Modified sequence Experiment N duplicates Sequence Length Missed cleavages Proteins Leading proteins Gene names Protein names GG (K) Intensity Reporter intensity corrected 1 Reporter intensity corrected 2 Reporter intensity corrected 3 Ubiproteome Fullproteome TMT Channel Normal 1 TMT Channel Normal 2 TMT Channel Normal 3 TMT Channel Ratio 1 TMT Channel Ratio 2 TMT Channel Ratio 3 Curve signal Log EC50 Curve slope Curve top Curve bottom R2 Curve RMSE Log EC50 error Curve slope error Curve top error Curve bottom error EC50 pEC50 Curve effect size Regulation (ac)AAAAKPNNLSLVVHGPGDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAAAKPNNLSLVVHGPGDLR 20 1 Q00796;A0A6I8PIS1;H0YKB3;Q00796-2;A0A6I8PRA7 Q00796 SORD Sorbitol dehydrogenase 0 21814600.0 6531500.0 9746800.0 5536300.0 False True 8562859.751135983 8292615.432728824 4963456.783939562 1.0 0.968439945735266 0.5796494311705958 23.029661265455747 -6.92301960215138 0.8020220182858907 1.0076812997591007 0.5123838016067339 0.9949791942103926 0.013544515774910103 0.09642772356099531 0.09664828976268526 0.0118605880933965 0.03662139545668887 1.1939342142852366e-07 6.92301960215138 -0.4952974981523668 (ac)AAAAKPNNLSLVVHGPGDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAAAKPNNLSLVVHGPGDLR 20 1 Q00796;A0A6I8PIS1;H0YKB3;Q00796-2;A0A6I8PRA7 Q00796 SORD Sorbitol dehydrogenase 0 17755200.0 4658600.0 3629900.0 9466700.0 False True 4510715.292988716 5079337.999678431 6987087.275087566 1.0 1.1260604293898933 1.54899762482195 22.10492479833074 -6.948913763700171 0.5706540260856013 0.9947469274490268 1.7008967734476386 0.999113187567959 0.006992102129923082 0.08392506963691175 0.0377917871527449 0.007402193818545178 0.03524457210021712 1.1248283049210713e-07 6.948913763700171 0.7061498459986117 (ac)AAAAKPNNLSLVVHGPGDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAAAKPNNLSLVVHGPGDLR 20 1 Q00796;A0A6I8PIS1;H0YKB3;Q00796-2;A0A6I8PRA7 Q00796 SORD Sorbitol dehydrogenase 0 50735000.0 14961000.0 21115000.0 14659000.0 False True 22696930.795608103 17346863.277752023 11761642.224732056 1.0 0.7642823355265582 0.5182040836555731 24.435993885722155 -6.970583689868099 0.24384759589294025 1.0842491051395289 0.19108577597120352 0.9999865818128398 0.0007205331055184129 0.07611378972069609 0.008349852144177763 0.0057254216665925005 0.023828971450098817 1.070080155339795e-07 6.970583689868099 -0.8931633291683254 (ac)AAAAKPNNLSLVVHGPGDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAAAKPNNLSLVVHGPGDLR 20 1 Q00796;A0A6I8PIS1;H0YKB3;Q00796-2;A0A6I8PRA7 Q00796 SORD Sorbitol dehydrogenase 0 23034000.0 6531500.0 5352500.0 11150000.0 False True 8946372.0571507 5116008.851649463 8516599.641458213 1.0 0.5718529051740381 0.9519612628507915 23.09287132697864 -10.272355593070962 8.073854151838523 1.0000003175789132 0.7619070840124148 0.3434609717606131 0.15517858721256117 8.869715831161352e-07 8.014116217814247e-08 0.1502512202489062 0.0500836736635204 5.341268461630947e-11 10.272355593070962 -0.23809323356649836 (ac)AAAAKPNNLSLVVHGPGDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAAAKPNNLSLVVHGPGDLR 20 1 Q00796;A0A6I8PIS1;H0YKB3;Q00796-2;A0A6I8PRA7 Q00796 SORD Sorbitol dehydrogenase 0 33687000.0 14961000.0 10844000.0 7882000.0 False True 19367309.425399523 10240521.867357895 6447556.876149611 1.0 0.5287529435517678 0.332909271728466 24.207120207814604 -13.999999999930573 0.1204668109250935 3.2452838699756508 0.022288046108317673 0.9996906543927774 0.004924135834270808 11.962006093512391 0.10687834062839456 6.426110978780424 0.2756508635289728 1.0000000001598619e-14 13.999999999930573 -3.222995823867333 (ac)AAAMDVDTPSGTNSGAGK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAAMDVDTPSGTNSGAGKK 19 1 P62877 P62877 RBX1 E3 ubiquitin-protein ligase RBX1;E3 ubiquitin-protein ligase RBX1, N-terminally processed 1 14579400.0 3780400.0 4988100.0 5810900.0 True False 4956141.009445674 4243894.923461516 5209643.810088755 1.0 0.8562901893576633 1.051149230855204 22.240785804166283 -6.709112294701548 1.798064939367518 0.911567531398683 1.0506839485880148 0.4608652897772294 0.06056765024790493 0.37694574172228085 2.374988149837573 0.02680971549398148 0.06819045987024683 1.9538341912496733e-07 6.709112294701548 0.13911641718933188 (ac)AAAMDVDTPSGTNSGAGK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 2 AAAMDVDTPSGTNSGAGKK 19 1 P62877 P62877 RBX1 E3 ubiquitin-protein ligase RBX1;E3 ubiquitin-protein ligase RBX1, N-terminally processed 1 32200500.0 8268600.0 6564500.0 17367400.0 True False 8006117.819002809 9185739.083415274 12818356.929168101 1.0 1.1473399831329725 1.6010702339082832 22.932671416081398 -6.950861276746826 0.5493061082428069 0.9936990864496199 1.776001388020307 0.9992671553817505 0.006924567481925989 0.08314171830094647 0.03454514992489421 0.007522478756631372 0.037635868013927126 1.1197955137753685e-07 6.950861276746826 0.782302301570687 (ac)AAAMDVDTPSGTNSGAGK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAAMDVDTPSGTNSGAGKK 19 1 P62877 P62877 RBX1 E3 ubiquitin-protein ligase RBX1;E3 ubiquitin-protein ligase RBX1, N-terminally processed 1 47632600.0 6696600.0 19606000.0 21330000.0 True False 10159231.787037566 16107156.117622841 17114116.15072889 1.0 1.585469891352847 1.6845876252735217 23.27628797784392 -11.485354309974872 0.3067507637500912 7.65296651400698e-11 1.7104983779884368 0.9993890121973567 0.007466809962913079 3.873293346187332 0.16261334814027123 2.6033156519469887 0.034741407029665314 3.2707374979635407e-12 11.485354309974872 1.7104983779119072 (ac)AAAMDVDTPSGTNSGAGK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AAAMDVDTPSGTNSGAGKK 19 1 P62877 P62877 RBX1 E3 ubiquitin-protein ligase RBX1;E3 ubiquitin-protein ligase RBX1, N-terminally processed 1 25563500.0 8268600.0 10414400.0 6880500.0 True False 6875707.261088828 10358295.56010345 8319180.738162445 1.0 1.5065061915482312 1.2099381812315597 22.713076691515674 -10.249105755564651 4.975237434959487 0.9999341967689892 1.3582221863901063 0.6604804027857349 0.12107338321899519 8.83931708674309e-05 1.3341024445028797e-05 0.11725026685197153 0.03907626640621131 5.6350042046138574e-11 10.249105755564651 0.3582879896211171 (ac)AAAMDVDTPSGTNSGAGK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AAAMDVDTPSGTNSGAGKK 19 1 P62877 P62877 RBX1 E3 ubiquitin-protein ligase RBX1;E3 ubiquitin-protein ligase RBX1, N-terminally processed 1 42608000.0 9058700.0 16953000.0 16596300.0 True False 11726665.723672645 16009550.647115309 13575943.692418398 1.0 1.3652261456380388 1.1576985319034558 23.48328953028665 -10.171428922233048 4.4229003692632025 0.9999434124932497 1.2614623387785935 0.6791206829652514 0.0847227935577597 4.7285149982633625e-05 8.858334486603077e-06 0.08205021813174747 0.027344164037395802 6.738621724858814e-11 10.171428922233048 0.2615189262853438 (ac)AAGTLYTYPENWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAGTLYTYPENWR 13 0 P26641 P26641 EEF1G Elongation factor 1-gamma 0 38632900.0 6498900.0 14555000.0 17579000.0 False True 8520120.835437123 12383450.734945623 15760093.709674988 1.0 1.4534360455828317 1.849750022807795 23.022442460743562 -6.972704642767267 0.18235528895448125 0.7030274602034451 2.6109009546194417 0.9999965164700836 0.0006479402051564429 0.07543444705465262 0.005766218738559557 0.014948111264290607 0.044161228632871155 1.0648669722476944e-07 6.972704642767267 1.9078734944159965 (ac)AAGTLYTYPENWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAGTLYTYPENWR 13 0 P26641 P26641 EEF1G Elongation factor 1-gamma 0 29726700.0 7812500.0 3463200.0 18451000.0 False True 7564496.463846301 4846073.820349417 13618129.581864903 1.0 0.6406340254781936 1.8002691450714918 22.850812620928167 -6.823480888691551 1.3568478270808049 0.8069592401020269 1.8275042132211992 0.8921820422104922 0.15915141301400385 0.18899706809192976 0.6827481255679954 0.09215249993584351 0.2122146446005264 1.5014784774822995e-07 6.823480888691551 1.0205449731191722 (ac)AAGTLYTYPENWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAGTLYTYPENWR 13 0 P26641 P26641 EEF1G Elongation factor 1-gamma 0 32539900.0 6498900.0 12754000.0 13287000.0 False True 8901718.956168814 12190486.10816203 10148884.254354741 1.0 1.3694530425176061 1.1401038725584178 23.085652522266454 -10.150179549192414 4.083357456155857 0.9999281791031537 1.2547784573091514 0.6219844107543024 0.09363140710107119 21833120.095281854 2.9815837545936668 17716.04219858877 0.03205252101531941 7.07653160767727e-11 10.150179549192414 0.2548502782059977 (ac)AAGTLYTYPENWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAGTLYTYPENWR 13 0 P26641 P26641 EEF1G Elongation factor 1-gamma 0 13955600.0 7812500.0 4172900.0 1970200.0 False True 6496439.902432882 4150419.7594441976 2382159.710824451 1.0 0.6388760339166514 0.36668694648161754 22.631217896362443 -7.791332092089274 0.20227666473227982 1.2239639638758637 1.1891736690139291e-11 0.9998868147066549 0.00275968540166488 0.12607410051816106 0.02848469829607693 0.05622270170608973 0.08928510189145013 1.6168432128463976e-08 7.791332092089274 -1.2239639638639719 down (ac)AAGTLYTYPENWRAFKALIAAQYSGAQVRVLSAPPHFHFGQTNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAGTLYTYPENWRAFKALIAAQYSGAQVRVLSAPPHFHFGQTNR 44 3 P26641 P26641 EEF1G Elongation factor 1-gamma 0 63758000.0 20819000.0 21319000.0 21620000.0 False True 31583945.07277356 17514457.883892722 17346797.523617357 1.0 0.5545367383186968 0.5492283336881462 24.91268805014856 (ac)AAGTLYTYPENWRAFKALIAAQYSGAQVRVLSAPPHFHFGQTNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAGTLYTYPENWRAFKALIAAQYSGAQVRVLSAPPHFHFGQTNR 44 3 P26641 P26641 EEF1G Elongation factor 1-gamma 0 46698000.0 20819000.0 10778000.0 15101000.0 False True 26950605.903842848 10178194.825376568 12352772.949344737 1.0 0.37766107603262733 0.4583486172228645 24.68381437224101 -10.636992028478423 6.605229809114856 1.0023289935911905 0.41800484662866283 0.9857891667165468 0.03294055075264686 0.0011328633843479805 6.225948386113111e-05 0.03198196327613312 0.010631517039991784 2.306789529699555e-11 10.636992028478423 -0.5843241469625278 (ac)AAGVEAAAEVAATEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAGVEAAAEVAATEIK 16 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 6545250.0 855450.0 3729800.0 1960000.0 False True 1121503.2341895844 3173328.37864653 1757198.0016475879 1.0 2.8295311880572744 1.5668238379333488 20.097002350196462 -10.48357507745821 5.064523424758678 0.997095475481875 2.1981775129953487 0.5455655256071644 0.5154981170443766 0.016927427031691363 0.0017260736453733405 0.4997596998289209 0.16637630185949412 3.28416465306725e-11 10.48357507745821 1.2010820375134736 (ac)AAGVEAAAEVAATEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAGVEAAAEVAATEIK 16 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 13028300.0 4241500.0 1688800.0 7098000.0 False True 4106855.904179721 2363146.646975658 5238820.864564363 1.0 0.5754150381976109 1.2756281171765955 21.969602898191592 -6.742573299331288 1.677376289281496 0.7481252391376685 1.27626404603897 0.6163731389452163 0.17838579050548567 0.31319168019436994 1.7311991222974197 0.08410061074173597 0.20578718998287787 1.808950573522474e-07 6.742573299331288 0.5281388069013015 (ac)AAGVEAAAEVAATEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAGVEAAAEVAATEIK 16 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 7210850.0 855450.0 1697700.0 4657700.0 False True 1171732.9826670075 1622690.0004568512 3557647.188342598 1.0 1.3848632960415694 3.0362268886934958 20.160212411719353 -6.9432655296042105 0.6284486100452205 0.9819853670938281 3.527868125193365 0.9985611120899699 0.033504432498221534 0.086307936564809 0.048058928253156205 0.033486095780385326 0.140213845580096 1.1395528467784263e-07 6.9432655296042105 2.5458827580995367 up (ac)AAIGVHLGCTSACVAVYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAIGVHLGCTSACVAVYK 18 0 Q0VDF9;B0YIZ1 Q0VDF9 HSPA14 Heat shock 70 kDa protein 14 0 42216000.0 14971000.0 13699000.0 13546000.0 False True 22712101.52670602 11254306.419224482 10868627.162577283 1.0 0.49552025848383546 0.47853903566772144 24.436957867477176 (ac)AAIGVHLGCTSACVAVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAIGVHLGCTSACVAVYK 18 0 Q0VDF9;B0YIZ1 Q0VDF9 HSPA14 Heat shock 70 kDa protein 14 0 33318600.0 14971000.0 7795600.0 10552000.0 False True 19380254.622528985 7361768.007116856 8631644.272663115 1.0 0.37985919950499586 0.44538342972176836 24.208084189569625 -10.19503140704252 5.388136209552423 1.0000270170396175 0.41262131461790996 0.9907531410989213 0.026750154970315018 8.682072671456037e-06 1.297119179898655e-06 0.025901914271967807 0.008633575392323165 6.382173303113769e-11 10.19503140704252 -0.5874057024217075 (ac)AANATTNPSQLLPLELVDK(ub)CIGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AANATTNPSQLLPLELVDKCIGSR 24 1 B8ZZF8;Q9Y4Y9 B8ZZF8 LSM5 U6 snRNA-associated Sm-like protein LSm5 1 28547500.0 8936100.0 9820600.0 9790800.0 True False 13556717.016418245 8068037.201301986 7855644.088539912 1.0 0.595132080394609 0.5794650783833661 23.692504512480888 (ac)AANATTNPSQLLPLELVDK(ub)CIGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AANATTNPSQLLPLELVDKCIGSR 24 1 B8ZZF8;Q9Y4Y9 B8ZZF8 LSM5 U6 snRNA-associated Sm-like protein LSm5 1 25900100.0 8936100.0 8388500.0 8575500.0 True False 11567957.606865352 7921672.600915875 7014846.992060503 1.0 0.6847944010630296 0.6064032416489261 23.463630834573337 -13.999999999999998 0.1954212699078681 2.7225472671242588 0.5531324433758853 0.9994873291579183 0.0038515291805648164 12.444041380876863 0.14018515993120867 8.17824297105531 0.0516747292367619 1.0000000000000041e-14 13.999999999999998 -2.1694148237483732 (ac)AAPSAGSWSTFQHK(ub)ELMAADR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAPSAGSWSTFQHKELMAADR 21 1 P42575;A0A087WYM1;C9JRR9 P42575 CASP2 Caspase-2;Caspase-2 subunit p18;Caspase-2 subunit p13;Caspase-2 subunit p12 1 19682400.0 6441300.0 8341100.0 4900000.0 True False 5356226.347973229 8296164.838721273 5924567.344959803 1.0 1.548882422017229 1.106108472656618 22.352785497909952 -13.20577387290062 10.715989787655701 1.0814796660216084 1.294745726041769 0.0 0.2496961597795119 0.0 0.0 0.0 0.0683524765848503 6.226243869139607e-14 13.20577387290062 0.21326606002016057 (ac)AAPSAGSWSTFQHK(ub)ELMAADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAPSAGSWSTFQHKELMAADR 21 1 P42575;A0A087WYM1;C9JRR9 P42575 CASP2 Caspase-2;Caspase-2 subunit p18;Caspase-2 subunit p13;Caspase-2 subunit p12 1 29226900.0 6570200.0 4150700.0 18506000.0 True False 8505253.418004125 3919709.89624146 15138097.88759511 1.0 0.46085750813069526 1.7798526561889878 23.019922791626836 -6.795731990154492 1.4732874726749232 0.7008939991050486 1.7961921687624605 0.8193571567175348 0.23013110760452113 0.22692564190397574 0.9728169777020795 0.12291004868812982 0.2866169127957152 1.600545445271069e-07 6.795731990154492 1.0952981696574118 (ac)AAPVDLELK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAPVDLELKK 10 1 O60925;E5RGS4;D6RGG5 O60925 PFDN1 Prefoldin subunit 1 1 29850100.0 12945000.0 11249000.0 5656100.0 True False 19638511.406266093 9241528.061161844 4538169.355843308 1.0 0.4705819025678868 0.23108520100944652 24.22718224212336 -10.113432532487467 0.18885680548085343 1.6793998891597834 1.8571398328563652e-24 0.9994886076056142 0.007264968136055539 1.6741410570150939 0.08889031514187119 0.7212928434980027 0.15374744036160629 7.701360754638221e-11 10.113432532487467 -1.6793998891597834 (ac)AAQGEPQVQFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAQGEPQVQFK 11 0 B5MDF5;P62826;A0A087X0W0 B5MDF5 RAN GTP-binding nuclear protein Ran 0 10346600.0 2729900.0 1375100.0 6241600.0 False True 2643240.818771708 1924184.6010517657 4606737.716013659 1.0 0.7279641670886114 1.7428369308228115 21.333876440471112 -6.835357257416285 1.3036863769134102 0.8550859796764012 1.773282768318788 0.9161898951600113 0.12417319336216744 0.17429109719089786 0.5773968850108213 0.07473702099661629 0.17203298285450128 1.4609748592908458e-07 6.835357257416285 0.9181967886423867 (ac)AAQIPESDQIK(ub)QFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAQIPESDQIKQFK 14 1 Q9Y5J7;G3V2F3;A0A1W2PRH9;A0A1W2PQS5;G3V502 Q9Y5J7 TIMM9 Mitochondrial import inner membrane translocase subunit Tim9 1 4989000.0 1625500.0 1489100.0 1874400.0 True False 2226491.277485793 1423306.6382048035 1431705.3244797557 1.0 0.6392599210233759 0.6430320832410678 21.086340529206208 -9.995201526763772 4.981724957182785 1.000003467753015 0.6411460021277596 0.9999171339702605 0.0015399787941652971 422178.1220986061 847047.094458669 10.212079102615592 0.0005271756428955006 1.0111101573873598e-10 9.995201526763772 -0.35885746562525533 (ac)AAQIPESDQIK(ub)QFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAQIPESDQIKQFK 14 1 Q9Y5J7;G3V2F3;A0A1W2PRH9;A0A1W2PQS5;G3V502 Q9Y5J7 TIMM9 Mitochondrial import inner membrane translocase subunit Tim9 1 14439700.0 2516300.0 3406600.0 8516800.0 True False 3257399.9536884464 3217019.715357932 6966829.789747647 1.0 0.9876035368991791 2.138770150671522 21.635289438513883 -6.904467569810994 0.9326057624138374 0.9578267799718273 2.2711875322382764 0.988660520975772 0.057478162504283774 0.10819069639430988 0.15945974830633444 0.04580707890736202 0.1220867212173387 1.246041279773436e-07 6.904467569810994 1.313360752266449 up (ac)AAQIPESDQIKQFK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAQIPESDQIKQFK 14 1 Q9Y5J7;G3V2F3;A0A1W2PRH9;A0A1W2PQS5;G3V502 Q9Y5J7 TIMM9 Mitochondrial import inner membrane translocase subunit Tim9 1 5307900.0 1850200.0 1666400.0 1791300.0 True False 1791466.4137482755 2331802.2101612 1322104.7921518942 1.0 1.3016164814847868 0.7380014394942864 20.77270956560907 -6.761320358833736 1.607327278779248 1.1749069240987782 0.7357941405485455 0.6963995094942925 0.12688653393064236 0.28070515944056335 1.4295648178159683 0.06227526146639488 0.14947312332723037 1.7325255228039966e-07 6.761320358833736 -0.43911278355023264 (ac)AASCVLLHTGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AASCVLLHTGQK 12 0 P14550;Q5T621;V9GYG2;V9GYP9 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 36402300.0 8542300.0 10148000.0 17712000.0 False True 11199038.023750873 8633957.956594188 15879332.145501072 1.0 0.770955321187706 1.4179192991241079 23.416871477032924 -6.811019386181867 1.4103490944779913 0.8753241506655177 1.4294923925601444 0.8624505018459516 0.09933837455559041 0.20541194989105732 0.805101582001276 0.05538202772494141 0.12804555067364043 1.545185463495089e-07 6.811019386181867 0.5541682418946267 (ac)AASCVLLHTGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AASCVLLHTGQK 12 0 P14550;Q5T621;V9GYG2;V9GYP9 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 35759300.0 8542300.0 12070000.0 15147000.0 False True 11700619.15697747 11536707.489847554 11569590.562257191 1.0 0.9859911971383011 0.988801567424563 23.480081538555815 -9.90998551328721 6.645036598666082 1.0000000007199612 0.9873963822814344 0.9640492362230324 0.001147328864937927 1.1692805932960606e-11 2.491129653623596e-12 0.0011108964628460392 0.0003702987988771501 1.2303098094355617e-10 9.90998551328721 -0.012603618438526754 (ac)AATFFGEVVK(ub)APCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AATFFGEVVKAPCR 14 1 O95456;O95456-2;F8WBH7 O95456 PSMG1 Proteasome assembly chaperone 1 1 32994900.0 5608900.0 11934000.0 15452000.0 True False 7353322.21666487 10153493.718367664 13853175.266050264 1.0 1.380803590431105 1.8839342079495367 22.809964773371455 -6.967280078086577 0.3164850041197818 0.9281916026863551 2.352690946482491 0.9999527267212936 0.0024890455405512085 0.07719550281109816 0.012174813447691371 0.0077381330317839855 0.0443966036037774 1.0782511298944128e-07 6.967280078086577 1.424499343796136 (ac)AATFFGEVVK(ub)APCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AATFFGEVVKAPCR 14 1 O95456;O95456-2;F8WBH7 O95456 PSMG1 Proteasome assembly chaperone 1 1 46377000.0 11105000.0 16423000.0 18849000.0 True False 10752477.853569672 22980789.544813614 13911881.44212085 1.0 2.137255231563608 1.2938302809433178 23.358165824038334 -10.247178155880945 5.079706133688453 0.9998927240569582 1.7155427562537389 0.48970718739390584 0.3443267942264252 0.00041840594022501444 6.200791698115289e-05 0.3334424337845698 0.11113099497416665 5.6600705451725436e-11 10.247178155880945 0.7156500321967807 (ac)AATFFGEVVK(ub)APCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AATFFGEVVKAPCR 14 1 O95456;O95456-2;F8WBH7 O95456 PSMG1 Proteasome assembly chaperone 1 1 131970000.0 13888000.0 48270000.0 69812000.0 True False 21069111.348800573 39655841.36476864 56013627.60031347 1.0 1.8821791155907568 2.658566214445595 24.328626129780364 -6.972627852878683 0.18494215121853158 0.43772898328233895 4.124115975728223 0.9999962866264862 0.0013056643714473505 0.07545887824185978 0.0058653601141655 0.02862973788247971 0.08585763621173866 1.0650552736173196e-07 6.972627852878683 3.6863869924458843 (ac)AATFFGEVVK(ub)APCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AATFFGEVVKAPCR 14 1 O95456;O95456-2;F8WBH7 O95456 PSMG1 Proteasome assembly chaperone 1 1 39305400.0 5608900.0 9857500.0 23839000.0 True False 7682661.904823172 9421963.055606654 18208719.17961639 1.0 1.2263930356861792 2.3701054927570047 22.873174834894346 -6.93957623233985 0.66350481942313 0.9870638475754498 2.6747103342058063 0.9981077326004484 0.0260861031029728 0.08796069660117903 0.05549630193119023 0.02531190647484601 0.09862239671608403 1.1492744918962284e-07 6.93957623233985 1.6876464866303564 up (ac)AATFFGEVVK(ub)APCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AATFFGEVVKAPCR 14 1 O95456;O95456-2;F8WBH7 O95456 PSMG1 Proteasome assembly chaperone 1 1 52318000.0 11105000.0 11589000.0 29624000.0 True False 9234299.534914184 11526567.756763618 35818241.43409988 1.0 1.2482341203231 3.8788260331683886 23.13857109947261 -6.9252670449190425 0.7846712564225361 0.9522140166629562 4.359070936393207 0.9955234180572784 0.08714875719305548 0.09517081577705605 0.09027375569280169 0.07726495240522427 0.24450899467579684 1.1877716496015118e-07 6.9252670449190425 3.4068569197302514 up (ac)AATFFGEVVK(ub)APCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AATFFGEVVKAPCR 14 1 O95456;O95456-2;F8WBH7 O95456 PSMG1 Proteasome assembly chaperone 1 1 118077000.0 13888000.0 58511000.0 45678000.0 True False 17978289.773407433 55254811.41469734 37365072.6958591 1.0 3.0734186683556204 2.078344112081651 24.099752451872813 -10.473694795615222 6.0995020123689105 0.9990287666117045 2.5758813902186306 0.7698007996095542 0.4062374864829356 0.005367675483473268 0.0004631585692031014 0.3935064211954428 0.13111258497946401 3.359736398202418e-11 10.473694795615222 1.5768526236069262 (ac)AAVDLEK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAVDLEKLR 9 1 P17858;F8WEU2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 1 16059200.0 4266000.0 3322000.0 8471200.0 True False 5522421.095431747 3137127.779727305 6929528.521852144 1.0 0.5680710915584466 1.2547990097286104 22.396869469768905 -6.7366930443943245 1.6988918677217366 0.7420252338033516 1.2549124036899835 0.5899879377202655 0.18149737239900252 0.3238223736351006 1.83383724830565 0.08456249849641419 0.20825977243015487 1.8336099442283326e-07 6.7366930443943245 0.5128871698866319 (ac)AAVK(ub)ASTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAVKASTSK 9 1 H7BYE2;Q9NWZ8 H7BYE2 GEMIN8 Gem-associated protein 8 1 8982300.0 2402100.0 3773600.0 2806600.0 True False 3149176.361969488 3210593.5893775895 2516199.9548082263 1.0 1.0195026319102978 0.7990025535548604 21.586543123689875 -6.885333606288482 1.0495606754975664 1.0132066130076407 0.7816824241774076 0.9777408210687768 0.014869745183670893 0.12301236437040187 0.24460232170425683 0.010855423678126754 0.026646626756518535 1.3021661263209694e-07 6.885333606288482 -0.23152418883023307 (ac)AAVK(ub)ASTSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAVKASTSK 9 1 H7BYE2;Q9NWZ8 H7BYE2 GEMIN8 Gem-associated protein 8 1 10864900.0 3137000.0 4051300.0 3676600.0 True False 3037417.652106983 5669005.2172504 2713588.164364238 1.0 1.8663897647786265 0.8933865787215293 21.534413865447593 -6.671837445054967 1.9306482871033432 1.55214269660555 0.8972728755861624 0.287218177623075 0.3678698006351952 0.45696511327124334 3.285461207194689 0.15329336986152411 0.4086141489821157 2.1289357502700817e-07 6.671837445054967 -0.6548698210193876 (ac)AAVK(ub)ASTSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAVKASTSK 9 1 H7BYE2;Q9NWZ8 H7BYE2 GEMIN8 Gem-associated protein 8 1 9005700.0 2397100.0 1834200.0 4774400.0 True False 3636575.951483998 1506872.6793299883 3830737.7473061457 1.0 0.4143657933818405 1.053391376507045 21.794149277257354 -6.665712589984662 1.9529299160938178 0.6248102501275559 1.0507440620613926 0.2600109056823767 0.24901559004660168 0.47105991766766836 3.459502898430495 0.10281267881175328 0.27619868971613126 2.1591728468385855e-07 6.665712589984662 0.4259338119338367 (ac)AAVK(ub)ASTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAVKASTSK 9 1 H7BYE2;Q9NWZ8 H7BYE2 GEMIN8 Gem-associated protein 8 1 8800100.0 2402100.0 3424300.0 2973700.0 True False 3290221.284311668 3273003.1033541798 2271373.3052739315 1.0 0.9947668623263768 0.6903405907998419 21.649753185212766 -6.910630754272546 0.8914304069806991 1.0092386331578374 0.6504634214236285 0.9911573884896372 0.013612260623153674 0.10400232385326136 0.13651642447453952 0.011179415013005768 0.03099670926951873 1.2284832679501624e-07 6.910630754272546 -0.3587752117342089 (ac)AAVK(ub)ASTSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAVKASTSK 9 1 H7BYE2;Q9NWZ8 H7BYE2 GEMIN8 Gem-associated protein 8 1 9475500.0 3137000.0 4596400.0 1742100.0 True False 2608554.4926632857 4571638.280886036 2106365.0554396887 1.0 1.7525561738288544 0.8074836317830298 21.31481914088187 -6.694568875143003 1.8502221355398634 1.469765764923426 0.810558855988349 0.3919078194251764 0.3179884260150392 0.40690125450872233 2.7041092896796224 0.13731316909691782 0.35552208740659175 2.020370994174717e-07 6.694568875143003 -0.6592069089350769 (ac)AAVK(ub)ASTSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAVKASTSK 9 1 H7BYE2;Q9NWZ8 H7BYE2 GEMIN8 Gem-associated protein 8 1 6716700.0 2397100.0 1803500.0 2516100.0 True False 3103093.2039051615 1703133.6395960865 2058195.6173661514 1.0 0.5488503011938982 0.6632722519503979 21.565275599349803 -10.063065362284659 7.369088066596382 1.0000000490992447 0.6060612765721589 0.9404916945398735 0.04671256578788138 3.770662737401632e-08 4.755861380308431e-09 0.04522925340445407 0.015076415779590228 8.648377489773669e-11 10.063065362284659 -0.39393877252708576 (ac)AAVK(ub)DSCGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAVKDSCGK 9 1 P61758 P61758 VBP1 Prefoldin subunit 3 1 2349420.0 830540.0 1040000.0 478880.0 True False 1137613.0824995686 994049.3611799051 365778.40684318496 1.0 0.8738026807812155 0.321531470119432 20.117578530417983 -6.9428151729024075 0.6328322698904183 1.0060263534983225 0.15939857578990446 0.9985098665488116 0.011373285806590886 0.08650550607228998 0.04893519557545162 0.011323260654217206 0.046975203113666195 1.140735158477025e-07 6.9428151729024075 -0.846627777708418 down (ac)AAVK(ub)DSCGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAVKDSCGK 9 1 P61758 P61758 VBP1 Prefoldin subunit 3 1 3172790.0 1419800.0 1308200.0 444790.0 True False 1180626.6078046984 1301152.4669426316 537793.5325234025 1.0 1.1020863483350114 0.4555153415722148 20.171121330634726 -6.866511409425099 1.1523164046177627 1.0566867104698319 0.4200654748795559 0.9610797007165982 0.05599092347615997 0.1402477395141373 0.35023371107442636 0.03778247852808439 0.08895320351891232 1.3598424381604572e-07 6.866511409425099 -0.636621235590276 down (ac)AAVK(ub)TLNPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAVKTLNPK 9 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 4471020.0 900320.0 2243000.0 1327700.0 True False 1180328.2387112814 1908353.14314552 1190322.3401977054 1.0 1.616798684092417 1.0084672222172164 20.17075668527579 -10.31365137722241 4.023018515885653 0.9994587396019942 1.3126329531731007 0.2604370784852773 0.24835027940905888 176530147.6989227 758.6473419517802 885987.0677727904 0.08501690636252744 4.856782139493659e-11 10.31365137722241 0.31317421357110653 (ac)AAVK(ub)TLNPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAVKTLNPK 9 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 10691200.0 2778500.0 3098500.0 4814200.0 True False 2690298.038374008 4335747.208464043 3553216.5970957666 1.0 1.6116233765254238 1.3207520305978064 21.35933457655448 -10.003165407850403 4.3710271825165865 0.9999803868618771 1.466187703562352 0.7740104551798335 0.11874773005482923 11911474.284217892 4543266.8817658955 2241.9078286572912 0.04065050632787345 9.927378766519177e-11 10.003165407850403 0.466207316700475 (ac)AAVK(ub)TLNPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAVKTLNPK 9 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 3770420.0 900320.0 1725700.0 1144400.0 True False 1233192.6342331627 1649452.8678732319 874116.2896578294 1.0 1.337546805004161 0.7088238004286994 20.233966746798682 -6.760880958492573 1.6092293209317718 1.1958514327812326 0.7064319927707934 0.6945306637775439 0.14199103049856276 0.28143710240611985 1.4366323242130403 0.06961294369357547 0.16714063201310794 1.7342793041173967e-07 6.760880958492573 -0.48941944001043924 (ac)AAVK(ub)TLNPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAVKTLNPK 9 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 10583800.0 2778500.0 5652700.0 2152600.0 True False 2310445.858420449 5622247.7831269 2602698.707502135 1.0 2.433403822312714 1.1264919703773049 21.139739851988757 -6.624164333354951 2.1017658713289973 1.9483203535278708 1.1316160917017044 0.09690980559789908 0.6157629055817138 0.574293262609808 4.826454937283916 0.24027080836222256 0.682388573185262 2.3759410805209096e-07 6.624164333354951 -0.8167042618261664 (ac)AAVK(ub)TLNPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAVKTLNPK 9 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 9808800.0 2772600.0 2325000.0 4711200.0 True False 3589185.3561167517 2195611.7061607437 3853809.9409941677 1.0 0.6117298184165787 1.0737283139825693 21.775224999428662 -6.683839422497594 1.8880945967654712 0.7551834306446898 1.0720299148425576 0.3417399204379161 0.16442293926424845 0.43011310708207157 2.967668419910641 0.06979063261095345 0.18317788023645223 2.0709069113379852e-07 6.683839422497594 0.31684648419786776 (ac)AAVQMDPELAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAVQMDPELAKR 12 1 A2A2Q9;Q9Y312 A2A2Q9 AAR2 Protein AAR2 homolog 1 5483200.0 2364300.0 2008100.0 1110800.0 True False 1966020.206249223 1997281.966723358 1343063.144241091 1.0 1.0159010372196409 0.6831380165737917 20.90684671872685 -6.8956778808592745 0.9881676211038121 1.0155229794601426 0.6511169389172823 0.9842911904680255 0.019208261057074346 0.1146577973764137 0.1958948560791355 0.01468885933322133 0.0374538028157574 1.271516848151549e-07 6.8956778808592745 -0.3644060405428603 (ac)AAYK(ub)LVLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAYKLVLIR 9 1 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 1 1207290000.0 280700000.0 594750000.0 331840000.0 True False 368000418.30266666 506015618.31734186 297504380.03404856 1.0 1.3750408780817276 0.8084348963684119 28.455132165280208 -6.72823483844235 1.7297094809211324 1.2261437307112966 0.8088830437466868 0.5510155242423296 0.15768171242273787 0.3395716765557304 1.9895508722701398 0.07226616007911575 0.17968008499805793 1.8696708695692671e-07 6.72823483844235 -0.4172606869646097 (ac)AAYK(ub)LVLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAYKLVLIR 9 1 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 1 2728250000.0 666760000.0 953790000.0 1107700000.0 True False 645594068.7659713 1334643320.9491417 817560139.7123067 1.0 2.0673103820489893 1.266368728069392 29.26605208337564 -10.143494574004087 4.488419604494111 0.9999281662150311 1.6668395545003551 0.4803113860181797 0.32698306134725974 230395693.32109746 134864991.08811143 244742.16136911724 0.11966354522624405 7.186301367580077e-11 10.143494574004087 0.666911388285324 (ac)AAYK(ub)LVLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAYKLVLIR 9 1 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 1 1939070000.0 657440000.0 465080000.0 816550000.0 True False 997384545.3020914 382082840.31337446 655158534.5934209 1.0 0.38308478120407197 0.6568765654925846 29.893574607390903 -10.41836422652424 6.05232504470003 1.0001448805095334 0.5199806733483624 0.8038604031084816 0.11177502787883646 0.00021857881080720917 2.100559168629364e-05 0.10825792501251512 0.036075235124716866 3.8162408276174986e-11 10.41836422652424 -0.48016420716117103 (ac)AAYK(ub)LVLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAYKLVLIR 9 1 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 1 1241900000.0 280700000.0 448270000.0 512930000.0 True False 384482375.63227403 428463949.1693428 391786498.1249479 1.0 1.1143916505008635 1.0189972881869094 28.5183422268031 -10.260284025647609 4.679513748608617 0.999976954941996 1.0666944693440952 0.3945770553998216 0.03894458533528344 9.366530617315689e-06 1.4805850406497831e-06 0.037720959629466234 0.012569310868940139 5.4918159534645416e-11 10.260284025647609 0.06671751440209917 (ac)AAYK(ub)LVLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAYKLVLIR 9 1 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 1 2084300000.0 666760000.0 906210000.0 511330000.0 True False 554440482.4763061 901328066.8613979 618246738.8772032 1.0 1.6256534206084348 1.1150822467290236 29.046457358809917 -10.103215147935051 4.33478558829732 0.9999562894134041 1.370367833383804 0.41231954490758793 0.20843980902663267 30774731.495261353 35863803.15657475 11189.838337524932 0.07135449673847476 7.884694159181685e-11 10.103215147935051 0.3704115439704 (ac)AAYK(ub)LVLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAYKLVLIR 9 1 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 1 1407750000.0 657440000.0 419800000.0 330510000.0 True False 851069040.0798517 396437760.9661422 270360571.318981 1.0 0.46581151739340243 0.3176717264836873 29.664700929483352 -13.999999999999998 0.17995037390830923 3.7712384076207277 0.19993629108307204 0.9994981979345259 0.006564464719760856 12.204054583562534 0.134475287129814 11.82490529477927 0.11065280359306039 1.0000000000000041e-14 13.999999999999998 -3.5713021165376557 (ac)ACGLVASNLNLKPGECLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ACGLVASNLNLKPGECLR 18 1 P09382;F8WEI7 P09382 LGALS1 Galectin-1 0 100580000.0 15731000.0 57088000.0 27761000.0 False True 20623493.339220695 48570692.9272811 24888558.02231565 1.0 2.355114729031471 1.206806122170577 24.297785390530894 -6.605669771825626 2.169364518962441 1.9079645350935235 1.2107298597474057 0.03721126199559888 0.5848766497878497 0.6247434416309446 5.564754446689975 0.2231143122984943 0.6499500278105197 2.479306552404805e-07 6.605669771825626 -0.6972346753461178 (ac)ACGLVASNLNLKPGECLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ACGLVASNLNLKPGECLR 18 1 P09382;F8WEI7 P09382 LGALS1 Galectin-1 0 34632600.0 21091000.0 5211900.0 8329700.0 False True 20421477.7496297 7293038.849699452 6147901.684356419 1.0 0.3571259112152986 0.3010507740786731 24.283583931256057 -13.999999999999998 0.34537121275195165 8.683930645589745 0.2928221107677488 0.9997457917600059 0.005055781940464737 20.20768963197807 0.18886224623658718 113.66259383832427 0.017000106249925182 1.0000000000000041e-14 13.999999999999998 -8.391108534821997 (ac)ACGLVASNLNLKPGECLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ACGLVASNLNLKPGECLR 18 1 P09382;F8WEI7 P09382 LGALS1 Galectin-1 0 223082000.0 13819000.0 189330000.0 19933000.0 False True 20964433.304224856 155542582.25795814 15993233.813055754 1.0 7.419355438842816 0.7628746067671058 24.32144049700808 -6.654443130703641 1.992716409563194 5.150881904418121 0.7909086164103014 0.21218695119961428 2.736900045814085 0.497781545188792 3.7937164939526595 1.1119632078922808 3.0322649966775574 2.2159342459143657e-07 6.654443130703641 -4.3599732880078195 (ac)ACGLVASNLNLKPGECLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ACGLVASNLNLKPGECLR 18 1 P09382;F8WEI7 P09382 LGALS1 Galectin-1 0 73974000.0 15731000.0 29305000.0 28938000.0 False True 21547175.814290356 28010208.201324154 22103440.396817777 1.0 1.2999480044501903 1.0258161249215083 24.360995452053785 -10.488366877639333 3.033670675666754 0.9954364135254652 1.1628820645723816 0.32006266681215323 0.1119138731410407 837033288.4859713 896019526.143563 31531217.614220064 0.04095634174333907 3.24812790333491e-11 10.488366877639333 0.16744565104691644 (ac)ACGLVASNLNLKPGECLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ACGLVASNLNLKPGECLR 18 1 P09382;F8WEI7 P09382 LGALS1 Galectin-1 0 35902400.0 21091000.0 3204400.0 11607000.0 False True 17538100.98972309 3187137.261176399 14033970.035295598 1.0 0.18172647443665568 0.8001989521852548 24.063989206690334 -10.377470782721428 7.911342852792709 1.0000060493334122 0.4909627133241307 0.47457674960720675 0.25249033173981517 2.6940649974352656e-05 2.1200491176582566e-06 0.24447561292138226 0.08149090415889083 4.193042045393629e-11 10.377470782721428 -0.5090433360092814 (ac)ACGLVASNLNLKPGECLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ACGLVASNLNLKPGECLR 18 1 P09382;F8WEI7 P09382 LGALS1 Galectin-1 0 62745000.0 13819000.0 30604000.0 18322000.0 False True 17888967.913214073 28900860.496921897 14987583.99959568 1.0 1.6155689158329616 0.8378115535958213 24.09256681910053 -6.695717126303479 1.8457830583204895 1.3838218099329633 0.8402722332554662 0.39749102265668057 0.2600462411972121 0.40447314760584024 2.6758450648061856 0.11251799127586352 0.2909450175482265 2.015036297788058e-07 6.695717126303479 -0.5435495766774971 (ac)ACPLDQAIGLLVAIFHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ACPLDQAIGLLVAIFHK 17 0 R4GN98;P06703 R4GN98 S100A6 Protein S100;Protein S100-A6 0 11818926600.0 4602526600.0 4132600000.0 3083800000.0 False True 6982369341.965473 3395105241.848825 2474285578.322445 1.0 0.48623970969904806 0.35436188736844393 32.70106952622051 -13.999999999999995 0.19093624883409108 3.7630302129538205 0.26063753317094557 0.9994889200011067 0.006296653682958692 12.366102549657137 0.13857046802825584 12.716076359423225 0.09002336461956044 1.0000000000000123e-14 13.999999999999995 -3.502392679782875 (ac)ACPLDQAIGLLVAIFHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ACPLDQAIGLLVAIFHK 17 0 R4GN98;P06703 R4GN98 S100A6 Protein S100;Protein S100-A6 0 6587006600.0 4602526600.0 256380000.0 1728100000.0 False True 5958061413.062735 242112227.62386754 1413603531.803367 1.0 0.040636074528041834 0.23725897297804213 32.47219584831295 -10.124883178219845 7.053146353046131 1.0000005790320452 0.13894752375412903 0.9623634894357299 0.08027096215826272 7.309297400391714e-07 9.072232709312396e-08 0.07772207643638028 0.025907341635249753 7.500959520751295e-11 10.124883178219845 -0.8610530552779162 (ac)ACPLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ACPLEK 6 0 P26447 P26447 S100A4 Protein S100-A4 0 16871900.0 6622300.0 1727400.0 8522200.0 False True 6412078.711363751 2417159.828271996 6289980.159480204 1.0 0.3769697686318487 0.9809580391352403 22.612360704703903 -10.937682865621499 10.401580010191946 1.072170083268113 0.6789639038835446 0.27362251595399145 0.24657717889323486 0.1269838494234226 0.0007607747835921691 0.07346419843607008 0.07958244228402549 1.1542958503212538e-11 10.937682865621499 -0.39320617938456837 (ac)ADEIAK(ub)AQVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADEIAKAQVAR 11 1 P49773;D6REP8;D6RE99;D6RD60;D6RC06 P49773 HINT1 Histidine triad nucleotide-binding protein 1 1 8495500.0 3303500.0 2637100.0 2554900.0 True False 3198632.200744478 3690107.7822948224 1885695.0446429283 1.0 1.1536517957381764 0.5895316892651912 21.609023680981267 -6.834135298244977 1.309284857962541 1.081898856646384 0.5730242418931666 0.9138941416315146 0.06987444113218887 0.17577029820548729 0.5877977050104405 0.04188267684993343 0.09639347128693801 1.4650913415627913e-07 6.834135298244977 -0.5088746147532175 (ac)ADEIAK(ub)AQVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADEIAKAQVAR 11 1 P49773;D6REP8;D6RE99;D6RD60;D6RC06 P49773 HINT1 Histidine triad nucleotide-binding protein 1 1 15398300.0 4888000.0 4334900.0 6175400.0 True False 7415453.36066655 3561303.2262717076 4954829.483226029 1.0 0.4802542815739042 0.6681762047763262 22.822103467154612 -10.246782471491365 5.017388006230848 1.0000707954762544 0.574215243174848 0.8725278677626588 0.07671880388899739 6.076575596249943e-05 9.122370502135116e-06 0.07429496313684049 0.024760887483453876 5.665229768255127e-11 10.246782471491365 -0.4258555523014065 (ac)ADEIAK(ub)AQVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADEIAKAQVAR 11 1 P49773;D6REP8;D6RE99;D6RD60;D6RC06 P49773 HINT1 Histidine triad nucleotide-binding protein 1 1 10189400.0 3303500.0 4996300.0 1889600.0 True False 2747006.6198639376 4969383.9402121045 2284706.623476742 1.0 1.8090178248126114 0.8317077239478607 21.389428956415543 -6.686911800139486 1.8775294538749967 1.5086745142581104 0.8352214996492587 0.35591004777191415 0.34237701644297824 0.4233625979203191 2.8910643302635957 0.1460188433666926 0.38171032071292854 2.0563081644439585e-07 6.686911800139486 -0.6734530146088517 (ac)ADEIAK(ub)AQVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADEIAKAQVAR 11 1 P49773;D6REP8;D6RE99;D6RD60;D6RC06 P49773 HINT1 Histidine triad nucleotide-binding protein 1 1 15933100.0 4888000.0 4712000.0 6333100.0 True False 6327612.35688475 4449773.057819105 5180540.783093509 1.0 0.7032309830069687 0.8187196830186396 22.59322978924706 -10.09190749348463 6.22165657801841 1.0000005353042178 0.760975333188903 0.8510005537031262 0.04714806434766799 3.500728535346976e-07 5.1114855934595847e-08 0.04565101904129956 0.015216972335368093 8.092682582969988e-11 10.09190749348463 -0.23902520211531486 (ac)ADEK(ub)PK(ub)EGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADEKPKEGVK 10 2 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 2 5660000.0 1547100.0 979580.0 3133320.0 True False 2028263.0821377109 833430.4823729343 2809114.1033277637 1.0 0.4109084712494648 1.3849850781522217 20.95181336302597 -6.742972897493406 1.6758262741353884 0.6507077609041294 1.3859339872819778 0.6182242941740034 0.24750082330076553 0.3124552363254011 1.7240672799779275 0.1167845302301141 0.2856472954262155 1.80728690772708e-07 6.742972897493406 0.7352262263778484 (ac)ADEK(ub)PK(ub)EGVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADEKPKEGVK 10 2 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 2 8724700.0 1675050.0 2065950.0 4983700.0 True False 1621876.454626012 2890894.608786922 3678319.4622047646 1.0 1.7824382372290697 2.2679406015872816 20.62923249671734 -8.749522137596154 0.14740575247963728 8.177978569124543e-10 3.1509820179655468 0.999876751879276 0.0057989197452470095 0.29481372714025444 0.042716808600735866 0.47839813550640775 0.35168458834855687 1.780237161267852e-09 8.749522137596154 3.150982017147749 (ac)ADEK(ub)PK(ub)EGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADEKPKEGVK 10 2 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 2 4566600.0 1547100.0 720900.0 2298600.0 True False 2119104.678805454 689048.2543024943 1755718.0211529946 1.0 0.325160083498524 0.8285187790452608 21.01502342454886 -9.962297399890591 6.642278170516314 1.0000000541746212 0.5768394312721519 0.48514922413108463 0.20549532694709138 1.6487624133316792e-07 2.588920713870089e-08 0.1989700214311941 0.06632333158245877 1.0906931864472638e-10 9.962297399890591 -0.42316062290246936 (ac)ADEK(ub)PK(ub)EGVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADEKPKEGVK 10 2 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 2 5322250.0 1675050.0 1553400.0 2093800.0 True False 1392878.2922969824 1545031.5258742424 2531603.899362618 1.0 1.1092365603073226 1.8175341760749062 20.409637772151616 -6.934215860049482 0.7113357534024994 0.9907286693996057 1.9798941730937245 0.9973039068978217 0.01881703881344013 0.09050699074376244 0.06738419309613901 0.01759553489197568 0.06266958626519693 1.1635475604834315e-07 6.934215860049482 0.9891655036941188 (ac)ADEK(ub)PK(ub)EGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADEKPKEGVK 10 2 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 2 51169980.0 2401420.0 4291660.0 44476900.0 True False 3108685.529065094 4052825.3483276665 36382560.571532406 1.0 1.3037103014876237 11.703519134170543 21.56787325206791 -6.91314182748591 0.8740619420964054 0.7091089158637304 13.141934206865116 0.9920542850336729 0.44352292201576404 0.10237696900491697 0.12776736380471604 0.36885604150497087 1.0418057964747502 1.2214007223712894e-07 6.91314182748591 12.432825291001386 up (ac)ADEKPK(ub)EGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADEKPKEGVK 10 2 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 1 74909600.0 8532200.0 24616400.0 41761000.0 True False 11185796.825942345 20943729.07397568 37439972.31979844 1.0 1.8723502133886898 3.3470992636811387 23.41516469538632 -6.963194401937804 0.3878019667563512 0.907178377302755 4.365073574649816 0.9998709391540953 0.011004478247139442 0.07857922923105194 0.017054950787731726 0.01906632851592808 0.12417059080841457 1.0884427678963001e-07 6.963194401937804 3.4578951973470615 (ac)ADEKPK(ub)EGVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADEKPKEGVK 10 2 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 1 111207300.0 24845100.0 25100200.0 61262000.0 True False 24056405.900020156 35122840.7558138 45215644.3793945 1.0 1.4600202915508826 1.8795677362326437 24.51991777981199 -6.972224161327853 0.1979799116065577 0.7436724110706209 2.607474102929768 0.9999949303082513 0.0008087728807086552 0.07558740214338862 0.006376687817354358 0.0138505171265394 0.04477039826531461 1.0660457391271462e-07 6.972224161327853 1.8638016918591473 (ac)ADEKPK(ub)EGVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADEKPKEGVK 10 2 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 1 214868000.0 10719000.0 18410000.0 185739000.0 True False 16261506.663867587 15124591.662013458 149027605.2377042 1.0 0.930085506505968 9.164440191070211 23.95495759664231 -6.9049838059716855 0.9292079793249828 0.7028664102946114 10.121907799464745 0.9888872228741885 0.40747298775824514 0.1078296461266049 0.1574472280991611 0.3255415060942049 0.8702900861618348 1.2445610182569665e-07 6.9049838059716855 9.419041389170134 up (ac)ADEKPK(ub)EGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADEKPKEGVK 10 2 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 1 70078200.0 8532200.0 14366000.0 47180000.0 True False 11686784.914035242 13731262.617990883 36037055.70260082 1.0 1.1749392770547464 3.0835731099425066 23.47837475690921 -6.924813812855621 0.7881993396547761 0.9647340819822676 3.428231151071185 0.9954170875280555 0.06388440994946552 0.0954213378772294 0.0915377833551631 0.056496536279405596 0.17787610481633903 1.18901186153394e-07 6.924813812855621 2.4634970690889175 up (ac)ADEKPK(ub)EGVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADEKPKEGVK 10 2 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 1 100438350.0 24845100.0 28162200.0 47431050.0 True False 20659801.474551678 28010484.638840992 57348663.25860325 1.0 1.3557964084671257 2.7758574219236407 24.300323055246267 -6.944925058035013 0.6120304653825567 0.9843357137739741 3.2215287316407637 0.9987404234941859 0.027226962327018555 0.0855898642838593 0.044905363702045384 0.027622638458433726 0.11982936646296168 1.1352066903236345e-07 6.944925058035013 2.2371930178667894 up (ac)ADEKPK(ub)EGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADEKPKEGVK 10 2 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 1 1414447840.0 10719000.0 27356100.0 1376372740.0 True False 13875956.803078488 25833708.98705547 1125887024.0969148 1.0 1.8617605512669269 81.1394154705878 23.72608391873476 -6.903959053439801 0.9376156510088193 7.820441202619669e-14 90.10692956014806 0.9904579042434308 3.670620551248429 0.10235064964247097 0.15296015866942922 2.9992196369928967 7.954537146333311 1.2475011267712193e-07 6.903959053439801 90.10692956014798 up (ac)ADELSEK(ub)QVYDAHTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADELSEKQVYDAHTK 15 1 C9JKI3;Q03135-2 C9JKI3 CAV1 Caveolin 1 124092000.0 44945000.0 50078000.0 29069000.0 True False 58923330.24799918 42606557.602515146 26061218.729537614 1.0 0.7230846834893877 0.44229032235364124 25.812335635598515 -6.970952052434455 0.2343340993109835 1.1081826771246992 0.04912704467233865 0.9999888851415758 0.0007590588750230593 0.07599497508561359 0.007916215689295583 0.006989991950647732 0.02765908823693155 1.0691729129778465e-07 6.970952052434455 -1.0590556324523606 down (ac)ADELSEK(ub)QVYDAHTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADELSEKQVYDAHTK 15 1 C9JKI3;Q03135-2 C9JKI3 CAV1 Caveolin 1 70194000.0 33337000.0 17834000.0 19023000.0 True False 32278735.182751182 24955209.20308137 14040305.622232726 1.0 0.7731160797284494 0.4349707490935226 24.94408071304648 -6.965363828108657 0.35175223405321254 1.032025866937463 0.16461996040315494 0.9999204494923771 0.0020706357681311324 0.07783771585496872 0.014425833441946827 0.0046213008508130425 0.02903106258897877 1.0830192397271208e-07 6.965363828108657 -0.8674059065343079 down (ac)ADELSEK(ub)QVYDAHTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADELSEKQVYDAHTK 15 1 C9JKI3;Q03135-2 C9JKI3 CAV1 Caveolin 1 150468000.0 64448000.0 44752000.0 41268000.0 True False 97772327.77991775 36765655.951028034 33111361.711593084 1.0 0.37603334998616683 0.3386578029125547 26.542922865342668 -13.817289292982249 0.4019674642005882 9.99999699162188 0.3365343478791398 0.999837431833487 0.003867574336850911 23.19809702173856 0.20888874946053432 181.20399119934524 0.009515321893314032 1.5230378872230427e-14 13.817289292982249 -9.66346264374274 (ac)ADELSEK(ub)QVYDAHTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADELSEKQVYDAHTK 15 1 C9JKI3;Q03135-2 C9JKI3 CAV1 Caveolin 1 104505000.0 44945000.0 23038000.0 36522000.0 True False 61562381.09295537 22020104.98352178 27896255.794200607 1.0 0.3576876753722828 0.4531380251858516 25.875545697121407 -10.788306207078158 7.194703503539884 1.0178295936479633 0.4054128502790672 0.9810385580555187 0.038967442135567174 0.010557290121598688 0.00031063271407723926 0.0357422494154783 0.012576687869612743 1.6281476732664277e-11 10.788306207078158 -0.6124167433688961 (ac)ADELSEK(ub)QVYDAHTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADELSEKQVYDAHTK 15 1 C9JKI3;Q03135-2 C9JKI3 CAV1 Caveolin 1 79279000.0 33337000.0 30106000.0 15836000.0 True False 27721192.579507783 29943813.002426863 19147234.38260888 1.0 1.0801776625065582 0.6907074552327523 24.724485988480755 -6.853041178103493 1.220346237012803 1.042922818349588 0.6742017198832291 0.9446153656408123 0.0395184443787632 0.15413998121607783 0.44021219667749156 0.025318754622926737 0.058713760961631285 1.4026807015608476e-07 6.853041178103493 -0.3687210984663589 (ac)ADELSEK(ub)QVYDAHTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADELSEKQVYDAHTK 15 1 C9JKI3;Q03135-2 C9JKI3 CAV1 Caveolin 1 142300000.0 64448000.0 47281000.0 30571000.0 True False 83429206.46000582 44649770.78666073 25007391.684949186 1.0 0.535181535114623 0.29974385165628054 26.314049187435117 -9.914387062282316 0.16490248399629295 1.6615552999153766 7.83592476617278e-12 0.9996633518136557 0.005338265434867299 1.4296342905767434 0.07397716131689117 0.5980292901718484 0.17819625409359 1.2179036659396145e-10 9.914387062282316 -1.6615552999075407 (ac)ADHSFSDGVPSDSVEAAK(ub)NASNTEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADHSFSDGVPSDSVEAAKNASNTEK 25 1 Q99733;Q99733-2;C9J6D1;C9JZI7;E9PKT8;E9PNW0;E9PJJ2;E9PS34;E9PNJ7;E9PKI2;E9PP22;C9J1B1 Q99733 NAP1L4 Nucleosome assembly protein 1-like 4 1 12787600.0 3071900.0 3028000.0 6687700.0 True False 2974384.215973043 4237096.190811399 4935990.743300525 1.0 1.4245288715752789 1.6595000460240674 21.504159588831566 -10.394422598510987 0.1147335680770311 7.487765182222319e-16 2.174733613548953 0.9998640574982349 0.003182109051740063 2.2146440082838437 0.06021755361440726 0.929390611146725 0.3073575892720599 4.032528091724553e-11 10.394422598510987 2.174733613548952 (ac)ADHSFSDGVPSDSVEAAK(ub)NASNTEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADHSFSDGVPSDSVEAAKNASNTEK 25 1 Q99733;Q99733-2;C9J6D1;C9JZI7;E9PKT8;E9PNW0;E9PJJ2;E9PS34;E9PNJ7;E9PKI2;E9PP22;C9J1B1 Q99733 NAP1L4 Nucleosome assembly protein 1-like 4 1 30101300.0 6522700.0 9528600.0 14050000.0 True False 8443763.731639152 8998325.033687415 11493044.165174054 1.0 1.0656770274102172 1.3611281095075072 23.009454779941812 -6.94218763464616 0.6388907611524204 0.996767965085266 1.4462047114541776 0.9984365925444872 0.006210249641897783 0.08678271180938851 0.05017078899360688 0.006150555660261002 0.025193996721832663 1.1423846668686989e-07 6.94218763464616 0.4494367463689116 (ac)ADK(ub)EAAFDDAVEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADKEAAFDDAVEER 14 1 Q09028-3;Q09028;E9PNS6;E9PNS2;E9PIC4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 55269900.0 22987000.0 22514000.0 9768900.0 True False 30136179.60642469 19154998.958884668 8758107.937905664 1.0 0.6356147066100256 0.29061772435277544 24.844993200848332 -7.498190436420374 0.2870251403184524 1.0981397969137754 2.8774102914245557e-11 0.9997583272409019 0.004502692241054714 0.12426778302256844 0.029323395528029508 0.02354451774215827 0.06486528243018265 3.175481329256172e-08 7.498190436420374 -1.0981397968850013 down (ac)ADK(ub)EAAFDDAVEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADKEAAFDDAVEER 14 1 Q09028-3;Q09028;E9PNS6;E9PNS2;E9PIC4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 68838000.0 28141000.0 26337000.0 14360000.0 True False 27247679.35860463 36853501.44564062 10598685.209234204 1.0 1.3525372550305845 0.38897570210459825 24.69963002729744 -6.8076735685933265 1.4241665981177427 1.1926645711821788 0.37298054633818667 0.8537026281333865 0.15225430188739197 0.20998607957018148 0.8398272701145272 0.0840705129933577 0.19469649313015833 1.55713559116681e-07 6.8076735685933265 -0.8196840248439922 down (ac)ADK(ub)EAAFDDAVEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADKEAAFDDAVEER 14 1 Q09028-3;Q09028;E9PNS6;E9PNS2;E9PIC4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 74388000.0 30261000.0 22059000.0 22068000.0 True False 45908149.3754359 18122399.102246355 17706250.127251994 1.0 0.3947534228409372 0.38568860579525094 25.452246940289392 (ac)ADK(ub)EAAFDDAVEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADKEAAFDDAVEER 14 1 Q09028-3;Q09028;E9PNS6;E9PNS2;E9PIC4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 47366000.0 22987000.0 15994000.0 8385000.0 True False 31485915.100317407 15287332.194914801 6404635.69449571 1.0 0.48552923255391395 0.20341272197710858 24.908203262371224 -8.848916467889794 0.24558446334776232 1.295482062162177 3.0789730350755073e-21 0.999255264215912 0.00899977076779681 0.3578219186445983 0.07716855182298084 0.20512017999727228 0.11509229546855787 1.4160661196279142e-09 8.848916467889794 -1.295482062162177 (ac)ADK(ub)EAAFDDAVEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADKEAAFDDAVEER 14 1 Q09028-3;Q09028;E9PNS6;E9PNS2;E9PIC4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 63933400.0 28141000.0 28389000.0 7403400.0 True False 23400488.357678548 28236062.82222467 8951416.710545996 1.0 1.2066441687298972 0.38253119224363163 24.480035302731718 -6.84027886813938 1.2809780765905874 1.10993193841258 0.3552557743086036 0.9249470304149575 0.09591275698989232 0.1684773782845557 0.5368778151477133 0.05870633094632431 0.13526741090604155 1.444511926324055e-07 6.84027886813938 -0.7546761641039765 down (ac)ADK(ub)EAAFDDAVEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADKEAAFDDAVEER 14 1 Q09028-3;Q09028;E9PNS6;E9PNS2;E9PIC4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 50602800.0 30261000.0 10774000.0 9567800.0 True False 39173461.03348805 10174417.428892842 7826558.573918312 1.0 0.25972730416122997 0.199792368798551 25.22337326238184 -13.93539021109973 0.35667600967346214 9.999972746711354 0.192175688152312 0.999765467328914 0.005573207577551148 20.34497027356787 0.19253466952425058 138.88733429159274 0.01749417321360543 1.1604055275996183e-14 13.93539021109973 -9.807797058559041 (ac)ADKPDMGEIASFDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADKPDMGEIASFDK 14 1 P63313 P63313 TMSB10 Thymosin beta-10 0 38391400.0 2472400.0 18113000.0 17806000.0 False True 3241340.3427556576 15410611.003920993 15963605.927212743 1.0 4.75439459431141 4.925001462093032 21.628159081811667 -10.127211748451895 0.6763940461186636 9.96817261611754e-24 4.897948501876236 0.9997933096438615 0.026041871821852743 1.408761172853955 0.3348164823069202 2.873356912602779 0.027125942740194104 7.460849019729071e-11 10.127211748451895 4.897948501876236 (ac)ADKPDMGEIASFDK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ADKPDMGEIASFDK 14 1 P63313 P63313 TMSB10 Thymosin beta-10 0 50697900.0 17255000.0 4811300.0 28631600.0 False True 16707249.469909467 6732477.180598047 21132125.030411556 1.0 0.40296741798963087 1.2648476380550548 23.99397090492687 -6.7203880918844545 1.7580032214346766 0.6369176101486997 1.2635240960931997 0.5142818038018939 0.2512221856397396 0.3545787291157803 2.141881031902291 0.1134588502808455 0.2846851378419042 1.903758731042517e-07 6.7203880918844545 0.6266064859445 (ac)ADKPDMGEIASFDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADKPDMGEIASFDK 14 1 P63313 P63313 TMSB10 Thymosin beta-10 0 40440400.0 2472400.0 20083000.0 17885000.0 False True 3386513.094097736 19195666.654400043 13660931.353137234 1.0 5.668268842029775 4.033922495958014 21.69136914333456 -9.866614003504543 7.109807453976611 0.999999966315895 4.851095668993918 0.8809976370888958 0.6672191018097418 3.5709779630122084e-07 5.6867701373789205e-08 0.6460321173949106 0.2153440391317043 1.3595212383485884e-10 9.866614003504543 3.851095702678023 (ac)ADKPDMGEIASFDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADKPDMGEIASFDK 14 1 P63313 P63313 TMSB10 Thymosin beta-10 0 16147900.0 13177000.0 2052400.0 918500.0 False True 10957259.340077817 2041343.3138304958 1110554.1033358318 1.0 0.18630053834392482 0.10135327355754133 23.385383656768916 -13.999999999999998 0.3192400057946757 9.305628245396893 0.08434526171995484 0.9996920952473793 0.007108217293484124 17.954554418040697 0.18015419146411193 99.55859358293098 0.028366317463289575 1.0000000000000041e-14 13.999999999999998 -9.221282983676938 (ac)ADNEK(ub)LDNQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADNEKLDNQR 10 1 O00629 O00629 KPNA4 Importin subunit alpha-3 1 3949300.0 1505500.0 2443800.0 0.0 True False 1948899.4278416517 2307800.3817271483 0.0 1.0 1.1841557079643503 0.0 20.89422821215301 -6.921890792234138 1.2555033998451997 1.09727052623704 1.536345875973522e-18 0.9601477686667979 0.103861840633015 0.1212466716707401 0.38231828492944586 0.06809072408623777 0.13272450286222734 1.1970415017285863e-07 6.921890792234138 -1.09727052623704 down (ac)ADPDVLTEVPAALK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADPDVLTEVPAALKR 15 1 P29083;E9PER7;C9J329 P29083 GTF2E1 General transcription factor IIE subunit 1 1 5254700.0 1673900.0 1723300.0 1857500.0 True False 1391922.0163433452 1714016.2408517306 2245894.661890375 1.0 1.2314024929029748 1.6135204670377026 20.408646954514904 -6.9636111978366575 0.38114065671587666 0.9740864873774753 1.884373553587115 0.9998815862126181 0.0027528233212028154 0.07843550089991426 0.016541772702096037 0.004967210225911987 0.03227106848503943 1.0873986817278791e-07 6.9636111978366575 0.9102870662096396 (ac)ADQGEK(ub)ENPMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADQGEKENPMR 11 1 P62913-2 P62913-2 RPL11 60S ribosomal protein L11 1 9265200.0 3402700.0 3606200.0 2256300.0 True False 3294683.1510438155 5046174.466084561 1665307.3424509135 1.0 1.531611458445053 0.5054529574181705 21.651708297562816 -6.7659134391310625 1.5900656091445602 1.306515284487665 0.5005514662713928 0.7146525421670662 0.22383100115693533 0.2731136333627086 1.3620865262824329 0.1109986798639175 0.2652291720639245 1.7142989568414998e-07 6.7659134391310625 -0.8059638182162723 (ac)ADQGEK(ub)ENPMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADQGEKENPMR 11 1 P62913-2 P62913-2 RPL11 60S ribosomal protein L11 1 13700400.0 3095400.0 3292600.0 7312400.0 True False 4695948.104052218 2705009.804798783 5867100.934861231 1.0 0.5760306001815866 1.249396459428162 22.16298503432235 -6.736537035339917 1.6995107222511294 0.7467277704215503 1.2494888627645788 0.5892092600563434 0.1781546299778929 0.3241327789181098 1.8368778103668624 0.08297748975755376 0.20438779372257704 1.834268739473053e-07 6.736537035339917 0.5027610923430286 (ac)ADQGEK(ub)ENPMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ADQGEKENPMR 11 1 P62913-2 P62913-2 RPL11 60S ribosomal protein L11 1 38315800.0 4756300.0 4216600.0 29342900.0 True False 6157124.110689633 3981942.503310709 24002793.283579044 1.0 0.6467211691246401 3.898377367756291 22.553825218934804 -6.879982587395879 1.0798604740415216 0.7810772928354327 4.128776352512816 0.9736729297598128 0.23636410317016587 0.12764716662213002 0.27235956732821565 0.16860964800771902 0.40773546493826174 1.318309593805198e-07 6.879982587395879 3.347699059677383 up (ac)ADQLTEEQIAEFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADQLTEEQIAEFK 13 0 P0DP25;P0DP24;P0DP23;M0QZ52;F8WBR5;G3V479 P0DP25 CALM3;CALM2;CALM1 0 64917900.0 7463900.0 29933000.0 27521000.0 False True 9785245.180510426 25467113.077920128 24673390.92007308 1.0 2.6026034716681155 2.5214892897334686 23.222176569003544 -10.154233730124776 4.604669578144027 0.9998008319822896 2.5620463807232734 0.9979816820450361 0.033114726183955084 8759132.355175428 7.166026850975064 18496.740833836095 0.012118748874693887 7.010778883186613e-11 10.154233730124776 1.5622455487409836 (ac)ADQLTEEQIAEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADQLTEEQIAEFK 13 0 P0DP25;P0DP24;P0DP23;M0QZ52;F8WBR5;G3V479 P0DP25 CALM3;CALM2;CALM1 0 67322000.0 24533000.0 6784000.0 36005000.0 False True 23754213.34368524 9492886.578092638 26574210.37315304 1.0 0.39962959163268624 1.1187156564044862 24.50168009474661 -6.685197830210595 1.8838569681661297 0.6219191501753929 1.1160722769637572 0.34791711708965534 0.2541679164249452 0.42705169762301715 2.934605248710062 0.10809694016593441 0.28316849072035866 2.0644395462457135e-07 6.685197830210595 0.4941531267883643 (ac)ADQLTEEQIAEFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADQLTEEQIAEFK 13 0 P0DP25;P0DP24;P0DP23;M0QZ52;F8WBR5;G3V479 P0DP25 CALM3;CALM2;CALM1 0 54687900.0 7463900.0 21151000.0 26073000.0 False True 10223505.534313265 20216478.882996324 19915094.39029062 1.0 1.9774507692242678 1.9479712045393205 23.285386630526435 -10.045232819703736 5.8925323735119575 0.9999977222868428 1.9627109868818924 0.9992972411432196 0.012034981886597596 3.6010091456356007e-07 5.837619211650373e-08 0.011652848875661974 0.0038842737015073467 9.010879464058445e-11 10.045232819703736 0.9627132645950496 (ac)ADQLTEEQIAEFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADQLTEEQIAEFK 13 0 P0DP25;P0DP24;P0DP23;M0QZ52;F8WBR5;G3V479 P0DP25 CALM3;CALM2;CALM1 0 35484700.0 24533000.0 6342600.0 4609100.0 False True 20400276.496177357 6308431.154892467 5572841.499929434 1.0 0.3092326300613893 0.27317480235984465 24.282085370180887 -13.572562600305348 0.42456828043396727 9.99969798341238 0.2721745705871935 0.9998633409030984 0.003909804492253466 21.018947831360926 0.2174889543730275 173.46788723539095 0.008651567172333185 2.6756998832509405e-14 13.572562600305348 -9.727523412825187 (ac)ADSELQLVEQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADSELQLVEQR 11 0 P07741-2;P07741;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 0 13484200.0 1257000.0 6166300.0 6060900.0 False True 1647939.1728053137 5246312.076049141 5433776.208258088 1.0 3.183559297955311 3.2973160040901766 20.652231561413465 -10.397235114367525 0.5947662075858184 3.844002753499273e-16 3.284461109631688 0.9997757741170089 0.015830291139498694 1.7527323976819944 0.2881812473615005 2.808073732829548 0.019881027939086634 4.00649758809417e-11 10.397235114367525 3.2844611096316876 (ac)ADSELQLVEQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADSELQLVEQR 11 0 P07741-2;P07741;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 0 11167800.0 1257000.0 5531500.0 4379300.0 False True 1721746.8691477308 5287100.039775617 3344999.5345146214 1.0 3.0707766249011654 1.9427940276554154 20.715441622936357 -10.398116115288284 5.9339783658507095 0.9995959031957927 2.5067853262782913 0.7040747288284188 0.4604969669985692 0.002462425133719067 0.00024976360420606513 0.44598010866829096 0.14862475701370648 3.998378326939431e-11 10.398116115288284 1.5071894230824987 (ac)AEAEGESLESWLNK(ub)ATNPSNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEAEGESLESWLNKATNPSNR 21 1 Q9NZ52-2;Q9NZ52;J3QRS8;B7Z1E9 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 30876800.0 16336000.0 5625100.0 8915700.0 True False 15817422.621874308 7871231.764508975 6580410.704733241 1.0 0.4976304896616755 0.41602294267797 23.915011202481793 -13.999999999999998 0.25576525080752577 4.597819354870842 0.3849635325588279 0.9995538186584149 0.005454224807802413 14.234050524605133 0.16002980295908115 26.401549306666073 0.03649171810755883 1.0000000000000041e-14 13.999999999999998 -4.212855822312014 (ac)AEAEGESLESWLNK(ub)ATNPSNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEAEGESLESWLNKATNPSNR 21 1 Q9NZ52-2;Q9NZ52;J3QRS8;B7Z1E9 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 50818000.0 13889000.0 23560000.0 13369000.0 True False 21070628.42191034 19355533.924879797 10726611.290159151 1.0 0.9186025939669127 0.50907885020672 24.328730006731906 -6.93966664697881 0.6626569064029857 1.0046241149930728 0.39971773221506657 0.9981199188190243 0.009314686017609913 0.08791902072667696 0.0553045493952771 0.009044412336052772 0.03529896802838651 1.1490352523322338e-07 6.93966664697881 -0.6049063827780062 (ac)AEAEGESLESWLNK(ub)ATNPSNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEAEGESLESWLNKATNPSNR 21 1 Q9NZ52-2;Q9NZ52;J3QRS8;B7Z1E9 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 31706900.0 16336000.0 10403000.0 4967900.0 True False 13584107.807506362 10346956.974166181 6006664.921025676 1.0 0.7616957345147554 0.44218324870084497 23.69541647791607 -6.967054911386745 0.32083346868008417 1.0433314006992025 0.1502292237065293 0.9999494524856514 0.0016247695843506175 0.07727040277762039 0.012436813116468158 0.004826935699223348 0.028084410511433976 1.0788103108364962e-07 6.967054911386745 -0.8931021769926732 down (ac)AEAEGESLESWLNK(ub)ATNPSNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEAEGESLESWLNKATNPSNR 21 1 Q9NZ52-2;Q9NZ52;J3QRS8;B7Z1E9 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 45063000.0 13889000.0 19563000.0 11611000.0 True False 17979584.293120362 18474301.85274092 9497917.138920719 1.0 1.0275155171307189 0.5282612202861089 24.099856328824355 -6.893862171322499 0.9992377953137229 1.0243949186246022 0.48192232307194977 0.9832579445451002 0.029648774596363427 0.1160660916865315 0.20398228575836697 0.022485191679613787 0.056895251715728914 1.276843966601659e-07 6.893862171322499 -0.5424725955526524 (ac)AEASSANLGSGCEEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEASSANLGSGCEEKR 16 1 U3KQ54;Q6P1K2-3;Q6P1K2-6;Q6P1K2;Q6P1K2-2;Q6P1K2-5;V9GYI0;A0A087WT04 U3KQ54 PMF1-BGLAP;PMF1 Polyamine-modulated factor 1 1 2446960.0 349160.0 0.0 2097800.0 True False 457752.14127024973 0.0 1880739.7795185249 1.0 0.0 4.108642232234072 18.80420710910551 -6.842378049265313 1.271287596051873 0.46808460550307085 4.25028230604694 0.928471732105429 0.4678814368118182 0.16603677516222867 0.5202269086322775 0.28846926668392403 0.6650686380788509 1.437546662583725e-07 6.842378049265313 3.782197700543869 (ac)AEASSANLGSGCEEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEASSANLGSGCEEKR 16 1 U3KQ54;Q6P1K2-3;Q6P1K2-6;Q6P1K2;Q6P1K2-2;Q6P1K2-5;V9GYI0;A0A087WT04 U3KQ54 PMF1-BGLAP;PMF1 Polyamine-modulated factor 1 1 5535880.0 569880.0 1289800.0 3676200.0 True False 551789.4713365409 1804823.8662181422 2713292.936363982 1.0 3.270855933235749 4.917261160840676 19.07375840340876 -7.986542085609409 0.2429486832084474 1.519209215223242e-20 6.490257522697218 0.9996351440113029 0.03067603585085005 0.10692971412048059 0.045211563253909764 0.3846941855674116 0.5471160584890478 1.031473118974838e-08 7.986542085609409 6.490257522697218 (ac)AEASSANLGSGCEEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEASSANLGSGCEEKR 16 1 U3KQ54;Q6P1K2-3;Q6P1K2-6;Q6P1K2;Q6P1K2-2;Q6P1K2-5;V9GYI0;A0A087WT04 U3KQ54 PMF1-BGLAP;PMF1 Polyamine-modulated factor 1 1 34156800.0 2935200.0 7292600.0 23929000.0 True False 4452912.991863439 5991178.552656128 19199422.6615467 1.0 1.3454515198485748 4.311654572327988 22.086317991697065 -6.928804161198241 0.7565455903922966 0.9528349946176594 4.902458667901074 0.9962979286925482 0.0904401424986936 0.09326351221410342 0.08075762708081168 0.08181672105089538 0.27017658169977293 1.1781371176126922e-07 6.928804161198241 3.9496236732834147 up (ac)AEASSANLGSGCEEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEASSANLGSGCEEKR 16 1 U3KQ54;Q6P1K2-3;Q6P1K2-6;Q6P1K2;Q6P1K2-2;Q6P1K2-5;V9GYI0;A0A087WT04 U3KQ54 PMF1-BGLAP;PMF1 Polyamine-modulated factor 1 1 3072490.0 349160.0 566230.0 2157100.0 True False 478253.8876942102 541212.0863277867 1647637.4068690145 1.0 1.1316417916373136 3.4451103258411857 18.8674171706284 -6.918608229001097 0.8349831835233926 0.9463492503117776 3.8064921557956857 0.9937855089217206 0.08852007644351845 0.09899769543737699 0.10990841881943877 0.07571224290875234 0.22386298439711172 1.2061234769497903e-07 6.918608229001097 2.860142905483908 up (ac)AEASSANLGSGCEEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEASSANLGSGCEEKR 16 1 U3KQ54;Q6P1K2-3;Q6P1K2-6;Q6P1K2;Q6P1K2-2;Q6P1K2-5;V9GYI0;A0A087WT04 U3KQ54 PMF1-BGLAP;PMF1 Polyamine-modulated factor 1 1 3709680.0 569880.0 0.0 3139800.0 True False 473880.4699646013 0.0 3796317.6632050634 1.0 0.0 8.011129185147992 18.854163678843037 -6.875620392550401 1.103975802301841 0.4098524424531621 8.53317700655767 0.9699757676779881 0.6175933828768997 0.13157817588951568 0.29635591646430265 0.4325145426576014 1.035203832568837 1.3316178479101677e-07 6.875620392550401 8.123324564104507 up (ac)AEASSANLGSGCEEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEASSANLGSGCEEKR 16 1 U3KQ54;Q6P1K2-3;Q6P1K2-6;Q6P1K2;Q6P1K2-2;Q6P1K2-5;V9GYI0;A0A087WT04 U3KQ54 PMF1-BGLAP;PMF1 Polyamine-modulated factor 1 1 55055900.0 2935200.0 5941700.0 46179000.0 True False 3799674.261441928 5611039.171825929 37774895.83655319 1.0 1.4767158408196315 9.941614264118025 21.857444313789514 -6.918497157475659 0.8357924304999366 0.8029172255728299 11.260579704756916 0.9937532284345771 0.3246320556182117 0.09906437769410249 0.11025441245569222 0.27749980592079165 0.8196740831619591 1.2064319844545e-07 6.918497157475659 10.457662479184085 up (ac)AEDMETK(ub)IK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEDMETKIK 9 1 P14854;A0A494C160 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 1 5009400.0 1018700.0 1367700.0 2623000.0 True False 986361.9261081871 1913829.7424612795 1935957.6116867177 1.0 1.9402915824341795 1.9627254058003616 19.911757586753566 -11.028225864902947 0.6364877566839232 2.072951265960698e-10 1.9595264412663589 0.999945339125988 0.0033169166065982352 3.018315833353172 0.3179642755188085 4.406435010242494 0.003731919529895024 9.370745328636721e-12 11.028225864902947 1.9595264410590638 (ac)AEDMETK(ub)IK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEDMETKIK 9 1 P14854;A0A494C160 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 1 27963300.0 4383600.0 2667400.0 20912300.0 True False 6650241.684087141 2191381.6295086765 16778974.738813285 1.0 0.3295190962386025 2.5230623992151173 22.664975341531697 -6.824668317691933 1.3514607991379965 0.6402055836492256 2.5759511395609214 0.894792396712783 0.2976888554540113 0.18749335065244463 0.671560339410261 0.1730302038629654 0.3984173923156471 1.4973788077437634e-07 6.824668317691933 1.9357455559116956 up (ac)AEDMETK(ub)IK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEDMETKIK 9 1 P14854;A0A494C160 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 1 2954220.0 1091400.0 594720.0 1268100.0 True False 1494920.0739760026 568443.3039239558 968600.8973392987 1.0 0.380249963740256 0.6479282164986483 20.51163692200113 -10.391629730673378 5.971096901729112 1.0001132188710005 0.5140890901194858 0.814596933536728 0.10927918908296852 0.0001647450058725152 1.6785100272784375e-05 0.10583351538402459 0.035269706617115516 4.0585440997104904e-11 10.391629730673378 -0.4860241287515147 (ac)AEDMETK(ub)IK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEDMETKIK 9 1 P14854;A0A494C160 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 1 5470000.0 1018700.0 2287400.0 2163900.0 True False 847094.1860618707 2275077.3221866507 2616361.4852568377 1.0 2.6857430491448113 3.0886311443362238 19.692162862187843 -10.026299639592827 0.3444735230107878 2.5647445750545536e-25 3.177607256138463 0.9988477672320752 0.03070982470917687 1.4014972663364276 0.154552206156413 1.5176371468207663 0.12124343362847192 9.412399680137465e-11 10.026299639592827 3.177607256138463 (ac)AEDMETK(ub)IK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEDMETKIK 9 1 P14854;A0A494C160 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 1 25172700.0 4383600.0 3938500.0 16850600.0 True False 5674656.613674313 3719319.0127802524 13783963.701756742 1.0 0.6554262691098786 2.4290392600217077 22.436101663624147 -6.8563133112975105 1.2041902084546972 0.814584515558205 2.5090852439774545 0.9490040150778358 0.17340211643914413 0.15064744170367766 0.4172083451194114 0.11246690554467714 0.26154136984557436 1.392152105963494e-07 6.8563133112975105 1.6945007284192495 up (ac)AEEQPQVELFVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEEQPQVELFVK 12 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 22015700.0 7669100.0 3187600.0 11159000.0 False True 7425648.618353094 4460425.303114399 8236123.1371758 1.0 0.6006782077043203 1.10914528285375 22.82408561781155 -6.69724190645508 1.840513904821129 0.7513742044674925 1.107566878132812 0.40459707937033784 0.16864469036999885 0.401281725231666 2.6407320553830385 0.07315089616935173 0.18878134080039416 2.00797403903772e-07 6.69724190645508 0.3561926736653196 (ac)AEEQPQVELFVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEEQPQVELFVK 12 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 11460100.0 7669100.0 2244400.0 1546600.0 False True 6377196.4487357335 2232308.9717214787 1869986.9093295585 1.0 0.35004550818942226 0.2932302500576534 22.604490893245828 -13.999999999999813 0.3450561523482911 8.753555159637333 0.2848592704826658 0.9997451777186079 0.0051181519154394565 20.177484768536022 0.18875473006428856 114.39904673784896 0.01724339918063675 1.0000000000004295e-14 13.999999999999813 -8.468695889154667 (ac)AEEQPQVELFVK(ub)AGSDGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEEQPQVELFVKAGSDGAK 19 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 9093600.0 2316500.0 3408300.0 3368800.0 True False 2242963.975487992 4769251.964049693 2486410.2181663066 1.0 2.126316791606993 1.1085377408370318 21.096975018637263 -6.621901864639746 2.109385177449644 1.7463248086545595 1.112432623193766 0.0893380366704235 0.48411608426239683 0.5803301024016572 4.909178818719791 0.1883904787054509 0.5368120597604862 2.3883509056974265e-07 6.621901864639746 -0.6338921854607935 (ac)AEEQPQVELFVK(ub)AGSDGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEEQPQVELFVKAGSDGAK 19 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 32337100.0 6514100.0 10855000.0 14968000.0 True False 9882365.944500417 8917840.439497903 12009568.239292543 1.0 0.9023993332751176 1.2152523299317737 23.236425049167575 -6.822879580117663 1.3593364836497188 0.9475412359385105 1.2225152117567348 0.8908846423500905 0.04317278953723262 0.18976620202588534 0.6882012628151344 0.0249526037146182 0.05747328895869199 1.5035588106120244e-07 6.822879580117663 0.27497397581822436 (ac)AEEQPQVELFVK(ub)AGSDGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEEQPQVELFVKAGSDGAK 19 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 23548700.0 6514100.0 7409000.0 9625600.0 True False 8432630.862107817 6996682.636965564 7873839.566996406 1.0 0.829715275265432 0.9337346429306718 23.007551371260025 -10.282890474255112 5.030590939613412 1.0000292016563432 0.8817249591051826 0.6328710104436301 0.04246572902462453 1.3911519433616021e-05 1.9830515911086565e-06 0.041127412164066006 0.013705755108054643 5.213261689984082e-11 10.282890474255112 -0.11830424255116068 (ac)AELIQKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AELIQKK 7 1 O15212;A2AB88 O15212 PFDN6 Prefoldin subunit 6 1 7694500.0 2133100.0 2861400.0 2700000.0 True False 2921764.714860004 2734973.8866155553 2062315.6082454862 1.0 0.9360691751480068 0.7058458875064831 21.47840857416929 -6.9472905537567895 0.587842321401519 1.002678638487236 0.6276948650863642 0.9989710990845958 0.0040519803750023635 0.08459242520598613 0.04060899794940786 0.004210234250703998 0.019274618987580063 1.1290403060330772e-07 6.9472905537567895 -0.37498377340087174 (ac)AELVQGQSAPVGMK(ub)AEGFVDALHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AELVQGQSAPVGMKAEGFVDALHR 24 1 Q96I24;A0A494C1K6 Q96I24 FUBP3 Far upstream element-binding protein 3 1 9058600.0 2762600.0 2916300.0 3379700.0 True False 2674902.7751707863 4080793.798303596 2494455.181173316 1.0 1.5255858404210774 0.9325405036502873 21.35105502407981 -6.672828983568109 1.9272076988891829 1.33465960458901 0.9348997629796606 0.29167002338503667 0.2231129464675777 0.45467204848561177 3.2582797019654453 0.09310928780135075 0.24786301308960232 2.124080717603478e-07 6.672828983568109 -0.3997598416093494 (ac)AENGDNEK(ub)MAALEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AENGDNEKMAALEAK 15 1 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 1 16072800.0 4990800.0 4899700.0 6182300.0 True False 6542987.13097595 4168683.8588810144 5542614.900809121 1.0 0.6371224297760792 0.8471077185173046 22.64151800247311 -10.206197693753156 5.424883512422174 1.000012739163565 0.7421150741466597 0.6678848521079219 0.08572613515127914 1.3208899430256602e-05 1.9329190180347643e-06 0.08300807163477636 0.02766799114795282 6.220170743814002e-11 10.206197693753156 -0.25789766501690525 (ac)AENGDNEK(ub)MAALEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AENGDNEKMAALEAK 15 1 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 1 17901700.0 5398100.0 5285900.0 7217700.0 True False 5226740.270270545 7396587.435604339 5327167.8436413435 1.0 1.4151434839178414 1.0192141886104473 22.31748003929681 -10.637088218155153 9.375564356075122 0.9999140369170394 1.2171788362641338 0.2863154391066235 0.1616374579538056 0.0002905539113034106 1.1246805749003118e-05 0.15656620355482365 0.05216826523153254 2.3062786671911995e-11 10.637088218155153 0.21726479934709442 (ac)AENGDNEK(ub)MAALEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AENGDNEKMAALEAK 15 1 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 1 49897000.0 11265000.0 15104000.0 23528000.0 True False 17089828.581814386 12408573.191909363 18877680.487311248 1.0 0.7260794414938465 1.1046149700646706 24.026634590458674 -6.71258568838254 1.7857798577840625 0.8320431066212751 1.1038013328237168 0.4773713466100189 0.11538386852727833 0.36995272375751426 2.3012991162671423 0.05138494397289709 0.13014440868173238 1.9382701682291666e-07 6.71258568838254 0.2717582262024417 (ac)AENGDNEK(ub)MAALEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AENGDNEKMAALEAK 15 1 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 1 14878600.0 4990800.0 4067700.0 5820100.0 True False 6836033.63129873 3887975.563914907 4445512.248722059 1.0 0.5687472844068291 0.6503057896567848 22.704728063996 -10.841041437104495 7.384251952610952 1.0261698627872002 0.609526537031808 0.9683164346568177 0.0332961203410824 0.012778627668806419 0.0002750813126967342 0.02871838768939427 0.010746276631194172 1.4419777623168291e-11 10.841041437104495 -0.4166433257553922 (ac)AENGDNEK(ub)MAALEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AENGDNEKMAALEAK 15 1 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 1 17635300.0 5398100.0 9617600.0 2619600.0 True False 4488759.326377328 9565788.079855867 3167346.248338105 1.0 2.1310539024991515 0.7056173026978315 22.097885314731087 -6.695227774373072 1.8476924036259788 1.7055647117688917 0.7101802700019406 0.395165822726953 0.4778556028885853 0.4054726328359782 2.687691202865454 0.20658352306362135 0.5344691466984762 2.017308068871206e-07 6.695227774373072 -0.9953844417669511 (ac)AENGDNEK(ub)MAALEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AENGDNEKMAALEAK 15 1 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 1 65899900.0 13596100.0 18138800.0 34165000.0 True False 17600419.46919822 17129359.83471334 27947320.562503308 1.0 0.9732358859225337 1.5878780963949626 24.069106477103688 -6.896720716451906 0.9817770907998385 0.9720946070625165 1.648262984996824 0.9848621887928077 0.03489877328621006 0.11386023762184086 0.19135195827094875 0.026816000106377736 0.06868991480733194 1.2684673221557293e-07 6.896720716451906 0.6761683779343075 (ac)AEPVSPLK(ub)HFVLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEPVSPLKHFVLAK 14 1 Q8IWA4;Q8IWA4-3;Q8IWA4-2;C9JXQ1 Q8IWA4 MFN1 Mitofusin-1 1 8544000.0 2581200.0 2205500.0 3757300.0 True False 3383978.196376356 1876447.996971664 3368530.6385665718 1.0 0.5545094820590183 0.9954350894381276 21.690288842249814 -10.945955139741534 10.55542475175029 1.0605019751834632 0.7749722857485734 0.2577639393330462 0.18000712543426187 0.10309012118367872 0.0005278313858891069 0.07010606549622084 0.05809704991713047 1.1325173400769852e-11 10.945955139741534 -0.2855296894348899 (ac)AEPVSPLK(ub)HFVLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEPVSPLKHFVLAK 14 1 Q8IWA4;Q8IWA4-3;Q8IWA4-2;C9JXQ1 Q8IWA4 MFN1 Mitofusin-1 1 8111000.0 2581200.0 1589600.0 3940200.0 True False 3535539.3943071812 1519366.2158957478 3009605.9109662464 1.0 0.4297409946392297 0.8512437779118578 21.753498903772705 -9.777132159013643 6.111543694287012 1.0000000120808594 0.6404923862749919 0.49237559631452865 0.17207779069883178 2.844049484510517e-08 5.687320761880305e-09 0.16661361185449947 0.05553786813543187 1.6705821664790847e-10 9.777132159013643 -0.3595076258058675 (ac)AEPVSPLK(ub)HFVLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEPVSPLKHFVLAK 14 1 Q8IWA4;Q8IWA4-3;Q8IWA4-2;C9JXQ1 Q8IWA4 MFN1 Mitofusin-1 1 11650100.0 3759800.0 3690600.0 4199700.0 True False 3126440.287381389 3670718.0052732523 5077837.852781155 1.0 1.1740886336734528 1.6241595508079245 21.57608953246434 -6.95473865207471 0.504145235571264 0.9913014048582495 1.8264961170599177 0.9995225942363656 0.005746099409669988 0.0816369061512998 0.028505603232062048 0.006687299429098554 0.037133028510361286 1.1098424907404137e-07 6.95473865207471 0.8351947122016682 (ac)AEQEPTAEQLAQIAAENEEDEHSVNYKPPAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEQEPTAEQLAQIAAENEEDEHSVNYKPPAQK 32 1 P52565;J3KTF8;J3QQX2;J3KRE2;J3KRY1;P52565-2;J3KS60 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 0 31285500.0 8740000.0 3976500.0 18569000.0 False True 8462553.484034125 5564337.187173555 13705221.841940789 1.0 0.6575246109429631 1.6195137635227645 23.012661615991952 -6.81045573711462 1.4126392676085666 0.8134557175934379 1.6365160631068112 0.8610110650712195 0.14842472127940393 0.2061783440138636 0.8108291826441412 0.08261487437387945 0.19106399340765162 1.5471921842856047e-07 6.81045573711462 0.8230603455133733 (ac)AESDWDTVTVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AESDWDTVTVLR 12 0 O60869;O60869-2;O60869-3 O60869 EDF1 Endothelial differentiation-related factor 1 0 5050000.0 716500.0 1928400.0 2405100.0 False True 939338.4385958705 1640690.2368443268 2156243.3233482717 1.0 1.7466444142292759 2.2954914168863767 19.841285521255106 -7.319157574038595 0.12423852960760547 1.3173774140471488e-13 3.867154863159907 0.9999970770833357 0.0009076933932023656 0.11343734062173615 0.007622961436849132 0.08360539180430193 0.14434611753611842 4.7955941965854974e-08 7.319157574038595 3.867154863159775 (ac)AESDWDTVTVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AESDWDTVTVLR 12 0 O60869;O60869-2;O60869-3 O60869 EDF1 Endothelial differentiation-related factor 1 0 4230100.0 716500.0 1802500.0 1711100.0 False True 981409.4126844481 1722859.5899295965 1306973.4212106864 1.0 1.755495278180653 1.331731084212575 19.904495582777997 -10.196492110431416 4.56466679475192 0.9999061711326411 1.543613181093984 0.6869295756569185 0.1730010082775002 20296834.179093383 45338843.31133151 15122.54470241326 0.05922284900409147 6.360743599154704e-11 10.196492110431416 0.5437070099613428 (ac)AESSDK(ub)LYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AESSDKLYR 9 1 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 5681400.0 1755500.0 1831600.0 2094300.0 True False 1699772.6134121194 2562967.431667818 1545740.0023467382 1.0 1.5078295834658282 0.909380460745172 20.696910332484748 -6.681876496858113 1.895117831877388 1.3207760177514818 0.9116224206340485 0.33265860239670997 0.2151443846492431 0.43443847121208207 3.018204086494556 0.09103764204236868 0.23953898182664582 2.0802881880555053e-07 6.681876496858113 -0.40915359711743327 (ac)AETLEFNDVYQEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AETLEFNDVYQEVK 14 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 4716560.0 814460.0 2311900.0 1590200.0 False True 1067764.9472418588 1966973.5317156196 1425661.3582755057 1.0 1.842140947590108 1.3351827684155846 20.0261626631935 -10.471719792098808 5.328867015960213 0.9990989874167712 1.588661858002847 0.6425683167028264 0.2069648099846882 0.0022185781078134393 0.00021994003513548112 0.20067479457470472 0.06679760519347099 3.375049975049977e-11 10.471719792098808 0.5895628705860759 (ac)AETLEFNDVYQEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AETLEFNDVYQEVK 14 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 6053960.0 814460.0 2772100.0 2467400.0 False True 1115587.8719539074 2649619.4558911663 1884650.9376981156 1.0 2.3750880791223232 1.689379191974564 20.08937272471639 -10.08888493273871 6.270027711391993 0.9999979998559773 2.032233635548453 0.7513333801791575 0.2799394809339844 7.827037099692489e-06 1.1369643217241312e-06 0.27105076173631387 0.09035007896693419 8.149201702795937e-11 10.08888493273871 1.032235635692476 (ac)AETLEFNDVYQEVK(ub)GSMNDGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AETLEFNDVYQEVKGSMNDGR 21 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 23063200.0 15392000.0 5259500.0 2411700.0 True False 14903389.385154832 7359645.777930168 1780003.4205508416 1.0 0.4938236254674432 0.11943614801636272 23.829137135374033 -8.126862691531912 0.38038874008836027 1.0790418235126291 2.5917828162366295e-24 0.9976865515048369 0.01735523185109521 0.095222794626093 0.08972209443871891 0.058999141954383855 0.08440677821525816 7.466847962690301e-09 8.126862691531912 -1.0790418235126291 (ac)AETLEFNDVYQEVK(ub)GSMNDGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AETLEFNDVYQEVKGSMNDGR 21 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 35021000.0 18010000.0 11243000.0 5768000.0 True False 27322486.7073659 9236598.808040064 4627952.271795795 1.0 0.3380584976385022 0.16938254271519657 24.70358545812952 -13.999999999999972 0.19197411545879023 4.572940435031952 0.05074724692930206 0.9994884434504532 0.008107863793451249 12.383545431869374 0.1389471265934863 16.562163334119333 0.11420556845783666 1.0000000000000655e-14 13.999999999999972 -4.52219318810265 (ac)AETLEFNDVYQEVK(ub)GSMNDGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AETLEFNDVYQEVKGSMNDGR 21 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 37740300.0 18010000.0 11809000.0 7921300.0 True False 23314300.030174777 11151818.769054707 6479704.679401661 1.0 0.47832526623665944 0.27792833887422036 24.47471178022197 -13.999999997911969 0.13250743668531778 3.4805557057289658 0.00602255769715856 0.9996344166235853 0.005819347509184981 11.933686969964791 0.11344089023181994 7.693309647394859 0.24206295709077336 1.0000000048078693e-14 13.999999997911969 -3.4745331480318074 (ac)AEVEETLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEVEETLKR 9 1 Q9NP97;Q8TF09;H3BNG9;H3BPA0;Q7Z4M1;Q9NP97-2 Q9NP97 DYNLRB1;DYNLRB2 Dynein light chain roadblock-type 1;Dynein light chain roadblock-type 2 1 23439500.0 10959000.0 9355200.0 3125300.0 True False 14367355.127106972 7959440.626283993 2801923.935994492 1.0 0.5539948414908232 0.19502016280700724 23.776291166076135 -7.93178629278714 0.324338765919108 1.0998463377188756 2.8847671313957916e-13 0.9989829326681753 0.01050094996779408 0.10518219027098431 0.06037390437354398 0.0492962001023174 0.08603090478049744 1.1700750187760835e-08 7.93178629278714 -1.0998463377185872 down (ac)AEVEETLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEVEETLKR 9 1 Q9NP97;Q8TF09;H3BNG9;H3BPA0;Q7Z4M1;Q9NP97-2 Q9NP97 DYNLRB1;DYNLRB2 Dynein light chain roadblock-type 1;Dynein light chain roadblock-type 2 1 38309600.0 19260000.0 12614000.0 6435600.0 True False 18648601.84239099 17650835.981141012 4749923.296138409 1.0 0.9464964789487911 0.25470667111038536 24.152564134334813 -6.922347211369815 0.8071428040164849 1.01401203677097 0.13690182018293032 0.9948080528503757 0.02445748886775627 0.09681072022032394 0.09860691910489261 0.02133874748520831 0.06542564580163729 1.1957841390912547e-07 6.922347211369815 -0.8771102165880397 down (ac)AEVEETLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEVEETLKR 9 1 Q9NP97;Q8TF09;H3BNG9;H3BPA0;Q7Z4M1;Q9NP97-2 Q9NP97 DYNLRB1;DYNLRB2 Dynein light chain roadblock-type 1;Dynein light chain roadblock-type 2 1 45805800.0 20380000.0 8329800.0 17096000.0 True False 30917949.97757458 6843282.10897554 13716968.106557012 1.0 0.22133686463491636 0.4436571026379889 24.88194132838906 -10.223313645305774 4.932479951408899 1.0000985058014795 0.33249698364087954 0.9231922656154369 0.09076185710321788 9.83325751770981e-05 1.5483787922608103e-05 0.08789264700036002 0.02929326341888132 5.979795812129943e-11 10.223313645305774 -0.6676015221606 (ac)AEVEETLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEVEETLKR 9 1 Q9NP97;Q8TF09;H3BNG9;H3BPA0;Q7Z4M1;Q9NP97-2 Q9NP97 DYNLRB1;DYNLRB2 Dynein light chain roadblock-type 1;Dynein light chain roadblock-type 2 1 26627200.0 10959000.0 11251000.0 4417200.0 True False 15010838.455839312 10753893.61791838 3373948.3350896207 1.0 0.7164085903366075 0.22476748017877266 23.839501227599026 -7.161481067539113 0.4475838740272018 1.0181056552676053 2.506207081680015e-12 0.9995713846455618 0.0066304292863568984 0.08304636620463936 0.027920095337317267 0.008727862096444999 0.04317931112662767 6.894756492429794e-08 7.161481067539113 -1.018105655265099 down (ac)AEVEETLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEVEETLKR 9 1 Q9NP97;Q8TF09;H3BNG9;H3BPA0;Q7Z4M1;Q9NP97-2 Q9NP97 DYNLRB1;DYNLRB2 Dynein light chain roadblock-type 1;Dynein light chain roadblock-type 2 1 42975200.0 19260000.0 19772000.0 3943200.0 True False 16015543.362669723 19665484.311565284 4767704.888703162 1.0 1.2278999136178625 0.29769235927493415 23.93296940976909 -6.841923626738133 1.2734367312649522 1.121222438225435 0.26591414958314247 0.9277114919268237 0.10643729715105966 0.16656303365353087 0.5238496577254522 0.0655181904106359 0.1510275999897625 1.439051621773013e-07 6.841923626738133 -0.8553082886422925 down (ac)AEVEETLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEVEETLKR 9 1 Q9NP97;Q8TF09;H3BNG9;H3BPA0;Q7Z4M1;Q9NP97-2 Q9NP97 DYNLRB1;DYNLRB2 Dynein light chain roadblock-type 1;Dynein light chain roadblock-type 2 1 50793000.0 20380000.0 11536000.0 18877000.0 True False 26382311.74985913 10894011.459041016 15441579.694376564 1.0 0.4129286152908562 0.5853004786231069 24.65306765048151 -10.888284910350903 11.255122996311451 1.027693085359895 0.49911454695698154 0.9184243451918945 0.07037051852946195 0.03406443485056127 0.0003381130626207506 0.04746386402067462 0.022711987194048867 1.293347088163528e-11 10.888284910350903 -0.5285785384029134 (ac)AEVEQK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEVEQKK 7 1 P62841;K7EJ78;K7EQJ5 P62841 RPS15 40S ribosomal protein S15 1 16874800.0 4782400.0 6607000.0 5485400.0 True False 6269772.71282748 5621261.35388429 4917823.427672281 1.0 0.8965654117546581 0.7843702878751547 22.579981713783692 -6.970086582163878 0.2561313945645795 1.0330245605946966 0.6445992598382538 0.9999830391380873 0.00036259460081249534 0.07627478853563237 0.008930606091251663 0.0024019395402085637 0.010648393563508045 1.0713057054414389e-07 6.970086582163878 -0.38842530075644277 (ac)AEVEQK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEVEQKK 7 1 P62841;K7EJ78;K7EQJ5 P62841 RPS15 40S ribosomal protein S15 1 21382800.0 7525800.0 7766800.0 6090200.0 True False 7286897.598414655 10868123.743326934 4494993.917916298 1.0 1.4914610225470184 0.6168597619505773 22.79687328620308 -6.754220784760796 1.6339149362171108 1.2875187012264862 0.614517369306152 0.6669748192805915 0.2065762889272122 0.2927805365948912 1.539005933098078 0.0998154466846861 0.24129040519967668 1.7610805282565887e-07 6.754220784760796 -0.6730013319203342 (ac)AEVEQK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEVEQKK 7 1 P62841;K7EJ78;K7EQJ5 P62841 RPS15 40S ribosomal protein S15 1 19659600.0 3835100.0 3367500.0 12457000.0 True False 5818127.083365852 2766543.3146024104 9994868.48990294 1.0 0.4755041055242702 1.7178841827773887 22.47212337840236 -6.792024388821108 1.488321148433435 0.7076259794847587 1.7318267724787155 0.8077796634407219 0.22326738867393223 0.23235408572369787 1.0167386876376714 0.1180661026017769 0.27600932831898173 1.6142679012962263e-07 6.792024388821108 1.0242007929939567 (ac)AEVEQK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEVEQKK 7 1 P62841;K7EJ78;K7EQJ5 P62841 RPS15 40S ribosomal protein S15 1 16539500.0 4782400.0 5038800.0 6718300.0 True False 6550582.519500492 4816169.154916636 5131575.907731723 1.0 0.7352276138159217 0.7833770344019765 22.643191775306583 -10.490920037800745 6.148431441148807 1.0001784138854313 0.7593023241089515 0.9708621692433785 0.019656918641082433 4.8109324886987745e-05 3.983373482132876e-06 0.01904671574162771 0.0063442432112221945 3.229088606027818e-11 10.490920037800745 -0.24087608977647978 (ac)AEVEQK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEVEQKK 7 1 P62841;K7EJ78;K7EQJ5 P62841 RPS15 40S ribosomal protein S15 1 22191500.0 7525800.0 9296700.0 5369000.0 True False 6258036.149469362 9246616.831849538 6491633.076548811 1.0 1.477558871665129 1.0373275132166273 22.577278561637357 -10.366822467777256 3.995558089444729 0.9992411881513367 1.2574431924515546 0.3131743160835788 0.17972369953319664 16607187.599530596 43090106.62663057 68368.5433972133 0.06152420201737244 4.297120498687699e-11 10.366822467777256 0.2582020043002179 (ac)AEVEQK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEVEQKK 7 1 P62841;K7EJ78;K7EQJ5 P62841 RPS15 40S ribosomal protein S15 1 18296000.0 3835100.0 3852900.0 10608000.0 True False 4964612.551122894 3638482.7280286998 8677452.847271621 1.0 0.7328835212338473 1.747861038080194 22.24324970049481 -6.836750756419047 1.2973786826777727 0.8577870450720496 1.779158037047733 0.9187264194155816 0.12246601922667395 0.17262725942219065 0.565819894058073 0.07405497668178691 0.1704904972903729 1.4562946149120578e-07 6.836750756419047 0.9213709919756833 (ac)AFK(ub)DTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFKDTGK 7 1 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 1 1403270000.0 560770000.0 584290000.0 258210000.0 True False 735174900.5044047 497116209.5445815 231492906.12521586 1.0 0.6761876788822758 0.31488140572588674 29.45351227173244 -7.22506118362168 0.30326598166265445 1.071236380141698 2.6659965635067645e-11 0.9999034726671843 0.0027493561339542168 0.0934829881817989 0.017557190077766367 0.010523501584605924 0.04239675325449458 5.9557823226211825e-08 7.22506118362168 -1.071236380115038 down (ac)AFK(ub)DTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFKDTGK 7 1 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 1 1663490000.0 596950000.0 807170000.0 259370000.0 True False 578000149.0039095 1129477190.3359437 191433216.06678772 1.0 1.9541122822933807 0.33119925037509446 29.106494623740378 -6.74737752110155 1.6593490110482092 1.5628021971796557 0.3285755247773055 0.6376295826518541 0.4008866778822098 0.30467394519420865 1.6496665178391023 0.1909064939771931 0.46478925601482807 1.7890500024261737e-07 6.74737752110155 -1.2342266724023503 (ac)AFK(ub)DTGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFKDTGK 7 1 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 1 1864480000.0 1222700000.0 326390000.0 315390000.0 True False 1854925291.3434925 268143154.4032904 253053028.25965223 1.0 0.1445573876504097 0.13642222112156874 30.788713936261598 (ac)AFK(ub)DTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFKDTGK 7 1 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 1 1279250000.0 560770000.0 471480000.0 247000000.0 True False 768101823.2394383 450648454.6241365 188663687.12467965 1.0 0.5867040553601929 0.24562327730065553 29.51672233325533 -7.814096092328553 0.2906231888819689 1.117648061683323 2.7810598023079194e-10 0.9994607075701148 0.00716286835031443 0.1181160093496455 0.0460443941479957 0.04413888933827345 0.08388507333092148 1.534277469836176e-08 7.814096092328553 -1.117648061405217 down (ac)AFK(ub)DTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFKDTGK 7 1 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 1 1880510000.0 596950000.0 1065100000.0 218460000.0 True False 496390374.36893487 1059362094.8942027 264138975.95508578 1.0 2.1341310178324435 0.5321194559642455 28.886899899174654 -6.716546014097055 1.7720635272576573 1.6925212565217183 0.5351353855303416 0.49609823659758534 0.47745734556110947 0.36203392199422235 2.219936064842668 0.21411080392921733 0.5396291126121112 1.9206754527680514e-07 6.716546014097055 -1.1573858709913767 (ac)AFK(ub)DTGK(ub)TPVEPEVAIHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFKDTGKTPVEPEVAIHR 18 2 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 2 1375907000.0 477794000.0 593313000.0 304800000.0 True False 626392560.9636782 504793013.11596 273262219.8480534 1.0 0.8058732567630712 0.436247549663826 29.222491838387274 -6.9609950043695275 0.42117697048346775 1.016132591234812 0.21201806682944752 0.9998053380831363 0.003262543846247248 0.07934759247899469 0.01983211050455067 0.004785112668198086 0.030758587882250322 1.0939689499760515e-07 6.9609950043695275 -0.8041145244053645 down (ac)AFK(ub)DTGK(ub)TPVEPEVAIHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFKDTGKTPVEPEVAIHR 18 2 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 2 1746736000.0 786220000.0 628636000.0 331880000.0 True False 761261876.4550697 879653633.0934317 244950671.81341526 1.0 1.1555204067090172 0.3217692615241221 29.50381758979495 -6.858502424615116 1.193346763687994 1.08406028778422 0.28254712153369854 0.9517901364059179 0.07948100623337842 0.14834840060278512 0.40229849441188587 0.05197989166363438 0.12113402029275679 1.385152452759317e-07 6.858502424615116 -0.8015131662505215 down (ac)AFK(ub)DTGK(ub)TPVEPEVAIHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFKDTGKTPVEPEVAIHR 18 2 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 2 1579783000.0 477794000.0 724500000.0 377489000.0 True False 654447353.6973528 692489194.3988861 288333872.82999307 1.0 1.0581281908874913 0.44057611540642305 29.285701899910165 -6.883841879205439 1.058106211066039 1.0382433590389486 0.3934476846333433 0.9766559272608591 0.04254052332935763 0.12428287033357363 0.25216481059176493 0.030854600708261726 0.0754009334970022 1.3066465340120938e-07 6.883841879205439 -0.6447956744056054 down (ac)AFK(ub)DTGK(ub)TPVEPEVAIHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFKDTGKTPVEPEVAIHR 18 2 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 2 1876821000.0 786220000.0 952291000.0 138310000.0 True False 653776765.4516191 947160819.3680356 167229981.52681458 1.0 1.4487526468055976 0.2557906465386463 29.284222865229225 -6.804783186588663 1.436106381482974 1.2461165186906382 0.237272943842661 0.8458327412375187 0.19317108655126636 0.21399897801842263 0.8707380078066018 0.1057905461873457 0.24537087996124743 1.5675334366016258e-07 6.804783186588663 -1.0088435748479772 down (ac)AFK(ub)DTGK(ub)TPVEPEVAIHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFKDTGKTPVEPEVAIHR 18 2 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 2 3026538000.0 1227298000.0 1134110000.0 665130000.0 True False 1588761454.6603816 1070995781.5371879 544083164.8101228 1.0 0.6741073547546049 0.3424574301032673 30.565255380804004 -7.242058504560863 0.2704841954002702 1.0959694146437005 1.6718203784366776e-15 0.9999379125326742 0.002115213224312255 0.09662796885101747 0.01563451045834349 0.01225251387980241 0.042872541185080715 5.727188738388236e-08 7.242058504560863 -1.0959694146436987 down (ac)AGEK(ub)VEKPDTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGEKVEKPDTK 11 2 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 4287200.0 1851600.0 1313900.0 1121700.0 True False 1792821.9715145973 1838547.1218979857 827893.1197213099 1.0 1.0255045682783324 0.46178211382689377 20.77380080400852 -6.896304617744438 0.9843456021992288 1.0258725504973711 0.40685911510161277 0.9846360482227605 0.03221973664607038 0.11417635249316757 0.19316196051490234 0.024710079946767795 0.06317779208365581 1.2696832264854733e-07 6.896304617744438 -0.6190134353957584 down (ac)AGGEAGVTLGQPHLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGGEAGVTLGQPHLSR 16 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 32585500.0 7370500.0 13768000.0 11447000.0 False True 9662796.876023522 11713868.067243654 10262574.247377515 1.0 1.212264752900839 1.0620707833404044 23.204009403845472 -10.206120889860994 5.1402295926039425 0.9999886100744837 1.1371677681206929 0.5265341509965848 0.06131643131128491 8.00437554403591e-06 1.2361100710274768e-06 0.059374308052737156 0.019789793109753 6.221270862715819e-11 10.206120889860994 0.13717915804620917 (ac)AGGEAGVTLGQPHLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGGEAGVTLGQPHLSR 16 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 20454700.0 5390200.0 3556500.0 11508000.0 False True 5219091.051446313 4976628.99690249 8493709.567400217 1.0 0.9535432411211465 1.6274308080995143 22.315367140534228 -6.89037603137762 1.0201317470394269 0.9641170250591068 1.6858253962729866 0.9811386990427053 0.04220479449714168 0.11883955828519138 0.22005823165804747 0.03150697118803013 0.07865627350517919 1.2871346109853354e-07 6.89037603137762 0.7217083712138798 (ac)AGGEAGVTLGQPHLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGGEAGVTLGQPHLSR 16 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 98304000.0 13139000.0 71265000.0 13900000.0 False True 19932823.589565866 58547203.95401357 11152658.907413585 1.0 2.9372258120350283 0.5595122465866608 24.248642754224363 -6.690071507180027 1.8661800763551788 2.2144481662535034 0.5677358253486035 0.3707259891122119 0.8193004560126461 0.41653085226874886 2.8125640132148946 0.35120832513906647 0.9144822335073938 2.04140179740066e-07 6.690071507180027 -1.6467123409048998 (ac)AGGEAGVTLGQPHLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGGEAGVTLGQPHLSR 16 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 32419300.0 7370500.0 8105800.0 16943000.0 False True 10095573.030273153 7747658.953703914 12941412.352038266 1.0 0.7674313216764762 1.2818898256920552 23.267219465368363 -6.783773331018625 1.5208333586879967 0.8689591261271798 1.2864825654805423 0.7806194103288006 0.09852310233956432 0.2447563332540116 1.1183020033694506 0.05100847037938232 0.12000164883389987 1.6452301853044555e-07 6.783773331018625 0.41752343935336245 (ac)AGGEAGVTLGQPHLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGGEAGVTLGQPHLSR 16 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 12022800.0 5390200.0 3833300.0 2799300.0 False True 4482190.126347995 3812649.2520495267 3384620.6874991828 1.0 0.850621938064908 0.7551265323626306 22.095772415968504 (ac)AGGEAGVTLGQPHLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGGEAGVTLGQPHLSR 16 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 38769000.0 13139000.0 25630000.0 0.0 False True 17008694.50841016 24203667.96941929 0.0 1.0 1.4230173842825788 0.0 24.019769076316813 -6.8527682074445355 1.3998227195070074 1.22459280005622 2.6460474874634413e-20 0.8989967014731078 0.18962146751261216 0.17202513790682086 0.6774531882670811 0.10900238539755792 0.2294820727357578 1.403562617052038e-07 6.8527682074445355 -1.22459280005622 down (ac)AGITTIEAVK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGITTIEAVKR 11 1 P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;Q5VU61 P06753-2 TPM3 Tropomyosin alpha-3 chain 1 97981000.0 20965000.0 51092000.0 25924000.0 True False 27485318.025348783 43469272.75505618 23241633.160567354 1.0 1.5815451986026117 0.845601755058187 24.71215783672671 -6.696038767686401 1.8447339678292087 1.3624987811715026 0.8479258990411617 0.3989549120408674 0.2456583496404941 0.40380188939786094 2.6686259673949597 0.10634586897303609 0.27486545584349464 2.0135445009841634e-07 6.696038767686401 -0.5145728821303409 (ac)AGITTIEAVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGITTIEAVKR 11 1 P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;Q5VU61 P06753-2 TPM3 Tropomyosin alpha-3 chain 1 150771000.0 49671000.0 55905000.0 45195000.0 True False 48094221.29353078 78228158.04072368 33357073.6790626 1.0 1.6265604460726815 0.6935775812956038 25.519360223238 -6.725757630800983 1.73866822948096 1.3788292257445451 0.6945445425780405 0.5395166407744705 0.26349015462600167 0.3442428921101303 2.036652788065013 0.12019363759343923 0.299698991944531 1.8803659105697247e-07 6.725757630800983 -0.6842846831665046 (ac)AGITTIEAVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGITTIEAVKR 11 1 P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;Q5VU61 P06753-2 TPM3 Tropomyosin alpha-3 chain 1 279494000.0 115850000.0 97088000.0 66556000.0 True False 175752919.76948068 79761887.84799367 53401177.4274689 1.0 0.4538296601422621 0.3038423344403634 27.388973415975432 -13.999999999999998 0.18134435323748546 3.845624079436605 0.18633870087315563 0.999496578549521 0.006712114408111406 12.222442877337667 0.13500755207765708 12.25885377424514 0.11071964831198061 1.0000000000000041e-14 13.999999999999998 -3.659285378563449 (ac)AGITTIEAVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGITTIEAVKR 11 1 P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;Q5VU61 P06753-2 TPM3 Tropomyosin alpha-3 chain 1 88848000.0 20965000.0 45635000.0 22248000.0 True False 28716327.05782195 43618694.80523556 16993480.611942843 1.0 1.5189510384599967 0.5917706877249833 24.775367898249602 -6.754831351600666 1.6321012783690487 1.3033663393891741 0.5892416547056674 0.6694562809844034 0.21813874906760622 0.29168392090730544 1.5300823512455268 0.10552300033789956 0.2548817706071472 1.7586063962351067e-07 6.754831351600666 -0.7141246846835068 (ac)AGITTIEAVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGITTIEAVKR 11 1 P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;Q5VU61 P06753-2 TPM3 Tropomyosin alpha-3 chain 1 140561000.0 49671000.0 69995000.0 20895000.0 True False 41303637.29839914 69617923.04208025 25264047.89243576 1.0 1.6855155525195966 0.6116664183813891 25.299765498672276 -6.734285898257054 1.707882230987836 1.4105628452645256 0.6118205458819522 0.5789136192070664 0.2880893859512416 0.32825225898300114 1.8776725164531585 0.13357906672768433 0.32983589649646855 1.8438012358797386e-07 6.734285898257054 -0.7987422993825734 (ac)AGITTIEAVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGITTIEAVKR 11 1 P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;Q5VU61 P06753-2 TPM3 Tropomyosin alpha-3 chain 1 259215000.0 115850000.0 115500000.0 27865000.0 True False 149970108.74490583 109072323.46734005 22793855.91904452 1.0 0.7272937546032486 0.1519893271386241 27.16009973806788 -7.228208368197365 0.5483857747697141 1.0056380213959124 1.1228330580553794e-25 0.9984251675056276 0.014027137458305396 0.09100890182302113 0.04852563532816978 0.014413217026934778 0.05273908117647368 5.912778795541403e-08 7.228208368197365 -1.0056380213959124 down (ac)AGK(ub)QAVSASGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGKQAVSASGK 11 1 P14927;B7Z2R2;P14927-2 P14927 UQCRB Cytochrome b-c1 complex subunit 7 1 4414410.0 797610.0 1119500.0 2497300.0 True False 1092507.9715997793 1070036.7883085618 1907489.1735079486 1.0 0.9794315612559672 1.7459727737407513 20.05921237586516 -6.900736956869309 0.9566208315564013 0.9687704201372819 1.827642328925083 0.9869284599986187 0.04077058634075952 0.11086473127203207 0.1743874199373434 0.031920554539266906 0.08336095360008491 1.2567909453399492e-07 6.900736956869309 0.8588719087878011 (ac)AGK(ub)QAVSASGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGKQAVSASGK 11 1 P14927;B7Z2R2;P14927-2 P14927 UQCRB Cytochrome b-c1 complex subunit 7 1 3155000.0 1308300.0 1516000.0 330700.0 True False 1087909.417517174 1507833.007097559 399847.8410159605 1.0 1.3859913176767367 0.3675378065285002 20.053127007953666 -6.8040066985066225 1.4394417765942689 1.2119005579908277 0.3520396613083648 0.8436282779148511 0.16601335471573408 0.21509169973975434 0.8793841792729151 0.09071264022258303 0.21047610630301877 1.5703385834305458e-07 6.8040066985066225 -0.859860896682463 down (ac)AGLNSLEAVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGLNSLEAVKR 11 1 P67936;A0A2R8Y5V9;A0A2R8YGX3;A0A590UJB9;A0A590UK79 P67936 TPM4 Tropomyosin alpha-4 chain 1 23181900.0 7863300.0 11395000.0 3923600.0 True False 6538682.353254454 11333612.873269597 4744006.6193233235 1.0 1.733317549464472 0.725529451199311 22.640568508724993 -6.7115884602665465 1.7896932956576583 1.4500948792340205 0.7277991446948125 0.47259689505814073 0.30893992909448775 0.37188056405705133 2.322914823284604 0.13732522027717778 0.3481806073370135 1.9427259429406701e-07 6.7115884602665465 -0.7222957345392079 (ac)AGTVVLDDVELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGTVVLDDVELR 12 0 P25205 P25205 MCM3 DNA replication licensing factor MCM3 0 6562280.0 592780.0 3107900.0 2861600.0 False True 777140.3204896855 2644213.4344993173 2565509.0824054778 1.0 3.40249162832417 3.3012173152834476 19.56781558966857 -10.236123348903766 4.087757880111122 0.9982306612188114 3.3518544720150945 0.9986112136199982 0.04134506593646265 2331719.24004617 1168173.1257356312 35282.10738208911 0.014153515699456345 5.8059949145150126e-11 10.236123348903766 2.3536238107962832 (ac)AHCVTLVQLSISCDHLIDKDIGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AHCVTLVQLSISCDHLIDKDIGSK 24 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX45;Q5JX52;Q5JX61;Q5JX55;Q5JX54;E7EV27;Q5JX57;Q5JX53 Q99829 CPNE1 Copine-1 0 60906000.0 11182000.0 22877000.0 26847000.0 False True 16963911.51370161 18794420.611183174 21540678.682541866 1.0 1.1079060743745968 1.2697943316400606 24.015965526965147 -6.96525431105784 0.35366199592230807 0.9850001045254815 1.398193844881437 0.9999182878968186 0.0010022402020180088 0.07787477966600477 0.014556344259694242 0.002202334079599564 0.013881603334660002 1.0832923816487354e-07 6.96525431105784 0.4131937403559556 (ac)AHCVTLVQLSISCDHLIDKDIGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHCVTLVQLSISCDHLIDKDIGSK 24 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX45;Q5JX52;Q5JX61;Q5JX55;Q5JX54;E7EV27;Q5JX57;Q5JX53 Q99829 CPNE1 Copine-1 0 44086000.0 11182000.0 14248000.0 18656000.0 False True 14475319.430172948 13455086.2750014 15260799.42672506 1.0 0.9295191266698452 1.0542633964204495 23.787091849057596 -6.753406996060238 1.637121166507232 0.9587271031661256 1.0545789675078838 0.6635439156401914 0.029623004597147822 0.29414057952950756 1.55203444907627 0.014287551147506555 0.03456470463744009 1.7643835658544596e-07 6.753406996060238 0.09585186434175819 (ac)AHQTGIHATEELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHQTGIHATEELK 13 0 D6RG15;Q6IBS0 D6RG15 TWF2 Twinfilin-2 0 8015680.0 744080.0 3841200.0 3430400.0 False True 975496.0856809691 3268107.932880329 3075455.114720349 1.0 3.3502009704108096 3.152708821556626 19.895776558260366 -10.15668295958214 4.991405110895281 0.9998609643760888 3.2514548959882745 0.9942623319264614 0.08062583216555087 0.00012475291780980518 2.1077182821699902e-05 0.07807024216466042 0.026021875435348354 6.971352458694837e-11 10.15668295958214 2.251593931612186 (ac)AHQTGIHATEELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHQTGIHATEELK 13 0 D6RG15;Q6IBS0 D6RG15 TWF2 Twinfilin-2 0 8183120.0 1968900.0 904220.0 5310000.0 False True 1906398.3472213733 1265279.761445006 3919151.7034145906 1.0 0.6637016672245782 2.0557884500513017 20.862418175200958 -6.842894650742048 1.2688912442178615 0.8211126101758371 2.1042615897447634 0.929320955335278 0.15767337750135368 0.16544047494755282 0.5161777474484565 0.09738777771247596 0.22456648437933494 1.4358376903462502e-07 6.842894650742048 1.2831489795689262 up (ac)AHQTGIHATEELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHQTGIHATEELK 13 0 D6RG15;Q6IBS0 D6RG15 TWF2 Twinfilin-2 0 6620280.0 744080.0 2243000.0 3633200.0 False True 1019186.4840059219 2143896.8433908904 2775112.9881027825 1.0 2.10353735752488 2.7228706734759425 19.958986619783257 -8.991622639569298 0.1912238952840195 1.0278306748350333e-15 3.433290513851855 0.9996329709655186 0.013651188768071046 0.4680275208163756 0.06319658352698902 0.6401767034885147 0.35341697101309766 1.019476831324436e-09 8.991622639569298 3.433290513851854 (ac)AHYK(ub)AADSK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHYKAADSKR 10 2 Q99417;A0A0D9SEI7 Q99417 MYCBP C-Myc-binding protein 2 4200930.0 994240.0 2470800.0 735890.0 True False 1303458.268233857 2102166.2711029667 659747.161955328 1.0 1.6127607015384795 0.506151349861982 20.313912963340076 -6.756399521598312 1.6260599420077897 1.3575146808022944 0.5028168978681988 0.676087242963274 0.2576124931756976 0.28900671729383776 1.505210483156168 0.12505316195450775 0.3015961721342041 1.752267792113797e-07 6.756399521598312 -0.8546977829340956 (ac)AHYK(ub)AADSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHYKAADSKR 10 2 Q99417;A0A0D9SEI7 Q99417 MYCBP C-Myc-binding protein 2 5830540.0 1444400.0 3802700.0 583440.0 True False 1398548.3126245858 5321137.940818529 430619.5611751806 1.0 3.8047580428827765 0.3079046732157993 20.415498661665268 -6.6931729705458745 1.8552633956968574 2.7531806690730236 0.31955430860456474 0.38523359807695523 1.1854669500889667 0.4098994816941161 2.7378687768263155 0.5107218634265707 1.3246009382250672 2.0268752960641715e-07 6.6931729705458745 -2.433626360468459 (ac)AHYK(ub)AADSK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHYKAADSKR 10 2 Q99417;A0A0D9SEI7 Q99417 MYCBP C-Myc-binding protein 2 4058780.0 994240.0 2374500.0 690040.0 True False 1361837.3963257303 2269586.738578545 527066.7638198956 1.0 1.6665622083091154 0.38702620829912165 20.377123024862968 -6.765122270047934 1.5930265775940897 1.3846934030843863 0.3811007618870272 0.71160891921379 0.2806045573332298 0.2743828577722956 1.373366899895611 0.138904875913215 0.3321660100882117 1.717424800135178e-07 6.765122270047934 -1.003592641197359 (ac)AHYK(ub)AADSK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHYKAADSKR 10 2 Q99417;A0A0D9SEI7 Q99417 MYCBP C-Myc-binding protein 2 5000470.0 1444400.0 3171100.0 384970.0 True False 1201082.597769477 3154016.6548859333 465465.4470998319 1.0 2.625978147334112 0.38753824921303903 20.195903937099544 -6.711870136723272 1.788241604902762 1.9976862117212075 0.39243537747102775 0.4740921876747278 0.6849810416088283 0.3713414807615817 2.3158591425159467 0.3046738834513796 0.7723506206734261 1.9414663304840821e-07 6.711870136723272 -1.60525083425018 (ac)AK(ub)AAAIGIDLGTTYSCVGVFQHGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKAAAIGIDLGTTYSCVGVFQHGK 24 1 P0DMV9;P0DMV8;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 57497000.0 22813000.0 14010000.0 20674000.0 True False 22088813.802204885 19604266.061184812 15258859.193294419 1.0 0.8875200921485396 0.6907957724634038 24.39681261040016 -6.962580374240955 0.3973979113141326 1.0111294883023652 0.560033320542659 0.9998542535562027 0.001542671423599582 0.07879191411084661 0.01781747219394856 0.002532452894665819 0.01649855813378927 1.0899827522131471e-07 6.962580374240955 -0.4510961677597062 (ac)AK(ub)AAAIGIDLGTTYSCVGVFQHGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKAAAIGIDLGTTYSCVGVFQHGK 24 1 P0DMV9;P0DMV8;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 63085000.0 22813000.0 17206000.0 23066000.0 True False 18970020.287257772 17113307.862876397 27888993.95486587 1.0 0.9021238566819807 1.4701615250036923 24.177217885834438 -6.862484265452054 1.1730204174132004 0.9464986258642177 1.499015955817593 0.9565950006808126 0.05165689802942307 0.144270179825312 0.3757951611086988 0.03430905243539366 0.08033043141763009 1.3725106863549817e-07 6.862484265452054 0.5525173299533753 (ac)AK(ub)FVIRPATAADCSDILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKFVIRPATAADCSDILR 18 2 E9PD37;P21673;A6NM56;A6NJE6 E9PD37 SAT1 Diamine acetyltransferase 1 1 4897500.0 1850300.0 1636100.0 1411100.0 True False 2425761.218330688 1392000.257467851 1265092.9082269948 1.0 0.5738405936037555 0.5215240884663748 21.210006113976892 -13.999999999999998 0.29583930397401137 4.795791063222458 0.5080882402089781 0.9996405333037856 0.0040628806360835466 16.322302829860092 0.17262274724528648 37.83435857351977 0.019251505112969754 1.0000000000000041e-14 13.999999999999998 -4.28770282301348 (ac)AK(ub)FVIRPATAADCSDILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKFVIRPATAADCSDILR 18 2 E9PD37;P21673;A6NM56;A6NJE6 E9PD37 SAT1 Diamine acetyltransferase 1 1 41336100.0 5343100.0 14931000.0 21062000.0 True False 8105873.332933203 12266446.393564526 16899086.468197454 1.0 1.5132788152175296 2.084795280421971 22.950536200497613 -6.969736748885785 0.2643974988178427 0.8479206912988136 2.767207567530063 0.9999802561951048 0.0019687666070729716 0.07638821239484107 0.009335322080563747 0.011600154029454532 0.053575650853452984 1.0721690122271482e-07 6.969736748885785 1.9192868762312494 (ac)AK(ub)FVIRPATAADCSDILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKFVIRPATAADCSDILR 18 2 E9PD37;P21673;A6NM56;A6NJE6 E9PD37 SAT1 Diamine acetyltransferase 1 1 7426700.0 1850300.0 2561600.0 3014800.0 True False 2534405.912477366 2448420.0419215797 2302766.3317550016 1.0 0.96607257340568 0.9086020200702821 21.273216175499783 -6.963158285891371 0.388367233853789 1.0035944802945216 0.8690205327486915 0.9998699777171063 0.000430111580380306 0.07859161244127512 0.01709910258012289 0.000742736597264569 0.0048377057034616 1.0885332868546417e-07 6.963158285891371 -0.13457394754583007 (ac)AK(ub)ISSPTETER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKISSPTETER 11 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 55502000.0 21711000.0 21685000.0 12106000.0 True False 28463331.24962305 18449682.527467944 10853387.248951873 1.0 0.6481912593316806 0.38131120892940484 24.762601183983968 -7.7377981405927265 0.19632868184247937 1.2284855236796828 2.6017017765429313e-14 0.9999111934763604 0.0023876874079121276 0.1299492183760891 0.02578106174511758 0.0523240751807023 0.085856908903798 1.828950111811512e-08 7.7377981405927265 -1.2284855236796568 down (ac)AK(ub)ISSPTETER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKISSPTETER 11 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 72199000.0 28551000.0 18750000.0 24898000.0 True False 27644664.133027274 26236972.779958293 18376466.876010653 1.0 0.9490790936617963 0.6647382940730381 24.720497708082203 -6.937374446208046 0.6835532272988407 1.00338276112405 0.5936417312821026 0.9977993742593468 0.00691999467449498 0.08898517050656135 0.06021902107839675 0.006608937077681074 0.02476901565791934 1.1551158784479663e-07 6.937374446208046 -0.4097410298419474 (ac)AK(ub)ISSPTETER ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKISSPTETER 11 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 139417000.0 38822000.0 36525000.0 64070000.0 True False 58895812.26837088 30006828.3788725 51406536.41712141 1.0 0.5094900167458463 0.8728385675857047 25.811661720432966 -9.720444952773713 5.897375450571372 1.0000000087843772 0.6911642921632406 0.49064504796154496 0.1483364247319004 1.7063540317832076e-08 3.991972048675747e-09 0.14362612993209037 0.04787537521723345 1.9035094938709371e-10 9.720444952773713 -0.3088357166211366 (ac)AK(ub)ISSPTETER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKISSPTETER 11 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 53159000.0 21711000.0 17227000.0 14221000.0 True False 29738143.417713914 16465854.177929047 10862292.690688545 1.0 0.5536947598457322 0.3652646548277213 24.82581124550686 -13.99999999999909 0.11800166764499567 3.1306958273230507 0.05625856074024453 0.9997028013103456 0.00458849528317109 11.971854644492803 0.10545625986841235 5.99837529279923 0.27418945683663776 1.0000000000020943e-14 13.99999999999909 -3.074437266582806 (ac)AK(ub)ISSPTETER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKISSPTETER 11 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 79658000.0 28551000.0 35842000.0 15265000.0 True False 23741421.523758218 35648912.03192006 18456840.922614556 1.0 1.501549180458547 0.7774109441654392 24.50090298351648 -6.72042114176734 1.758058459101551 1.3050031399228614 0.778532555739633 0.5143982151913784 0.21104277588447193 0.3544943587312418 2.141559157232624 0.09531292708064719 0.23912928604996858 1.903613860196323e-07 6.72042114176734 -0.5264705841832285 (ac)AK(ub)ISSPTETER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKISSPTETER 11 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 142826000.0 38822000.0 35452000.0 68552000.0 True False 50255844.29602697 33479065.03518743 56076239.40291897 1.0 0.666172571651217 1.1158152885186359 25.582788042525415 -6.707899402070693 1.8028025378174044 0.7943274593229404 1.1146889714885084 0.45503664907587393 0.14072065712997966 0.3793307990964926 2.4019498108342368 0.062149161824516755 0.15828506881053347 1.9592984636195958e-07 6.707899402070693 0.3203615121655681 (ac)AK(ub)NGSEADIDEGLYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKNGSEADIDEGLYSR 16 1 P22314-2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 7576400.0 5219500.0 0.0 2356900.0 True False 6842815.045709909 0.0 2113030.5969812237 1.0 0.0 0.30879551513028025 22.706158522651368 -10.392500816821029 5.849518897538807 1.0002363677242079 0.1543977575651789 0.9090774008514607 0.12606524115484832 0.0003887069053292367 4.0368727269541645e-05 0.12209501526300086 0.04068738162736192 4.050411833343498e-11 10.392500816821029 -0.845838610159029 (ac)AK(ub)NGSEADIDEGLYSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKNGSEADIDEGLYSR 16 1 P22314-2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 12689700.0 3961500.0 3083500.0 5644700.0 True False 3835744.3509154688 4314757.630240074 4166183.7326298226 1.0 1.124881440341633 1.086147394477812 21.87107513849224 -10.086254004674954 4.584658763132482 0.9999931750699088 1.1055144174131621 0.9082072462285727 0.015813108018389255 1.1031856279333837e-06 2.1988614753425668e-07 0.015311966386662244 0.005103658665596034 8.198718877543806e-11 10.086254004674954 0.10552124234325333 (ac)AK(ub)NGSEADIDEGLYSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKNGSEADIDEGLYSR 16 1 P22314-2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 13735200.0 3961500.0 5757800.0 4015900.0 True False 3294162.774206444 5726781.588566181 4855606.122576344 1.0 1.7384634522031928 1.4740030943814084 21.651480413926517 -10.321142772200313 5.329879032242345 0.9998539798249585 1.6062332732923306 0.8751004695212782 0.10796548897631021 0.00018737863551055605 2.3866040449145567e-05 0.10456197318743536 0.034845711730850625 4.773723140309751e-11 10.321142772200313 0.6063792934673721 (ac)AKPTSK(ub)DSGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKPTSKDSGLK 11 2 P49815;P49815-5;X5D2U8;A0A2R8YDZ2;A0A2R8Y7X5;A0A2R8YGU4;A0A2R8Y7C8;A0A2R8YGD6;P49815-3;P49815-2;P49815-4;A0A2R8Y5F1;P49815-6;A0A2R8YEJ8;A0A2R8YGE6;A0A2R8Y5B2;P49815-8;Q5HYF7;A0A2R8Y692 P49815 TSC2;DKFZp686N1252 Tuberin 1 1851800.0 377240.0 658840.0 815720.0 True False 313691.7745656033 655290.6981504998 986283.2805368588 1.0 2.0889635982898778 3.144115850352316 18.258988174644806 -6.971510913951143 0.21911533851805381 0.5079420901299053 4.754901299905223 0.9999918903683676 0.0024928148314594546 0.0758154340053357 0.007250040077515069 0.029425828755840797 0.10714639179327928 1.067797958117606e-07 6.971510913951143 4.2469592097753175 (ac)ALCNGDSK(ub)LENAGGDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALCNGDSKLENAGGDLK 17 1 P49915 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 8414600.0 3168700.0 2782200.0 2463700.0 True False 4154196.3857344463 2367106.6049306616 2208779.957479163 1.0 0.569810953824747 0.5316984928936284 21.98613798917263 -13.999999999999998 0.3430992546115532 6.070713671547099 0.5259416970106658 0.9997413435035156 0.0034151307350146036 19.991550000087525 0.18808734325983523 73.63502594406395 0.011646566974095687 1.0000000000000041e-14 13.999999999999998 -5.544771974536434 (ac)ALCNGDSK(ub)LENAGGDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALCNGDSKLENAGGDLK 17 1 P49915 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 10003400.0 3639200.0 3400500.0 2963700.0 True False 3523675.5879973695 4758337.38337323 2187418.0609058077 1.0 1.3503903139044542 0.6207773690508767 21.748649676008284 -6.776073813273255 1.5508042645925935 1.1994054127179987 0.61565509011974 0.7534064705807962 0.14795196842344896 0.2567056835543084 1.2190687593708238 0.07515853471805159 0.17796021103586013 1.6746582246768928e-07 6.776073813273255 -0.5837503225982588 (ac)ALCNGDSK(ub)LENAGGDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALCNGDSKLENAGGDLK 17 1 P49915 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 36486100.0 6005300.0 8799800.0 21681000.0 True False 9110479.146237895 7229406.936848782 17395740.846880134 1.0 0.7935265336548312 1.9094210707966526 23.119095500818375 -6.858926964234185 1.1911992253057597 0.8882837010563323 1.9623460241580237 0.952315009433166 0.10585572951220547 0.1479137740840764 0.3994377837180514 0.0693409501812459 0.16166629458927745 1.3837990743698573e-07 6.858926964234185 1.0740623231016915 (ac)ALCNGDSK(ub)LENAGGDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALCNGDSKLENAGGDLK 17 1 P49915 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 8705400.0 3168700.0 1858100.0 3678600.0 True False 4340254.020897706 1776002.9980849817 2809790.4431451303 1.0 0.40919333051332474 0.6473792615861627 22.04934805069552 -10.28102455457488 5.657365947139973 1.0000403804627476 0.5282862960497465 0.8394745104382082 0.09723899917305356 4.952948866382516e-05 6.294533905007539e-06 0.09415928864796647 0.03138375203325593 5.235708335785389e-11 10.28102455457488 -0.47175408441300104 (ac)ALCNGDSK(ub)LENAGGDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALCNGDSKLENAGGDLK 17 1 P49915 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 8893600.0 3639200.0 3066700.0 2187700.0 True False 3026156.0438955184 3050179.078407712 2645137.9552180744 1.0 1.0079384652224572 0.8740917245671952 21.52905495144256 -6.892811798698208 1.005578742414949 1.0067144846803153 0.8619239176718135 0.9826385550328564 0.008078451254274026 0.11689226857124747 0.20874820277499306 0.006097388811201905 0.015363459471982623 1.2799358435673415e-07 6.892811798698208 -0.1447905670085018 (ac)ALCNGDSK(ub)LENAGGDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALCNGDSKLENAGGDLK 17 1 P49915 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 36706300.0 6005300.0 7113000.0 23588000.0 True False 7773979.23216039 6717155.2971704835 19295226.033318553 1.0 0.8640562441152527 2.4820269590502115 22.890221822910824 -6.886490104990549 1.0429002046825404 0.9056099990654491 2.6119929901897376 0.9785558571804158 0.10730714257941067 0.12203807977627718 0.2388417202170917 0.07873640637872253 0.19397164293245503 1.298703153276225e-07 6.886490104990549 1.7063829911242885 up (ac)ALDGPEQMELEEGK(ub)AGSGLR ddPTM_RPMI8226_Bortezomib_1h_R1 2 ALDGPEQMELEEGKAGSGLR 20 1 P62195;J3QQM1;J3QSE0;J3KTQ9 P62195 PSMC5 26S protease regulatory subunit 8 1 43808000.0 13470400.0 16191900.0 14145700.0 True False 17659824.847539164 13776131.63553186 12682038.659135863 1.0 0.7800831409407504 0.7181293568097342 24.073967698430092 -13.999999999526379 0.17770785030989478 2.133192474240015 0.6677338774249026 0.9995010801869606 0.0027015194991615444 12.175915838051191 0.13361228456820523 4.761782684063631 0.047173943253140616 1.000000001090553e-14 13.999999999526379 -1.4654585968151124 (ac)ALDGPEQMELEEGK(ub)AGSGLR ddPTM_RPMI8226_Bortezomib_2h_R1 2 ALDGPEQMELEEGKAGSGLR 20 1 P62195;J3QQM1;J3QSE0;J3KTQ9 P62195 PSMC5 26S protease regulatory subunit 8 1 77724800.0 22293800.0 26876800.0 28554200.0 True False 21586095.522009123 37608846.40066045 21074998.412361767 1.0 1.7422718417193408 0.976322855185819 24.363598977490994 -6.653356339465798 1.9970060210221634 1.4803828572226565 0.9795664857927373 0.20766498170111725 0.3165509310500207 0.5003063652780592 3.8283230823405976 0.12840104939207533 0.35059590333889484 2.221486408755992e-07 6.653356339465798 -0.5008163714299192 (ac)ALDGPEQMELEEGK(ub)AGSGLR ddPTM_RPMI8226_Bortezomib_8h_R1 2 ALDGPEQMELEEGKAGSGLR 20 1 P62195;J3QQM1;J3QSE0;J3KTQ9 P62195 PSMC5 26S protease regulatory subunit 8 1 226848200.0 39857000.0 126932000.0 60059200.0 True False 60465982.937006325 104279992.87575753 48188472.795117564 1.0 1.724605932304066 0.7969517810587895 25.84962040081032 -6.698387476246116 1.8376065334677676 1.4506849407264877 0.7998805201020863 0.4095308285085385 0.3059585876259263 0.398856690233319 2.6175832040264346 0.1329161621234526 0.3423821119028178 2.0026844409374733e-07 6.698387476246116 -0.6508044206244014 (ac)ALDGPEQMELEEGK(ub)AGSGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ALDGPEQMELEEGKAGSGLR 20 1 P62195;J3QQM1;J3QSE0;J3KTQ9 P62195 PSMC5 26S protease regulatory subunit 8 1 51813800.0 13470400.0 19886000.0 18457400.0 True False 18450770.903872415 19007370.76579194 14098142.262085292 1.0 1.0301667537264099 0.7640950253805601 24.137177759952984 -6.878717351481108 1.0869642204344558 1.018396353384395 0.7456991128608793 0.9726343805502646 0.019678408585066743 0.12877065436992063 0.27922363342499784 0.013961980198603445 0.0336553353262385 1.3221558426965426e-07 6.878717351481108 -0.2726972405235156 (ac)ALDGPEQMELEEGK(ub)AGSGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ALDGPEQMELEEGKAGSGLR 20 1 P62195;J3QQM1;J3QSE0;J3KTQ9 P62195 PSMC5 26S protease regulatory subunit 8 1 67243900.0 22293800.0 30589800.0 14360300.0 True False 18538282.48279781 30425006.675800104 17362972.33547476 1.0 1.6411987844090907 0.9366009149761498 24.14400425292527 -6.667209216868762 1.947557430264451 1.410256205751226 0.9394976746330316 0.2666593740026111 0.2725442271968209 0.46753183690067424 3.4161809343611704 0.11277706765284377 0.30238078362416 2.1517449041808095e-07 6.667209216868762 -0.47075853111819443 (ac)ALDGPEQMELEEGK(ub)AGSGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ALDGPEQMELEEGKAGSGLR 20 1 P62195;J3QQM1;J3QSE0;J3KTQ9 P62195 PSMC5 26S protease regulatory subunit 8 1 267203300.0 39857000.0 172808300.0 54538000.0 True False 51595672.1989271 163191366.1942958 44612643.607136205 1.0 3.1628886540156222 0.8646586371649966 25.62074672290277 -6.65987247797765 1.97351378613686 2.3923769941787656 0.8742739777027305 0.23502364639418238 0.9209377711923067 0.4847251439175777 3.629112712982271 0.377047687635776 1.0207816290162222 2.1884041113906232e-07 6.65987247797765 -1.5181030164760352 (ac)ALHVPK(ub)APGFAQMLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALHVPKAPGFAQMLK 15 1 P50990 P50990 CCT8 T-complex protein 1 subunit theta 1 12807400.0 2771600.0 6368300.0 3667500.0 True False 3633594.440212584 5418174.463438976 3288022.2811441435 1.0 1.4911335187759656 0.9048952312222762 21.792965973005867 -6.6844791004223465 1.8859110147515876 1.3094924741370046 0.9070418808840475 0.3446979920835621 0.20795434358556875 0.4286894617927016 2.9515604095973567 0.08835476453933847 0.2317064035895486 2.0678588912142032e-07 6.6844791004223465 -0.4024505932529572 (ac)ALHVPK(ub)APGFAQMLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALHVPKAPGFAQMLK 15 1 P50990 P50990 CCT8 T-complex protein 1 subunit theta 1 20835200.0 5202700.0 8990600.0 6641900.0 True False 5037543.136314004 12580593.465359624 4902187.137271067 1.0 2.4973668959120636 0.9731305528547837 22.26428885676723 -6.650206453894485 2.0074632356967204 1.9714574758106664 0.9794913334891677 0.19504709254671748 0.6390545458944156 0.5080047973766872 3.9241746115583473 0.2581339531374043 0.7079888330882218 2.237657153469879e-07 6.650206453894485 -0.9919661423214987 (ac)ALHVPK(ub)APGFAQMLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALHVPKAPGFAQMLK 15 1 P50990 P50990 CCT8 T-complex protein 1 subunit theta 1 18462900.0 5202700.0 11147000.0 2113200.0 True False 4326275.568689608 11086948.898493724 2555060.349667155 1.0 2.5627005775436227 0.5905912161857644 22.044694132201506 -6.695471176367816 1.8463177062352982 1.9746119445581312 0.5967977857778133 0.3964020740259151 0.6601936432831497 0.40503793804012733 2.680870062085825 0.2855689844527907 0.7387336856176343 2.0161777776563444e-07 6.695471176367816 -1.3778141587803179 (ac)ALK(ub)DYALEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALKDYALEK 9 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 9730100.0 2313100.0 4574500.0 2842500.0 True False 3032496.5000922657 3892002.431261338 2548385.3671853403 1.0 1.2834317965883624 0.8403588815709446 21.532074549607323 -6.733928477831174 1.7088287346334763 1.169821596935057 0.840425570982314 0.5773425475722205 0.11911644316370794 0.328958378322351 1.8835777874347344 0.055199229154331515 0.13637223227455436 1.8453192921880559e-07 6.733928477831174 -0.329396025952743 (ac)ALK(ub)DYALEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALKDYALEK 9 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 9692400.0 3551600.0 6140800.0 0.0 True False 3438856.402047552 8592853.463848948 0.0 1.0 2.4987532072384937 0.0 21.713497443147812 -6.74549725179698 1.674451138125442 1.8872778399039911 3.5696892744495887e-07 0.6239043101744521 0.6297405916867227 0.3091646918877973 1.7054011785595484 0.29770270676003363 0.7239545660037702 1.7968124503151476e-07 6.74549725179698 -1.8872774829350636 (ac)ALK(ub)DYALEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALKDYALEK 9 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 71522900.0 5266000.0 5399900.0 60857000.0 True False 7988906.99616819 4436245.655388731 48828587.27542938 1.0 0.5553007010241248 6.1120485316514 22.929566703381948 -6.887525149080403 1.0368688943874627 0.6834777410936239 6.567508170914599 0.9792679893265184 0.36301850690481696 0.12117588951519354 0.23373942587162264 0.2675843835867837 0.6614431040701894 1.2956116691967544e-07 6.887525149080403 5.884030429820975 up (ac)ALK(ub)DYALEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALKDYALEK 9 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 8637200.0 2313100.0 2869800.0 3454300.0 True False 3168315.5791771067 2743002.746840472 2638465.4835416274 1.0 0.8657605842259251 0.8327659974537337 21.595284611130214 -13.99999780680689 0.1970885098521847 1.7381065188529998 0.8107124503961931 0.999487038532027 0.0016380175263400933 12.474829421055956 0.14077833413845803 3.5452986212466873 0.021474650431678444 1.000005050026512e-14 13.99999780680689 -0.9273940684568067 (ac)ALK(ub)DYALEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALKDYALEK 9 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 12148100.0 3551600.0 8596500.0 0.0 True False 2953312.7625575177 8550188.94822834 0.0 1.0 2.895118003290659 0.0 21.49390271858209 -6.730086416498349 1.7227472586904662 2.1403663630661063 0.0016475005459686734 0.5597072189396726 0.7966595342148715 0.33609324803119084 1.9541588496077746 0.36644204876682895 0.9092703577256607 1.8617166529284643e-07 6.730086416498349 -2.1387188625201374 (ac)ALK(ub)DYALEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALKDYALEK 9 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 69541200.0 5266000.0 3825200.0 60450000.0 True False 6816940.808378712 3612324.2573789596 49448720.269378744 1.0 0.5299040081056662 7.253799271456376 22.700693025474397 -6.89012717473094 1.0216066571700455 0.6398189200746952 7.8336104642000866 0.980980392477452 0.4226833793732194 0.11904094796088122 0.22123396967906644 0.31519242217438054 0.7861581055616225 1.28787236798103e-07 6.89012717473094 7.193791544125391 up (ac)ALKDYALEK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALKDYALEKEK 11 2 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 177733400.0 7324000.0 8359400.0 162050000.0 True False 11111043.456121504 6867599.757709685 130020746.47096196 1.0 0.6180877416986483 11.701938434893664 23.405490973133222 -6.898921463078283 0.9680879147146777 0.5254369171073592 12.840116014284797 0.9860212407283421 0.6073953463410644 0.1122026402658248 0.18194294414628226 0.4715175479242862 1.2202672862864583 1.2620557415228313e-07 6.898921463078283 12.314679097177438 up (ac)ALKDYALEK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALKDYALEKEK 11 2 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 259170100.0 7324000.0 6696100.0 245150000.0 True False 9481062.377623567 6323456.148655034 200535215.45141783 1.0 0.666956496729643 21.151133434656515 23.17661729522567 -6.90320543734482 0.9407783846990616 0.22160692407141927 23.446944335175715 0.9880946466190367 1.0451586735310077 0.10908446831511781 0.1644110198697188 0.8279213511320852 2.1909122452760643 1.2496677513366038e-07 6.90320543734482 23.225337411104295 up (ac)AMQAAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 AMQAAKR 7 1 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 1 3825920.0 989820.0 1688000.0 1148100.0 True False 1297663.6054305148 1436156.979772464 1029305.6253528555 1.0 1.10672517419952 0.7931991165086052 20.30748500992159 -6.814834014732418 1.3939697976392296 1.057841770305664 0.7870781461925671 0.8721122371503885 0.04654410939875864 0.2002790417264883 0.7660290677793721 0.0262466615309257 0.06059635975450726 1.5316727478045872e-07 6.814834014732418 -0.27076362411309685 (ac)AMQAAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 AMQAAKR 7 1 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 1 6469100.0 1639800.0 2533500.0 2295800.0 True False 1587745.446581138 3545139.762027963 1694461.1074763145 1.0 2.2328136853811453 1.0672120717618592 20.59854820196099 -6.632955709011437 2.0694637313657647 1.810425119496306 1.0719249244863236 0.12833506513143156 0.5284135049137042 0.5513412593230574 4.503438242431661 0.2085487065913192 0.5853737056666347 2.3283286972957016e-07 6.632955709011437 -0.7385001950099823 (ac)AMQAAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AMQAAKR 7 1 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 1 3647020.0 989820.0 1151200.0 1506000.0 True False 1355783.2028797204 1100336.1774906802 1150313.817043596 1.0 0.8115871144837437 0.84844967440244 20.37069507144448 -10.363797234118406 5.78541619175397 1.0000354571760792 0.8300183944430927 0.965929850166946 0.015049077068930956 6.88400377204654e-06 7.570184483609585e-07 0.014574242516980057 0.004857068738646578 4.327158127036888e-11 10.363797234118406 -0.17001706273298656 (ac)AMQAAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AMQAAKR 7 1 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 1 5968400.0 1639800.0 3075000.0 1253600.0 True False 1363566.355457206 3058434.36466029 1515721.9640084922 1.0 2.242967019844657 1.1115865083810081 20.378953477395267 -6.623772272563901 2.1034218977101835 1.8225696451652023 1.1160353637934712 0.09548551181429032 0.5340106087099711 0.5753299499434349 4.842346037758423 0.208257082767395 0.5917335628737883 2.3780869376945326e-07 6.623772272563901 -0.706534281371731 (ac)AMQAAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AMQAAKR 7 1 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 1 2899210.0 405670.0 703240.0 1790300.0 True False 525147.8119511943 664104.0758023574 1464483.77002926 1.0 1.2646040994341556 2.7887077441833936 19.002364025891847 -6.936706226863741 0.6895347800756682 0.9815322274224791 3.162710781868356 0.9976997307630585 0.03780650363905018 0.0893021048649676 0.06169873012069528 0.03594073110519968 0.13319129952605785 1.1568945445932879e-07 6.936706226863741 2.181178554445877 up (ac)ANNDAVLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANNDAVLKR 9 1 Q12904;A0A5F9ZHC5;D6R937 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 1 6662800.0 2952700.0 2379800.0 1330300.0 True False 3871018.293987478 2024743.1163877428 1192653.3171386647 1.0 0.5230518077201038 0.30809808338831957 21.884281694981432 -11.660964668755968 0.13878281518710064 2.234465684926374 1.3057562957032387e-20 0.999680284686556 0.005169973568652964 4.62524492303779 0.09095714589995822 1.9357840886557158 0.22922252540089152 2.1829074911201768e-12 11.660964668755968 -2.234465684926374 (ac)ANNDAVLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANNDAVLKR 9 1 Q12904;A0A5F9ZHC5;D6R937 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 1 10644900.0 2738900.0 5040900.0 2865100.0 True False 2651955.118698059 7053757.657946228 2114644.358842401 1.0 2.659832969348732 0.797390703912273 21.33862492902066 -6.671650546965031 1.9312036027128203 2.0579751087362803 0.8048246889536892 0.28638190712118594 0.7047982766954984 0.45742309151356825 3.290438438044767 0.29361928183077796 0.7828834755925594 2.1298521322891674e-07 6.671650546965031 -1.2531504197825911 (ac)ANNDAVLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANNDAVLKR 9 1 Q12904;A0A5F9ZHC5;D6R937 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 1 15468600.0 5236800.0 3953800.0 6278000.0 True False 7944608.461362237 3248213.4988196003 5037150.548254845 1.0 0.40885759375266173 0.6340338322212471 22.921544689493285 -10.20501583633386 5.442484696459411 1.0000225549602697 0.5214457129869069 0.8575947285953772 0.09192781440807815 2.5159839265962148e-05 3.675097922911926e-06 0.08901291160700803 0.029669574521282834 6.237120917142698e-11 10.20501583633386 -0.4785768419733628 (ac)ANNDAVLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANNDAVLKR 9 1 Q12904;A0A5F9ZHC5;D6R937 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 1 9337700.0 2738900.0 5534600.0 1064200.0 True False 2277516.703842993 5504784.011267918 1286719.299695146 1.0 2.417011476569792 0.5649659111276708 21.119030204454937 -6.702239589293035 1.8228052316968275 1.8779603748389855 0.5702217039872455 0.4282626039337891 0.5978952590451769 0.39087462532501605 2.5264192093773747 0.26152122133557065 0.6707298290774556 1.9849995411444514e-07 6.702239589293035 -1.30773867085174 (ac)AQAK(ub)INAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQAKINAK 8 1 O95816 O95816 BAG2 BAG family molecular chaperone regulator 2 1 7252200.0 1203500.0 2088600.0 3960100.0 True False 1577800.1547105801 1776989.021299034 3550346.839961537 1.0 1.1262446742661092 2.2501879147126758 20.589483053467458 -6.928162267615816 0.7617221843603151 0.9816931878141723 2.4704911030553793 0.9961647235076877 0.034801745796794015 0.09360293668894078 0.08243637562724532 0.031366383059906716 0.10274394823626447 1.1798797089369452e-07 6.928162267615816 1.4887979152412072 up (ac)AQAK(ub)INAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQAKINAK 8 1 O95816 O95816 BAG2 BAG family molecular chaperone regulator 2 1 25181900.0 2534300.0 5104600.0 17543000.0 True False 2453850.033705682 7142893.400137332 12947962.021281017 1.0 2.910892394410302 5.276590599845114 21.226615651152933 -6.968250682770134 0.29701249280981795 0.5748660659162849 7.686430780060036 0.9999653416255757 0.010297769648301657 0.07687449645729239 0.011051057747200948 0.03984113050832342 0.21285048791063346 1.075844037385683e-07 6.968250682770134 7.111564714143751 (ac)AQAK(ub)INAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQAKINAK 8 1 O95816 O95816 BAG2 BAG family molecular chaperone regulator 2 1 6856100.0 1203500.0 1315000.0 4337600.0 True False 1648466.473364597 1256898.9518765155 3313148.215676161 1.0 0.7624655837319676 2.009836577940145 20.65269311499035 -6.857399150034523 1.198749802672056 0.8719032890169229 2.0673227935718703 0.9504013570633447 0.12043897601889011 0.1495113440914331 0.4097322057861146 0.07843798611861592 0.18260139088737862 1.3886757446993458e-07 6.857399150034523 1.1954195045549474 up (ac)AQAK(ub)INAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQAKINAK 8 1 O95816 O95816 BAG2 BAG family molecular chaperone regulator 2 1 17953900.0 2534300.0 7031300.0 8388300.0 True False 2107382.7385261594 6993420.991296224 10142254.746882932 1.0 3.318533868312509 4.812725548837001 21.00702092658721 -8.309970775128855 0.2562030243528037 3.2921283347557123e-16 5.989890752202957 0.9993571145224005 0.039772621410128606 0.10506813700133551 0.06178245632935589 0.5298975039855391 0.5364089455963862 4.8981177904234874e-09 8.309970775128855 5.989890752202957 (ac)AQDQGEK(ub)ENPMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 AQDQGEKENPMR 12 1 P62913 P62913 RPL11 60S ribosomal protein L11 1 86260600.0 45016300.0 34537200.0 6707100.0 True False 59016805.238469265 29384384.38495115 6013113.63104619 1.0 0.4978985945819608 0.10188815891929419 25.81462248956691 -8.056727537449651 0.4119283885051376 1.0592861234121065 2.295514853995333e-19 0.9970204280273757 0.02006039108968191 0.09708372185529149 0.09582986291206995 0.05002941314967928 0.08176988190307287 8.775511962020404e-09 8.056727537449651 -1.0592861234121065 (ac)AQDQGEK(ub)ENPMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 AQDQGEKENPMR 12 1 P62913 P62913 RPL11 60S ribosomal protein L11 1 111460200.0 46209600.0 50430400.0 14820200.0 True False 44742701.54185619 70567521.71106176 10938345.023530131 1.0 1.577185088947899 0.24447216298053567 25.41514903244075 -6.78898049069682 1.5002509432357236 1.323009413188182 0.23066082368197144 0.7980723165400547 0.24521738629588183 0.23686198492781438 1.053187267564863 0.12865914296636852 0.30146758573013777 1.6256217800166279e-07 6.78898049069682 -1.0923485895062106 down (ac)AQDQGEK(ub)ENPMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 AQDQGEKENPMR 12 1 P62913 P62913 RPL11 60S ribosomal protein L11 1 171114100.0 44179200.0 26758400.0 100176500.0 True False 67023076.33215212 21983154.45566653 80376570.86608034 1.0 0.3279938143501902 1.1992372666952968 25.998154571393766 -6.700723645779723 1.8284074389282572 0.5830060789934417 1.1966713366780375 0.4209741769122949 0.2836246833278072 0.3940110344616249 2.561371323842258 0.12373240357283743 0.3179091431434936 1.9919404654892773e-07 6.700723645779723 0.6136652576845958 (ac)AQDQGEK(ub)ENPMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AQDQGEKENPMR 12 1 P62913 P62913 RPL11 60S ribosomal protein L11 1 85359000.0 45016300.0 32359900.0 7982800.0 True False 61660042.629765324 30930132.618120804 6097427.050926704 1.0 0.5016236009410382 0.09888781763480774 25.877832551089803 -8.030632087980779 0.4198339232428564 1.0545341976188811 2.0098838090254376e-15 0.9968559259853023 0.02066633440880037 0.09810106669287537 0.09662340141393354 0.04753429896800499 0.08121441120002593 9.31896996527208e-09 8.030632087980779 -1.0545341976188791 down (ac)AQDQGEK(ub)ENPMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AQDQGEKENPMR 12 1 P62913 P62913 RPL11 60S ribosomal protein L11 1 130276400.0 46209600.0 76465300.0 7601500.0 True False 38425329.83237915 76053366.2517264 9190938.50463508 1.0 1.9792508374941769 0.23918958001735424 25.195554307875025 -6.753972232596088 1.6349109028289608 1.5730209351084141 0.23459022188035933 0.6660453834270804 0.41159524473114417 0.29313027924681934 1.5426675655473052 0.1987696411409021 0.48060808591779275 1.7620887051413756e-07 6.753972232596088 -1.3384307132280548 (ac)AQDQGEK(ub)ENPMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AQDQGEKENPMR 12 1 P62913 P62913 RPL11 60S ribosomal protein L11 1 356104160.0 44179200.0 35616400.0 276308560.0 True False 57190845.3022264 33634316.03066815 226023237.2452419 1.0 0.5881066428189126 3.9520877170256297 25.769280893486215 -6.876268357366701 1.100445485662313 0.755408230717412 4.174025562446505 0.970546583821732 0.2571173412515003 0.13098468512881997 0.292724252001159 0.18055341274709966 0.43275757192461145 1.3296325632867234e-07 6.876268357366701 3.418617331729093 up (ac)AQISSNSGFK(ub)ECPSSHPEPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQISSNSGFKECPSSHPEPTR 21 1 O00443;A0A0C4DGF9;O00443-2;E9PPP3 O00443 PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1 8104500.0 2801300.0 3300300.0 2002900.0 True False 3672531.427827785 2807908.1044686437 1795659.121173446 1.0 0.7645702044078775 0.4889431599052471 21.8083434060764 -6.9690482934924605 0.27998462720915673 1.0607331825866895 0.1843814026030194 0.9999739780646739 0.00106537951535354 0.07661272927554774 0.010130727265359756 0.005091610287769029 0.02529959108364271 1.0738699914918666e-07 6.9690482934924605 -0.8763517799836701 down (ac)AQISSNSGFK(ub)ECPSSHPEPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQISSNSGFKECPSSHPEPTR 21 1 O00443;A0A0C4DGF9;O00443-2;E9PPP3 O00443 PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1 6944900.0 1951400.0 1543400.0 3450100.0 True False 1889453.8751423575 2159687.668724672 2546415.3092185836 1.0 1.1430221701294265 1.347699111748218 20.84953786965499 -6.966027103916661 0.3399647307657548 0.9777907783487771 1.519732106419338 0.999932776236322 0.0011698984549089809 0.07761415748811447 0.013640543653369842 0.0028896084741953285 0.01771612477276575 1.0813664621119338e-07 6.966027103916661 0.541941328070561 (ac)AQISSNSGFK(ub)ECPSSHPEPTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQISSNSGFKECPSSHPEPTR 21 1 O00443;A0A0C4DGF9;O00443-2;E9PPP3 O00443 PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1 20173400.0 4209700.0 4957700.0 11006000.0 True False 6386422.670294184 4072959.700313103 8830659.275898835 1.0 0.6377529190571858 1.3827239022205304 22.606576606754313 -6.774451832080887 1.5571562478567165 0.7934136349992831 1.387666145404847 0.7474067660477576 0.15287246480818262 0.2592783967806867 1.2412412314253722 0.07735226612852776 0.18340838755592995 1.6809243479211563e-07 6.774451832080887 0.5942525104055638 (ac)AQISSNSGFK(ub)ECPSSHPEPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQISSNSGFKECPSSHPEPTR 21 1 O00443;A0A0C4DGF9;O00443-2;E9PPP3 O00443 PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1 7617300.0 2801300.0 2476400.0 2339600.0 True False 3837016.312286029 2366984.4596403027 1787034.6655744973 1.0 0.6168815212125313 0.465735488236643 21.87155346759929 -13.999999999998842 0.12847024570443946 2.8204748249077776 0.24989533763938976 0.999652595472424 0.0041911388886015175 11.939360304901236 0.1113085363334869 5.496217559912372 0.19185117883158234 1.0000000000026668e-14 13.999999999998842 -2.570579487268388 (ac)AQISSNSGFK(ub)ECPSSHPEPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQISSNSGFKECPSSHPEPTR 21 1 O00443;A0A0C4DGF9;O00443-2;E9PPP3 O00443 PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1 7809700.0 1951400.0 2081000.0 3777300.0 True False 1622675.561677763 2069789.2399538388 4567115.965738093 1.0 1.2755410193112067 2.8145589134379576 20.629943145089268 -6.937368398770028 0.6836043808471575 0.9816878417423586 3.199313402378275 0.997798540660292 0.03746115420993264 0.08898790677491819 0.0602315514958834 0.03577585605841205 0.13406804865553254 1.1551319632489602e-07 6.937368398770028 2.2176255606359168 up (ac)AQQAADK(ub)YLYVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQQAADKYLYVDK 13 1 P35579;Q5BKV1;B1AH99 P35579 MYH9 Myosin-9 1 10171400.0 2258600.0 3533600.0 4379200.0 True False 2961046.4723135117 3006400.6538649164 3926082.3922526073 1.0 1.0153169435115177 1.3259104269258895 21.497675702477302 -6.917157650248834 0.8455460041643047 0.9924200737641421 1.3728611837970741 0.9933541100585508 0.012241038408242096 0.09987313019191335 0.11449572458029154 0.01039113712830789 0.030328391414475447 1.2101587624109372e-07 6.917157650248834 0.380441110032932 (ac)AQQAADK(ub)YLYVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQQAADKYLYVDK 13 1 P35579;Q5BKV1;B1AH99 P35579 MYH9 Myosin-9 1 10732300.0 4113800.0 3897600.0 2720900.0 True False 3983209.6707802704 5453932.005715485 2008214.664749675 1.0 1.3692304589748385 0.5041699610947887 21.92549999254458 -6.790730356685075 1.493464711381269 1.20616553158135 0.4947898008344302 0.8036725291488298 0.15703850207786407 0.2342612011163748 1.032217408668821 0.08276324455069427 0.19366215039567142 1.61908497774021e-07 6.790730356685075 -0.7113757307469197 (ac)AQQAADK(ub)YLYVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQQAADKYLYVDK 13 1 P35579;Q5BKV1;B1AH99 P35579 MYH9 Myosin-9 1 25055000.0 9046800.0 9451000.0 6557200.0 True False 13724657.009672299 7764395.208999955 5261166.545877139 1.0 0.5657259925350473 0.38333683254666334 23.71026675977149 -13.999999999999998 0.11882448842024126 3.071744367518299 0.0875679909648319 0.9996987289979734 0.00448955537249714 11.968425972583505 0.10593407248541493 5.864637454887473 0.26244726368023785 1.0000000000000041e-14 13.999999999999998 -2.9841763765534672 (ac)AQQAADK(ub)YLYVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQQAADKYLYVDK 13 1 P35579;Q5BKV1;B1AH99 P35579 MYH9 Myosin-9 1 8769300.0 2258600.0 3389600.0 3121100.0 True False 3093665.456369982 3239836.264091738 2383960.4610722177 1.0 1.047248420937301 0.7705941365326192 21.560885764000194 -6.862910762389466 1.1708528463709424 1.0258637461136224 0.7564272591990755 0.9570863838749529 0.025030475997122624 0.14383835251303695 0.37304111741958546 0.016652203087248837 0.039009948069903405 1.3711634800422845e-07 6.862910762389466 -0.2694364869145469 (ac)AQQAADK(ub)YLYVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQQAADKYLYVDK 13 1 P35579;Q5BKV1;B1AH99 P35579 MYH9 Myosin-9 1 11784600.0 4113800.0 6077200.0 1593600.0 True False 3420806.972240429 6044460.917370249 1926814.39202611 1.0 1.766969304734397 0.5632631153005863 21.705905267978856 -6.734559355267838 1.706500782025393 1.4591941911901232 0.5633463729221443 0.5803237437781452 0.3223166785062802 0.3277520567242848 1.871823720989582 0.1495509197937423 0.36921531443971234 1.8426406370422015e-07 6.734559355267838 -0.8958478182679789 (ac)AQQAADK(ub)YLYVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQQAADKYLYVDK 13 1 P35579;Q5BKV1;B1AH99 P35579 MYH9 Myosin-9 1 22419200.0 9046800.0 9601000.0 3771400.0 True False 11711260.939088583 9066695.910042716 3085043.8978318437 1.0 0.7741861407750618 0.2634254256546293 23.48139308186394 -6.957569290213187 0.4684368213539145 1.013697563824333 0.0030303995720861038 0.9996691477167422 0.005604396770036727 0.08058114645721656 0.02442838515191849 0.007041533877308568 0.04216078274608889 1.1026322985674952e-07 6.957569290213187 -1.010667164252247 down (ac)ASCASIDIEDATQHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASCASIDIEDATQHLR 16 0 Q6P2E9 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 0 6151970.0 844870.0 2641900.0 2665200.0 False True 1107632.7517327175 2247738.8180455426 2389430.6704036463 1.0 2.0293177630666013 2.1572408965568752 20.079048188004226 -10.82924960184805 0.39404976183781415 1.0498450740814417e-09 2.1689204527220025 0.9994360425793192 0.012301734401486126 2.4927798326699735 0.19153471100373318 2.3655056975857938 0.03317947852131813 1.4816662830776195e-11 10.82924960184805 2.1689204516721574 (ac)ASCASIDIEDATQHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASCASIDIEDATQHLR 16 0 Q6P2E9 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 0 4629070.0 844870.0 1626200.0 2158000.0 False True 1157241.2707532567 1554349.1068757344 1648324.8454050971 1.0 1.3431504269321446 1.4243571215984983 20.142258249527117 -12.456590879019608 0.22668372247192772 1.992824894385685e-08 1.468000896395296 0.9994084751385983 0.00447306849371884 6.499315134024249 0.1409077040397519 3.0122776827823157 0.042970663493387184 3.494693731473975e-13 12.456590879019608 1.468000876467047 (ac)ASEDIAK(ub)LAETLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASEDIAKLAETLAK 14 1 P46060;B0QYT5;B0QYT4;B0QYT6 P46060 RANGAP1 Ran GTPase-activating protein 1 1 16072600.0 3878800.0 6435600.0 5758200.0 True False 5021183.062578684 6077453.202652935 4710266.684121373 1.0 1.2103628023336381 0.9380790593407212 22.259595893146926 -6.700415832795343 1.8295995199385204 1.1305740523702779 0.9388879068379801 0.4194904572571123 0.08878992983760944 0.39463853499856316 2.5686058841296875 0.038713716552865186 0.09950250686228936 1.9933527847896133e-07 6.700415832795343 -0.1916861455322978 (ac)ASEELQK(ub)DLEEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASEELQKDLEEVK 13 1 Q9HB71;B2ZWH1;Q9HB71-2 Q9HB71 CACYBP Calcyclin-binding protein 1 11534700.0 3845400.0 3975700.0 3713600.0 True False 4977946.10416625 3754448.8000788274 3037762.904753761 1.0 0.7542164421861807 0.6102442335025144 22.24711917978113 -12.87539349215941 0.06505575783102027 2.3240813246974668 2.364592980495764e-10 0.9999552122648229 0.0010768963808233506 8.331814538896658 0.05727927239779787 1.9910588373726832 0.5037278413214039 1.3323137433579186e-13 12.87539349215941 -2.3240813244610075 (ac)ASFVTEVLAHSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASFVTEVLAHSGR 13 0 O43264;O43264-2;F5H3C1 O43264 ZW10 Centromere/kinetochore protein zw10 homolog 0 1376610.0 0.0 796600.0 580010.0 False True 0.0 677750.3851224798 519996.1290487839 0.0 (ac)ASFVTEVLAHSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASFVTEVLAHSGR 13 0 O43264;O43264-2;F5H3C1 O43264 ZW10 Centromere/kinetochore protein zw10 homolog 0 1693010.0 0.0 548110.0 1144900.0 False True 0.0 523892.68784261367 874498.1999556526 0.0 (ac)ASGADSK(ub)GDDLSTAILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASGADSKGDDLSTAILK 17 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 1561641200.0 708910000.0 606564200.0 246167000.0 True False 929387875.0942056 516067185.72873354 220696000.2406031 1.0 0.5552764346924833 0.23746382555101944 29.791705582497606 -8.109656370880789 0.269194155289349 1.1657977812592732 3.631116093954653e-21 0.9993985449198344 0.007669765464587143 0.09062123676708969 0.05510041444212197 0.07553993575234026 0.09720601521650699 7.768615537892484e-09 8.109656370880789 -1.1657977812592732 down (ac)ASGADSK(ub)GDDLSTAILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASGADSKGDDLSTAILK 17 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 1969170000.0 819420000.0 719280000.0 430470000.0 True False 793407960.6278315 1006492254.9956466 317716993.1768136 1.0 1.2685683846670752 0.4004459356891265 29.56348763187914 -6.823650193779277 1.356280528487972 1.1442432290025697 0.38001167537643205 0.8925125858388068 0.11897589689491916 0.18878545791014578 0.6813898786903737 0.0689205792296752 0.15869582047213218 1.50089325613539e-07 6.823650193779277 -0.7642315536261377 down (ac)ASGADSK(ub)GDDLSTAILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASGADSKGDDLSTAILK 17 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 3470480000.0 1758800000.0 1113500000.0 598180000.0 True False 2668228185.503343 914787225.1847906 479949460.8083923 1.0 0.34284445016917553 0.17987571805739436 31.313234904323256 -13.99999999999971 0.19582489092673103 4.596549929897773 0.06957345866714895 0.9994872460527936 0.00802726361550833 12.451429725673721 0.14032936952609146 17.123646111114635 0.10709580464063465 1.0000000000006667e-14 13.99999999999971 -4.526976471230624 (ac)ASGADSK(ub)GDDLSTAILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASGADSKGDDLSTAILK 17 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 1579020000.0 708910000.0 555740000.0 314370000.0 True False 971013184.57241 531185569.21357775 240122280.65338278 1.0 0.5470425918547004 0.24729044308406758 29.854915644020497 -8.30255734277039 0.24782979768066193 1.213723157758569 3.8866366954401357e-23 0.9994644954182031 0.007159973119552589 0.09984632836688312 0.05742354111349617 0.1047751448338694 0.10656029793993695 4.98244665091545e-09 8.30255734277039 -1.213723157758569 down (ac)ASGADSK(ub)GDDLSTAILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASGADSKGDDLSTAILK 17 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 2215055900.0 819420000.0 1107200000.0 288435900.0 True False 681384036.4609984 1101235293.8380082 348746513.1130797 1.0 1.6161741909271183 0.5118207860055165 29.343892907313418 -6.755282137027911 1.630267267558264 1.359998775053494 0.5087050069357755 0.6714097093874234 0.2590180012255309 0.29091157876688883 1.522696577492949 0.12542832353081554 0.3028403207618764 1.7567819594006738e-07 6.755282137027911 -0.8512937681177186 (ac)ASGADSK(ub)GDDLSTAILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASGADSKGDDLSTAILK 17 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 3874541000.0 1758800000.0 1516951000.0 598790000.0 True False 2276801271.131119 1432531343.3429008 489816364.1042401 1.0 0.629185937967795 0.21513356054167104 31.084361226415705 -7.494322596808411 0.37089622473543105 1.0486482079367785 1.4102956669479413e-12 0.9992442153498416 0.008813301708557564 0.11997239292452698 0.04223716192413161 0.01945201970744759 0.0654830419553285 3.203888570812377e-08 7.494322596808411 -1.0486482079353683 down (ac)ASGADSK(ub)GDDLSTAILK(ub)QK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASGADSKGDDLSTAILKQK 19 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 2 29288900.0 9386400.0 12338000.0 7564500.0 True False 12305661.29802691 10497218.493147323 6781798.10380775 1.0 0.8530397707948005 0.5511120401871571 23.5528188535597 -6.959515739550912 0.4422063399295397 1.01055064194008 0.38178622861611655 0.9997518126905041 0.002943817692344531 0.07987456625324262 0.021773979504719806 0.0039919132549661816 0.025006397084766475 1.0977015070331728e-07 6.959515739550912 -0.6287644133239635 (ac)ASGADSK(ub)GDDLSTAILK(ub)QK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASGADSKGDDLSTAILKQK 19 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 2 50604000.0 16816000.0 23262000.0 10526000.0 True False 16282185.284613034 32550637.90972746 7768924.8267687345 1.0 1.9991565837595777 0.4771426372423431 23.95679100556617 -6.729593515182747 1.7245502239651052 1.601546454465009 0.4780852229195229 0.5574798079954855 0.42003437311179204 0.3369867373930784 1.963232264028539 0.19302163617789958 0.4792202709703979 1.8638308025683466e-07 6.729593515182747 -1.1234612315454862 (ac)ASGADSK(ub)GDDLSTAILK(ub)QK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASGADSKGDDLSTAILKQK 19 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 2 80844000.0 33029000.0 33158000.0 14657000.0 True False 50107407.74334195 27240695.835363567 11760037.525608674 1.0 0.5436460807331065 0.23469658589894415 25.57852056752359 -8.24157719331238 0.26100954065695997 1.1896822782329597 4.257333176687923e-20 0.999386024000711 0.007789371173110864 0.09222701823045044 0.05862955956510733 0.0932337922768881 0.10224736732305434 5.733539471667795e-09 8.24157719331238 -1.1896822782329597 down (ac)ASGADSK(ub)GDDLSTAILK(ub)QK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASGADSKGDDLSTAILKQK 19 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 2 38592400.0 9386400.0 17165000.0 12041000.0 True False 12856805.73792227 16406593.54293563 9197163.79217924 1.0 1.2761018465529856 0.7153537184630085 23.61602891508259 -6.772802547810417 1.5635706362567845 1.157794869396287 0.711847752943641 0.7412312451606766 0.11645682088105754 0.26191504889737977 1.2640336426294048 0.05869282424778826 0.13936608761900438 1.6873199918491873e-07 6.772802547810417 -0.44594711645264595 (ac)ASGADSK(ub)GDDLSTAILK(ub)QK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASGADSKGDDLSTAILKQK 19 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 2 46265500.0 16816000.0 21237000.0 8212500.0 True False 13983249.075111846 21122592.06578556 9929695.779690277 1.0 1.5105639577986714 0.7101136314137245 23.737196281000447 -6.7344016262439785 1.7072855168723498 1.3057368970898775 0.7102008372260854 0.5795338814715292 0.21456418091977875 0.32803118505392365 1.8751133802596 0.09951667770445295 0.2457130713290068 1.8433099770985443e-07 6.7344016262439785 -0.5955360598637921 (ac)ASGADSK(ub)GDDLSTAILK(ub)QK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASGADSKGDDLSTAILKQK 19 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 2 106022000.0 33029000.0 54584000.0 18409000.0 True False 42756691.5989252 51546352.41680769 15058750.892291063 1.0 1.2055739227986348 0.3521963540478797 25.34964688961604 -6.843090316264591 1.2679718707123229 1.1093541207739246 0.3223673377629344 0.9296393758020268 0.0964599196042622 0.1652179897056322 0.5146479709799153 0.05961978100837215 0.13748722719681514 1.435190938740081e-07 6.843090316264591 -0.7869867830109902 down (ac)ASGADSKGDDLSTAILK(ub)QK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASGADSKGDDLSTAILKQK 19 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 431469500.0 163430500.0 181220000.0 86819000.0 True False 214258968.16321328 154182682.3900275 77835802.70665398 1.0 0.7196090026559716 0.36327908873042836 27.67478035108574 -6.967865654984974 0.30488658766176413 1.058318189631144 0.013326357323717494 0.9999606221918055 0.0016350223942461271 0.07700150038449319 0.011495962658180411 0.005773035821807172 0.031796116094252334 1.0767982597810508e-07 6.967865654984974 -1.0449918323074265 down (ac)ASGADSKGDDLSTAILK(ub)QK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASGADSKGDDLSTAILKQK 19 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 1053896200.0 551170000.0 338616200.0 164110000.0 True False 533673410.04520494 473827414.52015543 121124667.80553105 1.0 0.8878602636020778 0.2269640299209795 28.991381890808178 -6.936214752958437 0.6938810399572855 1.0081226624418602 0.06697790517072075 0.9976249354667386 0.01662180195148697 0.08953662098522258 0.06279546859917384 0.01574891016664154 0.057893769601462454 1.1582044975093071e-07 6.936214752958437 -0.9411447572711394 down (ac)ASGADSKGDDLSTAILK(ub)QK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASGADSKGDDLSTAILKQK 19 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 3306253000.0 1461411000.0 1085300000.0 759542000.0 True False 2217067330.455214 891619735.5123956 609418190.7809157 1.0 0.4021617761736293 0.27487581563695157 31.04600543828207 -13.999999999999998 0.21740819093277478 4.567165628401021 0.20507605220042815 0.999495432497451 0.0071009894563211365 12.930423130250295 0.14773216558417743 19.775746986792452 0.07166721484849803 1.0000000000000041e-14 13.999999999999998 -4.362089576200593 (ac)ASGADSKGDDLSTAILK(ub)QK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASGADSKGDDLSTAILKQK 19 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 548216500.0 163430500.0 287106000.0 97680000.0 True False 223855172.3931969 274420707.58742076 74609995.78274797 1.0 1.2258850427874257 0.33329583134088625 27.73799041260863 -6.83963228361504 1.2841736507106447 1.1201669218507273 0.3041628024855539 0.9238155813796481 0.10458813181290574 0.16922249617524324 0.5422575043508001 0.06386841166488734 0.14712034058512127 1.4466641403567568e-07 6.83963228361504 -0.8160041193651735 down (ac)ASGADSKGDDLSTAILK(ub)QK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASGADSKGDDLSTAILKQK 19 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 1165201200.0 551170000.0 509421200.0 104610000.0 True False 458322275.9710631 506676846.8834083 126483467.33800909 1.0 1.1055034272770066 0.27597058657038703 28.771787166242454 -6.874979459435856 1.107471776380592 1.0618981409845165 0.22257298236444276 0.9694025505986836 0.06449392103223897 0.13216747909290003 0.29998370037640143 0.04504591362061079 0.10766698138945686 1.3335845044136532e-07 6.874979459435856 -0.8393251586200737 down (ac)ASGADSKGDDLSTAILK(ub)QK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASGADSKGDDLSTAILKQK 19 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 3845850000.0 1461411000.0 1746049000.0 638390000.0 True False 1891825348.2175364 1648879838.2495732 522209570.43455243 1.0 0.8715814278538636 0.2760347676526136 30.81713176037452 -6.941497550028729 0.6454873225167136 1.0065503897758548 0.1081065821638543 0.9983534691328024 0.012798120305981283 0.08709020165020237 0.05154922046429355 0.01260412848016978 0.050928901470390246 1.1442013345443828e-07 6.941497550028729 -0.8984438076120005 down (ac)ASGAGGVGGGGGGK(ub)IR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASGAGGVGGGGGGKIR 16 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 8947600.0 2424100.0 3113100.0 3410400.0 True False 2347148.272385257 4356177.064602033 2517113.9301930577 1.0 1.8559445587027736 1.072413685921544 21.162477550971463 -10.244240167922072 4.364888253354207 0.9997671722939996 1.4641791223207063 0.3187770195285097 0.319875139369039 0.0007265227013561112 0.00012579321293593467 0.309871672200802 0.10323925729925543 5.698490545698674e-11 10.244240167922072 0.46441195002670677 (ac)ASGAGGVGGGGGGK(ub)IR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASGAGGVGGGGGGKIR 16 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 2331400.0 772770.0 980000.0 578630.0 True False 1058483.9523240195 936700.3595733725 441969.5112589215 1.0 0.8849452630025637 0.4175495625498414 20.013567966134904 -6.944519637298187 0.6160871615748141 1.0051321816863645 0.2727667159442237 0.998697917547808 0.009088557914863734 0.08576400573276473 0.04566605625299643 0.009185832427587966 0.039498268243497635 1.1362669184357101e-07 6.944519637298187 -0.7323654657421408 down (ac)ASGAGGVGGGGGGK(ub)IR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASGAGGVGGGGGGKIR 16 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 9402200.0 2424100.0 5904500.0 1073600.0 True False 2015746.5558384066 5872691.286548507 1298084.7962344585 1.0 2.913407575738552 0.64397222581117 20.94288282640574 -6.683185625938098 1.890684923634435 2.2071591510237485 0.6524057605986904 0.33873083394208114 0.8103887980110468 0.43147346393021985 2.9847534423942026 0.34359729788814525 0.9024947393850814 2.0740268484228423e-07 6.683185625938098 -1.5547533904250581 (ac)ASGVAVSDGVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASGVAVSDGVIK 12 0 P23528;E9PP50;E9PS23 P23528 CFL1 Cofilin-1 0 43010500.0 5957500.0 19124000.0 17929000.0 False True 7810340.192512071 16270773.744768132 16073879.067112029 1.0 2.083234960798154 2.058025472760121 22.896953958070593 -10.419011826245544 5.997575024821348 0.9996491517336701 2.0706302167791377 0.9995843479697216 0.010291730394997409 4.829666238251332e-05 4.678533675493992e-06 0.009967954562249482 0.003321641701956593 3.8105544675574256e-11 10.419011826245544 1.0709810650454676 (ac)ASGVAVSDGVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASGVAVSDGVIK 12 0 P23528;E9PP50;E9PS23 P23528 CFL1 Cofilin-1 0 31502700.0 9838200.0 3559500.0 18105000.0 False True 9525891.726158405 4980826.912547279 13362757.361642433 1.0 0.5228725095488718 1.4027828308134 23.183422720060324 -6.7594248558383265 1.6144053566736276 0.7226587413249143 1.4059319311903802 0.6886903144711005 0.20066665432343686 0.28389077938506063 1.4581150577274016 0.09807295988633614 0.2358404151477349 1.7401037548826075e-07 6.7594248558383265 0.6832731898654659 (ac)ASGVAVSDGVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASGVAVSDGVIK 12 0 P23528;E9PP50;E9PS23 P23528 CFL1 Cofilin-1 0 37433500.0 5957500.0 16543000.0 14933000.0 False True 8160148.745383949 15812075.559614595 11406132.954788838 1.0 1.937719035888801 1.3977849314623196 22.960164019593485 -10.327662922842567 6.884762726919662 0.9999843064220855 1.6677519836755594 0.6709801588382291 0.22042717509524792 5.310061167424122e-05 5.18547618016826e-06 0.21343269670161152 0.07114256484962014 4.702589579419214e-11 10.327662922842567 0.667767677253474 (ac)ASGVAVSDGVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASGVAVSDGVIK 12 0 P23528;E9PP50;E9PS23 P23528 CFL1 Cofilin-1 0 15907700.0 9838200.0 2761100.0 3308400.0 False True 8180899.206158727 2746225.4062645584 4000171.1436867407 1.0 0.3356874760414052 0.48896472660063334 22.9638279954946 -10.227127044752846 8.232532245995738 1.0000002549381912 0.4123261013237242 0.9514563173430565 0.06257517550780609 2.928195183487566e-07 2.7526340813671357e-08 0.06058817933769367 0.0201960510523116 5.927519006991499e-11 10.227127044752846 -0.587674153614467 (ac)ASGVAVSDGVIK(ub)VFNDMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASGVAVSDGVIKVFNDMK 18 1 P23528;E9PP50;E9PS23 P23528 CFL1 Cofilin-1 1 9651200.0 4811500.0 3408600.0 1431100.0 True False 4000975.4355911408 3390237.195245878 1730336.3933412177 1.0 0.8473526643247119 0.432478634572162 21.931920340457168 -6.953647444130803 0.5172531999723804 1.007202435537876 0.2542010879755016 0.9994573093630762 0.005586126488786028 0.08205333273845118 0.03015044656599758 0.006356399844759457 0.03425996564261628 1.112634586273241e-07 6.953647444130803 -0.7530013475623742 down (ac)ASK(ub)EMFEDTVEER ddPTM_RPMI8226_Bortezomib_1h_R1 2 ASKEMFEDTVEER 13 1 Q16576;E9PC52 Q16576 RBBP7 Histone-binding protein RBBP7 1 96936000.0 36177800.0 35188000.0 25570200.0 True False 47429446.14631354 29938087.561749723 22924440.99067815 1.0 0.6312130963830929 0.4833377332714216 25.49927968576766 -13.99999999999696 0.12598913333905265 2.752797662391894 0.265299279993412 0.999664133032449 0.0039816190965186425 11.94481029676494 0.10996486158459837 5.205060077922305 0.19366732039591836 1.0000000000069983e-14 13.99999999999696 -2.4874983823984818 (ac)ASK(ub)EMFEDTVEER ddPTM_RPMI8226_Bortezomib_2h_R1 2 ASKEMFEDTVEER 13 1 Q16576;E9PC52 Q16576 RBBP7 Histone-binding protein RBBP7 1 157272900.0 58169000.0 43792600.0 55311300.0 True False 56322456.9351008 61279213.55539203 40823611.22656789 1.0 1.0880067541443157 0.7248194316808318 25.74720693374733 -6.842707511206156 1.2699576855773471 1.0468109214212242 0.7122342886177723 0.9289768152323923 0.041226457600347745 0.16566407112733297 0.5178592103034455 0.02544443982558744 0.05866205571171838 1.4364565328850813e-07 6.842707511206156 -0.33457663280345196 (ac)ASK(ub)EMFEDTVEER ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ASKEMFEDTVEER 13 1 Q16576;E9PC52 Q16576 RBBP7 Histone-binding protein RBBP7 1 110112900.0 36177800.0 41832300.0 32102800.0 True False 49553710.32828386 39984010.66508284 24520779.817919735 1.0 0.8068822778394678 0.49483236785851664 25.562489747290552 -6.96399167336527 0.3749606032422151 1.02268713955271 0.2680804130742183 0.9998908188561324 0.002174741125875808 0.07830487638796994 0.016077123770609495 0.004084651600478325 0.026433581607286687 1.0864464536216534e-07 6.96399167336527 -0.7546067264784917 down (ac)ASK(ub)EMFEDTVEER ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ASKEMFEDTVEER 13 1 Q16576;E9PC52 Q16576 RBBP7 Histone-binding protein RBBP7 1 124751900.0 58169000.0 16122600.0 50460300.0 True False 48370100.82363109 16035744.353714474 61011315.42793366 1.0 0.3315218302352649 1.2613435653234515 25.527612209181605 -6.713779703327739 1.7818714221918612 0.5906288876904832 1.2593986605394945 0.48298305196228486 0.28153247653742813 0.3675219982191451 2.2769637696340013 0.1256292868834422 0.31768652381149015 1.932948560082186e-07 6.713779703327739 0.6687697728490113 (ac)ASK(ub)EMFEDTVEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASKEMFEDTVEER 13 1 Q16576;E9PC52 Q16576 RBBP7 Histone-binding protein RBBP7 1 94446400.0 19397000.0 19259400.0 55790000.0 True False 25109798.87203225 18187597.459626753 45636792.453741014 1.0 0.7243227057419576 1.8174893668531968 24.581747136967355 -6.839874932298064 1.2829157289409374 0.8533402929840194 1.8533687398131513 0.9242473801258791 0.127761526732587 0.16894576829494215 0.5401855346647272 0.0780892399407705 0.17990247018845343 1.4458560870256852e-07 6.839874932298064 1.0000284468291318 (ac)ASLLK(ub)VDQEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASLLKVDQEVK 11 1 P61289;P61289-2;K7ESG5;K9J957;K7ENH2;A0A087WTV2;B7Z8D3;K7EJF8 P61289 PSME3 Proteasome activator complex subunit 3 1 21620000.0 6411500.0 8728800.0 6479700.0 True False 8405538.58905432 7426497.064595915 5809242.801671358 1.0 0.8835242365393086 0.6911208294535873 23.002908833147693 -6.963605095741044 0.38123733053233927 1.0130337674770085 0.5547940638983339 0.999881435389152 0.0013868103556277846 0.0784375749973984 0.016549128025779812 0.00250084637969354 0.016248334035513772 1.08741396043304e-07 6.963605095741044 -0.4582397035786746 (ac)ASLLK(ub)VDQEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASLLKVDQEVK 11 1 P61289;P61289-2;K7ESG5;K9J957;K7ENH2;A0A087WTV2;B7Z8D3;K7EJF8 P61289 PSME3 Proteasome activator complex subunit 3 1 49201000.0 18958000.0 18281000.0 11962000.0 True False 18356188.66708454 25580698.634155616 8828793.347692171 1.0 1.393573529783213 0.4809709416161946 24.129763204341327 -6.789503858766399 1.4982681830576772 1.220113445530054 0.47139274551726706 0.7997106589916183 0.16726249979754276 0.23610184513374136 1.047042879663032 0.08787279281884258 0.2058104446353305 1.6236639239403396e-07 6.789503858766399 -0.7487207000127869 down (ac)ASLLK(ub)VDQEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASLLKVDQEVK 11 1 P61289;P61289-2;K7ESG5;K9J957;K7ENH2;A0A087WTV2;B7Z8D3;K7EJF8 P61289 PSME3 Proteasome activator complex subunit 3 1 21360700.0 6411500.0 8813500.0 6135700.0 True False 8782004.814272624 8424090.42765297 4686574.028708089 1.0 0.9592445695272261 0.5336565087155738 23.066118894670584 -6.925500027599826 0.7828557522581032 1.0076639455726715 0.4555227437637045 0.9955772648949984 0.014024797522711678 0.0950429542311928 0.08962966688232006 0.012450309455731305 0.0395040410924927 1.1871346256000658e-07 6.925500027599826 -0.552141201808967 (ac)ASLLK(ub)VDQEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASLLKVDQEVK 11 1 P61289;P61289-2;K7ESG5;K9J957;K7ENH2;A0A087WTV2;B7Z8D3;K7EJF8 P61289 PSME3 Proteasome activator complex subunit 3 1 43603600.0 18958000.0 19470000.0 5175600.0 True False 15764416.981801271 19365111.24550758 6257794.030729377 1.0 1.2284064337972673 0.3969568958974815 23.910168479775603 -6.833476206732379 1.3123638106993163 1.121780694962235 0.372961020440771 0.9126398993602416 0.10366600124692527 0.17656011059656604 0.5934876872675083 0.06199865538681373 0.1426768208261294 1.4673164731402527e-07 6.833476206732379 -0.7488196745214641 down (ac)ASLSLAPVNIFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASLSLAPVNIFK 12 0 P78371;F5GWF6;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 16191400.0 6053400.0 10138000.0 0.0 False True 9183450.362818938 8328794.691444463 0.0 1.0 0.906935232662146 0.0 23.130604867417418 -7.109072849231796 0.9801545896668916 0.9992702572233078 1.925278082281186e-18 0.9895593478462925 0.046090303057442376 0.08507266828032214 0.15525783161538995 0.0381169876083134 0.06725076998293729 7.779060529240378e-08 7.109072849231796 -0.9992702572233078 down (ac)ASLSLAPVNIFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASLSLAPVNIFK 12 0 P78371;F5GWF6;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 17550000.0 6053400.0 5266400.0 6230200.0 False True 7836245.630353152 4973320.210462335 5096367.527250356 1.0 0.634655987709028 0.6503583179564881 22.901731189509867 -10.02117275164429 7.325233678657258 1.0000000241617686 0.6425071528400116 0.9985551353495358 0.00641044947982484 2.5288687987889292e-09 3.409075067277898e-10 0.0062068913892248095 0.00206896367308877 9.524172405538189e-11 10.02117275164429 -0.357492871321757 (ac)ASLSLAPVNIFK(ub)AGADEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASLSLAPVNIFKAGADEER 19 1 P78371;F5GWF6;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 27176700.0 6257600.0 13422000.0 7497100.0 True False 8203774.198684597 11419489.918546218 6721372.009261292 1.0 1.3919800377218126 0.8193024145324483 22.96785635283854 -6.722465055027989 1.7501807719676599 1.2378532675484322 0.8200568416638523 0.5241131280040976 0.1649004431475409 0.35061640271758004 2.1001544590666166 0.07476837368471413 0.18717334069478603 1.894675960997128e-07 6.722465055027989 -0.4177964258845799 (ac)ASLSLAPVNIFK(ub)AGADEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASLSLAPVNIFKAGADEER 19 1 P78371;F5GWF6;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 89711000.0 27026000.0 35311000.0 27374000.0 True False 26168074.423284464 49410866.44443244 20203928.197602835 1.0 1.8882117822344024 0.7720831067197399 24.64130443184601 -6.694701542409663 1.849403156555619 1.5544002753648032 0.7756854836615097 0.3924671011795916 0.3753049010127249 0.4067447689692343 2.7006896345024014 0.16211455088517734 0.4197204793231802 2.019753910207274e-07 6.694701542409663 -0.7787147917032935 (ac)ASLSLAPVNIFK(ub)AGADEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASLSLAPVNIFKAGADEER 19 1 P78371;F5GWF6;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 137672000.0 48800000.0 39884000.0 48988000.0 True False 74033167.7578821 32766388.584885683 39305500.32779687 1.0 0.4425906600679955 0.530917445763519 26.141668424673494 -10.776284842369186 7.1132069020863655 1.0131520461836065 0.48675405291575724 0.9782702898139576 0.03605925926236543 0.007371621006197723 0.000231842109160689 0.03422062980761556 0.011638075883309743 1.6738446850657452e-11 10.776284842369186 -0.5263979932678493 (ac)ASLSLAPVNIFK(ub)AGADEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASLSLAPVNIFKAGADEER 19 1 P78371;F5GWF6;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 52929600.0 6257600.0 27227000.0 19445000.0 True False 8571203.825281503 26024021.11235124 14852491.482345741 1.0 3.0362154071743284 1.7328361085682085 23.031066414361433 -10.084318557564425 4.735020244257963 0.9999610559841255 2.384525757833573 0.6007225644052683 0.5321023707534381 184907079.60642433 16.4146341484208 128829.68187801073 0.18215279455961458 8.235338264956533e-11 10.084318557564425 1.3845647018494471 (ac)ASLSLAPVNIFK(ub)AGADEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASLSLAPVNIFKAGADEER 19 1 P78371;F5GWF6;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 73789000.0 27026000.0 33540000.0 13223000.0 True False 22473316.45480331 33359313.362831242 15987868.163755802 1.0 1.484396547786841 0.7114156113054979 24.421709707280286 -6.737298225157484 1.696757346175787 1.2891131855363964 0.71123853051249 0.5926965135973334 0.203539228589662 0.3227181937869514 1.8232534963941744 0.09494344357057381 0.23366200468717654 1.8310566244829543e-07 6.737298225157484 -0.5778746550239064 (ac)ASLSLAPVNIFK(ub)AGADEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASLSLAPVNIFKAGADEER 19 1 P78371;F5GWF6;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 140150000.0 48800000.0 43246000.0 48104000.0 True False 63172561.99181175 40839322.083710775 39349565.58872118 1.0 0.646472468363785 0.6228901337549292 25.912794746765943 -13.999999999999998 0.3847017845761547 6.404091384846346 0.6209866175249455 0.9998149870286643 0.002346081044265821 24.6400549921809 0.20274650942356673 110.49051351013732 0.006303099308509143 1.0000000000000041e-14 13.999999999999998 -5.783104767321401 (ac)ASMGTLAFDEYGRPFLIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASMGTLAFDEYGRPFLIIK 19 1 P48643;E7ENZ3;D6RIZ7 P48643 CCT5 T-complex protein 1 subunit epsilon 0 6752500.0 3106000.0 1144700.0 2501800.0 False True 3007401.7301384397 1601784.6795316406 1846503.5276087802 1.0 0.5326141378052295 0.6139863221811008 21.52008616599129 -10.789536899739826 7.143464384370218 1.0133871074076244 0.5733002299931651 0.9734489566454165 0.03322005516275974 0.006967159815361087 0.0002052684846199316 0.03164054193370779 0.010721726700455016 1.623540400851485e-11 10.789536899739826 -0.4400868774144593 (ac)ASMGTLAFDEYGRPFLIIK(ub)DQDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASMGTLAFDEYGRPFLIIKDQDR 23 2 P48643;E7ENZ3;D6RIZ7 P48643 CCT5 T-complex protein 1 subunit epsilon 1 13077500.0 5650500.0 3042200.0 4384800.0 True False 5471127.970427329 4256966.324863418 3236289.338819642 1.0 0.778078368459534 0.5915214113638925 22.38340687027254 -6.973129789849901 0.1673133026346513 1.1709135530517478 0.19370291479493884 0.9999976353540445 0.00025668989630154654 0.07529962391326196 0.005204015987791155 0.008059600846415063 0.021811889076074877 1.0638250442862617e-07 6.973129789849901 -0.977210638256809 (ac)ASMGTLAFDEYGRPFLIIK(ub)DQDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASMGTLAFDEYGRPFLIIKDQDR 23 2 P48643;E7ENZ3;D6RIZ7 P48643 CCT5 T-complex protein 1 subunit epsilon 1 115427000.0 67438000.0 32130000.0 15859000.0 True False 102308376.37819795 26396150.4671642 12724461.698753363 1.0 0.25800576063866903 0.12437360604488062 26.608349027980466 -13.999999999999998 0.2411088021026611 5.93781123796417 0.06590706596871909 0.9995268133863429 0.008378328615890112 13.662838370996559 0.15540624490847704 32.50371600805982 0.06487509980567543 1.0000000000000041e-14 13.999999999999998 -5.8719041719954514 (ac)ASMGTLAFDEYGRPFLIIK(ub)DQDR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ASMGTLAFDEYGRPFLIIKDQDR 23 2 P48643;E7ENZ3;D6RIZ7 P48643 CCT5 T-complex protein 1 subunit epsilon 1 43268500.0 20123500.0 13907000.0 9238000.0 True False 16733581.87220583 13832080.23067664 11169623.088314015 1.0 0.8266060629644075 0.6674974415887942 23.996242955742282 -6.972153788236856 0.20016738822998 1.0945009715037295 0.39520876461756205 0.9999946660132611 0.0003135489019367534 0.07560979229963966 0.006464446660839935 0.00515862421839458 0.016884166382132748 1.0662184952073143e-07 6.972153788236856 -0.6992922068861674 (ac)ASMGTLAFDEYGRPFLIIK(ub)DQDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASMGTLAFDEYGRPFLIIKDQDR 23 2 P48643;E7ENZ3;D6RIZ7 P48643 CCT5 T-complex protein 1 subunit epsilon 1 96143300.0 67438000.0 19173000.0 9532300.0 True False 87299820.40171736 18106005.69557846 7797519.209657558 1.0 0.20740026282141444 0.08931884594695186 26.379475350072916 -13.999999999999998 0.2680982828358888 7.055588646115229 0.049395257251733576 0.9995792559024189 0.008294065375616992 14.790667346548233 0.16389352420436215 48.761066862905544 0.049512247842585 1.0000000000000041e-14 13.999999999999998 -7.006193388863496 (ac)ASNK(ub)TTLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASNKTTLQK 9 1 Q13185;C9JMM0;B8ZZ43 Q13185 CBX3 Chromobox protein homolog 3 1 11944100.0 4557200.0 4591300.0 2795600.0 True False 4412534.180485163 6424630.033313197 2063348.493797711 1.0 1.455995527859413 0.4676107672826783 22.073176023192513 -6.781245984301425 1.53075303074072 1.2577870674039906 0.4594406039349227 0.7718110704821718 0.19294329066915308 0.24867125875331103 1.1509537051151675 0.09926097586041047 0.23399728522322533 1.6548324012598466e-07 6.781245984301425 -0.7983464634690679 down (ac)ASNK(ub)TTLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASNKTTLQK 9 1 Q13185;C9JMM0;B8ZZ43 Q13185 CBX3 Chromobox protein homolog 3 1 5707600.0 2031100.0 2553400.0 1123100.0 True False 2782052.558413654 2440582.3450353537 857846.9109705585 1.0 0.8772596109496188 0.30835036109443914 21.407718244792566 -6.941509152312602 0.6453719382155184 1.0062566566158082 0.1478742196112046 0.9983549517080823 0.012220984749516384 0.08708487537423057 0.05152484825492146 0.012036913857366383 0.04864856592318102 1.144170767332691e-07 6.941509152312602 -0.8583824370046036 down (ac)ASNK(ub)TTLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASNKTTLQK 9 1 Q13185;C9JMM0;B8ZZ43 Q13185 CBX3 Chromobox protein homolog 3 1 13099000.0 4557200.0 7297400.0 1244400.0 True False 3789513.71819099 7258087.457779505 1504598.2865444843 1.0 1.9153084003728893 0.39704257549507915 21.85358129862679 -6.743446165975574 1.6738342597855893 1.5424085213215166 0.3954212393230168 0.6204257836798359 0.3845587268047852 0.31161097575859004 1.7154474129738433 0.1816495118978946 0.44411882218542953 1.8053185058905125e-07 6.743446165975574 -1.1469872819984999 (ac)ASNVTNK(ub)TDPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASNVTNKTDPR 11 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 79855000.0 27135000.0 32860000.0 19860000.0 True False 35574247.77571376 27957416.08727679 17805077.71057197 1.0 0.785889170827755 0.5005046859410293 25.084329915222717 -6.967146057792979 0.3190866048373443 1.0395046296337707 0.23769674105104616 0.9999507890362364 0.0014353307915053327 0.07724011544940268 0.012331055777014004 0.004341991383920435 0.02512343109290889 1.078583922131784e-07 6.967146057792979 -0.8018078885827244 (ac)ASNVTNK(ub)TDPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASNVTNKTDPR 11 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 110991000.0 32168000.0 41558000.0 37265000.0 True False 31146844.447872963 58152326.12210702 27504178.573963232 1.0 1.8670374849506874 0.8830486382013415 24.89258267240435 -6.674053940152714 1.9230852620421255 1.5514826349372275 0.8869524887939625 0.29713473077427843 0.36795733283938065 0.45184863956838994 3.2254004263994407 0.1538305696206032 0.4088240163073625 2.1180980473386823e-07 6.674053940152714 -0.664530146143265 (ac)ASNVTNK(ub)TDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASNVTNKTDPR 11 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 306190000.0 49487000.0 53993000.0 202710000.0 True False 75075396.98430966 44357527.30076548 162644279.64905068 1.0 0.5908397302252821 2.1664125157146015 26.161836862708988 -6.837740551971846 1.2928273995396797 0.7822333986903764 2.2159666793492043 0.9205067042622317 0.1882069558641776 0.17145032219587486 0.5576216284980637 0.11419280391647374 0.2629432639787257 1.4529793699278126e-07 6.837740551971846 1.4337332806588279 up (ac)ASNVTNK(ub)TDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASNVTNKTDPR 11 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 83667000.0 27135000.0 35385000.0 21147000.0 True False 37167542.79580245 33821573.69745281 16152514.13613604 1.0 0.9099760477378795 0.4345865483999722 25.14753997674561 -6.938594502642832 0.6725126380358555 1.0054879955271092 0.3115217297890455 0.9979739426239999 0.0111654913905675 0.08841374769585855 0.057573882718394684 0.010756333743564609 0.041175658457523995 1.1518753840358211e-07 6.938594502642832 -0.6939662657380636 down (ac)ASNVTNK(ub)TDPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASNVTNKTDPR 11 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 115056000.0 32168000.0 60766000.0 22122000.0 True False 26749117.284026973 60438641.496893376 26747607.919428762 1.0 2.259463026579342 0.9999435732931975 24.672987947838628 -6.6461740964578535 2.021927981290811 1.8197262363234157 1.005201350994008 0.17873015569480744 0.5380613945739872 0.5180129485171576 4.054608297644617 0.21613439870029422 0.5959850090510102 2.2585302074108908e-07 6.6461740964578535 -0.8145248853294076 (ac)ASNVTNK(ub)TDPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASNVTNKTDPR 11 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 206503000.0 49487000.0 54116000.0 102900000.0 True False 64061897.034606315 51104397.02821276 84173255.84316087 1.0 0.7977346815160048 1.3139363606059054 25.932963184801437 -6.800442308756692 1.4542976228140574 0.8884645958328461 1.321124770892898 0.8334034880106806 0.08668382326110266 0.22012599575226788 0.9191190432590709 0.04689223387374078 0.10901545725919629 1.5832798740478044e-07 6.800442308756692 0.43266017506005183 (ac)ASSDIQVK(ub)ELEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASSDIQVKELEK 12 1 P16949;P16949-2;A2A2D0 P16949 STMN1 Stathmin 1 12809100.0 2931200.0 6582800.0 3295100.0 True False 3842831.5857811794 5600671.89955343 2954154.6608311064 1.0 1.457433607102746 0.7687442436357979 21.87373832020254 -6.727627388557112 1.7318212626921445 1.2760027998997312 0.7693228816005416 0.5482798712703019 0.1923323978528566 0.34069329989217473 2.0006921462088125 0.08804802178741485 0.21907950913601687 1.8722878173997168e-07 6.727627388557112 -0.5066799182991896 (ac)ASSDIQVK(ub)ELEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASSDIQVKELEK 12 1 P16949;P16949-2;A2A2D0 P16949 STMN1 Stathmin 1 19891200.0 6444200.0 5883900.0 7563100.0 True False 6239632.398376739 8233371.954133144 5582097.221863449 1.0 1.3195283677729288 0.8946195649788039 22.57302960599812 -6.705505930086489 1.8111522701263687 1.1973374807165138 0.8957427430503664 0.44371219899269443 0.13474669430062333 0.3842124679305783 2.4538482664487717 0.059268521713578146 0.15140023915770165 1.9701263058868117e-07 6.705505930086489 -0.3015947376661474 (ac)ASSDIQVK(ub)ELEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASSDIQVKELEK 12 1 P16949;P16949-2;A2A2D0 P16949 STMN1 Stathmin 1 9824800.0 2931200.0 3799700.0 3093900.0 True False 4014943.8527015396 3631816.690072392 2363184.540870633 1.0 0.9045747146946146 0.5885971579105681 21.936948381725433 -6.949212811729812 0.5674188418851953 1.0039830960063605 0.47389409590296405 0.9991380592378598 0.005161736426539571 0.0838033672007408 0.03728231260167727 0.005484781589596341 0.026310722168701367 1.1240540332763872e-07 6.949212811729812 -0.5300890001033964 (ac)ASSDIQVK(ub)ELEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASSDIQVKELEK 12 1 P16949;P16949-2;A2A2D0 P16949 STMN1 Stathmin 1 16805300.0 6444200.0 7458900.0 2902200.0 True False 5358637.826465015 7418717.425224275 3509036.6017433316 1.0 1.3844409093268117 0.6548374261109884 22.353434881432396 -6.763515385162214 1.5990238317219978 1.222323048725216 0.6516776909494002 0.705244656075156 0.16179004525870158 0.27704486003990536 1.3968276791367082 0.07979993905984355 0.19112857198480773 1.7237910235361472e-07 6.763515385162214 -0.5706453577758157 (ac)ASSSGSK(ub)AEFIVGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASSSGSKAEFIVGGK 15 1 U3KPX3;A0A590UJ43;P48729;P48729-2;A0A590UJQ7;E5RG27;D6RGE5;A0A590UK94;A0A5F9W493;P48729-3 U3KPX3 CSNK1A1 Casein kinase I isoform alpha 1 11675700.0 3614100.0 2806600.0 5255000.0 True False 4738120.098994183 2387866.2200411167 4711263.009519425 1.0 0.5039691206957834 0.9943316992998005 22.17588333692456 -10.937764054415188 10.36416986659608 1.0568053818683463 0.7491504099977919 0.2586684101714505 0.20018968442254165 0.11377810419262661 0.0006832268098621828 0.083930241173425 0.0646109428209185 1.1540800816843431e-11 10.937764054415188 -0.30765497187055435 (ac)ASSSGSK(ub)AEFIVGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASSSGSKAEFIVGGK 15 1 U3KPX3;A0A590UJ43;P48729;P48729-2;A0A590UJQ7;E5RG27;D6RGE5;A0A590UK94;A0A5F9W493;P48729-3 U3KPX3 CSNK1A1 Casein kinase I isoform alpha 1 13118900.0 3869400.0 5579500.0 3670000.0 True False 3746568.015002477 7807423.446708127 2708716.902359996 1.0 2.083886750606065 0.7229861813567544 21.83713821164518 -6.6945645986569655 1.850498043953338 1.676614825087718 0.72745403721861 0.3917298998441986 0.4579938820579565 0.4069324955102871 2.7051847523204002 0.19775206637595252 0.5119598576314273 2.020390888811297e-07 6.6945645986569655 -0.949160787869108 (ac)ASSSGSK(ub)AEFIVGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASSSGSKAEFIVGGK 15 1 U3KPX3;A0A590UJ43;P48729;P48729-2;A0A590UJQ7;E5RG27;D6RGE5;A0A590UK94;A0A5F9W493;P48729-3 U3KPX3 CSNK1A1 Casein kinase I isoform alpha 1 22807800.0 5220900.0 4560900.0 13026000.0 True False 7920486.998916528 3746971.760525653 10451405.390501382 1.0 0.47307340584464247 1.3195407544928826 22.917157707876736 -6.738341525304716 1.6926144100469902 0.685887311816682 1.3198770735122252 0.5975699370429328 0.22140208601963815 0.32080975747574564 1.8039856908733032 0.1035039124182676 0.25446827282556755 1.8266631795580412e-07 6.738341525304716 0.6339897616955431 (ac)ASSSGSK(ub)AEFIVGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASSSGSKAEFIVGGK 15 1 U3KPX3;A0A590UJ43;P48729;P48729-2;A0A590UJQ7;E5RG27;D6RGE5;A0A590UK94;A0A5F9W493;P48729-3 U3KPX3 CSNK1A1 Casein kinase I isoform alpha 1 11216900.0 3614100.0 3649800.0 3953000.0 True False 4950330.437380126 3488539.7677253983 3019382.814590526 1.0 0.7047084657992337 0.6099356099122305 22.23909339844745 -13.999999998597628 0.15899113578870233 2.4512114877772713 0.5157243027250767 0.9995390570382136 0.003566281957189522 12.003099010097069 0.12597178507025159 5.372126228743337 0.08575764252912031 1.0000000032290798e-14 13.999999998597628 -1.9354871850521946 (ac)ASSSGSK(ub)AEFIVGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASSSGSKAEFIVGGK 15 1 U3KPX3;A0A590UJ43;P48729;P48729-2;A0A590UJQ7;E5RG27;D6RGE5;A0A590UK94;A0A5F9W493;P48729-3 U3KPX3 CSNK1A1 Casein kinase I isoform alpha 1 12415100.0 3869400.0 5159800.0 3385900.0 True False 3217577.543484643 5132003.133259894 4093876.0353672295 1.0 1.5949897287329786 1.2723472799146756 21.617543487079455 -10.089816456352157 4.594636464784164 0.9999717661407868 1.4336685043365678 0.7066467630302934 0.13171822820552792 3.848784278441241e-05 7.6240000750568865e-06 0.1275440011443559 0.04251187534640443 8.131741111540215e-11 10.089816456352157 0.43369673819578103 (ac)ASSSGSK(ub)AEFIVGGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASSSGSKAEFIVGGK 15 1 U3KPX3;A0A590UJ43;P48729;P48729-2;A0A590UJQ7;E5RG27;D6RGE5;A0A590UK94;A0A5F9W493;P48729-3 U3KPX3 CSNK1A1 Casein kinase I isoform alpha 1 19488300.0 5220900.0 4373300.0 9894100.0 True False 6758557.969324794 4129922.010560338 8093475.322039059 1.0 0.6110655600358686 1.1975151147290712 22.688284029969186 -6.727884017484379 1.7307557548474015 0.7653899556405 1.197044696251484 0.5494728255607527 0.16352845621063652 0.34023880819699437 1.9956611912932196 0.07490171061540801 0.18632389413143213 1.871181790726725e-07 6.727884017484379 0.43165474061098397 (ac)ASSVGNVADSTEPTK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASSVGNVADSTEPTKR 16 1 O15294 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 39642200.0 14061000.0 18884000.0 6697200.0 True False 18434107.1669177 16066580.809255471 6004237.988078684 1.0 0.8715681569915656 0.3257135229664953 24.13587420719314 -6.943483316188364 0.6263200636457219 1.005956758393957 0.16209136517567693 0.9985854703677999 0.010994618026728891 0.08621286103794647 0.047638725831341724 0.011009435672965053 0.04630836516532489 1.1389815360314711e-07 6.943483316188364 -0.8438653932182801 down (ac)ASSVGNVADSTEPTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASSVGNVADSTEPTKR 16 1 O15294 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 62236000.0 23191000.0 24439000.0 14606000.0 True False 22454814.39911159 34197620.14770133 10780250.429392373 1.0 1.5229526969082556 0.480086374252948 24.42052146174261 -6.770383298496476 1.5731752226773303 1.2998051713831813 0.4741614219211235 0.7319654313909845 0.22041900461140287 0.2658060278543695 1.2983499276039914 0.1104398978979582 0.2627802067105073 1.69674548221019e-07 6.770383298496476 -0.8256437494620579 down (ac)ASSVGNVADSTEPTK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASSVGNVADSTEPTKR 16 1 O15294 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 96301000.0 48094000.0 27702000.0 20505000.0 True False 72962114.14236853 22758361.66328612 16452177.762339234 1.0 0.31192026068321554 0.22548932354449944 26.120644197696116 -13.999999999999998 0.29253945307533896 7.014842068471448 0.20253347043934733 0.9996331472667145 0.006637358640074982 16.1185401636427 0.1715778120566734 58.432300806583505 0.0322729488008984 1.0000000000000041e-14 13.999999999999998 -6.8123085980321 (ac)ASSVGNVADSTEPTK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASSVGNVADSTEPTKR 16 1 O15294 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 37012900.0 14061000.0 16282000.0 6669900.0 True False 19259731.684237294 15562607.402626183 5094606.990902436 1.0 0.8080386402975208 0.2645211820407657 24.19908426871603 -6.9527438126416 0.5278675782850203 1.0087054550609356 0.039270882113765636 0.9993993602919172 0.00763378438390347 0.0824024146856557 0.03154536318240749 0.008543664640356375 0.04493387235320954 1.1149520422623749e-07 6.9527438126416 -0.96943457294717 down (ac)ASSVGNVADSTEPTK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASSVGNVADSTEPTKR 16 1 O15294 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 67463400.0 23191000.0 37188000.0 7084400.0 True False 19284344.03549706 36987660.86275995 8565715.285435345 1.0 1.9180149863887543 0.4441797589624138 24.200926737176886 -6.738228139046988 1.692909632194037 1.5473115895041534 0.44359314070301187 0.5971316232534299 0.3857295119159935 0.3210045885005632 1.805644066479844 0.18029343293117758 0.44333414654671716 1.8271401497947145e-07 6.738228139046988 -1.1037184488011416 (ac)ASSVGNVADSTEPTK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASSVGNVADSTEPTKR 16 1 O15294 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 90039300.0 48094000.0 32674000.0 9271300.0 True False 62258631.07447124 30855663.177245665 7584018.531571406 1.0 0.49560458758460935 0.12181473316526525 25.891770519788565 -8.122760536479992 0.37814231585853564 1.0799727058132425 5.847303718024957e-24 0.9977441912972188 0.017090577226788715 0.0949417230788395 0.08865672855622418 0.05890976807436748 0.08459570182786348 7.537710673310078e-09 8.122760536479992 -1.0799727058132425 (ac)ATAEVLNIGK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATAEVLNIGKK 11 1 P22234;E9PBS1;P22234-2 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 14821000.0 3977400.0 6925900.0 3917700.0 True False 5214409.91719639 5892582.716946746 3512333.9852320175 1.0 1.1300574390045244 0.6735822539859849 22.314072570352742 -6.830557134363157 1.325335807370603 1.0694692860161543 0.6611514761184951 0.9069963707048909 0.05855830921106345 0.1801272621162558 0.618579427961398 0.03468848174155114 0.0798302994963574 1.4772121316040314e-07 6.830557134363157 -0.4083178098976592 (ac)ATAEVLNIGK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATAEVLNIGKK 11 1 P22234;E9PBS1;P22234-2 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 24803700.0 6777100.0 9453800.0 8572800.0 True False 6561964.670096991 13228751.640915714 6327326.501512731 1.0 2.0159742250974637 0.9642426955369768 22.645696395668608 -6.654043775913791 1.9939830010616657 1.6571489112817803 0.9686538510537712 0.21062134515408693 0.43320145162997115 0.49872524123532075 3.805247030407291 0.17591218883005974 0.4799848294058991 2.2179728418236554e-07 6.654043775913791 -0.6884950602280091 (ac)ATAEVLNIGK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATAEVLNIGKK 11 1 P22234;E9PBS1;P22234-2 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 37877000.0 11264000.0 12083000.0 14530000.0 True False 17088311.50870461 9926694.245090093 11658139.131274775 1.0 0.5809055060842926 0.6822288513020281 24.026506515973182 -9.865136153469733 6.4453938910528 1.0000000178531074 0.631567178693127 0.9463212633083481 0.041365082469363504 1.0617291027733194e-08 1.851911434055893e-09 0.04005157066996383 0.013350522959840674 1.3641554000734977e-10 9.865136153469733 -0.3684328391599805 (ac)ATAEVLNIGK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATAEVLNIGKK 11 1 P22234;E9PBS1;P22234-2 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 15804000.0 3977400.0 6722100.0 5104500.0 True False 5447952.265193471 6425095.394987917 3898922.2304774444 1.0 1.1793597084242706 0.7156674729672918 22.377282631875634 -6.801827109505818 1.448379795954156 1.0987352237030648 0.7089705870403296 0.837447472766406 0.07697139027673318 0.21817311645478896 0.903372621601768 0.0418029325557873 0.09711472163810263 1.5782394340017484e-07 6.801827109505818 -0.3897646366627352 (ac)ATAEVLNIGK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATAEVLNIGKK 11 1 P22234;E9PBS1;P22234-2 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 24696600.0 6777100.0 12728000.0 5191500.0 True False 5635458.9264355665 12659431.737689802 6277018.647216093 1.0 2.246388786245117 1.1138433851005483 22.426101671102884 -6.623384507727842 2.104957664638393 1.8250880865360042 1.1183074773549362 0.09402070832705911 0.5355401835585002 0.5764429399128199 4.858316464582307 0.20874479050971748 0.5934056209110466 2.380211188228476e-07 6.623384507727842 -0.706780609181068 (ac)ATAEVLNIGK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATAEVLNIGKK 11 1 P22234;E9PBS1;P22234-2 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 30582400.0 11264000.0 13976000.0 5342400.0 True False 14581470.0466346 13198223.314108627 4370138.017653093 1.0 0.9051366749647286 0.29970489968957004 23.79763283806563 -6.934542234052353 0.7085127440888034 1.0078399794367776 0.1596967353241744 0.9973581378499473 0.015943464063181652 0.09034686111395614 0.06662162362375451 0.014939963489957984 0.053479169831674216 1.1626734784170768e-07 6.934542234052353 -0.8481432441126032 down (ac)ATEEK(ub)KPETEAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATEEKKPETEAAR 13 2 P61964;V9GZ59;V9GYQ5 P61964 WDR5 WD repeat-containing protein 5 1 3155730.0 966980.0 1363900.0 824850.0 True False 1267720.1442476402 1160411.4364405614 739502.4345199048 1.0 0.9153529994029055 0.5833325579588237 20.273804867587476 -6.945324800426436 0.6080095195492683 1.0036835524216061 0.47777038210610917 0.9987814332311997 0.006277121004069105 0.0854191603590439 0.044163002650802106 0.006392630145374184 0.027977376134064806 1.1341622804207456e-07 6.945324800426436 -0.5259131703154969 (ac)ATEEK(ub)KPETEAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATEEKKPETEAAR 13 2 P61964;V9GZ59;V9GYQ5 P61964 WDR5 WD repeat-containing protein 5 1 6180900.0 2309300.0 1912100.0 1959500.0 True False 3503376.9324442074 1570870.81569451 1572203.9661206414 1.0 0.44838761172026037 0.44876814468940374 21.740314787071057 -10.312900554971844 8.288371259276017 1.0000011131334345 0.4485778794021098 0.9999996423347592 0.00015535193412099274 3.195577027173741e-09 2.647510316614675e-10 0.00015041916594017943 5.013962113903524e-05 4.865185962770893e-11 10.312900554971844 -0.5514232337313247 (ac)ATEEK(ub)KPETEAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATEEKKPETEAAR 13 2 P61964;V9GZ59;V9GYQ5 P61964 WDR5 WD repeat-containing protein 5 1 7774000.0 2309300.0 2937300.0 2527400.0 True False 2989434.373108423 2773836.6729057883 2067439.1333139443 1.0 0.9278801026234085 0.6915820437175929 21.511441109163506 -6.949454514181895 0.5648075417859387 1.0030161859654483 0.6050594492583478 0.9991577246849833 0.003822871966551891 0.08370567059581943 0.036875658958156324 0.0040745069695879545 0.019663915696694824 1.1234286257725866e-07 6.949454514181895 -0.3979567367071005 (ac)ATETVELHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATETVELHK 9 0 P82979;F8VZQ9;F8VS12 P82979 SARNP SAP domain-containing ribonucleoprotein 0 8772300.0 1326200.0 3553600.0 3892500.0 False True 1738661.042939068 3023416.7318243105 3489741.439496552 1.0 1.7389339596138103 2.007143056243684 20.729545271758834 -10.624975470905493 0.21171440686365986 8.749841352627474e-19 2.204007280611902 0.9993240779622345 0.011072011658080158 2.4066314830553828 0.10968921213343111 1.3956468155691708 0.15301404580462769 2.3715076454072785e-11 10.624975470905493 2.204007280611902 (ac)ATETVELHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATETVELHK 9 0 P82979;F8VZQ9;F8VS12 P82979 SARNP SAP domain-containing ribonucleoprotein 0 9623400.0 2152700.0 1028500.0 6442200.0 False True 2084363.7168284042 1439185.413556645 4754794.558142661 1.0 0.6904675042734522 2.2811731559872 20.99117561598073 -6.856244383328003 1.2046899062368195 0.833476815057024 2.352808129755421 0.9488911455178263 0.15567418853427586 0.1507259974502711 0.41783458214371777 0.10093400997610066 0.23468290306432213 1.3923730754604505e-07 6.856244383328003 1.519331314698397 up (ac)ATETVELHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATETVELHK 9 0 P82979;F8VZQ9;F8VS12 P82979 SARNP SAP domain-containing ribonucleoprotein 0 8882700.0 1326200.0 2820700.0 4735800.0 False True 1816531.979207416 2696072.1471924623 3617301.5768625853 1.0 1.4841864487124552 1.9913228163706074 20.792755333281725 -6.970541323642044 0.2449146108536408 0.8286473642561121 2.6616200861216006 0.9999863014213043 0.0014980033909200645 0.07612746726504623 0.008399353063703605 0.01171223116740734 0.049018762264224504 1.0701845487202972e-07 6.970541323642044 1.8329727218654885 (ac)ATFISVQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATFISVQLK 9 0 Q8WUM4;Q8WUM4-2;A0A3B3IT07;Q8WUM4-3;C9IZF9;F8WEQ7;F8WBR8 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 5866800.0 2357000.0 1601200.0 1908600.0 False True 2282178.3251565713 2240567.5101476903 1408680.403227324 1.0 0.9817670623937653 0.6172525554639469 21.12198009485416 -6.917292944090188 0.8445570406554789 1.0088539557406582 0.5619810620434073 0.9933953832668424 0.014326756447418055 0.09979099330462399 0.11405995691618749 0.01217017952596419 0.03556340475722278 1.2097818257135912e-07 6.917292944090188 -0.4468728936972509 (ac)ATFISVQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATFISVQLK 9 0 Q8WUM4;Q8WUM4-2;A0A3B3IT07;Q8WUM4-3;C9IZF9;F8WEQ7;F8WBR8 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 32203200.0 8644200.0 12431000.0 11128000.0 False True 13113883.375669777 10212590.926153697 8928545.922424333 1.0 0.7787617621414221 0.6808468297796126 23.644591634073944 -13.999999999999998 0.11052172274819178 2.0665398766290166 0.5025671749618519 0.9997404119473741 0.0021508566948635907 12.009603611956075 0.10096664891691812 2.8554558537139356 0.15832935662864275 1.0000000000000041e-14 13.999999999999998 -1.5639727016671647 (ac)ATFISVQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATFISVQLK 9 0 Q8WUM4;Q8WUM4-2;A0A3B3IT07;Q8WUM4-3;C9IZF9;F8WEQ7;F8WBR8 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 4579840.0 2357000.0 973140.0 1249700.0 False True 1959949.932804389 967897.5016668338 1511006.4920400553 1.0 0.49383787078781155 0.7709413729145804 20.902385370288435 -10.102628188850638 5.335805965550691 1.0000059866780084 0.6323896218509394 0.7011850053771823 0.11312703102570877 8.056847713069361e-06 1.3548522525441729e-06 0.10953656019186916 0.036511592263907475 7.895357710957925e-11 10.102628188850638 -0.36761636482706905 (ac)ATFISVQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATFISVQLK 9 0 Q8WUM4;Q8WUM4-2;A0A3B3IT07;Q8WUM4-3;C9IZF9;F8WEQ7;F8WBR8 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 24275700.0 8644200.0 7988400.0 7643100.0 False True 11190087.302656144 7543838.517632037 6252134.224828601 1.0 0.6741536784830435 0.5587207727454064 23.415717956166393 -13.999999999999998 0.1445773659563559 2.563946082277157 0.423448410346514 0.9995853318228802 0.0038049678947061267 11.94144322844513 0.11944351083516941 5.256851696645592 0.12134176640315186 1.0000000000000041e-14 13.999999999999998 -2.140497671930643 (ac)ATFVSELEAAK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATFVSELEAAKK 12 1 Q96BN2 Q96BN2 TADA1 Transcriptional adapter 1 1 3067030.0 596630.0 1175800.0 1294600.0 True False 782187.707773139 1000375.2232325029 1160647.210680085 1.0 1.2789452113489947 1.4838474181400867 19.577155338462056 -6.974497476207322 0.10506818252212527 0.5340286474064735 2.2339771315820105 0.9999996853253625 0.0001110878075740506 0.07486855465069668 0.00309471069614057 0.017310858087737458 0.03240912363624192 1.0604801010666546e-07 6.974497476207322 1.699948484175537 (ac)ATFVSELEAAK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATFVSELEAAKK 12 1 Q96BN2 Q96BN2 TADA1 Transcriptional adapter 1 1 1459400.0 596630.0 862770.0 0.0 True False 817220.2343195004 824649.9686011418 0.0 1.0 1.0090914712700771 0.0 19.640365399984947 -7.016711753773471 1.09699624751962 1.024829612904829 1.99312560012146e-21 0.985235716491964 0.05754173897504277 0.08889268562462255 0.2082057093671831 0.04420228079211547 0.08033687504413625 9.622507233252327e-08 7.016711753773471 -1.024829612904829 down (ac)ATLK(ub)DQLIYNLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATLKDQLIYNLLK 13 1 P00338;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8;F5H8H6;F5GXC7;F5GWW2;F5GZQ4;F5GXU1 P00338 LDHA L-lactate dehydrogenase A chain 1 125581000.0 20690000.0 24867000.0 80024000.0 True False 31388242.641610283 20429289.563242212 64207221.32423486 1.0 0.6508580233848398 2.045581909677148 24.903720922083256 -6.840403289436313 1.2804853083934213 0.8142717106997271 2.0918332321246162 0.9251515468593295 0.162121620749168 0.16832764272251663 0.535947504115716 0.09927073608705111 0.22873029028402042 1.4440981464763805e-07 6.840403289436313 1.277561521424889 up (ac)ATLK(ub)DQLIYNLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATLKDQLIYNLLK 13 1 P00338;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8;F5H8H6;F5GXC7;F5GWW2;F5GZQ4;F5GXU1 P00338 LDHA L-lactate dehydrogenase A chain 1 101984000.0 20690000.0 15887000.0 65407000.0 True False 26783612.860872667 15002874.48420463 53503597.13249389 1.0 0.5601512597324707 1.9976243462903245 24.674847244175705 -6.824600251819938 1.3520462093874306 0.7639694245701095 2.0321600896422667 0.8945971750162485 0.19524670388222728 0.18757368011133502 0.6724964313546454 0.11344663578270042 0.26118618915158864 1.4976135065156423e-07 6.824600251819938 1.268190665072157 (ac)ATLVVNK(ub)LGAGVDSGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATLVVNKLGAGVDSGR 16 1 P36406-3;P36406-2;P36406;D6RD22;D6R9E9;D6RBN4 P36406-3 TRIM23 E3 ubiquitin-protein ligase TRIM23 1 12352400.0 1523800.0 2073100.0 8755500.0 True False 1475427.803085949 2900899.6410736786 6462171.890630221 1.0 1.9661413693074419 4.379863167221186 20.492701896615134 -6.9554766387309215 0.4950908209855245 0.9495343427007797 5.499709802194713 0.9995638942501459 0.029682939053069044 0.08135841858704404 0.027417494147147496 0.035140435659857985 0.1990850323424432 1.1079581622922776e-07 6.9554766387309215 4.550175459493933 (ac)ATLVVNK(ub)LGAGVDSGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATLVVNKLGAGVDSGR 16 1 P36406-3;P36406-2;P36406;D6RD22;D6R9E9;D6RBN4 P36406-3 TRIM23 E3 ubiquitin-protein ligase TRIM23 1 8380500.0 1523800.0 2005500.0 4851200.0 True False 1267107.2157858831 1994695.973439416 5865563.490585508 1.0 1.5742124648878026 4.629098009632577 20.27310717204941 -6.938430654099355 0.6740038270283082 0.9646011676111296 5.416217313157413 0.9979510590589887 0.07209733757177325 0.08848990375480109 0.05792472684766232 0.06937343535818022 0.26479742420105995 1.1523100400548263e-07 6.938430654099355 4.451616145546284 (ac)ATNFLAHEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATNFLAHEK 9 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;E9PK06;E9PK72;E9PKK3;E9PNW6;E9PJD0;P29692;E9PK01;P29692-4;E9PQZ1;P29692-3;E9PL71;E9PN91 E9PI39;P29692;P29692-3 EEF1D Elongation factor 1-delta 0 42057700.0 10690000.0 6132700.0 25235000.0 False True 10350651.801410161 8581519.091608012 18625196.466227345 1.0 0.8290800672513083 1.7994225700539814 23.303218284211844 -6.861408977048256 1.1785024819087369 0.9068876700310763 1.847712544851579 0.955336004526135 0.089382163360131 0.1453625661173368 0.38281638566216447 0.05911703669599985 0.13823172831240949 1.3759131550700974e-07 6.861408977048256 0.9408248748205027 (ac)ATNFLAHEK(ub)IWFDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATNFLAHEKIWFDK 14 1 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;E9PK06;E9PK72;E9PKK3;E9PNW6;E9PJD0;P29692;E9PK01;P29692-4;E9PQZ1;P29692-3;E9PL71;E9PN91 E9PI39;P29692;P29692-3 EEF1D Elongation factor 1-delta 1 5267600.0 0.0 2512100.0 2755500.0 True False 0.0 3515194.6304284357 2033751.8867719246 0.0 (ac)ATNFLAHEK(ub)IWFDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATNFLAHEKIWFDK 14 1 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;E9PK06;E9PK72;E9PKK3;E9PNW6;E9PJD0;P29692;E9PK01;P29692-4;E9PQZ1;P29692-3;E9PL71;E9PN91 E9PI39;P29692;P29692-3 EEF1D Elongation factor 1-delta 1 20676200.0 4959300.0 7832200.0 7884700.0 True False 7523620.673394773 6434482.716742087 6326285.589013223 1.0 0.8552375240681492 0.8408565321992377 22.842995682086435 -13.999999999848656 0.326437714659113 2.542455529101917 0.8382022060318013 0.9997073942489952 0.001229400639663043 18.52696197428099 0.18251835576390246 19.583558903073218 0.004670699302300605 1.000000000348482e-14 13.999999999848656 -1.7042533230701156 (ac)ATNFLAHEK(ub)IWFDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATNFLAHEKIWFDK 14 1 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;E9PK06;E9PK72;E9PKK3;E9PNW6;E9PJD0;P29692;E9PK01;P29692-4;E9PQZ1;P29692-3;E9PL71;E9PN91 E9PI39;P29692;P29692-3 EEF1D Elongation factor 1-delta 1 16493900.0 4959300.0 7022300.0 4512300.0 True False 6419911.612417874 6631502.831902197 3691107.700107824 1.0 1.0329585876346097 0.5749468096987826 22.614122004178885 -6.889607877575275 1.0247224635282293 1.024841442523168 0.5358581931756593 0.980645294266292 0.029017183141628097 0.11946095826955125 0.22372199582389882 0.02158757619973918 0.05374161630102292 1.2894132313552792e-07 6.889607877575275 -0.4889832493475087 (ac)ATPGNLGSSVLASK(ub)TK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATPGNLGSSVLASKTK 16 1 P48426 P48426 PIP4K2A Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 1 3878500.0 1634000.0 1061900.0 1182600.0 True False 1582129.5644063794 1485922.2077353457 872841.582760471 1.0 0.9391912275483386 0.5516878025649968 20.593436319749674 -6.934574376317545 0.7082416786382734 1.0050128451891551 0.46200065719286865 0.9973632947939598 0.01019591056253232 0.09033141466953486 0.06654876546932251 0.009556096703307542 0.03422356959061981 1.1625874317875479e-07 6.934574376317545 -0.5430121879962865 (ac)ATVTATTK(ub)VPEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATVTATTKVPEIR 13 1 Q9Y230;X6R2L4;M0R0Z0;M0QXZ7 Q9Y230 RUVBL2 RuvB-like 2 1 11067600.0 2974600.0 6102000.0 1991000.0 True False 3899729.4060673746 5191605.385409704 1784990.4190205843 1.0 1.3312732358641015 0.45772160915662913 21.89494259123025 -6.80394950998022 1.4396925814302668 1.1818780984688475 0.44445055171604503 0.8434484849392139 0.14247027078328875 0.2151824958603132 0.8800721624298785 0.07783472153468608 0.1806005928899456 1.5705453815051025e-07 6.80394950998022 -0.7374275467528024 down (ac)ATVTATTK(ub)VPEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATVTATTKVPEIR 13 1 Q9Y230;X6R2L4;M0R0Z0;M0QXZ7 Q9Y230 RUVBL2 RuvB-like 2 1 27536000.0 10626000.0 12030000.0 4880000.0 True False 10288683.446378328 16833641.73562124 3601781.6031380827 1.0 1.6361317580964911 0.35007215664759606 23.29455504907706 -6.7721994507169105 1.5659582395253304 1.363837796994673 0.3422150286870385 0.7389420236794966 0.2682639307377861 0.2628809021544672 1.272508672114806 0.13500424596396882 0.3207321496750111 1.6896647710864464e-07 6.7721994507169105 -1.0216227683076344 (ac)ATVTATTK(ub)VPEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATVTATTKVPEIR 13 1 Q9Y230;X6R2L4;M0R0Z0;M0QXZ7 Q9Y230 RUVBL2 RuvB-like 2 1 27859000.0 11991000.0 5742000.0 10126000.0 True False 18191223.65952387 4717295.237549236 8124591.661616531 1.0 0.25931709300267625 0.44662150351622804 24.116739255477487 -10.879619300443546 11.073487427110079 1.0300532002749714 0.35296929825945217 0.9408662543567679 0.07646670538849912 0.037408058525750694 0.00040666505034085096 0.04881727360740002 0.024679523042417183 1.3194128199810513e-11 10.879619300443546 -0.6770839020155193 (ac)ATVTATTK(ub)VPEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATVTATTKVPEIR 13 1 Q9Y230;X6R2L4;M0R0Z0;M0QXZ7 Q9Y230 RUVBL2 RuvB-like 2 1 25098500.0 10626000.0 12860000.0 1612500.0 True False 8835989.81161622 12790720.627489852 1949666.2946423849 1.0 1.4475707759049872 0.22065058201846943 23.074960324511338 -6.8079918393743455 1.4229768908750329 1.2445078344894664 0.2001618304251056 0.8545126623949175 0.19336717532290176 0.20955332201698182 0.8366644014749445 0.10686240881603747 0.24742509694080417 1.5559948693064003e-07 6.8079918393743455 -1.0443460040643608 down (ac)AVNVYSTSVTSDNLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVNVYSTSVTSDNLSR 16 0 Q15691 Q15691 MAPRE1 Microtubule-associated protein RP/EB family member 1 0 7446800.0 1062300.0 3399800.0 2984700.0 False True 1392685.5873278326 2892563.092316601 2675871.875264055 1.0 2.0769677798322066 1.9213754343493221 20.40943816121767 -10.286102058303955 6.2102861635490045 0.9999631769801728 1.9991716070907624 0.9821380006843862 0.06352030905265298 3.238715117390869e-05 3.7229483197449253e-06 0.06150552309962434 0.020501091592239055 5.1748520970791336e-11 10.286102058303955 0.9992084301105896 (ac)AVNVYSTSVTSDNLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVNVYSTSVTSDNLSR 16 0 Q15691 Q15691 MAPRE1 Microtubule-associated protein RP/EB family member 1 0 5509900.0 1062300.0 1496600.0 2951000.0 False True 1455061.017578071 1430475.2634056206 2254034.5777527536 1.0 0.9831032830407531 1.5490996944613107 20.47264822274056 -6.90002147412087 0.9611594001083027 0.97648109142787 1.6085305649316748 0.9865758944342874 0.03046268927727368 0.11138930636567035 0.17734374098950037 0.02377003807727497 0.06185038736423706 1.25886316451904e-07 6.90002147412087 0.6320494735038048 (ac)AVPETRPNHTIYINNLNEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVPETRPNHTIYINNLNEK 19 1 P09012;M0QXK2;M0R221;M0R2B8;M0R268;M0R0G9 P09012 SNRPA U1 small nuclear ribonucleoprotein A 0 32762800.0 4426800.0 10769000.0 17567000.0 False True 5803577.669192179 9162307.177233215 15749335.354562832 1.0 1.578734308299272 2.7137287122333005 22.46851110652157 -6.96042650113727 0.4293803802156467 0.954618883192623 3.381324855148607 0.9997856925667722 0.010420301357812503 0.07954911387270076 0.020570941078644465 0.014791348341162974 0.09425329485409509 1.0954019226384062e-07 6.96042650113727 2.426705971955984 (ac)AVPETRPNHTIYINNLNEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVPETRPNHTIYINNLNEK 19 1 P09012;M0QXK2;M0R221;M0R2B8;M0R268;M0R0G9 P09012 SNRPA U1 small nuclear ribonucleoprotein A 0 19957800.0 5133200.0 3154600.0 11670000.0 False True 4970249.375771622 4414248.231021674 8613276.90750439 1.0 0.8881341553081268 1.7329667500168833 22.24488680826733 -6.873551729695394 1.1151857144898902 0.9351530745652794 1.785891211784285 0.9680987764874736 0.06692207637822276 0.13349250304125387 0.3081410850788053 0.04646602865063205 0.11073689119748992 1.3379758366503144e-07 6.873551729695394 0.8507381372190055 (ac)AVPETRPNHTIYINNLNEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVPETRPNHTIYINNLNEK 19 1 P09012;M0QXK2;M0R221;M0R2B8;M0R268;M0R0G9 P09012 SNRPA U1 small nuclear ribonucleoprotein A 0 30539800.0 4426800.0 10124000.0 15989000.0 False True 6063507.589771823 9676688.204409003 12212727.503791528 1.0 1.59588951793052 2.0141357659702552 22.531721168044463 -7.633517124890446 0.10986386579864459 2.734566151411037e-20 3.3443180167395576 0.999993822247001 0.0010342812346126194 0.13982419398098683 0.011983079029244977 0.14592075903476776 0.2019968993750972 2.3253207931381447e-08 7.633517124890446 3.3443180167395576 (ac)AVQISK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVQISKK 7 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 1 47844100.0 11334000.0 7764100.0 28746000.0 True False 14858983.758612122 6605726.544224768 25771639.67110283 1.0 0.44456112554777866 1.734414687422068 23.824832114102485 -6.789701298976948 1.4977488207694523 0.6894456940052963 1.7479796165932908 0.8002922446390193 0.23607576367699923 0.23579450531647198 1.0449936264918929 0.1240737688989679 0.2905225808966919 1.6229259369276492e-07 6.789701298976948 1.0585339225879946 (ac)AVQISK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVQISKK 7 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 1 81184000.0 14407000.0 19189000.0 47588000.0 True False 13949657.670993079 26851267.769313022 35123275.19060147 1.0 1.9248692980579412 2.5178592922489282 23.733726382508255 -8.48221996728185 0.15905890512561052 6.748001909838424e-14 3.5213191010771534 0.9998735549255742 0.007023277839647797 0.1490891556969907 0.03978737393470974 0.4165342192991198 0.3632949420609756 3.294428093100607e-09 8.48221996728185 3.521319101077086 (ac)AVQISK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVQISKK 7 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 1 86443100.0 12092000.0 9046100.0 65305000.0 True False 18344448.04361293 7431752.777498112 52397438.12580172 1.0 0.4051227248609237 2.8563104216180095 24.12884016096359 -6.8425824804788595 1.270396302090122 0.6835797099847948 2.9411199846005553 0.9288018579608978 0.27855134702282536 0.1657989717320294 0.5186721362753051 0.17185712590723157 0.39623163403930184 1.4368701394770313e-07 6.8425824804788595 2.2575402746157605 up (ac)AVQISK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVQISKK 7 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 1 66051300.0 11334000.0 7353300.0 47364000.0 True False 15524486.089833248 7028406.891888657 36177598.69219975 1.0 0.4527304060964346 2.3303572487267012 23.888042175625376 -6.82871861772934 1.3337968506132154 0.7073153640580255 2.3795112261850386 0.9032531065974252 0.24523981379381954 0.18240044079569673 0.6351014857428912 0.144389345548033 0.3322724242808237 1.48347892966549e-07 6.82871861772934 1.6721958621270132 up (ac)AVQISK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVQISKK 7 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 1 81609000.0 14407000.0 33775000.0 33427000.0 True False 11980058.838316843 33593047.37118743 40416431.15101459 1.0 2.804080332539263 3.3736421245067074 23.51413165794253 -9.709229014008843 0.3133484589579413 8.435303543480211e-23 3.561336831271793 0.9987253925222821 0.03612219944885458 1.0783951948378068 0.13257926389785998 1.2524661107871302 0.19074410569921327 1.9533091568762783e-10 9.709229014008843 3.561336831271793 (ac)AVQISK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVQISKK 7 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 1 73914000.0 12092000.0 11262000.0 50560000.0 True False 15653332.368954679 10635259.799906373 41358598.78940925 1.0 0.6794246457705919 2.642159369939396 23.89996648305604 -6.865006010845707 1.1602702510336032 0.8231791780335249 2.7466650639717165 0.9594351371040344 0.1731501235253114 0.14172852215258191 0.359768993477282 0.11613937758075235 0.2728049798563504 1.3645642502289357e-07 6.865006010845707 1.9234858859381916 up (ac)AVQISK(ub)K(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVQISKKR 8 2 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 2 3910240.0 947600.0 707240.0 2255400.0 True False 1242312.7765714535 601722.5487999283 2022032.8433244762 1.0 0.484356725735823 1.6276358751657545 20.24459701534583 -6.784110095670169 1.5200267686720863 0.7095856614531841 1.6378591168372145 0.7816047956053629 0.218469922223593 0.24424312376766463 1.1148657680164629 0.11317850563013568 0.26613216482921803 1.6439549201715082e-07 6.784110095670169 0.9282734553840304 (ac)AVQISK(ub)K(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVQISKKR 8 2 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 2 4245330.0 803230.0 1399600.0 2042500.0 True False 777731.9033158723 1958467.5788175785 1507507.9763134283 1.0 2.5181782700023247 1.9383388670133552 19.568913395183042 -10.017909633098393 5.793819520756537 0.9999974925340551 2.228258568508128 0.8567905221453659 0.23671844501485426 7.66678607139049e-06 1.2998201109777116e-06 0.22920211646318647 0.07640054960673828 9.596002819528279e-11 10.017909633098393 1.2282610759740729 (ac)AVQISK(ub)K(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVQISKKR 8 2 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 2 5437450.0 947600.0 530750.0 3959100.0 True False 1297953.3279271214 507299.71004445653 3024042.1202239655 1.0 0.39084587953145633 2.3298542830145292 20.30780707686872 -6.82226417470085 1.3620773610512191 0.6724038672316476 2.374266694597027 0.8895082252251472 0.2691195450463999 0.1905540422634394 0.694038175453124 0.1552399377766878 0.35760034781500016 1.5056908987906652e-07 6.82226417470085 1.7018628273653795 up (ac)AVQISK(ub)K(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVQISKKR 8 2 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 2 6837530.0 803230.0 3199900.0 2834400.0 True False 667921.3341223877 3182661.503569581 3427059.9352151165 1.0 4.765024473655157 5.130933479940548 19.34931867061732 -9.9169501097889 0.5639314819845791 1.2691701629827884e-11 5.100659049325257 0.9993443795969208 0.04780675834209817 1.1897424128589027 0.26196090382437126 2.219472115539486 0.06657298628704214 1.2107372107623436e-10 9.9169501097889 5.100659049312565 (ac)AYHSFLVEPISCHAWNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYHSFLVEPISCHAWNK 17 0 O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7;C9JTT6;C9JM51;F8WEB3 O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 36722700.0 8207700.0 14483000.0 14032000.0 False True 10760374.183479872 12322192.85429182 12580103.24444845 1.0 1.1451453865990804 1.1691139201982736 23.359224911554453 -13.949741003531711 0.2538111402663344 2.425910932217659e-05 1.1784442925126342 0.999546835800541 0.0015904999082911563 13.796048226340458 0.15918885394419893 7.043673352507693 0.010840789903910629 1.1226877823669493e-14 13.949741003531711 1.178420033403312 (ac)AYHSFLVEPISCHAWNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYHSFLVEPISCHAWNK 17 0 O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7;C9JTT6;C9JM51;F8WEB3 O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 12281400.0 6607000.0 1992200.0 3682200.0 False True 6397264.401488956 2787695.8491857518 2717721.356367837 1.0 0.4357637380966963 0.42482554820389956 22.609023680981267 (ac)AYHSFLVEPISCHAWNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYHSFLVEPISCHAWNK 17 0 O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7;C9JTT6;C9JM51;F8WEB3 O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 36285700.0 8207700.0 11008000.0 17070000.0 False True 11242308.494752472 10521630.161411919 13038417.567685356 1.0 0.9358958763961208 1.1597633683305566 23.422434973077344 -6.830170165259682 1.3272855852556575 0.9657519458706695 1.1658026517139937 0.9061893076306551 0.028831759245706554 0.18060198390944793 0.6222084379451216 0.01705585571661129 0.03924736506621972 1.4785289574575985e-07 6.830170165259682 0.20005070584332418 (ac)AYHSFLVEPISCHAWNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYHSFLVEPISCHAWNK 17 0 O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7;C9JTT6;C9JM51;F8WEB3 O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 13071910.0 6607000.0 943310.0 5521600.0 False True 5494013.239727875 938228.2017976245 6676141.031006136 1.0 0.17077283232832108 1.2151665348620115 22.389428956415543 -6.695117526101048 1.847975595827018 0.48264685805276014 1.2118227834368682 0.3945778175602914 0.35034859319997613 0.4057678767737015 2.6903648409665775 0.151437063905154 0.391864924870436 2.017820239690275e-07 6.695117526101048 0.7291759253841081 (ac)AYHSGYGAHGSK(ub)HR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYHSGYGAHGSKHR 14 1 E9PIZ0;C9JST7;A6NGW1;O95070 E9PIZ0 YIF1A Protein YIF1A 1 3199120.0 311130.0 818790.0 2069200.0 True False 407894.44298720645 696629.7236184215 1855099.0331679508 1.0 1.7078676495729341 4.547988002930787 18.637836326922947 -6.944804506135796 0.6132383190266517 0.9687181070846878 5.43586659121105 0.9987278875438773 0.05468320419545734 0.08564151831741292 0.0451306183983449 0.055415126849352986 0.23976230473262944 1.135521845877405e-07 6.944804506135796 4.467148484126362 (ac)AYHSGYGAHGSK(ub)HR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYHSGYGAHGSKHR 14 1 E9PIZ0;C9JST7;A6NGW1;O95070 E9PIZ0 YIF1A Protein YIF1A 1 2805330.0 311130.0 577200.0 1917000.0 True False 426163.16897210403 551697.3954548469 1464244.0818542957 1.0 1.2945684555179384 3.435876651156925 18.70104638844584 -6.931923936953213 0.7308324725037344 0.9696486861299306 3.897810426134064 0.9969029333781556 0.060411400478324925 0.09165126611001269 0.07287738888001272 0.0556812589287932 0.19174313961957154 1.169704236996462e-07 6.931923936953213 2.9281617400041333 up (ac)CDK(ub)EFMWALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CDKEFMWALK 10 1 P58546;C9JL85 P58546 MTPN Myotrophin 1 18164800.0 8985000.0 8127800.0 1052000.0 True False 11779422.010863766 6915163.921916262 943149.1314965632 1.0 0.5870546038284933 0.08006752204197527 23.489765415390263 -7.669638419077359 0.5193391984655 1.0145283958554574 9.905706403411142e-24 0.9950966610147978 0.026343979471682693 0.11687815745514944 0.09557107474706551 0.02964599210723951 0.07510618189803168 2.139742835595846e-08 7.669638419077359 -1.0145283958554574 down (ac)CDK(ub)EFMWALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CDKEFMWALK 10 1 P58546;C9JL85 P58546 MTPN Myotrophin 1 20332800.0 8985000.0 9681400.0 1666400.0 True False 12306997.310495125 9253643.735891478 1272830.6405852898 1.0 0.7519010122802402 0.10342332971015189 23.552975476913154 -7.232164095424354 0.6398546868737637 0.9990586611476097 3.867840174664253e-21 0.9968211807560109 0.021311776753280175 0.09160696072248202 0.06768948736171707 0.019979119186654393 0.057138906674913045 5.8591673774915045e-08 7.232164095424354 -0.9990586611476097 down (ac)CDKEFMWALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CDKEFMWALK 10 1 P58546;C9JL85 P58546 MTPN Myotrophin 0 10957200.0 2382200.0 3937300.0 4637700.0 False True 3123087.269257618 3349870.187475192 4157835.2919597 1.0 1.0726149795588267 1.3313221608911523 21.574541452856884 -6.947537132810113 0.5852660482207089 0.9969647284455924 1.4198845830726732 0.9989934976556037 0.004511216771107328 0.08449019999250156 0.04017464220566202 0.004700075368261702 0.02164311735930187 1.1283994536079279e-07 6.947537132810113 0.4229198546270808 (ac)CDKEFMWALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CDKEFMWALK 10 1 P58546;C9JL85 P58546 MTPN Myotrophin 0 11660500.0 2382200.0 5145700.0 4132600.0 False True 3262963.7165343934 4918345.959445616 3156564.9935686355 1.0 1.5073247472912175 0.9673919993573314 21.637751514379776 -8.803878796271862 18.64790412258304 1.0000001544041741 1.2373583733242746 0.20488060929027185 0.22042662130948296 0.0 0.0 0.21342715834809092 0.0711423861160303 1.5708011253258297e-09 8.803878796271862 0.23735821892010045 (ac)DDDIAALVVDNGSGMCK ddPTM_RPMI8226_Bortezomib_1h_R1 2 DDDIAALVVDNGSGMCK 17 0 C9JTX5;C9JUM1;C9JZR7;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8 C9JTX5;C9JUM1;P60709 ACTB Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed 0 212549110.0 35631400.0 85198040.0 91719670.0 False True 46713110.45496839 72486824.53135888 82229398.38560003 1.0 1.5517447634157533 1.760306637359751 25.47732417632788 -11.124712626852025 0.18461867222197104 6.149723812144176e-17 1.950294486791836 0.999452365476022 0.0075063076317922785 3.357647779180469 0.10612326041218746 1.5509850905209817 0.1461442193026053 7.503905793818414e-12 11.124712626852025 1.950294486791836 (ac)DDDIAALVVDNGSGMCK ddPTM_RPMI8226_Bortezomib_2h_R1 2 DDDIAALVVDNGSGMCK 17 0 C9JTX5;C9JUM1;C9JZR7;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8 C9JTX5;C9JUM1;P60709 ACTB Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed 0 172265300.0 66334500.0 27762600.0 78168200.0 False True 64228747.60716944 38848350.96004642 57693603.42426604 1.0 0.6048436628041931 0.8982520378122097 25.936715829898816 -10.273075920227816 7.199859481009309 1.0000014504122583 0.751547850308202 0.4887648392628847 0.11978346750480282 2.7887728667200906e-06 2.8156696253941466e-07 0.11598052110259119 0.03865994789975657 5.3324166987804745e-11 10.273075920227816 -0.24845360010405626 (ac)DDDIAALVVDNGSGMCK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DDDIAALVVDNGSGMCK 17 0 C9JTX5;C9JUM1;C9JZR7;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8 C9JTX5;C9JUM1;P60709 ACTB Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed 0 219323700.0 35631400.0 96398500.0 87293800.0 False True 48805291.48237905 92139295.5227895 66676802.31224445 1.0 1.8878956097630522 1.3661797786069536 25.54053423785077 -10.374462782412992 5.1561037868697275 0.9996267852219333 1.6270376941850448 0.6582373918263671 0.21298959617755703 0.0009143035114816557 0.00011092307420167949 0.20634493054890127 0.06874209657590571 4.222184602130788e-11 10.374462782412992 0.6274109089631116 (ac)DDDIAALVVDNGSGMCK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DDDIAALVVDNGSGMCK 17 0 C9JTX5;C9JUM1;C9JZR7;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8 C9JTX5;C9JUM1;P60709 ACTB Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed 0 111437700.0 66334500.0 15136600.0 29966600.0 False True 55160075.86661543 15055056.131420147 36232477.51009641 1.0 0.27293392720897125 0.6568605452558018 25.717121105333092 -10.71553529710737 6.832729270119108 1.0060920981591759 0.46489723623472723 0.7214562942931886 0.1567373854811911 0.014577288993697299 0.0006068905570271016 0.15208957165726 0.050586773641395404 1.925150572889391e-11 10.71553529710737 -0.5411948619244487 (ac)EEEIAALVIDNGSGMCK ddPTM_RPMI8226_Bortezomib_1h_R1 2 EEEIAALVIDNGSGMCK 17 0 K7EM38;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65 K7EM38;P63261 ACTG1 Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 27013300.0 6659000.0 10803400.0 9550900.0 False True 8730013.485847736 9191574.831323382 8562664.48670201 1.0 1.052870633730851 0.9808306139025998 23.057552451810118 -6.709983764635472 1.7950256468560872 1.0325034402332238 0.9809980833215035 0.4651528112255505 0.022279360268563267 0.37509810228460666 2.35591771757322 0.009876680811751816 0.025094127482497026 1.94991749276242e-07 6.709983764635472 -0.05150535691172031 (ac)EEEIAALVIDNGSGMCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEEIAALVIDNGSGMCK 17 0 K7EM38;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65 K7EM38;P63261 ACTG1 Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 21270700.0 9684300.0 4594000.0 6992400.0 False True 9376877.197417809 6428408.157393517 5160880.6724964585 1.0 0.6855595975133132 0.5503837326479709 23.16067610806559 -13.999999999990468 0.11515863330931612 2.5057186381966563 0.31985775266844163 0.9997169891577282 0.003168684998146433 11.984849784394784 0.10378137599584167 4.158912168570319 0.2045765630374577 1.0000000000219482e-14 13.999999999990468 -2.1858608855282147 (ac)EEEIAALVIDNGSGMCK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EEEIAALVIDNGSGMCK 17 0 K7EM38;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65 K7EM38;P63261 ACTG1 Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 27090800.0 6659000.0 8257500.0 12174300.0 False True 9121012.252708638 7892656.346099111 9298981.077578904 1.0 0.8653268000769601 1.0195119598504447 23.12076251333301 -6.675892305187537 1.9165612957265445 0.9144788178125842 1.0189069156324435 0.3054233577619013 0.05712957803021978 0.4476951479043891 3.1757670918346363 0.023950749732641823 0.06350103151278202 2.1091511049355568e-07 6.675892305187537 0.10442809781985929 (ac)EEEIAALVIDNGSGMCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEEIAALVIDNGSGMCK 17 0 K7EM38;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65 K7EM38;P63261 ACTG1 Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 14220400.0 9684300.0 1396100.0 3140000.0 False True 8052924.537232726 1388578.9321958462 3796559.48228036 1.0 0.17243163347374565 0.47145101940629813 22.941081383499867 -10.437975891381315 6.008210460265554 1.0002847791224057 0.32194132649211343 0.8727097264668173 0.12207415312251925 0.0004658590076974192 4.357749860607185e-05 0.11824558346278222 0.03939926350382418 3.647741957619852e-11 10.437975891381315 -0.6783434526302923 (ac)GCLGNSK(ub)TEDQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCLGNSKTEDQR 12 1 P63092;P63092-4;A0A0A0MR13;Q5JWD1;P63092-2;P63092-3 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 3956100.0 1515100.0 1595300.0 845700.0 True False 1986310.7722492693 1357287.458430695 758195.0765272278 1.0 0.6833207962184702 0.38171019717557025 20.92165992960603 -7.198718908069428 0.23796270841854386 1.1244011396232043 3.1236328875693605e-13 0.9999733777149576 0.0013025003400368316 0.09034717722465282 0.011750156487400194 0.011971701697151383 0.03822429805550742 6.328213049070923e-08 7.198718908069428 -1.124401139622892 down (ac)GCLGNSK(ub)TEDQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCLGNSKTEDQR 12 1 P63092;P63092-4;A0A0A0MR13;Q5JWD1;P63092-2;P63092-3 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 3578730.0 1515100.0 1183500.0 880130.0 True False 2075273.4140379694 1131209.0566888642 672261.4208463341 1.0 0.5450891670644067 0.32393872359125897 20.98486999112892 -10.746158146217013 0.14383413329161215 1.918727504657687 2.9226326798606566e-18 0.9997082400804982 0.004807382431452294 2.739260496236017 0.07963782077858182 1.07239708008524 0.21470896564595987 1.794080202315267e-11 10.746158146217013 -1.918727504657687 (ac)GCLGNSK(ub)TEDQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GCLGNSKTEDQR 12 1 P63092;P63092-4;A0A0A0MR13;Q5JWD1;P63092-2;P63092-3 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 4891340.0 2249100.0 1708200.0 934040.0 True False 1870226.3020239067 1698997.5875488466 1129343.4454869903 1.0 0.9084449222590009 0.6038538995333593 20.83478141967992 -6.949105447468278 0.5685783348189046 1.0038189096349712 0.4937069975205361 0.999129209312897 0.004997130915547568 0.08384692479462279 0.03746419072144554 0.0053027788062514165 0.025369643329692427 1.1243319510368929e-07 6.949105447468278 -0.5101119121144351 (ac)GEEANDDK(ub)KPTTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEEANDDKKPTTK 13 2 Q92989;Q92989-2;E9PJM4;E9PKV5 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 2161810.0 641270.0 775770.0 744770.0 True False 840711.1800675138 660028.1399277757 667708.3447383028 1.0 0.7850831005658468 0.7942184671371707 19.68125073312225 -9.923187832514675 5.286578607818463 1.0000004268632052 0.7896507838516018 0.9985874021204387 0.0037294977913486637 1.8762156364372262e-08 3.827110632018121e-09 0.003611078024327996 0.0012036902354576984 1.1934718158488142e-10 9.923187832514675 -0.21034964301160342 (ac)GEEANDDK(ub)KPTTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEEANDDKKPTTK 13 2 Q92989;Q92989-2;E9PJM4;E9PKV5 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 3782910.0 599390.0 788120.0 2395400.0 True False 580362.6925394986 1102820.425991506 1767972.8795403596 1.0 1.900226255354017 3.0463241387971096 19.146595256043092 -6.967839218869274 0.30542613376869326 0.8136205651522338 4.16912117869249 0.9999602810225072 0.0052776432381101 0.07701030880601052 0.011526910396746155 0.018520976641178976 0.10221301120577844 1.0768638080000079e-07 6.967839218869274 3.355500613540256 (ac)GEEANDDK(ub)KPTTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEEANDDKKPTTK 13 2 Q92989;Q92989-2;E9PJM4;E9PKV5 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 11033800.0 1285100.0 1499000.0 8249700.0 True False 1949590.6533945564 1231491.7382595434 6619143.1790280435 1.0 0.631666825092393 3.395145112899999 20.89473980903641 -6.873305852665363 1.1164169513330975 0.7868626682432892 3.567521211988303 0.9678746879146006 0.21959237993299652 0.1337268024861533 0.30950554276278064 0.1523186953279079 0.3628513153188421 1.33873354986572e-07 6.873305852665363 2.7806585437450138 up (ac)GEEANDDK(ub)KPTTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEEANDDKKPTTK 13 2 Q92989;Q92989-2;E9PJM4;E9PKV5 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 2319660.0 641270.0 783700.0 894690.0 True False 878364.8486701406 749073.5426506656 683382.6487189466 1.0 0.8528045535801846 0.7780168454527747 19.744460794645143 -13.999999999944674 0.08710991883738521 1.7637348661832977 0.5813415373628337 0.9998557590885717 0.0011075174645920555 12.190129068589327 0.08503448367953757 1.741913898254115 0.1771952068273105 1.0000000001273938e-14 13.999999999944674 -1.182393328820464 (ac)GEEANDDK(ub)KPTTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEEANDDKKPTTK 13 2 Q92989;Q92989-2;E9PJM4;E9PKV5 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 3327860.0 599390.0 2062470.0 666000.0 True False 498419.3424792632 2051359.0647417582 805257.5207639249 1.0 4.11572924625634 1.6156225333438534 18.92700053147737 -6.591248632212509 2.223188007209569 3.1070320190738174 1.6228324337141586 0.0 1.3496930803210099 0.6659175988405681 6.206354544985426 0.5063300769068796 1.504701839302431 2.5630162977240566e-07 6.591248632212509 -1.4841995853596588 (ac)GEEANDDK(ub)KPTTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEEANDDKKPTTK 13 2 Q92989;Q92989-2;E9PJM4;E9PKV5 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 13778430.0 1285100.0 834330.0 11659000.0 True False 1663587.2831081422 787898.8020649854 9537181.631442308 1.0 0.4736143453759304 5.732901259994989 20.66586613112886 -6.882270040105724 1.067089451674238 0.6628629657042028 6.122188687670215 0.9754695483575996 0.37040555385131113 0.12563685472505007 0.26031323091323416 0.2668291191192307 0.649130943616843 1.311384239432426e-07 6.882270040105724 5.459325721966013 up (ac)GEEANDDKK(ub)PTTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEEANDDKKPTTK 13 2 Q92989;Q92989-2;E9PJM4;E9PKV5 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 3162810.0 699210.0 1295600.0 1168000.0 True False 916671.0811592715 1102301.5302092466 1047146.5642471339 1.0 1.2025049691926757 1.142336205177168 19.806044634968956 -10.0655732996624 4.2478259394808475 0.9999820575100529 1.1724205871795452 0.9163110432963522 0.024563795169210034 3543296.966756975 4202605.501190589 474.01933914779204 0.0084088404574156 8.598579289291042e-11 10.0655732996624 0.17243852966949236 (ac)GEEANDDKK(ub)PTTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEEANDDKKPTTK 13 2 Q92989;Q92989-2;E9PJM4;E9PKV5 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 3221910.0 699210.0 1023100.0 1499600.0 True False 957726.8324397659 977896.0590607328 1145425.3652314567 1.0 1.0210594774394979 1.1959833706585596 19.869254696491847 -6.929402511233931 0.7516704240177916 0.9972802495605126 1.2313551732933714 0.9964197305246242 0.0052562582294562715 0.09294893233404261 0.07920582097813997 0.00477182621574246 0.015879868334385316 1.1765150546494794e-07 6.929402511233931 0.23407492373285876 (ac)GEEANDDKKPTTK(ub)FELER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEEANDDKKPTTKFELER 18 3 Q92989;Q92989-2;E9PJM4;E9PKV5 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 37044600.0 2100200.0 7231400.0 27713000.0 True False 3186156.9451865577 5940900.170813912 22235513.40296058 1.0 1.864597467425151 6.978787858065991 21.603385902874653 -6.936137017991895 0.6945693941414347 0.9369994828530639 8.214137580482017 0.9976129102379714 0.12890448555899214 0.08957394597430673 0.06297078051515675 0.1220708836121791 0.44816811099783666 1.1584118246793714e-07 6.936137017991895 7.277138097628953 (ac)GEEANDDKKPTTK(ub)FELER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEEANDDKKPTTKFELER 18 3 Q92989;Q92989-2;E9PJM4;E9PKV5 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 40017300.0 2100200.0 3159100.0 34758000.0 True False 2718750.3011312108 2983293.3079279196 28432400.64719712 1.0 1.0973031641363455 10.457893332597347 21.374512224967102 -6.90917131807526 0.9013399224738832 0.7025257740197738 11.646471797227614 0.9906055267993198 0.42993420830929424 0.10496911180683886 0.14175115827156926 0.35055687529314994 0.9622525856208874 1.2326185008118096e-07 6.90917131807526 10.94394602320784 up (ac)GEFK(ub)VHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEFKVHR 7 1 Q969X6;Q969X6-3;Q969X6-2;H3BPD7 Q969X6 CIRH1A Cirhin 1 3070470.0 1003100.0 1349600.0 717770.0 True False 1315073.8140342173 1148244.9406995976 643502.0457360153 1.0 0.8731410575176437 0.4893277007485694 20.326712348425346 -6.951260349997124 0.5448342213043582 1.0054779297310323 0.3391189441807502 0.9992964966030466 0.005758281672685144 0.08298362597568884 0.03389855852335667 0.0062922296568037744 0.03181076268102682 1.118767006166829e-07 6.951260349997124 -0.6663589855502821 down (ac)GEFK(ub)VHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEFKVHR 7 1 Q969X6;Q969X6-3;Q969X6-2;H3BPD7 Q969X6 CIRH1A Cirhin 1 5467500.0 1133900.0 1853700.0 2479900.0 True False 1097904.9651654786 2593892.0769177987 1830339.7945946988 1.0 2.362583428636596 1.6671204272391882 20.06632174915155 -10.262183293596964 5.264295658511597 0.9998674690238368 2.014851927938038 0.7395290913050676 0.2839215814018701 0.00044168581778014073 6.19039071050985e-05 0.2749410633572847 0.09163529636645266 5.467851440088309e-11 10.262183293596964 1.0149844589142014 (ac)GEFK(ub)VHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEFKVHR 7 1 Q969X6;Q969X6-3;Q969X6-2;H3BPD7 Q969X6 CIRH1A Cirhin 1 3027230.0 1003100.0 933130.0 1091000.0 True False 1373973.1777582257 891901.2311517365 833328.2698503073 1.0 0.6491402056384844 0.6065098528414983 20.389922409948237 -13.999999999999998 0.2973244936738019 4.151715412207178 0.5957270616586674 0.9996438546598216 0.0033272100368251295 16.416072277180096 0.17309443711547776 31.780768739660164 0.015585609210550112 1.0000000000000041e-14 13.999999999999998 -3.5559883505485104 (ac)GEFK(ub)VHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEFKVHR 7 1 Q969X6;Q969X6-3;Q969X6-2;H3BPD7 Q969X6 CIRH1A Cirhin 1 5296700.0 1133900.0 2422600.0 1740200.0 True False 942888.0902871845 2409548.9729515505 2104067.7742242953 1.0 2.55549836483527 2.23151378822002 19.846727024585828 -10.50738470823812 5.466283749637709 0.9971729473134449 2.393506076527648 0.9610387310569659 0.13226614953984553 0.004560398838836953 0.0004109774304965654 0.12816239882115799 0.04268871620289849 3.108961126286987e-11 10.50738470823812 1.3963331292142032 (ac)GEFK(ub)VHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEFKVHR 7 1 Q969X6;Q969X6-3;Q969X6-2;H3BPD7 Q969X6 CIRH1A Cirhin 1 9235600.0 1620400.0 1135200.0 6480000.0 True False 2097639.7428592583 1072025.1220790015 5300706.4904148 1.0 0.5110625529137532 2.5269861082959335 21.000335494227407 -6.842618517212514 1.2701206499964084 0.7399138651116127 2.596827308839155 0.9288707654963934 0.22898828648851044 0.16576362559968452 0.5183035227293684 0.14130225532673885 0.32580868260081425 1.4367509163221605e-07 6.842618517212514 1.8569134437275423 up (ac)GK(ub)PSSMDTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKPSSMDTK 9 1 Q9UM82 Q9UM82 SPATA2 Spermatogenesis-associated protein 2 1 2725150.0 567370.0 1163800.0 993980.0 True False 743827.564418896 990165.5764568691 891132.4845294232 1.0 1.3311762346833986 1.1980363825661757 19.50460868610492 -10.120307590226998 4.467948676046526 0.9999710358494198 1.264606308553917 0.8404215627118099 0.05435411706923374 6183900.6049561715 14007094.642901776 1094.7380143650646 0.018606859753403142 7.580405006498098e-11 10.120307590226998 0.26463527270449716 (ac)GK(ub)PSSMDTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKPSSMDTK 9 1 Q9UM82 Q9UM82 SPATA2 Spermatogenesis-associated protein 2 1 2248700.0 567370.0 840690.0 840640.0 True False 777142.0215977323 803545.536009937 642098.1455242553 1.0 1.0339751469852594 0.8262301196944167 19.56781874762781 -6.864945984077936 1.1605651829166896 1.01873558086439 0.8151806211343443 0.9593696972531769 0.018340282367192772 0.14178908330460155 0.36013909667866145 0.012298768577898429 0.028886992693983145 1.3647528688868366e-07 6.864945984077936 -0.20355495973004578 (ac)GK(ub)PSSMDTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKPSSMDTK 9 1 Q9UM82 Q9UM82 SPATA2 Spermatogenesis-associated protein 2 1 4371720.0 1357900.0 2212800.0 801020.0 True False 1129154.01516974 2200879.2071935884 968509.5785019808 1.0 1.9491399557771945 0.8577302701761103 20.106810850623067 -6.6767944457132 1.9131286448091658 1.602251474208878 0.8619709622554705 0.30954185936504097 0.40255332309838227 0.44570805003550523 3.1510982125912874 0.16900810599462796 0.4476107189528095 2.10477440690255e-07 6.6767944457132 -0.7402805119534075 (ac)K(ub)LQTQK(ub)K(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLQTQKKR 8 3 F8VZ44 F8VZ44 AAAS 3 8909700.0 3014800.0 2748100.0 3146800.0 True False 3902718.0305925077 2595165.8192259558 2574114.688894644 1.0 0.6649636993713224 0.6595697328673893 21.8960478018779 (ac)MATPTQTPTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MATPTQTPTK 10 0 K7ENE8;K7EKU3;P58549 K7ENE8 FXYD7 FXYD domain-containing ion transport regulator 7 0 44193000.0 16282000.0 13642000.0 14269000.0 False True 21345859.675112307 11606666.77609952 12792580.757912988 1.0 0.5437432341800708 0.599300330491172 24.347452930523783 -10.075134427682432 5.048604588821169 1.0000091758895284 0.571521782334733 0.9875479440926557 0.02268108959798215 2.3425729765430617e-06 4.291161791349078e-07 0.02196134056467852 0.007320290189731931 8.411347439188162e-11 10.075134427682432 -0.42848739355479537 (ac)MATPTQTPTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MATPTQTPTK 10 0 K7ENE8;K7EKU3;P58549 K7ENE8 FXYD7 FXYD domain-containing ion transport regulator 7 0 39829600.0 10312000.0 4576600.0 24941000.0 False True 9984651.204503424 6404060.246653716 18408203.88603832 1.0 0.6413904817992303 1.8436501695457903 23.251280599965643 -6.826785811528695 1.3423969539925933 0.8079225237852702 1.873886645822576 0.8992536149592271 0.1599595584312021 0.18481374095826308 0.6524892175975787 0.09359336976339946 0.21541430740702902 1.4900957926636043e-07 6.826785811528695 1.0659641220373057 (ac)MATPTQTPTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MATPTQTPTK 10 0 K7ENE8;K7EKU3;P58549 K7ENE8 FXYD7 FXYD domain-containing ion transport regulator 7 0 30842400.0 7028400.0 11119000.0 12695000.0 False True 10662596.644866774 9134727.576856483 10185827.685583832 1.0 0.8567075995746455 0.9552858487324971 23.346055482279194 -10.169621392577467 4.339387507579853 1.0000197785985763 0.9059967241533144 0.548011621770311 0.040244401765629115 56413369.56337812 0.7492636278817937 13207.418338005466 0.013776729151700489 6.76672625157459e-11 10.169621392577467 -0.09402305444526182 (ac)MATPTQTPTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MATPTQTPTK 10 0 K7ENE8;K7EKU3;P58549 K7ENE8 FXYD7 FXYD domain-containing ion transport regulator 7 0 42596000.0 16282000.0 15046000.0 11268000.0 False True 22301895.404505495 14381217.969531601 8606730.471744513 1.0 0.6448428579136043 0.3859192376090938 24.410662992046674 -7.870582366863838 0.18684657202406524 1.2598185399916457 1.2987271610151329e-12 0.9999043176735234 0.0024622656322634954 0.11986034276890023 0.02836985919324488 0.06749893241389021 0.09669463830331161 1.3471552040868318e-08 7.870582366863838 -1.259818539990347 down (ac)MATPTQTPTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MATPTQTPTK 10 0 K7ENE8;K7EKU3;P58549 K7ENE8 FXYD7 FXYD domain-containing ion transport regulator 7 0 22643300.0 10312000.0 5544100.0 6787200.0 False True 8574884.899057643 5514232.832882307 8206372.139532889 1.0 0.6430678542971819 0.9570241742177492 23.03168587539992 -10.219591013971579 7.610984361121229 1.0000002297467483 0.8000460156417799 0.35099894434471357 0.12817213088789725 4.997029158394784e-07 5.126748067108644e-08 0.1241022744857656 0.04136737736472864 6.03127298853003e-11 10.219591013971579 -0.1999542141049684 (ac)MDDK(ub)AFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MDDKAFTK 8 1 P62714;E5RJX4 P62714 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 11993600.0 3617700.0 4634300.0 3741600.0 True False 5488315.3892969275 3807272.9570488357 3002071.1199984606 1.0 0.6937052058767638 0.5469931858968907 22.387931958542744 -13.999999999999979 0.09745359284295758 2.524635878333146 0.22179999006321313 0.999806403308783 0.0026259029915751755 12.10035822223699 0.09244332561521175 3.735325754721482 0.290484893430719 1.000000000000049e-14 13.999999999999979 -2.302835888269933 (ac)MDDK(ub)AFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MDDKAFTK 8 1 P62714;E5RJX4 P62714 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 12783400.0 3617700.0 4566800.0 4598900.0 True False 4683183.9655282255 4312653.565460169 3761947.3886988647 1.0 0.920880665206526 0.8032884072865045 22.159058280635193 -6.965409744614218 0.3509506145750302 1.0112403032545072 0.7089549979181045 0.9999213375581958 0.0007167623743296671 0.07782220754585571 0.01437132617498304 0.001610276616084383 0.010101036592913308 1.0829047417717111e-07 6.965409744614218 -0.30228530533640274 (ac)MDDREDLVYQAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MDDREDLVYQAK 12 1 P62258;B4DJF2;I3L3T1;I3L0W5 P62258 YWHAE 14-3-3 protein epsilon 0 57542700.0 5608200.0 27477000.0 24457500.0 False True 7352404.509886056 23377538.70450711 21926872.512906034 1.0 3.1795773305282142 2.9822723278382086 22.809784711407143 -9.976328859590549 6.233717693958051 0.9999991352879639 3.080924829183325 0.9933025998509423 0.08054943004856933 9.680523698660052e-07 1.5921329346331573e-07 0.07799168280929869 0.025997216760324248 1.0560175611693071e-10 9.976328859590549 2.0809256938953613 (ac)MDDREDLVYQAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MDDREDLVYQAK 12 1 P62258;B4DJF2;I3L3T1;I3L0W5 P62258 YWHAE 14-3-3 protein epsilon 0 53463200.0 18471100.0 5649300.0 29342800.0 False True 17884745.041068975 7905094.950710304 21657040.414868865 1.0 0.4420021047299098 1.2109225133004422 24.0922262161143 -6.712044865287781 1.7876487342542688 0.6576801317183057 1.2092484826704872 0.47492555505425593 0.23506311111284622 0.3709829860419058 2.3122015346859714 0.10458542900174374 0.2650659372036954 1.9406853825154428e-07 6.712044865287781 0.5515683509521815 (ac)MDDREDLVYQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MDDREDLVYQAK 12 1 P62258;B4DJF2;I3L3T1;I3L0W5 P62258 YWHAE 14-3-3 protein epsilon 0 46538100.0 5608200.0 20284600.0 20645300.0 False True 7681703.095906378 19388359.29979798 15769305.343300207 1.0 2.523966242607078 2.0528397344208416 22.872994772930035 -10.374589999439074 6.115921081669532 0.9998072117971529 2.2884029885139223 0.9088560205041145 0.1923365915592419 0.0005056859606600033 5.171089599896882e-05 0.18625558517071641 0.062076367997936546 4.2209479870506005e-11 10.374589999439074 1.2885957767167695 (ac)MDDREDLVYQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MDDREDLVYQAK 12 1 P62258;B4DJF2;I3L3T1;I3L0W5 P62258 YWHAE 14-3-3 protein epsilon 0 18323300.0 12891000.0 2964300.0 2468000.0 False True 10719437.668129554 2948330.7275325186 2984047.3892573044 1.0 0.2750452793151953 0.27837723224319044 23.35372588953336 -10.235316665345104 5.535698168731151 1.0000422915427727 0.27671125929497004 0.9999840839067079 0.0013602640868879193 7.100304040704818e-07 9.808233948839391e-08 0.0013171466620541237 0.00043902334622999934 5.816789325504891e-11 10.235316665345104 -0.7233310322478026 (ac)MDDREDLVYQAK(ub)LAEQAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 MDDREDLVYQAKLAEQAER 19 2 P62258;B4DJF2;I3L3T1;I3L0W5 P62258 YWHAE 14-3-3 protein epsilon 1 6522100.0 0.0 3884700.0 2637400.0 True False 0.0 3305117.9024420036 2364507.1477272185 0.0 (ac)MDDREDLVYQAK(ub)LAEQAER ddPTM_RPMI8226_Bortezomib_2h_R1 2 MDDREDLVYQAKLAEQAER 19 2 P62258;B4DJF2;I3L3T1;I3L0W5 P62258 YWHAE 14-3-3 protein epsilon 1 33844100.0 9065300.0 9053900.0 15724900.0 True False 8777527.01359434 12669169.485464772 11606076.953111902 1.0 1.443364340074737 1.3222490725618727 23.06538310045511 -9.959818243949245 4.770503696673128 0.9999964929598221 1.3828067062630305 0.9301669686824867 0.049445100982627686 8120797.085975936 8477266.686988551 287.7510535451839 0.016926373374299274 1.0969371779249587e-10 9.959818243949245 0.3828102133032084 (ac)MDDREDLVYQAK(ub)LAEQAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MDDREDLVYQAKLAEQAER 19 2 P62258;B4DJF2;I3L3T1;I3L0W5 P62258 YWHAE 14-3-3 protein epsilon 1 7732100.0 0.0 2428800.0 5303300.0 True False 0.0 2321487.5850324538 4050769.7648919667 0.0 (ac)MDDREDLVYQAK(ub)LAEQAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MDDREDLVYQAKLAEQAER 19 2 P62258;B4DJF2;I3L3T1;I3L0W5 P62258 YWHAE 14-3-3 protein epsilon 1 18532800.0 6884600.0 5232700.0 6415500.0 True False 5724849.939493034 5204510.406490367 7756951.388079506 1.0 0.9091086162078956 1.354961522147151 22.448806446920383 -6.853625950209801 1.2175960946748003 0.9513047655439189 1.3740573143001307 0.9453939666330038 0.044952069873176646 0.15352168388050785 0.4361837992524307 0.028860549663532027 0.06695315525081823 1.40079328046057e-07 6.853625950209801 0.4227525487562118 (ac)MDDREDLVYQAK(ub)LAEQAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MDDREDLVYQAKLAEQAER 19 2 P62258;B4DJF2;I3L3T1;I3L0W5 P62258 YWHAE 14-3-3 protein epsilon 1 8553400.0 8553400.0 0.0 0.0 True False 11072544.912720565 0.0 0.0 1.0 0.0 0.0 23.400483513340642 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 (ac)MDEK(ub)VFTK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MDEKVFTK 8 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 74174500.0 24982800.0 31358400.0 17833300.0 True False 32752692.733779352 26679848.954085827 15988081.185092824 1.0 0.814584900574287 0.48814554928497783 24.96511018563943 -6.96245954993006 0.3992613958366305 1.0180916280778318 0.2727335009750627 0.9998508222398448 0.002584329869596954 0.07883394988310068 0.01796881018824619 0.004200740480416357 0.027357835376460127 1.0902860366011053e-07 6.96245954993006 -0.7453581271027692 down (ac)MDEK(ub)VFTK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MDEKVFTK 8 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 106996000.0 32055000.0 40414200.0 34526800.0 True False 31037431.571019914 56551800.817268826 25483195.29820246 1.0 1.8220515666016655 0.8210471681553855 24.887505839872322 -6.688467715086855 1.8716829909547623 1.5161051562102281 0.8245516772978683 0.3633509654023328 0.3477777448195688 0.4199657607705533 2.8511871093252568 0.14870633904376365 0.38801660493056933 2.048954361022083e-07 6.688467715086855 -0.6915534789123599 (ac)MDEK(ub)VFTK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MDEKVFTK 8 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 258069000.0 70281000.0 94373000.0 93415000.0 True False 106621415.22933854 77531400.81038556 74951484.30475098 1.0 0.727165369580009 0.7029683872000126 26.667921995903466 -13.999999999999998 0.3429467643823275 4.212949274197823 0.6993064479052437 0.9997410422298791 0.0021673095500221846 19.977300815530732 0.18803591229488278 46.59980395132091 0.007398146759651882 1.0000000000000041e-14 13.999999999999998 -3.513642826292579 (ac)MDEK(ub)VFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MDEKVFTK 8 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 97342300.0 24982800.0 32417200.0 39942300.0 True False 34219616.2947844 30984900.914655037 30508751.37749028 1.0 0.9054718979820244 0.8915573779282934 25.02832024716232 -13.999999999221597 0.2698147041906211 1.7288769049875172 0.8869303451146924 0.9995829159579046 0.0009838789219140233 14.873959539847046 0.16443146998876457 5.946048256484605 0.005784362769930503 1.0000000017923395e-14 13.999999999221597 -0.8419465598728249 (ac)MDEK(ub)VFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MDEKVFTK 8 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 95235850.0 32055000.0 43262900.0 19917950.0 True False 26655152.777278204 43029834.170686685 24082701.254804503 1.0 1.6143157959074554 0.903491398306051 24.667911115306598 -6.678121639110659 1.908710398478102 1.3893471063656726 0.9062470403699971 0.31544077243087587 0.26047087693881843 0.4427346307571871 3.1168898970982877 0.10956977614639499 0.28966438828139673 2.0983520856198078e-07 6.678121639110659 -0.48310006599567545 (ac)MDEK(ub)VFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MDEKVFTK 8 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 196063000.0 50450000.0 75767000.0 69846000.0 True False 65308519.518174246 71550499.84545419 57134744.68048022 1.0 1.095576815602793 0.8748436666762993 25.960767868309414 -6.789009566694678 1.5001169331075204 1.0534864703217754 0.8725540377480202 0.7981546199688352 0.040606660347281213 0.23682926525865222 1.0528505817806977 0.02130694081596175 0.04992465779787597 1.625512948347907e-07 6.789009566694678 -0.18093243257375524 (ac)MDFQHRPGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDFQHRPGGK 10 1 Q15428;K7EMT0 Q15428 SF3A2 Splicing factor 3A subunit 2 0 2982930.0 1019400.0 418530.0 1545000.0 False True 987039.7049913484 585651.211605117 1140318.150993513 1.0 0.5933410871351424 1.155291064003862 19.912748594622006 -6.712536338692339 1.7857995884136595 0.7506557703167324 1.1540954320791226 0.4773492734299549 0.17129640232698806 0.3699776130832561 2.3014414141537136 0.0762830626741286 0.19322753365263604 1.9384904299896442e-07 6.712536338692339 0.4034396617623902 (ac)MDFSK(ub)LPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDFSKLPK 8 1 P38606;C9JVW8;F8WDJ3 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 18739500.0 5793500.0 5823300.0 7122700.0 True False 5609588.513701568 8148574.0581083335 5257051.19358025 1.0 1.4526152922278035 0.9371545133372552 22.41946351644792 -6.6747461258859015 1.9202178127510503 1.2877049016935982 0.9391718640419798 0.3004277073831826 0.19205150618749814 0.45028262406830205 3.2051572387736145 0.08038401375235935 0.21347139759431308 2.1147248764364358e-07 6.6747461258859015 -0.34853303765161836 (ac)MDFSK(ub)LPK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MDFSKLPK 8 1 P38606;C9JVW8;F8WDJ3 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 25806300.0 7440600.0 11259100.0 7106600.0 True False 6187188.5744693875 11198444.993543627 8592557.202794142 1.0 1.8099407927782456 1.3887660121190082 22.560852574716794 -10.199353853130665 4.374754278753278 0.9998263668622087 1.5993534024687157 0.7297370881254146 0.1719438844600052 18781027.14884091 43786406.37179116 20432.739190092256 0.05886096830457025 6.318967866406755e-11 10.199353853130665 0.599527035606507 (ac)MDGEEK(ub)TYGGCEGPDAMYVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MDGEEKTYGGCEGPDAMYVK 20 1 E5RHG8;Q15369;R4GMY8 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 1 11129900.0 3811500.0 4797400.0 2521000.0 True False 4996913.410618509 4081646.6201187368 2260151.103139575 1.0 0.8168335699884617 0.4523094393304321 22.25260578776747 -6.960141505920116 0.43343461282934365 1.0139628891475434 0.2411216470696722 0.9997754117794981 0.0034115166725396753 0.07965060608926319 0.020944796332210733 0.004769811745647367 0.03024343669157897 1.0961209894834292e-07 6.960141505920116 -0.7728412420778712 down (ac)MDGEEK(ub)TYGGCEGPDAMYVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MDGEEKTYGGCEGPDAMYVK 20 1 E5RHG8;Q15369;R4GMY8 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 1 20619200.0 7356500.0 8544300.0 4718400.0 True False 11160348.332189763 7019502.9080793895 3785806.1718518096 1.0 0.6289680840725245 0.33921935580921064 23.41187872088403 -7.747653758741655 0.22298642739255597 1.1877798324019195 1.6333815052405197e-09 0.9998449646480272 0.0033673552267844842 0.12757831566316813 0.030391084512228352 0.04851159905498751 0.08449582106647528 1.787912419903082e-08 7.747653758741655 -1.187779830768538 down (ac)MDGEEK(ub)TYGGCEGPDAMYVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MDGEEKTYGGCEGPDAMYVK 20 1 E5RHG8;Q15369;R4GMY8 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 1 11855700.0 3811500.0 5785200.0 2259000.0 True False 5220714.55191455 5529590.734901907 1725470.7255653916 1.0 1.0591635838190168 0.3305047055163404 22.315815849290363 -6.887228822523286 1.03867018703303 1.0417922706745932 0.27114061710461806 0.9790632154881724 0.04781202627030313 0.12141897422830812 0.23522944592033762 0.0351961002549335 0.08691049052482337 1.2964959888694628e-07 6.887228822523286 -0.7706516535699752 down (ac)MDGEEK(ub)TYGGCEGPDAMYVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MDGEEKTYGGCEGPDAMYVK 20 1 E5RHG8;Q15369;R4GMY8 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 1 5597300.0 2898600.0 2698700.0 0.0 True False 2410314.329752567 2684161.5674499935 0.0 1.0 1.1136147407485804 0.0 21.20078987030414 -6.9532501865540155 1.1982155154472056 1.0648470943526658 2.1210844172210435e-19 0.9729155217472064 0.08234249463847178 0.10632074907936746 0.3031357426162656 0.057195499336416274 0.10840660034814015 1.1136528003049774e-07 6.9532501865540155 -1.0648470943526658 down (ac)MDGEEK(ub)TYGGCEGPDAMYVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MDGEEKTYGGCEGPDAMYVK 20 1 E5RHG8;Q15369;R4GMY8 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 1 21700000.0 7356500.0 7331300.0 7012200.0 True False 9523134.268294342 6923306.71026936 5736051.551247944 1.0 0.7269987501194154 0.6023281190463894 23.18300504297648 -13.999999999978817 0.10543075286122955 2.3293685228061447 0.35781054983772764 0.9997662884812243 0.00253882063642087 12.04144436696489 0.09775226500237749 3.4387963012685243 0.21750325748727362 1.0000000000487757e-14 13.999999999978817 -1.9715579729684172 (ac)MDGIVPDIAVGTK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MDGIVPDIAVGTKR 14 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A0A0D9SF20;K7EKJ7 P26599 PTBP1 Polypyrimidine tract-binding protein 1 1 5828700.0 2656000.0 3172700.0 0.0 True False 2208581.6807503006 3155608.035368359 0.0 1.0 1.4287939010235449 0.0 21.074688758385193 -6.851536680447277 1.402684396887621 1.2278667392656035 1.1708081253508463e-22 0.8973185356082563 0.19182752451259083 0.17315013766945972 0.6846330148767185 0.11001285941825012 0.23195729430638481 1.4075483420183855e-07 6.851536680447277 -1.2278667392656035 down (ac)MDK(ub)NELVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDKNELVQK 9 1 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 1 5550500.0 2116400.0 1690900.0 1743200.0 True False 2049216.040458789 2366085.1879270095 1286603.625120964 1.0 1.1546294491220546 0.6278516270216743 20.966640659123968 -6.82812170204279 1.3363709479091919 1.0827360989251185 0.6142212725096712 0.9020482992452359 0.06919289382230699 0.1831409972232254 0.6403349486064808 0.040661664007287254 0.09357962371565916 1.48551929790666e-07 6.82812170204279 -0.4685148264154473 (ac)MDK(ub)NELVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MDKNELVQK 9 1 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 1 5911500.0 2269300.0 1938600.0 1703600.0 True False 3442694.0080524976 1592641.6836490668 1366882.7132855929 1.0 0.4626149404866831 0.39703868833199807 21.715106526972303 -13.999999999999998 0.29670278011107626 5.810119611633726 0.3803458183488259 0.9996424650973832 0.005107438040798659 16.37685485981034 0.17289885998275648 48.26923969920632 0.024040009432149588 1.0000000000000041e-14 13.999999999999998 -5.4297737932849 (ac)MDKNELVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDKNELVQK 9 1 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 0 22808000.0 4936000.0 2294000.0 15578000.0 False True 4779309.381829797 3210006.163051961 11497654.47001743 1.0 0.6716464465045752 2.405714623482998 22.18837073075341 -6.857702364604363 1.1972404494029654 0.82281396204686 2.4860933163931658 0.9507861552617429 0.166846540425971 0.14919414121465457 0.40766727632270683 0.1087868222092052 0.25332817417358827 1.387706541127354e-07 6.857702364604363 1.6632793543463058 up (ac)MDKNELVQK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MDKNELVQKAK 11 2 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 1 434686700.0 146873900.0 176632100.0 111180700.0 True False 192553105.22887063 150279279.1865332 99676787.68458149 1.0 0.7804562746880124 0.5176586872806056 27.52068114820196 -6.968735318629493 0.28678819924217336 1.0533619447993756 0.23666983433160635 0.9999707681614391 0.0010660604272927734 0.07671524056614396 0.010491786783153868 0.004672100941878808 0.023921647079648015 1.074644156165682e-07 6.968735318629493 -0.8166921104677692 (ac)MDKNELVQK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MDKNELVQKAK 11 2 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 1 562467500.0 189395400.0 187772300.0 185299800.0 True False 183383146.69680038 262750758.60960856 136764223.50515705 1.0 1.4327966519411512 0.7457840372391389 27.45028581736569 -6.736419397792983 1.6996965714203893 1.2585733321780321 0.7456790584077023 0.5888063225295606 0.18186484459376384 0.3243348336824435 1.8383313810306685 0.08469378093141079 0.2086621772733095 1.8347656559908126e-07 6.736419397792983 -0.5128942737703298 (ac)MDKNELVQK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MDKNELVQKAK 11 2 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 1 302073000.0 206918600.0 13191600.0 81962800.0 True False 313910643.9759446 10837455.913558757 65762816.65442861 1.0 0.03452401542137337 0.2094953386144756 28.225778707263796 -10.113815073082359 6.269295704000139 1.0000024419365352 0.12200967702269871 0.9710753255843525 0.07143174357380411 2.438065838978786e-06 3.446478138278567e-07 0.06916368043533766 0.023054496104322232 7.694580134285918e-11 10.113815073082359 -0.8779927649138365 (ac)MDKNELVQK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MDKNELVQKAK 11 2 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 1 84507400.0 34703900.0 27252500.0 22551000.0 True False 47534869.667634 26048394.438034005 17224918.252423704 1.0 0.5479849765059961 0.362363847273825 25.502482869038747 -13.999999999999998 0.1223192609979165 3.1512243812720615 0.07515206011351021 0.9996816416204856 0.004777878695241819 11.955442326347772 0.10792847095188664 6.233599315963694 0.25492738749764565 1.0000000000000041e-14 13.999999999999998 -3.0760723211585512 (ac)MDKNELVQK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MDKNELVQKAK 11 2 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 1 578810700.0 189395400.0 287014400.0 102400900.0 True False 157490666.738846 285468196.45930237 123812454.74173346 1.0 1.8126038981895423 0.786157410502564 27.230691092799965 -6.695714143154582 1.8462512514597527 1.5066965910769075 0.7894520939161374 0.39726173313242163 0.34328576772753006 0.4044836941070646 2.6773819098490006 0.14851224619317457 0.3839540663776965 2.0150501390275959e-07 6.695714143154582 -0.7172444971607701 (ac)MDKNELVQK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MDKNELVQKAK 11 2 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 1 328127400.0 206918600.0 112874900.0 8333900.0 True False 267860206.67538714 106593312.58998848 6817215.713035169 1.0 0.3979438152198776 0.025450647551006993 27.996905029356245 -8.362475003369024 0.48074442637595444 1.052115049120462 8.0371800194174e-17 0.9943790781325527 0.030103127352722543 0.15747923614643958 0.15249196002725612 0.06927156650719088 0.0730769336098776 4.340352446359134e-09 8.362475003369024 -1.052115049120462 (ac)MDKSELVQK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MDKSELVQKAK 11 2 P31946-2 P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 64525790.0 23860900.0 23493400.0 17171490.0 True False 31281870.969284274 19988276.296555948 15394748.935363043 1.0 0.6389731712717079 0.4921300567500958 24.898823467054555 -13.999999999993552 0.12379825331225316 2.717030667734062 0.26931984121470515 0.9996745264764775 0.00384982237147252 11.950811890838366 0.10875643969508837 5.024841101895254 0.19781219110722495 1.0000000000148475e-14 13.999999999993552 -2.447710826519357 (ac)MDKSELVQK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MDKSELVQKAK 11 2 P31946-2 P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 418151300.0 146487200.0 117460900.0 154203200.0 True False 222231792.04882059 96499084.66879952 123724869.93033658 1.0 0.43422718135486343 0.5567379392015896 27.72748997974242 -9.820899040765733 6.486288016364717 1.0000000113471774 0.49548256027839954 0.9576489957267021 0.05001480745467663 8.229456285685327e-09 1.4462770319725827e-09 0.048426629805404 0.016142209694597478 1.5104312391176702e-10 9.820899040765733 -0.5045174510687779 (ac)MDKSELVQK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MDKSELVQKAK 11 2 P31946-2 P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 66177770.0 23860900.0 26779700.0 15537170.0 True False 32682919.54657686 25596484.305374503 11867610.444060575 1.0 0.7831761868426905 0.3631135347975228 24.962033528577447 -6.9606625571458585 0.42599334821584334 1.0174121957885718 0.11287486618697887 0.9997939878004733 0.0037947306373492307 0.07946529784517602 0.02026306286914161 0.005457877436586858 0.034911888314732575 1.0948066907024095e-07 6.9606625571458585 -0.9045373296015929 down (ac)MDKSELVQK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MDKSELVQKAK 11 2 P31946-2 P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 53713990.0 18611160.0 24026000.0 11076830.0 True False 15476004.154184012 23896567.1692124 13392943.939524716 1.0 1.5441044685137184 0.8654006425750325 23.883529685364277 -6.693254119297717 1.854504375471453 1.3400834241485668 0.8676337231941369 0.38568057980752946 0.2299705516978741 0.4098093043487691 2.734970852658093 0.09910262909854586 0.2570497229398258 2.0264966059318418e-07 6.693254119297717 -0.47244970095442995 (ac)MDKSELVQK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MDKSELVQKAK 11 2 P31946-2 P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 397694300.0 146487200.0 118669300.0 132537800.0 True False 189630568.09440455 112065249.13630168 108417280.35266961 1.0 0.5909661625888912 0.5717289224103141 27.49861630183487 (ac)MDLAAAAEPGAGSQHLEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MDLAAAAEPGAGSQHLEVR 19 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 10624700.0 1179000.0 5363200.0 4082500.0 False True 1545680.4174522427 4563031.465589863 3660082.0621052417 1.0 2.9521183124718267 2.3679423125112655 20.559810629972723 -10.169985595098478 5.112543454413161 0.9999052427825446 2.6600303124930993 0.9150145375108553 0.23848885331937333 0.00025760944390239955 4.1822325521953746e-05 0.23092872727761432 0.07697194642938636 6.761054004298342e-11 10.169985595098478 1.6601250697105547 (ac)MDLAAAAEPGAGSQHLEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDLAAAAEPGAGSQHLEVR 19 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 15565200.0 4037700.0 1898000.0 9629500.0 False True 3909525.423625234 2655881.2979392423 7107245.071192254 1.0 0.6793359833113684 1.8179303882366957 21.8985620590725 -6.8314910646168645 1.3211580738658344 0.8288255317825792 1.8495297001707 0.908838429702435 0.1447385938727156 0.17897772183631883 0.6104294037800454 0.08600246236116704 0.1979194504693155 1.4740388682450523e-07 6.8314910646168645 1.0207041683881208 (ac)MDLAAAAEPGAGSQHLEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MDLAAAAEPGAGSQHLEVR 19 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 11960800.0 1179000.0 4279800.0 6502000.0 False True 1614908.1612769922 4090704.284593994 4966361.512893398 1.0 2.533087876253756 3.0753213290879877 20.623020691495615 -9.716292503647963 0.2814098427803997 9.35911886066486e-15 3.3157729947989214 0.9988882316197711 0.029303532653736076 1.1070263930990683 0.11912788693133956 1.1628652836914175 0.20709057552684845 1.9217969347503388e-10 9.716292503647963 3.315772994798912 (ac)MDSSSSSSAAGLGAVDPQLQHFIEVETQK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDSSSSSSAAGLGAVDPQLQHFIEVETQKQR 31 1 O60220;A0A2R8YDA8 O60220 TIMM8A Mitochondrial import inner membrane translocase subunit Tim8 A 1 17336600.0 8520700.0 2625400.0 6190500.0 True False 8250215.042495382 3673735.9112801366 4569022.3389808 1.0 0.4452897157658776 0.5538064541889615 22.97600029313092 -9.951126302153824 6.169683137834625 1.0000001691001472 0.4995480849775794 0.9659373082303557 0.044301772948125435 1.0306106761616769e-07 1.7508582970785083e-08 0.04289502190981825 0.014298335736268517 1.119112374246126e-10 9.951126302153824 -0.5004520841225678 (ac)MDTQK(ub)DVQPPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MDTQKDVQPPK 11 1 E5RGX2;P53803 E5RGX2 POLR2K DNA-directed RNA polymerases I, II, and III subunit RPABC4 1 12431300.0 3348700.0 3074400.0 6008200.0 True False 5080222.722762708 2525749.29960316 4820676.6365123885 1.0 0.4971729464312967 0.9489104906587297 22.276460317105396 -10.37392150179245 8.581860945499987 1.0000011735341798 0.7230417185450134 0.33385805309413774 0.18442108016919323 4.1409657863302065e-06 3.019934244153418e-07 0.1785657012873072 0.05952164768207234 4.227450180162339e-11 10.37392150179245 -0.2769594549891664 (ac)MDTQK(ub)DVQPPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MDTQKDVQPPK 11 1 E5RGX2;P53803 E5RGX2 POLR2K DNA-directed RNA polymerases I, II, and III subunit RPABC4 1 17018000.0 3348700.0 4789900.0 8879400.0 True False 4334958.162745498 4523337.854339504 7263440.31033784 1.0 1.0434559422540532 1.6755502677648957 22.047586639197846 -6.92080501606371 0.8187341691624849 0.9864539845406475 1.7793928017004925 0.9944016553576963 0.023099443777709026 0.09770033453911875 0.10317672118647903 0.019987858502419773 0.060341746711549606 1.200037959789561e-07 6.92080501606371 0.792938817159845 (ac)MDWVMK(ub)HNGPNDASDGTVR ddPTM_RPMI8226_Bortezomib_1h_R1 2 MDWVMKHNGPNDASDGTVR 19 1 P31942-2;P31942 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 42613200.0 10224200.0 17304600.0 15084400.0 True False 13404025.211293645 14722821.13280248 13523610.987782072 1.0 1.0983880514039674 1.0089216317190801 23.6761629693979 -10.856415971659809 4.032977696307901 0.9858571240226167 1.0536548415615508 0.3241201052893571 0.03652451289036134 0.005783177748892095 0.00020589545085407333 0.0440338952191849 0.011788235846047511 1.3918230620659112e-11 10.856415971659809 0.06779771753893404 (ac)MDWVMK(ub)HNGPNDASDGTVR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MDWVMKHNGPNDASDGTVR 19 1 P31942-2;P31942 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 51705700.0 19318400.0 15027300.0 17360000.0 True False 18705147.96635751 21027779.25633427 12812895.21116335 1.0 1.1241706985774276 0.6849929887862004 24.156932042529352 -6.831177973894507 1.3225494256578842 1.0662980677222855 0.6728809543974402 0.9082221935357464 0.0559999553584968 0.1793653812041085 0.6131526579156338 0.03324058092617487 0.07649784079500035 1.4751019125800465e-07 6.831177973894507 -0.3934171133248453 (ac)MDWVMK(ub)HNGPNDASDGTVR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MDWVMKHNGPNDASDGTVR 19 1 P31942-2;P31942 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 212887100.0 25090400.0 45125700.0 142671000.0 True False 38063971.153941914 37072666.26629661 114472014.31507938 1.0 0.9739568716139424 3.007358687093389 25.18192274776858 -6.904001950392586 0.9356455910853742 0.9244887806574771 3.2390090903238886 0.9884536489224987 0.10234727763302524 0.10851842030731862 0.16128224065892677 0.0813835287012448 0.2163245918561465 1.2473779123248976e-07 6.904001950392586 2.3145203096664115 up (ac)MDWVMK(ub)HNGPNDASDGTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MDWVMKHNGPNDASDGTVR 19 1 P31942-2;P31942 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 37114100.0 10224200.0 15215200.0 11674700.0 True False 14004363.038615955 14542942.154062027 8917376.307993917 1.0 1.038457951565593 0.6367570080413466 23.73937303092079 -6.883421603881845 1.0605623537565296 1.0251088641602177 0.6063563254900565 0.9763410008530465 0.02783760825605541 0.12464105934581492 0.2543529681945596 0.020153528800867297 0.04918767118941627 1.3079116136200404e-07 6.883421603881845 -0.41875253867016127 (ac)MDWVMK(ub)HNGPNDASDGTVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MDWVMKHNGPNDASDGTVR 19 1 P31942-2;P31942 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 36615900.0 15659000.0 14962000.0 5994900.0 True False 13021152.311321128 14881396.736275513 7248405.872714186 1.0 1.1428632720421381 0.5566639341444553 23.63435379015499 -6.842305311994293 1.2717877479104973 1.0759885610101851 0.5365042611472138 0.9283216672165062 0.0668180793221672 0.16612616942729516 0.5209745441547319 0.0411823294926571 0.09493525094583942 1.4377874484614338e-07 6.842305311994293 -0.5394842998629713 (ac)MDWVMK(ub)HNGPNDASDGTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 3 MDWVMKHNGPNDASDGTVR 19 1 P31942-2;P31942 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 272173500.0 31661100.0 45262400.0 195250000.0 True False 40985918.083585106 42743507.65115265 159716503.43418026 1.0 1.0428827668074478 3.8968628958965996 25.288624978804638 -6.910168163276607 0.8945774133484092 0.9121041577685213 4.267035906381583 0.9909851320327588 0.12870966647330437 0.10430723172830465 0.1381605876147233 0.10546398071535978 0.2914729028221628 1.229792490345556e-07 6.910168163276607 3.354931748613062 up (ac)MDYLTTFTEK(ub)SGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDYLTTFTEKSGR 13 1 Q8N573-2;E5RFD1;C9JY63 Q8N573-2 OXR1 Oxidation resistance protein 1 1 7274100.0 2472700.0 3108500.0 1692900.0 True False 2394205.4919875483 4349740.260613349 1249478.7040886197 1.0 1.8167781651032864 0.5218761331348236 21.19111555182635 -6.736246336336522 1.7006924526054974 1.4880869467028408 0.5217573827214034 0.5878758644412589 0.3432183386820137 0.324644823485402 1.8422418702484973 0.15975904979811723 0.3936229992541898 1.8354969351201545e-07 6.736246336336522 -0.9663295639814374 (ac)MEDSTILSDWTNSNK(ub)QK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MEDSTILSDWTNSNKQK 17 1 E9PMH5;E9PNM6 E9PMH5 BIRC2 1 5896300.0 2128500.0 1236300.0 2531500.0 True False 2790484.112423319 1051848.8590596553 2269564.663862686 1.0 0.37694135378760724 0.8133229118770167 21.412084001774666 -10.517507348679395 5.796788413602288 1.0006462573553014 0.5951321328323947 0.534388026370874 0.17815202507995875 0.0014902036996849704 0.00012403656371989867 0.17275737751749848 0.057498318852317126 3.037334696893497e-11 10.517507348679395 -0.4055141245229067 (ac)MEDSTILSDWTNSNK(ub)QK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MEDSTILSDWTNSNKQK 17 1 E9PMH5;E9PNM6 E9PMH5 BIRC2 1 42402800.0 6760800.0 12803000.0 22839000.0 True False 10256627.880686263 10518204.619704416 18324861.639310677 1.0 1.0255031909182077 1.7866361003324784 23.29005315154461 -6.91402204592001 0.8679008064750559 0.9793243159706627 1.8939543551115134 0.9923527736497249 0.03191527985080157 0.10181816921714464 0.12478658231217786 0.0266605932365109 0.07581675805902224 1.2189277214057368e-07 6.91402204592001 0.9146300391408507 (ac)MEDSTILSDWTNSNK(ub)QK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MEDSTILSDWTNSNKQK 17 1 E9PMH5;E9PNM6 E9PMH5 BIRC2 1 6660800.0 2128500.0 1455900.0 3076400.0 True False 2915463.970549679 1391573.5239825232 2349817.680446823 1.0 0.4773077417657668 0.8059841260887853 21.475294063297557 -10.652200711490812 5.158653068463563 1.0057562078550686 0.6416459339272961 0.613151243062907 0.13418157201571904 0.008983782765719326 0.0006056910142591937 0.13139243825975705 0.0433069161487338 2.2274055041312197e-11 10.652200711490812 -0.3641102739277725 (ac)MEDSTILSDWTNSNK(ub)QK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MEDSTILSDWTNSNKQK 17 1 E9PMH5;E9PNM6 E9PMH5 BIRC2 1 72291600.0 9795000.0 14223600.0 48273000.0 True False 12679820.588315487 13432044.156450717 39487809.32280768 1.0 1.0593244646401707 3.1142246097074806 23.59603099658328 -6.913072658094444 0.8745386334751812 0.9423909921870663 3.3980185846282565 0.9920305874676436 0.08775131922702273 0.102421331991858 0.12800149313293951 0.07295294579969536 0.20594271893977784 1.221595268414033e-07 6.913072658094444 2.45562759244119 up (ac)MEFVK(ub)CLGHPEEFYNLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MEFVKCLGHPEEFYNLVR 18 1 P37268;P37268-5;E9PJG4;E9PNM1;E9PQ90;E9PNJ2;E9PSH1 P37268 FDFT1 Squalene synthase 1 76011100.0 5466100.0 19812000.0 50733000.0 True False 8292473.325437689 16276393.808137475 40705600.31293614 1.0 1.9627912167300678 4.90874057901026 22.983371035599376 -6.951006042806438 0.5476872425933087 0.958688668298346 6.050691747290151 0.9992778891664059 0.04468269405280298 0.08308426109276669 0.03430977704320993 0.04864293726597979 0.24428670898335222 1.1194223076316988e-07 6.951006042806438 5.092003078991805 (ac)MEFVK(ub)CLGHPEEFYNLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MEFVKCLGHPEEFYNLVR 18 1 P37268;P37268-5;E9PJG4;E9PNM1;E9PQ90;E9PNJ2;E9PSH1 P37268 FDFT1 Squalene synthase 1 64342100.0 5466100.0 12050000.0 46826000.0 True False 7075974.202939388 11379406.907198705 38304148.47533388 1.0 1.6081752958443027 5.413268530490427 22.754497357691825 -6.9349549305919584 0.7049316086650174 0.9513811468635106 6.3031014972144765 0.9974256521424213 0.09908801248178999 0.09014530504614723 0.06566560219078345 0.09310132222301272 0.3354123242668701 1.1615691507568696e-07 6.9349549305919584 5.351720350350966 up (ac)MEGGFGSDFGGSGSGK(ub)LDPGLIMEQVK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MEGGFGSDFGGSGSGKLDPGLIMEQVK 27 1 Q9Y5L4 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 1 176786700.0 44422700.0 57680000.0 74684000.0 True False 67392483.63438673 47386553.344103076 59922674.664839946 1.0 0.70314300332336 0.8891596129611203 26.006084359059535 -10.459107641063312 5.614552005505982 1.000187257685064 0.7961513081422398 0.6155650785149813 0.07594096288250073 0.000178167632762943 1.7164317749973296e-05 0.0735966332984094 0.024509840378239885 3.474500343384008e-11 10.459107641063312 -0.2040359495428241 (ac)MEGGFGSDFGGSGSGK(ub)LDPGLIMEQVK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MEGGFGSDFGGSGSGKLDPGLIMEQVK 27 1 Q9Y5L4 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 1 143001300.0 44422700.0 35949000.0 62629600.0 True False 57506060.85232908 33948406.54828924 51231655.433963336 1.0 0.5903448444411104 0.8908914064818678 25.777210681151985 -9.903574548840437 6.657385011339814 1.0000000130200681 0.740618125461483 0.49826987664021605 0.12269762015795306 2.3773964300214344e-08 3.7227708293432733e-09 0.1188014669538632 0.03960048662424967 1.2486060966536535e-10 9.903574548840437 -0.25938188755858516 (ac)MEGVEEK(ub)KK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEGVEEKKK 9 2 P18124 P18124 RPL7 60S ribosomal protein L7 1 16226300.0 5411100.0 6432600.0 4382600.0 True False 5239327.592386394 9001170.725565856 3234665.5848182323 1.0 1.718001130268327 0.6173818162312916 22.32095023960289 -6.7306644366654735 1.7207158458486618 1.4317728620604804 0.6179498065085731 0.562353754780132 0.3018160259356566 0.33500994050156097 1.9435454648051051 0.1389784587096947 0.34461856020093456 1.8592404668055198e-07 6.7306644366654735 -0.8138230555519073 (ac)MEGVEEK(ub)KK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MEGVEEKKK 9 2 P18124 P18124 RPL7 60S ribosomal protein L7 1 14414900.0 5151600.0 5450400.0 3812900.0 True False 7056285.736755346 5209583.305937462 2912371.5491404547 1.0 0.7382897320613545 0.41273435597573105 22.75047755179747 -6.968180667896355 0.29845879081235904 1.0575063753423435 0.08333897673476386 0.9999645108723875 0.0014310569412207413 0.07689755121594494 0.011131836319091464 0.0054427855709423155 0.029245647928053262 1.0760174937838709e-07 6.968180667896355 -0.9741673986075796 down (ac)MEGVEEK(ub)KK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MEGVEEKKK 9 2 P18124 P18124 RPL7 60S ribosomal protein L7 1 17807900.0 5411100.0 10180000.0 2216800.0 True False 4499569.402374983 10125158.319428217 2680322.630674876 1.0 2.250250504878069 0.5956842513108335 22.101355515037167 -6.704639448806644 1.814615051942512 1.7728343850954464 0.6002156119128844 0.4394120356925605 0.5273170586662875 0.38599055508865393 2.4741541343056768 0.2315676188606761 0.5920798656957443 1.974060920998267e-07 6.704639448806644 -1.172618773182562 (ac)MEGVEEK(ub)KK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MEGVEEKKK 9 2 P18124 P18124 RPL7 60S ribosomal protein L7 1 81490300.0 30861000.0 34443100.0 16186200.0 True False 39950172.86125625 32526311.207081746 13240477.684437022 1.0 0.814171976678124 0.3314247908368292 25.25169840980628 -6.954634054008223 0.5054179968594288 1.0092301941071917 0.11535247520649826 0.9995165462800212 0.006195527819208719 0.0816766187196904 0.028661650605453507 0.007193806607868102 0.039831479707090084 1.1101098239997195e-07 6.954634054008223 -0.8938777189006935 down (ac)MEGVEEKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEGVEEKK 8 1 P18124 P18124 RPL7 60S ribosomal protein L7 1 3613800.0 1087800.0 1289100.0 1236900.0 True False 1053268.384431615 1803844.3525676918 912918.7837953881 1.0 1.71261606180377 0.8667484919221561 20.006441667181942 -6.683368711911778 1.890349434921002 1.4495173717721515 0.8699106989364374 0.3394619985874514 0.3018045003369503 0.4310558394863554 2.981044308645809 0.12798726453958997 0.3360548308545584 2.0731526830547083e-07 6.683368711911778 -0.5796066728357141 (ac)MEGVEEKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MEGVEEKK 8 1 P18124 P18124 RPL7 60S ribosomal protein L7 1 2989070.0 1288500.0 958970.0 741600.0 True False 1764893.270403224 916599.5345102831 566449.3537314277 1.0 0.5193512547650364 0.3209538861248031 20.75114951037547 -13.999999999999979 0.12152270023624587 3.288519169828881 0.010700240717098774 0.9996855040568459 0.0050557977809760485 11.958178177370522 0.10747886275440273 6.596245271120319 0.2753523336176541 1.000000000000049e-14 13.999999999999979 -3.2778189291117825 (ac)MEK(ub)DGLCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MEKDGLCR 8 1 Q00534 Q00534 CDK6 Cyclin-dependent kinase 6 1 5084100.0 1817900.0 2161000.0 1105200.0 True False 2490026.7569002905 2065519.874528631 844174.5223084873 1.0 0.829517140249486 0.33902226952748005 21.2477298143645 -6.952387051029447 0.5319913697052253 1.007626918945602 0.13856988890649338 0.99937554942412 0.007001585132651032 0.0825411253311531 0.03210309763714557 0.0077885681561278685 0.04057200842221587 1.115868322641489e-07 6.952387051029447 -0.8690570300391086 down (ac)MEK(ub)DGLCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MEKDGLCR 8 1 Q00534 Q00534 CDK6 Cyclin-dependent kinase 6 1 36637400.0 4490500.0 2658900.0 29488000.0 True False 5813040.77098834 2510929.877639055 24121486.572430808 1.0 0.4319477493036994 4.149547117029707 22.47086159657562 -6.867935137229765 1.145038599561214 0.6824453029726133 4.358822404727426 0.962574546303989 0.31632684065401023 0.13884601495053792 0.3415387747972873 0.21466568745497433 0.5064585719082845 1.3553918277801774e-07 6.867935137229765 3.6763771017548126 up (ac)MEK(ub)EETTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MEKEETTR 8 1 Q09666;E9PLK4;E9PQE3;E9PJZ0;E9PKR9;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 4193300.0 1151300.0 1627700.0 1414300.0 True False 1509365.4492050584 1384853.5047249063 1267961.8029235615 1.0 0.9175070924369382 0.8400628248058563 20.525510724376126 -6.971888757163671 0.20822115271633299 1.0414781795832313 0.7139341751218868 0.9999935948054371 0.00016517599598872028 0.0756946492441419 0.006792691718837116 0.002352189934915949 0.008058446464074965 1.0668693606565073e-07 6.971888757163671 -0.32754400446134446 (ac)MEK(ub)EETTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MEKEETTR 8 1 Q09666;E9PLK4;E9PQE3;E9PJZ0;E9PKR9;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 8783110.0 5499210.0 1538200.0 1745700.0 True False 8342703.616102927 1263696.1919885457 1400661.6298325108 1.0 0.15147322140863106 0.16789061367695965 22.99208356228192 -10.658663013929358 6.399909641496126 1.0054943690854083 0.1596819175428191 0.9997138075265031 0.006702372327419787 0.0005254212261197061 2.8023122036821098e-05 0.006489328167586293 0.0021631813670148557 2.19450707873902e-11 10.658663013929358 -0.8458124515425892 (ac)MEK(ub)EETTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MEKEETTR 8 1 Q09666;E9PLK4;E9PQE3;E9PJZ0;E9PKR9;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 4385200.0 1151300.0 1432700.0 1801200.0 True False 1576966.722712636 1369398.5766946638 1375793.656878436 1.0 0.8683750626893879 0.8724303671493143 20.588720785899017 -10.18941070694873 5.175764329365842 1.0000082637420984 0.8704027149192805 0.999266157520906 0.001655571113321867 1.5787979978511033e-07 2.472612867472902e-08 0.0016031020381731805 0.0005343332791610245 6.465309102249735e-11 10.18941070694873 -0.12960554882281794 (ac)MEK(ub)EETTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MEKEETTR 8 1 Q09666;E9PLK4;E9PQE3;E9PJZ0;E9PKR9;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 10292100.0 3267800.0 4535800.0 2488500.0 True False 2717320.488085779 4511364.745114192 3008833.844476016 1.0 1.6602254923165987 1.107279710902115 21.373753300251956 -10.257490165461602 4.047439000369433 0.999623444503506 1.3837526016328634 0.3910640627800638 0.2257391701009309 79792086.91772832 182.73711416465846 281929.85139979783 0.07727652221807876 5.527259242047269e-11 10.257490165461602 0.38412915712935736 (ac)MEK(ub)EETTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MEKEETTR 8 1 Q09666;E9PLK4;E9PQE3;E9PJZ0;E9PKR9;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 22639910.0 5499210.0 3781400.0 13359300.0 True False 7118835.750635064 3570961.7658822564 10928044.477993589 1.0 0.5016215981052372 1.535088722480879 22.76320988437437 -6.775563613916635 1.553027064822673 0.7161800273581119 1.5421829131008244 0.7514217864393538 0.21039910262228476 0.25752980376541573 1.2264812834879815 0.10673730849571646 0.2528186341771929 1.6766267314195003e-07 6.775563613916635 0.8260028857427125 (ac)MEK(ub)SNETNGYLDSAQAGPAAGPGAPGTAAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MEKSNETNGYLDSAQAGPAAGPGAPGTAAGR 31 1 P43007 P43007 SLC1A4 Neutral amino acid transporter A 1 7846500.0 4823200.0 3023300.0 0.0 True False 6323261.907935234 2572235.4247310976 0.0 1.0 0.40678932205909885 0.0 22.592237546143362 -8.253962046475557 0.540545063517921 1.0303791327384053 3.4813226692555976e-19 0.9916502863629149 0.03751985938023203 0.13961536230043534 0.1751628212368201 0.05704082340020244 0.07198971652447421 5.57234444201816e-09 8.253962046475557 -1.0303791327384053 (ac)MEK(ub)SNETNGYLDSAQAGPAAGPGAPGTAAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEKSNETNGYLDSAQAGPAAGPGAPGTAAGR 31 1 P43007 P43007 SLC1A4 Neutral amino acid transporter A 1 9522700.0 4721200.0 2932000.0 1869500.0 True False 4571328.090254228 4102762.890178013 1379821.8662021807 1.0 0.8974991094874234 0.3018426678111052 22.12418193611045 -6.936514965005762 0.6912221836571475 1.0072570528460945 0.15644375159457935 0.997670909888009 0.014855228381782859 0.08939305664941709 0.06212253250766545 0.014103780840057834 0.0521025452839077 1.1574041493423816e-07 6.936514965005762 -0.8508133012515151 down (ac)MEK(ub)TLETVPLER ddPTM_RPMI8226_Bortezomib_1h_R1 2 MEKTLETVPLER 12 1 P22626;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 39035200.0 13009600.0 14308200.0 11717400.0 True False 17055711.585145634 12173472.33292678 10504995.84923748 1.0 0.7137475485648483 0.6159224607425127 24.02375161141996 -13.999999999999998 0.14985779803283478 2.3838475152326137 0.5081192876582832 0.9995667142656065 0.003392248621484854 11.95720719940337 0.12191006300041454 4.818514662579065 0.09715438775170009 1.0000000000000041e-14 13.999999999999998 -1.8757282275743306 (ac)MEK(ub)TLETVPLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEKTLETVPLER 12 1 P22626;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 11495800.0 4244500.0 4188500.0 3062800.0 True False 4109760.6708218334 5860989.892738951 2260560.797969531 1.0 1.4261146480743665 0.5500468224388073 21.970622951291514 -6.774453120207037 1.5574988441653062 1.243015086047176 0.5442785526139583 0.7472713778004078 0.1798220348170854 0.2592878293237119 1.2418887503563005 0.09097472228125647 0.2156772023919005 1.6809193622731974e-07 6.774453120207037 -0.6987365334332177 (ac)MEK(ub)TLETVPLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MEKTLETVPLER 12 1 P22626;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 9902500.0 4386300.0 3646500.0 1869700.0 True False 6008033.645300473 3485385.572637045 1428115.3676802176 1.0 0.580120847918909 0.2377009604127799 22.518461461366144 -7.847866385665405 0.29398774461604743 1.1173897949648102 3.8221350438597956e-11 0.9994007284061894 0.007631458462617411 0.11494448667826065 0.04850391526754262 0.04638305954096926 0.08517188278269293 1.4194941737867083e-08 7.847866385665405 -1.1173897949265887 down (ac)MEK(ub)TLETVPLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MEKTLETVPLER 12 1 P22626;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 12170100.0 4244500.0 6054900.0 1870700.0 True False 3529489.81323217 6022281.051896455 2261854.7208604696 1.0 1.7062752325615818 0.6408446660989654 21.75102822672579 -6.727975258326667 1.7306816549387314 1.425988562134926 0.6417166696373893 0.5498365067564006 0.29695117991734943 0.34004025967716844 1.9944193607783987 0.13602550930460874 0.33830569107706876 1.8707887158042865e-07 6.727975258326667 -0.7842718924975367 (ac)MEK(ub)TLETVPLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MEKTLETVPLER 12 1 P22626;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 57300400.0 10079000.0 6883400.0 40338000.0 True False 13047464.18679243 6500332.739005107 32996897.90283208 1.0 0.49820659753833285 2.528989344629425 23.637266106207687 -6.84132968065887 1.2762321776737007 0.7330927008199991 2.5975496676526837 0.926713774674277 0.23381391671421187 0.16725020520548678 0.5285911673121289 0.14362656399377807 0.33100998436295376 1.4410210315457486e-07 6.84132968065887 1.8644569668326847 up (ac)MEK(ub)TQETVQR ddPTM_RPMI8226_Bortezomib_1h_R1 2 MEKTQETVQR 10 1 C9J6G3;C9J7M1;O95749;A0A2R8Y7P7;A0A2R8YE82 C9J6G3 GGPS1 Geranylgeranyl pyrophosphate synthase 1 18184380.0 4967800.0 8543300.0 4673280.0 True False 6512833.9082436375 7268672.941522566 4189733.8148671566 1.0 1.1160537860979722 0.6433042626135436 22.634854004533835 -6.841800789813663 1.2741560927674498 1.061727766787796 0.6272074021699907 0.9274814508706709 0.05417123800263721 0.16670814562166877 0.5249762908003734 0.033328720232350555 0.07681743133794856 1.4394587042572285e-07 6.841800789813663 -0.4345203646178053 (ac)MEK(ub)TQETVQR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MEKTQETVQR 10 1 C9J6G3;C9J7M1;O95749;A0A2R8Y7P7;A0A2R8YE82 C9J6G3 GGPS1 Geranylgeranyl pyrophosphate synthase 1 27882300.0 10210400.0 8946700.0 8725200.0 True False 9886276.440890381 12519163.966424145 6439808.369610741 1.0 1.2663174089128182 0.6513886606463086 23.236995817125518 -6.789016265672257 1.5003560835239047 1.1490377077497722 0.6450342999949982 0.7980760219753029 0.11314506192119997 0.2368311883827492 1.053236444099245 0.059362499365922895 0.13907673556584096 1.6254878750594679e-07 6.789016265672257 -0.504003407754774 (ac)MEK(ub)TQETVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MEKTQETVQR 10 1 C9J6G3;C9J7M1;O95749;A0A2R8Y7P7;A0A2R8YE82 C9J6G3 GGPS1 Geranylgeranyl pyrophosphate synthase 1 11563900.0 7768100.0 1990100.0 1805700.0 True False 11784775.624180416 1634951.1062777299 1448802.6035335732 1.0 0.13873417351477443 0.12293849706912274 23.490420954919788 (ac)MEK(ub)TQETVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MEKTQETVQR 10 1 C9J6G3;C9J7M1;O95749;A0A2R8Y7P7;A0A2R8YE82 C9J6G3 GGPS1 Geranylgeranyl pyrophosphate synthase 1 18973500.0 4967800.0 9267300.0 4738400.0 True False 6804529.909747106 8857840.043137047 3619287.510411272 1.0 1.3017563535797954 0.5318938351974685 22.698064066056727 -6.800361601739512 1.4542408332065866 1.1664122304360602 0.5211454729732717 0.83329680605176 0.1293191895308941 0.22022488715188876 0.9194082330656035 0.0699537824973681 0.1626651783368189 1.5835741298470514e-07 6.800361601739512 -0.6452667574627885 (ac)MEK(ub)TQETVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MEKTQETVQR 10 1 C9J6G3;C9J7M1;O95749;A0A2R8Y7P7;A0A2R8YE82 C9J6G3 GGPS1 Geranylgeranyl pyrophosphate synthase 1 25752300.0 7832400.0 15360000.0 2559900.0 True False 6512987.634152346 15277252.631278705 3095163.2543597124 1.0 2.3456597017271954 0.4752294074887404 22.634888056836093 -6.7136509229471395 1.7821971003419201 1.8241917972768966 0.47914331434568225 0.4823737368111758 0.5667435366814748 0.3678094057723423 2.279472648106673 0.2528526935389838 0.6395353903985748 1.9335218180257803e-07 6.7136509229471395 -1.3450484829312144 (ac)MEK(ub)TQETVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MEKTQETVQR 10 1 C9J6G3;C9J7M1;O95749;A0A2R8Y7P7;A0A2R8YE82 C9J6G3 GGPS1 Geranylgeranyl pyrophosphate synthase 1 14181600.0 7768100.0 5128400.0 1285100.0 True False 10055958.582143303 4843000.031774093 1051224.986239515 1.0 0.4816050098271057 0.10453752147569599 23.261547277012237 -8.157568911096408 0.394239952391995 1.0739788462662356 5.045275954784796e-18 0.9973033799039558 0.01906238208331667 0.09804692538353975 0.09688190118847653 0.060069725203862036 0.08318977905260608 6.957145543650495e-09 8.157568911096408 -1.0739788462662356 (ac)MELEEGK(ub)AGSGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MELEEGKAGSGLR 13 1 P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195-2 PSMC5 26S protease regulatory subunit 8 1 14433300.0 3246100.0 7339700.0 3847500.0 True False 4924571.021697974 6029873.189662156 3087039.9385808446 1.0 1.224446385907351 0.6268647411072253 22.231566626517825 -6.8049489104022065 1.4354452788585639 1.1230730070664703 0.6175549346101034 0.8462786617771259 0.09663274166139238 0.2137718350817629 0.8689929656838543 0.05294520283688524 0.12278892246927255 1.566935390641079e-07 6.8049489104022065 -0.5055180724563669 (ac)MELQDPK(ub)MNGALPSDAVGYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MELQDPKMNGALPSDAVGYR 20 1 Q8WUX1;C9JJU1;C9JMY2;C9JHH7;C9JWG4;C9JNK4 Q8WUX1 SLC38A5 Sodium-coupled neutral amino acid transporter 5 1 5935200.0 1495500.0 2672200.0 1767500.0 True False 1960614.9824426032 2273518.1761540193 1584616.0550571992 1.0 1.159594411199281 0.8082239854573735 20.902874822112313 -6.783202252768489 1.5231630073517217 1.089992293300943 0.8051451892166192 0.7786047158889463 0.06758963401210422 0.24564598050146627 1.1258021235313436 0.03494144011944468 0.08223724941418506 1.6473950140607675e-07 6.783202252768489 -0.2848471040843238 (ac)MELQDPK(ub)MNGALPSDAVGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MELQDPKMNGALPSDAVGYR 20 1 Q8WUX1;C9JJU1;C9JMY2;C9JHH7;C9JWG4;C9JNK4 Q8WUX1 SLC38A5 Sodium-coupled neutral amino acid transporter 5 1 6303800.0 1495500.0 2712600.0 2095700.0 True False 2048426.7643678896 2592748.362631357 1600738.8222963205 1.0 1.2657266580049962 0.7814479141460944 20.966084883635205 -6.757715635858154 1.6209185289632941 1.1547865895653409 0.7798668614573143 0.6816192225114538 0.11173235724887103 0.2867785131714563 1.4844646111971862 0.05439968081637728 0.131035429426677 1.74696564381248e-07 6.757715635858154 -0.37491972810802654 (ac)MENSDSNDK(ub)GSGDQSAAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MENSDSNDKGSGDQSAAQR 19 1 Q9NVW2 Q9NVW2 RLIM E3 ubiquitin-protein ligase RLIM 1 5034770.0 2895600.0 1648900.0 490270.0 True False 2803680.7629713085 2307314.3688999047 361853.5792152681 1.0 0.822959018506315 0.12906375932464573 21.418890657653538 -7.07551222569046 0.682851683168723 1.0014477696530333 2.7009693622400048e-17 0.9980065385673013 0.016780991069122304 0.07646824182429542 0.05732619989817816 0.016279922632939745 0.05057920369716621 8.40403348830606e-08 7.07551222569046 -1.0014477696530333 down (ac)MENSDSNDK(ub)GSGDQSAAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MENSDSNDKGSGDQSAAQR 19 1 Q9NVW2 Q9NVW2 RLIM E3 ubiquitin-protein ligase RLIM 1 18576450.0 8229400.0 8946400.0 1400650.0 True False 6843110.72423438 8898203.96747864 1693519.4391261102 1.0 1.300315649718526 0.24747801217487744 22.706220860259826 -6.83046846700227 1.3258025422860265 1.1604167082468888 0.21887174831852907 0.9068131275926469 0.13518291732490578 0.18023187647235622 0.61941737856131 0.08005342159307421 0.1842244566523152 1.4775137561429285e-07 6.83046846700227 -0.9415449599283597 down (ac)MESGAYGAAK(ub)AGGSFDLR ddPTM_RPMI8226_Bortezomib_1h_R1 2 MESGAYGAAKAGGSFDLR 18 1 K7ELD9;K7ENG9;O43760;O43760-2 K7ELD9 SYNGR2 Synaptogyrin-2 1 16440000.0 7009300.0 8001900.0 1428800.0 True False 9189260.178157747 6808047.711161904 1280961.4820173846 1.0 0.7408700569110205 0.13939767262898312 23.13151728499875 -7.213169627005041 0.5790243845240297 1.003170847154616 5.88990750783647e-26 0.9981361069571958 0.015563214273858745 0.08908519906845802 0.052345031134267556 0.015468929654218819 0.052995187622139894 6.121112662352242e-08 7.213169627005041 -1.003170847154616 down (ac)MESGAYGAAK(ub)AGGSFDLR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MESGAYGAAKAGGSFDLR 18 1 K7ELD9;K7ENG9;O43760;O43760-2 K7ELD9 SYNGR2 Synaptogyrin-2 1 32301000.0 10446200.0 11851800.0 10003000.0 True False 10114591.098960795 16584285.546320524 7382914.216432434 1.0 1.6396397426312614 0.7299271067113111 23.26993466167317 -6.717755547072236 1.7675736008614016 1.3900796816691219 0.7315372010529195 0.5018484736138829 0.26923902233024505 0.35968333348947323 2.195004058116399 0.12100812781945973 0.30455962318549096 1.9153337125746212e-07 6.717755547072236 -0.6585424806162024 (ac)MESGAYGAAK(ub)AGGSFDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MESGAYGAAKAGGSFDLR 18 1 K7ELD9;K7ENG9;O43760;O43760-2 K7ELD9 SYNGR2 Synaptogyrin-2 1 28966100.0 10466000.0 8924100.0 9576000.0 True False 15877687.167090042 7331524.63068845 7683299.402690094 1.0 0.46175016257308743 0.4839054530949194 23.920497440950598 -10.087936405168874 5.782136942420598 1.0000028072147462 0.47282780783398604 0.9986770713226661 0.009044859480450149 3.2732057051717264e-07 5.1627956211324235e-08 0.008757694175090907 0.002919215844687585 8.16701954320172e-11 10.087936405168874 -0.5271749993807602 (ac)MESGAYGAAK(ub)AGGSFDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MESGAYGAAKAGGSFDLR 18 1 K7ELD9;K7ENG9;O43760;O43760-2 K7ELD9 SYNGR2 Synaptogyrin-2 1 17866800.0 7009300.0 4591800.0 6265700.0 True False 9600827.629210178 4388919.092947967 4785870.706142136 1.0 0.45713966154280666 0.4984852234594124 23.194727346521642 -10.564951471004271 6.1244749487047105 1.0011307919342645 0.4778124425011095 0.9953201828625917 0.016879254970722127 0.00026111705936648704 1.8548284093188962e-05 0.016374478959734918 0.005447756116499624 2.723005565553369e-11 10.564951471004271 -0.523318349433155 (ac)MESGAYGAAK(ub)AGGSFDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MESGAYGAAKAGGSFDLR 18 1 K7ELD9;K7ENG9;O43760;O43760-2 K7ELD9 SYNGR2 Synaptogyrin-2 1 39053100.0 10446200.0 15301100.0 13305800.0 True False 8686478.145125678 15218669.937269453 16087981.260931887 1.0 1.7519954212754503 1.8520718054139675 23.050339937107445 -11.173922187652705 0.3597908204398685 9.00170862331073e-12 1.866606959153094 0.999454675022661 0.008880448523463598 3.168786013824409 0.18088423175235113 2.5861326964619247 0.028833560952428807 6.700046430940409e-12 11.173922187652705 1.8666069591440924 (ac)MESGAYGAAK(ub)AGGSFDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MESGAYGAAKAGGSFDLR 18 1 K7ELD9;K7ENG9;O43760;O43760-2 K7ELD9 SYNGR2 Synaptogyrin-2 1 28575500.0 10466000.0 10625000.0 7484500.0 True False 13548443.315702906 10033709.40987436 6122397.797455172 1.0 0.7405802405539165 0.4518893908910698 23.691623763043047 -6.969744545173401 0.2642200671338317 1.0769860981693626 0.10687101115170479 0.9999803192398361 0.0009931446604582563 0.07638570210738269 0.009326510833652558 0.005866170003672772 0.027069665545391905 1.0721497652338907e-07 6.969744545173401 -0.9701150870176578 down (ac)MESGK(ub)TASPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MESGKTASPK 10 1 D6RHW1;D6RIY1;D6RGK3;D6RIV9;D6RIE8;Q16594 D6RHW1 TAF9 Transcription initiation factor TFIID subunit 9 1 3383770.0 662790.0 714380.0 2006600.0 True False 641750.0942429033 999635.6594424847 1481011.2632903452 1.0 1.557671231231828 2.307769451966423 19.291652077101563 -6.967005673963575 0.3217751929618132 0.8993907909575237 2.990307315643128 0.9999487202193954 0.0038369809638892018 0.0772867813893347 0.01249410259903266 0.011289386976852072 0.06587765063795042 1.078932626116095e-07 6.967005673963575 2.0909165246856043 (ac)MESGK(ub)TASPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MESGKTASPK 10 1 D6RHW1;D6RIY1;D6RGK3;D6RIV9;D6RIE8;Q16594 D6RHW1 TAF9 Transcription initiation factor TFIID subunit 9 1 2169380.0 662790.0 1061000.0 445590.0 True False 551139.2515754859 1055284.1824079885 538760.8088246199 1.0 1.914732400915657 0.9775402628002251 19.07205735253584 -6.65176408188913 2.0028629598570244 1.592759253782317 0.9815269059551912 0.20103746594538396 0.3902528073327919 0.5041865504071227 3.8789404036763258 0.1579376712537879 0.43213120905024804 2.2296460120646157e-07 6.65176408188913 -0.6112323478271258 (ac)MESYHK(ub)PDQQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MESYHKPDQQK 11 1 P29401;P29401-2;E9PFF2;F8W888;F8WAX4 P29401 TKT Transketolase 1 5483400.0 1678000.0 2197700.0 1607700.0 True False 2199874.2497751135 1869811.7265675056 1441350.6261473596 1.0 0.8499630043665681 0.6551968260434452 21.06898962743278 -6.967547807661246 0.31123690890145567 1.0295704247127009 0.4693872455401078 0.9999564440503822 0.0009315918926585599 0.07710669246818416 0.01186409995044301 0.00306452261908822 0.017270923256289546 1.07758662512751e-07 6.967547807661246 -0.5601831791725931 (ac)MESYHK(ub)PDQQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MESYHKPDQQK 11 1 P29401;P29401-2;E9PFF2;F8W888;F8WAX4 P29401 TKT Transketolase 1 6284600.0 1678000.0 2872900.0 1733700.0 True False 2298401.946244943 2745965.7785901465 1324235.7666722988 1.0 1.1947282689507026 0.5761549970995254 21.132199688955673 -6.822083169276711 1.3628915823677428 1.104740354198826 0.5620432427303909 0.889100819137395 0.08599826133551476 0.19078479834652456 0.6957661905716461 0.049579002769323484 0.1142099703270753 1.5063185720246126e-07 6.822083169276711 -0.5426971114684352 (ac)MESYHKPDQQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MESYHKPDQQK 11 1 P29401;P29401-2;E9PFF2;F8W888;F8WAX4 P29401 TKT Transketolase 0 14288000.0 4139700.0 1547300.0 8601000.0 False True 4008287.4894572143 2165144.959062904 6348140.075530874 1.0 0.540167082515356 1.5837536833942298 21.934554557083796 -6.786928085954386 1.508501253440858 0.7419637860236219 1.5939443294736393 0.7912260386473544 0.19512335927601096 0.23997142525155662 1.0788047049044485 0.10182955296266108 0.23896077797611628 1.6333223844321876e-07 6.786928085954386 0.8519805434500174 (ac)MESYHKPDQQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MESYHKPDQQK 11 1 P29401;P29401-2;E9PFF2;F8W888;F8WAX4 P29401 TKT Transketolase 0 1888650.0 762590.0 527800.0 598260.0 False True 987187.7878962245 498427.46602651186 489382.8186659809 1.0 0.504896304571089 0.49573427129694797 19.91296502203341 (ac)METEQPEETFPNTETNGEFGK(ub)RPAEDMEEEQAFKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 METEQPEETFPNTETNGEFGKRPAEDMEEEQAFKR 35 3 P61978;P61978-2;S4R457;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 7111800.0 3279500.0 2569700.0 1262600.0 True False 2727049.5564836645 2555856.516054489 1526603.8223971932 1.0 0.9372240816005132 0.5598005429595638 21.37890948675506 -6.935792178453492 0.697614197772728 1.0046979786757397 0.4694972419651341 0.9975591043503205 0.009605014538537494 0.08973995584924917 0.06375171050326263 0.009074751318674069 0.033130710666228746 1.1593319948636341e-07 6.935792178453492 -0.5352007367106056 (ac)METEQPEETFPNTETNGEFGK(ub)RPAEDMEEEQAFKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 METEQPEETFPNTETNGEFGKRPAEDMEEEQAFKR 35 3 P61978;P61978-2;S4R457;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 43886500.0 4813500.0 16505000.0 22568000.0 True False 6231170.63827021 15586482.240938967 18460855.567234743 1.0 2.50137303979623 2.9626624977741787 22.571071794431298 -9.907764459928861 0.29809644665303975 7.325072065069194e-23 3.1306117021520676 0.9988647884261919 0.028231873901144552 1.3043948717989553 0.131329207705642 1.306748951023567 0.16498555103235726 1.2366179326474894e-10 9.907764459928861 3.1306117021520676 (ac)METSALK(ub)QQEQPAATK ddPTM_RPMI8226_Bortezomib_8h_R1 1 METSALKQQEQPAATK 16 1 P40937 P40937 RFC5 Replication factor C subunit 5 1 10267300.0 0.0 2998400.0 7268900.0 True False 0.0 2463312.093393873 5832198.728927945 0.0 (ac)METSALK(ub)QQEQPAATK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 METSALKQQEQPAATK 16 1 P40937 P40937 RFC5 Replication factor C subunit 5 1 2821190.0 0.0 1830000.0 991190.0 True False 0.0 1820141.4267734422 1198443.246255248 0.0 (ac)METSALK(ub)QQEQPAATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 METSALKQQEQPAATK 16 1 P40937 P40937 RFC5 Replication factor C subunit 5 1 9671200.0 0.0 0.0 9671200.0 True False 0.0 0.0 7911140.834891914 0.0 (ac)MEVK(ub)PPPGRPQPDSGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MEVKPPPGRPQPDSGR 16 2 P51991 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 11424100.0 2422400.0 3599200.0 5402500.0 True False 3135844.552642726 3398901.35604892 4419300.434331165 1.0 1.0838870674200045 1.4092855561372803 21.580422614526704 -6.94558139386643 0.6054217519956578 0.9963741733489219 1.513611313980763 0.9988072503971633 0.006096351262390934 0.08531020454593177 0.04369125380391846 0.006223962690884884 0.02739499334387871 1.133492383244764e-07 6.94558139386643 0.5172371406318411 (ac)MFYAHFVLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MFYAHFVLSK 10 0 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7 O60216 RAD21 Double-strand-break repair protein rad21 homolog 0 14907000.0 3904400.0 5023700.0 5978900.0 False True 5923260.2498744875 4127181.4846527465 4797167.794355041 1.0 0.6967753079463629 0.8098863787821399 22.497960044441534 -10.434457328185117 7.520017085603528 1.0000137791759995 0.7533308435716611 0.8637788977621411 0.04617740130124287 1.0668369150136137e-05 8.023305945921553e-07 0.04471357119931318 0.014903692184237528 3.67741524224918e-11 10.434457328185117 -0.2466829356043384 (ac)MFYAHFVLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MFYAHFVLSK 10 0 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7 O60216 RAD21 Double-strand-break repair protein rad21 homolog 0 11419800.0 3904400.0 2347200.0 5168200.0 False True 5054322.767230121 2216576.256645375 4227640.63021015 1.0 0.43855059495143933 0.8364405727351261 22.269086366533983 -10.527948623001368 5.6976384422695805 1.0007408584341024 0.6374955838432963 0.5253293803825444 0.16243790322289514 0.0015316682201938507 0.00012689923624146482 0.1575863055747871 0.052426607831260304 2.965182149561396e-11 10.527948623001368 -0.36324527459080613 (ac)MIK(ub)LFSLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MIKLFSLK 8 1 P61081 P61081 UBE2M NEDD8-conjugating enzyme Ubc12 1 8320560.0 1990160.0 2598900.0 3731500.0 True False 2609119.0327368537 2211154.250432855 3345400.1750754993 1.0 0.8474715881833299 1.282195305427027 21.315131333342258 -6.811909489790567 1.4065487251293132 0.9170585367281843 1.290132825364426 0.8647335440230007 0.06623366821218214 0.204213771888468 0.795912943737174 0.03702325039475729 0.08556840089166597 1.542021788306683e-07 6.811909489790567 0.3730742886362417 (ac)MIK(ub)LFSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MIKLFSLK 8 1 P61081 P61081 UBE2M NEDD8-conjugating enzyme Ubc12 1 4536300.0 1758600.0 1668100.0 1109600.0 True False 1702774.205608973 2334181.029026582 818962.4727135284 1.0 1.3708106578886043 0.4809577629352437 20.699455710127328 -6.793565241874549 1.4824791815510892 1.206290022814459 0.470597557529084 0.8125439960897113 0.1580125444032196 0.23007900334910433 0.9988825293897924 0.08388740172196171 0.1958673904484485 1.608550715258007e-07 6.793565241874549 -0.7356924652853751 down (ac)MIK(ub)LFSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MIKLFSLK 8 1 P61081 P61081 UBE2M NEDD8-conjugating enzyme Ubc12 1 6728600.0 1591700.0 1870800.0 3266100.0 True False 2180194.5040751365 1788141.8700916977 2494714.4474409577 1.0 0.8201753865305921 1.1442623319974123 21.05602541879751 -6.756088590309587 1.6270676495452225 0.8950407694052911 1.1452274240946365 0.6748258171558649 0.07559859770578516 0.2895501036077325 1.5098044760242757 0.03667523178541582 0.08848454398200753 1.7535227699874916e-07 6.756088590309587 0.2501866546893454 (ac)MIK(ub)LFSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MIKLFSLK 8 1 P61081 P61081 UBE2M NEDD8-conjugating enzyme Ubc12 1 5803100.0 1758600.0 2636100.0 1408400.0 True False 1462353.8191895636 2621898.806075118 1702889.9282941604 1.0 1.79293052862417 1.164485575206349 20.479860985561604 -10.130921977303327 4.443642101546823 0.999948029465061 1.4787080512251531 0.436191576059608 0.25656157807397445 28903106.45762918 65895315.19838865 10781.377478584398 0.08782785797635088 7.397381599653747e-11 10.130921977303327 0.47876002176009214 (ac)MIK(ub)LFSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MIKLFSLK 8 1 P61081 P61081 UBE2M NEDD8-conjugating enzyme Ubc12 1 6668200.0 1746400.0 2151800.0 2770000.0 True False 2260749.226690575 2032050.4384157779 2265888.422600155 1.0 0.8988393822831997 1.0022732268793488 21.10836953953176 -10.917539768389522 7.912599136672242 1.0110061688636538 0.9505563045772225 0.23352493885008674 0.04222669023248275 0.009653919550010992 0.00010060714790892527 0.048142900349980595 0.013628605669655425 1.2090944609721023e-11 10.917539768389522 -0.06044986428643129 (ac)MLEHLSSLPTQMDYK(ub)GQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLEHLSSLPTQMDYKGQK 18 1 A0A5F9YFS9 A0A5F9YFS9 1 42762500.0 2118800.0 4333700.0 36310000.0 True False 2777767.3184883893 3687128.8526302916 32552989.51011422 1.0 1.327371384957024 11.719120350162722 21.405494325402984 -6.913614401738795 0.870770547630793 0.7138562809875905 13.171269205119748 0.992215358049059 0.43918326653696477 0.10207578343268134 0.12616535548596283 0.36611935571933546 1.0378339720737761 1.22007238726118e-07 6.913614401738795 12.457412924132157 up (ac)MLEHLSSLPTQMDYK(ub)GQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLEHLSSLPTQMDYKGQK 18 1 A0A5F9YFS9 A0A5F9YFS9 1 46383300.0 2118800.0 3094500.0 41170000.0 True False 2902177.6184170395 2957774.757856942 31446493.922765438 1.0 1.0191570423143939 10.835482199024598 21.468704386925875 -6.907324853091175 0.9137545161159666 0.6697595931597279 12.034103464714267 0.9898724152204371 0.466143688493645 0.10621381463981847 0.14855772968104125 0.3766605013710791 1.0214614004436275 1.237870310819502e-07 6.907324853091175 11.364343871554539 up (ac)MLGPEGGEGFVVK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 2 MLGPEGGEGFVVKLR 15 1 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 12994720.0 2516820.0 4897000.0 5580900.0 True False 3299575.392919552 4166386.688356489 5003442.003772964 1.0 1.2627038913240165 1.5163896586541656 21.653848951994494 -6.971551712418006 0.2179603125109814 0.8799560255707196 1.90628399969018 0.99999208725488 0.0005930167939384041 0.0758023296234001 0.007200800799001925 0.007137896466441405 0.02582466768027449 1.0676976518157238e-07 6.971551712418006 1.0263279741194604 (ac)MLGPEGGEGFVVK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MLGPEGGEGFVVKLR 15 1 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 49164200.0 13620400.0 18159500.0 17384300.0 True False 13188027.857430037 25410683.050541464 12830830.312178966 1.0 1.9267993156554695 0.9729150143514574 23.652725503779678 -6.6527783349245375 1.9986605402106437 1.600099574239944 0.9769411636040007 0.20524072285641104 0.3953050514924595 0.501860936336589 3.8457986407887166 0.16023163310414104 0.4379091136099317 2.2244449636664883e-07 6.6527783349245375 -0.6231584106359432 (ac)MLGPEGGEGFVVK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLGPEGGEGFVVKLR 15 1 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 87760000.0 16307000.0 20026000.0 51427000.0 True False 24738911.201389037 16452203.836147832 41262430.908745214 1.0 0.6650334649822452 1.6679162058849388 24.560278670632414 -6.816652457942751 1.3863547063242048 0.8188246487967327 1.6882681193431146 0.8765040862978305 0.14649934754107533 0.19786248201923132 0.7481385933939175 0.08306018935434478 0.19162674765863266 1.525272857763458e-07 6.816652457942751 0.8694434705463819 (ac)MLGPEGGEGFVVK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MLGPEGGEGFVVKLR 15 1 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 16554220.0 2516820.0 5239300.0 8798100.0 True False 3447356.368503102 5007810.4019518 6720169.982557268 1.0 1.4526523708734738 1.9493691003217268 21.717059013517385 -6.9699319497406105 0.25980557651017144 0.8602149475508634 2.556539638657627 0.9999818472334115 0.0016519013319772392 0.07632479295529601 0.009109085889447763 0.010382117878651004 0.04687967943725857 1.0716872163733678e-07 6.9699319497406105 1.6963246911067638 (ac)MLGPEGGEGFVVK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MLGPEGGEGFVVKLR 15 1 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 39446500.0 13620400.0 12395100.0 13431000.0 True False 11325966.086028395 12328325.136065288 16239360.002072489 1.0 1.0885009757598862 1.4338167604179224 23.433130779213954 -6.945446511559803 0.606787684963397 0.9961613153133616 1.5440402616448659 0.9987936817243271 0.006500585895177354 0.0853675196162722 0.043939640064548 0.006627951143897381 0.029085374226165663 1.1338444757024399e-07 6.945446511559803 0.5478789463315042 (ac)MLGPEGGEGFVVK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MLGPEGGEGFVVKLR 15 1 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 103276700.0 24407400.0 24643300.0 54226000.0 True False 31595860.441781674 23271878.691798285 44357424.405745834 1.0 0.7365483441946105 1.4038998712340351 24.91323221909122 -6.799590772499965 1.4574757234090132 0.8545684212240255 1.4130319976131402 0.8310075088129193 0.11282237743580845 0.22133293264236453 0.9282438669202955 0.06089781004115603 0.14166807711413062 1.5863873112566552e-07 6.799590772499965 0.5584635763891147 (ac)MLSRLLK(ub)EHQAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLSRLLKEHQAK 12 2 P78537-2 P78537-2 BLOC1S1 Biogenesis of lysosome-related organelles complex 1 subunit 1 1 357501000.0 88691000.0 110580000.0 158230000.0 True False 134550731.18062133 90846135.03451644 126955771.14532723 1.0 0.6751812809739718 0.9435531864550137 27.00357499004594 -9.999767296185611 6.531127071180255 1.0000000559180195 0.8093672348867903 0.40218537357012807 0.10956237162117155 8.931532608952178e-08 1.3553995152715202e-08 0.10608334178016457 0.03536110338831447 1.0005359639114519e-10 9.999767296185611 -0.19063282103122925 (ac)MLSRLLK(ub)EHQAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MLSRLLKEHQAK 12 2 P78537-2 P78537-2 BLOC1S1 Biogenesis of lysosome-related organelles complex 1 subunit 1 1 274581000.0 88691000.0 85390000.0 100500000.0 True False 114812247.860979 80637971.4361573 82210031.21708132 1.0 0.7023464215577261 0.7160388612600439 26.77470131213839 -9.91683041435288 6.709187226559457 1.0000000157187539 0.7091926414131561 0.9983400648640052 0.005589915100767136 1.317507600965027e-09 2.1637824628341125e-10 0.005412412264942204 0.0018041373409962834 1.211070946733685e-10 9.91683041435288 -0.2908073743055978 (ac)MMCGAPSATQPATAETQHIADQVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MMCGAPSATQPATAETQHIADQVR 24 0 P04080;A0A1W2PS52 P04080 CSTB Cystatin-B 0 27134000.0 13625200.0 3357800.0 10151000.0 False True 13192675.484057419 4698587.050695672 7492148.576527606 1.0 0.35615118831457965 0.5679021352099073 23.65323383806249 -10.051542438325113 5.279669214429725 1.0000052871126421 0.46202666176135265 0.8959001526595418 0.08644696207735936 5.37991611987695e-06 9.667026850868557e-07 0.083702732701264 0.027900637037519428 8.880911897131122e-11 10.051542438325113 -0.5379786253512895 (ac)MMGHRPVLVLSQNTK ddPTM_RPMI8226_Bortezomib_1h_R1 3 MMGHRPVLVLSQNTK 15 1 P49368;P49368-2;E9PRC8;Q5SZX9;E9PM09 P49368 CCT3 T-complex protein 1 subunit gamma 0 228952000.0 57481300.0 73082500.0 98388200.0 False True 75358540.94970103 62178875.873353794 88207932.8702567 1.0 0.8251072153169187 1.1705100942590192 26.167267696770935 -6.769017621534784 1.577984133161667 0.8995640953999617 1.1723928892210174 0.7269139726361791 0.07369053680076626 0.2679984023153261 1.3168040040709157 0.036811228249413096 0.08771341743428375 1.70208944457281e-07 6.769017621534784 0.2728287938210556 (ac)MMGHRPVLVLSQNTK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MMGHRPVLVLSQNTK 15 1 P49368;P49368-2;E9PRC8;Q5SZX9;E9PM09 P49368 CCT3 T-complex protein 1 subunit gamma 0 134986900.0 16358100.0 90731100.0 27897700.0 False True 24816433.637299396 74539426.31968011 22383707.367003713 1.0 3.0036316825011657 0.9019711572641418 24.5647924652773 -6.656958796210283 1.9833887761884696 2.2928933397993485 0.9107121495165604 0.22291184019803745 0.8537173281084857 0.4916700802070324 3.714735682933737 0.3481222517268715 0.9462767291464769 2.2031354761275925e-07 6.656958796210283 -1.382181190282788 (ac)MMGHRPVLVLSQNTK ddPTM_RPMI8226_Carfilzomib_1h_R1 4 MMGHRPVLVLSQNTK 15 1 P49368;P49368-2;E9PRC8;Q5SZX9;E9PM09 P49368 CCT3 T-complex protein 1 subunit gamma 0 235702100.0 66877100.0 69410300.0 99414700.0 False True 91603371.15567207 66343523.43683221 75934995.37001581 1.0 0.7242476188358514 0.828954157603772 26.448897357076067 -10.500373132340426 6.893597362725605 1.000080325090724 0.7766008883229497 0.8585475853454929 0.042746265452391775 5.279055665381919e-05 3.826117996632751e-06 0.04140370833063339 0.013796297850806232 3.15956189616188e-11 10.500373132340426 -0.22347943676777426 (ac)MMGHRPVLVLSQNTK ddPTM_RPMI8226_Carfilzomib_2h_R1 3 MMGHRPVLVLSQNTK 15 1 P49368;P49368-2;E9PRC8;Q5SZX9;E9PM09 P49368 CCT3 T-complex protein 1 subunit gamma 0 100895000.0 46827500.0 26451100.0 27616400.0 False True 38939141.05999045 26308602.6741677 33390861.556193475 1.0 0.6756338727050019 0.8575140757406748 25.214717724896364 -10.140919434606579 5.132396460768705 1.0000090992776898 0.7665739752545744 0.6871257612665136 0.0742522819595134 7.73135426440846e-06 1.2941537386837135e-06 0.07189726411031255 0.023964820953783696 7.229038961072509e-11 10.140919434606579 -0.2334351240231154 (ac)MMGHRPVLVLSQNTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MMGHRPVLVLSQNTK 15 1 P49368;P49368-2;E9PRC8;Q5SZX9;E9PM09 P49368 CCT3 T-complex protein 1 subunit gamma 0 72350000.0 12351000.0 37208000.0 22791000.0 False True 15988612.97460795 35137342.09153931 18643271.855407953 1.0 2.1976479227649137 1.16603434488132 23.93054145347076 -6.609913864184669 2.1540139246249095 1.8002058533358 1.1697191498251083 0.05008368614057046 0.5163585526751026 0.6129249596171159 5.388858092073764 0.19796589325599914 0.5732707526140992 2.455195818770074e-07 6.609913864184669 -0.6304867035106918 (ac)MMLGTEGGEGFVVK(ub)VR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MMLGTEGGEGFVVKVR 16 1 P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;E7EN40;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;D6RDL0;D6RF17;D6R9D3;E5RJ94 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 3367200.0 1741500.0 0.0 1625700.0 True False 1686217.035748904 0.0 1199880.400045407 1.0 0.0 0.7115812345665817 20.685358809190713 -10.57916684647029 8.702404627726038 1.000140206020382 0.35579061937168827 0.5221730743016186 0.29050182253797213 0.0007904020954442226 3.8222271018948156e-05 0.2813361746321205 0.09375906006103904 2.6353187593183043e-11 10.57916684647029 -0.6443495866486937 (ac)MNAGSDPVVIVSAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MNAGSDPVVIVSAAR 15 0 Q9BWD1 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 2669070.0 951670.0 1717400.0 0.0 False True 1247648.5859853902 1461170.6143727684 0.0 1.0 1.171139558675281 0.0 20.25078020973572 -6.927149143095351 1.2455494390931419 1.091035618161459 2.644310836624694e-21 0.9627459969970689 0.09968925008079707 0.11841630686170686 0.3671184632328851 0.06600306609616031 0.12800965717076906 1.1826353516541938e-07 6.927149143095351 -1.091035618161459 down (ac)MNAGSDPVVIVSAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MNAGSDPVVIVSAAR 15 0 Q9BWD1 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 4991070.0 951670.0 2195600.0 1843800.0 False True 1303528.1169147363 2098591.1321217325 1408332.4142529764 1.0 1.6099316193415114 1.080400488473004 20.31399027125861 -10.150562430619363 4.744230643123797 0.9999677823004368 1.3451660539098274 0.36164058602044036 0.21618017893329966 7.367566141302174e-05 1.3191355310898724e-05 0.20933506793455986 0.06977185273114761 7.070295565947624e-11 10.150562430619363 0.34519827160939054 (ac)MNGDQNSDVYAQEK(ub)QDFVQHFSQIVR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MNGDQNSDVYAQEKQDFVQHFSQIVR 26 1 P14324;P14324-2;A0A087WVN4;A0A087X1D8;A0A087WTP2 P14324 FDPS Farnesyl pyrophosphate synthase 1 150656000.0 12545100.0 8190900.0 129920000.0 True False 12146862.667340556 11461569.08497923 95890054.483545 1.0 0.9435826681235242 7.894223974505447 23.534080402014443 -6.905070218283369 0.9286610308527777 0.7498268527311927 8.703824455859104 0.9889242618055738 0.3434390225147694 0.10776870495460157 0.15712115241966862 0.2744970563873733 0.7341873103389397 1.244313410468784e-07 6.905070218283369 7.953997603127911 up (ac)MNGDQNSDVYAQEK(ub)QDFVQHFSQIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MNGDQNSDVYAQEKQDFVQHFSQIVR 26 1 P14324;P14324-2;A0A087WVN4;A0A087X1D8;A0A087WTP2 P14324 FDPS Farnesyl pyrophosphate synthase 1 185510900.0 12545100.0 14554800.0 158411000.0 True False 10431806.492161362 14476390.403498396 191534007.69029143 1.0 1.387716539256763 18.360579045845355 23.31448567744872 -6.911821825249765 0.8832241597557431 0.5042781138135771 20.64180700127091 0.9915913681112315 0.7422100240668273 0.10322595769776817 0.13231916149649872 0.6131842090379823 1.7148419112195459 1.2251187164726334e-07 6.911821825249765 20.137528887457332 up (ac)MNHQQQQQQQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MNHQQQQQQQK 11 0 Q93009;H3BMF6 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 0 2343530.0 892410.0 395320.0 1055800.0 False True 864080.9330305369 553173.3375665663 779254.306678933 1.0 0.6401869505747062 0.901830230121967 19.720806921331878 -10.508614231537086 5.333646023761213 1.000548203041201 0.7710085903483355 0.5052715434565629 0.10681542158653172 0.0006979432166284713 6.430089730647774e-05 0.10366647609041217 0.0344745290768962 3.1001718497942953e-11 10.508614231537086 -0.2295396126928655 (ac)MNK(ub)YDYVLTGYTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MNKYDYVLTGYTR 13 1 O00764-3 O00764-3 PDXK Pyridoxal kinase 1 8435100.0 1755500.0 1941100.0 4738500.0 True False 1699772.6134121194 2716191.3527027746 3497344.6980470913 1.0 1.5979733590661274 2.0575367966580718 20.696910332484748 -6.974056237841437 0.12848545318434496 0.27204967699800164 3.3953413286431133 0.9999992589058665 0.0003726840337135797 0.07500698061443152 0.003852408783407659 0.029401788727775068 0.06327253735311818 1.0615580845776737e-07 6.974056237841437 3.1232916516451117 (ac)MNSIK(ub)NVPAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MNSIKNVPAR 10 1 O75146-2;O75146 O75146-2 HIP1R Huntingtin-interacting protein 1-related protein 1 5759800.0 1318200.0 1702500.0 2739100.0 True False 1276354.4625461993 2382317.12842021 2021647.5387613757 1.0 1.8665011940865752 1.5839232737341564 20.28359761186106 -10.017369674962282 5.113377355967049 0.9999931466184753 1.7252122339144789 0.8977712260632195 0.1153619529210246 9.013107721809359e-06 1.7320561636870204e-06 0.11169978511796168 0.0372329102020357 9.607940945359495e-11 10.017369674962282 0.7252190872960036 (ac)MQIFVK(ub)TLTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MQIFVKTLTGK 11 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 4798500.0 1013200.0 1069200.0 2716100.0 True False 1328315.0118427563 909679.5277089567 2435064.0266709253 1.0 0.6848371956942417 1.8331977015698924 20.341165893818097 -6.833561788925099 1.3120740559421469 0.8319742279960074 1.8663738755130184 0.9127829236102694 0.14307212583747927 0.17645912091503474 0.5928690966053362 0.08558601743457667 0.19694897937259984 1.4670273518315698e-07 6.833561788925099 1.034399647517011 (ac)MQNDAGEFVDLYVPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQNDAGEFVDLYVPR 15 0 P63220;Q8WVC2;Q9BYK1;Q9BYK2 P63220 RPS21 40S ribosomal protein S21 0 5877400.0 2289200.0 0.0 3588200.0 False True 2216530.599044726 0.0 2648342.7763073896 1.0 0.0 1.1948144444515065 21.079871848265597 -10.757163945530209 6.213626358469505 1.012473073193701 0.5974072222257533 0.13147734319792626 0.48778095436885777 0.08421360250728395 0.0032911665403440754 0.4718972882875604 0.15743062607231212 1.7491862487305012e-11 10.757163945530209 -0.4150658509679478 (ac)MQPASAK(ub)WYDR ddPTM_RPMI8226_Bortezomib_1h_R1 2 MQPASAKWYDR 11 1 Q15185-4;Q15185;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 34945000.0 8752700.0 14619600.0 11572700.0 True False 11474874.461267363 12438412.666754462 10375268.01717707 1.0 1.0839693897078748 0.9041726819929979 23.451975034399837 -6.7797526710731395 1.5372488038482277 1.0475617129702715 0.9027700107037758 0.7663662908677619 0.0355049141931897 0.2509647944904871 1.1714660036755928 0.01819307390886805 0.04292946762253563 1.6605323045514704e-07 6.7797526710731395 -0.14479170226649563 (ac)MQPASAK(ub)WYDR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MQPASAKWYDR 11 1 Q15185-4;Q15185;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 46231600.0 10649500.0 18556300.0 17025800.0 True False 10311437.45174157 25965927.359826162 12566232.216948435 1.0 2.518167566971043 1.2186692956980538 23.297742127853002 -6.608323566056642 2.1601089033359724 2.0154576227917156 1.2232723207436285 0.04510058290056651 0.6548178520323277 0.6173409966312714 5.456183621615901 0.2505581712274838 0.7270939929406792 2.464202727542216e-07 6.608323566056642 -0.7921853020480871 (ac)MQPASAK(ub)WYDR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MQPASAKWYDR 11 1 Q15185-4;Q15185;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 90553000.0 13729600.0 20803400.0 56020000.0 True False 20828806.968209416 17090870.73229392 44947622.44556177 1.0 0.820540070220026 2.157954726555602 24.31207687131262 -6.87306673792852 1.1177982901936063 0.8963641547006969 2.2409657977837063 0.9676466291941165 0.10661094517192157 0.13394572503806804 0.3109449397357767 0.0738751461862066 0.17588852072438027 1.3394708354487926e-07 6.87306673792852 1.3446016430830094 up (ac)MQPASAK(ub)WYDR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MQPASAKWYDR 11 1 Q15185-4;Q15185;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 38030000.0 8752700.0 13848800.0 15428500.0 True False 11988809.722823666 13236914.224142581 11784606.059931688 1.0 1.1041057894965869 0.9829671445612131 23.515185095922728 -6.679211901713515 1.9042888059848193 1.0659128636131041 0.9834262332319763 0.3207361744944748 0.044129662386009495 0.44025292381419384 3.0858727301066677 0.018597897493922495 0.04910745868027358 2.093090942115128e-07 6.679211901713515 -0.0824866303811278 (ac)MQPASAK(ub)WYDR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MQPASAKWYDR 11 1 Q15185-4;Q15185;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 42028500.0 10649500.0 18694900.0 12684100.0 True False 8855531.102842731 18594186.8630529 15336286.665347887 1.0 2.0997257699297047 1.7318313816801745 23.07814740328728 -10.122579345427198 4.710223259834038 0.9999391587142668 1.9157785756561745 0.892029336507143 0.150192255160067 18649246.212759446 40078469.69332795 8180.343360789704 0.05141480394107189 7.540856121233492e-11 10.122579345427198 0.9158394169419077 (ac)MQPASAK(ub)WYDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MQPASAKWYDR 11 1 Q15185-4;Q15185;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 19431400.0 4727600.0 4687800.0 10016000.0 True False 6119971.394928055 4426919.809092621 8193190.772838684 1.0 0.7233562909724455 1.3387629196484179 22.545093479024473 -6.7844778275381215 1.5181526911391943 0.8442676386981091 1.3443637797342662 0.7829939031782849 0.11723539741870191 0.24368226156283754 1.1095074442302482 0.060802014063965126 0.14295623342914549 1.6425635169392633e-07 6.7844778275381215 0.5000961410361572 (ac)MQPASAK(ub)WYDRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MQPASAKWYDRR 12 2 Q15185-4;Q15185;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 56866100.0 5001100.0 11241000.0 40624000.0 True False 7587034.329384103 9234955.723666128 32594648.593868274 1.0 1.2172023115672126 4.296098736186189 22.855104634886228 -6.921131090768027 0.8162949977148187 0.9347940208752837 4.805747382061563 0.9944892655421038 0.11173860596960189 0.0975112204793545 0.10219987220069814 0.09685483667985983 0.29333847259069395 1.1991372917444947e-07 6.921131090768027 3.870953361186279 up (ac)MQPASAK(ub)WYDRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MQPASAKWYDRR 12 2 Q15185-4;Q15185;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 51724100.0 5001100.0 10387000.0 36336000.0 True False 6474022.536419054 9808954.31909317 29723220.838844437 1.0 1.5151251426626562 4.591151895384829 22.626230956978677 -6.935935649885433 0.696344233573319 0.96187851225965 5.330061018419139 0.9975816718847741 0.07796826156429208 0.08967060827135527 0.06342493003188912 0.07373515509775631 0.2698258383580056 1.1589490667878797e-07 6.935935649885433 4.3681825061594886 up (ac)MQSNK(ub)TFNLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MQSNKTFNLEK 11 1 Q15233;C9JYS8;C9IZL7;C9J4X2;C9JJ13 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 8956900.0 3904600.0 5052300.0 0.0 True False 5118968.412200187 4298516.5337111475 0.0 1.0 0.8397231995935679 0.0 22.287421673191513 -7.192237349100457 0.8991577583921272 0.9911599289047225 1.515804198368264e-19 0.9894174214262628 0.04511291704069065 0.09198316064887886 0.14126959857638605 0.03797453115601687 0.06666013892286422 6.423365738363989e-08 7.192237349100457 -0.9911599289047225 down (ac)MQSNK(ub)TFNLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQSNKTFNLEK 11 1 Q15233;C9JYS8;C9IZL7;C9J4X2;C9JJ13 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 21582400.0 8486800.0 5195400.0 7900200.0 True False 8217391.179439448 7269950.313653076 5830900.619080224 1.0 0.884702961670251 0.7095805094042001 22.97024901555856 -6.965049060437075 0.357219030033879 1.015577908506188 0.5727302510482535 0.9999141394936654 0.0011063459252951908 0.0779444369063736 0.014801928535604721 0.002363281251946052 0.014982925239712392 1.0838044742324332e-07 6.965049060437075 -0.44284765745793453 (ac)MQSNK(ub)TFNLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MQSNKTFNLEK 11 1 Q15233;C9JYS8;C9IZL7;C9J4X2;C9JJ13 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 21320300.0 3904600.0 6474700.0 10941000.0 True False 5348236.137847445 6188626.345030319 8356961.136968111 1.0 1.157134087860435 1.5625639783982341 22.350631734714405 -6.954781801171624 0.5036200039554041 0.9921291233699768 1.7451635059264987 0.9995250723090823 0.005165009948071395 0.0816205533189727 0.02844143075111514 0.006016771108808357 0.033449109052776656 1.1097322284085435e-07 6.954781801171624 0.7530343825565219 (ac)MQSNK(ub)TFNLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MQSNKTFNLEK 11 1 Q15233;C9JYS8;C9IZL7;C9J4X2;C9JJ13 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 73501000.0 10103000.0 29921000.0 33477000.0 True False 13078532.659903169 28255870.047327165 27384529.50302718 1.0 2.1604770796616544 2.0938533561172394 23.640697351604853 -10.290091917187274 5.709914408841991 0.9999003509442421 2.127165217889458 0.9973865905744248 0.02719902124138303 3.450606527977517e-05 4.290092035146451e-06 0.026337621656001772 0.008778446358412566 5.12752849829434e-11 10.290091917187274 1.1272648669452157 (ac)MTMDKSELVQK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MTMDKSELVQKAK 13 2 P31946;Q4VY19;A0A0J9YWE8;Q4VY20 P31946 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 28109500.0 8105600.0 10226000.0 9777900.0 True False 10492858.985262895 9656914.110623557 7998422.529726362 1.0 0.9203320204899911 0.7622729459111247 23.32290448625347 -6.960201969099646 0.43257895318804557 1.0061092889505283 0.6704085021305403 0.9997776110067128 0.0014732879554600912 0.07962906182597962 0.02086540302380947 0.0020663559379447676 0.013116127148330556 1.095968396370469e-07 6.960201969099646 -0.33570078681998805 (ac)MVPSSPAVEK(ub)QVPVEPGPDPELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVPSSPAVEKQVPVEPGPDPELR 23 1 P41440;H3BTQ3;P41440-3;C9J8K6;C9JKP4;E9PIL5 P41440 SLC19A1 Folate transporter 1 1 16611100.0 5928100.0 7267800.0 3415200.0 True False 7771796.507802063 6183472.569662506 3061827.864911651 1.0 0.7956297573482466 0.3939665509561269 22.889816696054403 -6.960385261644074 0.42997322655951103 1.0159592117946645 0.15823474429360532 0.9997842130039655 0.0036980423402174414 0.0795638328843149 0.020625239132626785 0.0052374532035492204 0.03335066596510456 1.0955059441419745e-07 6.960385261644074 -0.8577244675010592 down (ac)MVPSSPAVEK(ub)QVPVEPGPDPELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVPSSPAVEKQVPVEPGPDPELR 23 1 P41440;H3BTQ3;P41440-3;C9J8K6;C9JKP4;E9PIL5 P41440 SLC19A1 Folate transporter 1 1 15782000.0 5928100.0 5720200.0 4133700.0 True False 8119878.77087882 5467462.64982817 3157405.19622384 1.0 0.6733428914526052 0.38884880985509 22.953026757577295 -7.34222322948826 0.2180824633839136 1.1590964554977632 7.397769569314753e-11 0.9999613413051954 0.0015525223551442768 0.11238775115746683 0.015085194861887788 0.020108384943294606 0.051067827061896026 4.5475425415519717e-08 7.34222322948826 -1.1590964554237855 down (ac)MVPSSPAVEK(ub)QVPVEPGPDPELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVPSSPAVEKQVPVEPGPDPELR 23 1 P41440;H3BTQ3;P41440-3;C9J8K6;C9JKP4;E9PIL5 P41440 SLC19A1 Folate transporter 1 1 13386100.0 5782900.0 5152700.0 2450500.0 True False 4808737.575907716 5124941.382369134 2962888.2201681626 1.0 1.06575609533064 0.6161467897546637 22.197226766432603 -6.869737271600979 1.1354050997755616 1.0371353575214324 0.5899376111713931 0.9644243670127051 0.03739758822141732 0.13711121492846448 0.33051032416223225 0.02556505809556152 0.06050247042119302 1.3497791906409067e-07 6.869737271600979 -0.4471977463500393 (ac)MVYTQSEILQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVYTQSEILQK 11 0 A0A2R8YE10;Q9NRW7-2;B7Z7G7 A0A2R8YE10 VPS45 Vacuolar protein sorting-associated protein 45 0 25825900.0 7544200.0 11209000.0 7072700.0 False True 9890519.258136714 9536660.892339796 6340884.850129022 1.0 0.9642224683495958 0.6411073761281557 23.237614834643598 -6.927913162794646 0.7637285568025912 1.0053128025139273 0.5781665104313672 0.9961119263836149 0.010064810120167031 0.09373608167709813 0.0830958850957006 0.009058161813245274 0.029578957870455978 1.1805566644234283e-07 6.927913162794646 -0.42714629208256005 (ac)MVYTQSEILQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MVYTQSEILQK 11 0 A0A2R8YE10;Q9NRW7-2;B7Z7G7 A0A2R8YE10 VPS45 Vacuolar protein sorting-associated protein 45 0 35373600.0 13400000.0 8813600.0 13160000.0 False True 12974624.334789146 12332916.44231683 9713001.208462542 1.0 0.9505413123406055 0.7486152167364768 23.629189431836487 -6.944404714128107 0.6172283334672853 1.0022148619074116 0.6862947662651574 0.9986857480413077 0.0039420147417265385 0.08581344330363103 0.04588222857087674 0.003980009685618372 0.017071383162030628 1.1365676376039324e-07 6.944404714128107 -0.3159200956422542 (ac)MVYTQSEILQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVYTQSEILQK 11 0 A0A2R8YE10;Q9NRW7-2;B7Z7G7 A0A2R8YE10 VPS45 Vacuolar protein sorting-associated protein 45 0 28356300.0 7544200.0 11766000.0 9046100.0 False True 10333494.61433915 11246139.215041125 6909597.490277606 1.0 1.0883190667594247 0.6686602885232635 23.30082489616649 -6.851748300374962 1.2267008003342499 1.0472083896940034 0.6513168634808969 0.9428001250631407 0.04320440924846032 0.15554577043347348 0.4495518738066049 0.027547400866203768 0.0638186266815717 1.4068626489421236e-07 6.851748300374962 -0.3958915262131065 (ac)MVYTQSEILQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVYTQSEILQK 11 0 A0A2R8YE10;Q9NRW7-2;B7Z7G7 A0A2R8YE10 VPS45 Vacuolar protein sorting-associated protein 45 0 35071900.0 13400000.0 15777000.0 5894900.0 False True 11142693.720652854 15692006.169510696 7127496.335061951 1.0 1.4082776178641385 0.6396564882557275 23.409594707270763 -6.762420179849131 1.6036077516971314 1.2364384195912113 0.6365315138632525 0.7006782680656376 0.1717857553009924 0.2788689395406451 1.4139492208704252 0.08450500465639169 0.20257641197176424 1.7281435714763848e-07 6.762420179849131 -0.5999069057279588 (ac)MVYTQSEILQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVYTQSEILQK 11 0 A0A2R8YE10;Q9NRW7-2;B7Z7G7 A0A2R8YE10 VPS45 Vacuolar protein sorting-associated protein 45 0 28320100.0 8583700.0 6522400.0 13214000.0 False True 11111768.86002284 6159422.706349606 10809187.587089686 1.0 0.5543152295499554 0.9727692974228649 23.405585158927224 -10.569344507240787 9.308387868929309 1.000023176356549 0.7635422634864102 0.29861261680065687 0.1708331578467646 8.217432751445802e-05 3.8018210055131898e-06 0.16542466507337564 0.05513616461004519 2.6956002796777973e-11 10.569344507240787 -0.23648091287013884 (ac)RSFLQQDVNK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 RSFLQQDVNK 10 1 Q9H582-2;Q9H582 Q9H582-2 ZNF644 Zinc finger protein 644 1 644844000.0 83534000.0 170910000.0 390400000.0 True False 126727185.15342072 140409775.17407522 313237268.8816012 1.0 1.107968862435395 2.4717448628120664 26.91715079959227 -6.922667571769791 0.8046957113178536 0.972703521753939 2.7057502467324377 0.9948904179832226 0.04787753046718773 0.09662741975873251 0.09766678820090376 0.041845243668084335 0.1287293995793973 1.1949023857090599e-07 6.922667571769791 1.7330467249784987 up (ac)RSFLQQDVNK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RSFLQQDVNK 10 1 Q9H582-2;Q9H582 Q9H582-2 ZNF644 Zinc finger protein 644 1 465851000.0 72349000.0 87512000.0 305990000.0 True False 99098380.45820956 83645430.47651532 233721464.06186578 1.0 0.8440645557450775 2.358479149519781 26.562358144186348 -6.881505520337806 1.071416337172045 0.901300585197352 2.468930695561981 0.9748776028401964 0.10780146010793772 0.1263026059221329 0.26432497430799584 0.07740146591439866 0.1879055457812846 1.3136947964169232e-07 6.881505520337806 1.5676301103646293 up (ac)RSFLQQDVNK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RSFLQQDVNK 10 1 Q9H582-2;Q9H582 Q9H582-2 ZNF644 Zinc finger protein 644 1 607483000.0 91223000.0 85280000.0 430980000.0 True False 75855966.36411312 84820579.71324545 521095925.37362814 1.0 1.118179409990002 6.869544352943009 26.17675932267194 -6.911341632075115 0.886555396701568 0.8293937480132109 7.634526095890766 0.991417947354783 0.253785501335308 0.10353732738942788 0.1340067889983227 0.20916587625814395 0.582898202104628 1.2264740618065838e-07 6.911341632075115 6.805132347877555 up (ac)SAELNVPIDPSAPACPEPGHK(ub)GMDYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAELNVPIDPSAPACPEPGHKGMDYR 26 1 Q96SN7;C9JUY6;C9J5L2;C9J2H9;C9JQR7 Q96SN7 ORAI2 Protein orai-2 1 29741100.0 6205100.0 11516000.0 12020000.0 True False 8134946.190273878 9797857.68901642 10776285.703981634 1.0 1.2044157957345452 1.3246904714459864 22.955701372347757 -12.272176744109926 0.06796950670279944 5.084050761968377e-26 1.8197345300112466 0.9999550222550269 0.0008988578678616315 6.554635984538476 0.05459575603742776 1.3320131129784434 0.3826995510041152 5.34346852882304e-13 12.272176744109926 1.8197345300112466 (ac)SAELNVPIDPSAPACPEPGHK(ub)GMDYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAELNVPIDPSAPACPEPGHKGMDYR 26 1 Q96SN7;C9JUY6;C9J5L2;C9J2H9;C9JQR7 Q96SN7 ORAI2 Protein orai-2 1 13943100.0 5143100.0 2660000.0 6140000.0 True False 4979835.105690604 3722151.8717167457 4531749.803948327 1.0 0.747444803436028 0.9100200524249815 22.247666541308096 -10.691430598589378 5.6934203049247945 1.0029981947932256 0.828732427930505 0.5967290042973911 0.06637106747147718 0.002566169547365949 0.00013907988498298695 0.06528841608037292 0.02142116991558665 2.0350233720026536e-11 10.691430598589378 -0.17426576686272066 (ac)SAELNVPIDPSAPACPEPGHK(ub)GMDYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAELNVPIDPSAPACPEPGHKGMDYR 26 1 Q96SN7;C9JUY6;C9J5L2;C9J2H9;C9JQR7 Q96SN7 ORAI2 Protein orai-2 1 38076200.0 8844200.0 16363000.0 12869000.0 True False 13417297.997628288 13442894.805297479 10325436.509316929 1.0 1.0019077468260535 0.7695615399719159 23.677590832179888 -6.905047337410298 0.9287925273504364 1.0083684550214596 0.7425093483484158 0.9889147992303086 0.011484854727731007 0.10778525671109608 0.15720207784063847 0.009178374849259959 0.024546288741697297 1.2443789690434493e-07 6.905047337410298 -0.2658591066730438 (ac)SAELNVPIDPSAPACPEPGHK(ub)GMDYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAELNVPIDPSAPACPEPGHKGMDYR 26 1 Q96SN7;C9JUY6;C9J5L2;C9J2H9;C9JQR7 Q96SN7 ORAI2 Protein orai-2 1 24033400.0 6205100.0 4466300.0 13362000.0 True False 8499293.156522352 4268964.097920969 10206170.799028223 1.0 0.5022728383765618 1.2008258346985026 23.01891143387065 -6.715337581277933 1.7757667078260786 0.6957043034455114 1.1994890396035365 0.49063726984776135 0.20957249223110486 0.3644252306844468 2.2431218836619307 0.09379652402118926 0.23679439565100693 1.926027211700807e-07 6.715337581277933 0.5037847361580251 (ac)SAELNVPIDPSAPACPEPGHK(ub)GMDYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAELNVPIDPSAPACPEPGHKGMDYR 26 1 Q96SN7;C9JUY6;C9J5L2;C9J2H9;C9JQR7 Q96SN7 ORAI2 Protein orai-2 1 24399000.0 5143100.0 4789900.0 14466000.0 True False 4276715.52796192 4764095.857979291 17490773.716773152 1.0 1.1139613628334157 4.089767860970736 22.028071816742372 -6.914988133054747 0.8610826630573706 0.9217528561992366 4.518367941444176 0.9926715737511312 0.122453407435684 0.1012109625498156 0.12156138683270647 0.10279585446406296 0.29459528946455865 1.216219232958706e-07 6.914988133054747 3.59661508524494 up (ac)SAELNVPIDPSAPACPEPGHK(ub)GMDYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAELNVPIDPSAPACPEPGHKGMDYR 26 1 Q96SN7;C9JUY6;C9J5L2;C9J2H9;C9JQR7 Q96SN7 ORAI2 Protein orai-2 1 37313200.0 8844200.0 11555000.0 16914000.0 True False 11448991.245245516 10911954.09233865 13835825.552295672 1.0 0.9530930593444304 1.208475511590713 23.448717154272337 -6.859304141924002 1.189245477849888 0.9745953372293717 1.220678803356168 0.952785342446073 0.02411840891066563 0.14752519397254785 0.3968622150113239 0.015822015028940872 0.03690488860728125 1.3825977891175909e-07 6.859304141924002 0.2460834661267962 (ac)SAHLQWMVVR ddPTM_RPMI8226_Bortezomib_1h_R1 2 SAHLQWMVVR 10 0 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 139611600.0 38454300.0 50715800.0 50441500.0 False True 50413959.69197094 43149200.32864001 45222297.449034035 1.0 0.8558978622643693 0.8970193518886845 25.58731993741656 -9.133950287731878 9.220514396906477 1.0000000000116012 0.8764586061104714 0.9232801894423028 0.016787777842220786 0.0 0.0 0.016254695999892935 0.005418231999964311 7.345979503681347e-10 9.133950287731878 -0.12354139390112973 (ac)SAHLQWMVVR ddPTM_RPMI8226_Bortezomib_2h_R1 2 SAHLQWMVVR 10 0 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 122532400.0 47858700.0 25301300.0 49372400.0 False True 46339451.76502786 35404241.03453648 36440287.29974888 1.0 0.7640194194368065 0.7863771777992888 25.465737640210683 -9.959807674116655 5.089582696887297 1.0000011419700716 0.77519829861525 0.9926360840125416 0.009127516639817757 1.1827479174247585e-07 2.416726475318659e-08 0.008837724885781391 0.0029458933267911182 1.0969638754399138e-10 9.959807674116655 -0.2248028433548216 (ac)SAHLQWMVVR ddPTM_RPMI8226_Bortezomib_8h_R1 2 SAHLQWMVVR 10 0 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 221864100.0 62262200.0 92549200.0 67052700.0 False True 94456309.37653302 76033072.16980004 53799704.454757534 1.0 0.8049549328325748 0.5695723748881054 26.493143831415118 -6.968619212676846 0.28927288773386006 1.0463939794573383 0.3208683635340519 0.999969517884245 0.0009715701578813155 0.07675334414535223 0.010625827700297921 0.004128394728287391 0.02136355978974659 1.0749314940637784e-07 6.968619212676846 -0.7255256159232863 (ac)SAHLQWMVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SAHLQWMVVR 10 0 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 112708300.0 38454300.0 33193000.0 41061000.0 False True 52671893.8983832 31726423.5054275 31363237.477840018 1.0 0.6023406632507923 0.5954454103804825 25.65052999893945 (ac)SAHLQWMVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SAHLQWMVVR 10 0 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 88672900.0 47858700.0 16802600.0 24011600.0 False True 39796629.54989617 16712081.058745027 29032314.54290544 1.0 0.41993709637625903 0.729516918172815 25.24614291564496 -10.083659898360601 5.311084163863073 1.0000057797413124 0.5747270072741315 0.715594522251537 0.12638543301204108 8.649524216858296e-06 1.4923513002097157e-06 0.12237383080751597 0.04079072310468899 8.247837610296928e-11 10.083659898360601 -0.42527877246718093 (ac)SAHLQWMVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SAHLQWMVVR 10 0 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 232600800.0 62262200.0 116305900.0 54032700.0 False True 80599645.27144642 109833374.4238971 44199303.022320285 1.0 1.3627029505402444 0.5483808628867318 26.264270153507567 -6.785626552048651 1.51382530604055 1.2038715258186876 0.5407403758707985 0.7868320934698438 0.1537951968027797 0.2419289685365594 1.0953096055313505 0.0799889868200325 0.18788260855901615 1.638224618214418e-07 6.785626552048651 -0.6631311499478891 (ac)SAIQNLHSFDPFADASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAIQNLHSFDPFADASK 17 0 P41567;K7EM18 P41567 EIF1 Eukaryotic translation initiation factor 1 0 11084700.0 3546600.0 1911800.0 5626300.0 False True 3434015.1243106904 2675191.7099052966 4152603.244617994 1.0 0.7790273522578872 1.2092559567429237 21.711464962688677 -6.767063758578194 1.5854546929375095 0.8727857594361527 1.2114268466027345 0.7193298336017333 0.09306265949327017 0.2711832717215642 1.3447860122739745 0.04627767702848391 0.11047015496685464 1.7097642869355942e-07 6.767063758578194 0.3386410871665818 (ac)SAK(ub)AISEQTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAKAISEQTGK 11 1 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 1 8586700.0 2726900.0 2908000.0 2951800.0 True False 3574992.307337161 2474137.735295218 2646376.0516649713 1.0 0.6920679885708855 0.7402466422749113 21.769508706829615 -10.255678442344404 5.500150349537748 1.0000228663701947 0.7161573154229237 0.9788489997339603 0.019668853011564475 5.515523362821893e-06 7.463947460263316e-07 0.019045817632319186 0.006348095012725975 5.5503651758924405e-11 10.255678442344404 -0.28386555094727095 (ac)SAK(ub)AISEQTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAKAISEQTGK 11 1 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 1 17211200.0 3558300.0 5893600.0 7759300.0 True False 3445343.714214949 8246945.214717989 5726906.555989611 1.0 2.3936494871882834 1.6622163218030441 21.716216485507108 -10.038230971229332 4.865445752811033 0.9999811282612036 2.0279329045047274 0.7247766769774957 0.2986063394117799 6.965626289994324e-05 1.3769011129602829e-05 0.2891303764135241 0.09637478162666095 9.157333452961911e-11 10.038230971229332 1.027951776243524 (ac)SAK(ub)AISEQTGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAKAISEQTGK 11 1 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 1 30966700.0 7452200.0 4995500.0 18519000.0 True False 11305532.228796924 4104013.994980351 14858711.532833943 1.0 0.363009357890007 1.3142867785548855 23.430525575431613 -6.726272685524299 1.7368709032774847 0.615071565689906 1.3133389938347242 0.5418387822813433 0.26786414897613536 0.34329126122627124 2.0270910304484246 0.12230429386752195 0.30477306731189086 1.8781371986786138e-07 6.726272685524299 0.6982674281448182 (ac)SAK(ub)AISEQTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAKAISEQTGK 11 1 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 1 9182100.0 2726900.0 2975400.0 3479800.0 True False 3735108.62170163 2843936.9896679725 2657942.9087306093 1.0 0.7614067695767145 0.7116106057230838 21.832718768352507 -13.999999999999998 0.22022865297702438 2.4412190072006723 0.6850328170586921 0.9994981206159833 0.002819674294481634 13.005859102474682 0.14866491529044573 8.152754578426174 0.027516944350735085 1.0000000000000041e-14 13.999999999999998 -1.7561861901419802 (ac)SAK(ub)AISEQTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAKAISEQTGK 11 1 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 1 14045400.0 3558300.0 6214500.0 4272600.0 True False 2958884.1094178464 6181021.2550183255 5165980.905729638 1.0 2.088970377496274 1.7459220147510384 21.496621760941384 -10.18774491107829 4.884886965693818 0.9999011898524812 1.91744619612588 0.9050918690670834 0.1400489076448727 0.0001507260278371262 2.5062508020342006e-05 0.13561620227422458 0.045200590579163036 6.490155299404553e-11 10.18774491107829 0.9175450062733987 (ac)SAK(ub)AISEQTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAKAISEQTGK 11 1 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 1 31554000.0 7452200.0 6610800.0 17491000.0 True False 9647019.804823367 6242903.168639755 14307817.472815614 1.0 0.6471328239129763 1.4831334196766048 23.201651897524062 -6.792060750167476 1.4883560667831346 0.8033099851638497 1.4925030062533358 0.8078536961351732 0.15020948528214204 0.23229322573202277 1.016547033604866 0.07943361638792525 0.18567680905492726 1.6141327522220394e-07 6.792060750167476 0.6891930210894861 (ac)SASSLLEQRPKGQGNK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 SASSLLEQRPKGQGNK 16 2 Q9Y5A9;S4R3J8;S4R3V3 Q9Y5A9 YTHDF2 YTH domain-containing family protein 2 1 16762200.0 2523800.0 5218200.0 9020200.0 True False 3828789.1144947363 4286971.440017308 7237353.5163058955 1.0 1.1196676839129165 1.8902460542700765 21.86845676963991 -6.934358491271208 0.71010570209356 0.9899610150382164 2.0675613766483085 0.9973276645965006 0.0203933669080473 0.0904369280079979 0.0670508500185835 0.019087075161617645 0.06813054961134177 1.163165490326098e-07 6.934358491271208 1.077600361610092 (ac)SASSLLEQRPKGQGNK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SASSLLEQRPKGQGNK 16 2 Q9Y5A9;S4R3J8;S4R3V3 Q9Y5A9 YTHDF2 YTH domain-containing family protein 2 1 6896900.0 1415600.0 2456200.0 3025100.0 True False 1177134.121713149 2442967.963082474 3657634.423517943 1.0 2.0753522627711165 3.107236767714102 20.166847278576135 -6.971627816925881 0.21579518832836747 0.49813646191695526 4.71344892273699 0.9999924477326924 0.0023643180023652493 0.07577798765012052 0.007108990438111073 0.02952477767743469 0.10553996965006913 1.0675105679623332e-07 6.971627816925881 4.2153124608200345 (ac)SCINLPTVLPGSPSK(ub)TR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCINLPTVLPGSPSKTR 17 1 K7ES52;P04183;K7ERV3;K7ERJ1;K7ENW5 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 1 13752900.0 4902200.0 6103900.0 2746800.0 True False 6426831.672972328 5193221.912815852 2462587.4851661166 1.0 0.8080532021175612 0.3831728619130305 22.615676256145843 -6.9580134481581375 0.46258159993297904 1.012070335818342 0.16195364130960563 0.9996892755480005 0.004543175746881869 0.08041853910647953 0.023812232304649784 0.005796096550386395 0.035089928935272595 1.1015052003226882e-07 6.9580134481581375 -0.8501166945087364 down (ac)SCINLPTVLPGSPSK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SCINLPTVLPGSPSKTR 17 1 K7ES52;P04183;K7ERV3;K7ERJ1;K7ENW5 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 1 15567900.0 8030200.0 7537700.0 0.0 True False 7775285.696509255 10547542.918586228 0.0 1.0 1.356547312894443 0.0 22.890464256189862 -6.868005790317526 1.365832081759608 1.1873045946699996 9.479243429337653e-20 0.9179049514115956 0.16452100943287035 0.15854455046197408 0.5946749031816119 0.0973551602928721 0.20119845358874194 1.355171344139207e-07 6.868005790317526 -1.1873045946699996 down (ac)SCINLPTVLPGSPSK(ub)TR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCINLPTVLPGSPSKTR 17 1 K7ES52;P04183;K7ERV3;K7ERJ1;K7ENW5 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 1 16184000.0 4902200.0 6719300.0 4562500.0 True False 6714675.816973758 6422419.108246288 3484931.4676370486 1.0 0.956474933906908 0.5190021920086791 22.678886317668734 -6.926114023054859 0.7780376129126588 1.0076980306629495 0.4374794360947885 0.9957175650420793 0.014214525294066976 0.09470677024519401 0.08794057633831984 0.012662285341838015 0.04046257405014342 1.1854574680719142e-07 6.926114023054859 -0.570218594568161 (ac)SCINLPTVLPGSPSK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SCINLPTVLPGSPSKTR 17 1 K7ES52;P04183;K7ERV3;K7ERJ1;K7ENW5 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 1 16175400.0 8030200.0 4945800.0 3199400.0 True False 6677467.098178115 4919155.993735558 3868379.7476457995 1.0 0.7366799298910368 0.5793184287948422 22.670869531624138 -10.962525718407848 0.07779004014438644 1.9930561339645876 4.0174461004611305e-09 0.9999555896082772 0.001156535147892285 3.2958289405060395 0.047427111284330525 0.9515193804830644 0.36496716160875065 1.090119934854681e-11 10.962525718407848 -1.9930561299471414 (ac)SCINLPTVLPGSPSK(ub)TR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCINLPTVLPGSPSKTR 17 1 K7ES52;P04183;K7ERV3;K7ERJ1;K7ENW5 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 1 25777600.0 6190100.0 4292500.0 15295000.0 True False 8013206.47511299 4053618.601589248 12511466.939952843 1.0 0.5058672348177687 1.5613558665698086 22.933948220208272 -6.779364134746659 1.538069376826824 0.7199892818036666 1.5695973704614368 0.7652649861817988 0.20891050492100144 0.2515411383534027 1.1752736062311921 0.10697929587062759 0.2525900874907825 1.662018544498238e-07 6.779364134746659 0.8496080886577702 (ac)SDAAVDTSSEITTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDAAVDTSSEITTK 14 0 B8ZZQ6;P06454-2;P06454 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 159052000.0 31993000.0 65897000.0 61162000.0 False True 41943132.82065269 56065424.4644941 54833542.94733153 1.0 1.3367009256134446 1.3073306465160284 25.32193128759221 -10.086230967812018 4.439545428233111 0.9999719464439775 1.3220157860867838 0.9937995673457848 0.011990366304485786 1818669.2383472146 2069483.4111455868 402.3249833127728 0.004104621210842604 8.199153784687023e-11 10.086230967812018 0.32204383964280636 (ac)SDAAVDTSSEITTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDAAVDTSSEITTK 14 0 B8ZZQ6;P06454-2;P06454 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 77195500.0 29140000.0 5965500.0 42090000.0 False True 28214966.650429584 8347555.259671534 31065366.327065982 1.0 0.29585557775395915 1.1010243858145052 24.749957308555867 -6.675611127575642 1.9172194301684327 0.552742456484026 1.097882301587448 0.30425201329693685 0.29872270295456393 0.4483583935068831 3.1823049042090625 0.12519346119814315 0.3320893011047691 2.1105170861222245e-07 6.675611127575642 0.545139845103422 (ac)SDAAVDTSSEITTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDAAVDTSSEITTK 14 0 B8ZZQ6;P06454-2;P06454 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 54994300.0 2414300.0 52580000.0 0.0 False True 3662669.608972432 43196688.190584905 0.0 1.0 11.793771429660511 0.0 21.804464137966978 -6.666039391923622 1.9518824246327797 7.913411730654188 0.04924505303869475 0.26128156560065385 4.589287966146283 0.4703850157826657 3.451201062695111 1.895649116976695 5.09013272267401 2.1575487035845894e-07 6.666039391923622 -7.8641666776154935 (ac)SDAAVDTSSEITTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDAAVDTSSEITTK 14 0 B8ZZQ6;P06454-2;P06454 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 118359000.0 31993000.0 47242000.0 39124000.0 False True 43821676.67831614 45154692.23159722 29883716.9840728 1.0 1.0304190906036392 0.6819391508782656 25.385141349115102 -6.88563615752169 1.0478193915074174 1.0207293981037033 0.6544054140450551 0.9779562960471849 0.023398354974856712 0.12275665011514948 0.2430857411947101 0.017104256470243807 0.042024723873715114 1.3012592882528957e-07 6.88563615752169 -0.3663239840586482 (ac)SDAAVDTSSEITTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDAAVDTSSEITTK 14 0 B8ZZQ6;P06454-2;P06454 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 48847700.0 29140000.0 9590700.0 10117000.0 False True 24231201.120882448 9539032.9954951 12232417.92427722 1.0 0.3936673608504847 0.5048209481343178 24.530362583990144 -9.957095135165192 5.87918208735762 1.0000004069410664 0.4492441544929656 0.9703570400252125 0.04537826198825171 2.4207302872048593e-07 4.2985763880729896e-08 0.04393734597426282 0.014645771079925547 1.1038367904462481e-10 9.957095135165192 -0.5507562524481008 (ac)SDAAVDTSSEITTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDAAVDTSSEITTK 14 0 B8ZZQ6;P06454-2;P06454 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 20162300.0 2414300.0 11841000.0 5907000.0 False True 3125358.94296785 11182037.94092446 4831986.610938307 1.0 3.5778411839972417 1.5460581325579963 21.575590460059427 -6.586502109974837 2.2424049003338347 2.7485151618705386 1.551693575394498 0.0 1.1180543920286627 0.6797983166503841 6.439144367695501 0.41710016838367736 1.2471853619017428 2.5911818323350626e-07 6.586502109974837 -1.1968215864760405 (ac)SDAAVDTSSEITTK(ub)DLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDAAVDTSSEITTKDLK 17 1 B8ZZQ6;P06454-2;P06454 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 1 97331000.0 36606000.0 36282000.0 24443000.0 True False 47990820.49300831 30868867.02612828 21913872.833812222 1.0 0.6432244064388419 0.4566263424690731 25.516255143051747 -12.383258138823367 0.0965204975523305 2.3593771137368225 2.0657975824398375e-12 0.9998602469502945 0.0026649477226883423 6.662000967567682 0.07500485986572616 2.1671992526591177 0.3532535556136149 4.137536720754887e-13 12.383258138823367 -2.3593771137347566 (ac)SDAAVDTSSEITTK(ub)DLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDAAVDTSSEITTKDLK 17 1 B8ZZQ6;P06454-2;P06454 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 1 136571000.0 55570000.0 47885000.0 33116000.0 True False 53805960.76748014 67005730.216976166 24441926.141295254 1.0 1.245321694124898 0.4542605650500296 25.681262671441843 -6.823393750387632 1.3570047267478975 1.1317935724566193 0.4356816738779181 0.892041906609752 0.10863205255527593 0.18910285788243278 0.6832791085476284 0.06289047805318232 0.14484686048928433 1.5017797693935348e-07 6.823393750387632 -0.6961118985787011 down (ac)SDAAVDTSSEITTK(ub)DLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDAAVDTSSEITTKDLK 17 1 B8ZZQ6;P06454-2;P06454 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 1 213546200.0 86274000.0 77367200.0 49905000.0 True False 130883965.4742526 63560418.68730736 40041254.87586147 1.0 0.48562418212955905 0.30592941412474517 26.96371312339716 -13.999999999999998 0.14663209318068837 3.4752307891741947 0.10036420605785484 0.9995778671916676 0.006043133111691208 11.946670746702717 0.1204142758415908 8.434864761544887 0.18471358522259218 1.0000000000000041e-14 13.999999999999998 -3.37486658311634 (ac)SDAAVDTSSEITTK(ub)DLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDAAVDTSSEITTKDLK 17 1 B8ZZQ6;P06454-2;P06454 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 1 100819000.0 36606000.0 32710000.0 31503000.0 True False 50140227.439953834 31264764.04249489 24062640.22465098 1.0 0.6235465142222673 0.47990688222281297 25.57946520457464 -13.999999999999998 0.13352317561693816 2.7907022656931626 0.2874686051437571 0.999629968246533 0.0042185650617699464 11.932878310064378 0.11396696523811105 5.591472634653881 0.1713976948171135 1.0000000000000041e-14 13.999999999999998 -2.5032336605494057 (ac)SDAAVDTSSEITTK(ub)DLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDAAVDTSSEITTKDLK 17 1 B8ZZQ6;P06454-2;P06454 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 1 146193000.0 55570000.0 69514000.0 21109000.0 True False 46208917.16840896 69139514.28455125 25522794.303011555 1.0 1.4962374909710923 0.5523348277128725 25.46166794687612 -6.763859824734093 1.5980387707627224 1.2868518142642191 0.5482203946416555 0.7065189699266332 0.20884937980543034 0.2764634298939801 1.3922991873160226 0.10307813810691903 0.2467685487340102 1.722424424418801e-07 6.763859824734093 -0.7386314196225636 (ac)SDAAVDTSSEITTK(ub)DLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDAAVDTSSEITTKDLK 17 1 B8ZZQ6;P06454-2;P06454 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 1 254772000.0 86274000.0 123690000.0 44808000.0 True False 111683393.71478634 116806542.76775141 36653403.76890529 1.0 1.0458720753601778 0.32819027565109316 26.73483944548961 -6.891650829992336 1.0125419968681897 1.0370495549451928 0.2644232725525742 0.9819348703642016 0.044090906942701666 0.11781487693354553 0.2140940973969601 0.0331042728629081 0.0830373359130341 1.283361982871592e-07 6.891650829992336 -0.7726262823926187 down (ac)SDK(ub)PDMAEIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDKPDMAEIEK 11 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 10946100.0 5070600.0 3183400.0 2692100.0 True False 4909636.578506119 4454548.221211691 1986958.2487311568 1.0 0.907307119372795 0.4047057693495797 22.227184806533874 -6.938014402354343 0.6777858975824412 1.005882267440964 0.27673765006676226 0.9978920621546041 0.012007378238673228 0.08868432930623231 0.05882342612642495 0.011519381756199945 0.04364986418882825 1.1534150068928033e-07 6.938014402354343 -0.7291446173742018 down (ac)SDK(ub)PDMAEIEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDKPDMAEIEK 11 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 12046800.0 4666800.0 3985100.0 3394900.0 True False 6392242.075527948 3809025.1050365744 2593094.540160225 1.0 0.5958824869319391 0.40566275643527716 22.60789061378385 -13.999999999999996 0.10040532489789265 2.993399912526635 0.003048776732816957 0.9997916852239935 0.0035768047600557933 12.077363246296013 0.09444750219524337 4.983336088269699 0.3589959276474903 1.0000000000000082e-14 13.999999999999996 -2.990351135793818 (ac)SDK(ub)PDMAEIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDKPDMAEIEK 11 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 11623100.0 5070600.0 6552500.0 0.0 True False 4216428.565667351 6517200.3819305785 0.0 1.0 1.5456683969455736 0.0 22.00759008196815 -6.829767968064934 1.4534811610694833 1.2956892212022444 3.843172870365488e-21 0.8625103194704377 0.23732376208634612 0.19501966602325152 0.826230231648939 0.13062285770346865 0.28316182469670836 1.479898847392326e-07 6.829767968064934 -1.2956892212022444 down (ac)SDKPDMAEIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDKPDMAEIEK 11 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 0 106272700.0 36381000.0 7217700.0 62674000.0 False True 35226105.06895257 10099765.249808269 46257799.220302485 1.0 0.28671251703924416 1.3131681498637493 25.070141629866125 -6.719779459875588 1.7599570102111806 0.565967258344693 1.3115739683831535 0.5116682886908266 0.30015874792782693 0.35568258066196445 2.152950670107956 0.13542122233914183 0.34006561639448407 1.9064285802744692e-07 6.719779459875588 0.7456067100384606 (ac)SDKPDMAEIEK(ub)FDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDKPDMAEIEKFDK 14 2 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 27301500.0 9191400.0 11640000.0 6470100.0 True False 12050014.409644213 9903357.37236462 5800636.11758166 1.0 0.821854400807893 0.4813800150262998 23.522531535870908 -6.960923133797467 0.4222222081200089 1.0146943850515442 0.27564954571362876 0.9998029184917894 0.003020464506839106 0.0793729980240905 0.019924957956470427 0.0044109179745210145 0.028324782987595915 1.0941500038083469e-07 6.960923133797467 -0.7390448393379154 down (ac)SDKPDMAEIEK(ub)FDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDKPDMAEIEKFDK 14 2 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 42527000.0 15049000.0 13878000.0 13600000.0 True False 22830433.229269836 11401362.470691092 10911954.038908247 1.0 0.49939317209600453 0.47795650346742163 24.44445490054984 (ac)SDKPDMAEIEK(ub)FDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDKPDMAEIEKFDK 14 2 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 42485300.0 15049000.0 18089000.0 9347300.0 True False 19481227.160138838 17082331.24849106 7646187.311397254 1.0 0.8768611498686163 0.39249002378260656 24.21558122264229 -6.945260702515131 0.608666683070698 1.0053682996780617 0.23881645437682897 0.9987748094527997 0.009178508204768083 0.08544672333035419 0.04428347530803138 0.009341554112417697 0.040824269891582235 1.1343296848002364e-07 6.945260702515131 -0.7665518453012328 down (ac)SDKPDMAEIEKFDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDKPDMAEIEKFDK 14 2 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 0 58615200.0 17387000.0 5504200.0 35724000.0 False True 16835059.20216261 7702055.76402381 26366812.70297231 1.0 0.45750096103222576 1.5661847330828078 24.004965458766833 -6.773616547585785 1.560346063668489 0.6902870644499617 1.5733371652164947 0.7443286900939361 0.22887907908804297 0.2606007217532987 1.2525896527597853 0.11558144335293667 0.2742590672284319 1.6841604036026276e-07 6.773616547585785 0.883050100766533 (ac)SDQEAK(ub)PSTEDLGDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDQEAKPSTEDLGDKK 16 2 B8ZZJ0;B9A032;B8ZZN6;P63165 B8ZZJ0 SUMO1 Small ubiquitin-related modifier 1 1 7751600.0 2744000.0 2277900.0 2729700.0 True False 3597410.572933797 1938046.1991846566 2447256.829131337 1.0 0.5387336696473101 0.6802828811212186 21.77852739316577 -10.799836004379898 10.597673056479584 1.0029535154797253 0.6095082753842676 0.9102916128776805 0.05778722360073098 0.0040420970999979315 7.634519524029202e-05 0.05608418875827943 0.0186507462190996 1.5854917831242687e-11 10.799836004379898 -0.3934452400954578 (ac)SDQEAK(ub)PSTEDLGDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDQEAKPSTEDLGDKK 16 2 B8ZZJ0;B9A032;B8ZZN6;P63165 B8ZZJ0 SUMO1 Small ubiquitin-related modifier 1 1 14085600.0 3003900.0 2772100.0 8309600.0 True False 2908542.838751731 3879013.986310523 6133066.477343484 1.0 1.3336623186802683 2.108638867418447 21.471865122518587 -6.957018938387015 0.4755931407796572 0.9806046446543697 2.4937675124072376 0.9996431429652305 0.00877280498877653 0.08078378293583244 0.025200734311320316 0.010831173455860873 0.06394110572358236 1.104030475122035e-07 6.957018938387015 1.513162867752868 up (ac)SDQEAK(ub)PSTEDLGDKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDQEAKPSTEDLGDKK 16 2 B8ZZJ0;B9A032;B8ZZN6;P63165 B8ZZJ0 SUMO1 Small ubiquitin-related modifier 1 1 27026300.0 7262300.0 9761000.0 10003000.0 True False 11017440.04524728 8019073.286958903 8025902.665529357 1.0 0.7278526821135899 0.7284725519329315 23.393285709984156 -9.989494201583186 5.401442492023677 1.00000094649908 0.7281626170226935 0.9999960981713467 0.00025306079604746015 2.8843615429901843e-09 5.400956252553792e-10 0.0002450259119902046 8.167502043441403e-05 1.0244854584810685e-10 9.989494201583186 -0.27183832947638653 (ac)SDQEAK(ub)PSTEDLGDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDQEAKPSTEDLGDKK 16 2 B8ZZJ0;B9A032;B8ZZN6;P63165 B8ZZJ0 SUMO1 Small ubiquitin-related modifier 1 1 7775300.0 2744000.0 1968300.0 3063000.0 True False 3758530.9538117545 1881333.9977023143 2339582.4844651567 1.0 0.5005503535348935 0.6224725865547134 21.841737454688662 -10.032511152159312 7.324229338881984 1.0000000359623487 0.5615114700448428 0.945193587246189 0.04977454319987843 2.920543049371789e-08 3.922032189602036e-09 0.04819399781026713 0.016064664739850857 9.278736631430964e-11 10.032511152159312 -0.43848856591750585 (ac)SDQEAK(ub)PSTEDLGDKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDQEAKPSTEDLGDKK 16 2 B8ZZJ0;B9A032;B8ZZN6;P63165 B8ZZJ0 SUMO1 Small ubiquitin-related modifier 1 1 9863000.0 3003900.0 3800800.0 3058300.0 True False 2497875.945333521 3780324.336000267 3697776.390018485 1.0 1.5134155653576749 1.480368309293579 21.252270397952863 -10.160177677706889 4.91699828505727 0.999963115472432 1.4968919373270217 0.9966934897284023 0.013491485797537377 5.4557086767663495e-06 9.318062494358077e-07 0.013064042257905799 0.004354358316762782 6.915479882792273e-11 10.160177677706889 0.49692882185458975 (ac)SDQEAK(ub)PSTEDLGDKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDQEAKPSTEDLGDKK 16 2 B8ZZJ0;B9A032;B8ZZN6;P63165 B8ZZJ0 SUMO1 Small ubiquitin-related modifier 1 1 39907400.0 7262300.0 8553100.0 24092000.0 True False 9401190.511334725 8077112.466220844 19707503.20479529 1.0 0.8591584710981571 2.0962774002967564 23.164412032076605 -6.878585248523303 1.0876134356463796 0.9142307578836724 2.1816227053769093 0.972528258112901 0.09165492783971348 0.12889280624345653 0.27989614304918564 0.0649947267010374 0.15663020529220884 1.322558074987002e-07 6.878585248523303 1.267391947493237 up (ac)SDQEAKPSTEDLGDKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDQEAKPSTEDLGDKK 16 2 B8ZZJ0;B9A032;B8ZZN6;P63165 B8ZZJ0 SUMO1 Small ubiquitin-related modifier 1 1 12297600.0 4843800.0 3710900.0 3742900.0 True False 6350268.707425925 3157248.184974904 3355620.612432017 1.0 0.4971833997013162 0.5284218301672804 22.598386209188327 -9.926793046545745 5.1892048856009305 1.0000012492412973 0.5128026149286281 0.9969260781391159 0.01275303585451658 3745066.609806256 7164197.313203487 35.54347991057041 0.004365704744025972 1.1836054424223363e-10 9.926793046545745 -0.4871986343126692 (ac)SDQEAKPSTEDLGDKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDQEAKPSTEDLGDKK 16 2 B8ZZJ0;B9A032;B8ZZN6;P63165 B8ZZJ0 SUMO1 Small ubiquitin-related modifier 1 1 22465100.0 5833200.0 5718900.0 10913000.0 True False 5648028.258932242 8002486.593669518 8054557.917017594 1.0 1.416863766751476 1.4260831475620672 22.429315876226365 -11.618375184922472 0.5997966923051408 0.0017687809794279044 1.4249539795012658 0.9999565433560675 0.0013099832966804276 5.2014864176854445 0.29873021821357243 6.7508769719436375 0.0016049706498503975 2.4078244219464622e-12 11.618375184922472 1.4231851985218378 (ac)SDSEK(ub)LNLDSIIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDSEKLNLDSIIGR 14 1 P62136;P62136-2;P62136-3;E9PMD7 P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase 1 10489900.0 2188000.0 4614600.0 3687300.0 True False 2868489.1886221385 3926119.6675699116 3305773.5670791566 1.0 1.3687064546531547 1.1524441438341502 21.451859649785515 -10.114847274038029 4.144446248288952 0.9999450510609528 1.2605752990054695 0.6593685802317734 0.08828871886819772 30773460.50987952 1.9135277720161838 16418.0971458884 0.030223576783805786 7.676313906287796e-11 10.114847274038029 0.2606302479445167 (ac)SDSEK(ub)LNLDSIIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDSEKLNLDSIIGR 14 1 P62136;P62136-2;P62136-3;E9PMD7 P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase 1 20887700.0 8078400.0 4947700.0 7861600.0 True False 7821955.613892589 6923342.411914654 5802411.117055403 1.0 0.8851165557137775 0.7418107955956348 22.899097918767733 -6.968140302745601 0.29929332669831954 1.025063666053166 0.5973778334224873 0.999964022098302 0.0006334870208138539 0.07691089029881579 0.011178635997801516 0.0023858593264673104 0.012862105786399246 1.0761175080107935e-07 6.968140302745601 -0.4276858326306787 (ac)SDSEK(ub)LNLDSIIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDSEKLNLDSIIGR 14 1 P62136;P62136-2;P62136-3;E9PMD7 P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase 1 60495300.0 9671300.0 14122000.0 36702000.0 True False 14672069.166737834 11601818.76431039 29447833.61294193 1.0 0.7907418260140278 2.007067529350348 23.806569009393623 -6.8625707981943735 1.1727644955982504 0.8856060405839836 2.06890199418679 0.9566844504541985 0.11050884183344258 0.14417196876947516 0.3753537591523105 0.07341726292645713 0.17189445935894784 1.3722372422124182e-07 6.8625707981943735 1.1832959536028065 up (ac)SDSEK(ub)LNLDSIIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDSEKLNLDSIIGR 14 1 P62136;P62136-2;P62136-3;E9PMD7 P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase 1 11857200.0 2188000.0 3908200.0 5761000.0 True False 2996962.72847672 3735522.801310869 4400370.451519355 1.0 1.2464361888175834 1.4682766688112774 21.515069711308406 -6.972373307195712 0.19326573999022356 0.8559165408562859 1.8648774217509492 0.9999954600529548 0.0004074818733176568 0.07553987275114156 0.006189506324633057 0.0076180001349812855 0.023968436173335134 1.0656796994343869e-07 6.972373307195712 1.0089608808946633 (ac)SDSEK(ub)LNLDSIIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDSEKLNLDSIIGR 14 1 P62136;P62136-2;P62136-3;E9PMD7 P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase 1 21888000.0 8078400.0 7443800.0 6365800.0 True False 6717547.533800154 7403698.771921381 7696859.347866356 1.0 1.1021431161698185 1.145784128677717 22.67950319420201 -13.999999999999984 0.11613137789053227 0.5114316401594374 1.2192122080279597 0.9997121079050757 0.0010365657064784672 11.979915850993514 0.10435617427189157 1.3582636572638345 0.06515647171472663 1.0000000000000368e-14 13.999999999999984 0.7077805678685223 (ac)SDSEK(ub)LNLDSIIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDSEKLNLDSIIGR 14 1 P62136;P62136-2;P62136-3;E9PMD7 P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase 1 62291300.0 9671300.0 11376000.0 41244000.0 True False 12519688.499823976 10742915.599692302 33738015.19917712 1.0 0.8580817006623882 2.6947966955928235 23.577695331486073 -6.88824390548148 1.0327373572001068 0.8971161027302154 2.8474283426513147 0.9797494558117744 0.11873868673889389 0.12057862512196309 0.23027432333577982 0.08780165759790486 0.2175473745382881 1.2934692081406304e-07 6.88824390548148 1.9503122399210993 up (ac)SEEKPK(ub)EGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEEKPKEGVK 10 2 A8MUA9;A8MU27;P55854;P55854-2 A8MUA9 SUMO3 Small ubiquitin-related modifier 3 1 73526500.0 2741200.0 1448300.0 69337000.0 True False 3548537.437130211 1367700.8318419799 56718377.45769917 1.0 0.3854266316964865 15.983592807624065 21.758793096202268 -6.897725873495174 0.9755167889315298 0.31040324800046487 17.54741337765915 0.9854010244429663 0.8714657562602709 0.11309920255588386 0.18700363744903056 0.6727600386641355 1.7312943720728717 1.2655349005490217e-07 6.897725873495174 17.237010129658685 up (ac)SEGDSVGESVHGK(ub)PSVVYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEGDSVGESVHGKPSVVYR 19 1 O15258;Q5T092;A0A0A0MR06;Q5T091;Q5T093 O15258 RER1 Protein RER1 1 25564500.0 9610200.0 6532300.0 9422000.0 True False 12599065.26530919 5557706.302705969 8447101.822205909 1.0 0.4411205264575299 0.6704546443984637 23.58681336721242 -10.27238858847893 5.63837608476419 1.0000350787339085 0.5557875854279923 0.833401368560489 0.09362526159445207 4.128832828361272e-05 5.328070085808794e-06 0.09065941033148127 0.030217423244964736 5.3408626755924827e-11 10.27238858847893 -0.4442474933059162 (ac)SEGDSVGESVHGK(ub)PSVVYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEGDSVGESVHGKPSVVYR 19 1 O15258;Q5T092;A0A0A0MR06;Q5T091;Q5T093 O15258 RER1 Protein RER1 1 27162700.0 8941600.0 4914100.0 13307000.0 True False 8657753.802384378 6876325.756692959 9821497.498557074 1.0 0.7942390039780518 1.1344163535641538 23.045561345026986 -6.742918933688847 1.675757456410786 0.8779925922149834 1.1347563298297585 0.6181127043691852 0.08644861752159476 0.3125441103467612 1.7243487237862039 0.040791006999848584 0.09978830338853593 1.8075114883768987e-07 6.742918933688847 0.2567637376147751 (ac)SEGDSVGESVHGK(ub)PSVVYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEGDSVGESVHGKPSVVYR 19 1 O15258;Q5T092;A0A0A0MR06;Q5T091;Q5T093 O15258 RER1 Protein RER1 1 77899400.0 9051400.0 34272000.0 34576000.0 True False 13731635.545977358 28155893.83164179 27742038.444800857 1.0 2.0504399302885647 2.0203011033836975 23.711000136276446 -9.987437456357519 5.78326322814148 0.9999985572881824 2.035370516836514 0.9993648935125342 0.012304124561853902 2.2888551443680347e-07 4.008924757258963e-08 0.011913434061562296 0.003971139126279074 1.0293487551543581e-10 9.987437456357519 1.0353719595483315 (ac)SEGDSVGESVHGK(ub)PSVVYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEGDSVGESVHGKPSVVYR 19 1 O15258;Q5T092;A0A0A0MR06;Q5T091;Q5T093 O15258 RER1 Protein RER1 1 25924000.0 9610200.0 5135800.0 11178000.0 True False 13163350.645889856 4908883.3741805395 8537986.618136315 1.0 0.3729205052904442 0.6486180341022997 23.650023428735313 -10.418382555755834 6.048386634507591 1.0001484795192201 0.5107692696964187 0.8076390679804706 0.11255304482255209 0.00022542125975797713 2.1676746798640896e-05 0.10901162165544928 0.03632633901355669 3.816079768039718e-11 10.418382555755834 -0.4893792098228015 (ac)SEGDSVGESVHGK(ub)PSVVYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEGDSVGESVHGKPSVVYR 19 1 O15258;Q5T092;A0A0A0MR06;Q5T091;Q5T093 O15258 RER1 Protein RER1 1 28974800.0 8941600.0 10044000.0 9989200.0 True False 7435336.580044 9989890.97842209 12077895.535157654 1.0 1.3435694364172244 1.624391230327623 22.825966620461262 -6.973427281401471 0.15589882453981377 0.6992728379568286 2.2761117183924027 0.9999982739735742 0.00033540561199161634 0.07520534213988636 0.0047926679104673174 0.01352238538704211 0.0342231787155704 1.0630965740731485e-07 6.973427281401471 1.5768388804355742 (ac)SEGDSVGESVHGK(ub)PSVVYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEGDSVGESVHGKPSVVYR 19 1 O15258;Q5T092;A0A0A0MR06;Q5T091;Q5T093 O15258 RER1 Protein RER1 1 52070400.0 9051400.0 19378000.0 23641000.0 True False 11717215.729768151 18299597.265368994 19338580.577144478 1.0 1.561770107114951 1.65044162565121 23.482126458368896 -11.55051708542175 0.31479276227107844 1.8245579856972274e-13 1.6715695864674396 0.999424750798546 0.006907614394360231 4.025758638814904 0.1664910644414788 2.7521178078617603 0.03008558527595995 2.8150292679090955e-12 11.55051708542175 1.671569586467257 (ac)SEK(ub)ENNFPPLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEKENNFPPLPK 12 1 Q969E2-2;Q969E2;K7EJJ4;C9JWM2;Q969E2-3 Q969E2-2 SCAMP4 Secretory carrier-associated membrane protein 4 1 12225700.0 3426400.0 4006000.0 4793300.0 True False 4492043.581304802 3408320.4152657 4297335.2965803 1.0 0.7587460703744301 0.9566548540323945 22.09894049399664 -10.007880730364603 5.950436407336624 1.000000177689166 0.8577004623514756 0.40804289022924056 0.08079592259621202 1.9044602850505761e-07 3.17367520247806e-08 0.07823041358444849 0.0260767718880398 9.820175959952486e-11 10.007880730364603 -0.14229971533769048 (ac)SESSSK(ub)SSQPLASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SESSSKSSQPLASK 14 1 P17096;P17096-3;A0A669KAX1;A0A1W2PRV2;P17096-2 P17096;P17096-2 HMGA1 High mobility group protein HMG-I/HMG-Y 1 11529100.0 4812300.0 4867500.0 1849300.0 True False 6308971.902379499 4141287.9733663937 1657952.175738204 1.0 0.6564124927873686 0.26279276582494987 22.58897349494653 -7.351559152719184 0.3411922091363221 1.0560268735558072 3.549195736051825e-11 0.9996887812638497 0.005313488061647018 0.10963755700094537 0.028296789513189577 0.014194728998445177 0.05436325744012429 4.450828366533495e-08 7.351559152719184 -1.056026873520315 down (ac)SESSSK(ub)SSQPLASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SESSSKSSQPLASK 14 1 P17096;P17096-3;A0A669KAX1;A0A1W2PRV2;P17096-2 P17096;P17096-2 HMGA1 High mobility group protein HMG-I/HMG-Y 1 19653800.0 8870500.0 6983900.0 3799400.0 True False 8588910.832966208 9772607.690557366 2804223.160443207 1.0 1.1378168758077984 0.32649345359133963 23.034043762910805 -6.863168334546205 1.1695439538398267 1.075507204738919 0.2847449837090879 0.9573810691534791 0.07317834266573735 0.1435780497429787 0.3713851752893612 0.04873284321802386 0.11420030340534287 1.3703505090288114e-07 6.863168334546205 -0.7907622210298311 down (ac)SESSSK(ub)SSQPLASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SESSSKSSQPLASK 14 1 P17096;P17096-3;A0A669KAX1;A0A1W2PRV2;P17096-2 P17096;P17096-2 HMGA1 High mobility group protein HMG-I/HMG-Y 1 22091100.0 8659100.0 6663500.0 6768500.0 True False 13136487.765005678 5474346.3628368685 5430703.0082610585 1.0 0.4167283113085975 0.4134060112116057 23.647076265493663 (ac)SESSSK(ub)SSQPLASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SESSSKSSQPLASK 14 1 P17096;P17096-3;A0A669KAX1;A0A1W2PRV2;P17096-2 P17096;P17096-2 HMGA1 High mobility group protein HMG-I/HMG-Y 1 10235800.0 4812300.0 3932300.0 1491200.0 True False 6591537.357517617 3758557.983622826 1139009.2722280256 1.0 0.5702096157182829 0.1727987281948711 22.65218355646942 -7.778511518683846 0.3697655385346196 1.0626910157268519 5.781041224041227e-20 0.998599307046972 0.012642060708353333 0.11611333226200272 0.06223265254458924 0.034225744026009225 0.07908823377042778 1.665284659271069e-08 7.778511518683846 -1.0626910157268519 down (ac)SESSSK(ub)SSQPLASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SESSSKSSQPLASK 14 1 P17096;P17096-3;A0A669KAX1;A0A1W2PRV2;P17096-2 P17096;P17096-2 HMGA1 High mobility group protein HMG-I/HMG-Y 1 23702400.0 8659100.0 11295000.0 3748300.0 True False 11209375.646379042 10666423.320897024 3066147.860805828 1.0 0.9515626612390845 0.27353422327284427 23.418202587586112 -6.921293704898016 0.8150898635915426 1.014274595376896 0.1608807913568771 0.9945323970509831 0.024521984149132068 0.09741681565366622 0.10171896968181783 0.02127411535589582 0.06453443647710977 1.1986883793738954e-07 6.921293704898016 -0.8533938040200189 down (ac)SETAPAAPAAAPPAEK(ub)APVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SETAPAAPAAAPPAEKAPVK 20 1 P16403 P16403 HIST1H1C Histone H1.2 1 65974000.0 27384000.0 22771000.0 15819000.0 True False 35900689.187033206 19373655.56066279 14182201.626562865 1.0 0.5396457839494699 0.395039815327146 25.097508204002796 -13.999999999999998 0.16209803500327905 3.277522625627952 0.25612516002108826 0.9995310072586346 0.005586083761458463 12.024337956141562 0.12729986905999602 8.609139490110145 0.12695012498585426 1.0000000000000041e-14 13.999999999999998 -3.0213974656068636 (ac)SETAPAAPAAAPPAEK(ub)APVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SETAPAAPAAAPPAEKAPVK 20 1 P16403 P16403 HIST1H1C Histone H1.2 1 117864000.0 31371000.0 14373000.0 72120000.0 True False 47592100.52730576 11808025.853238435 57865450.38868114 1.0 0.24810894502258063 1.2158625012880255 25.504218794974932 -6.699270318655906 1.8330413379508976 0.5327983791319908 1.212993441254288 0.4143908191935872 0.3174212561658302 0.39699777284524035 2.5927374200479876 0.13816274888591407 0.355695344034541 1.998617479508678e-07 6.699270318655906 0.6801950621222972 (ac)SETAPAAPAAAPPAEK(ub)APVK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SETAPAAPAAAPPAEKAPVKK 21 2 P16403 P16403 HIST1H1C Histone H1.2 2 13050700.0 7438500.0 3662900.0 1949300.0 True False 10188714.467904067 3501060.966409492 1488915.4870936768 1.0 0.343621462495425 0.1461337926177024 23.280468699250477 -12.613443666664374 0.19061858059206793 3.0295330698709746 2.5399745951582424e-17 0.999437980022001 0.008652665790858313 7.039160701230118 0.12888495508781692 5.569240757912539 0.13345229778244017 2.4353216706377673e-13 12.613443666664374 -3.0295330698709746 (ac)SETAPAAPAAPAPAEKTPVK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SETAPAAPAAPAPAEKTPVK 20 1 P10412 P10412 HIST1H1E Histone H1.4 1 30819700.0 13436000.0 10516000.0 6867700.0 True False 18403652.294247378 10051368.34823835 5245690.7047213055 1.0 0.5461616089856366 0.28503530825568824 24.13348876875035 -8.903047439799831 0.1971731501748982 1.3853078715350517 9.653059499594674e-20 0.9996265565173803 0.005708437681428178 0.39461107589749234 0.0618400284201065 0.23510227897226801 0.13815768983760157 1.250122466661725e-09 8.903047439799831 -1.3853078715350517 down (ac)SETAPAAPAAPAPAEKTPVK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SETAPAAPAAPAPAEKTPVK 20 1 P10412 P10412 HIST1H1E Histone H1.4 1 52126000.0 24532000.0 17576000.0 10018000.0 True False 31757157.598014873 16597880.149454307 8194826.793360404 1.0 0.5226500545027315 0.258046607857394 24.920578455069023 -8.99592939615687 0.20749782237020845 1.3831530467375888 3.8638971060575356e-11 0.9995342923639002 0.006625652059821246 0.46351274286130395 0.06815298319437128 0.2549108331021043 0.13418146815946744 1.009416975025348e-09 8.99592939615687 -1.38315304669895 down (ac)SETAPAAPAAPAPAEKTPVKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SETAPAAPAAPAPAEKTPVKK 21 2 P10412 P10412 HIST1H1E Histone H1.4 1 15073500.0 4553500.0 9345900.0 1174100.0 True False 3786437.0042531965 9295551.781684106 1419598.8815749611 1.0 2.454960103982366 0.37491680964990737 21.852409495813667 -6.718635148926413 1.7639570058168577 1.8864512436871494 0.37834575622793476 0.5061867869336932 0.6123567543931985 0.35797825250663784 2.1760573234298386 0.27570506692820124 0.693306832781508 1.9114584016636533e-07 6.718635148926413 -1.5081054874592148 (ac)SGALDVLQMK(ub)EEDVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGALDVLQMKEEDVLK 16 1 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 1 19503900.0 6440100.0 3983800.0 9080000.0 True False 6235662.550632517 5574552.115242556 6701675.605838894 1.0 0.8939791192961682 1.0747335269383855 22.572111426528952 -6.747711074898867 1.6580981495761358 0.9374893199785407 1.0750360630411142 0.6391827340329306 0.044546627865163044 0.304039467170049 1.6438548775717323 0.021228732111132693 0.05166647949466299 1.7876764751426975e-07 6.747711074898867 0.13754674306257353 (ac)SGALDVLQMK(ub)EEDVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGALDVLQMKEEDVLK 16 1 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 1 15462400.0 6440100.0 5702700.0 3319600.0 True False 5355228.494804222 5671978.423202679 4013713.0119037884 1.0 1.0591477896238741 0.749494258890726 22.35251670196323 -6.8572323627851155 1.199571895989045 1.0318860738803968 0.7352681888828574 0.9501909196148008 0.029955317508302944 0.1496845432406052 0.41086039625281146 0.019496721688277516 0.045380663384803635 1.3892091566991355e-07 6.8572323627851155 -0.2966178849975394 (ac)SGEDEQQEQTIAEDLVVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGEDEQQEQTIAEDLVVTK 19 0 Q9UQ80;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 11926880.0 4409500.0 661480.0 6855900.0 False True 4269522.836138265 925612.4135726296 5060134.117408684 1.0 0.2167952834771193 1.185175559802256 22.025643411909133 -6.691547055466345 1.861124524665272 0.5096803596782806 1.1818707722352462 0.37754407334055806 0.33113927216380945 0.41337371270516277 2.777323422111141 0.1422800885036564 0.36975825585186 2.0344777498403027e-07 6.691547055466345 0.6721904125569655 (ac)SGLRPGTQVDPEIELFVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGLRPGTQVDPEIELFVK 18 1 O15247;A6PVS0 O15247 CLIC2 Chloride intracellular channel protein 2 0 11826000.0 3972100.0 2634600.0 5219300.0 False True 3846007.859717618 3686609.519257496 3852208.754356275 1.0 0.9585548583689516 1.0016122938030376 21.874930280302568 -9.90960658777343 4.518554190580516 1.0000002281767548 0.9800835761282763 0.22195693797471683 0.01757812442684397 4132858.589370726 9063739.43133713 4.764628494121421 0.0060174601659739105 1.231383733316881e-10 9.90960658777343 -0.019916652048478478 (ac)SGLRPGTQVDPEIELFVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGLRPGTQVDPEIELFVK 18 1 O15247;A6PVS0 O15247 CLIC2 Chloride intracellular channel protein 2 0 41308700.0 3703600.0 31435000.0 6170100.0 False True 5618631.969428115 25825178.647223953 4950577.030549104 1.0 4.596346368251726 0.8811000715985661 22.421787473582533 -6.653583438971736 1.9956228499213453 3.3270478020315033 0.8966839053754142 0.20870152511034934 1.5336212022282576 0.49984990531271345 3.8195917380715265 0.6223626724171087 1.6991855900189907 2.220325061778914e-07 6.653583438971736 -2.430363896656089 (ac)SGLRPGTQVDPEIELFVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGLRPGTQVDPEIELFVK 18 1 O15247;A6PVS0 O15247 CLIC2 Chloride intracellular channel protein 2 0 4222200.0 1041700.0 1148100.0 2032400.0 False True 1426844.6408840038 1097373.1457410099 1552388.9785918994 1.0 0.7690908416358003 1.08798739127626 20.44439682773417 -6.712471889600614 1.7864486313274646 0.8584029897855835 1.0872928237255537 0.47683828671878714 0.09726688292656024 0.3701137529878311 2.3040141898614834 0.04330449572248641 0.10968299733403132 1.9387781223810138e-07 6.712471889600614 0.2288898339399702 (ac)SGLRPGTQVDPEIELFVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGLRPGTQVDPEIELFVK 18 1 O15247;A6PVS0 O15247 CLIC2 Chloride intracellular channel protein 2 0 8955200.0 3972100.0 2781300.0 2201800.0 False True 3302977.1438660678 2766316.5848551756 2662186.200027037 1.0 0.8375221699588445 0.8059959497361227 21.655335555736844 -13.999999999999982 0.23054626052311666 2.028274225364239 0.790747083456873 0.9995105404620263 0.0018805882086565546 13.308341847642662 0.1520268076891042 6.2661571795001105 0.01630948075792154 1.0000000000000409e-14 13.999999999999982 -1.237527141907366 (ac)SHTILLVQPTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHTILLVQPTK 11 0 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 0 66942000.0 19061000.0 23776000.0 24105000.0 False True 24989155.586986605 20228713.47812213 21610845.831487287 1.0 0.8094996810799189 0.8648089670841614 24.57479881609436 -10.0791337763972 5.597060607472589 1.0000011419106476 0.8371543240819967 0.9203715740873077 0.022579921458162226 3.217427000470378e-07 5.296825376852806e-08 0.021863068381272083 0.0072876383138221965 8.334244240693496e-11 10.0791337763972 -0.16284681782865085 (ac)SHTILLVQPTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHTILLVQPTK 11 0 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 0 45479100.0 18940000.0 7414100.0 19125000.0 False True 18338760.067231834 10374588.794020742 14115588.762298321 1.0 0.5657192065323066 0.7697133672368841 24.128392761959738 -10.062336695688625 4.856323479064518 1.0000092877952764 0.6677162868807999 0.7796241851687482 0.0832802673853483 115508179.16338669 4.046180548511654 11996.37376380242 0.028509050649282882 8.662900062882211e-11 10.062336695688625 -0.33229300091447656 (ac)SHTILLVQPTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SHTILLVQPTK 11 0 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 0 130691000.0 14492000.0 100880000.0 15319000.0 False True 21985423.50711531 82877175.82096241 12291192.935443787 1.0 3.7696419991245675 0.5590610038267353 24.39004398778917 -6.678449026474476 1.9074047804150855 2.754753783774406 0.5714028464085232 0.31716524081755093 1.1742267013962746 0.4419011446759574 3.107015346079226 0.49422433919767933 1.3060760163921559 2.0967708656917313e-07 6.678449026474476 -2.1833509373658826 (ac)SHTILLVQPTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHTILLVQPTK 11 0 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 0 74911000.0 19061000.0 30601000.0 25249000.0 False True 26108366.804156702 29248946.636025235 19285706.21947792 1.0 1.1202901681068969 0.7386791507926667 24.638008877617253 -6.821957742674809 1.3633302767696842 1.064711091018996 0.7299896413709955 0.8888358727986588 0.053112302376290076 0.1909509342850919 0.6968397484394516 0.030609347488343958 0.07051729011875624 1.5067536678241796e-07 6.821957742674809 -0.33472144964800055 (ac)SHTILLVQPTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SHTILLVQPTK 11 0 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 0 31164200.0 18940000.0 7331000.0 4893200.0 False True 15749449.184266059 7291506.44791043 5916345.496399454 1.0 0.46296898149268334 0.37565412143492444 23.908798037394014 -13.999999999999979 0.25564017323075133 4.843582320954304 0.34238284654514267 0.99955357131902 0.0058326252644561385 14.228752949121985 0.1599903586842198 28.17861227665374 0.0390700856541414 1.000000000000049e-14 13.999999999999979 -4.501199474409161 (ac)SHTILLVQPTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SHTILLVQPTK 11 0 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 0 45431000.0 14492000.0 18223000.0 12716000.0 False True 18760179.68002737 17208874.0306956 10401818.477178177 1.0 0.9173085932122849 0.554462625336806 24.16117030988162 -6.942754090377051 0.6334225804923337 1.0039598960076346 0.44814081265806743 0.9985028520093279 0.007487296673711742 0.08653234184295706 0.04905434149193744 0.007450519911502163 0.03087050818035569 1.1408956115508525e-07 6.942754090377051 -0.5558190833495671 (ac)SHTILLVQPTK(ub)RPEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHTILLVQPTKRPEGR 16 2 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 1 487994000.0 222340000.0 203304000.0 62350000.0 True False 291489893.1436225 172971835.672785 55898620.103432156 1.0 0.5934059455967434 0.1917686390446816 28.11887062069154 -7.669266525644922 0.3661189145483879 1.058737757305326 1.1809037219960161e-21 0.9988999903675391 0.010943619354552415 0.1216480152909792 0.05369846189642026 0.028151563654973445 0.07492556022724892 2.1415759169442103e-08 7.669266525644922 -1.058737757305326 down (ac)SHTILLVQPTK(ub)RPEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHTILLVQPTKRPEGR 16 2 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 1 647716400.0 264944000.0 322207000.0 60565400.0 True False 256533497.74301362 450865935.38730806 44701504.816946566 1.0 1.7575324055300177 0.17425211604032698 27.934571982094408 -6.776592989980891 1.5490742710467271 1.4308308435084016 0.16300873147064865 0.7551750792101346 0.3199221530146517 0.2559035105226274 1.2126424552415245 0.16270193209835787 0.38502729475252695 1.6726574530824462e-07 6.776592989980891 -1.267822112037753 (ac)SHTILLVQPTK(ub)RPEGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SHTILLVQPTKRPEGR 16 2 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 1 616231000.0 386082000.0 142410000.0 87739000.0 True False 585714620.374973 116995822.84559132 70397348.19263011 1.0 0.19974885170305445 0.12019052580173242 29.125622665974557 -13.999999999999998 0.32632858334699133 9.52116167429795 0.1054878711020522 0.9997071710621325 0.006799100628753523 18.517923417450323 0.1824811589268143 108.09256476153556 0.02584962722808226 1.0000000000000041e-14 13.999999999999998 -9.415673803195897 (ac)SHTILLVQPTK(ub)RPEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHTILLVQPTKRPEGR 16 2 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 1 457011300.0 222340000.0 190795000.0 43876300.0 True False 304545106.5125748 182365046.0253077 33513621.600763526 1.0 0.5988112832073292 0.11004485340295472 28.18208068221443 -7.627048724345635 0.48410742406328783 1.0198859794292505 1.3894299979735277e-21 0.9966264307697889 0.02113669629651148 0.1179584643185586 0.07983807917428544 0.02611701538526485 0.07349384907361106 2.3602134213752726e-08 7.627048724345635 -1.0198859794292505 down (ac)SHTILLVQPTK(ub)RPEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SHTILLVQPTKRPEGR 16 2 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 1 544780000.0 264944000.0 253679000.0 26157000.0 True False 220312675.0093027 252312380.87566078 31626307.763696637 1.0 1.1452467764962089 0.14355192120635463 27.714977257528684 -6.870082982141654 1.1335824152082952 1.0821972115402534 0.08477639808806377 0.9647697392855954 0.0829554998207892 0.1367792131901353 0.32844044646789516 0.05678799828687165 0.13447481564298716 1.3487051562331792e-07 6.870082982141654 -0.9974208134521896 down (ac)SHTILLVQPTK(ub)RPEGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SHTILLVQPTKRPEGR 16 2 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 1 675909000.0 386082000.0 234890000.0 54937000.0 True False 499790759.81398994 221818165.01509523 44939029.70122193 1.0 0.44382206085132625 0.08991568735273768 28.896748988067007 -8.3477440197407 0.38851872866513454 1.0917033773417428 1.6032035308799616e-18 0.9972230852283467 0.01973938712053481 0.1322557150041999 0.10781652504587518 0.08024986159390907 0.08272666413074853 4.4900996575859215e-09 8.3477440197407 -1.0917033773417428 (ac)SILK(ub)IHAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SILKIHAR 8 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5 P06733 ENO1 Alpha-enolase;Enolase 1 66671000.0 23894000.0 30664000.0 12113000.0 True False 31325265.389825135 26089050.72733582 10859662.956100622 1.0 0.832843725429694 0.3466742522675637 24.900823396423085 -6.9521457870121255 0.5347759063267535 1.0074141466422812 0.14985281806852113 0.9993590488899101 0.007015731633061647 0.08263552924099572 0.03248475508067824 0.007773095163067965 0.040229783256579076 1.1164883942267818e-07 6.9521457870121255 -0.8575613285737601 down (ac)SILK(ub)IHAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SILKIHAR 8 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5 P06733 ENO1 Alpha-enolase;Enolase 1 110114000.0 38169000.0 44301000.0 27644000.0 True False 36957345.98765433 61990620.32666302 20403207.097776446 1.0 1.6773558455028428 0.5520744672680818 25.13935782064274 -6.743705670216676 1.6730214528671725 1.4012855317490773 0.5508542416937623 0.6214900380347244 0.2845852845695265 0.31116021035399316 1.7114200429891508 0.13448996392040377 0.32870719366165135 1.8042400950694952e-07 6.743705670216676 -0.850431290055315 (ac)SILK(ub)IHAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SILKIHAR 8 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5 P06733 ENO1 Alpha-enolase;Enolase 1 139493000.0 40530000.0 58870000.0 40093000.0 True False 61486973.13989679 48364188.54659062 32168600.976613805 1.0 0.7865761815360651 0.5231775014103061 25.873777452270087 -6.9682959460536535 0.296071433360896 1.0478682612231274 0.25367783428605617 0.999965872345535 0.0011392588412885035 0.07685960794838417 0.01099872808926942 0.004457312282417503 0.02372332624216268 1.0757319160068006e-07 6.9682959460536535 -0.7941904269370712 (ac)SILK(ub)IHAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SILKIHAR 8 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5 P06733 ENO1 Alpha-enolase;Enolase 1 68134000.0 23894000.0 28037000.0 16203000.0 True False 32728257.511070732 26798232.634039458 12376185.11125987 1.0 0.8188102475353181 0.3781498329715071 24.964033457945977 -6.95604948591115 0.4879332592789455 1.0098266102421452 0.16851279554246215 0.9995944711829985 0.005258605303884938 0.0811436854424817 0.026584133158731 0.006316569038768412 0.03634464722576621 1.106497696337386e-07 6.95604948591115 -0.841313814699683 down (ac)SILK(ub)IHAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SILKIHAR 8 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5 P06733 ENO1 Alpha-enolase;Enolase 1 105810000.0 38169000.0 55337000.0 12304000.0 True False 31739214.67340297 55038888.59746553 14876709.512731722 1.0 1.734097367052606 0.4687170009029304 24.919763096077016 -6.7494219709940655 1.651978925353523 1.4319569522825604 0.46631212235629194 0.6464788170413667 0.30846417847389157 0.30105622147240246 1.6163052782425074 0.14751520207864674 0.35834536286395874 1.7806478063035485e-07 6.7494219709940655 -0.9656448299262684 (ac)SIMSYNGGAVMAMK(ub)GK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIMSYNGGAVMAMKGK 16 1 P49720;A0A087WXQ8;A0A087WY10 P49720 PSMB3 Proteasome subunit beta type-3 1 23296000.0 3633200.0 3877800.0 15785000.0 True False 3517866.0547131347 5426225.762459847 11650434.960150542 1.0 1.5424765121997603 3.3117903805750726 21.746269121525753 -6.949557741390507 0.5636768458606972 0.9772897615787649 3.9620710790722176 0.9991661270485233 0.028504069090985674 0.08366379731360993 0.036700906079212434 0.030420805372716186 0.14719833759624135 1.1231616303931715e-07 6.949557741390507 2.9847813174934528 (ac)SIMSYNGGAVMAMK(ub)GK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIMSYNGGAVMAMKGK 16 1 P49720;A0A087WXQ8;A0A087WY10 P49720 PSMB3 Proteasome subunit beta type-3 1 51959700.0 4294200.0 9810500.0 37855000.0 True False 6514615.348071675 8059739.625213634 30372942.65756407 1.0 1.2371781286518038 4.662277208209147 22.635248567486414 -6.920896070669787 0.818058794173397 0.9268407268411171 5.226142084282168 0.9944261220183542 0.12492699456886286 0.09764738128174315 0.10290495453158803 0.10815118657056426 0.3267893761815536 1.1997863850301785e-07 6.920896070669787 4.299301357441051 up (ac)SIMSYNGGAVMAMK(ub)GK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIMSYNGGAVMAMKGK 16 1 P49720;A0A087WXQ8;A0A087WY10 P49720 PSMB3 Proteasome subunit beta type-3 1 18647300.0 3633200.0 6010300.0 9003800.0 True False 3021166.778050449 5977921.320948858 10886452.951132458 1.0 1.9786796824260044 3.60339357304778 21.52667439696003 -6.963517092801937 0.3826496148750363 0.8916697707816906 4.7481000230687656 0.9998792391933838 0.011798838290847952 0.07846783455087437 0.016656891572114457 0.02109000807588996 0.13711526294537874 1.0876343300780446e-07 6.963517092801937 3.856430252287075 (ac)SIMSYNGGAVMAMK(ub)GK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIMSYNGGAVMAMKGK 16 1 P49720;A0A087WXQ8;A0A087WY10 P49720 PSMB3 Proteasome subunit beta type-3 1 26234400.0 4294200.0 8031200.0 13909000.0 True False 5558926.551336853 7584256.660007811 11377704.718391895 1.0 1.3643383466154795 2.046744926977979 22.406374889578863 -6.961307326515262 0.4165995616290284 0.9687091633256675 2.46797322289768 0.9998156546248613 0.005890656289520983 0.07923737507967993 0.019429881081058198 0.008810227184410947 0.056860140651033925 1.0931825068653621e-07 6.961307326515262 1.4992640595720126 up (ac)SK(ub)AHPPELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKAHPPELK 9 1 P62308;A8MWD9;C9JVQ0 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 1 28324700.0 13592700.0 11294600.0 3437400.0 True False 13161207.178767813 15804592.68056089 2537041.8202104173 1.0 1.2008467358569883 0.19276665018261202 23.64978848694334 -6.8549101401966634 1.2110637662117174 1.1078226278099064 0.1484623941850157 0.94715670058238 0.10014790422772828 0.15214386377404002 0.4269329577889675 0.06461397844635275 0.15007744923392005 1.3966573133076642e-07 6.8549101401966634 -0.9593602336248906 down (ac)SK(ub)AHPPELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKAHPPELK 9 1 P62308;A8MWD9;C9JVQ0 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 1 17221500.0 11898000.0 3826100.0 1497400.0 True False 18050135.860313136 3143302.561544254 1201438.2336662647 1.0 0.17414287548136623 0.06656117399691538 24.105506360285887 -13.999999999999998 0.2873122984657763 8.009734931815268 0.03644274421516539 0.9996214513395384 0.008113081150988015 15.807899443715563 0.16992517679417446 65.39201072152089 0.04113034845044417 1.0000000000000041e-14 13.999999999999998 -7.973292187600103 (ac)SK(ub)AHPPELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKAHPPELK 9 1 P62308;A8MWD9;C9JVQ0 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 1 18987900.0 9202000.0 7705700.0 2080200.0 True False 12604228.074699627 7365236.694657687 1588899.6030638022 1.0 0.5843465106317675 0.1260608419370948 23.587404429619095 -7.681017179701211 0.44812054165394716 1.0297975669423938 8.2217853335324e-21 0.9973157177402971 0.018492337863674792 0.11773743124005624 0.07507625873949217 0.027355080561636484 0.07499697628038929 2.0844084270133397e-08 7.681017179701211 -1.0297975669423938 down (ac)SK(ub)AHPPELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKAHPPELK 9 1 P62308;A8MWD9;C9JVQ0 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 1 39088400.0 13592700.0 23239200.0 2256500.0 True False 11302932.308710322 23114005.816979975 2728323.717122815 1.0 2.0449565816799367 0.24138193900535887 23.430193762377616 -6.749629029636998 1.6513307275407922 1.614717116740914 0.23792188425474034 0.6473428876439569 0.43908804790483236 0.3006850120794323 1.6131302800850766 0.21006509067361503 0.510157430097145 1.7797990489386318e-07 6.749629029636998 -1.3767952324861736 (ac)SK(ub)AHPPELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKAHPPELK 9 1 P62308;A8MWD9;C9JVQ0 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 1 24623500.0 11898000.0 6239400.0 6486100.0 True False 15402195.544642953 5892171.905126596 5305696.353006085 1.0 0.382554025369192 0.3444766259217805 23.876632682378336 -13.859524648049314 0.3973030404975444 9.999991249179185 0.3420685003221798 0.9998314531024531 0.0039005306266431867 23.46071049844626 0.2071632201235686 181.04845888167887 0.009820144742881154 1.3818959752323914e-14 13.859524648049314 -9.657922748857006 (ac)SK(ub)GPAVGIDLGTTYSCVGVFQHGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKGPAVGIDLGTTYSCVGVFQHGK 24 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 139197000.0 67960000.0 53478000.0 17759000.0 True False 89096218.12557621 45499290.85561132 15921469.03635688 1.0 0.5106758941382066 0.17869971780302107 26.408860859064543 -8.245797554761594 0.30604786120221544 1.1424338930912723 5.236978362052488e-25 0.9988802424171027 0.01128831001595837 0.0971084616138199 0.07214656174298352 0.083668908932411 0.09439390547613832 5.678092265154158e-09 8.245797554761594 -1.1424338930912723 down (ac)SK(ub)GPAVGIDLGTTYSCVGVFQHGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKGPAVGIDLGTTYSCVGVFQHGK 24 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 1273672900.0 387170000.0 507871800.0 378631100.0 True False 374879500.2761432 710667658.2564483 279456256.22047865 1.0 1.8957229129172368 0.7454562226385438 28.481851695264883 -6.698907746712213 1.8350405163123913 1.5568015445160324 0.7489746778221594 0.41233489291003433 0.3781709079479729 0.3977634309798721 2.6033206774991577 0.16446758710171164 0.4234951055700877 2.0002867275042016e-07 6.698907746712213 -0.8078268666938729 (ac)SK(ub)GPAVGIDLGTTYSCVGVFQHGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKGPAVGIDLGTTYSCVGVFQHGK 24 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 2518788300.0 800067300.0 844219000.0 874502000.0 True False 1213760586.8544233 693561523.5368462 701656296.3921574 1.0 0.5714154266075464 0.5780845942695889 30.17683673338831 -10.122755290362507 7.746455351587035 1.0000000680937646 0.5747500104388024 0.9998155673701905 0.002722676296845732 3.199586182633062e-09 3.651164195893129e-10 0.002636220381522778 0.0008787399962330961 7.537801726630458e-11 10.122755290362507 -0.42525005765496227 (ac)SK(ub)GPAVGIDLGTTYSCVGVFQHGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKGPAVGIDLGTTYSCVGVFQHGK 24 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 203299000.0 67960000.0 41406000.0 93933000.0 True False 93086648.54994428 39576546.00866841 71747960.01086062 1.0 0.42515813626520443 0.7707653152037728 26.472070920587434 -10.43126606336331 5.926237345006296 1.0001713227770481 0.5979617257345108 0.6434043892435501 0.14109353997370958 0.0003195108958667009 3.0663213584790277e-05 0.13667069555509406 0.045537744214635544 3.70453699889662e-11 10.43126606336331 -0.40220959704253734 (ac)SK(ub)GPAVGIDLGTTYSCVGVFQHGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKGPAVGIDLGTTYSCVGVFQHGK 24 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 1053650000.0 387170000.0 312160000.0 354320000.0 True False 321949009.5391918 310478332.12109166 428406673.8094203 1.0 0.964371136179241 1.3306662269984997 28.26225697069916 -6.883017802552372 1.062866175253055 0.9768998193074775 1.3581712973866171 0.9760375949042237 0.02552897499825748 0.1249886722779169 0.2564389970398158 0.01844979730525575 0.044977298302050925 1.3091282582557096e-07 6.883017802552372 0.38127147807913964 (ac)SK(ub)GPAVGIDLGTTYSCVGVFQHGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKGPAVGIDLGTTYSCVGVFQHGK 24 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 2585767200.0 800067300.0 1104041000.0 681658900.0 True False 1035702891.5342524 1042600147.8199636 557603974.6109588 1.0 1.0066594931249964 0.5383821742400899 29.94796305548076 -6.903674686868174 0.9377385681225254 1.017555335053277 0.4853883598340974 0.9883076461558541 0.023701841972094132 0.1087509199980261 0.16255522332347497 0.0188175354217248 0.049927703404872806 1.2483182308311813e-07 6.903674686868174 -0.5321669752191798 (ac)SK(ub)NTVSSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKNTVSSAR 9 1 O15511;B1ALC0;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 8939700.0 3145100.0 3815000.0 1979600.0 True False 4123256.5571917254 3245816.8707535304 1774769.9816640618 1.0 0.7871974071301052 0.4304291903855784 21.97535280068664 -6.963342536975475 0.3854413604414493 1.0230555585404653 0.18184507893751034 0.9998747965706996 0.002629390013937223 0.07852799917615776 0.01687161335268375 0.004620306287443894 0.03007053444206907 1.0880715704210763e-07 6.963342536975475 -0.8412104796029549 down (ac)SK(ub)NTVSSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKNTVSSAR 9 1 O15511;B1ALC0;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 22940800.0 9121300.0 9256900.0 4562600.0 True False 8831749.324247198 12953228.444095775 3367518.1849339763 1.0 1.4666662252893918 0.3812968485969814 23.074267793320033 -6.789870148872972 1.4968145164419675 1.260875840099163 0.36979141094637236 0.8008763756477049 0.1983713711284268 0.2355669363598794 1.0426389912894818 0.10431465591756274 0.24425318482276293 1.6222950801619734e-07 6.789870148872972 -0.8910844291527907 down (ac)SK(ub)NTVSSAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKNTVSSAR 9 1 O15511;B1ALC0;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 7659500.0 2706400.0 1915700.0 3037400.0 True False 4105806.664342872 1573828.367567582 2437056.558660288 1.0 0.38331770008451455 0.5935633988382975 21.96923426424251 -10.073494479309332 5.35119242307876 1.0000056362051175 0.48844054946094234 0.8875599621195396 0.08583244709528774 5.771700223485194e-06 9.993069129275563e-07 0.08310782554119268 0.027702303180114424 8.443169746800029e-11 10.073494479309332 -0.5115650867441752 (ac)SK(ub)NTVSSAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKNTVSSAR 9 1 O15511;B1ALC0;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 10127100.0 3145100.0 4876900.0 2105100.0 True False 4307928.46313169 4661422.432248346 1607918.7358953983 1.0 1.082056601483043 0.3732463873660767 22.03856286220953 -6.878067701928797 1.0904724660718912 1.0496722228709772 0.3248291528146011 0.9720951777250845 0.052882659417368215 0.12935770357357293 0.2827201063259042 0.037418357750822744 0.09006276789181436 1.3241351004093846e-07 6.878067701928797 -0.724843070056376 down (ac)SK(ub)NTVSSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKNTVSSAR 9 1 O15511;B1ALC0;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 23409000.0 9121300.0 12385000.0 1902700.0 True False 7584765.092103811 12318279.546769992 2300545.7729091877 1.0 1.62408187955538 0.30331140713958193 22.85467306875431 -6.778193050298544 1.542698746142741 1.3541967988475037 0.2933963383977609 0.7610188690917387 0.26372552382032577 0.25339011461614525 1.1909760214768152 0.13465605092654934 0.31824311161487 1.6665062612845648e-07 6.778193050298544 -1.0608004604497427 (ac)SK(ub)PHSEAGTAFIQTQQLHAAMADTFLEHMCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKPHSEAGTAFIQTQQLHAAMADTFLEHMCR 31 1 P14618;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 150690000.0 39849000.0 58794000.0 52047000.0 True False 60453846.352127954 48301751.340381354 41759887.63698953 1.0 0.7989855775104233 0.6907730468256565 25.84933079750904 -13.99999999999886 0.07622634220237265 2.110506840332179 0.343792052959843 0.9999017802233976 0.001269754968606742 12.296406181071413 0.07656776287414697 2.3449656232396454 0.31667420456840306 1.000000000002626e-14 13.99999999999886 -1.766714787372336 (ac)SK(ub)PHSEAGTAFIQTQQLHAAMADTFLEHMCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKPHSEAGTAFIQTQQLHAAMADTFLEHMCR 31 1 P14618;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 23946100.0 7318600.0 9052300.0 7575200.0 True False 9474071.971173638 8548531.547388764 6196591.328115769 1.0 0.9023080649375498 0.6540578694113658 23.17555320092903 -6.955110808867681 0.4995970875481777 1.0049890885597685 0.5406769558173312 0.9995437124241348 0.003110576840359803 0.08149612054290649 0.027954240071408423 0.0036506738238363244 0.020478118436790534 1.1088918489061553e-07 6.955110808867681 -0.4643121327424373 (ac)SK(ub)QQPTQFINPETPGYVGFANLPNQVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKQQPTQFINPETPGYVGFANLPNQVHR 28 1 Q15019;Q15019-3;C9JB25;C9J938;C9IZU3;C9JZI2;F8WB65;C9JFT1;A0A1B0GXJ2;C9JSE7;C9JT15 Q15019 SEPT2 Septin-2 1 11392000.0 2883000.0 4425300.0 4083700.0 True False 3779640.9190117125 3765062.489684295 3661157.897616453 1.0 0.9961429062601985 0.9686523074720442 21.849817748487865 -6.932311361737232 0.7275794955783683 1.0003842539227374 0.9626615975918704 0.9969731462205546 0.0007678720509662561 0.09145467413359493 0.07193203695000029 0.0007094537452482629 0.002456559328052358 1.1686612342468032e-07 6.932311361737232 -0.03772265633086702 (ac)SK(ub)QQPTQFINPETPGYVGFANLPNQVHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKQQPTQFINPETPGYVGFANLPNQVHR 28 1 Q15019;Q15019-3;C9JB25;C9J938;C9IZU3;C9JZI2;F8WB65;C9JFT1;A0A1B0GXJ2;C9JSE7;C9JT15 Q15019 SEPT2 Septin-2 1 46670000.0 11682000.0 12853000.0 22135000.0 True False 11311161.304403493 17985269.927509528 16337179.464233913 1.0 1.5900462776096889 1.4443414804697166 23.43124372104544 -10.035391260044362 4.516541325401493 0.9999788219080616 1.5171938789144264 0.9438188206760829 0.059483734487104444 20570475.170790993 0.019674520509725187 4866.561960089017 0.020362864468232943 9.217406480341235e-11 10.035391260044362 0.5172150570063647 (ac)SK(ub)QQPTQFINPETPGYVGFANLPNQVHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKQQPTQFINPETPGYVGFANLPNQVHR 28 1 Q15019;Q15019-3;C9JB25;C9J938;C9IZU3;C9JZI2;F8WB65;C9JFT1;A0A1B0GXJ2;C9JSE7;C9JT15 Q15019 SEPT2 Septin-2 1 73469700.0 9579700.0 28143000.0 35747000.0 True False 14533105.269880798 23120661.76773739 28681589.781533305 1.0 1.5908961875927448 1.9735348536265405 23.792839658910452 -8.559585538528152 0.11865691038040324 3.545454924079887e-18 2.9497508791943217 0.999955249867943 0.0026789174809392345 0.18221638594593256 0.03051651384633641 0.3810042272379036 0.3281231563567357 2.7568584087544013e-09 8.559585538528152 2.9497508791943217 (ac)SK(ub)QQPTQFINPETPGYVGFANLPNQVHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKQQPTQFINPETPGYVGFANLPNQVHR 28 1 Q15019;Q15019-3;C9JB25;C9J938;C9IZU3;C9JZI2;F8WB65;C9JFT1;A0A1B0GXJ2;C9JSE7;C9JT15 Q15019 SEPT2 Septin-2 1 49338000.0 11682000.0 19810000.0 17846000.0 True False 9714100.600348257 19703279.598022882 21577516.08941891 1.0 2.0283174334550855 2.2212572194944475 23.211648996479717 -10.697921068110272 0.33292930613463145 2.121194870860684e-11 2.263301882746315 0.9992002344980607 0.015159517063154814 2.327769878654756 0.16296692315413475 1.9467262818354976 0.060861598647753125 2.004836368037754e-11 10.697921068110272 2.263301882725103 (ac)SK(ub)QQPTQFINPETPGYVGFANLPNQVHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKQQPTQFINPETPGYVGFANLPNQVHR 28 1 Q15019;Q15019-3;C9JB25;C9J938;C9IZU3;C9JZI2;F8WB65;C9JFT1;A0A1B0GXJ2;C9JSE7;C9JT15 Q15019 SEPT2 Septin-2 1 69255700.0 9579700.0 25294000.0 34382000.0 True False 12401110.49411801 23886366.664787058 28124828.789111357 1.0 1.9261473943092948 2.2679282474300417 23.5639659810029 -10.243282785819446 0.22808773665192475 2.5988989084901272e-18 2.4937238020084482 0.9992346499260394 0.014818496819786853 1.8065285181251485 0.10917040716917263 1.2566484426883489 0.17421741455972004 5.711066461015013e-11 10.243282785819446 2.4937238020084482 (ac)SK(ub)SESPK(ub)EPEQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKSESPKEPEQLR 13 2 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 2 10617200.0 2294400.0 2158800.0 6164000.0 True False 2970146.0293855113 2038660.882262284 5042215.247980986 1.0 0.6863840572458517 1.6976321022923446 21.502102433242875 -6.823409437930988 1.3571078426271976 0.8315227069984793 1.7213563449253422 0.8920371384749048 0.1388718234630882 0.1890870908455307 0.6833482826105787 0.080394186001394 0.18514425451450484 1.5017255232294044e-07 6.823409437930988 0.8898336379268629 (ac)SK(ub)SESPKEPEQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKSESPKEPEQLR 13 2 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 36962000.0 11949000.0 13483000.0 11530000.0 True False 15665254.714280613 11471388.956322351 10336986.20356974 1.0 0.7322823130264784 0.6598671002870087 23.901064892078303 -13.999999999999998 0.18349836301869363 2.4043778961137847 0.6043747572459012 0.9994943329184462 0.003289626398518815 12.252077242475274 0.1358223661814921 6.140121400348682 0.05250247853423567 1.0000000000000041e-14 13.999999999999998 -1.8000031388678837 (ac)SK(ub)SESPKEPEQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKSESPKEPEQLR 13 2 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 69586000.0 16409000.0 24888000.0 28289000.0 True False 15888105.276832482 34825908.189205475 20879262.248191252 1.0 2.1919484785884116 1.3141442534772672 23.9214437517235 -10.24536701361577 4.97367889928818 0.9998671016600952 1.7530463660334425 0.4952722641669153 0.3583620742656704 0.000528197922305265 8.014030841698079e-05 0.3470429934170949 0.1156608621283085 5.683724076320908e-11 10.24536701361577 0.7531792643733474 (ac)SK(ub)SESPKEPEQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKSESPKEPEQLR 13 2 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 191721000.0 33020000.0 45921000.0 112780000.0 True False 50093754.0853539 37726038.76758942 90488983.56677008 1.0 0.75310863512662 1.8063925377320977 25.578127397136505 -6.844929304644771 1.259153615053857 0.868605878052143 1.8445880516859068 0.9326095840259064 0.11675858142303068 0.16313310982834797 0.5002486052250771 0.07264004413998097 0.16765240269330936 1.4291265757614877e-07 6.844929304644771 0.9759821736337638 (ac)SK(ub)SESPKEPEQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKSESPKEPEQLR 13 2 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 38218000.0 11949000.0 13885000.0 12384000.0 True False 16366868.209583353 13271514.78844519 9459154.256485973 1.0 0.8108768652926691 0.5779452816115009 23.964274953601194 -6.968325681457678 0.29545375632283416 1.042644104027847 0.3389261569843756 0.9999662173872369 0.0010032542648106017 0.07684981158965118 0.01096446945782446 0.003954269557427705 0.020993519924016837 1.075658264994772e-07 6.968325681457678 -0.7037179470434713 (ac)SK(ub)SESPKEPEQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKSESPKEPEQLR 13 2 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 65189000.0 16409000.0 34726000.0 14054000.0 True False 13644810.541954689 34538924.145428665 16992626.42164595 1.0 2.5312864578976257 1.2453545155059127 23.701849027157778 -6.603359669134066 2.178128834267598 2.0275930915616662 1.2496815607651008 0.030227914346827145 0.6613095802217078 0.6313006978169797 5.665290290805446 0.2515715931792296 0.7351305617570961 2.492529636694782e-07 6.603359669134066 -0.7779115307965654 (ac)SK(ub)SESPKEPEQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKSESPKEPEQLR 13 2 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 197261000.0 33020000.0 46221000.0 118020000.0 True False 42745040.92150875 43648760.718475536 96541570.98746206 1.0 1.0211420968955498 2.2585443575720987 25.349253719228955 -6.910607082214527 0.891574594265143 0.9624188708842651 2.420560459566941 0.9911489705154566 0.05535319172627185 0.104018481593346 0.13659410873253816 0.04545479319051722 0.12601247959351464 1.2285502306240407e-07 6.910607082214527 1.4581415886826758 up (ac)SK(ub)SFQQSSLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKSFQQSSLSR 11 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991;Q68E03;D6R8Z5;D6RCM3;D6REK4;D6RB45;A0A1B0GX04;D6RBS2;D6R9F3 P43243 MATR3;DKFZp686L22104 Matrin-3 1 12881400.0 3574700.0 4135200.0 5171500.0 True False 4686466.317444044 3518244.278883353 4636402.788530871 1.0 0.7507243284322102 0.9893174247883046 22.16006908314801 -10.631538171967001 8.589987810296513 1.0000888773285446 0.8700208766440793 0.2835155880747885 0.09740522370385532 0.00016590643869075937 7.116519901719864e-06 0.09437640218623115 0.03143740076988664 2.33594077754464e-11 10.631538171967001 -0.13006800068446522 (ac)SK(ub)SFQQSSLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKSFQQSSLSR 11 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991;Q68E03;D6R8Z5;D6RCM3;D6REK4;D6RB45;A0A1B0GX04;D6RBS2;D6R9F3 P43243 MATR3;DKFZp686L22104 Matrin-3 1 34746400.0 7959200.0 9704200.0 17083000.0 True False 7706539.552645814 13579137.666734448 12608449.820985232 1.0 1.762027895136469 1.6360715123633527 22.87765176527189 -10.094067050068492 4.415991249079576 0.9999344895372242 1.699049703702964 0.9762295464355083 0.05142147816150423 7544408.856785938 5748336.45982717 4518.181374462456 0.01760293919716377 8.052541096370331e-11 10.094067050068492 0.6991152141657397 (ac)SK(ub)SFQQSSLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKSFQQSSLSR 11 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991;Q68E03;D6R8Z5;D6RCM3;D6REK4;D6RB45;A0A1B0GX04;D6RBS2;D6R9F3 P43243 MATR3;DKFZp686L22104 Matrin-3 1 70051000.0 10957000.0 14552000.0 44542000.0 True False 16622570.06399824 11955081.904705063 35738254.17654784 1.0 0.7192077914953603 2.149983669128942 23.986640122849995 -6.855753860251449 1.2069022356195045 0.8490474481917034 2.213887070406095 0.9482737066313585 0.14078127676110017 0.15124627692583506 0.421051506767693 0.0911182671877465 0.2117949000795146 1.3939466091059284e-07 6.855753860251449 1.3648396222143915 up (ac)SK(ub)SFQQSSLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKSFQQSSLSR 11 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991;Q68E03;D6R8Z5;D6RCM3;D6REK4;D6RB45;A0A1B0GX04;D6RBS2;D6R9F3 P43243 MATR3;DKFZp686L22104 Matrin-3 1 15294500.0 3574700.0 4438200.0 7281600.0 True False 4896363.192635165 4242105.648835243 5561836.049259395 1.0 0.8663788779427107 1.135911661460326 22.2232791446709 -6.771935018810659 1.5673142735488563 0.9235471633168726 1.1375300394315289 0.7378100671780565 0.05634419818433188 0.2633134536789124 1.2768320532078212 0.028333311196179215 0.06731865603984043 1.6906938823141556e-07 6.771935018810659 0.21398287611465627 (ac)SK(ub)SFQQSSLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKSFQQSSLSR 11 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991;Q68E03;D6R8Z5;D6RCM3;D6REK4;D6RB45;A0A1B0GX04;D6RBS2;D6R9F3 P43243 MATR3;DKFZp686L22104 Matrin-3 1 36794200.0 7959200.0 17111000.0 11724000.0 True False 6618427.4523448 17018819.64673241 14175434.194348715 1.0 2.5714295078815015 2.141813035863465 22.658057040706165 -10.345258948386698 5.464154572218636 0.9996412001013164 2.3566212718725073 0.9300463379433158 0.17539019025656427 0.0007668110422902017 9.188222439913912e-05 0.16986222437667842 0.05660694049597299 4.51586605258816e-11 10.345258948386698 1.3569800717711908 (ac)SK(ub)SFQQSSLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKSFQQSSLSR 11 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991;Q68E03;D6R8Z5;D6RCM3;D6REK4;D6RB45;A0A1B0GX04;D6RBS2;D6R9F3 P43243 MATR3;DKFZp686L22104 Matrin-3 1 63934000.0 10957000.0 19388000.0 33589000.0 True False 14184052.494759863 18309040.75657829 27476146.652244233 1.0 1.2908187390974728 1.9371154091818952 23.757766444942444 -6.957932451540906 0.4636592091055894 0.9818344360249767 2.2723134404191985 0.9996856473053516 0.006943830903139582 0.08044819959785182 0.023924573041105738 0.008833316812301942 0.05337058047317413 1.10171065196666e-07 6.957932451540906 1.2904790043942218 (ac)SKPHSEAGTAFIQTQQLHAAMADTFLEHMCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKPHSEAGTAFIQTQQLHAAMADTFLEHMCR 31 1 P14618;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 15714200.0 5684900.0 6713200.0 3316100.0 False True 7452958.952649916 5711616.72784865 2972981.782277332 1.0 0.7663555863027894 0.398899524492924 22.829381883327898 -6.964458552370855 0.36722620763191566 1.0291613397745825 0.1233587116206746 0.9999015450996488 0.0024549721646836575 0.07814518036850047 0.015510717639012093 0.004864749746269234 0.031255055012720065 1.085279120140706e-07 6.964458552370855 -0.9058026281539079 down (ac)SKPHSEAGTAFIQTQQLHAAMADTFLEHMCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKPHSEAGTAFIQTQQLHAAMADTFLEHMCR 31 1 P14618;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 48377000.0 23515000.0 10437000.0 14425000.0 False True 22768529.19646025 14604548.528235964 10646659.759275982 1.0 0.6414357467809773 0.46760419469392794 24.440537763349337 -13.99999999999977 0.09538794103418219 2.7974317060396072 0.06939083582430641 0.9998165722405793 0.0030021685911015045 12.117158967653959 0.09101187500470534 4.3416531873779585 0.35621873806266663 1.0000000000005276e-14 13.99999999999977 -2.7280408702153007 (ac)SKPHSEAGTAFIQTQQLHAAMADTFLEHMCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKPHSEAGTAFIQTQQLHAAMADTFLEHMCR 31 1 P14618;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 67426900.0 3057000.0 58066000.0 6303900.0 False True 4637692.496636183 47703668.6282713 5057931.401902481 1.0 10.286078402755633 1.0906137924347306 22.144975734222854 -6.643893912816074 2.0304276118499973 7.054490371570588 1.129012654502344 0.16974933775514434 3.96937609114529 0.5235626778623206 4.129950619852864 1.5894017456633784 4.395604336594063 2.270419390321629e-07 6.643893912816074 -5.925477717068244 (ac)SKPHSEAGTAFIQTQQLHAAMADTFLEHMCR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SKPHSEAGTAFIQTQQLHAAMADTFLEHMCR 31 1 P14618;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 47256200.0 10919100.0 9826000.0 26511100.0 False True 14956186.347582333 9391854.829763224 20249724.1932433 1.0 0.6279578638227797 1.353936339293918 23.834239015985492 -6.767397399008253 1.5843263098921672 0.7858973513856237 1.357632105706763 0.7205299188689511 0.15669704136393015 0.27066413626853947 1.340380573372409 0.0779762094935027 0.18606922807060577 1.7084512897568675e-07 6.767397399008253 0.5717347543211394 (ac)SKPHSEAGTAFIQTQQLHAAMADTFLEHMCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKPHSEAGTAFIQTQQLHAAMADTFLEHMCR 31 1 P14618;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 56112600.0 23515000.0 3880600.0 28717000.0 False True 19553764.39113078 3859694.4375612047 34721591.927594036 1.0 0.1973888178437851 1.7756985935323584 24.220943038783613 -6.768473202535392 1.5804171486960459 0.5387470311050833 1.784043502920876 0.7246500402942153 0.33812725151571915 0.2689024854510445 1.325297076328235 0.16866703486905413 0.4020431030784639 1.7042244725881573e-07 6.768473202535392 1.2452964718157928 (ac)SKPHSEAGTAFIQTQQLHAAMADTFLEHMCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKPHSEAGTAFIQTQQLHAAMADTFLEHMCR 31 1 P14618;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 56173000.0 12104000.0 29834000.0 14235000.0 False True 15668866.605510045 28173711.673806313 11644376.06343436 1.0 1.7980695338805723 0.7431536917507199 23.90139749164507 -6.704375791122049 1.8150641319225294 1.4934384802644134 0.746005411471375 0.4383593626201402 0.33661536330436886 0.38654147337979905 2.478624942766091 0.14777913262291734 0.37803784171031274 1.9752597258978094e-07 6.704375791122049 -0.7474330687930384 (ac)SLK(ub)LQASNVTNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLKLQASNVTNK 12 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 14063500.0 3538700.0 6186500.0 4338300.0 True False 4639269.968819543 5263498.314788127 3889414.331912111 1.0 1.1345531409389866 0.8383677514033029 22.14546637139563 -6.783151416679273 1.523219012480021 1.0758732387470047 0.8357689734633296 0.7785301285588304 0.056983551961259135 0.2456925734959384 1.1260739777045425 0.029456953934352857 0.06933613737941643 1.6475878602171797e-07 6.783151416679273 -0.24010426528367512 (ac)SLK(ub)LQASNVTNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLKLQASNVTNK 12 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 21674300.0 5979400.0 8627300.0 7067600.0 True False 5789587.219958078 12072225.880775165 5216383.536544815 1.0 2.085161760610384 0.9009940326251076 22.465029061416374 -6.6657030264462405 1.9527743296717537 1.695206999625059 0.9058792443270638 0.26006986118673703 0.4614164602414144 0.4710694983422834 3.4589541616172608 0.19051544958351962 0.5118473474021488 2.1592203942072484e-07 6.6657030264462405 -0.7893277552979951 (ac)SLK(ub)LQASNVTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLKLQASNVTNK 12 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 9280100.0 3538700.0 2881700.0 2859700.0 True False 4847053.01977174 2754376.965492434 2184297.7573702326 1.0 0.5682580640766633 0.4506444943886949 22.208676432918523 -13.999999999999998 0.18248924424134322 3.2575400273296498 0.3595801992060345 0.9994953466239841 0.005305642436280432 12.2379156523677 0.13544075784365672 9.802020360545267 0.08599120701223784 1.0000000000000041e-14 13.999999999999998 -2.897959828123615 (ac)SLK(ub)LQASNVTNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLKLQASNVTNK 12 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 16808100.0 5979400.0 7963100.0 2865600.0 True False 4972136.032333709 7920201.199748398 3464783.7109626136 1.0 1.5929172388372874 0.696840088129365 22.24543433685065 -6.728282841014248 1.7295270148021906 1.3574939797152479 0.6975406288071277 0.5512878854218795 0.24928335843963617 0.3394579800765982 1.988486229181577 0.1142587896048953 0.28407442005706646 1.8694642262562969e-07 6.728282841014248 -0.6599533509081201 (ac)SLK(ub)LQASNVTNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLKLQASNVTNK 12 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 15291600.0 3486900.0 4699100.0 7105600.0 True False 4513860.787074762 4437590.954159124 5812453.709612864 1.0 0.9831031933607626 1.2876900692765192 22.105930494080344 -6.893774823558465 0.9998010359483376 0.9850841992030437 1.3159082801249335 0.983205918425967 0.018113243727313696 0.11613320477577259 0.20439227238564586 0.013731292612208445 0.03473129381980992 1.2771007985132343e-07 6.893774823558465 0.33082408092188986 (ac)SLLNK(ub)PK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLLNKPK 7 1 P62316;K7ERG4 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 1 8119250.0 3023800.0 4350900.0 744550.0 True False 2514423.677052994 4327460.838113968 900231.9625897588 1.0 1.7210547600259345 0.35802715779580435 21.261796331765215 -6.762961923775159 1.6011865531545837 1.417277374674136 0.35228009848702757 0.7030064101887404 0.3034213129698522 0.2779623181601501 1.4051481098214447 0.1494654014007017 0.35816566153486434 1.725989209299325e-07 6.762961923775159 -1.0649972761871085 (ac)SLLNKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLNKPK 7 1 P62316;K7ERG4 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 18988500.0 5750300.0 1843200.0 11395000.0 False True 5567759.874055086 2579199.372161017 8410307.657327557 1.0 0.4632382556905325 1.5105370647391443 22.40866556140518 -6.767390471768721 1.584424020649069 0.6911012038012418 1.5158573907200552 0.7204783120588134 0.22607269926128276 0.2706746663674408 1.3406085808754413 0.1124940174826732 0.26843066110652125 1.7084785407264128e-07 6.767390471768721 0.8247561869188134 (ac)SLLNKPK(ub)SEMTPEELQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLNKPKSEMTPEELQK 17 2 P62316;K7ERG4 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 1 18349100.0 8266200.0 6196200.0 3886700.0 True False 8003794.005689115 8670374.97275614 2868656.671499341 1.0 1.0832831238026888 0.3584121067409147 22.932252606283583 -6.878303272146698 1.0891746214737612 1.0505504837699233 0.30867477983822705 0.9722928066100578 0.05390922644341785 0.1291457221086123 0.2814340101001701 0.03818271585919901 0.09195377737069989 1.3234170571813843e-07 6.878303272146698 -0.7418757039316963 down (ac)SLLNKPK(ub)SEMTPEELQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLLNKPKSEMTPEELQK 17 2 P62316;K7ERG4 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 1 33336400.0 15202000.0 7804400.0 10330000.0 True False 23062545.41506814 6411643.843944481 8288270.972200158 1.0 0.27801110972578813 0.3593823154830488 24.45904841636144 -10.571967149356368 6.426890992731676 1.0012089824932486 0.31869671261800275 0.989414772396564 0.03321965564338491 0.0005762996148114223 3.8381726143638326e-05 0.032211519203927175 0.01072159775613124 2.6793709885329656e-11 10.571967149356368 -0.6825122698752459 (ac)SLLNKPK(ub)SEMTPEELQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLLNKPKSEMTPEELQK 17 2 P62316;K7ERG4 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 1 12589700.0 4516700.0 4981700.0 3091300.0 True False 6186646.049227976 4761592.021721092 2361198.607321958 1.0 0.7696564477476912 0.3816605295556886 22.560726066079877 -6.963259177031133 0.3867739916848494 1.0247027329667906 0.1127450742885386 0.9998726303754341 0.0028796411790935313 0.07855684376788478 0.0169749058165306 0.005019755969154157 0.03268314717690166 1.0882804385846631e-07 6.963259177031133 -0.911957658678252 down (ac)SLLNKPK(ub)SEMTPEELQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLLNKPKSEMTPEELQK 17 2 P62316;K7ERG4 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 1 36561800.0 15202000.0 12563000.0 8796800.0 True False 19679288.676219746 11863858.006235445 7195872.662790269 1.0 0.6028601034025997 0.36565715261272064 24.23017473845389 -8.954499829790251 0.16005163654719157 1.4700695261104102 6.089284387425849e-10 0.9998117563154449 0.003590552793426425 0.43446343816344496 0.05068502770532683 0.2609663816960678 0.16153006956440813 1.1104529705449824e-09 8.954499829790251 -1.4700695255014817 (ac)SLPLNPK(ub)PFLNGLTGK(ub)PVMVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLPLNPKPFLNGLTGKPVMVK 21 2 P62306;A0A0B4J254;F8W0W6 P62306 SNRPF Small nuclear ribonucleoprotein F 2 7719000.0 1467700.0 4073400.0 2177900.0 True False 1421108.6668783615 5699929.862500372 1607442.654400498 1.0 4.010903596148607 1.131118746838299 20.43858544563072 -6.63575304612875 2.059848482755264 2.9752545428980697 1.142981808156775 0.13853403145060028 1.2896485658603667 0.5441402032154838 4.407172643822684 0.5107959896621219 1.4281017016989168 2.3133798787664785e-07 6.63575304612875 -1.8322727347412946 (ac)SLPLNPK(ub)PFLNGLTGKPVMVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLPLNPKPFLNGLTGKPVMVK 21 2 P62306;A0A0B4J254;F8W0W6 P62306 SNRPF Small nuclear ribonucleoprotein F 1 13786500.0 6551900.0 4832400.0 2402200.0 True False 6343913.520828736 6762002.520633081 1772991.7555447328 1.0 1.0659039563562223 0.27947918106442254 22.596941673921883 -6.886551992912758 1.0426041319080526 1.0458142624436784 0.21624746737166992 0.9785965006650653 0.05211300380965709 0.12198363804354133 0.23856732362702895 0.03824780972710957 0.09423897719832745 1.2985180983961734e-07 6.886551992912758 -0.8295667950720085 down (ac)SLPLNPKPFLNGLTGK(ub)PVMVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLPLNPKPFLNGLTGKPVMVK 21 2 P62306;A0A0B4J254;F8W0W6 P62306 SNRPF Small nuclear ribonucleoprotein F 1 14696600.0 6183500.0 3796500.0 4716600.0 True False 5987208.177176779 5312462.248485948 3481180.9650330096 1.0 0.8873020765733584 0.5814364328107484 22.51345200341308 -6.953678543515352 0.5168857375914114 1.0053253870703307 0.4498358124203134 0.9994592316996669 0.004112298332462197 0.0820414163524309 0.03010317554661417 0.004682147068402063 0.025257305420892166 1.112554914498867e-07 6.953678543515352 -0.5554895746500172 (ac)SLPLNPKPFLNGLTGK(ub)PVMVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLPLNPKPFLNGLTGKPVMVK 21 2 P62306;A0A0B4J254;F8W0W6 P62306 SNRPF Small nuclear ribonucleoprotein F 1 6268300.0 1186600.0 2312700.0 2769000.0 True False 1625318.086659267 2210517.266923813 2115019.229345097 1.0 1.3600520938442173 1.3012955720516088 20.63229066108848 -10.073352689952914 4.323816425895688 0.99996783626648 1.3306738329909773 0.9768681824871964 0.02398724972296167 8326572.854466911 0.14151064313163988 2699.5824626208027 0.008211473581801782 8.445926740268623e-11 10.073352689952914 0.3307059967244973 (ac)SLPLNPKPFLNGLTGK(ub)PVMVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLPLNPKPFLNGLTGKPVMVK 21 2 P62306;A0A0B4J254;F8W0W6 P62306 SNRPF Small nuclear ribonucleoprotein F 1 12744000.0 6183500.0 3427800.0 3132700.0 True False 5141854.225496795 3409333.761034969 3787733.086031755 1.0 0.6630553126397835 0.7366473104681983 22.293857278847355 -9.904702584847936 5.320832667644745 1.0000004461102303 0.6998513115514262 0.9568583057285366 0.030043807314258566 1.5899591763680632e-07 3.274978587600629e-08 0.02908983468861366 0.009696597114101257 1.2453671767620477e-10 9.904702584847936 -0.3001491345588041 (ac)SLPLNPKPFLNGLTGKPVMVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLPLNPKPFLNGLTGKPVMVK 21 2 P62306;A0A0B4J254;F8W0W6 P62306 SNRPF Small nuclear ribonucleoprotein F 0 13273900.0 2463800.0 7738600.0 3071500.0 False True 3230065.6594731384 6584031.044826534 2753690.643908449 1.0 2.0383582685128654 0.8525184730633644 21.62313206106489 -6.675408821847792 1.9184693791385532 1.6596932072075665 0.8572147601962476 0.3030635472938845 0.4405338399093583 0.44884150482924323 3.189858200485136 0.18454047609726837 0.48954645753069304 2.1115004491979994e-07 6.675408821847792 -0.8024784470113189 (ac)SLPLNPKPFLNGLTGKPVMVK ddPTM_RPMI8226_Bortezomib_2h_R1 2 SLPLNPKPFLNGLTGKPVMVK 21 2 P62306;A0A0B4J254;F8W0W6 P62306 SNRPF Small nuclear ribonucleoprotein F 0 112809400.0 55245200.0 24749400.0 32814800.0 False True 53491471.36569358 34631964.48641599 24219619.457101546 1.0 0.647429648170549 0.45277534602711733 25.67280555200094 -10.775339592106365 0.10769662044598668 1.9453632570908679 6.892416525957636e-14 0.999875743878527 0.0025246046846335232 2.8675203610050537 0.06156215759832655 0.9695416961615814 0.2839817785174955 1.6774918076772458e-11 10.775339592106365 -1.945363257090799 (ac)SLPLNPKPFLNGLTGKPVMVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLPLNPKPFLNGLTGKPVMVK 21 2 P62306;A0A0B4J254;F8W0W6 P62306 SNRPF Small nuclear ribonucleoprotein F 0 91472800.0 5657800.0 75810000.0 10005000.0 False True 8583296.24058494 62281113.193766505 8027507.364652715 1.0 7.2560833796320345 0.9352476181231805 23.033100361187426 -6.648659555031581 2.014870460253096 5.064156623728945 0.9625746345013403 0.18815847713318268 2.6711047122609495 0.5117281272798072 3.981030507892947 1.0761312447153089 2.955613575512746 2.2456416003153927e-07 6.648659555031581 -4.101581989227604 (ac)SLPLNPKPFLNGLTGKPVMVK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SLPLNPKPFLNGLTGKPVMVK 21 2 P62306;A0A0B4J254;F8W0W6 P62306 SNRPF Small nuclear ribonucleoprotein F 0 104412800.0 6381100.0 29980700.0 68051000.0 False True 8740365.112743525 28656053.541083045 51978755.35433836 1.0 3.278587698733807 5.946977578608577 23.05926211625169 -6.969044296175677 0.2800718665752695 0.4126494930874477 8.894235498953178 0.9999739395720632 0.010320576678612562 0.07661402953463571 0.010135302989049343 0.049267943661349664 0.2449024761065432 1.0738798756107628e-07 6.969044296175677 8.48158600586573 (ac)SLPLNPKPFLNGLTGKPVMVK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SLPLNPKPFLNGLTGKPVMVK 21 2 P62306;A0A0B4J254;F8W0W6 P62306 SNRPF Small nuclear ribonucleoprotein F 0 82345700.0 55245200.0 11894400.0 15206100.0 False True 45938831.577329226 11830322.506346462 18385625.204937384 1.0 0.2575233653131203 0.40021969592301676 25.453210827435218 -9.95985246292482 6.9219303640116285 1.0000000423620252 0.3288715306562762 0.9672059894660188 0.05825553302696387 3.8059810357587827e-08 5.707075447162709e-09 0.056405680671477644 0.01880189243648783 1.0968507513427003e-10 9.95985246292482 -0.671128511705749 (ac)SLPLNPKPFLNGLTGKPVMVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLPLNPKPFLNGLTGKPVMVK 21 2 P62306;A0A0B4J254;F8W0W6 P62306 SNRPF Small nuclear ribonucleoprotein F 0 22945000.0 5657800.0 8592200.0 8695000.0 False True 7324133.631911318 8114036.51684918 7112599.218234049 1.0 1.1078493272564345 0.9711181657369533 22.804226683279875 -6.696453975545064 1.843751982159257 1.0672035666034072 0.9715544125114831 0.40061816659868876 0.04555505353465995 0.40296751659675395 2.6606993016644886 0.019731242009865 0.05096237593609791 2.01162036882419e-07 6.696453975545064 -0.0956491540919241 (ac)SLSDWHLAVK(ub)LADQPLTPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLSDWHLAVKLADQPLTPK 19 1 Q96S82;H3BV23;H3BUV9 Q96S82 UBL7 Ubiquitin-like protein 7 1 27851400.0 6980400.0 5584000.0 15287000.0 True False 6758811.022877783 7813720.320175304 11282876.099830296 1.0 1.156079123047941 1.6693581255104017 22.688338046265734 -6.949369536291471 0.5657211413656745 0.9934773325002686 1.8567325425899852 0.9991508862927883 0.00833216921352112 0.0837398677118852 0.03701748971385643 0.008871126072377904 0.04272246092492424 1.1236484672376887e-07 6.949369536291471 0.8632552100897166 (ac)SLSDWHLAVK(ub)LADQPLTPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLSDWHLAVKLADQPLTPK 19 1 Q96S82;H3BV23;H3BUV9 Q96S82 UBL7 Ubiquitin-like protein 7 1 42376000.0 14913000.0 13388000.0 14075000.0 True False 22624111.28633804 10998806.79907857 11293070.08070834 1.0 0.48615420335738846 0.49916082615487556 24.431357785999648 -9.996453303508082 5.594224216503134 1.0000012337750568 0.49265751475573377 0.9995073092841961 0.005309931523187231 8.1705028059684e-08 1.4667171935318561e-08 0.005141331575460116 0.0017137730296963446 1.0082000078692754e-10 9.996453303508082 -0.5073437190193231 (ac)SLSDWHLAVK(ub)LADQPLTPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLSDWHLAVKLADQPLTPK 19 1 Q96S82;H3BV23;H3BUV9 Q96S82 UBL7 Ubiquitin-like protein 7 1 20420600.0 6980400.0 9482400.0 3957800.0 True False 5804511.884152634 9431316.42909097 4785357.681200391 1.0 1.6248250701045452 0.8244203434685493 22.46874332170001 -6.698379244894442 1.8363261839822114 1.388591408533515 0.8268445938782862 0.4100805596080538 0.2638233875181366 0.3988796601526864 2.613767976779669 0.1146578490040291 0.29549653610820525 2.0027223989517581e-07 6.698379244894442 -0.5617468146552287 (ac)SLSDWHLAVK(ub)LADQPLTPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLSDWHLAVKLADQPLTPK 19 1 Q96S82;H3BV23;H3BUV9 Q96S82 UBL7 Ubiquitin-like protein 7 1 47542000.0 14913000.0 12674000.0 19955000.0 True False 19305172.479178056 11968680.758658607 16323394.75559062 1.0 0.6199727441734926 0.8455451394281255 24.202484108092097 -10.272977629661675 5.6117734110489454 1.000022234039643 0.7327589418008036 0.6517412634764478 0.09208954473856186 2.5619273419566424e-05 3.3190382920564872e-06 0.08917272923227593 0.029721772761019966 5.333623680663265e-11 10.272977629661675 -0.2672632922388394 (ac)SNLSK(ub)GTGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNLSKGTGSR 10 1 Q13618;Q13618-3 Q13618 CUL3 Cullin-3 1 5395380.0 855880.0 1828700.0 2710800.0 True False 828710.5578850253 2558909.446544516 2000760.1577431774 1.0 3.0878204967910365 2.4143051379113256 19.660508776859274 -10.097285944484296 5.353051323081585 0.9999742351833255 2.7510628173523903 0.9001252379390163 0.27496149386803703 8.45496519801687e-05 1.4256939234926222e-05 0.26623420966243966 0.08874344054932232 7.99307808258184e-11 10.097285944484296 1.7510885821690647 (ac)SRPSSTGPSANK(ub)PCSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SRPSSTGPSANKPCSK 16 2 O43255 O43255 SIAH2 E3 ubiquitin-protein ligase SIAH2 1 2480610.0 509580.0 1126700.0 844330.0 True False 668064.3147797394 958600.7518422008 756966.830985259 1.0 1.4348929147012608 1.1330747867214412 19.349627472566294 -10.183531624874254 8.531902192897096 0.9999999693577305 1.283983850711351 0.5413720894751922 0.12321673477876476 7.192408560048263e-08 7.084490102137389e-09 0.11930410466516689 0.03976803014768434 6.553425627294256e-11 10.183531624874254 0.2839838813536205 (ac)SRPSSTGPSANK(ub)PCSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SRPSSTGPSANKPCSK 16 2 O43255 O43255 SIAH2 E3 ubiquitin-protein ligase SIAH2 1 2287200.0 806770.0 618240.0 862190.0 True False 781159.5279535704 865106.4560790097 636356.573854431 1.0 1.1074645128445888 0.8146307522120553 19.57525767925135 -6.807359718423174 1.4254514357276957 1.0587526715149944 0.8098039440057342 0.8528639439076374 0.04639471452689302 0.21041988754975446 0.8431303623823985 0.02559502067949023 0.059284650605163136 1.5582612879449075e-07 6.807359718423174 -0.24894872750926023 (ac)SRPSSTGPSANK(ub)PCSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SRPSSTGPSANKPCSK 16 2 O43255 O43255 SIAH2 E3 ubiquitin-protein ligase SIAH2 1 3832650.0 713950.0 1256700.0 1862000.0 True False 1083114.3467364754 1032432.0663580849 1493974.883856409 1.0 0.95320689774713 1.3793325592610741 20.0467541287629 -6.879670267473776 1.0815987386305967 0.9711205831407983 1.4093460716959896 0.9734201302409313 0.031107904866203608 0.12792431338962934 0.27403353920760953 0.0221612254822814 0.053548600669857546 1.319257988155761e-07 6.879670267473776 0.4382254885551913 (ac)SRPSSTGPSANK(ub)PCSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SRPSSTGPSANKPCSK 16 2 O43255 O43255 SIAH2 E3 ubiquitin-protein ligase SIAH2 1 1912950.0 509580.0 686000.0 717370.0 True False 697985.4968817035 655690.25170136 547941.9806989133 1.0 0.9394038337912459 0.7850334758342121 19.412837534089185 -6.955056784754345 0.5002596199141673 1.0030846127296627 0.714691638492292 0.9995406809189368 0.0019395690824434905 0.08151652188635755 0.02803395349453533 0.0022735050222409798 0.012734270189795638 1.1090297982185143e-07 6.955056784754345 -0.28839297423737065 (ac)SSACDAGDHYPLHLLVWK(ub)NDYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSACDAGDHYPLHLLVWKNDYR 22 1 Q8IZ07 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 43520300.0 9533300.0 21822000.0 12165000.0 True False 12498248.620608523 18566242.66148978 10906282.494919842 1.0 1.485507547903605 0.8726248633697631 23.575222608427843 -6.695579385248121 1.8464819387329574 1.302776788616953 0.8745838849664658 0.39667290939379696 0.20510926261238596 0.40480441467864786 2.6800148633078402 0.08872123150783193 0.22943385864867163 2.0156754890670702e-07 6.695579385248121 -0.42819290365048723 (ac)SSACDAGDHYPLHLLVWK(ub)NDYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSACDAGDHYPLHLLVWKNDYR 22 1 Q8IZ07 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 131258000.0 49243000.0 53696000.0 28319000.0 True False 74705231.14552027 44113529.27123708 22721737.23734137 1.0 0.5905012084803966 0.30415188988681535 26.154705933778406 -8.11915440601392 0.22200372102439406 1.2286968441690396 9.522119305394383e-18 0.9997144043991744 0.004825803262249473 0.08989985064382501 0.043817706958133994 0.0874250853715412 0.10548360776677247 7.600560039170028e-09 8.11915440601392 -1.2286968441690396 down (ac)SSACDAGDHYPLHLLVWK(ub)NDYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSACDAGDHYPLHLLVWKNDYR 22 1 Q8IZ07 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 46540300.0 9533300.0 20750000.0 16257000.0 True False 13058018.637745488 19833196.388925977 12417431.423424784 1.0 1.5188518977600607 0.9509430004588121 23.638432669950735 -6.666343077169482 1.9499303204907472 1.332226237334743 0.9532578180368508 0.2629161816103023 0.22058680569951597 0.46970234583949205 3.4393350889023484 0.09117782597948254 0.24480803308092744 2.1560405410226704e-07 6.666343077169482 -0.37896841929789227 (ac)SSACDAGDHYPLHLLVWK(ub)NDYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSACDAGDHYPLHLLVWKNDYR 22 1 Q8IZ07 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 46185000.0 19955000.0 12438000.0 13792000.0 True False 16593466.656390136 12370994.025250316 16675843.432997053 1.0 0.7455340274231517 1.0049644102894675 23.9841119854369 -11.007383942077446 10.262011929069713 1.1485310979937298 0.8752492188317027 0.2356534984952584 0.10591201029955889 0.06016528907310212 4.329143623155761e-05 0.017142750336717708 0.03418295433779498 9.831415660067353e-12 11.007383942077446 -0.27328187916202706 (ac)SSACDAGDHYPLHLLVWK(ub)NDYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSACDAGDHYPLHLLVWKNDYR 22 1 Q8IZ07 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 123097000.0 49243000.0 51323000.0 22531000.0 True False 63746034.224647276 48466829.93345719 18430589.18758269 1.0 0.7603112965844326 0.2891252673481065 25.925832255870855 -6.960380540454408 0.4300371957604467 1.0187088466406873 0.012657396524179715 0.9997840529446925 0.0043394453401319555 0.07956546774301095 0.02063111283648358 0.006144368757304854 0.03912268427757284 1.0955178533871314e-07 6.960380540454408 -1.0060514501165077 down (ac)SSEAETQQPPAAPPAAPALSAADTK(ub)PGTTGSGAGSGGPGGLTSAAPAGGDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKK 52 2 P67809;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 34065000.0 10325000.0 10609000.0 13131000.0 True False 13536174.987442227 9026178.553558096 11772330.081446173 1.0 0.6668189914752032 0.8696939934928141 23.69031678818713 -10.334673639624938 5.6670842857377535 1.0000393139801549 0.7682564924840071 0.6350085127667169 0.08282337275154797 4.114670888228674e-05 4.830595361131957e-06 0.08020696873288904 0.026731128611955396 4.6272861862587086e-11 10.334673639624938 -0.23178282149614782 (ac)SSEAETQQPPAAPPAAPALSAADTK(ub)PGTTGSGAGSGGPGGLTSAAPAGGDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKK 52 2 P67809;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 44031400.0 10325000.0 19212400.0 14494000.0 True False 14142431.52263352 18363532.641089223 11070815.713300051 1.0 1.2984706775281365 0.7828085075457031 23.75352684971002 -6.7497610001423665 1.650606657999557 1.1755536276386738 0.781794829309074 0.647985614656156 0.12541825179782287 0.30046546126607326 1.6105388329051247 0.060023795983120645 0.14576514487135428 1.779258297659693e-07 6.7497610001423665 -0.3937587983295998 (ac)SSEAETQQPPAAPPAAPALSAADTK(ub)PGTTGSGAGSGGPGGLTSAAPAGGDKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKK 52 2 P67809;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 49189700.0 16080000.0 18657000.0 14452700.0 True False 13371232.464783447 18556491.037875447 17474692.74826543 1.0 1.387792119144492 1.3068872143453862 23.67262911310456 -10.134425491983993 4.601409026654831 0.9999638679978146 1.347339666751206 0.9608996843140958 0.03302928909577382 1.2244151154855163e-05 2.303252507599152e-06 0.03198379344642494 0.010660157214065678 7.337945941888548e-11 10.134425491983993 0.34737579875339153 (ac)SSEAETQQPPAAPPAAPALSAADTK(ub)PGTTGSGAGSGGPGGLTSAAPAGGDKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKK 52 2 P67809;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 132222300.0 36820000.0 85461000.0 9941300.0 True False 47664215.83070713 80705020.22374344 8132085.406351944 1.0 1.6931993701604158 0.1706119625514313 25.5064032256656 -6.782903876929598 1.5243511939745134 1.391025426866201 0.15738992523682327 0.7775951021989471 0.293533117524761 0.2460896447397734 1.1295872177353248 0.15163220281327885 0.3569607202343881 1.648527222233411e-07 6.782903876929598 -1.2336355016293776 (ac)SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKK 52 2 P67809;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 46613900.0 2597600.0 16567200.0 27449100.0 True False 3405478.7551941816 14095438.338439804 24608930.442359615 1.0 4.139047503068648 7.2262763069142695 21.699426201391685 -7.240929371198908 0.25988551903049356 7.537814782311e-16 10.62616656996305 0.9999465092985111 0.018590749703567288 0.1030568314764612 0.01574870537274327 0.12979332065126434 0.43560577544197077 5.742098376852868e-08 7.240929371198908 10.62616656996305 (ac)SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKK 52 2 P67809;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 96409000.0 20202900.0 21612100.0 54594000.0 True False 19561569.998008378 30241924.23561259 40294193.61510666 1.0 1.5459865562269088 2.0598650118170028 24.22151882884952 -6.97185763683907 0.20910918525003241 0.7278782290506765 2.892304561978126 0.9999934750400411 0.001105412450114853 0.07570437696173526 0.006829395242558016 0.01549768829499557 0.053360546859353625 1.066945812261994e-07 6.97185763683907 2.16442633292745 (ac)SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKK 52 2 P67809;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 179473700.0 38662700.0 92992000.0 47819000.0 True False 58654142.5219809 76396851.05018768 38367553.69018773 1.0 1.302497108734607 0.6541320363827554 25.805729668200502 -6.779836799445501 1.5364704102362612 1.1713185788320566 0.6490194207103829 0.7668156300643341 0.1279137841227797 0.25083288338837584 1.169598698030211 0.06557101431184673 0.15474351052910837 1.66021066944879e-07 6.779836799445501 -0.5222991581216737 (ac)SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKK 52 2 P67809;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 62745600.0 2597600.0 23876400.0 36271600.0 True False 3558002.9175005164 22821461.69930372 27704995.117050737 1.0 6.41412113156324 7.786670151612296 21.762636262914576 -9.261292892668065 0.4689925227559245 1.6451861796664098e-13 7.845060260927221 0.9977506857665986 0.13895317891908843 0.6422478353124423 0.19016028280589084 1.5605676903076557 0.29391459160312855 5.479073259513828e-10 9.261292892668065 7.845060260927057 (ac)SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKK 52 2 P67809;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 45451800.0 20202900.0 19776000.0 5472900.0 True False 16799606.490222245 19669462.762771364 6617258.08616949 1.0 1.1708287794847718 0.39389363614087536 24.001924104283795 -6.849059184627794 1.2395141246891033 1.0910986611826794 0.3633763936762598 0.9389350124275763 0.08237833527694438 0.15849982969358095 0.4690685154694712 0.05201522830050728 0.12030410451413039 1.415600852065802e-07 6.849059184627794 -0.7277222675064197 down (ac)SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKK 52 2 P67809;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 211815700.0 38662700.0 90338000.0 82815000.0 True False 50049627.305754505 85310610.88651589 67743519.75365756 1.0 1.7045204026265988 1.3535269571501622 25.57685599029295 -10.095547487576614 4.476257039930592 0.9999588126845984 1.5290236797234664 0.7517958761551513 0.14329247421330535 49849986.6467656 2.25626146919261 24305.469071066524 0.04905282525925107 8.025138058560987e-11 10.095547487576614 0.529064867038868 (ac)SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSEAETQQPPAAPPAAPALSAADTKPGTTGSGAGSGGPGGLTSAAPAGGDKK 52 2 P67809;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 0 35771500.0 1326400.0 3200700.0 31244400.0 False True 1284294.158034653 4478756.201430004 23060554.328091692 1.0 3.487328952958733 17.955819688054262 20.29254424821238 -6.936494288512727 0.6914066691570613 0.8236206218278335 21.485517044623368 0.9976677459461959 0.361044690186823 0.08940295431342453 0.062168992046355204 0.34273290295392395 1.2656978797245775 1.1574592539534472e-07 6.936494288512727 20.661896422795536 (ac)SSEPPPPYPGGPTAPLLEEK(ub)SGAPPTPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSEPPPPYPGGPTAPLLEEKSGAPPTPGR 29 1 Q9H305-3;Q9H305-2;Q9H305;K7ESA8;H3BTN7;K7ELR4 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 1 54078900.0 13829900.0 19365900.0 20883100.0 True False 18131132.828942098 16476583.207686957 18722317.136840165 1.0 0.9087453808394123 1.0326060325891155 24.111965731358676 -6.709330530526867 1.7978037678830006 0.9438584975950695 1.0323062374470904 0.4617712221457786 0.03845846926362221 0.37645065569957564 2.3714293730667046 0.01702693484329136 0.04328812154012211 1.9528526233978522e-07 6.709330530526867 0.08844773985202092 (ac)SSEPPPPYPGGPTAPLLEEK(ub)SGAPPTPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSEPPPPYPGGPTAPLLEEKSGAPPTPGR 29 1 Q9H305-3;Q9H305-2;Q9H305;K7ESA8;H3BTN7;K7ELR4 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 1 59460400.0 16928700.0 20631100.0 21900600.0 True False 16391307.684801904 28869205.819765184 16164175.856083177 1.0 1.7612509248748252 0.9861431538540806 23.96642762024265 -10.216994741142559 4.312407150702427 0.9998447977851713 1.3736970393421657 0.23659637488015672 0.3164364224881431 222818590.8344505 98.31687562285543 347350.13074134884 0.10832460412662702 6.06743676583029e-11 10.216994741142559 0.37385224155699437 (ac)SSEPPPPYPGGPTAPLLEEK(ub)SGAPPTPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSEPPPPYPGGPTAPLLEEKSGAPPTPGR 29 1 Q9H305-3;Q9H305-2;Q9H305;K7ESA8;H3BTN7;K7ELR4 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 1 101442000.0 38845000.0 45497000.0 17100000.0 True False 58930704.9498962 37377704.880316496 13720177.504803749 1.0 0.6342653615308963 0.23281882537242438 25.812516188531657 -7.4695623256125945 0.3542229555885369 1.0549423200376808 1.200010991935344e-12 0.9994308701829695 0.007474542884114609 0.1193962874227352 0.037723960070882814 0.018777909323765593 0.06355717728290979 3.3918580948399073e-08 7.4695623256125945 -1.054942320036481 down (ac)SSEPPPPYPGGPTAPLLEEK(ub)SGAPPTPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSEPPPPYPGGPTAPLLEEKSGAPPTPGR 29 1 Q9H305-3;Q9H305-2;Q9H305;K7ESA8;H3BTN7;K7ELR4 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 1 49782600.0 13829900.0 16956300.0 18996400.0 True False 18943187.7689946 16207114.59901424 14509841.563138738 1.0 0.855564269153334 0.7659662006247875 24.175175792881568 (ac)SSEPPPPYPGGPTAPLLEEK(ub)SGAPPTPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSEPPPPYPGGPTAPLLEEKSGAPPTPGR 29 1 Q9H305-3;Q9H305-2;Q9H305;K7ESA8;H3BTN7;K7ELR4 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 1 52828000.0 16928700.0 22590600.0 13308700.0 True False 14076964.118568389 22468899.95391697 16091487.637523783 1.0 1.5961467092381871 1.1431078108878685 23.746832895676928 -10.24718787608103 5.369762735447953 0.999966477106077 1.3696272600630648 0.47021437807608246 0.18495235576527874 7.423294146500386e-05 1.0407221262292145e-05 0.1790955590430727 0.05969311614337744 5.659943865224245e-11 10.24718787608103 0.3696607829569878 (ac)SSEPPPPYPGGPTAPLLEEK(ub)SGAPPTPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSEPPPPYPGGPTAPLLEEKSGAPPTPGR 29 1 Q9H305-3;Q9H305-2;Q9H305;K7ESA8;H3BTN7;K7ELR4 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 1 91493000.0 38845000.0 36928000.0 15720000.0 True False 50285618.24942482 34872924.3376791 12859121.300821075 1.0 0.6934969788917329 0.2557216506126612 25.583642510624106 -7.195077670576589 0.3879502568084527 1.0326257610614824 6.859810577363275e-13 0.9997375416243321 0.004948001000164363 0.08797652561499104 0.0237402603713296 0.008714803194726986 0.04313281767011968 6.381493473692932e-08 7.195077670576589 -1.0326257610607965 down (ac)SSGIHVALVTGGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSGIHVALVTGGNK 14 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 61797000.0 19324000.0 20949000.0 21524000.0 False True 25333951.13388222 17823490.85856243 19296902.952787094 1.0 0.7035416925046829 0.7617012778941917 24.594568764425038 -10.713908922387262 6.808778039849911 1.0030143651473662 0.7326214851994388 0.9657305716933762 0.023743551309354044 0.0010962604283688948 4.6062574541252526e-05 0.023197035463304254 0.007663198233412457 1.9323735202174204e-11 10.713908922387262 -0.2703928799479274 (ac)SSGIHVALVTGGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSGIHVALVTGGNK 14 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 55942800.0 16689000.0 9150800.0 30103000.0 False True 16159216.830096751 12804762.160791595 22218121.22935772 1.0 0.7924122991494587 1.3749503743260738 23.94585394257876 -6.810343702065258 1.4129538916956528 0.8869119492307842 1.3852354007895171 0.8607587145998666 0.08995524495897037 0.20632957986483255 0.8117823291741834 0.05005747693537725 0.11578253959853703 1.547591365302482e-07 6.810343702065258 0.4983234515587329 (ac)SSGIHVALVTGGNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSGIHVALVTGGNK 14 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 138901000.0 33424000.0 60120000.0 45357000.0 False True 50706651.621710144 49391116.28029599 36392169.06932068 1.0 0.9740559611147563 0.7177001025589177 25.595671674402993 -6.926391668541691 0.7758372242921767 1.004463847695188 0.6696016021282114 0.9957803172258637 0.008276006743846522 0.09455522285624947 0.08717929497410352 0.007383867305685837 0.02367266510126324 1.1846998445170091e-07 6.926391668541691 -0.3348622455669765 (ac)SSGIHVALVTGGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSGIHVALVTGGNK 14 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 82882000.0 19324000.0 22343000.0 41215000.0 False True 26468605.011464458 21355812.381579444 31480865.84956954 1.0 0.8068355839807013 1.1893662637654723 24.65777882594793 -6.7694374354121445 1.5767743087723716 0.8891257402324957 1.1914637240350765 0.7283454008003467 0.08139660911249022 0.2673395807118058 1.311680763301306 0.040693433479945494 0.09691075165959519 1.7004449025795077e-07 6.7694374354121445 0.3023379838025808 (ac)SSGIHVALVTGGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSGIHVALVTGGNK 14 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 34026800.0 16689000.0 7974300.0 9363500.0 False True 13877642.9480579 7931340.863125375 11321364.558067573 1.0 0.571519305750356 0.8157988067888673 23.726259218013038 -10.17900258914874 5.453347419336805 1.0000102098869699 0.6936590562695653 0.6770949706203115 0.09972668869450148 1.2379727833490567e-05 1.8639472539883037e-06 0.09656316829830257 0.03218665037382758 6.622125557540302e-11 10.17900258914874 -0.3063511536174046 (ac)SSGIHVALVTGGNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSGIHVALVTGGNK 14 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 120502000.0 33424000.0 52763000.0 34315000.0 False True 43268026.88553933 49826692.66759534 28070022.101633303 1.0 1.151582271116874 0.6487474498407189 25.366797996495443 -6.825868121896323 1.3462971039685214 1.0812542693651093 0.636325788403055 0.8973499873426545 0.06747651457594485 0.18596578867655536 0.6606516735132333 0.03936831048430463 0.09062742530465408 1.4932477811908877e-07 6.825868121896323 -0.4449284809620543 (ac)SSGNAK(ub)IGHPAPNFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSGNAKIGHPAPNFK 15 1 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 1 9116100.0 3082700.0 3484900.0 2548500.0 True False 4041449.552909261 2964966.504033806 2284805.666938201 1.0 0.7336393700372821 0.5653431119271228 21.946441408764272 -9.215011782636813 0.0919091824353116 1.685205774379426 3.4046529217177966e-07 0.9999696921462496 0.000985132235620401 0.6695231976144611 0.032349659437668106 0.3461114353927255 0.23341874713494534 6.095203604091495e-10 9.215011782636813 -1.6852054339141338 (ac)SSGNAK(ub)IGHPAPNFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSGNAKIGHPAPNFK 15 1 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 1 14514000.0 3621600.0 5837300.0 5055100.0 True False 3506634.2903636177 8168164.3311173655 3731017.6602506777 1.0 2.3293459353785004 1.063988243799382 21.74165554796447 -6.6347169231642695 2.0649372934991725 1.8728250142927207 1.0693133109909563 0.13428226921827946 0.5695547638935845 0.5467177045461589 4.449147650399784 0.2252072198330479 0.6302166487687212 2.3189056398886493e-07 6.6347169231642695 -0.8035117033017645 (ac)SSGNAK(ub)IGHPAPNFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSGNAKIGHPAPNFK 15 1 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 1 29463600.0 10189000.0 9942600.0 9332000.0 True False 15457457.91567749 8168265.348111642 7487526.109639094 1.0 0.5284352312437548 0.48439569756453843 23.881799741947916 -13.999999999999998 0.33541878006547327 6.304243855602649 0.47708255272246486 0.9997259758164992 0.003863153009441624 19.291181582176115 0.18550075039909228 72.3860445536881 0.013833210694686066 1.0000000000000041e-14 13.999999999999998 -5.827161302880184 (ac)SSGNAK(ub)IGHPAPNFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSGNAKIGHPAPNFK 15 1 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 1 8266600.0 3082700.0 2745900.0 2438000.0 True False 4222457.496835092 2624577.058522983 1862194.6121861099 1.0 0.6215757199427615 0.4410215173466879 22.009651470287164 -13.99999999999997 0.09811857095569773 2.879638703707961 0.044992545252266786 0.9998031053128712 0.0032682961020182337 12.095013862943365 0.09289860669165506 4.626075922325038 0.353606613119145 1.0000000000000696e-14 13.99999999999997 -2.8346461584556946 (ac)SSGNAK(ub)IGHPAPNFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSGNAKIGHPAPNFK 15 1 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 1 13144300.0 3621600.0 6557400.0 2965300.0 True False 3011520.8640833185 6522073.984658004 3585330.520001899 1.0 2.165707720123423 1.1905381638766244 21.522060823398746 -6.602263173475128 2.181636643612331 1.782773893641173 1.1937233545219366 0.02728964158403746 0.5035551125458422 0.6342506966297687 5.708164049416136 0.19133547678709664 0.5600701793384937 2.498830663096996e-07 6.602263173475128 -0.5890505391192364 (ac)SSGNAK(ub)IGHPAPNFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSGNAKIGHPAPNFK 15 1 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 1 27820800.0 10189000.0 7692000.0 9939800.0 True False 13189861.355216611 7263933.438188578 8130858.390960648 1.0 0.550720985047783 0.6164476010769347 23.652926064040365 -10.544038340402226 6.3092509957561775 1.000553032364288 0.5835842930624089 0.9816578695847078 0.026832778631875942 0.00020899893198360114 1.5104087623876638e-05 0.026013544932153864 0.00866024206447714 2.8573382805915226e-11 10.544038340402226 -0.41696873930187905 (ac)SSILPFTPPVVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSILPFTPPVVKR 13 1 Q15796-2;Q15796;B7Z5N5;K7ESI8;K7EL92;K7ERC7;K7EJX0 Q15796-2 SMAD2 Mothers against decapentaplegic homolog 2;Mothers against decapentaplegic homolog 1 4198260.0 1558200.0 1852500.0 787560.0 True False 1508735.7939155586 2592212.910659881 581274.4097064397 1.0 1.7181357538634512 0.3852724990356878 20.524908756116194 -6.760349779438203 1.6110386841531041 1.4169462912978599 0.38029793038690335 0.6924522416808483 0.30206576105198973 0.2823230535588048 1.4442481037105082 0.14792808174790967 0.3553881004742436 1.7364017727872164e-07 6.760349779438203 -1.0366483609109565 (ac)SSNECFK(ub)CGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSNECFKCGR 10 1 P62633-2;P62633;P62633-7;P62633-3;P62633-8;P62633-5;P62633-4;P62633-6;D6RAT4 P62633-2 CNBP Cellular nucleic acid-binding protein 1 4465320.0 2237900.0 1550200.0 677220.0 True False 2933908.5718544293 1318916.2026322724 607147.7707529487 1.0 0.4495423665498301 0.20694161248835036 21.484392482943722 -10.008265809813762 0.2025774315857072 1.6289519777745791 2.577304791036077e-14 0.9994050755243453 0.008092871155113954 1.5202359980359155 0.09272369444736929 0.6668241839972497 0.14096819271417338 9.81147248317774e-11 10.008265809813762 -1.6289519777745534 (ac)SSNECFK(ub)CGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSNECFKCGR 10 1 P62633-2;P62633;P62633-7;P62633-3;P62633-8;P62633-5;P62633-4;P62633-6;D6RAT4 P62633-2 CNBP Cellular nucleic acid-binding protein 1 10223700.0 3296800.0 3246800.0 3680100.0 True False 5001486.628364469 2667383.1726358132 2952726.6219548685 1.0 0.5333180653745088 0.5903697922952234 22.253925550729022 -10.124202409659727 5.179124770135295 1.0000127574489754 0.5618439288350857 0.9874439320414669 0.0232912699851755 3.4310281982499106e-06 5.802330900056423e-07 0.022552331299447295 0.007517225063460704 7.512726701644373e-11 10.124202409659727 -0.4381688286138897 (ac)SSNECFK(ub)CGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSNECFKCGR 10 1 P62633-2;P62633;P62633-7;P62633-3;P62633-8;P62633-5;P62633-4;P62633-6;D6RAT4 P62633-2 CNBP Cellular nucleic acid-binding protein 1 4397580.0 2237900.0 1292300.0 867380.0 True False 3065312.1069735186 1235201.9129353769 662522.7082518412 1.0 0.40296122216244123 0.21613548152066356 21.547602544466613 -13.999999999999464 0.16264928829835787 3.957394030287694 0.03774132423455504 0.9995296519663033 0.007250111436455768 12.028383199853753 0.12753258125444067 11.220667976918751 0.16314804553454007 1.0000000000012352e-14 13.999999999999464 -3.9196527060531388 (ac)SSNECFK(ub)CGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSNECFKCGR 10 1 P62633-2;P62633;P62633-7;P62633-3;P62633-8;P62633-5;P62633-4;P62633-6;D6RAT4 P62633-2 CNBP Cellular nucleic acid-binding protein 1 8226000.0 3296800.0 2652600.0 2276600.0 True False 4267772.589643551 2504980.4781771996 1862282.1598886321 1.0 0.5869526610335202 0.4363592765949537 22.02505187282147 -13.999999999957282 0.14032237656685742 2.973625189264301 0.25071391292287076 0.9996016512772727 0.004755661766711571 11.93430900893194 0.11738763955670302 6.448264256130119 0.16600033466605119 1.0000000000983615e-14 13.999999999957282 -2.72291127634143 (ac)SSSPVNVK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSSPVNVKK 9 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 7241100.0 2239800.0 3150500.0 1850800.0 True False 2168698.7750045364 4408511.0796404565 1366019.9571901576 1.0 2.0327908746253778 0.6298799874534444 21.048398250740856 -6.709464825523502 1.7974265772018798 1.6352878836928657 0.6332696591867965 0.4624609554400986 0.43524819310292345 0.3761289973444965 2.3685157771870182 0.19273973025795008 0.48990997671983977 1.952248844618501e-07 6.709464825523502 -1.0020182245060694 (ac)SSSPVNVK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSSPVNVKK 9 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 4247030.0 2083100.0 1270800.0 893130.0 True False 2853278.3636608133 1214651.854026368 682191.0885897388 1.0 0.42570394445074233 0.23909026798018893 21.444189071337668 -13.999999999999998 0.15719857315648253 3.812230250450829 0.049848812330178176 0.9995440191768337 0.006914351095542231 11.99216871442136 0.12519368871608483 10.285750266630759 0.1718904566309204 1.0000000000000041e-14 13.999999999999998 -3.762381438120651 (ac)SSSPVNVK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSSPVNVKK 9 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 7376760.0 2239800.0 4183900.0 953060.0 True False 1862492.9399640535 4161360.500260871 1152340.4395484477 1.0 2.2342959862930734 0.6187086215589565 20.828803526175133 -6.702530154484842 1.8219374413411946 1.764539895780043 0.6232925100985757 0.4295738878883212 0.5207738794297332 0.39027106490149777 2.5203526075244125 0.22788824241005215 0.5842251954065052 1.9836719192322025e-07 6.702530154484842 -1.1412473856814676 (ac)SSVAVLTQESFAEHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSVAVLTQESFAEHR 15 0 A0A024R4E5;Q00341;C9JIZ1;C9J5E5;C9JZI8;C9JES8;C9JHS7;C9JHZ8;C9JK79;C9JT62;C9JHN6;C9JEJ8;C9JBS3;C9JQ82;C9JMQ6;C9J739;C9JHS9 A0A024R4E5 HDLBP Vigilin 0 2528830.0 582530.0 1946300.0 0.0 False True 763702.471228544 1655919.6266179807 0.0 1.0 2.1682784710047556 0.0 19.54265116651183 -6.764271841753598 1.6218618422471685 1.6781262313802838 3.561911948858354e-08 0.6922595524911094 0.4915495007781745 0.27939875222745403 1.4536224339170565 0.24005794104402853 0.568687176529084 1.720791127932079e-07 6.764271841753598 -1.6781261957611644 (ac)SSVAVLTQESFAEHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSVAVLTQESFAEHR 15 0 A0A024R4E5;Q00341;C9JIZ1;C9J5E5;C9JZI8;C9JES8;C9JHS7;C9JHZ8;C9JK79;C9JT62;C9JHN6;C9JEJ8;C9JBS3;C9JQ82;C9JMQ6;C9J739;C9JHS9 A0A024R4E5 HDLBP Vigilin 0 3672230.0 582530.0 1876500.0 1213200.0 False True 797907.083281327 1793590.0252443203 926667.1466383066 1.0 2.247868282943835 1.1613722525528467 19.605861228034723 -6.612630698307753 2.1436646300117905 1.8322188402340112 1.1653144572826255 0.058697448028160126 0.5376355990651701 0.6054676526805699 5.276047410889555 0.20681750712598942 0.5967515839336872 2.4398846889469343e-07 6.612630698307753 -0.6669043829513857 (ac)STDTGVSLPSYEEDQGSK(ub)LIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STDTGVSLPSYEEDQGSKLIR 21 1 C9JAW5;C9JNU6;Q9Y241 C9JAW5 HIGD1A HIG1 domain family member 1A, mitochondrial 1 4546900.0 1245800.0 2234100.0 1067000.0 True False 1035937.8982977122 2222064.4598658723 1290104.7667494104 1.0 2.144978442739901 1.2453495222728637 19.982506089237326 -10.082396047766691 4.162779078608604 0.999900665169988 1.6951639812904165 0.44324881986805265 0.3672719694573615 257224916.61619195 527012317.70927846 376359.0558980735 0.1344078182108012 8.271874795283571e-11 10.082396047766691 0.6952633161204285 (ac)STDTGVSLPSYEEDQGSK(ub)LIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STDTGVSLPSYEEDQGSKLIR 21 1 C9JAW5;C9JNU6;Q9Y241 C9JAW5 HIGD1A HIG1 domain family member 1A, mitochondrial 1 26553900.0 3608200.0 5386700.0 17559000.0 True False 4670886.028255227 5086925.4097101465 14363442.170554526 1.0 1.089070762792799 3.0751001166945358 22.155264812476194 -6.916285713336 0.8518110841326014 0.9500440875706317 3.3695248419355304 0.9930855956301649 0.07965281140071304 0.10040696874458192 0.11730032155753589 0.0673118521214921 0.19499810785033833 1.2125908496187047e-07 6.916285713336 2.4194807543648986 up (ac)STGTFVVSQPLNYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STGTFVVSQPLNYR 14 0 P49189 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 8979400.0 2735400.0 2767200.0 3476800.0 False True 3586135.8896512855 2354344.546461117 3117054.087820574 1.0 0.6565129205658887 0.8691957537960658 21.77399872669152 -10.390408884962454 5.785150542865919 1.0000705405458759 0.7628543371809768 0.6237338871679912 0.08682740307723213 7.902074326409465e-05 8.326546912633506e-06 0.08409520481560799 0.028023423842713002 4.069969128567032e-11 10.390408884962454 -0.23721620336489901 (ac)STGTFVVSQPLNYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STGTFVVSQPLNYR 14 0 P49189 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 9642000.0 2735400.0 2801800.0 4104800.0 False True 3746751.3014055006 2678007.2116864 3135330.7810096582 1.0 0.7147544622675682 0.8368131559288488 21.83720878821441 -10.123549691972702 4.619103561165571 1.0000200563578594 0.7757838090940486 0.8181553464222653 0.049830253037684714 1.0293037403655193e-05 1.953020454158636e-06 0.04825224857713977 0.016082645010681646 7.524026353419791e-11 10.123549691972702 -0.22423624726381075 (ac)STLYVSPHPDAFPSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STLYVSPHPDAFPSLR 16 0 P26640;A0A140T954;A2ABF4;A0A0G2JJT9 P26640 VARS Valine--tRNA ligase 0 45695000.0 11254000.0 16880000.0 17561000.0 False True 14754102.98389104 14361569.797724668 15743956.177006777 1.0 0.9733949812743647 1.0670900287327862 23.814612875050518 -6.830859294397472 1.3242719211827216 0.9857928416264804 1.0696521247733413 0.907542953735207 0.011987296693869765 0.17975549372026992 0.616249513443145 0.007107009824588788 0.016353155778508915 1.4761847199108287e-07 6.830859294397472 0.08385928314686086 (ac)STLYVSPHPDAFPSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STLYVSPHPDAFPSLR 16 0 P26640;A0A140T954;A2ABF4;A0A0G2JJT9 P26640 VARS Valine--tRNA ligase 0 43036000.0 11254000.0 15613000.0 16169000.0 False True 15414907.92791456 14923166.03471332 12350215.211007891 1.0 0.9680995893390479 0.8011864403447473 23.87782293657341 -6.938797325218948 0.6706588388425743 1.001918192164665 0.7577243217936641 0.9980020863889814 0.003896806617016017 0.08831963583310236 0.05714052911606078 0.003759534694768717 0.014443670743396432 1.1513375651195496e-07 6.938797325218948 -0.24419387037100082 (ac)STNICSFK(ub)DR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STNICSFKDR 10 1 U3KQ03;A0A087WZP4;A0A087WSW5;Q86X60;Q6L9T8;Q5TYM5;H0Y354 U3KQ03 FAM72A;FAM72B;FAM72C;FAM72D Protein FAM72B;Protein FAM72D;Protein FAM72A;Protein FAM72C 1 12060000.0 2483900.0 4391900.0 5184200.0 True False 3256416.9541218188 3736645.639492118 4647788.71435787 1.0 1.1474714977031575 1.4272707641062115 21.634854004533835 -6.961062651681648 0.4201915332715639 0.9876578393944639 1.5976424314300361 0.9998075968073771 0.0024579130705574773 0.07932371733125128 0.01974491667400045 0.003619883968537519 0.023289912626079986 1.0937985626033827e-07 6.961062651681648 0.6099845920355722 (ac)STNICSFK(ub)DR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STNICSFKDR 10 1 U3KQ03;A0A087WZP4;A0A087WSW5;Q86X60;Q6L9T8;Q5TYM5;H0Y354 U3KQ03 FAM72A;FAM72B;FAM72C;FAM72D Protein FAM72B;Protein FAM72D;Protein FAM72A;Protein FAM72C 1 9847600.0 3550800.0 2893000.0 3403800.0 True False 3438081.79760965 4048189.986795699 2512242.668188811 1.0 1.1774559842090526 0.7307105578277587 21.713172438631705 -6.7989244227882395 1.4602643930718684 1.0980457492132272 0.7247041410743068 0.8289981366081416 0.07594900948854909 0.22230386308424838 0.9359636150107679 0.04091813192217335 0.0952250307189244 1.5888232162620895e-07 6.7989244227882395 -0.37334160813892037 (ac)STNICSFK(ub)DR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STNICSFKDR 10 1 U3KQ03;A0A087WZP4;A0A087WSW5;Q86X60;Q6L9T8;Q5TYM5;H0Y354 U3KQ03 FAM72A;FAM72B;FAM72C;FAM72D Protein FAM72B;Protein FAM72D;Protein FAM72A;Protein FAM72C 1 41866700.0 4207700.0 12157000.0 25502000.0 True False 6383388.52407461 9987488.366925474 20461518.522076312 1.0 1.5646060598157534 3.205432106303225 22.605891029227745 -6.952163666662944 0.5345704978876057 0.9749416712917419 3.8701674783442037 0.9993602781039993 0.023659207737715942 0.08262853305859084 0.03245645765801921 0.026220943856679623 0.13577186242706726 1.1164424299961767e-07 6.952163666662944 2.8952258070524617 (ac)STNICSFK(ub)DR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STNICSFKDR 10 1 U3KQ03;A0A087WZP4;A0A087WSW5;Q86X60;Q6L9T8;Q5TYM5;H0Y354 U3KQ03 FAM72A;FAM72B;FAM72C;FAM72D Protein FAM72B;Protein FAM72D;Protein FAM72A;Protein FAM72C 1 12380100.0 2483900.0 4396400.0 5499800.0 True False 3402264.954873553 4202152.511049361 4200860.511936493 1.0 1.2351044280164054 1.2347246812506465 21.698064066056727 -10.107049935156656 5.028897937782892 0.9999924080496992 1.2349145546342262 0.999998037405205 0.00015503097036083963 1.3196645022584028e-08 2.3432855532510724e-09 0.00015011293886246026 5.003603018141251e-05 7.81537938231038e-11 10.107049935156656 0.23492214658452693 (ac)STNICSFK(ub)DR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STNICSFKDR 10 1 U3KQ03;A0A087WZP4;A0A087WSW5;Q86X60;Q6L9T8;Q5TYM5;H0Y354 U3KQ03 FAM72A;FAM72B;FAM72C;FAM72D Protein FAM72B;Protein FAM72D;Protein FAM72A;Protein FAM72C 1 13555500.0 3550800.0 2286900.0 7717800.0 True False 2952647.527111505 2274580.015785891 9331556.29692466 1.0 0.7703527071553478 3.1604030658049687 21.49357771406598 -6.883331202322803 1.061092713697656 0.8503081120568398 3.3409551400386106 0.9762727442926538 0.16584219298221878 0.12471815824138735 0.2548265633333706 0.1200169010872532 0.2928390199866565 1.308183893284448e-07 6.883331202322803 2.4906470279817707 up (ac)STNICSFK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STNICSFKDR 10 1 U3KQ03;A0A087WZP4;A0A087WSW5;Q86X60;Q6L9T8;Q5TYM5;H0Y354 U3KQ03 FAM72A;FAM72B;FAM72C;FAM72D Protein FAM72B;Protein FAM72D;Protein FAM72A;Protein FAM72C 1 28371600.0 4207700.0 9990900.0 14173000.0 True False 5446950.59616694 9434897.632293068 11593659.427260637 1.0 1.7321430524691146 2.128467887228348 22.377017351320195 -9.543803637299984 0.15813685639288574 4.779649671906203e-12 2.7036074554915612 0.9997366162026409 0.007586217109782265 1.0008083251174276 0.06406705546093243 0.7589153235275812 0.3093777462288557 2.8588828717166695e-10 9.543803637299984 2.7036074554867815 (ac)STVHEILCK(ub)LSLEGDHSTPPSAYGSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STVHEILCKLSLEGDHSTPPSAYGSVK 27 1 P07355;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 58516000.0 21640000.0 19549000.0 17327000.0 True False 32829462.09591331 16060328.212965844 13902310.85530611 1.0 0.4892047322019654 0.423470564783841 24.96848777605006 -13.999999999999998 0.28906090525211076 5.378303893848037 0.4053876931120247 0.9996253608607523 0.0049876643263908026 15.91017408885967 0.17047766142362983 41.40085623027285 0.024931946317154768 1.0000000000000041e-14 13.999999999999998 -4.972916200736012 (ac)STVHEILCK(ub)LSLEGDHSTPPSAYGSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STVHEILCKLSLEGDHSTPPSAYGSVK 27 1 P07355;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 1 55238000.0 21640000.0 21591000.0 12007000.0 True False 28013406.588172276 20389441.869985662 9821849.202223834 1.0 0.7278458550126646 0.35061245305206046 24.73961409814251 -6.966536504351658 0.3306253921453549 1.045625199790662 0.020472370235629447 0.9999414007985248 0.0020382593012000507 0.07744339764036964 0.013042300292833875 0.0054922339297563 0.032886593835591525 1.08009883003313e-07 6.966536504351658 -1.0251528295550325 down (ac)SVTLHTDVGDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVTLHTDVGDIK 12 0 B8ZZ77;Q9H2H8;Q9H2H8-2;F8WC82;C9K058;C9J4N2 B8ZZ77;C9J4N2 PPIL3 Peptidyl-prolyl cis-trans isomerase-like 3;Peptidyl-prolyl cis-trans isomerase 0 7363600.0 1480200.0 2855500.0 3027900.0 False True 1940556.5342771905 2429470.530651821 2714601.953667721 1.0 1.2519452475301054 1.398878056742028 20.888039033126876 -11.485903824754006 0.07844447312320144 2.6823395447602133e-17 1.9163774653263128 0.9999427484145492 0.0012462736960351258 4.473856124805 0.0539649422084036 1.138280378275588 0.3587632675148531 3.2666016360762965e-12 11.485903824754006 1.9163774653263128 (ac)SVTLHTDVGDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVTLHTDVGDIK 12 0 B8ZZ77;Q9H2H8;Q9H2H8-2;F8WC82;C9K058;C9J4N2 B8ZZ77;C9J4N2 PPIL3 Peptidyl-prolyl cis-trans isomerase-like 3;Peptidyl-prolyl cis-trans isomerase 0 6944000.0 2333500.0 1241600.0 3368900.0 False True 2259424.319793322 1737377.3548584664 2486484.025166369 1.0 0.768946912555757 1.1004944947188215 21.107523803568135 -6.719327239598555 1.7618811557638854 0.8593286135929458 1.0999532822494595 0.5092882821473419 0.09723600670275313 0.3566195648077793 2.163160796902093 0.04382827256338968 0.11010648497719282 1.9084147318553206e-07 6.719327239598555 0.24062466865651377 (ac)SVTLHTDVGDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVTLHTDVGDIK 12 0 B8ZZ77;Q9H2H8;Q9H2H8-2;F8WC82;C9K058;C9J4N2 B8ZZ77;C9J4N2 PPIL3 Peptidyl-prolyl cis-trans isomerase-like 3;Peptidyl-prolyl cis-trans isomerase 0 6188200.0 1480200.0 2306900.0 2401100.0 False True 2027469.9409009342 2204973.530101848 1834009.6322067543 1.0 1.0875493074496767 0.9045804306187577 20.951249094649768 -6.776632667190881 1.549394337532058 1.0497905430441783 0.9032915127493301 0.755145226257242 0.03697343181735086 0.2558482797126917 1.2129613105129382 0.018801336986311926 0.04448231882480474 1.6725046458232147e-07 6.776632667190881 -0.14649903029484823 (ac)SYAEKPDEITK(ub)DEWMEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYAEKPDEITKDEWMEK 17 2 Q9NWU2 Q9NWU2 GID8 Glucose-induced degradation protein 8 homolog 1 10766100.0 2299000.0 3754800.0 4712300.0 True False 2226019.503408976 5254111.221023329 3478007.264030245 1.0 2.3603167955074364 1.562433419250796 21.08603480232217 -10.290534628221392 5.470564931950663 0.999873608901167 1.9613751073791492 0.6593696687880553 0.3257345243464243 0.00050219267369318 6.512804755778542e-05 0.315431745791021 0.10513036567319127 5.1223042623701514e-11 10.290534628221392 0.9615014984779822 (ac)SYAEKPDEITK(ub)DEWMEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYAEKPDEITKDEWMEK 17 2 Q9NWU2 Q9NWU2 GID8 Glucose-induced degradation protein 8 homolog 1 8072500.0 2299000.0 3857800.0 1915700.0 True False 1911720.3629687268 3837017.265686656 2316264.012803977 1.0 2.0071017393611474 1.2116123559028429 20.866440077756447 -10.224128900652431 4.74433239445854 0.9998729873871809 1.6093570476338974 0.4389500854410934 0.32475718088598565 0.0004364218791830789 7.137124590864117e-05 0.3145097136092664 0.1048149294267342 5.968581099870411e-11 10.224128900652431 0.6094840602467165 (ac)SYAEKPDEITK(ub)DEWMEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYAEKPDEITKDEWMEK 17 2 Q9NWU2 Q9NWU2 GID8 Glucose-induced degradation protein 8 homolog 1 25662300.0 4215000.0 8323300.0 13124000.0 True False 5456400.590071455 7860101.038231278 10735566.663611704 1.0 1.440528588119727 1.9675180526785911 22.37951813525778 -6.968744434773868 0.28659661657495167 0.8927469722217775 2.531504514293263 0.9999708634355324 0.0021349037599003484 0.07671227694568193 0.010481496741397462 0.00937887464242878 0.047981135508540926 1.074621598871337e-07 6.968744434773868 1.6387575420714855 (ac)SYGRPPPDVEGMTSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYGRPPPDVEGMTSLK 16 1 J3QL05;J3KP15;Q01130-2;Q01130 J3QL05 SRSF2 Serine/arginine-rich splicing factor 2 0 21856600.0 6683400.0 2194200.0 12979000.0 False True 6471239.125308207 3070355.502601837 9579410.538346149 1.0 0.47446175966424425 1.4803054489027105 22.625610558013683 -6.7647239463574715 1.5946322965855249 0.6965367897989461 1.4848706445800768 0.7099694212736704 0.2212193411055015 0.2750540765822158 1.3794448039991336 0.10940369026306446 0.26170875886348965 1.7190007004153586e-07 6.7647239463574715 0.7883338547811307 (ac)TDSK(ub)YFTTNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDSKYFTTNK 10 1 P63010;P63010-2;A0A087X253;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;A0A087WXS3;K7EKZ5 P63010 AP2B1 AP-2 complex subunit beta 1 6951000.0 2856000.0 2614800.0 1480200.0 True False 3744243.657543345 2224682.0324105714 1327043.1030809996 1.0 0.5941605931357092 0.3544222076486584 21.83624289102206 -8.993825674140037 0.16359322568359652 1.4691686292632773 9.714051812687326e-12 0.999791043079547 0.003851592633176973 0.4648548464337348 0.05280615393033256 0.269585804481762 0.1605234580208465 1.0143184515878234e-09 8.993825674140037 -1.4691686292535633 (ac)TDSK(ub)YFTTNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDSKYFTTNK 10 1 P63010;P63010-2;A0A087X253;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;A0A087WXS3;K7EKZ5 P63010 AP2B1 AP-2 complex subunit beta 1 7726100.0 2006100.0 2637100.0 3082900.0 True False 1942417.4535836212 3690107.7822948224 2275396.0049824566 1.0 1.899750115757474 1.1714248143644477 20.889421859418693 -10.26828364210783 4.798532944566539 0.9998349310629203 1.53558746506179 0.4189500342515383 0.2973375591981348 0.0005252398385424896 8.009199075299056e-05 0.2879836063344203 0.0959652845809559 5.391583777241477e-11 10.26828364210783 0.5357525339988697 (ac)TDSK(ub)YFTTNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDSKYFTTNK 10 1 P63010;P63010-2;A0A087X253;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;A0A087WXS3;K7EKZ5 P63010 AP2B1 AP-2 complex subunit beta 1 16847100.0 7932300.0 4603900.0 4310900.0 True False 12033879.028808359 3782298.0745651196 3458848.7254654104 1.0 0.31430414627823106 0.28742591787611804 23.520598423398283 -13.349265160429345 0.4689893295534956 9.99999999996652 0.28800187069120947 0.9999077356467092 0.0031674633182915855 21.021328271993905 0.2358962875243745 192.92323894589174 0.005823220385938873 4.474400342569116e-14 13.349265160429345 -9.71199812927531 (ac)TDSK(ub)YFTTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDSKYFTTNK 10 1 P63010;P63010-2;A0A087X253;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;A0A087WXS3;K7EKZ5 P63010 AP2B1 AP-2 complex subunit beta 1 6072200.0 2856000.0 1715000.0 1501200.0 True False 3911940.3804979543 1639225.6292534035 1146647.4781844926 1.0 0.4190313424574086 0.2931147631750295 21.89945295254495 -13.999999999999998 0.21488947603109906 4.429320968787787 0.22237247571902832 0.999493313632011 0.006930101549623414 12.86558521833587 0.14689294561579141 18.673008902477 0.07211139088739235 1.0000000000000041e-14 13.999999999999998 -4.206948493068758 (ac)TDSK(ub)YFTTNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDSKYFTTNK 10 1 P63010;P63010-2;A0A087X253;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;A0A087WXS3;K7EKZ5 P63010 AP2B1 AP-2 complex subunit beta 1 7665500.0 2006100.0 3875600.0 1783800.0 True False 1668161.035298635 3854721.373553635 2156784.332640676 1.0 2.3107609469271417 1.2929113478870864 20.66982713485297 -10.190492060414206 4.683392262455511 0.9998703291345494 1.801836147412378 0.4527899866408983 0.41553535877546727 0.0005627070755385062 9.726205275738725e-05 0.40240463721780867 0.1341134603555902 6.449231099685355e-11 10.190492060414206 0.8019658182778286 (ac)TDSK(ub)YFTTTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDSKYFTTTK 10 1 Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 Q10567-3 AP1B1 AP-1 complex subunit beta-1 1 4910400.0 1689600.0 2086300.0 1134500.0 True False 2215081.9621096742 1775032.172333707 1017112.8228924422 1.0 0.801339274436212 0.4591761570410379 21.07892865146405 -6.962859091198078 0.3930717238508226 1.020308416503097 0.22785208859905773 0.9998619791097639 0.002624150907551463 0.07869521732200968 0.017470247842710236 0.004411012066740911 0.028745333129081885 1.0892834589322106e-07 6.962859091198078 -0.7924563279040392 down (ac)TDSK(ub)YFTTTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDSKYFTTTK 10 1 Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 Q10567-3 AP1B1 AP-1 complex subunit beta-1 1 7767100.0 3070200.0 1944600.0 2752300.0 True False 2972738.181542513 2721088.9209550363 2031390.0627698652 1.0 0.9153476541762251 0.6833397153447953 21.503360975447826 -6.953463230032109 0.5194337301156305 1.0039597424994342 0.5843839158891163 0.999445786026967 0.0031513025238765874 0.08212417235325872 0.0304323168476753 0.003573249263800981 0.01916292122203672 1.1131066310760399e-07 6.953463230032109 -0.4195758266103179 (ac)TDSK(ub)YFTTTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDSKYFTTTK 10 1 Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 Q10567-3 AP1B1 AP-1 complex subunit beta-1 1 3785520.0 1689600.0 1127500.0 968420.0 True False 2314290.779723157 1077683.3218560982 739699.141235962 1.0 0.4656646136683888 0.31962238613958754 21.14213871298694 -13.999999999999998 0.18202021050909578 3.7898607246227267 0.20600127205201002 0.9994958407564284 0.006566577593417548 12.23154376953654 0.1352637921090929 12.074433668354942 0.10719674731306952 1.0000000000000041e-14 13.999999999999998 -3.583859452570717 (ac)TDSK(ub)YFTTTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDSKYFTTTK 10 1 Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 Q10567-3 AP1B1 AP-1 complex subunit beta-1 1 8291300.0 3070200.0 3435700.0 1785400.0 True False 2553007.3329215245 3417191.2021669415 2158718.885243109 1.0 1.3384964305043696 0.8455592184973425 21.283766250882103 -6.721903766196613 1.7525455583018215 1.2055167222238952 0.8462478996249623 0.5214699847125676 0.14240801474222514 0.3516217018407686 2.1116476809508637 0.06449567904746555 0.16154194610007558 1.897126252245943e-07 6.721903766196613 -0.3592688225989329 (ac)TEADVNPK(ub)AYPLADAHLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEADVNPKAYPLADAHLTK 19 1 P55769 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 33748700.0 11492000.0 15483000.0 6773700.0 True False 15066123.288686294 13172996.752261316 6072822.501918503 1.0 0.8743454769252688 0.4030779773638789 23.844804904525482 -6.946356576794081 0.5975161731325889 1.0053384719825038 0.24806372825296213 0.9988833697272808 0.008586159362985728 0.08498281301973151 0.042279128827119934 0.008834050611256248 0.0395723100226975 1.1314709892999129e-07 6.946356576794081 -0.7572747437295417 down (ac)TEADVNPK(ub)AYPLADAHLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEADVNPKAYPLADAHLTK 19 1 P55769 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 50846000.0 17916000.0 19203000.0 13727000.0 True False 17347266.386722583 26870858.04232208 10131486.898827149 1.0 1.5489966801275823 0.5840393911620383 24.04820500245969 -6.75237183871829 1.6410464266966986 1.3218896920123233 0.5817656612402174 0.6591384887626215 0.2307240728366462 0.29591786330488884 1.5686279549305961 0.11103121307138024 0.2688881125293871 1.7685940568300575e-07 6.75237183871829 -0.7401240307721059 (ac)TEADVNPK(ub)AYPLADAHLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEADVNPKAYPLADAHLTK 19 1 P55769 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 117370000.0 29458000.0 35202000.0 52710000.0 True False 44689939.66827243 28919928.065518636 42291845.39638626 1.0 0.6471239003719288 0.9463392815097333 25.413446761297493 -10.080145160502347 7.0177735440377935 1.000000071242136 0.796731590940831 0.3809328586128162 0.12215416783000213 1.362024827485863e-07 1.7830903436751795e-08 0.11827530671723989 0.03942508813961863 8.314858051696078e-11 10.080145160502347 -0.20326848030130495 (ac)TEADVNPK(ub)AYPLADAHLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEADVNPKAYPLADAHLTK 19 1 P55769 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 30060100.0 11492000.0 12019000.0 6549100.0 True False 15740902.959622696 11487960.838482002 5002337.462948349 1.0 0.7298158732030812 0.31779228140723215 23.908014966048373 -6.970791257169987 0.35946523313781986 1.035861924688604 6.179087431089891e-10 0.9999132031770526 0.002613355227467577 0.07714617699966798 0.014872544140417322 0.005517004790836806 0.03484942405241431 1.0695688419575073e-07 6.970791257169987 -1.0358619240706952 down (ac)TEADVNPK(ub)AYPLADAHLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEADVNPKAYPLADAHLTK 19 1 P55769 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 43893500.0 17916000.0 21457000.0 4520500.0 True False 14897947.813374385 21341406.88211896 5465715.64956955 1.0 1.4325064867632349 0.36687708388015655 23.828610277893965 -6.79655119809327 1.470203704970601 1.239690378180382 0.3534323342063912 0.8217983251694705 0.18472973891884525 0.22572969056510908 0.9636209834205187 0.09886980068400342 0.23040905142759852 1.5975291884900948e-07 6.79655119809327 -0.8862580439739909 down (ac)TEADVNPK(ub)AYPLADAHLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEADVNPKAYPLADAHLTK 19 1 P55769 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 113097000.0 29458000.0 34401000.0 49238000.0 True False 38133961.703991674 32486554.109090615 40277189.22454377 1.0 0.8519060873156036 1.0562025927751366 25.184573083389942 -6.712208990176847 1.7868451324733334 0.909166535148817 1.055765707263178 0.47587231943093 0.06238428856018935 0.37062023111919734 2.307915865369209 0.027766558780153903 0.07036461890304517 1.9399521137110566e-07 6.712208990176847 0.14659917211436113 (ac)TEWETAAPAVAETPDIK(ub)LFGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEWETAAPAVAETPDIKLFGK 21 1 M0R0F0;P46782;M0R0R2;M0QZN2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 1 11315500.0 3366700.0 2862600.0 5086200.0 True False 3259825.9513384067 4005651.1082617906 3753971.6372706816 1.0 1.2287929380454088 1.1515865243447707 21.636363507447957 -10.07338049236913 4.20729408923554 0.9999764787396629 1.1901897312347771 0.8900019760451263 0.03151938655430157 4496762.541429205 5383222.712054658 770.5939646311108 0.01078992372768042 8.44538607105841e-11 10.07338049236913 0.19021325249511423 (ac)TEWETAAPAVAETPDIK(ub)LFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEWETAAPAVAETPDIKLFGK 21 1 M0R0F0;P46782;M0R0R2;M0QZN2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 1 10248100.0 3366700.0 2400900.0 4480500.0 True False 2799560.220098656 2387965.8751586624 5417351.834508649 1.0 0.8529789279097953 1.935072443027406 21.416768782882233 -6.872597372857746 1.1202052080982736 0.9153809994176692 2.001670329427556 0.967210310688064 0.0867775416397048 0.1343918184273701 0.3136048430173598 0.060017502634853344 0.14277706141317914 1.3409192551438829e-07 6.872597372857746 1.086289330009887 (ac)TEWETAAPAVAETPDIK(ub)LFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEWETAAPAVAETPDIKLFGK 21 1 M0R0F0;P46782;M0R0R2;M0QZN2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 1 122754700.0 0.0 5754700.0 117000000.0 True False 0.0 5434445.886212142 95707200.52137819 0.0 (ac)TFNSFEGSK(ub)TCVPADINKEEEFVEEFNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFNSFEGSKTCVPADINKEEEFVEEFNR 28 2 P98170;B1AKU2 P98170 XIAP E3 ubiquitin-protein ligase XIAP 1 31382200.0 2511200.0 8007000.0 20864000.0 True False 3250797.9031524113 7561403.411281324 17066966.082718257 1.0 2.3260146082747157 5.250085237894312 21.632362438123085 -6.958090934524436 0.46155185112243574 0.9160766404490549 6.778205490799785 0.9996927121044206 0.031123925039536336 0.08039024850768271 0.023705314805294312 0.03981797772973212 0.24151778648845965 1.1013086884505225e-07 6.958090934524436 5.86212885035073 (ac)TMDKSELVQK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TMDKSELVQKAK 12 2 P31946;Q4VY19;A0A0J9YWE8;Q4VY20 P31946 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 74665000.0 23214000.0 21444000.0 30007000.0 True False 35217335.17072696 17617150.657263298 24076103.297464706 1.0 0.500240877734181 0.6836435289821994 25.069782411500256 -10.056608177050103 5.030436525332048 1.0000073290721379 0.5919422033560251 0.8684281405255526 0.07487381884606008 6.154514425482015e-06 1.154099707147541e-06 0.07249756565139902 0.024165421120402042 8.777924133047055e-11 10.056608177050103 -0.40806512571611275 (ac)TMDKSELVQK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TMDKSELVQKAK 12 2 P31946;Q4VY19;A0A0J9YWE8;Q4VY20 P31946 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 78076900.0 28130100.0 22404200.0 27542600.0 True False 36414968.9771694 21157386.575125404 22530129.410941128 1.0 0.5810079527567403 0.6187051655890888 25.118028280291885 -9.983387492356268 6.078227770622398 1.0000002648581356 0.5998565591728743 0.9933874786910636 0.015389822694202446 5.5225382084042274e-08 9.242372931142955e-09 0.014901141518606574 0.00496704391628984 1.0389927273793531e-10 9.983387492356268 -0.40014370568526136 (ac)TQFLPPNLLALFAPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQFLPPNLLALFAPR 15 0 P08621-2;P08621;P08621-3 P08621-2 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 0 292633000.0 121950000.0 82474000.0 88209000.0 False True 185007065.73921588 67755870.32769686 70774452.48662184 1.0 0.3662339600759079 0.38254999723299654 27.463005129906794 -9.74105958855617 6.304051696096116 1.0000000072423212 0.37439197870873364 0.9994901236696307 0.0066609942792271275 6.70884161831219e-10 1.524491675032145e-10 0.006449480073069952 0.002149826658988427 1.8152665770949607e-10 9.74105958855617 -0.6256080285335875 (ac)TQFLPPNLLALFAPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQFLPPNLLALFAPR 15 0 P08621-2;P08621;P08621-3 P08621-2 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 0 174305000.0 121950000.0 15072000.0 37283000.0 False True 157866678.99388227 14233229.950647201 30497876.55588502 1.0 0.09015981105929755 0.1931875475575621 27.234131451999243 -10.447358935890382 6.0788475828798285 1.0003751730497732 0.1416736793084297 0.9893095270446441 0.04206089729577831 0.00021394935027036456 1.9450496028568665e-05 0.04074195735928861 0.013575096229424101 3.569776811303875e-11 10.447358935890382 -0.8587014937413435 (ac)TSEVIEDEK(ub)QFYSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSEVIEDEKQFYSK 14 1 Q9BV86;Q9BV86-2;S4R344;S4R3J7 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 1 1455500.0 1455500.0 0.0 0.0 True False 1409295.949200419 0.0 0.0 1.0 0.0 0.0 20.426543175726756 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 (ac)TSEVIEDEK(ub)QFYSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSEVIEDEKQFYSK 14 1 Q9BV86;Q9BV86-2;S4R344;S4R3J7 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 1 30138000.0 0.0 6199000.0 23939000.0 True False 0.0 5854020.200641055 19582347.63488269 0.0 (ac)TSK(ub)GPEEEHPSVTLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSKGPEEEHPSVTLFR 16 1 Q03154;A0A1B0GV31;A0A1B0GU86;Q03154-4;Q03154-2;Q03154-3;F8WC59;C9JYZ0;A0A1B0GTG3;A0A1B0GVZ3;A0A1B0GVG0;A0A1B0GU36 Q03154 ACY1 Aminoacylase-1 1 17566000.0 2834900.0 3319100.0 11412000.0 True False 3716581.353210648 2823903.2177504655 10231195.711633824 1.0 0.7598120286835579 2.7528512736026585 21.825544757211055 -6.876784696167699 1.0975292030675863 0.8566031710881029 2.8856933777135825 0.9710000983649089 0.1512791445655608 0.13051849486405073 0.28979590792626125 0.10646417856477419 0.255490775771316 1.3280526838391718e-07 6.876784696167699 2.0290902066254795 up (ac)TSK(ub)GPEEEHPSVTLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSKGPEEEHPSVTLFR 16 1 Q03154;A0A1B0GV31;A0A1B0GU86;Q03154-4;Q03154-2;Q03154-3;F8WC59;C9JYZ0;A0A1B0GTG3;A0A1B0GVZ3;A0A1B0GVG0;A0A1B0GU36 Q03154 ACY1 Aminoacylase-1 1 34105400.0 3740200.0 4607200.0 25758000.0 True False 3621469.3982819733 6446878.986230606 19011207.07656369 1.0 1.7801832011307368 5.249583797555383 21.78814375378367 -6.94244996251675 0.636362240832586 0.962097862985723 6.256700974592586 0.9984675219896965 0.07230629319693514 0.08666649395597181 0.04965164323623363 0.07176750752240864 0.2955319550552825 1.1416948380549176e-07 6.94244996251675 5.294603111606863 (ac)TSK(ub)GPEEEHPSVTLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSKGPEEEHPSVTLFR 16 1 Q03154;A0A1B0GV31;A0A1B0GU86;Q03154-4;Q03154-2;Q03154-3;F8WC59;C9JYZ0;A0A1B0GTG3;A0A1B0GVZ3;A0A1B0GVG0;A0A1B0GU36 Q03154 ACY1 Aminoacylase-1 1 24238200.0 2834900.0 6656300.0 14747000.0 True False 3883039.140291888 6362202.656559428 11264062.323998598 1.0 1.638459574239878 2.900836668659456 21.888754818733947 -6.960268220319904 0.4316367805074906 0.9507183261244058 3.6371190752806593 0.9997800188242904 0.01171448990812512 0.07960544107785446 0.020778289736215424 0.016487583651677473 0.10477715649785276 1.095801220160101e-07 6.960268220319904 2.6864007491562534 (ac)TTQQIDLQGPGPWGFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTQQIDLQGPGPWGFR 16 0 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 0 1767540.0 0.0 838760.0 928780.0 False True 0.0 713620.2774608734 832678.7550868602 0.0 (ac)VDREQLVQK(ub)AR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDREQLVQKAR 11 2 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 116769000.0 34837000.0 34014000.0 47918000.0 True False 52850275.925847106 27943935.947405 38446986.29679449 1.0 0.528737749384931 0.7274699256204166 25.65540766800137 -10.234115066369355 5.529114790545001 1.000021664864773 0.6281038375026547 0.8236093647332201 0.08113207120836752 2.1668564498873003e-05 3.001559616656577e-06 0.07856036001706918 0.026185263386100364 5.832905409077599e-11 10.234115066369355 -0.3719178273621183 (ac)VDREQLVQK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDREQLVQKAR 11 2 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 132133000.0 34837000.0 38923000.0 58373000.0 True False 45097183.23993332 36756900.833933145 47749712.95755911 1.0 0.8150597929447865 1.0588180796905513 25.42653399009382 -6.7038559569319105 1.81725263881309 0.885593622363779 1.0581439743128676 0.4357965652576029 0.07801223485600951 0.38757473095300554 2.490978306307174 0.034214443021905315 0.0875697465523436 1.9776254531935436e-07 6.7038559569319105 0.17255035194908852 (ac)VEADRPGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEADRPGK 8 1 P38159;P38159-2;H3BT71;Q96E39;H3BR27;P38159-3;H3BNC1;A0A1B0GUK8;O75526 P38159 RBMX;RBMXL1;RBMXL2 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1;RNA-binding motif protein, X-linked-like-2 0 7218220.0 2451800.0 699620.0 4066800.0 False True 2373968.951047465 978981.9144701014 3001583.0786151555 1.0 0.41238193702497483 1.264373351340913 21.178869635532816 -6.721141108002359 1.7552296005553607 0.6429350183277225 1.2631286918320983 0.5178770942699048 0.24723800071773921 0.35311087744235176 2.1266754078091483 0.11181705349903324 0.28032443457634654 1.900460694864939e-07 6.721141108002359 0.6201936735043758 AAAAAAALQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAAAAAALQAK 11 0 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 36546200.0 9078200.0 14096000.0 13372000.0 False True 11901608.113413865 11992931.745777639 11988393.713281393 1.0 1.0076732178957268 1.0072919221537564 23.504653184005516 -10.190130401714272 3.800133109553669 0.9999937419686133 1.007482570028883 0.9980535889542099 0.00015566334936009817 8.260300954468554e-09 1.7600068308282966e-09 0.0001508464430646841 5.024012809377418e-05 6.454603933242925e-11 10.190130401714272 0.0074888280602696256 AAAAAAALQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAAAAAALQAK 11 0 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 29051600.0 6974400.0 3323200.0 18754000.0 False True 6753001.48959355 4650171.090259066 13841764.79205975 1.0 0.688608035615723 2.049720381876128 22.687097445070627 -6.846541104818605 1.2517000868746926 0.8342023814437256 2.100598041640055 0.9351155892832118 0.14832212730801306 0.1613023031952601 0.48807047796482683 0.0928015419014124 0.21432267334424956 1.4238324783082752e-07 6.846541104818605 1.2663956601963295 up AAAAAAALQAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAAAAAALQAK 11 0 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 66367400.0 3811000.0 59236000.0 3320400.0 False True 5781565.621419852 48664872.98701959 2664121.484616979 1.0 8.417248228874785 0.4607958568777288 22.46302879014805 -6.661953304437489 1.9660798605498573 5.766682590838683 0.4939110903377156 0.24393092881543765 3.1566234838993963 0.4798040891334573 3.567394290293593 1.2962650602218457 3.4998151059106966 2.1779439333984544e-07 6.661953304437489 -5.272771500500967 AAAAAAALQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAAAAAALQAK 11 0 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 33605200.0 9078200.0 10209000.0 14318000.0 False True 12434655.869130438 9757932.623351593 10936383.288466262 1.0 0.7847368456392971 0.8795083196163311 23.567863245528407 -10.163463393069826 4.638242543850115 1.000020359888776 0.8321225826284329 0.8070902829957796 0.038690292255648996 8.854046351950802e-06 1.5968937283267508e-06 0.0374666500124388 0.012487238127581634 6.863357276042396e-11 10.163463393069826 -0.16789777726034316 AAAAAAALQAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAAAAAALQAK 11 0 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 13447400.0 3811000.0 5576400.0 4060000.0 False True 4933414.626040874 5266068.437950441 3321121.6591179124 1.0 1.0674287156310893 0.6731892433260072 22.2341551122405 -6.862853556767187 1.1713347170063482 1.0368952000784941 0.6530404810811444 0.9570097541612925 0.03569748524862476 0.1438853222515322 0.3735326751972038 0.023741968035459585 0.055607343490477516 1.3713441027063809e-07 6.862853556767187 -0.3838547189973497 AAAAAAALQAK(ub)SDEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAAAAAALQAKSDEK 15 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 91588600.0 24129700.0 29209200.0 38249700.0 True False 31634270.372347202 24851301.216569822 34291987.96103049 1.0 0.7855816152565147 1.0840138734796458 24.914984985452776 -6.713887153369236 1.7813536902111735 0.8687057719702759 1.0833956408934147 0.4835147390526686 0.09030206906468927 0.36732862085279283 2.2744780533011073 0.04030528072965669 0.10191442321836158 1.9324703828994035e-07 6.713887153369236 0.2146898689231388 AAAAAAALQAK(ub)SDEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAAAAAALQAKSDEK 15 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 77833500.0 34917400.0 30924100.0 11992000.0 True False 33808966.24981842 43272254.39705114 8850935.447711453 1.0 1.2799046879253086 0.26179254882597863 25.010902568965136 -6.8334049830783865 1.3125970868499868 1.149246334176585 0.2324340412300834 0.912521739350712 0.12701737455567985 0.17664470833075127 0.5939962139401807 0.0759496161646194 0.1747895449490725 1.4675571306092127e-07 6.8334049830783865 -0.9168122929465017 down AAAAAAALQAK(ub)SDEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAAAAAALQAKSDEK 15 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 182835700.0 76770000.0 44397700.0 61668000.0 True False 116465702.63878316 36474583.55418662 49479292.76995537 1.0 0.31317875329625633 0.424840031433243 26.79532992498385 -9.897772385335747 5.5855393152829755 1.000000440035002 0.3690093923693262 0.9770523352008719 0.045585525916904145 2.4981928073658316e-07 4.933807907325181e-08 0.04413802658403642 0.014712665224416412 1.2653993722195266e-10 9.897772385335747 -0.6309910476656758 AAAAAAALQAK(ub)SDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAAAAAALQAKSDEK 15 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 96894500.0 24129700.0 31567800.0 41197000.0 True False 33051102.170623753 30173030.215245172 31467117.078847915 1.0 0.912920545265911 0.952074666569404 24.978195046975667 -10.06459775483314 4.216150186371955 1.000007382300553 0.9324976059007846 0.7985082224575454 0.01598460314211213 22191986.61287278 3697.650320971189 1655.1365015945873 0.005471954813225735 8.617915772222527e-11 10.06459775483314 -0.06750977639976852 AAAAAAALQAK(ub)SDEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAAAAAALQAKSDEK 15 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 82596700.0 34917400.0 11545000.0 36134300.0 True False 29035365.20309883 11482804.793496935 43689815.063873656 1.0 0.3954765064319363 1.5047103681413594 24.791307844399412 -6.758746716114567 1.6174592048504144 0.648301508346298 1.508472628722144 0.6856959545461617 0.25421886569752167 0.28504374517700454 1.4695078104861965 0.12403336694741761 0.29840951212950617 1.7428230048492046e-07 6.758746716114567 0.860171120375846 AAAAAAALQAK(ub)SDEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAAAAAALQAKSDEK 15 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 179703200.0 76770000.0 57828000.0 45105200.0 True False 99380278.36293845 54609820.96510255 36896516.418434836 1.0 0.5495036023713534 0.371265979792169 26.5664562470763 -13.999999999999998 0.12803382810185684 3.140647265667286 0.11530970571821687 0.999654606046848 0.004917152875201395 11.940206196447958 0.11107398419553335 6.444074822958674 0.22747694377889086 1.0000000000000041e-14 13.999999999999998 -3.025337559949069 AAAAAAALQAK(ub)SDEK(ub)AAVAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAAAAAALQAKSDEKAAVAGK 21 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 2 8153100.0 1493600.0 2160400.0 4499100.0 True False 1446186.4855553042 3023058.986337165 3320650.7398931454 1.0 2.0903659497110954 2.296142837082375 20.46382216894283 -10.626449482558238 0.3370809864189736 4.1100930258764015e-16 2.339465847697898 0.9991774100648502 0.016312050034858548 2.2113170265332887 0.1635604845658729 1.9055791858201447 0.06391464676973618 2.3634723039376776e-11 10.626449482558238 2.3394658476978973 AAAAAAALQAK(ub)SDEK(ub)AAVAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAAAAAALQAKSDEKAAVAGK 21 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 2 6377800.0 1739600.0 1299100.0 3339100.0 True False 2382777.130922351 1241701.4664507846 2550473.3509231494 1.0 0.5211152358047575 1.0703784746901128 21.184212587092556 -6.676291466852784 1.9154110881208781 0.695998806891224 1.0682162808766646 0.3071407674112714 0.2031295241289371 0.446779085270104 3.1659007727615345 0.0852045552399197 0.2257659500948212 2.1072134669324865e-07 6.676291466852784 0.3722174739854407 AAAAAWEEPSSGNGTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAAAAWEEPSSGNGTAR 17 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 11472400.0 1102100.0 4752200.0 5618100.0 False True 1444863.772751582 4043190.2839305163 5036792.904620561 1.0 2.798319371127086 3.48599847238785 20.462502045689963 -9.46884980833466 0.2879327792111317 9.864128804694855e-23 3.7903395483879367 0.9987975976114011 0.036344347619351416 0.8557809578913006 0.11472809058918663 1.0683791704814443 0.25283732187185826 3.397427452008208e-10 9.46884980833466 3.7903395483879367 AAAAAWEEPSSGNGTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAAAAWEEPSSGNGTAR 17 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 8610540.0 2317100.0 778140.0 5515300.0 False True 2243544.9288164168 1088855.3599464928 4070677.474546608 1.0 0.48532808323161997 1.8143953447342354 21.09734864477218 -6.80171346082964 1.4489998035026879 0.7166483011914171 1.833508978258833 0.8371030354267175 0.22084018490391186 0.2183195708162013 0.9047907362350606 0.11989201962646169 0.27852704699535213 1.5786524908111205e-07 6.80171346082964 1.1168606770674159 AAAAAWEEPSSGNGTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAAAAWEEPSSGNGTAR 17 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 11940600.0 1102100.0 4428500.0 6410000.0 False True 1509576.1531326307 4232834.226908858 4896090.018093924 1.0 2.8039885355402556 3.2433541083261637 20.525712107212854 -9.951160973685123 0.3488285661632588 4.083583889021159e-21 3.3376682913177325 0.9987949318052873 0.03369642833880616 1.3127774189565187 0.15463757124040658 1.4881691119556089 0.13015313206868268 1.1190230344259509e-10 9.951160973685123 3.3376682913177325 AAAASAAEAGIATTGTEDSDDALLK(ub)MTISQQEFGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 AAAASAAEAGIATTGTEDSDDALLKMTISQQEFGR 35 1 P55036;H0Y3Y9 P55036 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 258597600.0 121658500.0 50709100.0 86230000.0 True False 117796517.50999612 70957508.07446314 63643776.155450255 1.0 0.6023735639590682 0.5402857189733941 26.81172164762785 -13.999999999999998 0.2613972095843159 3.932141511379679 0.5178948801399709 0.9995651978522506 0.004246709380261459 14.479324828155924 0.16179552633117478 22.445107862632504 0.02694564224126481 1.0000000000000041e-14 13.999999999999998 -3.4142466312397084 AAAASAAEAGIATTGTEDSDDALLK(ub)MTISQQEFGR ddPTM_RPMI8226_Bortezomib_8h_R1 2 AAAASAAEAGIATTGTEDSDDALLKMTISQQEFGR 35 1 P55036;H0Y3Y9 P55036 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 1104751000.0 205603000.0 530643000.0 368505000.0 True False 311914782.59270185 435945610.7173174 295669825.22852105 1.0 1.3976433149260994 0.947918603827785 28.216576687148585 -6.673293249052477 1.9254218593469394 1.2530848417353224 0.9496955969575337 0.29386899892744056 0.16878176897666738 0.45357963312131866 3.24481968933936 0.07048814664983216 0.18754062358727375 2.1218112656617656e-07 6.673293249052477 -0.3033892447777887 AAAASAAEAGIATTGTEDSDDALLK(ub)MTISQQEFGR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AAAASAAEAGIATTGTEDSDDALLKMTISQQEFGR 35 1 P55036;H0Y3Y9 P55036 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 252480000.0 121658500.0 57055000.0 73766500.0 True False 101164433.13537669 56747633.39046915 89190734.09224032 1.0 0.5609445101573429 0.881641218439752 26.592126923062125 -9.959922549847068 5.625079919127327 1.000000393214305 0.7212928642982432 0.5017533580314283 0.13092388291475654 6.455939436341372e-07 1.1921352029981737e-07 0.12676668398571614 0.04225550151231553 1.0966737546416453e-10 9.959922549847068 -0.27870752891606165 AAAASAAEAGIATTGTEDSDDALLK(ub)MTISQQEFGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AAAASAAEAGIATTGTEDSDDALLKMTISQQEFGR 35 1 P55036;H0Y3Y9 P55036 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 956395200.0 205603000.0 487667200.0 263125000.0 True False 266157136.54103458 460528091.6260786 215238949.8904929 1.0 1.730286467652454 0.8086912591851866 27.987703009241034 -6.695537011692225 1.8469882049519548 1.4554461219561041 0.8116660359607931 0.39639650113248226 0.3085210845365131 0.4048463976950501 2.681818991600211 0.1334289617314701 0.34502129313462754 2.0158721655353114e-07 6.695537011692225 -0.643780085995311 AAAASAAEAGIATTGTEGERDSDDALLK(ub)MTISQQEFGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAAASAAEAGIATTGTEGERDSDDALLKMTISQQEFGR 38 2 Q5VWC4 Q5VWC4 PSMD4 1 136314000.0 20878000.0 66594000.0 48842000.0 True False 31673452.386251338 54709780.39870321 39188357.29179095 1.0 1.7273071382155794 1.2372619446057496 24.916770792994292 -10.214625457950023 4.049041013530794 0.9997120699950366 1.4822845413944181 0.5635925819702027 0.20006011353800096 27500194.83709952 23125372.27480917 68365.14762221291 0.06848589820860182 6.100627977070408e-11 10.214625457950023 0.48257247139938153 AAAASAAEAGIATTGTEGERDSDDALLK(ub)MTISQQEFGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAAASAAEAGIATTGTEGERDSDDALLKMTISQQEFGR 38 2 Q5VWC4 Q5VWC4 PSMD4 1 155176000.0 20878000.0 91065000.0 43233000.0 True False 27026982.566906724 85997152.69743149 35365037.60804056 1.0 3.1818998841080757 1.3085085440260502 24.68789711508674 -6.6090508690153165 2.156825393924185 2.458637280841544 1.315097851693875 0.047536173784797464 0.9409095948507772 0.6153012008525457 5.422421569993213 0.36038776334630446 1.0449881214113024 2.460079437585452e-07 6.6090508690153165 -1.1435394291476693 AAAEAAAEAK(ub)AR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAAEAAAEAKAR 12 1 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 5153750.0 1711200.0 1512700.0 1929850.0 True False 2243399.7712843744 1287011.0564584164 1730167.6344283677 1.0 0.5736877898144683 0.7712257336274154 21.097255299270643 -10.07291988633638 4.82004552573592 1.0000100833910404 0.6724567617181486 0.7856768810483533 0.08064452787930323 111970099.50677536 8.392349368253836 13837.838024352905 0.027606766909357643 8.454347868869949e-11 10.07291988633638 -0.32755332167289175 AAAEAAAEAK(ub)AR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAAEAAAEAKAR 12 1 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 12660600.0 4158900.0 4992000.0 3509700.0 True False 6309355.356316718 4101138.5973259737 2816006.256643841 1.0 0.6500091317918952 0.44632234160413053 22.589061178057367 -9.723431723768172 0.11970483865174264 1.7029815309570608 2.0427290538597382e-12 0.9998890893735272 0.0024080347504134548 1.2207050877809946 0.05100651517484742 0.5005562076206286 0.22801374440433794 1.8904634110454202e-10 9.723431723768172 -1.702981530955018 AAAEAAAEAK(ub)AR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAAEAAAEAKAR 12 1 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 3945430.0 1711200.0 0.0 2234230.0 True False 2343876.8834412117 0.0 1706550.8894112266 1.0 0.0 0.7280889629773208 21.160465360793534 -10.655902301104463 9.036845910610346 1.0004941614425784 0.36404448314134574 0.5042731033936385 0.2972410744410981 0.002961337875104241 0.00011275892141866 0.2879955797981652 0.09593414425993103 2.2085015016832753e-11 10.655902301104463 -0.6364496783012327 AAAEAAAEAK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAAEAAAEAKAR 12 1 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 29352700.0 4158900.0 5447700.0 19746100.0 True False 5383778.03417512 5144530.706086827 16152512.412095638 1.0 0.9555614428065942 3.0002188629551214 22.360187500149816 -6.901932846569997 0.9489665356654078 0.9194400663633233 3.2234685596824546 0.9875036648117785 0.10659551634651253 0.10999654310947612 0.16950391248732716 0.08393035185341326 0.22056848132906293 1.253334958740516e-07 6.901932846569997 2.304028493319131 up AAAEVNQDYGLDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAAEVNQDYGLDPK 14 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 21033500.0 1551300.0 10981000.0 8501200.0 False True 2033769.322810571 9342677.603602752 7621577.3732686145 1.0 4.593774475215126 3.7475131952211584 20.955724622310143 -10.551064225607465 10.254011314664423 0.9999209767386489 4.170643835218142 0.9492810674394422 0.3454847208432977 0.0006241508192714471 2.732590267376982e-05 0.3345213103268495 0.11150471418293419 2.811485023398318e-11 10.551064225607465 3.170722858479493 AAAEVNQDYGLDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAAEVNQDYGLDPK 14 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 16711600.0 6174100.0 1038400.0 9499100.0 False True 5978106.575031468 1453038.5351844623 7011000.743108396 1.0 0.2430599918130121 1.172779483790232 22.511257186296493 -6.690219729439861 1.8658273936377259 0.5255415599626644 1.169558809670947 0.3713961102040598 0.3201181857533542 0.41618030340094203 2.8092943826075207 0.13725047914093685 0.3572854778749318 2.0407051973481787e-07 6.690219729439861 0.6440172497082827 AAAEVNQDYGLDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAAEVNQDYGLDPK 14 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 14045700.0 1551300.0 6215100.0 6279300.0 False True 2124857.5323061887 5940496.331412727 4796258.66624293 1.0 2.7957151202345694 2.2572142335761063 21.018934683833034 -10.047041494190987 5.306638094121805 0.9999866130763096 2.5264646769077785 0.9146298648007041 0.21984206640013698 76113341.08524746 8.941037319810444 12450.26860742751 0.07525778678363043 8.973430547447337e-11 10.047041494190987 1.526478063831469 AAAEVNQDYGLDPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAAEVNQDYGLDPK 14 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 8189130.0 6174100.0 1220200.0 794830.0 False True 5134037.709006178 1213626.5404092635 961025.2781213073 1.0 0.2363883183561952 0.1871870314539115 22.29166246173077 -13.653218522131626 0.3929039864657101 9.999999999997192 0.18375039951232436 0.9998204062881131 0.004986730352428789 19.41381143545993 0.20529301671278224 146.95168343550824 0.01284681401947205 2.2221914785424247e-14 13.653218522131626 -9.816249600484868 AAAIGIDLGTTYSCVGVFQHGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAAIGIDLGTTYSCVGVFQHGK 22 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 60943000.0 31545000.0 12801000.0 16597000.0 False True 30543621.24185999 17912506.056333136 12249747.8006727 1.0 0.5864565276819262 0.4010574811569637 24.86436778194429 -13.999999999999998 0.10844055402040101 3.001101010983331 0.053185188601791424 0.9997509882795229 0.003950709871840659 12.0220175915613 0.09966833278694805 5.282872962915637 0.30911460173325256 1.0000000000000041e-14 13.999999999999998 -2.9479158223815394 AAAIGIDLGTTYSCVGVFQHGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAAIGIDLGTTYSCVGVFQHGK 22 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 1686088000.0 218132000.0 705653000.0 762303000.0 False True 330922191.5852936 579723708.8579464 611633477.9207264 1.0 1.7518429516037017 1.8482697548649616 28.301916800874903 -11.178610028751413 0.36534999501797955 1.7062624180982947e-10 1.8612322339933185 0.999473323281454 0.008702404142025558 3.176951513267627 0.18327587151424932 2.6290144361107295 0.027289080028188344 6.628114027551762e-12 11.178610028751413 1.8612322338226923 AAAIGIDLGTTYSCVGVFQHGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAAIGIDLGTTYSCVGVFQHGK 22 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 1077885000.0 218132000.0 524705000.0 335048000.0 False True 282376174.02454656 495504705.4972356 274072701.88279283 1.0 1.7547681110452402 0.9705942890881725 28.073043122967352 -6.654839228147908 1.99101746842944 1.4878756174990215 0.9738697141961206 0.21400240727551656 0.3217616674781562 0.4967821926285891 3.7799858101094874 0.1308101361443697 0.3565620099661924 2.2139141287229611e-07 6.654839228147908 -0.514005903302901 AAAK(ub)HLIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAAKHLIER 9 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77;A0A0D9SF91;A0A0D9SES7;A0A0D9SG54;A0A0D9SEJ2;A0A0D9SFU3 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 4682800.0 1620000.0 1696700.0 1366100.0 True False 1568573.986743168 2374201.1581736123 1008277.4278784702 1.0 1.5136048272119882 0.6427987690730214 20.58102214937598 -6.74688166166503 1.661355307141697 1.303132258446261 0.641468231444496 0.6354584397613574 0.2157952387553655 0.305515177744731 1.6580923779619523 0.10265138857499351 0.25003417616570883 1.791093832114987e-07 6.74688166166503 -0.661664027001765 AAAK(ub)HLIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAAKHLIER 9 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77;A0A0D9SF91;A0A0D9SES7;A0A0D9SG54;A0A0D9SEJ2;A0A0D9SFU3 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 4217820.0 1620000.0 2058300.0 539520.0 True False 1347101.7781684815 2047211.52935944 652331.13754137 1.0 1.519715557159183 0.48424784831646417 20.361427424810255 -6.770262032651906 1.573657860228353 1.2979958837640633 0.4783943186533285 0.7314954593798118 0.21904725353584248 0.2660022265235323 1.3000912443520907 0.1097204792008937 0.2610954687951258 1.6972193219927565e-07 6.770262032651906 -0.8196015651107348 down AAALEFLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAALEFLNR 9 0 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 21394000.0 0.0 10282000.0 11112000.0 False True 0.0 8747965.678922081 9962236.833830602 0.0 AAALEFLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAALEFLNR 9 0 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 15572300.0 5182700.0 2220600.0 8169000.0 False True 5018178.025366549 3107297.16027602 6029293.835253068 1.0 0.619208235452956 1.201490621651005 22.258732222167243 -6.730225357819776 1.722147554609804 0.7709055051280039 1.2011764425952918 0.560454030120123 0.16007268566212532 0.33580165425923236 1.9511497048129778 0.0736517805205506 0.1827334996617812 1.8611211399533453e-07 6.730225357819776 0.43027093746728784 AAALEFLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAALEFLNR 9 0 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 8392200.0 0.0 8392200.0 0.0 False True 0.0 8021404.854705774 0.0 0.0 AAALEFLNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAALEFLNR 9 0 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 8612300.0 5182700.0 3429600.0 0.0 False True 4309644.682539373 3411124.0640776963 0.0 1.0 0.7915093506195409 0.0 22.03913749760152 -7.26412283037208 0.8429062191305311 0.98910900962055 3.6639261180408737e-17 0.9886666813694028 0.045857431706510084 0.0999851075109576 0.13784022318326222 0.038924277819226354 0.06862877119552346 5.443486743573826e-08 7.26412283037208 -0.98910900962055 down AAALSLSTLASPK(ub)GGSGTAGTEPSDIIIPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAALSLSTLASPKGGSGTAGTEPSDIIIPLR 31 1 P98172 P98172 EFNB1 Ephrin-B1 1 15137200.0 4470400.0 7592900.0 3073900.0 True False 4328489.598973242 10624784.56645042 2268753.37497667 1.0 2.454617095295948 0.5241443517652993 22.04543226212609 -6.705089501981478 1.8124294877667046 1.898686493941388 0.5292438944084586 0.4419328258632049 0.6134557177463329 0.3850069290630331 2.4620711282062904 0.26965634531357013 0.6892359227977624 1.9720162894271042e-07 6.705089501981478 -1.3694425995329293 AAANGDVAK(ub)VEDLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAANGDVAKVEDLLK 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 8523700.0 1899900.0 2417900.0 4205900.0 True False 2490787.298657773 2057158.74490038 3770713.813841627 1.0 0.8259070318886461 1.5138642371725504 21.248170396895066 -6.839652270043444 1.2842081847837095 0.9073870785735489 1.5363079951329996 0.9238206697447999 0.08060814503932807 0.1692082585215013 0.542252533611827 0.04922447397034782 0.11338069734728357 1.4465975657508822e-07 6.839652270043444 0.6289209165594507 AAANGDVAK(ub)VEDLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAANGDVAKVEDLLK 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 22040300.0 6313400.0 6609600.0 9117300.0 True False 6112984.572780432 9248847.748608654 6729205.616862887 1.0 1.5129839832724958 1.1008052673364055 22.54344549553028 -9.99436965430141 5.298075444120356 0.9999985576103949 1.3068946253054223 0.4250141192191732 0.1682712561499 2.8669490028537183e-06 5.439416893744575e-07 0.16292870789044203 0.054309314392339644 1.0130487516029976e-10 9.99436965430141 0.3068960676950274 AAANGDVAK(ub)VEDLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAANGDVAKVEDLLK 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 9577500.0 1899900.0 2454300.0 5223300.0 True False 2602344.3728669686 2345860.9107152335 3989664.117240241 1.0 0.9014413830752267 1.533103827009982 21.311380458417958 -6.86703732804695 1.1497127682739126 0.9451468922144156 1.5680632300686153 0.9616325912171021 0.05434989193749765 0.13972395483326647 0.3470554384115836 0.03675068078784846 0.08658481771251808 1.358196703199228e-07 6.86703732804695 0.6229163378541996 AAANGDVAK(ub)VEDLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAANGDVAKVEDLLK 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 18224900.0 6313400.0 8205500.0 3706000.0 True False 5249871.831042517 8161295.342835766 4480907.4653920485 1.0 1.5545703981910546 0.8535270211543873 22.323850770964555 -6.69588915653866 1.84593793247445 1.3457484137066493 0.8557919738779476 0.39796326981825514 0.23427186263074032 0.40410594924632076 2.674177035600977 0.1013701703411596 0.2619887904435346 2.0142382712512963e-07 6.69588915653866 -0.48995643982870174 AAAQYYLGNFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAAQYYLGNFR 11 0 O95801 O95801 TTC4 Tetratricopeptide repeat protein 4 0 10223800.0 2867500.0 3451600.0 3904700.0 False True 3759320.268909497 2936634.734231421 3500679.100527209 1.0 0.7811610940728068 0.9312000175879364 21.842040397896145 -10.130148780952712 4.81108013271482 1.0000093949326399 0.856180555906701 0.5505788772606381 0.061253134031404734 6.172985918908431e-06 1.1160778611265425e-06 0.05931196596896037 0.019769364000082158 7.410563261382735e-11 10.130148780952712 -0.1438288390259389 AAAQYYLGNFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAAQYYLGNFR 11 0 O95801 O95801 TTC4 Tetratricopeptide repeat protein 4 0 9605100.0 2867500.0 4118600.0 2619000.0 False True 3927692.241273762 3936626.633611112 2000446.1399981224 1.0 1.0022747180248655 0.5093184539706633 21.905250459419037 -6.905861730969327 0.9234678549487421 1.0173313891784213 0.4509468399175674 0.989263650980887 0.024023193736860866 0.10721820622419335 0.15408678040788584 0.019274232941014817 0.051796249636623985 1.2420476830825488e-07 6.905861730969327 -0.5663845492608539 AAASK(ub)LGEFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAASKLGEFAK 11 1 P30153;B3KQV6;C9J9C1;P30154;P30154-2;P30154-4;P30154-3 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 104579000.0 23367000.0 38485000.0 42727000.0 True False 30634363.286349922 32743188.013355073 38306019.90632473 1.0 1.068838536231135 1.2504265079141745 24.86864753043876 -6.954301132114787 0.5094413266399498 0.9966426112230516 1.3305813907992425 0.999497019705218 0.0023690641856082785 0.0818032134890498 0.029160072210260755 0.002731336702884242 0.014986337616522528 1.1109611393458441e-07 6.954301132114787 0.3339387795761909 AAASK(ub)LGEFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAASKLGEFAK 11 1 P30153;B3KQV6;C9J9C1;P30154;P30154-2;P30154-4;P30154-3 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 241786000.0 31099000.0 50720000.0 159967000.0 True False 30111779.26773194 70972760.5013059 118066843.79286663 1.0 2.3569766459254358 3.9209520879886415 24.843824621855433 -6.9692660735278045 0.27515031484109925 0.6346973713210701 5.690575924194602 0.999976079219173 0.0058371315450947885 0.07654157135824964 0.009879387567161071 0.029719872721540638 0.14445354860674564 1.0733316267946306e-07 6.9692660735278045 5.055878552873532 AAASK(ub)LGEFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAASKLGEFAK 11 1 P30153;B3KQV6;C9J9C1;P30154;P30154-2;P30154-4;P30154-3 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 254096000.0 48857000.0 53829000.0 151410000.0 True False 74119640.92514041 44222794.38210342 121483747.13463955 1.0 0.5966406991470412 1.6390223376464557 26.143352556413546 -6.801792635136407 1.4486350442180675 0.777949773344102 1.6540467554208071 0.8373284902235253 0.1730913553554484 0.21821549249482589 0.903888490405056 0.09399168452186318 0.21835053673887325 1.578364719887434e-07 6.801792635136407 0.8760969820767052 AAASK(ub)LGEFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAASKLGEFAK 11 1 P30153;B3KQV6;C9J9C1;P30154;P30154-2;P30154-4;P30154-3 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 105419000.0 23367000.0 31767000.0 50285000.0 True False 32006411.369431276 30363428.90057888 38408718.652083114 1.0 0.9486670826701434 1.2000320251075247 24.931857591961652 -6.853522078085596 1.218104520847123 0.972502717027106 1.2107768394229497 0.945256443729644 0.025371969365670204 0.15362846521388837 0.4369064828237661 0.016283398867536474 0.03777250481305788 1.401128354428594e-07 6.853522078085596 0.23827412239584367 AAASK(ub)LGEFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAASKLGEFAK 11 1 P30153;B3KQV6;C9J9C1;P30154;P30154-2;P30154-4;P30154-3 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 202788000.0 31099000.0 100462000.0 71227000.0 True False 25860196.41929727 99920791.26585428 86120236.38356157 1.0 3.8638836939108425 3.330223598738691 24.62422989728971 -10.530677091426243 8.541733244080898 0.999745522247895 3.597053646324767 0.9693035136025162 0.21786582154281336 0.0010558898146595156 5.801568163489478e-05 0.21096304676226382 0.07031589154525944 2.9466116974106245e-11 10.530677091426243 2.597308124076872 AAASK(ub)LGEFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAASKLGEFAK 11 1 P30153;B3KQV6;C9J9C1;P30154;P30154-2;P30154-4;P30154-3 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 221365000.0 48857000.0 45131000.0 127377000.0 True False 63246349.61544984 42619420.17666258 104195692.99838969 1.0 0.6738637160215092 1.6474578158568813 25.914478878505996 -6.816374160928362 1.3874773974209413 0.8235426384078397 1.6671053445763848 0.8758373014549126 0.14257464810612058 0.1982391624683974 0.7508342703785705 0.08076914963935661 0.18636476691934675 1.5262505697371741e-07 6.816374160928362 0.8435627061685451 AAASTDYYK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAASTDYYKR 10 1 P08559;P08559-4;P08559-3;P08559-2 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1 3345670.0 427910.0 699840.0 2217920.0 True False 414326.2312760914 979289.7616173874 1636980.2158262322 1.0 2.3635717164256143 3.950945154460689 18.660407635651715 -6.969127302185297 0.27824025797337837 0.6428015692235758 5.719970079922332 0.9999747534400731 0.00605901952251407 0.0765868876915814 0.010039542973888736 0.029621137855982124 0.14602740272582462 1.0736746462811397e-07 6.969127302185297 5.0771685106987565 AAASTDYYK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAASTDYYKR 10 1 P08559;P08559-4;P08559-3;P08559-2 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1 3409330.0 427910.0 1250000.0 1731420.0 True False 355826.1246272063 1243266.0018944258 2093451.91681843 1.0 3.4940267615172353 5.883356425871507 18.44081291108599 -7.137723934512368 0.23398851742247279 5.02588337044272e-14 9.0509397811779 0.9999846912485417 0.00780092017839524 0.08381965981447341 0.01006704844658847 0.08280154908757355 0.27622925815736066 7.2824257522755e-08 7.137723934512368 9.050939781177851 AAASTDYYK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAASTDYYKR 10 1 P08559;P08559-4;P08559-3;P08559-2 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 1 3484740.0 708940.0 676600.0 2099200.0 True False 917736.8052966202 638946.6152207992 1717167.139610918 1.0 0.6962198873720514 1.8710888892114501 19.807720941653244 -6.8380666058651185 1.2913713232349122 0.8383355976216993 1.9082692290369319 0.9210755692323526 0.13988551271345034 0.17106794635960026 0.5549972479731684 0.08496658363981961 0.19565398029511083 1.4518889305902133e-07 6.8380666058651185 1.0699336314152326 AAATPESQEPQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAATPESQEPQAK 13 0 P49006 P49006 MARCKSL1 MARCKS-related protein 0 5237110.0 2103300.0 623510.0 2510300.0 False True 2036531.8927882095 872480.7945616964 1852777.1226142498 1.0 0.4284149920024997 0.9097707377799119 20.957682976941765 -10.172444998973699 7.728053335537249 1.000000133142573 0.6690928648912107 0.3865457259981533 0.19651266031858639 4.509722353719934e-07 4.8061555257724946e-08 0.19027264173475975 0.06342418839440005 6.72287445256883e-11 10.172444998973699 -0.3309072682513623 AAATQPDAK(ub)DTPDEPWAFPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAATQPDAKDTPDEPWAFPAR 21 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 18953600.0 6538800.0 6069400.0 6345400.0 True False 8572430.121829271 5163869.178335902 5688838.8773748 1.0 0.6023810173950982 0.6636203266199221 23.03127280840328 -10.52477871833758 6.250789512908221 1.0003927869635592 0.6330006720075335 0.9795442515088849 0.02500084330022228 0.00013699321757619103 1.0414999750942526e-05 0.02423209301082406 0.00806898747857517 2.986904118227906e-11 10.52477871833758 -0.36739211495602564 AAATQPDAK(ub)DTPDEPWAFPAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAATQPDAKDTPDEPWAFPAR 21 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 27008400.0 8485900.0 9293100.0 9229400.0 True False 8216519.749446809 13003883.29287628 6811943.26393496 1.0 1.5826510115492376 0.8290545719668702 22.970096013910265 -6.700281634340818 1.8300132039921282 1.3617106214999373 0.8312973519555709 0.418814079893178 0.24593264321193634 0.3949548396635144 2.5717188442745154 0.10720781765209868 0.27559926800048506 1.9939688326750923e-07 6.700281634340818 -0.5304132695443664 AAATQPDAK(ub)DTPDEPWAFPAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAATQPDAKDTPDEPWAFPAR 21 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 89461000.0 13546000.0 20164000.0 55751000.0 True False 20550272.345251463 16565576.657948924 44731790.413468674 1.0 0.8061001031831444 2.1767006131091406 24.292654177755484 -6.871057657033019 1.1284309671420638 0.8895936058100284 2.258618925899568 0.9657301684102473 0.11210943951285274 0.13584761559131672 0.322649265358915 0.0770501840771798 0.18276952615961345 1.345681689192938e-07 6.871057657033019 1.3690253200895395 up AAATQPDAK(ub)DTPDEPWAFPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAATQPDAKDTPDEPWAFPAR 21 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 23645600.0 6538800.0 10103000.0 7003800.0 True False 8956371.064425768 9656616.053846715 5349646.687788798 1.0 1.07818400827566 0.5973006979397394 23.09448286992617 -6.865214299777277 1.1591943615372842 1.0431609958298955 0.5715945325553726 0.9596644227500284 0.042315220932079 0.14152153363037898 0.3584540310303957 0.028406075963801444 0.06674396050636489 1.3639099580488067e-07 6.865214299777277 -0.4715664632745229 AAATQPDAK(ub)DTPDEPWAFPAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAATQPDAKDTPDEPWAFPAR 21 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 29280500.0 8485900.0 12358000.0 8436600.0 True False 7056401.8391110515 12291425.00112905 10200654.053568948 1.0 1.7418828010902359 1.4455885997067879 22.75050128934454 -10.036021715219682 4.4743613733078185 0.999973715215605 1.5937356999968941 0.842618941561341 0.12096160138654537 17888795.96435775 13374896.124779304 4463.302067963583 0.041408375583399215 9.204035493748246e-11 10.036021715219682 0.5937619847812892 AAATQPDAK(ub)DTPDEPWAFPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAATQPDAKDTPDEPWAFPAR 21 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 89804000.0 13546000.0 18308000.0 57950000.0 True False 17535564.031579558 17289143.705974557 47403694.61721255 1.0 0.9859473966642176 2.703288843851494 24.063780499847933 -6.905053730613188 0.9287511504572507 0.9381578934455229 2.9032660445376033 0.9889175677475482 0.08487864160661455 0.10778076186237039 0.15717758202414672 0.06783473432457329 0.18142130040383977 1.2443606508077885e-07 6.905053730613188 1.9651081510920805 up AAAYSK(ub)LGNYAGAVQDCER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAAYSKLGNYAGAVQDCER 19 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 82219000.0 10395000.0 29203000.0 42621000.0 True False 13627945.665323192 24846026.23240243 38210987.769500956 1.0 1.823167397535496 2.8038699821595428 23.70006476473869 -6.968802314125047 0.28534494454756953 0.7973887026883764 3.8597531687137345 0.9999714755849884 0.003938119238512252 0.07669325959539303 0.010414465515449339 0.0175749464943787 0.08942470839125156 1.0744783913036035e-07 6.968802314125047 3.0623644660253584 AAAYSK(ub)LGNYAGAVQDCER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAAYSKLGNYAGAVQDCER 19 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 80952000.0 21305000.0 17601000.0 42046000.0 True False 20628684.43676737 24629171.088002436 31032891.247037638 1.0 1.1939283459154977 1.504356292916402 24.29814848266957 -6.964154762475957 0.37227771092127676 0.9767358488494237 1.7323930304202901 0.9998946413966215 0.0021321769415759023 0.07824901004927924 0.015878771697842225 0.004078057297792525 0.02633260545181557 1.0860385407234844e-07 6.964154762475957 0.7556571815708665 AAAYSK(ub)LGNYAGAVQDCER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAAYSKLGNYAGAVQDCER 19 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 73133000.0 10395000.0 24216000.0 38522000.0 True False 14238312.414312392 23146057.048396695 29423896.985493574 1.0 1.6256180068875448 2.066529805591047 23.763274826261583 -7.623511262876279 0.11343085359338675 8.739774541979727e-20 3.4164561776420057 0.9999931613414346 0.001144293616815612 0.13968991950109813 0.012223034792181446 0.14553771627647813 0.20468871860126314 2.3795165904129865e-08 7.623511262876279 3.4164561776420057 AAAYSK(ub)LGNYAGAVQDCER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAAYSKLGNYAGAVQDCER 19 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 76639700.0 21305000.0 8415700.0 46919000.0 True False 17716051.471530527 8370362.953714331 56729545.97105495 1.0 0.47247339324823023 3.2021551790035505 24.078553758103848 -6.856605684271935 1.2027659786335172 0.7159861524000802 3.3260208320512707 0.9493782435565099 0.2659924296061288 0.15034124965882806 0.41522103936979554 0.172707881714336 0.40173437927181976 1.391215205561852e-07 6.856605684271935 2.6100346796511906 up AADEIEK(ub)EK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AADEIEKEK 9 1 Q96BN8 Q96BN8 OTULIN Ubiquitin thioesterase otulin 1 36174300.0 12710200.0 14081500.0 9382600.0 True False 16663195.285751872 11980595.0892571 8411778.556254415 1.0 0.7189854576991783 0.5048118570300283 23.990161738438232 -7.310537927165919 0.14562195250494916 1.290147716067219 2.48183831000088e-10 0.9999943659678944 0.00048126893568109264 0.10971691137906622 0.008734824668217454 0.025230203755451097 0.048128842498001555 4.891725435730386e-08 7.310537927165919 -1.290147715819035 AADEIEK(ub)EK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AADEIEKEK 9 1 Q96BN8 Q96BN8 OTULIN Ubiquitin thioesterase otulin 1 30280800.0 12710200.0 9271600.0 8299000.0 True False 17409504.42023985 8861950.054918857 6338947.123270111 1.0 0.5090294267432551 0.36410841861188253 24.053371799961123 -13.999999999999998 0.1710387335226747 3.482783275169227 0.23767494248434867 0.999511734653867 0.006012817191888891 12.101775947871072 0.13098367692860555 9.969826287618737 0.11704398034794362 1.0000000000000041e-14 13.999999999999998 -3.2451083326848784 AADEIEK(ub)EK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AADEIEKEK 9 1 Q96BN8 Q96BN8 OTULIN Ubiquitin thioesterase otulin 1 16591900.0 2485300.0 9887200.0 4219400.0 True False 2066637.0674581043 9833935.691144459 5101657.0316986535 1.0 4.7584241306771276 2.468579080493085 20.97885362139098 -10.316639900441057 7.058170146568586 0.9999607399438009 3.6135016055851064 0.6346216578242583 0.934825327164774 0.0005775418279604874 5.591538095296869e-05 0.9051539547351728 0.30171357697683926 4.823475751182692e-11 10.316639900441057 2.6135408656413057 AADEVLAEAK(ub)KPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AADEVLAEAKKPR 13 2 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2;A0A2R8Y640 A0A3B3IRP5 CDC73 Parafibromin 1 3675670.0 816070.0 683700.0 2175900.0 True False 790164.304544133 956704.975448399 1605966.5143992123 1.0 1.2107671403865146 2.0324462965025196 19.591793148871428 -6.945466381574786 0.6065902527208348 0.9908628371866947 2.294890517436946 0.9987956549069947 0.015457424341485376 0.08535914089479155 0.043903628919623405 0.01576327540058711 0.06920391707672925 1.1337926007828235e-07 6.945466381574786 1.3040276802502513 up AADEVLAEAK(ub)KPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AADEVLAEAKKPR 13 2 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2;A0A2R8Y640 A0A3B3IRP5 CDC73 Parafibromin 1 1395780.0 259410.0 628140.0 508230.0 True False 355320.88729165785 600386.6978187944 388196.54132540955 1.0 1.689702799053238 1.0925238431220239 18.438762973425035 -10.287720609811396 4.150017565044209 0.9995690798997333 1.3911133211027853 0.36383513780180077 0.24379728791367733 172858132.2057987 507.5839451483486 714963.6018380481 0.08345829627261524 5.155602079494567e-11 10.287720609811396 0.391544241203052 AADEVLAEAK(ub)KPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AADEVLAEAKKPR 13 2 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2;A0A2R8Y640 A0A3B3IRP5 CDC73 Parafibromin 1 2636990.0 816070.0 1083100.0 737820.0 True False 678598.3630308342 1077265.1253214816 892094.7507057646 1.0 1.587485593849764 1.3146137675920528 19.372198424305704 -10.013745330406334 4.38793833953007 0.9999793732914161 1.4510496806916917 0.7846262630545723 0.11139945685449788 14500447.588090828 8272894.105688349 2709.2450128001537 0.0381349976882362 9.688458193666696e-11 10.013745330406334 0.45107030740027565 AADTNEVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AADTNEVVK 9 0 Q5T1B5;Q14642 Q5T1B5 INPP5A Type I inositol 1,4,5-trisphosphate 5-phosphatase 0 4478140.0 972940.0 1781100.0 1724100.0 False True 1275533.7619643626 1515366.8226734244 1545706.6707350013 1.0 1.188025646878771 1.2118116484463444 20.282669655308013 -13.191373021720132 0.3022462588532942 1.0268314770790503e-10 1.2176766021145344 0.9996108354222233 0.0018689810847319684 10.36264542921003 0.1722661160577579 6.38316557082091 0.008517145279436292 6.436162168969068e-14 13.191373021720132 1.2176766020118512 AADTNEVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AADTNEVVK 9 0 Q5T1B5;Q14642 Q5T1B5 INPP5A Type I inositol 1,4,5-trisphosphate 5-phosphatase 0 5073140.0 972940.0 2271800.0 1828400.0 False True 1332662.210714873 2171424.364162029 1396569.5770800181 1.0 1.6293884126850295 1.0479546623677907 20.345879716830904 -10.256608204862623 4.583392133728925 0.9998674063904892 1.338671537528251 0.3114711381433911 0.23736933459128526 0.0003217402571441379 5.2183741491292986e-05 0.22992138955721636 0.07661062331348026 5.538495346346881e-11 10.256608204862623 0.33880413113776175 AAEAAEAAAAAAAAGSGK(ub)LEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAEAAEAAAAAAAAGSGKLEER 22 1 E9PJD7 E9PJD7 CYHR1 1 11689300.0 4593100.0 5031300.0 2064900.0 True False 3819366.158830646 5004195.388265145 2496661.0429811203 1.0 1.3102161929918894 0.6536846532005481 21.86490180565189 -6.778177198945272 1.5426640656407 1.1760617372630535 0.6487479937623934 0.7610254913232332 0.13109148464647813 0.2533972179529623 1.1909391889986685 0.06693485811919955 0.1582008247983197 1.6665670883562197e-07 6.778177198945272 -0.5273137435006601 AAEAAEAAAAAAAAGSGK(ub)LEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAEAAEAAAAAAAAGSGKLEER 22 1 E9PJD7 E9PJD7 CYHR1 1 21805300.0 9102500.0 7998000.0 4704800.0 True False 11783365.68709973 7552904.269192955 3848574.675324617 1.0 0.6409802148007485 0.3266108154088763 23.49024833976021 -7.527193577411626 0.2511945208595226 1.133666124942846 1.291686604031485e-11 0.9998536378665678 0.0033282981869180105 0.127573389566401 0.025800802917446755 0.028281086208351895 0.06722438692747987 2.9703417707594127e-08 7.527193577411626 -1.1336661249299291 down AAEAK(ub)ATTVPDFQETRPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAEAKATTVPDFQETRPR 18 2 Q9NR46;B7ZC38 Q9NR46 SH3GLB2 Endophilin-B2 1 11429710.0 4281810.0 4871500.0 2276400.0 True False 4145886.2852943013 6816715.354536891 1680142.5494638379 1.0 1.6442118489154358 0.40525533838769306 21.983249115609453 -6.765397400005834 1.592082855523258 1.3716702995055168 0.3994682639742131 0.712644402899381 0.2712099528610013 0.2739372406770043 1.3695791028457591 0.13433286655420426 0.3211356671468414 1.716337138668787e-07 6.765397400005834 -0.9722020355313037 AAEAK(ub)ATTVPDFQETRPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAEAKATTVPDFQETRPR 18 2 Q9NR46;B7ZC38 Q9NR46 SH3GLB2 Endophilin-B2 1 85733300.0 10922300.0 22095000.0 52716000.0 True False 16569927.62708843 18151974.62097704 42296659.4937564 1.0 1.0954770008350725 2.5526158258295615 23.982063965487338 -6.920216431716568 0.8231319348970196 0.9680995118115878 2.7887571146952754 0.9942406068410068 0.05391849636242726 0.09804442874558275 0.10495940586469449 0.046509627616449556 0.13960545033127642 1.2016654324673112e-07 6.920216431716568 1.8206576028836876 up AAEAK(ub)ATTVPDFQETRPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAEAKATTVPDFQETRPR 18 2 Q9NR46;B7ZC38 Q9NR46 SH3GLB2 Endophilin-B2 1 17681910.0 4281810.0 8086600.0 5313500.0 True False 3560514.731345426 8043035.880735577 6424528.283151817 1.0 2.2589531254927073 1.804381885178763 21.76365439104373 -10.229034227275001 5.0667219266308745 0.9998719821396989 2.031667505336351 0.8728988212279261 0.1855779317543466 0.00026839752908362037 4.0839776667817895e-05 0.17970694555389344 0.05989501992537649 5.901545675415718e-11 10.229034227275001 1.0317955231966522 AAEAK(ub)ATTVPDFQETRPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAEAKATTVPDFQETRPR 18 2 Q9NR46;B7ZC38 Q9NR46 SH3GLB2 Endophilin-B2 1 45706800.0 10922300.0 26431300.0 8353200.0 True False 14139132.6607206 24960374.92002001 6833003.311069886 1.0 1.7653398917008185 0.483268915783809 23.753190287579788 -6.74499993922329 1.668223058241314 1.4527118872441844 0.48164097052730925 0.6272455339301934 0.32155307420732826 0.30884176733131297 1.6893806888021796 0.15236799072182045 0.3718893676585523 1.79887116686918e-07 6.74499993922329 -0.9710709167168752 AAECNIVVTQPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAECNIVVTQPR 12 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 13494700.0 1348500.0 5323700.0 6822500.0 False True 1767896.5588925742 4529424.711620066 6116573.146041155 1.0 2.562041703648848 3.459802619827842 20.75360243322856 -8.719813104764112 0.22426104680555123 8.56492864184755e-22 4.277099529101099 0.9994672530039646 0.023458529925790138 0.27907717151942585 0.0664176719785722 0.6124798894392567 0.40703252060735184 1.9062808945559803e-09 8.719813104764112 4.277099529101099 AAECNIVVTQPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAECNIVVTQPR 12 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 15386100.0 1348500.0 6392700.0 7644900.0 False True 1847076.8918422556 6110249.376168053 5839332.071657747 1.0 3.308064435841516 3.161390896853058 20.816812494751453 -10.178851371697409 5.148748255590981 0.9998677680721085 3.23472766634887 0.9967795636254687 0.059879221553841164 9.089520887250012e-05 1.4496859123483244e-05 0.057981092615563105 0.0193259356543645 6.624431723856278e-11 10.178851371697409 2.2348598982767616 AAEDDEDDDVDTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAEDDEDDDVDTK 13 0 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 79987200.0 1025200.0 42908000.0 36054000.0 False True 1344047.1280509236 36506293.65407401 32323477.93438886 1.0 27.161468442712863 24.049363493126098 20.358152295397176 -9.938030276071654 13.008864140894461 1.0000119143655812 25.60541596791948 0.9881442601387965 1.2705115254315449 0.0 1.8673104830183637e-17 1.2301674947818242 0.4100558315939415 1.1533728496701654e-10 9.938030276071654 24.605404053553897 AAEDDEDDDVDTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAEDDEDDDVDTK 13 0 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 66060000.0 22531000.0 6566000.0 36963000.0 False True 21815765.737845868 9187838.041237652 27281281.433769025 1.0 0.4211558811020162 1.250530545734712 24.378867777706127 -6.719029184549673 1.7625940385803978 0.6474817977048192 1.2491877158389608 0.5080483507904172 0.24360856581948065 0.35719734025100003 2.1681823039918786 0.10975841287635146 0.2758721157586761 1.9097249209132022e-07 6.719029184549673 0.6017059181341416 AAEDDEDDDVDTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAEDDEDDDVDTK 13 0 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 74582400.0 1025200.0 38564200.0 34993000.0 False True 1404244.1449882714 36860306.129244335 26728374.103457194 1.0 26.24921475428491 19.03399362486246 20.421362356920067 -9.938282063914672 9.083995891653245 1.0002998665637126 22.64160418957078 0.923050284689556 2.9456016964934335 2.736833503994369e-07 7.485533755282238e-08 2.8520664065253825 0.9506888588236178 1.1527043606442292e-10 9.938282063914672 21.64130432300707 AAEDDEDDDVDTK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAEDDEDDDVDTKK 14 1 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 1 111340000.0 50806000.0 35056000.0 25478000.0 True False 49193191.33979837 49054043.614624925 18804547.476383638 1.0 0.9971714027615673 0.3822591493707453 25.55195531514093 -6.9079073013604155 0.9098439458447044 1.020322179354147 0.306242941773598 0.9901080615960615 0.02889673295788183 0.10581915359992558 0.14638531843263478 0.023415967293649937 0.06374066328319986 1.2362112702618656e-07 6.9079073013604155 -0.714079237580549 down AAEDDEDDDVDTK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAEDDEDDDVDTKK 14 1 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 1 85555000.0 37060000.0 28671000.0 19824000.0 True False 50762083.50884245 27404220.417681772 15141979.488095753 1.0 0.5398560997384617 0.29829310464488934 25.59724794943048 -9.581546944574342 0.1723221475566937 1.5689746901007289 3.604439519199818e-22 0.9996605969345377 0.0053622855209788265 1.0232993524569294 0.06984795427038633 0.4542520780860279 0.16678634818093388 2.6209157183814363e-10 9.581546944574342 -1.5689746901007289 AAEDDEDDDVDTK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAEDDEDDDVDTKK 14 1 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 1 112433000.0 50806000.0 47379000.0 14248000.0 True False 42247440.0874246 47123759.92300482 17227190.92469127 1.0 1.1154228475261323 0.40776887046983773 25.332360590575206 -6.8650676931948125 1.1599374709665993 1.063681277046135 0.3700432600248825 0.9595039318964498 0.062380898297386043 0.1416679739834742 0.35937023167096754 0.04185199828867838 0.09831756142016737 1.364370456489897e-07 6.8650676931948125 -0.6936380170212525 down AAEDDEDDDVDTKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAEDDEDDDVDTKK 14 1 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 151187900.0 1303900.0 78380000.0 71504000.0 False True 1709425.5269855598 66686009.52284708 64105451.9948005 1.0 39.010772022600314 37.50116690245379 20.70508014085887 -9.683193151676349 14.476727382470942 1.0000017781904937 38.25596946252707 0.9987701226930676 0.6162937095761682 0.0 0.0 0.5967237383630879 0.19890793946327848 2.0739909086432674e-10 9.683193151676349 37.255967684336575 AAEDDEDDDVDTKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAEDDEDDDVDTKK 14 1 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 125381540.0 42769540.0 12393000.0 70219000.0 False True 41411844.36356253 17341589.52864124 51826537.375154264 1.0 0.4187591689082016 1.2514906827177061 25.303540121807302 -6.719059067829032 1.7628481699180312 0.6460173239254341 1.2501094865298903 0.507971134576992 0.2446177227731049 0.35716716880314614 2.1687154443277303 0.11020475269797475 0.2769464168402314 1.9095935195661586e-07 6.719059067829032 0.6040921626044562 AAEDDEDDDVDTKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAEDDEDDDVDTKK 14 1 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 170773900.0 1303900.0 86510000.0 82960000.0 False True 1785987.0665725747 82687702.14968614 63366556.61483172 1.0 46.298040841006326 35.47985189861216 20.76829020238176 -9.35047536314441 8.610593582429551 1.0000004753017662 40.888946369820125 0.9477188905297662 4.41650714168581 0.0 0.0 4.276264652021604 1.4254215506738677 4.4619493581299503e-10 9.35047536314441 39.88894589451836 AAEEQGDDQDSEK(ub)SKPAGSDGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAEEQGDDQDSEKSKPAGSDGER 23 2 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 33400300.0 15436000.0 10699000.0 7265300.0 True False 20236745.482436646 9102750.904375363 6513556.449678677 1.0 0.44981298560460664 0.321867785278604 24.270473955534214 -13.999999999999998 0.2049278035380879 4.117466543280528 0.24269554844064348 0.9994877998310173 0.006658097832833625 12.632710610541631 0.14351621187388053 15.81918290453525 0.07857419197887397 1.0000000000000041e-14 13.999999999999998 -3.874770994839885 AAEEQGDDQDSEK(ub)SKPAGSDGER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAEEQGDDQDSEKSKPAGSDGER 23 2 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 44706500.0 20424000.0 15503000.0 8779500.0 True False 19775651.299532354 21693428.74707697 6479885.570645649 1.0 1.0969767022333148 0.3276698942804924 24.23722187401111 -6.875286527112771 1.1058063627494426 1.0570528723713413 0.2778588303946611 0.9696777788159952 0.059570071318594195 0.1318843814776102 0.2982469920591201 0.04166005801687615 0.09963890784450398 1.332641927479593e-07 6.875286527112771 -0.7791940419766802 down AAEEQGDDQDSEK(ub)SKPAGSDGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAEEQGDDQDSEKSKPAGSDGER 23 2 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 39443000.0 15436000.0 13135000.0 10872000.0 True False 21143106.34221513 12554652.268363513 8304257.515868497 1.0 0.5937941220726123 0.3927643072620744 24.333684017057106 -12.014793578499571 0.1132244970958275 2.3022354822220237 1.6039334415654734e-08 0.9997970193204984 0.003598477131336592 5.588370089848352 0.08112356089096187 2.0330553676680565 0.2945472463761541 9.665101550771637e-13 12.014793578499571 -2.3022354661826894 AAEEQGDDQDSEK(ub)SKPAGSDGER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAEEQGDDQDSEKSKPAGSDGER 23 2 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 39980100.0 20424000.0 15039000.0 4517100.0 True False 16983460.936612982 14957981.921992237 5461604.725289376 1.0 0.880738147414099 0.3215837305289899 24.017627149445385 -6.941250004705377 0.6478301505922738 1.0061659807374808 0.16508608153077853 0.9983230858681088 0.012110334829197239 0.08720097505605234 0.05204727713242102 0.01190330028704055 0.04786646945336951 1.1448537085429978e-07 6.941250004705377 -0.8410798992067022 down AAEEVEAK(ub)FK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAEEVEAKFK 10 1 C9JRZ6;Q9NX63;F8WAR4 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 7632500.0 1242200.0 3365000.0 3025300.0 True False 1628536.2294819136 2862955.116667264 2712270.976726757 1.0 1.7579928925364199 1.6654655436125065 20.635144384552305 -10.065736009172396 4.2524830914138825 0.9999250213809969 1.7117292181941064 0.9874829627621338 0.03777413249923901 26412014.846835572 44283186.94118708 26764.55560218049 0.01382391505762678 8.595358413523143e-11 10.065736009172396 0.7118041968131095 AAEEVEAK(ub)FK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAEEVEAKFK 10 1 C9JRZ6;Q9NX63;F8WAR4 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 9397900.0 3535300.0 3598800.0 2263800.0 True False 3423073.8366253837 5035819.607494076 1670842.8674557365 1.0 1.4711396387694071 0.48811183959237253 21.706860981328482 -6.776392952787806 1.5501306479404238 1.2680181183080126 0.48121372043137034 0.7543721948538085 0.19895427482616637 0.2562067499174961 1.2157625511796712 0.10112048879611495 0.23931093787041274 1.6734280610110726e-07 6.776392952787806 -0.7868043978766422 down AAEEVEAK(ub)FK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAEEVEAKFK 10 1 C9JRZ6;Q9NX63;F8WAR4 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 17920400.0 7712200.0 3287600.0 6920600.0 True False 11699971.237343004 2700902.0938639618 5552740.376593267 1.0 0.23084690031061317 0.4745943612981276 23.48000164737119 -10.211820750688583 5.394792961003898 1.0000362266269416 0.35272063080856414 0.9038690064712129 0.09950948425336875 4.3360404241659764e-05 6.334891356080635e-06 0.09635501659012238 0.03211654794187086 6.140153796109834e-11 10.211820750688583 -0.6473155958183774 AAEEVEAK(ub)FK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAEEVEAKFK 10 1 C9JRZ6;Q9NX63;F8WAR4 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 6781500.0 1242200.0 3014100.0 2525200.0 True False 1701474.9091927735 2880927.0957041834 1928799.7681264835 1.0 1.6931939931285702 1.1336045907615289 20.698354446075196 -10.221615015533823 3.676294287726689 0.9994351606083781 1.4133992919563874 0.4211884252803354 0.2284514180379399 43801428.75307262 81034417.39806251 291733.70614150463 0.08131368508876473 6.003230024794775e-11 10.221615015533823 0.41396413134800925 AAEEVEAK(ub)FK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAEEVEAKFK 10 1 C9JRZ6;Q9NX63;F8WAR4 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 12278500.0 3535300.0 6219700.0 2523500.0 True False 2939758.5903450823 6186193.241586205 3051152.1826542974 1.0 2.1043201512883547 1.0378920883759164 21.48726625676276 -6.638066498630668 2.0519479082029184 1.7232331366983435 1.0423495138057917 0.1471005347495944 0.4727380148575434 0.5382211961318383 4.328929802174028 0.1877929401794982 0.5233234825666258 2.3010894504788386e-07 6.638066498630668 -0.6808836228925519 AAEEVEAK(ub)FK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAEEVEAKFK 10 1 C9JRZ6;Q9NX63;F8WAR4 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 18463500.0 7712200.0 7074500.0 3676800.0 True False 9983594.930189567 6680797.856014696 3007660.127153879 1.0 0.6691775760865973 0.30126023222947107 23.25112796946364 -7.270900172867579 0.31081819911919184 1.0688041738156784 8.902484316143366e-15 0.9998613941510597 0.0033599582281720634 0.1000838632109975 0.02045034007341361 0.011935140418606308 0.04660979927492708 5.3591983013896494e-08 7.270900172867579 -1.0688041738156695 down AAEK(ub)LYLADPMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAEKLYLADPMK 12 1 P49458;Q6P2S0;Q659G3;E9PE20;P49458-2 P49458 SRP9;DKFZp564M2223 Signal recognition particle 9 kDa protein 1 12508300.0 5018000.0 5000500.0 2489800.0 True False 4858706.336714328 6997225.7272630045 1837646.687601066 1.0 1.4401417254607813 0.37821727847906195 22.212140807013164 -6.794109197268247 1.4796229481577585 1.244681277338289 0.365565205614189 0.8144666277995126 0.1876447842064153 0.22926040319564353 0.9913644677271828 0.09979496586369031 0.23299044747330905 1.60653726091988e-07 6.794109197268247 -0.8791160717241 down AAEK(ub)LYLADPMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAEKLYLADPMK 12 1 P49458;Q6P2S0;Q659G3;E9PE20;P49458-2 P49458 SRP9;DKFZp564M2223 Signal recognition particle 9 kDa protein 1 8854800.0 3491800.0 3954500.0 1408500.0 True False 4782812.822346906 3779777.1142172413 1075841.3089680641 1.0 0.7902833028624608 0.22493903669852447 22.189427901197025 -6.987933620224542 0.5274393473684095 1.008689698677073 5.96621520244212e-11 0.9994631239422358 0.007584466511710607 0.07707924442513925 0.030364874447862965 0.008642571359658555 0.04364267807678052 1.0281734373699629e-07 6.987933620224542 -1.008689698617411 down AAELIANSLATAGDGLIELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAELIANSLATAGDGLIELR 20 0 P35232;C9JW96 P35232 PHB Prohibitin 0 12814500.0 5139700.0 1496500.0 6178300.0 False True 4976543.036829542 2094060.254144402 4560017.88497296 1.0 0.42078612375037083 0.9163023109065801 22.246712489237108 -10.244305616831014 8.01113623021918 1.0000002927217202 0.6685442173284801 0.3736641940612273 0.20229363630369404 1.057582308481761e-06 9.982634823736195e-08 0.1958701433090448 0.06528999037066226 5.697631838294065e-11 10.244305616831014 -0.33145607539324007 AAELIANSLATAGDGLIELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAELIANSLATAGDGLIELR 20 0 P35232;C9JW96 P35232 PHB Prohibitin 0 7696600.0 5139700.0 0.0 2556900.0 False True 4273888.277316385 0.0 3091535.9682301437 1.0 0.0 0.7233544181859963 22.027117764671384 -10.63385647230402 8.94029725437811 1.0003401013649216 0.36167721086333227 0.5093918083571067 0.29530820462391527 0.002002847411471472 8.20252501246453e-05 0.28606923909310733 0.09531031320890296 2.3235045522663513e-11 10.63385647230402 -0.6386628905015893 AAEMHQLK(ub)DSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAEMHQLKDSSR 12 1 Q96BD0;E1P5H9;Q96BD0-3;Q96BD0-4 Q96BD0 SLCO4A1 Solute carrier organic anion transporter family member 4A1 1 23299500.0 1234900.0 3202600.0 18862000.0 True False 1195698.7754500844 4481414.881338367 13921476.352129217 1.0 3.747946366886154 11.642962791267308 20.189422555934108 -6.95241849852386 0.5316309727161873 0.8769235361221532 14.873389351756666 0.9993776607774941 0.11253870133977574 0.08252890639887221 0.03205398777305607 0.12525381798937613 0.6530159073484253 1.1157875249481121e-07 6.95241849852386 13.996465815634513 AAEMHQLK(ub)DSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAEMHQLKDSSR 12 1 Q96BD0;E1P5H9;Q96BD0-3;Q96BD0-4 Q96BD0 SLCO4A1 Solute carrier organic anion transporter family member 4A1 1 40329200.0 2247200.0 19738000.0 18344000.0 True False 3409166.6923260847 16215599.686302098 14718300.359539194 1.0 4.756470172843953 4.317272133589001 21.70098771157492 -10.069691877962303 4.397438463736266 0.9997205381674089 4.536871153559355 0.9885672737111517 0.17930184989506665 5857505.793828891 3353308.866852611 14952.319416368844 0.06137979210435387 8.517421155079494e-11 10.069691877962303 3.5371506153919463 AAEMHQLK(ub)DSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAEMHQLKDSSR 12 1 Q96BD0;E1P5H9;Q96BD0-3;Q96BD0-4 Q96BD0 SLCO4A1 Solute carrier organic anion transporter family member 4A1 1 15506000.0 1234900.0 4248100.0 10023000.0 True False 1026874.0653458375 4225214.642118167 12118762.9588841 1.0 4.114637602319006 11.80160583255422 19.969827831368384 -6.955737358107476 0.4918473142077735 0.8345587776300154 15.408667359190417 0.9995779715780513 0.09325684877778646 0.0812605308472163 0.027036967767500975 0.11111928921260329 0.6340013372932956 1.1072932229863429e-07 6.955737358107476 14.574108581560402 AAEMHQLK(ub)DSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAEMHQLKDSSR 12 1 Q96BD0;E1P5H9;Q96BD0-3;Q96BD0-4 Q96BD0 SLCO4A1 Solute carrier organic anion transporter family member 4A1 1 27946200.0 2247200.0 11514000.0 14185000.0 True False 2909044.698934418 10873235.778380562 11603475.550391046 1.0 3.737734171758661 3.9887580808371195 21.47211403366737 -10.118143072384266 0.5353000979720597 1.1801429112490908e-20 3.972924902611946 0.9994553483405312 0.031590756073042944 1.40960046482012 0.25017574194992637 2.262902619662619 0.04780776049896575 7.618279948551756e-11 10.118143072384266 3.972924902611946 AAENHSFVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAENHSFVTK 10 0 A0A126GW95 A0A126GW95 0 3773500.0 1464600.0 1560400.0 748500.0 False True 1217879.7927812096 1551993.81548485 905007.8893270228 1.0 1.2743407228562693 0.7431011621108375 20.215940312653217 -6.766356099167053 1.588541507854076 1.1580853831781737 0.7405247872184414 0.7163912858412214 0.11551877656011472 0.2723554714533631 1.3558064995388315 0.05734115232990507 0.13694939689739363 1.7125525265587553e-07 6.766356099167053 -0.4175605959597323 AAEQYTPK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAEQYTPKAK 10 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 2115020.0 465490.0 897840.0 751690.0 True False 450713.2747463439 1256352.194173748 554799.8387833737 1.0 2.7874754629332985 1.2309374271161826 18.781850416455217 -6.612671070688419 2.1435195256497224 2.1920616009392355 1.2365993987968886 0.05880830197699183 0.7701152133910107 0.6053809860272475 5.274638673525313 0.29626186599530924 0.8547862263807166 2.439657885754205e-07 6.612671070688419 -0.9554622021423469 AAESYGK(ub)VVDLAPLHLDAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAESYGKVVDLAPLHLDAR 19 1 Q9Y5Q9;A0A494C1S7 Q9Y5Q9 GTF3C3 General transcription factor 3C polypeptide 3 1 6928500.0 1664800.0 2487300.0 2776400.0 True False 2182568.9219461316 2116204.5354194622 2489124.7611093684 1.0 0.9695934520741301 1.1404564300722702 21.05759578184093 -6.860911026642988 1.181198322838053 0.9834626030572926 1.1488726825847073 0.9547343194135139 0.015833668794688994 0.1458615175964898 0.38620308324392594 0.010451554259007114 0.02442137712405488 1.377491644946163e-07 6.860911026642988 0.1654100795274147 AAESYGK(ub)VVDLAPLHLDAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAESYGKVVDLAPLHLDAR 19 1 Q9Y5Q9;A0A494C1S7 Q9Y5Q9 GTF3C3 General transcription factor 3C polypeptide 3 1 9200500.0 1636400.0 2944400.0 4619700.0 True False 1584453.3777200726 4120114.274843156 3409661.981970694 1.0 2.600337966884035 2.1519484447544808 20.595553778604675 -10.562697280674797 5.591883781597022 0.9950646535300544 2.376143205819259 0.9262482523716962 0.18305425587130178 0.011257748261158336 0.000880390519416889 0.17715753452301447 0.05908050703682814 2.7371759744631857e-11 10.562697280674797 1.3810785522892046 AAESYGK(ub)VVDLAPLHLDAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAESYGKVVDLAPLHLDAR 19 1 Q9Y5Q9;A0A494C1S7 Q9Y5Q9 GTF3C3 General transcription factor 3C polypeptide 3 1 24223300.0 1725800.0 6594500.0 15903000.0 True False 2618164.772880183 5417659.951936326 12759765.079467494 1.0 2.06925859214601 4.873553113095617 21.32012446474967 -6.95442718902544 0.5079208481571642 0.9474939871408141 6.117911262950064 0.999504473910949 0.0363600372421697 0.08175521430313452 0.02897079602356889 0.0420315277488981 0.23141474570141277 1.1106387221554915e-07 6.95442718902544 5.17041727580925 AAESYGK(ub)VVDLAPLHLDAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAESYGKVVDLAPLHLDAR 19 1 Q9Y5Q9;A0A494C1S7 Q9Y5Q9 GTF3C3 General transcription factor 3C polypeptide 3 1 6174900.0 1664800.0 2129300.0 2380800.0 True False 2280321.549528356 2035220.4853465105 1818504.0741151308 1.0 0.8925146919597631 0.7974770376095669 21.120805843363822 -6.972576815030263 0.18667733026992256 1.0672759625993595 0.6201284788930338 0.9999961207013277 0.0001628454935942706 0.07547527855371977 0.005932270433110084 0.00345229068894234 0.010457435348269083 1.0651804451911268e-07 6.972576815030263 -0.44714748370632573 AAESYGK(ub)VVDLAPLHLDAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAESYGKVVDLAPLHLDAR 19 1 Q9Y5Q9;A0A494C1S7 Q9Y5Q9 GTF3C3 General transcription factor 3C polypeptide 3 1 9539700.0 1636400.0 4176900.0 3726400.0 True False 1360739.1048116675 4154398.210650264 4505573.011073107 1.0 3.0530453603927636 3.3111218712985386 20.37595905403895 -10.205647635922702 0.457399360699242 1.821736052177332e-23 3.315309143246172 0.999267976158849 0.02797653681026137 1.5398480679698714 0.21132398122015927 2.034465442589669 0.05700430213260734 6.228053923112001e-11 10.205647635922702 3.315309143246172 AAESYGK(ub)VVDLAPLHLDAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAESYGKVVDLAPLHLDAR 19 1 Q9Y5Q9;A0A494C1S7 Q9Y5Q9 GTF3C3 General transcription factor 3C polypeptide 3 1 19957800.0 1725800.0 4317000.0 13915000.0 True False 2234082.1206038673 4076755.155052008 11382612.779957075 1.0 1.8248009405984014 5.094984054068872 21.09125078684212 -6.945077640371681 0.6104991665386612 0.9638536362577231 6.126378326414889 0.9987561722182926 0.06236577045286741 0.08552460941744001 0.04462128450301174 0.06336344312958175 0.27579874345579536 1.1348079238817647e-07 6.945077640371681 5.1625246901571655 AAEVLNK(ub)HSLSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAEVLNKHSLSGR 13 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 9765300.0 2290900.0 4254600.0 3219800.0 True False 3003392.0851071547 3619830.2643009094 2886645.982502501 1.0 1.2052473209377061 0.9611285841820122 21.51816139663862 -6.68374843465224 1.888498274351091 1.129423849540035 0.9620277644383418 0.3413490329555938 0.08691852262724029 0.4302748235434347 2.9699993057244853 0.0368872145167767 0.09682536151928638 2.0713408268157818e-07 6.68374843465224 -0.16739608510169324 AAEVLNK(ub)HSLSGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAEVLNKHSLSGR 13 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 16673800.0 2269100.0 5976200.0 8428500.0 True False 2197068.6625425452 8362527.825471301 6220823.000419948 1.0 3.8062205192048086 2.8314194756302866 21.067148526732936 -10.537945844033416 5.788195060780032 0.9950931604909534 3.318819997416881 0.882968119495666 0.3979608595816919 0.02514465078634135 0.002007220612737256 0.3844845324365545 0.12844131513352278 2.8977049052694797e-11 10.537945844033416 2.3237268369259274 AAEVLNK(ub)HSLSGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAEVLNKHSLSGR 13 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 12768000.0 2154200.0 1934200.0 8679600.0 True False 3268078.8931153626 1589026.898026422 6964073.255596181 1.0 0.48622660284423236 2.1309379251115743 21.64001138063288 -6.822777777016389 1.3599298100124135 0.7238364763609496 2.1689932386471424 0.890629867917091 0.22720787757411934 0.18989642592700415 0.6893284956992148 0.13126819429932474 0.30233369333399224 1.5039113016011645e-07 6.822777777016389 1.4451567622861927 up AAEVLNK(ub)HSLSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAEVLNKHSLSGR 13 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 8721400.0 2290900.0 3533700.0 2896800.0 True False 3137907.6392446593 3377569.4496167647 2212635.5014687143 1.0 1.076376311200095 0.7051308565606247 21.581371458161513 -6.853095944270031 1.2202110638037185 1.0408886900794523 0.6893926526791767 0.944668276692898 0.03765299938627165 0.15408786698682783 0.4399579021604877 0.02412672536957914 0.05594721459842782 1.4025038294045228e-07 6.853095944270031 -0.3514960374002756 AAEVLNK(ub)HSLSGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAEVLNKHSLSGR 13 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 12055600.0 2269100.0 6821800.0 2964700.0 True False 1886857.1881741374 6785049.609378718 3584605.062775987 1.0 3.595952916788808 1.8997755024823666 20.847553802167212 -10.400196585602941 6.218967332614791 0.9996746544243993 2.747864209635566 0.5860638421581776 0.6924615297140211 0.0031241857881622146 0.0003013211367546162 0.6705831023669696 0.22349099770597627 3.979270061000812e-11 10.400196585602941 1.7481895552111668 AAEVLNK(ub)HSLSGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAEVLNKHSLSGR 13 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 11712400.0 2154200.0 3204500.0 6353700.0 True False 2788654.3656303473 3026166.7580181104 5197391.79446736 1.0 1.085170968232944 1.8637633471269366 21.41113770272533 -6.927701670386823 0.765414341690401 0.9870967876182566 2.014639060383124 0.9960672108277057 0.024373967501767308 0.09384829291694284 0.08365345162369975 0.021909748183779058 0.07135981684553705 1.1811317110473186e-07 6.927701670386823 1.0275422727648675 AAEVLNK(ub)HSLSGRPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAEVLNKHSLSGRPLK 16 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 79342300.0 13946000.0 10462000.0 54934300.0 True False 18053371.916758325 9879780.503162878 44936821.07351754 1.0 0.5472540281514844 2.4891095846645817 24.10576498571513 -6.84530763493645 1.2576471016659818 0.7590621081961302 2.559934111515595 0.9331766079389084 0.2144379183722116 0.16269546003945715 0.49758084417170817 0.13357313102445162 0.3082863079643483 1.4278821518487625e-07 6.84530763493645 1.800872003319465 up AAFALGGLGSGFASNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAFALGGLGSGFASNR 16 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 28609600.0 8997300.0 8241300.0 11371000.0 False True 11795547.429977136 7011730.164335785 10194437.998334035 1.0 0.5944387240999274 0.8642615409629866 23.491739039650827 -9.899849199554819 5.2612951578401095 1.0000004407473801 0.7293501325282653 0.572926918484749 0.11015470372364794 5.694332618232192e-07 1.1901830975340236e-07 0.10665700807342272 0.03555227775073283 1.2593626254465618e-10 9.899849199554819 -0.27065030821911484 AAFALGGLGSGFASNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAFALGGLGSGFASNR 16 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 24341900.0 8997300.0 5873300.0 9471300.0 False True 12323844.952890128 5613798.185594169 7234374.007546487 1.0 0.45552327273296706 0.5870224783905543 23.55494910117372 -10.081679794755054 7.59570950838628 1.0000000506750886 0.5212728755618802 0.9464418703558107 0.05368432590706599 4.609689736031252e-08 5.608512450284657e-09 0.05197963046946575 0.017326541682536493 8.285528304182457e-11 10.081679794755054 -0.4787271751132084 AAFGLSEAGFNTACVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAFGLSEAGFNTACVTK 17 0 P31040-2;P31040;D6RFM5;A0A087X1I3;P31040-3;A0A494C1T6 P31040-2 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0 8033700.0 1479800.0 3302600.0 3251300.0 False True 1940032.130403584 2809864.9534339714 2914886.66467184 1.0 1.4483600087847186 1.5024940149137929 20.887649115545884 -11.849294000466083 0.34303646874591814 1.719530395777184e-11 1.5115407377920944 0.9995658021105718 0.004692695859445624 4.867723552298007 0.18018557307034283 3.525260361095147 0.016532518117167303 1.4148356669950166e-12 11.849294000466083 1.511540737774899 AAFGLSEAGFNTACVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAFGLSEAGFNTACVTK 17 0 P31040-2;P31040;D6RFM5;A0A087X1I3;P31040-3;A0A494C1T6 P31040-2 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0 8087600.0 1479800.0 3447200.0 3160600.0 False True 2026922.0500913397 3294891.305634012 2414131.374600257 1.0 1.6255638964929773 1.1910331601017752 20.950859177068775 -10.116727909491031 4.436733522081685 0.9999526102134253 1.4082985282872125 0.5406962472295427 0.1773964303565565 19951559.036593877 45493948.01266516 5478.052519029661 0.0607275175554258 7.643144854587975e-11 10.116727909491031 0.4083459180737872 AAFLNFFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAFLNFFR 8 0 Q5JTZ9 Q5JTZ9 AARS2 Alanine--tRNA ligase, mitochondrial 0 2367410.0 466090.0 943930.0 957390.0 False True 611048.5036219811 803099.3234103227 858328.4667333591 1.0 1.314297177147089 1.4046813986870594 19.220927376833615 -12.694417412009052 0.19293626265633734 3.354601895201061e-07 1.4715847982937629 0.9994441552803836 0.004088975133519329 7.232903855983073 0.12961317026745098 2.836616279793007 0.060556941307200116 2.021075735089708e-13 12.694417412009052 1.4715844628335732 AAFLNFFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAFLNFFR 8 0 Q5JTZ9 Q5JTZ9 AARS2 Alanine--tRNA ligase, mitochondrial 0 3029690.0 466090.0 1228100.0 1335500.0 False True 638416.0686086456 1173838.4812163871 1020082.4054858708 1.0 1.8386731458289156 1.5978332245130094 19.284137438356506 -10.067367735118667 4.351460187594012 0.9999382700638816 1.7182531852387253 0.9222316107255588 0.09832248645053131 68759116.81347056 147855323.92918107 62931.033650273734 0.03598234469057004 8.563124629523212e-11 10.067367735118667 0.7183149151748437 AAFVAYALAFPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAFVAYALAFPR 12 0 Q6XQN6;G5E977;Q6XQN6-3;Q6XQN6-2;C9J8U2 Q6XQN6 NAPRT Nicotinate phosphoribosyltransferase 0 8927800.0 2603200.0 5203200.0 1121400.0 False True 3412820.4094246565 4426902.841914751 1005368.285228369 1.0 1.2971391139392099 0.2945857574140143 21.702533067778123 -6.8272933571989824 1.3398863505551193 1.159091155042058 0.2690535384576671 0.9003764463615322 0.13270790070323943 0.18416655088824532 0.6475665410295859 0.0777855450604479 0.17904543476120857 1.488355383920488e-07 6.8272933571989824 -0.8900376165843908 down AAFVAYALAFPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAFVAYALAFPR 12 0 Q6XQN6;G5E977;Q6XQN6-3;Q6XQN6-2;C9J8U2 Q6XQN6 NAPRT Nicotinate phosphoribosyltransferase 0 14014900.0 2603200.0 4922600.0 6489100.0 False True 3565673.388834824 4705103.255138661 4956508.22720956 1.0 1.3195553103298043 1.3900623211115888 21.765743129301015 -12.58838271474456 0.23417716561327234 6.873353902432814e-23 1.42503163579563 0.9994234738272224 0.004075069482636379 6.935090491203811 0.1448866345938121 3.2941632838379884 0.03563858184190767 2.5799856194150454e-13 12.58838271474456 1.42503163579563 AAFVLPEFAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAFVLPEFAR 10 0 P19623;K7EL89 P19623 SRM Spermidine synthase 0 12201600.0 1860500.0 5424900.0 4916200.0 False True 2439133.5171076274 4615526.06609458 4407518.78352034 1.0 1.8922810226345306 1.8070018523409341 21.21793730211873 -10.155321932702186 4.694765563427695 0.9999117069312503 1.8496414374887775 0.992500941053117 0.03481507557581655 3.351955937731006e-05 6.030835874686546e-06 0.03371316673653262 0.011236517311665016 6.993234111497441e-11 10.155321932702186 0.8497297305575272 AAFVLPEFAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAFVLPEFAR 10 0 P19623;K7EL89 P19623 SRM Spermidine synthase 0 8505000.0 3237900.0 1868400.0 3398700.0 False True 3135114.6368368533 2614461.8635772853 2508478.511185533 1.0 0.8339286330579363 0.8001233772161009 21.580086766090655 -13.999999999640586 0.2237628730512653 2.0189985490588316 0.7826801975296648 0.9995019362346287 0.0019494532592423796 13.104557160767726 0.14982277747952796 5.912443602062536 0.01825485063909439 1.0000000008275809e-14 13.999999999640586 -1.236318351529167 AAFVLPEFAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAFVLPEFAR 10 0 P19623;K7EL89 P19623 SRM Spermidine synthase 0 13849800.0 1860500.0 5709200.0 6280100.0 False True 2548377.1281220005 5456948.666200309 4796869.722719436 1.0 2.1413426631331247 1.8823233303205942 21.281147363641622 -10.176159085262366 4.479939846413987 0.9997973835513616 2.0118329967470174 0.9531541530970662 0.10574419991200493 37081068.21777199 30.897379000369288 78884.15137578738 0.036199052246471145 6.665625577215659e-11 10.176159085262366 1.0120356131956558 AAFVLPEFAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAFVLPEFAR 10 0 P19623;K7EL89 P19623 SRM Spermidine synthase 0 4769590.0 3237900.0 749280.0 782410.0 False True 2692457.313291189 745243.479919565 946008.3135448978 1.0 0.27678933895839525 0.3513549904301072 21.36049204152493 -10.414433333190487 5.978486445731866 1.000216509046023 0.31407216471351734 0.991214836432093 0.030441299740651656 8.787500885587135e-05 8.607021516415537e-06 0.029483700795095588 0.009824887244370858 3.850939243702929e-11 10.414433333190487 -0.6861443443325057 AAGASDVVLYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAGASDVVLYK 11 0 Q9NSD9 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 14139500.0 1701500.0 7153600.0 5284400.0 False True 2230682.9773494373 6086310.764514392 4737620.9795441395 1.0 2.72845170125713 2.12384324785296 21.089054062957967 -10.19288978615086 5.279656586599064 0.9999218627545065 2.426147474555456 0.8812147352774994 0.2468303675037922 0.00022705403888545302 3.4710830069522806e-05 0.23900535045830973 0.07966415855648155 6.413723213274263e-11 10.19288978615086 1.4262256118009495 AAGASDVVLYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAGASDVVLYK 11 0 Q9NSD9 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 6938530.0 2852900.0 629330.0 3456300.0 False True 2762336.2510985043 880624.7509125937 2550991.343222575 1.0 0.31879708727074546 0.9234905208256657 21.397457514649947 -10.591330988482794 9.224516186007378 1.0000643725158422 0.6211438040482434 0.3435649138229824 0.24686506050351975 0.00032687282796156197 1.448128644631531e-05 0.2390662315777173 0.07967535567421816 2.5625303130772805e-11 10.591330988482794 -0.3789205684675988 AAGASDVVLYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAGASDVVLYK 11 0 Q9NSD9 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 13131200.0 1701500.0 5330300.0 6099400.0 False True 2330590.5313085644 5094789.721055049 4658847.341086126 1.0 2.1860509826213277 1.998998656563797 21.15226412448086 -10.33096537765475 6.426822160897167 0.9999452195258798 2.092524819592544 0.978488020206292 0.07636379234027663 5.994764063155493e-05 6.240304891076439e-06 0.07394258254054252 0.02464630799892767 4.666965843011895e-11 10.33096537765475 1.0925796000666643 AAGCNIPVASVAAGFPAGQTHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAGCNIPVASVAAGFPAGQTHLK 23 0 G3V158;Q9Y315;E9PMH9;E9PML7;E9PPM8;E9PPK3 G3V158 DERA Deoxyribose-phosphate aldolase 0 1347600.0 1347600.0 0.0 0.0 False True 1766716.6501769624 0.0 0.0 1.0 0.0 0.0 20.752639245227353 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 AAGDHAK(ub)GLHIPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAGDHAKGLHIPR 13 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34 1 4405920.0 926420.0 1541000.0 1938500.0 True False 897011.3041966697 2156329.3362088366 1430748.696246551 1.0 2.4039043054646516 1.5950174647217816 19.774766640635658 -10.064593278583764 5.264155125709382 0.999988097526451 1.9994608850947968 0.6705770329853988 0.330226669917517 4.613038862831719e-05 8.196642135787627e-06 0.3197444030510637 0.10658019942120983 8.618004597064873e-11 10.064593278583764 0.9994727875683458 AAGDHAK(ub)GLHIPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAGDHAKGLHIPR 13 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34 1 3559970.0 926420.0 1821000.0 812550.0 True False 770359.2773647186 1811189.9115598018 982450.4481932843 1.0 2.351097682312084 1.2753146188543314 19.555171916069934 -6.589266468859616 2.231652056932539 1.9148782108933486 1.2784109411856726 0.0 0.5855878984947533 0.6717649865924971 6.306146090187953 0.21914728076331752 0.6528267034204341 2.574740895630267e-07 6.589266468859616 -0.6364672697076761 AAGEVK(ub)ALDDFYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAGEVKALDDFYK 13 1 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 1 24581300.0 1685700.0 2446600.0 20449000.0 True False 2182171.8801146974 2310444.5592657537 16727491.824458685 1.0 1.0587821153411225 7.6655244148684885 21.05733331022633 -6.9088482482656435 0.9035424127844459 0.7879163581564529 8.49863013622664 0.9904796203171108 0.30524514163566163 0.10518458307968767 0.14293503892893017 0.24849375139740837 0.6806028448948888 1.2335357815866726e-07 6.9088482482656435 7.710713778070186 up AAGFK(ub)DPLLASGTDGVGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAGFKDPLLASGTDGVGTK 19 1 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 7933500.0 2433700.0 3013000.0 2486800.0 True False 3190604.2679843237 2563472.1445820145 2229489.7910700105 1.0 0.8034440906084219 0.698767256548083 21.60539825095273 -13.999999999987992 0.07832737414653332 2.0709490676373083 0.37627153328637647 0.9998934930951383 0.0012886726242793013 12.27526689080834 0.07825738919050083 2.2957197044890973 0.2935039778490608 1.0000000000276499e-14 13.999999999987992 -1.694677534350932 AAGFK(ub)DPLLASGTDGVGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAGFKDPLLASGTDGVGTK 19 1 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 13418700.0 2534400.0 3554500.0 7329800.0 True False 2453946.8592604236 4973830.386472627 5409905.490713431 1.0 2.0268696397002057 2.204573204304791 21.22667257679624 -10.733257923042844 0.3446873307262356 2.870419257408346e-14 2.238155428440929 0.9992436949270378 0.01460126788143061 2.3717083890255526 0.16858477232144636 2.0299035203506084 0.053770173319212584 1.8481706833522574e-11 10.733257923042844 2.2381554284409 AAGFK(ub)DPLLASGTDGVGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAGFKDPLLASGTDGVGTK 19 1 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 8293400.0 2433700.0 2496300.0 3363400.0 True False 3333504.658269559 2386005.211839804 2569034.1913973587 1.0 0.71576477504561 0.7706706468893788 21.668608312475623 -10.668881639127093 6.665787123958369 1.0015936779343144 0.7432177109674953 0.9668467295164693 0.022415228316646572 0.0005338565442896631 2.6518918137345248e-05 0.021825105745721517 0.007234483830984098 2.143474695503139e-11 10.668881639127093 -0.2583759669668191 AAGGIELFVGGIGPDGHIAFNEPGSSLVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAGGIELFVGGIGPDGHIAFNEPGSSLVSR 30 0 D6RAY7;D6R9P4;P46926;D6RB13;D6RFF8 D6RAY7 GNPDA1 Glucosamine-6-phosphate isomerase;Glucosamine-6-phosphate isomerase 1 0 70210000.0 19423000.0 26947000.0 23840000.0 False True 29466111.01150296 22138097.31212801 19128013.550556827 1.0 0.7513070626621123 0.6491529724804759 24.812553327840995 -13.999999999999998 0.12227730417688365 2.183602541013546 0.4910017037125895 0.9996818435339417 0.0026280589052374696 11.955573079973117 0.10790476771980949 3.4287593621033703 0.14037316511527492 1.0000000000000041e-14 13.999999999999998 -1.6926008373009565 AAGGIELFVGGIGPDGHIAFNEPGSSLVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAGGIELFVGGIGPDGHIAFNEPGSSLVSR 30 0 D6RAY7;D6R9P4;P46926;D6RB13;D6RFF8 D6RAY7 GNPDA1 Glucosamine-6-phosphate isomerase;Glucosamine-6-phosphate isomerase 1 0 51173000.0 19423000.0 10624000.0 21126000.0 False True 25143456.38456885 10032765.06075344 17281284.77106529 1.0 0.3990209184967422 0.6873074451956109 24.583679649933444 -10.485509794872724 6.2672691289626465 1.0002724655304704 0.5431641818462036 0.7700193488121655 0.117692481688578 0.000448324667485952 3.6803599405415744e-05 0.11402144798335331 0.037985085129473656 3.2695667272470154e-11 10.485509794872724 -0.4571082836842668 AAGIDEQENWHEGK(ub)ENIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAGIDEQENWHEGKENIR 18 1 P28838-2;P28838 P28838-2 LAP3 Cytosol aminopeptidase 1 22670800.0 5436600.0 6284200.0 10950000.0 True False 8247719.668698817 5162735.411321297 8785727.70044451 1.0 0.6259591279410912 1.0652311248874649 22.975563867179194 -6.681185927676517 1.8978799625948568 0.7635858507224108 1.063565255397065 0.3294262926778282 0.15848759321561667 0.4359188754591701 3.0368181076341263 0.06698543376558623 0.17638827621772749 2.0835986737470958e-07 6.681185927676517 0.2999794046746541 AAGK(ub)ELTVDNSFEFEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAGKELTVDNSFEFEK 16 1 Q9UHA3;H3BMQ2 Q9UHA3 RSL24D1 Probable ribosome biogenesis protein RLP24 1 10582500.0 3536400.0 4282400.0 2763700.0 True False 2940673.2890833416 4259329.861210156 3341576.8920949786 1.0 1.4484199509758742 1.136330548687578 21.48771507799606 -10.192827057299649 8.652232158028989 0.9999999696679543 1.2923752498317262 0.5392140117753668 0.1274099649560857 7.448428355954516e-08 7.011243117035357e-09 0.12336418281005893 0.04112138936798255 6.414649668854435e-11 10.192827057299649 0.2923752801637719 AAGK(ub)GDVPTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAGKGDVPTK 10 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 56903500.0 9560500.0 16937000.0 30406000.0 True False 12533908.084013712 14410065.61990891 27259878.794947185 1.0 1.1496865561259486 2.174890593757873 23.579332982649504 -6.9331035392590445 0.7208645281060404 0.9860625950742972 2.4030184786462034 0.9971138033932706 0.028051933663104024 0.09105799745647768 0.07001892308287704 0.026045940761082416 0.09123190266282942 1.1665314735240999e-07 6.9331035392590445 1.4169558835719063 up AAGK(ub)GDVPTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAGKGDVPTK 10 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 43792500.0 8292500.0 14595000.0 20905000.0 True False 8029259.126585 20422859.611919556 15429353.363442965 1.0 2.5435546779526836 1.9216409783508093 22.936835443279374 -10.384576256876183 5.595614436754776 0.9995562476695732 2.2325978281516834 0.8396785061457079 0.25389520467854454 0.0014060260596606535 0.0001546394446669972 0.24591334570981757 0.08194432495015722 4.1249980076454974e-11 10.384576256876183 1.2330415804821102 AAGK(ub)GDVPTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAGKGDVPTK 10 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 5401000.0 1542700.0 803400.0 3054900.0 True False 2340388.6864771475 660026.99300715 2451097.6759897647 1.0 0.28201597316753857 1.0473036765868413 21.158316718571278 -11.897254989171277 14.292876754995682 0.9356059741630901 0.6981938424235511 0.0 0.35877971510804674 0.0 0.0 0.0 0.1041048285334088 1.2669078024656758e-12 11.897254989171277 -0.237412131739539 AAGK(ub)GDVPTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAGKGDVPTK 10 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 46815500.0 9560500.0 10530000.0 26725000.0 True False 13095275.212797865 10064749.781946536 20413105.4186521 1.0 0.7685787139555776 1.5588145408889613 23.642543044172395 -6.8283023771194085 1.3353973584925412 0.8761875613221363 1.5793626337700997 0.902446451250691 0.10360581828932315 0.18291970493988816 0.6385417190505951 0.06092500372292916 0.14022445470763498 1.484901421090792e-07 6.8283023771194085 0.7031750724479634 AAGK(ub)GDVPTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAGKGDVPTK 10 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 30747900.0 8292500.0 12802000.0 9653400.0 True False 6895581.170038344 12733033.085001944 11671881.30772143 1.0 1.8465496628953668 1.6926609983849303 22.71724071871365 -10.061541328978175 4.484591282775238 0.9999532096631414 1.769605330682897 0.9708856903341202 0.06282478438858748 9312961.006153181 6964794.150500675 3861.697044031598 0.021506595098687013 8.678779830655214e-11 10.061541328978175 0.7696521210197556 AAGK(ub)GDVPTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAGKGDVPTK 10 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 3422110.0 1542700.0 884300.0 995110.0 True False 1997055.56116328 835087.9276378267 814010.1906908439 1.0 0.41815958648210566 0.4076051796058618 20.929443040663728 AAGK(ub)GDVPTK(ub)RPPVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAGKGDVPTKRPPVLR 16 3 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 2 7126340.0 815740.0 1039200.0 5271400.0 True False 789844.7802135008 1454157.9793564063 3890662.201389776 1.0 1.841068037397597 4.925856698499801 19.591209638082816 -6.946869070973431 0.5922204227936699 0.9645723784436534 5.958167822246386 0.9989321155886011 0.055152243062236046 0.0847678656360133 0.04135713290299486 0.05704830498374316 0.2586020465512489 1.1301365714973882e-07 6.946869070973431 4.993595443802732 AAGK(ub)GDVPTK(ub)RPPVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAGKGDVPTKRPPVLR 16 3 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 2 5252340.0 815740.0 1721300.0 2715300.0 True False 678323.9534093561 1712027.0152487026 3283056.6758712986 1.0 2.523907650089316 4.839953917844376 19.371614913517092 -6.965038272274938 0.3573947101058926 0.7943915125382467 6.648518116379291 0.9999139324701469 0.014646323177313897 0.07794796990501526 0.01481414889368867 0.031243211595264817 0.19813236020360384 1.0838313969867e-07 6.965038272274938 5.854126603841045 AAGK(ub)LDQPDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAGKLDQPDR 10 1 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 10948600.0 2413900.0 3662400.0 4872300.0 True False 3164646.27624085 3115984.195923388 4368161.134401806 1.0 0.9846232166031316 1.3802999618619496 21.59361282283814 -6.89785908017336 0.9747208299662653 0.9825688832530376 1.420070923063749 0.9854701622863621 0.02205964169758301 0.11299788146899668 0.18644868762070402 0.01704023033924132 0.043877387668252193 1.2651467955722265e-07 6.89785908017336 0.43750203981071134 AAGK(ub)LDQPDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAGKLDQPDR 10 1 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 7974900.0 1700200.0 2598700.0 3676000.0 True False 1646228.0816424296 3636374.4620414698 2713145.3223638525 1.0 2.2089129098159264 1.6480980689243057 20.65073280147413 -10.21039163840061 5.234560207670031 0.9999316885321179 1.9285054893703746 0.7851699699837735 0.22895170006178686 0.00018255313393868893 2.7537103208671025e-05 0.2216976896379673 0.07389384345195121 6.160392189973246e-11 10.21039163840061 0.9285738008382567 AAGK(ub)LDQPDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAGKLDQPDR 10 1 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 10143100.0 2355100.0 1725700.0 6062300.0 True False 3572858.8808727097 1417735.352044358 4864083.747799513 1.0 0.39680698267547043 1.3613982275760659 21.768647501471328 -6.737642547858722 1.6954329590317219 0.6401205128718355 1.3616650857783534 0.5942480212497889 0.25345405547432587 0.32210805269812076 1.8170927720267411 0.11831047487753395 0.29106614782949497 1.8296054789466065e-07 6.737642547858722 0.721544572906518 AAGK(ub)LDQPDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAGKLDQPDR 10 1 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 10875200.0 2413900.0 3297200.0 5164100.0 True False 3306384.0631946772 3151518.8016176773 3944445.9379779715 1.0 0.9531617444867047 1.1929787534019232 21.65682288436103 -6.856014440224954 1.2055441744710302 0.9748070487282349 1.2037470404110822 0.94862186197242 0.023525274290702326 0.15097179467707567 0.41919040497204435 0.015241720941151274 0.0354377068763296 1.3931104814652446e-07 6.856014440224954 0.2289399916828473 AAGK(ub)LDQPDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAGKLDQPDR 10 1 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 7274400.0 1700200.0 2624300.0 2949900.0 True False 1413791.6316308975 2610162.3750172365 3566710.451203453 1.0 1.846214333583408 2.5227978235300688 20.431138076908407 -6.973656435258656 0.14651860427878421 0.17405143788903682 4.212703249788362 0.9999986874980089 0.0007136720913811179 0.07513304450634613 0.004463737525181992 0.035760537029690564 0.08563279291141773 1.0625357831091816e-07 6.973656435258656 4.038651811899325 AAGK(ub)LDQPDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAGKLDQPDR 10 1 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 9561930.0 2355100.0 844630.0 6362200.0 True False 3048723.3759613927 797625.5980105588 5204344.881684727 1.0 0.26162609710664003 1.7070570989549272 21.539773823563777 -6.767850709928885 1.5826368335011296 0.5753136629543324 1.7145377895486105 0.7222391957519221 0.31102206144204414 0.2699455954317743 1.3340529570988617 0.1549310870937884 0.36953886203236497 1.7066689609122092e-07 6.767850709928885 1.1392241265942782 AAGPSLSHTSGGTQSK(ub)VVPIASLTPYQSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAGPSLSHTSGGTQSKVVPIASLTPYQSK 29 1 P27694 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 12537500.0 5481900.0 3884200.0 3171400.0 True False 5307880.0851403475 5435181.315835406 2340715.200039369 1.0 1.0239834413462814 0.44098871159359987 22.339704347242616 -6.897306091230173 0.9781496518846724 1.0260627294913067 0.3830357201993489 0.9851774782550671 0.03279293655928164 0.11341519340108096 0.1888175897319831 0.025266405755682796 0.0648933064546064 1.2667587381993417e-07 6.897306091230173 -0.6430270092919579 down AAGVNVEPFWPGLFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAGVNVEPFWPGLFAK 16 0 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 0 214285000.0 58600000.0 77811000.0 77874000.0 False True 76825167.4832073 66201902.10490248 69816345.50015517 1.0 0.8617215461244926 0.9087691935772981 26.195075671189933 -10.134544956485946 6.70803427521439 1.0000001795841813 0.8852453706902663 0.8880477080045969 0.01920712164295462 5.158482390070337e-08 6.651199885598821e-09 0.018597244660444358 0.006199071854311918 7.33592771799843e-11 10.134544956485946 -0.11475480889391498 AAGVNVEPFWPGLFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAGVNVEPFWPGLFAK 16 0 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 0 344125000.0 145200000.0 78315000.0 120610000.0 False True 140590705.4784617 109586587.90732987 89018622.77755816 1.0 0.7794724945321394 0.6331757314582626 27.066925979374467 -8.389923232171052 0.0800393478856655 1.6180605016619798 1.718840086501715e-07 0.9999924774455908 0.00041349167423600924 0.10819051425155686 0.017933165356895226 0.17916016642737606 0.17190527944846068 4.074522945231565e-09 8.389923232171052 -1.6180603297779712 AAGVNVEPFWPGLFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAGVNVEPFWPGLFAK 16 0 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 0 285507000.0 37072000.0 184900000.0 63535000.0 False True 56240934.32623372 151903150.36970624 50977279.401620254 1.0 2.700935754170973 0.9064088285930516 25.745117226200705 -6.658308796337021 1.9790735760344522 2.0964171912287606 0.9139460110415656 0.22833376063988342 0.7245188451604335 0.48848908935355706 3.67626071424535 0.29596740165412116 0.8029300618045324 2.1962976842730114e-07 6.658308796337021 -1.182471180187195 AAGVNVEPFWPGLFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAGVNVEPFWPGLFAK 16 0 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 0 368760000.0 58600000.0 123130000.0 187030000.0 False True 80266003.60545523 117689709.46354002 142857366.00376055 1.0 1.466246034149647 1.779799162618971 26.258285732712825 -8.122167036245468 0.09607523802956672 1.8994702085742535e-11 2.8907925407240995 0.9999893680636056 0.0010446345280927718 0.09295487043186101 0.017840304779443632 0.24750852838609208 0.26523984782507404 7.54801863583622e-09 8.122167036245468 2.890792540705105 AAGVNVEPFWPGLFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAGVNVEPFWPGLFAK 16 0 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 0 267891000.0 145200000.0 53729000.0 68962000.0 False True 120740233.45065649 53439551.212628536 83381635.35573845 1.0 0.44259936961665675 0.690586997993626 26.847331254808743 -10.366519921609322 5.914216831378243 1.000077688582109 0.5665931838051455 0.8028618623747679 0.10124052534108723 0.0001037260566221853 1.111019446635626e-05 0.09804317737720891 0.03267523905060982 4.300115080339607e-11 10.366519921609322 -0.43348450477696354 AAGVNVEPFWPGLFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAGVNVEPFWPGLFAK 16 0 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 0 148987000.0 37072000.0 63680000.0 48235000.0 False True 47990434.79836979 60136152.02078107 39456724.9328947 1.0 1.2530862092298416 0.8221789425053307 25.516243548293154 -6.747539824131708 1.6590442262170673 1.1492564057613035 0.8214853815756625 0.6382861233412251 0.10633785613389289 0.3043518782366265 1.6474215797769851 0.050650873109188525 0.12328137855290873 1.7883815297707548e-07 6.747539824131708 -0.32777102418564097 AAGVNVEPFWPGLFAK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAGVNVEPFWPGLFAK 16 0 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 1 21622900.0 9232800.0 8857200.0 3532900.0 True False 8939709.817779198 12393926.149687823 2607527.5052718334 1.0 1.3863902075477792 0.29167921089407295 23.0917965717344 -6.811311007544874 1.4090303489630063 1.2102531338528169 0.27195019881319754 0.8632231507222182 0.1676491658164738 0.20501579115246485 0.80197515138701 0.09354998777771233 0.21627312237994256 1.5441482459954032e-07 6.811311007544874 -0.9383029350396193 down AAGVNVEPFWPGLFAK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAGVNVEPFWPGLFAK 16 0 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 1 20758700.0 9232800.0 9123000.0 2402900.0 True False 7677482.282391322 9073852.588226283 2905335.2802456976 1.0 1.1818786751273402 0.37842292217452916 22.872201847168675 -6.847220240947929 1.2484157971257812 1.0968734099660915 0.34798291555374655 0.9361651307385279 0.08691170422277152 0.16054023181366292 0.4828855598734097 0.05451245981142215 0.1259424375502071 1.4216076735988908e-07 6.847220240947929 -0.7488904944123449 down AAGVVLEMIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAGVVLEMIR 10 0 Q9Y230;Q9Y230-2;M0R0Y3;X6R2L4;M0QXI6 Q9Y230 RUVBL2 RuvB-like 2 0 9711100.0 2041600.0 4007300.0 3662200.0 False True 2676557.3708825214 3409426.460333061 3283270.674302953 1.0 1.2738103421294855 1.2266767415564062 21.351947145870465 -10.139488345694472 4.788693152825687 0.9999810488568975 1.2502435418446334 0.9740825340438546 0.01924221186317338 3.893524061290579e-06 6.996370756278504e-07 0.0186326016903113 0.006210397173363808 7.252899410075563e-11 10.139488345694472 0.25026249298773584 AAGVVLEMIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAGVVLEMIR 10 0 Q9Y230;Q9Y230-2;M0R0Y3;X6R2L4;M0QXI6 Q9Y230 RUVBL2 RuvB-like 2 0 10196600.0 2041600.0 3645900.0 4509100.0 False True 2796434.6921654795 3484812.0826209765 3444143.4478295343 1.0 1.2461625127109395 1.2316194822924642 21.415157207393356 -10.041143355415224 4.539916998495144 0.9999896468410965 1.2388909975078604 0.9972281707223899 0.00593716736092438 697356.3264483243 1542375.0679996863 41.15387287017697 0.002032450398132926 9.096129707073756e-11 10.041143355415224 0.23890135066676388 AAGVVLEMIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAGVVLEMIR 10 0 Q9Y230;Q9Y230-2;M0R0Y3;X6R2L4;M0QXI6 Q9Y230 RUVBL2 RuvB-like 2 0 6600100.0 2719000.0 2003600.0 1877500.0 False True 2260968.9721235214 1992806.209116538 2270076.569420825 1.0 0.8813947620187275 1.0040281832301086 21.10850976306303 -11.04551414363216 8.939672030773172 1.146200607661767 0.9427114726233946 0.22539193578740302 0.05006488456328117 0.0529811447828816 0.0002697407028208027 0.0176049664402034 0.016158372011948734 9.005044356202772e-12 11.04551414363216 -0.2034891350383724 AAGYDLYSAYDYTIPPMEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAGYDLYSAYDYTIPPMEK 19 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 4911200.0 1462800.0 2118300.0 1330100.0 False True 1917744.9657753522 1802257.8970687268 1192474.01122013 1.0 0.9397797565538474 0.6218105287727911 20.870979443446966 -6.93859727174676 0.6724900225859155 1.003670518235157 0.5394915332178004 0.9979742841701837 0.007467614339130862 0.0884125671833761 0.057568568113165526 0.0071940875935391285 0.027540441988709436 1.1518680395895662e-07 6.93859727174676 -0.46417898501735666 AAGYDLYSAYDYTIPPMEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAGYDLYSAYDYTIPPMEK 19 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 19090000.0 6582000.0 2534300.0 9973700.0 False True 6373058.0128046395 3546259.2061999054 7361288.765413585 1.0 0.5564454613585538 1.1550638250308423 22.60355436272834 -6.708273410768742 1.8015371171640842 0.7268253875355314 1.153574688241026 0.4567731112542224 0.18696364542641278 0.3785794186904508 2.3940796540463727 0.0826241131532249 0.21033076182160307 1.9576118678833323e-07 6.708273410768742 0.42674930070549466 AAGYDLYSAYDYTIPPMEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAGYDLYSAYDYTIPPMEK 19 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 4245800.0 1462800.0 0.0 2783000.0 False True 2003636.6906836163 0.0 2125712.717684145 1.0 0.0 1.0609272267612937 20.934189504969858 -10.543855763318879 5.045853007269163 1.002344404169269 0.5304636133806392 0.2070789676876168 0.4331217266318934 0.011471433355133308 0.0010370144448596057 0.4211477838398605 0.13978943617715633 2.8585397560520838e-11 10.543855763318879 -0.4718807907886299 AAHFVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAHFVFR 7 0 A0A0D9SF98;A0A087WWJ5;A0A0D9SF30;A0A087WTF6;A0A087WX77;A0A087WWD4;A0A087WV75;P13591-1;P13591;A0A087WTR3;A0A087WZS4;A0A087WVU1;H7BYX6;A0A087WTE4;P13591-4;P13591-3 A0A0D9SF98 NCAM1 Neural cell adhesion molecule 1 0 3056560.0 1082500.0 582860.0 1391200.0 False True 1419167.9829449109 495899.5599704853 1247251.9693327164 1.0 0.34942978275302244 0.8788614063463777 20.436613936607046 -10.177973859346217 7.595668277107953 1.0000002200825375 0.6141455945497647 0.4145940345529676 0.21613955524949466 8.056609979893382e-07 8.703829373359007e-08 0.209276342982832 0.0697587414948309 6.637830230163576e-11 10.177973859346217 -0.38585462553277283 AAHFVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAHFVFR 7 0 A0A0D9SF98;A0A087WWJ5;A0A0D9SF30;A0A087WTF6;A0A087WX77;A0A087WWD4;A0A087WV75;P13591-1;P13591;A0A087WTR3;A0A087WZS4;A0A087WVU1;H7BYX6;A0A087WTE4;P13591-4;P13591-3 A0A0D9SF98 NCAM1 Neural cell adhesion molecule 1 0 2383040.0 1082500.0 611250.0 689290.0 False True 1482729.5034625453 584242.9538665551 526493.8983731604 1.0 0.39403205541010766 0.35508425315855996 20.499823998129937 -13.925718475901816 0.3906308414383383 9.999999999848272 0.3522526905590389 0.9998227206059932 0.0039313342686238505 23.92697200149434 0.20472594072595357 181.45082950706268 0.01023637859726671 1.1865376520150919e-14 13.925718475901816 -9.647747309289233 AAHGIPDLAQK(ub)LHFYDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAHGIPDLAQKLHFYDR 17 1 Q8N6F8;B4DWM3 Q8N6F8 WBSCR27 Williams-Beuren syndrome chromosomal region 27 protein 1 83701000.0 7917700.0 9847300.0 65936000.0 True False 7666356.947429854 13779378.242991112 48665383.56240016 1.0 1.79738281656852 6.347915169631546 22.87010974125575 -6.936904129361384 0.6877600254250504 0.9451670436202197 7.470812425331346 0.997729661512486 0.11224394748616272 0.08920777402790024 0.0612563478858685 0.10685024524873496 0.3972906457336475 1.1563674824914e-07 6.936904129361384 6.525645381711126 AAHLCAEAALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAHLCAEAALR 11 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 124582700.0 48923800.0 42061600.0 33597300.0 False True 64139575.57875311 35786173.2348327 30120973.68405839 1.0 0.5579421583620088 0.4696160430166032 25.93471147149197 -13.999999999999998 0.22639571129911304 3.7448350558895496 0.4251713883524163 0.9995050888196592 0.005161781948210738 13.181557057577509 0.1506827433507837 16.2314948623125 0.04689959971210704 1.0000000000000041e-14 13.999999999999998 -3.3196636675371334 AAHLCAEAALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAHLCAEAALR 11 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 38590300.0 17167500.0 7472800.0 13950000.0 False True 16622527.109514408 10456728.010137184 10296076.508970559 1.0 0.6290696920657725 0.6194050062987888 23.986636394768198 AAHLCAEAALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAHLCAEAALR 11 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 259204400.0 48798400.0 128958000.0 81448000.0 False True 74030740.44090639 105944437.34654711 65349767.10007348 1.0 1.4310870959222028 0.8827382613069724 26.14162112242129 -6.6970982805715815 1.8414651731534302 1.2684546702964778 0.8844705941583278 0.40365424593878707 0.182067016447768 0.40161752232142034 2.645677701577107 0.07894277758155789 0.20373166823531383 2.008638207593128e-07 6.6970982805715815 -0.38398407613815 AAHLCAEAALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAHLCAEAALR 11 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 99420600.0 48923800.0 22646100.0 27850700.0 False True 67012250.97598234 21645520.421361774 21272938.263171326 1.0 0.3230084067631108 0.3174484956608262 25.99792153301486 AAHLCAEAALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAHLCAEAALR 11 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 33405700.0 17167500.0 7515200.0 8723000.0 False True 14275536.899202108 7474714.125949603 10546938.969404986 1.0 0.5236030125330965 0.7388120701782136 23.767041670202474 -10.320520424968494 5.782992820366025 1.0000433866908907 0.6312075413556537 0.7965598356352565 0.08785872987596371 4.915261493246125e-05 5.775270125205369e-06 0.08507882805535921 0.028356283135711122 4.7805688249624594e-11 10.320520424968494 -0.36883584533523694 AAHLCAEAALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAHLCAEAALR 11 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 187628400.0 48798400.0 97291000.0 41539000.0 False True 63170490.760271005 91876670.32433748 33979328.22613277 1.0 1.454423880811771 0.5378987533131997 25.91274744451374 -6.771910208870922 1.5673469175583097 1.2600094053394049 0.5323922850106902 0.7377480180903739 0.19161663935390838 0.2633483269003363 1.277041202482691 0.09635368949760863 0.2289429785785372 1.6907904693380036e-07 6.771910208870922 -0.7276171203287146 AAHSEGNTTAGLDMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAHSEGNTTAGLDMR 15 0 P78371;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 0 19109900.0 2812000.0 10098000.0 6199900.0 False True 3686559.231446739 8591417.761695698 5558393.82164024 1.0 2.3304705613868886 1.5077456980011483 21.813843506065496 -10.052158180326021 4.867314283858872 0.99998014338716 1.9191081297053514 0.6246296914195626 0.3358760190410415 232691275.49097955 3.666803411665838 58372.499924576434 0.11497929508980545 8.86832947665059e-11 10.052158180326021 0.9191279863181914 AAHSEGNTTAGLDMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAHSEGNTTAGLDMR 15 0 P78371;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 0 17874500.0 2812000.0 7416300.0 7646200.0 False True 3851672.3914426635 7088623.343575511 5840325.038432098 1.0 1.840401421295447 1.5163088769978628 21.877053567588387 -10.369314038525967 5.469743878833093 0.9997591390202669 1.6783551491466635 0.8538305011868907 0.1323102271616029 0.00038875743876150905 4.482537139519209e-05 0.1281531203073533 0.042702942194146255 4.2725382699926075e-11 10.369314038525967 0.6785960101263966 AAIAQLNGK(ub)EVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAIAQLNGKEVK 12 1 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 1 11681150.0 2191500.0 4398250.0 5091400.0 True False 2121932.032066453 6154494.161570755 3757809.601274025 1.0 2.9004200269210196 1.7709377795736774 21.016947015128647 -10.590133754151058 6.16042327326341 0.9960121468228037 2.335678903245387 0.6509102696554656 0.46110919658884 0.02525049514190012 0.0016799675221076343 0.44636558675791865 0.14882235326430404 2.5696042733585926e-11 10.590133754151058 1.3396667564225835 AAIAQLNGK(ub)EVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAIAQLNGKEVK 12 1 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 1 35591700.0 5267600.0 4063600.0 26260500.0 True False 7991334.313143853 3338418.8309482876 21070100.664613992 1.0 0.41775487047981197 2.6366185969668 22.930004979390752 -6.836982714994289 1.29644546719442 0.6900509855223962 2.705295167323523 0.9191224724646798 0.26713276571291983 0.17235322689084875 0.5640353979649881 0.16165137658797696 0.3721439627719397 1.4555170092921262e-07 6.836982714994289 2.015244181801127 up AAIAQLNGK(ub)EVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAIAQLNGKEVK 12 1 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 1 6563700.0 1632000.0 2819500.0 2112200.0 True False 2235394.503141686 2694925.1671603266 1613341.862124491 1.0 1.2055702755700632 0.7217257892765931 21.092098030487346 -6.79124776747389 1.49119699838106 1.1147048600912324 0.7163901092162298 0.8054037058221991 0.08746325873436335 0.2334853953195724 1.02563101348314 0.04616231296215537 0.10798673837661603 1.6171571770452706e-07 6.79124776747389 -0.39831475087500257 AAIAQLNGK(ub)EVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAIAQLNGKEVK 12 1 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 1 5533400.0 2191500.0 1147300.0 2194600.0 True False 1822329.3499112518 1141119.2671787802 2653480.713316079 1.0 0.6261871748014995 1.4560928371401716 20.797352290562923 -6.7842399559788005 1.5191325269502005 0.7894996162870238 1.463586893952617 0.7821539220966215 0.15839384249938987 0.24405413471598264 1.1126359263453869 0.08209680149107315 0.19305685551615936 1.643463427444993e-07 6.7842399559788005 0.6740872776655933 AAIAQLNGK(ub)EVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAIAQLNGKEVK 12 1 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 1 26304800.0 5267600.0 4032400.0 17004800.0 True False 6819012.039919423 3807993.395235515 13910100.883982327 1.0 0.5584376993240376 2.0398997395151537 22.7011313014832 -6.826831411846812 1.342046640097515 0.7634963322797572 2.0772361892489504 0.8993838392065762 0.19699086429949722 0.18475101720864376 0.6518890670618948 0.11528634149186416 0.26536155195005384 1.4899393428861853e-07 6.826831411846812 1.3137398569691932 up AAIDWFDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAIDWFDGK 9 0 Q92804-2;Q92804;A0A075B7D9;H3BPE7;P35637-2;P35637 Q92804-2;H3BPE7 TAF15;FUS TATA-binding protein-associated factor 2N;RNA-binding protein FUS 0 17968700.0 1308800.0 7760600.0 8899300.0 False True 1715849.4744372284 6602748.730581869 7978485.804113453 1.0 3.848093220850545 4.649875133557546 20.710491565047345 -9.492821503146784 0.37908850485809603 3.37463840527493e-23 4.791699195212208 0.9983354808609545 0.06389753393064457 0.8422222577264943 0.15513902578180372 1.3462380145719903 0.21449783559441646 3.2149816380678444e-10 9.492821503146784 4.791699195212208 AAIDWFDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAIDWFDGK 9 0 Q92804-2;Q92804;A0A075B7D9;H3BPE7;P35637-2;P35637 Q92804-2;H3BPE7 TAF15;FUS TATA-binding protein-associated factor 2N;RNA-binding protein FUS 0 19183300.0 7096800.0 2036500.0 10050000.0 False True 6871515.968591915 2849685.0702072023 7417603.506462651 1.0 0.4147098083206738 1.0794711880706926 22.71219698555811 -6.674189084308464 1.9224896039698294 0.6277807656854648 1.0768467905359969 0.29788461392926746 0.24837793803424976 0.4514860311812655 3.2209063063417984 0.10386358876827233 0.27599393803454697 2.117439038183827e-07 6.674189084308464 0.44906602485053204 AAIDWFDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAIDWFDGK 9 0 Q92804-2;Q92804;A0A075B7D9;H3BPE7;P35637-2;P35637 Q92804-2;H3BPE7 TAF15;FUS TATA-binding protein-associated factor 2N;RNA-binding protein FUS 0 19490400.0 1308800.0 9658100.0 8523500.0 False True 1792698.7289900968 9231373.206934275 6510424.846992743 1.0 5.149428098347958 3.631633548744881 20.773701626570237 -9.606180173220764 9.327588342734868 0.9999985835994166 4.3905308235464195 0.8693402991023229 0.6196370301513661 0.0 0.0 0.5999609746171715 0.1999869915390571 2.4763944771498383e-10 9.606180173220764 3.390532239947003 AAIGLLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAIGLLAR 8 0 P07741-2;P07741;H3BQB1;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 0 63503000.0 14840000.0 22236000.0 26427000.0 False True 19455383.71076443 18918475.47524911 23692587.545684062 1.0 0.972403102221096 1.21779081296532 24.213666098501125 -6.87896470089037 1.0856070167726461 0.983121095646039 1.2348362656363365 0.9728385006630067 0.018087951114569862 0.12854877172668935 0.27788900789566956 0.01284697063342202 0.030985916818535554 1.3214030324080446e-07 6.87896470089037 0.2517151699902975 AAIGLLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAIGLLAR 8 0 P07741-2;P07741;H3BQB1;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 0 32333900.0 10971000.0 4052900.0 17310000.0 False True 10622731.610221772 5671244.105594287 12775991.711131198 1.0 0.5338781316979812 1.2027030503940666 23.340651463666514 -6.719313895450575 1.761663185187047 0.7162023686842591 1.2016254836428324 0.5092391448840918 0.19616391166911895 0.3566999817212092 2.163051087085962 0.08842458719527671 0.22216824423396736 1.9084733707763572e-07 6.719313895450575 0.48542311495857327 AAIGLLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAIGLLAR 8 0 P07741-2;P07741;H3BQB1;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 0 48535600.0 9686200.0 29539000.0 9310400.0 False True 14694673.556073727 24267534.66073962 7470195.359106715 1.0 1.6514510899569563 0.5083607560658652 23.80878997391431 -6.752124834957003 1.642047720610903 1.382078202566338 0.5057234585469398 0.6580491718301646 0.27377699431646696 0.2963469943305983 1.5727635857304485 0.1316755230443551 0.3189542862404831 1.769600225810821e-07 6.752124834957003 -0.8763547440193983 AAIGLLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAIGLLAR 8 0 P07741-2;P07741;H3BQB1;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 0 56017000.0 14840000.0 14312000.0 26865000.0 False True 20326749.03592073 13679648.516545003 20520040.302042607 1.0 0.6729875245850085 1.0095092070935838 24.276876160024017 -10.949693880601838 10.960931295950832 1.0445980924654052 0.8412483658424177 0.22882439572873847 0.13738440158814874 0.08482786820031596 0.00038932421279662345 0.07536307760503787 0.04434062494829763 1.122809605715223e-11 10.949693880601838 -0.20334972662298756 AAIGLLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAIGLLAR 8 0 P07741-2;P07741;H3BQB1;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 0 27981600.0 10971000.0 10519000.0 6491600.0 False True 9122872.597707648 10462332.05914198 7848963.546232866 1.0 1.1468243085813679 0.8603609731659649 23.12105673910079 -6.767389488186245 1.5844062276656021 1.084496937539026 0.8589056390426949 0.7204539077465996 0.061839456606159734 0.2706915497197497 1.3406584179426404 0.030771456146682936 0.07342685482511165 1.7084824100628334e-07 6.767389488186245 -0.2255912984963312 AAIGLLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAIGLLAR 8 0 P07741-2;P07741;H3BQB1;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 0 39804200.0 9686200.0 18148000.0 11970000.0 False True 12538976.84354687 17138047.846625894 9791582.82257177 1.0 1.366781999876323 0.7808916903464069 23.579916296006758 -6.737486435685192 1.6962290735840473 1.2188736560509197 0.7807561629652428 0.5934412344347223 0.1541177788447599 0.32239420948202596 1.820394565896083 0.07191252150325732 0.17693363035818782 1.8302632700110705e-07 6.737486435685192 -0.43811749308567693 AAIISAEGDSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAIISAEGDSK 11 0 P35232;C9JW96 P35232 PHB Prohibitin 0 16871000.0 2264600.0 7141400.0 7465000.0 False True 2968912.5304175983 6075930.956959179 6692593.409336353 1.0 2.0465173341110714 2.254223841480097 21.501503158845555 -10.650400584917634 0.3262044520472238 3.3373729550140026e-15 2.303392070851194 0.9991665157394419 0.015846218969457565 2.260891521708263 0.15928969929248368 1.8788075201651364 0.06714991931076172 2.2366571370837134e-11 10.650400584917634 2.3033920708511904 AAIISAEGDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAIISAEGDSK 11 0 P35232;C9JW96 P35232 PHB Prohibitin 0 16600700.0 2264600.0 6811300.0 7524800.0 False True 3101883.8185138893 6510354.244042967 5747597.218120608 1.0 2.0988388427655793 1.8529376193316867 21.564713220368446 -10.158611587937134 4.630720802593994 0.9998760731996476 1.9758882310603985 0.9545452769334736 0.10038875413008001 70284766.1770586 22.388370842874576 92873.31074930093 0.03436574071703037 6.94046250058577e-11 10.158611587937134 0.9760121578607509 AAIK(ub)SLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAIKSLSR 8 1 Q16401 Q16401 PSMD5 26S proteasome non-ATPase regulatory subunit 5 1 9513900.0 3282100.0 3105800.0 3126000.0 True False 4302864.883901616 2642426.746313581 2802551.5067093647 1.0 0.6141086967893736 0.6513222195738937 22.036866107638375 -9.784717616013346 6.337482390172237 1.0000000072975055 0.6327154586309631 0.99235941540739 0.015192357059651686 1.5681249640501173e-09 3.112839038548725e-10 0.014709936689288041 0.00490331215669769 1.6416568531343455e-10 9.784717616013346 -0.36728454866654237 AAIK(ub)SLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAIKSLSR 8 1 Q16401 Q16401 PSMD5 26S proteasome non-ATPase regulatory subunit 5 1 9788100.0 3282100.0 3147400.0 3358600.0 True False 4495581.065417484 3008337.4609400327 2565367.852538259 1.0 0.6691765574158681 0.5706421072622844 22.100076169161266 -13.999999999999998 0.16974677335081356 2.6672487867239885 0.4834887268236434 0.9995141628689119 0.004047659732829282 12.089073935340096 0.1304634257481955 6.636580703589158 0.08051953334827892 1.0000000000000041e-14 13.999999999999998 -2.183760059900345 AAILPTSIFLTNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAILPTSIFLTNK 13 0 O14744-2;O14744;O14744-3;O14744-5;H0YJX6 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 58043000.0 16866000.0 23489000.0 17688000.0 False True 22111489.330576327 19984532.759404864 15857815.435276804 1.0 0.903807629627632 0.7171753651776055 24.398292866094458 -6.960634377336338 0.42640151412473354 1.007702559304269 0.6061657626130044 0.9997930001409212 0.0016892823156724628 0.07947531603558153 0.0202999454338706 0.00242574568129853 0.015509638708229115 1.0948777310822273e-07 6.960634377336338 -0.40153679669126463 AAILPTSIFLTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAILPTSIFLTNK 13 0 O14744-2;O14744;O14744-3;O14744-5;H0YJX6 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 50394000.0 16866000.0 14216000.0 19312000.0 False True 23101815.986512054 13587890.113974549 14750903.343124775 1.0 0.5881741124553935 0.6385170478258964 24.46150292761735 -10.60316933775891 6.84601816690242 1.0007423574240115 0.6133455801406449 0.987445325223861 0.020552417301940525 0.00023328634981069715 1.3522473080799556e-05 0.019935264252762843 0.006633264161226736 2.4936222376456734e-11 10.60316933775891 -0.38739677728336663 AAILPTSIFLTNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAILPTSIFLTNK 13 0 O14744-2;O14744;O14744-3;O14744-5;H0YJX6 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 31754300.0 13681000.0 10441000.0 7632300.0 False True 11376357.671063565 10384752.26062377 9228178.642231988 1.0 0.9128363014673843 0.8111716341078483 23.439535393120984 -6.969100614413014 0.2788317115905541 1.0227145905407657 0.6982003410400841 0.9999744873643805 0.0003897158499422503 0.07659562445671501 0.010070396190014938 0.0018905963568440665 0.0093453785043529 1.0737406265458769e-07 6.969100614413014 -0.32451424950068164 AAILPTSIFLTNK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAILPTSIFLTNKK 14 1 O14744-2;O14744;O14744-3;O14744-5;H0YJX6 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 1 22220100.0 4128600.0 3993500.0 14098000.0 True False 5344554.086872832 3771258.214431364 11532308.657695657 1.0 0.7056263540665142 2.1577681636754398 22.34963815366031 -6.853938985190389 1.2159932022728217 0.842218119471486 2.220362198305176 0.9458343115323696 0.14587627023982533 0.15317902790712384 0.4338895394721487 0.09377010840179259 0.21759994458075096 1.3997839669154482e-07 6.853938985190389 1.37814407883369 up AAILPTSIFLTNKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAILPTSIFLTNKK 14 1 O14744-2;O14744;O14744-3;O14744-5;H0YJX6 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 15775400.0 4742800.0 5337500.0 5695100.0 False True 6217856.729340532 4541165.805412048 5105825.683256726 1.0 0.7303426249729117 0.8211552477823418 22.56798594408433 -10.689729765047625 9.586607662790074 1.0002378458070178 0.7757489363776268 0.8904765364898044 0.037074098014489465 0.0001886607427280427 6.10597136400148e-06 0.035933924914709106 0.01196561368214825 2.0430087889346534e-11 10.689729765047625 -0.22448890942939104 AAILPTSIFLTNKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAILPTSIFLTNKK 14 1 O14744-2;O14744;O14744-3;O14744-5;H0YJX6 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 13862400.0 4851100.0 2046900.0 6964400.0 False True 4697104.48585789 2864237.844442487 5140214.712478459 1.0 0.6097879774797805 1.0943368894506587 22.16334025564979 -6.692341548056575 1.8578667157426394 0.7559053193904401 1.0927221662771716 0.3815214412396789 0.1649539138917191 0.41164946304562977 2.756559925664806 0.07097687248449651 0.18430064079816427 2.0307593053841387e-07 6.692341548056575 0.3368168468867314 AAILPTSIFLTNKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAILPTSIFLTNKK 14 1 O14744-2;O14744;O14744-3;O14744-5;H0YJX6 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 16280900.0 3043800.0 6537200.0 6699900.0 False True 4617667.131586922 5370585.584623275 5375661.828329514 1.0 1.1630516950617882 1.1641510042067706 22.138732748300818 AAILPTSIFLTNKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAILPTSIFLTNKK 14 1 O14744-2;O14744;O14744-3;O14744-5;H0YJX6 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 15666800.0 4742800.0 4094900.0 6829100.0 False True 6496341.329350728 3913973.777976533 5216207.229729361 1.0 0.6024889363945586 0.80294537575517 22.631196005607222 -10.140310810138237 5.258810037572855 1.000008958342252 0.7027171560746716 0.7457090042196242 0.08183599868211656 8.595587241094422e-06 1.4052677597766989e-06 0.07923975212487355 0.026412455001243635 7.239176907922957e-11 10.140310810138237 -0.29729180226758045 AAILPTSIFLTNKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAILPTSIFLTNKK 14 1 O14744-2;O14744;O14744-3;O14744-5;H0YJX6 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 10742400.0 4851100.0 2638300.0 3253000.0 False True 4033904.590168593 2624086.9542384525 3933187.2598274006 1.0 0.6505079373056717 0.9750322973461841 21.943745531084065 -10.4741320631897 8.608751367788782 1.0000055629971039 0.8127701178947575 0.30738680594823786 0.13248651520041838 1.4146027941926218e-05 8.641320081499646e-07 0.128283325877322 0.04275983891402301 3.356355364100955e-11 10.4741320631897 -0.18723544510234635 AAILPTSIFLTNKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAILPTSIFLTNKK 14 1 O14744-2;O14744;O14744-3;O14744-5;H0YJX6 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 17117200.0 3043800.0 9609900.0 4463500.0 False True 3940259.102267968 9075100.617218988 3651188.799377537 1.0 2.3031735684578365 0.9266367273350005 21.909859070393267 -6.65855371527065 1.9776386224243194 1.839854765393884 0.9323588564435052 0.22945119624464705 0.5550593269886869 0.4880053543773236 3.667372853984021 0.2268546205595235 0.6153604354233744 2.1950594386585207e-07 6.65855371527065 -0.9074959089503787 AAIVEK(ub)LSSLPFQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAIVEKLSSLPFQK 14 1 P61970;H3BRV9 P61970 NUTF2 Nuclear transport factor 2 1 55968500.0 7275900.0 14147600.0 34545000.0 True False 9538775.359915834 12036833.226912862 30970614.77903874 1.0 1.2618845473072415 3.246812469154532 23.185372626374036 -6.931115854633794 0.7375796494440204 0.9710299993700594 3.666128060129456 0.9967529563822974 0.05716201415026243 0.09206266600741897 0.07487317198668154 0.05242719195501973 0.17851262679273835 1.1718827063775521e-07 6.931115854633794 2.695098060759397 up AAIVEK(ub)LSSLPFQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAIVEKLSSLPFQK 14 1 P61970;H3BRV9 P61970 NUTF2 Nuclear transport factor 2 1 116868400.0 22888600.0 31173800.0 62806000.0 True False 22162013.92158622 43621660.9092194 46355224.46038735 1.0 1.968307621480694 2.091652167731764 24.401585653119714 -10.889225135182237 0.38541261347236205 2.921636893631665e-15 2.1045363641928727 0.9994333309401149 0.011620111982837054 2.6041350574273974 0.18849486679147734 2.3888581235100017 0.03280251088084776 1.2905500881564784e-11 10.889225135182237 2.1045363641928696 AAIVEK(ub)LSSLPFQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAIVEKLSSLPFQK 14 1 P61970;H3BRV9 P61970 NUTF2 Nuclear transport factor 2 1 157626000.0 30776000.0 86805000.0 40045000.0 True False 46689442.02697912 71313969.53943944 32130088.197653 1.0 1.527411047196307 0.6881660350339353 25.4765930116325 -6.7367850284848325 1.6981608678019355 1.3149569678990034 0.6879783581980233 0.5906100324435906 0.2216184625822586 0.323636911983129 1.831174063189539 0.10329008179607198 0.2543945725791738 1.8332216245746228e-07 6.7367850284848325 -0.6269786097009801 AAIVEK(ub)LSSLPFQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAIVEKLSSLPFQK 14 1 P61970;H3BRV9 P61970 NUTF2 Nuclear transport factor 2 1 64406300.0 7275900.0 11618400.0 45512000.0 True False 9965996.853804292 11105060.671089055 34763002.9490625 1.0 1.1142950207585056 3.4881611402267816 23.248582687896928 -6.916930231731945 0.8471786155383313 0.9416062350976304 3.8451895802559193 0.993284912871689 0.09398675560509863 0.10001191153289368 0.11522125075277666 0.07968940459402152 0.23213193717982183 1.2107926285837302e-07 6.916930231731945 2.903583345158289 up AAIVEK(ub)LSSLPFQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAIVEKLSSLPFQK 14 1 P61970;H3BRV9 P61970 NUTF2 Nuclear transport factor 2 1 71683100.0 22888600.0 23413900.0 25380600.0 True False 19032885.036905624 23287764.673404716 30687566.11336465 1.0 1.223554107968849 1.6123444267046259 24.18199092855399 -6.962683086390768 0.39580785473654434 0.977614012195918 1.8723850802639375 0.9998571334655683 0.003024072261657671 0.07875622235545962 0.017689186109750166 0.00500710001116335 0.03262667305218492 1.0897249979965114e-07 6.962683086390768 0.8947710680680194 AAIVEK(ub)LSSLPFQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAIVEKLSSLPFQK 14 1 P61970;H3BRV9 P61970 NUTF2 Nuclear transport factor 2 1 117851600.0 30776000.0 63903000.0 23172600.0 True False 39840138.685655735 60346741.87474835 18955424.570954617 1.0 1.5147221838481182 0.47578711310509153 25.247719333724948 -6.77199643938943 1.566848309646638 1.2944763869088016 0.4695020354670547 0.7381323388297982 0.2170499830614327 0.263209781526172 1.2755414352257168 0.10917291190573368 0.25939990284057457 1.690454790964009e-07 6.77199643938943 -0.8249743514417469 down AAK(ub)EFGVSPDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAKEFGVSPDK 11 1 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 1 11489560.0 4651800.0 4072500.0 2765260.0 True False 6098554.848095281 3464898.8744806647 2479137.4214469404 1.0 0.5681508096238296 0.40651227761298764 22.54003598241054 -13.999999999999607 0.1364078945817964 3.0572769135621036 0.19754699088787628 0.9996176353806215 0.00489872715075705 11.932030873527221 0.11543948016451816 6.548503933902719 0.18639767343231062 1.0000000000009039e-14 13.999999999999607 -2.8597299226742274 AAK(ub)EFGVSPDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAKEFGVSPDK 11 1 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 1 17459300.0 4588100.0 5721100.0 7150100.0 True False 4442453.276898963 8005565.065142358 5277274.311597865 1.0 1.8020594851884655 1.1879189228708433 22.08292517224315 -10.509390517658018 5.605492152526173 0.9991199891035002 1.4949892040296502 0.4641382632212542 0.2507218346706865 0.002761918474058058 0.00024173086049774948 0.24316039254199573 0.08092012418417793 3.094635351206384e-11 10.509390517658018 0.49586921492615 AAK(ub)EFGVSPDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAKEFGVSPDK 11 1 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 1 43847400.0 12875600.0 19642900.0 11328900.0 True False 19533226.532446444 16137471.024321806 9089737.94936674 1.0 0.8261549108395388 0.46534749055758245 24.21942694000491 -6.9593144172906065 0.444995637521211 1.0122491899012882 0.2650686520143667 0.9997439061594213 0.0035634483217431056 0.07994701028478915 0.022043589710464283 0.004788177466100229 0.029868399417625355 1.0982104772994574e-07 6.9593144172906065 -0.7471805378869215 down AAK(ub)EFGVSPDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAKEFGVSPDK 11 1 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 1 12835500.0 4651800.0 4728800.0 3454900.0 True False 6371696.170168199 4519865.97994955 2638923.775899011 1.0 0.709366212581074 0.41416346690450395 22.60324604393343 -6.970930947132154 0.23489029026017053 1.1129485057420765 0.002096301205955362 0.9999887601702842 0.0008018143713799921 0.07600177332095662 0.007941192561081925 0.007319151440926312 0.029048199261299857 1.0692248725738976e-07 6.970930947132154 -1.110852204536121 down AAK(ub)EFGVSPDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAKEFGVSPDK 11 1 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 1 14944200.0 4588100.0 9132300.0 1223800.0 True False 3815208.437293088 9083102.487280365 1479690.921788124 1.0 2.3807617949505473 0.3878401261971346 21.863330447677427 -6.720355912611981 1.7581806992962086 1.8397250271082477 0.39091539882055265 0.5141368992516377 0.5810041182228401 0.3546234020142053 2.1425787810128423 0.2623768541759731 0.6583521229374764 1.903899796248598e-07 6.720355912611981 -1.448809628287695 AAK(ub)EFGVSPDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAKEFGVSPDK 11 1 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 1 34649700.0 12875600.0 16797900.0 4976200.0 True False 16667718.016019901 15863082.09845915 4070582.6601237883 1.0 0.9517248901866837 0.24421955400321838 23.99055326209736 -6.9207130441583065 0.8194382366832277 1.0152137935098138 0.12824232927365714 0.9943762129059969 0.02590688507758453 0.09775447873274794 0.10345969687124286 0.02240594181301336 0.06757904447812979 1.2002921225059205e-07 6.9207130441583065 -0.8869714642361566 down AAK(ub)ETISLAEQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAKETISLAEQR 12 1 O60239 O60239 SH3BP5 SH3 domain-binding protein 5 1 9210200.0 1148900.0 6332500.0 1728800.0 True False 1742965.295840796 5202415.898951679 1387101.9222400435 1.0 2.984807506704868 0.7958287669582738 20.73311241359166 -6.6679400297850195 1.9444278762097187 2.269101744995655 0.8047003859576917 0.2700799936786852 0.8434995706329447 0.46585139328765557 3.3935219735470334 0.3494630757873723 0.9362773125457784 2.1481270810510187e-07 6.6679400297850195 -1.4644013590379634 AAK(ub)LAPEFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAKLAPEFAK 10 1 P30041 P30041 PRDX6 Peroxiredoxin-6 1 4173540.0 1561900.0 895740.0 1715900.0 True False 2021910.3396518626 845891.2815812575 1403623.8066207962 1.0 0.4183624095452744 0.6942067504647489 20.947287592575186 -10.456195586489976 6.182210889337018 1.0001928372611932 0.5562845800050252 0.7752811100063266 0.1126129806145066 0.0002994403990256057 2.633967427838864e-05 0.10908360917227919 0.03634568320723022 3.497876031174356e-11 10.456195586489976 -0.443908257256168 AAK(ub)VLEQLTGQTPVFSK(ub)AR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAKVLEQLTGQTPVFSKAR 19 2 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 2 26089100.0 7943900.0 9605300.0 8539900.0 True False 7691725.242771025 13440746.380977772 6303043.998491586 1.0 1.7474293421505007 0.8194577678675439 22.874875798204354 -6.692364006952458 1.858235838886246 1.4675630148708811 0.82259362497109 0.38136680699366776 0.31596217154841244 0.41163344320153855 2.7576775407024505 0.13593876036624694 0.352914110625119 2.0306542903898617e-07 6.692364006952458 -0.6449693898997911 AAK(ub)VLEQLTGQTPVFSK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAKVLEQLTGQTPVFSKAR 19 2 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 2 29854300.0 7943900.0 17839000.0 4071400.0 True False 6605704.824439881 17742897.76623575 4922710.91597333 1.0 2.685996156018102 0.7452211454802239 22.65528107363863 -6.677010680087453 1.9123548822998166 2.069593094097636 0.7527470271823551 0.3105452822166689 0.715036266512885 0.4452099687180876 3.14522226194806 0.30030122656210684 0.7951151003570055 2.1037267046825953e-07 6.677010680087453 -1.316846066915281 AALCAVHVIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AALCAVHVIR 10 0 O43747;O43747-2;H3BR36;H3BUN9;H3BNR4 O43747 AP1G1 AP-1 complex subunit gamma-1 0 11003030.0 5093630.0 2920200.0 2989200.0 False True 6677798.256783086 2484517.542850445 2679906.258431107 1.0 0.3720563945349434 0.40131584623853334 22.67094107806886 -10.711386532656173 6.780030449909214 1.0067744596914405 0.3866861203868542 0.998295929939333 0.011945121137900567 0.0012230183362350636 5.206159371763736e-05 0.01156406222753733 0.0038552712696265914 1.9436294340888545e-11 10.711386532656173 -0.6200883393045864 AALCAVHVIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AALCAVHVIR 10 0 O43747;O43747-2;H3BR36;H3BUN9;H3BNR4 O43747 AP1G1 AP-1 complex subunit gamma-1 0 10569500.0 2521600.0 4691400.0 3356500.0 False True 3825451.5536531885 3854183.015924497 2693086.303793788 1.0 1.0075106067527821 0.7039917421570725 21.867198621904897 -6.901225564276086 0.9534728921564554 1.0121983634523761 0.6713256678635886 0.9871666480463975 0.01601197193348134 0.11050925981901205 0.17236947518817167 0.012565277896039378 0.032898917945221186 1.2553777750539675e-07 6.901225564276086 -0.3408726955887875 AALCAVHVIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AALCAVHVIR 10 0 O43747;O43747-2;H3BR36;H3BUN9;H3BNR4 O43747 AP1G1 AP-1 complex subunit gamma-1 0 11733930.0 5093630.0 1598100.0 5042200.0 False True 6976882.661174992 1527490.6577900066 3851336.207368668 1.0 0.21893598215291735 0.5520138999614559 22.734151139591752 -10.569742878625158 6.392193179920947 1.001092076244712 0.3854749410701246 0.8194504364528745 0.13597849053659894 0.002119499740692971 0.0001426628568109036 0.13186038142431422 0.04388686910755587 2.6931287823466446e-11 10.569742878625158 -0.6156171351745874 AALCAVHVIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AALCAVHVIR 10 0 O43747;O43747-2;H3BR36;H3BUN9;H3BNR4 O43747 AP1G1 AP-1 complex subunit gamma-1 0 8549600.0 2521600.0 3505000.0 2523000.0 False True 3264260.9081670614 3309943.668857378 2063839.8881661335 1.0 1.0139948251611934 0.6322533480710693 21.638324943997347 -6.89839052390851 0.9714019871455823 1.0165799029890366 0.5934696073540416 0.9857479644111865 0.021100558654018383 0.11259918086533366 0.18418342099063298 0.016339742106202426 0.042179418605213966 1.2635995893419519e-07 6.89839052390851 -0.4231102956349949 AALCHFCIDMLNAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AALCHFCIDMLNAK 14 0 P54920;M0R0Y2;M0R2M1;M0R0I4 P54920 NAPA Alpha-soluble NSF attachment protein 0 12293200.0 3880000.0 4975800.0 3437400.0 False True 5086717.57397345 4233430.035516485 3081730.8218690874 1.0 0.8322518350885311 0.6058387903501821 22.27830356406745 -6.966952142023507 0.3227977174813701 1.0300066550251024 0.4007509435238787 0.999947913630235 0.0011656079021489087 0.07730463252578813 0.012556534004270453 0.0033939338148529993 0.01986720509365464 1.0790656255413037e-07 6.966952142023507 -0.6292557115012236 AALCHFCIDMLNAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AALCHFCIDMLNAK 14 0 P54920;M0R0Y2;M0R2M1;M0R0I4 P54920 NAPA Alpha-soluble NSF attachment protein 0 13352900.0 3880000.0 3953800.0 5519100.0 False True 5314540.853057442 3779108.0425318344 4215602.249432473 1.0 0.7110883417817219 0.793220405297524 22.34151362559034 -10.063375133190876 6.952458085931623 1.0000000762669066 0.752154373539623 0.9239057411416244 0.0335302745225961 3.9611990770270336e-08 5.357910621421822e-09 0.03246555838038481 0.010821849568314737 8.642211027534185e-11 10.063375133190876 -0.24784570272728357 AALCHLLQYFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AALCHLLQYFLK 12 0 Q13535;Q13535-2;Q13535-3 Q13535 ATR Serine/threonine-protein kinase ATR 0 19174400.0 7229300.0 4036200.0 7908900.0 False True 10967376.632624136 3315908.575025466 6345702.4484059885 1.0 0.3023429108071104 0.5785980240278908 23.386715142394312 -10.383880322677177 5.916840159319616 1.0001265730846673 0.4404704674179041 0.8454335100732501 0.11278067770428633 0.0001883495735711773 1.961272015576604e-05 0.10922379532414575 0.03639980721022364 4.1316134002610204e-11 10.383880322677177 -0.5596561056667633 AALCHLLQYFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AALCHLLQYFLK 12 0 Q13535;Q13535-2;Q13535-3 Q13535 ATR Serine/threonine-protein kinase ATR 0 13797700.0 7229300.0 2606100.0 3962300.0 False True 9358471.360807488 2461068.2440539845 3241202.0566312606 1.0 0.26297758994708653 0.3463388337335892 23.15784146448676 -10.592033068961154 6.4889997356696965 1.0015663940414252 0.3046582118619498 0.9893355951867253 0.03403208526678104 0.0007725165139600108 4.856843126365506e-05 0.033007512355161125 0.01098380828957948 2.5583910731107606e-11 10.592033068961154 -0.6969081821794754 AALEGVSK(ub)DLQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AALEGVSKDLQAR 13 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 26779400.0 6186200.0 10722000.0 9871200.0 True False 8110168.107246008 9122319.394028667 8849822.915236568 1.0 1.1248002844575262 1.0912009218809802 22.9513003882028 -10.027859680848566 4.119293777812503 0.9999894975362236 1.108000603205326 0.9323235277321158 0.013716882528421683 3159979.0008849707 0.034852599701959974 320.3457191709165 0.004695653708536208 9.378649791393632e-11 10.027859680848566 0.10801110566910244 AALEGVSK(ub)DLQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AALEGVSKDLQAR 13 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 46819100.0 15203100.0 12978600.0 18637400.0 True False 14720485.912256204 18161022.662504904 13755705.82998476 1.0 1.2337244008626187 0.9344600383423367 23.811321958679294 -6.6983282793890995 1.836716660678033 1.145371383708304 0.9353750746881466 0.40965714822876986 0.09868869921867661 0.39903332541032827 2.6159011596070556 0.042883468621643155 0.1105178036181469 2.0029574370484338e-07 6.6983282793890995 -0.2099963090201573 AALEGVSK(ub)DLQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AALEGVSKDLQAR 13 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 42882900.0 16305900.0 9360200.0 17216800.0 True False 24737242.420968223 7689799.178423609 13813891.933608487 1.0 0.31085919147986535 0.5584248922547369 24.560181349354906 -10.2503399960188 5.541930246672601 1.0000396059157237 0.43464204186749955 0.8742695304070649 0.10106827411890755 4.9461415837864725e-05 6.690848939754413e-06 0.09786576399839053 0.03261964520769328 5.6190125744983135e-11 10.2503399960188 -0.5653975640482242 AALEGVSK(ub)DLQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AALEGVSKDLQAR 13 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 33332600.0 6186200.0 13071000.0 14075400.0 True False 8473405.315769047 12493479.999983225 10751080.411962423 1.0 1.4744343666333064 1.2688028025703684 23.01451044972569 -10.104028264582553 4.36482389150147 0.9999579098690626 1.371618584600085 0.8132467000305941 0.08394873461850014 27557780.366926678 1.1262278767955936 12640.410355571123 0.030292390311605345 7.869945691575345e-11 10.104028264582553 0.3716606747310224 AALEGVSK(ub)DLQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AALEGVSKDLQAR 13 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 44117200.0 15203100.0 21916900.0 6997200.0 True False 12642051.26152669 21798829.309535984 8460282.168602604 1.0 1.7243110994080477 0.669217518073955 23.59172723411357 -6.721971515103828 1.7525132350367498 1.439733247875852 0.6707079878993362 0.521715470367002 0.30472033392878434 0.3514797412033541 2.1107955490182464 0.1380130593728083 0.34562541107782496 1.8968303281408353e-07 6.721971515103828 -0.7690252599765158 AALEGVSK(ub)DLQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AALEGVSKDLQAR 13 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 34211900.0 16305900.0 15733100.0 2172900.0 True False 21108308.987341866 14857539.1544936 1777454.4958367771 1.0 0.703871596886482 0.08420638985826259 24.331307671447355 -7.352665144526451 0.6185121262315919 0.9996107103187231 1.2930739436441576e-20 0.9954171928902141 0.02583086788199059 0.10506121309544657 0.08123174511321342 0.024187874146937013 0.06449287245466394 4.439508128281793e-08 7.352665144526451 -0.9996107103187231 down AALHLYSNTLNFQISEVEPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AALHLYSNTLNFQISEVEPK 20 0 P41227;F8W808;A8MWP7;C9JW55 P41227;C9JW55 NAA10 N-alpha-acetyltransferase 10 0 22420400.0 10554000.0 3248300.0 8618100.0 False True 10218969.04696752 4545363.129660721 6360761.072541875 1.0 0.44479664325919044 0.6224464565170037 23.284746319797108 -10.69860748550721 7.612303055584762 1.0023683578081517 0.5336215498880987 0.9018585940593912 0.07252523256372678 0.0029248658727268045 0.00011580345637160221 0.07045734669325154 0.02340741815826114 2.0016701578711274e-11 10.69860748550721 -0.46874680792005297 AALHLYSNTLNFQISEVEPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AALHLYSNTLNFQISEVEPK 20 0 P41227;F8W808;A8MWP7;C9JW55 P41227;C9JW55 NAA10 N-alpha-acetyltransferase 10 0 180426000.0 47691000.0 64849000.0 67886000.0 False True 72350733.679122 53276189.28245045 54468302.344509244 1.0 0.7363600418861291 0.7528369039915759 26.10850431082153 -10.092430535584413 4.798198107137355 1.0000112856186743 0.7445984729360915 0.9968882114395339 0.00672665079626941 8.121314465987346e-07 1.5361563965001727e-07 0.006513339384994506 0.0021710172077903044 8.08294203594961e-11 10.092430535584413 -0.25541281268258276 AALHLYSNTLNFQISEVEPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AALHLYSNTLNFQISEVEPK 20 0 P41227;F8W808;A8MWP7;C9JW55 P41227;C9JW55 NAA10 N-alpha-acetyltransferase 10 0 141584000.0 47691000.0 52596000.0 41297000.0 False True 61736939.630153544 49668986.36440017 33781369.74300303 1.0 0.804526214968726 0.5471824477432234 25.87963063291398 -6.967334672752358 0.3154224470478181 1.0371909323165969 0.30627275824830574 0.9999534990977758 0.0012645059793328648 0.07717738702051703 0.012111424780277947 0.003975825242042027 0.0227303622217433 1.0781155926895076e-07 6.967334672752358 -0.7309181740682911 AALIYTCTVCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AALIYTCTVCR 11 0 E5RHV4;H0YAP1;E5RHR6;Q9Y5V0 E5RHV4 ZNF706 Zinc finger protein 706 0 36961600.0 13632000.0 15490000.0 7839600.0 False True 17871684.012475777 13178952.379547086 7028433.394753279 1.0 0.7374208479932381 0.3932720268468772 24.091172247218797 -6.967402549416673 0.3140957331535428 1.050518842077832 0.06916926220009666 0.9999544502938792 0.0016767293574627472 0.07715485298617088 0.012032620152880981 0.0053473318405226795 0.030435031341873017 1.077947105234809e-07 6.967402549416673 -0.9813495798777353 down AALK(ub)NGETAEQLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AALKNGETAEQLQK 14 1 Q9UKK3 Q9UKK3 PARP4 Poly [ADP-ribose] polymerase 4 1 11502000.0 1394600.0 2208700.0 7898700.0 True False 2115710.158916852 1814540.228348135 6337518.482876806 1.0 0.8576506667043172 2.9954568475113477 21.01271056873532 -6.8909802356148555 1.0166078926499882 0.8878131325000681 3.1828684469528703 0.981516247970646 0.13268540882810273 0.1183509816443116 0.2172535151124713 0.09932071462617015 0.24848808776952636 1.285345153614772e-07 6.8909802356148555 2.295055314452802 up AALLELWELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AALLELWELR 10 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 2242100.0 491030.0 1061600.0 689470.0 False True 643745.0851412847 903213.4180843881 618130.2582632453 1.0 1.4030606818320905 0.960209673876706 19.29612998698801 -6.667187314696566 1.9477351496774975 1.2578952444330616 0.9620343320853154 0.26652660610235124 0.17132375334518649 0.46757895331650384 3.4171580349485042 0.0708884557441218 0.19006648303742713 2.1518534228881947e-07 6.667187314696566 -0.29586091234774614 AALLELWELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AALLELWELR 10 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 3873730.0 1672100.0 943430.0 1258200.0 False True 1619020.100761265 1320146.5189224565 928639.6748090852 1.0 0.8153984736210022 0.5735813127782897 20.626689466693236 -6.967410999432625 0.3139354215534473 1.0355643096111802 0.3456848129266412 0.999954563567449 0.001176946531808986 0.07715211049248455 0.012023122205511818 0.003759929681740013 0.021388459893716395 1.077926131950548e-07 6.967410999432625 -0.689879496684539 AALLELWELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AALLELWELR 10 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 4815830.0 491030.0 1988500.0 2336300.0 False True 672577.0605868036 1900641.4949098467 1784514.057608866 1.0 2.8259088902788227 2.653248470966182 19.3593400485109 -10.281884248832636 7.519697240578704 0.9999930748601101 2.739578680622502 0.9926656490150908 0.0704883210151593 8.183770240201087e-06 7.815894798872337e-07 0.06825029389957524 0.022750007782819506 5.22535440198731e-11 10.281884248832636 1.7395856057623922 AALLK(ub)ASPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AALLKASPK 9 1 P50914 P50914 RPL14 60S ribosomal protein L14 1 2334170.0 475450.0 790120.0 1068600.0 True False 460357.0999981718 1105619.0364213674 788701.6026871639 1.0 2.4016552290075643 1.7132387068436568 18.812393871539456 -10.31258220450356 7.032751029461611 0.9999845182382273 2.0574469679256104 0.7588014076865548 0.2810448683004933 6.822266225573579e-05 6.668290336289878e-06 0.2721244923890403 0.09070684120540565 4.8687535928078056e-11 10.31258220450356 1.057462449687383 AALLK(ub)ASPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AALLKASPK 9 1 P50914 P50914 RPL14 60S ribosomal protein L14 1 2318120.0 475450.0 1375100.0 467570.0 True False 395357.7410062987 1367692.0633640194 565336.7252005823 1.0 3.459378485628867 1.4299371596004125 18.592799146973732 -6.598731804028532 2.195380319009713 2.655321136029701 1.4364077897430254 0.016949055072268626 1.0633575559118653 0.6443037903254475 5.866821644177972 0.40233167265809355 1.183196632393606 2.519232184325393e-07 6.598731804028532 -1.2189133462866757 AALLNQHYQVNFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AALLNQHYQVNFK 13 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 190161000.0 51835000.0 65606300.0 72719700.0 False True 67956186.97085398 55818095.77135438 65195363.02061842 1.0 0.8213835746154273 0.9593734717426146 26.018101569226772 -10.544646333981614 4.831783876397038 1.0006913932688033 0.8903785231790143 0.45695376187458603 0.056334139603481354 0.00042219352156472155 3.978798036267181e-05 0.05488616229123395 0.018181765375597327 2.853340928713001e-11 10.544646333981614 -0.11031287008978896 AALLNQHYQVNFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AALLNQHYQVNFK 13 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 160571260.0 54165100.0 21336560.0 85069600.0 False True 52445658.5489767 29856359.676690504 62787319.72670401 1.0 0.56928181479138 1.1971881269842324 25.644320015677643 -6.7220881461666835 1.7518433367325215 0.7385428388999401 1.1963237831821296 0.5223448695979236 0.181202703127261 0.3512708643117184 2.1079390080750353 0.08209462130415249 0.20558053640745452 1.8963209971610307e-07 6.7220881461666835 0.4577809442821895 AALLNQHYQVNFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AALLNQHYQVNFK 13 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 177114400.0 38151100.0 78858400.0 60104900.0 False True 57878007.91901095 64785502.396508574 48225140.17008644 1.0 1.119345753695658 0.8332204563358189 25.78651193136759 -6.7933934689842745 1.4825643628091008 1.0664089452945817 0.829878350708736 0.8121899296241534 0.050853434812178834 0.23032652834028516 0.9999855804443382 0.02699287443026635 0.06304935628008997 1.6091870578012e-07 6.7933934689842745 -0.2365305945858458 AALLNQHYQVNFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AALLNQHYQVNFK 13 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 162018200.0 51835000.0 52209800.0 57973400.0 False True 70999800.28820416 49902998.40127949 44281276.91965145 1.0 0.702861109449773 0.6236817109330418 26.081311630749664 -13.999999999999998 0.18562632247259606 2.5695212744154436 0.5643083589578244 0.9994924188792017 0.0036496325182428352 12.282801424134666 0.13661834124985023 6.963297345822232 0.05640849332130264 1.0000000000000041e-14 13.999999999999998 -2.0052129154576193 AALLNQHYQVNFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AALLNQHYQVNFK 13 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 107932600.0 54165100.0 27058500.0 26709000.0 False True 45040680.570786126 26912730.489808246 32293728.411537014 1.0 0.5975205114299302 0.7169902408731159 25.42472529111192 -10.532090219788369 9.290874640759839 1.0000154056327348 0.6572553761515242 0.916485598690529 0.048773312807360795 1.5564662815865577e-05 7.839146550363514e-07 0.047226674347264644 0.015741519020189446 2.9370394517081935e-11 10.532090219788369 -0.34276002948121065 AALLNQHYQVNFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AALLNQHYQVNFK 13 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 186088700.0 38151100.0 94200000.0 53737600.0 False True 49387351.020610824 88957687.19154494 43957908.19433863 1.0 1.8012241060351712 0.8900641011499821 25.557638253460038 -6.6744969314095535 1.9212820503382724 1.5094408778381994 0.8936600080549529 0.2990564857266931 0.33999695850412776 0.45095090884311634 3.213297341096174 0.1422449735406108 0.3778491052923642 2.1159386357558963e-07 6.6744969314095535 -0.6157808697832464 AALLNQHYQVNFKGK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 AALLNQHYQVNFKGK 15 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 6012100.0 2214300.0 1396300.0 2401500.0 True False 2144008.2585465414 1953849.8716083053 1772475.1065442837 1.0 0.911307064149488 0.8267109510790195 21.031879032275267 -6.97169978623545 0.21372251641890483 1.0422407190773395 0.693405728230227 0.9999927728567387 0.00019011619367415367 0.07575493633813599 0.0070216894241622975 0.002459975812108813 0.008692267250074945 1.0673336796151569e-07 6.97169978623545 -0.34883499084711256 AALLNQHYQVNFKGK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AALLNQHYQVNFKGK 15 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 6201900.0 2214300.0 2774200.0 1213400.0 True False 1841288.560122512 2759254.833964413 1467116.329872291 1.0 1.4985455803737917 0.796787837412445 20.812284307709543 -6.715934070992687 1.7743300770265475 1.3046218917887027 0.7981502408126635 0.49313409738268976 0.20990067664025486 0.3632549388566561 2.2327909612077095 0.09402144148616552 0.2371309243739496 1.923383690143966e-07 6.715934070992687 -0.5064716509760392 AALLVTTRPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AALLVTTRPR 10 1 Q9NX02;A0A0G2JPQ2;A0A0G2JMG8;Q9NX02-5;J3KN39;A0A0G2JLX3;Q9NX02-2;Q9NX02-4;A0A0G2JNC8;Q9NX02-3;A0A0G2JPB6;A0A0G2JP37;A0A0G2JLQ8;A0A0G2JPH3;A0A0G2JNK3;Q8WX94-2;Q8WX94-3;A0A0G2JNK1;A0A0G2JMB6;Q8WX94;A0A0G2JM25;K7ERG0 Q9NX02;A0A0G2JPH3 NLRP2;NLRP7 NACHT, LRR and PYD domains-containing protein 2;NACHT, LRR and PYD domains-containing protein 7 0 7870300.0 2279500.0 2591600.0 2999200.0 False True 2988446.5747094 2204943.381977677 2688871.554357879 1.0 0.7378225867036248 0.8997556045047744 21.510964320857724 -10.366282523149465 5.515361559865274 1.0000579429836878 0.8187890958526807 0.6254250652543443 0.06610887768698022 4.7116972509335934e-05 5.413750352026141e-06 0.0640300784296477 0.021336548526510506 4.3024662954754914e-11 10.366282523149465 -0.1812688471310071 AALLVTTRPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AALLVTTRPR 10 1 Q9NX02;A0A0G2JPQ2;A0A0G2JMG8;Q9NX02-5;J3KN39;A0A0G2JLX3;Q9NX02-2;Q9NX02-4;A0A0G2JNC8;Q9NX02-3;A0A0G2JPB6;A0A0G2JP37;A0A0G2JLQ8;A0A0G2JPH3;A0A0G2JNK3;Q8WX94-2;Q8WX94-3;A0A0G2JNK1;A0A0G2JMB6;Q8WX94;A0A0G2JM25;K7ERG0 Q9NX02;A0A0G2JPH3 NLRP2;NLRP7 NACHT, LRR and PYD domains-containing protein 2;NACHT, LRR and PYD domains-containing protein 7 0 3634700.0 1019900.0 0.0 2614800.0 False True 987523.8327650347 0.0 1929905.437681448 1.0 0.0 1.9542874547926354 19.913456040838746 -6.767618752741234 1.5836526271800315 0.4246830470214256 1.964283895346019 0.7213432555773065 0.42119887028031006 0.2702950879925243 1.337479091754726 0.20969136194711702 0.5002338538373692 1.7075807382572242e-07 6.767618752741234 1.5396008483245935 AALLVTTRPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AALLVTTRPR 10 1 Q9NX02;A0A0G2JPQ2;A0A0G2JMG8;Q9NX02-5;J3KN39;A0A0G2JLX3;Q9NX02-2;Q9NX02-4;A0A0G2JNC8;Q9NX02-3;A0A0G2JPB6;A0A0G2JP37;A0A0G2JLQ8;A0A0G2JPH3;A0A0G2JNK3;Q8WX94-2;Q8WX94-3;A0A0G2JNK1;A0A0G2JMB6;Q8WX94;A0A0G2JM25;K7ERG0 Q9NX02;A0A0G2JPH3 NLRP2;NLRP7 NACHT, LRR and PYD domains-containing protein 2;NACHT, LRR and PYD domains-containing protein 7 0 4863200.0 1691900.0 1848400.0 1322900.0 False True 2566735.994458212 1518538.5783848825 1061428.2351523323 1.0 0.5916224269514 0.4135322983914359 21.291503482271708 -13.999999999999998 0.1128853290754805 2.961431010764255 0.09999576314445811 0.9997284400617334 0.0040456106653882894 11.996458470370364 0.10241457837606366 5.335548529362665 0.27832105650903266 1.0000000000000041e-14 13.999999999999998 -2.861435247619797 AALLVTTRPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AALLVTTRPR 10 1 Q9NX02;A0A0G2JPQ2;A0A0G2JMG8;Q9NX02-5;J3KN39;A0A0G2JLX3;Q9NX02-2;Q9NX02-4;A0A0G2JNC8;Q9NX02-3;A0A0G2JPB6;A0A0G2JP37;A0A0G2JLQ8;A0A0G2JPH3;A0A0G2JNK3;Q8WX94-2;Q8WX94-3;A0A0G2JNK1;A0A0G2JMB6;Q8WX94;A0A0G2JM25;K7ERG0 Q9NX02;A0A0G2JPH3 NLRP2;NLRP7 NACHT, LRR and PYD domains-containing protein 2;NACHT, LRR and PYD domains-containing protein 7 0 5198100.0 2279500.0 1252900.0 1665700.0 False True 3122292.7511712457 1197542.7352137524 1272295.966168337 1.0 0.3835459486508835 0.40748772378601233 21.574174382380615 -10.230261368873752 5.485757757929152 1.0000362063330477 0.3955168362184359 0.9988248453372194 0.009774188769730347 4.328427561730273e-06 6.073212113763428e-07 0.009464382486612834 0.0031546058606335883 5.884893816847776e-11 10.230261368873752 -0.6045193701146118 AALLVTTRPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AALLVTTRPR 10 1 Q9NX02;A0A0G2JPQ2;A0A0G2JMG8;Q9NX02-5;J3KN39;A0A0G2JLX3;Q9NX02-2;Q9NX02-4;A0A0G2JNC8;Q9NX02-3;A0A0G2JPB6;A0A0G2JP37;A0A0G2JLQ8;A0A0G2JPH3;A0A0G2JNK3;Q8WX94-2;Q8WX94-3;A0A0G2JNK1;A0A0G2JMB6;Q8WX94;A0A0G2JM25;K7ERG0 Q9NX02;A0A0G2JPH3 NLRP2;NLRP7 NACHT, LRR and PYD domains-containing protein 2;NACHT, LRR and PYD domains-containing protein 7 0 4380500.0 1019900.0 1885000.0 1475600.0 False True 848092.0392308851 1874845.1308567957 1784141.1375964684 1.0 2.210662338673818 2.1037116905547943 19.693861316273022 -10.227869267799836 5.764825557694284 0.9999590555929547 2.1571870146143226 0.993634279367833 0.043662419258661385 2.2978176141887635e-05 3.0777752233026766e-06 0.04227743916090322 0.01409198522031688 5.917397340553989e-11 10.227869267799836 1.1572279590213679 AALLVTTRPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AALLVTTRPR 10 1 Q9NX02;A0A0G2JPQ2;A0A0G2JMG8;Q9NX02-5;J3KN39;A0A0G2JLX3;Q9NX02-2;Q9NX02-4;A0A0G2JNC8;Q9NX02-3;A0A0G2JPB6;A0A0G2JP37;A0A0G2JLQ8;A0A0G2JPH3;A0A0G2JNK3;Q8WX94-2;Q8WX94-3;A0A0G2JNK1;A0A0G2JMB6;Q8WX94;A0A0G2JM25;K7ERG0 Q9NX02;A0A0G2JPH3 NLRP2;NLRP7 NACHT, LRR and PYD domains-containing protein 2;NACHT, LRR and PYD domains-containing protein 7 0 4847200.0 1691900.0 2088200.0 1067100.0 False True 2190197.9023349658 1971989.8343246747 872898.7493706229 1.0 0.9003706159257755 0.39854788849903805 21.062629804364157 -6.939641738538647 0.6628918497506571 1.0056689829802872 0.2646383542005863 0.9981165453709832 0.01142282052316168 0.0879305611701731 0.05535762618003131 0.011089269776890603 0.043259536808998654 1.1491011557636344e-07 6.939641738538647 -0.7410306287797008 down AALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFAR ddPTM_RPMI8226_Bortezomib_8h_R1 2 AALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFAR 39 0 O75390;B4DJV2;A0A0C4DGI3;F8VPA1;H0YH82;F8W1S4;F8VPF9;F8VRI6;F8VX68;F8VRP1;F8VR34 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 0 3088462000.0 1201880000.0 840384000.0 1046198000.0 False True 1823339829.1976104 690410909.2498395 839416506.7351263 1.0 0.3786518005004398 0.46037304362759673 30.76393632606419 -10.65587698076757 6.664631308707621 1.002953519769149 0.41951242206487654 0.9853533819721576 0.03336255780124354 0.0014685484551063266 7.582727585173027e-05 0.032400823928843976 0.01076771922925821 2.20863026599999e-11 10.65587698076757 -0.5834410977042725 AALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AALPSHVVTMLDNFPTNLHPMSQLSAAVTALNSESNFAR 39 0 O75390;B4DJV2;A0A0C4DGI3;F8VPA1;H0YH82;F8W1S4;F8VPF9;F8VRI6;F8VX68;F8VRP1;F8VR34 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 0 2133000000.0 1173700000.0 403730000.0 555570000.0 False True 1519377787.0858521 381262070.592807 454461960.6295909 1.0 0.250933029186943 0.29911057308613376 30.50083348866478 -9.901064947141414 6.818177695695361 1.0000000233125874 0.2750218011365301 0.9966988544151749 0.01966839993562466 6.978978416791208e-09 1.1029411949323689e-09 0.0190438467749515 0.006347948783096995 1.2558421430807218e-10 9.901064947141414 -0.7249782221760573 AALQEELQLCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AALQEELQLCK 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 14078900.0 2404800.0 5156400.0 6517700.0 False True 3152716.0881163273 4387085.219489774 5843310.926193097 1.0 1.3915256232637658 1.853421228831403 21.58816382602196 -6.968940924009675 0.28233608264748017 0.9010621463233544 2.35800481203523 0.9999729036094938 0.0018156532726771434 0.07664785712887454 0.010254537700414039 0.008418574816037427 0.04227264973893209 1.0741355143670356e-07 6.968940924009675 1.4569426657118756 AALQEELQLCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AALQEELQLCK 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 13998100.0 2404800.0 5299800.0 6293500.0 False True 3293919.5472764266 5065637.311905063 4807104.918701102 1.0 1.5378752392703638 1.4593874712804844 21.651373887544853 -10.63347821717902 6.383313228230366 0.997718837414584 1.4986313552754242 0.9817564302859773 0.032042497104192595 0.001043815668127866 5.993453524201285e-05 0.031131871865714936 0.010341671471286448 2.3255291240448022e-11 10.63347821717902 0.5009125178608402 AALQEELQLCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AALQEELQLCK 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 3342050.0 1205900.0 418050.0 1718100.0 False True 1002759.2804280076 415797.88167357165 2077346.7664031512 1.0 0.41465373573615466 2.071630556753838 19.935543887523973 -6.8112223661324816 1.409364708457457 0.6814517001753045 2.10144434316358 0.8630053519198626 0.25394460686960735 0.20513530016212836 0.8028350176074347 0.14166958409138866 0.3275368104886545 1.544463445604347e-07 6.8112223661324816 1.4199926429882757 up AALQEELQLCK(ub)GLVQALQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AALQEELQLCKGLVQALQTK 20 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 50622200.0 21840000.0 21870000.0 6912200.0 True False 28632451.498860843 18607081.248592287 6196991.850504319 1.0 0.6498598713886786 0.21643245779184747 24.771147862800174 -7.400705278602477 0.3897249037229191 1.0380871357413202 1.116999443632678e-10 0.999304308491927 0.008453281054093334 0.11292569709514697 0.03848582339730547 0.015428950175807922 0.05955380376835379 3.9746118351359803e-08 7.400705278602477 -1.0380871356296202 down AALQEELQLCK(ub)GLVQALQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AALQEELQLCKGLVQALQTK 20 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 137911000.0 80380000.0 40497000.0 17034000.0 True False 77828380.89778748 56667663.289065056 12572284.39095372 1.0 0.7281105251757334 0.16153855760490485 26.2137930085501 -7.214665524935655 0.5369065671005245 1.0067254029029502 2.3755593216757264e-23 0.9986645437387532 0.012763914357448912 0.0893534698879162 0.045035256960638204 0.013381639513613985 0.05119939628226569 6.100065173469174e-08 7.214665524935655 -1.0067254029029502 down AALQEELQLCK(ub)GLVQALQTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AALQEELQLCKGLVQALQTK 20 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 650900000.0 207080000.0 183580000.0 260240000.0 True False 314155499.57586557 150818714.6829134 208803449.93275613 1.0 0.4800766336624074 0.6646499908951365 28.226903595084174 -10.083538603427572 5.289076658379009 1.0000060791151764 0.5723633122782955 0.8774107652618237 0.07535175755710484 5.4016640783900365e-06 9.358996160433849e-07 0.07296006229233187 0.02431967517693662 8.250141486284321e-11 10.083538603427572 -0.42764276683688085 AALQEELQLCK(ub)GLVQALQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AALQEELQLCKGLVQALQTK 20 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 72234000.0 21840000.0 19812000.0 30582000.0 True False 29914838.20380785 18936640.330477193 23359161.45606058 1.0 0.6330183102266204 0.7808553500077832 24.834357924323065 -10.087808799992438 5.071219144994371 1.0000069348929916 0.7069368311458495 0.8397322530164227 0.060354218760989245 4.732342121718982e-06 8.510456700619153e-07 0.058439104346869664 0.019479240344112605 8.16941954396609e-11 10.087808799992438 -0.29307010374714215 AALQEELQLCK(ub)GLVQALQTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AALQEELQLCKGLVQALQTK 20 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 181740000.0 80380000.0 40788000.0 60572000.0 True False 66839531.437766954 40568266.948215865 73237325.14671536 1.0 0.6069501996133564 1.095718709741484 25.994198283984375 -6.692691599834667 1.8574219485802168 0.7542007428302883 1.0940605677951025 0.3828460221746295 0.16614323465720987 0.4108799835250551 2.7505551562166475 0.07151179677517705 0.18555330646210239 2.0291231241228384e-07 6.692691599834667 0.33985982496481426 AALQEELQLCK(ub)GLVQALQTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AALQEELQLCKGLVQALQTK 20 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 421888000.0 207080000.0 144790000.0 70018000.0 True False 268069142.1570572 136732309.2193609 57275442.44534932 1.0 0.5100635907554467 0.21365921487446923 27.998029917176623 -8.54391444925424 0.2557168991855783 1.2346060875450011 2.21520969066273e-21 0.9992754452860639 0.008727934302925467 0.18377455565395465 0.06933672098758917 0.14018617229020314 0.1090659935862664 2.858153509501724e-09 8.54391444925424 -1.2346060875450011 down AALQELLSK(ub)GLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AALQELLSKGLIK 13 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 14790800.0 2877600.0 5101200.0 6812000.0 True False 3772561.4667180358 4340120.844321859 6107159.585318045 1.0 1.1504440371908837 1.61883633684861 21.847112976240975 -6.950613568006712 0.5520657790905056 0.9936001897949093 1.7977627106234315 0.9992485628497071 0.00722368996080197 0.08324028184580008 0.03494982100922704 0.007819774871150086 0.03887249970406177 1.1204343942310942e-07 6.950613568006712 0.8041625208285222 AALQELLSK(ub)GLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AALQELLSKGLIK 13 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 49286070.0 7388170.0 10969000.0 30928900.0 True False 7153636.587429785 15348978.902579343 22827693.24288882 1.0 2.1456190449414545 3.1910613523478597 22.770245399031374 -6.972217341084018 0.19819114765069407 0.36301693503623633 5.002471874829199 0.9999949056225723 0.002019639943458645 0.0755895572624289 0.006385136496940093 0.03445281287046736 0.11149971889729979 1.0660624806453418e-07 6.972217341084018 4.639454939792963 AALQELLSK(ub)GLIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AALQELLSKGLIK 13 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 24597600.0 2786700.0 3631900.0 18179000.0 True False 4227627.635059229 2983759.068835782 14585912.68186125 1.0 0.7057762240202546 3.450141294588472 22.011416880597476 -6.8803722551350415 1.077757185749788 0.8167495150364505 3.6459982682111485 0.9739829068393768 0.1984346019511396 0.1272991752161225 0.2703176499463229 0.14178615908163628 0.3431912902878466 1.3171272800731016e-07 6.8803722551350415 2.829248753174698 up AALQELLSK(ub)GLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AALQELLSKGLIK 13 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 15161270.0 2877600.0 5767470.0 6516200.0 True False 3941526.484215999 5512644.104927175 4977207.765351573 1.0 1.3986063843545842 1.262761466980623 21.910323037763867 -10.03915269391205 5.043700988096786 0.9999952882029327 1.330683925669621 0.887652165974937 0.05545845529313026 2.9384266138948856e-06 5.597126676551062e-07 0.05369818322815135 0.017899139478719763 9.1379190422524e-11 10.03915269391205 0.3306886374666883 AALQELLSK(ub)GLIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AALQELLSKGLIK 13 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 25758620.0 7388170.0 10068100.0 8302350.0 True False 6143590.7064265525 10013861.146938613 10038332.999270812 1.0 1.6299687960110254 1.6339521102488375 22.55065067446565 AALRPLVKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AALRPLVKPK 10 2 D3YTB1;F8W727;P62910;D3YTI8 D3YTB1 RPL32 60S ribosomal protein L32 0 17595700.0 1365700.0 9548900.0 6681100.0 False True 1790445.9254576138 8124241.3413206665 5989803.861636585 1.0 4.53755191698639 3.3454257268929646 20.771887516772228 -9.852622941250099 11.11435605086417 0.9999998746732743 3.941488821939677 0.8903222473878052 0.4866834791228444 0.0 1.9231464237392446e-17 0.47122925237926294 0.1570764174597543 1.404032170112743e-10 9.852622941250099 2.9414889472664028 AALRPLVKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AALRPLVKPK 10 2 D3YTB1;F8W727;P62910;D3YTI8 D3YTB1 RPL32 60S ribosomal protein L32 0 18796400.0 5765400.0 1952000.0 11079000.0 False True 5582380.532820398 2731443.7795455246 8177077.537124349 1.0 0.48929731025797907 1.4648011702263921 22.412449040933623 -6.764464497392353 1.595848777606505 0.7050060359411157 1.469150777654514 0.708865246896156 0.21496145581523327 0.2754759834375845 1.3836588797182605 0.10623582603152776 0.25417008363922955 1.720027943948762e-07 6.764464497392353 0.7641447417133984 AALRPLVKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AALRPLVKPK 10 2 D3YTB1;F8W727;P62910;D3YTI8 D3YTB1 RPL32 60S ribosomal protein L32 0 18637900.0 1365700.0 9341000.0 7931200.0 False True 1870636.196654781 8928283.733443737 6058013.908191345 1.0 4.772859495293631 3.2384778606469617 20.83509757829512 -9.538722584300267 10.287868173156129 1.0000000000001767 4.005668677678215 0.8365018819596317 0.626408679263651 0.0 0.0 0.6065175956769756 0.20217253189232517 2.8925269612319114e-10 9.538722584300267 3.005668677678038 AALRPLVKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AALRPLVKPK 10 2 D3YTB1;F8W727;P62910;D3YTI8 D3YTB1 RPL32 60S ribosomal protein L32 0 8485400.0 5765400.0 1569000.0 1151000.0 False True 4794185.550526266 1560547.4855778825 1391668.7783772924 1.0 0.3255083619795605 0.2902826275100109 22.1928543163679 -13.599074987847148 0.4242196250086203 9.999998073024186 0.2892915316618826 0.9998633800045797 0.003817187824784879 21.477875571964606 0.2173740738154465 177.24351315762087 0.008459363157615134 2.5172422483369724e-14 13.599074987847148 -9.710706541362303 AALSASEGEEVPQDK(ub)APSHVPFLLIGGGTAAFAAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AALSASEGEEVPQDKAPSHVPFLLIGGGTAAFAAAR 36 1 O95831-3;O95831;O95831-6;O95831-4 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 1 17816000.0 8164900.0 7287000.0 2364100.0 True False 6789476.116399891 7247743.484643744 2858422.3796366276 1.0 1.0674967199806351 0.4210077965709528 22.69486882811959 -6.88112163390242 1.0735626976057828 1.0424829496781634 0.37420171305967104 0.974577321095949 0.04626454279355759 0.1266394044833188 0.2663426915430517 0.033163315257769665 0.08042821701341211 1.3148565255817856e-07 6.88112163390242 -0.6682812366184923 down AALSGSYVNFGVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AALSGSYVNFGVFR 14 0 E7ESC6;Q9UIA9;E5RIW1 E7ESC6 XPO7 Exportin-7 0 6061900.0 1335700.0 2627200.0 2099000.0 False True 1751115.6349372014 2235232.00074539 1881815.6150297355 1.0 1.2764616774297433 1.0746381206842581 20.73984292462172 -10.327240862215588 3.939362806498181 0.9996079367654274 1.1755498990716486 0.5021852490532475 0.08239412206654184 58643829.41032198 127.1372151697213 208939.46736240984 0.028205699531388573 4.7071619208497856e-11 10.327240862215588 0.17594196230622128 AALVAQNYINYQQGTPHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AALVAQNYINYQQGTPHR 18 0 Q9BS40 Q9BS40 LXN Latexin 0 16155000.0 3593100.0 5304900.0 7257000.0 False True 4710588.895629897 4513429.598338238 6506115.254059457 1.0 0.9581455096889123 1.3811681295507032 22.16747599937377 -6.882574340565677 1.06537503686588 0.9730620986862659 1.4126630969509024 0.9757017902973362 0.029666574328709363 0.12537248742775767 0.2587335577254945 0.021398981395085222 0.05210217593389811 1.310465703572327e-07 6.882574340565677 0.4396009982646365 AALVAQNYINYQQGTPHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AALVAQNYINYQQGTPHR 18 0 Q9BS40 Q9BS40 LXN Latexin 0 9354300.0 2788500.0 2502900.0 4062900.0 False True 2699980.5938477293 3502321.022451068 2998704.605612648 1.0 1.2971652575694728 1.11063931809199 21.36451760724463 -10.282169110329454 4.339846625535708 0.9998436328827209 1.2039022878338 0.6143946961628779 0.07614889592923355 0.00011529696777305028 1.907059317878416e-05 0.07378721036218307 0.02457695047905264 5.221928122636602e-11 10.282169110329454 0.204058654951079 AALVAQNYINYQQGTPHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AALVAQNYINYQQGTPHR 18 0 Q9BS40 Q9BS40 LXN Latexin 0 13528400.0 3593100.0 4513600.0 5421700.0 False True 4921566.169876467 4314174.22752079 4141206.123416509 1.0 0.8765856393289286 0.8414407081964428 22.230686060896662 -13.99999999999996 0.1761676446583866 1.6330670738814714 0.8123902069171612 0.999503257692304 0.0015153956621147076 12.157582297224444 0.13301421331053906 2.6324066113875175 0.02712086372289616 1.000000000000094e-14 13.99999999999996 -0.8206768669643102 AAMDNSEIAGEK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAMDNSEIAGEKK 13 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 3865370.0 1610900.0 1361800.0 892670.0 True False 1559762.8612620789 1905573.8416931846 658852.947474031 1.0 1.221707407593545 0.42240584375814766 20.572895274766232 -6.832712109898779 1.3157727116269107 1.1182598837927427 0.39968420460986 0.9111883671961452 0.1004072803051149 0.17748641976696405 0.5999878161681801 0.059898949062404776 0.13784262670667766 1.4699003391349158e-07 6.832712109898779 -0.7185756791828827 down AAMDNSEIAGEK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAMDNSEIAGEKK 13 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 7279200.0 2857700.0 1685600.0 2735900.0 True False 3699348.983688533 1591794.8782385155 2237994.2727046045 1.0 0.4302905417296896 0.6049697615911742 21.818839975027476 -10.384337550040476 5.08812678842698 1.0003554770350112 0.5176301516603924 0.9104548890079524 0.07131249288815784 0.0002877724106526957 3.482031526003976e-05 0.069097694262211 0.023016008111009966 4.1272659063165806e-11 10.384337550040476 -0.48272532537461876 AAMDNSEIAGEKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAMDNSEIAGEKK 13 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 16945100.0 5943400.0 5823800.0 5177900.0 True False 7693848.461928983 5499700.410468356 4235575.3297405485 1.0 0.7148178753041731 0.5505145247790096 22.87527398391106 -11.678370890368603 0.080461506284617 2.1335902870782073 3.8413515313802925e-14 0.9999351636709649 0.001495266926420941 4.885066560554843 0.05681140107214632 1.3655060041633447 0.3892592346778109 2.097148140228064e-12 11.678370890368603 -2.133590287078169 AANDAGYFNDEMAPIEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AANDAGYFNDEMAPIEVK 18 0 P42765;A0A0B4J2A4;K7EME0 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 7743500.0 2257900.0 582700.0 4902900.0 False True 2186224.2004119717 815375.1487403575 3618683.406152806 1.0 0.37296044412403284 1.6552206335795303 21.06000992835626 -6.773739484391824 1.560092154749587 0.6420581730452686 1.6634792375488952 0.744635565013505 0.26455483242960964 0.2604465274078066 1.2514905546457011 0.1336220233177193 0.31700364873147696 1.6836837316487882e-07 6.773739484391824 1.0214210645036266 AANGVVLATEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AANGVVLATEK 11 0 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 6832600.0 1040100.0 2813000.0 2979500.0 False True 1363581.1723427281 2393311.3649881217 2671209.921382136 1.0 1.755166038906393 1.9589665621393189 20.378969154029587 -10.914772615261011 0.25533357643238075 1.6697488405231286e-13 2.0538361674993455 0.9992135868330227 0.011567839840530132 2.8053967249903993 0.13370989648890938 1.7623014335234397 0.09052798090558192 1.2168229291716876e-11 10.914772615261011 2.0538361674991785 AANGVVLATEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AANGVVLATEK 11 0 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 5640740.0 1900100.0 683540.0 3057100.0 False True 1839782.365562157 956481.08661401 2256353.7989658676 1.0 0.5198881696649762 1.22642429952655 20.81110368414212 -6.723765270282359 1.746147097382291 0.7090754148727152 1.2255324139972823 0.5300210696235713 0.20194575838638326 0.3480691755921033 2.076092923548139 0.09176638006283554 0.22932096665702376 1.889012056195062e-07 6.723765270282359 0.5164569991245671 AANGVVLATEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AANGVVLATEK 11 0 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 6830500.0 1040100.0 2570500.0 3219900.0 False True 1424653.0776456303 2456926.8104932155 2459425.9359220895 1.0 1.7245790214088554 1.7263332207069781 20.44217921555248 AANGVVLATEK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 AANGVVLATEKK 12 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 2944020.0 487420.0 1435100.0 1021500.0 True False 639012.3401819939 1220988.6739759864 915804.9789199037 1.0 1.9107434977362765 1.4331569538376645 19.28548426624674 -10.293448279042154 5.043369491564649 0.9998163733503141 1.6719502257871848 0.7252310707270746 0.19497389009589716 0.00040267202562820965 5.641215807467759e-05 0.18883337170353545 0.06292755244045041 5.088054106430772e-11 10.293448279042154 0.6721338524368706 AANGVVLATEK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 AANGVVLATEKK 12 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 35724800.0 1239200.0 7838600.0 26647000.0 True False 1879956.9976550739 6439740.586738661 21380208.770205013 1.0 3.4254722819570556 11.372711608229967 20.84226823123809 -6.94945307829818 0.5648158396316573 0.8985631458316485 14.282585357451651 0.9991576636229528 0.12857587977454335 0.0837061026073521 0.03687697582907785 0.13703787673300058 0.6613443457539199 1.1234323401083718e-07 6.94945307829818 13.384022211620003 AANGVVLATEK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AANGVVLATEKK 12 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 12381600.0 1239200.0 2006800.0 9135600.0 True False 1604168.8282838773 1895119.815881024 7473014.539171822 1.0 1.1813717998176059 4.65849629254196 20.61339455333054 -6.917706130523736 0.8415709738419898 0.9167551149029849 5.190648915501185 0.9935195176819671 0.13552506993982258 0.09954022335833701 0.11274897464415985 0.1153720471140509 0.3383630172187497 1.2086313903548006e-07 6.917706130523736 4.2738938005981995 up AANGVVLATEKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 AANGVVLATEKK 12 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 19988400.0 1706200.0 2636200.0 15646000.0 True False 1652037.6149266611 3688848.4076013905 11547843.230061162 1.0 2.2329082426886204 6.990060713946762 20.65581510490136 -6.945702791026779 0.6041834009826079 0.9468721430473711 8.521372776476536 0.998819442089441 0.0887383993819116 0.08525857192602361 0.04346724247584231 0.09070434177153738 0.4003332024936034 1.1331755854675297e-07 6.945702791026779 7.574500633429165 AANGVVLATEKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AANGVVLATEKK 12 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 11225000.0 1706200.0 3147700.0 6371100.0 True False 1418780.897475964 3130742.715330471 7703267.553361917 1.0 2.2066428445013018 5.429497653278363 20.436220380335637 -6.954029509535065 0.5127038439042177 0.9419802583843345 6.836204664199775 0.9994807312636518 0.04260656071182188 0.08190695244126478 0.029570018997333317 0.04884845262129304 0.26604081339091434 1.1116561896609135e-07 6.954029509535065 5.89422440581544 AANGVVLATEKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AANGVVLATEKK 12 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 32662400.0 2903900.0 5574500.0 24184000.0 True False 3759155.794426682 5264274.17462067 19782760.148794983 1.0 1.4003873376106077 5.262553943128633 21.8419772769874 -6.926790596864444 0.7726797393803261 0.9337518837140961 5.99430856951024 0.9958689981884004 0.12353106445035673 0.09433906547714992 0.08609723472085389 0.11046380239103204 0.3558261850885003 1.1836121186856062e-07 6.926790596864444 5.0605566857961435 up AANNIASLLTK(ub)SQIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AANNIASLLTKSQIK 15 1 Q9BV44;H7C0R6 Q9BV44 THUMPD3 THUMP domain-containing protein 3 1 8500500.0 2502800.0 1927100.0 4070600.0 True False 2423349.983963459 2696601.0796937384 3004387.744617601 1.0 1.112757586621215 1.2397663418404956 21.20857134541597 -6.9695807535978656 0.2680120913813332 0.9676559064090846 1.3886761678672837 0.9999789215330394 0.0004496264671772895 0.07643898180358971 0.009515945158131072 0.0025203124268337617 0.011845146177785742 1.0725541963876414e-07 6.9695807535978656 0.42102026145819904 AANNIASLLTK(ub)SQIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AANNIASLLTKSQIK 15 1 Q9BV44;H7C0R6 Q9BV44 THUMPD3 THUMP domain-containing protein 3 1 7576200.0 2502800.0 2538900.0 2534500.0 True False 2081189.0928395542 2525222.4417678076 3064452.2317960453 1.0 1.2133556006304158 1.4724525716281438 20.988976620850245 -6.968529457950999 0.29117732517042577 0.9500818162378665 1.7437445399845437 0.9999685306031783 0.0010836725113812457 0.076782814588495 0.010729374479271948 0.004498128203279088 0.023464245104146998 1.0751536708492077e-07 6.968529457950999 0.7936627237466772 AANNIASLLTK(ub)SQIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AANNIASLLTKSQIK 15 1 Q9BV44;H7C0R6 Q9BV44 THUMPD3 THUMP domain-containing protein 3 1 14013600.0 1764800.0 2316400.0 9932400.0 True False 2284568.389408798 2187490.3037207536 8124805.115030232 1.0 0.9575070345286681 3.5563851590946567 21.123490200132352 -6.903183267446728 0.9409123172443139 0.9011815030618584 3.8475371349073253 0.9880848673519426 0.13265031723800685 0.10910031289939388 0.16449470123078366 0.10506790294993643 0.27800791421444454 1.2497315461003082e-07 6.903183267446728 2.946355631845467 up AANSLEAFIFETQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AANSLEAFIFETQDK 15 0 Q9Y4L1;A0A494C039;A0A087X054 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 24801400.0 5531800.0 9055600.0 10214000.0 False True 7252243.370027412 7704539.778452336 9157153.259606352 1.0 1.0623664134458322 1.2626649151697926 22.789995909028466 -6.949909613209793 0.5598437987026555 0.9973782199919616 1.3372229780671452 0.9991941075137043 0.0031809693853193577 0.08352222307378385 0.03611401361047559 0.0034104612375949086 0.016649634982041812 1.1222519967600746e-07 6.949909613209793 0.33984475807518355 AANSLEAFIFETQDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AANSLEAFIFETQDK 15 0 Q9Y4L1;A0A494C039;A0A087X054 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 25521200.0 8571500.0 5945700.0 11004000.0 False True 8299402.424301879 8319849.016415897 8121722.287076127 1.0 1.0024636222066 0.9785912131811468 22.984576032225572 -6.8814376072759895 1.0717154387294816 1.001558105084698 0.9768518194777137 0.9748276545759755 0.0017008299116637086 0.12636599971166332 0.26463809083949164 0.0012208611087537009 0.0029635224093187257 1.3139002422968113e-07 6.8814376072759895 -0.02470628560698429 AANSLEAFIFETQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AANSLEAFIFETQDK 15 0 Q9Y4L1;A0A494C039;A0A087X054 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 25214400.0 5531800.0 7983600.0 11699000.0 False True 7577055.951274018 7630858.153765288 8935937.148468139 1.0 1.0071006737758381 1.179341581470787 22.853205970551357 -6.915573124030025 0.8569326567507314 0.9955601769060863 1.2044718818807645 0.9928598155873265 0.007006661021145913 0.1008470081883413 0.1196354837399967 0.005899461180458601 0.016987979093149145 1.2145820988411369e-07 6.915573124030025 0.20891170497467815 AANSLEAFIFETQDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AANSLEAFIFETQDK 15 0 Q9Y4L1;A0A494C039;A0A087X054 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 14903400.0 8571500.0 3125800.0 3206100.0 False True 7127582.031834027 3108960.6949772807 3876480.686668499 1.0 0.4361872905975242 0.5438703713762837 22.76498130765985 -9.967489885164511 5.9222877202089315 1.0000003914926807 0.49002883098703764 0.9676421437224995 0.04396143364027453 2.2723870884713177e-07 3.968048532030213e-08 0.042565507754769395 0.014188491696947638 1.077730354032326e-10 9.967489885164511 -0.5099715605056431 AAPAALQLFLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAPAALQLFLSR 12 0 Q6F5E8-2;Q6F5E8 Q6F5E8-2 RLTPR Leucine-rich repeat-containing protein 16C 0 4731700.0 1185900.0 2093000.0 1452800.0 False True 1554726.3842719358 1780732.5584501019 1302478.1922416417 1.0 1.1453671697248533 0.8377539645675856 20.568229272646366 -6.778200521513132 1.5427805850573166 1.0825051114662918 0.8354499946188781 0.7609671649115062 0.061429353748075975 0.2534016439826289 1.1911748367022699 0.031364100337519574 0.07412133069012061 1.6664775924450704e-07 6.778200521513132 -0.24705511684741366 AAPAALQLFLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAPAALQLFLSR 12 0 Q6F5E8-2;Q6F5E8 Q6F5E8-2 RLTPR Leucine-rich repeat-containing protein 16C 0 7730900.0 1185900.0 2709200.0 3835800.0 False True 1624359.2777424788 2589498.5858736536 2929863.0407807576 1.0 1.594166156068944 1.803703823979543 20.631439334169258 -11.074330014762163 0.19955961301678535 6.12462943189331e-14 1.9685120074507048 0.9993831677704869 0.008454329981759818 3.2207092110055098 0.11212359743508858 1.5967398778983333 0.13125191783247375 8.426941620056728e-12 11.074330014762163 1.9685120074506435 AAPEASGTPSSDAVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAPEASGTPSSDAVSR 16 0 P31146 P31146 CORO1A Coronin-1A 0 9882400.0 2809600.0 1593000.0 5479800.0 False True 2720410.785897283 2229093.2073852574 4044475.989523783 1.0 0.8193958129194917 1.4867151720212648 21.375393086251986 -6.834631771206878 1.3071056312229417 0.9037625578373223 1.5064296542003166 0.9148208677368281 0.08225174352945668 0.17516425549352127 0.5836425403364431 0.049382171594028815 0.1136540679396813 1.4634174482311139e-07 6.834631771206878 0.6026670963629943 AAPFSLEYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAPFSLEYR 9 0 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 29209500.0 5592500.0 10704000.0 12913000.0 False True 7331821.657847041 9107004.923865216 11576886.630242484 1.0 1.2421203554669453 1.5789918482062462 22.80574026293944 -6.966476726917909 0.3317314140445197 0.9597781165456034 1.8723906523945535 0.9999404291196812 0.0018324896793199957 0.077463353734557 0.013112077109571074 0.0048856266729289085 0.029342041499771942 1.0802475079064023e-07 6.966476726917909 0.9126125358489501 AAPKPPFQSHFCVVSKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAPKPPFQSHFCVVSKPK 18 2 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 9460500.0 2863000.0 1741700.0 4855800.0 False True 3753420.725331439 1481845.1490934265 4353368.396122634 1.0 0.3947985737630238 1.1598402403285653 21.839774581992312 -6.695859627412608 1.8457462617133646 0.6226822313276754 1.1573896985289358 0.39795437544580314 0.25566093973669907 0.4041705099693005 2.673955029676401 0.11063022014660523 0.28596308809856424 2.0143752306657303e-07 6.695859627412608 0.5347074672012604 AAPKPPFQSHFCVVSKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAPKPPFQSHFCVVSKPK 18 2 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 6754520.0 2863000.0 329620.0 3561900.0 False True 3921528.469665839 315056.2984924233 2720652.5796331842 1.0 0.08034017881789594 0.6937735122104103 21.902984643515204 -10.25069020271216 7.263293952652077 1.0000022129054988 0.3870568460139601 0.5710369868009748 0.2504331096710429 8.97405776309673e-06 9.257919056670138e-07 0.242481689844917 0.0808269385912404 5.614483337530103e-11 10.25069020271216 -0.6129453668915388 AAPLDSIHSLAAYYIDCIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAPLDSIHSLAAYYIDCIR 19 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 125420000.0 45842000.0 27210000.0 52368000.0 False True 69545665.49911542 22354162.90729964 42017441.84629019 1.0 0.32143143281278935 0.6041705337743102 26.05145726441686 -10.416683526174225 6.021263819058657 1.0001651326042857 0.4628009832937856 0.8279788538211064 0.11542775461483105 0.0002559551337321039 2.4795723125075284e-05 0.11179620713494492 0.03725414760944633 3.8310381240435834e-11 10.416683526174225 -0.5373641493105001 AAPLDSIHSLAAYYIDCIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAPLDSIHSLAAYYIDCIR 19 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 73484000.0 45842000.0 16302000.0 11340000.0 False True 59343372.68091466 15394779.369390307 9276236.358225888 1.0 0.2594186793556039 0.15631461339589828 25.82258358650931 -13.999999999999998 0.27778364378109216 6.9626117656742235 0.12459183803641707 0.9996002839759088 0.007512931556944652 15.279667105513669 0.1669282912930237 51.69001991397658 0.0412191747123845 1.0000000000000041e-14 13.999999999999998 -6.838019927637807 AAPLEEMEAPAADAIMSPEEELDGYEPEPLGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAPLEEMEAPAADAIMSPEEELDGYEPEPLGKR 33 1 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 18419100.0 3415600.0 3522500.0 11481000.0 True False 3307173.647604915 4929052.619594832 8473781.677382858 1.0 1.4904124018902052 2.562242742687445 21.657167367487432 -6.958273512944127 0.45912552040200605 0.9684837262739522 3.1273151514076374 0.9997006883950499 0.011285887423613776 0.08032381427215941 0.023455052335567383 0.014535152005654698 0.08855245498867753 1.1008457930005781e-07 6.958273512944127 2.1588314251336853 AAPLEEMEAPAADAIMSPEEELDGYEPEPLGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AAPLEEMEAPAADAIMSPEEELDGYEPEPLGKR 33 1 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 64164700.0 10911300.0 11136700.0 42116700.0 True False 9073229.402549237 11076704.38663814 50923107.24438139 1.0 1.2208116752262432 5.612456710294783 23.113184704841593 -6.917343909267 0.84419658409082 0.8935189396532425 6.279109425763964 0.9934106662128112 0.17243138587902443 0.09975976086353575 0.11390006851620445 0.14651457383996905 0.42832738326405084 1.2096398641423498e-07 6.917343909267 5.385590486110721 up AAPRPAPVAQPPAAAPPSAVGSSAAAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAPRPAPVAQPPAAAPPSAVGSSAAAPR 28 1 Q9Y6H1;Q5T1J5 Q9Y6H1 CHCHD2;CHCHD2P9 Coiled-coil-helix-coiled-coil-helix domain-containing protein 2;Putative coiled-coil-helix-coiled-coil-helix domain-containing protein CHCHD2P9, mitochondrial 0 9323820.0 3400200.0 759720.0 5163900.0 False True 3292262.5121753844 1063080.1578874614 3811319.6763206436 1.0 0.3229026099698909 1.1576597134115798 21.650647944547313 -6.690964124637506 1.863241186320423 0.5758826871924313 1.1547893620233016 0.37485566375914003 0.2863090575685219 0.41458465276917483 2.7913606101580486 0.12290046557776574 0.31962333629347395 2.0372103567064712e-07 6.690964124637506 0.5789066748308703 AAPSVTLFPPSSEELQANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAPSVTLFPPSSEELQANK 19 0 P0DOY2;P0DOY3;P0CF74;A0A5H1ZRQ7;A0M8Q6 P0DOY2 IGLC6;IGLC7 Ig lambda-6 chain C region;Ig lambda-7 chain C region 0 26393000.0 22324000.0 4069000.0 0.0 False True 21615336.839539807 5693772.9195546815 0.0 1.0 0.26341356425865914 0.0 24.36555198265434 -8.97548566630373 0.4751459907553488 1.1085097726566857 2.212848163602534e-21 0.9960800185651453 0.026496958326740504 0.49223015637711476 0.1981265419193956 0.16714956169992873 0.055813693910900415 1.0580698365444542e-09 8.97548566630373 -1.1085097726566857 AAPSVTLFPPSSEELQANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAPSVTLFPPSSEELQANK 19 0 P0DOY2;P0DOY3;P0CF74;A0A5H1ZRQ7;A0M8Q6 P0DOY2 IGLC6;IGLC7 Ig lambda-6 chain C region;Ig lambda-7 chain C region 0 26504300.0 22324000.0 0.0 4180300.0 False True 18563395.120884683 0.0 5054381.402476625 1.0 0.0 0.2722767774732226 24.145957258088615 -10.286974818803058 5.04834579590844 1.0002171933376018 0.1361383887364288 0.9306598024959712 0.11115652893745748 0.0002717932266279275 3.838795682274556e-05 0.10765320648725814 0.03587561544960566 5.16446312915947e-11 10.286974818803058 -0.864078804601173 AAQAPSSFQLLYDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAQAPSSFQLLYDLK 15 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 38101300.0 8721300.0 17052000.0 12328000.0 False True 11433708.757189337 14507908.068175398 11052416.818526246 1.0 1.2688715775669073 0.9666519458593572 23.446790111309152 -6.671988564642704 1.9300251939326605 1.171320412969157 0.9678535553469751 0.28804511764520224 0.11415776729022771 0.4565484105535247 3.2804626481911088 0.04758237954088551 0.1268132682565221 2.1281950825011987e-07 6.671988564642704 -0.20346685762218186 AAQAPSSFQLLYDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAQAPSSFQLLYDLK 15 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 47347000.0 13099000.0 11790000.0 22458000.0 False True 12683179.415030096 16497808.48403778 16575576.074441621 1.0 1.3007628406239518 1.3068943939087445 23.596413109320107 -11.858304497534487 0.5989496819509208 3.2605971033580714e-12 1.3061442126849672 0.99996301667714 0.000871128385267949 6.670124488036914 0.2987297301781427 8.613265529224247 0.0010687194064644976 1.3857838714747572e-12 11.858304497534487 1.3061442126817067 AAQAPSSFQLLYDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAQAPSSFQLLYDLK 15 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 37335300.0 8721300.0 10229000.0 18385000.0 False True 11945800.29427058 9777048.957220426 14042841.650960488 1.0 0.8184507288230554 1.1755463263265573 23.510000172832044 -6.7684721807662624 1.5801175397234137 0.8956674946308996 1.177449196706364 0.7247726545902347 0.07648479628226806 0.2688948976685758 1.3247076678196013 0.03815762827738675 0.09096571422588003 1.7042284821394577e-07 6.7684721807662624 0.2817817020754645 AAQAPSSFQLLYDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAQAPSSFQLLYDLK 15 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 29197000.0 13099000.0 8129800.0 7968200.0 False True 10892398.884091938 8086003.153761046 9634313.77920586 1.0 0.7423528315301087 0.8844988034065225 23.376818384754383 -10.104277670854222 4.834854583588598 1.0000087129275008 0.8134258176134791 0.6966996654890532 0.05803085001997441 5.450392893235213e-06 1.0096954036191686e-06 0.05619075247994504 0.01872937630707549 7.865427443240923e-11 10.104277670854222 -0.18658289531402172 AAQAPSSFQLLYDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAQAPSSFQLLYDLK 15 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 40244000.0 11500000.0 16110000.0 12634000.0 False True 14886976.698890066 15213464.338171853 10334741.635787113 1.0 1.0219310909048531 0.6942135965429196 23.827547460147432 -6.890892939814099 1.017105459947232 1.0172336012204932 0.6655308756049454 0.9814629848558286 0.020366305207420436 0.11842084719177831 0.21764948292121372 0.015239205891404399 0.03811504015698941 1.2856035416828427e-07 6.890892939814099 -0.35170272561554783 AAQEEYVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAQEEYVKR 9 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 22923300.0 7238700.0 8497500.0 7187100.0 True False 7008911.43076406 11890596.063877098 5304582.901621659 1.0 1.6964968356834942 0.756834061040973 22.74075896286266 -6.708159971859122 1.8015610707772876 1.4289844480469014 0.7591383835382549 0.4564697472799951 0.29358480854503516 0.37877627247229323 2.3952317084187813 0.1297341391223164 0.33034821057532743 1.958123268258178e-07 6.708159971859122 -0.6698460645086465 AAQEEYVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAQEEYVKR 9 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 27931600.0 6091000.0 7068600.0 14772000.0 True False 9240492.311747124 5807153.102776125 11852307.725202382 1.0 0.6284462891001693 1.282648946110257 23.13953828641956 -6.752669392235758 1.640239723672792 0.7822197992926259 1.2841954139730063 0.6602452637152445 0.15615364131485998 0.2954232840901962 1.5646031484245309 0.07518422361861406 0.18199871882062812 1.7673827332532464e-07 6.752669392235758 0.5019756146803804 AAQEEYVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAQEEYVKR 9 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 18729500.0 4421000.0 8224300.0 6084200.0 True False 6055563.173032724 7860923.231876815 4647237.268032302 1.0 1.2981324787236819 0.7674327119115645 22.52982970746992 -6.754258251111253 1.6339196973433043 1.1744020259516479 0.7660147467516539 0.667152518145465 0.12531351262295629 0.2926763111847631 1.538501661496107 0.06055205166287642 0.1463624738993984 1.7609286073434721e-07 6.754258251111253 -0.40838727919999396 AAQEEYVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAQEEYVKR 9 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 21197100.0 7238700.0 9692800.0 4265600.0 True False 6019299.778782836 9640582.962529842 5157517.238093982 1.0 1.601612034095977 0.8568301011146657 22.521164238296937 -6.691784162472179 1.8602049348151803 1.3765475306680806 0.8593584100605114 0.3786997891812207 0.2543492875612833 0.412862707517501 2.771311714940195 0.10933061014812186 0.28405239367316043 2.0333673114408882e-07 6.691784162472179 -0.5171891206075692 AAQEEYVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAQEEYVKR 9 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 19148100.0 6091000.0 5852100.0 7205000.0 True False 7884919.571559944 5526425.4905906655 5893763.929542998 1.0 0.7008854612194 0.747472929311945 22.910664608512008 -10.203513951958884 5.356202458098666 1.0000149446756177 0.7241791952656687 0.9790515905021876 0.019019254205998704 3.3943979303702207e-06 5.047421960005507e-07 0.018416310855035346 0.006138437899734218 6.258727570778091e-11 10.203513951958884 -0.27583574940994904 AAQEEYVKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAQEEYVKR 9 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 12954620.0 324420.0 7075500.0 5554700.0 False True 425317.7616877492 6019862.980082985 4979952.928444828 1.0 14.153801045587466 11.708781943842036 18.69818157902139 -9.362721022076032 11.152628758913936 1.0000000406576104 12.93129149471475 0.9694660173606108 0.998174868439065 0.0 0.0 0.966478703721781 0.322159553505606 4.3378944240884905e-10 9.362721022076032 11.93129145405714 AAQEEYVKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAQEEYVKR 9 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 7302230.0 3005400.0 965430.0 3331400.0 False True 2909995.22207279 1350931.2336509412 2458806.400142256 1.0 0.4642382995696717 0.8449520402960827 21.47258535369569 -9.984849635270974 6.755231774598755 1.0000000479460023 0.6545951699328822 0.5232384603200058 0.1554257338076652 1.1218189227887535e-07 1.6764087646263373e-08 0.1504903409557678 0.050163439884095405 1.0355006235006003e-10 9.984849635270974 -0.34540487801312003 AAQEEYVKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAQEEYVKR 9 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 12466620.0 324420.0 6957700.0 5184500.0 False True 444366.8411208494 6650285.80796291 3960027.8781291605 1.0 14.965756200864472 8.91161876106817 18.761391640544282 -10.38834666042139 8.48768201461194 0.999929823079714 11.938687480884756 0.8131804523036472 2.471591260030112 0.0032916667708580995 0.00023723005476260637 2.3931188013339226 0.7977026490607023 4.0893411202894995e-11 10.38834666042139 10.938757657805041 AASAAGAAGSAGGSSGAAGAAGGGAGAGTRPGDGGTASAGAAGPGAATK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AASAAGAAGSAGGSSGAAGAAGGGAGAGTRPGDGGTASAGAAGPGAATK 49 1 Q9UKY7;Q9UKY7-2 Q9UKY7 CDV3 Protein CDV3 homolog 0 6742820.0 1718400.0 659020.0 4365400.0 False True 1663850.3326046024 922170.1227439 3221970.7808071673 1.0 0.5542386263194291 1.936454690466944 20.66609423470204 -6.819914408963916 1.372388960007071 0.7597206498709661 1.9665402016320574 0.8841563621555389 0.19605243307319908 0.19359252162592508 0.7165086972893822 0.11226386667345643 0.25873771911854876 1.5138595714573332e-07 6.819914408963916 1.2068195517610913 AASADSTTEGTPADGFTVLSTK(ub)SLFLGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AASADSTTEGTPADGFTVLSTKSLFLGQK 29 1 O75367-2;O75367-3;O75367 O75367-2 H2AFY Core histone macro-H2A.1 1 8384600.0 4224300.0 4160300.0 0.0 True False 4090201.908764917 5821529.485677888 0.0 1.0 1.4232865798636736 0.0 21.963740631460404 -6.852699881600889 1.4000348660477429 1.224732763685677 3.7032731533967144e-23 0.8989228732918426 0.1897201805866424 0.17206561910232898 0.677822424326063 0.10904482448012695 0.22958467990162112 1.4037834514122863e-07 6.852699881600889 -1.224732763685677 down AASAFFTYVSLSQEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AASAFFTYVSLSQEGR 16 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 9788400.0 3355700.0 3831600.0 2601100.0 False True 4399355.196645021 3259940.2154598217 2331963.1235130318 1.0 0.7410040948605092 0.5300692986307182 22.0688606560805 -6.9734651573631945 0.1543969922916817 1.230632869282009 0.03487160112464941 0.9999983459540736 0.00024709800737258286 0.0751934963501081 0.00473947026066321 0.010307143071401645 0.02585613964304057 1.0630038626733186e-07 6.9734651573631945 -1.1957612681573595 AASAFFTYVSLSQEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AASAFFTYVSLSQEGR 16 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 31664900.0 11516000.0 6503900.0 13645000.0 False True 11150430.883539706 9100941.187390449 10070965.158774415 1.0 0.8161963678753689 0.9031906716395327 23.410596125167427 -10.053033403661061 4.35509397225737 1.0000103025700642 0.859693519736771 0.7761995973566711 0.03551527585768079 24606741.223423958 0.4399171310887294 2601.4469160215117 0.012157823567295145 8.850475339835549e-11 10.053033403661061 -0.14031678283329319 AASAFFTYVSLSQEGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AASAFFTYVSLSQEGR 16 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 129232000.0 24831000.0 48344000.0 56057000.0 False True 37670442.38926167 39716635.486603975 44977309.379344024 1.0 1.0543182656629908 1.1939681757537641 25.166929640131467 -6.954859009970992 0.50267808814096 0.9972670056591426 1.2570701633128414 0.9995294860953307 0.0017722051281212265 0.08159129957200857 0.028326678300231813 0.0020680198387665475 0.011521033419828753 1.1095349579369816e-07 6.954859009970992 0.25980315765369877 AASAFFTYVSLSQEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AASAFFTYVSLSQEGR 16 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 15158100.0 3355700.0 3953600.0 7848800.0 False True 4596392.974382689 3778916.879193149 5995075.091110072 1.0 0.8221483455079621 1.3042999422640165 22.13207071760339 -6.806879695221938 1.4279101891729369 0.9027090952318555 1.3121220102246896 0.851438444388048 0.07673321828609 0.21109369555118704 0.8489016498280282 0.042264428231781496 0.09789822332397351 1.559984577409215e-07 6.806879695221938 0.40941291499283405 AASAFFTYVSLSQEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AASAFFTYVSLSQEGR 16 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 23985700.0 11516000.0 5453000.0 7016700.0 False True 9576064.24530138 5423623.606664251 8483859.528444778 1.0 0.56637293440522 0.8859442993615558 23.191001400601703 -10.255714435935909 5.689680124148812 1.0000159496919334 0.7261586168833835 0.49470493141482463 0.13046446342464374 2.6397215846164413e-05 3.4533164743271058e-06 0.1263290244367659 0.04210722450962527 5.549905190083774e-11 10.255714435935909 -0.27385733280854996 AASAFFTYVSLSQEGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AASAFFTYVSLSQEGR 16 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 99881000.0 24831000.0 43025000.0 32025000.0 False True 32144218.992186002 40630620.92798541 26196778.604249034 1.0 1.2640102078032251 0.8149763604652288 24.938055962223917 -6.747346512200441 1.6594713269849428 1.1557308435266391 0.8142501167932277 0.6375771581319045 0.11092754947980196 0.3046846236635878 1.6499590112089342 0.05282177337290864 0.12860603221706793 1.7891777462900517e-07 6.747346512200441 -0.34148072673341145 AASDYAGK(ub)QAHVELAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AASDYAGKQAHVELAER 17 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 17061700.0 4067600.0 4097300.0 8896800.0 True False 5332662.990694432 3485998.8111503087 7976244.480131772 1.0 0.6537069410224167 1.4957338376811784 22.34642472595621 -6.795022930061805 1.4760697663952 0.807710135707506 1.5059877211705224 0.8172216913695098 0.14773408235763505 0.22794658756823918 0.9809217902273545 0.07875604609083285 0.1837467336284869 1.6031607441035792e-07 6.795022930061805 0.6982775854630163 AASDYAGK(ub)QAHVELAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AASDYAGKQAHVELAER 17 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 34073500.0 3520600.0 6206900.0 24346000.0 True False 3408840.48007901 8685347.538555896 17969052.235655703 1.0 2.5478891104797565 5.271309215161402 21.700849658099884 -6.962471380064994 0.3990782383901843 0.8487595825805964 7.06973335660503 0.9998511631862753 0.021540460995762543 0.07882982409755426 0.017953890242232557 0.03504700425278278 0.2282569240937095 1.0902563377313376e-07 6.962471380064994 6.220973774024434 AASDYAGK(ub)QAHVELAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 AASDYAGKQAHVELAER 17 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 97772000.0 13584000.0 11977000.0 72211000.0 True False 20607921.12342361 9839610.773271892 57938464.19879441 1.0 0.4774674123770729 2.8114657394015223 24.296695640888924 -6.847926309901327 1.2450528841126223 0.7215785959089123 2.901110199962403 0.9372401150442148 0.2505470175451053 0.15974601626451074 0.47757121643697387 0.1575479099269133 0.36412589249144683 1.419298324566625e-07 6.847926309901327 2.1795316040534907 up AASDYAGK(ub)QAHVELAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AASDYAGKQAHVELAER 17 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 17902700.0 4067600.0 3660100.0 10175000.0 True False 5571501.642756815 3498384.679667861 7771874.5607029 1.0 0.62790696368472 1.3949335491638348 22.409634787479103 -6.774782185149855 1.5559967596839246 0.7878829186043034 1.400065052238288 0.7485535715164344 0.15704412762451309 0.2587730933596602 1.2370317646450895 0.07952165430613774 0.18848836331216276 1.6796462120125885e-07 6.774782185149855 0.6121821336339847 AASDYAGK(ub)QAHVELAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AASDYAGKQAHVELAER 17 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 29978300.0 3520600.0 12877700.0 13580000.0 True False 2927534.889024664 12808325.274076693 16419515.213174334 1.0 4.375123016328563 5.608648858372667 21.48125493353416 -9.140812255179071 0.3640477570347315 2.088647590308646e-19 5.906076971210991 0.9980442561319012 0.08614838961200598 0.5618525033212068 0.13598258879060476 1.1519813796111724 0.3420576899229703 7.230823233966377e-10 9.140812255179071 5.906076971210991 AASDYAGK(ub)QAHVELAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AASDYAGKQAHVELAER 17 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 144723000.0 13584000.0 11993000.0 119146000.0 True False 17584755.780671563 11325579.00730573 97462650.54119779 1.0 0.6440566561495462 5.542451186517171 24.067821962981373 -6.889427424389706 1.0257881026987978 0.7331774192046395 5.959024723587264 0.9805283387028936 0.3111717711881146 0.11960808250144753 0.22458332805305448 0.23131217285285924 0.5754760648581924 1.289949105241634e-07 6.889427424389706 5.225847304382625 up AASITSEVFNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AASITSEVFNK 11 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 11900300.0 1821400.0 3102200.0 6976700.0 False True 2387873.038462692 2639363.8522808896 6254818.009232002 1.0 1.1053200106401415 2.619409787908507 21.187294700880997 -6.920953305783007 0.8176357786507986 0.9677268970991983 2.868997171305405 0.9944414672500385 0.05515795505972429 0.09761395235671481 0.10273475920510851 0.047765709603175534 0.14440899369327054 1.1996282771386746e-07 6.920953305783007 1.9012702742062069 up AASLK(ub)SNYNLPMHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AASLKSNYNLPMHK 14 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 68541000.0 19549000.0 19988000.0 29004000.0 True False 25628928.31278528 17005868.312613778 26002944.30601357 1.0 0.6635419204840575 1.0145935088921259 24.61126981704487 -10.984797610689352 11.881773211445296 1.1061724493494134 0.8390677146881048 0.21887798664565672 0.1433162108322176 0.07150659551563024 9.14906401370945e-05 0.024617113395757163 0.046255108149560804 1.0356246746127863e-11 10.984797610689352 -0.2671047346613086 AASLK(ub)SNYNLPMHK ddPTM_RPMI8226_Bortezomib_2h_R1 2 AASLKSNYNLPMHK 14 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 101461000.0 18954100.0 21893400.0 60613500.0 True False 18352412.470449775 30635548.792572703 44737005.983977504 1.0 1.6692927342332067 2.4376634982464025 24.12946638561172 -6.969320174511632 0.273935709897566 0.8178756571176024 3.3123025334630354 0.9999765844066684 0.0028423451319077673 0.07652392239259866 0.009816907529524254 0.01470727311190473 0.07108323084359795 1.0731979279273698e-07 6.969320174511632 2.494426876345433 AASLK(ub)SNYNLPMHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AASLKSNYNLPMHK 14 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 57265000.0 16627000.0 18734000.0 21904000.0 True False 25224374.59652265 15390771.330589898 17574664.799135756 1.0 0.6101547244192773 0.6967334207587664 24.58831516435861 -9.980439428814272 5.720852439923927 1.0000005093516886 0.6534440725888391 0.955283384964333 0.0353456047718484 2.2960297935670026e-07 4.0916113646184766e-08 0.03422328463558441 0.011407744886820058 1.0460695759369151e-10 9.980439428814272 -0.34655643676284953 AASLK(ub)SNYNLPMHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AASLKSNYNLPMHK 14 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 76498000.0 19549000.0 14884000.0 42065000.0 True False 26776793.59186079 14226375.665193941 32130113.355869092 1.0 0.5312949669044117 1.1999238536773695 24.674479878567762 -6.718286687813242 1.7655764538805263 0.7143247027325266 1.1987761887252757 0.5043889123505947 0.19727520142552063 0.3586505543416079 2.18403323578562 0.0887527122176956 0.22324466254201772 1.9129926974828656e-07 6.718286687813242 0.4844514859927491 AASLK(ub)SNYNLPMHK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AASLKSNYNLPMHK 14 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 92120800.0 18954100.0 45432700.0 27734000.0 True False 15761173.959001962 45187945.02741509 33533051.172472473 1.0 2.8670418298128157 2.1275731909119715 23.909871661045997 -10.435563221461813 5.842321232119269 0.9992454465195616 2.4973075103623947 0.8453604119869595 0.3018868076829129 0.0029682120831436933 0.0002867650114488209 0.2924175412587901 0.09743354821630301 3.668062935370098e-11 10.435563221461813 1.4980620638428332 AASLK(ub)SNYNLPMHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AASLKSNYNLPMHK 14 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 40670000.0 16627000.0 24043000.0 0.0 True False 21523979.267169137 22704985.91450444 0.0 1.0 1.0548693451464484 0.0 24.35944148645106 -6.985859491160251 1.1438518078845685 1.040926417354548 1.111466155904735e-18 0.9808664262131004 0.0670671714737891 0.09542115715121832 0.24550055192898984 0.04925249101653513 0.091135949434233 1.0330955927929142e-07 6.985859491160251 -1.040926417354548 down AASLK(ub)SNYNLPMHK(ub)MINTDLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AASLKSNYNLPMHKMINTDLSR 22 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 2 19330000.0 4461500.0 4269500.0 10599000.0 True False 4319872.12460163 5974333.615148366 7822803.936815684 1.0 1.3829885336476964 1.8108878483381237 22.042557176172735 -6.969690761612879 0.2654669073936542 0.8876086597649876 2.319054381563587 0.9999798695637128 0.0014860396603249848 0.07640317165859375 0.009388528469808765 0.008626865655200959 0.04005095098599948 1.0722825497958165e-07 6.969690761612879 1.4314457217985992 AASLK(ub)SNYNLPMHK(ub)MINTDLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AASLKSNYNLPMHKMINTDLSR 22 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 2 20426800.0 4461500.0 12029000.0 3936300.0 True False 3709934.9279621467 11964197.389430443 4759362.13060516 1.0 3.2249076120594737 1.2828694365319933 21.82296245160701 -6.613232715714273 2.141655325913593 2.483153262932032 1.289944498487539 0.060732124935238496 0.9584242174133109 0.6036267147806221 5.251120028209796 0.3689433973339881 1.063595652271499 2.4365048728895826e-07 6.613232715714273 -1.1932087644444929 AASLLLEILGLLCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AASLLLEILGLLCK 14 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;H7C0V6 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 2393040000.0 793830000.0 1038000000.0 561210000.0 False True 1204298146.7467124 852760790.0689827 450286597.51291883 1.0 0.7080977350771719 0.3738996017965499 30.16554545670227 -6.989309821658348 0.27565095815051627 1.07847723045755 3.2414671205692065e-12 0.9999771535428779 0.0012226524365269336 0.07429638732588986 0.009777282662530848 0.006318020832618168 0.030088148357168852 1.0249204966015501e-07 6.989309821658348 -1.0784772304543087 down AASLLLEILGLLCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AASLLLEILGLLCK 14 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;H7C0V6 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 1078391000.0 793830000.0 78311000.0 206250000.0 False True 1027628583.7286873 73952924.00909851 168714616.30371168 1.0 0.07196464284864952 0.16417859426558673 29.936671778794718 -10.146389799782703 5.022988077220396 1.0000453387871762 0.11807161855539962 0.9918671751709769 0.037646188028920655 104254158.19062637 105296250.73737729 45420.33222942609 0.01288728833273762 7.138553196306436e-11 10.146389799782703 -0.8819737202317766 AATCEGSESSGFGK(ub)LPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AATCEGSESSGFGKLPK 17 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 19825100.0 9270400.0 5015800.0 5538900.0 True False 8976116.2263604 7018635.097051446 4088095.9265617873 1.0 0.7819233753279212 0.45544150983207715 23.09765992598703 -6.965289593409081 0.35305036373474963 1.0304635851458872 0.1958328876214935 0.9999189866987355 0.002014164517221897 0.07786286037327701 0.014514442965359772 0.0044479135725775725 0.028006157993472586 1.083204377883115e-07 6.965289593409081 -0.8346306975243937 down AATCEGSESSGFGK(ub)LPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AATCEGSESSGFGKLPK 17 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 9409840.0 3247200.0 4393340.0 1769300.0 True False 4447777.592280443 4199227.711967426 1351427.7798773125 1.0 0.9441181859577693 0.30384338061841243 22.08465321832618 -6.924072578425681 0.7939423191073817 1.0121636643304226 0.19026144042369905 0.9952393201609588 0.021791188677208483 0.09583458413967959 0.09363018691437774 0.01919228244490176 0.059932478299468184 1.191042946678061e-07 6.924072578425681 -0.8219022239067235 down AATCEGSESSGFGK(ub)LPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AATCEGSESSGFGKLPK 17 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 20236300.0 9270400.0 7219000.0 3746900.0 True False 7708748.348353751 7180109.814140692 4530359.46629181 1.0 0.9314235579728125 0.5876906680005056 22.878065201421308 -6.939750609645126 0.661885657882797 1.0038753429090912 0.4956748489124984 0.998130963336425 0.0077985368178936565 0.0878807894410073 0.05513049670134147 0.007576977702906003 0.029617104870043747 1.1488131294589731e-07 6.939750609645126 -0.5082004939965927 AATFFGCIGIDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AATFFGCIGIDK 12 0 P55263;A0A5K1VW54;P55263-3;P55263-4;P55263-2;A0A5F9ZHJ1;A0A5F9ZH31;A0A5K1VW94;A0A5F9ZH72;A0A5F9ZGZ8 P55263 ADK Adenosine kinase 0 27932000.0 5574000.0 12879000.0 9479000.0 False True 8456165.513984326 10580641.825913722 7605471.495206709 1.0 1.25123400297878 0.8993995543995931 23.011572184439693 -6.71497527478243 1.7772319614144132 1.1536607455182915 0.9000905269987152 0.48877689675753966 0.10579039792362538 0.3651751880447183 2.251275280948674 0.04731396497457157 0.11949081816682106 1.9276346540039254e-07 6.71497527478243 -0.2535702185195763 AATFFGCIGIDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AATFFGCIGIDK 12 0 P55263;A0A5K1VW54;P55263-3;P55263-4;P55263-2;A0A5F9ZHJ1;A0A5F9ZH31;A0A5K1VW94;A0A5F9ZH72;A0A5F9ZGZ8 P55263 ADK Adenosine kinase 0 21078700.0 5574000.0 9910700.0 5594000.0 False True 7215652.879966373 9359160.832794534 4575949.399287091 1.0 1.297063618287324 0.6341698354132046 22.782698506532142 -6.78486580754678 1.516688650103233 1.1671421338693644 0.6280735889234866 0.7842990137091029 0.1259133921580558 0.24308726118957316 1.1046842147710962 0.06536513352327046 0.15363372433254105 1.6410967766081315e-07 6.78486580754678 -0.5390685449458777 AATFGLILDDVSLTHLTFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AATFGLILDDVSLTHLTFGK 20 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2 P35232 PHB Prohibitin 0 2000710000.0 453750000.0 687620000.0 859340000.0 False True 688371923.5684223 564908838.6004186 689491072.3378981 1.0 0.8206447986315469 1.0016257908423607 29.358613014881083 -10.952680041384205 9.015881061015914 1.0332734770093224 0.9111352947369538 0.24326313753866957 0.07388518067651842 0.04616848449911114 0.0002423156706754294 0.06683796692651524 0.02384633952430682 1.115115772443496e-11 10.952680041384205 -0.12213818227236861 AATFGLILDDVSLTHLTFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AATFGLILDDVSLTHLTFGK 20 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2 P35232 PHB Prohibitin 0 1095070000.0 453750000.0 364780000.0 276540000.0 False True 587388319.7496842 344479672.33260936 226212557.54001677 1.0 0.5864598609645651 0.38511585936270804 29.129739336973532 -12.216651479609368 0.11374263805981769 2.374603786448671 5.219565331652698e-20 0.9997862453580437 0.003742212993983423 6.115836955718413 0.08388749537381279 2.2837102687450117 0.2952622776281767 6.072234296144244e-13 12.216651479609368 -2.374603786448671 AATIIQK(ub)YWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AATIIQKYWR 10 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 4230500.0 1289400.0 1244700.0 1696400.0 True False 1248468.7027818772 1741715.2010247498 1252061.949090869 1.0 1.3950811879735592 1.002878122856412 20.25172822486557 -9.89512876209601 12.231321140785914 0.9999998504977966 1.198979655423408 0.25550346707371774 0.1601162308487857 0.0 0.0 0.1550318738837018 0.051677291294567246 1.2731255615534398e-10 9.89512876209601 0.1989798049256114 AATIIQK(ub)YWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AATIIQKYWR 10 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 4720700.0 1289400.0 1906100.0 1525200.0 True False 1072193.2301052103 1895831.4609687715 1844112.2682719785 1.0 1.768180779114545 1.7199439583208547 20.032133500299846 -10.403667841298272 4.517937115738843 0.9984954122956907 1.744062368718871 0.9968578046157051 0.019692599630641048 0.00029897319179050976 3.946207364195841e-05 0.01910107762135189 0.00635575920049258 3.94759107758078e-11 10.403667841298272 0.7455669564231803 AATILTK(ub)STLENQNWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AATILTKSTLENQNWR 16 1 E9PHA2;Q15003;Q15003-2;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 1 5565300.0 1630300.0 1955100.0 1979900.0 True False 2137339.087847656 1663406.7009201115 1775038.9405418679 1.0 0.778260553216755 0.8304900942645316 21.027384378374066 -10.831282012765879 7.184599858772952 1.0120019655627834 0.8043753237423069 0.9492509981737532 0.021322620844466945 0.004186357727412018 9.830930435145915e-05 0.021084589191077956 0.006881846285676295 1.4747485819167698e-11 10.831282012765879 -0.20762664182047652 AATILTK(ub)STLENQNWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AATILTKSTLENQNWR 16 1 E9PHA2;Q15003;Q15003-2;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 1 12562700.0 3073000.0 3781200.0 5708500.0 True False 2975449.297075155 5291052.878697502 4213272.598670851 1.0 1.7782366125003604 1.4160122314342467 21.504676103196953 -10.114109668362342 4.388196116561412 0.9999340473580055 1.5971244216514953 0.7837076955833877 0.14787748461039626 21606427.708622064 16599829.50891637 14271.97811183599 0.0506223954753887 7.689362434219153e-11 10.114109668362342 0.5971903742934898 AATILTK(ub)STLENQNWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AATILTKSTLENQNWR 16 1 E9PHA2;Q15003;Q15003-2;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 1 6132900.0 1630300.0 2470100.0 2032500.0 True False 2233065.967200912 2360962.814471617 1552465.3606514651 1.0 1.057274101683176 0.6952169722945707 21.090594439896957 -6.866437138657972 1.1528440006970306 1.0317865661089125 0.6754066963088786 0.9609924364557357 0.03138434761074742 0.14031310722581325 0.3507841240339251 0.021170873743227618 0.049833083756105616 1.3600750111764763e-07 6.866437138657972 -0.3563798698000339 AATILTK(ub)STLENQNWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AATILTKSTLENQNWR 16 1 E9PHA2;Q15003;Q15003-2;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 1 9833500.0 3073000.0 3812700.0 2947800.0 True False 2555335.656982556 3792160.2283383077 3564171.350912756 1.0 1.4840164805653142 1.3947957643738569 21.28508137863123 -10.071834226888774 4.825612525708428 0.9999856585147087 1.4394061224730557 0.9700059657902546 0.03642420487742215 25283688.721265975 0.12771819892675368 4097.390998538914 0.012468974153832989 8.475508682449034e-11 10.071834226888774 0.439420463958347 AATIVLQSYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AATIVLQSYLR 11 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 0 21785900.0 4060400.0 6849500.0 10876000.0 False True 6159923.655002138 5627153.209612241 8726353.83287987 1.0 0.913510219407141 1.4166334392462274 22.554481039849488 -6.862596720111394 1.1724529837708597 0.9527054233708323 1.4422443893674533 0.9567247398727577 0.045692185821368754 0.144155986829627 0.37507018321164537 0.03036071945745284 0.07109567139666916 1.3721553393565044e-07 6.862596720111394 0.48953896599662095 AATIVLQSYLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AATIVLQSYLR 11 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 0 24078200.0 4060400.0 10931000.0 9086800.0 False True 5256267.842449842 10322680.240878744 7433095.638441537 1.0 1.963880180821902 1.4141394352874375 22.325607361941938 -10.06149407645832 5.033824998743536 0.9999870003369777 1.689009808058069 0.6768426556964037 0.22443071957457675 155627580.61581275 0.6588496320468566 23450.06947583174 0.07682860481577711 8.679724158856209e-11 10.06149407645832 0.6890228077210914 AATLEGWK(ub)LYHDPNVNGGTELEPVEGNPYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AATLEGWKLYHDPNVNGGTELEPVEGNPYR 30 1 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 59112700.0 4281000.0 7720700.0 47111000.0 True False 5541838.891125945 7291036.257959244 38537281.399680816 1.0 1.3156348282939547 6.953879778315087 22.401933339625252 -6.918433615626696 0.836258427192898 0.8684336073558765 7.831137620571376 0.9937346888141636 0.21651129052733503 0.09910234644006069 0.11045357835387867 0.18501546625947204 0.546178688587561 1.2066085110520307e-07 6.918433615626696 6.962704013215499 up AAVAGLDK(ub)AER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAVAGLDKAER 11 1 P22102;A0A140TA71 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 3825240.0 864670.0 1178600.0 1781970.0 True False 719011.4163758899 1172250.6478662172 2154571.688101637 1.0 1.6303644436896947 2.996575073816707 19.455655152219776 -6.958443302470805 0.45684357073244036 0.9588971479257826 3.7228264660728545 0.9997080372923414 0.014239326784891175 0.08026194735525716 0.023221850609011604 0.018457241468096585 0.11290383885853593 1.1004154961361354e-07 6.958443302470805 2.763929318147072 AAVAIQSQFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAVAIQSQFR 10 0 P48539 P48539 PCP4 Purkinje cell protein 4 0 69822000.0 20485000.0 27718000.0 21619000.0 False True 26856033.377022162 23582582.443917766 19382073.264091406 1.0 0.8781111533803373 0.7217027545353952 24.67874289936062 -6.96772137472264 0.30778713947860536 1.0247344247280532 0.5701235921231163 0.9999587548746298 0.0007315042717349492 0.07704924004121105 0.011663062579206091 0.0024998408650185777 0.013916189908339637 1.0771560505233207e-07 6.96772137472264 -0.45461083260493695 AAVAIQSQFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAVAIQSQFR 10 0 P48539 P48539 PCP4 Purkinje cell protein 4 0 27476900.0 10048000.0 4838900.0 12590000.0 False True 9729031.739997119 6771098.0045301495 9292301.308095993 1.0 0.6959683332816586 0.9551105964527098 23.213864800495617 -10.107094324039252 6.849284866688111 1.0000001336384483 0.825539465475248 0.3766773733918948 0.1057943859265184 2.1581167958052692e-07 2.8191249673019833e-08 0.10243505154990397 0.034144991234637136 7.814580619618455e-11 10.107094324039252 -0.17446066816320027 AAVAIQSQFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAVAIQSQFR 10 0 P48539 P48539 PCP4 Purkinje cell protein 4 0 98185000.0 20852000.0 51160000.0 26173000.0 False True 31634008.485396724 42030098.28509554 20999895.077966586 1.0 1.328636499054427 0.6638392060766125 24.914973041931898 -6.772298753602378 1.5657087119952255 1.1879454181596207 0.6597763302259863 0.7392423061533004 0.1385930507509428 0.26273635083895397 1.271437549671672 0.06975930023789238 0.1657047045703024 1.689278467753147e-07 6.772298753602378 -0.5281690879336345 AAVAIQSQFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAVAIQSQFR 10 0 P48539 P48539 PCP4 Purkinje cell protein 4 0 46680000.0 20485000.0 11470000.0 14725000.0 False True 28058858.086309683 10963217.473782213 11247258.27089439 1.0 0.3907221541254141 0.40084518893454496 24.741952960883513 -10.609133486093299 6.487469174717996 1.001759778458253 0.3957836715299796 0.9997895217437255 0.004132711655133846 0.00010542228089224284 6.351626077629365e-06 0.004010355702550169 0.0013338269512508916 2.459611494167945e-11 10.609133486093299 -0.6059761069282734 AAVAIQSQFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAVAIQSQFR 10 0 P48539 P48539 PCP4 Purkinje cell protein 4 0 25262500.0 10048000.0 8881000.0 6333500.0 False True 8355357.201874622 8833156.290259521 7657805.567204671 1.0 1.057184759052276 0.9165144448266739 22.994270075929894 -6.796364105749811 1.4708760895569897 1.0316989052469814 0.9147463351730732 0.8212518760080607 0.02442098658466188 0.22600231343149038 0.965667641408232 0.013064333612091545 0.030450374420158084 1.5982175460001751e-07 6.796364105749811 -0.11695257007390814 AAVAIQSQFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAVAIQSQFR 10 0 P48539 P48539 PCP4 Purkinje cell protein 4 0 85413000.0 20852000.0 42790000.0 21771000.0 False True 26993325.0543701 40408698.88456701 17808901.389324173 1.0 1.4969885630308821 0.6597520443833202 24.686099364024347 -6.745905011562687 1.6650971930304614 1.2936718897951551 0.6586056893974759 0.631098122657903 0.20880944799222192 0.3072558638988013 1.6747568569600528 0.09912128339221755 0.24167426736234135 1.7951262120357876e-07 6.745905011562687 -0.6350662003976792 AAVATFLQSVQVPEFTPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAVATFLQSVQVPEFTPK 18 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 22420500.0 3631600.0 15603000.0 3185900.0 False True 4761062.768464427 13275093.220017642 2856253.62931074 1.0 2.788262592954476 0.5999193390663824 22.1828522184149 -6.689472400824456 1.8682114988703047 2.121690414862256 0.6075261709107197 0.3679514772080863 0.7563926822470891 0.4178283348165819 2.826976060500116 0.3239380089647172 0.8441430643346102 2.0442198409215964e-07 6.689472400824456 -1.5141642439515364 AAVATFLQSVQVPEFTPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAVATFLQSVQVPEFTPK 18 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 36344800.0 12622000.0 8286800.0 15436000.0 False True 12221321.518933477 11595762.455091111 11392848.529926121 1.0 0.9488141226893312 0.9322108507067856 23.542896959656915 -13.999987978132404 0.15745384350016525 1.2507735102434814 0.9154216391262708 0.9995432594766628 0.0006165457319770389 11.993583811068438 0.12530460295675477 0.9187732500353682 0.015254400310343414 1.0000276817562484e-14 13.999987978132404 -0.33535187111721054 AAVATFLQSVQVPEFTPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAVATFLQSVQVPEFTPK 18 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 30563600.0 3631600.0 13979000.0 12953000.0 False True 4974300.660299847 13361361.55762875 9893768.175408812 1.0 2.6860783997771738 1.9889767127209443 22.246062279937792 -10.495897556088085 5.873838138612468 0.9985368576652979 2.3375275562490594 0.8307533258493409 0.28459057202018173 0.0054567544435489244 0.0004683065407568475 0.2757463070529732 0.09185121216015037 3.192290782437905e-11 10.495897556088085 1.3389906985837614 AAVATFLQSVQVPEFTPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAVATFLQSVQVPEFTPK 18 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 23642900.0 12622000.0 4562600.0 6458300.0 False True 10495752.249408979 4538020.368194804 7808700.670194669 1.0 0.4323673292164782 0.7439867562264897 23.32330223509119 -10.137403193768971 5.457783793089839 1.0000080694453355 0.5881770427213951 0.6995810882905963 0.12721809835252895 1.2491612345267633e-05 1.9742104108383326e-06 0.1231808064797072 0.04105946468790754 7.287806049472303e-11 10.137403193768971 -0.41183102672394034 AAVATFLQSVQVPEFTPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAVATFLQSVQVPEFTPK 18 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 16938900.0 4351900.0 12587000.0 0.0 False True 5633620.338773893 11886522.385137748 0.0 1.0 2.109926063587867 0.0 22.42563091013602 -6.7683344330463875 1.610784471375823 1.641460351349461 2.7143147304240865e-12 0.705970610335825 0.46728664140938725 0.27327768646771405 1.4039665270167547 0.22984581335181237 0.5414212691644469 1.7047691079828992e-07 6.7683344330463875 -1.6414603513467467 AAVDYQK(ub)VVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAVDYQKVVR 10 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 4561400.0 1441100.0 1708500.0 1411800.0 True False 1889296.0556322539 1453598.4596808404 1265720.4789418704 1.0 0.7693862776812885 0.6699429002503773 20.84941736132346 -13.999999999999028 0.11467385044181327 2.104968374774906 0.4992058572046684 0.9997194234002863 0.002315683301286301 11.987250906417776 0.1034920930257504 3.0420998182649948 0.15152494441729492 1.0000000000022374e-14 13.999999999999028 -1.6057625175702377 AAVDYQK(ub)VVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAVDYQKVVR 10 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 7151500.0 1707700.0 2045500.0 3398300.0 True False 1653489.9982477212 2862278.8171415804 2508183.2831852767 1.0 1.7310529970999933 1.516902603489173 20.657082888199405 -10.312218357717791 5.169690369113162 0.9998263994860533 1.6239778002946645 0.9188299377776746 0.08742653209406437 0.00017497626145664065 2.327930228238991e-05 0.08467355971866958 0.02821679190137415 4.872834286183421e-11 10.312218357717791 0.6241514008086112 AAVDYQK(ub)VVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAVDYQKVVR 10 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 4709800.0 1441100.0 1583300.0 1685400.0 True False 1973913.6142631667 1513344.5707270612 1287343.2319025723 1.0 0.7666721379253321 0.6521781007033172 20.912627422846352 -13.999999999103812 0.0932912351203048 2.178750859497842 0.3808163305816165 0.9998267559779871 0.0019050092644068398 12.134798494916012 0.0895344493999203 2.8063980730655396 0.2431307358044542 1.0000000020635492e-14 13.999999999103812 -1.7979345289162256 AAVDYQK(ub)VVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAVDYQKVVR 10 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 8292100.0 1707700.0 3947600.0 2636800.0 True False 1420028.2139372325 3926333.495262748 3188142.6888142894 1.0 2.7649686511343488 2.2451262992688754 20.43748816363368 -10.130528278072623 6.212168104290659 0.9999940264132414 2.505047475201622 0.9178728579508444 0.21222475145982914 1.7558582700171626e-05 2.4566317410546406e-06 0.20548654497351448 0.06849524400473864 7.404090558719305e-11 10.130528278072623 1.5050534487883804 AAVDYQK(ub)VVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAVDYQKVVR 10 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 7897200.0 2688400.0 1838100.0 3370700.0 True False 3480186.796286612 1735808.1191802435 2757267.1863026456 1.0 0.498768664093653 0.7922756299301729 21.730733312996996 -10.247817051146866 5.7773055985222355 1.0000159955193333 0.6455221470119108 0.6604210380278052 0.11982371704200964 2.468821664618854e-05 3.2141537723489052e-06 0.11602404482140362 0.03867293838202893 5.6517500764101764e-11 10.247817051146866 -0.3544938485074225 AAVEEGIVLGGGCALLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAVEEGIVLGGGCALLR 17 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 61577000.0 15454000.0 28525000.0 17598000.0 False True 20260343.65674886 24269181.189579125 15777127.771935835 1.0 1.1978662159313815 0.7787196525010751 24.27215530960836 -6.778306648569793 1.542204401745455 1.1122813672694218 0.7755581316187845 0.7614530018946049 0.08361862341180432 0.25320738277261756 1.1893549399387746 0.0427079069853652 0.10092739231960246 1.6660704107702626e-07 6.778306648569793 -0.33672323565063733 AAVEEGIVLGGGCALLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAVEEGIVLGGGCALLR 17 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 96913610.0 51174610.0 27620000.0 18119000.0 False True 49550100.01711524 38648810.03639718 13373090.341651427 1.0 0.7799945917979456 0.2698902794753631 25.56238463371312 -6.9570549732087255 0.475124414428638 1.0128237107739773 0.01596799008327057 0.9996448944047095 0.005762725714416308 0.0807704156847655 0.025149492823298036 0.007122731870792972 0.04208829862077233 1.1039388739330891e-07 6.9570549732087255 -0.9968557206907067 down AAVEEGIVLGGGCALLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAVEEGIVLGGGCALLR 17 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 412626000.0 20046000.0 362170000.0 30410000.0 False True 30411247.558903787 297537933.85287446 24399450.170823533 1.0 9.783812166093181 0.8023166469433404 24.85810166539201 -6.651257367307118 2.00426426522383 6.694083697198741 0.8401478722221813 0.19918690425570407 3.747854408175082 0.5053757629290461 3.892816523411378 1.515873096550525 4.150969140541961 2.232248977439856e-07 6.651257367307118 -5.85393582497656 AAVEEGIVLGGGCALLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAVEEGIVLGGGCALLR 17 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 77556000.0 15454000.0 27869000.0 34233000.0 False True 21167761.428646803 26637655.4295411 26147870.45076587 1.0 1.2584068239493558 1.2352685728675765 24.335365371131253 -10.254296498976208 5.217393505325375 0.999968248308774 1.2468376984083778 0.9934529327158335 0.009446151448634532 3.4893892372923554e-06 4.987195446982673e-07 0.009147371922906588 0.0030487322705011056 5.568054801743602e-11 10.254296498976208 0.24686945009960382 AAVEEGIVLGGGCALLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAVEEGIVLGGGCALLR 17 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 101730000.0 20046000.0 55197000.0 26487000.0 False True 25949942.16573481 52125238.427937396 21666637.779570512 1.0 2.0086841849214347 0.8349397328592078 24.62922798748446 -6.67925523276596 1.9044014062275145 1.6386302350302107 0.839420849755602 0.3207568145058902 0.42757386959602817 0.44019226729523914 3.0859253076437074 0.18019321408992467 0.4757244437213331 2.09288211765892e-07 6.67925523276596 -0.7992093852746086 AAVENLPTFLVELSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAVENLPTFLVELSR 15 0 Q14974;J3QR48 Q14974 KPNB1 Importin subunit beta-1 0 53217000.0 10901000.0 27998000.0 14318000.0 False True 16537613.969849868 23001538.150627546 11488041.024197666 1.0 1.3908619582342543 0.6946613365834876 23.97924776315967 -6.754358194336509 1.6336462536210066 1.2286189888317387 0.6927977896832116 0.6675457115547017 0.1642911958890912 0.29249877519182405 1.5370979215710634 0.07940031443016914 0.19189410734737095 1.7605234153759833e-07 6.754358194336509 -0.5358211991485271 AAVENLPTFLVELSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAVENLPTFLVELSR 15 0 Q14974;J3QR48 Q14974 KPNB1 Importin subunit beta-1 0 31059700.0 10901000.0 11732000.0 8426700.0 False True 14111559.390834847 11079103.886743171 6893127.065243581 1.0 0.785108405095103 0.4884738018195578 23.75037408525212 -6.96660139550979 0.32941357045463854 1.0363875457056106 0.22749243295015928 0.9999424501131483 0.0015909342145532257 0.07742167153380547 0.012966180452135703 0.0043374565206889745 0.025885392627395785 1.079937456516056e-07 6.96660139550979 -0.8088951127554513 down AAVESLGFILFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAVESLGFILFR 12 0 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 20818800.0 4038400.0 8515300.0 8265100.0 False True 6126548.04658671 6995678.184657429 6631499.362277988 1.0 1.1418629432858098 1.0824202000623504 22.54664299743107 -10.127639180318662 5.1466005568098065 0.9999963686052846 1.1121415716742276 0.8259482033027112 0.02426739830197322 1.011184053337293e-06 1.714498802404805e-07 0.023497568532869804 0.00783226912320325 7.453509677496285e-11 10.127639180318662 0.11214520306894293 AAVESLGFILFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAVESLGFILFR 12 0 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 16036400.0 4038400.0 6707100.0 5290900.0 False True 5227788.408765019 6333843.988985256 4328010.489218471 1.0 1.2115723693724485 0.8278855513666235 22.31776931952352 -6.757006333430496 1.6236576324490106 1.1233508471397509 0.8266842994956726 0.6786324274785952 0.08895419572529922 0.28799035206462953 1.4956184260043477 0.04324065933706819 0.10422698699697067 1.7498211703368735e-07 6.757006333430496 -0.2966665476440783 AAVK(ub)CCPEESLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAVKCCPEESLK 12 1 Q14997;Q14997-2 Q14997 PSME4 Proteasome activator complex subunit 4 1 3068460.0 662510.0 967150.0 1438800.0 True False 907457.8506595591 924418.1150626394 1098985.0730161502 1.0 1.0186898646485378 1.2110590835898165 19.791471109218346 -6.925727961854369 0.7810490049396933 0.9965656693307058 1.2465745054522166 0.9956302342908285 0.0063059812892552825 0.0949172492957381 0.08899350519256423 0.0056052546375024125 0.01783235318159585 1.1865117356900689e-07 6.925727961854369 0.2500088361215108 AAVK(ub)DVEEEKFPTQLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAVKDVEEEKFPTQLSR 17 2 Q2TAY7;Q2TAY7-2 Q2TAY7 SMU1 WD40 repeat-containing protein SMU1;WD40 repeat-containing protein SMU1, N-terminally processed 1 8149600.0 3075600.0 2414900.0 2659100.0 True False 2977966.7614983222 3379182.16353713 1962601.9387099354 1.0 1.1347279651425464 0.6590409147892838 21.505896220729362 -6.8310699758213165 1.323368483419877 1.0719347486450224 0.6459808994296736 0.9079504800717525 0.06073685208049584 0.17949746482980167 0.6144562673971872 0.03603372223555326 0.08291128794873476 1.4754687787976894e-07 6.8310699758213165 -0.42595384921534873 AAVK(ub)GSDGFWVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAVKGSDGFWVGK 13 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 9643300.0 1313500.0 1886900.0 6442900.0 True False 1271803.66147355 2640349.010053511 4755311.20714311 1.0 2.076066526647929 3.739029341709446 20.278444536737624 -6.964756813667559 0.362201359726306 0.8602582993596043 5.012020897572659 0.9999080449000447 0.010804557377177568 0.07804357415090703 0.01515148612676896 0.02221452093341785 0.14185319263138926 1.0845340366923878e-07 6.964756813667559 4.151762598213054 AAVK(ub)GSDGFWVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAVKGSDGFWVGK 13 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 9954000.0 1313500.0 4203700.0 4436800.0 True False 1092233.4479162348 4181053.83373088 5364514.366554618 1.0 3.8279855297487027 4.911508960643029 20.0588498121719 -9.172916197526053 0.33777804311443105 7.09646519315368e-19 5.243915880520855 0.9982962897777101 0.06806224352183196 0.5891956021805054 0.12583078772061268 1.0837232022175296 0.3266275158818109 6.715584259009558e-10 9.172916197526053 5.243915880520855 AAVLFQPCGHMCACENCANLMK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAVLFQPCGHMCACENCANLMKK 23 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 75656000.0 11454000.0 41017000.0 23185000.0 True False 17376555.399565227 33697195.882716306 18602474.587653488 1.0 1.9392333582730343 1.0705501844237169 24.05063878546098 -10.255387854733264 4.32377156932249 0.9997301661982873 1.504891771358323 0.3105419841172671 0.35463842128110956 0.0010417024856663975 0.00017939435165954928 0.3435810563838921 0.11445905820526792 5.554080182948633e-11 10.255387854733264 0.5051616051600357 AAVLFQPCGHMCACENCANLMK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAVLFQPCGHMCACENCANLMKK 23 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 52811900.0 11454000.0 34624000.0 6733900.0 True False 14827428.79209453 32697143.963057898 5508399.2956487965 1.0 2.2051796317167867 0.37150064066304495 23.82176510755343 -6.729417132449754 1.725273722171719 1.7257513108417855 0.37269989476161297 0.5565533126990707 0.5066545887593213 0.337355207593626 1.966962647213008 0.23273957274843468 0.5779269583131448 1.864587925561352e-07 6.729417132449754 -1.3530514160801725 AAVLLEQER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAVLLEQER 9 0 Q13435;E9PJ04;H0YCG1;E9PJT3 Q13435 SF3B2 Splicing factor 3B subunit 2 0 6435600.0 1410800.0 2685200.0 2339600.0 False True 1849572.4622066356 2284578.626827621 2097520.635027905 1.0 1.2351928207787006 1.1340570201426194 20.81876039253185 -10.281490687425851 4.820193221612298 0.9999364761814965 1.1846249204608803 0.8162892602876309 0.04128851771513304 2.8195630424525107e-05 4.202847894426294e-06 0.03999117023068891 0.013325811791583762 5.2300918094486085e-11 10.281490687425851 0.1846884442793838 AAVLLEQER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAVLLEQER 9 0 Q13435;E9PJ04;H0YCG1;E9PJT3 Q13435 SF3B2 Splicing factor 3B subunit 2 0 5197710.0 1961400.0 724810.0 2511500.0 False True 1899136.4306160808 1014230.4128342179 1853662.8066150188 1.0 0.5340482107992637 0.9760556307235334 20.856912119205052 -10.644856768018853 9.644667174045125 1.0000920101559316 0.7550519207613986 0.2905161153189353 0.18044877355642594 0.00035714138471489633 1.3150925800923472e-05 0.174783674055409 0.058239591235632576 2.265391319123988e-11 10.644856768018853 -0.24504008939453303 AAVLLEQER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAVLLEQER 9 0 Q13435;E9PJ04;H0YCG1;E9PJT3 Q13435 SF3B2 Splicing factor 3B subunit 2 0 6750900.0 1410800.0 2774200.0 2565900.0 False True 1932410.8854364546 2651626.670947396 1959887.2663692955 1.0 1.3721857452425288 1.014218705317754 20.88197045405474 -9.534632313456802 7.13606400507023 0.9999979240713665 1.1932022252803856 0.2797453953745279 0.14613943209749594 1.1057048642772644e-10 0.0 0.14149889668183901 0.04716629889394633 2.919898039804843e-10 9.534632313456802 0.1932043012090191 AAVPDAVGK(ub)CR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAVPDAVGKCR 11 1 P05023-4;P05023;P05023-3;P05023-2;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 1 40299000.0 11210000.0 14530000.0 14559000.0 True False 14696418.557794407 12362180.63749641 13052574.339789396 1.0 0.8411696080158245 0.8881466112617499 23.808961284685747 -9.903512375574499 5.24973583460187 1.0000002372257695 0.8646581096371805 0.9171298240510526 0.019178281271880274 5.3253800911993145e-08 1.1121464170939939e-08 0.018569323642255636 0.006189763663763466 1.2487848589431124e-10 9.903512375574499 -0.135342127588589 AAVPDAVGK(ub)CR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAVPDAVGKCR 11 1 P05023-4;P05023;P05023-3;P05023-2;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 1 20065100.0 8054900.0 6089500.0 5920700.0 True False 7799201.608529336 8521069.106322976 4369891.052807311 1.0 1.0925565889980577 0.5602997937671371 22.894895014533784 -6.862039004669399 1.1752886049994444 1.050520902795359 0.5334907826990867 0.9560771016693224 0.04866141832795098 0.14472184339919392 0.37868980184719025 0.03226350637073829 0.07549920326959937 1.3739185756864858e-07 6.862039004669399 -0.5170301200962724 AAVPDAVGK(ub)CR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAVPDAVGKCR 11 1 P05023-4;P05023;P05023-3;P05023-2;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 1 28249700.0 6852700.0 9278000.0 12119000.0 True False 10396046.89947621 7622268.410655124 9723674.338053595 1.0 0.7331891135503786 0.9353242085261764 23.30953171154994 -10.522911741539978 5.272886928344784 1.0005055960145914 0.8342566610382766 0.4726997847805624 0.08252130696662341 0.0004919562401664165 4.4511865900466205e-05 0.08014164474403215 0.026633637299083024 2.999772078571747e-11 10.522911741539978 -0.16624893497631488 AAVPDAVGK(ub)CR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAVPDAVGKCR 11 1 P05023-4;P05023;P05023-3;P05023-2;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 1 32431100.0 11210000.0 7145100.0 14076000.0 True False 15354639.938859241 6829405.856313988 10751538.704319816 1.0 0.4447779878595689 0.7002143161371058 23.87217134620864 -10.401349121028959 6.020171443839016 1.0001064042810894 0.5724961519983421 0.7887925112377157 0.10428144434167114 0.00014896495141566345 1.4813198811627138e-05 0.10099498419503553 0.03365669143781227 3.9687238308140865e-11 10.401349121028959 -0.4276102522827473 AAVPDAVGK(ub)CR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAVPDAVGKCR 11 1 P05023-4;P05023;P05023-3;P05023-2;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 1 21584500.0 8054900.0 4308900.0 9220700.0 True False 6698006.242573634 4285687.100450313 11148705.738300163 1.0 0.639845193515912 1.6644812403185216 22.67530028996806 -6.811715936745036 1.4071520854798831 0.8041046299464709 1.683143171975675 0.8642749206939444 0.15635693916435972 0.2044855954296282 0.7976621565790474 0.08735881692382702 0.20194116252841013 1.542709177956059e-07 6.811715936745036 0.8790385420292042 AAVPDAVGK(ub)CR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAVPDAVGKCR 11 1 P05023-4;P05023;P05023-3;P05023-2;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 1 27045100.0 6852700.0 10415000.0 9777400.0 True False 8870955.236911654 9835396.094479196 7998013.5245959265 1.0 1.1087189408367821 0.9015955228041895 23.08065803364239 -6.764082849832167 1.5971691753950576 1.0628281267740856 0.9006837657689123 0.7074029984163374 0.045758095430821696 0.27610242986940986 1.3890074429443509 0.022595648951339913 0.05408281969312958 1.7215401275337515e-07 6.764082849832167 -0.16214436100517327 AAVPSGASTGIYEALELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAVPSGASTGIYEALELR 18 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5;E5RI09;E5RG95;P13929;P13929-3;P13929-2;E5RGZ4;K7EPM1;K7EKN2;P09104;P09104-2;F5H0C8;F5H1C3 P06733;P13929;P09104 ENO1;ENO3;ENO2 Alpha-enolase;Enolase;Beta-enolase;Gamma-enolase 0 72786000.0 13056000.0 37129000.0 22601000.0 False True 17116542.434483845 31589497.927708432 20262465.32410058 1.0 1.8455536828551686 1.1837942973388598 24.028887968964455 -10.276032585822959 4.873479191427744 0.9998474921871701 1.5146739900975066 0.44644259521018503 0.2701621378371493 0.0004478005906549596 6.65216710698658e-05 0.2616600962920589 0.08719445505134714 5.296237038709096e-11 10.276032585822959 0.5148264979103365 AAVPSGASTGIYEALELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAVPSGASTGIYEALELR 18 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5;E5RI09;E5RG95;P13929;P13929-3;P13929-2;E5RGZ4;K7EPM1;K7EKN2;P09104;P09104-2;F5H0C8;F5H1C3 P06733;P13929;P09104 ENO1;ENO3;ENO2 Alpha-enolase;Enolase;Beta-enolase;Gamma-enolase 0 240904000.0 75130000.0 35124000.0 130650000.0 False True 72745039.2740828 49149196.36924022 96428845.58401437 1.0 0.6756363988485855 1.3255728025755498 26.11634553341874 -6.771028368118593 1.5706374564931536 0.8141943955644209 1.3293597487054287 0.7344142673970055 0.13674071879174968 0.2647817427454248 1.2892561641341092 0.06861891994283502 0.1631798828076327 1.694227129904903e-07 6.771028368118593 0.5151653531410079 AAVPSGASTGIYEALELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAVPSGASTGIYEALELR 18 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5;E5RI09;E5RG95;P13929;P13929-3;P13929-2;E5RGZ4;K7EPM1;K7EKN2;P09104;P09104-2;F5H0C8;F5H1C3 P06733;P13929;P09104 ENO1;ENO3;ENO2 Alpha-enolase;Enolase;Beta-enolase;Gamma-enolase 0 511921000.0 17252000.0 459740000.0 34929000.0 False True 26172545.2901431 377695805.03498524 28025267.840075422 1.0 14.430992509438129 1.0707887799751017 24.641550898070385 -6.645004440690681 2.0266985241568998 9.74980756026004 1.1273898550818515 0.1738685729554743 5.739644217275826 0.5209498654205633 4.095675532368228 2.301565448881829 6.355110797247623 2.2646211515690298e-07 6.645004440690681 -8.622417705178188 AAVPSGASTGIYEALELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAVPSGASTGIYEALELR 18 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5;E5RI09;E5RG95;P13929;P13929-3;P13929-2;E5RGZ4;K7EPM1;K7EKN2;P09104;P09104-2;F5H0C8;F5H1C3 P06733;P13929;P09104 ENO1;ENO3;ENO2 Alpha-enolase;Enolase;Beta-enolase;Gamma-enolase 0 115051000.0 13056000.0 26721000.0 75274000.0 False True 17883156.025133487 25540377.865469445 57495831.516692854 1.0 1.4281806762505613 3.2150830332121805 24.092098030487346 -6.943901425034267 0.6222090001849738 0.9804693133110769 3.7578208472574417 0.9986315608800619 0.0354882056397814 0.08603098062801903 0.04683686796731088 0.03566763727581447 0.15135307816873034 1.1378855306392092e-07 6.943901425034267 2.777351533946365 up AAVPSGASTGIYEALELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAVPSGASTGIYEALELR 18 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5;E5RI09;E5RG95;P13929;P13929-3;P13929-2;E5RGZ4;K7EPM1;K7EKN2;P09104;P09104-2;F5H0C8;F5H1C3 P06733;P13929;P09104 ENO1;ENO3;ENO2 Alpha-enolase;Enolase;Beta-enolase;Gamma-enolase 0 134405000.0 75130000.0 30230000.0 29045000.0 False True 62473923.82333207 30067144.989814803 35118175.2110934 1.0 0.4812751168766137 0.5621253326492334 25.896750808853017 -10.728671375301694 6.90245162800551 1.0064101390311757 0.5217002247630772 0.9790195568562193 0.033006962372806446 0.003265673882690224 0.00012837024945687748 0.03205425932068905 0.010652951298231178 1.8677924892913603e-11 10.728671375301694 -0.4847099142680985 AAVPSGASTGIYEALELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAVPSGASTGIYEALELR 18 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5;E5RI09;E5RG95;P13929;P13929-3;P13929-2;E5RGZ4;K7EPM1;K7EKN2;P09104;P09104-2;F5H0C8;F5H1C3 P06733;P13929;P09104 ENO1;ENO3;ENO2 Alpha-enolase;Enolase;Beta-enolase;Gamma-enolase 0 97125000.0 17252000.0 51044000.0 28829000.0 False True 22333054.087761015 48203356.52871782 23582417.810519766 1.0 2.1583862350082375 1.0559423587051369 24.412677220162834 -6.634552320985544 2.063850009093474 1.7606168896610221 1.0604421731377511 0.1341210002779668 0.4963165696316463 0.5472716501892118 4.448094606378804 0.19628301237997473 0.5497293236993509 2.3197846961032831e-07 6.634552320985544 -0.700174716523271 AAVQFLNNAWGIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAVQFLNNAWGIQK 14 0 Q9UMY1 Q9UMY1 NOL7 Nucleolar protein 7 0 11774600.0 3281100.0 5191000.0 3302500.0 False True 4301553.874217603 4416523.03435952 2960788.9798169173 1.0 1.0267273556263035 0.6883068459430712 22.036426476040358 -6.887799048688094 1.035293627506971 1.0191546619069818 0.6604221564401705 0.9794525404253258 0.022020661797027538 0.1209479402100093 0.2324137983477201 0.016251269419956985 0.04020737384387999 1.294794814129986e-07 6.887799048688094 -0.35873250546681124 AAVQFLNNAWGIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAVQFLNNAWGIQK 14 0 Q9UMY1 Q9UMY1 NOL7 Nucleolar protein 7 0 9833000.0 3281100.0 2390200.0 4161700.0 False True 4494211.338393503 2284593.060665588 3178792.172901942 1.0 0.5083412613796299 0.7073081200578855 22.09963653756325 -10.195927698660268 5.421943297919754 1.000017133489487 0.6078246907187014 0.8381901954877202 0.08122787991456157 1.6823898732130256e-05 2.4950249654021023e-06 0.07865198913240616 0.026216185513040655 6.369015434430726e-11 10.195927698660268 -0.3921924427707856 AAVTIQSK(ub)YR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAVTIQSKYR 10 1 Q8IZT6 Q8IZT6 ASPM Abnormal spindle-like microcephaly-associated protein 1 3296580.0 859740.0 971840.0 1465000.0 True False 1127127.4657340038 826845.260202649 1313415.8532723053 1.0 0.7335862937775134 1.1652771254376164 20.104219247020406 -6.739732812986021 1.6875179004914884 0.8414395610660846 1.165524131737651 0.6038373153804284 0.1119362988365528 0.3182858503820007 1.7795692420800435 0.052475757482036485 0.1288163590782637 1.820820720938447e-07 6.739732812986021 0.3240845706715664 AAVTIQSK(ub)YR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AAVTIQSKYR 10 1 Q8IZT6 Q8IZT6 ASPM Abnormal spindle-like microcephaly-associated protein 1 13767700.0 0.0 4025900.0 9741800.0 True False 0.0 3307446.6904997313 7816328.960017368 0.0 AAVTIQSK(ub)YR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAVTIQSKYR 10 1 Q8IZT6 Q8IZT6 ASPM Abnormal spindle-like microcephaly-associated protein 1 12497000.0 0.0 3682700.0 8814300.0 True False 0.0 3477754.5076465267 7210187.842355418 0.0 AAVVK(ub)FHPIQGHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAVVKFHPIQGHR 13 1 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 1 6446200.0 1724800.0 1823900.0 2897500.0 True False 1670047.1681077878 2552192.781512847 2138557.8268632363 1.0 1.5282159870996674 1.2805373810407312 20.671457419469135 -10.016255761936728 4.30564911762189 0.999977295806023 1.40437668393086 0.7804193470841823 0.10111436785299584 23266914.807231475 37613228.254504554 7122.136631648747 0.037004071105839156 9.632615786862725e-11 10.016255761936728 0.404399388124837 AAVVK(ub)FHPIQGHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAVVKFHPIQGHR 13 1 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 1 4879010.0 1724800.0 2220500.0 933710.0 True False 1434247.6215956772 2208537.7257652567 1128944.4440127395 1.0 1.539858036025983 0.7871335653718765 20.45186269490341 -6.714163475537194 1.7800226933440157 1.3304602530156273 0.7886472954277163 0.48503801125609425 0.2273500555587786 0.36675140706022263 2.2676000890529093 0.10153738814887442 0.2566916508450587 1.9312412294360804e-07 6.714163475537194 -0.541812957587911 AAWEAYLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAWEAYLSR 9 0 P11172;P11172-3;P11172-2;P11172-4 P11172 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 0 8377900.0 2814500.0 2470300.0 3093100.0 False True 3689836.7556567662 2101740.8691539834 2773055.6831102786 1.0 0.5696026703435794 0.7515388530018297 21.815125559860775 -10.206488175930943 5.440286702841951 1.0000163612855575 0.6605707616726655 0.8227222718596265 0.07427513554388913 1.474023738326542e-05 2.1500730011438886e-06 0.07192005346995863 0.023972196916545212 6.216011711891028e-11 10.206488175930943 -0.339445599612892 AAYDIEVNTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAYDIEVNTR 10 0 O75955;A0A140T9R1;O75955-2;A2AB09;A0A140T9X0;A2AB10;A2AB12;A0A140T959;A0A140T9C3;A0A140T905;A2ABJ5 O75955 FLOT1 Flotillin-1 0 1270300.0 1270300.0 0.0 0.0 False True 1665375.6016026982 0.0 0.0 1.0 0.0 0.0 20.6674161625117 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 AAYEAELGDAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAYEAELGDAR 11 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 16807000.0 2779300.0 7991200.0 6036500.0 False True 3643689.2147794897 6798944.109453626 5411900.8861967595 1.0 1.8659506090354325 1.4852805953496446 21.79696848032543 -10.313055787857873 5.631531274336937 0.999908556707277 1.675615602192546 0.8076892500491266 0.15540788231810426 0.0001784478354969512 2.1767226027981806e-05 0.15049318481366838 0.050157678340611245 4.863447276393685e-11 10.313055787857873 0.6757070454852689 AAYEAELGDAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAYEAELGDAR 11 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 14751400.0 2779300.0 5425700.0 6546400.0 False True 3806882.317758392 5185974.63360944 5000275.1473400965 1.0 1.3622629229744878 1.3134829842295757 21.86017854184832 -10.109386464611411 4.496348062572126 0.9999669783041416 1.3378729536151062 0.98460781672648 0.019914326648199854 2291452.5314042866 5151999.022630584 440.0077536742474 0.006817203106778749 7.77344509438407e-11 10.109386464611411 0.33790597531096456 AAYFGIYDTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAYFGIYDTAK 11 0 P05141 P05141 SLC25A5 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed 0 30230000.0 9494400.0 7424600.0 13311000.0 False True 12447250.343900403 6316878.620864128 11933705.408128079 1.0 0.5074918914890809 0.9587422987741241 23.569323743585866 -10.464871693386428 8.945024255121542 1.000004360989829 0.7331170951316026 0.3180510828675672 0.18422220734524078 1.6021855425627395e-05 9.586161808850504e-07 0.17837529697508528 0.05945746175414063 3.428690677576352e-11 10.464871693386428 -0.2668872658582264 AAYFGIYDTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAYFGIYDTAK 11 0 P05141 P05141 SLC25A5 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed 0 11709400.0 3121700.0 1666500.0 6921200.0 False True 3022603.342232191 2331942.140682692 5108330.088450671 1.0 0.7715012115882046 1.690043154877931 21.52736023511029 -6.8408480152377305 1.278393508893527 0.8784518317145246 1.7207760778848165 0.9259102884630147 0.10627939751864311 0.16781154848024918 0.5323627434499527 0.0651782599381578 0.15019871235786772 1.4426201194283974e-07 6.8408480152377305 0.8423242461702919 AAYFGIYDTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAYFGIYDTAK 11 0 P05141 P05141 SLC25A5 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed 0 29336000.0 9494400.0 6027600.0 13814000.0 False True 13004736.256512532 5761280.701392311 10551417.70826044 1.0 0.44301403640594156 0.8113519182656614 23.632533805108757 -9.94631625517127 5.519672122990307 1.000000569517327 0.627182977335034 0.5773382760239201 0.15037331058506137 1.0540046025888073e-06 2.0085630395777202e-07 0.14559855536080946 0.04853277730043582 1.1315760444325857e-10 9.94631625517127 -0.37281759218229304 AAYFGIYDTAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAYFGIYDTAK 11 0 P05141 P05141 SLC25A5 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed 0 11402000.0 3121700.0 3846600.0 4433700.0 False True 2595831.864758365 3825877.6023096815 5360766.170887402 1.0 1.4738541637656553 2.0651438344934614 21.307765510544566 -6.968135258716104 0.2993969891429828 0.8967129191086496 2.660796747542443 0.9999639641166659 0.0026156356425122026 0.07691255497436526 0.011184459625452014 0.00983913542512551 0.05306409546742933 1.0761300064426185e-07 6.968135258716104 1.7640838284337934 AAYLNMSEDPSHPSMALNTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAYLNMSEDPSHPSMALNTR 20 0 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y7I0;A0A2R8Y7M9 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 0 9101500.0 2001200.0 3289100.0 3811200.0 False True 2623592.579648366 2798379.1008113855 3416853.58361188 1.0 1.0666210609524005 1.3023567798281517 21.3231122690983 -6.947694018625942 0.5836185001803018 0.9972186876354556 1.3834915684283324 0.9990076111559525 0.00408624338989139 0.08442529086849952 0.0398991627141521 0.004264739295113891 0.019712111413948914 1.1279919008880786e-07 6.947694018625942 0.3862728807928768 AAYLNMSEDPSHPSMALNTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAYLNMSEDPSHPSMALNTR 20 0 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y7I0;A0A2R8Y7M9 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 0 8965600.0 2001200.0 2582900.0 4381500.0 False True 2741097.7203965327 2468778.937491901 3346679.939825041 1.0 0.9006533839059057 1.2209268990749091 21.38632233062119 -6.823383007448226 1.357135077590686 0.9466278337803362 1.2284415231660062 0.8919950050683851 0.04399013863773936 0.18912211689859562 0.6834963386235722 0.025465242328116762 0.058648218024437065 1.5018169186765265e-07 6.823383007448226 0.28181368938567 AAYNPGQAVPWNAVK(ub)VQTLSNQPLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAYNPGQAVPWNAVKVQTLSNQPLLK 26 1 Q8N163;Q8N163-2;H0YC69;E5RFJ3;E5RGU7;H0YC58 Q8N163;H0YC58 CCAR2 Cell cycle and apoptosis regulator protein 2 1 8006700.0 3110700.0 2797800.0 2098200.0 True False 2586684.877375734 2782727.696080184 2536923.9190193154 1.0 1.075789215926194 0.9807626515345377 21.302672877873867 -6.694186682303773 1.8509507508529612 1.0473239603096998 0.9810674890634485 0.39044773174067604 0.03202627033383322 0.40768152836520644 2.710990524760685 0.013823621819088411 0.0358166526788104 2.022149766933757e-07 6.694186682303773 -0.06625647124625123 AAYNVTLLNFMDPQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAYNVTLLNFMDPQK 15 0 A0A1B0GTY1;A0A1B0GUC3;A0A1B0GV98;A0A1B0GTC5;A0A1B0GU26;A0A1B0GTC3;A0A1B0GVH5;Q9C0B1 A0A1B0GTY1 FTO Alpha-ketoglutarate-dependent dioxygenase FTO 0 6012400.0 1119500.0 3289300.0 1603600.0 False True 1467675.3412534222 2798549.2615909795 1437674.8548173823 1.0 1.9067904072033848 0.9795591807038068 20.485101439845558 -6.651222832040052 2.0037769703564567 1.587827554162474 0.9834239394946392 0.1992133956241683 0.38690782016582054 0.5055170993375998 3.891762200046138 0.15650697960125728 0.42868287607126193 2.2324264938096337e-07 6.651222832040052 -0.6044036146678348 AAYNVTLLNFMDPQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAYNVTLLNFMDPQK 15 0 A0A1B0GTY1;A0A1B0GUC3;A0A1B0GV98;A0A1B0GTC5;A0A1B0GU26;A0A1B0GTC3;A0A1B0GVH5;Q9C0B1 A0A1B0GTY1 FTO Alpha-ketoglutarate-dependent dioxygenase FTO 0 3628950.0 993650.0 0.0 2635300.0 False True 962107.124646512 0.0 1945035.8726946297 1.0 0.0 2.021641689234196 19.875838012498626 -6.7722115198998365 1.5660116717893742 0.42804441405464677 2.0339674541879575 0.7389303982605054 0.42171107590718965 0.2628735328563197 1.2725775742461498 0.21222290780684128 0.5041558871607855 1.689617815413059e-07 6.7722115198998365 1.6059230401333107 AAYNVTLLNFMDPQK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AAYNVTLLNFMDPQK 15 0 A0A1B0GTY1;A0A1B0GUC3;A0A1B0GV98;A0A1B0GTC5;A0A1B0GU26;A0A1B0GTC3;A0A1B0GVH5;Q9C0B1 A0A1B0GTY1 FTO Alpha-ketoglutarate-dependent dioxygenase FTO 0 10864300.0 1119500.0 4449700.0 5295100.0 False True 1533409.4033499504 4253097.540809828 4044506.4360076613 1.0 2.773621663932889 2.637590735502119 20.54831150136845 -10.101603414861751 4.088588802477492 0.999639508400278 2.7056062002556276 0.9952519843609309 0.055534395768388554 7407381.984890203 13694798.53402634 35369.083889165915 0.020323506464017996 7.914009825813678e-11 10.101603414861751 1.7059666918553495 AAYSNFWCGMTSQGYYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAYSNFWCGMTSQGYYK 17 0 Q8NBJ5;M0QYH0 Q8NBJ5 COLGALT1 Procollagen galactosyltransferase 1 0 5257900.0 1047000.0 2744700.0 1466200.0 False True 1372627.1391624233 2335201.4587568063 1314491.6887835169 1.0 1.701264234205471 0.957646582440166 20.38850835392377 -6.659403950167582 1.9748720908684618 1.4516175574495502 0.9607439848827806 0.23309250832883177 0.29862530460139886 0.48588353065850504 3.6421999466841664 0.12218995821132735 0.33104658693433703 2.1907662907469436e-07 6.659403950167582 -0.49087357256676967 AAYSNFWCGMTSQGYYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAYSNFWCGMTSQGYYK 17 0 Q8NBJ5;M0QYH0 Q8NBJ5 COLGALT1 Procollagen galactosyltransferase 1 0 5328500.0 1047000.0 1642600.0 2638900.0 False True 1434104.1941111193 1570024.5006481865 2015646.169851491 1.0 1.0947771487561355 1.4055088731546599 20.45171841544666 -6.9494402190606825 0.5649655295134016 0.9960367797123875 1.519226481907667 0.9991565475960364 0.0050300234381076584 0.08371149815387567 0.036900123881631545 0.005360125318140821 0.02585895667451493 1.1234656048578767e-07 6.9494402190606825 0.5231897021952796 AAYVLFYQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AAYVLFYQR 9 0 Q9Y4E8-2;Q9Y4E8-3;Q9Y4E8;P51784;G5E9A6;Q13107-2;Q13107 Q9Y4E8-2;P51784;Q13107-2 USP15;USP11;USP4 Ubiquitin carboxyl-terminal hydrolase 15;Ubiquitin carboxyl-terminal hydrolase 11;Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 4 0 18755300.0 4059000.0 8080000.0 6616300.0 False True 5321388.307411911 6874495.495593309 5931708.744031083 1.0 1.2918612772569422 1.1146919565649973 22.34337125169065 -10.091489542850763 4.584867117873597 0.9999861104651325 1.2032766169172338 0.6370552295199328 0.07232907231650218 50304861.37186103 1.280291701741339 7376.334400376238 0.024760165291286575 8.100474461534804e-11 10.091489542850763 0.20329050645210123 AAYVLFYQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AAYVLFYQR 9 0 Q9Y4E8-2;Q9Y4E8-3;Q9Y4E8;P51784;G5E9A6;Q13107-2;Q13107 Q9Y4E8-2;P51784;Q13107-2 USP15;USP11;USP4 Ubiquitin carboxyl-terminal hydrolase 15;Ubiquitin carboxyl-terminal hydrolase 11;Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 4 0 7738600.0 3056900.0 1941800.0 2739900.0 False True 2959860.382762459 2717170.866353224 2022237.9947618914 1.0 0.9180064310389089 0.6832207378898467 21.497097694554487 -6.95249284196127 0.5307703631796051 1.00368256564401 0.5868721786691465 0.999382675508661 0.0033354574987561466 0.0824999038942953 0.03193702654000889 0.0037169857080384143 0.019417478793542445 1.1155965384539681e-07 6.95249284196127 -0.4168103869748635 AAYVLFYQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AAYVLFYQR 9 0 Q9Y4E8-2;Q9Y4E8-3;Q9Y4E8;P51784;G5E9A6;Q13107-2;Q13107 Q9Y4E8-2;P51784;Q13107-2 USP15;USP11;USP4 Ubiquitin carboxyl-terminal hydrolase 15;Ubiquitin carboxyl-terminal hydrolase 11;Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 4 0 15633100.0 4059000.0 5094700.0 6479400.0 False True 5559721.990350551 4869599.308080062 4949099.16743179 1.0 0.8758710087539872 0.8901702595959732 22.406581313213543 -9.980305636373998 5.102087244266469 1.0000007337357084 0.8830206341738992 0.9889177004857661 0.005837644714916105 4.8719920874578124e-08 9.739866166747755e-09 0.005652310647559351 0.0018840917296223119 1.0463918866439446e-10 9.980305636373998 -0.11698009956180921 AAYVLFYQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AAYVLFYQR 9 0 Q9Y4E8-2;Q9Y4E8-3;Q9Y4E8;P51784;G5E9A6;Q13107-2;Q13107 Q9Y4E8-2;P51784;Q13107-2 USP15;USP11;USP4 Ubiquitin carboxyl-terminal hydrolase 15;Ubiquitin carboxyl-terminal hydrolase 11;Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 4 0 10104600.0 3056900.0 3372100.0 3675600.0 False True 2541947.793631621 3353933.8279905585 4444150.965945768 1.0 1.3194345833510892 1.7483250352661703 21.277502969988763 -6.967033245583699 0.32124758458855174 0.9421168421956736 2.1395018745873116 0.9999491315851092 0.002186655223135709 0.07727759214718635 0.012461979862154663 0.006468600212921151 0.0376848006556884 1.0788641311720471e-07 6.967033245583699 1.197385032391638 AAYVLFYQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AAYVLFYQR 9 0 Q9Y4E8-2;Q9Y4E8-3;Q9Y4E8;P51784;G5E9A6;Q13107-2;Q13107 Q9Y4E8-2;P51784;Q13107-2 USP15;USP11;USP4 Ubiquitin carboxyl-terminal hydrolase 15;Ubiquitin carboxyl-terminal hydrolase 11;Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 4 0 41851000.0 0.0 26141000.0 15710000.0 False True 0.0 24686230.37021421 12850941.198212408 0.0 ACAAQTK(ub)ATFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ACAAQTKATFLK 12 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 33970000.0 11377000.0 19053700.0 3539300.0 True False 14915357.175024724 16210962.230740895 3173087.1873629102 1.0 1.0868638303805167 0.21273960456516192 23.830295190223048 -6.882453776552278 1.065973969029786 1.0558095678818502 0.14778888822262762 0.9756132998426743 0.06140220685436305 0.125480736236307 0.2593155589334818 0.044268118860865985 0.10775549541941593 1.310829551016095e-07 6.882453776552278 -0.9080206796592226 down ACAAQTK(ub)ATFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ACAAQTKATFLK 12 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 61896600.0 20965800.0 35164800.0 5766000.0 True False 20300252.155098703 49206288.02200941 4255711.623707823 1.0 2.423924966353215 0.20963836267614733 24.274994311851106 -6.733051344369728 1.7120795724526496 1.853982856949124 0.21019726718919274 0.5733693588842415 0.5984537531641316 0.3305449511246159 1.8994997417000035 0.2768477312968605 0.6846249859063919 1.8490500025249967e-07 6.733051344369728 -1.6437855897599312 ACAAQTK(ub)ATFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ACAAQTKATFLK 12 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 179906000.0 27609000.0 47097000.0 105200000.0 True False 41884871.48826576 38692172.37945942 84407173.88920203 1.0 0.9237744083875059 2.0152186431525543 25.31992591123769 -6.890145985366392 1.0214910026203066 0.941560690026465 2.1093716618930913 0.9809925440837255 0.06859176720670726 0.11902587599273122 0.22114287019493478 0.05115280517241033 0.12759536642606287 1.2878165874588384e-07 6.890145985366392 1.1678109718666263 up ACAAQTK(ub)ATFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ACAAQTKATFLK 12 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 17881100.0 11377000.0 1989500.0 4514600.0 True False 15583384.351864565 1901597.3116032877 3448344.461105589 1.0 0.1220272354622223 0.22128341207813382 23.89350525174594 -10.41720899671296 5.917578499434004 1.0002947810589613 0.1716553237701785 0.9893462500978202 0.04052116442142681 0.00015764304181842552 1.552527550641197e-05 0.039247772300151466 0.013078149581092975 3.826405598470518e-11 10.41720899671296 -0.8286394572887827 ACAAQTK(ub)ATFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ACAAQTKATFLK 12 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 66037100.0 20965800.0 45071300.0 0.0 True False 17433991.64242268 44828491.96094737 0.0 1.0 2.5713269158547027 0.0 24.055399587285383 -6.742117409466846 1.6844138701554003 1.9334298409667356 1.7239767443322993e-06 0.6108539418507438 0.6602103907970148 0.3146907028211101 1.7549111800634878 0.3102893345109426 0.758053473837713 1.8108504715467094e-07 6.742117409466846 -1.9334281169899914 ACAAQTK(ub)ATFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ACAAQTKATFLK 12 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 114764000.0 27609000.0 68744000.0 18411000.0 True False 35740394.75475272 64918335.96916743 15060386.912812773 1.0 1.816385532802059 0.42138278035695337 25.09105223333014 -6.748095559281319 1.657090544706796 1.4811347340961447 0.4190315716993753 0.6407010054880845 0.34302051133281697 0.303353202304835 1.6383471384505943 0.16357195283054896 0.397875036333146 1.7860945312015365e-07 6.748095559281319 -1.0621031623967694 ACADATLSQITNNIDPVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ACADATLSQITNNIDPVGR 19 0 P62873;P62873-2;F6UT28;B1AKQ8 P62873 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0 6667800.0 3899400.0 0.0 2768400.0 False True 3775615.6814236487 0.0 2043272.98978022 1.0 0.0 0.5411761053523794 21.848280490082686 -10.185856612532483 5.691778662941264 1.0000169452863108 0.2705880526761599 0.707789003468479 0.22093421985010805 4.7508853841528236e-05 6.795307112161491e-06 0.21392359731724356 0.07130621284055065 6.518435724137147e-11 10.185856612532483 -0.7294288926101509 ACANPAAGSVILLENLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ACANPAAGSVILLENLR 17 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 158175900.0 20881000.0 66028000.0 71266900.0 False True 27375193.211891647 56176879.77512812 63892884.82837682 1.0 2.052108978384312 2.3339701873089274 24.706365811385776 -10.446113966815952 0.28355513075338884 6.673816006963847e-12 2.4406855402572734 0.9990741535634111 0.017467196080421188 2.01215641467947 0.1372450480733477 1.5655232273848332 0.10844256358134298 3.580024783762001e-11 10.446113966815952 2.4406855402505996 ACANPAAGSVILLENLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ACANPAAGSVILLENLR 17 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 71437000.0 42816000.0 11744000.0 16877000.0 False True 41456829.51629353 16433440.444150925 12456407.400852738 1.0 0.3963988716911453 0.3004669567400727 25.305106452245454 -13.999999999999998 0.2588773685036902 5.39290656061894 0.2650256139868268 0.9995600514756114 0.006494648439639244 14.367783665799166 0.16100612036871384 32.996382585104634 0.042189617602424685 1.0000000000000041e-14 13.999999999999998 -5.1278809466321125 ACANPAAGSVILLENLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ACANPAAGSVILLENLR 17 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 177755200.0 4834200.0 163140000.0 9781000.0 False True 7333834.827359709 134026392.38136211 7847781.062835414 1.0 18.275076482682884 1.0700787851886668 22.806136343359512 -6.51126259490497 2.5601648861344977 9.999999999999998 1.0565443294733732 0.2446882469772501 7.063138969347392 0.5861724785544813 7.179383001106737 2.711562225592796 9.029517021211797 3.0813242730446034e-07 6.51126259490497 -8.943455670526625 ACANPAAGSVILLENLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ACANPAAGSVILLENLR 17 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 163445000.0 20881000.0 84770000.0 57794000.0 False True 28601269.98780733 81024581.10309677 44144247.50479249 1.0 2.8329015158291013 1.5434366209476398 24.769575872908668 -10.491625594169529 5.143052641345369 0.9971140957941327 2.188169068388392 0.5309739065522583 0.5264218389485961 0.017441358653995116 0.0017240199852483205 0.5103420268630183 0.1699019179439721 3.22384687614737e-11 10.491625594169529 1.1910549725942594 ACANPAAGSVILLENLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ACANPAAGSVILLENLR 17 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 61876100.0 42816000.0 4569100.0 14491000.0 False True 35603401.070408486 4544485.351404658 17521001.10118621 1.0 0.12764188854928735 0.4921159376469981 25.08551172767973 -10.625856004765637 6.490979687488113 1.0025725523677973 0.3098789134263201 0.8269989134147324 0.1487959074625825 0.005551876891448174 0.00032001314362577687 0.14439400221999465 0.04802367263220016 2.3667042749098433e-11 10.625856004765637 -0.6926936389414772 ACANPAAGSVILLENLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ACANPAAGSVILLENLR 17 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 24747800.0 4834200.0 12684000.0 7229600.0 False True 6257967.196328208 11978124.249867894 5913886.981960313 1.0 1.9140599293802505 0.9450172550329475 22.57726266545196 -6.659379745418749 1.975403033278462 1.5886762278465654 0.9490861389317018 0.23288385510270038 0.3892449182028677 0.485888197022689 3.6443126141760445 0.15924533481842362 0.4313841418425938 2.190888393209085e-07 6.659379745418749 -0.6395900889148636 ACEDPPAPWEEK(ub)SR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ACEDPPAPWEEKSR 14 1 A0A087WTF1;Q6IPU0 A0A087WTF1 CENPP Centromere protein P 1 13447200.0 4181500.0 4838400.0 4427300.0 True False 6343641.208598041 3974949.71740826 3552242.2144454746 1.0 0.6266038047707828 0.5599689669760702 22.596879744966582 -13.999999999999998 0.2424086108166574 3.5006863243615154 0.5311724767727699 0.9995290222098296 0.004202526289707561 13.709569989084224 0.15581731346487246 16.619047121158285 0.032105551446207456 1.0000000000000041e-14 13.999999999999998 -2.9695138475887455 ACEDPPAPWEEK(ub)SR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ACEDPPAPWEEKSR 14 1 A0A087WTF1;Q6IPU0 A0A087WTF1 CENPP Centromere protein P 1 12174500.0 4181500.0 3950000.0 4043000.0 True False 5413034.179687729 3730179.0276709446 3307215.484683182 1.0 0.6891105623659916 0.6109725848570147 22.36800606705903 -13.999999999999998 0.19392561905019642 2.68978116057052 0.5570771178902281 0.9994877244674352 0.003803053922629059 12.41737810271685 0.13965121355775864 7.93973916746969 0.05210600528229195 1.0000000000000041e-14 13.999999999999998 -2.1327040426802917 ACGDSTLTQITAGLDPVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ACGDSTLTQITAGLDPVGR 19 0 P62879;C9JIS1;C9JXA5;C9JZN1 P62879 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0 7194940.0 824740.0 3298500.0 3071700.0 False True 1081242.1267935222 2806376.657452298 2753869.9498269893 1.0 2.5955117618056085 2.5469502913225632 20.044258196938465 -10.07311291964768 4.564225059367138 0.9999079642730773 2.571231026629519 0.999284097545335 0.019825137529619622 3440818.038571473 0.6685608020650085 3341.6719855428555 0.006786671860888128 8.450590952307276e-11 10.07311291964768 1.5713230623564418 ACGDSTLTQITAGLDPVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ACGDSTLTQITAGLDPVGR 19 0 P62879;C9JIS1;C9JXA5;C9JZN1 P62879 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0 8575540.0 824740.0 2852500.0 4898300.0 False True 1129668.6657604633 2726467.1180439233 3741422.423655136 1.0 2.413510439548695 3.3119644166960307 20.107468258461356 -8.422106093542592 0.20283220925565468 1.9535403079950774e-20 4.356556036555115 0.9997027978606938 0.01640568742469401 0.1301303617702688 0.050251237106247855 0.4674809864959673 0.41996870018580984 3.783501464927914e-09 8.422106093542592 4.356556036555115 ACGQIFCGK(ub)CSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ACGQIFCGKCSSK 13 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 11396300.0 4715000.0 4410700.0 2270600.0 True False 6181410.660124945 3752640.7527739448 2035660.0931331695 1.0 0.6070848482825265 0.3293196658595762 22.559504682555417 -8.061783396771272 0.2098428212019252 1.2412492845542358 5.106369719228468e-09 0.9997888862957499 0.003997799173733269 0.09556866266608476 0.03905154260543147 0.08351714911428115 0.10494423995299154 8.673943785556451e-09 8.061783396771272 -1.241249279447866 down ACGQIFCGK(ub)CSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ACGQIFCGKCSSK 13 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 29456300.0 6185300.0 11615000.0 11656000.0 True False 9383552.306000592 9542212.5015908 9352186.490993723 1.0 1.0169083296406571 0.9966573623736491 23.161702752626624 -6.685148143345338 1.8834529694852022 1.0106482285306395 0.9967308055483323 0.3478734197119243 0.007158227397869062 0.4272023096705503 2.93419180979171 0.0030446580983754428 0.00797792141294559 2.0646757486424885e-07 6.685148143345338 -0.013917422982307248 ACGQIFCGK(ub)CSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ACGQIFCGKCSSK 13 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 11119000.0 4715000.0 3662900.0 2741100.0 True False 6458262.918083972 3501060.966409492 2093708.6347265563 1.0 0.5421056731224224 0.32419067809455404 22.62271474407831 -11.083769414930083 0.13982195694120111 2.0266773944594147 3.904495330939294e-24 0.9997073319272792 0.0048181065821865515 3.383296711089426 0.08302542032965426 1.3312271980443646 0.22439995135410326 8.24575800524098e-12 11.083769414930083 -2.0266773944594147 ACGQIFCGK(ub)CSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ACGQIFCGKCSSK 13 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 20521600.0 6185300.0 7485100.0 6851200.0 True False 8006992.7804908585 7068547.605068288 5604351.899248439 1.0 0.8827968001033916 0.6999321783958036 22.932829074719074 -6.964595070817261 0.364942639257647 1.0148939347520167 0.5615201184392601 0.999904541749065 0.0012063798783790679 0.0780987394215007 0.015346614884999466 0.002430455638365277 0.015574002679179329 1.0849380213213329e-07 6.964595070817261 -0.45337381631275664 ACGVSRPVIACSVTIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ACGVSRPVIACSVTIK 16 1 P55769;B1AHD1;A0A3B3IUA2;A0A3B3IRU2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 0 197485100.0 51525800.0 72622300.0 73337000.0 False True 67550822.77655695 61787335.91950831 65748790.73817806 1.0 0.914679250079411 0.9733233147383028 26.00947000605605 -10.036563325468299 4.691251360518914 1.000001692210759 0.9440012824069943 0.5486869537779508 0.023941339149228722 4.2374675669373163e-07 8.700124541002925e-08 0.02318180265839503 0.007727033983335286 9.192564261564798e-11 10.036563325468299 -0.05600040980376475 ACGVSRPVIACSVTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ACGVSRPVIACSVTIK 16 1 P55769;B1AHD1;A0A3B3IUA2;A0A3B3IRU2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 0 55193100.0 36574000.0 6502100.0 12117000.0 False True 35412978.389595464 9098422.438003572 8943194.19779183 1.0 0.25692338943952653 0.2525400179392816 25.077774850137473 ACGVSRPVIACSVTIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ACGVSRPVIACSVTIK 16 1 P55769;B1AHD1;A0A3B3IUA2;A0A3B3IRU2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 0 345531700.0 60463700.0 157890000.0 127178000.0 False True 91727853.38857087 129713295.89979936 102041212.55590242 1.0 1.4141102305132696 1.1124343237777825 26.450856542459004 -10.347258928131458 5.139501126434239 0.9998836834137477 1.2632722771455527 0.5038381853413236 0.1231586731989912 0.00016421783515465296 2.0856479999958934e-05 0.11930032857537642 0.03974929085337788 4.495117742429765e-11 10.347258928131458 0.263388593731805 ACGVSRPVIACSVTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ACGVSRPVIACSVTIK 16 1 P55769;B1AHD1;A0A3B3IUA2;A0A3B3IRU2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 0 146127800.0 51525800.0 45392000.0 49210000.0 False True 70576280.69238839 43386431.348729044 37587611.511763185 1.0 0.6147452220928419 0.5325813593888774 26.07268006757894 -13.999999999999993 0.21716847693951807 3.296352904849648 0.48742129757621055 0.9994952186462991 0.00457787467687093 12.924123708718207 0.1476522512587802 12.708776278375954 0.04633590799130637 1.0000000000000164e-14 13.999999999999993 -2.808931607273437 ACGVSRPVIACSVTIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ACGVSRPVIACSVTIK 16 1 P55769;B1AHD1;A0A3B3IUA2;A0A3B3IRU2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 0 62871800.0 36574000.0 3196800.0 23101000.0 False True 30412901.502922267 3179578.2038848815 27931312.293044142 1.0 0.1045470194147496 0.9184034048957914 24.85818012557175 -8.940966301681314 11.43308168460218 0.9999822403697827 0.5114752121518452 0.3245136511854665 0.33225547821742846 0.0 0.0 0.3217049833825109 0.10723499446083695 1.145601828961792e-09 8.940966301681314 -0.48850702821793746 ACGVSRPVIACSVTIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ACGVSRPVIACSVTIK 16 1 P55769;B1AHD1;A0A3B3IUA2;A0A3B3IRU2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 0 277406100.0 60463700.0 124466700.0 92475700.0 False True 78271451.5677113 117540018.72997738 75646071.48081037 1.0 1.5016971881286183 0.9664580120297149 26.221982864551453 -8.781170612512257 18.650322451595244 1.0000179548205985 1.2340776000791667 0.20319563013923614 0.21851047887755284 0.0 0.0 0.21157186130503794 0.07052395376834597 1.6551196222767387e-09 8.781170612512257 0.23405964525856815 ACINTLQFLYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ACINTLQFLYSR 12 0 E7EXA6;Q8WVB6;Q8WVB6-2;A0A0D9SF58;Q8WVB6-3 E7EXA6 CHTF18 Chromosome transmission fidelity protein 18 homolog 0 10974300.0 3450500.0 3559000.0 3964800.0 False True 4523638.914689537 3028011.072873343 3554560.5290471185 1.0 0.6693750606487474 0.7857745934372554 22.10905234463395 -10.370884003001532 5.001242280692826 1.0001944843803325 0.7275748270429913 0.8795687816122258 0.04751991027185532 0.00010312136757678603 1.2971726617082695e-05 0.046043569082859066 0.015336985091325094 4.2571210265562725e-11 10.370884003001532 -0.2726196573373413 ACLILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ACLILR 6 0 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 0 12423700.0 3667800.0 4042500.0 4713400.0 False True 4808521.3190257205 3439374.757541585 4225702.582125373 1.0 0.715266613029898 0.8787946026995186 22.197161884591598 -10.18654469585792 5.1608004377827115 1.000012863217834 0.7970306082488591 0.6725682842283476 0.06676002222604543 9.881266691646198e-06 1.557523049337338e-06 0.0646442083038964 0.021546704522764012 6.508116284536137e-11 10.18654469585792 -0.20298225496897493 ACLILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ACLILR 6 0 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 0 9730600.0 3667800.0 2151300.0 3911500.0 False True 5023884.778568057 2056248.4526022412 2987684.259871197 1.0 0.40929450877819046 0.5946960154453955 22.26037194611449 -10.5983650538834 7.3203280268887205 1.0005716548887646 0.5019952621117979 0.9058388452723125 0.07568984814631097 0.00070690623228481 3.878486765645722e-05 0.07336367811891671 0.02442879344563589 2.5213605074660656e-11 10.5983650538834 -0.49857639277696675 ACLISLGYDVENDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ACLISLGYDVENDR 14 0 O43707;O43707-2;O43707-3;F5GXS2 O43707 ACTN4 Alpha-actinin-4 0 14276400.0 5669500.0 3290400.0 5316500.0 False True 5489524.825827404 4604273.879209317 3923949.1584187755 1.0 0.8387381467967662 0.7148067060298505 22.388249844038917 -6.974056878617528 0.128470242806052 1.1963521532122625 0.35398884227805544 0.9999992570179873 0.0001004786310351094 0.07500694954998517 0.003851908540894225 0.007930188773226047 0.017064192615105892 1.0615565183120033e-07 6.974056878617528 -0.842363310934207 ACLISLGYDVENDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ACLISLGYDVENDR 14 0 O43707;O43707-2;O43707-3;F5GXS2 O43707 ACTN4 Alpha-actinin-4 0 26413300.0 5334700.0 15111000.0 5967600.0 False True 8093129.918810944 12414323.987218114 4788101.244308 1.0 1.5339336093398641 0.5916254023278396 22.948266324522525 -6.752980221746292 1.6386794260890036 1.312831288196458 0.5893047773918223 0.6617276550424789 0.22440468784462309 0.29488678372506627 1.5588104163601009 0.10813507590982332 0.2617206284487129 1.7661182498440246e-07 6.752980221746292 -0.7235265108046356 ACLISLGYDVENDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ACLISLGYDVENDR 14 0 O43707;O43707-2;O43707-3;F5GXS2 O43707 ACTN4 Alpha-actinin-4 0 14133000.0 2960800.0 3801000.0 7371200.0 False True 4055487.7726114574 3633059.2517738645 5630274.37462931 1.0 0.8958378018815779 1.3883100357626768 21.951444013928707 -6.851435162837499 1.2280638684066087 0.9443365232358649 1.4085574857892111 0.9423747218702266 0.050870232603776475 0.15588922757908966 0.45168285622925586 0.03240007989423441 0.0750514392854052 1.4078773990319383e-07 6.851435162837499 0.4642209625533462 ACLISLGYDVENDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ACLISLGYDVENDR 14 0 O43707;O43707-2;O43707-3;F5GXS2 O43707 ACTN4 Alpha-actinin-4 0 13411700.0 5669500.0 3315900.0 4426300.0 False True 4714440.451435932 3298036.5885453797 5351818.865101139 1.0 0.6995605570838971 1.1351970441096724 22.168655119473193 -6.721147443641918 1.7550872009514578 0.8174387106667125 1.1345656823458379 0.5179253470878598 0.12640899762933777 0.35311639973412895 2.12634272482324 0.05717327719210022 0.1433383573708342 1.9004329704829032e-07 6.721147443641918 0.3171269716791254 ACLISLGYDVENDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ACLISLGYDVENDR 14 0 O43707;O43707-2;O43707-3;F5GXS2 O43707 ACTN4 Alpha-actinin-4 0 21203700.0 5334700.0 10404000.0 5465000.0 False True 6905874.3126581665 9825008.254148984 4470426.075635315 1.0 1.4227030219968197 0.6473367271456445 22.719392646614974 -6.758680258975744 1.6175102639103571 1.2459365929184671 0.6446961639543445 0.6855037911496247 0.17775786228039653 0.2851536101608152 1.47011809323514 0.08672243796861684 0.2086741724927748 1.7430897176384812e-07 6.758680258975744 -0.6012404289641227 ACPLDQAIGLLVAIFHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ACPLDQAIGLLVAIFHK 17 0 R4GN98;P06703 R4GN98 S100A6 Protein S100;Protein S100-A6 0 906190000.0 328320000.0 312460000.0 265410000.0 False True 498085443.407128 256699071.73887715 212951597.16666463 1.0 0.5153715595118386 0.42754029451248393 28.8918180078303 -13.999999999999998 0.24021724798745236 4.211156651269897 0.38878592899535425 0.9995253217128306 0.0054843574216117625 13.631100818358794 0.15512280136657422 20.999798570820687 0.042862999370716436 1.0000000000000041e-14 13.999999999999998 -3.822370722274542 ACPLDQAIGLLVAIFHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ACPLDQAIGLLVAIFHK 17 0 R4GN98;P06703 R4GN98 S100A6 Protein S100;Protein S100-A6 0 573260000.0 328320000.0 107130000.0 137810000.0 False True 425016712.15474653 101168121.32516149 112729994.05000982 1.0 0.23803327829689355 0.26523661499918944 28.662944329922748 -10.41546938339807 5.935246006237163 1.0002539688726668 0.25163494664811986 0.9990099695344935 0.01110571570362656 3.7334448830747307e-05 3.67686009460676e-06 0.010756581522228982 0.00358435433065478 3.841763416309232e-11 10.41546938339807 -0.748619022224547 ACQIFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ACQIFVR 7 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 19879500.0 5033600.0 6646000.0 8199900.0 False True 6894657.947925238 6352357.744616965 6263252.502241547 1.0 0.9213448720147946 0.9084210630240627 22.717047549044175 -13.99999999951706 0.2541414800211174 1.5586332952151463 0.9034255470161494 0.999550606371656 0.0008578993766172624 14.165884654473178 0.15951811959477302 4.049896403606137 0.0058299617738884636 1.0000000011120102e-14 13.99999999951706 -0.6552077481989969 ACQLSVVVDDK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ACQLSVVVDDKK 12 1 P26358;P26358-2;P26358-3;K7ENW7 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 5186500.0 1679200.0 823000.0 2684300.0 True False 2173757.5019805385 777199.3265248559 2195784.943243894 1.0 0.357537271667488 1.0101333480129617 21.051759575833124 -10.938021618246879 11.620205895516552 1.0602159816719399 0.6838353098428566 0.2383570397557988 0.2664212325314643 0.1377886553411288 0.000734918595255353 0.08552075060138364 0.08598708305586786 1.1533958428233923e-11 10.938021618246879 -0.3763806718290833 ACQSIYPLHDVFVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ACQSIYPLHDVFVR 14 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 0 72779000.0 13075000.0 27421000.0 32283000.0 False True 17141451.618480105 23329893.68622086 28942664.840402618 1.0 1.3610220537605477 1.688460550750538 24.030985953014625 -6.972287952523799 0.19598478577796816 0.7947112038363792 2.2637729901251324 0.9999951604716876 0.0006185263456517154 0.0755670818296108 0.0062971411790526816 0.010990631413009266 0.03512302491264438 1.0658891648640285e-07 6.972287952523799 1.4690617862887532 ACQSIYPLHDVFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ACQSIYPLHDVFVR 14 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 0 42687200.0 22026000.0 7300200.0 13361000.0 False True 21326796.68642286 10215207.930040067 9861353.278591791 1.0 0.478984635162922 0.46239261449281605 24.346163951424696 ACQSIYPLHDVFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ACQSIYPLHDVFVR 14 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 0 80798000.0 13075000.0 36244000.0 31479000.0 False True 17909180.838589177 34642620.23711966 24044308.530355446 1.0 1.9343497923966848 1.342568861583374 24.094196014537516 -10.102076863470701 4.3798514924416185 0.9999335635526637 1.6384593270166985 0.6081458371704098 0.24159355354081535 56068190.88703282 6.391066459043601 42145.36753679041 0.08270389935762011 7.905387023771276e-11 10.102076863470701 0.6385257634640348 ACQSIYPLHDVFVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ACQSIYPLHDVFVR 14 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 0 31333500.0 22026000.0 4178800.0 5128700.0 False True 18315594.91724629 4156287.97497314 6201087.457570481 1.0 0.22692617923426037 0.3385687161999541 24.126569226858972 -10.81413515069777 7.4032754502420195 1.03017612184645 0.28274744771713667 0.9821533881340546 0.045577874859293106 0.01870536502821914 0.00046961183100604256 0.036363243621937415 0.014710195857130645 1.534139490461054e-11 10.81413515069777 -0.7474286741293134 ACTILLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ACTILLR 7 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 41974000.0 10278000.0 14036000.0 17660000.0 False True 13474557.53229359 11941883.511899486 15832712.60668184 1.0 0.8862542226918514 1.1750079784613792 23.683734563798115 -6.799894781792162 1.456831854803978 0.9372327007852046 1.1789611855000093 0.8317093763524337 0.048720962866507955 0.2209168091574109 0.9257427516015467 0.026312386719013668 0.06118347205378631 1.5852772171969938e-07 6.799894781792162 0.24172848471480468 ACTILLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ACTILLR 7 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 46288000.0 10278000.0 15091000.0 20919000.0 False True 14078054.35250629 14424229.720736498 15978363.040328657 1.0 1.0245897167010567 1.1349837584256848 23.746944625321007 -6.942232975877167 0.6384476923270407 0.9987926815682941 1.1668172229626068 0.9984420355918654 0.002316977671260201 0.08676243725729167 0.050079515247423136 0.0022955796183418567 0.00941188457229293 1.1422654058016837e-07 6.942232975877167 0.16802454139431267 ACVMMQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ACVMMQGR 8 0 P00491;G3V5M2;G3V2H3 P00491 PNP Purine nucleoside phosphorylase 0 2298620.0 750920.0 707110.0 840590.0 False True 984463.3919196242 601611.9442931918 753613.810308645 1.0 0.6111064659500411 0.7655071955892223 19.908978033760214 -10.252096694801647 5.074494317752729 1.0000499453868363 0.6883068307694968 0.8445681266067759 0.06303383392204359 3.5623289117165465e-05 5.250320068540189e-06 0.061042005602242606 0.02034408241890516 5.5963298645286294e-11 10.252096694801647 -0.3117431146173395 ACVVHGSDLK(ub)DMTSEQLDDILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ACVVHGSDLKDMTSEQLDDILK 22 1 P05023-4;P05023;P05023-3 P05023-4 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 1 17691300.0 3995800.0 10312000.0 3383500.0 True False 3868955.5161903426 14429635.3763696 2497259.8471757597 1.0 3.729594541985863 0.645460987267888 21.883512710630367 -6.673120093569995 1.9261899396995759 2.737599459256501 0.6577152524899107 0.29295549918365327 1.1586468703233157 0.454016687911486 3.250422338908346 0.48373530966877604 1.2872418543510546 2.1226574115864487e-07 6.673120093569995 -2.0798842067665904 ACYLSINPQK(ub)DETLETEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ACYLSINPQKDETLETEK 18 1 P61163;R4GMT0 P61163 ACTR1A Alpha-centractin 1 8127400.0 2910100.0 1907300.0 3310000.0 True False 3986042.6124954754 1823029.1794023404 2528246.171589841 1.0 0.45735315866606524 0.6342747475062802 21.926525702608846 -10.41312740953666 7.00244340678729 1.0000352932527556 0.5458139530861738 0.8978244931429975 0.07222793619016822 3.979992687284333e-05 3.335648221654183e-06 0.06993980999518087 0.02331146616628779 3.862536446968472e-11 10.41312740953666 -0.4542213401665819 ACYLSINPQK(ub)DETLETEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ACYLSINPQKDETLETEK 18 1 P61163;R4GMT0 P61163 ACTR1A Alpha-centractin 1 21680600.0 7604000.0 4421800.0 9654800.0 True False 9843527.897248706 4175722.9429254103 7897725.466613702 1.0 0.4242099973214417 0.8023267215833398 23.230744036076885 -10.156582062610566 5.588917852334941 1.0000074750810672 0.613268359452375 0.5824254786242096 0.15436550627585557 1.4378179701175166e-05 2.1697169311306814e-06 0.14946664715215827 0.04982125291958511 6.972972258377882e-11 10.156582062610566 -0.38673911562869223 ADADCK(ub)FAHPPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADADCKFAHPPR 12 1 B1AKI6;Q9NUK0-2;Q9NUK0 B1AKI6 MBNL3 Muscleblind-like protein 3 1 3248630.0 372230.0 1812700.0 1063700.0 True False 487997.134680447 1542252.2258492566 953638.5277308882 1.0 3.160371478121819 1.9541887850537383 18.896513151334716 -10.332997043149728 5.9121641117772175 0.9998226072836618 2.5572801315877816 0.6896840267338367 0.4924220224321525 0.0011515116634945946 0.0001299123664872729 0.47683706430693573 0.1589285243487904 4.6451843783901744e-11 10.332997043149728 1.5574575243041198 ADADCK(ub)FAHPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADADCKFAHPPR 12 1 B1AKI6;Q9NUK0-2;Q9NUK0 B1AKI6 MBNL3 Muscleblind-like protein 3 1 3361830.0 372230.0 1715700.0 1273900.0 True False 509853.49013751774 1639894.7009388106 973031.0567940484 1.0 3.2164037957188407 1.9084522821087335 18.959723212857607 -10.19980071915132 5.539561765452365 0.9999423197206448 2.562428038913898 0.6554854539105921 0.5339689694413641 0.00038041378751477845 5.495082546155939e-05 0.5170320295671591 0.17233774383643485 6.312469327038906e-11 10.19980071915132 1.562485719193253 ADAGK(ub)EGNNPAENGDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADAGKEGNNPAENGDAK 17 1 P05204 P05204 HMGN2 Non-histone chromosomal protein HMG-17 1 33663400.0 14258000.0 13938000.0 5467400.0 True False 18692376.074668404 11858504.729898471 4901685.895004096 1.0 0.6344032819866555 0.26222915029228305 24.155946632612974 -7.478176673333773 0.3191049034597145 1.0742843486985203 3.3082759481097964e-12 0.9996350418826697 0.005754040505214671 0.12153947084036118 0.032846152416768054 0.020560860222505598 0.06363634180033588 3.325242531187466e-08 7.478176673333773 -1.074284348695212 down ADAGK(ub)EGNNPAENGDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADAGKEGNNPAENGDAK 17 1 P05204 P05204 HMGN2 Non-histone chromosomal protein HMG-17 1 36820000.0 16908000.0 14460000.0 5452000.0 True False 16371264.794971269 20233953.40790384 4023957.64350591 1.0 1.235943200559499 0.24579393797001814 23.964662448634783 -6.843840712524618 1.2645141543538612 1.1255214446662734 0.21068764036711582 0.930843384007754 0.11104997256921671 0.1643641274175462 0.5088692639950735 0.06881635390787726 0.1587345213645565 1.4327132834201418e-07 6.843840712524618 -0.9148338042991575 down ADAGK(ub)EGNNPAENGDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADAGKEGNNPAENGDAK 17 1 P05204 P05204 HMGN2 Non-histone chromosomal protein HMG-17 1 34551600.0 16324000.0 10871000.0 7356600.0 True False 24764701.444255497 8930985.114489323 5902564.78548767 1.0 0.36063366782727696 0.23834588915897667 24.561781892593984 -13.999999999999998 0.23258269881578536 5.084971894181553 0.1803310044442318 0.9995134278171399 0.007366970881544415 13.373127663741359 0.15268299028990492 25.26441841727544 0.06247422854102042 1.0000000000000041e-14 13.999999999999998 -4.904640889737322 ADAGK(ub)EGNNPAENGDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADAGKEGNNPAENGDAK 17 1 P05204 P05204 HMGN2 Non-histone chromosomal protein HMG-17 1 35466000.0 14258000.0 14480000.0 6728000.0 True False 19529567.907962106 13840225.721043292 5138984.967509497 1.0 0.7086805906955423 0.2631386926596752 24.219156694135865 -7.131686568882452 0.39562270425208046 1.0289427843267194 3.570661261399172e-11 0.9997995169414681 0.00429038594126278 0.07963303761038257 0.020870086180458918 0.007260135816783537 0.03880541628576436 7.384369691704385e-08 7.131686568882452 -1.0289427842910128 down ADAGK(ub)EGNNPAENGDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADAGKEGNNPAENGDAK 17 1 P05204 P05204 HMGN2 Non-histone chromosomal protein HMG-17 1 35537900.0 16908000.0 15912000.0 2717900.0 True False 14059751.151402878 15826278.89771529 3286200.3238502527 1.0 1.1256443110044767 0.23373104462964528 23.74506772406906 -6.871222104109902 1.1275446747376447 1.0716208783938739 0.18025350139866028 0.9658910596078522 0.07280119109194838 0.13569187024432913 0.3216695094356885 0.0500682974268317 0.11880273093090443 1.3451722387210597e-07 6.871222104109902 -0.8913673769952136 down ADAGK(ub)EGNNPAENGDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADAGKEGNNPAENGDAK 17 1 P05204 P05204 HMGN2 Non-histone chromosomal protein HMG-17 1 34956900.0 16324000.0 14905000.0 3727900.0 True False 21131739.794146225 14075523.647452004 3049460.451484158 1.0 0.6660844674677999 0.1443071172175279 24.332908214686434 -7.395349999898033 0.49766743860416085 1.0128891726111007 8.582806648804608e-28 0.9979348501092873 0.016002178537787345 0.10957206560952616 0.057832483059405755 0.017919530386107038 0.06264471450318217 4.023926135796715e-08 7.395349999898033 -1.0128891726111007 down ADALQAGASQFETSAAK(ub)LK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADALQAGASQFETSAAKLK 19 1 K7ENK9;K7EKX0;J3QRU4;F8WCA0;L7N2F9;Q15836;P63027 K7ENK9 VAMP2;VAMP3 Vesicle-associated membrane protein 3;Vesicle-associated membrane protein 2 1 38728000.0 11900000.0 15606000.0 11222000.0 True False 15601015.239763945 13277645.631711539 10060855.089025127 1.0 0.851075742677913 0.6448846395189698 23.89513658007563 -6.966554431874584 0.3302938365555688 1.025034737121141 0.46417278965262077 0.999941688417742 0.0011118331800939794 0.07743743356500006 0.013021440088113114 0.003005512232421469 0.01798018700785508 1.080054244854891e-07 6.966554431874584 -0.5608619474685202 ADALQAGASQFETSAAK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADALQAGASQFETSAAKLK 19 1 K7ENK9;K7EKX0;J3QRU4;F8WCA0;L7N2F9;Q15836;P63027 K7ENK9 VAMP2;VAMP3 Vesicle-associated membrane protein 3;Vesicle-associated membrane protein 2 1 46207000.0 11261000.0 12262000.0 22684000.0 True False 10903525.718959756 17158280.545485266 16742379.894586932 1.0 1.573645166503284 1.535501481458809 23.37829137855221 -10.174387166422871 4.897927673216142 0.9999498641500558 1.5545733239824968 0.9964645027768085 0.015572094216468081 8.526414499912217e-06 1.4372215485305266e-06 0.015078973433462078 0.005025871796439946 6.692876843646801e-11 10.174387166422871 0.554623459832441 ADALQAGASQFETSAAK(ub)LK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADALQAGASQFETSAAKLK 19 1 K7ENK9;K7EKX0;J3QRU4;F8WCA0;L7N2F9;Q15836;P63027 K7ENK9 VAMP2;VAMP3 Vesicle-associated membrane protein 3;Vesicle-associated membrane protein 2 1 58171000.0 15970000.0 19150000.0 23051000.0 True False 24227657.56338888 15732532.880367087 18494959.74638781 1.0 0.6493625245942463 0.7633820850405316 24.530151589634478 -10.787648664955581 10.277449941642855 1.0019291535665487 0.706372304817389 0.8983995800844111 0.04654829063163709 0.0020668002086678323 4.2703839058017714e-05 0.045272014460590274 0.0150233962008961 1.6306146319351336e-11 10.787648664955581 -0.29555684874915966 ADALQAGASQFETSAAK(ub)LK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADALQAGASQFETSAAKLK 19 1 K7ENK9;K7EKX0;J3QRU4;F8WCA0;L7N2F9;Q15836;P63027 K7ENK9 VAMP2;VAMP3 Vesicle-associated membrane protein 3;Vesicle-associated membrane protein 2 1 44835000.0 11900000.0 13424000.0 19511000.0 True False 16299751.58540815 12830883.292768305 14902903.641658403 1.0 0.7871827509478585 0.9143025010884073 23.95834664159852 -10.250703270653531 5.124782979749054 1.0000215750571777 0.85074262605852 0.6476595467620472 0.05189642067925048 1.279472423259381e-05 1.8706958039119051e-06 0.0502557538597044 0.016749497751517045 5.614314400004298e-11 10.250703270653531 -0.14927894899865768 ADALQAGASQFETSAAK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADALQAGASQFETSAAKLK 19 1 K7ENK9;K7EKX0;J3QRU4;F8WCA0;L7N2F9;Q15836;P63027 K7ENK9 VAMP2;VAMP3 Vesicle-associated membrane protein 3;Vesicle-associated membrane protein 2 1 44745000.0 11261000.0 17564000.0 15920000.0 True False 9364020.446885966 17469379.24581897 19248798.39423673 1.0 1.8655853375062275 2.055612597539551 23.158696653986485 -10.84258313115309 0.29587882672474314 6.102178692260011e-10 2.11561783139325 0.9991937779460534 0.013045018462185561 2.6133856448537114 0.1496026654244028 1.897752778058007 0.06951781170966777 1.4368679867126968e-11 10.84258313115309 2.1156178307830324 ADALQAGASQFETSAAK(ub)LK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADALQAGASQFETSAAKLK 19 1 K7ENK9;K7EKX0;J3QRU4;F8WCA0;L7N2F9;Q15836;P63027 K7ENK9 VAMP2;VAMP3 Vesicle-associated membrane protein 3;Vesicle-associated membrane protein 2 1 53430000.0 15970000.0 16276000.0 21184000.0 True False 20673479.81576299 15370226.292246137 17328729.366195556 1.0 0.7434755265790687 0.8382105731896597 24.301277911726928 -10.35036049717506 4.856939081621153 1.0001462893836635 0.7908430498842691 0.8666529963499814 0.03867542082611638 6.13076584430833e-05 8.200201840898761e-06 0.03747340560515616 0.012482438397212617 4.463129649255496e-11 10.35036049717506 -0.20930323949939433 ADDADEFGYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADDADEFGYSR 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 13571290.0 288690.0 7886900.0 5395700.0 False True 378475.3856779368 6710205.262895412 4837404.723209124 1.0 17.72956846553148 12.781292803346288 18.52983995135829 -9.986329314665028 9.71367086322965 1.0000000003606198 15.255430634218472 0.9171226648012428 2.020125079831044 7.00469725167207e-08 0.0 1.9559776978603878 0.6519925659534633 1.0319785854006604e-10 9.986329314665028 14.255430633857852 ADDADEFGYSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADDADEFGYSR 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 8734530.0 2219600.0 691730.0 5823200.0 False True 2149140.012947611 967941.3963242966 4297929.227744611 1.0 0.45038545208449937 1.999836772779578 21.03532804436776 -6.810848179524688 1.4112661160068907 0.7007710570403106 2.02739347475058 0.861954973720549 0.23830850456485347 0.20564990557579316 0.8071470449735477 0.13277960402709482 0.3069868891230648 1.5457947233411079e-07 6.810848179524688 1.3266224177102695 ADDADEFGYSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADDADEFGYSR 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 12809090.0 288690.0 6430200.0 6090200.0 False True 395426.4945539053 6146092.502172143 4651820.1916061705 1.0 15.54294562155166 11.764057936618675 18.593050012881182 -9.681300793555096 8.24332335792652 0.9999941836124746 13.653501779085207 0.937302862377663 1.5427244372325615 0.0 0.0 1.493736513295547 0.49791217109851554 2.0830476588149828e-10 9.681300793555096 12.653507595472732 ADDGRPFPQVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADDGRPFPQVIK 12 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 106987800.0 1719800.0 66891000.0 38377000.0 False True 2254674.4545668927 56911123.53907588 34406116.178178325 1.0 25.241392797883147 15.259904199689663 21.10448771159114 -9.543856114748905 10.703347645910615 1.00000007160883 20.25064849875826 0.8322009903598038 4.07492565649703 0.0 0.0 3.945530095126459 1.3151766003871934 2.858537442929681e-10 9.543856114748905 19.25064842714943 ADDGRPFPQVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADDGRPFPQVIK 12 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 95065000.0 26583000.0 10381000.0 58101000.0 False True 25739137.215798516 14526187.436199853 42882605.10736188 1.0 0.5643618631973325 1.6660467189646442 24.617460358976423 -6.799420238584231 1.458234917557482 0.7594600729231205 1.6810447104548756 0.8304688534674474 0.18653042477998266 0.22158995148916674 0.9303171232562784 0.10063213171231589 0.23412092271311344 1.5870103584589489e-07 6.799420238584231 0.9215846375317551 ADDGRPFPQVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADDGRPFPQVIK 12 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 141805800.0 1719800.0 75854000.0 64232000.0 False True 2355656.5358474725 72502519.4643659 49061724.49956454 1.0 30.778052046658978 20.82719774846721 21.167697773114032 -9.400254103689848 10.370046933962872 0.9999999998689741 25.802624897563103 0.8922818764615977 4.062419255891803 0.0 8.786399852901434e-17 3.9334205308453067 1.3111401769484352 3.978743080219492e-10 9.400254103689848 24.80262489769413 ADDGRPFPQVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADDGRPFPQVIK 12 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 9451400.0 1831000.0 3953700.0 3666700.0 False True 2370265.594405892 3733673.119418376 2999398.223519129 1.0 1.5752129753856647 1.2654270604096287 21.17661729522567 -10.126896536247244 4.501893683608441 0.9999562890274597 1.4203200179032809 0.7105284318379366 0.1264695702857524 88268185.87701389 4.266666304187601 45120.08875773403 0.04329389778877594 7.466266091385239e-11 10.126896536247244 0.4203637288758212 ADDGRPFPQVIK(ub)SK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADDGRPFPQVIKSK 14 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 12125300.0 4247000.0 3219500.0 4658800.0 True False 5567858.128006498 2739163.1495127063 4176752.066365195 1.0 0.4919599398078466 0.7501541832317895 22.40869102034036 -10.276023750852156 4.921310386272012 1.0001036711758104 0.6210570615195653 0.7417394303750305 0.1054073584864093 0.00011993160333524137 1.7643148730275156e-05 0.1020880140794292 0.03402007866532583 5.296344782596038e-11 10.276023750852156 -0.37904660965624515 ADDGRPFPQVIK(ub)SK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADDGRPFPQVIKSK 14 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 26357100.0 4810600.0 4871500.0 16675000.0 True False 4657890.136189309 6816715.354536891 12307317.26072286 1.0 1.4634770583304806 2.642251513212303 22.151245180997453 -6.955092362378785 0.4998234300799243 0.9763566458611075 3.180198128871738 0.9995426809503795 0.014783890660047838 0.0815030835015045 0.027981447395046256 0.017343449956525574 0.09723763433950486 1.1089389496556426e-07 6.955092362378785 2.2038414830106303 ADDGRPFPQVIK(ub)SK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADDGRPFPQVIKSK 14 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 121420000.0 15347000.0 23073000.0 83000000.0 True False 23282521.015988067 18955442.8798282 66595013.619807616 1.0 0.8141490720361223 2.860300805659187 24.472743944981264 -6.884714133845076 1.0531829218102087 0.8757261871388409 3.0190687391539286 0.977292265676662 0.13922034371451855 0.12353519137294465 0.24775987763034876 0.10135949441358368 0.24832346779124434 1.304024845787849e-07 6.884714133845076 2.1433425520150875 up ADDGRPFPQVIK(ub)SK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADDGRPFPQVIKSK 14 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 13690200.0 4247000.0 3368200.0 6075000.0 True False 5817230.6708595175 3219381.786852074 4640210.118552355 1.0 0.5534217171375118 0.7976665154085676 22.47190108186325 -10.112134948105881 5.236409408281156 1.000007276637543 0.6755441162727095 0.7017487604637516 0.09971252135000333 8.470836718518847e-06 1.436130246371697e-06 0.09654839808941532 0.032182077882910005 7.724405277445897e-11 10.112134948105881 -0.32446316036483347 ADDGRPFPQVIK(ub)SK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADDGRPFPQVIKSK 14 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 22742200.0 4810600.0 7954500.0 9977100.0 True False 4000227.0457143798 7911647.529655369 12063265.481101716 1.0 1.9777996196819545 3.015645197945858 21.93165045643173 -6.9703696639387696 0.24919813070174682 0.6673704198216991 4.356440575090779 0.9999851242186958 0.0031742553684540246 0.07618293610610966 0.008599859892164413 0.02327415997724631 0.09959849389344762 1.0706076346234032e-07 6.9703696639387696 3.6890701552690794 ADDGRPFPQVIK(ub)SK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADDGRPFPQVIKSK 14 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 86328000.0 15347000.0 17137000.0 53844000.0 True False 19866994.03459705 16183310.885366306 44044944.48609486 1.0 0.8145827626053617 2.216990874884923 24.243870267073714 -6.873605866095191 1.114892175821627 0.892469633517683 2.304935901623356 0.9681490343079072 0.11101114486843333 0.13344209898752363 0.30782818870828105 0.07709569079397433 0.1837530290033324 1.3378090634503654e-07 6.873605866095191 1.412466268105673 up ADDLGK(ub)GGNEESTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADDLGKGGNEESTK 14 1 P00441;H7BYH4 P00441 SOD1 Superoxide dismutase [Cu-Zn] 1 3009310.0 864590.0 1286200.0 858520.0 True False 1133485.8627014707 1094303.9735683312 769688.5859053513 1.0 0.9654323971542476 0.679045598390552 20.112334966633423 -6.929450659829963 0.7512877138797887 1.0044450324497742 0.6210660125696119 0.9964291564589238 0.00859571360518898 0.09292415358018233 0.07908502007362557 0.007805660920775118 0.025991805349451058 1.1763846260798845e-07 6.929450659829963 -0.3833790198801623 ADDLGK(ub)GGNEESTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADDLGKGGNEESTK 14 1 P00441;H7BYH4 P00441 SOD1 Superoxide dismutase [Cu-Zn] 1 2748480.0 977860.0 735920.0 1034700.0 True False 946818.3695535015 1029776.6937721004 763681.0296653631 1.0 1.0876179918834066 0.8065760595936665 19.852728171010664 -6.822935291901253 1.3590524664629595 1.0470911909437488 0.8000419868436733 0.8910145958604786 0.038761790410986235 0.1896959760732764 0.68763639032878 0.022407510560223786 0.051611642681926986 1.5033659447709947e-07 6.822935291901253 -0.24704920410007547 ADDLGK(ub)GGNEESTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADDLGKGGNEESTK 14 1 P00441;H7BYH4 P00441 SOD1 Superoxide dismutase [Cu-Zn] 1 3389620.0 863790.0 704130.0 1821700.0 True False 1310432.5815078085 578472.5001071997 1461640.1965205248 1.0 0.44143629231318277 1.115387557625234 20.321611701833458 -6.686646517246544 1.8780435122334203 0.6487158886968121 1.1129827012276912 0.3547866727109138 0.23639783090462704 0.4239853104247458 2.8965760620154897 0.10079032493395249 0.2636078545273843 2.057564616095957e-07 6.686646517246544 0.4642668125308791 ADDLGK(ub)GGNEESTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADDLGKGGNEESTK 14 1 P00441;H7BYH4 P00441 SOD1 Superoxide dismutase [Cu-Zn] 1 2879890.0 864590.0 1127200.0 888100.0 True False 1184252.2876662205 1077396.5768480678 678349.0709936367 1.0 0.909769470634732 0.5728079042434818 20.175545028156314 -6.946454291086212 0.5965020230524445 1.0038264722906272 0.46160502702447476 0.9988928392845837 0.006117128375614222 0.08494154111217059 0.04210114711197462 0.006300114691491578 0.02828559132024904 1.1312164420871886e-07 6.946454291086212 -0.5422214452661525 ADDLGK(ub)GGNEESTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADDLGKGGNEESTK 14 1 P00441;H7BYH4 P00441 SOD1 Superoxide dismutase [Cu-Zn] 1 2813300.0 977860.0 1209500.0 625940.0 True False 813133.9165431049 1202984.183433048 756821.1599804368 1.0 1.4794416503339605 0.9307460242193908 19.63313344644494 -6.675828485478769 1.9168147714945387 1.3044819544604853 0.9329035551851741 0.30505925128112843 0.20338762401724847 0.4478777178500795 3.1778524183595778 0.08525809478209201 0.22606263563864587 2.1094610681183987e-07 6.675828485478769 -0.3715783992753112 ADDLGK(ub)GGNEESTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADDLGKGGNEESTK 14 1 P00441;H7BYH4 P00441 SOD1 Superoxide dismutase [Cu-Zn] 1 3389460.0 863790.0 742770.0 1782900.0 True False 1118193.1828464577 701434.1965526949 1458430.494098851 1.0 0.6272924994651938 1.3042741777286548 20.092738023925907 -6.757256325172956 1.622990925908802 0.7827731428371036 1.306401616862613 0.6796040514447259 0.15670511439685514 0.2875453551937651 1.4921888438701747 0.0762081403225233 0.18362569891367392 1.7488142154150282e-07 6.757256325172956 0.5236284740255093 ADDYEQVK(ub)NVADYYPEYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADDYEQVKNVADYYPEYK 18 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 147684800.0 3910800.0 36764000.0 107010000.0 True False 5932969.517777158 30203176.961556923 85859426.59585083 1.0 5.090735233184347 14.471577232714125 22.50032293990824 -6.957284849549807 0.47215375910346996 0.757341406050783 19.190932247516695 0.9996558383281556 0.10461844079747 0.08068579011962479 0.024826843884283082 0.1302360557065446 0.7741387387344947 1.1033547028459359e-07 6.957284849549807 18.43359084146591 ADDYEQVK(ub)NVADYYPEYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADDYEQVKNVADYYPEYK 18 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 170692800.0 3910800.0 18392000.0 148390000.0 True False 5062607.693392979 17368469.03213264 121384542.60997708 1.0 3.4307357164568733 23.9766835515206 22.27144926200069 -6.929086360404436 0.7542519037362545 0.6767383622642472 28.098200289117234 0.9963556537471606 0.6221731237423157 0.09311498662075948 0.08002410140035598 0.5637797703197638 1.8684806401520695 1.1773718272869502e-07 6.929086360404436 27.421461926852988 ADDYIEITGAGGK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADDYIEITGAGGKK 14 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 10371600.0 1775000.0 1819900.0 6776700.0 True False 2297772.490480859 1718620.965179327 5543410.134813878 1.0 0.7479508838665172 2.4125147976046133 21.13180452870774 -6.868308448547644 1.142946832122779 0.8587971063549175 2.506941014845436 0.9629687402241508 0.14096589919630637 0.13849027445340537 0.33917322991097865 0.09580972174559212 0.22620074456068803 1.3542272592072602e-07 6.868308448547644 1.6481439084905185 up ADEASELACPTPK(ub)EDGLAQQQTQLNLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADEASELACPTPKEDGLAQQQTQLNLR 27 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 8876500.0 1963600.0 3275700.0 3637200.0 True False 2574298.61552945 2786978.328578594 3260857.434486022 1.0 1.0826165666120295 1.266697427724549 21.295747983471646 -6.957878772272138 0.464366352748934 0.9948620429353505 1.3619271622281255 0.9996832451545411 0.001983968388047107 0.08046778076322043 0.023998558693497093 0.002519101723179272 0.015200222833080658 1.101846833013461e-07 6.957878772272138 0.36706511929277497 ADEASELACPTPK(ub)EDGLAQQQTQLNLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADEASELACPTPKEDGLAQQQTQLNLR 27 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 29356900.0 4594000.0 7929900.0 16833000.0 True False 6969433.866387515 6514747.388408508 13505950.171834005 1.0 0.9347599121110987 1.9378833963790203 22.73261003871381 -6.8913720819115625 1.0142658602976362 0.9478602890213556 2.026505327393472 0.981760841272632 0.06189106148650112 0.11803558231444744 0.21541849721657808 0.046410215619201965 0.11628386814625646 1.2841859618387833e-07 6.8913720819115625 1.0786450383721164 ADEASELACPTPK(ub)EDGLAQQQTQLNLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADEASELACPTPKEDGLAQQQTQLNLR 27 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 10928100.0 1963600.0 3817500.0 5147000.0 True False 2689595.984294741 3648830.22721566 3931384.6057924205 1.0 1.356646220667394 1.461700801439625 21.358958044994537 -12.37637494938663 0.19535368954558055 1.7595267539301148e-08 1.5390745906726595 0.9994289739786663 0.004721800493210862 6.276314274508343 0.12746830027750924 2.5477744572525673 0.06897103735057564 4.2036354959817437e-13 12.37637494938663 1.539074573077392 ADEASELACPTPK(ub)EDGLAQQQTQLNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADEASELACPTPKEDGLAQQQTQLNLR 27 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 28657400.0 4594000.0 7639400.0 16424000.0 True False 5947023.561278352 7214260.67442769 13435000.524471074 1.0 1.2130876227564393 2.259113384373936 22.503736360806258 -6.940217304151717 0.6575489437640645 0.988301056034495 2.542996045886392 0.9981921007404702 0.023396157493264274 0.08766783044533238 0.05416136436855927 0.022811934581242387 0.08994359825332049 1.1475792735605075e-07 6.940217304151717 1.554694989851897 up ADEDPIMGFHQMFLLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ADEDPIMGFHQMFLLK 16 0 P61970;H3BRV9 P61970 NUTF2 Nuclear transport factor 2 0 16832650.0 3786300.0 7756150.0 5290200.0 False True 4963875.966581354 6598962.653235911 4742820.851181662 1.0 1.3293971681932757 0.9554672363113187 22.243035636316698 -6.674154925543369 1.923189388061633 1.2095023263447267 0.9569656190019888 0.2973944954439237 0.13978899201817235 0.4516154121690672 3.2243113047378698 0.05844229479530349 0.15527121032989555 2.1176055886473154e-07 6.674154925543369 -0.2525367073427378 ADEDPIMGFHQMFLLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ADEDPIMGFHQMFLLK 16 0 P61970;H3BRV9 P61970 NUTF2 Nuclear transport factor 2 0 27940400.0 13161700.0 5481300.0 9297400.0 False True 12743889.037850324 7670011.674601887 6862132.023978686 1.0 0.6018580083223706 0.5384645145290915 23.60330227457095 -13.999999999999998 0.25861712546213905 3.8936967616022917 0.5149858682280718 0.9995595244021305 0.0042871987313588935 14.356429088237094 0.1609245744568861 21.692988449606503 0.027918164723701046 1.0000000000000041e-14 13.999999999999998 -3.37871089337422 ADEDPIMGFHQMFLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADEDPIMGFHQMFLLK 16 0 P61970;H3BRV9 P61970 NUTF2 Nuclear transport factor 2 0 39548400.0 4170900.0 29693000.0 5684500.0 False True 6327560.233634236 24394052.157532122 4560956.083395144 1.0 3.8552066289097007 0.7208080073503398 22.593217905101746 -6.667002512205874 1.9482615143958133 2.8271795881347423 0.733705383996726 0.2657171544349758 1.2136807550761441 0.46804258841609825 3.422173552510254 0.5020635503040034 1.3465243178229243 2.1527692818484944e-07 6.667002512205874 -2.0934742041380163 ADEDPIMGFHQMFLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 3 ADEDPIMGFHQMFLLK 16 0 P61970;H3BRV9 P61970 NUTF2 Nuclear transport factor 2 0 23321060.0 4407410.0 8467450.0 10446200.0 False True 6036948.582776779 8093330.060887287 7979022.706242236 1.0 1.340632597729472 1.321697973212184 22.525388082966305 -10.14444055470452 5.320199412823215 0.999990703995815 1.3311652854709786 0.997554195223342 0.007730028090285326 8.523635383554193e-07 1.370655121531882e-07 0.007484777429893524 0.0024948558382064147 7.170665193877662e-11 10.14444055470452 0.33117458147516354 ADEDPIMGFHQMFLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADEDPIMGFHQMFLLK 16 0 P61970;H3BRV9 P61970 NUTF2 Nuclear transport factor 2 0 15559800.0 9724300.0 2781000.0 3054500.0 False True 8086186.309533184 2766018.201014723 3693181.8275876995 1.0 0.3420670876397857 0.4567272736758037 22.947028013688552 -9.946180325798279 5.871404506245287 1.0000003901088306 0.3993971806605018 0.9733927536912644 0.046809824934390516 2.390174843840467e-07 4.290522320228768e-08 0.04532344781709907 0.015107806034014177 1.1319302706598131e-10 9.946180325798279 -0.6006032094483288 ADEGISFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADEGISFR 8 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 66553500.0 3737500.0 28605000.0 34211000.0 False True 4899898.694001481 24337245.50141669 30671173.89508447 1.0 4.966887485084265 6.259552658227918 22.224320490965788 -9.185350382316583 0.3977846288396223 1.8968045539228975e-18 6.4708866786563775 0.997849077065882 0.10378517071183953 0.5913950224499385 0.15283121170652889 1.2797154055605966 0.3265038197671767 6.526038291547888e-10 9.185350382316583 6.4708866786563775 ADEGISFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADEGISFR 8 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 62070400.0 18761000.0 5873400.0 37436000.0 False True 18165442.32425221 8218679.249376368 27630388.544073183 1.0 0.4524348541958608 1.5210413295130485 24.114693159677888 -6.767416491485096 1.5842766179022851 0.684893996122447 1.5264819515127497 0.7205921959313257 0.23062481279745206 0.2706349065447337 1.3401586882558618 0.11476832357980274 0.27385625205687564 1.7083761843823643e-07 6.767416491485096 0.8415879553903027 ADEGISFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADEGISFR 8 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 52974500.0 3737500.0 26076000.0 23161000.0 False True 5119354.752139733 24923876.09819923 17690848.81576804 1.0 4.868558110332521 3.455679411233185 22.28753055248868 -9.468172711258047 11.63090995792521 1.0000000000000122 4.162118760783146 0.8697679008406367 0.5768053135401108 0.0 0.0 0.5584893433361992 0.18616311444539968 3.402728422804007e-10 9.468172711258047 3.162118760783134 ADEGISFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADEGISFR 8 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 22259200.0 18761000.0 2003000.0 1495200.0 False True 15600602.753221538 1992209.441435631 1807839.406976307 1.0 0.1277007993184262 0.1158826639953374 23.895098435112164 ADFCIIHYAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADFCIIHYAGK 11 0 P35579;P35579-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 56314000.0 16434000.0 18285000.0 21595000.0 False True 21545133.147082377 15556949.274371756 19360556.553867172 1.0 0.7220632691461675 0.8986046371446519 24.360858678419493 -10.749109446818068 5.4572028378598825 1.0081064172400338 0.8103339531454348 0.6061366333255482 0.07207271168153309 0.007336618667521234 0.0003372948592952817 0.07202459256231022 0.023261367671548842 1.7819296456786227e-11 10.749109446818068 -0.19777246409459903 ADFCIIHYAGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADFCIIHYAGK 11 0 P35579;P35579-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 27293100.0 6839700.0 14124000.0 6329400.0 False True 10376324.949048897 11603461.848684305 5078391.315725429 1.0 1.1182631524803865 0.48942099834594316 23.306792229623184 -6.8580738839965845 1.1954854484875514 1.0638630425102023 0.4600794917071627 0.9512471075763624 0.06024972641898822 0.14880244285973923 0.4052159800313681 0.03933794013877337 0.09163318799066773 1.3865199282277298e-07 6.8580738839965845 -0.6037835508030396 down ADFCIIHYAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADFCIIHYAGK 11 0 P35579;P35579-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 48534000.0 16434000.0 12290000.0 19810000.0 False True 22510093.91215102 11746987.162404852 15131285.999756722 1.0 0.5218542049735204 0.6722000387385682 24.424068739942385 -10.908651719771262 11.287051630779269 1.0375165644941025 0.5970271218560443 0.9054706234739089 0.061378429612944874 0.03248279593744386 0.0002628890456870871 0.03331450611062071 0.019809802975608286 1.2340941119357753e-11 10.908651719771262 -0.4404894426380581 ADFCIIHYAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADFCIIHYAGK 11 0 P35579;P35579-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 12964600.0 5411500.0 1790100.0 5763000.0 False True 4499902.02009799 1780456.3759929705 6968016.654898642 1.0 0.3956655873929894 1.5484818611110351 22.1014621581759 -6.76427614308664 1.5964566896212815 0.6508328371591324 1.5535927241838599 0.7081193127442871 0.2543647867281367 0.27580680583749645 1.3863227194401353 0.12566035154093128 0.3007105501515194 1.7207740849822116e-07 6.76427614308664 0.9027598870247274 ADFCIIHYAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADFCIIHYAGK 11 0 P35579;P35579-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 20375700.0 6839700.0 9619000.0 3917000.0 False True 8854126.480643338 9083694.194219435 3204146.1918140035 1.0 1.0259277653281746 0.3618816829439725 23.077918551715634 -6.897811022943379 0.9749759003766761 1.029291139714056 0.29518988504114424 0.9854462450513763 0.03704889041271344 0.11303548822853085 0.1866343362793723 0.02861258803796865 0.07366231415637711 1.265286799226614e-07 6.897811022943379 -0.7341012546729118 down ADFSTK(ub)DIYQDLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADFSTKDIYQDLNR 14 1 A0A2R8YFH0;E9PHA6;A0A2R8Y6P0;A0A2R8YG02;P43246;P43246-2;A0A2R8Y7S8 A0A2R8YFH0 MSH2 DNA mismatch repair protein Msh2 1 7780700.0 1830300.0 2499000.0 3451400.0 True False 1772198.1283555652 3496863.7321128375 2547374.8002194203 1.0 1.9731787750828973 1.437409711397871 20.757108472775414 -10.223879546293501 4.8516309359690455 0.9998789623910431 1.70529424324174 0.6979396491826028 0.21872680433751315 154120184.3868646 45.07643906549445 208393.27598769197 0.07487600291596512 5.972009002172205e-11 10.223879546293501 0.7054152808506968 ADFSTK(ub)DIYQDLNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADFSTKDIYQDLNR 14 1 A0A2R8YFH0;E9PHA6;A0A2R8Y6P0;A0A2R8YG02;P43246;P43246-2;A0A2R8Y7S8 A0A2R8YFH0 MSH2 DNA mismatch repair protein Msh2 1 6502300.0 1830300.0 2812400.0 1859600.0 True False 1521975.5460381284 2797249.042982306 2248433.762181072 1.0 1.8379066932210941 1.4773126730150135 20.53751374820969 -10.137922375006719 4.936461771756656 0.9999634959428398 1.6576096831202172 0.8159881616179994 0.1472118923081255 5.914781401434261e-05 1.0329150975938628e-05 0.14254518878045097 0.047512433938349724 7.27909898180424e-11 10.137922375006719 0.6576461871773773 ADGDSK(ub)GSEEVDSHCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADGDSKGSEEVDSHCK 16 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3;Q9Y4W2-4 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 5854700.0 1433700.0 1194100.0 3226900.0 True False 1879594.5839705514 1015944.9345653435 2893011.342610509 1.0 0.54051280165918 1.5391677371718984 20.84199008507322 -6.781571849641895 1.5295036928662076 0.740363089681142 1.5475088889471231 0.7730091730218003 0.19444836086575884 0.24812948989644038 1.1465929284745784 0.10011674183667824 0.23594902874427803 1.6535911921551586e-07 6.781571849641895 0.8071457992659812 ADGDSK(ub)GSEEVDSHCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADGDSKGSEEVDSHCK 16 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3;Q9Y4W2-4 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 8188400.0 1433700.0 1891800.0 4862900.0 True False 1963777.6342856856 1808214.0206539868 3714383.174569255 1.0 0.920783488458313 1.8914479469160181 20.905200146596112 -6.887115175157564 1.0392555539910011 0.944181687602961 1.9703763348561731 0.9789882471677843 0.06379351634561782 0.12151672877325868 0.23574915102214106 0.046937681021026335 0.11586917810030588 1.296835303873988e-07 6.887115175157564 1.0261946472532122 ADGDSK(ub)GSEEVDSHCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADGDSKGSEEVDSHCK 16 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3;Q9Y4W2-4 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 13923900.0 1049300.0 1369600.0 11505000.0 True False 1358339.5347952466 1293380.5560248392 9411208.05126886 1.0 0.952177657274623 6.928465092998628 20.373412714546433 -6.905094307446589 0.928480574702105 0.7850487596333767 7.624977119093868 0.9889352845706127 0.2951649301191776 0.10775258613813679 0.15701908774194112 0.2359409538280195 0.6311695005050203 1.2442443936177683e-07 6.905094307446589 6.839928359460492 up ADGGAEYATYQTK(ub)STTPAEQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADGGAEYATYQTKSTTPAEQR 21 1 P15529-2;P15529-16;P15529-5;P15529-3;P15529-6;P15529-4;P15529-7;R4GN18 P15529-2 CD46 Membrane cofactor protein 1 30903000.0 12015000.0 11361000.0 7527000.0 True False 15751781.353425529 9665983.084831148 6748178.244082348 1.0 0.6136438075131797 0.4284073078893281 23.90901165501019 -13.999999999999424 0.09729161179395737 2.9241774455472296 0.016768886503289573 0.9998072053666317 0.0033062762328518935 12.101602511832057 0.09233152833931112 4.7089424157715305 0.3677412758301357 1.0000000000013253e-14 13.999999999999424 -2.90740855904394 ADGGAEYATYQTK(ub)STTPAEQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADGGAEYATYQTKSTTPAEQR 21 1 P15529-2;P15529-16;P15529-5;P15529-3;P15529-6;P15529-4;P15529-7;R4GN18 P15529-2 CD46 Membrane cofactor protein 1 25202200.0 8517800.0 9016300.0 7668100.0 True False 8247407.101407998 12616555.60938335 5659594.571930966 1.0 1.529760257284917 0.6862271380983194 22.975509191724225 -6.7368942799540825 1.6977831743412155 1.3163215883739778 0.6860296749710004 0.5910910721781791 0.22260465309961872 0.3234397952545328 1.8292932365678738 0.10377133186572371 0.255546754850792 1.8327605158688198e-07 6.7368942799540825 -0.6302919134029774 ADGGAEYATYQTK(ub)STTPAEQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADGGAEYATYQTKSTTPAEQR 21 1 P15529-2;P15529-16;P15529-5;P15529-3;P15529-6;P15529-4;P15529-7;R4GN18 P15529-2 CD46 Membrane cofactor protein 1 35623000.0 14622000.0 10288000.0 10713000.0 True False 22182643.011388354 8452026.019489113 8595570.8543253 1.0 0.38101979169704553 0.38749083460940237 24.40292793378038 -9.878837265485094 6.814088564582848 1.0000000141155725 0.38425531315410366 0.9999171724952303 0.0026417922065275906 5.652443370228511e-10 9.229551397252697e-11 0.002557904362161382 0.0008526347683292985 1.321790829735276e-10 9.878837265485094 -0.6157447009614688 ADGGAEYATYQTK(ub)STTPAEQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADGGAEYATYQTKSTTPAEQR 21 1 P15529-2;P15529-16;P15529-5;P15529-3;P15529-6;P15529-4;P15529-7;R4GN18 P15529-2 CD46 Membrane cofactor protein 1 29896200.0 12015000.0 10672000.0 7209200.0 True False 16457270.193166295 10200475.752415348 5506535.438134581 1.0 0.619815779451138 0.3345959186123778 23.97222171653308 -7.867458208982256 0.2180164576210957 1.2070047074260837 1.313134751068551e-14 0.9998205446953534 0.003651377643335674 0.11809257027808777 0.03390108896627546 0.06052650084453752 0.09273671652809393 1.356881093122974e-08 7.867458208982256 -1.2070047074260706 down ADGGAEYATYQTK(ub)STTPAEQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADGGAEYATYQTKSTTPAEQR 21 1 P15529-2;P15529-16;P15529-5;P15529-3;P15529-6;P15529-4;P15529-7;R4GN18 P15529-2 CD46 Membrane cofactor protein 1 26439600.0 8517800.0 12429000.0 5492800.0 True False 7082928.102520675 12362042.510036651 6641319.0841622865 1.0 1.745329379474746 0.9376516305168722 22.7559144671585 -6.664162921474124 1.9577804431178842 1.4781092235826558 0.9409696014900008 0.2534859539922555 0.317032388660547 0.4747202237123891 3.501954434398628 0.13062214531919789 0.3517040936056761 2.1668910636049032e-07 6.664162921474124 -0.5371396220926551 ADGGAEYATYQTK(ub)STTPAEQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADGGAEYATYQTKSTTPAEQR 21 1 P15529-2;P15529-16;P15529-5;P15529-3;P15529-6;P15529-4;P15529-7;R4GN18 P15529-2 CD46 Membrane cofactor protein 1 30638800.0 14622000.0 10536000.0 5480800.0 True False 18928467.242710475 9949662.338111652 4483350.637757006 1.0 0.525645431853092 0.23685756380953588 24.17405425587283 -8.554771332548976 0.23957922472893176 1.258727735900651 8.608795022288723e-26 0.9994187761112608 0.0075847232097273325 0.1868470876697325 0.06454322216102766 0.1471229990176717 0.11415040356207205 2.7875885208655352e-09 8.554771332548976 -1.258727735900651 down ADGIVSK(ub)NF ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADGIVSKNF 9 1 P63220 P63220 RPS21 40S ribosomal protein S21 1 46277000.0 12518000.0 21326000.0 12433000.0 True False 16411219.224484447 18144243.928096913 11146552.425757382 1.0 1.1055999971669934 0.6792031885801311 23.96817908793684 -6.841172761770549 1.2769916401209735 1.0561696796299047 0.6648545841066177 0.9264441582202995 0.04917477005154639 0.16743298696060785 0.5298725786853251 0.030190033131143785 0.06957322051525923 1.441541794032991e-07 6.841172761770549 -0.391315095523287 ADGIVSK(ub)NF ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADGIVSKNF 9 1 P63220 P63220 RPS21 40S ribosomal protein S21 1 127028000.0 50610000.0 60442000.0 15976000.0 True False 49003413.252513334 84576805.80086596 11791406.330273358 1.0 1.725937035549827 0.24062418406474143 25.546378905500074 -6.773783809496211 1.5598389247800526 1.4143489391297364 0.23101087831271486 0.7449100465655918 0.306284961401644 0.2603300089454592 1.2505164131028794 0.15472340210959143 0.3670623445748043 1.6835118997421647e-07 6.773783809496211 -1.1833380608170214 ADGIVSK(ub)NF ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADGIVSKNF 9 1 P63220 P63220 RPS21 40S ribosomal protein S21 1 77901000.0 42481000.0 12786000.0 22634000.0 True False 64446782.777102366 10504238.402526043 18160379.9791654 1.0 0.16299088875943313 0.2817887751197054 25.941605004375337 -10.790785445864719 7.251456809128274 1.0236402261886262 0.22238983193957046 0.9827964367410694 0.04849903401730143 0.016523621297510047 0.0004767287036511013 0.041861241179323716 0.015652995921346276 1.6188796138451346e-11 10.790785445864719 -0.8012503942490556 ADGIVSK(ub)NF ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADGIVSKNF 9 1 P63220 P63220 RPS21 40S ribosomal protein S21 1 42485500.0 12518000.0 21408000.0 8559500.0 True False 17146242.886230174 20462123.773210995 6537922.388436017 1.0 1.1933881905781087 0.3813034979042843 24.03138914945973 -6.843873498465451 1.264271502595516 1.1028849586253255 0.3524765142559338 0.9309127423407444 0.09103793841676877 0.16432312990978554 0.5085180942420608 0.05642430382476826 0.1301588470822198 1.4326051285116756e-07 6.843873498465451 -0.7504084443693917 down ADGIVSK(ub)NF ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADGIVSKNF 9 1 P63220 P63220 RPS21 40S ribosomal protein S21 1 124885600.0 50610000.0 67526000.0 6749600.0 True False 42084457.40315231 67162224.03513841 8160910.153375659 1.0 1.5958914093094063 0.19391743786066662 25.32678418093435 -6.79120996723286 1.491399211107091 1.332518250435223 0.1784852725477472 0.8052541479005297 0.253524157483803 0.23354969296119335 1.0262009579420355 0.13379086776009141 0.3129763317225116 1.6172979377364098e-07 6.79120996723286 -1.1540329778874758 ADGIVSK(ub)NF ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADGIVSKNF 9 1 P63220 P63220 RPS21 40S ribosomal protein S21 1 79660000.0 42481000.0 23189000.0 13990000.0 True False 54992491.9257 21898511.76523073 11443963.549522072 1.0 0.3982091190706118 0.20810047242419813 25.712731326467786 -13.999999999996362 0.16127982701383312 3.9718934437627404 0.023828454614303538 0.9995330599210143 0.007293827840353398 12.018456308836322 0.12695256038592137 11.172141148832102 0.16822128749178958 1.0000000000083768e-14 13.999999999996362 -3.948064989148437 ADGK(ub)ISEQSDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADGKISEQSDAK 12 1 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 1 8528890.0 1963140.0 2370450.0 4195300.0 True False 2573695.5510748043 2016788.0999417282 3761210.6001592465 1.0 0.7836156452535712 1.4614046321790168 21.295409972947983 -6.820815170485364 1.3683078686415202 0.8834652875210549 1.4764663691097808 0.8862576747900353 0.09533201410362868 0.19242255251678908 0.7076752024181576 0.05474615665381815 0.12615667692060042 1.5107229594358422e-07 6.820815170485364 0.5930010815887259 ADGK(ub)ISEQSDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADGKISEQSDAK 12 1 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 1 9316800.0 2250400.0 3113700.0 3952700.0 True False 2178962.2838066793 4357016.64773099 2917369.29154178 1.0 1.9995833246453527 1.3388801234526615 21.055209794031327 -10.48511269608869 4.897253308332343 0.9979860765169862 1.6692317240490604 0.5776986900732595 0.2697309523911031 0.005945752180546719 0.0006251241997599564 0.2618154149195356 0.08705529054725757 3.272557634979558e-11 10.48511269608869 0.6712456475320742 ADGK(ub)ISEQSDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADGKISEQSDAK 12 1 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 1 8936530.0 1963140.0 2715990.0 4257400.0 True False 2688965.909863709 2595988.5812221244 3251889.8039053134 1.0 0.9654226450768588 1.2093458648831052 21.358620034470874 -6.8709785440709155 1.1288402205435255 0.9803215417412924 1.2239035149453235 0.9656534260742574 0.019971917772768452 0.13592347144756722 0.3231111272324748 0.013721845807059159 0.03254499439088053 1.3459268467212772e-07 6.8709785440709155 0.24358197320403108 ADGK(ub)ISEQSDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADGKISEQSDAK 12 1 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 1 7760200.0 2250400.0 2461900.0 3047900.0 True False 1871307.3096236708 2448637.25605111 3685201.7981026466 1.0 1.3085169087185062 1.9693194052898555 20.835615069465604 -6.95868305438883 0.45361918596611867 0.9794613460165753 2.3247297777654627 0.999718174593365 0.006787930545686057 0.08017505140790894 0.022895804248167888 0.008881294145684716 0.05463126506775576 1.0998081802996534e-07 6.95868305438883 1.3452684317488874 ADGK(ub)ISEQSDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADGKISEQSDAK 12 1 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 1 4139150.0 699190.0 418150.0 3021810.0 True False 905115.2380953863 394879.584916609 2471871.586388942 1.0 0.4362754799571657 2.7310020673063087 19.787741960383705 -6.841732575861964 1.2743023801016375 0.7001465326761942 2.809114244240776 0.9273968280808198 0.26308631200213817 0.16678370349142888 0.5253380291364347 0.16183874766020162 0.3730408659448712 1.4396848155305379e-07 6.841732575861964 2.108967711564582 up ADGTSTYK(ub)QHCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADGTSTYKQHCR 12 1 Q6Q0C0;A0A087WUB0;H3BR17 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 1029090.0 0.0 564620.0 464470.0 True False 0.0 480380.8968715218 416411.09991084464 0.0 ADGTSTYK(ub)QHCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADGTSTYKQHCR 12 1 Q6Q0C0;A0A087WUB0;H3BR17 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 2159150.0 610330.0 871320.0 677500.0 True False 590955.4082277515 1219242.6198737745 500042.42543566576 1.0 2.0631719464760088 0.8461593184082541 19.172689747384812 -6.675833523546708 1.916652870014994 1.6751598327264445 0.8509189200331468 0.3052748906975795 0.4510093518561765 0.4477875138084186 3.1766391601977206 0.18906915666862295 0.5013417395607327 2.1094365972881777e-07 6.675833523546708 -0.8242409126932977 ADGTSTYK(ub)QHCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADGTSTYKQHCR 12 1 Q6Q0C0;A0A087WUB0;H3BR17 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 1105000.0 0.0 560520.0 544480.0 True False 0.0 535754.3730082312 415885.03791759396 0.0 ADGTSTYK(ub)QHCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADGTSTYKQHCR 12 1 Q6Q0C0;A0A087WUB0;H3BR17 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 1698820.0 610330.0 653270.0 435220.0 True False 507516.4372034378 649750.7048460571 526222.4897700831 1.0 1.2802554897066414 1.0368580231011257 18.953095022819088 -10.192256715974345 8.21848588582714 0.9999999635450104 1.1585567564038834 0.3613558405338093 0.09936659964493695 6.639234668839145e-08 6.454406087136696e-09 0.09621131790338458 0.032070432132841734 6.423079301981158e-11 10.192256715974345 0.15855679285887303 ADGYVLEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADGYVLEGK 9 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 18115700.0 4827400.0 1769300.0 11519000.0 False True 4674156.829385163 2475790.716777611 8501828.33740729 1.0 0.5296764330227396 1.818900958555474 22.156274710201536 -6.807981342420788 1.4229862448921113 0.7430604985235614 1.8404329980957363 0.854498307197649 0.20319590905268195 0.20956419115946506 0.8367152030421711 0.11229284837149671 0.26000400278566665 1.5560324783572851e-07 6.807981342420788 1.097372499572175 ADGYVLEGK(ub)ELEFYLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADGYVLEGKELEFYLR 16 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 6766900.0 0.0 4130700.0 2636200.0 True False 0.0 3514415.6613424853 2363431.312216006 0.0 ADGYVLEGK(ub)ELEFYLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADGYVLEGKELEFYLR 16 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 45905800.0 13011400.0 14237000.0 18657400.0 True False 12598360.229080286 19921908.344974197 13770467.229997633 1.0 1.5813096294063145 1.0930364729698567 23.586732632593595 -10.206631217255216 3.9940421834918443 0.9997892132666157 1.3371730511782458 0.38867734949085253 0.19933668187164366 27086277.159469444 23072773.568954732 47310.03218684046 0.06823824746365013 6.213964713429639e-11 10.206631217255216 0.33738383791163007 ADGYVLEGK(ub)ELEFYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADGYVLEGKELEFYLR 16 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 94195100.0 21314000.0 29617000.0 43264100.0 True False 32334896.262120873 24331614.951322805 34712931.67167134 1.0 0.7524877999941625 1.073543931926457 24.946588646103006 -6.700819982629599 1.828111709931114 0.846428445164893 1.0725989708021026 0.4214293959471779 0.10446223416033576 0.393800423823643 2.55925203942113 0.0455788265707128 0.11709096212977747 1.9914986547008269e-07 6.700819982629599 0.22617052563720963 ADGYVLEGK(ub)ELEFYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADGYVLEGKELEFYLR 16 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 8574400.0 0.0 3491100.0 5083300.0 True False 0.0 3336851.6584761203 3882729.2338497387 0.0 ADGYVLEGK(ub)ELEFYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADGYVLEGKELEFYLR 16 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 48654400.0 13011400.0 16327200.0 19315800.0 True False 10819555.602753943 16239242.132904563 23354644.47383157 1.0 1.5009158166136811 2.158558570361894 23.36713790802787 -6.967376686728748 0.31460169913039926 0.9040357692677768 2.77648344366477 0.9999540899813149 0.0032145188623917517 0.07716343650729802 0.012062628714461796 0.010196049515913836 0.058131671705284355 1.0780113000170597e-07 6.967376686728748 1.8724476743969931 ADGYVLEGK(ub)ELEFYLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADGYVLEGKELEFYLR 16 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 143757700.0 21314000.0 41534700.0 80909000.0 True False 27591393.161751542 39223257.433064334 66184392.19644605 1.0 1.4215758226894253 2.398733250200425 24.717714968195455 -6.957061842353663 0.47503964707140994 0.9754149195392966 2.885294234801489 0.9996452109681242 0.011035041331215455 0.0807679482145191 0.025140226917027716 0.013642058927233924 0.08062479295249023 1.1039214133010226e-07 6.957061842353663 1.9098793152621925 up ADHGEPIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADHGEPIGR 9 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 8633380.0 364280.0 4977900.0 3291200.0 False True 477574.6076925385 4235216.723702223 2950658.195419664 1.0 8.868178197675128 6.178423534023591 18.865366605993636 -9.4411194172012 9.69635675650758 1.0000011159260316 7.523300865849367 0.8869083531783074 1.0980877432031602 0.0 0.0 1.0632188696818052 0.35440629517499433 3.621434067799686e-10 9.4411194172012 6.523299749923336 ADHGEPIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADHGEPIGR 9 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 4301580.0 1651600.0 720680.0 1929300.0 False True 1599170.8620401327 1008451.282296551 1423958.4522406366 1.0 0.6306088400147719 0.8904354663041009 20.608892659892806 -10.178307452043207 5.457187119160224 1.0000078548040632 0.7605221531594004 0.5311034677740423 0.10607377599973825 1.0137397118023256e-05 1.5265525275505498e-06 0.10270885952476963 0.0342351639930085 6.632733500741067e-11 10.178307452043207 -0.23948570164466276 ADHGEPIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADHGEPIGR 9 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 5890980.0 364280.0 3527800.0 1998900.0 False True 498964.16029684705 3371930.1311254515 1526800.988637744 1.0 6.757860382435886 3.059941194432501 18.928576667516527 -9.334989074905247 10.030801363532515 0.9999265410349697 4.908900788434355 0.5983642079320055 1.5096691873717027 0.0 0.0 1.4617309049740592 0.487243634991353 4.623926531841904e-10 9.334989074905247 3.9089742473993856 ADIDLTK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADIDLTKR 8 1 P62269 P62269 RPS18 40S ribosomal protein S18 1 8990100.0 3179500.0 2630000.0 3180600.0 True False 4168355.2903218013 2237614.251659707 2851502.0224695522 1.0 0.5368098676365375 0.6840832471959014 21.99104682048666 -10.917303156096414 11.339079408597028 1.04496358873278 0.6104465574162194 0.9031830376297 0.06012410543594595 0.03207205135400359 0.0002339037139964593 0.027319424941628204 0.019404971588253116 1.2097533792220905e-11 10.917303156096414 -0.4345170313165605 ADIDLTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADIDLTKR 8 1 P62269 P62269 RPS18 40S ribosomal protein S18 1 12973800.0 4043500.0 3552600.0 5377700.0 True False 3915141.305799993 4971171.706564254 3969119.042458131 1.0 1.2697298304916427 1.013786919153639 21.900632947721196 -10.700323538741769 2.8015807439525933 0.9794987417309323 1.1417583749352576 0.2902894163147187 0.1044882579219316 13460234.928139184 12363347.641949687 1947616.24658876 0.041163123206380256 1.9937764469967986e-11 10.700323538741769 0.16225963320432524 ADIDLTK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADIDLTKR 8 1 P62269 P62269 RPS18 40S ribosomal protein S18 1 10048700.0 3179500.0 2639800.0 4229400.0 True False 4355047.072756738 2523164.9073487655 3230502.827227209 1.0 0.5793657026424759 0.7417836761021059 22.05425688200955 -10.06885256126407 5.043371605959669 1.0000068331612697 0.660574689370822 0.8534404231055186 0.06630686001060038 5.09462621458279e-06 9.407079938934612e-07 0.06420263320576355 0.02140044704596596 8.5338978234319e-11 10.06885256126407 -0.3394321437904477 ADIDLTK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADIDLTKR 8 1 P62269 P62269 RPS18 40S ribosomal protein S18 1 13275200.0 4043500.0 5972900.0 3258800.0 True False 3362349.4074223745 5940722.802172173 3940200.013011229 1.0 1.7668368400553638 1.1718591780834113 21.681038223155472 -10.128190068289918 4.517383215652234 0.9999553877040247 1.469348008976318 0.4534659021744396 0.24289861347260816 169550339.60447633 10.32389912262677 95408.6625085813 0.08315065609923142 7.444061144521139e-11 10.128190068289918 0.4693926212722933 ADIDLTK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADIDLTKR 8 1 P62269 P62269 RPS18 40S ribosomal protein S18 1 16516800.0 4490500.0 2553700.0 9472600.0 True False 5813040.77098834 2411584.3501172843 7748683.997083825 1.0 0.4148576356376156 1.3329829090062248 22.47086159657562 -6.73453788941246 1.7067793503038324 0.6496566343452571 1.3328971547979502 0.5801498985465192 0.245904103040697 0.32778576380476343 1.8726558831169309 0.11408320896850027 0.2816367827295388 1.8427317154155336e-07 6.73453788941246 0.6832405204526931 ADIFMFDEPSSYLDVK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADIFMFDEPSSYLDVKQR 18 1 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 11662800.0 3310700.0 4550600.0 3801500.0 True False 4340359.760864403 3871668.2180998707 3408157.2465629093 1.0 0.8920155082556589 0.785224597576713 22.04938319810086 -6.971262433257626 0.22601414020871935 1.0456558574727575 0.6285474120078468 0.9999906197971828 0.0002684830513834842 0.07589519497394041 0.007547953650327121 0.002826386962171537 0.010690297419534214 1.0684090713274331e-07 6.971262433257626 -0.41710844546491066 ADIFMFDEPSSYLDVK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 2 ADIFMFDEPSSYLDVKQR 18 1 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 54589000.0 14230000.0 9671500.0 30687500.0 True False 13778276.439108184 13533380.386206206 22649523.144733608 1.0 0.9822259297827074 1.6438575060408374 23.715892093017835 -6.900730521099951 0.9566726816569902 0.9730396952306736 1.7143377155939155 0.9869249972173065 0.03519480811033576 0.1108690945644013 0.1744186125666859 0.027554246752170785 0.07195502624575538 1.2568095697455632e-07 6.900730521099951 0.7412980203632419 ADIFMFDEPSSYLDVK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 2 ADIFMFDEPSSYLDVKQR 18 1 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 145481800.0 26794200.0 38177600.0 80510000.0 True False 40648760.31840664 31364508.997049734 64597163.2112134 1.0 0.7715981680958472 1.5891545696650042 25.276708018731796 -6.832165565651818 1.3183939606832842 0.8781308138133169 1.6121123846012566 0.9100932559042312 0.10327452138640549 0.17816320581288714 0.6049069814301162 0.06149276433318561 0.14149610849135502 1.4717513211831782e-07 6.832165565651818 0.7339815707879397 ADIFMFDEPSSYLDVK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ADIFMFDEPSSYLDVKQR 18 1 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 53573900.0 14230000.0 13851600.0 25492300.0 True False 11832875.495887332 13776978.681472678 30822622.06692222 1.0 1.164296766771614 2.6048294074956693 23.49629736845211 -6.928431709312943 0.7595537034151841 0.9767724847083922 2.8890904159725763 0.9962210070594375 0.04431783754002016 0.09346015348646805 0.08172928134293535 0.04000542167662566 0.13148508425929106 1.1791479239211726e-07 6.928431709312943 1.9123179312641843 up ADIFMFDEPSSYLDVK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ADIFMFDEPSSYLDVKQR 18 1 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 118396000.0 26794200.0 31991800.0 59610000.0 True False 34685620.09264349 30211428.206947666 48761591.650250964 1.0 0.8710072971523792 1.4058157680333025 25.047834340824245 -6.843004403958924 1.2683807375793976 0.9313842067916777 1.4244776764281912 0.9295002162233853 0.060505066255026545 0.16531439122820996 0.5153203652878731 0.03738559218904625 0.08621067551886061 1.435474876860976e-07 6.843004403958924 0.49309346963651357 ADIK(ub)QYIGPPSAAAIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADIKQYIGPPSAAAIFK 17 1 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 14656000.0 3181300.0 4662300.0 6812400.0 True False 4170715.107753028 3966703.013503062 6107518.197155108 1.0 0.9510846248235167 1.4643815363465407 21.991863337636364 -6.883532577255449 1.0598581338537612 0.9679946042455404 1.503322095062191 0.9764267241334942 0.03551357237375624 0.12454883185850872 0.25374436587645693 0.02572343520374945 0.06280588567369488 1.3075774513687546e-07 6.883532577255449 0.5353274908166507 ADIK(ub)QYIGPPSAAAIFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADIKQYIGPPSAAAIFK 17 1 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 15974700.0 3448600.0 4222300.0 8303800.0 True False 3339126.0806682054 5908286.409003619 6128785.671339752 1.0 1.7694109974491556 1.8354460188916548 21.67103913787365 -11.180125006999159 0.4278157358105654 3.32930270385243e-19 1.8377950430140102 0.9996587556442423 0.007005398276670292 3.1885955229084204 0.21043197934653016 3.072345792608903 0.015684452679118693 6.605033018662772e-12 11.180125006999159 1.8377950430140102 ADIK(ub)QYIGPPSAAAIFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADIKQYIGPPSAAAIFK 17 1 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 13399100.0 3448600.0 4345600.0 5604900.0 True False 2867663.698883845 4322189.390265934 6776858.675870445 1.0 1.5072162722386941 2.363198543297856 21.451444413307925 -6.96322532269373 0.3873091638707597 0.9458266384833751 2.9552121063132586 0.9998717522755927 0.006370816058975562 0.07856851298241657 0.017016542056336157 0.011070266540785117 0.07208737620522691 1.0883652760641424e-07 6.96322532269373 2.0093854678298833 ADILEDK(ub)DGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADILEDKDGK 10 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 17800400.0 6146300.0 5720200.0 5933900.0 True False 8057858.820853874 4866768.457164965 5319916.949988072 1.0 0.6039778761784317 0.6602147131468769 22.941965098037507 -10.315267983255117 5.674167145123586 1.000047912656324 0.6320962946627516 0.9827777435597826 0.02295859255347368 1.3917335110270778e-05 1.6794450804555976e-06 0.022232447834472775 0.007409853884328834 4.838736991245193e-11 10.315267983255117 -0.36795161799357234 ADILEDK(ub)DGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADILEDKDGK 10 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 24119000.0 5049100.0 8097900.0 10972000.0 True False 4888819.084237614 11331433.699990636 8098104.047055548 1.0 2.317826351260391 1.6564540244831756 22.22105458724896 -10.285021566514898 6.79694539290796 0.9999863632945013 1.9871401878717834 0.7481316209689941 0.27000412176690575 5.579565828748319e-05 5.869137700687982e-06 0.26143396600160673 0.08714345558421546 5.187742766146083e-11 10.285021566514898 0.9871538245772821 ADILEDK(ub)DGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADILEDKDGK 10 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 94750000.0 13619000.0 18906000.0 62225000.0 True False 20661018.682266347 15532076.5867478 49926201.47581364 1.0 0.751757540400426 2.416444331404919 24.300408051600527 -6.86895432586097 1.1396894283224213 0.8604679846051102 2.5119868277339883 0.9636243936821483 0.1398514923516895 0.137857373134263 0.3353292664400498 0.09529619962680172 0.22520465455979793 1.3522147662390948e-07 6.86895432586097 1.651518843128878 up ADILEDK(ub)DGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADILEDKDGK 10 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 19333700.0 6146300.0 6524300.0 6663100.0 True False 8418753.207512107 6236034.853025047 5089413.010852048 1.0 0.7407314004003103 0.6045328667326574 23.005175159560398 -13.999999999681341 0.08094137725752534 2.3902016256439897 0.20480387036552541 0.9998827612270291 0.0017760996270484903 12.249159705198268 0.08032149708049668 3.0359933013449245 0.3625991156255756 1.0000000007337392e-14 13.999999999681341 -2.1853977552784642 ADILEDK(ub)DGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADILEDKDGK 10 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 19023500.0 5049100.0 9930900.0 4043500.0 True False 4198550.363055855 9877400.2705707 4888977.154968355 1.0 2.3525739639768366 1.1644440895571353 22.001459862683237 -6.614860013429181 2.135407576166533 1.900667983738296 1.168818524635349 0.06587615339386343 0.5824142838843923 0.5993503133422382 5.185764437859212 0.22465729038422066 0.6462684967604276 2.427392392792215e-07 6.614860013429181 -0.731849459102947 ADILEDK(ub)DGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADILEDKDGK 10 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 187426800.0 13619000.0 15926000.0 157881800.0 True False 17630063.970624704 15039704.09992085 129148932.4040695 1.0 0.8530714423373662 7.325494259082557 24.071534373692977 -6.901706698678091 0.9504149225799224 0.7433566129623972 8.028932596552464 0.9873964588794565 0.3387155829348581 0.11015990914989239 0.17041918771881828 0.2664097334885622 0.6992808659989875 1.253987771245081e-07 6.901706698678091 7.285575983590066 up ADILEDK(ub)DGK(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADILEDKDGKSR 12 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 2 6876200.0 2393600.0 2440400.0 2042200.0 True False 3138032.7796553755 2076301.8326046946 1830892.734165667 1.0 0.6616571522343109 0.5834523928608353 21.581428991993235 -13.999999999999996 0.2057870987561006 2.9236701576779214 0.5354636784431839 0.9994880826798228 0.00409004913086517 12.651336328113478 0.1438114297345554 9.820633044687563 0.04773067478375717 1.0000000000000082e-14 13.999999999999996 -2.3882064792347375 ADILEDK(ub)DGK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADILEDKDGKSR 12 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 2 7251400.0 1949500.0 2683800.0 2618100.0 True False 1887614.18960235 3755455.3358321115 1932341.0686835703 1.0 1.989524849155349 1.0236949262871575 20.84813249100163 -6.6405265045861945 2.042322064525118 1.6468315714868185 1.0276999797060884 0.15667921699795728 0.4233322498388679 0.5320728424816735 4.242164261554384 0.16875009381983866 0.4688354423999983 2.2880920671942217e-07 6.6405265045861945 -0.6191315917807301 ADILEDK(ub)DGK(ub)SR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADILEDKDGKSR 12 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 2 31092000.0 4654200.0 8086800.0 18351000.0 True False 7060761.66759703 6643647.357543214 14723916.806470964 1.0 0.9409250262662142 2.0853156500156893 22.75139238947706 -6.894733282698416 0.9939806763164605 0.9453042650833067 2.1933714114494722 0.9837583349632121 0.06704763772024856 0.11538596501478908 0.2000953931071227 0.05105046180603581 0.1296386273747827 1.274285429496193e-07 6.894733282698416 1.2480671463661657 up ADILEDK(ub)DGK(ub)SR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADILEDKDGKSR 12 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 2 7477500.0 2393600.0 2315700.0 2768200.0 True False 3278578.60460781 2213384.7170041394 2114408.172868577 1.0 0.6751049719818778 0.6449161139211139 21.644639053516126 -13.999999999999998 0.3361554004521864 4.6708504908686 0.6399474153362296 0.999727470566008 0.0026536590922761768 19.35652408077124 0.18574794966537997 50.394274818594006 0.009457225401064142 1.0000000000000041e-14 13.999999999999998 -4.03090307553237 ADILEDK(ub)DGK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADILEDKDGKSR 12 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 2 8722400.0 1949500.0 3927800.0 2845100.0 True False 1621095.6274934912 3906640.1617927435 3439997.2557439026 1.0 2.4098764413010723 2.1220199458947184 20.628537766435905 -10.260768345824133 4.995309179535817 0.9997431229734974 2.2659481935986543 0.9626699244551177 0.11751692215119416 0.00033625917602436305 4.9761116748055464e-05 0.11380734493715194 0.03792842353205091 5.48569495758183e-11 10.260768345824133 1.2662050706251569 ADILEDK(ub)DGK(ub)SR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADILEDKDGKSR 12 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 2 41783500.0 4654200.0 8076300.0 29053000.0 True False 6024953.647997755 7626846.805361724 23765652.108953856 1.0 1.265876428426353 3.9445369205208385 22.52251871156951 -6.9260746951952825 0.7783402060872996 0.952797307965766 4.443237551084832 0.9957088978996331 0.08711300565675359 0.09472777019922216 0.08804576105263603 0.07758360042555204 0.24780909721332278 1.1855648229146919e-07 6.9260746951952825 3.4904402431190658 up ADILEDKDGK(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADILEDKDGKSR 12 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 45139620.0 15205000.0 14849620.0 15085000.0 True False 19933902.245429475 12634114.579365406 13524148.90553768 1.0 0.6338003680268979 0.6784496451836745 24.24872082291112 -10.708527752243409 10.362989851438861 1.0003280021190568 0.6561250067254247 0.9875137469685792 0.01822799106970125 0.0001382579683612702 3.8886523299980775e-06 0.017664929122985087 0.005883058820647537 1.956465742058226e-11 10.708527752243409 -0.3442029953936321 ADILEDKDGK(ub)SR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADILEDKDGKSR 12 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 256287390.0 33981390.0 49393800.0 172912200.0 True False 51552253.002377376 40579090.47447914 138736027.8798903 1.0 0.7871448503445194 2.6911729323157294 25.61953214368328 -6.8791452058699365 1.0846095056282756 0.8695257923549041 2.8238889921398576 0.9729869999983154 0.1400054342250578 0.12838745832978027 0.276914342459224 0.09951505296285748 0.2401282823278412 1.3208539343273656e-07 6.8791452058699365 1.9543631997849533 up ADILEDKDGK(ub)SR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADILEDKDGKSR 12 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 31731220.0 15205000.0 16018000.0 508220.0 True False 20826699.399674866 15310271.795557436 388188.9031194525 1.0 0.7351271318486716 0.018639002545238283 24.311930884434013 -7.346111067864433 0.7511957447944841 0.9914207555895108 2.5525723812613885e-17 0.9900459727670062 0.041358489477091906 0.10703736437880647 0.1225065915373889 0.03598013978624631 0.0696389164236426 4.507014259722747e-08 7.346111067864433 -0.9914207555895108 down ADILEDKDGK(ub)SR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADILEDKDGKSR 12 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 362781290.0 33981390.0 48939900.0 279860000.0 True False 43989579.22833875 46216351.54337035 228928351.60609353 1.0 1.0506204504360679 5.204149610474438 25.39065846577573 -6.9095598680218595 0.8987247356364798 0.8696015225926488 5.735904542625873 0.9907544651913823 0.18942589049767186 0.10470984033232497 0.14035048626671218 0.1547488043538113 0.4258864269701254 1.2315162080294164e-07 6.9095598680218595 4.866303020033224 up ADKDYHFK(ub)VDNDENEHQLSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADKDYHFKVDNDENEHQLSLR 21 2 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 25916000.0 11185000.0 8389600.0 6341400.0 True False 14663643.315694083 7137904.382404658 5685252.759004081 1.0 0.4867756415464062 0.3877107916911287 23.80574026293944 -13.999999999999988 0.23128500653681408 4.259219419671912 0.3401297625421053 0.9995115753662681 0.005930646926230055 13.331652212117406 0.15226516367956924 19.968067570194716 0.05101564677480151 1.0000000000000286e-14 13.999999999999988 -3.919089657129807 ADKDYHFK(ub)VDNDENEHQLSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADKDYHFKVDNDENEHQLSLR 21 2 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 30972300.0 9718100.0 8240200.0 13014000.0 True False 9409604.234918986 11530554.83207531 9605242.988368656 1.0 1.2254027421563056 1.0207913902184809 23.165702614241116 -10.352227365964827 3.4347774136843934 0.9992812248935935 1.1230970660452566 0.3255028430068305 0.08353223547621029 45878350.89053925 74959808.3812054 345803.81600482075 0.0330190037641813 4.4439855081462605e-11 10.352227365964827 0.12381584115166311 ADKDYHFK(ub)VDNDENEHQLSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADKDYHFKVDNDENEHQLSLR 21 2 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 118265000.0 26084000.0 36958000.0 55223000.0 True False 39571334.99583189 30362556.145828 44308149.84489925 1.0 0.767286626772287 1.1197031853882689 25.237952401732862 -6.7286211108635765 1.7281172585265334 0.859738458376778 1.119445886785 0.552881863860771 0.0978386006426719 0.3388503761809156 1.9818161447839147 0.04487598467313231 0.11153695984977646 1.868008676641349e-07 6.7286211108635765 0.2597074284082219 ADKDYHFK(ub)VDNDENEHQLSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADKDYHFKVDNDENEHQLSLR 21 2 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 32294400.0 11185000.0 9327400.0 11782000.0 True False 15320396.763259664 8915284.626412924 8999334.257906785 1.0 0.5819225679450388 0.5874086942375003 23.868950324462332 -9.927300139022893 5.905693783738886 1.00000019202641 0.5846656310913085 0.9998691592022269 0.0022397016808697796 5.663884986875748e-09 1.0232152660591907e-09 0.002168582829042809 0.0007228606091039268 1.1822242433171856e-10 9.927300139022893 -0.41533456093510157 ADKDYHFK(ub)VDNDENEHQLSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADKDYHFKVDNDENEHQLSLR 21 2 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 27850000.0 9718100.0 11196000.0 6935900.0 True False 8081030.734826605 11135684.925768003 8386164.622021779 1.0 1.3780030408468606 1.0377592781425948 22.946107889675392 -10.61627821359712 6.8914846694902305 0.9995285861669905 1.2078811594947279 0.33232027589040014 0.1389039344650088 0.0010083029851996768 5.6142783587425156e-05 0.1347906197995287 0.044831052075472125 2.4194786068201267e-11 10.61627821359712 0.20835257332773738 ADKDYHFK(ub)VDNDENEHQLSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADKDYHFKVDNDENEHQLSLR 21 2 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 158928000.0 26084000.0 45203000.0 87641000.0 True False 33766252.192508556 42687413.31336955 71691237.27259926 1.0 1.2642034736339576 2.1231624067685195 25.00907872382531 -6.949630860104618 0.5628827537850756 0.9889308857809921 2.439689587463006 0.9991719874146303 0.013797129048407047 0.08363433784183671 0.03657860021180439 0.014738764891820846 0.071448330201604 1.1229725485036504e-07 6.949630860104618 1.4507587016820138 up ADLATDQK(ub)EALLELLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADLATDQKEALLELLR 16 1 Q13895 Q13895 BYSL Bystin 1 7813000.0 2536000.0 2474500.0 2802500.0 True False 2455496.0681362147 3462580.7543470324 2068441.176802145 1.0 1.4101349211180865 0.842372017468611 21.227583081743397 -6.712899838185819 1.7847329381081052 1.2513930718219342 0.8435825289130398 0.4788787800160057 0.17275290754776176 0.3693012239991518 2.294756829513508 0.07697477240301122 0.1948774242409109 1.936868614578428e-07 6.712899838185819 -0.4078105429088944 ADLATDQK(ub)EALLELLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADLATDQKEALLELLR 16 1 Q13895 Q13895 BYSL Bystin 1 8789000.0 2536000.0 3905700.0 2347300.0 True False 2108796.3638489284 3884659.2188792475 2838109.577311049 1.0 1.8421215464299519 1.3458433568858184 21.007988357177673 -10.4588532873719 5.325843898928104 0.9992206892514895 1.593982451657889 0.6563585411307206 0.20260472247591296 0.0018770673084085084 0.00019072408340232587 0.196410451825173 0.06539039300101274 3.476535853549304e-11 10.4588532873719 0.5947617624063996 ADLIAYLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADLIAYLK 8 0 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 0 17418800.0 4016800.0 3213000.0 10189000.0 False True 5266063.698746536 2733632.9241759083 9134740.019789428 1.0 0.5191036570306937 1.734642902622644 22.328293541773462 -6.799372814347083 1.4585068226046807 0.7344558070168428 1.7511568357702307 0.8303104307363862 0.20589817108721006 0.2216562710999579 0.9309596746149305 0.11106247504178461 0.25838566748631975 1.5871836668203623e-07 6.799372814347083 1.016701028753388 ADLIAYLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADLIAYLK 8 0 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 0 12570200.0 4016800.0 3851800.0 4701600.0 False True 5501919.509938438 3681614.739800734 3591178.91249148 1.0 0.6691509632502654 0.6527138221496196 22.391503603296353 ADLIAYLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADLIAYLK 8 0 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 0 7333400.0 2897900.0 1217000.0 3218500.0 False True 2409732.248737307 1210443.7794444126 3891473.469337376 1.0 0.5023146368558922 1.6148986973040251 21.20044142329869 -6.785073649676436 1.5157501037927625 0.7200555612983306 1.6252132036476166 0.7850491754885475 0.21097386751649885 0.24276574844279286 1.1018437895166253 0.10958620942277991 0.25754157826550567 1.6403115779513607e-07 6.785073649676436 0.905157642349286 ADLINNLGTIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADLINNLGTIAK 12 0 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 0 349633000.0 25393000.0 158640000.0 165600000.0 False True 33290468.906161804 134971530.37387672 148465300.54736754 1.0 4.054359545199874 4.45969388313085 24.988605855621824 -9.914918201169312 0.4935732335287925 1.2529065805832458e-22 4.452695390748949 0.9990908272055617 0.046563547148225505 1.2020548616630862 0.22340185827220066 1.9541915704201054 0.08299003094242789 1.2164150893550606e-10 9.914918201169312 4.452695390748949 ADLINNLGTIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADLINNLGTIAK 12 0 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 0 374524000.0 95141000.0 58613000.0 220770000.0 False True 92120801.0325504 82017476.56275703 162943714.04196593 1.0 0.890325264689965 1.7688047890985081 26.45702362029088 -6.875608547370457 1.1039511611266575 0.9352718341041998 1.8260592779520985 0.9699694119194233 0.06773028328393146 0.13159341215029902 0.29637152356065727 0.0474317707116197 0.11353087388487919 1.3316541676627501e-07 6.875608547370457 0.8907874438478988 ADLINNLGTIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADLINNLGTIAK 12 0 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 0 1041273300.0 8509700.0 1025900000.0 6863600.0 False True 12909837.042402657 842820129.606714 5507006.451577256 1.0 65.28510986145308 0.42657443571823306 23.62196745419813 -3.033071973726952 3.73507586329194e-22 9.854832063155712 49.485683781252085 0.0 31.334721911632847 0.0 0.2960203089599095 1565247340.309196 1565247361.933939 0.0009266762366492364 3.033071973726952 39.63085171809637 ADLINNLGTIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADLINNLGTIAK 12 0 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 0 354213000.0 25393000.0 161040000.0 167780000.0 False True 34781478.32002258 153924720.31193462 128153819.53756604 1.0 4.425479529526641 3.684542053055634 25.051815917144715 -10.528671694781822 8.827978152327079 0.9997890707967432 4.055010791291138 0.9577477323343131 0.30248645810989744 0.0012558219200300034 6.704829262887611e-05 0.29289607936977213 0.09762708455940837 2.960249423558253e-11 10.528671694781822 3.0552217204943943 ADLINNLGTIAK(ub)SGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADLINNLGTIAKSGTK 16 1 P08238;P07900;P07900-2;Q14568 P08238;P07900 HSP90AB1;HSP90AA1;HSP90AA2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 439470000.0 135200000.0 130590000.0 173680000.0 True False 177248509.27866262 111106481.03583314 155709259.65620065 1.0 0.6268401437506942 0.8784799392101015 27.40119825304987 -9.941207399249464 5.253855169261758 1.0000006769417582 0.7526600414785704 0.5629669709204493 0.10273151631536766 8.145239965344672e-07 1.6419378179371666e-07 0.09946963419015872 0.03315645431741708 1.1449660272780835e-10 9.941207399249464 -0.24734063546318785 ADLINNLGTIAK(ub)SGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADLINNLGTIAKSGTK 16 1 P08238;P07900;P07900-2;Q14568 P08238;P07900 HSP90AB1;HSP90AA1;HSP90AA2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 511320000.0 163310000.0 139680000.0 208330000.0 True False 158125813.44137445 195454952.42157727 153762123.23396677 1.0 1.2360723917732932 0.9724036821538595 27.236497660533157 -6.670702240707501 1.9351849745139824 1.1505964474756656 0.9734734707094335 0.2820283265625555 0.10026282489030056 0.4595089535815269 3.318368057487465 0.041703300289764364 0.11130659709507065 2.1345078645527776e-07 6.670702240707501 -0.17712297676623212 ADLINNLGTIAK(ub)SGTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADLINNLGTIAKSGTK 16 1 P08238;P07900;P07900-2;Q14568 P08238;P07900 HSP90AB1;HSP90AA1;HSP90AA2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 868030000.0 261200000.0 171830000.0 435000000.0 True False 396259496.2778444 141165593.9860821 349022059.3327273 1.0 0.3562453273980375 0.880791659534146 28.56187026865704 -10.16923073026802 7.576959009463582 1.0000001935391307 0.6185184934661447 0.41356171087733984 0.21414514336365598 7.000173356530867e-07 7.666150334438598e-08 0.20734524852653977 0.0691150478265533 6.77281588506489e-11 10.16923073026802 -0.381481700072986 ADLINNLGTIAK(ub)SGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADLINNLGTIAKSGTK 16 1 P08238;P07900;P07900-2;Q14568 P08238;P07900 HSP90AB1;HSP90AA1;HSP90AA2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 374320000.0 135200000.0 123120000.0 116000000.0 True False 185187093.6426203 117680151.29660574 88603189.09499139 1.0 0.6354662680959208 0.4784522903414669 27.46440831457276 -13.999999999999995 0.11485260648891397 2.746246873459774 0.2095414644384045 0.9997185260968743 0.0036652555459189807 11.986347044976677 0.10359878986475358 4.813374058344121 0.2386472282778554 1.0000000000000123e-14 13.999999999999995 -2.5367054090213697 ADLINNLGTIAK(ub)SGTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADLINNLGTIAKSGTK 16 1 P08238;P07900;P07900-2;Q14568 P08238;P07900 HSP90AB1;HSP90AA1;HSP90AA2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 476611000.0 163310000.0 227790000.0 85511000.0 True False 135799500.85968804 226562850.05722505 103390954.74180783 1.0 1.6683629072489472 0.7613500350684966 27.016902935967433 -6.709242263131616 1.7976944176185994 1.4112037018128079 0.7635072605353093 0.46161590621480153 0.28167706842283974 0.37659173274817254 2.371881196135235 0.12470751604013243 0.3171322604283985 1.9532495677284587e-07 6.709242263131616 -0.6476964412774986 ADLLLSTQPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADLLLSTQPGR 11 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5GZI0 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 8097600.0 1422400.0 3991900.0 2683300.0 False True 1864780.1745411963 3396324.0803043237 2405657.856031107 1.0 1.8212999723358507 1.2900490303759187 20.83057414093537 -10.257868223042006 4.292029304955958 0.9996378016665142 1.5556745013695146 0.5932889272098383 0.2168822889089249 0.0007532424296239726 0.0001302423648325103 0.21012967267307586 0.06999845774617022 5.522449802627856e-11 10.257868223042006 0.5560366997030004 ADLLLSTQPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADLLLSTQPGR 11 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5GZI0 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 4634800.0 1422400.0 1326800.0 1885600.0 False True 1948299.7189146683 1268177.5888591327 1440260.115150998 1.0 0.6509150396868052 0.7392395026127285 20.89378420245826 -9.853947190967796 6.226220489901337 1.000000022315792 0.6950772711496682 0.9407975259277781 0.036058310996003526 1.1166352620282176e-08 2.0053858226639263e-09 0.034913312096055915 0.011637769831605062 1.39975751894612e-10 9.853947190967796 -0.3049227511661239 ADLTALFLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADLTALFLPR 10 0 Q13045;Q13045-2;Q13045-3 Q13045 FLII Protein flightless-1 homolog 0 4822390.0 954690.0 1467600.0 2400100.0 False True 1251607.8352311105 1248639.8006599948 2151760.675384883 1.0 0.9976286225704495 1.7191971916567288 20.255351164506287 -6.906159819992409 0.9214985318174826 0.9748555667855913 1.805173385022289 0.9893895651109594 0.034980456902742735 0.10701259080973208 0.1529514106694858 0.028105875361199212 0.07566720735295837 1.2411954646849207e-07 6.906159819992409 0.8303178182366978 ADLTALFLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADLTALFLPR 10 0 Q13045;Q13045-2;Q13045-3 Q13045 FLII Protein flightless-1 homolog 0 3101890.0 1228700.0 527390.0 1345800.0 False True 1189695.5910563758 737979.5773025166 993294.6068654174 1.0 0.62030958410734 0.8349149264169614 20.18216104583724 -10.157708699841303 5.309800591800332 1.0000091788594505 0.7276122552620399 0.6823372575338501 0.0876122641227033 9.520254796104842e-06 1.5102562952609384e-06 0.08483306763890054 0.028276736655840237 6.954906569442857e-11 10.157708699841303 -0.27239692359741063 ADLTALFLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADLTALFLPR 10 0 Q13045;Q13045-2;Q13045-3 Q13045 FLII Protein flightless-1 homolog 0 4348490.0 954690.0 1632300.0 1761500.0 False True 1307664.6925271663 1560179.5887057295 1345469.979231271 1.0 1.1931037043529544 1.028910535644304 20.31856122602918 -10.663455737523867 3.1463415297654396 0.9903075593654891 1.1110071199339517 0.37866547760576563 0.06703158063774477 24631407.026174072 12991.735854679207 1729622.6163943599 0.02294669189834693 2.1704223976617532e-11 10.663455737523867 0.12069956056846265 ADMGGAATICSAIVSAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADMGGAATICSAIVSAAK 18 0 P28838-2;P28838;H0Y9Q1 P28838-2 LAP3 Cytosol aminopeptidase 0 6592580.0 994780.0 2998200.0 2599600.0 False True 1304166.2134632238 2550880.2468920643 2330618.3291240134 1.0 1.9559471948887417 1.7870562088363244 20.314696319305547 -10.179134891040594 4.483440943808329 0.9998196678821644 1.8715017018471352 0.9726048206138272 0.06894945639746337 48370825.66537869 31.24610257556882 90861.14237495224 0.023603232862865867 6.620108524535172e-11 10.179134891040594 0.8716820339649708 ADMGGAATICSAIVSAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADMGGAATICSAIVSAAK 18 0 P28838-2;P28838;H0Y9Q1 P28838-2 LAP3 Cytosol aminopeptidase 0 6482880.0 994780.0 3258700.0 2229400.0 False True 1362577.0489186812 3114719.8589201523 1702861.635934255 1.0 2.285903656891875 1.2497360331187275 20.37790638082844 -6.592479860416615 2.2194900452334387 1.8689870889376248 1.2528503191045246 0.0 0.5568783897208212 0.6623769399461912 6.155224071338957 0.20916379503457183 0.6203190312138621 2.5557604168609833e-07 6.592479860416615 -0.6161367698331002 ADPSQFELLK(ub)VLGQGSFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADPSQFELLKVLGQGSFGK 19 1 B4DG22;B1AXG1;B7ZB17;P51812;B1AXG2;A0A2R8YGB7 B4DG22 RPS6KA3 Ribosomal protein S6 kinase alpha-3 1 2806450.0 811660.0 930390.0 1064400.0 True False 674931.2526347091 925377.8044020433 1286961.1187704522 1.0 1.3710697212340863 1.9068032688463903 19.36438103358689 -6.96588454763627 0.3425312966827135 0.9435697439599462 2.3521757056549264 0.9999302354815635 0.0031090500414047762 0.07766205892793618 0.013808605498570499 0.007505548617950429 0.0462852090868368 1.0817214767169984e-07 6.96588454763627 1.4086059616949802 ADQCYEDVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADQCYEDVR 9 0 H3BNA2;H3BU76;H3BSL1;P31146;H3BRY3;H3BTU6;H3BRJ0 H3BNA2;P31146 CORO1A Coronin;Coronin-1A 0 6468330.0 2839100.0 735330.0 2893900.0 False True 2748974.324544771 1028951.1036952934 2135900.7748609195 1.0 0.3743036428198315 0.7769809837036669 21.390462001447897 -10.057908912185864 5.431685341153259 1.0000032403335792 0.5756423132615266 0.5968998436886535 0.16439233602551015 6.450703820947046e-06 1.118763992236724e-06 0.15917341141315336 0.05305739830574466 8.751673113336278e-11 10.057908912185864 -0.42436092707205264 ADQFEYVMYGK(ub)VYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADQFEYVMYGKVYR 14 1 C9JLU1;P52434;P52434-3;P52434-4 C9JLU1 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 1 9723200.0 1393000.0 2814100.0 5516100.0 True False 1826236.4898311896 2394247.249275888 4945346.886167475 1.0 1.3110280418814777 2.7079444057240387 20.800442169594213 -6.942223914399576 0.6385377377957476 0.9847218542905131 3.110646423757061 0.9984409372685228 0.029327724943317986 0.08676653375567307 0.05009804683689303 0.029054610499517956 0.11910159319908821 1.142289239216088e-07 6.942223914399576 2.125924569466548 up ADQFEYVMYGK(ub)VYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADQFEYVMYGKVYR 14 1 C9JLU1;P52434;P52434-3;P52434-4 C9JLU1 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 1 41796200.0 6410200.0 6568000.0 28818000.0 True False 6206711.709766075 9190636.651667513 21269701.27853143 1.0 1.4807577798734104 3.426887259007727 22.565397706293695 -6.944600295180484 0.6152781708832411 0.9786133711482976 4.031302368293843 0.9987064852074875 0.037736764883062164 0.08572918872876074 0.04551343310356475 0.038169264877829644 0.16441332020428262 1.13605590867823e-07 6.944600295180484 3.052688997145545 up ADQFEYVMYGK(ub)VYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADQFEYVMYGKVYR 14 1 C9JLU1;P52434;P52434-3;P52434-4 C9JLU1 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 1 152360000.0 14877000.0 49364000.0 88119000.0 True False 22569496.654385503 40554608.517307594 70702241.0260702 1.0 1.7968769591247125 3.1326458940913944 24.42787090807051 -6.963345821090464 0.3853962859060287 0.91363454688589 4.063531311268543 0.9998748699918494 0.009842308240906119 0.07852695394020534 0.01686811941744783 0.017299394666203564 0.1125886847023354 1.0880633425047832e-07 6.963345821090464 3.1498967643826528 ADQFEYVMYGK(ub)VYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADQFEYVMYGKVYR 14 1 C9JLU1;P52434;P52434-3;P52434-4 C9JLU1 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 1 15912200.0 1393000.0 2976200.0 11543000.0 True False 1908029.7444095407 2844701.643022725 8816781.135547277 1.0 1.4909105328979275 4.620882437173808 20.863652231117104 -6.93456266887944 0.7083359920123601 0.959495954918465 5.345098495672183 0.9973615086950062 0.08237929477681229 0.09033684112528344 0.06657411680125544 0.0772045006251667 0.276448848009416 1.1626187725123894e-07 6.93456266887944 4.385602540753719 up ADQFEYVMYGK(ub)VYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADQFEYVMYGKVYR 14 1 C9JLU1;P52434;P52434-3;P52434-4 C9JLU1 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 1 34413300.0 6410200.0 8163100.0 19840000.0 True False 5330365.320009624 8119123.760051505 23988452.270204578 1.0 1.5231833603549045 4.5003392506991 22.34580298172797 -6.936965889906507 0.6872077944869561 0.9641873966599601 5.2362608448342325 0.9977389156186236 0.07330574001612707 0.08917842586114687 0.06111924772625044 0.06981287989925139 0.2598475760686415 1.1562030484238071e-07 6.936965889906507 4.272073448174273 up ADQFEYVMYGK(ub)VYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADQFEYVMYGKVYR 14 1 C9JLU1;P52434;P52434-3;P52434-4 C9JLU1 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 1 157575000.0 14877000.0 36078000.0 106620000.0 True False 19258569.769511968 34070227.58488917 87216254.01358427 1.0 1.769094382015085 4.528698395436164 24.19899723016296 -6.947373252093666 0.5869736407900834 0.9678035289179332 5.46812868075349 0.9989786965915523 0.04841800840260462 0.08455797977464997 0.04046208537650044 0.050354637199385446 0.23097947334097627 1.1288253346938196e-07 6.947373252093666 4.500325151835557 ADQQYECVAEIGEGAYGK(ub)VFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADQQYECVAEIGEGAYGKVFK 21 1 Q00534 Q00534 CDK6 Cyclin-dependent kinase 6 1 90767400.0 4970100.0 8218300.0 77579000.0 True False 7540005.062980534 6751680.155129027 62245476.64591631 1.0 0.8954476951584586 8.255362712092255 22.846134061562736 -6.903677958753085 0.9377135786492921 0.7241087192039741 9.088333660689257 0.9883092195169948 0.3724996829648053 0.108748726569052 0.16254079026720386 0.2957422518469448 0.7846972965204544 1.2483088262949324e-07 6.903677958753085 8.364224941485283 up ADQQYECVAEIGEGAYGK(ub)VFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADQQYECVAEIGEGAYGKVFK 21 1 Q00534 Q00534 CDK6 Cyclin-dependent kinase 6 1 10893000.0 3074700.0 1041700.0 6776600.0 True False 2556749.282305327 1036088.1553387389 8193555.728541763 1.0 0.4052365096997451 3.2046770425428397 21.2858792645502 -6.851179163155414 1.2294604880022142 0.6822819894504255 3.3191109464729407 0.9419942312713697 0.2900278858573554 0.15616520669256553 0.4536679937070126 0.18453733323000668 0.4273451991132698 1.4087075325660077e-07 6.851179163155414 2.636828957022515 up ADQQYECVAEIGEGAYGK(ub)VFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADQQYECVAEIGEGAYGKVFK 21 1 Q00534 Q00534 CDK6 Cyclin-dependent kinase 6 1 125139200.0 4970100.0 9249100.0 110920000.0 True False 6433892.4253177 8734379.454387676 90733698.13531014 1.0 1.357557583651452 14.102458066950007 22.617260383655186 -6.9129053513935625 0.8757120857841277 0.6407216697288616 15.856159218440645 0.9919726546779094 0.5459973241301647 0.10252809694407757 0.1285763550868817 0.4535385618491508 1.2786746791627714 1.2220659638877602e-07 6.9129053513935625 15.215437548711783 up ADRDESSPYAAMLAAQDVAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADRDESSPYAAMLAAQDVAQR 21 1 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 21459800.0 6034500.0 2601300.0 12824000.0 False True 5842938.100618291 3640012.6556002907 9465009.688246477 1.0 0.6229764192119561 1.6199058633266892 22.478262574950776 -6.804218161435948 1.4384663405178735 0.7930805149359729 1.635172604984122 0.8442635254548667 0.1621953243414113 0.21478313592269635 0.8768876337719206 0.08868417498865049 0.2057552120648558 1.5695741538098715e-07 6.804218161435948 0.8420920900481491 ADSSPVK(ub)AGVETTTPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADSSPVKAGVETTTPSK 17 1 P0DOY2;P0DOY3 P0DOY2 1 33160960.0 6071950.0 5941110.0 21147900.0 True False 7960385.250847445 5054719.546265394 18959718.172981117 1.0 0.6349842861848024 2.3817588691404987 22.924406822459638 -6.852173204611268 1.224662144421966 0.8048034253318818 2.4545283488792315 0.9433938373950355 0.17898966042839967 0.1550845223109732 0.44651593376850574 0.11430222795300402 0.2648787634106301 1.4054868783733026e-07 6.852173204611268 1.6497249235473497 up ADSSPVK(ub)AGVETTTPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADSSPVKAGVETTTPSK 17 1 P0DOY2;P0DOY3 P0DOY2 1 86450870.0 6918930.0 9631140.0 69900800.0 True False 6699292.354380805 13476904.427731598 51591683.50094964 1.0 2.011690745055897 7.701064645613321 22.675577281201555 -6.937221107098652 0.684927175814189 0.9320367101140357 9.117514841954423 0.9977768080523673 0.1390718152302747 0.08905756639719244 0.0605559942854295 0.13267908833320216 0.49596501088449596 1.155523794551752e-07 6.937221107098652 8.185478131840387 ADSSPVK(ub)AGVETTTPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADSSPVKAGVETTTPSK 17 1 P0DOY2;P0DOY3 P0DOY2 1 321186200.0 9047600.0 49389600.0 262749000.0 True False 13725870.668160124 40575639.9972939 210816544.98302203 1.0 2.956143255190152 15.359065379513794 23.710394330294243 -6.934678288430141 0.7073376632416045 0.8400963207688275 18.237817653721756 0.9973804346429481 0.32542403054413177 0.09028053071927944 0.06630655645835132 0.30520945527346205 1.0948256463561907 1.1623092968588809e-07 6.934678288430141 17.397721332952926 ADSSPVK(ub)AGVETTTPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADSSPVKAGVETTTPSK 17 1 P0DOY2;P0DOY3 P0DOY2 1 40067300.0 6071950.0 5141550.0 28853800.0 True False 8316914.003278901 4914379.320167832 22039126.70266433 1.0 0.5908897600997634 2.6499163865317734 22.98761688398253 -6.855071877658018 1.2103699467723656 0.780335999975972 2.7406419213808992 0.9473641676688176 0.20419234788729598 0.15196669421693587 0.42587682197646726 0.13181664914735033 0.3061902197568661 1.3961372750382352e-07 6.855071877658018 1.9603059214049272 up ADSSPVK(ub)AGVETTTPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADSSPVKAGVETTTPSK 17 1 P0DOY2;P0DOY3 P0DOY2 1 62243250.0 6918930.0 12344600.0 42979720.0 True False 5753396.855569907 12278097.189588742 51966580.73622766 1.0 2.134060538115361 9.032330298216507 22.45598255663583 -6.935545620413058 0.6997765810684236 0.9134815011999962 10.671704887561448 0.9975202731548577 0.17675393695396566 0.08985891944075391 0.06431187312502235 0.16672198698595433 0.6062786681471635 1.1599903586963536e-07 6.935545620413058 9.758223386361452 ADSSPVK(ub)AGVETTTPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADSSPVKAGVETTTPSK 17 1 P0DOY2;P0DOY3 P0DOY2 1 332016600.0 9047600.0 40139300.0 282829700.0 True False 11712296.554858934 37905512.66971953 231357596.67778876 1.0 3.2363860061239778 19.753392991215573 23.481520652386692 -6.931615084119755 0.7334194507863586 0.7632667005742834 23.287992114375157 0.9968461489844531 0.4696757392500006 0.09180797711166204 0.0736366521133475 0.43208230547601617 1.4814561992058521 1.1705363796382384e-07 6.931615084119755 22.524725413800873 ADSTK(ub)CLACESAKPGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADSTKCLACESAKPGTK 17 2 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 3713810.0 1452200.0 1526100.0 735510.0 True False 1903848.263124803 1298411.8286912085 659406.48071011 1.0 0.6819933362547043 0.34635453543331246 20.860487069629322 -7.182483807240867 0.27513795706012945 1.0888088193205991 1.4929044635884457e-13 0.9999524512663797 0.001840291542146041 0.08739841214077143 0.013658227318355004 0.009936198396346364 0.037904599928497006 6.569256096261931e-08 7.182483807240867 -1.08880881932045 down ADSTK(ub)CLACESAKPGTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADSTKCLACESAKPGTK 17 2 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 5056200.0 2110200.0 1089600.0 1856400.0 True False 3201327.676284485 895152.366916343 1489481.7263109756 1.0 0.27961910102100884 0.4652699994896159 21.610238922794984 -10.862136999079414 10.98710008648336 1.0191839270994048 0.372444550261793 0.9384055297785577 0.07579166192288903 0.029707831004497188 0.00037276468706235095 0.06121161293559222 0.024461653700727653 1.373608599029444e-11 10.862136999079414 -0.6467393768376117 ADSTK(ub)NWTEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADSTKNWTEK 10 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9 Q9NR46 SH3GLB2 Endophilin-B2 1 2895680.0 787450.0 803430.0 1304800.0 True False 762452.8307783375 1124243.7888321008 963033.7368390512 1.0 1.4745092987384345 1.2630732000246545 19.540288562285447 -10.105908126341204 4.351260488787373 0.9999570684508824 1.3687912493718926 0.8022311650880876 0.0863184259852561 12799544.982481115 14863630.043404574 4634.301701160145 0.029549093195956277 7.835953924232654e-11 10.105908126341204 0.36883418092101017 ADSTK(ub)NWTEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADSTKNWTEK 10 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9 Q9NR46 SH3GLB2 Endophilin-B2 1 1751710.0 481230.0 365960.0 904520.0 True False 659153.7357517603 349790.67713211366 690891.0051741523 1.0 0.5306663046264614 1.048148508763583 19.330255461582055 -6.667965348317113 1.9452596403320008 0.69989559503272 1.0460099646195091 0.2698492873548042 0.19945800809500228 0.4657605158046595 3.396068324441143 0.0826178700450698 0.2212672544350429 2.148001853028565e-07 6.667965348317113 0.3461143695867891 ADSTK(ub)NWTEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADSTKNWTEK 10 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9 Q9NR46 SH3GLB2 Endophilin-B2 1 2765460.0 787450.0 1096400.0 881610.0 True False 654799.5649498582 1090493.4755816392 1065950.57489592 1.0 1.6653851559372135 1.6279036089120584 19.320693837719723 -10.143747339943285 4.723546289355688 0.9999416428501928 1.6466443824303594 0.9974865377503523 0.01530177751670931 10697495.006890658 0.7860442346118726 6790.206941908255 0.005238205444423305 7.18212004870211e-11 10.143747339943285 0.6467027395801666 ADTPSLGEGPEK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADTPSLGEGPEKTR 14 1 Q15833;Q15833-2;Q15833-3;M0R0M7 Q15833 STXBP2 Syntaxin-binding protein 2 1 7582300.0 2256600.0 1878400.0 3447300.0 True False 2184965.4682003916 2628454.915726595 2544348.713216784 1.0 1.202973206661923 1.164480057120716 21.059179048478093 -10.134254154658514 4.591517320431004 0.9999805425883072 1.1837266318948072 0.9681274704324232 0.01571476250667124 10975931.748281354 0.07786807796641042 2257.8718115142915 0.005379581192432711 7.340841470439667e-11 10.134254154658514 0.18374608930650005 ADTPSLGEGPEK(ub)TR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADTPSLGEGPEKTR 14 1 Q15833;Q15833-2;Q15833-3;M0R0M7 Q15833 STXBP2 Syntaxin-binding protein 2 1 4698100.0 1072900.0 1525500.0 2099700.0 True False 1469580.1240323016 1458098.3658461012 1603794.1046789077 1.0 0.9921870485328175 1.0913281136916466 20.486972588669182 -6.887847624160189 1.0350679753164758 0.9943948978264191 1.0995029393902274 0.9794831185518122 0.006446697903003832 0.12090536022081824 0.2322064489880121 0.004758647120337801 0.011774682342976878 1.294650000519122e-07 6.887847624160189 0.10510804156380826 ADTPSLGEGPEK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADTPSLGEGPEKTR 14 1 Q15833;Q15833-2;Q15833-3;M0R0M7 Q15833 STXBP2 Syntaxin-binding protein 2 1 7015300.0 2256600.0 2943400.0 1815300.0 True False 1876462.8843302452 2927543.3199808416 2194870.837001128 1.0 1.5601392089488368 1.1696851855316768 20.83958432391237 -10.228877744780581 4.420190150164696 0.999857543792056 1.364912197246445 0.5380202549167761 0.15940218758574443 0.00022386537668631656 3.9054402648109884e-05 0.1544004233590558 0.051446834819453176 5.903672469606637e-11 10.228877744780581 0.36505465345438903 ADTPSLGEGPEK(ub)TR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADTPSLGEGPEKTR 14 1 Q15833;Q15833-2;Q15833-3;M0R0M7 Q15833 STXBP2 Syntaxin-binding protein 2 1 24151800.0 3629200.0 3720800.0 16801800.0 True False 4698070.942227121 3513734.209153932 13744044.80102646 1.0 0.7479099937746461 2.925465573006246 22.163637067950255 -6.878074432244055 1.0905293111114254 0.8474187612489995 3.074172115984297 0.9720966433316385 0.16245797138136972 0.1293471991467706 0.2827359016062666 0.1149516367849958 0.27666191471369095 1.3241145802830932e-07 6.878074432244055 2.2267533547352976 up ADTQTYQPYNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADTQTYQPYNK 11 0 P84090 P84090 ERH Enhancer of rudimentary homolog 0 17932700.0 5266200.0 1806500.0 10860000.0 False True 5099027.363572146 2527844.8707730495 8015440.206983528 1.0 0.495750403073373 1.5719547347885336 22.28179064943301 -6.7793222927859045 1.5387231165522777 0.714223118645842 1.5802648214083772 0.7648891466329744 0.21317768202192064 0.25164323592880344 1.176825626061334 0.10912807024827713 0.2576199044722947 1.6621786788488328e-07 6.7793222927859045 0.8660417027625352 ADTSLNNCEGAAGSTSEK(ub)SR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADTSLNNCEGAAGSTSEKSR 20 1 O76080;Q5QPB1 O76080 ZFAND5 AN1-type zinc finger protein 5 1 18669300.0 5406500.0 10478000.0 2784800.0 True False 6998820.8280477505 9894890.089097755 2277994.9744609785 1.0 1.413793885027606 0.325482682072946 22.73868044440621 -6.803653789011866 1.4408505724074319 1.227257165519823 0.3090480525997566 0.8426744018153908 0.17790662849820527 0.21557118127041056 0.8831112037701726 0.09711783699442375 0.22538664539352812 1.571615165675236e-07 6.803653789011866 -0.9182091129200665 down ADVDVSGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADVDVSGPK 9 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7192710.0 2198400.0 648510.0 4345800.0 False True 2128612.9953433177 907463.4249349744 3207504.6087945667 1.0 0.4263167738429654 1.506851934011254 21.021482245534727 -6.762444039248921 1.6031317575451438 0.6677952395074106 1.5113058157872652 0.7009515223541536 0.2413852865029312 0.2788125925976694 1.412765293503735 0.11876846112514258 0.28475062499250176 1.7280486328172845e-07 6.762444039248921 0.8435105762798546 ADVFHAYLSLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADVFHAYLSLLK 12 0 Q86VP6;Q86VP6-2;A0A0C4DGH5;H0YH27;Q86VP6-3 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 34836600.0 7962900.0 13175900.0 13697800.0 False True 10439439.012833297 11210107.079255925 12280483.054575661 1.0 1.0738227471299213 1.1763546910403089 23.315540851679803 -6.966505693194658 0.3312157687706731 0.9876840942963993 1.2658558624742462 0.9999408780457255 0.0005559966547989411 0.07745386526222436 0.013079491867513638 0.0014896907511874249 0.008934335361511782 1.080175460698589e-07 6.966505693194658 0.27817176817784695 ADVFHAYLSLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADVFHAYLSLLK 12 0 Q86VP6;Q86VP6-2;A0A0C4DGH5;H0YH27;Q86VP6-3 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 50996400.0 21476400.0 13714200.0 15805800.0 False True 20794643.437587 19190351.578608204 11665786.81616391 1.0 0.9228507156761829 0.5609996079604624 24.30970861174761 -6.941242260667895 0.6479131459504368 1.003990665832268 0.45975062120958465 0.9983220016296586 0.007839246274190527 0.08720473935731533 0.05206494063176266 0.007704686575581854 0.030977377504333322 1.1448741229609654e-07 6.941242260667895 -0.5442400446226833 ADVFHAYLSLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ADVFHAYLSLLK 12 0 Q86VP6;Q86VP6-2;A0A0C4DGH5;H0YH27;Q86VP6-3 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 293371000.0 84904000.0 89579000.0 118888000.0 False True 128805575.3138366 73592927.5660784 95389734.6895386 1.0 0.5713489294758257 0.740571473378541 26.940619800560288 -10.265166473661731 6.658627690334028 1.000004401750129 0.6559602014271834 0.8464165310328567 0.06908481425622966 4.514375423106571e-06 4.982683293758941e-07 0.06689193918598463 0.022297027924184164 5.430421328051789e-11 10.265166473661731 -0.3440442003229457 ADVFHAYLSLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADVFHAYLSLLK 12 0 Q86VP6;Q86VP6-2;A0A0C4DGH5;H0YH27;Q86VP6-3 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 46169800.0 7962900.0 12790200.0 25416700.0 False True 10906999.319281217 12225086.672464645 19413798.93336784 1.0 1.1208478440860754 1.779939501696717 23.378750913202694 -6.937887380095603 0.6789370344823508 0.9922619598126476 1.9471456676952383 0.9978738435953202 0.01580439326260955 0.0887438188686034 0.05909946356498347 0.015148445703664158 0.05727475257146204 1.1537524065447308e-07 6.937887380095603 0.9548837078825907 ADVFHAYLSLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADVFHAYLSLLK 12 0 Q86VP6;Q86VP6-2;A0A0C4DGH5;H0YH27;Q86VP6-3 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 48898800.0 21476400.0 11012500.0 16409900.0 False True 17858578.165837996 10953173.476689907 19841134.21919509 1.0 0.613328417020479 1.1110142159665075 24.090113887181886 -6.6993257873735965 1.8329759725399852 0.7597292353907229 1.1095263197540148 0.4143860439448137 0.16324031851592244 0.3969960635568907 2.59261145549937 0.07105576250775841 0.18290913907470524 1.9983622295020244e-07 6.6993257873735965 0.34979708436329193 ADVFHAYLSLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ADVFHAYLSLLK 12 0 Q86VP6;Q86VP6-2;A0A0C4DGH5;H0YH27;Q86VP6-3 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 177992000.0 84904000.0 25864000.0 67224000.0 False True 109909901.70804895 24424645.66371679 54989921.7764883 1.0 0.22222425172024438 0.5003181780887832 26.711746122652738 -10.383145544917147 5.869097532838486 1.0001530867235497 0.36127121491240893 0.8755255742258228 0.11353137002834207 0.00022747252208948714 2.3907649271051785e-05 0.10995214760185741 0.036642092115989656 4.13860954538214e-11 10.383145544917147 -0.6388818718111409 ADVILK(ub)YNADEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADVILKYNADEAR 13 1 O14602;A6NJH9;P47813;X6RAC9 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 1 16422000.0 4521170.0 6522830.0 5378000.0 True False 5927297.653072565 5549649.189792199 4821536.149418742 1.0 0.9362865701396652 0.8134459295998704 22.498943076944308 -6.9607553975800975 0.4246540114832405 1.0051652985868822 0.7398977851430648 0.9997971910411687 0.0011026018255062269 0.07943237203350605 0.020142417449915878 0.0015943344428562766 0.010212880604764387 1.0945726756057668e-07 6.9607553975800975 -0.2652675134438174 ADVILK(ub)YNADEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADVILKYNADEAR 13 1 O14602;A6NJH9;P47813;X6RAC9 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 1 21083060.0 5968760.0 9672600.0 5441700.0 True False 5779284.980934045 13534919.621942637 4016355.5224992805 1.0 2.3419713107407847 0.694957167841576 22.4624595813805 -6.690064026247799 1.8661469007052196 1.841297643265626 0.7006533445322972 0.3706684951098812 0.5675556316443447 0.41657615482855487 2.812748811572012 0.24329410399530063 0.633513290038401 2.0414369618355412e-07 6.690064026247799 -1.1406442987333287 ADVILK(ub)YNADEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADVILKYNADEAR 13 1 O14602;A6NJH9;P47813;X6RAC9 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 1 21524760.0 5968760.0 12599100.0 2956900.0 True False 4963288.400901795 12531226.147574456 3575174.1188391075 1.0 2.5247829937300477 0.7203236705305142 22.242864856814776 -6.682723433680165 1.8922727753269701 1.9623766050508828 0.7270469174738988 0.33662970401570735 0.6458570516309856 0.43248659276142987 2.9963861477547806 0.273643387215276 0.7191914616668806 2.0762352794791776e-07 6.682723433680165 -1.235329687576984 ADVIQATGDAICIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADVIQATGDAICIFR 15 0 Q08945;E9PMD4 Q08945 SSRP1 FACT complex subunit SSRP1 0 11263700.0 1682300.0 6113500.0 3467900.0 False True 2205511.5914163757 5201389.630236355 3109074.9744457523 1.0 2.358359688735996 1.4096842594461767 21.0726819120871 -10.241377625190607 6.001763657308375 0.9999752622690933 1.8840219740910853 0.5365627337015957 0.38729512221265283 0.00012821123166647386 1.620567680140332e-05 0.3750073394305113 0.12499896319974567 5.736174767973862e-11 10.241377625190607 0.884046711821992 ADVIQATGDAICIFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADVIQATGDAICIFR 15 0 Q08945;E9PMD4 Q08945 SSRP1 FACT complex subunit SSRP1 0 8151600.0 4927500.0 1289800.0 1934300.0 False True 4771079.209677137 1804823.8662181422 1427648.8022438507 1.0 0.3782841966986073 0.29922974226631227 22.18588420753484 -13.999999999999998 0.29078416331639556 6.381051407117098 0.27785683632892927 0.9996292174476828 0.006034339082428871 16.012481523637803 0.17102145157599175 51.56703364792736 0.029751442007644815 1.0000000000000041e-14 13.999999999999998 -6.103194570788168 ADVIQATGDAICIFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADVIQATGDAICIFR 15 0 Q08945;E9PMD4 Q08945 SSRP1 FACT complex subunit SSRP1 0 13994000.0 1682300.0 5905800.0 6405900.0 False True 2304291.772448077 5644862.228131047 4892958.353651774 1.0 2.4497167831024944 2.123410937866389 21.13589197360999 -10.523114845321533 5.168724151143726 0.9955889345566373 2.2865638604844487 0.95397586217179 0.13321380348605383 0.006775777642489927 0.000625157223721403 0.12906728070976606 0.04299457019886259 2.9983695219311226e-11 10.523114845321533 1.2909749259278114 ADVQSIIGLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADVQSIIGLQR 11 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 17919400.0 3151700.0 6615100.0 8152600.0 False True 4131909.2211062177 5628152.865457839 7309047.157261291 1.0 1.3621191958208219 1.7689273326543393 21.978377127569125 -6.969616540970708 0.26718450315936376 0.8953558066330141 2.2478748322451225 0.9999792358008837 0.0014312255673925452 0.07642731519477812 0.009474393031895827 0.008114101855734853 0.03798406590123653 1.0724658178401832e-07 6.969616540970708 1.3525190256121085 ADVQSIIGLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADVQSIIGLQR 11 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 12353400.0 4210900.0 1485100.0 6657400.0 False True 4077227.2844301225 2078108.1746941912 4913627.222281042 1.0 0.5096866153697022 1.2051393948639837 21.95915695121333 -6.717236150086347 1.7691595976215004 0.7008338968839881 1.2039020103347249 0.4995748883863761 0.20639704832962869 0.3606710077051447 2.2046341786496693 0.09268608686436125 0.23344538688992747 1.917625737261723e-07 6.717236150086347 0.5030681134507368 ADVQSIIGLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADVQSIIGLQR 11 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 13645300.0 3151700.0 4995300.0 5498300.0 False True 4316968.661489986 4774591.128751908 4199714.781043029 1.0 1.1060055106130828 0.9728388390925945 22.041587189092017 -6.694616615028402 1.8498304494166213 1.0661680349592366 0.9732693072033154 0.3922027873535491 0.04479161268887345 0.40681782673613925 2.7023920244776627 0.01934466643142001 0.0500870380671657 2.0201489167994014e-07 6.694616615028402 -0.09289872775592123 ADWLSHYWMPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADWLSHYWMPK 11 0 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 20055600.0 5191800.0 4700400.0 10163400.0 False True 6806500.077462721 3999118.642015699 9111788.862216877 1.0 0.5875440529645101 1.3386893055929423 22.698481720152788 -6.757619278990785 1.6213328855609699 0.7597116948646708 1.3411230346012992 0.6811826410027255 0.17342681236876026 0.2869509279324809 1.4861020950737918 0.0844172605028999 0.20335574940527937 1.7473532858828967e-07 6.757619278990785 0.5814113397366284 ADWLSHYWMPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ADWLSHYWMPK 11 0 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 20399300.0 5191800.0 7331100.0 7876400.0 False True 7111348.763119492 7007187.761294241 6016156.539549913 1.0 0.985352848623394 0.8459937404210285 22.76169178167568 -6.927020842225165 0.7708505684338622 1.0023697309711532 0.8194397129509188 0.9959196807317613 0.0044334026201368415 0.09421452058510711 0.08547585114207623 0.003969640755888438 0.012822358098462843 1.18298478174378e-07 6.927020842225165 -0.18293001802023445 ADWLSHYWMPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ADWLSHYWMPK 11 0 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 13961400.0 6242100.0 3235500.0 4483800.0 False True 5190582.721916959 3218069.719303531 5421341.849251172 1.0 0.6199823587658864 1.0444572680365627 22.307465081477257 -6.670678375990902 1.9348032474266952 0.7575786458922911 1.0427523446986071 0.282100399053676 0.16139792600095326 0.4595774934267302 3.317392743880871 0.06713816293161258 0.17922859202812508 2.1346251601367405e-07 6.670678375990902 0.28517369880631604 ADYEIASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ADYEIASK 8 0 A8MYV2;Q9NQ29-2;Q9NQ29-3;Q9NQ29;B8ZZ12;Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 A8MYV2;Q9Y383 LUC7L;LUC7L2 Putative RNA-binding protein Luc7-like 1;Putative RNA-binding protein Luc7-like 2 0 3900560.0 143660.0 1835900.0 1921000.0 False True 188339.65120541913 1561990.8762821495 1722233.347533173 1.0 8.293478650326852 9.144295088742412 17.522977237401964 -9.553732035076628 0.6198632497368323 1.345740364550849e-16 9.046794335182765 0.9989465907331752 0.11863606025430838 0.8651084476806485 0.2853929925328825 2.2419713539536636 0.14335286171142 2.7942674060794765e-10 9.553732035076628 9.046794335182765 ADYEIASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ADYEIASK 8 0 A8MYV2;Q9NQ29-2;Q9NQ29-3;Q9NQ29;B8ZZ12;Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 A8MYV2;Q9Y383 LUC7L;LUC7L2 Putative RNA-binding protein Luc7-like 1;Putative RNA-binding protein Luc7-like 2 0 4768980.0 1617200.0 518580.0 2633200.0 False True 1565862.8712105246 725651.6983589737 1943485.9256932768 1.0 0.463419697663559 1.2411597218540742 20.578526444988324 -6.721113521373819 1.7556850740451793 0.6739338704741233 1.2399929557480547 0.5176158149343822 0.2257644111550968 0.3531492797341603 2.128068653743935 0.10208747770172054 0.2559062790892735 1.9005814170259864e-07 6.721113521373819 0.5660590852739313 AEAAEK(ub)GDVGLVAENSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEAAEKGDVGLVAENSR 17 1 P18858;M0R0Q7;F5GZ28;P18858-2;P18858-3 P18858 LIG1 DNA ligase 1;DNA ligase 1 2612710.0 700700.0 1361900.0 550110.0 True False 918624.4855884521 1158709.8286446198 493189.89422773215 1.0 1.2613530847725813 0.5368786723682907 19.809115712999194 -6.8091362913254265 1.41832234792561 1.1425783932539408 0.5244707261549678 0.8575286613730901 0.11307174348592325 0.20797556679636614 0.8247620711567494 0.06269146016077506 0.14506494262249542 1.5518999126159109e-07 6.8091362913254265 -0.618107667098973 AEAAEK(ub)GDVGLVAENSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEAAEKGDVGLVAENSR 17 1 P18858;M0R0Q7;F5GZ28;P18858-2;P18858-3 P18858 LIG1 DNA ligase 1;DNA ligase 1 4442960.0 962160.0 1177300.0 2303500.0 True False 931616.7574597574 1647402.0295383944 1700144.246481264 1.0 1.7683258876003596 1.8249395289078454 19.829377064701195 -11.185250884971914 0.4508941675051176 7.532513453061008e-23 1.8253215424877371 0.9997183629348753 0.0063141887063506525 3.215074165606839 0.22099030363364236 3.258965512703148 0.012735283350185636 6.527533585396466e-12 11.185250884971914 1.8253215424877371 AEAAEK(ub)GDVGLVAENSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEAAEKGDVGLVAENSR 17 1 P18858;M0R0Q7;F5GZ28;P18858-2;P18858-3 P18858 LIG1 DNA ligase 1;DNA ligase 1 16581400.0 2490900.0 3068500.0 11022000.0 True False 3224519.152979588 2897735.2775717187 9016109.095270358 1.0 0.8986565562478028 2.7961096422513423 21.62065260820631 -6.894289678620384 0.9966863810512516 0.9082823153636675 2.973695711727981 0.983504069795042 0.11194056818640628 0.11573067196405375 0.20208079401016052 0.0850594185590569 0.215599940162325 1.2755876956607095e-07 6.894289678620384 2.0654133963643138 up AEACFVNCVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEACFVNCVER 11 0 O60220 O60220 TIMM8A Mitochondrial import inner membrane translocase subunit Tim8 A 0 8025100.0 1721800.0 3164500.0 3138800.0 False True 2358395.9898954364 3024681.926397894 2397480.0856151646 1.0 1.2825165660716709 1.0165723211399544 21.169374545781732 -10.60058553279054 2.7811276209764486 0.9884487606933723 1.1495444430622817 0.29656597746592395 0.10857128883453433 42316558.38993098 39971972.76575956 3564480.397156043 0.03899137899849889 2.508502090034136e-11 10.60058553279054 0.16109568236890937 AEAEK(ub)QLQQAQAAGAEQEVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEAEKQLQQAQAAGAEQEVEK 21 1 P39748;P39748-2;F5H1Y3 P39748 FEN1 Flap endonuclease 1 1 6681300.0 2264000.0 1930500.0 2486800.0 True False 2968125.9246071875 1642476.925030063 2229489.7910700105 1.0 0.5533717122353676 0.7511439365110728 21.50112086982484 -10.276065678703224 5.646928945023672 1.0000283956421023 0.6522578243732147 0.8047691491776318 0.0807401724618123 2.8866290817888527e-05 3.70066310002082e-06 0.07818270795108298 0.026058778609539906 5.295833485203298e-11 10.276065678703224 -0.34777057126888766 AEAEK(ub)QLQQAQAAGAEQEVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEAEKQLQQAQAAGAEQEVEK 21 1 P39748;P39748-2;F5H1Y3 P39748 FEN1 Flap endonuclease 1 1 8495300.0 2179000.0 2554000.0 3762300.0 True False 2109828.837724295 3573825.5189340548 2776840.763419346 1.0 1.6938935780159574 1.3161450416112919 21.008694532719897 -10.146991992386093 4.493444360905842 0.9999295769948533 1.5050193098275038 0.7044163993367353 0.15421519427422964 17681605.08974944 39928205.35613612 7754.504475429218 0.05279196662564387 7.12866173983282e-11 10.146991992386093 0.5050897328326505 AEAEK(ub)QLQQAQAAGAEQEVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEAEKQLQQAQAAGAEQEVEK 21 1 P39748;P39748-2;F5H1Y3 P39748 FEN1 Flap endonuclease 1 1 5753700.0 2264000.0 1689200.0 1800500.0 True False 3101061.9822994964 1614565.5585625912 1375258.9824614832 1.0 0.5206492381572329 0.4434800046923611 21.564330931347733 -13.999999999999998 0.25704871972554727 4.455746666148447 0.4144675617058901 0.9995563715125795 0.005185186337647679 14.28862355168045 0.1604321663345545 25.60364642906592 0.03427000894716315 1.0000000000000041e-14 13.999999999999998 -4.041279104442557 AEAEK(ub)QLQQAQAAGAEQEVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEAEKQLQQAQAAGAEQEVEK 21 1 P39748;P39748-2;F5H1Y3 P39748 FEN1 Flap endonuclease 1 1 6695900.0 2179000.0 2770000.0 1746900.0 True False 1811935.0460673564 2755077.460198052 2112168.713246994 1.0 1.5205166797660339 1.1656978089977719 20.789099808154173 -10.531602453683435 5.842117102501418 0.9993704988084552 1.343107244381902 0.5549159022997093 0.14485419741546157 0.0011897741981480065 9.539121548180109e-05 0.14050168448169845 0.04675149118486029 2.9403399612490525e-11 10.531602453683435 0.3437367455734469 AEAGAGSATEFQFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEAGAGSATEFQFR 14 0 P46783;Q9NQ39 P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 AEAGDNLGALVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEAGDNLGALVR 12 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 27699200.0 1477500.0 16767000.0 9454700.0 False True 1937016.8081303537 14265428.957254106 8476418.339886453 1.0 7.364638704928625 4.376016926806153 20.885405042057855 -9.663928305816782 10.799373769580354 1.000000000252421 5.870327817291766 0.7797791606277084 1.2200997317615698 0.0 0.0 1.1813564854561742 0.393785495152058 2.1680619831954878e-10 9.663928305816782 4.870327817039345 AEAGDNLGALVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEAGDNLGALVR 12 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 16462700.0 5205400.0 3061500.0 8195800.0 False True 5040157.426291904 4283972.915511588 6049074.111270307 1.0 0.849968077021624 1.200175629379234 22.265037365466757 -6.790292533111629 1.495210988010343 0.9161799322337837 1.2039281957728174 0.802266164503963 0.06379244735478433 0.2349101655367562 1.037509485667461 0.03358179728927794 0.07860489393365251 1.6207180424860804e-07 6.790292533111629 0.2877482635390337 AEAGDNLGALVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEAGDNLGALVR 12 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 23251200.0 1477500.0 9926700.0 11847000.0 False True 2023771.6779361782 9488105.570792854 9048982.596623808 1.0 4.688328072892456 4.471345604486307 20.948615103580746 -10.260171971258623 4.351726081840446 0.9978409329247085 4.579836838752635 0.9972521749104949 0.08858272200115674 2386964.9979123333 5629498.575460555 30939.929174285393 0.030324221920812768 5.493233105886209e-11 10.260171971258623 3.581995905827926 AEAGVPAEFSIWTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEAGVPAEFSIWTR 14 0 P21333-2;P21333;Q60FE5;H0Y5C6 P21333-2 FLNA Filamin-A 0 9292400.0 2694700.0 2926800.0 3670900.0 False True 3532777.7955119195 2490132.8485770468 3291070.4817592474 1.0 0.704865404141902 0.9315815124122044 21.752371578843 -9.816077373285985 5.558316315478022 1.0000000477442368 0.8182234590394685 0.4615364254619527 0.0925564636279432 30404948.011917543 53695642.519229524 11.596421078720674 0.031684536030676606 1.5272939334874617e-10 9.816077373285985 -0.18177658870476832 AEAGVPAEFSIWTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEAGVPAEFSIWTR 14 0 P21333-2;P21333;Q60FE5;H0Y5C6 P21333-2 FLNA Filamin-A 0 10637000.0 2694700.0 3136100.0 4806200.0 False True 3691003.411529351 2997536.7323041335 3671074.5467961016 1.0 0.8121197403776219 0.9946006918685041 21.81558164036589 -10.695016866265496 8.274983079357991 1.000289351460546 0.9033602161273698 0.27217239913313407 0.07449753648837176 0.00039886146239718253 1.47003757187396e-05 0.07234573592124847 0.02404397651274527 2.0182879799043068e-11 10.695016866265496 -0.09692913533317615 AEAIK(ub)ALVKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEAIKALVKPK 11 2 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 6094700.0 1667900.0 2034400.0 2392400.0 True False 2186633.0519665736 1730875.4500290889 2144857.397521267 1.0 0.7915710633169137 0.9808949862860004 21.06027970533637 -10.370444540515916 7.151823943063732 1.0000035772261928 0.8862330248270538 0.3249901899467451 0.07729116789604171 4.4086644013802184e-06 3.8812445814708344e-07 0.07483920430466433 0.02494561717252422 4.2614309865927305e-11 10.370444540515916 -0.11377055239913902 AEAIK(ub)ALVKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEAIKALVKPK 11 2 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 14491200.0 2394100.0 5264100.0 6833000.0 True False 2318100.605964085 7366082.581918845 5043232.314393958 1.0 3.1776371409278554 2.1755881955332588 21.14451175023965 -10.637723085727146 6.987423169783671 0.9950677187065309 2.6766126682301823 0.7887053755417414 0.4090847689184613 0.03132745496559357 0.0016242330079802127 0.39476733051731533 0.13203154143402576 2.302909727628407e-11 10.637723085727146 1.6815449495236514 AEAIK(ub)ALVKPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEAIKALVKPK 11 2 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 8282100.0 2410900.0 2106500.0 3764700.0 True False 3657511.560399139 1730578.61684038 3020605.394873372 1.0 0.4731573880935388 0.8258635263325695 21.80243099366173 -9.943143392951196 5.583190471187917 1.000000440598817 0.6495104572124851 0.5683379739238923 0.14399167797422135 7.897912940493058e-07 1.495849327008015e-07 0.1394195192796528 0.046473114231924025 1.1398733683351962e-10 9.943143392951196 -0.35048998338633186 AEAIK(ub)ALVKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEAIKALVKPK 11 2 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 4753800.0 1667900.0 1268600.0 1817300.0 True False 2284567.703302705 1212549.0573007974 1388091.168468344 1.0 0.5307564558265729 0.6075946738026796 21.12348976685926 -10.730055775207962 6.897544215547423 1.0059203596388975 0.5691755648147023 0.976698927944602 0.03136907113103522 0.0028697843562765562 0.00011231253627716958 0.030520415716070098 0.01012432417304126 1.8618480094512856e-11 10.730055775207962 -0.43674479482419515 AEAIK(ub)ALVKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEAIKALVKPK 11 2 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 12092300.0 2394100.0 8294000.0 1404200.0 True False 1990800.2266130627 8249318.575769899 1697811.727712768 1.0 4.14371993005266 0.8528287796115261 20.924917025673928 -6.656545493242053 1.9851420223124518 3.0293024524705032 0.8666163249322464 0.22102852563442832 1.3396376416950513 0.49268758674191515 3.728653179545153 0.545905864290291 1.484559028697428 2.2052331215788884e-07 6.656545493242053 -2.1626861275382567 AEANQHVVDEK(ub)AR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEANQHVVDEKAR 13 1 P49795 P49795 RGS19 Regulator of G-protein signaling 19 1 4768800.0 1104300.0 1079100.0 2585400.0 True False 1675303.8351440427 886526.1739532177 2074394.5567789238 1.0 0.529173368648675 1.2382199057047865 20.67599133755374 -6.727708765980692 1.7318907897945133 0.7159348079604888 1.2376015010789823 0.5484989460957177 0.19796201309402256 0.3405382091064344 2.0000521638611244 0.09062725200702368 0.22544477894310092 1.8719370238912864e-07 6.727708765980692 0.5216666931184935 AEANQHVVDEK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEANQHVVDEKAR 13 1 P49795 P49795 RGS19 Regulator of G-protein signaling 19 1 5523920.0 1104300.0 932420.0 3487200.0 True False 1429538.1190073318 880530.0073369474 2852565.3816935946 1.0 0.6159541992125299 1.9954454825411791 20.44711765964619 -6.83241650064895 1.3170260895255428 0.7951063050303094 2.0344457412257033 0.9106273651229064 0.17378717821535186 0.17785101898428213 0.602464318283588 0.10357653882351738 0.2383633171384267 1.4709011900973528e-07 6.83241650064895 1.2393394361953938 AEASSGDHPTDTEMK(ub)EEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEASSGDHPTDTEMKEEQK 19 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 1 10111100.0 3183300.0 4246900.0 2680900.0 True False 4829298.830402996 3489007.5138188526 2151018.939919789 1.0 0.722466684367035 0.44541019627486794 22.203382307591752 -6.971146562883022 0.22915387834785608 1.1138770029015739 0.046091584417886244 0.9999899958214322 0.0007160987438449977 0.0759324217912994 0.0076857560938256245 0.0071634579574658425 0.02756262032655328 1.0686941623901878e-07 6.971146562883022 -1.0677854184836877 down AEASSGDHPTDTEMK(ub)EEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEASSGDHPTDTEMKEEQK 19 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 1 2361860.0 1297300.0 579530.0 485030.0 True False 1776946.8682142831 553924.4483505677 370475.90350641083 1.0 0.31172819978980354 0.2084901412267409 20.760969113881682 -13.999999999999998 0.26712796141018763 6.231362855197373 0.1732564195423681 0.999577190813712 0.00722405867985983 14.744278116136938 0.16359015058408702 41.81574721182776 0.04350151045257657 1.0000000000000041e-14 13.999999999999998 -6.058106435655005 AEASSGDHPTDTEMKEEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEASSGDHPTDTEMKEEQK 19 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 12113700.0 3550900.0 1214700.0 7348100.0 False True 3438178.623164388 1699736.0445768174 5423412.171725191 1.0 0.4943710699394773 1.5774084962268944 21.713213068200428 -6.779780573784932 1.5369330447484069 0.7136119785028814 1.5858946369693472 0.7665194962681042 0.21380155501751086 0.25092974084643777 1.1707901590164869 0.10957132087090624 0.2585673667981768 1.6604256214876564e-07 6.779780573784932 0.8722826584664658 AECK(ub)MLLNS ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AECKMLLNS 9 1 E7EQY4;Q9BTC8-2 E7EQY4 MTA3 Metastasis-associated protein MTA3 1 4251200.0 2688800.0 1562400.0 0.0 True False 3682922.022087845 1493368.0018341206 0.0 1.0 0.4054845562512159 0.0 21.81241942093649 -8.259114989134904 0.539875028085921 1.0307535242284138 3.9401261815525093e-19 0.9916911297762377 0.03743402214226833 0.1407996014091718 0.17536155697032407 0.05737688387126827 0.07188860493643422 5.5066187710776185e-09 8.259114989134904 -1.0307535242284138 AECMLQQAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AECMLQQAER 10 0 P13796 P13796 LCP1 Plastin-2 0 9552300.0 4236900.0 1058500.0 4256900.0 False True 4102401.928661807 1481164.5700045794 3141890.1857373975 1.0 0.36104813613124725 0.7658660073715093 21.9680374146477 -10.159741479215354 5.443252907030088 1.0000116489553688 0.5634570717514458 0.6079208534760017 0.1652662038833698 2.3363785760487306e-05 3.606502126446407e-06 0.16002257978397177 0.0533394379442223 6.922429170429008e-11 10.159741479215354 -0.436554577203923 AEDFQIEGYNPHPTIK(ub)MEMAV ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEDFQIEGYNPHPTIKMEMAV 21 1 P04818;P04818-2;P04818-3 P04818 TYMS Thymidylate synthase 1 39176700.0 19147000.0 12448000.0 7581700.0 True False 24786168.94379549 11755257.857328566 6201908.3948114 1.0 0.4742668334095721 0.25021649811532776 24.563031963756078 -11.086420141731084 0.164440813844621 2.032551572509566 2.421792823356472e-21 0.9995676202254582 0.0065344007026621916 3.3284405847189347 0.09558743250046517 1.4693873105918995 0.18269609524101668 8.195583100843577e-12 11.086420141731084 -2.032551572509566 AEDGENYDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEDGENYDIK 10 0 E5RJD8;O75347;E5RIW3;E5RHG6;O75347-2;E5RIX8;A0A494C144 E5RJD8 TBCA Tubulin-specific chaperone A 0 14629600.0 3231100.0 1654200.0 9744300.0 False True 3128530.499114721 2314730.6865390413 7191975.507266076 1.0 0.7398779354057886 2.298835031111631 21.57705373783548 -6.864021944705661 1.1653422591976668 0.8570734509890511 2.3803020517691356 0.9583389088587166 0.13918451552818106 0.14271052159169795 0.366022877437275 0.09299533981712761 0.2181445291507936 1.3676597166168993e-07 6.864021944705661 1.5232286007800844 up AEDGENYDIKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEDGENYDIKK 11 1 E5RJD8;O75347;E5RIW3;E5RHG6;O75347-2;E5RIX8;A0A494C144 E5RJD8 TBCA Tubulin-specific chaperone A 1 11897010.0 6738500.0 2822600.0 2335910.0 True False 8834238.755726827 2401479.082408624 2094212.440830929 1.0 0.2718376929593233 0.2370563552488717 23.074674392765 -13.44088737529973 0.43900492075941894 9.999995581290001 0.23668345507358554 0.9998783700810588 0.0038792354221751086 19.98536424686864 0.2232347785407521 170.64906992999983 0.008057084540700952 3.6233695033468545e-14 13.44088737529973 -9.763312126216416 AEDGENYDIKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEDGENYDIKK 11 1 E5RJD8;O75347;E5RIW3;E5RHG6;O75347-2;E5RIX8;A0A494C144 E5RJD8 TBCA Tubulin-specific chaperone A 1 9370200.0 3505500.0 4276700.0 1588000.0 True False 3394219.8213136857 5984408.612695878 1172055.1610211642 1.0 1.7631175727386141 0.3453091498851528 21.694648571107972 -6.760498713312279 1.6104738345305447 1.4429821081612886 0.3399791034761799 0.693053428015628 0.32099349413812317 0.2820767613632919 1.4420087315597412 0.1572497403842182 0.37772799316714245 1.735806405551298e-07 6.760498713312279 -1.1030030046851087 AEDGENYDIKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEDGENYDIKK 11 1 E5RJD8;O75347;E5RIW3;E5RHG6;O75347-2;E5RIX8;A0A494C144 E5RJD8 TBCA Tubulin-specific chaperone A 1 10940610.0 6551400.0 3411200.0 978010.0 True False 9938952.771495683 2802444.70817275 784705.8948229895 1.0 0.2819657938419823 0.07895257305915354 23.24466241799682 -10.59630663468369 0.2706357601224101 1.7771262564496006 6.503919251312005e-17 0.9990740371631269 0.012023517512927821 2.313350247967729 0.1381003974019392 1.2833553603810235 0.08263199444647876 2.5333393284579462e-11 10.59630663468369 -1.7771262564496006 AEDGENYDIKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEDGENYDIKK 11 1 E5RJD8;O75347;E5RIW3;E5RHG6;O75347-2;E5RIX8;A0A494C144 E5RJD8 TBCA Tubulin-specific chaperone A 1 10797600.0 6738500.0 2743100.0 1316000.0 True False 9229905.551115355 2621900.771781345 1005187.9038707651 1.0 0.2840658289796379 0.10890554603229897 23.137884454287892 -13.99999953587622 0.2008194278977282 5.002792677364955 8.101339687804021e-11 0.9994714640694353 0.00886194530375081 12.718591617028274 0.1440316610156508 20.002204873605756 0.11023493336091197 1.0000010686850668e-14 13.99999953587622 -5.002792677283941 AEDGSVIDYELIDQDAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEDGSVIDYELIDQDAR 17 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33;H0YNA0 P07355 ANXA2 Annexin A2;Annexin 0 15372600.0 1766000.0 6589900.0 7016700.0 False True 2315243.1019683294 5606712.607229011 6290679.19293909 1.0 2.421651792186489 2.717070698792278 21.142732254641427 -10.286508627503254 0.34739436686995984 1.1040276238168691e-22 2.7762976740060825 0.999016812643102 0.023503383151099122 1.718693748401411 0.16167928109887048 1.692110501770286 0.08827456470919101 5.170009873523073e-11 10.286508627503254 2.7762976740060825 AEDGSVIDYELIDQDAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEDGSVIDYELIDQDAR 17 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33;H0YNA0 P07355 ANXA2 Annexin A2;Annexin 0 17504300.0 5347100.0 1466200.0 10691000.0 False True 5177359.237354559 2051661.3061319918 7890706.376874847 1.0 0.39627563243618297 1.5240793646196182 22.303784994142507 -6.761288402148601 1.6075908037768187 0.6498874178808626 1.5284690416270572 0.6962252130650793 0.2539770326954767 0.2807539694614704 1.4302991419179076 0.12463446809099332 0.29913998976495315 1.73265301189715e-07 6.761288402148601 0.8785816237461946 AEDGSVIDYELIDQDAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEDGSVIDYELIDQDAR 17 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33;H0YNA0 P07355 ANXA2 Annexin A2;Annexin 0 17036600.0 1766000.0 7704400.0 7566200.0 False True 2418937.9243555283 7363994.132956211 5779219.39078037 1.0 3.044308850926045 2.389155725159881 21.205942316164318 -10.092006396721663 5.307655755777688 0.9999739753378286 2.71673228804454 0.9015263220132305 0.2674651435916133 8.23694825997098e-05 1.4090846583968381e-05 0.25897590938713644 0.0863240039009777 8.090839820959273e-11 10.092006396721663 1.7167583127067116 AEDK(ub)EWMPVTK ddPTM_RPMI8226_Bortezomib_1h_R1 2 AEDKEWMPVTK 11 1 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 2073518200.0 665778200.0 985842700.0 421897300.0 True False 872841667.6052603 838758811.9447464 378243414.52066994 1.0 0.9609518462219797 0.43334711043117763 29.701144733597957 -6.92175386775441 0.8116151601708655 1.010921887398262 0.34473714897153157 0.9946543239697666 0.018893507322196905 0.09715090286716095 0.10034809256968431 0.016431697404327157 0.05007699810170652 1.19741896479173e-07 6.92175386775441 -0.6661847384267303 down AEDK(ub)EWMPVTK ddPTM_RPMI8226_Bortezomib_2h_R1 2 AEDKEWMPVTK 11 1 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 2233076630.0 878647030.0 566789200.0 787640400.0 True False 850754860.9797186 793111083.3266307 581333750.5344918 1.0 0.932243963217905 0.6833152265095908 29.664168248476134 -6.946830803221098 0.5926223882493631 1.0028556580505494 0.6001213565678211 0.9989284763817724 0.0044569389916831485 0.08478398022609511 0.04142643188050495 0.004608273866583294 0.020870576926750043 1.1302361575931435e-07 6.946830803221098 -0.4027343014827284 AEDK(ub)EWMPVTK ddPTM_RPMI8226_Bortezomib_8h_R1 2 AEDKEWMPVTK 11 1 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 4709422000.0 3173850100.0 1222980900.0 312591000.0 True False 4814962641.222767 1004730403.2016147 250807251.83649775 1.0 0.20866836942819186 0.05208913765794139 32.164877458382776 -12.056465145132442 0.26910554361986433 2.9240844084874658 7.760901880173529e-15 0.9993603372639142 0.010493395747160083 5.535080163480771 0.15900235108438251 5.979945988039782 0.06518893754740152 8.780815558441267e-13 12.056465145132442 -2.924084408487458 AEDK(ub)EWMPVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AEDKEWMPVTK 11 1 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 1801845000.0 665778200.0 615207500.0 520859300.0 True False 911934392.5193423 588025598.4308529 397843060.77400756 1.0 0.6448112970126639 0.43626281017312246 29.76435479512085 -9.51313106307844 0.1253739658193755 1.6506070072688195 2.3027035160820939e-10 0.9998845075574195 0.002501035759280428 0.9694876309616854 0.04964223390606544 0.42929505038924604 0.21276703267771516 3.068095946734243e-10 9.51313106307844 -1.6506070070385492 AEDK(ub)EWMPVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AEDKEWMPVTK 11 1 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 1977776930.0 878647030.0 773742900.0 325387000.0 True False 730633936.1083058 769574593.4217596 393423917.28049755 1.0 1.0532970826962538 0.5384692632483721 29.44457352391041 -6.881356794620478 1.072246383239698 1.033660607670761 0.5010273474644638 0.9747616643354516 0.03672281633215754 0.12643304702554156 0.2651044575766108 0.02635017939286064 0.06394456280901357 1.3141447529953233e-07 6.881356794620478 -0.5326332602062973 AEDK(ub)EWMPVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AEDKEWMPVTK 11 1 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 4533986500.0 3173850100.0 1190324100.0 169812300.0 True False 4108611520.38869 1124081517.456021 138908203.82133698 1.0 0.2735915799967573 0.03380903819502403 31.936003780475225 -9.339933977643732 0.3815490371360425 1.2320598904165674 3.71149564873801e-17 0.9978612723029944 0.018997262122119597 0.7529820410056725 0.1595829293240477 0.30993281623683494 0.0633576153378232 4.5715768240039046e-10 9.339933977643732 -1.2320598904165674 AEDKEWMPVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEDKEWMPVTK 11 1 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 0 9348800.0 2661000.0 862400.0 5825400.0 False True 2576528.0115577574 1206760.8173565888 4299552.981746023 1.0 0.46836704741548163 1.6687390792800005 21.29699684662621 -6.786331141765565 1.511170253031842 0.7014466575488536 1.6802102865445339 0.789154206441204 0.22550957003515193 0.24086418466608153 1.0866969559616582 0.11749175501830565 0.2758053379400374 1.6355689538250192e-07 6.786331141765565 0.9787636289956803 AEDKEWMPVTK(ub)LGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEDKEWMPVTKLGR 14 2 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 91044000.0 15680000.0 65170000.0 10194000.0 True False 20556631.845336005 55446890.03067041 9139222.667752804 1.0 2.6972750423241387 0.44458755386166815 24.29310056599553 -6.705124773109239 1.8124983902914362 2.0485874237478927 0.45057379262121217 0.44200261807425656 0.7157896601168561 0.38493746988962974 2.4618818110100906 0.3146378758391735 0.8041146952986706 1.9718561390751875e-07 6.705124773109239 -1.5980136311266806 AEDKEWMPVTK(ub)LGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEDKEWMPVTKLGR 14 2 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 140620000.0 39227000.0 70636000.0 30757000.0 True False 37981760.356774226 98841323.1618739 22700819.0097783 1.0 2.6023365487388497 0.5976768532196138 25.178803436448135 -6.693810087759729 1.8526322317728747 2.000935939065256 0.6042208166278491 0.3884286029664713 0.6771581106077195 0.4085294602245318 2.7213691683617443 0.292070943446145 0.7570092105862946 2.023904016351728e-07 6.693810087759729 -1.3967151224374068 AEDKEWMPVTK(ub)LGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEDKEWMPVTKLGR 14 2 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 398259000.0 103210000.0 143790000.0 151259000.0 True False 156577115.66170132 118129551.0636021 121362592.35082513 1.0 0.754449656096817 0.7750978924215192 27.222298131792332 -10.698650661436302 6.707047400600511 1.0022403787376934 0.7647737742591681 0.9942541626395247 0.008429607180653487 0.00028474775697034157 1.279376475369462e-05 0.008229837954336674 0.0027206440188117815 2.001471169220406e-11 10.698650661436302 -0.2374666044785253 AEDKEWMPVTK(ub)LGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEDKEWMPVTKLGR 14 2 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 68589000.0 15680000.0 22177000.0 30732000.0 True False 21477319.73606719 21197146.810468026 23473734.54540753 1.0 0.9869549399533003 1.092954560153413 24.356310627518422 -6.876099233645416 1.1013759648589307 0.9922664403651904 1.0999251330246684 0.9703979947280676 0.00812007491991942 0.1311389182384195 0.2936740028653901 0.005698048370378125 0.0136521434403508 1.3301504519710277e-07 6.876099233645416 0.10765869265947803 AEDKEWMPVTK(ub)LGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEDKEWMPVTKLGR 14 2 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 103372500.0 39227000.0 49800000.0 14345500.0 True False 32618988.550750017 49531717.515473984 17345077.7239022 1.0 1.5184933597315693 0.5317478712411939 24.95920871188241 -6.763919788012988 1.5976147671164516 1.2996963150747811 0.5274143086052162 0.7068042244876764 0.21822070026619333 0.2763795735867178 1.3911174167369624 0.10772648237578485 0.25790221514188566 1.722186624744496e-07 6.763919788012988 -0.7722820064695649 AEDKEWMPVTK(ub)LGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AEDKEWMPVTKLGR 14 2 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 476838000.0 124071000.0 152803000.0 199964000.0 True False 160612355.30504274 144299378.72536796 163572603.80390495 1.0 0.8984326171626561 1.0184310135620636 27.259007637332044 -6.6823943993435675 1.8931369861934264 0.9358738016774832 1.017984785849067 0.335062994411472 0.04302475159048529 0.43332036903266996 3.0045447271847605 0.018221259004810315 0.047914710397013775 2.0778088927300634e-07 6.6823943993435675 0.08211098417158369 AEDNADTLALVFEAPNQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEDNADTLALVFEAPNQEK 19 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 55139000.0 10350000.0 22078000.0 22711000.0 False True 13568950.229542572 18784048.45936998 20361083.57929507 1.0 1.3843405821087764 1.5005643940652489 23.69380577426701 -12.18648025961676 0.19526216122568207 4.3795504236558625e-10 1.587347963006375 0.9994227620927469 0.0051391818593625755 5.750951926635399 0.125367558127272 2.373564259946944 0.07625090825724569 6.509081964920126e-13 12.18648025961676 1.58734796256842 AEDNADTLALVFEAPNQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEDNADTLALVFEAPNQEK 19 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 62296500.0 19376000.0 8952500.0 33968000.0 False True 18760919.485886183 12527279.936670747 25070761.781843122 1.0 0.6677327273908406 1.3363290536321435 24.16122720129832 -6.771579361235739 1.5683486636650676 0.8098030382370613 1.3403205980329185 0.7365685831172668 0.1400957032800858 0.2638929179188213 1.2812314489747487 0.07039932921573319 0.1673420626510678 1.6920790124357033e-07 6.771579361235739 0.5305175597958571 AEDNADTLALVFEAPNQEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEDNADTLALVFEAPNQEK 19 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 115993400.0 0.0 107420000.0 8573400.0 False True 0.0 88250061.7237092 6878863.732145286 0.0 AEDNADTLALVFEAPNQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEDNADTLALVFEAPNQEK 19 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 52810000.0 10350000.0 21550000.0 20910000.0 False True 14176674.698233118 20597849.743679784 15971488.654967846 1.0 1.4529394362309065 1.1266033110683158 23.7570158357899 -10.579943412315691 10.161542900834732 0.9999843817473855 1.289771373649611 0.5125000806288145 0.1332261652142289 4.714192845953456e-05 1.9487753103286703e-06 0.1290026154719684 0.04299855992948219 2.630610732773338e-11 10.579943412315691 0.28978699190222557 AEDNADTLALVFEAPNQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEDNADTLALVFEAPNQEK 19 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 36685900.0 19376000.0 8740800.0 8569100.0 False True 16112002.502341047 8693711.57548704 10360859.190958176 1.0 0.5395798302677682 0.6430522332312673 23.941632476732597 -10.013483672961492 6.028354721710019 1.0000004616546636 0.591316031749504 0.9541285942535337 0.04224243162015785 2.621168276369437e-07 4.286696169388812e-08 0.04090110486026833 0.013633686180663624 9.69429713739248e-11 10.013483672961492 -0.40868442990515963 AEDNADTLALVFEAPNQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEDNADTLALVFEAPNQEK 19 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 22353800.0 0.0 14437000.0 7916800.0 False True 0.0 13633568.258857042 6476023.633227755 0.0 AEDNADTLALVFEAPNQEK(ub)VSDYEMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 AEDNADTLALVFEAPNQEKVSDYEMK 26 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 43716800.0 12388800.0 10357200.0 20970800.0 True False 11995524.325286265 14492883.972084483 15477918.369485278 1.0 1.2081909534820288 1.290307780615993 23.515992883531755 -13.999999999371223 0.1285029640204634 0.010732956116309398 1.4075234413407 0.9996524435134616 0.0022778941459498853 11.939367642383056 0.11132669906937606 2.9873769486458435 0.10418967684185038 1.0000000014478127e-14 13.999999999371223 1.3967904852243906 AEDNADTLALVFEAPNQEK(ub)VSDYEMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEDNADTLALVFEAPNQEKVSDYEMK 26 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 129964000.0 10414000.0 15920000.0 103630000.0 True False 15798799.36538085 13078951.616472254 83147485.07735749 1.0 0.8278446554066338 5.26289898076398 23.913311588726135 -6.897870265893586 0.9746553894352892 0.8046773939258159 5.708776837985579 0.9854759663865466 0.2472176609793407 0.11298921166192337 0.18640259029970338 0.19097619077777683 0.4917736965872777 1.2651142107790795e-07 6.897870265893586 4.904099444059763 up AEDNADTLALVFEAPNQEK(ub)VSDYEMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AEDNADTLALVFEAPNQEKVSDYEMK 26 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 40901900.0 12388800.0 12548900.0 15964200.0 True False 10301836.116897332 12481296.584938386 19302240.40987904 1.0 1.211560390139215 1.8736699158142323 23.29639815896603 -6.950495859334281 0.5533740640691147 0.9910210713105588 2.125494676350799 0.9992396173564274 0.010261987908729673 0.08328726046058015 0.03514318438778989 0.011090448830445155 0.05496346364161158 1.1207381114664159e-07 6.950495859334281 1.1344736050402404 AEDNADTLALVFEAPNQEK(ub)VSDYEMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEDNADTLALVFEAPNQEKVSDYEMK 26 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 106061000.0 10414000.0 0.0 95647000.0 True False 13481128.290629685 0.0 78240227.42109635 1.0 0.0 5.803685398905277 23.684437910818584 -6.862497168290601 1.173141026130723 0.45346906058940617 6.098313807515019 0.9565991824755029 0.5277574420948485 0.14424645998010224 0.3758318416634726 0.3505182104943028 0.8206042365825372 1.3724699098278552e-07 6.862497168290601 5.644844746925613 up AEEETDEEK(ub)PK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEEETDEEKPK 11 1 Q9UHP3;Q9UHP3-1;Q9UHP3-3 Q9UHP3 USP25 Ubiquitin carboxyl-terminal hydrolase 25 1 7543830.0 3333700.0 1423200.0 2786930.0 True False 4370512.983596721 1210864.10759015 2498565.217720263 1.0 0.27705308556106095 0.5716869454679128 22.059371193548085 -10.44786555325486 6.089811215260588 1.000249889991384 0.4243700155156383 0.8357782032431887 0.12028376961974185 0.00040826720869160997 3.701590127512634e-05 0.11651337585478379 0.03882141971302575 3.565614988935567e-11 10.44786555325486 -0.5758798744757458 AEEETDEEK(ub)PK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEEETDEEKPK 11 1 Q9UHP3;Q9UHP3-1;Q9UHP3-3 Q9UHP3 USP25 Ubiquitin carboxyl-terminal hydrolase 25 1 5837970.0 2452440.0 2229230.0 1156300.0 True False 2374588.634597788 3119373.164280872 853430.3417435583 1.0 1.313647812017443 0.359401341903632 21.17924617698732 -6.818137365228056 1.379842526915195 1.1693755641900223 0.33937563227063633 0.8800776870045565 0.13752134637422136 0.19590067781743697 0.7333888247102196 0.07832833857248463 0.18063631762309032 1.5200666640111065e-07 6.818137365228056 -0.829999931919386 down AEEETDEEK(ub)PK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEEETDEEKPK 11 1 Q9UHP3;Q9UHP3-1;Q9UHP3-3 Q9UHP3 USP25 Ubiquitin carboxyl-terminal hydrolase 25 1 8562510.0 3333700.0 2829230.0 2399580.0 True False 4566258.979855048 2704225.2635875233 1832848.6249013753 1.0 0.5922189861586359 0.40138954732689247 22.122581255070976 -13.999999999999508 0.10138118253535218 3.005945000945878 0.003507745852593662 0.9997867804089958 0.003645751003484433 12.070049349603305 0.09509964312211856 5.048159714151843 0.3545875294776116 1.000000000001133e-14 13.999999999999508 -3.0024372550932843 AEEETDEEK(ub)PK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEEETDEEKPK 11 1 Q9UHP3;Q9UHP3-1;Q9UHP3-3 Q9UHP3 USP25 Ubiquitin carboxyl-terminal hydrolase 25 1 5245570.0 2452440.0 2153540.0 639590.0 True False 2039312.5215132795 2141938.4525757777 773325.3118699668 1.0 1.050323788031441 0.37920882832422265 20.959651452421596 -6.888831447857667 1.0292903327625118 1.0370765635196069 0.32279528497755505 0.9801390326810132 0.04301115659878431 0.12009557963884177 0.22743668532102287 0.03188791384214786 0.07916846326789927 1.291720500367612e-07 6.888831447857667 -0.7142812785420518 down AEEILEK(ub)GLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEEILEKGLK 10 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 27067400.0 5877500.0 12642900.0 8547000.0 True False 7705459.417790957 10756628.601638218 7662638.428613229 1.0 1.3959749858395838 0.9944427727334648 22.87744954553334 -9.243820894411806 11.855822758626799 0.9999987271878112 1.1952088792865243 0.23962197549613362 0.16392483956839193 0.0 0.0 0.1587195434187818 0.052906514472927255 5.703994598593771e-10 9.243820894411806 0.19521015209871306 AEEILEK(ub)GLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEEILEKGLK 10 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 37378600.0 11773000.0 9211700.0 16393900.0 True False 11399272.559214385 12889979.848380903 12099845.783542084 1.0 1.1307721419435255 1.0614577132609575 23.442438426434958 -10.475158906741019 6.086163778005632 0.9999385499851536 1.0961149276022415 0.7193955109172523 0.028297497014137734 2.360985444441562e-05 2.0359748106335683e-06 0.02741643105511367 0.009132977889592457 3.348428989652096e-11 10.475158906741019 0.09617637761708786 AEEILEK(ub)GLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEEILEKGLK 10 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 182019300.0 14635700.0 15998100.0 151385500.0 True False 22203426.912992533 13143114.061274176 121464089.5703781 1.0 0.5919407897158148 5.470510928171286 24.404279025869283 -6.8865932513904795 1.042364374301617 0.7160611520719152 5.863083122024702 0.9786251828655996 0.32308841011359085 0.12194913098994063 0.23836282814294185 0.23717057554079327 0.5844434159620148 1.2983947435355693e-07 6.8865932513904795 5.147021969952787 up AEEILEK(ub)GLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEEILEKGLK 10 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 22901600.0 5877500.0 7239800.0 9784300.0 True False 8050570.583465226 6919921.697182958 7473449.853983828 1.0 0.859556676814378 0.9283130650805391 22.940659607056233 -10.239324876002552 4.801331838307737 1.0000236220969856 0.8939348709472364 0.7603591213566736 0.02806967796889702 7.099299991767003e-06 1.1247503353658936e-06 0.027184399955566246 0.009059449608802922 5.763351718977117e-11 10.239324876002552 -0.10608875114974914 AEEILEK(ub)GLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEEILEKGLK 10 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 36873400.0 11773000.0 14230700.0 10869700.0 True False 9789771.132331803 14154036.394527208 13142504.014185641 1.0 1.445798497554446 1.3424730605581847 23.222843701869234 -10.108723415349651 4.883842007506004 0.9999860472984038 1.394135779049504 0.9509819183170692 0.04218243307268048 8.033421004113638e-06 1.466119316574321e-06 0.0408447760581564 0.013614321724151206 7.785322089742482e-11 10.108723415349651 0.39414973175110013 AEEILEK(ub)GLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEEILEKGLK 10 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 202358200.0 14635700.0 17132500.0 170590000.0 True False 18946202.162777863 16179061.31432213 139544370.40121317 1.0 0.8539474653188215 7.365295123650966 24.175405347961732 -6.9017728628681025 0.9500256372458442 0.7422932986966118 8.073838165656664 0.9874269434499533 0.3403851635297633 0.11011095824908515 0.1701655649493038 0.26780633409094673 0.7031665061574399 1.253796742418257e-07 6.9017728628681025 7.331544866960052 up AEEQMLK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEEQMLKER 9 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 10009100.0 4537200.0 3971000.0 1500900.0 True False 5948313.138307306 3378542.278836766 1345601.2656494214 1.0 0.567983258493716 0.22621560673793564 22.50404916681399 -7.918179602022859 0.296616903801111 1.120818076746226 3.657775343868162e-12 0.9993069903487306 0.0083348213489883 0.10784197743842043 0.05273494285724321 0.0518760359368796 0.08775005596063014 1.2073144482425128e-08 7.918179602022859 -1.1208180767425682 down AEEQMLK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEEQMLKER 9 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 4313200.0 2375700.0 0.0 1937500.0 True False 2300284.7038924317 0.0 1430010.6262459105 1.0 0.0 0.6216667979516253 21.133381002439126 -10.178942334825619 7.001568244367188 1.0000012292294225 0.3108333989758127 0.6210105374032315 0.2537944075018949 4.87013733365877e-06 5.705829307301943e-07 0.24573581771540023 0.08191179280128477 6.623044379654275e-11 10.178942334825619 -0.6891678302536097 AEEQMLK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEEQMLKER 9 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 13367800.0 4556300.0 6697400.0 2114100.0 True False 6912240.2101483345 5502196.642974964 1696247.2083570515 1.0 0.7960077305902667 0.24539760725714863 22.720721923395022 -6.953798896758411 0.5154533440596875 1.0096960233648036 0.007327449224169825 0.9994666748333503 0.007360332375638432 0.08199520272425467 0.029919583791421036 0.008399989174129721 0.04546183774038854 1.1122466420110369e-07 6.953798896758411 -1.0023685741406339 down AEEQMLK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEEQMLKER 9 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 8391500.0 4537200.0 2354500.0 1499800.0 True False 6214725.453219649 2250470.4047096963 1145578.1293505856 1.0 0.36211903834686693 0.18433286200231072 22.56725922833688 -13.999999999998066 0.1792347295216223 4.301966059506266 0.04198667980595257 0.9994990808884453 0.007838088558362237 12.194933422848205 0.13420135899538677 14.020754792067605 0.13360994327523773 1.0000000000044542e-14 13.999999999998066 -4.259979379700313 AEEQMLK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEEQMLKER 9 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 10424500.0 2375700.0 5785400.0 2263400.0 True False 1975499.8113548507 5754232.901888016 2736666.475220818 1.0 2.912798507402341 1.3853033341187408 20.913786277873402 -6.590025811119592 2.2286723747949195 2.294582452512829 1.389725008743247 0.0 0.8288699630515287 0.6694528212420736 6.268754689106766 0.3104648257117871 0.9239161363733764 2.5702430227771097e-07 6.590025811119592 -0.9048574437695822 AEEYEFLTPVEEAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEEYEFLTPVEEAPK 15 0 P52565;J3KTF8;J3QQX2;J3KRE2 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 0 28861900.0 7779600.0 2898300.0 18184000.0 False True 7532640.856337749 4055606.3044348327 13421064.891693225 1.0 0.5384043102257505 1.7817210653818871 22.84472431501845 -6.806183390726526 1.4305702776960736 0.7472772988975634 1.8016141990373649 0.8496146260706947 0.19900099882343142 0.2120510642642496 0.8560059128049281 0.10940388051093028 0.25353291864461075 1.5624877073285648e-07 6.806183390726526 1.0543369001398015 AEEYEFLTPVEEAPK(ub)GMLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEEYEFLTPVEEAPKGMLAR 20 1 P52565;J3KRE2 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 1 14457600.0 5430700.0 3519800.0 5507100.0 True False 5258305.401114892 4925274.495514513 4064625.300541339 1.0 0.9366657354040775 0.7729914849904946 22.326166505095024 -6.954747117626603 0.5040427250099417 1.003166114618926 0.6993829773244489 0.9995230755851077 0.00208876591426566 0.08163370136993181 0.0284930644376734 0.002431353868218138 0.01350384991978084 1.109820857176047e-07 6.954747117626603 -0.30378313729447703 AEFFADVVPAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEFFADVVPAVR 12 0 A0A0C4DGY8;D6RA00;Q9UHY7 A0A0C4DGY8 ENOPH1 Enolase-phosphatase E1 0 6039700.0 1661100.0 2116100.0 2262500.0 False True 2177718.186115282 1800386.1284931938 2028398.2034324815 1.0 0.82673053840121 0.9314328255901813 21.05438583935715 -10.255595692175598 4.99061182763506 1.0000233055008505 0.8790816820035425 0.6400706153362491 0.04274452975282728 1.1086110819216266e-05 1.6535834654077877e-06 0.04139518676113214 0.013795737656141529 5.551422839376337e-11 10.255595692175598 -0.12094162349730797 AEGAENK(ub)TSDK(ub)ANNNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEGAENKTSDKANNNR 16 2 O60239;O60239-2 O60239 SH3BP5 SH3 domain-binding protein 5 2 2215320.0 319410.0 364710.0 1531200.0 True False 418749.6031708399 310296.6896284456 1372766.112307544 1.0 0.741007722225475 3.278250539016005 18.67572829772149 -6.881741412641012 1.070071384059363 0.8354797450799057 3.4641543709810496 0.9750618345091522 0.18001679843243182 0.12609726576730862 0.2630768607699783 0.12938374628956034 0.3143057300299737 1.31298144094271e-07 6.881741412641012 2.628674625901144 up AEGAQNQGQK(ub)GEGAQNQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEGAQNQGQKGEGAQNQGK 19 1 Q9P2E9 Q9P2E9 RRBP1 Ribosome-binding protein 1 1 2141870.0 596120.0 974070.0 571680.0 True False 577196.4968995905 1363021.2307079441 421939.8579676183 1.0 2.36145097558528 0.7310159715695906 19.138703018339164 -6.685150331207681 1.8834720102831526 1.857415300689294 0.7369441368556084 0.3477738446760179 0.5763821879416359 0.4272548522132032 2.934615473096639 0.24515410265218557 0.6423700322592677 2.0646653473707004e-07 6.685150331207681 -1.1204711638336855 AEGDSAGTAGTPGGTPAGDK(ub)VASWELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEGDSAGTAGTPGGTPAGDKVASWELR 27 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 23646500.0 4748300.0 5412200.0 13486000.0 True False 7203518.247228518 4446350.624288393 10820486.188876214 1.0 0.6172470828402611 1.50211130415881 22.780270270061077 -6.789154455209661 1.4997808290025016 0.7858449938263316 1.51129528871936 0.7985550982066828 0.16262682079693896 0.23661248447707942 1.0514514381470959 0.08535555783186627 0.19995593755763208 1.6249707382006715e-07 6.789154455209661 0.7254502948930285 AEGDSAGTAGTPGGTPAGDK(ub)VASWELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEGDSAGTAGTPGGTPAGDKVASWELR 27 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 6739100.0 1933000.0 2342400.0 2463700.0 True False 1607375.146419553 2329781.026270002 2978848.279138258 1.0 1.4494320330008938 1.85323773717273 20.616275249249504 -6.972394966290549 0.1925717158306072 0.7353516308057458 2.5783792016773726 0.999995534795588 0.0007363912754756217 0.07553295206624797 0.0061621710240356035 0.013948157365290285 0.04371035347780064 1.0656265532787603e-07 6.972394966290549 1.8430275708716266 AEGDSAGTAGTPGGTPAGDK(ub)VASWELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEGDSAGTAGTPGGTPAGDKVASWELR 27 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 40367000.0 4748300.0 6643700.0 28975000.0 True False 6146767.9529860625 6273972.254718334 23701847.308606274 1.0 1.0206945020058025 3.8559853714816192 22.551396592153527 -6.908498633537693 0.9058803160257236 0.9079908315231745 4.210893010135755 0.9903429751186438 0.13182679726710314 0.10541973642488792 0.14420776385126272 0.10713346576494086 0.2927556911070335 1.2345291994819905e-07 6.908498633537693 3.3029021786125803 up AEGGGGGGRPGAPAAGDGK(ub)TEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEGGGGGGRPGAPAAGDGKTEQK 23 2 Q00839 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 6610800.0 1850500.0 2809300.0 1951000.0 True False 2426023.420267494 2390163.390565632 1749129.2353134896 1.0 0.9852185970661783 0.7209861292767858 21.21016204729318 -6.918427747408116 0.8363199330832413 1.0061670291004043 0.6798820438959149 0.9937326074129735 0.010148122382386937 0.09910555159355455 0.11047802968759433 0.008671618638392541 0.025597158635847068 1.2066248149440098e-07 6.918427747408116 -0.32628498520448945 AEGGGGGGRPGAPAAGDGK(ub)TEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEGGGGGGRPGAPAAGDGKTEQK 23 2 Q00839 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 6766400.0 1850500.0 3481700.0 1434200.0 True False 2534679.8578821663 3327866.9815577683 1095471.4982761766 1.0 1.312933848907587 0.43219323926434244 21.273372108816073 -6.810656326434258 1.4118396816385324 1.170412291828655 0.41656200679352207 0.8615218668176475 0.13565677712966986 0.20590461147940034 0.8088045183434184 0.07555085512858851 0.1747077650359053 1.5464777414819074e-07 6.810656326434258 -0.753850285035133 down AEGPEVDVNLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEGPEVDVNLPK 12 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 45902600.0 2024600.0 27534000.0 16344000.0 False True 2654270.206254292 23426034.526691366 14652879.66271846 1.0 8.82579116153747 5.5204928376137765 21.339883814704546 -9.953086950018545 7.665116082375951 0.9999999416829346 7.173141999575624 0.8230346713995875 1.3493823902149222 1.3379475598219055e-06 1.8287508874086436e-07 1.306533881240592 0.435511293747329 1.1140714632187765e-10 9.953086950018545 6.17314205789269 AEGPEVDVNLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEGPEVDVNLPK 12 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 37272500.0 10584000.0 7757500.0 18931000.0 False True 10248016.713388683 10855110.204828085 13972403.182173593 1.0 1.0592400957588461 1.3634250970647936 23.288841397882667 -6.939213706853634 0.6668396385936975 0.9965349288316779 1.4435905623427316 0.9980590751455071 0.007013915869277555 0.08812717599006278 0.05625722501916484 0.006787513603837467 0.026272593080679328 1.1502342444478177e-07 6.939213706853634 0.4470556335110537 AEGPEVDVNLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEGPEVDVNLPK 12 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 55822600.0 2024600.0 31959000.0 21839000.0 False True 2773149.3327577584 30546945.705719814 16681077.988323428 1.0 11.015254514023017 6.015210861989509 21.403093876227437 -9.42765059320654 11.895763772736643 0.9999553589467194 8.515232688006263 0.7507568225578961 2.041259273350082 0.0 0.0 1.976440792670559 0.6588135975568528 3.7355057288900447e-10 9.42765059320654 7.515277329059543 AEGSDVANAVLDGADCIMLSGETAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEGSDVANAVLDGADCIMLSGETAK 25 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 18003000.0 11287000.0 1473100.0 5242900.0 False True 10928700.363191446 2061316.5121150154 3869627.206371444 1.0 0.18861497191904536 0.35407935781683547 23.38161851068703 -10.212861248764403 7.932054276086832 1.000000415808453 0.27134716525584507 0.9627651694115422 0.06755055267542574 4.967163429768922e-07 4.939415097452856e-08 0.06540557841645842 0.021801847128252564 6.125460606796944e-11 10.212861248764403 -0.728653250552608 AEGSDVANAVLDGADCIMLSGETAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEGSDVANAVLDGADCIMLSGETAK 25 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 5939800.0 2444000.0 1318300.0 2177500.0 False True 3347612.846616592 1260053.1469648748 1663219.3470202056 1.0 0.37640348651380084 0.4968374251225644 21.67470125833458 -9.486694672522306 12.30737982134061 1.0000004780128784 0.43662044389172255 0.9668623616097042 0.049166949551633074 0.0 0.0 0.047605694198975104 0.015868564732991697 3.2606585859474753e-10 9.486694672522306 -0.5633800341211559 AEGSDVANAVLDGADCIMLSGETAK(ub)GDYPLEAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEGSDVANAVLDGADCIMLSGETAKGDYPLEAVR 34 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 289324500.0 8778500.0 28186000.0 252360000.0 True False 13317626.29431492 23155988.08177684 202480935.3866826 1.0 1.738747399126356 15.203980868055925 23.666833626606216 -6.9182214146338525 0.8378090788836245 0.683426851346334 17.28897986839011 0.9936724824256916 0.5193272837030397 0.0992297362951173 0.11111940140079138 0.4432893066748512 1.3061076220237195 1.2071982171102476e-07 6.9182214146338525 16.60555301704378 up AEGSDVANAVLDGADCIMLSGETAK(ub)GDYPLEAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEGSDVANAVLDGADCIMLSGETAKGDYPLEAVR 34 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 176478500.0 8778500.0 11110000.0 156590000.0 True False 11363941.30010491 10491718.733525109 128092226.74908213 1.0 0.9232464737765101 11.271813481463479 23.437959948698666 -6.905226484505645 0.927609781034106 0.629238918119591 12.481233964023488 0.9889925894025879 0.5099317236535957 0.10766049829736336 0.1565078542374275 0.40787511524503445 1.0919734322434609 1.2438657667933714e-07 6.905226484505645 11.851995045903898 up AEGTFPGK(ub)I ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEGTFPGKI 9 1 P14854 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 1 11072200.0 3859700.0 3091300.0 4121200.0 True False 3209511.563701785 3074646.553324996 4982923.865724154 1.0 0.9579795842139797 1.5525489679111644 21.613922328278655 -6.88993305493133 1.0227527644726777 0.9680018612325793 1.6036253766400037 0.9808563089849786 0.03748497201409558 0.11919855056972238 0.22215242358823428 0.02792803958968262 0.06961003197452145 1.2884481464383933e-07 6.88993305493133 0.6356235154074245 AEGTFPGK(ub)I ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEGTFPGKI 9 1 P14854 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 1 39886000.0 0.0 15707000.0 24179000.0 True False 0.0 14832891.642437326 19778670.097490627 0.0 AEHASSLLELASTTK(ub)CSSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEHASSLLELASTTKCSSVK 20 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 47008800.0 4997800.0 26217000.0 15794000.0 True False 7582027.988121783 21538371.515644073 12672308.977243884 1.0 2.8407137970720613 1.6713614084644208 22.854152351373482 -10.196664842139608 5.613616003233199 0.9999611504558144 2.2560376027683082 0.6060422233421002 0.4773861135991431 0.0002321206265843383 3.32184934394413e-05 0.4622412973454985 0.1540757056399789 6.358214247093155e-11 10.196664842139608 1.2560764523124939 AEHASSLLELASTTK(ub)CSSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEHASSLLELASTTKCSSVK 20 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 22434900.0 4997800.0 7522000.0 9915100.0 True False 6469750.621366326 7103394.087630582 8110653.537517255 1.0 1.0979393957120467 1.2536269189003753 22.62527867346593 -6.964274780135835 0.3702882732622291 0.9880665757624428 1.36892143977335 0.9998974031165706 0.0010577931756011727 0.07820793694438075 0.01573298544750901 0.002051183103295757 0.013220398228299466 1.0857384544894376e-07 6.964274780135835 0.3808548640109072 AEIIADK(ub)QSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEIIADKQSGK 11 1 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 1 5036900.0 1848900.0 1624700.0 1563300.0 True False 2423925.804773068 1382301.0930309976 1401544.7122324877 1.0 0.5702736817723721 0.5782127115741905 21.208914108595362 -10.162956941633709 6.505793867545432 1.0000015259167172 0.5742431966732814 0.9997392879692475 0.0032410953445355085 7.173427273620037e-08 9.229228431882693e-09 0.0031381883179490513 0.0010460590244044867 6.87136563171218e-11 10.162956941633709 -0.4257583292434358 AEIIADK(ub)QSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEIIADKQSGK 11 1 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 1 19935700.0 2744800.0 3994900.0 13196000.0 True False 4164062.2717589103 3281978.8827038333 10587804.815987725 1.0 0.7881675797604047 2.5426624591556384 21.989560213006175 -6.876724126119668 1.0978611213162897 0.8736103279332094 2.6594696698207017 0.9709476497767643 0.13328045964778856 0.1305735841071517 0.2901324836767378 0.09377358030621184 0.225005363710215 1.3282379171954928e-07 6.876724126119668 1.7858593418874924 up AEIIADK(ub)QSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEIIADKQSGK 11 1 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 1 4444100.0 1848900.0 1309900.0 1285300.0 True False 2532488.294643788 1252024.2867399605 981738.6115844169 1.0 0.4943850241629908 0.38765770947916867 21.272124170118254 -13.999999999999998 0.21862673616564773 4.032858573425899 0.32981237326383855 0.9994965543295463 0.005992699018675831 12.96262018546962 0.14813572052815577 16.96071741668992 0.05960505344870924 1.0000000000000041e-14 13.999999999999998 -3.7030462001620603 AEIIADK(ub)QSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEIIADKQSGK 11 1 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 1 6976300.0 2037800.0 3470500.0 1468000.0 True False 1694520.9898467488 3451803.7276596846 1774952.0127348946 1.0 2.037038046942023 1.0474653447021745 20.692446076762938 -6.635214470168909 2.06156631842495 1.680622790977593 1.0515274787127702 0.13645972556427177 0.4442551178413559 0.5456415362180926 4.425926869438733 0.17584153057414706 0.4920207705116235 2.31625052002499e-07 6.635214470168909 -0.6290953122648228 AEIIADK(ub)QSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEIIADKQSGK 11 1 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 1 24148600.0 2744800.0 2338800.0 19065000.0 True False 3553197.7080968223 2208643.724029571 15595365.623419452 1.0 0.6215932535914455 4.389107194311657 21.760686535098625 -6.8821715830828 1.067581023399926 0.7579758914196135 4.667517552474408 0.9753966524097977 0.2656944985423584 0.1257253364010744 0.2607920341328391 0.19131974100772395 0.4653345438157958 1.3116815713815082e-07 6.8821715830828 3.909541661054794 up AEIK(ub)EMGEMHR ddPTM_RPMI8226_Bortezomib_1h_R1 3 AEIKEMGEMHR 11 1 P16422;B5MCA4 P16422 EPCAM Epithelial cell adhesion molecule 1 27181460.0 8880730.0 12771060.0 5529670.0 True False 11642723.031111652 10865667.629201982 4957512.792740107 1.0 0.933258276450172 0.42580354952124644 23.472925183285973 -6.931055282088648 0.7380787734148502 1.0074226058073097 0.3187697785224193 0.9967416066906559 0.0146358816445684 0.09209358834967112 0.07502291311009773 0.013418673125478234 0.045652373963241295 1.172046164288052e-07 6.931055282088648 -0.6886528272848904 down AEIK(ub)EMGEMHR ddPTM_RPMI8226_Bortezomib_2h_R1 2 AEIKEMGEMHR 11 1 P16422;B5MCA4 P16422 EPCAM Epithelial cell adhesion molecule 1 20217230.0 7297400.0 7061260.0 5858570.0 True False 7065748.031394802 9880857.941984443 4324034.763667348 1.0 1.398416402351377 0.6119712653854384 22.752410872141947 -6.768964209438046 1.5782862563210331 1.2288204969936458 0.6077053284434178 0.7266435109203262 0.16786885469280918 0.2681007360441369 1.3178190714438451 0.0838425087230767 0.19978096281630017 1.7022987904442076e-07 6.768964209438046 -0.621115168550228 AEIK(ub)EMGEMHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEIKEMGEMHR 11 1 P16422;B5MCA4 P16422 EPCAM Epithelial cell adhesion molecule 1 30430600.0 12898000.0 10242000.0 7290600.0 True False 19567208.970105838 8414235.078888763 5849609.714416502 1.0 0.43001713181188816 0.298949621448483 24.22193465154328 -13.999999999999998 0.20651779816722346 4.2501502980804355 0.21909370218392998 0.9994883541790603 0.006883734841642797 12.667403838619443 0.14406204632578706 16.6781759940377 0.07957614597951823 1.0000000000000041e-14 13.999999999999998 -4.031056595896506 AEIK(ub)EMGEMHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEIKEMGEMHR 11 1 P16422;B5MCA4 P16422 EPCAM Epithelial cell adhesion molecule 1 15857400.0 6892300.0 4698000.0 4267100.0 True False 9440569.56740407 4490426.825791528 3259298.863683084 1.0 0.47565210909475747 0.34524387966342934 23.170442472055473 -13.99999999999993 0.19541725310090624 3.8654338427495665 0.2566212848148556 0.9994873307718047 0.0064070803662596865 12.443980807372144 0.1401838782506145 13.604028406230471 0.08596665081173359 1.0000000000001595e-14 13.99999999999993 -3.608812557934711 AEIK(ub)EMGEMHR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AEIKEMGEMHR 11 1 P16422;B5MCA4 P16422 EPCAM Epithelial cell adhesion molecule 1 20687990.0 7297400.0 9857300.0 3533290.0 True False 6068111.429633745 9804196.76837914 4272084.602912857 1.0 1.6156916170820705 0.704022108435591 22.532816147576224 -6.724759693883085 1.7421086922231428 1.372645484384849 0.7050342288763993 0.5350159432868216 0.2589435334398174 0.34609850664265185 2.055211453508305 0.11790604984097518 0.294353162778404 1.8846916485650413e-07 6.724759693883085 -0.6676112555084497 AEIK(ub)EMGEMHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEIKEMGEMHR 11 1 P16422;B5MCA4 P16422 EPCAM Epithelial cell adhesion molecule 1 28454700.0 12898000.0 10308000.0 5248700.0 True False 16696715.257589947 9734350.738539755 4293490.456209895 1.0 0.5830099267048793 0.25714581520806445 23.99306097363573 -7.896136799590448 0.272379267570148 1.1418898300304388 1.171206359368558e-15 0.9995277751493015 0.006606762362444222 0.11152474436604069 0.046104655046333966 0.05359247274682389 0.08892165593881425 1.2701739466703393e-08 7.896136799590448 -1.1418898300304376 down AEIK(ub)FSSYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEIKFSSYR 9 1 Q9H7Z7;X6RJ95 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 15225000.0 5820500.0 4695800.0 4708700.0 True False 7630731.865802187 3995204.944085036 4221488.89303979 1.0 0.52356772775491 0.5532220194970778 22.863390002337834 -10.137589288794056 5.874239655721866 1.0000039651842 0.5383948736259792 0.9969143045856348 0.01210631390870897 6.286784848506206e-07 9.232835060939839e-08 0.0117219886139145 0.003907296012691439 7.284683896240462e-11 10.137589288794056 -0.46160909155822094 AEIK(ub)FSSYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEIKFSSYR 9 1 Q9H7Z7;X6RJ95 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 20760500.0 7827100.0 4894900.0 8038500.0 True False 7578632.994837933 6849459.096566287 5932975.700169151 1.0 0.9037855641290043 0.7828556553946211 22.853506213311054 -6.968028943196003 0.3015719380733896 1.0205853236959121 0.6622581534312132 0.9999626650347099 0.0005428025905851125 0.07694759988215102 0.011307140646844878 0.001990787028586842 0.010827739196775456 1.0763934758878284e-07 6.968028943196003 -0.35832717026469896 AEIK(ub)FSSYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEIKFSSYR 9 1 Q9H7Z7;X6RJ95 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 40200200.0 19293200.0 5126500.0 15780500.0 True False 29269194.921851907 4211636.021472679 12661477.25816116 1.0 0.14389312834595053 0.43258713784123615 24.80287972775029 -10.377592283689701 5.834897854706554 1.0001662065166064 0.2882401332317692 0.8901650954010201 0.1178588358436125 0.00025488520431604493 2.71884279238976e-05 0.1141423998975918 0.038038775702141495 4.191869137535693e-11 10.377592283689701 -0.7119260732848371 AEIK(ub)FSSYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEIKFSSYR 9 1 Q9H7Z7;X6RJ95 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 14192100.0 5820500.0 5519600.0 2852000.0 True False 7972496.143098161 5275725.821123664 2178416.3387837512 1.0 0.6617407806074503 0.2732414415364277 22.926600063860725 -7.320461944077756 0.33468019142651884 1.0579159383171683 4.26341519233413e-15 0.9997514619445952 0.004681190068913087 0.10613516336754912 0.02565627725396961 0.013153944111993157 0.05160004700690773 4.781212606448993e-08 7.320461944077756 -1.0579159383171641 down AEIK(ub)FSSYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEIKFSSYR 9 1 Q9H7Z7;X6RJ95 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 39834500.0 19293200.0 18634800.0 1906500.0 True False 24975427.72582837 17597756.998694275 1559536.562341946 1.0 0.7046028277023474 0.062442836994104786 24.57400604984274 -7.370313428648669 0.6517526041953099 0.9971722333084235 2.7078873341859583e-22 0.9939155685575372 0.03052913859137525 0.1070889976937247 0.09374537256799526 0.027868363700542288 0.06689118969886378 4.262717690762203e-08 7.370313428648669 -0.9971722333084235 down AEINILLCGDPGTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEINILLCGDPGTSK 15 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 10702400.0 3905200.0 4202400.0 2594800.0 False True 5119755.0180106005 3575418.3008268964 2326314.9870791645 1.0 0.6983573019117247 0.4543801371150583 22.287643347760962 -7.287138877348099 0.17571800841485624 1.2225171266226829 1.7418607109377996e-15 0.9999887382650469 0.0007488783930110455 0.10549226644111674 0.010215499265914595 0.02053253181197078 0.045566786547254344 5.162512576413146e-08 7.287138877348099 -1.222517126622681 down AEINILLCGDPGTSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEINILLCGDPGTSK 15 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 16041400.0 7646700.0 3798600.0 4596100.0 False True 7403959.694091959 5315400.789437304 3392243.529955525 1.0 0.7179132530500896 0.4581661259801818 22.81986561076552 -6.972113612029903 0.20140390017480744 1.1518345736945976 0.017062275381226833 0.9999945137621159 0.0005182316124570608 0.07562267421653099 0.0065143239934546335 0.008336512357924505 0.027478192387663695 1.066317134720721e-07 6.972113612029903 -1.1347722983133708 down AEINILLCGDPGTSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEINILLCGDPGTSK 15 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 157513000.0 29567000.0 71803000.0 56143000.0 False True 44855300.637239836 58989193.6506004 45046311.44164889 1.0 1.3150997276256422 1.0042583775316507 25.418775145480918 -10.700305908669172 6.566942898947754 0.998281406436786 1.1596790525783147 0.26027273827833597 0.12690044978135118 0.0032252278851727023 0.00014718890482924782 0.12411006379121353 0.0409569440524503 1.9938573854807936e-11 10.700305908669172 0.16139764614152874 AEINILLCGDPGTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEINILLCGDPGTSK 15 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 11913900.0 3905200.0 3507800.0 4500900.0 False True 5349057.97406184 3352813.7972566034 3437880.1189452317 1.0 0.6268045352125102 0.6427075824595441 22.350853409283854 -10.032791257085202 7.39163714840294 1.0000000259016126 0.6347560588436831 0.9985801606836309 0.006492391851767745 2.7729702651351163e-09 3.611725697255516e-10 0.006286231848096773 0.0020954104599124205 9.272754096570497e-11 10.032791257085202 -0.3652439670579295 AEINILLCGDPGTSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEINILLCGDPGTSK 15 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 18367500.0 7646700.0 2174200.0 8546600.0 False True 6358569.856247482 2162487.1530550905 10333654.54498641 1.0 0.3400901778141799 1.6251538913004613 22.600270886199795 -6.767108528637658 1.5854684357387367 0.6201058603467889 1.6316175858983855 0.7194299231678206 0.2779218240014932 0.27111397614495786 1.3445034070118977 0.13820672823651622 0.3298769166953769 1.70958804176863e-07 6.767108528637658 1.0115117255515966 AEINILLCGDPGTSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEINILLCGDPGTSK 15 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 109098000.0 29567000.0 46306000.0 33225000.0 False True 38275064.3527029 43729030.39375462 27178390.917288803 1.0 1.1424939744266314 0.7100808679729763 25.189901467573367 -6.8179104898977725 1.3808490422633928 1.0769708006077998 0.701054541790547 0.8795117195408902 0.06245256191236639 0.1962161505448462 0.7357047893016797 0.03554562984249281 0.08197776808338662 1.5208609539120177e-07 6.8179104898977725 -0.37591625881725277 AEISHHISSCDDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEISHHISSCDDR 13 0 Q8WW33;G3V1V4 Q8WW33 GTSF1 Gametocyte-specific factor 1 0 6058570.0 663570.0 2980100.0 2414900.0 False True 869946.6960210201 2535480.696338819 2165029.313356507 1.0 2.9145241977878094 2.4886919201589732 19.730567480292358 -10.071663844764931 5.249082400740688 0.9999771996382457 2.7016080589760456 0.9551373247438432 0.1738452993755834 4.638725716432984e-05 8.204307496259554e-06 0.16832723158327287 0.056108329106836 8.478834440745542e-11 10.071663844764931 1.7016308593377998 AEISHHISSCDDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEISHHISSCDDR 13 0 Q8WW33;G3V1V4 Q8WW33 GTSF1 Gametocyte-specific factor 1 0 5188070.0 663570.0 1996200.0 2528300.0 False True 908909.7613049801 1908001.2834493548 1931167.6119729904 1.0 2.099219707696741 2.1247077478849925 19.79377754181525 -10.924140617004063 0.6528458814909628 1.3848528125545287e-22 2.120854686657474 0.9999465158426853 0.00383426390038354 2.760418822345438 0.32738396809524145 4.209925023864783 0.004163112227108878 1.1908563670073839e-11 10.924140617004063 2.120854686657474 AELAK(ub)ETDPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AELAKETDPLR 11 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 3663420.0 830120.0 1134400.0 1698900.0 True False 690281.5605513699 1128288.762039229 2054132.1351739203 1.0 1.6345341184226276 2.975788797738071 19.39682542061131 -6.958948433170228 0.4500082291525021 0.9567509851496612 3.7067441729762365 0.999729190007455 0.013553951940173772 0.08007890905013496 0.02253549857283202 0.017927448273485202 0.1109437487194932 1.0991363398512045e-07 6.958948433170228 2.7499931878265755 AELDDTPMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AELDDTPMR 9 0 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 8615980.0 2592100.0 659480.0 5364400.0 False True 2509815.204343805 922813.8031427672 3959302.7114495793 1.0 0.3676819717824756 1.5775275823483366 21.259149712945863 -6.76469607810229 1.5949491810291836 0.6348680197128843 1.582981094704382 0.7098051688789385 0.2661629273379221 0.2750868217447277 1.380187022419046 0.13161088919351302 0.31481305184150277 1.719111010560277e-07 6.76469607810229 0.9481130749914978 AELDEVNK(ub)SAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AELDEVNKSAK 11 1 Q03252 Q03252 LMNB2 Lamin-B2 1 3399270.0 1426800.0 1429800.0 542670.0 True False 1870548.617150854 1216479.413316748 486519.7140582124 1.0 0.6503329569533678 0.26009466399181863 20.83503003257241 -7.384238876346405 0.33804994472777034 1.0590175868048506 1.2685331691475129e-13 0.9996596325593328 0.005575602784792412 0.11321821975589387 0.029895156215156385 0.015587885890071294 0.05689466301621136 4.128203746557911e-08 7.384238876346405 -1.0590175868047238 down AELDEVNK(ub)SAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AELDEVNKSAK 11 1 Q03252 Q03252 LMNB2 Lamin-B2 1 6445100.0 2527300.0 3917800.0 0.0 True False 3834098.8703790097 3218637.980088888 0.0 1.0 0.8394770424297165 0.0 21.870456109764337 -7.192578169843204 0.8988640238575105 0.9911422086763979 1.4749326213101441e-19 0.9894144076565449 0.045114981804362984 0.0920194611651809 0.1412406367728206 0.037977887897992245 0.06666645677720355 6.418326859024147e-08 7.192578169843204 -0.9911422086763979 down AELDEVNK(ub)SAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AELDEVNKSAK 11 1 Q03252 Q03252 LMNB2 Lamin-B2 1 3678380.0 1393300.0 1789200.0 495880.0 True False 1158590.6836556434 1779561.2244716054 599566.2153099325 1.0 1.535970597361136 0.5174961474902863 20.14393953863707 -6.763717809359323 1.598375209334954 1.3098853639523134 0.5130653648172963 0.7059577482161644 0.225568666433129 0.27673658951129004 1.394200869646508 0.11130236606563533 0.26651532414263723 1.7229877535856716e-07 6.763717809359323 -0.7968199991350171 AELEIQK(ub)DALEPGQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AELEIQKDALEPGQR 15 1 P07741-2;P07741;H3BQB1;H3BQZ9 P07741-2 APRT Adenine phosphoribosyltransferase 1 119596000.0 7602000.0 11124000.0 100870000.0 True False 9840938.857822811 10504939.621218124 82512695.01360205 1.0 1.0674733145880164 8.384636486996422 23.2303645292903 -6.908917930190545 0.9030626983339324 0.7656162179283564 9.308721154455117 0.9905069046747712 0.3376384435963846 0.10513845398455535 0.1426776051644405 0.2749579525005581 0.7534456697348874 1.2333378784219862e-07 6.908917930190545 8.543104936526762 up AELHQLSGGEKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 AELHQLSGGEKK 12 1 Q9UNQ0-2;Q9UNQ0 Q9UNQ0-2 ABCG2 ATP-binding cassette sub-family G member 2 1 5138230.0 296350.0 1283000.0 3558880.0 True False 449584.61608705716 1054038.6258752458 2855465.808087483 1.0 2.344472182008876 6.351342341159096 18.778233144616134 -6.951599026066646 0.5410043073960917 0.9413951011687485 7.939775511605844 0.999320867808465 0.05923521158566998 0.08284994110029544 0.03335369249918601 0.06506251859119712 0.3318791808912629 1.11789489766026e-07 6.951599026066646 6.998380410437095 AELHQLSGGEKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AELHQLSGGEKK 12 1 Q9UNQ0-2;Q9UNQ0 Q9UNQ0-2 ABCG2 ATP-binding cassette sub-family G member 2 1 3154560.0 296350.0 649610.0 2208600.0 True False 383630.9169318328 613458.6324469169 1806657.462149711 1.0 1.5990854891289226 4.7093635638097835 18.549359466708584 -6.938969336539134 0.6690821377346999 0.9643889719010754 5.523276071808748 0.9980257795172688 0.07224254894837161 0.0882399684866038 0.05677433729350218 0.06978529402835495 0.2689338047992388 1.1508816443366477e-07 6.938969336539134 4.558887099907673 AELIK(ub)THHNDTELIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AELIKTHHNDTELIR 15 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 24442300.0 9919500.0 9809400.0 4713400.0 True False 13004560.560574649 8345875.756741724 4225702.582125373 1.0 0.6417653036307545 0.3249400517950794 23.632514313950647 -7.513648360802439 0.2539921382032485 1.1296582333780623 1.8397335547699524e-11 0.999852673882803 0.0033471728016786885 0.12678797671090972 0.025587364626320056 0.02716111385996108 0.06612749577958668 3.064443645668253e-08 7.513648360802439 -1.129658233359665 down AELIK(ub)THHNDTELIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AELIKTHHNDTELIR 15 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 28881200.0 8957800.0 10281500.0 9641900.0 True False 8673439.542251825 14386956.567314181 7116397.139200214 1.0 1.6587371707878413 0.8204815522761612 23.048172791896032 -6.697176368235162 1.8413804040606456 1.4101845365030727 0.8231375853184615 0.40402354924702855 0.27820806518129 0.40140510010774416 2.6441378322232034 0.12063759556271512 0.31128311053486996 2.0082770799000223e-07 6.697176368235162 -0.5870469511846113 AELIK(ub)THHNDTELIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AELIKTHHNDTELIR 15 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 77736900.0 20829500.0 28963500.0 27943900.0 True False 31599874.34042637 23794737.13214165 22420775.91675352 1.0 0.7530010048711033 0.709521046672966 24.91341548562644 -13.999999999999998 0.24434882909719577 2.6700315733481057 0.6910739610706529 0.9995323939304527 0.002766211499284553 13.780910042707191 0.15643244538636442 11.258568931798008 0.020716220225809292 1.0000000000000041e-14 13.999999999999998 -1.9789576122774528 AELIK(ub)THHNDTELIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AELIKTHHNDTELIR 15 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 21886700.0 9919500.0 7491400.0 4475800.0 True False 13587007.214408066 7160405.177253026 3418708.221994504 1.0 0.527003854804752 0.2516159863644736 23.69572437547354 -8.750027037422798 0.22094849732713293 1.3175971367650805 5.202255587422889e-13 0.9995005184039172 0.006907124259204921 0.2926218174609196 0.0652049132568519 0.1916382231265808 0.12418680852624964 1.7781687049812693e-09 8.750027037422798 -1.3175971367645603 down AELIK(ub)THHNDTELIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AELIKTHHNDTELIR 15 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 31250230.0 8957800.0 18313100.0 3979330.0 True False 7448807.597825698 18214443.695434254 4811389.504656922 1.0 2.4452831485070226 0.6459274778504634 22.82857806733031 -6.692853646119943 1.8561066246107354 1.9036477359604882 0.6518881069726598 0.3839213848969538 0.6109004103009614 0.4105462834622583 2.744367990483325 0.26307508541646474 0.6826546013096605 2.028366148057206e-07 6.692853646119943 -1.2517596289878283 AELIK(ub)THHNDTELIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AELIKTHHNDTELIR 15 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 83002300.0 20829500.0 33703200.0 28469600.0 True False 26964198.36082878 31827587.29250617 23288424.92276439 1.0 1.1803646771395397 0.8636794838520314 24.68454180771889 -6.752182806436856 1.6414743456530245 1.1057740573032162 0.8629318060004585 0.658455317309611 0.07580039811349669 0.2962391633140638 1.5710486190457975 0.036466706715728374 0.08833953014425149 1.7693640277894642e-07 6.752182806436856 -0.24284225130275772 AELIVQPELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AELIVQPELK 10 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 6374790.0 924190.0 2539400.0 2911200.0 False True 1211622.03986869 2160531.418503672 2609976.950202273 1.0 1.7831727613157484 2.154118086598301 20.208508295983815 -9.941510895840162 0.18075651789918942 1.9990852818433644e-15 2.558437078931684 0.9995523634575834 0.010178428138594639 1.4623491641859085 0.08212071853268406 0.971085309734996 0.2536857499542762 1.144166173930413e-10 9.941510895840162 2.5584370789316817 AELIVQPELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AELIVQPELK 10 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 5953190.0 924190.0 2160600.0 2868400.0 False True 1265888.0182956578 2065137.5478512526 2190942.9965523533 1.0 1.631374590804385 1.7307557737232977 20.271718357506707 -11.383501454385106 0.32258406142886525 7.278569055004196e-08 1.752870073391948 0.9994054376811741 0.007890805503267921 3.6352084267671048 0.16786762861847737 2.595632193004749 0.03268926335249539 4.135219295242485e-12 11.383501454385106 1.7528700006062574 AELIVQPELK(ub)YGDGIQLTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AELIVQPELKYGDGIQLTR 19 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 130563500.0 7431500.0 14932000.0 108200000.0 True False 11274128.815424193 12267267.935751494 86814222.57425526 1.0 1.08809009871952 7.700304298056651 23.426512620776332 -6.909804315756789 0.8970677593230832 0.7940035344344056 8.551250940285776 0.9908474792609874 0.30020841008119287 0.10454753429994895 0.139470736364753 0.24554707867479816 0.6769043906944713 1.230823229753864e-07 6.909804315756789 7.75724740585137 up AELIVQPELK(ub)YGDGIQLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AELIVQPELKYGDGIQLTR 19 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 100566500.0 7431500.0 19218000.0 73917000.0 True False 9620223.246765345 18148501.406020284 60464864.45246771 1.0 1.8864948287060224 6.285183087907872 23.19763894286878 -6.939976032267947 0.6597859295127412 0.9506063060749496 7.470535551037657 0.9981607671979573 0.09911122105409002 0.08777755410988464 0.05465935537118082 0.09645986295100725 0.3786262480516424 1.1482169872518302e-07 6.939976032267947 6.519929244962707 AELLDNEK(ub)PAAVVAPITTGYTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AELLDNEKPAAVVAPITTGYTVK 23 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 5200400.0 1738400.0 2420300.0 1041700.0 True False 2381133.4584935685 2313363.1431381945 795671.9144849351 1.0 0.9715386321108397 0.33415679060186715 21.18321705280977 -6.91624882435093 0.8520897347806773 1.016053099404364 0.2397485037765729 0.9930737080440163 0.025582562031622284 0.10042961864190021 0.11742511485760217 0.021614802882756107 0.0625958682254638 1.2126938514927838e-07 6.91624882435093 -0.7763045956277911 down AELLDNEKPAAVVAPITTGYTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AELLDNEKPAAVVAPITTGYTVK 23 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 22820800.0 7010300.0 3087500.0 12723000.0 False True 6787761.863744215 4320354.851099795 9390464.618181523 1.0 0.6364918124450277 1.3834404928580721 22.69450452076607 -6.774348455648832 1.5575903444313093 0.7926654990236729 1.3883739289188441 0.7470044840179837 0.1533991974269491 0.2594469032546555 1.2427349444391023 0.0775982430375728 0.1840057395860714 1.681324511063406e-07 6.774348455648832 0.5957084298951713 AELMEISEDK(ub)TKIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AELMEISEDKTKIR 14 2 P05455;E7ERC4;E9PFL9;E9PGX9 P05455 SSB Lupus La protein 1 16024900.0 4258500.0 4267200.0 7499200.0 True False 5512712.197584646 4029726.56882973 6134422.548289913 1.0 0.7309880190363148 1.1127775817822785 22.394330853873882 -6.717376176861724 1.768613363503804 0.8358747068356207 1.1121000064330033 0.5000640635800784 0.1132401383210918 0.3604958865743367 2.2022725271253996 0.05086541442849462 0.12809387554390597 1.917007549198576e-07 6.717376176861724 0.2762252995973826 AELNEFLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AELNEFLTR 9 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82;E9PQX2;H0YES8 P23396 RPS3 40S ribosomal protein S3 0 18528300.0 2062300.0 16466000.0 0.0 False True 2703695.2713416093 14009336.983965304 0.0 1.0 5.181551757130412 0.0 21.366501126529208 -6.692049151950903 1.8593919702598918 3.6168384995128102 0.017837459104455416 0.37955401442535774 1.7678363280355551 0.4125004569439116 2.766694997961208 0.7601781323235218 1.9742712744686084 2.03212700879816e-07 6.692049151950903 -3.599001040408355 AELNEFLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AELNEFLTR 9 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82;E9PQX2;H0YES8 P23396 RPS3 40S ribosomal protein S3 0 24315500.0 7777400.0 2381100.0 14157000.0 False True 7530510.6941335285 3331885.647272463 10448856.999103647 1.0 0.4424514860417225 1.3875363070984799 22.844316276307758 -6.746847486062195 1.6613822890328234 0.6709109444714235 1.38898332900187 0.6352916233454238 0.2342598377684183 0.3056052982874254 1.6586065265239396 0.11143052673298276 0.27143843390056815 1.7912347828350706e-07 6.746847486062195 0.7180723845304465 AELNEFLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AELNEFLTR 9 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82;E9PQX2;H0YES8 P23396 RPS3 40S ribosomal protein S3 0 33950300.0 2062300.0 15587000.0 16301000.0 False True 2824788.041561949 14898314.800683813 12451039.529633239 1.0 5.2741354683892965 4.407778334670559 21.4297111880521 -10.199507751578556 5.281526803597547 0.999772694450714 4.840956901531001 0.9632452736461352 0.35368881877563674 0.0009467221278596401 0.00014349095154740226 0.3424753194730676 0.11415257540427123 6.316729046661597e-11 10.199507751578556 3.8411842070802873 AELQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AELQLR 6 0 J3KRP8;J3QQT0;Q7RTP6 REV__A0A0U1RQJ2 MICAL3 Protein-methionine sulfoxide oxidase MICAL3 0 7239900.0 2246900.0 1008300.0 3984700.0 False True 2175573.3893908774 1410919.4482150376 2940987.531562361 1.0 0.6485276272891306 1.3518217982918912 21.052964253968387 -6.770822396873978 1.5712183818389112 0.7986151901249967 1.3559084268722164 0.7337128857474691 0.14816188202563357 0.2651098633391583 1.2917467411903907 0.07432096438102617 0.17678790300350627 1.6950308353368448e-07 6.770822396873978 0.5572932367472196 AEMSNGAPQELEK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEMSNGAPQELEKK 14 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-9;Q9UKT9-10;Q9UKT9-11;Q9UKT9-16;Q9UKT9-12 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 6199880.0 467590.0 908790.0 4823500.0 True False 613015.0181480019 773202.0744356744 4324410.490279152 1.0 1.2613101662201007 7.054330419740382 19.22556289311998 -6.9163363629978285 0.8514455109413824 0.8545382637111668 7.914111421096678 0.9931014458078038 0.2321029802870892 0.1003758902386928 0.11713532776988678 0.19619327989484445 0.5686053925294883 1.2124494392675135e-07 6.9163363629978285 7.059573157385511 up AEMSNGAPQELEK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEMSNGAPQELEKK 14 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-9;Q9UKT9-10;Q9UKT9-11;Q9UKT9-16;Q9UKT9-12 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 7619490.0 467590.0 1020100.0 6131800.0 True False 640470.6591446216 975028.6089804054 4683595.1283850735 1.0 1.5223626485600472 7.3127395634957475 19.288772954642873 -6.924569290558968 0.7900869937982721 0.8920273723101148 8.352265977434707 0.9953592090308462 0.1948798988872774 0.09555705846992375 0.09222128083018827 0.17211012303338194 0.5404138107774517 1.1896815034169286e-07 6.924569290558968 7.460238605124592 up AEMSNGAPQELEKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEMSNGAPQELEKK 14 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-9;Q9UKT9-10;Q9UKT9-11;Q9UKT9-16;Q9UKT9-12 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 22505500.0 2113300.0 4293800.0 16098400.0 True False 2770556.765226312 3653181.777101306 14432691.9947569 1.0 1.3185731557472338 5.209311058305629 21.401744495676827 -6.923141395749969 0.8010834382081187 0.9234800354641355 5.884418693388478 0.995009993566618 0.13517839438211995 0.09635845082110227 0.09629344389537366 0.11845140047032063 0.3662128759976809 1.1935994341705817e-07 6.923141395749969 4.960938657924343 up AEMSNGAPQELEKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEMSNGAPQELEKK 14 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-9;Q9UKT9-10;Q9UKT9-11;Q9UKT9-16;Q9UKT9-12 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 5405200.0 2113300.0 2270300.0 1021600.0 True False 2894644.1197851268 2169990.639121864 780319.1205124402 1.0 0.7496571424064887 0.2695734218859223 21.464954557199718 -6.999173505656315 0.4328840262605414 1.0188416845882116 1.587874415124925e-15 0.9997972695800136 0.004315242390189187 0.07487959244214164 0.020334371313650755 0.0061857161775175345 0.03753684185891535 1.0019048855489616e-07 6.999173505656315 -1.01884168458821 down AEMTLK(ub)TNFFATR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEMTLKTNFFATR 13 1 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 1 23956300.0 9803600.0 8199700.0 5953000.0 True False 14872777.9391634 6736399.470451493 4776386.940707413 1.0 0.45293485171408526 0.3211496171223065 23.82617080351515 -13.99999999999999 0.1999368869010259 4.040329906471768 0.2355090358547105 0.9994869269246547 0.006657548428258112 12.529635538083204 0.14178194754824416 14.89682824007364 0.08395335604184825 1.0000000000000246e-14 13.99999999999999 -3.804820870617057 AEMTLK(ub)TNFFATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEMTLKTNFFATR 13 1 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 1 9754300.0 3594400.0 4319500.0 1840400.0 True False 2988902.8589190026 4296229.996146383 2225219.1309518414 1.0 1.4373936520975465 0.7444936272558008 21.511184578674342 -6.7361015155282695 1.7010528021784994 1.2614146346446862 0.744428151449281 0.5873030417156428 0.18379844123632946 0.3249039100987923 1.8444025849561143 0.08553432664323621 0.2107917238917607 1.836109106091352e-07 6.7361015155282695 -0.5169864831954052 AEMTSK(ub)HQEYLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEMTSKHQEYLK 12 1 Q9NR28-2;Q9NR28;Q9NR28-3;H7BZK7;A0A2U3TZH2;H7BZQ7 Q9NR28-2 DIABLO Diablo homolog, mitochondrial 1 21223300.0 983400.0 2013900.0 18226000.0 True False 952182.5052859449 2818060.7723497567 13452063.831720216 1.0 2.959580497126945 14.127610785792056 19.860878596537244 -6.936932987951808 0.6875025768397215 0.8655350057908029 16.885678718129835 0.9977339773166893 0.275246153897429 0.08919409097039979 0.06119240243379908 0.2620715560567482 0.9749055275091217 1.1562906451650543e-07 6.936932987951808 16.02014371233903 AEMTSK(ub)HQEYLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 AEMTSKHQEYLK 12 1 Q9NR28-2;Q9NR28;Q9NR28-3;H7BZK7;A0A2U3TZH2;H7BZQ7 Q9NR28-2 DIABLO Diablo homolog, mitochondrial 1 246062030.0 3216030.0 78035000.0 164811000.0 True False 4878952.633286515 64109044.559762225 132236033.61077254 1.0 13.13991944139406 27.10336491250109 22.21814004642817 -7.378998366758449 0.37489316284456087 3.0140124067651715e-17 34.94094030240872 0.9988985598035699 0.35396007504653404 0.1481185408470118 0.046059932350839036 0.6546191980858761 2.5620897394355695 4.178319379748975e-08 7.378998366758449 34.94094030240872 AEMTSK(ub)HQEYLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEMTSKHQEYLK 12 1 Q9NR28-2;Q9NR28;Q9NR28-3;H7BZK7;A0A2U3TZH2;H7BZQ7 Q9NR28-2 DIABLO Diablo homolog, mitochondrial 1 13749100.0 983400.0 2159700.0 10606000.0 True False 817740.6720067187 2148065.2674331134 12823665.563396681 1.0 2.6268294350112313 15.681824326931999 19.64128387197152 -6.93003804414556 0.7464790696363275 0.8017553040090639 18.364552515307636 0.9965457411894522 0.3862134358146757 0.09261801928411223 0.07758318093497359 0.35193898430015397 1.1810042333839632 1.174794638559633e-07 6.93003804414556 17.562797211298573 AEMTSK(ub)HQEYLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AEMTSKHQEYLK 12 1 Q9NR28-2;Q9NR28;Q9NR28-3;H7BZK7;A0A2U3TZH2;H7BZQ7 Q9NR28-2 DIABLO Diablo homolog, mitochondrial 1 217978030.0 3216030.0 44901000.0 169861000.0 True False 4163214.2324288255 42402219.87884887 138948040.92104122 1.0 10.184971877873158 33.375183971731076 21.98926636852062 -6.955250132754845 0.4978878910236686 0.5269476786494597 44.029826787815836 0.9995514547389777 0.28852231343753104 0.08144365200776664 0.02774954291718363 0.3397214471885126 1.9128590115510227 1.1085361677945858e-07 6.955250132754845 43.50287910916638 AENDDTYK(ub)DDVNHNQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AENDDTYKDDVNHNQK 16 1 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 65847000.0 12521000.0 11947000.0 41379000.0 True False 12123527.708648896 16717499.402781947 30540598.556608744 1.0 1.378930275455693 2.5191181387593278 23.53130622005563 -6.951383954422929 0.5434424521838174 0.9835831574952322 2.967430273237901 0.9993054334626598 0.0170148708145007 0.0829348276426617 0.0336996032866845 0.018627186401291837 0.09447708893623519 1.1184486395228314e-07 6.951383954422929 1.9838471157426687 up AENDDTYKDDVNHNQK(ub)CK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AENDDTYKDDVNHNQKCK 18 2 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 290666000.0 73173000.0 87333000.0 130160000.0 True False 100227035.52597219 83474339.28838907 99418888.72934553 1.0 0.8328525217804937 0.9919368382753649 26.578696476796164 -10.576133219905541 7.562768666182813 1.000054566246062 0.9123946800311632 0.28792090414906846 0.0649459002486433 5.9790061832575805e-05 3.3509957691885804e-06 0.0629227098501741 0.020961199172286955 2.6537913861525342e-11 10.576133219905541 -0.08765988621489884 AENDDTYKDDVNHNQK(ub)CK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AENDDTYKDDVNHNQKCK 18 2 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 298134000.0 127230000.0 126460000.0 44444000.0 True False 164701743.07824203 119422389.83272576 36355648.03394992 1.0 0.7250827319780934 0.2207362675978424 27.295280582633286 -7.143147463583478 0.4614068485448398 1.0156171111464953 8.695490177512288e-13 0.9995531260819445 0.006821603895166734 0.08077953493374065 0.02822726704247932 0.008629494722340996 0.04254279016392641 7.19204732407309e-08 7.143147463583478 -1.0156171111456258 down AENDDTYKDDVNHNQK(ub)CK(ub)EK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AENDDTYKDDVNHNQKCKEK 20 3 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 2 48931000.0 12200000.0 13881000.0 22850000.0 True False 10144840.551639171 13806220.297837213 27627829.353537064 1.0 1.3609105266426733 2.7233379581380457 23.274242854375878 -6.946206045575619 0.5990500857215432 0.9846216519781221 3.169256339370664 0.9988689155401722 0.024957875458588814 0.08504592854562908 0.042549814223355985 0.025639352539872984 0.11445963556222549 1.1318632374975436e-07 6.946206045575619 2.184634687392542 up AENDDTYKDDVNHNQKCK(ub)EK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 AENDDTYKDDVNHNQKCKEK 20 3 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 2 7718500.0 1015000.0 2797300.0 3906200.0 True False 1330674.8292739817 2379953.743789996 3502023.8949162266 1.0 1.7885314213755006 2.6317653403175414 20.343726639065498 -6.970272432557801 0.2515945670803428 0.7375919519670379 3.707452227292244 0.9999844301218545 0.0026290870661955026 0.07621439944011822 0.008713302852421828 0.018605858252963885 0.08060708929406847 1.0708473528716463e-07 6.970272432557801 2.9698602753252064 AENDDTYKDDVNHNQKCK(ub)EK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 AENDDTYKDDVNHNQKCKEK 20 3 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 2 6288300.0 1388400.0 2128000.0 2771900.0 True False 1344326.0019717382 2977721.497373398 2045856.2347824683 1.0 2.215029310603187 1.521845320094819 20.358451606545277 -10.089745902555675 4.851388035287045 0.9999726158372586 1.8684373153537572 0.6766638137830971 0.2829911791485229 0.00010199901775907489 1.913722949719579e-05 0.27401550579975287 0.09133501032368518 8.133062269962536e-11 10.089745902555675 0.8684646995164986 AENDDTYKDDVNHNQKCK(ub)EK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 AENDDTYKDDVNHNQKCKEK 20 3 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 2 6443800.0 2099700.0 2006200.0 2337900.0 True False 3185398.408631662 1648177.935487855 1875813.0402620283 1.0 0.5174165752772684 0.5888786266669271 21.603042395875033 -10.632587120160107 6.571182754072773 1.0017211824700962 0.5531476009721517 0.9811794422061973 0.029174260312868922 0.00073798367192455 4.12626198123512e-05 0.028337405043382953 0.009415952027471778 2.3303056054016984e-11 10.632587120160107 -0.4485735814979446 AENDDTYKDDVNHNQKCK(ub)EK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AENDDTYKDDVNHNQKCKEK 20 3 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 2 25631200.0 1015000.0 20467400.0 4148800.0 True False 1390272.9293436343 19563082.59135921 3168938.887218108 1.0 14.071397190043248 2.2793645911772193 20.40693670058839 -9.170059684006947 9.496570668382809 0.9995670580473406 8.175380890616426 0.33051550285397635 4.814077156093117 0.0 0.0 4.661210160284192 1.5537367200947303 6.759900693797793e-10 9.170059684006947 7.1758138325690854 AENFFILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AENFFILR 8 0 F8WDD7;F8WCF6;A0A0A6YYG9;P59998;P59998-3;P59998-2;R4GN08;P59998-4 F8WDD7 ARPC4;ARPC4-TTLL3 Actin-related protein 2/3 complex subunit 4 0 8410300.0 1633600.0 2633900.0 4142800.0 False True 2141665.4198049046 2240932.386861789 3714142.796543688 1.0 1.046350361797375 1.734231109209406 21.0303016829834 -6.9205557130942825 0.8205949181768828 0.9851244290090239 1.8465884452439296 0.9943339218179134 0.025271422444880936 0.0978458045373747 0.1039279846943702 0.021838249555366833 0.06576749823877372 1.2007270288994414e-07 6.9205557130942825 0.8614640162349058 AENFFILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AENFFILR 8 0 F8WDD7;F8WCF6;A0A0A6YYG9;P59998;P59998-3;P59998-2;R4GN08;P59998-4 F8WDD7 ARPC4;ARPC4-TTLL3 Actin-related protein 2/3 complex subunit 4 0 6320700.0 1633600.0 2011000.0 2676100.0 False True 2237586.066380062 1922147.3705122997 2044060.2960095361 1.0 0.8590272344794875 0.9135113624104705 21.09351174450629 -10.738334180612371 9.249435840358483 1.0004321320809264 0.8862692986736662 0.853150776395984 0.022243052085238222 0.0001989476147535606 5.6282196448368426e-06 0.02161675851393911 0.007178914191245982 1.826694071943457e-11 10.738334180612371 -0.11416283340726019 AENK(ub)VENETDEGDKAQDGENEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AENKVENETDEGDKAQDGENEK 22 2 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 4143000.0 1285000.0 1612000.0 1246000.0 True False 1760099.2258192794 1540776.5098288513 951720.4621755097 1.0 0.8753918456566906 0.540719777734411 20.74722533259709 -6.953908137701827 0.5141557877472097 1.005954875374372 0.3953698424592825 0.9994733455268713 0.004450429663944858 0.08195342185909035 0.029754138496071475 0.005090005084015925 0.027629672753447482 1.111966906491428e-07 6.953908137701827 -0.6105850329150895 AEPHFLSILQHLLLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEPHFLSILQHLLLVR 16 0 H9KV28;A0A140T8Z0;A0A0G2JH68;O60610-2;O60610-3;O60610;A0A2R8Y5N1 H9KV28 DIAPH1 Protein diaphanous homolog 1 0 1311540000.0 351980000.0 499430000.0 460130000.0 False True 533979393.18482345 410302814.4355993 369185103.81785697 1.0 0.7683869821051005 0.6913845525309867 28.99220882699731 -13.999999999999998 0.15387596513457694 2.1271581865444436 0.6103288938459875 0.9995538205886023 0.002770400346155101 11.974425701914713 0.12372745178166042 4.031729620722565 0.07334901389587387 1.0000000000000041e-14 13.999999999999998 -1.5168292926984561 AEPHFLSILQHLLLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEPHFLSILQHLLLVR 16 0 H9KV28;A0A140T8Z0;A0A0G2JH68;O60610-2;O60610-3;O60610;A0A2R8Y5N1 H9KV28 DIAPH1 Protein diaphanous homolog 1 0 1038000000.0 351980000.0 420670000.0 265350000.0 False True 455645048.5630725 397259344.7013504 217059022.72092098 1.0 0.8718614323894269 0.4763774420581126 28.76333514908976 -6.950811072205916 0.5498706994965721 1.005473622545018 0.32419022657332924 0.9992633825085323 0.0060486303600591155 0.08316175324127063 0.034627571692888846 0.006566130115487517 0.03280792260764623 1.1199249698739483e-07 6.950811072205916 -0.6812833959716889 down AEQQIK(ub)DNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEQQIKDNLR 10 1 Q13772;Q13772-3;Q13772-4;Q13772-2 Q13772 NCOA4 Nuclear receptor coactivator 4 1 6779230.0 481330.0 1200300.0 5097600.0 True False 466050.44261672185 1679586.04948181 3762385.6352780145 1.0 3.6038718042010216 8.07291505647638 18.830126586772526 -6.962922516490464 0.3920791746625197 0.7318065728239186 11.106092973762003 0.9998637044575521 0.03409884947429114 0.07867322358089038 0.01739138825343364 0.05763848075318311 0.37560025529297913 1.0891243892684017e-07 6.962922516490464 10.374286400938084 AEQQIK(ub)DNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEQQIKDNLR 10 1 Q13772;Q13772-3;Q13772-4;Q13772-2 Q13772 NCOA4 Nuclear receptor coactivator 4 1 8086160.0 481330.0 1449500.0 6155330.0 True False 400247.22153446643 1441691.2557967755 7442381.0439696815 1.0 3.602001908394578 18.594460232446103 18.610531862206802 -6.936697812045711 0.6895985372313594 0.8182938256308208 22.272763968791686 0.9976986192350218 0.3719764661950048 0.0893059089568894 0.0617148994097519 0.35360078256607375 1.3102411231786941 1.1569169606077465e-07 6.936697812045711 21.454470143160865 AERLDVLEQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AERLDVLEQQR 11 1 I3L2W0;I3NI49;I3L349;A0A0J9YWA6;I3L1Q0;I3L2X0;A0A0J9YX72;I3L2I9;I3L3M9;I3L2G8;I3L2N0;I3L308;Q9UNE2-2;Q9UNE2 I3L2W0 RPH3AL Rab effector Noc2 0 12432100.0 3615600.0 3168600.0 5647900.0 False True 4740086.613520205 2695857.231106062 5063509.486482352 1.0 0.5687358588378189 1.068231426835038 22.176481990421216 -6.678324893143704 1.9080289640664305 0.7267178285550432 1.0662960994503032 0.31634840002486675 0.1828485985679182 0.4422801929526231 3.11165826943495 0.07694032484391981 0.2033473205428701 2.0973702662443333e-07 6.678324893143704 0.33957827089526005 AERLDVLEQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AERLDVLEQQR 11 1 I3L2W0;I3NI49;I3L349;A0A0J9YWA6;I3L1Q0;I3L2X0;A0A0J9YX72;I3L2I9;I3L3M9;I3L2G8;I3L2N0;I3L308;Q9UNE2-2;Q9UNE2 I3L2W0 RPH3AL Rab effector Noc2 0 6858600.0 2408500.0 1093200.0 3356900.0 False True 2332043.4858462457 1529720.460962689 2477627.185158653 1.0 0.6559570909577563 1.0624275234128315 21.15316326019097 -6.682386857129535 1.8934690764917783 0.7827878508406546 1.0609082455808665 0.3350646783954333 0.1457380547711849 0.43323620731432155 3.0050921495178256 0.061715204423438204 0.16226997191237805 2.077844977497705e-07 6.682386857129535 0.2781203947402119 AERLDVLEQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AERLDVLEQQR 11 1 I3L2W0;I3NI49;I3L349;A0A0J9YWA6;I3L1Q0;I3L2X0;A0A0J9YX72;I3L2I9;I3L3M9;I3L2G8;I3L2N0;I3L308;Q9UNE2-2;Q9UNE2 I3L2W0 RPH3AL Rab effector Noc2 0 14602300.0 3615600.0 4779800.0 6206900.0 False True 4952385.027916103 4568612.631315105 4740958.0551181175 1.0 0.9225075606121674 0.9573080502412086 22.239692051944107 -10.087039562354938 4.393318030329149 1.000005548444111 0.9399078054810878 0.7990197323546983 0.014207240416124145 3149685.0752951954 7231663.520773193 97.62590933446174 0.004863516782713627 8.183902329170985e-11 10.087039562354938 -0.06009774296302328 AERPDVDEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 AERPDVDEKR 10 2 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6H2 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 1 2284140.0 380600.0 536640.0 1366900.0 True False 368518.06132990675 750923.1505406309 1008867.8838789839 1.0 2.0376834389899425 2.737634840035207 18.49137580299065 -8.179430909519267 0.1647470641732661 7.173550675254233e-11 3.9236473692805554 0.9998999330007295 0.007140777556725107 0.08822348046998377 0.03346659344286451 0.3344403820417284 0.3640944617279549 6.61559774481589e-09 8.179430909519267 3.92364736920882 AERPDVDEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 AERPDVDEKR 10 2 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6H2 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 1 6155030.0 423630.0 1197000.0 4534400.0 True False 642677.6815014681 983385.9977963126 3638173.8525018776 1.0 1.5301387088763658 5.660961874391101 19.293735846692726 -6.9305896909034255 0.7419361730106684 0.9385365945016315 6.5218739782125414 0.9966528543679801 0.12054076256150321 0.09233287692016857 0.07618877037640498 0.1102059333922189 0.3725639337376107 1.1733033457617545e-07 6.9305896909034255 5.58333738371091 up AERPDVDEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AERPDVDEKR 10 2 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6H2 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 1 3104600.0 694590.0 574110.0 1835900.0 True False 951398.6935889614 548743.9218721113 1402298.2315473673 1.0 0.5767759884156289 1.473933316281398 19.859690518704994 -6.778414958707514 1.5419268223129718 0.7598666261283165 1.4807046622790387 0.7617764158531315 0.17886134075579999 0.25304774354930015 1.1882083414415043 0.09137093695366272 0.21589520623637562 1.6656549557662687e-07 6.778414958707514 0.7208380361507223 AERPDVDEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AERPDVDEKR 10 2 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6H2 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 1 2166160.0 380600.0 774760.0 1010800.0 True False 316485.7634388416 770586.2141021803 1222153.6065888507 1.0 2.43482109820428 3.86163849302189 18.271781078424926 -6.971194363688575 0.22786160152471346 0.40397290938532676 5.933150896314615 0.9999902588276651 0.0036462360366481972 0.07591701000483755 0.007628866356201809 0.03724625614057232 0.14230632272662946 1.068576542588951e-07 6.971194363688575 5.529177986929288 AERPDVDEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AERPDVDEKR 10 2 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6H2 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 1 4270130.0 423630.0 897800.0 2948700.0 True False 548397.3859957224 847836.6407703732 2412066.8562169927 1.0 1.5460260431966875 4.398392329747187 19.064862168785176 -6.938832882793951 0.6703321270151851 0.9672457997820334 5.141878440371786 0.998007019308012 0.06652163224198866 0.08830311252710069 0.0570644788574305 0.06419499918335446 0.246786619169467 1.1512433039726548e-07 6.938832882793951 4.174632640589753 up AESEEMETSQAGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AESEEMETSQAGSK 14 0 P34932;A0A087WYC1 P34932 HSPA4 Heat shock 70 kDa protein 4 0 4835520.0 1503000.0 407520.0 2925000.0 False True 1455288.0877006045 570244.8611887258 2158854.751880919 1.0 0.3918432824456967 1.4834552485700405 20.472873345520355 -6.755499455378181 1.62942241663136 0.6447803189010543 1.4865792695236641 0.672333023937058 0.25565337618692346 0.2905400303614351 1.519227336726122 0.12385914050250667 0.29898945269372035 1.7559030961671146e-07 6.755499455378181 0.8417989506226099 AESEEMETSQAGSK(ub)DKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AESEEMETSQAGSKDKK 17 2 P34932;A0A087WYC1 P34932 HSPA4 Heat shock 70 kDa protein 4 1 2052600.0 667230.0 895460.0 489910.0 True False 874744.9914645117 761860.8584757409 439218.81274855556 1.0 0.8709519527516488 0.5021106917265209 19.738502973473246 -6.952534435463283 0.5302941025935622 1.0058049321960776 0.35050545387885346 0.9993854394654333 0.0052301172964386074 0.08248379801572721 0.031872450980144455 0.005832446361405149 0.03050234701281213 1.115489700013984e-07 6.952534435463283 -0.6552994783172241 AESEEMETSQAGSK(ub)DKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AESEEMETSQAGSKDKK 17 2 P34932;A0A087WYC1 P34932 HSPA4 Heat shock 70 kDa protein 4 1 3077370.0 1336900.0 873150.0 867320.0 True False 1294460.8412820604 1221803.348417098 640142.8729577299 1.0 0.9438704589989753 0.49452471063065867 20.303919892273537 -6.930084349524345 0.7461117272917479 1.006812268862854 0.40208176864346074 0.9965545039254844 0.013278566074460485 0.09259457025901993 0.07746943117412368 0.012103360978897904 0.04063939511355651 1.1746693861951204e-07 6.930084349524345 -0.6047305002193932 down AESEEMETSQAGSK(ub)DKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AESEEMETSQAGSKDKK 17 2 P34932;A0A087WYC1 P34932 HSPA4 Heat shock 70 kDa protein 4 1 2038210.0 667230.0 950770.0 420210.0 True False 913922.9622127623 908761.8376240556 320965.0524966063 1.0 0.9943527793894019 0.35119486627132723 19.801713034996137 -6.908822234947622 0.9037090856535983 1.0206631344448447 0.270135537743034 0.990469578418999 0.029729139133135078 0.10520254543506109 0.14302704817275427 0.024198725488821734 0.06626744661265327 1.233609669975648e-07 6.908822234947622 -0.7505275967018107 down AESFFQTK(ub)ALDVSASDDEIAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AESFFQTKALDVSASDDEIAR 21 1 C9JIF9;P13798;H7C393;H7C1U0;C9JLK2 C9JIF9 APEH Acylamino-acid-releasing enzyme 1 108390000.0 11839000.0 19800000.0 76751000.0 True False 17960628.546835367 16266535.301893895 61581131.208841614 1.0 0.905677396505148 3.4286735037283598 24.098334503462926 -6.898215694007724 0.9724936499856454 0.8899059062369461 3.684100548686959 0.9856570584126546 0.13985267230073276 0.11273012300263542 0.18492610564052964 0.10821026775860168 0.27910257862753923 1.264108367306818e-07 6.898215694007724 2.794194642450013 up AESQLLECK(ub)ASWEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AESQLLECKASWEER 15 1 P12270 P12270 TPR Nucleoprotein TPR 1 6143400.0 2585200.0 1342500.0 2215700.0 True False 2149708.3437784924 1335267.686034615 2678992.6257607006 1.0 0.6211389977152184 1.2462121354806195 21.035709508428845 -6.742607882249953 1.6770008693322487 0.7752668242726267 1.2468028181090354 0.6166729023174808 0.1591752177806922 0.31310885635891605 1.7299345890081983 0.07505652025852448 0.1836678649466526 1.8088065323189962e-07 6.742607882249953 0.47153599383640865 AETELK(ub)ASQKPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AETELKASQKPIR 13 2 P11171;P11171-2;A0A2U3TZH6;P11171-5;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A3B3ITC5;A0A2R8Y6T6 P11171 EPB41 Protein 4.1 1 3843420.0 1865600.0 1493700.0 484120.0 True False 2555362.735944319 1427703.394994638 369780.8267643727 1.0 0.5587087010827207 0.14470776362312507 21.285096666828984 -7.806847555892979 0.3986537417417769 1.0512905962634373 3.909722104791089e-18 0.9979948774510334 0.01563806505606843 0.11291942149238292 0.07202668200766921 0.03439445609450479 0.07910530761958422 1.560100026061666e-08 7.806847555892979 -1.0512905962634373 down AETELK(ub)ASQKPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AETELKASQKPIR 13 2 P11171;P11171-2;A0A2U3TZH6;P11171-5;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A3B3ITC5;A0A2R8Y6T6 P11171 EPB41 Protein 4.1 1 5753130.0 2183700.0 2987200.0 582230.0 True False 1815843.3043126608 2971107.3606872223 703971.6010726427 1.0 1.6362135177802999 0.3876830117448446 20.792208281950405 -6.76818637557298 1.5814453203749026 1.3657595730128886 0.38114475907328327 0.7235616235304718 0.2680088985532595 0.26937027423016036 1.3292743167570613 0.1336047433210327 0.31856045704919983 1.7053503883039565e-07 6.76818637557298 -0.9846148139396054 AEVAAEFLNDRVPNCNVVPHFNK(ub)IQDFNDTFYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYR 33 2 F8W8D4;Q8TBC4-2;Q8TBC4 F8W8D4 UBA3 NEDD8-activating enzyme E1 catalytic subunit 1 161221000.0 43882000.0 62944000.0 54395000.0 True False 66572202.20392186 51711151.416283265 43643804.4078246 1.0 0.7767679257159513 0.6555860098203794 25.98841655751084 -13.999999999997 0.07457216952659278 2.2475570069946165 0.25434913562292 0.9999080812915329 0.0013676242477065161 12.313175426863303 0.07521862097395439 2.6031710708572593 0.3670376420577686 1.0000000000069084e-14 13.999999999997 -1.9932078713716965 AEVAAEFLNDRVPNCNVVPHFNK(ub)IQDFNDTFYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYR 33 2 F8W8D4;Q8TBC4-2;Q8TBC4 F8W8D4 UBA3 NEDD8-activating enzyme E1 catalytic subunit 1 171861000.0 43882000.0 57880000.0 70099000.0 True False 56806114.043538675 54658927.11939088 57341701.2764795 1.0 0.9622014820006506 1.0094283378111435 25.759542879603288 -6.693579901140945 1.8537101062462507 0.9763825842921783 1.0092724291496902 0.38721410555024094 0.015974701663963916 0.40902523902860594 2.7277341189539612 0.006887024441452869 0.017853698298799896 2.0249770189483463e-07 6.693579901140945 0.032889844857511896 AEVDPLSDK(ub)GTTPLQLAIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEVDPLSDKGTTPLQLAIIR 20 1 Q9H672-2;Q9H672 Q9H672-2 ASB7 Ankyrin repeat and SOCS box protein 7 1 4533830.0 871430.0 1106700.0 2555700.0 True False 1193621.2205102686 1057802.3346325008 1952096.2962937006 1.0 0.8862127419117886 1.6354403413330627 20.186913658867756 -6.868181219563485 1.1435868705961056 0.9362944463944138 1.6778444338404979 0.9628385915164089 0.06354928602269684 0.13861534219596797 0.33993332457885644 0.04317053585086349 0.1019039839077486 1.354624045733066e-07 6.868181219563485 0.741549987446084 AEVEAIMEQLK(ub)ELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEVEAIMEQLKELK 14 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 10500700.0 1973900.0 5462500.0 3064300.0 True False 1911239.624958232 7643704.736561178 2261667.9029704984 1.0 3.9993440051915115 1.1833513042719197 20.866077239353977 -6.631252831262678 2.075539525156867 2.974142435584343 1.1946437952099471 0.12218393517215664 1.2861362881500498 0.5557197738148255 4.563615579731659 0.5064864390420865 1.4249688949796335 2.3374760445756707e-07 6.631252831262678 -1.7794986403743958 AEVEGK(ub)DLPEHAVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEVEGKDLPEHAVLK 15 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 6950210.0 2837100.0 2634810.0 1478300.0 True False 2747037.8134500226 3686903.373352637 1091088.8819506208 1.0 1.342137831267139 0.3971874273475381 21.389445338821073 -6.8087393696052185 1.4197120645050751 1.1867416088278797 0.3811097340909656 0.8565443577796534 0.1479557149325643 0.2085204305548861 0.8285727571693956 0.08194873289397862 0.18968485807739155 1.553318913735822e-07 6.8087393696052185 -0.8056318747369141 down AEVEGK(ub)DLPEHAVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEVEGKDLPEHAVLK 15 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 7273700.0 2379800.0 2980900.0 1913000.0 True False 3259676.371676827 2849193.9814819046 1461188.7994717103 1.0 0.8740726552606314 0.44826192322891634 21.636297306739582 -6.948734313334574 0.5725749944944102 1.0052444383590127 0.2962959447267035 0.9990981427226956 0.007089584927926338 0.08399810125396615 0.03809741097464722 0.007489108650256764 0.03550110635294594 1.1252931797170166e-07 6.948734313334574 -0.7089484936323092 down AEVEGK(ub)DLPEHAVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEVEGKDLPEHAVLK 15 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 7883900.0 2837100.0 3620200.0 1426600.0 True False 2359174.354840614 3600697.2640465586 1724895.464146869 1.0 1.5262531387977138 0.7311436988994411 21.16985061425535 -6.728237258779848 1.7295410138311706 1.3173221032603097 0.7317598139181648 0.5510658602225156 0.2212578264853652 0.33958326632576635 1.9892012671429549 0.10140946502808336 0.2521556386854587 1.8696604498607646e-07 6.728237258779848 -0.5855622893421449 AEVEQK(ub)LQLLEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEVEQKLQLLEEK 13 1 Q8IX12-2;Q8IX12 Q8IX12-2 CCAR1 Cell division cycle and apoptosis regulator protein 1 1 9872200.0 3855600.0 3981700.0 2034900.0 True False 5054728.937683511 3387645.8805450355 1824348.0681391195 1.0 0.6701933817439341 0.3609190701678228 22.269202298298165 -7.2997816214618885 0.24554850897729735 1.1231407039084846 8.209522685290741e-13 0.9999461184769225 0.0019154591414787248 0.10577304927369588 0.015884381827858514 0.015998114752617327 0.04749688836113035 5.0143931156484814e-08 7.2997816214618885 -1.1231407039076637 down AEVEQK(ub)LQLLEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEVEQKLQLLEEK 13 1 Q8IX12-2;Q8IX12 Q8IX12-2 CCAR1 Cell division cycle and apoptosis regulator protein 1 1 18109200.0 7941100.0 4485200.0 5682900.0 True False 7689014.127238376 6276163.750009007 4194378.006654383 1.0 0.8162507762569535 0.5455027051902239 22.874367199380767 -6.965552237492012 0.34844612374056655 1.026636780671639 0.32600246423377294 0.9999240780605795 0.001626569667855958 0.07777407900594543 0.014202084055052628 0.0037313824044179146 0.023295722548033863 1.0825494968672922e-07 6.965552237492012 -0.7006343164378661 AEVEQK(ub)LQLLEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEVEQKLQLLEEK 13 1 Q8IX12-2;Q8IX12 Q8IX12-2 CCAR1 Cell division cycle and apoptosis regulator protein 1 1 12840300.0 3855600.0 4061400.0 4923300.0 True False 5281119.513672233 3881953.9187462144 3760517.938546304 1.0 0.7350626905329952 0.7120683273330096 22.332412359821056 -13.999999999999998 0.3460991725696979 4.180838657490019 0.7087254718797107 0.9997472055043748 0.0020772657411786037 20.27748683948861 0.18910824817478433 47.330510785791674 0.006953389781113574 1.0000000000000041e-14 13.999999999999998 -3.4721131856103087 AEVEQK(ub)LQLLEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEVEQKLQLLEEK 13 1 Q8IX12-2;Q8IX12 Q8IX12-2 CCAR1 Cell division cycle and apoptosis regulator protein 1 1 15475200.0 7941100.0 4890100.0 2644000.0 True False 6603376.500378845 4863756.060691144 3196848.175525247 1.0 0.7365559211127979 0.48412326259782995 22.654772474815044 -6.971644919121559 0.21530285503694804 1.1235412642987213 0.09004844463334756 0.9999925269313861 0.0005757460211496516 0.07577248191764595 0.007088200432133045 0.007250448236237696 0.025846537169737616 1.0674685310129421e-07 6.971644919121559 -1.0334928196653737 down AEVGEK(ub)TEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEVGEKTEER 10 1 G5E972;P42167;H0YJH7 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 25454000.0 8964600.0 10742000.0 5747400.0 True False 11752677.413309893 9139335.471988045 5152714.180953741 1.0 0.7776385882622592 0.4384289638647189 23.48648612320483 -6.964975929208477 0.35846940711022507 1.029745561942771 0.17472534221037464 0.9999126428227132 0.0021581826411301765 0.07796917999005562 0.014889042376840609 0.004565419557295092 0.028999521570758698 1.0839869923848964e-07 6.964975929208477 -0.8550202197323963 down AEVGEK(ub)TEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEVGEKTEER 10 1 G5E972;P42167;H0YJH7 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 11675070.0 4652800.0 6058100.0 964170.0 True False 4505099.4108139565 8477130.922574144 711624.9525200102 1.0 1.8816745535571973 0.15795987782463555 22.103127510636224 -6.7677003845557655 1.5836231679496262 1.5071972543213161 0.14917701760794508 0.7215542450287591 0.371362733889861 0.27016355064217135 1.3368377475947748 0.184893444875934 0.4409926100716712 1.707259804374082e-07 6.7677003845557655 -1.3580202367133711 AEVGEK(ub)TEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEVGEKTEER 10 1 G5E972;P42167;H0YJH7 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 18985300.0 8964600.0 6260400.0 3760300.0 True False 12279054.87920586 5983794.827625653 2872194.5858094473 1.0 0.4873172150862356 0.2339100699576973 23.549696184727722 -9.500701173623435 0.20306869571849417 1.4953651625745654 2.996430999039993e-16 0.9994661126181182 0.007363177612439245 0.9227173285329994 0.08045023165276798 0.41986132501533796 0.14093629812376215 3.1571762444072684e-10 9.500701173623435 -1.4953651625745652 AEVGEK(ub)TEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEVGEKTEER 10 1 G5E972;P42167;H0YJH7 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 10694140.0 4652800.0 4502900.0 1538440.0 True False 3869009.35398908 4478641.983944327 1860120.6910571354 1.0 1.157568145790781 0.48077441041575353 21.8835327860705 -6.845390779210966 1.257148506341053 1.0838587392165973 0.45603385182390166 0.9333261355919323 0.07466239725134464 0.16259734543000037 0.4968309428343209 0.0465234797243442 0.10738663166093447 1.4276088145926384e-07 6.845390779210966 -0.6278248873926956 down AEVIMNYHVGETVLSLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEVIMNYHVGETVLSLQK 18 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 8535900.0 2216500.0 2337400.0 3982000.0 False True 2146138.420750761 3270736.0093799722 2938994.742560623 1.0 1.5240098111825449 1.36943391635126 21.033311698769257 -10.036069398307918 4.825272347346082 0.9999903841816944 1.4467218636565273 0.917600595042608 0.06310534483944384 6.770272470708845e-06 1.3525939689101391e-06 0.06110285054889655 0.02036716246438431 9.203024997961091e-11 10.036069398307918 0.44673147947483294 AEVIMNYHVGETVLSLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEVIMNYHVGETVLSLQK 18 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 65795800.0 10891000.0 26342000.0 28562800.0 False True 16522443.238751935 21641064.289014585 22917350.06048006 1.0 1.3097980714049224 1.3870436550648535 23.977923703741393 -12.698581184681696 0.21404867181527742 2.7441716821446693e-22 1.4333547051245037 0.9994250149993735 0.004010389575958073 7.258013870950346 0.13812196879049926 3.140254100373492 0.044426853247662296 2.0017913824638625e-13 12.698581184681696 1.4333547051245037 AEVIMNYHVGETVLSLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEVIMNYHVGETVLSLQK 18 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 35192000.0 10891000.0 10415000.0 13886000.0 False True 14098614.193705374 9835396.094479196 11358890.482391953 1.0 0.6976143867296133 0.8056742546698931 23.749050025833842 -10.362080422674067 4.925725822979209 1.0001790017021257 0.7516443206996852 0.8756683750592152 0.04411525635460516 8.678187864458773e-05 1.1238947689109779e-05 0.042745021778729915 0.014238137764554492 4.34429768995917e-11 10.362080422674067 -0.24853468100244047 AEVQK(ub)LQMEAPHIIVGTPGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 AEVQKLQMEAPHIIVGTPGR 20 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 140224600.0 47650800.0 57558800.0 35015000.0 True False 62470660.251003645 48971251.40244514 31391983.68759708 1.0 0.7839080170704354 0.5025076341672368 25.89667544200699 -6.967500185948489 0.3121773097224554 1.0422523653264206 0.2351900964834306 0.9999557967432323 0.0013541843558405107 0.07712247927550892 0.011919341698412559 0.004409206504334277 0.024930844267929145 1.0777047922617484e-07 6.967500185948489 -0.80706226884299 AEVQK(ub)LQMEAPHIIVGTPGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 AEVQKLQMEAPHIIVGTPGR 20 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 198179400.0 79336200.0 60933400.0 57909800.0 True False 76817715.7574403 85264424.38348329 42741486.123238884 1.0 1.1099578208328185 0.5564014199302599 26.194935728908302 -6.855084010959452 1.2103096394927668 1.0590402172682647 0.5320039140655926 0.9473844748376881 0.05488626890141308 0.15194899572529677 0.42577816644744837 0.035433841296329746 0.082308363452099 1.3960982703571308e-07 6.855084010959452 -0.5270363032026721 AEVQK(ub)LQMEAPHIIVGTPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEVQKLQMEAPHIIVGTPGR 20 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 690457000.0 95440000.0 76638000.0 518379000.0 True False 144789457.598612 62961350.124572925 415921163.43641335 1.0 0.43484761369239694 2.8725928692228244 27.109381319918473 -6.845672555429859 1.2558308751167349 0.6991966042055773 2.962184884851631 0.933764291173449 0.2681273240694002 0.16228077315367936 0.494694686590614 0.167240706770762 0.38607513446733094 1.4266828628228378e-07 6.845672555429859 2.2629882806460535 up AEVQK(ub)LQMEAPHIIVGTPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AEVQKLQMEAPHIIVGTPGR 20 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 159614300.0 47650800.0 58219100.0 53744400.0 True False 65268588.474450946 55646787.657181785 41051079.62066254 1.0 0.8525814477965068 0.6289561423062148 25.959885503529883 -6.965069951741385 0.3568506916648888 1.0199765023473588 0.45393506199914563 0.9999145776989695 0.001409819930997796 0.07793723443176111 0.01477634908446682 0.00302025261175276 0.019137038281698715 1.083752340149575e-07 6.965069951741385 -0.5660414403482132 AEVQK(ub)LQMEAPHIIVGTPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AEVQKLQMEAPHIIVGTPGR 20 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 188487600.0 79336200.0 69628800.0 39522600.0 True False 65971565.48958658 69253695.83416532 47786592.92814459 1.0 1.0497506815280413 0.7243513561261111 25.975341004342578 -6.867900049572816 1.1450774678906084 1.0278123976718903 0.7060342087293613 0.9625456861918684 0.027697580734378804 0.13888798174842995 0.3416645796820338 0.018794285878953647 0.044343334596938795 1.3555013374485224e-07 6.867900049572816 -0.32177818894252896 AEVQK(ub)LQMEAPHIIVGTPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AEVQKLQMEAPHIIVGTPGR 20 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 395933100.0 106442000.0 67421100.0 222070000.0 True False 137791267.28550074 63669056.517089985 181655538.6306196 1.0 0.46206887977283045 1.3183385435757184 27.037909217220047 -6.736867583293289 1.6980384317193877 0.6787799945081533 1.318517954110143 0.5908540868451795 0.22603883107425865 0.3235130185762613 1.83027608504645 0.10535995383849282 0.25945082396278374 1.8328731815639405e-07 6.736867583293289 0.6397379596019898 AEVVDEIAAK(ub)LGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AEVVDEIAAKLGLR 14 1 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 4765300.0 1446700.0 1146100.0 2172500.0 True False 1400775.3003835438 1603743.7068325416 1603457.0763970274 1.0 1.144897191143664 1.1446925684354854 20.417794119652932 -10.021290951890046 4.782837887578939 0.9999969818141408 1.1447948797932697 0.9999984950172669 8.353688351505895e-05 57695.733069403854 0.009494149831657346 1.9177192436992287 2.85968952632057e-05 9.521580601168206e-11 10.021290951890046 0.1447978979791289 AEVVDEIAAK(ub)LGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AEVVDEIAAKLGLR 14 1 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 4481400.0 1446700.0 1625700.0 1409000.0 True False 1202995.1496767546 1616942.0314238165 1703615.3855200754 1.0 1.344096883398316 1.4161448497758597 20.198199395087208 -12.419837411627997 0.24555444757204098 4.7575885797100734e-11 1.448470998344046 0.9994193452265078 0.004375699074746795 6.411696295573829 0.14777656654943783 3.2187426509511248 0.03405814465144778 3.803317558251251e-13 12.419837411627997 1.44847099829647 AEWLLAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEWLLAVR 8 0 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 10124600.0 2411700.0 3612300.0 4100600.0 False True 3161762.0549360192 3073358.920635116 3676309.247732707 1.0 0.9720399154759631 1.1627406439372616 21.59229736805123 -6.869646513289923 1.1360323040141036 0.9842216457895895 1.1738309751828473 0.9643255983429915 0.015881753133260082 0.13719065167204475 0.3311454160419239 0.0108523425210175 0.025676441981423017 1.3500612952633916e-07 6.869646513289923 0.1896093293932578 AEWLLAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEWLLAVR 8 0 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 10526100.0 2467100.0 4722400.0 3336600.0 False True 3742771.069169484 3879650.823720391 2677119.5475162696 1.0 1.036571767821557 0.7152773968914745 21.835675376184923 -6.8785968517261145 1.0876330761561541 1.0222703018048123 0.6931147818650317 0.9725341964846487 0.023801496619828312 0.12887847356280105 0.27987968371039534 0.016878713025240438 0.0406742032051234 1.3225227401964081e-07 6.8785968517261145 -0.32915551993978054 AEWLLAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEWLLAVR 8 0 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 9317400.0 2411700.0 2512100.0 4393600.0 False True 3303370.663741912 2401107.1155961906 3355922.1690323665 1.0 0.7268657864983044 1.015908449471706 21.655507429574122 -11.055281557454812 11.899544639396153 1.5849379932943706 0.8713871179850052 0.2088530928741732 0.11800117303001378 0.0408410900182095 0.00018973518476885488 0.002548250387432499 0.038084714831515265 8.804778653296705e-12 11.055281557454812 -0.7135508753093653 AEWLLAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEWLLAVR 8 0 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 12074800.0 2467100.0 6395000.0 3212700.0 False True 3193709.583811449 6039112.628343205 2628021.5650857408 1.0 1.8909398208762564 0.8228743084239355 21.606801698277373 -6.685363880634198 1.8827935636941626 1.56098763180098 0.8267562832809893 0.348741531804019 0.3771702129290214 0.42678036263529495 2.929441294851174 0.16047326117602448 0.4203568679278306 2.0636503685112156e-07 6.685363880634198 -0.7342313485199908 AEYEGDGIPTVFVAVAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AEYEGDGIPTVFVAVAGR 18 0 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 26334900.0 8913200.0 9404800.0 8016900.0 False True 11685291.51555158 8001640.499623262 7187388.091534978 1.0 0.6847617356378431 0.6150799132370394 23.478190390013452 -13.999999999999998 0.2121047530888308 2.8390921117934047 0.5748651081013968 0.9994912968549883 0.00377702734164466 12.796726007597215 0.14595866867519267 9.817719595875126 0.04067555600488173 1.0000000000000041e-14 13.999999999999998 -2.264227003692008 AEYEGDGIPTVFVAVAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AEYEGDGIPTVFVAVAGR 18 0 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 102844000.0 23257000.0 56479000.0 23108000.0 False True 35282569.31444802 46399881.177558854 18540693.67140378 1.0 1.315093602283617 0.525491596322365 25.072452287528883 -6.798430081753739 1.4625122462049385 1.1741962989742933 0.5150315193118219 0.8274896336876735 0.13479404464582187 0.22299911272905323 0.9418665669954969 0.07251580357572483 0.16879403077127259 1.590632743488529e-07 6.798430081753739 -0.6591647796624714 AEYEGDGIPTVFVAVAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AEYEGDGIPTVFVAVAGR 18 0 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 22012200.0 8913200.0 0.0 13099000.0 False True 12208650.910173085 0.0 10005285.98237321 1.0 0.0 0.8195242910939586 23.541400451536344 -9.736858958057525 10.653079811553718 0.9999999992216067 0.4097621455469793 0.408851605618618 0.33456939083271786 0.0 0.0 0.32394541729788773 0.1079818065704897 1.8329095834086871e-10 9.736858958057525 -0.5902378536746273 AEYEGDGIPTVFVAVAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AEYEGDGIPTVFVAVAGR 18 0 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 66490000.0 23257000.0 28814000.0 14419000.0 False True 30106644.96400749 27210475.570458323 11794889.951433796 1.0 0.9038029844570347 0.39177032065627354 24.843578609621332 -6.93842033704606 0.674102497546265 1.0059347326009696 0.2598815032115288 0.9979495402932999 0.012088160381040424 0.08849483661897145 0.057947962543050256 0.011630553963500188 0.04438514355917953 1.1523374145341316e-07 6.93842033704606 -0.7460532293894407 down AFAHITGGGLLENIPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFAHITGGGLLENIPR 16 0 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 48986000.0 11790000.0 19561000.0 17635000.0 False True 15456804.17452242 16642575.048180781 15810299.366864897 1.0 1.0767151385415672 1.0228698758392207 23.881738724860085 -10.560021079714778 4.670811051807573 0.9995613626682799 1.0497925071904004 0.5327485942898645 0.021982236447833214 0.00010129143194720587 9.541367542907019e-06 0.02147131687680954 0.007094736306234451 2.7540950222785913e-11 10.560021079714778 0.05023114452212052 AFAHITGGGLLENIPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFAHITGGGLLENIPR 16 0 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 43492500.0 13893000.0 7228500.0 22371000.0 False True 13451974.319643715 10114877.746129515 16511363.984385658 1.0 0.7519251453936328 1.2274305311655525 23.68131459402884 -6.764909813237115 1.5937095375372652 0.8567886314849955 1.2296197162351963 0.7107922087944449 0.10442901950044796 0.27474438356948827 1.376296184346334 0.05167188899691855 0.12359519260423775 1.718265169688338e-07 6.764909813237115 0.37283108475020077 AFAHITGGGLLENIPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFAHITGGGLLENIPR 16 0 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 66660000.0 10946000.0 35200000.0 20514000.0 False True 16605882.259790547 28918284.981144708 16459398.908394372 1.0 1.74144827289107 0.9911788275320444 23.985191038543373 -10.225887577364523 4.005232117511547 0.999717788462377 1.3663135497570509 0.2411832276217315 0.3062962186756068 41730638.8393538 35514875.9390609 93453.49500657964 0.10485333560026601 5.944460185926123e-11 10.225887577364523 0.36659576129467386 AFAHITGGGLLENIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFAHITGGGLLENIPR 16 0 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 62249000.0 11790000.0 24832000.0 25627000.0 False True 16149081.612769913 23734840.131557137 19574430.404632267 1.0 1.469733121714412 1.2121079621737594 23.944948786382977 -10.096447587104404 4.472718971990513 0.9999720512249326 1.3409205419135317 0.7001410507918036 0.10517503103612222 73185160.64969562 1.4421183916248037 23362.771484618574 0.03600421060444632 8.008522736532066e-11 10.096447587104404 0.3409484906885991 AFAHITGGGLLENIPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFAHITGGGLLENIPR 16 0 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 34639800.0 13893000.0 8595800.0 12151000.0 False True 11552645.06425599 8549492.719267288 14691717.920123799 1.0 0.7400463419169271 1.2717189733094227 23.461719869463117 -6.773749897431277 1.5599974515859594 0.8516113006245162 1.275149310653524 0.7447123629855932 0.10967787132075195 0.26041943339376744 1.2512008607921132 0.05539925527007099 0.13143041244591624 1.683643362600432e-07 6.773749897431277 0.4235380100290079 AFAHITGGGLLENIPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFAHITGGGLLENIPR 16 0 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 49427000.0 10946000.0 22319000.0 16162000.0 False True 14169812.777917469 21076928.030022226 13220681.836124053 1.0 1.4874528238558629 0.9330173971477901 23.756317360635823 -6.674481714091227 1.9211309555136467 1.309922079265946 0.9351895586982999 0.2992339591394716 0.20684611371699377 0.45088853333945944 3.212274629321169 0.08654219167955882 0.22990606570363376 2.1160127777891e-07 6.674481714091227 -0.37473252056764617 AFAVGVQQVLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFAVGVQQVLLK 12 0 O95373 O95373 IPO7 Importin-7 0 16230900.0 4431600.0 5779100.0 6020200.0 False True 5809870.51567545 4916880.806755369 5397287.45383613 1.0 0.8462978294420279 0.9289858421584197 22.470074580032367 -10.148982817268685 4.40413825300613 1.0000199136365655 0.8876418357959744 0.7111377217732016 0.03375723984919276 6.654477715242104e-06 1.2858346356886355e-06 0.03269114501065422 0.010895102310267156 7.096058427509841e-11 10.148982817268685 -0.11237807784059106 AFAVGVQQVLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFAVGVQQVLLK 12 0 O95373 O95373 IPO7 Importin-7 0 15269300.0 4431600.0 4364200.0 6473500.0 False True 6070082.27948695 4171375.2135205246 4944592.625917469 1.0 0.6872024169453423 0.8145841190039671 22.53328464155526 -10.052502328941909 4.932528429548893 1.000005282338939 0.7508932682496643 0.8360420256269268 0.0520033621094542 3.0209354661337434e-06 5.802613148354569e-07 0.050353106733781086 0.016784012948634602 8.861304716950798e-11 10.052502328941909 -0.24911201408927464 AFAVGVQQVLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFAVGVQQVLLK 12 0 O95373 O95373 IPO7 Importin-7 0 17867200.0 3625300.0 8802700.0 5439200.0 False True 4693022.315346621 8312822.00680481 4449321.4109049635 1.0 1.7713152523526483 0.9480716501933663 22.162085889729422 -6.66086831092571 1.969964616477196 1.4961412665834668 0.9515120699974817 0.23920722033036212 0.32834263318290413 0.4824092661207065 3.599830328794461 0.1346214044773056 0.36398344238149516 2.183391871130295e-07 6.66086831092571 -0.5446291965859851 AFAVVASALGIPSLLPFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFAVVASALGIPSLLPFLK 19 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 3640600000.0 1523500000.0 1046200000.0 1070900000.0 False True 2311260882.7691274 859497436.00209 859236145.6078547 1.0 0.37187382973934296 0.3717607787219597 31.106032966684456 AFAVVASALGIPSLLPFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFAVVASALGIPSLLPFLK 19 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 2825220000.0 1523500000.0 570720000.0 731000000.0 False True 1972200782.6746974 538958930.2968005 597965500.6933982 1.0 0.2732779213107627 0.3031970709809971 30.877159288776905 -10.667101387709197 6.653459153596884 1.0043391811651838 0.28823749614588623 0.9986765288292383 0.012214441705005645 0.0007875015971662631 3.940173009153387e-05 0.011846224203255562 0.003942194108892347 2.1522792182474427e-11 10.667101387709197 -0.7161016850192976 AFAYTWFNLQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFAYTWFNLQAR 12 0 A0A590UJ82;Q12857;B1AKN8;B1AKN7;B1AKN5;A0A590UK73;A0A590UK09;B1AKN6;Q12857-4;Q12857-2;Q12857-3;P08651-2;P08651-6;P08651-3;A0A286YEX4;P08651-5;P08651;P08651-4 A0A590UJ82;P08651-4 NFIA;NFIC Nuclear factor 1 A-type;Nuclear factor 1;Nuclear factor 1 C-type 0 39093800.0 8706800.0 10954000.0 19433000.0 False True 13208852.152342794 8999173.116007367 15592059.032213518 1.0 0.6812986482259342 1.180424979580684 23.65500176621842 -6.73421961609632 1.707744707717182 0.8091132140323594 1.1803695528863272 0.5787346957790435 0.13393625055269132 0.3283953315620744 1.8780890368769336 0.062103019718561574 0.15337963183932846 1.8440826588804822e-07 6.73421961609632 0.3712563388539678 AFAYTWFNLQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFAYTWFNLQAR 12 0 A0A590UJ82;Q12857;B1AKN8;B1AKN7;B1AKN5;A0A590UK73;A0A590UK09;B1AKN6;Q12857-4;Q12857-2;Q12857-3;P08651-2;P08651-6;P08651-3;A0A286YEX4;P08651-5;P08651;P08651-4 A0A590UJ82;P08651-4 NFIA;NFIC Nuclear factor 1 A-type;Nuclear factor 1;Nuclear factor 1 C-type 0 34990800.0 8706800.0 10898000.0 15386000.0 False True 11271124.236686619 10291516.719888084 12585905.873691665 1.0 0.9130869737368353 1.1166504431497202 23.42612808831087 -6.790736669535871 1.493834679343622 0.9514703420151366 1.1188459321745439 0.8035597124658042 0.03696397874204436 0.23426098897917516 1.0327898383370175 0.01947766919959029 0.04556886505731817 1.6190614430925675e-07 6.790736669535871 0.16737559015940728 AFDLIVDRPVTLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFDLIVDRPVTLVR 14 1 O96000-2;O96000;H3BPJ9;H3BV16 O96000-2 NDUFB10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 0 6635100.0 1588100.0 2911300.0 2135700.0 False True 2082014.4791822773 2476945.388158517 1914718.2510809985 1.0 1.1896869176103668 0.9196469430092602 20.989548671089185 -6.717952555570282 1.7670197111926962 1.1156584731085544 0.920125620736775 0.5026621495840488 0.07984189950048283 0.35932246776544313 2.1915691891816085 0.03589534819088563 0.09031699633071821 1.9144650590200508e-07 6.717952555570282 -0.19553285237177942 AFDLIVDRPVTLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFDLIVDRPVTLVR 14 1 O96000-2;O96000;H3BPJ9;H3BV16 O96000-2 NDUFB10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 0 8568900.0 2498900.0 2144800.0 3925200.0 False True 2419573.787328702 3001229.824984242 2897072.3665240966 1.0 1.240396073350468 1.197348219631099 21.20632150564159 -10.08108057931214 4.49119879281232 0.9999836641924453 1.218872146502627 0.971805608508514 0.01757421272930556 12210255.465584712 0.04981512483958901 2062.7387162569153 0.006016120457906234 8.296968106861608e-11 10.08108057931214 0.21888848231018176 AFDLIVDRPVTLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFDLIVDRPVTLVR 14 1 O96000-2;O96000;H3BPJ9;H3BV16 O96000-2 NDUFB10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 0 9095100.0 1588100.0 3503800.0 4003200.0 False True 2175263.486788795 3348990.5304828365 3057726.6084919767 1.0 1.5395792513516333 1.405681025339099 21.052758732612077 -9.99197313220928 4.591752499331624 0.9999893437804516 1.4726301381260065 0.9432217627019567 0.054663722004063026 8618774.1400484 9377525.539912421 770.9667096634531 0.018712848255622645 1.0186544055409736e-10 9.99197313220928 0.47264079434555495 AFDLIVDRPVTLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFDLIVDRPVTLVR 14 1 O96000-2;O96000;H3BPJ9;H3BV16 O96000-2 NDUFB10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 0 5145200.0 2498900.0 1505600.0 1140700.0 False True 2077946.0700402556 1497489.0339617971 1379215.0959991117 1.0 0.7206582767245671 0.6637396012748263 20.986726781075866 -13.999999999999998 0.2236229282843063 2.7129413474131305 0.6343308391339507 0.9995017788049704 0.00327999487548782 13.100789774744742 0.14977975281030684 9.929021685895203 0.03076440884599831 1.0000000000000041e-14 13.999999999999998 -2.07861050827918 AFDSAVAK(ub)ALEHHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFDSAVAKALEHHR 14 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 20237700.0 7645700.0 4717900.0 7874100.0 True False 10023586.741064113 4014007.710230161 7059363.6657006405 1.0 0.40045622529366476 0.7042752108664061 23.256895504843122 -10.542476236032318 6.452462904636656 1.000499767746264 0.552365718080067 0.7432197373961512 0.12403358147053672 0.0008926793367558091 6.329698694020932e-05 0.12022242816323858 0.04003166628382078 2.867634284100511e-11 10.542476236032318 -0.44813404966619697 AFDSAVAK(ub)ALEHHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFDSAVAKALEHHR 14 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 18912300.0 5035000.0 5794400.0 8082900.0 True False 4875166.681019654 8108134.137396808 5965746.008197712 1.0 1.6631501378125129 1.2237009313802498 22.217020114498137 -10.244833087989878 4.11897350341618 0.9996577472562693 1.4434255343766231 0.5758347380559193 0.1794043873766226 24870830.887603384 30930025.63829925 62606.01367193827 0.0614148916990593 5.690715996000882e-11 10.244833087989878 0.4437677871203538 AFDSAVAK(ub)ALEHHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFDSAVAKALEHHR 14 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 17842300.0 7645700.0 4593100.0 5603500.0 True False 10472521.907273516 4390161.654649442 4280068.707705033 1.0 0.4192076840250225 0.40869513051411066 23.320105566366014 AFDSAVAK(ub)ALEHHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFDSAVAKALEHHR 14 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 21831600.0 5035000.0 8259100.0 8537500.0 True False 4186825.5883199354 8214606.588997011 10322651.777060065 1.0 1.9620130850239978 2.465507950906137 21.997425389932413 -9.357413605943544 0.1864280111949232 1.1183724733672974e-15 3.0323911794485223 0.9995959191883157 0.012221343891942401 0.7923576423860763 0.07091589604067638 0.7605952084161247 0.3127008875360348 4.3912321158684877e-10 9.357413605943544 3.032391179448521 AFDSAVAK(ub)ALEHHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFDSAVAKALEHHR 14 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 21395600.0 8178100.0 6805300.0 6412200.0 True False 10586711.664451556 6426579.072660527 5245245.394728055 1.0 0.6070420425484834 0.4954555825243385 23.335751208018777 -13.999999999999488 0.17657242963132688 3.018093089089426 0.40360788597196273 0.9995026746239833 0.004825727444331411 12.162323360278787 0.1331718052878678 8.414781113387672 0.08580647971032343 1.000000000001178e-14 13.999999999999488 -2.6144852031174635 AFEK(ub)AAESTSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFEKAAESTSSR 12 1 O75419-2;O75419;O75419-3;A0A5F9ZI22;A0A5K1VW85 O75419-2 CDC45 Cell division control protein 45 homolog 1 5329270.0 837970.0 457000.0 4034300.0 True False 811369.1010315868 639482.483223516 2977595.803594253 1.0 0.788152374068064 3.669841259432351 19.62999883658501 -6.889210631436028 1.0270801909150105 0.8422197449805368 3.9138579776732025 0.9803868018742801 0.18365265974067188 0.11978436320074702 0.2256269110186798 0.136387516368696 0.33905185533001914 1.290593188228624e-07 6.889210631436028 3.0716382326926657 up AFEK(ub)AAESTSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFEKAAESTSSR 12 1 O75419-2;O75419;O75419-3;A0A5F9ZI22;A0A5K1VW85 O75419-2 CDC45 Cell division control protein 45 homolog 1 4671150.0 837970.0 953180.0 2880000.0 True False 696809.1833653339 948045.0301485828 3482194.68438454 1.0 1.3605518595060293 4.997343272037276 19.410404112019286 -6.926055191457617 0.778489228555989 0.9358647519269802 5.674111933907872 0.9957045061044498 0.11832550421835573 0.09473866613288216 0.08809810881537071 0.10536979822047322 0.3364868129349112 1.1856180666593803e-07 6.926055191457617 4.738247181980892 up AFEK(ub)NIFNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFEKNIFNK 9 1 F8VVA7;P61923;P61923-4;P61923-3;P61923-5;F8VXB1;F8VUC5;F8W156;F8VXR1;F8VYZ4;F8VYE0 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 7480800.0 2460500.0 3360600.0 1659700.0 True False 3225739.3275158918 2859211.579516198 1487970.164966583 1.0 0.8863740337375764 0.46128034967799253 21.621198428123098 -6.946413253852832 0.5969270152992499 1.0048222600647763 0.3211860741115177 0.9988888788559817 0.007728721974574731 0.08495883752939648 0.0421756509067501 0.007956534797080254 0.035688455013609476 1.1313233377268713e-07 6.946413253852832 -0.6836361859532585 down AFEK(ub)NIFNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFEKNIFNK 9 1 F8VVA7;P61923;P61923-4;P61923-3;P61923-5;F8VXB1;F8VUC5;F8W156;F8VXR1;F8VYZ4;F8VYE0 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 5672700.0 2460500.0 1995300.0 1216900.0 True False 3370213.3425123254 1907141.0484252525 929493.2828421973 1.0 0.5658814011470189 0.275796570833497 21.68440848964599 -8.274258544517647 0.23076145248522298 1.234254379275545 7.809651807884798e-12 0.9996021844364107 0.005935674085188564 0.09357129441164384 0.05166166658595868 0.10544412721750199 0.10964740865542019 5.317915784503149e-09 8.274258544517647 -1.2342543792677352 down AFEK(ub)NIFNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFEKNIFNK 9 1 F8VVA7;P61923;P61923-4;P61923-3;P61923-5;F8VXB1;F8VUC5;F8W156;F8VXR1;F8VYZ4;F8VYE0 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 11751800.0 3116900.0 7482000.0 1152900.0 True False 2591840.4520823103 7441692.980939272 1393966.0595926857 1.0 2.8712002604020403 0.5378286531768418 21.305545481190947 -6.6931939328623224 1.8548043404446481 2.169621580910995 0.54553044213788 0.38539798832157957 0.7908868659504665 0.40991639930542717 2.736546739282506 0.3407797915783425 0.8839439747116478 2.026777466186638e-07 6.6931939328623224 -1.6240911387731152 AFEK(ub)NIFNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFEKNIFNK 9 1 F8VVA7;P61923;P61923-4;P61923-3;P61923-5;F8VXB1;F8VUC5;F8W156;F8VXR1;F8VYZ4;F8VYE0 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 7898200.0 1234200.0 3840800.0 2823200.0 True False 1597696.22971914 3627056.1036654566 2309406.568478249 1.0 2.2701787963179076 1.4454603606871006 20.60756170378706 -10.228241385821203 4.731565250456137 0.9998234895623392 1.8578195785001632 0.5905853209488503 0.33668989157891954 0.0006796628751585568 0.00011085952117194518 0.326069844746798 0.1086661952256854 5.912329288367532e-11 10.228241385821203 0.857996088937824 AFELLHLHLDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFELLHLHLDLR 12 0 A6NKB8;Q9H4A4;A0A087WU27 A6NKB8 RNPEP Aminopeptidase B 0 262471000.0 46121000.0 101050000.0 115300000.0 False True 69968928.89674757 83016837.99274644 92510904.46221475 1.0 1.1864814754453872 1.3221712254411118 26.06021107086809 -6.97458743471818 0.09959561866668042 0.6624644823922462 1.849629096816653 0.9999997476159662 6.609722280699523e-05 0.0748404714809493 0.0029227738870754387 0.01231074523974075 0.022308538478016463 1.0602604590150409e-07 6.97458743471818 1.187164614424407 AFELLHLHLDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFELLHLHLDLR 12 0 A6NKB8;Q9H4A4;A0A087WU27 A6NKB8 RNPEP Aminopeptidase B 0 180466000.0 46121000.0 60940000.0 73405000.0 False True 59704543.680826865 57548635.42943475 60046043.19890403 1.0 0.9638903822309179 1.0057198246066963 25.83133739296054 -6.678277957445899 1.9075534592913321 0.977118836853139 1.0055604163785832 0.31650414375591407 0.015309724510168599 0.4423332054276707 3.110258662838055 0.006442901424061683 0.017033097882926684 2.0975969485089089e-07 6.678277957445899 0.028441579525444127 AFFSEVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFFSEVER 8 0 Q9UQ80;Q9UQ80-2;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 7133800.0 2437200.0 1048600.0 3648000.0 False True 2359832.420055832 1467311.4483767617 2692479.362345845 1.0 0.621786291224038 1.140962103691305 21.170252981733938 -6.7113093711049805 1.7900838804283217 0.7678075839630291 1.139817503219455 0.4715972078869676 0.15934336784539319 0.37241235205932494 2.326950161803973 0.0708087401915422 0.17963297407891282 1.943974791426067e-07 6.7113093711049805 0.372009919256426 AFFTSK(ub)ALNMAIPGGPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFFTSKALNMAIPGGPK 17 1 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 3748010.0 838810.0 1438600.0 1470600.0 True False 1099688.0330475946 1223966.4876188785 1318436.418991297 1.0 1.1130124642957764 1.1989185836072793 20.06866287761136 -6.974165191652963 0.12313281615525788 0.8525947345839582 1.4615484977599675 0.9999993781214794 6.397808686337241e-05 0.07497296298776192 0.003675855337238156 0.005837040875080023 0.01216819784576115 1.0612917991486e-07 6.974165191652963 0.6089537631760094 AFFTSK(ub)ALNMAIPGGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFFTSKALNMAIPGGPK 17 1 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 7714900.0 2133800.0 2296200.0 3284900.0 True False 2066063.6869830678 3213084.6345248143 2424486.145112356 1.0 1.5551721153459035 1.1734808372014265 20.97845329568518 -10.588636019122193 5.787642335980217 0.9984841316341501 1.3643264762733782 0.5484868009046159 0.1558248117874498 0.003059347254917887 0.0002174470254382256 0.15144251656146174 0.05029224174822483 2.5784812689545804e-11 10.588636019122193 0.36584234463922816 AFFTSK(ub)ALNMAIPGGPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFFTSKALNMAIPGGPK 17 1 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 9223700.0 2630100.0 0.0 6593600.0 True False 3990053.986065698 0.0 5290372.069922461 1.0 0.0 1.3258898472045269 21.92797683579745 -6.704940831092867 1.8130841474838209 0.38206507760147157 1.3223545978379947 0.4410915709183304 0.4217449018248032 0.3853474644560814 2.4659600809250373 0.18532997052105257 0.47376366795535846 1.9726914801423007e-07 6.704940831092867 0.9402895202365231 AFFTSK(ub)ALNMAIPGGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFFTSKALNMAIPGGPK 17 1 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 6011000.0 2133800.0 1578000.0 2299200.0 True False 1774349.2433678424 1569499.0007915236 2779952.089700323 1.0 0.8845490856199774 1.566744596697195 20.758858571119458 -6.8633440571504885 1.1686264153347414 0.9367062647393664 1.6019688178000868 0.9575826130248432 0.06140075670917309 0.14340209119523614 0.3702428610289119 0.040917999027044606 0.09591018009471115 1.369796155103727e-07 6.8633440571504885 0.6652625530607205 AFFTSK(ub)ALNMAIPGGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFFTSKALNMAIPGGPK 17 1 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 12692500.0 2630100.0 3611600.0 6450800.0 True False 3404716.2970218114 3410611.2851484474 5276820.590797493 1.0 1.0017314183069503 1.5498561790341407 21.699103157889898 -6.907592315135723 0.9119770489272202 0.9817095756961352 1.6171612153661987 0.9899806681364376 0.025904757947601803 0.10603195342889657 0.14756424106037713 0.02095921989119356 0.056935646388239815 1.2371081979918686e-07 6.907592315135723 0.6354516396700636 AFGFSHLEALLDDSK(ub)ELQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFGFSHLEALLDDSKELQR 19 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 38581500.0 3758300.0 9871800.0 24951400.0 True False 5701615.868533785 8110100.161274558 20019744.853412855 1.0 1.4224213535732517 3.5112405526823203 22.442939414066664 -6.940052800152296 0.6590712407111262 0.976574887948428 4.075406285553547 0.9981708191739208 0.04695486437963043 0.08774253597477807 0.05449984684622954 0.04572535971408739 0.1797386842319199 1.1480140410886754e-07 6.940052800152296 3.098831397605119 up AFGFSHLEALLDDSK(ub)ELQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFGFSHLEALLDDSKELQR 19 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 10779200.0 5087400.0 3100200.0 2591600.0 True False 4230398.510033538 3083498.6072584796 3133491.5777954734 1.0 0.7288908125192287 0.7407083683401334 22.012362143158455 -10.319226795438986 14.788774072681335 0.9999999119703857 0.7347995904301091 0.998512960394652 0.004824496961613464 6.745445425528504e-12 0.0 0.004671299096418298 0.001557099698806099 4.7948298965398725e-11 10.319226795438986 -0.2652003215402766 AFGFSHLEALLDDSK(ub)ELQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFGFSHLEALLDDSKELQR 19 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 41780000.0 3758300.0 7158500.0 30863200.0 True False 4865193.437168576 6760123.1821727725 25246414.283174407 1.0 1.389487030572622 5.18919023656893 22.214065736159114 -6.926602652207609 0.7741686744361104 0.9343599120143284 5.905798290931615 0.9958273637374999 0.12206708208894565 0.09444084000320146 0.086606014386424 0.10903832999660182 0.35044992521207685 1.1841244478171802e-07 6.926602652207609 4.971438378917286 up AFGQAK(ub)HQPTAIIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFGQAKHQPTAIIAK 15 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 4349600.0 1939500.0 2410100.0 0.0 True False 2542703.282144715 2050522.4744962181 0.0 1.0 0.8064340377012638 0.0 21.27793168752437 -7.240769285185454 0.8599961304569199 0.9894574979541514 1.7993732066909053e-16 0.9889229506154621 0.045577630920691274 0.09736178572172052 0.13846503101356913 0.03858182131925428 0.06788948460944934 5.7442153714648704e-08 7.240769285185454 -0.9894574979541512 down AFGQAK(ub)HQPTAIIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFGQAKHQPTAIIAK 15 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 11042700.0 2769100.0 2844600.0 5429000.0 True False 2681196.4362287065 3980463.6143930326 4006982.033491116 1.0 1.4845848519744558 1.494475369036079 21.354445490692868 -11.495923403679454 0.6191063323217032 1.777172158353586e-07 1.493151262629194 0.9999612128380673 0.0014374082132210541 4.695782404093338 0.30941882791341746 6.344674088449191 0.0016803634288396908 3.1921007948241384e-12 11.495923403679454 1.4931510849119782 AFGQAK(ub)HQPTAIIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFGQAKHQPTAIIAK 15 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 25346300.0 5671700.0 7416600.0 12258000.0 True False 8604383.556811066 6093049.783839707 9835200.927127732 1.0 0.7081332141471732 1.143045386364997 23.036640406402164 -6.7258280791875755 1.737947892682446 0.8235532817473483 1.1426204387591483 0.5400777581517834 0.12273893041098358 0.34409696165819287 2.034045464158734 0.056005512228556036 0.13966130152946232 1.8800609147509867e-07 6.7258280791875755 0.3190671570118 AFGQAK(ub)HQPTAIIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFGQAKHQPTAIIAK 15 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 7222300.0 1939500.0 1922300.0 3360500.0 True False 2656585.563016726 1837366.4298039745 2566819.1116699893 1.0 0.6916270476594494 0.9662098399553142 21.34114174904726 -10.27397981531697 7.566417866296956 1.0000005493273374 0.8289184442554166 0.341067021736302 0.11209795554558077 1.0388328157121828e-06 9.960974600976286e-08 0.10853872808108453 0.036179459580994486 5.3213299061060277e-11 10.27397981531697 -0.1710821050719208 AFGQAK(ub)HQPTAIIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFGQAKHQPTAIIAK 15 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 9445400.0 2769100.0 4598600.0 2077700.0 True False 2302629.34192984 4573826.429049364 2512137.463800608 1.0 1.986349407506476 1.090986472749096 21.134850766127144 -6.623137388947151 2.10586551075893 1.6530601530262086 1.094510761903637 0.09317539345136294 0.4238345851705796 0.5770939676908732 4.867660043087741 0.1651520645375951 0.4696395324713788 2.38156594240534e-07 6.623137388947151 -0.5585493911225716 AFGQAK(ub)HQPTAIIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFGQAKHQPTAIIAK 15 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 21618600.0 5671700.0 5668900.0 10278000.0 True False 7342127.455921289 5353420.731636406 8407509.461185697 1.0 0.7291375372840977 1.1451053542260694 22.807766728494613 -6.730963137306917 1.719546013164287 0.8371714357339941 1.1449090956013945 0.5637755875677162 0.11385603461619538 0.33444875872751934 1.9377714495412262 0.05245967078151109 0.13004197235833206 1.8579621512743626e-07 6.730963137306917 0.3077376598674004 AFHAALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFHAALR 7 0 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 0 9115700.0 2943800.0 2842700.0 3329200.0 False True 3859350.3077997537 2418580.2407578146 2984726.3199414 1.0 0.6266806710626552 0.7733753305340701 21.879926570546733 -10.219139462062273 4.980388457379573 1.0000387339073955 0.70002800079805 0.8479166701873389 0.05988784395046978 2.5760370631506396e-05 4.0389112215014566e-06 0.05799363166031017 0.019328718521547862 6.03754718556547e-11 10.219139462062273 -0.30001073310934545 AFHAALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFHAALR 7 0 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 0 5309500.0 1742700.0 1933600.0 1633200.0 False True 1449132.2647001315 1923183.3130104525 1974694.568936398 1.0 1.3271275230411188 1.3626737993753946 20.46675784739264 -12.258871545966427 0.3447005482655582 2.7941810598667327e-07 1.3683135245518534 0.9996316641567279 0.0031327955210304435 6.308898866314163 0.18338201278772384 4.5059134095267845 0.010798361830790287 5.509706363871628e-13 12.258871545966427 1.3683132451337474 AFHPFIAGPYNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFHPFIAGPYNR 12 0 A0A024R4E5;Q00341;Q00341-2;H0Y394;H7C0A4 A0A024R4E5 HDLBP Vigilin 0 4458900.0 1585600.0 1308200.0 1565100.0 False True 2171839.1692288322 1250399.3983611083 1195455.6142463016 1.0 0.5757329622179597 0.550434687422448 21.050485840814975 -13.999999999999998 0.40125190383311676 8.209549735865352 0.5489932821020662 0.9998395308600408 0.002612353192903435 26.956752914106517 0.20892145832333425 169.28284748343413 0.006451107944048596 1.0000000000000041e-14 13.999999999999998 -7.660556453763285 AFHSSLHESIQK(ub)PYNQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFHSSLHESIQKPYNQK 17 1 P23634-7;P23634-6;P23634-8;P23634 P23634-7 ATP2B4 Plasma membrane calcium-transporting ATPase 4 1 6520120.0 3043800.0 2541200.0 935120.0 True False 3990451.2762011318 2162062.8655200163 838362.7527044343 1.0 0.5418091127723974 0.2100922163125738 21.928120477957894 -8.102073447099505 0.2921704397436836 1.1412809135866764 3.057517380639019e-14 0.9991787278970021 0.009280939234379731 0.09131246525183928 0.06088007202850838 0.07020434486156311 0.09378228426263693 7.905449211627396e-09 8.102073447099505 -1.1412809135866457 down AFHSSLHESIQK(ub)PYNQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFHSSLHESIQKPYNQK 17 1 P23634-7;P23634-6;P23634-8;P23634 P23634-7 ATP2B4 Plasma membrane calcium-transporting ATPase 4 1 5970300.0 3043800.0 1703200.0 1223300.0 True False 4169175.115602126 1627946.9922707847 934381.7346543359 1.0 0.390472203045295 0.22411669185053873 21.991330539480785 -13.999999999999998 0.18222366664074985 4.18449365958012 0.09496178439937887 0.9994956247793985 0.007490562513203024 12.23430872617976 0.13534072693864543 13.80163076074704 0.12189892052972533 1.0000000000000041e-14 13.999999999999998 -4.089531875180741 AFIAVYYLLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFIAVYYLLPK 11 0 O95273;O95273-2;H3BR23 O95273 CCNDBP1 Cyclin-D1-binding protein 1 0 13541900.0 3899200.0 4399400.0 5243300.0 False True 5915371.469703572 3614292.697330909 4206959.45677997 1.0 0.6110001232960652 0.7111910855178782 22.496037338171863 -9.98951377146895 6.911418365680743 1.0000000351709528 0.6610956044069736 0.9384836346564899 0.04090278904698709 2.215367001027574e-08 3.24470469027582e-09 0.03960395932910509 0.013201318399367657 1.024439294846686e-10 9.98951377146895 -0.33890443076397925 AFIAVYYLLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFIAVYYLLPK 11 0 O95273;O95273-2;H3BR23 O95273 CCNDBP1 Cyclin-D1-binding protein 1 0 9348500.0 3899200.0 3490100.0 1959200.0 False True 5047591.264722802 3295872.866955529 1602645.7030896114 1.0 0.6529595393331691 0.3175070284098417 22.267163660264313 -7.392639214492869 0.2748517559868056 1.1014726210501566 9.250983392225471e-18 0.9998634985338846 0.0032554527680947543 0.11643464134548483 0.022678259599880738 0.018784885479015436 0.05626390455155234 4.049121284460518e-08 7.392639214492869 -1.1014726210501566 down AFIGFEGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFIGFEGVK 9 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 8190300.0 2032300.0 2226600.0 3931400.0 False True 2664364.9808211927 1894399.9592188208 3524616.440651696 1.0 0.711013683506282 1.3228729794989884 21.34536029435861 -6.778233293362085 1.5424686537908545 0.8359992377058036 1.327480801003005 0.7612208392563053 0.12212260286137401 0.2533084214889914 1.1902282935735828 0.062363358458814806 0.1473876526492606 1.6663518448390065e-07 6.778233293362085 0.4914815632972014 AFIGFEGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFIGFEGVK 9 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 7598000.0 2032300.0 2635000.0 2930700.0 False True 2783696.230842429 2518576.9872202384 2238529.019661132 1.0 0.9047599947563395 0.8041570753514604 21.4085703558815 -6.970432068275581 0.24764901964172978 1.0328643526160879 0.6731149625165782 0.9999855540530366 0.0003038653381461886 0.07616276545516244 0.00852701421089986 0.0022800444351994908 0.00967932072189035 1.0704538086772075e-07 6.970432068275581 -0.3597493900995097 AFIGIGFGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFIGIGFGDR 10 0 F6SKB8;Q9NVZ3-3;Q9NVZ3-4;Q9NVZ3;Q9NVZ3-2 F6SKB8 NECAP2 Adaptin ear-binding coat-associated protein 2 0 15744500.0 4127600.0 5617600.0 5999300.0 False True 5411323.571735258 4779475.977233291 5378549.985349167 1.0 0.8832360353015534 0.9939435175236468 22.36755007961162 -10.548036889380866 5.986200343835468 1.0001209745121904 0.9385897764164414 0.29091420329200945 0.045196140358728175 7.311507090686033e-05 5.5202909411600015e-06 0.04384706869376873 0.01458699157685059 2.831151504919982e-11 10.548036889380866 -0.06153119809574903 AFIGIGFGDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFIGIGFGDR 10 0 F6SKB8;Q9NVZ3-3;Q9NVZ3-4;Q9NVZ3;Q9NVZ3-2 F6SKB8 NECAP2 Adaptin ear-binding coat-associated protein 2 0 18235500.0 6736200.0 4759100.0 6740200.0 False True 6522363.018209464 6659433.448378645 4974739.418334283 1.0 1.0210154555621178 0.7627204135135615 22.63696330939793 -6.88718095880679 1.038890423525568 1.0148307937808503 0.7416919656821066 0.9790326641542277 0.016959488296303046 0.12146121206341588 0.23543485797562286 0.012481959830757927 0.030818783228316392 1.296638883929651e-07 6.88718095880679 -0.2731388280987437 AFIGIGFGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFIGIGFGDR 10 0 F6SKB8;Q9NVZ3-3;Q9NVZ3-4;Q9NVZ3;Q9NVZ3-2 F6SKB8 NECAP2 Adaptin ear-binding coat-associated protein 2 0 19744600.0 4127600.0 6758700.0 8858300.0 False True 5653685.264195847 6460078.285967907 6766151.982415196 1.0 1.142631395999147 1.1967684202841065 22.43076014113451 -13.999999999998776 0.13431383546740885 0.32130002355326026 1.268588024890893 0.9996265391771665 0.0016038638005394501 11.932488742902025 0.11437420900053237 2.130444563819594 0.063992080251523 1.0000000000028181e-14 13.999999999998776 0.9472880013376327 AFIGIGFGDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFIGIGFGDR 10 0 F6SKB8;Q9NVZ3-3;Q9NVZ3-4;Q9NVZ3;Q9NVZ3-2 F6SKB8 NECAP2 Adaptin ear-binding coat-associated protein 2 0 14596300.0 6736200.0 2731600.0 5128500.0 False True 5601448.764258351 2716884.328619854 6200845.638495167 1.0 0.48503243410092634 1.1070074724348884 22.417368584832207 -6.686870578070946 1.8776495902576624 0.6761999778129458 1.1047724703235744 0.35573545842488674 0.2179363803706986 0.4234485796850951 2.891981814858055 0.09294138121666334 0.24297467924449326 2.0565033529683355e-07 6.686870578070946 0.42857249251062857 AFIISFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFIISFK 7 0 Q9HAB8;Q9HAB8-2 Q9HAB8 PPCS Phosphopantothenate--cysteine ligase 0 10841300.0 3271300.0 3514100.0 4055900.0 False True 4288705.97931426 2989809.977854511 3636234.3749400275 1.0 0.6971356843475114 0.8478628268010671 22.032110981887705 -10.185111971248425 4.829732836041399 1.0000263809785206 0.772499255573536 0.7523241948468974 0.06153409823576413 1.7481619527023633e-05 2.9495629554383485e-06 0.059587037884618124 0.019860044807214358 6.529621820609835e-11 10.185111971248425 -0.22752712540498454 AFIISFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFIISFK 7 0 Q9HAB8;Q9HAB8-2 Q9HAB8 PPCS Phosphopantothenate--cysteine ligase 0 8349400.0 3015200.0 2042300.0 3291900.0 False True 2919484.1264370326 2857801.0404538005 2429652.635116853 1.0 0.9788719228083248 0.8322198477174202 21.477282036380984 -6.93283934358627 0.723138726159821 1.0020123284551279 0.7998173166699368 0.9970668818294306 0.0040408870345006705 0.09119071587822991 0.07066107143803098 0.003745651549660954 0.013068557699955222 1.1672413290280846e-07 6.93283934358627 -0.20219501178519106 AFIISFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFIISFK 7 0 Q9HAB8;Q9HAB8-2 Q9HAB8 PPCS Phosphopantothenate--cysteine ligase 0 12116400.0 3508500.0 4034000.0 4573900.0 False True 5322651.005707573 3314101.1822141395 3669866.66018841 1.0 0.622641082171341 0.6894809853685967 22.343713544409468 -10.710073478576673 6.808551841592418 1.0036517549739734 0.6560610337699756 0.9724551923661472 0.02728727621504975 0.001523646559079561 6.488087605744839e-05 0.02661409042597591 0.00880693052868745 1.949514732139529e-11 10.710073478576673 -0.3475907212039978 AFIISFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFIISFK 7 0 Q9HAB8;Q9HAB8-2 Q9HAB8 PPCS Phosphopantothenate--cysteine ligase 0 10942300.0 3271300.0 3232000.0 4439000.0 False True 4480788.013558452 3089199.553205242 3390599.6240747133 1.0 0.6894322034110091 0.7566971733130581 22.095321043410596 -10.086937804541503 5.046577406735711 1.0000068318622146 0.7230646883610778 0.9576279637254292 0.027460808973936865 2.110875725691565e-06 3.8188898955593157e-07 0.026589469909640794 0.008862937985310708 8.185820091451955e-11 10.086937804541503 -0.2769421435011368 AFIISFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFIISFK 7 0 Q9HAB8;Q9HAB8-2 Q9HAB8 PPCS Phosphopantothenate--cysteine ligase 0 7086000.0 3015200.0 1546900.0 2523900.0 False True 2507272.396008395 1538566.5426643905 3051635.8208049093 1.0 0.6136415592951947 1.217113794920387 21.25768731181526 -6.733860711346002 1.7099523105909655 0.7684855950928897 1.2169610462732425 0.5767303662188048 0.16237156188455726 0.32904287713465297 1.8866759676883238 0.07520984461972204 0.18576106048141167 1.8456072547676334e-07 6.733860711346002 0.4484754511803528 AFIISFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFIISFK 7 0 Q9HAB8;Q9HAB8-2 Q9HAB8 PPCS Phosphopantothenate--cysteine ligase 0 16471400.0 3508500.0 9258600.0 3704300.0 False True 4541822.412874421 8743350.771036489 3030155.409327704 1.0 1.9250754380559347 0.6671673028734701 22.114839866501917 -6.7096196517251 1.79640763316344 1.5689298555922762 0.6701351719746725 0.4633684221305274 0.38984424782878097 0.3758387796489055 2.3639991067100183 0.17270697229955678 0.43898449232977255 1.9515529909653015e-07 6.7096196517251 -0.8987946836176036 AFIITGQTYTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFIITGQTYTR 11 0 P30566;A0A0A6YY92;A0A1B0GTJ7;A0A1B0GWJ0;A0A096LNY6;P30566-2;A0A1B0GWF8;A0A1B0GTG9;A0A096LNY5;A0A096LPA2;A0A096LP92 P30566 ADSL Adenylosuccinate lyase 0 24824400.0 5958400.0 8246000.0 10620000.0 False True 7811520.101227687 7015728.9426562525 9521144.274233347 1.0 0.8981259539425156 1.2188593450251723 22.897171889664392 -6.821284860731937 1.366367635013994 0.9451611514266842 1.2260526345627645 0.8873002621701596 0.044921285198803645 0.19181713016822416 0.7033334955748792 0.025833222876743812 0.059520171862835855 1.5090899930833732e-07 6.821284860731937 0.28089148313608026 AFIITGQTYTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFIITGQTYTR 11 0 P30566;A0A0A6YY92;A0A1B0GTJ7;A0A1B0GWJ0;A0A096LNY6;P30566-2;A0A1B0GWF8;A0A1B0GTG9;A0A096LNY5;A0A096LPA2;A0A096LP92 P30566 ADSL Adenylosuccinate lyase 0 12731300.0 5958400.0 0.0 6772900.0 False True 8161381.499705538 0.0 5173280.512254025 1.0 0.0 0.6338731393013152 22.960381951187284 -10.230970371925801 7.218826753106779 1.000001918533477 0.3169365696506577 0.6075820710977311 0.25877762549072403 7.990664143890296e-06 8.508131669760205e-07 0.2505610638752036 0.0835201194913895 5.875294331032155e-11 10.230970371925801 -0.6830653488828193 AFIITLNSFGTELSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFIITLNSFGTELSK 15 0 Q8N8Y2 Q8N8Y2 ATP6V0D2 V-type proton ATPase subunit d 2 0 9096900.0 4798100.0 2006500.0 2292300.0 False True 4645786.941847149 2807705.913759268 1691877.8624740634 1.0 0.6043552898366307 0.36417465623194906 22.147491562259383 -8.830622167485766 0.1637497665962957 1.4408449860041013 2.8086493106390692e-11 0.9998139999295451 0.003575221470966501 0.34390462193229765 0.04891762987094982 0.23030440229286628 0.15470444723534732 1.4769909440705969e-09 8.830622167485766 -1.4408449859760148 AFIITLNSFGTELSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFIITLNSFGTELSK 15 0 Q8N8Y2 Q8N8Y2 ATP6V0D2 V-type proton ATPase subunit d 2 0 63222000.0 18384000.0 26738000.0 18100000.0 False True 27889872.050428383 21966394.9950525 14522527.06648817 1.0 0.7876118956492345 0.5207097056676926 24.733237979981997 -6.96803140802188 0.30152240924507573 1.0454602160212538 0.2544800596550548 0.9999626983071895 0.0011976132794234353 0.07694678372009493 0.011304335252068637 0.004394895309629667 0.02389893892452538 1.076387366864862e-07 6.96803140802188 -0.790980156366199 AFIITLNSFGTELSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFIITLNSFGTELSK 15 0 Q8N8Y2 Q8N8Y2 ATP6V0D2 V-type proton ATPase subunit d 2 0 2956580.0 883860.0 540320.0 1532400.0 False True 1210646.9274183905 516446.87580069894 1170478.6807686617 1.0 0.42658752449153886 0.9668208412048057 20.207346748697905 -10.711564203333939 9.927537795161491 1.0004153451542281 0.6967041828481726 0.2958991504546511 0.22054932799981386 0.0020300827956276583 5.898231363751811e-05 0.2138191385288145 0.07118198953004298 1.9428344543086486e-11 10.711564203333939 -0.30371116230605555 AFIITLNSFGTELSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFIITLNSFGTELSK 15 0 Q8N8Y2 Q8N8Y2 ATP6V0D2 V-type proton ATPase subunit d 2 0 9983800.0 4798100.0 2095200.0 3090500.0 False True 3989832.7418704825 2083912.741735361 3736709.2611425025 1.0 0.5223057898809055 0.9365578716943126 21.92789683769366 -10.196542047211876 7.846900790343983 1.0000001341596318 0.7294318307876092 0.3625717963287165 0.16911770422141978 3.9699837717697013e-07 4.057958585496179e-08 0.16374759473959816 0.054582504333199215 6.360012259455067e-11 10.196542047211876 -0.27056830337202264 AFIITLNSFGTELSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFIITLNSFGTELSK 15 0 Q8N8Y2 Q8N8Y2 ATP6V0D2 V-type proton ATPase subunit d 2 0 44454000.0 18384000.0 15182000.0 10888000.0 False True 23798450.402816962 14337108.353949405 8906495.720314253 1.0 0.6024387349292438 0.3742468761436675 24.504364302074446 -9.337915254633643 0.14864883417577562 1.5656581230282187 1.0486620200330602e-11 0.999813130404231 0.0035345581672657266 0.7754723547698751 0.05518483136393978 0.37126339942399145 0.18302508990728614 4.592876264573407e-10 9.337915254633643 -1.565658123017732 AFISK(ub)VSTHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFISKVSTHK 10 1 O95905-2;O95905;O95905-3 O95905-2 ECD Protein SGT1 1 3737640.0 706250.0 996690.0 2034700.0 True False 683830.4803317051 1394673.5146696859 1501751.030308413 1.0 2.03950182798692 2.1960867108175113 19.383279203793904 -10.767585162597248 0.366217900298672 1.5242810938452894e-14 2.2184309308923305 0.9993202648086611 0.013838788098432737 2.4077212597827455 0.17843060782153944 2.1623427296812965 0.04412492343928141 1.7077128147708857e-11 10.767585162597248 2.2184309308923154 AFISK(ub)VSTHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFISKVSTHK 10 1 O95905-2;O95905;O95905-3 O95905-2 ECD Protein SGT1 1 2238550.0 696430.0 924730.0 617390.0 True False 953918.9913130903 883872.3709268218 471575.19754617865 1.0 0.9265696342937383 0.49435560235261183 19.86350722935399 -6.936241774321231 0.6936422259549417 1.0053078431143196 0.38964935071526124 0.9976290956743497 0.010862135036567338 0.08952368259435377 0.06273475142331818 0.010293589966449032 0.03785646539667209 1.1581324374403202e-07 6.936241774321231 -0.6156584923990585 down AFISK(ub)VSTHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFISKVSTHK 10 1 O95905-2;O95905;O95905-3 O95905-2 ECD Protein SGT1 1 3946040.0 706250.0 2305400.0 934390.0 True False 587278.1671799321 2292980.3526139306 1129766.6288687743 1.0 3.904419542147563 1.9237334060856257 19.16368447922818 -9.381007355470654 9.69658422335591 1.0000118827229072 2.9140764741165213 0.5545979133199366 0.8086117290218953 0.0 0.0 0.7829349399992818 0.2609783133330939 4.159035664432421e-10 9.381007355470654 1.914064591393614 AFITNIPFDVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFITNIPFDVK 11 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 45668000.0 9390000.0 17749000.0 18529000.0 False True 12310380.932889342 15100918.385060137 16611796.822718447 1.0 1.2266816492018848 1.3494137113447982 23.553372069534095 -12.764261266428386 0.08430257173671435 7.336452961033273e-20 1.710404634295478 0.9998960998279294 0.0014753077446602563 7.921560065754799 0.07126278368493133 1.6602636581325474 0.2930796646045716 1.7208330307149256e-13 12.764261266428386 1.710404634295478 AFITNIPFDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFITNIPFDVK 11 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 42588300.0 16387000.0 6227300.0 19974000.0 False True 15866803.654790306 8713893.3649405 14742210.192844292 1.0 0.5491902184287577 0.9291228727339491 23.91950819277361 -10.07206994856706 7.303832054428132 1.0000000435446383 0.7391565455813535 0.3859271187296286 0.15510685661149234 1.0998244235381738e-07 1.3941115129321249e-08 0.15018159387026175 0.05006052271157428 8.47090968540094e-11 10.07206994856706 -0.2608434979632849 AFITNIPFDVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFITNIPFDVK 11 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 59204000.0 9390000.0 24450000.0 25364000.0 False True 12861736.755208593 23369718.154662196 19373545.587977257 1.0 1.8169955270774925 1.5062931201831347 23.616582131056987 -10.151536903841206 4.656066721833824 0.9999258502946141 1.661644323637878 0.8580840672710349 0.12684372648356482 9.764763501554757e-05 1.779452318972464e-05 0.12282959565121376 0.04093863668314527 7.054448968635167e-11 10.151536903841206 0.6617184733432638 AFITNIPFDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFITNIPFDVK 11 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 27038500.0 16387000.0 6033200.0 4618300.0 False True 13626516.567189451 6000697.954103566 5583965.177393445 1.0 0.44036918199272734 0.40978669418997155 23.699913468207885 -13.847584584416781 0.4152201505941573 9.999839872015578 0.4085889038207358 0.9998560091408958 0.003255591010056605 25.502373859318073 0.21403050558538103 206.9516268271995 0.0075153906231707574 1.4204155417859536e-14 13.847584584416781 -9.591250968194842 AFITNIPFDVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFITNIPFDVK 11 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 17621800.0 6647600.0 5856100.0 5118100.0 False True 8605449.243786238 5530202.887074375 4186658.3161407383 1.0 0.6426396496461337 0.48651246408359344 23.03681907883135 -13.999999999990674 0.11259361571008496 2.717124662672075 0.21050770834840282 0.9997299144759306 0.0035322039091742834 11.998039838215107 0.10223751889250482 4.6618339172462475 0.2450168137991562 1.0000000000214736e-14 13.999999999990674 -2.5066169543236723 AFITNIPFDVK(ub)WQSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFITNIPFDVKWQSLK 16 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 76260000.0 31160000.0 22416000.0 22684000.0 True False 30170842.85612164 31366825.697895713 16742379.894586932 1.0 1.0396403523586484 0.5549191971343922 24.846651664553022 -6.887077759146406 1.0395560341133834 1.027898479390192 0.5155457855950928 0.9789594494035816 0.03187598249266915 0.12154443417056059 0.2359752650387613 0.023449341131591965 0.057874995249886686 1.2969470356515497e-07 6.887077759146406 -0.5123526937950992 AFITNIPFDVK(ub)WQSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFITNIPFDVKWQSLK 16 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 239684000.0 31905000.0 57552000.0 150227000.0 True False 48402217.56793507 47281395.94417165 120534567.60316676 1.0 0.9768435894039299 2.490269530192292 25.528569810905076 -6.903426167912131 0.9393486336225636 0.9428546858965545 2.6606646891026418 0.9881952615125185 0.07692837260314879 0.10892727057149076 0.16353583413314374 0.06100305499555815 0.1616305952048168 1.249032767939082e-07 6.903426167912131 1.7178100032060872 up AFITNIPFDVK(ub)WQSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFITNIPFDVKWQSLK 16 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 37671000.0 4120000.0 15354000.0 18197000.0 True False 5643275.338813569 14675609.51111178 13899243.378978958 1.0 2.6005481976353733 2.4629745217962564 22.42810131058643 -10.24379634536518 4.943206967613989 0.9997200245604762 2.5317613597172786 0.9939864600599682 0.056164217979214955 0.00017332649170130292 2.6515312776320082e-05 0.054390144834805025 0.01812692340646506 5.7043170332386676e-11 10.24379634536518 1.5320413351568023 AFITNIPFDVK(ub)WQSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFITNIPFDVKWQSLK 16 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 75584000.0 31160000.0 25264000.0 19160000.0 True False 25910920.62205546 25127897.817488607 23166267.414169367 1.0 0.9697802013294602 0.8940734971203673 24.6270569399873 -6.9554174174749175 0.49582187192838695 1.0015726502059283 0.8590388881454362 0.9995606531585975 0.0009338512896253816 0.08138063982253547 0.027503929471901344 0.0011039675201559467 0.006244413939365266 1.1081092559639266e-07 6.9554174174749175 -0.14253376206049218 AFITNIPFDVK(ub)WQSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFITNIPFDVKWQSLK 16 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 200092000.0 31905000.0 38838000.0 129349000.0 True False 41301651.44157288 36676631.158654206 105808809.23281841 1.0 0.8880185144784966 2.5618542004912364 25.299696132997525 -6.890893525919093 1.0170468346865928 0.9119802568690558 2.7083844988037766 0.9814652827212695 0.1040165568256644 0.11842254892291443 0.21761988682946232 0.07783180887790099 0.19467725206442138 1.2856018066892378e-07 6.890893525919093 1.7964042419347208 up AFK(ub)ELPVNAQNYVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFKELPVNAQNYVR 14 1 P30520 P30520 ADSS Adenylosuccinate synthetase isozyme 2 1 8548300.0 2077100.0 2846900.0 3624300.0 True False 2011163.597447055 3983682.0163873686 2674987.1033306057 1.0 1.9807846668685745 1.3300693721416794 20.939599011298505 -10.492900833564345 4.974599176097536 0.9980325249017806 1.6554270195051575 0.5749586268769751 0.2656534066510502 0.005811169962746238 0.0005923768429460994 0.25785773217275915 0.08573926831855015 3.2143944269614034e-11 10.492900833564345 0.6573944946033768 AFLADPSAFVAAAPVAAATTAAPAAAAAPAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFLADPSAFVAAAPVAAATTAAPAAAAAPAK 31 0 P05388;F8VWS0;P05388-2;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 0 37110600.0 1416700.0 26708900.0 8985000.0 False True 1857307.4193423167 22724036.2304768 8055318.3902059 1.0 12.23493536601685 4.337094821415366 20.824781197550543 -9.243201362659885 9.102561890115194 0.99999933706148 8.28601509372004 0.5315621941919422 3.2242799007041216 0.0 0.0 3.1218955897281235 1.0406318632427076 5.71213729356992e-10 9.243201362659885 7.286015756658561 AFLADPSAFVAAAPVAAATTAAPAAAAAPAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFLADPSAFVAAAPVAAATTAAPAAAAAPAK 31 0 P05388;F8VWS0;P05388-2;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 0 42772300.0 14892000.0 7321500.0 20558800.0 False True 14419261.611468686 10245013.13111812 15173833.529220337 1.0 0.7105088601048418 1.052330829281264 23.781493952455506 -6.6822972952058945 1.8939673315788073 0.8172090588498636 1.0510453099471813 0.3345176346168306 0.12263302345662666 0.43346543591318765 3.0082382276075426 0.05192080480482089 0.13652379164302686 2.0782735230836836e-07 6.6822972952058945 0.23383625109731765 AFLADPSAFVAAAPVAAATTAAPAAAAAPAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFLADPSAFVAAAPVAAATTAAPAAAAAPAK 31 0 P05388;F8VWS0;P05388-2;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 0 42037500.0 1416700.0 19264300.0 21356500.0 False True 1940492.2748779592 18413139.527478904 16312534.550923996 1.0 9.48890122669359 8.40638984349985 20.887991259073434 -10.22500800603895 7.625995865095073 0.9999902241900965 8.94764553509672 0.9862770289609948 0.4419334215965161 7.344907217671264e-05 7.471542411690199e-06 0.42790071835829213 0.14263339849798073 5.956511628452473e-11 10.22500800603895 7.947655310906624 AFLADPSAFVAAAPVAAATTAAPAAAAAPAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFLADPSAFVAAAPVAAATTAAPAAAAAPAK 31 0 P05388;F8VWS0;P05388-2;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 0 18432100.0 14892000.0 1659700.0 1880400.0 False True 12383357.827459902 1650758.8666753448 2273582.9460127354 1.0 0.13330462461601594 0.1835998747424629 23.561899227889782 -10.49383456455043 5.8862192714540615 1.0008824254450672 0.1584522496792392 0.9973282498865527 0.02053294988257508 0.0002379908209564793 2.0465164150174923e-05 0.01989892354728477 0.006626981078643627 3.207490918770036e-11 10.49383456455043 -0.842430175765828 AFLADPSAFVAAAPVAAATTAAPAAAAAPAK(ub)VEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAK 35 1 P05388;F8VWS0;P05388-2;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 1 11350100.0 4278100.0 5382400.0 1689600.0 True False 5608630.529179332 4579366.900430875 1514776.3997876341 1.0 0.816485749347611 0.2700795482795476 22.419217117350602 -6.951620032787026 0.5407652589397961 1.00800426178929 0.05329483669577709 0.9993223656917289 0.008070299892193574 0.08284165141454275 0.033319953370816065 0.008867113997802455 0.04525573026704512 1.1178408266587248e-07 6.951620032787026 -0.9547094250935129 down AFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAK 35 1 P05388;F8VWS0;P05388-2;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 1 51919000.0 21404000.0 20412000.0 10103000.0 True False 20724541.735957235 28562618.04717377 7456721.216496734 1.0 1.3782026358448936 0.3598015006314599 24.304836865205353 -6.806152250458271 1.4306030265364962 1.2070808584559 0.34350723620195384 0.8495288024260411 0.16304534228092446 0.21211138407054453 0.8562782784649164 0.08963190360874658 0.2077258080061692 1.5625997465849306e-07 6.806152250458271 -0.8635736222539463 down AFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAK 35 1 P05388;F8VWS0;P05388-2;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 1 83743000.0 32494000.0 30192000.0 21057000.0 True False 49295773.62960289 24804001.70882729 16895074.720389027 1.0 0.5031669022013704 0.34272866569322424 25.55496062673797 -13.999999999999998 0.15810293577197457 3.4372795450603317 0.18166144918409324 0.9995414872377708 0.00599131615021951 11.997569662973874 0.12558743521690827 8.968682272761932 0.14645671125259477 1.0000000000000041e-14 13.999999999999998 -3.2556180958762386 AFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAK 35 1 P05388;F8VWS0;P05388-2;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 1 47513200.0 21404000.0 18648000.0 7461200.0 True False 17798374.357974164 18547539.522661798 9021302.42330901 1.0 1.0420917747666087 0.5068610335902513 24.08524214063963 -6.887889489653171 1.03481649057884 1.030230573527261 0.46269058921997314 0.9795115964478349 0.034782093000088186 0.12087100868909302 0.23199906894755742 0.025679286494160618 0.0635495349216229 1.2945252037501375e-07 6.887889489653171 -0.5675399843072879 AFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFLADPSAFVAAAPVAAATTAAPAAAAAPAKVEAK 35 1 P05388;F8VWS0;P05388-2;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 1 101600000.0 32494000.0 47607000.0 21499000.0 True False 42064123.552498594 44957628.60008366 17586402.598368477 1.0 1.0687879552268287 0.4180855587403259 25.32608694883042 -6.880772758541695 1.0755226384248724 1.043080383765332 0.37128972673762356 0.9743016184231057 0.04679119436247795 0.12694580694211036 0.26819157597224874 0.033490687886049836 0.08114748396453701 1.315913194183225e-07 6.880772758541695 -0.6717906570277083 down AFLDALQNQAEASSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFLDALQNQAEASSK 15 0 Q12931-2;Q12931 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 11821800.0 1003400.0 4858500.0 5959900.0 False True 1315467.1169394224 4133630.7382846675 5343226.719397682 1.0 3.1423292038663875 4.061847423316275 20.327143754869894 -9.170859822333588 0.2925000251247908 1.6121336548352233e-20 4.484345961581945 0.9987207943472014 0.045880318494267304 0.5952631080982483 0.10699949008848801 0.9539671817739633 0.32643245495754736 6.74745780927681e-10 9.170859822333588 4.484345961581945 AFLDALQNQAEASSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFLDALQNQAEASSK 15 0 Q12931-2;Q12931 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 16703900.0 4291300.0 2717700.0 9694900.0 False True 4155075.0304388627 3802891.7826182744 7155514.849234298 1.0 0.9152402194327186 1.7221144737014595 21.986443098080258 -6.880945136665446 1.0744832582633053 0.9467774243014245 1.7803508563687003 0.974441142105801 0.057880396658094836 0.12679755465038803 0.2672382628598747 0.04145903006254111 0.10050625358585731 1.3153909917473957e-07 6.880945136665446 0.8335734320672757 AFLDALQNQAEASSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFLDALQNQAEASSK 15 0 Q12931-2;Q12931 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 16850500.0 1003400.0 7624600.0 8222500.0 False True 1374384.095865422 7287719.960819524 6280514.847703151 1.0 5.302535137552355 4.569694066307162 20.390353816392786 -10.463597799326967 5.2357097730308615 0.9938818312198323 4.9361146019298126 0.9746604590143819 0.2991811145177593 0.021282693140969824 0.002180425492404105 0.2885449180004283 0.09656028950222538 3.438762647272168e-11 10.463597799326967 3.94223277070998 AFLDFHALPYQVVEVNPVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFLDFHALPYQVVEVNPVR 19 0 Q9H7Z7 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 0 19284300.0 8455400.0 4732500.0 6096400.0 False True 8186987.955251954 6622211.929661478 4499569.95192029 1.0 0.808870364272776 0.5496001675480437 22.96490134215695 -6.9668744440790285 0.3242792229684174 1.0337703572487331 0.3162846046442646 0.9999467287206447 0.0013471488919960123 0.07733055504477573 0.012647399083988667 0.0038641816462202097 0.02272148737922497 1.0792586942650696e-07 6.9668744440790285 -0.7174857526044685 AFLDFHALPYQVVEVNPVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFLDFHALPYQVVEVNPVR 19 0 Q9H7Z7 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 0 16984100.0 8455400.0 2822200.0 5706500.0 False True 7031039.737731953 2806996.248437159 6899702.766125122 1.0 0.39922918275848485 0.9813204054441602 22.745306617591226 -10.921823808979145 10.727003556189878 1.044913848655774 0.6902747941013225 0.27404387943908404 0.23763774655544675 0.1311354280362057 0.000955686479736 0.11820749111837428 0.07669725290329202 1.1972261412375092e-11 10.921823808979145 -0.35463905455445155 AFLDFHALPYQVVEVNPVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFLDFHALPYQVVEVNPVR 19 0 Q9H7Z7 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 0 8248100.0 1862500.0 4274900.0 2110700.0 False True 2411042.96536372 4036998.057060885 1726574.2576108815 1.0 1.6743783147190328 0.7161109455178944 21.20122592966522 -6.717593977512902 1.7679198273888297 1.411342618870796 0.7178036057771376 0.5010944680057047 0.28386944362329186 0.36004989895510836 2.1979632215438563 0.12755579363994787 0.32112890509785585 1.9160464022534562e-07 6.717593977512902 -0.6935390130936584 AFLDFYHSFLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFLDFYHSFLEK 12 0 M0QZR4;Q92888;Q92888-3 M0QZR4 ARHGEF1 Rho guanine nucleotide exchange factor 1 0 4829500.0 1349000.0 1808900.0 1671600.0 False True 1768552.063734584 1539019.1710369757 1498638.8671194415 1.0 0.8702142292532161 0.8473818203320647 20.754137259941228 -13.999999999991225 0.2444368317575309 1.8779001489375315 0.8377028863071062 0.9995325436136798 0.0014531777331956582 13.784347161361708 0.15646208976895262 5.922306265652824 0.010873230068792148 1.0000000000202057e-14 13.999999999991225 -1.0401972626304254 AFLDFYHSFLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFLDFYHSFLEK 12 0 M0QZR4;Q92888;Q92888-3 M0QZR4 ARHGEF1 Rho guanine nucleotide exchange factor 1 0 7739300.0 2296100.0 2659000.0 2784200.0 False True 2223211.5623215963 3720752.566501814 2054934.4957903817 1.0 1.6735935659746233 0.9243090179166347 21.084213812061222 -6.66983385370699 1.9383580838036407 1.4300194420023162 0.9273647758302346 0.2781914960917423 0.2861396890001765 0.4614672355003834 3.3426425540106406 0.11886014008916854 0.3175874676920524 2.138780157531468e-07 6.66983385370699 -0.5026546661720817 AFLDFYHSFLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFLDFYHSFLEK 12 0 M0QZR4;Q92888;Q92888-3 M0QZR4 ARHGEF1 Rho guanine nucleotide exchange factor 1 0 9137000.0 1349000.0 2485900.0 5302100.0 False True 1847761.7553542505 2376064.718228008 4049853.180177189 1.0 1.2859150869114466 2.1917615560782924 20.81734732146412 -6.950218111509551 0.5564459425686483 0.9879249271850237 2.5327801404528913 0.9992182750641752 0.014203421792866176 0.08339832249165516 0.035601109191869575 0.015291453014475431 0.07524356786392442 1.1214550953224552e-07 6.950218111509551 1.5448552132678677 up AFLDFYHSFLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFLDFYHSFLEK 12 0 M0QZR4;Q92888;Q92888-3 M0QZR4 ARHGEF1 Rho guanine nucleotide exchange factor 1 0 6046400.0 2296100.0 2153000.0 1597300.0 False True 1909308.8844769436 2141401.361662962 1931288.0449192417 1.0 1.1215583707136 1.0115115792007217 20.864619087495498 -10.798286794718711 3.3276766108260705 0.9858155114037117 1.066534974962291 0.32768509806181856 0.04492641452223926 33434775.579661965 23939.410166692607 3633709.6487157806 0.015379506503666686 1.5911576284724955e-11 10.798286794718711 0.08071946355857929 AFLEILHTYQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFLEILHTYQK 11 0 Q96ST3 Q96ST3 SIN3A Paired amphipathic helix protein Sin3a 0 16366200.0 3877700.0 5053700.0 7434800.0 False True 5083702.251700221 4299707.659168313 6665518.215637494 1.0 0.8457827477465455 1.311154329191534 22.277448104668075 -6.817384214653991 1.3829971997528177 0.9166459392883592 1.3207658998573852 0.8782661454560907 0.06753195705826016 0.19692407897789468 0.7407738501546081 0.03837672359641018 0.08852651201526869 1.5227050404781602e-07 6.817384214653991 0.404119960569026 AFLEILHTYQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFLEILHTYQK 11 0 Q96ST3 Q96ST3 SIN3A Paired amphipathic helix protein Sin3a 0 8551500.0 2431200.0 2719200.0 3401100.0 False True 2354022.886771597 3804990.7404406746 2510249.879187079 1.0 1.6163779722885339 1.0663659615602712 21.166696916238923 -10.237667744164913 4.496455997735591 0.9998725283192826 1.3413719669278192 0.3393364153741989 0.22454146312650383 0.0002870541708344244 4.866760249968188e-05 0.21749213953574817 0.07247044560013419 5.785384874671789e-11 10.237667744164913 0.3414994386085366 AFLEILHTYQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFLEILHTYQK 11 0 Q96ST3 Q96ST3 SIN3A Paired amphipathic helix protein Sin3a 0 10014000.0 3877700.0 1814700.0 4321600.0 False True 5311390.480902282 1734520.55358959 3300927.086145817 1.0 0.3265661901203195 0.6214807775882194 22.340658166190966 -10.463639737880351 6.164105385841008 1.0002598873696968 0.47402348385450144 0.8092005086262941 0.12039837616662566 0.00043021580869625836 3.743446617600464e-05 0.11663123024804174 0.038858408816979745 3.4384305920105984e-11 10.463639737880351 -0.5262364035151954 AFLEILHTYQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFLEILHTYQK 11 0 Q96ST3 Q96ST3 SIN3A Paired amphipathic helix protein Sin3a 0 7789320.0 2431200.0 1234100.0 4124020.0 False True 2021650.5204217345 1227451.6583503296 4986333.514685942 1.0 0.6071532373925203 2.4664666144402383 20.9471021916732 -6.851517835646125 1.2278720302528072 0.7900751908032736 2.5429442869556103 0.9424671892366395 0.1919196165121898 0.15579736848490386 0.4512661241100492 0.12226220239316314 0.2831877351877554 1.4076094193408305e-07 6.851517835646125 1.7528690961523368 up AFLGQVLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFLGQVLVR 9 0 A2IDA3;P29372-5;P29372-4;P29372-2;P29372 A2IDA3 MPG DNA-3-methyladenine glycosylase 0 5108400.0 1482300.0 1409400.0 2216700.0 False True 1943309.6546136176 1199123.0137981714 1987337.1480878617 1.0 0.6170519510111678 1.02265593307259 20.890084373274263 -9.012920226678869 12.534520942635227 1.0000086763900626 0.8198539420418749 0.20824502741185125 0.16558713235769626 0.0 0.0 0.16032905145765677 0.05344301715255225 9.70688251606573e-10 9.012920226678869 -0.18015473434818774 AFLGQVLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFLGQVLVR 9 0 A2IDA3;P29372-5;P29372-4;P29372-2;P29372 A2IDA3 MPG DNA-3-methyladenine glycosylase 0 4868330.0 1804800.0 444630.0 2618900.0 False True 1747507.6118975715 622173.0777148189 1932931.5246840853 1.0 0.35603454513094673 1.1061076424068716 20.73686730911542 -6.6794363359022135 1.9036338308538465 0.5923588994938153 1.1032589273759292 0.32167595965836915 0.27295990884041316 0.43976661627138697 3.0805798750351183 0.11507060600217131 0.3037388516416254 2.09200955649631e-07 6.6794363359022135 0.510900027882114 AFLGQVLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFLGQVLVR 9 0 A2IDA3;P29372-5;P29372-4;P29372-2;P29372 A2IDA3 MPG DNA-3-methyladenine glycosylase 0 4265200.0 1482300.0 1267000.0 1515900.0 False True 2030346.3676512984 1211019.7505912897 1157875.6409404946 1.0 0.5964596828826776 0.5702847846005327 20.953294434797154 -13.999999999999998 0.38882987550871295 7.332918211034021 0.568332159970419 0.9998213625607045 0.0026288694443743488 25.19116606496795 0.2042742819577697 134.018646713253 0.006912546060986964 1.0000000000000041e-14 13.999999999999998 -6.764586051063602 AFLLSLAALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFLLSLAALR 10 0 Q8IV08 Q8IV08 PLD3 Phospholipase D3 0 2910420.0 477720.0 2008700.0 424000.0 False True 626295.5462470602 1709009.789851275 380128.54729519226 1.0 2.728759289591223 0.6069475498796533 19.25648409403074 -6.690034478270675 1.8661618411518355 2.083756263509976 0.6142360512434364 0.3707158305899224 0.7311325494358739 0.4165532540621182 2.8125931703168896 0.3134107841629915 0.816147521911981 2.0415758592593105e-07 6.690034478270675 -1.4695202122665394 AFLLSLAALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFLLSLAALR 10 0 Q8IV08 Q8IV08 PLD3 Phospholipase D3 0 19126600.0 6330200.0 5775000.0 7021400.0 False True 9603376.199609531 4744406.129719052 5633617.212411052 1.0 0.494035225852337 0.5866288162948476 23.195110263713197 -10.075881987381887 5.307039152949299 1.0000057294587974 0.54033202107314 0.9704664834418256 0.037801175007871515 2.562572877153597e-06 4.4623064994260237e-07 0.03660128608600422 0.012200276772452607 8.396881274147604e-11 10.075881987381887 -0.45967370838565735 AFLLSLAALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFLLSLAALR 10 0 Q8IV08 Q8IV08 PLD3 Phospholipase D3 0 6654820.0 477720.0 1613100.0 4564000.0 False True 654345.9938975769 1541827.9081916378 3486077.1985305245 1.0 2.3562884507137003 5.327574755621093 19.31969415555363 -6.958224777114612 0.4597693736378483 0.9131925760256252 6.890402661484776 0.9996985879871857 0.03137638240899728 0.08034146077520442 0.023521243167286533 0.040337631189212166 0.24546432821962694 1.1009693350798178e-07 6.958224777114612 5.977210085459151 AFLLSLAALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFLLSLAALR 10 0 Q8IV08 Q8IV08 PLD3 Phospholipase D3 0 6205900.0 2875200.0 1154900.0 2175800.0 False True 2390856.192956801 1148678.324470299 2630749.720237456 1.0 0.4804464308033996 1.1003379157589463 21.189095925660848 -6.684387003590429 1.8859836458650006 0.6725664868639555 1.098078214961473 0.3442816036022198 0.219993293793532 0.4289503836742822 2.9534402167576297 0.09346288864623199 0.2451538887185517 2.0682974495078723e-07 6.684387003590429 0.42551172809751747 AFLLSLAALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFLLSLAALR 10 0 Q8IV08 Q8IV08 PLD3 Phospholipase D3 0 18885700.0 6330200.0 8457100.0 4098400.0 False True 8194568.686896857 7986454.950611629 3352533.253135185 1.0 0.9746034545273868 0.4091164991387402 22.966236585805646 -6.916298610912432 0.8517249875415928 1.0142178893782279 0.3252619281528493 0.9930894464793673 0.022674155938915017 0.10039907178759921 0.11726084904388756 0.019162393897938022 0.055517783729654775 1.212554838912632e-07 6.916298610912432 -0.6889559612253786 down AFLNAIMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFLNAIMR 8 0 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y7I0;A0A2R8Y7M9;A0A2R8Y5M9;A0A2R8YE38;K7EMY3;Q8TDI0 A0A2R8YFD8 CHD4;CHD5 Chromodomain-helicase-DNA-binding protein 4;Chromodomain-helicase-DNA-binding protein 5 0 8429900.0 2470900.0 2451000.0 3508000.0 False True 3239373.8282296415 2085320.3539231727 3145025.8111121124 1.0 0.6437418045890759 0.9708746127738238 21.62728353607188 -10.416742619516334 8.409118332383805 1.000002399843362 0.807308209463167 0.3162917085149699 0.13355140969606613 6.008913229332626e-06 4.1658963848787733e-07 0.12931220701063853 0.04310353213461565 3.8305168799233996e-11 10.416742619516334 -0.19269419038019509 AFLNAIMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFLNAIMR 8 0 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y7I0;A0A2R8Y7M9;A0A2R8Y5M9;A0A2R8YE38;K7EMY3;Q8TDI0 A0A2R8YFD8 CHD4;CHD5 Chromodomain-helicase-DNA-binding protein 4;Chromodomain-helicase-DNA-binding protein 5 0 8334100.0 2470900.0 2640900.0 3222300.0 False True 3384458.503561765 2524216.305711547 2461259.1053516422 1.0 0.7458257511667201 0.7272238979326949 21.69049359759477 -13.999999999999998 0.3710662044766135 4.564264728940807 0.7253275976893934 0.9997927187380556 0.0017915193291751811 22.944686355652106 0.19781590843881397 65.082278712766 0.005181443288370299 1.0000000000000041e-14 13.999999999999998 -3.838937131251414 AFMAAQKCHK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFMAAQKCHK 10 1 H0YBR2;H0YBB3;A0A2U3TZN9;Q6NXG1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1 H0YBR2 ESRP1 Epithelial splicing regulatory protein 1 1 3033850.0 939980.0 908470.0 1185400.0 True False 1287516.008004363 868330.7914914495 905432.9340793347 1.0 0.6744232973362044 0.7032401371713792 20.296158939115127 -10.0817974367096 5.2488962831271575 1.0000047146033766 0.688831717253362 0.9936088519330959 0.011764425600783482 6.490721147687065e-07 1.1354093774339176e-07 0.011391028693076672 0.0037969520355777015 8.283284219167504e-11 10.0817974367096 -0.3111729973500146 AFMECQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFMECQKR 8 1 Q12789;Q12789-3;I3L1Z3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 1569250.0 386010.0 558890.0 624350.0 True False 528728.3285280165 534196.3917979201 476891.38889187813 1.0 1.0103419146939352 0.9019592164080696 19.012167100818996 -6.883499967903143 1.0600452479307498 1.0067628070914076 0.8937421330577854 0.9764023677322382 0.007502153851054807 0.12457675931526156 0.25391250052140457 0.005433241229117042 0.013264442897885618 1.3076756355649578e-07 6.883499967903143 -0.11302067403362226 AFNQGK(ub)IFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFNQGKIFK 9 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 3120430.0 0.0 2147090.0 973340.0 True False 0.0 2135523.2000060016 1176860.893784322 0.0 AFNSSSFNSNTFLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFNSSSFNSNTFLTR 15 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 37413000.0 11053000.0 12078000.0 14282000.0 False True 14490590.03740426 10276009.479675252 12804235.642617783 1.0 0.7091505213486823 0.8836241733129206 23.7886130049108 -10.285522036711292 5.4553033056252165 1.000025769722386 0.7963873478561361 0.6448719734266081 0.07122857014541562 2.232750972770989e-05 2.924251210442423e-06 0.06897548717654234 0.02298892216227603 5.181767983224362e-11 10.285522036711292 -0.20363842186624992 AFNSSSFNSNTFLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFNSSSFNSNTFLTR 15 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 29188000.0 8225300.0 3477700.0 17485000.0 False True 7964192.353801592 4866363.745965916 12905153.961243717 1.0 0.6110304133529657 1.6203970707819015 22.925096635250043 -6.802231143081796 1.4466959230666498 0.7859836756914026 1.635121605732878 0.8386021740300127 0.16699147703186187 0.2176064673071866 0.8988798398260582 0.09079558208469847 0.21088520245507766 1.576771846395818e-07 6.802231143081796 0.8491379300414753 AFNSSSFNSNTFLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFNSSSFNSNTFLTR 15 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 31499800.0 11053000.0 11353000.0 9093800.0 False True 15139592.796093788 10851386.92064948 6946031.732689935 1.0 0.7167555341019 0.4587991121189271 23.851823066433692 -6.972240748261372 0.1974679996229457 1.15864894047123 0.00980299155166264 0.9999949898199832 0.0004946954779527959 0.07558215944607657 0.006356231481140397 0.008552159018098006 0.027563235873728057 1.0660050246053795e-07 6.972240748261372 -1.1488459489195673 down AFNSSSFNSNTFLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFNSSSFNSNTFLTR 15 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 18683300.0 8225300.0 5467000.0 4991000.0 False True 6839701.3925735885 5437548.185885469 6034595.024223344 1.0 0.79499789154384 0.8822892518049965 22.70550191068432 -10.143360432941197 4.742336076799934 1.0000130989014784 0.8386435717240281 0.8200093118534073 0.03563654860697167 5.265465615043643e-06 9.511699662336274e-07 0.034507927023643435 0.011501646604747331 7.188521352018616e-11 10.143360432941197 -0.16136952717745023 AFQDLLDQVGGLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFQDLLDQVGGLGR 14 0 E9PJ86;Q6T423 E9PJ86 SLC22A25 Solute carrier family 22 member 25 0 1379330000.0 265410000.0 459760000.0 654160000.0 False True 343578477.0132536 434173951.8384787 535109592.2484169 1.0 1.2636820432198677 1.5574595850710837 28.356064422819745 -6.969728603302115 0.26458733162545406 0.9220068076783404 1.9079033962448064 0.9999801875614105 0.001013469174815301 0.07639086653223291 0.009344753487483029 0.005955708865099735 0.02753204033774812 1.0721891219100095e-07 6.969728603302115 0.985896588566466 AFQEGIAK(ub)AK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFQEGIAKAK 10 1 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 2 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 AFQGLLDTYSVWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFQGLLDTYSVWR 13 0 Q6XQN6;G5E977;Q6XQN6-3;Q6XQN6-2;C9J8U2 Q6XQN6 NAPRT Nicotinate phosphoribosyltransferase 0 11822100.0 3555700.0 2532500.0 5733900.0 False True 3442826.2497917805 3543740.456813033 4232019.576687179 1.0 1.029311443476811 1.2292283344078512 21.71516194311933 -6.933186273302853 0.7201483177383454 0.9972900488984685 1.2738131682733382 0.9971284341298098 0.005458146475642277 0.09101648537660739 0.06981788408558934 0.005070505154683324 0.017782692399043117 1.1663092679060698e-07 6.933186273302853 0.27652311937486973 AFQGLLDTYSVWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFQGLLDTYSVWR 13 0 Q6XQN6;G5E977;Q6XQN6-3;Q6XQN6-2;C9J8U2 Q6XQN6 NAPRT Nicotinate phosphoribosyltransferase 0 6004300.0 3555700.0 2448600.0 0.0 False True 2956722.094218316 2435408.905790952 0.0 1.0 0.8236854287229906 0.0 21.495567218553607 -7.215004581357979 0.8801348559442062 0.990170115516543 9.560114512276254e-16 0.9891980606326918 0.04529703925100284 0.09446843555790119 0.1396515081907395 0.038232506542854004 0.06716569961227063 6.095304672897206e-08 7.215004581357979 -0.990170115516542 down AFQK(ub)MDTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFQKMDTK 8 1 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 1 3076900.0 1176400.0 1900500.0 0.0 True False 1542271.7922738048 1616952.8080909774 0.0 1.0 1.0484227333932294 0.0 20.55662560099266 -6.989885399346644 1.1374905194260019 1.0385121312122683 4.88877080278015e-19 0.9815793791990091 0.06558419426626959 0.09437375316721688 0.23979716405901297 0.04847122493283644 0.08945742497543029 1.023563052169186e-07 6.989885399346644 -1.0385121312122683 down AFQK(ub)MDTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFQKMDTK 8 1 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 1 6303400.0 1668600.0 2396100.0 2238700.0 True False 1615631.2063454625 3352875.225496432 1652317.3104395973 1.0 2.0752726317292383 1.02270697913611 20.623666486784472 -6.641180950363693 2.039837235593302 1.7025189926559492 1.0270603622073278 0.1592920178781212 0.459937821523702 0.5303895926725251 4.219213985038411 0.18350912164074626 0.5094169687054954 2.2846466987456559e-07 6.641180950363693 -0.6754586304486214 AFQK(ub)MDTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFQKMDTK 8 1 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 1 4458600.0 1176400.0 1618400.0 1663800.0 True False 1611346.8710146316 1546893.7366668829 1270844.7070366088 1.0 0.9600004595489958 0.7886847518041751 20.619835662515552 -6.943307564428497 0.6280403491864845 1.0018689534199072 0.737614257816958 0.9985658069759988 0.003470978698230071 0.08628961852067334 0.04797804842082073 0.003470335431609265 0.014543690296526846 1.1394425562092035e-07 6.943307564428497 -0.26425469560294923 AFQK(ub)MDTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFQKMDTK 8 1 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 1 5910000.0 1668600.0 2886400.0 1355000.0 True False 1387514.8315135357 2870850.390294458 1638324.2351878625 1.0 2.069059245415678 1.1807616019504006 20.40407176221875 -10.25353217840785 4.2158684137547935 0.9995551287007546 1.6249104237066552 0.3975425576737657 0.3626459944485586 256270236.64151308 848.509915457782 1108174.663514691 0.12414336970585503 5.57786272260517e-11 10.25353217840785 0.6253552950059006 AFQQLEHK(ub)FGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFQQLEHKFGR 11 1 Q9H0U9 Q9H0U9 TSPYL1 Testis-specific Y-encoded-like protein 1 1 21330200.0 8897100.0 5180600.0 7252500.0 True False 11664184.25963897 4407674.67382064 6502080.870892409 1.0 0.37788109101399486 0.5574398282948302 23.47558207948694 -10.907095656240338 11.43530709023667 1.0461104142998807 0.4676604596544126 0.921379559271165 0.07330454753275094 0.03785960268727398 0.00030758376062659827 0.031182629017984104 0.023658940982967867 1.2385237634118333e-11 10.907095656240338 -0.5784499546454681 AFQQLEHK(ub)FGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFQQLEHKFGR 11 1 Q9H0U9 Q9H0U9 TSPYL1 Testis-specific Y-encoded-like protein 1 1 19431600.0 8897100.0 5140100.0 5394400.0 True False 12186598.305086957 4912993.385962338 4120353.821155356 1.0 0.4031472329658676 0.33810532832902424 23.538792141009832 -13.999999999999998 0.3130266843549674 6.872684649852553 0.32416352586578545 0.9996786285367479 0.005339961933733628 17.488089943925367 0.1781340081553339 67.00518836038695 0.022263468147532994 1.0000000000000041e-14 13.999999999999998 -6.5485211239867676 AFQQLEHK(ub)FGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFQQLEHKFGR 11 1 Q9H0U9 Q9H0U9 TSPYL1 Testis-specific Y-encoded-like protein 1 1 44994500.0 9073500.0 16040000.0 19881000.0 True False 11745824.615424259 15147359.899706794 16262861.996286495 1.0 1.2895952728440832 1.384565369291365 23.485644665498803 -12.920626950725223 0.16935408266890864 1.1869740120838325e-09 1.4733801739303773 0.999503947231438 0.0036429069088770613 7.979601228626342 0.12159566510329695 2.738359564522111 0.07755914710691769 1.2005300889484407e-13 12.920626950725223 1.4733801727434033 AFQYVETHGEVCPANWTPDSPTIKPSPAASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFQYVETHGEVCPANWTPDSPTIKPSPAASK 31 1 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 48455600.0 9011600.0 24653000.0 14791000.0 False True 11814294.86845855 20974868.49664136 13260569.205290558 1.0 1.7753804801875595 1.122417321806757 23.49403018940686 -10.189801177071676 4.461224471865043 0.999897676696566 1.4488989006448736 0.3865674490789871 0.26657109320440425 187206339.505623 42.80153226579839 209726.660969201 0.09125437557012142 6.459498815443196e-11 10.189801177071676 0.44900122394830755 AFQYVETHGEVCPANWTPDSPTIKPSPAASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFQYVETHGEVCPANWTPDSPTIKPSPAASK 31 1 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 24953400.0 11777000.0 4188500.0 8987900.0 False True 11403145.58140388 5860989.892738951 6633699.358779671 1.0 0.5139800988156275 0.5817429332479831 23.442928513927022 -10.52805688535378 6.267523016790035 1.0004981465651774 0.5478615160319096 0.9834329111933493 0.02766406131399503 0.00019276428062800995 1.451506145179321e-05 0.026813731954775516 0.008928537396463628 2.964443071356667e-11 10.52805688535378 -0.45263663053326786 AFQYVETHGEVCPANWTPDSPTIKPSPAASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFQYVETHGEVCPANWTPDSPTIKPSPAASK 31 1 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 47549600.0 9011600.0 15401000.0 23137000.0 False True 12343432.049333114 14720532.895703584 17672517.121472552 1.0 1.1925802189269474 1.4317344682451876 23.557240250929752 -6.968205551655735 0.29794634290259303 0.9574972456836158 1.6742893371450276 0.9999648063704047 0.0010476283497766832 0.07688935324887228 0.011103165035738468 0.004008623703832908 0.021495816981860823 1.0759558430043654e-07 6.968205551655735 0.7167920914614118 AFQYVETHGEVCPANWTPDSPTIKPSPAASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFQYVETHGEVCPANWTPDSPTIKPSPAASK 31 1 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 76307000.0 13073000.0 29293000.0 33941000.0 False True 16923256.207355645 27662818.79938352 27764086.264069237 1.0 1.6346037937639895 1.6405877169194931 24.0125038486405 -11.258680863243136 0.750708333757219 6.554020436902692e-05 1.6394110947003768 0.9999891857842761 0.0009884247476167347 4.115827411307788 0.3924623761265131 6.881981348275935 0.0008944210677598055 5.512126004306212e-12 11.258680863243136 1.6393455544960078 AFRNIPGITLLNVSKLNILKLAPGGHVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFRNIPGITLLNVSKLNILKLAPGGHVGR 29 3 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 22536300.0 4260100.0 2532300.0 15743900.0 False True 4124865.4573608385 3543460.595770047 11620100.283124125 1.0 0.8590487695657388 2.8170858912229515 21.97591563240048 -6.889597545171503 1.0247365219118805 0.8937753651046015 2.984188413097107 0.9806403065607716 0.12406530154525035 0.11947124995328559 0.2237480082004534 0.09229582640224047 0.22976943249989065 1.2894439084584308e-07 6.889597545171503 2.0904130479925054 up AFRNIPGITLLNVSKLNILKLAPGGHVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFRNIPGITLLNVSKLNILKLAPGGHVGR 29 3 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 15601600.0 4260100.0 4355800.0 6985700.0 False True 3542461.904429345 4332334.440841394 8446377.571772583 1.0 1.2229727680132354 2.384324178959155 21.756320907834755 -6.938899143809251 0.669736825680304 0.9866830039389891 2.6876051046671883 0.9980159945358833 0.0270320708084876 0.08827265276638616 0.056925947895026134 0.026099047593640998 0.10044984563753934 1.151067670308457e-07 6.938899143809251 1.7009221007281992 up AFSIASSLLTHPSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFSIASSLLTHPSR 14 0 Q9UHB4-3;Q9UHB4;Q9UHB4-2 Q9UHB4-3 NDOR1 NADPH-dependent diflavin oxidoreductase 1 0 4154000.0 1393400.0 1483500.0 1277100.0 False True 1908577.6352191318 1417954.0647215291 975475.2827001169 1.0 0.7429375879481727 0.5111006566877844 20.864066441582448 -6.972352180627471 0.19394150484009623 1.1492585076302864 0.09842008203714481 0.9999953870105415 0.0004288331144484578 0.07554659771386679 0.006216174541394654 0.007916102933261714 0.025003146051992383 1.0657315414527601e-07 6.972352180627471 -1.0508384255931416 AFSITQGLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFSITQGLLK 10 0 O15067;J3KTQ5 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 14055900.0 4100500.0 4530900.0 5424500.0 False True 5375795.209298488 3854907.381309869 4863224.775478235 1.0 0.717085980999063 0.9046521651469048 22.35804674907831 -10.417848355047758 6.6225517613443525 1.0000263895742423 0.8108690730729846 0.5754927526960826 0.07657357402718656 2.9840120853576274e-05 2.623042594452725e-06 0.07415237765763036 0.02471401474723952 3.8207765967275726e-11 10.417848355047758 -0.18915731650125767 AFSITQGLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFSITQGLLK 10 0 O15067;J3KTQ5 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 7708400.0 3105200.0 1037200.0 3566000.0 False True 3006627.125700544 1451359.3689265475 2631957.6222931175 1.0 0.48272010736561843 0.8753854443057588 21.519714528935943 -9.79476811501804 6.217450733407165 1.0000000103030016 0.679052775835437 0.4711122297831517 0.16030495253113788 2.2904999836681776e-08 4.463973514765386e-09 0.15521460749226845 0.051738200955505416 1.6041016479342734e-10 9.79476811501804 -0.32094723446756457 AFSITQGLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFSITQGLLK 10 0 O15067;J3KTQ5 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 15848100.0 4100500.0 4660600.0 7087000.0 False True 5616565.661845888 4454679.2814568 5413196.561346587 1.0 0.7931322358996097 0.9637912003983474 22.4212568106012 -10.036815900812366 5.753390574254804 1.0000003492519132 0.8784617181971296 0.4034299591160492 0.06967123050903765 3.121782018632104e-07 5.224070900520803e-08 0.06745907287343196 0.02248629295592624 9.187219639073403e-11 10.036815900812366 -0.12153863105478357 AFSITQGLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFSITQGLLK 10 0 O15067;J3KTQ5 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 6820400.0 3105200.0 2448300.0 1266900.0 False True 2582111.3836844233 2435110.5219505 1531802.9325162407 1.0 0.9430695117713446 0.5932365823547495 21.30011980437022 -6.9353320035091635 0.7016465419720047 1.0044168887914298 0.5105832581367761 0.9974862935376055 0.009016595679815605 0.08996226906991686 0.06479988010532231 0.008492829940555804 0.030778999376196572 1.1605610647737638e-07 6.9353320035091635 -0.4938336306546537 AFSLAK(ub)NSQPNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFSLAKNSQPNR 12 1 P50750;P50750-2 P50750 CDK9 Cyclin-dependent kinase 9 1 5319100.0 1293300.0 1130700.0 2895100.0 True False 1695528.8243350156 962003.9674340799 2595542.8237601696 1.0 0.5673769467242037 1.5308161008575825 20.693303880005246 -6.784615689500793 1.5176711142531283 0.7565068443247362 1.5396121941212475 0.783452263709478 0.18334795383888816 0.24346711216831815 1.1078378419648047 0.09512085407457177 0.22361571423125431 1.6420421861327555e-07 6.784615689500793 0.7831053497965113 AFSLAK(ub)NSQPNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFSLAKNSQPNR 12 1 P50750;P50750-2 P50750 CDK9 Cyclin-dependent kinase 9 1 17640200.0 878600.0 1096900.0 15664700.0 True False 850709.3239213245 1534897.890257935 11561645.139073176 1.0 1.804256574011508 13.59059412418339 19.69830674080939 -6.9207121376347045 0.8194321675134643 0.7465584563164218 15.522705160832569 0.9943763774956654 0.4315775160013341 0.09775452716363724 0.10345769069902881 0.3732570976866719 1.1258010053092966 1.2002946279355754e-07 6.9207121376347045 14.776146704516147 up AFSLAK(ub)NSQPNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFSLAKNSQPNR 12 1 P50750;P50750-2 P50750 CDK9 Cyclin-dependent kinase 9 1 42413100.0 1940600.0 5480600.0 34991900.0 True False 2944032.0768636493 4502544.109876756 28075735.627505414 1.0 1.5293801128258862 9.536491075673059 21.489361959768015 -6.920323772447305 0.8223223906991489 0.8253808210539948 10.83737265311849 0.9942703501083172 0.2956132391617836 0.09798175592117021 0.10463012513561785 0.255138210164823 0.7666412411735483 1.2013684641383521e-07 6.920323772447305 10.011991832064494 up AFSLAK(ub)NSQPNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFSLAKNSQPNR 12 1 P50750;P50750-2 P50750 CDK9 Cyclin-dependent kinase 9 1 9148010.0 1293300.0 1118900.0 6735810.0 True False 1771467.9601183475 1069463.2982924974 5144950.406361493 1.0 0.6037158573396095 2.9043429077982146 20.756513941528137 -6.862513075730916 1.1730722974991517 0.7834101690760648 3.0211646434668875 0.9566168873820625 0.2091688736367212 0.14422964382247175 0.3757366886545104 0.13893079957658575 0.32525703511015336 1.3724196395982166e-07 6.862513075730916 2.237754474390823 up AFSLAK(ub)NSQPNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFSLAKNSQPNR 12 1 P50750;P50750-2 P50750 CDK9 Cyclin-dependent kinase 9 1 17421800.0 878600.0 2432200.0 14111000.0 True False 730594.8285795226 2419097.255846099 17061544.8581077 1.0 3.3111338339876975 23.352950487317354 19.478712016243666 -6.928627089640205 0.7579746649132926 0.6791954661717898 27.32721107603087 0.996261510517553 0.6136934467245815 0.09335697816092452 0.08121811444106164 0.5546051900812815 1.82732061818523 1.1786175683618518e-07 6.928627089640205 26.64801560985908 AFSLAK(ub)NSQPNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFSLAKNSQPNR 12 1 P50750;P50750-2 P50750 CDK9 Cyclin-dependent kinase 9 1 57748200.0 1940600.0 3896600.0 51911000.0 True False 2512144.9549448765 3679750.784613315 42463730.651839875 1.0 1.4647844175433178 16.903375964931787 21.260488281860464 -6.913327083931935 0.8727678035741884 0.5708091794840978 19.04736408596472 0.9921178012180967 0.6560801652819601 0.10225887941342772 0.12713607418875156 0.546139137456289 1.5447243907230221 1.220879822122886e-07 6.913327083931935 18.476554906480622 up AFSQFGK(ub)LER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFSQFGKLER 10 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 193696900.0 60649000.0 85323000.0 47724900.0 True False 79511426.32575153 72593140.9864491 42786785.15756682 1.0 0.9129900486131539 0.5381212126955567 26.244658864469653 -6.943172155180999 0.6293598147320635 1.0040892095349228 0.42684078677920545 0.9985505801940538 0.00762934842617084 0.08634879757253575 0.048239859889340916 0.0076190232310944525 0.03184091226376845 1.1397978798924167e-07 6.943172155180999 -0.5772484227557173 AFSQFGK(ub)LER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFSQFGKLER 10 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 188602200.0 70997000.0 69576000.0 48029200.0 True False 68743239.09679292 97358059.63404684 35448911.674885206 1.0 1.416256506286578 0.515671244774659 26.034714495537468 -6.781026512015936 1.5318911689081165 1.2353799360847166 0.5083081602203602 0.7710021484329153 0.17610758692700826 0.24898091686798526 1.1541339978027314 0.09054002831185584 0.21345207753873932 1.655668888135583e-07 6.781026512015936 -0.7270717758643565 AFSQFGK(ub)LER ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFSQFGKLER 10 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 195053000.0 62508000.0 85447000.0 47098000.0 True False 94829205.94692013 70198315.24954176 37789059.65621324 1.0 0.7402604983198393 0.3984960042517424 26.498828119807744 -6.967342944238963 0.3152609237656277 1.0494852695647032 0.0783241070128194 0.9999536161275022 0.0016775894167213653 0.07717463628294861 0.012101811434900434 0.005283727045953818 0.030191481564957618 1.0780950593091998e-07 6.967342944238963 -0.9711611625518838 down AFSQFGK(ub)LER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFSQFGKLER 10 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 182908800.0 60649000.0 73732000.0 48527800.0 True False 83072574.2775982 70474276.4408816 37066533.10141312 1.0 0.8483458837495791 0.44619458857203953 26.307868925992544 -6.954186656141325 0.510818156587866 1.0073517456256635 0.26952111624371855 0.9994901975689438 0.0052760401288180145 0.08184688981706142 0.029332443463255028 0.006068418100227276 0.03319235010143952 1.1112540169351107e-07 6.954186656141325 -0.737830629381945 down AFSQFGK(ub)LER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFSQFGKLER 10 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 188869200.0 70997000.0 91757000.0 26115200.0 True False 59037151.20038738 91262686.82866143 31575767.576957986 1.0 1.545851806414104 0.5348457189233548 25.815119770971744 -6.760075443562903 1.612340198527372 1.317029444077085 0.5311564304405696 0.691241666835559 0.22958745514104906 0.28277771788258094 1.4488957853392643 0.11235286351438847 0.26996492404052624 1.737498972509623e-07 6.760075443562903 -0.7858730136365155 AFSQFGK(ub)LER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFSQFGKLER 10 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 219788000.0 62508000.0 134019000.0 23261000.0 True False 80917838.21688884 126560724.83783096 19027736.678015217 1.0 1.5640645823804982 0.23514885094945387 26.269954441900193 -6.791372338964542 1.4908064512524148 1.3146876076022687 0.2204660343441762 0.8057703935435971 0.24000796130906232 0.23330056841585883 1.02429544426488 0.12670926592514778 0.29636861053994934 1.6166933839291365e-07 6.791372338964542 -1.0942215732580924 down AFSQFVRPLIAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFSQFVRPLIAAK 13 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y8B3;F5H6N4 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 0 5715190.0 1418900.0 977190.0 3319100.0 False True 1373857.796166592 1367387.0629785312 2449728.139134345 1.0 0.9952900997424072 1.7831016761485077 20.38980125224113 -6.90555434313042 0.9254869340060325 0.9720471282320339 1.8757927335836415 0.9891326313391836 0.03859970646686684 0.10743184322132111 0.1552609987864711 0.030923194872071704 0.08294746735469125 1.2429270990410242e-07 6.90555434313042 0.9037456053516076 AFSQFVRPLIAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFSQFVRPLIAAK 13 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y8B3;F5H6N4 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 0 2223560.0 1418900.0 804660.0 0.0 False True 1179878.2179279362 800325.1368674951 0.0 1.0 0.6783116466655348 0.0 20.170206527675408 -7.473091449514057 0.7267820954759977 0.9922823238924797 3.066405449156539e-17 0.9871466286407121 0.04725510406479001 0.11777271597203776 0.14135447503102982 0.0414932428665603 0.07495741176620815 3.3644071749738123e-08 7.473091449514057 -0.9922823238924797 down AFSVFLFNTENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFSVFLFNTENK 12 0 Q13907;Q13907-2;C9JD53 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 0 80991000.0 26554000.0 29513000.0 24924000.0 False True 34812551.14930179 25109775.440772988 22345103.567890022 1.0 0.721285128834248 0.6418691773566897 25.053104206385278 -13.999999999999998 0.17608526905548041 2.429356447102781 0.5761681430483849 0.9995033848782876 0.0034222239491432122 12.156558094510489 0.13298132519468536 5.940153399748497 0.06132791647240149 1.0000000000000041e-14 13.999999999999998 -1.853188304054396 AFSVFLFNTENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFSVFLFNTENK 12 0 Q13907;Q13907-2;C9JD53 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 0 91733000.0 33259000.0 27617000.0 30857000.0 False True 32203211.250056174 38644612.12075245 22774626.009842616 1.0 1.2000235572992752 0.7072159926225646 24.94070122284749 -6.796524611562549 1.470046641747457 1.1108565373721027 0.7009832997469289 0.8217801381835426 0.08543371144411115 0.22577555537107558 0.963571503128302 0.04572741759034751 0.10657878398218451 1.5976269886249968e-07 6.796524611562549 -0.4098732376251738 AFSVFLFNTENK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFSVFLFNTENK 12 0 Q13907;Q13907-2;C9JD53 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 0 131801000.0 37536000.0 47771000.0 46494000.0 False True 56944856.2491775 39245891.813473426 37304440.520955905 1.0 0.6891911649006979 0.6550976326592224 25.76306219536439 -13.999999999999998 0.3120768371297804 4.041163695245559 0.6477141562565556 0.9996765508224006 0.002790824237339938 17.419166419758003 0.17782866664381178 34.438954595252085 0.011715109208897217 1.0000000000000041e-14 13.999999999999998 -3.393449538989003 AFSVFLFNTENK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFSVFLFNTENK 12 0 Q13907;Q13907-2;C9JD53 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 0 131257000.0 26554000.0 37304000.0 67399000.0 False True 36371731.39486785 35655785.93216843 51480744.32597687 1.0 0.9803158817234517 1.415405380818383 25.11631426790817 -6.896305391374902 0.9843445146823778 0.9800314703068819 1.4577958512168576 0.9846362924614225 0.024867499948378342 0.11417577471857639 0.19316050743314733 0.019071521339505588 0.048761321865695616 1.2696809647373037e-07 6.896305391374902 0.47776438090997575 AFSVFLFNTENK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFSVFLFNTENK 12 0 Q13907;Q13907-2;C9JD53 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 0 72789000.0 33259000.0 19246000.0 20284000.0 False True 27656332.123521924 19142317.97796811 24525290.61738054 1.0 0.6921495552075548 0.8867875359553407 24.721106498281767 -10.368289849984501 6.000493794573121 1.000034099084495 0.7894685465294361 0.6093711285347094 0.0794606228996224 3.625392702334448e-05 3.816711731861569e-06 0.07694986084753445 0.025645805764125337 4.28262600714707e-11 10.368289849984501 -0.21056555255505882 AFSVFLFNTENK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFSVFLFNTENK 12 0 Q13907;Q13907-2;C9JD53 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 0 127309000.0 37536000.0 53549000.0 36224000.0 False True 48591091.94517716 50568951.076645814 29631603.689627413 1.0 1.0407041507463997 0.6098155547329381 25.53418851745684 -6.883757051866957 1.0586487860764893 1.0267342792039709 0.576993668903689 0.9765907461891037 0.02971901678956804 0.12435302214440498 0.25262999656876145 0.021546977505748098 0.05263971602208046 1.3069017759684898e-07 6.883757051866957 -0.4497406103002819 AFSVNIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFSVNIFK 8 0 P11279;P11279-2 P11279 LAMP1 Lysosome-associated membrane glycoprotein 1 0 33833000.0 11087000.0 12323000.0 10423000.0 False True 14535164.36666072 10484456.434677776 9344527.94447592 1.0 0.7213166752159993 0.6428911093643666 23.79304405007341 -13.999999998813971 0.17785978539369715 2.43665340939018 0.579197503479019 0.9995008746888522 0.0034235411204482165 12.177816786350851 0.13367158185616795 6.043244478616137 0.05963817436525129 1.0000000027309328e-14 13.999999998813971 -1.857455905911161 AFSVNIFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFSVNIFK 8 0 P11279;P11279-2 P11279 LAMP1 Lysosome-associated membrane glycoprotein 1 0 27072800.0 8792900.0 5519900.0 12760000.0 False True 8513774.202490121 7724024.855898221 9417773.208205322 1.0 0.9072386314449221 1.106180758875517 23.02136739760829 -6.7799114666547835 1.5360937960577963 0.947468927624047 1.1077551703359863 0.7670839125378978 0.03922653643341729 0.2507305931503091 1.168539942423224 0.020112631213733478 0.04746328508831463 1.65992525794363e-07 6.7799114666547835 0.16028624271193925 AFSVNIFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFSVNIFK 8 0 P11279;P11279-2 P11279 LAMP1 Lysosome-associated membrane glycoprotein 1 0 18224500.0 8792900.0 4085300.0 5346300.0 False True 7311685.941517062 4063291.678031441 6464186.611501762 1.0 0.5557256849558244 0.8840897521044979 22.801772673042567 -9.858880783186992 6.897678837756699 1.0000000037690107 0.7199077185301568 0.4924191845576211 0.1340540690632243 7.847261810366067e-09 1.1216123617935567e-09 0.129797296177424 0.04326576474776468 1.3839462295625963e-10 9.858880783186992 -0.2800922852388539 AFTGEGQK(ub)LGSTAPQVLSTSSPAQQAENEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFTGEGQKLGSTAPQVLSTSSPAQQAENEAK 31 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 21563100.0 6705700.0 9835400.0 5022000.0 True False 8791237.638091177 8367996.658088918 4502371.614425601 1.0 0.9518564964996036 0.512143090628954 23.067634852855097 -6.927719347328976 0.765291247851081 1.0072832116244455 0.42690347958751346 0.9960704486263856 0.013760363381625281 0.09383988498295821 0.08361257838036486 0.012370210216985986 0.04029711603030232 1.181083636819127e-07 6.927719347328976 -0.5803797320369319 AFTGEGQK(ub)LGSTAPQVLSTSSPAQQAENEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFTGEGQKLGSTAPQVLSTSSPAQQAENEAK 31 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 30475400.0 10432000.0 11154000.0 8889400.0 True False 10100841.870188097 15607850.367341585 6560999.463716324 1.0 1.545202921491824 0.6495497650627161 23.26797220583507 -6.741962363026424 1.679637297648726 1.3236605616695232 0.6488119795580006 0.6136396926608718 0.22906361781766119 0.3142911906812356 1.7417426757241192 0.10785776850756182 0.26409244538606785 1.8114970743823473e-07 6.741962363026424 -0.6748485821115225 AFTGEGQK(ub)LGSTAPQVLSTSSPAQQAENEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFTGEGQKLGSTAPQVLSTSSPAQQAENEAK 31 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 59263000.0 13844000.0 26409000.0 19010000.0 True False 21002360.13196968 21696107.61554124 15252665.167621003 1.0 1.0330318820938387 0.7262357693030641 24.32404812350133 -6.880244259704486 1.0783958169372558 1.0205412675513534 0.7043877173879352 0.9738836448778686 0.022221126264690808 0.12741577927787776 0.27095845422976533 0.01586910353085164 0.038400763951249785 1.3175155215214294e-07 6.880244259704486 -0.3161535501634183 AFTGEGQK(ub)LGSTAPQVLSTSSPAQQAENEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFTGEGQKLGSTAPQVLSTSSPAQQAENEAK 31 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 24615200.0 6705700.0 12455000.0 5454500.0 True False 9184978.504728684 11904696.916822815 4166259.4389537093 1.0 1.2961050383181565 0.45359490354918114 23.130844914377988 -6.811754953761905 1.40734873007641 1.1610409689730106 0.43828488172642327 0.8643102530552912 0.1285492169502198 0.20441849715580812 0.7976719777196591 0.07181879234296253 0.16598745883427232 1.5425705871869187e-07 6.811754953761905 -0.7227560872465872 down AFTGEGQK(ub)LGSTAPQVLSTSSPAQQAENEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFTGEGQKLGSTAPQVLSTSSPAQQAENEAK 31 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 28066600.0 10432000.0 13390000.0 4244600.0 True False 8674670.215959005 13317865.412293112 5132126.235187017 1.0 1.5352589874589013 0.5916220567953486 23.048377481269345 -6.752839223988913 1.6392848576313401 1.3136715122475744 0.5893339457243633 0.6610448923470869 0.22495989330246602 0.2951574486843468 1.5613684668193024 0.10836561795775375 0.26230842489231715 1.7666917297070518e-07 6.752839223988913 -0.7243375665232111 AFTGEGQK(ub)LGSTAPQVLSTSSPAQQAENEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFTGEGQKLGSTAPQVLSTSSPAQQAENEAK 31 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 68673000.0 13844000.0 27635000.0 27194000.0 True False 17921330.906037755 26097087.956882633 22244971.03400308 1.0 1.4562025607199987 1.2412566427479264 24.09517444559378 -10.15862951788282 4.581984194332901 0.999951321074911 1.3487296017393289 0.7782509765531879 0.08775130357259332 61437068.683345646 3.14724161743575 31553.10876624246 0.03003960525800918 6.940175967940101e-11 10.15862951788282 0.34877828066441785 AFTHTAQYDEAISDYFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFTHTAQYDEAISDYFR 17 0 P31939-2;P31939;C9JLK0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 22931400.0 6520000.0 10183000.0 6228400.0 False True 8547783.13976981 8663736.093023121 5583944.915031547 1.0 1.013565266146473 0.6532623516209047 23.0271188761114 -6.898151952780583 0.9728927878143369 1.015749105863883 0.6168324286459512 0.9856237666657501 0.01999264620461176 0.11277787530409612 0.18519798167228754 0.015464614789500961 0.03987521957519415 1.2642939136014606e-07 6.898151952780583 -0.3989166772179318 AFTHTAQYDEAISDYFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFTHTAQYDEAISDYFR 17 0 P31939-2;P31939;C9JLK0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 65491000.0 10619000.0 44394000.0 10478000.0 False True 16109799.35288834 36471543.84809486 8407018.707329458 1.0 2.263935325895654 0.5218574436075863 23.941435189640522 -6.712109064063791 1.7877347295670907 1.7753551007099873 0.5256965940930859 0.4751168272237932 0.5324420561307438 0.37083919831371803 2.3116346489200654 0.23689872720638658 0.6002891779271066 1.940398525502039e-07 6.712109064063791 -1.2496585066169015 AFTHTAQYDEAISDYFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFTHTAQYDEAISDYFR 17 0 P31939-2;P31939;C9JLK0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 25240800.0 6520000.0 8636800.0 10084000.0 False True 8930620.196374869 8255197.617921738 7702366.886499075 1.0 0.9243700254180219 0.8624671878472261 23.09032893763429 -6.973412934285217 0.1564737698706742 1.065766153785896 0.7194337544799799 0.9999982355754099 7.448199077395544e-05 0.07521009283743559 0.004813099519976534 0.00296419653680537 0.007527386329297795 1.0631316945333673e-07 6.973412934285217 -0.3463323993059161 AFTHTAQYDEAISDYFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFTHTAQYDEAISDYFR 17 0 P31939-2;P31939;C9JLK0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 32731500.0 10619000.0 14871000.0 7241500.0 False True 13746504.831783809 14043415.777340382 5923621.304064618 1.0 1.0215990136540072 0.4309183589975826 23.71256151173297 -6.898409794864014 0.9712403647884977 1.0256413122428494 0.3708749299338626 0.985759191052059 0.032638176395609404 0.11258619013651418 0.18408342186447227 0.025276536079448138 0.06525773204381219 1.2635435208625575e-07 6.898409794864014 -0.6547663823089868 down AFTK(ub)PEEACSFILSADFPALVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFTKPEEACSFILSADFPALVVK 23 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;H7C366 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 56949100.0 7722100.0 14035000.0 35192000.0 True False 11714990.261129953 11530344.594044492 28236285.77479842 1.0 0.9842385129676027 2.4102696754674833 23.481852419076233 -6.904400793518574 0.9330187636246506 0.9476550256751219 2.5740903676600126 0.9886316392439437 0.07128285389136857 0.1082383019500724 0.1597107122069315 0.05679053195899042 0.1513057627240539 1.246232883437448e-07 6.904400793518574 1.6264353419848907 up AFTKPEEACSFILSADFPALVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFTKPEEACSFILSADFPALVVK 23 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;H7C366 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 142372000.0 29942000.0 77417000.0 35013000.0 False True 45424203.05341204 63601331.48821815 28092665.203256935 1.0 1.4001639481364712 0.6184514711292607 25.436957867477176 -6.7675338413003026 1.5837238635305777 1.2302413903877654 0.6144398659307022 0.7211199623258724 0.16854705793002728 0.2704256679560058 1.338190319845275 0.08390284124841083 0.20019265224876018 1.70791462994175e-07 6.7675338413003026 -0.6158015244570632 AFTKPEEACSFILSADFPALVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFTKPEEACSFILSADFPALVVK 23 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;H7C366 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 74426000.0 29942000.0 21900000.0 22584000.0 False True 38760509.24505797 20681245.748352822 18473943.731408603 1.0 0.5335648615346744 0.4766176732769336 25.208084189569625 -13.999999999999998 0.2966298575461698 5.173310275537772 0.46211054183217426 0.9996423018565044 0.004434273771711444 16.372070035061054 0.17287400909905404 41.85461461179957 0.020883125354855026 1.0000000000000041e-14 13.999999999999998 -4.711199733705598 AFTTTLNLLPYHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFTTTLNLLPYHK 13 0 O43847-2;G3V1R5;O43847;H0Y5G9 O43847-2 NRD1 Nardilysin 0 32901800.0 13097000.0 11566000.0 8238800.0 False True 17170293.831528433 9840397.883914893 7386328.008150074 1.0 0.5731059689756596 0.4301806410899709 24.03341139229135 -13.999999999999998 0.1528539726877411 3.073811000855694 0.2779795314525962 0.9995569944036383 0.0050949130269148935 11.969568799253402 0.12326946539772017 7.367172567759511 0.13757998010239736 1.0000000000000041e-14 13.999999999999998 -2.7958314694030975 AFTTTLNLLPYHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFTTTLNLLPYHK 13 0 O43847-2;G3V1R5;O43847;H0Y5G9 O43847-2 NRD1 Nardilysin 0 27683200.0 12476000.0 6613300.0 8593900.0 False True 12079956.209017128 9254025.177903906 6342899.77852631 1.0 0.7660644639585865 0.5250763884219737 23.526111888978143 -6.970753498134093 0.2395161933428611 1.0870528465721594 0.19712204736701272 0.9999876745552969 0.0006806906344845549 0.07605900475092399 0.00815071829200985 0.00578030018486809 0.023514137610023203 1.0696618379444953e-07 6.970753498134093 -0.8899307992051466 AFTTTLNLLPYHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFTTTLNLLPYHK 13 0 O43847-2;G3V1R5;O43847;H0Y5G9 O43847-2 NRD1 Nardilysin 0 55100000.0 13004000.0 18253000.0 23843000.0 False True 19728018.71974385 14995609.538660085 19130420.59924184 1.0 0.76011736159052 0.9697081532113545 24.23374273802624 -10.212476058989397 6.792879360901617 1.000000604031036 0.8649127574984444 0.356453532679481 0.08556508237617348 7.827957835093758e-07 9.068863488092972e-08 0.08284840635309061 0.02761601158831546 6.130895885262143e-11 10.212476058989397 -0.13508784653259165 AFTTTLNLLPYHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFTTTLNLLPYHK 13 0 O43847-2;G3V1R5;O43847;H0Y5G9 O43847-2 NRD1 Nardilysin 0 47339000.0 13097000.0 15309000.0 18933000.0 False True 17939314.833116848 14632597.7599069 14461415.337374752 1.0 0.8156720530315021 0.8061297475351888 24.09662145381424 AFTTTLNLLPYHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFTTTLNLLPYHK 13 0 O43847-2;G3V1R5;O43847;H0Y5G9 O43847-2 NRD1 Nardilysin 0 26484200.0 12476000.0 6393500.0 7614700.0 False True 10374346.780512324 6359056.946489609 9206898.563605178 1.0 0.6129597439748948 0.8874677855284212 23.30651716441242 -10.121837806045303 5.796320657714498 1.00000202982612 0.7502137647516436 0.5247128329142556 0.11206743868286147 2.9396654906869865e-06 4.452180326562577e-07 0.10850971367355265 0.03616961030589616 7.55374281138206e-11 10.121837806045303 -0.2497882650744765 AFTTTLNLLPYHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFTTTLNLLPYHK 13 0 O43847-2;G3V1R5;O43847;H0Y5G9 O43847-2 NRD1 Nardilysin 0 57737000.0 13004000.0 24978000.0 19755000.0 False True 16833934.347162317 23587952.342573375 16159792.703417344 1.0 1.4012144669287947 0.959953411374768 24.00486906011869 -6.667411303244753 1.9469530169154396 1.2566682582997009 0.9617716735743405 0.26746309114122446 0.17053077857801988 0.4670861345164582 3.411038865062172 0.07058325600682643 0.18919187113800132 2.1507438848406389e-07 6.667411303244753 -0.2948965847253604 AFTVSMK(ub)GSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFTVSMKGSR 10 1 O15118;K7EQ23;O15118-2;K7ERM4;K7ERW2 O15118 NPC1 Niemann-Pick C1 protein 1 12341600.0 475760.0 628840.0 11237000.0 True False 460657.2592178572 879939.0913572791 8293692.597225944 1.0 1.9101817538951062 18.004041901581395 18.81333422220547 -6.918542260618364 0.8354637986888628 0.6258982309647784 20.514280705825286 0.9937663632518686 0.6166333973209724 0.09903725280415168 0.11011375335152039 0.527231414241347 1.5579637704495979 1.2063066983853015e-07 6.918542260618364 19.888382474860506 up AFTVSMK(ub)GSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFTVSMKGSR 10 1 O15118;K7EQ23;O15118-2;K7ERM4;K7ERW2 O15118 NPC1 Niemann-Pick C1 protein 1 13634280.0 475760.0 886220.0 12272300.0 True False 395615.51974162715 881445.7569591023 14838381.189295962 1.0 2.228036345830837 37.50707555402976 18.593739497639746 -6.914284879951641 0.866041749548762 0.050117086772963115 42.51031023226474 0.9924408462392939 1.471740847777666 0.1016518239724186 0.12389995547651828 1.2310742593301447 3.50822920219405 1.21819025230386e-07 6.914284879951641 42.46019314549178 up AFVAGVLPFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFVAGVLPFK 10 0 O00442-2;O00442 O00442-2 RTCA RNA 3-terminal phosphate cyclase 0 4305500.0 1255500.0 1364400.0 1685600.0 False True 1645972.6582792941 1160836.838389544 1511190.281416925 1.0 0.7052588829774895 0.9181138421805431 20.65050894026446 -10.254357891187647 5.827375995896325 1.0000085063747652 0.8116863633778776 0.5106678308092956 0.08689767321140758 9.603877538633354e-06 1.228938839247602e-06 0.08414211009672519 0.02804610343099552 5.56726775274338e-11 10.254357891187647 -0.18832214299688765 AFVAGVLPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFVAGVLPFK 10 0 O00442-2;O00442 O00442-2 RTCA RNA 3-terminal phosphate cyclase 0 3818240.0 1177800.0 429440.0 2211000.0 False True 1140411.3836951253 600917.6315000156 1631872.7714217836 1.0 0.5269305796939181 1.4309509662506528 20.121122914903957 -6.764514084383164 1.595535426793275 0.7267628512893206 1.4350053745348994 0.7091106125196106 0.19912399513730647 0.27539320815886903 1.3826886582857458 0.09842513857115517 0.2354836589683045 1.7198315653522116e-07 6.764514084383164 0.7082425232455788 AFVAGVLPFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFVAGVLPFK 10 0 O00442-2;O00442 O00442-2 RTCA RNA 3-terminal phosphate cyclase 0 4341800.0 1255500.0 1535300.0 1551000.0 False True 1719692.2786117562 1467465.369441836 1184685.743847687 1.0 0.8533302077895392 0.6888940298109845 20.71371900178735 -6.969644392843021 0.2665495400252898 1.042625856469924 0.49467764027086336 0.9999794702447631 0.00057575630154291 0.07641831077355533 0.009442586932925079 0.0032928046604107732 0.015367340983746093 1.0723970414120286e-07 6.969644392843021 -0.5479482161990606 AFVAIGDYNGHVGLGVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFVAIGDYNGHVGLGVK 17 0 P15880;H0YEN5;E9PMM9;E9PPT0;I3L404;E9PM36 P15880 RPS2 40S ribosomal protein S2 0 198729000.0 0.0 111104600.0 87624400.0 False True 0.0 91277116.06579809 70305398.93286106 0.0 AFVAIGDYNGHVGLGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFVAIGDYNGHVGLGVK 17 0 P15880;H0YEN5;E9PMM9;E9PPT0;I3L404;E9PM36 P15880 RPS2 40S ribosomal protein S2 0 142847200.0 0.0 86229200.0 56618000.0 False True 0.0 81430469.21844128 46314104.949738406 0.0 AFVDFLSDEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFVDFLSDEIK 11 0 Q07021 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 13074600.0 1714200.0 5519200.0 5841200.0 False True 2247332.800336413 4695756.873673096 5236808.656746887 1.0 2.089479970643497 2.330232823533286 21.099782353763125 -10.542459006522108 0.31410986298607724 2.3781442610899546e-24 2.396283663929883 0.9991045340603516 0.017318375367098827 2.1119433845892552 0.1521856344153194 1.747375846755994 0.08147643126469202 2.8677480523299343e-11 10.542459006522108 2.396283663929883 AFVDFLSDEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFVDFLSDEIK 11 0 Q07021 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 16659300.0 7351700.0 3548100.0 5759500.0 False True 7118324.307617132 4964874.833097069 4250914.168703645 1.0 0.6974780325454246 0.5971790529626267 22.76310623219894 -13.999999999590473 0.15427864462198376 2.473297968148155 0.4920798187360563 0.9995525915951187 0.003621629262065105 11.976372074647683 0.12390650073208727 5.2840622382136315 0.09514777502412969 1.00000000094297e-14 13.999999999590473 -1.9812181494120988 AFVDFLSDEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFVDFLSDEIK 11 0 Q07021 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 15910800.0 1714200.0 7613200.0 6583400.0 False True 2347986.064513161 7276823.650514284 5028536.509379017 1.0 3.0991766776192877 2.1416381406086624 21.162992415286016 -9.88697737315326 7.603639175811479 0.9999999949425112 2.6204074091139757 0.7924596653092527 0.39091347078785915 3.70797000839864e-08 5.934100274068745e-09 0.37850034336242194 0.12616678018079275 1.2972468560958907e-10 9.88697737315326 1.6204074141714644 AFVDFLSDEIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFVDFLSDEIK 11 0 Q07021 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 12003900.0 7351700.0 2334100.0 2318100.0 False True 6113264.285531624 2321525.740017427 2802803.992316597 1.0 0.37975222918332274 0.4584791138426724 22.543511507633216 -10.60173133599519 6.497510471837849 1.0015008415518054 0.419115671513962 0.9864110463655211 0.03214011607572523 0.0007002162255630545 4.292012774741855e-05 0.03118416725511926 0.010373177858871428 2.501892608206747e-11 10.60173133599519 -0.5823851700378434 AFVDFLSDEIKEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFVDFLSDEIKEER 14 1 Q07021 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 10634220.0 699520.0 6935000.0 2999700.0 False True 917077.4941613163 5900325.0324182715 2689319.819154219 1.0 6.433834730416347 2.932489169427988 19.80668412289014 -9.314043609502333 9.897393208968436 0.9999928228207297 4.683161949922217 0.5960252386415886 1.4294183396028874 0.0 0.0 1.3840283560085795 0.46134278533619305 4.852397725628749e-10 9.314043609502333 3.683169127101487 AFVDFLSDEIKEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFVDFLSDEIKEER 14 1 Q07021 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 15072300.0 7034400.0 2804800.0 5233100.0 False True 6811096.822435892 3924771.2668387764 3862394.1203651475 1.0 0.576231900552419 0.5670737358544577 22.699455710127328 AFVDFLSDEIKEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFVDFLSDEIKEER 14 1 Q07021 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 11756320.0 699520.0 4990500.0 6066300.0 False True 958151.4478172015 4770003.208623385 4633564.879370224 1.0 4.978339509364722 4.835942052716312 19.86989418441303 -10.176621983179123 4.633121664239567 0.9994015215591636 4.907140781078925 0.9990047889603239 0.05813351837442446 0.0003594170715649729 6.38742300467245e-05 0.056293791903929705 0.018762512358172254 6.658524726190497e-11 10.176621983179123 3.9077392595197615 AFVDFLSDEIKEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFVDFLSDEIKEER 14 1 Q07021 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 9245400.0 7034400.0 1114900.0 1096100.0 False True 5849415.2767582545 1108893.8124096768 1325289.442206214 1.0 0.18957344622388064 0.2265678498621984 22.479860985561604 -10.701612758213146 6.761616768936452 1.0076051233461254 0.20807064804303954 0.9983660066156103 0.015102902042073344 0.001723906945688253 7.607519397981589e-05 0.014559309927200774 0.004874440674029336 1.9878666228819592e-11 10.701612758213146 -0.7995344753030859 AFVGNQLPFIGFTYYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFVGNQLPFIGFTYYR 16 0 D6REE7;E9PF63;O75116 D6REE7 ROCK2 Rho-associated protein kinase 2 0 26007900.0 9716900.0 6472900.0 9818100.0 False True 14741247.700544376 5317760.422001469 7877548.231573901 1.0 0.36074018495768784 0.5343881597812777 23.81335530365181 -10.751314780014367 10.517265176627626 1.0013390396359056 0.44756417237013313 0.9310092251016923 0.0708914888642425 0.0022288834069532277 5.2702846584904486e-05 0.06873446912983898 0.022880129646588313 1.7729040004907205e-11 10.751314780014367 -0.5537748672657725 AFVGNQLPFVGFTYYSNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFVGNQLPFVGFTYYSNR 18 0 Q13464;A0A0U1RQV4 Q13464 ROCK1 Rho-associated protein kinase 1 0 6548000.0 2829500.0 1344100.0 2374400.0 False True 2739679.0712899975 1880806.139388902 1752473.4095268594 1.0 0.6865060068890884 0.6396637576611098 21.38557547368676 -13.999999999999998 0.26767725991832797 3.3897676832572294 0.6237617252176417 0.9995783576866297 0.0032848169596574814 14.770532346256156 0.16376249748777086 19.181767302657626 0.01968316226207956 1.0000000000000041e-14 13.999999999999998 -2.766005958039588 AFVGNQLPFVGFTYYSNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFVGNQLPFVGFTYYSNR 18 0 Q13464;A0A0U1RQV4 Q13464 ROCK1 Rho-associated protein kinase 1 0 4774200.0 2829500.0 0.0 1944700.0 False True 2352854.618103531 0.0 2351327.7787231277 1.0 0.0 0.9993510693909197 21.165980749121037 -12.016131272864857 24.992409982456127 0.8733899566029275 0.5497079812259267 0.0 0.48549654084921684 0.0 0.0 0.0 0.13913876547195145 9.635377339984738e-13 12.016131272864857 -0.32368197537700083 AFVHWYVGEGMEEGEFSEAR ddPTM_RPMI8226_Bortezomib_2h_R1 2 AFVHWYVGEGMEEGEFSEAR 20 0 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 33032900.0 11646200.0 4903900.0 16482800.0 False True 11276497.75580759 6862052.843500672 12165460.206599267 1.0 0.6085269550970821 1.0788332042485307 23.426815730629627 -6.685775218648722 1.8812967920166597 0.7536057507388573 1.0771349845037383 0.35075002415575207 0.1657104106865455 0.4258344238385463 2.918628657523245 0.07055125503263282 0.18471366674608802 2.0616967264237544e-07 6.685775218648722 0.3235292337648811 AFVHWYVGEGMEEGEFSEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFVHWYVGEGMEEGEFSEAR 20 0 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 141129900.0 29756900.0 62262000.0 49111000.0 False True 45143392.82078943 51150859.64477361 39404189.323883995 1.0 1.133075217625593 0.8728672539148982 25.428011514770187 -6.76768663362257 1.5833429075519025 1.0765532935310391 0.8715309053439537 0.7216323397354323 0.05605212660941857 0.2701810227896631 1.336394565350163 0.0279102377411973 0.06657903263147234 1.7073138616742852e-07 6.76768663362257 -0.2050223881870854 AFVHWYVGEGMEEGEFSEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AFVHWYVGEGMEEGEFSEAR 20 0 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 25521400.0 11646200.0 6521100.0 7354100.0 False True 9684331.314139372 6485969.539962988 8891808.308483446 1.0 0.6697385012523587 0.9181644059927171 23.207221006063904 -9.754695586418284 5.519745473499913 1.0000000275553653 0.793951453617609 0.47841752240037916 0.10141945093454466 136366205.48145562 66.13685267856766 47.703435591747535 0.034718575651468686 1.7591562416765328e-10 9.754695586418284 -0.20604857393775633 AFVHWYVGEGMEEGEFSEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFVHWYVGEGMEEGEFSEAR 20 0 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 88233800.0 29756900.0 40041900.0 18435000.0 False True 38520893.6461915 37813533.06534103 15080019.159073574 1.0 0.9816369633750591 0.39147635819618404 25.199137836862636 -6.913534305406943 0.871320405342745 1.0162941866769353 0.3091483585084349 0.9921883113440976 0.02498007997071036 0.10212723771718962 0.1264332797590014 0.020815816147621045 0.05897055483918837 1.2202974242785244e-07 6.913534305406943 -0.7071458281685004 down AFVK(ub)MCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFVKMCK 7 1 P50502;Q8NFI4;Q3KNR6;Q8IZP2;F8WAQ7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 1 28397100.0 8064800.0 10969000.0 9363300.0 True False 10573030.899634285 9332467.956827123 8394475.535115743 1.0 0.8826672356693791 0.7939516695639377 23.33388566790194 -6.974217461757216 0.1204631104521334 1.158505368030439 0.5158333161037327 0.9999994338338907 6.323455386769186e-05 0.07495626466218078 0.0035885612697214454 0.006215845528937388 0.012753869599145049 1.0611640736141637e-07 6.974217461757216 -0.6426720519267062 AFVK(ub)MCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFVKMCK 7 1 P50502;Q8NFI4;Q3KNR6;Q8IZP2;F8WAQ7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 1 47537000.0 10419000.0 16899000.0 20219000.0 True False 10088254.548072262 23646858.82712083 14923037.343001842 1.0 2.3439990252465868 1.479248691821862 23.26617324770724 -10.106297084309887 4.828858199075914 0.9999637406835621 1.911623858538527 0.5970661106732447 0.3530328453526831 0.00016754408855044906 3.100823221065341e-05 0.341839032243102 0.11394086088500892 7.828939116511876e-11 10.106297084309887 0.9116601178549649 AFVK(ub)MCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFVKMCK 7 1 P50502;Q8NFI4;Q3KNR6;Q8IZP2;F8WAQ7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 1 38164200.0 9034200.0 12523000.0 16607000.0 True False 13705541.88848892 10288172.80735442 13324619.170893317 1.0 0.750657864611344 0.9722066649611618 23.708256034650343 -10.274909374500483 7.132970412875686 1.0000009324211914 0.8614322648948535 0.3427900964339621 0.09044691899713282 1.3411295139592788e-06 1.362985441685296e-07 0.0875754412709058 0.029191617582638905 5.309952369997192e-11 10.274909374500483 -0.1385686675263379 AFVK(ub)MCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFVKMCK 7 1 P50502;Q8NFI4;Q3KNR6;Q8IZP2;F8WAQ7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 1 31947800.0 8064800.0 12731000.0 11152000.0 True False 11046574.503025156 12168502.32421285 8518127.282649511 1.0 1.1015634141498298 0.7711102912777877 23.39709572942483 -6.824204460506221 1.3536876879752862 1.0545208952932157 0.7632306390066006 0.8937612157904237 0.045046847819384735 0.18807395986235179 0.6760353819582762 0.026142663583655773 0.060194742118694966 1.4989789684771513e-07 6.824204460506221 -0.2912902562866151 AFVK(ub)MCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFVKMCK 7 1 P50502;Q8NFI4;Q3KNR6;Q8IZP2;F8WAQ7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 1 40025000.0 10419000.0 17456000.0 12150000.0 True False 8663860.139961364 17361961.0632553 14690508.824747287 1.0 2.003952139436628 1.6956077992289473 23.046578523141516 -10.123274485406373 6.2626040177518805 0.9999972538658097 1.8497799693327925 0.910128317164107 0.1258810497640109 4.82650179816536e-06 6.758698466602231e-07 0.12188419625885515 0.04062793411159087 7.528795738612904e-11 10.123274485406373 0.8497827154669828 AFVK(ub)MCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFVKMCK 7 1 P50502;Q8NFI4;Q3KNR6;Q8IZP2;F8WAQ7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 1 25579400.0 9034200.0 11003000.0 5542200.0 True False 11694949.99070546 10390673.377585657 4533576.467774208 1.0 0.8884752295515266 0.38765248858500967 23.479382356742793 -6.942227764362959 0.638508811149374 1.0054774358295049 0.24326257733103296 0.9984412965355738 0.010513547092884346 0.08676502920822046 0.05009202523492939 0.010415899676021982 0.042699715417563545 1.1422791130173127e-07 6.942227764362959 -0.7622148584984719 down AFVSK(ub)SHPEFSSNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFVSKSHPEFSSNR 14 1 Q92995;Q92995-2;H7C5J3 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 27025300.0 3081100.0 5094200.0 18850000.0 True False 4674253.958582188 4185100.2088337373 15124289.237751499 1.0 0.8953514819513951 3.2356584327179037 22.156304689160326 -6.89643354722958 0.9835481309180156 0.8929502902161595 3.4642636419377255 0.9847065965005259 0.13348700444248504 0.11407802010750111 0.19259840299940853 0.1024352855174873 0.2620537298447916 1.269306350160612e-07 6.89643354722958 2.571313351721566 up AFVSMVYSEEGAEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFVSMVYSEEGAEDR 15 0 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 0 6246900.0 1436900.0 2056600.0 2753400.0 False True 1883789.8149593917 1749763.2965640107 2468504.5804777886 1.0 0.9288527216088223 1.3103927842029455 20.845206573642265 -6.858511734357659 1.1932012949727673 0.9615397133902601 1.328353237043151 0.9518082328551539 0.03636592872341503 0.14834410688617228 0.40216824957394703 0.023784668219688266 0.05543195210700112 1.3851227602924764e-07 6.858511734357659 0.3668135236528909 AFVYLSNLLYPVPLIHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFVYLSNLLYPVPLIHR 17 0 A0A087WWA3;Q4R9M9;O60333-2;O60333;O60333-4 A0A087WWA3 KIF1B;KIF1Bbeta Kinesin-like protein;Kinesin-like protein KIF1B 0 58945000.0 20713000.0 19181000.0 19051000.0 False True 31423135.32313554 15758000.688162968 15285561.499650087 1.0 0.5014776700707205 0.4864429135559865 24.90532380058741 AFVYLSNLLYPVPLIHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFVYLSNLLYPVPLIHR 17 0 A0A087WWA3;Q4R9M9;O60333-2;O60333;O60333-4 A0A087WWA3 KIF1B;KIF1Bbeta Kinesin-like protein;Kinesin-like protein KIF1B 0 41935100.0 20713000.0 11798000.0 9424100.0 False True 26813386.81427047 11141430.92872449 7709010.499431798 1.0 0.4155174803503323 0.2875060339385755 24.67645012267986 -13.999999999999998 0.21340856868386568 4.428530054068902 0.21455251968433042 0.9994921978499027 0.006988727945198975 12.828654945685903 0.14639760751086975 18.473082772099755 0.07405667740633094 1.0000000000000041e-14 13.999999999999998 -4.213977534384571 AFYAELYHIISSNLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFYAELYHIISSNLEK 16 0 A0A087X1Z3;Q9UL46;H0YM70 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 0 238776000.0 103810000.0 44816000.0 90150000.0 False True 100514608.37272115 62711262.51235261 66537010.55797099 1.0 0.6239019733311912 0.6619635855441347 26.58282995100359 -9.893033888646524 6.803330112405352 1.0000000105122175 0.6429327798171086 0.9915501229369047 0.015538588118251925 2.4814295825103504e-09 3.9543675181253706e-10 0.015045173699763686 0.005015057750460997 1.2792814760200493e-10 9.893033888646524 -0.35706723069510893 AFYAELYHIISSNLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFYAELYHIISSNLEK 16 0 A0A087X1Z3;Q9UL46;H0YM70 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 0 120256700.0 33275700.0 41226000.0 45755000.0 False True 50481669.67952786 33868898.19979184 36711504.19487109 1.0 0.6709147778748472 0.7272244445939737 25.58925629241112 -10.56028088732959 6.348095491221274 1.0004865048001539 0.6990696112344155 0.9744119199781269 0.022988325174673283 0.00015853285459431095 1.098121238373098e-05 0.022293205005067318 0.007419450046559189 2.752447935096318e-11 10.56028088732959 -0.3014168935657384 AFYAELYHIISSNLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFYAELYHIISSNLEK 16 0 A0A087X1Z3;Q9UL46;H0YM70 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 0 247591000.0 103810000.0 48161000.0 95620000.0 False True 86322614.56275931 47901547.13378995 115613699.90307261 1.0 0.5549130708843856 1.339321109406594 26.363235226437865 -6.752809572705264 1.639796655090963 0.739167625851576 1.3411873561137992 0.6608446041466445 0.18705863254570945 0.2951630448689875 1.5624337731322195 0.09008882394276156 0.21804003251877502 1.7668123540025303e-07 6.752809572705264 0.6020197302622232 AFYAELYHIISSNLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFYAELYHIISSNLEK 16 0 A0A087X1Z3;Q9UL46;H0YM70 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 0 84734900.0 33275700.0 26051000.0 25408200.0 False True 43076049.612109266 24601238.949330546 20784168.310147725 1.0 0.571111770249582 0.4824994050593026 25.36038261450357 -13.999999999999998 0.22165794973333983 3.607067787064148 0.4358469441607215 0.9994996077966747 0.0050550527389488275 13.045219580357502 0.14913462295387162 14.89973035300322 0.04850938422470025 1.0000000000000041e-14 13.999999999999998 -3.1712208429034265 AFYGLK(ub)QVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFYGLKQVEK 10 1 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 1 28701600.0 1147400.0 2453200.0 25101000.0 True False 1740689.686176105 2015407.2930609146 20139776.34784089 1.0 1.1578211263423415 11.569998092011074 20.73122760510049 -6.910197460224715 0.8943905005165989 0.6796284447804316 12.921289278604164 0.9909958400680896 0.469323938192611 0.1042875404867418 0.13806058327523868 0.38461731936709087 1.0631740294212977 1.2297095329213617e-07 6.910197460224715 12.241660833823731 up AFYPEEISSMVLTK ddPTM_RPMI8226_Bortezomib_1h_R1 2 AFYPEEISSMVLTK 14 0 P0DMV9;P0DMV8;A0A0G2JIW1;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 34392420.0 5404720.0 15033700.0 13954000.0 False True 7085640.2593829315 12790730.560903618 12510173.936219621 1.0 1.8051622849418447 1.765567186346135 22.756466790470657 -10.109810721067342 5.0475358971339634 0.9999751956100008 1.785364735579806 0.998097282745433 0.016164631321448342 4.588485168910989e-06 8.091997522255595e-07 0.01565183819829178 0.005217112324159554 7.765855028025865e-11 10.109810721067342 0.7853895399698051 AFYPEEISSMVLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFYPEEISSMVLTK 14 0 P0DMV9;P0DMV8;A0A0G2JIW1;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 26654000.0 9970600.0 4283400.0 12400000.0 False True 9654088.760630516 5993783.95763591 9152068.007973809 1.0 0.6208544489541705 0.947999157133923 23.202708660446113 -10.143536374200679 7.395147809205873 1.000000099981502 0.7844268030440468 0.3666716806968825 0.1335562678486833 2.2007822555311467e-07 2.5535810324277713e-08 0.12931536002492733 0.043105100096630634 7.185609730069308e-11 10.143536374200679 -0.2155732969374552 AFYPEEISSMVLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AFYPEEISSMVLTK 14 0 P0DMV9;P0DMV8;A0A0G2JIW1;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 36965720.0 5404720.0 13294900.0 18266100.0 False True 7402991.041066137 12707487.35764492 13952023.382138101 1.0 1.7165342072080718 1.884646800832655 22.81967685199355 -11.084944778688547 0.2717979919387063 3.8572969216891155e-14 1.9500236478305983 0.9992403948344708 0.010572143510861352 3.083841789083264 0.14327640164627503 1.975034207153391 0.06881197356338764 8.223472062013194e-12 11.084944778688547 1.9500236478305597 AFYPEEISSMVLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFYPEEISSMVLTK 14 0 P0DMV9;P0DMV8;A0A0G2JIW1;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 17405200.0 9970600.0 3523400.0 3911200.0 False True 8290995.672473252 3504418.7448598617 4729013.836654452 1.0 0.4226776714520312 0.5703794843790769 22.98311393588039 -10.342546352377836 8.747247964946132 1.000000893438664 0.4965285779157603 0.9393657523403982 0.060299012625879715 1.0505943841848047e-06 7.902053457329325e-08 0.05838437186849602 0.01946142264106525 4.54416034664127e-11 10.342546352377836 -0.5034723155229036 AFYPEEISSMVLTKMK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 AFYPEEISSMVLTKMK 16 1 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 98481400.0 7129400.0 37823000.0 53529000.0 True False 10815821.02895583 31073190.137552142 42948969.6874058 1.0 2.872938638163836 3.9709393833740365 23.36663984864637 -8.598021775062694 0.24189095399362137 9.2935315746515e-15 4.863090367748452 0.9993596346444156 0.031038573479138357 0.212355356809538 0.06811120776116977 0.6055595536923598 0.4479162827260699 2.523354251014611e-09 8.598021775062694 4.863090367748443 AFYPEEISSMVLTKMK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFYPEEISSMVLTKMK 16 1 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 5909080.0 748980.0 1355800.0 3804300.0 True False 1025898.1464234433 1295896.2729689572 2905802.6920178924 1.0 1.2631821955101488 2.832447550615333 19.968456073228197 -6.935968053183802 0.6960710369768213 0.9805704877157538 3.2097307988453045 0.9975865351931027 0.039741718963158826 0.08965526085724553 0.0633545849462144 0.03759197425928722 0.13763260702994515 1.1588625992571227e-07 6.935968053183802 2.229160311129551 up AFYPEEISSMVLTKMK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFYPEEISSMVLTKMK 16 1 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 13748200.0 4740500.0 4092000.0 4915700.0 True False 3941935.7897578324 4069955.583801596 5943550.142371212 1.0 1.0324763773109629 1.5077744690347548 21.910472845819115 -6.920726309372849 0.8193036141546757 0.9897856670961961 1.585720780861208 0.9943808825092668 0.017397752329280973 0.09774567552037003 0.10340688973796769 0.015048033070591776 0.04539507076002543 1.200255461000836e-07 6.920726309372849 0.5959351137650118 AFYPEEISSMVLTKMK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AFYPEEISSMVLTKMK 16 1 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 72388400.0 7129400.0 23060000.0 42199000.0 True False 9229148.84148407 21776690.728630867 34519214.99830464 1.0 2.3595556971350264 3.7402381943548617 23.137766170738818 -6.970933175894774 0.23483152103473276 0.4713456438562824 5.668129717770081 0.9999887739922424 0.003748255150879565 0.07600104662290082 0.007938550541155956 0.03424669154407247 0.1358751734688044 1.069219385416191e-07 6.970933175894774 5.196784073913799 AFYVNVLNEEQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AFYVNVLNEEQR 12 0 P04040 P04040 CAT Catalase 0 15227100.0 4174500.0 5500300.0 5552300.0 False True 5472809.925915509 4679676.680001479 4977801.257422397 1.0 0.8550775092410408 0.9095512770964166 22.383850321045724 -10.622768467330355 8.781439938472381 1.000057291118666 0.8823143935081276 0.8615563310791083 0.022238822602082518 2.4956159950443122e-05 1.072042522437781e-06 0.021543101105611702 0.007177549131427229 2.3835898788786474e-11 10.622768467330355 -0.11774289761053847 AFYVNVLNEEQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AFYVNVLNEEQR 12 0 P04040 P04040 CAT Catalase 0 16784700.0 5114500.0 3086000.0 8584200.0 False True 4952142.997035754 4318255.893277404 6335740.499520069 1.0 0.8719974152326011 1.2793936894214297 22.23962154343527 -6.822245660070089 1.3619956866935858 0.9311558839535988 1.2887320397914643 0.8894791268102562 0.05655040842670902 0.19059379102941065 0.6940794868395421 0.03262098823622493 0.07514989303496641 1.505755090039754e-07 6.822245660070089 0.3575761558378655 AFYVNVLNEEQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AFYVNVLNEEQR 12 0 P04040 P04040 CAT Catalase 0 12858900.0 4174500.0 0.0 8684400.0 False True 5717925.461620697 0.0 6633323.5808322625 1.0 0.0 1.1600926988915494 22.447060382568615 -10.679665898770093 4.539932302209818 1.0147538772542946 0.5800463494477782 0.1487372363759405 0.47360586110220526 0.07150526218081693 0.005045352096287063 0.46362449569946534 0.15285563439290495 2.0909040374782485e-11 10.679665898770093 -0.43470752780651634 AFYVNVLNEEQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AFYVNVLNEEQR 12 0 P04040 P04040 CAT Catalase 0 11199900.0 5114500.0 2133300.0 3952100.0 False True 4252933.360767093 2121807.489473104 4778465.8375542145 1.0 0.4989044759192742 1.1235694124989377 22.020026818869546 -6.693146682399831 1.8553506087691962 0.686770946032997 1.12148813857554 0.3851159557111212 0.2117954717906113 0.40995357213546346 2.738466179291196 0.09124181828982521 0.2366518228400898 2.0269979879441496e-07 6.693146682399831 0.43471719254254293 AGAGPLPSSESK(ub)YEIASVPVSLQTLKPVTDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGAGPLPSSESKYEIASVPVSLQTLKPVTDR 31 2 Q5T0D5;A0A0A0MRV3;Q9P2S5 Q5T0D5 WRAP73 WD repeat-containing protein WRAP73 1 11509500.0 2851900.0 4212700.0 4444900.0 True False 2761367.9955511335 5894853.078940286 3280647.345858296 1.0 2.1347582388285593 1.188051484316389 21.396951731780902 -10.277950589573612 4.471104869805727 0.9996128255353164 1.6614048615761026 0.3942303531441137 0.3864914141239367 273771455.6064485 716.1709869223572 1101856.5962980692 0.13230629112004513 5.272898486787352e-11 10.277950589573612 0.6617920360407862 AGAGPLPSSESK(ub)YEIASVPVSLQTLKPVTDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGAGPLPSSESKYEIASVPVSLQTLKPVTDR 31 2 Q5T0D5;A0A0A0MRV3;Q9P2S5 Q5T0D5 WRAP73 WD repeat-containing protein WRAP73 1 15260900.0 2851900.0 5857900.0 6551100.0 True False 2371481.2105917833 5826342.329997896 7920904.721135959 1.0 2.456836808984871 3.340066404810082 21.17735700721518 -8.58048124658534 0.2110390501995698 1.0714203577385364e-16 4.266193686007465 0.9996068239219816 0.019131642815272656 0.20027109044934716 0.057689220260329015 0.5365217333745067 0.41439931291547344 2.6273549767096384e-09 8.58048124658534 4.266193686007465 AGAGSATLSMAYAGAR ddPTM_RPMI8226_Bortezomib_1h_R1 2 AGAGSATLSMAYAGAR 16 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 245711000.0 78820000.0 89595000.0 77296000.0 False True 103333783.29396583 76227775.23857458 69298151.39558777 1.0 0.7376849352522051 0.6706243513648109 26.622736756018156 -13.999999999874738 0.1915134547394256 2.413596771167019 0.6232402162861029 0.9994886454532285 0.00321387983468654 12.375738244863225 0.13877994599032054 6.5317444766979875 0.04556938918094478 1.0000000002884254e-14 13.999999999874738 -1.7903565548809164 AGAGSATLSMAYAGAR ddPTM_RPMI8226_Bortezomib_2h_R1 2 AGAGSATLSMAYAGAR 16 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 211683400.0 77521800.0 51227600.0 82934000.0 False True 75060912.89228801 71683047.82840489 61211097.433330715 1.0 0.954998348225123 0.81548565124925 26.161558500628377 -6.950710297536449 0.5509941523698032 1.001918146707799 0.7620006072108596 0.9992558230217468 0.0021428741429758164 0.0832018466888143 0.03479214641395429 0.0023228649607387277 0.011575938616184361 1.1201848699383869e-07 6.950710297536449 -0.2399175394969395 AGAGSATLSMAYAGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGAGSATLSMAYAGAR 16 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 45780000.0 11391000.0 22491000.0 11898000.0 False True 17280979.793648265 18477305.32701492 9546355.084921338 1.0 1.0692278764081635 0.552419781685652 24.04268168167613 -6.873121646117337 1.117384555485097 1.0400032590040873 0.5202928327813475 0.9677038067968904 0.04116447023016627 0.13390029872948964 0.31055731083134636 0.028531934470488796 0.06794487107620334 1.339301495815323e-07 6.873121646117337 -0.5197104262227398 AGAGSATLSMAYAGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AGAGSATLSMAYAGAR 16 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 155018600.0 78820000.0 67002200.0 9196400.0 False True 107961884.03040922 64041821.25735403 7024399.725803272 1.0 0.5931891781299001 0.06506370085042917 26.685946817541048 -7.652701620751117 0.5479549892301374 1.009887577012342 4.299231899246361e-20 0.9940453344451771 0.029535910596506225 0.11724786916738038 0.10318700401301499 0.030999511583573152 0.07508681766454597 2.2248379263594982e-08 7.652701620751117 -1.009887577012342 down AGAGSATLSMAYAGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AGAGSATLSMAYAGAR 16 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 152139000.0 77521800.0 70125200.0 4492000.0 False True 64462811.49803794 69747421.62883754 5431256.431338662 1.0 1.0819792064291276 0.08425410411247691 25.941963776062654 -6.886976271357082 1.0401295812025768 1.0575595205967494 0.003364769261422843 0.9788902536468145 0.06570820509623694 0.12162984224279695 0.23646663287568914 0.04831623529530696 0.11921102304520426 1.2972501471886842e-07 6.886976271357082 -1.0541947513353265 down AGAGSATLSMAYAGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGAGSATLSMAYAGAR 16 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 44500000.0 11391000.0 17708000.0 15401000.0 False True 14745874.050178854 16722534.233416978 12598176.027604682 1.0 1.134048356612279 0.854352613126509 23.813808003768578 -6.776381330214549 1.5499703883437395 1.0762583490219917 0.8523832993955499 0.7543769585982472 0.056606881285536134 0.2562377129792609 1.2156243193416851 0.0287726673777936 0.06809963604289271 1.673472845831735e-07 6.776381330214549 -0.22387504962644178 AGAIAPCEVTVPAQNTGLGPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGAIAPCEVTVPAQNTGLGPEK 22 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5;F8VQY6;F8VRK7 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 25459100.0 11639000.0 3434100.0 10386000.0 False True 11269526.315866496 4805354.0385949155 7665595.026678712 1.0 0.42640248613017584 0.6802056104067331 23.425923541202398 -10.37456853885602 5.934420336287832 1.0000867838343699 0.5533040482684618 0.8050750155008125 0.10361469160029337 0.00011899380621360779 1.2540748596338295e-05 0.10034384305764106 0.03344149791586257 4.221156569583313e-11 10.37456853885602 -0.4467827355659081 AGAIAPCEVTVPAQNTGLGPEK(ub)TSFFQALGITTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTK 34 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 25295800.0 14686000.0 4256100.0 6353700.0 True False 14219800.968709989 5955582.925268285 4689475.363085744 1.0 0.4188232267366659 0.3297848804919785 23.761397936238865 -13.999999999999998 0.2641093861645798 5.34721580055077 0.2985004792109692 0.9995708278009543 0.0061566694004086975 14.60272052099991 0.16264452257962267 33.96439028440902 0.03810161690101969 1.0000000000000041e-14 13.999999999999998 -5.048715321339801 AGAIAPCEVTVPAQNTGLGPEK(ub)TSFFQALGITTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTK 34 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 131501000.0 28291000.0 44363000.0 58847000.0 True False 42919515.34914429 36446076.040298924 47215864.65644366 1.0 0.8491725906924895 1.1001024655648874 25.355130449361567 -6.743961332863751 1.6723313113741374 0.91067016410532 1.100375732454732 0.6224965942469085 0.06336873467983288 0.31071407781474586 1.7076913731272374 0.029959697557004044 0.07319723045516444 1.8031782785575373e-07 6.743961332863751 0.1897055683494121 AGAIAPCEVTVPAQNTGLGPEK(ub)TSFFQALGITTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTK 34 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 29160500.0 14686000.0 6944300.0 7530200.0 True False 12212059.700112553 6906889.677564366 9104730.00428905 1.0 0.5655794228962627 0.7455523660930953 23.54180321167314 -10.182755566421015 5.373214987493408 1.0000139918812094 0.6555658944946041 0.8300348978573454 0.0734736463901196 1.2315801541457844e-05 1.8730177489118495e-06 0.07114344094515122 0.023713517404467515 6.565146679078175e-11 10.182755566421015 -0.3444480973866053 AGAIAPCEVTVPAQNTGLGPEK(ub)TSFFQALGITTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGAIAPCEVTVPAQNTGLGPEKTSFFQALGITTK 34 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 107270000.0 28291000.0 27210000.0 51769000.0 True False 36623257.198982485 25695739.580487657 42347573.194796875 1.0 0.701623545958156 1.1563027549601304 25.126256771454017 -6.729682517791988 1.7245572217643872 0.8203761636038142 1.1560091354229804 0.5577630730136249 0.12543295387476017 0.3368111279759807 1.962330098852498 0.057644127473779054 0.14308217481444874 1.8634488755241565e-07 6.729682517791988 0.3356329718191663 AGAIFVPIHLVK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGAIFVPIHLVKER 14 1 H3BMJ2;Q6ZRI6-2;Q6ZRI6 H3BMJ2 C15orf39 Uncharacterized protein C15orf39 1 6668700.0 1088900.0 1894900.0 3684900.0 True False 1427558.4449226016 1612188.3062623488 3303621.8960567336 1.0 1.1293326112121156 2.314176283154451 20.44511838074344 -6.927665001356362 0.765711381897179 0.9803366046870752 2.543563942979855 0.9960592682608742 0.03712442670816541 0.09386808985405651 0.08375206029842745 0.03336398369720676 0.10861650978885795 1.1812314424162311e-07 6.927665001356362 1.5632273382927797 up AGAIFVPIHLVK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGAIFVPIHLVKER 14 1 H3BMJ2;Q6ZRI6-2;Q6ZRI6 H3BMJ2 C15orf39 Uncharacterized protein C15orf39 1 27350200.0 2858400.0 4429800.0 20062000.0 True False 2767661.656609058 6198642.241101829 14807160.352900852 1.0 2.239667636504533 5.350061600753107 21.4002361553019 -6.955384067763129 0.4962294528663996 0.9356201652429781 6.787405957367454 0.9995588636895714 0.03843227975274299 0.08139311416455543 0.02755224307818513 0.045397289780347634 0.2565528211945168 1.1081943515495144e-07 6.955384067763129 5.851785792124476 AGAIFVPIHLVK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGAIFVPIHLVKER 14 1 H3BMJ2;Q6ZRI6-2;Q6ZRI6 H3BMJ2 C15orf39 Uncharacterized protein C15orf39 1 63182400.0 4600400.0 7187000.0 51395000.0 True False 6979143.134290182 5904423.697712707 41236755.72277126 1.0 0.846009830161367 5.908569996245716 22.7346184894562 -6.899886371723665 0.9620082548705859 0.788860544966754 6.438704544385085 0.9865090533461767 0.2730767099792268 0.11148821319402825 0.17790163804134113 0.21294777789197655 0.5537250397818957 1.2592548385905503e-07 6.899886371723665 5.649843999418331 up AGAIFVPIHLVK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGAIFVPIHLVKER 14 1 H3BMJ2;Q6ZRI6-2;Q6ZRI6 H3BMJ2 C15orf39 Uncharacterized protein C15orf39 1 15627200.0 1088900.0 2220300.0 12318000.0 True False 1491495.7564160447 2122199.804449756 9408742.097173307 1.0 1.4228668069088224 6.308259381026887 20.508328442266333 -6.923947934566265 0.7948896964946306 0.9067601140806341 7.172371520090399 0.9952093463625528 0.16672821331851542 0.09590410073100716 0.09398010356951231 0.1467437252390686 0.4576304563259705 1.1913848287454648e-07 6.923947934566265 6.265611406009765 up AGAIFVPIHLVK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGAIFVPIHLVKER 14 1 H3BMJ2;Q6ZRI6-2;Q6ZRI6 H3BMJ2 C15orf39 Uncharacterized protein C15orf39 1 28347300.0 2858400.0 4795900.0 20693000.0 True False 2376886.2485906114 4770063.534788387 25019810.626378193 1.0 2.0068539407877948 10.526297016196647 21.180641430736177 -6.929067912935871 0.7544071104327615 0.8658659265581433 12.234473485870923 0.996351818223395 0.25810429283707537 0.09312467529195069 0.08007329936199331 0.23385482298889756 0.7748511578653796 1.177421839414605e-07 6.929067912935871 11.36860755931278 AGAIFVPIHLVK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGAIFVPIHLVKER 14 1 H3BMJ2;Q6ZRI6-2;Q6ZRI6 H3BMJ2 C15orf39 Uncharacterized protein C15orf39 1 78440900.0 4600400.0 4913500.0 68927000.0 True False 5955308.487441206 4640059.405686371 56382993.25074394 1.0 0.7791467755988652 9.467686412827591 22.50574481154865 -6.901066577629947 0.954482087640283 0.649258937366697 10.39977028719318 0.9870900619066669 0.4595740673280675 0.11062498365913945 0.17301715034436355 0.36037701045325693 0.9427771613829052 1.2558374282329523e-07 6.901066577629947 9.750511349826482 up AGAISASGPELQGAGHSK(ub)LQVTMPGIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGAISASGPELQGAGHSKLQVTMPGIK 27 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 16349700.0 5826600.0 6882700.0 3640400.0 True False 4845076.0621459745 6845621.528991018 4401590.808692182 1.0 1.4129027988796867 0.9084668129529087 22.208087883802392 -6.689088918069051 1.8692269395394663 1.2590736333510668 0.9102066431871627 0.3663994329942234 0.17465951459862694 0.4186049237692628 2.834919354601828 0.07476305698961597 0.19494270079063866 2.0460256876327766e-07 6.689088918069051 -0.3488669901639041 AGAK(ub)LDIQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGAKLDIQDK 10 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 18100800.0 4245600.0 4134400.0 9720800.0 True False 5566022.714448884 3517563.6357649807 8714984.8644979 1.0 0.6319707655223376 1.5657472690283134 22.40821536551721 -6.799786427130703 1.4568125133135876 0.7968875769812102 1.5785656725797326 0.8315328841451253 0.157632608973021 0.22106117947260276 0.9262619295993756 0.08512497576712968 0.19799264560571556 1.5856727865936787e-07 6.799786427130703 0.7816780955985224 AGAK(ub)LDIQDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGAKLDIQDK 10 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 43001000.0 4720700.0 11200300.0 27080000.0 True False 4570843.962480539 15672638.198792892 19986935.617413778 1.0 3.4288280955203616 4.372701361384282 22.12402913899946 -9.239788134898587 0.3187998279494562 7.690099631558486e-19 4.709788783998914 0.9984925355615863 0.0551597866243943 0.6453714927690198 0.1201914360110198 1.055988760751571 0.3046442278991806 5.757207269582656e-10 9.239788134898587 4.709788783998914 AGAK(ub)LDIQDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGAKLDIQDK 10 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 15783100.0 2196900.0 9533200.0 4053000.0 True False 3332857.914903509 7831925.976768437 3251922.7735069953 1.0 2.3499129506080916 0.975715994061854 21.668328383671987 -6.650270886526835 2.007910378373254 1.8757763404883827 0.981521256594749 0.19509352544087077 0.576119859389186 0.5078071621241216 3.9247055061220077 0.23269365461185657 0.6380024280962014 2.2373251956578898e-07 6.650270886526835 -0.8942550838936337 AGAK(ub)LDIQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGAKLDIQDK 10 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 19080600.0 4245600.0 3527900.0 11307100.0 True False 5815313.053025945 3372025.712794799 8636595.857034275 1.0 0.5798528268465609 1.485147192985647 22.471425427040103 -6.780497681383505 1.5338300978578305 0.7622570903579317 1.492443780407934 0.7691820286378537 0.1777140765969213 0.24980111784521436 1.1608187073286638 0.09125127283668763 0.21523441823582967 1.6576861868997956e-07 6.780497681383505 0.7301866900500024 AGAK(ub)LDIQDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGAKLDIQDK 10 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 27303900.0 4720700.0 10826700.0 11756500.0 True False 3925471.212469106 10768374.418168318 14214729.794085689 1.0 2.7432055504478026 3.6211524743661743 21.904434414433737 -8.996570177463903 0.25094380629703517 1.3249390210343528e-19 4.220905732174754 0.9991500867706884 0.03175788646211454 0.4662732679493284 0.08496030538523255 0.7769540493281147 0.36617768766176817 1.0079287254227994e-09 8.996570177463903 4.220905732174754 AGAK(ub)LDIQDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGAKLDIQDK 10 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 19891800.0 2196900.0 16039800.0 1655100.0 True False 2843930.357373182 15147171.029882632 1353888.7827601116 1.0 5.326139928360774 0.47606256575517597 21.439454705764437 -6.671470328470792 1.9321292710217246 3.7578593491902765 0.4955247256839776 0.28558510603990894 1.8370295234937106 0.4577532873174975 3.2958854230293184 0.7650432511730381 2.0401164034307455 2.1307361370640977e-07 6.671470328470792 -3.262334623506299 AGAK(ub)LDIQDKDGDTPLHEALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGAKLDIQDKDGDTPLHEALR 21 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 40567400.0 6979300.0 11422100.0 22166000.0 True False 6757745.94177567 15983004.095464606 16360059.634253826 1.0 2.3651383513338917 2.4209344025672332 22.68811068256189 -10.742791421806814 0.5855304303226503 1.6113304690778792e-15 2.4148113011470054 0.9998618927127452 0.007721923492850004 2.3213986666834026 0.2864456441197155 3.3055863585690064 0.009885038742374602 1.8080422642438345e-11 10.742791421806814 2.4148113011470036 AGAK(ub)LDIQDKDGDTPLHEALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGAKLDIQDKDGDTPLHEALR 21 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 104305200.0 7828200.0 77661000.0 18816000.0 True False 11875951.71807895 63801787.78183742 15097009.35265422 1.0 5.372351563598136 1.2712252214424047 23.5015397973549 -6.63107022914679 2.0765540241329807 3.8783398853609197 1.2877934411548824 0.12134126775887322 1.8750030566198495 0.5562418967740381 4.572271409196681 0.7381473040490536 2.0769817633900636 2.3384590591737158e-07 6.63107022914679 -2.590546444206037 AGAK(ub)LDIQDKDGDTPLHEALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGAKLDIQDKDGDTPLHEALR 21 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 19975100.0 6979300.0 8234300.0 4761500.0 True False 5803597.185414369 8189940.191519422 5757107.635311452 1.0 1.4111834315624838 0.9919895284566346 22.468515957996168 -6.650630589962791 2.006608704271228 1.2666940224030787 0.9937646937462618 0.1964387194155719 0.17547261571017886 0.5070202300714683 3.913948065967626 0.07090830565413292 0.19432533200306798 2.2354729032392907e-07 6.650630589962791 -0.27292932865681696 AGAK(ub)LDIQDKDGDTPLHEALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGAKLDIQDKDGDTPLHEALR 21 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 107555100.0 7828200.0 79331000.0 20395900.0 True False 10133759.216891412 74916160.11244634 16684055.479606656 1.0 7.392731414771792 1.6463836491987014 23.27266611944735 -6.620581032369223 2.1140708390654175 5.239889352191888 1.6681318221426498 0.08491194327203977 2.748654795062249 0.5838514167079205 4.959015048671533 1.0678815905486443 3.04851167191394 2.395625722791636e-07 6.620581032369223 -3.571757530049238 AGATVYITGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGATVYITGR 10 0 Q96LJ7;H0YNC2 Q96LJ7 DHRS1 Dehydrogenase/reductase SDR family member 1 0 6689000.0 2016800.0 2433700.0 2238500.0 False True 2644044.330718983 2070601.446488298 2006881.493208226 1.0 0.7831190356499238 0.7590196086699136 21.334314934964137 -13.999999999999693 0.31021072025450386 3.0990283943509738 0.7536946377656448 0.999672456907626 0.001961224845603039 17.28458918987201 0.17722139688794025 23.42113978896258 0.008343984378950368 1.0000000000007076e-14 13.999999999999693 -2.3453337565853287 AGAVEK(ub)GVPLYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGAVEKGVPLYR 12 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 1 4946300.0 1748900.0 1339400.0 1858000.0 True False 2292824.836371691 1139566.7409403082 1665751.983194497 1.0 0.4970143043040434 0.7265064285636782 21.12869471170444 -10.351168389116777 5.875368502030521 1.000059837722959 0.6117603664338609 0.7923567331970653 0.09368976740391877 7.344638325111102e-05 8.110903679509436e-06 0.09072864832066548 0.030238242405451622 4.454834874744181e-11 10.351168389116777 -0.38829947128909814 AGAVEK(ub)GVPLYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGAVEKGVPLYR 12 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 1 16426300.0 2923500.0 2151800.0 11351000.0 True False 2830695.092742995 3011024.961488757 8377832.577299262 1.0 1.0637051546837633 2.9596379344343267 21.43272492758304 -6.914039728786298 0.8677619561266229 0.9485291757788477 3.227077625891466 0.9923590620102162 0.07947005823794026 0.1018071195472175 0.12472174080730117 0.06639176497235859 0.18883336450798902 1.2188780921840597e-07 6.914039728786298 2.2785484501126185 up AGAVEK(ub)GVPLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGAVEKGVPLYR 12 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 1 5554000.0 1748900.0 1298700.0 2506400.0 True False 2395515.592245401 1241319.1397734052 1914439.9409283288 1.0 0.5181845377219495 0.799176572728486 21.191904773227332 -10.236671480718233 5.702364592022407 1.00001514898411 0.6586805552252119 0.6629944178888305 0.11471451792540499 2.2094214842681466e-05 2.95759869129919e-06 0.1110767789426371 0.03702395145777189 5.7986716737486836e-11 10.236671480718233 -0.3413345937588982 AGAVEK(ub)GVPLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGAVEKGVPLYR 12 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 1 11142500.0 2923500.0 4056400.0 4162600.0 True False 2431019.7830096027 4034547.3680676403 5032980.414312183 1.0 1.659611080199796 2.0703165188073265 21.213130203017315 -8.83574313624108 0.13231631818543568 1.2940232929251845e-15 2.936418016861079 0.9999108617587147 0.0041624388541291685 0.35372328713108225 0.03986803060554552 0.47854930879198065 0.34372792119863255 1.459677332142699e-09 8.83574313624108 2.9364180168610776 AGAVGAHLPASGLDIFGDLK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGAVGAHLPASGLDIFGDLKK 21 1 B4DI03;K7EJQ7;Q9BY50;A0A0A0MR04 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 209326100.0 3077100.0 74761000.0 131488000.0 True False 4668185.666143017 61419315.43964087 105499339.1667624 1.0 13.156999278134366 22.599645068086772 22.15443051132423 -7.945272558815506 0.39371829189169905 1.0557585052686347e-12 25.93766320928544 0.9967974668038548 0.5003315401988621 0.11786192406369637 0.09341691257798378 1.2224473340772888 2.3076462405405356 1.1342987178631685e-08 7.945272558815506 25.937663209284384 AGAVGAHLPASGLDIFGDLK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGAVGAHLPASGLDIFGDLKK 21 1 B4DI03;K7EJQ7;Q9BY50;A0A0A0MR04 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 170599100.0 3077100.0 60923000.0 106599000.0 True False 3983366.608709101 57532581.49437892 87199075.798106 1.0 14.443205244677099 21.890798503822577 21.925556833416678 -8.37449147496003 0.43924753682291606 4.34843758788136e-17 23.23144369354727 0.995317866665319 0.5915383409837298 0.15842875434787232 0.13840934205105862 1.7155419046108085 1.7409433759230553 4.221905664143826e-09 8.37449147496003 23.23144369354727 AGDEFVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGDEFVEK 8 0 A0A0D9SFP2;E9PF18;Q16836;Q16836-3;Q16836-2;A0A1W2PQV5;A0A0A0MSE2;A0A1W2PQC2;A0A1W2PRT2;A0A1W2PQ55;A0A1W2PP40 A0A0D9SFP2 HADH Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 0 3517780.0 995880.0 367200.0 2154700.0 False True 964266.3345171504 513824.8749227031 1590319.430385578 1.0 0.5328661351430435 1.649253295959896 19.8790721545206 -6.793043738376421 1.484080388255163 0.7399424343097849 1.66215333651171 0.8110408938916331 0.198994416954233 0.23085199536500928 1.0043517459699352 0.10552165692569938 0.2465231138166742 1.6104834330764242e-07 6.793043738376421 0.9222109022019251 AGDTLSGTCLLIANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGDTLSGTCLLIANK 15 0 Q86X55-1;Q86X55 Q86X55-1 CARM1 Histone-arginine methyltransferase CARM1 0 4090300.0 1369000.0 1233200.0 1488100.0 False True 1875156.2958339278 1178713.1463529414 1136641.428381523 1.0 0.6285946131379618 0.6061582337999354 20.83857941977375 -13.999999999999998 0.39932850173411333 7.233741668397849 0.6048203388915839 0.9998368164006927 0.0023070745595896386 26.669792020742612 0.20817614849524765 144.01498140855045 0.005751284036214068 1.0000000000000041e-14 13.999999999999998 -6.628921329506265 AGDWQCPNPGCGNQNFAWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGDWQCPNPGCGNQNFAWR 19 0 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2 B0QYK0 EWSR1 RNA-binding protein EWS 0 4646000.0 0.0 4646000.0 0.0 False True 0.0 3952834.9099661526 0.0 0.0 AGDWQCPNPGCGNQNFAWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGDWQCPNPGCGNQNFAWR 19 0 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2 B0QYK0 EWSR1 RNA-binding protein EWS 0 8609200.0 0.0 5190100.0 3419100.0 False True 0.0 4960784.2206344465 2611578.9985748683 0.0 AGEEHYNCISALHK(ub)SMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGEEHYNCISALHKSMR 17 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 12448400.0 3382100.0 5208500.0 3857800.0 True False 4433965.852302989 4431412.102573981 3458631.8626306453 1.0 0.9994240483995424 0.7800312356565042 22.08016622881608 -6.9074744803937005 0.9127646568909296 1.0073472258589729 0.7531585260989976 0.9899330228786192 0.010390499260640982 0.10611174519343845 0.1480028336050894 0.00840201260768189 0.022806815251979203 1.2374439013206065e-07 6.9074744803937005 -0.25418869975997527 AGEEHYNCISALHK(ub)SMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGEEHYNCISALHKSMR 17 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 7198000.0 2648400.0 2261500.0 2288100.0 True False 2564327.991660864 3164528.7435667044 1688777.9684713634 1.0 1.2340577156501351 0.6585655087661293 21.290149371717398 -6.79629929791534 1.471100826503173 1.1297510541553721 0.6513392716315854 0.8210909139185362 0.09995059008070196 0.2260804167522349 0.9662958083208651 0.05346190144890463 0.1246164807300591 1.598456058693843e-07 6.79629929791534 -0.4784117825237867 AGEEHYNCISALHK(ub)SMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGEEHYNCISALHKSMR 17 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 11482400.0 3382100.0 2645400.0 5454900.0 True False 4632553.767815868 2528517.4808320384 4166564.9671919732 1.0 0.545815031527237 0.8994099531318345 22.14337629033897 -9.828160830367219 6.302144464921804 1.0000000114284455 0.7226124923294408 0.4507128465628002 0.1443545222621215 2.3098853499926644e-08 4.296266185386025e-09 0.13977067141581256 0.04659022172252689 1.485385464148526e-10 9.828160830367219 -0.2773875190990047 AGEEHYNCISALHK(ub)SMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGEEHYNCISALHKSMR 17 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 8568700.0 2648400.0 1575200.0 4345100.0 True False 2202261.944013211 1566714.0849472801 5253640.320527515 1.0 0.7114113238011263 2.3855655930528123 21.070554647151674 -6.862475945376127 1.1732439080913748 0.8422873950484051 2.4705230734705625 0.956574907973827 0.15227725367394784 0.1442682564393019 0.37596605356477575 0.10112907376479886 0.23674957475273298 1.3725369807312246e-07 6.862475945376127 1.6282356784221574 up AGEEHYNCISALHK(ub)SMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGEEHYNCISALHKSMR 17 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 28992900.0 6036800.0 6881100.0 16075000.0 True False 7814756.6031182185 6498160.736026964 13149514.943428673 1.0 0.8315243923827506 1.6826518868395461 22.89776950935108 -6.855278185189385 1.2093176897828295 0.9095080076637138 1.720310517693779 0.9476445099622822 0.08420325267852516 0.15174437032036023 0.42439860349091446 0.05440078417583564 0.126390307128078 1.395474210588532e-07 6.855278185189385 0.8108025100300652 AGEGLWVILHLYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGEGLWVILHLYK 13 0 Q9H2J4;H7BZP2;C9JST4 Q9H2J4 PDCL3 Phosducin-like protein 3 0 57498400.0 12668500.0 25475900.0 19354000.0 False True 19219040.691408418 20929526.600884806 15528673.416840438 1.0 1.0889995466964715 0.8079837941017679 24.196032990734867 -6.821534449854076 1.365156562015078 1.0478978027851429 0.8016414343444177 0.8878875173148968 0.0392642787014701 0.19149661830759232 0.7008238142527144 0.02259888697423505 0.052068379481287286 1.5082229679382063e-07 6.821534449854076 -0.24625636844072518 AGEGLWVILHLYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGEGLWVILHLYK 13 0 Q9H2J4;H7BZP2;C9JST4 Q9H2J4 PDCL3 Phosducin-like protein 3 0 37083100.0 12668500.0 14757100.0 9657500.0 False True 16399622.983468616 13935854.412466552 7899934.094318037 1.0 0.8497667554012902 0.48171437247560156 23.967159312827317 -6.955894182310552 0.48988220564119106 1.0080631494987755 0.30781398706369795 0.9995863206709084 0.004428406429494786 0.081201731373602 0.026808757645115068 0.00529783600758448 0.030355870486226226 1.1068934503997555e-07 6.955894182310552 -0.7002491624350775 down AGEIK(ub)GFTGIDSEYEKPEAPELVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGEIKGFTGIDSEYEKPEAPELVLK 25 2 O43252 O43252 PAPSS1 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 1 124420500.0 56735800.0 47954700.0 19730000.0 True False 54934753.08460674 67103261.79045688 14562121.112687385 1.0 1.221508389909554 0.2650803051805804 25.711215786851298 -6.845729198628546 1.2554106222779808 1.1179128316233273 0.22986130362754525 0.9338655679605791 0.10512500377271602 0.1622253949278197 0.494144236725404 0.06558744614177306 0.1514260234069156 1.4264967987246694e-07 6.845729198628546 -0.8880515279957821 down AGEIK(ub)GFTGIDSEYEKPEAPELVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGEIKGFTGIDSEYEKPEAPELVLK 25 2 O43252 O43252 PAPSS1 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 1 146177000.0 101317000.0 10627000.0 34233000.0 True False 153705296.26486367 8730528.820870021 27466832.5451431 1.0 0.05680044235968062 0.17869802285675626 27.19559163631633 -10.145837376763325 5.201217179276518 1.0000315667391078 0.11774923260751824 0.9858845921831862 0.04976447885233987 556761413.4903938 7.085018552825796 212273.90309723603 0.01703570476827771 7.147639220669127e-11 10.145837376763325 -0.8822823341315895 AGEIK(ub)GFTGIDSEYEKPEAPELVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGEIKGFTGIDSEYEKPEAPELVLK 25 2 O43252 O43252 PAPSS1 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 1 54239700.0 12823000.0 26973700.0 14443000.0 True False 17564009.628545247 25781912.743902348 11031860.862922072 1.0 1.4678830909999765 0.6280946717879814 24.066118894670584 -6.75548826600249 1.629404335638802 1.2732908146497188 0.6256870211741876 0.6723030750903605 0.19668617204363428 0.29056265870536385 1.519298895200565 0.09529059180016097 0.23003454195468925 1.755948336697087e-07 6.75548826600249 -0.6476037934755312 AGEIK(ub)GFTGIDSEYEKPEAPELVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGEIKGFTGIDSEYEKPEAPELVLK 25 2 O43252 O43252 PAPSS1 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 1 120225500.0 56735800.0 47947700.0 15542000.0 True False 47178331.52210571 47689396.22322669 18791760.34191126 1.0 1.0108326149872748 0.39831337259365057 25.491621062285574 -6.902877821086164 0.9429240474816702 1.0234947088389292 0.33013232509357243 0.9879436774204026 0.0314278985700154 0.10931697928006578 0.1657257630663392 0.024856748039152776 0.06565651414867767 1.2506108117526635e-07 6.902877821086164 -0.6933623837453569 down AGEIK(ub)GFTGIDSEYEKPEAPELVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGEIKGFTGIDSEYEKPEAPELVLK 25 2 O43252 O43252 PAPSS1 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 1 212781400.0 101317000.0 68295000.0 43169400.0 True False 131156853.75664748 64494323.21387013 35313012.15544947 1.0 0.49173429650527384 0.2692425987967837 26.96671795840878 -11.153003864353426 0.1567804435650492 2.056079699089493 1.1918598507014335e-16 0.9996076229481423 0.0060582318562052385 3.4779594908422005 0.09281016145195725 1.4962319251270615 0.19481528076857962 7.030660639723405e-12 11.153003864353426 -2.056079699089493 AGEIVVFK(ub)VEGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGEIVVFKVEGR 12 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 141599000.0 10646000.0 100900000.0 30053000.0 True False 13781456.864033362 95284826.30177158 24583662.369820345 1.0 6.913987921730139 1.7838217404996142 23.71622507035382 -6.611651361853265 2.147148516789359 4.9466116538770235 1.8021682781729698 0.05572339665192272 2.548605230485349 0.6080582747559361 5.314364059743968 0.9792592273765838 2.8294687225474187 2.44539285052471e-07 6.611651361853265 -3.1444433757040535 AGEK(ub)HCFTSNEAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGEKHCFTSNEAAR 14 1 Q9BV44;H7C3J3;H7C0R6 Q9BV44 THUMPD3 THUMP domain-containing protein 3 1 8960040.0 914920.0 955120.0 7090000.0 True False 1388000.529611506 784671.3736133781 5688658.392342612 1.0 0.5653249814198583 4.0984554911768205 20.404576687721434 -6.876102797673576 1.101260915180989 0.7422525027429299 4.330902370905735 0.9704055498599157 0.2706245532028063 0.13114029395834953 0.29359955792075837 0.18991102822878508 0.45505216637648727 1.3301395361652489e-07 6.876102797673576 3.588649868162805 up AGEK(ub)HCFTSNEAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGEKHCFTSNEAAR 14 1 Q9BV44;H7C3J3;H7C0R6 Q9BV44 THUMPD3 THUMP domain-containing protein 3 1 3161960.0 766430.0 1411900.0 983630.0 True False 1049799.8829919633 1349517.5894710666 751316.8524957435 1.0 1.285499847480358 0.7156762585593612 20.001682911186375 -6.7704865449036475 1.5725364245308127 1.1636578129146689 0.7124098476669045 0.732396187989895 0.1203403455849967 0.26566617791865454 1.296588398598224 0.06031639153699359 0.14351725405523255 1.6963421566777685e-07 6.7704865449036475 -0.45124796524776434 AGEK(ub)HCFTSNEAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGEKHCFTSNEAAR 14 1 Q9BV44;H7C3J3;H7C0R6 Q9BV44 THUMPD3 THUMP domain-containing protein 3 1 5010020.0 914920.0 1023100.0 3072000.0 True False 1184381.9757694346 966163.5856228211 2512927.52138183 1.0 0.8157533679074711 2.121720503006899 20.175703009813883 -6.871165380437701 1.1278621441084484 0.89501626277766 2.1999343956075204 0.96583503937384 0.10667611547631987 0.13574496922146456 0.322014245114401 0.07334813681907824 0.17402143777046597 1.3453479445969934e-07 6.871165380437701 1.3049181328298602 up AGELTEDEVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGELTEDEVER 11 0 P62269 P62269 RPS18 40S ribosomal protein S18 0 21302200.0 6098200.0 1476000.0 13728000.0 False True 5904615.978985908 2065374.497238316 10132224.968827797 1.0 0.34978980929307363 1.7159837328774024 22.49341180282833 -6.777290756416559 1.5465203417004243 0.6305435808884389 1.7258851202402536 0.7576737277699092 0.27466585826404993 0.25479618572288837 1.2035026280760548 0.13991435148484233 0.33088176845087724 1.6699722079552318e-07 6.777290756416559 1.0953415393518147 AGETPYNIDCSHQK(ub)SILTQIFGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGETPYNIDCSHQKSILTQIFGAR 24 1 H0Y8E4;E9PH70;A0A1W2PPB7;Q9ULH0-3;Q9ULH0-2;Q9ULH0-4;Q9ULH0 H0Y8E4 KIDINS220 Kinase D-interacting substrate of 220 kDa 1 5574700.0 1296100.0 2125900.0 2152700.0 True False 1699199.6514502533 1808724.0066932957 1929959.2541565103 1.0 1.0644564369758223 1.135804878790615 20.696423944644884 -6.96981598895378 0.2625464846459283 0.980581493790049 1.2218036834354173 0.9999809001227372 0.00024233612561343557 0.07636242893414039 0.009243688414676755 0.0014652751763392286 0.006706452866312458 1.071973405331865e-07 6.96981598895378 0.24122218964536835 AGEVFIHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGEVFIHK 8 0 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 19134900.0 1424100.0 9299500.0 8411300.0 False True 1867008.891004017 7912050.849167082 7540979.3628869215 1.0 4.2378217304108485 4.039069872255202 20.832297367256185 -10.103049782807958 4.3538652100950515 0.9996109778178187 4.138445801592198 0.997001182216985 0.08114010721639787 2641960.5375056686 1532681.0408705773 9104.453804040144 0.02777641665641763 7.88769696435178e-11 10.103049782807958 3.138834823774379 AGEVFIHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGEVFIHK 8 0 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 21308100.0 4791500.0 2473600.0 14043000.0 False True 4639396.455234492 3461321.3796535935 10364717.019030344 1.0 0.7460714799978536 2.2340658141720446 22.145505704919493 -6.862960428245461 1.1707816230678763 0.861005389995403 2.3102712315409932 0.9571329425208356 0.13456109796838067 0.1437778305197771 0.372837906966762 0.08953258281913042 0.20972879740006065 1.371006682944975e-07 6.862960428245461 1.4492658415455901 up AGEVFIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGEVFIHK 8 0 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 17587400.0 1424100.0 8193400.0 7969900.0 False True 1950628.2548554384 7831388.496049454 6087573.765242853 1.0 4.014803167418408 3.1208272258385823 20.895507428779077 -9.89525828349951 8.848545528430058 1.0000000214527764 3.5678151747820386 0.9166705218052992 0.3649641498657867 3.1928613443752232e-09 0.0 0.35337501333253746 0.11779167286607845 1.2727459287698658e-10 9.89525828349951 2.567815153329262 AGEVFIHK(ub)DK(ub)GFGFIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGEVFIHKDKGFGFIR 16 2 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 2 9335400.0 1966400.0 3453600.0 3915400.0 True False 1903977.7083529392 4832640.490286074 2889839.2805177947 1.0 2.538181234520131 1.51779050134872 20.86058515708929 -10.526751750406504 5.326393366000719 0.9969005773188794 2.02798586793443 0.5750568867239428 0.41657277242241103 0.015356148286214535 0.0013643861668889727 0.403972819641395 0.13444828417295207 2.9733651686141786e-11 10.526751750406504 1.0310852906155503 AGEVFIHK(ub)DK(ub)GFGFIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGEVFIHKDKGFGFIR 16 2 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 2 8789500.0 2947600.0 3456600.0 2385300.0 True False 4037407.375894875 3303875.9825523626 1821941.2667955428 1.0 0.8183162299345808 0.45126515537504236 21.94499773194933 -6.959847030397465 0.4375838337290828 1.0134597474070677 0.24186809454854002 0.9997644846243109 0.0035026974325345966 0.07975579991173244 0.02133351736369016 0.0048252268621509645 0.030426771016604546 1.0968644717771696e-07 6.959847030397465 -0.7715916528585276 down AGEVFIHK(ub)DK(ub)GFGFIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGEVFIHKDKGFGFIR 16 2 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 2 7857700.0 1966400.0 4495400.0 1395900.0 True False 1635148.7262904316 4471182.387932966 1687776.2360876324 1.0 2.7344193931988574 1.0321851516935672 20.640990432523566 -6.6418239508108226 2.0377134208780787 2.1326422948416335 1.0392752288182083 0.16164952725723725 0.7417703113486599 0.5288239037898151 4.1988580845229295 0.29619802645762544 0.8214747439580555 2.2812666376317373e-07 6.6418239508108226 -1.0933670660234251 AGEVFIHKDK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGEVFIHKDK 10 1 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 103454800.0 21367000.0 22075000.0 60012800.0 True False 32415301.136939943 18135543.777237773 48151243.77545534 1.0 0.5594747894095855 1.4854479855682408 24.95017163977555 -6.777310275995554 1.5461199058004278 0.7496968282179715 1.4922055387742916 0.7578517821292503 0.18609457918410444 0.25476644439073 1.2026888489571121 0.09481428911507458 0.22425161995989246 1.6698971519200894e-07 6.777310275995554 0.7425087105563202 AGEVFIHKDK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGEVFIHKDK 10 1 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 100867000.0 21367000.0 19004000.0 60496000.0 True False 27660002.706537783 17946410.694141388 49486348.7413786 1.0 0.6488217258886794 1.7890941395201632 24.721297961868 -6.824033387752478 1.354508296271207 0.8114543776891515 1.8161707039292077 0.8933721443383998 0.15570046812619973 0.1882942394896827 0.6777114355162754 0.09030775351285716 0.20793685735691728 1.4995695469515585e-07 6.824033387752478 1.004716326240056 AGFAGDDAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGFAGDDAPR 10 0 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38;P0CG39 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 228492300.0 4846300.0 128680000.0 94966000.0 False True 6353546.231635957 109481445.59071152 85139829.29819626 1.0 17.23154937404484 13.400363544104382 22.599130626208222 -9.792482721769344 6.025085000416963 0.9999992406780313 15.31595645910064 0.9490241779343207 1.564075065615226 1.596535249090131e-05 3.1761142992487815e-06 1.514409350652476 0.5048030567652617 1.612565181316375e-10 9.792482721769344 14.315957218422609 AGFAGDDAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGFAGDDAPR 10 0 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38;P0CG39 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 334575000.0 75636000.0 28329000.0 230610000.0 False True 73234976.58105329 39640917.43378338 170206322.84829387 1.0 0.5412839504346744 2.324112477320409 26.12602949971935 -6.838425480971919 1.2896962316739455 0.7559038029394951 2.380943872426132 0.9217131286821679 0.2114932474690446 0.1706445277978878 0.5520351011075815 0.12862023269848838 0.2962015008927195 1.450689671573601e-07 6.838425480971919 1.625040069486637 up AGFAGDDAPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGFAGDDAPR 10 0 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38;P0CG39 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 1388422600.0 5718800.0 1379800000.0 2903800.0 False True 8675837.700282302 1133563909.5733953 2329862.657219249 1.0 130.65757437307875 0.2685461321093452 23.048571633954005 -9.796730362209235 11.161714762325678 1.0028705933153752 65.46306025181487 0.2457927968107383 53.23109790042053 0.0 0.0 51.540790437147 17.180262968502813 1.5968702787268862e-10 9.796730362209235 64.46018965849949 AGFAGDDAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGFAGDDAPR 10 0 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38;P0CG39 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 264166300.0 4846300.0 138960000.0 120360000.0 False True 6638108.076333058 132820287.72073044 91933446.89201 1.0 20.008756439847147 13.84934469804456 22.662340687731113 -10.265944743504253 6.686159922449963 0.9998041518287692 16.929050568945346 0.8991674956809894 2.514569313854025 0.00737939698285281 0.0008101163601506819 2.434728528409797 0.8115737562867265 5.420698550707043e-11 10.265944743504253 15.929246417116577 AGFAGDDAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGFAGDDAPR 10 0 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38;P0CG39 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 79265800.0 75636000.0 2094100.0 1535700.0 False True 62894685.24293292 2082818.6676536947 1856807.7697254645 1.0 0.033115972511965595 0.02952249085202477 25.906434775153627 AGFAGDDAPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGFAGDDAPR 10 0 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38;P0CG39 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 20711400.0 5718800.0 8013000.0 6979600.0 False True 7403099.334401091 7567069.506006892 5709384.416743697 1.0 1.0221488547160047 0.7712154273296111 22.819697956046454 -6.885380967433979 1.049286578883704 1.0150133078394177 0.7514865648282265 0.9777747158222476 0.016910547527581286 0.12297237551041694 0.24436368651830595 0.01234784440949523 0.03031450159425007 1.3020241288531288e-07 6.885380967433979 -0.26352674301119117 AGFSGGMVVDYPNSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGFSGGMVVDYPNSAK 16 0 O43709;O43709-3;H7C170 O43709 WBSCR22 Probable 18S rRNA (guanine-N(7))-methyltransferase 0 14341400.0 3264600.0 5416900.0 5659900.0 False True 4279922.21443137 4608719.63491082 5074267.841594479 1.0 1.0768232234153197 1.185598145799163 22.029153145886603 -6.966198177392305 0.3368545782596314 0.9877635262446576 1.2782555862750464 0.9999357512157421 0.0006103033250155449 0.07755667663172902 0.013439016792840737 0.0015507356676894386 0.009436982223896294 1.0809405835982175e-07 6.966198177392305 0.29049206003038885 AGFSGGMVVDYPNSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGFSGGMVVDYPNSAK 16 0 O43709;O43709-3;H7C170 O43709 WBSCR22 Probable 18S rRNA (guanine-N(7))-methyltransferase 0 8564100.0 1695200.0 1053000.0 5815900.0 False True 1641386.8039055648 1473468.3913224575 4292541.316739916 1.0 0.8976972324965954 2.6151918039831408 20.646483829088798 -6.892747795231739 1.0059645047124706 0.9137038892794549 2.7711291349791547 0.9826002803543304 0.10376294777804619 0.11694282849603758 0.2090410414386417 0.07829462900961444 0.197227324206671 1.2801244860000604e-07 6.892747795231739 1.8574252456996998 up AGFSGGMVVDYPNSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGFSGGMVVDYPNSAK 16 0 O43709;O43709-3;H7C170 O43709 WBSCR22 Probable 18S rRNA (guanine-N(7))-methyltransferase 0 8252000.0 3264600.0 2854300.0 2133100.0 False True 4471610.842497761 2728187.5880921185 1629305.7125734987 1.0 0.6101129289167306 0.36436661640783524 22.092363207409495 -8.585988919684116 0.17054160147017752 1.3870572274787871 1.0521958525992482e-05 0.9998251415361672 0.0034607035797934184 0.19573523276284777 0.04479572072444918 0.17679954102448045 0.1413280007082465 2.5942455492215184e-09 8.585988919684116 -1.387046705520261 down AGFSGGMVVDYPNSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGFSGGMVVDYPNSAK 16 0 O43709;O43709-3;H7C170 O43709 WBSCR22 Probable 18S rRNA (guanine-N(7))-methyltransferase 0 3007200.0 1695200.0 1312000.0 0.0 False True 1409633.9100933378 1304931.99558839 0.0 1.0 0.9257240381667499 0.0 20.426889104523074 -7.089223198763162 1.0025972579574376 1.0027786814251405 2.0603783268532836e-17 0.9892562925392586 0.047152189216449335 0.0844391938047906 0.16181490557159633 0.03865123855898977 0.06845128477026505 8.142856872461422e-08 7.089223198763162 -1.0027786814251405 down AGFSGGMVVDYPNSAK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGFSGGMVVDYPNSAKAK 18 1 O43709;O43709-3;H7C170 O43709 WBSCR22 Probable 18S rRNA (guanine-N(7))-methyltransferase 1 289634200.0 149001200.0 123920000.0 16713000.0 True False 144271238.46513346 173401902.23426294 12335363.920747282 1.0 1.2019159472050251 0.0855011993518612 27.104208475701917 -6.860083933347675 1.1852343337432298 1.1095814683707952 0.03133133653553479 0.953750962997087 0.104460508015053 0.14671530270545827 0.39157460044420905 0.06873664906805986 0.16047524472548916 1.3801175122443732e-07 6.860083933347675 -1.0782501318352604 down AGFSGGMVVDYPNSAK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGFSGGMVVDYPNSAKAK 18 1 O43709;O43709-3;H7C170 O43709 WBSCR22 Probable 18S rRNA (guanine-N(7))-methyltransferase 1 39405500.0 20898000.0 16843000.0 1664500.0 True False 28624555.347215075 16098820.567647254 1271379.3814535611 1.0 0.5624129483364545 0.044415690166424035 24.77074994682373 -7.748099514292282 0.5571134201616043 1.0106772127377632 3.618970481842291e-24 0.9926590924006347 0.033464179515681036 0.11515030241561987 0.1193641367941536 0.035362625957909524 0.07684040224912887 1.7860782657605017e-08 7.748099514292282 -1.0106772127377632 down AGGAAVVITEPEHTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGGAAVVITEPEHTK 15 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 42084900.0 9806100.0 18797800.0 13481000.0 False True 12855892.062407497 15993241.513250504 12086115.438883217 1.0 1.24403980957627 0.9401226597277353 23.615926385574024 -6.692933484614233 1.8560116900948276 1.1525742886859998 0.9411345978700776 0.3841992945235452 0.10315087394477578 0.41038379134926894 2.743109111480608 0.044423524115759574 0.1152551956738593 2.027993297787355e-07 6.692933484614233 -0.21143969081592218 AGGAAVVITEPEHTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGGAAVVITEPEHTK 15 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 26739290.0 7031400.0 3534690.0 16173200.0 False True 6808192.055793766 4946110.15016484 11936953.734400177 1.0 0.7264939222676164 1.7533221208473164 22.698840304649032 -6.835835692235954 1.3014798744008118 0.8543311613925961 1.7844280141447044 0.9170743508629852 0.12503241960324377 0.1737182724292568 0.5733593754786367 0.0753763969452097 0.17351737770170403 1.4593662816965196e-07 6.835835692235954 0.9300968527521083 AGGAAVVITEPEHTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGGAAVVITEPEHTK 15 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 65158300.0 2090700.0 57527000.0 5540600.0 False True 3171744.7506435257 47260857.38949746 4445497.981468748 1.0 14.900586618739906 1.4015938642498853 21.59684524269964 -6.632357528796615 2.0721569781584814 9.999999377626756 1.456672151376667 0.1586153985158738 5.925770455766608 0.5360126768943115 4.389082433147291 2.3461092965860457 6.589340370388505 2.331537855656169e-07 6.632357528796615 -8.543327226250089 AGGAAVVITEPEHTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGGAAVVITEPEHTK 15 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 38435700.0 9806100.0 13114500.0 15515100.0 False True 13431680.169888306 12535058.026147945 11850752.92351466 1.0 0.9332457196419517 0.8822986233756642 23.679136447096916 -6.974125652919724 0.12511068122938523 1.0848602146812678 0.7293703080037732 0.9999993250465259 3.917218675156793e-05 0.07498518274912655 0.0037408376786611554 0.0033848367833804087 0.00713962145835172 1.0613884249296885e-07 6.974125652919724 -0.3554899066774946 AGGAAVVITEPEHTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGGAAVVITEPEHTK 15 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 11327260.0 7031400.0 2806360.0 1489500.0 False True 5846920.643835712 2791241.581661152 1800947.5633301297 1.0 0.4773866025706883 0.3080164197591482 22.479245580083308 -13.999999999999998 0.15758281857387552 3.5610879296247218 0.13699534861531185 0.9995429362181001 0.0062964504241993175 11.994444462098963 0.125361369244753 9.391407842797625 0.1554112569691318 1.0000000000000041e-14 13.999999999999998 -3.42409258100941 AGGAAVVITEPEHTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGGAAVVITEPEHTK 15 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 9121200.0 2090700.0 4822100.0 2208400.0 False True 2706452.3638582127 4553745.896033425 1806493.860097539 1.0 1.6825516520607748 0.6674766880146643 21.36797156479209 -6.725551536610806 1.739295202738185 1.4127893120888895 0.6685465204903341 0.5384978909289891 0.2870449918744439 0.3446919564285165 2.0406553273008026 0.13089203987384185 0.3264674989221914 1.881258448863282e-07 6.725551536610806 -0.7442427915985553 AGGAAVVITEPEHTK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGGAAVVITEPEHTKER 17 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 6725750.0 1597700.0 4164500.0 963550.0 True False 2094600.1721488107 3543172.8330938546 863851.0890242511 1.0 1.6915747836776795 0.4124181313983387 20.998243450619352 -6.759855936856211 1.6128916215447224 1.4017739299167042 0.40775770436936193 0.6904326611831086 0.29087309451914173 0.28315590123451434 1.4517305699275564 0.14229041924241903 0.3420114415300532 1.7383773835732482e-07 6.759855936856211 -0.9940162255473424 AGGAAVVITEPEHTK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGGAAVVITEPEHTKER 17 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 9587300.0 3959600.0 1646300.0 3981400.0 True False 3833904.665375463 2303676.1753410855 2938551.900560237 1.0 0.6008694467929554 0.7664645203879783 21.870383032438724 -10.157442945356962 5.287437740750651 1.0000110962581827 0.6836669835903224 0.829513334008303 0.06760390570491119 8.843165859544111e-06 1.4092862962299568e-06 0.06545949415632854 0.02181906674440187 6.959163734359017e-11 10.157442945356962 -0.31634411266786033 AGGAAVVITEPEHTK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGGAAVVITEPEHTKER 17 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 4460300.0 1597700.0 1184600.0 1678000.0 True False 2188412.8662190414 1132260.455051651 1281690.9594947877 1.0 0.517388867763274 0.5856714604813977 21.061453512142243 -10.550405059389199 6.33041071705474 1.0006391644434638 0.5515301641224217 0.9829105220115726 0.02787625174561425 0.000251803272016279 1.7883390844435366e-05 0.027027178209575262 0.00899702156378746 2.815755496885217e-11 10.550405059389199 -0.44910900032104206 AGGAAVVITEPEHTK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGGAAVVITEPEHTKER 17 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 9530800.0 3959600.0 2794400.0 2776800.0 True False 3292582.840022174 2779346.012555028 3357416.041527429 1.0 0.84412333647961 1.0196906819525362 21.650788307873 -6.672466046504948 1.9288157802056345 0.9007159578708898 1.0189865874379036 0.2899742301598355 0.06617563067948204 0.455456443162226 3.2691057072507075 0.02759884893447712 0.07349593539909144 2.1258565399099568e-07 6.672466046504948 0.11827062956701384 AGGALCHILGAAYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGGALCHILGAAYK 14 0 Q92922;F8WE13 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 0 23903100.0 6176400.0 6164700.0 11562000.0 False True 8097320.21234268 5244950.7898123935 10365675.150535412 1.0 0.6477390855579056 1.2801364993241957 22.949013100033287 -6.755534556440238 1.629390129383788 0.7942544621096247 1.2819420993856165 0.6724376421741836 0.14808153675235722 0.29048172738436695 1.5188882361414362 0.07174521767548471 0.17317622391853987 1.7557611842261408e-07 6.755534556440238 0.48768763727599185 AGGALCHILGAAYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGGALCHILGAAYK 14 0 Q92922;F8WE13 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 0 20860100.0 6176400.0 10406000.0 4277700.0 False True 8459981.990934012 9946228.511959694 3267395.361996937 1.0 1.1756796317791682 0.3862177680163365 23.01222316155618 -6.848303639068553 1.243128116056714 1.0936371110695617 0.35565597376674946 0.9378124117551775 0.08439693075648359 0.1593374439931779 0.47467498522442647 0.053144504964386725 0.12286261428304301 1.418065727570607e-07 6.848303639068553 -0.7379811373028122 down AGGALCHILGAAYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGGALCHILGAAYK 14 0 Q92922;F8WE13 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 0 8962300.0 4902600.0 1664600.0 2395100.0 False True 4076729.1220054245 1655632.4694027689 2895904.336308819 1.0 0.40611785081966156 0.7103499520429911 21.958980669559434 -10.549081079826298 6.477151573492516 1.000530300689069 0.5582339014313535 0.7376251137265447 0.12420223522865323 0.0009522068014704288 6.628962144465393e-05 0.12039509809129027 0.0400860990501925 2.824352638261953e-11 10.549081079826298 -0.44229639925771536 AGGEPWGAK(ub)KPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGGEPWGAKKPR 12 2 Q8N163;Q8N163-2;E5RHJ4 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 1 3599380.0 1258600.0 1685600.0 655180.0 True False 1046581.6654338572 1676519.338234596 792175.1087899515 1.0 1.6019001608819508 0.7569166697197565 19.997253459722955 -6.715404311920134 1.7756676582808155 1.367965662803299 0.7585426484269847 0.4908634078853591 0.25343388813923234 0.3643067182785942 2.2422102260150303 0.11343510225063606 0.28633517379791706 1.925731294611215e-07 6.715404311920134 -0.6094230143763143 AGGK(ub)HNDLDDVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGGKHNDLDDVGK 13 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 3173530.0 642230.0 1066500.0 1464800.0 True False 841969.7493641679 907382.3571844401 1313236.547353767 1.0 1.0776899738614956 1.5597193941296428 19.68340887491816 -6.9351293449922995 0.7034127261092331 0.99387520513121 1.672979543500058 0.9974538589081137 0.012492839158345106 0.09006037987799884 0.06526393593344536 0.011751505077516714 0.0424528230401706 1.1611027536014561e-07 6.9351293449922995 0.6791043383688481 AGGK(ub)HNDLDDVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGGKHNDLDDVGK 13 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 4480310.0 828610.0 1157300.0 2494400.0 True False 802306.2291081834 1619415.9252397714 1841041.809604025 1.0 2.0184511430752066 2.29468716907566 19.613793472827087 -10.477597510711083 0.2789704928673915 7.80393209155497e-23 2.403470198047484 0.99908900916944 0.01680426224973344 2.0643590213568452 0.13590610761423774 1.568267285940957 0.10858195192550132 3.329679937072079e-11 10.477597510711083 2.403470198047484 AGGK(ub)HNDLDDVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGGKHNDLDDVGK 13 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 3302370.0 828610.0 894360.0 1579400.0 True False 689025.9286470285 889541.9051634388 1909645.2376794936 1.0 1.2910136878450182 2.7715143339079757 19.394198748261363 -6.939419283925055 0.6649427493430716 0.9832041061868005 3.1640307386470763 0.998086862043537 0.033926922231801805 0.0880325376149081 0.05582334124766048 0.03288180422970387 0.1277532076815087 1.1496898999063138e-07 6.939419283925055 2.180826632460276 up AGGK(ub)ILTFDQLALDSPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGGKILTFDQLALDSPK 17 1 J3QQ67;Q07020;G3V203;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 8629600.0 1750900.0 4247500.0 2631200.0 True False 2295446.855739717 3613789.5566253248 2358948.6642526174 1.0 1.5743294372462249 1.0276642468781692 21.13034360043858 -10.321928485154045 3.7613733417070283 0.9991593393992868 1.3009968421270732 0.2878618075255268 0.22317512968500042 160017743.26107243 233245744.14216968 1475294.261804402 0.08167374726454414 4.765094466880433e-11 10.321928485154045 0.3018375027277864 AGGK(ub)ILTFDQLALDSPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGGKILTFDQLALDSPK 17 1 J3QQ67;Q07020;G3V203;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 19251900.0 5347400.0 6462900.0 7441600.0 True False 5177649.714018779 9043569.673578251 5492421.716785318 1.0 1.7466553693449511 1.0607943797190984 22.303865934534745 -10.231726403214623 5.314027720150333 0.999966623365996 1.4037248745320807 0.31600326905972065 0.28000157651083546 0.00011073360667345782 1.6009191294829114e-05 0.27113272960914475 0.09037012022815774 5.865075361003977e-11 10.231726403214623 0.40375825116608477 AGGK(ub)ILTFDQLALDSPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGGKILTFDQLALDSPK 17 1 J3QQ67;Q07020;G3V203;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 20678300.0 4864800.0 4484500.0 11329000.0 True False 7380257.264519365 3684205.937441573 9089818.18432291 1.0 0.4991974948018977 1.2316397462216218 22.815239676636576 -6.722616372052836 1.749628771431546 0.6961819207082376 1.2306925587693127 0.5249888689132023 0.21067403796648465 0.3502428969698103 2.09667079719488 0.09555099779922253 0.23915839970616304 1.8940159323720178e-07 6.722616372052836 0.5345106380610751 AGGK(ub)ILTFDQLALDSPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGGKILTFDQLALDSPK 17 1 J3QQ67;Q07020;G3V203;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 9957700.0 1750900.0 3263900.0 4942900.0 True False 2398255.0462933667 3119690.1057260525 3775488.822220977 1.0 1.3008166544036686 1.574264934022009 21.19355366196147 -6.972262050255452 0.1967958556888192 0.8303532108411174 2.0522522732587634 0.9999950677068526 0.0005208333335425148 0.07557533526467464 0.006329421944097949 0.009116574699734564 0.029269609333861725 1.065952738710053e-07 6.972262050255452 1.221899062417646 AGGK(ub)ILTFDQLALDSPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGGKILTFDQLALDSPK 17 1 J3QQ67;Q07020;G3V203;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 15242700.0 5347400.0 6441700.0 3453600.0 True False 4446600.029986508 6406997.28352266 4175731.7923577884 1.0 1.4408755544271654 0.9390841911118456 22.08427120996902 -6.674655871963649 1.9205943769257947 1.2802772464526129 0.9410559136089244 0.2998552803420561 0.18707654395566375 0.45057314002942545 3.2084172399680693 0.07828921925032226 0.2079283464301585 2.1151643985951303e-07 6.674655871963649 -0.3392213328436885 AGGK(ub)ILTFDQLALDSPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGGKILTFDQLALDSPK 17 1 J3QQ67;Q07020;G3V203;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 10768500.0 4864800.0 0.0 5903700.0 True False 6297579.499544384 0.0 4829287.177077449 1.0 0.0 0.7668481481538799 22.586365998729026 -10.828792383219893 9.858630324824102 1.0126506826335948 0.3834240747489263 0.4629349724211006 0.31306444552920065 0.08206745516239561 0.0014252028836504206 0.2857748228462305 0.10104111531868779 1.483226980210268e-11 10.828792383219893 -0.6292266078846684 AGGPTTPLSPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGGPTTPLSPTR 12 0 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 0 5056180.0 1553500.0 417580.0 3085100.0 False True 1504184.992842907 584321.8716509321 2277019.758983873 1.0 0.38846410144444055 1.5137897065973975 20.52055057772583 -6.759128483963956 1.6157634323980559 0.6444022922666381 1.5177234852310204 0.687402398074979 0.2571821461760229 0.28438029896107864 1.4630603351042129 0.1255993352306076 0.3020937940486927 1.7412916443019239e-07 6.759128483963956 0.8733211929643823 AGGSASAMLQPLLDNQVGFK ddPTM_RPMI8226_Bortezomib_1h_R1 2 AGGSASAMLQPLLDNQVGFK 20 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 25239400.0 3933700.0 13545200.0 7760500.0 False True 5157118.794004994 11524308.95877607 6957517.903972498 1.0 2.234640972818535 1.3491094895972566 22.29813384766099 -10.154906201130876 4.696864832010308 0.9999150104865708 1.7918752312150288 0.5160229458807244 0.36151671420146836 0.0003217728572569589 5.78959656380179e-05 0.3500743123970444 0.1166790177863642 6.999931641150864e-11 10.154906201130876 0.791960220728458 AGGSASAMLQPLLDNQVGFK ddPTM_RPMI8226_Bortezomib_2h_R1 2 AGGSASAMLQPLLDNQVGFK 20 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 38929100.0 14801700.0 5354900.0 18772500.0 False True 14331828.135540962 7493139.495434589 13855419.087071663 1.0 0.5228320786831537 0.9667586686106101 23.772719312461895 -10.53679996180629 9.222836001373105 1.0000136417647187 0.744795373646882 0.30586874671034814 0.18123227142933643 5.0838863053005286e-05 2.5533297497418844e-06 0.1754867572445839 0.05849246408676352 2.9053605698129434e-11 10.53679996180629 -0.25521826811783677 AGGSASAMLQPLLDNQVGFK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AGGSASAMLQPLLDNQVGFK 20 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 25604900.0 3933700.0 11750000.0 9921200.0 False True 5388095.194245381 11230846.147946032 7578016.893527823 1.0 2.084381538013815 1.406437084040633 22.36134390918388 -10.099474896687699 4.828126194132855 0.9999665401576635 1.7454093110336701 0.6171380616442089 0.27676966438623185 9.969263268747365e-05 1.859517144831649e-05 0.2679930690105002 0.08932702507211286 7.952892339208742e-11 10.099474896687699 0.7454427708760066 AGGSASAMLQPLLDNQVGFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGGSASAMLQPLLDNQVGFK 20 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 14588100.0 9222000.0 2897300.0 2468800.0 False True 7668501.603870195 2881691.669830975 2985014.6655585268 1.0 0.3757828867606446 0.3892565744593478 22.870513277450193 -10.074035340070456 5.414524998776075 1.0000059836213138 0.3825197306095734 0.9996430285631346 0.005500609970724269 3423877.3125290177 6370321.080213687 174.14725335031036 0.0018830048063865575 8.432661354390478e-11 10.074035340070456 -0.6174862530117404 AGGSASAMLQPLLDNQVGFK(ub)NMQNVEHVPLSLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDR 34 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 20668200.0 14515000.0 4321900.0 1831300.0 True False 14054229.27010929 6047657.208410757 1351627.592177617 1.0 0.43030870581234854 0.09617230274251148 23.744501003118014 -8.481093051093591 0.3664518764471847 1.1180814445703238 1.135717657546327e-16 0.9976383956827117 0.018133228028954156 0.17530605875578795 0.10708478327716024 0.10154659835074811 0.08450377707916422 3.3029876428205806e-09 8.481093051093591 -1.1180814445703235 AGGSASAMLQPLLDNQVGFK(ub)NMQNVEHVPLSLDR ddPTM_RPMI8226_Bortezomib_8h_R1 2 AGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDR 34 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 861217000.0 33644000.0 155465000.0 672108000.0 True False 51040407.705864444 127721056.09641089 539265559.2045983 1.0 2.5023518000177725 10.565463393479863 25.605136517469482 -6.938238453792301 0.6757538410548906 0.9061428547524164 12.631587347196875 0.9979239290091265 0.1913738480871033 0.0885796092942784 0.058338980160343765 0.18388945981078253 0.6995336378432956 1.1528201164374526e-07 6.938238453792301 11.72544449244446 AGGSASAMLQPLLDNQVGFK(ub)NMQNVEHVPLSLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDR 34 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 90946400.0 23293400.0 33805000.0 33848000.0 True False 19369494.17258621 33622885.75523286 40925460.304530546 1.0 1.735868033292247 2.112882243587582 24.20728294317955 -9.766091261040177 0.16548426274766076 1.2754062963718521e-12 2.6046012189519216 0.9996684237847602 0.008415187197943371 1.255670239167849 0.0718441806275885 0.8589501865941955 0.28496557900453806 1.713597180682343e-10 9.766091261040177 2.6046012189506462 AGGSASAMLQPLLDNQVGFK(ub)NMQNVEHVPLSLDR ddPTM_RPMI8226_Carfilzomib_8h_R1 3 AGGSASAMLQPLLDNQVGFKNMQNVEHVPLSLDR 34 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 956803800.0 38009400.0 144668400.0 774126000.0 True False 49203917.57728635 136617476.36625573 633243011.2035258 1.0 2.7765568900416473 12.869768148214385 25.552269850595536 -6.937000603270666 0.6868987213633013 0.878702995214864 15.367122554862876 0.997744079768982 0.2482778347736069 0.08916200181112362 0.06104263603468645 0.2365042557924609 0.8807938012833861 1.1561106362584602e-07 6.937000603270666 14.488419559648012 AGGSLCHILAAAYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGGSLCHILAAAYK 14 0 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3;F8VZW6 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 0 20080300.0 5307700.0 5988000.0 8784600.0 False True 6958446.099839914 5094613.741041184 7875653.859833369 1.0 0.7321481934247348 1.131812152718199 22.730333741152986 -6.726096157891962 1.73732886185444 0.8381137480891828 1.1314163120620182 0.5411536813340828 0.11263710185526997 0.3435970940885267 2.0298445228456203 0.051415493948617136 0.12815840666636055 1.8789007600798824e-07 6.726096157891962 0.2933025639728354 AGGSLCHILAAAYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGGSLCHILAAAYK 14 0 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3;F8VZW6 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 0 16999200.0 5307700.0 4735000.0 6956500.0 False True 7270100.12519922 4525792.043448892 5313517.97361472 1.0 0.6225212810703723 0.7308727365662128 22.793543802675877 -10.338425023135787 8.388570869383859 1.0000009118872513 0.6766970088182934 0.9223061852442018 0.04423429647544821 7.544004062719005e-07 5.949577070849335e-08 0.042829794004074356 0.014276557798384368 4.5874883764124144e-11 10.338425023135787 -0.32330390306895784 AGHCAVAINTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGHCAVAINTR 11 0 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 5792300.0 1485200.0 1798500.0 2508600.0 False True 1947111.582697257 1530170.810498093 2249034.1361903767 1.0 0.7858670371517218 1.1550617623438295 20.892904131960336 -6.749497309174058 1.652050794094309 0.8740075016536314 1.155751365357321 0.6466399794676925 0.08997745366888435 0.30093502469892963 1.6158796297630202 0.04303018455714609 0.10450669082096826 1.7803389395427274e-07 6.749497309174058 0.28174386370368965 AGHCAVAINTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGHCAVAINTR 11 0 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 5129100.0 1485200.0 1349400.0 2294500.0 False True 2034318.576020851 1289779.046130927 1752586.3567108428 1.0 0.6340103567523572 0.8615102754156237 20.956114193483227 -10.33993055948918 6.019847488019553 1.0000268099528464 0.7477603160839902 0.6210816553785101 0.09287645287494732 3.342223319102152e-05 3.6645579229761573e-06 0.0899367854210978 0.029975746269957273 4.5716128051601884e-11 10.33993055948918 -0.25226649386885625 AGHQFGVTWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGHQFGVTWR 10 0 Q96EY7 Q96EY7 PTCD3 Pentatricopeptide repeat domain-containing protein 3, mitochondrial 0 31455100.0 8940100.0 5719000.0 16796000.0 False True 11720557.67605154 4865747.492487402 15058111.038608609 1.0 0.4151464142725494 1.2847606278476533 23.482537880501805 -6.725488887767977 1.739392672797882 0.6462864558697465 1.2838586682847393 0.5383486032494035 0.245958073959543 0.3447660035745528 2.0412659460431266 0.112149207784889 0.27975358243757015 1.8815298480429008e-07 6.725488887767977 0.6375722124149927 AGHQFGVTWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGHQFGVTWR 10 0 Q96EY7 Q96EY7 PTCD3 Pentatricopeptide repeat domain-containing protein 3, mitochondrial 0 17144100.0 6282200.0 1685100.0 9176800.0 False True 6082774.999702416 2357969.217680413 6773120.781901131 1.0 0.3876469568241091 1.1134919148304003 22.536298209599025 -6.682985872706679 1.8907533034435187 0.6136234221032567 1.110836163195739 0.33814997048769746 0.25935801731265024 0.4318809722246935 2.9874483729586174 0.10995221020325677 0.28894272255050923 2.0749810140266323e-07 6.682985872706679 0.49721274109248237 AGHQFGVTWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGHQFGVTWR 10 0 Q96EY7 Q96EY7 PTCD3 Pentatricopeptide repeat domain-containing protein 3, mitochondrial 0 10331300.0 3477900.0 2875900.0 3977500.0 False True 5276228.56854791 2362673.1754907393 3191345.3815998165 1.0 0.4477958346184724 0.6048535123409405 22.33107563345266 -10.689174673096467 10.2282763800539 1.0003135258931248 0.5263246734797646 0.9238257564525241 0.06411852843442196 0.0004586962349760187 1.3939223484688002e-05 0.06212020207187937 0.020694166067486922 2.0456217228699888e-11 10.689174673096467 -0.4739888524133602 AGHQFGVTWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGHQFGVTWR 10 0 Q96EY7 Q96EY7 PTCD3 Pentatricopeptide repeat domain-containing protein 3, mitochondrial 0 28758400.0 8940100.0 6967300.0 12851000.0 False True 12245496.56711824 6659461.648219961 9815858.474652875 1.0 0.5438294487870774 0.8015892553520892 23.545747942024697 -10.161351773151539 5.446767241521856 1.0000088513987668 0.6727093520695195 0.6825082859142035 0.10523000038068778 1.1311018530654549e-05 1.7416905595970455e-06 0.10189126263604016 0.03396283658295097 6.896809445129768e-11 10.161351773151539 -0.3272994993292473 AGHQFGVTWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGHQFGVTWR 10 0 Q96EY7 Q96EY7 PTCD3 Pentatricopeptide repeat domain-containing protein 3, mitochondrial 0 14113800.0 6282200.0 3712800.0 4118800.0 False True 5223927.648648162 3692798.409466902 4980022.0368204955 1.0 0.7069007570237916 0.9533099177032468 22.3167034850333 -10.063828962404402 6.59445941473662 1.0000001139299268 0.8301053378807816 0.38794762345014855 0.10059611860202464 1.6852060957729662e-07 2.388020712635546e-08 0.09740183759670504 0.03246725766989539 8.633184803489663e-11 10.063828962404402 -0.16989477604914527 AGHQFGVTWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGHQFGVTWR 10 0 Q96EY7 Q96EY7 PTCD3 Pentatricopeptide repeat domain-containing protein 3, mitochondrial 0 15308400.0 3477900.0 7860500.0 3970000.0 False True 4502210.109658238 7423056.265065172 3247500.7356399316 1.0 1.6487582952072966 0.7213125679482003 22.10220195554511 -6.71866797821331 1.7642946558784167 1.3952584012003233 0.7228828102129374 0.5061622278152016 0.27304499334835997 0.35790057597210506 2.176530434634098 0.12292270262458921 0.30904473567884494 1.9113139157280506e-07 6.71866797821331 -0.6723755909873859 AGHYAASIIIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGHYAASIIIR 11 0 P55263;P55263-3;P55263-4;P55263-2;A0A5F9ZHJ1 P55263 ADK Adenosine kinase 0 45718000.0 13718000.0 11741000.0 20259000.0 False True 17984430.845300984 9989288.566059548 18162793.01805024 1.0 0.5554409061919007 1.0099175878449251 24.100245167323717 -10.939382401872933 11.293178314515021 1.0449299418371594 0.7826792470184193 0.23364146733406732 0.18553932834053655 0.10726838678508424 0.0005757762505181812 0.09181283898846042 0.05988256072745066 1.1497875403902351e-11 10.939382401872933 -0.2622506948187401 AGHYAASIIIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGHYAASIIIR 11 0 P55263;P55263-3;P55263-4;P55263-2;A0A5F9ZHJ1 P55263 ADK Adenosine kinase 0 34632500.0 14160000.0 5301500.0 15171000.0 False True 13710498.550792132 7418416.596957272 11197259.979755703 1.0 0.5410756267888354 0.8166924009564025 23.70877769657435 -10.31311026441799 5.842709134729813 1.0000311433261506 0.6788840138726183 0.6441137165323885 0.11252007687707787 4.565116699174272e-05 5.367016315117892e-06 0.10895764266197165 0.036315698654907844 4.862837258830056e-11 10.31311026441799 -0.3211471294535323 AGHYAASIIIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGHYAASIIIR 11 0 P55263;P55263-3;P55263-4;P55263-2;A0A5F9ZHJ1 P55263 ADK Adenosine kinase 0 61180000.0 16150000.0 20954000.0 24076000.0 False True 24500730.72315157 17214594.985650748 19317368.047114328 1.0 0.7026155742115926 0.7884404863427479 24.546321441804533 -10.141511551547941 7.312941212730898 1.0000001341418825 0.7455280302771704 0.9213943685526536 0.03503787365675545 7.661523475659821e-08 8.986596251289453e-09 0.033925293488551625 0.01130842509659445 7.219189607765534e-11 10.141511551547941 -0.2544721038647121 AGHYAASIIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGHYAASIIIR 11 0 P55263;P55263-3;P55263-4;P55263-2;A0A5F9ZHJ1 P55263 ADK Adenosine kinase 0 44454000.0 13718000.0 14819000.0 15917000.0 False True 18789915.31501083 14164247.580120195 12157732.420904974 1.0 0.7538217891170964 0.647034976852314 24.16345522884661 -13.999999999843219 0.1137320655854751 2.180993594094011 0.4612583972505843 0.9997241651182367 0.0024546209786579917 11.992002107170157 0.102926485704614 3.2309042111001434 0.16489015306550403 1.0000000003610022e-14 13.999999999843219 -1.7197351968434265 AGHYAASIIIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGHYAASIIIR 11 0 P55263;P55263-3;P55263-4;P55263-2;A0A5F9ZHJ1 P55263 ADK Adenosine kinase 0 24760900.0 14160000.0 4530700.0 6070200.0 False True 11774667.39436154 4506292.219826461 7339450.754566326 1.0 0.3827107865470884 0.6233255266370344 23.489182972008628 -10.266023122652657 5.6085128639286355 1.000038003339743 0.5030181565920715 0.8504830762147426 0.09823055630216686 4.668213151421649e-05 6.109062183559318e-06 0.09511857688645235 0.03170377572057607 5.419720340259857e-11 10.266023122652657 -0.4970198467476714 AGHYAASIIIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGHYAASIIIR 11 0 P55263;P55263-3;P55263-4;P55263-2;A0A5F9ZHJ1 P55263 ADK Adenosine kinase 0 88032000.0 16150000.0 46114000.0 25768000.0 False True 20906493.36409345 43547715.36253619 21078488.40200748 1.0 2.082975590604241 1.0082268716670308 24.317447763896983 -6.644431997356111 2.02863360302732 1.7058205394879526 1.0127424819728925 0.171732811230614 0.46286506190870397 0.5222920741880998 4.113344392033658 0.1854673402640278 0.512528831337923 2.2676081156766354e-07 6.644431997356111 -0.6930780575150601 AGIATHFVDSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGIATHFVDSEK 12 0 Q6NVY1;Q6NVY1-2;H7C400 Q6NVY1 HIBCH 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial 0 5415800.0 1244300.0 1194900.0 2976600.0 False True 1631289.3498183412 1016625.5776837207 2668609.985563373 1.0 0.623203711712414 1.6358900313182005 20.637581271989426 -6.805932822825087 1.4314781347950787 0.7936483867476815 1.6520223960761962 0.8489916669860914 0.1624003067810838 0.21237989506423258 0.8584399432825222 0.08922492037291133 0.20680958966421836 1.563389450835088e-07 6.805932822825087 0.8583740093285147 AGIATHFVDSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGIATHFVDSEK 12 0 Q6NVY1;Q6NVY1-2;H7C400 Q6NVY1 HIBCH 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial 0 5076150.0 1244300.0 1441700.0 2390150.0 False True 1704351.335943138 1378000.9269356441 1825645.796684426 1.0 0.8085192870008219 1.0711675217329337 20.700791333512317 -6.711229375686361 1.790637011848734 0.8824280125850265 1.0705768626072456 0.4709355503269109 0.08067405076316338 0.3726561130280592 2.3299222639717336 0.035841134207937865 0.09092416370825543 1.9443328972889824e-07 6.711229375686361 0.18814885002221915 AGICHK(ub)VSTFAMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGICHKVSTFAMR 13 1 Q68D91 Q68D91 MBLAC2 Metallo-beta-lactamase domain-containing protein 2 1 21083600.0 6713400.0 10927000.0 3443200.0 True False 8801332.412658079 9296734.193112392 3086930.693506622 1.0 1.0562871344049938 0.35073447391522194 23.069290515758578 -6.887595895788476 1.0365293006849898 1.0401239823453736 0.29284000646069713 0.9793132666866907 0.04604815636174464 0.12111418171255108 0.23343050733573645 0.033952738835891456 0.08394199107239152 1.2954006308367968e-07 6.887595895788476 -0.7472839758846765 down AGICHK(ub)VSTFAMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGICHKVSTFAMR 13 1 Q68D91 Q68D91 MBLAC2 Metallo-beta-lactamase domain-containing protein 2 1 9628600.0 5333400.0 2497000.0 1798200.0 True False 5164094.136355554 3494065.1216829782 1327197.4751563317 1.0 0.6766075577678834 0.25700489574982305 22.300083869120222 -7.260453304933378 0.36884349168482133 1.0408774146846103 1.2726903197836057e-12 0.9997062721708437 0.005213062209179902 0.09741198165321456 0.025835903364170132 0.010608703837122027 0.04774823913814827 5.4896757707893205e-08 7.260453304933378 -1.0408774146833375 down AGICHK(ub)VSTFAMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGICHKVSTFAMR 13 1 Q68D91 Q68D91 MBLAC2 Metallo-beta-lactamase domain-containing protein 2 1 39081000.0 11509000.0 13262000.0 14310000.0 True False 17459994.420603797 10895292.483521046 11481622.227704193 1.0 0.6240146600885493 0.6575959849194006 24.05754976216122 -9.951419344770649 5.993831297923255 1.0000001863435846 0.6408053229708782 0.9934873230512686 0.013709518454001696 3.4138161006098524e-08 5.973136858401016e-09 0.013274191087026918 0.004424728054696137 1.1183575016539739e-10 9.951419344770649 -0.35919486337270634 AGICHK(ub)VSTFAMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGICHKVSTFAMR 13 1 Q68D91 Q68D91 MBLAC2 Metallo-beta-lactamase domain-containing protein 2 1 16532600.0 6713400.0 4848900.0 4970300.0 True False 9195525.402813356 4634659.56483196 3796417.5065416875 1.0 0.5040124801801965 0.4128548767186462 23.13250057728147 -13.999999999999993 0.23823141404738027 4.255055280148394 0.37186746887521904 0.9995220731280974 0.005640164445620294 13.561670543480004 0.1544908474279608 20.97914668848695 0.045010762447860946 1.0000000000000164e-14 13.999999999999993 -3.883187811273175 AGICHK(ub)VSTFAMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGICHKVSTFAMR 13 1 Q68D91 Q68D91 MBLAC2 Metallo-beta-lactamase domain-containing protein 2 1 10853800.0 5333400.0 2624300.0 2896100.0 True False 4434958.409681338 2610162.3750172365 3501661.119946553 1.0 0.5885426950835335 0.7895589533156762 22.080489144554498 -10.100007266376252 5.084485011669629 1.0000082544812707 0.6890508241988377 0.7613635013033763 0.08206454378138257 7.6789876711766e-06 1.3593368215224513e-06 0.0794607608706823 0.026486217614567643 7.943149445726076e-11 10.100007266376252 -0.31095743028243306 AGICHK(ub)VSTFAMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGICHKVSTFAMR 13 1 Q68D91 Q68D91 MBLAC2 Metallo-beta-lactamase domain-containing protein 2 1 31907900.0 11509000.0 9605900.0 10793000.0 True False 14898627.376306592 9071323.220735257 8828784.74553194 1.0 0.6088697295135695 0.5925904798164446 23.82867608425367 AGIGVYWGPGHPLNVGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGIGVYWGPGHPLNVGIR 18 0 O60930 O60930 RNASEH1 Ribonuclease H1 0 16620200.0 6381300.0 5906900.0 4332000.0 False True 6178729.124447014 8265555.974076558 3197319.2427856904 1.0 1.3377437022401126 0.5174719879101101 22.55887869638493 -6.794899729568405 1.4766327435875846 1.1875743674875237 0.5075251390554528 0.8168070848738963 0.1440721015299577 0.2281369599012461 0.9825079304705469 0.07677582005197553 0.17913633362699422 1.603615592646128e-07 6.794899729568405 -0.6800492284320708 AGIGVYWGPGHPLNVGIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGIGVYWGPGHPLNVGIR 18 0 O60930 O60930 RNASEH1 Ribonuclease H1 0 87521000.0 26040000.0 28743000.0 32738000.0 False True 39504583.779001005 23613587.079915967 26267319.950424865 1.0 0.5977429660319056 0.6649182813156858 25.23551672538888 -10.678832847641411 6.706956713710027 1.002585728220777 0.6313306236738049 0.9757045519760819 0.027424207625974268 0.0010660738653693463 5.1049638537598934e-05 0.026697015181667283 0.008851124951527733 2.0949185982743314e-11 10.678832847641411 -0.3712551045469722 AGIGVYWGPGHPLNVGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGIGVYWGPGHPLNVGIR 18 0 O60930 O60930 RNASEH1 Ribonuclease H1 0 13812400.0 1253500.0 2622000.0 9936900.0 False True 1716952.824563789 2506151.37020549 7590008.876879475 1.0 1.4596506871656219 4.42062750256857 20.71141896934979 -6.934350182636806 0.7101735427365162 0.9614140656382429 5.101824570659441 0.9973263328726902 0.0783792144284281 0.09044101602038374 0.06706934077212376 0.07335472355740143 0.26180536757028394 1.1631877434507794e-07 6.934350182636806 4.140410505021198 up AGIGVYWGPGHPLNVGIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGIGVYWGPGHPLNVGIR 18 0 O60930 O60930 RNASEH1 Ribonuclease H1 0 13272600.0 6381300.0 2335000.0 4556300.0 False True 5306333.689522543 2322420.8915387895 5509001.264049057 1.0 0.43766959023411095 1.0381935223799974 22.339283971819206 -11.837774980118251 14.089277511448064 0.9136837281276005 0.7641384006763818 0.0 0.2812583557034108 0.0 0.0 0.0 0.08163961081832227 1.4528641913891998e-12 11.837774980118251 -0.14954532745121862 AGIGVYWGPGHPLNVGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGIGVYWGPGHPLNVGIR 18 0 O60930 O60930 RNASEH1 Ribonuclease H1 0 74410000.0 26040000.0 24786000.0 23584000.0 False True 33709293.32513888 23406637.31135493 19291953.992275074 1.0 0.6943674874934062 0.5723037207038689 25.00664304748133 -13.999999999999979 0.12659993304716663 2.4524766923203307 0.3937441334209788 0.9996612685018023 0.0033107591473503354 11.94329330541197 0.11029767184499614 4.330828549284451 0.15862561953572915 1.000000000000049e-14 13.999999999999979 -2.0587325588993517 AGIIASAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGIIASAR 8 0 P13639 P13639 EEF2 Elongation factor 2 0 76948000.0 19513000.0 22519000.0 34916000.0 False True 25581731.964160822 19159252.978374496 31303227.257921986 1.0 0.7489427613898851 1.2236555093993164 24.60861060675474 -6.763014118186991 1.6009718588521507 0.854716233903441 1.2256607539379527 0.7031611097271145 0.1056468875426815 0.2779077697101816 1.4045032901795114 0.05204774945583154 0.12471718472766626 1.7257817887997404e-07 6.763014118186991 0.3709445200345117 AGIIASAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGIIASAR 8 0 P13639 P13639 EEF2 Elongation factor 2 0 37684000.0 9744600.0 6318400.0 21621000.0 False True 9435263.006924361 8841370.070020726 15957811.483903382 1.0 0.9370560273234791 1.6912948237046754 23.169631302676873 -6.886637891869871 1.0420454999882207 0.9561477501628693 1.7520540264323166 0.9786584417334122 0.04991564383334494 0.12191430930278672 0.23811133896236936 0.036649341538508726 0.09033036052410638 1.298261290343214e-07 6.886637891869871 0.7959062762694472 AGIIASAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGIIASAR 8 0 P13639 P13639 EEF2 Elongation factor 2 0 66484000.0 12680000.0 43300000.0 10504000.0 False True 19236487.032171033 35572776.69555581 8427879.795933258 1.0 1.8492345632580434 0.43811948521777916 24.197342022362655 -6.743691730058859 1.6727725121633226 1.5030907329573737 0.4365330020664626 0.6216369042754992 0.3567978001559015 0.3111429779763089 1.7107572763693526 0.16863254408358708 0.4122094237575977 1.8042980092184835e-07 6.743691730058859 -1.066557730890911 AGIIASAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGIIASAR 8 0 P13639 P13639 EEF2 Elongation factor 2 0 66359000.0 19513000.0 17057000.0 29789000.0 False True 26727483.418997407 16303365.340043887 22753451.723712925 1.0 0.6099850511348837 0.8513129113959224 24.671820668277633 -10.39685241365473 5.8817591130504585 1.0000763395876846 0.7306489812654028 0.6241967954328762 0.09852168639287193 9.865375393694748e-05 1.0116404390551836e-05 0.09542014627978589 0.031797737553321784 4.010029673610473e-11 10.39685241365473 -0.2694273583222818 AGIIASAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGIIASAR 8 0 P13639 P13639 EEF2 Elongation factor 2 0 29393000.0 9744600.0 12663000.0 6985400.0 False True 8103066.6589756645 12594781.905591289 8446014.843159635 1.0 1.5543228799235174 1.0423232584177362 22.95003657811115 -10.394985147290123 3.310232403374701 0.9970433230087337 1.2983230689418086 0.3116081625062568 0.20902297169725714 86246472.71717635 129505560.35793939 2481765.39850508 0.07649457853797283 4.027308073338788e-11 10.394985147290123 0.30127974593307494 AGIIASAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGIIASAR 8 0 P13639 P13639 EEF2 Elongation factor 2 0 35147800.0 12680000.0 13300000.0 9167800.0 False True 16414509.960167507 12559843.308360396 7499354.469571722 1.0 0.7651671197519091 0.4568734910618795 23.968468344455104 -6.967377405468254 0.314588257793859 1.0449937965820224 0.16718150017457264 0.9999540990719424 0.001506791159335839 0.0771632034757661 0.012061831628736759 0.0047800416469736765 0.02725164631873026 1.0780095159541725e-07 6.967377405468254 -0.8778122964074497 down AGIICQLNAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGIICQLNAR 10 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 41912800.0 6705800.0 19073000.0 16134000.0 False True 8791368.739059575 16227382.7459717 14464608.448256208 1.0 1.8458312041757865 1.6453192759383117 23.067656367153138 -10.126218332470474 4.363924857108184 0.9998904274822278 1.7455752400118483 0.948546225262464 0.08185865213329463 28564305.306441315 7.570761705165796 32906.935011433445 0.02802239390562878 7.477934684666714e-11 10.126218332470474 0.7456848125296205 AGIICQLNAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGIICQLNAR 10 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 12848800.0 5089700.0 1847700.0 5911400.0 False True 4928130.259460925 2585496.2456282075 4363027.001801323 1.0 0.5246404030544087 0.885331103703128 22.232608958919222 -9.919379632962265 6.091521392116478 1.0000000771295692 0.7049857533787004 0.47145301824509334 0.1472513619262974 1.5421026292408518e-07 2.7552855162682745e-08 0.1425755542286481 0.047525172703873325 1.2039830338887257e-10 9.919379632962265 -0.2950143237508688 AGIICQLNAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGIICQLNAR 10 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 53708000.0 6705800.0 8037200.0 38965000.0 False True 9185115.47743108 7682089.928533782 29762269.509365 1.0 0.8363629120841856 3.240271674590748 23.13086642867603 -6.89059669716854 1.0188201731672113 0.8726771609510672 3.449483810809826 0.9812783780153943 0.15005546871707656 0.11866137083231765 0.21901777554222338 0.1121312999104512 0.28015940879831674 1.2864807817431895e-07 6.89059669716854 2.5768066498587587 up AGIICQLNAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGIICQLNAR 10 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 13037300.0 5089700.0 1804800.0 6142800.0 False True 4232311.061940813 1795077.1841752473 7427231.078901858 1.0 0.4241364015791594 1.7548878072057275 22.0130142343535 -6.789116233592026 1.5000536729712801 0.6777807792027065 1.7686627736902147 0.7983948339063484 0.24466856524295819 0.23666870407604582 1.0521034239995017 0.12839585715332177 0.3007760861466015 1.625113755775045e-07 6.789116233592026 1.0908819944875083 AGIICQLNAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGIICQLNAR 10 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 35179100.0 5314400.0 21124000.0 8740700.0 False True 6879595.562485345 19948430.83051165 7149982.28715566 1.0 2.8996516800044296 1.039302706418491 22.713892323619685 -6.641270877214943 2.0394035094769025 2.2410229717359997 1.0469816182839302 0.15968673473311512 0.81253755645407 0.5301588846596967 4.215653940146291 0.32423975415330347 0.9000090741695147 2.2841736791170855e-07 6.641270877214943 -1.1940413534520695 AGILTTLNAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGILTTLNAR 10 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 43975000.0 10823000.0 11208000.0 21944000.0 False True 14189057.810081106 9535810.088441813 19673445.381711572 1.0 0.6720537907504167 1.3865223219919434 23.75827545813059 -6.781889860586118 1.5281930118345515 0.8147543096603518 1.392548364784637 0.774049373063897 0.13880344297946984 0.24769085855384246 1.1426101729982585 0.07152394977832502 0.16852411610299467 1.6523807977443196e-07 6.781889860586118 0.5777940551242853 AGILTTLNAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGILTTLNAR 10 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 18735600.0 6339600.0 2418400.0 9977600.0 False True 6138352.868121587 3384079.731789395 7364167.2384161 1.0 0.5513009441610949 1.1996976056330284 22.549420151990148 -6.720572276967925 1.7573993288077776 0.7271774325699205 1.1987079330320136 0.5151132678653123 0.18880170050809422 0.3542267905038143 2.1383956193424987 0.08529508982986503 0.21396700785839604 1.9029515146685353e-07 6.720572276967925 0.4715305004620931 AGILTTLNAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGILTTLNAR 10 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 35452500.0 8876700.0 18929000.0 7646800.0 False True 13466602.87369656 15550972.057047978 6135406.628288504 1.0 1.154780623064387 0.45560166033204963 23.682882622258074 -6.84864631475563 1.2416532909548952 1.0825089903364962 0.42837989368737334 0.9383056427148765 0.07447721871766293 0.15895284694332532 0.4722642004629956 0.046952834942772866 0.10855881776289272 1.416947258406342e-07 6.84864631475563 -0.6541290966491229 down AGILTTLNAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGILTTLNAR 10 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 27876800.0 10823000.0 8571300.0 8482500.0 False True 14824555.580577511 8192591.624501274 6479108.202571244 1.0 0.5526365751722669 0.43705244095545703 23.821485519653482 -13.999999999999957 0.1900128131762111 3.3982429078026377 0.3541419410683754 0.9994894001801217 0.005485574250514861 12.350935659187593 0.13823440629040812 10.966947492434343 0.0794806827260714 1.0000000000000981e-14 13.999999999999957 -3.0441009667342622 AGILTTLNAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGILTTLNAR 10 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 17816400.0 6339600.0 6319900.0 5156900.0 False True 5271658.291899316 6285853.444298076 6235183.947188407 1.0 1.1923863604659697 1.182774679605029 22.329825427424424 -10.336494948038988 5.398894531182099 0.9999509127314345 1.1875805200354412 0.9980346900441899 0.003923952279982226 2.3191998514501173e-06 2.8502137230932547e-07 0.003800343280665162 0.0012664501526375798 4.607921288558437e-11 10.336494948038988 0.18762960730400668 AGILTTLNAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGILTTLNAR 10 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 27626200.0 8876700.0 11816000.0 6933500.0 False True 11491063.1359163 11158429.212901223 5671674.143717744 1.0 0.971052815646326 0.4935726204471405 23.454008944350523 -6.919307861903505 0.8298453483124868 1.0108005165385445 0.4177876175397317 0.9939864273299185 0.018007252363092176 0.09858087002375385 0.10773775066513047 0.01545846829274487 0.046003380334203224 1.2041820193264265e-07 6.919307861903505 -0.5930128989988128 down AGIQTEEHPNPGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGIQTEEHPNPGKR 14 1 Q8TDB6 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 5580000.0 1094900.0 1530300.0 2954800.0 True False 1060142.9988179584 2141356.770409073 2180849.237900084 1.0 2.0198754062392053 2.0571274255753176 20.01582744710427 -10.961179229699965 0.57818650348683 6.81222740567359e-09 2.053175950142521 0.9998906859664204 0.0051209198122918785 2.7841111852312364 0.2839354192239656 3.737767449499404 0.006670773978357063 1.093504992775722e-11 10.961179229699965 2.053175943330294 AGIQTEEHPNPGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGIQTEEHPNPGKR 14 1 Q8TDB6 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 37066700.0 2886300.0 7718400.0 26462000.0 True False 4378728.116794572 6340991.215865551 21231774.101293363 1.0 1.448135405243531 4.848845037868208 22.06208044233248 -6.93109227359234 0.7377717411082544 0.9503246111305373 5.5668164748886255 0.9967485881209256 0.09799099714116542 0.0920746316079707 0.07493081485841117 0.08986161269560873 0.3058783207717779 1.1719463382358315e-07 6.93109227359234 4.616491863758088 up AGIQTEEHPNPGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGIQTEEHPNPGKR 14 1 Q8TDB6 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 3683150.0 563250.0 1366600.0 1753300.0 True False 771498.7462589185 1306219.0932581332 1339206.6503469674 1.0 1.6930929565240798 1.7358507150412446 19.55730428675128 -11.283904278230349 0.4710445356340847 1.1516572707557282e-13 1.7351383358962305 0.9997824615754087 0.004974266502492315 3.4865164563512754 0.23112316276825212 3.6429199232050213 0.009209460822825337 5.201106201929506e-12 11.283904278230349 1.7351383358961152 AGIQTEEHPNPGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGIQTEEHPNPGKR 14 1 Q8TDB6 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 4366300.0 1094900.0 1577100.0 1694300.0 True False 910457.86229424 1568603.8492701584 2048570.2964419187 1.0 1.7228736377952438 2.2500440506711397 19.796232722538548 -7.367746545642756 0.12217085336724809 1.1092059425759106e-14 3.779151098103092 0.999996504041902 0.0009580580164129959 0.12055769803104135 0.008366781183200396 0.09308568042480724 0.15501094982181482 4.287986944039598e-08 7.367746545642756 3.779151098103081 AGIQTEEHPNPGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGIQTEEHPNPGKR 14 1 Q8TDB6 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 41177800.0 2886300.0 4110500.0 34181000.0 True False 3736372.2474788176 3881747.0615801057 27960408.726677194 1.0 1.0389080114272293 7.483303823794315 21.83320676442493 -6.908224684896264 0.9077415569741923 0.7890933851593087 8.285260993514832 0.9902341421439825 0.3011245060160074 0.10560367669593913 0.145222706175105 0.24439076106842564 0.6666108007024933 1.2353081738861614e-07 6.908224684896264 7.496167608355524 up AGISFIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGISFIIK 8 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;P78347-5 A0A494C1K3 GTF2I General transcription factor II-I 0 50420000.0 13791000.0 17210000.0 19419000.0 False True 18080134.55223398 14642335.084054561 17409708.16020129 1.0 0.8098576391537615 0.9629191702033073 24.10790207853092 -9.976272330770724 5.3354135968964735 1.000000392113796 0.8863884047062299 0.42349878561785004 0.06248710838808326 2.914928667400109e-07 5.593183733688904e-08 0.06050309169624151 0.02016762751145068 1.0561550239144104e-10 9.976272330770724 -0.11361198740756617 AGISFIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGISFIIK 8 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;P78347-5 A0A494C1K3 GTF2I General transcription factor II-I 0 47789000.0 19536000.0 10910000.0 17343000.0 False True 18915840.373465728 15266419.8948984 12800348.021152398 1.0 0.8070706663560892 0.6766999386983693 24.173091536591393 -7.892414381990348 0.0712764385460539 1.6004449186655592 3.3328655182424254e-10 0.9999979754604513 0.0001888790929281034 0.12369128143413355 0.010384897428661227 0.10671867331420337 0.12099111127580323 1.2811076307274677e-08 7.892414381990348 -1.6004449183322726 AGISFIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGISFIIK 8 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;P78347-5 A0A494C1K3 GTF2I General transcription factor II-I 0 159471000.0 43057000.0 44802000.0 71612000.0 False True 65320616.88834291 36806733.060376324 57457856.81134532 1.0 0.5634780382324411 0.879628202372339 25.9610350799971 -10.350980716273602 5.543330614431445 1.0000703089261898 0.7215531203024025 0.5084247203644734 0.12906776403999354 0.00011217950346804732 1.313404420806935e-05 0.12500077942340793 0.04165644172159208 4.456760370531686e-11 10.350980716273602 -0.27851718862378727 AGISFIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGISFIIK 8 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;P78347-5 A0A494C1K3 GTF2I General transcription factor II-I 0 55598000.0 13791000.0 17220000.0 24587000.0 False True 18889905.387761645 16459163.461074958 18780056.985159937 1.0 0.8713205875418777 0.9941848092752822 24.17111214005381 -10.56227951430818 7.051235238395649 1.0000551067436994 0.9327526984092336 0.2854218983682957 0.05015910848183539 4.348875742999613e-05 2.6996829509370018e-06 0.04860610886075422 0.01618878265089663 2.7398102474655513e-11 10.56227951430818 -0.06730240833446577 AGISFIIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGISFIIK 8 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;P78347-5 A0A494C1K3 GTF2I General transcription factor II-I 0 41398400.0 19536000.0 8470400.0 13392000.0 False True 16245049.59154285 8424768.273957238 16192205.282388113 1.0 0.5186052665756811 0.996747051533641 23.95349681202567 -10.913438623400404 10.975436942173472 1.0271861186505613 0.7576761590597578 0.2551022504056757 0.19520056630842714 0.09816359510792501 0.0007741980961608637 0.14287788813961147 0.06300071187356625 1.220566304897645e-11 10.913438623400404 -0.2695099595908035 AGISFIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGISFIIK 8 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;P78347-5 A0A494C1K3 GTF2I General transcription factor II-I 0 154531000.0 43057000.0 64278000.0 47196000.0 False True 55738135.28035743 60700872.79509684 38606812.27185441 1.0 1.0890366620587022 0.6926462838712827 25.73216140208955 -6.8477139633553294 1.2459964413524853 1.047438056430901 0.6774790867610248 0.936920319375976 0.04264893618771127 0.15999213191534395 0.479124820309627 0.026798323477500753 0.06193191391127547 1.4199924544751592e-07 6.8477139633553294 -0.3699589696698762 AGIVTSLQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGIVTSLQAR 10 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 85141000.0 19575000.0 26866000.0 38700000.0 False True 25663014.564569637 22857697.52284778 34695695.23661304 1.0 0.8906863792379685 1.3519727056740218 24.613187314058724 -6.844205080921986 1.2627395349736945 0.9418413686262336 1.3684511174928113 0.9314457855499908 0.05153135389263087 0.16394118683117534 0.5059594422658731 0.03197568197703385 0.07376969799248631 1.4315117564957105e-07 6.844205080921986 0.42660974886657776 AGIVTSLQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGIVTSLQAR 10 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 32177000.0 9999300.0 4260700.0 17917000.0 False True 9681877.694840092 5962019.7292569745 13224000.201521516 1.0 0.6157916797931049 1.3658507800164816 23.20685543896581 -6.76745997680145 1.5840983756980662 0.7789140052182347 1.3696778910416183 0.72077369124861 0.16182342195780217 0.270559822983627 1.33949058127144 0.08053856522631297 0.1921715119739958 1.708205135559948e-07 6.76745997680145 0.5907638858233836 AGIVTSLQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGIVTSLQAR 10 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 81151000.0 17744000.0 41219000.0 22188000.0 False True 26918945.2601611 33863147.40448305 17802532.074654125 1.0 1.2579670963036977 0.6613383957877844 24.682118547497595 -6.789202477147024 1.4995948076694698 1.1443257370434226 0.6551376989820749 0.7987184294631791 0.10961010064905627 0.23653568749474208 1.0508495188367502 0.05753660030418795 0.13478150814106885 1.6247910676496654e-07 6.789202477147024 -0.4891880380613477 AGIVTSLQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGIVTSLQAR 10 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 50153000.0 19575000.0 11092000.0 19486000.0 False True 26812406.494484365 10601918.763661077 14883808.126767244 1.0 0.3954109365693087 0.5551089988818804 24.676397375581615 -10.531659479969532 9.570916266031215 1.0000172781124643 0.4752599677259298 0.9350461062063127 0.06519646092949885 2.4037568444268212e-05 1.1762241346217564e-06 0.06312827155914406 0.02104206728430097 2.93995389680042e-11 10.531659479969532 -0.5247573103865345 AGIVTSLQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGIVTSLQAR 10 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 29569000.0 9999300.0 11410000.0 8159700.0 False True 8314860.994098821 11348532.065292327 9865855.543809904 1.0 1.3648492829100267 1.1865328296903397 22.987260714400087 -10.473119530628999 5.749435126986435 0.9997422743771729 1.2756910563001833 0.7611735452545224 0.07279738718851736 0.00024071387488712193 2.2059072151857988e-05 0.07055083471575191 0.023495255685711633 3.3641896422760355e-11 10.473119530628999 0.2759487819230104 AGIVTSLQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGIVTSLQAR 10 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 67695000.0 17744000.0 31178000.0 18773000.0 False True 22969957.78653093 29442916.89233532 15356506.627246436 1.0 1.2818010884460567 0.668547446624005 24.453244869590044 -6.7817662061121124 1.5290818048799495 1.1591950860772278 0.6634250314177031 0.773574236528993 0.11926180885786974 0.24783172005836127 1.144648536232484 0.061425445767489255 0.1447201335282169 1.6528513387661115e-07 6.7817662061121124 -0.4957700546595246 AGK(ub)DLVSSLTSGLLTIGDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGKDLVSSLTSGLLTIGDR 19 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 1 8661500.0 1920500.0 1544400.0 5196600.0 True False 1859534.7787285496 2161086.9739396065 3835454.56534167 1.0 1.1621653967758765 2.062588239389719 20.826510300135055 -6.937497573999656 0.6824526423609417 0.9893225919534319 2.2885090667639614 0.9978173460039865 0.021836337451976662 0.08892710597513061 0.05995019004372199 0.02087270656002548 0.07839027657140393 1.1547884354030482e-07 6.937497573999656 1.2991864748105295 up AGK(ub)DLVSSLTSGLLTIGDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGKDLVSSLTSGLLTIGDR 19 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 1 24972000.0 2554800.0 6359200.0 16058000.0 True False 3875818.380898304 5224351.075343627 12884129.261528578 1.0 1.347934955128824 3.3242345216760145 21.88606953762197 -6.937005198378995 0.686856326310924 0.9762526023450381 3.8132937736441894 0.9977447879872423 0.04860742286363641 0.08915977603663418 0.06103214228889039 0.04630393352311575 0.17245981404006286 1.1560984039466734e-07 6.937005198378995 2.8370411712991515 up AGK(ub)DLVSSLTSGLLTIGDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGKDLVSSLTSGLLTIGDR 19 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 1 8070700.0 1920500.0 2734000.0 3416200.0 True False 1596980.8425756579 2719271.399343488 4130511.6252758554 1.0 1.702757683027535 2.586450328742857 20.60691557556933 -6.968022124649255 0.3017119037304996 0.8498229378175227 3.4671424991850563 0.9999625845578736 0.003970226744123853 0.07694984478265764 0.011315067479372724 0.014537681572436173 0.0791118881174373 1.0764103757038678e-07 6.968022124649255 2.6173195613675335 AGK(ub)DLVSSLTSGLLTIGDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGKDLVSSLTSGLLTIGDR 19 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 1 18535500.0 2554800.0 3816700.0 12164000.0 True False 3307238.9626368997 3604297.2898510545 9950276.813179867 1.0 1.0898206421036196 3.008635579585213 21.65719585971442 -6.916669638965092 0.8490527097868599 0.9523710022728503 3.295547561558079 0.9932048476128743 0.07636854711014117 0.10017131787104414 0.11605850920083483 0.0646642118947429 0.1879425139569495 1.2115193669979562e-07 6.916669638965092 2.343176559285229 up AGK(ub)FPSLLTHNENMVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGKFPSLLTHNENMVAK 17 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 32837700.0 7988800.0 7024900.0 17824000.0 True False 12119593.659511665 5771251.7092057755 14301078.587463275 1.0 0.4761918486166736 1.1799965402503032 23.530837993778615 -6.707376571053787 1.8041724601648625 0.677130976877316 1.1782504155833804 0.4528768875066431 0.2208205741567873 0.3803369042746755 2.4115376486864046 0.09745339465019595 0.24840384773399532 1.9616586107228355e-07 6.707376571053787 0.5011194387060643 AGK(ub)FPSLLTHNENMVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGKFPSLLTHNENMVAK 17 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 19564000.0 5869300.0 6727700.0 6967000.0 True False 8039338.821868563 6430447.968471205 5321538.089869012 1.0 0.7998727396560446 0.6619372821298929 22.938645424256347 -7.495064317460472 0.07863441116112546 1.5301131864872939 2.6726990223112e-07 0.9999990197330493 0.00013729227604278603 0.13302511039691142 0.006653112995591846 0.054488592102101864 0.07223634356772597 3.1984213998376885e-08 7.495064317460472 -1.5301129192173917 AGK(ub)FPSLLTHNENMVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGKFPSLLTHNENMVAK 17 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 15903300.0 5233700.0 7205500.0 3464100.0 True False 4352053.442222454 7166682.541320236 4188427.2938112803 1.0 1.6467358768601064 0.9624025415626296 22.053264841986856 -6.658962487080402 1.976579233015472 1.4166651396804648 0.9652686927891426 0.23108592967257058 0.2754370858539654 0.48698854943411723 3.6563734801176127 0.1126262551264191 0.30529866727627564 2.1929943507618204e-07 6.658962487080402 -0.4513964468913222 AGK(ub)FPSLLTHNENMVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGKFPSLLTHNENMVAK 17 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 33771700.0 7988800.0 4614900.0 21168000.0 True False 10341659.082790704 4358076.758176868 17315641.20202166 1.0 0.4214098263429544 1.6743581531164746 23.301964315871064 -6.781133149025201 1.531388562270188 0.6728723649407128 1.6846512257317636 0.7714072079484289 0.24479991381892474 0.24881433120045635 1.1525972315201576 0.12589419888308362 0.29678566642952875 1.6552624037985827e-07 6.781133149025201 1.011778860791051 AGK(ub)ITDEEATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGKITDEEATK 11 1 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0;F8VZQ1 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 1 3824920.0 386810.0 1759790.0 1678320.0 True False 507111.6558733691 1497236.1916076937 1504663.545982234 1.0 2.952478363032477 2.967124751630563 18.9519439093175 -10.664836171404847 0.8743717124663918 1.2664467631913369e-06 2.963641783201336 0.9999918604292032 0.00263581331815364 2.3100239987400406 0.4836878738860284 5.024124923334448 0.002026583640993603 2.1635345183796046e-11 10.664836171404847 2.963640516754573 AGK(ub)ITDEEATK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGKITDEEATK 11 1 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0;F8VZQ1 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 1 6665430.0 725100.0 1994330.0 3946000.0 True False 702082.097399673 2790676.3692935593 2912424.222537478 1.0 3.97485761227852 4.148267322759446 19.421280215203367 -10.191825294069226 0.6119909991206055 9.856641953265968e-14 4.127113163798729 0.9997111733206819 0.024557116470102766 1.4844372086400504 0.29546951301473007 2.650773454654752 0.029617257610069853 6.429463067017941e-11 10.191825294069226 4.12711316379863 AGK(ub)ITDEEATK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGKITDEEATK 11 1 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0;F8VZQ1 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 1 22133540.0 1449540.0 2129300.0 18554700.0 True False 2199058.155568861 1749309.778703165 14887355.412186103 1.0 0.7954813629067699 6.769877992760489 21.068454327060202 -6.8989721254824605 0.967732907414977 0.7445525177007167 7.384085916402673 0.9860482571228484 0.3271158915063056 0.11216619406875396 0.18171319881551626 0.2539990594568507 0.6575265151019981 1.261908525632444e-07 6.8989721254824605 6.639533398701956 up AGK(ub)ITDEEATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGKITDEEATK 11 1 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0;F8VZQ1 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 1 4368540.0 386810.0 1667490.0 2314240.0 True False 529824.1101472039 1593814.7781479612 1767664.175268903 1.0 3.008196017552208 3.3363226425799746 19.01515397084039 -10.109483878445658 0.41686176457555674 7.788024318203331e-23 3.361150620352248 0.9990453059573974 0.031909652274598445 1.447233753612145 0.18967101807488418 1.8148046538846445 0.07972969124866632 7.771701677868583e-11 10.109483878445658 3.361150620352248 AGK(ub)ITDEEATK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGKITDEEATK 11 1 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0;F8VZQ1 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 1 4926590.0 725100.0 2089640.0 2111850.0 True False 602952.7773765218 2078382.694558936 2553428.0709088496 1.0 3.447007415078316 4.234872392526236 19.201685490637644 -9.45921625487856 0.343937269508143 2.2135252606756534e-16 4.4414940142830845 0.9984398382348034 0.05440241409099596 0.8244241824331794 0.1383338378867412 1.224467539874291 0.2349595379214222 3.4736315053760944e-10 9.45921625487856 4.4414940142830845 AGK(ub)ITDEEATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGKITDEEATK 11 1 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0;F8VZQ1 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 1 12056840.0 1449540.0 879300.0 9728000.0 True False 1876458.1047051395 830366.18203318 7957603.817709137 1.0 0.4425178371694374 4.240757519582122 20.83958064915265 -6.869602820237383 1.136255627071115 0.6854805105870868 4.46147044830836 0.9642820475451778 0.3164943872859916 0.13723304834480454 0.33140380344808457 0.21622959083897722 0.5115598885651246 1.3501971276743026e-07 6.869602820237383 3.7759899377212727 up AGK(ub)IVVNLTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGKIVVNLTGR 11 1 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 1 15423980.0 1724700.0 4516280.0 9183000.0 True False 2261098.4020185596 3842468.6283215587 8232831.24955601 1.0 1.699381426695652 3.6410760549856125 21.108592348240258 -6.95317853380867 0.5227845656437652 0.9677013149506922 4.4598207208789535 0.9994276997604415 0.02672818152531336 0.08223394163449932 0.030870171851584874 0.030147142025021 0.16043091855883107 1.1138365531889022e-07 6.95317853380867 3.4921194059282614 AGK(ub)IVVNLTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGKIVVNLTGR 11 1 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 1 11849460.0 2438500.0 3700860.0 5710100.0 True False 2361091.152267416 5178632.697729941 4214453.51067188 1.0 2.19332180070929 1.7849601048331543 21.17102230863986 -10.050409417960664 4.651981282364774 0.9999629001759426 1.9891409528068873 0.8866579627363658 0.16671296434976027 116389721.55292939 114281278.07538994 55687.08821407453 0.061010701523090696 8.9041113423497e-11 10.050409417960664 0.9891780526309447 AGK(ub)IVVNLTGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGKIVVNLTGR 11 1 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 1 36003000.0 5714500.0 5696900.0 24591600.0 True False 8669314.2859102 4680243.684917141 19731059.481118802 1.0 0.5398631922392876 2.2759654143796237 23.047486454877394 -6.836214594729249 1.2998294620619135 0.7549793179358595 2.328933442268338 0.9177635726238611 0.2105982164579965 0.17325669180119396 0.5702477067256918 0.12711901173871432 0.2926319836937442 1.458093605204902e-07 6.836214594729249 1.5739541243324786 up AGK(ub)IVVNLTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGKIVVNLTGR 11 1 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 1 17690100.0 1724700.0 1996300.0 13969100.0 True False 2362368.1982649933 1908096.8651186984 10669886.282645194 1.0 0.8077051098639375 4.516605959427297 21.17180240976315 -6.894673236306143 0.9942957781629507 0.8224633535593856 4.8664549855592965 0.9837257507526593 0.2174920819732684 0.115434453068001 0.20033947700704255 0.1655551616238805 0.42032975216171026 1.2744616268365739e-07 6.894673236306143 4.043991631999911 up AGK(ub)IVVNLTGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGKIVVNLTGR 11 1 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 1 12973100.0 2438500.0 5627300.0 4907300.0 True False 2027720.7938665687 5596984.617968398 5933393.741208423 1.0 2.760234365055636 2.926139416805163 20.951427584074136 -10.414752729671674 0.48414326758170356 8.398468156827459e-23 2.9229234023727906 0.9995114370722975 0.019263660612319655 1.799450069899573 0.22836832132549553 2.33175021011731 0.03470028148143342 3.8481081594494005e-11 10.414752729671674 2.9229234023727906 AGK(ub)IVVNLTGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGKIVVNLTGR 11 1 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 1 76232100.0 5714500.0 23620900.0 46896700.0 True False 7397532.899635425 22306376.15056014 38361981.800777145 1.0 3.0153804590256668 5.185780492124307 22.818612776969843 -6.970180429778325 0.2538405806032547 0.3429556813398278 7.922086141517467 0.9999837557702616 0.006888893785712797 0.07624421614444604 0.008820466743171563 0.04717525168818417 0.2067321260771269 1.0710742297334224e-07 6.970180429778325 7.579130460177639 AGK(ub)KPLAHYSSLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGKKPLAHYSSLVR 14 2 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 5621300.0 1341200.0 1323500.0 2956600.0 True False 1298624.3401357627 1851980.451961321 2182177.7639012416 1.0 1.4261094565405332 1.6803764541122872 20.308552724510413 -9.743529604559667 0.10503945009661597 2.48695226060967e-16 2.3562193149891386 0.9999266800049776 0.002403546799756929 1.2708912519445985 0.045725687406098316 0.689457111187474 0.34158501926104673 1.8049716934003496e-10 9.743529604559667 2.356219314989138 AGK(ub)KPLAHYSSLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGKKPLAHYSSLVR 14 2 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 4848350.0 1341200.0 2713100.0 794050.0 True False 1115267.2252343004 2698483.991791812 960082.1837276191 1.0 2.419585127882604 0.8608539388628772 20.08895799994469 -6.667009836208448 1.9478499524500417 1.9084275512020354 0.867215351030286 0.2659176625165752 0.6034263105464881 0.46802309728345853 3.420474607105086 0.2496487789552775 0.6696404784818877 2.1527329775538966e-07 6.667009836208448 -1.0412122001717494 AGK(ub)PVICATQMLESMIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGKPVICATQMLESMIK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 9464800.0 1765200.0 4638600.0 3061000.0 True False 2314194.2942211158 3946538.961121182 2744277.0831853403 1.0 1.7053619788866783 1.1858455835096493 21.142078564081583 -10.632833124731977 4.910137595214949 0.9929836864407183 1.4456037811981701 0.49518656875901035 0.21209168028064226 0.01644293101056365 0.001229557299399266 0.20728148868797386 0.06845229546633652 2.3289859858230098e-11 10.632833124731977 0.4526200947574518 AGK(ub)PVICATQMLESMIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGKPVICATQMLESMIK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 24227700.0 12638000.0 8092500.0 3497200.0 True False 12236813.607691448 11323877.45183 2581178.406248871 1.0 0.925394290937992 0.2109355007766459 23.54472460207507 -6.9269120926415715 0.7717191081317551 1.0121990466795974 0.07516558248747178 0.9958957294186033 0.02278714795415801 0.09427328899575219 0.08577015163907226 0.020390805836729135 0.06577801505969628 1.1832810443405158e-07 6.9269120926415715 -0.9370334641921256 down AGK(ub)PVICATQMLESMIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGKPVICATQMLESMIK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 62632500.0 14544000.0 15855500.0 32233000.0 True False 22064311.308824528 13025962.145413065 25862133.421774246 1.0 0.5903634137088787 1.172125114615782 24.39521138152999 -6.717462153634063 1.7682293724347409 0.7501155314280221 1.171106048721782 0.5006407129561392 0.1724318188980546 0.36025783396733285 2.1998950473195693 0.07746806301936926 0.1950727154249762 1.9166280790115314e-07 6.717462153634063 0.4209905172937598 AGK(ub)PVICATQMLESMIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGKPVICATQMLESMIK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 24794200.0 1765200.0 11745000.0 11284000.0 True False 2417842.142736338 11226067.064478844 8618951.601274848 1.0 4.643010751634098 3.5647288335873513 21.205288625604474 -9.338963418332964 8.472611056646034 0.9999999999999993 4.103869792532537 0.9169982188725133 0.44020674968641166 0.0 0.0 0.4262283526033193 0.14207611753443974 4.5818047873106485e-10 9.338963418332964 3.103869792532538 AGK(ub)PVICATQMLESMIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGKPVICATQMLESMIK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 23326600.0 12638000.0 2945000.0 7743600.0 True False 10509056.958329175 2929134.700463266 9362750.957638934 1.0 0.27872479063325645 0.8909220869926191 23.325129877509347 -10.494866744875022 8.708793736757508 1.0000165627138584 0.5848234388131822 0.3801246010927677 0.24992849966530872 8.03756098394911e-05 4.661861555906536e-06 0.24200185586718123 0.08066407641219553 3.1998767813184644e-11 10.494866744875022 -0.4151931239006762 AGK(ub)PVICATQMLESMIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGKPVICATQMLESMIK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 43726000.0 14544000.0 10656000.0 18526000.0 True False 18827494.705100615 10062984.232623182 15154458.092812434 1.0 0.5344834451020712 0.8049110266756252 24.16633770362244 -10.22858470856607 5.634903425842829 1.000014861462146 0.6696972358888382 0.6654534795184206 0.11040159787171758 2.0613179518556142e-05 2.8219627036634e-06 0.10690069407174951 0.03563196249598212 5.907657262605377e-11 10.22858470856607 -0.3303176255733078 AGK(ub)YLEHGEYEGNLYGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGKYLEHGEYEGNLYGTK 18 1 B8ZZG1;Q9NZW5 B8ZZG1 MPP6 MAGUK p55 subfamily member 6 1 6709800.0 3772300.0 1701800.0 1235700.0 True False 3652550.4013526235 2381337.6147697633 912033.0997946176 1.0 0.6519657097374753 0.24969760840449204 21.80047275016398 -7.377820979700083 0.35194052104124113 1.052086645353257 3.122113790188228e-10 0.999600495423894 0.006127724691203231 0.11208428449421473 0.03134755939593511 0.014988558028206618 0.05676209556460188 4.1896623137797136e-08 7.377820979700083 -1.0520866450410455 down AGK(ub)YLEHGEYEGNLYGTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGKYLEHGEYEGNLYGTK 18 1 B8ZZG1;Q9NZW5 B8ZZG1 MPP6 MAGUK p55 subfamily member 6 1 16780500.0 7669900.0 5034300.0 4076300.0 True False 11635799.044798784 4135889.831834571 3270617.518294243 1.0 0.35544527848161134 0.28108233097719343 23.47206695002024 -13.999999999999998 0.3047874164729169 7.044179933055408 0.26367711539203764 0.9996604833586318 0.005947980990395185 16.90711891234906 0.17547960733534818 64.61942997436559 0.02633301382074433 1.0000000000000041e-14 13.999999999999998 -6.78050281766337 AGK(ub)YLEHGEYEGNLYGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGKYLEHGEYEGNLYGTK 18 1 B8ZZG1;Q9NZW5 B8ZZG1 MPP6 MAGUK p55 subfamily member 6 1 7420600.0 3429500.0 2235400.0 1755700.0 True False 4697478.828752708 2136632.6365207294 1341039.8197765201 1.0 0.45484667720962485 0.285480758650401 22.16345522884661 -13.999999999999998 0.16368693273546206 3.706779916951305 0.12557778400677475 0.9995271600991709 0.006628976347725494 12.036292704853361 0.12796891471090244 10.341919566309663 0.1464415933601522 1.0000000000000041e-14 13.999999999999998 -3.5812021329445303 AGK(ub)YLEHGEYEGNLYGTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGKYLEHGEYEGNLYGTK 18 1 B8ZZG1;Q9NZW5 B8ZZG1 MPP6 MAGUK p55 subfamily member 6 1 17440200.0 7669900.0 5622400.0 4147900.0 True False 9928836.746331919 5309508.497513183 3393024.761048074 1.0 0.5347563499293825 0.34173436906408833 23.243193272112688 -13.999999999999865 0.1207298010933016 3.21628292708179 0.03666743262010273 0.9996893684964138 0.004869526776134088 11.96101287004524 0.10702822656359456 6.354262974295654 0.27072737925851204 1.0000000000003108e-14 13.999999999999865 -3.1796154944616872 AGKPHLVLGLLWQIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGKPHLVLGLLWQIIK 16 1 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 16538400.0 0.0 11157000.0 5381400.0 False True 0.0 9165946.179961115 4317763.931248593 0.0 AGKPHLVLGLLWQIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGKPHLVLGLLWQIIK 16 1 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 9007300.0 0.0 6846000.0 2161300.0 False True 0.0 6465014.08188234 1767965.5768107278 0.0 AGKPVICATQMLESMIK ddPTM_RPMI8226_Bortezomib_1h_R1 3 AGKPVICATQMLESMIK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 110933200.0 15667600.0 71229400.0 24036200.0 False True 20540375.32525423 60602251.17002649 21549164.595511075 1.0 2.950396485477872 1.0491125042401999 24.291959207841153 -6.640272767666479 2.0436314134433955 2.275218423859895 1.0570583092532544 0.1555386996875897 0.8344681477534368 0.5327277037674063 4.252668672599008 0.33249302606734843 0.9239423057681265 2.289429277521889e-07 6.640272767666479 -1.2181601146066405 AGKPVICATQMLESMIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGKPVICATQMLESMIK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 62862800.0 43452000.0 8340800.0 11070000.0 False True 42072640.0444223 11671324.93669738 8170434.907118567 1.0 0.27740890337222096 0.19419829367712205 25.326379013801326 -13.999999999999998 0.3050567566167568 7.786541781809868 0.17477734362646608 0.9996610807482441 0.006661454528296736 16.925402822398727 0.1755654477182861 72.70981932637804 0.029432693961155186 1.0000000000000041e-14 13.999999999999998 -7.611764438183402 AGKPVICATQMLESMIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGKPVICATQMLESMIK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 132002100.0 4961300.0 118030000.0 9010800.0 False True 7526654.819614355 96966624.3274009 7229811.430426061 1.0 12.88309702667741 0.9605610465336175 22.843577378782374 -6.64692591532609 2.0191756871049495 8.729647931301994 1.0103214625323282 0.18172198320729982 5.07569726970587 0.5161701334825972 4.030052871334737 2.0409878863737707 5.622443369733524 2.2546237872024485e-07 6.64692591532609 -7.719326468769665 AGKPVICATQMLESMIK ddPTM_RPMI8226_Carfilzomib_1h_R1 3 AGKPVICATQMLESMIK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 203390400.0 15667600.0 84171300.0 103551500.0 False True 21460335.120969787 80452333.64873293 79094768.41008624 1.0 3.7488852431814825 3.685625968291588 24.355169269364044 -10.16219346717494 4.586843959056509 0.9996108670491708 3.71725560575342 0.999593676236839 0.025825490970701116 9043735.106786154 28.049231545927256 37266.633838256814 0.008840752455923537 6.88345587535865e-11 10.16219346717494 2.7176447387042493 AGKPVICATQMLESMIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGKPVICATQMLESMIK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 59207700.0 43452000.0 2779700.0 12976000.0 False True 36132263.24998571 2764725.2043727473 15689221.605754761 1.0 0.07651680121017165 0.43421640922980287 25.106784289235602 -10.592577568168293 6.410571874749267 1.001820252874022 0.2553666073138484 0.85246654350441 0.14603025347360835 0.0038055633569084243 0.0002418617083666975 0.14163620334242127 0.04713106164547774 2.5551854855047606e-11 10.592577568168293 -0.7464536455601737 AGKPVICATQMLESMIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGKPVICATQMLESMIK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 24488800.0 4961300.0 12327000.0 7200500.0 False True 6422500.651843765 11640991.613696117 5890082.883369105 1.0 1.8125325702153465 0.9171011733067223 22.614703700874824 -6.6677609527723805 1.9449607915078175 1.5196120550434455 0.9207231350756566 0.269359565508259 0.3453214653258535 0.46625039355764336 3.3980845476488355 0.1430335414203822 0.38331774686776676 2.1490130225421098e-07 6.6677609527723805 -0.5988889199677889 AGLGSGLSLSGLVHPELSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGLGSGLSLSGLVHPELSR 19 0 P49748-2;P49748;P49748-3;G3V1M7 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 21183700.0 4247800.0 8445800.0 8490100.0 False True 5568906.935753717 7185719.561470556 7611625.894789881 1.0 1.2903285410170018 1.3668078821575234 22.408962752702777 -12.872096225772145 0.20282508772734073 2.1342962089709156e-09 1.4175565215314738 0.9994394867684986 0.0037407689393586943 7.821692787366437 0.1351999986495002 3.184891036305985 0.047621130475956154 1.3424674803100192e-13 12.872096225772145 1.4175565193971775 AGLGSGLSLSGLVHPELSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGLGSGLSLSGLVHPELSR 19 0 P49748-2;P49748;P49748-3;G3V1M7 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 49769000.0 22916000.0 11357000.0 15496000.0 False True 22188544.123584207 15891909.325972607 11437132.729964707 1.0 0.716221363486444 0.5154521480212024 24.40331167403619 -7.737735257114641 0.128579714608845 1.3805271269421522 2.5403655609200098e-11 0.9999846226433287 0.000779478155243716 0.13409242521853518 0.016049005444742845 0.06760652076967605 0.09314311520778479 1.8292149530101333e-08 7.737735257114641 -1.3805271269167485 AGLGSGLSLSGLVHPELSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGLGSGLSLSGLVHPELSR 19 0 P49748-2;P49748;P49748-3;G3V1M7 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 57801400.0 7978400.0 34663000.0 15160000.0 False True 12103816.099169822 28477116.82674485 12163619.35513597 1.0 2.3527387225172762 1.0049408595996636 23.528958637279416 -6.64533711596251 2.025161545312666 1.881015453755293 1.010592337605357 0.1753466630404813 0.5780317629654689 0.5200752323082923 4.082870558284493 0.23191183427738157 0.6401525766358941 2.2628870862943706e-07 6.64533711596251 -0.8704231161499361 AGLGSGLSLSGLVHPELSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGLGSGLSLSGLVHPELSR 19 0 P49748-2;P49748;P49748-3;G3V1M7 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 36727800.0 4247800.0 16145000.0 16335000.0 False True 5818326.452478713 15431660.515624573 12477009.429885212 1.0 2.6522507187698974 2.1444326872669337 22.47217281422567 -9.976036149281656 6.590775204864913 0.9999997509895386 2.3983417030184304 0.9099906153310362 0.2073158432278631 7.594786548032603e-07 1.1799816354293852e-07 0.20073273794745944 0.06691090068553047 1.0567295467700175e-10 9.976036149281656 1.3983419520288918 AGLGSGLSLSGLVHPELSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGLGSGLSLSGLVHPELSR 19 0 P49748-2;P49748;P49748-3;G3V1M7 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 37453900.0 22916000.0 6537000.0 8000900.0 False True 19055669.350931425 6501783.883507094 9673851.198018141 1.0 0.3411994490337487 0.5076626288934475 24.183716949470465 -10.533135926001211 9.555913295665134 1.0000198968695946 0.4244310389651968 0.9409692450476441 0.06795830860290059 2.880823625676733e-05 1.4074517999735105e-06 0.06580261152307404 0.02193344978795484 2.92997607434794e-11 10.533135926001211 -0.5755888579043977 AGLGSGLSLSGLVHPELSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGLGSGLSLSGLVHPELSR 19 0 P49748-2;P49748;P49748-3;G3V1M7 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 25780400.0 7978400.0 17802000.0 0.0 False True 10328196.077776056 16811303.050784312 0.0 1.0 1.6277095171497022 0.0 23.300084959371866 -6.817135775611027 1.4842590659856991 1.344429924217259 3.0516397785729028e-21 0.8378289113418311 0.26992424989061675 0.209014360676497 0.9216994782299129 0.14509405137720102 0.3197839323458734 1.5235763561932854e-07 6.817135775611027 -1.344429924217259 AGLGTAMLYELIEK(ub)GK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGLGTAMLYELIEKGK 16 1 Q96BH1 Q96BH1 RNF25 E3 ubiquitin-protein ligase RNF25 1 16362000.0 3137200.0 5747800.0 7477000.0 True False 3037611.3032164564 8042926.514381021 5518549.394808083 1.0 2.647780019077672 1.8167398142628117 21.534505841797813 -10.20477683401169 5.622159243883109 0.9999686386353617 2.2322599166462984 0.745648266212922 0.3392707429748155 0.00017721219328454825 2.506540223464599e-05 0.32850849884988004 0.10949916144184699 6.240554294032979e-11 10.20477683401169 1.2322912780109367 AGLITNFNEPINQIATQIAVLIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGLITNFNEPINQIATQIAVLIAK 24 0 F8WDV0;Q9UI26;Q9UI26-2;D6RJB1;D6RCN7 F8WDV0 IPO11 Importin-11 0 307882000.0 159200000.0 96153000.0 52529000.0 False True 241518039.07899278 78993745.90318203 42146620.12572141 1.0 0.32707182537758894 0.17450713117100378 27.84755570765426 -13.999999999999998 0.20852046262694054 4.868312013171344 0.08334712398385863 0.9994892344648985 0.008105106113928647 12.7124594595259 0.14474599814005756 20.13288933512843 0.09131773022627493 1.0000000000000041e-14 13.999999999999998 -4.784964889187486 AGLLFIFNFHPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGLLFIFNFHPSK 13 0 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 0 7477500.0 3377200.0 1340400.0 2759900.0 False True 3269992.634585816 1875628.7100936559 2036999.3947747527 1.0 0.5735880534578718 0.6229369978482423 21.640855955488362 -10.85826991202381 11.141295645665178 1.0105897457415576 0.598262525653057 0.9888096151023321 0.02014662218356501 0.005065375907206444 6.443726809514033e-05 0.018645494522526406 0.006502294349940014 1.3858942342662095e-11 10.85826991202381 -0.41232722008850053 AGLLFIFNFHPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGLLFIFNFHPSK 13 0 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 0 121256500.0 26108500.0 39524000.0 55624000.0 False True 39608503.287021846 32470633.397578545 44629892.01913467 1.0 0.8197894568820504 1.126775523319462 25.239306850402613 -6.747589684358908 1.65859658347395 0.8937305857008303 1.1272819888843366 0.6386289594093459 0.0757184572556994 0.3042554727230099 1.6459812214587421 0.03607380705873276 0.087806012500561 1.7881762220943568e-07 6.747589684358908 0.2335514031835063 AGLLFIFNFHPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGLLFIFNFHPSK 13 0 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 0 1583360.0 505490.0 483940.0 593930.0 False True 692383.3133536095 462557.93062442617 453655.9663723127 1.0 0.6680662599795953 0.6552092715449721 19.401211430175323 AGLLFIFNFHPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGLLFIFNFHPSK 13 0 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 0 8159600.0 3377200.0 2506300.0 2276100.0 False True 2808291.435327526 2492798.064438398 2752021.9865026562 1.0 0.8876564707920591 0.9799631020780052 21.42126123092264 -10.321541712220737 6.883430853289619 1.0000014147276466 0.9338097864350323 0.40673370525870545 0.03768402442096561 8.181565983869467e-07 8.064962949881428e-08 0.03648817942051063 0.012162466583372786 4.769340043456834e-11 10.321541712220737 -0.06619162829261427 AGLLFIFNFHPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGLLFIFNFHPSK 13 0 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 0 83561500.0 26108500.0 23637000.0 33816000.0 False True 33797967.92547578 22321580.17140712 27661834.98146091 1.0 0.6604414863232607 0.8184466901221698 25.010433172495063 -10.08050846906903 4.7111435317117065 1.0000110325426095 0.739444088218443 0.7838188242199751 0.06450535435523812 8.222117646850744e-06 1.6048412222316753e-06 0.06245994815111726 0.020819013593734552 8.307905175040168e-11 10.08050846906903 -0.2605669443241665 AGLLHNILPSQSTDLHHSVGTELLSLVYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGLLHNILPSQSTDLHHSVGTELLSLVYK 29 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 117477000.0 31494000.0 23415000.0 62568000.0 False True 47778700.519810215 19236410.307769973 50201407.37547146 1.0 0.40261476554378217 1.0507068385976033 25.509864280267816 -12.037740625967448 18.65575759051523 0.9162011247879343 0.75399472186363 0.0 0.3011226498682588 0.0 0.0 0.0 0.08765602870692663 9.167678486341652e-13 12.037740625967448 -0.16220640292430422 AGLLHNILPSQSTDLHHSVGTELLSLVYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGLLHNILPSQSTDLHHSVGTELLSLVYK 29 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 70194400.0 24778000.0 21670300.0 23746100.0 False True 20604004.851517662 21553557.79268221 28711299.7204388 1.0 1.046085843407992 1.3934815065006145 24.2964214490893 -6.931219420141227 0.7367062097452461 0.9949491891373142 1.467068380068165 0.9967727094133069 0.009977806734015266 0.09200921138349431 0.07461211891642623 0.00915716926084659 0.031225098188172963 1.171603282709298e-07 6.931219420141227 0.47211919093085075 AGLLHNILPSQSTDLHHSVGTELLSLVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGLLHNILPSQSTDLHHSVGTELLSLVYK 29 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 63279400.0 31494000.0 14465700.0 17319700.0 False True 40769603.83955162 13660671.078627713 14167692.315129206 1.0 0.3350699980404311 0.3475062541908923 25.280990602360266 -9.986299323350107 5.407201443740744 1.00000199283696 0.3412881261150129 0.9997327399322781 0.005077080319172865 1.3310641316660804e-07 2.494720081669436e-08 0.004915878099887429 0.0016386206260882894 1.0320498537790083e-10 9.986299323350107 -0.658713866721947 AGLLPSGPRPGYAAIQALLSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGLLPSGPRPGYAAIQALLSSR 22 1 P22570-5;P22570;P22570-2;P22570-7;P22570-3;J3QQX3;A0A0A0MTR6;A0A0C4DFN8;A0A0C4DGN7;A0A0A0MSZ4;A0A0A0MT64;P22570-4;P22570-6;A0A0A0MTN9 P22570-5 FDXR NADPH:adrenodoxin oxidoreductase, mitochondrial 0 12771600.0 5004500.0 2775700.0 4991400.0 False True 4845634.886824802 3884051.485084275 3684002.6012097145 1.0 0.8015567775535347 0.7602724281242185 22.208254272749087 -13.999999999999998 0.22068098950102305 2.2010792434296294 0.7383329217364097 0.9994985811413757 0.002343222920554071 13.018268937732397 0.14881418455742654 6.8164047544737505 0.022745651504346463 1.0000000000000041e-14 13.999999999999998 -1.4627463216932197 AGLLPSGPRPGYAAIQALLSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGLLPSGPRPGYAAIQALLSSR 22 1 P22570-5;P22570;P22570-2;P22570-7;P22570-3;J3QQX3;A0A0A0MTR6;A0A0C4DFN8;A0A0C4DGN7;A0A0A0MSZ4;A0A0A0MT64;P22570-4;P22570-6;A0A0A0MTN9 P22570-5 FDXR NADPH:adrenodoxin oxidoreductase, mitochondrial 0 10769900.0 5004500.0 1644300.0 4121100.0 False True 4161463.4869408407 1635441.8295320047 4982802.956186498 1.0 0.3929967990021329 1.1973679384243348 21.988659548183364 -6.7048744379977085 1.8136869906093966 0.6248786577539582 1.1951880953511134 0.44060004745777726 0.2560040044300292 0.3854919861447012 2.4685657571228683 0.11247123796413316 0.2874971805002786 1.9729930798872496e-07 6.7048744379977085 0.5703094375971551 AGLLQVYIHTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGLLQVYIHTQK 12 0 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 0 55860300.0 19921900.0 3884600.0 32053800.0 False True 26117803.823954012 3305032.822052203 28737180.257760912 1.0 0.12654328994618544 1.100290838060608 24.638530253840965 -12.282247195316156 15.77916456859687 0.9707606496365174 0.6520753588284302 0.0 0.44651712441269586 0.0 0.0 0.0 0.13060273728984714 5.220989318321451e-13 12.282247195316156 -0.3186852908080873 AGLLQVYIHTQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGLLQVYIHTQK 12 0 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 0 117949300.0 47822600.0 31461900.0 38664800.0 False True 46304497.73976772 44024800.741641015 28537328.960863426 1.0 0.9507672664772512 0.616297127791858 25.464648999202517 -6.933266677516389 0.719473492888751 1.0045215360371675 0.5415479683188755 0.9971421928077596 0.009112745888951865 0.09097687765345638 0.06962863068338554 0.008469763272693972 0.02973892525110786 1.1660933602601684e-07 6.933266677516389 -0.462973567718292 AGLLQVYIHTQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGLLQVYIHTQK 12 0 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 0 342186000.0 102438000.0 40280000.0 199468000.0 False True 155405935.22094104 33091719.290923525 160043062.37006995 1.0 0.21293729382907375 1.0298388034056505 27.211466362910826 -11.779627006964711 13.647975448267262 0.9357767697953537 0.6592492446927918 0.0 0.3884336304307717 0.0 0.0 0.0 0.11214814460712128 1.6610128529181876e-12 11.779627006964711 -0.27652752510256196 AGLLQVYIHTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGLLQVYIHTQK 12 0 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 0 66589600.0 19921900.0 36311700.0 10356000.0 False True 27287564.79910437 34707329.02726574 7910126.08851491 1.0 1.2719100910171692 0.28988024936452134 24.701740315363857 -6.832851826346087 1.3151651547177103 1.1450241131766512 0.26188911037319285 0.9114572823803423 0.12319132042330622 0.17731256176113108 0.5987979903091497 0.07352450847453508 0.16919740800758676 1.4694275350105016e-07 6.832851826346087 -0.8831350028034584 down AGLLQVYIHTQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGLLQVYIHTQK 12 0 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 0 76604200.0 47822600.0 13642600.0 15139000.0 False True 39766610.80039502 13569104.605955929 18304494.905172758 1.0 0.34121853315749856 0.46029808768593705 25.245054274636793 -10.017095955347205 5.996408616513756 1.000000765081553 0.4007583104247845 0.971235541734629 0.048614024565629785 4.972871865051798e-07 8.1353144957352e-08 0.04707038684817127 0.015690108961204787 9.613998380899764e-11 10.017095955347205 -0.5992424546567685 AGLLQVYIHTQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGLLQVYIHTQK 12 0 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 0 377649000.0 102438000.0 148694000.0 126517000.0 False True 132608010.35486086 140419048.18746904 103492204.17404449 1.0 1.058903212646851 0.7804370482378699 26.982592685003276 -6.851429353972987 1.2281082742717297 1.0314764912548133 0.7689902618071042 0.942367962975296 0.02876584090901377 0.1558917132795844 0.45172823867323564 0.01832101779981706 0.042438152103315474 1.4078962300880413e-07 6.851429353972987 -0.26248622944770916 AGLNGLQLAVLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGLNGLQLAVLAR 13 0 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 0 12312200.0 3740200.0 4737500.0 3834500.0 False True 4903438.420148325 4030683.466630367 3437742.723121264 1.0 0.8220116418854593 0.7010881811007377 22.22536232917264 -7.649067363259362 0.06590021156194945 1.600982593050645 0.0006761873452401972 0.9999991997596608 0.00010967279312902078 0.13914945665277256 0.007097957069729024 0.07668282444033027 0.09268744762566909 2.2435339030638784e-08 7.649067363259362 -1.6003064057054048 AGLNGLQLAVLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGLNGLQLAVLAR 13 0 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 0 11228900.0 3079200.0 4541300.0 3608400.0 False True 2981452.4814688675 6354664.772566642 2663251.7903203834 1.0 2.1313989782040395 0.8932732642474595 21.50758391252747 -6.66638485727753 1.9513122403371939 1.7244369191088174 0.8984644474353699 0.2627543736081488 0.48100399296779955 0.469408023037838 3.4425655805613045 0.19875026278917188 0.5333087891586594 2.1558331350395845e-07 6.66638485727753 -0.8259724716734475 AGLNGLQLAVLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGLNGLQLAVLAR 13 0 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 0 28814900.0 6707900.0 12177000.0 9930000.0 False True 10176374.713178232 10003919.210664755 7967331.147526382 1.0 0.9830533458747199 0.7829243096963424 23.278720363658213 -6.923628025913063 0.7973737559114974 1.0038656949316078 0.7477976147398965 0.9951303380503724 0.006879144206875853 0.09608441089668826 0.09490094299363604 0.006043901363057623 0.018782510463636368 1.1922627462446726e-07 6.923628025913063 -0.25606808019171134 AGLNGLQLAVLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGLNGLQLAVLAR 13 0 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 0 13555100.0 3740200.0 3573200.0 6241700.0 False True 5123053.015104498 3415324.209007724 4767539.011846617 1.0 0.6666579867391944 0.9306050508925625 22.28857239069553 -9.876214708527378 6.05905403902536 1.0000000312547253 0.7986315188157795 0.43695185345046406 0.10775593771392032 4.5494029960704454e-08 8.467519505495987e-09 0.10433425360208386 0.03477807935169648 1.3297968242958645e-10 9.876214708527378 -0.2013685124389457 AGLNGLQLAVLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGLNGLQLAVLAR 13 0 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 0 7122400.0 3079200.0 1671700.0 2371500.0 False True 2560491.23168913 1662694.2202935289 2867369.6854228913 1.0 0.6493653247922534 1.119851398019167 21.287989187961745 -6.7071655662327085 1.8051776348195052 0.7838173867368745 1.1186623901393054 0.45167967014238797 0.1478227004763425 0.3808072613883598 2.417132980880894 0.06520803954233993 0.16623906819827533 1.962611926987363e-07 6.7071655662327085 0.33484500340243084 AGLNGLQLAVLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGLNGLQLAVLAR 13 0 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 0 24331000.0 6707900.0 8751400.0 8871700.0 False True 8683508.782476934 8264376.89690113 7257141.631329153 1.0 0.9517324279763959 0.8357383879168582 23.049846685750662 -6.956303307780505 0.484739646930284 1.0026637239156264 0.7799321282341052 0.9996075420500791 0.0013655953570436098 0.08104918234651594 0.02621969749898731 0.001651528478401453 0.009567299342276613 1.1058511966245264e-07 6.956303307780505 -0.22273159568152123 AGLQFPVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGLQFPVGR 9 0 Q71UI9;P0C0S5;A0A494C189;C9J0D1;Q71UI9-2;Q71UI9-5;Q8IUE6;A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;Q9BTM1-2;A0A3B3IS11;Q93077;Q7L7L0;P04908;P16104;Q96QV6;Q16777 Q71UI9;Q8IUE6;A0A0U1RR32;Q93077;P16104;Q16777 H2AFV;H2AFZ;HIST2H2AB;HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;H2AFX;HIST1H2AA;HIST2H2AC Histone H2A.V;Histone H2A.Z;Histone H2A;Histone H2A type 2-B;Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2AX;Histone H2A type 1-A;Histone H2A type 2-C 0 487223000.0 50873000.0 243250000.0 193100000.0 False True 66694995.6548328 206958048.1810734 173119864.34599456 1.0 3.103052127810986 2.595694964011143 25.991075179522305 -9.984420388929298 5.150581632686382 0.9999891307864308 2.8493735459240925 0.9465691687925432 0.20712769482127769 2.585199735853345e-05 5.097813426376251e-06 0.200551702114676 0.06685017604190373 1.0365245936510169e-10 9.984420388929298 1.8493844151376617 AGLQFPVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGLQFPVGR 9 0 Q71UI9;P0C0S5;A0A494C189;C9J0D1;Q71UI9-2;Q71UI9-5;Q8IUE6;A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;Q9BTM1-2;A0A3B3IS11;Q93077;Q7L7L0;P04908;P16104;Q96QV6;Q16777 Q71UI9;Q8IUE6;A0A0U1RR32;Q93077;P16104;Q16777 H2AFV;H2AFZ;HIST2H2AB;HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;H2AFX;HIST1H2AA;HIST2H2AC Histone H2A.V;Histone H2A.Z;Histone H2A;Histone H2A type 2-B;Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2AX;Histone H2A type 1-A;Histone H2A type 2-C 0 450705000.0 203420000.0 57395000.0 189890000.0 False True 196962543.44647834 80313122.81097095 140152112.42210862 1.0 0.4077583555006988 0.7115673364575174 27.553346056181798 -10.549127089725824 6.477921017979605 1.0005285258450376 0.559662845979134 0.736909139755095 0.1240294971031895 0.0009478127970789844 6.596902840222297e-05 0.12022768681301642 0.04003034805992782 2.8240534373664698e-11 10.549127089725824 -0.44086567986590364 AGLQFPVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGLQFPVGR 9 0 Q71UI9;P0C0S5;A0A494C189;C9J0D1;Q71UI9-2;Q71UI9-5;Q8IUE6;A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;Q9BTM1-2;A0A3B3IS11;Q93077;Q7L7L0;P04908;P16104;Q96QV6;Q16777 Q71UI9;Q8IUE6;A0A0U1RR32;Q93077;P16104;Q16777 H2AFV;H2AFZ;HIST2H2AB;HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;H2AFX;HIST1H2AA;HIST2H2AC Histone H2A.V;Histone H2A.Z;Histone H2A;Histone H2A type 2-B;Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2AX;Histone H2A type 1-A;Histone H2A type 2-C 0 574693000.0 50873000.0 275090000.0 248730000.0 False True 69682122.89113176 262935614.1990194 189985096.7551481 1.0 3.773358263062942 2.726453914901134 26.054285241045196 -10.35083199969602 6.082120039305558 0.9997465949649715 3.249906088981963 0.860299998525138 0.4273969104162478 0.0014688535243248986 0.00015677554092733957 0.413866618347485 0.13794175968855182 4.458286771789683e-11 10.35083199969602 2.2501594940169913 AGLQFPVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGLQFPVGR 9 0 Q71UI9;P0C0S5;A0A494C189;C9J0D1;Q71UI9-2;Q71UI9-5;Q8IUE6;A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;Q9BTM1-2;A0A3B3IS11;Q93077;Q7L7L0;P04908;P16104;Q96QV6;Q16777 Q71UI9;Q8IUE6;A0A0U1RR32;Q93077;P16104;Q16777 H2AFV;H2AFZ;HIST2H2AB;HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;H2AFX;HIST1H2AA;HIST2H2AC Histone H2A.V;Histone H2A.Z;Histone H2A;Histone H2A type 2-B;Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2AX;Histone H2A type 1-A;Histone H2A type 2-C 0 222397000.0 203420000.0 18977000.0 0.0 False True 169152743.03397053 18874767.134360444 0.0 1.0 0.11158416231281493 0.0 27.333751331616075 -10.680750964312502 0.4197675497052621 1.7344259208833765 1.9670758697673124e-19 0.99927863938323 0.012017114887665792 2.4890775754996377 0.2246853936298845 1.907287053222655 0.027729367897736844 2.0856865268518087e-11 10.680750964312502 -1.7344259208833765 AGLSK(ub)LPDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGLSKLPDLK 10 1 Q15388 Q15388 TOMM20 Mitochondrial import receptor subunit TOM20 homolog 1 7866440.0 1719220.0 722120.0 5425100.0 True False 2253914.0689501655 614382.5108017139 4863762.693233843 1.0 0.27258470909136423 2.157918422994405 21.10400108276569 -6.802138091986998 1.4475312662441537 0.5997384389047187 2.1852270309937163 0.8382366704615279 0.3122441345323677 0.21772610052206604 0.9004952201340919 0.16969248791453445 0.39407490037214277 1.57710971867327e-07 6.802138091986998 1.5854885920889976 AGLSK(ub)LPDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGLSKLPDLK 10 1 Q15388 Q15388 TOMM20 Mitochondrial import receptor subunit TOM20 homolog 1 11050590.0 939290.0 2944100.0 7167200.0 True False 909472.7530913515 4119694.483278676 5289895.308608865 1.0 4.529761303211769 5.816441768737105 19.794670891237367 -9.123137533525103 0.36953929274450104 1.0614133466096685e-19 6.112163484571696 0.9979803784457333 0.09150463366421355 0.5484608584431926 0.13772405601227294 1.1629504541377813 0.35089595413859337 7.531170268736383e-10 9.123137533525103 6.112163484571696 AGLSK(ub)LPDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGLSKLPDLK 10 1 Q15388 Q15388 TOMM20 Mitochondrial import receptor subunit TOM20 homolog 1 51251800.0 6561000.0 16162800.0 28528000.0 True False 9953516.673349693 13278422.059467196 22889428.29573343 1.0 1.3340432829152593 2.2996322854433284 23.246774903105134 -6.952283053004544 0.5331956332190865 0.9851121469790959 2.692637366367663 0.9993684560754511 0.013848399964142253 0.08258183090350636 0.03226764312593411 0.015378142581394602 0.07988322365441494 1.1161355652665754e-07 6.952283053004544 1.7075252193885668 up AGLSK(ub)LPDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGLSKLPDLK 10 1 Q15388 Q15388 TOMM20 Mitochondrial import receptor subunit TOM20 homolog 1 13092420.0 1719220.0 1153900.0 10219300.0 True False 2354862.094173563 1102916.8825629738 7805711.81309005 1.0 0.4683573128514948 3.314721415068451 21.167211144288583 -6.858429663536191 1.1936741369803636 0.7126800235977575 3.448461061259358 0.9517019246958256 0.27156540311911953 0.14842579236262798 0.40276410308042715 0.1775544828475375 0.41375204770633084 1.3853845386694833e-07 6.858429663536191 2.7357810376616003 up AGLSK(ub)LPDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGLSKLPDLK 10 1 Q15388 Q15388 TOMM20 Mitochondrial import receptor subunit TOM20 homolog 1 14571590.0 939290.0 2024800.0 11607500.0 True False 781061.2526023904 2013892.000508669 14034574.58298385 1.0 2.5784046946365007 17.968596619308084 19.575076166671643 -6.926611194173263 0.7740992889668409 0.7342255910564184 20.8717490360936 0.9958293414943045 0.49431387099088825 0.09443599194937662 0.08658215292635879 0.4415766085483271 1.4193781443547493 1.1841011579728147e-07 6.926611194173263 20.137523445037182 AGLSK(ub)LPDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGLSKLPDLK 10 1 Q15388 Q15388 TOMM20 Mitochondrial import receptor subunit TOM20 homolog 1 75620000.0 6561000.0 10342000.0 58717000.0 True False 8493343.83664503 9766458.60865135 48031108.48729712 1.0 1.1498955884151765 5.655147067055508 23.017901225197583 -6.913972546672768 0.8682318136215479 0.8774158867234448 6.289725571636724 0.992336599617046 0.18908768111065308 0.10184965981305256 0.12494703469575329 0.15791592259369955 0.44891305671253395 1.2190666581082108e-07 6.913972546672768 5.4123096849132795 up AGLTHLITMDLHQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGLTHLITMDLHQK 14 0 O60256-4;O60256-2;O60256;E7EPA1;O60256-3;C9JDU5;C9JJS3;C9K0K7 O60256-4 PRPSAP2 Phosphoribosyl pyrophosphate synthase-associated protein 2 0 40570700.0 13469400.0 14893800.0 12207500.0 False True 17658513.837855134 12671703.09557769 10944385.002608648 1.0 0.717597370420434 0.6197795071036393 24.073860593326003 -13.999999999999998 0.14788495316567 2.361283161511089 0.5094988001230683 0.9995734515254365 0.0033293965035452906 11.95040761441528 0.12099913089252398 4.67784065364103 0.09920431858852694 1.0000000000000041e-14 13.999999999999998 -1.851784361388021 AGLTHLITMDLHQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGLTHLITMDLHQK 14 0 O60256-4;O60256-2;O60256;E7EPA1;O60256-3;C9JDU5;C9JJS3;C9K0K7 O60256-4 PRPSAP2 Phosphoribosyl pyrophosphate synthase-associated protein 2 0 24951600.0 8224500.0 1504600.0 15222500.0 False True 7963417.749363696 2105394.6263853484 11235270.584788838 1.0 0.26438329529473403 1.4108603790987324 22.924956310621948 -6.733435351625517 1.7107929219611644 0.559005521673674 1.4106048445206614 0.5750597365853868 0.30916139723987707 0.3298450493435784 1.8928174603793377 0.14312065585595246 0.35375932035923696 1.8474157777684362e-07 6.733435351625517 0.8515993228469874 AGLTHLITMDLHQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGLTHLITMDLHQK 14 0 O60256-4;O60256-2;O60256;E7EPA1;O60256-3;C9JDU5;C9JJS3;C9K0K7 O60256-4 PRPSAP2 Phosphoribosyl pyrophosphate synthase-associated protein 2 0 15120000.0 2049200.0 9743800.0 3327000.0 False True 3108786.216587132 8004942.761343131 2669416.9917240962 1.0 2.57494153783629 0.8586685625023835 21.567919978903085 -6.665332819220082 1.953574657353368 2.0092363387044148 0.8656572929954719 0.2587765827795341 0.6697187567552892 0.4718592922715624 3.4670646381744716 0.2764121881521375 0.743120654643234 2.1610617710222978e-07 6.665332819220082 -1.1435790457089428 AGLTHLITMDLHQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGLTHLITMDLHQK 14 0 O60256-4;O60256-2;O60256;E7EPA1;O60256-3;C9JDU5;C9JJS3;C9K0K7 O60256-4 PRPSAP2 Phosphoribosyl pyrophosphate synthase-associated protein 2 0 41238800.0 13469400.0 13742600.0 14026800.0 False True 18449401.176848415 13135406.491299016 10713958.73101401 1.0 0.7119692593482239 0.5807212184457577 24.137070654848895 -13.999999999999998 0.10578786825300178 2.401430602893046 0.3246654365520034 0.9997644745649052 0.002687431389624967 12.039040061791031 0.09798191898853002 3.6339809656290294 0.22773455920456354 1.0000000000000041e-14 13.999999999999998 -2.0767651663410427 AGLTHLITMDLHQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGLTHLITMDLHQK 14 0 O60256-4;O60256-2;O60256;E7EPA1;O60256-3;C9JDU5;C9JJS3;C9K0K7 O60256-4 PRPSAP2 Phosphoribosyl pyrophosphate synthase-associated protein 2 0 16131900.0 8224500.0 3481310.0 4426090.0 False True 6839036.15712758 3462555.4920440647 5351564.955072074 1.0 0.5062929062650768 0.7825028018743143 22.705361586056224 -10.1483719430582 5.441843338829311 1.0000082515950046 0.6443978540696128 0.6884719105549868 0.11276221769196892 1.1289073874924674e-05 1.7666782509444382e-06 0.10918407977866124 0.03639384926682477 7.106046694324916e-11 10.1483719430582 -0.3556103975253918 AGLVELLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGLVELLLR 9 0 Q13425;A0A140TA73;Q13425-2 Q13425 SNTB2 Beta-2-syntrophin 0 1913410.0 670580.0 648310.0 594520.0 False True 879136.8739059578 551584.6750925867 533004.7734385325 1.0 0.6274161526656545 0.6062818990522159 19.745728272265776 -13.999999999999998 0.40863781542853994 7.639963728981327 0.6052880637829888 0.9998496217979874 0.0022174283284160045 28.088748980222892 0.21173381673760547 165.8906845569933 0.0052825370661027035 1.0000000000000041e-14 13.999999999999998 -7.034675665198338 AGLVELLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGLVELLLR 9 0 Q13425;A0A140TA73;Q13425-2 Q13425 SNTB2 Beta-2-syntrophin 0 6956080.0 670580.0 3434600.0 2850900.0 False True 918511.5477431084 3282848.015296637 2177576.136128543 1.0 3.5740955280997646 2.370766204822471 19.808938333788667 -9.014982905060878 13.061792550576877 1.0000140294516344 2.9724308664631143 0.7817734447237439 0.4912571391598128 0.0 0.0 0.47565767963767086 0.1585525598792236 9.66088905966176e-10 9.014982905060878 1.9724168370114799 AGLYWGYTVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGLYWGYTVR 10 0 Q5T280;R4GNG4 Q5T280 C9orf114 Putative methyltransferase C9orf114 0 12962300.0 3373000.0 4503400.0 5085900.0 False True 4422035.664178463 3831510.27411571 4559659.855397684 1.0 0.8664584741262005 1.0311223612089047 22.076279230011085 -6.690954582578379 1.8627917336674367 0.9163543838473853 1.0305636306609465 0.3750070080902125 0.05646755531941844 0.41461756596077115 2.7901058249944986 0.02424236554036433 0.06305834193046397 2.0372551175681495e-07 6.690954582578379 0.11420924681356115 AGLYWGYTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGLYWGYTVR 10 0 Q5T280;R4GNG4 Q5T280 C9orf114 Putative methyltransferase C9orf114 0 25207300.0 7480700.0 7782400.0 9944200.0 False True 11348768.812426014 6393569.915831261 7978724.511302308 1.0 0.5633712362552317 0.7030475854408303 23.43603245736189 -10.90057696095928 11.127121890288565 1.0287161299649328 0.6332094108480311 0.9019081427952367 0.05702263077325424 0.028426096702054163 0.0002539923787303865 0.03863598695252074 0.01840397494514568 1.257254037696782e-11 10.90057696095928 -0.3955067191169017 AGLYWGYTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGLYWGYTVR 10 0 Q5T280;R4GNG4 Q5T280 C9orf114 Putative methyltransferase C9orf114 0 12246800.0 3373000.0 3395900.0 5477900.0 False True 4620089.2518976135 3245857.9092604234 4184132.840891835 1.0 0.702553074689466 0.905638963397359 22.139489291533977 -10.151418315763122 5.07306192360551 1.000009708134987 0.8040960198719056 0.5537103132048841 0.08290946688330601 9.104077032292833e-06 1.522697161299348e-06 0.08028072384510786 0.026758915373358567 7.056375513427752e-11 10.151418315763122 -0.19591368826308142 AGLYWGYTVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGLYWGYTVR 10 0 Q5T280;R4GNG4 Q5T280 C9orf114 Putative methyltransferase C9orf114 0 9471300.0 3383200.0 2027700.0 4060400.0 False True 2813280.701172597 2016776.3776330636 4909410.866831584 1.0 0.7168770527563979 1.7450839032114016 21.423822077179707 -6.833276225771266 1.3131068409806768 0.8490237739496566 1.774670554766385 0.9122870570894864 0.12843317776104057 0.17680255542598497 0.595026357009343 0.0767658730697942 0.17667356417498611 1.467992288608126e-07 6.833276225771266 0.9256467808167285 AGLYWGYTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGLYWGYTVR 10 0 Q5T280;R4GNG4 Q5T280 C9orf114 Putative methyltransferase C9orf114 0 30960700.0 7480700.0 12811000.0 10669000.0 False True 9683913.616642356 12098056.588225922 8727351.473184483 1.0 1.249294145647347 0.9012215328094246 23.20715877945434 -6.7144386060080885 1.7791591138533014 1.152560323608999 0.9019200910810086 0.48621851410571737 0.10498163548456693 0.3662425078855828 2.2624435637579796 0.046907024454506466 0.118538893916045 1.9300181537108877e-07 6.7144386060080885 -0.2506402325279904 AGMQPGLTMVVGPPGTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGMQPGLTMVVGPPGTGK 18 0 O60306 O60306 AQR Intron-binding protein aquarius 0 21447200.0 4682200.0 3400000.0 13365000.0 False True 6413335.871697306 3249776.7577035367 10208462.260815179 1.0 0.5067217471090399 1.5917554397651534 22.612643533609415 -6.783116784217912 1.5238577213316478 0.7218228879913817 1.6011853763351198 0.7782200740457834 0.20889311900189841 0.24576267049728578 1.1274184713186508 0.10795038729406946 0.25404816630791016 1.6477192510140894e-07 6.783116784217912 0.8793624883437381 AGMSSLK(ub)G ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGMSSLKG 8 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 43880000.0 0.0 25941000.0 17939000.0 True False 0.0 22070703.917226028 16082844.3630388 0.0 AGMSSLK(ub)G ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGMSSLKG 8 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 119336000.0 24897000.0 44776000.0 49663000.0 True False 24106658.3629288 62655290.303755395 36654770.44193582 1.0 2.5990864996911665 1.5205247400985074 24.522928344295327 -10.519921530590262 5.321976219410735 0.9970470232998938 2.0598056198948416 0.562815410915086 0.44032099451341594 0.015450400295000666 0.001393729399308423 0.4269634326524133 0.14211298989465973 3.020497422105847e-11 10.519921530590262 1.0627585965949478 AGMSSLK(ub)G ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGMSSLKG 8 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 48081000.0 0.0 21055000.0 27026000.0 True False 0.0 20124720.480425857 20643015.41794169 0.0 AGMSYYNSPGLHVQHMGTSHGITRPSPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGMSYYNSPGLHVQHMGTSHGITRPSPR 28 1 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 0 12927900.0 4563000.0 1624800.0 6740100.0 False True 4418150.062659923 2273591.113220063 4974665.611334222 1.0 0.5146025103210867 1.1259612147123976 22.075010990049645 -6.695157971599812 1.848190481782903 0.6971656634255229 1.1239826973646805 0.39459756973967874 0.20507983422059375 0.4056887881497372 2.690583994579858 0.08864104948215712 0.22932930162830806 2.0176323304505514e-07 6.695157971599812 0.4268170339391576 AGMSYYNSPGLHVQHMGTSHGITRPSPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGMSYYNSPGLHVQHMGTSHGITRPSPR 28 1 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 0 10898670.0 4563000.0 5511600.0 824070.0 False True 3794336.675174556 5481907.916833059 996379.2269308228 1.0 1.4447605434435695 0.26259641993550425 21.85541626548392 -6.804765137750244 1.4361975869073507 1.2439293912057117 0.24425594743952936 0.8457880318170538 0.19144856277455413 0.21401777437079078 0.8709303565804158 0.10484141793204427 0.24316998779189586 1.567598583055928e-07 6.804765137750244 -0.9996734437661823 down AGMTHIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGMTHIVR 8 0 P39023;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 6381600.0 2044700.0 1313400.0 3023500.0 False True 1979792.117712195 1837847.4692905187 2231554.646944262 1.0 0.9283032561086744 1.1271661438489806 20.916917521603413 -6.809161165779645 1.4178745738908727 0.9608873706562588 1.1305851367377948 0.857683521972008 0.031021695098680673 0.20793750671075387 0.8240323008761075 0.017203752431258164 0.03981451689995686 1.5518110292442292e-07 6.809161165779645 0.16969776608153597 AGNAIHAILLYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGNAIHAILLYR 12 0 P50416;P50416-2;H3BMD2 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 0 10830200.0 4514300.0 3197800.0 3118100.0 False True 5918291.0165433865 2720700.704926773 2795468.9229272134 1.0 0.45971053084777413 0.472343944411156 22.496749208370595 -9.938772018311285 5.4866492332291665 1.0000008034029253 0.46602723762803694 0.9995803543380236 0.005157569494998007 5.068085516775128e-08 9.80580491938222e-09 0.00499380270329384 0.001664598396024499 1.1514046570205508e-10 9.938772018311285 -0.5339735657748883 AGNAIHAILLYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGNAIHAILLYR 12 0 P50416;P50416-2;H3BMD2 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 0 4043350.0 1127000.0 937850.0 1978500.0 False True 1091224.001888611 1312338.3958231395 1460271.4962722731 1.0 1.202629701648644 1.3381959100468297 20.057515851776213 -8.059395981220709 0.04935935536007127 4.3584246350954894e-08 2.3968895029158763 0.9999993400831376 0.00011274476465050256 0.10196514947901503 0.008507499395060918 0.19911168323010728 0.2090488600933583 8.721757729151664e-09 8.059395981220709 2.39688945933163 AGNAIHAILLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGNAIHAILLYR 12 0 P50416;P50416-2;H3BMD2 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 0 8593300.0 4514300.0 1913900.0 2165100.0 False True 6183358.704370415 1829337.56957906 1653747.971634189 1.0 0.29584852780513593 0.26745140476248214 22.559959269893486 AGNFYVPAEPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGNFYVPAEPK 11 0 P18124;A8MUD9;C9JIJ5;C9JZ88 P18124 RPL7 60S ribosomal protein L7 0 15903700.0 3490300.0 3035100.0 9378300.0 False True 3379502.3369936254 4247031.257837407 6921841.887030716 1.0 1.2567031575470156 2.0481837847132023 21.688379381271563 -6.950833842849308 0.5496151784222748 0.9890290082952924 2.3530158674720587 0.9992650923307568 0.012093338059562723 0.08315267537979447 0.03459024471895289 0.013132318444000908 0.0656552368624439 1.1198662522418977e-07 6.950833842849308 1.3639868591767663 up AGNLGGGVVTIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGNLGGGVVTIER 13 0 P35268;K7ERI7;K7EMH1;K7ELC4;K7EP65;K7EKS7;K7EJT5 P35268 RPL22 60S ribosomal protein L22 0 139965000.0 38889000.0 52131000.0 48945000.0 False True 50983855.60161168 44353258.00504642 43880640.91359242 1.0 0.8699471132905912 0.8606771770357298 25.603537144025005 -13.999999999999984 0.37494591121740745 2.8688564397747762 0.8597896892674063 0.9997992373768451 0.0009012074855594762 23.409683468222248 0.19921335526511239 35.238822013372 0.0025514055056133065 1.0000000000000368e-14 13.999999999999984 -2.00906675050737 AGNLGGGVVTIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGNLGGGVVTIER 13 0 P35268;K7ERI7;K7EMH1;K7ELC4;K7EP65;K7EKS7;K7EJT5 P35268 RPL22 60S ribosomal protein L22 0 71464000.0 18460000.0 14615000.0 38389000.0 False True 17873997.404493116 20450845.716218177 28333769.254686024 1.0 1.144167432354964 1.5851948846967807 24.091358984137127 -6.95101093326973 0.5476321125519943 0.9938133548579576 1.7561838436764419 0.999278251827778 0.006687877434733415 0.08308230974273552 0.0343017871393894 0.007281149788894047 0.03657091521184327 1.1194097022150778e-07 6.95101093326973 0.7623704888184842 AGNLGGGVVTIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGNLGGGVVTIER 13 0 P35268;K7ERI7;K7EMH1;K7ELC4;K7EP65;K7EKS7;K7EJT5 P35268 RPL22 60S ribosomal protein L22 0 202206000.0 10686000.0 175970000.0 15550000.0 False True 16211443.251244448 144566778.64011455 12476535.684192877 1.0 8.917576084968072 0.7696128895393156 23.95050919915866 -6.652694490278949 1.9987690093061776 6.12665495712499 0.8037388877395533 0.2051368855991117 3.3770629374891836 0.5019416545258514 3.846675848573162 1.3687641392381864 3.741473257485848 2.224874455202957e-07 6.652694490278949 -5.322916069385437 AGNLGGGVVTIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGNLGGGVVTIER 13 0 P35268;K7ERI7;K7EMH1;K7ELC4;K7EP65;K7EKS7;K7EJT5 P35268 RPL22 60S ribosomal protein L22 0 101058000.0 38889000.0 26213000.0 35956000.0 False True 53267314.235708944 25054822.98520083 27463933.33706476 1.0 0.47036017010981124 0.5155869735713782 25.666747205547896 -9.986295416341457 7.380257042278382 1.0000000167352767 0.4929735730539703 0.9940679069811185 0.018463765196330303 5.068450800010905e-09 6.858168582423097e-10 0.017877464311206154 0.00595915459280589 1.0320591383681764e-10 9.986295416341457 -0.5070264436813063 AGNLGGGVVTIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGNLGGGVVTIER 13 0 P35268;K7ERI7;K7EMH1;K7ELC4;K7EP65;K7EKS7;K7EJT5 P35268 RPL22 60S ribosomal protein L22 0 37886500.0 18460000.0 10058000.0 9368500.0 False True 15350307.916660583 10003815.557643311 11327410.034950193 1.0 0.6517012956323559 0.7379272192094528 23.871764259571403 -9.794018326776229 5.966835986285572 1.0000000194387975 0.694814257420214 0.9435120327716948 0.03520158589647719 9.100897925847348e-09 1.8726068737519044e-09 0.034083791014756164 0.011361262994402157 1.6068734431911745e-10 9.794018326776229 -0.3051857620185835 AGNLGGGVVTIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGNLGGGVVTIER 13 0 P35268;K7ERI7;K7EMH1;K7ELC4;K7EP65;K7EKS7;K7EJT5 P35268 RPL22 60S ribosomal protein L22 0 45655200.0 10686000.0 25236000.0 9733200.0 False True 13833237.652551254 23831594.415773127 7961857.471065633 1.0 1.722777777289027 0.5755599427294762 23.72163552125111 -6.736421361350953 1.699910828866039 1.4318224044785766 0.5754120577963358 0.5887424035114832 0.30371617969250064 0.3243198733076686 1.838752030987601 0.14142855083442252 0.3484105832045665 1.8347573605582618e-07 6.736421361350953 -0.8564103466822408 AGNNMLLVGVHGPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGNNMLLVGVHGPR 14 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 57771000.0 16916000.0 16508000.0 24347000.0 False True 22177039.814777024 14045070.747680025 21827805.9929152 1.0 0.6333158467038285 0.9842524599866064 24.40256347202176 -10.654050681649199 9.40869880012446 1.00010631411865 0.808784153760358 0.2835899358821111 0.14326927243387189 0.0003196795071988664 1.1754292806394983e-05 0.138796269346037 0.04623995884663662 2.217937574021619e-11 10.654050681649199 -0.19132216035829197 AGNNMLLVGVHGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGNNMLLVGVHGPR 14 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 45631700.0 14034000.0 5806700.0 25791000.0 False True 13588498.351823218 8125345.5915404605 19035563.386584915 1.0 0.5979575800920087 1.400858497659592 23.695882698677575 -6.77055674041666 1.5722808697642408 0.7695637685939782 1.4054742971222336 0.732702282701522 0.16946659800639138 0.2655294279792238 1.2955117279126 0.0849533336090605 0.2021245065471998 1.6960679971149638e-07 6.77055674041666 0.6359105285282554 AGNNMLLVGVHGPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGNNMLLVGVHGPR 14 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 96904000.0 13844000.0 19225000.0 63835000.0 False True 21002360.13196968 15794148.544389397 51217984.27012561 1.0 0.752017794435761 2.438677555679177 24.32404812350133 -6.86953321536813 1.1366229016213194 0.8601506221171672 2.5365586211379303 0.9642119719074251 0.14066711844924784 0.13730000024109165 0.3318227103442779 0.09607698237224929 0.2272736985978173 1.3504135426416134e-07 6.86953321536813 1.6764079990207632 up AGNNMLLVGVHGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGNNMLLVGVHGPR 14 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 53213000.0 16916000.0 15933000.0 20364000.0 False True 23170302.337711256 15229027.37661482 15554442.609744854 1.0 0.6572649400361312 0.6713094366675109 24.465773533544652 -9.778167344684846 6.173697765880429 1.0000000096104227 0.664287188358327 0.9986891030860902 0.005733641741628404 7.614149029073857e-10 1.4739530418599472e-10 0.005551574909425961 0.0018505249146587481 1.6666049036477123e-10 9.778167344684846 -0.3357128212520957 AGNYEEALQLYQHAVQYFLHVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGNYEEALQLYQHAVQYFLHVVK 23 0 O75351;K7EL71;K7EKZ3 O75351 VPS4B Vacuolar protein sorting-associated protein 4B 0 1627817300.0 560387300.0 441720000.0 625710000.0 False True 850148503.899316 362891614.82588744 502038144.241565 1.0 0.4268567352191272 0.5905299391093464 29.66313963226192 -10.757444349814676 10.543170099649492 1.0013615925776416 0.5086933371643304 0.9231598776940062 0.06681930568292527 0.0021421511743312653 4.928209603390224e-05 0.06480599686939853 0.021565838176259358 1.748057242876561e-11 10.757444349814676 -0.49266825541331116 AGNYEEALQLYQHAVQYFLHVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGNYEEALQLYQHAVQYFLHVVK 23 0 O75351;K7EL71;K7EKZ3 O75351 VPS4B Vacuolar protein sorting-associated protein 4B 0 1502977300.0 560387300.0 443540000.0 499050000.0 False True 725432406.7351234 418856609.0970044 408228020.68541735 1.0 0.5773888858675447 0.5627375023438584 29.43426595435437 AGPAALSAAAAAALAAALLLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGPAALSAAAAAALAAALLLLR 22 0 Q9BUP3-3 Q9BUP3-3 HTATIP2 Oxidoreductase HTATIP2 0 8618900.0 2588700.0 3533100.0 2497100.0 False True 3927247.159320279 2902590.7007637024 2003547.0904821898 1.0 0.7390904068452054 0.5101657749569701 21.90508696547083 -6.972661660511114 0.18380674044394887 1.168288041209934 0.07475388658778138 0.9999963883135802 0.00038026545273946323 0.07544812297794082 0.005821755417610643 0.008525602324261809 0.02539992102033954 1.0649723676692503e-07 6.972661660511114 -1.0935341546221524 AGPALLK(ub)HQQLHSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGPALLKHQQLHSR 14 1 Q5XUX1 Q5XUX1 FBXW9 F-box/WD repeat-containing protein 9 1 6197840.0 894440.0 942400.0 4361000.0 True False 866046.4917917035 1318705.2345510768 3218723.2728043403 1.0 1.522672566715095 3.71657099625835 19.7240849493622 -6.943768822537222 0.62351531881014 0.97603600326269 4.380139535367638 0.9986170502208372 0.043767108679714194 0.08608854875161658 0.047090292111419546 0.043936516066552266 0.18591948438882433 1.1382330126043691e-07 6.943768822537222 3.4041035321049478 AGPESDAQYQFTGIK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGPESDAQYQFTGIKK 16 1 Q96IX5 Q96IX5 USMG5 Up-regulated during skeletal muscle growth protein 5 1 26429900.0 2941500.0 5415400.0 18073000.0 True False 3856334.985526522 4607443.4290638715 16202979.328457577 1.0 1.1947726134675505 4.201652447017725 21.878798947906265 -6.920077976298732 0.8241492650763275 0.9338392273114109 4.687407326457956 0.9942024175318501 0.11158770718399703 0.09812636055438329 0.10537749115354246 0.09618337976226547 0.2883296078039218 1.2020485909467766e-07 6.920077976298732 3.753568099146545 up AGPESDAQYQFTGIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGPESDAQYQFTGIKK 16 1 Q96IX5 Q96IX5 USMG5 Up-regulated during skeletal muscle growth protein 5 1 17018900.0 5275800.0 6943700.0 4799400.0 True False 5108322.616826912 9716355.62091715 3542293.161086256 1.0 1.9020638181526142 0.6934356787525272 22.284418210848482 -6.706912540018205 1.8064252514577523 1.5563063461441684 0.6965440372002719 0.45039272454506485 0.38031206126232514 0.38128050078198084 2.423398356818035 0.16767260711993598 0.42753537310245937 1.9637557060960584e-07 6.706912540018205 -0.8597623089438965 AGPESDAQYQFTGIK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGPESDAQYQFTGIKK 16 1 Q96IX5 Q96IX5 USMG5 Up-regulated during skeletal muscle growth protein 5 1 24479800.0 2941500.0 3987300.0 17551000.0 True False 4029052.0410485747 3811127.9017621456 13405815.274191327 1.0 0.9459118082699886 3.327287693882062 21.942009009429157 -6.901703862982999 0.9504335106668912 0.9055665258745746 3.5860858695344517 0.9873950936024153 0.12462844109469959 0.11016195486214965 0.17043087928226314 0.09802259666496647 0.25728886583588145 1.2539959590962414e-07 6.901703862982999 2.680519343659877 up AGPESDAQYQFTGIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGPESDAQYQFTGIKK 16 1 Q96IX5 Q96IX5 USMG5 Up-regulated during skeletal muscle growth protein 5 1 16172600.0 5275800.0 8688800.0 2208000.0 True False 4387061.457568685 8641991.709808243 2669682.5913614775 1.0 1.9698816151524001 0.608535489457451 22.06482348628276 -6.715388307200361 1.7757992842672108 1.5929483233716848 0.6111733416997672 0.49071690535785706 0.40837727316267447 0.3643582210961324 2.242866206101236 0.18277616912292602 0.46136320506092493 1.925802263409867e-07 6.715388307200361 -0.9817749816719176 AGPGTLSVTIEGPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGPGTLSVTIEGPSK 15 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7 O75369-2 FLNB Filamin-B 0 6426600.0 1884800.0 2315600.0 2226200.0 False True 2470991.052429164 1970121.5061381059 1995854.1792182957 1.0 0.7973001376113172 0.807714045445946 21.236658355936058 -9.862629908364518 6.18857299983681 1.0000000180656587 0.8025070915299379 0.9979189535032821 0.004251460070775028 1.0635240630825381e-09 1.883245886545203e-10 0.0041164589420686305 0.0013721528375629298 1.372050484930222e-10 9.862629908364518 -0.19749292653572081 AGQAVDDFIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGQAVDDFIEK 11 0 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 23555700.0 5300900.0 2016800.0 16238000.0 False True 5132625.831065964 2822118.7574730604 11984780.670441855 1.0 0.549839175961703 2.335019357519153 22.291265661093917 -6.839886736063692 1.2829452874682763 0.7605251012392891 2.393595047706958 0.9242570148945943 0.20862693776300692 0.16892986227624895 0.5401677815393028 0.12751541590152354 0.29375788963035665 1.445816790384422e-07 6.839886736063692 1.6330699464676688 up AGQCVIGLQMGTNK ddPTM_RPMI8226_Bortezomib_1h_R1 2 AGQCVIGLQMGTNK 14 0 B4DDF4;B4DUT8;Q99439;A0A087X271;H3BVI6;A0A087X1X5 B4DDF4 CNN2 Calponin;Calponin-2 0 40966500.0 14230500.0 11813500.0 14922500.0 False True 18656323.308358025 10050971.84866233 13378462.846727623 1.0 0.538743442774681 0.7171007183786355 24.15316135954157 -10.105239730153736 5.15964793268424 1.0000089946842299 0.62792208057606 0.8529980290701329 0.0728140528591923 7.534121309327628e-06 1.3064302566610243e-06 0.07050360672999288 0.023500634507493345 7.848023048733034e-11 10.105239730153736 -0.37208691410816985 AGQCVIGLQMGTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AGQCVIGLQMGTNK 14 0 B4DDF4;B4DUT8;Q99439;A0A087X271;H3BVI6;A0A087X1X5 B4DDF4 CNN2 Calponin;Calponin-2 0 35091100.0 14230500.0 8981000.0 11879600.0 False True 19491900.414802548 8584189.72380455 9073883.148041895 1.0 0.44039778272648783 0.46552070116010863 24.216371421064462 -10.4194452785661 5.962575199691769 1.0001889811559739 0.4529592419433032 0.9984206595230242 0.010256388501989601 2.5774818277756173e-05 2.5096219857026567e-06 0.00993406856472152 0.0033102351550364575 3.8067531995834946e-11 10.4194452785661 -0.5472297392126706 AGQCVIGLQMGTNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGQCVIGLQMGTNK 14 0 B4DDF4;B4DUT8;Q99439;A0A087X271;H3BVI6;A0A087X1X5 B4DDF4 CNN2 Calponin;Calponin-2 0 14850700.0 8649100.0 1769800.0 4431800.0 False True 7192109.870096924 1760265.7361222068 5358468.889672016 1.0 0.24474956138267182 0.7450482523843595 22.777983629641668 -9.865726330944831 5.970964356708127 1.0000000852453463 0.49489890688772803 0.5761012152753043 0.20424608532424063 2.3178871658926689e-07 4.392433156631641e-08 0.19776045416173554 0.06592014058218501 1.3623028621383213e-10 9.865726330944831 -0.5051011783576183 AGQCVIGLQMGTNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGQCVIGLQMGTNK 14 0 B4DDF4;B4DUT8;Q99439;A0A087X271;H3BVI6;A0A087X1X5 B4DDF4 CNN2 Calponin;Calponin-2 0 22166200.0 6362900.0 10100000.0 5703300.0 False True 8236899.4815102285 9537926.121386465 4665357.920799803 1.0 1.1579510157671238 0.5663973357053051 22.973669952312488 -6.835668540330128 1.3024148155855675 1.0841268707619587 0.5485575159992611 0.9167364868930535 0.0721639035282374 0.17392046405426997 0.5749456238411089 0.043476129730521326 0.10007108968879438 1.4599280728651177e-07 6.835668540330128 -0.5355693547626976 AGQERPSVTSYK(ub)EVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGQERPSVTSYKEVLR 16 2 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 17408300.0 2860100.0 4378400.0 10169800.0 True False 3749618.7972478014 3725159.786869523 9117526.651610028 1.0 0.9934769341362831 2.4315876212009178 21.838312501659395 -6.905879325428325 0.9233510251349133 0.9494653159444922 2.601939291340555 0.9892711368472321 0.07006162507721952 0.10720605826178439 0.15401932600222107 0.05621646350737786 0.15108852622896296 1.2419973653481894e-07 6.905879325428325 1.6524739753960627 up AGQERPSVTSYK(ub)EVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGQERPSVTSYKEVLR 16 2 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 94829200.0 10370600.0 7644600.0 76814000.0 True False 15732958.392415818 6280361.402467577 61631679.23122772 1.0 0.39918502584326854 3.917361102342818 23.907286641815983 -6.8629249160872785 1.1709472785834805 0.6711616436223408 4.097430692436428 0.9570930842202441 0.3182857047640283 0.14381456500838988 0.3730569579985119 0.21174860883843669 0.4960009120259804 1.3711187944242948e-07 6.8629249160872785 3.4262690488140874 up AGQERPSVTSYK(ub)EVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGQERPSVTSYKEVLR 16 2 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 23598700.0 2860100.0 4756100.0 15982500.0 True False 3917556.2612962876 4545959.775680522 12207762.66991983 1.0 1.1604070171480578 3.1161677984122633 21.901522563182287 -6.923166038145666 0.8009022871883764 0.961570972744181 3.4557148008738006 0.9950160420036563 0.0679140563811169 0.09634439262018858 0.09622445790695938 0.05951839582492365 0.18405727643730616 1.193531709812264e-07 6.923166038145666 2.4941438281296193 up AGQERPSVTSYK(ub)EVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGQERPSVTSYKEVLR 16 2 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 72587600.0 10370600.0 14865000.0 47352000.0 True False 13424946.135087762 14037749.682614807 38734421.87254961 1.0 1.0456466298904104 2.885257153569681 23.678412963908432 -6.912234470845445 0.8803851925671183 0.9469881418232465 3.1347149805161703 0.9917377356397954 0.07982187900247782 0.10295876782628416 0.13089123449981918 0.06608201640459385 0.18536669071401804 1.2239552208034589e-07 6.912234470845445 2.1877268386929236 up AGQMVTVWAAGAGVAHSPPSTLVWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGQMVTVWAAGAGVAHSPPSTLVWK 25 0 Q03252 Q03252 LMNB2 Lamin-B2 0 27736100.0 4684100.0 11139000.0 11913000.0 False True 7106122.153579828 9151158.420595763 9558390.3283466 1.0 1.2877851270802758 1.3450923192379125 22.760631058000225 -12.757998030011992 0.24558735383649102 4.54016838114422e-10 1.3703226947471656 0.9994513808094718 0.003536674111308654 7.5754021947547505 0.1503713329193307 3.749099060113028 0.027104115040648965 1.745830072101266e-13 12.757998030011992 1.3703226942931488 AGQMVTVWAAGAGVAHSPPSTLVWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGQMVTVWAAGAGVAHSPPSTLVWK 25 0 Q03252 Q03252 LMNB2 Lamin-B2 0 10585100.0 3191700.0 3371600.0 4021800.0 False True 2654039.966284162 3353436.5215897956 4862739.785297828 1.0 1.2635214858067254 1.8322029234947796 21.339758665249246 -6.958531175569354 0.4556679079793022 0.9826871317243691 2.1357959258229755 0.9997117667839694 0.005895847356498639 0.08023012614946143 0.02310249045131101 0.007668117032297161 0.04700271421001248 1.100192865774879e-07 6.958531175569354 1.1531087940986064 AGQMVTVWAAGAGVAHSPPSTLVWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGQMVTVWAAGAGVAHSPPSTLVWK 25 0 Q03252 Q03252 LMNB2 Lamin-B2 0 21917000.0 4684100.0 9970900.0 7262000.0 False True 6063659.7874148665 9416010.649874473 5940390.514412386 1.0 1.5528593258839183 0.9796708131187826 22.531757380092674 -6.6544043969330176 1.9930772384332958 1.3574962171800036 0.9820892536691888 0.212043531263588 0.23571321041718446 0.497795605502322 3.7952304189945063 0.09575654719876427 0.2611154534133213 2.2161318890345297e-07 6.6544043969330176 -0.3754069635108148 AGQVVTIWAAGAGATHSPPTDLVWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGQVVTIWAAGAGATHSPPTDLVWK 25 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 22916400.0 11433000.0 4269900.0 7213500.0 False True 11070065.673107805 5974893.337234334 5324067.949638643 1.0 0.5397342268482628 0.4809427610327778 23.400160445137317 -13.999999999999998 0.29013205918678886 4.969050660863562 0.4649431957027567 0.9996277575673027 0.004477518987137951 15.973694221505545 0.17081680607132407 37.844117084924775 0.022190933421347772 1.0000000000000041e-14 13.999999999999998 -4.504107465160805 AGQVVTIWAAGAGATHSPPTDLVWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGQVVTIWAAGAGATHSPPTDLVWK 25 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 58245600.0 9049600.0 33356000.0 15840000.0 False True 13728904.814379727 27403361.188382454 12709217.057081368 1.0 1.9960340288527625 0.9257269409989402 23.71071320725792 -6.662341236564803 1.9647742885264305 1.6398963211033915 0.9301842238991308 0.24557185192889597 0.42385248626453004 0.4788861289091285 3.5562643113035173 0.1741488833167282 0.46993601352780134 2.1759993607152115e-07 6.662341236564803 -0.7097120972042607 AGQVVTIWAAGAGATHSPPTDLVWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGQVVTIWAAGAGATHSPPTDLVWK 25 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 12016200.0 3595600.0 2943700.0 5476900.0 False True 4924990.487436422 2813637.6004858552 4183369.0202961913 1.0 0.5712980781716032 0.8494166701373137 22.23168950734668 -10.44007014487376 6.798279427256906 1.0000452171162248 0.7103573741544587 0.5911889286702599 0.113541439716218 7.782611161458022e-05 6.410085690619695e-06 0.10995313275047056 0.036645342093777136 3.630194171204022e-11 10.44007014487376 -0.2896878429617662 AGQVVTIWAAGAGATHSPPTDLVWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGQVVTIWAAGAGATHSPPTDLVWK 25 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 16191900.0 11433000.0 4758900.0 0.0 False True 9507046.067777935 4733262.861132303 0.0 1.0 0.4978689308316984 0.0 23.180565720571593 -7.935305738258408 0.591629370592199 1.0109025331985553 1.8497457820489602e-18 0.9890517236655705 0.04271678520877663 0.11229182849581554 0.1618763811668843 0.044978313102000976 0.07693361465662572 1.1606312552791238e-08 7.935305738258408 -1.0109025331985553 AGQVVTIWAAGAGATHSPPTDLVWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGQVVTIWAAGAGATHSPPTDLVWK 25 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 33326600.0 9049600.0 14127000.0 10150000.0 False True 11714885.594284844 13340820.031368958 8302804.147794778 1.0 1.1387921737688445 0.708739669796292 23.48183952935037 -6.8198352139161145 1.372628257416685 1.0748193294188761 0.6993869968242901 0.884002015157721 0.06103566688771007 0.1936906796813881 0.7171273180995287 0.03494368380113717 0.0805414900337807 1.5141356539727096e-07 6.8198352139161145 -0.3754323325945861 AGSDFHIGHK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGSDFHIGHK 10 0 J3KSW2;Q9UNA4;X6R2I3;J3KQ09 J3KSW2 POLI DNA polymerase iota 1 66248900.0 21514400.0 24496300.0 20238200.0 True False 28205586.74574598 20841547.525829524 18144145.20252256 1.0 0.7389155812889758 0.643281962757222 24.74947761308033 -13.999999999999998 0.13963001794482924 2.2467534481212503 0.524401151722047 0.9996044117935351 0.0029985307148401746 11.933605166050112 0.1170470680739763 4.054657808026504 0.1062514136137446 1.0000000000000041e-14 13.999999999999998 -1.7223522963992033 AGSDFHIGHK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGSDFHIGHK 10 0 J3KSW2;Q9UNA4;X6R2I3;J3KQ09 J3KSW2 POLI DNA polymerase iota 1 59725300.0 13098000.0 21381600.0 25245700.0 True False 12682211.159482723 29919384.383570984 18633093.815234233 1.0 2.359161506406531 1.469230687055855 23.59630296731594 -10.108790404392812 4.831459538880038 0.9999547940662397 1.9141960967382092 0.5845511552259319 0.3633127356551981 0.00017692040923476124 3.263513215568893e-05 0.3517933450890342 0.11725868121802993 7.784121312208537e-11 10.108790404392812 0.9142413026719696 AGSDFHIGHK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGSDFHIGHK 10 0 J3KSW2;Q9UNA4;X6R2I3;J3KQ09 J3KSW2 POLI DNA polymerase iota 1 79623100.0 31340300.0 26158000.0 22124800.0 True False 47545526.38283511 21489900.526613165 17751823.58235569 1.0 0.45198575263584523 0.37336475022736215 25.502806266729035 -13.999999999999998 0.27348697049620574 5.310090969842408 0.34813697035799435 0.9995908727852493 0.005637673319842298 15.056939680338004 0.1655813115526541 36.15734227889338 0.03209382907892969 1.0000000000000041e-14 13.999999999999998 -4.961953999484414 AGSDFHIGHK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGSDFHIGHK 10 0 J3KSW2;Q9UNA4;X6R2I3;J3KQ09 J3KSW2 POLI DNA polymerase iota 1 51124500.0 21514400.0 12543100.0 17067000.0 True False 29468855.084798723 11988904.367515082 13036126.10589842 1.0 0.406833055882767 0.44236961593472296 24.81268767460322 -9.97671299231344 5.702097743975364 1.000000841562364 0.42460133590838944 0.9971474465775673 0.014507739891434836 1.5521498123527294e-07 2.7880458053042308e-08 0.01404707936312636 0.004682352915703204 1.055083928410415e-10 9.97671299231344 -0.5753995056539746 AGSDFHIGHK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGSDFHIGHK 10 0 J3KSW2;Q9UNA4;X6R2I3;J3KQ09 J3KSW2 POLI DNA polymerase iota 1 72328100.0 13098000.0 31529100.0 27701000.0 True False 10891567.339784427 31359246.480263636 33493151.025047258 1.0 2.879222567510134 3.07514519996625 23.376708242750215 -10.336074160815418 0.4757822151651336 9.761475690677024e-20 3.073451802464361 0.999432854546042 0.022278262341652828 1.6964593158487438 0.22287636512014494 2.2197362550920103 0.04165669789755357 4.612388059642616e-11 10.336074160815418 3.073451802464361 AGSDFHIGHK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGSDFHIGHK 10 0 J3KSW2;Q9UNA4;X6R2I3;J3KQ09 J3KSW2 POLI DNA polymerase iota 1 68442700.0 31340300.0 23072800.0 14029600.0 True False 40570636.159671694 21788778.39737877 11476356.755852384 1.0 0.5370578442897921 0.2828734730874196 25.273932588821484 -9.16172348291765 0.1898421278809416 1.4470853392551055 9.633107455083792e-22 0.999619613527159 0.0057900352402758945 0.6013191326407423 0.0663463630207385 0.3070774074088345 0.14710510560356838 6.890909037096837e-10 9.16172348291765 -1.4470853392551055 AGSTALYWACHGGHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGSTALYWACHGGHK 15 0 Q92882 Q92882 OSTF1 Osteoclast-stimulating factor 1 0 19231600.0 5497700.0 7214800.0 6519100.0 False True 7207537.939802529 6138379.963070128 5844566.067622847 1.0 0.8516611378723185 0.8108963305412688 22.78107509527549 -13.999999999993664 0.18124469122309214 1.7726263305038146 0.7789274550011882 0.9994966852803653 0.0018229973677589095 12.221069412798252 0.13496919133124793 3.326164421261889 0.03011747246930497 1.0000000000145898e-14 13.999999999993664 -0.9936988755026264 AGSTALYWACHGGHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGSTALYWACHGGHK 15 0 Q92882 Q92882 OSTF1 Osteoclast-stimulating factor 1 0 16748200.0 3607000.0 7919400.0 5221800.0 False True 4669332.604599696 7478678.4282879075 4271485.980192592 1.0 1.6016589653349524 0.9147958267065426 22.154784927215903 -6.675318863969216 1.9188661291459075 1.3822692606966978 0.9175174848196169 0.30272426170255584 0.2552629941414692 0.44898245747184234 3.192119918869882 0.10691365447607196 0.28364402459764665 2.1119378615589707e-07 6.675318863969216 -0.46475177587708083 AGTAGWNEPQMVFPNIVNYLPCK(ub)ENPGPSYAR ddPTM_RPMI8226_Bortezomib_2h_R1 2 AGTAGWNEPQMVFPNIVNYLPCKENPGPSYAR 32 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 441840300.0 340128000.0 44583000.0 57129300.0 True False 329330822.8166546 62385224.39727361 42165422.487737015 1.0 0.18943026305194874 0.12803363537949616 28.294962302443462 -13.743210314620919 0.36834098696072914 9.998318478562053 0.12142596398613933 0.9997814962408701 0.005873853228389369 18.629206592245673 0.19639505277700645 131.2127011349728 0.017256066332489207 1.806299182526838e-14 13.743210314620919 -9.876892514575914 AGTAGWNEPQMVFPNIVNYLPCK(ub)ENPGPSYAR ddPTM_RPMI8226_Bortezomib_8h_R1 2 AGTAGWNEPQMVFPNIVNYLPCKENPGPSYAR 32 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 1696760300.0 450390300.0 520736000.0 725634000.0 True False 683275013.041452 427806592.27106196 582212121.84332 1.0 0.6261118643381568 0.8520904624504381 29.347891128381356 -10.304089694344405 5.753699517968734 1.0000258471910128 0.7391011633942958 0.6399315216356685 0.09225537636076507 3.0591220741198126e-05 3.6998551009209125e-06 0.08933472301158137 0.029775294686944172 4.964897713942642e-11 10.304089694344405 -0.26092468379671707 AGTAGWNEPQMVFPNIVNYLPCK(ub)ENPGPSYAR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AGTAGWNEPQMVFPNIVNYLPCKENPGPSYAR 32 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 543855500.0 340128000.0 77741900.0 125985600.0 True False 282831502.22524047 77323088.95414108 152328606.46840146 1.0 0.2733892382771519 0.5385842993793898 28.07536757787774 -10.32821679705776 5.7447226170503445 1.0000821462909295 0.4059867688292434 0.8699542132442333 0.10826543033445854 0.00011392206480158001 1.3321860003290766e-05 0.104841923452446 0.03494251738794327 4.69659598976762e-11 10.32821679705776 -0.5940953774616862 AGTAGWNEPQMVFPNIVNYLPCK(ub)ENPGPSYAR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AGTAGWNEPQMVFPNIVNYLPCKENPGPSYAR 32 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 1668127300.0 450390300.0 761823000.0 455914000.0 True False 583039121.8700964 719426880.3537621 372942330.07268107 1.0 1.2339255692588902 0.6396523253473446 29.119017450473805 -6.799936170316892 1.4563067607519227 1.1290774174678901 0.631474088388277 0.8319393789356025 0.10020624577611047 0.22084950031889525 0.9247337544410001 0.05413309609700777 0.12589101702751856 1.5851261465256034e-07 6.799936170316892 -0.49760332907961313 AGTEDEEEEEEGRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGTEDEEEEEEGRR 14 1 O95456;O95456-2;F8WBH7 O95456 PSMG1 Proteasome assembly chaperone 1 0 6133660.0 1922500.0 629260.0 3581900.0 False True 1861471.289823295 880526.7995475486 2643692.9353033393 1.0 0.4730273329282102 1.420216873478773 20.82801193445318 -6.755733136828608 1.6288593841271086 0.6922814814895195 1.4229277140114036 0.6731837943193246 0.22152900593051097 0.29014323473582726 1.516217785265631 0.10736750503858768 0.25908617386981064 1.754958549026993e-07 6.755733136828608 0.7306462325218841 AGTFQAFEQFGQQLLAHGHYASPEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGTFQAFEQFGQQLLAHGHYASPEIK 26 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 16630300.0 8152400.0 2339500.0 6138400.0 False True 7893606.524398142 3273674.550331332 4530568.891947302 1.0 0.4147248206776987 0.5739542347270395 22.91225317577997 -10.594380436070775 9.837310339610859 1.0000517193997391 0.49433952770254497 0.9307792142212067 0.065005136077206 7.374341537800664e-05 3.0407376882693098e-06 0.0629473038847145 0.02098031745374714 2.5446002407286255e-11 10.594380436070775 -0.5057121916971942 AGTFQAFEQFGQQLLAHGHYASPEIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGTFQAFEQFGQQLLAHGHYASPEIK 26 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 17118700.0 8152400.0 1860900.0 7105400.0 False True 6779081.8125559995 1850874.9623402702 8591106.288342318 1.0 0.27302738239744184 1.2672964460216638 22.692658451214246 -6.710700878701749 1.7927747878387204 0.5533944796788599 1.2650036222145307 0.46841699126826863 0.3063084178203089 0.3736591853894976 2.3415065800585793 0.13594676409998227 0.34506662729493137 1.9467004142666304e-07 6.710700878701749 0.7116091425356708 AGTGENAPWVVEDELVK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGTGENAPWVVEDELVKK 18 1 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 11481900.0 2596800.0 3139300.0 5745800.0 True False 2159354.257745623 3122387.967797741 6947220.214422463 1.0 1.445982268355323 3.217267472209677 21.042168516698876 -6.945038043589269 0.6108969244441846 0.9804321657428868 3.7752027531559578 0.9987520969390943 0.03382713830103343 0.08554153458103339 0.04469491606821263 0.034355373209868305 0.14940660371386613 1.1349113946667685e-07 6.945038043589269 2.794770587413071 up AGVAFFHLQDYDQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGVAFFHLQDYDQAR 15 0 E9PKV8;Q8N5M4;H0YDR3 E9PKV8 TTC9C Tetratricopeptide repeat protein 9C 0 13275700.0 4212300.0 2984800.0 6078600.0 False True 4078582.8421964413 4176646.205526375 4486432.305908844 1.0 1.024043489399157 1.0999978373597932 21.95963652502752 -6.950284320322821 0.5557183726678447 0.9989834475707936 1.1286612505860527 0.9992233543637314 0.0011876825641555285 0.08337187970459006 0.035492146507126954 0.0012798135130285863 0.0063081503654126465 1.1212841409249161e-07 6.950284320322821 0.1296778030152591 AGVENGKPTHFTVYTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGVENGKPTHFTVYTK 16 1 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 4572100.0 1443100.0 1451200.0 1677800.0 False True 1976653.0683111332 1387081.1855233437 1281538.1953756583 1.0 0.7017322400983983 0.6483374426806288 20.91462824840925 -13.999999999999998 0.24196392107520548 2.993201992903672 0.6251650777114572 0.9995282611746337 0.003360730004898931 13.693639660007745 0.155678370797532 13.203304268896204 0.02579316589310361 1.0000000000000041e-14 13.999999999999998 -2.368036915192215 AGVETTTPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGVETTTPSK 10 0 P0DOY2;P0DOY3 P0DOY2 0 181418400.0 1659400.0 101220000.0 78539000.0 False True 2175489.4696524595 86118370.55246964 70412537.67928559 1.0 39.58574461232731 32.36629671691042 21.052908602926614 -9.818090210781333 9.853405822217557 1.0000001208721785 35.976019559992835 0.9690352196179317 2.9473272613970187 0.0 0.0 2.853737689995631 0.9512457832678761 1.5202317174413035e-10 9.818090210781333 34.976019439120655 AGVETTTPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGVETTTPSK 10 0 P0DOY2;P0DOY3 P0DOY2 0 98598000.0 38596000.0 12486000.0 47516000.0 False True 37370791.10638226 17471724.913629822 35070134.150555134 1.0 0.4675235497127586 0.9384370282855956 25.155407768823263 -10.328772084762832 8.397473733186544 1.0000006857510542 0.7029802889991777 0.34658832359695657 0.1922496225837517 2.468105379599517e-06 1.9752668941522884e-07 0.1861453265483443 0.062048298881794264 4.6905947727102475e-11 10.328772084762832 -0.2970203967518764 AGVETTTPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGVETTTPSK 10 0 P0DOY2;P0DOY3 P0DOY2 0 169134400.0 1659400.0 89607000.0 77868000.0 False True 2272925.0235988456 85647866.44927666 59477182.14179986 1.0 37.68178253133301 26.167683282234453 21.116118664449505 -9.423663564356948 10.059090519059309 1.000131466962416 31.924732906783394 0.905821472176579 4.70061133528861 0.0 0.0 4.5513467440617985 1.5171157847882406 3.769957338171509e-10 9.423663564356948 30.92460143982098 AGVETTTPSK(ub)QSNNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGVETTTPSKQSNNK 15 1 P0DOY2;P0DOY3 P0DOY2 1 210486600.0 2788600.0 19518000.0 188180000.0 True False 4230510.073967836 16034860.405169955 150986140.51777595 1.0 3.7902900890933715 35.689819401887064 22.01240018936429 -6.924104369469151 0.7936859941761432 0.39472196737703946 41.35316519069219 0.9952472914171319 1.0848756064591945 0.09581661210846716 0.093536377220955 0.9556597845387602 2.985365462222381 1.1909557636402073e-07 6.924104369469151 40.95844322331515 AGVETTTPSK(ub)QSNNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGVETTTPSKQSNNK 15 1 P0DOY2;P0DOY3 P0DOY2 1 173837600.0 2788600.0 10669000.0 160380000.0 True False 3609897.6715239054 10075260.771195251 131192485.63776621 1.0 2.7910100750700826 36.34243892081954 21.78352651145674 -6.91793837459119 0.8398669502511226 0.2032700210885371 41.504547936434086 0.9935889272080196 1.3015159182129 0.0994004170986189 0.11200944236794239 1.109312613826667 3.2602011853378854 1.2079852333298153e-07 6.91793837459119 41.30127791534555 up AGVK(ub)ATLNAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGVKATLNAR 10 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 3307350.0 1032200.0 1575400.0 699750.0 True False 1353224.1958390195 1340356.4608611031 627346.5824759692 1.0 0.9904910546105494 0.46359397386255335 20.367969447389648 -6.910812667328547 0.8901841229672202 1.0158974611384677 0.3943047286719847 0.9912246076039336 0.023480437371437582 0.1038830367711611 0.13587107702370158 0.019301325736396806 0.05358509719305166 1.22796880056134e-07 6.910812667328547 -0.621592732466483 down AGVK(ub)ATLNAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGVKATLNAR 10 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 5391900.0 1220600.0 1510600.0 2660700.0 True False 1851739.4378129272 1241021.6276283308 2134811.4787737597 1.0 0.6701923619956436 1.1528681817649067 20.82044967752191 -6.722783398997096 1.7494159424177222 0.7999434029636878 1.1522290003995925 0.5255293148298554 0.1387394232245386 0.34995671895805147 2.094612925602843 0.06293562359553367 0.15747017352478457 1.8932876457344946e-07 6.722783398997096 0.3522855974359047 AGVK(ub)ATLNAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGVKATLNAR 10 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 3164540.0 1032200.0 1167800.0 964540.0 True False 1413832.2341561578 1116202.7346018194 736735.5173248539 1.0 0.7894874000153365 0.521091187148221 20.43117950891254 -6.967817429818777 0.30585943327089277 1.0434234444401247 0.25867440841729544 0.9999600040636956 0.0012394678286157463 0.07701743629984184 0.011551809014513047 0.0043284392746314815 0.023926065397027272 1.0769178368432987e-07 6.967817429818777 -0.7847490360228293 AGVK(ub)ATLNAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGVKATLNAR 10 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 5553450.0 1260400.0 3480800.0 812250.0 True False 1048078.4451873789 3462048.2395152957 982087.7195803273 1.0 3.303233889994121 0.9370364633391028 19.999315271168445 -6.652296975015104 2.0000857804967063 2.4918140016046006 0.9469206402358927 0.20354760262915939 0.9824853115054243 0.5029027531101454 3.858639627864677 0.39800259820094536 1.0885424624403766 2.2269118433753283e-07 6.652296975015104 -1.544893361368708 AGVK(ub)ATLNAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGVKATLNAR 10 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 4622220.0 1220600.0 2526500.0 875120.0 True False 1580090.7616230613 2385898.0540280095 715857.1394894745 1.0 1.5099753203906003 0.45304811399197703 20.59157599961436 -6.775494327001038 1.5533383938312557 1.2904500604057776 0.4458159348766745 0.7511553299176781 0.21528917710168216 0.25763790277996895 1.2274881423906263 0.10919780823404114 0.25865759759985296 1.6768942401419208e-07 6.775494327001038 -0.8446341255291031 down AGVLAHLEEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGVLAHLEEER 11 0 P35579;P35579-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 15311900.0 2629600.0 6941800.0 5740500.0 False True 3447431.065082622 5906110.49892447 5146528.126764275 1.0 1.7131917614668597 1.4928588939430851 21.717090273185907 -10.0302528553276 4.452493395413394 0.999971815466411 1.6030253277625672 0.9089864330377463 0.08995051672553785 11801963.583803575 6646651.550019306 3079.5252381830414 0.030792455205927556 9.327110987777027e-11 10.0302528553276 0.6030535122961562 AGVLAHLEEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGVLAHLEEER 11 0 P35579;P35579-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 10215500.0 3001600.0 1234100.0 5979800.0 False True 2906315.850992775 1726882.5657464815 4413510.989845305 1.0 0.5941826884220419 1.5185930284685623 21.470760069232007 -6.7873594949426 1.5066910028121847 0.7724088507313529 1.5277459403007576 0.7927130847261457 0.17224623793356147 0.23930876363121886 1.0732307316059198 0.08999489561498097 0.21112830512869651 1.6317007195749736e-07 6.7873594949426 0.7553370895694047 AGVLAHLEEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGVLAHLEEER 11 0 P35579;P35579-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 16410000.0 2629600.0 5268100.0 8512300.0 False True 3601834.182268 5035337.922722943 6501870.056321514 1.0 1.3979927081352466 1.8051552979119714 21.780300334708798 -6.970840676945247 0.2372504046697696 0.8487223757879303 2.366162343358052 0.9999882169773278 0.001128329881127072 0.07603086230945869 0.008047694697115743 0.009925101548119162 0.0398913386618588 1.0694471391805239e-07 6.970840676945247 1.5174399675701216 AGVLAHLEEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGVLAHLEEER 11 0 P35579;P35579-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 5084430.0 3001600.0 1208700.0 874130.0 False True 2495963.393426245 1202188.493191834 1056906.5414795338 1.0 0.4816530948963849 0.42344633108929647 21.251165344666283 -13.999999999999998 0.3086911888962314 5.972338795775451 0.4103743659479922 0.9996691154268864 0.0047142182628178405 17.177056559263026 0.17673284211524248 54.82028107920834 0.020279446248116464 1.0000000000000041e-14 13.999999999999998 -5.561964429827459 AGVLAHLEEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGVLAHLEEER 11 0 P35579;P35579-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 5043200.0 1497700.0 1980200.0 1565300.0 False True 1938802.1740806655 1870000.1292643049 1280431.4613343028 1.0 0.9645131175649806 0.6604239867543233 20.886734174711723 -6.9288404069882 0.7562505743540295 1.0048287612548654 0.5998005459724458 0.9963053636380629 0.009263618269227178 0.09324451848744397 0.08066306867392621 0.008382095534224919 0.02769236923343505 1.1780387955515523e-07 6.9288404069882 -0.4050282152824196 AGVMALANLLQIQR ddPTM_RPMI8226_Bortezomib_1h_R1 2 AGVMALANLLQIQR 14 0 Q9Y224;G3V4C6;H0YJB9 Q9Y224 C14orf166 UPF0568 protein C14orf166 0 16003280.0 2724900.0 7650600.0 5627780.0 False True 3572370.287969134 6509160.301805233 5045471.31107768 1.0 1.8220844361309596 1.4123595552425203 21.768450197635875 -10.191973352118438 4.622995847141821 0.9998939340712988 1.6172219954713454 0.7516007175825458 0.16726948225656926 0.00019568328541628174 3.420262998542119e-05 0.16198751314541535 0.053985993248162716 6.427271532120678e-11 10.191973352118438 0.6173280614000466 AGVMALANLLQIQR ddPTM_RPMI8226_Bortezomib_2h_R1 2 AGVMALANLLQIQR 14 0 Q9Y224;G3V4C6;H0YJB9 Q9Y224 C14orf166 UPF0568 protein C14orf166 0 44227900.0 22414800.0 10088500.0 11724600.0 False True 21703254.44324119 14116890.6608325 8653575.529539509 1.0 0.6504504058481778 0.3987224843246676 24.371408057898925 -7.897282360173071 0.17865655285666457 1.278709821197804 6.5741666428644e-12 0.9999161790010247 0.0022572608358807015 0.11744443532776179 0.027721012473205103 0.07234764312031222 0.09976328076178086 1.2668279593074643e-08 7.897282360173071 -1.27870982119123 down AGVMALANLLQIQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AGVMALANLLQIQR 14 0 Q9Y224;G3V4C6;H0YJB9 Q9Y224 C14orf166 UPF0568 protein C14orf166 0 22755800.0 4194400.0 10922000.0 7639400.0 False True 6363211.451714367 8972883.766024513 6129469.2415320305 1.0 1.4101187480744575 0.9632666285010281 22.601323632964878 -6.66532512373298 1.9537489404611854 1.262815286753527 0.9650959445342756 0.2586277553226418 0.1743980403085732 0.47191752091493344 3.4681492364388813 0.07197524338341219 0.19349356026638426 2.1611000643256262e-07 6.66532512373298 -0.29771934221925134 AGVMALANLLQIQR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AGVMALANLLQIQR 14 0 Q9Y224;G3V4C6;H0YJB9 Q9Y224 C14orf166 UPF0568 protein C14orf166 0 42238500.0 2724900.0 11519900.0 27993700.0 False True 3732369.1676536626 11010912.726784982 21382164.608348783 1.0 2.950113515621753 5.728845043961872 21.831660259158767 -6.966096684261225 0.33870325261634243 0.6940432243387022 8.077079068501245 0.9999339994283676 0.0157639275203569 0.07759076030208509 0.013558523433374074 0.0393831216266758 0.24074105490891332 1.081193225225289e-07 6.966096684261225 7.383035844162543 AGVMALANLLQIQR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AGVMALANLLQIQR 14 0 Q9Y224;G3V4C6;H0YJB9 Q9Y224 C14orf166 UPF0568 protein C14orf166 0 35139200.0 22414800.0 6065300.0 6659100.0 False True 18638899.3440067 6032625.025032219 8051487.021800369 1.0 0.3236577929679092 0.4319722357634443 24.1518133333332 -10.097171661286035 5.437341564469021 1.0000076724354097 0.37781501436995635 0.9777753944624498 0.04421918610482726 4.112775983311006e-06 6.828514750780108e-07 0.042815570059051636 0.014271680947091461 7.995181712180615e-11 10.097171661286035 -0.6221926580654533 AGVMALANLLQIQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGVMALANLLQIQR 14 0 Q9Y224;G3V4C6;H0YJB9 Q9Y224 C14orf166 UPF0568 protein C14orf166 0 17918300.0 4194400.0 8296900.0 5427000.0 False True 5429733.483984746 7835170.221438734 4439341.685722391 1.0 1.4430119350330797 0.8175984509767262 22.372449955057327 -6.71641288233053 1.7720387182075383 1.2705488990411158 0.8187526084580421 0.4956004412534536 0.18650786259996788 0.3623447931728104 2.221599000447707 0.08363142762442151 0.21085173176850475 1.921264320743861e-07 6.71641288233053 -0.4517962905830737 AGVNFSEFTGVWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGVNFSEFTGVWK 13 0 O75340;A0A024QZ42;O75340-2 O75340 PDCD6 Programmed cell death protein 6 0 6117800.0 1403700.0 2911100.0 1803000.0 False True 1840264.2934501367 2476775.2273789216 1616442.8555972436 1.0 1.3458801739479773 0.8783753840959053 20.811481546187064 -6.708537915150983 1.8005443666750391 1.21295756054307 0.8795262711258008 0.4581053310199892 0.14578577595482664 0.3780174357685995 2.388048106412244 0.06445748519219516 0.16403545495188016 1.9564199594183495e-07 6.708537915150983 -0.3334312894172692 AGVNFSEFTGVWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGVNFSEFTGVWK 13 0 O75340;A0A024QZ42;O75340-2 O75340 PDCD6 Programmed cell death protein 6 0 8789100.0 3139500.0 1540100.0 4109500.0 False True 3039838.290975414 2155069.9615154024 3033098.667642615 1.0 0.7089423039091629 0.9977829007046829 21.535563148580856 -10.896584550041368 9.809968218942908 1.01418216282496 0.853362602306931 0.2557565561714702 0.11791867985833299 0.03639519481633051 0.00038367305483764285 0.11361028125649791 0.03805809027484062 1.2688650930909964e-11 10.896584550041368 -0.16081956051802915 AGVNFSEFTGVWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGVNFSEFTGVWK 13 0 O75340;A0A024QZ42;O75340-2 O75340 PDCD6 Programmed cell death protein 6 0 7530100.0 1403700.0 2160600.0 3965800.0 False True 1922685.8235661676 2065137.5478512526 3029159.7182148024 1.0 1.074089964433642 1.5754834622935765 20.874691607709956 -6.933344375119122 0.7188069417075912 0.9932403422348466 1.6877705728887828 0.9971557650124157 0.013632467495744514 0.09093790383660236 0.06944214095756293 0.012676882557489217 0.044562532832858555 1.1658847585894964e-07 6.933344375119122 0.6945302306539363 AGVNTVTTLVENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGVNTVTTLVENK 13 0 P62424;Q5T8U3;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 28729100.0 4130100.0 11400000.0 13199000.0 False True 5414601.095945299 9699164.436851947 11833294.093748223 1.0 1.7912980596327077 2.185441528205935 22.368423624960183 -9.764524864601665 0.175185263200774 1.2764753944885687e-23 2.6511317269027592 0.9996093427383982 0.009742681430264622 1.2457800885090984 0.07589166755192508 0.8850434902671575 0.2766870869577604 1.71978887558587e-10 9.764524864601665 2.6511317269027592 AGVNTVTTLVENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AGVNTVTTLVENK 13 0 P62424;Q5T8U3;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 28069600.0 10444000.0 3345600.0 14280000.0 False True 10112460.936756559 4681515.527073512 10539639.609182755 1.0 0.462945227314277 1.0422428007482822 23.269630793916832 -11.957276143633635 14.534791322169669 0.9081497129645807 0.7773346126281522 0.0 0.2699363557486473 0.0 0.0 0.0 0.07849631874369516 1.103376821040457e-12 11.957276143633635 -0.1308151003364285 AGVNTVTTLVENK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGVNTVTTLVENK 13 0 P62424;Q5T8U3;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 26980600.0 4130100.0 9973500.0 12877000.0 False True 5657109.581755813 9532837.792045953 9835717.810139691 1.0 1.685107501327068 1.738647213386125 22.431633686483075 -11.30143960213627 0.4342571458381774 8.01527455132512e-12 1.7400292992393214 0.9997044366406855 0.0057815363673795 3.4863695302383757 0.21432070727716554 3.3541956668341983 0.012522087495297459 4.995286454363115e-12 11.30143960213627 1.740029299231306 AGVNTVTTLVENK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AGVNTVTTLVENK 13 0 P62424;Q5T8U3;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 16684400.0 10444000.0 3339900.0 2900500.0 False True 8684648.747649139 3321907.295781758 3506981.139603243 1.0 0.38250335647494904 0.4038138146407537 23.05003606935111 -10.129098313535705 4.905967677379731 1.0000323935853443 0.3931585855553904 0.9990759507676918 0.008699958124078033 4616098.315227119 9530620.934323842 1070.0636084076864 0.0029782269603615373 7.428509557668684e-11 10.129098313535705 -0.6068738080299539 AGVNTVTTLVENKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGVNTVTTLVENKK 14 1 P62424;Q5T8U3;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 13628400.0 1818700.0 7239200.0 4570500.0 False True 2384333.3123158533 6159139.578180581 4097588.5033317837 1.0 2.5831705434666503 1.718546850042489 21.185154497411443 -10.06114096073965 5.398215928468211 0.9999901631016798 2.15085869675557 0.7025813789855259 0.35298114473847625 4.1789395326937875e-05 7.26826412317592e-06 0.3417754418064713 0.11392417459093776 8.686784330057495e-11 10.06114096073965 1.1508685336538904 AGVQSGTNALLVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGVQSGTNALLVVK 14 0 Q8N7H5-3;Q8N7H5;Q8N7H5-2 Q8N7H5-3 PAF1 RNA polymerase II-associated factor 1 homolog 0 5502200.0 1561800.0 1844100.0 2096300.0 False True 2047534.9244927128 1568967.468245499 1879394.985129509 1.0 0.7662714073774437 0.9178817721974333 20.965456629230864 -10.634897230782206 5.798160255531299 1.0012064856144447 0.8420765897874385 0.5912837143162804 0.06189467225436339 0.0009724358458033291 6.123302376413796e-05 0.060371567180284566 0.019976419571676313 2.317943091235292e-11 10.634897230782206 -0.1591298958270062 AGVQSGTNALLVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGVQSGTNALLVVK 14 0 Q8N7H5-3;Q8N7H5;Q8N7H5-2 Q8N7H5-3 PAF1 RNA polymerase II-associated factor 1 homolog 0 4845400.0 1561800.0 2049300.0 1234300.0 False True 2139239.666058017 1958755.149871135 942783.7612064476 1.0 0.9156314652114406 0.44070974195412055 21.028666690753756 -6.937199953207279 0.6851166502835525 1.0056764828002516 0.32254152685589343 0.9977736811290128 0.011616077921007432 0.08906756227139113 0.0606025986469914 0.011080497945989153 0.04140496463962058 1.1555800799091986e-07 6.937199953207279 -0.6831349559443581 down AGVSGCFSTFQPTTGHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AGVSGCFSTFQPTTGHR 17 0 Q96EK4 Q96EK4 THAP11 THAP domain-containing protein 11 0 16515900.0 4476800.0 4277700.0 7761400.0 False True 5869128.153392875 3639483.834344003 6958324.780605916 1.0 0.6201063836440612 1.1855806516310927 22.48471477927035 -6.72570028916161 1.7389420159250342 0.770294710508359 1.1849871763953095 0.5392228198070039 0.15975914633412716 0.34435026899567117 2.0379146406650195 0.07286611223622817 0.18169678393079713 1.8806141992008447e-07 6.72570028916161 0.4146924658869505 AGVSGCFSTFQPTTGHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AGVSGCFSTFQPTTGHR 17 0 Q96EK4 Q96EK4 THAP11 THAP domain-containing protein 11 0 10578700.0 4476800.0 2867900.0 3234000.0 False True 6131993.940971024 2741186.695122935 2470195.8063207045 1.0 0.44703023543576065 0.40283728752829456 22.547924840793243 -13.999999999999998 0.3581589137656301 8.152749245314505 0.39737514107856875 0.9997699408999691 0.004120885760240347 21.499491152630707 0.19326592210520124 117.44523367128382 0.012829696399799641 1.0000000000000041e-14 13.999999999999998 -7.755374104235936 AGYSLEK(ub)VFGIQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AGYSLEKVFGIQLK 14 1 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 8026600.0 1625900.0 2539400.0 3861300.0 True False 2104759.601280466 2398080.157687997 3158583.020283743 1.0 1.1393605978702197 1.5006858827783303 21.005224032142596 -6.954676607291309 0.5049024290031334 0.993061263571875 1.6626999556408983 0.9995190033541569 0.004627425389399916 0.08166048861765401 0.02859834104489942 0.005378020803959979 0.029812169535050122 1.1100010579311861e-07 6.954676607291309 0.6696386920690234 AHATLLGLANMETR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHATLLGLANMETR 14 0 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 0 7997600.0 2104200.0 2200900.0 3692500.0 False True 2882179.603866876 2103656.9605969735 2820407.549424616 1.0 0.7298840633576763 0.978567590180923 21.45872880960246 -10.42829361859273 7.929754790615917 1.0000042676536702 0.8542258268876087 0.31419859757606106 0.10152462469211469 7.660070627661305e-06 5.523495334019596e-07 0.09830367150158431 0.03276693172187655 3.72997895443786e-11 10.42829361859273 -0.1457784407660615 AHCFLPAGIVAVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHCFLPAGIVAVLK 14 0 O95905-2;O95905;O95905-3;C9J316;C9JGV1 O95905-2 ECD Protein SGT1 0 3040750.0 860150.0 1120800.0 1059800.0 False True 1127664.97970445 953581.0088441818 950142.062319445 1.0 0.8456243884545445 0.842574771248521 20.104907087496215 AHCFLPAGIVAVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHCFLPAGIVAVLK 14 0 O95905-2;O95905;O95905-3;C9J316;C9JGV1 O95905-2 ECD Protein SGT1 0 2865810.0 860150.0 638060.0 1367600.0 False True 1178170.6996797323 609868.3994177409 1044601.0466061227 1.0 0.5176401005249276 0.8866296258174486 20.168117149019107 -9.793597068497332 6.196008273837195 1.0000000099801523 0.7021348631709267 0.46491455792449365 0.1506393429006812 2.0860745382901884e-08 4.209334698409916e-09 0.14585592310434334 0.04861863886135957 1.6084328393393465e-10 9.793597068497332 -0.2978651468092256 AHDGGIYAISWSPDSTHLLSASGDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHDGGIYAISWSPDSTHLLSASGDK 25 0 O75083;O75083-3 O75083 WDR1 WD repeat-containing protein 1 0 13881500.0 3280600.0 6135900.0 4465000.0 False True 4300898.369375596 5220447.637550867 4003004.6313043237 1.0 1.2138039984210953 0.9307368571663039 22.036206609992888 -6.704643621322806 1.8143847516083507 1.1321467959629365 0.9315003328088066 0.43980980614074516 0.0901734797561255 0.38583190177266063 2.4724630714333133 0.03960279806375594 0.10126537202414454 1.9740419551539539e-07 6.704643621322806 -0.20064646315412993 AHDGGIYAISWSPDSTHLLSASGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHDGGIYAISWSPDSTHLLSASGDK 25 0 O75083;O75083-3 O75083 WDR1 WD repeat-containing protein 1 0 20152800.0 5945900.0 2524200.0 11682700.0 False True 5757150.6591211045 3532126.2235291065 8622650.396512553 1.0 0.6135198525564253 1.4977288084083074 22.45692353602067 -6.787905481168618 1.504750940118389 0.7834082581031143 1.5065905633943815 0.7944553994960757 0.16408735652016493 0.23848436350526878 1.0668160900007337 0.08584401901641249 0.20128766161274633 1.6296506673924563e-07 6.787905481168618 0.7231823052912671 AHDGGIYAISWSPDSTHLLSASGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHDGGIYAISWSPDSTHLLSASGDK 25 0 O75083;O75083-3 O75083 WDR1 WD repeat-containing protein 1 0 22211800.0 3280600.0 9071100.0 9860100.0 False True 4493526.47488151 8670308.807883685 7531347.455133837 1.0 1.9295110101943513 1.676043859368255 22.09941667151578 -10.107646012463432 5.007516829615718 0.9999769657248782 1.8027774347766017 0.9304335740586269 0.10347753105191797 3.153556949747175e-05 5.619544521773095e-06 0.10019508544533802 0.03339722953351057 7.80465998576657e-11 10.107646012463432 0.8028004690517235 AHDGGIYAISWSPDSTHLLSASGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHDGGIYAISWSPDSTHLLSASGDK 25 0 O75083;O75083-3 O75083 WDR1 WD repeat-containing protein 1 0 12622900.0 5945900.0 2478500.0 4198500.0 False True 4944279.298032076 2465147.82855627 5076386.938329329 1.0 0.4985858767196766 1.026719291596216 22.237328811454947 -11.019674636712761 12.995423973369572 1.4276266430918065 0.762652584152854 0.21215806779565016 0.21560956376018936 0.04646363712250093 7.034443174556675e-05 0.003631136863649135 0.06958768747718828 9.557083122417971e-12 11.019674636712761 -0.6649740589389526 AHDQLLDLK(ub)SSLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHDQLLDLKSSLLK 14 1 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 19880000.0 2986900.0 9249400.0 7643700.0 True False 3915854.8251807503 7869425.573878805 6852803.2475477895 1.0 2.009631593917827 1.7500146337093776 21.900895849364314 -10.20634869705289 6.060969418048153 0.9999863825121752 1.8798231138136066 0.9386996031872117 0.10598818018053947 1.9503404909730283e-05 2.5538821105896636e-06 0.10262419774487941 0.03420753806116947 6.218008379163286e-11 10.20634869705289 0.8798367313014314 AHDQLLDLK(ub)SSLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHDQLLDLKSSLLK 14 1 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 21546300.0 6097100.0 8935400.0 6513800.0 True False 5903550.897883803 12503351.817495434 4807640.370188701 1.0 2.117937497917975 0.814364177314378 22.49315154444202 -6.679676993720957 1.9027075671198448 1.7075386212983386 0.819305456112962 0.32270451303924685 0.47384289537385726 0.43929271870483355 3.0744552894110684 0.1998336748955388 0.5273293530536541 2.0908506216919571e-07 6.679676993720957 -0.8882331651853765 AHDQLLDLK(ub)SSLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHDQLLDLKSSLLK 14 1 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 11350100.0 2986900.0 3872000.0 4491200.0 True False 4091237.6479374454 3700922.237008263 3430471.0591674615 1.0 0.904597228389811 0.8384922496244865 21.964105910887206 -6.975042186072155 0.06544730281403925 1.3099873002851827 0.4314538695738222 0.9999999484454374 1.3901671773416292e-05 0.07469786199484774 0.0018851857309441682 0.010183631779070064 0.015052678837672508 1.0591508374232586e-07 6.975042186072155 -0.8785334307113606 AHDQLLDLK(ub)SSLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHDQLLDLKSSLLK 14 1 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 15576500.0 6097100.0 7082100.0 2397300.0 True False 5070008.797327803 7043947.321613217 2898564.346137169 1.0 1.3893363114726343 0.5717079519989955 22.273556819876298 -6.77721599003091 1.5466937624522739 1.2212486963822515 0.5657846315305634 0.7574255015056851 0.16446259559721785 0.2549230617162807 1.2043468206595906 0.08376575816435261 0.1981189377744671 1.6702597283807738e-07 6.77721599003091 -0.6554640648516882 AHDQLLDLK(ub)SSLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHDQLLDLKSSLLK 14 1 Q68DQ2 Q68DQ2 CRYBG3 Very large A-kinase anchor protein 1 13782000.0 5508200.0 5525500.0 2748300.0 True False 7130473.482854458 5218001.067695137 2248137.59993935 1.0 0.7317888608999183 0.3152858790296461 22.765566448053086 -6.968444564354238 0.3643126969723729 1.0342541808861911 9.629044074607285e-20 0.9999066183473886 0.0027222766953767428 0.07752631180760823 0.015242207065252925 0.005529983684440755 0.03524713830425045 1.0753638567654964e-07 6.968444564354238 -1.0342541808861911 down AHEGEIEDLALGPDGK(ub)LVTVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHEGEIEDLALGPDGKLVTVGR 22 1 Q9HCU5;B5MC98 Q9HCU5 PREB Prolactin regulatory element-binding protein 1 37362000.0 11669000.0 13046000.0 12647000.0 True False 15298172.002756748 11099587.652909711 11338409.758590339 1.0 0.725549931776787 0.741161084902637 23.86685593803698 -10.70378542147334 10.206432521568415 1.0002527193575286 0.7333555083411314 0.9974358034736143 0.006373226575797871 3.668344264866823e-05 1.064633904996144e-06 0.006176480933973736 0.0020569500324726345 1.977946673131688e-11 10.70378542147334 -0.2668972110163972 AHEGEIEDLALGPDGK(ub)LVTVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHEGEIEDLALGPDGKLVTVGR 22 1 Q9HCU5;B5MC98 Q9HCU5 PREB Prolactin regulatory element-binding protein 1 54784000.0 17555000.0 12438000.0 24791000.0 True False 16997726.134121187 17404558.26331315 18297493.385941867 1.0 1.0239345031201137 1.0764671251651436 24.01883842737211 -6.958187185284435 0.46027822083309794 0.9984730138517998 1.1040472671149097 0.9996968876029504 0.0005559974577949553 0.08035526178105169 0.023573640460611226 0.0007137899538458668 0.004339585988676842 1.1010646373350088e-07 6.958187185284435 0.10557425326310999 AHEGEIEDLALGPDGK(ub)LVTVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AHEGEIEDLALGPDGKLVTVGR 22 1 Q9HCU5;B5MC98 Q9HCU5 PREB Prolactin regulatory element-binding protein 1 70249700.0 8905700.0 25058000.0 36286000.0 True False 13510597.99388055 20586204.12095237 29114056.19528121 1.0 1.523707842560087 2.1549050758869477 23.687588195552642 -6.968637608857048 0.2888778331756468 0.8750012452147711 2.823082636206806 0.9999697204312371 0.002598187793294048 0.07674727893834125 0.010604438967340465 0.011094316608037641 0.057314522687463454 1.074885962251876e-07 6.968637608857048 1.9480813909920351 AHEGEIEDLALGPDGK(ub)LVTVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHEGEIEDLALGPDGKLVTVGR 22 1 Q9HCU5;B5MC98 Q9HCU5 PREB Prolactin regulatory element-binding protein 1 38202000.0 11669000.0 10102000.0 16431000.0 True False 15983344.64286786 9655660.23715328 12550336.207067255 1.0 0.6041076165783524 0.7852133885298849 23.930065999559872 -10.056407017721758 4.717642737150879 1.0000098382873246 0.6946605025535691 0.7912320800285881 0.07393612181921014 102487592.07661541 0.28190065318822366 12018.76825362645 0.0253103010802136 8.781990890507682e-11 10.056407017721758 -0.30534933573375544 AHEGEIEDLALGPDGK(ub)LVTVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHEGEIEDLALGPDGKLVTVGR 22 1 Q9HCU5;B5MC98 Q9HCU5 PREB Prolactin regulatory element-binding protein 1 41133000.0 17555000.0 10070000.0 13508000.0 True False 14597760.31836278 10015750.91126149 16332460.346064702 1.0 0.686115588475754 1.1188332997576218 23.799243702806386 -6.712145705945294 1.7874561842440442 0.8074541417877865 1.1178859757694877 0.4752953085899524 0.1322259732851818 0.3707986976362092 2.310652235421104 0.05883765645034672 0.14909326009809226 1.9402348189469188e-07 6.712145705945294 0.31043183398170116 AHEGEIEDLALGPDGK(ub)LVTVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHEGEIEDLALGPDGKLVTVGR 22 1 Q9HCU5;B5MC98 Q9HCU5 PREB Prolactin regulatory element-binding protein 1 60857700.0 8905700.0 18172000.0 33780000.0 True False 11528604.207591765 17160712.225528184 27632386.612069756 1.0 1.4885333832718093 2.3968544773072704 23.45871451764509 -6.961446220990378 0.4145483640735274 0.9574146796206856 2.961932917089518 0.9998201325427741 0.007762335746840502 0.07918849107234956 0.019251919690376852 0.011715366703155405 0.07573017110537798 1.0928329451291853e-07 6.961446220990378 2.0045182374688326 AHEILPNLVCCSAK(ub)NLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHEILPNLVCCSAKNLR 17 1 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 10541200.0 2863100.0 3218600.0 4459500.0 True False 3921665.4423682336 3076391.6095131147 3406257.9462854676 1.0 0.7844604938190058 0.8685743331099862 21.903035033660014 -10.37395830646507 5.0151232055043256 1.0001257707537787 0.8265174134644706 0.8501138504473531 0.03433933109498292 4.832462918152432e-05 6.032387359095869e-06 0.03327294862757398 0.011082971454218344 4.227091936312224e-11 10.37395830646507 -0.17360835728930812 AHEILPNLVCCSAK(ub)NLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHEILPNLVCCSAKNLR 17 1 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 29128300.0 5532900.0 6697300.0 16898100.0 True False 7162448.1197642535 6324589.367600154 13822819.189147873 1.0 0.8830206183480632 1.9299014747492287 22.77202135326284 -6.879158906770639 1.0845329352116233 0.9282827249740873 2.0028912915910535 0.9729982884439324 0.0769639968123294 0.1283752447540382 0.2768399442194194 0.054708754461802095 0.13201587847729804 1.3208122653587312e-07 6.879158906770639 1.0746085666169662 AHFNLDESGVLSLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHFNLDESGVLSLDR 15 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 12339800.0 3871000.0 1755600.0 6713200.0 False True 3748117.2238782677 2456620.2353330557 4954811.528316926 1.0 0.6554278024397356 1.3219467888440433 21.8377346438963 -6.7661861195319455 1.5888988322847049 0.8013996751039189 1.3251801143332955 0.7157989672594365 0.14508854194254137 0.27265079892705757 1.3578099721928405 0.07199926848424118 0.17200548172806238 1.7132229380885729e-07 6.7661861195319455 0.5237804392293767 AHFNLDESGVLSLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHFNLDESGVLSLDR 15 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 6949900.0 3871000.0 1578800.0 1500100.0 False True 3218908.014376657 1570294.6910327356 1813763.9743212643 1.0 0.4878345960864072 0.5634718252961635 21.618139919330577 -10.674388235996279 6.705376633131455 1.0031099001911767 0.5256532106913654 0.981287287602451 0.03087876952030635 0.0014416771554586585 7.000748151583169e-05 0.030024942247878942 0.009966080008626966 2.116468280082075e-11 10.674388235996279 -0.47745668949981135 AHGFTFTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHGFTFTR 8 0 P08559;P08559-4;P08559-3;P08559-2;Q5JPU0;Q5JPT9;Q5JPU1 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 0 41625000.0 12806000.0 9608000.0 19211000.0 False True 16788790.013480406 8174523.8516906705 17223230.004924387 1.0 0.4869036925905328 1.0258767898755747 24.000994921618403 -10.983013253325614 13.105009078857488 1.1459093800900264 0.756390241233951 0.21407851560795899 0.22003484557263173 0.07414618927501848 9.610840976749703e-05 0.01684039764110641 0.07101594104067696 1.0398884311631838e-11 10.983013253325614 -0.38951913885607536 AHGFTFTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHGFTFTR 8 0 P08559;P08559-4;P08559-3;P08559-2;Q5JPU0;Q5JPT9;Q5JPU1 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 0 31492600.0 12806000.0 7643600.0 11043000.0 False True 17540724.269137524 7305880.477994922 8434870.837724049 1.0 0.41650962445430145 0.4808735778695865 24.064204983141295 -10.203305915588874 5.405847414210904 1.0000272011930447 0.4486916011644165 0.9898809335048825 0.026276473949562278 8.614746315936416e-06 1.2695634909941416e-06 0.025443338807035656 0.008480695500268974 6.261726353682377e-11 10.203305915588874 -0.5513356000286282 AHGFTFTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHGFTFTR 8 0 P08559;P08559-4;P08559-3;P08559-2;Q5JPU0;Q5JPT9;Q5JPU1 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 0 17671300.0 6173000.0 7933500.0 3564800.0 False True 5133123.0102679245 7890760.660823555 4310183.198227084 1.0 1.5372241508803615 0.8396804809869759 22.29140540306126 -6.700952989649138 1.8271011992624537 1.3332679894171027 0.8416898982979062 0.4223239138155327 0.22672764472724996 0.39351510736730916 2.554536412400419 0.09896497738676421 0.25424776543849453 1.9908888317487145e-07 6.700952989649138 -0.4915780911191965 AHGGYSVFAGVGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHGGYSVFAGVGER 14 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 273783000.0 93808000.0 100850000.0 79125000.0 False True 122983196.43796436 85803573.11022112 70937904.0205945 1.0 0.6976853390983578 0.5768097274685591 26.873885968389434 -13.99999999952088 0.1264265450815786 2.436748256229919 0.39959059643036016 0.9996620800106286 0.0032717481672435316 11.94370771054148 0.1102032883420219 4.27898165813024 0.15742763981012764 1.0000000011032163e-14 13.99999999952088 -2.037157659799559 AHGGYSVFAGVGER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHGGYSVFAGVGER 14 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 193308000.0 55342000.0 36976000.0 100990000.0 False True 53585198.502679184 51740709.62729263 74537689.3649416 1.0 0.9655783886795841 1.3910126573705763 25.675331213481208 -6.887298603712234 1.0382087758026382 0.9756387895107967 1.4257273244852136 0.9791129811777282 0.027885907251269423 0.12136322399042324 0.23485900764926365 0.020534316373417596 0.05072001342645331 1.2962876883558345e-07 6.887298603712234 0.4500885349744168 AHGGYSVFAGVGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 AHGGYSVFAGVGER 14 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 298566000.0 54172000.0 144870000.0 99524000.0 False True 82182884.50368845 119016816.62552358 79853037.77708124 1.0 1.4481946860867603 0.9716504629804926 26.29233463217312 -6.660041881947636 1.9732207559369586 1.2884944382446004 0.9736562434449281 0.23562400977522824 0.19083049919196568 0.4843177945265868 3.6252640960819953 0.07814179797566069 0.21148237009246937 2.187550653505314e-07 6.660041881947636 -0.31483819479967234 AHGGYSVFAGVGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHGGYSVFAGVGER 14 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 250801000.0 93808000.0 86104000.0 70889000.0 False True 128491352.66587962 82299640.57214871 54146478.20478312 1.0 0.6405072315345238 0.4214017292321766 26.937096029912325 -8.999529832593515 0.13832362806105863 1.528404314772622 7.773190880690728e-13 0.9998843217697211 0.002565347341162016 0.4717085553603816 0.04447024186699314 0.27957920584429924 0.17865906017472183 1.0010831866847932e-09 8.999529832593515 -1.5284043147718447 AHGGYSVFAGVGER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHGGYSVFAGVGER 14 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 136951000.0 55342000.0 37325000.0 44284000.0 False True 46019325.0662963 37123922.81656759 53543579.65391839 1.0 0.8067028962959838 1.1635020630307487 25.455736488915484 -6.759581811565631 1.6141212695144664 0.8876636296858283 1.1647752919502035 0.6892323615494225 0.08129620264580158 0.28361874550792465 1.4562923130032837 0.039741300944931834 0.09554115649023491 1.7394749881941655e-07 6.759581811565631 0.2771116622643751 AHGGYSVFAGVGER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHGGYSVFAGVGER 14 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 342375900.0 54172000.0 188033900.0 100170000.0 False True 70126721.88976297 177569648.16991776 81940087.83099532 1.0 2.5321253209162085 1.1684574099984681 26.06346095426557 -6.618180889113543 2.1229930471246905 2.0179192568358193 1.173578644384652 0.07667355571313006 0.6591774947453327 0.5904793054917344 5.054370682153356 0.2553231644802342 0.7312264859013098 2.408901881777244e-07 6.618180889113543 -0.8443406124511672 AHIAQLCEK(ub)AGLLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHIAQLCEKAGLLQR 15 1 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 8532400.0 2597300.0 3036000.0 2899100.0 True False 2514850.1331901397 4248290.632530841 2139738.7388642672 1.0 1.6892818289500997 0.8508414519914013 21.262040997766274 -6.688278703864242 1.8724457891129214 1.432837168000979 0.853796242542967 0.3623563976520475 0.29162173128684304 0.42041618125027286 2.8564457976543824 0.1246528489484092 0.32532106738302075 2.0498462895893016e-07 6.688278703864242 -0.579040925458012 AHIAQLCEK(ub)AGLLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AHIAQLCEKAGLLQR 15 1 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 71270500.0 6861900.0 26684600.0 37724000.0 True False 10410003.972086303 21922524.64226856 30267834.864983454 1.0 2.105909344612382 2.9075718843282417 23.311467283329954 -7.769585687371103 0.163801946493806 2.2433005863540102e-18 4.389552615085349 0.9999533917970099 0.005339120773303904 0.13359195826566955 0.022349343964792382 0.21636286642867056 0.3187095495965818 1.6998645330940373e-08 7.769585687371103 4.389552615085349 AHIISDQK(ub)VQNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHIISDQKVQNK 12 1 A0A669KAX4;K4DI93;Q13620-3;Q13620-1;Q13620 A0A669KAX4 CUL4B Cullin-4B 1 5172500.0 1178100.0 1891500.0 2102900.0 True False 1525073.6738228158 1786236.3622378712 1720193.7775761222 1.0 1.1712459488992513 1.127941428078166 20.540447507928523 -10.13513878996272 4.585367475562591 0.9999838114926884 1.1495936884916094 0.9408670554144343 0.017678996604461417 2.9260853267407046e-06 5.519159951870046e-07 0.01711946688149824 0.005705871617499833 7.325903776435183e-11 10.13513878996272 0.14960987699892092 AHIQSLFSFITGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHIQSLFSFITGTK 14 0 A0A5F9ZI68;E7EN32;A0A5F9ZHS3;O00255-3;O00255-2;E7ENS2 A0A5F9ZI68 MEN1 Menin 0 2054420.0 416840.0 1020900.0 616680.0 False True 546481.2766843025 868585.6994370326 552871.8692122623 1.0 1.5894152947143092 1.011694074070998 19.059812542159356 -10.29558627089468 3.8248930117459694 0.9993936414060226 1.3005546844532736 0.26517519801545264 0.23585370089727822 30904397.86052437 27729582.66319963 138047.60636709371 0.08073899386975508 5.063067636818085e-11 10.29558627089468 0.301161043047251 AHIQSLFSFITGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHIQSLFSFITGTK 14 0 A0A5F9ZI68;E7EN32;A0A5F9ZHS3;O00255-3;O00255-2;E7ENS2 A0A5F9ZI68 MEN1 Menin 0 3850600.0 0.0 0.0 3850600.0 False True 0.0 0.0 2842012.344476129 0.0 AHIQSLFSFITGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHIQSLFSFITGTK 14 0 A0A5F9ZI68;E7EN32;A0A5F9ZHS3;O00255-3;O00255-2;E7ENS2 A0A5F9ZI68 MEN1 Menin 0 7024340.0 416840.0 3251300.0 3356200.0 False True 570957.0126774395 3107646.815388682 2563534.6831087046 1.0 5.442873537564093 4.489890878276971 19.123022603682248 -10.402511625064191 5.707473300625901 0.9984574921920225 4.966382207920272 0.9585012678172848 0.38905354149570703 0.007636406551740229 0.0007994188907431108 0.3766894768416384 0.1255664905829859 3.9581146973143485e-11 10.402511625064191 3.96792471572825 AHIVFDFHQAADGIQEQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHIVFDFHQAADGIQEQQR 19 0 P30520 P30520 ADSS Adenylosuccinate synthetase isozyme 2 0 16353600.0 4415100.0 7183200.0 4755300.0 False True 5788238.855889222 6111494.5598943 4263267.172058553 1.0 1.0558469876681373 0.7365396069861403 22.464693026283094 -6.8617698614732445 1.176850519100672 1.0304512281721987 0.720552888402339 0.9557506764417131 0.029289649565566917 0.14498433510400496 0.380571238191875 0.019398096765398658 0.04537221926031587 1.3747702914163382e-07 6.8617698614732445 -0.3098983397698597 AHIVFDFHQAADGIQEQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHIVFDFHQAADGIQEQQR 19 0 P30520 P30520 ADSS Adenylosuccinate synthetase isozyme 2 0 15045700.0 3751700.0 3076200.0 8217800.0 False True 3632604.3370767552 4304542.702171075 6065311.65128446 1.0 1.1849742781607326 1.6696868385521346 21.792572805426325 -6.9544456492846844 0.5076982136368776 0.9909076815798002 1.8849352522889542 0.9995055571588413 0.006279001638122154 0.08174819151928178 0.02894317234087754 0.007261251389098239 0.03999870007496541 1.1105915139963919e-07 6.9544456492846844 0.894027570709154 AHIVFDFHQAADGIQEQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHIVFDFHQAADGIQEQQR 19 0 P30520 P30520 ADSS Adenylosuccinate synthetase isozyme 2 0 18624800.0 4415100.0 4998700.0 9211000.0 False True 6047481.7835912155 4777840.905509604 7035551.506499693 1.0 0.7900546171918104 1.163385316114458 22.527903087805985 -6.754125087929605 1.6344751441914345 0.8771604122110098 1.1643702071113804 0.6664955531975534 0.08824534668575652 0.2929417183845301 1.5409179825839117 0.04262689785467906 0.10304662554986699 1.7614686252787593e-07 6.754125087929605 0.2872097949003706 AHIVFDFHQAADGIQEQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHIVFDFHQAADGIQEQQR 19 0 P30520 P30520 ADSS Adenylosuccinate synthetase isozyme 2 0 10984400.0 3751700.0 3746300.0 3486400.0 False True 3119704.7784905513 3726117.938317671 4215390.120707724 1.0 1.1943815850807937 1.3512144321384516 21.5729780808606 -6.973562743620801 0.15042902380849937 0.8187785184586936 1.730943871858564 0.999998524751469 0.00017438824262851028 0.07516272584675594 0.004599908631976673 0.007969854107295825 0.019530555944411946 1.0627650318353478e-07 6.973562743620801 0.9121653533998703 AHIVFDFHQAADGIQEQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHIVFDFHQAADGIQEQQR 19 0 P30520 P30520 ADSS Adenylosuccinate synthetase isozyme 2 0 40053000.0 10430000.0 17387000.0 12236000.0 False True 13501840.60603682 16419398.165598633 10009173.551962255 1.0 1.2160859133722361 0.7413191907692233 23.68665275683546 -6.782944662558291 1.5241197504380017 1.1218890176129719 0.7371880520081053 0.7777198056822698 0.0915033241668556 0.24604937478674047 1.1290497718391672 0.04727438198244206 0.11128935150701691 1.6483724123868204e-07 6.782944662558291 -0.38470096560486655 AHK(ub)EKPNQPAPRPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHKEKPNQPAPRPPR 15 3 Q9BZV1;K7EP32;K7EJ02 Q9BZV1 UBXN6 UBX domain-containing protein 6 1 1511300.0 147200.0 506970.0 857130.0 True False 142527.21657320648 709405.7648136246 632621.9396511778 1.0 4.977335430172043 4.438604463493773 17.120877912773643 -10.147907762428712 4.554382844176603 0.999514716804892 4.707969946907885 0.9844148534157423 0.2199359964216413 38455159.78296114 188.4108193361601 196780.23793496963 0.07528994149152317 7.113645806750879e-11 10.147907762428712 3.708455230102993 AHK(ub)EKPNQPAPRPPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHKEKPNQPAPRPPR 15 3 Q9BZV1;K7EP32;K7EJ02 Q9BZV1 UBXN6 UBX domain-containing protein 6 1 907720.0 147200.0 544810.0 215710.0 True False 122403.3220656794 541875.0003936824 260813.9636696487 1.0 4.426963184078632 2.1307752050201763 16.90128318820792 -9.578796163738447 10.345684962361485 0.9999591832340317 3.2788691947093334 0.5677163846874449 0.9374148173304933 0.0 0.0 0.9076479938684268 0.30254933128947553 2.6375690392742653e-10 9.578796163738447 2.278910011475302 AHK(ub)STVWQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHKSTVWQVR 10 1 H7C389;Q8ND98;Q96MX6-2;Q96MX6 H7C389 WDR92;DKFZp434B156 WD repeat-containing protein 92 1 2599170.0 649510.0 1235000.0 714660.0 True False 540096.3431717345 1228346.809871693 864092.1017855046 1.0 2.274310547370463 1.599885118108917 19.042857254709933 -10.029901882820091 4.978955043097671 0.999987774417038 1.9370978327467239 0.7202163891890854 0.27533302857291414 4.2355739126062936e-05 8.252493897900805e-06 0.26659399236546766 0.08886335285579165 9.334651683728507e-11 10.029901882820091 0.9371100583296859 AHLEK(ub)ESIAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHLEKESIAQR 11 1 Q9Y673-2;Q9Y673 Q9Y673-2 ALG5 Dolichyl-phosphate beta-glucosyltransferase 1 5843420.0 532520.0 2346300.0 2964600.0 True False 689357.6375385168 2215726.3424365395 2425073.219364768 1.0 3.2141898802314195 3.5178738688149673 19.394893119253222 -10.114942232557738 0.4527128665884395 4.667423478306294e-15 3.5253966223794913 0.9991687182754794 0.032356012057925654 1.4345915738828636 0.207155352011557 1.9469788306177354 0.06773665290413929 7.674635663180671e-11 10.114942232557738 3.5253966223794864 AHLGTALK(ub)ANPFGGASHAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHLGTALKANPFGGASHAK 19 1 P62266;D6RD47;D6RIX0;D6R9I7;D6RDJ2 P62266 RPS23 40S ribosomal protein S23 1 18367800.0 4808700.0 4906500.0 8652600.0 True False 6304252.267517047 4174469.3253872087 7757311.953599959 1.0 0.6621672401811006 1.2304888231662094 22.587893835370686 -6.745672317428672 1.6657931611169474 0.8003200149332317 1.2312593340960944 0.6301383889874039 0.14194012337207285 0.3076708554812374 1.6783136868360187 0.067350359684422 0.16426267631864766 1.796088294867343e-07 6.745672317428672 0.43093931916286277 AHLGTALK(ub)ANPFGGASHAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHLGTALKANPFGGASHAK 19 1 P62266;D6RD47;D6RIX0;D6R9I7;D6RDJ2 P62266 RPS23 40S ribosomal protein S23 1 60238800.0 3691700.0 5671100.0 50876000.0 True False 3574509.004234415 7935599.804395811 37550049.352715805 1.0 2.2200531023967724 10.50495307417983 21.76931365574556 -6.933275356465337 0.719396393887334 0.88803626983692 12.356952822602576 0.9971437682413108 0.22567082211307357 0.09097240898050822 0.0696070523089459 0.20975994548859883 0.7366055422151511 1.1660700572617633e-07 6.933275356465337 11.468916552765656 AHLGTALK(ub)ANPFGGASHAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHLGTALKANPFGGASHAK 19 1 P62266;D6RD47;D6RIX0;D6R9I7;D6RDJ2 P62266 RPS23 40S ribosomal protein S23 1 18879400.0 4808700.0 2967700.0 11103000.0 True False 6586606.340231273 2836577.201128465 8480700.073462833 1.0 0.4306583777145645 1.2875674718348284 22.651103896893577 -6.72760708736712 1.7320818643822635 0.6564534604296512 1.2868245131685934 0.548034569555704 0.23938694516656656 0.3407657462726925 2.0017467619935054 0.10957691342299274 0.2726342500675897 1.8723753399464768e-07 6.72760708736712 0.6303710527389421 AHLGTALK(ub)ANPFGGASHAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHLGTALKANPFGGASHAK 19 1 P62266;D6RD47;D6RIX0;D6R9I7;D6RDJ2 P62266 RPS23 40S ribosomal protein S23 1 24815700.0 3691700.0 10267000.0 10857000.0 True False 3069812.1200398663 10211689.633160064 13127148.502903784 1.0 3.326486844747831 4.2762058359237 21.549718931179836 -9.197134728153959 0.30783225909661716 4.601109439264961e-19 4.655122036968159 0.9985787301968616 0.05188647074235235 0.6133105474846463 0.11415713387333305 1.0071445200871445 0.3183891556894645 6.351338681277841e-10 9.197134728153959 4.655122036968159 AHLILFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHLILFK 7 0 F5GZY1;Q9H993 F5GZY1 ARMT1 Protein-glutamate O-methyltransferase 0 16080000.0 3565600.0 3506300.0 9008100.0 False True 4674536.129319519 2983173.707450355 8076028.223796752 1.0 0.6381753450870474 1.7276640933722756 22.15639177771825 -6.817181732893916 1.3839860976089455 0.8044046334807003 1.7500484190526466 0.8777859726823778 0.1583869841012131 0.19716964011830607 0.742828061633624 0.08994824141576278 0.20749191571871778 1.5234151390286548e-07 6.817181732893916 0.9456437855719463 AHLILFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHLILFK 7 0 F5GZY1;Q9H993 F5GZY1 ARMT1 Protein-glutamate O-methyltransferase 0 11051100.0 3556400.0 1720800.0 5773900.0 False True 3443504.02867494 2407924.413853454 4261542.376712907 1.0 0.6992657461126952 1.2375598637974436 21.71544593421391 -6.755097437846361 1.6310304615933873 0.824255232502088 1.2390569281769712 0.6705989589599255 0.12641574441391532 0.29123096498036516 1.5257596920081213 0.06118984020655514 0.14776327398988717 1.757529252334136e-07 6.755097437846361 0.41480169567488323 AHLILFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHLILFK 7 0 F5GZY1;Q9H993 F5GZY1 ARMT1 Protein-glutamate O-methyltransferase 0 14037600.0 3565600.0 4214100.0 6257900.0 False True 4883898.676716912 4027907.1278348425 4779912.9054960925 1.0 0.8247319189968352 0.9787084503377287 22.219601839241143 -10.242550473405236 6.279147260993506 1.0000017231663696 0.9017201846781744 0.35199510239968235 0.06286065569147552 1.516385691274657e-06 1.8301042833476858e-07 0.060865635619155374 0.02028818938539688 5.7207046515370754e-11 10.242550473405236 -0.09828153848819521 AHLILFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHLILFK 7 0 F5GZY1;Q9H993 F5GZY1 ARMT1 Protein-glutamate O-methyltransferase 0 7336900.0 3556400.0 2542700.0 1237800.0 False True 2957304.175233573 2529001.9704135656 1496618.257059436 1.0 0.85517140630751 0.5060751848230933 21.495851209648187 -6.956238828033811 0.48554665962741506 1.007957208178132 0.33859738779235826 0.9996042756673742 0.004124020910818465 0.08107305493752344 0.02631137576632745 0.00497886384371014 0.02879343213043266 1.1060153946551341e-07 6.956238828033811 -0.6693598203857738 AHLLLQAHLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AHLLLQAHLSR 11 0 Q8N3C0 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 0 11387300.0 2835000.0 3272900.0 5279400.0 False True 4300902.266262206 2688825.423715583 4235924.275956774 1.0 0.6251770575694495 0.984892009563867 22.036207917165473 -10.67419500861244 9.522789984574661 1.0001539519461458 0.8050345340161015 0.2814466856201798 0.1468530142060115 0.0004803659701864607 1.6434901109322758e-05 0.14230047941326765 0.047396606530020306 2.1174101539417414e-11 10.67419500861244 -0.19511941793004428 AHLMEIQVNGGTVAEK ddPTM_RPMI8226_Bortezomib_1h_R1 2 AHLMEIQVNGGTVAEK 16 0 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2 P39023 RPL3 60S ribosomal protein L3 0 99580000.0 22981400.0 29366600.0 47232000.0 False True 30128837.95219421 24985217.75011024 42344885.72133614 1.0 0.8292791706654795 1.4054603031330077 24.844641694497493 -6.827347171323303 1.339892738049204 0.9085996553601378 1.4201228679133693 0.900428672627879 0.0762507236745286 0.18411029577885268 0.6473956074841473 0.04469564901515207 0.102866233851993 1.4881709708485198e-07 6.827347171323303 0.5115232125532315 AHLMEIQVNGGTVAEK ddPTM_RPMI8226_Bortezomib_2h_R1 2 AHLMEIQVNGGTVAEK 16 0 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2 P39023 RPL3 60S ribosomal protein L3 0 87403200.0 53342700.0 1744000.0 32316500.0 False True 51649365.18681776 2440388.2948398544 23851839.175781127 1.0 0.04724914403135208 0.4618031429720017 25.6222472815021 -10.735371642142802 6.602657681509167 1.0133408025897594 0.254526143501677 0.8117338282020143 0.16924096137247827 0.03249251365386346 0.0013022684300899854 0.16020142646793556 0.05462228540764509 1.8391974573420467e-11 10.735371642142802 -0.7588146590880824 AHLMEIQVNGGTVAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AHLMEIQVNGGTVAEK 16 0 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2 P39023 RPL3 60S ribosomal protein L3 0 29670200.0 7146100.0 14201000.0 8323100.0 False True 10841156.149889374 11666720.597080579 6678035.63685568 1.0 1.0761509598955117 0.615989249165443 23.370015284627375 -6.8643917414936215 1.1632539663273105 1.0419101816527052 0.591752392662625 0.9587636981386534 0.040895185505464705 0.14235105900201553 0.36354766819985984 0.02736530930341562 0.0642329772775146 1.3664956656570198e-07 6.8643917414936215 -0.4501577889900802 AHLMEIQVNGGTVAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AHLMEIQVNGGTVAEK 16 0 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2 P39023 RPL3 60S ribosomal protein L3 0 78228400.0 22981400.0 3639300.0 51607700.0 False True 31478244.628983095 3478503.6924442556 39419024.15394468 1.0 0.11050500856840913 1.2522624631250956 24.907851756020385 -6.698857124731624 1.8355250187534804 0.4470265975728555 1.2487300311060334 0.4119288974494474 0.37554712129087753 0.3978848675221634 2.605527702005777 0.16329659470988106 0.420458797427957 2.0005198973503688e-07 6.698857124731624 0.8017034335331779 AHLMEIQVNGGTVAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AHLMEIQVNGGTVAEK 16 0 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2 P39023 RPL3 60S ribosomal protein L3 0 62207300.0 53342700.0 2022300.0 6842300.0 False True 44356818.5322888 2011405.4685048806 8272993.29477928 1.0 0.04534602649738533 0.18651006921871763 25.402652556936378 -10.166547586673083 5.075871539253552 1.0000519983327063 0.11592804913326893 0.9812367517843754 0.057629979119585104 323038088.3449491 21.251715644418027 196322.87093477906 0.019728274719666112 6.814788993815357e-11 10.166547586673083 -0.8841239491994374 AHLMEIQVNGGTVAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHLMEIQVNGGTVAEK 16 0 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2 P39023 RPL3 60S ribosomal protein L3 0 17866500.0 7146100.0 7869600.0 2850800.0 False True 9250767.32069029 7431649.842065626 2331983.6516781626 1.0 0.8033549633708741 0.25208542933108286 23.141141606719824 -6.952964079390795 0.5252980178152132 1.0089984635343128 0.0216169925932579 0.999413823633701 0.007664475827170839 0.0823169394030881 0.031202369939898115 0.008611430427103777 0.04556087271241834 1.1143867009930674e-07 6.952964079390795 -0.9873814709410549 down AHLVAVFNEYQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHLVAVFNEYQR 12 0 P50995-2;P50995;H0Y6E1 P50995-2 ANXA11 Annexin A11 0 32056300.0 12112000.0 11118000.0 8826300.0 False True 15878949.292774856 9459237.737624556 7913039.143848016 1.0 0.595709298091193 0.49833518565668317 23.920612116978692 -13.999999999999579 0.19996229903735363 3.247073914016203 0.4350725016261948 0.9994869276157806 0.0049199184250179676 12.53015750563747 0.14179108172563923 11.012054611558405 0.06202020365748315 1.0000000000009694e-14 13.999999999999579 -2.8120014123900083 AHLVAVFNEYQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHLVAVFNEYQR 12 0 P50995-2;P50995;H0Y6E1 P50995-2 ANXA11 Annexin A11 0 34896600.0 10228000.0 6079600.0 18589000.0 False True 9903317.738524146 8507215.98469516 13719983.241953647 1.0 0.8590268644619857 1.3853926132837866 23.23948049684564 -6.835435842255502 1.3034640211810002 0.9249081398883753 1.401193954713702 0.9163100424678945 0.06436068352210016 0.1741989806132197 0.5768852382249084 0.038744840817162195 0.08917888137775118 1.4607105223203127e-07 6.835435842255502 0.4762858148253267 AHLVAVFNEYQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AHLVAVFNEYQR 12 0 P50995-2;P50995;H0Y6E1 P50995-2 ANXA11 Annexin A11 0 51876800.0 8533800.0 24661000.0 18682000.0 False True 12946398.504348647 20260051.872727543 14989494.511388503 1.0 1.564917985949704 1.1578119201532062 23.626047481617228 -10.377167707990974 6.302236530966025 0.9999570750688854 1.361364953051455 0.5123253416442479 0.16620035539888933 0.00010025137306949564 9.907449502898113e-06 0.16094185304245845 0.053640934049471005 4.1959692034923255e-11 10.377167707990974 0.3614078779825697 AHLVAVFNEYQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHLVAVFNEYQR 12 0 P50995-2;P50995;H0Y6E1 P50995-2 ANXA11 Annexin A11 0 41133000.0 12112000.0 15324000.0 13697000.0 False True 16590133.714492721 14646935.01030852 10462050.69856979 1.0 0.8828702204800994 0.6306188291556931 23.983822178501583 -6.958572072242675 0.4551108128703563 1.0077228296016696 0.4956804102506651 0.9997135192346069 0.002608685652394782 0.08021518469584314 0.023046135069596914 0.0033983238508446235 0.02085060070431052 1.1000892676136017e-07 6.958572072242675 -0.5120424193510045 AHLVAVFNEYQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHLVAVFNEYQR 12 0 P50995-2;P50995;H0Y6E1 P50995-2 ANXA11 Annexin A11 0 16399400.0 10228000.0 6171400.0 0.0 False True 8505035.177226683 6138153.443273005 0.0 1.0 0.7217081781988033 0.0 23.019885772279917 -7.386329733236606 0.7682418932836231 0.9900931293375562 4.500569245201192e-18 0.9875503783293106 0.047020494907313484 0.1120553806670229 0.13864640779516416 0.040620258240825644 0.07264806849038082 4.108376787414778e-08 7.386329733236606 -0.9900931293375562 down AHLVAVFNEYQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHLVAVFNEYQR 12 0 P50995-2;P50995;H0Y6E1 P50995-2 ANXA11 Annexin A11 0 54964800.0 8533800.0 24525000.0 21906000.0 False True 11047172.326346781 23160162.190792345 17919332.77454112 1.0 2.0964787645755174 1.622074160263137 23.397173803709677 -10.292355653979595 5.164884921509122 0.9998097908947652 1.8592764624194729 0.8139286323763092 0.19367486869922215 0.00042428808116886323 5.813218996855066e-05 0.18756541868500606 0.06250829508750998 5.1008710654241844e-11 10.292355653979595 0.8594666715247077 AHMLIDMHFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AHMLIDMHFR 10 0 A8MQB8;Q06787-2;A0A087WXI3;G3V0J0;Q06787-11;Q06787-8;Q06787-9;R9WNI0;A0A087WY29;Q8IXW7;Q06787-6;Q06787-4;Q06787-7;Q06787-10;Q06787-5;Q06787-3;Q06787 A8MQB8;Q06787-6 FMR1 Fragile X mental retardation protein 1 0 12958800.0 2359200.0 4905500.0 5694100.0 False True 3579078.8806228563 4030075.198153562 4568658.639187311 1.0 1.1260090466215766 1.2764900667381327 21.771156909510257 -6.968768663972835 0.2860705549547757 0.9691803006678488 1.437942744759137 0.9999711195420793 0.0006073690037070424 0.07670428007749125 0.010453288749436922 0.0026859101730474424 0.013709554922068707 1.0745616476278229e-07 6.968768663972835 0.4687624440912883 AHMLIDMHFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHMLIDMHFR 10 0 A8MQB8;Q06787-2;A0A087WXI3;G3V0J0;Q06787-11;Q06787-8;Q06787-9;R9WNI0;A0A087WY29;Q8IXW7;Q06787-6;Q06787-4;Q06787-7;Q06787-10;Q06787-5;Q06787-3;Q06787 A8MQB8;Q06787-6 FMR1 Fragile X mental retardation protein 1 0 12577000.0 2359200.0 6861600.0 3356200.0 False True 3054030.906784472 6479745.928168848 2745406.0375200817 1.0 2.12170280064102 0.8989450733524713 21.542283231602706 -6.665538786196147 1.954255645552861 1.7187389146421284 0.9040788861085846 0.2590901789067319 0.47697577286667164 0.4713754112731824 3.4665670245069014 0.19684485880309135 0.528793421949779 2.1600371164485771e-07 6.665538786196147 -0.8146600285335438 AHNGSLQHLTWLGLQWNSLPALPGIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AHNGSLQHLTWLGLQWNSLPALPGIR 26 0 J3KNE0;A6NKT7;Q7Z3J3;P49792 J3KNE0;P49792 RGPD3;RGPD4;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;E3 SUMO-protein ligase RanBP2 0 121620200.0 7910000.0 46844000.0 66866200.0 False True 12000048.298459988 38484322.206157476 53650066.2615034 1.0 3.2070139426935738 4.4708208606450786 23.516536876696037 -8.60468638359907 0.262688724017445 1.3541011430106642e-17 5.340585118872721 0.9991518684450843 0.041770423479272414 0.21803976547291404 0.07531093904506005 0.6552144160719072 0.4735499938648646 2.484926893950256e-09 8.60468638359907 5.340585118872721 AHNGSLQHLTWLGLQWNSLPALPGIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHNGSLQHLTWLGLQWNSLPALPGIR 26 0 J3KNE0;A6NKT7;Q7Z3J3;P49792 J3KNE0;P49792 RGPD3;RGPD4;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;E3 SUMO-protein ligase RanBP2 0 35751800.0 18644000.0 8742500.0 8365300.0 False True 15503312.069242695 8695402.417249613 10114445.553222917 1.0 0.560873855755028 0.6524054671704087 23.886073124577212 -9.95539680393222 5.803556847182956 1.000000340703455 0.6066396614625291 0.9609757314037815 0.037367623884451986 1.647142723133373e-07 2.9634555940628815e-08 0.03618107751698164 0.012060348749213653 1.1081618529931627e-10 9.95539680393222 -0.3933606792409259 AHNGSLQHLTWLGLQWNSLPALPGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHNGSLQHLTWLGLQWNSLPALPGIR 26 0 J3KNE0;A6NKT7;Q7Z3J3;P49792 J3KNE0;P49792 RGPD3;RGPD4;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;E3 SUMO-protein ligase RanBP2 0 51599000.0 7910000.0 20836000.0 22853000.0 False True 10239650.92941047 19676458.283683978 18693988.491581704 1.0 1.921594634360921 1.8256470479758802 23.287663198788486 -10.153997895446263 5.012185283091172 0.9999497653474826 1.8736208411700443 0.991034547709613 0.039170438121528824 2.198946604060094e-05 3.71165436201243e-06 0.037928781561361306 0.012642204541544631 7.014586976203015e-11 10.153997895446263 0.8736710758225618 AHPPELK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHPPELKK 8 1 P62308;A8MWD9;C9JVQ0 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 1 5079180.0 2053800.0 2770200.0 255180.0 True False 2692551.6890274943 2356896.958155028 228776.42145940373 1.0 0.8753395404662782 0.08496639911935508 21.360542609836592 -7.056783459966873 0.8062445764741708 1.0022961641252452 8.069663863337631e-22 0.9960508889352087 0.025462120356714225 0.07808999728917496 0.08619183875111047 0.023127650925477094 0.05751199567686033 8.774382044085306e-08 7.056783459966873 -1.0022961641252452 down AHPPELK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHPPELKK 8 1 P62308;A8MWD9;C9JVQ0 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 1 6867490.0 3293000.0 3174100.0 400390.0 True False 3188465.517497068 4441534.6827128325 295515.84755747067 1.0 1.3930006952684308 0.0926827798311739 21.60443084819934 -6.8256269068811655 1.3471773283095523 1.2107113888318086 0.060677142941667726 0.896877999034494 0.17485903473886275 0.1862657860643547 0.6626312411246761 0.10195033616749116 0.2347233501874942 1.4940773884016236e-07 6.8256269068811655 -1.150034245890141 down AHPVMLK(ub)QTPVLPPTITDQIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHPVMLKQTPVLPPTITDQIR 21 1 Q92759 Q92759 GTF2H4 General transcription factor IIH subunit 4 1 12392900.0 2374100.0 4529000.0 5489800.0 True False 2298735.4950166405 6337453.318422998 4051856.689530219 1.0 2.756930204524084 1.7626458974136507 21.132409040608007 -10.064376260314873 4.82807621440893 0.9999617150755349 2.259788050984976 0.6815780189790634 0.4059148686683779 140777618.60040334 3.3881833768034175 59918.23185314132 0.13895545623938682 8.622312116232522e-11 10.064376260314873 1.2598263359094413 AHPVMLK(ub)QTPVLPPTITDQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AHPVMLKQTPVLPPTITDQIR 21 1 Q92759 Q92759 GTF2H4 General transcription factor IIH subunit 4 1 31276600.0 4921500.0 5212100.0 21143000.0 True False 7466275.309844604 4281960.032676832 16964076.782693896 1.0 0.5735068497984376 2.272093658309925 22.83195727657546 -6.840187350977928 1.2815417984760777 0.7731294359625792 2.3281679034663916 0.9247854899657045 0.19787867611141371 0.16856835983985818 0.5377022329028741 0.12107368930207826 0.27894169280769426 1.4448163546933077e-07 6.840187350977928 1.5550384675038122 up AHPVMLK(ub)QTPVLPPTITDQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHPVMLKQTPVLPPTITDQIR 21 1 Q92759 Q92759 GTF2H4 General transcription factor IIH subunit 4 1 12802200.0 2374100.0 4784700.0 5643400.0 True False 1974169.340462836 4758923.871411408 6823408.847866555 1.0 2.410595572462744 3.4563442497120507 20.912814316042283 -7.767685380365898 0.18742904805390856 3.8370194429950014e-25 5.0522938153877925 0.9999181223888748 0.009107247751815387 0.13276600261677768 0.026121457581227244 0.2375992295054964 0.37151249427028527 1.7073187885284462e-08 7.767685380365898 5.0522938153877925 AHPVMLK(ub)QTPVLPPTITDQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHPVMLKQTPVLPPTITDQIR 21 1 Q92759 Q92759 GTF2H4 General transcription factor IIH subunit 4 1 21306900.0 4921500.0 5065400.0 11320000.0 True False 6370978.767268473 4783506.037155545 9259876.153008563 1.0 0.7508274963544496 1.4534463998816136 22.603083598667908 -6.810860766007297 1.4111122824761635 0.8643425341176225 1.4659582477834041 0.8620130491958916 0.10804302759719571 0.20563119238507932 0.8068794592405851 0.060204063939706544 0.13919779497807253 1.5457499246220758e-07 6.810860766007297 0.6016157136657816 AHQLWLSVEALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHQLWLSVEALK 12 0 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 0 5835800.0 2529300.0 1448100.0 1858400.0 False True 2449008.7559688245 2026333.8817417386 1371629.2891950428 1.0 0.8274098150131455 0.5600752899931662 21.223766501319254 -6.964717990261467 0.36285986416749233 1.0222965512695867 0.3559864479700232 0.9999072125432659 0.0017433177058973847 0.07805678986408376 0.015198177451747476 0.0035667012820448808 0.022795286265860547 1.0846309920743289e-07 6.964717990261467 -0.6663101032995635 AHQLWLSVEALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AHQLWLSVEALK 12 0 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 0 18945000.0 3866800.0 9255500.0 5822700.0 False True 5866218.300946289 7603783.711448427 4671840.7928199265 1.0 1.2961985595084058 0.7963973642212232 22.483999328764178 -6.7461120329488695 1.6639910728877783 1.1749721356380776 0.795675373693074 0.6322158711133347 0.12444815324575828 0.30685491429180084 1.6703588354622274 0.05910892462529989 0.14410481805795192 1.7942707073693616e-07 6.7461120329488695 -0.3792967619450036 AHQLWLSVEALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHQLWLSVEALK 12 0 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 0 5665300.0 2529300.0 1250300.0 1885700.0 False True 2103225.016988606 1243564.3857348813 2279991.151508304 1.0 0.5912654973624337 1.0840452795549147 21.00417177675353 -6.686472112344833 1.8787557209555785 0.7429105399578732 1.082282692898354 0.35405342603984624 0.17299117074369674 0.42429620739322477 2.900782117854185 0.07373423216292782 0.19288117689854878 2.058391063202654e-07 6.686472112344833 0.33937215294048084 AHQLWLSVEALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHQLWLSVEALK 12 0 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 0 17353600.0 3866800.0 7393900.0 6092900.0 False True 5005648.826023321 6982422.965239532 4984054.718433381 1.0 1.394908673764603 0.9956860522300972 22.255125650856627 -10.744707348314694 12.706122625888595 0.9998885937426258 1.19529736299732 0.24189655378132324 0.1629819527559638 0.0005146531394584728 1.0340343820963839e-05 0.1578949416399111 0.052602199063017656 1.80008350253169e-11 10.744707348314694 0.1954087692546942 AHQVVEDGYEFFAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHQVVEDGYEFFAKR 15 1 P36873;P36873-2;F8VYE8;F8W0W8;P62140;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 35227800.0 9387000.0 7174800.0 18666000.0 True False 12306447.903837308 6104347.807151352 16734621.376915237 1.0 0.49602841167904654 1.3598254758545858 23.552911070955037 -6.748562888034438 1.6552014406931628 0.7031447764742388 1.361350648457508 0.642727988613716 0.2117590353752695 0.30256886598801824 1.6305076226747386 0.10108360562367091 0.2457714465660896 1.7841736124834608e-07 6.748562888034438 0.6582058719832692 AHQVVEDGYEFFAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHQVVEDGYEFFAKR 15 1 P36873;P36873-2;F8VYE8;F8W0W8;P62140;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 63884300.0 8376600.0 9848700.0 45659000.0 True False 8110689.418119026 13781337.270292014 33699538.15936103 1.0 1.6991573169482903 4.154953595446192 22.95139311975048 -6.947862245360511 0.5818397000041986 0.9708426604844266 5.005120386637823 0.9990226690077831 0.04229532488731176 0.08435568000083302 0.03960374245665378 0.04422674344322419 0.2052506400006944 1.1275550506523607e-07 6.947862245360511 4.034277726153396 AHQVVEDGYEFFAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 AHQVVEDGYEFFAKR 15 1 P36873;P36873-2;F8VYE8;F8W0W8;P62140;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 188695000.0 16172000.0 53523000.0 119000000.0 True False 24534106.331566997 43971402.47289232 95479597.8404472 1.0 1.7922561302473927 3.891708813440563 24.548285385607578 -6.954201434768668 0.5106402099742009 0.9615638445675817 4.814607911557687 0.9994910842814955 0.027523974025733842 0.08184124174290106 0.029310116385540756 0.03166730904544863 0.17328035967412656 1.11121620266332e-07 6.954201434768668 3.853044066990105 AHQVVEDGYEFFAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHQVVEDGYEFFAKR 15 1 P36873;P36873-2;F8VYE8;F8W0W8;P62140;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 38245300.0 9387000.0 8566300.0 20292000.0 True False 12857627.574136648 8187812.541034053 15499447.5268583 1.0 0.6368058565877259 1.2054671390572644 23.61612113247793 -6.734263163121061 1.708536702187274 0.7824646051220829 1.2053462545243812 0.5785526066218755 0.15263285043140137 0.32829860694442203 1.8794749182281039 0.07075332101205814 0.1746715625236023 1.8438977606361687e-07 6.734263163121061 0.4228816494022982 AHQVVEDGYEFFAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHQVVEDGYEFFAKR 15 1 P36873;P36873-2;F8VYE8;F8W0W8;P62140;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 42301600.0 8376600.0 10176000.0 23749000.0 True False 6965514.046300065 10121179.868222155 28714806.09703066 1.0 1.4530413406600355 4.122424548448562 22.731798395184757 -6.936221190387559 0.6938382303221455 0.9671971034911226 4.768698745342177 0.9976256985774123 0.06712673731807141 0.08953392831834607 0.06278439298582852 0.06360371929870759 0.2338283775389897 1.1581873298859212e-07 6.936221190387559 3.801501641851054 up AHQVVEDGYEFFAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHQVVEDGYEFFAKR 15 1 P36873;P36873-2;F8VYE8;F8W0W8;P62140;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 136154000.0 16172000.0 39117000.0 80865000.0 True False 20934972.797778275 36940104.56339345 66148399.74496795 1.0 1.7645164825489394 3.1597079386694 24.319411707700027 -6.961796025577701 0.409336190762047 0.9307723465497243 4.045173078397971 0.9998311185707788 0.011619745026048591 0.07906568383816324 0.018805966586598184 0.0179624994376355 0.116513178402317 1.0919530719536967e-07 6.961796025577701 3.1144007318482467 AHSFLMDFIHQVGLFGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AHSFLMDFIHQVGLFGR 17 0 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 0 56609800.0 17264000.0 16947100.0 22398700.0 False True 26190750.167460587 13922757.596703341 17971587.12730102 1.0 0.5315906382094007 0.6861806940386509 24.6425540468239 -10.369303370645673 5.291219842068269 1.0001799489069754 0.6088856661240126 0.8951188128063118 0.063111126015051 0.0001340324626524269 1.597631359517821e-05 0.06113490202311035 0.020369028334717477 4.2726432206390377e-11 10.369303370645673 -0.39129428278296274 AHSFLMDFIHQVGLFGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHSFLMDFIHQVGLFGR 17 0 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 0 56982400.0 17264000.0 23186500.0 16531900.0 False True 22348588.324316356 21896150.892428435 13523263.831618572 1.0 0.9797554357652359 0.6051059527954434 24.41368036891635 -6.918063971982035 0.8389587961213859 1.0088572378600424 0.5473008570921479 0.9936260323179718 0.014496134484851191 0.0993244536399577 0.11161533410959844 0.012363507387728203 0.036376162078883764 1.207635936105606e-07 6.918063971982035 -0.4615563807678945 AHSIQIMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHSIQIMK 8 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 46508000.0 13023000.0 14721000.0 18764000.0 False True 17073279.1149114 12524684.182008564 16822481.27699762 1.0 0.7335839880383493 0.9853105056020117 24.025236834966996 -10.561453297249022 8.442645010191049 1.0000278833676943 0.8594472468884383 0.2936258617735016 0.10276692045978675 5.3946770775155034e-05 2.8021165488129646e-06 0.0995233536157413 0.0331678809568147 2.7450275197912216e-11 10.561453297249022 -0.140580636479256 AHSIQIMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHSIQIMK 8 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 42233000.0 13023000.0 12678000.0 16532000.0 False True 17837955.033342026 12117844.039460408 12627482.087227548 1.0 0.6793292177724518 0.7078996478926389 24.088446896489888 -10.260087602702471 7.103073767929647 1.0000017006537691 0.6936144328325453 0.9935205939913975 0.01166382925438365 3.141338830520998e-07 3.271892844431094e-08 0.011293516707471979 0.0037644847046028993 5.4943003567604746e-11 10.260087602702471 -0.30638726782122383 AHSSMVGVNLPQK ddPTM_RPMI8226_Bortezomib_1h_R1 2 AHSSMVGVNLPQK 13 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 197890890.0 49838700.0 47694290.0 100357900.0 False True 65339018.33865739 40578487.84288636 89973827.2089532 1.0 0.6210452632233437 1.3770305936127112 25.961441443924922 -6.77040336253197 1.5727581930891252 0.782753168671315 1.3813629403712089 0.7321497330732092 0.15972917683071328 0.2657802436061097 1.2974834192748665 0.08004678558499306 0.19048591148693608 1.696667095823493e-07 6.77040336253197 0.5986097716998939 AHSSMVGVNLPQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHSSMVGVNLPQK 13 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 112873700.0 34244000.0 12506700.0 66123000.0 False True 33156942.964217912 17500690.53157888 48803402.652520336 1.0 0.5278137538332517 1.471890900955123 24.982807662188982 -6.7707543408366835 1.5718761457568433 0.7294195172991309 1.4773114774057365 0.7333015219595569 0.19904081229738835 0.2652257381285546 1.2934484899908263 0.09980964397831539 0.23739430233852898 1.695296475646657e-07 6.7707543408366835 0.7478919601066056 AHSSMVGVNLPQK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AHSSMVGVNLPQK 13 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 142314500.0 49838700.0 41000600.0 51475200.0 False True 68265414.23022527 39189057.92114697 39317817.9250215 1.0 0.574068997647649 0.5759551651209801 26.024651505447814 -9.940785791898817 5.349456387561686 1.0000009165504438 0.5750120813822613 0.9999852263909086 0.0007700246537129974 8.417304183412401e-09 1.6677008550993476e-09 0.0007455747727199296 0.0002485243872933839 1.1460780848826978e-10 9.940785791898817 -0.4249888351681824 AHSSMVGVNLPQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AHSSMVGVNLPQK 13 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 66227400.0 34244000.0 18731500.0 13251900.0 False True 28475403.266420655 18630589.691588346 16022811.020137304 1.0 0.6542695644123955 0.562689520855076 24.76321293762326 -13.999999999999998 0.1864735629813611 2.8313084091701946 0.49460593520435353 0.9994917396505847 0.0042454484703816 12.295438542524305 0.13693280996032475 8.172270261856971 0.06479315806840576 1.0000000000000041e-14 13.999999999999998 -2.336702473965841 AHSSMVGVNLPQK(ub)AGGFLMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHSSMVGVNLPQKAGGFLMK 20 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 11222700.0 1722200.0 5721800.0 3778700.0 True False 2257820.877808522 4868129.743401714 3387716.371849865 1.0 2.156118667893088 1.5004362857774787 21.106499605059625 -10.045704447436352 4.845645965509751 0.9999803212778188 1.8282774768472718 0.6802727442683487 0.2676812116273091 185327588.35963595 1.6721872301244896 40691.587849543546 0.09163439863662833 9.001099293896659e-11 10.045704447436352 0.828297155569453 AHSSMVGVNLPQK(ub)AGGFLMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHSSMVGVNLPQKAGGFLMK 20 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 39211900.0 10541200.0 12726600.0 15944100.0 True False 10206575.375961158 17808397.748342264 11767861.897252843 1.0 1.74479657400906 1.1529686955498193 23.282995542483818 -10.075434013429573 4.466153182577504 0.9999702888063304 1.448882634492708 0.43407930603769007 0.24161271973748974 83887131.90480743 1.6502747182517277 28755.59910640149 0.08271046047163765 8.405547110231269e-11 10.075434013429573 0.4489123456863775 AHSSMVGVNLPQK(ub)AGGFLMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHSSMVGVNLPQKAGGFLMK 20 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 8152300.0 1722200.0 3599700.0 2830400.0 True False 2358943.88070503 3440653.3513839487 2161917.8139177915 1.0 1.458556678489368 0.9164770012551751 21.169709666582516 -6.682536488159753 1.8931960303475388 1.2894788419491037 0.9185145471202074 0.3356139561918612 0.1942415931987382 0.43292097626967485 3.0022358282899293 0.08226768991749345 0.21624755153864633 2.077129203884352e-07 6.682536488159753 -0.37096429482889626 AHTGEKPFECK(ub)ECGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHTGEKPFECKECGK 15 2 Q14592-2;Q14592;Q5CZA5-2;Q5CZA5;O43296 Q14592-2 ZNF460;ZNF805;ZNF264 Zinc finger protein 460;Zinc finger protein 805;Zinc finger protein 264 1 17827400.0 3268400.0 1499000.0 13060000.0 True False 4231008.229795855 1415579.3322730986 10683214.006916245 1.0 0.33457257830514786 2.524980672852936 22.012570061228345 -6.825198528269651 1.3491231419652763 0.6430821562346731 2.578384972649708 0.8959329455090115 0.2957846575127509 0.18682219749722778 0.6666773118911445 0.17221315638092305 0.3965043957688592 1.4955518408385012e-07 6.825198528269651 1.935302816415035 up AHVIVMAATNRPNSIDPALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AHVIVMAATNRPNSIDPALR 20 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 9815800.0 2852000.0 3632700.0 3331100.0 False True 3738999.6188072846 3090715.3201536965 2986429.7261674865 1.0 0.8266155750878663 0.7987242660164103 21.834220893436846 -13.999999999999968 0.25715751370160084 2.250669605309855 0.7882491784117676 0.9995565853848235 0.0018749287980135794 14.293190434014472 0.1604651804646411 9.273708211221944 0.01237892858938412 1.0000000000000737e-14 13.999999999999968 -1.4624204268980874 AHVIVMAATNRPNSIDPALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AHVIVMAATNRPNSIDPALR 20 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 28309300.0 8197100.0 7658200.0 12454000.0 False True 7936887.547365683 10716159.196985418 9191923.788008543 1.0 1.3501714788112624 1.1581270029533701 22.92014193433654 -10.169053095792796 4.178678306144705 0.9999166592838621 1.2541492409082418 0.7001624175016188 0.07840182906315446 54947570.53780555 7.494851735002465 45292.68046336779 0.026839031439741135 6.775586658632936e-11 10.169053095792796 0.25423258162437967 AHVIVMAATNRPNSIDPALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHVIVMAATNRPNSIDPALR 20 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 42057000.0 13666000.0 13596000.0 14795000.0 False True 18718689.50976365 12995283.764040384 11300725.712589625 1.0 0.6942411089869329 0.6037135081863064 24.15797609999049 -13.999999999999998 0.17060137658277588 2.544393201385718 0.5243669087540793 0.9995125427417515 0.0037434078704452916 12.097456613839562 0.13080841961283013 6.183289455016942 0.07340403858734715 1.0000000000000041e-14 13.999999999999998 -2.0200262926316386 AHVIVMAATNRPNSIDPALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHVIVMAATNRPNSIDPALR 20 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 87578000.0 14534000.0 52836000.0 20208000.0 False True 18814549.50797117 49895630.15342326 16530351.35158986 1.0 2.6519704940202766 0.8785940553392702 24.165345410412616 -6.662043715330283 1.965065578533616 2.0615033407495744 0.8858615528753881 0.24462480126142871 0.7030180873934995 0.4795765060607333 3.5618968701984173 0.2887855677799009 0.7798020203211665 2.1774905788916081e-07 6.662043715330283 -1.1756417878741863 AHVIVMAATNRPNSIDPALRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AHVIVMAATNRPNSIDPALRR 21 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 37817800.0 7561100.0 8557100.0 21699600.0 False True 11470741.490453335 7030018.648072535 17410664.548727464 1.0 0.6128652322888939 1.5178325274976951 23.45145531711924 -6.79043638248994 1.4944091157589507 0.7837590193038727 1.5276011287988656 0.802816307229177 0.16462556467363218 0.23468479450238933 1.035363422798562 0.08670469414755 0.20294831918534184 1.620181308343753e-07 6.79043638248994 0.7438421094949929 AHVIVMAATNRPNSIDPALRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AHVIVMAATNRPNSIDPALRR 21 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 61179100.0 7561100.0 31172000.0 22446000.0 False True 9787993.001563283 29437250.797609787 18361058.315409042 1.0 3.0074858852992885 1.8758757093999268 23.22258163921169 -10.472185410404359 6.015186559234912 0.9990362468568095 2.441680797349606 0.6839573249387925 0.46197791978242647 0.00597379489574096 0.0005241809764796569 0.4475268770684726 0.14910273246940686 3.371433436037514e-11 10.472185410404359 1.4426445504927967 AHWTPFEGQK(ub)VK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AHWTPFEGQKVK 12 1 F8VPD4;P27708;H7BZB3 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 3203880.0 801080.0 1398800.0 1004000.0 True False 1097260.924373004 1336996.3907869728 766875.8780290631 1.0 1.2184853767128894 0.6989001986626571 20.065475203121913 -6.792495588603756 1.4865250356775481 1.1217179257140149 0.6930024424689613 0.8092435934341399 0.09303426768642463 0.23165930884264746 1.011249468126353 0.04925662463124917 0.11510686501384548 1.6125174065859245e-07 6.792495588603756 -0.4287154832450536 AIACLLFGGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIACLLFGGSR 11 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 176272000.0 49925000.0 63270000.0 63077000.0 False True 65452158.47438781 53830362.62452836 56550397.11730861 1.0 0.822438310351412 0.8639959083921952 25.96393743421166 -10.706977379834425 6.7617056697823505 1.0016366882146164 0.8432171093718036 0.9499432645246646 0.01696581835593412 0.00042269702904398535 1.8317801807826393e-05 0.0165878754152871 0.005475694328942744 1.963462540836626e-11 10.706977379834425 -0.15841957884281277 AIACLLFGGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIACLLFGGSR 11 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 189638000.0 49900000.0 56948000.0 82790000.0 False True 75701948.17865409 46785184.46324515 66426520.21185395 1.0 0.6180182358429359 0.8774743822324039 26.17382709244787 -10.20378728284469 5.283386429235671 1.0000156724758806 0.7477463090376032 0.5575876292434572 0.10592252821407616 1.9555406035358065e-05 2.9470124097941645e-06 0.1025654147146137 0.03418634898007475 6.254789769575442e-11 10.20378728284469 -0.25226936343827744 AIACLLFGGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIACLLFGGSR 11 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 199630000.0 49925000.0 65141000.0 84564000.0 False True 68383621.67239511 62262855.22751944 64591724.85024878 1.0 0.9104936782348502 0.9445496344093598 26.02714749573455 -10.281293913714723 7.083050520831756 1.000000588270103 0.9275216564812431 0.8579354870040069 0.013903285888355797 1.2915394366827424e-07 1.3112663241622898e-08 0.013461908000467857 0.004487266225263546 5.232462039326337e-11 10.281293913714723 -0.07247893178886 AIACLLFGGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIACLLFGGSR 11 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 209413000.0 49900000.0 99265000.0 60248000.0 False True 64596533.67605346 93740815.48905212 49283482.196683794 1.0 1.4511740824849046 0.7629431393925343 25.94495341454032 -6.729833857419791 1.7236335207165832 1.271563644713002 0.7633504583506666 0.5585615162383073 0.1896657808186468 0.33656162295303665 1.9587738876494716 0.08719987756637505 0.21643800891160317 1.8627996282052888e-07 6.729833857419791 -0.5082131863623355 AIADTGANVVVTGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIADTGANVVVTGGK 15 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 63607000.0 15948000.0 22746000.0 24913000.0 False True 20907982.440651707 19352385.46321358 22335241.7423706 1.0 0.9255979393586272 1.0682638463931293 24.31755051699029 -6.765016627884176 1.593862721489434 0.9570530734069415 1.068913242808286 0.7110061387526814 0.0313200776628206 0.27456916382823543 1.3757946250518567 0.015497431423570115 0.037056554601290245 1.717842614655186e-07 6.765016627884176 0.11186016940134447 AIADTGANVVVTGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIADTGANVVVTGGK 15 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 32830900.0 12000000.0 4621900.0 16209000.0 False True 11619066.568467917 6467448.7728900835 11963376.640423184 1.0 0.556623781676369 1.0296331955692262 23.469990836987236 -11.77585184408172 13.617784162891496 0.9033126041830337 0.8138156397602752 0.0 0.2216524947276486 0.0 0.0 0.0 0.06432606088332873 1.6755143662079307e-12 11.77585184408172 -0.08949696442275856 AIADTGANVVVTGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIADTGANVVVTGGK 15 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 119003000.0 10105000.0 90330000.0 18568000.0 False True 15330023.774454912 74209905.74848871 14898026.661356505 1.0 4.840821308584525 0.971820192880701 23.869856598602983 -6.6478560791241295 2.0156750607684564 3.4965964100886415 0.9879582500813773 0.18538085881702315 1.640189890472067 0.5139694249860688 3.999991363210656 0.6604037574842728 1.8171122808295936 2.2498000436926143e-07 6.6478560791241295 -2.5086381600072643 AIADTGANVVVTGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIADTGANVVVTGGK 15 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 52226000.0 15948000.0 19967000.0 16311000.0 False True 21844406.57849488 19084791.917960733 12458677.735589704 1.0 0.873669506625513 0.5703372023781536 24.380760578513183 -6.95632114788342 0.48451179970500663 1.0069805220921897 0.4242826959794363 0.9996084678522613 0.003567666151379448 0.08104250538907777 0.02619387434125662 0.004316804422302062 0.025019252691276344 1.1058057710094729e-07 6.95632114788342 -0.5826978261127533 AIADTGANVVVTGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIADTGANVVVTGGK 15 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 23548900.0 12000000.0 7078900.0 4470000.0 False True 9978531.690136908 7040764.560648367 5404656.333055167 1.0 0.7055912412051243 0.5416284179762939 23.250396112421512 -12.899981739130716 0.07739168449366163 2.402548320141793 1.9634165814711803e-21 0.9999200447385888 0.0016956940979772298 8.326073111552414 0.06696135479278578 2.2916199547530414 0.44381261641908587 1.2589783472024232e-13 12.899981739130716 -2.402548320141793 AIADTGANVVVTGGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIADTGANVVVTGGK 15 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 47872000.0 10105000.0 23400000.0 14367000.0 False True 13081121.699329073 22097769.42974682 11752353.417868726 1.0 1.6892870456881546 0.8984209219971939 23.640982920695432 -6.67637819449814 1.915000420576973 1.4375441097862725 0.9015311272015178 0.3074669458961684 0.2923730217897915 0.44665248741054425 3.1636954082949416 0.12265780653376177 0.32498146543240114 2.1067927030883025e-07 6.67637819449814 -0.5360129825847546 AIAEGLGSELLVGTTK(ub)NALLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIAEGLGSELLVGTTKNALLR 21 1 G3V195;G3V1D0;B7WPE2;H0Y3M3;Q32P44;Q32P44-2 G3V195 EML3 Echinoderm microtubule-associated protein-like 3 1 38525730.0 907730.0 18644000.0 18974000.0 True False 1190042.8204698241 15862387.873742802 17010752.491459873 1.0 13.3292580744955 14.294235634936308 20.18258205526749 -9.521836422127882 0.7487807874933018 6.937930337196931e-14 14.115954495785658 0.999334381507776 0.156148112541784 0.8606785459502267 0.3709767799999938 2.8207933260700155 0.14359127201564542 3.0072087604470827e-10 9.521836422127882 14.115954495785589 AIAEGLGSELLVGTTK(ub)NALLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIAEGLGSELLVGTTKNALLR 21 1 G3V195;G3V1D0;B7WPE2;H0Y3M3;Q32P44;Q32P44-2 G3V195 EML3 Echinoderm microtubule-associated protein-like 3 1 240038800.0 62163200.0 101442600.0 76433000.0 True False 60189863.24241538 141949159.19617066 56412904.35915022 1.0 2.3583565661956856 0.9372492529505606 25.843017203002393 -6.6564430850175516 1.985954049058897 1.876916744842537 0.943251854853784 0.22048276093336971 0.578854523007293 0.49288786211047264 3.733258799652685 0.23582344173464675 0.6412911571972685 2.2057531849145714e-07 6.6564430850175516 -0.933664889988753 AIAEGLGSELLVGTTK(ub)NALLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIAEGLGSELLVGTTKNALLR 21 1 G3V195;G3V1D0;B7WPE2;H0Y3M3;Q32P44;Q32P44-2 G3V195 EML3 Echinoderm microtubule-associated protein-like 3 1 417425600.0 169059000.0 118519000.0 129847600.0 True False 256474862.86843842 97368358.45682655 104183164.94577508 1.0 0.3796409416807943 0.4062119920080315 27.9342421931489 -10.551815743303543 6.313895921700708 1.000898364431186 0.3929264668444162 0.9985652617202792 0.010847585871923865 0.00013735759758687403 9.750145008010533e-06 0.010516870947469188 0.0035010432857096618 2.8066241426145084e-11 10.551815743303543 -0.6079718975867698 AIAEGLGSELLVGTTK(ub)NALLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIAEGLGSELLVGTTKNALLR 21 1 G3V195;G3V1D0;B7WPE2;H0Y3M3;Q32P44;Q32P44-2 G3V195 EML3 Echinoderm microtubule-associated protein-like 3 1 72327730.0 907730.0 28295000.0 43125000.0 True False 1243342.3114808842 27044833.340947535 32939763.187254336 1.0 21.75171961190298 26.492915814970853 20.24579211679038 -8.995254069904837 0.6241131034396478 2.7550317536608437e-17 26.046695636838603 0.9964249944835548 0.6619194881683296 0.4890265846918115 0.2694995856091993 2.809264170842226 0.8096193380108888 1.0109878355707257e-09 8.995254069904837 26.046695636838603 AIAEGLGSELLVGTTK(ub)NALLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIAEGLGSELLVGTTKNALLR 21 1 G3V195;G3V1D0;B7WPE2;H0Y3M3;Q32P44;Q32P44-2 G3V195 EML3 Echinoderm microtubule-associated protein-like 3 1 173314000.0 62163200.0 64952800.0 46198000.0 True False 51691455.096693195 64602886.374278575 55857788.204582244 1.0 1.2497788319836125 1.080600035346182 25.62342247843667 -10.510281566523059 4.109259047655685 0.9983945312789692 1.1651894336655435 0.5597027109490628 0.06906695451325848 0.0010255077198385038 0.00012221418613912215 0.06750828343713683 0.022291263716472706 3.0882925478965734e-11 10.510281566523059 0.16679490238657435 AIAEGLGSELLVGTTK(ub)NALLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIAEGLGSELLVGTTKNALLR 21 1 G3V195;G3V1D0;B7WPE2;H0Y3M3;Q32P44;Q32P44-2 G3V195 EML3 Echinoderm microtubule-associated protein-like 3 1 329804200.0 169059000.0 99346900.0 61398300.0 True False 218850208.15110058 93818157.68205619 50224439.39975848 1.0 0.4286866276009269 0.2294923081136942 27.70536851524135 -13.999999999964565 0.14692055186501032 3.7502816982014506 0.002385775722276305 0.999576842037567 0.0067175520778553054 11.947486850898365 0.12054932712440788 9.39022624930773 0.20412108184090028 1.0000000000815916e-14 13.999999999964565 -3.747895922479174 AIAELGIYPAVDPLDSTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIAELGIYPAVDPLDSTSR 19 0 P06576;H0YH81 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 62926960.0 18766000.0 30473960.0 13687000.0 False True 24602407.730202537 25927363.95456568 12270800.534974752 1.0 1.0538547380765744 0.49876421322417186 24.55229617694855 -6.8830769101104075 1.0624436649873852 1.0349604770187741 0.4570207981830457 0.9760856704435167 0.03865250556165529 0.12494150981788059 0.25608751880930863 0.027941822592495686 0.06813370651567306 1.30895009778559e-07 6.8830769101104075 -0.5779396788357285 down AIAELGIYPAVDPLDSTSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIAELGIYPAVDPLDSTSR 19 0 P06576;H0YH81 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 150405000.0 55788000.0 30485000.0 64132000.0 False True 54017040.47680734 42657819.47717482 47333905.28124006 1.0 0.7897104154658436 0.8762772796033367 25.686911262844113 -10.102730589641519 5.358090699972014 1.0000026006479823 0.832993847549097 0.8322850431575546 0.03534077429531806 1.0979327067272034e-06 1.8386217683241518e-07 0.03421909038452693 0.011406185857266835 7.893496311378978e-11 10.102730589641519 -0.1670087530988853 AIAELGIYPAVDPLDSTSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIAELGIYPAVDPLDSTSR 19 0 P06576;H0YH81 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 303985000.0 25204000.0 214180000.0 64601000.0 False True 38236310.65921436 175957905.60402188 51832584.034375906 1.0 4.601853645668577 1.3555853883587237 25.188439991650746 -6.621253279652477 2.111873786615636 3.3877518926356838 1.3679815630074001 0.08714451097910769 1.5484085771538052 0.582016594573723 4.934213221650108 0.6020471729325068 1.7169513010745154 2.39192038648539e-07 6.621253279652477 -2.0197703296282836 AIAELGIYPAVDPLDSTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIAELGIYPAVDPLDSTSR 19 0 P06576;H0YH81 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 100580000.0 18766000.0 32673000.0 49141000.0 False True 25704297.332081456 31229398.824837577 37534907.890663505 1.0 1.2149485520407617 1.4602580808080017 24.61550623847144 -6.9694016969798955 0.2720955775705741 0.9405463106598653 1.7420558111199775 0.9999773323425767 0.0008952304021121497 0.0764972976522099 0.009722747261094495 0.004747694739808627 0.022750032544442137 1.0729964942533934e-07 6.9694016969798955 0.8015095004601123 AIAELGIYPAVDPLDSTSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIAELGIYPAVDPLDSTSR 19 0 P06576;H0YH81 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 117427000.0 55788000.0 32535000.0 29104000.0 False True 46390193.82744647 32359727.497308135 35189511.838308215 1.0 0.6975553414946652 0.7585549646375601 25.46731653827839 -10.757292287429962 6.959063091988939 1.0055649663835609 0.7280551530661454 0.9636363800214247 0.024902991867026724 0.002176857698956779 7.592106081894532e-05 0.02441183893052538 0.008037406064311099 1.7486694088262518e-11 10.757292287429962 -0.2775098133174154 AIAELGIYPAVDPLDSTSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIAELGIYPAVDPLDSTSR 19 0 P06576;H0YH81 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 153479000.0 25204000.0 67612000.0 60663000.0 False True 32627074.845115244 63849332.76427532 49622956.454943314 1.0 1.9569432156384228 1.5209134343335902 24.959566313743196 -10.21306305376403 4.910493910657434 0.9998989925907648 1.7389283249871914 0.7929275021222297 0.17800841281312588 0.0001968701545966307 3.1549506068166206e-05 0.17237923383587833 0.05745196819191996 6.12261493072023e-11 10.21306305376403 0.7390293323964267 AIAGGDEK(ub)GAAQVAAVLAQHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIAGGDEKGAAQVAAVLAQHR 21 1 Q9H0F6;Q9H0F6-2 Q9H0F6 SHARPIN Sharpin 1 15165500.0 3179800.0 5944100.0 6041600.0 True False 4168748.5932270074 5057263.449920323 5416473.187119421 1.0 1.2131370690323928 1.2993043514112603 21.991182938774077 -13.946927599744221 0.12518803019009223 1.4218314228706469e-08 1.4280136120993996 0.9996683343218397 0.0022910599754366887 11.742249343630784 0.10910528970758168 2.9112120576860856 0.11399748528709283 1.1299842761075561e-14 13.946927599744221 1.4280135978810853 AIAGGDEK(ub)GAAQVAAVLAQHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIAGGDEKGAAQVAAVLAQHR 21 1 Q9H0F6;Q9H0F6-2 Q9H0F6 SHARPIN Sharpin 1 38760800.0 9493400.0 9549400.0 19718000.0 True False 9192037.213424426 13362525.219463127 14553264.272679674 1.0 1.4537066059684736 1.5832468836642104 23.13195320798642 -11.830465874473376 0.2130000829185635 1.4912983477437043e-12 1.6664125986330922 0.999371282511308 0.006270269260674212 4.801523699231032 0.1287694623614507 2.221317494190762 0.07468649618593054 1.4775225762147873e-12 11.830465874473376 1.666412598631601 AIAGGDEK(ub)GAAQVAAVLAQHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIAGGDEKGAAQVAAVLAQHR 21 1 Q9H0F6;Q9H0F6-2 Q9H0F6 SHARPIN Sharpin 1 14858000.0 3179800.0 4448600.0 7229600.0 True False 4355457.990863935 4252046.142447042 5522117.378285773 1.0 0.9762569519362118 1.2678614717141201 22.05439300029697 -6.887164173471498 1.0389718304292757 0.9832501788048941 1.2915954375793435 0.9790217748944858 0.019151020051744863 0.12147588121368626 0.23550903287743744 0.01409388992124571 0.03479735468450277 1.2966889995537905e-07 6.887164173471498 0.3083452587744494 AIAGGDEK(ub)GAAQVAAVLAQHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIAGGDEKGAAQVAAVLAQHR 21 1 Q9H0F6;Q9H0F6-2 Q9H0F6 SHARPIN Sharpin 1 33189100.0 9493400.0 10849000.0 12846700.0 True False 7894182.728928794 10790554.28364211 15532885.573570428 1.0 1.3668994820830984 1.9676369431694385 22.912358483420697 -6.963760766860105 0.3787230881888415 0.9581380929047447 2.397598813134577 0.9998852705503259 0.00427228598623058 0.07838409038291834 0.016358711186085322 0.007828598608246678 0.0507930451905978 1.0870242510996278e-07 6.963760766860105 1.4394607202298322 AIAGGDEK(ub)GAAQVAAVLAQHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIAGGDEKGAAQVAAVLAQHR 21 1 Q9H0F6;Q9H0F6-2 Q9H0F6 SHARPIN Sharpin 1 53893500.0 6590500.0 21640900.0 25662100.0 True False 8531532.16817696 20436564.891119994 20991861.115381707 1.0 2.395415558221699 2.460503072787136 23.024373426100166 -10.713695636480285 0.5675711986996278 3.1525921095927267e-22 2.4541981981109617 0.9998300832016593 0.008781439998596147 2.2625770494118926 0.2761357222147801 3.1462580158273634 0.011825755545914671 1.933322759218652e-11 10.713695636480285 2.4541981981109617 AIAGNDDVK(ub)DAIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIAGNDDVKDAIVR 14 1 Q6NXE6-2;Q6NXE6;B4E1N1;H0YH65;H0YGQ5 Q6NXE6-2 ARMC6 Armadillo repeat-containing protein 6 1 17273200.0 2457600.0 5922400.0 8893200.0 True False 3221937.3994322554 5038801.005334387 7973016.973598131 1.0 1.5639040678513134 2.4746033163161623 21.619497032826754 -6.964001054163506 0.374808142161893 0.9336748301763046 3.1367732414223553 0.9998910397301553 0.006341623104939513 0.07830168413921877 0.016065798475252354 0.01192313746435707 0.07715082599192746 1.0864229865380732e-07 6.964001054163506 2.2030984112460508 AIAGNDDVK(ub)DAIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIAGNDDVKDAIVR 14 1 Q6NXE6-2;Q6NXE6;B4E1N1;H0YH65;H0YGQ5 Q6NXE6-2 ARMC6 Armadillo repeat-containing protein 6 1 26959800.0 2293900.0 3259900.0 21406000.0 True False 2221081.4001173787 4561595.070153924 15799126.433765123 1.0 2.053772126457344 7.113258628400642 21.082830836316994 -6.940713704330866 0.6528894626256727 0.9438332919410095 8.506775144787694 0.9982559038143747 0.11143659231161687 0.087442520556708 0.05313808101305649 0.10907102791805416 0.43410866987649505 1.1462683356052599e-07 6.940713704330866 7.562941852846684 AIAGNDDVK(ub)DAIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIAGNDDVKDAIVR 14 1 Q6NXE6-2;Q6NXE6;B4E1N1;H0YH65;H0YGQ5 Q6NXE6-2 ARMC6 Armadillo repeat-containing protein 6 1 217020300.0 6949300.0 25971000.0 184100000.0 True False 10542596.161882186 21336272.13765083 147712554.30610368 1.0 2.023815748040721 14.011022715654539 23.329726845101796 -6.923750562363472 0.7964036725720061 0.7695264062058975 16.121365905852247 0.9951611594283357 0.4108976120656669 0.09601499064746259 0.09454132745406932 0.3612541262340145 1.1241981188213925 1.1919263960435572e-07 6.923750562363472 15.35183949964635 up AIAGNDDVK(ub)DAIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIAGNDDVKDAIVR 14 1 Q6NXE6-2;Q6NXE6;B4E1N1;H0YH65;H0YGQ5 Q6NXE6-2 ARMC6 Armadillo repeat-containing protein 6 1 15296100.0 2293900.0 4139900.0 8862300.0 True False 1907479.48700042 4117597.5369941876 10715365.955354558 1.0 2.1586588820775514 5.617552392243471 20.86323611175127 -6.9515613765464614 0.5414311389524415 0.9495500536384992 6.986785208928796 0.9993181858960647 0.05121849901611833 0.08286477149454344 0.03341401541474242 0.05622446069926612 0.2865115618474645 1.1179918135379854e-07 6.9515613765464614 6.037235155290297 AIAGNDDVK(ub)DAIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIAGNDDVKDAIVR 14 1 Q6NXE6-2;Q6NXE6;B4E1N1;H0YH65;H0YGQ5 Q6NXE6-2 ARMC6 Armadillo repeat-containing protein 6 1 243092300.0 6949300.0 14353000.0 221790000.0 True False 8996005.841182336 13554242.93269898 181426495.75757703 1.0 1.5066956571603958 20.167449750536438 23.100853167194245 -6.912718442024128 0.8770065884421473 0.4707063691296289 22.7248070904083 0.9919078772726578 0.8022829201225412 0.10264804931834746 0.12921529298368545 0.6657985016507554 1.874465925935064 1.2225920233875593e-07 6.912718442024128 22.25410072127867 up AIAGVSGFGYDHLILNVEWAKPSTN ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIAGVSGFGYDHLILNVEWAKPSTN 25 1 O75821;K7EP16 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 137782000.0 50379000.0 37301000.0 50102000.0 False True 76428626.19824484 30644345.11595679 40199317.73951332 1.0 0.4009537609176669 0.5259720047203529 26.18760976240808 -9.790902234552552 6.37259045178228 1.0000000105807176 0.46346288281939974 0.9608731771610339 0.05103848431008791 7.7467234999043e-09 1.386656155188344e-09 0.049417801409549565 0.01647259997892853 1.6184443299203322e-10 9.790902234552552 -0.5365371277613179 AIAGVSGFGYDHLILNVEWAKPSTN ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIAGVSGFGYDHLILNVEWAKPSTN 25 1 O75821;K7EP16 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 104122000.0 50379000.0 22288000.0 31455000.0 False True 65216608.618555106 21047653.207273405 25730512.755555138 1.0 0.3227345557077163 0.39453926385608495 25.95873608450053 -10.364173259379445 5.839314664891606 1.0001242543358304 0.3586369097892423 0.9906868713041217 0.029314149348832218 4.742808257504616e-05 5.1643211077359025e-06 0.028388721598439574 0.009461101019688084 4.323413164505277e-11 10.364173259379445 -0.6414873445465881 AIAHPYSQALIQYVCGLGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIAHPYSQALIQYVCGLGPR 20 0 Q7KZ85 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 10902400.0 2119900.0 0.0 8782500.0 False True 2903684.318143422 0.0 6708254.381265186 1.0 0.0 2.3102560906325924 21.4694531847085 -6.789061333669306 1.500063610419048 0.4404210461386804 2.334206156728055 0.7982873863601321 0.42486655792083167 0.2367450805938003 1.0524247568566065 0.22294892684842033 0.5223411409950909 1.625319202223709e-07 6.789061333669306 1.8937851105893746 AIAHYEQSADYYK(ub)GEESNSSANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIAHYEQSADYYKGEESNSSANK 23 1 P54920;M0R0Y2;M0R2M1;M0R058;M0R027;A0A087WZQ7;Q9H115-3;Q9H115-2;Q9H115 P54920 NAPA;NAPB Alpha-soluble NSF attachment protein;Beta-soluble NSF attachment protein 1 21755700.0 8806400.0 8258300.0 4691000.0 True False 11545275.681298915 7026193.830601277 4205620.319249405 1.0 0.6085773977647267 0.3642719702277604 23.460799286807696 -8.646288923736872 0.1687863251852402 1.4001367681304948 1.1561746936450212e-13 0.9998221100948705 0.0034923108984056318 0.22815733300943086 0.04584616513723634 0.18919710253294073 0.144710905379441 2.2579331319072522e-09 8.646288923736872 -1.4001367681303791 down AIAHYEQSADYYK(ub)GEESNSSANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIAHYEQSADYYKGEESNSSANK 23 1 P54920;M0R0Y2;M0R2M1;M0R058;M0R027;A0A087WZQ7;Q9H115-3;Q9H115-2;Q9H115 P54920 NAPA;NAPB Alpha-soluble NSF attachment protein;Beta-soluble NSF attachment protein 1 21918600.0 8938500.0 5887000.0 7093100.0 True False 8654752.21018752 8237709.800299441 5235204.3215612145 1.0 0.9518134777565118 0.6048936115581505 23.04506108443878 -6.932112461675455 0.729245307438691 1.0048841865213103 0.529684070442143 0.9969373291684529 0.009740091995116095 0.09155584323795413 0.07241525005760592 0.008987891893092358 0.0310337209045345 1.169196585346103e-07 6.932112461675455 -0.47520011607916723 AIAHYEQSADYYK(ub)GEESNSSANK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIAHYEQSADYYKGEESNSSANK 23 1 P54920;M0R0Y2;M0R2M1;M0R058;M0R027;A0A087WZQ7;Q9H115-3;Q9H115-2;Q9H115 P54920 NAPA;NAPB Alpha-soluble NSF attachment protein;Beta-soluble NSF attachment protein 1 86922000.0 27166300.0 33097600.0 26658100.0 True False 41213263.22256049 27191074.68727086 21389114.85033967 1.0 0.6597651474583124 0.5189861995356652 25.296605363418877 -13.999999999999998 0.1211473105257501 2.620338023818375 0.29772909892995497 0.9996873308023193 0.0035704733568526674 11.959510128350466 0.10726593019864013 4.658630434596879 0.1963594345650453 1.0000000000000041e-14 13.999999999999998 -2.3226089248884203 AIAHYEQSADYYK(ub)GEESNSSANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIAHYEQSADYYKGEESNSSANK 23 1 P54920;M0R0Y2;M0R2M1;M0R058;M0R027;A0A087WZQ7;Q9H115-3;Q9H115-2;Q9H115 P54920 NAPA;NAPB Alpha-soluble NSF attachment protein;Beta-soluble NSF attachment protein 1 26993300.0 8806400.0 8876900.0 9310000.0 True False 12062364.064011615 8484689.206017222 7111169.745468703 1.0 0.7034018506647067 0.5895336691656545 23.524009348330587 -13.999999999999998 0.132596739372361 2.4103617414613954 0.4352058496960895 0.9996340223611209 0.0033099352449325737 11.93356691848585 0.11348696751827093 4.376749554645062 0.13739480463611065 1.0000000000000041e-14 13.999999999999998 -1.9751558917653058 AIAHYEQSADYYK(ub)GEESNSSANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIAHYEQSADYYKGEESNSSANK 23 1 P54920;M0R0Y2;M0R2M1;M0R058;M0R027;A0A087WZQ7;Q9H115-3;Q9H115-2;Q9H115 P54920 NAPA;NAPB Alpha-soluble NSF attachment protein;Beta-soluble NSF attachment protein 1 31522200.0 8938500.0 18347700.0 4236000.0 True False 7432758.792690712 18248857.29836669 5121728.014948925 1.0 2.45519299190933 0.6890749663483728 22.825466359873058 -6.687844221551906 1.874060042147856 1.9141779738444875 0.695351393469046 0.3602579959915121 0.6157219512826628 0.4213813341917702 2.8676136382700013 0.26299928488030216 0.6867393028121479 2.0518980485803549e-07 6.687844221551906 -1.2188265803754414 AIAHYEQSADYYK(ub)GEESNSSANK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIAHYEQSADYYKGEESNSSANK 23 1 P54920;M0R0Y2;M0R2M1;M0R058;M0R027;A0A087WZQ7;Q9H115-3;Q9H115-2;Q9H115 P54920 NAPA;NAPB Alpha-soluble NSF attachment protein;Beta-soluble NSF attachment protein 1 88744100.0 27166300.0 43930600.0 17647200.0 True False 35167310.87783105 41485823.491898954 14435590.675562983 1.0 1.1796700531359365 0.4104832105505959 25.067731685511326 -6.845162678178931 1.2580930668493848 1.0956222435793241 0.38246892388476733 0.9329787231498317 0.08505454069634645 0.1628625536794142 0.49847551133180124 0.05295894082055786 0.12223818741467354 1.4283588231442047e-07 6.845162678178931 -0.7131533196945568 down AIANECQANFISIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIANECQANFISIK 14 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 16125200.0 3147800.0 7502200.0 5475200.0 False True 4126796.2833385607 6382901.00334656 4908678.825826977 1.0 1.5466964117217872 1.1894647781973569 21.976590791708084 -10.17286710453947 4.959416586157071 0.9999709118174785 1.368080594956975 0.5860153543184659 0.14583920368847822 4.692309265934863e-05 7.825751992768283e-06 0.14121934928454247 0.0470694005921094 6.716343436794362e-11 10.17286710453947 0.36810968313949644 AIANECQANFISIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIANECQANFISIK 14 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 21129000.0 3147800.0 6562200.0 11419000.0 False True 4311626.726096446 6272260.305706521 8722067.381687125 1.0 1.4547317530395645 2.0229180158143456 22.039800853230975 -6.968115662730385 0.2997992495507004 0.9012220989112814 2.5942262155370672 0.9999637273938384 0.002520240825644985 0.0769190006957644 0.011207076034791805 0.009435780810670556 0.05096891596135702 1.076178564057048e-07 6.968115662730385 1.6930041166257859 AIANLYGPLMALNHMVQQDYFPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIANLYGPLMALNHMVQQDYFPK 23 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 434620000.0 194100000.0 125870000.0 114650000.0 False True 251266276.28300563 118865223.85137743 93784876.40834208 1.0 0.4730647725980443 0.37324896040848127 27.904641811916722 -13.999999999999998 0.23394984246731873 4.388348703511261 0.3265062627676861 0.999515435055906 0.006052707900463841 13.417559453111322 0.1531220932638261 21.16567206621093 0.05057002601564468 1.0000000000000041e-14 13.999999999999998 -4.061842440743575 AIAVLTSGGDAQGMNAAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIAVLTSGGDAQGMNAAVR 19 0 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0;F8VZQ1;F8VP00;F8VX13;F8VSF7;F8VTQ3;F8VW30;F8VUB8;F8VYK8;F8VVE3 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 0 7056400.0 1557600.0 2205300.0 3293500.0 False True 2042028.6838198577 1876277.8361920733 2952720.213482819 1.0 0.9188303039320057 1.445973916467914 20.961571700825893 -6.86759715288306 1.1466516351424934 0.954692240716995 1.4754786242589142 0.9622298637192975 0.04503903837695236 0.13918387941720736 0.34351736912728226 0.030524383892340072 0.07198539605244142 1.356447055379451e-07 6.86759715288306 0.5207863835419192 AIAVLTSGGDAQGMNAAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIAVLTSGGDAQGMNAAVR 19 0 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0;F8VZQ1;F8VP00;F8VX13;F8VSF7;F8VTQ3;F8VW30;F8VUB8;F8VYK8;F8VVE3 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 0 7552500.0 1557600.0 2634300.0 3360600.0 False True 2133486.8125572875 2517907.915534833 2566895.493729549 1.0 1.1801844289427605 1.2031457043096319 21.024781762348784 -13.267466291071429 0.29995869889773685 1.7979320831619516e-12 1.2089291297410338 0.999610543053796 0.001792623279640985 10.773023888357836 0.171769995215242 6.585094472932579 0.008303106942963679 5.4017404019140334e-14 13.267466291071429 1.208929129739236 AICIDPAYSK(ub)AYGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AICIDPAYSKAYGR 14 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 257619000.0 72611000.0 107410000.0 77598000.0 True False 95193724.16592424 91384846.68090075 69568903.33257632 1.0 0.9599881450337572 0.7308139684851133 26.504363128362957 -6.936825806969118 0.6884584996953662 1.0027675639880942 0.6743862682035119 0.9977179011704368 0.0056654344063609054 0.08924502743622435 0.06143020715300142 0.005390284019864023 0.02001593024304561 1.1565760452032498e-07 6.936825806969118 -0.3283812957845823 AICIDPAYSK(ub)AYGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AICIDPAYSKAYGR 14 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 253767000.0 72611000.0 113010000.0 68146000.0 True False 99457248.93849325 108016844.52590492 52051318.3109249 1.0 1.0860630640679105 0.5233536908216181 26.56757318988585 -6.867895092357101 1.145243669309803 1.0481017253884024 0.49170047953929097 0.9625330852859679 0.047904159564553364 0.13888526922090189 0.3417813617011963 0.03250353204363225 0.07668061466605859 1.3555168097862118e-07 6.867895092357101 -0.5564012458491114 AICTEAGLMALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AICTEAGLMALR 12 0 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 0 12350600.0 3546200.0 3915300.0 4889100.0 False True 4649102.541449651 3331152.501719864 4383222.831558784 1.0 0.7165151708357818 0.9428105300925536 22.148520815875703 -9.915651968436755 5.900460852277006 1.0000000681014876 0.8296628509830462 0.43034575770596695 0.09238469355682877 8.267228722772457e-08 1.536133958221873e-08 0.08945112955335403 0.02981703163245554 1.214361616387798e-10 9.915651968436755 -0.1703372171184414 AIDLFTDAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIDLFTDAIK 10 0 P50502;Q8NFI4;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 0 23101100.0 3830900.0 9841500.0 9428700.0 False True 5022346.998488367 8373186.561866532 8453108.57047683 1.0 1.6671859918055654 1.6830992707236396 22.259930278479995 -11.272063235722795 0.6132619383777044 6.061390917398883e-06 1.6810323286788589 0.9999480666474888 0.002294042917901647 3.745979548650241 0.3053266910056828 5.102453730196389 0.002722267188495616 5.3448652948160245e-12 11.272063235722795 1.6810262672879415 AIDLFTDAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIDLFTDAIK 10 0 P50502;Q8NFI4;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 0 23389400.0 3830900.0 10905000.0 8653500.0 False True 5247287.256179827 10423181.041987378 6609721.524426791 1.0 1.986394213450351 1.2596454513982247 22.323140340002887 -10.133543978219796 4.5354562734425885 0.9999415503884846 1.6230198322542728 0.49491945027704387 0.2966939398808736 0.00021973538974071231 4.197815441189354e-05 0.2873062680749741 0.09575755731391128 7.352855340500547e-11 10.133543978219796 0.6230782818657882 AIDLFTDAIK(ub)LNPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIDLFTDAIKLNPR 14 1 P50502;Q8NFI4;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 1 5738300.0 1730900.0 1974600.0 2032800.0 True False 2269226.662059442 1679997.3769305162 1822465.3559944981 1.0 0.7403391670913255 0.8031217799726165 21.113769289351232 -9.949442751680154 5.3244271671804615 1.0000005818785986 0.7717304735308613 0.946311847496286 0.025630894383529345 1.7703272040729279e-07 3.497021490930101e-08 0.024817069822367022 0.008272335590756132 1.1234590533065939e-10 9.949442751680154 -0.2282701083477373 AIDLFTDAIK(ub)LNPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIDLFTDAIKLNPR 14 1 P50502;Q8NFI4;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 1 9833000.0 2431000.0 2955600.0 4446400.0 True False 2353829.235662122 4135786.4932503817 3281754.450859256 1.0 1.7570461062299632 1.3942194281294638 21.16657822963272 -10.09438670480869 4.400444650614626 0.9999438546710633 1.575632766691343 0.7704354056391663 0.14812337122527255 22251608.558975697 25522013.549291022 10260.874041116558 0.050706569708178884 8.04661634718271e-11 10.09438670480869 0.5756889120202797 AIDLFTDAIK(ub)LNPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIDLFTDAIKLNPR 14 1 P50502;Q8NFI4;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 1 7006300.0 1730900.0 1520200.0 3755200.0 True False 2370860.5058136904 1453032.5373708594 2868299.10077165 1.0 0.6128713746792842 1.2098135228699323 21.176979350874124 -6.731664299684289 1.717241077691285 0.7674575162810462 1.2095616198730974 0.5669104826621438 0.1627195741005498 0.33313683285455103 1.925359637991587 0.07506882180970664 0.18592259349014492 1.8549649174692786e-07 6.731664299684289 0.4421041035920512 AIDLFTDAIK(ub)LNPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIDLFTDAIKLNPR 14 1 P50502;Q8NFI4;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 1 7768600.0 2431000.0 2741800.0 2595800.0 True False 2021484.2115602319 2727029.379195312 3138569.7783768727 1.0 1.3490233381988785 1.5526066245921586 20.946983505066996 -10.42560241920995 0.09563289800114705 4.835855589187523e-09 2.135589748625917 0.9999253232000318 0.00197191533674365 2.294860562305855 0.051076814179946646 0.8713519454068198 0.3405250496745163 3.753164335556301e-11 10.42560241920995 2.1355897437900615 AIDLFTDAIK(ub)LNPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIDLFTDAIKLNPR 14 1 P50502;Q8NFI4;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 1 12212000.0 2448800.0 4740000.0 5023200.0 True False 3170019.873064525 4476214.83320513 4109029.1423845077 1.0 1.4120463001633736 1.2962155781099955 21.596060454067963 -10.267685392955974 5.436116002247352 0.9999630000846939 1.3541309391366914 0.9257217722797694 0.04728769426155456 2.1208087907924183e-05 2.856991871186154e-06 0.04579088698429699 0.015262037696285875 5.399015907233282e-11 10.267685392955974 0.3541679390519975 AIDSLSIEK(ub)GYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIDSLSIEKGYR 12 1 Q5SYV2;Q9UL12;Q9UL12-2;A0A0A0MT55 Q5SYV2;Q9UL12 SARDH Sarcosine dehydrogenase, mitochondrial 1 27513810.0 854710.0 6742600.0 19916500.0 True False 827577.6988945995 9434955.342194486 14699771.167807296 1.0 11.400688243287384 17.76240610089164 19.658535243211748 -8.273116762810997 0.4099969177954976 2.2780026224548853e-15 19.368958210712286 0.9962224540080608 0.42464685013172015 0.12439443286398329 0.11843409052248231 1.3209682188625165 1.5514176388132768 5.3319152431067e-09 8.273116762810997 19.368958210712282 AIDSLSIEK(ub)GYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIDSLSIEKGYR 12 1 Q5SYV2;Q9UL12;Q9UL12-2;A0A0A0MT55 Q5SYV2;Q9UL12 SARDH Sarcosine dehydrogenase, mitochondrial 1 44756400.0 13678500.0 21548700.0 9529200.0 True False 20751284.532299004 17703166.124238454 7645749.443203265 1.0 0.8531118204602607 0.36844704390722377 24.30669730819009 -6.949293732608529 0.5665442611065514 1.0061348138035304 0.19199942878822837 0.999144687041548 0.007891742558083005 0.08377059183401492 0.03714566414380753 0.008394154805781885 0.04034854851761126 1.1238446109366964e-07 6.949293732608529 -0.814135385015302 down AIDSLSIEK(ub)GYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIDSLSIEKGYR 12 1 Q5SYV2;Q9UL12;Q9UL12-2;A0A0A0MT55 Q5SYV2;Q9UL12 SARDH Sarcosine dehydrogenase, mitochondrial 1 9092310.0 854710.0 5458600.0 2779000.0 True False 710729.2350730748 5429193.438352732 3360076.051355772 1.0 7.638905465587778 4.727645755292873 19.438940518646024 -9.30588216244656 9.135435798117394 1.0000000003870577 6.183275610848374 0.8086689954559705 1.1885167998267039 0.0 0.0 1.1507764431030205 0.38359214770100675 4.944448269942018e-10 9.30588216244656 5.183275610461316 AIDSLSIEK(ub)GYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIDSLSIEKGYR 12 1 Q5SYV2;Q9UL12;Q9UL12-2;A0A0A0MT55 Q5SYV2;Q9UL12 SARDH Sarcosine dehydrogenase, mitochondrial 1 72787300.0 13678500.0 17071100.0 42037700.0 True False 17707087.893545043 16121078.278297044 34387269.943226874 1.0 0.9104308046143396 1.9420059441712287 24.077823630282538 -6.885762685861142 1.0471610526697972 0.9388117526643351 2.0236895990021524 0.9780432151785926 0.06914181079047169 0.1226469082266525 0.24248969098687165 0.05057022581613953 0.12429071136645174 1.300880231640545e-07 6.885762685861142 1.0848778463378173 AIDSSNLK(ub)DDYSTAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIDSSNLKDDYSTAQR 16 1 Q5JVF3-3;Q5JVF3-2;Q5JVF3;Q5JVF3-4 Q5JVF3-3 PCID2 PCI domain-containing protein 2 1 2373600.0 0.0 0.0 2373600.0 True False 0.0 0.0 2128002.6411789376 0.0 AIDSSNLK(ub)DDYSTAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIDSSNLKDDYSTAQR 16 1 Q5JVF3-3;Q5JVF3-2;Q5JVF3;Q5JVF3-4 Q5JVF3-3 PCID2 PCI domain-containing protein 2 1 27797100.0 2964900.0 4847200.0 19985000.0 True False 4497970.063224275 3982179.288653541 16034955.990263347 1.0 0.8853280997159416 3.5649316835979623 22.100842628443104 -6.8969030583536135 0.9806490595235673 0.8789290391267573 3.829151988000703 0.9849612263770331 0.15170091003523253 0.1137205745101043 0.19055927999697994 0.11666507223614758 0.299087201728082 1.2679348581140214e-07 6.8969030583536135 2.9502229488739458 up AIDSSNLK(ub)DDYSTAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIDSSNLKDDYSTAQR 16 1 Q5JVF3-3;Q5JVF3-2;Q5JVF3;Q5JVF3-4 Q5JVF3-3 PCID2 PCI domain-containing protein 2 1 4741300.0 0.0 1077400.0 3663900.0 True False 0.0 1029796.9055146448 2798562.280389129 0.0 AIEDEGGNPDEIEITSEGNKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIEDEGGNPDEIEITSEGNKK 21 1 Q15424-2;Q15424;Q15424-4;Q15424-3;K7ES42 Q15424-2 SAFB Scaffold attachment factor B1 0 11122900.0 3513600.0 1435700.0 6173600.0 False True 3402062.6912474046 2008982.4970765908 4556548.955969931 1.0 0.5905189525887233 1.3393489096167186 21.69797829572183 -6.758255682321785 1.6193530973819457 0.7616319654148732 1.3418215269529339 0.6836877238189629 0.17218668916627927 0.28585549397186255 1.4770373882292367 0.083917471628943 0.20199032024623015 1.744794637010537e-07 6.758255682321785 0.5801895615380607 AIEGFNQSSHQK(ub)NVDAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIEGFNQSSHQKNVDAR 17 1 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 1 10453500.0 3397700.0 5018500.0 2037300.0 True False 4454417.603373602 4269759.361959783 1826499.739161544 1.0 0.9585449192563432 0.4100423224302599 22.086805387008514 -6.922033455677845 0.8095049986892789 1.0112384915842278 0.31731844373357165 0.9947272969960409 0.019523618612199933 0.09699016641633776 0.09952336699972603 0.017005285537700025 0.05197249958571164 1.1966483444956643e-07 6.922033455677845 -0.6939200478506562 down AIEGFNQSSHQK(ub)NVDAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIEGFNQSSHQKNVDAR 17 1 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 1 17528600.0 7237700.0 5258200.0 5032700.0 True False 7007943.175216673 7357826.681150764 3714484.8922362784 1.0 1.0499267041963811 0.5300392425230294 22.740559646037593 -6.883337491979471 1.060962579509282 1.0325561233245164 0.4907460588105636 0.9762812847919295 0.03606857191914864 0.12471689338438617 0.25474417827869994 0.026103365544617285 0.06369810760691265 1.3081649476880614e-07 6.883337491979471 -0.5418100645139527 AIEGFNQSSHQK(ub)NVDAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIEGFNQSSHQKNVDAR 17 1 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 1 9602310.0 3397700.0 4146110.0 2058500.0 True False 4653921.509390014 3962921.1508477125 1572324.6961382725 1.0 0.8515229882695485 0.3378494228933302 22.150015448531406 -6.948210476566218 0.5781588894455895 1.0061834393353226 0.15786220496381073 0.9990532423638376 0.008729152756631938 0.08421244074343823 0.03899877990267223 0.009164190715958545 0.0428887378030287 1.1266513033251328e-07 6.948210476566218 -0.8483212343715119 down AIEGFNQSSHQK(ub)NVDAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIEGFNQSSHQKNVDAR 17 1 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 1 21965300.0 7237700.0 11091500.0 3636100.0 True False 6018468.234475312 11031747.888009617 4396391.698573135 1.0 1.832982655755657 0.7304834930239373 22.52096492147187 -6.704641323186409 1.814317009216682 1.514896993939418 0.7334732777102199 0.43952092853835933 0.3513263074406111 0.38600483108185024 2.473367481701456 0.15429743535948598 0.3945547939419233 1.974052401129802e-07 6.704641323186409 -0.781423716229198 AIEINPDSAQPYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIEINPDSAQPYK 13 0 P50502;Q8NFI4;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 0 18493900.0 4786700.0 2070200.0 11637000.0 False True 4634748.828607111 2896841.6559503833 8588920.597483173 1.0 0.6250266763260558 1.8531577254995317 22.144059726181116 -6.824763992809793 1.351054527071249 0.7988009590171437 1.8828266950426613 0.8950017561139181 0.1665194909773876 0.1873673461748122 0.6706781146676799 0.09681771928140817 0.22292634391234903 1.4970489713752734e-07 6.824763992809793 1.0840257360255177 AIEINPDSAQPYK(ub)WR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIEINPDSAQPYKWR 15 1 P50502;Q8NFI4;Q3KNR6;H7C3I1;F6VDH7 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 6991440.0 992040.0 2096200.0 3903200.0 True False 1300574.0469290246 1783455.1309236016 3499334.3061381998 1.0 1.3712830385434631 2.6906075162740555 20.31071710939415 -6.94759639834879 0.5846358429028051 0.9844882251536645 3.1431800595341723 0.9989989140327687 0.02295349274524097 0.0844654901176191 0.040069108183816794 0.023930329205530697 0.1103533589162505 1.1282454782722317e-07 6.94759639834879 2.158691834380508 up AIEINPDSAQPYK(ub)WR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIEINPDSAQPYKWR 15 1 P50502;Q8NFI4;Q3KNR6;H7C3I1;F6VDH7 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 39251000.0 2184000.0 16300000.0 20767000.0 True False 3313287.671787184 13391137.647518702 16662393.347500538 1.0 4.041646537831571 5.028960657229277 21.659832038255736 -9.319901328386958 0.36756378868798306 4.4090375723355694e-24 5.242267493370626 0.9981943447066237 0.07285884446441461 0.6996137219043725 0.1440803266253275 1.2349110724951513 0.2722854489866593 4.787388493311648e-10 9.319901328386958 5.242267493370626 AIEINPDSAQPYK(ub)WR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIEINPDSAQPYKWR 15 1 P50502;Q8NFI4;Q3KNR6;H7C3I1;F6VDH7 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 8932240.0 992040.0 2112800.0 5827400.0 True False 1358823.9968729636 2019449.5099047145 4451088.139070286 1.0 1.4861744527267962 3.2756914429782613 20.373927170917042 -6.946787028503335 0.5930696942627014 0.9794963277934012 3.872891667241992 0.9989244164167578 0.032091622391148864 0.08480214580674489 0.041503732018581534 0.033166200576265924 0.15005671382999672 1.1303500855024415e-07 6.946787028503335 2.893395339448591 up AIEINPDSAQPYK(ub)WR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIEINPDSAQPYKWR 15 1 P50502;Q8NFI4;Q3KNR6;H7C3I1;F6VDH7 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 27917900.0 2184000.0 16192000.0 9541900.0 True False 2827231.053076167 15290900.96608807 7805372.108161878 1.0 5.408436975623486 2.7607832404320996 21.430958360348185 -9.579788333514468 8.893741293446952 0.9999208632844501 4.084610108027796 0.6440955691799103 1.080900112097805 0.0 0.0 1.0465770328308006 0.34885901094360017 2.631550244604073e-10 9.579788333514468 3.084689244743346 AIEK(ub)MNGMLLNDR ddPTM_RPMI8226_Bortezomib_1h_R1 2 AIEKMNGMLLNDR 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8;H0YEQ8 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 35195800.0 11010000.0 16765300.0 7420500.0 True False 14434216.620991664 14263982.59062757 6652697.842462207 1.0 0.9882062161851913 0.4608977416056786 23.78298947544469 -6.911721707492398 0.8839131344078412 1.0154511768435333 0.3901778760107814 0.9915555109006678 0.02310226671675593 0.10329105188094287 0.13266774226933065 0.019076596245647864 0.0533109770735994 1.22540117522479e-07 6.911721707492398 -0.6252733008327518 down AIEK(ub)MNGMLLNDR ddPTM_RPMI8226_Bortezomib_2h_R1 2 AIEKMNGMLLNDR 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8;H0YEQ8 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 36223220.0 12545900.0 14835220.0 8842100.0 True False 12147637.27177845 20759000.710650284 6526088.752685915 1.0 1.7088920459353745 0.5372311180090478 23.534172399625785 -6.742897908978077 1.6759889969178723 1.4203647649664433 0.5360879217613163 0.6179174557848567 0.2978349454595474 0.3126001430811909 1.7251545070361136 0.14051921550699714 0.3437437597242071 1.8075989942691569e-07 6.742897908978077 -0.884276843205127 AIEK(ub)MNGMLLNDR ddPTM_RPMI8226_Bortezomib_8h_R1 2 AIEKMNGMLLNDR 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8;H0YEQ8 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 62332500.0 25689900.0 6822300.0 29820300.0 True False 38973456.48326261 5604807.262126801 23926304.63429821 1.0 0.14381088483988633 0.6139128215269668 25.21598855132862 -9.577269532631332 10.842087476487926 1.0000084649676089 0.37886144793822535 0.6994941031584863 0.19191831205876458 0.0 0.0 0.18582410658122755 0.06194136886040917 2.646856931590914e-10 9.577269532631332 -0.6211470170293836 AIEK(ub)MNGMLLNDR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AIEKMNGMLLNDR 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8;H0YEQ8 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 33550700.0 11010000.0 16379500.0 6161200.0 True False 15080694.534062479 15655799.530236805 4706051.453897079 1.0 1.0381351797077614 0.3120580052375977 23.846199536967582 -6.894510364484112 0.9953450252261964 1.0349003337129876 0.24380492039797627 0.9836307936558591 0.04268803455949115 0.11555887142139921 0.20109336851334908 0.03246975818505847 0.0823767039132687 1.274939673009424e-07 6.894510364484112 -0.7910954133150113 down AIEK(ub)MNGMLLNDR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AIEKMNGMLLNDR 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8;H0YEQ8 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 32477700.0 12545900.0 15743900.0 4187900.0 True False 10432471.727607368 15659084.485780546 5063570.527338192 1.0 1.5009946726567238 0.48536633115798483 23.31457767506006 -6.772577343846472 1.56461281314754 1.2864096977516368 0.4790920479190682 0.7403156390544573 0.21129787880394024 0.2622805170890963 1.2674862275950831 0.10642630268089426 0.25274200165270844 1.6881951807035897e-07 6.772577343846472 -0.8073176498325687 down AIEK(ub)MNGMLLNDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIEKMNGMLLNDR 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8;H0YEQ8 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 18644900.0 5971900.0 7709600.0 4963400.0 True False 7730742.273747964 7280553.982716933 4060112.1287846905 1.0 0.9417664856633781 0.5251904649016705 22.88217551170755 -6.932239072537469 0.728185918495774 1.005838570603325 0.4345821715625325 0.9969601266209129 0.01165788259183426 0.09149211677346286 0.07210813105931219 0.010765944385770101 0.03723984355021881 1.1688557764765421e-07 6.932239072537469 -0.5712563990407926 AIEK(ub)MNGMLLNDRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIEKMNGMLLNDRK 14 2 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8;H0YEQ8 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 13050600.0 3456900.0 5822400.0 3771300.0 True False 4475025.195686354 5498378.321699059 3084962.0968057592 1.0 1.228680975248844 0.68937312348084 22.093464374514348 -6.791506566587265 1.4903552314520392 1.1275607393467468 0.6834011119319036 0.8061468371005882 0.09731108391777778 0.2331178339359567 1.0228828285040514 0.05138994354477216 0.12018329858935264 1.6161937888682212e-07 6.791506566587265 -0.44415962741484327 AIEK(ub)NVLFSHLDDNER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIEKNVLFSHLDDNER 16 1 P10644;P10644-2;K7EPB2;K7EIE5;K7EID3;K7EJ40;K7EK41 P10644 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 1 4880500.0 1482300.0 1840800.0 1557400.0 True False 1232598.1270241588 1830883.2450298085 1883045.1393960011 1.0 1.485385386273529 1.5277040408476084 20.23327107331957 -11.692888875384098 0.3971941369271826 1.797209330693708e-11 1.5307940807654778 0.9996869110392999 0.004236222223958707 4.530487620832032 0.20098775024772203 3.843678884454145 0.01090288252165973 2.02820161695765e-12 11.692888875384098 1.5307940807475058 AIELFSVGQGPAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIELFSVGQGPAK 13 0 P30419;P30419-2;B7Z8J4;K7EN82 P30419 NMT1 Glycylpeptide N-tetradecanoyltransferase 1 0 10209000.0 3543800.0 2792000.0 3873200.0 False True 4645956.118208018 2375444.483130758 3472438.418357873 1.0 0.5112929228541628 0.7474109375999056 22.1475440970519 -10.09030460426663 5.110348045073955 1.0000083195833303 0.629351930226131 0.7666560304239831 0.09639477587081637 9.137327880792755e-06 1.6264430190115477e-06 0.09333593472426618 0.03111128013363745 8.122606152182955e-11 10.09030460426663 -0.37065638935719925 AIELFSVGQGPAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIELFSVGQGPAK 13 0 P30419;P30419-2;B7Z8J4;K7EN82 P30419 NMT1 Glycylpeptide N-tetradecanoyltransferase 1 0 11160600.0 3543800.0 2987700.0 4629100.0 False True 4854038.627594062 2855693.534997313 3535801.9193071094 1.0 0.5883128986167044 0.7284247593760197 22.21075415857479 -10.39919830541223 5.204868613752158 1.0002549550427775 0.6583688289963491 0.8879791511426315 0.05720042762874668 0.0001693535393370205 1.954864168428266e-05 0.055424885348073154 0.01846135863350001 3.9884274316349294e-11 10.39919830541223 -0.34188612604642843 AIELLQEFSDQHPENAAEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIELLQEFSDQHPENAAEIK 20 0 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 0 7459500.0 1150000.0 3690700.0 2618800.0 False True 1507661.1366158414 3140061.94623592 2347831.6973034185 1.0 2.0827372079671913 1.55726750546443 20.523880772824697 -10.221643866523653 4.477700369184471 0.9997416509087645 1.8200023567261312 0.764536063458696 0.21452210785145961 0.0005746875768501198 9.989686410677768e-05 0.2077764522758446 0.06923671257503103 6.002831232310027e-11 10.221643866523653 0.8202607058173667 AIELLQEFSDQHPENAAEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIELLQEFSDQHPENAAEIK 20 0 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 0 6935400.0 1150000.0 2864100.0 2921300.0 False True 1575186.0775814578 2737554.591687854 2231349.1060620546 1.0 1.7379245732612734 1.4165622321193125 20.58709083434759 -10.089396896572874 4.488957413722326 0.9999593200056323 1.5772434023219293 0.8113906306247386 0.13119562654265537 20156962.535054676 22652435.85061966 7587.836787567888 0.04491175423191992 8.139600755578913e-11 10.089396896572874 0.577284082316297 AIELNPANAVYFCNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIELNPANAVYFCNR 15 0 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 0 15322000.0 4956300.0 4901400.0 5464300.0 False True 6497757.296877479 4170130.225507562 4898906.653266789 1.0 0.641779930363286 0.7539380788539112 22.63151042669879 -10.644481911403256 9.66508803605842 1.0001106868507041 0.6978590046085988 0.9063320609135678 0.045788372382889846 0.00010924851613132467 4.01856614062761e-06 0.0443503729903854 0.014778133640739667 2.2673475114113786e-11 10.644481911403256 -0.3022516822421053 AIELNPANAVYFCNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIELNPANAVYFCNR 15 0 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 0 9312700.0 4524500.0 1873800.0 2914400.0 False True 4380872.224086092 2622018.1117379144 2151031.209874103 1.0 0.5985150850376382 0.49100523819154224 22.06278670583721 -13.999999999999977 0.18493041827006093 3.1158607322706704 0.4098150069117675 0.9994930126907181 0.004932084020018866 12.272516287562302 0.13635815200191134 9.342272596888714 0.07702959100233243 1.0000000000000532e-14 13.999999999999977 -2.7060457253589028 AIELNPANAVYFCNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIELNPANAVYFCNR 15 0 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 0 19219900.0 4956300.0 6834000.0 7429600.0 False True 6788778.048971293 6532051.282984112 5674881.497415067 1.0 0.9621836560077137 0.8359209060126785 22.69472048822168 -6.949023664820541 0.5694637028982237 1.001576661365823 0.7903947744535198 0.9991223976508044 0.002078260173432736 0.08388021408587647 0.03760360370336181 0.0022031384526888043 0.010518780680134787 1.1245436956156683e-07 6.949023664820541 -0.21118188691230322 AIELQLQVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIELQLQVK 9 0 Q9H6T3-2;Q9H6T3 Q9H6T3-2 RPAP3 RNA polymerase II-associated protein 3 0 32464700.0 5847700.0 14948000.0 11669000.0 False True 8871388.424134579 12280412.61074292 9362617.035295613 1.0 1.3842717761443184 1.0553722357398587 23.080728481726403 -10.377545161269921 6.284526636712246 0.9999730699504827 1.2198220059420886 0.37327642784538484 0.134272675104471 5.067018906168638e-05 5.018510454223586e-06 0.13002486523027118 0.043336319544194604 4.192323994187506e-11 10.377545161269921 0.21984893599160582 AIELQLQVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIELQLQVK 9 0 Q9H6T3-2;Q9H6T3 Q9H6T3-2 RPAP3 RNA polymerase II-associated protein 3 0 20325400.0 5847700.0 7956800.0 6520900.0 False True 7569962.925399956 7513997.085410675 5334163.1100842375 1.0 0.9926068541496424 0.7046485118422702 22.851854803818853 -6.912411817143339 0.8791355840591671 1.0082501838155296 0.6654472078251515 0.9918006376459331 0.012452531828690855 0.10284507565820222 0.13027094357652153 0.010318211924263949 0.02898270416053569 1.2234555146761437e-07 6.912411817143339 -0.342802975990378 AIELSLQEQK(ub)QQHTETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIELSLQEQKQQHTETK 17 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 15560800.0 3980900.0 4645900.0 6934000.0 True False 3854528.5085344915 6501032.098048436 5117777.3844589135 1.0 1.6865959309041814 1.3277311020342446 21.878122967726465 -10.033446740478476 4.293799209655674 0.9999650902697803 1.5071635161015 0.7270005412723658 0.146505953279344 102109681.14500636 260359053.82736763 56842.38762437276 0.053615667377153446 9.258769226867091e-11 10.033446740478476 0.5071984258317197 AIELSLQEQK(ub)QQHTETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIELSLQEQKQQHTETK 17 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 48380500.0 2701100.0 19173800.0 26505600.0 True False 4097766.176860976 15752085.584416848 21266756.54218284 1.0 3.8440664753798774 5.1898413975572115 21.96640623422304 -8.87353216105452 0.3126491385619665 7.4538982076439685e-19 5.760509537014518 0.9984851370921265 0.06797871203617042 0.37883628288165383 0.10416848600243132 0.8913820715446357 0.4337855461731491 1.3380361251402996e-09 8.87353216105452 5.760509537014518 AIELSLQEQK(ub)QQHTETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIELSLQEQKQQHTETK 17 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 8142560.0 3814900.0 611130.0 3716530.0 True False 5225371.6237960905 584128.2558633423 2838762.1583380043 1.0 0.11178693075211156 0.5432651230795563 22.317102213358336 -10.396075267862837 5.2570931261915 1.0004495592333407 0.32752602747598114 0.7640791380029351 0.17615023439018682 0.0009287412952426095 0.00010669184221817222 0.17066563431465517 0.056852243685300514 4.017211822526145e-11 10.396075267862837 -0.6729235317573595 AIELSLQEQK(ub)QQHTETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIELSLQEQKQQHTETK 17 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 14660600.0 3980900.0 7241700.0 3438000.0 True False 3310294.733772165 7202687.524735097 4156869.9044840387 1.0 2.1758447824153264 1.255740119474854 21.65852824316074 -10.44456407053794 5.166015841505195 0.9990330673536592 1.7157924509451057 0.4465766319365232 0.37563115569334554 0.004188355636536793 0.000450320839444844 0.3641459187884167 0.12123443419307117 3.592823886814665e-11 10.44456407053794 0.7167593835914465 AIELSLQEQK(ub)QQHTETK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIELSLQEQKQQHTETK 17 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 30243000.0 2701100.0 19113600.0 8428300.0 True False 3496627.1966410447 18049911.357795283 6894435.881660961 1.0 5.162092022602387 1.9717389055041221 21.73753255631549 -6.578739693951446 2.2709346781812814 3.8362273113206484 1.9792101364796215 0.0 1.8086583551073177 0.7030415046269373 6.817222303601342 0.6691240071192901 2.0234168167435795 2.637912015415433e-07 6.578739693951446 -1.857017174841027 AIEMFMNK(ub)NPPAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIEMFMNKNPPAR 13 1 Q13895;H7BY94;F8WBL2 Q13895 BYSL Bystin 1 35591100.0 3143100.0 15468000.0 16980000.0 True False 4768312.491389327 12707614.547964377 13623895.557401627 1.0 2.6650129518381886 2.8571733882801964 22.185047355251097 -10.400247209766874 0.44858598697989843 3.4883757395009714e-23 2.8614699292809838 0.9993857882706001 0.020666432343941925 1.7952719242172657 0.21052920161669544 2.1687938683750767 0.043333384436838394 3.978806238668827e-11 10.400247209766874 2.8614699292809838 AIEQAK(ub)TQNINK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIEQAKTQNINK 12 1 O60930 O60930 RNASEH1 Ribonuclease H1 1 8531370.0 630850.0 605720.0 7294800.0 True False 816647.7609125909 572011.1495293276 5967221.250968813 1.0 0.7004380308226331 7.30697068746082 19.639354419194092 -6.89627673782387 0.9844767245108611 0.6965674473513307 7.950374830607797 0.9846220491780642 0.37775249079980117 0.11419912422032824 0.19326517811640131 0.28967125059950355 0.7405600447877736 1.2697647375458815e-07 6.89627673782387 7.253807383256466 up AIETQCYVVAAAQCGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIETQCYVVAAAQCGR 16 0 Q86X76-2;Q86X76-4;Q86X76;Q86X76-3 Q86X76-2 NIT1 Nitrilase homolog 1 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 AIFEIVLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIFEIVLNR 9 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 2637950.0 804940.0 1126300.0 706710.0 False True 1055284.1350500472 958260.4302830151 633586.428441004 1.0 0.9080591647836811 0.6003941567935691 20.009200065922247 -6.948972115694295 0.57001539758664 1.003832282603256 0.4896621654819756 0.9991181394579709 0.00507443332856355 0.08390110875180366 0.03769075152865749 0.005375957069398383 0.025634640136974297 1.1246771826569549e-07 6.948972115694295 -0.5141701171212804 AIFEIVLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIFEIVLNR 9 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 5092300.0 3317300.0 1775000.0 0.0 False True 3211994.127298214 2483766.7565027173 0.0 1.0 0.7732787352858428 0.0 21.615037824406834 -7.2939822374756185 0.8225200255463543 0.988984850714435 3.1170919237781988e-18 0.988347890420058 0.04621033156536639 0.10325487982273451 0.1375131954629574 0.03937022466765317 0.06962855177030633 5.0818022656646264e-08 7.2939822374756185 -0.988984850714435 down AIFEIVLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIFEIVLNR 9 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 26426500.0 7499700.0 9944800.0 8982000.0 False True 11377593.201512074 8170072.740922961 7206703.763049554 1.0 0.7180844486369194 0.6334119734648087 23.43969206865067 -13.999999999999998 0.16854760411652547 2.416383789049455 0.5575544975065249 0.9995165240471835 0.003445829055508937 12.077720064646142 0.12997674495353284 5.592371704451585 0.06995604174091176 1.0000000000000041e-14 13.999999999999998 -1.8588292915429299 AIFEIVLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIFEIVLNR 9 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 4950140.0 804940.0 1662900.0 2482300.0 False True 1102548.0706855806 1589427.579525063 1896031.8645732482 1.0 1.441594812765609 1.7196818125075197 20.07241012744514 -9.083116160023513 0.10049440880299909 1.1573917334696557e-18 2.5592263091788245 0.999960670010229 0.001858356948165838 0.5539327507644238 0.033823513475898404 0.4923479742332401 0.34042097876058836 8.25817040123691e-10 9.083116160023513 2.5592263091788245 AIFEIVLNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIFEIVLNR 9 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 7569200.0 3317300.0 1585300.0 2666600.0 False True 2758481.931307593 1576759.674242586 3224173.731034658 1.0 0.5716041335442644 1.168821769119334 21.39544309984111 -6.714184661641977 1.780328220507613 0.7377613131160007 1.1675954578505783 0.48490152244786866 0.18041087371444048 0.3667422578095143 2.268416095077979 0.08056596053936818 0.20364046558612844 1.93114702036186e-07 6.714184661641977 0.4298341447345776 AIFEIVLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIFEIVLNR 9 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 18828900.0 7499700.0 6407600.0 4921600.0 False True 9708509.491188347 6051011.427266918 4025919.299880476 1.0 0.6232688377921396 0.41467944214655067 23.210818390743118 -10.148559319326411 0.12385331536959278 1.783942056880789 8.46889613732455e-21 0.9998473751095421 0.0029924190485865945 1.7958946224026837 0.05997277969329607 0.677578284536375 0.2364073372248729 7.102981453182287e-11 10.148559319326411 -1.783942056880789 AIFK(ub)GSPCSEEAGTLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIFKGSPCSEEAGTLR 16 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BT54;H3BMG4;Q9NVI1-4;H3BQE2;H3BS60 Q9NVI1 FANCI Fanconi anemia group I protein 1 7602500.0 1455100.0 2415600.0 3731800.0 True False 1907650.1912084427 2055201.8959350514 3345669.1339533 1.0 1.0773473592834852 1.7538168944034298 20.86336521567974 -6.928475414678322 0.759194710939441 0.9891107757952814 1.8874538529322422 0.996230271952995 0.020789237594540252 0.09343667307108607 0.08161278088263342 0.01877119122025429 0.061729612685526486 1.1790292659599064e-07 6.928475414678322 0.8983430771369608 AIFK(ub)GSPCSEEAGTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIFKGSPCSEEAGTLR 16 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BT54;H3BMG4;Q9NVI1-4;H3BQE2;H3BS60 Q9NVI1 FANCI Fanconi anemia group I protein 1 10664400.0 1455100.0 2382400.0 6826900.0 True False 1993089.7925989367 2277137.6904567354 5214526.824418931 1.0 1.1425163577238573 2.6163030104224885 20.92657527720263 -6.925652823393545 0.7816379220332645 0.9736141446163362 2.887899458625492 0.9956129880698965 0.048395001815519575 0.09495849520198776 0.08920067152605098 0.04299915791591434 0.13667772272139495 1.1867170350479954e-07 6.925652823393545 1.9142853140091556 up AIFLFVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIFLFVDK 8 0 H3BQ50;P60520;H3BSM5 H3BQ50 GABARAPL2 Gamma-aminobutyric acid receptor-associated protein-like 2 0 7097200.0 1846900.0 2173200.0 3077100.0 False True 2421303.7854050407 1848967.0310672505 2758711.209627446 1.0 0.7636245572374354 1.1393494803321274 21.207352665679924 -6.736644672784272 1.6988229282693952 0.8588119136660285 1.1394181282107867 0.5898027157246813 0.09932642636856565 0.3239473115157693 1.8343305238178291 0.04627730891384291 0.1139882315337473 1.833814182616074e-07 6.736644672784272 0.2806062145447582 AIFLFVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIFLFVDK 8 0 H3BQ50;P60520;H3BSM5 H3BQ50 GABARAPL2 Gamma-aminobutyric acid receptor-associated protein-like 2 0 7044600.0 2475300.0 1508400.0 3060900.0 False True 2396722.95641072 2110711.986202085 2259158.464968311 1.0 0.8806658193665575 0.9426030901592304 21.19263172298704 -10.118874178224804 4.4523018589415235 1.0000094612417536 0.911634454817942 0.7307442891584159 0.025285784938200582 2.6482185871268263e-06 5.24092414661335e-07 0.024485778803632306 0.008160951993748168 7.605465870410803e-11 10.118874178224804 -0.08837500642381158 AIFLFVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIFLFVDK 8 0 H3BQ50;P60520;H3BSM5 H3BQ50 GABARAPL2 Gamma-aminobutyric acid receptor-associated protein-like 2 0 13507200.0 2965700.0 5496900.0 5044600.0 False True 4499183.721712111 4515935.2475242745 4047532.5988732777 1.0 1.0037232366687594 0.899614874436165 22.101231849108707 -6.898606379914451 0.970048831863657 1.004495509664466 0.8889915122156492 0.9858597318863903 0.0057343959878198405 0.11243793037361163 0.18326731767133103 0.004445043149370539 0.01148630475253451 1.2629717025056224e-07 6.898606379914451 -0.1155039974488169 AIFLFVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIFLFVDK 8 0 H3BQ50;P60520;H3BSM5 H3BQ50 GABARAPL2 Gamma-aminobutyric acid receptor-associated protein-like 2 0 9234800.0 1846900.0 3290700.0 4097200.0 False True 2529748.8405958205 3145305.993110302 3129525.7444827436 1.0 1.243327378052875 1.237089506381851 21.270562727202815 -10.027944529155908 4.479783958777429 0.9999894445570432 1.2402084422403543 0.9994944777671694 0.0025466005267564904 390642.6996899336 437224.57935263455 32.389543007680594 0.0008717690977443478 9.376817659363578e-11 10.027944529155908 0.24021899768331112 AIFLFVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIFLFVDK 8 0 H3BQ50;P60520;H3BSM5 H3BQ50 GABARAPL2 Gamma-aminobutyric acid receptor-associated protein-like 2 0 4714200.0 2475300.0 1232200.0 1006700.0 False True 2058321.6243829906 1225561.8940274513 1217196.3155451093 1.0 0.5954180724282241 0.5913538006529859 20.973036998421318 AIFLFVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIFLFVDK 8 0 H3BQ50;P60520;H3BSM5 H3BQ50 GABARAPL2 Gamma-aminobutyric acid receptor-associated protein-like 2 0 11967600.0 2965700.0 5520200.0 3481700.0 False True 3839157.1126868064 5212996.017354208 2848066.32525883 1.0 1.3578490966486991 0.7418467756495726 21.872358171201157 -6.749221507574127 1.6527273095133788 1.210618275143066 0.7406959474345507 0.6455892848642728 0.1503653771422308 0.30141754220118194 1.6196504604614428 0.07187772819176741 0.17464246299130937 1.7814699147088516e-07 6.749221507574127 -0.4699223277085154 AIFMLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIFMLR 6 0 Q14696 Q14696 MESDC2 LDLR chaperone MESD 0 11274400.0 3090400.0 2990300.0 5193700.0 False True 4051544.3274761727 2544158.896098103 4656305.745488301 1.0 0.6279479355179448 1.1492668891491191 21.95004049433753 -6.715079364764682 1.7768734242724549 0.772467064740552 1.1482460959474916 0.48924634381299137 0.15666280270281535 0.364978431365357 2.249217430982311 0.07007892500267514 0.176960480331839 1.9271727015223473e-07 6.715079364764682 0.37577903120693956 AIFMLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIFMLR 6 0 Q14696 Q14696 MESDC2 LDLR chaperone MESD 0 9886000.0 3090400.0 2419400.0 4376200.0 False True 4233004.394919774 2312502.9081140975 3342631.6906681163 1.0 0.5463029783029378 0.7896593952701219 22.01325055586042 -10.055291072668107 5.131211791505739 1.0000047169481827 0.6679811867854234 0.7127977658801057 0.09934984120411831 5.361166788256044e-06 9.869814018557131e-07 0.09619643729246682 0.03206502336877147 8.8045857463347e-11 10.055291072668107 -0.3320235301627593 AIFSVYVVNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIFSVYVVNK 10 0 Q9Y296;E9PKS9;E9PQE8;J3KP27;Q9Y296-2;E9PN70;G3V1A0;G5EA23 Q9Y296 TRAPPC4 Trafficking protein particle complex subunit 4 0 7491100.0 1737800.0 2734200.0 3019100.0 False True 2278272.6288791397 2326268.0178281236 2706712.493252157 1.0 1.0210665696197196 1.1880546950097892 21.119508966413093 -6.930266433981173 0.744592321481314 0.9974856642997223 1.2225713745127251 0.9965905564560629 0.004912102532664199 0.09249941507072534 0.07700138264432961 0.004482302146837448 0.015087427521524107 1.1741769917157401e-07 6.930266433981173 0.22508571021300283 AIFSVYVVNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIFSVYVVNK 10 0 Q9Y296;E9PKS9;E9PQE8;J3KP27;Q9Y296-2;E9PN70;G3V1A0;G5EA23 Q9Y296 TRAPPC4 Trafficking protein particle complex subunit 4 0 13411900.0 4602900.0 3096400.0 5712600.0 False True 4456783.459000076 4332808.667512687 4216298.685673482 1.0 0.972182899925947 0.9460407319451528 22.0875714359925 -6.971878289117759 0.20858866560612624 1.01393582181864 0.9035592518948486 0.9999934814721149 5.595453480035457e-05 0.07569831932752648 0.00680785080163121 0.0007916797343192922 0.0027178640499405326 1.0668950763229745e-07 6.971878289117759 -0.11037656992379141 AIFSVYVVNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIFSVYVVNK 10 0 Q9Y296;E9PKS9;E9PQE8;J3KP27;Q9Y296-2;E9PN70;G3V1A0;G5EA23 Q9Y296 TRAPPC4 Trafficking protein particle complex subunit 4 0 35971000.0 10905000.0 10453000.0 14613000.0 False True 16543682.262289042 8587580.480338223 11724734.14489456 1.0 0.5190851918084418 0.7087136925750099 23.979777046863997 -10.161502233175137 5.2918703359777215 1.0000141084391687 0.6138994421915618 0.8468030723466107 0.07741551126175121 1.2886451443349647e-05 2.0418199940240176e-06 0.07495998302094564 0.024985748821158366 6.894420479985515e-11 10.161502233175137 -0.38611466624760693 AIFSVYVVNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIFSVYVVNK 10 0 Q9Y296;E9PKS9;E9PQE8;J3KP27;Q9Y296-2;E9PN70;G3V1A0;G5EA23 Q9Y296 TRAPPC4 Trafficking protein particle complex subunit 4 0 8827000.0 1737800.0 2763500.0 4325700.0 False True 2380311.6222791816 2641399.4323275657 3304058.750587965 1.0 1.109686398875114 1.388078232977026 21.182719027935985 -6.955137081013079 0.4992759370316432 0.9943895153811291 1.5153675644573639 0.9995451753600749 0.0034836172795891475 0.08148623721445795 0.02791567329184756 0.004090968209270102 0.022964257837925696 1.108824769797546e-07 6.955137081013079 0.5209780490762348 AIFSVYVVNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIFSVYVVNK 10 0 Q9Y296;E9PKS9;E9PQE8;J3KP27;Q9Y296-2;E9PN70;G3V1A0;G5EA23 Q9Y296 TRAPPC4 Trafficking protein particle complex subunit 4 0 8576500.0 4602900.0 1675200.0 2298400.0 False True 3827515.2930442593 1666175.365098836 2778984.8133991035 1.0 0.4353151424703058 0.7260545290176503 21.867976711426778 -10.003150603478216 5.075650086607273 1.0000036549533893 0.5806848357406388 0.73498684485925 0.11869385754011166 4.909171298214266e-06 9.642998865358492e-07 0.11492583499062968 0.03830827779416051 9.92771718001787e-11 10.003150603478216 -0.4193188192127505 AIFSVYVVNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIFSVYVVNK 10 0 Q9Y296;E9PKS9;E9PQE8;J3KP27;Q9Y296-2;E9PN70;G3V1A0;G5EA23 Q9Y296 TRAPPC4 Trafficking protein particle complex subunit 4 0 39822000.0 10905000.0 17574000.0 11343000.0 False True 14116737.46968664 16595991.451212447 9278690.389008498 1.0 1.1756251390839842 0.6572829174540471 23.750903368956447 -6.815322436207857 1.3922880318543354 1.0951298814672579 0.6470896104096091 0.8732109527415476 0.07664363688217077 0.19963550268363697 0.7616764979820476 0.04327493424504643 0.09987309916244663 1.5299511478705988e-07 6.815322436207857 -0.44804027105764876 AIFTGHSAVVEDVAWHLLHESLFGSVADDQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIFTGHSAVVEDVAWHLLHESLFGSVADDQK 31 0 Q16576;E9PC52;Q16576-2;Q5JP02;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 0 1439870000.0 468070000.0 445550000.0 526250000.0 False True 710096410.5006534 366038121.4019609 422236456.8364312 1.0 0.5154766535770625 0.5946184920702999 29.403439673164804 -10.742188324458477 6.947491931808983 1.007197290120945 0.5550475728239 0.9768227371193055 0.032309520269031326 0.003612243952452987 0.00013404515911831613 0.03137355639482543 0.010427852827159108 1.8105548058923295e-11 10.742188324458477 -0.4521497172970449 AIFTGHSAVVEDVAWHLLHESLFGSVADDQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIFTGHSAVVEDVAWHLLHESLFGSVADDQK 31 0 Q16576;E9PC52;Q16576-2;Q5JP02;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 0 1032980000.0 468070000.0 327120000.0 237790000.0 False True 605925842.0390848 308915484.43840927 194514659.93144032 1.0 0.5098239140929113 0.32102057122510597 29.174565995257254 -13.999999999999096 0.13210219244487262 3.33048323207216 0.06354021908287755 0.9996362053791884 0.005457835645194163 11.934043062679706 0.11322951299764555 7.208358325977754 0.22917918771731258 1.000000000002082e-14 13.999999999999096 -3.266943012989282 AIFTTGQGASAVGLTAYVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIFTTGQGASAVGLTAYVQR 20 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 32780700.0 11762000.0 5898700.0 15120000.0 False True 11388621.748193305 8254081.671314137 11159618.409722917 1.0 0.7247656348428261 0.9798919181325241 23.441089826765925 -10.461583082193005 8.103924082408563 1.0000063974374682 0.8523287766077249 0.308773714356518 0.10415486900541843 1.2039283727687506e-05 8.000326789454849e-07 0.10085188547946708 0.03361583942370005 3.454752325243518e-11 10.461583082193005 -0.14767762082974334 AIFTTGQGASAVGLTAYVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIFTTGQGASAVGLTAYVQR 20 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 104982000.0 17821000.0 50263000.0 36898000.0 False True 27035759.8896151 41293174.94338853 29605094.127032068 1.0 1.5273539605317308 1.0950346595733709 24.688365570791337 -13.565793776966597 11.98756069838424 1.0524352936542005 1.280074707630101 0.0 0.24071330814512637 0.0 0.0 0.0 0.06612821360883886 2.7177294656825796e-14 13.565793776966597 0.22763941397590037 AIFTTGQGASAVGLTAYVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIFTTGQGASAVGLTAYVQR 20 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 8880800.0 2257200.0 2083100.0 4540500.0 False True 3091747.8385364045 1991061.7541094813 3468127.4145328305 1.0 0.6439922846528213 1.12173682837427 21.55999122787284 -6.707153968827265 1.8050218056929443 0.7805094558696378 1.120540361304388 0.45177175682855075 0.1500871823940056 0.38080086923974465 2.4166233237600565 0.06621019015970167 0.1688087362613726 1.9626643373013443e-07 6.707153968827265 0.34003090543475023 AIFTTGQGASAVGLTAYVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIFTTGQGASAVGLTAYVQR 20 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 26017500.0 11762000.0 4459200.0 9796300.0 False True 9780624.144949192 4435177.404518103 11844661.037026467 1.0 0.45346568263830805 1.2110332491554912 23.2214951022002 -6.71315222149132 1.7841400612372427 0.6650885728150803 1.209411277028542 0.480001817392369 0.23019627043999577 0.36876429801503113 2.290115129448512 0.10260585689744785 0.25965883470130874 1.9357433612945198e-07 6.71315222149132 0.5443227042134616 AIFTTGQGASAVGLTAYVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIFTTGQGASAVGLTAYVQR 20 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 83260000.0 17821000.0 38820000.0 26619000.0 False True 23069635.804427814 36659632.874477476 21774615.134004846 1.0 1.5890858956447549 0.9438647111119799 24.459491892883786 -6.666485324344185 1.9497398775689343 1.3771432366028367 0.9465060353577842 0.2635682704345619 0.25043583039459766 0.46926733486994937 3.4357159109761506 0.10352909210478897 0.27788704504419864 2.1553344752824554e-07 6.666485324344185 -0.43063720124505245 AIGFVMVDAKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIGFVMVDAKK 11 1 O14958-2;O14958 O14958-2 CASQ2 Calsequestrin-2 0 4478300.0 4478300.0 0.0 0.0 False True 5871094.667918893 0.0 0.0 1.0 0.0 0.0 22.48519808879935 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 AIGFVMVDAKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIGFVMVDAKK 11 1 O14958-2;O14958 O14958-2 CASQ2 Calsequestrin-2 0 4478300.0 4478300.0 0.0 0.0 False True 6134048.531506997 0.0 0.0 1.0 0.0 0.0 22.548408150322242 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 AIGISNFNHLQVEMILNKPGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIGISNFNHLQVEMILNKPGLK 22 1 P15121;E9PCX2 P15121 AKR1B1 Aldose reductase 0 26714900.0 12494000.0 6747900.0 7473000.0 False True 12097384.808869824 9442371.65983363 5515597.11480551 1.0 0.7805299913176662 0.4559330137833976 23.528191866169504 -6.965490693826434 0.34953308172693487 1.0315373918897304 0.19398048028052073 0.9999229004387561 0.001962395719520331 0.07779488997055306 0.014275339434748822 0.004460914354643376 0.027908652087466863 1.0827029153145405e-07 6.965490693826434 -0.8375569116092096 down AIGISNFNHLQVEMILNKPGLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 AIGISNFNHLQVEMILNKPGLK 22 1 P15121;E9PCX2 P15121 AKR1B1 Aldose reductase 0 475255000.0 120874000.0 169984000.0 184397000.0 False True 183374695.0730786 139649027.10894617 147950852.12592372 1.0 0.7615501531075111 0.8068226211199002 27.45021932599594 -10.496114155218935 6.1616224325122575 1.0001695604305245 0.7841863871137069 0.9680500781096582 0.01848240767113784 4.30842486023084e-05 3.523334890588066e-06 0.01790947052954239 0.005965171425677747 3.190699062900039e-11 10.496114155218935 -0.2159831733168176 AIGISNFNHLQVEMILNKPGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIGISNFNHLQVEMILNKPGLK 22 1 P15121;E9PCX2 P15121 AKR1B1 Aldose reductase 0 27359700.0 12494000.0 6485600.0 8380100.0 False True 10389314.578047523 6450660.785509187 10132340.16479544 1.0 0.6208937786078152 0.9752655084874351 23.30859714160378 -10.516476445943274 8.90737808640624 1.0000099598544596 0.7980796444196281 0.3021113018876682 0.14467165291207665 2.861604124423272e-05 1.5533332239100888e-06 0.14008462905906438 0.04669257519973101 3.0445531075521823e-11 10.516476445943274 -0.20193031543483153 AIGISNFNHLQVEMILNKPGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AIGISNFNHLQVEMILNKPGLK 22 1 P15121;E9PCX2 P15121 AKR1B1 Aldose reductase 0 383816600.0 120874000.0 177927000.0 85015600.0 False True 156473775.78275102 168025206.0395969 69543633.13372044 1.0 1.073823426315755 0.4444427367195074 27.221345648088388 -6.877654931756263 1.0927455759466203 1.044483196187873 0.4017887343127589 0.9717463114688741 0.04721835785647285 0.1297299533485708 0.28498378138198605 0.03335231157709671 0.08019846411534069 1.325394207573801e-07 6.877654931756263 -0.6426944618751143 down AIGPHDVLATLLNNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIGPHDVLATLLNNLK 16 0 O75533;H7C341 O75533 SF3B1 Splicing factor 3B subunit 1 0 353260000.0 142930000.0 0.0 210330000.0 False True 138392765.38592663 0.0 155238263.23525274 1.0 0.0 1.121722387744404 27.044193285782693 -10.685424468282148 4.345645672459535 1.0188611354755537 0.5608611938808614 0.16967560045892116 0.45794124717209533 0.08426751120625987 0.006100008960947869 0.44650037976200846 0.14779990198652587 2.0633624924129488e-11 10.685424468282148 -0.45799994159469226 AIGPHDVLATLLNNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIGPHDVLATLLNNLK 16 0 O75533;H7C341 O75533 SF3B1 Splicing factor 3B subunit 1 0 419991000.0 142930000.0 88231000.0 188830000.0 False True 118852627.87260568 87755682.09051777 228313479.94872662 1.0 0.7383571037619823 1.920979653840288 26.82459856121697 -6.8486752670861994 1.2414321767550585 0.8605190564953276 1.9670712052743418 0.9383620756127045 0.1259222036899557 0.15891826883457083 0.47196610408086015 0.07939710413128538 0.18358476181755853 1.4168528004757662e-07 6.8486752670861994 1.1065521487790142 AIGPHDVLATLLNNLK(ub)VQER ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIGPHDVLATLLNNLKVQER 20 1 O75533;H7C341 O75533 SF3B1 Splicing factor 3B subunit 1 1 32587400.0 9388600.0 8703800.0 14495000.0 True False 14243192.598599445 7150538.886900216 11630056.896615822 1.0 0.5020320295046309 0.8165344122187481 23.763769225538255 -10.334801374860879 6.589168309183969 1.00001410223091 0.6592832208616917 0.6101164916159219 0.12839506008985 2.6600307134176184e-05 2.6853954306830057e-06 0.12432312296452667 0.041439327455274115 4.62592540318833e-11 10.334801374860879 -0.34073088136921825 AIGPHDVLATLLNNLK(ub)VQER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIGPHDVLATLLNNLKVQER 20 1 O75533;H7C341 O75533 SF3B1 Splicing factor 3B subunit 1 1 23713500.0 9388600.0 8286300.0 6038600.0 True False 12153727.776973868 7825160.120756893 4939636.761268339 1.0 0.6438485594174846 0.4064297680442411 23.534895547630704 -8.281429837201875 0.16109959262235318 1.364423370631707 3.0970233043057513e-18 0.9998992281944169 0.0024487354045314067 0.08969590052071753 0.03451099319472317 0.12815695281900327 0.1292134567511484 5.230824663693676e-09 8.281429837201875 -1.364423370631707 down AIGSASEGAQSSLQEVYHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIGSASEGAQSSLQEVYHK 19 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 24117100.0 7151800.0 3711300.0 13254000.0 False True 6924770.023697401 5193241.444173825 9782379.788522985 1.0 0.749951467904627 1.4126649340045225 22.723334728402154 -6.80446408207528 1.4374596987797235 0.8628092371071545 1.4228716652651379 0.8449452735197054 0.10759887864670753 0.21443984084974974 0.8742281439791184 0.05887283440174712 0.136571314711086 1.5686856290142313e-07 6.80446408207528 0.5600624281579833 AIGSASEGAQSSLQEVYHK(ub)SMTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIGSASEGAQSSLQEVYHKSMTLK 24 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 104376000.0 26843000.0 3042700.0 74490300.0 True False 25990883.658115365 4257665.977470886 54979055.76890099 1.0 0.16381382154898289 2.115320759851672 24.63150234871457 -6.790272765456579 1.495283242888329 0.5328241840010627 2.1362221803533084 0.8022001469426622 0.3555357781066774 0.23494200851395525 1.0377497233191038 0.18715283370361532 0.4380760906536249 1.6207918139146165e-07 6.790272765456579 1.6033979963522458 AIGSASEGAQSSLQEVYHK(ub)SMTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIGSASEGAQSSLQEVYHKSMTLK 24 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 276589600.0 8224600.0 95454000.0 172911000.0 True False 12477319.49880078 78419487.91449402 138735065.06041643 1.0 6.284962721522926 11.118979927840313 23.572804697678787 -7.617011516233905 0.31959944089419906 2.031589394093555e-19 14.352610654998609 0.9993016991703311 0.10920086790426786 0.14010627826008082 0.045858222683956854 0.414841772960067 1.0787386136793353 2.4153967842570905e-08 7.617011516233905 14.352610654998609 AIGSASEGAQSSLQEVYHK(ub)SMTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIGSASEGAQSSLQEVYHKSMTLK 24 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 102022700.0 26843000.0 38253000.0 36926700.0 True False 22321143.846528754 38046923.49637401 44647902.240230076 1.0 1.7045239149915175 2.000251534921829 24.411907624148846 -10.434716522526953 0.18809957129388144 2.9867422906681207e-16 2.2809441928771106 0.9994617754232376 0.009733763145433042 2.151805692166007 0.09549626101861848 1.210423846717321 0.19725318480893328 3.6752211530147104e-11 10.434716522526953 2.28094419287711 AIGSASEGAQSSLQEVYHK(ub)SMTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIGSASEGAQSSLQEVYHKSMTLK 24 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 211155600.0 8224600.0 97131000.0 105800000.0 True False 10646906.831103602 91725574.4649889 86545485.59967366 1.0 8.61523219091428 8.12869756189111 23.343931019771237 -10.184620817481385 10.563474124870043 0.9999999863256387 8.371964876402696 0.9967438393608713 0.19862693055017905 8.216406657650892e-08 6.511010674516104e-09 0.19231971142829166 0.06410656617742845 6.537010499570762e-11 10.184620817481385 7.371964890077058 AIGSASEGAQSSLQEVYHKSMTLK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIGSASEGAQSSLQEVYHKSMTLK 24 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 11586000.0 3728800.0 3701900.0 4155300.0 True False 5107438.127031083 3538337.8174537392 3173903.721089806 1.0 0.6927813376195611 0.6214277377716905 22.284168391167434 -13.999999999999833 0.20510549436891096 2.7419863228061594 0.5773508366294025 0.999487854489113 0.0037169929364651304 12.636532155123156 0.143577277707515 8.850537031902812 0.04376370194411389 1.0000000000003845e-14 13.999999999999833 -2.164635486176757 AIGSASEGAQSSLQEVYHKSMTLK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIGSASEGAQSSLQEVYHKSMTLK 24 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 29266900.0 10251800.0 7825600.0 11189500.0 True False 8524825.931745457 7783441.939540012 13529172.715597495 1.0 0.9130323600573922 1.587032136951493 23.023238945399815 -6.874476736195812 1.1102126345818017 0.9492015567299926 1.630001403185435 0.9689471021026465 0.052749385230573556 0.1326314501561491 0.3028516477992219 0.03676586380044971 0.08778303017935175 1.335129106359167e-07 6.874476736195812 0.6807998464554424 AIGSASEGAQSSLQEVYHKSMTLK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIGSASEGAQSSLQEVYHKSMTLK 24 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 58564500.0 13229100.0 20975900.0 24359500.0 True False 17125330.73454668 19808572.725701995 19926320.949577063 1.0 1.1566826377106079 1.163558313614346 24.029628514736252 -12.697696263445991 0.46299491315764046 0.0013563723412583582 1.1634593123335883 0.9998878431286679 0.0007999122315135231 11.169289317728452 0.23254751894239115 10.994652976855424 0.0015085954587688833 2.0058744038706346e-13 12.697696263445991 1.16210293999233 AIGVGLGFELQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIGVGLGFELQR 12 0 Q9NRN7;E9PLW6;E9PNF3 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 46538000.0 15010000.0 14158000.0 17370000.0 False True 22771267.377987903 11631394.283041097 13936811.886458548 1.0 0.5107925742545499 0.6120349673611369 24.440711253843933 -10.01818836538503 5.832483819127189 1.0000008234827746 0.5614137708078017 0.9615711389572057 0.041332033908537895 4.425740427907566e-07 7.44341091110879e-08 0.040019644881679 0.013339856582676326 9.589846034718116e-11 10.01818836538503 -0.4385870526749729 AIGVGLGFELQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIGVGLGFELQR 12 0 Q9NRN7;E9PLW6;E9PNF3 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 43935000.0 15010000.0 14276000.0 14649000.0 False True 19430740.891333893 13481528.050387418 11983032.311433086 1.0 0.6938247041521807 0.6167048584738998 24.211837575936382 -13.999999999999998 0.19361885353377267 2.6623263523048224 0.563348598997147 0.9994878220429563 0.003746195562688446 12.41191363356957 0.13954022982640177 7.794067344815372 0.051549299788399464 1.0000000000000041e-14 13.999999999999998 -2.0989777533076754 AIGVK(ub)PPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIGVKPPR 8 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 14842900.0 5189300.0 6759200.0 2894400.0 True False 6803222.55325269 5750753.707155238 2594915.253045297 1.0 0.8452984834967282 0.3814244253709798 22.697786853968676 -6.951461835997129 0.5425579667083796 1.0067168614659474 0.19849022688768875 0.9993110641367532 0.006898822856538847 0.08290400806019693 0.03357374892739918 0.007561544678743933 0.03843137597922969 1.1182480872836431e-07 6.951461835997129 -0.8082266345782587 down AIGVK(ub)PPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIGVKPPR 8 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 21247900.0 7558300.0 8859100.0 4830500.0 True False 7318365.903704253 12396584.829596171 3565247.1381062563 1.0 1.693900659342755 0.487164373169928 22.803090118680142 -6.750757566676077 1.6469301029337846 1.407645657863539 0.4846096302019031 0.6522749753432662 0.2915937577355372 0.298722659939307 1.5943753976224306 0.13984755633786702 0.3392572383685267 1.7751801513813812e-07 6.750757566676077 -0.9230360276616358 AIGVK(ub)PPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIGVKPPR 8 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 17953000.0 8444500.0 4934200.0 4574300.0 True False 12810923.875644188 4053653.4589194343 3670187.6000130833 1.0 0.31642163346440144 0.2864889086563658 23.610871185382766 -13.436807528405408 0.4517816552191982 9.999548671505542 0.2865950887925597 0.9998922707016925 0.003420212481355208 21.112107301431582 0.2285670042169371 186.22102832715348 0.00673256175252509 3.657568526347787e-14 13.436807528405408 -9.712953582712982 AIGVK(ub)PPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIGVKPPR 8 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 13123000.0 5189300.0 4868400.0 3065300.0 True False 7107924.445559535 4653297.990354091 2341339.2718351446 1.0 0.6546634008273823 0.32939844672910484 22.760996915491567 -7.395257857893033 0.26325824064626796 1.112015626481015 4.624119178645718e-13 0.9998865436130892 0.002916536311502609 0.11715011920175472 0.021521352649878835 0.01965755714288481 0.056328270311570894 4.0247799618820304e-08 7.395257857893033 -1.1120156264805525 down AIGVK(ub)PPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIGVKPPR 8 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 23451500.0 7558300.0 12975000.0 2918200.0 True False 6285061.33946348 12905101.099664142 3528382.1277676933 1.0 2.05329755791465 0.5613918364826797 22.58349539411442 -6.717027929108227 1.7699712266342604 1.6428581830455626 0.5641033863335176 0.4983932102841583 0.4434042397214096 0.36116569065766474 2.2095807093834763 0.19903608872083842 0.5014174039571673 1.9185453566851795e-07 6.717027929108227 -1.078754796712045 AIGVK(ub)PPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIGVKPPR 8 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 14260800.0 8444500.0 4751400.0 1064900.0 True False 10931571.71598064 4486980.41318372 871099.1267967164 1.0 0.4104606848642172 0.07968653999893487 23.381997507475216 -8.53663721133592 0.38074170948770997 1.1140891633326517 5.8051642542368085e-15 0.9973128854968285 0.019731106945019873 0.20263251606424126 0.11660519480331578 0.10650109978527053 0.08143468129369583 2.906449548442411e-09 8.53663721133592 -1.114089163332646 AIGVLTSGGDAQGMNAAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIGVLTSGGDAQGMNAAVR 19 0 P17858;Q01813 P17858;Q01813 PFKL;PFKP ATP-dependent 6-phosphofructokinase, liver type;ATP-dependent 6-phosphofructokinase, platelet type 0 9033900.0 1966200.0 3558100.0 3509600.0 False True 2577707.2407078873 3027245.349365174 3146460.2584603946 1.0 1.1743945555794904 1.2206429841102968 21.297656990369514 -13.999999999999847 0.18630971508128616 0.07674714143456973 1.2550827987681934 0.9994918646410665 0.0021416098323131065 12.293185553382708 0.1368744725771114 4.115467420684334 0.03276520591650204 1.0000000000003518e-14 13.999999999999847 1.1783356573336237 AIGVLTSGGDAQGMNAAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIGVLTSGGDAQGMNAAVR 19 0 P17858;Q01813 P17858;Q01813 PFKL;PFKP ATP-dependent 6-phosphofructokinase, liver type;ATP-dependent 6-phosphofructokinase, platelet type 0 12613300.0 1966200.0 3247400.0 7399700.0 False True 2693157.2745571006 3103919.1302842526 5652043.261605233 1.0 1.1525205600162 2.0986681004490286 21.360867051892406 -6.935133624962442 0.7033803928671203 0.9879795083706008 2.3210020999935725 0.9974544704003925 0.024518921059132403 0.09005840240866517 0.06525531111670599 0.023064541730772253 0.08332646076342058 1.161091310995487e-07 6.935133624962442 1.3330225916229717 up AIHSWLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIHSWLTR 8 0 P28070 P28070 PSMB4 Proteasome subunit beta type-4 0 23137600.0 5473900.0 5490700.0 12173000.0 False True 7176335.909323013 4671508.962580968 10913454.731661273 1.0 0.6509601865921657 1.520755838293919 22.774815990709055 -6.797776543131555 1.4648430221717794 0.8068745113591725 1.532133752636913 0.8256301825203252 0.14923827014110824 0.2239391992968356 0.9488607726720151 0.08015563814614772 0.18668142278861022 1.5930281745427256e-07 6.797776543131555 0.7252592412777404 AIHSWLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIHSWLTR 8 0 P28070 P28070 PSMB4 Proteasome subunit beta type-4 0 15572500.0 5613200.0 1560100.0 8399200.0 False True 5435012.038510342 2183056.065814021 6199197.549401099 1.0 0.4016653597721129 1.1406041983855861 22.373851800138844 -6.691299739189244 1.861955099096306 0.6253381107804392 1.1380805441062303 0.37646730067836 0.25298711141473645 0.41386848960810163 2.782927945889146 0.1086589469552923 0.28247633661513066 2.0356366472645273e-07 6.691299739189244 0.5127424333257911 AIHSWLTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIHSWLTR 8 0 P28070 P28070 PSMB4 Proteasome subunit beta type-4 0 17800800.0 4060900.0 10702000.0 3037900.0 False True 6160682.191557035 8792144.484892344 2437457.73344113 1.0 1.4271381336537083 0.39564737437382613 22.554658683212338 -6.79425719641315 1.4794378890474216 1.2374081765049483 0.383376188974155 0.8147962925367481 0.18211285479405437 0.22905168276901863 0.9902703350327722 0.0968725113764106 0.22610396725416096 1.6059898774224346e-07 6.79425719641315 -0.8540319875307933 down AIHSWLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIHSWLTR 8 0 P28070 P28070 PSMB4 Proteasome subunit beta type-4 0 20057800.0 5473900.0 6885400.0 7698500.0 False True 7497748.75658535 6581180.26102704 5880272.855584411 1.0 0.8777541732438983 0.7842717923056179 22.838026052231946 -6.974105699676227 0.1260726426232645 1.1534858807408446 0.5061276308416144 0.9999993129743288 7.29871232521099e-05 0.07499155356461532 0.0037725647141683633 0.006143935239753506 0.013033640308966024 1.0614371905232723e-07 6.974105699676227 -0.6473582498992302 AIHSWLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIHSWLTR 8 0 P28070 P28070 PSMB4 Proteasome subunit beta type-4 0 10746500.0 5613200.0 3511300.0 1622000.0 False True 4667624.50692304 3492383.9299615175 1961152.7007193451 1.0 0.7482144128735289 0.42016076867591967 22.15425707557312 -6.967492250229642 0.31233362217947813 1.0491666585966453 0.10874529442276773 0.9999556884566007 0.001580287842606335 0.07712511032661785 0.011928541885375532 0.005136660046568481 0.029059805868074086 1.0777244849834498e-07 6.967492250229642 -0.9404213641738776 down AIHSWLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIHSWLTR 8 0 P28070 P28070 PSMB4 Proteasome subunit beta type-4 0 13752600.0 4060900.0 4442500.0 5249200.0 False True 5256915.102306317 4195270.969728644 4293899.461340331 1.0 0.7980480734581565 0.816809740651225 22.325785005304787 -10.726345738589306 6.788133130183847 1.002672942012217 0.8074289070546911 0.9929312704867764 0.007659418557822153 0.00031359572472976053 1.264216509677249e-05 0.007506094436798372 0.0024720667096731056 1.8778213021023223e-11 10.726345738589306 -0.19524403495752585 AIIAPHAGYTYCGSCAAHAYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIIAPHAGYTYCGSCAAHAYK 21 0 Q9Y316;Q9Y316-3;B5MCI6 Q9Y316 MEMO1 Protein MEMO1 0 17554700.0 5448000.0 4559200.0 7547500.0 False True 7142380.758507043 3878985.131622412 6766557.100732233 1.0 0.5430941394439504 0.9473811785618991 22.76797361500503 -10.27057597056834 8.122035680355717 1.000000303198632 0.7452376590029248 0.3461725933819756 0.16504949257659948 9.061096054208587e-07 8.121492712525378e-08 0.1598086745138511 0.05326949467076287 5.3632004546675485e-11 10.27057597056834 -0.25476264419570716 AIIASNIMYIVGQYPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIIASNIMYIVGQYPR 16 0 O14980 O14980 XPO1 Exportin-1 0 5013680.0 770080.0 1312300.0 2931300.0 False True 1054799.3866295037 1254318.2468042201 2238987.312018518 1.0 1.1891533714408549 2.122666490329462 20.008537206706 -6.940097497440311 0.6586649131285919 0.9895388985958657 2.375121328687462 0.9981765325790343 0.02095645813832568 0.08772235028561728 0.05440920535438491 0.020414531190596937 0.08031123557755525 1.1478958943566465e-07 6.940097497440311 1.3855824300915964 up AIIASNIMYIVGQYPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIIASNIMYIVGQYPR 16 0 O14980 O14980 XPO1 Exportin-1 0 8874500.0 3226800.0 2582200.0 3065500.0 False True 2683227.171477812 2568289.1760734287 3706481.876729447 1.0 0.9571642697173941 1.3813522448373494 21.355537772744935 -6.882032922851508 1.0684391264695423 0.9726677374895518 1.4126059282269112 0.9752868106270199 0.02997434481438664 0.1258426205009762 0.26155663061640344 0.021570513699060774 0.052441243488866744 1.3121004279764702e-07 6.882032922851508 0.4399381907373594 AIIDEFEQK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIIDEFEQKLR 11 1 Q15021 Q15021 NCAPD2 Condensin complex subunit 1 1 4120910.0 939010.0 1239400.0 1942500.0 True False 909201.6415380867 1734298.883385618 1433700.9762491244 1.0 1.9074964278020035 1.5768790010362803 19.794240763340394 -10.026313339661531 4.983258525943703 0.9999914345807017 1.7421877144230644 0.8704521714100267 0.13497399930317064 1.564405079005732e-05 3.0568383304890485e-06 0.13068984928743382 0.043562670951907266 9.412102765270303e-11 10.026313339661531 0.7421962798423627 AIIDEFEQK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIIDEFEQKLR 11 1 Q15021 Q15021 NCAPD2 Condensin complex subunit 1 1 4469710.0 939010.0 1794200.0 1736500.0 True False 780828.4201962868 1784534.2884791845 2099594.1213311614 1.0 2.2854371617654277 2.688931482288208 19.57464603877467 -10.04696128340582 0.27995538918438195 1.984142948811889e-26 2.8585112479790737 0.9989722683505132 0.02308700244285724 1.4859872935277687 0.12697335440929705 1.3233684761816376 0.15662361491136806 8.975088022758456e-11 10.04696128340582 2.8585112479790737 AIIIFVPVPQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIIIFVPVPQLK 12 0 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 0 1367790000.0 491610000.0 527560000.0 348620000.0 False True 644505470.7580115 448850104.4127741 312548146.5991744 1.0 0.6964255926095949 0.4849425812190273 29.263617363771093 -7.923906669087562 0.13695634213150104 1.3788685262661338 3.3292616944942084e-12 0.9999700327451775 0.0011571771149585467 0.11675004751854455 0.021230606316526603 0.08697771459970659 0.10903566268280597 1.1914980362649501e-08 7.923906669087562 -1.3788685262628044 down AIIIFVPVPQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIIIFVPVPQLK 12 0 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 0 2451170000.0 976240000.0 777220000.0 697710000.0 False True 945249795.5667588 1087567999.1487548 514958820.14866215 1.0 1.150561475124852 0.5447859629949985 29.816120391293577 -6.840928690201098 1.2782024208614802 1.080084800513943 0.5245082606526796 0.9260184093149308 0.0700445101785413 0.1677182163884268 0.5319013529597051 0.042964598920617485 0.09900097398398325 1.44235216180732e-07 6.840928690201098 -0.5555765398612633 AIIIFVPVPQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIIIFVPVPQLK 12 0 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 0 2073550000.0 663580000.0 705690000.0 704280000.0 False True 1006699374.1962175 579754105.9188645 565078749.3031107 1.0 0.5758959633622098 0.5613182681813907 29.906985776548034 AIIIFVPVPQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIIIFVPVPQLK 12 0 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 0 2101390000.0 491610000.0 501480000.0 1108300000.0 False True 673371502.2607129 479322955.4274026 846542366.1549913 1.0 0.711825424476934 1.2571698732614778 29.326827425293985 -6.763122256592395 1.6005598285021674 0.8332626815338459 1.2594863416221973 0.7036288230838595 0.12126824435262888 0.27771027073943955 1.4028038625978887 0.05975867531693575 0.1431793749827622 1.7253521262872776e-07 6.763122256592395 0.42622366008835144 AIIIFVPVPQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIIIFVPVPQLK 12 0 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 0 1868050000.0 976240000.0 357690000.0 534120000.0 False True 811786814.7649367 355763052.97409403 645802022.5081486 1.0 0.4382468974654507 0.7955315493700755 29.596525666727853 -10.121578021406256 5.307306220177492 1.000008341995237 0.6168892234175333 0.605220343129989 0.14586084834989926 1.4397735273929832e-05 2.383019467260452e-06 0.14123223336268825 0.04707638637677973 7.55826263252422e-11 10.121578021406256 -0.38311911857770375 AIIIFVPVPQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIIIFVPVPQLK 12 0 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 0 1487160000.0 663580000.0 486590000.0 336990000.0 False True 859017391.1173453 459510838.7530136 275661277.8093956 1.0 0.5349261184983884 0.3209030232214928 29.678112098640483 -11.609963926348914 0.1354914525431189 2.20891008508542 3.716838276195773e-14 0.9997007707693879 0.004903784425991369 4.518939833361111 0.08846457268478763 1.838618335574115 0.23607399066416446 2.4549128187838368e-12 11.609963926348914 -2.2089100850853827 AIIIFVPVPQLKSFQK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIIIFVPVPQLKSFQK 16 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 1 26346400.0 5312100.0 4385300.0 16649000.0 True False 8058844.066529617 3602708.952494715 13358317.852484057 1.0 0.44705033659326665 1.6575972611214147 22.942141487595862 -6.78250038687606 1.5260234440270741 0.6879250080916867 1.6679679921955362 0.7761773813036358 0.23409828455875936 0.24670563135265405 1.1348985576269355 0.12080267137265563 0.2844662863335717 1.650059531421712e-07 6.78250038687606 0.9800429841038495 AIIK(ub)PQYVDQIPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIIKPQYVDQIPK 13 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 39410800.0 5270000.0 6520800.0 27620000.0 True False 7994975.288607348 5357112.292757064 22160894.893723927 1.0 0.6700598937923953 2.771852831778315 22.93066214386046 -6.8667628359297685 1.1509902887716053 0.8165719833935944 2.887649662513782 0.9613491690563105 0.18144228429288217 0.14000157083361345 0.3486609652201665 0.12256009923609307 0.28866275529818847 1.3590554111635684e-07 6.8667628359297685 2.071077679120188 up AIIK(ub)PQYVDQIPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIIKPQYVDQIPK 13 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 27231000.0 5270000.0 5849000.0 16112000.0 True False 6822118.8872304885 5523498.008315776 13179781.323080737 1.0 0.8096455221052441 1.9319190329195814 22.70178846595291 -6.863238985190622 1.1691856173056134 0.895683063426319 1.9897448808825007 0.9574615814029944 0.101139007526837 0.14350668917775486 0.37093237403794044 0.06737171478398171 0.15789268053365949 1.3701275997448603e-07 6.863238985190622 1.0940618174561818 AIIKPQYVDQIPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIIKPQYVDQIPK 13 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 4664580.0 1480000.0 657580.0 2527000.0 False True 1433018.2101110423 920155.1232343984 1865102.8916249857 1.0 0.6421098606716917 1.3015207193218166 20.450625512120304 -6.759290879849916 1.6152491194857428 0.7919500759783636 1.303842909740561 0.6881630182313964 0.15051250263069463 0.28403804182746795 1.4604229557179609 0.07353018275272749 0.17682083635098572 1.7406406442365037e-07 6.759290879849916 0.5118928337621974 AIILFNPDAK(ub)GLSNPSEVEVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIILFNPDAKGLSNPSEVEVLR 22 1 A0A0G2JKR7;P28702;P28702-3 A0A0G2JKR7 RXRB Retinoic acid receptor RXR-beta 1 17446500.0 8251800.0 6247300.0 2947400.0 True False 7989851.125806964 8741879.469239123 2175387.519895324 1.0 1.0941229481739818 0.27226884276590485 22.929737191118104 -6.878403099626987 1.0886296630678396 1.0571952919427137 0.21577072933459546 0.9723759899325072 0.06103976235686053 0.12905577621346084 0.2808931870800633 0.043251312904617915 0.10418455817640704 1.3231128898180347e-07 6.878403099626987 -0.8414245626081183 down AIILFNPDAK(ub)GLSNPSEVEVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIILFNPDAKGLSNPSEVEVLR 22 1 A0A0G2JKR7;P28702;P28702-3 A0A0G2JKR7 RXRB Retinoic acid receptor RXR-beta 1 14944200.0 8251800.0 4022100.0 2670300.0 True False 6861737.3167226445 4000432.148975656 3228647.3839277914 1.0 0.5830057264399 0.47052914369940974 22.71014246655238 -13.999999999999998 0.18389813844560288 3.1902557699372327 0.38468890242997117 0.9994939513774985 0.00512359406279547 12.257653533609831 0.13597162420585301 9.602354568449393 0.08127742671238658 1.0000000000000041e-14 13.999999999999998 -2.8055668675072614 AIIVEFAQQGLNAALFYENKDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIIVEFAQQGLNAALFYENKDPR 23 1 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 54215400.0 9901400.0 15827000.0 28487000.0 False True 15021147.689301098 13002548.193084588 22856531.963704348 1.0 0.8656161607641826 1.521623542785885 23.840491710246628 -6.853325999161383 1.2189109581340463 0.9280283471929869 1.5495831408502967 0.945008678800869 0.06635009577269273 0.15383714583537667 0.43815871768003417 0.0425548107813047 0.0987083578603962 1.401761090464403e-07 6.853325999161383 0.6215547936573098 AIK(ub)AWNNPSPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIKAWNNPSPR 11 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 6674500.0 1396300.0 2420700.0 2857500.0 True False 1830562.821788433 2059540.9958146974 2561833.3110754983 1.0 1.1250862146334624 1.3994784994992004 20.8038558546451 -6.958198086980602 0.460126414257861 0.9920120437519967 1.5436162838933432 0.9996974171658676 0.002902163584701094 0.08035119384583635 0.023558008142625934 0.0037273581956708893 0.022667243437247766 1.1010369986658984e-07 6.958198086980602 0.5516042401413465 AIK(ub)AWNNPSPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIKAWNNPSPR 11 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 13238800.0 1206400.0 2302600.0 9729800.0 True False 1168103.4923499748 3222040.187900368 7181273.492256747 1.0 2.758351643498909 6.147805857347072 20.155736669985295 -6.960759270981049 0.42459837341629325 0.8573927750724727 8.177592721736128 0.9997973290179861 0.030415173526823415 0.0794310115566503 0.02013741848010938 0.043989393763229676 0.2818007436170151 1.0945629133358951e-07 6.960759270981049 7.320199946663655 AIK(ub)AWNNPSPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIKAWNNPSPR 11 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 39031800.0 3489500.0 9265300.0 26277000.0 True False 5293826.616621516 7611834.824880693 21083339.432381738 1.0 1.437870065668776 3.9826274941050075 22.335879513791685 -6.936514814140835 0.6912375626594038 0.9689952868347502 4.603767531573637 0.9976706696193339 0.0634671713098203 0.08939347516200756 0.06212619572706326 0.060256104465294544 0.22259275558302033 1.1574045514007335e-07 6.936514814140835 3.634772244738887 up AIK(ub)AWNNPSPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIKAWNNPSPR 11 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 7076900.0 1396300.0 1851600.0 3829000.0 True False 1912549.8435886852 1769790.189577608 2924669.060730362 1.0 0.9253563746379521 1.5291988705729878 20.86706591616799 -6.875950125268902 1.1021832624641745 0.9558117869329418 1.568795996711661 0.9702671177306547 0.04634864610821706 0.13127566008463076 0.29450591436473583 0.03250371286657048 0.07785163772208535 1.3306072172178628e-07 6.875950125268902 0.6129842097787191 AIK(ub)AWNNPSPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIKAWNNPSPR 11 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 11479300.0 1206400.0 4830500.0 5442400.0 True False 1003175.0525817638 4804477.137720827 6580380.677185559 1.0 4.789270950624281 6.559553749119199 19.93614194541957 -8.789445361369875 0.3466808542932477 7.136694605257313e-23 7.140131502801732 0.9980151430947395 0.10331681797115136 0.3288858485928794 0.1144602218019954 0.9672264487488448 0.5086688233432242 1.623882638460809e-09 8.789445361369875 7.140131502801732 AIK(ub)AWNNPSPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIKAWNNPSPR 11 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 30764300.0 3489500.0 5272800.0 22002000.0 True False 4517226.538328432 4979364.044836287 17997861.759584304 1.0 1.1023055856478845 3.984272563457552 22.107005835884134 -6.9144256977255525 0.8650620262458664 0.922767360180351 4.39423897326359 0.9924870853613816 0.11990182923313338 0.10156343551739584 0.12343387555971888 0.10036616987030761 0.2863319652300268 1.2177953243488966e-07 6.9144256977255525 3.4714716130832395 up AIK(ub)QVYEEEYGSSLEDDVVGDTSGYYQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIKQVYEEEYGSSLEDDVVGDTSGYYQR 28 1 P08758;D6RBL5;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 1 16679800.0 6477700.0 3635200.0 6566900.0 True False 6272068.959213706 5086754.3173175715 4846831.887222842 1.0 0.8110169627272832 0.7727644448332823 22.580509990793992 -13.999999999999998 0.2245619218098993 2.163749187911337 0.753176544712538 0.9995028661863528 0.002214900641037727 13.127788194748247 0.1500860141744598 6.791387974566489 0.020550732422729163 1.0000000000000041e-14 13.999999999999998 -1.4105726431987988 AIK(ub)QVYEEEYGSSLEDDVVGDTSGYYQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIKQVYEEEYGSSLEDDVVGDTSGYYQR 28 1 P08758;D6RBL5;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 1 45988400.0 8898400.0 16945000.0 20145000.0 True False 13499523.360179074 13921032.358110726 16163331.920132836 1.0 1.0312239911503114 1.1973261195140763 23.686405133854645 -6.938432147114569 0.673987400295716 0.9980753616679079 1.2401260996946715 0.9979513096538617 0.003919911033553674 0.08848910399250992 0.057920866637428736 0.003771864649596326 0.014397617486361373 1.1523060786564315e-07 6.938432147114569 0.24205073802676358 AIK(ub)QVYEEEYGSSLEDDVVGDTSGYYQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIKQVYEEEYGSSLEDDVVGDTSGYYQR 28 1 P08758;D6RBL5;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 1 15708300.0 6477700.0 5303600.0 3927000.0 True False 5386494.560766642 5275028.454117824 4748117.5436035 1.0 0.9793063734881127 0.881485628554634 22.360915266228268 -6.94106797396247 0.6495844363021993 1.0010810077911882 0.8542594880098683 0.9983000526056418 0.002131018605434634 0.08728354289373103 0.052422790884763155 0.0020915222065776974 0.008380453253084442 1.1453336645638432e-07 6.94106797396247 -0.14682151978131996 AIK(ub)QVYEEEYGSSLEDDVVGDTSGYYQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIKQVYEEEYGSSLEDDVVGDTSGYYQR 28 1 P08758;D6RBL5;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 1 42166400.0 8898400.0 12067000.0 21201000.0 True False 11519154.213687262 11395460.842254488 17342635.54063027 1.0 0.9892619397971251 1.5055476486306125 23.457531455947095 -6.9021538345365325 0.9475762451346562 0.9797842962625122 1.5621696729896193 0.987606819641187 0.02681681068444227 0.1098369683182582 0.16862472200222248 0.02113684310263593 0.055611636182821625 1.2526973695016255e-07 6.9021538345365325 0.5823853767271071 AILCLLLGGVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AILCLLLGGVER 12 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 39859000.0 14247000.0 16595000.0 9017000.0 False True 18677954.968144245 14119090.68680337 8084007.337171573 1.0 0.75592272874005 0.43281008820071926 24.154833168572452 -6.967250483836709 0.3170634914780387 1.0458030461453431 0.13255281834620097 0.9999523011039924 0.0016043723080827145 0.07720537751284952 0.012209426550522673 0.004957388639502651 0.028496656179852472 1.07832460796503e-07 6.967250483836709 -0.9132502277991421 down AILCLLLGGVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AILCLLLGGVER 12 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 83295700.0 59246000.0 16654000.0 7395700.0 False True 57365268.15962086 23304029.049462683 5458544.303755806 1.0 0.40623934650873433 0.09515416695285404 25.773674184742962 -8.68708861028841 0.34835426389897417 1.155335084384914 2.263847230899068e-23 0.9979246483328964 0.017100014244125345 0.27213069999678696 0.11090878126545099 0.1393569261870185 0.0852815727633795 2.0554711698047425e-09 8.68708861028841 -1.155335084384914 AILCLLLGGVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 AILCLLLGGVER 12 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 1203720000.0 302950000.0 476680000.0 424090000.0 False True 459597298.6116889 391612729.6821607 340268425.61474985 1.0 0.8520779623055008 0.740362109704741 28.775795077337552 -6.974228984965151 0.11988251384452206 1.2013716976919422 0.3881981848800121 0.9999994470696382 7.886239050219261e-05 0.07495273204397396 0.0035696467261683695 0.007880289323466252 0.01611330751857129 1.0611359179443111e-07 6.974228984965151 -0.8131735128119301 AILCLLLGGVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AILCLLLGGVER 12 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 178914000.0 14247000.0 60177000.0 104490000.0 False True 19514500.910698276 57518181.161272325 79811614.03910044 1.0 2.9474584784148696 4.089861913678047 24.218043230095343 -8.584353287694064 0.24614849390161989 1.9140013388382955e-18 4.990428104885862 0.9993258180253705 0.033121569599837634 0.2058637172976249 0.06902037391710922 0.6098036812063761 0.4563001413662913 2.60403437136369e-09 8.584353287694064 4.990428104885862 AILCLLLGGVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AILCLLLGGVER 12 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 119018600.0 59246000.0 3778600.0 55994000.0 False True 49265674.04282094 3758243.931806628 67702086.51299575 1.0 0.07628524332256212 1.3742243017755156 25.55407946017724 -6.715580721911949 1.7751846521326955 0.4353956399867216 1.371723551917751 0.4916332644906488 0.3889265702267882 0.3639586979072681 2.2389825242535597 0.17412693183828262 0.4394175878304122 1.9249492233006022e-07 6.715580721911949 0.9363279119310295 AILCLLLGGVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AILCLLLGGVER 12 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 854760000.0 302950000.0 279810000.0 272000000.0 False True 392174747.0372828 264238327.527242 222498790.9556828 1.0 0.6737770076310439 0.5673460431518569 28.54692139943 -13.999999999999998 0.15661556236873353 2.5956490917117114 0.45871132279045235 0.9995456817435362 0.003923416868429009 11.988819130151699 0.12493869416569454 5.813299447263246 0.09860729063233996 1.0000000000000041e-14 13.999999999999998 -2.136937768921259 AILIFNNHGKPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AILIFNNHGKPR 12 1 F5H459;Q92572 F5H459 AP3S1 AP-3 complex subunit sigma-1 0 30745300.0 7391900.0 8547400.0 14806000.0 False True 9690852.483261438 7272161.237504254 13274017.149180692 1.0 0.7504150176741543 1.3697471065737807 23.208192151298636 -6.797303908833608 1.4667756218885053 0.8618206850685117 1.3777509962264154 0.8242117885842928 0.10667203798536079 0.22461900392192635 0.9542959078968983 0.05721948752311903 0.13330299198081652 1.594762780039572e-07 6.797303908833608 0.5159303111579037 AILIFNNHGKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AILIFNNHGKPR 12 1 F5H459;Q92572 F5H459 AP3S1 AP-3 complex subunit sigma-1 0 20023200.0 9050600.0 2148000.0 8824600.0 False True 8763293.657047968 3005707.6016720245 6513172.527674654 1.0 0.34298834653962024 0.7432333986019478 23.063041773581404 -10.770313078421099 6.800208728420415 1.012528290480485 0.543110872571052 0.6346944547117747 0.16339935827106508 0.03070537279315475 0.001037116873178168 0.1565251426187554 0.052736916113734496 1.6970198472627752e-11 10.770313078421099 -0.46941741790943314 AILIFNNHGKPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AILIFNNHGKPR 12 1 F5H459;Q92572 F5H459 AP3S1 AP-3 complex subunit sigma-1 0 8073800.0 3384900.0 2579700.0 2109200.0 False True 5135140.769337197 2119332.3797119027 1692315.6955048 1.0 0.41271164217479656 0.32955585280347255 22.29197239493114 -13.999999999999982 0.27536579812953954 5.666368288527244 0.3033576627253033 0.9995949742274762 0.006005128210320387 15.153221901291726 0.16617058353628897 39.71165345056032 0.03363494914293094 1.0000000000000409e-14 13.999999999999982 -5.363010625801941 AILIFNNHGKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AILIFNNHGKPR 12 1 F5H459;Q92572 F5H459 AP3S1 AP-3 complex subunit sigma-1 0 19108800.0 7391900.0 5707200.0 6009700.0 False True 10124885.188586429 5455037.032813416 4590332.633656631 1.0 0.5387751990474682 0.4533713269984747 23.271402212821528 -13.999999999999998 0.237172887543099 4.011582668630199 0.414583169200793 0.9995203841697444 0.0052581830895569275 13.525282332794275 0.15415271019667126 19.26005245575439 0.042436172845511176 1.0000000000000041e-14 13.999999999999998 -3.596999499429406 AILIFNNHGKPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AILIFNNHGKPR 12 1 F5H459;Q92572 F5H459 AP3S1 AP-3 complex subunit sigma-1 0 16215300.0 9050600.0 3519300.0 3645400.0 False True 7525974.909562749 3500340.832373643 4407636.285574789 1.0 0.46510131570143765 0.5856565213862596 22.84344704901568 -9.87005471746004 6.669776002775284 1.0000000137995557 0.5253789185439459 0.9538451815392358 0.04921645662741315 1.0072205898837898e-08 1.8098967072460719e-09 0.04765363063948543 0.015884543073099593 1.3487929352953867e-10 9.87005471746004 -0.4746210952556098 AILIFNNHGKPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AILIFNNHGKPR 12 1 F5H459;Q92572 F5H459 AP3S1 AP-3 complex subunit sigma-1 0 14615800.0 3384900.0 6175600.0 5055300.0 False True 4381819.776354174 5831922.431211305 4135287.27175832 1.0 1.330936170100466 0.94373741569057 22.06309871702359 -6.6803858232516555 1.900245224053318 1.2093176811949127 0.9451995069947146 0.32589638186844394 0.14024755804494496 0.4377344373615745 3.0562514110386636 0.059210595189983804 0.15610237077260045 2.087440843483475e-07 6.6803858232516555 -0.2641181742001981 AILQATLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AILQATLR 8 0 Q12904;Q12904-2;A0A5F9ZHC5;D6R937 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 0 58763000.0 20469000.0 22121000.0 16173000.0 False True 26835057.22207797 18820633.026982654 14499573.102370625 1.0 0.7013449932761232 0.5403220489666559 24.677615628675042 -13.999999999999964 0.07592395296766145 2.6533357882227584 0.020990084802996203 0.9999029481075987 0.0018761680829791282 12.299455955716894 0.0763223199063532 3.483631771179759 0.4741677837444958 1.0000000000000819e-14 13.999999999999964 -2.6323457034197624 AILQATLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AILQATLR 8 0 Q12904;Q12904-2;A0A5F9ZHC5;D6R937 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 0 26515600.0 12317000.0 5825600.0 8373000.0 False True 11926003.576984936 8151792.460102674 6179860.115384262 1.0 0.6835309420696621 0.5181836543559564 23.507607338796106 -13.99999999992872 0.08196371633474388 2.686905288251075 0.041869516272909205 0.9998784429926492 0.002203945626721201 12.239131595306926 0.08111800474022136 3.7107200810314898 0.4315437275143572 1.000000000164128e-14 13.99999999992872 -2.645035771978166 AILQATLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AILQATLR 8 0 Q12904;Q12904-2;A0A5F9ZHC5;D6R937 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 0 108333000.0 16514000.0 47359000.0 44460000.0 False True 25052945.33511612 38907416.432444125 35672461.51248973 1.0 1.5530076768222747 1.4238829421181265 24.57847688721595 -10.006658394161116 4.592078082085552 0.9999870168681184 1.4884453093177021 0.9501963005583633 0.05271495232175899 18177522.235414818 1.1079242303613823 2576.7574300437386 0.018045730296995046 9.847854102697097e-11 10.006658394161116 0.4884582924495837 AILQATLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AILQATLR 8 0 Q12904;Q12904-2;A0A5F9ZHC5;D6R937 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 0 75274000.0 20469000.0 16200000.0 38605000.0 False True 28036942.45392597 15484230.43376391 29487294.09493223 1.0 0.5522795668325694 1.0517300216808472 24.740825690197934 -6.670436337573012 1.9358098428657764 0.7143196690883303 1.0497122333311244 0.28087064531062744 0.1901647842497253 0.46018988973433594 3.3250839733363406 0.0790723841995639 0.21114271614160435 2.135815148304063e-07 6.670436337573012 0.33539256424279407 AILQATLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AILQATLR 8 0 Q12904;Q12904-2;A0A5F9ZHC5;D6R937 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 0 29354500.0 12317000.0 7754300.0 9283200.0 False True 10242131.235618018 7712526.04679196 11224274.199332831 1.0 0.7530196469237664 1.0958924408524775 23.288012614230382 -6.713458318127988 1.7833273156276588 0.8486974388975523 1.095155988657524 0.48132290362983465 0.10402187178999271 0.3681575164691088 2.2845058498943542 0.046386658295276606 0.11733253307157407 1.9343795038281833e-07 6.713458318127988 0.2464585497599716 AILQATLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AILQATLR 8 0 Q12904;Q12904-2;A0A5F9ZHC5;D6R937 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 0 94318000.0 16514000.0 46945000.0 30859000.0 False True 21377698.53960616 44332469.48202846 25242978.640078753 1.0 2.0737718515346413 1.1808089908888668 24.3496032093084 -10.261058179227744 4.201159640871404 0.9995074085419817 1.627290421236442 0.3968545207086812 0.36455056138776953 51738977.98347208 63185830.25394515 193836.96758268005 0.12479536119258478 5.4820352122022796e-11 10.261058179227744 0.6277830126944604 AILQNHTDFKDK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 AILQNHTDFKDK 12 1 Q86X55-1;Q86X55;Q86X55-2;K7EQA8 Q86X55-1 CARM1 Histone-arginine methyltransferase CARM1 1 5160600.0 1000700.0 2341800.0 1818100.0 True False 1311927.390792584 1992412.5682649035 1629980.452446671 1.0 1.5186911884362846 1.2424319088741178 20.323256444888244 -10.174489524471657 4.647825769041696 0.999944589177357 1.3805615486587528 0.7167299048761782 0.11278237861818825 6.476667524032304e-05 1.1503213384418504e-05 0.10921692931893359 0.03640035617610766 6.69129959798066e-11 10.174489524471657 0.38061695948139584 AILQNHTDFKDK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 AILQNHTDFKDK 12 1 Q86X55-1;Q86X55;Q86X55-2;K7EQA8 Q86X55-1 CARM1 Histone-arginine methyltransferase CARM1 1 11017800.0 2697300.0 3133200.0 5187300.0 True False 4092001.2990437634 2574055.9801966674 4162027.8813256463 1.0 0.6290457387680165 1.0171130400907367 21.96437517240441 -10.990696004262583 12.100589713012088 1.1365194702531076 0.8230793894293761 0.21699355340593585 0.1584278123499253 0.0675276288738497 5.192115856432255e-05 0.017752705818942508 0.05113235656727787 1.0216543670695823e-11 10.990696004262583 -0.31344008082373154 AILQNHTDFKDK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AILQNHTDFKDK 12 1 Q86X55-1;Q86X55;Q86X55-2;K7EQA8 Q86X55-1 CARM1 Histone-arginine methyltransferase CARM1 1 4678700.0 1000700.0 1671500.0 2006500.0 True False 1370685.8329006643 1597647.6030886646 1532606.0251646556 1.0 1.1655826337007515 1.118130784150102 20.386466506411136 -10.097583225541875 4.470568991933713 0.9999868920906747 1.141856708898181 0.9225769242392619 0.01937213648269085 2.5311378202149805e-06 5.109158120563218e-07 0.018758723203644433 0.0062523301614199394 7.987608573478676e-11 10.097583225541875 0.14186981680750632 AILQNHTDFKDK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AILQNHTDFKDK 12 1 Q86X55-1;Q86X55;Q86X55-2;K7EQA8 Q86X55-1 CARM1 Histone-arginine methyltransferase CARM1 1 7589300.0 1374000.0 4327000.0 1888300.0 True False 1142541.8785206757 4303689.592157746 2283134.7994872625 1.0 3.766767479656865 1.998294191582183 20.12381561585637 -10.20689869075415 6.155902995627638 0.9999753119901714 2.8825308356195296 0.601731023496602 0.7219761965875157 0.0002446294621100532 3.1515279441049834e-05 0.6990595261994409 0.2330168154784656 6.210138832052081e-11 10.20689869075415 1.882555523629358 AILQNHTDFKDK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AILQNHTDFKDK 12 1 Q86X55-1;Q86X55;Q86X55-2;K7EQA8 Q86X55-1 CARM1 Histone-arginine methyltransferase CARM1 1 11063300.0 2697300.0 5126100.0 3239900.0 True False 3491708.021731846 4840828.028795949 2650271.4441813105 1.0 1.3863782420143353 0.7590186314796181 21.73550149449686 -6.7400914470188145 1.686457824547703 1.2298708687894342 0.7586506735862808 0.6053084411810898 0.1623391657362289 0.3176526391710381 1.7739815112807713 0.07615200302472118 0.18684447088317588 1.8193177344691244e-07 6.7400914470188145 -0.4712201952031534 AILSTKPPGTFLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AILSTKPPGTFLLR 14 1 G8JLH9;P40763-3;P40763-2;P40763 G8JLH9 STAT3 Signal transducer and activator of transcription;Signal transducer and activator of transcription 3 0 5722000.0 2332200.0 1126700.0 2263100.0 False True 3194477.3653351986 1076918.6685013443 1728602.3900075427 1.0 0.33711889155562774 0.5411221280718511 21.607148486688843 -10.067408183035427 5.394609216785405 1.0000052227729732 0.43912050981334155 0.909736554432946 0.08328397255845371 5.231534131851055e-06 9.043599364092762e-07 0.08064011034701127 0.02687978656017427 8.562327142016354e-11 10.067408183035427 -0.5608847129596317 AILVDLEPGTMDSVR ddPTM_RPMI8226_Bortezomib_1h_R1 2 AILVDLEPGTMDSVR 15 0 A0A0B4J269;Q13509;G3V5W4;G3V2R8;G3V3R4;G3V2N6;P07437;Q5JP53;Q13885;Q9BVA1 A0A0B4J269;P07437;Q13885;Q9BVA1 TUBB3;TUBB;TUBB2A;TUBB2B Tubulin beta-3 chain;Tubulin beta chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 285267000.0 49078000.0 134559000.0 101630000.0 False True 64341733.27202802 114483321.706874 91114302.5037982 1.0 1.779301176467445 1.4160995961762397 25.939251464816394 -10.0937833062214 4.447386483955948 0.999948604870284 1.5977003861001924 0.7831206015211378 0.14827642438790875 51574837.76986692 3.447168441913517 29440.30502381648 0.050758963968587915 8.057803897642802e-11 10.0937833062214 0.5977517812299084 AILVDLEPGTMDSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AILVDLEPGTMDSVR 15 0 A0A0B4J269;Q13509;G3V5W4;G3V2R8;G3V3R4;G3V2N6;P07437;Q5JP53;Q13885;Q9BVA1 A0A0B4J269;P07437;Q13885;Q9BVA1 TUBB3;TUBB;TUBB2A;TUBB2B Tubulin beta-3 chain;Tubulin beta chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 213587000.0 91758000.0 37265000.0 84564000.0 False True 88845192.5157899 52145108.834407724 62414151.53437894 1.0 0.5869209954735627 0.7025045448946095 26.40479037719847 -10.32442465633342 8.415954195655535 1.0000007327712972 0.6447127701840885 0.9264604430243755 0.047186786456887765 6.487373448498045e-07 5.209672719700885e-08 0.04568850346983659 0.015229469842380999 4.737784946039209e-11 10.32442465633342 -0.35528796258720874 AILVDLEPGTMDSVR ddPTM_RPMI8226_Bortezomib_8h_R1 2 AILVDLEPGTMDSVR 15 0 A0A0B4J269;Q13509;G3V5W4;G3V2R8;G3V3R4;G3V2N6;P07437;Q5JP53;Q13885;Q9BVA1 A0A0B4J269;P07437;Q13885;Q9BVA1 TUBB3;TUBB;TUBB2A;TUBB2B Tubulin beta-3 chain;Tubulin beta chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 789151000.0 56807000.0 660000000.0 72344000.0 False True 86180372.14799203 542217843.3964635 58045176.69049835 1.0 6.291662821614968 0.6735312837918719 26.360855992584447 -6.659728344678491 1.9741553931531122 4.407092344081572 0.6972040733375234 0.23423953113054585 2.2532498272265054 0.48515493797468906 3.634582740979607 0.9222917562091834 2.4972796112079805 2.1891305176987542e-07 6.659728344678491 -3.7098882707440484 AILVDLEPGTMDSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AILVDLEPGTMDSVR 15 0 A0A0B4J269;Q13509;G3V5W4;G3V2R8;G3V3R4;G3V2N6;P07437;Q5JP53;Q13885;Q9BVA1 A0A0B4J269;P07437;Q13885;Q9BVA1 TUBB3;TUBB;TUBB2A;TUBB2B Tubulin beta-3 chain;Tubulin beta chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 279237000.0 49078000.0 129356000.0 100803000.0 False True 67223462.88308065 123640624.19691136 76995407.50295186 1.0 1.8392480674783902 1.1453650883303528 26.002461526339285 -10.12842031615285 4.2690426177125715 0.9999095946802351 1.4923065779381013 0.4016196021599121 0.2832765401900692 98869905.18972169 17.030623362283684 90998.08790691594 0.0969730943960685 7.440115607620239e-11 10.12842031615285 0.4923969832578662 AILVDLEPGTMDSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AILVDLEPGTMDSVR 15 0 A0A0B4J269;Q13509;G3V5W4;G3V2R8;G3V3R4;G3V2N6;P07437;Q5JP53;Q13885;Q9BVA1 A0A0B4J269;P07437;Q13885;Q9BVA1 TUBB3;TUBB;TUBB2A;TUBB2B Tubulin beta-3 chain;Tubulin beta chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 177953900.0 106935000.0 38263000.0 32755900.0 False True 88921190.52373245 38056869.624389134 39605007.24383034 1.0 0.4279842566236449 0.4453944780829271 26.4060239282668 -9.92795900122996 7.14188964290953 1.000000012426519 0.43668936738651326 0.9992840821138783 0.00710769314735313 1.404796346305106e-09 2.1538356368273314e-10 0.006881994399960487 0.002293998099137026 1.1804320669053323e-10 9.92795900122996 -0.5633106450400056 AILVDLEPGTMDSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AILVDLEPGTMDSVR 15 0 A0A0B4J269;Q13509;G3V5W4;G3V2R8;G3V3R4;G3V2N6;P07437;Q5JP53;Q13885;Q9BVA1 A0A0B4J269;P07437;Q13885;Q9BVA1 TUBB3;TUBB;TUBB2A;TUBB2B Tubulin beta-3 chain;Tubulin beta chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 144076000.0 35668000.0 69584000.0 38824000.0 False True 46172929.121392235 65711589.23074799 31758430.367880296 1.0 1.4231626730456517 0.6878149377178325 25.460543921287243 -6.750640849221872 1.647332203029137 1.2486305852210895 0.6862688759986366 0.6517806656646616 0.17782219181085912 0.29892879851008186 1.5962143233743495 0.0852628949800178 0.20686761582763002 1.7756572984811232e-07 6.750640849221872 -0.5623617092224529 AIMTYVSSFYHAFSGAQK ddPTM_RPMI8226_Bortezomib_1h_R1 2 AIMTYVSSFYHAFSGAQK 18 0 O43707;P12814-2;P12814;P12814-3;P12814-4;H9KV75;G3V2W4;G3V2N5 O43707 ACTN4;ACTN1 Alpha-actinin-4;Alpha-actinin-1 0 110769120.0 30175700.0 47664520.0 32928900.0 False True 39560634.921894476 40553159.41084378 29521733.304312885 1.0 1.0250886895751008 0.7462401289210439 25.237562244790812 -6.8849333454009205 1.051852042443009 1.0168526162180238 0.7245051591232997 0.9774537328835252 0.018912536990764405 0.12335202020368485 0.24661341592679312 0.013782674438549192 0.03379109661989948 1.303366801083981e-07 6.8849333454009205 -0.2923474570947241 AIMTYVSSFYHAFSGAQK ddPTM_RPMI8226_Bortezomib_2h_R1 2 AIMTYVSSFYHAFSGAQK 18 0 O43707;P12814-2;P12814;P12814-3;P12814-4;H9KV75;G3V2W4;G3V2N5 O43707 ACTN4;ACTN1 Alpha-actinin-4;Alpha-actinin-1 0 750422100.0 209909500.0 216750100.0 323762500.0 False True 203246037.82115126 303299545.266839 238959388.5831957 1.0 1.4922777758340904 1.1757148682695149 27.598651987062212 -10.167835011011586 4.860892677606361 0.9999698981709714 1.3339963220507673 0.597461251464862 0.12923626584146236 4.217126909868223e-05 7.219811249839372e-06 0.12514374372303877 0.041710825443604965 6.794617119014367e-11 10.167835011011586 0.334026423879796 AIMTYVSSFYHAFSGAQK ddPTM_RPMI8226_Bortezomib_8h_R1 2 AIMTYVSSFYHAFSGAQK 18 0 O43707;P12814-2;P12814;P12814-3;P12814-4;H9KV75;G3V2W4;G3V2N5 O43707 ACTN4;ACTN1 Alpha-actinin-4;Alpha-actinin-1 0 522237700.0 138021000.0 153052700.0 231164000.0 False True 209387947.68669358 125739249.87879685 185474334.07721964 1.0 0.6005085357966258 0.8857927885837259 27.641603162623362 -9.985075145501238 6.131549399753089 1.0000001536797225 0.7431506621901561 0.5194125632483779 0.11646680849666478 2.4460884089331937e-07 4.042315782852102e-08 0.112768570478291 0.037589500807782235 1.0349630726522278e-10 9.985075145501238 -0.2568494914895664 AIMTYVSSFYHAFSGAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AIMTYVSSFYHAFSGAQK 18 0 O43707;P12814-2;P12814;P12814-3;P12814-4;H9KV75;G3V2W4;G3V2N5 O43707 ACTN4;ACTN1 Alpha-actinin-4;Alpha-actinin-1 0 328659900.0 30175700.0 74187500.0 224296700.0 False True 41332471.75763026 70909650.9447444 171322438.9955393 1.0 1.7155918320237884 4.144984118059961 25.300772306313704 -6.948642400725899 0.5735538353785993 0.9702036427919064 5.009210855359248 0.9990903983722267 0.040594201812591844 0.084035501091462 0.03825402909546137 0.0428347753328739 0.20259618070682703 1.1255313581452414e-07 6.948642400725899 4.039007212567341 AIMTYVSSFYHAFSGAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AIMTYVSSFYHAFSGAQK 18 0 O43707;P12814-2;P12814;P12814-3;P12814-4;H9KV75;G3V2W4;G3V2N5 O43707 ACTN4;ACTN1 Alpha-actinin-4;Alpha-actinin-1 0 771462490.0 209909500.0 236657290.0 324895700.0 False True 174549049.81756598 235382370.20597568 392829888.7220119 1.0 1.3485170526679524 2.250541547677213 27.379057262496488 -6.9547145614924535 0.5044388343246872 0.9826097890632711 2.655648812290254 0.9995212048675768 0.011530118486032 0.08164604884883263 0.02854153047873147 0.01341159431159795 0.0744224245117601 1.1099040560940953e-07 6.9547145614924535 1.6730390232269827 up AIMTYVSSFYHAFSGAQK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AIMTYVSSFYHAFSGAQK 18 0 O43707;P12814-2;P12814;P12814-3;P12814-4;H9KV75;G3V2W4;G3V2N5 O43707 ACTN4;ACTN1 Alpha-actinin-4;Alpha-actinin-1 0 402601500.0 138021000.0 154473200.0 110107300.0 False True 178670905.30065268 145876630.62714392 90068901.19630383 1.0 0.8164543095680561 0.5041050250724555 27.41272948471581 -6.963075639276859 0.3896716107467147 1.0192536822760616 0.290088546970951 0.9998678150189935 0.002353601819946154 0.07862020722694173 0.01720134630172879 0.004033535604146957 0.02627793180106442 1.0887404553896077e-07 6.963075639276859 -0.7291651353051106 AINCATSGVVGLVNCLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AINCATSGVVGLVNCLR 17 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 21844100.0 2229200.0 7293900.0 12321000.0 False True 3053395.4818648556 6971631.380298178 9411033.558960248 1.0 2.2832389127792467 3.0821534959541097 21.541983031706593 -8.524795923884367 0.1948666892586368 6.4325832684084206e-18 4.053950710654789 0.9997184344409664 0.014391573773030778 0.17151918481296272 0.051092410383425234 0.4879900763485673 0.40153364354839516 2.986785787687865e-09 8.524795923884367 4.053950710654789 AINFNFGYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AINFNFGYAK 10 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;C9J165;A0A0U1RR66 P47897 QARS Glutamine--tRNA ligase 0 79023000.0 23266000.0 26606000.0 29151000.0 False True 30501951.3082645 22636488.509375736 26134734.15613717 1.0 0.7421324714803536 0.856821712552402 24.862398203697147 -10.16034682068915 4.7985341241778725 1.0000182754520381 0.7994770920168787 0.802989815864361 0.04682168660659237 65573349.90110641 1.8400884812038403 13586.560342882574 0.01602830870863228 6.912787062161965e-11 10.16034682068915 -0.20054118343515948 AINFNFGYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AINFNFGYAK 10 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;C9J165;A0A0U1RR66 P47897 QARS Glutamine--tRNA ligase 0 31453000.0 21795000.0 9658000.0 0.0 False True 21103129.654979825 13514489.765804656 0.0 1.0 0.6404021577252437 0.0 24.33095363484535 -7.5558748933401585 0.69369742079978 0.9949048011173907 2.9389228613465094e-15 0.9870657676410667 0.04703578688532833 0.12064148970325335 0.14465962612994251 0.042074160866189904 0.07652959391272467 2.7805141315764286e-08 7.5558748933401585 -0.9949048011173878 down AINFNFGYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AINFNFGYAK 10 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;C9J165;A0A0U1RR66 P47897 QARS Glutamine--tRNA ligase 0 98265000.0 26967000.0 32242000.0 39056000.0 False True 40910910.55177884 26488163.192104217 31336564.481147073 1.0 0.6474596344801348 0.7659708390378159 25.285982311775232 -10.912977775668985 10.99575185160531 1.0323902806311154 0.7067152367591607 0.890898813714599 0.04838199666148651 0.025519605493486638 0.00020196609227530405 0.031118445919037986 0.015615222277183347 1.22186218542365e-11 10.912977775668985 -0.3256750438719547 AINFNFGYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AINFNFGYAK 10 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;C9J165;A0A0U1RR66 P47897 QARS Glutamine--tRNA ligase 0 81413000.0 23266000.0 24529000.0 33618000.0 False True 31868068.94000888 23445227.673444156 25678120.78444326 1.0 0.735696528006746 0.8057633122603665 24.92560826522004 -10.046150880038136 5.682260167773138 1.0000008716226156 0.7707299201334938 0.9345381995080941 0.02860464489006191 3.1585483725074397e-07 5.302093212866919e-08 0.027696433557778222 0.009232109440250054 8.99185137640185e-11 10.046150880038136 -0.2292709514891218 AINFNFGYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AINFNFGYAK 10 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;C9J165;A0A0U1RR66 P47897 QARS Glutamine--tRNA ligase 0 55980000.0 21795000.0 11771000.0 22414000.0 False True 18123508.18221113 11707587.286639433 27100663.769373264 1.0 0.6459890198372767 1.4953321121334295 24.111358910279627 -6.793491489942018 1.4823137502731447 0.8030388199645836 1.5052600223407806 0.8124556222117326 0.15085311794370201 0.23018237050326873 0.9990394570082398 0.08008802748257694 0.18704347251770345 1.6088239026977137e-07 6.793491489942018 0.702221202376197 AINFNFGYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AINFNFGYAK 10 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;C9J165;A0A0U1RR66 P47897 QARS Glutamine--tRNA ligase 0 107764000.0 26967000.0 49870000.0 30927000.0 False True 34909313.09904074 47094690.66074674 25298603.337817654 1.0 1.3490580730458668 0.7246949622309476 25.05710863386768 -6.7549511017905886 1.6311801577768898 1.2040133137028834 0.7229416232005456 0.670171037139094 0.1467282224903452 0.29146646731508696 1.527167452325474 0.07101096685872817 0.17153211542907948 1.758121553743669e-07 6.7549511017905886 -0.4810716905023379 AINFNFGYAK(ub)ANNGICFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AINFNFGYAKANNGICFLR 19 1 P47897;P47897-2;A0A1B0GVU9;B4DDN1;A0A0U1RR66 P47897 QARS Glutamine--tRNA ligase 1 24638100.0 3245300.0 4699800.0 16693000.0 True False 4201104.8244267795 4438251.998543766 13655045.28464418 1.0 1.0564487638437692 3.250346243504492 22.002337353195248 -6.912423732011811 0.8790571729287576 0.9371680822312367 3.549086193998377 0.9918047355630043 0.09485236663396249 0.10283729454873326 0.13023132936427262 0.07859972092517761 0.22079625239066458 1.2234219496363308e-07 6.912423732011811 2.61191811176714 up AINQGGLTSVAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AINQGGLTSVAVR 13 0 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 29695300.0 6365700.0 9179600.0 14150000.0 False True 8345494.345526487 7810039.461800554 12685893.736384358 1.0 0.9358390454110178 1.5200889499355417 22.992566079513153 -6.879675366720485 1.0816642541518233 0.9604076616301936 1.5612282753205562 0.9734201932056811 0.04265106522489088 0.1279154410415128 0.2740578560212788 0.030384564908904288 0.07341403022593349 1.3192424982457102e-07 6.879675366720485 0.6008206136903625 AINQGGLTSVAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AINQGGLTSVAVR 13 0 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 21867700.0 8369000.0 2568700.0 10930000.0 False True 8103330.675958995 3594395.305593542 8067105.107028525 1.0 0.4435701132445962 0.9955295457659227 22.95008358374537 -10.893302288476733 10.52231327350427 1.0211421408667438 0.7195498295052597 0.25607403778500915 0.2253364947322355 0.09522978717540577 0.0009656416028490946 0.18590719688074617 0.07272704094922522 1.2784911071185535e-11 10.893302288476733 -0.3015923113614841 AINQGGLTSVAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AINQGGLTSVAVR 13 0 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 67982500.0 5060900.0 59509000.0 3412600.0 False True 7677755.3013497 48889154.00406082 2738098.1142042857 1.0 6.367636383965821 0.35662742647228485 22.872253149936896 -6.671263064861699 1.9329689909686285 4.422519201232679 0.3809118069865625 0.2845269791563284 2.279416465708789 0.45828997107763203 3.3024536618273816 0.9489518620987708 2.5311253825082534 2.1317532567323472e-07 6.671263064861699 -4.041607394246117 AINQGGLTSVAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AINQGGLTSVAVR 13 0 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 25619500.0 6365700.0 8559800.0 10694000.0 False True 8719271.31657416 8181599.732526678 8168297.449843435 1.0 0.9383352616834573 0.9368096430623282 23.055776141036045 AINQGGLTSVAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AINQGGLTSVAVR 13 0 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 12170200.0 8369000.0 1871600.0 1929600.0 False True 6959194.3095629765 1861517.3193164847 2333070.4385376405 1.0 0.2674903496743123 0.33525007849423777 22.730488859179648 -10.177216380927078 5.3356842550625725 1.0000284533558943 0.3013702141285099 0.992994209897046 0.027662793453718575 9.363511341606546e-06 1.4438656806397217e-06 0.02678547204412136 0.008928128196219437 6.649417760595853e-11 10.177216380927078 -0.6986582392273843 AINQGGLTSVAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AINQGGLTSVAVR 13 0 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 15687000.0 5060900.0 6156800.0 4469300.0 False True 6551434.815253278 5814168.667737837 3655933.2588905655 1.0 0.887464934276853 0.5580355085543544 22.643379472029345 -6.9520005200237085 0.536432344353039 1.0049671694132976 0.4254129107053799 0.9993490662329239 0.004784623300249135 0.08269225205802491 0.03271381199782505 0.005288713199853444 0.027266426861243635 1.1168619104506053e-07 6.9520005200237085 -0.5795542587079177 AINQQTGAFVEISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AINQQTGAFVEISR 14 0 A0A087WTP3;Q92945;M0R3J3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 29639400.0 6924400.0 12634000.0 10081000.0 False True 9077955.455984995 10749056.446946273 9037914.82378028 1.0 1.1840834094266832 0.9955892455741985 23.11393597855314 -6.651632804800779 2.0034510455088936 1.1193003176065102 0.9963924861042829 0.20050527351002045 0.0785379459695113 0.5044692554534493 3.8832873442602684 0.0317780710694662 0.08695898091588801 2.230320083902e-07 6.651632804800779 -0.12290783150222728 AINQQTGAFVEISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AINQQTGAFVEISR 14 0 A0A087WTP3;Q92945;M0R3J3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 32782700.0 7777100.0 8520600.0 16485000.0 False True 7530220.217469308 11922920.014342003 12167083.960600689 1.0 1.5833428067192643 1.6157673493232445 22.84426062572274 -11.44333997335915 0.4763625113350878 2.1726012238180645e-13 1.6150091870037666 0.9998176492836158 0.0038207786223372884 3.959137915684687 0.23460619690053117 4.114529737597791 0.00690950581239986 3.602964861708236e-12 11.44333997335915 1.6150091870035495 AINQQTGAFVEISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AINQQTGAFVEISR 14 0 A0A087WTP3;Q92945;M0R3J3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 67302000.0 11623000.0 39755000.0 15924000.0 False True 17632940.755120173 32660409.642767303 12776614.420262853 1.0 1.8522383813535765 0.7245878380526424 24.0717697661541 -6.704561676128592 1.8145577358443 1.5268228046788883 0.7276351427369703 0.43926220692828655 0.3594493332681057 0.38611242693654074 2.4746511421849426 0.1578466209675752 0.40367627191660194 1.974414463947674e-07 6.704561676128592 -0.799187661941918 AINQQTGAFVEISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AINQQTGAFVEISR 14 0 A0A087WTP3;Q92945;M0R3J3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 25830700.0 6924400.0 7543300.0 11363000.0 False True 9484537.804873964 7210012.063642671 8679293.428330917 1.0 0.7601859164858358 0.9150992496303569 23.177146040076032 -10.679235348604866 5.698375196070796 1.0024134305168455 0.8376425830580964 0.5942470800671655 0.06324310342630969 0.0019659729555934237 0.00011066561808836846 0.062083411074575455 0.020411623861047546 2.0929779424036535e-11 10.679235348604866 -0.16477084745874915 AINQQTGAFVEISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AINQQTGAFVEISR 14 0 A0A087WTP3;Q92945;M0R3J3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 16554400.0 7777100.0 4918000.0 3859300.0 False True 6467003.233946967 4891505.757853429 4666261.786612932 1.0 0.7563790492908143 0.7215493201114421 22.624665901157016 -13.999999999999998 0.27398452209200863 2.9212375950668283 0.710427277791517 0.999591954899506 0.0025022288829567017 15.082171721668011 0.16573626940187383 16.178447566163072 0.014183094040358049 1.0000000000000041e-14 13.999999999999998 -2.2108103172753113 AINQQTGAFVEISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AINQQTGAFVEISR 14 0 A0A087WTP3;Q92945;M0R3J3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 44172000.0 11623000.0 18750000.0 13799000.0 False True 15046202.623582555 17706546.017425355 11287723.58969658 1.0 1.1768116155549526 0.7502041459952726 23.84289608824655 -6.79413917949425 1.4796321242124977 1.098292396271243 0.7451278865509761 0.8144786540399555 0.07538032979417607 0.22924398574692834 0.9913243956640168 0.040089766234890016 0.09358999945032309 1.6064263548351337e-07 6.79413917949425 -0.3531645097202669 AINVFVSANR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AINVFVSANR 10 0 Q9BUL8;C9J363;C9J5C3 Q9BUL8 PDCD10 Programmed cell death protein 10 0 17549300.0 4888700.0 7910100.0 4750500.0 False True 6409133.042238139 6729943.913328301 4258963.830013711 1.0 1.0500552678460442 0.664514810653148 22.61169778728298 -6.874248918565388 1.1113110640729158 1.0291882611410672 0.640028395872047 0.9687458412763568 0.030261153221398877 0.13284933975305185 0.30407462468378144 0.021072576188282642 0.05029501113245195 1.3358296580678294e-07 6.874248918565388 -0.38915986526902024 AINVFVSANR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AINVFVSANR 10 0 Q9BUL8;C9J363;C9J5C3 Q9BUL8 PDCD10 Programmed cell death protein 10 0 23839700.0 10955000.0 5427700.0 7457000.0 False True 10607239.521463815 7595008.915081576 5503787.9947952265 1.0 0.7160212513079419 0.5188709073325135 23.338545915481575 -7.88405172440472 0.1240245445262782 1.4105722980512474 4.7666956349081414e-11 0.9999814882382493 0.0008496587612341195 0.12220794735775492 0.018305583156616557 0.08610542840079287 0.10796160811797144 1.306015332647306e-08 7.88405172440472 -1.4105722980035804 AINVFVSANR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AINVFVSANR 10 0 Q9BUL8;C9J363;C9J5C3 Q9BUL8 PDCD10 Programmed cell death protein 10 0 17573300.0 4888700.0 4306800.0 8377800.0 False True 6696184.502149972 4116511.335316936 6399136.186207058 1.0 0.614754765791658 0.9556391679698283 22.674907848805873 -10.246768177175301 7.8404002108802855 1.0000002669325079 0.7851969668807431 0.3461599474665349 0.13916547443503396 6.493875033541144e-07 6.235898958636673e-08 0.13474655886828957 0.04491546373782836 5.6654162360113614e-11 10.246768177175301 -0.21480330005176473 AINVFVSANR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AINVFVSANR 10 0 Q9BUL8;C9J363;C9J5C3 Q9BUL8 PDCD10 Programmed cell death protein 10 0 39095000.0 14498000.0 24597000.0 0.0 False True 18767946.798305076 23228155.327499274 0.0 1.0 1.2376503182328393 0.0 24.161767493073683 -6.902336832488316 1.2937904619733276 1.123872083049516 3.58373461560262e-21 0.9484586600527307 0.12174754446815454 0.1329875603601098 0.4466605156443583 0.07691719579631948 0.15292905647322844 1.2521696336640927e-07 6.902336832488316 -1.123872083049516 down AINVLLEGNPDTHSWEMVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AINVLLEGNPDTHSWEMVGK 20 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77;Q5VU81;Q5VU80;Q5VU79;Q5VU78 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 4142800.0 0.0 2232200.0 1910600.0 False True 0.0 1899164.4610474517 1712909.439769327 0.0 AINVLLEGNPDTHSWEMVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AINVLLEGNPDTHSWEMVGK 20 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77;Q5VU81;Q5VU80;Q5VU79;Q5VU78 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 40357000.0 6802700.0 27222000.0 6332300.0 False True 10320193.243986571 22364021.41354321 5080718.129454314 1.0 2.1670157607343645 0.4923084296328245 23.298966649462134 -6.719305837079918 1.761790317410891 1.7104967221180847 0.4950070546710923 0.5093455507702016 0.49112262130818934 0.35661916883989064 2.1628890963672758 0.22137480974515794 0.5561925902373587 1.9085087829888847e-07 6.719305837079918 -1.2154896674469924 AINVLLEGNPDTHSWEMVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AINVLLEGNPDTHSWEMVGK 20 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77;Q5VU81;Q5VU80;Q5VU79;Q5VU78 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 3682800.0 0.0 0.0 3682800.0 False True 0.0 0.0 2812998.489646848 0.0 AINVLLEGNPDTHSWEMVGKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 AINVLLEGNPDTHSWEMVGKK 21 1 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77;Q5VU81;Q5VU80;Q5VU79;Q5VU78 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 1 16258900.0 3920100.0 6621400.0 5717400.0 True False 3795658.571254255 9265359.550144836 4219841.421676579 1.0 2.441041357174323 1.1117547435996475 21.85591879358206 -6.627067071215024 2.091442986523151 1.9514327270924996 1.1170787102771949 0.10687652643116352 0.6185975603525627 0.5667181394465384 4.72013987891024 0.2422557707593734 0.685264992690352 2.360113715727315e-07 6.627067071215024 -0.8343540168153047 AINVLLEGNPDTHSWEMVGKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 AINVLLEGNPDTHSWEMVGKK 21 1 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77;Q5VU81;Q5VU80;Q5VU79;Q5VU78 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 1 33309400.0 5577600.0 20659000.0 7072800.0 True False 8461626.977179583 16972240.040496252 5674857.979881632 1.0 2.005789204164778 0.6706580182731202 23.012503656574207 -6.705152334284806 1.8123426173819535 1.621366462075315 0.6741994877034851 0.4421410661379287 0.4241686118850988 0.38489249618702726 2.4611760032140424 0.186462914301407 0.47653427271688537 1.9717310052061901e-07 6.705152334284806 -0.9471669743718298 AINVLLEGNPDTHSWEMVGKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AINVLLEGNPDTHSWEMVGKK 21 1 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77;Q5VU81;Q5VU80;Q5VU79;Q5VU78 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 1 11403100.0 3920100.0 4638600.0 2844400.0 True False 3259736.8398754722 4613610.941109988 3439150.8889803444 1.0 1.4153323313320705 1.0550394273887846 21.636324069016336 -10.38327203151205 6.367462724131091 0.9999721760431067 1.2351858793604276 0.3622988762058824 0.14708896210110733 5.810581637571877e-05 5.62789512722902e-06 0.1424350993394881 0.04747275838571022 4.1374043668047674e-11 10.38327203151205 0.23521370331732083 AINVLLEGNPDTHSWEMVGKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AINVLLEGNPDTHSWEMVGKK 21 1 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77;Q5VU81;Q5VU80;Q5VU79;Q5VU78 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 1 35681400.0 5577600.0 21550500.0 8553300.0 True False 7220313.150932984 20351195.73058801 6996687.164269273 1.0 2.818602920007465 0.9690282149833328 22.783629978666657 -6.650005727301225 2.008208371902136 2.1800593390948655 0.976751139594251 0.19421741620896582 0.7761925673199733 0.5084988148622941 3.930687800492623 0.3134388037447148 0.8598957445374716 2.238691615407653e-07 6.650005727301225 -1.2033081995006145 AIPQLQGYLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIPQLQGYLR 10 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 169450000.0 47463000.0 53447000.0 68540000.0 False True 62224452.63234579 45472915.9347743 61448138.28210496 1.0 0.7307885246247449 0.9875239665854886 25.890978298568935 -10.613783832638438 8.675758431448054 1.0000628086447767 0.8591562456649422 0.28636428185600415 0.10481180528195795 0.00012738903940085343 5.67098650603882e-06 0.10152869206072576 0.033827864695246464 2.4334149247421023e-11 10.613783832638438 -0.1409065629798345 AIPQLQGYLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIPQLQGYLR 10 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 95904000.0 37633000.0 11459000.0 46812000.0 False True 36438361.01426275 16034638.45789556 34550532.870102465 1.0 0.4400482900869021 0.9481911894055457 25.118954732852792 -10.48581500765039 9.018006524887326 1.000007057125407 0.6941197397462248 0.3257532602837193 0.2074484699581871 2.943471790867365e-05 1.6784886931636195e-06 0.2008657463516854 0.06695370577868905 3.267269753626019e-11 10.48581500765039 -0.3058873173791822 AIPQLQGYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIPQLQGYLR 10 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 108492000.0 24740000.0 65016000.0 18736000.0 False True 37532388.73627062 53413386.827673405 15032821.387719464 1.0 1.4231278270880658 0.4005292999960862 25.161632777199618 -6.794330638443576 1.4788192059687113 1.2351709037447471 0.38829592478415403 0.8150635845735197 0.18041915073691153 0.22897703822289686 0.9890651577688365 0.09600322779313518 0.22409541631406588 1.605718317017914e-07 6.794330638443576 -0.8468749789605932 down AIPQLQGYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIPQLQGYLR 10 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 127941000.0 47463000.0 33339000.0 47139000.0 False True 65011353.7393467 31865972.742670074 36005739.0581793 1.0 0.4901601168071646 0.5538377066033562 25.954188360091827 -10.326097940630715 5.718970136404544 1.0000668964594523 0.5219989117057501 0.9868648681519543 0.025996267175164043 2.2176541668766223e-05 2.6132083724071735e-06 0.0251742802540693 0.008390259152745995 4.719565951975414e-11 10.326097940630715 -0.47806798475370227 AIPQLQGYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIPQLQGYLR 10 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 80735000.0 37633000.0 21267000.0 21835000.0 False True 31293506.92457684 21152430.449830994 26400597.546366796 1.0 0.6759367207009517 0.8436445812863714 24.89936000828707 -10.099465057952507 4.69421811266954 1.0000142325397485 0.7597906509896698 0.7322869298900386 0.06846644739503287 95312079.49638283 1.6817866100039205 14662.532113365602 0.02343788604200784 7.953072510247794e-11 10.099465057952507 -0.24022358155007872 AIPQLQGYLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIPQLQGYLR 10 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 77625000.0 24740000.0 32064000.0 20821000.0 False True 32026417.6983079 30279610.21347877 17031791.641501002 1.0 0.9454572939975918 0.5318044559944919 24.932759099292067 -6.931104572814486 0.7376762283774879 1.0060399203787522 0.4444466973834876 0.9967507437009193 0.011915917483616026 0.09206866682631044 0.07490216528011448 0.010928107543014627 0.037203827207620235 1.1719131491789666e-07 6.931104572814486 -0.5615932229952647 AIQFLHQDSPSLIHGDIK(ub)SSNVLLDER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIQFLHQDSPSLIHGDIKSSNVLLDER 27 1 D3YTB5;P51617-4;P51617-2;P51617-3;P51617;H7C224 D3YTB5 IRAK1 Interleukin-1 receptor-associated kinase 1 1 18602400.0 3551300.0 6727900.0 8323200.0 True False 2953063.2992652664 6691655.467316411 10063542.637871325 1.0 2.2660047513987664 3.4078316710566865 21.493780850468355 -6.972351605268977 0.1939589713528655 0.26504941865575116 5.4401097376256615 0.9999953859104467 0.002112439680062589 0.07554675065509342 0.006216863378412115 0.03898210111925216 0.12313795691110438 1.065732953347515e-07 6.972351605268977 5.17506031896991 AIQGGTSHHLGQNFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIQGGTSHHLGQNFSK 16 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 29645200.0 5742700.0 9673400.0 14229100.0 False True 7528735.312385899 8230166.426617878 12756809.22716515 1.0 1.0931671901226252 1.694415954055163 22.843976108618918 -6.9343131664471 0.7104951732064588 0.992155294943195 1.832599452855657 0.9973201564126802 0.01593138600970713 0.09045914883148326 0.0671562684904871 0.014906557195377671 0.05317156948188606 1.1632868895715558e-07 6.9343131664471 0.8404441579124621 AIQGGTSHHLGQNFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIQGGTSHHLGQNFSK 16 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 13001590.0 2407400.0 1732090.0 8862100.0 False True 2330978.4047441357 2423722.5697300215 6540850.152698765 1.0 1.0397876551739509 2.8060535178646298 21.15250420806257 -6.9117569437615405 0.8836892575255407 0.9483048821586396 3.043101175625622 0.9915677856720766 0.07733313931169686 0.10326751245947899 0.1325515463867821 0.06386890988685984 0.17852795870196098 1.2253017569364433e-07 6.9117569437615405 2.0947962934669824 up AIQGGTSHHLGQNFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIQGGTSHHLGQNFSK 16 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 19634700.0 5742700.0 6147000.0 7745000.0 False True 7865931.380632198 5875405.214589309 5915790.513281965 1.0 0.746943359950477 0.7520775642472618 22.90718617014181 -10.117767824486894 7.366660236950836 1.000000079375214 0.7495104620989185 0.9996850113916987 0.0020960301270546576 2.733396018101491e-09 3.284149382249061e-10 0.002029473109117264 0.0006764908146026356 7.624865293385572e-11 10.117767824486894 -0.2504896172762955 AIQGGTSHHLGQNFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIQGGTSHHLGQNFSK 16 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 8584890.0 1904790.0 3482600.0 3197500.0 False True 2465788.204024248 3288790.2485485594 2615587.8091205726 1.0 1.3337683435994807 1.0607512051731964 21.23361745579394 -10.425132419783944 9.826190970627733 0.9999995571263162 1.1972597743863385 0.41039225636606924 0.11145878002986641 1.0813304094304617e-06 6.325374981331016e-08 0.1079197409196438 0.0359731665703557 3.7572282599342674e-11 10.425132419783944 0.1972602172600223 AIQLEYSEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIQLEYSEAR 10 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 15098800.0 3603300.0 3931600.0 7563900.0 False True 4723961.194406838 3345020.6052567638 6781260.186052134 1.0 0.7080965460125418 1.435502940642513 22.171565682902013 -6.7977887048234935 1.4648606070260901 0.8384864748070326 1.445011240829473 0.8256257038306625 0.12480886606677562 0.22393574675948147 0.9488783917249298 0.06703426058327198 0.1561160704048211 1.592983565072766e-07 6.7977887048234935 0.6065247660224404 AIQLEYSEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIQLEYSEAR 10 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 8510300.0 2764000.0 1526900.0 4219400.0 False True 2676258.332937104 2136599.132678311 3114212.560713285 1.0 0.798353098571566 1.1636442276092012 21.351785951992248 -6.756866301810204 1.6244360877946424 0.8824158544138581 1.1647681532039533 0.6779781350391714 0.08477897658687195 0.2882142688636553 1.4982248770944018 0.04119430597366872 0.09929844589138784 1.7503854644075998e-07 6.756866301810204 0.28235229879009527 AIQLEYSEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIQLEYSEAR 10 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 11010800.0 3603300.0 3583600.0 3823900.0 False True 4935537.385521104 3425264.7026195265 2920773.575692564 1.0 0.6940003560033575 0.5917843078771822 22.234775744424905 -13.999999999999998 0.1531864165238782 2.4873681637552885 0.48334437950592235 0.9995559538427091 0.003654732572009708 11.971112567455153 0.1234187331270049 5.2956290748409245 0.09805707105911851 1.0000000000000041e-14 13.999999999999998 -2.004023784249366 AIQLNSNSVQALLLK(ub)GAALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIQLNSNSVQALLLKGAALR 20 1 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 14018700.0 1327300.0 1846400.0 10845000.0 True False 1285165.588027287 2583677.148848799 8004369.156973868 1.0 2.0103846328586426 6.228278465859386 20.293522825735522 -6.943894302910185 0.6222793449010927 0.953900497661866 7.50909481739105 0.9986307827905012 0.08378838847735598 0.086034072764216 0.046850480651236225 0.08420667256590604 0.35727098914185057 1.1379041913146937e-07 6.943894302910185 6.555194319729184 AIQLNSNSVQALLLK(ub)GAALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIQLNSNSVQALLLKGAALR 20 1 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 53074900.0 5275900.0 10598000.0 37201000.0 True False 8003926.019955127 8706704.097448051 29848206.04422249 1.0 1.0878041695713805 3.72919564346371 22.93227640184305 -6.913967946358974 0.8682773186468388 0.928117032661569 4.101189271244938 0.9923346407152003 0.11087300696651836 0.10185271572837941 0.124967714010144 0.09259269255620275 0.26320217592759565 1.2190795712791096e-07 6.913967946358974 3.1730722385833694 up AIQLNSNSVQALLLK(ub)GAALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIQLNSNSVQALLLKGAALR 20 1 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 10737800.0 1327300.0 2775000.0 6635500.0 True False 1103708.7593598913 2760050.5242056297 8022952.370914438 1.0 2.500705463102742 7.269084622982826 20.0739281011698 -6.950152144948102 0.5571702226446598 0.9366876558863968 9.059886967438757 0.9992131732949876 0.0749710007938194 0.08342469386735889 0.03570988706488616 0.08064210801618782 0.39614235331109693 1.1216254501352837e-07 6.950152144948102 8.12319931155236 AIQQAVGSSLQGDLPNDK(ub)DGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIQQAVGSSLQGDLPNDKDGSR 22 1 Q9H7N4;M0R3G4;M0R2L3;M0R232 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 58866000.0 13822000.0 25080000.0 19964000.0 True False 18120775.852438383 21338161.76107433 17898316.78821043 1.0 1.177552326392416 0.9877235353475211 24.111141390815487 -6.661238484288217 1.96861577635167 1.1141735113128672 0.9885155637319276 0.24080678927708976 0.07557583350607486 0.48153173865602156 3.5887364634874666 0.031003100027482983 0.0837849536867896 2.181531637600033e-07 6.661238484288217 -0.12565794758093962 AIQQAVGSSLQGDLPNDK(ub)DGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIQQAVGSSLQGDLPNDKDGSR 22 1 Q9H7N4;M0R3G4;M0R2L3;M0R232 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 87719000.0 23132000.0 27111000.0 37476000.0 True False 22397687.32181664 37936563.68199732 27659911.344098955 1.0 1.6937714656389955 1.234944972071139 24.41684643838748 -10.207214358334845 3.947381584781672 0.9996586504019981 1.4643582189727637 0.5772880446160927 0.18731513199610877 18521753.528250575 7982421.985807787 53004.29349908713 0.06412295262072347 6.205626623591433e-11 10.207214358334845 0.46469956857076566 AIQQAVGSSLQGDLPNDK(ub)DGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIQQAVGSSLQGDLPNDKDGSR 22 1 Q9H7N4;M0R3G4;M0R2L3;M0R232 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 51840000.0 13822000.0 17168000.0 20850000.0 True False 18932366.92550512 16409460.993015954 15925659.419229047 1.0 0.8667411242125049 0.8411869198338044 24.174351452338378 -13.999999999565796 0.23221318688847664 1.8499317484283104 0.829021023274348 0.9995128884609427 0.0015367213925977924 13.36138316043196 0.1525656509216293 5.242533423702438 0.013084852284855343 1.0000000009997911e-14 13.999999999565796 -1.0209107251539624 AIQQAVGSSLQGDLPNDK(ub)DGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIQQAVGSSLQGDLPNDKDGSR 22 1 Q9H7N4;M0R3G4;M0R2L3;M0R232 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 76947000.0 23132000.0 28825000.0 24990000.0 True False 19235282.9213539 28669714.003685474 30215293.459295034 1.0 1.490475295887539 1.570826568178613 24.197251713821757 -11.755832913451197 0.30117878336996745 2.6943281522420585e-13 1.5925504525012892 0.9994321359595708 0.006012111034971267 4.54112415560915 0.16312668897045865 2.914446758243413 0.028852300606705013 1.754555403854537e-12 11.755832913451197 1.59255045250102 AIRLELQGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIRLELQGPR 10 1 P19338;H7BY16 P19338 NCL Nucleolin 0 20746300.0 11719000.0 7699900.0 1327400.0 False True 16051830.994067058 7359692.9578357255 1013895.4586611326 1.0 0.4584955423811746 0.06316385084267832 23.9362345357271 -8.171521425471962 0.4476721711845785 1.0520350702835122 5.312055999017105e-19 0.9956812220304866 0.025236171154831104 0.10619915642228135 0.11947372655815308 0.0559639038178569 0.07886198317846053 6.7371865743309e-09 8.171521425471962 -1.0520350702835122 AIRPQIDLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIRPQIDLKR 10 2 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 47831160.0 603160.0 14700000.0 32528000.0 True False 915037.8169025442 12076670.148375789 26098826.542471148 1.0 13.198001137544253 28.522128878582507 19.80347184311256 -7.2671649427074225 0.3766303922472617 2.2325481511975515e-15 37.65843989829808 0.9992628302094434 0.30571871259818384 0.13346887600085108 0.036918922610735226 0.5323624098852713 2.396494118493669 5.405489863586916e-08 7.2671649427074225 37.65843989829808 AIRPQIDLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIRPQIDLKR 10 2 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 37346160.0 603160.0 12496000.0 24247000.0 True False 780802.5100610895 11800586.615133185 19834294.795229554 1.0 15.113407632629041 25.402447532702897 19.57459816520501 -8.032027369667532 0.40758212103390995 1.2209095729638376e-18 28.520934110211655 0.996119804921192 0.6230962184953872 0.1111587487909941 0.10528647269551182 1.489446225477813 2.514760361914243 9.289078442447206e-09 8.032027369667532 28.520934110211655 AISEPNFSVAYANMCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AISEPNFSVAYANMCR 16 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 10637900.0 3091200.0 4136400.0 3410300.0 False True 4052593.135223386 3519265.243560916 3057434.869907535 1.0 0.8683983627601264 0.7544391375817213 21.95041391094137 -6.972807998420929 0.1788383247110587 1.0894645104978076 0.5302949563016478 0.9999968074652709 0.00017918403628186546 0.07540180598368591 0.0056326172019095485 0.004433862221343019 0.012834220346642325 1.0646135798347672e-07 6.972807998420929 -0.5591695541961598 AISEPNFSVAYANMCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AISEPNFSVAYANMCR 16 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 10506600.0 3091200.0 2766100.0 4649300.0 False True 4234100.176538963 2643884.5557305166 3551231.0953391693 1.0 0.6244265476712646 0.8387215576562045 22.013623972464263 -10.179783859660978 5.354595971468247 1.000010886755106 0.731574052663668 0.6765857056817273 0.08748557148152145 1.1370443099845948e-05 1.7417169371255848e-06 0.08471097344978956 0.028235846781747224 6.610223447649215e-11 10.179783859660978 -0.26843683409143804 AISHEHSPSDLEAHFVPLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AISHEHSPSDLEAHFVPLVK 20 0 P30153;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0 11328200.0 1684600.0 4753300.0 4890300.0 False True 2208526.913689604 4044126.1682182816 4384298.6670699995 1.0 1.8311418996756046 1.9851687746677775 21.074652982870425 -10.97082227727489 0.31763384964543917 1.51325098489762e-13 2.0232600989430045 0.9992705846806885 0.011686278192425749 2.8090317179154463 0.1606643228350435 2.1161321865883735 0.05156144055387836 1.0694924492005401e-11 10.97082227727489 2.023260098942853 AISHEHSPSDLEAHFVPLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AISHEHSPSDLEAHFVPLVK 20 0 P30153;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0 10227000.0 1684600.0 5067000.0 3475400.0 False True 2307442.1446032366 4843123.18567171 2654582.098109764 1.0 2.0989142445018847 1.15044362187734 21.137863044393317 -6.610432551428467 2.1521422154027743 1.7339834714590538 1.153849141300677 0.05168304247121558 0.4737281910439748 0.6114947979846155 5.367727238457466 0.18173400506298532 0.5258845810349413 2.4522652759324915e-07 6.610432551428467 -0.5801343301583768 AISHEHSPSDLEAHFVPLVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 AISHEHSPSDLEAHFVPLVKR 21 1 P30153;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 48753000.0 2968100.0 9985900.0 35799000.0 True False 4502824.697175614 8203838.124807184 28723311.958740916 1.0 1.821931493347503 6.378954076706017 22.102398881461312 -6.937528989885286 0.6821629238446753 0.9460063918754171 7.523377055955481 0.997822027143139 0.11041123106731224 0.0889122006557615 0.05987980118810291 0.1055623357921968 0.39667238475181615 1.1547049036272676e-07 6.937528989885286 6.577370664080064 AISHEHSPSDLEAHFVPLVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AISHEHSPSDLEAHFVPLVKR 21 1 P30153;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 74535000.0 2968100.0 11029900.0 60537000.0 True False 3842263.9599978803 10416076.36893866 49519887.16207413 1.0 2.710921601790317 12.888205411608796 21.87352520355376 -6.936017605070511 0.6956226484485634 0.8741813358312722 15.338471867340532 0.9975944108251281 0.2573769983221721 0.08963125603614892 0.06323992890137092 0.2435369835457467 0.892381156911082 1.1587303835491397e-07 6.936017605070511 14.46429053150926 AISTICSLEKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 AISTICSLEKK 11 1 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 29679500.0 4128600.0 7696900.0 17854000.0 True False 6263388.041090005 6323328.058845815 14325149.074313803 1.0 1.0095699032795962 2.287124632920049 22.578511831567862 -6.908541824131904 0.9056048199090037 0.9585970863310231 2.447180820119154 0.9903596239522487 0.05935439467899502 0.10539026690536248 0.14405512718254673 0.04824656608582334 0.13187491896754008 1.2344064316351368e-07 6.908541824131904 1.4885837337881307 up AISTICSLEKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AISTICSLEKK 11 1 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 6263400.0 1706400.0 1202300.0 3354700.0 True False 1418947.206337468 1195822.9712621341 4056152.2596197226 1.0 0.8427536739360068 2.858564604450159 20.436389482491478 -6.88805424064554 1.033860327053797 0.8865813622644375 3.025452307052419 0.9796220545862457 0.13068209791864827 0.12073457218585103 0.2312012744931739 0.09655173671857543 0.23907122962151825 1.2940342146337173e-07 6.88805424064554 2.1388709447879815 up AISYHLVQKPFSLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AISYHLVQKPFSLTK 15 1 Q969Z0;C9IZN7;C9J7P5 Q969Z0 TBRG4 Protein TBRG4 0 7818000.0 2698300.0 2162500.0 2957200.0 False True 3537497.4303743676 1839863.4293589804 2651217.311465433 1.0 0.5201031140153424 0.7494612684947898 21.754297669300495 -10.273244760450032 6.208477656231305 1.000011233317744 0.6347821912550657 0.7717290721622881 0.09363507447018214 1.4559626817578755e-05 1.7041315906129272e-06 0.09066455844420664 0.030220590336992058 5.330344023508134e-11 10.273244760450032 -0.36522904206267826 AISYHLVQKPFSLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AISYHLVQKPFSLTK 15 1 Q969Z0;C9IZN7;C9J7P5 Q969Z0 TBRG4 Protein TBRG4 0 10005100.0 2698300.0 3214400.0 4092400.0 False True 3695934.4288156913 3072377.1794006606 3125859.4056236465 1.0 0.8312856298116629 0.8457561858383085 21.817507730823387 -10.510849884958683 6.155185165992106 1.0001575095051676 0.8385209078249857 0.9940132422084533 0.005907579759939661 1.2781463617396606e-05 1.0157419064491473e-06 0.005725540501513048 0.001906663168886525 3.0842538465587834e-11 10.510849884958683 -0.1616366016801819 AISYHLVQKPFSLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AISYHLVQKPFSLTK 15 1 Q969Z0;C9IZN7;C9J7P5 Q969Z0 TBRG4 Protein TBRG4 0 6914300.0 1962400.0 2802200.0 2149700.0 False True 1631822.5490603868 2787103.9924068497 2599192.33091022 1.0 1.7079700203993877 1.5928155499547731 20.638052750708507 -10.18942040737096 4.4312295781400195 0.9998338254650795 1.6503927851926647 0.9770290517426737 0.04701161575134527 5250706.242034232 12073793.300582381 5166.897323478134 0.016093326547984812 6.465164694410477e-11 10.18942040737096 0.6505589597275853 AITGASLADIMAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AITGASLADIMAK 13 0 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 17769500.0 2811300.0 8353500.0 6604700.0 False True 3685641.524667928 7107190.361687965 5921309.000756037 1.0 1.9283455306544806 1.6065884218866187 21.813484326745936 -10.018661916389403 4.978873250213799 0.9999917700524794 1.7674669762767152 0.8835287212159677 0.13135678963083997 90699321.11050564 3.705153079135072 10376.567159449201 0.044966922971571094 9.57939504714372e-11 10.018661916389403 0.7674752062242358 AITGASLADIMAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AITGASLADIMAK 13 0 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 16696300.0 4939400.0 2498800.0 9258100.0 False True 4782601.450690859 3496583.8710698527 6833125.872953417 1.0 0.7311050078330826 1.4287466650532534 22.18936414131558 -6.802219670962984 1.4469373667864422 0.8520548545473692 1.438901722571371 0.8385481992861186 0.11543713063490603 0.2176033265062185 0.8991986769571164 0.06275769617820443 0.14575157796234614 1.5768134982095793e-07 6.802219670962984 0.5868468680240018 AITGASLADIMAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AITGASLADIMAK 13 0 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 15630300.0 2811300.0 6803600.0 6015400.0 False True 3850713.5825258736 6502994.455503467 4594686.411051817 1.0 1.688776460813227 1.1932038861321737 21.876694388268827 -10.357409537629303 5.942351292629347 0.9999330222355985 1.4409901734727009 0.5135715745846424 0.20231665641431681 0.00017955093345419285 1.9416328132826004e-05 0.1959218462899097 0.06529742007941784 4.391273251541561e-11 10.357409537629303 0.4410571512371023 AITGASLADIMAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 2 AITGASLADIMAKR 14 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 211867200.0 32720100.0 66747100.0 112400000.0 True False 42896367.961899094 56788692.858158015 100769926.21693303 1.0 1.3238578359034545 2.3491482147495026 25.354352164030004 -6.950235137222752 0.5562586598474137 0.9863186570074459 2.7353738077926866 0.9992195899787525 0.016064931015034825 0.08339151486159291 0.03557303118696835 0.017299558935780585 0.08516179161674498 1.1214111316080698e-07 6.950235137222752 1.7490551507852405 up AITGASLADIMAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 2 AITGASLADIMAKR 14 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 509077600.0 107038600.0 179127000.0 222912000.0 True False 103640718.23296742 250653345.2349645 164524659.98334348 1.0 2.4184832902405855 1.587451947346784 26.62701567767966 -9.973767448154438 5.227485246378421 0.9999971377521246 2.0029676187789236 0.6601099110964495 0.33926712507903944 1.7127935896341498e-05 3.362589648699808e-06 0.32849539993981286 0.10949799377590243 1.0622642159935447e-10 9.973767448154438 1.002970481026799 AITGASLADIMAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 AITGASLADIMAKR 14 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 651550000.0 142530000.0 360070000.0 148950000.0 True False 216228430.33874875 295812695.26024956 119509967.21289581 1.0 1.3680564336374368 0.5527023760273733 27.687980984355246 -6.78395380790309 1.5201704537066278 1.2073296537062799 0.545388906647814 0.7812386458021122 0.1559331681711591 0.24447118390582406 1.1160385368486752 0.08076681841793003 0.1899795503184493 1.6445466299216544e-07 6.78395380790309 -0.6619407470584658 AITGASLADIMAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AITGASLADIMAKR 14 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 210365900.0 32720100.0 53342100.0 124303700.0 True False 44817605.1974548 50985269.643264055 94945726.17506105 1.0 1.1376170015920333 2.118491734593017 25.417562225552896 -6.932309988851878 0.7275827250748691 0.9862879354633832 2.332240186156119 0.9969730840431015 0.02739892642883063 0.09145589843262078 0.07193373243435114 0.025313995203702075 0.08765204775432456 1.1686649286074153e-07 6.932309988851878 1.345952250692736 up AITGASLADIMAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AITGASLADIMAKR 14 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 385916700.0 107038600.0 196594400.0 82283700.0 True False 89007338.51399063 195535306.94626704 99488841.23315695 1.0 2.1968447794395267 1.117759983549208 26.407420953113935 -6.621360439637164 2.111486315361237 1.7933692653082443 1.1218880997070158 0.08744860010988487 0.5145034558217269 0.5817847406001768 4.930589910197434 0.20007379345197218 0.5704975703445433 2.3913302649373144e-07 6.621360439637164 -0.6714811656012285 AITGASLADIMAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AITGASLADIMAKR 14 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 497982000.0 142530000.0 326660000.0 28792000.0 True False 184507894.6863306 308481083.8427822 23552151.43086775 1.0 1.6719126537496407 0.12764847526392933 27.459107306447695 -6.788458292551478 1.5025296399064159 1.3762928367978304 0.11193089996024351 0.7962560384913387 0.2853673980209645 0.23767115076368334 1.060034950204922 0.14950691637282737 0.3504230730281166 1.627577612470524e-07 6.788458292551478 -1.264361936837587 AITHLNNNFMFGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AITHLNNNFMFGQK 14 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 142726600.0 58835800.0 61992400.0 21898400.0 False True 77134303.56669769 52743375.564482525 19632563.632285472 1.0 0.6837862419912246 0.25452441682200816 26.200869269868 -7.233464406904478 0.37916583693856437 1.0364459168396234 3.56328978210854e-13 0.999709264840053 0.005209121601434367 0.09348032919963165 0.02523967918843109 0.00976486429903731 0.045900836673787325 5.841650810410244e-08 7.233464406904478 -1.036445916839267 down AITHLNNNFMFGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AITHLNNNFMFGQK 14 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 146522600.0 56621000.0 18396900.0 71504700.0 False True 54823597.34776848 25742878.10856614 52775473.974981055 1.0 0.46955835359121995 0.9626415727556997 25.708293660480127 -10.580522354343888 9.419788331434349 1.0000317522727893 0.7160999631734599 0.30652211063901347 0.20130038128031716 0.00013424907035690953 5.978220668781586e-06 0.19492996252767092 0.06496941869032272 2.627106298526697e-11 10.580522354343888 -0.28393178909932937 AITHLNNNFMFGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AITHLNNNFMFGQK 14 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 159638900.0 24042300.0 106877000.0 28719600.0 False True 36473926.82756824 87803964.31618753 23043158.47175215 1.0 2.4073076839596634 0.6317707051584954 25.12036219455971 -6.695487859318226 1.846826639552848 1.8777364752311287 0.6374657224803061 0.3961602472690794 0.5945506097885649 0.40503746682334374 2.68249641473298 0.2571349895630559 0.6650244859435576 2.0161003298663036e-07 6.695487859318226 -1.2402707527508228 AITHLNNNFMFGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AITHLNNNFMFGQK 14 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 215422100.0 58835800.0 92829000.0 63757300.0 False True 80588985.23771057 88727507.83554745 48699138.86281111 1.0 1.1009880267611134 0.6042902602528737 26.264079331390892 -6.85375951825897 1.216803739000316 1.0541167228431068 0.5829453108677961 0.9456023345628449 0.049992308431384413 0.15336756002960228 0.43508705035714185 0.032115141995772076 0.07451783375538515 1.400362530209655e-07 6.85375951825897 -0.47117141197531065 AITHLNNNFMFGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AITHLNNNFMFGQK 14 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 110336400.0 56621000.0 30284000.0 23431400.0 False True 47082870.23560347 30120854.08109664 28330797.405447207 1.0 0.6397412462403287 0.6017219694483243 25.488698935914403 -13.999999999999998 0.31767103696012194 4.643206913522013 0.5939762729737872 0.9996887144176244 0.0031662819956938407 17.834507050477985 0.17964347139789597 43.12900880602199 0.01277451324912567 1.0000000000000041e-14 13.999999999999998 -4.049230640548226 AITHLNNNFMFGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AITHLNNNFMFGQK 14 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 115454200.0 24042300.0 55681900.0 35730000.0 False True 31123231.29458477 52583153.316676095 29227506.62075938 1.0 1.6895145886033114 0.9390897218903091 24.89148851665216 -6.665179628582232 1.9553825585717242 1.441942776150188 0.942235712340941 0.25757046417141494 0.29322306737893805 0.47222595448765375 3.4764224959599694 0.12095256690630178 0.3250910228176866 2.161824186477608e-07 6.665179628582232 -0.499707063809247 AITIAGIPQSIIECVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AITIAGIPQSIIECVK 16 0 Q15366-3;Q15366-2;F8VZX2;F8VXH9;Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 28577600.0 5389000.0 20812000.0 2376600.0 False True 7065031.187150245 17706930.724540588 2130692.229956967 1.0 2.5062777863947217 0.30158284847096395 22.752264498382708 -6.722770458977995 1.7492630868464463 1.9136653854137822 0.3044446175954052 0.5256224735300479 0.6336397907517648 0.3499477190618624 2.0941462058887805 0.2874494615297434 0.7192876472491547 1.8933440580176518e-07 6.722770458977995 -1.609220767818377 AITIAGIPQSIIECVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AITIAGIPQSIIECVK 16 0 Q15366-3;Q15366-2;F8VZX2;F8VXH9;Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 79180400.0 6320400.0 58704000.0 14156000.0 False True 9588508.883133579 48227812.54355454 11358060.395204779 1.0 5.029751041727503 1.1845491862852506 23.192875047323636 -6.63518131928032 2.0616724651087615 3.6447726735878403 1.2002990688796191 0.13644188912739108 1.7262948369301503 0.5456426064480342 4.426343769428916 0.6832635883344637 1.911929030727382 2.3164273325262802e-07 6.63518131928032 -2.444473604708221 AITIAGIPQSIIECVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AITIAGIPQSIIECVK 16 0 Q15366-3;Q15366-2;F8VZX2;F8VXH9;Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 57266000.0 5389000.0 23544000.0 28333000.0 False True 7381458.9322491195 22503748.23040352 21641328.936451662 1.0 3.048685691670801 2.9318498057209377 22.8154745599056 -10.519183112115998 6.612729441231879 0.9986835712081794 2.9902677486958247 0.9974220781467632 0.047698050703862696 0.0009259649309669617 6.732747699024503e-05 0.04619532891668989 0.015394479668551403 3.025637455887385e-11 10.519183112115998 1.9915841774876453 AITIAGIPQSIIECVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AITIAGIPQSIIECVK 16 0 Q15366-3;Q15366-2;F8VZX2;F8VXH9;Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 32426000.0 17770000.0 0.0 14656000.0 False True 14776542.344477713 0.0 17720501.83831242 1.0 0.0 1.1992319600352868 23.816805387954307 -10.756751003561417 6.220813187401101 1.0122820304805158 0.5996159800176434 0.1293922717107514 0.4895843975540335 0.08337432973015456 0.0032601360692884086 0.4739132614460294 0.15801268485748018 1.7508502254834182e-11 10.756751003561417 -0.4126660504628724 AITIAGVPQSVTECVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AITIAGVPQSVTECVK 16 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 55510200.0 7840200.0 27530000.0 20140000.0 False True 10278578.124604808 23422631.311099514 18056105.996521622 1.0 2.278781269855851 1.7566735182270987 23.293137368971028 -10.469664521650595 7.266908328949329 0.9998575271343139 2.017727394041475 0.8351518541942372 0.2131495970403693 0.0004920693788994927 3.591117729061516e-05 0.2064089244006988 0.0687937366323477 3.391060033404094e-11 10.469664521650595 1.0178698669071609 AITIAGVPQSVTECVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AITIAGVPQSVTECVK 16 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 24213100.0 15210000.0 2966500.0 6036600.0 False True 14727166.875533052 4151038.9200931294 4455433.36588184 1.0 0.28186269329163705 0.3025316005133251 23.81197658421585 -10.697771433370622 10.439715306109859 1.000495144678482 0.29219714696073673 0.9993608626201677 0.008438046039010348 9.729868122211362e-05 2.816776244325898e-06 0.008174659446871436 0.0027233676486348767 2.005527246847505e-11 10.697771433370622 -0.7082979977177453 AITIAGVPQSVTECVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AITIAGVPQSVTECVK 16 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 71040200.0 7840200.0 25191000.0 38009000.0 False True 10738933.813438395 24077978.32450288 29032057.01992695 1.0 2.2421200039777123 2.703439421853691 23.35634743049392 -9.861416657018781 0.2541101813066738 4.639242465503656e-21 2.9584039264807385 0.9990693994530444 0.021944787792132166 1.2902201014219927 0.11139996543110342 1.15203253278711 0.20139912820606765 1.3758888239319294e-10 9.861416657018781 2.9584039264807385 AITIANQTNCPLYITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AITIANQTNCPLYITK 16 0 A0A1C7CYX9;Q16555-2;Q16555 A0A1C7CYX9 DPYSL2 Dihydropyrimidinase-related protein 2 0 11471700.0 1682600.0 4141700.0 5647400.0 False True 2205904.894321577 3523774.5042201555 5063061.221686009 1.0 1.597428118179994 2.295230966085302 21.07293916104749 -6.969080896276824 0.2792663175992218 0.8449064559006767 3.068994905413989 0.9999743000219327 0.002683312340799986 0.07660207400744899 0.01009311240542268 0.012943975206586772 0.06410907246653516 1.0737893783615979e-07 6.969080896276824 2.2240884495133124 AITIANQTNCPLYITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AITIANQTNCPLYITK 16 0 A0A1C7CYX9;Q16555-2;Q16555 A0A1C7CYX9 DPYSL2 Dihydropyrimidinase-related protein 2 0 7564000.0 1682600.0 3096300.0 2785100.0 False True 2304702.6905552694 2959495.227905137 2127316.740935002 1.0 1.2841114995149805 0.9230330444151432 21.13614922257038 -6.69696641448025 1.84250672665922 1.176951720595797 0.924194531523762 0.40286601821179147 0.11999562876042276 0.4018416335452128 2.6501926745626014 0.05200856377220605 0.13421474178760592 2.009248188829959e-07 6.69696641448025 -0.2527571890720349 AITTGLQEYVEAVSFQHFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AITTGLQEYVEAVSFQHFIK 20 0 Q99598;C4P0D6;C4P0D8;Q5VVQ1 Q99598 TSNAX;DISC1 Translin-associated protein X 0 16221900.0 5218200.0 3140100.0 7863600.0 False True 5052551.097298265 4393958.30540518 5803887.257056684 1.0 0.8696514336598689 1.1487043169459836 22.268580576220337 -6.77970268062273 1.53718961268853 0.9261644347570154 1.150887922102336 0.7662797425916993 0.055115281123418416 0.25103876500713074 1.171677434632072 0.028241356123821372 0.06664985250067311 1.660723454886179e-07 6.77970268062273 0.22472348734532066 AITTGLQEYVEAVSFQHFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AITTGLQEYVEAVSFQHFIK 20 0 Q99598;C4P0D6;C4P0D8;Q5VVQ1 Q99598 TSNAX;DISC1 Translin-associated protein X 0 12428300.0 5218200.0 2819600.0 4390500.0 False True 4339164.505456027 2804410.2551532225 5308533.250621632 1.0 0.6463018978946251 1.2233998604908225 22.048985851654614 -6.740849103800516 1.6834942279795857 0.7897598089117305 1.2238076265559792 0.6087903551108969 0.14860641700804447 0.31628117006449646 1.7603721410284467 0.06982185505024611 0.17118330143258062 1.816146575721517e-07 6.740849103800516 0.4340478176442487 AITVFSPDGHLFQVEYAQEAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AITVFSPDGHLFQVEYAQEAVK 22 0 O14818;Q8TAA3-5;Q8TAA3;O14818-4;Q8TAA3-2;F5GY34 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 0 20220300.0 7959900.0 9227700.0 3032700.0 False True 10435505.983781243 7850963.129292876 2718905.295712568 1.0 0.7523318123236922 0.26054369571904445 23.314997218000563 -7.0084740660699465 0.4456759042014839 1.0168954376568498 2.4436738627864864e-12 0.999767613647218 0.004684797407896662 0.07436848041177696 0.021478472877981106 0.006439659645812926 0.0379412555096305 9.806768737722139e-08 7.0084740660699465 -1.0168954376544062 down AITVFSPDGHLFQVEYAQEAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AITVFSPDGHLFQVEYAQEAVK 22 0 O14818;Q8TAA3-5;Q8TAA3;O14818-4;Q8TAA3-2;F5GY34 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 0 121398000.0 55742000.0 24619000.0 41037000.0 False True 53972500.72162817 34449495.08638894 30288178.616388854 1.0 0.6382786534955595 0.5611779741799439 25.685721197827633 -13.999999999999998 0.21724949189093565 3.156832438476413 0.5188337843782983 0.9994952903703668 0.004297630265569252 12.926327181490125 0.1476801391131271 11.943612152906033 0.04345721421606788 1.0000000000000041e-14 13.999999999999998 -2.637998654098115 AITVFSPDGHLFQVEYAQEAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AITVFSPDGHLFQVEYAQEAVK 22 0 O14818;Q8TAA3-5;Q8TAA3;O14818-4;Q8TAA3-2;F5GY34 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 0 141839000.0 37197000.0 63155000.0 41487000.0 False True 56430568.4649579 51884496.817732796 33287076.265601974 1.0 0.919439556061745 0.589876678032625 25.749973547152738 -6.944359608066342 0.6176837266284619 1.003613437909127 0.4883126603885135 0.9986808703613368 0.0064438846141008435 0.08583307479512095 0.045968713482566925 0.00650326433281555 0.027866803606296803 1.1366856882689838e-07 6.944359608066342 -0.5153007775206135 AITVFSPDGHLFQVEYAQEAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AITVFSPDGHLFQVEYAQEAVK 22 0 O14818;Q8TAA3-5;Q8TAA3;O14818-4;Q8TAA3-2;F5GY34 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 0 37459800.0 7959900.0 8626900.0 20873000.0 False True 10902890.13820925 8245735.032656657 15943227.292928915 1.0 0.7562889223068867 1.462293675422425 23.378207279523455 -6.813501472675281 1.3998216141284903 0.8677200005936644 1.4756527047079944 0.8687634491525353 0.1060691525820371 0.2020621325320864 0.7796812315104729 0.05957055408215166 0.1375897441198656 1.5363795835208245e-07 6.813501472675281 0.60793270411433 AITVFSPDGHLFQVEYAQEAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AITVFSPDGHLFQVEYAQEAVK 22 0 O14818;Q8TAA3-5;Q8TAA3;O14818-4;Q8TAA3-2;F5GY34 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 0 96848000.0 55742000.0 19155000.0 21951000.0 False True 46351942.78930091 19051808.213030174 26540852.610043377 1.0 0.41102502002198205 0.5725941786450774 25.46612647326191 -10.63725088451905 10.023916695282384 1.0001174517636264 0.4918095993337118 0.9295323501268167 0.06596033279956341 0.00017317261788964006 6.266828699975342e-06 0.06388010893448504 0.021288605870250655 2.3054150050177738e-11 10.63725088451905 -0.5083078524299146 AITVFSPDGHLFQVEYAQEAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AITVFSPDGHLFQVEYAQEAVK 22 0 O14818;Q8TAA3-5;Q8TAA3;O14818-4;Q8TAA3-2;F5GY34 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 0 90475000.0 37197000.0 32538000.0 20740000.0 False True 48152249.76248824 30727231.69679924 16965532.810370814 1.0 0.6381266056801461 0.35233105190419106 25.521099869245187 -7.687845545087426 0.2181803226730624 1.1889552561406538 6.601334983203487e-13 0.9998767627773912 0.002942008984005816 0.13058972726681622 0.02742689941871408 0.04419523374740474 0.08054748410569364 2.0518917953215035e-08 7.687845545087426 -1.1889552561399936 down AITVFSPDGHLFQVEYAQEAVKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AITVFSPDGHLFQVEYAQEAVKK 23 1 O14818;Q8TAA3-5;Q8TAA3;O14818-4;Q8TAA3-2;F5GY34 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 0 117709000.0 21226000.0 57745000.0 38738000.0 False True 32201393.82845915 47439953.586255714 31081417.320531476 1.0 1.4732267130725545 0.9652196263958657 24.940619800560288 -6.662151036605251 1.965551816274392 1.3040792415119986 0.9673435006928329 0.24462741092333795 0.20138808951625758 0.479390436321265 3.5626635562324536 0.08271926687995082 0.2232633415066428 2.1769525518089965e-07 6.662151036605251 -0.3367357408191657 AITVFSPDGHLFQVEYAQEAVKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AITVFSPDGHLFQVEYAQEAVKK 23 1 O14818;Q8TAA3-5;Q8TAA3;O14818-4;Q8TAA3-2;F5GY34 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 0 70380600.0 21226000.0 31165600.0 17989000.0 False True 27477475.42701224 29431206.963235803 14715186.582727127 1.0 1.0711030218701574 0.5355363385480855 24.711746122652738 -6.873448147025702 1.11563604412807 1.0411911850772242 0.5020368382864717 0.9680078360181853 0.04247831314997722 0.13359458427883444 0.3086753106549739 0.02948220999572815 0.07025271966433476 1.338294992531339e-07 6.873448147025702 -0.5391543467907525 AIVAIENPADVSVISSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIVAIENPADVSVISSR 17 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 113392000.0 29525000.0 43420000.0 40447000.0 False True 38707560.92050673 36941905.24983442 36261932.435020395 1.0 0.9543847344373256 0.9368178095615765 25.20611206616484 -13.99999999995074 0.13212722545085856 1.2168739174468717 0.9128684617049126 0.999636048032015 0.000507958967196316 11.933963332646053 0.11324201313235982 0.6709160461561571 0.021317052981263008 1.0000000001134257e-14 13.99999999995074 -0.30400545574195903 AIVAIENPADVSVISSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIVAIENPADVSVISSR 17 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 106307000.0 35892000.0 23853000.0 46562000.0 False True 34752628.106287494 33377627.29175173 34366015.36994169 1.0 0.9604346235245732 0.9888752949801843 25.0506187474445 -10.011471438608798 4.4199606595479395 1.000001081836977 0.97465495924841 0.5142979886902409 0.011610855514708689 2613596.964661229 5919950.892903462 14.207434629820806 0.003974704603016866 9.739318338823296e-11 10.011471438608798 -0.025346122588566944 AIVAIENPADVSVISSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIVAIENPADVSVISSR 17 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 231066000.0 19453000.0 183140000.0 28473000.0 False True 29511623.204796758 150457236.12064907 22845299.06984076 1.0 5.098236551630751 0.7741119121542435 24.81477993859405 -6.65830675740051 1.97894294125638 3.641660835610208 0.7922038941195275 0.22841997271246328 1.7456460292637983 0.4884663091140462 3.6755567855141775 0.7131251591668439 1.9347393448636083 2.196307995530088e-07 6.65830675740051 -2.8494569414906805 AIVAIENPADVSVISSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIVAIENPADVSVISSR 17 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 122135000.0 29525000.0 41912000.0 50698000.0 False True 40441190.383123964 40060189.2555502 38724176.55808512 1.0 0.9905788844501284 0.957542945477803 25.269322127687733 -6.947904509651426 0.581432228850567 1.0003928165034242 0.9460910884711153 0.9990259949287873 0.0005681252349009099 0.08433912941652988 0.03953616513093433 0.000594326829237101 0.0027607448953970784 1.1274453255743198e-07 6.947904509651426 -0.054301728032308816 AIVAIENPADVSVISSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIVAIENPADVSVISSR 17 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 70201000.0 35892000.0 17251000.0 17058000.0 False True 29845788.28519945 17158065.4389446 20624748.932719246 1.0 0.574890677203299 0.691043866412035 24.831024022878776 -10.262885483998563 8.177269907254633 1.0000003444454426 0.6329672718076709 0.9301349570885757 0.04741934092639208 2.9778893099939104e-07 2.6773412171326813e-08 0.04591362252452877 0.0153045264746707 5.459017870474136e-11 10.262885483998563 -0.36703307263777174 AIVAIENPADVSVISSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIVAIENPADVSVISSR 17 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 73438000.0 19453000.0 32045000.0 21940000.0 False True 25182291.97595728 30261667.58018109 17947145.123410594 1.0 1.2017042614339206 0.7126891047306408 24.5859062606865 -6.794690164853163 1.477423462079546 1.1120503818576588 0.7067866394114843 0.8161875108048384 0.0860282645637153 0.2284354778484194 0.9848516877307043 0.04581993827686983 0.10692653685231414 1.6043895889865736e-07 6.794690164853163 -0.40526374244617447 AIVEFLSNLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIVEFLSNLAR 11 0 Q13112 Q13112 CHAF1B Chromatin assembly factor 1 subunit B 0 6898600.0 2099500.0 1602200.0 3196900.0 False True 2032852.521708197 2241966.8153626216 2359535.9850557633 1.0 1.1028674197568975 1.1607019987229845 20.955074124439008 -13.999999999991875 0.06734379585985976 0.39102858208755514 1.382580953885338 0.9999331336422906 0.0005434202253177811 12.388419963858047 0.06913527190543058 1.2055019775773534 0.20526670978362743 1.0000000000187086e-14 13.999999999991875 0.9915523717977828 AIVEK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIVEKLR 7 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 13400100.0 3571100.0 5614900.0 4214100.0 True False 4681746.682581596 4777178.8067087745 3778065.356501579 1.0 1.0203838717891835 0.8069777398588956 22.158615445322546 -6.883479865673164 1.0602298483888712 1.013322094582179 0.7908089534992181 0.9763845357994626 0.014776734681617651 0.12459097284770572 0.25405293831586634 0.010700583619369711 0.026120755381886816 1.307736165472309e-07 6.883479865673164 -0.22251314108296094 AIVEK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIVEKLR 7 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 28147200.0 5925100.0 7879100.0 14343000.0 True False 5737010.943735769 11025265.718963709 10586138.01922327 1.0 1.9217787497864502 1.8452358071204749 22.45186783935489 -10.557800172979826 6.003893710887718 0.9980443579302616 1.8835072784534626 0.9944022509788207 0.031248525490458114 0.0008192095689921193 6.033646092653652e-05 0.030300966869761095 0.010085418234840162 2.768215059992183e-11 10.557800172979826 0.885462920523201 AIVEK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIVEKLR 7 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 13687400.0 3571100.0 4480300.0 5636000.0 True False 4891432.175348824 4282345.531629162 4304892.877063549 1.0 0.8754788736948548 0.8800884327413889 22.221825506845438 -10.660044420580968 6.537682300007423 1.0007321629082984 0.8777836532181218 0.9989342326371003 0.0018818446005398014 2.0200358518709898e-05 1.0504063698332444e-06 0.0018327841759772131 0.0006073627331700863 2.1875378663919497e-11 10.660044420580968 -0.12294850969017657 AIVEK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIVEKLR 7 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 27599300.0 5925100.0 16457000.0 5217200.0 True False 4926983.176435847 16368342.874541266 6308092.398392715 1.0 3.322183634160902 1.280315392299747 22.232273114789166 -6.615089190306919 2.134438551227 2.5460571927795717 1.287815523528929 0.06668241912945416 0.9998610075702339 0.5986973054723739 5.175686257177018 0.3858004443612596 1.1095299912865344 2.4261117975314354e-07 6.615089190306919 -1.2582416692506426 AIVESVESCEISLRPLLVSHVMACGGNTLYPGFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIVESVESCEISLRPLLVSHVMACGGNTLYPGFTK 35 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 62535000.0 12106000.0 34319000.0 16110000.0 False True 18365687.067150008 28194506.31442913 12925851.438736156 1.0 1.535172967466028 0.7038044039123439 24.13050953304608 -6.732889713858309 1.7128335189299877 1.321021312970391 0.704042008720029 0.5725896388681936 0.22492639183775137 0.33082626626351636 1.9027517328551804 0.10401322050166792 0.2572478881876216 1.849738287848684e-07 6.732889713858309 -0.616979304250362 AIVESVESCEISLRPLLVSHVMACGGNTLYPGFTK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 2 AIVESVESCEISLRPLLVSHVMACGGNTLYPGFTKR 36 2 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 736789600.0 323669600.0 120575000.0 292545000.0 True False 491030446.61734825 99057449.19322501 234723352.5229714 1.0 0.20173382297497086 0.4780219926074917 28.871237241524874 -10.362753099017848 5.8064758747248435 1.0001316635348296 0.33987790780711546 0.8838744253637323 0.11279417292787156 0.00019228796253848294 2.1102885304991868e-05 0.10923392931516317 0.03640416277490641 4.3375740395238696e-11 10.362753099017848 -0.6602537557277142 AIVESVESCEISLRPLLVSHVMACGGNTLYPGFTK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AIVESVESCEISLRPLLVSHVMACGGNTLYPGFTKR 36 2 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 705614600.0 323669600.0 138867000.0 243078000.0 True False 418996677.681658 131138929.37609635 198840298.19090265 1.0 0.3129832200620265 0.47456294711237773 28.642363563617323 -10.372056336834579 8.828530938877748 1.0000017330662216 0.3937730835917455 0.9494151203738433 0.06596464734192349 2.2502367355861134e-06 1.5997972267131144e-07 0.06387017780250691 0.021289998382809587 4.245644857179919e-11 10.372056336834579 -0.6062286494744762 AIVFVVDSAAFQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIVFVVDSAAFQR 13 0 Q9Y5M8;H7C4H2 Q9Y5M8 SRPRB Signal recognition particle receptor subunit beta 0 2967710.0 944980.0 1149200.0 873530.0 False True 1238877.9311993362 977743.8395465144 783145.4950914369 1.0 0.7892172545199652 0.6321409683464838 20.240602612549907 -6.974358984201223 0.11294577638140393 1.3151420694882432 0.10219955706765146 0.9999995721126734 9.841512801070479e-05 0.07491185079554503 0.0033454576743812093 0.012031113793683582 0.02360622548024018 1.0608183310985301e-07 6.974358984201223 -1.2129425124205917 AIVHAVGQELQVTGPFNLQLIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIVHAVGQELQVTGPFNLQLIAK 23 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 104658000.0 32721000.0 38400000.0 33537000.0 False True 49640149.225525826 31547219.979430567 26908397.250210714 1.0 0.635518234163737 0.5420692256173547 25.565004116637954 -13.999999999999998 0.19110360805517174 2.9613482438812775 0.47576735123348374 0.9994888382124811 0.004466675999381141 12.368884052534101 0.13863126716664884 9.037024223217523 0.06370654417688677 1.0000000000000041e-14 13.999999999999998 -2.4855808926477936 AIVHAVGQELQVTGPFNLQLIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIVHAVGQELQVTGPFNLQLIAK 23 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 61517000.0 32721000.0 15279000.0 13517000.0 False True 42357979.52733755 14428710.218679553 11057044.696132226 1.0 0.3406373575814059 0.26103805751631953 25.336130438730404 -13.999999999999998 0.29825292872362547 6.9545035875963706 0.2410958892801653 0.9996459304381503 0.006231844489617613 16.475497926921584 0.17339139619320537 60.48077126228035 0.028984465615374058 1.0000000000000041e-14 13.999999999999998 -6.713407698316205 AIVQQWLEYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIVQQWLEYR 10 0 O43324;D6RBD7;C9J1V9;O43324-2;H0YAL7;D6RCQ0 O43324 EEF1E1;EEF1E1-BLOC1S5 Eukaryotic translation elongation factor 1 epsilon-1 0 12533200.0 4563900.0 5370200.0 2599100.0 False True 5983317.09687047 4568987.092875645 2330170.0643276754 1.0 0.7636210849104788 0.3894445215926219 22.512514092614545 -6.964347245386321 0.3690838732690886 1.0290749627611735 0.11098484680474949 0.9998990502934146 0.0025255553763626768 0.07818317651529985 0.01564525464265746 0.004938903526371077 0.03179429687161068 1.0855573061012325e-07 6.964347245386321 -0.918090115956424 down AIVQQWLEYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIVQQWLEYR 10 0 O43324;D6RBD7;C9J1V9;O43324-2;H0YAL7;D6RCQ0 O43324 EEF1E1;EEF1E1-BLOC1S5 Eukaryotic translation elongation factor 1 epsilon-1 0 11313900.0 3978000.0 1891500.0 5444400.0 False True 3851720.56744711 2646785.8140421943 4018348.31150102 1.0 0.6871697382233684 1.0432606003307112 21.877071612437735 -6.674621480326896 1.9205025006771903 0.8011314830108295 1.0418719256455504 0.29996218989511503 0.13274161753437708 0.4505474355130046 3.2078340682422612 0.05555166842762838 0.14755778304131725 2.1153319043983657e-07 6.674621480326896 0.24074044263472094 AIVQQWLEYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIVQQWLEYR 10 0 O43324;D6RBD7;C9J1V9;O43324-2;H0YAL7;D6RCQ0 O43324 EEF1E1;EEF1E1-BLOC1S5 Eukaryotic translation elongation factor 1 epsilon-1 0 14228600.0 2137600.0 12091000.0 0.0 False True 3242895.4794928054 9933266.582585827 0.0 1.0 3.06308564226048 0.0 21.628851094922574 -6.725353451153276 1.7404393739439872 2.2481027644195737 0.003547925992805911 0.5371563005626263 0.8676586477740045 0.3451960006474257 2.0463157941055803 0.3954355271510355 0.9863504754178962 1.8821167027749814e-07 6.725353451153276 -2.244554838426768 AIVQQWLEYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIVQQWLEYR 10 0 O43324;D6RBD7;C9J1V9;O43324-2;H0YAL7;D6RCQ0 O43324 EEF1E1;EEF1E1-BLOC1S5 Eukaryotic translation elongation factor 1 epsilon-1 0 14777200.0 4563900.0 4210800.0 6002500.0 False True 6251297.164760015 4024752.932746484 4584833.125367979 1.0 0.6438268453201893 0.7334210811819548 22.575724154137436 -9.852757545372034 6.239647424170762 1.0000000216220448 0.6886239632509756 0.9415360703369126 0.03657669362633158 1.1033662194012736e-08 2.029838327213464e-09 0.03541523395701106 0.011805077106124698 1.4035970753993223e-10 9.852757545372034 -0.3113760583710692 AIVQQWLEYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIVQQWLEYR 10 0 O43324;D6RBD7;C9J1V9;O43324-2;H0YAL7;D6RCQ0 O43324 EEF1E1;EEF1E1-BLOC1S5 Eukaryotic translation elongation factor 1 epsilon-1 0 8547300.0 3978000.0 2135500.0 2433800.0 False True 3307883.2552803806 2123995.637636439 2942696.3273802362 1.0 0.642101148595828 0.8896010228543599 21.65747688787201 -10.119928369557844 5.323378345004614 1.000004836574578 0.7658510857249524 0.544079399549362 0.10104140055656244 5.800101036033683e-06 9.590734215395955e-07 0.09783493563317384 0.03261097180268169 7.587027014829657e-11 10.119928369557844 -0.23415375084962553 AIVQQWLEYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIVQQWLEYR 10 0 O43324;D6RBD7;C9J1V9;O43324-2;H0YAL7;D6RCQ0 O43324 EEF1E1;EEF1E1-BLOC1S5 Eukaryotic translation elongation factor 1 epsilon-1 0 16852200.0 2137600.0 9020300.0 5694300.0 False True 2767165.3383954284 8518312.375519034 4657995.828452007 1.0 3.078353236550177 1.6833095456280172 21.399977417015023 -10.479265295461465 6.177149362943381 0.9991615386141178 2.3808313910890684 0.5664059092462771 0.5695242019413699 0.006579427635770901 0.0005546450250932003 0.5516952699512964 0.1838131457817495 3.316917766320817e-11 10.479265295461465 1.3816698524749507 AIVWGMQTR ddPTM_RPMI8226_Bortezomib_1h_R1 2 AIVWGMQTR 9 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 81848700.0 29309600.0 22191000.0 30348100.0 False True 38425169.43457015 18880189.299840484 27207969.73153118 1.0 0.49134953931665576 0.7080767666583888 25.195548285659793 -10.276113927907707 5.653168759800671 1.0000323683969548 0.5997131529875167 0.8197664232218589 0.08847852005925767 3.609832360918272e-05 4.622490131143471e-06 0.08567587023206125 0.028556319557212103 5.295245161911036e-11 10.276113927907707 -0.40031921540943805 AIVWGMQTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIVWGMQTR 9 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 36038400.0 13510000.0 4857400.0 17671000.0 False True 13081132.4450001 6796985.15100637 13042434.981363341 1.0 0.5196021964905897 0.9970417344370249 23.640984105817036 -10.91189070637627 10.984089365061715 1.026027761893777 0.7583219654673977 0.2546469013654664 0.19491387516648884 0.09605828121707301 0.000770533853801558 0.1459209058856754 0.06290818270538026 1.2249244223495627e-11 10.91189070637627 -0.26770579642637926 AIVWGMQTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIVWGMQTR 9 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 29189300.0 7590300.0 11016000.0 10583000.0 False True 11515040.025259266 9050108.73159916 8491265.411306318 1.0 0.7859381045786155 0.7374065042483544 23.457016090031196 -13.999999999999998 0.20852048859692673 2.2305299712393234 0.7084080519977072 0.9994892321674793 0.002578275651343739 12.712494809794721 0.14474635526481994 6.404394789760555 0.029048675810098838 1.0000000000000041e-14 13.999999999999998 -1.5221219192416162 AIVWGMQTR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AIVWGMQTR 9 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 75042400.0 29309600.0 26058900.0 19673900.0 False True 40146151.18215782 24907531.63274135 15027330.016689222 1.0 0.6204214077640154 0.3743155837904538 25.258758347182685 -8.43167158558906 0.17088119639400082 1.3635729180925675 1.824692991791943e-06 0.9998491879005764 0.0031605759317872126 0.12750091745105271 0.04083228217112701 0.14891918200041662 0.1340426588274462 3.701079504046628e-09 8.43167158558906 -1.3635710933995757 down AIVWGMQTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIVWGMQTR 9 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 29608000.0 13510000.0 9067000.0 7031000.0 False True 11234163.594479108 9018154.271341411 8501149.592329068 1.0 0.8027437196813898 0.7567229656960713 23.421389381251313 -13.999999999999998 0.2044686547717092 2.1156665142371343 0.7281173529504367 0.9994876614753966 0.0023884443315259586 12.622902869308021 0.14335850757337548 5.643069875439955 0.028356645932800108 1.0000000000000041e-14 13.999999999999998 -1.3875491612866977 AIVWGMQTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIVWGMQTR 9 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 35636300.0 7590300.0 17527000.0 10519000.0 False True 9825792.977181321 16551607.04252876 8604649.934054518 1.0 1.6845059814477021 0.8757206623462663 23.228142412123645 -6.682423768302057 1.8934278638056894 1.432158379563726 0.8787520906185513 0.33514826497861583 0.2899590072260835 0.4331822331780026 3.0046426646183235 0.12279150621303264 0.32283420492682824 2.0776683866394276e-07 6.682423768302057 -0.5534062889451747 AIWAALQTQTSNAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIWAALQTQTSNAAK 15 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 13197100.0 3206600.0 3886800.0 6103700.0 False True 4203883.652758573 3306904.5906277355 5472147.674824686 1.0 0.7866308546521635 1.301688659065025 22.003291310957525 -6.794180298177872 1.4794257532369326 0.8813949925532251 1.3078290405623674 0.8146504182932323 0.09096914166509507 0.2291638045147733 0.9906926273520674 0.048387091821469386 0.11295903075597208 1.6062742667637488e-07 6.794180298177872 0.4264340480091423 AIWAALQTQTSNAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIWAALQTQTSNAAK 15 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 9486100.0 3112200.0 1339400.0 5034500.0 False True 3013404.914532148 1874229.4048787274 3715813.418237434 1.0 0.6219640101601529 1.2330946300372447 21.52296311180122 -6.739397303894395 1.6891202025347514 0.7749114995806731 1.233391040209666 0.6021533255667256 0.15883640202649665 0.318901519659866 1.786337433606041 0.07440159060710777 0.18268041742755692 1.8222279180475005e-07 6.739397303894395 0.4584795406289929 AIWAALQTQTSNAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIWAALQTQTSNAAK 15 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 10412700.0 3206600.0 2840800.0 4365300.0 False True 4392166.6751067 2715284.062730652 3334306.0461755674 1.0 0.6182106153029107 0.7591483413125634 22.066501372480417 -10.243305767541766 4.710568672531583 1.000084868710466 0.6886794783067332 0.8667694330228046 0.05753758570874858 5.129697275281851e-05 8.240320141503665e-06 0.05572566675012169 0.018570175935425988 5.7107642543870535e-11 10.243305767541766 -0.31140539040373283 AIWVTGWGHTQYGGTGALILQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIWVTGWGHTQYGGTGALILQK 22 0 Q9Y5Y6 Q9Y5Y6 ST14 Suppressor of tumorigenicity 14 protein 0 21384100.0 10402000.0 6957200.0 4024900.0 False True 13465594.054074297 6570025.704129685 3292409.498961496 1.0 0.4879120577782297 0.24450532859820684 23.682774542024532 -9.871652025520312 0.18835451594952804 1.6123310690483181 1.858571438830084e-22 0.9995185606445036 0.006908653632225376 1.3564773884566486 0.08327642777427596 0.5859403182098485 0.1541273640321023 1.3438412704101316e-10 9.871652025520312 -1.6123310690483181 AIYAYALQVFPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIYAYALQVFPSK 13 0 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 0 5819000.0 1825900.0 2844100.0 1149000.0 False True 2393772.582040755 2419771.366214968 1030112.5019862641 1.0 1.0108610084221317 0.43033014485781507 21.190854666322934 -6.902637849952677 0.9444403560529544 1.022420666975126 0.3660210172830117 0.9878336035999598 0.02990724669658268 0.1094896046135902 0.16667116078027597 0.023627079141982744 0.06232856489215662 1.2513020326533427e-07 6.902637849952677 -0.6563996496921143 down AIYAYALQVFPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIYAYALQVFPSK 13 0 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 0 6632200.0 1825900.0 1811100.0 2995200.0 False True 2500984.5730921626 1731079.6134931985 2287795.4480803297 1.0 0.6921592528469416 0.9147579208182598 21.254064727845826 -10.456541599413544 5.07353476137703 1.000343715397403 0.8034585868325927 0.5096706650772208 0.09087552565885137 0.00035392408779698803 3.791105950233752e-05 0.08814230498278444 0.02932994978787738 3.495090298570096e-11 10.456541599413544 -0.19688512856481033 AIYAYALQVFPSKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIYAYALQVFPSKK 14 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 0 8429000.0 3042400.0 3165900.0 2220700.0 False True 3988615.8626435087 2693560.060581545 1990923.2664585682 1.0 0.6753119762193274 0.4991514186926632 21.927456755736188 -12.477786810086483 0.0872642676179599 2.3452654898488547 2.33986313850234e-16 0.9998945869166329 0.002129857202798928 6.983731233621491 0.06982131687302004 2.0916518885563677 0.38987649343826053 3.3282289193634097e-13 12.477786810086483 -2.3452654898488543 AIYAYALQVFPSKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AIYAYALQVFPSKK 14 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 0 17852600.0 3816900.0 4640000.0 9395700.0 False True 5790516.352767625 3811955.747514535 7538635.776718393 1.0 0.6583101601453175 1.3018935302920334 22.465260571487267 -6.762475406225893 1.6032736355117265 0.8021399661554465 1.304527569308502 0.7009615286750531 0.14377034257779261 0.2787700202824304 1.4128493225557848 0.0707362734537774 0.16956927493927879 1.7279238287809803e-07 6.762475406225893 0.5023876031530556 AIYAYALQVFPSKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIYAYALQVFPSKK 14 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 0 10384200.0 3042400.0 2605200.0 4736600.0 False True 4167257.4977685446 2490093.6497556637 3617912.633339107 1.0 0.5975377454090712 0.8681759251201546 21.99066681725908 -10.763885160522666 5.369244888966366 1.0144206777319755 0.7328568352646129 0.565050677367849 0.11048757420130172 0.019484748702010203 0.0008568495954363414 0.10928985574538436 0.035659711237041467 1.7223239448824687e-11 10.763885160522666 -0.28156384246736266 AIYAYALQVFPSKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AIYAYALQVFPSKK 14 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 0 3999200.0 1224000.0 1047900.0 1727300.0 False True 1017810.2323939643 1042254.7547081367 2088470.4438671547 1.0 1.0240167779180969 2.0519251795640914 19.95703716973092 -6.911934028919746 0.8824784032669315 0.9700859077426826 2.1904021901852695 0.9916304892572412 0.04485689555960257 0.10315348046803802 0.13194032987115703 0.03707948433210241 0.10377870052297199 1.224802237525597e-07 6.911934028919746 1.220316282442587 up AIYAYALQVFPSKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AIYAYALQVFPSKK 14 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 0 21992000.0 3816900.0 9530700.0 8644400.0 False True 4941052.292347259 9000308.166841384 7071207.899034206 1.0 1.8215367161325398 1.4311137548546387 22.236386893579716 -10.525061407397045 7.201148841442895 0.9997619345265287 1.626325235493589 0.7743362758859499 0.1593895064995421 0.0006094221561921227 4.019314154757761e-05 0.1543844704475345 0.05144274201941214 2.98496052832413e-11 10.525061407397045 0.6265633009670604 AIYFDGDFGQIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIYFDGDFGQIVR 13 0 Q96RP9;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 4370500.0 1256500.0 1871900.0 1242100.0 False True 1647283.6679633083 1592619.8166090518 1113579.407064525 1.0 0.9668157631758454 0.6760094989840747 20.651657582873614 -6.928441028003704 0.7594798708563717 1.00468755759371 0.6186114993077424 0.9962228602755901 0.00894471324825107 0.09345551419870946 0.08170549798830545 0.00807472996724799 0.026542119528682045 1.1791226231231287e-07 6.928441028003704 -0.3860760582859676 AIYFDGDFGQIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIYFDGDFGQIVR 13 0 Q96RP9;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 7540100.0 2698800.0 1915200.0 2926100.0 False True 2613128.0712484317 2679949.3476360585 2159666.628881631 1.0 1.0255713744469106 0.8264679610019429 21.317346403215602 -6.874631966046262 1.1092567851875523 1.0149595672599003 0.813730898304012 0.9690934792879354 0.015549599167638208 0.1324934509753898 0.30190054169745717 0.010845250074555411 0.02590503907972195 1.3346519765186047e-07 6.874631966046262 -0.2012286689558883 AIYFDGDFGQIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIYFDGDFGQIVR 13 0 Q96RP9;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 4936100.0 1256500.0 1369500.0 2310100.0 False True 1721062.0056357405 1308990.961669117 1764501.9580029259 1.0 0.7605716455204592 1.0252402018201192 20.714867644396506 -6.668413685722139 1.942579409851135 0.8469724551008405 1.0241739961984406 0.2722640793815868 0.1017400050458961 0.4647398570607699 3.379400454485504 0.042182600466302504 0.11295211119413344 2.1457855396667484e-07 6.668413685722139 0.1772015410976001 AIYHLEAFVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIYHLEAFVAK 11 0 P40938 P40938 RFC3 Replication factor C subunit 3 0 6524500.0 1472800.0 2241400.0 2810300.0 False True 1930855.0626154884 1906991.8569087698 2519517.1143011325 1.0 0.9876411201603117 1.3048711749955262 20.880808443455503 -6.897832750283623 0.9748503545655091 0.9860150352769592 1.3367442019239526 0.985457389059235 0.01769305921225385 0.11301879998909777 0.18654573812681252 0.01366558899696198 0.0351848838631781 1.2652234997137992e-07 6.897832750283623 0.3507291666469934 AIYHLEAFVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AIYHLEAFVAK 11 0 P40938 P40938 RFC3 Replication factor C subunit 3 0 4015370.0 1609600.0 420070.0 1985700.0 False True 1558504.129050493 587806.1416361112 1465585.6002769042 1.0 0.37716046475553944 0.9403796710951297 20.571730546522154 -10.56401331750249 9.246607499837067 1.0000317431039638 0.6587700679253397 0.3285958552386865 0.22993327814455142 0.00015047899622121176 7.09542340164428e-06 0.2226525463725441 0.07421064641606043 2.7288941008532613e-11 10.56401331750249 -0.34126167517862416 AIYHLEAFVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIYHLEAFVAK 11 0 P40938 P40938 RFC3 Replication factor C subunit 3 0 5294300.0 1472800.0 1888400.0 1933100.0 False True 2017333.9609234533 1804964.2438962825 1476541.593444205 1.0 0.894727535876134 0.7319271979976505 20.944018504978395 -6.964745517600156 0.3623979528740841 1.0136497664153268 0.6074051795395374 0.9999077946655756 0.0010589043849462444 0.07804747600986403 0.015165408958600555 0.002173935126826323 0.01388550906366214 1.0845622459591764e-07 6.964745517600156 -0.40624458687578935 AIYQATYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AIYQATYR 8 0 P28074;P28074-3 P28074 PSMB5 Proteasome subunit beta type-5 0 9947800.0 2640900.0 3887200.0 3419700.0 False True 3462245.474511976 3307244.912186925 3065862.2480787034 1.0 0.9552312037184771 0.8855126739708873 21.723276585278377 -6.9646267532852235 0.3644025805296444 1.0057134422053173 0.8326248271172828 0.9999052269704962 0.00045856445260874433 0.078087846453416 0.015308014165087692 0.0009275257147359957 0.005939534922771727 1.0848588762670807e-07 6.9646267532852235 -0.17308861508803453 AIYQATYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AIYQATYR 8 0 P28074;P28074-3 P28074 PSMB5 Proteasome subunit beta type-5 0 9618900.0 2640900.0 3584800.0 3393200.0 False True 3617312.097639016 3426411.682651657 2591796.0451476295 1.0 0.9472258931951275 0.7164977682847077 21.78648664680127 -6.942837497691028 0.6326169390058177 1.0025175871028589 0.648715220722804 0.9985124154780848 0.004748069042145667 0.08649572671520447 0.048891807255662834 0.004728074181533003 0.019623592236860343 1.1406765208064957e-07 6.942837497691028 -0.3538023663800549 AK(ub)AAAMAAAAAETSQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKAAAMAAAAAETSQR 16 1 A0A3B3IRK3;H7C5F7;B4DGY6;A0A0C4DGW0;Q9NV92 A0A3B3IRK3 NDFIP2 NEDD4 family-interacting protein 2 1 15431200.0 4446300.0 5185900.0 5799000.0 True False 5829142.358030447 4412183.934479876 5198975.107935895 1.0 0.7569181988498677 0.8918936592402124 22.47485220457927 -10.112170662178114 4.8202173860975615 1.0000092252721728 0.8244059291365022 0.6929284403523841 0.055103500963655364 5.4632253256188795e-06 1.006304414445793e-06 0.053356537824161936 0.017784578461824928 7.723770089487497e-11 10.112170662178114 -0.1756032961356706 AK(ub)AAAMAAAAAETSQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKAAAMAAAAAETSQR 16 1 A0A3B3IRK3;H7C5F7;B4DGY6;A0A0C4DGW0;Q9NV92 A0A3B3IRK3 NDFIP2 NEDD4 family-interacting protein 2 1 10672300.0 2887700.0 3423800.0 4360800.0 True False 2796031.544147066 4790941.194881128 3218575.6588042136 1.0 1.7134789501606331 1.1511227995770146 21.4149492062635 -10.236100629351128 4.195756234069446 0.9997394503895612 1.4323008745681987 0.44069423029330257 0.22958093723968187 161961637.74694693 199.97768955195568 421774.1711422116 0.07859166129196216 5.806298655554722e-11 10.236100629351128 0.4325614241786374 AK(ub)AAAMAAAAAETSQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKAAAMAAAAAETSQR 16 1 A0A3B3IRK3;H7C5F7;B4DGY6;A0A0C4DGW0;Q9NV92 A0A3B3IRK3 NDFIP2 NEDD4 family-interacting protein 2 1 12462400.0 4446300.0 3523400.0 4492700.0 True False 6090217.266739508 3367724.5376743097 3431616.790060925 1.0 0.5529728070731494 0.56346377144901 22.538062266102163 -9.956279573008297 5.145742661736221 1.0000018814427354 0.5582182892566384 0.9995772401121724 0.004282918287237084 9.244076039936628e-08 1.8757813223317184e-08 0.004146935464191262 0.0013823059310792453 1.1059116345176493e-10 9.956279573008297 -0.441783592186097 AK(ub)AAAMAAAAAETSQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKAAAMAAAAAETSQR 16 1 A0A3B3IRK3;H7C5F7;B4DGY6;A0A0C4DGW0;Q9NV92 A0A3B3IRK3 NDFIP2 NEDD4 family-interacting protein 2 1 11497500.0 2887700.0 6101500.0 2508300.0 True False 2401250.4968006946 6068630.008447075 3032773.9329311596 1.0 2.527279022547882 1.26299773262801 21.195354481697777 -6.5995470949451285 2.19211174271869 2.0274068335651827 1.2670458289925675 0.019321757169487586 0.6602075560322875 0.6419886966627036 5.829460901904643 0.2500441523985843 0.7345735621696933 2.514507324738167e-07 6.5995470949451285 -0.7603610045726152 AK(ub)AEASSGDHPTDTEMKEEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKAEASSGDHPTDTEMKEEQK 21 2 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 1 3902050.0 1362700.0 1619100.0 920250.0 True False 1786512.896405571 1377536.5912023694 825031.3576613216 1.0 0.7710756490893216 0.4618110282446148 20.76871489775237 -6.966938023147407 0.3230658770606903 1.040858489278673 0.18200779458415495 0.9999477012941718 0.0015948095114076612 0.07730931807113561 0.012572944247069949 0.004631020829276055 0.027130965903468206 1.0791007064418333e-07 6.966938023147407 -0.858850694694518 down AK(ub)AEASSGDHPTDTEMKEEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKAEASSGDHPTDTEMKEEQK 21 2 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 1 7546500.0 2844600.0 2423000.0 2278900.0 True False 4315466.168116221 1990596.7190145936 1828474.4161226468 1.0 0.46127037994681463 0.4237026418216155 22.041084980896073 -13.999999999999998 0.37816672614654406 8.900717906542786 0.42029563506382617 0.9998045475786237 0.0036805045096969225 23.805259226150106 0.20037060680581514 153.00053448872941 0.01023890751484437 1.0000000000000041e-14 13.999999999999998 -8.48042227147896 AK(ub)AEASSGDHPTDTEMKEEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKAEASSGDHPTDTEMKEEQK 21 2 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 1 8892000.0 2844600.0 3070700.0 2976700.0 True False 3682390.775448932 2899812.8456377615 2434971.1435212544 1.0 0.787481020474867 0.6612473504321115 21.812211302988523 -13.999999995703533 0.05470301634285217 2.439645977334509 0.01315868951231531 0.9999665597383137 0.0008083080704217438 12.518140447674517 0.057742137879906154 2.590893504424831 0.6140997762466458 1.0000000098929814e-14 13.999999995703533 -2.4264872878221935 AK(ub)AIAINTFLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKAIAINTFLPK 12 1 Q92615 Q92615 LARP4B La-related protein 4B 1 3190900.0 1293900.0 1897000.0 0.0 True False 1962940.8967607308 1558465.5286713508 0.0 1.0 0.7939441942664447 0.0 20.904585303904177 -7.260245684063689 0.8456710057937656 0.9891499548670963 4.819819575212898e-17 0.9887091152342914 0.045810556474429616 0.09955207230943094 0.13791888223738885 0.03886657347376037 0.0685023943938861 5.4923008185184144e-08 7.260245684063689 -0.9891499548670963 down AK(ub)ALDQSDNDMSAVYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKALDQSDNDMSAVYR 16 1 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 1 14839500.0 2910000.0 3280100.0 8649400.0 True False 2817623.642853464 4589861.035495528 6383862.663561991 1.0 1.6289830074137523 2.2656903379391458 21.426047489399636 -6.97097337751033 0.2337715592659596 0.7529673952137819 3.1599816569982386 0.9999890109546805 0.0017129001630728983 0.0759881148872396 0.007890999471437652 0.015914754068023576 0.06278375797070364 1.0691204148811031e-07 6.97097337751033 2.4070142617844565 AK(ub)ALDQSDNDMSAVYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKALDQSDNDMSAVYR 16 1 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 1 28331900.0 5482000.0 9088900.0 13761000.0 True False 8316594.787883395 7466914.783100174 11041132.318339452 1.0 0.8978331845599672 1.327602534444204 22.987561510161658 -6.843997282883886 1.2637781539466302 0.9456474241827175 1.34288757868143 0.9311040636745392 0.04811846863988889 0.16417717693710904 0.507627102649738 0.02983523872521275 0.06882340378201032 1.4321968596291426e-07 6.843997282883886 0.3972401544987125 AK(ub)ALDQSDNDMSAVYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKALDQSDNDMSAVYR 16 1 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 1 8947700.0 2920900.0 2481600.0 3545200.0 True False 4000835.664354508 2371954.706446207 2707896.7756858887 1.0 0.5928648176127715 0.6768327926617749 21.931869940049697 -9.907032917972767 5.461642353115077 1.0000003918117177 0.6348488051356515 0.9618537182811193 0.034279782273194094 1.6354791903329766e-07 3.2691036021617237e-08 0.03319129207097868 0.011063752153811767 1.238702693725835e-10 9.907032917972767 -0.3651515866760663 AK(ub)ALDQSDNDMSAVYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKALDQSDNDMSAVYR 16 1 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 1 11568000.0 2910000.0 4740900.0 3917100.0 True False 2419793.9348581946 4715359.830705024 4736147.4993759245 1.0 1.9486617280827903 1.9572524053183369 21.206452764833912 -11.025262862075783 0.7834047826101913 1.1528514201231848e-08 1.9554593749012792 0.9999895079435311 0.001455148124846021 3.240331263728439 0.4150872051116728 5.822088591112156 0.0012538290857219707 9.43489644721139e-12 11.025262862075783 1.955459363372765 AK(ub)ALDQSDNDMSAVYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKALDQSDNDMSAVYR 16 1 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 1 5859400.0 0.0 2156400.0 3703000.0 True False 0.0 2036394.4443720528 3029091.995988583 0.0 AK(ub)AQELIQATNQILSHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKAQELIQATNQILSHR 17 1 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 6923300.0 2716400.0 1539900.0 2667000.0 True False 2630169.3688821853 2154790.100472415 1968432.6917150128 1.0 0.8192590659620504 0.7484052985346686 21.32672427370065 -13.999999999999945 0.12943557962487998 1.8588699115053737 0.6484645270987223 0.9996481764760692 0.0019868863273713416 11.937517443521065 0.11182327070093667 2.609737003852829 0.08886136189407301 1.0000000000001268e-14 13.999999999999945 -1.2104053844066516 AK(ub)AQIALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKAQIALK 8 1 P40925;P40925-3;A0A5K1VW95;P40925-2;B9A041;C9JF79 P40925 MDH1 Malate dehydrogenase, cytoplasmic;Malate dehydrogenase 1 5356100.0 1630700.0 1992100.0 1733300.0 True False 1578934.321100053 2787555.9186642612 1279296.732114597 1.0 1.7654666704072621 0.8102279588319439 20.59051973001316 -6.693340578553094 1.8546187571448705 1.4783879158161908 0.8133954514016072 0.38609378216124035 0.32352199938329135 0.40951560536912923 2.7335179831214687 0.1394201728320485 0.36152873584529216 2.0260932115630284e-07 6.693340578553094 -0.6649924644145836 AK(ub)ASLNGADIYSGCCTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKASLNGADIYSGCCTLK 18 1 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;B4DVF8;M0R1W6 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 13012300.0 5450400.0 4856400.0 2705500.0 True False 7145527.181748687 4131844.050098937 2425560.8129885425 1.0 0.5782420169994753 0.3394516249527369 22.768609023533642 -9.250018479088144 0.16347561025165247 1.5169620836333668 7.763383972939737e-08 0.9997554754178647 0.00427044968524575 0.6863753896136214 0.05878083887683124 0.34097378898700054 0.16799054235971264 5.623173982599533e-10 9.250018479088144 -1.516962005999527 AK(ub)ASLNGADIYSGCCTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKASLNGADIYSGCCTLK 18 1 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;B4DVF8;M0R1W6 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 25933800.0 10063000.0 5897200.0 9973600.0 True False 13026751.871385291 5569015.6359445695 8158507.137777943 1.0 0.42750608063530643 0.626288672596813 23.634974067134166 -10.088736529776138 5.004488960812497 1.00001301255998 0.5268973766142486 0.8830756031985877 0.08115265334906585 112852526.66262703 5.062796085322244 16929.08674427923 0.027780711774391953 8.151986846000993e-11 10.088736529776138 -0.47311563594573136 AK(ub)AVPLIHQEGNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKAVPLIHQEGNR 13 1 O00170;E9PMH2;V9GYQ3 O00170 AIP AH receptor-interacting protein 1 17536400.0 2887200.0 3719200.0 10930000.0 True False 3737537.315220471 3512223.2505604466 8940852.15127063 1.0 0.9397159023021732 2.392177360975251 21.833656552438203 -6.897217450956085 0.9787051467641887 0.9349155749808047 2.536300620322498 0.9851299475637363 0.08181623678759882 0.11348207271826241 0.18920218987449872 0.06301211719471396 0.16177126164541072 1.2670173122915438e-07 6.897217450956085 1.6013850453416933 up AK(ub)CHEIFCCPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKCHEIFCCPLK 12 1 A0A0C4DG13;B1B1H9;B1AJW0;Q92913-5;Q92913-3 A0A0C4DG13 FGF13 Fibroblast growth factor 1 9913000.0 3774900.0 3883600.0 2254500.0 True False 4948930.456183597 3304182.01815423 2021225.9666910658 1.0 0.6676557788412071 0.40841672449965044 22.23868533849939 -7.572927521513892 0.1888414443923143 1.2250724553228902 4.043892818261089e-15 0.9999512150550512 0.0016911540950418984 0.13260525768923856 0.019571111021017037 0.03930223729369418 0.07269200794999521 2.673452538266336e-08 7.572927521513892 -1.2250724553228862 down AK(ub)CHEIFCCPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKCHEIFCCPLK 12 1 A0A0C4DG13;B1B1H9;B1AJW0;Q92913-5;Q92913-3 A0A0C4DG13 FGF13 Fibroblast growth factor 1 7627400.0 3774900.0 2011500.0 1841000.0 True False 5170582.542836732 1922625.2788590188 1406193.716585164 1.0 0.3718392005021954 0.271960403868475 22.301895400022282 -13.999999999999998 0.2588152601716264 5.570173048136167 0.23503898030425852 0.9995599257339309 0.006760133243167025 14.365071523981019 0.16098665874342957 34.31188870593478 0.0439398627084462 1.0000000000000041e-14 13.999999999999998 -5.335134067831908 AK(ub)DPFAHLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKDPFAHLPK 10 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 8577700.0 2303700.0 2724300.0 3549700.0 True False 2230570.304481627 3812127.1970368167 2619927.0812826306 1.0 1.7090370069831695 1.1745548104978867 21.088981189898583 -10.611430955366615 5.3057676514759615 0.9961667723317958 1.4417959087405245 0.47671218389133896 0.2182014429984898 0.009957937066718976 0.0007292709273520699 0.212637777437707 0.07042421290429775 2.4466342138388214e-11 10.611430955366615 0.4456291364087287 AK(ub)DPFAHLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKDPFAHLPK 10 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 15947200.0 4245600.0 4742500.0 6959100.0 True False 6440885.594935745 3896163.8216783754 5583630.834718113 1.0 0.6049111980411203 0.8669042094317491 22.618827635860136 -10.181894590910126 5.2232700429789185 1.000014078949704 0.7359077037363109 0.5753330092556665 0.10695819901413617 1.753687176534214e-05 2.7467539940972465e-06 0.10356734961030584 0.03452061029344503 6.578174790973219e-11 10.181894590910126 -0.2641063752133932 AK(ub)DPFAHLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKDPFAHLPK 10 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 11224500.0 4245600.0 3564200.0 3414700.0 True False 5496012.893287625 3365849.136816396 2793259.637780776 1.0 0.6124165285214606 0.5082338218660716 22.389953957952585 -13.999999999999998 0.18438981948760305 3.039012239937552 0.42912140753961997 0.9994934954273631 0.0047618265586991376 12.264702683861898 0.13615612296599877 8.969558388314447 0.07497891019922895 1.0000000000000041e-14 13.999999999999998 -2.609890832397932 AK(ub)EAQDDLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKEAQDDLVK 10 1 P15311;E7EQR4 P15311 EZR Ezrin 1 7411300.0 2681800.0 2827600.0 1901900.0 True False 3515865.7705881395 2405733.101898474 1705109.6323130354 1.0 0.6842505541660765 0.4849757481008162 21.745448561363105 -8.858791766873713 0.11930350622145323 1.555045902089078 2.3570301700978896e-12 0.9999403726397993 0.0016373554811460291 0.36500001157682094 0.03567389265478109 0.2532463765476085 0.18519177376384716 1.384229922822581e-09 8.858791766873713 -1.5550459020867209 AK(ub)EAQDDLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKEAQDDLVK 10 1 P15311;E7EQR4 P15311 EZR Ezrin 1 8624500.0 4196000.0 4428500.0 0.0 True False 4062800.2767742784 6196823.144322418 0.0 1.0 1.5252591124765993 0.0 21.95404301418126 -6.833212899595254 1.445276433977398 1.2836887778189052 1.0161207589424798e-22 0.868652949720659 0.22928708840880624 0.19136195726099559 0.8019537632008872 0.12701925893098592 0.2741212271042937 1.4682063579086986e-07 6.833212899595254 -1.2836887778189052 down AK(ub)EAQDDLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKEAQDDLVK 10 1 P15311;E7EQR4 P15311 EZR Ezrin 1 12036300.0 4827300.0 3808200.0 3400800.0 True False 7323367.022902132 3128596.956397596 2728630.389376411 1.0 0.42720745070042704 0.37259233093783944 22.80407567007388 -13.999999999999998 0.33239906532132746 7.32614360724502 0.36318959202754886 0.9997197998218028 0.004750027273097779 19.02782582998461 0.18449318188339708 84.2567766982198 0.017346236418500305 1.0000000000000041e-14 13.999999999999998 -6.962954015217471 AK(ub)EAQDDLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKEAQDDLVK 10 1 P15311;E7EQR4 P15311 EZR Ezrin 1 7814200.0 2681800.0 2791200.0 2341200.0 True False 3673333.9329199567 2667875.554735912 1788256.7785275334 1.0 0.7262817929039195 0.48682118510963596 21.808658622885996 -6.972694131368377 0.18270777094662757 1.178603431277796 0.028006481574217017 0.9999964853426827 0.0003930158377060251 0.07543776303071147 0.0057796840826782065 0.009004075093059675 0.02665516431102288 1.064892745950642e-07 6.972694131368377 -1.150596949703579 down AK(ub)EAQDDLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKEAQDDLVK 10 1 P15311;E7EQR4 P15311 EZR Ezrin 1 10033700.0 4196000.0 4651600.0 1186100.0 True False 3489159.9143178686 4626540.907529693 1434108.0260932292 1.0 1.3259755990387683 0.41101814227783756 21.734448289615536 -6.810374885981145 1.412897156152814 1.1775765130409221 0.39486493246802334 0.8608148932638312 0.14126079067056824 0.2062923158581535 0.8115762535572272 0.07861164485348128 0.18181925532582222 1.5474802466297948e-07 6.810374885981145 -0.7827115805728988 down AK(ub)EEQQDDTVYMGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKEEQQDDTVYMGK 14 1 E7EX90;Q14203-5;Q14203-2;Q14203-3;Q14203-4;Q14203-6;Q14203;E7EWF7 E7EX90 DCTN1 Dynactin subunit 1 1 34747100.0 2294800.0 7038200.0 25414100.0 True False 3481379.37235221 5782178.220292411 20390991.995604247 1.0 1.660887137498507 5.857158848455801 21.73122760510049 -6.934648716313568 0.7075916479843537 0.9458492933744734 6.830354232729869 0.9973756445469399 0.11018746416034828 0.09029478971450816 0.06637448269074671 0.1033234562767619 0.37046632733371987 1.1623884438840274e-07 6.934648716313568 5.884504939355396 AK(ub)EEQQDDTVYMGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKEEQQDDTVYMGK 14 1 E7EX90;Q14203-5;Q14203-2;Q14203-3;Q14203-4;Q14203-6;Q14203;E7EWF7 E7EX90 DCTN1 Dynactin subunit 1 1 8949100.0 2294800.0 3471100.0 3183200.0 True False 2970663.8372706887 3277930.233657872 2603890.262390181 1.0 1.1034335802429553 0.8765348100721209 21.50235392719294 -6.782786857083619 1.52522812010225 1.0583553220494408 0.8745848947488654 0.7770510796656129 0.043794807994983365 0.24627222199991802 1.1317879373172854 0.022612462986826665 0.053228151685158785 1.6489714746973226e-07 6.782786857083619 -0.18377042730057547 AK(ub)EFTNVYIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKEFTNVYIK 10 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 128497300.0 46134000.0 54649000.0 27714300.0 True False 60482120.76229153 46495582.22013354 24846690.0903376 1.0 0.7687492044611289 0.41081049700606126 25.85000539172685 -6.964730218468478 0.3626525084051391 1.029923882333782 0.1373189410211424 0.9999074754333818 0.0023314578519103356 0.07805262600768428 0.015183461838056234 0.004777384222129443 0.030524670732372063 1.0846004531056442e-07 6.964730218468478 -0.8926049413126396 down AK(ub)EFTNVYIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKEFTNVYIK 10 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 139603000.0 55581000.0 48920000.0 35102000.0 True False 53816611.57850122 68454011.1144299 25907733.162572347 1.0 1.2719866432797875 0.48140773643433965 25.681548222548024 -6.81380045728268 1.3982961526713715 1.147578931638103 0.46631245368059776 0.8695784633127167 0.11843370191156362 0.20165357841036366 0.7763043205976011 0.06658246862971565 0.1537858618032167 1.5353222461983372e-07 6.81380045728268 -0.6812664779575053 down AK(ub)EFTNVYIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKEFTNVYIK 10 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 234606000.0 62900000.0 106988000.0 64718000.0 True False 95423898.60595873 87895155.49894059 51926458.93309287 1.0 0.92110212203646 0.5441661857425969 26.507847293989897 -6.940826753068149 0.6518381774182248 1.0041781799553073 0.44000173852525964 0.9982700432322379 0.008273250588064421 0.08739181782379277 0.05290960049371622 0.00810467431577769 0.03232584767119395 1.1459699958171064e-07 6.940826753068149 -0.5641764414300476 AK(ub)EFTNVYIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKEFTNVYIK 10 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 125966900.0 46134000.0 56993000.0 22839900.0 True False 63190986.52447218 54474860.80935223 17445586.022505984 1.0 0.8620669466563173 0.27607712716670085 25.91321545324974 -6.94349395749017 0.6262261948274768 1.0063949038539939 0.1003717735850939 0.9985865401234497 0.011799223233187352 0.08620847958389573 0.04762020046121441 0.011816113287910482 0.049711329492705424 1.1389536284749758e-07 6.94349395749017 -0.9060231302689 down AK(ub)EFTNVYIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKEFTNVYIK 10 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 137908200.0 55581000.0 68139000.0 14188200.0 True False 46218064.155791566 67771921.68246743 17154887.021175224 1.0 1.466351369759284 0.3711727726922884 25.4619534979823 -6.790998716299538 1.49223743095229 1.2603123091532114 0.3591862195920096 0.8045581892865478 0.1983834039696296 0.23387466466662898 1.0287895585724018 0.1046333568411294 0.24480618567980458 1.6180848204189202e-07 6.790998716299538 -0.9011260895612018 down AK(ub)EFTNVYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKEFTNVYIK 10 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 224192000.0 62900000.0 126795000.0 34497000.0 True False 81425289.94436395 119738746.78823718 28218899.96911099 1.0 1.470535098739617 0.34656186042926374 26.278973616082347 -6.792973653279387 1.4843248210894897 1.2619628292301623 0.3335889588483578 0.8108678043235826 0.20043400602084918 0.23093374241779138 1.0050357357231996 0.1062682125026066 0.2482833779794595 1.6107433488714663e-07 6.792973653279387 -0.9283738703818045 down AK(ub)EILQEEEDLAEIVQLVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKEILQEEEDLAEIVQLVGK 20 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 465193000.0 94894000.0 182741000.0 187558000.0 True False 143961135.68066525 150129440.7880502 150487079.09040818 1.0 1.04284701616322 1.0453312859674766 27.10110414765229 -13.999994316651804 0.40539537981839585 0.2522211105642067 1.045458854618255 0.9998451801897541 0.0002588494316899196 27.571116591555878 0.21040740192678162 18.17124218654762 0.0006262550564810601 1.0000130864784607e-14 13.999994316651804 0.7932377440540483 AK(ub)EILQEEEDLAEIVQLVGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKEILQEEEDLAEIVQLVGK 20 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 366859000.0 94894000.0 122317000.0 149648000.0 True False 122842153.64038906 115509951.42471547 122413599.51814726 1.0 0.9403120020417581 0.9965113431379886 26.87223046974474 -10.188091214365343 5.067011414462883 1.00000242980739 0.9684116728541332 0.29638902983507676 0.02294328492783713 6.298291061499423e-07 1.0091696785493724e-07 0.02221644897767394 0.007404913369385273 6.484982159172503e-11 10.188091214365343 -0.03159075695325675 AK(ub)FEELNMDLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKFEELNMDLFR 12 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 10294200.0 1229200.0 3113600.0 5951400.0 True False 1611493.103589733 2649063.016717744 5335606.217859922 1.0 1.6438562540644692 3.310970556420268 20.61996658369856 -6.954705866224916 0.5045494745407507 0.9678896500549878 4.059399295046781 0.999520680736844 0.021319539396555905 0.08164943201710244 0.0285550660415842 0.024793481042120785 0.13754753631498312 1.109926278364293e-07 6.954705866224916 3.0915096449917927 AK(ub)FEELNMDLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKFEELNMDLFR 12 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 20916700.0 2303600.0 3799100.0 14814000.0 True False 2230473.4789268896 5316100.442044769 10933768.989526127 1.0 2.383395495292962 4.901994618105259 21.08891856341274 -6.961840402955414 0.40866945927037657 0.8741172570756368 6.504538459877478 0.9998324840274666 0.02090647106051334 0.0790501235448645 0.018749562651997655 0.03242082290468415 0.21037562824953662 1.0918414989537224e-07 6.961840402955414 5.630421202801841 AK(ub)FEELNMDLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKFEELNMDLFR 12 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 12304400.0 1229200.0 1649700.0 9425500.0 True False 1683668.4578809813 1576810.7991716256 7199391.024265872 1.0 0.9365328380363889 4.2760146693766705 20.68317664522145 -6.902570582019928 0.9448919077978856 0.8707789509858954 4.645415865815778 0.9878018876989814 0.17223938054554436 0.10953720604575522 0.16694803538015354 0.13602754688435667 0.3587032753106911 1.251495862010081e-07 6.902570582019928 3.7746369148298826 up AK(ub)FEELNMDLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKFEELNMDLFR 12 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 20835000.0 2303600.0 3828600.0 14702800.0 True False 1915545.4667832803 3807974.571882402 17777087.50193368 1.0 1.9879322302263192 9.280430984384946 20.869323838847016 -6.931624809067383 0.7333307878765463 0.8955174688101796 10.841440487086258 0.9968480822828405 0.20731348113506548 0.09180288128360486 0.07361069886668012 0.19073181967145952 0.6540494716203513 1.1705101686730685e-07 6.931624809067383 9.945923018276078 AK(ub)FENLCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKFENLCK 8 1 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 8677600.0 3591500.0 2816100.0 2270000.0 True False 4708491.280135474 2395948.857071822 2035122.1753775633 1.0 0.5088570233059633 0.43222383865581 22.166833427176687 -13.999999999999998 0.261503001500581 4.623750020754579 0.4046155189706717 0.9995654160315148 0.005243827638593366 14.484056877704694 0.1618284333335057 27.76132937236387 0.03323977127391088 1.0000000000000041e-14 13.999999999999998 -4.219134501783907 AK(ub)FENLCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKFENLCK 8 1 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 13158500.0 10103800.0 2040700.0 1014000.0 True False 9783060.399540506 2855562.1521099135 748402.9806520529 1.0 0.2918884311747717 0.07649988348096104 23.221854418199946 -10.165506017360917 0.28643366188872327 1.5762459615643247 2.4827668393327307e-16 0.9989132601654744 0.01300495624518379 1.6719732532442024 0.1361505037371885 0.8319816136223304 0.0808629363403534 6.831152530202077e-11 10.165506017360917 -1.5762459615643245 AK(ub)FENLCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKFENLCK 8 1 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 23280900.0 5100800.0 4718100.0 13462000.0 True False 7738286.51843044 3876118.192316445 10801229.7993958 1.0 0.5009013536891679 1.395816731994904 22.883582716438994 -6.75537192383125 1.630157637725627 0.7084288633226846 1.398329035032024 0.6716839754700779 0.20980427942347615 0.29076462735218844 1.5217847370937219 0.10160713566283405 0.24528095691932342 1.7564187967571176e-07 6.75537192383125 0.6899001717093395 AK(ub)FENLCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKFENLCK 8 1 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 8507200.0 3591500.0 2345300.0 2570400.0 True False 4919374.606638093 2241676.891130031 1963324.4590497068 1.0 0.4556833074076455 0.3991004174393309 22.23004348869958 -13.99999999999997 0.31985788428209944 6.5763930049558965 0.3878491629956224 0.999693422010446 0.00474357638180828 18.002261882929304 0.18035547942175148 67.17319413088478 0.018848885177689716 1.0000000000000696e-14 13.99999999999997 -6.188543841960274 AK(ub)FENLCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKFENLCK 8 1 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 14018400.0 10103800.0 1712500.0 2202100.0 True False 8401757.374233767 1703274.4225953633 2662548.9286399977 1.0 0.2027283515492734 0.31690381072005425 23.002259693634223 -10.806772669240708 7.354619543141026 1.0280689483627363 0.2598160811346755 0.9824674263016167 0.04661193601939787 0.01816165563996415 0.00047715915980374164 0.03820787154035594 0.015043937661467794 1.5603690618112154e-11 10.806772669240708 -0.7682528672280609 AK(ub)FENLCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKFENLCK 8 1 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 21133400.0 5100800.0 4484600.0 11548000.0 True False 6603086.1517998725 4235028.067719775 9446382.492486116 1.0 0.6413710150617056 1.4306011273094197 22.654709038531443 -6.783158935936635 1.5235206465503024 0.7977685838434563 1.4374883363176907 0.7784224194635297 0.1518770100197429 0.2456969109475956 1.1265926215802642 0.07850035831457225 0.18474819067680098 1.6475593345729026e-07 6.783158935936635 0.6397197524742344 AK(ub)FLQFVTGTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKFLQFVTGTSK 12 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 18149000.0 4629300.0 8046400.0 5473300.0 True False 6069057.1302049635 6845908.484621544 4906975.419600886 1.0 1.1280019841220945 0.8085235176283747 22.53304097060975 -6.7979558419940505 1.4641220387655416 1.0708086463506121 0.80432657854584 0.8261533577980208 0.054737849839747894 0.2236881907356728 0.9468503048963537 0.02941376516027825 0.0684962212302586 1.5923706271901427e-07 6.7979558419940505 -0.2664820678047721 AK(ub)FLQFVTGTSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKFLQFVTGTSK 12 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 9939000.0 2894100.0 3568000.0 3476900.0 True False 2802228.3796502445 4992721.006874195 2566195.5852358188 1.0 1.7816966822302163 0.9157696081702357 21.418143108519814 -6.6689579488017765 1.9413857154320766 1.4994181214992632 0.9193134083640343 0.2742552750848515 0.3321311705403621 0.463544815948413 3.367318429847291 0.1377876915783836 0.36859233463925056 2.1430980996813003e-07 6.6689579488017765 -0.5801047131352289 AK(ub)FLQFVTGTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKFLQFVTGTSK 12 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 12459300.0 4629300.0 3835100.0 3994900.0 True False 6340877.312128553 3665652.601020242 3051386.8975481093 1.0 0.5780986479597613 0.4812247181808028 22.596251032132642 -13.999999999999998 0.2067253921308248 3.4077649842263007 0.42232127986108553 0.9994884357810977 0.0050939557721099175 12.672006557634461 0.1441331737954988 12.373567906193477 0.05872864876144365 1.0000000000000041e-14 13.999999999999998 -2.985443704365215 AK(ub)FLQFVTGTSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKFLQFVTGTSK 12 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 16811500.0 2894100.0 8918600.0 4998800.0 True False 2406572.3803687636 8870553.731596502 6044025.968160221 1.0 3.685970055983627 2.5114665228702093 21.19854838395409 -9.758522534853975 6.983754864810594 0.9999999955582526 3.098718289427042 0.8097897560066529 0.4794890595377684 3.4028407298868454e-08 5.943560905304097e-09 0.4642632855694063 0.15475442852313623 1.7437228760954608e-10 9.758522534853975 2.0987182938687896 AK(ub)HDELTYF ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKHDELTYF 9 1 P04080;A0A1W2PQG6 P04080 CSTB Cystatin-B 1 182038000.0 63403000.0 85408000.0 33227000.0 True False 83121946.99552536 72665459.31777643 29788988.775890004 1.0 0.8742030467800299 0.3583769371703193 26.308726111618864 -6.944304927829084 0.6182169465355465 1.0056531330408573 0.1996827332723451 0.9986751359548561 0.010104460122547641 0.08585640785576938 0.04607027100297291 0.010192581070486595 0.0436253810805625 1.1368288127125806e-07 6.944304927829084 -0.8059703997685123 down AK(ub)HDELTYF ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKHDELTYF 9 1 P04080;A0A1W2PQG6 P04080 CSTB Cystatin-B 1 206060000.0 85174000.0 69170000.0 51716000.0 True False 82470197.9918904 96789941.71678485 38170028.15325598 1.0 1.1736353746392432 0.46283420050730784 26.29736953536517 -6.842138811316144 1.272530812830991 1.092356409576932 0.4384634740782788 0.9280523451141501 0.08115839483438907 0.16631667905449724 0.5222506458420351 0.04999262560469389 0.11524095403783256 1.4383387759372514e-07 6.842138811316144 -0.6538929354986532 down AK(ub)HDELTYF ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKHDELTYF 9 1 P04080;A0A1W2PQG6 P04080 CSTB Cystatin-B 1 563630000.0 146230000.0 259380000.0 158020000.0 True False 221841600.84498146 213091612.4548101 126787277.73737374 1.0 0.9605574952721079 0.5715216499270134 27.724954691347957 -6.926421948733157 0.7756043016357269 1.006766592815225 0.4984766739166466 0.9957869427866504 0.01255072497744379 0.09453894565630656 0.08709884703136196 0.011199656606566947 0.035918514185035215 1.184617246903946e-07 6.926421948733157 -0.5082899188985783 AK(ub)HDELTYF ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKHDELTYF 9 1 P04080;A0A1W2PQG6 P04080 CSTB Cystatin-B 1 158952000.0 63403000.0 54243000.0 41306000.0 True False 86844802.50164968 51846364.90238618 31550373.52377337 1.0 0.5970002050658278 0.36329604783399727 26.371936173141755 -9.181639636409034 0.15581202918436196 1.5203027429586218 1.6581927619459556e-10 0.9998003308439567 0.0037159932843276434 0.6250674424263946 0.05442940087555959 0.3227849575841281 0.17213973746193945 6.582037671398888e-10 9.181639636409034 -1.5203027427928024 AK(ub)HDELTYF ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKHDELTYF 9 1 P04080;A0A1W2PQG6 P04080 CSTB Cystatin-B 1 210722000.0 85174000.0 101910000.0 23638000.0 True False 70825954.84797662 101360990.60244869 28580596.51023673 1.0 1.4311277669325257 0.40353280900459654 26.077774810799447 -6.792733428758889 1.4852490143612913 1.2401124427501267 0.3917470940650732 0.8100661858950453 0.18361718530435933 0.2313222171068855 1.007984753197787 0.09729039409207003 0.22734987548133023 1.6116345577170682e-07 6.792733428758889 -0.8483653486850535 down AK(ub)HDELTYF ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKHDELTYF 9 1 P04080;A0A1W2PQG6 P04080 CSTB Cystatin-B 1 732902000.0 146230000.0 489920000.0 96752000.0 True False 189297617.6242342 462655521.3257081 79144128.75935383 1.0 2.4440641521654216 0.41809363346800865 27.496081013440406 -6.7153044293997635 1.7758273695506228 1.882948113616248 0.4219866588418678 0.49030914500725253 0.6080490747801316 0.3645923761862719 2.2442727445120587 0.27212489134053347 0.687036201957331 1.9261742406391114e-07 6.7153044293997635 -1.46096145477438 AK(ub)HLAAVEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKHLAAVEER 10 1 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 1 25895800.0 7206700.0 13297000.0 5392100.0 True False 9448053.48978207 11313139.431300033 4834177.216675493 1.0 1.19740425300672 0.5116585360046473 23.17158570184342 -6.82971730549773 1.3290621267527856 1.105505003587157 0.493298517626734 0.9053200056485559 0.08868895081564873 0.18116729208884486 0.6259490108974508 0.0523937953392539 0.12058117660612505 1.4800714948728571e-07 6.82971730549773 -0.612206485960423 AK(ub)HLAAVEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKHLAAVEER 10 1 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 1 33435300.0 11756000.0 13211000.0 8468300.0 True False 11382812.21490907 18486221.194454875 6250198.186445539 1.0 1.6240469266673703 0.5490908633508954 23.440353695255325 -6.749325753642614 1.6524785603379786 1.367240695188223 0.5470799338244859 0.6460362681284915 0.26221898893418416 0.30120830878829385 1.6180954081004895 0.12536746560528095 0.30455756327432254 1.7810423501055297e-07 6.749325753642614 -0.8201607613637371 AK(ub)HLAAVEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKHLAAVEER 10 1 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 1 22195000.0 7206700.0 9682700.0 5305600.0 True False 9871211.743744599 9254886.297592947 4052526.552261951 1.0 0.9375633445871305 0.4105399273630254 23.23479576336631 -6.929111598759053 0.7540500864564456 1.0082842094065594 0.3047529521337217 0.9963607162110159 0.015949672352563588 0.0931017915433986 0.07995973706219717 0.014454855023810347 0.04792162515500222 1.1773034081254612e-07 6.929111598759053 -0.7035312572728376 down AK(ub)HLAAVEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKHLAAVEER 10 1 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 1 28709100.0 11756000.0 14202000.0 2751100.0 True False 9775634.879104123 14125491.007123709 3326342.2903507957 1.0 1.4449691689403834 0.34026867118994064 23.2207589706896 -6.797367697477229 1.46666370266828 1.2463260603073472 0.32599326750267044 0.8243772895100449 0.19018568142810155 0.22451801041896238 0.9537391203617731 0.10202783150746769 0.23766681632310713 1.594528560429568e-07 6.797367697477229 -0.9203327928046767 down AK(ub)IDNYIPIF ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKIDNYIPIF 10 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 40839800.0 14303000.0 18632000.0 7904800.0 True False 18751371.51044905 15852178.226967165 7086887.124195833 1.0 0.8453876676771971 0.37793966805290596 24.160492785097908 -6.9512762032496 0.5446532352808737 1.0066791732256106 0.19488857218034067 0.9992976637730534 0.00700817157020021 0.08297730303684234 0.033872629502174186 0.007659861048392868 0.03874126737197966 1.1187261680423785e-07 6.9512762032496 -0.81179060104527 down AK(ub)IDNYIPIF ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKIDNYIPIF 10 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 74841000.0 30135000.0 30051000.0 14655000.0 True False 29178380.920065034 42050521.01389476 10816415.859423885 1.0 1.4411533364066123 0.37069965907483865 24.798396495945802 -6.7948048087582755 1.477092733020134 1.2450357946187738 0.3577644915739651 0.8164896623119375 0.18816861529538928 0.22827721939830928 0.9837424922097067 0.10024563706264006 0.23390409983210883 1.6039661223747116e-07 6.7948048087582755 -0.8872713030448087 down AK(ub)IDNYIPIF ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKIDNYIPIF 10 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 65048000.0 21717000.0 17795000.0 25536000.0 True False 32946276.725367326 14619343.217030395 20488798.40717361 1.0 0.44373278774090064 0.6218850942691818 24.973612098993947 -10.65343011910726 7.610498370133985 1.0010762793531962 0.5328089410050427 0.9016665904917451 0.07273037458236489 0.0013307624302424303 6.060074334900752e-05 0.0705579819119916 0.023473627460077202 2.2211090460301447e-11 10.65343011910726 -0.4682673383481535 AK(ub)IDNYIPIF ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKIDNYIPIF 10 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 39042600.0 14303000.0 16542000.0 8197600.0 True False 19591205.62404141 15811119.742921151 6261495.714871556 1.0 0.8070519010590388 0.31960747260943156 24.2237028466208 -6.955237415783918 0.49804509482759046 1.009929611778909 0.09577585477840225 0.9995507467714732 0.0060685255597488184 0.08144845003867758 0.02776830748544901 0.007143252747242462 0.04020731874838656 1.1085686283235669e-07 6.955237415783918 -0.9141537570005067 down AK(ub)IDNYIPIF ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKIDNYIPIF 10 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 69281600.0 30135000.0 30101000.0 9045600.0 True False 25058587.706856288 29938839.93841932 10936993.137871105 1.0 1.1947536823963845 0.43645688519304027 24.57880177138008 -6.8385467394334665 1.2889497013658686 1.1036415710444918 0.41219949886377 0.9219426223248925 0.0898358088790469 0.17051414086557212 0.5508944684907146 0.05466070830234595 0.1258952889195351 1.450284684059685e-07 6.8385467394334665 -0.6914420721807217 down AK(ub)IDNYIPIF ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKIDNYIPIF 10 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 51162000.0 21717000.0 17914000.0 11531000.0 True False 28113084.606069177 16917070.152328417 9432476.318051396 1.0 0.6017507644350163 0.33551908124713825 24.744738421086396 -8.269890697841568 0.1961469910635422 1.290876937871241 5.7784349120620435e-08 0.9997873314053559 0.003981957487414001 0.09042744287096532 0.04262044114530627 0.11491174341695629 0.11820371308683557 5.371669722109136e-09 8.269890697841568 -1.290876880086892 down AK(ub)IQDK(ub)EGIPPDQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKIQDKEGIPPDQQR 15 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 58908930.0 18779730.0 15232100.0 24897100.0 True False 24620407.893164016 12959530.054260777 22320986.921847023 1.0 0.5263734910687267 0.9066050822027429 24.553351327763 -9.922466632359829 6.721225940383425 1.0000000162264775 0.7164892866357315 0.42570926468316395 0.15522889706083057 3.7807115019818535e-08 5.997943704874309e-09 0.15029974225023232 0.05009991109722645 1.1954553711702077e-10 9.922466632359829 -0.28351072959074597 AK(ub)IQDK(ub)EGIPPDQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKIQDKEGIPPDQQR 15 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 72107090.0 13418240.0 9907850.0 48781000.0 True False 12992285.315973245 13864106.173755191 36003792.70136863 1.0 1.0671029643037546 2.7711670291833954 23.631151884376507 -6.915202782682824 0.8595402994184049 0.9555175876433668 3.0177837350147585 0.9927415272006797 0.0698252993683317 0.10107747404624297 0.12084484887666429 0.05868034719564875 0.16846690282434315 1.215618266303722e-07 6.915202782682824 2.0622661473713917 up AK(ub)IQDK(ub)EGIPPDQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKIQDKEGIPPDQQR 15 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 210264300.0 20392300.0 126283200.0 63588800.0 True False 30936609.976824977 103746976.30485488 51020445.80803889 1.0 3.3535340938316485 1.6491931677795006 24.88281177962881 -6.5628212292427595 2.3344710883039874 2.618840865173715 1.6520649364492406 0.0 1.0268585416408555 0.7525274514850653 7.688734291132403 0.3734197365823162 1.1543289034713216 2.7363948900907533e-07 6.5628212292427595 -0.9667759287244744 AK(ub)IQDK(ub)EGIPPDQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKIQDKEGIPPDQQR 15 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 60360630.0 18779730.0 8417600.0 33163300.0 True False 25723103.684120726 8045682.598719198 25330811.559602804 1.0 0.3127803976347506 0.9847494249008494 24.61656138928589 -10.82815424660273 10.764254667188817 1.0049637104853593 0.6487649113295845 0.2670129470315171 0.2743302066260498 0.03264671790518914 0.0005211868167757316 0.2653582459229523 0.08853969346869414 1.4854079822845018e-11 10.82815424660273 -0.3561987991557748 AK(ub)IQDK(ub)EGIPPDQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKIQDKEGIPPDQQR 15 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 70856140.0 13418240.0 9645300.0 47792600.0 True False 11157861.088821886 9593338.85445784 57785811.691984914 1.0 0.8597829618141233 5.178932703318525 23.411557159810783 -6.8993989827949 0.9650906443399685 0.8174520488304862 5.626757690652017 0.9862640082783425 0.23485076377496975 0.11184798651745265 0.17993899555615817 0.18272081599411094 0.4739749594579073 1.2606688362611726e-07 6.8993989827949 4.809305641821531 up AK(ub)IQDK(ub)EGIPPDQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKIQDKEGIPPDQQR 15 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 145162300.0 20392300.0 81187100.0 43582900.0 True False 26398234.34232833 76668966.51580349 35651259.398317784 1.0 2.904321763401744 1.3505168162384507 24.65393810172126 -6.595740453113141 2.206461994631264 2.2841851090455716 1.3552910397657558 0.008586539087680256 0.8239936033280496 0.6529093938991486 6.000697214370037 0.31069645302532384 0.9175354050652358 2.5366441491741665e-07 6.595740453113141 -0.9288940692798158 AK(ub)IQDKEGIPPDQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKIQDKEGIPPDQQR 15 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 433317110.0 210645860.0 110364600.0 112306650.0 True False 276158762.35740966 93898631.87784128 100686235.1794567 1.0 0.34001684783159614 0.364595475153335 28.040922663111267 -10.312000262825528 5.6906862368724145 1.0000787370483786 0.35230616149248917 0.9989211319656509 0.010034182586066717 1.0024892789370096e-05 1.2120045701568818e-06 0.00971672620771162 0.003238518504050722 4.8752819506188954e-11 10.312000262825528 -0.6477725755558894 AK(ub)IQDKEGIPPDQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKIQDKEGIPPDQQR 15 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 230049710.0 76351910.0 65835100.0 87862700.0 True False 73928160.4099725 92123398.75551096 64848823.04550012 1.0 1.2461205343760187 0.8771870243473875 26.139620678719925 -6.726890940739005 1.7343804287352271 1.1486264392269072 0.877522098874094 0.5448160557369375 0.10349150841401673 0.3421284684500369 2.014685563056052 0.04731282846979269 0.117827419965506 1.8754654124908249e-07 6.726890940739005 -0.27110434035281317 AK(ub)IQDKEGIPPDQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKIQDKEGIPPDQQR 15 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 1426816300.0 265959000.0 524285000.0 636572300.0 True False 403479247.2073475 430722245.4925987 510753505.8854495 1.0 1.0675201970703863 1.2658730515152714 28.58791923007158 -6.95192150988651 0.5373334064751671 0.9970274065463625 1.3454840585158863 0.9993435825036235 0.0028909714233031976 0.08272318065461143 0.032839024065896484 0.0031915146661430967 0.01641962088640898 1.1170651169012852e-07 6.95192150988651 0.3484566519695238 AK(ub)IQDKEGIPPDQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKIQDKEGIPPDQQR 15 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 505794660.0 210645860.0 130437200.0 164711600.0 True False 288527326.932324 124674053.20586094 125810112.42188433 1.0 0.4321048357235988 0.4360422763400637 28.10413272463416 -10.003589381295786 5.134604392392299 1.000004330974705 0.43407355602841075 0.9999636956083383 0.001607453412388541 924356.5064787093 1800894.606882154 29.436167795705867 0.000550274182625428 9.917692041581663e-11 10.003589381295786 -0.5659307749462943 AK(ub)IQDKEGIPPDQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKIQDKEGIPPDQQR 15 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 217625860.0 76351910.0 56196400.0 85077550.0 True False 63489996.12812333 55893658.83908801 102866872.35085396 1.0 0.8803537918996585 1.6202059950242835 25.9200259541542 -6.86544552177769 1.1578420223760426 0.9338732942651194 1.6599576551162523 0.9599265160571875 0.06491329288636333 0.14130074909911564 0.3568989042945242 0.04361813347366418 0.10253191250154349 1.3631839942956904e-07 6.86544552177769 0.7260843608511328 AK(ub)IQDKEGIPPDQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKIQDKEGIPPDQQR 15 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 1041115000.0 265959000.0 338183400.0 436972600.0 True False 344289168.335661 319363196.50289935 357448070.5175049 1.0 0.9276016380263804 1.0382204942591013 28.35904555216403 -6.730128600298987 1.7228081070367085 0.9564370163506337 1.038155605229996 0.5598370117794962 0.03043423729603782 0.3359994203302443 1.9538122543770573 0.013999001837963407 0.034731900006387935 1.8615358298385098e-07 6.730128600298987 0.08171858887936234 AK(ub)LAEQAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKLAEQAER 9 1 P27348;E9PG15;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;P31946-2;P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1;P31947-2;P31947 P27348;P31946;P31946-2;P63104;P31947-2 YWHAQ;YWHAB;YWHAZ;SFN 14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma 1 37652000.0 9382000.0 16500000.0 11770000.0 True False 12299892.85541724 14038264.31649626 10552153.305812297 1.0 1.1413322442327933 0.8579061159191166 23.55214241248894 -6.7711296078552605 1.5702056799298945 1.0809474622516304 0.8562462919721945 0.7348389995426537 0.05958262114931672 0.26460517455683047 1.2876950355365404 0.02990743799186943 0.07111638748069365 1.6938322293822294e-07 6.7711296078552605 -0.22470117027943592 AK(ub)LAEQAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKLAEQAER 9 1 P27348;E9PG15;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;P31946-2;P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1;P31947-2;P31947 P27348;P31946;P31946-2;P63104;P31947-2 YWHAQ;YWHAB;YWHAZ;SFN 14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma 1 37870300.0 12573000.0 16185000.0 9112300.0 True False 12173876.997112235 22647754.90366 6725515.266859655 1.0 1.860356804084046 0.552454675569255 23.537285358455765 -6.729316529067893 1.7262375172762703 1.518166111774835 0.5534012042118678 0.5558892858578088 0.36169203995353066 0.33750851066092785 1.9701246724449246 0.16608133896893568 0.4123577919909162 1.865019903371987e-07 6.729316529067893 -0.9647649075629673 AK(ub)LAEQAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKLAEQAER 9 1 P27348;E9PG15;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;P31946-2;P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1;P31947-2;P31947 P27348;P31946;P31946-2;P63104;P31947-2 YWHAQ;YWHAB;YWHAZ;SFN 14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma 1 10976900.0 5345600.0 2456400.0 3174900.0 True False 8109666.01570769 2018036.2280591994 2547379.6233918928 1.0 0.2488433215560845 0.3141164652721639 22.951211069783493 -10.07982077139307 5.502278847974573 1.0000062137844028 0.2814798935202044 0.9938486175359116 0.02664764933634735 2.031269310264055e-06 3.396684297257712e-07 0.025801698353344317 0.00860049184111757 8.321071017997619e-11 10.07982077139307 -0.7185263202641984 AK(ub)LAEQAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKLAEQAER 9 1 P27348;E9PG15;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;P31946-2;P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1;P31947-2;P31947 P27348;P31946;P31946-2;P63104;P31947-2 YWHAQ;YWHAB;YWHAZ;SFN 14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma 1 8333930.0 5345600.0 2203600.0 784730.0 True False 6919984.5775292935 2080967.722879921 641917.1920097539 1.0 0.30071854923452856 0.0927628067400901 22.722337391875943 -10.65367358433452 0.2568736744511631 1.8142753091279087 1.5554785375845776e-26 0.9991234737400442 0.011488993768240533 2.4163618430779614 0.13248965372176738 1.322686774853237 0.09060825246279886 2.2198642425756853e-11 10.65367358433452 -1.8142753091279087 AK(ub)LNWLSVDFNNWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKLNWLSVDFNNWK 14 1 Q15185-4;Q15185;A0A087WYT3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 89844000.0 15803000.0 20977000.0 53064000.0 True False 23974306.354053512 17233490.45595091 42575877.14122254 1.0 0.7188316609225741 1.7758960994516497 24.514985738723187 -6.835952389162312 1.301056749815477 0.8502614853802948 1.8079694670415725 0.9172688079103352 0.1285769881888537 0.1735799112629394 0.5725009331629167 0.07753956666665085 0.1784891892214179 1.4589741959391048e-07 6.835952389162312 0.9577079816612777 AK(ub)LNWLSVDFNNWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKLNWLSVDFNNWK 14 1 Q15185-4;Q15185;A0A087WYT3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 32711300.0 14909300.0 13121000.0 4681000.0 True False 12397743.543979842 13050314.568685431 5659775.4575014 1.0 1.0526362738824733 0.45651657799049267 23.563574230457522 -6.885379101013466 1.0493827063116714 1.0356677801768064 0.4096655931479759 0.9777700491435867 0.04017648618206613 0.12297029922991265 0.24441729533236514 0.029335591191313966 0.07201425864640695 1.3020297244336962e-07 6.885379101013466 -0.6260021870288305 down AK(ub)LNWLSVDFNNWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKLNWLSVDFNNWK 14 1 Q15185-4;Q15185;A0A087WYT3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 83784100.0 15803000.0 13510000.0 54471100.0 True False 20457295.023700856 12758156.623755531 44557918.720684156 1.0 0.6236482686970362 2.1780943506490695 24.286112060815636 -6.842742598397422 1.2695471523406927 0.7997985529666096 2.232074761235872 0.9290690965390304 0.17634646232384357 0.16562551562539932 0.5173493542493699 0.10886470796409672 0.25102552550631047 1.436340484463377e-07 6.842742598397422 1.4322762082692624 up AK(ub)LQIELGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKLQIELGK 9 1 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 8670400.0 3298600.0 3505400.0 1866400.0 True False 3193887.7485623537 4905124.500419512 1377533.8492001882 1.0 1.535784876167745 0.431303150782381 21.606882178429544 -6.774789155855533 1.5560505852654505 1.305426773263181 0.4239231634082872 0.7485658952507549 0.2261305633602218 0.25875404387441886 1.237040003775392 0.11450279398964255 0.2713926471360339 1.6796192528272586e-07 6.774789155855533 -0.8815036098548938 down AK(ub)LVILANNCPALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKLVILANNCPALR 14 1 P62888;E5RI99;E5RJH3 P62888 RPL30 60S ribosomal protein L30 1 12967400.0 3303100.0 6383600.0 3280700.0 True False 4330396.087265903 5431191.763077912 2941244.6346965497 1.0 1.2542020761216377 0.6792091474832209 22.04606755894128 -6.786527513645135 1.5101734473274264 1.142717162903798 0.6736647469291605 0.789881736273279 0.10784186065555207 0.24056600102803127 1.0838874736101476 0.05622006193871197 0.13196584352625107 1.634829577293292e-07 6.786527513645135 -0.46905241597463754 AK(ub)LVILANNCPALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKLVILANNCPALR 14 1 P62888;E5RI99;E5RJH3 P62888 RPL30 60S ribosomal protein L30 1 14328700.0 5802500.0 5243000.0 3283200.0 True False 5618302.813627921 7336557.241883805 2423231.4261112614 1.0 1.3058315803284999 0.431310220629867 22.421702953835837 -6.812196836299107 1.4050586627535513 1.1662465989067468 0.41519488862852677 0.865555784080204 0.13286441657676368 0.20380656513490755 0.7925415775009781 0.07434217417874256 0.17182178250302757 1.5410018627878408e-07 6.812196836299107 -0.7510517102782199 down AK(ub)LVILANNCPALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKLVILANNCPALR 14 1 P62888;E5RI99;E5RJH3 P62888 RPL30 60S ribosomal protein L30 1 29632700.0 8378800.0 14826000.0 6427900.0 True False 12711252.172330812 12180184.463933297 5157422.747551352 1.0 0.9582206614110358 0.4057367974162105 23.59960281995415 -6.9220409928057505 0.8094482238816498 1.0113169330282468 0.31232346651092646 0.9947292500707422 0.019662129462963848 0.09698584617374532 0.09950125171223412 0.01712662436283204 0.05234735569008266 1.1966275769894151e-07 6.9220409928057505 -0.6989934665173203 down AK(ub)LVILANNCPALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKLVILANNCPALR 14 1 P62888;E5RI99;E5RJH3 P62888 RPL30 60S ribosomal protein L30 1 13870300.0 3303100.0 5429300.0 5137900.0 True False 4524345.332921145 5189415.573705824 3924433.838372032 1.0 1.146998116157344 0.8674036903894382 22.109277620464173 -6.763786093520745 1.597744756521286 1.0849756959286463 0.8661675697832604 0.7064880990625861 0.06186680709610589 0.27656064337788655 1.3921675729683824 0.030536963571111395 0.07312737643213375 1.7227168693584908e-07 6.763786093520745 -0.21880812614538592 AK(ub)MQASIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKMQASIEK 9 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 7888100.0 2165700.0 0.0 5722400.0 True False 3285525.233877976 0.0 4591365.1317829825 1.0 0.0 1.397452402568735 21.647692591847292 -6.714616004134534 1.7787496203417459 0.388136284384086 1.394634765029164 0.4869666834058757 0.42110508038902894 0.36588630456745447 2.259353810946335 0.18819996759217242 0.47545948000973337 1.9292299519233492e-07 6.714616004134534 1.006498480645078 AK(ub)MQASIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKMQASIEK 9 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 7165900.0 2213900.0 3523900.0 1428100.0 True False 1840955.9423995058 3504916.051260619 1726709.1072116503 1.0 1.9038565619839354 0.9379415701611273 20.81202366997054 -6.661132214127299 1.968567237413281 1.5812768746942563 0.9419458958744138 0.24037023783154876 0.3847421145771556 0.4818892940253411 3.590977694321108 0.1578237385568491 0.4266395890141745 2.182065515174597e-07 6.661132214127299 -0.6393309788198425 AK(ub)MQASIEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKMQASIEK 9 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 9507000.0 2165700.0 3054800.0 4286500.0 True False 2803541.3423292353 2884797.6946149836 3506400.9832041753 1.0 1.0289834685363473 1.2507042183622628 21.41881891393974 -6.930937399656972 0.7390470981168076 0.9967430135283918 1.2973299098343158 0.9967195140344811 0.006413627179514344 0.09215362464035329 0.0753141320296166 0.00587608897574856 0.019959423736126494 1.1723643410333648e-07 6.930937399656972 0.30058689630592406 AK(ub)NNTVTPGGK(ub)PNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKNNTVTPGGKPNK 14 2 P18077;C9K025 P18077 RPL35A 60S ribosomal protein L35a 2 1989870.0 392760.0 871620.0 725490.0 True False 380292.04878595413 1219662.4114382532 535462.4047665257 1.0 3.2071730537935474 1.4080294512492124 18.536748249595185 -6.5954908021103655 2.2074626987038983 2.4886628024878297 1.413554248600672 0.007863361400963775 0.9551002950827497 0.6536514684836462 6.012623211308433 0.36002359600600253 1.063549176269463 2.538102739678465e-07 6.5954908021103655 -1.0751085538871576 AK(ub)NNTVTPGGK(ub)PNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKNNTVTPGGKPNK 14 2 P18077;C9K025 P18077 RPL35A 60S ribosomal protein L35a 2 5101940.0 725040.0 1350500.0 3026400.0 True False 993106.8814692701 1290830.4444937133 2311626.6506644962 1.0 1.2997900513829597 2.327671566674191 19.921589468190223 -6.948416004889148 0.5759699187035422 0.9875187073976924 2.690432928933803 0.9990710536889947 0.017328274326297976 0.0841280734653831 0.038643116762612936 0.01823565757214696 0.08577245173183971 1.1261182457363107e-07 6.948416004889148 1.7029142215361106 up AK(ub)NNTVTPGGK(ub)PNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKNNTVTPGGKPNK 14 2 P18077;C9K025 P18077 RPL35A 60S ribosomal protein L35a 2 2434900.0 392760.0 1101900.0 940240.0 True False 326597.3422181803 1095963.8459899737 1136839.8368214287 1.0 3.3557035049532806 3.4808606496925303 18.31715352502946 -10.347015900913721 0.5999100797809518 2.9420148534806434e-15 3.4663538710410267 0.9997643923520592 0.017515847622248278 1.683005202580396 0.290540892074292 2.7695502619121735 0.02172226875590374 4.497633873118688e-11 10.347015900913721 3.4663538710410235 AK(ub)PSPAPPSTTTAPDASGPQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKPSPAPPSTTTAPDASGPQK 21 1 Q5QNY5;P40855;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 7423910.0 905010.0 2017100.0 4501800.0 True False 876280.9529274277 2822538.549037541 3322643.52889488 1.0 3.221042908222723 3.791755963421079 19.741033974868152 -9.739592279761839 0.3636552038974038 2.0128525914813323e-13 3.9021214386530936 0.9986148068863172 0.04482117002406121 1.0799004879151546 0.15563798403760482 1.4193961144456058 0.16062939669355372 1.8214100151217905e-10 9.739592279761839 3.9021214386528924 AK(ub)PSPAPPSTTTAPDASGPQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKPSPAPPSTTTAPDASGPQK 21 1 Q5QNY5;P40855;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 5916010.0 905010.0 2638700.0 2372300.0 True False 752555.913740899 2624484.7993590557 2868336.961724111 1.0 3.4874283112239977 3.811460264083001 19.52143925030243 -10.054456088404446 0.4729639509536407 1.6154853906772882e-18 3.8120199501744976 0.9991789181036921 0.03598854008743407 1.357401750805956 0.21599771965907874 1.9762890371948496 0.06917768381935419 8.82152992280121e-11 10.054456088404446 3.8120199501744976 AK(ub)PTSDKPGSPYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKPTSDKPGSPYR 13 2 O60488-2;O60488;D6RDA8;D6RF95 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 2212510.0 505070.0 787420.0 920020.0 True False 662151.6611048381 669940.0053391196 824825.1558550074 1.0 1.0117621757850552 1.245674071826293 19.33680216830399 -6.9173453365976005 0.8441906728006046 0.9943287040742086 1.28118254479192 0.9934109459807433 0.009184027152734043 0.09975902610346718 0.11389724161498274 0.0078036885930204605 0.02281379708321946 1.2096358886067898e-07 6.9173453365976005 0.2868538407177115 AK(ub)PTSDKPGSPYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKPTSDKPGSPYR 13 2 O60488-2;O60488;D6RDA8;D6RF95 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 3303190.0 858190.0 1124800.0 1320200.0 True False 830947.2281994562 1573938.5057545127 974400.0148489553 1.0 1.8941497755098267 1.1726376619130685 19.664397331658137 -10.257390493979125 4.803985953974913 0.9998556016399641 1.5333937187123527 0.4215297917988583 0.2945560869279612 0.00045566946103096825 7.043802973080504e-05 0.28527916743437837 0.09506756826589192 5.5285279050581816e-11 10.257390493979125 0.5335381170723886 AK(ub)PTSDKPGSPYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKPTSDKPGSPYR 13 2 O60488-2;O60488;D6RDA8;D6RF95 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 2871620.0 858190.0 1519300.0 494130.0 True False 713623.0092632155 1511115.2293425621 597450.2984010178 1.0 2.117525934180181 0.8372071677143077 19.444802607092413 -6.6760039716258195 1.9158259654066099 1.7095743344023429 0.8421859869995297 0.3060716545873903 0.47405004073262047 0.4474452960655975 3.1715637057578183 0.19879181490045317 0.5270494584125646 2.1086088666035216e-07 6.6760039716258195 -0.8673883474028131 AK(ub)PTSDKPGSPYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKPTSDKPGSPYR 13 2 O60488-2;O60488;D6RDA8;D6RF95 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 2216340.0 1069200.0 581570.0 565570.0 True False 1384100.477082892 549205.1182588836 462642.0632382557 1.0 0.3967957004222551 0.3342546808547546 20.400517246784048 -13.999999999999998 0.32023594823537155 7.193579859104717 0.32187104389323584 0.999694232905012 0.005249040235989798 18.031688118729864 0.18047982571253668 74.8332762312078 0.020802964979122235 1.0000000000000041e-14 13.999999999999998 -6.871708815211481 AK(ub)QDVIEVIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKQDVIEVIEK 11 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 42513200.0 0.0 2171200.0 40342000.0 True False 0.0 1783732.3963369709 32368386.01747327 0.0 AK(ub)QDVIEVIEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKQDVIEVIEK 11 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 49452000.0 0.0 0.0 49452000.0 True False 0.0 0.0 40452243.42036919 0.0 AK(ub)QFLPFLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKQFLPFLQR 10 1 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 12776400.0 4744100.0 5018200.0 3014100.0 True False 4593501.142289046 7021993.429567291 2224616.7889382155 1.0 1.5286800225041572 0.4842965572508029 22.131162756770475 -6.769083964803012 1.5777720051732353 1.3036035787792986 0.4786041309526126 0.7270435669697453 0.22276256174443138 0.2679505746719796 1.3162319256219879 0.11129166382840608 0.2651638854079195 1.7018294515112833e-07 6.769083964803012 -0.824999447826686 down AK(ub)QFLPFLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKQFLPFLQR 10 1 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 19886300.0 5669600.0 5164900.0 9051800.0 True False 8601197.703280512 4243183.241452113 7262707.762455125 1.0 0.4933246959122629 0.8443833071858254 23.036106136147346 -10.099229791040287 5.850181348364424 1.000001779714897 0.6688540015490271 0.5426199262018155 0.14331907790512052 3.3267953358223455e-06 5.121692324360659e-07 0.1387688468792268 0.046256033493350925 7.957382032446115e-11 10.099229791040287 -0.33114777816586993 AK(ub)QFLPFLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKQFLPFLQR 10 1 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 10014800.0 3685300.0 4444300.0 1885200.0 True False 5047855.001487781 4247936.130665248 1439954.5869127403 1.0 0.8415329143593133 0.28526068725990245 22.26723903914564 -6.947876485817254 0.581689754630452 1.0066081212071174 0.09259138688816751 0.9990239296076808 0.009575271587559222 0.0843498141592538 0.03957892999668015 0.010014136940582093 0.04649020759618335 1.127518078882412e-07 6.947876485817254 -0.9140167343189499 down AK(ub)QFLPFLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKQFLPFLQR 10 1 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 14982600.0 4744100.0 7831000.0 2407500.0 True False 3944929.3492648685 7788812.848668207 2910897.1189777004 1.0 1.9743858911236625 0.7378832068361735 21.91156803220475 -6.696617047518924 1.8432278269475093 1.6070446938385974 0.7418103889351213 0.4014995121915541 0.41155853022531286 0.40254806416896566 2.65655026516798 0.17830459516223784 0.4604268368614825 2.0108651731254497e-07 6.696617047518924 -0.8652343049034761 AK(ub)QFLPFLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKQFLPFLQR 10 1 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 17067000.0 5669600.0 6177300.0 5220100.0 True False 7339408.964524108 5833527.824716882 4270095.362749117 1.0 0.7948225603606396 0.5818037097250096 22.807232458239795 -6.9706540430337345 0.24205911348880677 1.074562233251727 0.2958870568341288 0.9999870419895303 0.0006145822296035265 0.0760910735933497 0.0082672820563249 0.005018592693076186 0.020691814760460628 1.0699068226539508e-07 6.9706540430337345 -0.7786751764175983 AK(ub)QGYVIYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKQGYVIYR 9 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 25858460.0 1855560.0 2393900.0 21609000.0 True False 1796656.2634821914 3349796.7540235813 15948954.643895663 1.0 1.8644616792369448 8.877020589895242 20.7768829879633 -6.929837748924541 0.7481225619113161 0.8927165010864601 10.310733351608777 0.9965062692084351 0.20848543415971155 0.09272214107865902 0.07809346525708279 0.1897573174330523 0.6350825975673657 1.1753365750360575e-07 6.929837748924541 9.418016850522317 AK(ub)QGYVIYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKQGYVIYR 9 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 34113150.0 1889450.0 5946700.0 26277000.0 True False 2866433.7872977564 4885464.923220836 21083339.432381738 1.0 1.7043704078810973 7.355250808795907 21.45082552345561 -6.93004305405905 0.7464364665424433 0.9142045358562434 8.516628489440112 0.9965467320497704 0.16715241681519313 0.0926154945319808 0.07757012583460222 0.15232286371243478 0.5111863188320709 1.1747810864980576e-07 6.93004305405905 7.602423953583869 up AK(ub)QGYVIYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKQGYVIYR 9 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 15692860.0 1855560.0 2245900.0 11591400.0 True False 1542980.3552458675 2233800.890923753 14015108.147421863 1.0 1.4477182961722193 9.083141013281802 20.557288263397577 -6.918935167715809 0.8325849624722902 0.8249753844069633 10.284765869082225 0.9938799812582518 0.29018894208369483 0.09880250751611487 0.10889042162968242 0.24862749578915777 0.7373438489325793 1.205215843795471e-07 6.918935167715809 9.459790484675262 up AK(ub)QGYVIYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKQGYVIYR 9 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 38000450.0 1889450.0 6842000.0 29269000.0 True False 2445930.271627641 6461236.685398626 23942342.32530104 1.0 2.641627506862248 9.788644673573888 21.22195184554806 -6.942933418940356 0.6316836243529983 0.9220277551083691 11.894543255616302 0.9985234371147782 0.14661059160350084 0.08645350172965878 0.04870416258316844 0.1461127353568448 0.607628160128565 1.1404246110095308e-07 6.942933418940356 10.972515500507933 AK(ub)QLSSVQEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKQLSSVQEDR 11 1 A0A0A6YYG7;Q6IBW4-2;Q6IBW4;Q6IBW4-4;E5RJN3;Q6IBW4-5 A0A0A6YYG7 NCAPH2 Condensin-2 complex subunit H2 1 2286240.0 499320.0 573820.0 1213100.0 True False 483469.35991394985 802949.3184317687 895352.7177800841 1.0 1.6608070438521303 1.8519327014631148 18.883064935595183 -11.083918445223544 0.23547939549808994 5.7289825398112373e-11 1.9575623802620477 0.9992686490130751 0.009870708895860262 3.152183452695585 0.1279925601652919 1.784282008241831 0.09497409032838197 8.242928918147714e-12 11.083918445223544 1.957562380204758 AK(ub)QLSSVQEDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKQLSSVQEDR 11 1 A0A0A6YYG7;Q6IBW4-2;Q6IBW4;Q6IBW4-4;E5RJN3;Q6IBW4-5 A0A0A6YYG7 NCAPH2 Condensin-2 complex subunit H2 1 12215240.0 787840.0 2686300.0 8741100.0 True False 1195210.8788190559 2206908.7768423017 7013417.753639767 1.0 1.8464597469384378 5.867933331203836 20.188833754045618 -6.940951229346698 0.6506533310443781 0.9554964335163438 6.983434733901758 0.9982858650841735 0.08791982115557627 0.08733532900867584 0.05265336266800954 0.08621327564942347 0.3446953018076602 1.1456415881446792e-07 6.940951229346698 6.027938300385414 AK(ub)QLSSVQEDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKQLSSVQEDR 11 1 A0A0A6YYG7;Q6IBW4-2;Q6IBW4;Q6IBW4-4;E5RJN3;Q6IBW4-5 A0A0A6YYG7 NCAPH2 Condensin-2 complex subunit H2 1 2485660.0 499320.0 1056800.0 929540.0 True False 415206.70362659654 1051106.8086416249 1123902.516292639 1.0 2.5315265853388187 2.706850603509009 18.66347021102946 -10.472908548361408 0.44166183514417084 1.0549199788011273e-19 2.7120401318951552 0.9994092141810663 0.01863405067746976 1.9005052698818339 0.20837716456808217 2.2093542065614695 0.04018526417534423 3.3658243782100636e-11 10.472908548361408 2.7120401318951552 AK(ub)QLSSVQEDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKQLSSVQEDR 11 1 A0A0A6YYG7;Q6IBW4-2;Q6IBW4;Q6IBW4-4;E5RJN3;Q6IBW4-5 A0A0A6YYG7 NCAPH2 Condensin-2 complex subunit H2 1 9036640.0 787840.0 1941700.0 6307100.0 True False 1019874.4106481363 1833642.6881085227 5159272.516310981 1.0 1.7979102808778502 5.058733175815473 19.959960076138067 -6.944382081565625 0.6174506225206499 0.9642401709084492 6.064402178431027 0.998683369945356 0.0637069598736557 0.08582312861833818 0.045924459482962074 0.06430783922623175 0.27570172491239386 1.1366268695523556e-07 6.944382081565625 5.100162007522577 AK(ub)QLVALLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKQLVALLR 9 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 16401400.0 6399300.0 8966300.0 1035800.0 True False 8389544.270909354 7628562.990363667 928625.35209519 1.0 0.9092940860703983 0.11068841430579102 23.000161013367556 -6.985451980507178 0.809124138982343 1.0091138091388214 2.0012600944954813e-22 0.9959808605340408 0.025331130187190704 0.08273274393158626 0.08824506944517921 0.02285783625879176 0.06305397948604914 1.0340654302094422e-07 6.985451980507178 -1.0091138091388214 down AK(ub)QLVALLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKQLVALLR 9 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 32346300.0 12571000.0 17259000.0 2516300.0 True False 12171940.486017508 24150608.704496026 1857205.5426181084 1.0 1.9841214909191338 0.1525808924839527 23.537055849221925 -6.760769491752372 1.609617772121987 1.5710986463947274 0.14565429115700912 0.6940483127703747 0.413971274343237 0.2816467898331505 1.4383672491227633 0.20290569870808747 0.4872359723520567 1.7347244842405872e-07 6.760769491752372 -1.4254443552377183 AK(ub)QLVALLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKQLVALLR 9 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 34501100.0 17615000.0 8636300.0 8249800.0 True False 26723242.828997843 7095084.789280112 6619223.413984203 1.0 0.26550238811515475 0.24769536602801706 24.67159175171821 AK(ub)QLVALLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKQLVALLR 9 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 20769500.0 6399300.0 12219000.0 2151200.0 True False 8765294.144580022 11679124.177170457 1643130.8653547002 1.0 1.3324280947710339 0.1874587250869068 23.063371074890448 -6.829036951074454 1.3323468052054837 1.1777461084231202 0.15728007966706656 0.9039064483775299 0.14908486037134028 0.1820049419993301 0.6322328533391143 0.08786842836635528 0.20220445295059494 1.4823919534356916e-07 6.829036951074454 -1.0204660287560536 down AK(ub)QLVALLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKQLVALLR 9 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 41119900.0 12571000.0 24495000.0 4053900.0 True False 10453343.489725914 24363040.5731232 4901551.746884189 1.0 2.3306457495698343 0.4688979895955478 23.3174611246562 -6.714809869569237 1.7778859874870803 1.8139912677778685 0.4725873609226884 0.4879909911366418 0.5603244410430355 0.3654884838204632 2.254782649335936 0.2505217775692298 0.6327999479095495 1.9283689519485017e-07 6.714809869569237 -1.34140390685518 AK(ub)QPYREDTEWLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKQPYREDTEWLK 13 2 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 35196800.0 5700800.0 12239000.0 17257000.0 True False 8648530.384306038 10054854.82625654 13846146.385988189 1.0 1.1626084871601392 1.6009825682192143 23.04402357058182 -6.953825905173668 0.5151354993468167 0.9922608301057064 1.7907314501799263 0.9994683152928651 0.005852511194005912 0.0819849187796609 0.02987897194671339 0.0066826954578366946 0.036193940020452335 1.112177474461448e-07 6.953825905173668 0.7984706200742199 AK(ub)QPYREDTEWLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKQPYREDTEWLK 13 2 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 34238800.0 5700800.0 12791000.0 15747000.0 True False 7379797.979568047 12079169.605807338 12881207.57786447 1.0 1.6367886545472012 1.7454688615498428 22.81514989267427 -11.361189559127398 0.31095060795623836 3.139861834780284e-09 1.7729926788623978 0.9993692622809335 0.00825785536863598 3.591987632708898 0.16291975726956048 2.485101701135869 0.037427110403217924 4.3532182467478454e-12 11.361189559127398 1.7729926757225358 AK(ub)TDAGGEDAILQTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKTDAGGEDAILQTR 15 1 Q9NT62;Q9NT62-2 Q9NT62 ATG3 Ubiquitin-like-conjugating enzyme ATG3 1 8895200.0 2328900.0 2501300.0 4065000.0 True False 2254970.3442754108 3500082.134107186 3000254.5526139983 1.0 1.5521632659128681 1.330507321406956 21.1046770296571 -10.096051248873469 4.440238637247982 0.9999618778765468 1.4413352936382948 0.8409132809349856 0.09049066054414356 62964692.876784295 2.1005361463967027 27525.523986134358 0.030977359995206073 8.015834670358508e-11 10.096051248873469 0.44137341576174804 AK(ub)TDAGGEDAILQTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKTDAGGEDAILQTR 15 1 Q9NT62;Q9NT62-2 Q9NT62 ATG3 Ubiquitin-like-conjugating enzyme ATG3 1 15432000.0 0.0 0.0 15432000.0 True False 0.0 0.0 12381858.435914133 0.0 AK(ub)TDAGGEDAILQTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKTDAGGEDAILQTR 15 1 Q9NT62;Q9NT62-2 Q9NT62 ATG3 Ubiquitin-like-conjugating enzyme ATG3 1 5287600.0 2277900.0 1746100.0 1263600.0 True False 3120101.187932874 1668951.5284194555 965163.7046588877 1.0 0.53490301368244 0.3093373088000158 21.573161387181486 -10.528727592873347 0.15145678460573578 1.8477987801620637 1.6894336830783037e-20 0.99968237909135 0.00512484548735414 2.35200323668242 0.07963275052320899 0.9379059660296741 0.20097093341868338 2.9598684340417246e-11 10.528727592873347 -1.8477987801620637 AK(ub)TDAGGEDAILQTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKTDAGGEDAILQTR 15 1 Q9NT62;Q9NT62-2 Q9NT62 ATG3 Ubiquitin-like-conjugating enzyme ATG3 1 7525000.0 2328900.0 2904600.0 2291500.0 True False 1936583.53776332 2888952.3432820425 2770642.055301099 1.0 1.4917778071266021 1.4306855352602474 20.885082305091377 -10.54026103832543 6.1514222326078745 0.9993147159543376 1.4612316711934235 0.9870127158198473 0.024940815549992855 0.00023472661295294975 1.7542774553471097e-05 0.024182432149422884 0.008049613605496102 2.8822985394860344e-11 10.54026103832543 0.4619169552390858 AK(ub)TDAGGEDAILQTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKTDAGGEDAILQTR 15 1 Q9NT62;Q9NT62-2 Q9NT62 ATG3 Ubiquitin-like-conjugating enzyme ATG3 1 17810900.0 0.0 6068900.0 11742000.0 True False 0.0 5731160.380008138 9605076.483094232 0.0 AK(ub)TGGAYGEDLGADYNLSQVCDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKTGGAYGEDLGADYNLSQVCDGK 24 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 46136000.0 19485000.0 16447000.0 10204000.0 True False 18866459.340549745 23014372.869971935 7531266.286561674 1.0 1.2198564900043043 0.3991881121210008 24.16932036266039 -6.835401126213466 1.3034997567715694 1.1171152849550825 0.3745488131912937 0.9162688783994483 0.10036863192465079 0.1742383294527873 0.5770415710284704 0.06041813378391232 0.13907285764487592 1.460827291279761e-07 6.835401126213466 -0.7425664717637888 down AK(ub)TGGAYGEDLGADYNLSQVCDGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKTGGAYGEDLGADYNLSQVCDGK 24 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 111114000.0 37227000.0 31418000.0 42469000.0 True False 56476080.65825161 25811212.430045597 34074983.53517607 1.0 0.4570291020411731 0.6033524837067007 25.75113663576853 -10.455504878923001 9.20831747830254 1.0000045502743604 0.5301907928740043 0.9321817941883053 0.059736270419843 5.580380944878676e-06 3.299370594119548e-07 0.05783995480625227 0.019279798375049555 3.503443524635805e-11 10.455504878923001 -0.46981375740035614 AK(ub)TGGAYGEDLGADYNLSQVCDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKTGGAYGEDLGADYNLSQVCDGK 24 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 58826000.0 19883000.0 27067000.0 11876000.0 True False 27234282.417871445 25871090.441400506 9071133.393897556 1.0 0.9499457354684551 0.33307774571453275 24.698920519059552 -6.9230135651089535 0.802064471773929 1.012190037437205 0.22636578271604182 0.9949777637593434 0.021492870738348754 0.09643109321824465 0.09666457029290555 0.018820163396771124 0.05810679548854953 1.1939508110459702e-07 6.9230135651089535 -0.7858242547211632 down AK(ub)TGGAYGEDLGADYNLSQVCDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKTGGAYGEDLGADYNLSQVCDGK 24 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 42473600.0 19485000.0 14475000.0 8513600.0 True False 16202640.831859771 14397020.301937474 10293754.397561168 1.0 0.8885601088946039 0.6353133729484536 23.949725638094666 -6.957472549501429 0.46970489375192503 1.0067081645964342 0.5067886772025162 0.9996646530900573 0.0027942667779721204 0.08061671311625701 0.02456367590776933 0.0034996094564209144 0.02090227507298383 1.1028779413725611e-07 6.957472549501429 -0.499919487393918 AK(ub)TGGAYGEDLGADYNLSQVCDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKTGGAYGEDLGADYNLSQVCDGK 24 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 121334000.0 37227000.0 27472000.0 56635000.0 True False 48191085.35387659 25943159.050171137 46328011.12417319 1.0 0.5383393808142197 0.961339857444121 25.522262957860978 -10.44267298288474 8.82465583678896 1.0000030199476515 0.7498396191291704 0.31802563660711247 0.17268922144955642 1.0260500699223256e-05 6.479871416617017e-07 0.1672076397268898 0.05573520656197143 3.608502554826997e-11 10.44267298288474 -0.2501634008184811 AK(ub)TVEQTATTTNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKTVEQTATTTNK 13 1 P08579 P08579 SNRPB2 U2 small nuclear ribonucleoprotein B 1 3747640.0 813720.0 2003710.0 930210.0 True False 787888.9040078084 2803801.852209613 686560.0952981719 1.0 3.5586258899539294 0.8713920094645319 19.58763269176261 -6.6572789220614235 1.9825888437028967 2.6506295736441237 0.8826468061735467 0.2241055822686987 1.0901165356797786 0.49091370861869005 3.706486447558231 0.4446813678558339 1.2080860155152062 2.201512105867238e-07 6.6572789220614235 -1.7679827674705768 AK(ub)TVEQTATTTNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKTVEQTATTTNK 13 1 P08579 P08579 SNRPB2 U2 small nuclear ribonucleoprotein B 1 4592620.0 1626460.0 978500.0 1987660.0 True False 2467458.7301533823 803879.0299446051 1594798.1297776734 1.0 0.32579228990575027 0.6463322406525265 21.234594524197956 -10.54988293429638 6.431371774427497 1.0006546969450127 0.48606226527944757 0.7741461321984358 0.13085988691774225 0.0012298843499165418 8.607647935823131e-05 0.12685397642048085 0.042234846893250126 2.8191427393357208e-11 10.54988293429638 -0.5145924316655652 AK(ub)TVEQTATTTNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKTVEQTATTTNK 13 1 P08579 P08579 SNRPB2 U2 small nuclear ribonucleoprotein B 1 5072310.0 813720.0 3662510.0 596080.0 True False 676644.2339081827 3642779.3316786843 720717.5720374781 1.0 5.383596207771707 1.0651351713658082 19.368037967196887 -6.642698300931166 2.0346200502988068 3.8607265697599806 1.0831404487304388 0.1650580267484545 1.8743484210563892 0.5266052910047556 4.169635289838605 0.7493249840177992 2.0757066223021488 2.2766784622500882e-07 6.642698300931166 -2.777586121029542 AK(ub)TVEQTATTTNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKTVEQTATTTNK 13 1 P08579 P08579 SNRPB2 U2 small nuclear ribonucleoprotein B 1 4931130.0 1626460.0 1175850.0 2128820.0 True False 2105484.5323197185 1110412.913844779 1741396.6035377833 1.0 0.5273906774424892 0.8270764172364633 21.005720846290405 -10.411775745023265 6.421243076517669 1.0000539209412231 0.6772335473394772 0.6073225023174428 0.12234619094728803 9.445857714047095e-05 8.653072786492938e-06 0.11848090536506403 0.039487063334229903 3.874576633040761e-11 10.411775745023265 -0.322820373601746 AK(ub)VDEFPLCGHMVSDEYEQLSSEALEAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKVDEFPLCGHMVSDEYEQLSSEALEAAR 29 1 P27635;X1WI28;A6QRI9;B8A6G2 P27635 RPL10 60S ribosomal protein L10 1 189658000.0 17977000.0 59575000.0 112106000.0 True False 27272423.29474278 48943375.78840047 89948199.96219462 1.0 1.7946104480504719 3.2981374258566034 24.700939561017016 -6.961114297853937 0.4194342494730376 0.9331352778229139 4.216276829176952 0.9998093195086316 0.013159340819633538 0.07930544708190485 0.019678138014057784 0.019442518434189246 0.1251768241338241 1.0936684961333186e-07 6.961114297853937 3.2831415513540376 AK(ub)VDEFPLCGHMVSDEYEQLSSEALEAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKVDEFPLCGHMVSDEYEQLSSEALEAAR 29 1 P27635;X1WI28;A6QRI9;B8A6G2 P27635 RPL10 60S ribosomal protein L10 1 291800000.0 17977000.0 41223000.0 232600000.0 True False 23271580.87964756 38928903.81207071 190269186.6775433 1.0 1.6728087366903575 8.176031858838842 24.472065883109465 -6.9267567843830244 0.7729515709618624 0.8883105655368019 9.40714415389152 0.9958615249362545 0.20816925676127487 0.09435707063379331 0.08618945025697611 0.18611389003268525 0.5992648148378148 1.1837042737150003e-07 6.9267567843830244 8.518833588354719 up AK(ub)VIQPGYGVQYDYLDPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKVIQPGYGVQYDYLDPR 18 1 Q9Y2Z2-2;Q9Y2Z2-4;Q9Y2Z2-6;H7C2S9 Q9Y2Z2-2 MTO1 Protein MTO1 homolog, mitochondrial 1 11277300.0 2707900.0 3274200.0 5295200.0 True False 3550083.1233409 2785702.122731641 4747303.499145049 1.0 0.7846864498513719 1.3372372798633156 21.759421374287335 -6.801041181519202 1.4518092425278262 0.8813592639607666 1.3450492852113718 0.835151630127086 0.09232830908920038 0.21927360726288922 0.9123580843773569 0.05002938907141748 0.1162690118638792 1.5810981061905933e-07 6.801041181519202 0.4636900212506052 AK(ub)VIQPGYGVQYDYLDPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKVIQPGYGVQYDYLDPR 18 1 Q9Y2Z2-2;Q9Y2Z2-4;Q9Y2Z2-6;H7C2S9 Q9Y2Z2-2 MTO1 Protein MTO1 homolog, mitochondrial 1 16363400.0 4541700.0 4558600.0 7263100.0 True False 4397526.219500888 6378872.752784957 5360676.221670529 1.0 1.4505593450467131 1.2190208662994524 22.068260748870447 -10.035223107350955 4.182283406157163 0.999970367722557 1.3347901055782294 0.7359837679549626 0.09452518854854315 27977478.055023253 38159326.96129892 10823.78695770714 0.034592679001799846 9.220976021021728e-11 10.035223107350955 0.33481973785567243 AK(ub)VIQPGYGVQYDYLDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKVIQPGYGVQYDYLDPR 18 1 Q9Y2Z2-2;Q9Y2Z2-4;Q9Y2Z2-6;H7C2S9 Q9Y2Z2-2 MTO1 Protein MTO1 homolog, mitochondrial 1 11750600.0 2707900.0 3026100.0 6016600.0 True False 3709083.808245937 2892396.8960254933 4595602.995766599 1.0 0.7798143815448961 1.2390129836240895 21.822631435810226 -6.776317776797954 1.550216715437086 0.8747289388185785 1.2422392295716322 0.7541442716633582 0.09297940033716678 0.25633845117027876 1.2164826221669076 0.047253131376348796 0.11184566730413847 1.673717754997246e-07 6.776317776797954 0.36751029075305375 AK(ub)VIQPGYGVQYDYLDPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKVIQPGYGVQYDYLDPR 18 1 Q9Y2Z2-2;Q9Y2Z2-4;Q9Y2Z2-6;H7C2S9 Q9Y2Z2-2 MTO1 Protein MTO1 homolog, mitochondrial 1 14694100.0 4541700.0 6335900.0 3816500.0 True False 3776624.78142456 6301767.249122318 4614512.50449777 1.0 1.6686241323516557 1.221861522276289 21.848666024304723 -10.266063349497099 4.332240859822362 0.9997055534549658 1.445242827322193 0.5697587521527894 0.18239007183415443 0.0005190452535275315 8.793300655945849e-05 0.1767136514562336 0.058866142556742974 5.419218357942803e-11 10.266063349497099 0.4455372738672271 AK(ub)YLLADCNEAFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKYLLADCNEAFIK 14 1 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7 O60216 RAD21 Double-strand-break repair protein rad21 homolog 1 6378300.0 1782000.0 0.0 4596300.0 True False 1725431.3854174844 0.0 3392391.14395565 1.0 0.0 1.966111879398107 20.718525673125914 -6.768424992952902 1.5804223565768547 0.42528666823441835 1.97653851731421 0.724553281523682 0.42128200235470237 0.2689670845486665 1.3255874591181718 0.21014010244663806 0.5009591787815718 1.704413663365469e-07 6.768424992952902 1.5512518490797917 AK(ub)YLLADCNEAFIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKYLLADCNEAFIK 14 1 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7 O60216 RAD21 Double-strand-break repair protein rad21 homolog 1 64836900.0 7897200.0 17859000.0 39080700.0 True False 11980629.762654655 14671921.916996108 31356382.51532072 1.0 1.2246369521183769 2.6172566164312223 23.514200409698773 -6.935147488952047 0.7032633817713808 0.9823147718439031 2.9446258747222767 0.9974566357568553 0.03607574397305549 0.09005177472184565 0.06522441126020131 0.03393885196025528 0.12263849538454481 1.1610542460508452e-07 6.935147488952047 1.9623111028783735 up AK(ub)YLLADCNEAFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKYLLADCNEAFIK 14 1 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7 O60216 RAD21 Double-strand-break repair protein rad21 homolog 1 10496000.0 1782000.0 1576200.0 7137800.0 True False 1481811.9559853296 1567708.6977487952 8630280.978541644 1.0 1.057967369892321 5.824140467811887 20.49893094856019 -6.909554962019748 0.8987636702365575 0.8503448748083284 6.434253545000715 0.9907524584801133 0.21738696440251573 0.10471294905192313 0.14037033626925632 0.1775869410940409 0.48871965984645366 1.2315301199152317e-07 6.909554962019748 5.583908670192386 up AK(ub)YLLADCNEAFIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKYLLADCNEAFIK 14 1 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7 O60216 RAD21 Double-strand-break repair protein rad21 homolog 1 46577700.0 7897200.0 17435000.0 21245500.0 True False 10223081.077084761 16464726.92340326 17379036.997238815 1.0 1.6105444923360015 1.699980354865254 23.285326731791223 -11.43559624906558 0.33129662873258153 1.2974465641239659e-12 1.7179023230295385 0.9994432614013418 0.0073391791539722424 3.752340991977619 0.17193560111353265 2.7299061043157073 0.028470926728272766 3.667783993942504e-12 11.43559624906558 1.717902323028241 AK(ub)YQYGGLNSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKYQYGGLNSGR 12 1 P62140 P62140 PPP1CB Serine/threonine-protein phosphatase PP1-beta catalytic subunit 1 2463800.0 457370.0 804130.0 1202300.0 True False 599616.4991773803 684156.9384741901 1077897.5292759656 1.0 1.140990849005642 1.7976448792765771 19.193680555777778 -6.941400850350755 0.6464069779935736 0.9927705494600948 1.9822634140248012 0.9983416071596157 0.01415465097522404 0.08713346355569052 0.05174413208512333 0.013929328590087501 0.056177302474749044 1.1444561299057257e-07 6.941400850350755 0.9894928645647064 AK(ub)YQYGGLNSGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKYQYGGLNSGR 12 1 P62140 P62140 PPP1CB Serine/threonine-protein phosphatase PP1-beta catalytic subunit 1 4245210.0 949820.0 705890.0 2589500.0 True False 919668.4840051824 987755.5581677194 1911232.2666651781 1.0 1.074034367108043 2.0781752336904136 19.810754376177865 -6.921703237576515 0.8119942695410364 0.9791751997613065 2.2466205641365997 0.9946411434519135 0.03599717169825122 0.09717985270739296 0.10049687662410964 0.03129834611089148 0.09533593485454732 1.1975585683826987e-07 6.921703237576515 1.2674453643752932 up AK(ub)YQYGGLNSGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKYQYGGLNSGR 12 1 P62140 P62140 PPP1CB Serine/threonine-protein phosphatase PP1-beta catalytic subunit 1 3593920.0 949820.0 1466000.0 1178100.0 True False 789817.4141604858 1458102.3670217842 1424435.2630810488 1.0 1.8461258778038376 1.8034994386583791 19.59115965161214 -10.097001575910284 5.093224231628091 0.9999792422022226 1.8248126582331288 0.9980008761105159 0.017402170916722637 4.1019550690814145e-06 7.272097096230718e-07 0.016850002335518265 0.005616526511351844 7.998313526797061e-11 10.097001575910284 0.8248334160309062 AKDPFAHLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKDPFAHLPK 10 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 23216600.0 733600.0 12102000.0 10381000.0 False True 961756.7041925057 10296428.77322653 9306873.70158348 1.0 10.705855990753344 9.676952248955274 19.87531245570065 -10.48779569388909 6.787645420334109 0.9969329514743536 10.191404119854308 0.9906892538431682 0.4200481936409339 0.01945732866267808 0.0014682730550175172 0.4059076629349327 0.13556997154798697 3.25240264897288e-11 10.48779569388909 9.194471168379955 AKDPFAHLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKDPFAHLPK 10 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 25843100.0 6759400.0 3093700.0 15990000.0 False True 6544826.546908499 4329030.543432374 11801739.310282364 1.0 0.6614431280042442 1.803216513943675 22.641923527234816 -6.827273264882021 1.3401167686234858 0.8187308122107356 1.832250028904822 0.9002967496658268 0.15119159229251192 0.1842009609168691 0.6479392415402688 0.08860704697161355 0.20393984313645455 1.488424243187959e-07 6.827273264882021 1.0135192166940863 AKDPFAHLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKDPFAHLPK 10 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 129688300.0 1237700.0 126890000.0 1560600.0 False True 1877681.3879903837 104245488.103905 1252146.7259647208 1.0 55.51819854564106 0.666857931262156 20.840520851185698 -6.228903465358372 20.954150884618564 9.999999999999998 0.6667097675297224 0.0 26.788719011556594 2972.2367039446226 2951453.3075262923 11.705149851399053 255.25389316372792 5.903322841930076e-07 6.228903465358372 -9.333290232470276 AKDPFAHLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKDPFAHLPK 10 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 27159600.0 733600.0 14265000.0 12161000.0 False True 1004831.7447945719 13634725.13195323 9288822.263656804 1.0 13.569162402149942 9.244156856883352 19.938522517223543 -10.069376549737573 8.10740034031513 0.9999997032611864 11.406659629516646 0.8853142744031873 1.7656761201018132 9.451942662316093e-06 1.10605784701145e-06 1.7096085519346402 0.5698695173292043 8.523607645291819e-11 10.069376549737573 10.40665992625546 AKDPFAHLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKDPFAHLPK 10 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 6605300.0 1237700.0 2275900.0 3091700.0 False True 1602227.048714456 2149244.1643231134 2529042.3235209025 1.0 1.3414104861402483 1.5784543929339323 20.611647173278147 -7.118895535236309 0.07133205168781716 6.522759568861002e-09 2.8917074464233194 0.9999999186260209 6.748327866385381e-05 0.07958194191502525 0.0024624934296702513 0.04025029056391481 0.05878661495191388 7.605091870659314e-08 7.118895535236309 2.89170743990056 AKFEELNMDLFR ddPTM_RPMI8226_Bortezomib_1h_R1 2 AKFEELNMDLFR 12 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 47737600.0 12106400.0 19971900.0 15659300.0 False True 15871607.638544356 16992170.36985644 14039025.850612268 1.0 1.0706017157701646 0.8845371036339352 23.919944930676294 -6.803922053556431 1.4401974779430902 1.0387625070308795 0.8817235860606575 0.843281221097284 0.030361004931241532 0.2152139577508542 0.8808832980727075 0.01658262318017221 0.03847056001011429 1.5706446757040584e-07 6.803922053556431 -0.15703892097022198 AKFEELNMDLFR ddPTM_RPMI8226_Bortezomib_2h_R1 2 AKFEELNMDLFR 12 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 75114600.0 29089300.0 12513600.0 33511700.0 False True 28165876.09417778 17510345.737561908 24733980.44054967 1.0 0.6216865287276295 0.8781541308300536 24.74744501123967 -9.947255834071408 5.3249754460050935 1.0000006197857023 0.7499203297775957 0.5590325080672095 0.10470246012204516 7.703419575426893e-07 1.5234263493113127e-07 0.10137797184962855 0.033792573696005385 1.1291305708022688e-10 9.947255834071408 -0.2500802900081066 AKFEELNMDLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AKFEELNMDLFR 12 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 89370400.0 12106400.0 32279200.0 44984800.0 False True 16582463.243158389 30852998.21096001 34360316.73103768 1.0 1.8605799246194241 2.072087616127483 23.983154992199186 -10.784004966739436 0.2790209180971896 3.2858337144840404e-14 2.151686215936103 0.9991699547361222 0.013357863106785982 2.5411657051643197 0.14153329029363085 1.7763349505290107 0.08342413341048968 1.644352917728044e-11 10.784004966739436 2.15168621593607 AKFEELNMDLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKFEELNMDLFR 12 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 37265300.0 25987900.0 4049800.0 7227600.0 False True 21610090.30917571 4027982.9235776346 8738857.743353365 1.0 0.18639361825652995 0.40438784004724027 24.36520176548474 -10.263250770214176 5.168766675334149 1.0001096133588938 0.2953907291517198 0.9330199519935521 0.08899576837763408 0.00011243162152823972 1.6025623067055425e-05 0.08618303855067184 0.028723260734042914 5.4544282068380847e-11 10.263250770214176 -0.704718884207174 AKFENLCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKFENLCK 8 1 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 43288550.0 924550.0 23801000.0 18563000.0 False True 1212094.0033549375 20249983.575571332 16642278.82886948 1.0 16.706611467032833 13.73018823854054 20.209070159979063 -9.854175507389847 8.149128159000972 0.999999993463604 15.218399852786687 0.9681796368912896 1.2151196947289147 1.5656230230626126e-07 0.0 1.1765345940992749 0.39217819511114316 1.399021834635094e-10 9.854175507389847 14.218399859323084 AKFENLCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKFENLCK 8 1 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 15522400.0 8132800.0 2246700.0 5142900.0 False True 7874628.715669648 3143819.0263857194 3795820.2063071434 1.0 0.39923393723057243 0.48203164153681016 22.908780472165073 -10.690641494288425 6.7754670693429615 1.0044838247874042 0.44063278938419176 0.9838331536599921 0.033802021237353985 0.002296555444675274 0.00010485741779771497 0.032830146918505165 0.01090955544336845 2.0387243296269227e-11 10.690641494288425 -0.5638510354032125 AKFENLCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKFENLCK 8 1 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 41690550.0 924550.0 22222000.0 18544000.0 False True 1266381.1200242946 21240158.561672952 14164289.125668274 1.0 16.772327244791423 11.184854939559225 20.272280221501955 -9.54601377299188 7.104612406085458 0.9999999984930404 13.978591092190442 0.8779576655562579 2.28107601668022 5.516243631804914e-08 0.0 2.2086423724400883 0.7362141186614739 2.84437090110139e-10 9.54601377299188 12.978591093697402 AKGEVDVDVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKGEVDVDVPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 4770670.0 811370.0 1880200.0 2079100.0 False True 1063713.9273182566 1599681.4889621984 1863974.6761354574 1.0 1.503864382969185 1.7523270385626601 20.020678777370335 -10.620785089790811 0.1416682108244123 1.421907575601257e-19 2.1335455650695976 0.99972220233179 0.0052165188388808344 2.5468261486572406 0.07714764476280928 1.1163708443946834 0.2481257123091214 2.3945003795000905e-11 10.620785089790811 2.1335455650695976 AKGEVDVDVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKGEVDVDVPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5248620.0 1547000.0 627320.0 3074300.0 False True 1497891.331784989 877812.147430583 2269048.602976927 1.0 0.5860319295556123 1.51482858257346 20.51450153305303 -6.785532479000499 1.514085811359578 0.7672855513715703 1.5235346862854886 0.7865542614905419 0.1755256732456501 0.24206897840074584 1.0963015847354585 0.09127380730329097 0.21441484487904522 1.6385795144479613e-07 6.785532479000499 0.7562491349139183 AKGEVDVDVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKGEVDVDVPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5133370.0 811370.0 1614200.0 2707800.0 False True 1111355.4154497976 1542879.3065544255 2068273.4088915288 1.0 1.3882861280070136 1.8610368745577568 20.083888838893227 -6.968492147564344 0.2919620957216579 0.9097688733876553 2.354200329547444 0.999968116760772 0.001988020816052538 0.07679505928197038 0.010772252021566696 0.0081731919622062 0.04277477276082087 1.0752460416345034e-07 6.968492147564344 1.4444314561597889 AKGEVDVDVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKGEVDVDVPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 2839740.0 1547000.0 882470.0 410270.0 False True 1286399.0437201494 877715.9589534205 496055.56012584857 1.0 0.6823045797788729 0.3856156163575035 20.294906808487305 -7.217435376898958 0.2324479675858221 1.131873564294791 2.516747897840317e-12 0.9999732730800961 0.0012969382437031467 0.09339773708695707 0.011990978285541461 0.013003069477810398 0.039732680702164104 6.061283858355487e-08 7.217435376898958 -1.1318735642922744 down AKGFFIDTRYSSFEGAEEWSGMLYI ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKGFFIDTRYSSFEGAEEWSGMLYI 25 2 Q8TF46-3 Q8TF46-3 DIS3L DIS3-like exonuclease 1 0 137374000.0 20695000.0 57702000.0 58977000.0 False True 27131345.410665076 49093086.520634316 52874625.78733153 1.0 1.8094600830718954 1.948839063710678 24.693457255110612 -11.02900783540432 0.3265421413310863 2.831316452146838e-25 1.9798452768764445 0.9993111726541619 0.010979105108712684 2.906319398233663 0.16519274452599136 2.2206066653974332 0.04510011809788029 9.353887980050965e-12 11.02900783540432 1.9798452768764445 AKGFFIDTRYSSFEGAEEWSGMLYI ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKGFFIDTRYSSFEGAEEWSGMLYI 25 2 Q8TF46-3 Q8TF46-3 DIS3L DIS3-like exonuclease 1 0 421920000.0 156170000.0 160200000.0 105550000.0 False True 236921307.55632097 131611058.35168697 84687996.2357915 1.0 0.5555053688887833 0.3574520042510717 27.819832712524992 -13.962627982196118 0.11081766962593054 3.1288003425529385 3.710031168508311e-21 0.9997446756246658 0.004293094118787528 11.79789590236763 0.10026174158469123 5.623625646357993 0.3153786853166555 1.089863273361736e-14 13.962627982196118 -3.1288003425529385 AKGFFIDTRYSSFEGAEEWSGMLYI ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKGFFIDTRYSSFEGAEEWSGMLYI 25 2 Q8TF46-3 Q8TF46-3 DIS3L DIS3-like exonuclease 1 0 188080000.0 20695000.0 93319000.0 74066000.0 False True 28346500.76134632 89195858.01533426 56573136.23715192 1.0 3.1466267659027234 1.99577142566732 24.756667316633504 -10.324620698632248 5.877989070447744 0.999831593418739 2.5711990957850257 0.7130716469851135 0.4698347252223248 0.0010370002118575714 0.00011915179901233053 0.4549618801370281 0.15163850552133137 4.735646773234935e-11 10.324620698632248 1.5713675023662868 AKLNWLSVDFNNWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKLNWLSVDFNNWK 14 1 Q15185-4;Q15185;A0A087WYT3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 3512560.0 865610.0 911250.0 1735700.0 False True 1134823.092579164 775295.0520246797 1556106.4140100605 1.0 0.6831858261384437 1.3712325949178799 20.114035982830604 -6.781507957212744 1.529886524076035 0.8209549028762162 1.3769509107234623 0.7726729468861648 0.13406647963243504 0.24826747840253177 1.1478227586554586 0.06901144901203986 0.16264142883777088 1.6538344826746397e-07 6.781507957212744 0.5559960078472461 AKLPLGLLLHPFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKLPLGLLLHPFK 13 1 O95486;O95486-2 O95486 SEC24A Protein transport protein Sec24A 0 4204400.0 1156400.0 1924500.0 1123500.0 False True 1516051.598593529 1637372.1016422457 1007250.9973729927 1.0 1.0800239933530416 0.6643909734387927 20.531887425582646 -6.856804042726329 1.2017346610887991 1.043101934241438 0.6454543210019831 0.9496404070594817 0.040406720998705146 0.15013130759955395 0.4138149753434981 0.026256248352100327 0.061087716197809214 1.3905799308840644e-07 6.856804042726329 -0.39764761323945497 AKLPLGLLLHPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKLPLGLLLHPFK 13 1 O95486;O95486-2 O95486 SEC24A Protein transport protein Sec24A 0 6041600.0 2994300.0 1014100.0 2033200.0 False True 2899247.585496953 1419035.4184616369 1500643.925307449 1.0 0.48944954737917057 0.5175977149430745 21.467247109041807 -10.702827754355122 6.743694671942972 1.0049188059216005 0.5035236311611379 0.9975949798486445 0.011491441287654136 0.0008532705232756085 3.760076434457666e-05 0.011171537184997873 0.0037088467275837333 1.9823130756099696e-11 10.702827754355122 -0.5013951747604627 AKLPLGLLLHPFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKLPLGLLLHPFK 13 1 O95486;O95486-2 O95486 SEC24A Protein transport protein Sec24A 0 6820800.0 1156400.0 1786600.0 3877800.0 False True 1583952.330534954 1707662.104503862 2961943.5057979063 1.0 1.0781019552066489 1.8699701049699886 20.595097487105537 -6.9259711093118295 0.7791470872257482 0.985991512770783 2.017028859659405 0.9956855619725226 0.025813609213506904 0.094784278362759 0.08832727556300479 0.02297646930440208 0.07330152028735346 1.1858476320030472e-07 6.9259711093118295 1.0310373468886218 AKLPLGLLLHPFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKLPLGLLLHPFK 13 1 O95486;O95486-2 O95486 SEC24A Protein transport protein Sec24A 0 6281200.0 2994300.0 0.0 3286900.0 False True 2489893.1199814086 0.0 3974175.5930915084 1.0 0.0 1.5961229665637948 21.247652384476083 -6.737325207191552 1.6965537079149038 0.40316941988369714 1.596513966568225 0.5928622395796259 0.42019134779238554 0.32266951760544466 1.822532571774985 0.19602184502566972 0.48242762556208924 1.8309428673445008e-07 6.737325207191552 1.193344546684528 AKLPLGLLLHPFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKLPLGLLLHPFK 13 1 O95486;O95486-2 O95486 SEC24A Protein transport protein Sec24A 0 16224600.0 3137400.0 8337500.0 4749700.0 False True 4061426.147399803 7873510.795748475 3885303.336037529 1.0 1.938607402916642 0.9566352298502262 21.95355498010897 -6.656419324609793 1.9855431213791148 1.6059473519243705 0.9607493212441047 0.22047838545801235 0.39998342338909115 0.49301966877392667 3.732521078046764 0.1629669399212194 0.44326081989304855 2.2058738657681685e-07 6.656419324609793 -0.6451980306802658 AKPPPGGGEQEPPPPPAPQDVEMK(ub)EEAATGGGSTGEADGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGK 40 2 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 55396900.0 32883000.0 19707000.0 2806900.0 True False 31839147.16424416 27576107.870647356 2071688.6848049753 1.0 0.8661069886198377 0.06506734222867354 24.924298356927462 -7.0912836255104 0.8253068514362714 0.9995966026602952 1.5473429783571974e-23 0.9951635128607386 0.02870864397716984 0.07961597808047571 0.09494948879922337 0.025585675341492288 0.05851119687533213 8.104316148984436e-08 7.0912836255104 -0.9995966026602952 down AKPPPGGGEQEPPPPPAPQDVEMK(ub)EEAATGGGSTGEADGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKPPPGGGEQEPPPPPAPQDVEMKEEAATGGGSTGEADGK 40 2 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 51678400.0 21872000.0 24308000.0 5498400.0 True False 29958669.46857533 23233992.18419342 4199791.163102586 1.0 0.7755348483871872 0.1401861710683744 24.83647021612191 -7.142423261725138 0.6150067244471848 1.0018032616903534 7.522347403332732e-19 0.9983111864058493 0.014964088951592267 0.08092499184424135 0.05065674155793426 0.014775415522512797 0.049836192582854585 7.204050329743545e-08 7.142423261725138 -1.0018032616903534 down AKPSPAPPSTTTAPDASGPQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKPSPAPPSTTTAPDASGPQKR 22 2 Q5QNY5;P40855;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 30851300.0 7221800.0 1096900.0 22532600.0 True False 9467849.736010682 933246.7956827127 20201142.69996143 1.0 0.09857008948221227 2.133656877033757 23.174605378604085 -6.786292170342665 1.511127437128568 0.4937608391905855 2.1531444843767447 0.78910321582408 0.3823690858854554 0.24091245699742572 1.086821687700288 0.19921517416631432 0.4676997511159263 1.6357157282188903e-07 6.786292170342665 1.6593836451861592 AKPSPAPPSTTTAPDASGPQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKPSPAPPSTTTAPDASGPQKR 22 2 Q5QNY5;P40855;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 61991600.0 6016200.0 14487200.0 41488200.0 True False 5825219.024101388 20272014.509749953 30621195.800679017 1.0 3.4800433126850816 5.256659994068243 22.473880864420607 -8.031664027932537 0.2540962726890859 4.234568608439312e-15 6.8035976774681295 0.9995328905067113 0.037728574753196596 0.1012419885459437 0.04983061611625259 0.42177897462884634 0.5811781378372057 9.296853171953058e-09 8.031664027932537 6.803597677468125 AKPSPAPPSTTTAPDASGPQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKPSPAPPSTTTAPDASGPQKR 22 2 Q5QNY5;P40855;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 187632800.0 16240400.0 115028000.0 56364400.0 True False 24637874.132276807 94500354.68213403 45223951.634605914 1.0 3.835572589371012 1.835546013093733 24.554374443331426 -9.20198202403163 9.680515778391118 1.000040457825728 2.835559301231338 0.528982374092204 0.8165074309833387 0.0 0.0 0.790579920411519 0.2635266401371729 6.280843554384631e-10 9.20198202403163 1.83551884340561 AKPSPAPPSTTTAPDASGPQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKPSPAPPSTTTAPDASGPQKR 22 2 Q5QNY5;P40855;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 34041790.0 7221800.0 967990.0 25852000.0 True False 9891894.62180676 925221.0010851301 19746290.038652726 1.0 0.09353324478866497 1.996209097812453 23.237815440126976 -6.77716936153915 1.5470593167520674 0.4848458613348309 2.009924637740768 0.7571921911427046 0.3828965677553232 0.2549971449202975 1.20529198679799 0.19498278256713683 0.46114749941773137 1.6704390672310274e-07 6.77716936153915 1.525078776405937 AKPSPAPPSTTTAPDASGPQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKPSPAPPSTTTAPDASGPQKR 22 2 Q5QNY5;P40855;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 46576700.0 6016200.0 17493600.0 23066900.0 True False 5002736.862850136 17399358.50459228 27890082.140704744 1.0 3.477967956659547 5.574964845305762 22.254286139854884 -7.541220239953218 0.2408635138874361 1.5873728051914113e-14 7.908654840919346 0.9998625320174842 0.02192372013039796 0.13567179748479608 0.02637266764696296 0.21998872535323796 0.49795168099605897 2.875939594833828e-08 7.541220239953218 7.90865484091933 AKPSPAPPSTTTAPDASGPQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKPSPAPPSTTTAPDASGPQKR 22 2 Q5QNY5;P40855;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 161144700.0 16240400.0 101860000.0 43044300.0 True False 21023517.94614384 96191401.45786378 35210679.0718151 1.0 4.575418904879681 1.6748233650531115 24.325500765423875 -6.594204691121611 2.2122213488569136 3.413436504409654 1.6835577805631532 0.004380836788204445 1.5476722846324433 0.6573291086740978 6.070546971684715 0.5825411781167347 1.7240012316762239 2.5456301666305703e-07 6.594204691121611 -1.7298787238465008 AKPVATAPIPGTPWCVVWTGDER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKPVATAPIPGTPWCVVWTGDER 23 1 O14776;O14776-2;G3V220 O14776 TCERG1 Transcription elongation regulator 1 0 14574200.0 2702400.0 5125300.0 6746500.0 False True 3701550.309614025 4898847.298899398 5153115.648528959 1.0 1.3234582510402837 1.3921506443245653 21.819698206429873 -12.549355308088343 0.24058795350627588 5.448039710455945e-12 1.424244113600198 0.9994261570433519 0.004095969691033168 6.822217296540008 0.1469725636310002 3.3345130242054677 0.03342256111193842 2.822569809165872e-13 12.549355308088343 1.42424411359475 AKVEFNIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AKVEFNIR 8 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 104288000.0 33046000.0 28377000.0 42865000.0 False True 43323626.01791923 24143262.21267963 38429740.99011423 1.0 0.55727704330874 0.8870388866855045 25.36865066013901 -10.291488559859415 5.815593445518129 1.000021056318776 0.7221579649971214 0.48626498684078345 0.1346247088187816 3.6756792790502556e-05 4.477845488505028e-06 0.13035968273637136 0.043449937936929535 5.111065423760487e-11 10.291488559859415 -0.27786309132165454 AKVEFNIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AKVEFNIR 8 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 45876000.0 17203000.0 8179000.0 20494000.0 False True 16656900.18144612 11444917.35292153 15126006.59317868 1.0 0.6870976729313572 0.9080925279258935 23.98961660699461 -10.07830352007843 5.583132899671547 1.000001446328928 0.797595101673736 0.5279566904962678 0.09022077175303467 1.6242629082004251e-06 2.6812565714362913e-07 0.08735651141106275 0.02911862887342707 8.350192353397757e-11 10.07830352007843 -0.20240634465519192 AKVEFNIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AKVEFNIR 8 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 170032000.0 34981000.0 57057000.0 77994000.0 False True 53068734.453657314 46874732.56162422 62578451.71401535 1.0 0.8832834067780144 1.179196232174379 25.661358808981365 -6.7997532801707345 1.457412884651883 0.9355817562852525 1.1832330711405086 0.8312935730024911 0.049987004399298554 0.22111902567563002 0.9273442026478637 0.0269855719474948 0.0627541509045864 1.5857938156198758e-07 6.7997532801707345 0.24765131485525604 AKVEFNIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AKVEFNIR 8 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 74717000.0 33046000.0 16167000.0 25504000.0 False True 45263999.234571196 15452688.482880313 19480480.471367758 1.0 0.3413902603435457 0.4303747083949487 25.431860721661902 -10.722500806529592 6.906489352802733 1.0074422833711145 0.3858824843713797 0.9844975209018764 0.0363277487948557 0.004155162436011739 0.00016695208599124716 0.035108168709021954 0.011724730507306888 1.8945199960345286e-11 10.722500806529592 -0.6215597989997348 AKVEFNIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AKVEFNIR 8 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 39127000.0 17203000.0 12544000.0 9380000.0 False True 14305056.722118758 12476422.982210957 11341314.6317802 1.0 0.8721687179974384 0.7928185712290142 23.770021882428885 AKVEFNIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AKVEFNIR 8 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 181531000.0 34981000.0 80364000.0 66186000.0 False True 45283594.07859774 75891672.75436652 54140827.12570895 1.0 1.6759198181717425 1.1955947452346187 25.432485131073815 -10.363080323502547 6.358147379709025 0.9999611299158458 1.4357572817031807 0.5232149570206389 0.19609188989351128 0.00010805534266154849 1.0824143928935019e-05 0.18988203111686439 0.06328838532365895 4.3343070722790804e-11 10.363080323502547 0.4357961517873349 ALAAAGYDVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALAAAGYDVEK 11 0 P10412;Q02539;P22492;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1T;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1t;Histone H1.3;Histone H1.2 0 35080900.0 9573900.0 13915000.0 11592000.0 False True 12551475.613779482 11838936.240245163 10392571.03831572 1.0 0.9432306291738267 0.8279959550657428 23.581353648749122 -6.959753775962622 0.43888997772012117 1.0041683129857755 0.7625737076678467 0.9997609521106232 0.001106382689881408 0.07978918916972544 0.021457178936379953 0.0015172322392133747 0.009549945417959003 1.0971000226841406e-07 6.959753775962622 -0.24159460531792876 ALAAAGYDVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALAAAGYDVEK 11 0 P10412;Q02539;P22492;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1T;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1t;Histone H1.3;Histone H1.2 0 28098000.0 8742900.0 3667100.0 15688000.0 False True 8465361.42512151 5131392.15367387 11578842.170088157 1.0 0.6061633870050875 1.3677906457398488 23.013140234030946 -6.766176350106855 1.5891698782529 0.773000089653286 1.371459850869314 0.7156688367209629 0.16583023591552645 0.2726704513714969 1.3584079126900357 0.08228218323460794 0.19655449114020054 1.713261477356527e-07 6.766176350106855 0.5984597612160281 ALAAAGYDVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALAAAGYDVEK 11 0 P10412;Q02539;P22492;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1T;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1t;Histone H1.3;Histone H1.2 0 26901300.0 9573900.0 8240600.0 9086800.0 False True 13113629.554919232 7876503.043979924 6940684.988520404 1.0 0.6006348594028464 0.5292726136157163 23.644563710272013 -13.999999999999998 0.2422234032830019 3.672181630957164 0.49837889162990046 0.9995287049923286 0.004496904993119248 13.702972469048033 0.1557599349162742 17.734736376182344 0.034420520122506515 1.0000000000000041e-14 13.999999999999998 -3.1738027393272636 ALAAAGYDVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALAAAGYDVEK 11 0 P10412;Q02539;P22492;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1T;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1t;Histone H1.3;Histone H1.2 0 15286400.0 8742900.0 4010200.0 2533300.0 False True 7270108.726141495 3988596.256637619 3063001.317344217 1.0 0.5486295194314802 0.4213143754412406 22.793545509465222 -13.999999999999996 0.1775312822893519 3.32461603584577 0.31756131759147876 0.9995013237589723 0.005544526876358223 12.173817304278082 0.1335444245151574 9.756526318790856 0.09709086872885772 1.0000000000000082e-14 13.999999999999996 -3.0070547182542913 ALAAAGYDVEK(ub)NNSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALAAAGYDVEKNNSR 15 1 P10412;Q02539;P22492;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1T;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1t;Histone H1.3;Histone H1.2 1 51235700.0 18462900.0 21058100.0 11714700.0 True False 24205040.694977947 17916313.563830882 10502575.219337236 1.0 0.7401893592993691 0.4339003330622909 24.528804183958478 -6.968950963716494 0.2821176191556238 1.06577951774758 0.0989497648132839 0.9999730046387596 0.001202110001805787 0.07664455943593387 0.010242988937406536 0.005589393399432319 0.028039122085514425 1.0741106835633993e-07 6.968950963716494 -0.9668297529342961 down ALAAAGYDVEK(ub)NNSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALAAAGYDVEKNNSR 15 1 P10412;Q02539;P22492;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1T;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1t;Histone H1.3;Histone H1.2 1 90521600.0 27911400.0 37312900.0 25297300.0 True False 27025367.884927947 52212135.554203026 18671178.227267418 1.0 1.9319676156313026 0.6908760060831711 24.687810921103885 -6.7057257819323635 1.8101459248556804 1.5754168843450442 0.6940966255384323 0.4449780679557085 0.3929960970072682 0.3836972013903626 2.447927771273663 0.17293915669175827 0.4416875617581986 1.9691292260047854e-07 6.7057257819323635 -0.8813202588066119 ALAAAGYDVEK(ub)NNSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALAAAGYDVEKNNSR 15 1 P10412;Q02539;P22492;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1T;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1t;Histone H1.3;Histone H1.2 1 129314100.0 56300000.0 41242100.0 31772000.0 True False 85411216.08132708 33882125.02900194 25492250.273837723 1.0 0.396694094564114 0.29846490242644996 26.347922199190837 -13.999999999999998 0.2554389261754123 5.313455332338199 0.2609627740798876 0.9995531738398111 0.006556186011866474 14.220287343782594 0.15992736433478144 31.5759104330114 0.04400162543076074 1.0000000000000041e-14 13.999999999999998 -5.052492558258312 ALAAAGYDVEK(ub)NNSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALAAAGYDVEKNNSR 15 1 P10412;Q02539;P22492;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1T;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1t;Histone H1.3;Histone H1.2 1 40183400.0 18462900.0 13300100.0 8420400.0 True False 25289133.07111193 12712457.604450835 6431674.943581593 1.0 0.5026845945530819 0.2543256396135054 24.59201424548137 -9.597587598170032 0.19071653245554146 1.5394999225919992 5.965451021330416e-11 0.9995393920838126 0.006653668035292672 1.0320836433705383 0.07779678157480721 0.46021062549573893 0.15099103735076613 2.5258781834584837e-10 9.597587598170032 -1.5394999225323447 ALAAAGYDVEK(ub)NNSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALAAAGYDVEKNNSR 15 1 P10412;Q02539;P22492;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1T;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1t;Histone H1.3;Histone H1.2 1 80057700.0 27911400.0 43556500.0 8589800.0 True False 23209565.784673937 43321852.48921168 10385887.465252182 1.0 1.866551614585507 0.4474830577015937 24.46821619653816 -6.741464826941288 1.6814665428220998 1.5147325990173914 0.4464109574619502 0.6113993274177421 0.36407899320140014 0.3151958350994487 1.750379090990851 0.17125795046372344 0.41955610953793493 1.8135735493600115e-07 6.741464826941288 -1.0683216415554413 ALAAAGYDVEK(ub)NNSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALAAAGYDVEKNNSR 15 1 P10412;Q02539;P22492;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1T;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1t;Histone H1.3;Histone H1.2 1 104942700.0 56300000.0 41686100.0 6956600.0 True False 72881459.83891395 39366231.88997306 5690570.180743757 1.0 0.5401405512044102 0.07807980511533831 26.119048521283286 -7.834402051525501 0.48438167950140204 1.0260501810244531 9.075518741464485e-22 0.9953775218064052 0.025589131164971485 0.10991929666335454 0.1019570051591046 0.03495374450788806 0.07786032402827608 1.4641917263524399e-08 7.834402051525501 -1.0260501810244531 down ALAAPAAEEK(ub)EEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALAAPAAEEKEEAR 14 1 Q01650 Q01650 SLC7A5 Large neutral amino acids transporter small subunit 1 1 11319700.0 3966000.0 3705600.0 3648100.0 True False 5199464.406798636 3152738.9243156672 3270629.6070462074 1.0 0.606358401106325 0.6290320216000802 22.309931589221808 -10.399899961661061 5.8889356435561275 1.0001118044867905 0.6176952113532034 0.9973688868861315 0.009256466805203107 1.3591554726541775e-05 1.3850223769269595e-06 0.008965135769617539 0.002987511815105953 3.981988838240243e-11 10.399899961661061 -0.3824165931335871 ALAAPAAEEK(ub)EEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALAAPAAEEKEEAR 14 1 Q01650 Q01650 SLC7A5 Large neutral amino acids transporter small subunit 1 1 12522500.0 3753200.0 3984700.0 4784600.0 True False 3634056.720397808 5575811.4899359895 3531369.7250767383 1.0 1.534321536215765 0.971743150087699 21.793149506672215 -8.772806513555107 18.63388791952109 1.000000528603764 1.2530323431517287 0.21242924518579298 0.22967166438890518 0.0 0.0 0.22237863281840042 0.07412621093946678 1.6873045842167503e-09 8.772806513555107 0.25303181454796464 ALAAPAAEEK(ub)EEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALAAPAAEEKEEAR 14 1 Q01650 Q01650 SLC7A5 Large neutral amino acids transporter small subunit 1 1 15895000.0 6239600.0 3533600.0 6121800.0 True False 9465929.375862317 2903001.471857184 4911823.546719742 1.0 0.30667897008187106 0.5188950130184433 23.17431272766991 -10.190551138221982 5.134502360167507 1.0000409900019025 0.4127869915499538 0.9107841872941919 0.0866368367392177 4.065474414921589e-05 6.409230317816976e-06 0.08389159081653215 0.027961918821395235 6.44835385961487e-11 10.190551138221982 -0.5872539984519487 ALAAPAAEEK(ub)EEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALAAPAAEEKEEAR 14 1 Q01650 Q01650 SLC7A5 Large neutral amino acids transporter small subunit 1 1 10594600.0 3966000.0 3078600.0 3550000.0 True False 5432337.377120057 2942577.27243121 2711563.1145449937 1.0 0.5416779312759127 0.4991521929336656 22.3731416507447 -13.999999999999991 0.33636407838424726 6.184951863698437 0.49217067552128607 0.9997278940378862 0.00374028378330259 19.375558903886564 0.1858227723484028 71.30193079971647 0.01331223736808367 1.0000000000000205e-14 13.999999999999991 -5.692781188177151 ALAAPAAEEK(ub)EEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALAAPAAEEKEEAR 14 1 Q01650 Q01650 SLC7A5 Large neutral amino acids transporter small subunit 1 1 11030600.0 3753200.0 5670300.0 1607100.0 True False 3120952.0949518136 5639752.968433578 1943137.1796091623 1.0 1.8070616904232404 0.6226103831430849 21.57355478210649 -6.723231161992779 1.7475152974302761 1.4892966416856237 0.6240890729749244 0.527809157859829 0.33948652734341705 0.34907130139801246 2.0849485034327033 0.15414404647564595 0.3855217358198627 1.891336648620698e-07 6.723231161992779 -0.8652075687106993 ALAAPAAEEK(ub)EEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALAAPAAEEKEEAR 14 1 Q01650 Q01650 SLC7A5 Large neutral amino acids transporter small subunit 1 1 19143500.0 6239600.0 6514800.0 6389100.0 True False 8077285.200903864 6152245.65303055 5226349.35770204 1.0 0.7616724555351967 0.6470428154644338 22.94543904976236 -13.999999999999364 0.09674728159808173 2.1890992916422416 0.3900984275708816 0.9998098933454879 0.002027012258893103 12.105950309389211 0.09195589582352341 2.8991700741965096 0.22962705326213304 1.0000000000014643e-14 13.999999999999364 -1.79900086407136 ALACIPVQELK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALACIPVQELKR 12 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0;H0Y2P2 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 42327000.0 13107000.0 16129000.0 13091000.0 True False 17183403.928368557 13722616.070349589 11736468.897739077 1.0 0.798597072358553 0.6830118727735321 24.034512518158333 -13.999975640443516 0.06284112104659668 2.2440603401975183 0.19377456545440583 0.9999465943216947 0.0009571821935628297 12.434637528935689 0.06518278301285184 2.381590797032778 0.45618124366960217 1.0000560915247026e-14 13.999975640443516 -2.0502857747431125 ALACIPVQELK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALACIPVQELKR 12 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0;H0Y2P2 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 36057800.0 16187000.0 11095000.0 8775800.0 True False 15673152.545315836 15525291.359660642 6477154.711643275 1.0 0.9905659575999352 0.413264318899204 23.901792061255417 -6.910448638423463 0.8926568218019406 1.0176220983665574 0.3379330730068424 0.9910900780299928 0.025900632911350353 0.1041228033711472 0.1371574946668962 0.021252286039018423 0.05885120350880516 1.2289985247578994e-07 6.910448638423463 -0.679689025359715 down ALACIPVQELK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALACIPVQELKR 12 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0;H0Y2P2 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 77358000.0 17356000.0 21078000.0 38924000.0 True False 26330320.893561527 17316466.21683431 31230654.339004762 1.0 0.6576625589499995 1.1861099021638395 24.650221768152626 -6.731823661009289 1.7164678922467926 0.794403238100992 1.1859081018825377 0.5677407579227363 0.14389114359187044 0.33283456608829626 1.9219150574027188 0.06640786633648042 0.16445458682936404 1.8542843759241408e-07 6.731823661009289 0.3915048637815457 ALACIPVQELK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALACIPVQELKR 12 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0;H0Y2P2 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 40843000.0 13107000.0 14229000.0 13507000.0 True False 17953012.103356674 13600315.730989307 10316924.78539697 1.0 0.7575506356644441 0.5746626095945212 24.097722579681225 -6.988852340592051 0.11997877665647694 1.3301806249291932 1.0909236369493789e-12 0.999999470098094 0.00012668344854548783 0.07348387337343353 0.003542694340217141 0.012828962428663188 0.02603825360111981 1.0260007055044572e-07 6.988852340592051 -1.3301806249281023 ALACIPVQELK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALACIPVQELKR 12 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0;H0Y2P2 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 37992800.0 16187000.0 8474800.0 13331000.0 True False 13460207.705687165 8429144.570283912 16118450.464420237 1.0 0.62622693160392 1.1974889850778394 23.682197336689693 -6.730186910751651 1.7227320186750337 0.7751105615086696 1.197149417974754 0.5600666088652388 0.15712264019501188 0.3358802731621929 1.952999388150814 0.07227718482172353 0.17930044524947697 1.8612859079198182e-07 6.730186910751651 0.4220388564660843 ALACIPVQELK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALACIPVQELKR 12 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0;H0Y2P2 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 48642000.0 17356000.0 21363000.0 9923000.0 True False 22467684.13790749 20174130.270413764 8117115.8185781 1.0 0.8979176557131654 0.3612795946727281 24.421348090245075 -6.938694673474238 0.6716048756446166 1.006181246072117 0.22196173092868562 0.9979877716792017 0.012567008384222344 0.08836743263656976 0.057361221963564586 0.012115208388636934 0.0464593677543029 1.1516097324700714e-07 6.938694673474238 -0.7842195151434312 down ALADDDFLTVTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALADDDFLTVTGK 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 14189700.0 1143400.0 7140800.0 5905500.0 False True 1499008.472701352 6075420.474620392 5294455.509556032 1.0 4.05295939633478 3.5319717039456973 20.515577107039352 -9.316646074463636 8.274723990569909 1.0000000207490969 3.792465550144269 0.9745581720794569 0.21269233478507818 0.0 1.3133606957775865e-18 0.20593846454690934 0.06864615587187715 4.823407180114544e-10 9.316646074463636 2.792465529395172 ALADDDFLTVTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALADDDFLTVTGK 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 16537100.0 6236800.0 1523300.0 8777000.0 False True 6038816.197851718 2131561.6339045577 6478040.395644046 1.0 0.3529767365105186 1.0727334933539756 22.52583433197452 -6.669814574112669 1.9380974605370527 0.5869430245853072 1.0698187101044945 0.27822550995737494 0.2748527789645136 0.4615248588481147 3.342044343027784 0.1141787805696079 0.3051233842332942 2.1388751063064984e-07 6.669814574112669 0.48287568551918725 ALADDDFLTVTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALADDDFLTVTGK 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 17078200.0 1143400.0 8420300.0 7514500.0 False True 1566145.8792231658 8048263.303791487 5739729.86598545 1.0 5.138897602427405 3.6648756301248584 20.578787168562243 -9.764038899706298 9.274191527274104 1.0000024826058909 4.401886616276132 0.8765711502283111 0.6017669503003932 0.0 0.0 0.5826583355198268 0.19421944806736363 1.7217143543246175e-10 9.764038899706298 3.401884133670241 ALADDDFLTVTGK(ub)TVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALADDDFLTVTGKTVR 16 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 39410000.0 15040000.0 10857000.0 13513000.0 True False 14562563.432479769 15192256.718507035 9973539.918689532 1.0 1.0432405523208106 0.6848752944447226 23.79576099816899 -6.876752509829038 1.0978106345917247 1.0258014553370645 0.6610140785756843 0.9709674418664395 0.027214876535692992 0.1305426852796579 0.29003424683329143 0.019149653537567275 0.045947778090624836 1.3281511118395766e-07 6.876752509829038 -0.3647873767613802 ALADDDFLTVTGK(ub)TVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALADDDFLTVTGKTVR 16 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 40042300.0 15040000.0 15312000.0 9690300.0 True False 12506426.384971572 15229511.216805963 11716496.92711509 1.0 1.217734846711016 0.9368381155782673 23.576166273603267 -6.699779295970867 1.8314616200448948 1.1352376921024703 0.9376738045393963 0.4164873105044906 0.09191312657570357 0.3960530254228912 2.5825222758101707 0.04003741408692349 0.10300118657762895 1.9962765446292877e-07 6.699779295970867 -0.19756388756307397 ALADDDFLTVTGK(ub)TVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALADDDFLTVTGKTVR 16 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 83805000.0 20848000.0 18465000.0 44492000.0 True False 26988146.975518316 17437406.5179605 36394912.52647148 1.0 0.6461135154547085 1.348551738638681 24.68582258799647 -6.769743713506121 1.5755286727086004 0.7969536340596345 1.3524558735675682 0.7295514304865276 0.14913481143297655 0.2668411594788306 1.307200711686579 0.07461432417421113 0.17764804475246096 1.6992461182451452e-07 6.769743713506121 0.5555022395079338 ALAEIAK(ub)AELDDTPMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALAEIAKAELDDTPMR 16 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 10339900.0 2673000.0 3666400.0 4000500.0 True False 2588147.0781262233 5130412.640023417 2952649.0375725226 1.0 1.9822724463316639 1.1408351026596961 21.303488173847068 -10.189791342889038 4.449171268407265 0.9998833896143624 1.5615537743006196 0.37258898418964725 0.3435153573825014 241242174.39931008 89.74078929232374 344797.9743523961 0.1175944437580741 6.45964508626397e-11 10.189791342889038 0.5616703846862572 ALAEIAK(ub)AELDDTPMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALAEIAKAELDDTPMR 16 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 6798600.0 2673000.0 2013600.0 2112000.0 True False 2222717.9339779913 2002752.3371316951 2553609.435215326 1.0 0.9010375570000353 1.1488679675360962 21.083893449281344 -6.798332327170577 1.4626205882928707 0.9452819240410592 1.152153411969222 0.8272683577282234 0.042333126813776774 0.22314627862887174 0.9425913499031819 0.022771063262005144 0.053013957039489246 1.59099081652023e-07 6.798332327170577 0.2068714879281629 ALAENSGVK(ub)ANEVISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALAENSGVKANEVISK 16 1 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 1 30155800.0 7436100.0 8832700.0 13887000.0 True False 7200045.07581535 12359643.171921998 10249578.098930039 1.0 1.7166063603459265 1.4235436016029874 22.779574507886306 -10.258390273029015 5.058336081355571 0.9998989396154478 1.5700749809745984 0.8345804688496783 0.119642370256306 0.0001363928026047861 1.999694138261286e-05 0.1158636015662525 0.03861440895849543 5.5158154499271794e-11 10.258390273029015 0.5701760413591506 ALAENSGVK(ub)ANEVISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALAENSGVKANEVISK 16 1 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 1 57166000.0 10467000.0 16571000.0 30128000.0 True False 15879204.240199838 13613775.580186049 24173187.59442848 1.0 0.8573336153534303 1.5223173169617386 23.920635280251414 -6.85057571293745 1.2322480729390781 0.9238264362128128 1.5492062671933242 0.9411456984502325 0.06934601544023153 0.15682625781603182 0.4579441400758926 0.044028345320635154 0.1019261832012622 1.4106662858341208e-07 6.85057571293745 0.6253798309805114 ALAENSGVK(ub)ANEVISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALAENSGVKANEVISK 16 1 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 1 11747300.0 7436100.0 0.0 4311200.0 True False 6183446.625085582 0.0 5212651.987263405 1.0 0.0 0.8430010483338262 22.559979783320582 -9.732808951518527 11.071030349981916 1.0000079855903334 0.4215005242043169 0.3857105419343343 0.34415373687241124 0.0 0.0 0.3332254228465204 0.11107514094884012 1.8500823011612312e-10 9.732808951518527 -0.5785074613860166 ALAENSGVK(ub)ANEVISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALAENSGVKANEVISK 16 1 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 1 61282000.0 10467000.0 24234000.0 26581000.0 True False 13549737.835415857 22885356.596601903 21743530.744091943 1.0 1.6889888848465329 1.6047196638195775 23.691761602343863 -10.523362787369967 5.954917636575412 0.999061420826236 1.6468542743330457 0.9874312182944265 0.03440276542297621 0.0004292391539191161 3.4356697917751987e-05 0.0333531121342269 0.011103444795555565 2.99665821833425e-11 10.523362787369967 0.6477928535068097 ALAESWNAAFLESSAK(ub)ENQTAVDVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALAESWNAAFLESSAKENQTAVDVFR 26 1 Q15382;C9J931 Q15382 RHEB GTP-binding protein Rheb 1 8264100.0 2332000.0 2558700.0 3373400.0 True False 1939161.3251166018 2544915.7752378182 4078762.3431606973 1.0 1.3123796056961854 2.1033641143371304 20.887001400238763 -6.955187619345557 0.49865524170297937 0.983972711588872 2.465808733351994 0.9995479923652952 0.009872454732916851 0.08146718269427174 0.02784127408201865 0.011607330566286154 0.06524627038571255 1.108695744684885e-07 6.955187619345557 1.481836021763122 up ALAFNGVMFGDRPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALAFNGVMFGDRPLK 15 1 Q8WXA9;Q8WXA9-2 Q8WXA9 SREK1 Splicing regulatory glutamine/lysine-rich protein 1 0 11323400.0 4148700.0 4074800.0 3099900.0 False True 5438985.876067945 3466855.7234459934 2779152.084340488 1.0 0.6374084806324812 0.510968799637635 22.374906248748804 -13.999999999999995 0.1468991036755578 2.745451730617724 0.36677556200048855 0.9995769171199776 0.004263126725302695 11.94743389003922 0.12053936601985124 5.9586083390855995 0.12959704204475903 1.0000000000000123e-14 13.999999999999995 -2.3786761686172357 ALAFNGVMFGDRPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALAFNGVMFGDRPLK 15 1 Q8WXA9;Q8WXA9-2 Q8WXA9 SREK1 Splicing regulatory glutamine/lysine-rich protein 1 0 14827000.0 4148700.0 3951100.0 6727200.0 False True 5682586.504401904 3776527.337459539 5138373.911032979 1.0 0.6645789438549025 0.904231533836333 22.438116310271695 -10.014718439719797 5.8985933137923645 1.0000003325546156 0.7844052388455854 0.5190164436413776 0.09783776016527107 4.277928666455986e-07 7.155439605262078e-08 0.09473114933073629 0.031577001312510726 9.666773887847178e-11 10.014718439719797 -0.21559509370903018 ALAFNGVMFGDRPLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALAFNGVMFGDRPLK 15 1 Q8WXA9;Q8WXA9-2 Q8WXA9 SREK1 Splicing regulatory glutamine/lysine-rich protein 1 0 8244100.0 3110600.0 1774200.0 3359300.0 False True 2586601.7229449833 1764642.0324488722 4061714.098351728 1.0 0.6822240999823249 1.5702897211895657 21.3026264986592 -6.809957419041969 1.4148595302890354 0.8268080448409484 1.585789041993715 0.8596794586210542 0.1376273380907904 0.2068600527949861 0.8161840501160769 0.0764888391540618 0.17692568162733135 1.5489684820638277e-07 6.809957419041969 0.7589809971527667 ALALNCFAPINDQEGAEAK(ub)DWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALALNCFAPINDQEGAEAKDWR 22 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2;A0A087WWG9 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 6603000.0 1320000.0 2622800.0 2660200.0 True False 1808039.671658715 2506916.023560243 2031915.5485387573 1.0 1.3865381732804412 1.1238224361939226 20.785994902761665 -10.549205803461643 5.310561695183402 0.9989699065272486 1.2551803047371612 0.557118966475592 0.10725325054352788 0.0013131370100415466 0.00011146730282068026 0.10425015305024099 0.034615837765140836 2.8235416379721872e-11 10.549205803461643 0.25621039820991265 ALALNCFAPINDQEGAEAK(ub)DWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALALNCFAPINDQEGAEAKDWR 22 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2;A0A087WWG9 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 29734100.0 4856700.0 6823400.0 18054000.0 True False 6287093.889869509 6443671.791749345 14768357.24968344 1.0 1.02490465461827 2.3489958172057714 22.583961877444157 -6.910972380586609 0.8890693148639923 0.9602531505900989 2.5237300386409314 0.9912837314048504 0.05882997692208757 0.10377908236328498 0.13529903964251036 0.04839758436621158 0.13451976235509086 1.22751729392679e-07 6.910972380586609 1.5634768880508325 up ALALSFHGWSGTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALALSFHGWSGTGK 14 0 Q9H497;Q5W0C6;Q9H497-2 Q9H497 TOR3A Torsin-3A 0 7138900.0 3205900.0 1546400.0 2386600.0 False True 3104130.4593209396 2163885.584369469 1761477.8635347022 1.0 0.6970987890898249 0.5674625749847008 21.5657577612114 -13.999999999598204 0.11586274161286945 2.449266506289824 0.34853198032812166 0.9997134597829874 0.0030679960868661336 11.981541448285617 0.10420031817810174 4.021961340105018 0.19427712863377025 1.0000000009251693e-14 13.999999999598204 -2.1007345259617023 ALALSFHGWSGTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALALSFHGWSGTGK 14 0 Q9H497;Q5W0C6;Q9H497-2 Q9H497 TOR3A Torsin-3A 0 5594300.0 2605700.0 2988600.0 0.0 False True 3569097.7063947837 2856553.7700214097 0.0 1.0 0.800357402629605 0.0 21.767127965976382 -7.250158872233309 0.8529975228050981 0.9892870770457726 9.626991337726372e-17 0.9888199101414884 0.045688982958556494 0.0984199539025262 0.13816871412845258 0.038717750405742705 0.06817977367636095 5.621356488881765e-08 7.250158872233309 -0.9892870770457725 down ALAMAESTEK(ub)HAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALAMAESTEKHAR 13 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 3608720.0 1241900.0 978620.0 1388200.0 True False 1628142.9265767077 832613.7106308835 1244562.3805546842 1.0 0.5113885869845076 0.7644060974250397 20.634795921515895 -10.072139658095995 4.991838226527559 1.000008454792754 0.6378973422028413 0.7319659923008094 0.10329396610146838 9.71960809809569e-06 1.8066234070528452e-06 0.10001628701419671 0.03333798420526689 8.469550110827683e-11 10.072139658095995 -0.3621111125899126 ALAMAESTEK(ub)HAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALAMAESTEKHAR 13 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 4063140.0 971540.0 1208500.0 1883100.0 True False 940698.9944941084 1691060.3522442458 1389859.6182109276 1.0 1.7976636119970222 1.4774753947285444 19.84337363668872 -10.12871040107771 4.450825372590147 0.9999212271048772 1.6375695033885092 0.8409335569672636 0.1307162924548209 68977370.89286894 10.112659045708774 59693.80699018211 0.04783726473246023 7.435147677273847e-11 10.12871040107771 0.637648276283632 ALAMAESTEK(ub)HAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALAMAESTEKHAR 13 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 3710000.0 1241900.0 1176700.0 1291400.0 True False 1701063.9910855764 1124709.5031734565 986397.9172178603 1.0 0.6611800079641302 0.5798711408783428 20.698005983038787 -13.99999999999998 0.2004776643737643 2.88688393995341 0.5273132834838254 0.9994869555218947 0.004121017653040748 12.54041536602733 0.14197185090666295 9.28033020114398 0.051589573047431135 1.000000000000045e-14 13.99999999999998 -2.359570656469584 ALAMAESTEK(ub)HAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALAMAESTEKHAR 13 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 4223740.0 971540.0 1911400.0 1340800.0 True False 807878.5565196327 1901102.9088168074 1621155.0808412468 1.0 2.3532038243555085 2.0066816574823276 19.623778912122997 -10.528532762793969 5.184264726471319 0.9957572255253546 2.179942740918925 0.9392452223140209 0.14146708223384724 0.0069443501446121965 0.0006315324000304165 0.13711291980551044 0.04565830446068171 2.961196566901869e-11 10.528532762793969 1.1841855153935703 ALANECSQGDK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALANECSQGDKR 12 1 Q6PL18;Q6PL18-2 Q6PL18 ATAD2 ATPase family AAA domain-containing protein 2 1 2159420.0 424410.0 796730.0 938280.0 True False 556405.6199922861 677860.989629215 841195.7862172953 1.0 1.218285662964031 1.5118391259760415 19.08577746637673 -6.967008490176821 0.32172220865815004 0.9606017853591378 1.7790154727822847 0.9999487610409531 0.0015011166138185188 0.07728585138147763 0.012490873116865671 0.004419068155722453 0.02578262723008693 1.0789256297239513e-07 6.967008490176821 0.8184136874231469 ALANECSQGDK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALANECSQGDKR 12 1 Q6PL18;Q6PL18-2 Q6PL18 ATAD2 ATPase family AAA domain-containing protein 2 1 5010120.0 581260.0 581560.0 3847300.0 True False 881813.9157980862 477776.07425098075 3086879.468668505 1.0 0.5418105404002036 3.5006018995228976 19.750114718564976 -6.867364522170687 1.1480228677970756 0.744594459706581 3.6653650658013763 0.961977233422605 0.25355416035345324 0.13940273499267256 0.3450457895060812 0.17167365053610845 0.4046637769319606 1.357173833604508e-07 6.867364522170687 2.9207706060947953 up ALANECSQGDK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALANECSQGDKR 12 1 Q6PL18;Q6PL18-2 Q6PL18 ATAD2 ATPase family AAA domain-containing protein 2 1 2244030.0 424410.0 595420.0 1224200.0 True False 581325.8462489967 569112.3756093645 935069.1731904171 1.0 0.9789903189090257 1.6085112664849641 19.14898752789962 -6.899181524448126 0.9664560296103266 0.9732349060865992 1.6734958949804188 0.9861535090654066 0.034352082987338675 0.11201011816490242 0.18085090925906794 0.026699622965217055 0.06918482503437233 1.2613002318182818e-07 6.899181524448126 0.7002609888938196 ALANECSQGDK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALANECSQGDKR 12 1 Q6PL18;Q6PL18-2 Q6PL18 ATAD2 ATPase family AAA domain-containing protein 2 1 2499640.0 581260.0 403680.0 1514700.0 True False 752452.5283475523 381214.85313676053 1239040.1421344597 1.0 0.5066297723444956 1.646668853456435 19.521241040657426 -6.789067388095078 1.4998825250315135 0.7239264773995416 1.658518009225138 0.7983640554376934 0.20962011414516304 0.23673065138006186 1.0520817807595466 0.11000818665428275 0.257751488124899 1.6252965440820908e-07 6.789067388095078 0.9345915318255963 ALANSLACQGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALANSLACQGK 11 0 P04075;J3KPS3;P04075-2;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 77850000.0 2082000.0 43162000.0 32606000.0 False True 2729522.162116683 36722397.84415828 29232243.898837395 1.0 13.453782626802665 10.709656182519671 21.380216980292378 -10.322726997694932 9.092718363768219 0.9999923024813966 12.081719404661168 0.9560328787707212 1.1202849296952113 0.00017482009905168004 1.3026464966481465e-05 1.0847119664439617 0.3615704063097252 4.756341208470597e-11 10.322726997694932 11.081727102179771 ALANSLACQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALANSLACQGK 11 0 P04075;J3KPS3;P04075-2;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 63534400.0 27119000.0 7408400.0 29007000.0 False True 26258122.18919012 10366612.754295627 21409196.508652966 1.0 0.3947964244969249 0.8153361597756085 24.646260411927113 -10.483829142025112 5.666351497667378 1.0004695898362435 0.6050662921363174 0.5404215870472019 0.17168462799964943 0.001019659143537725 9.288472483619263e-05 0.16642429580117793 0.05541097542020459 3.2822439612525585e-11 10.483829142025112 -0.3954032976999261 ALANSLACQGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALANSLACQGK 11 0 P04075;J3KPS3;P04075-2;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 392532200.0 2223600.0 388290000.0 2018600.0 False True 3373363.7669349713 318996615.7763831 1619622.825216189 1.0 94.56336102946364 0.4801210118788267 21.685756469196942 -13.948827658249257 4.688714649083774e-10 8.99790260955307 76.74118282262683 0.0 45.541821574896495 981126603.2983025 0.25922984795765786 5507764738.906982 5507764935.301561 1.1250513412580189e-14 13.948827658249257 67.74328021307376 ALANSLACQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALANSLACQGK 11 0 P04075;J3KPS3;P04075-2;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 97121000.0 2082000.0 56072000.0 38967000.0 False True 2851771.663934434 53594553.63469201 29763797.150556274 1.0 18.793423860853757 10.43694960819296 21.44342704181527 -9.719783091480613 7.859529125555723 0.9999999989216869 14.615186734523403 0.7797105777419031 3.411516327954227 8.102454895610653e-08 0.0 3.3031865054809306 1.1010621602900914 1.906412638633594e-10 9.719783091480613 13.615186735601716 ALANSLACQGK(ub)YTPSGQAGAAASESLFVSNHAY ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALANSLACQGKYTPSGQAGAAASESLFVSNHAY 33 1 P04075;J3KPS3;P04075-2;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 102643000.0 49078000.0 29769000.0 23796000.0 True False 47520045.75393895 41655916.943284154 17563113.735301998 1.0 0.8765967347544332 0.3695937884034168 25.502032889427426 -6.944259954768532 0.6186628875190738 1.0055544452856175 0.21383745935813392 0.998670325159816 0.00994693008109695 0.08587581694883484 0.046155322214018184 0.010029572788852182 0.042886310062401165 1.136946542318748e-07 6.944259954768532 -0.7917169859274836 down ALANSLACQGK(ub)YTPSGQAGAAASESLFVSNHAY ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALANSLACQGKYTPSGQAGAAASESLFVSNHAY 33 1 P04075;J3KPS3;P04075-2;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 237521000.0 70115000.0 64476000.0 102930000.0 True False 106369581.09311293 52969754.04671264 82585840.38417834 1.0 0.4979784023060541 0.7764046782499315 26.66451039602329 -10.129580584985453 5.406717277715738 1.0000071378220257 0.6371915402778654 0.6936258293716051 0.11366705117476122 9.779999872185145e-06 1.5746164788223053e-06 0.11005981297333958 0.036685883017630753 7.420264991376396e-11 10.129580584985453 -0.36281559754416026 ALANSLACQGK(ub)YTPSGQAGAAASESLFVSNHAY ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALANSLACQGKYTPSGQAGAAASESLFVSNHAY 33 1 P04075;J3KPS3;P04075-2;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 9837500.0 4571700.0 2014900.0 3250900.0 True False 6261981.035547082 1925875.0556167238 2483104.3743871334 1.0 0.30755044524794994 0.3965365529361101 22.578187708595454 -10.707282954279176 6.856913955732707 1.0063739731595134 0.3520434990971874 0.9860519406934285 0.03632842633872461 0.0035388062702518836 0.0001510690037835765 0.03516426954308935 0.011724949183650272 1.9620815125885536e-11 10.707282954279176 -0.6543304740623259 ALANSLACQGK(ub)YTPSGQAGAAASESLFVSNHAY ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALANSLACQGKYTPSGQAGAAASESLFVSNHAY 33 1 P04075;J3KPS3;P04075-2;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 104472000.0 49078000.0 25300000.0 30094000.0 True False 40810531.52404485 25163703.878343172 36386516.261065386 1.0 0.6165982882020823 0.8915962351440361 25.282438164861702 -9.969589014147752 6.152575843250355 1.000000112481637 0.7540972616730378 0.5160012780118521 0.11226744172020126 1.7327806270145671e-07 2.8959808597434977e-08 0.10870253323920348 0.036234161008626364 1.0725337959368988e-10 9.969589014147752 -0.24590285080859908 ALANSLACQGK(ub)YTPSGQAGAAASESLFVSNHAY ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALANSLACQGKYTPSGQAGAAASESLFVSNHAY 33 1 P04075;J3KPS3;P04075-2;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 203058000.0 70115000.0 98994000.0 33949000.0 True False 90765249.67327638 93484896.87728025 27770630.346156146 1.0 1.0299635291457212 0.305961041765663 26.435636718115738 -6.897246021737305 0.9785238944589236 1.0324178933804435 0.23407824810214528 0.9851453467327959 0.0407637934316219 0.11346059195838447 0.18907717356335504 0.03139907065529088 0.08062185933847428 1.2669339622025188e-07 6.897246021737305 -0.7983396452782983 down ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEK 43 0 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 0 65570000.0 24905000.0 27482000.0 13183000.0 False True 32650696.180363107 23381792.723996967 11818949.620265381 1.0 0.7161192703161816 0.3619815502547714 24.96061041755291 -6.968139249797709 0.29931419077154714 1.0619220599552806 0.005092965205378763 0.9999640123622784 0.0015656953429045892 0.07691122807396056 0.011179808818438676 0.005895331605799421 0.031784178714429415 1.0761201170631368e-07 6.968139249797709 -1.0568290947499017 down ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEK 43 0 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 0 165594000.0 126280000.0 25029000.0 14285000.0 False True 122271310.52217725 35023210.22451075 10543329.95918597 1.0 0.28643849546503664 0.08622897647992124 26.86551069180434 -10.853321374307683 0.25745686255247513 1.9162488660605024 6.772762633253182e-16 0.9991558463894854 0.0113944606275289 2.75621939754151 0.1366156292184432 1.6184340894291274 0.08730063138612178 1.4017760180648097e-11 10.853321374307683 -1.9162488660605017 ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEK 43 0 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 0 129306000.0 13587000.0 88414000.0 27305000.0 False True 20612472.34275296 72635830.918265 21908154.781793363 1.0 3.5238776654467014 1.0628591474858156 24.29701422210715 -6.640271880866598 2.0430966242793356 2.650093086206016 1.0730151631397755 0.15579441517394998 1.079810477216915 0.5326784089584927 4.249846420996688 0.4303063062654499 1.1959819511616803 2.289433952385995e-07 6.640271880866598 -1.5770779230662406 ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEK 43 0 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 0 134895000.0 24905000.0 28411000.0 81579000.0 False True 34113051.53231848 27155708.077386845 62311720.372243926 1.0 0.796050392960586 1.826624050715903 25.023820479075802 -6.855296884997817 1.2092690485622348 0.890452732196054 1.8722273914622953 0.947661459018622 0.10194125669147103 0.15172757246448465 0.42431422737161834 0.06586360993679596 0.15302034781045712 1.3954141256929008e-07 6.855296884997817 0.9817746592662413 ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEK 43 0 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 0 165403700.0 126280000.0 8997700.0 30126000.0 False True 105007415.15254061 8949227.604196379 36425207.31311405 1.0 0.08522472047517929 0.34688223931805595 26.645915967238615 -10.161080330053844 5.210519554484269 1.0000333487137951 0.21605348144392236 0.9228909723046916 0.10682123475637786 4.1384463232468384e-05 6.6632173810370885e-06 0.10343359749956581 0.03447640526914402 6.90112144209951e-11 10.161080330053844 -0.7839798672698728 ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEK 43 0 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 0 43909000.0 13587000.0 17139000.0 13183000.0 False True 17588639.339810383 16185199.583608182 10783829.269002821 1.0 0.9202075994005042 0.6131133318877342 24.0681405441996 -6.945762227570744 0.6035884245139744 1.003433514802432 0.5140702352983089 0.9988252650919096 0.00571645257482538 0.08523360496304175 0.04335992493801903 0.005846467709554915 0.025837982515835432 1.1330205122748014e-07 6.945762227570744 -0.48936327950412317 ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKK 44 1 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 1 114042000.0 44176000.0 52924000.0 16942000.0 True False 67018221.69820081 43479298.70290062 13593406.274057617 1.0 0.6487683140668574 0.20283149760779987 25.998050069923952 -7.4121455864557 0.4054119668191982 1.0334113615916287 4.9062150082051454e-23 0.9991322939140793 0.00960903888171451 0.11335177309225415 0.0419384225940838 0.015881346598708337 0.060815719870266745 3.87127848155915e-08 7.4121455864557 -1.0334113615916287 down ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKK 44 1 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 1 52261000.0 26115000.0 12709000.0 13437000.0 True False 21715779.59066043 12640534.094461005 16246614.574331628 1.0 0.5820898136163379 0.7481478851129529 24.372240410297888 -10.110405131093891 5.16064835414516 1.0000085902223868 0.6651188493641415 0.8442975733662923 0.06779292380797598 6.700504524963035e-06 1.155076024110597e-06 0.06564189888749823 0.021880072074664015 7.755233330666615e-11 10.110405131093891 -0.3348897408582453 ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKK 44 1 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 1 110632000.0 44176000.0 53300000.0 13156000.0 True False 57186702.839145 50333808.1455345 10761742.991959417 1.0 0.8801662912288133 0.18818610721849263 25.7691763920164 -6.9366509367910485 0.6900156384388145 1.0083978748483058 0.018634983104149107 0.9976915267021037 0.017191443240196808 0.08932824992117445 0.061819375228277094 0.01633694290373209 0.06048818700960765 1.1570418383259694e-07 6.9366509367910485 -0.9897628917441567 down ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKKVEAK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKKVEAK 48 2 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 1 187362000.0 55403000.0 83687000.0 48272000.0 True False 84050401.50184312 68752401.00048459 38731018.041630805 1.0 0.8179901555732239 0.46080705564245855 26.324751375324787 -6.960413950394515 0.4295598728559837 1.0142542667003245 0.25085549874549057 0.9997852449852149 0.0032820712780391257 0.07955357151821722 0.02058736736000136 0.004655629208764562 0.029660290784537597 1.095433579283779e-07 6.960413950394515 -0.763398767954834 down ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKKVEAK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALANVNIGSLICNVGAGGPAPAAGAAPAGGPAPSTAAAPAEEKKVEAK 48 2 P05386 P05386 RPLP1 60S acidic ribosomal protein P1 1 179547000.0 55403000.0 83841000.0 40303000.0 True False 71720275.65640059 79175174.6478378 32968267.54370183 1.0 1.1039440928413653 0.45967848341307394 26.095877697417237 -6.865549739068528 1.1572819875265135 1.0574752299589985 0.4249908020020664 0.9600414929082336 0.056453924684747955 0.14119860853528227 0.3562307705780671 0.03794982877435002 0.08922227239164335 1.3628569113964365e-07 6.865549739068528 -0.632484427956932 down ALAPEYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALAPEYAK 8 0 P07237;H7BZ94;I3NI03;I3L3U6;I3L0S0;I3L514 P07237 P4HB Protein disulfide-isomerase 0 13245900.0 3424600.0 2105000.0 7716300.0 False True 3315887.9475312643 2945537.4774299804 5695169.545961961 1.0 0.8883103180923179 1.7175398071584755 21.660963824567865 -6.872928045527399 1.1185453622012307 0.9355690823350709 1.768872539422227 0.967516423675936 0.06622036405090222 0.1340755901295853 0.3117502000472291 0.045860595002220755 0.10915922552305178 1.3398986651839837e-07 6.872928045527399 0.8333034570871563 ALAPTWEQLALGLEHSETVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALAPTWEQLALGLEHSETVK 20 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 43979400.0 7030400.0 24498000.0 12451000.0 False True 9216922.482490437 20842993.89245609 11162689.958425563 1.0 2.2613832254802966 1.211108152382917 23.135853686528872 -6.60114310853552 2.186729812636285 1.847697681754252 1.2145786357276742 0.023720293269032133 0.5450553994192368 0.6374877218354105 5.762894654403604 0.2067930504015314 0.6060522881369184 2.5052835770078776e-07 6.60114310853552 -0.6331190460265779 ALAPTWEQLALGLEHSETVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALAPTWEQLALGLEHSETVK 20 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 99932000.0 38158000.0 21818000.0 39956000.0 False True 36946695.17663315 30530041.179366924 29490324.94569368 1.0 0.8263267129417187 0.798185732301837 25.138941987567687 -13.999999999999998 0.25612599232209055 2.2461066284464053 0.7875122402207124 0.9995545299595657 0.001883627511185135 14.249261617268589 0.1601422841690308 9.168855249672049 0.012559065789767131 1.0000000000000041e-14 13.999999999999998 -1.4585943882256929 ALAPTWEQLALGLEHSETVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALAPTWEQLALGLEHSETVK 20 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 189392000.0 12182000.0 162680000.0 14530000.0 False True 18480984.62349425 133648482.97535852 11658139.131274775 1.0 7.231675459837553 0.6308180742953586 24.13953828641956 -6.659170405241052 1.9755273503284188 5.014072783863827 0.6582600710494124 0.2320648089225913 2.653853384204043 0.4865120373185723 3.6490280812972995 1.085572900831305 2.942213314883726 2.1919447076231674e-07 6.659170405241052 -4.355812712814414 ALAPTWEQLALGLEHSETVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALAPTWEQLALGLEHSETVK 20 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 60781400.0 7030400.0 24099000.0 29652000.0 False True 9629728.869416235 23034226.495263994 22648808.30210937 1.0 2.391991177282269 2.3519673927727482 23.199063748051763 -10.135524668332367 4.75364950055606 0.9998933565123062 2.3719792850390102 0.9993621399433655 0.016339641643421502 1.846884225317493e-05 3.3586635014303077e-06 0.015821997466926432 0.005273596658391 7.319397471574929e-11 10.135524668332367 1.3720859285267042 ALAPTWEQLALGLEHSETVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALAPTWEQLALGLEHSETVK 20 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 60926000.0 38158000.0 10907000.0 11861000.0 False True 31730067.68602027 10848241.826130016 14341080.260932285 1.0 0.3418915438024599 0.4519713100785701 24.919347263001963 -10.127970099477494 5.588696961733579 1.0000080696664726 0.3969314269432708 0.9756205549576855 0.044939876397198895 4.518583714750536e-06 7.050629892711633e-07 0.04351342999546218 0.014504282738868448 7.447832493484525e-11 10.127970099477494 -0.6030766427232017 ALAQALK(ub)EGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALAQALKEGR 10 1 Q13363-2;Q13363;H0Y9M9;H0Y8U5;H0Y8W7;P56545;P56545-3;P56545-2 Q13363-2 CTBP1;CTBP2 C-terminal-binding protein 1;C-terminal-binding protein 2 1 2595300.0 656230.0 936870.0 1002200.0 True False 860323.8849403607 797092.647890658 898501.9577812316 1.0 0.9265029854958798 1.0443763953426883 19.714520365914943 -6.738094404718056 1.693682171219138 0.956173665771221 1.0444171895922716 0.5963713149782283 0.030881945704700608 0.32126589155411067 1.8087623346473296 0.014429048401006292 0.03548180312735095 1.827702876234886e-07 6.738094404718056 0.0882435238210506 ALAVGGLGSIIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALAVGGLGSIIR 12 0 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 0 19659000.0 6216200.0 6780700.0 6662100.0 False True 8149498.397766432 5769045.990961587 5972769.799375711 1.0 0.7079019725364611 0.7329002973990023 22.958279833413282 -9.986805816940933 5.019523559485384 1.0000021258832137 0.7204011349654688 0.9940404090810274 0.010205523402211706 2.6211522488541313e-07 5.290562075703754e-08 0.009881536663972172 0.0032938185128646032 1.030846932804816e-10 9.986805816940933 -0.27960099091774493 ALAVGGLGSIIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALAVGGLGSIIR 12 0 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 0 21150700.0 6742700.0 3119000.0 11289000.0 False True 6528656.679267382 4364432.965370127 8332072.237259393 1.0 0.6685039786561245 1.2762307234992147 22.638354746160974 -6.758605896272921 1.6179552771773935 0.8071147446358675 1.2782817668133204 0.6851765884541843 0.13940039024070372 0.28525657539753396 1.471468481472168 0.06799360709252794 0.16360962547430216 1.7433882062584426e-07 6.758605896272921 0.4711670221774529 ALAVGGLGSIIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALAVGGLGSIIR 12 0 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 0 18803600.0 3046900.0 12313000.0 3443700.0 False True 4622370.0582272755 10115648.948091894 2763051.185572668 1.0 2.188411749960873 0.5977563783874814 22.14020133319679 -6.706688318098807 1.8068630548448177 1.7330478182807836 0.6018172882729235 0.4494803357622774 0.5010546291712799 0.38174382082000613 2.427293467077284 0.22084637617496397 0.5633490969336243 1.9647698353959438e-07 6.706688318098807 -1.1312305300078602 ALAVGGLGSIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALAVGGLGSIIR 12 0 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 0 25912500.0 6216200.0 7268300.0 12428000.0 False True 8514497.126488574 6947162.472946064 9492762.362694416 1.0 0.8159216416120998 1.1148940708620902 23.021489894936174 -6.740190153873157 1.6866652103444868 0.8904940647426892 1.1150535871295528 0.6055211256813049 0.07734089975853692 0.3174678219485547 1.773526746930418 0.03627935826375196 0.08898483306843184 1.8189042852262924e-07 6.740190153873157 0.2245595223868636 ALAVGGLGSIIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALAVGGLGSIIR 12 0 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 0 14772200.0 6742700.0 3536500.0 4493000.0 False True 5606853.802257175 3517448.172559709 5432465.52671519 1.0 0.627347938186595 0.968897302891725 22.41876002159525 -10.409704111921984 8.451908391746235 1.0000020699548722 0.7981226216313975 0.31778248381072793 0.13943694424988784 5.43877855475098e-06 3.7978214902935196e-07 0.13501062564391855 0.04500308024382232 3.893102946746759e-11 10.409704111921984 -0.2018794483234747 ALAVGGLGSIIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALAVGGLGSIIR 12 0 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 0 17611200.0 3046900.0 9148100.0 5416200.0 False True 3944272.1133781006 8639000.193173815 4430507.174905038 1.0 2.190264754774964 1.1232762465545254 21.911327655289238 -6.619974043947737 2.1171171832536975 1.789795139247322 1.127367583480646 0.08262785169290188 0.5118599800092759 0.585458683952742 4.986516553841298 0.1986762045559186 0.5674669422559926 2.3989762919977124e-07 6.619974043947737 -0.6624275557666759 ALAVVYGPHEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALAVVYGPHEIR 12 0 Q9NPD3;E9PPI9 Q9NPD3 EXOSC4 Exosome complex component RRP41 0 10169100.0 3122100.0 4431000.0 2616000.0 False True 4093103.334459413 3769912.071902726 2345321.4144439204 1.0 0.9210400431780519 0.5729934533288965 21.964763658834293 -6.942651771028589 0.6344234348783048 1.0037994932499754 0.47133374913410164 0.9984909001701517 0.007206297486343168 0.08657769341774968 0.04925687820954196 0.007164641941651237 0.029623521913573706 1.1411644370897168e-07 6.942651771028589 -0.5324657441158738 ALAVVYGPHEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALAVVYGPHEIR 12 0 Q9NPD3;E9PPI9 Q9NPD3 EXOSC4 Exosome complex component RRP41 0 11561100.0 3122100.0 3952200.0 4486800.0 False True 4276424.741580066 3777578.735822332 3427110.248546617 1.0 0.8833497522106705 0.8013961324338326 22.027973720357185 -6.974916171660188 0.07651141109258092 1.3074128518161412 0.37527991901767277 0.9999999114243968 2.355587533940841e-05 0.0747376709365134 0.002215417426629825 0.010426068582549157 0.016463094215395126 1.05945820406249e-07 6.974916171660188 -0.9321329327984684 ALCDYK(ub)QDQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALCDYKQDQK 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 22511300.0 2424900.0 4683400.0 15403000.0 True False 3678750.583936239 3847610.6784287808 12358590.298625277 1.0 1.0459014794941228 3.359453166678581 21.810784435492046 -6.911190874832185 0.8875748403933084 0.9310372377151548 3.6661953136894105 0.991363496127602 0.10237450393326605 0.1036361222502019 0.13453063012799674 0.0843119693206054 0.23470844774509184 1.2268998833442105e-07 6.911190874832185 2.7351580759742555 up ALCDYK(ub)QDQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALCDYKQDQK 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 13228500.0 2424900.0 3240900.0 7562700.0 True False 3139080.8519250914 3060541.0660199397 6186366.199854935 1.0 0.9749800054187882 1.9707572030395608 21.581910757584495 -6.901139263732575 0.9540623670300447 0.9598833726854714 2.077723824500245 0.987123910272669 0.052609323164341144 0.11057078209034628 0.17273873182311172 0.04126785566404405 0.10799581402410655 1.255627261413709e-07 6.901139263732575 1.1178404518147738 ALCVLVQHNLVSYQVHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALCVLVQHNLVSYQVHK 17 0 E9PHH9;Q9BUI4 E9PHH9 POLR3C DNA-directed RNA polymerase III subunit RPC3 0 6074700.0 2278200.0 2219000.0 1577500.0 False True 3120512.1060400684 2120957.242748278 1204926.9896323176 1.0 0.6796824273307416 0.38613116972052725 21.573351377968734 -7.249607387008883 0.22873747822912985 1.1385240293046235 5.1838626388984805e-15 0.9999701187962214 0.0013703538258924381 0.09856671635606098 0.012789270860492028 0.01462606654002222 0.04256250939407332 5.628499255650482e-08 7.249607387008883 -1.1385240293046184 down ALCYLVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALCYLVLK 8 0 Q15785 Q15785 TOMM34 Mitochondrial import receptor subunit TOM34 0 13923900.0 4846800.0 3750700.0 5326400.0 False True 6354201.7364779655 3191110.1801140904 4775275.222436587 1.0 0.5022047319956311 0.7515145757842192 22.59927946352984 -10.244556974911145 4.832636446830392 1.000083384944956 0.6268596538893116 0.749171472086141 0.10178031752467036 9.146119730610774e-05 1.429730254174748e-05 0.09857030503894229 0.03284945622842102 5.6943351548319243e-11 10.244556974911145 -0.3732237310556443 ALCYLVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALCYLVLK 8 0 Q15785 Q15785 TOMM34 Mitochondrial import receptor subunit TOM34 0 16327400.0 4846800.0 4038400.0 7442200.0 False True 6638792.939845052 3859970.13479705 5684505.636920216 1.0 0.5814264987284181 0.8562559020033077 22.66248952505273 -10.185463091004923 7.102087736505802 1.0000004613590967 0.718841200365863 0.5825427012131232 0.11219863405617732 8.19696754273231e-07 9.390872415555146e-08 0.10863603997251481 0.03621195343056626 6.524344865058551e-11 10.185463091004923 -0.28115926099323374 ALDDISESIK(ub)ELQFYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALDDISESIKELQFYR 16 1 H0YG54;H0YGR4;F5GYG5;Q9Y3B8-2;Q9Y3B8-3;Q9Y3B8 H0YG54 REXO2 Oligoribonuclease, mitochondrial 1 8622600.0 2950900.0 2032300.0 3639400.0 True False 2857225.294740993 2843807.988304489 2686131.9603403127 1.0 0.9953040782394024 0.9401190607140449 21.446183367863323 -6.923696810645777 0.7968201572978348 1.0010631629927873 0.9304162903831884 0.9951478250116322 0.0018939089780174439 0.09604531215339976 0.094696069809216 0.001664599062807026 0.005177085638033175 1.1920739274048202e-07 6.923696810645777 -0.0706468726095989 ALDDISESIK(ub)ELQFYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALDDISESIKELQFYR 16 1 H0YG54;H0YGR4;F5GYG5;Q9Y3B8-2;Q9Y3B8-3;Q9Y3B8 H0YG54 REXO2 Oligoribonuclease, mitochondrial 1 48434600.0 3012800.0 7625800.0 37796000.0 True False 4570637.865183345 6264916.409352656 30325604.03342471 1.0 1.3706875482469114 6.6348734964169465 22.12396408706275 -6.921108294910751 0.8164729627152886 0.8884247498646726 7.5057720755781725 0.9944831392645994 0.19113975590531987 0.09752392509616195 0.10226981951682466 0.16566038855939252 0.5016068658061681 1.1992002353947516e-07 6.921108294910751 6.6173473257135 up ALDDISESIK(ub)ELQFYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALDDISESIKELQFYR 16 1 H0YG54;H0YGR4;F5GYG5;Q9Y3B8-2;Q9Y3B8-3;Q9Y3B8 H0YG54 REXO2 Oligoribonuclease, mitochondrial 1 10390500.0 2950900.0 3299000.0 4140600.0 True False 2453804.097035412 3281227.632199767 5006380.316028687 1.0 1.3372003234341383 2.0402526518222035 21.2265886432976 -6.959223448595555 0.4462507525695629 0.9764387905449211 2.4287112608571073 0.9997402835331084 0.006983708605669243 0.07997980282431646 0.022165857370122794 0.009346245444262446 0.058187992463965235 1.098440536031219e-07 6.959223448595555 1.4522724703121863 up ALDDISESIK(ub)ELQFYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALDDISESIKELQFYR 16 1 H0YG54;H0YGR4;F5GYG5;Q9Y3B8-2;Q9Y3B8-3;Q9Y3B8 H0YG54 REXO2 Oligoribonuclease, mitochondrial 1 45793300.0 3012800.0 7917500.0 34863000.0 True False 3900128.9911666084 7476884.164958142 28518291.724588145 1.0 1.9170863789101633 7.312140646932229 21.8950904091552 -6.936253589873942 0.6935391263595682 0.9337681255823524 8.619544007497487 0.9976308892257205 0.1355409256307199 0.08951807525329046 0.06270855018212892 0.12845653786780942 0.4725112363622655 1.158100929352403e-07 6.936253589873942 7.685775881915134 ALDDMISTLKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALDDMISTLKK 11 1 P49368;B4DUR8;P49368-2;E9PRC8;Q5SZX6;E9PM09;Q5SZW8;E9PQ35 P49368 CCT3 T-complex protein 1 subunit gamma 1 9823100.0 2249200.0 3055300.0 4518600.0 True False 2177800.3771498324 4275297.223179015 3335043.1049056845 1.0 1.9631263122354008 1.5313814525417515 21.05444028825743 -10.203216703328318 4.891694374396491 0.9999054094370469 1.7472538823900505 0.799764388995641 0.17625910089158583 0.00018185047628849272 2.9620778424255875e-05 0.17068354537449582 0.0568873801968243 6.263012762250809e-11 10.203216703328318 0.7473484729530037 ALDDMISTLKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALDDMISTLKK 11 1 P49368;B4DUR8;P49368-2;E9PRC8;Q5SZX6;E9PM09;Q5SZW8;E9PQ35 P49368 CCT3 T-complex protein 1 subunit gamma 1 34266400.0 2688300.0 4899100.0 26679000.0 True False 4078347.6410556296 4024817.3281569863 21405883.9561789 1.0 0.9868745095783968 5.248665842188542 21.959553326201625 -6.906205288520263 0.9211906457990843 0.851694087350307 5.75696256147687 0.989408994038498 0.20643664566163458 0.10698112030961818 0.1527753067551128 0.16590335073147444 0.44677673130955964 1.2410655243362402e-07 6.906205288520263 4.905268474126563 up ALDEGDIALLK(ub)TYGQSTYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALDEGDIALLKTYGQSTYSR 20 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 34035200.0 8432200.0 15109000.0 10494000.0 True False 11054695.85754096 12854796.094420737 9408181.545556001 1.0 1.1628357993812954 0.8510574751939658 23.398155997746194 -6.764764856226111 1.5943381430955446 1.0940212805346743 0.8496342491596208 0.7101848044540982 0.0685448060395155 0.27498576579210404 1.378578120385406 0.0339038806828285 0.08110414055997292 1.7188387808339022e-07 6.764764856226111 -0.24438703137505347 ALDEGDIALLK(ub)TYGQSTYSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALDEGDIALLKTYGQSTYSR 20 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 106378000.0 34797000.0 31486000.0 40095000.0 True False 33692388.2819148 44058523.99732086 29592916.675783075 1.0 1.3076699588248046 0.8783264762405634 25.005919361604203 -6.71436998237653 1.7798979087569378 1.1882984195699047 0.8792104115818112 0.4857598859706087 0.1295652125253638 0.3663310435337843 2.2649353397885 0.05787470986674839 0.14624027397053202 1.9303231433542606e-07 6.71436998237653 -0.30908800798809344 ALDEGDIALLK(ub)TYGQSTYSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALDEGDIALLKTYGQSTYSR 20 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 492590000.0 55790000.0 138240000.0 298560000.0 True False 84637508.79533294 113569991.92595008 239549485.13650364 1.0 1.3418399660200364 2.8302993382729715 26.334793828271323 -6.942929994420026 0.6317162292895042 0.9837611753996649 3.268834481098822 0.9985230522992307 0.03053695484599635 0.08645499212630026 0.048710712717045065 0.030432383059534798 0.12654817529130213 1.1404336035775372e-07 6.942929994420026 2.2850733056991572 up ALDEGDIALLK(ub)TYGQSTYSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALDEGDIALLKTYGQSTYSR 20 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 41890200.0 8432200.0 14957000.0 18501000.0 True False 11549812.211636845 14296150.28381522 14131444.84005546 1.0 1.23778205410226 1.2235216106645896 23.461366059269086 -10.03680901704364 4.516926866773589 0.9999899403478295 1.2306518324017277 0.9971412864472168 0.005821801715566118 4027122.6128562014 0.009829685449433202 430.87472032380117 0.0019929575689953643 9.187365261914785e-11 10.03680901704364 0.2306618920538982 ALDEGDIALLK(ub)TYGQSTYSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALDEGDIALLKTYGQSTYSR 20 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 98386000.0 34797000.0 34103000.0 29486000.0 True False 28935247.268474456 33919280.370084494 35651386.27213979 1.0 1.1722478144169945 1.2321092659533863 24.78632463703848 -13.999999999999998 0.14739696400361935 0.17026713052075754 1.2999813145109955 0.9995751564515103 0.002028004492280185 11.948860237590415 0.12077161510387113 2.8419595248440057 0.06102828047203707 1.0000000000000041e-14 13.999999999999998 1.129714183990238 ALDEGDIALLK(ub)TYGQSTYSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALDEGDIALLKTYGQSTYSR 20 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 430260000.0 55790000.0 139400000.0 235070000.0 True False 72221254.78531112 131642267.45755154 192289672.02188355 1.0 1.822763504301865 2.6625080468830737 26.105920150363772 -6.97087024313757 0.23647914861815977 0.6849940331346541 3.8244608231335437 0.9999883971303121 0.0023119425363279434 0.07602132105242389 0.008012799462989625 0.020583345382810786 0.08238927661949487 1.0693743351159273e-07 6.97087024313757 3.1394667899988895 ALDEYYDK(ub)HFTEFVPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALDEYYDKHFTEFVPLR 17 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 17703700.0 4201600.0 5884400.0 7617700.0 True False 5508338.2883522725 5006470.457211551 6829493.478138174 1.0 0.9088894318270263 1.239846414767148 22.393185732998482 -6.833316483467525 1.3131500470868758 0.9514184727021995 1.2493628838483826 0.912323412079466 0.041331939396240365 0.17675513171771193 0.5949261852008917 0.024705117792995945 0.056851146519844346 1.4678562167695117e-07 6.833316483467525 0.2979444111461831 ALDEYYDK(ub)HFTEFVPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALDEYYDKHFTEFVPLR 17 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 38816600.0 6392300.0 8171000.0 24253300.0 True False 6189379.9354681205 11433722.911202086 17900633.14659608 1.0 1.8473131445173305 2.8921529027515107 22.56136345391181 -6.968308160306476 0.29581732535357275 0.8095422589926093 3.962469656440811 0.9999660155589296 0.004511362165767171 0.07685557156641074 0.010984624505259876 0.017704160985288143 0.09413102264227785 1.0757016621643644e-07 6.968308160306476 3.1529273974482015 ALDEYYDK(ub)HFTEFVPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALDEYYDKHFTEFVPLR 17 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 265482000.0 10309000.0 43211000.0 211962000.0 True False 15639506.688852618 35499659.440915994 170067617.79375502 1.0 2.2698707924220596 10.874231596766045 23.898691671180956 -6.933319460640391 0.7190204983222577 0.883895909636469 12.79989624471535 0.9971514099536795 0.23410059588699833 0.09095045768316885 0.06950189831054275 0.2176560160337404 0.7648331244995278 1.165951644643636e-07 6.933319460640391 11.916000335078882 ALDEYYDK(ub)HFTEFVPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALDEYYDKHFTEFVPLR 17 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 23389800.0 4201600.0 5320700.0 13867500.0 True False 5755045.063970649 5085613.880798 10592282.110127516 1.0 0.8836792456476822 1.840521141431246 22.456395794521374 -6.8764989764240925 1.0990926906027525 0.9307550318299465 1.9039508774021232 0.9707521200401141 0.0729051509758614 0.13077870771447217 0.2913850436964744 0.05124625511674297 0.1229010467930677 1.328926689231243e-07 6.8764989764240925 0.9731958455721768 ALDEYYDK(ub)HFTEFVPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALDEYYDKHFTEFVPLR 17 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 34378800.0 6392300.0 10856400.0 17130100.0 True False 5315480.6769051775 10797914.418373333 20711924.709366497 1.0 2.031408836700011 3.896529019352124 22.341768729346086 -6.96196670241165 0.40677515741746695 0.9048278673549816 5.091963540743053 0.9998363152537155 0.015336338157108139 0.07900600624697253 0.018590080805548668 0.02400044187028285 0.15588994826359395 1.0915240209664617e-07 6.96196670241165 4.187135673388071 ALDEYYDK(ub)HFTEFVPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALDEYYDKHFTEFVPLR 17 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 197676900.0 10309000.0 21670900.0 165697000.0 True False 13345203.720770253 20464895.3647479 135541846.19479346 1.0 1.5335019077225984 10.156596259661319 23.669817993273405 -6.919539326823498 0.8281332079336976 0.806557150938175 11.532532762264598 0.9940520132852434 0.32363739215971427 0.09844380961914634 0.1070236032641179 0.27816801397048163 0.8296149881096421 1.2035404002324246e-07 6.919539326823498 10.725975611326422 up ALDFTDSQENEEK(ub)ASEYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALDFTDSQENEEKASEYR 18 1 O94782;C9JC88;C9JWX4 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 11955300.0 975300.0 0.0 10980000.0 True False 1262545.0760371727 0.0 8981752.66431396 1.0 0.0 7.114005539117492 20.267903465952482 -6.87130568324386 1.127103134760145 0.4296559685906256 7.541220791794819 0.965972153431308 0.5800519881083919 0.1356123214339504 0.3211777101210361 0.39906076966003196 0.9470388838445516 1.3449133878311517e-07 6.87130568324386 7.111564823204193 up ALDK(ub)LDGTEINGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALDKLDGTEINGR 13 1 A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247 A0A590UJK4 SRSF6 Serine/arginine-rich splicing factor 6 1 12661400.0 4736900.0 3928600.0 3995900.0 True False 4586529.702347964 5497310.467378355 2949253.915569561 1.0 1.198577317522688 0.6430251425298219 22.1289715519838 -6.810046635295964 1.4142509355565627 1.1082193303192804 0.6332881024728167 0.8599599977664967 0.08601636249921187 0.206743738013594 0.8149701335904376 0.047822712859316815 0.1106258728140858 1.548650313222449e-07 6.810046635295964 -0.4749312278464637 ALDK(ub)LDGTEINGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALDKLDGTEINGR 13 1 A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247 A0A590UJK4 SRSF6 Serine/arginine-rich splicing factor 6 1 9672100.0 5806200.0 3865900.0 0.0 True False 8808429.890078187 3175999.9405854396 0.0 1.0 0.36056368504026864 0.0 23.070453449801096 -8.449228516277625 0.5177268254090563 1.04613619636697 3.3564385472928913e-19 0.9931178517704168 0.034303926219533834 0.20095692224916192 0.18232656834298003 0.07372262553591247 0.06788809277729259 3.5544424235306062e-09 8.449228516277625 -1.04613619636697 ALDK(ub)LDGTEINGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALDKLDGTEINGR 13 1 A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247 A0A590UJK4 SRSF6 Serine/arginine-rich splicing factor 6 1 7942700.0 3308300.0 2089900.0 2544500.0 True False 4531467.913445861 1997561.3076248874 1943541.5056224628 1.0 0.44081991658766556 0.42889887840881497 22.111547038668963 ALDLDSSCK(ub)EAADGYQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALDLDSSCKEAADGYQR 17 1 P31948;P31948-2;P31948-3;H0YGI8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 9979900.0 3921600.0 4203900.0 1854400.0 True False 5141255.5768284155 3576694.5066738566 1662524.4766608612 1.0 0.6956850234783077 0.3233693505053204 22.293689300972435 -7.109362486104391 0.31547854500760136 1.0590257035109263 3.866890029646473e-14 0.9999408064550719 0.0021288323273088803 0.07732476332369072 0.013773780157874081 0.007069715755142954 0.03408303816134394 7.773874297980513e-08 7.109362486104391 -1.0590257035108877 down ALDLDSSCK(ub)EAADGYQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALDLDSSCKEAADGYQR 17 1 P31948;P31948-2;P31948-3;H0YGI8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 26231000.0 10801000.0 9381300.0 6048700.0 True False 16385906.658870582 7707133.7185685495 4853171.793760608 1.0 0.47035137444752007 0.296179631362255 23.96595216596422 -13.999999999999998 0.15546684964332355 3.585027471822208 0.11609793159877628 0.9995490304645742 0.0063559536712236835 11.98251531833389 0.12443344394621134 9.345516468159447 0.16324537096601224 1.0000000000000041e-14 13.999999999999998 -3.468929540223432 ALDLDSSCK(ub)EAADGYQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALDLDSSCKEAADGYQR 17 1 P31948;P31948-2;P31948-3;H0YGI8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 11654900.0 3921600.0 5697700.0 2035600.0 True False 5371521.497255164 5445956.7742257165 1554833.2044979671 1.0 1.013857391617736 0.2894586208567691 22.356899362495326 -6.902540011710375 0.9450690638431055 1.028054991655185 0.20937312793908036 0.9877882088342743 0.03738074555587705 0.10955976063651071 0.1670622647425131 0.029517499708787073 0.07782612560635346 1.2515839588293088e-07 6.902540011710375 -0.8186818637161047 down ALDLDSSCK(ub)EAADGYQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALDLDSSCKEAADGYQR 17 1 P31948;P31948-2;P31948-3;H0YGI8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 26000300.0 10801000.0 9048000.0 6151300.0 True False 13982107.419540135 8544470.846168773 5031826.517667981 1.0 0.6111003577492038 0.3598761164312007 23.73707848805667 -8.440752891950453 0.17727332359098122 1.3513388146242713 4.271155576359321e-07 0.9998250642011446 0.00348297095732222 0.13138484087050256 0.042764580722884735 0.1481759258204308 0.1320883277714022 3.624491687349707e-09 8.440752891950453 -1.3513383875087137 down ALDLSLYLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALDLSLYLK 9 0 Q9NZ08;Q9NZ08-2 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 30108300.0 7533800.0 12860000.0 9714500.0 False True 11429325.394556 10565032.524361387 7794424.816983402 1.0 0.9243793627044434 0.6819671807310719 23.4462369165259 -6.949952134727054 0.5593772706901926 1.0031808211088975 0.5915930073958439 0.999197461112981 0.003843057596975626 0.08350513987439902 0.03604319230684312 0.004122642712741048 0.02014826939980016 1.1221421231061268e-07 6.949952134727054 -0.41158781371305364 ALDLSLYLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALDLSLYLK 9 0 Q9NZ08;Q9NZ08-2 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 22534000.0 7533800.0 7902300.0 7097900.0 False True 9752652.613399835 7462530.058320013 5806155.030604191 1.0 0.7651795213198441 0.5953411098255175 23.21736323861835 -7.2065620583158365 0.10617969966813205 1.395538166399264 6.475503409876737e-10 0.9999991964434106 0.00014861162615630147 0.09313321304160407 0.004729543626874745 0.022633388582502873 0.03811564524061497 6.214954330950409e-08 7.2065620583158365 -1.3955381657517139 ALDLVAAK(ub)CYYYHAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALDLVAAKCYYYHAR 15 1 O43242;O43242-2;H0YGV8 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 25986200.0 3279300.0 5272900.0 17434000.0 True False 4245118.49466697 4979458.479748383 14261190.88794625 1.0 1.1729845670984083 3.3594329359385857 22.017373393840412 -6.922659300598088 0.8047679777677444 0.9562238705447138 3.734513025331951 0.9948881302631869 0.07677379232518358 0.09663208386223983 0.0976937682711774 0.06709770232728002 0.20639319677062767 1.194925142933309e-07 6.922659300598088 2.7782891547872373 up ALDTMNFDVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALDTMNFDVIK 11 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YBN4;E5RGH3;E5RJB9;E5RH24;B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 22645500.0 3059800.0 9744100.0 9841600.0 False True 4011427.431145347 8290318.262204303 8823285.639293317 1.0 2.066675367934362 2.199537643579927 21.93568426769782 -10.791519657627719 0.39666522270745846 5.251559221676478e-13 2.211213891052168 0.9994279749803093 0.012841022284225175 2.4260258735563123 0.1921991791048605 2.336375365375316 0.034203513201494194 1.616145072293926e-11 10.791519657627719 2.2112138910516426 ALDTMNFDVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALDTMNFDVIK 11 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YBN4;E5RGH3;E5RJB9;E5RH24;B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 9854800.0 0.0 0.0 9854800.0 False True 0.0 0.0 7273532.242337125 0.0 ALDTMNFDVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALDTMNFDVIK 11 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YBN4;E5RGH3;E5RJB9;E5RH24;B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 23731800.0 3059800.0 10471000.0 10201000.0 False True 4191090.7479858627 10008356.597033445 7791733.896189713 1.0 2.388007609198923 1.8591183929706683 21.99889432922071 -10.551666855161768 7.125222841967755 0.9992820010863173 2.1235630010847943 0.8574957532695859 0.2159181183699573 0.002463940679099167 0.00015503579612093064 0.20916628350191868 0.06968727304927388 2.8075864958288977e-11 10.551666855161768 1.124280999998477 ALDTMNFDVIK(ub)GK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALDTMNFDVIKGK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YBN4;E5RGH3;E5RJB9;E5RH24;B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 29968600.0 9638700.0 11209000.0 9120900.0 True False 12636429.041303568 9536660.892339796 8177156.76185076 1.0 0.7546958765936297 0.647109775643326 23.59108549068032 -13.999999999999991 0.1119758451062993 2.179786494473408 0.4552446200466748 0.9997330396819967 0.00241289996307369 12.001397242873633 0.1018607729897702 3.189727770556539 0.1703424420302249 1.0000000000000205e-14 13.999999999999991 -1.7245418744267331 ALDTMNFDVIK(ub)GK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALDTMNFDVIKGK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YBN4;E5RGH3;E5RJB9;E5RH24;B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 38034000.0 12849000.0 14437000.0 10748000.0 True False 12441115.528187022 20201769.387960397 7932776.366911497 1.0 1.6237908362952316 0.6376258100761724 23.56861251421619 -6.735793219083868 1.7024070068900268 1.372956842266613 0.6375958046665442 0.5857850358507972 0.26212864952555687 0.32547735336696965 1.850515541952704 0.12190187922803222 0.30049307626673305 1.8374129837577333e-07 6.735793219083868 -0.7353610376000688 ALDTMNFDVIK(ub)GK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALDTMNFDVIKGK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YBN4;E5RGH3;E5RJB9;E5RH24;B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 30582900.0 9646900.0 10201000.0 10735000.0 True False 14635052.582858864 8380551.849223216 8613222.54468236 1.0 0.5726355817155615 0.58853376138672 23.802924593483546 -9.859148544487855 6.6960576379811245 1.0000000096257862 0.5805846715638584 0.9989235346461837 0.006490404672298703 9.355658660666393e-10 1.608259787797116e-10 0.006284307441927963 0.002094769100487631 1.3830932299360542e-10 9.859148544487855 -0.41941533806192777 ALDTMNFDVIK(ub)GK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALDTMNFDVIKGK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YBN4;E5RGH3;E5RJB9;E5RH24;B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 29698400.0 9638700.0 11026000.0 9033700.0 True False 13202387.866073381 10538834.861893892 6900126.114891575 1.0 0.7982521774697962 0.5226422814484234 23.654295552203212 -6.966764387500883 0.32635588096919005 1.0350372793858875 0.2768835776993084 0.9999450305523411 0.0014506132868785742 0.07736723895969666 0.012775613835563415 0.00407547531389297 0.024111246315504913 1.0795322288718398e-07 6.966764387500883 -0.7581537016865791 ALDTMNFDVIK(ub)GK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALDTMNFDVIKGK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YBN4;E5RGH3;E5RJB9;E5RH24;B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 34991100.0 12849000.0 15798000.0 6344100.0 True False 10684512.807214092 15712893.038342511 7670621.97819582 1.0 1.4706232583420462 0.717919676507541 23.349017789650468 -6.737653342414506 1.6952408534894907 1.2807800266956384 0.7176983034456065 0.5943531407788403 0.19775029563509602 0.3220935878780282 1.8165755038688993 0.09231560751352472 0.22712450204606147 1.8295600039664108e-07 6.737653342414506 -0.5630817232500319 ALDTMNFDVIK(ub)GKPIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALDTMNFDVIKGKPIR 16 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 53595000.0 20168000.0 20972300.0 12454700.0 True False 26440443.30718982 17843314.5893851 11166007.11791848 1.0 0.6748492974220691 0.42230786330583814 24.6562430298515 -7.544574012437607 0.18190488262381885 1.2349740964447107 1.193265509676888e-12 0.9999619308961194 0.0014589628252409997 0.13196610550963567 0.017905905055879058 0.0380692718768402 0.07043327518019042 2.853816125182531e-08 7.544574012437607 -1.2349740964435174 down ALDTMNFDVIK(ub)GKPIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALDTMNFDVIKGKPIR 16 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 93791000.0 36508000.0 34023000.0 23260000.0 True False 35349073.523468874 47608561.327601165 17167508.214957327 1.0 1.3468121391072103 0.4856565251578521 25.075169067630572 -6.797429664043506 1.4667426085187516 1.1919802692824844 0.4745570130407676 0.8244352228516679 0.14823372123373385 0.2244513502105977 0.9536050586510346 0.07952237356097946 0.1852074871045926 1.5943010640760915e-07 6.797429664043506 -0.7174232562417168 down ALDTMNFDVIK(ub)GKPIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALDTMNFDVIKGKPIR 16 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 87533200.0 30878200.0 34450000.0 22205000.0 True False 46844486.89879991 28302128.340921473 17816172.01720278 1.0 0.6041720213963222 0.3803259080559852 25.48137593212209 -9.532061458655777 0.14307557305933483 1.6160639087958366 2.528897927727744e-21 0.9998169581227719 0.003466309311652399 0.9824450668218807 0.057007765300180424 0.43606217554304466 0.1942478555983335 2.937233963454892e-10 9.532061458655777 -1.6160639087958366 ALDTMNFDVIK(ub)GKPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALDTMNFDVIKGKPIR 16 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 52456100.0 20168000.0 20699100.0 11589000.0 True False 27624654.619706817 19784545.319229804 8851916.882947033 1.0 0.7161915901426672 0.3204353866068708 24.71945309137439 -7.018369235158 0.34143822607499386 1.0437321976767568 3.201182020555771e-11 0.9999367908192122 0.00221563992724571 0.07304737692898818 0.013529464239656865 0.005625097088007994 0.03248258719749235 9.58585300185023e-08 7.018369235158 -1.0437321976447451 down ALDTMNFDVIK(ub)GKPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALDTMNFDVIKGKPIR 16 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 90830900.0 36508000.0 41730000.0 12592900.0 True False 30358019.5786265 41505192.20724356 15226017.167009033 1.0 1.3671903761622581 0.5015484336049667 24.85557434306485 -6.791463648419881 1.490566790715763 1.20483139019972 0.49197800545796 0.8060108959055364 0.1562461336117406 0.2331737609843237 1.023426354001036 0.08250298632636589 0.19294854799204694 1.6163535134466663e-07 6.791463648419881 -0.7128533847417601 ALDTMNFDVIK(ub)GKPIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALDTMNFDVIKGKPIR 16 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 95131200.0 30878200.0 52729000.0 11524000.0 True False 39972438.6003189 49794584.79748381 9426750.246225338 1.0 1.2457229666514904 0.23583125214057196 25.25250225421454 -6.842414494167256 1.2712406511954626 1.1307019896849184 0.2010184941916499 0.9285070806550999 0.11497805744296262 0.166000967726719 0.5200794307760412 0.07089326073615354 0.16343563821683577 1.4374260323405824e-07 6.842414494167256 -0.9296834954932685 down ALDTMNFDVIK(ub)GKPVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALDTMNFDVIKGKPVR 16 2 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;E5RGH3;E5RJB9;E5RH24 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 42452100.0 5284600.0 33168400.0 3999100.0 True False 6928161.776139193 28219804.009410564 3585311.4940759484 1.0 4.073202231882122 0.5174982354517 22.724041187453015 -6.678083214170694 1.9082480924778615 2.947851126680672 0.5311246188471264 0.3153478869536642 1.3030612006012958 0.4429292217114506 3.1165478428589775 0.5482046338847255 1.4496517666999924 2.0985377490884366e-07 6.678083214170694 -2.4167265078335456 ALDTMNFDVIK(ub)GKPVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALDTMNFDVIKGKPVR 16 2 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;E5RGH3;E5RJB9;E5RH24 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 167949000.0 60826000.0 76244000.0 30879000.0 True False 78740456.05971195 72000954.3761376 25259338.845296048 1.0 0.9144086531774274 0.32079238690389233 26.23060173273058 -6.932852962416803 0.7229981786730261 1.0081413053758197 0.189575850854352 0.9970696938175525 0.01634987747872206 0.09118356818516354 0.07062193287850638 0.015156740788544702 0.052894812526979855 1.167204726645897e-07 6.932852962416803 -0.8185654545214677 down ALDVMVSTFHK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ALDVMVSTFHK 11 0 P26447 P26447 S100A4 Protein S100-A4 0 637487800.0 213768200.0 178413200.0 245306400.0 False True 280252180.3341934 151794646.00920653 219924446.87314463 1.0 0.5416359145830565 0.7847376837921135 28.062150356197726 -10.054143293388192 5.0766755122285705 1.0000053159577897 0.6631867991861095 0.7190549544385562 0.0992458816934679 5.971461923025278e-06 1.1127549900736029e-06 0.09609592777714755 0.032031470580803724 8.827885804893688e-11 10.054143293388192 -0.3368185167716803 ALDVMVSTFHK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ALDVMVSTFHK 11 0 P26447 P26447 S100A4 Protein S100-A4 0 447395900.0 140601000.0 95892900.0 210902000.0 False True 136137698.21609637 134183435.04486722 155660439.27562058 1.0 0.9856449521562567 1.1434043715689612 27.020491381403673 -6.884666432472417 1.053395401634804 0.9904082852782231 1.1556370527503712 0.9772600789702456 0.010740783345137636 0.12357837770939518 0.2479695155343397 0.007818302464830045 0.019152567848258768 1.3041680831393795e-07 6.884666432472417 0.1652287674721481 ALDVMVSTFHK ddPTM_RPMI8226_Bortezomib_8h_R1 2 ALDVMVSTFHK 11 0 P26447 P26447 S100A4 Protein S100-A4 0 1160689000.0 299515000.0 591736000.0 269438000.0 False True 454386152.4795511 486136087.5455295 216183461.20112935 1.0 1.0698743456258986 0.47577035528356765 28.759343628154763 -6.877568960621527 1.0932166590275723 1.0420642353382963 0.4355728566039556 0.9716733349955113 0.0446232508526305 0.12980771824308338 0.2854555934560776 0.03150787209584767 0.07574832285563479 1.3256566030855873e-07 6.877568960621527 -0.6064913787343407 down ALDVMVSTFHK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ALDVMVSTFHK 11 0 P26447 P26447 S100A4 Protein S100-A4 0 691621200.0 213768200.0 206612200.0 271240800.0 False True 292804080.4083899 197483389.82882205 207179309.41962692 1.0 0.6744557301024668 0.7075697481082318 28.125360417720618 -9.513342640576933 6.398843125039607 0.9999999998835067 0.6910127403153151 0.9914595850460469 0.013518741267378183 17727242.111975867 0.3973419613469184 0.030697516311759494 0.004627824709178255 3.066601610527367e-10 9.513342640576933 -0.3089872595681916 ALDVMVSTFHK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ALDVMVSTFHK 11 0 P26447 P26447 S100A4 Protein S100-A4 0 273544800.0 140601000.0 80590700.0 52353100.0 False True 116915961.18041152 80156541.90309846 63299891.15661536 1.0 0.6855910954656562 0.541413597574912 26.80089665683795 -13.99999999999972 0.10474822442205871 2.5334119710092775 0.25574397389812037 0.9997697537074912 0.002905311800054246 12.046117854752936 0.09731159818813546 3.948320933764728 0.2541805336969563 1.0000000000006462e-14 13.99999999999972 -2.2776679971111573 ALDVMVSTFHK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ALDVMVSTFHK 11 0 P26447 P26447 S100A4 Protein S100-A4 0 875161000.0 299515000.0 391495000.0 184151000.0 False True 387728071.82331 369707959.0982366 150637407.5488235 1.0 0.9535238378786118 0.3885130288360185 28.530469950247213 -6.923207193535605 0.8005818598381078 1.0110852531944854 0.29032196181453607 0.9950263841671783 0.01960221714103971 0.09632137317480366 0.09610421786075449 0.017182758976959766 0.053160396539356315 1.19341861158599e-07 6.923207193535605 -0.7207632913799493 down ALDVSASDDEIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALDVSASDDEIAR 13 0 C9JIF9;P13798;H7C393;H7C1U0;C9JLK2 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 9340000.0 1316600.0 3233400.0 4790000.0 False True 1726075.349972535 2750989.323694485 4294376.748924463 1.0 1.5937828691767473 2.4879428056213158 20.719064014524083 -6.96519221091734 0.3547377523684355 0.9181669863970017 3.1939517621066575 0.9999170533019498 0.005569803645082028 0.07789579407366796 0.014630275603597538 0.01213378975270728 0.0766201000295712 1.0834472936308577e-07 6.96519221091734 2.275784775709656 ALDVSASDDEIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALDVSASDDEIAR 13 0 C9JIF9;P13798;H7C393;H7C1U0;C9JLK2 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 6411910.0 1912900.0 721510.0 3777500.0 False True 1852176.0365685206 1009612.7056249441 2788059.4274291215 1.0 0.5450954367682177 1.5052885753745568 20.820789792660513 -6.777878362369768 1.5441880181972798 0.7417124048172924 1.51238883427635 0.759798365506611 0.19220742385612138 0.25388218775821203 1.1956115889375654 0.09805253263461765 0.23177160559879154 1.667714242207808e-07 6.777878362369768 0.7706764294590577 ALDVSASDDEIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALDVSASDDEIAR 13 0 C9JIF9;P13798;H7C393;H7C1U0;C9JLK2 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 6979600.0 1316600.0 3330900.0 2332100.0 False True 1803382.5997771702 3183729.8241866753 1781306.0111071512 1.0 1.7654211727339855 0.9877582335147589 20.782274076046974 -10.19903211008975 4.25061066088292 0.9998535551245085 1.376589702678293 0.23819666753646096 0.31747956556438184 45742352.66082672 54877832.945853695 51398.51281012075 0.1086817007986395 6.323650949667622e-11 10.19903211008975 0.3767361475537845 ALDVTDK(ub)EGEEREDADVSVTQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALDVTDKEGEEREDADVSVTQR 22 2 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 9571300.0 2132100.0 1644300.0 5794900.0 True False 2064417.6525525346 2300877.5649112226 4277041.846726415 1.0 1.1145407335896003 2.071790967994338 20.977303441399172 -6.929291534602735 0.7525821448711075 0.9850547285723651 2.264812288258339 0.9963972824958434 0.028842691478036833 0.09300700594127252 0.07949359781401735 0.026167363546206326 0.0869542270391457 1.1768157316465584e-07 6.929291534602735 1.279757559685974 up ALDVTDK(ub)EGEEREDADVSVTQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALDVTDKEGEEREDADVSVTQR 22 2 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 27153000.0 6046700.0 6349300.0 14757000.0 True False 9173285.97298332 5216217.807692671 11840272.48177713 1.0 0.5686313304801793 1.2907340419396582 23.12900718512358 -6.744902699808695 1.6686568628499543 0.744804120799634 1.2916332931793313 0.6267580080332068 0.18123700512451993 0.3090287195137186 1.6912624474818712 0.08585919384885032 0.2095749611552151 1.7992739828628267e-07 6.744902699808695 0.5468291723796973 ALDVTDK(ub)EGEEREDADVSVTQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALDVTDKEGEEREDADVSVTQR 22 2 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 7274700.0 2016200.0 1900300.0 3358200.0 True False 2761643.625756289 1816338.4625482422 2565062.3243000004 1.0 0.6577019734220159 0.9288172812658064 21.39709572942483 -9.87444082768943 6.101278491461306 1.000000028059202 0.7932596273438245 0.4367214136481854 0.11068236094612038 4.2290563463262285e-08 7.721211619012333e-09 0.1071677503364344 0.03572257838855823 1.3352395025905026e-10 9.87444082768943 -0.20674040071537758 ALDVTDK(ub)EGEEREDADVSVTQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALDVTDKEGEEREDADVSVTQR 22 2 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 9960500.0 2132100.0 4102400.0 3726000.0 True False 1772935.6180450728 4080299.556937354 4505089.372922498 1.0 2.301436958797464 2.5410338238283203 20.75770871683345 -10.444279646634573 0.35652983783758374 6.267121918378057e-14 2.5825677323458978 0.9991275156556305 0.019999469673539706 1.9232688621223588 0.16881598467458897 1.8400713486208393 0.06952967847948535 3.595177634631239e-11 10.444279646634573 2.582567732345835 ALDVTDK(ub)EGEEREDADVSVTQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALDVTDKEGEEREDADVSVTQR 22 2 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 34544100.0 6046700.0 5481600.0 23015800.0 True False 7827572.348276401 5176544.141286334 18827160.56205077 1.0 0.6613217880287223 2.4052362245104555 22.90013350721603 -6.856333641464862 1.20409067446902 0.8177503994845614 2.4839720449579503 0.9490305386674489 0.17045866669315882 0.15062569195930436 0.41706827808685865 0.11056629413570539 0.25712613462493883 1.3920869381475748e-07 6.856333641464862 1.666221645473389 up ALDYCHSMGIMHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALDYCHSMGIMHR 13 0 P68400;Q8NEV1;E7EU96;A0A2R8YD58;A0A2R8Y5A0;A0A2R8Y4D6;A0A2R8YFU2;A0A2R8Y4H0;P68400-2;A0A2R8YDY7;V9GYW6 P68400 CSNK2A1;CSNK2A3 Casein kinase II subunit alpha;Casein kinase II subunit alpha 3 0 22750200.0 6370900.0 7403400.0 8975900.0 False True 8352311.595883359 6298841.578227169 8047159.9709125385 1.0 0.7541435093647256 0.9634650094805823 22.993744104202545 -10.12041990907803 6.461945723849314 1.0000002924305833 0.8588042595625324 0.3775955881856672 0.08545514457963094 3.600018381947e-07 4.903606153931646e-08 0.08274175932934995 0.027580529317054635 7.578444787506962e-11 10.12041990907803 -0.14119603286805094 ALDYCHSMGIMHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALDYCHSMGIMHR 13 0 P68400;Q8NEV1;E7EU96;A0A2R8YD58;A0A2R8Y5A0;A0A2R8Y4D6;A0A2R8YFU2;A0A2R8Y4H0;P68400-2;A0A2R8YDY7;V9GYW6 P68400 CSNK2A1;CSNK2A3 Casein kinase II subunit alpha;Casein kinase II subunit alpha 3 0 17415400.0 6370900.0 3708200.0 7336300.0 False True 8726393.897098877 3544359.4626224306 5603617.035841251 1.0 0.4061654223287774 0.642145782314983 23.056954165725436 -10.265612241171507 5.61281078139661 1.0000359323341779 0.5241556023218797 0.844272380620386 0.09633857854745272 4.33211706584432e-05 5.6682824325498305e-06 0.09328645110601454 0.031093142525959534 5.424850307486577e-11 10.265612241171507 -0.4758803300122981 ALEAVFGK(ub)YGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALEAVFGKYGR 11 1 P38159;P38159-2;H3BT71;H0Y6E7;H3BR27;P38159-3;H3BNC1 P38159 RBMX RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed 1 10870500.0 2453700.0 3566700.0 4850100.0 True False 3722442.2894982705 2930194.5182457045 3891475.6091256486 1.0 0.7871698982445879 1.0454092519054636 21.82781805163053 -6.687714904333205 1.8740589588695789 0.8662914328006884 1.0445057390468795 0.36002979005954405 0.09005318230238162 0.4215627189679135 2.8686211558295645 0.03846306264666832 0.10046757765901397 2.052509120718896e-07 6.687714904333205 0.17821430624619106 ALECFCQAASEVGK(ub)EEFLDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALECFCQAASEVGKEEFLDR 20 1 Q12769;G3V198;E9PR16 Q12769 NUP160 Nuclear pore complex protein Nup160 1 44859200.0 4809200.0 12424000.0 27626000.0 True False 7295907.999614887 10206840.13084493 22165708.99109405 1.0 1.3989814744626297 3.038101493640553 22.798656106757722 -6.944261319564794 0.6186493551426726 0.9820425036519949 3.541677303567736 0.998670471463211 0.032156523756336555 0.08587522572776021 0.04615273983483567 0.03242409239707285 0.13864900311275705 1.1369429694021733e-07 6.944261319564794 2.5596347999157407 up ALECFCQAASEVGK(ub)EEFLDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALECFCQAASEVGKEEFLDR 20 1 Q12769;G3V198;E9PR16 Q12769 NUP160 Nuclear pore complex protein Nup160 1 34448300.0 4809200.0 8697100.0 20942000.0 True False 6225604.203504529 8213098.739634665 17130770.883065842 1.0 1.3192452445035505 2.75166398683401 22.56978242885017 -6.942246191540075 0.638323673330642 0.9843355217385943 3.1648824033496297 0.9984435698594728 0.030051406452911784 0.08675666231109114 0.05005395761410759 0.0297770360347581 0.12211748934790291 1.1422306469790369e-07 6.942246191540075 2.1805468816110354 up ALEEAMEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALEEAMEQK 9 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 7316490.0 2267300.0 591390.0 4457800.0 False True 2195325.802557273 827535.1110581093 3290168.448866591 1.0 0.37695321127011633 1.4987153364817043 21.06600363156942 -6.755973113450365 1.627877261171848 0.6362890395027551 1.5019829288779585 0.6742200336305167 0.2619236454577772 0.28973392724144914 1.5123011375097808 0.12701615503891373 0.30643563097956183 1.7539890854338543e-07 6.755973113450365 0.8656938893752034 ALEEGLTPQEICDK(ub)YHIIHADIYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALEEGLTPQEICDKYHIIHADIYR 24 1 P56192;P56192-2;H0YHV5 P56192 MARS Methionine--tRNA ligase, cytoplasmic 1 13388100.0 3821500.0 4961400.0 4605200.0 True False 4947007.08302682 4685293.728578893 3767100.853342316 1.0 0.9470966283137403 0.761490895427912 22.238124534444392 -6.9478895050438805 0.5815559608022095 1.002205935291999 0.6971767199256163 0.9990250513909703 0.0031933322755124073 0.08434452619658703 0.039556784925544895 0.003340172160417126 0.015511331186090202 1.1274842787905859e-07 6.9478895050438805 -0.3050292153663827 ALEENNNFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALEENNNFSK 10 0 E5RGX5;Q93045;Q93045-2 E5RGX5 STMN2 Stathmin;Stathmin-2 0 41331800.0 12347000.0 4928800.0 24056000.0 False True 11955051.24340609 6896895.543352457 17755011.935469195 1.0 0.5769022150496007 1.4851472882863737 23.511116978154796 -6.780022367112181 1.5356765137583581 0.7604391940461073 1.4923606078014104 0.7675038378400743 0.1789257684790937 0.25054009949981076 1.1670271338442941 0.09176576209095369 0.21653430731524353 1.6595014372964198e-07 6.780022367112181 0.7319214137553032 ALEHSSCK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALEHSSCKLR 10 1 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 27244800.0 8031400.0 11545000.0 7668400.0 True False 10529243.176188225 9822531.002057541 6874947.528486922 1.0 0.9328810093655253 0.6529384318936184 23.327898405874326 -6.943915133281998 0.6220789137398101 1.0030599694566984 0.5678757390271141 0.9986329981242101 0.0055572247746177705 0.08602516999305225 0.0468116701280939 0.005585978531786045 0.023710312410191243 1.1378496145241781e-07 6.943915133281998 -0.4351842304295843 ALEHSSCK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALEHSSCKLR 10 1 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 15230100.0 6098500.0 5499900.0 3631700.0 True False 5904906.455650129 7696038.751599599 2680448.8213353613 1.0 1.3033294954631531 0.4539358652787065 22.493482774240658 -6.810151078561666 1.4139902131099085 1.1652799402825587 0.4390370884187242 0.8602042896067981 0.13140518711772364 0.20659154719092426 0.8140780909649247 0.0730741774178563 0.16901678254034597 1.5482779238522826e-07 6.810151078561666 -0.7262428518638344 down ALEHSSCK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALEHSSCKLR 10 1 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 20384200.0 3774400.0 3965800.0 12644000.0 True False 5726040.745601436 3258072.005063177 10144907.857937938 1.0 0.5689921098738121 1.7717142277988391 22.449106505687983 -6.809789704034821 1.4153781781374242 0.7650458436638121 1.7926621381996708 0.8592870590353933 0.18663317741298102 0.20708764653012807 0.8176835560128434 0.1036832675315152 0.23986797745395202 1.549566775247398e-07 6.809789704034821 1.0276162945358587 ALEHSSCK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALEHSSCKLR 10 1 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 28572400.0 8031400.0 10204000.0 10337000.0 True False 11000825.620424096 9753153.53988437 7895613.497197638 1.0 0.8865837780190514 0.7177291750301604 23.391108467397217 -6.965382139602585 0.3514447248612302 1.016048908693191 0.5825537417562322 0.9999207911052203 0.001032154704442246 0.07783165465723195 0.0144048933578796 0.002309415664600283 0.014499699417502072 1.0829735765124726e-07 6.965382139602585 -0.4334951669369588 ALEHSSCK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALEHSSCKLR 10 1 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 17040300.0 6098500.0 3306900.0 7634900.0 True False 5071172.959358324 3289085.073331744 9231322.290210936 1.0 0.6485846765021253 1.8203524833787197 22.273888049674934 -6.826300320039765 1.3442874507972908 0.8116911878152453 1.8495819339470745 0.8982815798097583 0.15658835018931047 0.18542351470423798 0.6566053730993896 0.09148994418355434 0.21061263835637398 1.4917624805014441e-07 6.826300320039765 1.0378907461318292 ALEHSSCK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALEHSSCKLR 10 1 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 9786500.0 3774400.0 1958800.0 4053300.0 True False 4886035.204547012 1849791.0580764133 3315640.990370107 1.0 0.3785873373067333 0.6785953951548539 22.220232827780432 -10.51146004460671 6.340241234367247 1.0003766486043082 0.5285913662308482 0.7670117350039845 0.12247777674187901 0.0006525817527544217 5.028386446408922e-05 0.11867974185509227 0.0395295324668173 3.0799236835815504e-11 10.51146004460671 -0.47178528237345996 ALEIIPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALEIIPR 7 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 5452120.0 2204200.0 734920.0 2513000.0 False True 2134228.87751808 1028377.3885571699 1854769.9116159836 1.0 0.48184962699646444 0.8690585771535981 21.025283470300995 -9.756968317896556 6.06069045545053 1.0000000094982988 0.6754541020741988 0.4836575899710276 0.15807739195693385 2.0219794979147342e-08 4.327641423130239e-09 0.15305778003507275 0.051019258871322554 1.7499743458902024e-10 9.756968317896556 -0.32454590742410006 ALEK(ub)IDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALEKIDLK 8 1 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 1 5335000.0 1308000.0 1555400.0 2471600.0 True False 1266478.2559630005 2176479.3313038466 1824213.8135893615 1.0 1.718528779358239 1.4403830504000812 20.272390877102072 -10.24927534204365 5.091414255180191 0.9999127554537506 1.579455914879332 0.8526540757458378 0.11355251834782855 0.0001124790611778482 1.6584882847824264e-05 0.10996319192691792 0.03664891770663444 5.632804236602614e-11 10.24927534204365 0.5795431594255813 ALEK(ub)IDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALEKIDLK 8 1 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 1 4942010.0 1308000.0 2686100.0 947910.0 True False 1087659.9542249206 2671629.446150894 1146113.5983593557 1.0 2.4563094704123114 1.0537425726739107 20.05279615253635 -6.637438850061607 2.054107033578393 1.9542175926242737 1.059590445959528 0.14469502439522386 0.6235190233305972 0.5398737207745187 4.350532193358459 0.24748936756719866 0.6902875688680045 2.3044174219539606e-07 6.637438850061607 -0.8946271466647457 ALEKEEEEEK(ub)QK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALEKEEEEEKQK 12 2 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 3209060.0 1078600.0 758060.0 1372400.0 True False 1044360.4333957895 1060757.311230676 1012927.2688825212 1.0 1.0157004012317579 0.9699019959890076 19.994188275227188 -6.814169520929773 1.3969558099463377 1.0085153526073867 0.9690221763512873 0.8704346833852706 0.006840015391308336 0.20116673824027892 0.7729006085865621 0.003849196798243659 0.008888293496313966 1.5340180828770777e-07 6.814169520929773 -0.03949317625609938 ALEKEEEEEK(ub)QK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALEKEEEEEKQK 12 2 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 4229000.0 1051800.0 1040100.0 2137100.0 True False 1595657.4968799262 854486.0286616087 1714701.2482757962 1.0 0.5355071688833165 1.074604826930994 20.605719583929215 -6.678727908523823 1.9063848863830146 0.7057739756795823 1.0725335819085078 0.3183040638745692 0.19691829687308368 0.44136550237109407 3.1001676587363627 0.08291740090206685 0.219047907493358 2.0954248572308656e-07 6.678727908523823 0.36675960622892545 ALEKEEEEEK(ub)QK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALEKEEEEEKQK 12 2 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 3000110.0 1078600.0 1155500.0 766010.0 True False 896903.6900818041 1149275.092151207 926179.1493699299 1.0 1.2813807155218468 1.0326405829431426 19.774593550661464 -10.634282092660591 2.949217052819977 0.9869183421074292 1.1570106491231589 0.3469420331060099 0.10154773567269607 37506792.1759288 44442593.95546579 3822026.4478316368 0.03716266300832496 2.3212285703094545e-11 10.634282092660591 0.17009230701572964 ALELDHK(ub)NAQAQQEFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALELDHKNAQAQQEFK 16 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EK03;K7EIH8;K7EPP7;K7ESP1;K7EJV7;K7EN19;K7EJL5 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 10511700.0 6114000.0 2868300.0 1529400.0 True False 8015513.208060223 2440360.8205458308 1371152.3590407262 1.0 0.30445471889334025 0.1710623291920879 22.93436346387993 -13.999999999999998 0.2322003317590166 5.435955696716871 0.10754885628436621 0.9995128766332665 0.008021154497586537 13.360814207730758 0.15255973740202824 27.35890148663169 0.06830725916243137 1.0000000000000041e-14 13.999999999999998 -5.328406840432504 ALELDHK(ub)NAQAQQEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALELDHKNAQAQQEFK 16 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EK03;K7EIH8;K7EPP7;K7ESP1;K7EJV7;K7EN19;K7EJL5 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 26567300.0 1584500.0 8411600.0 16571200.0 True False 1534200.9148114508 11770395.745914506 12230705.594656114 1.0 7.672004124284502 7.972036437065503 20.549055995986226 -9.88230519247839 0.7502365305554678 1.9652657388837812e-18 7.9148174308545585 0.9997682815840309 0.04898936435056634 1.1637459687134162 0.3811742033560917 3.0012477155958384 0.04468763292669979 1.3112780985445367e-10 9.88230519247839 7.9148174308545585 ALELDHK(ub)NAQAQQEFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALELDHKNAQAQQEFK 16 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EK03;K7EIH8;K7EPP7;K7ESP1;K7EJV7;K7EN19;K7EJL5 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 45256700.0 3552700.0 8693000.0 33011000.0 True False 5389705.637160403 7141666.231280988 26486361.38076473 1.0 1.3250568235195153 4.914250084113911 22.36177505057548 -6.924629598562515 0.7896236345572509 0.933220236241105 5.559528943371023 0.9953733847914863 0.12063551545363216 0.09552401855123481 0.09205341553630007 0.10657522494486013 0.3348606771235618 1.1895163105858506e-07 6.924629598562515 4.626308707129918 up ALELDHK(ub)NAQAQQEFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALELDHKNAQAQQEFK 16 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EK03;K7EIH8;K7EPP7;K7ESP1;K7EJV7;K7EN19;K7EJL5 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 8128700.0 6114000.0 0.0 2014700.0 True False 8374511.024637422 0.0 1538869.3540489583 1.0 0.0 0.18375632314790397 22.99757352540282 -10.33621168527826 5.19224797483118 1.000324780979191 0.09187816157387366 0.9702064822920726 0.07501820478733179 0.0002821388729493427 3.6069367351148235e-05 0.07266092906416573 0.024212021483603244 4.6109277238670066e-11 10.33621168527826 -0.9084466194053175 ALELDHK(ub)NAQAQQEFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALELDHKNAQAQQEFK 16 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EK03;K7EIH8;K7EPP7;K7ESP1;K7EJV7;K7EN19;K7EJL5 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 21408700.0 1584500.0 9466200.0 10358000.0 True False 1317581.955251827 9415203.70170641 12523809.910019115 1.0 7.145820162592391 9.50514680327833 20.329461271420502 -8.874928130832027 0.4251022068219471 3.094745892455451e-21 9.840494002271898 0.9970291660867222 0.19540594799530786 0.38663337869985676 0.1529213625899902 1.3100334923065173 0.5556269925993974 1.333742128051009e-09 8.874928130832027 9.840494002271898 ALELDHK(ub)NAQAQQEFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALELDHKNAQAQQEFK 16 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EK03;K7EIH8;K7EPP7;K7ESP1;K7EJV7;K7EN19;K7EJL5 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 50044700.0 3552700.0 19392000.0 27100000.0 True False 4599040.184186671 18312818.153062005 22168078.069481663 1.0 3.981878265823542 4.8201531584143 22.13290137266793 -9.46654910183507 0.3845432107972955 1.4104785638289938e-24 4.960586338289562 0.9982897561922397 0.06779639421874759 0.8177642660428948 0.15677112572403307 1.3512676234318817 0.22066900848221163 3.415473327675952e-10 9.46654910183507 4.960586338289562 ALELDPDNETYK(ub)SNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALELDPDNETYKSNLK 16 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 14113000.0 0.0 0.0 14113000.0 True False 0.0 0.0 12652722.141455293 0.0 ALELDPDNETYK(ub)SNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALELDPDNETYKSNLK 16 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 ALELDPDNETYK(ub)SNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALELDPDNETYKSNLK 16 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 10382000.0 0.0 0.0 10382000.0 True False 0.0 0.0 12552828.199055655 0.0 ALELDSNLYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALELDSNLYR 10 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 12149100.0 4537000.0 1486100.0 6126000.0 False True 4392975.418428244 2079507.4799091187 4521416.823939318 1.0 0.4733710712756828 1.0292379067208686 22.066766995954737 -10.090758134908516 13.436315911271171 1.0000082094436857 0.7513044889982756 0.21066579387143658 0.2269316853455518 0.0 0.0 0.2197256594951607 0.0732418864983869 8.114128199790725e-11 10.090758134908516 -0.24870372044541011 ALELDSNLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALELDSNLYR 10 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 16107500.0 3283200.0 5247600.0 7576700.0 False True 4497087.765143864 5015743.680507377 5787239.507034663 1.0 1.1153315084005084 1.286886049209566 22.100559609235543 -6.9653960123272185 0.351189179252438 0.9836465153939533 1.424370494106715 0.9999210754748497 0.0010471177815714874 0.077826824691983 0.014387531329107547 0.0023478278860455857 0.014734028706245557 1.0829389835003854e-07 6.9653960123272185 0.4407239787127617 ALELDSNLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALELDSNLYR 10 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 8560900.0 4537000.0 2783300.0 1240600.0 False True 3772716.523179261 2768305.8104582047 1500003.7241137023 1.0 0.7337698958959574 0.3975924814116837 21.847172271389013 -6.967960611400764 0.3029682225294058 1.0562855075928848 0.06449839411933979 0.9999618174816746 0.0015230621016881288 0.07697018277264578 0.011386401981793243 0.005496813900835857 0.030056793037869296 1.0765628487172772e-07 6.967960611400764 -0.991787113473545 down ALELDSNNEK(ub)GLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALELDSNNEKGLFR 14 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 1 7936500.0 2051600.0 2904200.0 2980700.0 True False 1986473.0809890626 4063862.2052029227 2199965.2509167367 1.0 2.045767568710033 1.1074729740719047 20.921777812693946 -6.6201796299040865 2.115960101957 1.6938127527204414 1.1110539784502294 0.08336738992023163 0.4496967648349894 0.5849894235576191 4.97718628602555 0.17460777259378651 0.4986546152028848 2.3978409353678237e-07 6.6201796299040865 -0.582758774270212 ALELDSNNEK(ub)GLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALELDSNNEKGLFR 14 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 1 8091200.0 2051600.0 3038200.0 3001400.0 True False 1705996.3012904045 3021832.613564515 3628978.8630943615 1.0 1.7713008001710322 2.1271903463972492 20.702183088128223 -10.041570702888365 0.1828720599838148 7.809261200631859e-16 2.5018022165082137 0.999527800773982 0.01022348819147941 1.5920536045184885 0.08517755506180294 1.0187767553148794 0.24136855551479153 9.087183482056529e-11 10.041570702888365 2.5018022165082128 ALELNMLSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALELNMLSLK 10 0 Q9Y617 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 16165700.0 10078000.0 1551600.0 4536100.0 False True 9758079.406418286 2171161.971487107 3347959.3299169396 1.0 0.22249890383747498 0.34309613505654096 23.218165792573743 -10.15285033167923 5.62871657011117 1.0000122257649247 0.28279751958322447 0.9792346549460199 0.04923361348008214 7.553655040789182e-06 1.136844994154302e-06 0.047671052682262655 0.015890080423465132 7.033146572653908e-11 10.15285033167923 -0.7172147061817002 ALELNMLSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALELNMLSLK 10 0 Q9Y617 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 14657000.0 10078000.0 1878400.0 2700600.0 False True 8380303.531099962 1868280.686366793 3265282.973836418 1.0 0.22293711432210744 0.3896377931561425 22.99857106800802 -10.358346605841287 8.597883896245104 1.0000021101734875 0.3062874538336448 0.9584889228131946 0.06805526715316029 2.7527156526581445e-06 2.0545169028941837e-07 0.06589442926876418 0.021964743025490525 4.381808506777386e-11 10.358346605841287 -0.6937146563398426 ALELNMLSLK(ub)GHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALELNMLSLKGHR 13 1 Q9Y617 Q9Y617 PSAT1 Phosphoserine aminotransferase 1 72595300.0 4129600.0 51296000.0 17169700.0 True False 5413945.591103281 43642836.75024196 15393144.147392126 1.0 8.061188649911829 2.843239535448533 22.368248958199565 -6.568667083843084 2.3119883250763107 5.8409213025098214 2.8537943690116543 0.0 3.0763988248150254 0.7341389469896658 7.365005081572705 1.1255056794814635 3.449748875373374 2.6998082254067305e-07 6.568667083843084 -2.987126933498167 ALELNMLSLK(ub)GHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALELNMLSLKGHR 13 1 Q9Y617 Q9Y617 PSAT1 Phosphoserine aminotransferase 1 157469000.0 59356000.0 34319000.0 63794000.0 True False 57471776.26983174 48022755.67122071 47084437.62102274 1.0 0.8355885060129761 0.8192619173620086 25.776350303189556 -13.999999998722977 0.3264943905584953 2.7524127749285574 0.8162504515043 0.9997075148157945 0.0013959571566657036 18.531677567907074 0.18253754981560172 22.25944030668445 0.00530143242582875 1.000000002940454e-14 13.999999998722977 -1.9361623234242575 ALELNMLSLK(ub)GHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALELNMLSLKGHR 13 1 Q9Y617 Q9Y617 PSAT1 Phosphoserine aminotransferase 1 108503500.0 29723500.0 32684000.0 46096000.0 True False 45092722.5789223 26851284.838742435 36985105.39540551 1.0 0.5954682552544196 0.8202012049876417 25.42639128291464 -10.122433694244288 5.2536117259440545 1.0000071653260165 0.7078347301207895 0.6926410727801486 0.09174684254033277 7.700051891424902e-06 1.2863404845312285e-06 0.08883567518392924 0.029611166102030326 7.543385554272933e-11 10.122433694244288 -0.29217243520522707 ALELNMLSLK(ub)GHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALELNMLSLKGHR 13 1 Q9Y617 Q9Y617 PSAT1 Phosphoserine aminotransferase 1 33586200.0 4129600.0 21603700.0 7852900.0 True False 5656424.71824381 20649177.10011759 5998206.755552225 1.0 3.650570480239448 1.0604236871050465 22.431459019722457 -6.640819460315071 2.0413561125351913 2.7322635196178804 1.071205821206735 0.1577375978145461 1.1338739208416577 0.5313661845871449 4.232917277818867 0.4521555265543424 1.2556826333494089 2.2865491425716655e-07 6.640819460315071 -1.6610576984111454 ALELNMLSLK(ub)GHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALELNMLSLKGHR 13 1 Q9Y617 Q9Y617 PSAT1 Phosphoserine aminotransferase 1 120448700.0 59356000.0 40236000.0 20856700.0 True False 49357143.91664713 40019240.68177934 25217739.53951494 1.0 0.8108094898959842 0.5109238002527436 25.556755578623832 -6.964324287121193 0.36947168438299854 1.0232000000294013 0.2881034834517544 0.999898522852698 0.0020284296373749215 0.07819108076579019 0.015673453460993282 0.003955920067223246 0.025476332194142515 1.0856146938237094e-07 6.964324287121193 -0.7350965165776469 ALELNMLSLK(ub)GHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALELNMLSLKGHR 13 1 Q9Y617 Q9Y617 PSAT1 Phosphoserine aminotransferase 1 90541400.0 29723500.0 48070000.0 12747900.0 True False 38477656.687779024 45394862.24307393 10427913.004499825 1.0 1.1797720066849056 0.2710121639972909 25.19751760500709 -6.85531167998591 1.2091079893084482 1.096569863590866 0.2307696772436106 0.9476891598039321 0.08987052090031232 0.15171443344836186 0.42414279146956757 0.05807010728237856 0.13492307743072102 1.3953665893216555e-07 6.85531167998591 -0.8658001863472554 down ALELTGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALELTGLK 8 0 P19338 P19338 NCL Nucleolin 0 23082000.0 1256400.0 12458000.0 9367600.0 False True 1647152.5669949066 10599314.960903652 8398330.612364259 1.0 6.4349321206117684 5.098696247480169 20.65154275975756 -9.612985164034678 7.015912815477711 0.999999998518541 5.766814184048571 0.9443452941561963 0.5455160108718512 6.550055333816894e-09 2.4201171134494856e-17 0.5281936062948688 0.17606453543162298 2.4378940980235367e-10 9.612985164034678 4.766814185530031 ALELTGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALELTGLK 8 0 P19338 P19338 NCL Nucleolin 0 23678600.0 7916100.0 3624500.0 12138000.0 False True 7664807.738554066 5071781.751517805 8958693.667805342 1.0 0.6616971911776323 1.1688086607499646 22.869818173587436 -6.726860339262164 1.7346225040764023 0.795715325703233 1.1683458340578214 0.5448254846129927 0.1422511860218637 0.34207963380031947 2.014971190358626 0.06502663721941401 0.16193933075385306 1.8755975671366172e-07 6.726860339262164 0.37263050835458844 ALELTGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALELTGLK 8 0 P19338 P19338 NCL Nucleolin 0 23759400.0 1256400.0 11570000.0 10933000.0 False True 1720925.0329333416 11058799.143126437 8350850.572202945 1.0 6.426078377322779 4.852535939911804 20.714752821280452 -9.369411743709001 8.142213074840772 0.9999986951782684 5.639307158620879 0.9205726627835655 0.6423960100592194 0.0 0.0 0.6219972621511529 0.20733242071705094 4.271577165956294e-10 9.369411743709001 4.63930846344261 ALELTGLK(ub)VFGNEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALELTGLKVFGNEIK 15 1 P19338 P19338 NCL Nucleolin 1 10540600.0 6402500.0 0.0 4138100.0 True False 8393739.501898203 0.0 3709929.1074581034 1.0 0.0 0.4419876393136958 23.00088225947779 -10.426951195371169 5.688468961226506 1.000428322180564 0.22099381965685036 0.8055196077633093 0.18044069815597977 0.000980679573901447 9.879244385997773e-05 0.17480146133825414 0.058236984911345026 3.741526319891809e-11 10.426951195371169 -0.7794345025237137 ALELTGLK(ub)VFGNEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALELTGLKVFGNEIK 15 1 P19338 P19338 NCL Nucleolin 1 56142000.0 26441000.0 15633000.0 14068000.0 True False 25601644.92807165 21875338.42501803 10383168.769046433 1.0 0.8544505045077082 0.40556647036618776 24.6097331718326 -6.950827619052109 0.5496815198295846 1.0062196781935324 0.23272085659149985 0.9992646481514114 0.0068604053161103 0.08315508150004833 0.03459994310490181 0.007449170971655447 0.03723650335388459 1.1198823009615469e-07 6.950827619052109 -0.7734988216020325 down ALELTGLK(ub)VFGNEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALELTGLKVFGNEIK 15 1 P19338 P19338 NCL Nucleolin 1 50915000.0 0.0 17329000.0 33586000.0 True False 0.0 14236504.557905022 26947712.37873325 0.0 ALELTGLK(ub)VFGNEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALELTGLKVFGNEIK 15 1 P19338 P19338 NCL Nucleolin 1 25876700.0 6402500.0 9659900.0 9814300.0 True False 8769677.271056775 9233093.67698246 7496364.471853213 1.0 1.052843039897846 0.8548050561215096 23.064092321000683 -6.835720981386759 1.3021917695246081 1.0281442713260236 0.8488270715470192 0.9168295613044566 0.024146479724144028 0.17385820664225535 0.5745246211018983 0.014549824552470308 0.033489953642164866 1.459751797200099e-07 6.835720981386759 -0.1793171997790044 ALELTGLK(ub)VFGNEIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALELTGLKVFGNEIK 15 1 P19338 P19338 NCL Nucleolin 1 55446000.0 26441000.0 18331000.0 10674000.0 True False 21986863.034909137 18232247.26458138 12905884.049000207 1.0 0.829233676292682 0.5869816002632657 24.390138447266875 -6.966167675831248 0.3374120566220187 1.0270760390809257 0.38111999209490344 0.9999352298833752 0.001363750229953336 0.07756692088901768 0.013474967211226015 0.00344747319916511 0.02100823170606678 1.081016503358668e-07 6.966167675831248 -0.6459560469860223 ALELTGLK(ub)VFGNEIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALELTGLKVFGNEIK 15 1 P19338 P19338 NCL Nucleolin 1 50049000.0 0.0 14983000.0 35066000.0 True False 0.0 14149182.87888449 28684347.807543993 0.0 ALELYK(ub)INAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALELYKINAK 10 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77;A0A0D9SF91;A0A0D9SES7 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 19279200.0 3524100.0 4983600.0 10771500.0 True False 4620129.227432947 4240066.305920646 9656968.50752397 1.0 0.9177375993607276 2.090194458238046 22.13950177446535 -6.890063037617591 1.0219763714570147 0.9370979303492708 2.1911738505684433 0.980939786923393 0.07377422075328152 0.11909334292893001 0.22153266603140034 0.0549972667958216 0.13714461266920225 1.288062576512449e-07 6.890063037617591 1.2540759202191725 up ALELYK(ub)INAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALELYKINAK 10 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77;A0A0D9SF91;A0A0D9SES7 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 23946500.0 3524100.0 9531400.0 10891000.0 True False 4827055.00522158 9110271.231875148 8318770.107185783 1.0 1.887335284561762 1.7233634375798708 22.202711835988243 -10.076372814084918 4.460735300246346 0.9999502125113291 1.805349360938733 0.9698467365407886 0.06694122671203255 9889178.817450091 7446238.247445273 5237.129513237609 0.022915763343538984 8.387396729326521e-11 10.076372814084918 0.8053991484274039 ALELYK(ub)INAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALELYKINAK 10 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77;A0A0D9SF91;A0A0D9SES7 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 34051300.0 16373200.0 11644000.0 6034100.0 True False 21195430.164023224 10996001.16410137 4935955.715094431 1.0 0.5187911299278937 0.2328782986189467 24.337249910585932 -8.632528322674615 0.23790958538603135 1.272582183383587 1.7179714142113832e-20 0.9994025809942038 0.007736942393684253 0.2261063551105515 0.06681556405983025 0.16202803300697435 0.11592839736942369 2.33062111801169e-09 8.632528322674615 -1.272582183383587 down ALENDPDCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALENDPDCR 9 0 P13796;Q5TBN3;P13797;A0A0A0MSQ0;P13797-2;P13797-3;U3KQI3 P13796;P13797 LCP1;PLS3 Plastin-2;Plastin-3 0 29871970.0 461970.0 14799000.0 14611000.0 False True 605647.1437238435 12591046.886050178 13099193.878608622 1.0 20.78941016485881 21.628425089347818 19.208117983871116 -9.563583085885506 0.9067476958973232 1.687228729757967e-21 21.425196321285927 0.9997424413084907 0.15298732017299485 0.9398281289495922 0.4972911266210132 3.6707706435634635 0.11394834439744479 2.731598805377885e-10 9.563583085885506 21.425196321285927 ALENDPDCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALENDPDCR 9 0 P13796;Q5TBN3;P13797;A0A0A0MSQ0;P13797-2;P13797-3;U3KQI3 P13796;P13797 LCP1;PLS3 Plastin-2;Plastin-3 0 7919170.0 4785900.0 920770.0 2212500.0 False True 4633974.224169217 1288438.2627521185 1632979.8764227475 1.0 0.27804174137008947 0.35239295633231743 22.143818588760688 -10.409178144972392 5.963936911860863 1.0002050824416968 0.31521734887006336 0.9912358676200409 0.030353756402241958 8.279466287599783e-05 8.202092102917117e-06 0.0293984649087612 0.009796632753393146 3.8978206763086305e-11 10.409178144972392 -0.6849877335716335 ALENDPDCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALENDPDCR 9 0 P13796;Q5TBN3;P13797;A0A0A0MSQ0;P13797-2;P13797-3;U3KQI3 P13796;P13797 LCP1;PLS3 Plastin-2;Plastin-3 0 30986970.0 461970.0 15162000.0 15363000.0 False True 632772.7932698311 14492092.705970895 11734575.810916824 1.0 22.902521821590206 18.544690820663792 19.271328045394007 -9.369142055212974 9.310368532304363 0.999999999999981 20.723606321127406 0.9646806307498792 1.779077056260075 0.0 0.0 1.7225839397938478 0.5741946508760326 4.2742305567476247e-10 9.369142055212974 19.723606321127424 ALEQFATVVEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALEQFATVVEAK 12 0 P49748-2;P49748;P49748-3;G3V1M7;J3QRJ8;K7EMF8 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 6336190.0 760190.0 2913500.0 2662500.0 False True 996616.4516904312 2478817.156734051 2387010.0405034213 1.0 2.487232829168689 2.395114024512284 19.92667886400742 -10.163128876606525 5.385638691126351 0.9999551674147773 2.4411734268408525 0.9969451027030684 0.037607344521869535 2.0246805548254304e-05 3.146085625270684e-06 0.036414276209639065 0.012137718252166538 6.868645831478705e-11 10.163128876606525 1.4412182594260752 ALEQFATVVEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALEQFATVVEAK 12 0 P49748-2;P49748;P49748-3;G3V1M7;J3QRJ8;K7EMF8 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 6089790.0 760190.0 2675100.0 2654500.0 False True 1041252.7863623024 2556905.2366272756 2027561.771143572 1.0 2.4556047005262025 1.9472329848230387 19.989888925530312 -9.667042035399598 6.23151554895451 0.9999999941244045 2.2014188426802357 0.881610809347037 0.20754188387606173 1.734626272041021e-08 3.8442161762346335e-09 0.20095156346707094 0.0669838549880928 2.152573376882023e-10 9.667042035399598 1.2014188485558313 ALEQQVEEMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALEQQVEEMK 10 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 9931700.0 2441200.0 850100.0 6640400.0 False True 2363705.442245318 1189549.3632129368 4901080.03227011 1.0 0.5032561764899803 2.0734732613783313 21.172618831790018 -6.821636368050455 1.3647461398953022 0.7326915259556157 2.108980518154536 0.888113387754293 0.21919196560392312 0.19136281928582918 0.6998891570312225 0.12619604728008935 0.290747128055889 1.5078690667586087e-07 6.821636368050455 1.3762889921989203 up ALESDMAPVLIMATNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALESDMAPVLIMATNR 16 0 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 0 7435050.0 900150.0 2901700.0 3633200.0 False True 1180105.3670650003 2468777.670738013 3257271.3161153155 1.0 2.091997663630685 2.760152954999572 20.170484247348273 -8.654771309965597 0.18038359029735726 6.435835742576979e-17 3.6600913763002563 0.9997623867147637 0.011183224933609908 0.238085931715175 0.05045387772936593 0.505343917795751 0.37808905199602727 2.2142603840586653e-09 8.654771309965597 3.6600913763002563 ALESDMAPVLIMATNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALESDMAPVLIMATNR 16 0 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 0 6670970.0 2979200.0 800070.0 2891700.0 False True 2884626.9267316344 1119542.1233099313 2134277.020859509 1.0 0.3881063831635257 0.7398797401082664 21.459953314275424 -10.291834501071829 5.862393304852206 1.000030757336268 0.5639930616359591 0.6719513877625606 0.1436108716034312 5.773560157106472e-05 6.974392714208972e-06 0.13906041354459206 0.04635020950453409 5.1069957792663896e-11 10.291834501071829 -0.4360376957003088 ALESGHFPQPEK(ub)ESFQER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALESGHFPQPEKESFQER 18 1 Q14674;Q14674-2 Q14674 ESPL1 Separin 1 20870700.0 4396900.0 5608800.0 10865000.0 True False 5691873.725856506 5296665.349468551 8887681.484314322 1.0 0.9305662079970889 1.5614684921663322 22.44047222537315 -6.879611905198496 1.0820192747313113 0.9571889793080345 1.6058384745105054 0.9733685200279124 0.04609677611547894 0.12797174335993558 0.2743999868797403 0.0328303978934845 0.07931083129350737 1.319435287372665e-07 6.879611905198496 0.648649495202471 ALESPERPFLAILGGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALESPERPFLAILGGAK 17 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 267180000.0 60196000.0 129600000.0 77384000.0 False True 78917538.9388932 110264185.1768433 69377045.99974337 1.0 1.397207599976251 0.8791080782874242 26.233842630206915 -6.701804519504115 1.8239638070510469 1.2461983077202001 0.880569239165146 0.4264345545682786 0.16760957888997172 0.39174169691085514 2.534855196967358 0.07326841846577901 0.18804135216545156 1.986989080706646e-07 6.701804519504115 -0.36562906855505417 ALESPERPFLAILGGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALESPERPFLAILGGAK 17 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 235414000.0 84331000.0 58000000.0 93083000.0 False True 81653958.5654555 81159702.46600433 68701769.86985695 1.0 0.993946942583868 0.8413770878577087 26.283019493223435 -6.915262220768141 0.8591227910056932 1.0039745829888271 0.8192680481325162 0.992760617337664 0.006244391951414113 0.10104031102201262 0.12065029031979259 0.005249308757201764 0.015077612905802004 1.215451906653592e-07 6.915262220768141 -0.18470653485631094 ALESPERPFLAILGGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALESPERPFLAILGGAK 17 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 487876000.0 42715000.0 384770000.0 60391000.0 False True 64801777.8847938 316104787.2782686 48454692.37968441 1.0 4.87802646156171 0.7477370831681247 25.94953005927189 -6.660354865195485 1.9715245091956983 3.495464607469323 0.7648836605039161 0.23720653063828712 1.6510258054426015 0.48356679714209344 3.613561804233672 0.6764760834316014 1.8304412859836086 2.1859747180822978e-07 6.660354865195485 -2.7305809469654068 ALESPERPFLAILGGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALESPERPFLAILGGAK 17 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 313473000.0 60196000.0 93827000.0 159450000.0 False True 82452087.93573341 89681412.89560288 121791193.97583088 1.0 1.0876791011709044 1.477114734447477 26.297052691729807 -6.942477679212355 0.6361004745679936 0.9957460471358163 1.5902566387687618 0.9984707014817038 0.008109097316107813 0.08665435567327043 0.049598122747216616 0.008050505449861597 0.033169390765821545 1.1416219773581337e-07 6.942477679212355 0.5945105916329455 ALESPERPFLAILGGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALESPERPFLAILGGAK 17 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 163888000.0 84331000.0 31245000.0 48312000.0 False True 70124962.99674448 31076676.9833531 58413815.830550596 1.0 0.44316140294855944 0.8329960307182255 26.06342476865771 -10.170673140077342 5.5800631502199005 1.0000085293880323 0.6380787168333726 0.534716626763945 0.15914932035069657 1.6887843721412803e-05 2.50986595784266e-06 0.1540992975826843 0.05136522227318986 6.750358839490846e-11 10.170673140077342 -0.3619298125546597 ALESPERPFLAILGGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALESPERPFLAILGGAK 17 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 220518000.0 42715000.0 116340000.0 61463000.0 False True 55295409.53852955 109865576.7289209 50277364.66363655 1.0 1.9868842214174605 0.909250244879795 25.72065638136434 -6.66583546511526 1.9523456672936212 1.6321649230837385 0.9136929100200887 0.26069636047260714 0.41961303478954615 0.47071765290482787 3.4549981144837925 0.17328730881243568 0.46547363440365175 2.158562037518678e-07 6.66583546511526 -0.7184720130636498 ALESPERPFLAILGGAK(ub)VADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALESPERPFLAILGGAKVADK 21 2 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 35494100.0 15824000.0 12463000.0 7207100.0 True False 15321675.781619668 17439540.893686388 5319344.301634527 1.0 1.1382267280846246 0.34717770937404696 23.8690707623631 -6.861816478134509 1.1766261509052278 1.0753797857836647 0.30753966766963187 0.9558041346411787 0.0725225122968444 0.14493684302691204 0.3802765986805041 0.04803901748804779 0.11236885615753256 1.3746227331021936e-07 6.861816478134509 -0.7678401181140329 down ALESPERPFLAILGGAK(ub)VADK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALESPERPFLAILGGAKVADK 21 2 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 33990900.0 15824000.0 16040000.0 2126900.0 True False 13158357.122060513 15953589.336309265 2571624.956325509 1.0 1.2124301832150788 0.19543662878810888 23.649476037797378 -6.852173171774362 1.2244231581343656 1.1136152584461059 0.15301383029818397 0.9434247174213038 0.10418463153545783 0.15508332556002224 0.4463007733513079 0.06653956333592981 0.15421853288265164 1.4054869846418455e-07 6.852173171774362 -0.9606014281479219 down ALESSIAPIVIFASNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALESSIAPIVIFASNR 16 0 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3;J3QLR1 Q9Y265 RUVBL1 RuvB-like 1 0 19421800.0 4827500.0 9577500.0 5016800.0 False True 6328899.249576507 8148574.332802592 4497709.660543683 1.0 1.2875184153623311 0.7106622310103362 22.593523170830974 -6.7711707604758296 1.5698168075488597 1.164665200629128 0.7072607841538424 0.7350749397130449 0.12121438666502396 0.2645399622189169 1.2867081562492013 0.060855378798916095 0.14471521788284814 1.6936717338302722e-07 6.7711707604758296 -0.4574044164752856 ALESSIAPIVIFASNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALESSIAPIVIFASNR 16 0 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3;J3QLR1 Q9Y265 RUVBL1 RuvB-like 1 0 26383600.0 8563400.0 7837200.0 9983000.0 False True 8291559.554368178 10966634.830458077 7368152.816419567 1.0 1.3226263115580723 0.8886329246152324 22.98321205219632 -6.707645069784953 1.8035992000480794 1.1988198055287826 0.8897219531273189 0.4538968695067348 0.13600425565362548 0.3798360683276447 2.407088811845772 0.060041915805375976 0.15297187211377125 1.960446207414127e-07 6.707645069784953 -0.3090978524014637 ALESSIAPIVIFASNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALESSIAPIVIFASNR 16 0 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3;J3QLR1 Q9Y265 RUVBL1 RuvB-like 1 0 30269600.0 2146000.0 20478000.0 7645600.0 False True 3255638.893615059 16823540.90465571 6134443.808814483 1.0 5.16750826931388 1.884251911612593 21.634509258092404 -6.586408969609238 2.24318144813857 3.8269654237450643 1.8934232727310736 0.0 1.8075733485630479 0.6800197694057264 6.445812742345679 0.6742086352989516 2.015932399752396 2.5917376061586267e-07 6.586408969609238 -1.9335421510139907 ALESSIAPIVIFASNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALESSIAPIVIFASNR 16 0 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3;J3QLR1 Q9Y265 RUVBL1 RuvB-like 1 0 40552500.0 4827500.0 18676000.0 17049000.0 False True 6612357.208282171 17850832.56672683 13022377.335176783 1.0 2.699617096361361 1.9694001586704775 22.656733232353865 -10.609259758357615 6.084127561114053 0.9944023220033001 2.3345086275159193 0.8166233307701678 0.2981098164800604 0.022590670117631658 0.0014508363851025005 0.28807575614958175 0.09621452954735195 2.458896459602826e-11 10.609259758357615 1.3401063055126192 ALESSIAPIVIFASNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALESSIAPIVIFASNR 16 0 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3;J3QLR1 Q9Y265 RUVBL1 RuvB-like 1 0 16866700.0 8563400.0 3745100.0 4558200.0 False True 7120846.522943198 3724924.402955853 5511298.5452644415 1.0 0.5231013463012066 0.7739667646967491 22.763617327630595 -10.127616454606923 5.059446033205616 1.0000135551927747 0.6485340554982683 0.7235369588011116 0.10241537819894946 1.566000825932743e-05 2.7001311662024184e-06 0.09916708450986782 0.03305442117965174 7.453899714098924e-11 10.127616454606923 -0.3514794996945064 ALESSIAPIVIFASNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALESSIAPIVIFASNR 16 0 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3;J3QLR1 Q9Y265 RUVBL1 RuvB-like 1 0 18261000.0 2146000.0 10624000.0 5491000.0 False True 2778039.303984179 10032765.06075344 4491694.342417851 1.0 3.6114554053878054 1.6168577370291342 21.405635580184853 -6.577798905866814 2.2749548101663346 2.7806154574808315 1.6215259566027507 0.0 1.1351065107424414 0.7059679144033152 6.8687354859462735 0.41947879666569726 1.2699901266660043 2.643632571950496e-07 6.577798905866814 -1.1590895008780808 ALETLTGALFQRPPLIAAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALETLTGALFQRPPLIAAVK 20 1 O60832;O60832-2;C9IYT0;H7C0M1;H7BZF2 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 0 30116900.0 16120000.0 9392600.0 4604300.0 False True 15608279.4236419 13143114.161761923 3398295.703960792 1.0 0.8420604094166853 0.21772391509171635 23.895808175019322 -6.94514724792464 0.6098101324495272 1.0069077588468653 0.02037428616601769 0.9987632092616407 0.011878125787030697 0.08549513864904648 0.044493937437471785 0.012076011224992356 0.052642008411294766 1.1346260544912005e-07 6.94514724792464 -0.9865334726808477 down ALETLTGALFQRPPLIAAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALETLTGALFQRPPLIAAVK 20 1 O60832;O60832-2;C9IYT0;H7C0M1;H7BZF2 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 0 11354800.0 1521200.0 2036500.0 7797100.0 False True 2083628.7488842723 1946520.696195074 5955585.566315146 1.0 0.9341974654733401 2.858275769857852 20.99066681725908 -6.898978906916186 0.9676767256119438 0.9177472312973287 3.056120562401107 0.9860521236562387 0.10533605546151377 0.11216161554315493 0.18167865510888842 0.08179404587797476 0.21175006074737393 1.261888821301445e-07 6.898978906916186 2.1383733311037783 up ALETLTGALFQRPPLIAAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALETLTGALFQRPPLIAAVK 20 1 O60832;O60832-2;C9IYT0;H7C0M1;H7BZF2 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 0 20691400.0 16120000.0 1828000.0 2743400.0 False True 13404494.237083908 1818152.2011704077 3317032.2559515773 1.0 0.13563750851117073 0.24745672587742362 23.6762134504536 -10.673705527103047 6.729176628885561 1.0051518304909663 0.19154712217064865 0.9858551659887749 0.04565000433078002 0.003528262127601232 0.0001710834973086095 0.044199884360730274 0.014733475543950702 2.119797974760699e-11 10.673705527103047 -0.8136047083203177 ALETLTGALFQRPPLIAAVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALETLTGALFQRPPLIAAVKR 21 2 O60832;O60832-2;C9IYT0;H7C0M1;H7BZF2 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 20814300.0 3911400.0 6472900.0 10430000.0 True False 3787234.747992109 9057562.725727577 7698070.106707007 1.0 2.3916031955847616 2.032636110235395 21.852713417340222 -10.20182211166359 5.986482726481157 0.9999798040048349 2.2121196529100873 0.9382818564145483 0.1465476989267071 3.950284621689203e-05 5.266647190421151e-06 0.14189655207700597 0.04729806644734152 6.28315666114459e-11 10.20182211166359 1.2121398489052524 ALETLTGALFQRPPLIAAVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALETLTGALFQRPPLIAAVKR 21 2 O60832;O60832-2;C9IYT0;H7C0M1;H7BZF2 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 27916100.0 5988200.0 4828900.0 17099000.0 True False 9084537.19606045 3967145.0666320915 13719375.155242074 1.0 0.4366920384620651 1.510189771823659 23.114981588796716 -6.764104307877102 1.5968093972664683 0.6744724467618959 1.514957441111064 0.7075663797201643 0.2370916758863183 0.27607941379638945 1.3882240627287197 0.11709629141424806 0.2802962778320106 1.7214550701029904e-07 6.764104307877102 0.8404849943491681 ALETLTGALFQRPPLIAAVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALETLTGALFQRPPLIAAVKR 21 2 O60832;O60832-2;C9IYT0;H7C0M1;H7BZF2 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 23542700.0 3911400.0 7319300.0 12312000.0 True False 3252502.404400117 7279869.478132706 14886382.27574391 1.0 2.2382364631872993 4.57690123629271 21.6331186927745 -6.961149032803014 0.4189261183491779 0.8954239981405244 6.007778769140745 0.9998104678551641 0.020418212448394975 0.07929319484503833 0.019633436584003367 0.03023258364319932 0.1947343483303061 1.0935810278324778e-07 6.961149032803014 5.112354771000221 ALETLTGALFQRPPLIAAVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALETLTGALFQRPPLIAAVKR 21 2 O60832;O60832-2;C9IYT0;H7C0M1;H7BZF2 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 20395300.0 5988200.0 4474000.0 9933100.0 True False 7751842.945069007 4225017.967037924 8125377.722212844 1.0 0.5450339999116575 1.048186577023138 22.886107910889166 -6.668529105689347 1.9425908017028932 0.7092427564976393 1.0461444896877221 0.2726943517239683 0.19332277043482932 0.46440909149092685 3.3772744885225 0.08015856240055906 0.21457492520024266 2.145215342255998e-07 6.668529105689347 0.33690173319008276 ALFAISCLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALFAISCLVR 10 0 Q9NZL4;Q9NZL4-3;K7EN20 Q9NZL4 HSPBP1 Hsp70-binding protein 1 0 29931000.0 4915900.0 8731100.0 16284000.0 False True 6733441.077202332 8345331.132113343 12438054.579507237 1.0 1.239385781568424 1.8472062704490326 22.682912541660794 -6.955128511321637 0.49938151893597355 0.9877617162995036 2.125018461673654 0.9995446959778673 0.00760920202392906 0.08148947705237612 0.027928345649461683 0.0089340431271356 0.05013865484500176 1.1088466498358344e-07 6.955128511321637 1.1372567453741502 ALFFGLFSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALFFGLFSR 9 0 P56937-3;P56937-2;P56937 P56937-3 HSD17B7 3-keto-steroid reductase 0 13966400.0 5126900.0 4304600.0 4534900.0 False True 7777882.126596021 3536410.4980066875 3638575.0272827223 1.0 0.4546752496947897 0.4678105129468116 22.890945940292752 -9.980174088193834 5.658212999740495 1.0000009141148933 0.46124288132041164 0.9995543850886454 0.005362448768805014 6.184033856006604e-08 1.1144194864484305e-08 0.005192177512870543 0.0017307228978393784 1.0467088876733493e-10 9.980174088193834 -0.5387580327944816 ALFFGLFSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALFFGLFSR 9 0 P56937-3;P56937-2;P56937 P56937-3 HSD17B7 3-keto-steroid reductase 0 14432000.0 5126900.0 5226900.0 4078200.0 False True 6636873.116307782 4936018.420185635 3336009.445865682 1.0 0.7437265009718365 0.5026477661097078 22.662072262385202 -6.971863821864521 0.2089300446013744 1.1279544513087345 0.11169790550965225 0.9999935002760438 0.0005176979540122413 0.07570245157884305 0.006821985470463279 0.007280905238531783 0.025043809798919008 1.0669306174108315e-07 6.971863821864521 -1.0162565457990822 ALFGIFIPSQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALFGIFIPSQR 11 0 F5H1D6;Q07864 F5H1D6 POLE DNA polymerase;DNA polymerase epsilon catalytic subunit A 0 2127470.0 771670.0 0.0 1355800.0 False True 1011666.8428629102 0.0 1215514.8217519382 1.0 0.0 1.2014971433798896 19.948302836349963 -10.756568152535012 6.22447328465939 1.0121902172996393 0.6007485716899449 0.12833260492331833 0.4905091547820548 0.08297888064192502 0.003245203353291892 0.47493847918427573 0.15831114896943113 1.7515875412424167e-11 10.756568152535012 -0.41144164560969443 ALFGIFIPSQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALFGIFIPSQR 11 0 F5H1D6;Q07864 F5H1D6 POLE DNA polymerase;DNA polymerase epsilon catalytic subunit A 0 1928370.0 771670.0 1156700.0 0.0 False True 1056977.2525976382 1105593.1693046116 0.0 1.0 1.0459952346065107 0.0 20.011512897872855 -6.991426880866923 1.1350748733663718 1.0376149090284343 3.56132509504567e-19 0.9818395406950062 0.06503703784848752 0.09398897974467241 0.23768574452584323 0.04818250914245117 0.08883795207826362 1.019936465179351e-07 6.991426880866923 -1.0376149090284343 down ALFGLYMSASHIASNPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALFGLYMSASHIASNPK 17 0 Q15006 Q15006 EMC2 ER membrane protein complex subunit 2 0 14889500.0 3473900.0 8324300.0 3091300.0 False True 4554316.5412954595 7082346.887867253 2771441.9298434663 1.0 1.5550844618834299 0.6085308091156834 22.11880313675098 -6.7477911812234534 1.6582747245277274 1.3272616322139517 0.6069901979956805 0.6393240414958801 0.23322772676088707 0.30390501353803584 1.6435864715305493 0.11114262029417461 0.2704259924964344 1.7873467657136621e-07 6.7477911812234534 -0.7202714342182711 ALFGLYMSASHIASNPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALFGLYMSASHIASNPK 17 0 Q15006 Q15006 EMC2 ER membrane protein complex subunit 2 0 21848700.0 8202600.0 5442100.0 8204000.0 False True 7942212.952876242 7615158.910176591 6055126.285275581 1.0 0.9588207915551786 0.7623978759072105 22.921109613382182 -6.940861372648408 0.6515018332177611 1.002176232692844 0.7080593081601327 0.998274542269648 0.004306422446553569 0.08737590445923894 0.05283680191627959 0.0042198551209150295 0.016842604819236412 1.1458786489990304e-07 6.940861372648408 -0.2941169245327113 ALFGLYMSASHIASNPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALFGLYMSASHIASNPK 17 0 Q15006 Q15006 EMC2 ER membrane protein complex subunit 2 0 129217200.0 30063400.0 38607300.0 60546500.0 False True 45608375.72894087 31717525.674788304 48579457.73652632 1.0 0.6954320378189197 1.065143341767818 25.442795455991757 -6.687866189629264 1.8736398777053602 0.8086680606363558 1.0638422520421345 0.36042128646524807 0.12886869574794826 0.42138308132011987 2.8662684450988545 0.05505236245588256 0.143765928745421 2.051794259292429e-07 6.687866189629264 0.2551741914057787 ALFGLYMSASHIASNPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALFGLYMSASHIASNPK 17 0 Q15006 Q15006 EMC2 ER membrane protein complex subunit 2 0 26396900.0 3473900.0 6890100.0 16032900.0 False True 4758294.708617594 6585672.599486221 12246259.227940418 1.0 1.3840405024848759 2.5736655625305453 22.18201319827387 -6.950728649143485 0.5507898976935897 0.9836243377582031 3.030043968220398 0.9992572062343543 0.018258123042248317 0.08319454481433332 0.03476217021615021 0.019796875733768066 0.09870419131090358 1.1201375362533633e-07 6.950728649143485 2.046419630462195 up ALFGLYMSASHIASNPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALFGLYMSASHIASNPK 17 0 Q15006 Q15006 EMC2 ER membrane protein complex subunit 2 0 16422300.0 8202600.0 3559800.0 4659900.0 False True 6820825.33679308 3540622.6508350256 5634263.545056773 1.0 0.5190900625670772 0.826038384924516 22.701514888816458 -10.677807503197986 5.176601597928966 1.0070349972487638 0.67256422374585 0.6027429171809422 0.12531112786317697 0.010320195743977132 0.000642329967560795 0.12307311119282532 0.040443992609045784 2.0998704245088287e-11 10.677807503197986 -0.33447077350291377 ALFGLYMSASHIASNPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALFGLYMSASHIASNPK 17 0 Q15006 Q15006 EMC2 ER membrane protein complex subunit 2 0 109029700.0 30063400.0 42657800.0 36308500.0 False True 38917663.93820973 40283855.93078009 29700725.556670617 1.0 1.0351046762400613 0.7631682519235222 25.213921778084206 -6.874451114285467 1.110220504744962 1.0205052920316715 0.7458306276887161 0.968930013731515 0.021287943732034405 0.13266168267450545 0.3029219546632574 0.014836439169602235 0.03542556085243126 1.335207876799048e-07 6.874451114285467 -0.2746746643429554 ALFKPGAWFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALFKPGAWFK 10 1 Q13895;H7BY94 Q13895 BYSL Bystin 0 14930700.0 3831200.0 4991200.0 6108300.0 False True 5022740.301393582 4246532.415545215 5476271.710950996 1.0 0.8454612742703411 1.090295612025089 22.2600432523416 -6.736118350595577 1.7010113580523927 0.9076391557584648 1.090318422692555 0.58736593836341 0.06493913400636239 0.32487584256018953 1.8441638356580088 0.03022150137567497 0.0744762249345806 1.836037932216112e-07 6.736118350595577 0.1826792669340903 ALFKPGAWFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALFKPGAWFK 10 1 Q13895;H7BY94 Q13895 BYSL Bystin 0 12819000.0 3966300.0 1411400.0 7441300.0 False True 3840391.9775428516 1974979.3803537658 5492200.295785129 1.0 0.5142650520839259 1.4301145112013105 21.872822139436376 -6.762640508322381 1.6027321294821004 0.7187788660511414 1.433878566525437 0.701553155956071 0.204384879799162 0.27851704899387514 1.4106612561435758 0.10059256788042864 0.24109427204379424 1.7272670632947178e-07 6.762640508322381 0.7150997004742956 ALFKPGAWFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALFKPGAWFK 10 1 Q13895;H7BY94 Q13895 BYSL Bystin 0 14367800.0 3831200.0 4153800.0 6382800.0 False True 5247698.174287033 3970271.3812202774 4875314.097892333 1.0 0.756573882368852 0.9290385872001311 22.32325331386449 -9.922097370703327 5.360560437118863 1.0000002619830382 0.8428062349693609 0.5255415706711832 0.07040842091591477 2.204308381390033e-07 4.4344265616326555e-08 0.06817277418347176 0.022724220136213884 1.196472246974647e-10 9.922097370703327 -0.15719402701367724 ALFKPGAWFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALFKPGAWFK 10 1 Q13895;H7BY94 Q13895 BYSL Bystin 0 10224800.0 3966300.0 2135500.0 4123000.0 False True 3298154.1868824954 2123995.637636439 4985100.237401895 1.0 0.6439952522790019 1.5114818637736118 21.653227414870653 -6.795309533790591 1.4753748357360266 0.8023934725341253 1.522063000773266 0.8179745130288947 0.15190287372422814 0.22752814181574335 0.9782535023471842 0.08102348410628954 0.18896229412536855 1.6021031200947994e-07 6.795309533790591 0.7196695282391408 ALFNAQFGSIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALFNAQFGSIFR 12 0 Q9H857;Q9H857-2;Q9H857-4;Q9H857-3 Q9H857 NT5DC2 5-nucleotidase domain-containing protein 2 0 8598800.0 2412200.0 3151800.0 3034800.0 False True 3162417.559778029 2681563.7256201757 2720788.007857191 1.0 0.8479473930724049 0.8603506514959283 21.59259644038815 -10.297692941102348 5.54258534630974 1.000018677232778 0.8541490222841635 0.994605322314627 0.00506360904759591 1.1688065593860182e-06 1.4809525607919753e-07 0.004903445916485235 0.0016342727927520866 5.038567243180913e-11 10.297692941102348 -0.14586965494861448 ALFNAQFGSIFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALFNAQFGSIFR 12 0 Q9H857;Q9H857-2;Q9H857-4;Q9H857-3 Q9H857 NT5DC2 5-nucleotidase domain-containing protein 2 0 8440900.0 4208600.0 2482400.0 1749900.0 False True 4075000.2966711666 3473635.2655449817 1291548.6941252723 1.0 0.8524257699766464 0.31694444174159386 21.958368733700038 -6.947116267843435 0.5896592684648296 1.0061956490793442 0.1362459123387179 0.9989550647797567 0.009486314944963348 0.08466491208347161 0.04091791934924677 0.009838263757318581 0.04485537105412813 1.1294934900321944e-07 6.947116267843435 -0.8699497367406264 down ALFNAQFGSIFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALFNAQFGSIFR 12 0 Q9H857;Q9H857-2;Q9H857-4;Q9H857-3 Q9H857 NT5DC2 5-nucleotidase domain-containing protein 2 0 13517400.0 2412200.0 3328500.0 7776700.0 False True 3304055.527253907 3181435.8641224215 5940003.626163964 1.0 0.9628881348633392 1.79779170693928 21.65580650191104 -6.896498962626071 0.9831499308749442 0.9618750917423502 1.8794517618964515 0.9847420363913328 0.04757222782186561 0.11402806271895603 0.19231609814974088 0.03651696489401282 0.09344582077182359 1.2691151759030593e-07 6.896498962626071 0.9175766701541013 ALFTYPK(ub)GAGEMLEDGSER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALFTYPKGAGEMLEDGSER 19 1 Q96DE5 Q96DE5 ANAPC16 Anaphase-promoting complex subunit 16 1 15444000.0 6416000.0 9028000.0 0.0 True False 9733541.072429746 7416882.863914047 0.0 1.0 0.7619922501711496 0.0 23.214533323790803 -7.313199367796925 0.8101962294857701 0.9890571206570881 2.6882002820623235e-19 0.9881547497935037 0.04642076824496254 0.10527371936009461 0.13752229817001205 0.03965192443655618 0.07028070601373226 4.861839662031371e-08 7.313199367796925 -0.9890571206570881 down ALFTYPK(ub)GAGEMLEDGSER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALFTYPKGAGEMLEDGSER 19 1 Q96DE5 Q96DE5 ANAPC16 Anaphase-promoting complex subunit 16 1 29226000.0 6416000.0 12316000.0 10494000.0 True False 8305638.478267711 11630603.773365887 8584199.677532844 1.0 1.4003262727842276 1.03353880619702 22.985659645883253 -10.631265754110391 7.291277237574594 0.9995555927999694 1.2169325394906239 0.31805813866424226 0.14974035619779874 0.0010839023884052941 5.48148692044333e-05 0.1452744171765978 0.04832849215077011 2.337406491774973e-11 10.631265754110391 0.21737694669065444 ALGDVTVLGSLLLQHLLHFSTPGLVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALGDVTVLGSLLLQHLLHFSTPGLVLR 27 0 Q86U38;A0A3B3ISH6;Q86U38-2 Q86U38 NOP9 Nucleolar protein 9 0 136253000.0 27931000.0 41667000.0 66655000.0 False True 42373369.029619 34231198.30424312 53480610.03407565 1.0 0.8078469823892336 1.2621278708495585 25.336654503536298 -6.79178592470864 1.489122719320611 0.8928528209594767 1.267203849001829 0.8070636365776 0.08178365500065454 0.23270838629470825 1.0193706670120914 0.04322386482433263 0.10107052671138171 1.6151545132180933e-07 6.79178592470864 0.3743510280423522 ALGFPEGLVIQAYFACEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALGFPEGLVIQAYFACEK 18 0 P54727;P54727-2 P54727 RAD23B UV excision repair protein RAD23 homolog B 0 31214000.0 16742000.0 14472000.0 0.0 False True 25398838.004148815 11889358.529747915 0.0 1.0 0.4681063963558423 0.0 24.598259159476726 -8.031361601525582 0.5739384205212432 1.0160743445867932 2.5892729920702343e-15 0.9898291176406507 0.04120007406261253 0.11238039049275256 0.16607906210677875 0.047072568899507984 0.07577631320517311 9.303329406850241e-09 8.031361601525582 -1.0160743445867906 ALGHGVDLGHIYGDNLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALGHGVDLGHIYGDNLER 18 0 X6RJD6;A0A2R8YDM0;A0A087X296;P23219-4;P23219-3;P23219-2;P23219;P23219-6;P23219-5 X6RJD6 PTGS1 Prostaglandin G/H synthase 1 0 77847000.0 34504000.0 21708000.0 21635000.0 False True 33408689.406534728 30376117.605724487 15968144.463912375 1.0 0.9092280525013031 0.47796380964256 24.993720052338492 -6.940950624930826 0.6506596695304345 1.004772618119866 0.35833946601204947 0.9982857805212714 0.00942875004539113 0.0873356188824533 0.052654728840869094 0.00924568723724389 0.0369653464132855 1.1456431825569275e-07 6.940950624930826 -0.6464331521078165 down ALGHGVDLGHIYGDNLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALGHGVDLGHIYGDNLER 18 0 X6RJD6;A0A2R8YDM0;A0A087X296;P23219-4;P23219-3;P23219-2;P23219;P23219-6;P23219-5 X6RJD6 PTGS1 Prostaglandin G/H synthase 1 0 67152000.0 10497000.0 14054000.0 42601000.0 False True 15924716.433493627 11545953.895596825 34180893.67731842 1.0 0.7250335630035346 2.146405169603367 23.92476434729689 -6.8565595545935745 1.2030766851995278 0.8519813972542506 2.2108185788625008 0.9493075157516455 0.13859168799228636 0.15039175045580924 0.4156130468911575 0.08996767065706467 0.20925298807134368 1.3913629848247302e-07 6.8565595545935745 1.35883718160825 up ALGHGVDLGHIYGDNLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALGHGVDLGHIYGDNLER 18 0 X6RJD6;A0A2R8YDM0;A0A087X296;P23219-4;P23219-3;P23219-2;P23219;P23219-6;P23219-5 X6RJD6 PTGS1 Prostaglandin G/H synthase 1 0 33687300.0 12230000.0 11688000.0 9769300.0 False True 16751761.503322829 11171585.512952622 7461992.545049123 1.0 0.6668901960391843 0.4454452472696071 23.9978094719306 -8.301593952636672 0.1439946516062386 1.4084431130959387 9.367044162013006e-11 0.9999331531089963 0.0018634702550022328 0.09150088041866257 0.03101515683803655 0.13749075581779135 0.13633571078747783 4.99351141922196e-09 8.301593952636672 -1.4084431130022683 down ALGHGVDLGHIYGDNLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALGHGVDLGHIYGDNLER 18 0 X6RJD6;A0A2R8YDM0;A0A087X296;P23219-4;P23219-3;P23219-2;P23219;P23219-6;P23219-5 X6RJD6 PTGS1 Prostaglandin G/H synthase 1 0 49042000.0 10497000.0 14253000.0 24292000.0 False True 13588573.426804272 13459808.020606058 19871105.256968543 1.0 0.990523993788471 1.4623393223729875 23.69589066938934 -6.902319766753424 0.9465036690662558 0.9816121915981152 1.5142618754329813 0.9876848002963019 0.02443825926547498 0.10971780788899825 0.1679542657929971 0.019277270690919317 0.05076485884707097 1.2522188390207305e-07 6.902319766753424 0.5326496838348661 ALGK(ub)STVVPVPYEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALGKSTVVPVPYEK 14 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;P78347-5 A0A494C1K3 GTF2I General transcription factor II-I 1 5237700.0 1618300.0 1450800.0 2168600.0 True False 2121606.9716394944 1234346.2951741058 1944214.074680079 1.0 0.5817978125421842 0.9163874839540459 21.016725990617516 -9.895774282195525 6.502245229869074 1.0000000165793301 0.7490926482481017 0.42850330245332036 0.13659566136080645 3.286070571006441e-08 5.455717580582406e-09 0.13225819025762103 0.044086060134542165 1.2712346379805433e-10 9.895774282195525 -0.2509073683312284 ALGLAISLDRPHTVLTVIQAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALGLAISLDRPHTVLTVIQAIR 22 1 Q12788;J3KNP2 Q12788 TBL3 Transducin beta-like protein 3 0 177941000.0 39793000.0 63032000.0 75116000.0 False True 60368890.25797956 51783447.12873618 60269289.675487675 1.0 0.8577836516034258 0.9983501339503468 25.847301945003966 -10.809904024923654 7.896580291700456 1.0022689278717343 0.9280668927774829 0.25880174829632074 0.057386026114649255 0.002360687029545741 5.682922701232825e-05 0.05722191511095972 0.018521260287255033 1.5491589309278236e-11 10.809904024923654 -0.07420203509425138 ALGLAISLDRPHTVLTVIQAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALGLAISLDRPHTVLTVIQAIR 22 1 Q12788;J3KNP2 Q12788 TBL3 Transducin beta-like protein 3 0 128482500.0 39793000.0 40664500.0 48025000.0 False True 51512822.93729846 38401484.828031614 39284942.77811277 1.0 0.7454742846217921 0.7626245376987105 25.618428267096416 -10.199892762984732 5.314201161595386 1.0000137694647413 0.7540494111601936 0.9963664929625976 0.007001561499879238 1.1422919898967107e-06 1.7197600893071872e-07 0.006779612118187797 0.0022597442571770546 6.311131611887149e-11 10.199892762984732 -0.24596435830454766 ALGLQFHSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALGLQFHSR 9 0 O43615 O43615 TIMM44 Mitochondrial import inner membrane translocase subunit TIM44 0 7171500.0 2614900.0 1945500.0 2611100.0 False True 3428159.2227276205 1655238.9834996036 2340928.419439805 1.0 0.48283608664553507 0.6828528861553991 21.709002687089917 -10.15364846880254 5.303885980873583 1.0000135315007792 0.5828444864002839 0.8529336004200023 0.08165651646459869 1.3066125209086443e-05 2.085024361379793e-06 0.07906614474178351 0.026354527364632344 7.020233075803425e-11 10.15364846880254 -0.41716904510049535 ALGLQFHSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALGLQFHSR 9 0 O43615 O43615 TIMM44 Mitochondrial import inner membrane translocase subunit TIM44 0 8628600.0 2614900.0 2315000.0 3698700.0 False True 3581699.195015438 2212715.645318732 2825143.237117624 1.0 0.6177837738015838 0.7887717765493277 21.77221274861281 -10.009849642082177 4.609316251302286 1.0000076891706104 0.703277775156231 0.8006063132401564 0.06980555987795369 22100271.413033437 23997095.897657573 1456.6418397267603 0.02389629760659765 9.77575610684913e-11 10.009849642082177 -0.2967299140143794 ALGLVTPAGVLLAGPPGCGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALGLVTPAGVLLAGPPGCGK 20 0 O15381-5;O15381;O15381-3;O15381-2;O15381-4 O15381-5 NVL Nuclear valosin-containing protein-like 0 2876780.0 678200.0 1283400.0 915180.0 False True 889126.7676981434 1091921.7226540172 820485.9526264481 1.0 1.2280832861222801 0.9227997428877334 19.76202960113103 -6.706745388580167 1.807090705102753 1.1406883116836135 0.9235928143285563 0.44948102129448686 0.09616386928313422 0.3816665180372823 2.4275476643948095 0.042383427717236716 0.10808943423635421 1.9645116626634828e-07 6.706745388580167 -0.21709549735505718 ALGLVTPAGVLLAGPPGCGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALGLVTPAGVLLAGPPGCGK 20 0 O15381-5;O15381;O15381-3;O15381-2;O15381-4 O15381-5 NVL Nuclear valosin-containing protein-like 0 3313100.0 678200.0 1329000.0 1305900.0 False True 928948.867665866 1270280.3855847053 997473.3158547335 1.0 1.3674384347725077 1.0737655758826061 19.82523966265392 -10.024812149257098 5.391292096007858 0.9999987807664581 1.2206020053278681 0.4293434443966764 0.11989144259852946 1.7569345771985066e-06 3.1796515614159806e-07 0.11608503186293999 0.03869479671124935 9.444693108941282e-11 10.024812149257098 0.22060322456141002 ALGMK(ub)LPETNLFETEETR ddPTM_RPMI8226_Bortezomib_1h_R1 2 ALGMKLPETNLFETEETR 18 1 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 1 30286800.0 10819000.0 13580600.0 5887200.0 True False 14183813.77134504 11554427.416764187 5278049.0180100445 1.0 0.8146206375119722 0.3721177606458049 23.757742163589487 -6.956444923374075 0.4829360253270244 1.0103333262132106 0.1578641091795322 0.9996147827921508 0.005169712382140284 0.08099636601990377 0.026015901792394186 0.00627679775397492 0.03649952899087216 1.1054906572906148e-07 6.956444923374075 -0.8524692170336784 down ALGMK(ub)LPETNLFETEETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALGMKLPETNLFETEETR 18 1 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 1 32800700.0 11075000.0 15547000.0 6178700.0 True False 10723430.187148504 21754998.17653397 4560313.112973208 1.0 2.0287350033393468 0.4252662658669159 23.354263129933734 -6.733401378805904 1.7106004524276446 1.61670288272763 0.42555589567950625 0.5751378078425089 0.43234992364456953 0.3298574500755974 1.8923882408496222 0.20016045142680056 0.49482663648830083 1.8475602980891725e-07 6.733401378805904 -1.1911469870481237 ALGMK(ub)LPETNLFETEETR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALGMKLPETNLFETEETR 18 1 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 1 20681300.0 7890900.0 8272000.0 4518400.0 True False 10808378.97355438 7906515.688154012 3451246.9793690406 1.0 0.7315172522632153 0.3193121732512756 23.36564683000574 -6.96486766674291 0.3603171394826016 1.0353912727056263 0.0013054241668008287 0.9999103901117415 0.0026500401569759663 0.07800590774893656 0.015018522804640678 0.005526803537053037 0.035200836910391005 1.0842572461824757e-07 6.96486766674291 -1.0340858485388253 down ALGMK(ub)LPETNLFETEETR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALGMKLPETNLFETEETR 18 1 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 1 29375700.0 11075000.0 13152000.0 5148700.0 True False 9209353.205688845 13081147.565532384 6225269.365100926 1.0 1.420419792070939 0.6759724842842842 23.13466840536801 -6.753498734549671 1.6369551849766544 1.2461718033515004 0.674095924952632 0.6638375605425008 0.1767026573841302 0.29399541010698443 1.551009541801434 0.08523646941768477 0.2061719763168949 1.7640109044563576e-07 6.753498734549671 -0.5720758783988683 ALGQNPTNAEVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALGQNPTNAEVLK 13 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;F8W1I5;P14649 P60660-2 MYL6;MYL6B Myosin light polypeptide 6;Myosin light chain 6B 0 32437200.0 12737000.0 2579200.0 17121000.0 False True 12332670.90688132 3609088.0103503126 12636496.481009644 1.0 0.29264447560475587 1.024635829207021 23.5559819446355 -10.989870651870916 13.058197833231482 1.251733726090946 0.6586401524058885 0.22478762668303187 0.2988342187424538 0.06592869056086792 5.1141388476205886e-05 0.00871031697514783 0.09644832937220231 1.0235978102151477e-11 10.989870651870916 -0.5930935736850576 ALGQNPTNAEVLK(ub)VLGNPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALGQNPTNAEVLKVLGNPK 19 1 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;F8W1I5;P14649 P60660-2 MYL6;MYL6B Myosin light polypeptide 6;Myosin light chain 6B 1 37297000.0 10068000.0 13992000.0 13237000.0 True False 13199245.498650696 11904448.140388826 11867362.218269954 1.0 0.9019036839344922 0.8990939837798384 23.65395212815394 ALGQNPTNAEVLK(ub)VLGNPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALGQNPTNAEVLKVLGNPK 19 1 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;F8W1I5;P14649 P60660-2 MYL6;MYL6B Myosin light polypeptide 6;Myosin light chain 6B 1 72076000.0 23765000.0 14728000.0 33583000.0 True False 23010593.083303306 20608967.20550536 24786604.831595514 1.0 0.8956295533494707 1.0771823543123231 24.45579483279369 -6.750799664866736 1.6467992013360446 0.9386884818826802 1.0775672146708979 0.6524402003969165 0.043859058525890934 0.2986525149547688 1.5937645146660022 0.021036342958142974 0.05102948204741591 1.7750080832256874e-07 6.750799664866736 0.13887873278821772 ALGQNPTNAEVLK(ub)VLGNPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALGQNPTNAEVLKVLGNPK 19 1 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;F8W1I5;P14649 P60660-2 MYL6;MYL6B Myosin light polypeptide 6;Myosin light chain 6B 1 145286000.0 30762000.0 39752000.0 74772000.0 True False 46668203.00344198 32657945.016206384 59993281.42626822 1.0 0.6997900693497394 1.2855279947643035 25.475936580454334 -6.76736423257868 1.5843719184149472 0.8272326297947293 1.2885139770930516 0.720465451606122 0.12644187783459024 0.2706992921400094 1.3406132027215605 0.06291819540363842 0.15014691147038117 1.7085817666462624e-07 6.76736423257868 0.46128134729832226 ALGQNPTNAEVLK(ub)VLGNPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALGQNPTNAEVLKVLGNPK 19 1 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;F8W1I5;P14649 P60660-2 MYL6;MYL6B Myosin light polypeptide 6;Myosin light chain 6B 1 34088000.0 10068000.0 11351000.0 12669000.0 True False 13790411.677469674 10849475.287262604 9676843.126245221 1.0 0.7867404933957209 0.7017080673563163 23.71716218967683 -13.999999999999993 0.12685025097793703 2.0134512587877156 0.5777215769690729 0.9996600980162843 0.0023132421445430404 11.942738714894464 0.11043402030407358 3.0268479760177693 0.11015270031563776 1.0000000000000164e-14 13.999999999999993 -1.4357296818186427 ALGQNPTNAEVLK(ub)VLGNPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALGQNPTNAEVLKVLGNPK 19 1 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;F8W1I5;P14649 P60660-2 MYL6;MYL6B Myosin light polypeptide 6;Myosin light chain 6B 1 60023000.0 23765000.0 19205000.0 17053000.0 True False 19761650.468008608 19101538.853105947 20618703.455836657 1.0 0.966596331821004 1.0433695044457698 24.236200108227965 -6.788447802839634 1.5025195607947928 0.9812930403243975 1.0441516153260333 0.7962634358693383 0.014186804318433471 0.23767073669618458 1.0600111512406403 0.0074326387583363955 0.017421577731220175 1.6276169245664762e-07 6.788447802839634 0.06285857500163583 ALGQNPTNAEVLK(ub)VLGNPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALGQNPTNAEVLKVLGNPK 19 1 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;F8W1I5;P14649 P60660-2 MYL6;MYL6B Myosin light polypeptide 6;Myosin light chain 6B 1 172041000.0 30762000.0 48017000.0 93262000.0 True False 39822015.40967444 45344811.739664696 76289272.9489298 1.0 1.138687012025226 1.9157562007872642 25.247062902546784 -6.937300952328001 0.6842165678106985 0.9907373123015019 2.1096503538671914 0.9977885276586925 0.018951589380477068 0.08901985301614261 0.060381357625727015 0.018090453989604054 0.06771438802276904 1.1553113705273718e-07 6.937300952328001 1.1189130415656896 ALGSDHCPITLYLAL ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALGSDHCPITLYLAL 15 0 P27695 P27695 APEX1 DNA-(apurinic or apyrimidinic site) lyase;DNA-(apurinic or apyrimidinic site) lyase, mitochondrial 0 260491000.0 66490000.0 93041000.0 100960000.0 False True 100870191.07011431 76437106.61734907 81005211.74766001 1.0 0.7577769587470897 0.8030639268974293 26.587924654563057 -10.474129252115084 6.099811501677564 1.0001361066887868 0.7804204428222612 0.9690838541650512 0.018488327327667652 3.4242293332807576e-05 2.9520602979401667e-06 0.017912276397369455 0.005967081986607349 3.356377088981868e-11 10.474129252115084 -0.21971566386652563 ALGSDHCPITLYLAL ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALGSDHCPITLYLAL 15 0 P27695 P27695 APEX1 DNA-(apurinic or apyrimidinic site) lyase;DNA-(apurinic or apyrimidinic site) lyase, mitochondrial 0 169496000.0 66490000.0 50700000.0 52306000.0 False True 86072615.71384348 47878500.43111813 42786844.70488213 1.0 0.556257063109302 0.49710171289706157 26.359050976655507 -13.999999999999998 0.28399912621415974 4.697403787964922 0.4799843202219664 0.9996140581851566 0.0044089865922266065 15.618748848939951 0.16888109405459367 33.62086439113515 0.022964528732688907 1.0000000000000041e-14 13.999999999999998 -4.217419467742956 ALGTLVSHVTLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALGTLVSHVTLR 12 0 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 12072400.0 2776200.0 4356700.0 4939500.0 False True 3639625.084759041 3706697.342283594 4428407.923029718 1.0 1.0184283424700578 1.2167209039122495 21.795358416392048 -6.925026698617382 0.7865283865825656 0.9963653514466966 1.2527140937916899 0.9954675596954482 0.006604995132425773 0.09530337839867618 0.0909379524726133 0.005848091661389224 0.018456881036743412 1.188429165511957e-07 6.925026698617382 0.2563487423449933 ALGTLVSHVTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALGTLVSHVTLR 12 0 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 9938600.0 2776200.0 2522000.0 4640400.0 False True 3802636.163984036 2410569.7008612696 3544433.0920379153 1.0 0.6339206794729756 0.9320989280037771 21.85856847791494 -9.948472198122174 6.531562465241431 1.0000000293981903 0.7830098037383717 0.4138683497413186 0.12173076021622524 5.208010239805501e-08 8.33586767070669e-09 0.11786531756659174 0.03928843391988162 1.125972547059708e-10 9.948472198122174 -0.21699022565981863 ALGTPNNEVWPEVESLQDYK(ub)NTFPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALGTPNNEVWPEVESLQDYKNTFPK 25 1 P06493;A0A024QZP7;P06493-2 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 13171900.0 0.0 3215100.0 9956800.0 True False 0.0 4498906.196525008 7348815.382402716 0.0 ALGTPNNEVWPEVESLQDYK(ub)NTFPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALGTPNNEVWPEVESLQDYKNTFPK 25 1 P06493;A0A024QZP7;P06493-2 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 12294800.0 0.0 3599100.0 8695700.0 True False 0.0 3579710.933934584 10513930.665625915 0.0 ALGVLAQLIWSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALGVLAQLIWSR 12 0 O75390;B4DJV2;A0A0C4DGI3;H0YIC4 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 0 560254700.0 135310000.0 159900000.0 265044700.0 False True 205275162.48604554 131364595.69559765 212658498.87178126 1.0 0.639943937223909 1.035967996791807 27.612983836492084 -6.667435230734064 1.9470588928432515 0.7696668537330502 1.0343306728627328 0.2675376595215617 0.15303595936375972 0.46699835816428464 3.410850638796042 0.06334112818264366 0.1697629251106247 2.1506253926980114e-07 6.667435230734064 0.2646638191296826 ALGVLAQLIWSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALGVLAQLIWSR 12 0 O75390;B4DJV2;A0A0C4DGI3;H0YIC4 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 0 401041000.0 135310000.0 125181000.0 140550000.0 False True 175161462.35885337 118214567.30705729 114971342.16478392 1.0 0.6748891320904312 0.6563735002922165 27.384110158584534 -13.999999999999998 0.4080434819206343 6.771733986654921 0.6554882331932296 0.9998488287590208 0.001940219315927342 27.996597291179825 0.21151522469643008 143.48661503357636 0.004635542285852051 1.0000000000000041e-14 13.999999999999998 -6.116245753461691 ALGVYVLFPCLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALGVYVLFPCLR 12 0 A0A087WXZ7;K7EIX2;Q6AI08;K7ELA5 A0A087WXZ7 HEATR6 HEAT repeat-containing protein 6 0 14660800.0 3825100.0 4648200.0 6187500.0 False True 5802956.352267925 3818692.3934476394 4964537.912922405 1.0 0.6580598166924363 0.8555187410606927 22.468356646827637 -10.204262940914026 5.3539965499838145 1.0000133539346434 0.7567892788765198 0.6691797125654979 0.08061226831033068 1.2850332566288975e-05 1.909700942047919e-06 0.0780567771185624 0.02601749772213689 6.247943003860291e-11 10.204262940914026 -0.2432240750581236 ALGVYVLFPCLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALGVYVLFPCLR 12 0 A0A087WXZ7;K7EIX2;Q6AI08;K7ELA5 A0A087WXZ7 HEATR6 HEAT repeat-containing protein 6 0 9580700.0 3825100.0 2883300.0 2872300.0 False True 4951667.353993423 2722841.820375603 2349570.872286794 1.0 0.5498838321963782 0.4745009517636338 22.239482968920086 -13.999999999999998 0.2514287636713659 4.15302828859103 0.4445999740767618 0.999545392010845 0.004946697602958984 14.055162356485098 0.15866771952056288 22.401276741181896 0.034514767273099115 1.0000000000000041e-14 13.999999999999998 -3.7084283145142685 ALGYFAVVTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALGYFAVVTGK 11 0 O60313-10;O60313-11;A0A2R8Y3X5;E5KLJ9;C9JMB8;A0A2R8YE78;O60313-2;O60313;O60313-9;O60313-13;A0A2R8YDM2;A0A2R8YFD1;A0A2R8YGE5;A0A2R8Y4Q3;A0A2R8YD53 O60313-10 OPA1 Dynamin-like 120 kDa protein, mitochondrial;Dynamin-like 120 kDa protein, form S1 0 10787400.0 3690600.0 3153000.0 3943800.0 False True 4838412.339821234 2682584.690297737 3535733.407600895 1.0 0.5544349058924669 0.7307631427981044 22.206102293430362 -10.126939009454714 5.217063737167079 1.00000996187068 0.642599024344951 0.8456266916443507 0.07198570127840229 8.341178277697088e-06 1.3958219176321579e-06 0.0697017967636295 0.02323328518452456 7.465535939896445e-11 10.126939009454714 -0.35741093752572894 ALGYFAVVTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALGYFAVVTGK 11 0 O60313-10;O60313-11;A0A2R8Y3X5;E5KLJ9;C9JMB8;A0A2R8YE78;O60313-2;O60313;O60313-9;O60313-13;A0A2R8YDM2;A0A2R8YFD1;A0A2R8YGE5;A0A2R8Y4Q3;A0A2R8YD53 O60313-10 OPA1 Dynamin-like 120 kDa protein, mitochondrial;Dynamin-like 120 kDa protein, form S1 0 8155400.0 3235900.0 1408700.0 3510800.0 False True 3133178.1257421058 1971201.2562734543 2591216.1582576195 1.0 0.6291379478485818 0.8270248464229526 21.579195360680053 -10.047204974506494 4.956458366182284 1.0000051516938324 0.728081397133481 0.7157132742871031 0.08078698805609837 4.599053206271828e-06 8.84260035168586e-07 0.07822314604058941 0.02607388827649623 8.970053338555014e-11 10.047204974506494 -0.27192375456035145 ALGYFAVVTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALGYFAVVTGK 11 0 O60313-10;O60313-11;A0A2R8Y3X5;E5KLJ9;C9JMB8;A0A2R8YE78;O60313-2;O60313;O60313-9;O60313-13;A0A2R8YDM2;A0A2R8YFD1;A0A2R8YGE5;A0A2R8Y4Q3;A0A2R8YD53 O60313-10 OPA1 Dynamin-like 120 kDa protein, mitochondrial;Dynamin-like 120 kDa protein, form S1 0 9548000.0 3690600.0 2290300.0 3567100.0 False True 5055114.55471489 2189106.97299071 2724624.446730546 1.0 0.4330479456591021 0.5389837198030056 22.269312354953254 -9.941217373540177 5.7667496153229685 1.0000004029168592 0.48601583273095783 0.969123628317182 0.043248098694555315 2.2398532856611754e-07 4.122563210793186e-08 0.041874823945092114 0.013958263833066767 1.1449397315424785e-10 9.941217373540177 -0.5139845701859014 ALGYFAVVTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALGYFAVVTGK 11 0 O60313-10;O60313-11;A0A2R8Y3X5;E5KLJ9;C9JMB8;A0A2R8YE78;O60313-2;O60313;O60313-9;O60313-13;A0A2R8YDM2;A0A2R8YFD1;A0A2R8YGE5;A0A2R8Y4Q3;A0A2R8YD53 O60313-10 OPA1 Dynamin-like 120 kDa protein, mitochondrial;Dynamin-like 120 kDa protein, form S1 0 7094500.0 3235900.0 1901000.0 1957600.0 False True 2690794.2246761634 1890758.9356810437 2366925.10908027 1.0 0.7026768967844786 0.8796380962074976 21.35960063611433 -10.277790789056281 5.401611118059261 1.0000262255455392 0.7911574971087816 0.649986954455543 0.07224410714292459 2.281956070867149e-05 3.0511044277086057e-06 0.06995883204587122 0.023316685318841478 5.274839029394929e-11 10.277790789056281 -0.20886872843675763 ALHFVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALHFVFK 7 0 Q9HC38-2;I3L3Q4;Q9HC38;Q9HC38-3;I3L1F4;I3NI27;I3NI24;I3L2C2;I3L277 Q9HC38-2 GLOD4 Glyoxalase domain-containing protein 4 0 58477000.0 17809000.0 16438000.0 24230000.0 False True 23347771.462601356 13985514.474822154 21722912.030571967 1.0 0.599008539090091 0.9304062302206401 24.476781515932824 -9.992936762024241 6.85350061221539 1.0000000294916982 0.764707384655365 0.40196208593962235 0.13529254086772008 6.084776361619474e-08 9.114172220318962e-09 0.13099645502765572 0.04366547980389688 1.0163966804505213e-10 9.992936762024241 -0.23529264483633316 ALHFVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALHFVFK 7 0 Q9HC38-2;I3L3Q4;Q9HC38;Q9HC38-3;I3L1F4;I3NI27;I3NI24;I3L2C2;I3L277 Q9HC38-2 GLOD4 Glyoxalase domain-containing protein 4 0 46921000.0 16121000.0 10441000.0 20359000.0 False True 15609247.679189267 14610145.749095712 15026367.143091856 1.0 0.9359929478583655 0.9626579994066898 23.895897669454442 -10.164737177848732 4.4087540510906615 1.0000105274040827 0.9493254736307796 0.8280430408915662 0.010885961715649964 15252278.993804336 0.11816421789294743 1629.9979805768469 0.0037265542439968826 6.843256556045826e-11 10.164737177848732 -0.050685053773303124 ALHFVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALHFVFK 7 0 Q9HC38-2;I3L3Q4;Q9HC38;Q9HC38-3;I3L1F4;I3NI27;I3NI24;I3L2C2;I3L277 Q9HC38-2 GLOD4 Glyoxalase domain-containing protein 4 0 61702000.0 17809000.0 19769000.0 24124000.0 False True 24393468.570128888 18895540.212659165 18426408.049375605 1.0 0.7746147358394849 0.7553828598176371 24.539991577455716 -13.99999999999993 0.348581038720918 3.747597887176711 0.7526756957242396 0.999751994081475 0.0017489624580578713 20.5193937529846 0.18995730982413156 41.71825311513114 0.005766044811883631 1.0000000000001595e-14 13.99999999999993 -2.9949221914524715 ALHFVFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALHFVFK 7 0 Q9HC38-2;I3L3Q4;Q9HC38;Q9HC38-3;I3L1F4;I3NI27;I3NI24;I3L2C2;I3L277 Q9HC38-2 GLOD4 Glyoxalase domain-containing protein 4 0 35107600.0 16121000.0 8815600.0 10171000.0 False True 13405325.781391416 8768108.613040399 12297709.07460942 1.0 0.6540765033261509 0.9173748758631787 23.676302944888718 -10.353453844598262 5.698060714849996 1.0000443517599134 0.7857256895946638 0.4689451093057635 0.10749111047016235 6.057616114311489e-05 6.8735393073783975e-06 0.10409932762833032 0.03469260672635625 4.431453080254658e-11 10.353453844598262 -0.21431866216524953 ALIAAQYSGAQVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALIAAQYSGAQVR 13 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 449810000.0 139140000.0 146450000.0 164220000.0 False True 182413887.43367672 124600230.85762873 147228089.70947284 1.0 0.6830632941964561 0.807110093320077 27.44264032724748 -10.0862082050393 6.3253732152640705 1.0000004229734665 0.7450866940534385 0.8491834790195653 0.050641893679739085 3.020822796385027e-07 4.366392457349764e-08 0.0490338838120404 0.016344600903502038 8.199583540009787e-11 10.0862082050393 -0.25491372892002795 ALIAAQYSGAQVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALIAAQYSGAQVR 13 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 455896000.0 114300000.0 57316000.0 284280000.0 False True 110671609.06465693 80202577.6989915 209818539.78280628 1.0 0.7246897228370042 1.8958659908904496 26.721709929593196 -6.8447577642452 1.2602126165120324 0.8535086178164275 1.938135475150793 0.9323114409366604 0.13008586132791924 0.16331827873621999 0.5017786728967935 0.08087374525867183 0.18661488424892236 1.4296911727722072e-07 6.8447577642452 1.0846268573343656 ALIAAQYSGAQVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALIAAQYSGAQVR 13 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 477346000.0 93169000.0 286180000.0 97997000.0 False True 141344184.56627294 235108943.06545442 78627849.99638903 1.0 1.6633789624023576 0.5562864170016297 27.074637285564823 -6.744422691929522 1.6703921452974226 1.3926755530908688 0.5549789456030793 0.6246478194261532 0.27871405294081164 0.30988610626535534 1.6993116093709237 0.13190892310955346 0.3221486491077836 1.8012637460018871e-07 6.744422691929522 -0.8376966074877895 ALIAAQYSGAQVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALIAAQYSGAQVR 13 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 534070000.0 139140000.0 160900000.0 234030000.0 False True 190583818.11711657 153790905.97485247 178756933.99914494 1.0 0.8069462953058569 0.9379439228638822 27.505850388770373 -10.176881743581148 4.54173324514588 1.000023297725974 0.8724451090828848 0.5583374038573362 0.05347955751214468 1.2618409744068267e-05 2.2868965757897236e-06 0.05179081408529335 0.017260452966305594 6.654543317321422e-11 10.176881743581148 -0.12757818864308923 ALIAAQYSGAQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALIAAQYSGAQVR 13 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 254782000.0 114300000.0 79810000.0 60672000.0 False True 95045514.34855404 79380047.68895525 73358234.68436764 1.0 0.8351793162784108 0.7718221652770051 26.502115205027472 -13.999999999999998 0.1324057456310275 1.783693896421556 0.6857472724145963 0.999634861211084 0.001837743755142525 11.93377480516386 0.11338793328215545 2.4289368159843625 0.07662429027235972 1.0000000000000041e-14 13.999999999999998 -1.0979466240069597 ALIAAQYSGAQVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALIAAQYSGAQVR 13 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 344552000.0 93169000.0 165610000.0 85773000.0 False True 120609107.13555557 156393657.9171101 70163194.10530062 1.0 1.2966985796631043 0.5817404321420145 26.845763607657272 -6.794001163596521 1.480229947749089 1.1649724518306386 0.5732687118717682 0.8140234686307237 0.1264784466974362 0.22945382432627823 0.9930479517444178 0.06723908384579987 0.1569823289396096 1.606936947573079e-07 6.794001163596521 -0.5917037399588704 ALIAGGGAPEIELALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALIAGGGAPEIELALR 16 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 14035000.0 0.0 14035000.0 0.0 False True 0.0 11941032.708001511 0.0 0.0 ALIAGGGAPEIELALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALIAGGGAPEIELALR 16 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 52558000.0 22207000.0 12372000.0 17979000.0 False True 21502050.940497253 17312204.119127665 13269760.541561402 1.0 0.8051419916656242 0.6171392942135094 24.357970939866544 -6.971562340955414 0.21765871821179605 1.089302958292894 0.32768402507293193 0.9999921375800399 0.0004382569501221418 0.0757989427468642 0.007187975430738369 0.005302114352305854 0.019150744422467298 1.067671522251465e-07 6.971562340955414 -0.761618933219962 ALIAGGGAPEIELALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALIAGGGAPEIELALR 16 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 171905000.0 30336000.0 100910000.0 40659000.0 False True 46021929.85867037 82901822.08657137 32622730.8285272 1.0 1.8013547528570872 0.7088518653761147 25.455818146234144 -6.710066125151376 1.794599714741902 1.4926011672759838 0.7113682576688861 0.46563182507860845 0.3376805971470088 0.3749177486197953 2.3536901498309146 0.14972594857656424 0.38039636717802894 1.9495477413830512e-07 6.710066125151376 -0.7812329096070977 ALIAGGGAPEIELALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALIAGGGAPEIELALR 16 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 24772300.0 0.0 7756300.0 17016000.0 False True 0.0 7413601.019345869 12997171.255520456 0.0 ALIAGGGAPEIELALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALIAGGGAPEIELALR 16 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 48715000.0 22207000.0 13356000.0 13152000.0 False True 18466104.436905857 13284048.577041574 15902022.392022707 1.0 0.7193747128653964 0.8611465643095441 24.13837621530082 -10.181183143456252 4.926509856137129 1.0000193986010213 0.7902606385870257 0.744782316034768 0.05787811598950824 1.2332940658436384e-05 2.049771072806739e-06 0.0560454256970123 0.01868008161121599 6.588959779800623e-11 10.181183143456252 -0.20975876001399563 ALIAGGGAPEIELALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALIAGGGAPEIELALR 16 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 101044000.0 30336000.0 43672000.0 27036000.0 False True 39270550.01195909 41241614.80922671 22115725.41278616 1.0 1.050191932546587 0.5631631185723459 25.226944468326593 -6.881481182275652 1.0715481185732998 1.0317578973020602 0.5276583047012505 0.9748588297185323 0.03468004304018979 0.1263241331392812 0.26445025562922914 0.024897700999851276 0.06043983417098279 1.3137684185393323e-07 6.881481182275652 -0.5040995926008097 ALIEMEK(ub)QQQDQVDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALIEMEKQQQDQVDR 15 1 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 139117000.0 14733000.0 20309000.0 104075000.0 True False 19072158.930847615 19178786.29695422 85134417.89967893 1.0 1.0055907339328083 4.463806022609279 24.1849648273448 -6.90725171810313 0.9142534227497576 0.8834001010842325 4.885405222270934 0.989842327967967 0.16443497528148768 0.10626328727476117 0.14883542931071894 0.13282197632815815 0.3600262058825429 1.238078785155062e-07 6.90725171810313 4.002005121186701 up ALIEVLQPLIAEHQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALIEVLQPLIAEHQAR 16 0 P23381;P23381-2 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 6341300.0 1108600.0 2813300.0 2419400.0 False True 1453385.3356976707 2393566.6061575073 2169063.6965235565 1.0 1.6468905715279698 1.4924216195440954 20.47098582439257 -10.10298678074559 4.825756364649331 0.9999745162406759 1.5696560954681025 0.94773566899337 0.06306168559772535 1.8130072266879263e-05 3.3699214804679807e-06 0.06106207239780149 0.020353071505687517 7.88884129669669e-11 10.10298678074559 0.5696815792274266 ALIEVLQPLIAEHQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALIEVLQPLIAEHQAR 16 0 P23381;P23381-2 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 10399400.0 4384400.0 3069300.0 2945700.0 False True 4245219.621899229 4294887.496188051 2174132.8008942315 1.0 1.011699718439208 0.5121367077639123 22.017407761318946 -6.901537422143198 0.9514889239547346 1.0199029430700568 0.45802908096263256 0.987316024038388 0.026217276336546146 0.11028272614767336 0.17110256302805002 0.02060415447301015 0.054034568516357843 1.254476637872907e-07 6.901537422143198 -0.5618738621074242 ALIEVLQPLIAEHQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALIEVLQPLIAEHQAR 16 0 P23381;P23381-2 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 16926100.0 1108600.0 5085500.0 10732000.0 False True 1518479.3787885248 4860805.794500392 8197322.632477986 1.0 3.2011009582352354 5.3983759983741 20.534195885915462 -6.971146724694806 0.22914716486012052 0.09679026893274423 8.565405335719229 0.9999899978370895 0.005678890825935643 0.07593234897654327 0.007685459550905788 0.0568146486390584 0.21859606000988505 1.0686937642104194e-07 6.971146724694806 8.468615066786484 ALIGK(ub)GHPEFSTNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALIGKGHPEFSTNR 14 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 144138900.0 39844300.0 67222600.0 37072000.0 True False 52236263.15275011 57193250.11164248 33236145.059734352 1.0 1.0948955124220328 0.6362657482321178 25.63854835811301 -6.852739418400511 1.2217579188764174 1.0507848136920352 0.6169350411110659 0.9442039464568174 0.046691216795038105 0.15446784326944712 0.44231808949031676 0.02988154732235634 0.06928150152737403 1.4036556612120916e-07 6.852739418400511 -0.43384977258096935 ALIGK(ub)GHPEFSTNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALIGKGHPEFSTNR 14 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 209854400.0 50848100.0 61859300.0 97147000.0 True False 49233954.89834269 86560041.08198798 71701286.35247037 1.0 1.758137067410397 1.456338141035344 25.553150298219702 -10.229195630052788 4.886417192282187 0.9998960350894078 1.6072376042237893 0.8436974493489521 0.12320889575961852 0.00013957104483003233 2.2016403812776393e-05 0.11931675842526376 0.03976550011468161 5.899352811064983e-11 10.229195630052788 0.6073415691343814 ALIGK(ub)GHPEFSTNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALIGKGHPEFSTNR 14 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 193708500.0 66924400.0 58115200.0 68668900.0 True False 101529207.62900843 47744088.50386998 55096461.81635193 1.0 0.47024978938404294 0.54266612635919 26.597319576557815 -10.57781402584547 6.414326825600603 1.0009666857892983 0.5064579578717892 0.98410979020426 0.029563845771758815 0.0004094116228550045 2.6947133316075005e-05 0.028675272826992077 0.009541690193655538 2.6435405353856125e-11 10.57781402584547 -0.4945087279175091 ALIGK(ub)GHPEFSTNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALIGKGHPEFSTNR 14 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 117798200.0 39844300.0 41308900.0 36645000.0 True False 54575814.46172082 39483736.20773522 27990205.727465183 1.0 0.7234658171785764 0.5128683099561869 25.7017584196359 -7.277061516487253 0.14257009607117616 1.2945270940787137 1.985053656261541e-14 0.9999957036399149 0.00041342893938193934 0.1045268803839609 0.00785483231438023 0.02325616587749173 0.04472421214866069 5.283704044199375e-08 7.277061516487253 -1.294527094078694 ALIGK(ub)GHPEFSTNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALIGKGHPEFSTNR 14 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 204096400.0 50848100.0 124527000.0 28721300.0 True False 42282448.10277078 123856148.33432566 34726791.03771309 1.0 2.9292567931091322 0.8213051182208494 25.333555573653978 -6.665940824839507 1.951620423179951 2.235690292640033 0.8299310696474691 0.2612689720976368 0.8202771470930104 0.4704948292812239 3.450793580145993 0.33883370773552957 0.9101446797304403 2.158038434465756e-07 6.665940824839507 -1.405759222992564 ALIGK(ub)GHPEFSTNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALIGKGHPEFSTNR 14 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 156429700.0 66924400.0 63727000.0 25778300.0 True False 86634955.0771478 60180536.42946484 21086913.90769441 1.0 0.694644977606031 0.24339960572400213 26.368445898650265 -7.2056199650582515 0.403265915048409 1.0285615660588157 3.0806143682059656e-18 0.9996653641103579 0.005685277611487911 0.08926906640788711 0.02602726932613012 0.009110374764988926 0.04461610317739723 6.228450753219994e-08 7.2056199650582515 -1.0285615660588157 down ALILGFMAGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALILGFMAGSR 11 0 A0A0C4DFX9;Q9H3P2;H0Y3X6;Q9H3P2-7 A0A0C4DFX9 NELFA Negative elongation factor A 0 20193500.0 4564200.0 6612600.0 9016700.0 False True 6924225.087715689 5432529.865520379 7234545.292839997 1.0 0.7845686407794952 1.0448165969755734 22.723221192880985 -6.686917585992795 1.877734076089569 0.8645485081579519 1.043876868526583 0.35592565773552454 0.09117021518160563 0.4232982408325118 2.891318550959911 0.03888065975942337 0.10162942613623888 2.0562807696262884e-07 6.686917585992795 0.17932836036863098 ALILGFMAGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALILGFMAGSR 11 0 A0A0C4DFX9;Q9H3P2;H0Y3X6;Q9H3P2-7 A0A0C4DFX9 NELFA Negative elongation factor A 0 14875200.0 4564200.0 5281000.0 5030000.0 False True 5908446.873832528 4987107.707627912 4114591.612158402 1.0 0.8440640686328137 0.6963914037005571 22.494347514973434 -6.971784828723572 0.2112499584285696 1.0760929072483811 0.46023429576326863 0.9999931573850523 0.0003242158574817826 0.07572770481609432 0.006918281744373056 0.004378544534159977 0.015258531541335326 1.067124697394386e-07 6.971784828723572 -0.6158586114851126 ALILVGGYGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALILVGGYGTR 11 0 Q9Y5P6;Q9Y5P6-2 Q9Y5P6 GMPPB Mannose-1-phosphate guanyltransferase beta 0 34567000.0 11848000.0 10701000.0 12018000.0 False True 15532842.736195225 9104452.5121713 10774492.644796275 1.0 0.5861420647075604 0.6936587737213832 23.88881855228181 -10.06731923415811 7.3064626483404975 1.0000000551855577 0.6399004192144759 0.937329893555764 0.043893512651193914 3.9442089711598886e-08 5.027210180310397e-09 0.042499717209068436 0.014166570292051532 8.564080992035368e-11 10.06731923415811 -0.36009963597108174 ALILVGGYGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALILVGGYGTR 11 0 Q9Y5P6;Q9Y5P6-2 Q9Y5P6 GMPPB Mannose-1-phosphate guanyltransferase beta 0 26412100.0 10846000.0 3968100.0 11598000.0 False True 10501699.66680025 5552583.023368135 8560135.867458088 1.0 0.5287318433721638 0.8151190892003738 23.3241195066192 -10.377560535888975 5.8655680423980465 1.0000732843923592 0.6719254662862693 0.6363308036081472 0.1169171035200223 0.00011207216037093216 1.189311827690739e-05 0.11322967357215495 0.03773483290165435 4.1921755828073154e-11 10.377560535888975 -0.32814781810608995 ALILVGGYGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALILVGGYGTR 11 0 Q9Y5P6;Q9Y5P6-2 Q9Y5P6 GMPPB Mannose-1-phosphate guanyltransferase beta 0 30002200.0 7705700.0 12564000.0 9732500.0 False True 11690110.262129351 10321856.03701994 7808867.109093705 1.0 0.8829562600840529 0.6679891749516588 23.478785201769472 -6.9616764475594275 0.41112504413916334 1.0104604002442832 0.5324927522203072 0.9998274090178935 0.00180630222039833 0.07910759724475969 0.018958016170762867 0.0027690067070891768 0.01794165848596717 1.0922537701376604e-07 6.9616764475594275 -0.47796764802397596 ALILVGGYGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALILVGGYGTR 11 0 Q9Y5P6;Q9Y5P6-2 Q9Y5P6 GMPPB Mannose-1-phosphate guanyltransferase beta 0 34107700.0 11848000.0 9691700.0 12568000.0 False True 16228525.780160984 9263488.647833921 9599697.246084921 1.0 0.5708151666590894 0.5915323040507068 23.9520286138047 -10.109656306572143 4.87417484340381 1.0000191576870805 0.5811737353523154 0.9981682891805425 0.00845773593234823 1.7608353303487607e-06 3.216372856502561e-07 0.008189541723271705 0.002729722533113389 7.768616688239081e-11 10.109656306572143 -0.41884542233476507 ALILVGGYGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALILVGGYGTR 11 0 Q9Y5P6;Q9Y5P6-2 Q9Y5P6 GMPPB Mannose-1-phosphate guanyltransferase beta 0 39969700.0 7705700.0 20020000.0 12244000.0 False True 9975180.552055411 18905869.401005633 10015717.634049198 1.0 1.895290947601949 1.0040637943125184 23.249911523861922 -6.645111310131617 2.0258871261695965 1.5831785580959563 1.0077879275763273 0.17453708765869402 0.3825809327413493 0.5205953311760146 4.089583934832143 0.15345147743311724 0.4237170447368899 2.2640639512558343e-07 6.645111310131617 -0.575390630519629 ALIPLALEGTDVGQTK(ub)AAQALAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALIPLALEGTDVGQTKAAQALAK 23 1 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 1 10034400.0 1843300.0 5122500.0 3068600.0 True False 2416584.1505425903 4358242.967348605 2751090.70808969 1.0 1.803472461892154 1.1384212329092673 21.20453780264007 -10.1272244061748 4.487310337573191 0.9999480977498971 1.4709468472049472 0.40069848405859576 0.2715060273744242 189501083.33719692 13.351523195558512 111780.52573902176 0.0929437347964514 7.460631572841607e-11 10.1272244061748 0.47099874945505005 ALIPLALEGTDVGQTK(ub)AAQALAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALIPLALEGTDVGQTKAAQALAK 23 1 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 1 25217100.0 5976700.0 6440400.0 12800000.0 True False 5786972.929980174 9012085.306242313 9447296.008231042 1.0 1.5573055922819374 1.6325108346866604 22.464377464879608 -11.561679388471815 0.3381347641385376 7.595173062291176e-15 1.64622627111458 0.999493426331979 0.006349682170680406 4.060584224132636 0.1758998721141441 2.9704409052076852 0.02335850853633593 2.743598846079957e-12 11.561679388471815 1.6462262711145725 ALIPLALEGTDVGQTK(ub)AAQALAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALIPLALEGTDVGQTKAAQALAK 23 1 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 1 70485000.0 12361000.0 17619000.0 40505000.0 True False 18752540.710147154 14474751.792124663 32499168.996027827 1.0 0.7718821687075318 1.733054176410467 24.160582738305823 -6.84412247436455 1.2632826931624517 0.8786402249557659 1.7673015576615099 0.9312835210291557 0.1074894038374958 0.16404277809940784 0.5067710598035327 0.06667311971115208 0.15379980015191713 1.431784068279706e-07 6.84412247436455 0.888661332705744 ALIPLALEGTDVGQTK(ub)AAQALAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALIPLALEGTDVGQTKAAQALAK 23 1 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 1 16805300.0 1843300.0 7538500.0 7423500.0 True False 2524817.8233094774 7205424.143514151 5670222.191781623 1.0 2.85383922633651 2.245794583448091 21.26774786416296 -10.129885649793753 5.2164444502436025 0.9999551897652011 2.5498169048937056 0.8965039838205235 0.24823318598981398 0.00012936770870531744 2.1579070391852277e-05 0.24035762559179424 0.08011691627550667 7.415054547871118e-11 10.129885649793753 1.5498617151285043 ALIPLALEGTDVGQTK(ub)AAQALAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALIPLALEGTDVGQTKAAQALAK 23 1 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 1 29946700.0 5976700.0 14227000.0 9743000.0 True False 4969890.86270343 14150356.32716162 11780216.253457822 1.0 2.8472167132186015 2.370316890027206 22.244782740313884 -10.026137575689658 4.836117292261458 0.9999714617034939 2.6087668016579904 0.9381684384931319 0.19469353765178368 67266214.4633666 3.012364695323787 23512.047306063392 0.06664877646585521 9.415912722427634e-11 10.026137575689658 1.6087953399544963 ALIPLALEGTDVGQTK(ub)AAQALAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALIPLALEGTDVGQTKAAQALAK 23 1 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 1 47922300.0 12361000.0 9724300.0 25837000.0 True False 16001558.171737408 9183134.156653298 21134931.11000728 1.0 0.5738899960925629 1.3208045668537856 23.931709060398273 -6.751946983189575 1.642475314201779 0.750034229936612 1.3225278621380543 0.6573823656648066 0.17907468320400852 0.2966564579930029 1.5751343650349499 0.08610290263194093 0.2086225026020734 1.7703250588283608e-07 6.751946983189575 0.5724936322014423 ALIVVQQGMTPSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALIVVQQGMTPSAK 14 0 P19388;A0A087WVZ9;A0A0A0MQR7;A0A087WWX0;A0A087WVN5 P19388 POLR2E DNA-directed RNA polymerases I, II, and III subunit RPABC1 0 13048600.0 4238000.0 3981700.0 4828900.0 False True 5556059.040850374 3387645.8805450355 4329251.750079607 1.0 0.6097210010976674 0.7791946986612655 22.405630499365127 -10.139655880990246 4.922646964871755 1.0000173189864585 0.6944578498798933 0.8125190422672575 0.06918734731309584 1.3500537028463179e-05 2.3595652465865904e-06 0.06699425644883503 0.022330120325391965 7.250102040193276e-11 10.139655880990246 -0.3055594691065652 ALIVVQQGMTPSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALIVVQQGMTPSAK 14 0 P19388;A0A087WVZ9;A0A0A0MQR7;A0A087WWX0;A0A087WVN5 P19388 POLR2E DNA-directed RNA polymerases I, II, and III subunit RPABC1 0 8470000.0 2673700.0 1040400.0 4755900.0 False True 2588824.8570093894 1455837.145614327 3510187.116058281 1.0 0.5623544372546353 1.3558998039416423 21.303865934534745 -6.756980718380865 1.6237753539814659 0.7448386591857268 1.358379697759138 0.6785378083128351 0.18400424156570355 0.28802335324605294 1.4960040533746999 0.08943892434724061 0.21558665102866917 1.7499243792880128e-07 6.756980718380865 0.6135410385734112 ALIVVQQGMTPSAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALIVVQQGMTPSAK 14 0 P19388;A0A087WVZ9;A0A0A0MQR7;A0A087WWX0;A0A087WVN5 P19388 POLR2E DNA-directed RNA polymerases I, II, and III subunit RPABC1 0 19840900.0 2518900.0 12492000.0 4830000.0 False True 3821355.456256746 10262704.999558512 3875348.3829357955 1.0 2.6856190472297667 1.0141292604933274 21.86565303040288 -6.644230789468752 2.029285095229759 2.0987403153751356 1.0211343995528706 0.1710143378271065 0.7204672051524811 0.5227580154740119 4.119391558880652 0.28861381003908465 0.7978034305224538 2.2686589380242316e-07 6.644230789468752 -1.077605915822265 ALIVVQQGMTPSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALIVVQQGMTPSAK 14 0 P19388;A0A087WVZ9;A0A0A0MQR7;A0A087WWX0;A0A087WVN5 P19388 POLR2E DNA-directed RNA polymerases I, II, and III subunit RPABC1 0 11983200.0 4238000.0 3665400.0 4079800.0 False True 5804903.127643662 3503450.508143099 3116235.2661184953 1.0 0.6035329842903385 0.5368281257405658 22.46884056088802 -13.999999999999998 0.2507733873925548 3.7680261485567477 0.510203776929518 0.9995441470053487 0.004364950081967394 14.028767234310834 0.15846057755013143 19.5702099001409 0.030652128430490654 1.0000000000000041e-14 13.999999999999998 -3.2578223716272294 ALIVVQQGMTPSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALIVVQQGMTPSAK 14 0 P19388;A0A087WVZ9;A0A0A0MQR7;A0A087WWX0;A0A087WVN5 P19388 POLR2E DNA-directed RNA polymerases I, II, and III subunit RPABC1 0 5670800.0 2673700.0 1373900.0 1623200.0 False True 2223300.014993254 1366498.5280022018 1962603.6151711731 1.0 0.6146262397278615 0.882743490278404 21.08427120996902 -10.089283026393984 5.5742645548646745 1.000002106887267 0.7486848650030671 0.5394798032664334 0.10945840918136195 2.866014199309527e-06 4.6832510148345e-07 0.10598353643842119 0.035327549655114 8.141735204328492e-11 10.089283026393984 -0.2513172418842 ALIVVQQGMTPSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALIVVQQGMTPSAK 14 0 P19388;A0A087WVZ9;A0A0A0MQR7;A0A087WWX0;A0A087WVN5 P19388 POLR2E DNA-directed RNA polymerases I, II, and III subunit RPABC1 0 11812500.0 2518900.0 4372300.0 4921300.0 False True 3260765.7049421025 4128977.6614394058 4025673.8968022107 1.0 1.2662601471738426 1.2345793169686474 21.636779352495328 -10.368049260456207 5.537859827950299 0.9999207565239817 1.2504197320710284 0.9881386195010858 0.012933644771755827 1.2659468647187465e-05 1.4446050149806766e-06 0.012526897906909362 0.004174315900563118 4.284999144415668e-11 10.368049260456207 0.2504989755470467 ALK(ub)DPNAFLFDHLLTLKPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALKDPNAFLFDHLLTLKPVK 20 2 Q7L2H7;J3KNJ2;Q7L2H7-2;H0YCQ8 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 1 2728690.0 590100.0 967890.0 1170700.0 True False 571367.5985044094 1354373.524479671 864058.5497528195 1.0 2.370406596427289 1.5122638245755395 19.124059699716316 -10.085638076389706 5.303911704001086 0.9999866939436737 1.9413352105023658 0.6160320030961676 0.35033531958572894 5.5123397263420104e-05 9.503595240950241e-06 0.33921550227937536 0.11307023819483432 8.210354773604606e-11 10.085638076389706 0.9413485165586921 ALK(ub)DPNAFLFDHLLTLKPVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALKDPNAFLFDHLLTLKPVK 20 2 Q7L2H7;J3KNJ2;Q7L2H7-2;H0YCQ8 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 1 3803400.0 590100.0 1743000.0 1470300.0 True False 490694.29586248205 1733610.1130415883 1777732.932100896 1.0 3.532973844732517 3.6228930050556545 18.904464975150592 -10.376977969161665 0.6681636025326965 2.5913293844601836e-20 3.6088268905948713 0.9998736282498585 0.013667480208174335 1.7258085336049485 0.3327669065749482 3.136714513888436 0.014431772602991923 4.197802780144456e-11 10.376977969161665 3.6088268905948713 ALK(ub)EFVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALKEFVAK 8 1 Q13564;Q13564-4;Q13564-3;Q13564-2 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 1 2840300.0 0.0 0.0 2840300.0 True False 0.0 0.0 2096340.2228264548 0.0 ALK(ub)EFVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALKEFVAK 8 1 Q13564;Q13564-4;Q13564-3;Q13564-2 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 1 3444100.0 0.0 2055300.0 1388800.0 True False 0.0 2044227.6909548922 1679191.6589143234 0.0 ALK(ub)ETEGGCPDTTFIEDAVHVLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALKETEGGCPDTTFIEDAVHVLLK 24 1 Q9P2G1 Q9P2G1 ANKIB1 Ankyrin repeat and IBR domain-containing protein 1 1 33555200.0 6215900.0 8947300.0 18392000.0 True False 9429974.743160246 7350584.409426034 14756813.13850003 1.0 0.7794914206697705 1.5648836333526184 23.168822476177223 -6.831738222980106 1.320034503069152 0.8823068499585874 1.5867917515286236 0.9093209804450583 0.09959852600216496 0.17867744681211647 0.6082768850425976 0.059229013359552544 0.1363063595811172 1.4732002267224373e-07 6.831738222980106 0.7044849015700362 ALK(ub)ETEGGCPDTTFIEDAVHVLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALKETEGGCPDTTFIEDAVHVLLK 24 1 Q9P2G1 Q9P2G1 ANKIB1 Ankyrin repeat and IBR domain-containing protein 1 1 23887800.0 6215900.0 7049900.0 10622000.0 True False 8046605.083707033 6657566.8676398415 8688904.990923764 1.0 0.8273758682553279 1.079822471779717 22.939948798269672 -6.72261908847065 1.7497348567166209 0.8952734892906374 1.0794923682646655 0.5249148253815055 0.07261849427459016 0.3502552930223535 2.0970243618383444 0.03293477332359526 0.08242986884332772 1.894004085750098e-07 6.72261908847065 0.1842188789740281 ALK(ub)GQFNFDHPDAFDNELILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALKGQFNFDHPDAFDNELILK 21 1 Q9BZX2;A0A2R8Y653 Q9BZX2 UCK2 Uridine-cytidine kinase 2 1 45877400.0 11941000.0 28129700.0 5806700.0 True False 15654766.63680848 23932858.40871181 5205878.385799508 1.0 1.5287904932699128 0.33254270131112124 23.90009866681597 -6.786524631604217 1.5100708032764543 1.2968736224884114 0.3209863061993638 0.7899327102748082 0.22433403697698162 0.24055562542767808 1.083675470092765 0.11695556717082663 0.2745447834080799 1.634840426294524e-07 6.786524631604217 -0.9758873162890476 down ALK(ub)GQFNFDHPDAFDNELILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALKGQFNFDHPDAFDNELILK 21 1 Q9BZX2;A0A2R8Y653 Q9BZX2 UCK2 Uridine-cytidine kinase 2 1 531327000.0 231402000.0 172633000.0 127292000.0 True False 224056270.17305094 241566257.16920236 93950406.52185509 1.0 1.0781499530570045 0.4193161229065004 27.73928585970666 -6.8772967523272115 1.094708377808063 1.0469086879206206 0.3749692889995894 0.9714412828432042 0.04966610218033725 0.13005425174393626 0.2869535793870852 0.035028418598686356 0.08415945411852327 1.3264877622418892e-07 6.8772967523272115 -0.6719393989210312 down ALK(ub)GQFNFDHPDAFDNELILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALKGQFNFDHPDAFDNELILK 21 1 Q9BZX2;A0A2R8Y653 Q9BZX2 UCK2 Uridine-cytidine kinase 2 1 1234985000.0 441190000.0 437140000.0 356655000.0 True False 669317485.3094265 359128951.6095905 286161982.9225604 1.0 0.5365599427655242 0.4275429660862173 29.318115462987784 -13.999999999999993 0.20330288195603843 3.609212329039244 0.35900268289207987 0.9994873688854767 0.00561927450059884 12.598119597147125 0.14295443887464387 13.089663372060972 0.06774478677020196 1.0000000000000164e-14 13.999999999999993 -3.250209646147164 ALK(ub)GQFNFDHPDAFDNELILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALKGQFNFDHPDAFDNELILK 21 1 Q9BZX2;A0A2R8Y653 Q9BZX2 UCK2 Uridine-cytidine kinase 2 1 35318700.0 11941000.0 20704700.0 2673000.0 True False 16355910.393391456 19789897.892713048 2041692.4521630316 1.0 1.2099539198202676 0.12482903140555048 23.963308728338863 -6.856524422838004 1.2030695184355993 1.1130224162658664 0.07563406839964522 0.9492956933331576 0.10581685155416076 0.15041376568237755 0.41565984387847127 0.06869034226427245 0.15977811800446554 1.3914755420951312e-07 6.856524422838004 -1.0373883478662211 down ALK(ub)GQFNFDHPDAFDNELILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALKGQFNFDHPDAFDNELILK 21 1 Q9BZX2;A0A2R8Y653 Q9BZX2 UCK2 Uridine-cytidine kinase 2 1 424300200.0 231402000.0 166535000.0 26363200.0 True False 192421015.84675494 165637842.9003906 31875623.23033557 1.0 0.8608095231775795 0.16565562285421814 27.519691135140935 -6.969415684001536 0.6789126754407744 1.0064142252345827 3.134124475236868e-18 0.998135384536054 0.015759284102561128 0.08223495897143598 0.056079270255401555 0.015372232451795526 0.05557973332670454 1.0729619375548014e-07 6.969415684001536 -1.0064142252345827 down ALK(ub)GQFNFDHPDAFDNELILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALKGQFNFDHPDAFDNELILK 21 1 Q9BZX2;A0A2R8Y653 Q9BZX2 UCK2 Uridine-cytidine kinase 2 1 1217816000.0 441190000.0 431650000.0 344976000.0 True False 571129152.1550704 407628298.04915446 282193907.7526752 1.0 0.7137235010873286 0.4940982380042389 29.089241785080233 -7.326128737433417 0.15074708364116154 1.2792794024689078 4.365023432086307e-12 0.9999929222318424 0.0005510203561291693 0.11192490722145074 0.00942106153825701 0.025722511492149443 0.049663795002829976 4.719231288759145e-08 7.326128737433417 -1.2792794024645429 down ALK(ub)IQTSGEPDVAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALKIQTSGEPDVAER 15 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 7261100.0 2848700.0 1801000.0 2611400.0 True False 2758269.577799544 2520148.692090925 1927395.9996792614 1.0 0.9136701910410858 0.6987699879635673 21.395332033989177 -6.955553541154661 0.4941302271426298 1.004531608497803 0.598731738063385 0.9995680994750844 0.002632174899530137 0.0813294245860258 0.02730431560547796 0.003122037865339398 0.017724838475664084 1.1077619886628725e-07 6.955553541154661 -0.4057998704344181 ALK(ub)IQTSGEPDVAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALKIQTSGEPDVAER 15 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 9128500.0 2848700.0 3515300.0 2764500.0 True False 2368820.268807749 3496362.381167583 3342544.168396197 1.0 1.4759931039121585 1.4110585815269696 21.175737309423454 -10.5865464240856 6.258703827386637 0.998853867193983 1.4435258427195188 0.9841784661790772 0.026509407755840837 0.00042493619590280613 2.807145596196197e-05 0.02572691264918777 0.008555874563016099 2.590917449374964e-11 10.5865464240856 0.44467197552553583 ALK(ub)IQTSGEPDVAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALKIQTSGEPDVAER 15 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 19583100.0 5172500.0 4469500.0 9941100.0 True False 6695903.215218167 4220768.395993737 8131921.804299777 1.0 0.6303508668406306 1.214462267886114 22.674847244175705 -6.735692944637786 1.7025062289089636 0.7789687546623517 1.2144901185676042 0.5854306056057619 0.155334771008079 0.3256685717451362 1.8517272125993272 0.07223066574918 0.17808968659275048 1.837837273839131e-07 6.735692944637786 0.43552136390525253 ALK(ub)LNSNEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALKLNSNEAR 10 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 5731300.0 1783500.0 2457300.0 1490500.0 True False 2338185.7714385665 2090680.4184803779 1336277.3578855745 1.0 0.8941464121535941 0.5715017917774049 21.15695812745977 -6.951092969909776 0.5467121908295554 1.004551530191417 0.4460245035034021 0.9992842914845373 0.004875515793801904 0.08304979276248715 0.0341687268652252 0.005314409818146952 0.026749923737967505 1.1191982697844248e-07 6.951092969909776 -0.5585270266880149 ALK(ub)LNSNEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALKLNSNEAR 10 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 5111600.0 1105700.0 2007600.0 1998300.0 True False 1070600.15872958 2809245.1494956957 1474885.2822850079 1.0 2.6239909704751643 1.377624755852054 20.029988340986936 -6.579228267738562 2.270853355276542 2.106420378270739 1.3807291721774897 0.0 0.7056510849568757 0.7014682112640104 6.8033379512845915 0.2611146874847663 0.7885603804371699 2.6349460786103734e-07 6.579228267738562 -0.7256912060932494 ALK(ub)LNSNEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALKLNSNEAR 10 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 4360200.0 1783500.0 1362700.0 1214000.0 True False 2442908.147275242 1302491.4081537079 927278.203114823 1.0 0.5331724852637107 0.3795796432825711 21.22016818898266 -13.999999999999998 0.15539169099264385 3.278101282019419 0.2206409649835331 0.9995492526941084 0.005601248783506485 11.982104230032101 0.12440013376099683 8.231743293033688 0.14406678807288176 1.0000000000000041e-14 13.999999999999998 -3.057460317035886 ALK(ub)LNSNEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALKLNSNEAR 10 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 5970900.0 1105700.0 2826600.0 2038600.0 True False 919438.5408153636 2811372.544763828 2464861.8345785816 1.0 3.0577057845222435 2.6808337100952144 19.810393616421212 -10.163228515414366 5.219308377663975 0.9999197761573024 2.8692697473098483 0.9704155848354118 0.15385738011231334 0.0001436333852171305 2.3027255239656543e-05 0.14897801913937841 0.049657255904944915 6.867070160571849e-11 10.163228515414366 1.8693499711525459 ALK(ub)MIVDPVEPHGEMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ALKMIVDPVEPHGEMK 16 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 38469700.0 10688600.0 14043600.0 13737500.0 True False 14012858.10854964 11948349.621524043 12316075.279404959 1.0 0.8526704209067827 0.8789124377053796 23.740247906810627 -10.344530808917582 5.224172202897324 1.0000505236125459 0.865791429306096 0.9721248414301347 0.010713258496382135 6.306674957827816e-06 7.912943719370384e-07 0.010376969080094531 0.0034576893116708 4.52344371814701e-11 10.344530808917582 -0.1342590943064499 ALK(ub)MIVDPVEPHGEMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALKMIVDPVEPHGEMK 16 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 31898890.0 3425500.0 12315400.0 16157990.0 True False 3316759.377523904 17233003.44396257 11925727.689690406 1.0 5.195735198863811 3.5955962830784083 21.6613429213823 -9.393234554045025 9.328623899099368 1.0000097169232316 4.395665740971147 0.8572336143364762 0.6532539768983188 0.0 0.0 0.6325104433317907 0.2108368144439302 4.043574470820259e-10 9.393234554045025 3.3956560240479154 ALK(ub)MIVDPVEPHGEMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALKMIVDPVEPHGEMK 16 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 76000300.0 17531300.0 17505000.0 40964000.0 True False 26596263.80970815 14381095.982810762 32867447.44484098 1.0 0.5407186545337764 1.2357919022010802 24.664720257239157 -6.728570254454148 1.7290256540671873 0.7231580852084395 1.2352269122158344 0.5523801337281182 0.1930930970202161 0.33891821700552455 1.9844141223991096 0.0885351329820383 0.22000158703336922 1.8682274355263254e-07 6.728570254454148 0.5120688270073949 ALK(ub)MIVDPVEPHGEMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALKMIVDPVEPHGEMK 16 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 43599800.0 8007500.0 14440300.0 21152000.0 True False 10968089.144550899 13802279.798313644 16156333.239114275 1.0 1.2584033204335152 1.4730308102155578 23.386808866177898 -6.973258043993414 0.1624891031795102 0.7900493939373883 1.9470923651577363 0.9999979251368166 0.0002785058084505305 0.0752589420528276 0.005028626111354371 0.009701423276038759 0.025522942051529503 1.0635109260298452e-07 6.973258043993414 1.157042971220348 ALK(ub)MIVDPVEPHGEMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ALKMIVDPVEPHGEMK 16 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 47066100.0 6790200.0 23447800.0 16828100.0 True False 5646352.156863964 23321482.047376115 20346777.90565677 1.0 4.130362648214468 3.6035261953901148 22.42888768024382 -9.51405151350464 8.325983226216357 0.9999998420371955 3.866944421802371 0.975299133505711 0.21508008121989697 0.0 0.0 0.20825039316626104 0.06941679772208699 3.061600262801261e-10 9.51405151350464 2.8669445797651756 ALK(ub)MIVDPVEPHGEMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALKMIVDPVEPHGEMK 16 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 89527700.0 17531300.0 24291400.0 47705000.0 True False 22694613.443587065 22939562.236143243 39023179.49463553 1.0 1.0107932568741502 1.7194908206582613 24.435846579331606 -6.910213164749929 0.894285223655657 0.978204815847748 1.8114958298495871 0.9910016388568459 0.031935090349996344 0.1042772842562036 0.13800532865988213 0.026173243166031975 0.07235683677121815 1.2296650661919803e-07 6.910213164749929 0.8332910140018391 ALK(ub)TQNFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALKTQNFK 8 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 1 4706580.0 671580.0 1122600.0 2912400.0 True False 919881.2747670925 1072999.8200582312 2224551.1027608006 1.0 1.1664546822413655 2.4183024089973366 19.81108814500022 -6.931264884058105 0.7363385837279077 0.9818287799868487 2.683776550076097 0.9967810270843276 0.035914931921482 0.09198625177212871 0.07450219516617873 0.03296996972678558 0.1124930104931135 1.171480640381272e-07 6.931264884058105 1.7019477700892485 up ALK(ub)VLDNYLTSPLPEEVDETSAEDEGVSQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALKVLDNYLTSPLPEEVDETSAEDEGVSQR 30 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 16387000.0 8618800.0 3985200.0 3783000.0 True False 8345200.9116925895 5576511.142543448 2792118.8124326603 1.0 0.6682297048990291 0.3345777821263212 22.992515352382796 -7.284131274741651 0.272603686157561 1.0966895152493106 3.5687615378678045e-12 0.9999194897456739 0.0024375112689981383 0.1028585635480532 0.017572885640705613 0.01387816198616895 0.046680095816604095 5.1983884043986044e-08 7.284131274741651 -1.0966895152457419 down ALK(ub)VLDNYLTSPLPEEVDETSAEDEGVSQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALKVLDNYLTSPLPEEVDETSAEDEGVSQR 30 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 36666200.0 11699000.0 9874200.0 15093000.0 True False 17748238.311464414 8112071.862523266 12109861.934503099 1.0 0.45706349667861407 0.6823134624398622 24.08117249415572 -10.27182333822193 5.638738211104662 1.000033712068919 0.5696884795592325 0.8295270950545344 0.09195791344910044 3.897552976214852e-05 5.033279638693163e-06 0.08904482464966623 0.029679288945025136 5.347818530660523e-11 10.27182333822193 -0.43034523250968637 ALK(ub)VLDNYLTSPLPEEVDETSAEDEGVSQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALKVLDNYLTSPLPEEVDETSAEDEGVSQR 30 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 36067600.0 11699000.0 8220600.0 16148000.0 True False 15144586.121766523 7763116.383511833 13209229.692471951 1.0 0.5126001015210518 0.872208034360676 23.85229881624817 -9.887453223208228 5.851120627482383 1.0000000951338759 0.6924040679405451 0.4938071595375705 0.14680932382015574 1.8220048901458573e-07 3.475296320750525e-08 0.14214756103655415 0.047382505518453744 1.2958262602641132e-10 9.887453223208228 -0.3075960271933308 ALK(ub)YEPTNVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALKYEPTNVR 10 1 Q9Y5Q9;A0A494C1S7;Q9Y5Q9-2 Q9Y5Q9 GTF3C3 General transcription factor 3C polypeptide 3 1 4802300.0 1467600.0 1980000.0 1354700.0 True False 1924037.812258618 1684591.7179795506 1214528.6391999926 1.0 0.8755502138505361 0.6312394857636732 20.87570572135414 -6.960407199107918 0.42965701225891134 1.009739772594056 0.48768632080212393 0.9997850020223202 0.0022459501725895356 0.07955599826531345 0.020596265881278702 0.003184710336669224 0.020286971542226 1.0954506083823153e-07 6.960407199107918 -0.5220534517919321 ALK(ub)YEPTNVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALKYEPTNVR 10 1 Q9Y5Q9;A0A494C1S7;Q9Y5Q9-2 Q9Y5Q9 GTF3C3 General transcription factor 3C polypeptide 3 1 6008000.0 1586700.0 1603700.0 2817600.0 True False 1536331.0770156672 2244065.773185016 2079586.0338118551 1.0 1.4606654820418838 1.3536053946467477 20.55105771747912 -10.037692347418643 4.885294720797481 0.999991898210529 1.407135438349658 0.9506961988418525 0.043707097674423885 3.85690328986999e-06 7.596799976430364e-07 0.04232005685394911 0.014106405114379146 9.168697672248053e-11 10.037692347418643 0.4071435401391289 ALK(ub)YEPTNVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALKYEPTNVR 10 1 Q9Y5Q9;A0A494C1S7;Q9Y5Q9-2 Q9Y5Q9 GTF3C3 General transcription factor 3C polypeptide 3 1 4966400.0 1467600.0 1742700.0 1756100.0 True False 2010211.3803987387 1665701.7516617517 1341345.3480147792 1.0 0.8286201978079284 0.6672658214424766 20.938915782877032 -6.9718540936592674 0.20922364256159898 1.0853196288245834 0.40606595881354685 0.9999934568470185 0.0003474730180240749 0.07570563019615453 0.006834135225848924 0.004861738749249914 0.01675038878542913 1.0669545169460998e-07 6.9718540936592674 -0.6792536700110365 ALK(ub)YEPTNVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALKYEPTNVR 10 1 Q9Y5Q9;A0A494C1S7;Q9Y5Q9-2 Q9Y5Q9 GTF3C3 General transcription factor 3C polypeptide 3 1 6662200.0 1586700.0 3923500.0 1152000.0 True False 1319411.3527283499 3902363.326746227 1392877.8737538166 1.0 2.9576548046799127 1.0556812861080427 20.331462992913398 -6.639482363418714 2.046451114364377 2.280728008402555 1.0636121252744801 0.15252411350631678 0.837738446723053 0.5347216609466716 4.279381092263784 0.33344581734555095 0.9275819349561765 2.2935997710218757e-07 6.639482363418714 -1.2171158831280748 ALKDPNAFLFDHLLTLKPVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALKDPNAFLFDHLLTLKPVK 20 2 Q7L2H7;J3KNJ2;Q7L2H7-2;H0YCQ8 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 0 13668340.0 1961240.0 5933100.0 5774000.0 False True 2571204.632675176 5047904.607042661 5176561.8681189595 1.0 1.9632449875413591 2.0132827244998674 21.294013002832006 -10.991725246771304 0.520414106352085 3.92222047297452e-17 2.0101998991484056 0.9998166353300572 0.006314535536245521 2.813197546472127 0.2533215365947703 3.3851414831224598 0.009806053547216797 1.0192359963303444e-11 10.991725246771304 2.0101998991484056 ALKDPNAFLFDHLLTLKPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALKDPNAFLFDHLLTLKPVK 20 2 Q7L2H7;J3KNJ2;Q7L2H7-2;H0YCQ8 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 0 29243500.0 7181000.0 8225000.0 13837500.0 False True 6953043.085680676 11509285.392808372 10213043.633898204 1.0 1.6552875123859034 1.4688595350331253 22.729213098780143 -10.36848521067085 5.228452212600209 0.9997194900758376 1.5620735237095416 0.9237805195438408 0.07610890304900236 0.0002489832632472016 3.0073206375745772e-05 0.07372805361065075 0.024564042833894736 4.280699967004687e-11 10.36848521067085 0.562354033633704 ALKDPNAFLFDHLLTLKPVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALKDPNAFLFDHLLTLKPVK 20 2 Q7L2H7;J3KNJ2;Q7L2H7-2;H0YCQ8 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 0 28071540.0 1961240.0 10637400.0 15472900.0 False True 2686363.428518137 10167404.494822223 11818519.694378374 1.0 3.784820916963871 4.399449295994085 21.357223064354898 -9.696646004023062 0.41009606983907104 7.04525237347899e-21 4.4641807606799295 0.9985667224104513 0.05599619238733899 1.016878298084996 0.1758885718607313 1.543205652118528 0.1513986986248169 2.0107311035320773e-10 9.696646004023062 4.4641807606799295 ALKDPNAFLFDHLLTLKPVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALKDPNAFLFDHLLTLKPVK 20 2 Q7L2H7;J3KNJ2;Q7L2H7-2;H0YCQ8 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 0 22601100.0 7181000.0 8346500.0 7073600.0 False True 5971319.6722394265 8301535.747849471 8552657.055368902 1.0 1.3902346890660005 1.432289263482254 22.50961837421442 -12.013151077704459 0.3537140252073326 9.936298977153155e-08 1.4383297412083542 0.9996224972257652 0.0037815355545383162 5.4395639535517635 0.1854424366195722 4.026501295378492 0.0123835341515373 9.70172415366858e-13 12.013151077704459 1.4383296418453644 ALKDPNAFLFDHLLTLKPVK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALKDPNAFLFDHLLTLKPVK 20 2 Q7L2H7;J3KNJ2;Q7L2H7-2;H0YCQ8 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 1 159222200.0 8644200.0 113090000.0 37488000.0 True False 13113883.375669777 92908205.92379698 30078480.36842587 1.0 7.084721074778645 2.293636408588973 23.644591634073944 -6.5862171994056995 2.2423799169767524 5.127960839630022 2.306620385872513 0.0 2.639254835960129 0.680996824833409 6.449267338822613 0.9844791597835538 2.946055745250868 2.5928822852152493e-07 6.5862171994056995 -2.821340453757509 ALKPPPIK(ub)LYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALKPPPIKLYR 11 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 33064900.0 6881300.0 7256600.0 18927000.0 True False 6662856.898133181 10154198.222669076 13969450.90217102 1.0 1.5240006468567724 2.096615778448584 22.667709477702754 -6.9699874743118135 0.2584850684407796 0.8362350665627185 2.8013364988194116 0.9999822848292944 0.001884914707800654 0.07630676641275312 0.00904468358926041 0.012071463811227446 0.05415080157854131 1.0715502098675577e-07 6.9699874743118135 1.965101432256693 ALKPPPIK(ub)LYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALKPPPIKLYR 11 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 66869400.0 6743400.0 17005000.0 43121000.0 True False 10230230.808575867 13970324.889328567 34598115.44939433 1.0 1.3655923459339185 3.3819486673156183 23.28633535891662 -6.937642767422667 0.6811377757533311 0.97617967936009 3.88995723811745 0.9978385978217729 0.048693586524209666 0.08885862256646547 0.059630840970645804 0.04659230427461006 0.17542213376341603 1.1544024308173353e-07 6.937642767422667 2.91377755875736 up ALKPPPIK(ub)LYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALKPPPIKLYR 11 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 19704000.0 5428800.0 5989300.0 8285900.0 True False 7435974.067803677 5724672.922033466 6328941.073467147 1.0 0.7698618728137028 0.8511246832974084 22.826090308339467 -10.754884921678444 9.724967584538994 1.0007832283960285 0.8104932793951071 0.87880413409706 0.03317540345826173 0.0005655264193910102 1.4253926646287872e-05 0.032244811273934894 0.01070731542479664 1.7583894861077916e-11 10.754884921678444 -0.19028994900092144 ALKPPPIK(ub)LYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALKPPPIKLYR 11 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 25845000.0 6881300.0 8802700.0 10161000.0 True False 5722105.843278251 8755278.107900858 12285618.120844197 1.0 1.5300797202459424 2.147044891746645 22.44811475313703 -6.96912991199255 0.278182268964302 0.8610704429931327 2.834807900762264 0.9999747787356565 0.002353974849054866 0.07658603180062763 0.010036521670992603 0.011516753306966547 0.05676075832072705 1.0736681942639562e-07 6.96912991199255 1.9737374577691313 ALKPPPIK(ub)LYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALKPPPIKLYR 11 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 82113400.0 6743400.0 10115000.0 65255000.0 True False 8729464.232286546 9552091.358200384 53379259.572842225 1.0 1.0942356946571008 6.114837996061112 23.05746168100907 -6.910966059635277 0.8891353095006794 0.8492617223712251 6.777243578907494 0.9912809439161823 0.2230988902584794 0.10378251390234719 0.13532955689964837 0.18353104986386765 0.5100814211311626 1.22753515999201e-07 6.910966059635277 5.9279818565362685 up ALLDGLALNTHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALLDGLALNTHLR 13 0 Q6F5E8-2;Q6F5E8 Q6F5E8-2 RLTPR Leucine-rich repeat-containing protein 16C 0 7125900.0 1126100.0 3111200.0 2888600.0 False True 1476328.0051679132 2647021.0873626154 2589715.3814077675 1.0 1.7929762749854163 1.75415989694866 20.493581859053815 -10.102592912521846 4.779950495861623 0.9999609982419893 1.773568085974031 0.9981151582064082 0.0158467200089597 11033518.44956283 0.45698995645979673 4822.685450759949 0.005424753752021956 7.895999051242124e-11 10.102592912521846 0.7736070877320418 ALLDGLALNTHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALLDGLALNTHLR 13 0 Q6F5E8-2;Q6F5E8 Q6F5E8-2 RLTPR Leucine-rich repeat-containing protein 16C 0 6958400.0 2553500.0 1788500.0 2616400.0 False True 2472440.540215232 2502657.376904287 1931086.3496824766 1.0 1.0122214614254887 0.7810446068459834 21.237504395316407 -6.894421110598367 0.9958412043691768 1.011137178941456 0.7593481862801744 0.9835811384992985 0.013609903540286867 0.1156300329190478 0.20147067402875826 0.010347920607980437 0.026244427485481697 1.2752017187377193e-07 6.894421110598367 -0.25178899266128163 ALLDGLALNTHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALLDGLALNTHLR 13 0 Q6F5E8-2;Q6F5E8 Q6F5E8-2 RLTPR Leucine-rich repeat-containing protein 16C 0 10594200.0 1126100.0 6598500.0 2869600.0 False True 1542449.601708244 6306956.451678466 2191859.581267129 1.0 4.08892222131186 1.4210250881712254 20.556791920576707 -6.6105481893245575 2.1516495701616996 3.0628637799517895 1.4305578576747175 0.052252108556228194 1.3315255031768223 0.6109759712519871 5.3608560772423 0.5108890459903701 1.47816290810035 2.451612407753978e-07 6.6105481893245575 -1.632305922277072 ALLDGLALNTHLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALLDGLALNTHLR 13 0 Q6F5E8-2;Q6F5E8 Q6F5E8-2 RLTPR Leucine-rich repeat-containing protein 16C 0 4318410.0 2553500.0 953130.0 811780.0 False True 2123348.3892303794 947995.2995085089 981519.4447533619 1.0 0.446462438437677 0.46225077793716157 21.017909670750683 -10.07618321526979 6.022416836069225 1.0000014903870975 0.45435660821854884 0.9993724561168982 0.006445562609997495 1.2898531337267945e-07 1.9780956244375357e-08 0.006240906269984301 0.0020802963871112278 8.391059192752301e-11 10.07618321526979 -0.5456448821685487 ALLDPFLRLKVDGFLPF ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALLDPFLRLKVDGFLPF 17 2 H7C350 H7C350 LOC388849 0 23680600.0 18108000.0 4229400.0 1343200.0 False True 23739763.358121462 3598390.0060720746 1204218.548884204 1.0 0.15157649011867896 0.05072580255827345 24.5008022182408 -13.999999999999998 0.3004814663122944 8.7605062919765 0.026034978181172338 0.9996509051261597 0.00795412905174467 16.619848396225496 0.1741017275605406 80.21132601109127 0.0363714454605684 1.0000000000000041e-14 13.999999999999998 -8.734471313795327 ALLDPFLRLKVDGFLPF ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALLDPFLRLKVDGFLPF 17 2 H7C350 H7C350 LOC388849 0 13454000.0 8815800.0 2362900.0 2275300.0 False True 8535947.254524937 3306418.2923607174 1679330.6724631316 1.0 0.38735224032786436 0.19673629913457025 23.025119830787542 -13.999999999994259 0.16347429015175696 4.0404129845745445 0.01635350480181304 0.9995276644566853 0.007447692864648127 12.034665697003875 0.12787993236670145 11.600017064392274 0.16514988519037527 1.0000000000132196e-14 13.999999999994259 -4.024059479772731 ALLDPFLRLKVDGFLPF ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALLDPFLRLKVDGFLPF 17 2 H7C350 H7C350 LOC388849 0 166905700.0 18108000.0 6627700.0 142170000.0 False True 24803016.950300053 6334866.299126984 108592374.08305956 1.0 0.2554070866387223 4.378192148989596 24.56401227976369 -6.860155470963363 1.184831888646074 0.5958019210489334 4.578542628776242 0.9538370298341186 0.38543803427632367 0.14664788350305138 0.3910819179786483 0.25369572632085596 0.5923519470031097 1.3798901960125185e-07 6.860155470963363 3.982740707727309 up ALLDSLQLGPDSLTVHLIHEVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALLDSLQLGPDSLTVHLIHEVTK 23 0 Q14697;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 334849000.0 82619000.0 127470000.0 124760000.0 False True 125339063.2579605 104721982.57234411 100101131.31574938 1.0 0.8355095358963682 0.7986427272855159 26.901260875160077 -13.999999999999998 0.21014594677322376 1.9518779211974013 0.7769588951960004 0.9994900900082923 0.001976630583193665 12.750162824551378 0.14529846725068576 5.011427569183925 0.021815847719402513 1.0000000000000041e-14 13.999999999999998 -1.174919026001401 ALLDSLQLGPDSLTVHLIHEVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALLDSLQLGPDSLTVHLIHEVTK 23 0 Q14697;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 90275000.0 59548000.0 13076000.0 17651000.0 False True 49516800.42368937 13005556.992617207 21341742.490997013 1.0 0.26264938124708087 0.43100003046212354 25.561414760629482 -10.480574433758957 9.192116311508894 1.0000109751263448 0.3468247058749921 0.9525413691735833 0.06872886474052266 1.5458711322365945e-05 8.736183512838352e-07 0.06654755109584799 0.02218214571198221 3.306934296339914e-11 10.480574433758957 -0.6531862692513528 ALLDSLQLGPDSLTVHLIHEVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALLDSLQLGPDSLTVHLIHEVTK 23 0 Q14697;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 201063000.0 82619000.0 56075000.0 62369000.0 False True 106951924.16396526 52954376.95611347 51018481.95998155 1.0 0.49512318146731493 0.47702257213966925 26.672387197252526 ALLELQLEPEELYQTFQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALLELQLEPEELYQTFQR 18 0 P13639 P13639 EEF2 Elongation factor 2 0 563740000.0 149150000.0 229970000.0 184620000.0 False True 226271454.32557645 188930056.7361888 148129776.0781795 1.0 0.8349707977937949 0.6546551641686061 27.753479349445822 -6.969989357937315 0.2584424897564085 1.0515961764104922 0.4326909508503892 0.999982297286581 0.0005933602886258099 0.07630614950875342 0.009042607696079046 0.0038023375242723276 0.017053099830623364 1.0715455623414925e-07 6.969989357937315 -0.618905225560103 ALLELQLEPEELYQTFQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALLELQLEPEELYQTFQR 18 0 P13639 P13639 EEF2 Elongation factor 2 0 334844000.0 149150000.0 43234000.0 142460000.0 False True 193077615.1860397 40827989.89425958 116533741.76303884 1.0 0.21145895061382347 0.6035590487833243 27.52460567153827 -10.763467100139271 6.610577116539937 1.0161831396875536 0.4075089997187191 0.7527473798325189 0.1600741947684116 0.03697683942560507 0.0013230656543165148 0.1501106255129833 0.051663724207968414 1.7239826859212658e-11 10.763467100139271 -0.6086741399688345 ALLELVPWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALLELVPWR 9 0 H3BQK9;Q9UPN3-4;Q9UPN3-2;Q9UPN3;A0A590UJG2;H3BPE1;Q9UPN3-3;H0Y390;Q9UPN3-5 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 0 1506430.0 346630.0 488050.0 671750.0 False True 454435.2867696951 415234.8424039997 602243.7538810034 1.0 0.9137381151795064 1.3252574600048974 18.79371533848517 -6.851981471075174 1.2255324822374396 0.9538786604186043 1.342344132919321 0.9431337425189803 0.0422549975804763 0.1552913653022319 0.4478366584837074 0.026965684574827353 0.06248276389778742 1.4061075136202912e-07 6.851981471075174 0.38846547250071684 ALLELVPWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALLELVPWR 9 0 H3BQK9;Q9UPN3-4;Q9UPN3-2;Q9UPN3;A0A590UJG2;H3BPE1;Q9UPN3-3;H0Y390;Q9UPN3-5 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 0 1436530.0 346630.0 0.0 1089900.0 False True 474788.47832353134 0.0 832488.0671950959 1.0 0.0 1.7533872560147095 18.856925400008063 -6.752008924425926 1.642435456823352 0.4134165902150466 1.7574103283987035 0.6575750331986655 0.4202542529401829 0.2965462937978495 1.5745236541077592 0.2020785813497562 0.489556970464879 1.770072584279462e-07 6.752008924425926 1.3439937381836569 ALLEVVQSGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALLEVVQSGGK 11 0 O14818;O14818-2;Q8TAA3-5;Q8TAA3;A0A087WYS6;Q8TAA3-2 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 0 31792800.0 5481800.0 12095000.0 14216000.0 False True 7186692.88582671 10290473.145940743 12745064.689501071 1.0 1.4318787945196847 1.7734255368886496 22.776896604964357 -6.973768371921762 0.14170037062527066 0.553539011692328 2.6606864604301834 0.9999988660866058 0.00033694127083979953 0.07509779535883586 0.004297790166677549 0.018966571830942667 0.04414190636308998 1.0622619565038011e-07 6.973768371921762 2.107147448737855 ALLEVVQSGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALLEVVQSGGK 11 0 O14818;O14818-2;Q8TAA3-5;Q8TAA3;A0A087WYS6;Q8TAA3-2 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 0 17892900.0 6605600.0 3635800.0 7651500.0 False True 6395908.84372264 5087593.900446528 5647342.609920301 1.0 0.795445029745823 0.8829617100410944 22.608717946596695 -10.118732059331691 4.498154116776572 1.0000162052815817 0.8392033698881116 0.8182155296616237 0.03572853514438985 8222670.5491308635 18497143.49808682 831.9279902240299 0.012230828525465079 7.60795509675273e-11 10.118732059331691 -0.16081283539347013 ALLEVVQSGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALLEVVQSGGK 11 0 O14818;O14818-2;Q8TAA3-5;Q8TAA3;A0A087WYS6;Q8TAA3-2 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 0 50693800.0 2847000.0 45119000.0 2727800.0 False True 4319107.143579724 37067161.93364396 2188649.13436279 1.0 8.582135312096536 0.5067364762219844 22.04230167507815 -6.6604077884863795 1.9716755366082546 5.879011906427472 0.5405715778092259 0.23721014876423807 3.2280119573033854 0.4835020334588046 3.613796476406107 1.3225926899925344 3.578044316621436 2.1857083506011334e-07 6.6604077884863795 -5.338440328618246 ALLEVVQSGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALLEVVQSGGK 11 0 O14818;O14818-2;Q8TAA3-5;Q8TAA3;A0A087WYS6;Q8TAA3-2 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 0 25690800.0 5481800.0 10134000.0 10075000.0 False True 7508569.60007481 9686246.37134342 7695492.5011382615 1.0 1.2900255158115488 1.024894608563206 22.840106666487248 -10.548600495584969 3.161925244338338 0.9941235281866535 1.157460062143334 0.3198586086706722 0.10823924036856045 28005689.94309591 29099052.78271665 1366649.0617884956 0.03904957635404919 2.8274797575555097e-11 10.548600495584969 0.16333653395668046 ALLEVVQSGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALLEVVQSGGK 11 0 O14818;O14818-2;Q8TAA3-5;Q8TAA3;A0A087WYS6;Q8TAA3-2 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 0 11238500.0 6605600.0 2663100.0 1969800.0 False True 5492849.077697363 2648753.3517160383 2381676.072673843 1.0 0.48221848338611417 0.433595760412237 22.38912322203097 -13.999999999999998 0.334617439363352 6.795869475162854 0.4254433240854124 0.9997243440829295 0.004255562716688887 19.220868430474855 0.18523490826999983 78.58664773493142 0.015317704137609224 1.0000000000000041e-14 13.999999999999998 -6.370426151077441 ALLEVVQSGGK(ub)NIELAVMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALLEVVQSGGKNIELAVMR 19 1 O14818;O14818-2 O14818 PSMA7 Proteasome subunit alpha type-7 1 88739600.0 7698600.0 24010000.0 57031000.0 True False 11679339.043049831 19725227.909013763 45758797.85242466 1.0 1.6888993320860823 3.917927006293641 23.477455295767168 -6.949739420265809 0.561696221193509 0.9711020065180889 4.742563932904231 0.9991806817122975 0.035645771719089815 0.08359052998773611 0.03639657631211562 0.03813242524558656 0.18536169628537535 1.122691875250002e-07 6.949739420265809 3.771461926386142 ALLEVVQSGGK(ub)NIELAVMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALLEVVQSGGKNIELAVMR 19 1 O14818;O14818-2 O14818 PSMA7 Proteasome subunit alpha type-7 1 65088600.0 7698600.0 16192000.0 41198000.0 True False 9965989.462093493 15290900.96608807 33700386.72717728 1.0 1.5343083618790025 3.381539470351602 23.248581617859617 -6.948225942528652 0.5779914483462064 0.9777491308900718 4.02915110214106 0.9990546141291788 0.03137191283937261 0.08420602237261939 0.038971483775487696 0.03294143250465198 0.15422620159329248 1.1266111820774515e-07 6.948225942528652 3.051401971250988 ALLFIPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALLFIPR 7 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 112102000.0 32346000.0 32650000.0 47106000.0 False True 42405919.23910957 27778747.268703185 42231922.99265882 1.0 0.6550676831710741 0.9958968877559367 25.337762321945213 -10.879650689761801 10.096203103924664 1.0106357577592078 0.8254822854635061 0.25902766959107715 0.13914294011192835 0.03331100378384504 0.00039707490335340984 0.13472394586413772 0.04490819081631951 1.319317460785863e-11 10.879650689761801 -0.18515347229570167 ALLFIPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALLFIPR 7 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 85694000.0 41189000.0 14000000.0 30505000.0 False True 39881477.74071867 19590273.00903554 22514825.36961622 1.0 0.4912123150600818 0.5645434082455968 25.249215531563205 -10.632265604486774 6.573230179637197 1.0018065564588117 0.5278778616529283 0.9822278041373508 0.029937293430832738 0.0007950201784042799 4.4476702140026e-05 0.029075793354791303 0.009662219907344994 2.3320314094570532e-11 10.632265604486774 -0.4739286948058834 ALLFIPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALLFIPR 7 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 208413000.0 21318000.0 170670000.0 16425000.0 False True 32340964.554560035 140212605.04920352 13178591.550666748 1.0 4.335449080767559 0.40748913126676 24.94685937138826 -6.681780086571607 1.895902441309796 3.107116845651169 0.42241724684611903 0.3320189144496203 1.4131185905624768 0.4346581503258064 3.0222698521626175 0.597788200284416 1.5728439510831913 2.0807500485022973e-07 6.681780086571607 -2.68469959880505 ALLFIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALLFIPR 7 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 115807000.0 32346000.0 39914000.0 43547000.0 False True 44305190.31778246 38150467.50205265 33262095.47861718 1.0 0.8610834809288804 0.7507494097202198 25.400972383468105 -6.9737248569113754 0.1436075887307794 1.1403603392577675 0.46858619097735826 0.999998794931169 0.00011179899871336979 0.07511149960375883 0.004363235707350359 0.006007549370832675 0.014140335156573702 1.0623683973126165e-07 6.9737248569113754 -0.6717741482804092 ALLFIPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALLFIPR 7 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 69345000.0 41189000.0 16072000.0 12084000.0 False True 34250478.482087344 15985416.945957769 14610708.5298968 1.0 0.4667209818489976 0.4265840705711032 25.02962080699748 -13.999999999999998 0.3669544826004113 8.287493829304301 0.42222254573418944 0.9997856419788831 0.0038266277753531293 22.46815587177969 0.19635503945921345 128.62840795001264 0.011325532312950975 1.0000000000000041e-14 13.999999999999998 -7.865271283570112 ALLFIPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALLFIPR 7 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 82164000.0 21318000.0 29153000.0 31693000.0 False True 27596571.240603328 27530609.922453374 25925199.197641373 1.0 0.9976098002329759 0.9394355179710574 24.71798569348071 -6.915542662234469 0.8571185944047804 1.0015010923713152 0.9309526230132089 0.9928507625843923 0.0023678198808898447 0.10086627680219283 0.11972443907381336 0.001993345538947737 0.005738805486922213 1.214667293681736e-07 6.915542662234469 -0.07054846935810632 ALLFVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALLFVPR 7 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 25047400.0 4157400.0 10735000.0 10155000.0 False True 5450391.660318869 9133379.844702266 9104258.013638398 1.0 1.6757290877272346 1.6703860164621203 22.37792847372702 -10.37644974055892 4.753195330286421 0.9992685308710773 1.673057552095082 0.9999527369972449 0.002181299711201807 1.6925525080434182e-05 2.2203791819694742e-06 0.002114191973630802 0.000704011454350106 4.202911637471369e-11 10.37644974055892 0.6737890212240046 ALLFVPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALLFVPR 7 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 26274700.0 11795000.0 4221700.0 10258000.0 False True 11420574.181256587 5907446.825874666 7571122.066596402 1.0 0.5172635571659743 0.6629370771061673 23.445131849730817 -10.776455045451703 10.527610625513507 1.0018167005326513 0.5901003171360772 0.9134709251725928 0.05947096548143728 0.002542140367599916 5.398009461293969e-05 0.0577257845999436 0.019194171574373566 1.673188822008951e-11 10.776455045451703 -0.411716383396574 ALLFVPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALLFVPR 7 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 101858900.0 5897500.0 91675000.0 4286400.0 False True 8946938.665002258 75314879.98995571 3439191.1612041364 1.0 8.417949737887993 0.3843986518715302 23.09296269546271 -6.663972874149273 1.9582703093159441 5.758917124322991 0.4171730984414672 0.25291492341740285 3.15537531595096 0.47504266259452643 3.5058365444487776 1.2997752913328038 3.5007931098283844 2.1678395029350125e-07 6.663972874149273 -5.341744025881524 ALLFVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALLFVPR 7 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 27674400.0 4157400.0 11244000.0 12273000.0 False True 5694503.1295105675 10747202.901064293 9374370.170369219 1.0 1.8872942303550893 1.646213893849406 22.441138535249912 -10.562683777391682 7.131500737756444 0.9994166421095892 1.7667540621022468 0.9309743673827182 0.09842063524289803 0.0009134701553916706 5.601567960624539e-05 0.0953590927834446 0.03176512343490824 2.7372610813164124e-11 10.562683777391682 0.7673374199926576 ALLFVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALLFVPR 7 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 17211800.0 11795000.0 3093800.0 2323000.0 False True 9808065.107097065 3077133.085328781 2808728.559661553 1.0 0.3137349774628008 0.28636928170768067 23.225537125165093 ALLFVPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALLFVPR 7 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 24295300.0 5897500.0 7545800.0 10852000.0 False True 7634430.007104719 7125869.596708705 8877047.350923054 1.0 0.933385935829821 1.162764914035748 22.86408901755516 -6.829000496163705 1.3323625585654124 0.9643804471820013 1.1688126391042688 0.9038629479455286 0.029873302946697485 0.18204731254098425 0.6323844042721979 0.017606100040696553 0.040518651080350084 1.482516391430567e-07 6.829000496163705 0.20443219192226747 ALLITYGPYAINGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALLITYGPYAINGK 14 0 Q96S19 Q96S19 C16orf13 UPF0585 protein C16orf13 0 4337300.0 930900.0 1353200.0 2053200.0 False True 1275078.8866265912 1293411.1495660068 1568276.4469813455 1.0 1.014377355888871 1.2299446437627493 20.282155075878364 -6.920430855711167 0.821530719754068 0.9953171175359179 1.2650529965284028 0.9942996453797077 0.007940563038699014 0.0979189080687261 0.10430736010207599 0.0068572559161368726 0.020625929926773128 1.201072281242106e-07 6.920430855711167 0.26973587899248486 ALLLELK(ub)GLQEEPVEGFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALLLELKGLQEEPVEGFR 18 1 P49427 P49427 CDC34 Ubiquitin-conjugating enzyme E2 R1 1 6828200.0 1643400.0 1950400.0 3234400.0 True False 1591231.1665516798 2729204.891201633 2387213.6100798803 1.0 1.7151529888118202 1.5002305511983878 20.601712008143164 -10.375062275893997 5.266459160402421 0.9996892047643334 1.607691770005126 0.9142339487483491 0.0877417177380871 0.0003203442423592639 3.8013086324168364e-05 0.0849977786861752 0.028318517630592482 4.216360383638905e-11 10.375062275893997 0.6080025652407927 ALLLELK(ub)GLQEEPVEGFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALLLELKGLQEEPVEGFR 18 1 P49427 P49427 CDC34 Ubiquitin-conjugating enzyme E2 R1 1 32666000.0 3400600.0 8455400.0 20810000.0 True False 5158958.817160941 6946467.807658263 16696894.378652997 1.0 1.3464863849176871 3.2364853006990217 22.29864849914199 -6.937883324445221 0.6789674743903247 0.9778083053349225 3.7159171725476448 0.9978733398004224 0.04532501864532889 0.08874564001855569 0.059106913336842405 0.043442697009786625 0.16424305828199587 1.1537631808889407e-07 6.937883324445221 2.7381088672127225 up ALLLELK(ub)GLQEEPVEGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALLLELKGLQEEPVEGFR 18 1 P49427 P49427 CDC34 Ubiquitin-conjugating enzyme E2 R1 1 5702500.0 1643400.0 2182400.0 1876700.0 True False 1366559.9149642482 2170642.978027516 2269109.2931196075 1.0 1.5883994212462351 1.660453572706303 20.38211728357744 -11.487244581537798 0.35621012554508924 1.489657757114552e-12 1.6709907998112286 0.9995297558291747 0.006414966639288252 3.884572542333269 0.18253169773913552 3.0128957469381974 0.02102271841574962 3.2565325127283244e-12 11.487244581537798 1.6709907998097389 ALLLELK(ub)GLQEEPVEGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALLLELKGLQEEPVEGFR 18 1 P49427 P49427 CDC34 Ubiquitin-conjugating enzyme E2 R1 1 38331800.0 3400600.0 6180200.0 28751000.0 True False 4402143.735847441 5836266.437167588 23518613.0101722 1.0 1.3257782542723062 5.342536368964045 22.06977482123444 -6.923006357055987 0.8021144653663388 0.9206048680122162 6.03728887807325 0.9949761073977276 0.13997185483870847 0.09643496312299027 0.09668363931682056 0.12256153402577426 0.3783800411701022 1.19397062739746e-07 6.923006357055987 5.116684010061034 up ALLLGLACNHNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALLLGLACNHNLK 13 0 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1;Q5VZK9-3 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 0 12065900.0 6701200.0 2266200.0 3098500.0 False True 9178814.733120764 2166071.7906787517 2366698.115610611 1.0 0.23598600185955546 0.2578435434665258 23.12987643875308 -10.590032227555074 9.842519526716066 1.0000694589674142 0.24691477282434843 0.9993686044487751 0.008923303994788412 1.3601963305320654e-05 5.665552064953311e-07 0.00864072744805678 0.0028799839804134687 2.5702050492881762e-11 10.590032227555074 -0.7531546861430658 ALLLLLVGGVDQSPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALLLLLVGGVDQSPR 15 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 552160000.0 116410000.0 232910000.0 202840000.0 False True 176602480.71096444 191345390.76586425 162748585.09206963 1.0 1.0834807642313289 0.9215532218849818 27.39593036756812 -6.766617919324779 1.5877798329122101 1.0480899234861312 0.9207647295056636 0.7173106333375858 0.03515359740558074 0.27193753004328847 1.35251137566973 0.017458247474995775 0.041681752915825876 1.7115204028217067e-07 6.766617919324779 -0.1273251939804676 ALLLLLVGGVDQSPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALLLLLVGGVDQSPR 15 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 186319000.0 100790000.0 40905000.0 44624000.0 False True 83811350.75407471 40684636.645993255 53954672.08193604 1.0 0.4854311054522083 0.643763304092947 26.320642308704983 -10.900566686848753 11.279846528260641 1.0329077887479896 0.5645972047725777 0.9097703816961366 0.06463884942046635 0.03325574386353862 0.0002931531983063169 0.03890884130769144 0.020862098943622925 1.2572837809246438e-11 10.900566686848753 -0.4683105839754119 ALLLLLVGGVDQSPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALLLLLVGGVDQSPR 15 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 370400400.0 116410000.0 124360400.0 129630000.0 False True 150695039.78415602 117439634.41842271 106038670.11612198 1.0 0.7793198408297592 0.7036639710769751 27.16705668966057 -13.999999999999998 0.14939334315368036 2.066096225784234 0.6198441301490653 0.9995682757055139 0.002612099050026511 11.955485725953766 0.12169649027781126 3.700595293764761 0.07550646238747129 1.0000000000000041e-14 13.999999999999998 -1.4462520956351685 ALLLPDYYLVTVMLSGIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALLLPDYYLVTVMLSGIK 18 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 4219200000.0 1367600000.0 1638200000.0 1213400000.0 False True 2074749184.9524498 1345850410.6849792 973570958.1478882 1.0 0.6486810166963984 0.46924754337001995 30.950289794544002 -13.91628053381081 0.08747061833872283 2.798620378605124 1.734860589435144e-16 0.9998594503938312 0.0026133161844481946 11.773134164049901 0.08389581423156048 4.000915089255987 0.416977279714403 1.212605311424153e-14 13.91628053381081 -2.798620378605124 ALLLPDYYLVTVMLSGIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALLLPDYYLVTVMLSGIK 18 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 2365090000.0 1367600000.0 165600000.0 831890000.0 False True 1770385159.4262652 156384214.42590067 680494555.9122169 1.0 0.08833344178991008 0.38437655912838037 30.72141611663645 -10.374639610361827 5.815137237692912 1.0001763335791518 0.2363550017475008 0.8987013680922027 0.12085909655702815 0.0002763592052445794 2.9719784604459837e-05 0.11704767915109829 0.03900710568358632 4.220465841471543e-11 10.374639610361827 -0.763821331831651 ALLLSHQFK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALLLSHQFKR 10 1 H0Y4R5;Q5SNT2-2;Q5SNT2 H0Y4R5 TMEM201 Transmembrane protein 201 1 3787690.0 1550100.0 1457100.0 780490.0 True False 2032196.1111897526 1239706.3597313142 699732.3817887377 1.0 0.6100328373355296 0.3443232559770416 20.954608201251613 -8.188565774252517 0.19502549313038955 1.2824416881007785 2.900568640071456e-16 0.9998118806423094 0.0036932991627282507 0.08645906199512994 0.03982533602719392 0.10377372399811782 0.11455592327591024 6.4778997951983535e-09 8.188565774252517 -1.2824416881007783 down ALLLSHQFK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALLLSHQFKR 10 1 H0Y4R5;Q5SNT2-2;Q5SNT2 H0Y4R5 TMEM201 Transmembrane protein 201 1 5135200.0 1324500.0 1266300.0 2544400.0 True False 1282454.4724946443 1771940.1936672623 1877945.3096361777 1.0 1.3816788288947717 1.464336824357732 20.290476179973613 -12.221726071006072 0.24535542263638613 3.5948179255915454e-10 1.5019598503449696 0.9993982560839275 0.004961110153562674 5.80532420316465 0.14597295417718642 2.9476035338283135 0.03909624198733709 6.001695107039514e-13 12.221726071006072 1.5019598499854878 ALLLSHQFK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALLLSHQFKR 10 1 H0Y4R5;Q5SNT2-2;Q5SNT2 H0Y4R5 TMEM201 Transmembrane protein 201 1 4962530.0 1550100.0 878430.0 2534000.0 True False 2123213.859877406 839618.0580204462 1935521.3893681755 1.0 0.39544676769815623 0.9115998279513549 21.017818262774504 -10.274405003705192 8.093121118976969 1.0000004648853373 0.6535232978247653 0.37531227536914724 0.2107186044660596 1.7674438718019452e-06 1.585280820310189e-07 0.20402768506518776 0.06800913715275976 5.3161227009077536e-11 10.274405003705192 -0.3464771670605721 ALLLSHQFK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALLLSHQFKR 10 1 H0Y4R5;Q5SNT2-2;Q5SNT2 H0Y4R5 TMEM201 Transmembrane protein 201 1 5100300.0 1324500.0 1904600.0 1871200.0 True False 1101380.4352988594 1894339.5417665008 2262459.2685487308 1.0 1.7199683969803514 2.054203248975285 20.07088145540789 -10.134736001882313 0.17642308133969992 5.512380641876044e-15 2.42516989892221 0.999559742892173 0.0092295941596439 1.728336570249701 0.08428169974236342 1.0375740048801552 0.23932552748322783 7.33270136568562e-11 10.134736001882313 2.4251698989222046 ALLLSTYIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALLLSTYIK 9 0 O95782;O95782-2;O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O95782;O94973 AP2A1;AP2A2 AP-2 complex subunit alpha-1;AP-2 complex subunit alpha-2 0 7066300.0 1975500.0 3444400.0 1646400.0 False True 2589899.630769216 2930508.9461660394 1476046.3213839745 1.0 1.1315144847121588 0.5699241406299517 21.30446475797063 -6.845009336774716 1.2590088813449891 1.0699839203515358 0.5495537652192173 0.9327128224213945 0.062210102824505224 0.16303265990763127 0.49982499142829506 0.03871053422723914 0.0893344864434267 1.4288632394526522e-07 6.845009336774716 -0.5204301551323185 ALLLSTYIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALLLSTYIK 9 0 O95782;O95782-2;O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O95782;O94973 AP2A1;AP2A2 AP-2 complex subunit alpha-1;AP-2 complex subunit alpha-2 0 6500000.0 3423400.0 1308700.0 1767900.0 False True 3314726.0408744197 1831270.7347803437 1304833.9541368466 1.0 0.5524651848142651 0.3936476010526147 21.66045820714182 -13.999999999999998 0.1443210076789317 3.1473541623914416 0.20697061328309369 0.999586282990727 0.005221810411793757 11.940906593609746 0.1193217085143039 7.205527296904175 0.16741848948439716 1.0000000000000041e-14 13.999999999999998 -2.940383549108348 ALLLSTYIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALLLSTYIK 9 0 O95782;O95782-2;O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O95782;O94973 AP2A1;AP2A2 AP-2 complex subunit alpha-1;AP-2 complex subunit alpha-2 0 18264000.0 5153900.0 6551500.0 6558600.0 False True 7818843.1005604165 5382333.637896868 5262289.835263494 1.0 0.6883797984782543 0.6730266572156076 22.898523727169174 ALLLSTYIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALLLSTYIK 9 0 O95782;O95782-2;O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O95782;O94973 AP2A1;AP2A2 AP-2 complex subunit alpha-1;AP-2 complex subunit alpha-2 0 11727300.0 1975500.0 4444300.0 5307500.0 False True 2705895.735880151 4247936.130665248 4053977.811393677 1.0 1.569881675164958 1.4982017812578552 21.367674819493523 -10.566037804483209 6.201427260760457 0.9989125987776544 1.5340417282113799 0.9866685651486582 0.029263194148205808 0.0004407412290785659 3.084200701673382e-05 0.028384787951836726 0.009444655299402959 2.7162028184177735e-11 10.566037804483209 0.5351291294337255 ALLLSTYIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALLLSTYIK 9 0 O95782;O95782-2;O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O95782;O94973 AP2A1;AP2A2 AP-2 complex subunit alpha-1;AP-2 complex subunit alpha-2 0 6459300.0 3423400.0 1486600.0 1549300.0 False True 2846708.782334555 1478591.3907330027 1873251.4668461685 1.0 0.519403811133932 0.6580411310320037 21.440863482576095 -10.58791302184614 9.696076931601276 1.000041543964531 0.588722471082977 0.9214704638233557 0.05659844884287948 5.0833995148979835e-05 2.160419873467549e-06 0.05480670131621588 0.01826707081580372 2.582777403553227e-11 10.58791302184614 -0.4113190728815539 ALLLSTYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALLLSTYIK 9 0 O95782;O95782-2;O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O95782;O94973 AP2A1;AP2A2 AP-2 complex subunit alpha-1;AP-2 complex subunit alpha-2 0 15608200.0 5153900.0 6519300.0 3935000.0 False True 6671825.148557344 6156495.224074727 3218870.376509607 1.0 0.9227602772842379 0.4824572444326762 22.669650049261623 -6.9369280761900365 0.6875457471005555 1.0053020200494391 0.37373426298734236 0.9977332553197354 0.010853152104912413 0.08919638120721785 0.06120311698958633 0.010333328577583324 0.03843684392780925 1.1563037225964768e-07 6.9369280761900365 -0.6315677570620968 down ALLNNSHYYHMAHGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALLNNSHYYHMAHGK 15 0 P09622;E9PEX6;P09622-3;F8WDM5;A0A1W2PR83;F2Z2E3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 17956300.0 1681200.0 7498300.0 8776800.0 False True 2204069.4807639616 6379582.868144482 7868660.929010478 1.0 2.894456333533201 3.5700602896978952 21.071738273257573 -9.52341506639735 0.302486401606897 3.3255456970730994e-16 3.828540418678701 0.998710406814828 0.03906541627044351 0.9006349155956451 0.12249838519577412 1.1336249803431182 0.2346586782575381 2.996297511591032e-10 9.52341506639735 3.8285404186787004 ALLNNSHYYHMAHGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALLNNSHYYHMAHGK 15 0 P09622;E9PEX6;P09622-3;F8WDM5;A0A1W2PR83;F2Z2E3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 32582100.0 5269700.0 2861600.0 24450800.0 False True 5102416.257987942 4004251.8030468607 18046401.971723095 1.0 0.7847756044556574 3.5368345229519575 22.28274916893848 -6.888002731885932 1.0341578423296796 0.8449702743717052 3.76445014658062 0.9795876236402099 0.17854654360625816 0.12077726461646146 0.23144973776633532 0.13188532712316092 0.3265049809980294 1.2941877004663005e-07 6.888002731885932 2.919479872208915 up ALLNNSHYYHMAHGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALLNNSHYYHMAHGK 15 0 P09622;E9PEX6;P09622-3;F8WDM5;A0A1W2PR83;F2Z2E3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 18834200.0 1938400.0 14834100.0 2061700.0 False True 2940694.516022109 12186838.955647692 1654204.09132479 1.0 4.144204333108658 0.5625215683954957 21.48772549189987 -6.674829126364203 1.9201748700338541 2.998521407224593 0.5766205905211195 0.30066600703441715 1.3341183656330982 0.450109749099761 3.2039317388810886 0.5584303111546531 1.4826972523141408 2.1143207580053096e-07 6.674829126364203 -2.4219008167034737 ALLNNSHYYHMAHGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALLNNSHYYHMAHGK 15 0 P09622;E9PEX6;P09622-3;F8WDM5;A0A1W2PR83;F2Z2E3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 23941000.0 1681200.0 8940700.0 13319100.0 False True 2302785.0727216955 8545670.311058829 10173402.89547499 1.0 3.711015158248605 4.417869047349216 21.134948334780464 -9.58898327821824 0.383920666965725 1.7216523679372442e-18 4.531151412070183 0.9984367490220272 0.058244666813254374 0.926651079018695 0.16040872583148194 1.406459519024365 0.18677918615597436 2.57642035584417e-10 9.58898327821824 4.531151412070183 ALLNNSHYYHMAHGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALLNNSHYYHMAHGK 15 0 P09622;E9PEX6;P09622-3;F8WDM5;A0A1W2PR83;F2Z2E3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 14929100.0 5269700.0 5309300.0 4350100.0 False True 4381989.037292865 5280697.747086463 5259685.797410136 1.0 1.2050915011756413 1.2002964299197563 22.063154444372756 -10.102446943586623 4.615047130410929 0.9999854408509943 1.202693965551623 0.9995804426916906 0.0019575796594730227 2.9425334282295564e-07 5.722381310675524e-08 0.0018955548986191253 0.0006318061159892077 7.898653389108834e-11 10.102446943586623 0.2027085247006286 ALLNNSHYYHMAHGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALLNNSHYYHMAHGK 15 0 P09622;E9PEX6;P09622-3;F8WDM5;A0A1W2PR83;F2Z2E3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 30624000.0 1938400.0 8521700.0 20163900.0 False True 2509297.011576396 8047459.903823668 16494277.099085638 1.0 3.207057541095175 6.5732661470487175 21.25885181399232 -6.964978827771813 0.35841540531946486 0.7046321840614782 9.190764140248024 0.9999127085382239 0.021410595260524114 0.0779681412431185 0.014885274732794499 0.04531094041107367 0.2877916019141905 1.0839797576752728e-07 6.964978827771813 8.486131956186547 ALLQQQPEDDSK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALLQQQPEDDSKR 13 1 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 1 16247400.0 4833300.0 7321900.0 4092200.0 True False 6336503.105743783 6229501.060542654 3668778.3991542147 1.0 0.9831133918163576 0.5789910204302774 22.595255456406182 -6.915681802450352 0.856132140031174 1.0103782079775412 0.519881193450678 0.9928950891393781 0.016403585954078686 0.10077983430983868 0.11926991136846685 0.013819189695435496 0.03983080944458169 1.2142781982507486e-07 6.915681802450352 -0.49049701452686323 ALLQQQPEDDSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALLQQQPEDDSKR 13 1 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 1 19967200.0 4955800.0 5279300.0 9732100.0 True False 4798480.841667766 7387352.021185796 7182971.053258226 1.0 1.539518915452883 1.4969260668678015 22.194146302430962 -10.076520436330362 4.598081027491902 0.9999718779261408 1.51822249117449 0.9949591078662692 0.01738845769629338 12075731.255502712 0.032368547659110944 3758.25471779963 0.005952531563859389 8.384546230460518e-11 10.076520436330362 0.5182506132483491 ALLQQQPEDDSK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALLQQQPEDDSKR 13 1 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 1 59188400.0 11767000.0 21438900.0 25982500.0 True False 17851399.282930307 17612960.792109765 20847047.48646572 1.0 0.9866431484142232 1.167810273920649 24.089533828629655 -6.8891500575893865 1.0273570878102438 0.990066454817161 1.1831376340200377 0.9803501341485625 0.011555613554882046 0.11983710930738015 0.22587744454284192 0.008579431862516503 0.021325070422705025 1.290773208121209e-07 6.8891500575893865 0.19307117920287664 ALLQQQPEDDSK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALLQQQPEDDSKR 13 1 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 1 14188500.0 4833300.0 4528400.0 4826800.0 True False 6620301.625021273 4328320.314583737 3686809.2510664165 1.0 0.6537950322723897 0.5568944528346274 22.658465517929073 -13.999999999999998 0.17863254644264273 2.7888633076206606 0.4788247805896824 0.9994998503414764 0.004253671504837143 12.187338834148274 0.13396953994476446 7.564622762619294 0.07319902594432286 1.0000000000000041e-14 13.999999999999998 -2.310038527030978 ALLQQQPEDDSK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALLQQQPEDDSKR 13 1 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 1 20265600.0 4955800.0 9036100.0 6273700.0 True False 4120967.2791650323 8987420.735774577 7585501.663688641 1.0 2.180900775702242 1.8407090252911626 21.97455157786524 -10.029263775922711 4.545101184858791 0.9999624381876981 2.010804900161028 0.9216996727287506 0.13888270078503498 23999323.5267864 0.859825591199345 9829.49418347698 0.047543242504690233 9.348377125680056e-11 10.029263775922711 1.01084246197333 ALLQQQPEDDSK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALLQQQPEDDSKR 13 1 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 1 39532610.0 11767000.0 2040610.0 25725000.0 True False 15232613.46224691 1927048.2596596454 21043313.960790217 1.0 0.12650805224170594 1.381464448825198 23.860660150722104 -6.719564245702036 1.7613515856136024 0.4683283662057757 1.3794023072935329 0.5103206498947279 0.36758656366925535 0.35612800912967363 2.159075607277396 0.1657402136897419 0.4162097174478498 1.9073735430698458e-07 6.719564245702036 0.9110739410877571 ALLQSSASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALLQSSASR 9 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 13791500.0 1277900.0 6899200.0 5614400.0 False True 1675339.2752012028 5869866.2528709695 5033475.745127665 1.0 3.5036880826219616 3.0044515875885263 20.67602185658727 -10.115068064835102 5.063486458293614 0.9999255052031467 3.2540698351104123 0.9645147354336602 0.2038124456525301 0.00017140520107107268 2.995571161021318e-05 0.19734691511640154 0.06578018397759652 7.672412339988673e-11 10.115068064835102 2.2541443299072657 ALLQSSASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALLQSSASR 9 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 12496200.0 4027800.0 1886300.0 6582100.0 False True 3899939.693706248 2639509.426924552 4858050.551232616 1.0 0.6768077545363617 1.2456732495306466 21.89502038451352 -6.752565984444945 1.6401435530584585 0.8105509468232037 1.2470437448782195 0.6600334078838294 0.13582885520436533 0.29558419069841885 1.5651599093562643 0.0653967512495455 0.15835305929122126 1.7678036064429893e-07 6.752565984444945 0.43649279805501573 ALLQSSASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALLQSSASR 9 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 13830200.0 1277900.0 5979100.0 6573200.0 False True 1750374.163948995 5714923.591760352 5020745.53930342 1.0 3.2649725467079516 2.868384167632014 20.73923191811016 -10.085954692159616 4.7586544868968605 0.9999082095844554 3.066678357199177 0.973124060140664 0.16190652787593396 56272105.08865949 11.234168396595564 56969.26564999397 0.05542491093801034 8.204371320985856e-11 10.085954692159616 2.0667701476147213 ALLSALHWLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALLSALHWLLR 11 0 F5H5K2;F5GY88;A0A0B4J1W0;O75448-2;O75448;B4DDR8;J3KTL3;J3KSU0;F5H0M2;F5H2D6;E9PFL1 F5H5K2 MED24 Mediator of RNA polymerase II transcription subunit 24 0 48688100.0 16302300.0 19019100.0 13366700.0 False True 24731780.957772978 15624993.008093446 10724765.886167264 1.0 0.6317779150143512 0.43364308880459196 24.559862797446595 -10.98672543317141 0.11076210439582797 1.9961266465240333 2.77870577026871e-13 0.999854065625136 0.0028348136378240664 3.265702749170913 0.06616853861944819 1.112202524442737 0.2828303358163761 1.0310377504062272e-11 10.98672543317141 -1.9961266465237555 ALLSALHWLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALLSALHWLLR 11 0 F5H5K2;F5GY88;A0A0B4J1W0;O75448-2;O75448;B4DDR8;J3KTL3;J3KSU0;F5H0M2;F5H2D6;E9PFL1 F5H5K2 MED24 Mediator of RNA polymerase II transcription subunit 24 0 45346300.0 16302300.0 11917400.0 17126600.0 False True 21103648.71637526 11254186.213763451 14009734.533755887 1.0 0.5332815365255216 0.6638536644559057 24.330989119539044 -10.438092934263006 9.021760253779588 1.0000034215397466 0.5985676004907221 0.9264850281848285 0.05330584800980812 3.6685253961330675e-06 2.2847123134617355e-07 0.05161360506302255 0.017204388466454223 3.646759019262082e-11 10.438092934263006 -0.40143582104902453 ALLSGSNPPYLPFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALLSGSNPPYLPFR 14 0 A0A2R8Y3W8;C9JSP6;A0A2R8YEK7;A0A2R8Y5L8;A0A2R8Y6L0;A0A0U1RQX7;A0A2R8YDJ8;Q9UNH5-4;Q9UNH5-3;Q9UNH5;Q9UNH5-5;Q9UNH5-2 A0A2R8Y3W8 CDC14A Dual specificity protein phosphatase CDC14A 0 7346400.0 2325800.0 1493000.0 3527600.0 False True 3185711.1123817014 1427034.3233092276 2694453.5332025117 1.0 0.4479484400713121 0.8457934314037924 21.60318401521098 -10.259793861218192 5.816203037937778 1.0000174881661419 0.6468709357375593 0.5123036089749493 0.16241953758110583 3.683359036612645e-05 4.687880208181228e-06 0.15726981961706601 0.052420680345859526 5.498017764938787e-11 10.259793861218192 -0.3531465524285826 ALLSK(ub)NTAPDNGPILLQAQTTQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALLSKNTAPDNGPILLQAQTTQR 23 1 Q12788;J3KNP2;A0A087WYP7 Q12788 TBL3 Transducin beta-like protein 3 1 14254700.0 2736300.0 3181400.0 8337000.0 True False 2649437.6542748907 4451749.610781834 6153289.59536111 1.0 1.6802620750855932 2.322488919651581 21.337254748063522 -6.971821377105273 0.21017778517119481 0.6645186304414451 3.356164503911821 0.9999933190611374 0.0013956975407203344 0.07571598455005502 0.006873689938389779 0.019204612832090715 0.06652293052428035 1.0670348964843453e-07 6.971821377105273 2.691645873470376 ALLSK(ub)NTAPDNGPILLQAQTTQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALLSKNTAPDNGPILLQAQTTQR 23 1 Q12788;J3KNP2;A0A087WYP7 Q12788 TBL3 Transducin beta-like protein 3 1 11309300.0 2736300.0 4059900.0 4513100.0 True False 2275354.688643463 4038028.512872942 5456768.3437832855 1.0 1.774680902730098 2.3982055945029566 21.1176600234978 -6.973587771734948 0.14939316826322296 0.2689857313021083 3.9202916250174438 0.999998570440776 0.0006837940376833777 0.07515479744356372 0.0045637068871471394 0.03201545816594881 0.07797741813554734 1.0627037871287954e-07 6.973587771734948 3.6513058937153353 ALLTFYHVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALLTFYHVTK 10 0 F8WDV0;Q9UI26;Q9UI26-2;D6RJB1 F8WDV0 IPO11 Importin-11 0 29890700.0 10503000.0 4392700.0 14995000.0 False True 10169588.014051536 6146728.0176278865 11067359.659642542 1.0 0.6044225202766151 1.0882800408778148 23.277757898753652 -6.689306139328655 1.8682849245067688 0.7518536342120218 1.0866240503786946 0.36753158218645976 0.16732237531597463 0.41811524474588463 2.8288765512457306 0.07165132951787768 0.1867894379413857 2.0450025819610506e-07 6.689306139328655 0.3347704161666728 ALLTFYHVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALLTFYHVTK 10 0 F8WDV0;Q9UI26;Q9UI26-2;D6RJB1 F8WDV0 IPO11 Importin-11 0 24393700.0 6563700.0 7366000.0 10464000.0 False True 9957612.770746136 6051479.749179319 8395785.813465865 1.0 0.6077239483501098 0.8431524710552446 23.24736848264072 -10.308259207791872 5.694260164858924 1.0000316000711555 0.725438209702675 0.6445619654334658 0.09611329192081211 3.856206151283476e-05 4.684640110541874e-06 0.09307198913816264 0.031020431579871933 4.917459504914442e-11 10.308259207791872 -0.2745933903684805 ALLTFYHVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALLTFYHVTK 10 0 F8WDV0;Q9UI26;Q9UI26-2;D6RJB1 F8WDV0 IPO11 Importin-11 0 21762300.0 10503000.0 4633900.0 6625400.0 False True 8733709.86179232 4608936.260942872 8010740.507611569 1.0 0.5277180412307665 0.9172208184584248 23.05816317418793 -10.007082229310035 7.067873929339486 1.000000026637484 0.7224694298445958 0.4036696996747392 0.15901384293411913 6.68300622800862e-08 9.413475051450851e-09 0.1539645074347906 0.051321497125023666 9.838248107517158e-11 10.007082229310035 -0.27753059679288816 ALLTFYHVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALLTFYHVTK 10 0 F8WDV0;Q9UI26;Q9UI26-2;D6RJB1 F8WDV0 IPO11 Importin-11 0 32730500.0 6563700.0 16791000.0 9375800.0 False True 8496839.039869988 15856566.089524748 7669500.603831964 1.0 1.8661723512850459 0.9026298565671448 23.01849480473317 -6.669822680787683 1.9381635306290443 1.5529594132408644 0.9065399400111263 0.2782280277027831 0.36794611397025656 0.4615020043426478 3.3421428061762515 0.15284926971069918 0.4084452436569989 2.1388351817753872e-07 6.669822680787683 -0.6464194732297381 ALLVEVQLLESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALLVEVQLLESK 12 0 O00231;O00231-2 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 127503000.0 27745000.0 55127000.0 44631000.0 False True 42091193.43119757 45289156.14078306 35809663.28753783 1.0 1.0759770025245992 0.8507637909120455 25.32701507987438 -6.815689249281008 1.3902960904171493 1.041138058792029 0.8462821401079063 0.8742141821253187 0.03317882917593537 0.19913826614924637 0.7574544785178754 0.018758256804416142 0.04329486769170324 1.5286594686760862e-07 6.815689249281008 -0.19485591868412266 ALLVEVQLLESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALLVEVQLLESK 12 0 O00231;O00231-2 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 82210000.0 27745000.0 28634000.0 25831000.0 False True 35916449.43571351 27040492.72869109 21130023.04844205 1.0 0.7528721004867309 0.5883104644367052 25.098141401966828 -8.298088782961257 0.09392649433271301 1.557351050659609 8.528435905412177e-09 0.9999875640309966 0.0005966308694381817 0.08897796135286684 0.019770738942702214 0.15742368490663347 0.15615307184321872 5.033976885161392e-09 8.298088782961257 -1.5573510421311731 ALLVQVVNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALLVQVVNK 9 0 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 0 10245700.0 2928800.0 3196500.0 4120400.0 False True 3839685.1625395427 2719594.6598594133 3694060.5336677125 1.0 0.7082858475981638 0.9620738100371972 21.87255659041014 -10.1840631858955 7.084933577776663 1.0000002729934099 0.8351798292054923 0.3599442405848403 0.10360850180604245 4.4681335335921153e-07 5.1482143943035966e-08 0.10031866643300288 0.03343950016835862 6.545409373886428e-11 10.1840631858955 -0.1648204437879176 ALLVQVVNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALLVQVVNK 9 0 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 0 10693900.0 2928800.0 3961800.0 3803300.0 False True 4011656.507843975 3786754.576079372 2905038.871422247 1.0 0.9439378891675164 0.7241494544066863 21.935766651933033 -6.945336703243069 0.6078932187108171 1.0024388658071186 0.6542439696123497 0.9987826020942214 0.004153590373396337 0.08541418762071608 0.04414168190887863 0.004230491465945684 0.018519494764323515 1.1341311965796522e-07 6.945336703243069 -0.34819489619476895 ALLVQVVNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALLVQVVNK 9 0 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 0 4825800.0 1892600.0 1069100.0 1864100.0 False True 1573780.7563960918 1063340.5461002656 2253874.6913754223 1.0 0.675659898482481 1.432140202639613 20.58580314213203 -6.790183855453966 1.495627760571322 0.8187798851219881 1.4402271455749025 0.8019662746769333 0.13789752977485575 0.2350443788861018 1.0386806931758943 0.07257321468506911 0.16988677493902674 1.6211236609957428e-07 6.790183855453966 0.6214472604529144 ALLVTASQCQQPAENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALLVTASQCQQPAENK 16 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 48801000.0 13915000.0 14723000.0 20163000.0 False True 18242699.75305167 12526385.78980451 18076726.177153215 1.0 0.6866519736317579 0.990901918129158 24.120815915211928 -10.73388142105936 9.454562814129801 1.0004913515417648 0.8387769459795928 0.2724080300215478 0.12420951971478879 0.0012902170437438965 3.631583743873664e-05 0.12061812671088372 0.040088450107983224 1.845519247464983e-11 10.73388142105936 -0.16171440556217198 ALLVTASQCQQPAENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALLVTASQCQQPAENK 16 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 18512100.0 7442900.0 2158600.0 8910600.0 False True 7206629.213537483 3020540.2369502885 6576646.547729957 1.0 0.41913357097327486 0.9125828945626732 22.780893188840814 -10.218685999496149 7.904220863448956 1.000000222973033 0.6658582327679795 0.37941604546638186 0.2014498427859214 7.915738020126598e-07 7.813994949205691e-08 0.19505310088826378 0.06501765718383136 6.043854499082974e-11 10.218685999496149 -0.3341419902050534 ALLVTASQCQQPAENK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALLVTASQCQQPAENK 16 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 84012700.0 9544700.0 61476000.0 12992000.0 False True 14480007.711038055 50505127.4858197 10424125.505404113 1.0 3.4879213114865837 0.7198977868953648 23.787559034911204 -6.669818963380049 1.9376888235666676 2.5882494111203536 0.731016824815022 0.2783672215593965 1.0568539741554477 0.4615442779844928 3.3406623609515567 0.43908644441759237 1.1735452086515858 2.13885348952875e-07 6.669818963380049 -1.8572325863053316 ALLVTASQCQQPAENK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALLVTASQCQQPAENK 16 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 44085000.0 13915000.0 12451000.0 17719000.0 False True 19059751.538735628 11900873.650049035 13534137.134259924 1.0 0.6243981526129855 0.710089903677608 24.18402597673482 -10.27860989829392 6.202619610494653 1.0000111587993046 0.6672440281452995 0.9526187287121021 0.03498351087898807 5.398488877535227e-06 6.278545549048503e-07 0.03387377408554751 0.01129087958551542 5.2648996965766675e-11 10.27860989829392 -0.3327671306540051 ALLVTASQCQQPAENK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALLVTASQCQQPAENK 16 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 14573400.0 7442900.0 3249300.0 3881200.0 False True 6189101.12637666 3231795.3759644483 4692740.975358774 1.0 0.5221752416019202 0.758226579197307 22.56129846427509 -10.1081369774949 5.256676571856257 1.0000073760619204 0.640200910399266 0.7559634508984213 0.0963675550362416 8.330600638705722e-06 1.4135448460538736e-06 0.09330939638057204 0.03110249464733215 7.795841890674286e-11 10.1081369774949 -0.3598064656626544 ALLVTASQCQQPAENK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALLVTASQCQQPAENK 16 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 28706100.0 9544700.0 11059000.0 8102400.0 False True 12355802.304164866 10443556.928357694 6627846.337644581 1.0 0.8452350297671406 0.5364156996434365 23.558685357003654 -6.960089860266797 0.4341669580647972 1.0117381881960583 0.35798801202112207 0.9997735130910231 0.0029001698742028913 0.07966905032079691 0.021012950024167056 0.00404408108273442 0.025617727370380247 1.0962513463106326e-07 6.960089860266797 -0.6537501761749362 ALMCLSLYLIHKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALMCLSLYLIHKR 13 1 Q96I27;Q96I27-2 Q96I27 ZNF625 Zinc finger protein 625 0 26458900.0 13212000.0 5911600.0 7335300.0 False True 12792592.29188315 8272132.708586749 5413964.875716961 1.0 0.6466345928835225 0.423210929590252 23.608805305889515 -8.672284904721131 0.1441932154812953 1.4613348579473333 3.9702976256184493e-11 0.9998982455008789 0.0023952996759278844 0.24204587029590804 0.03932949964923955 0.2039026371911687 0.15862775738691418 2.1267434076475084e-09 8.672284904721131 -1.4613348579076304 ALMDEVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALMDEVVK 8 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 37609600.0 7804100.0 2788500.0 27017000.0 False True 7556363.117248356 3901962.5918353964 19940437.207373276 1.0 0.5163810329507157 2.638893459454946 22.84926060070453 -6.84681504469655 1.2504969560491075 0.7424815839201026 2.718606922058136 0.9355217764281926 0.23063813106640155 0.16099681497253193 0.4860946517172818 0.14443895576769536 0.33360405204251004 1.4229346508587663e-07 6.84681504469655 1.9761253381380333 up ALMDEVVK(ub)ATSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALMDEVVKATSR 12 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 5528200.0 1556600.0 2470000.0 1501600.0 True False 1294381.8690722568 2456693.619743386 1815577.6173860496 1.0 1.897966649906964 1.402659957441584 20.303831873936208 -10.329363218359592 5.099198026962493 0.9997525924863779 1.6503133036743751 0.6968275703757629 0.20220811045465362 0.0005689532830067775 7.482782960297163e-05 0.19585996602088385 0.06526238702152812 4.684214581218467e-11 10.329363218359592 0.6505607111879972 ALMDEVVK(ub)ATSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALMDEVVKATSR 12 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 5223000.0 1168300.0 4054700.0 0.0 True False 1512387.380635935 3829052.380632241 0.0 1.0 2.5317933947730933 0.0 20.528396285961172 -6.743928448908024 1.678995283391947 1.9082852780419077 5.059448027908243e-15 0.6178802292564884 0.6436097340805257 0.31173516844985766 1.7281430903908164 0.30344167603839295 0.7395135133798681 1.803314816971182e-07 6.743928448908024 -1.9082852780419026 ALMDLLQLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALMDLLQLTR 10 0 H3BRB3;Q14807-2;Q14807;H3BTH5 H3BRB3 KIF22 Kinesin-like protein;Kinesin-like protein KIF22 0 2164880.0 385770.0 673710.0 1105400.0 False True 505748.20580199396 573195.0941010115 991023.8117455327 1.0 1.133360608154928 1.9595201730355312 18.948059771108344 -6.935162129287961 0.7031307227889101 0.98951342563243 2.153809875099544 0.9974590763871651 0.021392745729050158 0.09004452695515015 0.06518953976202561 0.020127584983250693 0.07274880718873894 1.1610151068529553e-07 6.935162129287961 1.1642964494671137 ALMGLYHGQVLCK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ALMGLYHGQVLCK 13 0 H0YFD6;P40939;A0A2R8Y4F5;A0A2R8YG21 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 47035200.0 15525700.0 11892100.0 19617400.0 False True 20354343.0510927 10117845.03504274 17587579.631388444 1.0 0.49708531538676093 0.8640701194453081 24.27883332257349 -10.2557909913587 5.791191138705634 1.000015649792824 0.6805777174160336 0.5025172744068032 0.14982091888312885 3.0274191621858133e-05 3.890486504299483e-06 0.14507058215906288 0.04835449364565256 5.548926964684543e-11 10.2557909913587 -0.3194379323767905 ALMGLYHGQVLCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALMGLYHGQVLCK 13 0 H0YFD6;P40939;A0A2R8Y4F5;A0A2R8YG21 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 13959500.0 6742200.0 2176600.0 5040700.0 False True 6528172.551493697 3045727.7308190493 3720389.4522414226 1.0 0.4665513521271987 0.5698975360861392 22.638247760195817 -9.964224940779081 5.810937547671644 1.000000461339433 0.5182244441065814 0.9666400475441946 0.04219090292795956 2.521252519033274e-07 4.4940353587533036e-08 0.04085120505715191 0.013617055366676095 1.0858630602892036e-10 9.964224940779081 -0.4817760172328517 ALMGLYHGQVLCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALMGLYHGQVLCK 13 0 H0YFD6;P40939;A0A2R8Y4F5;A0A2R8YG21 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 17111200.0 3621700.0 8258500.0 5231000.0 False True 5494383.681736106 6784706.151044996 4197090.557171251 1.0 1.2348438958855485 0.763887416731163 22.38952622899356 -6.771108807001016 1.5700505811348995 1.1345088746160061 0.7611167237990404 0.7348390440485291 0.09900576038964053 0.2646408666084498 1.2875731673197421 0.04969838364635958 0.11819051644148165 1.6939133586679063e-07 6.771108807001016 -0.37339215081696575 ALMGLYHGQVLCK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ALMGLYHGQVLCK 13 0 H0YFD6;P40939;A0A2R8Y4F5;A0A2R8YG21 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 48739300.0 15525700.0 13064700.0 20148900.0 False True 21265970.8562665 12487458.354814515 15390144.79962131 1.0 0.5872037744815588 0.7236981985746612 24.34204338409638 -10.342491660465232 4.963041516773101 1.0001879359328663 0.6554509865280138 0.8946917273520782 0.05572361529419163 0.00011594003474077413 1.535986840458506e-05 0.05398333495605477 0.01798471950202515 4.5447326414332e-11 10.342491660465232 -0.34473694940485244 ALMGLYHGQVLCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALMGLYHGQVLCK 13 0 H0YFD6;P40939;A0A2R8Y4F5;A0A2R8YG21 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 4390230.0 1450700.0 2243700.0 695830.0 False True 1206321.3269067989 2231612.742760418 841324.8358455874 1.0 1.8499322634729758 0.6974301266834758 20.20218281734838 -6.709136251183761 1.798492463170718 1.5229828454865473 0.7002294776252004 0.46092727490386043 0.35820519520859667 0.376802110370992 2.375340388535914 0.15853741792902218 0.4031505124710208 1.9537264171354623e-07 6.709136251183761 -0.8227533678613469 ALMGLYHGQVLCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALMGLYHGQVLCK 13 0 H0YFD6;P40939;A0A2R8Y4F5;A0A2R8YG21 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 18803500.0 3621700.0 8561100.0 6620700.0 False True 4688362.044380019 8084667.259188279 5415800.53411871 1.0 1.7244118911165234 1.1551583437568942 22.16065255108601 -10.20751482163425 4.186990785991236 0.9997939062556607 1.4397851174634988 0.44314759729387654 0.23239678767294808 163490274.674711 128.50853104853445 333209.30741886003 0.07955560179433165 6.201334793313176e-11 10.20751482163425 0.43999121120783813 ALMLQGVDLLADAVAVTMGPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALMLQGVDLLADAVAVTMGPK 21 0 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25;C9JCQ4;C9JL19;C9J0S9 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 1250750000.0 207240000.0 761400000.0 282110000.0 False True 314398231.27343214 625522221.1546468 226350834.84679455 1.0 1.9895856876199476 0.719949453691224 28.228017860473326 -6.698715075395038 1.8353260542969796 1.6152691968243884 0.723803660473727 0.4114900277074295 0.4178165251355186 0.3982278699290713 2.6069394557840693 0.1816730973363479 0.4679796051487221 2.0011743357897907e-07 6.698715075395038 -0.8914655363506614 ALMLQGVDLLADAVAVTMGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALMLQGVDLLADAVAVTMGPK 21 0 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25;C9JCQ4;C9JL19;C9J0S9 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 408393000.0 207240000.0 90983000.0 110170000.0 False True 268276265.31112847 85919716.06951517 90120190.43966024 1.0 0.3202658124447623 0.3359230841205613 27.999144182565775 -9.91936779282437 6.535369713312469 1.0000000582072839 0.3280944483620761 0.999592900568266 0.00639205439505164 5.4296913696196675e-09 8.890305410514615e-10 0.0061890806083290196 0.0020630266849956717 1.2040158584353415e-10 9.91936779282437 -0.6719056098452079 ALMQVVDFLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALMQVVDFLSR 11 0 Q9GZT8-2;Q9GZT8;E7EXA3;Q6X734;Q9GZT8-3 Q9GZT8-2 NIF3L1 NIF3-like protein 1 0 7963180.0 636780.0 3331500.0 3994900.0 False True 872214.7743324526 3184303.3142027413 3051386.8975481093 1.0 3.6508247829668328 3.498435233321381 19.734323902686686 -10.238584226801484 4.131472437956304 0.9981612447891848 3.5746300083102702 0.9973793900668002 0.06221277372922278 3523951.0756159597 1747273.326196231 56063.444475108336 0.021297086915747523 5.7731889698856874e-11 10.238584226801484 2.5764687635210857 ALNATK(ub)LER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALNATKLER 9 1 A0A087WT20;Q9NV06;E5RHM4;B3KME9;Q9NV06-2 A0A087WT20 DCAF13 DDB1- and CUL4-associated factor 13 1 4820490.0 900040.0 795450.0 3125000.0 True False 1165119.522440785 751182.5082432531 2556282.0652077515 1.0 0.6447257073416951 2.194008439454047 20.152046529000124 -6.846394369746576 1.2524472526128385 0.8108515056456052 2.2517380465620707 0.9348796543563105 0.16910403324783588 0.16146953188266783 0.48923805571982154 0.10574592625641127 0.24419255889553323 1.4243136298514892e-07 6.846394369746576 1.4408865409164655 up ALNFGLGRPLPLHFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALNFGLGRPLPLHFLR 16 1 P14635;P14635-2;E9PC90;H0YA62 P14635 CCNB1 G2/mitotic-specific cyclin-B1 0 60568000.0 18694000.0 15688000.0 26186000.0 False True 28360164.714464143 12888353.829096533 21010325.6222685 1.0 0.45445271418057964 0.7408393369292702 24.757362575916275 -10.60022262218587 7.919181692909342 1.0002745987803858 0.597646025554925 0.7246530575969027 0.11691684914887217 0.000567209334221285 2.8633914981354784e-05 0.11327866711807896 0.03773475080371888 2.5105991520929315e-11 10.60022262218587 -0.40262857322546086 ALNFGLGRPLPLHFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALNFGLGRPLPLHFLR 16 1 P14635;P14635-2;E9PC90;H0YA62 P14635 CCNB1 G2/mitotic-specific cyclin-B1 0 75888000.0 18694000.0 28809000.0 28385000.0 False True 24199751.51383055 27205753.824853733 23219221.254695054 1.0 1.1242162469852306 0.9594818046550971 24.528488898008725 -6.704970266127282 1.8129475834107265 1.076753156146549 0.9599199891090112 0.4412988326616223 0.05238694548541079 0.38526364467778673 2.4650641392672616 0.02302224089790555 0.05885090348343563 1.972557782210818e-07 6.704970266127282 -0.11683316703753788 ALNLGILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALNLGILR 8 0 Q7Z7G8-2;Q7Z7G8-6;Q7Z7G8 Q7Z7G8-2 VPS13B Vacuolar protein sorting-associated protein 13B 0 6309100.0 2092600.0 1530600.0 2685900.0 False True 2743418.864767227 1302240.4462320716 2407988.8329720693 1.0 0.47467795128053253 0.8777328405432474 21.387543478782828 -9.82832373238234 6.355363344713589 1.0000000115835377 0.6762053959118046 0.4625093270434467 0.16454646950492233 2.7054089866076465e-08 4.856208491483915e-09 0.1593214411395261 0.05310714467243585 1.484828406852823e-10 9.82832373238234 -0.32379461567173307 ALNLGILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALNLGILR 8 0 Q7Z7G8-2;Q7Z7G8-6;Q7Z7G8 Q7Z7G8-2 VPS13B Vacuolar protein sorting-associated protein 13B 0 9357000.0 3472100.0 1188900.0 4696000.0 False True 3361880.086031455 1663633.9700315965 3465976.7230197615 1.0 0.4948522634534059 1.0309638161756054 21.680836835726616 -11.73876542317528 13.620139628847271 0.9088824142589612 0.7866172358320201 0.0 0.25190226575145014 0.0 0.0 0.0 0.07303463333397461 1.8248811148619807e-12 11.73876542317528 -0.12226517842694107 ALNLGILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALNLGILR 8 0 Q7Z7G8-2;Q7Z7G8-6;Q7Z7G8 Q7Z7G8-2 VPS13B Vacuolar protein sorting-associated protein 13B 0 10263100.0 2092600.0 2910800.0 5259700.0 False True 2866290.7703886605 2782191.231271601 4017467.1869217753 1.0 0.9706591040986201 1.4016258323913937 21.45075354030572 -6.890597664479245 1.018859571416588 0.9771742787500477 1.4391272736784486 0.9812773942472924 0.026902145847305617 0.11865880802988421 0.21903527801834793 0.020103003705267557 0.05022523915499553 1.2864779163481703e-07 6.890597664479245 0.4619529949284009 ALNQEQVIAVHIDNGFMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALNQEQVIAVHIDNGFMR 18 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 9003100.0 3636900.0 3653200.0 1713000.0 False True 4768011.119789698 3108156.80006207 1535755.1922562832 1.0 0.6518770032145313 0.3220955559189259 22.184956169731368 -7.408561884442822 0.2684477232330641 1.108124584286394 1.0257800334538357e-15 0.9998693961001426 0.003163174751886106 0.1182950623913683 0.022690342364631688 0.020005572265255803 0.05753106969169829 3.90335557993346e-08 7.408561884442822 -1.108124584286393 down ALNQEQVIAVHIDNGFMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALNQEQVIAVHIDNGFMR 18 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 28088100.0 11466000.0 5635100.0 10987000.0 False True 11102018.106171079 7885224.8166583 8109175.097065184 1.0 0.7102514823206136 0.730423515753202 23.404318615302603 -10.474605266709549 6.074106425116623 1.0001800241263301 0.7203374990369079 0.9961131209930106 0.008235198164034167 2.0089343866602263e-05 1.7376816877725653e-06 0.007978778350809911 0.002657898778501836 3.352700299883861e-11 10.474605266709549 -0.2798425250894222 ALNQEQVIAVHIDNGFMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 ALNQEQVIAVHIDNGFMR 18 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 189119400.0 59381100.0 65799300.0 63939000.0 False True 90085470.03990932 54056900.82272261 51301428.62454071 1.0 0.6000623718650135 0.5694750618697261 26.424791095535703 -13.999999999999998 0.3646039214441475 6.385460962495111 0.5660314753794662 0.9997815198519509 0.0028991512390374504 22.20265831677513 0.19552511761208918 93.23421639747217 0.008695888793109965 1.0000000000000041e-14 13.999999999999998 -5.819429487115645 ALNQEQVIAVHIDNGFMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALNQEQVIAVHIDNGFMR 18 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 16531400.0 3636900.0 4602800.0 8291700.0 False True 4981560.213526959 4399433.076575836 6333371.232921889 1.0 0.8831436112384207 1.2713629789567162 22.24816623125426 -6.825988978903119 1.345699567417057 0.9373660969411967 1.2809820388405684 0.8976196945140125 0.05203341487450341 0.18581265158634488 0.6594729839613022 0.03037090227891851 0.06991618896044333 1.4928322927233894e-07 6.825988978903119 0.3436159418993717 ALNQEQVIAVHIDNGFMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALNQEQVIAVHIDNGFMR 18 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 24856100.0 11466000.0 7485900.0 5904200.0 False True 9534487.0299258 7445571.970865189 7138740.922063616 1.0 0.7809095494593307 0.7487283688841696 23.18472389073688 -13.999999999999998 0.2701201633031087 2.6921112258449345 0.7380587047122293 0.9995835842235996 0.002278171608075568 14.888769728486272 0.16452532147819038 13.835863643286455 0.013357366930845068 1.0000000000000041e-14 13.999999999999998 -1.9540525211327051 ALNQEQVIAVHIDNGFMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALNQEQVIAVHIDNGFMR 18 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 84736000.0 21054000.0 39340000.0 24342000.0 False True 27254818.036385335 37150694.41736074 19912005.77001189 1.0 1.3630872298528778 0.7305866340193228 24.700007952551655 -6.751028917946577 1.6460119708552676 1.2132370485543238 0.7292293477363283 0.65337252947211 0.15258036600804553 0.29826651371338103 1.5902624378464374 0.07321649624488678 0.1775599817928529 1.774071348584384e-07 6.751028917946577 -0.4840077008179955 ALPAVQQNNLDEDLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALPAVQQNNLDEDLIR 16 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 24207800.0 5891300.0 3212500.0 15104000.0 False True 5704283.906234582 4495268.002966191 11147809.28971262 1.0 0.788051239534733 1.954287246735468 22.443614356842957 -6.859838238523186 1.1864430665939703 0.8850422212341972 2.0106168841794996 0.953450315701868 0.10944037993955782 0.14697499787964588 0.39320307975841706 0.0719454088781541 0.167923811759986 1.38089851149435e-07 6.859838238523186 1.1255746629453025 ALPFWNEEIVPQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALPFWNEEIVPQIK 14 0 P18669;P15259;Q8N0Y7 P18669 PGAM1;PGAM2;PGAM4 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2;Probable phosphoglycerate mutase 4 0 23842500.0 2023300.0 17304000.0 4515200.0 False True 2652565.893665074 14722310.650463704 4048010.4168567304 1.0 5.550214863888549 1.5260734621237093 21.338957159590716 -6.6165358291730865 2.1288632518420587 4.026416281024956 1.5409404640004274 0.07141264653448909 1.95846206690977 0.5948276210028062 5.117351926381765 0.7570695743450045 2.173182023514219 2.4180438417618193e-07 6.6165358291730865 -2.485475817024529 ALPFWNEEIVPQIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALPFWNEEIVPQIK 14 0 P18669;P15259;Q8N0Y7 P18669 PGAM1;PGAM2;PGAM4 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2;Probable phosphoglycerate mutase 4 0 32893400.0 12308000.0 7447400.0 13138000.0 False True 11917289.27705858 10421185.657677932 9696763.668448377 1.0 0.874459402251758 0.8136719217779806 23.506552779937536 -13.999999496696983 0.09559874403574582 1.6288479924598323 0.6748910028340899 0.9998155353735977 0.0010537147852031305 12.115485352518727 0.0911595648044243 1.5211795339344707 0.12412728386732907 1.0000011588986959e-14 13.999999496696983 -0.9539569896257424 ALPFWNEEIVPQIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALPFWNEEIVPQIK 14 0 P18669;P15259;Q8N0Y7 P18669 PGAM1;PGAM2;PGAM4 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2;Probable phosphoglycerate mutase 4 0 33019300.0 2023300.0 14553000.0 16443000.0 False True 2771368.6876265793 13910000.339664593 12559502.054215023 1.0 5.019180739743877 4.531877014519881 21.402167221113608 -10.479172565403887 4.918827754963168 0.989645782306574 4.775528877132148 0.9876600718558319 0.19894091276035586 0.02234067349738497 0.0023655281319005747 0.1905027345105381 0.06420790349987253 3.31762606639704e-11 10.479172565403887 3.7858830948255737 ALPFWNEEIVPQIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALPFWNEEIVPQIK 14 0 P18669;P15259;Q8N0Y7 P18669 PGAM1;PGAM2;PGAM4 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2;Probable phosphoglycerate mutase 4 0 16866300.0 12308000.0 1639200.0 2919100.0 False True 10234647.336850408 1630369.304244275 3529470.3136065635 1.0 0.15929902131302962 0.34485509831867994 23.286958055371812 -10.533700975046692 9.294559512072883 1.0000346587437072 0.2520770607036202 0.9558736105105183 0.07575295122273767 5.4407955166094374e-05 2.7296712670392557e-06 0.07335083723844553 0.024449159875977147 2.926166438941059e-11 10.533700975046692 -0.747957598040087 ALPLIVGAQLIHADK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALPLIVGAQLIHADK 15 0 Q5SSJ5;B0QZK9;B0QZK8;Q5SSJ5-5 Q5SSJ5 HP1BP3 Heterochromatin protein 1-binding protein 3 0 10443340.0 2522130.0 3255810.0 4665400.0 False True 3306536.85434166 2770055.83904798 4182669.1616768627 1.0 0.8377513879546656 1.264969769257159 21.65688955112836 -6.803766972465698 1.4402835342311946 0.9109045135594948 1.271445078076615 0.8430159648252884 0.06976648282886987 0.21541380388905254 0.8817411055282427 0.0380988699722682 0.08841657813448327 1.571205633289252e-07 6.803766972465698 0.36054056451712035 ALPLIVGAQLIHADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALPLIVGAQLIHADK 15 0 Q5SSJ5;B0QZK9;B0QZK8;Q5SSJ5-5 Q5SSJ5 HP1BP3 Heterochromatin protein 1-binding protein 3 0 8984600.0 4135800.0 1752100.0 3096700.0 False True 4004511.292822461 2451722.6670807926 2285581.370991335 1.0 0.6122401681012039 0.5707516358083262 21.93319475741586 -13.999999999999998 0.3156788163911272 4.875405249624941 0.5621118570849913 0.9996844022238112 0.0034342343851170346 17.68436632094005 0.17899637687388192 45.15747373942327 0.01405099180446371 1.0000000000000041e-14 13.999999999999998 -4.31329339253995 ALPLIVGAQLIHADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALPLIVGAQLIHADK 15 0 Q5SSJ5;B0QZK9;B0QZK8;Q5SSJ5-5 Q5SSJ5 HP1BP3 Heterochromatin protein 1-binding protein 3 0 7317830.0 2522130.0 2120000.0 2675700.0 False True 3454629.6190004516 2026331.3900974977 2043754.7677712787 1.0 0.5865553224440275 0.5915988088941964 21.72009961265125 -9.932729476516016 5.56466942054593 1.0000004728819314 0.5890770656684926 0.9998870317059476 0.0020589947242081325 1.2078512709981177e-08 2.3169269459810326e-09 0.0019936153552882726 0.0006645376893039794 1.1675366530834305e-10 9.932729476516016 -0.4109234072134388 ALPLIVGAQLIHADK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALPLIVGAQLIHADK 15 0 Q5SSJ5;B0QZK9;B0QZK8;Q5SSJ5-5 Q5SSJ5 HP1BP3 Heterochromatin protein 1-binding protein 3 0 5915930.0 4135800.0 631830.0 1148300.0 False True 3439100.9470056794 628426.206381564 1388404.2208606836 1.0 0.18272979364816716 0.4037113891842939 21.713600032850135 -10.252062695229593 5.0741722439906205 1.0001132709021683 0.2932205914390226 0.931691048161812 0.09021535860267932 0.00011562121743853462 1.7042455189239603e-05 0.08736448878863591 0.029116881786537565 5.596768001038588e-11 10.252062695229593 -0.7068926794631456 ALQAAYGASAPSVTSAALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALQAAYGASAPSVTSAALR 19 0 O43488;H3BLU7 O43488 AKR7A2 Aflatoxin B1 aldehyde reductase member 2 0 24173000.0 6874700.0 11018000.0 6280300.0 False True 9012798.2746895 9374157.34782762 5630474.800891505 1.0 1.0400939932443536 0.6247199403878237 23.103543669840704 -6.883213643275126 1.0617451399239564 1.0260827608095116 0.593410412877058 0.9761852719403972 0.028869671129201836 0.12482012548193487 0.2554237283405535 0.020881867687153267 0.05093496453483074 1.3085380531356508e-07 6.883213643275126 -0.43267234793245357 ALQAAYGASAPSVTSAALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALQAAYGASAPSVTSAALR 19 0 O43488;H3BLU7 O43488 AKR7A2 Aflatoxin B1 aldehyde reductase member 2 0 19371000.0 5768500.0 2482500.0 11120000.0 False True 5585382.125017266 3473775.1960664745 8207338.407150706 1.0 0.6219404721670205 1.469431853263815 22.413224555674425 -6.785434388668199 1.5145519531317617 0.787443900320422 1.4773432411764806 0.7861948524731517 0.16029076319547578 0.24222016238926536 1.0976726374294343 0.08332778239024247 0.19575695087799055 1.6389496480055998e-07 6.785434388668199 0.6898993408560586 ALQAAYGASAPSVTSAALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALQAAYGASAPSVTSAALR 19 0 O43488;H3BLU7 O43488 AKR7A2 Aflatoxin B1 aldehyde reductase member 2 0 41100300.0 4055300.0 30992000.0 6053000.0 False True 6152186.5821421975 25461235.458398797 4856621.896875848 1.0 4.13856685236181 0.7894139477130044 22.55266782702076 -6.660763462026596 1.9697686850139986 3.0189431286556125 0.8032420645228844 0.2390047232503636 1.3360788381577071 0.4826505440562459 3.6006225174024724 0.5477974600769573 1.4816211124313987 2.1839190568991097e-07 6.660763462026596 -2.215701064132728 ALQAAYGASAPSVTSAALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALQAAYGASAPSVTSAALR 19 0 O43488;H3BLU7 O43488 AKR7A2 Aflatoxin B1 aldehyde reductase member 2 0 22218100.0 6874700.0 6577300.0 8766100.0 False True 9416462.371781953 6286693.137777484 6695727.723496582 1.0 0.6676279147694192 0.7110661583018142 23.166753731363595 -10.85707941937223 11.007711593941634 1.0082994051990684 0.6893470365356167 0.9855478475862436 0.017733588662853215 0.0035514161196350084 4.611034907776866e-05 0.016882665594136082 0.005723491129976932 1.3896984740062294e-11 10.85707941937223 -0.31895236866345167 ALQAAYGASAPSVTSAALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALQAAYGASAPSVTSAALR 19 0 O43488;H3BLU7 O43488 AKR7A2 Aflatoxin B1 aldehyde reductase member 2 0 14018600.0 5768500.0 5422000.0 2828100.0 False True 4796763.337879563 5392790.609817265 3419442.6343430285 1.0 1.1242561348046785 0.7128645700195443 22.1936298311087 -6.825709441063399 1.3470655829804006 1.0666146500457037 0.7027405829866287 0.8969990982507708 0.05529171615289166 0.18616627502720234 0.6621807105226738 0.03224185251300257 0.0742210647968053 1.4937934779582403e-07 6.825709441063399 -0.363874067059075 ALQATVGNSYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALQATVGNSYK 11 0 P11279;P11279-2 P11279 LAMP1 Lysosome-associated membrane glycoprotein 1 0 5407100.0 2683500.0 1571900.0 1151700.0 False True 3518094.48705097 1337378.6472182092 1032533.1318864933 1.0 0.3801429018295816 0.29349215482612306 21.746362799766025 -13.999999999999998 0.27719775243962524 5.974645985995664 0.2666780312003017 0.9995989942648523 0.006300348294995383 15.248693991131518 0.1667440036663211 42.93215542647497 0.034739080689242814 1.0000000000000041e-14 13.999999999999998 -5.707967954795363 ALQDEWDAVMLHSFTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALQDEWDAVMLHSFTLR 17 0 Q9UMS4;F5GY56 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 10906100.0 5589800.0 1712200.0 3604100.0 False True 5412354.858701829 2395890.3890050454 2660078.089317615 1.0 0.4426706030098898 0.4914825725147748 22.367825001415046 -10.216672401966154 8.397283096162836 1.000000140877273 0.4670765889980109 0.9937474039831915 0.01992740310454353 5.2568319429284785e-08 4.896141199947635e-09 0.019294630264342853 0.006431541696421601 6.071941770225693e-11 10.216672401966154 -0.5329235518792621 ALQDEWDAVMLHSFTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALQDEWDAVMLHSFTLR 17 0 Q9UMS4;F5GY56 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 10501900.0 5589800.0 2315800.0 2596300.0 False True 4648166.370127272 2303324.325749692 3139174.3260651324 1.0 0.4955339680938797 0.6753575659941747 22.148230276849322 -10.05309408906639 4.908842038710677 1.0000085993012389 0.5854457670409127 0.8763311872263935 0.07341267644316433 7.487398513047461e-06 1.4442357692994845e-06 0.07108311531472256 0.023693839436547688 8.849238720024648e-11 10.05309408906639 -0.4145628322603262 ALQDEWDAVMLHSFTLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALQDEWDAVMLHSFTLR 17 0 Q9UMS4;F5GY56 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 19611500.0 3566400.0 8467300.0 7577800.0 False True 4616775.104254047 7996087.311645102 6198718.154794017 1.0 1.7319637909754897 1.3426510962343208 22.138454025800723 -10.331299725642243 5.148727469521915 0.9998062385456303 1.5373074436049676 0.7174924699349134 0.1589362420841798 0.0003536276270874775 4.592817612059644e-05 0.15394402516803235 0.051296451558370246 4.6633742934721524e-11 10.331299725642243 0.5375012050593373 ALQEAEQSK(ub)VLSAVEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALQEAEQSKVLSAVEDR 17 1 Q96LD4 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 196824100.0 68610900.0 70317500.0 57895700.0 True False 89949554.3289008 59826403.095468156 51905208.33876946 1.0 0.6651106116291888 0.5770479767912792 26.42261279761628 -13.999999999999998 0.18751135432266897 2.7800463141482985 0.5122643041686743 0.9994909705561987 0.004110890940301499 12.311260797140264 0.13731650554189112 8.000542622926256 0.06178229537933809 1.0000000000000041e-14 13.999999999999998 -2.267782009979624 ALQEAEQSK(ub)VLSAVEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALQEAEQSKVLSAVEDR 17 1 Q96LD4 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 289558000.0 56600300.0 90170200.0 142787500.0 True False 54803554.457937784 126175631.09138118 105387170.21681952 1.0 2.3023256856126384 1.922998813839805 25.707766130983835 -10.126282930354323 5.011519728702409 0.9999552682442581 2.1126622497214185 0.9198202424425478 0.15485954694176798 8.050807765170212e-05 1.4035613748212502e-05 0.14994833678679212 0.04998070385693234 7.4768224834933e-11 10.126282930354323 1.1127069814771604 ALQEAEQSK(ub)VLSAVEDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALQEAEQSKVLSAVEDR 17 1 Q96LD4 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 680784000.0 138884000.0 231604000.0 310296000.0 True False 210697181.78044492 190272456.66968867 248965859.59243155 1.0 0.9030612325321008 1.181628807222795 27.65059577634587 -6.812719681100138 1.4032034592316411 0.947337877712646 1.186805467687837 0.8667883477446692 0.04214200679680925 0.20310873984314737 0.7876902687140588 0.02361223877794774 0.05455236470679955 1.5391477751846069e-07 6.812719681100138 0.23946758997519102 ALQEAEQSK(ub)VLSAVEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALQEAEQSKVLSAVEDR 17 1 Q96LD4 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 175862600.0 68610900.0 49141600.0 58110100.0 True False 93978203.86985542 46970361.62245998 44385691.19507631 1.0 0.49980058873551486 0.472297717634009 26.485822859139173 -13.978665693120425 0.41325311144477184 9.999999999987347 0.47115459416197575 0.9998553788615728 0.0029167300358720967 28.279207762672414 0.21335473576360126 229.159602895094 0.006793357601667916 1.0503506459977138e-14 13.978665693120425 -9.528845405825372 ALQEAEQSK(ub)VLSAVEDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALQEAEQSKVLSAVEDR 17 1 Q96LD4 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 213703200.0 56600300.0 84253400.0 72849500.0 True False 47065657.26843791 83799510.21120957 88081993.63196933 1.0 1.7804810359549632 1.871470595419409 25.48817140641811 -11.144802685580444 0.3824144373444591 6.126118545060794e-12 1.880968243103236 0.9995156787086233 0.008607859486021448 3.102667635035453 0.19017149904469338 2.696367153399597 0.024432571005450675 7.164688518934464e-12 11.144802685580444 1.8809682430971097 ALQEAEQSK(ub)VLSAVEDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALQEAEQSKVLSAVEDR 17 1 Q96LD4 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 668679000.0 138884000.0 197693000.0 332102000.0 True False 179788075.81292614 186691210.76388636 271662843.6542801 1.0 1.0383959554589322 1.5110170261622462 27.42172209843832 -6.923027576940365 0.8019318810392915 0.990666338699478 1.5928100289074176 0.9949820455439308 0.01646086909504822 0.09642219501003324 0.09661506361268474 0.014415239985456779 0.04451510460935143 1.1939122907140215e-07 6.923027576940365 0.6021436902079397 ALQFLEEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALQFLEEVK 9 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 17470700.0 3521700.0 6012600.0 7936400.0 False True 4616982.804191315 5115543.516931235 7115217.459324449 1.0 1.1079840956495062 1.5410968073923141 22.138518928448704 -6.944812820466326 0.6131626963578344 0.9952291601656577 1.6765293761537654 0.9987286804217366 0.008336871324757389 0.08563811167506583 0.04511642167194116 0.00844906307092075 0.036562205148544184 1.1355001071402759e-07 6.944812820466326 0.6813002159881077 ALQFLEEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALQFLEEVK 9 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 15216400.0 6031400.0 1646300.0 7538700.0 False True 5839936.508421443 2303676.1753410855 5564088.313847754 1.0 0.394469387127597 0.9527652065778619 22.47752125358641 -10.635992676916892 9.573850855544942 1.0001068501936174 0.6736172968527313 0.31303795479778296 0.22792331386369216 0.0005199869538537347 1.977043246228744e-05 0.22075682170187103 0.07356193323387379 2.312103776591643e-11 10.635992676916892 -0.32648955334088614 ALQFLEEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALQFLEEVK 9 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 20308800.0 3521700.0 10162000.0 6625100.0 False True 4823767.66036402 9713009.238759795 5060387.828217479 1.0 2.0135731906347276 1.0490529777787025 22.201728989971595 -6.634584801655915 2.064280067677181 1.665541473899254 1.0530354289533153 0.13402540783603567 0.4342735207739381 0.5472050699085482 4.449664085348213 0.17173108702792766 0.48085119860584985 2.3196112070362331e-07 6.634584801655915 -0.6125060449459387 ALQFLEEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALQFLEEVK 9 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 10310600.0 6031400.0 2125400.0 2153800.0 False True 5015376.336324306 2113950.048341131 2604149.621953964 1.0 0.4214938035717601 0.5192331437011376 22.257926529020686 -10.56112991116421 6.498031619255635 1.000745051364739 0.4703634736364488 0.9750947425501642 0.039901918518884416 0.0004312409892018366 2.912547342086924e-05 0.03868439046792281 0.012878288825447051 2.7470722943027797e-11 10.56112991116421 -0.5303815777282901 ALQGASQIIAEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALQGASQIIAEIR 13 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 6237600.0 1373800.0 3506700.0 1357100.0 False True 1801065.103898124 2983514.029009541 1216680.3102224192 1.0 1.65652758612234 0.6755337758691259 20.780418901247636 -6.726363653936937 1.7363753051804003 1.3967003010421029 0.6764918223362677 0.5422721848577152 0.2760789701205391 0.3431534631491705 2.0251327077696573 0.12608368850510987 0.31417796272040516 1.877743840543546e-07 6.726363653936937 -0.7202084787058352 ALQHSYLHK(ub)DEGNPE ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALQHSYLHKDEGNPE 15 1 P11802;P11802-2;F8VZ13 P11802 CDK4 Cyclin-dependent kinase 4 1 70928200.0 4933300.0 6272900.0 59722000.0 True False 7484176.772540167 5153451.9846086 47917920.522917494 1.0 0.688579671650312 6.402563966518112 22.835412204046005 -6.8940177992083616 0.9983331225172946 0.7218934204979165 6.934477464351572 0.9833470833988825 0.33852403082073146 0.11594295626845619 0.20329977678935174 0.2569127041465627 0.6504673021428203 1.276386496070336e-07 6.8940177992083616 6.2125840438536555 up ALQHSYLHK(ub)DEGNPE ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALQHSYLHKDEGNPE 15 1 P11802;P11802-2;F8VZ13 P11802 CDK4 Cyclin-dependent kinase 4 1 83202600.0 4933300.0 5920300.0 72349000.0 True False 6386254.099881255 5590830.100638047 59182224.36342909 1.0 0.8754474866169202 9.26712646221351 22.606538526138454 -6.903531625245996 0.9386642975539107 0.6841008854886836 10.213998765678037 0.9882430857766666 0.4257853271023563 0.10885242030448415 0.16311867989159626 0.33781154811656083 0.895579480828784 1.2487295090214124e-07 6.903531625245996 9.529897880189353 up ALQLAQRPVSLLASPWTSPTWLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALQLAQRPVSLLASPWTSPTWLK 23 1 A0A0G2JNZ5;A0A0G2JNZ0;A0A0G2JLB3;P04062-4;P04062-5;P04062-2;P04062;P04062-3 A0A0G2JNZ5 GBA Glucosylceramidase 0 21994900.0 9879200.0 7870100.0 4245600.0 False True 8214992.5227667 7827702.209207457 5133335.330563539 1.0 0.9528556705942309 0.6248740113076451 22.969827831368384 -6.932790398840182 0.7235211947592115 1.0045079659999177 0.5524927433003727 0.9970587819166296 0.009048119486050325 0.09121471049446153 0.07077061954784418 0.008384584689233783 0.029234706579780258 1.1673728838883296e-07 6.932790398840182 -0.45201522269954497 ALQLLQMYYEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALQLLQMYYEGR 12 0 A0A087WV29;Q9H0A0-2;Q9H0A0 A0A087WV29 NAT10 N-acetyltransferase 10 0 7651800.0 3143200.0 2956800.0 1551800.0 False True 4120765.6387921 2515656.9655161304 1391234.6219166985 1.0 0.610482901971958 0.33761556561719547 21.974480984564284 -8.086001670092585 0.20368919008664058 1.254431822010566 2.709093801858103e-19 0.9998058069868779 0.0037877741854784167 0.09312345000745002 0.03851159525974997 0.08803676034608068 0.10736517929118614 8.203483896491708e-09 8.086001670092585 -1.254431822010566 down ALQLLQMYYEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALQLLQMYYEGR 12 0 A0A087WV29;Q9H0A0-2;Q9H0A0 A0A087WV29 NAT10 N-acetyltransferase 10 0 12064200.0 3143200.0 4125300.0 4795700.0 False True 4305325.981786122 3943030.6054571774 3663054.430541811 1.0 0.9158494901752733 0.8508192982455987 22.037691046087176 -6.974001907837774 0.13111057119457 1.0990943775367639 0.6658899398432582 0.9999991824537248 5.491512214632862e-05 0.07502428370165348 0.003939787734332014 0.004042010355445672 0.008834975632810167 1.0616908932241082e-07 6.974001907837774 -0.4332044376935057 ALQLQLDGNGK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALQLQLDGNGKLR 13 1 Q86YV9 Q86YV9 HPS6 Hermansky-Pudlak syndrome 6 protein 1 7707400.0 1160600.0 2633800.0 3913000.0 True False 1521557.839266386 2240847.30647199 3508120.2961464333 1.0 1.472732254169455 2.3056108717088675 20.53711774565895 -6.962446475165799 0.39946165108089865 0.9539428620125661 2.854785409724954 0.9998504501253758 0.0066003949199409506 0.07883849374769461 0.017985139498590357 0.010717455801747117 0.06979563930039881 1.0903188609819889e-07 6.962446475165799 1.900842547712388 ALQLQLDGNGK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALQLQLDGNGKLR 13 1 Q86YV9 Q86YV9 HPS6 Hermansky-Pudlak syndrome 6 protein 1 15268000.0 2524600.0 3830100.0 8913300.0 True False 2444457.95489617 5359478.903707641 6578639.336731702 1.0 2.192501979006339 2.691246672316413 21.221083160276912 -9.701214621049532 0.23474299046012082 4.483213225802756e-19 3.0298374995805855 0.9991984619852665 0.020088323501762765 1.124823097254255 0.09917997452026349 1.0238290914174728 0.2390641823068771 1.9896898246462167e-10 9.701214621049532 3.0298374995805855 ALQLQLDGNGK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALQLQLDGNGKLR 13 1 Q86YV9 Q86YV9 HPS6 Hermansky-Pudlak syndrome 6 protein 1 9619500.0 1160600.0 2815300.0 5643600.0 True False 1589705.1840356854 2690910.737047874 4310697.913590461 1.0 1.6927105504032054 2.7116335512268765 20.60032780718184 -6.965580508755618 0.347945357708671 0.899176203011923 3.53944186565758 0.9999246166802159 0.006103598323406528 0.07776451733528064 0.014168435384153445 0.01406109079073821 0.08769990461728223 1.0824790284470337e-07 6.965580508755618 2.640265662645657 ALQLQLDGNGK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALQLQLDGNGKLR 13 1 Q86YV9 Q86YV9 HPS6 Hermansky-Pudlak syndrome 6 protein 1 13162600.0 2524600.0 5803000.0 4835000.0 True False 2099316.7587432987 5771738.0871946905 5845976.145485853 1.0 2.749341214543436 2.784704176317534 21.001488435711188 -10.650195103579593 0.7146253835243701 8.015949235900275e-18 2.778328831485977 0.9999540568195457 0.005646916802744004 2.1899147582294716 0.3655287304141116 3.8998655520140644 0.005438379292690124 2.2377156355511976e-11 10.650195103579593 2.778328831485977 ALQQFLYVQMAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALQQFLYVQMAK 12 0 Q7KZ85 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 38204500.0 3506100.0 28270000.0 6428400.0 False True 5319010.030244074 23224997.625481866 5157823.922332185 1.0 4.366413579486358 0.9696962203501444 22.34272632682522 -6.648262636581704 2.0149509351938817 3.1875221431591707 0.9840467373036367 0.1869130395886549 1.437451233554007 0.5128331547423897 3.98901174240464 0.5789942706216612 1.5918291225075296 2.2476949168037728e-07 6.648262636581704 -2.203475405855534 ALQQFLYVQMAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALQQFLYVQMAK 12 0 Q7KZ85 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 15020000.0 3506100.0 6813500.0 4700400.0 False True 4538715.565563351 6434322.735452134 3844975.4301768104 1.0 1.4176527791852271 0.8471505593674644 22.113852648917668 -6.710455626952831 1.7933941505980684 1.2566430431508784 0.8484626227327445 0.4673225596607814 0.1759841847140687 0.3741756111653809 2.346156392963671 0.07807871413099225 0.19826096390308132 1.9478000517993213e-07 6.710455626952831 -0.40818042041813385 ALQQLLFPGK(ub)AFSWPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALQQLLFPGKAFSWPR 16 1 Q8WUX1;A0A087X1I6;Q8WUX1-2 Q8WUX1 SLC38A5 Sodium-coupled neutral amino acid transporter 5 1 402206600.0 5926600.0 232080000.0 164200000.0 True False 8991085.492497224 190663510.7506836 131745798.02858345 1.0 21.20583892899097 14.65293574824988 23.100063871949914 -9.036274268054363 10.435205637469009 1.0000000000021163 17.929387338677838 0.8989823109421426 2.675211521218889 0.0 0.0 2.590262417267889 0.8634208057559628 9.198684678566329e-10 9.036274268054363 16.92938733867572 ALQQLLFPGK(ub)AFSWPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALQQLLFPGKAFSWPR 16 1 Q8WUX1;A0A087X1I6;Q8WUX1-2 Q8WUX1 SLC38A5 Sodium-coupled neutral amino acid transporter 5 1 299656600.0 5926600.0 179110000.0 114620000.0 True False 7672100.530751475 169142371.04965633 93760336.10051605 1.0 22.046422667650965 12.22094727835016 22.871190194042363 -9.594091172642075 8.85217984118293 0.9999999928430543 17.133684973000577 0.782372082011098 4.011233530676863 0.0 0.0 3.883860165515045 1.2946200551716813 2.546295645581956e-10 9.594091172642075 16.133684980157522 ALQQVQEK(ub)EVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALQQVQEKEVR 11 1 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 1 11237900.0 2190700.0 2302400.0 6744800.0 True False 2121157.4276285553 3221760.326857386 4978134.540337241 1.0 1.5188690310738981 2.3468953673574213 21.016420267811988 -6.964208015085298 0.37140075120137034 0.9373267848468962 2.9573231808881193 0.9998958678401655 0.005660187951014257 0.0782308313405268 0.015814368719148198 0.010891323224959391 0.07027121729947397 1.085905380292244e-07 6.964208015085298 2.019996396041223 ALQQVQEK(ub)EVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALQQVQEKEVR 11 1 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 1 11612500.0 5390600.0 3389700.0 2832200.0 True False 8177934.30564834 2784781.5511530167 2272414.4286026433 1.0 0.34052383487962506 0.2778714457308774 22.963305042888376 -13.999999999999998 0.3329271697758359 8.306801025613685 0.26715240903937376 0.9997208852916877 0.0054572541976526945 19.073561982777687 0.18467049624904686 97.73331127213751 0.019860333459788482 1.0000000000000041e-14 13.999999999999998 -8.039648616574311 ALQQVQEK(ub)EVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALQQVQEKEVR 11 1 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 1 12235700.0 5390600.0 4272800.0 2572300.0 True False 6978237.96461189 4035014.9239069363 2104167.7940268484 1.0 0.5782283356299032 0.3015328231421062 22.734431364980825 -8.341124460521634 0.21164883230326137 1.2730610456845 6.213203434753662e-11 0.9996925336238164 0.005035810583629245 0.10432938604581117 0.04890098528168254 0.12074232374533074 0.11687070269893546 4.559062431874923e-09 8.341124460521634 -1.2730610456223679 down ALQQYTLEPSEK(ub)PFDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALQQYTLEPSEKPFDLK 17 1 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 1 23250700.0 6361700.0 11880000.0 5009000.0 True False 8340250.306790444 10107550.30787729 4490716.729720796 1.0 1.2119001152337059 0.5384390833047967 22.991659251668732 -6.822136045119273 1.3627369989948712 1.1139701284476362 0.5230669704924704 0.8892023532433431 0.09358977055015771 0.19071775989036727 0.6953605817977236 0.05396248934653485 0.12430162455697438 1.5061351872049342e-07 6.822136045119273 -0.5909031579551658 ALQQYTLEPSEK(ub)PFDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALQQYTLEPSEKPFDLK 17 1 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 1 29619300.0 10185000.0 9067300.0 10367000.0 True False 9861682.749987133 12687920.175344838 7651571.696666493 1.0 1.286587745419147 0.7758890536887811 23.23340241145724 -6.754421329484698 1.63339475791527 1.16761391490157 0.7745153689475844 0.6678287535858392 0.12046218204342785 0.2923849158400474 1.5360408984863432 0.05822658382540233 0.14071339835065153 1.7602674995573092e-07 6.754421329484698 -0.39309854595398563 ALQQYTLEPSEK(ub)PFDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALQQYTLEPSEKPFDLK 17 1 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 1 88197000.0 25509000.0 31076000.0 31612000.0 True False 38699017.957701184 25530245.002103753 25363874.34396822 1.0 0.6597129940095335 0.6554139015023961 25.205793620619186 ALQQYTLEPSEK(ub)PFDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALQQYTLEPSEKPFDLK 17 1 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 1 22372500.0 6361700.0 9270600.0 6740200.0 True False 8713792.408478238 8860994.238225421 5148303.578776385 1.0 1.016892969541478 0.590822381052738 23.054869313191624 -6.8976683556365295 0.9759055748277021 1.0188654780741095 0.548160057003269 0.9853696957958463 0.023827159771273393 0.11314146254133679 0.18726392080393353 0.018389289973479123 0.04730915923320236 1.2657025187918686e-07 6.8976683556365295 -0.47070542107084057 ALQQYTLEPSEK(ub)PFDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALQQYTLEPSEKPFDLK 17 1 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 1 30077800.0 10185000.0 12778000.0 7114800.0 True False 8469278.77200369 12709162.377765588 8602471.784881644 1.0 1.500619204999768 1.0157266062983121 23.013807686891518 -10.554014737542301 4.235590246728493 0.9966665057953653 1.258172905649389 0.27430012217884714 0.19795657448007356 0.006305173812535989 0.0006639013089877856 0.1939399497479288 0.06389020968590757 2.792449079419213e-11 10.554014737542301 0.2615063998540238 ALQQYTLEPSEK(ub)PFDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALQQYTLEPSEKPFDLK 17 1 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 1 113123000.0 25509000.0 28134000.0 59480000.0 True False 33021903.357564114 26568318.168226372 48655250.31633829 1.0 0.8045665290865355 1.4734235573732655 24.976919942711636 -6.8285223668542 1.3347527637183032 0.8954657137493996 1.4908525528938044 0.902835484946354 0.08753225221976155 0.18264557363744105 0.636947089908214 0.05150133087858245 0.11851271197306834 1.4841494420475222e-07 6.8285223668542 0.5953868391444047 ALQSVGQIVGEVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALQSVGQIVGEVLK 14 0 A0A087X2I1;P62333;H0YJC0;H0YJE9;H0YJT1 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 0 7021600.0 1445200.0 3568200.0 2008200.0 False True 1894671.1953367104 3035838.4687346625 1800410.7280146347 1.0 1.6023035955825307 0.9502496963303839 20.853516071538042 -6.663984503156096 1.958942522775847 1.3864245815535108 0.9529572121052319 0.2525783222770398 0.2562065781372233 0.4750811448176808 3.508763383801338 0.10551874953278595 0.28412443164360607 2.1677814559555917e-07 6.663984503156096 -0.4334673694482789 ALQSVGQIVGEVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALQSVGQIVGEVLK 14 0 A0A087X2I1;P62333;H0YJC0;H0YJE9;H0YJT1 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 0 24714400.0 15094000.0 5225300.0 4395100.0 False True 14614849.23203787 7311789.53957952 3243891.459826265 1.0 0.5002986636051651 0.2219585989785775 23.800931610473995 -8.847001285271439 0.23399280252053384 1.3127034453055815 2.361374445185152e-15 0.9993627180544218 0.008125951545659248 0.35600093693456125 0.07292726188422056 0.20869456771171677 0.11986966999386943 1.4223245778225912e-09 8.847001285271439 -1.312703445305579 down ALQSVGQIVGEVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALQSVGQIVGEVLK 14 0 A0A087X2I1;P62333;H0YJC0;H0YJE9;H0YJT1 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 0 20096900.0 1445200.0 6581700.0 12070000.0 False True 1979529.4950615007 6290898.731228636 9219314.58945298 1.0 3.177976760095301 4.65732620425873 20.916726133060934 -8.1719861254567 0.2440827683036971 3.804157957245269e-16 5.98492387328171 0.9995318456447001 0.03250183183973351 0.09080696919728926 0.05287034218333282 0.4542830937594699 0.530745099338696 6.72998156426038e-09 8.1719861254567 5.98492387328171 ALQSVGQIVGEVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALQSVGQIVGEVLK 14 0 A0A087X2I1;P62333;H0YJC0;H0YJE9;H0YJT1 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 0 20603900.0 15094000.0 3170000.0 2339900.0 False True 12551329.777577184 3152922.5808042684 2829162.2715247874 1.0 0.2512022739165798 0.22540737289677906 23.58133688590827 ALQTTGTAK(ub)SHLFDGLDDDEPSLANGAFMPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALQTTGTAKSHLFDGLDDDEPSLANGAFMPK 31 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3;H0YEN4;H0YCR0 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 9998300.0 2829300.0 4410000.0 2759000.0 True False 2352688.3092420264 4386242.454683537 3335894.1438253233 1.0 1.8643534026386468 1.4179073916085636 21.165878770253325 -10.343822431422444 5.623047817386252 0.999869012901183 1.64113039712361 0.733315719942019 0.18226082078745973 0.00029935245808671555 3.4932701506162076e-05 0.17650882139910004 0.05882442696465799 4.530827925306392e-11 10.343822431422444 0.641261384222427 ALQWHPDK(ub)NPDNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALQWHPDKNPDNK 13 1 P25686;C9JRD2;P25686-2;C9JXB9;C9J1G2;E7ETU0;C9JX00 P25686 DNAJB2 DnaJ homolog subfamily B member 2 1 6377600.0 1105800.0 2067400.0 3204400.0 True False 1449714.5085824323 1758951.9786620836 2872839.4267752687 1.0 1.2133092193317645 1.9816587402332093 20.467337388457466 -6.947284191509662 0.5879030205205522 0.9910620019692707 2.242429278934426 0.9989705674412109 0.013526078644740678 0.08459494259538825 0.04061930934218872 0.01405346576175706 0.06432853496216645 1.1290568461604772e-07 6.947284191509662 1.251367276965155 ALQWHPDK(ub)NPDNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALQWHPDKNPDNK 13 1 P25686;C9JRD2;P25686-2;C9JXB9;C9J1G2;E7ETU0;C9JX00 P25686 DNAJB2 DnaJ homolog subfamily B member 2 1 24819000.0 5072800.0 2093300.0 17652900.0 True False 4911766.740710337 2929165.6064152927 13029075.914351705 1.0 0.5963568225130492 2.652625135139754 22.227810618222207 -6.855747586912976 1.2070293508050447 0.7830243656444486 2.744409789468051 0.9482579374761211 0.20235403721836906 0.15124869982349137 0.4211653238401412 0.13096225060002312 0.3043876845291762 1.393966744664667e-07 6.855747586912976 1.9613854238236024 up ALQWHPDK(ub)NPDNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALQWHPDKNPDNK 13 1 P25686;C9JRD2;P25686-2;C9JXB9;C9J1G2;E7ETU0;C9JX00 P25686 DNAJB2 DnaJ homolog subfamily B member 2 1 20125500.0 7156100.0 6758000.0 6211400.0 True False 10856326.880987315 5551982.099504993 4983714.067446668 1.0 0.5114052073384212 0.4590607967207257 23.372032729881933 -13.999999999999998 0.31549344401926765 5.877844976934169 0.44813818502222513 0.9996840001750449 0.0043303694505965745 17.67049445352113 0.17893589455265066 56.75456416888866 0.017740656653438998 1.0000000000000041e-14 13.999999999999998 -5.4297067919119435 ALQWHPDK(ub)NPDNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALQWHPDKNPDNK 13 1 P25686;C9JRD2;P25686-2;C9JXB9;C9J1G2;E7ETU0;C9JX00 P25686 DNAJB2 DnaJ homolog subfamily B member 2 1 16672600.0 1105800.0 5779000.0 9787800.0 True False 1514644.14312137 5523664.671402565 7476123.226068597 1.0 3.6468398841324063 4.935894190078103 20.530547449980357 -8.855803986251303 0.30115561341308567 5.569251967954682e-23 5.540623841433222 0.9986279666107545 0.06068728841822807 0.367157183848973 0.09898384606830107 0.8517518473675008 0.43199434090875977 1.3937857299369688e-09 8.855803986251303 5.540623841433222 ALQWHPDK(ub)NPDNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALQWHPDKNPDNK 13 1 P25686;C9JRD2;P25686-2;C9JXB9;C9J1G2;E7ETU0;C9JX00 P25686 DNAJB2 DnaJ homolog subfamily B member 2 1 20472700.0 5072800.0 10862400.0 4537500.0 True False 4218257.963143875 10803882.095182419 5486270.270970433 1.0 2.5612189177568143 1.3006009397494283 22.008215893656484 -6.593013933307476 2.2172889487340677 2.054671611174405 1.3043981882899844 0.0009689343032757147 0.676012334912087 0.6608173473634814 6.129262040799769 0.2540745058303309 0.7530043809740479 2.552619406613562e-07 6.593013933307476 -0.7502734228844208 ALQWHPDK(ub)NPDNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALQWHPDKNPDNK 13 1 P25686;C9JRD2;P25686-2;C9JXB9;C9J1G2;E7ETU0;C9JX00 P25686 DNAJB2 DnaJ homolog subfamily B member 2 1 23585200.0 7156100.0 12336600.0 4092500.0 True False 9263712.517819772 11650057.365257055 3347706.992596075 1.0 1.2576013496583456 0.3613785494915124 23.143159051974383 -6.829843827037583 1.3285644283866735 1.1376605361620695 0.33733100195791205 0.9055719599577869 0.11576961226305725 0.18100230901112815 0.6248769232053816 0.068418487316357 0.15745476435751127 1.4796403734609373e-07 6.829843827037583 -0.8003295342041574 down ALSDHHIYLEGTLLK(ub)PNMVTPGHACTQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALSDHHIYLEGTLLKPNMVTPGHACTQK 28 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 144469200.0 7275200.0 29704000.0 107490000.0 True False 11037010.288363608 24403089.121588733 86244554.3854594 1.0 2.211023500387335 7.81412285865019 23.39584609119306 -6.941549631246951 0.6449853065338536 0.9384033035572706 9.396571602462924 0.9983599183006495 0.12020719789515429 0.08706671975083977 0.05144313489014494 0.11843532221995437 0.479051033579176 1.144064128503605e-07 6.941549631246951 8.458168298905653 ALSDHHIYLEGTLLK(ub)PNMVTPGHACTQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALSDHHIYLEGTLLKPNMVTPGHACTQK 28 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 125921200.0 7275200.0 15229000.0 103417000.0 True False 9417889.815631744 14381492.762633085 84596167.14802887 1.0 1.527039819340718 8.982497014099355 23.16697241328551 -6.92115724670605 0.8160976170652974 0.8422606222778254 10.217353123515206 0.9944963737926937 0.27041817858760653 0.09749573134931439 0.10212092615207558 0.234431789869457 0.7101952958117316 1.1990650743493284e-07 6.92115724670605 9.375092501237381 up ALSDHHIYLEGTLLKPNMVTPGHACTQK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ALSDHHIYLEGTLLKPNMVTPGHACTQK 28 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 1383577400.0 411956000.0 458365400.0 513256000.0 False True 540078305.3875788 389979069.0143354 460149192.61920094 1.0 0.7220787525143654 0.8520045853146831 29.008593356382747 -10.06730678959585 4.582682802291317 1.0000110387354906 0.787041668905505 0.7817591708351134 0.053041999157284976 73604601.97979903 1.1546879160748773 8796.232988886428 0.018157687141602798 8.564326396410751e-11 10.06730678959585 -0.2129693698299856 ALSDHHIYLEGTLLKPNMVTPGHACTQK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ALSDHHIYLEGTLLKPNMVTPGHACTQK 28 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 647523000.0 328882300.0 106349600.0 212291100.0 False True 318442111.40756917 148815549.8858374 156685692.31351367 1.0 0.46732371302290066 0.49203822830132554 28.246455892410044 -10.394572120475463 5.895551155251121 1.0001402615632284 0.47968097066211746 0.9983107577615336 0.010089658612061616 1.860616286669729e-05 1.9107087892870817e-06 0.009771867655325622 0.003256423314452501 4.0311399835055696e-11 10.394572120475463 -0.520459290901111 ALSDHHIYLEGTLLKPNMVTPGHACTQK ddPTM_RPMI8226_Bortezomib_8h_R1 2 ALSDHHIYLEGTLLKPNMVTPGHACTQK 28 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 3209863000.0 650634000.0 1471316000.0 1087913000.0 False True 987059345.7168428 1208748164.3556232 872886518.7007937 1.0 1.2245952278358512 0.8843303317966844 29.878561586635186 -6.728692453677509 1.7279197231651025 1.1353569852739158 0.8845780146698375 0.55321234385368 0.09442472830345602 0.33870270235779765 1.9805449891301294 0.04331516028661511 0.10764630760897216 1.8677018386423619e-07 6.728692453677509 -0.2507789706040783 ALSDHHIYLEGTLLKPNMVTPGHACTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ALSDHHIYLEGTLLKPNMVTPGHACTQK 28 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 1364411600.0 411956000.0 383945400.0 568510200.0 False True 564267265.8923019 366981422.69034886 434239799.5950982 1.0 0.6503680877359139 0.7695640449892388 29.071803417905638 -10.941239498211742 11.26555108212244 1.0631654185631785 0.7099660663625764 0.8875683687529001 0.04866154577887358 0.025559359491749815 0.0001333160429486302 0.015599183394109803 0.015705446366857265 1.14488140528841e-11 10.941239498211742 -0.35319935220060206 ALSDHHIYLEGTLLKPNMVTPGHACTQK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ALSDHHIYLEGTLLKPNMVTPGHACTQK 28 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 629440500.0 328882300.0 90853300.0 209704900.0 False True 273480204.406259 90363855.23993199 253553225.02409387 1.0 0.33042192372247575 0.9271355693717294 28.02686116784432 -10.584323569637464 9.225296415092846 1.0000543118442158 0.628778746547128 0.34038116034046695 0.24360732573276714 0.0002721635693874567 1.2263510192845337e-05 0.2359059721494438 0.07862392629809435 2.6042125672465526e-11 10.584323569637464 -0.37127556529708783 ALSDHHIYLEGTLLKPNMVTPGHACTQK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ALSDHHIYLEGTLLKPNMVTPGHACTQK 28 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 2935990000.0 650634000.0 1304956000.0 980400000.0 False True 842258538.9135349 1232334051.451483 801977259.7534982 1.0 1.4631303744823094 0.9521746859200773 29.649687908727635 -6.668097106638436 1.944755008240636 1.2961052703809532 0.9542839251055697 0.2704272500200914 0.196815853870856 0.4654669172831904 3.3922841247849314 0.08154010281368979 0.21834614124747562 2.1473502808743026e-07 6.668097106638436 -0.34182134527538355 ALSDK(ub)QSLPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALSDKQSLPLR 11 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34 1 3964170.0 1124500.0 947970.0 1891700.0 True False 1088803.363020181 1326499.364598244 1396207.020216457 1.0 1.2183093932762379 1.2823316566028813 20.05431199738181 -13.70146188053146 0.17526299374096932 6.833443198921495e-08 1.3364461104810923 0.9994983343340694 0.0027070522396008905 10.853012877686501 0.1306566585190637 3.715956451838638 0.049800653751598305 1.988557345017108e-14 13.70146188053146 1.3364460421466604 ALSDK(ub)QSLPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALSDKQSLPLR 11 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34 1 3953300.0 1574100.0 1115700.0 1263500.0 True False 2156087.308453021 1066404.6848734803 965087.3225993232 1.0 0.49460180981196855 0.4476105020495516 21.039984168992454 -13.999999999999998 0.3360614675739612 6.707023206491013 0.43986753650663907 0.999727280875425 0.004129537936495969 19.34835103756892 0.18571812130551113 78.28863664295423 0.014726022759824528 1.0000000000000041e-14 13.999999999999998 -6.2671556699843745 ALSDK(ub)QSLPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALSDKQSLPLR 11 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34 1 4098200.0 1124500.0 1759200.0 1214500.0 True False 935071.5737965791 1749722.8404261395 1468446.3347864668 1.0 1.8712180858219356 1.570410625172016 19.834717272816086 -10.034723824104434 4.957427735523182 0.9999901998484869 1.7208143555007893 0.884474717291047 0.12280413159871577 84929817.6576644 4.013893165128975 11456.941080431443 0.04203912064012311 9.231582939729795e-11 10.034723824104434 0.7208241556523024 ALSEK(ub)SAPEVTAPGAPAYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALSEKSAPEVTAPGAPAYR 19 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;Q9UES5;O95317 G3V394 MYO5A Unconventional myosin-Va 1 10532900.0 2935000.0 2931300.0 4666600.0 True False 2841830.0315377736 4101783.376527557 3444277.4650008595 1.0 1.4433598529845912 1.2119927746477819 21.438388839601405 -10.059820808104982 4.224903402778009 0.999966662541706 1.3276763136916232 0.7278464231364534 0.09445521447051249 12088390.651167547 7195848.605388984 3564.2255385532167 0.03233453173075052 8.713230276754826e-11 10.059820808104982 0.32770965114991724 ALSEK(ub)SAPEVTAPGAPAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALSEKSAPEVTAPGAPAYR 19 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;Q9UES5;O95317 G3V394 MYO5A Unconventional myosin-Va 1 10909000.0 2935000.0 4945500.0 3028500.0 True False 2440582.5425459812 4918857.60989511 3661745.3477981137 1.0 2.015444068842608 1.5003571008003003 21.21879411503568 -10.157781402939529 4.700366492697849 0.9999174864740674 1.7579005848267597 0.7427125220123656 0.21028337416632922 0.0001836800595861966 3.291155283121879e-05 0.20362821771552345 0.06786866717430207 6.953742380268739e-11 10.157781402939529 0.7579830983526923 ALSEK(ub)SAPEVTAPGAPAYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALSEKSAPEVTAPGAPAYR 19 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;Q9UES5;O95317 G3V394 MYO5A Unconventional myosin-Va 1 17914300.0 5302300.0 5630900.0 6981100.0 True False 6863931.873958681 5317535.465041082 5710611.432134987 1.0 0.774706911823451 0.8319737924265656 22.710603803165462 -9.938536145857793 5.28906884075447 1.0000004781452665 0.8033403521237271 0.9402055804191024 0.02337910611090288 1.3180644591560655e-07 2.6466995377463524e-08 0.022636777133653457 0.007545574050748459 1.1520301736161405e-10 9.938536145857793 -0.19666012602153937 ALSGYCGFMAANLYAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALSGYCGFMAANLYAR 16 0 P53618 P53618 COPB1 Coatomer subunit beta 0 32468700.0 5668700.0 14674000.0 12126000.0 False True 8599832.337481702 12055310.05151471 9729290.784985395 1.0 1.4018075676862416 1.131334938075599 23.03587710259919 -10.480367505614472 5.338616954467776 0.9995515701988259 1.266571252880922 0.5642978626785016 0.1104199886558167 0.0005903224966049213 5.745894530661037e-05 0.10709027805794197 0.03563789809603155 3.30851032563767e-11 10.480367505614472 0.2670196826820962 ALSGYCGFMAANLYAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALSGYCGFMAANLYAR 16 0 P53618 P53618 COPB1 Coatomer subunit beta 0 23895400.0 5668700.0 9636000.0 8590700.0 False True 7338243.896782458 9099748.129275244 7027280.74802568 1.0 1.2400443835431987 0.9576243099669768 22.80700342469164 -6.681559970670338 1.8965627112714918 1.1516700746769115 0.9586924119984961 0.3311372864003861 0.1017027496827674 0.4350928656435139 3.0271794851402474 0.04301000079714897 0.11320075857501445 2.0818049139861038e-07 6.681559970670338 -0.19297766267841543 ALSHK(ub)ELYER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALSHKELYER 10 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3;Q9Y4W2-4 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 9966370.0 944870.0 1752600.0 7268900.0 True False 914875.61904569 2452422.319688263 5364957.027674259 1.0 2.680607361956364 5.864138158223589 19.803216091075615 -6.9610930582928106 0.41974567661574463 0.8588963866176773 7.805889705100602 0.9998086130065532 0.02790545270776552 0.07931296306471472 0.01970557845407839 0.041175070793819345 0.2650233064958827 1.0937219842798914e-07 6.9610930582928106 6.946993318482925 ALSHK(ub)ELYER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALSHKELYER 10 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3;Q9Y4W2-4 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 10964370.0 944870.0 3501900.0 6517600.0 True False 785701.269838305 3483034.5696272743 7880400.026022458 1.0 4.433026524628212 10.029766182819358 19.58362136650989 -6.963836613428062 0.3774909364925506 0.6045462700241672 14.055374478254839 0.9998871124187916 0.03954036959686353 0.07835804008632848 0.016266052576554384 0.07303549516102291 0.47349653684468057 1.0868344263075155e-07 6.963836613428062 13.450828208230671 ALSITLVQEPPPVSTVVHFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALSITLVQEPPPVSTVVHFK 20 0 Q68CZ2;Q68CZ2-2 Q68CZ2 TNS3 Tensin-3 0 23259500.0 8199400.0 8012600.0 7047500.0 False True 12439089.25643399 6582688.927270457 5654558.535971014 1.0 0.529193801215441 0.45457978630117574 23.568377524814668 -13.999999999999998 0.2592823220606046 4.433668011068496 0.42712080742629555 0.9995608725929672 0.005059795508862972 14.385523417063473 0.1611331539033086 25.86979214796575 0.03274402976731533 1.0000000000000041e-14 13.999999999999998 -4.006547203642201 ALSITLVQEPPPVSTVVHFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALSITLVQEPPPVSTVVHFK 20 0 Q68CZ2;Q68CZ2-2 Q68CZ2 TNS3 Tensin-3 0 3878800.0 1151700.0 1337300.0 1389800.0 False True 957689.5789608888 1330095.6994667328 1680400.7542908438 1.0 1.388858904479165 1.7546403252232423 19.86919857771901 -6.9718644518473205 0.2089094825052961 0.8058076198623981 2.3478903484301306 0.9999935036966187 0.0007853323311776895 0.0757022398316694 0.006821136396858684 0.011048908405134556 0.03800004083451951 1.066929069734134e-07 6.9718644518473205 1.5420827285677325 ALSNLESIPGGYNALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALSNLESIPGGYNALR 16 0 Q9NRR5;H0YDS0;Q9UMX0-2;Q9UMX0;Q9UMX0-3 Q9NRR5;Q9UMX0-2 UBQLN4;UBQLN1 Ubiquilin-4;Ubiquilin-1 0 8380600.0 1884500.0 1145300.0 5350800.0 False True 1824677.579023149 1602624.2626606007 3949264.9594408306 1.0 0.8783054502804677 2.1643631756329746 20.79921013126835 -6.883709251745999 1.0588492491463752 0.9201236916005306 2.2622624783356406 0.9765581921707402 0.08875662435814761 0.12439719723727695 0.25283685655439914 0.06433817416346009 0.15716759525894292 1.3070456265204745e-07 6.883709251745999 1.34213878673511 up ALSPLEEWLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALSPLEEWLR 10 0 P26640;A0A140T936;A0A140T954;A2ABF4;A0A0G2JJT9;A0A140T904 P26640 VARS Valine--tRNA ligase 0 5849260.0 934160.0 2206300.0 2708800.0 False True 1224692.8064183071 1877128.6400900425 2428519.3606443815 1.0 1.5327342744666117 1.9829620521302338 20.22398848815593 -6.973072411922062 0.16941728293363317 0.5990793491875958 2.9286674035622333 0.9999975002565747 0.0006351850478754705 0.07531777401485407 0.005281237426865604 0.019075782336996274 0.05226484837632869 1.0639656035417412e-07 6.973072411922062 2.3295880543746375 ALSSVGLHMTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALSSVGLHMTK 11 0 A0A499FI31;Q15020-4;Q15020;Q15020-2;F8VVK9;F8VZM2;A0A494C0L2;F8W667 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 10571800.0 4117100.0 2526400.0 3928300.0 False True 5397557.970053112 2149470.9678300675 3521837.1989144003 1.0 0.3982302700139257 0.6524871466789907 22.36387540227488 -10.348830868379325 5.850547261180474 1.0000735647456305 0.525358708346474 0.8228986084017794 0.10379993523719752 9.961666365077227e-05 1.1087366782963352e-05 0.10051933187596439 0.03350128504258901 4.4788769557777756e-11 10.348830868379325 -0.47471485639915645 ALSSVGLHMTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALSSVGLHMTK 11 0 A0A499FI31;Q15020-4;Q15020;Q15020-2;F8VVK9;F8VZM2;A0A494C0L2;F8W667 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 6456190.0 2212900.0 867190.0 3376100.0 False True 2142652.7007802175 1213463.489336107 2491798.1291710036 1.0 0.5663369938087683 1.1629500797136416 21.030966594109124 -6.711768904766201 1.788626992914549 0.7338712251509615 1.1616358477277753 0.4735085800562596 0.18269488533161346 0.3715913534915576 2.318360377085856 0.08124549576455051 0.20598125752789068 1.9419189297048318e-07 6.711768904766201 0.4277646225768138 ALSSVGLHMTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALSSVGLHMTK 11 0 A0A499FI31;Q15020-4;Q15020;Q15020-2;F8VVK9;F8VZM2;A0A494C0L2;F8W667 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 5010260.0 993760.0 2407000.0 1609500.0 False True 1507606.5735875592 1977452.0440231645 1291381.6195310897 1.0 1.3116499215823547 0.8565773340043669 20.523828560007864 -6.722399376968876 1.751038021031591 1.1891186011000343 0.8572055622676621 0.5236908681346246 0.1311059436197562 0.3506581453167234 2.102553738927342 0.05942579694665312 0.14874155559535435 1.8949625132210495e-07 6.722399376968876 -0.3319130388323722 ALSSVGLHMTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALSSVGLHMTK 11 0 A0A499FI31;Q15020-4;Q15020;Q15020-2;F8VVK9;F8VZM2;A0A494C0L2;F8W667 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 8916600.0 4117100.0 2079000.0 2720500.0 False True 5639303.130444015 1987142.9056663685 2077973.930456242 1.0 0.35237384118237836 0.3684806229404857 22.42708546379777 -10.120276778580472 6.1776372411834295 1.0000023511423342 0.3604272320614262 0.9995245633138189 0.006575566117642694 2.129331732961502e-07 3.033100463619667e-08 0.006366787942569303 0.0021222548387899373 7.580942828309821e-11 10.120276778580472 -0.639575119080908 ALSSVGLHMTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALSSVGLHMTK 11 0 A0A499FI31;Q15020-4;Q15020;Q15020-2;F8VVK9;F8VZM2;A0A494C0L2;F8W667 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 3300400.0 2212900.0 1087500.0 0.0 False True 1840124.3980919938 1081641.4216481505 0.0 1.0 0.5878088583411499 0.0 20.8113718695434 -7.682342560872252 0.6522633858991823 0.9995457820133835 3.546889021441359e-15 0.9874011892735174 0.04605853693720759 0.12050179159445869 0.15030310494977464 0.042709095083386696 0.0777743912832617 2.0780569199782145e-08 7.682342560872252 -0.99954578201338 down ALSTGEK(ub)GFGYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALSTGEKGFGYK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 15777400.0 3723900.0 7681500.0 4372000.0 True False 4882068.962298897 6535450.142252481 3919627.37918533 1.0 1.3386640362357827 0.8028619442810232 22.21906124356326 -6.735879671143311 1.7016699740398762 1.2024598923720962 0.8028154781681897 0.5863353480868974 0.14231321100953762 0.3253320616683536 1.848045380325515 0.06620382037909674 0.1632058331214885 1.8370472588089925e-07 6.735879671143311 -0.3996444142039065 ALSTGEK(ub)GFGYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALSTGEKGFGYK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 41598100.0 10347900.0 9999600.0 21250600.0 True False 10019411.57865409 13992492.427225111 15684430.35566518 1.0 1.3965383413368797 1.5654043386220564 23.256294448444784 -11.71536801714764 0.14687499688088299 8.349665493303566e-17 1.7862186024646514 0.9996272049494378 0.004575604358714804 4.747664432325565 0.09650095764107056 1.66032883946166 0.1679448982388351 1.9258922381709413e-12 11.71536801714764 1.7862186024646514 ALSTGEK(ub)GFGYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALSTGEKGFGYK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 49576000.0 10634100.0 12007900.0 26934000.0 True False 16132707.156846216 9864996.426849086 21610483.09440842 1.0 0.6114904542020829 1.3395447449895355 23.943485215169314 -6.761767977703946 1.606017943243846 0.7748229572884153 1.3424192163824669 0.69804274364206 0.16345116682339444 0.2799700020050724 1.4236568276941177 0.08028865972268866 0.192595333273357 1.7307407623831573e-07 6.761767977703946 0.5675962590940515 ALSTGEK(ub)GFGYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALSTGEKGFGYK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 13790900.0 3723900.0 6215400.0 3851600.0 True False 5100726.464613557 5940783.07642076 2941931.4061919726 1.0 1.1646935230961943 0.5767671382893613 22.28227130508615 -6.83193690570576 1.3193321577967396 1.0878878047678522 0.5603222006984523 0.9096763813386122 0.0744239189388312 0.17843268815495328 0.6067545776205143 0.044283224876785474 0.10190100251519738 1.4725264155039105e-07 6.83193690570576 -0.5275656040693999 ALSTGEK(ub)GFGYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALSTGEKGFGYK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 30690800.0 10347900.0 20342900.0 0.0 True False 8604737.339697301 20233308.759950507 0.0 1.0 2.351415035832143 0.0 23.03669972387906 -6.7530769464327305 1.6530459603343561 1.7937361243737235 2.0213229733231044e-12 0.6525103387773217 0.5679829096279828 0.29679923053553225 1.5991082550199844 0.27202095422424033 0.6545190307288532 1.765724949400641e-07 6.7530769464327305 -1.7937361243717023 ALSTGEK(ub)GFGYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALSTGEKGFGYK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 35733500.0 10634100.0 6371700.0 18727700.0 True False 13766052.079449315 6017109.293825546 15319450.762429211 1.0 0.4370976703486545 1.112842714382789 23.714611537261764 -6.685611756101432 1.881831325711508 0.6456587724847068 1.110402827830967 0.35004223242944976 0.23828375120501677 0.4261734761814525 2.922466991937626 0.10142464470033528 0.2656044124251402 2.0624728671385828e-07 6.685611756101432 0.4647440553462602 ALSTTASTAAFDK(ub)QPQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALSTTASTAAFDKQPQSR 18 1 C9J8T0;P57772 C9J8T0 EEFSEC Selenocysteine-specific elongation factor 1 4925300.0 863500.0 2239800.0 1822000.0 True False 718038.5095361 2227733.752834511 2202971.776023827 1.0 3.1025268467477787 3.068041263479157 19.45370169456719 -10.243185538490206 5.200843093135197 0.9997584027661987 3.085284055113994 0.999794922993117 0.014078680416899211 3.944352319953702e-05 5.739704284516853e-06 0.013633086464302903 0.004543874565671427 5.7123454276363126e-11 10.243185538490206 2.0855256523477954 ALSTWK(ub)QMGEQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALSTWKQMGEQR 12 1 P00491 P00491 PNP Purine nucleoside phosphorylase 1 7168700.0 3025300.0 1936400.0 2207000.0 True False 2515670.9935142617 1925968.2288546928 2668473.495984956 1.0 0.7655882799539757 1.0607402569193825 21.262511824187456 -6.695085833909862 1.8483747282612943 0.8537450111204119 1.0597866303772931 0.3943191832839431 0.09903969417995069 0.40582526498213733 2.6919546688374814 0.042803586442469385 0.11075300070528019 2.0179674934106153e-07 6.695085833909862 0.20604161925688125 ALSVGNIDDALQCYSEAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALSVGNIDDALQCYSEAIK 19 0 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 5862030.0 879130.0 4102000.0 880900.0 False True 1152547.9435070315 3489997.589470766 789752.9181894702 1.0 3.0280715081155094 0.6852234847483827 20.136395334227117 -6.677749658672679 1.9098049982050906 2.2857563978709416 0.6942704203366359 0.31390034787082766 0.8599688632941197 0.4435345946399063 3.125711517372077 0.36157269683964455 0.9564090699592246 2.10015012895473e-07 6.677749658672679 -1.5914859775343058 ALSVGNIDDALQCYSEAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALSVGNIDDALQCYSEAIK 19 0 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 15661800.0 7578400.0 5064100.0 3019300.0 False True 7337827.840206434 7086221.538932633 2228454.752941563 1.0 0.9657110650790734 0.30369406334816246 22.8069216258602 -6.917636403465414 0.8420829421767558 1.015888357709853 0.20253769573542893 0.9934984488888344 0.025839850066970843 0.09958264038947438 0.11297234832916002 0.021989333931640872 0.06444991179093233 1.2088254547063962e-07 6.917636403465414 -0.8133506619744241 down ALSVGNIDDALQCYSEAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALSVGNIDDALQCYSEAIK 19 0 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 5074280.0 879130.0 891650.0 3303500.0 False True 1204168.1185949466 852253.9547077528 2523281.3377181385 1.0 0.7077532958621957 2.0954560237505424 20.19960539575001 -6.85169565935343 1.226812242242442 0.8437825358858047 2.1527916810687766 0.9427404797532919 0.14293314658004244 0.1556069307606509 0.4498148629324656 0.0911229609777357 0.21111396686971337 1.4070331857060147e-07 6.85169565935343 1.309009145182972 up ALTCFSVLFLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALTCFSVLFLPK 12 0 Q9UII4;E9PBL0 Q9UII4 HERC5 E3 ISG15--protein ligase HERC5 0 2371530.0 465380.0 751350.0 1154800.0 False True 637443.5624216163 718152.8726178101 882060.0238525514 1.0 1.1266140486062535 1.38374606922321 19.281938089633716 -6.959744550542521 0.43902011130608165 0.990711555932659 1.5296574552999944 0.9997606036723156 0.0024702537328093912 0.0797925209999171 0.02146953480337976 0.0033860521022369954 0.021308992102856392 1.0971233278757197e-07 6.959744550542521 0.5389458993673354 ALTCFSVLFLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALTCFSVLFLPK 12 0 Q9UII4;E9PBL0 Q9UII4 HERC5 E3 ISG15--protein ligase HERC5 0 6150300.0 3177300.0 2973000.0 0.0 False True 4113077.4839463867 2807549.9365229625 0.0 1.0 0.682591064107354 0.0 21.97178681953647 -7.464162227079121 0.7306975977210676 0.9920253808062637 2.4092961788080468e-17 0.9871723958393008 0.04725432099919797 0.1173115801889927 0.14103119202808598 0.04141715463825842 0.07475026804671056 3.434296386616639e-08 7.464162227079121 -0.9920253808062637 down ALTDKVTDLLGGLFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALTDKVTDLLGGLFSK 16 1 O43615;M0QXU7 O43615 TIMM44 Mitochondrial import inner membrane translocase subunit TIM44 0 45646900.0 10605000.0 9154900.0 25887000.0 False True 16088560.329351248 7521136.567439828 20770423.103324834 1.0 0.46748350464389304 1.291005700829067 23.939531897753803 -6.7321385694686935 1.7152286677127062 0.6802899907823617 1.2907239744403922 0.5691369535460088 0.22382416655191792 0.3322965243111084 1.9161604735892928 0.10336406508285821 0.2558922243670382 1.8529403151386336e-07 6.7321385694686935 0.6104339836580305 ALTDKVTDLLGGLFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALTDKVTDLLGGLFSK 16 1 O43615;M0QXU7 O43615 TIMM44 Mitochondrial import inner membrane translocase subunit TIM44 0 29833400.0 10605000.0 6505400.0 12723000.0 False True 13728381.555802556 6143368.771293808 10407544.54900424 1.0 0.44749402879884254 0.7581042606297097 23.710658219846252 -10.18174933878852 5.581241218031862 1.0000107685160065 0.6027991447142552 0.6855698714091145 0.12680609614564362 1.699185142595724e-05 2.491122430139345e-06 0.12278280026340958 0.040926491547455514 6.580375264816057e-11 10.18174933878852 -0.39721162380175123 ALTDYK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALTDYKK 7 1 A0A1X7SBW3;Q5TA31 A0A1X7SBW3 RNF187 E3 ubiquitin-protein ligase RNF187 1 14094680.0 518210.0 915470.0 12661000.0 True False 679378.3283527792 778885.4444741107 11350961.172887798 1.0 1.1464678986193106 16.707864674472823 19.373855672523455 -6.9089610206199525 0.9027918602489828 0.502213982688273 18.67478181616979 0.9905232871425769 0.7175043273045735 0.1051088040840087 0.14252783173136893 0.5844291884960781 1.6018869890807172 1.233215513472447e-07 6.9089610206199525 18.17256783348152 up ALTDYK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALTDYKK 7 1 A0A1X7SBW3;Q5TA31 A0A1X7SBW3 RNF187 E3 ubiquitin-protein ligase RNF187 1 15572620.0 479620.0 4501000.0 10592000.0 True False 727618.6049187584 3697761.383526491 8498486.55736149 1.0 5.082004993453076 11.67986428591993 19.472822907037077 -6.963986644892762 0.3750444011663775 0.5207657533355311 16.472594586558348 0.9998906984738449 0.04600269228686703 0.07830661691420197 0.016083350489059036 0.08635504331473957 0.5588772797592271 1.0864590330993568e-07 6.963986644892762 15.951828833222816 ALTDYK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALTDYKK 7 1 A0A1X7SBW3;Q5TA31 A0A1X7SBW3 RNF187 E3 ubiquitin-protein ligase RNF187 1 13631650.0 518210.0 477440.0 12636000.0 True False 709806.2410986853 456345.1221170515 9651637.046588898 1.0 0.6429150600460911 13.59756576900402 19.437065734046346 -6.900560531998775 0.9577043846990694 0.46964599442336463 14.973023847153527 0.986843503196839 0.691018448898366 0.11099428389938432 0.17509635876217688 0.5405739840844318 1.4104983833979814 1.2573015993593898e-07 6.900560531998775 14.503377852730162 up ALTDYK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALTDYKK 7 1 A0A1X7SBW3;Q5TA31 A0A1X7SBW3 RNF187 E3 ubiquitin-protein ligase RNF187 1 8451820.0 479620.0 3835400.0 4136800.0 True False 620877.544723622 3621956.618412441 3383944.847152457 1.0 5.833608654706174 5.450261288896813 19.243949229129527 -10.169986256142638 5.157034204953349 0.9997566172556017 5.641934971804998 0.9949110010724413 0.15650090675771308 0.0004379531220702658 7.048793296386682e-05 0.15153800145923654 0.05051045045982576 6.761043713235368e-11 10.169986256142638 4.642178354549396 ALTGGIAHLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALTGGIAHLFK 11 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 61478000.0 15440000.0 14689000.0 31349000.0 False True 20241989.5211727 12497458.457273548 28105306.200841952 1.0 0.6174026739911839 1.388465603711749 24.270847759148403 -6.771775751359345 1.5675167709918771 0.7810503168968138 1.393111152196865 0.7373521127360203 0.16132636449207313 0.2635693788773388 1.278316626262469 0.08110847342551415 0.19277003839721815 1.6913140188748913e-07 6.771775751359345 0.6120608353000513 ALTGGIAHLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALTGGIAHLFK 11 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 40289500.0 13271000.0 4317500.0 22701000.0 False True 12849719.36917812 6041500.265465067 16754927.084597863 1.0 0.47016593062385975 1.3039138523746239 23.615233516306485 -6.734998271149585 1.7048708181751318 0.6829363553239806 1.303900246358 0.5823125033084804 0.22265657267854577 0.3269581505214446 1.8639038415271145 0.10339997629393491 0.2551542065441007 1.840779329275102e-07 6.734998271149585 0.6209638910340195 ALTGGIAHLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALTGGIAHLFK 11 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 27074400.0 8560700.0 11557000.0 6956700.0 False True 12987207.771002093 9494563.054746859 5581705.195770077 1.0 0.731070390353373 0.4297848540032553 23.63058795119902 -6.969653922545549 0.26632095334069367 1.0783177794811758 0.07352414431101535 0.9999795561565978 0.001053102885215706 0.07641513582381289 0.00943115609718796 0.006041804683652291 0.028165707129949105 1.072373510114489e-07 6.969653922545549 -1.0047936351701605 down ALTGGIAHLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALTGGIAHLFK 11 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 47133000.0 15440000.0 13879000.0 17814000.0 False True 21148585.25031106 13265779.888284523 13606700.09084635 1.0 0.6272655939521725 0.6433858307683356 24.334057820671294 -10.084968661655825 7.6253581806295765 1.00000003841169 0.6353257123675791 0.9985366165422778 0.006581059122071186 4.2980142915079565e-09 5.167606979842769e-10 0.006372083712228464 0.002124027698349008 8.223019844630381e-11 10.084968661655825 -0.364674326044111 ALTGGIAHLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALTGGIAHLFK 11 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 32476000.0 13271000.0 10815000.0 8390000.0 False True 11035424.504983887 10756737.44839057 10144310.209023023 1.0 0.9747461408061416 0.9192496586281377 23.39563879174076 -6.958165755146189 0.4606128894265274 1.0016077692391834 0.8901487828360217 0.9996957922723541 0.0005882412737138461 0.0803638260947561 0.023608081882108632 0.0007544904831996447 0.004584224407936398 1.1011189703983012e-07 6.958165755146189 -0.11145898640316165 ALTGGIAHLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALTGGIAHLFK 11 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 30471600.0 8560700.0 13387000.0 8523900.0 False True 11081994.906625075 12642001.68188125 6972637.662599795 1.0 1.1407694903670789 0.6291861457571496 23.401714273291468 -6.833352067833901 1.3129786864174886 1.0750590537628628 0.6144640035624371 0.9123938569602903 0.06386632719306004 0.17671116580890311 0.5946077708819738 0.03817922099369006 0.08785827113979919 1.4677359513833083e-07 6.833352067833901 -0.4605950502004257 ALTHFLK(ub)AAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALTHFLKAAR 10 1 Q6PGP7;D6RCE2 Q6PGP7 TTC37 Tetratricopeptide repeat protein 37 1 4354240.0 481930.0 823610.0 3048700.0 True False 623867.8852605303 777775.3794886235 2493867.882303642 1.0 1.2466988570245456 3.997429489838527 19.250881020416028 -6.924481319422485 0.7907797639302565 0.9485366747185054 4.49019916513838 0.9953379281922292 0.09276383607383872 0.09560621564172128 0.09247260359463573 0.08188511749807079 0.25685839922445863 1.1899225109331751e-07 6.924481319422485 3.5416624904198746 up ALTLGALTLPLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALTLGALTLPLAR 13 0 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 0 7071800.0 1596100.0 4134300.0 1341400.0 False True 2092502.556654389 3517478.5553751793 1202604.7956173837 1.0 1.6809912820365305 0.5747208249724559 20.99679795480964 -6.74018436691775 1.6862943979920766 1.4051047959355323 0.5740797415623375 0.605668445032199 0.28612102105181936 0.31747500064456846 1.7727134881782682 0.13423336991685927 0.32929521204310946 1.8189285222096217e-07 6.74018436691775 -0.8310250543731947 ALTLGALTLPLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALTLGALTLPLAR 13 0 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 0 5360300.0 2915300.0 1346900.0 1098100.0 False True 2822755.3972545387 1884724.1939907107 810474.6677061336 1.0 0.6676895191924268 0.28712182022374855 21.42867268838562 -7.283580327826549 0.32514639652077243 1.0612578421686396 5.308593811916249e-12 0.9998175763026834 0.003933791055803296 0.10153319095603314 0.022535224603411445 0.012016791423556378 0.04816517275709468 5.204987275910746e-08 7.283580327826549 -1.061257842163331 down ALTLGALTLPLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALTLGALTLPLAR 13 0 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 0 9916600.0 1596100.0 4667000.0 3653500.0 False True 2186221.3029806674 4460796.508294825 2790618.546194406 1.0 2.0404139792312104 1.2764574850632509 21.06000801633253 -10.06346698332127 4.497113446909201 0.9999615936447045 1.6584357318713296 0.4975985741978691 0.31188393287624144 46327690.56212548 34556779.18773808 16386.721713897015 0.10676616815024041 8.640383455901252e-11 10.06346698332127 0.6584741382266251 ALTLIAGSPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALTLIAGSPLK 11 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 22984900.0 8733700.0 7445000.0 6806200.0 False True 11449965.277271118 6334235.020382711 6101959.713680516 1.0 0.5532099763618109 0.5329238618560075 23.44883988747832 ALTLIAGSPLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALTLIAGSPLK 11 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 11309600.0 4572900.0 1892800.0 4843900.0 False True 4427735.792578904 2648604.9108216045 3575137.27611487 1.0 0.5981849493505896 0.8074414200835944 22.078137706956653 -10.10715351295172 4.887617647084136 1.0000128569283828 0.7028131847153272 0.7289462189859851 0.08542859645134612 1.1968980123382045e-05 2.1864694807517553e-06 0.08271945990747848 0.027571960944625867 7.81351566247532e-11 10.10715351295172 -0.29719967221305565 ALTLIAGSPLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALTLIAGSPLK 11 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 22097100.0 4996800.0 10139000.0 6961300.0 False True 7580510.915011998 8329616.233631424 5585396.003753821 1.0 1.0988198984234614 0.7368099678733833 22.853863656469095 -6.833955278644212 1.3100063901239305 1.0526787299742204 0.7262483484275734 0.9135702714564329 0.04491675909532849 0.17598838407968154 0.5892303248192662 0.026908107556469094 0.0619315862751336 1.4656987631154475e-07 6.833955278644212 -0.32643038154664705 ALTLIAGSPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALTLIAGSPLK 11 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 23804000.0 8733700.0 6807700.0 8262600.0 False True 11962784.909367992 6506913.303946577 6311144.05358858 1.0 0.5439296412368869 0.5275647854076485 23.512049949001213 ALTLIAGSPLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALTLIAGSPLK 11 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 12967900.0 4572900.0 3482200.0 4912800.0 False True 3802568.963818915 3463440.697437419 5940043.765779286 1.0 0.910816011594196 1.5621133560753906 21.85854298239093 -6.872304599077982 1.1217679644119871 0.9487790112112386 1.6019759971874514 0.9669328107951416 0.05242773690233521 0.13466764231617231 0.3153090955789198 0.03621679084465488 0.08610908680349322 1.3418235225777932e-07 6.872304599077982 0.6531969859762128 ALTLIAGSPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALTLIAGSPLK 11 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 18121700.0 4996800.0 7703100.0 5421800.0 False True 6468456.101653385 7274415.713430894 4435088.032365886 1.0 1.1245984511777856 0.68564862506097 22.624989978561544 -6.83085929602179 1.3239794264714335 1.066540317916883 0.6736211926209206 0.9075935972858217 0.05614512532350916 0.17975694848666177 0.6159362739128983 0.033291903812679546 0.07661606303613612 1.4761847143897038e-07 6.83085929602179 -0.3929191252959625 ALTNLPHTDFTLCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALTNLPHTDFTLCK 14 0 Q9UBQ5-2;Q9UBQ5;K7ERF1;K7ES31;A0A087WVB9;K7EQM4 Q9UBQ5-2 EIF3K Eukaryotic translation initiation factor 3 subunit K 0 17663900.0 4481500.0 5244100.0 7938300.0 False True 5875289.898907741 4461700.721341702 7116920.865550536 1.0 0.7594009483976553 1.2113310131085826 22.486228608303612 -6.7620771157233746 1.6045236645047396 0.8606037603696379 1.2131592757620868 0.6993793133164398 0.10122980741009202 0.27947282873250934 1.4184958895428619 0.04976608286424966 0.11935785258079473 1.7295092307508067e-07 6.7620771157233746 0.3525555153924489 ALTNLPHTDFTLCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALTNLPHTDFTLCK 14 0 Q9UBQ5-2;Q9UBQ5;K7ERF1;K7ES31;A0A087WVB9;K7EQM4 Q9UBQ5-2 EIF3K Eukaryotic translation initiation factor 3 subunit K 0 13015300.0 4481500.0 4096100.0 4437700.0 False True 6138431.657983749 3915120.7580086594 3389606.657300375 1.0 0.6378047319165941 0.5521942486549956 22.549438669826504 -13.999999999999998 0.20262387467019377 3.0338054748779673 0.4980105265630588 0.9994872299184386 0.004395093297131959 12.583979365790407 0.14271902931913447 10.154497542740716 0.053464623528363606 1.0000000000000041e-14 13.999999999999998 -2.5357949483149085 ALTNLPHTDFTLCK(ub)CMIDQAHQEERPIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALTNLPHTDFTLCKCMIDQAHQEERPIR 28 2 Q9UBQ5-2;Q9UBQ5;K7ERF1;K7ES31;A0A087WVB9;K7EQM4 Q9UBQ5-2 EIF3K Eukaryotic translation initiation factor 3 subunit K 1 85263300.0 3271300.0 11349000.0 70643000.0 True False 4234762.3369633965 10717418.173427213 57786698.85839082 1.0 2.5308192811387635 13.645795031753233 22.01384957432308 -6.931946267398687 0.7306403679067756 0.8425843608874524 16.045009168343785 0.9969071176647628 0.313395854508873 0.09163976106293684 0.07282133493854202 0.28889816984852507 0.9951686582238793 1.1696440949816111e-07 6.931946267398687 15.202424807456334 ALTPAFLVCVGSSPFCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALTPAFLVCVGSSPFCK 17 0 O95801 O95801 TTC4 Tetratricopeptide repeat protein 4 0 8565600.0 1348800.0 5904600.0 1312200.0 False True 1768289.8617977793 5023656.695950538 1176426.1315112074 1.0 2.8409690088044175 0.665290321981014 20.75392335304768 -6.6823798017491205 1.8930433511143174 2.1622304263923073 0.6732948386047388 0.3353549051896141 0.7798292511768411 0.4331737297713372 3.003179664393766 0.3302741940616566 0.8685531615756018 2.077878733638871e-07 6.6823798017491205 -1.4889355877875685 ALTPAFLVCVGSSPFCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALTPAFLVCVGSSPFCK 17 0 O95801 O95801 TTC4 Tetratricopeptide repeat protein 4 0 60547000.0 14648000.0 22561000.0 23338000.0 False True 22222086.91224301 18534813.28010243 18725234.070591226 1.0 0.8340716762245622 0.8426406639726879 24.405490973133222 -9.7676692850325 5.608448370941586 1.0000000198196455 0.8383561700970987 0.9978967599601319 0.0034982746072244786 8.681166744023682e-10 1.8898891522423673e-10 0.0033871902743085854 0.0011290632733504027 1.707382064428746e-10 9.7676692850325 -0.16164384972254675 ALTPAFLVCVGSSPFCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALTPAFLVCVGSSPFCK 17 0 O95801 O95801 TTC4 Tetratricopeptide repeat protein 4 0 12507900.0 1348800.0 4449800.0 6709300.0 False True 1847487.8099494518 4253193.122479172 5124701.522370907 1.0 2.302149491636181 2.773875689340067 20.81713341457057 -9.847095127228522 0.2619666739631943 1.1881027782646417e-23 3.0171760631563953 0.999021416925055 0.023466955755171975 1.2666622791358966 0.11436028178467693 1.1683775834659744 0.19800756001300404 1.4220172764219287e-10 9.847095127228522 3.0171760631563953 ALTPAFLVCVGSSPFCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALTPAFLVCVGSSPFCK 17 0 O95801 O95801 TTC4 Tetratricopeptide repeat protein 4 0 50498000.0 14648000.0 15749000.0 20101000.0 False True 18962124.755247135 14872554.305516358 16442824.253677139 1.0 0.7843295251710057 0.867140389904203 24.17661729522567 -10.341098306040815 4.858051164175254 1.0001097064432096 0.8257349575375169 0.855167350909445 0.033807393959463417 4.019575112985821e-05 5.45181282527144e-06 0.032754425836421866 0.01091128948192998 4.559337000183887e-11 10.341098306040815 -0.1743747489056927 ALTPASLQK(ub)ELNNLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALTPASLQKELNNLLK 16 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5GY68;Q9UJX4-2 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 7641900.0 1705000.0 1418600.0 4518300.0 True False 1650875.7082698129 1985054.3779012728 3334821.6839054944 1.0 1.2024250935169998 2.020031954677271 20.654800075515524 -6.9446523519752805 0.6147694426243964 0.991010291385876 2.2743743545875184 0.998711858864343 0.015825950293236885 0.08570702504701573 0.04541758430127493 0.0160149210982852 0.06906021982155013 1.1359197432707898e-07 6.9446523519752805 1.2833640632016423 up ALTPASLQK(ub)ELNNLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALTPASLQKELNNLLK 16 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5GY68;Q9UJX4-2 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 10210800.0 1705000.0 2950900.0 5554900.0 True False 1417783.044306949 2935002.9159922083 6716403.907044329 1.0 2.070135432764269 4.737257885833647 20.4352053509498 -6.955527515002549 0.4944533143236236 0.9439197631736689 5.9774295342828605 0.9995666899873451 0.03271199871852584 0.08133919069856989 0.027342338485690617 0.03877509241209591 0.21998364239487397 1.107828375980963e-07 6.955527515002549 5.033509771109191 ALTQRPDYIK(ub)AVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALTQRPDYIKAVVK 14 2 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 12669400.0 4185600.0 3888900.0 4594900.0 True False 5487362.133408056 3308691.278813471 4119463.825393112 1.0 0.6029657234884424 0.7507184190219686 22.38768135760368 -10.159424868045281 6.181740796597821 1.0000020568206347 0.6768420712552038 0.8644654275101616 0.060319785362995613 1.7099104354514654e-06 2.3250851190592602e-07 0.05840475304046821 0.019468127013139797 6.927477628543868e-11 10.159424868045281 -0.3231599855654309 ALTQRPDYIK(ub)AVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALTQRPDYIKAVVK 14 2 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 17590600.0 3144600.0 6473400.0 7972600.0 True False 3044776.394267016 9058262.37833503 5884336.8871267745 1.0 2.9750172772590977 1.9326006659163355 21.5379048510757 -10.215503152024333 10.495662494396399 0.9999999915143021 2.4538089715877165 0.721712616027554 0.42556479953181575 8.414721078726571e-08 7.0200926167472855e-09 0.41205134532968796 0.13735044844323505 6.088311269682244e-11 10.215503152024333 1.4538089800734144 ALTQRPDYIK(ub)AVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALTQRPDYIKAVVK 14 2 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 34404000.0 7761100.0 5538900.0 21104000.0 True False 11774156.112411862 4550440.019376773 16932785.149788216 1.0 0.3864769564741778 1.4381315304574844 23.489120325657467 -6.748581428497601 1.6552679829127863 0.6386270109673643 1.4399764948354086 0.6427876003794839 0.2577892221052634 0.3025186458335852 1.6303976607254862 0.12305487417172084 0.29917001309383706 1.7840974459641272e-07 6.748581428497601 0.8013494838680443 ALTQRPDYIK(ub)AVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALTQRPDYIKAVVK 14 2 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 11722300.0 4185600.0 3423300.0 4113400.0 True False 5733129.431586911 3272047.2866607434 3141899.6381322183 1.0 0.5707262195465648 0.5480252409481275 22.45089141912657 ALTQRPDYIK(ub)AVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALTQRPDYIKAVVK 14 2 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 18125700.0 3144600.0 9675600.0 5305500.0 True False 2614874.229400375 9623475.622343762 6414855.520139646 1.0 3.68028240675673 2.4532176148336804 21.318310126509978 -9.001720911414445 12.860951028585525 1.0000000456999594 3.06675001140036 0.790904607867242 0.500947103591092 0.0 0.0 0.48503995461239324 0.1616799824615783 9.960452955524937e-10 9.001720911414445 2.0667499657004007 ALTSEIALLQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALTSEIALLQSR 12 0 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 20817900.0 7037000.0 7688600.0 6092300.0 False True 9225575.14640493 6541490.849928059 5461927.2374681635 1.0 0.7090604917436699 0.5920419215919125 23.13720742467075 -13.999999999637444 0.12551913345196386 2.3829431873614673 0.4184425661975505 0.9996663467696858 0.0031329913147505363 11.94600227444233 0.10970732365698009 4.093892916936097 0.15417771659517468 1.0000000008348165e-14 13.999999999637444 -1.9645006211639169 ALTSEIALLQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALTSEIALLQSR 12 0 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 11482100.0 4798600.0 1559300.0 5124200.0 False True 4646271.0696208365 2181936.6216420773 3782018.297295113 1.0 0.4696102721833094 0.8139900235316551 22.14764189466971 -10.156583297807563 5.377747389493742 1.0000104338222484 0.641800147857383 0.5905825847726719 0.14059244475870172 1.758810882970645e-05 2.758596642046745e-06 0.13613201269145597 0.045376016429366436 6.972952426253587e-11 10.156583297807563 -0.35821028596486537 ALTSEIALLQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALTSEIALLQSR 12 0 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 21257700.0 7037000.0 8527200.0 5693500.0 False True 9638769.067774532 8150440.108320463 4348812.561313214 1.0 0.8455893123915558 0.4511792460982052 23.20041748619364 -6.9549995393351525 0.5009607469048506 1.0078334525369506 0.2718960505272239 0.9995374614206404 0.00496989380857336 0.08153814156757618 0.0281185314352711 0.005817926682575654 0.03253636556857376 1.109175991786947e-07 6.9549995393351525 -0.7359374020097267 down ALTSEIALLQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALTSEIALLQSR 12 0 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 7433600.0 4798600.0 1238100.0 1396900.0 False True 3990248.514024239 1231430.1095563918 1688985.3314641519 1.0 0.3086098786149216 0.4232782307989081 21.928047170103987 -9.93121035853397 5.749378416935969 1.00000045420455 0.36594405471389624 0.9760575450994396 0.04681315875146141 2.725496699206895e-07 5.069139185014096e-08 0.04532667813679898 0.015108882018683665 1.1716277286095107e-10 9.93121035853397 -0.6340563994906537 ALTSELANAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALTSELANAR 10 0 P26038 P26038 MSN Moesin 0 9383800.0 2626600.0 1248300.0 5508900.0 False True 2543220.0207281513 1746752.6997985034 4065953.8265424953 1.0 0.6868272054961211 1.5987424577517948 21.278224848136485 -6.81400891654918 1.397691150995925 0.8301119148363315 1.6161883707001936 0.8700088672782025 0.13640188484894092 0.20139250272077666 0.7746264212385663 0.07672043919386515 0.17716372358167135 1.5345854757277058e-07 6.81400891654918 0.7860764558638621 ALTVPELTQQMFDAK(ub)NMMAACDPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALTVPELTQQMFDAKNMMAACDPR 24 1 A0A0B4J269;Q13509;Q13509-2;P04350;P68371 A0A0B4J269;P04350;P68371 TUBB3;TUBB4A;TUBB4B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta-4B chain 1 11021300.0 6543700.0 1432000.0 3045600.0 True False 6335973.8253402915 2003805.0677813475 2247865.993958473 1.0 0.3162584194662022 0.3547782954797395 22.5951349448096 -9.980600929205139 5.73512731024819 1.0000009464540514 0.3355183574726355 0.9974859616355096 0.015725673532593454 1.903105329844315e-07 3.3825115339476624e-08 0.015226339476478931 0.00507543930812946 1.0456806480447217e-10 9.980600929205139 -0.6644825889814159 ALTVPELTQQMFDAK(ub)NMMAACDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALTVPELTQQMFDAKNMMAACDPR 24 1 A0A0B4J269;Q13509;Q13509-2;P04350;P68371 A0A0B4J269;P04350;P68371 TUBB3;TUBB4A;TUBB4B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta-4B chain 1 106009000.0 13200000.0 19475000.0 73334000.0 True False 20025365.04926322 15999534.091130476 58839502.756566 1.0 0.7989634172346405 2.9382486966813546 24.255325206469063 -6.883887039261659 1.0579118182614338 0.8676509231255413 3.1016104493739682 0.976686790885978 0.1472787755173789 0.12424138614863628 0.25196713234563217 0.10684079087867218 0.2611121258876793 1.3065106696032217e-07 6.883887039261659 2.233959526248427 up ALTVPELTQQMFDAK(ub)NMMAACDPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALTVPELTQQMFDAKNMMAACDPR 24 1 A0A0B4J269;Q13509;Q13509-2;P04350;P68371 A0A0B4J269;P04350;P68371 TUBB3;TUBB4A;TUBB4B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta-4B chain 1 16120900.0 6543700.0 2271400.0 7305800.0 True False 5441376.4850624055 2259163.517362402 8833409.001797412 1.0 0.41518235754578414 1.6233776556440762 22.375540220243877 -6.775100881536642 1.5550096096602548 0.6667454124961074 1.6315068558737413 0.7496238505126651 0.24684919181091344 0.25827922712231915 1.2331771732740455 0.12507789536610406 0.29635649447533197 1.6784140968423348e-07 6.775100881536642 0.9647614433776339 ALTVPELTQQVFDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALTVPELTQQVFDAK 15 0 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 0 95133630.0 3148200.0 65190000.0 26795430.0 False True 4127320.68721217 55463906.1086297 24022895.943514165 1.0 13.438235192258157 5.820457813696229 21.976774107469563 -9.737963397070905 7.324354498478318 0.9999999977932659 9.629346502977253 0.631125985269721 3.109944591932852 2.580348050972136e-07 4.900936049633233e-08 3.0111909030456245 1.0037303010152152 1.8282542974061528e-10 9.737963397070905 8.629346505183987 ALTVPELTQQVFDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALTVPELTQQVFDAK 15 0 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 0 108132100.0 35562000.0 20734000.0 51836100.0 False True 34433103.77565461 29013194.326381586 38258670.36033315 1.0 0.8425959656560184 1.1111014159398362 25.037292894492758 -6.747826719817595 1.6577793013361715 0.9072012506945261 1.1115502356579428 0.6395477274534095 0.06613680935673831 0.3038835110182807 1.6424358525002636 0.03152351419294248 0.07670926691105917 1.787200511973213e-07 6.747826719817595 0.2043489849634167 ALTVPELTQQVFDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALTVPELTQQVFDAK 15 0 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 0 113720600.0 3148200.0 63592000.0 46980400.0 False True 4312174.616906042 60782295.16937747 35884597.11170974 1.0 14.095508779045774 8.321693878309757 22.039984168992454 -9.294887310963606 9.45307746856901 1.000055160543902 11.20860132867842 0.8065079440466509 2.3571500628977913 0.0 0.0 2.2823006664163312 0.760766911476813 5.071222773128354e-10 9.294887310963606 10.208546168134518 ALTVPELTQQVFDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALTVPELTQQVFDAK 15 0 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 0 41351400.0 35562000.0 3210800.0 2578600.0 False True 29571378.663720664 3193502.783106097 3117773.337900684 1.0 0.10799302999775294 0.10543212656248901 24.817698169927034 ALTVPELTQQVFDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALTVPELTQQVFDAK 15 0 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 0 10556600.0 3586300.0 3732600.0 3237700.0 False True 4642536.046541694 3524877.528780897 2648471.8216074044 1.0 0.7592569004190372 0.5704795385660597 22.14648168120055 -6.973854899488726 0.13787297211386806 1.2606958260094308 0.06412495013345396 0.9999989929984208 0.0001762980343687777 0.075070509944879 0.004167351475775483 0.010911461932409829 0.024825806028058707 1.0620503356092683e-07 6.973854899488726 -1.1965708758759768 ALTVPELTQQVFDAK(ub)NMMAACDPR ddPTM_RPMI8226_Bortezomib_2h_R1 2 ALTVPELTQQVFDAKNMMAACDPR 24 1 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 1 117323900.0 71210000.0 24357400.0 21756500.0 True False 68949477.52838324 34083436.84216298 16057819.968990514 1.0 0.49432480221670194 0.23289255473154627 26.0390362838251 -9.23539551457734 0.21209439692096105 1.4216953577234306 2.0595313218102483e-16 0.9994459850787347 0.00749475950410724 0.6627510632791911 0.0768199399381011 0.3230972451910047 0.13374363122420208 5.815733342160638e-10 9.23539551457734 -1.4216953577234304 ALTVPELTQQVFDAK(ub)NMMAACDPR ddPTM_RPMI8226_Bortezomib_8h_R1 2 ALTVPELTQQVFDAKNMMAACDPR 24 1 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 1 616683400.0 99454000.0 107749500.0 409479900.0 True False 150878989.0613198 88520759.87431405 328546018.283584 1.0 0.5867003777334279 2.1775465247189407 27.168816673727285 -6.837711492299113 1.2929837287885024 0.7800303153446647 2.2275451030653635 0.9204519500430253 0.19009069048940305 0.17148411090456972 0.5578820265580524 0.11532313513216863 0.2655412097747189 1.453076595472674e-07 6.837711492299113 1.4475147877206989 up ALTVPELTQQVFDAK(ub)NMMAACDPR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ALTVPELTQQVFDAKNMMAACDPR 24 1 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 1 139661500.0 71210000.0 20149500.0 48302000.0 True False 59214270.13788732 20040950.64413742 58401724.87678541 1.0 0.3384479889301976 0.9862778810038559 25.819441559259378 -9.921583518797394 11.258876833720771 0.9999861966235943 0.6623629349670166 0.2658792750791378 0.2644754460705298 0.0 0.0 0.25607724947373156 0.08535908315791049 1.197888736087876e-10 9.921583518797394 -0.33762326165657774 ALTVPELTQQVFDAK(ub)NMMAACDPR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ALTVPELTQQVFDAKNMMAACDPR 24 1 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 1 564808900.0 99454000.0 79524000.0 385830900.0 True False 128745163.53142716 75098419.4927857 315613635.1593495 1.0 0.5833106070384843 2.451460128692967 26.939942995819735 -6.8481577263548505 1.2438431569358595 0.7779275109469626 2.523570032585282 0.9375918132835986 0.20003250553281962 0.15949929530388238 0.4757782634610953 0.12589263095940223 0.2910192303562532 1.4185422442893752e-07 6.8481577263548505 1.7456425216383193 up ALVAIGTHDLDTLSGPFTYTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALVAIGTHDLDTLSGPFTYTAK 22 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 53884000.0 23815000.0 13034000.0 17035000.0 False True 23059005.860671956 18238544.17141205 12573022.46095435 1.0 0.7909510185137082 0.5452543156857484 24.458826979855377 -6.9689937469072145 0.2811818633437598 1.0533637059012857 0.2753425929815284 0.9999734350120104 0.0009578764055735507 0.07663057347059514 0.010193637301711066 0.004507635034337073 0.022518428494981486 1.0740048760509481e-07 6.9689937469072145 -0.7780211129197573 ALVAIGTHDLDTLSGPFTYTAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALVAIGTHDLDTLSGPFTYTAK 22 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 40619000.0 23815000.0 7440600.0 9363400.0 False True 19803227.683384206 7400516.010956542 11321243.648529926 1.0 0.3737025160381257 0.5716867891201876 24.239232255289654 -10.096053526245328 5.447154426623208 1.000006282408031 0.4726946525789398 0.904379898164241 0.08082674102530547 6.166847090692222e-06 1.0233622240267734e-06 0.0782610879197547 0.026086718493149776 8.015792636694248e-11 10.096053526245328 -0.5273116298290912 ALVAK(ub)EALVSQMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALVAKEALVSQMR 13 1 Q8TEQ0-2;Q8TEQ0;A0A0C4DGM3 Q8TEQ0-2 SNX29 Sorting nexin-29 1 8093200.0 1944500.0 2350300.0 3798400.0 True False 1882772.9118654865 3288787.0466525825 2803485.0904425634 1.0 1.7467783958045109 1.4890192400658762 20.8444275710382 -10.256214122433565 5.1680996849208025 0.9999114970381898 1.6178988179353517 0.8845539534735393 0.10522973468225777 0.00010732251515409457 1.544560746244824e-05 0.10190272973536925 0.033962750829104826 5.543523304001084e-11 10.256214122433565 0.6179873208971619 ALVAK(ub)EALVSQMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALVAKEALVSQMR 13 1 Q8TEQ0-2;Q8TEQ0;A0A0C4DGM3 Q8TEQ0-2 SNX29 Sorting nexin-29 1 5559600.0 1944500.0 2034300.0 1580800.0 True False 1616937.9059559326 2023340.822123064 1911337.971206625 1.0 1.2513410778918355 1.1820725855744245 20.624832846472476 -10.047380098640065 4.400883398468951 0.9999862835433966 1.2167068316060323 0.9288259180133693 0.028278743658231922 19581895.493676092 0.3475898954243448 2761.2877341442572 0.009680566111849913 8.966436999391069e-11 10.047380098640065 0.21672054806263574 ALVAVLLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALVAVLLSR 9 0 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 6728900.0 2324400.0 2657700.0 1746800.0 False True 3047310.909521619 2261181.5196334617 1566057.8924887795 1.0 0.7420252106761344 0.5139147067650628 21.539105271430007 -6.972575170188247 0.18669554422032522 1.1614379001300463 0.08829161382094691 0.9999961230023986 0.0003909401865580026 0.07547561100112775 0.005932982102496759 0.008284932277447431 0.025098796556711676 1.0651844794511557e-07 6.972575170188247 -1.0731462863090995 ALVAVLLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALVAVLLSR 9 0 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 14911000.0 3541600.0 5012000.0 6357400.0 False True 5372866.125641715 4117569.4410652686 5100857.10345259 1.0 0.7663636771842108 0.9493735716043666 22.35726046054639 -9.89062980392639 5.388382478953336 1.000000149616319 0.8578686245267916 0.44574081936379595 0.07471347653876924 1.3427413941678789e-07 2.7607449403536268e-08 0.07234108912667836 0.024113670863780926 1.2863827156010981e-10 9.89062980392639 -0.1421315250895273 ALVAVLLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALVAVLLSR 9 0 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 8933600.0 2324400.0 2563100.0 4046100.0 False True 3183793.494548122 2449853.766961747 3090494.5120452153 1.0 0.7694763404589017 0.97069565514765 21.602315332952898 -10.211159662977364 6.70347223974626 1.0000006694014343 0.8700859978780342 0.3572400470021678 0.08214744122999167 8.217930393907178e-07 9.671454198960032e-08 0.07953932803457033 0.026512972651442507 6.149507521337473e-11 10.211159662977364 -0.12991467152340008 ALVAVLLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALVAVLLSR 9 0 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 11608000.0 3541600.0 5423500.0 2642900.0 False True 4584671.015372969 5121677.457360337 2161919.3184440234 1.0 1.1171308563224533 0.47155386094113194 22.128386782638838 -6.859933353521789 1.1861086679094912 1.0635366389382517 0.4403371636272939 0.9535562636099487 0.06051922704596145 0.1468697415755417 0.3926686437586712 0.03979749580902251 0.09289000790148075 1.3805961135048606e-07 6.859933353521789 -0.6231994753109578 down ALVAYYQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALVAYYQK 8 0 P62249;M0R210;M0R3H0;M0R1M5;M0QX76 P62249 RPS16 40S ribosomal protein S16 0 43771000.0 11538000.0 14946000.0 17287000.0 False True 15126429.734150924 12716115.059051694 15498307.068613185 1.0 0.8406554145650468 1.0245846072733655 23.85056817505401 -6.677630115897998 1.9105640310339884 0.8989636483673494 1.023867188358692 0.3131428076315804 0.06756993433858385 0.44384276694206426 3.130358062927693 0.028401614071635172 0.07512848120712053 2.100728290409806e-07 6.677630115897998 0.12490353999134263 ALVAYYQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALVAYYQK 8 0 P62249;M0R210;M0R3H0;M0R1M5;M0QX76 P62249 RPS16 40S ribosomal protein S16 0 12477800.0 3889400.0 1717000.0 6871400.0 False True 3765933.1259499206 2402607.0540367113 5071574.202418648 1.0 0.6379845243350349 1.3466978920767192 21.84457595065788 -6.76784943251782 1.5826270363999997 0.791785296825367 1.350368563039455 0.7222684981967737 0.1524900054144634 0.26993204749702804 1.3339668339855804 0.07596124563484843 0.18118270136542947 1.7066739808263732e-07 6.76784943251782 0.558583266214088 ALVAYYQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALVAYYQK 8 0 P62249;M0R210;M0R3H0;M0R1M5;M0QX76 P62249 RPS16 40S ribosomal protein S16 0 24562500.0 11538000.0 6101800.0 6922700.0 False True 15803910.402725952 5832202.300045715 5287700.8374818675 1.0 0.3690353938630114 0.3345818030308381 23.913778236576903 -13.713580400829764 0.41654481938605015 9.999910113352083 0.33328543006834077 0.9998555434671078 0.003676416507284819 22.858406962978954 0.21443485316200733 185.39979503061187 0.008437336715573686 1.93383581493305e-14 13.713580400829764 -9.666624683283743 ALVAYYQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALVAYYQK 8 0 P62249;M0R210;M0R3H0;M0R1M5;M0QX76 P62249 RPS16 40S ribosomal protein S16 0 8828300.0 3889400.0 2629200.0 2309700.0 False True 3234208.429634869 2615035.9777446636 2792647.591153809 1.0 0.8085551796177503 0.8634717433684659 21.624981226092157 -10.050263350204228 5.471411265925239 1.000001043297958 0.8360134614929928 0.9224149676448626 0.022419593269784835 2.8530921618588166e-07 4.951359433752552e-08 0.02170781579718513 0.0072358926134929525 8.907106596408398e-11 10.050263350204228 -0.1639875818049652 ALVDHHDAEVKEK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALVDHHDAEVKEK 13 1 Q8N2F6-3;Q8N2F6;A0A0J9YWR7;H7C2M7;A0A0J9YXE4;Q8N2F6-6;Q8N2F6-4;Q8N2F6-5;Q8N2F6-2 Q8N2F6-3 ARMC10 Armadillo repeat-containing protein 10 1 9710180.0 682280.0 1495700.0 7532200.0 True False 883224.9097494547 1412462.980174031 6161416.886898515 1.0 1.599210987578131 6.976045194022358 19.752421335711897 -6.928024962069464 0.7628267437551716 0.9119645096258513 8.026351771024444 0.9961356954194508 0.16703699993892498 0.09367637059901514 0.08279904149587214 0.15042795316574173 0.4919001634559326 1.1802527959710363e-07 6.928024962069464 7.114387261398593 up ALVEQMEKEK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALVEQMEKEK 10 1 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 1 2558490.0 529070.0 1398000.0 631420.0 True False 439945.14677506086 1390468.696518726 763447.0026437797 1.0 3.160550142924198 1.735323160716947 18.74696413134848 -10.39552123085697 6.1370969304473855 0.9997175092472549 2.4479366518205703 0.5791534004858527 0.5818464790090818 0.002249341676006953 0.00022155246566523407 0.5634712843940833 0.18779014360429955 4.022339919655255e-11 10.39552123085697 1.4482191425733153 ALVFQPVAELK(ub)DQTDFEHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALVFQPVAELKDQTDFEHR 19 1 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 1 51658000.0 2626400.0 7188600.0 41843000.0 True False 3984440.815559459 5905738.165211842 33572712.70956158 1.0 1.4821999970860684 8.425953418220772 21.9259458370215 -6.920931216812807 0.8177899857467233 0.8518720585594631 9.570038845046225 0.9944356986156477 0.25307503125696595 0.09762704552993162 0.1027976541928492 0.21913183092891486 0.662363392376103 1.199689293864102e-07 6.920931216812807 8.718166786486762 up ALVFQPVAELK(ub)DQTDFEHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALVFQPVAELKDQTDFEHR 19 1 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 1 34752400.0 2626400.0 6919000.0 25207000.0 True False 3399926.5740839024 6533951.567710187 20619584.645661373 1.0 1.921791963836965 6.0647146920275015 21.69707215911395 -6.942208104239438 0.638690254346734 0.9546845555283047 7.2584529666746604 0.9984390603235096 0.08702374342286773 0.08677355602463138 0.05012947884710555 0.08620204495682406 0.35324983203486904 1.1423308241435464e-07 6.942208104239438 6.303768411146356 ALVILAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALVILAK 7 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 30438800.0 10293000.0 10948000.0 9197800.0 False True 13494222.677553795 9314601.074969748 8246099.887527652 1.0 0.6902658491373198 0.6110837270563322 23.68583853827177 -13.999999999999998 0.1915154278646974 2.6691463218512963 0.5551357756449499 0.9994886449946115 0.003794853390232285 12.375774398122115 0.13878071087788305 7.712658253909815 0.05380548470094072 1.0000000000000041e-14 13.999999999999998 -2.1140105462063463 ALVILAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALVILAK 7 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 46145700.0 24544400.0 3488500.0 18112800.0 False True 23765251.456925303 4881476.242287177 13368514.307647444 1.0 0.20540393823035658 0.5625235790952171 24.50235033089449 -10.637209749775966 6.527158900405198 1.0026400773529187 0.3839637586869049 0.7986940317901896 0.14579348287414803 0.0056163367187577916 0.00031216495627290155 0.14154551008717284 0.047054644263095975 2.305633375614507e-11 10.637209749775966 -0.6186763186660138 ALVILAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALVILAK 7 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 109527800.0 17461500.0 70523000.0 21543300.0 False True 26490372.10664464 57937619.651286 17285257.312236156 1.0 2.1871198871062054 0.6525109289763602 24.658964773401912 -6.70012607594143 1.830116378382959 1.737042478112746 0.6570153074512809 0.41833981868579206 0.5010838775897025 0.3952453004203278 2.573685636692904 0.2184093218318561 0.5616670324890661 1.9946831732216245e-07 6.70012607594143 -1.0800271706614653 ALVILAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALVILAK 7 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 79836100.0 10293000.0 21549100.0 47994000.0 False True 14098600.257866045 20596989.508655667 36658805.66745704 1.0 1.4609244273851916 2.6001734212588907 23.749048599794662 -6.955705525348189 0.49224022615377855 0.9755671662038824 3.134023897389602 0.9995762855071134 0.013843958694246546 0.08127239542053925 0.027082817614458257 0.016482546609857478 0.09396263451747225 1.1073743879376211e-07 6.955705525348189 2.1584567311857197 ALVILAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALVILAK 7 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 30811900.0 24544400.0 3961300.0 2306200.0 False True 20409756.101283003 3939959.690643513 2788415.757335981 1.0 0.1930429580388684 0.1366217089267762 24.282755606328767 -13.666794794503277 0.38083261335475266 9.999999999999936 0.13166531741205914 0.9998011419972799 0.005561356438940674 18.5832015710354 0.20082347207467802 135.74464317040545 0.015260218877657798 2.1537991711578908e-14 13.666794794503277 -9.868334682587877 ALVILAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALVILAK 7 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 69235300.0 17461500.0 31229600.0 20544200.0 False True 22604255.967623383 29491645.30697532 16805366.40129318 1.0 1.3046943615050595 0.7434602769214749 24.43009109549436 -6.7592679584205895 1.6151677932356001 1.17714579279351 0.7414803021873269 0.6879780788707817 0.12814249729872354 0.2841577611457947 1.4608580034712553 0.06260159273516828 0.1505539157734419 1.7407325151353258e-07 6.7592679584205895 -0.4356654906061832 ALVK(ub)ADPDVTLAGQEAIFILAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALVKADPDVTLAGQEAIFILAR 22 1 Q9NR33 Q9NR33 POLE4 DNA polymerase epsilon subunit 4 1 38006700.0 17360000.0 6937700.0 13709000.0 True False 26336389.186000705 5699613.230502493 10999410.141131848 1.0 0.21641589476252737 0.41765065299758947 24.650554224667726 -10.390966433587108 5.20362728771581 1.000462610898773 0.31703327388568375 0.9388674582071442 0.0821537460314738 0.0004411960968093287 5.163765177617298e-05 0.07959642605918678 0.026515007517356443 4.0647474418983426e-11 10.390966433587108 -0.6834293370130893 ALVMLLEVR ddPTM_RPMI8226_Bortezomib_8h_R1 2 ALVMLLEVR 9 0 Q92973-2;Q92973;Q92973-3;O14787-2;O14787;A0A075B780 Q92973-2;O14787-2 TNPO1;TNPO2 Transportin-1;Transportin-2 0 41001500.0 8797900.0 15239400.0 16964200.0 False True 13347057.51264492 12519810.004024342 13611218.434326995 1.0 0.9380202334606823 1.0197916972659937 23.670018385164173 -6.704038464780869 1.816682626510386 0.9616658423156796 1.0195660078638056 0.43667202280473427 0.026143651556175693 0.3871763402522521 2.4869973125184544 0.011469332183449938 0.029347595145703915 1.9767945507664443e-07 6.704038464780869 0.05790016554812594 ALVMLLEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALVMLLEVR 9 0 Q92973-2;Q92973;Q92973-3;O14787-2;O14787;A0A075B780 Q92973-2;O14787-2 TNPO1;TNPO2 Transportin-1;Transportin-2 0 21441400.0 6913100.0 6570800.0 7957500.0 False True 8949144.227573643 6205129.203802588 6509316.650845024 1.0 0.6933768241977444 0.7273674985356535 23.093318298889372 -9.878181319739204 6.616294859079611 1.0000000109535996 0.7103721615700017 0.9897756185292567 0.013876634690209591 2.249758645986138e-09 3.631251574901705e-10 0.013435994364762189 0.004478664588042277 1.3237887325428274e-10 9.878181319739204 -0.28962784938359787 ALVNCQYSSATFSTGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALVNCQYSSATFSTGER 17 0 Q9NPD3;E9PI41 Q9NPD3 EXOSC4 Exosome complex component RRP41 0 11463900.0 3748000.0 3803900.0 3912000.0 False True 4913664.295683629 3236372.947486067 3507223.766553759 1.0 0.6586475495139207 0.713769512018689 22.228367864652146 -10.468098926922819 6.088405280002617 1.0001812223804858 0.6862085307663183 0.9773800398765188 0.022503446959584953 5.5387804464739456e-05 4.838837682943546e-06 0.021801310829687358 0.007262956275561185 3.4033065774752655e-11 10.468098926922819 -0.3139726916141675 ALVNCQYSSATFSTGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALVNCQYSSATFSTGER 17 0 Q9NPD3;E9PI41 Q9NPD3 EXOSC4 Exosome complex component RRP41 0 10474400.0 3748000.0 3489900.0 3236500.0 False True 5133736.885891568 3335704.6784439893 2472105.3578098225 1.0 0.6497615192572695 0.4815411098694233 22.291577926175037 -13.999999999973069 0.09698654541445682 2.746062624345825 0.10590333682325319 0.9998087132234335 0.002986918522057554 12.104072596080705 0.09212148988673602 4.264127832130581 0.3356484904937231 1.0000000000620117e-14 13.999999999973069 -2.6401592875225717 ALVPLGIGIATGEQCHNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALVPLGIGIATGEQCHNR 18 0 Q7L5Y1;J3QL81;Q7L5Y1-2;Q7L5Y1-7;Q7L5Y1-6 Q7L5Y1 ENOSF1 Mitochondrial enolase superfamily member 1 0 5206800.0 1408900.0 1861300.0 1936600.0 False True 1847081.5438070085 1583601.295290575 1736219.2091789364 1.0 0.8573532124773571 0.9399797291030398 20.816816128253695 -10.195812165981632 4.58287048886321 1.0000209056877116 0.8986664707891497 0.667268227362592 0.03373213416299697 7.206699647643854e-06 1.2645836732658234e-06 0.0326677348658795 0.01088699948660587 6.370709969652421e-11 10.195812165981632 -0.10135443489856188 ALVPLGIGIATGEQCHNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALVPLGIGIATGEQCHNR 18 0 Q7L5Y1;J3QL81;Q7L5Y1-2;Q7L5Y1-7;Q7L5Y1-6 Q7L5Y1 ENOSF1 Mitochondrial enolase superfamily member 1 0 6593300.0 1408900.0 1384400.0 3800000.0 False True 1929808.4040908841 1323232.630401405 2902518.2634566138 1.0 0.6856808311106761 1.5040447835669803 20.880026189776586 -6.802575532902111 1.4452609916510448 0.8271387026903039 1.5160889563961917 0.8396207924439903 0.1349897640388655 0.21709859271974943 0.8949581170029456 0.07346798945589533 0.17060722386995164 1.5755219826585202e-07 6.802575532902111 0.6889502537058878 ALVQEK(ub)IQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALVQEKIQK 9 1 P42768;C9J3B7 P42768 WAS Wiskott-Aldrich syndrome protein 1 22657630.0 1191890.0 2512740.0 18953000.0 True False 1154054.1043575997 3516090.1857659966 13988640.722187731 1.0 3.04672906797833 12.121304078697818 20.13827943131334 -6.942518750919075 0.6357089157576779 0.9008899858943902 14.76101350792874 0.9984754332771087 0.18870760753519275 0.0866363971666321 0.049518250590009284 0.1874073342335615 0.7727820113081253 1.1415140180173619e-07 6.942518750919075 13.86012352203435 ALVQEK(ub)IQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALVQEKIQK 9 1 P42768;C9J3B7 P42768 WAS Wiskott-Aldrich syndrome protein 1 27025600.0 1306700.0 6922200.0 18796700.0 True False 1982359.4325660765 5686879.326604546 15081524.006113712 1.0 2.8687427886087904 7.6078655355609985 20.918787138592794 -6.955154795139149 0.49905945376150646 0.9043114135637118 9.776371303026604 0.9995461603703232 0.05924920428433799 0.0814795694595876 0.027889700168491127 0.06960754418422181 0.39092266593308056 1.1087795436618093e-07 6.955154795139149 8.872059889462893 ALVQEK(ub)IQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALVQEKIQK 9 1 P42768;C9J3B7 P42768 WAS Wiskott-Aldrich syndrome protein 1 11132090.0 1191890.0 3707200.0 6233000.0 True False 991109.3446797711 3687228.577778414 7536291.481864167 1.0 3.7203045229785046 7.603895092220278 19.918684706747616 -6.966066074857514 0.3392601430859506 0.5751423479186673 10.87797471270535 0.999933462414696 0.02210510016598955 0.07760106175934278 0.013594682963152112 0.05494713163016219 0.3363241700396811 1.0812694312274289e-07 6.966066074857514 10.302832364786683 ALVQEK(ub)IQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALVQEKIQK 9 1 P42768;C9J3B7 P42768 WAS Wiskott-Aldrich syndrome protein 1 16321400.0 1306700.0 3424400.0 11590300.0 True False 1691548.9089077956 3233829.1297104745 9480984.326520776 1.0 1.9117562091648317 5.604912915372035 20.689913460685244 -6.944585840988631 0.615422445771854 0.9594207836895804 6.751374763005399 0.9987049605962164 0.07164862816597525 0.08573540534266708 0.045540620568034304 0.07246009221716393 0.31202246337539524 1.1360937195277926e-07 6.944585840988631 5.791953979315818 ALVQNDTLLQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALVQNDTLLQVK 12 0 Q92522 Q92522 H1FX Histone H1x 0 6307800.0 2386000.0 1401700.0 2520100.0 False True 3128069.106056867 1192571.8237838075 2259344.226506165 1.0 0.38124855409192704 0.7222807904503793 21.576840954688187 -10.65351978609575 6.811771062271393 1.001955969992626 0.5517646722712272 0.6972770551806196 0.13922582748640622 0.004149786463190723 0.00021107856063320738 0.1352655799149108 0.044934942601399845 2.2206505101539343e-11 10.65351978609575 -0.45019129772139876 ALVQNDTLLQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALVQNDTLLQVK 12 0 Q92522 Q92522 H1FX Histone H1x 0 7138200.0 2386000.0 2774500.0 1977700.0 False True 3268168.6792255286 2651913.415955432 1510607.9920100395 1.0 0.8114371307737601 0.46221849001013454 21.64005101621108 -6.961520142338223 0.41345290182707123 1.0165683874591107 0.24405421852426407 0.9998224873353716 0.002968312338591864 0.07916250297652824 0.019157448446189166 0.0045020755039363106 0.029125396116477614 1.0926469496516311e-07 6.961520142338223 -0.7725141689348467 down ALVSEWK(ub)EPQAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALVSEWKEPQAK 12 1 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 1 36857900.0 2219300.0 7924600.0 26714000.0 True False 3366840.3525628666 6510393.214817601 21433966.190837864 1.0 1.9336804044961136 6.366196179905636 21.682963882997477 -6.940968200744522 0.650493321493623 0.9509581293093736 7.596339241621636 0.9982879929235049 0.0968547923225697 0.08732768267860465 0.05261883408338058 0.09498746359402055 0.37989973898315316 1.1455968195370388e-07 6.940968200744522 6.645381112312262 ALVSEWK(ub)EPQAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALVSEWKEPQAK 12 1 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 1 24461900.0 2219300.0 4989600.0 17253000.0 True False 2872927.598943196 4711924.373789092 14113131.030729387 1.0 1.640112467687097 4.912456212234827 21.454090205089926 -6.939311551798434 0.6659365642918759 0.9627970194252725 5.777316501919812 0.9980723424211659 0.07523216842284587 0.08808209904592028 0.0560502926883167 0.07285642849552362 0.28250911512746574 1.1499751301052378e-07 6.939311551798434 4.81451948249454 ALVWVSLSLLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALVWVSLSLLSK 12 0 Q99575 Q99575 POP1 Ribonucleases P/MRP protein subunit POP1 0 23216700.0 6140300.0 8247300.0 8829100.0 False True 9315284.016059913 6775504.878550985 7084024.515068005 1.0 0.7273535478757008 0.7604732719748395 23.151168325857125 -10.03201552341616 7.2320227826303265 1.0000000255800718 0.7439134100452472 0.9876106970203995 0.01352107074410839 5.5615359597617195e-09 7.552924783038534e-10 0.013091721624194613 0.004363906817901975 9.289331824112486e-11 10.03201552341616 -0.2560866155348246 ALVWVSLSLLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALVWVSLSLLSK 12 0 Q99575 Q99575 POP1 Ribonucleases P/MRP protein subunit POP1 0 13170400.0 6140300.0 2454000.0 4576100.0 False True 7948739.393408236 2317432.7427606303 3743296.7547511035 1.0 0.29154720365878906 0.47092961153756785 22.922294647949574 -10.746336885242734 10.414863611539923 1.0014114210979193 0.3812384076037006 0.9407037609902494 0.07323256135580285 0.00240275045286797 5.852095650641779e-05 0.07098751056448667 0.023635707544261437 1.7933419793314807e-11 10.746336885242734 -0.6201730134942187 ALWFQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALWFQGR 7 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4 P43243 MATR3 Matrin-3 0 8072800.0 1943700.0 2891800.0 3237300.0 False True 2548209.522817577 2460354.7121481136 2902335.250374358 1.0 0.9655229250645287 1.138970412121065 21.281052475294512 -6.85505217699627 1.2105015147587173 0.9814889716979536 1.1466086570635958 0.9473328279774452 0.017205275756104924 0.1519887606740986 0.426047296669612 0.01110587463528436 0.02579626693997248 1.3962006086821296e-07 6.85505217699627 0.16511968536564225 ALWFQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALWFQGR 7 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4 P43243 MATR3 Matrin-3 0 7403800.0 1943700.0 3417700.0 2042400.0 False True 2662338.4165174626 3266694.713177462 1560027.1845483643 1.0 1.22700205687996 0.5859612643042563 21.344262536817403 -6.810994864178414 1.4104611220521734 1.1235669271564144 0.5745004108062862 0.8623896226097246 0.09844909661345921 0.20544184469530213 0.8053528961843703 0.054882204500564746 0.1268907738619528 1.5452727133096962e-07 6.810994864178414 -0.5490665163501282 ALYDTFSAFGNILSCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALYDTFSAFGNILSCK 16 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEQ8;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 23267300.0 8901100.0 8977900.0 5388300.0 False True 11669428.298375024 7638432.315580101 4830770.404223314 1.0 0.654567826312773 0.4139680437383554 23.476230547338826 -8.031434539811185 0.16574569065385417 1.3217640179030519 2.6784134301376592e-12 0.9999215782742866 0.002129934451695692 0.10102856365053597 0.029033643720722185 0.09174597945346746 0.11164997965274494 9.301767075420465e-09 8.031434539811185 -1.3217640179003733 down ALYDTFSAFGNILSCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALYDTFSAFGNILSCK 16 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEQ8;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 68624800.0 48221000.0 10460000.0 9943800.0 False True 46690250.74984085 14636732.548179395 7339220.472394362 1.0 0.3134858415432538 0.1571895707246631 25.4766180008015 -13.999999999999947 0.20792965320652876 4.936960426753722 0.06326210699338712 0.9994889540309697 0.008275476585003607 12.69903886036073 0.1445449588961314 20.40486606519295 0.09394370550724125 1.0000000000001227e-14 13.999999999999947 -4.873698319760335 ALYDTFSAFGNILSCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALYDTFSAFGNILSCK 16 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEQ8;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 123490000.0 25098000.0 59442000.0 38950000.0 False True 38075500.90957638 48834110.67753426 31251515.42760851 1.0 1.2825599010110982 0.8207775257330477 25.182359680701076 -6.741089696464209 1.682479255581653 1.1679043309869028 0.8204285815148825 0.6099562278856583 0.11871707690792288 0.3158306269957175 1.755811648460039 0.05580871423255417 0.13679813661431203 1.8151407362495887e-07 6.741089696464209 -0.3474757494720203 ALYDTFSAFGNILSCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALYDTFSAFGNILSCK 16 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEQ8;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 41632300.0 8901100.0 6576200.0 26155000.0 False True 12192077.21318289 6285641.739414707 19977727.679133598 1.0 0.5155513395714267 1.6385827722229598 23.539440608861717 -6.789458028963621 1.4983704821522301 0.729052790050815 1.6503717160388605 0.7996121279464119 0.20587860374977293 0.23615401122141322 1.0474052616386271 0.10815187005188923 0.2533241885777 1.623835273397679e-07 6.789458028963621 0.9213189259880454 ALYDTFSAFGNILSCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALYDTFSAFGNILSCK 16 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEQ8;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 77672700.0 48221000.0 4810700.0 24641000.0 False True 40097898.052507564 4784783.804250816 29793319.17288866 1.0 0.11932754674534853 0.7430144875393413 25.257023276235778 -10.369278237669924 7.749775760581955 1.0000073625708485 0.4311710172705751 0.5258630578370826 0.2546191273637841 3.239029910273147e-05 2.6361600521281965e-06 0.24653709810741872 0.08217796999215012 4.2728904891404535e-11 10.369278237669924 -0.5688363453002734 ALYDTFSAFGNILSCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALYDTFSAFGNILSCK 16 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEQ8;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 77103000.0 25098000.0 28810000.0 23195000.0 False True 32489855.755542897 27206698.173974644 18973748.000798047 1.0 0.8373905497974725 0.5839899119146151 24.953486002793525 -6.964615364050652 0.36459358490523924 1.0207211028206267 0.39191325436441526 0.9999049944118705 0.001668478820361842 0.07809173968763469 0.015321662396336979 0.0033700492757054675 0.02158563207297295 1.0848873267188991e-07 6.964615364050652 -0.6288078484562114 ALYEQNQSDVNEAK(ub)SGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALYEQNQSDVNEAKSGGR 18 1 Q14691 Q14691 GINS1 DNA replication complex GINS protein PSF1 1 17004200.0 1577800.0 1807400.0 13619000.0 True False 2068511.079436933 1537742.9651900202 12209836.522672711 1.0 0.7434057184787269 5.902717487979971 20.98016125433542 -6.895199825367102 0.9911275867770817 0.7563408300297428 6.3944221191471735 0.9840226755947833 0.3000713819911298 0.11502498716802759 0.1980203440934143 0.22896524724137682 0.582595522493098 1.2729172580425353e-07 6.895199825367102 5.638081289117431 up ALYEQNQSDVNEAK(ub)SGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALYEQNQSDVNEAKSGGR 18 1 Q14691 Q14691 GINS1 DNA replication complex GINS protein PSF1 1 21379800.0 2344200.0 2898600.0 16137000.0 True False 2269784.6541502057 4056026.0959993117 11910235.600376884 1.0 1.7869651592643552 5.247297614158911 21.11412399762146 -6.942706827164521 0.6338804618062832 0.9622312332748796 6.259769355095286 0.9984973937648747 0.07151453906544901 0.08655315937994577 0.04914693343836066 0.07113483491929219 0.29445640487438124 1.1410197792026131e-07 6.942706827164521 5.2975381218204065 ALYEQNQSDVNEAK(ub)SGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALYEQNQSDVNEAKSGGR 18 1 Q14691 Q14691 GINS1 DNA replication complex GINS protein PSF1 1 102874600.0 6843600.0 14949000.0 81082000.0 True False 10382241.534177098 12281234.152929883 65056107.160496935 1.0 1.1829077673160973 6.266094556396132 23.307614620539386 -6.914521526655034 0.8643643871251769 0.8642154516229791 6.990767619099162 0.9925191703941288 0.21108248860128445 0.1015037184763314 0.12310637378996918 0.1767765555845798 0.504722309275771 1.2175266422613034e-07 6.914521526655034 6.126552167476183 up ALYEQNQSDVNEAK(ub)SGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALYEQNQSDVNEAKSGGR 18 1 Q14691 Q14691 GINS1 DNA replication complex GINS protein PSF1 1 16066900.0 1577800.0 1913100.0 12576000.0 True False 2161155.2984417584 1828572.916224303 9605807.810850095 1.0 0.8461089851075234 4.444755921879422 21.043371315858312 -6.896911014803149 0.9806052735322803 0.8374383795361501 4.799647479082913 0.9849653458673924 0.20370597055967818 0.11371434248763085 0.1905272915533485 0.15666507322313414 0.40164496286941953 1.2679116292503734e-07 6.896911014803149 3.962209099546763 up ALYEQNQSDVNEAK(ub)SGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALYEQNQSDVNEAKSGGR 18 1 Q14691 Q14691 GINS1 DNA replication complex GINS protein PSF1 1 24336400.0 2344200.0 5596200.0 16396000.0 True False 1949306.165668243 5566052.159841277 19824327.793461423 1.0 2.8554017105533416 10.169940537106664 20.894529273055735 -6.94520860006538 0.6091815637042916 0.9189960848505275 12.486729763734566 0.9987695943950093 0.13885546092309847 0.08546870496664355 0.04437819884798622 0.14125295949774352 0.6166038327917933 1.1344657788636254e-07 6.94520860006538 11.567733678884037 ALYEQNQSDVNEAK(ub)SGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALYEQNQSDVNEAKSGGR 18 1 Q14691 Q14691 GINS1 DNA replication complex GINS protein PSF1 1 117360600.0 6843600.0 16172000.0 94345000.0 True False 8859175.107523838 15272013.983669475 77175178.06144816 1.0 1.723864106794706 8.711327761870916 23.078740942631836 -6.926779026618452 0.7727769757951927 0.8800944724644321 10.034825643200302 0.995866408833968 0.2235544418245108 0.09434503955671467 0.08612981588411245 0.19989424405444026 0.6438047796885216 1.18364365227944e-07 6.926779026618452 9.15473117073587 up ALYIVHPTMFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALYIVHPTMFIK 12 0 Q07960;H0YE29;E9PNR6 Q07960 ARHGAP1 Rho GTPase-activating protein 1 0 14763400.0 5557900.0 2584400.0 6621100.0 False True 5381467.506740652 3616364.3974679615 4886835.281257701 1.0 0.6720033880978042 0.9080859960850102 22.359568213481424 -9.869710261875527 6.070157751305337 1.0000000289127795 0.7900446920912996 0.5132738529891101 0.0963803211194105 3.768891383149844e-08 7.10159581004866e-09 0.09331985716438344 0.031106614883077113 1.3498631389768354e-10 9.869710261875527 -0.20995533682147993 ALYK(ub)AISVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALYKAISVPR 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 9701820.0 2384220.0 3525500.0 3792100.0 True False 3125735.508819327 2999509.142291369 3399729.86839174 1.0 0.9596170673520494 1.0876575637315864 21.575764275922023 -6.821898747459072 1.363529365696217 0.9782746672381478 1.0905709699864277 0.8887248125245937 0.017828732599032858 0.1910195794349593 0.6973013663402129 0.010273398715569381 0.023668669878230422 1.5069583614116739e-07 6.821898747459072 0.11229630274827984 ALYK(ub)AISVPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALYKAISVPR 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 12552600.0 1899500.0 4320500.0 6332600.0 True False 1839201.4122337303 6045698.181109859 4673902.08607218 1.0 3.2871321981899153 2.541267125494252 20.810648048269012 -10.084680558734735 5.521136476831349 0.9999830806499338 2.9141996618427695 0.8977712547948249 0.3044981408471255 6.341643438081808e-05 1.0513277658426684e-05 0.29483164834500986 0.09827635237065258 8.228476653571215e-11 10.084680558734735 1.9142165811928358 ALYK(ub)AISVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALYKAISVPR 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 9843220.0 2384220.0 3605300.0 3853700.0 True False 3265730.565122842 3446005.9248672193 2943535.4294428276 1.0 1.055202153438398 0.9013405640009085 21.638974337444914 -6.809684070255312 1.4159110333574039 1.0300961888525912 0.8986696520330837 0.8589802975783606 0.023899747647372818 0.20723788845365265 0.8189266428808647 0.013272702069695776 0.030706191372958363 1.5499437234019682e-07 6.809684070255312 -0.13142653681950756 ALYK(ub)AISVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALYKAISVPR 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 13578400.0 1899500.0 7278100.0 4400800.0 True False 1579518.412117918 7238891.430710255 5320986.932999816 1.0 4.582973756541333 3.3687400489780304 20.59105332370329 -9.734958893454328 8.66539434541495 0.9999999997676063 3.975856902759682 0.8889953356862546 0.49570883533631743 0.0 0.0 0.4799680159563575 0.15998933865211915 1.8409462412132851e-10 9.734958893454328 2.9758569029920756 ALYLIATNGTPELQNPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALYLIATNGTPELQNPEK 18 0 Q13177;H0YCG5;E9PM17;B3KNX7;Q13153;Q13153-2 Q13177 PAK2;PAK1 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34;Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase PAK 1 0 20446100.0 4738800.0 7658100.0 8049200.0 False True 6212612.690604477 6515541.331040003 7216345.99737845 1.0 1.0487602648872114 1.1615637988010985 22.5667686852871 -6.9571013876808685 0.47452328682019906 0.9971478196193435 1.217836032717434 0.9996471239712633 0.0012710441320279166 0.08075327493476414 0.02508391043508049 0.00157325867734966 0.009307633635982727 1.103820898678237e-07 6.9571013876808685 0.2206882130980905 ALYLIATNGTPELQNPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALYLIATNGTPELQNPEK 18 0 Q13177;H0YCG5;E9PM17;B3KNX7;Q13153;Q13153-2 Q13177 PAK2;PAK1 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34;Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase PAK 1 0 18706800.0 5719700.0 3497500.0 9489600.0 False True 5538131.254305483 4894069.989221552 7003989.078102294 1.0 0.883704225214377 1.264684558109239 22.400967815461605 -6.8247840256534955 1.351007741364626 0.9376016854969215 1.2738895904761132 0.8950435371982471 0.05164682239245695 0.18733662786022579 0.6705219467100936 0.030029927335546474 0.06914335064897503 1.496979918100052e-07 6.8247840256534955 0.3362879049791917 ALYLIATNGTPELQNPEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALYLIATNGTPELQNPEK 18 0 Q13177;H0YCG5;E9PM17;B3KNX7;Q13153;Q13153-2 Q13177 PAK2;PAK1 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34;Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase PAK 1 0 45229000.0 7567400.0 28450000.0 9211600.0 False True 11480299.051045034 23372875.219135433 7390923.222412287 1.0 2.0359117053669293 0.6437918724547078 23.45265688757011 -6.707453433438543 1.8041741008777625 1.638506685998835 0.6472925311305125 0.4530231263880081 0.4367061879013921 0.38023215905004065 2.410988609856908 0.19273568267290397 0.4911770665860556 1.961311462823248e-07 6.707453433438543 -0.9912141548683225 ALYLIATNGTPELQNPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALYLIATNGTPELQNPEK 18 0 Q13177;H0YCG5;E9PM17;B3KNX7;Q13153;Q13153-2 Q13177 PAK2;PAK1 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34;Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase PAK 1 0 22564900.0 4738800.0 7563100.0 10263000.0 False True 6490862.421254792 7228937.234172826 7839090.7731198035 1.0 1.1137098223652306 1.207711743735338 22.629978746809993 -6.9733081591980115 0.16057148430679202 0.9056037284875033 1.4183132809408 0.9999980281807083 0.00011911324436908917 0.0752431704388982 0.0049595445566890314 0.0043271706336247915 0.011256618369058355 1.0633882097743172e-07 6.9733081591980115 0.5127095524532966 ALYLIATNGTPELQNPEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALYLIATNGTPELQNPEK 18 0 Q13177;H0YCG5;E9PM17;B3KNX7;Q13153;Q13153-2 Q13177 PAK2;PAK1 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34;Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase PAK 1 0 13582000.0 5719700.0 3507500.0 4354800.0 False True 4756183.975672995 3488604.4013157585 5265368.54567979 1.0 0.7334881113008512 1.1070573746960126 22.18137309089588 -6.715131247843742 1.7766589137749045 0.837023379256276 1.1063295486349463 0.48955225137578284 0.11222090800436688 0.36485183728063747 2.247918704487835 0.05020435783389962 0.12676753619812411 1.926942485193295e-07 6.715131247843742 0.26930616937867025 ALYNQYIHFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALYNQYIHFK 10 0 H3BQK9;Q9UPN3-4;Q9UPN3-2;Q9UPN3;A0A590UJG2;H3BPE1;Q9UPN3-3;E9PLY5;A0A5F9ZGX0;E9PLY0;E9PNZ4 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 0 3865350.0 1590100.0 767150.0 1508100.0 False True 2178002.94083676 733254.7763741973 1151917.8402944524 1.0 0.33666381372859416 0.528887183160506 21.05457447137153 -10.39287623022703 5.268155043003719 1.0003591971090908 0.43277549844459007 0.9206985494067511 0.07847486195783898 0.00033127624345709333 3.817768706171105e-05 0.07602961360170313 0.025327652788211422 4.046912083877826e-11 10.39287623022703 -0.5675836986645008 ALYYLQIHPQELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ALYYLQIHPQELR 13 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 65288300.0 20914800.0 23192200.0 21181300.0 False True 27419505.33921131 19732014.16248753 18989662.26137655 1.0 0.7196342136147047 0.692560351707744 24.70869920866551 -13.999999999999998 0.3305545734614714 4.062185593875664 0.6877966634648686 0.9997159906229122 0.002342286355136057 18.870287365931045 0.1838809551399539 40.184444208917505 0.008657962154801269 1.0000000000000041e-14 13.999999999999998 -3.3743889304107952 ALYYLQIHPQELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ALYYLQIHPQELR 13 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 81461500.0 32333800.0 15147600.0 33980100.0 False True 31307381.217627306 21196115.673690464 25079692.4288509 1.0 0.6770325351184661 0.8010792168950251 24.89999949998444 -10.259279626695376 6.022931736544383 1.0000090206766448 0.7390558760067448 0.8550757337472519 0.050641845772997705 6.134409933489573e-06 7.544370265818804e-07 0.04903545072353439 0.016344585441668336 5.5045316516259425e-11 10.259279626695376 -0.26095314466989994 ALYYLQIHPQELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ALYYLQIHPQELR 13 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 84111300.0 22500900.0 30803400.0 30807000.0 False True 34135510.33613379 25306292.601937275 24717982.94681221 1.0 0.7413480083568448 0.7241134731373048 25.024769984975155 -13.999999999999995 0.38486452835249657 4.957899339710813 0.7227265398662062 0.9998152406053126 0.0017152194960944754 24.66294986166858 0.20281901505648556 81.03686203972414 0.004604509677773367 1.0000000000000123e-14 13.999999999999995 -4.235172799844607 ALYYLQIHPQELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ALYYLQIHPQELR 13 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 73519000.0 20914800.0 21044100.0 31560100.0 False True 28647566.76121798 20114302.07846737 24106254.380662356 1.0 0.702129512294125 0.8414765058963581 24.771909270188402 -10.144518227868405 5.239114249880316 1.0000075221702482 0.7718030090950865 0.7814550994319461 0.05688817191993239 4.998517341397186e-06 8.161961411875408e-07 0.05508355117391774 0.018360578536762144 7.169382841758731e-11 10.144518227868405 -0.22820451307516176 ALYYLQIHPQELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ALYYLQIHPQELR 13 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 64792400.0 32333800.0 16230000.0 16228600.0 False True 26886987.330212373 16142565.76859725 19621925.22743155 1.0 0.6003858137894895 0.7297926311507122 24.680404775418715 -10.880376098702662 10.890824063495149 1.0166773199493886 0.6650892224701013 0.8993015728625557 0.052830111962088526 0.01911695525076422 0.00020997865283527246 0.04571042201726898 0.017050845317286848 1.3171156233618719e-11 10.880376098702662 -0.3515880974792873 ALYYLQIHPQELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ALYYLQIHPQELR 13 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 93445000.0 22500900.0 41313700.0 29630400.0 False True 29127858.6090483 39014556.27733892 24237971.233578175 1.0 1.3394241163069711 0.8321233482659406 24.795896307067604 -6.726391263661542 1.7363585666634322 1.2050792507685115 0.8326165744914185 0.5424813466064059 0.14273070290165427 0.3430398134667171 2.0244528293543547 0.06518634457813911 0.1624223859077768 1.877624469138765e-07 6.726391263661542 -0.37246267627709306 AMAK(ub)AGLSNYGNPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AMAKAGLSNYGNPR 14 1 U3KQL4;U3KPU7;U3KQS2;O43826;O43826-2 U3KQL4 SLC37A4 Glucose-6-phosphate translocase 1 15516490.0 703190.0 1319300.0 13494000.0 True False 921888.899701646 1122465.5825911227 12097770.323588029 1.0 1.2175714263989836 13.122807235777838 19.81423337096204 -6.910859998900667 0.8898480806776349 0.6413405797404091 14.690052477431923 0.9912423120727383 0.5300664139028668 0.10385229263892157 0.1356991603860622 0.43582623280855837 1.2103837340054366 1.2278349777079847e-07 6.910859998900667 14.048711897691513 up AMAK(ub)AGLSNYGNPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AMAKAGLSNYGNPR 14 1 U3KQL4;U3KPU7;U3KQS2;O43826;O43826-2 U3KQL4 SLC37A4 Glucose-6-phosphate translocase 1 23897740.0 980440.0 1902300.0 21015000.0 True False 949316.4688657228 2661898.310363447 15510541.063513696 1.0 2.8040157288580256 16.338641087777866 19.856529585869513 -6.931311101189852 0.7359507565843906 0.8038660400725137 19.212333121262873 0.996789710316122 0.387846705389573 0.09196272299722645 0.07438684142800114 0.3561435593563858 1.2159408318506844 1.1713559793584786e-07 6.931311101189852 18.40846708119036 AMAK(ub)AGLSNYGNPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AMAKAGLSNYGNPR 14 1 U3KQL4;U3KPU7;U3KQS2;O43826;O43826-2 U3KQL4 SLC37A4 Glucose-6-phosphate translocase 1 19364990.0 703190.0 1423800.0 17238000.0 True False 963178.3459952214 1360891.8081230281 13166739.427753977 1.0 1.412917777669578 13.670094933611912 19.87744343248493 -6.914059955733586 0.8676476868749614 0.6674673914778253 15.399694380331635 0.9923652102939773 0.5135890084905279 0.1017938021119291 0.12466364594337989 0.42911240244509435 1.2206415400938821 1.218821325151938e-07 6.914059955733586 14.73222698885381 up AMAK(ub)AGLSNYGNPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AMAKAGLSNYGNPR 14 1 U3KQL4;U3KPU7;U3KQS2;O43826;O43826-2 U3KQL4 SLC37A4 Glucose-6-phosphate translocase 1 20043240.0 980440.0 3662800.0 15400000.0 True False 815279.3008564849 3643067.769391121 18620068.798445113 1.0 4.468490449302376 22.838883286849004 19.63693486130379 -6.9385293653052456 0.6731071184168427 0.7876125412815054 27.585561094930238 0.9979648427378625 0.43229779884998915 0.08844406539396175 0.057713519470245056 0.4162600513610673 1.5916215379093648 1.152048160172343e-07 6.9385293653052456 26.797948553648734 AMAQQVFMLDTQCSPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AMAQQVFMLDTQCSPK 16 0 Q5TH69 Q5TH69 ARFGEF3 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 0 47542000.0 11545000.0 23356000.0 12641000.0 False True 15135606.801939053 19871375.84097496 11333030.581034247 1.0 1.3128892750060868 0.7487661862081637 23.85144317965444 -6.756178151157748 1.6271051017702909 1.1826073899948768 0.7471031031791191 0.6750728963306619 0.13153887670471406 0.2893868961092963 1.5091088358801859 0.06381653617716501 0.1539303478322508 1.7531611932210915e-07 6.756178151157748 -0.4355042868157577 AMAQQVFMLDTQCSPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AMAQQVFMLDTQCSPK 16 0 Q5TH69 Q5TH69 ARFGEF3 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 0 59970000.0 19025000.0 23547000.0 17398000.0 False True 18421061.788758475 32949439.89598281 12840941.87118779 1.0 1.7886829909061124 0.697079355057808 24.13485288488226 -6.7128890119444025 1.7851757215743378 1.4834289147484845 0.6994472761281909 0.4787334017928436 0.33219992209097376 0.3692754638775027 2.2958165110259134 0.14799838805702648 0.3746363485310928 1.9369168981036632e-07 6.7128890119444025 -0.7839816386202936 AMAQQVFMLDTQCSPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AMAQQVFMLDTQCSPK 16 0 Q5TH69 Q5TH69 ARFGEF3 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 0 125509000.0 40917000.0 55443000.0 29149000.0 False True 62074080.43338651 45548763.4718638 23387687.373539414 1.0 0.733780720614033 0.3767705813803785 25.887487648660056 -6.9670519683156025 0.32089136279681607 1.0483838683428006 0.050637166058586515 0.9999494078169124 0.0018161116101473602 0.0772713879868751 0.012440326265299527 0.0053921668317028545 0.031378764949744675 1.0788176216046138e-07 6.9670519683156025 -0.9977467022842141 down AMAQQVFMLDTQCSPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AMAQQVFMLDTQCSPK 16 0 Q5TH69 Q5TH69 ARFGEF3 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 0 44005000.0 11545000.0 14633000.0 17827000.0 False True 15813498.491893873 13986465.675139962 13616629.758589758 1.0 0.8844637182790094 0.8610763624235176 23.91465324117733 -13.99999999999981 0.22455359769681418 1.7114406697923399 0.8490994877599413 0.9995028507149537 0.0013541195799676514 13.127446597842631 0.15008212772575472 4.151532844228355 0.012565162497771095 1.0000000000004377e-14 13.99999999999981 -0.8623411820323986 AMAQQVFMLDTQCSPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AMAQQVFMLDTQCSPK 16 0 Q5TH69 Q5TH69 ARFGEF3 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 0 49902100.0 19025000.0 22372000.0 8505100.0 False True 15820130.450404525 22251477.595505707 10283477.086860735 1.0 1.4065293371166059 0.6500247971468391 23.915258160316537 -6.760768198686172 1.609859159781218 1.235912820159016 0.6471823643948228 0.6939891363431565 0.17100486974903392 0.28162847567000576 1.4387442970987998 0.08380905530732638 0.20123130565624334 1.7347296492082062e-07 6.760768198686172 -0.5887304557641931 AMAQQVFMLDTQCSPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AMAQQVFMLDTQCSPK 16 0 Q5TH69 Q5TH69 ARFGEF3 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 0 97385000.0 40917000.0 36953000.0 19515000.0 False True 52967863.09465085 34896533.06570232 15963470.240809377 1.0 0.6588246349176671 0.30138029567633257 25.658613970752505 -7.336507418274465 0.2995162849852136 1.079361521839908 9.850805761842536e-15 0.9998403370159998 0.0036041762330836376 0.10916855515456211 0.022641574797745537 0.014936268712221671 0.051967854030785444 4.6077889796276144e-08 7.336507418274465 -1.0793615218398982 down AMDQEITVNPQFVQK(ub)SMGSQEDDSGNKPSSYS ddPTM_RPMI8226_Bortezomib_1h_R1 1 AMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS 32 2 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 10400400.0 3078300.0 5184500.0 2137600.0 True False 4035681.1102996096 4410992.809022716 1916421.6573070835 1.0 1.0929983535530743 0.4748694470472688 21.944380750020848 -6.868585020434175 1.1416109770273477 1.052168144457536 0.4396377477291526 0.9632475092865346 0.052169935224625714 0.138215808460652 0.3375592989455946 0.03549642001689455 0.08383551433258511 1.3533651207984272e-07 6.868585020434175 -0.6125303967283833 down AMDQEITVNPQFVQK(ub)SMGSQEDDSGNKPSSYS ddPTM_RPMI8226_Bortezomib_2h_R1 2 AMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS 32 2 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 83357900.0 32354700.0 30151200.0 20852000.0 True False 31327617.758567385 42190731.396430895 15390235.653408892 1.0 1.3467583689759717 0.49126734665932315 24.90093173144455 -6.796711176569734 1.4697008199081736 1.1921277553146488 0.4804468601682861 0.8222531498352714 0.14812219869563265 0.22549110790875826 0.9619547563918601 0.07930620842674604 0.18478635572846344 1.596940824532791e-07 6.796711176569734 -0.7116808951463627 down AMDQEITVNPQFVQK(ub)SMGSQEDDSGNKPSSYS ddPTM_RPMI8226_Bortezomib_8h_R1 2 AMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS 32 2 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 145242200.0 63215000.0 52271400.0 29755800.0 True False 95901776.63554335 42943160.2716877 23874553.087569524 1.0 0.4477827395720217 0.24894797495045654 26.515054206457506 -13.999999999999998 0.142173954757687 3.643353161657958 0.00920711352371725 0.999594410755276 0.006398794844284157 11.936857581033955 0.11829044065175923 8.743732797213077 0.21465388594971857 1.0000000000000041e-14 13.999999999999998 -3.634146048134241 AMDQEITVNPQFVQK(ub)SMGSQEDDSGNKPSSYS ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS 32 2 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 35050900.0 10839000.0 16619000.0 7592900.0 True False 14846471.212961229 15884717.628316203 5799613.40068414 1.0 1.0699322014276744 0.39063918405209824 23.82361672866945 -6.881509642953276 1.0713807851127857 1.044267742141849 0.3410896286314212 0.9748813335999401 0.048351322673426 0.12629956528540523 0.26429663293213645 0.034716965758243644 0.08428330150853551 1.3136823260010877e-07 6.881509642953276 -0.7031781135104277 down AMDQEITVNPQFVQK(ub)SMGSQEDDSGNKPSSYS ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS 32 2 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 65888500.0 25310000.0 34913000.0 5665500.0 True False 21046386.423113734 34724916.73931211 6850129.855687707 1.0 1.6499229863600828 0.3254777194513877 24.327069214036314 -6.773252904823274 1.5618134845199687 1.3712231713257936 0.3170601968525126 0.7429187423340614 0.2741691378765914 0.26119858732705137 1.257794320752518 0.13832752396553122 0.32832970352066027 1.685571172653096e-07 6.773252904823274 -1.054162974473281 AMDQEITVNPQFVQK(ub)SMGSQEDDSGNKPSSYS ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AMDQEITVNPQFVQKSMGSQEDDSGNKPSSYS 32 2 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 112652000.0 46611000.0 48411000.0 17630000.0 True False 60338858.3401709 45716885.293310866 14421520.899076074 1.0 0.75766904696098 0.23900884597073782 25.846584064001494 -7.032837399816037 0.47543474726134505 1.013067704500014 2.0803992229016377e-12 0.999676242078497 0.0057115517306919415 0.07376565411254773 0.02459837600491415 0.007225374230276252 0.03914468124979949 9.271768941370691e-08 7.032837399816037 -1.0130677044979337 down AMEALATAEQACK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AMEALATAEQACK 13 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 6341700.0 1522300.0 2272000.0 2547400.0 False True 1995750.0419741727 1933026.456186637 2283819.4843862546 1.0 0.9685714220376564 1.1443414437446922 20.928499610747906 -6.8606738764996305 1.182407169831341 0.9829183888765829 1.152960053092856 0.954450092800767 0.01633424562166312 0.14610396053833216 0.38777425325508114 0.010772061421705444 0.025163205819471592 1.3782440412164612e-07 6.8606738764996305 0.1700416642162732 AMEALATAEQACK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AMEALATAEQACK 13 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 6595000.0 1522300.0 2461700.0 2611000.0 False True 2085135.4486106578 2352933.9542467045 1994335.5752329505 1.0 1.1284321868943732 0.9564537289708407 20.991709672270797 -6.706724075802792 1.8063335771796765 1.0792147294052348 0.956884966198795 0.4498681543718698 0.05414851601870823 0.3816535434305872 2.4252294456677417 0.023871372876241057 0.060899111179798626 1.9646080724242164e-07 6.706724075802792 -0.12232976320643973 AMEAVAAQGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AMEAVAAQGK 10 0 P18669;P15259 P18669 PGAM1;PGAM2 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2 0 14461880.0 788080.0 7451300.0 6222500.0 False True 1033180.511777577 6339595.0849399045 5578655.390434754 1.0 6.135999481864687 5.3994973064646095 19.978660905516605 -10.216684395502089 5.4012741473082695 0.9997198368546282 5.767748394165238 0.982417574044943 0.30067575403206964 0.0010144429752492069 0.0001471178161972016 0.2911415486731468 0.09704268233091387 6.071774088964933e-11 10.216684395502089 4.76802855731061 AMEAVAAQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AMEAVAAQGK 10 0 P18669;P15259 P18669 PGAM1;PGAM2 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2 0 9839800.0 3961200.0 1346700.0 4531900.0 False True 3835453.8742512567 1884444.3329477236 3344859.4359142384 1.0 0.491322381843426 0.8720896002346553 21.87096588066032 -9.754721427353397 6.050034768401237 1.0000000093078594 0.6817059910381599 0.4823215394959489 0.15544756597604478 1.9543113683148197e-08 4.077786825418207e-09 0.15051146304263063 0.05017048618568072 1.759051573319437e-10 9.754721427353397 -0.3182940182696995 AMEAVAAQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AMEAVAAQGK 10 0 P18669;P15259 P18669 PGAM1;PGAM2 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2 0 13108880.0 788080.0 5805300.0 6515500.0 False True 1079454.4730612144 5548802.650440095 4976673.090934628 1.0 5.140376726314635 4.6103594131407215 20.041870967039497 -10.231228010560955 4.1631863602508234 0.9975861398208586 4.875368069489773 0.9861654432658118 0.2163786634488097 6921596.478232558 4255224.912415052 143642.79187842162 0.07407217193172713 5.871809935135488e-11 10.231228010560955 3.8777819296689144 AMELLK(ub)VSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AMELLKVSK 9 1 Q9Y3U8;J3QSB5 Q9Y3U8 RPL36 60S ribosomal protein L36 1 15229210.0 763610.0 1108700.0 13356900.0 True False 739369.6185289819 1551409.6917941198 9858327.191589158 1.0 2.0982870446864426 13.333422072714948 19.4959362373316 -6.925829107368751 0.7802788051010541 0.8001704721280946 15.412604565042361 0.9956528353300599 0.36745979241880256 0.09486231741459962 0.08872237312724207 0.32680951220362053 1.0408735515923835 1.1862354338466466e-07 6.925829107368751 14.612434092914267 AMELLK(ub)VSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AMELLKVSK 9 1 Q9Y3U8;J3QSB5 Q9Y3U8 RPL36 60S ribosomal protein L36 1 14448610.0 763610.0 2005100.0 11679900.0 True False 634975.5486587867 1994298.1283188094 14122113.088244092 1.0 3.1407479115238726 22.24040456057437 19.276341512765875 -6.928125129267251 0.7620223707273829 0.6884548851478279 25.980625863399027 0.9961568029957268 0.5919342702783097 0.093623081458074 0.08253499136578192 0.53338496354193 1.7463453295199363 1.1799806097297006e-07 6.928125129267251 25.2921709782512 AMELSFALVNGNNIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AMELSFALVNGNNIR 15 0 O43747;O43747-2 O43747 AP1G1 AP-1 complex subunit gamma-1 0 17312900.0 6298900.0 11014000.0 0.0 False True 9555891.811273025 9048465.647225227 0.0 1.0 0.9468991304977741 0.0 23.187959089482646 -7.0685040186908354 1.0274922926167382 1.0073974802425525 1.3534714965108272e-20 0.9886746498785155 0.04888966750773426 0.0844770828041144 0.17086079984310487 0.039566495797923734 0.07044633570687066 8.540749443040115e-08 7.0685040186908354 -1.0073974802425525 down AMELSFALVNGNNIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AMELSFALVNGNNIR 15 0 O43747;O43747-2 O43747 AP1G1 AP-1 complex subunit gamma-1 0 15812900.0 6298900.0 9514000.0 0.0 False True 8154050.219881621 8984537.536521848 0.0 1.0 1.1018496690902504 0.0 22.959085411575096 -6.959243084331231 1.1878357561471975 1.0598020722375978 5.821380583204583e-20 0.9747133880818923 0.07905603052788852 0.10398069521184249 0.29086256614776507 0.055502076302518626 0.1046921528198233 1.0983908734144118e-07 6.959243084331231 -1.0598020722375978 down AMGAAQVVVTDLSATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AMGAAQVVVTDLSATR 16 0 Q00796;A0A6I8PIS1 Q00796 SORD Sorbitol dehydrogenase 0 4570100.0 1455600.0 2002200.0 1112300.0 False True 1908305.6960504511 1703479.5645144747 997209.8659350064 1.0 0.8926659748698034 0.5225629562385599 20.863860867947263 -6.94828638490588 0.5773502856089794 1.0044693140016743 0.392536869316439 0.999059853061689 0.006270844389322472 0.0841812325999055 0.038867053061446936 0.006589195141100125 0.030894794058389914 1.1264543983222071e-07 6.94828638490588 -0.6119324446852352 AMGIMNSFVNDIFER ddPTM_RPMI8226_Bortezomib_1h_R1 4 AMGIMNSFVNDIFER 15 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 773766420.0 389876020.0 257637000.0 126253400.0 False True 511131237.78474796 219198563.86116055 113189909.27612934 1.0 0.42884986801270664 0.22144979783801994 28.929118523436422 -12.896054183572472 0.1560731402767283 2.9757603725332187 3.8431622043510076e-19 0.9995537583144447 0.0069542106952338 7.931698963112789 0.11517205013177495 5.013187028705124 0.189905807259666 1.270415595366544e-13 12.896054183572472 -2.9757603725332187 AMGIMNSFVNDIFER ddPTM_RPMI8226_Bortezomib_2h_R1 4 AMGIMNSFVNDIFER 15 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 3756502200.0 1739044000.0 847173800.0 1170284400.0 False True 1683839000.124559 1185454716.2930038 863751807.8605509 1.0 0.7040190399469973 0.5129657929271483 30.64910705603313 -8.655840110639506 0.11318817760951212 1.5426127400752863 9.365559023871368e-10 0.9999599606222094 0.0012678180367590686 0.23152577149991227 0.030279297765371426 0.21313051819326626 0.17573679431881606 2.20881777917576e-09 8.655840110639506 -1.5426127391387303 AMGIMNSFVNDIFER ddPTM_RPMI8226_Bortezomib_8h_R1 4 AMGIMNSFVNDIFER 15 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 2798247000.0 359316000.0 1986990000.0 451941000.0 False True 545108641.5182621 1632396110.0762727 362614663.25722253 1.0 2.9946252650290894 0.6652154004516442 29.02196855038222 -6.679979839491955 1.9016250368658412 2.2620249211066206 0.67401377988706 0.3241548586608346 0.8453701804816423 0.4385825955030398 3.0662537942728174 0.35668697963376284 0.9408773920094785 2.089393120916971e-07 6.679979839491955 -1.5880111412195606 AMGIMNSFVNDIFER ddPTM_RPMI8226_Carfilzomib_1h_R1 4 AMGIMNSFVNDIFER 15 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 1183597750.0 389876020.0 250079030.0 543642700.0 False True 534023720.59727794 239029711.55383703 415245490.9328591 1.0 0.44760129996939957 0.7775787383909248 28.992328584959314 -10.328367579858238 6.019240160449736 1.0000351118707254 0.6125900191801729 0.6476214983849085 0.13471272512723384 6.348124760114178e-05 7.083200834518917e-06 0.13044682585232598 0.04347834507833263 4.694965660565564e-11 10.328367579858238 -0.3874450926905525 AMGIMNSFVNDIFER ddPTM_RPMI8226_Carfilzomib_2h_R1 4 AMGIMNSFVNDIFER 15 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 3114230600.0 1739044000.0 650163300.0 725023300.0 False True 1446092138.7118695 646660741.2555891 876622319.9010196 1.0 0.44717810431610044 0.6062008750575779 30.429512331467407 -10.736565979310038 10.436620844303004 1.0008429176681843 0.5266894896868933 0.9219463442460453 0.064920774300035 0.0012750448495943043 3.218373375399589e-05 0.0629453820611816 0.020953089807243835 1.8341464969563043e-11 10.736565979310038 -0.474153427981291 AMGIMNSFVNDIFER ddPTM_RPMI8226_Carfilzomib_8h_R1 4 AMGIMNSFVNDIFER 15 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 1148184700.0 359316000.0 391532600.0 397336100.0 False True 465141645.17725116 369743466.6251834 325025006.81267035 1.0 0.7949051014004251 0.6987656559730603 28.79309487247467 -13.999999999998648 0.10110064011983531 2.009682836146905 0.4974484086546792 0.9997881905233349 0.00182838698231181 12.072143399320481 0.09491273019496549 2.536117469658633 0.17943848782913902 1.0000000000031127e-14 13.999999999998648 -1.5122344274922255 AMGQGLPDEEQEK(ub)LLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AMGQGLPDEEQEKLLR 16 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 33648400.0 3876100.0 6902300.0 22870000.0 True False 5880327.0808673585 5670530.637083948 18349734.475722913 1.0 0.9643223172965975 3.1205295595591758 22.48746497350511 -6.903141068838194 0.9412213234433655 0.917914296672085 3.3618489303124264 0.9880646094029301 0.11013869342291936 0.1091292180896907 0.164677218721737 0.08721953851143711 0.2307176888019737 1.2498529832741227e-07 6.903141068838194 2.4439346336403416 up AMGQGLPDEEQEK(ub)LLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AMGQGLPDEEQEKLLR 16 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 6734000.0 1028700.0 961400.0 4743900.0 True False 1409038.1895722137 918922.1690753474 3623488.5236873226 1.0 0.6521627134565697 2.571604198171108 20.42627928328528 -6.8599920139131 1.1857622129791325 0.8112785113650441 2.664543505352277 0.9536295284478477 0.17980957223976976 0.1468135867331844 0.39224816179763006 0.1182713185373946 0.2760805472073553 1.3804096482319875e-07 6.8599920139131 1.8532649939872328 up AMGQGLPDEEQEK(ub)LLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AMGQGLPDEEQEKLLR 16 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 36276000.0 3876100.0 5474900.0 26925000.0 True False 5017687.859353725 5170217.002176105 22024926.273829985 1.0 1.0303982924202912 4.389457234326008 22.258591295597558 -6.908881259510901 0.9033190076627851 0.8922815928698792 4.8133303943989825 0.9904925274147101 0.15510214308929776 0.10516243061502699 0.14281424940179446 0.12628599425590326 0.3459629090645477 1.2334420226135645e-07 6.908881259510901 3.9210488015291034 up AMINLHIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AMINLHIQK 9 0 Q9NZ45 Q9NZ45 CISD1 CDGSH iron-sulfur domain-containing protein 1 0 11372500.0 2530200.0 4553900.0 4288400.0 False True 3317116.7024916536 3874475.8709631665 3844677.505237506 1.0 1.1680251912912356 1.1590419783390722 21.661498339105886 -10.299310888417128 5.266318416321087 0.9999666158760441 1.1635335848151467 0.9977419681880126 0.0036673813306455517 1.4378339557809646e-06 1.913006123870874e-07 0.003551651016624821 0.001183642234807697 5.019831177479437e-11 10.299310888417128 0.1635669689391026 AMK(ub)ELAEEEPHLVEQFQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AMKELAEEEPHLVEQFQK 18 1 Q5QNY5;P40855;P40855-5;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 29575900.0 6183500.0 8815400.0 14577000.0 True False 5987208.177176779 12335435.191703683 10758846.399373751 1.0 2.060298360549133 1.7969721581398228 22.51345200341308 -10.679050480659921 7.5886842848014 0.9965938752810836 1.9286352593444716 0.9431241446455596 0.10750247196794212 0.006195828342823359 0.00026204071533741176 0.10410126545483128 0.03469627363399745 2.0938690587100552e-11 10.679050480659921 0.932041384063388 AMK(ub)ELAEEEPHLVEQFQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AMKELAEEEPHLVEQFQK 18 1 Q5QNY5;P40855;P40855-5;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 25708200.0 8054400.0 8338600.0 9315200.0 True False 12219113.655514065 6850511.680220837 7474046.6370028 1.0 0.5606390015964404 0.6116684767581337 23.542636303609502 -10.420514756590654 5.227891286453801 1.0003866813097737 0.5861537391772763 0.9887254005900932 0.02083269599806694 9.397729901826754e-05 1.0416937926587772e-05 0.020189576303076627 0.006723723721420871 3.7973903586308833e-11 10.420514756590654 -0.4142329421324974 AMK(ub)ELAEEEPHLVEQFQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AMKELAEEEPHLVEQFQK 18 1 Q5QNY5;P40855;P40855-5;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 27589000.0 6183500.0 15239500.0 6166000.0 True False 5141854.225496795 15157401.788696105 7455282.09163717 1.0 2.947847434790244 1.4499209360445953 22.293857278847355 -6.579757101227757 2.268017721111465 2.326635438961111 1.453629043861637 0.0 0.8462577669881692 0.7000693679769435 6.773091179496012 0.3133687736821372 0.945935908335544 2.6317394993391754e-07 6.579757101227757 -0.873006395099474 AMK(ub)ELAEEEPHLVEQFQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AMKELAEEEPHLVEQFQK 18 1 Q5QNY5;P40855;P40855-5;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 28306300.0 8054400.0 14058000.0 6193900.0 True False 10426579.575960027 13275659.94202483 5066673.754780893 1.0 1.2732516781086836 0.48593824253380613 23.31376262570195 -6.812941721115268 1.4019098956402891 1.1484094288870372 0.4711862439088704 0.8674386307451103 0.11883616405193645 0.20280326396049284 0.7849538757991379 0.06663948392997106 0.15397188526155764 1.5383610623406288e-07 6.812941721115268 -0.6772231849781669 down AMK(ub)GFGTDEQAIIDCLGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AMKGFGTDEQAIIDCLGSR 19 1 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 1 8393400.0 0.0 5574300.0 2819100.0 True False 0.0 4742636.168451219 2527406.574716691 0.0 AMK(ub)GFGTDEQAIIDCLGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AMKGFGTDEQAIIDCLGSR 19 1 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 1 28990900.0 17909000.0 7711800.0 3370100.0 True False 17340488.59789097 10791161.956505734 2487369.7091671415 1.0 0.6223101440070268 0.14344288484868106 24.04764121374149 -7.536974042825984 0.4577701717481741 1.023176378253102 5.755529164492502e-27 0.9978324295134992 0.016318298348307236 0.11807282539905127 0.06367534753587126 0.021585716897536567 0.06943572260164413 2.904196229025626e-08 7.536974042825984 -1.023176378253102 down AMK(ub)GFGTDEQAIIDCLGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AMKGFGTDEQAIIDCLGSR 19 1 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 1 13068900.0 0.0 7682700.0 5386200.0 True False 0.0 7343252.910708514 4114090.492271055 0.0 AMK(ub)GFGTDEQAIIDCLGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AMKGFGTDEQAIIDCLGSR 19 1 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 1 29369300.0 17909000.0 5254800.0 6205500.0 True False 14892127.0032218 5226491.349403862 7503041.359009811 1.0 0.3509566731651664 0.5038260389121435 23.828046489175765 -10.247856054643785 8.3349331235073 1.0000003081686202 0.4273913560403606 0.9492576584035929 0.06240865723049843 3.5743657584087244e-07 3.224729390700436e-08 0.060426955391841904 0.020142307509407296 5.651242521910797e-11 10.247856054643785 -0.5726089521282596 AMK(ub)GFGTDEQAIIDCLGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AMKGFGTDEQAIIDCLGSR 19 1 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 1 33609000.0 14657000.0 10583000.0 8369000.0 True False 18973775.432663616 9994046.74679533 6845927.873191584 1.0 0.526729473649743 0.3608099978566324 24.177503441328806 -13.999999999998193 0.14611307597108195 3.275877678577468 0.16984857069972836 0.9995797266036428 0.005551906324137103 11.945240605327985 0.12017040557577176 7.728689198589309 0.17151456274809418 1.0000000000041598e-14 13.999999999998193 -3.1060291078777396 AMK(ub)GLGTDEESILTLLTSR ddPTM_RPMI8226_Bortezomib_2h_R1 2 AMKGLGTDEESILTLLTSR 19 1 P08758;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 1 21121500.0 10035900.0 4464100.0 6621500.0 True False 9717315.847873915 6246638.409973965 4887130.509257953 1.0 0.6428357900233004 0.5029300874610579 23.212126431741854 -13.999999999999998 0.12955409486344271 2.697240737257981 0.30588770950469674 0.9996476393776687 0.003928623346185953 11.93742317899533 0.11188727528084828 5.161305303931728 0.17520711442475262 1.0000000000000041e-14 13.999999999999998 -2.3913530277532846 AMK(ub)GLGTDEESILTLLTSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AMKGLGTDEESILTLLTSR 19 1 P08758;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 1 14779800.0 6004700.0 6646200.0 2128900.0 True False 4993174.10331375 6610395.601432593 2574043.1470785593 1.0 1.323886462730303 0.5155123962872195 22.251525781141034 -6.797974167336569 1.4642533935447963 1.179163605864721 0.5049139625207155 0.8261521031581344 0.13850319939490538 0.22366147644737555 0.9469376832623326 0.0744222503710594 0.1732902732307364 1.5923034374773247e-07 6.797974167336569 -0.6742496433440055 AMK(ub)GLGTDEESILTLLTSR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AMKGLGTDEESILTLLTSR 19 1 P08758;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 1 30347900.0 8579300.0 9154700.0 12613900.0 True False 11106072.973285867 8645232.897371937 10318299.629543697 1.0 0.778423923394602 0.9290682363030524 23.404845444620985 -10.112341982509479 4.730423288314022 1.0000092493103385 0.8537460798470566 0.5568845531854657 0.06150028321905647 81281971322.59126 15252316519.070717 8477209.49700631 0.021054885109115948 7.720723820319531e-11 10.112341982509479 -0.14626316946328188 AMK(ub)TVFGVEPDLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AMKTVFGVEPDLTR 14 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 1 13638000.0 5139200.0 3105900.0 5392900.0 True False 4976058.909055855 4346102.067054532 3980337.706467905 1.0 0.8734024549317785 0.7998976256539383 22.246572134233944 -13.999999999957916 0.06018296176314514 1.804035223646518 0.46929773829223026 0.9999537301954876 0.0005621333000094114 12.462173822265328 0.06279466403152403 1.508763825488082 0.3098065359390998 1.0000000000969013e-14 13.999999999957916 -1.3347374853542877 AMK(ub)TVFGVEPDLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AMKTVFGVEPDLTR 14 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 1 12187400.0 5139200.0 4525400.0 2522800.0 True False 4273472.505162628 4501020.771978429 3050305.815890736 1.0 1.0532466902597144 0.7137768669871565 22.02697740966822 -6.866798450766059 1.1508060408971703 1.0296070478956656 0.6950614541788673 0.9613870282147151 0.02929266508408304 0.13996653724505084 0.3484408409776434 0.019789327626192992 0.04661179794276572 1.35894396477547e-07 6.866798450766059 -0.33454559371679826 AMLEK(ub)EAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 AMLEKEAER 9 1 Q9UG63;Q9UG63-2;C9JHK9;C9JZV3 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 16885500.0 3590900.0 7535300.0 5759300.0 True False 5447657.829954489 6190566.841432373 4620971.830609133 1.0 1.136372186849351 0.848249279754734 22.377204659140645 -6.777998130177258 1.5436830732942672 1.0774180464571133 0.8461090171527328 0.760239563656417 0.05762315488943951 0.2536965553664812 1.1939593956537087 0.029404924100151875 0.06949991790332917 1.667254390775968e-07 6.777998130177258 -0.23130902930438046 AMLSANIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AMLSANIR 8 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 19589000.0 5084100.0 4884500.0 9620400.0 False True 6665304.334494439 4155751.6396318716 8624973.293393087 1.0 0.6234901560495788 1.2940104248139013 22.668239318883295 -6.754374841159711 1.6340103916971234 0.7797745768433406 1.2957713420172328 0.6674416917930407 0.1582570914013236 0.29247265829677316 1.5377231479325069 0.07647360963231983 0.1847866129791871 1.7604559345269628e-07 6.754374841159711 0.5159967651738921 AMLSANIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AMLSANIR 8 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 14074800.0 5084100.0 2808100.0 6182600.0 False True 6963829.162636431 2684028.8568550916 4722397.214643916 1.0 0.3854242822692892 0.6781322609091788 22.731449380406186 -10.490700829453232 6.277340424204762 1.000297445424369 0.5317782715892755 0.7733307783473317 0.11949753188486789 0.0004977502055762554 4.038401166625198e-05 0.11577433913485739 0.038567662575248574 3.230718886580126e-11 10.490700829453232 -0.46851917383509345 AMLSANIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AMLSANIR 8 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 6110800.0 2130800.0 1847900.0 2132100.0 False True 1771854.6104453064 1837944.995920568 2577912.252283428 1.0 1.0373001176765015 1.4549231280525559 20.756828797712053 -6.924416102748138 0.7912621776179454 0.9921683063192778 1.5296255716720784 0.9953229148101896 0.01410350227079251 0.09564180921266473 0.09264901093285406 0.012445215236312356 0.03901163946329174 1.1901012113751704e-07 6.924416102748138 0.5374572653528006 AMLSTGFK(ub)IPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AMLSTGFKIPK 11 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 4054700.0 1340700.0 2714000.0 0.0 True False 1757670.68335727 2309081.7790891393 0.0 1.0 1.3137169556009416 0.0 20.745233362221764 -6.879166134574659 1.3417623846227076 1.1638868122759276 3.9477954706442745e-18 0.9295030231105322 0.14873635760388154 0.14950700868062516 0.5410808014025763 0.0899084340512148 0.18339218250120032 1.32079028374681e-07 6.879166134574659 -1.1638868122759276 down AMLSTGFK(ub)IPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AMLSTGFKIPK 11 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 11606600.0 2767000.0 2380100.0 6459500.0 True False 4197741.29479631 1955352.559193821 5182776.993700569 1.0 0.4658106400262815 1.2346585055456725 22.00118182594584 -6.719882405024757 1.7601452872690173 0.6749585734859525 1.2334192525137087 0.5118002311357659 0.22479186887702782 0.35553506813238794 2.152688604381211 0.10141681633521299 0.2545902395216703 1.9059767340637843e-07 6.719882405024757 0.5584606790277562 AMLSTGFK(ub)IPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AMLSTGFKIPK 11 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 6395300.0 1340700.0 3183700.0 1870900.0 True False 1836393.0210551848 3043033.6069119847 1429031.9523949947 1.0 1.6570709929857328 0.7781732646608939 20.808443423744656 -6.70654989420896 1.8071745972120008 1.4053533750036353 0.7804066152627229 0.4489018449766513 0.2770383593523741 0.3820254338231928 2.4297917339560766 0.12208638310208203 0.3114995300258267 1.9653961717696697e-07 6.70654989420896 -0.6249467597409124 AMMYSGELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AMMYSGELK 9 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 10812200.0 1608500.0 5026500.0 4177200.0 False True 2108759.076736156 4276565.793143539 3744983.414531785 1.0 2.0280011312447406 1.7759181007666864 21.007962847645697 -10.004952772783454 5.3890735566700085 0.9999960934938753 1.9019596160073544 0.944658715293565 0.10291246625338689 4.84171996459751e-06 8.938079987798732e-07 0.09964499881787223 0.03321485565887358 9.886606003968598e-11 10.004952772783454 0.9019635225134791 AMMYSGELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AMMYSGELK 9 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 4860430.0 1503400.0 495830.0 2861200.0 False True 1455675.3899195527 693817.5047192924 2111765.885839895 1.0 0.47662927430382396 1.4507120890163574 20.47325724521418 -6.760772041985143 1.6096152510930624 0.6962848177725793 1.4543996168552014 0.6940748066380197 0.2201558531840653 0.2816315257947381 1.4382864586308592 0.1079087621794508 0.25911913671167625 1.734714297746346e-07 6.760772041985143 0.758114799082622 AMMYSGELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AMMYSGELK 9 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 8292300.0 1608500.0 3150300.0 3533500.0 False True 2203205.9180780635 3011109.3293510173 2698960.0747168246 1.0 1.3666944631202322 1.2250148987758827 21.071172909168588 -10.190288218769021 5.320684706236318 0.9999854501889274 1.295854680948134 0.8532451013395652 0.05784043993751365 9.983341169155948e-06 1.5193470563198727e-06 0.05600651823021861 0.01866792171790302 6.45225883892189e-11 10.190288218769021 0.29586923075920657 AMQDAEVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AMQDAEVSK 9 0 P38646;H0YBG6 P38646 HSPA9 Stress-70 protein, mitochondrial 0 3754800.0 1527400.0 0.0 2227400.0 False True 1478913.5230564894 0.0 1643977.1194323308 1.0 0.0 1.1116113916077408 20.49610626509784 -10.677211300606386 4.305534800301976 1.0181048468034393 0.5558056958105001 0.17553074465159513 0.45381345028457704 0.07951358129518199 0.005961180550858717 0.4429994716330336 0.14646766126967978 2.1027551213595514e-11 10.677211300606386 -0.46229915099293917 AMQIQEQK(ub)VQLEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AMQIQEQKVQLEER 14 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 2054830.0 739230.0 0.0 1315600.0 True False 614702.4984416574 0.0 1590685.8773528808 1.0 0.0 2.587732897434865 19.229528823313967 -6.80192678459996 1.448026539934641 0.4495977285238367 2.625183378572932 0.8377454599418351 0.4291848066005709 0.2180137699841232 0.9022693789804078 0.23314976878710839 0.5415981522314067 1.5778772532239005e-07 6.80192678459996 2.1755856500490953 AMQNNAKPEQK(ub)EGDTK ddPTM_RPMI8226_Bortezomib_1h_R1 2 AMQNNAKPEQKEGDTK 16 2 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 284879400.0 88980000.0 114327400.0 81572000.0 True False 116653641.68354583 97270197.56471469 73131711.9338761 1.0 0.8338376424508553 0.6269132354415939 26.79765610505611 -6.9681646914615705 0.29878860545118685 1.0364081947931412 0.4178700114396301 0.9999643184447362 0.0009116113098349996 0.07690282315562202 0.011150315656402714 0.003453736480812638 0.018582085897289054 1.0760570780757263e-07 6.9681646914615705 -0.6185381833535111 AMQNNAKPEQK(ub)EGDTK ddPTM_RPMI8226_Bortezomib_2h_R1 2 AMQNNAKPEQKEGDTK 16 2 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 158098900.0 71153800.0 49688300.0 37256800.0 True False 68895061.56662089 69529097.31106138 27498126.399958003 1.0 1.0092029200645591 0.3991305875148623 26.037897237726167 -6.903478413598117 0.9390399107114868 1.0230010073017808 0.3303761657436901 0.9882181549867575 0.030983556374614647 0.10888925070622972 0.16334160742594162 0.02457560090900665 0.06513110255472108 1.248882518162791e-07 6.903478413598117 -0.6926248415580907 down AMQNNAKPEQK(ub)EGDTK ddPTM_RPMI8226_Bortezomib_8h_R1 2 AMQNNAKPEQKEGDTK 16 2 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 274675900.0 50733900.0 127779000.0 96163000.0 True False 76967035.44491017 104975839.10811614 77156340.90025985 1.0 1.3639064893340411 1.002459565374389 26.19773734400517 -10.065161282193879 12.559975437799318 0.9999995813141512 1.1831830273673738 0.2551033470373645 0.14756008880014784 0.0 0.0 0.1428744416218756 0.04762481387395852 8.606740677636478e-11 10.065161282193879 0.18318344605322257 AMQNNAKPEQK(ub)EGDTK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AMQNNAKPEQKEGDTK 16 2 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 289551000.0 88980000.0 104843600.0 95727400.0 True False 121878310.59408543 100211263.08057837 73118559.68768865 1.0 0.8222239264074725 0.5999308599805697 26.860866166579 -6.9681052708843225 0.3000192484111048 1.0385442473601727 0.37664505780770524 0.9999635963679049 0.0009874582405464021 0.07692248657258541 0.011219455368118414 0.0036875559349911673 0.019936045432622816 1.0762043152840163e-07 6.9681052708843225 -0.6618991895524675 AMQNNAKPEQK(ub)EGDTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AMQNNAKPEQKEGDTK 16 2 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 139649800.0 62185000.0 48240300.0 29224500.0 True False 51709582.762596935 47980419.92895014 35335207.8311791 1.0 0.927882558040205 0.6833396431258404 25.623928328174962 -6.948670341245188 0.5732623099201398 1.0030030257460116 0.5962630195324053 0.9990927098224045 0.0040818424640931125 0.08402425197203665 0.03820729318629362 0.004308542901274078 0.02039180905177024 1.1254589489382491e-07 6.948670341245188 -0.4067400062136063 AMQNNAKPEQK(ub)EGDTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AMQNNAKPEQKEGDTK 16 2 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 23415300.0 9105000.0 11576000.0 2734300.0 True False 11786601.9863821 10931785.423878182 2236685.456287219 1.0 0.9274755723921492 0.1897650789321147 23.490644521292534 -6.925919741256788 0.7795602868134779 1.0130762723212297 0.0529395970272667 0.9956736214463969 0.024077253058692537 0.09481273377814034 0.08847136217780932 0.021424622537333127 0.06830886317666422 1.1859879015472987e-07 6.925919741256788 -0.960136675293963 down AMQQQVQK(ub)LK ddPTM_RPMI8226_Bortezomib_1h_R1 2 AMQQQVQKLK 10 1 Q9NZL4;Q9NZL4-3 Q9NZL4 HSPBP1 Hsp70-binding protein 1 1 74166900.0 33642300.0 32351500.0 8173100.0 True False 44105381.09249668 27524782.305159282 7327426.013911163 1.0 0.6240685744770011 0.16613451312311014 25.394451347247387 -7.523670688688277 0.42878741540693294 1.0300239714233879 1.6680937157441427e-25 0.9984304854732426 0.013508336670417868 0.1186920158427799 0.055868663532897746 0.020431923112814013 0.06821686277253543 2.9945344335345815e-08 7.523670688688277 -1.0300239714233879 down AMQQQVQK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 2 AMQQQVQKLK 10 1 Q9NZL4;Q9NZL4-3 Q9NZL4 HSPBP1 Hsp70-binding protein 1 1 60717700.0 27447300.0 24925000.0 8345400.0 True False 26576000.48539244 34877682.48215785 6159489.3833665075 1.0 1.3123751446847107 0.2317688617876149 24.6636206689743 -6.829379352580013 1.3306714098406907 1.1669849330400144 0.2030548772098026 0.9046322101106009 0.14021880152270366 0.18157608202159206 0.6290160152771257 0.08274118389755424 0.19041674887642013 1.481223683464863e-07 6.829379352580013 -0.9639300558302117 down AMQQQVQK(ub)LK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AMQQQVQKLK 10 1 Q9NZL4;Q9NZL4-3 Q9NZL4 HSPBP1 Hsp70-binding protein 1 1 56457310.0 33642300.0 20088420.0 2726590.0 True False 46080767.45897282 19200847.180878513 2082625.5978837265 1.0 0.41667811192540666 0.04519511528834572 25.457661408770278 -8.334554719553239 0.45220428120796236 1.0605155351306919 8.870150086171671e-20 0.9953863166345309 0.026692974357636172 0.14174745955745224 0.13542234187155702 0.06975296893040946 0.07609728534741574 4.628553419839358e-09 8.334554719553239 -1.0605155351306919 AMQQQVQK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AMQQQVQKLK 10 1 Q9NZL4;Q9NZL4-3 Q9NZL4 HSPBP1 Hsp70-binding protein 1 1 82501780.0 27447300.0 49869500.0 5184980.0 True False 22823646.07155788 49600843.10517932 6269135.345361154 1.0 2.1732217082962197 0.274677206512309 24.444025944408576 -6.739500849881847 1.6883765694040553 1.698421591262328 0.2736222987778211 0.6028881050064894 0.4929390980102632 0.3186529646326765 1.7833473076192743 0.2309834931824297 0.567155865514508 1.8217935079746252e-07 6.739500849881847 -1.4247992924845068 AMQQQVQK(ub)LK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AMQQQVQKLK 10 1 Q9NZL4;Q9NZL4-3 Q9NZL4 HSPBP1 Hsp70-binding protein 1 1 65410500.0 32101800.0 29433900.0 3874800.0 True False 41556412.92108083 27795877.59052248 3169626.158805445 1.0 0.6688709548465894 0.07627285263588163 25.308567792844595 -7.441222274176825 0.5968510494633901 1.0016364279895096 6.510681073565595e-20 0.9947279687402077 0.027744724157511547 0.11218749015311306 0.08887315145513332 0.02647188745136093 0.06868273493755703 3.620576479999304e-08 7.441222274176825 -1.0016364279895096 down AMQSLK(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AMQSLKSR 8 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783;Q9NQ39 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 3810070.0 686970.0 1332500.0 1790600.0 True False 900624.3226269432 1133696.19404432 1605325.8886480443 1.0 1.2587892260532694 1.7824589546567273 19.780565914652033 -6.959815838321893 0.43802875224270776 0.9808862667288742 2.0807120984815155 0.9997632886300192 0.0050076686003068015 0.0797670720047144 0.02137555812005021 0.006887745619157299 0.04340582249827219 1.0969432540541695e-07 6.959815838321893 1.0998258317526413 AMQSLK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AMQSLKSR 8 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783;Q9NQ39 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 4557850.0 543450.0 2020800.0 1993600.0 True False 526198.4772194906 2827715.978332787 1471416.3532819834 1.0 5.373858155718827 2.796314350921656 19.005247547891074 -9.598511772097691 8.81228055838673 1.0000388955267967 4.085086253320237 0.6563718681373639 1.0522778521437934 0.0 0.0 1.0188636491256806 0.3396212163752268 2.5205088571531414e-10 9.598511772097691 3.0850473577934405 AMQSLK(ub)SR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AMQSLKSR 8 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783;Q9NQ39 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 3146450.0 686970.0 910580.0 1548900.0 True False 940961.3736662037 870347.5647146141 1183081.720596828 1.0 0.9249556773234359 1.257311674747357 19.843775976174925 -6.847380352764505 1.24756936477725 0.9600232912538209 1.2699478890974778 0.9364121575374699 0.03588895848430966 0.16036959402069478 0.4816279861873604 0.022523706239275205 0.052044408770573536 1.4210836645590261e-07 6.847380352764505 0.3099245978436569 AMQSLK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AMQSLKSR 8 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783;Q9NQ39 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 3514600.0 543450.0 2096400.0 874750.0 True False 451902.753917075 2085106.2770971793 1057656.1806129762 1.0 4.614059682140818 2.3404508413486194 18.78565282332535 -10.160494091763498 7.361579407453415 0.9999983636306228 3.4772552617447183 0.6128357027492554 0.9281969224369404 2.492958227161186e-05 2.84519601164335e-06 0.8987233941982837 0.29957426854993724 6.910443304582254e-11 10.160494091763498 2.4772568981140957 AMTAK(ub)GGDISVCEWYQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AMTAKGGDISVCEWYQR 17 1 P14854 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 1 21479400.0 3270700.0 8496300.0 9712400.0 True False 4287919.37350386 7228685.158318007 8707454.015919402 1.0 1.6858258116945677 2.0306944364963964 22.03184634812832 -9.945936071366967 0.16211135134661567 3.395691227199201e-17 2.485766394647318 0.9996676975533558 0.007809096375228435 1.4879799731648098 0.07413597588364623 0.9176999010615788 0.2724034666816934 1.1325670661035346e-10 9.945936071366967 2.485766394647318 AMTAK(ub)GGDISVCEWYQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AMTAKGGDISVCEWYQR 17 1 P14854 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 1 126884000.0 13758000.0 33176000.0 79950000.0 True False 20871891.844527505 27255483.5947289 64147847.45667012 1.0 1.305846340990653 3.0734083874380236 24.315058037637833 -6.936633072604793 0.6901720731600794 0.9785380859717984 3.5062898700087377 0.9976888597210326 0.043934890204062216 0.08933670067823497 0.06185863297958331 0.04174608279309533 0.15452150159172245 1.1570894328427832e-07 6.936633072604793 2.5277517840369392 up AMTAK(ub)GGDISVCEWYQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AMTAKGGDISVCEWYQR 17 1 P14854 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 1 20282800.0 3270700.0 7527600.0 9484500.0 True False 4479966.17734407 7195005.741555621 7244456.4394090185 1.0 1.6060401924331382 1.6170783779675466 22.09505640965121 -11.325139154225509 0.6484446408467905 3.4491196462799272e-15 1.6154237188963336 0.9999669889662307 0.0016565794967638838 4.056562981653241 0.3262891372594221 5.815790787252238 0.0018126038151050515 4.729996787488467e-12 11.325139154225509 1.61542371889633 AMTAK(ub)GGDISVCEWYQR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AMTAKGGDISVCEWYQR 17 1 P14854 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 1 125821000.0 26331000.0 36280000.0 63210000.0 True False 34085998.56160651 34260986.10731692 51706428.58937028 1.0 1.005133707477988 1.5169404087111273 25.022675912144713 -6.90909426499958 0.9018811034165853 0.9836957818695499 1.581817121955578 0.990575183434131 0.023541007074147774 0.10502018501165715 0.14203904318748078 0.019187407921716457 0.05263934300501181 1.2328372129450687e-07 6.90909426499958 0.5981213400860282 AMTGVEQWPYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AMTGVEQWPYR 11 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 AMTHVINQGMAMYWGTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AMTHVINQGMAMYWGTSR 18 0 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28;Q13303-5;A0A590UJJ4;Q5TG81;B7Z8E5;F8W6W4;A0A087X1P8;Q14722;Q14722-2;Q14722-3;A0A590UJ35 Q13303-3 KCNAB2;KCNAB1 Voltage-gated potassium channel subunit beta-2;Voltage-gated potassium channel subunit beta-1 0 8824300.0 2369900.0 1628200.0 4826200.0 False True 3106961.850144248 1385278.9066738926 4326831.120179382 1.0 0.4458628633015168 1.3926244765375857 21.567073096285824 -6.748094989974645 1.6570998126168355 0.673406570150966 1.3942101678733165 0.6406087140290997 0.2328333312939302 0.30340007829797877 1.6386196943009577 0.1110268389726273 0.27006286385828043 1.7860968725534196e-07 6.748094989974645 0.7208035977223505 AMTHVINQGMAMYWGTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AMTHVINQGMAMYWGTSR 18 0 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28;Q13303-5;A0A590UJJ4;Q5TG81;B7Z8E5;F8W6W4;A0A087X1P8;Q14722;Q14722-2;Q14722-3;A0A590UJ35 Q13303-3 KCNAB2;KCNAB1 Voltage-gated potassium channel subunit beta-2;Voltage-gated potassium channel subunit beta-1 0 8531500.0 2369900.0 2311400.0 3850200.0 False True 3246116.074139391 2209274.70522234 2940862.0573580684 1.0 0.680590174461972 0.905963308209103 21.630283157808716 -10.091158011293995 5.572045264592393 1.0000017835309203 0.7932767413354842 0.528700724055224 0.09200819656893783 2.038535895957998e-06 3.325910401532098e-07 0.08908732183267316 0.029695517752145576 8.106660559525034e-11 10.091158011293995 -0.20672504219543608 AMTHVINQGMAMYWGTSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AMTHVINQGMAMYWGTSR 18 0 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28;Q13303-5;A0A590UJJ4;Q5TG81;B7Z8E5;F8W6W4;A0A087X1P8;Q14722;Q14722-2;Q14722-3;A0A590UJ35 Q13303-3 KCNAB2;KCNAB1 Voltage-gated potassium channel subunit beta-2;Voltage-gated potassium channel subunit beta-1 0 6410000.0 2920300.0 1074700.0 2415000.0 False True 2428358.841225566 1068910.3777887528 2919965.3343016175 1.0 0.44017809873984093 1.2024439241557656 21.211550195285263 -6.7098807687112885 1.7955272630011674 0.6557898547088946 1.2006532174199176 0.4645421520331132 0.23591078760945292 0.3753364678882167 2.3586992100542545 0.10455781900909614 0.26567461069288023 1.9503799839499203e-07 6.7098807687112885 0.544863362711023 AMTK(ub)DNNLLGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 AMTKDNNLLGK 11 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6;P11142-2;P54652 A8K7Q2;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 139274800.0 81679800.0 25970200.0 31624800.0 True False 107083008.78830846 22095547.39104675 28352569.062502388 1.0 0.20634036754353122 0.2647718754200524 26.67415434019983 -10.347377866913591 8.670461586542817 1.0000016780715397 0.23555612148179458 0.9956371992778404 0.02385456319981553 7.737913657974765e-07 5.823271416269881e-08 0.02309713241260064 0.007699027166994826 4.493886848075295e-11 10.347377866913591 -0.7644455565897451 AMTK(ub)DNNLLGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 AMTKDNNLLGK 11 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6;P11142-2;P54652 A8K7Q2;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 185878100.0 51281100.0 86321600.0 48275400.0 True False 49653209.55035496 120790265.04119706 35630624.50904345 1.0 2.432677890010306 0.7175895542645487 25.565383639824688 -6.685041652617064 1.8838197420889267 1.9023227383306711 0.7238095321546011 0.3474289733871968 0.6065427748498812 0.4274092596156173 2.9366609319683703 0.25794277102821184 0.6759826772733959 2.0651820773936975e-07 6.685041652617064 -1.1785132061760701 AMTK(ub)DNNLLGK ddPTM_RPMI8226_Bortezomib_8h_R1 2 AMTKDNNLLGK 11 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6;P11142-2;P54652 A8K7Q2;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 480805400.0 185885000.0 178464500.0 116455900.0 True False 282001135.0138101 146616115.625497 93438340.32056582 1.0 0.5199132110525617 0.33134029874025145 28.071125728373676 -13.999999706107422 0.12913719853819966 3.2812933805454203 0.06434034291252227 0.9996495402086739 0.005269721711618416 11.938127260952262 0.11166516889692812 6.91815788300141 0.23737761817485664 1.0000006767128976e-14 13.999999706107422 -3.216953037632898 AMTK(ub)DNNLLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AMTKDNNLLGK 11 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6;P11142-2;P54652 A8K7Q2;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 145191600.0 81679800.0 29200800.0 34311000.0 True False 111879029.37359834 27910612.101867445 26207448.457226254 1.0 0.2494713464903719 0.23424808566859798 26.737364401722722 AMTK(ub)DNNLLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AMTKDNNLLGK 11 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6;P11142-2;P54652 A8K7Q2;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 245668100.0 51281100.0 140895900.0 53491100.0 True False 42642506.78792327 140136865.82105362 64675841.69509776 1.0 3.2863186612833375 1.5166988661514271 25.345788915258964 -6.581570016773618 2.2613054319848898 2.555489947852664 1.521256789321104 0.0 0.9928633858398769 0.6946242438175116 6.683497661508472 0.368371588650682 1.1090547466151874 2.6207764840922017e-07 6.581570016773618 -1.03423315853156 AMTK(ub)DNNLLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AMTKDNNLLGK 11 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6;P11142-2;P54652 A8K7Q2;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 474029000.0 185885000.0 200928400.0 87215600.0 True False 240631796.84114638 189746557.90974104 71343255.70762664 1.0 0.7885348503423372 0.29648307764881154 27.842252050466126 -6.956981105665856 0.47608328873844324 1.0122571240239981 0.0523813853263497 0.9996413035946048 0.005581887940778596 0.0807977941251947 0.025254418442142126 0.0068836199862092814 0.040596774278463796 1.1041266547839903e-07 6.956981105665856 -0.9598757386976484 down AMTK(ub)DNNLLGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 AMTKDNNLLGR 11 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931;P17066 P0DMV9;Q53FA3;P17066 HSPA1B;HSPA1A;HSPA1L;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6 1 96786300.0 32681900.0 31119300.0 32985100.0 True False 42846287.391969755 26476421.74208134 29572118.267421376 1.0 0.6179396945146651 0.6901909142532563 25.35266686520645 -10.78877795271131 7.10749132892271 1.0109077519270042 0.6540653043839607 0.9683202025964505 0.02949643694220876 0.0050967408211511234 0.00015146591272145613 0.0285512239912184 0.0095199340874693 1.6263800833359006e-11 10.78877795271131 -0.3568424475430435 AMTK(ub)DNNLLGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 AMTKDNNLLGR 11 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931;P17066 P0DMV9;Q53FA3;P17066 HSPA1B;HSPA1A;HSPA1L;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6 1 183912570.0 45689370.0 47238700.0 90984500.0 True False 44238985.95844674 66101359.256566234 67152929.97350764 1.0 1.494187939087361 1.5179581656004446 25.398814980853622 -11.585467154684938 0.48934263148819046 9.395316991733977e-13 1.517076652848806 0.9998552441750568 0.0028726525755491945 4.483620161349462 0.2414698150030472 4.736334760426322 0.004936971910336154 2.5973641703739053e-12 11.585467154684938 1.5170766528478665 AMTK(ub)DNNLLGR ddPTM_RPMI8226_Bortezomib_8h_R1 2 AMTKDNNLLGR 11 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931;P17066 P0DMV9;Q53FA3;P17066 HSPA1B;HSPA1A;HSPA1L;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6 1 592726900.0 79616700.0 282969200.0 230141000.0 True False 120784354.66042994 232471135.4115491 184653530.47561622 1.0 1.9246792025764639 1.5287868283499668 26.847858351877775 -10.07163144495233 4.5986856995145615 0.9999637331617844 1.726733015464532 0.8179493727162683 0.16162238508209756 56093575.92289925 2.2505117939088377 23219.935833674106 0.055327641302521435 8.479467013587017e-11 10.07163144495233 0.7267692823027475 AMTK(ub)DNNLLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AMTKDNNLLGR 11 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931;P17066 P0DMV9;Q53FA3;P17066 HSPA1B;HSPA1A;HSPA1L;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6 1 96330000.0 32681900.0 26938200.0 36709900.0 True False 44765281.6251386 25747981.251285136 28039777.684122626 1.0 0.5751774660304153 0.6263733113292083 25.415876926729343 -10.592881014346577 6.832144381362423 1.0006602700778817 0.6007753886798117 0.987816490919641 0.02090061632208462 0.00021052823081149999 1.254508022436532e-05 0.02026821274888701 0.006745644911742052 2.5534007737730417e-11 10.592881014346577 -0.39988488139807 AMTK(ub)DNNLLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AMTKDNNLLGR 11 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931;P17066 P0DMV9;Q53FA3;P17066 HSPA1B;HSPA1A;HSPA1L;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6 1 144350070.0 45689370.0 65862000.0 32798700.0 True False 37992735.537282534 65507188.33341649 39656756.52594557 1.0 1.7242029932046834 1.0437983989605095 25.1792202562879 -10.600319813543878 5.628315911699332 0.9978382490495613 1.3840006960825966 0.29809111174318315 0.27777401242394273 0.007571358788487938 0.0005376597881511959 0.270254904079492 0.08965117701059509 2.510037364527794e-11 10.600319813543878 0.38616244703303526 AMTK(ub)DNNLLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AMTKDNNLLGR 11 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931;P17066 P0DMV9;Q53FA3;P17066 HSPA1B;HSPA1A;HSPA1L;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6 1 425069900.0 79616700.0 220915600.0 124537600.0 True False 103065387.62978457 208621452.65958038 101873034.66368555 1.0 2.0241659926507807 0.9884311019099641 26.618984673970225 -6.6487576730384115 2.0130977422635223 1.6652363602196087 0.992792087312532 0.18900663218696823 0.43725951577932093 0.5115601430532539 3.972337382142544 0.17624902119944785 0.48425605228547175 2.2451343109092202e-07 6.6487576730384115 -0.6724442729070768 AMTTGAIAAMLSTILYSR ddPTM_RPMI8226_Bortezomib_8h_R1 3 AMTTGAIAAMLSTILYSR 18 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 4954904300.0 1692987000.0 1484357300.0 1777560000.0 False True 2568385052.9285564 1219462142.4784796 1426224486.867776 1.0 0.4747972431501301 0.5553001039472443 31.258214361861988 -10.71903238893649 6.866875851013295 1.0057059562469177 0.515048673548809 0.9797510120285162 0.03286515529787219 0.002881256916186617 0.00011789043041141343 0.031935822901720104 0.010607183261598286 1.9097108303017848e-11 10.71903238893649 -0.4906572826981087 AMTTGAIAAMLSTILYSR ddPTM_RPMI8226_Carfilzomib_8h_R1 3 AMTTGAIAAMLSTILYSR 18 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 3689769200.0 1692987000.0 1120312200.0 876470000.0 False True 2191605045.262939 1057965841.2364284 716961453.3416439 1.0 0.4827356295438252 0.3271398990850681 31.029340683954437 -13.99999999999966 0.16832891687234802 3.5973646933683905 0.18741616180064632 0.999516966819173 0.0063212539856774795 12.075701629288792 0.12988768016885704 10.240118617386976 0.1288116399342862 1.0000000000007813e-14 13.99999999999966 -3.409948531567744 AMVASGSELGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AMVASGSELGK 11 0 P54819;F8W1A4;P54819-2;P54819-5;P54819-3;F8VZG5;A0A5F9ZHP2;P54819-6;G3V213;P54819-4 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 0 5900300.0 433800.0 2745600.0 2720900.0 False True 568716.0009251757 2335967.182264974 2439367.3687157766 1.0 4.1074405827598826 4.289253976936578 19.11734886977787 -10.166991731948196 0.6164491731683238 2.6759461282723547e-13 4.266612864808237 0.9997061041422648 0.025878656455596588 1.4546959886295505 0.29776077456463224 2.6452035064347985 0.030878836375398958 6.807823192312063e-11 10.166991731948196 4.2666128648079695 AMVASGSELGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AMVASGSELGK 11 0 P54819;F8W1A4;P54819-2;P54819-5;P54819-3;F8VZG5;A0A5F9ZHP2;P54819-6;G3V213;P54819-4 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 0 7340500.0 2294800.0 732600.0 4313100.0 False True 2221952.830110011 1025131.0004585307 3183369.7197735365 1.0 0.46136487983310404 1.4326900538279765 21.083396759368597 -6.756178964434911 1.6266483022889515 0.6856394296409009 1.4356039731675627 0.6751858053251492 0.22644667046940817 0.28942147698532056 1.5083652517574784 0.10988097305875326 0.26508873724413623 1.7531579101846134e-07 6.756178964434911 0.7499645435266619 AMVASGSELGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AMVASGSELGK 11 0 P54819;F8W1A4;P54819-2;P54819-5;P54819-3;F8VZG5;A0A5F9ZHP2;P54819-6;G3V213;P54819-4 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 0 5623400.0 433800.0 2921700.0 2267900.0 False True 594187.5830042056 2792609.6332301227 1732268.728866646 1.0 4.699878814549979 2.915356662467289 19.180558931300762 -9.17813770353367 10.979860996536637 1.0000004948594883 3.8076177385086702 0.7674652285606294 0.7285281178828407 0.0 0.0 0.7053943064397445 0.2351314389836445 6.635326480241602e-10 9.17813770353367 2.807617243649182 AMVEYEIDLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AMVEYEIDLQK 11 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 2063400.0 2063400.0 0.0 0.0 False True 2705137.3819940216 0.0 0.0 1.0 0.0 0.0 21.367270433353543 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 AMVEYEIDLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AMVEYEIDLQK 11 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 15799700.0 3968300.0 3343300.0 8488100.0 False True 3842328.488637598 4678297.1250791745 6264811.972458274 1.0 1.2175682373107022 1.6304727695678183 21.87354943259366 -6.961057408558626 0.4202656190985916 0.9818009828288237 1.8818226186934803 0.9998074282264591 0.003628488354221415 0.07932553924823606 0.019751465380253908 0.0053421796884145995 0.03436863065118668 1.0938117678253742e-07 6.961057408558626 0.9000216358646567 AMVEYEIDLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AMVEYEIDLQK 11 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 4431600.0 2063400.0 2368200.0 0.0 False True 2826294.7412883285 2263565.0934098586 0.0 1.0 0.800894917413335 0.0 21.430480494876434 -7.2493217184651995 0.8536144186125538 0.9893005390683337 1.0185988253976023e-16 0.9888291125809153 0.04567895806172022 0.09832572407592641 0.13819253526579356 0.038705511003224606 0.06815345913446072 5.6322027660166506e-08 7.2493217184651995 -0.9893005390683336 down AMYPGTFYFQFK ddPTM_RPMI8226_Bortezomib_1h_R1 2 AMYPGTFYFQFK 12 0 Q9NRW3 Q9NRW3 APOBEC3C DNA dC->dU-editing enzyme APOBEC-3C 0 24754180.0 6993680.0 13385600.0 4374900.0 False True 9168782.206893452 11388520.656660134 3922227.3150040973 1.0 1.2420974126856013 0.42778061758901986 23.128298697828686 -6.82705311280511 1.3410827736954718 1.1296486165412543 0.40716743618682383 0.8998324535947549 0.10805944071375652 0.18448245939685864 0.6499367069228854 0.06328428256979182 0.14566044219711594 1.4891789448239857e-07 6.82705311280511 -0.7224811803544304 down AMYPGTFYFQFK ddPTM_RPMI8226_Bortezomib_2h_R1 2 AMYPGTFYFQFK 12 0 Q9NRW3 Q9NRW3 APOBEC3C DNA dC->dU-editing enzyme APOBEC-3C 0 82950100.0 33524200.0 23213500.0 26212400.0 False True 32459992.62121933 32482771.606803272 19346586.084855888 1.0 1.0007017557227986 0.5960132619441474 24.952159336145126 -6.906506974979794 0.9192030835860612 1.0139557399581878 0.5474424222582361 0.9895350533684738 0.019498754433793765 0.10677315873705537 0.1516358652662937 0.01569315441205515 0.04233970717368476 1.2402037066865327e-07 6.906506974979794 -0.46651331769995164 AMYPGTFYFQFK ddPTM_RPMI8226_Bortezomib_8h_R1 2 AMYPGTFYFQFK 12 0 Q9NRW3 Q9NRW3 APOBEC3C DNA dC->dU-editing enzyme APOBEC-3C 0 318851900.0 115698900.0 85883900.0 117269100.0 False True 175523690.02259064 70557247.03102654 94090810.98412746 1.0 0.40198133381280626 0.5360576169063992 27.387090519951123 -9.97016191105502 7.148728003754208 1.0000000230699269 0.46901947536014804 0.9543625473888929 0.054736413364710045 2.011933545067232e-08 2.872279509661605e-09 0.052998306717362095 0.017666101449386993 1.0711199023150948e-10 9.97016191105502 -0.5309805477097789 AMYPGTFYFQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AMYPGTFYFQFK 12 0 Q9NRW3 Q9NRW3 APOBEC3C DNA dC->dU-editing enzyme APOBEC-3C 0 48296680.0 6993680.0 11939600.0 29363400.0 False True 9579432.493095549 11412068.993022686 22428369.678205762 1.0 1.1913095061996652 2.341304633063721 23.191508759351578 -6.935796010834105 0.6975822586890168 0.9856874757516116 2.616482922778848 0.9975597102956836 0.029262963054928634 0.08973795347461061 0.06374330770997012 0.02764824721057263 0.10094594368814788 1.1593217645198402e-07 6.935796010834105 1.6307954470272363 up AMYPGTFYFQFK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AMYPGTFYFQFK 12 0 Q9NRW3 Q9NRW3 APOBEC3C DNA dC->dU-editing enzyme APOBEC-3C 0 93884500.0 33524200.0 25799300.0 34561000.0 False True 27876857.67387396 25660314.05013992 41787545.307991 1.0 0.920488038872065 1.4990048662175457 24.732564611579402 -6.872165147402068 1.1225152299108234 0.9543798676433923 1.5343190101424056 0.9667998553325341 0.04665286466676872 0.13479903730834664 0.31612496027994674 0.03220909383973102 0.07656004767495271 1.3422544504205333e-07 6.872165147402068 0.5799391424990132 AMYPGTFYFQFK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AMYPGTFYFQFK 12 0 Q9NRW3 Q9NRW3 APOBEC3C DNA dC->dU-editing enzyme APOBEC-3C 0 283086600.0 115698900.0 99864700.0 67523000.0 False True 149774506.81627926 94307141.6568735 55234506.84448743 1.0 0.629660839227835 0.36878443480532225 27.158216842043572 -8.032919393172346 0.188786329752655 1.2749059515018664 1.921711584094855e-11 0.9998675579327958 0.0029804384433155477 0.0998254732342768 0.03367126789334333 0.08547943467804898 0.10716908962637856 9.27001862740912e-09 8.032919393172346 -1.2749059514826493 down ANAEEMTK(ub)YHSDDYIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANAEEMTKYHSDDYIK 16 1 Q13547;Q5TEE2 Q13547 HDAC1 Histone deacetylase 1 1 8683100.0 1626400.0 1929800.0 5126900.0 True False 1574770.8222463517 2700379.2037740536 3784011.086296851 1.0 1.7147759951013466 2.4028963661512983 20.586710456561363 -6.971588822777933 0.21691019888954727 0.6700241979506693 3.467009357183424 0.999992264112047 0.00159304604234631 0.07579043838751404 0.007156188712964323 0.019519231473388743 0.07020868618668295 1.0676064212038282e-07 6.971588822777933 2.796985159232755 ANAEEMTK(ub)YHSDDYIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANAEEMTKYHSDDYIK 16 1 Q13547;Q5TEE2 Q13547 HDAC1 Histone deacetylase 1 1 34958400.0 4015400.0 6732000.0 24211000.0 True False 6091655.3650614675 5530622.002643928 19425685.23794175 1.0 0.9079013291468634 3.1889008937303425 22.538402893096016 -6.897489164070618 0.9769885568272123 0.8985210464426845 3.416500565462437 0.9852756785494563 0.12792505904992207 0.11327772655827313 0.1880190700629959 0.09864800409670212 0.253584197210155 1.266224860249444e-07 6.897489164070618 2.5179795190197525 up ANAEEMTK(ub)YHSDDYIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANAEEMTKYHSDDYIK 16 1 Q13547;Q5TEE2 Q13547 HDAC1 Histone deacetylase 1 1 7636400.0 1626400.0 2810300.0 3199700.0 True False 1352423.6617365554 2795160.3560991283 3868742.4762587533 1.0 2.0667786546340463 2.860599519008092 20.36711573199564 -7.575220578972273 0.15752682765579495 2.418924927033309e-17 4.468833461948994 0.9999767155824714 0.0036784232205452185 0.1377799268774068 0.016374296524836605 0.15931100305563015 0.2653770096737949 2.6593740157375303e-08 7.575220578972273 4.468833461948994 ANAEEMTK(ub)YHSDDYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANAEEMTKYHSDDYIK 16 1 Q13547;Q5TEE2 Q13547 HDAC1 Histone deacetylase 1 1 50984300.0 4015400.0 7276900.0 39692000.0 True False 5198014.455367229 6871934.1180908 32468463.2743124 1.0 1.3220305901602791 6.246320311938911 22.309529215188466 -6.920192566244532 0.8233043371188947 0.8921017071534338 7.043916061962726 0.9942341162107192 0.18230383573837156 0.09805850249967947 0.1050303427350897 0.15723377867308874 0.4718553717038723 1.201731468537199e-07 6.920192566244532 6.151814354809292 up ANAHFILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANAHFILK 8 0 O95071;E7EMW7;O95071-2;H0YAV7;H0YBB4 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 0 8715500.0 2907300.0 2148300.0 3659900.0 False True 3811498.4543332504 1827782.014007813 3281208.6562397946 1.0 0.47954420968735484 0.8608710446961941 21.861926860384465 -10.282177177134715 5.877537028188525 1.0000199163349694 0.670207627191777 0.4993237387183401 0.15567602850035941 4.063078709679061e-05 4.962223535744717e-06 0.15074175801719186 0.050244222148799506 5.221831128804556e-11 10.282177177134715 -0.3298122891431925 ANAHFILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANAHFILK 8 0 O95071;E7EMW7;O95071-2;H0YAV7;H0YBB4 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 0 5919200.0 2907300.0 1005100.0 2006800.0 False True 3982207.3768283254 960691.3585787723 1532835.1713433508 1.0 0.2412459391665147 0.38492098132875113 21.925136921907356 -9.947739949031366 6.842467531436358 1.000000043335976 0.31308346031534956 0.9682316072829783 0.058655090345069646 3.88779448900954e-08 5.936630433201083e-09 0.05679255125052809 0.01893084900639357 1.1278726122764431e-10 9.947739949031366 -0.6869165830206263 ANAHFILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANAHFILK 8 0 O95071;E7EMW7;O95071-2;H0YAV7;H0YBB4 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 0 2771400.0 896780.0 892530.0 982090.0 False True 745712.3040900799 887721.763736667 1187440.478328892 1.0 1.190434647340126 1.5923573633102515 19.508259620310294 -6.958979299373499 0.44959258315654366 0.9869847209390076 1.8117297747824803 0.9997304352423702 0.00405391980411676 0.0800678373465993 0.022494335909428217 0.0053688566436545125 0.033247634496904155 1.0990582247437624e-07 6.958979299373499 0.8247450538434727 ANATAK(ub)ATVAAFAASEGHSHPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANATAKATVAAFAASEGHSHPR 22 1 Q9NUP9 Q9NUP9 LIN7C Protein lin-7 homolog C 1 19402400.0 7468900.0 6400000.0 5533500.0 True False 11330867.349730449 5257869.996571768 4439801.299580788 1.0 0.4640306725236571 0.3918324310527214 23.4337549643162 -13.999999999999998 0.28250560379664164 5.428989663866974 0.3706290616828629 0.99961073522913 0.005352327532097369 15.535409974450484 0.1684112068477124 39.81257668770611 0.028224068985960717 1.0000000000000041e-14 13.999999999999998 -5.058360602184111 ANCIDSTASAEAVFASEVK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANCIDSTASAEAVFASEVKK 20 1 P22087;M0R299;M0QXL5;M0R2Q4 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 8542200.0 2510300.0 3251700.0 2780200.0 True False 3291027.6097797835 2766559.035027328 2492531.573561544 1.0 0.8406368353781298 0.7573718209335624 21.65010669919734 -13.999999999999295 0.08195991521941869 1.8494870964745223 0.517494652146962 0.9998784567154668 0.0011097656595965304 12.23923501600069 0.08111547645739357 1.8685939534081875 0.21733232970886893 1.0000000000016238e-14 13.999999999999295 -1.3319924443275601 ANCIDSTASAEAVFASEVK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANCIDSTASAEAVFASEVKK 20 1 P22087;M0R299;M0QXL5;M0R2Q4 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 9833500.0 2510300.0 2445100.0 4878100.0 True False 3438425.748306729 2337067.3971355655 3725993.247623084 1.0 0.6796911052351404 1.0836334765867692 21.713316760720232 -6.695341490844898 1.847050488167243 0.8002099396859231 1.0823510910746574 0.39576571412364536 0.13532349010405204 0.40525714061898005 2.6844219017547943 0.05851740803049408 0.1513869966250747 2.016779922337127e-07 6.695341490844898 0.2821411513887343 ANDDIIVNWVNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANDDIIVNWVNR 12 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 13010100.0 2564400.0 4777900.0 5667800.0 False True 3361953.2336849226 4065055.9441083265 5081350.425376628 1.0 1.2091351846833267 1.5114280515458367 21.680868225486563 -6.9658658759750045 0.342871272216736 0.9682835993177159 1.7623694791940678 0.9999298924945785 0.0017578315491697557 0.07766839323193282 0.013830984888800985 0.004230878109908083 0.02611053476627665 1.081767984264346e-07 6.9658658759750045 0.7940858798763519 ANDDIIVNWVNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANDDIIVNWVNR 12 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 10580300.0 2998000.0 1009300.0 6573000.0 False True 2902830.131022231 1412318.7534299672 4851334.114226771 1.0 0.4865316569291016 1.6712428544753923 21.46902871955185 -6.788890249913612 1.5005935161238264 0.7126138303900461 1.6834948673263592 0.7977823181889925 0.21813552815604578 0.23699639684604612 1.0542647589881018 0.11442410921279404 0.26813265059728225 1.625959598318973e-07 6.788890249913612 0.9708810369363131 ANDDIIVNWVNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANDDIIVNWVNR 12 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 13110600.0 2564400.0 4968300.0 5577900.0 False True 3512527.98030425 4748784.078028965 4260514.900456486 1.0 1.3519562277245212 1.2129483165248542 21.744078287009454 -10.219214130143893 5.372779312016132 0.9999819716947006 1.282452272124727 0.8462698574559204 0.05674974210835411 1.2255993541708017e-05 1.7809624896923147e-06 0.05495120582104405 0.01831590050724855 6.036509241651677e-11 10.219214130143893 0.2824703004300263 ANDIEK(ub)AVQSLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANDIEKAVQSLDK 13 1 O15511;B1ALC0;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 6685700.0 1577500.0 1658000.0 3450200.0 True False 1311761.145099246 1649068.024912767 4171620.8680776167 1.0 1.2571404718562547 3.180168038718663 20.32307361690818 -6.931373277483091 0.7354373683629295 0.9721954517301722 3.589119380698597 0.996801241457534 0.05501994628172272 0.09193108676015274 0.07423401043006997 0.05054153581544145 0.17270570791147846 1.1711882927709091e-07 6.931373277483091 2.6169239289684247 up ANDQEPCGWWLAK(ub)VR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANDQEPCGWWLAKVR 15 1 B4DXZ6;P51114;P51114-2;E9PFF5;C9JAJ4 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 9368500.0 2681700.0 3142200.0 3544600.0 True False 3515734.669619745 2673396.0081996694 3177838.794204104 1.0 0.7604089214413949 0.9038903935682419 21.745394764587083 -10.274510020264904 5.242588923833099 1.000026392196234 0.8321496576126307 0.6459801441156554 0.05857606570910525 1.807223201559672e-05 2.500923783436991e-06 0.05672494371496254 0.018905343914797902 5.314837366999724e-11 10.274510020264904 -0.1678767345836033 ANDQEPCGWWLAK(ub)VR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANDQEPCGWWLAKVR 15 1 B4DXZ6;P51114;P51114-2;E9PFF5;C9JAJ4 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 7973600.0 2681700.0 2648700.0 2643200.0 True False 3673196.9602175658 2531671.675920397 2018930.5984127705 1.0 0.6892284033063244 0.5496385356621846 21.808604826109974 -13.999999999968255 0.10813191335731301 2.5046960531834954 0.2865394113247958 0.9997525573258621 0.002960980248465407 12.023939536062088 0.09947403195306113 3.9641037065041163 0.2338084748047842 1.0000000000730962e-14 13.999999999968255 -2.2181566418586995 ANDTTFGLAAGVFTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANDTTFGLAAGVFTR 15 0 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 8966500.0 2328700.0 3894500.0 2743300.0 False True 3052948.2511628806 3313455.7806421 2459449.6315917475 1.0 1.0853298215520002 0.8055982051628071 21.541771704750484 -6.8248454379199215 1.350744622092836 1.0457811805763064 0.7988311953609414 0.8951732168697232 0.037899801408902235 0.18725977869871835 0.6699677908883817 0.022040949948682474 0.05074820961023746 1.4967682496729293e-07 6.8248454379199215 -0.24694998521536504 ANDTTFGLAAGVFTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANDTTFGLAAGVFTR 15 0 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 13281500.0 5257400.0 1699200.0 6324900.0 False True 5090506.71475526 2377699.4212109395 4668218.9470672235 1.0 0.46708501814151004 0.9170440603753649 22.279377840257627 -10.137072202054984 7.617428040851542 1.000000082256324 0.692064539258439 0.3844149341393016 0.18369500977072836 2.5661444909527137e-07 2.887839636774845e-08 0.1778619761117811 0.059287309468619986 7.293362470204964e-11 10.137072202054984 -0.30793554299788495 ANDTTFGLAAGVFTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANDTTFGLAAGVFTR 15 0 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 6856100.0 2328700.0 0.0 4527400.0 False True 3189683.320751255 0.0 3458121.3647298566 1.0 0.0 1.0841582116419561 21.604981766273376 -10.885961332415365 5.1021671698365445 1.119935048276585 0.542079105820978 0.19215881790563194 0.44260573649518803 0.25576923375062866 0.005716701421022224 0.1815229626448346 0.14285038719847756 1.3002853443104638e-11 10.885961332415365 -0.5778559424556071 ANDTTFGLAAGVFTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANDTTFGLAAGVFTR 15 0 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 6988900.0 5257400.0 1731500.0 0.0 False True 4371761.0423104735 1722172.0658241592 0.0 1.0 0.3939309695010211 0.0 22.059783115691904 -8.30560191093849 0.5340078363103098 1.034228389044981 1.2966479899142451e-16 0.9920549302128895 0.03666117930261894 0.1526132192285667 0.17713088629389 0.060653286301306605 0.07095660456306124 4.9476399666657646e-09 8.30560191093849 -1.0342283890449808 ANECK(ub)TGFCHLYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANECKTGFCHLYK 13 1 Q86TI2-4;Q86TI2;Q86TI2-2;M0R2A8 Q86TI2-4 DPP9 Dipeptidyl peptidase 9 1 8061200.0 1124400.0 1859000.0 5077800.0 True False 1455557.9652375635 1755545.0158076633 4153692.5026278184 1.0 1.2060976324780983 2.8536771477526757 20.473140862921312 -6.930109587130867 0.7458951690223211 0.9750471437620701 3.1928591718684234 0.9965597019810994 0.048655427552667684 0.09258091637411504 0.07740246661005794 0.044356382413538654 0.1489877268012939 1.17460112610058e-07 6.930109587130867 2.217812028106353 up ANEPCTSFAECVCDENCEK(ub)EALYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANEPCTSFAECVCDENCEKEALYK 24 1 Q13772;Q13772-3;Q13772-4;B4DF87;B4DZ85 Q13772 NCOA4 Nuclear receptor coactivator 4 1 126076300.0 4750300.0 22617000.0 98709000.0 True False 7206552.393448107 18580819.642572436 79199122.88430841 1.0 2.578322979996001 10.989876789949228 22.78087781014581 -6.9383925977365895 0.6743528285929878 0.9024425447561517 13.154809990670135 0.9979456697273835 0.19874255551278847 0.08850773257989132 0.058007116424862296 0.1911810481327906 0.7292422784311784 1.1524110191189186e-07 6.9383925977365895 12.252367445913983 ANEPCTSFAECVCDENCEK(ub)EALYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANEPCTSFAECVCDENCEKEALYK 24 1 Q13772;Q13772-3;Q13772-4;B4DF87;B4DZ85 Q13772 NCOA4 Nuclear receptor coactivator 4 1 111718300.0 4750300.0 11934000.0 95034000.0 True False 6149356.99241196 11269862.4091709 77738787.13118519 1.0 1.8326895678812307 12.641774941203037 22.55200413223826 -6.922290785439404 0.807546503350931 0.7806189706088037 14.480164931465742 0.9947941057177317 0.38259448309183636 0.09684270925538183 0.0987642376286929 0.3337076694366673 1.0226080749739337 1.195939512044097e-07 6.922290785439404 13.699545960856938 up ANFSLPEK(ub)CDYMDEVTYGELEKEEAQPIVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANFSLPEKCDYMDEVTYGELEKEEAQPIVTK 31 2 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 76341000.0 18625000.0 37824000.0 19892000.0 True False 28255486.66988843 31074011.67973916 15960337.481026683 1.0 1.0997514232467425 0.5648579926260993 24.752027702460133 -6.8585087133128075 1.193192343357705 1.053924867564163 0.5396778551900847 0.951802020711698 0.05098559250400806 0.14835338146623234 0.4021852652449095 0.033346048399015 0.07771645084583252 1.3851323955347196e-07 6.8585087133128075 -0.5142470123740783 ANFSLPEK(ub)CDYMDEVTYGELEKEEAQPIVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANFSLPEKCDYMDEVTYGELEKEEAQPIVTK 31 2 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 67236000.0 18625000.0 31565000.0 17046000.0 True False 24110429.653637193 29808380.002134964 13943802.906730033 1.0 1.2363272007323272 0.5783307517552485 24.523154024552582 -6.8095781626982905 1.4164317112106342 1.1288581882171853 0.5669424791764829 0.8587002274623518 0.10230266818001807 0.20737130071094836 0.8200882787985595 0.05679454222395157 0.13139505062024348 1.550321740569421e-07 6.8095781626982905 -0.5619157090407024 ANFWYQPSFHGVDLSALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANFWYQPSFHGVDLSALR 18 0 Q86X55-1;Q86X55;Q86X55-2;K7EQA8 Q86X55-1 CARM1 Histone-arginine methyltransferase CARM1 0 34999000.0 10356000.0 10353000.0 14290000.0 False True 10027254.448587792 14487006.890181784 10547020.309189176 1.0 1.4447630669452185 1.051835311776155 23.2574233015041 -10.402457271260607 6.31997461754706 0.9999584548414434 1.2482991893606867 0.34744237963609426 0.1604120843235736 9.391760575411377e-05 8.879842828755136e-06 0.15534426411290062 0.051772777592968354 3.958610103222329e-11 10.402457271260607 0.24834073451924332 ANFWYQPSFHGVDLSALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANFWYQPSFHGVDLSALR 18 0 Q86X55-1;Q86X55;Q86X55-2;K7EQA8 Q86X55-1 CARM1 Histone-arginine methyltransferase CARM1 0 15557600.0 1973700.0 2921900.0 10662000.0 False True 2703430.2272369806 2792800.7965688137 8143855.190782748 1.0 1.033058211908496 3.012415526294574 21.366359691744396 -6.91052676642931 0.8921411997217055 0.9397315166369048 3.2711163767989286 0.9911188137547962 0.08867674199596866 0.10407067170960976 0.13688588040971783 0.07279045907164805 0.2016752244975793 1.2287774522559608e-07 6.91052676642931 2.3313848601620237 up ANFWYQPSFHGVDLSALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANFWYQPSFHGVDLSALR 18 0 Q86X55-1;Q86X55;Q86X55-2;K7EQA8 Q86X55-1 CARM1 Histone-arginine methyltransferase CARM1 0 26922800.0 10356000.0 6919700.0 9647100.0 False True 8611472.848588133 6882422.202647095 11664264.006849328 1.0 0.7992154563635976 1.354502790862507 23.037828576938377 -6.8089188834870775 1.4193621284188076 0.890434261896174 1.3639519313724007 0.8569073440281552 0.08684164217884303 0.20828463282793608 0.8272586390723456 0.048114796436709746 0.11134000763474312 1.552676988271992e-07 6.8089188834870775 0.47351766947622664 ANGTTVHVGIHPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANGTTVHVGIHPSK 14 0 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 215297310.0 71938610.0 66311300.0 77047400.0 False True 94312214.36449032 56417912.51942285 69075274.13884819 1.0 0.5982036674632981 0.732410691492107 26.490941290487758 -10.35774161134242 4.971988022908761 1.0002144595450806 0.6653071794776279 0.892385349505356 0.05478978812826276 0.00013033235404848485 1.6835810812207628e-05 0.05308365214108757 0.01768332808021252 4.3879168445034975e-11 10.35774161134242 -0.33490728006745274 ANGTTVHVGIHPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANGTTVHVGIHPSK 14 0 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 107298900.0 26552000.0 17219000.0 63527900.0 False True 25709121.293829963 24094636.495898765 46888037.19385158 1.0 0.9372018677931764 1.8237899560225124 24.61577696568229 -6.889897459723589 1.0230222930315307 0.9522451664535769 1.8998823324429153 0.9808313844128521 0.05592778810326084 0.11922506318932319 0.22235033172521837 0.04166178686539879 0.1038219989668367 1.288553753257888e-07 6.889897459723589 0.9476371659893383 ANGTTVHVGIHPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANGTTVHVGIHPSK 14 0 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 138380400.0 41890400.0 59805000.0 36685000.0 False True 63550799.398458764 49132330.491402216 29434193.67039331 1.0 0.7731190001772625 0.4631600853018876 25.921406937056855 -6.966763686443504 0.3263694763592016 1.0393976848250592 0.18678922897649614 0.9999450194774876 0.001631539027099758 0.07736746159930967 0.012776452896576768 0.004583164229341059 0.027115895712040605 1.0795339715019618e-07 6.966763686443504 -0.8526084558485632 down ANGTTVHVGIHPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANGTTVHVGIHPSK 14 0 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 147779610.0 71938610.0 30301000.0 45540000.0 False True 98536258.18483685 28962201.627992574 34784389.925740555 1.0 0.2939243093000805 0.353011069899682 26.55415135201065 -10.380097528111403 5.147714764368973 1.0004357199406664 0.32346768959983685 0.9943116398221385 0.024122069003989517 0.00012069965562061977 1.4534988636829657e-05 0.023370503516449183 0.007785364294020895 4.167757789677239e-11 10.380097528111403 -0.6769680303408295 ANGTTVHVGIHPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANGTTVHVGIHPSK 14 0 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 78682000.0 26552000.0 29758000.0 22372000.0 False True 22079164.453042887 29597687.747499485 27049881.763559356 1.0 1.340525716471142 1.225131585984062 24.396182241116566 -10.231817208990211 4.580796309540464 0.9999143687783838 1.282828651229616 0.8890089326170884 0.04710945650781803 4.121127357581851e-05 6.910929554484705e-06 0.045627307223276466 0.015204511707665633 5.863849172174099e-11 10.231817208990211 0.2829142824512323 ANGTTVHVGIHPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANGTTVHVGIHPSK 14 0 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 138922500.0 41890400.0 56293100.0 40739000.0 False True 54227948.58323348 53160339.49938817 33324920.017439578 1.0 0.9803125673801462 0.6145340343511201 25.692533259149304 -6.918023392790698 0.8392544117536735 1.0086598908435083 0.5581494447653496 0.9936140332425066 0.014164631407834784 0.09934889813651296 0.11174322335638823 0.01207822043686573 0.03552385026917015 1.207748779305939e-07 6.918023392790698 -0.4505104460781587 ANHEEVLAAGK(ub)QAAQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANHEEVLAAGKQAAQK 16 1 P00491 P00491 PNP Purine nucleoside phosphorylase 1 32778800.0 3324400.0 4376400.0 25078000.0 True False 5043357.8461947385 3595397.227030734 20121322.307922147 1.0 0.7128975053284183 3.9896677811795325 22.265953163172785 -6.885556248751963 1.0483511134739834 0.8047249538503319 4.248097092312657 0.977896751053047 0.22028032444995366 0.12282107743203265 0.2435227450757657 0.16096692952634126 0.39536852317402754 1.3014987377506831e-07 6.885556248751963 3.443372138462325 up ANHEEVLAAGK(ub)QAAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANHEEVLAAGKQAAQK 16 1 P00491 P00491 PNP Purine nucleoside phosphorylase 1 4576200.0 1017500.0 1677700.0 1881000.0 True False 846096.3328928575 1668661.8971026253 2274308.403238652 1.0 1.9721890194197669 2.6880017260713633 19.690462406191877 -7.577243227881228 0.14921645495016503 5.198897842374236e-13 4.245421050708734 0.999981384622424 0.0029846657670313877 0.138019862162494 0.015436564791098763 0.1546516565211073 0.25034703411532655 2.647017253726341e-08 7.577243227881228 4.245421050708215 ANHEEVLAAGK(ub)QAAQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANHEEVLAAGKQAAQK 16 1 P00491 P00491 PNP Purine nucleoside phosphorylase 1 36889800.0 3324400.0 3061400.0 30504000.0 True False 4303501.333720881 2891030.3988131187 24952584.997471135 1.0 0.6717856402552767 5.798205475609021 22.037079485265235 -6.891628386126399 1.012734076499636 0.7352067366729018 6.253396158349505 0.9819190677303935 0.31506457403227744 0.11783056052103452 0.21422621130880704 0.23653048323775985 0.5932188064051982 1.2834283073352314e-07 6.891628386126399 5.5181894216766025 up ANHFLILFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANHFLILFR 9 0 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 0 3458700.0 1046100.0 1347000.0 1065600.0 False True 1371447.2304468104 1146032.8505648768 955341.9339569751 1.0 0.8356375842412145 0.6965940159766334 20.387267681603458 -6.9730621816001985 0.16980417099274306 1.1231722964368718 0.4053364639737977 0.9999974725938418 0.00019706213785112143 0.07532112621376356 0.0052954857089154385 0.005870219216859727 0.016119971173269416 1.0639906668092511e-07 6.9730621816001985 -0.717835832463074 ANHFLILFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANHFLILFR 9 0 Q9P1Y5;Q9P1Y5-2 Q9P1Y5 CAMSAP3 Calmodulin-regulated spectrin-associated protein 3 0 4440600.0 1046100.0 1723900.0 1670600.0 False True 1432871.4397895331 1647732.3978250376 1276038.6870870064 1.0 1.149951315986216 0.8905465289156974 20.45047774312635 -6.7499496536642525 1.6498257416776705 1.0881772150407683 0.8900264780262805 0.6488369528417395 0.06301062807457862 0.30013373118107284 1.6072822031605403 0.030169223205876422 0.07325249096956146 1.7784855720916618e-07 6.7499496536642525 -0.1981507370144877 ANHSFTPNCIYDMFVHPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANHSFTPNCIYDMFVHPR 18 0 Q8WTS6 Q8WTS6 SETD7 Histone-lysine N-methyltransferase SETD7 0 4222390.0 918790.0 1163900.0 2139700.0 False True 1204542.5875750177 990250.6568466666 1918304.3694517033 1.0 0.8220968416237046 1.592558361355765 20.200053971449435 -6.8459270811869155 1.2545273036161955 0.9052974170812169 1.621031299611597 0.9341762225648212 0.08450470585885224 0.16199266248930153 0.49265618357320234 0.05275898521390157 0.12181552483702818 1.4258469757391209e-07 6.8459270811869155 0.7157338825303801 ANHSFTPNCIYDMFVHPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANHSFTPNCIYDMFVHPR 18 0 Q8WTS6 Q8WTS6 SETD7 Histone-lysine N-methyltransferase SETD7 0 6338090.0 918790.0 2075700.0 3343600.0 False True 1258491.4923661472 1983988.7105780072 2553910.5436035595 1.0 1.5764816231278764 2.0293427163355995 20.263264032972327 -6.973836461054388 0.1386916545295219 0.38194453542659595 3.235679826718002 0.9999989676023284 0.0004279665701380448 0.07507630657150405 0.004195151603767323 0.025950777282561347 0.059330344440360144 1.0620954270435327e-07 6.973836461054388 2.853735291291406 ANINVENAFFTLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANINVENAFFTLAR 14 0 P61006 P61006 RAB8A Ras-related protein Rab-8A 0 6252800.0 3408600.0 1562000.0 1282200.0 False True 4468707.60892936 1328955.6886283122 1149530.243730885 1.0 0.2973915066568232 0.2572399772663346 22.091426220468446 -13.635771143671718 0.4106420999525481 9.99992560482089 0.25541733514282144 0.9998461454264578 0.004230573782859074 20.781876670853126 0.21205855197785453 165.41393171617116 0.009985682008741281 2.313283479615206e-14 13.635771143671718 -9.744508269678068 ANINVENAFFTLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANINVENAFFTLAR 14 0 P61006 P61006 RAB8A Ras-related protein Rab-8A 0 6497100.0 3408600.0 1286200.0 1802300.0 False True 4668851.533951447 1229371.4311053779 1376633.8595336452 1.0 0.2633134556036972 0.2948549229982778 22.154636281991337 -10.695094699230665 6.756043922093022 1.0062795846781307 0.2790841893010527 0.9985663835367473 0.01287675014255922 0.0012169332809349206 5.492102941640666e-05 0.012457392378327777 0.004155953237950487 2.017926300746761e-11 10.695094699230665 -0.727195395377078 ANITAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANITAIR 7 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 4643050.0 1475100.0 452750.0 2715200.0 False True 1428273.757928919 633535.4360600595 2004007.6657460113 1.0 0.4435672311019164 1.403097728723897 20.445841097258402 -6.749489442847617 1.6517858374677026 0.6726103377451493 1.4049247228691206 0.6467506002186905 0.23381074258489556 0.30093636208704005 1.6153148972438773 0.11182751637378124 0.2716271755304005 1.7803711869110252e-07 6.749489442847617 0.7323143851239713 ANIVHLMLSSPEQIQK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ANIVHLMLSSPEQIQK 16 0 P55060-3;P55060;P55060-4;P55060-2 P55060-3 CSE1L Exportin-2 0 88868200.0 31847300.0 27452300.0 29568600.0 False True 41752118.70969188 23356523.848227262 26509124.914039217 1.0 0.5594093083186586 0.6349168792693071 25.315346073161326 -10.747033922210964 6.956329869898083 1.007005090368965 0.5971630937941547 0.9743263151421895 0.03082583675768106 0.0033648385250901027 0.00012236177078244568 0.029988453089776716 0.009948996032950592 1.7904659974635178e-11 10.747033922210964 -0.40984199657481024 ANIVHLMLSSPEQIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANIVHLMLSSPEQIQK 16 0 P55060-3;P55060;P55060-4;P55060-2 P55060-3 CSE1L Exportin-2 0 48922000.0 17084000.0 10337000.0 21501000.0 False True 16541677.771308811 14464618.006742876 15869243.083826222 1.0 0.8744347584760386 0.9593490638144994 23.979602234246133 -10.187895879557221 5.245503292639655 1.000004568235208 0.9168919111452366 0.5608668752156986 0.034666119990466315 1.852094645334449e-06 2.867510279037331e-07 0.03356717094276318 0.011188442116709033 6.487899598181906e-11 10.187895879557221 -0.08311265708997129 ANIVHLMLSSPEQIQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANIVHLMLSSPEQIQK 16 0 P55060-3;P55060;P55060-4;P55060-2 P55060-3 CSE1L Exportin-2 0 97348000.0 18609000.0 44888000.0 33851000.0 False True 28231213.50013172 36877385.68845527 27160335.01257964 1.0 1.306262860017803 0.9620675715003507 24.750787807628793 -6.67193453818124 1.9300624891123697 1.195150892059765 0.9634308415432834 0.2878999042330165 0.13003427287515903 0.45665330893002093 3.2812471896544255 0.05419795531344644 0.1444629268925338 2.1284598475544393e-07 6.67193453818124 -0.2317200505164817 ANIVHLMLSSPEQIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANIVHLMLSSPEQIQK 16 0 P55060-3;P55060;P55060-4;P55060-2 P55060-3 CSE1L Exportin-2 0 18736800.0 5059300.0 6771900.0 6905600.0 False True 6929859.932441631 6472695.066321343 5274639.505296312 1.0 0.9340297104736411 0.7611466258651887 22.72439476197324 -6.9544440721560035 0.5077170772589216 1.003242459995022 0.6843786835214605 0.9995054625155528 0.002239712424328531 0.08174878426555571 0.02894551070017769 0.0025899936837346887 0.014266405919444539 1.1105955470868016e-07 6.9544440721560035 -0.31886377647356157 ANIVHLMLSSPEQIQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANIVHLMLSSPEQIQK 16 0 P55060-3;P55060;P55060-4;P55060-2 P55060-3 CSE1L Exportin-2 0 70780000.0 18609000.0 28935000.0 23236000.0 False True 24089717.338230018 27324741.814090785 19007286.421493538 1.0 1.1342906780698017 0.7890207325649795 24.521914129721242 -6.801214067864911 1.4508265445246422 1.0739795296160979 0.7841032122580985 0.835735196891117 0.05759665466206121 0.21902077175115428 0.9100102836614389 0.031228658187838192 0.07257734301869591 1.5804688191883395e-07 6.801214067864911 -0.28987631735799935 ANK(ub)ITITNDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANKITITNDK 10 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 1 27553900.0 14265700.0 10542000.0 2746200.0 True False 18702470.849235307 8969174.692394149 2462049.5674105133 1.0 0.4795716440194785 0.13164301055500266 24.15672554643444 -8.276208524046773 0.34875891895163463 1.110831746741835 3.239566541352669e-21 0.998156163754629 0.015322215320781598 0.10768703809674476 0.0880690600713918 0.07896439120006432 0.08827640983198307 5.294091900196781e-09 8.276208524046773 -1.110831746741835 ANK(ub)ITITNDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANKITITNDK 10 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 1 26500200.0 14265700.0 8959400.0 3275100.0 True False 19540114.80604678 8563544.0832262 2501588.8328017765 1.0 0.4382545429352427 0.12802324129782738 24.219935607957332 -8.643421498315153 0.3181279056858874 1.1768983436112095 4.033321677171515e-19 0.9984367303251986 0.01426876252682628 0.24288875320475511 0.09615746733692115 0.1396443619023486 0.09264742074427948 2.272890438565553e-09 8.643421498315153 -1.1768983436112095 ANK(ub)ITITNDK(ub)GR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANKITITNDKGR 12 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 2 7973500.0 3614900.0 2858500.0 1500100.0 True False 4739168.9067414 2432022.942345731 1344884.0419752775 1.0 0.5131749870502005 0.2837805675299311 22.176202649702933 -10.4729778621494 0.1611684033197462 1.821691632595369 3.386270632638957e-22 0.9996304180232308 0.005740913069754588 2.2456016752843184 0.08327127644050313 0.9202260503511589 0.18685485579844316 3.365287232492608e-11 10.4729778621494 -1.821691632595369 ANK(ub)ITITNDK(ub)GR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANKITITNDKGR 12 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 2 10915800.0 2962200.0 4698600.0 3255000.0 True False 2868166.5824263026 6574775.482875305 2402417.8520931248 1.0 2.2923269252071914 0.8376144770715579 21.451697387178882 -6.672297251412969 1.9289541795697025 1.8232309578108987 0.8433927272086026 0.2894096769928073 0.5486593498382736 0.45584639562965634 3.272080213470296 0.2287925147403519 0.6095122273491596 2.1266829466623518e-07 6.672297251412969 -0.9798382306022961 ANK(ub)ITITNDK(ub)GR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANKITITNDKGR 12 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 2 24859200.0 9603400.0 9070500.0 6185300.0 True False 14569059.902582902 7451798.4068600265 4962772.743886708 1.0 0.5114810740491856 0.3406378158282453 23.796404451865246 -13.999999999999998 0.14647586851917552 3.350318675710311 0.14484162587964486 0.9995784249678253 0.005736790676316666 11.946223024117542 0.12034087626923505 8.000841066720957 0.17591159331292006 1.0000000000000041e-14 13.999999999999998 -3.205477049830666 ANK(ub)ITITNDK(ub)GR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANKITITNDKGR 12 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 2 8029000.0 3614900.0 2939700.0 1474400.0 True False 4951426.21899932 2809814.333712087 1126177.0862211671 1.0 0.567475755355181 0.22744498986976056 22.239412711225825 -7.927626498148788 0.2945159135858647 1.1234567470708778 1.0394212034963093e-11 0.9993176239742741 0.008258489317968347 0.10696379355613832 0.05271856736963109 0.05300144698471909 0.0882686935869027 1.1813361713904336e-08 7.927626498148788 -1.1234567470604837 down ANK(ub)ITITNDK(ub)GR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANKITITNDKGR 12 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 2 9563600.0 2962200.0 5401000.0 1200400.0 True False 2463200.5477102934 5371903.740985432 1451398.0899774989 1.0 2.1808633267717354 0.5892326109324183 21.23210266261316 -6.7079852207740345 1.8022264904163092 1.727439621754706 0.5931594807628157 0.45564083547559653 0.49776651961112944 0.37911901210103 2.3990691158995157 0.21989172712599694 0.560030985320215 1.9589113349577627e-07 6.7079852207740345 -1.1342801409918901 ANK(ub)ITITNDK(ub)GR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANKITITNDKGR 12 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 2 19174300.0 9603400.0 6792900.0 2778000.0 True False 12431790.611314869 6414869.143561003 2272432.5046870834 1.0 0.5160052436631671 0.18279205109992888 23.567530773957696 -8.215804789106569 0.3052203482968212 1.1401802965696242 1.2185285993115106e-22 0.9989180812535933 0.011035816707538988 0.09368238364934468 0.07036613143487207 0.08029510456422863 0.09412317092903498 6.084084131371724e-09 8.215804789106569 -1.1401802965696242 down ANK(ub)LDHVVTIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANKLDHVVTIIK 12 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;Q99873-5;E9PNR9;H0YDE4 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 15754200.0 3569500.0 6017800.0 6166900.0 True False 4679649.067087175 5119967.69720068 5528808.345081893 1.0 1.0940922329433516 1.181457896910905 22.157968913629396 -6.972017041269734 0.20435419322883583 0.950831852816153 1.3271419030994185 0.9999941278022337 0.00017946319821986065 0.07565352411889736 0.006634074007633681 0.00273739457701316 0.0091752767482071 1.0665542699142619e-07 6.972017041269734 0.3763100502832655 ANK(ub)LDHVVTIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANKLDHVVTIIK 12 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;Q99873-5;E9PNR9;H0YDE4 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 29633800.0 3839000.0 8005800.0 17789000.0 True False 3717133.0463623614 11202557.68969546 13129527.241439221 1.0 3.013762905435532 3.532164998583508 21.825758896450942 -9.814113125222425 0.3527759238808427 1.0541706048649425e-24 3.6429276202828578 0.99868888736622 0.03954729507259953 1.1622493158537506 0.15281597587167903 1.425025834159558 0.15126103896948112 1.534217297133224e-10 9.814113125222425 3.6429276202828578 ANK(ub)LDHVVTIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANKLDHVVTIIK 12 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;Q99873-5;E9PNR9;H0YDE4 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 40099100.0 5833800.0 9696300.0 24569000.0 True False 8850301.107908456 7965919.507462309 19712926.381024778 1.0 0.9000732755119618 2.2273735255639715 23.077295109208674 -6.888754713972486 1.029747376518981 0.9265386827873985 2.3387758556150633 0.9800882374284904 0.0851625146161202 0.12015826568939904 0.22780916476706156 0.06311675869456185 0.15665814989065496 1.2919487498473282e-07 6.888754713972486 1.4122371728276648 up ANK(ub)LDHVVTIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANKLDHVVTIIK 12 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;Q99873-5;E9PNR9;H0YDE4 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 22010100.0 3569500.0 3043600.0 15397000.0 True False 4889240.612110452 2909123.688160733 11760545.711168822 1.0 0.5950052204334045 2.4053931160676414 22.221178975152288 -6.847972221066223 1.2447413483517156 0.7841856964202429 2.475018913051194 0.9373112760946798 0.19424016753742335 0.15970596499515055 0.47717566382740595 0.12216470869887104 0.28237059563929306 1.419148292277496e-07 6.847972221066223 1.6908332166309512 up ANK(ub)LDHVVTIIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANKLDHVVTIIK 12 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;Q99873-5;E9PNR9;H0YDE4 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 20077900.0 3839000.0 7692900.0 8546000.0 True False 3192298.5965362987 7651456.820778911 10332929.08776051 1.0 2.3968487249535113 3.236830382650271 21.60616417188522 -8.622747799246788 0.20746886795227248 1.5440964187194735e-21 4.135998928175819 0.9996179611661604 0.01803231812796259 0.22218478401202785 0.05790220335506198 0.5443679837943146 0.4055348694437979 2.3837033166705586e-09 8.622747799246788 4.135998928175819 ANK(ub)LDHVVTIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANKLDHVVTIIK 12 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;Q99873-5;E9PNR9;H0YDE4 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 32862200.0 5833800.0 9685400.0 17343000.0 True False 7551969.101389989 9146398.975849157 14186751.954207366 1.0 1.2111277010079005 1.8785500528062544 22.848421431301123 -6.950268266139918 0.5558914833518418 0.9910759677340918 2.1302747926595225 0.9992221623108383 0.010443156888335114 0.08337821952595736 0.03551805475458758 0.011250847090839731 0.05543268647161917 1.1213255912176485e-07 6.950268266139918 1.1391988249254306 ANK(ub)QSSVLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANKQSSVLER 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 15601300.0 5367900.0 6057300.0 4176100.0 True False 7037368.88281754 5153574.451170466 3743997.2319798456 1.0 0.7323155197610073 0.5320166235880003 22.746604707103742 -7.285026801755614 0.13271148063753532 1.3212958608121017 2.982406115165389e-12 0.9999966958958232 0.00034843168023339984 0.10598151836427891 0.007404948934734346 0.024971478319575455 0.04568199408984527 5.187680230425293e-08 7.285026801755614 -1.3212958608091192 ANK(ub)QSSVLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANKQSSVLER 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 19767200.0 6512200.0 7526500.0 5728500.0 True False 6305473.775598056 10531870.700178983 4228033.998683709 1.0 1.6702742846916472 0.6705339121456725 22.588173344005586 -6.726055941443052 1.7374823240871589 1.4051424374499755 0.6715398901376348 0.5408414252686048 0.28186796834179756 0.34373652465865734 2.0310090817613453 0.12865300981055222 0.32069478245309807 1.8790747577204297e-07 6.726055941443052 -0.7336025473123406 ANK(ub)QSSVLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANKQSSVLER 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 13868800.0 5367900.0 4332600.0 4168300.0 True False 7352557.6920430465 4141171.4060077523 3183833.388833211 1.0 0.5632286857795535 0.43302392476005486 22.809814768626634 -13.999999999999998 0.16962102978515778 3.200473280757999 0.31770383595312635 0.999514406070418 0.005343411298256503 12.08786575323334 0.1304126056816971 8.75165061281979 0.10652180832393666 1.0000000000000041e-14 13.999999999999998 -2.8827694448048726 ANK(ub)QSSVLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANKQSSVLER 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 10653510.0 6512200.0 3364300.0 777010.0 True False 5415182.83937579 3346175.8481387384 939479.1985116776 1.0 0.6179248138783904 0.173489838917419 22.368578619439862 -7.547032342599573 0.4132885390645535 1.0353156604096085 4.805693755347184e-14 0.998583432753008 0.012711675009511718 0.11989790179790807 0.05456030964241221 0.02128471040491552 0.06918832949375742 2.8377076919752755e-08 7.547032342599573 -1.0353156604095606 down ANK(ub)QSSVLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANKQSSVLER 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 7253100.0 2199000.0 1962800.0 3091300.0 True False 2846648.84877037 1853568.4545601304 2528715.1194165563 1.0 0.6511405350754071 0.8883129791399641 21.4408331082833 -10.29521243544655 5.1902703553833485 1.000050606238581 0.7697267571076567 0.5569123657119207 0.0968252448346065 5.671282548925507e-05 7.700978826897823e-06 0.09377120905264347 0.031250213394724 5.067427740622265e-11 10.29521243544655 -0.2303238491309243 ANK(ub)TPLRPLDPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANKTPLRPLDPTR 13 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 8571580.0 1736530.0 1914550.0 4920500.0 True False 1681404.8056784645 2679039.7992463545 3631673.438164125 1.0 1.5933342108923816 2.159904281169642 20.681235670958078 -6.971686314159082 0.21411334667272175 0.7185002133698328 3.0506285463931375 0.9999927177454307 0.0012779491036704082 0.07575923230434128 0.007038103662022328 0.016424988514285446 0.05816433326330095 1.0673667894622062e-07 6.971686314159082 2.332128333023305 ANK(ub)TPLRPLDPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANKTPLRPLDPTR 13 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 7497260.0 1736530.0 3651100.0 2109630.0 True False 1444001.6363227854 3631430.7996133952 2550743.8791729687 1.0 2.514838424186967 1.7664411279121206 20.461640946392354 -10.34565931684867 5.408494028709485 0.9996702757918138 2.140639776049571 0.7559317676542318 0.30553191679207914 0.0012150764856862935 0.0001470039384748502 0.2959104628778942 0.09861000212253215 4.511704873271415e-11 10.34565931684867 1.1409695002577571 ANK(ub)TPLRPLDPTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANKTPLRPLDPTR 13 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 37481300.0 4452800.0 8578500.0 24450000.0 True False 5764237.377810237 8101098.933892442 20000350.878185466 1.0 1.4054068913050124 3.469730610883231 22.458698317872578 -6.939399277003592 0.665127569474879 0.9765715998768187 4.016713377743225 0.9980841687321688 0.04733428016199525 0.0880417389553298 0.05586547885398281 0.04586932735301472 0.17814761956900466 1.1497428646256891e-07 6.939399277003592 3.0401417778664066 up ANLGVFSVFAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANLGVFSVFAPR 12 0 A6NHR9-2;A6NHR9;J3KTL8;A6NHR9-3 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 0 13660800.0 3361700.0 4042500.0 6256600.0 False True 4407221.25474911 3439374.757541585 5609227.0495450515 1.0 0.7803953009700617 1.2727355232053963 22.071437895056096 -6.785493212515417 1.5147360024605139 0.8765385069857985 1.2773091497474325 0.7862452361791483 0.09310840749168629 0.24214099250694648 1.0976471760045705 0.04840073937182289 0.11367964557811157 1.63872767236734e-07 6.785493212515417 0.400770642761634 ANLGVFSVFAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANLGVFSVFAPR 12 0 A6NHR9-2;A6NHR9;J3KTL8;A6NHR9-3 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 0 8454700.0 3426900.0 1919900.0 3107900.0 False True 3318114.9352902235 2686526.0821462367 2293847.7549985363 1.0 0.8096543171465687 0.6913105180902668 21.661932429608715 -11.879023760914453 0.05320156180130399 2.1135357335535296 2.134511511736724e-05 0.9999839647976122 0.0005091646475670714 5.493842578916151 0.0401383884291141 1.2212013529621655 0.505780318283171 1.3212233460617753e-12 11.879023760914453 -2.1135143884384124 ANLGVFSVFAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANLGVFSVFAPR 12 0 A6NHR9-2;A6NHR9;J3KTL8;A6NHR9-3 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 0 12883400.0 3361700.0 4056100.0 5465600.0 False True 4604611.336526599 3876888.0902709733 4174737.8475653823 1.0 0.8419577260554265 0.9066428287766229 22.134647956578988 -10.336195291520985 4.8153073187098485 1.0000799663946094 0.8743002774190378 0.8342997054884329 0.026407582604696903 2.2685111288416214e-05 3.1271706253849044e-06 0.02558527827234487 0.008523010636757878 4.611101780549228e-11 10.336195291520985 -0.12577968897557157 ANLGVFSVFAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANLGVFSVFAPR 12 0 A6NHR9-2;A6NHR9;J3KTL8;A6NHR9-3 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 0 6767200.0 3426900.0 1113000.0 2227300.0 False True 2849619.1874108454 1107004.0480867967 2693018.1321283635 1.0 0.3884743803583864 0.9450449182914265 21.44233770504299 -10.577355161913285 9.322534922866035 1.0000382504298293 0.6667596493249096 0.32340274761119026 0.22721897063371624 0.00018066170681660802 8.19050366608413e-06 0.22002892531428483 0.07333460743389796 2.6463351056746183e-11 10.577355161913285 -0.3332786011049197 ANLLNNEAHAITMQVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANLLNNEAHAITMQVTK 17 0 P46063 P46063 RECQL ATP-dependent DNA helicase Q1 0 14717500.0 3025800.0 7219600.0 4472100.0 False True 3966853.1018888783 6142463.82178039 4009369.9914123355 1.0 1.5484475134346571 1.0107180398243667 21.919563542784076 -10.53682135925349 3.3334938702098635 0.9920148382966282 1.2795827767353487 0.2649431985876137 0.2195271387559429 103712722.55329226 81355267.09081309 7026376.950378616 0.08033866387429608 2.9052174278423838e-11 10.53682135925349 0.2875679384387205 ANLLNNEAHAITMQVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANLLNNEAHAITMQVTK 17 0 P46063 P46063 RECQL ATP-dependent DNA helicase Q1 0 13199800.0 3025800.0 4972600.0 5201400.0 False True 4144520.0291704102 4752894.089810764 3972936.4461955857 1.0 1.1467899916898532 0.9585998905139398 21.982773604306967 -6.69858873122946 1.835888356835417 1.0912787689251304 0.9591749173523157 0.4108069650040248 0.06197844863745014 0.3985097720638475 2.610321378166006 0.02694247844026348 0.06941027567261074 2.0017565985012286e-07 6.69858873122946 -0.13210385157281468 ANLQIDQINTDLNLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANLQIDQINTDLNLER 16 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 17265300.0 6795600.0 6560000.0 3909700.0 False True 8909097.408684012 5581273.5706797205 3505161.748490602 1.0 0.6264690253851593 0.39343623575986464 23.086847847314335 -8.711106934356252 0.1548896261886557 1.4416304202129737 4.767315831970223e-11 0.9998624893867285 0.0029296603269391573 0.2657456757746359 0.0433370143912998 0.20770215690383348 0.15469572638001747 1.9448811434179456e-09 8.711106934356252 -1.4416304201653005 ANLQIDQINTDLNLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANLQIDQINTDLNLER 16 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 34489200.0 12754000.0 6080200.0 15655000.0 False True 12349131.25118664 8508055.567824122 11554485.860066945 1.0 0.688959846224533 0.9356517171162679 23.557906217463646 -9.887912129150648 5.973077722011741 1.0000000427427411 0.8123057826988963 0.43561697267531696 0.10071153456328806 5.73119474742659e-08 1.070384150261635e-08 0.0975135458294143 0.032504508011157965 1.294457722726477e-10 9.887912129150648 -0.18769426004384482 ANLQIDQINTDLNLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANLQIDQINTDLNLER 16 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 83378100.0 4142400.0 70748000.0 8487700.0 False True 6284323.650005139 58122466.643353 6810102.374708934 1.0 9.248802238774807 1.0836651251568439 22.58332605234863 -6.643871288982909 2.0307601402285065 6.378587274215918 1.118170624112307 0.1693890492919431 3.526081311074119 0.5237769708370869 4.1330590930379545 1.4117610658894661 3.904091077857156 2.2705376670429933e-07 6.643871288982909 -5.260416650103611 ANLQIDQINTDLNLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANLQIDQINTDLNLER 16 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 40141600.0 6795600.0 10552000.0 22794000.0 False True 9308116.964184832 10085777.749202276 17410526.657165807 1.0 1.0835465205271568 1.8704671121083782 23.150057908837226 -6.927190235739066 0.7694964849802827 0.9867050714541056 2.0210407246638025 0.9959569362125591 0.02493401380225282 0.0941225696714268 0.08501831837450326 0.0223476076571904 0.07233353358942157 1.1825234568083878e-07 6.927190235739066 1.034335653209697 ANLQIDQINTDLNLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANLQIDQINTDLNLER 16 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 27808000.0 12754000.0 8836400.0 6217600.0 False True 10605516.098000498 8788796.559311925 7517671.413065734 1.0 0.8287005062364586 0.7088454105956307 23.338311492897923 -6.974953140687851 0.07339113206423042 1.4777561399547214 0.0567912740752751 0.999999927287427 3.1696641266655644e-05 0.07472607758653925 0.0021217797093360936 0.01605522744975571 0.024883989409409685 1.0593680222289763e-07 6.974953140687851 -1.4209648658794463 ANLQIDQINTDLNLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANLQIDQINTDLNLER 16 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 23081400.0 4142400.0 10239000.0 8700000.0 False True 5362418.458911496 9669190.649195628 7116689.269538382 1.0 1.8031398935543632 1.3271417223531974 22.35445237444108 -10.409584597639185 5.262090470195497 0.9995580863624369 1.565140807953794 0.6527170546599759 0.19432543965684945 0.0010082168784657922 0.00011312372368910207 0.18829646617632334 0.06271826596127741 3.8941744442044126e-11 10.409584597639185 0.5655827215913571 ANLSLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANLSLLR 7 0 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 19572000.0 2990200.0 8057900.0 8523900.0 False True 3920181.157137987 6855692.729448185 7641928.5950223785 1.0 1.748820387283666 1.9493814925128443 21.902488894191627 -10.933837876426534 0.25578868258884846 5.173542414334183e-13 2.0421206265051715 0.9992163502843727 0.011437086465225364 2.8380508018549047 0.13421506865756494 1.778066208854373 0.08889529919338247 1.1645606826499293e-11 10.933837876426534 2.042120626504654 ANLSLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANLSLLR 7 0 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 17349100.0 2990200.0 4975100.0 9383800.0 False True 4095757.747116584 4755283.631544366 7167539.705427421 1.0 1.1610265853472628 1.7499911244685733 21.96569895571452 -6.946933649629183 0.5915608119380453 0.9932233650483824 1.9475092642599496 0.9989380694634508 0.010505123233246542 0.08474110397569086 0.04124354268991642 0.010873611632841604 0.049363666453624076 1.129968535112567e-07 6.946933649629183 0.9542858992115673 ANLVLLSGANEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANLVLLSGANEGK 13 0 O43847-2;G3V1R5;O43847;F5H7V1;H0Y5G9 O43847-2 NRD1 Nardilysin 0 4386600.0 1015900.0 1399400.0 1971300.0 False True 1331854.7379895952 1190614.974818476 1767328.7860448407 1.0 0.8939525767019326 1.3269681262031503 20.345005309233205 -6.8419509880309395 1.273314879821107 0.9435923991832511 1.3417683902306392 0.9277564162353973 0.04953307931378207 0.16653121828530884 0.5236381049758235 0.030493247678905804 0.07029113470254361 1.4389609619232353e-07 6.8419509880309395 0.3981759910473881 ANLVLLSGANEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANLVLLSGANEGK 13 0 O43847-2;G3V1R5;O43847;F5H7V1;H0Y5G9 O43847-2 NRD1 Nardilysin 0 2846300.0 1015900.0 0.0 1830400.0 False True 1391505.683665221 0.0 1398097.218271312 1.0 0.0 1.0047369800091142 20.408215370756096 -12.034324352777231 14.411213422111324 0.8763749764666984 0.5521316410041143 0.0 0.4865823016658793 0.0 0.0 0.0 0.1395992049778448 9.240078210545526e-13 12.034324352777231 -0.3242433354625841 ANNFPINHK(ub)TR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANNFPINHKTR 11 1 Q8N123 Q8N123 CPXCR1 CPX chromosomal region candidate gene 1 protein 1 3103380.0 628380.0 1410900.0 1064100.0 True False 823812.2652405754 1200399.2196451256 953997.1395679591 1.0 1.4571271517723479 1.1580273562561807 19.6519560802133 -10.301484591905638 5.142408452299083 0.9999213130563752 1.307577254014317 0.5850599048790373 0.1221069801977498 0.00011018480836275911 1.4967006204328954e-05 0.11825971761413506 0.039409858396770595 4.994769005593397e-11 10.301484591905638 0.3076559409579417 ANNFPINHK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANNFPINHKTR 11 1 Q8N123 Q8N123 CPXCR1 CPX chromosomal region candidate gene 1 protein 1 5018200.0 1581700.0 1359000.0 2077500.0 True False 1531489.7992788088 1901655.7870913758 1533340.4263359357 1.0 1.2417032016712624 1.0012083835347767 20.546504327002875 -10.80389714842996 2.847755681896105 0.9664525121152001 1.1214557925028223 0.2537683149293434 0.09818159960453803 103613766.70570016 72425001.171501 23894995.854142893 0.03593078696013636 1.5707347487479216e-11 10.80389714842996 0.15500328038762223 ANNFPINHK(ub)TR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANNFPINHKTR 11 1 Q8N123 Q8N123 CPXCR1 CPX chromosomal region candidate gene 1 protein 1 2687080.0 628380.0 1015500.0 1043200.0 True False 860709.0673309877 970631.8521905718 796817.6453784051 1.0 1.1277118936372412 0.9257688522432947 19.71516614173619 -6.735795410742786 1.7020880893172456 1.076355553917546 0.9257555641583857 0.5859309113646645 0.05366706031034579 0.3254731695037332 1.8497413254533066 0.024960678751258316 0.06153628861200088 1.8374037113111347e-07 6.735795410742786 -0.15059998975916034 ANNFPINHK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANNFPINHKTR 11 1 Q8N123 Q8N123 CPXCR1 CPX chromosomal region candidate gene 1 protein 1 5439300.0 1581700.0 2738100.0 1119500.0 True False 1315253.6311907955 2723349.311829702 1353582.2740168374 1.0 2.0705887041452637 1.029141636196313 20.32690960243715 -6.639761474847472 2.0455289979738844 1.7002324288949575 1.0334833230596878 0.15366146528027846 0.45810081239431766 0.5339328773170874 4.269595991791427 0.18240335579337058 0.5072057398802675 2.2921261988990017e-07 6.639761474847472 -0.6667491058352697 ANNPGIVLTFVLPTEQFHLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANNPGIVLTFVLPTEQFHLGK 21 0 H7C3E9;Q9NY93;Q9NY93-2 H7C3E9 DDX56 Probable ATP-dependent RNA helicase DDX56 0 182751000.0 54336000.0 53298000.0 75117000.0 False True 82431684.49369444 43786555.48082535 60270092.02504927 1.0 0.5311859844884618 0.7311520126664353 26.296695640888924 -10.246654232576578 5.56504966641776 1.0000236821324682 0.6311689985774352 0.8193669165034865 0.08163578915455366 2.3988284856505813e-05 3.2473320893202044e-06 0.07904858108648731 0.026347837654166987 5.666902850045463e-11 10.246654232576578 -0.3688546835550329 ANNPGIVLTFVLPTEQFHLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANNPGIVLTFVLPTEQFHLGK 21 0 H7C3E9;Q9NY93;Q9NY93-2 H7C3E9 DDX56 Probable ATP-dependent RNA helicase DDX56 0 132933000.0 54336000.0 39936000.0 38661000.0 False True 70339023.12268625 37713526.49343456 31625094.695359003 1.0 0.5361679025262284 0.44960952386555175 26.067821962981373 -13.999999999999998 0.23606865391123522 4.01268149802186 0.40988269585836495 0.9995186552042905 0.005301743434534271 13.487922062848597 0.15380050430372605 19.1122359376541 0.043295331171905836 1.0000000000000041e-14 13.999999999999998 -3.602798802163495 ANPDPNCCLGVFGLSLYTTER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANPDPNCCLGVFGLSLYTTER 21 0 P62995-3;P62995 P62995-3 TRA2B Transformer-2 protein homolog beta 0 2368880.0 1714600.0 0.0 654280.0 False True 2247857.204210017 0.0 586581.3818969306 1.0 0.0 0.26095135438244077 21.100118960167098 -10.438816040100907 5.962520178142618 1.0003919322947374 0.13047567719137054 0.9367254281481194 0.10653294432086216 0.0005552769354624808 5.2261846473137663e-05 0.10319356141992679 0.03438335993142828 3.6406921711884605e-11 10.438816040100907 -0.8699162551033669 ANPDPNCCLGVFGLSLYTTER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANPDPNCCLGVFGLSLYTTER 21 0 P62995-3;P62995 P62995-3 TRA2B Transformer-2 protein homolog beta 0 142715000.0 32642000.0 58807000.0 51266000.0 False True 49520300.44985226 48312431.388811804 41133252.62931395 1.0 0.9756086079836364 0.8306341491398741 25.561516731917933 -6.936038290416063 0.6954760143323233 1.0017912987491688 0.7957145621018376 0.9975970682203993 0.003664556086116207 0.0896220868924797 0.06320176051914167 0.0034679144188421067 0.012710672837193808 1.1586751948037599e-07 6.936038290416063 -0.20607673664733128 ANPDPNCCLGVFGLSLYTTER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANPDPNCCLGVFGLSLYTTER 21 0 P62995-3;P62995 P62995-3 TRA2B Transformer-2 protein homolog beta 0 4690660.0 1714600.0 845560.0 2130500.0 False True 2348533.9553227522 808200.3633070012 1627319.7790248184 1.0 0.3441297331364036 0.69290877201781 21.16332902168999 -10.650323767455548 6.7717898373646594 1.0020636924158182 0.5185192525773303 0.7175897795946855 0.14238844637296336 0.004450740881091349 0.00022982329144798306 0.13831447825971388 0.04595567345790292 2.2370527891770122e-11 10.650323767455548 -0.4835444398384878 ANPDPNCCLGVFGLSLYTTER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANPDPNCCLGVFGLSLYTTER 21 0 P62995-3;P62995 P62995-3 TRA2B Transformer-2 protein homolog beta 0 85503000.0 32642000.0 22659000.0 30202000.0 False True 42255712.47001479 21398006.73113817 24705545.898689475 1.0 0.5063932301773986 0.5846675976939415 25.332643054010383 -10.722283165191135 6.872798281779749 1.0056080648911412 0.5455304139357475 0.9782362114749649 0.031955376725768786 0.002758097063972909 0.00011144935047274339 0.031077543219910107 0.010313553490057218 1.895469649364552e-11 10.722283165191135 -0.46007765095539366 ANPDPNTCLGVFGLSLYTTER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANPDPNTCLGVFGLSLYTTER 21 0 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 0 44176000.0 10781000.0 18426000.0 14969000.0 False True 16355565.196674757 15137736.337004919 12010370.588854218 1.0 0.9255403989391064 0.734329290637785 23.963278279477578 -6.954884069184737 0.502372797812523 1.0037518560827052 0.6478373832867793 0.9995309134854705 0.0024234864678003543 0.08158181402349944 0.02828956944439162 0.0028296008743705346 0.015774594592918967 1.1094709385384368e-07 6.954884069184737 -0.3559144727959259 ANPDPNTCLGVFGLSLYTTER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANPDPNTCLGVFGLSLYTTER 21 0 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 0 20994000.0 10781000.0 0.0 10213000.0 False True 13956217.02528122 0.0 8354338.7942293715 1.0 0.0 0.5986105532104986 23.734404601570027 -10.082993166481705 6.604254498245249 1.0000006157186971 0.29930527660524814 0.6462518870903434 0.24438173500181837 2.215648967214776e-06 3.0752040788247755e-07 0.23662180545400416 0.07887386581494236 8.260509471861414e-11 10.082993166481705 -0.700695339113449 ANPFGGASHAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANPFGGASHAK 11 0 P62266;D6RD47;D6RIX0;D6R9I7;D6RDJ2 P62266 RPS23 40S ribosomal protein S23 0 13424400.0 513500.0 6975900.0 5935000.0 False True 673203.4727410744 5935122.911845225 5320903.132540017 1.0 8.816239297874173 7.903855740486544 19.360683093311156 -10.45334486148112 6.642850736051472 0.9982800001931558 8.36004751918033 0.9886059493280804 0.37247902755083734 0.009483951237368142 0.0007804560097411696 0.3604843525147374 0.12021708920966051 3.5209117394571816e-11 10.45334486148112 7.3617675189871745 ANPFGGASHAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANPFGGASHAK 11 0 P62266;D6RD47;D6RIX0;D6R9I7;D6RDJ2 P62266 RPS23 40S ribosomal protein S23 0 9402500.0 3308600.0 1097800.0 4996100.0 False True 3203570.3040360785 1536157.2649513723 3687471.530212741 1.0 0.4795141417736379 1.1510506029997252 21.611249220875592 -6.699798009955157 1.8317514225898954 0.6767360450290097 1.149036546212576 0.41658788526005575 0.21971119993863086 0.39591967376434195 2.5825673821043256 0.09569933653921889 0.24616006085295003 1.996190525845792e-07 6.699798009955157 0.47230050118356626 ANPFGGASHAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANPFGGASHAK 11 0 P62266;D6RD47;D6RIX0;D6R9I7;D6RDJ2 P62266 RPS23 40S ribosomal protein S23 0 11942600.0 513500.0 5288700.0 6140400.0 False True 703354.8268157213 5055027.746607846 4690163.985507628 1.0 7.1870236101077625 6.668275821382042 19.423893154834047 -9.96303115512982 8.538774055757731 0.9999999919057386 6.927649715744902 0.9942888798199141 0.2117778979291846 3.557565384544608e-08 1.4313665452954683e-09 0.20505306947139484 0.06835102264787879 1.0888519791897067e-10 9.96303115512982 5.927649723839163 ANPFGGASHAK(ub)GIVLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANPFGGASHAKGIVLEK 17 1 P62266;D6RD47;D6RIX0;D6R9I7;D6RDJ2 P62266 RPS23 40S ribosomal protein S23 1 56360500.0 6536900.0 9419600.0 40404000.0 True False 6329389.687618147 13180895.402565064 29820980.305981774 1.0 2.082490738143388 4.7115096048389935 22.593634963591338 -6.95607954367668 0.4875640646011 0.9411752403403293 5.9638464495994095 0.9995960015619333 0.03132434774782669 0.08113260723306538 0.02654174998971064 0.037655601057081406 0.21683567599653447 1.1064211176591011e-07 6.95607954367668 5.02267120925908 ANPFGGASHAK(ub)GIVLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANPFGGASHAKGIVLEK 17 1 P62266;D6RD47;D6RIX0;D6R9I7;D6RDJ2 P62266 RPS23 40S ribosomal protein S23 1 163716100.0 11053000.0 16516000.0 136147100.0 True False 16768209.082538346 13568590.75990301 109237566.0096062 1.0 0.8091854468842905 6.514563688459805 23.999225275253725 -6.899160998683656 0.9665473062945223 0.757299667125561 7.103358474634483 0.9861445316386699 0.3114248731102156 0.11202581730759718 0.1809192358445549 0.24202882005159498 0.6271148501320027 1.261359845201283e-07 6.899160998683656 6.346058807508922 up ANPFGGASHAK(ub)GIVLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANPFGGASHAKGIVLEK 17 1 P62266;D6RD47;D6RIX0;D6R9I7;D6RDJ2 P62266 RPS23 40S ribosomal protein S23 1 40276900.0 6536900.0 14554000.0 19186000.0 True False 5435721.983771317 14475594.713257201 23197703.893958963 1.0 2.6630491324749466 4.26763987621463 22.374040239025614 -6.971562093093547 0.21766924856149175 0.23790661812736957 6.737969270240849 0.999992137152829 0.0037408571746730497 0.07579903223312626 0.0071884213050663545 0.04524951182375334 0.16344657638521543 1.0676721315963758e-07 6.971562093093547 6.5000626521134794 ANPFGGASHAK(ub)GIVLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANPFGGASHAKGIVLEK 17 1 P62266;D6RD47;D6RIX0;D6R9I7;D6RDJ2 P62266 RPS23 40S ribosomal protein S23 1 123544000.0 11053000.0 26485000.0 86006000.0 True False 14308326.38720278 25011086.467813883 70353790.49608253 1.0 1.7480092214127532 4.916982503209197 23.770351597346174 -6.94355658636359 0.6256005044349912 0.9654113537896876 5.869087655374367 0.9985936276727752 0.06367264676419518 0.08618089573329782 0.04749747148731442 0.06379949150414228 0.26876872407911406 1.1387893937389637e-07 6.94355658636359 4.903676301584679 ANPLAYGISHK(ub)AYQIDPTLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANPLAYGISHKAYQIDPTLR 20 1 Q8N3C0 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 1 48892000.0 9152000.0 22454000.0 17286000.0 True False 13884253.100822484 18446908.266097244 13869414.523277048 1.0 1.328620857898685 0.9989312656980766 23.726946234114273 -10.538947213981599 9.759703196564061 0.9999948178250071 1.1637760617983808 0.24756879680695276 0.1345952123996265 1.5177229103410534e-05 7.169526740286129e-07 0.13032537512639802 0.04344041800858361 2.8910312493785637e-11 10.538947213981599 0.16378124397337368 ANPLAYGISHK(ub)AYQIDPTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANPLAYGISHKAYQIDPTLR 20 1 Q8N3C0 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 1 12300900.0 2906800.0 4194900.0 5199200.0 True False 3981522.5133163366 4009555.4473207565 3971256.0408851625 1.0 1.0070407573762707 0.997421470707038 21.924888784612772 -6.71056068721302 1.7939421254520804 1.0043261389655582 0.9974443918582736 0.4674983695252726 0.002966674366460977 0.373912821078586 2.3462050301724107 0.0013160609346590526 0.003340222576680911 1.9473289161092588e-07 6.71056068721302 -0.006881747107284619 ANPQVGVAFPHIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANPQVGVAFPHIK 13 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 20620000.0 4150300.0 5058700.0 11411000.0 False True 5441083.491562377 4303961.678658156 10230299.182041127 1.0 0.7910118794046105 1.8801952217615308 22.375462535553005 -6.85699974827186 1.2008482784497954 0.8873992220747801 1.929982418281883 0.9498805288323642 0.10566009924757247 0.14992748743911186 0.41255002882987474 0.0687057314529698 0.15987155138988426 1.3899534368655248e-07 6.85699974827186 1.042583196207103 ANPQVGVAFPHIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANPQVGVAFPHIK 13 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 12239500.0 4150300.0 3753100.0 4336100.0 False True 5684778.067640288 3587275.6321579865 3312002.484782686 1.0 0.6310317816236298 0.5826089330796823 22.438672597075897 -13.999999999999998 0.2862455975436381 4.113102645691923 0.5689071864613813 0.9996190678505941 0.0036380134546157533 15.746348503076135 0.16958867600305064 28.802820495381564 0.01860371447905598 1.0000000000000041e-14 13.999999999999998 -3.5441954592305414 ANPQVGVAFPHIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANPQVGVAFPHIK 13 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 4502200.0 1377300.0 1723800.0 1401100.0 False True 1145285.974735463 1714513.5472524911 1694063.5320455474 1.0 1.4970178497545188 1.4791620341258789 20.12727644958443 -10.077757690963782 4.846157588270942 0.9999834359713409 1.4880899419451272 0.9989972665398079 0.007289606222224294 5063021.458900011 0.14482090437456874 935.8165344049451 0.0024954260994605702 8.360693623016537e-11 10.077757690963782 0.48810650597378635 ANQEQYAEGK(ub)MR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANQEQYAEGKMR 12 1 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;H0YNE0 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 1 19867450.0 10844370.0 8203600.0 819480.0 True False 14217074.08702848 6979654.857382337 734688.0706072268 1.0 0.4909346898424414 0.051676460719688386 23.76112124910757 -8.004575527164567 0.4918107244314983 1.0307030571028064 3.524254698570459e-21 0.9943376274596519 0.02915895617590711 0.10309938803323312 0.12273572193048672 0.0434027386559849 0.0780082970883674 9.895197637755415e-09 8.004575527164567 -1.0307030571028064 ANQEQYAEGK(ub)MR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANQEQYAEGKMR 12 1 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;H0YNE0 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 1 31736030.0 14555430.0 14550400.0 2630200.0 True False 14093375.84188957 20360450.5993336 1941271.7156913476 1.0 1.4446822981060705 0.13774355679363418 23.748513891686198 -6.814883302204617 1.3937523887279637 1.2409975954316967 0.11220184275417293 0.8722184525054468 0.19394554679723017 0.2002254711797988 0.765572801949116 0.10938332214533106 0.25253247773315707 1.5314989302740265e-07 6.814883302204617 -1.1287957526775239 down ANQHK(ub)EQQLGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANQHKEQQLGLK 12 1 Q9UBW8;F5GYF7;F5H248 Q9UBW8 COPS7A COP9 signalosome complex subunit 7a 1 4466300.0 1273300.0 2039200.0 1153800.0 True False 1669308.6306547397 1734959.308739343 1034415.8440311148 1.0 1.039328064852126 0.6196672233254998 20.670819281814687 -6.88395512649225 1.0575185954504362 1.025923516144361 0.5875779884558192 0.9767372636559318 0.028863524014560903 0.12418326352867758 0.2516166554871412 0.020944754600557537 0.0511980517983342 1.3063058553029366e-07 6.88395512649225 -0.43834552768854174 ANQHK(ub)EQQLGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANQHKEQQLGLK 12 1 Q9UBW8;F5GYF7;F5H248 Q9UBW8 COPS7A COP9 signalosome complex subunit 7a 1 4055800.0 1273300.0 1289100.0 1493400.0 True False 1744073.4196386694 1232143.2995163612 1140689.6775384492 1.0 0.7064744440469898 0.6540376481253714 20.73402934333758 -13.999999999999998 0.2422587278270052 2.964340498063425 0.6313446304455875 0.9995287647894883 0.003304842672490789 13.70419556722549 0.1557705317568376 13.040270662709068 0.02528684473766713 1.0000000000000041e-14 13.999999999999998 -2.3329958676178375 ANQHK(ub)EQQLGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANQHKEQQLGLK 12 1 Q9UBW8;F5GYF7;F5H248 Q9UBW8 COPS7A COP9 signalosome complex subunit 7a 1 4426940.0 1075900.0 868740.0 2482300.0 True False 1392773.7591596362 820393.8553161653 2030546.870548864 1.0 0.5890359794049895 1.457915800893638 20.409529496289345 -6.77807809307608 1.5432616573743378 0.7667215807052368 1.464400021771557 0.7605622051451595 0.17365675959881746 0.25357259606584076 1.1927132376450529 0.08863814217153598 0.20949579063071147 1.6669474418574892e-07 6.77807809307608 0.6976784410663202 ANQSLK(ub)HLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANQSLKHLR 9 1 A0A0G2JPH3;A0A0G2JNK3;Q8WX94-2;Q8WX94-3;A0A0G2JNK1;A0A0G2JMB6;Q8WX94;A0A0G2JM25;K7ERG0 A0A0G2JPH3 NLRP7 NACHT, LRR and PYD domains-containing protein 7 1 4470020.0 813410.0 882710.0 2773900.0 True False 676386.4551728548 877954.6660257832 3353909.6649355115 1.0 1.2980074620231954 4.958570118141113 19.367488244103974 -6.9230596508981 0.8017079555986415 0.9277882405186652 5.592511311873065 0.9949894939413738 0.1274102593763751 0.09640475415955245 0.09652960730859604 0.11159477814816994 0.34471632480512493 1.1938241199452524e-07 6.9230596508981 4.6647230713544 up ANQTK(ub)EGLPVALDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANQTKEGLPVALDK 14 1 Q9Y224 Q9Y224 C14orf166 UPF0568 protein C14orf166 1 9163500.0 3279300.0 3613400.0 2270800.0 True False 4299194.056786369 3074294.804922882 2035839.3990517054 1.0 0.7150863078790414 0.4735397779586362 22.03563480140504 -7.051333258438324 0.1764866817702793 1.2009451087609917 4.2986562296313737e-10 0.9999970325306063 0.00037061327985673885 0.07262285250655509 0.00569352907220868 0.01016795607178376 0.027286205672461594 8.885190458524884e-08 7.051333258438324 -1.200945108331126 down ANQTK(ub)EGLPVALDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANQTKEGLPVALDK 14 1 Q9Y224 Q9Y224 C14orf166 UPF0568 protein C14orf166 1 12075300.0 3279300.0 4950200.0 3845800.0 True False 4491745.829750321 4731483.795877659 2937501.2467372217 1.0 1.0533730035523101 0.6539776198557758 22.09884486292793 -6.873217508597216 1.1169908511226732 1.0308579595315772 0.6291168861219609 0.9677874983808312 0.031775330310716846 0.13380443079811719 0.3100740217735232 0.022032120727704232 0.05247145573812141 1.3390059023888259e-07 6.873217508597216 -0.4017410734096163 ANQTK(ub)EGLPVALDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANQTKEGLPVALDK 14 1 Q9Y224 Q9Y224 C14orf166 UPF0568 protein C14orf166 1 12606600.0 4645200.0 5032500.0 2928900.0 True False 3862689.6172519946 5005388.923626963 3541319.448296482 1.0 1.2958299577763928 0.9168014516309643 21.881174325164373 -6.698454679297774 1.8359969326817864 1.1839822025126931 0.9179507380897874 0.4102308601269342 0.12491064134134881 0.3988493072832134 2.612671079944625 0.05429345694257295 0.13991530865471472 2.0023745680307774e-07 6.698454679297774 -0.2660314644229057 ANSFTVSSVAAPSWLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANSFTVSSVAAPSWLHR 17 0 A0A024R4E5;Q00341;Q00341-2;H0Y394;H7C0A4 A0A024R4E5 HDLBP Vigilin 0 77175900.0 25683300.0 25667700.0 25824900.0 False True 33671055.01743097 21838179.211910985 23152787.07793306 1.0 0.6485742487310157 0.6876169180308496 25.005005590146027 -10.118272461266598 7.757744283241765 1.000000047950902 0.6680955836231771 0.9897285826898969 0.015939102996803144 1.3227762048317504e-08 1.482191434042329e-09 0.015432972414706364 0.00514432337167528 7.61601058076991e-11 10.118272461266598 -0.3319044643277248 ANSFTVSSVAAPSWLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANSFTVSSVAAPSWLHR 17 0 A0A024R4E5;Q00341;Q00341-2;H0Y394;H7C0A4 A0A024R4E5 HDLBP Vigilin 0 69252400.0 24428700.0 8231000.0 36592700.0 False True 23653224.29009432 11517681.224097949 27007974.11253093 1.0 0.4869391624093047 1.1418305505115234 24.495533522206184 -6.697777030396167 1.8392124217263581 0.680707083977783 1.1397753365876604 0.4068287155459108 0.21666010718511353 0.40017369077575166 2.6302455786070325 0.0940435086003573 0.24248365840180602 2.0055014005257881e-07 6.697777030396167 0.4590682526098774 ANSFTVSSVAAPSWLHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANSFTVSSVAAPSWLHR 17 0 A0A024R4E5;Q00341;Q00341-2;H0Y394;H7C0A4 A0A024R4E5 HDLBP Vigilin 0 37939800.0 7688800.0 15238000.0 15013000.0 False True 11664471.726573855 12518659.844962582 12045673.969568351 1.0 1.073229901740233 1.0326806264295747 23.475617634653226 -10.207472236091066 5.022026685083638 0.9999944561394074 1.0529552640849547 0.6945633747956845 0.016554172325302145 1.0276598315880298e-06 1.622107064308423e-07 0.01603018642415491 0.005342836143819844 6.201942906401983e-11 10.207472236091066 0.05296080794554725 ANSFTVSSVAAPSWLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANSFTVSSVAAPSWLHR 17 0 A0A024R4E5;Q00341;Q00341-2;H0Y394;H7C0A4 A0A024R4E5 HDLBP Vigilin 0 76872000.0 25683300.0 22137700.0 29051000.0 False True 35179110.075085066 21159583.21441576 22189752.124125835 1.0 0.6014814806074822 0.6307650215359286 25.06821565166892 -10.032560060126144 6.2162171756266655 1.0000003718561807 0.6161232510716952 0.9956545614179078 0.011954955522803169 6.160985713320172e-08 9.586861146463399e-09 0.011575347208601787 0.003858445303700246 9.277691767609849e-11 10.032560060126144 -0.38387712078448555 ANSFTVSSVAAPSWLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANSFTVSSVAAPSWLHR 17 0 A0A024R4E5;Q00341;Q00341-2;H0Y394;H7C0A4 A0A024R4E5 HDLBP Vigilin 0 52045400.0 24428700.0 10427000.0 17189700.0 False True 20313546.42490393 10370827.681402557 20783986.793807272 1.0 0.5105375233094782 1.023158948174928 24.27593879764046 -10.982465414715813 12.656001940638888 1.1398688360183298 0.7668482357422046 0.21618915724649523 0.20927682035646944 0.07560464455315515 0.00010474834933663893 0.01854876648446781 0.06754380333232064 1.0412010209480445e-11 10.982465414715813 -0.37302060027612516 ANSFTVSSVAAPSWLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANSFTVSSVAAPSWLHR 17 0 A0A024R4E5;Q00341;Q00341-2;H0Y394;H7C0A4 A0A024R4E5 HDLBP Vigilin 0 50058800.0 7688800.0 29516000.0 12854000.0 False True 9953303.168906607 27873408.653350778 10514703.893177748 1.0 2.8004179296402096 1.0564034587055398 23.246743956745675 -6.638766389887585 2.0486008682572865 2.1784993982027343 1.0636133411366477 0.14984710487060982 0.7705908847407518 0.5366184031888859 4.302530304961702 0.3064570384989953 0.8534558700476522 2.2973840951642822e-07 6.638766389887585 -1.1148860570660866 ANSGLSMESIHVPDPVISIAMKPSNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANSGLSMESIHVPDPVISIAMKPSNK 26 1 Q96RP9;Q96RP9-2;C9IZ01 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 37445000.0 7901000.0 18554000.0 10990000.0 False True 11986394.64047185 15242893.73693635 8817821.682911882 1.0 1.2716829533935907 0.7356525416857762 23.51489444335591 -6.768939965289732 1.5787163259051447 1.1560442251587897 0.7327729565117367 0.7263985897025914 0.11446864061591126 0.26815625286277406 1.3188619045887788 0.057159916031186336 0.13618571912061328 1.7023938225895507e-07 6.768939965289732 -0.423271268647053 ANSLK(ub)NSGVPDDIFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANSLKNSGVPDDIFK 15 1 Q13045;Q13045-2;Q13045-3;J3KS54;K7EP37;K7EP27 Q13045 FLII Protein flightless-1 homolog 1 4824650.0 430650.0 1412900.0 2981100.0 True False 416979.251475892 1977078.3381761617 2200260.4789169943 1.0 4.741430973311794 5.276666575445192 18.669616072644967 -9.765259717504001 0.5066224952113428 1.1186218534120897e-22 5.262630100156676 0.9989232608468925 0.06242721218195812 1.0530783791638905 0.22643044650843772 1.9087435616495936 0.10684282946320507 1.7168813478704945e-10 9.765259717504001 5.262630100156676 ANSLK(ub)NSGVPDDIFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANSLKNSGVPDDIFK 15 1 Q13045;Q13045-2;Q13045-3;J3KS54;K7EP37;K7EP27 Q13045 FLII Protein flightless-1 homolog 1 4496520.0 430650.0 889970.0 3175900.0 True False 358104.55602978787 885175.5549647857 3839966.0062975176 1.0 2.471835501839175 10.72303030397106 18.450021348079243 -6.937288887863616 0.6843205992543064 0.9016140591552928 12.78119618998672 0.9977868063177775 0.2013021404543068 0.0890254909620589 0.06040696052720675 0.19213945368804553 0.7190562838593004 1.1553434648943594e-07 6.937288887863616 11.879582130831427 ANSMGLFLQK(ub)TNIIR ddPTM_RPMI8226_Bortezomib_2h_R1 2 ANSMGLFLQKTNIIR 15 1 P37268;P37268-5;E9PNM1;A0A1W2PQ47;P37268-2;P37268-3;P37268-4 P37268 FDFT1 Squalene synthase 1 78213560.0 3520190.0 5569270.0 69124100.0 True False 3408443.495304586 7793108.55435937 51018424.531450234 1.0 2.286412717445668 14.968247119757846 21.70068163577073 -6.926431194011456 0.7755388851323655 0.77949703485259 17.34985420698563 0.9957888681775243 0.40904803708850535 0.09453395263920059 0.08707592058824142 0.36503322419709117 1.1708137414732924 1.1845920289930411e-07 6.926431194011456 16.57035717213304 ANSMGLFLQK(ub)TNIIR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ANSMGLFLQKTNIIR 15 1 P37268;P37268-5;E9PNM1;A0A1W2PQ47;P37268-2;P37268-3;P37268-4 P37268 FDFT1 Squalene synthase 1 97561390.0 3520190.0 7981200.0 86060000.0 True False 2927193.955858583 7938203.691455828 104054748.10351849 1.0 2.7118816898238136 35.54760964686329 21.481086911205008 -6.917699592040191 0.84160208910156 0.21369313015970356 40.57244318485185 0.9935178268987874 1.2799606701293271 0.09954468664004786 0.11276449572399135 1.089585318411033 3.195426702423209 1.2086495869386297e-07 6.917699592040191 40.358750054692145 up ANSPEKPPEAGAAHK(ub)PR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANSPEKPPEAGAAHKPR 17 2 Q9UFC0;F8WDB4 Q9UFC0 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 1 5311570.0 2657000.0 741460.0 1913110.0 True False 3439538.8773000846 700197.0992042779 1564943.6101662745 1.0 0.20357295677783052 0.4549864577761945 21.71378373191884 -10.233346710200708 5.447076786326562 1.0000447220917268 0.329279707289192 0.9046667909572743 0.10263913198230401 5.574792884031054e-05 7.84642270619314e-06 0.09938650666957077 0.03312663740302694 5.843234151314646e-11 10.233346710200708 -0.6707650148025348 ANSSVVSVNCK(ub)GK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANSSVVSVNCKGK 13 1 O60502-2;O60502-4;O60502;O60502-3 O60502-2 MGEA5 Protein O-GlcNAcase 1 22430700.0 1540500.0 3250600.0 17639600.0 True False 2337051.1256356025 2670505.0329462807 14153125.328288684 1.0 1.1426814773767473 6.055975914707253 21.156257864375235 -6.91310909925046 0.8743005917781163 0.8624228445716905 6.73503389518055 0.9920428076541276 0.2096720046124607 0.10239761341813838 0.12788272441854948 0.17434514962730055 0.49229447182665187 1.2214927700448085e-07 6.91310909925046 5.872611050608859 up ANSSVVSVNCK(ub)GK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANSSVVSVNCKGK 13 1 O60502-2;O60502-4;O60502;O60502-3 O60502-2 MGEA5 Protein O-GlcNAcase 1 19495370.0 1540500.0 2860770.0 15094100.0 True False 1994207.617794796 2701565.6346810614 12347128.678544747 1.0 1.3547063056897082 6.191496095175014 20.927384186467684 -6.9216319115036 0.8125230033634063 0.8994272531832157 7.001544069741501 0.9946225366928675 0.1736571463438172 0.09722110209174979 0.10070551362430766 0.15093117317949709 0.45941741581027373 1.1977552647901519e-07 6.9216319115036 6.102116816558285 up ANTFVAELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANTFVAELK 9 0 P40926;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 160566000.0 66712000.0 42537000.0 51317000.0 False True 87460078.03992692 36190645.40792738 46007209.10742311 1.0 0.4137961709959346 0.5260366802602221 26.382121299936458 -10.00925582015886 6.005584169838512 1.0000005947668917 0.4699164256284903 0.9674681682119028 0.04582199602812434 3.649313892226356e-07 6.021612332520295e-08 0.044367006457529216 0.014788985625548489 9.78913188997994e-11 10.00925582015886 -0.5300841691384015 ANTFVAELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANTFVAELK 9 0 P40926;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 111015000.0 35156000.0 19737000.0 56122000.0 False True 34039992.02342145 27618087.02709531 41421964.576089285 1.0 0.811342347204209 1.2168617591798676 25.020727363169264 -6.780205434899229 1.535149155666737 0.8932067380094229 1.220090722278326 0.7681017463559496 0.07978745520463362 0.2502489284291808 1.1649114908597795 0.040935873493489455 0.09657170301747238 1.6588020564688079e-07 6.780205434899229 0.3268839842689031 ANTFVAELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANTFVAELK 9 0 P40926;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 224324000.0 26272000.0 144180000.0 53872000.0 False True 39856544.740472905 118449952.5165183 43224175.58706364 1.0 2.9719072059007807 1.0844937981583493 25.248313309113687 -6.635927899900867 2.058949011869768 2.293485653825381 1.0922558112544243 0.13917424980017024 0.8445867384782443 0.543787863592691 4.400591940636958 0.33461557205719195 0.9354002691292894 2.3124486632059431e-07 6.635927899900867 -1.2012298425709567 ANTFVAELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANTFVAELK 9 0 P40926;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 164115000.0 66712000.0 35116000.0 62287000.0 False True 91377229.2240123 33564459.00691685 47576093.44103209 1.0 0.3673175395221626 0.5206558991233884 26.44533136145935 -10.296624376110884 8.553935186605706 1.0000005351255286 0.4439867193237909 0.9460364593531041 0.0626001231697335 6.388475081171409e-07 5.2582975195741516e-08 0.060612366424378006 0.020204102875575898 5.050979709449184e-11 10.296624376110884 -0.5560138158017376 ANTFVAELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANTFVAELK 9 0 P40926;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 71170000.0 35156000.0 20392000.0 15622000.0 False True 29233771.674871042 20282144.248504907 18888487.972033072 1.0 0.6937915666194782 0.6461187486207728 24.80113263860354 -13.999999999999998 0.2618164765964045 3.2629808595238594 0.6289954328146868 0.9995660617059475 0.0032662663654999067 14.49825165193035 0.16192769981591598 17.377622616491326 0.020644490078892543 1.0000000000000041e-14 13.999999999999998 -2.6339854267091725 ANTFVAELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANTFVAELK 9 0 P40926;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 155733000.0 26272000.0 76360000.0 53101000.0 False True 34009621.898542576 72110498.87416528 43437162.862271026 1.0 2.1202969879901974 1.2772021691935496 25.019439631206136 -10.13740773504569 4.4242466953582 0.9999240369505588 1.698749578417332 0.4780411464818055 0.34419201902855373 51993432.84018245 59567112.33333372 43873.01535515345 0.11782607887098226 7.28772984364358e-11 10.13740773504569 0.6988255414667733 ANTTAFLTPLEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANTTAFLTPLEIK 13 0 Q9Y5K6 Q9Y5K6 CD2AP CD2-associated protein 0 2294400.0 624120.0 967620.0 702660.0 False True 854874.030208818 924867.3489085584 536706.1797369535 1.0 1.0818755936271023 0.6278190245244127 19.705352322058484 -6.86023488109749 1.1844245900175567 1.0444555141047795 0.6057196739618143 0.953933495047403 0.04240976459034223 0.14656655515517894 0.3905502254958454 0.027922757656335204 0.06520273833836795 1.379637908100289e-07 6.86023488109749 -0.4387358401429653 ANVDISAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANVDISAPK 9 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5532110.0 1356000.0 447110.0 3729000.0 False True 1312954.5222368732 625643.354647848 2752263.0323979314 1.0 0.4765156325307772 2.096236378171665 20.324385514740335 -6.819712213658385 1.3732387224157043 0.7177704948224592 2.1313463529236496 0.8837021737882699 0.23015348785776477 0.19385036559087956 0.7184025867322783 0.1317108648989732 0.30357807323628316 1.5145645460243213e-07 6.819712213658385 1.4135758581011904 up ANVNEILDFFHGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANVNEILDFFHGYR 14 0 B9ZVT1;Q8IXT5 B9ZVT1 RBM12B RNA-binding protein 12B 0 3169700.0 1371400.0 816690.0 981610.0 False True 1327865.6576664078 1142798.5759820875 724496.8933312246 1.0 0.860628158717835 0.5456100842343163 20.340677763582494 -6.957583703806043 0.468245854474458 1.0084639100315889 0.3848981984809467 0.9996698195747773 0.003453687604417492 0.08057582792229571 0.024408072545591637 0.00434141992718036 0.026003586763794974 1.1025957044361951e-07 6.957583703806043 -0.6235657115506421 ANWYFLLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANWYFLLAR 9 0 B7Z9I1;Q5T4U5;P11310;P11310-2 B7Z9I1 ACADM Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 0 4779680.0 972480.0 2744400.0 1062800.0 False True 1274930.6975097165 2334946.2175874123 952831.6510974767 1.0 1.8314299139146872 0.7473595646874092 20.28198739674053 -6.701768217201421 1.824338800793614 1.5153766636083799 0.7504484060088584 0.4260933071065871 0.35084321274767577 0.39184610192876934 2.5366060871403273 0.15334453262816414 0.3935360908268479 1.9871551783590136e-07 6.701768217201421 -0.7649282575995214 ANWYFLLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANWYFLLAR 9 0 B7Z9I1;Q5T4U5;P11310;P11310-2 B7Z9I1 ACADM Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 0 4450900.0 1913900.0 1149700.0 1387300.0 False True 1853144.2921158953 1608781.2056062948 1023924.5118921032 1.0 0.868135963535473 0.5525336134095634 20.82154378820443 -6.956389227760912 0.4836510380738878 1.0073211016709887 0.40010885097832877 0.999611927702152 0.0036984029379036184 0.08101720175357373 0.026096509167416525 0.004483379565868688 0.026031758358005662 1.105632438802445e-07 6.956389227760912 -0.6072122506926598 ANWYFLLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ANWYFLLAR 9 0 B7Z9I1;Q5T4U5;P11310;P11310-2 B7Z9I1 ACADM Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 0 24821800.0 7838700.0 5957100.0 11026000.0 False True 11891880.985731766 4894008.9619652545 8846706.267132532 1.0 0.41154204013959045 0.7439282547266555 23.503473594110787 -10.213187064756903 5.705407589831684 1.0000136929316927 0.5777351474331417 0.6827313062944789 0.13569610387896472 2.3635665964468362e-05 3.259468335909772e-06 0.1313914435918891 0.04379572920569925 6.120866892936958e-11 10.213187064756903 -0.42227854549855104 ANWYFLLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANWYFLLAR 9 0 B7Z9I1;Q5T4U5;P11310;P11310-2 B7Z9I1 ACADM Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 0 6049980.0 972480.0 1779000.0 3298500.0 False True 1332032.1362838405 1700397.8976337032 2519462.234739906 1.0 1.2765441998851057 1.8914425306350402 20.34519745826342 -6.957921622485187 0.46380244497790507 0.9827414205135806 2.210191527490946 0.9996851624289327 0.006610676667393419 0.08045215897264363 0.023939543000089766 0.008406308102854797 0.050777045838076754 1.1017381232684537e-07 6.957921622485187 1.2274501069773653 ANWYFLLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANWYFLLAR 9 0 B7Z9I1;Q5T4U5;P11310;P11310-2 B7Z9I1 ACADM Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 0 4505700.0 1913900.0 1337100.0 1254700.0 False True 1591492.6501460853 1329896.7769064286 1517051.9689226681 1.0 0.8356286011024654 0.9532258718150007 20.601949063638706 -10.4697604233883 4.672348892067655 1.0003516313530239 0.8944272364586966 0.5179800533112078 0.04800888473173348 0.0001764348071260619 2.00225775756374e-05 0.04663858098194247 0.015494800919648626 3.390311295716947e-11 10.4697604233883 -0.10592439489432726 ANWYFLLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANWYFLLAR 9 0 B7Z9I1;Q5T4U5;P11310;P11310-2 B7Z9I1 ACADM Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 0 26180700.0 7838700.0 10588000.0 7754000.0 False True 10147351.67387735 9998768.492399972 6342851.56275869 1.0 0.9853574423896355 0.625074577743008 23.274599916203236 -6.915454709832631 0.8577506161824772 1.0093244016160001 0.572641983231422 0.9928225516805161 0.014689850935762996 0.10092070118757193 0.12001534953598095 0.012361079347107621 0.03556118051999422 1.2149133104488906e-07 6.915454709832631 -0.4366824183845781 ANYESPGK(ub)IFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANYESPGKIFLR 12 1 Q6P0N0;G5E9K5;Q6P0N0-2;C9J2Q8 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 4258810.0 903810.0 1626100.0 1728900.0 True False 1184903.6625084903 1383492.2184881554 1550010.0127798524 1.0 1.1675989046731823 1.308131675024463 20.17633833623577 -6.973156990050379 0.1663003162602209 0.8694732349202646 1.6100077174131067 0.9999976977929577 0.0001910259693051108 0.0752909644094874 0.00516699491687933 0.006128779473101068 0.016488337052119283 1.0637584181844979e-07 6.973156990050379 0.740534482492842 ANYESPGK(ub)IFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANYESPGKIFLR 12 1 Q6P0N0;G5E9K5;Q6P0N0-2;C9J2Q8 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 5768000.0 1885100.0 2445500.0 1437400.0 True False 1825258.5323515718 3422000.90311403 1060901.8189243188 1.0 1.8748034004285932 0.5812337266861073 20.799669393275906 -6.7245573437327595 1.7429887179957426 1.529613666368683 0.5827228565795151 0.5339078666341321 0.3679296791711464 0.3465324395989318 2.059796204615799 0.1674575924834732 0.41813328448010734 1.8855699846091627e-07 6.7245573437327595 -0.946890809789168 ANYESPGK(ub)IFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANYESPGKIFLR 12 1 Q6P0N0;G5E9K5;Q6P0N0-2;C9J2Q8 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 3389010.0 903810.0 1220200.0 1265000.0 True False 1237972.9815468676 1166287.529338193 966233.0534927933 1.0 0.9420944937593851 0.7804960753549478 20.23954839775866 -6.953063962543071 0.5241274844310934 1.0026609785180969 0.712666954440323 0.9994203152575228 0.0022363581750319715 0.08227822747783103 0.031047262348443412 0.0025171807172188723 0.01335389296234639 1.1141304332708583e-07 6.953063962543071 -0.28999402407777386 ANYESPGK(ub)IFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANYESPGKIFLR 12 1 Q6P0N0;G5E9K5;Q6P0N0-2;C9J2Q8 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 5879190.0 1885100.0 3021100.0 972990.0 True False 1567544.1740897563 3004824.7346586026 1176437.7104025376 1.0 1.9168995581278903 0.7504973255925455 20.580074668710182 -6.697074606337291 1.841015691923871 1.5709920960651809 0.7541258786309905 0.40371955612578736 0.38724831251173764 0.40170316413990836 2.6448040774205412 0.16792895896174154 0.43348134626688944 2.008747705340943e-07 6.697074606337291 -0.8168662174341904 ANYWWLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ANYWWLR 7 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 36263800.0 8327600.0 9230200.0 18706000.0 False True 10917564.244593104 7853090.139037808 16770482.560622344 1.0 0.7193078935099495 1.5361011105501745 23.38014768491827 -6.813917437642772 1.397866775508838 0.84771750794622 1.55172757332662 0.8698477657245941 0.12224382760956783 0.20150182509350653 0.7752285386411504 0.06874601833342064 0.15877075938392757 1.5349087517372072e-07 6.813917437642772 0.7040100653804 ANYWWLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ANYWWLR 7 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 24170900.0 9119400.0 2743500.0 12308000.0 False True 8829909.638707187 3838993.857163494 9084165.567914657 1.0 0.4347715904514706 1.0287948506395697 23.073967243386356 -10.073296152165332 13.367187012046971 1.0000000051879503 0.7317832205455201 0.21373384675854745 0.24250898046756195 0.0 0.0 0.23480831066415178 0.07826943688805058 8.447026328486628e-11 10.073296152165332 -0.26821678464243015 ANYWWLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ANYWWLR 7 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 28711900.0 8327600.0 9631300.0 10753000.0 False True 11406538.764928117 9205757.319550011 8213362.864986569 1.0 0.8070596619418954 0.7200574191919058 23.443357746441162 -13.999999995322712 0.10749761796867835 1.9353597601770962 0.5545476943243912 0.9997557814634143 0.0018281271434931227 12.027966598560207 0.09907336100747631 2.4536635679103296 0.14711392314309094 1.0000000107698535e-14 13.999999995322712 -1.380812065852705 ANYWWLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ANYWWLR 7 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 20416100.0 9119400.0 6939000.0 4357700.0 False True 7583185.157919537 6901618.229716342 5268874.922271701 1.0 0.9101212862392793 0.6948102693719834 22.854372518820632 -6.956369491644237 0.48389474877767724 1.004983327308384 0.5909120267710926 0.9996109491403794 0.002525755458619007 0.08102443878436415 0.02612405698384965 0.0030602130656405347 0.01775937471300227 1.1056826844020188e-07 6.956369491644237 -0.41407130053729135 ANYWWLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ANYWWLR 7 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 23879800.0 5835000.0 8366200.0 9678600.0 False True 7553522.525045529 7900613.6155191455 7917194.110822325 1.0 1.0459508910343158 1.0481459589974023 22.848718160023044 APAELK(ub)SPFQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APAELKSPFQR 11 1 Q9UP83-3;Q9UP83;Q9UP83-2 Q9UP83-3 COG5 Conserved oligomeric Golgi complex subunit 5 1 10654100.0 1120800.0 2222600.0 7310700.0 True False 1450897.6942709559 2098910.3561775773 5980227.614116578 1.0 1.446628776422609 4.121743137183432 20.46851436497179 -6.935872775731091 0.6969114525397622 0.9667825312501088 4.763205528246249 0.9975716293092061 0.06792770102167194 0.08970125538348267 0.06357053989394605 0.06421202979124337 0.23473170964880563 1.1591168635719743e-07 6.935872775731091 3.7964229969961396 up APAPRPSLLGLDLLASLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 APAPRPSLLGLDLLASLK 18 1 Q92620;Q92620-2;H3BV01;H3BQT9;J3KRT1 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 0 12530000.0 2682800.0 4806400.0 5040800.0 False True 4070003.7389517636 3948660.3674253942 4044483.670538874 1.0 0.970185931190908 0.9937297186809311 21.956598689163286 -10.021410388452615 4.644289758696788 1.0000005145589546 0.9819578249352142 0.4391486066907202 0.009611710996860852 5.121094513886001e-08 1.0780009034662629e-08 0.009306764590141544 0.0031021663845241716 9.518962404199977e-11 10.021410388452615 -0.018042689623740338 APAPRPSLLGLDLLASLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APAPRPSLLGLDLLASLK 18 1 Q92620;Q92620-2;H3BV01;H3BQT9;J3KRT1 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 0 2682800.0 2682800.0 0.0 0.0 False True 3472937.4858941096 0.0 0.0 1.0 0.0 0.0 21.727725011255735 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 APCCGADVK(ub)AHHEVCPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 APCCGADVKAHHEVCPK 17 1 Q12933-3;Q12933;Q12933-2;B1AMX8 Q12933-3 TRAF2 TNF receptor-associated factor 2 1 2851640.0 734860.0 984080.0 1132700.0 True False 963408.576394363 837259.0999137966 1015499.0696256225 1.0 0.8690592137422201 1.0540689532017793 19.877788241486616 -6.716531569363248 1.771451575380269 0.9200473625562782 1.053733388011018 0.4963199148508022 0.05512469893115077 0.36206827801040586 2.218465921834669 0.024725119182394978 0.06233200938255188 1.9207393359353184e-07 6.716531569363248 0.13368602545473984 APCCGADVK(ub)AHHEVCPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 APCCGADVKAHHEVCPK 17 1 Q12933-3;Q12933;Q12933-2;B1AMX8 Q12933-3 TRAF2 TNF receptor-associated factor 2 1 19299000.0 1070500.0 3133500.0 15095000.0 True False 1624026.76403305 2574302.4428527537 12111466.633626478 1.0 1.585135479208374 7.4576767463790405 20.631143977721393 -6.92613624085153 0.7778469416149555 0.8967568757209344 8.552672686893619 0.9957230001871153 0.19070682755862117 0.09469408715454822 0.08787471505537887 0.16990448454942925 0.5430882386433695 1.1853968235544576e-07 6.92613624085153 7.655915811172684 up APCCGADVK(ub)AHHEVCPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APCCGADVKAHHEVCPK 17 1 Q12933-3;Q12933;Q12933-2;B1AMX8 Q12933-3 TRAF2 TNF receptor-associated factor 2 1 2018890.0 734860.0 681710.0 602320.0 True False 1006557.6008447915 651589.7980864942 460064.4211697859 1.0 0.6473447694792854 0.4570671571936464 19.940998303009508 -11.432623018941877 0.10191027834805838 2.106369059310079 2.4493167915496215e-13 0.999870776349335 0.002556937128964391 4.232637931599354 0.06710616762432783 1.3730788230484434 0.31571837120687213 3.69298021599454e-12 11.432623018941877 -2.106369059309834 APCCGADVK(ub)AHHEVCPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APCCGADVKAHHEVCPK 17 1 Q12933-3;Q12933;Q12933-2;B1AMX8 Q12933-3 TRAF2 TNF receptor-associated factor 2 1 15242000.0 1070500.0 2895500.0 11276000.0 True False 1385783.352709724 2734362.8796509407 9223883.701530438 1.0 1.9731532164131138 6.656079165256459 20.402270299813843 -6.940663136279361 0.653364492848413 0.9479769736082929 7.943940657652236 0.9982494835073937 0.10330506785723394 0.08746538634006382 0.05324158777313013 0.10107240069946538 0.4018869159418666 1.1464018116990091e-07 6.940663136279361 6.995963684043943 APDFVFYAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 APDFVFYAPR 10 0 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 24807900.0 5075000.0 7181900.0 12551000.0 False True 6653374.146369905 6110388.514826938 11252342.917693302 1.0 0.9183894337523132 1.6912235311210635 22.66565473395286 -6.8807979318555965 1.0753102101087104 0.9488620022488797 1.7468451912254817 0.9743246063694379 0.05555143593342839 0.12692691810660472 0.26801919505849525 0.03976572082162984 0.09636393574666986 1.315836921199676e-07 6.8807979318555965 0.7979831889766019 APDFVFYAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 APDFVFYAPR 10 0 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 17144000.0 4119700.0 2706300.0 10318000.0 False True 3988922.37850977 3786939.7031680574 7615406.266634989 1.0 0.9493640998305983 1.9091387457582076 21.927567619239955 -6.894446863471393 0.9956707458468536 0.9537921709933554 1.9992661467718604 0.983596359547279 0.0564807846386081 0.1156105295871062 0.2013490558284205 0.04294874837292475 0.1089399851853162 1.2751261038366474e-07 6.894446863471393 1.045473975778505 APDFVFYAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APDFVFYAPR 10 0 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 21775200.0 5075000.0 8038000.0 8662200.0 False True 6951364.646718169 7682854.581888537 6616366.7636089185 1.0 1.1052296883196473 0.9518083282730094 22.72886479547575 -6.722112745219383 1.7516955934231928 1.063876667268362 0.9520187574392229 0.5224273284976821 0.04427011989965562 0.35125397275134584 2.1074824503190013 0.020058002599125564 0.05022873019785337 1.8962135899039333e-07 6.722112745219383 -0.11185790982913901 APDFVFYAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APDFVFYAPR 10 0 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 10229400.0 4119700.0 3364900.0 2744800.0 False True 3425713.0836547483 3346772.6158196405 3318724.989478707 1.0 0.9769564858739164 0.9687691025011644 21.70797289467423 -13.999999999999998 0.14414278741380465 1.1105439135687747 0.9591252426495399 0.999586756337672 0.0002687212677666066 11.940536481152188 0.11923683903039096 0.3704938055755251 0.008647733375935728 1.0000000000000041e-14 13.999999999999998 -0.15141867091923478 APDK(ub)EAILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 APDKEAILR 9 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 7539030.0 2379350.0 2353880.0 2805800.0 True False 3119350.891658178 2002690.2793523737 2515482.7311340845 1.0 0.6420214810420984 0.806412237193652 21.57281441802262 -10.065109761838352 4.673959184567267 1.0000107418550142 0.7242168591134532 0.7895839214948271 0.06711224519465626 93109086.1806622 0.028027529711184954 11798.315564246852 0.02297430660702187 8.607761755869689e-11 10.065109761838352 -0.2757938827415609 APDK(ub)EAILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 APDKEAILR 9 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 9768830.0 2550170.0 2700760.0 4517900.0 True False 2469216.249242482 3779187.552277342 3334526.4559052363 1.0 1.5305210928515232 1.3504392160582204 21.235621759813757 -10.155948891580888 6.023132070814849 0.999996369644155 1.440480154454876 0.8886069043961693 0.07351811834440847 3.585171888047896e-06 5.02442855004098e-07 0.07118419839639939 0.0237278706660306 6.983145779377182e-11 10.155948891580888 0.44048378481072104 APDK(ub)EAILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APDKEAILR 9 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 7695070.0 2379350.0 2421620.0 2894100.0 True False 3259059.9945160383 2314624.8211735394 2210573.1858604676 1.0 0.7102124002222472 0.6782855147128802 21.63602447954551 -13.999999999999998 0.31144496029611834 3.8249866302429445 0.6713239720025858 0.9996751667001131 0.0026083115902881073 17.373344840843973 0.17762294984116028 31.8310641896389 0.010998768210146516 1.0000000000000041e-14 13.999999999999998 -3.153662658240359 APDK(ub)EAILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APDKEAILR 9 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 8427480.0 2550170.0 5085800.0 791510.0 True False 2120579.346686366 5058401.785947742 957011.081471253 1.0 2.3853867075768895 0.4512969924783461 21.016027035248033 -6.714426418167256 1.77941972274389 1.8478189461098558 0.4552179214535887 0.4861214805450048 0.5834064772390603 0.36623614547139 2.263106087349786 0.2606488464314991 0.6586423816190293 1.9300723176137475e-07 6.714426418167256 -1.392601024656267 APDK(ub)EAILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APDKEAILR 9 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 13057800.0 2887200.0 7083500.0 3087100.0 True False 3737537.315220471 6689296.998103066 2525279.476320916 1.0 1.7897605920513668 0.6756533148276953 21.833656552438203 -6.716320488407651 1.7725674412317356 1.482381587410956 0.6777550802976298 0.49497107482361413 0.33249671176469087 0.36258127522513395 2.2243648370045275 0.14905760080411004 0.3758177227270175 1.9216731033527196e-07 6.716320488407651 -0.8046265071133263 APDQAAEIGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APDQAAEIGSR 11 0 Q3ZCQ8;Q3ZCQ8-2;M0R003;M0QXC3;M0R2Z3;M0R303;M0R2D2;M0R1Y4 Q3ZCQ8 TIMM50 Mitochondrial import inner membrane translocase subunit TIM50 0 43694500.0 19804000.0 20309000.0 3581500.0 False True 16467903.465955945 20199591.385979135 4330375.09101501 1.0 1.2266037038495945 0.26295849377348995 23.97315356100043 -6.8447307328894365 1.2602959164283216 1.1205769700513961 0.22818815049857155 0.9322741586880164 0.10706147056157563 0.16334948411853417 0.5019465044177083 0.0665545891693934 0.15357583557679572 1.4297801623750595e-07 6.8447307328894365 -0.8923888195528246 down APEFPSYK(ub)ECCSQCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 APEFPSYKECCSQCK 15 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;A0A0A0MRS6;Q86UV5-5 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 8718600.0 2768400.0 2714500.0 3235700.0 True False 3629399.2092237375 2309507.181038125 2900900.8030260717 1.0 0.6363331912259073 0.7992785129984424 21.791299321509737 -10.121824412949932 5.104156336259116 1.0000092939964091 0.7178058521116852 0.7999598236379492 0.06652214905442513 7.035705975915617e-06 1.2104870948866608e-06 0.06441191423784125 0.02146993128656516 7.553975762897808e-11 10.121824412949932 -0.2822034418847239 APEFPSYK(ub)ECCSQCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APEFPSYKECCSQCK 15 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;A0A0A0MRS6;Q86UV5-5 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 8973900.0 2768400.0 2328600.0 3876900.0 True False 3791952.2931969655 2225714.7523495476 2961256.0672618244 1.0 0.5869574773771916 0.7809317834969944 21.854509383032628 -10.043472214914235 4.875853762653785 1.0000068528863306 0.6839446304330294 0.7797251649772692 0.07918967888135248 5.899349251102287e-06 1.1573947696301693e-06 0.0766767388309218 0.02555835895625023 9.047483194441184e-11 10.043472214914235 -0.3160622224533012 APEPHVEEDDDDELDSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 APEPHVEEDDDDELDSK 17 0 P52566;F5H3P3;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 26751500.0 1377000.0 15388000.0 9986500.0 False True 1805260.33488697 13092170.381954204 8953192.777272267 1.0 7.252234001349132 4.95950229684343 20.783775471127925 -10.62858691411042 8.705931407718598 0.9970175503151321 6.105868149205759 0.8686386259511638 0.9360037988567514 0.054021767023745504 0.002304675456139487 0.9035755059503956 0.302093927079923 2.3518687735290125e-11 10.62858691411042 5.108850598890627 APEPHVEEDDDDELDSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 APEPHVEEDDDDELDSK 17 0 P52566;F5H3P3;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 25895300.0 6534700.0 1817600.0 17543000.0 False True 6327259.525413942 2543377.1586587857 12947962.021281017 1.0 0.40197136666247196 2.0463775777292676 22.593149341460933 -6.808323350418583 1.4217275922273291 0.6734247172171893 2.0740083699262586 0.8553497714714657 0.25846888141766305 0.20910751006078568 0.8333831805099909 0.14296679887085717 0.3309457569805544 1.554807581231498e-07 6.808323350418583 1.4005836527090691 up APEPHVEEDDDDELDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APEPHVEEDDDDELDSK 17 0 P52566;F5H3P3;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 24271000.0 1377000.0 12019000.0 10875000.0 False True 1886114.1120257995 11487960.838482002 8306548.977655432 1.0 6.09080901586768 4.404054306520034 20.846985532650816 -10.265417454725522 6.503760098169814 0.999929111179094 5.247431661193858 0.8942302052888879 0.6886147265230499 0.0007078266223956652 7.995250425414565e-05 0.6667587086924107 0.22224944731474505 5.427283965659842e-11 10.265417454725522 4.247502550014763 APESK(ub)SGSGSESEPSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 APESKSGSGSESEPSSR 17 1 I3L2N2;O14641;I3L0Z8 I3L2N2 DVL2 Segment polarity protein dishevelled homolog DVL-2 1 4662470.0 597870.0 1595800.0 2468800.0 True False 578890.9441074928 2233011.261987064 1822147.2175875634 1.0 3.857395394964793 3.1476519647355437 19.142932062350294 -10.060898283161173 6.709162994976743 0.999998749066117 3.502523679850172 0.9431057931775999 0.28975154205906417 5.428393969595527e-06 7.61438459476292e-07 0.2805508662642101 0.0935169080777206 8.6916397380083e-11 10.060898283161173 2.5025249307840554 APESK(ub)SGSGSESEPSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 APESKSGSGSESEPSSR 17 1 I3L2N2;O14641;I3L0Z8 I3L2N2 DVL2 Segment polarity protein dishevelled homolog DVL-2 1 12812780.0 920680.0 2865600.0 9026500.0 True False 1396738.8707239127 2354211.2909650076 7242408.318544502 1.0 1.6855056734727005 5.185227153298061 20.413630894205063 -6.9393412093505304 0.665663232180363 0.9602354787050351 6.110980127261603 0.9980763453207454 0.08038791894810837 0.08806844613546216 0.05598778358581221 0.07786645616973546 0.3020988265159947 1.1498966020919548e-07 6.9393412093505304 5.150744648556568 APEVNLNAPDVDVHGPDWNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 APEVNLNAPDVDVHGPDWNLK 21 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 20398600.0 4518400.0 3837200.0 12043000.0 False True 4374965.865247113 5369413.970733645 8888577.017744254 1.0 1.2273041975906622 2.0316905986287503 22.06084032998781 -6.947690961309905 0.5836423297708782 0.990510286838163 2.308520536219571 0.999007407268662 0.013944454052644202 0.08442638100512076 0.03990318176313795 0.014553206589539389 0.06726300102566159 1.1279998416748267e-07 6.947690961309905 1.318010249381408 up APFAAHGYGAFLTLSILDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 APFAAHGYGAFLTLSILDR 19 0 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 30256300.0 22171000.0 4218700.0 3866600.0 False True 21467193.740791816 5903248.910229869 2853821.4644864155 1.0 0.2749893153948928 0.13293872962368636 24.3556302740923 -13.999999999999975 0.2291700979509335 5.5592700960931545 0.06332488457126051 0.9995086718700458 0.00841661064917861 13.265549002151444 0.15158248560936477 27.507675413442016 0.07411945825830067 1.0000000000000573e-14 13.999999999999975 -5.495945211521894 APFAAHGYGAFLTLSILDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 APFAAHGYGAFLTLSILDR 19 0 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 1594172500.0 412512500.0 548910000.0 632750000.0 False True 625811621.2033482 450952721.8465945 507686685.1558224 1.0 0.7205886029720502 0.8112452181370681 29.22115320850031 -10.556675748465636 9.042894836472904 1.000022931657971 0.7659169105545591 0.8988831709824732 0.03701040816035887 1.7112432793742523e-05 8.389146896782875e-07 0.03583867612426283 0.011945057870117405 2.7753914850608702e-11 10.556675748465636 -0.23410602110341183 APFAAHGYGAFLTLSILDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APFAAHGYGAFLTLSILDR 19 0 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 36118100.0 22171000.0 7361800.0 6585300.0 False True 18436168.84183542 7322140.5221971115 7962255.783013025 1.0 0.3971617197159577 0.4318823423305305 24.136035549526575 -9.950396421324543 5.556829860674432 1.0000008610771105 0.4145220310222594 0.997369300600856 0.014174634829710962 1.5120956758633164e-07 2.855969198672536e-08 0.013724551197409136 0.004574843718999567 1.1209947500635319e-10 9.950396421324543 -0.5854788300548511 APFAAHGYGAFLTLSILDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APFAAHGYGAFLTLSILDR 19 0 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 1074702500.0 412512500.0 285200000.0 376990000.0 False True 534005563.0870346 269328369.2890515 308381688.2440549 1.0 0.504354987862093 0.5774877820772693 28.99227953059276 -10.648365732119336 6.6210158104289425 1.0021563090993477 0.5409213849697453 0.9813223101011976 0.0298563382151912 0.0009537603585501113 5.0653022002727464e-05 0.029012651291862184 0.00963609172384763 2.247161408266886e-11 10.648365732119336 -0.46123492412960243 APFAAHGYGAFLTLSILDRYYTPTISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 APFAAHGYGAFLTLSILDRYYTPTISR 27 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 30497800.0 9639200.0 10904000.0 9954600.0 False True 14623371.119913481 8958096.006659152 7987068.946743821 1.0 0.6125876128836257 0.54618520457758 23.801772597755527 -13.999999999999998 0.24813624798090803 3.6691706577574834 0.5190084736212656 0.9995392206895615 0.0042958058598954905 13.924907717283824 0.15763017676956056 18.505553694365894 0.030965177107451836 1.0000000000000041e-14 13.999999999999998 -3.1501621841362177 APFAAHGYGAFLTLSILDRYYTPTISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APFAAHGYGAFLTLSILDRYYTPTISR 27 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 25198500.0 9639200.0 5465300.0 10094000.0 False True 12478134.417038372 5161151.250615189 8256995.573186257 1.0 0.4136156157740898 0.6617171523582623 23.572898919847976 -10.335461621556446 5.815556330044933 1.0000631386218997 0.5376663840661846 0.8223833958820719 0.10128702817195095 8.292800610827228e-05 9.476063406981002e-06 0.09808406535563265 0.032690247774733214 4.618898071240983e-11 10.335461621556446 -0.46239675455571505 APFDLFENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 APFDLFENK 9 0 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 36633600.0 1627600.0 14524000.0 20482000.0 False True 2133799.361700822 12357075.81410858 18362719.117217287 1.0 5.791114214346247 8.605644676255135 21.02499309717931 -8.400353725117352 0.34629474169004 8.69486682263991e-18 9.702746908623794 0.9979989559989207 0.140450466521692 0.1443565533739551 0.09673604748748935 0.8382302883160192 0.7822698703794411 3.977830513690308e-09 8.400353725117352 9.702746908623794 APFDLFENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 APFDLFENK 9 0 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 27494300.0 10026000.0 2740300.0 14728000.0 False True 9707730.117954932 3834516.0804757187 10870294.969470832 1.0 0.3949961560410079 1.119756610184875 23.210702570386335 -6.685206354730041 1.8834427709488106 0.6190083591491018 1.1171167950325598 0.3480727260487534 0.2561287202328805 0.4270653012905637 2.93331352677841 0.10894460457322472 0.28542619042204986 2.0643990249333846e-07 6.685206354730041 0.498108435883458 APFDLFENK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APFDLFENK 9 0 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 32927600.0 1627600.0 15085000.0 16215000.0 False True 2229367.7042361586 14418494.820575835 12385350.958407633 1.0 6.4675265516668095 5.555544262560844 21.0882031587022 -10.334461370665952 6.290253222525364 0.9996737396544877 6.011535407113828 0.975765289774665 0.37231521046083504 0.001703585950176977 0.0001802436236083199 0.36050797743164475 0.12016421747120973 4.6295484054268575e-11 10.334461370665952 5.011861667459341 APFDLFENK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 APFDLFENKK 10 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 14871500.0 5274300.0 5843400.0 3753800.0 True False 6914658.376393859 4971587.497394797 3365392.7849922003 1.0 0.7189924977880954 0.48670412937266816 22.721226545087905 -7.063483914365117 0.1668564647749814 1.22035844450653 2.108635523278514e-12 0.9999975938570409 0.00032548849634871123 0.07327929137652099 0.005433526187949944 0.010922499131786776 0.027549048237465092 8.640046615656453e-08 7.063483914365117 -1.2203584445044215 down APFDLFENK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 APFDLFENKK 10 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 20044600.0 5527600.0 8666200.0 5850800.0 True False 5352129.363655266 12126658.853635967 4318299.959762356 1.0 2.265763405493248 0.8068377399632115 22.351681556388826 -6.677326817738416 1.911622629022649 1.8028044947751876 0.8125404870641916 0.3117670159029071 0.5367821411698054 0.44452714963973505 3.1383852845312297 0.22552134065859689 0.5967903069851621 2.1021958880532195e-07 6.677326817738416 -0.990264007710996 APFDLFENK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 APFDLFENKK 10 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 22189200.0 0.0 7332200.0 14857000.0 True False 0.0 6023711.6232599225 11920507.437945563 0.0 APFDLFENK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APFDLFENKK 10 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 14085700.0 5274300.0 4230900.0 4580500.0 True False 7224351.242598165 4043964.848284669 3498680.2383586913 1.0 0.5597685816325699 0.48428988581408267 22.784436606610797 -13.999999999999998 0.24809273730888243 4.0324196622729405 0.45338569520180416 0.9995391407524592 0.004882055188338759 13.923199689627733 0.15761630099739293 21.017176638410113 0.03520629011967923 1.0000000000000041e-14 13.999999999999998 -3.5790339670711364 APFDLFENK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APFDLFENKK 10 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 24401900.0 5527600.0 12619300.0 6255000.0 True False 4596444.314200059 12551317.32616507 7562891.580147659 1.0 2.7306579756420777 1.645378702137908 22.132086831823102 -10.258602582287436 4.97375652231466 0.9997560544527124 2.18801833889081 0.6150477697450419 0.4430634080867726 0.0011987560340341564 0.00017868806172686603 0.4290789654652974 0.14299810006909264 5.5131196466387855e-11 10.258602582287436 1.1882622844380977 APFDLFENKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 APFDLFENKK 10 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 10888200.0 2783000.0 1907700.0 6197500.0 False True 2694655.1883371803 2669454.558524075 4574188.828985296 1.0 0.9906479204010306 1.6975043221793211 21.361669244935598 -6.903905292349689 0.9362743574926479 0.9736763247070293 1.7778702058767486 0.9884102190141021 0.035637638533541745 0.10858715360757835 0.16166242281965248 0.028324793187248617 0.07524829473386573 1.2476555638514802e-07 6.903905292349689 0.8041938811697193 APFDLFENR ddPTM_RPMI8226_Bortezomib_1h_R1 1 APFDLFENR 9 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 19084300.0 1009500.0 9383500.0 8691300.0 False True 1323464.2760119075 7983518.376596526 7792007.6488365615 1.0 6.032288533434277 5.887584417704717 20.335887822324434 -10.123873602361492 4.522687484969723 0.9994610602697825 5.959936475719499 0.999362039686562 0.05907520838150167 4857664.460062563 29.84407407510561 27357.096713388342 0.021316929582884316 7.518416791722991e-11 10.123873602361492 4.960475415449717 APFDLFENR ddPTM_RPMI8226_Bortezomib_2h_R1 1 APFDLFENR 9 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 16898200.0 5976400.0 2520200.0 8401600.0 False True 5786682.453315959 3526529.002669382 6200968.917402643 1.0 0.6094215521794469 1.0715930876506423 22.464305047094705 -6.682677340412616 1.8921659764804348 0.7534779550582921 1.0698820660978838 0.33653228493282494 0.16543949634504967 0.432591338796129 2.9966613531471444 0.07009566706918205 0.18425505550990504 2.0764556496448588e-07 6.682677340412616 0.31640411103959176 APFDLFENR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APFDLFENR 9 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 22625500.0 1009500.0 10158000.0 11458000.0 False True 1382739.4307117246 9709185.971986024 8751856.384917336 1.0 7.021703262623027 6.329360536433516 20.399097883847325 -9.714204517422722 6.445034436709043 0.9999999706903676 6.675531899534058 0.9889625125459094 0.2826477344026989 1.1922363409406143e-07 2.277867813006548e-08 0.2736724920370021 0.09122416401235194 1.9310587310630386e-10 9.714204517422722 5.67553192884369 APGEQTVPALNLQNAFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 APGEQTVPALNLQNAFR 17 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 7416560.0 830760.0 1780500.0 4805300.0 False True 804387.9785350331 2491462.9351848373 3546647.7740900507 1.0 3.097339843047304 4.40912578100592 19.617531995367138 -8.400655378323467 0.2478258947903687 4.923396214749105e-15 5.481880690693777 0.9993892303805562 0.034698903067210886 0.12840374376301003 0.06276119291333349 0.5455925471258685 0.4985563329210709 3.975068542836626e-09 8.400655378323467 5.481880690693772 APGFGDNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 APGFGDNR 8 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 12713100.0 4133700.0 1704800.0 6874600.0 False True 4002477.9561729785 2385535.5304145548 5073936.026420705 1.0 0.5960146580533614 1.2676986811620607 21.932462026379884 -6.743893671120447 1.6729805059342204 0.7607130838863218 1.268393603267504 0.6220672494817027 0.1697291162574386 0.3108157016018204 1.7096241324848627 0.08022182846452999 0.19598100187674491 1.803459230067371e-07 6.743893671120447 0.5076805193811823 APGPLSK(ub)QGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 APGPLSKQGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVK 42 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 34659200.0 12074000.0 14249000.0 8336200.0 True False 15829130.92478234 12123104.742166983 7473649.990476844 1.0 0.7658730475964954 0.47214531397778625 23.916078712805685 -6.968056252514228 0.30101793427668905 1.0503298811623216 0.17847144745975174 0.9999630019832241 0.0013135440144650973 0.07693860578819015 0.011275796094692064 0.004848596250715097 0.02631484412044068 1.0763257922100808e-07 6.968056252514228 -0.8718584337025699 down APGPLSK(ub)QGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVK ddPTM_RPMI8226_Bortezomib_2h_R1 2 APGPLSKQGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVK 42 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 86077600.0 25668700.0 27024800.0 33384100.0 True False 24853861.16883602 37815943.57247022 24639802.708467655 1.0 1.5215319388637774 0.9913873156804799 24.566966663138253 -10.766402763944779 2.9921680318980988 0.9487096628453617 1.2564596273457103 0.23781882722757963 0.21643063677966642 73929481.35091141 76571433.05604963 28163193.11410634 0.07814938026332868 1.7123685233235932e-11 10.766402763944779 0.3077499645003485 APGPLSK(ub)QGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 APGPLSKQGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVK 42 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 52988200.0 15138000.0 21103900.0 16746300.0 True False 20734927.68906791 20171459.916735202 12791168.840874596 1.0 0.9728251874912597 0.6168899661810006 24.305559680213307 -6.922170684088615 0.808473887393019 1.007256224752429 0.5565270320880543 0.9947627201180245 0.012631840227758064 0.09691149344486893 0.09912219788938013 0.011010607738698216 0.033698152719225175 1.1962702871729528e-07 6.922170684088615 -0.4507291926643747 APGPLSK(ub)QGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 APGPLSKQGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVK 42 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 93900600.0 25668700.0 45499400.0 22732500.0 True False 21344661.36621809 45254285.7012762 27485760.64679563 1.0 2.120168829330764 1.2877112536578808 24.34737193857253 -10.065174253316876 4.433298770777289 0.9999537027985009 1.7039400408506118 0.4880782393054559 0.33984938236163953 44576530.33296577 25301175.87504427 20223.61394014932 0.1163394830749695 8.606483622966358e-11 10.065174253316876 0.7039863380521109 APGPLSK(ub)QGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 APGPLSKQGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVK 42 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 147928500.0 44557000.0 39382500.0 63989000.0 True False 57679914.849777795 37190829.25500019 52343658.58258522 1.0 0.6447795450437191 0.9074850182929296 25.78156569900709 -9.920445040318965 5.464100038151471 1.0000001372264915 0.7761322816752426 0.49193211925171265 0.10724906035245681 3.6928288260772746e-07 7.292206127956789e-08 0.10384358768585529 0.034614485386358265 1.2010330533409046e-10 9.920445040318965 -0.22386785555124888 APGTPHSHTK(ub)PYVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 APGTPHSHTKPYVR 14 1 J3QQ67;Q07020;F8VYV2;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 11660000.0 2447800.0 2343100.0 6869100.0 True False 3713491.5581504917 1924955.498276143 5511419.374166517 1.0 0.5183680824724614 1.48416100800603 21.824344867971533 -6.7711485395563376 1.5704181774919757 0.7241505416566681 1.4897838457254358 0.7348072841816563 0.20304377831688591 0.2645759017440664 1.2879495693539416 0.1019096222968084 0.24229675301955883 1.6937583937065417e-07 6.7711485395563376 0.7656333040687676 APGTPHSHTK(ub)PYVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APGTPHSHTKPYVR 14 1 J3QQ67;Q07020;F8VYV2;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 4016870.0 905170.0 1237900.0 1873800.0 True False 1239835.8102994869 1183205.48481212 1431247.0321223708 1.0 0.9543243347087325 1.154384330757996 20.241717648524585 -6.846663765788933 1.250998784035025 0.9756775561156581 1.1618853110584155 0.9353187962577181 0.021769979628700156 0.16116667865335949 0.48703652770256717 0.013627649601349693 0.03147680799379707 1.423430391661263e-07 6.846663765788933 0.18620775494275743 APGTPHSHTK(ub)PYVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APGTPHSHTKPYVR 14 1 J3QQ67;Q07020;F8VYV2;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 13948500.0 2447800.0 2870000.0 8630700.0 True False 3168725.353351577 2710281.977067242 7060001.1584603395 1.0 0.8553224640313376 2.228025584796404 21.595471190063982 -6.880858501222312 1.0750557172834523 0.9092849749805099 2.3269021021097442 0.9743689584971491 0.09859357422293218 0.12686977925345047 0.2677443496403228 0.07059382747742766 0.17108431580684857 1.315653419324997e-07 6.880858501222312 1.4176171271292344 up APIIAVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 APIIAVTR 8 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 196393000.0 47218000.0 63302000.0 85873000.0 False True 61903255.259762384 53857588.349263445 76987685.71198128 1.0 0.8700283712587134 1.2436774994936963 25.883511941561128 -6.812729369438452 1.4028578176995539 0.9293923992454537 1.2506421481330803 0.8668885308270098 0.05650641241930381 0.20309183341279136 0.7871870112208811 0.031666252466583604 0.0731701354163022 1.539113439915205e-07 6.812729369438452 0.3212497488876266 APIIAVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APIIAVTR 8 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 254544000.0 47218000.0 95956000.0 111370000.0 False True 64675770.61847062 91716346.6359413 85066699.73714818 1.0 1.418094376903307 1.3152792602807297 25.94672200308402 -10.072702252431064 5.033098736788954 0.999992109354078 1.3666868185936127 0.9443194453966858 0.041974095600544825 3.7165468198899725e-06 6.847923782122863e-07 0.04064211746322044 0.013547081101959593 8.458585578342208e-11 10.072702252431064 0.36669470923953473 APIICVLGHVDTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 APIICVLGHVDTGK 14 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 19626500.0 6939200.0 6720800.0 5966500.0 False True 9097358.399308393 5718082.837473218 5349143.814709349 1.0 0.6285432085327015 0.5879886863769164 23.1170162599687 -13.999999999999998 0.31275863001151216 4.649165844044594 0.5792704991912062 0.9996780423284483 0.0033267662910736605 17.468527166793628 0.17804736323548465 41.547342913048205 0.01389666727198093 1.0000000000000041e-14 13.999999999999998 -4.069895344853388 APIICVLGHVDTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 APIICVLGHVDTGK 14 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 8825800.0 4745200.0 1726000.0 2354600.0 False True 4594566.223391163 2415200.800971094 1737859.6235141256 1.0 0.525664596730631 0.37824237131823163 22.131497231294855 -13.999999999999998 0.16363052228765396 3.3548504874405785 0.23897155790867874 0.9995272934513205 0.005767432071655234 12.03587247266906 0.12794544967619068 8.993877242308395 0.12753673715258754 1.0000000000000041e-14 13.999999999999998 -3.1158789295319 APIICVLGHVDTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APIICVLGHVDTGK 14 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 20721600.0 6939200.0 6803800.0 6978600.0 False True 9504809.764828919 6503185.618842155 5330398.408778503 1.0 0.6841994505672475 0.5608106359480038 23.180226321491592 -13.999999999999208 0.12994008600768947 2.500745176279309 0.3878815384713245 0.9996458871425646 0.003480270425999144 11.936796451419088 0.11209219101620745 4.575513457962187 0.15378745293581136 1.0000000000018242e-14 13.999999999999208 -2.1128636378079846 APIICVLGHVDTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APIICVLGHVDTGK 14 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 10655700.0 4745200.0 882800.0 5027700.0 False True 3945844.048003137 878044.1811779201 6078968.82454171 1.0 0.22252379224725558 1.5406003761395684 21.91190250672913 -6.74685794424753 1.661361513411082 0.5411209257104733 1.5426234612761616 0.6353977696559248 0.32666297294695257 0.3055523536632919 1.6582841621734725 0.1553873662384818 0.3785079526290333 1.79119164887743e-07 6.74685794424753 1.0015025355656881 APIICVLGHVDTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APIICVLGHVDTGK 14 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 28869700.0 9619300.0 11753000.0 7497400.0 False True 12452373.474750726 11098935.218282683 6132950.12982035 1.0 0.8913108204462092 0.4925125432718456 23.569917416456565 -6.946860054963702 0.5923151786351586 1.0045788324337415 0.3590976393006454 0.9989312586065884 0.007132439383728067 0.0847716617264434 0.04137345682305535 0.007376930880061022 0.03343276143283118 1.1301600335226152e-07 6.946860054963702 -0.645481193133096 down APILIATDVASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 APILIATDVASR 12 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;A0A0U1RQJ0;J3KTA4;P17844;P17844-2 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 86867000.0 17439000.0 28875000.0 40553000.0 False True 22862697.879516255 24566962.55386842 36356964.571844146 1.0 1.0745434630389397 1.5902307227012795 24.446492320946003 -6.932902238474106 0.7225690187050886 0.9929401170192915 1.7043741025353285 0.9970786186449336 0.014184710513895646 0.09115841210531564 0.07050032809704168 0.013153777308520622 0.0459387874093152 1.1670723004083833e-07 6.932902238474106 0.711433985516037 APILIATDVASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 APILIATDVASR 12 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;A0A0U1RQJ0;J3KTA4;P17844;P17844-2 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 69691000.0 24058000.0 11781000.0 33852000.0 False True 23294291.9586834 16485214.737103412 24985145.66176855 1.0 0.7076933167293898 1.0725866107492847 24.473473143907945 -6.693351308253102 1.8541085052105222 0.8173293703919142 1.0713943641735009 0.38639324940917497 0.1235410290467497 0.4094739065770051 2.731626609666417 0.05324826382344236 0.13809964392063265 2.026043155426677e-07 6.693351308253102 0.25406499378158665 APILIATDVASR ddPTM_RPMI8226_Bortezomib_8h_R1 1 APILIATDVASR 12 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;A0A0U1RQJ0;J3KTA4;P17844;P17844-2 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 227424000.0 30554000.0 196870000.0 0.0 False True 46352651.7966051 161737010.34766918 0.0 1.0 3.4892720066452574 0.0 25.466148540805083 -6.715173099405554 1.7769464657147853 2.522197774087679 0.006945335574872712 0.4895734264516619 1.048158461260256 0.36475898967541115 2.248190921673553 0.4688810492238721 1.1836850792770355 1.9267568008932738e-07 6.715173099405554 -2.5152524385128063 APILIATDVASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APILIATDVASR 12 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;A0A0U1RQJ0;J3KTA4;P17844;P17844-2 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 79057000.0 17439000.0 32143000.0 29475000.0 False True 23886669.57125485 30722815.97731317 22513612.05667992 1.0 1.286190855768563 0.9425178336193312 24.509702382468895 -6.6857015196738585 1.8818310391245283 1.1801417206089 0.943767443692121 0.35034759740055677 0.12114623151590963 0.4259596042628195 2.9211566002899243 0.05156793324163471 0.1350116327584383 2.0620466222540397e-07 6.6857015196738585 -0.23637427691677904 APILIATDVASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APILIATDVASR 12 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;A0A0U1RQJ0;J3KTA4;P17844;P17844-2 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 42392000.0 24058000.0 10614000.0 7720000.0 False True 20005292.950109452 10556820.275285948 9334216.306753 1.0 0.5277013589160258 0.4665873341635785 24.25387841934222 -13.999999999999998 0.2882740009405926 5.030469137569399 0.4496420382090171 0.9996236007623907 0.004624378915749661 15.863921571377425 0.17022862213636686 37.88008878266498 0.02326256116067381 1.0000000000000041e-14 13.999999999999998 -4.5808270993603815 APILIATDVASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APILIATDVASR 12 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;A0A0U1RQJ0;J3KTA4;P17844;P17844-2 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 107213000.0 30554000.0 48317000.0 28342000.0 False True 39552755.30938147 45628116.47594346 23184046.81347783 1.0 1.15360146515813 0.586155038558814 25.237274862897532 -6.834606046394556 1.3071038275063458 1.0818519344740323 0.5693863880298962 0.9147940952529297 0.06995175021419821 0.1751940661084888 0.5837315570854242 0.041996362404592744 0.09666140859387329 1.4635041342373908e-07 6.834606046394556 -0.5124655464441361 APIPQK(ub)QEILVEPEPLFGAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 APIPQKQEILVEPEPLFGAPK 21 1 O94888;C9JD50 O94888 UBXN7 UBX domain-containing protein 7 1 337242000.0 110990000.0 139250000.0 87002000.0 True False 145508964.82868883 118474442.79224882 77999867.62211402 1.0 0.8142071722641392 0.536048536349256 27.116532799623975 -6.965288950534255 0.3530594292270054 1.0259519055586332 0.31487348359682227 0.9999189761364975 0.0017161333126142042 0.07786305736681925 0.014515064582689991 0.003789486567766386 0.023860776530085108 1.0832059813235699e-07 6.965288950534255 -0.7110784219618109 APIPQK(ub)QEILVEPEPLFGAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 APIPQKQEILVEPEPLFGAPK 21 1 O94888;C9JD50 O94888 UBXN7 UBX domain-containing protein 7 1 534731500.0 197659200.0 185192300.0 151880000.0 True False 191384616.88917613 259140551.1550864 112098071.6976665 1.0 1.3540302003747002 0.5857214311146983 27.51189963265536 -6.781407568844569 1.5303504439818176 1.2000929815281767 0.579360225604376 0.7723561190278456 0.14980723696847054 0.24839069434386774 1.149095314328602 0.07709334108401537 0.18169780932545143 1.654216815266922e-07 6.781407568844569 -0.6207327559238007 APIPQK(ub)QEILVEPEPLFGAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 APIPQKQEILVEPEPLFGAPK 21 1 O94888;C9JD50 O94888 UBXN7 UBX domain-containing protein 7 1 742185700.0 211026200.0 353739500.0 177420000.0 True False 320142173.4817296 290611922.44567156 142352859.23405167 1.0 0.9077589474860508 0.44465512833214926 28.254137499916187 -6.939713731488176 0.6622223667628109 1.005224594892274 0.3208158966264445 0.9981261498783442 0.010518391099752252 0.08789750061433303 0.05520643114044306 0.010216782655867937 0.03990896447295158 1.1489106851762833e-07 6.939713731488176 -0.6844086982658295 down APIPQK(ub)QEILVEPEPLFGAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APIPQKQEILVEPEPLFGAPK 21 1 O94888;C9JD50 O94888 UBXN7 UBX domain-containing protein 7 1 341840000.0 110990000.0 120920000.0 109930000.0 True False 152026002.39197037 115577354.57103279 83966798.07941718 1.0 0.7602472784427916 0.5523186610072442 27.179742861146867 -6.972790519401609 0.17941861043140217 1.1619836606370233 0.14496276300087857 0.9999967627085061 0.0003290659128916785 0.07540718649645688 0.005654569858406534 0.008048404350649076 0.023375554409036308 1.0646564281245248e-07 6.972790519401609 -1.0170208976361448 APIPQK(ub)QEILVEPEPLFGAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APIPQKQEILVEPEPLFGAPK 21 1 O94888;C9JD50 O94888 UBXN7 UBX domain-containing protein 7 1 545482500.0 197659200.0 245987800.0 101835500.0 True False 164362382.58725908 244662614.89664444 123128832.21584778 1.0 1.4885560250792447 0.7491302467003321 27.292304908089637 -6.728517489087912 1.7285852642473136 1.2944912550101846 0.7496827458576842 0.5524260321858732 0.2054019680742699 0.3390120255466419 1.983804833525385 0.09419114268230747 0.23412674000047293 1.8684544328694506e-07 6.728517489087912 -0.5448085091525003 APIPQK(ub)QEILVEPEPLFGAPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APIPQKQEILVEPEPLFGAPK 21 1 O94888;C9JD50 O94888 UBXN7 UBX domain-containing protein 7 1 821591700.0 211026200.0 487445500.0 123120000.0 True False 273177575.84828866 460318729.4259689 100713423.3178812 1.0 1.685053130721134 0.36867383058488373 28.025263822008636 -6.7652381737663125 1.5924174586861464 1.3952941605423728 0.3625083728538433 0.7121753918848714 0.2883964573822785 0.2741659404105919 1.3712253361365854 0.14281106184881123 0.3414925461701886 1.7169665180957165e-07 6.7652381737663125 -1.0327857876885296 APIRPDIVNFVHTNLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 APIRPDIVNFVHTNLR 16 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 89213900.0 25712100.0 59262800.0 4239000.0 False True 33708812.09633057 50421021.244585045 3800388.943359248 1.0 1.4957816104731176 0.11274170482480295 25.00662245163661 -6.809785311070124 1.415557828064796 1.2702748004103614 0.08870318668921738 0.8592035284772692 0.21467337356820654 0.20711757911317033 0.8180354095575401 0.11924828010659062 0.27585700076192454 1.5495824494658162e-07 6.809785311070124 -1.181571613721144 down APIRPDIVNFVHTNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 APIRPDIVNFVHTNLR 16 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 189749700.0 61681800.0 47491400.0 80576500.0 False True 59723745.02191035 66454963.684379205 59471097.40681478 1.0 1.1127059038243405 0.995769729192252 25.83180129778743 -6.6545374731135665 1.9921576112601591 1.072870168561821 0.9962589378887213 0.2127233035679026 0.04805071571738791 0.4975104191472762 3.78955382624151 0.019526087308366115 0.05324423196638466 2.215452927637205e-07 6.6545374731135665 -0.0766112306730996 APIRPDIVNFVHTNLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 APIRPDIVNFVHTNLR 16 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 163676000.0 25899000.0 119545000.0 18232000.0 False True 39290676.470520325 98211260.74065185 14628437.208630536 1.0 2.4996072748795624 0.37231319291756676 25.227683671210567 -6.717262679033374 1.7688961357527093 1.914986486367512 0.37606888899972796 0.4996762582970986 0.6312612640758226 0.3606710025775278 2.203957340445232 0.2835068408898046 0.7140821589747601 1.9175086023682951e-07 6.717262679033374 -1.538917597367784 APIRPDIVNFVHTNLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APIRPDIVNFVHTNLR 16 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 162642200.0 25712100.0 55877000.0 81053100.0 False True 35218558.21337581 53408169.37947079 61910027.120993465 1.0 1.5164780186596813 1.7578807952870823 25.0698325131595 -10.764427012465934 0.15062850173525472 2.3020129571774848e-17 2.087081147170777 0.9996614001157156 0.005817017120749245 2.778693749708055 0.08394391394521536 1.2141059132825331 0.22308143148705314 1.7201764098081765e-11 10.764427012465934 2.087081147170777 APIRPDIVNFVHTNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APIRPDIVNFVHTNLR 16 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 68573500.0 61681800.0 3216300.0 3675400.0 False True 51291149.66705721 3198973.1535144374 4443909.146870461 1.0 0.062368911094403554 0.08664085667248463 25.612206573221705 -10.769251857807928 2.9335752729556437 1.1947404408763522 0.07450488275395074 0.9994844169198163 0.009908983729456101 11229664.297036339 9606710.145638788 15765731.70192286 0.0036235278577427194 1.7011716719388477e-11 10.769251857807928 -1.1202355581224015 APIRPDIVNFVHTNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APIRPDIVNFVHTNLR 16 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 103321000.0 25899000.0 47836500.0 29585500.0 False True 33526766.04561343 45174356.723336905 24201242.57286528 1.0 1.347411696728424 0.7218484043447345 24.998809993303016 -6.756000458390951 1.627882780724231 1.2028007026885459 0.720031607435262 0.6742871644221438 0.14604898134721234 0.2896894133113877 1.5121043283842994 0.07082545328790492 0.1708594886264118 1.7538786506496305e-07 6.756000458390951 -0.48276909525328393 APIVTVGVNNDPADVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 APIVTVGVNNDPADVR 16 0 Q9BPX3;H0Y9Z8 Q9BPX3 NCAPG Condensin complex subunit 3 0 7324700.0 2662600.0 2485400.0 2176700.0 False True 3490694.384655077 2114588.00801332 1951475.9643807677 1.0 0.6057786145097509 0.5590509363865714 21.73508262170521 -13.999999999999998 0.30089031534862354 4.61442641844828 0.5476592577477116 0.9996518159898548 0.0036903919662749484 16.646669858259813 0.17423237775339545 37.47804103250179 0.016822667839754293 1.0000000000000041e-14 13.999999999999998 -4.066767160700569 APIVTVGVNNDPADVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APIVTVGVNNDPADVR 16 0 Q9BPX3;H0Y9Z8 Q9BPX3 NCAPG Condensin complex subunit 3 0 8920300.0 2662600.0 2285300.0 3972400.0 False True 3647035.1740594683 2184327.8895234996 3034200.9341460625 1.0 0.5989324986663488 0.8319637155483566 21.7982926832281 -10.215899364908987 5.533854175697658 1.0000130335554906 0.7154481071073348 0.6653367493188342 0.09513459591685687 1.5298471772836686e-05 2.1677940432179804e-06 0.09211789196777383 0.03070455880283733 6.082759351724839e-11 10.215899364908987 -0.2845649264481559 APK(ub)APDATADTGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 APKAPDATADTGR 13 1 Q9NTJ4-2;Q9NTJ4;Q9NTJ4-4;Q9NTJ4-3;A0A0C4DGU9 Q9NTJ4-2 MAN2C1 Alpha-mannosidase 2C1 1 6590200.0 1255400.0 2348400.0 2986400.0 True False 1904533.5820337124 1929309.6718670507 2396136.73101438 1.0 1.013009006544732 1.2581225942236842 20.8610062960316 -6.917881065927721 0.8403008836602879 0.9941677157670973 1.2957840244778525 0.9935715981237694 0.009519670839031736 0.09943461257758666 0.11219596750387181 0.008111432560529059 0.023826215905061753 1.2081446472526196e-07 6.917881065927721 0.3016163087107552 APK(ub)APDATADTGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APKAPDATADTGR 13 1 Q9NTJ4-2;Q9NTJ4;Q9NTJ4-4;Q9NTJ4-3;A0A0C4DGU9 Q9NTJ4-2 MAN2C1 Alpha-mannosidase 2C1 1 4392000.0 1255400.0 1516700.0 1619900.0 True False 1625140.047633616 1432294.31171355 1325094.8215776123 1.0 0.8813359278168852 0.8153726957298832 20.63213261812405 -13.999999999999998 0.0697387996992917 1.6882664609987568 0.5746864077946888 0.9999252936517543 0.0006602393443303085 12.362921419743685 0.07118326848631361 1.386584703774234 0.22178440144405437 1.0000000000000041e-14 13.999999999999998 -1.113580053204068 APKGKDAPKGAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 APKGKDAPKGAPK 13 3 Q14324 Q14324 MYBPC2 Myosin-binding protein C, fast-type 0 11740680.0 811580.0 2487000.0 8442100.0 False True 1063989.2393519008 2115949.294250074 7568592.474341384 1.0 1.9886942611740557 7.113410732378816 20.021052129550352 -6.939005193100452 0.6687539686941051 0.9413693045003027 8.455859094086334 0.998030681679783 0.1189049970515441 0.08822340962715848 0.05669838363445106 0.11489067334026708 0.44304237228957033 1.1507866282669725e-07 6.939005193100452 7.514489789586031 APKGKDAPKGAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 APKGKDAPKGAPK 13 3 Q14324 Q14324 MYBPC2 Myosin-binding protein C, fast-type 0 35988000.0 2468200.0 5340800.0 28179000.0 False True 2389848.342024374 7473409.291904068 20798074.548120506 1.0 3.127147928380071 8.70267547207746 21.188487638094415 -6.954440115276727 0.5077680794399002 0.8954741180960828 11.178026132805096 0.9995052179791862 0.07224636046579253 0.08175035250500799 0.028951829448192776 0.08353787696335001 0.46009672689625114 1.1106056658258311e-07 6.954440115276727 10.282552014709013 APKGKDAPKGAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APKGKDAPKGAPK 13 3 Q14324 Q14324 MYBPC2 Myosin-binding protein C, fast-type 0 9853480.0 811580.0 2133100.0 6908800.0 False True 1111643.0581248354 2038852.5887815899 5277083.731202382 1.0 1.8340892554313335 4.747102671701095 20.084262191073243 -6.947993640425588 0.5804524545525948 0.9652382576448184 5.760148062464919 0.9990342839169368 0.04991769291034352 0.08430153940282074 0.039374733228642565 0.052275130103918786 0.24337085261039162 1.127213962368621e-07 6.947993640425588 4.7949098048201 APKGKDAPKGAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APKGKDAPKGAPK 13 3 Q14324 Q14324 MYBPC2 Myosin-binding protein C, fast-type 0 19410200.0 2468200.0 11820000.0 5122000.0 False True 2052417.6597996575 11756323.3139137 6192986.5185477855 1.0 5.728036522089401 3.0174104617440785 20.96889291352869 -9.669028327428272 8.789992575578331 1.000018435313977 4.372723491916395 0.6736552119101954 1.1066084552739637 0.0 0.0 1.071469013523126 0.35715634316298794 2.1427508328230443e-10 9.669028327428272 3.3727050566024186 APKPDGPGGGPGGSHMGGNYGDDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 APKPDGPGGGPGGSHMGGNYGDDR 24 1 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 19770590.0 372590.0 11547000.0 7851000.0 False True 488469.09816669254 9824232.609853461 7038653.832109794 1.0 20.11229092428871 14.409619479568015 18.89790777085397 -9.525940952662005 7.163865327122679 1.0000000020055078 17.260955201954314 0.9155485274416805 2.3281058684620155 95528379.8311724 0.0 2.2541788141556682 0.7969725627482614 2.978921420582004e-10 9.525940952662005 16.260955199948807 APKPDGPGGGPGGSHMGGNYGDDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 APKPDGPGGGPGGSHMGGNYGDDR 24 1 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 19736200.0 4265400.0 1885800.0 13585000.0 False True 4129997.2117619137 2638809.7743170834 10026680.958735824 1.0 0.638937422718339 2.4277694256501214 21.977709376978915 -6.854186999485364 1.214783453794765 0.806405576118532 2.5052403926447266 0.9461695319965523 0.17919748373078198 0.1529130048682606 0.4321445628355382 0.1152953918046921 0.2676038009168442 1.3989848148696914e-07 6.854186999485364 1.6988348165261946 up APKPDGPGGGPGGSHMGGNYGDDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APKPDGPGGGPGGSHMGGNYGDDR 24 1 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 17320090.0 372590.0 9182400.0 7765100.0 False True 510346.59186615254 8776691.20586382 5931143.307254456 1.0 17.19751115368605 11.621794681858097 18.96111783237686 -9.502015086377334 7.501045829278752 1.0001973163003433 14.409652917780246 0.8852170637072003 2.2762767206152783 0.0 0.0 2.203995521945568 0.734665152091447 3.1476389705660105e-10 9.502015086377334 13.409455601479902 APLNETGEVVNEK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APLNETGEVVNEKAK 15 1 Q13535;Q13535-2 Q13535 ATR Serine/threonine-protein kinase ATR 1 21872100.0 2145800.0 3014300.0 16712000.0 True False 2777780.4000415937 2846551.555217344 13670587.479600646 1.0 1.024757592491732 4.921406846774477 21.405501119581665 -6.9082933729005696 0.9072749260216535 0.8727437963146475 5.407030105125091 0.9902615242450511 0.18185052369640278 0.10555749579633149 0.14496768558550976 0.1476384112628519 0.4028887776859239 1.2351128130260735e-07 6.9082933729005696 4.534286308810443 up APLNVQFNSPLPGDAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APLNVQFNSPLPGDAVK 17 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 6656400.0 1238600.0 2929900.0 2487900.0 False True 1696543.8919064293 2800447.3301163535 1900309.259908869 1.0 1.650677794707364 1.1201061575680578 20.694167324346015 -10.24095262488216 3.637295279804915 0.9993763931981792 1.3853919746567 0.41296876064932764 0.21660496648091618 77044256.37665482 135751325.99993706 588755.3218596551 0.07926929587610443 5.7417909325546167e-11 10.24095262488216 0.3860155814585209 APLTATAPQLDDEEMYSAHMPAHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 APLTATAPQLDDEEMYSAHMPAHLR 25 0 Q8WU39;H0Y9L3;D6RII0;Q8WU39-5;Q8WU39-4;Q8WU39-2 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 23004200.0 5699300.0 3117900.0 14187000.0 False True 5518378.841139094 4362893.729633707 10470999.099122945 1.0 0.7906114921122606 1.897477393371844 22.39581307158832 -6.8577618450266415 1.1970476200815385 0.8870060403216833 1.9488154321976408 0.9508529613226612 0.10643392918482476 0.1491281868923938 0.40733905773401086 0.06940964821205128 0.1616305409232526 1.3875164956112793e-07 6.8577618450266415 1.0618093918759575 APLVCLPVFVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 APLVCLPVFVSR 12 0 A0A1W2PRB8;Q9H0W9;Q9H0W9-2;E9PQS1;A0A087WT99;Q9H0W9-3;E9PJU8;Q9H0W9-4 A0A1W2PRB8 C11orf54 Ester hydrolase C11orf54 0 10160200.0 3145500.0 4369900.0 2644800.0 False True 4123780.961065328 3717927.9537367835 2371141.4667130318 1.0 0.9015823073144754 0.5749920980527725 21.975536273810707 -6.949163558544564 0.5679512638926044 1.004106641871193 0.45664492761434416 0.9991340046735468 0.0053456322801465886 0.08382334331883637 0.03736572772750313 0.005676694130124762 0.02719787123582767 1.1241815190799583e-07 6.949163558544564 -0.5474617142568489 APLVCLPVFVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APLVCLPVFVSR 12 0 A0A1W2PRB8;Q9H0W9;Q9H0W9-2;E9PQS1;A0A087WT99;Q9H0W9-3;E9PJU8;Q9H0W9-4 A0A1W2PRB8 C11orf54 Ester hydrolase C11orf54 0 17927600.0 3145500.0 6116800.0 8665300.0 False True 4308476.353941281 5846539.550447354 6618734.607455426 1.0 1.3569854097258982 1.5362123553030018 22.0387463353336 -11.47065500026815 0.11757733985373853 1.3440370253800623e-18 1.881299881779298 0.9997950247761763 0.0031909761658754894 4.302152579152756 0.07728993698118083 1.3587817307901713 0.2452858304969724 3.3833349864771168e-12 11.47065500026815 1.881299881779298 APLVLKD ddPTM_RPMI8226_Bortezomib_2h_R1 1 APLVLKD 7 1 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 8800180.0 2723600.0 897080.0 5179500.0 False True 2637140.8088232665 1255288.7222103977 3822833.5683306754 1.0 0.47600367716827646 1.449612988256203 21.33054317456819 -6.760518344507999 1.610515019002093 0.6958323046631532 1.4532627984916482 0.6930960969277098 0.22041054944079722 0.2820402103228628 1.4419192372842156 0.10797539134538295 0.2593496423694158 1.73572794453797e-07 6.760518344507999 0.757430493828495 APMILNGVCVIWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 APMILNGVCVIWK 13 0 Q13951-2;A0A494C0A9;Q13951;H3BSC0 Q13951-2 CBFB Core-binding factor subunit beta 0 17361400.0 5028400.0 7919900.0 4413100.0 False True 6592281.095094874 6738281.791528408 3956474.7454443737 1.0 1.0221472195022403 0.6001677853798244 22.65234632972353 -6.894516156925861 0.9952647965900651 1.020280206076282 0.5604896049628513 0.9836355732624711 0.02480613084076087 0.11555603299568856 0.20104655162909968 0.018868860784780825 0.047874182728690824 1.2749226685001596e-07 6.894516156925861 -0.4597906011134306 APMILNGVCVIWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 APMILNGVCVIWK 13 0 Q13951-2;A0A494C0A9;Q13951;H3BSC0 Q13951-2 CBFB Core-binding factor subunit beta 0 58651000.0 14359000.0 20560000.0 23732000.0 False True 21783652.783512928 16890907.36398678 19041359.79789487 1.0 0.7753937106806418 0.8741123441109208 24.376742556319535 -10.162114663081745 4.941316086983925 1.000012195169082 0.8247530274881408 0.8077610444733265 0.04030171333732677 5.633689242539169e-06 9.552527468211918e-07 0.03902479057314274 0.013007322047894707 6.884705013300806e-11 10.162114663081745 -0.17525916768094107 APMILNGVCVIWK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 APMILNGVCVIWK 13 0 Q13951-2;A0A494C0A9;Q13951;H3BSC0 Q13951-2 CBFB Core-binding factor subunit beta 0 34498680.0 8159680.0 7965200.0 18373800.0 False True 11176534.203060767 7613271.126605936 14034286.860289259 1.0 0.6811835393946177 1.255692203442269 23.41396954798923 -6.756081381093387 1.6273152816025773 0.8139152007835478 1.2573881399961033 0.6747511097191572 0.13402967249427247 0.2895404877885057 1.510249439030092 0.06501542844543741 0.15684697525819485 1.7535518784155546e-07 6.756081381093387 0.4434729392125555 APNGTGPLCSGK(ub)GHCQCGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APNGTGPLCSGKGHCQCGR 19 1 P26010 P26010 ITGB7 Integrin beta-7 1 5041250.0 419150.0 1857700.0 2764400.0 True False 574121.0821028412 1775620.6714076046 2111505.6546051204 1.0 3.0927634026327935 3.6778054672217912 19.130995507727206 -9.711384709249632 0.34563050139191154 4.06320164173997e-25 3.8171029854706156 0.9986214685513889 0.04268006083872164 1.0614871403466932 0.1467659619919176 1.3498765586570398 0.17449033464833735 1.9436375945288551e-10 9.711384709249632 3.8171029854706156 APNISMPDVDLNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 APNISMPDVDLNLK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9404300.0 1832700.0 3193300.0 4378300.0 False True 2402687.447892045 2716872.0873859064 3925275.5156192 1.0 1.1307638410353813 1.633702094320662 21.196217557906998 -6.945777178369236 0.6034360347599989 0.994375206175432 1.7959882735989705 0.9988267573797932 0.009356982458489305 0.08522722611157577 0.04333247220842216 0.009571227080203 0.04231353084727934 1.1329815081646874e-07 6.945777178369236 0.8016130674235386 APNISMPDVDLNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APNISMPDVDLNLK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5213100.0 1832700.0 0.0 3380400.0 False True 2510298.7168552494 0.0 2582019.1415233514 1.0 0.0 1.0285704741776505 21.25942761942989 -12.109672305779528 18.383399427061583 0.8914239561611093 0.5628567133799521 0.0 0.4915252587033531 0.0 0.0 0.0 0.14166638285640387 7.768330501273163e-13 12.109672305779528 -0.3285672427811571 APNTPDILEIEFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 APNTPDILEIEFK 13 0 P00966 P00966 ASS1 Argininosuccinate synthase 0 19078600.0 5004200.0 7772400.0 6302000.0 False True 6560554.660741732 6612788.216577906 5649929.493052599 1.0 1.0079617591099024 0.861196923921951 22.645386361678796 -6.894077616692268 0.9979307531991086 1.0071324035223377 0.8475164391338215 0.9833830229039457 0.008686700681059461 0.11589771686204292 0.20301235388039798 0.006594342346198136 0.016700736564939225 1.276210705278451e-07 6.894077616692268 -0.15961596438851622 APNTPDILEIEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 APNTPDILEIEFK 13 0 P00966 P00966 ASS1 Argininosuccinate synthase 0 31885900.0 9785400.0 5631500.0 16469000.0 False True 9474767.833257155 7880187.317884544 12155274.840590388 1.0 0.8317024181030048 1.282910046399707 23.175659161693684 -6.80572819354542 1.4327270335877647 0.9078056731213701 1.2900321382309279 0.8482892275948744 0.07251532419026013 0.21269179105250477 0.861295293012426 0.039809515195123386 0.09226531846655767 1.564126256506317e-07 6.80572819354542 0.3822264651095578 APNTPDILEIEFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APNTPDILEIEFK 13 0 P00966 P00966 ASS1 Argininosuccinate synthase 0 26793800.0 5004200.0 9147600.0 12642000.0 False True 6854387.973420113 8743428.784932021 9656219.97016277 1.0 1.2755958400424974 1.408764722336637 22.708596423201687 -12.564666730885621 0.10958102583664359 1.280773373252606e-19 1.6744069979297524 0.9997887183209492 0.0024742408526051305 7.162715470350685 0.08601848794183158 1.8110114922828282 0.21162923194330285 2.7247914578221937e-13 12.564666730885621 1.6744069979297524 APNTPDILEIEFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APNTPDILEIEFK 13 0 P00966 P00966 ASS1 Argininosuccinate synthase 0 22119300.0 9785400.0 5100900.0 7233000.0 False True 8136993.666722134 5073420.4392506275 8745386.858386576 1.0 0.6235006007193292 1.074768792576623 22.95606443712796 -6.685314180724913 1.883127939626414 0.7629304570046325 1.0731249232103715 0.3485803121199621 0.15938724241436383 0.4268078809335557 2.9306718474626727 0.06780583422643387 0.17761709825281383 2.0638865426031932e-07 6.685314180724913 0.310194466205739 APNTPDILEIEFK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APNTPDILEIEFKK 14 1 P00966 P00966 ASS1 Argininosuccinate synthase 1 28938300.0 1402700.0 3422600.0 24113000.0 True False 1815822.8013507032 3232129.301292797 19724681.420273438 1.0 1.779980567976441 10.862668651148777 20.79219199217008 -6.923833004569577 0.7957921727425767 0.8259009386491265 12.464694362400365 0.9951808708949735 0.3107793768808633 0.09596883653761014 0.09431316503083151 0.27335430465726934 0.8513874783200357 1.191700153898072e-07 6.923833004569577 11.638793423751238 up APNTPDILEIEFKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 APNTPDILEIEFKK 14 1 P00966 P00966 ASS1 Argininosuccinate synthase 0 8286200.0 1472500.0 3651100.0 3162600.0 False True 1930461.7597102826 3106370.111876334 2835364.4898013603 1.0 1.6091332015520101 1.4687493681443773 20.88051454571078 -10.169610996138857 4.613587302728545 0.9999244868981246 1.538941284851706 0.9515764906179413 0.05731146006559556 4.6882553396710824e-05 8.438258429213108e-06 0.05549972915493358 0.01849719418834466 6.766888240038736e-11 10.169610996138857 0.5390167979535813 APNTPDILEIEFKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 APNTPDILEIEFKK 14 1 P00966 P00966 ASS1 Argininosuccinate synthase 0 6954700.0 2511600.0 1684300.0 2758800.0 False True 2431870.632780332 2356849.7735084672 2036187.5177740438 1.0 0.9691509662312529 0.8372926957245633 21.213635053693494 -6.943353629011168 0.6275892276697355 1.0014385819634004 0.7979279494237564 0.9985709807329844 0.0026674335654594066 0.08626946815686215 0.04788886062766051 0.0026680088237885846 0.011191988280271592 1.1393217046569067e-07 6.943353629011168 -0.20351063253964397 APNTPDILEIEFKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APNTPDILEIEFKK 14 1 P00966 P00966 ASS1 Argininosuccinate synthase 0 8925600.0 1472500.0 3753500.0 3699600.0 False True 2016923.0428162566 3587657.9588353634 2825830.67565371 1.0 1.7787778128737468 1.4010602366404445 20.943724607233673 -10.126102424016109 4.539459714283289 0.9999417046000657 1.5899190243988068 0.7648325495968833 0.15420255486008624 107615709.36326616 9.12121113846265 71591.55765441319 0.052787636063160844 7.47993073011834e-11 10.126102424016109 0.5899773197987411 APNVVVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 APNVVVTR 8 0 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 11124700.0 1197700.0 5570400.0 4356600.0 False True 1570196.2985432972 4739318.033249135 3905820.823458103 1.0 3.0182965261387356 2.4874729529560167 20.582513498652613 -10.09221374017024 4.970226361039498 0.9999549777913516 2.752884739543465 0.9356472526300721 0.21670781637939016 0.00012951330158116075 2.365413100946918e-05 0.20983281194372166 0.06994214697258297 8.086977966150498e-11 10.09221374017024 1.7529297617521133 APNVVVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 APNVVVTR 8 0 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 12578900.0 2961500.0 1844000.0 7773400.0 False True 2867488.803543144 2580318.816332965 5737313.342998682 1.0 0.8998531443765904 2.000814557988686 21.45135642239899 -6.884674743570296 1.0533527585673184 0.9330743516317613 2.086195300324803 0.9772659199020045 0.07494848851035009 0.12357108918516052 0.24793003947554954 0.05455753112611277 0.13365283509738282 1.3041431255004304e-07 6.884674743570296 1.1531209486930414 up APNVVVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APNVVVTR 8 0 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 12202800.0 1197700.0 5378000.0 5627100.0 False True 1640522.0566254873 5140382.177332246 4298094.873762295 1.0 3.1333819356905708 2.619955554028556 20.645723560175504 -10.014303780012128 5.134666524951774 0.9999842045976894 2.8766687448650528 0.9468476479347631 0.2096054426275629 3.911004503842262e-05 7.507780722361307e-06 0.20295135242898743 0.06764986570921955 9.676008027376197e-11 10.014303780012128 1.8766845402673633 APNVVVTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APNVVVTR 8 0 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 4506530.0 2961500.0 861130.0 683900.0 False True 2462618.4666950367 856490.9217690781 826900.3280036752 1.0 0.34779684037638764 0.33578093366343464 21.231761697833267 APNYSCVMTGSWDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 APNYSCVMTGSWDK 14 0 P78406;E9PQ57;E9PPG9 P78406 RAE1 mRNA export factor 0 7835200.0 1716200.0 3275200.0 2843800.0 False True 2249954.819704443 2786552.926629609 2549550.855655823 1.0 1.2384928364897807 1.1331564675555286 21.101464600969695 -10.306998318525766 4.915820212703559 0.9999271570118551 1.1858246520225193 0.805803841165359 0.04300339254142569 3.43480225045246e-05 4.842259950945529e-06 0.0416541509294661 0.013879285261897386 4.9317571339814595e-11 10.306998318525766 0.18589749501066422 APNYSCVMTGSWDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APNYSCVMTGSWDK 14 0 P78406;E9PQ57;E9PPG9 P78406 RAE1 mRNA export factor 0 7160500.0 1716200.0 2051900.0 3392400.0 False True 2350725.518561131 1961240.2732740855 2591184.98867111 1.0 0.8343127505905293 1.1022915981518606 21.164674662492587 -6.739454914085372 1.6886357258700297 0.9013541288535073 1.102431558523565 0.6024987756204423 0.06961578068737277 0.31881259393471933 1.7847875274599194 0.03261626867136742 0.08008707516514157 1.821986211232898e-07 6.739454914085372 0.2010774296700576 APPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPSAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APPFHPPGPMPSVGSMPSAGPMPSAGPMPSAGPVPSAR 38 0 C9JFV4;Q8IZL8;E7EV54 C9JFV4 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 0 38617800.0 8078900.0 22472000.0 8066900.0 False True 10458295.308927223 21221413.445524413 6598806.973383821 1.0 2.0291465118038663 0.63096391701151 23.31814437719393 -6.709456040448625 1.7969738922554555 1.6330406988779658 0.6342762138136656 0.462592981802435 0.43371311986447236 0.37617113397710167 2.367475885883096 0.1920876156392262 0.48834603737992777 1.9522883358541908e-07 6.709456040448625 -0.9987644850643002 APPLK(ub)SSNQTAPSLNNIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 APPLKSSNQTAPSLNNIIK 19 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 13692500.0 4920100.0 3685300.0 5087100.0 True False 4763914.118626576 5156859.508585615 3754635.900271257 1.0 1.0824837266529743 0.7881409712217291 22.183715974602535 -6.831889002248231 1.319349863823462 1.0440204342504034 0.779904917660855 0.9096157948936221 0.03727143300093432 0.17849314190896312 0.6069629301139349 0.02217557370455695 0.05103392296767675 1.4726888467573165e-07 6.831889002248231 -0.26411551658954835 APPQPEK(ub)LQTNNVGK(ub)KK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 APPQPEKLQTNNVGKKK 17 3 Q05BV3;Q05BV3-5 Q05BV3 EML5 Echinoderm microtubule-associated protein-like 5 3 27018200.0 4944200.0 11171000.0 10903000.0 True False 6481894.079700901 9504330.344216952 9774862.148961036 1.0 1.4662890549201195 1.5080255907872047 22.62798401516679 -11.74501863079296 0.3910521330639252 8.337019697187015e-10 1.511444322360019 0.9996798761596651 0.004120156130725009 4.678286891831369 0.1987639679329918 3.8932773828746567 0.010942099122438322 1.798793747045563e-12 11.74501863079296 1.511444321526317 APPQPEK(ub)LQTNNVGK(ub)KK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 APPQPEKLQTNNVGKKK 17 3 Q05BV3;Q05BV3-5 Q05BV3 EML5 Echinoderm microtubule-associated protein-like 5 3 49070000.0 13221000.0 13569000.0 22280000.0 True False 12801306.591809517 18987172.4614002 16444199.614327142 1.0 1.483221445031908 1.2845719689932593 23.609787733602584 -10.154436197337088 4.589444831576933 0.9999587344721144 1.3838967069132933 0.8327641560557684 0.08109830919095207 4.193397931064931e-05 7.726038757302697e-06 0.0785334126157819 0.02617436671242474 7.007511233943704e-11 10.154436197337088 0.3839379724411789 APPQPEK(ub)LQTNNVGK(ub)KK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 APPQPEKLQTNNVGKKK 17 3 Q05BV3;Q05BV3-5 Q05BV3 EML5 Echinoderm microtubule-associated protein-like 5 3 54271000.0 14045000.0 21875000.0 18351000.0 True False 21307291.82703801 17971235.339844905 14723916.806470964 1.0 0.8434312293522072 0.6910271340906387 24.344843901349645 -6.971455812095343 0.22067172586778355 1.069688615226264 0.460462964317732 0.9999916156850914 0.00036520557182309046 0.07583316316530582 0.0073166735113876355 0.004199851757638422 0.015425019919371601 1.0679334454062664e-07 6.971455812095343 -0.6092256509085319 APPQPEK(ub)LQTNNVGK(ub)KK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APPQPEKLQTNNVGKKK 17 3 Q05BV3;Q05BV3-5 Q05BV3 EML5 Echinoderm microtubule-associated protein-like 5 3 26749900.0 4944200.0 7962700.0 13843000.0 True False 6772204.3519810755 7610881.584872336 10573568.505534172 1.0 1.123841099485712 1.5613185834300882 22.69119407668968 -6.947732412743028 0.5832167468843944 0.9948312312494689 1.7120863236330055 0.9990110313778706 0.007572209624271279 0.0844094547012399 0.03983223406578375 0.00790636092888693 0.036577499550035676 1.1278921843578726e-07 6.947732412743028 0.7172550923835366 APPQPEK(ub)LQTNNVGK(ub)KK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APPQPEKLQTNNVGKKK 17 3 Q05BV3;Q05BV3-5 Q05BV3 EML5 Echinoderm microtubule-associated protein-like 5 3 42747000.0 13221000.0 16737000.0 12789000.0 True False 10993847.289608328 16646834.458965609 15463120.770345103 1.0 1.5141955332325412 1.4065249737424723 23.39019300903686 -10.054884930352031 4.665967901483469 0.9999853739849178 1.4603602534453306 0.960590767286726 0.04395632193465529 30460724.994226802 0.22857034277217705 5862.942971670074 0.015047418154024928 8.812823445809628e-11 10.054884930352031 0.4603748794604128 APPQPEK(ub)LQTNNVGK(ub)KK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APPQPEKLQTNNVGKKK 17 3 Q05BV3;Q05BV3-5 Q05BV3 EML5 Echinoderm microtubule-associated protein-like 5 3 37492000.0 14045000.0 13247000.0 10200000.0 True False 18181529.368340097 12509792.804951131 8343704.660838098 1.0 0.688049533761154 0.45891104602933885 24.115970223442094 -7.667300667406241 0.15653933169265521 1.3006239023951465 3.093069064065468e-14 0.9999710918518983 0.0011923038353509178 0.13490597147322853 0.01814084631920552 0.053567812941772354 0.08333598401965459 2.1512918532681146e-08 7.667300667406241 -1.3006239023951156 down APPSVFAEVPQAQPVLVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 APPSVFAEVPQAQPVLVFK 19 0 P17174 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 4366420.0 535720.0 2266300.0 1564400.0 False True 702334.1079198596 1928176.873968209 1402530.894784431 1.0 2.745384073228329 1.9969568314692583 19.42179797387099 -10.61912707626826 6.123729937617885 0.9936213537307262 2.371170452348793 0.8173617093210677 0.30554414198472485 0.02651697068295104 0.0016492531853224488 0.29482424007562774 0.09861394778650609 2.4036593769414128e-11 10.61912707626826 1.3775490986180667 APPSVFAEVPQAQPVLVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 APPSVFAEVPQAQPVLVFK 19 0 P17174 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 5958100.0 2219500.0 1130900.0 2607700.0 False True 2149043.187392877 1582474.267565591 1924665.1406768789 1.0 0.7363622456956661 0.8955916530517921 21.035263044929085 -10.294894624423309 5.407376319052643 1.000028320506362 0.8159769496159321 0.6404026446206447 0.06500513334474178 2.2197499449554686e-05 2.8945067271398845e-06 0.06295062773957945 0.02098031657184387 5.0711373751491896e-11 10.294894624423309 -0.1840513708904299 APPSVFAEVPQAQPVLVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APPSVFAEVPQAQPVLVFK 19 0 P17174 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 6531820.0 535720.0 2490100.0 3506000.0 False True 733790.1612886422 2380079.1483404627 2677955.00833655 1.0 3.2435419196145907 3.6494833940450655 19.485008035393882 -9.970831310677799 0.4140864662557583 1.7621531986793718e-21 3.6842005710318757 0.9988996313704692 0.038649907023821595 1.2930220301265798 0.18513623403143217 1.7134520376775408 0.099232725978003 1.0694702037976432e-10 9.970831310677799 3.6842005710318757 APPVDDAEVDELVLQTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 APPVDDAEVDELVLQTKR 18 1 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 8861300.0 3183500.0 3467300.0 2210500.0 True False 3082441.5350597952 4851810.971730639 1631503.7364214633 1.0 1.5740155706267176 0.5292894343216843 21.555642100487827 -6.75753080730889 1.6217661010232756 1.3344404322136736 0.5259312700612659 0.6808141465074549 0.24135440877699824 0.28708168766569625 1.4875693171056492 0.11745453766466875 0.28295411222586875 1.7477092817284586e-07 6.75753080730889 -0.8085091621524076 APPVDDAEVDELVLQTK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APPVDDAEVDELVLQTKR 18 1 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 1 6657100.0 1108500.0 2591500.0 2957100.0 True False 1518342.4060861287 2476998.9610555037 2258693.8833862003 1.0 1.631383639900126 1.487605084553026 20.53406574338316 -10.075083781801206 4.6802250318358345 0.9999756632623737 1.559494362167276 0.9528085091814454 0.058697349480461083 7234118.860963464 15572831.769872326 1175.4267112730797 0.020093664787028575 8.412328397872606e-11 10.075083781801206 0.5595186989049024 APQCLGK(ub)FIEIAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 APQCLGKFIEIAAR 14 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4;A0A1W2PPE9 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 20535600.0 5721100.0 9668300.0 5146200.0 True False 7500417.503211203 8225827.326738231 4613720.589836128 1.0 1.096715925908985 0.6151285028947823 22.838539473339093 -6.854463605265647 1.2133350360075468 1.0518811015011684 0.5941505810699681 0.9465561665884207 0.048087160520791365 0.15261347884375065 0.430109483858822 0.030972674990939187 0.07190898042490101 1.3980940734551628e-07 6.854463605265647 -0.4577305204312003 APQCLGK(ub)FIEIAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 APQCLGKFIEIAAR 14 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4;A0A1W2PPE9 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 21220500.0 7483200.0 7587600.0 6149700.0 True False 7245649.912096581 10617368.248811292 4538909.082954563 1.0 1.4653438100957157 0.6264322922056824 22.78868367013557 -6.756155714540776 1.6271232967411662 1.2715871697345515 0.6239551310252184 0.6750148910708359 0.19563061608224855 0.2894203952547904 1.5093003782059475 0.09490888137019811 0.22893861470485674 1.7532517677595822e-07 6.756155714540776 -0.6476320387093332 APQCLGK(ub)FIEIAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APQCLGKFIEIAAR 14 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4;A0A1W2PPE9 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 18380500.0 5721100.0 6810400.0 5849000.0 True False 7836345.276914149 6509494.009018878 4467586.6639362415 1.0 0.8306798359428891 0.5701110027780092 22.901749534861985 -6.964828063877398 0.3609904702971812 1.0222006835850637 0.36964699784096816 0.9999095568819244 0.0016815230786669357 0.07801934800656989 0.0150659304693032 0.0034889931595483204 0.022242747175525684 1.0843561229897169e-07 6.964828063877398 -0.6525536857440954 APQCLGK(ub)FIEIAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APQCLGKFIEIAAR 14 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4;A0A1W2PPE9 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 18279000.0 7483200.0 4575700.0 6220100.0 True False 6222612.361969365 4551049.795894656 7520694.15150703 1.0 0.7313728593651809 1.2086072077173133 22.569088945569845 -6.753984782168482 1.6352012742972948 0.8428053067558677 1.2098462486367456 0.6659175939794899 0.11290800792358753 0.2931341683725868 1.543297086785879 0.05451982099671403 0.13180505033935905 1.7620377877542258e-07 6.753984782168482 0.3670409418808779 APQCLGK(ub)FIEIAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APQCLGKFIEIAAR 14 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4;A0A1W2PPE9 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 33771100.0 6769100.0 12730000.0 14272000.0 True False 8762733.388909291 12021564.30943064 11674642.44308642 1.0 1.3718966189985817 1.3323060197018703 23.062949534072313 -10.08109794230867 4.4377734310081385 0.999971774490083 1.3521013193738758 0.9906068448540017 0.016162794579873043 11229646.202978848 0.0859399880520774 3377.0222324052497 0.0055329544750179985 8.296636402557858e-11 10.08109794230867 0.3521295448837928 APQHK(ub)GHTTALVEDVCQGYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 APQHKGHTTALVEDVCQGYK 20 1 O00635 O00635 TRIM38 E3 ubiquitin-protein ligase TRIM38 1 138188000.0 17341000.0 48224000.0 72623000.0 True False 26307564.796914652 39618050.42416825 58269032.21820828 1.0 1.5059565843515341 2.2149154689164567 24.648974373452134 -6.966364492324316 0.33380555600815 0.9173705393200894 2.8268429874690675 0.999938572318646 0.0039053824331396216 0.07750093375579162 0.013243695182972196 0.01020922629105811 0.06165096859745766 1.0805267120238572e-07 6.966364492324316 1.909472448148978 APQHK(ub)GHTTALVEDVCQGYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APQHKGHTTALVEDVCQGYK 20 1 O00635 O00635 TRIM38 E3 ubiquitin-protein ligase TRIM38 1 96526000.0 17341000.0 43412000.0 35773000.0 True False 22448266.342213295 40996084.03778502 29262681.06197666 1.0 1.8262472216258905 1.3035608458969974 24.420100695544583 -10.10310203423521 4.251120004213823 0.9999199588004484 1.5649040330304744 0.6089809143341443 0.21338581964159037 27453776.548788182 16311498.146856438 20431.668347144176 0.07304764103477163 7.886748026133336e-11 10.10310203423521 0.5649840742300261 APQLVGQFIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 APQLVGQFIAR 11 0 Q53EL6;Q53EL6-2 Q53EL6 PDCD4 Programmed cell death protein 4 0 19874600.0 5720200.0 5031200.0 9123200.0 False True 7499237.594495603 4280564.571464002 8179218.7799139125 1.0 0.5707999670001004 1.0906733753731728 22.838312501659395 -6.687430153071114 1.8754476044057289 0.7302701051171835 1.0888263040574042 0.3584093535996652 0.18161795001247447 0.42224944642279116 2.877424675661172 0.07752705749071476 0.20254968388696853 2.053855318360668e-07 6.687430153071114 0.3585561989402207 APQLVGQFIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 APQLVGQFIAR 11 0 Q53EL6;Q53EL6-2 Q53EL6 PDCD4 Programmed cell death protein 4 0 14926200.0 5548600.0 1753500.0 7624100.0 False True 5372462.730150081 2453681.6943816976 5627119.491902682 1.0 0.456714512063847 1.04740037754445 22.357152138747516 -6.6649184166381685 1.9558994043226339 0.6517175286967489 1.0449440772241552 0.25662450112604107 0.23104960084020784 0.47282506708611405 3.4822832101113073 0.09528085021453929 0.25621767147057833 2.1631248342577415e-07 6.6649184166381685 0.39322654852740624 APQLVGQFIAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 APQLVGQFIAR 11 0 Q53EL6;Q53EL6-2 Q53EL6 PDCD4 Programmed cell death protein 4 0 20068600.0 2222700.0 11627000.0 6218900.0 False True 3371998.4011361636 9552071.007834366 4989731.689159304 1.0 2.8327626147793796 1.479755057854731 21.685172421537303 -6.568375696830144 2.3130621571459304 2.256684878507062 1.4824570658486638 0.0 0.798548399547471 0.7350223897132242 7.380275174540975 0.29206392891249966 0.8955863092464457 2.7016202517115716e-07 6.568375696830144 -0.7742278126583984 APQLVGQFIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APQLVGQFIAR 11 0 Q53EL6;Q53EL6-2 Q53EL6 PDCD4 Programmed cell death protein 4 0 16286500.0 5720200.0 5102600.0 5463700.0 False True 7835112.522592575 4877150.259958256 4173286.5884336596 1.0 0.6224735440486624 0.5326390114245293 22.901522563182287 -13.999999999999998 0.2016749013788423 3.112119779146439 0.47524981675509237 0.9994870777804885 0.004585964992424407 12.564498254899014 0.14238916933758156 10.475562886360708 0.056495608269565935 1.0000000000000041e-14 13.999999999999998 -2.6368699623913465 APQLVGQFIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APQLVGQFIAR 11 0 Q53EL6;Q53EL6-2 Q53EL6 PDCD4 Programmed cell death protein 4 0 11289700.0 5548600.0 2519000.0 3222100.0 False True 4613906.744657796 2505429.647017646 3895826.2126928535 1.0 0.5430169671111262 0.8443660499214964 22.137557414181792 -10.101933506723205 5.338082472308074 1.0000049227285444 0.6936915085160971 0.5794043982033089 0.12302524789093976 171305195.76774973 0.10551063277751789 10365.21214262099 0.04211481463271746 7.907996952480519e-11 10.101933506723205 -0.3063134142124473 APQLVGQFIAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APQLVGQFIAR 11 0 Q53EL6;Q53EL6-2 Q53EL6 PDCD4 Programmed cell death protein 4 0 17451900.0 2222700.0 9248800.0 5980400.0 False True 2877328.965967217 8734096.149651395 4892028.564085899 1.0 3.035487513926104 1.7001978647378746 21.456298743629752 -10.034102477316416 4.855272777436204 0.9999757175291862 2.3678426893536666 0.5831833618173028 0.5451297166335679 188490809.18289906 0.47322735586959114 58892.438173786264 0.1866124015922531 9.244800053632029e-11 10.034102477316416 1.3678669718244802 APSPEK(ub)AEEESER ddPTM_RPMI8226_Bortezomib_1h_R1 1 APSPEKAEEESER 13 1 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 4485800.0 1437900.0 1398700.0 1649200.0 True False 1885100.8246434072 1190019.4120898969 1478556.6042434715 1.0 0.6312762673131849 0.7843382088187039 20.846210257445716 -10.133607046826683 5.203599111962516 1.0000090637485235 0.7078072392080257 0.8293212057979692 0.06248727595565019 6.570819656727668e-06 1.0940194264854797e-06 0.06050492115183586 0.020167681593706077 7.351787630244097e-11 10.133607046826683 -0.2922018245404978 APSPEK(ub)AEEESER ddPTM_RPMI8226_Bortezomib_2h_R1 1 APSPEKAEEESER 13 1 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 6930500.0 1581500.0 1474300.0 3874700.0 True False 1531296.1481693313 2062995.6783729314 2859799.8314916277 1.0 1.347221881828181 1.8675680957667962 20.546321892121384 -6.965273080597098 0.35334001930071146 0.9516083669642995 2.2808302364700963 0.9999186577743668 0.0032155008668411466 0.0778684793502466 0.014534272406805208 0.007084194643938852 0.044627855197420636 1.0832455644305565e-07 6.965273080597098 1.3292218695057967 APSPEK(ub)AEEESER ddPTM_RPMI8226_Bortezomib_8h_R1 1 APSPEKAEEESER 13 1 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 22050900.0 3032700.0 4899200.0 14119000.0 True False 4600827.620068216 4024899.48237569 11328373.461422468 1.0 0.8748207528618542 2.462246881845685 22.133461973096008 -6.887834545501563 1.035143493277101 0.9102249207594351 2.5931075615720522 0.9794743535487838 0.10324291409549145 0.12091621094995214 0.23226969254844468 0.0762046200032405 0.18855079227895663 1.294688989134131e-07 6.887834545501563 1.6828826408126172 up APSPEK(ub)AEEESER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APSPEKAEEESER 13 1 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 4661660.0 1437900.0 927260.0 2296500.0 True False 1969530.4877864155 886290.5871612305 1754113.997902133 1.0 0.4500009482754165 0.8906254606262063 20.909420318968607 -9.97503709144275 6.9447580229067025 1.000000025117833 0.6703132044508155 0.4274120373616185 0.1798842039036858 6.999009848434277e-08 1.0464048838871066e-08 0.1741721444679944 0.05805737716372917 1.0591632622015481e-10 9.97503709144275 -0.3296868206670174 APSPEK(ub)AEEESER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APSPEKAEEESER 13 1 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 7310400.0 1581500.0 2776500.0 2952400.0 True False 1315087.3223292907 2761542.443407899 3569733.1896447586 1.0 2.0998928333645845 2.7144457474671913 20.32672716755566 -9.00997602696974 0.1914151202347195 1.1010328536322485e-15 3.4158011919640767 0.9996279812142191 0.013679022276426407 0.48244303586359905 0.06376077649651259 0.6470207846271885 0.3514019148635605 9.772911658827e-10 9.00997602696974 3.415801191964076 APSPEK(ub)AEEESER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APSPEKAEEESER 13 1 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 21148500.0 3032700.0 3215800.0 14900000.0 True False 3925889.9334542505 3036837.9030846087 12188352.886910578 1.0 0.7735412746053743 3.1046089150508815 21.904588295188457 -6.8830503611596665 1.0626916982851689 0.8530974112177261 3.2797514796122273 0.9760617150225059 0.16239083504180274 0.1249601122161504 0.2562763313670995 0.11737620753586685 0.28616599572217777 1.3090301179454846e-07 6.8830503611596665 2.4266540683945013 up APSYLEISSMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 APSYLEISSMR 11 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 0 16105800.0 2680000.0 4811200.0 8614600.0 False True 3513505.9531569155 4093387.7139107124 7723243.829078221 1.0 1.1650436255082386 2.19815874287585 21.744479912338093 -6.934945303085204 0.7050215658756375 0.9867954731843444 2.439687848271873 0.9974240041722368 0.026910669371608107 0.09015004779080892 0.06568928077463546 0.025283152824854556 0.0910717354045535 1.1615949008855611e-07 6.934945303085204 1.4528923750875284 up APSYLEISSMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APSYLEISSMR 11 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 0 11586400.0 2680000.0 3708400.0 5198000.0 False True 3670868.424276787 3544550.625961113 3970339.4561703918 1.0 0.9655891239576203 1.0815804320070679 21.807689973860985 -6.827207173401123 1.3401916962204534 0.9815743420326007 1.0845306913544739 0.9002061321044666 0.015365749598119169 0.18427884805602782 0.648273235112441 0.009004298862367905 0.020726929841995787 1.4886507706989347e-07 6.827207173401123 0.10295634932187314 APTIVGK(ub)SSLNPILFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 APTIVGKSSLNPILFR 16 1 A0A0C4DGS1;P39656;P39656-3;P39656-2;U3KQ84 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 1 44761000.0 9246800.0 16014200.0 19500000.0 True False 8953265.39544243 22408753.57294974 14392365.012539474 1.0 2.5028581844962052 1.6074989824233026 23.093982521044623 -9.951491091778916 5.844845259153301 0.9999992148483224 2.0551785834602305 0.6493453169719181 0.3655288635990418 3.7399003627909346e-06 6.704152304673129e-07 0.35392206397026954 0.1179739334395207 1.1181727602382862e-10 9.951491091778916 1.055179368611908 APTIVGK(ub)SSLNPILFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 APTIVGKSSLNPILFR 16 1 A0A0C4DGS1;P39656;P39656-3;P39656-2;U3KQ84 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 1 121479200.0 7186500.0 29340400.0 84952300.0 True False 10902445.903525 24104376.38240845 68161440.66908419 1.0 2.2109145595131983 6.251940277644129 23.37814849618943 -6.949034846671021 0.5693402754846746 0.9495108086233244 7.709593500048292 0.9991233552049664 0.06648419498011002 0.08387561696210054 0.03758415495654427 0.07048904692479627 0.3366425716920029 1.1245147421794433e-07 6.949034846671021 6.760082691424968 APTIVGK(ub)SSLNPILFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APTIVGKSSLNPILFR 16 1 A0A0C4DGS1;P39656;P39656-3;P39656-2;U3KQ84 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 1 40643800.0 9246800.0 13934000.0 17463000.0 True False 7689123.902696497 13858934.776317565 21114432.560210824 1.0 1.802407524146851 2.746012787335396 22.8743877964789 -6.9689858638909135 0.2813545550454903 0.7954804546446571 3.78174693267815 0.9999733568524921 0.003683298134797243 0.07663313968091563 0.010202730934064593 0.017294624628101645 0.08646401192370437 1.0740243708295757e-07 6.9689858638909135 2.986266478033493 APTIVGK(ub)SSLNPILFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APTIVGKSSLNPILFR 16 1 A0A0C4DGS1;P39656;P39656-3;P39656-2;U3KQ84 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 1 147870500.0 7186500.0 30539000.0 110145000.0 True False 9303065.917093348 28839477.804061465 90099740.18313852 1.0 3.099997147292285 9.684951282306866 23.149274818281878 -6.950452003214854 0.5538587953706531 0.9109464624339791 12.185408263593127 0.999236281370647 0.10224704586046114 0.08330474047811978 0.03521508468608167 0.11043433068694887 0.5466873663200109 1.1208512920576984e-07 6.950452003214854 11.274461801159148 APTYFCGQTLTFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 APTYFCGQTLTFR 13 0 Q8IUI8-2;Q8IUI8 Q8IUI8-2 CRLF3 Cytokine receptor-like factor 3 0 7568900.0 1767300.0 2380100.0 3421500.0 False True 2316947.414557547 2024998.3575571342 3067476.001345518 1.0 0.8739940944856687 1.3239299183366642 21.14379387048938 -6.831966263596394 1.3192771365446438 0.9327596866867576 1.3365155923770824 0.9097175259930668 0.056944260138106335 0.1783989603641722 0.6065906517438606 0.0338845328910016 0.07796924124143792 1.4724268774942558e-07 6.831966263596394 0.4037559056903248 APTYFCGQTLTFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APTYFCGQTLTFR 13 0 Q8IUI8-2;Q8IUI8 Q8IUI8-2 CRLF3 Cytokine receptor-like factor 3 0 6396700.0 1767300.0 2385200.0 2244200.0 False True 2420718.5694867065 2279813.9771983735 1714166.1807498236 1.0 0.9417922454661012 0.708122869943241 21.20700393201227 -6.944792364725977 0.613363497200067 1.0025733235151584 0.6351026398451323 0.9987265810420771 0.004500988680637947 0.08564681775901568 0.04515400391748444 0.0045606986689855755 0.019727187510139015 1.135553591684414e-07 6.944792364725977 -0.3674706836700261 APVAGTCYQAEWDDYVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 APVAGTCYQAEWDDYVPK 18 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 48290500.0 8373500.0 22770000.0 17147000.0 False True 10977739.589089345 19372804.75676482 15372792.925638353 1.0 1.7647353172796374 1.4003605023494274 23.38807768582872 -10.192699298521164 4.641402709279237 0.9998956961170338 1.5825479098190942 0.7731420654408558 0.14875539529916204 0.00016059234115241728 2.7932721482409965e-05 0.144057397527197 0.04801059738544517 6.416536978950598e-11 10.192699298521164 0.5826522137020604 APVAGTCYQAEWDDYVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 APVAGTCYQAEWDDYVPK 18 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 25767900.0 12313000.0 2517900.0 10937000.0 False True 11922130.554795437 3523310.600675038 8072271.597033032 1.0 0.29552692654064733 0.6770829727062604 23.507138741133556 -10.717735346143314 6.893010479518166 1.0058217313976747 0.4863049496245793 0.7073247318816542 0.15576960356326233 0.013974764646835227 0.0005722576105045575 0.15124017363686273 0.050274423370487216 1.9154228051642596e-11 10.717735346143314 -0.5195167817730955 APVAGTCYQAEWDDYVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APVAGTCYQAEWDDYVPK 18 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 44026500.0 8373500.0 16949000.0 18704000.0 False True 11469409.235328987 16200137.137152124 14286500.42097172 1.0 1.4124648275040332 1.2456178106336377 23.45128774735161 -10.158526518991195 5.228748432807394 0.9999868961989071 1.3290413190690344 0.8383353510074498 0.06811500940702901 1.0405400536744318e-05 1.6745186212540295e-06 0.06595469863235698 0.021984024754915343 6.941822121033901e-11 10.158526518991195 0.3290544228701273 APVAGTCYQAEWDDYVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APVAGTCYQAEWDDYVPK 18 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 21181100.0 12313000.0 3245600.0 5622500.0 False True 10238805.058387961 3228115.308598839 6798138.754497248 1.0 0.31528242702054987 0.6639582173632647 23.287544016567832 -10.6342267206763 6.693198561520652 1.0018184450683116 0.48962032219243423 0.7407186033187186 0.14234629533354962 0.003873333057094538 0.00021167183040038352 0.13820849318603487 0.045942069268430016 2.3215245428152162e-11 10.6342267206763 -0.5121981228758774 APVAGTCYQAEWDDYVPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 APVAGTCYQAEWDDYVPK 18 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 11611700.0 2937200.0 8674500.0 0.0 False True 3802263.3008678164 8191756.449501657 0.0 1.0 2.1544421838519168 0.0 21.85842700917584 -6.765213760083601 1.6192587730676729 1.669428414534942 9.353233289144294e-10 0.695462183255382 0.4857932483846234 0.27798128361999985 1.4419759364631723 0.23764123856812744 0.5622290875300401 1.7170630393635549e-07 6.765213760083601 -1.6694284135996187 APVGGLGK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 1 APVGGLGKLK 10 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG63;S4R306 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 6448350.0 941850.0 1311200.0 4195300.0 True False 911951.4872926256 1834768.9978176677 3096425.073697787 1.0 2.0119151329690523 3.395383544897066 19.798597554414652 -6.966752194214564 0.3265857775512263 0.8245965925991559 4.62776191133293 0.9999448407071716 0.007291942001623827 0.07737130952415452 0.012789866790779085 0.020439937107272637 0.12100711334934658 1.0795625383298023e-07 6.966752194214564 3.8031653187337735 APVPASELLASGVLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 APVPASELLASGVLSR 16 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 5130690.0 707490.0 2455000.0 1968200.0 False True 927526.2413429053 2088723.5695150467 1764549.5443075416 1.0 2.2519293540319882 1.9024254685805593 19.82302857311875 -10.191566539873023 4.909163619593919 0.9998842409096323 2.077177411308491 0.926820968704045 0.14268436375368845 0.00018079500602843598 2.9773347817031654e-05 0.13816814474964323 0.04605118038075955 6.433294905367641e-11 10.191566539873023 1.0772931703988586 APVPTGEVYFADSFDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 APVPTGEVYFADSFDR 16 0 P27824;P27824-2;H0Y9Q7;D6RAQ8;D6RAU8;D6RB85;D6RDP7;D6RHJ3;D6RD16 P27824 CANX Calnexin 0 4959880.0 973880.0 1828400.0 2157600.0 False True 1276766.111067336 1555609.8470473778 1934352.2491606285 1.0 1.218398447110205 1.5150404074741388 20.284062833356135 -6.966854221456623 0.32465827860220575 0.9615329140159958 1.781540024496441 0.9999464221786953 0.001544967257820636 0.07733726315099124 0.012670732457573173 0.004414751059535714 0.02598826074584057 1.0793089503703442e-07 6.966854221456623 0.8200071104804452 APVPTGEVYFADSFDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APVPTGEVYFADSFDR 16 0 P27824;P27824-2;H0Y9Q7;D6RAQ8;D6RAU8;D6RB85;D6RDP7;D6RHJ3;D6RD16 P27824 CANX Calnexin 0 5476780.0 973880.0 1722100.0 2780800.0 False True 1333949.754117418 1646011.9277768426 2124032.3123737224 1.0 1.2339384768400774 1.5922880946734363 20.347272894879026 -6.964906271423816 0.359660214232575 0.9690009052017967 1.8694993485523408 0.9999111962888448 0.002295313136900032 0.07799280900851527 0.01497238400614207 0.004811120188772212 0.030613795633123827 1.0841608702291901e-07 6.964906271423816 0.9004984433505441 APVQPQQSPAAAPGGTDEK(ub)PSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 APVQPQQSPAAAPGGTDEKPSGK 23 1 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 11789000.0 4315400.0 5596600.0 1877000.0 True False 5657531.190393043 4761609.095375936 1682786.0454553678 1.0 0.8416408032290733 0.2974417619319321 22.431741202524044 -6.948363891574651 0.5765251274355431 1.006593287916232 0.10573247852919218 0.9990665616423905 0.00919288592680538 0.08414943635190934 0.038733045903407995 0.009668343198815068 0.0454177717993901 1.1262533827870801e-07 6.948363891574651 -0.9008608093870398 down APVQPQQSPAAAPGGTDEK(ub)PSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 APVQPQQSPAAAPGGTDEKPSGK 23 1 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 38359000.0 19171000.0 13529000.0 5659000.0 True False 29083808.587835222 11114644.247440524 4540496.169572192 1.0 0.3821591733377521 0.15611766099544916 24.793712869885827 -10.626468371664222 0.2147249465907525 1.8307211032238666 2.415486539756929e-16 0.9993015879842787 0.00942604630637619 2.416315369383743 0.11166013008706084 1.1751156008076435 0.1249047735830297 2.363369509843235e-11 10.626468371664222 -1.8307211032238664 APVQPQQSPAAAPGGTDEK(ub)PSGK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APVQPQQSPAAAPGGTDEKPSGKER 25 2 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 2 7671800.0 1600700.0 5009500.0 1061600.0 True False 1331052.9730335118 4982512.829192102 1283575.6517161878 1.0 3.743286653600869 0.9643310053925791 20.344136557863216 -6.649092069190704 2.0114086538942333 2.7813398957627795 0.9759142314716901 0.19055820616036956 1.1711140600338354 0.5107307734485944 3.959457003883929 0.47232567619237453 1.2973992500732487 2.2434062776384683e-07 6.649092069190704 -1.8054256642910893 APVQPQQSPAAAPGGTDEKPSGK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 APVQPQQSPAAAPGGTDEKPSGKER 25 2 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 39171900.0 26551100.0 1111800.0 11509000.0 True False 34808749.22121816 945923.7737624559 10318159.082123509 1.0 0.027174885479247693 0.29642429886087174 25.052946639009537 -10.291415097907931 5.061610099187482 1.000217153768854 0.16179959216981615 0.928170503330023 0.10992061272230921 0.0002694304364371128 3.77180269766175e-05 0.10645705335934877 0.03547672520641118 5.111930045839179e-11 10.291415097907931 -0.8384175615990379 APVQPQQSPAAAPGGTDEKPSGK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 APVQPQQSPAAAPGGTDEKPSGKER 25 2 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 121701400.0 101946800.0 3205600.0 16549000.0 True False 154660748.9094112 2633535.6345328824 13278082.896315642 1.0 0.017027821558496477 0.08585295874968871 27.20453186319797 -10.67802118737368 2.9387811796268 1.107355681152621 0.05144038829860528 0.9960670813212864 0.028097750472708082 17872500.75972896 17414323.89489773 14369789.932657754 0.010836647406137047 2.0988374878051524e-11 10.67802118737368 -1.0559152928540159 APVQPQQSPAAAPGGTDEKPSGK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 APVQPQQSPAAAPGGTDEKPSGKER 25 2 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 61436900.0 1037800.0 51903300.0 8495800.0 True False 862976.6823353397 51623686.62090163 10272232.49985909 1.0 59.82048840670928 11.903256148313236 19.718962052689655 -10.043188630831315 6.101530075371405 0.9999494342981556 35.86187227751262 0.4137508660851472 19.562128153254918 0.01347051035425083 0.0021123119852238885 18.94096641818993 6.313649712826918 9.05339291743301e-11 10.043188630831315 34.86192284321446 APWELLELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 APWELLELR 9 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 3409450.0 724310.0 1702600.0 982540.0 False True 949577.4242280187 1448578.716682821 880876.1859891947 1.0 1.5254982687277734 0.9276507249583399 19.856926110405 -6.674584796001087 1.9213575193733252 1.3340932646503716 0.9300239079726854 0.29945768062424427 0.22298719682337734 0.45064521243437977 3.2115630248478335 0.09329429562038034 0.24775689197778827 2.1155105914539693e-07 6.674584796001087 -0.4040693566776862 APWELLELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 APWELLELR 9 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 4524210.0 724310.0 1529600.0 2270300.0 False True 992106.9807417627 1462017.214289216 1734101.898296197 1.0 1.4736487522707666 1.7478980915945894 19.92013617192789 -9.819812830478597 0.11613149113931766 7.073534116200881e-09 2.3725386738401504 0.9998912626733745 0.003221369517230609 1.3626662802486176 0.051735706897677945 0.7425699859554169 0.3287826500206994 1.5142136941864654e-10 9.819812830478597 2.372538666766616 AQAAAPASVPAQAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQAAAPASVPAQAPK 15 0 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 0 28020700.0 6772700.0 2551000.0 18697000.0 False True 6557704.345688548 3569627.603289255 13799694.802023089 1.0 0.5443410399610582 2.104348423560127 22.644759428569014 -6.828520148001381 1.334471743984499 0.7562648126958599 2.1450840471983796 0.9028918281750445 0.20410195953720942 0.18264245835321616 0.6366229959714638 0.12010415020780266 0.27642016867830294 1.484157024730984e-07 6.828520148001381 1.3888192345025199 up AQAAAPASVPAQAPK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQAAAPASVPAQAPKR 16 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 2531530.0 749430.0 867420.0 914680.0 True False 982509.9874904443 738004.317176677 820037.6878301107 1.0 0.7511417965955839 0.8346354726883488 19.906112547283577 -10.593111711200043 9.093785052559884 1.0000413094386054 0.7928886346419664 0.8913546568979511 0.03408615052941479 2.8553579347192537e-05 1.2775605256565572e-06 0.03301033138637807 0.01100125777806188 2.5520447696746737e-11 10.593111711200043 -0.207152674796639 AQAAAPASVPAQAPK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQAAAPASVPAQAPKR 16 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 5487600.0 1714400.0 2058600.0 1714600.0 True False 1659977.310415116 2880609.7154571824 1265494.823102572 1.0 1.735330776742255 0.7623566991925363 20.662732091393178 -6.704573372871244 1.8146552518964496 1.4545508915685856 0.7649976564784944 0.43927495175637343 0.3101403541148933 0.38607722558679725 2.4747307741445534 0.1361899981708705 0.34826869778280267 1.9743612882619528e-07 6.704573372871244 -0.6895532350900913 AQAAAPASVPAQAPK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQAAAPASVPAQAPKR 16 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 5589770.0 1714400.0 3103800.0 771570.0 True False 1425599.5607975589 3087079.2133439365 932901.7196633944 1.0 2.1654602724602796 0.6543925414381285 20.443137366827454 -6.700733526578654 1.8282078614050143 1.7231970921125077 0.6588303389924018 0.421009493082508 0.4918923302241065 0.3940391723676326 2.560963024147712 0.21460382487026458 0.5514146141947177 1.9918951466096965e-07 6.700733526578654 -1.064366753120106 AQAALAVNISAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQAALAVNISAAR 13 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 28549700.0 12607000.0 11795000.0 4147700.0 False True 16527899.08636167 10035231.976549905 3718535.791547803 1.0 0.6071692429941491 0.224985388168072 23.97840001495684 -7.619254899009701 0.3369403824928784 1.0713588498209514 4.4246511350920865e-20 0.9993140431309061 0.008286978739730291 0.1242294302248749 0.04437492145231284 0.026960755741928792 0.07268365121215327 2.4029520294293316e-08 7.619254899009701 -1.0713588498209514 down AQAALAVNISAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQAALAVNISAAR 13 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 37966100.0 15350000.0 12750000.0 9866100.0 False True 14862722.652165191 17841141.490371652 7281872.43334439 1.0 1.2003952376634417 0.48994202500869327 23.825195086748895 -6.831369502339395 1.3217403272068304 1.1069801360832534 0.47027808802217397 0.9085966674486976 0.09042201817606756 0.1791242430791235 0.6115178738275361 0.05370572294796094 0.12359179300368592 1.4744515205113692e-07 6.831369502339395 -0.6367020480610794 down AQAALAVNISAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQAALAVNISAAR 13 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 211429800.0 74412800.0 91114000.0 45903000.0 False True 112889657.90437983 74853994.82306883 36830251.9300004 1.0 0.6630722088508046 0.32625000920098884 26.750338082468502 -7.318998005433627 0.276152721127657 1.0958397216715345 3.451992568542458e-11 0.9998986544253997 0.002769010480989426 0.10761024204332371 0.019436123131430054 0.015227349818087437 0.049874067006410214 4.797356518937914e-08 7.318998005433627 -1.0958397216370146 down AQAALAVNISAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQAALAVNISAAR 13 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 28182100.0 12607000.0 9293600.0 6281500.0 False True 17268148.591364738 8882978.022174578 4797939.071553345 1.0 0.5144140366394969 0.2778490725955789 24.04161007647973 -10.038705688742352 0.17093032275565082 1.6843349809923611 5.823060497978581e-16 0.9996128086790567 0.005915012910547991 1.5894661892856512 0.07923546056920071 0.6650225249631758 0.17257255729404042 9.147329246771899e-11 10.038705688742352 -1.6843349809923605 AQAALAVNISAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQAALAVNISAAR 13 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 25899900.0 15350000.0 6960500.0 3589400.0 False True 12764205.12030011 6923002.404948929 4339926.944489538 1.0 0.5423763046504659 0.340007615326343 23.60560036218317 -13.32296129340581 0.11818457141461589 2.880820417942652 1.5588599727828964e-19 0.9997247552054727 0.004580238981652285 9.447825288940944 0.09874529689779003 4.383057651730891 0.28780521127252134 4.753775921905386e-14 13.32296129340581 -2.880820417942652 AQAALAVNISAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQAALAVNISAAR 13 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 180952800.0 74412800.0 69122000.0 37418000.0 False True 96328836.49557982 65275299.9368787 30608307.94110199 1.0 0.6776299009889313 0.31774813290209825 26.521464404560952 -7.215339445297046 0.3016789207465799 1.0717664532606015 8.60575647763186e-17 0.9999108823810248 0.0026306832138941 0.0920422851277806 0.016984781770411864 0.010239603653811111 0.04151398135224173 6.09060668311647e-08 7.215339445297046 -1.0717664532606015 down AQADFVK(ub)SAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQADFVKSAVR 11 1 Q9UFC0;F8WDB4;H7C5S6 Q9UFC0 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 1 49902800.0 7452800.0 13758000.0 28692000.0 True False 9647796.516651131 12992355.205746021 23470350.404781077 1.0 1.3466655503484672 2.4327161507058737 23.201768048751838 -6.950472890054111 0.5536307632494125 0.9852934517974085 2.8454278117802234 0.9992378524604854 0.016848974470733146 0.08329647281091936 0.03518123419198282 0.018203336662488093 0.09016049962767483 1.1207973874404606e-07 6.950472890054111 1.860134359982815 up AQADIYK(ub)ADFQAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQADIYKADFQAER 14 1 A0A087X0G7;A0A087WUW6;A0A087X1B1;Q9Y6K9;Q9Y6K9-2 A0A087X0G7 IKBKG NF-kappa-B essential modulator 1 20294200.0 4365400.0 8179100.0 7749700.0 True False 6622630.953488903 6719475.701400022 6217968.398185823 1.0 1.0146233043319588 0.9388970096408743 22.658973035526643 -6.856642905169455 1.2025396568531237 1.0078738162374188 0.9354575242840363 0.9494320519333037 0.007375582336632988 0.15030085556284012 0.4149264005873352 0.004789715540255641 0.011142006605607333 1.391095977568328e-07 6.856642905169455 -0.0724162919533825 AQAELNALK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQAELNALKR 10 1 F5H442;Q99816;Q99816-2 F5H442 TSG101 Tumor susceptibility gene 101 protein 1 7671000.0 1757200.0 3690300.0 2223500.0 True False 2665800.8685276723 3031737.1325544957 1784024.2504053279 1.0 1.137270667268156 0.6692263745081036 21.346137586541282 -6.828179228739364 1.3359459865281553 1.0734480060390799 0.6570870420336143 0.9021929208864954 0.06143681798204125 0.18307357965986282 0.6396461429613939 0.036113277096985294 0.08311873371254799 1.485322538882787e-07 6.828179228739364 -0.4163609640054655 AQAELNALK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQAELNALKR 10 1 F5H442;Q99816;Q99816-2 F5H442 TSG101 Tumor susceptibility gene 101 protein 1 3151710.0 910570.0 1583900.0 657240.0 True False 757179.3000906635 1575367.2163204649 794665.8452655879 1.0 2.0805735393609317 1.0495081484272428 19.530275445350654 -6.635146623508878 2.0615565811042815 1.709195469321538 1.0537079709009325 0.1364244410755474 0.4629044669258661 0.545710065949756 4.426254427820255 0.1832188866061904 0.5127571019561207 2.3166123992197627e-07 6.635146623508878 -0.6554874984206056 AQAELNALK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQAELNALKR 10 1 F5H442;Q99816;Q99816-2 F5H442 TSG101 Tumor susceptibility gene 101 protein 1 5759800.0 1757200.0 2221500.0 1781100.0 True False 2274730.0395904016 2097871.5721445545 1456958.0756292911 1.0 0.9222507882835657 0.6404971360432896 21.11726390863373 -6.947146174633582 0.5893507586189978 1.003262992723317 0.5453234878078279 0.9989578009843941 0.004985880426617054 0.08465253255420215 0.04086530065271772 0.005172507191433691 0.023599321042569926 1.1294157124800148e-07 6.947146174633582 -0.45793950491548907 AQAELVGTADEATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQAELVGTADEATR 14 0 P30049 P30049 ATP5D ATP synthase subunit delta, mitochondrial 0 24318400.0 4986300.0 9537100.0 9795000.0 False True 6537087.587397883 8114201.855324626 8781507.36027454 1.0 1.2412564076649493 1.3433363470918491 22.64021659662888 -13.418624395691305 0.1232212081005854 1.5524718401248472e-14 1.503933356080922 0.9996907974267766 0.0025313033306564405 9.802175058893225 0.10317468115730961 2.4799263475683944 0.1376214288072908 3.8139553487464796e-14 13.418624395691305 1.5039333560809065 AQAELVGTADEATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQAELVGTADEATR 14 0 P30049 P30049 ATP5D ATP synthase subunit delta, mitochondrial 0 19089900.0 5607300.0 2227600.0 11255000.0 False True 5429299.330780837 3117092.296780534 8306977.857237523 1.0 0.5741242298262154 1.5300276059825977 22.37233459475125 -6.785581525110406 1.5138804112599316 0.7606067011432764 1.5390020894836316 0.7867224444809868 0.18057953900795468 0.2419950658480882 1.095668471843206 0.09391403692672544 0.22060978982589413 1.6383944754559872e-07 6.785581525110406 0.7783953883403552 AQAELVGTADEATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQAELVGTADEATR 14 0 P30049 P30049 ATP5D ATP synthase subunit delta, mitochondrial 0 22627200.0 4986300.0 7959600.0 9681300.0 False True 6829869.859690798 7607918.553122671 7394776.332632247 1.0 1.1139185239859162 1.0827111620787198 22.70342665815177 -10.052429482755153 4.144390335341442 0.9999887511630777 1.0983148430722713 0.9297414038079815 0.012740352275560387 8896393.382518647 7780541.861594011 1165.3317865864803 0.004662492436638958 8.862791188516958e-11 10.052429482755153 0.09832609190919361 AQAELVGTADEATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQAELVGTADEATR 14 0 P30049 P30049 ATP5D ATP synthase subunit delta, mitochondrial 0 10302600.0 5607300.0 2454500.0 2240800.0 False True 4662718.395508715 2441277.1213198956 2709340.919711417 1.0 0.5235737855563859 0.581064668696515 22.152739870185528 -10.119256767632304 5.168345719612524 1.000012559805893 0.5523192271267116 0.9877824626314531 0.02347055476125176 3.3968070825093754e-06 5.789065311718567e-07 0.022725903723717765 0.007575088976088626 7.598768826112247e-11 10.119256767632304 -0.44769333267918154 AQAVSEDAGGNEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQAVSEDAGGNEGR 14 0 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 8611010.0 2436300.0 898410.0 5276300.0 False True 2358960.9900631937 1257149.7981462567 3894278.7443929208 1.0 0.5329252172638002 1.6508449104487302 21.169720130373904 -6.793215719545512 1.4833811493309708 0.7400336168550442 1.6638232109783782 0.8115851746926329 0.19899388383615912 0.23059792322421732 1.0022918638263674 0.10557000520497127 0.24660747921952622 1.6098458058405203e-07 6.793215719545512 0.923789594123334 AQAYQTGK(ub)DISTNYYASQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQAYQTGKDISTNYYASQK 19 1 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 1 8776380.0 1151200.0 876680.0 6748500.0 True False 1114655.7861350216 1226742.895825804 4980865.39933962 1.0 1.100557599112669 4.468523342627921 20.088166833456928 -6.913277420435595 0.8731293095398345 0.9062172743080619 4.935710207535654 0.9921005059422668 0.14326410999418993 0.1022901567764529 0.12731020924135808 0.11922719479546985 0.33709212335242567 1.2210194431175611e-07 6.913277420435595 4.029492933227592 up AQAYQTGK(ub)DISTNYYASQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQAYQTGKDISTNYYASQK 19 1 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 1 4736600.0 1151200.0 1444700.0 2140700.0 True False 957273.8068071335 1436917.1143495017 2588310.4725215207 1.0 1.5010513231759242 2.7038350512843397 19.868572108891204 -6.956325919700182 0.48444692322806365 0.9723039743518456 3.283108182328986 0.999608730164003 0.014142732754862315 0.08104064792315947 0.026186533555690585 0.01711482873899316 0.09920739162001035 1.1057936210196736e-07 6.956325919700182 2.3108042079771405 AQCNTK(ub)QCPCYLAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQCNTKQCPCYLAVR 15 1 Q15910-3;Q15910-4;Q15910;Q15910-2;Q15910-5 Q15910-3 EZH2 Histone-lysine N-methyltransferase EZH2 1 3924260.0 1216500.0 1982300.0 725460.0 True False 1594843.2806027578 1686548.5669448795 650396.3583037038 1.0 1.0575011272000734 0.4078120817350103 20.60498323193139 -6.885324747949283 1.0496949100722046 1.0389207503360047 0.35680454576048193 0.9777312449169886 0.043821012664708996 0.12301628386168693 0.24468999576104009 0.031989102459420445 0.07851513950370737 1.3021926869782248e-07 6.885324747949283 -0.6821162045755228 down AQCNTK(ub)QCPCYLAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQCNTKQCPCYLAVR 15 1 Q15910-3;Q15910-4;Q15910;Q15910-2;Q15910-5 Q15910-3 EZH2 Histone-lysine N-methyltransferase EZH2 1 14993900.0 2192600.0 4490400.0 8310900.0 True False 3326334.500531401 3689053.036344662 6668246.972203131 1.0 1.1090445160447076 2.004683224473618 21.66550182453759 -6.929608477266501 0.7499962759583484 0.9861810086039283 2.186735115255409 0.9964608505854378 0.026777797308969734 0.09284128015325638 0.07867884446052678 0.02433944542389649 0.08121476747716319 1.1759572195949659e-07 6.929608477266501 1.2005541066514804 up AQCNTK(ub)QCPCYLAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQCNTKQCPCYLAVR 15 1 Q15910-3;Q15910-4;Q15910;Q15910-2;Q15910-5 Q15910-3 EZH2 Histone-lysine N-methyltransferase EZH2 1 21281500.0 2192600.0 2459900.0 16629000.0 True False 2838363.922607511 2323004.402574114 13602692.627948718 1.0 0.8184307812227429 4.792441349611144 21.43662814663004 -6.896191231315546 0.9849944166708167 0.8170700888551109 5.178817866799747 0.9845754344800022 0.22753522323149677 0.11426482220352654 0.19363472478687827 0.17441179485753094 0.44572828917014434 1.2700147610727584e-07 6.896191231315546 4.361747777944636 up AQDALPFFMMHLGYEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQDALPFFMMHLGYEK 16 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 3783400.0 1274100.0 1497700.0 1011600.0 False True 1670357.4384019522 1274248.9979888743 906929.3359523983 1.0 0.762860073355294 0.5429552472434084 20.671725426174156 -6.9720320386805685 0.20390167052438635 1.1244805376916593 0.17523741100981485 0.9999941926517866 0.00044971684525287547 0.0756487327281274 0.006615634808304294 0.0069155234317377435 0.023120230144293687 1.0665174394293104e-07 6.9720320386805685 -0.9492431266818445 AQDALPFFMMHLGYEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQDALPFFMMHLGYEK 16 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 9409800.0 2648700.0 3210800.0 3550300.0 False True 2564618.468325076 4492889.1841008 2620369.9232830177 1.0 1.751874300053316 1.0217386935509172 21.290312785099335 -10.404248387949131 4.381806535845112 0.9990515260451263 1.3868064968034786 0.2723109200617857 0.2980766131660189 213737340.01795936 2660.985597304377 2045381.5759414295 0.10203893798691434 3.9423176288220767e-11 10.404248387949131 0.3877549707583523 AQDALPFFMMHLGYEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQDALPFFMMHLGYEK 16 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 48287000.0 15325000.0 17871000.0 15091000.0 False True 23249145.4075726 14681780.423239693 12108257.235379735 1.0 0.6314976385522374 0.5208044004678077 24.47067435080139 -13.999999999999998 0.16852857639628738 2.851318464763925 0.421614917015814 0.9995165629145422 0.004504096871516395 12.077564520853445 0.12996924784212155 7.308714428643725 0.09147049957450767 1.0000000000000041e-14 13.999999999999998 -2.4297035477481113 AQDALPFFMMHLGYEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQDALPFFMMHLGYEK 16 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 6611300.0 1274100.0 2342400.0 2994800.0 False True 1745169.201257858 2238905.0227190466 2287489.919842069 1.0 1.2829157316696402 1.3107553801621785 20.734935487697047 -12.412605712804593 0.3545708060555812 0.0034320432590299777 1.3145995662857826 0.9996746712852728 0.0025321975502450036 7.055600964017424 0.18785624887329644 5.158557247821767 0.008177512339240162 3.867179111139428e-13 12.412605712804593 1.3111675230267525 AQDALPFFMMHLGYEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQDALPFFMMHLGYEK 16 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 7027600.0 2648700.0 2028000.0 2350900.0 False True 2202511.4073054646 2017074.7614735186 2842462.320666532 1.0 0.9158067262594531 1.2905550959865304 21.07071806053361 -6.847702302020408 1.2461049528569774 0.9551448385861073 1.3048871805432998 0.9369013801194791 0.04032581521702415 0.15999908417716638 0.4792430553808472 0.02533712996117363 0.05855283938039218 1.420030583511112e-07 6.847702302020408 0.34974234195719245 AQDALPFFMMHLGYEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQDALPFFMMHLGYEK 16 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 35514200.0 15325000.0 11629000.0 8560200.0 False True 19838514.60091219 10981835.927287435 7002331.43506925 1.0 0.5535614005487327 0.3529665187103916 24.241800672893838 -13.412096693929671 0.11453709828157038 2.888370086351869 6.9092845602905865e-22 0.999740792287089 0.0043539217661883 9.771376073038379 0.09740795489168082 4.4112485701008035 0.30027845340788206 3.871714331533107e-14 13.412096693929671 -2.888370086351869 AQEEAK(ub)EAEMSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQEEAKEAEMSR 12 1 Q8WXX5 Q8WXX5 DNAJC9 DnaJ homolog subfamily C member 9 1 4821700.0 1010800.0 1700500.0 2110400.0 True False 978712.7072839462 2379518.51799035 1557622.929357094 1.0 2.431273754066012 1.591501691726981 19.900525905661404 -10.28004306802728 5.275970630852377 0.999839140746513 2.0113877228966066 0.6591656688858641 0.3428355088296079 0.0006487887345867732 8.853333482707884e-05 0.3320005597122115 0.11064968468207904 5.24755418830234e-11 10.28004306802728 1.0115485821500936 AQEEAK(ub)EAEMSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQEEAKEAEMSR 12 1 Q8WXX5 Q8WXX5 DNAJC9 DnaJ homolog subfamily C member 9 1 3617540.0 1010800.0 2019000.0 587740.0 True False 840524.986032531 2008123.2462598793 710633.7165972809 1.0 2.3891297458492904 0.8454641187427796 19.68093118109568 -6.669619408563914 1.93913613521418 1.8869788191974228 0.8517674343142821 0.2772374713892648 0.5901257295272158 0.46195823107276635 3.3486853920543678 0.2450541744197731 0.6549496256498915 2.1398365013041398e-07 6.669619408563914 -1.0352113848831408 AQEYLVHVAPHCANFLVPSQNLHLTLALLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQEYLVHVAPHCANFLVPSQNLHLTLALLR 30 0 A0A087WVD1;Q96B70 A0A087WVD1 LENG9 Leukocyte receptor cluster member 9 0 55377000.0 14570000.0 21252000.0 19555000.0 False True 22103755.20967917 17459414.557366118 15689945.678739043 1.0 0.7898845418682835 0.7098316792735951 24.39778815428776 -13.999999999999998 0.13374630792603115 1.9995637027679514 0.6028800052322922 0.9996289968375555 0.0023568833144745425 11.932735546725059 0.11408197509608635 3.1257830158599593 0.09526809736302758 1.0000000000000041e-14 13.999999999999998 -1.3966836975356591 AQEYLVHVAPHCANFLVPSQNLHLTLALLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQEYLVHVAPHCANFLVPSQNLHLTLALLR 30 0 A0A087WVD1;Q96B70 A0A087WVD1 LENG9 Leukocyte receptor cluster member 9 0 36930000.0 14570000.0 11585000.0 10775000.0 False True 18861152.217637263 10940284.565966533 8814060.560836343 1.0 0.5800432783600653 0.4673129435111722 24.16891447638021 -13.999999999999998 0.18458432786584217 3.2107170884875034 0.3818794354706447 0.9994933196085568 0.005159371298293444 12.26754832014684 0.13622938849636662 9.737931159872291 0.08100078846737603 1.0000000000000041e-14 13.999999999999998 -2.828837653016859 AQFEGIVTDLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQFEGIVTDLIR 12 0 P38646;H0YBG6 P38646 HSPA9 Stress-70 protein, mitochondrial 0 34397500.0 6750500.0 16915000.0 10732000.0 False True 8849970.871934986 14391347.9341536 9621555.588613208 1.0 1.6261463616554288 1.0871850007015358 23.077241276160024 -10.428494553602032 4.4175526005628045 0.9989343714205418 1.3566656811792757 0.3686511076482596 0.22003005423823582 0.002315875930520024 0.00029960872142916715 0.21365428872580677 0.07101439464376792 3.7282536043996997e-11 10.428494553602032 0.3577313097587339 AQFEGIVTDLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQFEGIVTDLIR 12 0 P38646;H0YBG6 P38646 HSPA9 Stress-70 protein, mitochondrial 0 47353700.0 17134000.0 7912700.0 22307000.0 False True 16590090.548677424 11072282.374185383 16464127.504344517 1.0 0.6674033720128233 0.9924073323190542 23.983818424753135 -10.784533941630004 9.750378187938272 1.0013483886648211 0.8299053522851563 0.267511987550651 0.13268231118900398 0.003916375670521767 8.654480788091882e-05 0.12936933247491778 0.04282303179761017 1.6423512991708576e-11 10.784533941630004 -0.17144303637966485 AQFEGIVTDLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQFEGIVTDLIR 12 0 P38646;H0YBG6 P38646 HSPA9 Stress-70 protein, mitochondrial 0 42021500.0 6750500.0 16711000.0 18560000.0 False True 9246342.275403153 15972652.764112877 14176510.255198633 1.0 1.7274563593219836 1.5332019768412173 23.140451337682915 -10.14327249523697 4.659591149908557 0.9999364053056174 1.6303291680883534 0.9335056050878306 0.07930401959019988 55438960.80533969 4.540291163532218 38189.62885006083 0.027147875264886195 7.189977060286839e-11 10.14327249523697 0.6303927627827359 AQFEGIVTDLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQFEGIVTDLIR 12 0 P38646;H0YBG6 P38646 HSPA9 Stress-70 protein, mitochondrial 0 29131400.0 17134000.0 5837500.0 6159900.0 False True 14247680.164900465 5806052.228846971 7447906.609840389 1.0 0.407508602217948 0.5227452135112145 23.76422370018741 -9.979866053913945 6.213511986650013 1.0000002452653807 0.46512690786509703 0.9663582270863855 0.0470451495594337 1.5983215084800909e-07 2.6217730372830932e-08 0.04555129055326643 0.01518375673027766 1.0474515556140645e-10 9.979866053913945 -0.5348733374002836 AQFFLGTTNKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQFFLGTTNKR 11 1 Q9NVT9;E5RJ86 Q9NVT9 ARMC1 Armadillo repeat-containing protein 1 0 8827100.0 2866900.0 1857600.0 4102600.0 False True 3758533.663099091 1580453.3208680856 3678102.306918056 1.0 0.4204973169150562 0.9786003363570475 21.84173849463593 -10.854505112735685 10.52663305192968 1.0088349198763724 0.699548826636052 0.2787170178177526 0.22784460358991304 0.046501044358341806 0.0006427174219730145 0.217147139033548 0.07353652960224699 1.3979604577238734e-11 10.854505112735685 -0.3092860932403204 AQFFLGTTNKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQFFLGTTNKR 11 1 Q9NVT9;E5RJ86 Q9NVT9 ARMC1 Armadillo repeat-containing protein 1 0 5479200.0 2866900.0 1566200.0 1046100.0 False True 3926870.4050593744 1497000.105269201 799032.7251057797 1.0 0.3812196357028916 0.20347825180996731 21.90494855615882 -13.999999999999908 0.17493289978427887 4.162866594420443 0.054649019117299455 0.9995051339183614 0.007594432217223556 12.143357279283904 0.1325302933539594 13.041526125784852 0.13865189066050337 1.0000000000002127e-14 13.999999999999908 -4.108217575303144 AQFFLHLSPSHYALLQYHYGTLSLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQFFLHLSPSHYALLQYHYGTLSLLK 26 0 Q8N766-3;Q8N766-2;Q8N766;Q8N766-4 Q8N766-3 EMC1 ER membrane protein complex subunit 1 0 311080000.0 43476000.0 133864000.0 133740000.0 False True 65956270.521346 109974923.31579423 107306230.37967564 1.0 1.667391476905931 1.6269299269270718 25.975006488510328 -10.176447888377133 4.769877361382835 0.99992366251496 1.6471607019196426 0.9970768526532101 0.016518358619367634 1.3412068921913498e-05 2.315670324791954e-06 0.01599570696467004 0.00533127731839893 6.661194451386594e-11 10.176447888377133 0.6472370394046826 AQFFLHLSPSHYALLQYHYGTLSLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQFFLHLSPSHYALLQYHYGTLSLLK 26 0 Q8N766-3;Q8N766-2;Q8N766;Q8N766-4 Q8N766-3 EMC1 ER membrane protein complex subunit 1 0 192883300.0 43476000.0 47652300.0 101755000.0 False True 56280539.04008218 45000407.615261786 83236634.09446885 1.0 0.799573145225442 1.4789594327657192 25.746132810602777 -6.827687738820032 1.338127906187017 0.8927194312734941 1.4964028168981391 0.9011824377751578 0.08959746562027897 0.18368474127957043 0.6440455805443915 0.05258312336693532 0.12103098728285125 1.4870044259952806e-07 6.827687738820032 0.6036833856246451 AQFLQNLLLPQAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQFLQNLLLPQAKR 14 1 O94927;O94927-2 O94927 HAUS5 HAUS augmin-like complex subunit 5 1 11278200.0 1139600.0 2501600.0 7637000.0 True False 1103424.0217855012 3500501.9256716645 5636640.594910967 1.0 3.172399600298117 5.108317821276049 20.07355586304048 -7.274560088859765 0.22194745540696223 5.446883456401047e-18 7.751298107534548 0.9999702623486177 0.009151269596541714 0.10711892827723056 0.01370287451371777 0.11441961360571554 0.3153406817282744 5.314224669599168e-08 7.274560088859765 7.751298107534548 AQFLQNLLLPQAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQFLQNLLLPQAKR 14 1 O94927;O94927-2 O94927 HAUS5 HAUS augmin-like complex subunit 5 1 9263400.0 1139600.0 3230700.0 4893100.0 True False 947627.8928399998 3213295.5778562617 5916224.586861802 1.0 3.3908832803835627 6.243193801663154 19.853961138474755 -6.968783060509017 0.2857598012727466 0.4136432255534367 9.308041133403238 0.999971273968793 0.01148729873183453 0.07669956137741174 0.01043665080479512 0.05099806608254915 0.25995628010200206 1.0745260273059486e-07 6.968783060509017 8.894397907849802 AQFLVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQFLVEK 7 0 Q99623;J3KPX7;F5GY37;F5GWA7 Q99623 PHB2 Prohibitin-2 0 11755800.0 1479200.0 5945500.0 4331100.0 False True 1939245.524593175 5058454.575377478 3882959.318844832 1.0 2.6084652568367623 2.0023041278692237 20.88706404150979 -10.28195261353397 5.405079813077091 0.9998283570174205 2.3053846923530394 0.8607935377562518 0.24746424464688976 0.0005119249721419131 6.800762319236326e-05 0.23963661778043852 0.07986874152489773 5.2245319147288755e-11 10.28195261353397 1.305556335335619 AQFLVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQFLVEK 7 0 Q99623;J3KPX7;F5GY37;F5GWA7 Q99623 PHB2 Prohibitin-2 0 10430200.0 1479200.0 4589200.0 4361800.0 False True 2026100.2138769485 4386433.96954502 3331632.6740908003 1.0 2.164963973401674 1.6443572984554953 20.950274103032683 -10.573888473644622 5.678277790340204 0.9965572453389308 1.9046606359285845 0.8010408176672474 0.21253678505085447 0.009279499238006455 0.0006963551330946119 0.20615111336766917 0.06859595241320185 2.667543598896746e-11 10.573888473644622 0.9081033905896537 AQFTAQVHHFMELCWDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQFTAQVHHFMELCWDK 17 0 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 0 88601300.0 18506300.0 29475000.0 40620000.0 False True 28075410.09175605 24214955.96077388 32591439.195621554 1.0 0.8624969637713061 1.1608535401301787 24.74280376014184 -6.781407577251016 1.5305425540397168 0.922284246294683 1.1633154843081661 0.7722847782945139 0.058183377086035624 0.24839560881733105 1.1494370884537717 0.02993953654454214 0.0705574506462485 1.654216783246979e-07 6.781407577251016 0.24103123801348314 AQFTAQVHHFMELCWDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQFTAQVHHFMELCWDK 17 0 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 0 68730300.0 18506300.0 28089000.0 22135000.0 False True 23956770.163710397 26525822.457784545 18106657.124279566 1.0 1.1072370055111076 0.7558054362314435 24.51393008223429 -6.824820400227483 1.3509029560022365 1.0575353966439804 0.7473113619071576 0.895112028571747 0.04762686032866089 0.18728977838144198 0.6702475515907269 0.027695000278653712 0.06376508074271568 1.4968545429714415e-07 6.824820400227483 -0.3102240347368228 AQGIAPEDK(ub)AIQAELLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQGIAPEDKAIQAELLK 17 1 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 24527900.0 6412400.0 9389100.0 8726400.0 True False 8406718.497769931 7988282.878425157 7823475.83753955 1.0 0.9502260460540253 0.9306218400931232 23.003111334031033 -13.999999999999998 0.12872133064594618 1.2365132874876894 0.9027163995979669 0.9996514042548729 0.0005452020488425282 11.938955295996044 0.11144365264493204 0.715260194623448 0.024806130565509562 1.0000000000000041e-14 13.999999999999998 -0.3337968878897225 AQGIAPEDK(ub)AIQAELLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQGIAPEDKAIQAELLK 17 1 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 41223000.0 14948000.0 11046000.0 15229000.0 True False 14473483.922121504 15456725.404129036 11240068.039792994 1.0 1.0679339879256526 0.7765972657497822 23.786908899984734 -6.845280421825382 1.257606135913486 1.0361545001254382 0.7659661111890476 0.9331619789629156 0.03217535221384861 0.1627217532947214 0.4976149420268565 0.020041806503282963 0.046260426543158754 1.4279716264671094e-07 6.845280421825382 -0.27018838893639063 AQGIAPEDK(ub)AIQAELLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQGIAPEDKAIQAELLK 17 1 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 90245000.0 19332000.0 16422000.0 54491000.0 True False 29328057.358511865 13491365.79432837 43720829.965746306 1.0 0.4600156645019919 1.490750970352192 24.80577817676361 -6.764346984738072 1.5959787715418328 0.688043615191235 1.4953628935748704 0.7084807111752398 0.22728472754118634 0.27568892849981286 1.3848796368126 0.11231037029506688 0.26876788291827003 1.720493417045499e-07 6.764346984738072 0.8073192783836354 AQGIAPEDK(ub)AIQAELLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQGIAPEDKAIQAELLK 17 1 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 25892600.0 6412400.0 9855000.0 9625200.0 True False 8783237.568594208 9419573.513873052 7351925.997216475 1.0 1.0724489051228854 0.8370405490914189 23.066321395553924 -6.824074284702623 1.3541216504354794 1.0388971376630487 0.831436770326866 0.8935048728281098 0.03212594651891464 0.18823987645512014 0.6770839076382835 0.018637663904998235 0.04291805223891089 1.49942834107383e-07 6.824074284702623 -0.20746036733618267 AQGIAPEDK(ub)AIQAELLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQGIAPEDKAIQAELLK 17 1 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 39169000.0 14948000.0 17993000.0 6228000.0 True False 12429924.308680514 17896068.137669127 7530246.004981557 1.0 1.439756807301819 0.6058159179394812 23.56731417541901 -6.763452532023049 1.5996571589909585 1.2543418784004587 0.6022590647092413 0.7048132431427123 0.1850649307280841 0.27716600966554567 1.3985986839642635 0.09125133652548201 0.21853428022634758 1.7240405167305933e-07 6.763452532023049 -0.6520828136912175 AQGIAPEDK(ub)AIQAELLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQGIAPEDKAIQAELLK 17 1 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 102359000.0 19332000.0 19111000.0 63916000.0 True False 25025655.090690713 18047456.05008083 52283943.83354198 1.0 0.7211581868557877 2.0892137945668035 24.57690449885606 -6.853633430203658 1.2175634563170972 0.8506133801143977 2.147815805905404 0.9454086471756864 0.13791420682632524 0.15350821728358516 0.4361188602115931 0.08854807053209765 0.20542205418701398 1.4007691543541197e-07 6.853633430203658 1.2972024257910064 up AQGPLAMLQHFDTIYSILHHFR ddPTM_RPMI8226_Bortezomib_8h_R1 2 AQGPLAMLQHFDTIYSILHHFR 22 0 Q15021;F5GZK7 Q15021 NCAPD2 Condensin complex subunit 1 0 3365165000.0 1067545000.0 1132461000.0 1165159000.0 False True 1619543812.9936116 930364486.5918219 934864812.942668 1.0 0.5744608321970057 0.5772395939166578 30.592940351408412 -10.523768592113518 9.398382935440633 1.000014181237028 0.5758502130568353 0.9999678098766874 0.0011344247216543853 3.371003278596061e-07 1.708109121390003e-08 0.001098438631088536 0.00036613400454112296 2.993859448824068e-11 10.523768592113518 -0.42416396818019275 AQGPLAMLQHFDTIYSILHHFR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AQGPLAMLQHFDTIYSILHHFR 22 0 Q15021;F5GZK7 Q15021 NCAPD2 Condensin complex subunit 1 0 2932179000.0 1067545000.0 789564000.0 1075070000.0 False True 1381958046.9579647 745624069.3174634 879418291.1497287 1.0 0.5395417545118454 0.6363567208755347 30.36406667350086 -9.998719642800733 5.951380300328154 1.0000004528459931 0.5879492376936523 0.9602419125439914 0.03952454450950674 2.3748703744337774e-07 3.9956913502027766e-08 0.038269517860571416 0.012756491887614773 1.0029524814138708e-10 9.998719642800733 -0.4120512151523409 AQHEDQVEQYK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQHEDQVEQYKK 12 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 5327400.0 1254500.0 2614700.0 1458200.0 True False 1644661.648595281 2224596.9520207704 1307319.4520420965 1.0 1.3526167852949067 0.7948865671906977 20.64935938240213 -6.735823424472908 1.7018184419057958 1.210810255744304 0.794836907268924 0.5861416594513216 0.14817640775948934 0.3254163332490566 1.8488126169199122 0.06892541312101724 0.16992946312239343 1.8372851952493776e-07 6.735823424472908 -0.4159733484753799 AQHEDQVEQYK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQHEDQVEQYKK 12 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 7508700.0 2339100.0 2526100.0 2643500.0 True False 2264846.550858609 3534784.903437475 1951088.0466999027 1.0 1.5607171718090258 0.8614658886979519 21.110981876631143 -6.693301026537247 1.8557918270617086 1.350462737334855 0.8638547908116347 0.3854733768972981 0.23698980850694795 0.4095801420984702 2.7376355682787983 0.10209025480842404 0.2646411599010453 2.0262777400876436e-07 6.693301026537247 -0.48660794652322026 AQHEDQVEQYK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQHEDQVEQYKK 12 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 17574500.0 4420800.0 4166800.0 8986900.0 True False 6706676.803771428 3423201.984643005 7210635.275901806 1.0 0.5104170194570885 1.0751427997614231 22.677166649261014 -6.677453106356295 1.9106291450210764 0.6895216560720253 1.0729633972028523 0.31247660403873334 0.2076153591962708 0.44430523237648123 3.133517472172944 0.08725690503897883 0.23091382164737892 2.1015846787746872e-07 6.677453106356295 0.38344174113082696 AQHEDQVEQYK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQHEDQVEQYKK 12 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 5960300.0 2339100.0 2303000.0 1318200.0 True False 1945065.2896999365 2290593.2818902903 1593829.5253318397 1.0 1.1776433901834 0.819422121083513 20.89138715206542 -6.771916500244739 1.5676080786037867 1.1016443563594747 0.8172834622134152 0.7376563418796928 0.07490587547914368 0.2633458820612315 1.277501682858506 0.0376619556332103 0.08947643012523897 1.6907659760085168e-07 6.771916500244739 -0.2843608941460595 AQHEDQVEQYKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQHEDQVEQYKK 12 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 11606900.0 3617300.0 1158500.0 6831100.0 False True 3502470.791509915 1621095.0914976886 5041829.981392736 1.0 0.46284328635295613 1.4395066458838912 21.73994158882552 -6.75738350044158 1.6223194580031204 0.6869786890560515 1.4426214093019585 0.6802087512941406 0.2258525182492481 0.287328699865421 1.4898294937945953 0.10987503387372058 0.2647337025901936 1.7483021818380626e-07 6.75738350044158 0.755642720245907 AQIAGYLYGVSPPDNPQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQIAGYLYGVSPPDNPQVK 19 0 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 5585100.0 2066900.0 0.0 3518200.0 False True 2709725.915888074 0.0 3154170.412957423 1.0 0.0 1.164018247920727 21.36971550216295 -10.675216408697835 4.562747770977249 1.0137803786294863 0.5820091239616688 0.14670703167575938 0.4752084597824875 0.06739547713397832 0.004797312759343836 0.4655079151651553 0.15337287089285556 2.1124361517767573e-11 10.675216408697835 -0.4317712546678175 AQIAGYLYGVSPPDNPQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQIAGYLYGVSPPDNPQVK 19 0 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 4865400.0 2066900.0 1229600.0 1568900.0 False True 2831088.785872276 1175272.20625655 1198358.1325097596 1.0 0.41513081897021514 0.42328525282916485 21.432925563685842 -10.43328331976575 6.690458225911788 1.0000938473981773 0.41920803589970634 0.9998521760519382 0.003329033682616921 4.660919420827775e-06 3.947995984025099e-07 0.003223837106876127 0.0010744410009782292 3.687369679387817e-11 10.43328331976575 -0.580885811498471 AQIDPVLLK(ub)NSSQQDNSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQIDPVLLKNSSQQDNSSR 19 1 Q96T23-2;Q96T23;H0YER1;H0YCN2;H7C306 Q96T23-2 RSF1 Remodeling and spacing factor 1 1 35042600.0 19761000.0 12168000.0 3113600.0 True False 25906862.36579623 10352581.830492502 2791434.53976017 1.0 0.3996077056463847 0.10774884663167805 24.626830962500257 -8.88846900938026 0.3194047326586555 1.2107009981289572 4.456767639012544e-17 0.9983590164252222 0.015047019077014211 0.3909960090181925 0.1080946276226499 0.19009538767764367 0.08968375957692422 1.292798949759669e-09 8.88846900938026 -1.2107009981289572 AQIDPVLLK(ub)NSSQQDNSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQIDPVLLKNSSQQDNSSR 19 1 Q96T23-2;Q96T23;H0YER1;H0YCN2;H7C306 Q96T23-2 RSF1 Remodeling and spacing factor 1 1 37041900.0 20933000.0 9827400.0 6281500.0 True False 20268493.373144902 13751532.069213977 4636186.709039316 1.0 0.6784683901288051 0.2287385955969531 24.27273551651531 -7.279266195464276 0.40372151404793843 1.0302147289033698 5.807239883391638e-12 0.9995075477325063 0.007019377146715563 0.09922779750266543 0.031318022598685255 0.011278834737689336 0.05063584916932492 5.2569494936336886e-08 7.279266195464276 -1.0302147288975627 down AQIDPVLLK(ub)NSSQQDNSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQIDPVLLKNSSQQDNSSR 19 1 Q96T23-2;Q96T23;H0YER1;H0YCN2;H7C306 Q96T23-2 RSF1 Remodeling and spacing factor 1 1 69308000.0 38167000.0 19711000.0 11430000.0 True False 57902129.381456785 16193418.04725407 9170855.490053024 1.0 0.2796687828278735 0.15838546160601133 25.787113069275428 -13.999999999999998 0.25066916764612845 6.026511290558661 0.10992882182838475 0.999543950341189 0.007932833064621458 14.024637248989277 0.15842808157003804 35.51048651527442 0.05576417917402019 1.0000000000000041e-14 13.999999999999998 -5.916582468730276 AQIDPVLLK(ub)NSSQQDNSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQIDPVLLKNSSQQDNSSR 19 1 Q96T23-2;Q96T23;H0YER1;H0YCN2;H7C306 Q96T23-2 RSF1 Remodeling and spacing factor 1 1 47916700.0 20933000.0 21690000.0 5293700.0 True False 17406716.989136316 21573151.664872065 6400588.194696676 1.0 1.239357868478936 0.3677079485287972 24.053140791949588 -6.8335089031389264 1.3122399860274798 1.1276170096149931 0.3425393632645898 0.9126972167224774 0.10864579462110156 0.17652107283156226 0.5932358694423482 0.0649831513106785 0.1495433927215997 1.4672060085315177e-07 6.8335089031389264 -0.7850776463504033 down AQIDPVLLK(ub)NSSQQDNSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQIDPVLLKNSSQQDNSSR 19 1 Q96T23-2;Q96T23;H0YER1;H0YCN2;H7C306 Q96T23-2 RSF1 Remodeling and spacing factor 1 1 65996700.0 38167000.0 18406000.0 9423700.0 True False 49407933.88404679 17381689.919825643 7708683.295327458 1.0 0.3517995705025418 0.1560211627836657 25.558239391367877 -13.162142514184627 0.18082098036546612 3.459325795064457 1.6497579649971978e-19 0.9994728819587498 0.008280807460368758 8.855840186315021 0.12958908609551398 7.834674711709181 0.14362216337105338 6.884263514531087e-14 13.162142514184627 -3.459325795064457 AQIEQVIANCEHK(ub)NLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQIEQVIANCEHKNLR 16 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 25699500.0 3738500.0 10302000.0 11659000.0 True False 5671577.820959884 8463527.610106617 9354593.539678771 1.0 1.4922703835304532 1.649381148418335 22.43531871504052 -11.581405151995387 0.2014980634740953 5.1790139267660284e-11 1.7648599899904507 0.9993864204169456 0.006852233791640756 4.254494560432347 0.12057556174235803 1.9410017364486036 0.09786734201104237 2.621771559491737e-12 11.581405151995387 1.7648599899386606 AQIEQVIANCEHK(ub)NLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQIEQVIANCEHKNLR 16 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 22176900.0 3738500.0 5273400.0 13165000.0 True False 4839561.94685222 4979930.65430885 10769105.08430723 1.0 1.0290044241603167 2.225223109565059 22.20644503713297 -6.912115584926699 0.8811984015697216 0.9653944546536761 2.387022720971935 0.9916958432539924 0.05202103570767337 0.10303585710349857 0.13129974242160158 0.04304087630834237 0.12062910245480278 1.2242903182206877e-07 6.912115584926699 1.421628266318259 up AQILGGANTPYEK(ub)GVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQILGGANTPYEKGVFK 17 1 Q9NPD8 Q9NPD8 UBE2T Ubiquitin-conjugating enzyme E2 T 1 15395800.0 3902400.0 3246800.0 8246600.0 True False 3778520.4480657615 4543264.171838322 6086568.067302972 1.0 1.2023923740214335 1.6108336982584568 21.849389999512812 -6.959868965112038 0.437282546024033 0.9849751231866887 1.84410368281981 0.9997652924977323 0.0038921918080912967 0.07974805099437386 0.021305072865825586 0.005367441677205344 0.03385983936547646 1.0968090743393774e-07 6.959868965112038 0.8591285596331214 AQILGGANTPYEK(ub)GVFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQILGGANTPYEKGVFK 17 1 Q9NPD8 Q9NPD8 UBE2T Ubiquitin-conjugating enzyme E2 T 1 13075300.0 3902400.0 4296000.0 4876900.0 True False 3245018.505632518 4272856.59531077 5896637.241762136 1.0 1.3167433676862519 1.8171351662639488 21.62979527494709 -6.964381657871325 0.3685137394153848 0.9608652514206371 2.1903904823837137 0.9998998216233661 0.0033669007034696765 0.07817145857368304 0.015603859595246817 0.006610820735264724 0.0425321577358521 1.0854712924720417e-07 6.964381657871325 1.2295252309630766 AQILGGANTPYEK(ub)GVFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQILGGANTPYEKGVFK 17 1 Q9NPD8 Q9NPD8 UBE2T Ubiquitin-conjugating enzyme E2 T 1 42237000.0 4756100.0 5485900.0 31995000.0 True False 6156865.206747046 5180604.842506328 26172238.296423096 1.0 0.8414354819444682 4.250903246629804 22.553764553065367 -6.895994662032961 0.9862542886037178 0.8422522788645933 4.58103205313518 0.9844656650303494 0.19582918351229964 0.11441348277407014 0.1945182031511437 0.14997163866480917 0.3829165571737473 1.2705897220875445e-07 6.895994662032961 3.738779774270587 up AQIPK(ub)MEQELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQIPKMEQELK 11 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 113186000.0 39942000.0 45554000.0 27690000.0 True False 52364348.79887821 38757520.76810119 24824904.421235573 1.0 0.7401509167422605 0.47408026626251853 25.642081580632283 -6.970829680159011 0.2375395884822715 1.0985015225263532 0.10805731902833665 0.9999881485171432 0.0007391406186068928 0.0760344278010336 0.008060800011478924 0.0064724011840585575 0.026054269219452045 1.0694742190329412e-07 6.970829680159011 -0.9904442034980165 down AQIPK(ub)MEQELK ddPTM_RPMI8226_Bortezomib_2h_R1 2 AQIPKMEQELK 11 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 156117000.0 60516000.0 50993000.0 44608000.0 True False 58594952.704783715 71354770.82498205 32923826.588685162 1.0 1.2177630927442769 0.561888440367275 25.804273062282473 -6.817212518082685 1.3838691902132643 1.1177172168083342 0.5484070096465389 0.877842565112298 0.09532899956788464 0.19713914418439996 0.7425824492899766 0.054141762116276436 0.12489164606550844 1.5233071547866135e-07 6.817212518082685 -0.5693102071617954 AQIPK(ub)MEQELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQIPKMEQELK 11 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 92607000.0 42232000.0 38158000.0 12217000.0 True False 64069031.57276396 31348406.77018519 9802304.595098676 1.0 0.4892910974404605 0.15299598502540315 25.933123848006513 -8.304103409789349 0.32428399090817556 1.1323535575158261 5.3430180704214286e-21 0.9985578281377426 0.013224096611116776 0.10986746148929238 0.08113740822064533 0.08701216769806915 0.09198551727696401 4.964740920087717e-09 8.304103409789349 -1.1323535575158261 AQIPK(ub)MEQELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQIPKMEQELK 11 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 117760000.0 39942000.0 40611000.0 37207000.0 True False 54709636.79196399 38816671.737381876 28419472.902218472 1.0 0.7095033711333915 0.5194600909211823 25.705291642155174 -8.499053911055086 0.11329136160637002 1.5205889837987883 3.958429705487875e-09 0.9999662948243865 0.001147193945278821 0.1504461600677848 0.02755891342541243 0.1834403077912508 0.1640043044526036 3.169174033866039e-09 8.499053911055086 -1.5205889798403585 AQIPK(ub)MEQELK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AQIPKMEQELK 11 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 165780300.0 60516000.0 82726000.0 22538300.0 True False 50321735.31336042 82280338.61817455 27250954.324674983 1.0 1.6350854775933992 0.5415344712375182 25.58467833771675 -6.749258373379268 1.6526118367437768 1.3737665412589004 0.5394852509269337 0.6457812032565913 0.26685736947773225 0.3013320511064178 1.6189800145139475 0.12757269788813985 0.30995085897434926 1.7813186981079587e-07 6.749258373379268 -0.8342812903319667 AQIPK(ub)MEQELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQIPKMEQELK 11 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 76946900.0 42232000.0 27994000.0 6720900.0 True False 54670156.51717618 26436109.29129631 5497765.162257539 1.0 0.4835564954527002 0.10056245514004081 25.704250170098963 -8.134244833824098 0.4023935467186928 1.068419901102353 8.308380172063014e-19 0.9971299390843342 0.019743698376534852 0.0974870485729544 0.09822182515123996 0.057116811788941936 0.08251456896235454 7.3409990213755356e-09 8.134244833824098 -1.068419901102353 AQIPK(ub)MEQELKEPGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 AQIPKMEQELKEPGR 15 2 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 72104800.0 24763400.0 27096600.0 20244800.0 True False 32465057.209106736 23053892.90171956 18150062.297834206 1.0 0.7101140390183184 0.5590645407131133 24.952384415859758 -13.999999999995994 0.08246998339039395 2.540796823714365 0.12790710737304373 0.9998762800404354 0.0020350619655702842 12.234174565468761 0.08151001044741275 3.4014676030358073 0.39040012733099905 1.0000000000092234e-14 13.999999999995994 -2.412889716341321 AQIPK(ub)MEQELKEPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQIPKMEQELKEPGR 15 2 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 14814000.0 6678100.0 4384400.0 3751500.0 True False 6466107.370907124 6135113.78434396 2768869.607412402 1.0 0.9488109974708432 0.42821274819381167 22.62446603320468 -6.925921970840439 0.7795380471724129 1.009226828297766 0.33164893994980454 0.9956742674450793 0.016990073419131568 0.0948112860795178 0.08846364260159562 0.015118498236000732 0.048204460418123964 1.1859818129310296e-07 6.925921970840439 -0.6775778883479615 down AQIPK(ub)MEQELKEPGR ddPTM_RPMI8226_Bortezomib_8h_R1 2 AQIPKMEQELKEPGR 15 2 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 204971000.0 91617000.0 72793000.0 40561000.0 True False 138989687.09987485 59802520.41569502 32544100.57148213 1.0 0.4302658827681386 0.23414759217420694 27.050402599444556 -13.999999999999215 0.1487976275346707 3.7499288648602995 0.015367048882214721 0.9995703028447854 0.006733296231452644 11.953412053727675 0.12142203539630432 9.507525151657873 0.19697152625573353 1.0000000000018079e-14 13.999999999999215 -3.734561815978085 AQIPK(ub)MEQELKEPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AQIPKMEQELKEPGR 15 2 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 78977600.0 24763400.0 32551500.0 21662700.0 True False 33919098.18572234 31113267.09658429 16546416.417310959 1.0 0.917278723809965 0.4878200572052911 25.01559447738265 -6.938969706791137 0.6690792492764464 1.0049170361837443 0.3754362366791023 0.998025823109297 0.009974956900346298 0.08823980526605987 0.05677365908988848 0.009635692519028096 0.03713358160469175 1.1508806631681768e-07 6.938969706791137 -0.629480799504642 down AQIPK(ub)MEQELKEPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AQIPKMEQELKEPGR 15 2 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 80250600.0 31629100.0 35201900.0 13419600.0 True False 26300998.05670909 35012260.37766991 16225576.314780105 1.0 1.3312141349989064 0.6169186538014721 24.648614211415207 -6.780595460326176 1.5333331806664277 1.187394510538144 0.6111317268992044 0.7695720648067151 0.14010419992446912 0.24964481628523516 1.1593282395798903 0.07196085011095425 0.1697285118021131 1.6573130102551546e-07 6.780595460326176 -0.5762627836389397 AQIPK(ub)MEQELKEPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AQIPKMEQELKEPGR 15 2 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 204492000.0 91617000.0 89885000.0 22990000.0 True False 118600012.54106198 84882820.7347348 18806055.89732039 1.0 0.7157066758770069 0.15856706499764756 26.821528921537006 -7.247955575387849 0.5279818349134828 1.0076834121028753 4.232838290798696e-24 0.9985376114940016 0.013364591298264084 0.09357554607169292 0.047162598157934214 0.014106997969403134 0.0533398968732324 5.649947659901675e-08 7.247955575387849 -1.0076834121028753 down AQK(ub)LLVGVDEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQKLLVGVDEK 11 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 1 2465450.0 957820.0 665790.0 841840.0 True False 1255711.2955420741 566456.7272290931 754734.4722994914 1.0 0.45110426993854597 0.6010413977949306 20.26007337721064 -10.520803330794978 9.496076834953588 1.0000133420699702 0.5260728338668096 0.9301734815682096 0.06121157612443068 1.7290779599745967e-05 8.725994495104133e-07 0.05926951699040776 0.01975595124375231 3.014370765658514e-11 10.520803330794978 -0.4739405082031606 AQK(ub)LLVGVDEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQKLLVGVDEK 11 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 1 3496670.0 575870.0 1023300.0 1897500.0 True False 557589.3220653004 1431909.0264390043 1400487.8262201883 1.0 2.568035236283292 2.5116833676670987 19.08884340804103 -10.193602216281175 4.7839560178702385 0.9997863802751338 2.5398593019806333 0.9989965866897853 0.023005554047167764 8081131.417439698 7.540644831279195 19018.875630368497 0.007875413059173476 6.403210567895635e-11 10.193602216281175 1.5400729217054994 AQK(ub)LLVGVDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQKLLVGVDEK 11 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 1 3065970.0 957820.0 604750.0 1503400.0 True False 1311951.9381122363 578030.145359181 1148327.8834949129 1.0 0.4405878969856981 0.8752819749992049 20.323283438733533 -9.894967105298834 6.607977961544621 1.0000000170637982 0.657934935992448 0.4522457454908152 0.17746311422382124 4.463634586298042e-08 7.362052362811133e-09 0.17182792917001746 0.057275973829574195 1.2735995434207692e-10 9.894967105298834 -0.34206508107135014 AQK(ub)PGSSGLAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQKPGSSGLAAR 12 1 Q969F8 Q969F8 KISS1R KiSS-1 receptor 1 2485920.0 334990.0 501130.0 1649800.0 True False 324355.92581425566 701233.822358426 1217667.8870609044 1.0 2.161926965256037 3.754110192388497 18.307218270782737 -6.966716528751465 0.3272558669703225 0.7997087920531845 5.168237856625581 0.9999442818358764 0.00842681351494458 0.07738320147146861 0.012831481615208607 0.02346509043542098 0.13918526693666214 1.0796511986294661e-07 6.966716528751465 4.368529064572396 AQK(ub)PGSSGLAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQKPGSSGLAAR 12 1 Q969F8 Q969F8 KISS1R KiSS-1 receptor 1 3548730.0 558870.0 641460.0 2348400.0 True False 847846.648869827 526986.4512501444 1884237.710659713 1.0 0.6215586886527337 2.2223803245214064 19.69344382068555 -6.844381001107631 1.2620132297128253 0.7986537908169564 2.279725079264561 0.9317067190480435 0.17852356598286212 0.16374714163440443 0.5047142199447908 0.11083799810834187 0.25571286421764133 1.4309320097422385e-07 6.844381001107631 1.4810712884476047 up AQK(ub)PGSSGLAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQKPGSSGLAAR 12 1 Q969F8 Q969F8 KISS1R KiSS-1 receptor 1 2034800.0 558870.0 698510.0 777420.0 True False 723468.2319746686 659637.3044603625 635937.5370028191 1.0 0.9117709324429037 0.8790123863034884 19.464570142778 -13.9999998834531 0.1376120308105283 1.4206515372845268 0.837281500336588 0.9996126113117255 0.0010056279671691495 11.932314087586132 0.11604487943295667 1.34975945592794 0.037250225776003405 1.0000002683591909e-14 13.9999998834531 -0.5833700369479388 AQLADSFHLQQFFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQLADSFHLQQFFR 14 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 5078400.0 961500.0 2477800.0 1639100.0 False True 1260535.8111792454 2108121.898388753 1469501.6553574302 1.0 1.672401434130286 1.1657754125864104 20.265605674332857 -10.460111160083388 5.311644377868761 0.9994316634248458 1.4190884233582344 0.4770909843490926 0.20682920719981016 0.0013938566070744232 0.00014167490891868348 0.20052333063490463 0.0667538395828435 3.466481125879002e-11 10.460111160083388 0.4196567599333886 AQLADSFHLQQFFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQLADSFHLQQFFR 14 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 11993200.0 5233800.0 2697000.0 4062400.0 False True 5067655.883837278 3773926.1646691957 2998335.570612327 1.0 0.744708451239894 0.5916612412802502 22.27288713177906 -11.109233912563745 0.07458544431286417 2.0186951102994666 2.8443886481274297e-13 0.9999593827464858 0.0010734585203279327 3.60685887171302 0.04712348105616763 1.0067754216120892 0.3818758232351305 7.776176105977589e-12 11.109233912563745 -2.0186951102991824 AQLADSFHLQQFFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQLADSFHLQQFFR 14 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 9244100.0 961500.0 2092100.0 6190500.0 False True 1316992.5335604977 1999664.1043504628 4728431.397349516 1.0 1.5183564472794375 3.5903251361389055 20.32881573585575 -6.9448907336778305 0.61237479997603 0.9771546731736088 4.239869361629824 0.9987368601685839 0.039773694107208386 0.08560456572568535 0.04496947005712557 0.040338666801213376 0.17486094558249882 1.1352964146498296e-07 6.9448907336778305 3.2627146884562155 AQLADSFHLQQFFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQLADSFHLQQFFR 14 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 10330800.0 5233800.0 2333300.0 2763700.0 False True 4352136.596653209 2320730.049776214 3341576.8920949786 1.0 0.5332392488693609 0.767801473571544 22.053292407213338 -10.248699245413869 4.807128724014999 1.0000854711042526 0.6505203612198267 0.7474637235032202 0.09575962724427815 8.774009872729293e-05 1.3712718477228216e-05 0.09274145162942768 0.030906286796028925 5.640281174292071e-11 10.248699245413869 -0.3495651098844259 AQLAHYNFQFVVGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQLAHYNFQFVVGQK 15 0 Q9BW92;U3KQG0;F6S7Q7;Q9BW92-2 Q9BW92 TARS2 Threonine--tRNA ligase, mitochondrial 0 43164000.0 13090000.0 12708000.0 17366000.0 False True 19858487.00718603 10440158.111942802 13933602.488211792 1.0 0.5257277711119134 0.7016447165974806 24.243252374168488 -10.051053212481044 5.0100299688848775 1.0000068028098013 0.613686243852288 0.8654085551103263 0.0718177922664641 5.45717694254632e-06 1.0337345341561322e-06 0.06953850269164263 0.023179092782920577 8.890921740399744e-11 10.051053212481044 -0.38632055895751327 AQLAK(ub)AEDGHAVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQLAKAEDGHAVAK 14 1 Q03252 Q03252 LMNB2 Lamin-B2 1 14572700.0 4324000.0 6718300.0 3530400.0 True False 5668805.873675562 5715955.8277282845 3165108.073988082 1.0 1.008317440234049 0.5583377071855659 22.43461343472761 -6.902689606170515 0.9441021368352851 1.0173530592107936 0.5084366786170469 0.987857713938996 0.023161206173044426 0.10945269792095223 0.16646223529946255 0.018302136834557486 0.048295224372513344 1.2511529200017843e-07 6.902689606170515 -0.5089163805937467 AQLAK(ub)AEDGHAVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQLAKAEDGHAVAK 14 1 Q03252 Q03252 LMNB2 Lamin-B2 1 19472000.0 9168500.0 6453300.0 3850200.0 True False 8877450.986083176 9030136.343514921 2841717.1164758727 1.0 1.0171992340674259 0.3201050753116766 23.081714059227707 -6.901243498244081 0.9533693508938906 1.0280020543823707 0.2450560174159965 0.9871749789058425 0.03676418071569406 0.1104958773644273 0.17230091765737385 0.028852846741623625 0.07554985193398547 1.2553259359426407e-07 6.901243498244081 -0.7829460369663742 down AQLAK(ub)AEDGHAVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQLAKAEDGHAVAK 14 1 Q03252 Q03252 LMNB2 Lamin-B2 1 13326600.0 9475100.0 0.0 3851500.0 True False 14374419.422596512 0.0 3090249.3368275804 1.0 0.0 0.21498254962351554 23.777000351534237 -10.062836488946346 4.582872122087665 1.0000372254790393 0.10749127493571713 0.9582992474653672 0.08776625861411373 157006798.8016303 362972681.17275447 110069.33615823323 0.032119163476056346 8.652936388790298e-11 10.062836488946346 -0.8925459505433222 AQLAK(ub)AEDGHAVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQLAKAEDGHAVAK 14 1 Q03252 Q03252 LMNB2 Lamin-B2 1 11538000.0 4324000.0 7214000.0 0.0 True False 5922699.65170628 6895261.626492151 0.0 1.0 1.1642092342983632 0.0 22.4978234962505 -6.930038627651558 1.2401396495138486 1.0877587740348975 2.1973400107403493e-21 0.9640867432502855 0.09750092217048185 0.11691874344177319 0.3591178031764569 0.06490358988215282 0.12553685963881045 1.174793060139261e-07 6.930038627651558 -1.0877587740348975 down AQLAK(ub)AEDGHAVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQLAKAEDGHAVAK 14 1 Q03252 Q03252 LMNB2 Lamin-B2 1 19370800.0 9168500.0 8502900.0 1699400.0 True False 7624013.983418353 8457093.190006502 2054736.6828621817 1.0 1.109270419545404 0.2695085144559122 22.862119334661983 -6.87417909531022 1.1118157997383078 1.0636659231546857 0.21627273404173847 0.9686759201481748 0.06597881798347022 0.13290781765931065 0.3045479020824305 0.0459300036050589 0.10959700388024987 1.336044441992605e-07 6.87417909531022 -0.8473931891129471 down AQLAK(ub)AEDGHAVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQLAKAEDGHAVAK 14 1 Q03252 Q03252 LMNB2 Lamin-B2 1 19980100.0 9475100.0 8623800.0 1881200.0 True False 12265703.73214378 8143877.949070538 1538840.9027420233 1.0 0.6639552142229319 0.1254588351673049 23.548126673626687 -7.416477809454267 0.521335362290247 1.0097574207502344 9.942969456828815e-23 0.99727679014122 0.018797058148196658 0.11082301208773974 0.06554543987323512 0.01999062477403518 0.06474838890295867 3.83285324100909e-08 7.416477809454267 -1.0097574207502344 down AQLDQTGQHLFCVCGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQLDQTGQHLFCVCGTR 17 0 Q12788 Q12788 TBL3 Transducin beta-like protein 3 0 9958300.0 2527300.0 4177900.0 3253100.0 False True 3313314.774408017 3554573.60532665 2916500.4179386552 1.0 1.0728149443518353 0.8802364449238724 21.659843839421413 -6.804298097990673 1.438651868243751 1.0399589619873906 0.8772983357984702 0.8443305200779256 0.03132519419422525 0.2146871695998817 0.8767914084977361 0.01712733646871604 0.03972590319243765 1.5692852834477938e-07 6.804298097990673 -0.1626606261889204 AQLDQTGQHLFCVCGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQLDQTGQHLFCVCGTR 17 0 Q12788 Q12788 TBL3 Transducin beta-like protein 3 0 7464000.0 2527300.0 2136800.0 2799900.0 False True 3461711.1077144537 2042389.1105473302 2138621.2857505693 1.0 0.5899940945377701 0.6177931142158665 21.723053900944304 -10.745280292204917 6.89072811905214 1.006959973357266 0.6038936043769744 0.996319597633047 0.011348902260154142 0.0012199135264110597 4.5094748744476385e-05 0.011046891999451119 0.003662842454276059 1.797710304428896e-11 10.745280292204917 -0.4030663689802917 AQLEEQLK(ub)EVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQLEEQLKEVR 11 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 10827800.0 4252100.0 3767600.0 2808100.0 True False 5574544.2773949765 3205488.765989778 2517544.749197243 1.0 0.5750225680309289 0.45161445024412095 22.41042243792379 -13.999999999999998 0.17337762642104537 3.162782143061361 0.34657836132285064 0.9995076408769058 0.005212022176590699 12.126171760872232 0.1319165550588553 8.823948372743576 0.09760114738432718 1.0000000000000041e-14 13.999999999999998 -2.81620378173851 AQLEEQLK(ub)EVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQLEEQLKEVR 11 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 10838100.0 4739800.0 2787000.0 3311300.0 True False 4589337.643435351 3899863.6340130004 2443971.193129333 1.0 0.849766118121951 0.5325324443332736 22.129854520896856 -6.958969052920941 0.44972788777678413 1.0102586217660634 0.35946954027557126 0.999730029766225 0.0032016927711098118 0.08007148163718304 0.02250773496514169 0.004238436070539697 0.02624152071822594 1.0990841554918508e-07 6.958969052920941 -0.6507890814904922 AQLEEQLK(ub)EVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQLEEQLKEVR 11 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 9634200.0 4252100.0 3926600.0 1455500.0 True False 5824216.278681844 3753109.82847021 1111740.876963447 1.0 0.6443974002489528 0.1908824850877722 22.47363249944668 -7.4354544978155355 0.4161355983715184 1.0309527585576421 2.6398051388738673e-12 0.9989426633672971 0.010767129183387817 0.1147391908904543 0.04572989849475003 0.016840359910250624 0.06268995218423067 3.6689813331794726e-08 7.4354544978155355 -1.0309527585550022 down AQLEEQLK(ub)EVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQLEEQLKEVR 11 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 10564600.0 4739800.0 3885400.0 1939400.0 True False 3941353.708742574 3864468.579008484 2344919.573227562 1.0 0.980492710013936 0.5949528376573112 21.910259796331133 -6.917404444298007 0.8437500090830553 1.0093282502059875 0.5363464372209037 0.993429077071072 0.015118992255191777 0.09972327488317771 0.11370455729593335 0.012850585092888375 0.0375884072493316 1.2094712677483793e-07 6.917404444298007 -0.4729818129850838 AQLEEQLK(ub)EVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQLEEQLKEVR 11 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 18961200.0 6454800.0 8630000.0 3876400.0 True False 8355865.843130051 8149732.913620307 3170934.9752228246 1.0 0.9753307516683959 0.3794861041037267 22.994357898851657 -6.91560653719397 0.856676908830077 1.0153413606901651 0.2924815228039103 0.9928708927656205 0.024222039609464677 0.10082647879736616 0.11951960558943374 0.0203979503419844 0.058755271840000886 1.2144886565540183e-07 6.91560653719397 -0.7228598378862547 down AQLGGPEAAK(ub)SDETAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQLGGPEAAKSDETAAK 17 1 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 1 77556940.0 26837570.0 29315400.0 21403970.0 True False 35184314.165397584 24941656.59053419 19189292.50577802 1.0 0.708885683355549 0.5453933936461364 25.06842905558952 -12.633324567554293 0.07763553002848493 2.338688612414386 6.146930624102859e-14 0.9999243140394696 0.0016356706950482543 7.5003152164813915 0.06459001257929724 2.0502596758592873 0.4344245912609662 2.3263520216576404e-13 12.633324567554293 -2.338688612414325 AQLGGPEAAK(ub)SDETAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQLGGPEAAKSDETAAK 17 1 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 1 98035000.0 28443100.0 33003300.0 36588600.0 True False 27540189.359465808 46181689.79993588 27004948.025528286 1.0 1.676883524552195 0.9805650815631173 24.715035143329406 -6.652592004767706 1.9989460972183342 1.4383145424200012 0.9834704693146461 0.20478830870471265 0.2887154281436592 0.5021927528203312 3.8491025223096123 0.11700879194536053 0.31990516737256036 2.225399546613439e-07 6.652592004767706 -0.45484407310535513 AQLGGPEAAK(ub)SDETAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQLGGPEAAKSDETAAK 17 1 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 1 462101100.0 74062500.0 93699600.0 294339000.0 True False 112358227.19401927 76978174.30168377 236162767.6366335 1.0 0.6851138205372223 2.101873387774529 26.74353052578359 -6.848394158382724 1.242885031947701 0.8321774636271607 2.1567597162971643 0.9379322998405633 0.15132559650925656 0.15922645976835353 0.4741443213079933 0.09531339816213238 0.2203374309866176 1.4177701931666343e-07 6.848394158382724 1.3245822526700035 up AQLGGPEAAK(ub)SDETAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQLGGPEAAKSDETAAK 17 1 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 1 80226270.0 26837570.0 23394900.0 29993800.0 True False 36760144.88705897 22361235.961411312 22909882.181701306 1.0 0.6083010834182907 0.6232261121953981 25.13163911711241 -9.77781789077218 6.267644957138041 1.0000000084022203 0.6157635978166957 0.9988696737292773 0.0060931174845073365 7.147769000549142e-10 1.402622944056245e-10 0.005899635767364367 0.0019665452118324414 1.667946472572818e-10 9.77781789077218 -0.3842364105855246 AQLGGPEAAK(ub)SDETAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQLGGPEAAKSDETAAK 17 1 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 1 104722700.0 28443100.0 48333400.0 27946200.0 True False 23651697.892977748 48073018.380771205 33789621.21137051 1.0 2.032539845481631 1.4286340610414587 24.495440418763682 -10.635015017973725 6.473352663544053 0.9968304660607078 1.7305869532615448 0.6611766533750592 0.2465435040989384 0.01130132183326874 0.0006371981509868173 0.23921498405834882 0.07957157379090073 2.317314515470618e-11 10.635015017973725 0.733756487200837 AQLGGPEAAK(ub)SDETAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQLGGPEAAKSDETAAK 17 1 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 1 686674900.0 74062500.0 96546400.0 516066000.0 True False 95875366.24013434 91173507.96889368 422147283.2843218 1.0 0.9509586408310123 4.403083918626085 26.51465684787604 -6.9036799225483145 0.9377252147704271 0.8706024367217222 4.793766941913196 0.9883094634465432 0.17471694154655718 0.10874655603129185 0.16254306339819782 0.13871591549461113 0.36805062398052446 1.2483031816978267e-07 6.9036799225483145 3.923164505191474 up AQLGGPEAAK(ub)SDETAAK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQLGGPEAAKSDETAAK 17 1 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 2 4166200.0 1122300.0 1362300.0 1681600.0 True False 1471346.168368661 1159050.1502038084 1507604.1630462173 1.0 0.7877481011072279 1.0246427356505483 20.48870528337758 -6.670525769967557 1.935539174399291 0.8645808801670007 1.0236865322175226 0.2813521865115828 0.09014923601728789 0.45991933122595663 3.32229904764655 0.037489629066290296 0.10009319038784195 2.1353753743596924e-07 6.670525769967557 0.15910565205052185 AQLGGPEAAK(ub)SDETAAK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQLGGPEAAKSDETAAK 17 1 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 2 5541400.0 1340100.0 2352600.0 1848700.0 True False 1297559.2590336525 3292005.44864693 1364470.0101888073 1.0 2.537075224678853 1.0515666245601654 20.30736899674104 -6.638203507218919 2.0506669321621955 2.006524248206941 1.0576962299289074 0.14779835306073075 0.6579650285044919 0.5379642819174116 4.321334388905404 0.26146957626046496 0.7287106058819943 2.3003636312344407e-07 6.638203507218919 -0.9488280182780335 AQLGGPEAAK(ub)SDETAAK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQLGGPEAAKSDETAAK 17 1 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 2 3858200.0 1122300.0 1108400.0 1627500.0 True False 1537244.6390171058 1059427.2230113528 1243118.0194146405 1.0 0.6891728200715904 0.8086663552845265 20.551915344900472 -10.061262447987001 5.5826559643868885 1.000001442659783 0.7489195879286363 0.8547936210309082 0.04878303147248328 8.75958242204047e-07 1.47321922185386e-07 0.04723423843270924 0.015744655705823687 8.684354674679373e-11 10.061262447987001 -0.25108185473114664 AQLGGPEAAK(ub)SDETAAK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQLGGPEAAKSDETAAK 17 1 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 2 6592100.0 1340100.0 3112000.0 2140000.0 True False 1114352.5264960371 3095235.038316362 2587464.1057579564 1.0 2.7776084898815627 2.3219439488273625 20.087774272175317 -10.179904627788451 5.1336309857419975 0.9999044651444243 2.549776219355598 0.9391120753548114 0.18602426991445561 65256699.856376834 13.479390409431602 73700.01554674233 0.06368105554661524 6.608385539603605e-11 10.179904627788451 1.549871754211174 AQLGGPEAAK(ub)SDETAAK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQLGGPEAAKSDETAAK 17 1 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 2 38097600.0 3276500.0 3573100.0 31248000.0 True False 4241493.839470726 3374253.8439926715 25561184.631555818 1.0 0.7955343027007029 6.02645803553624 22.016141035818475 -6.897803843872044 0.9750589319064586 0.7692190789044545 6.5516649769646484 0.9854413082133371 0.29189061806772104 0.113039535616943 0.18668213519864724 0.22541676202344035 0.5802860413444535 1.2653077151250358e-07 6.897803843872044 5.782445898060194 up AQLGGPEAAKSDETAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQLGGPEAAKSDETAAK 17 1 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 0 2536920.0 830440.0 912620.0 793860.0 False True 1088714.8819923997 776460.6533648972 711718.9824428344 1.0 0.7131900796138081 0.653723940229746 20.05419475277056 -13.999999999999998 0.2211610289128961 2.739596247520821 0.6222670916804125 0.9994990813235283 0.003383625697788119 13.031452585966548 0.14897159560644652 9.906636120885825 0.032659808174473226 1.0000000000000041e-14 13.999999999999998 -2.1173291558404084 AQLGGPEAAKSDETAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQLGGPEAAKSDETAAK 17 1 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 0 2226850.0 733060.0 989860.0 503930.0 False True 609571.8700643121 984527.4277081729 609299.4330909376 1.0 1.6151129605181775 0.9995530683308175 19.217436802702604 -6.646331932019804 2.021517662882062 1.400296952811963 1.0021292781502857 0.17935818982861473 0.262774533542021 0.5175770745934639 4.049794361409134 0.10557306858684266 0.2910373660907226 2.2577095393386606e-07 6.646331932019804 -0.39816767466167735 AQLGLGEIILAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQLGLGEIILAIR 13 0 Q6PID6 Q6PID6 TTC33 Tetratricopeptide repeat protein 33 0 3993800.0 0.0 2141000.0 1852800.0 False True 0.0 2021851.467909743 1515609.4113334161 0.0 AQLGLGHSYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQLGLGHSYSR 11 0 A0A494C128;O00567;Q5JXT2 A0A494C128 NOP56 Nucleolar protein 56 0 16547500.0 4318700.0 4963900.0 7264900.0 False True 5661857.522350295 4223305.469130652 6513197.837841604 1.0 0.7459222441502756 1.150364136174502 22.43284401436703 -6.7368899542939 1.6982105136817118 0.8482829755273206 1.1504386598350766 0.5908675855014771 0.10676302610753018 0.3234612838253867 1.8304104927982074 0.04976132180813899 0.12252315821725027 1.83277877062222e-07 6.7368899542939 0.3021556843077561 AQLGLGHSYSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQLGLGHSYSR 11 0 A0A494C128;O00567;Q5JXT2 A0A494C128 NOP56 Nucleolar protein 56 0 9190680.0 2104500.0 991480.0 6094700.0 False True 2037693.7994450608 1387383.1344998947 4498315.232919191 1.0 0.6808594769625006 2.2075521033357655 20.958505845945048 -6.852145111426064 1.224735737680377 0.8293352544955002 2.271141301475313 0.9433634765903183 0.15647601700033664 0.1551137349061555 0.44665837382198736 0.0999179072190811 0.23154947956584118 1.405577797972602e-07 6.852145111426064 1.4418060469798126 up AQLGLGHSYSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQLGLGHSYSR 11 0 A0A494C128;O00567;Q5JXT2 A0A494C128 NOP56 Nucleolar protein 56 0 11561100.0 4318700.0 3334400.0 3908000.0 False True 5915440.098479172 3187075.1826137304 2985010.887786435 1.0 0.5387722856720517 0.5046134925030963 22.496054075889923 -13.999999999999998 0.36932080536216866 7.397177432251778 0.5010344422498689 0.9997897359960212 0.003275755021591941 22.74055327656565 0.19719474014819052 115.13919181314931 0.009566912181764375 1.0000000000000041e-14 13.999999999999998 -6.896142990001909 AQLGLGHSYSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQLGLGHSYSR 11 0 A0A494C128;O00567;Q5JXT2 A0A494C128 NOP56 Nucleolar protein 56 0 6113800.0 2104500.0 2410700.0 1598600.0 False True 1749984.9951577599 2397713.0806135153 1932859.8689087215 1.0 1.3701335081432302 1.104500823868193 20.738911121379324 -10.14574897789013 4.565885251907458 0.9999701518799032 1.2373171660102453 0.515557009875944 0.1084440892620658 3.295376588629985e-05 6.165305026053068e-06 0.10501373288208984 0.035000179306707783 7.1490942416016e-11 10.14574897789013 0.2373470141303421 AQLHQLQLHAAVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQLHQLQLHAAVLR 14 0 Q13488;E9PNA6;E9PMC5;E9PM12 Q13488 TCIRG1 V-type proton ATPase 116 kDa subunit a isoform 3;V-type proton ATPase subunit a 0 8147500.0 2790900.0 3107700.0 2248900.0 False True 3658896.927114045 2644043.2737197247 2016205.4009720702 1.0 0.7226339867970027 0.5510418689389953 21.80297734416053 -9.563338584546972 0.09280324687185638 1.7354240211877885 8.471736322469116e-14 0.9999594969683174 0.0011771986386354908 1.0417214888502146 0.037518672903358675 0.44131450724726806 0.25571588999772404 2.7331370878809096e-10 9.563338584546972 -1.7354240211877037 AQLHQLQLHAAVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQLHQLQLHAAVLR 14 0 Q13488;E9PNA6;E9PMC5;E9PM12 Q13488 TCIRG1 V-type proton ATPase 116 kDa subunit a isoform 3;V-type proton ATPase subunit a 0 5599940.0 2118100.0 712140.0 2769700.0 False True 2050862.0748893223 996501.2157610407 2044232.4807810532 1.0 0.4858938238520103 0.996767411036831 20.96779903990152 -10.880578853659621 11.046162998839169 1.0124050802588718 0.7413306174457746 0.2547454893987169 0.20856326861134433 0.060732934342207626 0.0006565883388094028 0.1924849313736626 0.06731350549686006 1.3165008575649432e-11 10.880578853659621 -0.2710744628130972 AQLHQLQLHAAVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQLHQLQLHAAVLR 14 0 Q13488;E9PNA6;E9PMC5;E9PM12 Q13488 TCIRG1 V-type proton ATPase 116 kDa subunit a isoform 3;V-type proton ATPase subunit a 0 11775700.0 2790900.0 2457700.0 6527100.0 False True 3822771.1512366002 2349110.687472936 4985533.409844119 1.0 0.6145046602418351 1.3041673729884107 21.866187405683423 -6.75504333679858 1.6313706436678252 0.7747015040324944 1.306065687423074 0.670285073807591 0.16204463556581822 0.2913401772571273 1.526977707415114 0.0784216200046845 0.1893752267313417 1.7577482053733555e-07 6.75504333679858 0.5313641833905797 AQLHQLQLHAAVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQLHQLQLHAAVLR 14 0 Q13488;E9PNA6;E9PMC5;E9PM12 Q13488 TCIRG1 V-type proton ATPase 116 kDa subunit a isoform 3;V-type proton ATPase subunit a 0 21334000.0 2061600.0 7647400.0 11625000.0 False True 2668781.8402114585 7221815.467395118 9509369.28257284 1.0 2.7060344006323516 3.5631871962300874 21.34774994640059 -9.01469097339924 0.24890388026861449 2.0480075450694256e-17 4.15626449313976 0.9991655036591227 0.030776146592412054 0.4800541277626092 0.08479165721747042 0.7790452340554568 0.3616320648269356 9.66738526818359e-10 9.01469097339924 4.15626449313976 AQLLQPTLEINPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQLLQPTLEINPR 13 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 38332000.0 10826000.0 12744000.0 14762000.0 False True 14192990.83913313 10842644.875722932 13234569.847102888 1.0 0.7639436253159149 0.9324722320409262 23.7586752997076 -9.867338975705529 5.0828116237681416 1.0000002655501148 0.8482079288205562 0.5196135087623069 0.06880151560973392 93577154.97963235 58.83069617469553 290.8985841234816 0.023552588803196453 1.3572536688666245e-10 9.867338975705529 -0.1517923367295586 AQLLQPTLEINPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQLLQPTLEINPR 13 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 28562200.0 9030800.0 4423400.0 15108000.0 False True 8744122.19720999 6189686.687726262 11150761.56971521 1.0 0.7078682740391279 1.2752293847486615 23.05988213182496 -6.766712773449249 1.5867440198310796 0.8317461802160742 1.2780563032236347 0.7179878968328418 0.12302179036358503 0.27175087282490845 1.3497263399516863 0.06112741582229976 0.14596912693635333 1.711146630995122e-07 6.766712773449249 0.44631012300756057 AQLLQPTLEINPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQLLQPTLEINPR 13 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 44615000.0 10826000.0 14039000.0 19750000.0 False True 14828664.761649445 13418710.559235279 15085456.764017934 1.0 0.9049169817325258 1.0173172707385372 23.821885361230493 -6.68252474334785 1.893100596841714 0.939975318878034 1.0168960623085574 0.3355996828298494 0.040276627009377286 0.43295924773275296 3.002151265433957 0.017058838164624363 0.04484351881330743 2.0771853773396622e-07 6.68252474334785 0.07692074343052346 AQLLQPTLEINPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQLLQPTLEINPR 13 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 19211200.0 9030800.0 4102600.0 6077800.0 False True 7509510.332274017 4080498.479497658 7348639.879427894 1.0 0.5433774372692032 0.9785777706231069 22.840287407259236 -10.668360413205052 9.725432201982757 1.0001422657241275 0.760977603946155 0.2868328174988124 0.17766979210103448 0.0005483766115895947 1.8699770065921913e-05 0.1721286815806554 0.05734267882762008 2.1460487675290667e-11 10.668360413205052 -0.23916466177797246 AQLLQPTLEINPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQLLQPTLEINPR 13 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 13273400.0 2876600.0 6304600.0 4092200.0 False True 3723815.4062632364 5953743.467811195 3347461.589517816 1.0 1.5988288403870268 0.8989332779190892 21.82835012797029 -6.680148721102189 1.9011507774900516 1.3788286779010932 0.9015801041143321 0.32490821638995226 0.2537884480378157 0.43818615454362647 3.062134678886692 0.1071052268468889 0.28245058447016397 2.088580788522883e-07 6.680148721102189 -0.4772485737867611 AQLSDYSDIVTTLDLAPPTKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQLSDYSDIVTTLDLAPPTKK 21 1 O60216 O60216 RAD21 Double-strand-break repair protein rad21 homolog 1 58538100.0 8072100.0 14793000.0 35673000.0 True False 12245965.84955738 12153073.57176346 28622215.913968667 1.0 0.9924144588564832 2.337277129921377 23.54580322916405 -6.905630627512299 0.9249880170920293 0.9523908344016285 2.4957592319752546 0.9891653048474394 0.06580497300886495 0.10737844450435544 0.15496940047162308 0.05273757210023763 0.14152605949949934 1.2427087964775778e-07 6.905630627512299 1.543368397573626 up AQLVEIVGCHFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQLVEIVGCHFR 12 0 O75446 O75446 SAP30 Histone deacetylase complex subunit SAP30 0 5431300.0 1441500.0 1660000.0 2329800.0 False True 1889820.4595058563 1412334.47062932 2088734.645019668 1.0 0.7473379090194697 1.1052555995535274 20.849817748487865 -6.7170040792062995 1.7698359625258546 0.8457989677794484 1.1046168094530202 0.4985024851599299 0.10636154356985124 0.36114968363624833 2.2090854466320886 0.04774582651412318 0.12029606326516273 1.9186507192374067e-07 6.7170040792062995 0.2588178416735718 AQLVEIVGCHFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQLVEIVGCHFR 12 0 O75446 O75446 SAP30 Histone deacetylase complex subunit SAP30 0 5180900.0 1441500.0 1375100.0 2364300.0 False True 1974461.5050727571 1314343.5351523908 1805901.034286967 1.0 0.6656718967554439 0.9146296494751976 20.913027810010757 -10.286643115053808 5.442981381336048 1.0000274864802638 0.790150773115312 0.4864768618317683 0.10163657694559529 3.390507778213691e-05 4.4437876476793555e-06 0.0984220703043708 0.032803064156313844 5.1684091294483335e-11 10.286643115053808 -0.20987671336495184 AQNDLIWNIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQNDLIWNIK 10 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 12863700.0 0.0 4968500.0 7895200.0 False True 0.0 4227219.167061312 7078280.440106135 0.0 AQNDLIWNIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQNDLIWNIK 10 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 4492600.0 0.0 0.0 4492600.0 False True 0.0 0.0 3431540.408001366 0.0 AQNDLIWNIK(ub)DELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQNDLIWNIKDELK 14 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 16923300.0 3369500.0 5102900.0 8450900.0 True False 3262537.066871054 7140514.581271963 6237355.768434357 1.0 2.188638606984501 1.9118114646943496 21.637562862083254 -10.052288303675285 4.612513918800251 0.9999569688234263 2.050225035664405 0.9504717390781658 0.11301420774443828 39148017.254167385 2.207572849007106 18569.99028034175 0.038687769290065635 8.865672745050454e-11 10.052288303675285 1.0502680668409785 AQNDLIWNIK(ub)DELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQNDLIWNIKDELK 14 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 19617000.0 4159700.0 4331300.0 11126000.0 True False 6310569.014804552 3558345.67439864 8926941.223300962 1.0 0.5638708119744488 1.4146016313835437 22.58933866610494 -6.767341306320395 1.5846392928975195 0.749009283197999 1.4189160500122877 0.7203447760552775 0.18368527928138034 0.27071851765185384 1.3411865498616398 0.09139147508349867 0.21808383181070426 1.7086719644785058e-07 6.767341306320395 0.6699067668142887 AQNDLIWNIK(ub)DELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQNDLIWNIKDELK 14 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 15274600.0 3369500.0 6454800.0 5450300.0 True False 2801888.5441596922 6420026.711222511 6589932.530660086 1.0 2.2913212321041576 2.3519609816015925 21.41796813751753 -10.769401600196636 0.5596853556058283 1.968431363934783e-23 2.3464132714842236 0.9998313560081346 0.008097205966752454 2.3656713896703674 0.2722972895274573 3.2008000400486663 0.011148585186913052 1.7005852182550933e-11 10.769401600196636 2.3464132714842236 AQNKPFYVVAESFKFVRLFPLNQQDVPDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQNKPFYVVAESFKFVRLFPLNQQDVPDK 29 3 Q14232 Q14232 EIF2B1 Translation initiation factor eIF-2B subunit alpha 0 21746900.0 6185800.0 5260100.0 10301000.0 False True 5989435.164935734 7360485.361059128 7602859.076624051 1.0 1.2289114346123997 1.2693783081806895 22.513988525064633 -13.131216304989474 0.25572144602747093 5.091876891769967e-07 1.285266211666133 0.9994997063982293 0.0026528436264646803 9.206245104714002 0.15624220297139746 4.718618222197606 0.01810526033813896 7.39236998498056e-14 13.131216304989474 1.285265702478444 AQNKPFYVVAESFKFVRLFPLNQQDVPDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQNKPFYVVAESFKFVRLFPLNQQDVPDK 29 3 Q14232 Q14232 EIF2B1 Translation initiation factor eIF-2B subunit alpha 0 19379700.0 6185800.0 6301700.0 6892200.0 False True 5143766.777404071 6267751.491310482 8333327.154067751 1.0 1.218513933960602 1.6200826193510607 22.29439380049891 -6.961665352262395 0.41129046884135034 0.9804946436289089 1.8730359031436612 0.9998270640989618 0.003377023277536039 0.07911150292398131 0.018972132219774493 0.005172908380614408 0.033514110919509024 1.0922816752465815e-07 6.961665352262395 0.8925412595147523 AQPAQPADEPAEK(ub)ADEPMEH ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQPAQPADEPAEKADEPMEH 20 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 31536700.0 6900700.0 12588000.0 12048000.0 True False 9046884.526473865 10709919.467639675 10801388.532576611 1.0 1.1838240486323526 1.1939346082033597 23.108989626488746 -12.649131085048884 0.4316875824294813 1.0514244570897905e-07 1.1941458329697956 0.9998456541452322 0.001107352554437256 9.822224224242987 0.219070897128261 8.945376523091005 0.0023829864545122127 2.2432047450533841e-13 12.649131085048884 1.19414572782735 AQPAQPADEPAEK(ub)ADEPMEH ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQPAQPADEPAEKADEPMEH 20 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 48890200.0 7891200.0 16539000.0 24460000.0 True False 7640698.1754244985 23143108.949745603 18053192.21572902 1.0 3.028925946084741 2.3627673546633754 22.86527304111947 -10.123460475509022 5.348470167024319 0.9999652270864456 2.695846650374926 0.8962747402032191 0.27195810612862875 0.00011276699678348262 1.8482408218768454e-05 0.26332765366265903 0.08777410132475129 7.525572161633505e-11 10.123460475509022 1.6958814232884802 AQPAQPADEPAEK(ub)ADEPMEH ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQPAQPADEPAEKADEPMEH 20 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 91789000.0 13587000.0 59395000.0 18807000.0 True False 20612472.34275296 48795498.19474683 15089788.206599085 1.0 2.3672802264257546 0.7320707557870626 24.29701422210715 -6.684860141911569 1.884539885203072 1.8612918673487038 0.7380309118299246 0.34651618495838243 0.5788807865350719 0.42782932829735043 2.9416656409723014 0.24610229224239372 0.6450836918700265 2.0660453879262075e-07 6.684860141911569 -1.1232609555187791 AQPAQPADEPAEK(ub)ADEPMEH ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQPAQPADEPAEKADEPMEH 20 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 34971600.0 6900700.0 8803900.0 19267000.0 True False 9452075.274405543 8414914.587395925 14716531.41632067 1.0 0.8902716433270421 1.5569629937427913 23.172199688011638 -6.864644658555153 1.1619719778050925 0.9395521196720835 1.5922437056827705 0.9590441775097348 0.059068576861405785 0.1420974435220424 0.3619543410625181 0.0395653568789251 0.09290048525200183 1.3657001007419328e-07 6.864644658555153 0.652691586010687 AQPAQPADEPAEK(ub)ADEPMEH ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQPAQPADEPAEKADEPMEH 20 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 47409200.0 7891200.0 28586000.0 10932000.0 True False 6561882.439434027 28432001.544123232 13217830.656142978 1.0 4.332903218939037 2.0143351817322466 22.645678316553745 -6.551190336624645 2.3821145151891776 3.3073903656424637 2.0169539078861765 0.0 1.4583742520256524 0.7901251436901127 8.392367171207004 0.523994824152252 1.646541933589742 2.810668739109327e-07 6.551190336624645 -1.2904364577562872 AQPSVSLGAAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQPSVSLGAAYR 12 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 54772000.0 16107000.0 12793000.0 25872000.0 False True 21116432.980409898 10884334.26672342 23195013.621748127 1.0 0.5154437909480742 1.0984342688590714 24.331862817274654 -6.686108699159329 1.8805171866808925 0.6951048434021236 1.096314003278833 0.3521288972070902 0.2050992179838831 0.4251011044912294 2.9115662308210313 0.0873566666863563 0.2285819040937815 2.060114224676282e-07 6.686108699159329 0.40120915987670935 AQPSVSLGAAYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQPSVSLGAAYR 12 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 35085500.0 11414000.0 4203500.0 19468000.0 False True 11051668.817707725 5881979.470962909 14368746.7725189 1.0 0.532225455538299 1.3001427213866859 23.397760899280442 -6.741844106964302 1.6800899061955474 0.7222718409226973 1.3007641616168093 0.6131478245911317 0.1965320625127503 0.31448153237060233 1.743696737161714 0.09251732661238354 0.22655849068613296 1.8119904024988363e-07 6.741844106964302 0.578492320694112 AQPSVSLGAAYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQPSVSLGAAYR 12 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 42106400.0 7018400.0 23800000.0 11288000.0 False True 10647425.913768843 19552704.049751278 9056921.852293845 1.0 1.8363785020064305 0.8506207909445777 23.344001355667277 -6.681920797244924 1.8954723239571378 1.5282800492558095 0.854350594848574 0.3327973113211793 0.3543301547655117 0.4342455865549414 3.018169456446384 0.14992249224290505 0.39438092043122597 2.0800759982278096e-07 6.681920797244924 -0.6739294544072355 AQPSVSLGAAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQPSVSLGAAYR 12 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 36346700.0 16107000.0 9619700.0 10620000.0 False True 22062193.175308317 9194669.845906088 8111774.725765579 1.0 0.41676136968089955 0.3676776221343288 24.395072878797546 -13.999999999999998 0.35060103101330237 8.199169536221927 0.36095014877721354 0.9997558526752638 0.004487719693895769 20.720002983571277 0.19065173305966188 111.12430715901176 0.014614903221992142 1.0000000000000041e-14 13.999999999999998 -7.838219387444713 AQPSVSLGAAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQPSVSLGAAYR 12 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 22610800.0 11414000.0 7126400.0 4070400.0 False True 9491246.725935213 7088008.668720344 4921501.820596808 1.0 0.7467942698562535 0.5185305958961751 23.17816617471472 -6.972356960984597 0.1937903906129491 1.1472470232492769 0.11181721687103892 0.999995403419319 0.00042156442107555044 0.07554504350256626 0.0062102038431438925 0.007804007082448737 0.02462771733663745 1.0657198108194164e-07 6.972356960984597 -1.035429806378238 AQPSVSLGAAYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQPSVSLGAAYR 12 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 33811700.0 7018400.0 18585000.0 8208300.0 False True 9085457.153346956 17550728.412472006 6714473.624270344 1.0 1.9317386143862405 0.7390353078487444 23.115127677759727 -6.698295983008431 1.8371646165934903 1.5795383766044333 0.7427183768166209 0.4094281268277441 0.3934222319582057 0.3990598477549242 2.617408067658233 0.1709281782360412 0.4404735134441536 2.0031063928465893e-07 6.698295983008431 -0.8368199997878124 AQPWLFDAPK(ub)FR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQPWLFDAPKFR 12 1 F5H1N0;G3V1M6;J3KQJ3;Q9BRQ3-2;Q9BRQ3-3;Q9BRQ3 F5H1N0 NUDT22 Nucleoside diphosphate-linked moiety X motif 22 1 52671000.0 13911000.0 20179000.0 18581000.0 True False 18237455.71431564 17168371.85712594 16658416.361537648 1.0 0.9413797695283497 0.9134177827481432 24.120401139088642 -13.999999999998838 0.09816084479540703 1.291128405791942 0.852126523562886 0.9998028702796254 0.0005065145092675386 12.094682573277163 0.09292754444424196 0.7167187184896074 0.054724364065647374 1.000000000002675e-14 13.999999999998838 -0.4390018822290561 AQPWLFDAPK(ub)FR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQPWLFDAPKFR 12 1 F5H1N0;G3V1M6;J3KQJ3;Q9BRQ3-2;Q9BRQ3-3;Q9BRQ3 F5H1N0 NUDT22 Nucleoside diphosphate-linked moiety X motif 22 1 77583000.0 24779000.0 23585000.0 29219000.0 True False 23992404.20833888 33002613.494150233 21565667.348789275 1.0 1.3755442434018237 0.8988539523393758 24.516074397318327 -6.696651224005826 1.8424480757359645 1.2339644250598634 0.9003446824438228 0.4017139396549869 0.15862249348504223 0.4026133615163466 2.6545989164031507 0.06873926685659973 0.1775376086131801 2.0107069357863154e-07 6.696651224005826 -0.33361974261604055 AQPWLFDAPK(ub)FR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQPWLFDAPKFR 12 1 F5H1N0;G3V1M6;J3KQJ3;Q9BRQ3-2;Q9BRQ3-3;Q9BRQ3 F5H1N0 NUDT22 Nucleoside diphosphate-linked moiety X motif 22 1 115164000.0 35489000.0 30899000.0 48776000.0 True False 53839407.593431965 25384832.035011098 39135402.22071974 1.0 0.4714916669719797 0.7268913973989192 25.682159199963632 -10.093956858747282 5.166647194739228 1.0000083508667494 0.5991915321847395 0.766560314660441 0.10426650333421338 1.0029896656891094e-05 1.7587203226204633e-06 0.10095770983510051 0.03365186924803356 8.054584485721605e-11 10.093956858747282 -0.4008168186820099 AQPWLFDAPK(ub)FR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQPWLFDAPKFR 12 1 F5H1N0;G3V1M6;J3KQJ3;Q9BRQ3-2;Q9BRQ3-3;Q9BRQ3 F5H1N0 NUDT22 Nucleoside diphosphate-linked moiety X motif 22 1 57740000.0 13911000.0 20388000.0 23441000.0 True False 19054272.63063972 19487190.7458999 17904718.582549058 1.0 1.0227202645649165 0.9396694867143786 24.183611200611534 -6.8337836984296345 1.310783869680947 1.0121125942726859 0.937254769232057 0.9132508442691376 0.010321896724765302 0.17619165111265642 0.590677406832961 0.006179991128051328 0.014223658602644525 1.466277942919448e-07 6.8337836984296345 -0.07485782504062888 AQPWLFDAPK(ub)FR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQPWLFDAPKFR 12 1 F5H1N0;G3V1M6;J3KQJ3;Q9BRQ3-2;Q9BRQ3-3;Q9BRQ3 F5H1N0 NUDT22 Nucleoside diphosphate-linked moiety X motif 22 1 64857000.0 24779000.0 24947000.0 15131000.0 True False 20604836.395825204 24812605.55940822 18294822.142160587 1.0 1.2042126946679161 0.8878897066063259 24.296479672752604 -6.732434822165373 1.7145550692688203 1.1225635586187854 0.8880007038479223 0.5703877010300553 0.08583111882591882 0.33171290107588725 1.9115003885618533 0.03965469788955955 0.09812275039929298 1.851676768392895e-07 6.732434822165373 -0.23456285477086314 AQPWLFDAPK(ub)FR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQPWLFDAPKFR 12 1 F5H1N0;G3V1M6;J3KQJ3;Q9BRQ3-2;Q9BRQ3-3;Q9BRQ3 F5H1N0 NUDT22 Nucleoside diphosphate-linked moiety X motif 22 1 84566000.0 35489000.0 29655000.0 19422000.0 True False 45941210.09277478 28004673.181159943 15887395.286548788 1.0 0.609576306862763 0.34582013086867763 25.45328552205608 -8.223743686822642 0.192668111358011 1.291313596351343 4.5689781896981646e-07 0.9998123648392981 0.0036810783139190305 0.0867780376665103 0.040353699845774645 0.10935886123582828 0.11691052396889048 5.973877506003519e-09 8.223743686822642 -1.291313139453524 down AQQDK(ub)VMETSAQSSGDHQEQHVSVQEMQELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQQDKVMETSAQSSGDHQEQHVSVQEMQELK 31 1 P12270 P12270 TPR Nucleoprotein TPR 1 8969500.0 3122500.0 4050100.0 1796900.0 True False 2596497.1002043705 4028281.3074180954 2172623.4820731184 1.0 1.5514291570366203 0.8367517459973712 21.308135183533587 -6.70063029411775 1.8284252897664255 1.3421980791803656 0.8388379174053119 0.42066745250308035 0.23273765253818385 0.39420838304640066 2.5625655218778145 0.10152699083527145 0.26091671909534403 1.9923686794023666e-07 6.70063029411775 -0.5033601617750537 AQQDK(ub)VMETSAQSSGDHQEQHVSVQEMQELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQQDKVMETSAQSSGDHQEQHVSVQEMQELK 31 1 P12270 P12270 TPR Nucleoprotein TPR 1 62084700.0 4858700.0 20581000.0 36645000.0 True False 6289682.929295416 19435649.25784698 29975986.00945223 1.0 3.0900841069939604 4.765897795870325 22.584555860218423 -7.635426730173788 0.22506589823530285 1.7585754343287197e-14 6.777848606248377 0.9998683520880278 0.017675594329294688 0.1369467317447653 0.02769139629323619 0.23490141166325082 0.45966404853273946 2.3151187367737167e-08 7.635426730173788 6.77784860624836 AQQDQLVLIFAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQQDQLVLIFAGK 13 0 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 0 5842800.0 1338400.0 2224900.0 2279500.0 False True 1754655.3610840363 1892953.5925922724 2043639.206507997 1.0 1.0788178890142819 1.1646955019391527 20.74275626214395 -6.970026462024619 0.2575542604127141 0.9751583344838823 1.2708948183012632 0.9999825808133422 0.0002806474682256456 0.0762941884845196 0.008999468691636368 0.001821437209397546 0.008132777914625714 1.0714540184158824e-07 6.970026462024619 0.2957364838173808 AQQDQLVLIFAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQQDQLVLIFAGK 13 0 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 0 7785200.0 2536600.0 2116700.0 3131900.0 False True 2456077.021464642 2961909.3484446756 2311561.4350139694 1.0 1.2059513291152362 0.9411599940931441 21.2279243730057 -6.699106227734575 1.8338678716274162 1.1279984687089675 0.9419560850187976 0.4134024565280384 0.08694886314490341 0.39739571854363087 2.59762007709999 0.037832341176961215 0.09740910504659658 1.9993727664423888e-07 6.699106227734575 -0.1860423836901699 AQQDQLVLIFAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQQDQLVLIFAGK 13 0 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 0 7329200.0 1338400.0 1974300.0 4016500.0 False True 1833242.6489000197 1887068.8978629692 3067885.422414074 1.0 1.0293612244921566 1.6734748257438061 20.80596632366684 -6.91642996043781 0.8507772560115306 0.9838787452566616 1.7692709957911792 0.993130564363421 0.025758898595928673 0.10031818113942957 0.11683321092444887 0.021784152525027165 0.0631845460104082 1.2121881650846394e-07 6.91642996043781 0.7853922505345176 AQQDQLVLIFAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQQDQLVLIFAGK 13 0 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 0 4629000.0 2536600.0 1097100.0 995300.0 False True 2109295.290433439 1091189.7045426995 1203412.6282527545 1.0 0.5173242975944212 0.570528286727206 21.008329648439975 -10.455762513699918 5.155368358537647 1.0007133297219857 0.5439262921608019 0.9898965562726851 0.021720437609358087 0.00017834773825279877 1.882768172943981e-05 0.021062092380053615 0.007010241094442568 3.5013658071977227e-11 10.455762513699918 -0.4567870375611838 AQQEFATGVMSNK(ub)TVQTAAANAASTAASSAAQNAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQQEFATGVMSNKTVQTAAANAASTAASSAAQNAFK 36 1 A0A087WXB0;O15126;A0A087WU14 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 22069800.0 11164000.0 4302300.0 6603500.0 True False 10809604.930864638 6020230.826198116 4873845.249246376 1.0 0.556933473952278 0.450880978575831 23.36581046067006 -13.999999999999998 0.20084175967470533 3.470868741707668 0.3825740817330134 0.9994869847311773 0.005386907898970957 12.547665135881179 0.14209876076359018 12.183549260976676 0.06710730244599114 1.0000000000000041e-14 13.999999999999998 -3.088294659974655 AQQEFATGVMSNK(ub)TVQTAAANAASTAASSAAQNAFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQQEFATGVMSNKTVQTAAANAASTAASSAAQNAFK 36 1 A0A087WXB0;O15126;A0A087WU14 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 55005000.0 24847000.0 16900000.0 13258000.0 True False 37694715.55901839 13884062.959697334 10637550.488812178 1.0 0.3683291610984341 0.28220269953110616 25.167858949743465 -13.999999999999998 0.2807702527215684 6.169964243117854 0.2564711155482162 0.9996068835877352 0.006344892025207053 15.44004838019087 0.16786563543964655 45.857152112502135 0.03394519399001968 1.0000000000000041e-14 13.999999999999998 -5.913493127569637 AQQEFATGVMSNK(ub)TVQTAAANAASTAASSAAQNAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQQEFATGVMSNKTVQTAAANAASTAASSAAQNAFK 36 1 A0A087WXB0;O15126;A0A087WU14 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 6204200.0 1938300.0 1490600.0 2775300.0 True False 2654941.890587948 1424740.3632449682 2119831.2990976693 1.0 0.5366371174811113 0.7984473432780949 21.340248854053023 -10.159080599193324 5.466253255044682 1.000008415076629 0.6675422303795427 0.6825397019430884 0.10688357710779058 1.0961490843769744e-05 1.6862898310723302e-06 0.10349219744297537 0.03449652617676476 6.932971274883577e-11 10.159080599193324 -0.33246618469708633 AQQEFATGVMSNK(ub)TVQTAAANAASTAASSAAQNAFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQQEFATGVMSNKTVQTAAANAASTAASSAAQNAFK 36 1 A0A087WXB0;O15126;A0A087WU14 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 44298400.0 24847000.0 10266000.0 9185400.0 True False 32164931.30759318 9694688.07546074 7513751.450162972 1.0 0.30140552711742036 0.2336007305070538 24.938985271835914 -13.999999999999998 0.3298149695055677 8.596194468769015 0.22156652062519372 0.9997144578545346 0.005853632242839579 18.807542110286686 0.18363391716679514 99.09166245968964 0.021743175510773757 1.0000000000000041e-14 13.999999999999998 -8.374627948143821 AQQHWGSGVGVK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQQHWGSGVGVKK 13 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7;C9IZD2 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 8145320.0 844420.0 1476500.0 5824400.0 True False 817614.3493121389 2066074.1498457827 4298814.911745375 1.0 2.5269543661800657 5.257753750728543 19.641060990550656 -6.962171406662392 0.40366666316140604 0.8558227148291131 7.029190797435401 0.999842448771293 0.022106831699877504 0.07893437711084587 0.018330895384076843 0.03513061945769858 0.22849135586164682 1.0910096534912867e-07 6.962171406662392 6.173368082606288 AQQHWGSGVGVK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQQHWGSGVGVKK 13 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7;C9IZD2 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 23200070.0 921970.0 3001100.0 19277000.0 True False 1398695.8950355465 2465530.2572986786 15466892.500590758 1.0 1.7627350348633286 11.058080999227986 20.415650894646593 -6.923173492233952 0.8008519559229089 0.8173969248935683 12.672127963919316 0.9950176720152095 0.3227358878632079 0.09634058297330525 0.09620543023998282 0.28284838108015703 0.8747523744521295 1.193511224600599e-07 6.923173492233952 11.854731039025747 up AQQNNVEHK(ub)VETFSGVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQQNNVEHKVETFSGVYK 18 1 P62081;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 29094000.0 8850200.0 11211000.0 9032800.0 True False 8569255.245354557 15687610.76459266 6666838.701808541 1.0 1.8306854347811619 0.7779951128684925 23.03073839437108 -6.6963368939853956 1.84397012634193 1.5176592437810528 0.7813348782327212 0.4002290913945451 0.35088231375983986 0.40317383924815303 2.6625581755286443 0.1519582220401687 0.39256783566277004 2.01216275517804e-07 6.6963368939853956 -0.7363243655483316 AQQQEEQGSVNDVK(ub)EEEKEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQQQEEQGSVNDVKEEEKEEK 21 2 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 4785000.0 1478600.0 1830600.0 1475800.0 True False 1938458.9187827695 1557481.61562291 1323098.3728732208 1.0 0.8034638240365242 0.6825516703258502 20.886478730105097 -12.375117388480806 0.05365690276462836 2.1850264451218737 7.58383163932638e-12 0.999980405809782 0.0005790404427713698 6.867587403999439 0.044286171417422915 1.4734714874409756 0.535936836227994 4.2158253554641574e-13 12.375117388480806 -2.18502644511429 AQQQEEQGSVNDVK(ub)EEEKEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQQQEEQGSVNDVKEEEKEEK 21 2 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 7602900.0 1871300.0 1789700.0 3941900.0 True False 1811896.6057978321 2504336.543162207 2909398.1355348397 1.0 1.3821630523224437 1.6057197338000118 20.78906920100045 -10.17095791343563 0.10070021622111767 5.855494619807638e-15 2.2128593997726616 0.9999207047624838 0.0022270254214419843 1.8772543344659536 0.05006275759714439 0.8081145067380082 0.3382234425300278 6.745933979570945e-11 10.17095791343563 2.2128593997726558 AQQQEEQGSVNDVK(ub)EEEKEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQQQEEQGSVNDVKEEEKEEK 21 2 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 4460700.0 1478600.0 1197600.0 1784500.0 True False 2025278.3776625611 1144686.0720663986 1363037.8529311374 1.0 0.5651993744126759 0.6730125932141058 20.949688791627988 -9.964409280416957 6.90865561944595 1.0000000266848332 0.6191059838133981 0.9433167748236548 0.04401456226509435 1.8067734393829426e-08 2.7575912821093446e-09 0.04261691920098654 0.014205638886942706 1.0854022551527695e-10 9.964409280416957 -0.38089404287143513 AQTEGINISEEALNHLGEIGTK(ub)TTLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQTEGINISEEALNHLGEIGTKTTLR 26 1 Q9Y265;H7C4G5;J3QLR1 Q9Y265 RUVBL1 RuvB-like 1 1 82540800.0 44809800.0 14023000.0 23708000.0 True False 67979742.63518742 11520486.087800905 19022103.40841447 1.0 0.16946939840042458 0.27982017393764474 26.018601564195833 -10.725559785281849 6.954120103046194 1.0095721720798592 0.22464478616903466 0.9850354898671732 0.04505051546443161 0.0066128137238331275 0.0002609705191483409 0.043143698722647714 0.014539991344316943 1.8812227179586272e-11 10.725559785281849 -0.7849273859108246 AQTEGINISEEALNHLGEIGTK(ub)TTLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQTEGINISEEALNHLGEIGTKTTLR 26 1 Q9Y265;H7C4G5;J3QLR1 Q9Y265 RUVBL1 RuvB-like 1 1 85446800.0 44809800.0 21336000.0 19301000.0 True False 58007169.4332108 20148632.844148643 15788416.044983938 1.0 0.34734728553420785 0.2721804252690291 25.789727886288283 -13.999999999999998 0.30503743391676824 7.128996810653771 0.25463327818262294 0.9996610378474681 0.0060171343712510095 16.924115387761542 0.17555954149876518 65.65513155321989 0.0265897094228041 1.0000000000000041e-14 13.999999999999998 -6.874363532471148 AQTEGNEDSEGK(ub)EQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQTEGNEDSEGKEQR 15 1 Q9NQZ5;C9JTD3 Q9NQZ5 STARD7 StAR-related lipid transfer protein 7, mitochondrial 1 25390800.0 5761900.0 4735900.0 14893000.0 True False 7553906.698318973 4029322.1803936157 13352015.223743616 1.0 0.5334090479685553 1.7675642229887403 22.848791533840437 -6.804283153221992 1.4384794938097547 0.7439433666364808 1.786434942594352 0.8443596775869777 0.2007325746319444 0.21470085839004546 0.8766027331595085 0.10976033215604646 0.2546121346550224 1.5693392859968876e-07 6.804283153221992 1.0424915759578712 AQTEGNEDSEGK(ub)EQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQTEGNEDSEGKEQR 15 1 Q9NQZ5;C9JTD3 Q9NQZ5 STARD7 StAR-related lipid transfer protein 7, mitochondrial 1 15115600.0 3674500.0 4148600.0 7292500.0 True False 3557855.0088196136 5805157.614663193 5382375.479689436 1.0 1.6316453594294067 1.5128147342561724 21.76257628782157 -10.135611052753326 4.390060329694648 0.9999092108589567 1.5722300468717685 0.9686705468809254 0.04851239968367101 33887886.24710932 5.8327700063129235 31447.137316423024 0.01660708475075894 7.317941733452387e-11 10.135611052753326 0.5723208360128118 AQTEGNEDSEGK(ub)EQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQTEGNEDSEGKEQR 15 1 Q9NQZ5;C9JTD3 Q9NQZ5 STARD7 StAR-related lipid transfer protein 7, mitochondrial 1 7774700.0 3674500.0 4100200.0 0.0 True False 3055509.557950672 4078111.4087740206 0.0 1.0 1.3346747347467656 0.0 21.542981563255847 -6.8735605688454955 1.3537569128669324 1.1752806610053033 3.749006622666513e-20 0.9238959194927805 0.156417103798612 0.1539625401061287 0.5672982868716399 0.09354514316728618 0.19205943159038205 1.3379486052453723e-07 6.8735605688454955 -1.1752806610053033 down AQTGAPCLSFDIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQTGAPCLSFDIVR 14 0 Q9BQ67 Q9BQ67 GRWD1 Glutamate-rich WD repeat-containing protein 1 0 17064100.0 4690700.0 5473600.0 6899800.0 False True 6149553.124803417 4656960.215925692 6185874.883555121 1.0 0.7572843296763228 1.0059064062078273 22.552050145946115 -11.039204169404705 10.300282506521736 1.3000424568036875 0.8815953679420557 0.23219287106621322 0.10149953771556247 0.04920840519047999 0.00018729352697355306 0.0069149991340949355 0.03275883493501043 9.136836019029629e-12 11.039204169404705 -0.41844708886163173 AQTGAPCLSFDIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQTGAPCLSFDIVR 14 0 Q9BQ67 Q9BQ67 GRWD1 Glutamate-rich WD repeat-containing protein 1 0 4394300.0 2901100.0 0.0 1493200.0 False True 2809006.168481856 0.0 1102086.1249602018 1.0 0.0 0.3923402295537965 21.421628361901128 -10.687240527310728 6.663457925930339 1.0066237595913479 0.19617011477690685 0.8484118134407648 0.16017222799553701 0.015728471177275206 0.0007382387575195495 0.15476262027279847 0.051695364295970984 2.0547522878842866e-11 10.687240527310728 -0.810453644814441 AQTGAPCLSFDIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQTGAPCLSFDIVR 14 0 Q9BQ67 Q9BQ67 GRWD1 Glutamate-rich WD repeat-containing protein 1 0 25985200.0 2739600.0 15818000.0 7427600.0 False True 4156173.491587992 12995154.313401893 5959531.604367271 1.0 3.126711226012055 1.4338986609748698 21.98682444739438 -6.589149223191529 2.2319910723526593 2.4401439705742862 1.4387389834543958 0.0 0.9217691040400556 0.6720267776164712 6.310283103502708 0.3449202227890043 1.0277026412970673 2.575436087444395e-07 6.589149223191529 -1.0014049871198905 AQTGAPCLSFDIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQTGAPCLSFDIVR 14 0 Q9BQ67 Q9BQ67 GRWD1 Glutamate-rich WD repeat-containing protein 1 0 16727700.0 4690700.0 6577900.0 5459100.0 False True 6424978.551401171 6287266.627793556 4169773.013693684 1.0 0.9785661660181602 0.6489940752851746 22.615260207469007 -6.920126961932622 0.8237990705034367 1.0072386562805715 0.5956946625200221 0.9942157837239252 0.012218251119378633 0.09809715418336427 0.10523244442562245 0.01053433084921445 0.031593033198759383 1.2019130152165882e-07 6.920126961932622 -0.4115439937605494 AQTGAPCLSFDIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQTGAPCLSFDIVR 14 0 Q9BQ67 Q9BQ67 GRWD1 Glutamate-rich WD repeat-containing protein 1 0 18067500.0 2739600.0 5949400.0 9378500.0 False True 3546466.205589501 5618310.660057092 7671709.231536286 1.0 1.5841996890319174 2.163198177229234 21.75795076948683 -6.971235574507872 0.22674171020742398 0.7547133520196369 3.0091639558346257 0.9999904814929474 0.0014650774398025713 0.07590377569710398 0.0075797616580526245 0.015240999931824485 0.057876188917065745 1.0684751486561712e-07 6.971235574507872 2.254450603814989 AQTK(ub)QQLLEYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQTKQQLLEYK 11 1 B3KVZ3;Q9H3R5;H0Y9E6;D6RBJ6 B3KVZ3 CENPH Centromere protein H 1 5013000.0 1212300.0 2430500.0 1370200.0 True False 1589337.0399299015 2067878.8740147962 1228424.8478864909 1.0 1.3010952504485775 0.7729165161473058 20.599993669010214 -6.752067264865101 1.6420524179520726 1.176605793163931 0.7716902116513791 0.657865532601033 0.12653781375243706 0.2964583192620913 1.5733107144745253 0.06085696110958169 0.14743322438119372 1.7698348196279674e-07 6.752067264865101 -0.404915581512552 AQTK(ub)QQLLEYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQTKQQLLEYK 11 1 B3KVZ3;Q9H3R5;H0Y9E6;D6RBJ6 B3KVZ3 CENPH Centromere protein H 1 17409700.0 2750000.0 5075900.0 9583800.0 True False 4171951.051929831 4170065.98681229 7689557.729271238 1.0 0.9995481574222523 1.8431562675487905 21.992290800635267 -6.906773472721889 0.9174264231818386 0.9711403981437711 1.9449768343494067 0.9896458498850055 0.040455301210444786 0.1065907956157648 0.15062721061008533 0.03260165796334799 0.08810519120385979 1.2394429093115304e-07 6.906773472721889 0.9738364362056356 AQTK(ub)QQLLEYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQTKQQLLEYK 11 1 B3KVZ3;Q9H3R5;H0Y9E6;D6RBJ6 B3KVZ3 CENPH Centromere protein H 1 4683800.0 1212300.0 1875200.0 1596300.0 True False 1660520.0711756551 1792347.4635428437 1219286.8168304716 1.0 1.0793892194713757 0.7342800836892092 20.663203730533105 -6.846191443061747 1.2534439695233928 1.0422628645289806 0.7214735588331312 0.9345602436464704 0.03775189300492102 0.16169818396564503 0.49081311684209183 0.023589925779533834 0.054468334433903524 1.4249793043912588e-07 6.846191443061747 -0.3207893056958494 AQTK(ub)QQLLEYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQTKQQLLEYK 11 1 B3KVZ3;Q9H3R5;H0Y9E6;D6RBJ6 B3KVZ3 CENPH Centromere protein H 1 14368400.0 2750000.0 4343300.0 7275100.0 True False 3559929.2106041457 4101591.5369324563 5951106.44882974 1.0 1.1521553644142228 1.6716923558768728 21.763417122727716 -6.948511755121268 0.5749602967092093 0.9936652935614001 1.8556575937968762 0.9990791812261574 0.008726144505852143 0.08408910484202296 0.038480018761226115 0.00919336288741331 0.043341702409619716 1.1258699943713575e-07 6.948511755121268 0.8619923002354761 AQTMSNSGIK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQTMSNSGIK 10 0 Q12904;Q12904-2 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 1 15654400.0 0.0 7978400.0 7676000.0 True False 0.0 6788053.8195596235 6881761.15339126 0.0 AQTMSNSGIK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQTMSNSGIK 10 0 Q12904;Q12904-2 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 1 17253000.0 0.0 10113000.0 7140000.0 True False 0.0 9666174.220781146 5453679.052915849 0.0 AQVAIK(ub)TADR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQVAIKTADR 10 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 2005130.0 681410.0 830590.0 493130.0 True False 933345.691412854 793891.7874061703 376662.85033114714 1.0 0.8505870811964803 0.40356199615704336 19.83205199808255 -6.951511532731685 0.5419948119812453 1.0064963830090696 0.22693834666536442 0.9993146304495996 0.006633840932196327 0.08288439434830909 0.03349383434901064 0.007276646406366647 0.0370320010178004 1.1181201324024586e-07 6.951511532731685 -0.7795580363437052 down AQVIYTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQVIYTR 7 0 P62851 P62851 RPS25 40S ribosomal protein S25 0 20490500.0 4400700.0 7207800.0 8882000.0 False True 5769360.316439415 6132424.335784342 7962975.84216013 1.0 1.0629296836098796 1.380218153383513 22.459979936815266 -6.939619177875876 0.6630987722678955 0.9964141915859258 1.4648301328216793 0.9981135727655185 0.007227213412685781 0.08794080931490295 0.055404436093780284 0.0070150110535101085 0.027354524470307336 1.1491608506437613e-07 6.939619177875876 0.4684159412357535 AQVIYTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQVIYTR 7 0 P62851 P62851 RPS25 40S ribosomal protein S25 0 18307000.0 3554500.0 3459500.0 11293000.0 False True 3441664.3431349313 4840896.39105417 8335024.517261954 1.0 1.4065568017143448 2.4218005262156903 21.714674971145122 -6.95548587598185 0.49496996992506326 0.978750722045468 2.8930221513855265 0.9995644249310949 0.012478752471207354 0.08135484231377964 0.027403246098908526 0.014776603652136757 0.08373775315967422 1.1079345967643946e-07 6.95548587598185 1.9142714293400585 up AQVIYTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQVIYTR 7 0 P62851 P62851 RPS25 40S ribosomal protein S25 0 36009800.0 1700600.0 33086000.0 1223200.0 False True 2579934.5305134105 27181544.797902115 981433.9838523938 1.0 10.535749832571508 0.3804104221424127 21.298903025010667 -6.66043038378976 1.971694436748336 7.1362687801207985 0.42330412235921866 0.23713162907998464 4.059778259974918 0.483553450642563 3.614305426695892 1.663387459572585 4.499709417635294 2.185594636380424e-07 6.66043038378976 -6.71296465776158 AQVIYTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQVIYTR 7 0 P62851 P62851 RPS25 40S ribosomal protein S25 0 18994400.0 4400700.0 7293300.0 7300400.0 False True 6027757.71444584 6971057.890282113 5576195.876457545 1.0 1.1564927159523357 0.9250862660079878 22.523189998338157 -6.72455117966437 1.74282043743738 1.0947435895351767 0.9253488781568544 0.53390625097686 0.06581894357935704 0.3465740034429084 2.05960408360039 0.029958058211621143 0.07480972920314781 1.8855967472444367e-07 6.72455117966437 -0.1693947113783223 AQVIYTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQVIYTR 7 0 P62851 P62851 RPS25 40S ribosomal protein S25 0 5606900.0 1700600.0 1709600.0 2196700.0 False True 2201460.223837606 1614459.2571408208 1796923.140045398 1.0 0.7333583589925056 0.8162414749029554 21.070029347103116 -10.327902100178463 8.014499089515143 1.0000009247844959 0.7747999169477305 0.9077777225154937 0.03383689037875935 5.591121954035452e-07 4.693491344592967e-08 0.03276256272055575 0.010920809410365075 4.7000004532946434e-11 10.327902100178463 -0.22520100783676533 AQVPFSSCLEAYGAPEQVDDFWSTALQAK(ub)SVAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQVPFSSCLEAYGAPEQVDDFWSTALQAKSVAVK 34 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 625500000.0 170320000.0 292680000.0 162500000.0 True False 258387892.05988705 240448967.2807226 130381803.77371992 1.0 0.9305736633549117 0.5045971881047007 27.94496322667554 -6.935363103971978 0.7013699103392127 1.0053728764678567 0.40386661927039436 0.9974913519627742 0.010969568294096019 0.08994699644189215 0.06472748289077995 0.0103345298383097 0.03747237913977786 1.1604779582748268e-07 6.935363103971978 -0.6015062571974623 AQVPFSSCLEAYGAPEQVDDFWSTALQAK(ub)SVAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQVPFSSCLEAYGAPEQVDDFWSTALQAKSVAVK 34 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 415320000.0 170320000.0 138690000.0 106310000.0 True False 220482597.50912675 130971779.58169198 86962670.83271562 1.0 0.5940232066445538 0.3944196585815161 27.71608954876799 -12.248470427900434 0.1113021979437683 2.3764304036148904 2.6932476545545726e-22 0.9997970395149764 0.003589622963883051 6.213399710647663 0.08278805580093988 2.280194168608931 0.3028569329152431 5.643253662352514e-13 12.248470427900434 -2.3764304036148904 AQVPGSSPGLLSLSLNQQPAAPECK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQVPGSSPGLLSLSLNQQPAAPECK 25 0 Q86W42;Q86W42-2 Q86W42 THOC6 THO complex subunit 6 homolog 0 5322000.0 1270600.0 2217100.0 1834300.0 False True 1665768.9045079025 1886317.3221881117 1644504.2318480453 1.0 1.1324003690328 0.9872343200774665 20.667756835906385 -6.666782187205692 1.9497192848132052 1.0847470322311235 0.9878401820535936 0.2645495950587955 0.05628348074536796 0.46849939622812786 3.430630963323497 0.02327099337146756 0.06241498636203282 2.1538616955102585e-07 6.666782187205692 -0.09690685017752987 AQVPGSSPGLLSLSLNQQPAAPECK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQVPGSSPGLLSLSLNQQPAAPECK 25 0 Q86W42;Q86W42-2 Q86W42 THOC6 THO complex subunit 6 homolog 0 7256700.0 1270600.0 2675900.0 3310200.0 False True 1740375.156673913 2557669.8899820293 2528398.935708966 1.0 1.4696083658595052 1.4527896045936848 20.730966897429276 -10.145019561869187 4.863947444918852 0.9999679883734272 1.461198985228607 0.9990035857168974 0.006866230541434565 2.383678312806757e-06 4.189948221133378e-07 0.006648659634212831 0.0022160663771940456 7.16111153786e-11 10.145019561869187 0.46123099685517976 AQVQLQLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AQVQLQLFK 9 0 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 0 42215000.0 11442000.0 14866000.0 15907000.0 False True 15000572.804485627 12648050.747214127 14261096.230718466 1.0 0.8431711849984806 0.9507034442347405 23.838514256026873 -10.145484210014535 5.644976013156079 1.000001546604674 0.8969373146222487 0.5505207792802858 0.04389986100295262 8.545105275802712e-07 1.2931853091083267e-07 0.042506495453185085 0.014168619213766585 7.153454019769725e-11 10.145484210014535 -0.10306423198242542 AQVQLQLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQVQLQLFK 9 0 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 0 34419900.0 17588000.0 8000100.0 8831800.0 False True 17029678.567184478 11194581.649970362 6518486.631679282 1.0 0.6573571900259986 0.3827721472230339 24.02154786881664 -7.567210125651722 0.20570649887212938 1.19640205513858 8.59560807760107e-14 0.9999307823804152 0.0021006554809212016 0.13152556998668477 0.02146759442263366 0.03639909579382088 0.07152022080337676 2.708880671097384e-08 7.567210125651722 -1.196402055138494 down AQVQLQLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQVQLQLFK 9 0 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 0 151879000.0 30144000.0 60526000.0 61209000.0 False True 45730651.82159018 49724662.408203505 49111014.32114232 1.0 1.0873377139297125 1.073918966052354 25.446658146948668 -10.086049837338026 4.4773179483836385 0.9999935850561483 1.0806283399933203 0.9796492275689928 0.0054781808965018875 3.5672724940098896e-07 7.281370170873766e-08 0.005304654953483678 0.0017680752794738102 8.2025741052618e-11 10.086049837338026 0.08063475493717198 AQVQLQLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AQVQLQLFK 9 0 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 0 54407000.0 11442000.0 16848000.0 26117000.0 False True 15672416.608423524 16103599.651114464 19948702.496499065 1.0 1.0275122244044477 1.272854276077446 23.901724317549764 -6.9281325338095 0.7619526032119376 0.9959994207810515 1.3209093290669263 0.9961586224248293 0.007602037523690866 0.09361870276668004 0.08251226210218345 0.006850453453080272 0.022431410798189087 1.1799604917172461e-07 6.9281325338095 0.32490990828587474 AQVQLQLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQVQLQLFK 9 0 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 0 37528200.0 17588000.0 7906200.0 12034000.0 False True 14625201.280510658 7863607.73134218 14550253.761070687 1.0 0.5376751800210172 0.9948754538141061 23.801953144250916 -10.946483552830829 10.197686976438591 1.066521280910321 0.7662753169175619 0.258405358296381 0.18665123017563864 0.10570733063176621 0.000554740989657959 0.06767475262627357 0.060241425501614626 1.1311402259414796e-11 10.946483552830829 -0.30024596399275916 AQVQLQLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQVQLQLFK 9 0 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 0 122949000.0 30144000.0 48936000.0 43869000.0 False True 39022002.227073275 46212668.581798814 35885292.13395169 1.0 1.1842721014898792 0.9196168849853288 25.217784469041117 -6.719461450629661 1.7610900548536057 1.1121729756402392 0.9200376307382592 0.5100242498967793 0.07754764767234751 0.35637733417342743 2.159759502384301 0.03496619463742533 0.08783927498954362 1.9078250611424397e-07 6.719461450629661 -0.19213534490198003 AQVSLLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQVSLLIR 8 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6 Q99623 PHB2 Prohibitin-2 0 65177000.0 29876000.0 15445000.0 19856000.0 False True 28927602.733295623 21612269.04461095 14655117.932768397 1.0 0.7471157995313336 0.5066136336247586 24.785943434486022 -6.97173445597979 0.21271847569168462 1.1216308829908572 0.12536400393726735 0.9999929350494733 0.0005354099230954291 0.07574380480605294 0.006979598073533015 0.007048895257393469 0.02476747829226656 1.067248477729442e-07 6.97173445597979 -0.9962668790535899 AQVSLLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQVSLLIR 8 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6 Q99623 PHB2 Prohibitin-2 0 258479400.0 60545400.0 74294000.0 123640000.0 False True 91851798.26164086 61035655.23832853 99202499.80666283 1.0 0.6645014729539404 1.0800278457704595 26.452804630706087 -6.691820565032191 1.8598176353914488 0.7900321401977259 1.0786318605530727 0.37912257685413875 0.14183869062542284 0.4127092993231914 2.7690913152661825 0.0609774797601636 0.15843372320889798 2.0331968817518571e-07 6.691820565032191 0.28859972035534676 AQVSLLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AQVSLLIR 8 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6 Q99623 PHB2 Prohibitin-2 0 57902000.0 29876000.0 17052000.0 10974000.0 False True 24843217.731210854 16960137.491443004 13268612.661956906 1.0 0.682686827243629 0.5340939650215832 24.566348709920298 -13.999999999982611 0.10126896031866287 2.5614024135666034 0.22374201871325602 0.9997873448952387 0.0028336773046604086 12.070914693003562 0.09502516424512548 3.9264323430343966 0.2765992224092683 1.0000000000400391e-14 13.999999999982611 -2.3376603948533474 AQVSLLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQVSLLIR 8 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6 Q99623 PHB2 Prohibitin-2 0 274660000.0 60545400.0 105984600.0 108130000.0 False True 78377213.82825899 100086463.84204896 88451449.50749251 1.0 1.2769842018288569 1.1285352615532915 26.223930952798536 -10.186608543207909 4.178188879811434 0.9999213963075295 1.2027597316688967 0.713254516128496 0.06060402616497065 42547385.777206466 5.00227222897149 33155.129377590056 0.02074637011747365 6.507159570939867e-11 10.186608543207909 0.2028383353613672 AQYSLPGILHFLQHEWAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AQYSLPGILHFLQHEWAR 18 0 O43815-2;O43815 O43815-2 STRN Striatin 0 132177000.0 65921000.0 26604000.0 39652000.0 False True 100006976.47064249 21856308.341999255 31814764.81991097 1.0 0.21854783649433973 0.31812545427018624 26.57552540478417 -10.695252183004127 6.845939872274516 1.005998270595459 0.26833664550135017 0.9862984257396595 0.04065239222545332 0.0037189601728186304 0.00016554968173748525 0.03933201051812484 0.013120503172722717 2.017194693392709e-11 10.695252183004127 -0.7376616250941089 AQYSLPGILHFLQHEWAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AQYSLPGILHFLQHEWAR 18 0 O43815-2;O43815 O43815-2 STRN Striatin 0 102141400.0 65921000.0 28185000.0 8035400.0 False True 85336033.99717683 26616479.973393757 6573039.650166527 1.0 0.31190200348746355 0.07702537067030774 26.34665172687662 -9.71169862643778 0.3039377800541412 1.405352986845936 3.5447358764447935e-23 0.9986780153460199 0.014240149028990597 1.116520051735408 0.13209497989834637 0.5077893718485199 0.08086784408383152 1.9422332000096447e-10 9.71169862643778 -1.405352986845936 AQYYLPDGSTIEIGPSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AQYYLPDGSTIEIGPSR 17 0 P61163;R4GMT0 P61163 ACTR1A Alpha-centractin 0 4118000.0 1316200.0 1433900.0 1367900.0 False True 1274417.9514514538 2006463.747689718 1009605.9538796277 1.0 1.5744157914634882 0.7922094574466503 20.281407063245723 -6.709910527049755 1.7956825801610392 1.353171547839893 0.7940639635060208 0.4646251339753029 0.24205876581038657 0.37524492859585457 2.358607878739483 0.10727923743350475 0.2725530514045464 1.9502463463337882e-07 6.709910527049755 -0.5591075843338721 AREEEEQK(ub)EGGDGAAGDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AREEEEQKEGGDGAAGDPK 19 2 Q13442 Q13442 PDAP1 28 kDa heat- and acid-stable phosphoprotein 1 2373240.0 1106100.0 822720.0 444420.0 True False 1070987.4609485283 1151236.3864281212 328013.06968578446 1.0 1.0749298459652552 0.3062716246885628 20.0305101585316 -6.882954779693565 1.06313666025207 1.0485412535164331 0.24860360341296717 0.9759936146787509 0.05361581158301423 0.12504695825231166 0.2567183524854297 0.03873828668644984 0.09442730350076323 1.3093182468360066e-07 6.882954779693565 -0.799937650103466 down AREEEEQKEGGDGAAGDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AREEEEQKEGGDGAAGDPK 19 2 Q13442 Q13442 PDAP1 28 kDa heat- and acid-stable phosphoprotein 0 3733620.0 793570.0 574350.0 2365700.0 False True 768378.5547282554 803690.9501956818 1746052.2005212612 1.0 1.0459570289281628 2.2723853883959184 19.551457728709718 -6.914821857980541 0.8622483386440926 0.9675695508995368 2.4483854711644533 0.9926176196196094 0.050630950231513205 0.10131522564045849 0.1221087919787978 0.042467080345954415 0.1215415772800042 1.2166849668538804e-07 6.914821857980541 1.4808159202649165 up AREETDKEEPASK(ub)QQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AREETDKEEPASKQQK 16 3 P05455 P05455 SSB Lupus La protein 1 7595200.0 3607000.0 2659700.0 1328500.0 True False 4728811.930237688 2262883.1274293987 1191039.5638718482 1.0 0.47853100542225574 0.25186866837649474 22.17304633478053 -10.86708879117562 0.16691843685591679 1.9494984600292615 5.619686832733594e-13 0.9995664192798446 0.006522219897035625 2.910122262400757 0.09312431553773813 1.258412429949132 0.17936879716292767 1.3580357688253578e-11 10.86708879117562 -1.9494984600286995 AREETDKEEPASK(ub)QQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AREETDKEEPASKQQK 16 3 P05455 P05455 SSB Lupus La protein 1 8872100.0 3188500.0 3621500.0 2062100.0 True False 3087282.81279666 5067583.835873015 1521974.1483260344 1.0 1.6414381652591366 0.4929817709014265 21.557906217463646 -6.755143988305492 1.630904593659011 1.3748269562287896 0.48978497155742373 0.6707753783639672 0.269633823191043 0.29115097862833567 1.5251256895914227 0.1305232816811369 0.3151710337218621 1.7573408792082156e-07 6.755143988305492 -0.8850419846713659 AREETDKEEPASK(ub)QQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AREETDKEEPASKQQK 16 3 P05455 P05455 SSB Lupus La protein 1 7251090.0 3188500.0 3095500.0 967090.0 True False 2651379.0245001246 3078823.9270913606 1169304.0476810567 1.0 1.1612160685595767 0.441017310945013 21.338311492897923 -6.847944584988063 1.2450263397233554 1.085900603582264 0.4133571116516143 0.9372524097205498 0.07730414409791744 0.15973318891437327 0.47751315849211035 0.048611301025789665 0.11234785627778855 1.4192386018316051e-07 6.847944584988063 -0.6725434919306497 down ARENIQK(ub)SLAGSSGPGASSGTSGDHGELVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ARENIQKSLAGSSGPGASSGTSGDHGELVVR 31 2 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7 E9PI39;P29692 EEF1D Elongation factor 1-delta 1 66250300.0 19425300.0 25216000.0 21609000.0 True False 29469600.279655468 20716007.78649275 17337971.678438842 1.0 0.7029619536710915 0.5883341312372067 24.812724156350757 -13.999999999995751 0.13181694768873056 2.412116000944525 0.4314493606335416 0.999637468976531 0.0033029881375490457 11.934333238889659 0.113080469882542 4.359483478437896 0.13962336934446823 1.0000000000097838e-14 13.999999999995751 -1.9806666403109834 ARENIQK(ub)SLAGSSGPGASSGTSGDHGELVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ARENIQKSLAGSSGPGASSGTSGDHGELVVR 31 2 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7 E9PI39;P29692 EEF1D Elongation factor 1-delta 1 86716400.0 19425300.0 36085400.0 31205700.0 True False 25146433.77990862 34077215.768384025 25526582.797521178 1.0 1.3551510351981153 1.0151174127090852 24.583850478443207 -10.127701865417954 5.704546376765883 0.999998043762666 1.1851342239536158 0.2832809542929733 0.13881814508143614 3.453972260500259e-06 5.278900549638435e-07 0.13441151097023596 0.04480336367097591 7.452433932129336e-11 10.127701865417954 0.1851361801909498 ARFEELNADLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ARFEELNADLFR 12 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;P54652;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 49203500.0 8045900.0 20545400.0 20612200.0 False True 10548252.816606436 17480106.405341942 18479447.270183865 1.0 1.6571565650969682 1.7518965075515736 23.330500718920028 -11.337278801762343 0.3384843145605254 3.091224303122464e-08 1.7695386543649143 0.9994383768939323 0.007923894552305875 3.527145513968546 0.1738319162150385 2.652413019560149 0.02937231254808519 4.599611998903894e-12 11.337278801762343 1.7695386234526713 ARFEELNADLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ARFEELNADLFR 12 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;P54652;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 64683500.0 24846800.0 9654900.0 30181800.0 False True 24058051.9344507 13510151.919638366 22276281.145408377 1.0 0.5615646668503558 0.9259386922142744 24.520016491335216 -10.018722909413063 7.061241603270685 1.00000003017355 0.743751679532315 0.3973819331461368 0.14875507294425663 7.069345623013636e-08 9.726275000053024e-09 0.14403149721410033 0.048010493348081176 9.578049795783958e-11 10.018722909413063 -0.2562483506412351 ARFEELNADLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ARFEELNADLFR 12 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;P54652;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 280334100.0 6509500.0 268487000.0 5337600.0 False True 9875387.40819537 220573397.15149453 4282621.020446816 1.0 22.33567029162273 0.43366612806427846 23.23540591506271 -6.426382398856832 3.016361215974933 9.999999999999991 0.31668790597717483 0.25162022953015195 8.81858343509118 0.6882146011384594 11.377990786003258 3.453365235710578 13.229813451327884 3.746429816157997e-07 6.426382398856832 -9.683312094022817 ARFEELNADLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ARFEELNADLFR 12 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;P54652;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 64817500.0 8045900.0 28204300.0 28567300.0 False True 11020686.662271874 26958140.76685228 21820292.1020116 1.0 2.446139845273031 1.979939433058287 23.39371078044292 -10.354383796995993 6.138184535740695 0.9998678830803905 2.2130396391656504 0.9002692673666912 0.1903255213002194 0.00034415029989700484 3.6197864247711895e-05 0.18430131401765287 0.061427297862832644 4.421974186195717e-11 10.354383796995993 1.2131717560852597 ARFEELNADLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ARFEELNADLFR 12 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;P54652;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 26736400.0 6509500.0 8271000.0 11955900.0 False True 8426676.07142826 7810711.5792066725 9780048.877893563 1.0 0.9269030294981796 1.1606057708868256 23.00653223715516 -6.822656342816553 1.3603800676568443 0.9607038991841252 1.16600282030787 0.8903785587818038 0.03231875169081152 0.19005032734501298 0.6903672613783729 0.018665639260727916 0.04299303875644008 1.5043318729135477e-07 6.822656342816553 0.20529892112374482 ARFELLCSPLFNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ARFELLCSPLFNK 13 1 Q0VDF9 Q0VDF9 HSPA14 Heat shock 70 kDa protein 14 0 3516250.0 918150.0 1567600.0 1030500.0 False True 1203703.541377249 1333720.1904569427 923873.745253999 1.0 1.1080138461094264 0.7675259841779021 20.19904868563332 -6.821388612393148 1.3658456646574746 1.05813813278615 0.7598682558788089 0.8875528969816227 0.04763897209359992 0.19168042402696592 0.7022548929322906 0.02740594451120115 0.06314440088745148 1.5087295190281222e-07 6.821388612393148 -0.2982698769073412 ARFELLCSPLFNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ARFELLCSPLFNK 13 1 Q0VDF9 Q0VDF9 HSPA14 Heat shock 70 kDa protein 14 0 5644450.0 918150.0 1633200.0 3093100.0 False True 1257614.8670707974 1561039.823729828 2362573.484394116 1.0 1.2412701730902402 1.8786144679546914 20.26225874715621 -6.954270454894812 0.5098129604447191 0.9882521405473138 2.1595847339776104 0.9994951878283939 0.008327602026022457 0.0818149564611273 0.02920650173113692 0.009594865845517872 0.052600872359360194 1.1110396169788768e-07 6.954270454894812 1.1713325934302965 ARGDLEEAVQMLVEGK(ub)EEGPAAWEGPNQDLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ARGDLEEAVQMLVEGKEEGPAAWEGPNQDLPR 32 2 Q9H467 Q9H467 CUEDC2 CUE domain-containing protein 2 1 46469000.0 12429000.0 20302000.0 13738000.0 True False 18855701.681613043 16678949.479750015 11022678.278420687 1.0 0.8845573482961036 0.584580646456098 24.168497503036246 -6.95462849679932 0.5054863404974259 1.0057322931537196 0.45034614654183386 0.9995162191940203 0.003850947656035902 0.08167874244270577 0.028670049156569382 0.004470898645129614 0.024751166653918005 1.1101240289963845e-07 6.95462849679932 -0.5553861466118857 ARGDLEEAVQMLVEGK(ub)EEGPAAWEGPNQDLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ARGDLEEAVQMLVEGKEEGPAAWEGPNQDLPR 32 2 Q9H467 Q9H467 CUEDC2 CUE domain-containing protein 2 1 39894000.0 12429000.0 12187000.0 15278000.0 True False 16089585.51221779 11508782.73676602 12497560.765518088 1.0 0.7152939227692788 0.7767484598051291 23.939623825128695 -10.818048591059759 7.183042820189372 1.01252658587996 0.7460211912872039 0.9579359859624673 0.02508870968613402 0.0050642886039402625 0.00012828174185678827 0.02444336854270635 0.008097346232685815 1.5203774127132808e-11 10.818048591059759 -0.266505394592756 ARPAEVGGMQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ARPAEVGGMQLR 12 1 P33316-2;H0YNW5;P33316;H0YNJ9;H0YKC5;H0YMM5;H0YKI0 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 18811200.0 1613800.0 9302400.0 7895000.0 False True 2115707.42806143 7914518.180471205 7078101.134187611 1.0 3.740837733751817 3.3455009139298144 21.012708706573765 -10.009212523602889 6.391409937946009 0.9999988181026572 3.5431693238408575 0.9821989868212261 0.16139558084990238 2.720111306288071e-06 4.2117146468682203e-07 0.1562706690056725 0.052090199731906726 9.790107856385413e-11 10.009212523602889 2.5431705057382 ARPAEVGGMQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ARPAEVGGMQLR 12 1 P33316-2;H0YNW5;P33316;H0YNJ9;H0YKC5;H0YMM5;H0YKI0 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 18929300.0 5512300.0 2207000.0 11210000.0 False True 5337315.05378047 3088266.6093529565 8273764.70720858 1.0 0.5786180089117109 1.550173565517403 22.347682743309466 -6.788832513347418 1.501049237576354 0.7641327864418235 1.560169450229551 0.7975074880383907 0.17900482835291626 0.23709375892262663 1.0553747092048213 0.09387374570792564 0.21996461962082514 1.626175773214922e-07 6.788832513347418 0.7960366637877274 ARPAEVGGMQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ARPAEVGGMQLR 12 1 P33316-2;H0YNW5;P33316;H0YNJ9;H0YKC5;H0YMM5;H0YKI0 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 20384300.0 1613800.0 9873200.0 8897300.0 False True 2210465.4713051794 9436969.377693688 6795940.985645404 1.0 4.269222704538147 3.074438878989912 21.075918768096656 -9.743089730163152 10.828383881784085 1.0000000106894327 3.6718307917640165 0.8695832959595461 0.4877684542539412 0.0 1.1194172208115178e-17 0.47227978207022925 0.15742659167757067 1.8068007819201354e-10 9.743089730163152 2.6718307810745836 ARPLWAWFQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ARPLWAWFQR 10 1 Q86UN3 Q86UN3 RTN4RL2 Reticulon-4 receptor-like 2 0 3933860.0 668160.0 1195700.0 2070000.0 False True 875964.2304706441 1017306.2208020946 1855816.2568420952 1.0 1.161355892643595 2.1185982170127993 19.74051243378812 -6.936075215798393 0.6951209545162731 0.9881862856583219 2.3494242507195664 0.9976032672355729 0.024169535482311533 0.08960363640320626 0.06311141555173377 0.02287868868235376 0.08391075413148501 1.158576683983229e-07 6.936075215798393 1.3612379650612445 up ARPLWAWFQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ARPLWAWFQR 10 1 Q86UN3 Q86UN3 RTN4RL2 Reticulon-4 receptor-like 2 0 3678760.0 668160.0 1268500.0 1742100.0 False True 915196.8083450668 1212453.4756314526 1330651.859675728 1.0 1.3248008128698672 1.4539515954846047 19.80372249531101 -12.44578276886786 0.14602853127266388 7.483617203582768e-22 1.6157399278224907 0.999604886971229 0.0037961176265275376 6.628941752328924 0.10527639056797744 2.0925399686019124 0.1316397500138208 3.582755992975763e-13 12.44578276886786 1.6157399278224907 ARVEK(ub)VESPAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ARVEKVESPAK 11 2 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 4611800.0 1260500.0 2144100.0 1207200.0 True False 1652527.7066993637 1824208.6376363407 1082290.5242800855 1.0 1.1038898956071845 0.6549303348394517 20.6562430298515 -6.845793459645469 1.2552343070317846 1.0552990746580024 0.638388873959671 0.9339565238460428 0.049316265711624646 0.16214427555342265 0.49374823536253803 0.030773943752700005 0.07104661276174164 1.426285740658835e-07 6.845793459645469 -0.4169102006983314 ARVEK(ub)VESPAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ARVEKVESPAK 11 2 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 4209500.0 1260500.0 1568900.0 1380100.0 True False 1726540.913731676 1499580.8103414953 1054148.804051704 1.0 0.8685463509233393 0.6105553570539544 20.71945309137439 -6.960412432138228 0.4295827623020534 1.0102932627862633 0.45892174082533344 0.9997851873538974 0.002370876164917076 0.07955412764867084 0.020589461224240015 0.0033628026865747127 0.02142331378220034 1.0954374088323804e-07 6.960412432138228 -0.5513715219609299 ARYEAANWK(ub)YK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ARYEAANWKYK 11 2 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 70407060.0 18064060.0 32001500.0 20341500.0 True False 23682157.592605855 27227000.940870002 18236756.70944612 1.0 1.1496841381281464 0.7700631430279848 24.497297189703442 -6.7997196904464365 1.4569266897219335 1.0826155069527847 0.7648505713686936 0.8313938652718506 0.06410948080734757 0.22114760234906247 0.9267513534663657 0.034616849021181464 0.0805244923876611 1.5859164707288603e-07 6.7997196904464365 -0.31776493558409113 ARYEAANWK(ub)YK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ARYEAANWKYK 11 2 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 145910230.0 60204650.0 34900580.0 50805000.0 True False 58293486.34010921 48836563.598120324 37497646.382670134 1.0 0.8377705068656705 0.6432561978518968 25.796831351242428 -6.968711789731554 0.28729525110528187 1.0392575288656143 0.43578207510332745 0.9999705158283402 0.000791873370650585 0.07672297482443988 0.010519043169698247 0.0034485220036139103 0.017695372293566995 1.0747023790505657e-07 6.968711789731554 -0.6034754537622868 ARYEAANWK(ub)YK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ARYEAANWKYK 11 2 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 715857200.0 217249000.0 199029000.0 299579200.0 True False 329582616.0293467 163510719.9293255 240367239.80977234 1.0 0.4961145156841833 0.7293080038795783 28.296064908083434 -10.367502516235328 5.9248302292947255 1.000069277891137 0.6127112597818812 0.7862194676165246 0.09520084290307652 8.71345552939495e-05 9.302041229145647e-06 0.0921942252560069 0.030725939925710124 4.2903970344173296e-11 10.367502516235328 -0.38735801810925585 ARYEAANWK(ub)YK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ARYEAANWKYK 11 2 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 83253260.0 18064060.0 37444300.0 27744900.0 True False 24742831.14486616 35789887.01425836 21192126.04415197 1.0 1.4464750134983777 0.8564956014966412 24.560507251226333 -6.704305853943605 1.8153863094065021 1.276063640035789 0.8580944258198115 0.4380827710069267 0.18831832719518676 0.38663740529234414 2.480090610603089 0.08266308709083324 0.21147508844439902 1.9755778400378328e-07 6.704305853943605 -0.41796921421597744 ARYEAANWK(ub)YK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ARYEAANWKYK 11 2 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 156456850.0 60204650.0 68219200.0 28033000.0 True False 50062833.993216634 67851689.62914903 33894570.690052696 1.0 1.3553305759386842 0.677040590523607 25.577236626676704 -6.764357834406822 1.5960167012089617 1.2052760646932457 0.6740107049243125 0.7085039185269832 0.14956188801806802 0.2756658922348489 1.384844926772322 0.07390391645463526 0.1768506312118287 1.7204504357245938e-07 6.764357834406822 -0.5312653597689332 ARYEAANWK(ub)YK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ARYEAANWKYK 11 2 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 687303400.0 217249000.0 268282100.0 201772300.0 True False 281233113.1180144 253351965.29608068 165051811.7586297 1.0 0.9008610774427764 0.5868861242145718 28.067191230175883 -6.950226541478378 0.5563498008177958 1.0041875394979303 0.46864797904435057 0.9992189490082043 0.004921258447000606 0.08339488132862945 0.03558670584572002 0.005298873251113677 0.026079629359365326 1.1214333272822518e-07 6.950226541478378 -0.5355395604535798 ASAAK(ub)SSLIHQGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASAAKSSLIHQGIR 14 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 21833600.0 3826700.0 9089000.0 8917900.0 True False 5016840.757815516 7732956.628644517 7995161.254537261 1.0 1.5413996580612377 1.5936645471718334 22.258347714810093 -11.575943523427842 0.38760117536248084 1.6637668228387803e-12 1.598329897232804 0.9996400947490272 0.005091606219014575 4.1586816710703935 0.19618655363369403 3.4747361425227044 0.013835594423746626 2.6549507949393354e-12 11.575943523427842 1.5983298972311402 ASAAK(ub)SSLIHQGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASAAKSSLIHQGIR 14 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 62293500.0 11374100.0 12930400.0 37989000.0 True False 11013035.421367573 18093576.151145216 28038541.25442883 1.0 1.6429236317573197 2.5459412579413163 23.39270882464888 -6.966326820405033 0.3344990014844514 0.895598183551959 3.3230282863263714 0.9999379410354456 0.004995265411012185 0.07751355660654675 0.013287923798911838 0.012973519779603513 0.07848410812919995 1.0806204440013072e-07 6.966326820405033 2.4274301027744123 ASAAK(ub)SSLIHQGIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASAAKSSLIHQGIR 14 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 83404800.0 15627000.0 24650800.0 43127000.0 True False 23707301.48673003 20251672.142420508 34602929.54676438 1.0 0.8542377610440487 1.4595895516043058 24.498828119807744 -6.843119151381929 1.2678329213447406 0.9224624370560347 1.4807616439957874 0.9296883974443398 0.06840323504151238 0.16518357831155792 0.5144143363004875 0.04228298383163666 0.09750865231664267 1.435095651954207e-07 6.843119151381929 0.5582992069397527 ASAAK(ub)SSLIHQGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASAAKSSLIHQGIR 14 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 20586400.0 3826700.0 8292900.0 8466800.0 True False 5241534.402679102 7926492.257046963 6467116.219219588 1.0 1.5122465385318278 1.2338211909692047 22.321557776332984 -10.10620571208386 4.360644081086355 0.9999667169716987 1.3730338645804228 0.7053114679097026 0.11366667254905273 39585220.71048562 1.622331198919588 18772.16938493355 0.03891112530948987 7.830586438505172e-11 10.10620571208386 0.37306714760872406 ASAAK(ub)SSLIHQGIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASAAKSSLIHQGIR 14 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 41460700.0 11374100.0 15372000.0 14714600.0 True False 9458068.108065512 15289187.984896915 17791354.827376623 1.0 1.6165233544743483 1.8810770470350888 23.173114100083158 -10.633213952935543 0.17492643479089068 4.6335408674245804e-17 2.1619018308533198 0.9995279531189778 0.00802019400007683 2.496865327432131 0.09320618318311916 1.2538387042391228 0.19686347229882564 2.3269446179861575e-11 10.633213952935543 2.1619018308533198 ASAAK(ub)SSLIHQGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASAAKSSLIHQGIR 14 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 57253100.0 15627000.0 21242100.0 20384000.0 True False 20229459.55422221 20059958.461693373 16674321.157502348 1.0 0.9916210765752533 0.8242593487388619 24.269954441900193 -6.917302999362116 0.8444993850804089 1.0040637099162302 0.7988777385672844 0.9933981401335334 0.006576709006534964 0.09978454559352651 0.11403283657105812 0.005587029516329006 0.01632736400776139 1.209753815814977e-07 6.917302999362116 -0.20518597134894578 ASAELALGENSEVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASAELALGENSEVLK 15 0 P00505 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 17543600.0 4252100.0 3297100.0 9994400.0 False True 4117119.4129818664 4613649.224149361 7376566.8144269 1.0 1.1206012654386135 1.7916815313074306 21.97320386253482 -6.9374506296190255 0.6828720887711701 0.99203241423314 1.9598375755024153 0.9978105179239063 0.01629640197217193 0.08894918134237034 0.060052491586470975 0.015572160678790706 0.05843683118563458 1.1549132671937834e-07 6.9374506296190255 0.9678051612692753 ASAELALGENSEVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASAELALGENSEVLK 15 0 P00505 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 10495600.0 4252100.0 3355700.0 2887800.0 False True 3535809.549969259 3337622.1780456975 3491625.6283214153 1.0 0.9439485161395967 0.9875038740001627 21.753609137969097 -10.231960897087768 5.132809786711081 1.0000039152864373 0.9657261950698977 0.45224085658322577 0.017781400387166784 7.967757528858828e-07 1.1923510723922144e-07 0.01721873366728501 0.005738922297638225 5.861909414706988e-11 10.231960897087768 -0.03427772021653963 ASAGSYISALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASAGSYISALR 11 0 X5D2R7;P28062-2;P28062 X5D2R7 PSM8;PSMB8 Proteasome subunit beta type;Proteasome subunit beta type-8 0 7895100.0 1822300.0 2234300.0 3838500.0 False True 2389052.9471783 1900951.1492331873 3441328.8414919684 1.0 0.7956923480822777 1.4404573350107233 21.188007397076184 -6.82148850375199 1.3653814848658916 0.8900420030232821 1.4549925817113956 0.8877830409233718 0.09012679473096598 0.19155260588036083 0.7012766948174466 0.05186532882636796 0.1194987654120653 1.5083825385408752e-07 6.82148850375199 0.5649505786881135 ASASATVAVNPGPDTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASASATVAVNPGPDTK 16 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 24114600.0 7089600.0 9787200.0 7237800.0 False True 9294534.255784053 8326987.910206786 6488901.885880057 1.0 0.8959015783953719 0.6981416935272435 23.14795114359154 -6.96103842019672 0.42054753318057647 1.0086899927580961 0.5778866320360915 0.9998067821270935 0.0017402351357550957 0.07933230259233598 0.019776373860108488 0.002559094814014037 0.016459506152509365 1.0938595928579872e-07 6.96103842019672 -0.43080336072200465 ASASATVAVNPGPDTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASASATVAVNPGPDTK 16 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 16843200.0 5067100.0 2286700.0 9489400.0 False True 4906247.684090308 3199791.234982968 7003841.464102157 1.0 0.6521870563850788 1.4275352397747476 22.226188637216623 -6.784736413899003 1.5171498282153184 0.8042704800335457 1.43464390254772 0.7838717313530531 0.14741471351936944 0.24328625918483024 1.106250284320745 0.07650358016976747 0.17983548922750997 1.6415857976380231e-07 6.784736413899003 0.6303734225141743 ASASATVAVNPGPDTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASASATVAVNPGPDTK 16 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 30789200.0 4721900.0 17619000.0 8448300.0 False True 7163467.517129987 14474751.792124663 6778489.8019785695 1.0 2.020634805352466 0.9462581893153252 22.772226670614135 -6.657745579861697 1.9805722287743208 1.658165664031808 0.9507203826234792 0.22623225952923798 0.43479416157425005 0.4897854626609444 3.6908318055370493 0.1774961818154278 0.4819764240102673 2.1991478091012734e-07 6.657745579861697 -0.7074452814083289 ASASATVAVNPGPDTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASASATVAVNPGPDTK 16 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 17402300.0 7089600.0 4189000.0 6123700.0 False True 9710816.709236084 4003916.1288294415 4677408.181560326 1.0 0.41231507593190025 0.48166990703383195 23.211161205114433 -10.391344860146095 5.903694057257358 1.0001410643577606 0.4469924914840855 0.9883410485059507 0.028313991232775296 5.258394016076844e-05 5.421300971744708e-06 0.027421795649518375 0.009138301375766537 4.061207128861607e-11 10.391344860146095 -0.5531485728736751 ASASATVAVNPGPDTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASASATVAVNPGPDTK 16 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 8172900.0 5067100.0 3105800.0 0.0 False True 4213518.160591053 3089068.4389469693 0.0 1.0 0.7331328170930795 0.0 22.0065939126509 -7.364869695081177 0.7798058975682931 0.9896884250104839 4.947814291437375e-17 0.9877037403332865 0.046881665474186915 0.11023379081260509 0.13817221176445776 0.040356758843689534 0.0719839532808398 4.3164856844438787e-08 7.364869695081177 -0.9896884250104839 down ASASATVAVNPGPDTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASASATVAVNPGPDTK 16 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 20966400.0 4721900.0 10711000.0 5533500.0 False True 6112592.632564258 10114923.434274293 4526459.77850467 1.0 1.6547681225128594 0.7405138949372128 22.543352992706584 -6.714422046887433 1.7791014864915544 1.4006914103822308 0.7423345837530622 0.4862642771112762 0.27573183021445913 0.36623836151010464 2.2622366054604717 0.12320207881742935 0.3113641767751027 1.9300917443598596e-07 6.714422046887433 -0.6583568266291686 ASASGFADFTSFGNEEQQLAWAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASASGFADFTSFGNEEQQLAWAKR 24 1 Q9UBC2-2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 7950800.0 2831500.0 2302100.0 2817200.0 True False 2741615.5823847414 3221340.5352929016 2079290.8058115987 1.0 1.1749789270204252 0.758418072603369 21.386594866091574 -6.79261741730923 1.4860648257195515 1.0974639142072347 0.7536755537859451 0.8096323118028865 0.07451470727796482 0.23147218339306622 1.0098066218297794 0.03946385524676316 0.09221328049171824 1.6120651250933862e-07 6.79261741730923 -0.3437883604212896 ASASGFADFTSFGNEEQQLAWAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASASGFADFTSFGNEEQQLAWAKR 24 1 Q9UBC2-2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 19999900.0 5262000.0 10594000.0 4143900.0 True False 7982838.703729007 8703417.928700205 3324856.3486641045 1.0 1.0902660383999234 0.4165005046526834 22.928470430501772 -6.8731167376725235 1.1174176607291701 1.0521575661650773 0.37462152314736413 0.9676988779625006 0.053670001698931935 0.1339045664043078 0.3105896774174497 0.03719895013908073 0.08858286428071982 1.3393166328361784e-07 6.8731167376725235 -0.6775360430177131 down ASASGFADFTSFGNEEQQLAWAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASASGFADFTSFGNEEQQLAWAKR 24 1 Q9UBC2-2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 8224300.0 2831500.0 3269800.0 2123000.0 True False 2354517.706718554 3252184.938395515 2566909.484357075 1.0 1.3812531242026729 1.0902060651455143 21.16700014152585 -10.322803677428693 6.006711898041384 0.9999798311345895 1.2357295946740903 0.4665706590732377 0.11881946430462105 3.209619148935062e-05 3.618656140696849e-06 0.11505628709426152 0.03834881720475683 4.755501495332853e-11 10.322803677428693 0.23574976353950072 ASASGSGAQVGGPISSGSSASSVTVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASASGSGAQVGGPISSGSSASSVTVTR 27 0 P02545;P02545-3;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 0 15227000.0 3059200.0 5996400.0 6171400.0 False True 4010640.825334946 5101760.493784129 5532842.728248934 1.0 1.2720561915085125 1.3795408188383118 21.935401340086347 -13.04327791185789 0.13860855173007866 9.877699736619553e-24 1.5214807676827118 0.9996249102486792 0.003093493885994164 8.467987506022498 0.10789323703403376 2.4251113875208183 0.11980459853230532 9.051531937914713e-14 13.04327791185789 1.5214807676827118 ASASGSGAQVGGPISSGSSASSVTVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASASGSGAQVGGPISSGSSASSVTVTR 27 0 P02545;P02545-3;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 0 13892200.0 3508700.0 1034900.0 9348600.0 False True 3397318.2390652755 1448140.966932204 6899921.208011621 1.0 0.42626002777138705 2.0309905409126574 21.69596493632457 -6.810020895927198 1.414408998065994 0.6873271623500652 2.0590890616022848 0.8598968339558141 0.2485129905320609 0.2067680426714854 0.8152608605213612 0.13815366234773613 0.3195801955612363 1.5487420999349615e-07 6.810020895927198 1.3717618992522196 up ASASGSGAQVGGPISSGSSASSVTVTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASASGSGAQVGGPISSGSSASSVTVTR 27 0 P02545;P02545-3;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 0 31555900.0 2695500.0 24806000.0 4054400.0 False True 4089270.567446138 20379175.489837382 3253046.062893349 1.0 4.98357229088041 0.7955076606547378 21.963412091566983 -6.657520826321825 1.9819237187522856 3.569412397443977 0.8131102320770156 0.22505924645271114 1.6971281276624548 0.4903239986319206 3.6998749483558506 0.6924966928044702 1.8806016513857577 2.200286193751213e-07 6.657520826321825 -2.7563021653669617 ASASGSGAQVGGPISSGSSASSVTVTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASASGSGAQVGGPISSGSSASSVTVTR 27 0 P02545;P02545-3;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 0 6358300.0 3508700.0 1531000.0 1318600.0 False True 2917639.511765275 1522752.1991202938 1594313.1634824483 1.0 0.5219123860161103 0.5464393928905331 21.476370211758848 -10.448732261382558 6.030156251408509 1.0002207960822758 0.5341758894533234 0.99792506489908 0.010013108626678832 2.9736684048414698e-05 2.7184724690625507e-06 0.009699654354451267 0.0032317169129076977 3.558506296528885e-11 10.448732261382558 -0.46604490662895237 ASASGSGAQVGGPISSGSSASSVTVTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASASGSGAQVGGPISSGSSASSVTVTR 27 0 P02545;P02545-3;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 0 10310400.0 2695500.0 4255600.0 3359300.0 False True 3489377.8862485425 4018772.1190269473 2747941.8693287703 1.0 1.1517159362030465 0.7875162733615831 21.734538413659433 -6.793540808037906 1.4819985340113704 1.084403845741448 0.7832467703846243 0.8126559349361377 0.06465315304668297 0.23010242763671176 0.9982469115799664 0.034330872979897537 0.08018020166023156 1.6086412164563447e-07 6.793540808037906 -0.3011570753568237 ASAYNNLK(ub)GNLQNLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASAYNNLKGNLQNLER 16 1 E7EV59;P21283 E7EV59 ATP6V1C1 V-type proton ATPase subunit C 1 1 15237600.0 3531400.0 3638200.0 8068000.0 True False 3419297.639990626 5090952.232962357 5954748.765188122 1.0 1.4888882949003275 1.7415122613322562 21.70526858000093 -10.476999257550343 0.1333142205372938 9.911584445950237e-17 2.1758951283121886 0.9997764179509747 0.004602434674221526 2.319993046616429 0.07066060853345248 1.0272422453984509 0.2715552655217329 3.334269827740173e-11 10.476999257550343 2.1758951283121886 ASAYNNLK(ub)GNLQNLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASAYNNLKGNLQNLER 16 1 E7EV59;P21283 E7EV59 ATP6V1C1 V-type proton ATPase subunit C 1 1 6684700.0 1174600.0 2748500.0 2761600.0 True False 1608881.3623714624 2627062.181925933 2109366.956937313 1.0 1.6328501550006709 1.3110767557330292 20.617626516125917 -10.209115264365682 5.413729435874903 0.9999753241727226 1.47196345536691 0.7415020279962192 0.13136344016797225 3.91262316722327e-05 5.715869224731996e-06 0.12719874273566112 0.04239736800589201 6.178523966361542e-11 10.209115264365682 0.4719881311941875 ASAYNNLK(ub)GNLQNLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASAYNNLKGNLQNLER 16 1 E7EV59;P21283 E7EV59 ATP6V1C1 V-type proton ATPase subunit C 1 1 8659500.0 3531400.0 2856100.0 2272000.0 True False 2936515.567545783 2840713.6224085386 2747064.695458915 1.0 0.9673756385983299 0.9354844652687461 21.485673855435206 -6.971404782521246 0.22210391942378965 1.0143216280108505 0.8876357643818844 0.9999913122607652 7.741892295044691e-05 0.07584959088352372 0.007378280361899053 0.0008693020703406852 0.0032180861475405065 1.0680589348907721e-07 6.971404782521246 -0.12668586362896606 ASAYVFASPGCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASAYVFASPGCK 12 0 O95861-4;O95861;O95861-3;O95861-2;A6NF51 O95861-4 BPNT1 3(2),5-bisphosphate nucleotidase 1 0 29618500.0 10086000.0 7704500.0 11828000.0 False True 13222843.67296294 6555018.631905788 10604152.022187587 1.0 0.4957344119033177 0.8019569983928757 23.656529136950283 -10.341728099115496 6.04954189436566 1.000036580913139 0.6488457051480989 0.63680162374371 0.12501484743578548 6.168583444388992e-05 6.712311817914794e-06 0.12105768260854054 0.04034836851228805 4.552730059543727e-11 10.341728099115496 -0.35119087576504016 ASAYVFASPGCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASAYVFASPGCK 12 0 O95861-4;O95861;O95861-3;O95861-2;A6NF51 O95861-4 BPNT1 3(2),5-bisphosphate nucleotidase 1 0 5170390.0 4359500.0 810890.0 0.0 False True 4221110.058769656 1134682.6057354854 0.0 1.0 0.26881142399452523 0.0 22.009191015101933 -8.94062594673214 0.47734099182999445 1.1032972605284719 4.0720208931857446e-17 0.9959277879876647 0.026964219458737986 0.468368743367603 0.1972250288496484 0.1583509241317283 0.05660713661046837 1.1464999846935206e-09 8.94062594673214 -1.1032972605284719 ASAYVFASPGCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASAYVFASPGCK 12 0 O95861-4;O95861;O95861-3;O95861-2;A6NF51 O95861-4 BPNT1 3(2),5-bisphosphate nucleotidase 1 0 19100100.0 3695200.0 12126000.0 3278900.0 False True 5605888.555305866 9962020.55912957 2630823.9778070794 1.0 1.7770636110310665 0.46929651773349207 22.41851163329756 -6.745719578031653 1.665593418164871 1.4592498427543399 0.46750478690580766 0.6304278926949708 0.32648106408430033 0.307550952047707 1.6772687826320518 0.15493257735753704 0.3778540516245602 1.7958928523717294e-07 6.745719578031653 -0.9917450558485322 ASAYVFASPGCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASAYVFASPGCK 12 0 O95861-4;O95861;O95861-3;O95861-2;A6NF51 O95861-4 BPNT1 3(2),5-bisphosphate nucleotidase 1 0 23258600.0 10086000.0 6854600.0 6318000.0 False True 13815066.763901379 6551741.106869014 4825818.523294449 1.0 0.4742460690807983 0.3493156135809825 23.719739198473174 -13.999999999999979 0.20187375852917616 3.943655494694111 0.2696617277810887 0.9994871060334837 0.0063851540456384545 12.568560835904709 0.14245850028980558 14.620136026130192 0.0784518974400475 1.000000000000049e-14 13.999999999999979 -3.6739937669130223 ASAYVFASPGCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASAYVFASPGCK 12 0 O95861-4;O95861;O95861-3;O95861-2;A6NF51 O95861-4 BPNT1 3(2),5-bisphosphate nucleotidase 1 0 15671500.0 3695200.0 7465600.0 4510700.0 False True 4783509.24328162 7050132.79721017 3689798.8836904345 1.0 1.4738411569104828 0.7713581590487595 22.18963795539001 -6.724946533269574 1.7411150574814551 1.2867310014573758 0.7721025209413542 0.5359905542498686 0.19928189619591374 0.34576347624895554 2.050910582353572 0.09078195547656605 0.22661607275668438 1.8838810030000626e-07 6.724946533269574 -0.5146284805160216 ASCVNAMEGKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASCVNAMEGKK 11 1 Q15669 Q15669 RHOH Rho-related GTP-binding protein RhoH 1 2273770.0 680570.0 911260.0 681940.0 True False 658965.6778751838 1275130.8701581205 503319.45623852126 1.0 1.9350489911246123 0.7638022330107702 19.3298437990802 -6.6940961986748695 1.8521947357888362 1.5839569857095779 0.767674077113283 0.3895532460520188 0.3951374761101115 0.4079004654535667 2.716253007482114 0.17047960392877703 0.4416077529458075 2.0225711181568443e-07 6.6940961986748695 -0.8162829085962949 ASCVNAMEGKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASCVNAMEGKK 11 1 Q15669 Q15669 RHOH Rho-related GTP-binding protein RhoH 1 10555110.0 3627700.0 3613100.0 3314310.0 True False 5503486.120394853 2968314.075720853 2659235.175786325 1.0 0.5393516056524348 0.48319103884567177 22.391914336208462 -13.999999999999998 0.29683505215679107 5.126368369341244 0.46891438202152375 0.999642760740158 0.004376034297794658 16.385144590412946 0.17294007904636985 41.45041859013939 0.020576261622703654 1.0000000000000041e-14 13.999999999999998 -4.6574539873197205 ASCVNAMEGKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASCVNAMEGKK 11 1 Q15669 Q15669 RHOH Rho-related GTP-binding protein RhoH 1 4154010.0 710370.0 2488570.0 955070.0 True False 973012.9860274275 2378616.748799495 729502.1362840818 1.0 2.444588903700866 0.7497352520056896 19.892099534070486 -6.680932223734461 1.8983636170641969 1.913225882261125 0.7561036189720114 0.3285024311512571 0.6121237843935459 0.43644761068815924 3.041719585452718 0.2586469659722521 0.6814032352513499 2.0848162154192798e-07 6.680932223734461 -1.1571222632891136 ASCVNAMEGKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASCVNAMEGKK 11 1 Q15669 Q15669 RHOH Rho-related GTP-binding protein RhoH 1 3993900.0 680570.0 2903110.0 410220.0 True False 565924.1093630391 2887470.370207785 495995.10535702214 1.0 5.102221874692175 0.8764339549259993 19.110249074514478 -6.652877735930067 1.9980360875110426 3.6557006533268903 0.8940057686644978 0.20606801757099202 1.7496049145935557 0.501380150896131 3.8397327547312647 0.7093361614043315 1.9385312347717194 2.2239358925792597e-07 6.652877735930067 -2.7616948846623925 ASDKDITVSK(ub)NTSLPPLWSPEAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASDKDITVSKNTSLPPLWSPEAER 24 2 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 12049600.0 4499500.0 4544400.0 3005700.0 True False 5898888.073219976 3866393.2339324607 2694698.9967102855 1.0 0.6554444135811421 0.45681473580483667 22.492011604742185 -9.984522571798784 0.11384930466873004 1.7658869039926715 3.1307460806945164e-11 0.9998930347720024 0.0023208894733947856 1.57016501630745 0.05274904472001353 0.596877073823447 0.2463698127098526 1.0362807439072052e-10 9.984522571798784 -1.765886903961364 ASDKDITVSK(ub)NTSLPPLWSPEAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASDKDITVSKNTSLPPLWSPEAER 24 2 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 21285100.0 8982200.0 6007100.0 6295800.0 True False 8697064.977607707 8405766.35661267 4646741.110048513 1.0 0.9665061004206543 0.5342884205203084 23.052097182163994 -6.922374088557746 0.8069387543940916 1.0087457542894034 0.46063954484267877 0.9948149768726546 0.015271641075418795 0.09679531079597331 0.09852814160027705 0.013326195097046573 0.04087011574848975 1.195710137873447e-07 6.922374088557746 -0.5481062094467246 ASDKDITVSK(ub)NTSLPPLWSPEAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASDKDITVSKNTSLPPLWSPEAER 24 2 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 26883500.0 11456000.0 8961500.0 6466000.0 True False 17379589.54578479 7362250.308480929 5187992.265851529 1.0 0.42361474009992106 0.2985106323819836 24.05089067460014 -13.999999999999998 0.21468478547785558 4.399311106926236 0.22808605773301324 0.9994931535742516 0.0068777384993404305 12.860477568412744 0.146825113146333 18.482718126878382 0.07174621270291724 1.0000000000000041e-14 13.999999999999998 -4.171225049193223 ASDKDITVSK(ub)NTSLPPLWSPEAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASDKDITVSKNTSLPPLWSPEAER 24 2 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 12249200.0 4499500.0 5126600.0 2623100.0 True False 6163086.744415446 4900089.860600867 2003577.8044402762 1.0 0.7950707273495676 0.32509323453150757 22.555221666265076 -6.957282661939973 0.47217386401369416 1.0121547548667527 0.08867172054791066 0.9996557642991282 0.005241815577543585 0.08068646476024026 0.0248290330405441 0.006525044295235695 0.03878412975256421 1.1033602606316729e-07 6.957282661939973 -0.923483034318842 down ASDKDITVSK(ub)NTSLPPLWSPEAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASDKDITVSKNTSLPPLWSPEAER 24 2 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 25101900.0 8982200.0 12562000.0 3557700.0 True False 7469097.278928974 12494326.012638228 4301598.621053778 1.0 1.6728026890057917 0.575919480013869 22.83250245759827 -6.740748883463457 1.6842186011238662 1.399965868114491 0.5752017169969718 0.6082308533878007 0.28267672057230236 0.31644115145566015 1.7628055973533956 0.13276940426044698 0.32550347875585245 1.8165657286985186e-07 6.740748883463457 -0.8247641511175193 ASDKDITVSK(ub)NTSLPPLWSPEAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASDKDITVSKNTSLPPLWSPEAER 24 2 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 35125300.0 11456000.0 14477000.0 9192300.0 True False 14830017.831520407 13671342.22369422 7519395.720962961 1.0 0.9218695741981184 0.5070388860208171 23.82201699669259 -6.938474779599167 0.6736021253334605 1.0048019899146698 0.40001871330015354 0.9979572441495926 0.009777567811567793 0.08846935567216246 0.05783001668644349 0.009411151398022947 0.03595018705859569 1.1521929681701898e-07 6.938474779599167 -0.6047832766145163 ASEEHLK(ub)QHYIDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASEEHLKQHYIDLK 14 1 Q32Q12;P22392-2;J3KPD9;P22392;F6XY72 Q32Q12 NME1-NME2;NME2 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B 1 55116700.0 22225700.0 24059000.0 8832000.0 True False 29138107.933984943 20469490.981247455 7918149.362526267 1.0 0.7024989758299669 0.2717454880895342 24.796403864095776 -7.141819832126528 0.37942662279329087 1.0338477256363445 1.2634284717625507e-15 0.9998263558657815 0.003939554241551332 0.08091932269351759 0.019948874480743273 0.007384882866959607 0.03877843787918076 7.214066940223029e-08 7.141819832126528 -1.0338477256363432 down ASEEHLK(ub)QHYIDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASEEHLKQHYIDLK 14 1 Q32Q12;P22392-2;J3KPD9;P22392;F6XY72 Q32Q12 NME1-NME2;NME2 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B 1 76772300.0 26436300.0 27022100.0 23313900.0 True False 25597094.126999013 37812165.44838988 17207290.18799198 1.0 1.4772053913927203 0.6722360789321891 24.609476703869596 -6.746113950760353 1.664459773300268 1.2819086776907815 0.6711203486628448 0.631999625712159 0.2004971937280481 0.3068652713135643 1.6714412886948116 0.09521217054190897 0.23207932668081233 1.7942627840235366e-07 6.746113950760353 -0.6107883290279368 ASEEHLK(ub)QHYIDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASEEHLKQHYIDLK 14 1 Q32Q12;P22392-2;J3KPD9;P22392;F6XY72 Q32Q12 NME1-NME2;NME2 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B 1 175938000.0 65437000.0 48556000.0 61945000.0 True False 99272713.08550279 39890802.43024045 49701543.59854197 1.0 0.40183048483708533 0.5006566462602309 26.564893885428855 -10.04937017866066 5.447346902435569 1.0000033283294338 0.4512435655500855 0.976253026464177 0.04034561145604037 1.7830303968525485e-06 3.111283392097559e-07 0.039064729268849845 0.013021490104867335 8.925443832595107e-11 10.04937017866066 -0.5487597627793483 ASEEHLK(ub)QHYIDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASEEHLKQHYIDLK 14 1 Q32Q12;P22392-2;J3KPD9;P22392;F6XY72 Q32Q12 NME1-NME2;NME2 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B 1 55488400.0 22225700.0 20398200.0 12864500.0 True False 30443141.91695842 19496940.07617301 9826170.052694116 1.0 0.6404378407904144 0.3227712198529819 24.859613925618667 -7.5215531510295905 0.2550169167170865 1.1291807889415182 4.8781425453216756e-12 0.9998462628772092 0.0034302468578902355 0.12711423274443986 0.026064670462204707 0.027558538563790317 0.06674312627748101 3.009170869656558e-08 7.5215531510295905 -1.12918078893664 down ASEEHLK(ub)QHYIDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASEEHLKQHYIDLK 14 1 Q32Q12;P22392-2;J3KPD9;P22392;F6XY72 Q32Q12 NME1-NME2;NME2 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B 1 75033200.0 26436300.0 45301000.0 3295900.0 True False 21982954.77666384 45056954.521455556 3985057.4514802094 1.0 2.049631406660859 0.181279427263826 24.389881979303873 -6.754267050566199 1.634046883952201 1.6140129589024093 0.17632138806655592 0.6671289805655907 0.44118818657145814 0.292659583440212 1.5386832324497712 0.21317445476950161 0.5152341979830571 1.760892928660891e-07 6.754267050566199 -1.4376915708358533 ASEEHLK(ub)QHYIDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASEEHLKQHYIDLK 14 1 Q32Q12;P22392-2;J3KPD9;P22392;F6XY72 Q32Q12 NME1-NME2;NME2 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B 1 178348000.0 65437000.0 53821000.0 59090000.0 True False 84709486.45611046 50825814.037538685 48336226.31460036 1.0 0.6000014421510214 0.5706117264640042 26.336020207521305 -13.999999999999998 0.37048720909811717 6.58875712669844 0.5675881441005144 0.9997917334279184 0.002826481989487387 22.875839974055413 0.19760326346596976 101.55837678648456 0.008201018413828861 1.0000000000000041e-14 13.999999999999998 -6.021168982597926 ASEIDQVVPAAQSSPINCEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASEIDQVVPAAQSSPINCEKR 21 1 O94782;C9JC88;C9JWX4 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 4564500.0 1750200.0 0.0 2814300.0 True False 2294529.1489609126 0.0 2523103.2326718415 1.0 0.0 1.0996169884415892 21.129766703724933 -10.664380858063474 4.262125313239602 1.0167088419179315 0.5498084942246813 0.1826633510435416 0.4489167556971401 0.07197867489715791 0.00566792367261895 0.4389501252671209 0.1448872598872573 2.1658039524464337e-11 10.664380858063474 -0.4669003476932503 ASEIDQVVPAAQSSPINCEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASEIDQVVPAAQSSPINCEKR 21 1 O94782;C9JC88;C9JWX4 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 5571500.0 1750200.0 0.0 3821300.0 True False 2397296.2373765837 0.0 2918787.6421438833 1.0 0.0 1.2175331511544771 21.192976765247824 -6.688437533923386 1.8716476710780967 0.37214951204116065 1.2132841850788494 0.36322425977462536 0.4230650670646431 0.42005490303279297 2.8516237584218076 0.18089676686302425 0.4720532847736129 2.049096757432599e-07 6.688437533923386 0.8411346730376887 ASELK(ub)EEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASELKEEIK 9 1 Q9BPX3;H0Y9Z8 Q9BPX3 NCAPG Condensin complex subunit 3 1 29831410.0 13850000.0 15530400.0 451010.0 True False 18157484.1235908 13213324.857025068 404343.81159340765 1.0 0.7277068104307404 0.022268713487022734 24.114060982816873 -7.357222010477113 0.7377444684481875 0.9920218833435561 8.952172566439405e-17 0.9903649030886481 0.04044196175075488 0.10781073066033174 0.12000883529133699 0.03534988795844213 0.06970571407672042 4.393169800579361e-08 7.357222010477113 -0.992021883343556 down ASELK(ub)EEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASELKEEIK 9 1 Q9BPX3;H0Y9Z8 Q9BPX3 NCAPG Condensin complex subunit 3 1 25159900.0 10538000.0 10341100.0 4280800.0 True False 10203476.958209569 14470355.15812409 3159530.0587527663 1.0 1.4181788440734855 0.309652295163038 23.28255751597747 -6.804492001909791 1.437459654146815 1.22942426413952 0.2925880163583261 0.84500346805297 0.17994986746024433 0.21439430047363886 0.8740565020716862 0.09846251139844553 0.22839472181106263 1.5685847849160527e-07 6.804492001909791 -0.936836247781194 down ASELK(ub)EEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASELKEEIK 9 1 Q9BPX3;H0Y9Z8 Q9BPX3 NCAPG Condensin complex subunit 3 1 43651400.0 23964100.0 3248500.0 16438800.0 True False 36355291.7103824 2668779.7943536523 13189663.974618003 1.0 0.07340828992967474 0.3627990136811714 25.115662035748176 -10.329279383384781 5.6854489073021615 1.0001201714735437 0.21810365428408818 0.9068335230492814 0.1181432682476668 0.000179987534797768 2.1233358360660267e-05 0.11440902131888026 0.038130575865808106 4.685118895993752e-11 10.329279383384781 -0.7820165171894555 ASELK(ub)EEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASELKEEIK 9 1 Q9BPX3;H0Y9Z8 Q9BPX3 NCAPG Condensin complex subunit 3 1 27910800.0 13850000.0 11007800.0 3053000.0 True False 18970719.282176703 10521438.998073235 2331944.2785086934 1.0 0.5546146585995976 0.12292334538414644 24.177271044339765 -7.805665724805103 0.42686808275761007 1.040876082804028 7.827228153178483e-21 0.9973404998871117 0.01846628592996468 0.11214285500483036 0.08015218296538783 0.03343935090019364 0.07840497753424744 1.5643512559676498e-08 7.805665724805103 -1.040876082804028 down ASELK(ub)EEIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASELKEEIK 9 1 Q9BPX3;H0Y9Z8 Q9BPX3 NCAPG Condensin complex subunit 3 1 35951550.0 10538000.0 22382700.0 3030850.0 True False 8762813.912555221 22262119.95248192 3664586.7219329453 1.0 2.5405218203464424 0.4181974829663315 23.062962791411746 -6.712013178165471 1.7879028860851434 1.945114963385569 0.4228534662209899 0.47471847205496753 0.6489659870656129 0.3710423578407904 2.313240596674812 0.28871127314723893 0.7317118534523301 1.9408269845414799e-07 6.712013178165471 -1.5222614971645791 ASELK(ub)EEIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASELKEEIK 9 1 Q9BPX3;H0Y9Z8 Q9BPX3 NCAPG Condensin complex subunit 3 1 56180900.0 23964100.0 16881800.0 15335000.0 True False 31021999.853032276 15942312.989705142 12544187.350387482 1.0 0.5139034577149237 0.40436423859892895 24.886788357840626 -13.999999999999998 0.2093797792647938 3.804127424450334 0.3394564476860002 0.9994896726783356 0.005847726332485587 12.7322391239763 0.14503805779798554 14.683211153781688 0.0651686948014538 1.0000000000000041e-14 13.999999999999998 -3.4646709767643338 ASEVEEILDGNDEK(ub)YK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASEVEEILDGNDEKYK 16 1 G5E975;Q12824-2;Q12824;A0A0G2JSE9;C9JTA6;A0A2R8Y5N5;A0A0G2JRV3;A0A2R8YEE8;A0A0U1RQQ2;A0A0U1RRB8;B5MCL5 G5E975 SMARCB1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 1 6136200.0 2203100.0 2279600.0 1653500.0 True False 2888285.4348507463 1939492.565811206 1482411.6814919813 1.0 0.6715030801349556 0.5132497168059796 21.461781892953397 -13.999999999999046 0.09647179192042953 2.640514193733796 0.15696200644144154 0.9998112518520545 0.002785157110556858 12.108208969254902 0.09176544537330084 3.992227133790768 0.3184690240359746 1.0000000000021965e-14 13.999999999999046 -2.4835521872923545 ASEVEEILDGNDEK(ub)YK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASEVEEILDGNDEKYK 16 1 G5E975;Q12824-2;Q12824;A0A0G2JSE9;C9JTA6;A0A2R8Y5N5;A0A0G2JRV3;A0A2R8YEE8;A0A0U1RQQ2;A0A0U1RRB8;B5MCL5 G5E975 SMARCB1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 1 9280600.0 2691200.0 3890900.0 2698500.0 True False 2605769.3290884024 5444556.660775457 1991681.896735268 1.0 2.0894238795420046 0.7643354592066038 21.313277946971773 -6.688246074185409 1.872487307179746 1.6841119859954141 0.7689896049481901 0.36230111228581163 0.46091397861314837 0.4204494363192578 2.856752934465984 0.1970111490807212 0.5141982762555409 2.0500003056811222e-07 6.688246074185409 -0.915122381047224 ASEVEEILDGNDEK(ub)YK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASEVEEILDGNDEKYK 16 1 G5E975;Q12824-2;Q12824;A0A0G2JSE9;C9JTA6;A0A2R8Y5N5;A0A0G2JRV3;A0A2R8YEE8;A0A0U1RQQ2;A0A0U1RRB8;B5MCL5 G5E975 SMARCB1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 1 7821800.0 2203100.0 2655000.0 2963700.0 True False 3017645.606538876 2537693.3210890824 2263735.0993174654 1.0 0.8409514078095206 0.7501659884819553 21.524991954476288 -13.999999999999995 0.06404879186765827 1.970775623046783 0.3761000543215787 0.9999431513717589 0.0007785055089541958 12.422237787346447 0.06625439015992042 1.8752782428530843 0.3480308542491951 1.0000000000000123e-14 13.999999999999995 -1.5946755687252043 ASEVEEILDGNDEK(ub)YK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASEVEEILDGNDEKYK 16 1 G5E975;Q12824-2;Q12824;A0A0G2JSE9;C9JTA6;A0A2R8Y5N5;A0A0G2JRV3;A0A2R8YEE8;A0A0U1RQQ2;A0A0U1RRB8;B5MCL5 G5E975 SMARCB1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 1 10750300.0 2691200.0 5983500.0 2075600.0 True False 2237852.0403747014 5951265.697868247 2509598.3635099134 1.0 2.6593651369693676 1.1214317650284473 21.09368322240605 -6.628199310638658 2.087386862953279 2.0946598556169405 1.1276171891530518 0.11095937645016785 0.7121071968198578 0.5636648925070868 4.678060957911164 0.27927824627162035 0.7887637674181668 2.3539687297899855e-07 6.628199310638658 -0.9670426664638887 ASEWVQQVSGLMDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASEWVQQVSGLMDGK 15 0 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 9997100.0 0.0 5063600.0 4933500.0 False True 0.0 4308130.617758209 4423028.745473661 0.0 ASEWVQQVSGLMDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASEWVQQVSGLMDGK 15 0 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 8857100.0 3168600.0 1269000.0 4419500.0 False True 3068014.52740395 1775718.317747579 3261900.3678419557 1.0 0.5787841947574256 1.0631958677855626 21.548873883509224 -6.67680424325889 1.9130022864699308 0.7327351292328851 1.061319508174362 0.30965725125126053 0.17864667028574419 0.4456664941417507 3.150370691291039 0.07500629685354714 0.19865507570103794 2.1047269243954684e-07 6.67680424325889 0.32858437894147696 ASEWVQQVSGLMDGKGGGK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASEWVQQVSGLMDGKGGGK 19 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 15270400.0 1714000.0 6292500.0 7263900.0 True False 2347712.119108365 6014476.543485147 5548316.424716444 1.0 2.5618458475093524 2.3632865288541565 21.16282408262835 -9.701692418858487 6.178623213646448 0.999999986108534 2.462566188186875 0.986365208518961 0.08106150241493097 1.5551153436000324e-08 3.217937541245728e-09 0.0784874622098389 0.026162487403280713 1.987502031061492e-10 9.701692418858487 1.4625662020783408 ASFENNCEIGCFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASFENNCEIGCFAK 14 0 P56537;B7ZBH1;F8WD20;A0A0B4J1Y7;P56537-2;F8WDS6 P56537;P56537-2 EIF6 Eukaryotic translation initiation factor 6 0 21036800.0 2720100.0 11560000.0 6756700.0 False True 3566077.4414858674 9835293.060527075 6057581.4988429835 1.0 2.758014435162976 1.6986679617139746 21.765906602414535 -10.127030423748183 4.778307451419014 0.9999297804933626 2.2283411984377968 0.6419199366534063 0.4324763868898178 150923303.78480005 22.879739351383083 137481.31541408566 0.14804817041501134 7.463964690659112e-11 10.127030423748183 1.228411417944434 ASFENNCEIGCFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASFENNCEIGCFAK 14 0 P56537;B7ZBH1;F8WD20;A0A0B4J1Y7;P56537-2;F8WDS6 P56537;P56537-2 EIF6 Eukaryotic translation initiation factor 6 0 16723100.0 2720100.0 6075600.0 7927400.0 False True 3725794.47793854 5807159.902677537 6055111.389927879 1.0 1.5586366712021658 1.6251866348994475 21.829116663937427 -11.553292338291829 0.3572824244307852 1.0801355249540892e-14 1.6347068369306281 0.9995481899007134 0.005959055353102285 4.054479441978172 0.1835428352736215 3.132404981107679 0.019350722839559006 2.7970978647021836e-12 11.553292338291829 1.6347068369306172 ASFWLGELQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASFWLGELQR 10 0 C9J7E5;Q9Y5L0-5;Q9Y5L0;Q9Y5L0-1;Q9Y5L0-3 C9J7E5 TNPO3 Transportin-3 0 9249900.0 1982100.0 2316400.0 4951400.0 False True 2598552.294683703 1970802.1492564823 4439076.625182579 1.0 0.7584231240173556 1.7082883551215602 21.309276662204027 -6.839284619873125 1.2858534834831319 0.8714774625844806 1.7390628233274885 0.9231935760916937 0.11171002638155757 0.16963768804811047 0.5451710961171583 0.06813294271882954 0.15692407532582459 1.4478226953377793e-07 6.839284619873125 0.867585360743008 ASFWLGELQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASFWLGELQR 10 0 C9J7E5;Q9Y5L0-5;Q9Y5L0;Q9Y5L0-1;Q9Y5L0-3 C9J7E5 TNPO3 Transportin-3 0 6469100.0 1982100.0 1837700.0 2649300.0 False True 2714935.9342384404 1756504.337538761 2023589.9040462133 1.0 0.6469781903091107 0.7453545693386113 21.37248672372692 -10.16794718431504 7.587197940237916 1.0000001478040788 0.6961663798238618 0.927104616352477 0.04016198856081863 1.0041394022169662e-07 1.099771504333222e-08 0.03888669733347028 0.01296222607055195 6.792862373656863e-11 10.16794718431504 -0.303833767980217 ASGK(ub)FELLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASGKFELLDR 10 1 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8Y4C5;A0A2R8YG32;A0A2R8Y7F3;A0A2R8Y6N0;A0A2R8YF80;A0A2R8YF58;A0A2R8Y526;A0A2R8Y7Y7;A0A2R8Y6V2;A0A2R8YDA1;A0A2R8Y523;A0A2R8YGP5;A0A2R8YFV8;P51531;P51531-2;F6VDE0;A0A0U1RQZ9 P51532;P51531 SMARCA4;SMARCA2 Transcription activator BRG1;Probable global transcription activator SNF2L2 1 9512500.0 1467300.0 3246800.0 4798400.0 True False 1420721.3646594135 4543264.171838322 3541555.0910856077 1.0 3.1978572891578 2.492786537305728 20.438192206775575 -10.078056543465307 5.422455622764419 0.9999815126502194 2.8453219132329206 0.9013133947828711 0.2878439291037418 6.433258577008793e-05 1.0937904466037013e-05 0.2787064656551302 0.0929012286432203 8.35494233025294e-11 10.078056543465307 1.8453404005827012 ASGK(ub)VDPTYGLESSCIAGTGPDEPEKLEGAEEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASGKVDPTYGLESSCIAGTGPDEPEKLEGAEEEK 34 2 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 11057600.0 2910600.0 3823600.0 4323400.0 True False 3815824.786290491 3253133.784276069 3876056.0409812126 1.0 0.8525375158639201 1.0157845965326082 21.86356349702157 -11.748034482087325 11.843920164361592 0.9378287430768436 0.9407449512646339 0.0 0.07510583826179908 0.0 0.0 0.0 0.021941322746507275 1.7863457370492135e-12 11.748034482087325 0.002916208187790259 ASGK(ub)VDPTYGLESSCIAGTGPDEPEKLEGAEEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASGKVDPTYGLESSCIAGTGPDEPEKLEGAEEEK 34 2 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 10227600.0 2910600.0 4205400.0 3111600.0 True False 3986727.4760074676 4019591.522601898 2376704.165413578 1.0 1.0082433642109248 0.5961541589478654 21.92677355854446 -6.902336042062951 0.9463740910560716 1.016052362157682 0.5507851788518128 0.9876933087717644 0.021338134774688038 0.10970637314744569 0.1678775582670999 0.016833226498571767 0.044333866921923995 1.2521719126420232e-07 6.902336042062951 -0.46526718330586925 ASGK(ub)VDPTYGLESSCIAGTGPDEPEKLEGAEEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASGKVDPTYGLESSCIAGTGPDEPEKLEGAEEEK 34 2 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 12989300.0 6254600.0 3456900.0 3277800.0 True False 5200977.025760856 3438276.9935590727 3963172.825165156 1.0 0.6610829035638902 0.762005447348689 22.31035123446573 -10.381709101684567 8.470470745115595 1.000001670568725 0.7115441754562899 0.9159122217666562 0.041201455969408475 1.299840056076604e-06 9.488389216805746e-08 0.03989336940334331 0.013297712734084767 4.152320794796978e-11 10.381709101684567 -0.288457495112435 ASGLAAGK(ub)GVIVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASGLAAGKGVIVAK 14 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;H7C366 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 4893870.0 1497400.0 2693580.0 702890.0 True False 1963105.9008422266 2291708.363492604 630161.6853969753 1.0 1.1673890657194794 0.3210023896961537 20.904706571215808 -6.855343258426772 1.2091174845505492 1.0899135949127061 0.283531757821038 0.9477107200193847 0.08368653361895621 0.15168167026169602 0.4240666887571677 0.05407652207378688 0.12563443112135733 1.3952651330489577e-07 6.855343258426772 -0.8063818370916681 down ASGLLFVPNILAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASGLLFVPNILAR 13 0 Q14249 Q14249 ENDOG Endonuclease G, mitochondrial 0 3766050.0 929050.0 1635800.0 1201200.0 False True 1217993.5469329974 1391745.0162984587 1076911.3467240212 1.0 1.1426538505092914 0.8841683516597997 20.21607505902784 -6.756889300386442 1.6242279184539414 1.083181158117621 0.8833680121124327 0.6781242458254013 0.05997671491892265 0.2881737938913408 1.4976156508212655 0.029145759642463645 0.07025733210629455 1.7502927731362766e-07 6.756889300386442 -0.1998131460051883 ASGLLFVPNILAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASGLLFVPNILAR 13 0 Q14249 Q14249 ENDOG Endonuclease G, mitochondrial 0 4941750.0 929050.0 1447000.0 2565700.0 False True 1272544.89163222 1383066.7554108875 1959734.5022501661 1.0 1.0868510529612103 1.5400120774808406 20.279285120550732 -6.938859458054918 0.6700930612925484 0.9947992871784249 1.6582201165660337 0.9980106306513876 0.010560190160848786 0.0882908552769162 0.05700879359477679 0.010192798383990342 0.03920272518059792 1.1511728594782751e-07 6.938859458054918 0.6634208293876088 ASGLVPNVVVLVATVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASGLVPNVVVLVATVR 16 0 A0A087WVM4;B7ZM99;Q6UB35 A0A087WVM4 MTHFD1L Monofunctional C1-tetrahydrofolate synthase, mitochondrial 0 53354000.0 13282000.0 20779000.0 19293000.0 False True 20149765.044266205 17070825.102931995 15479730.093577702 1.0 0.847197228624244 0.7682337764024001 24.2642596805604 -13.999999999999552 0.08401005864649079 1.80537034728517 0.5489762142558033 0.9998696029039136 0.0010985704063627188 12.219321592320723 0.08269375795760558 1.797355329552554 0.19818555617695566 1.0000000000010307e-14 13.999999999999552 -1.2563941330293669 ASGLVPNVVVLVATVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASGLVPNVVVLVATVR 16 0 A0A087WVM4;B7ZM99;Q6UB35 A0A087WVM4 MTHFD1L Monofunctional C1-tetrahydrofolate synthase, mitochondrial 0 33620300.0 13282000.0 12499000.0 7839300.0 False True 17193810.827361565 11803419.662495969 6412627.838010602 1.0 0.68649235361555 0.3729614046820728 24.03538600265285 -7.156732346345925 0.25129184415475936 1.1080377578079088 2.3619193643347073e-11 0.999973490509011 0.0013179992888830545 0.08377372842289839 0.011264454900608243 0.009915580482522862 0.03513863400254423 6.970559740904876e-08 7.156732346345925 -1.1080377577842897 down ASGNYATVISHNPETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASGNYATVISHNPETK 16 0 P62917;E9PKZ0;G3V1A1 P62917 RPL8 60S ribosomal protein L8 0 17735000.0 3868600.0 12778600.0 1087800.0 False True 5071772.06357569 10872082.690592678 975244.8909144105 1.0 2.1436457621338105 0.19228878559397353 22.274058478417754 -6.747856202121277 1.657716189474892 1.6742018883207648 0.189021705486702 0.6397184561446151 0.4805258841838178 0.30380062022039667 1.6418803808641511 0.22904982453205067 0.5573421264476535 1.7870791910676986e-07 6.747856202121277 -1.4851801828340627 ASGNYATVISHNPETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASGNYATVISHNPETK 16 0 P62917;E9PKZ0;G3V1A1 P62917 RPL8 60S ribosomal protein L8 0 13290770.0 7453570.0 3661200.0 2176000.0 False True 7216960.50022795 5123136.252905769 1606040.321399278 1.0 0.709874503642351 0.22253694215848221 22.782959927970133 -7.183448744178329 0.4433705856876855 1.0191660499747595 7.103181830244439e-13 0.9995363770377007 0.006907081472758626 0.08589838679388312 0.02900915663522347 0.009184010235115765 0.0446187185265204 6.55467640143527e-08 7.183448744178329 -1.0191660499740491 down ASGNYATVISHNPETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASGNYATVISHNPETK 16 0 P62917;E9PKZ0;G3V1A1 P62917 RPL8 60S ribosomal protein L8 0 30975100.0 3868600.0 10262000.0 16844500.0 False True 5298925.964984023 9808590.908104017 12866176.023367072 1.0 1.8510526421619087 2.4280724260705657 22.337268539940645 -8.129438552286855 0.14505452713297448 3.197057447980017e-18 3.6128653586487127 0.9999440269182036 0.0043884673123422285 0.09179047823809837 0.02790111684677289 0.29715604337781154 0.3300370280158811 7.422692129325509e-09 8.129438552286855 3.6128653586487127 ASGNYATVISHNPETKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASGNYATVISHNPETKK 17 1 P62917;E9PKZ0;G3V1A1 P62917 RPL8 60S ribosomal protein L8 1 11223750.0 2561050.0 3285900.0 5376800.0 True False 3357561.3512434824 2795656.528337883 4820460.31390752 1.0 0.8326449574190218 1.4357028240518221 21.6789823309504 -6.832683923716708 1.3159913481207255 0.9107319756566968 1.4528249700621862 0.9111157917460908 0.07578350106981391 0.17752293728373128 0.6003357696289467 0.045203063002173714 0.10401851260660729 1.4699957403541233e-07 6.832683923716708 0.5420929944054894 ASGNYATVISHNPETKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASGNYATVISHNPETKK 17 1 P62917;E9PKZ0;G3V1A1 P62917 RPL8 60S ribosomal protein L8 1 24204500.0 7050800.0 4638700.0 12515000.0 True False 6826976.21341279 6490957.100500937 9236946.058047764 1.0 0.9507806820460741 1.353006919798573 22.70281529456526 -6.876289398927111 1.1003400159509011 0.9707669281157199 1.3795533232561814 0.9705645554550132 0.030734733614652492 0.13096500958735457 0.29261210910409347 0.021584452064410977 0.05173648876896742 1.3295681441717588e-07 6.876289398927111 0.40878639514046156 ASGNYATVISHNPETKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASGNYATVISHNPETKK 17 1 P62917;E9PKZ0;G3V1A1 P62917 RPL8 60S ribosomal protein L8 1 32021000.0 5772800.0 2821200.0 23427000.0 True False 8757759.648211107 2317734.817863794 18796643.181581136 1.0 0.26464928371689483 2.1462844307928237 23.062130425703902 -6.800744778550366 1.4531937609179524 0.5946600542932128 2.1726410297109733 0.8342389489468465 0.31522899700878315 0.21970102078308204 0.9159406295168799 0.1706569621514849 0.39664894865766165 1.5821775629903753e-07 6.800744778550366 1.5779809754177605 ASGNYATVISHNPETKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASGNYATVISHNPETKK 17 1 P62917;E9PKZ0;G3V1A1 P62917 RPL8 60S ribosomal protein L8 1 14261750.0 2561050.0 1109600.0 10591100.0 True False 3507939.3947739103 1060574.203043484 8089700.310551404 1.0 0.3023353837365365 2.30611176538664 21.742192392473292 -6.812653320598811 1.4033601841264178 0.62096099265593 2.343337724411352 0.8666558135956031 0.30327322841767523 0.20319300717381836 0.7881876457597762 0.16990174711056352 0.39256490474677486 1.539382976012749e-07 6.812653320598811 1.7223767317554217 ASGNYATVISHNPETKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASGNYATVISHNPETKK 17 1 P62917;E9PKZ0;G3V1A1 P62917 RPL8 60S ribosomal protein L8 1 23766100.0 7050800.0 5131000.0 11584300.0 True False 5863052.603401434 5103358.284576237 14006523.570248542 1.0 0.87042682878464 2.3889472801459597 22.483220569999535 -6.88614914202787 1.0448682784931909 0.9107183466263372 2.510122280165945 0.9783178632705954 0.10120912647128831 0.12232429418459102 0.2405314161597595 0.07415077653698586 0.18247775307453581 1.2997231605819662e-07 6.88614914202787 1.599403933539608 up ASGNYATVISHNPETKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASGNYATVISHNPETKK 17 1 P62917;E9PKZ0;G3V1A1 P62917 RPL8 60S ribosomal protein L8 1 25046600.0 5772800.0 9546500.0 9727300.0 True False 7473003.398900227 9015228.88295206 7957031.210526523 1.0 1.2063729135033978 1.0647701848626925 22.83325674779635 -10.18379318865475 5.422178997052048 0.9999949121187816 1.1355715491830674 0.5499899869106298 0.05780907189266611 3.555777466361575e-06 5.351985517089332e-07 0.055975494045907286 0.018657797724988684 6.549479865218845e-11 10.18379318865475 0.1355766370642858 ASGPPVSELITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASGPPVSELITK 12 0 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 0 14370200.0 4029800.0 2615800.0 7724600.0 False True 3901876.204801 3660302.581216795 5701295.526967302 1.0 0.9380878298273623 1.4611677120745747 21.895736575473865 -6.877366607358141 1.0943264622641211 0.9628102302118592 1.4964235310959497 0.9715009280390025 0.03939543545107831 0.1299909071897789 0.2865691234950826 0.02779290054604134 0.0667859998923924 1.326274417620388e-07 6.877366607358141 0.5336133008840905 ASGPPVSELITK(ub)AVAASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASGPPVSELITKAVAASK 18 1 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 1 66309000.0 12463000.0 28039000.0 25807000.0 True False 16339113.691863665 23855690.49516594 23136739.198224112 1.0 1.4600357733629872 1.41603391925386 23.96182639145077 -10.08001941006688 4.954313062725171 0.9999878763026837 1.4380348463109824 0.9924887617307737 0.017963681726150357 2.4056407211304855e-06 4.4673368311427713e-07 0.01739374100339942 0.005797753345563582 8.317265976401338e-11 10.08001941006688 0.43804697000829873 ASGPPVSELITK(ub)AVAASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASGPPVSELITKAVAASK 18 1 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 1 134220000.0 38223000.0 71317000.0 24680000.0 True False 37009631.78721244 99794250.01324184 18215567.615870457 1.0 2.6964399588466788 0.49218451349641085 25.141397446393707 -6.701124046236233 1.8267621257951352 2.0522500647996558 0.4985792513360653 0.4229622973205637 0.7159409963614797 0.39318750571632793 2.5516437581362537 0.3125652192205393 0.8027512900767242 1.9901048300993563e-07 6.701124046236233 -1.5536708134635906 ASGPPVSELITK(ub)AVAASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASGPPVSELITKAVAASK 18 1 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 1 40001000.0 12463000.0 16198000.0 11340000.0 True False 17070907.899911035 15482318.800377034 8661725.554631043 1.0 0.9069417333367324 0.5073968886374335 24.025036452973662 -6.943251150498605 0.6285896647257021 1.0043585587880308 0.3884987514119366 0.99855948592373 0.008110242912613589 0.08631423577258618 0.04808688526048735 0.008104791236466987 0.033926418249149326 1.1395905769883916e-07 6.943251150498605 -0.6158598073760941 ASGQAFELILSPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASGQAFELILSPR 13 0 P16949;P16949-2;A2A2D0 P16949 STMN1 Stathmin 0 191326000.0 61260000.0 67655000.0 62411000.0 False True 80312453.24268395 57561137.717124425 55953308.40858551 1.0 0.7167149724985888 0.6966952963011694 26.25912037347928 -13.999999999999998 0.37620631708635294 5.10332714548647 0.6948184163887376 0.9998013312367661 0.0019521741804335916 23.562355780100024 0.19965795742672737 78.17964714923299 0.005488734016147839 1.0000000000000041e-14 13.999999999999998 -4.408508729097733 ASGQAFELILSPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASGQAFELILSPR 13 0 P16949;P16949-2;A2A2D0 P16949 STMN1 Stathmin 0 185353000.0 85801000.0 38275000.0 61277000.0 False True 83077294.22009295 53558407.10148815 45226715.42940419 1.0 0.6446816498332055 0.544393216630131 26.307950893407792 -13.999999999999998 0.17743724294094576 2.8294266748928005 0.462585100646686 0.9995014530976757 0.004364544267768375 12.172631238480527 0.13350745029322603 7.673234955832782 0.0765421226795016 1.0000000000000041e-14 13.999999999999998 -2.3668415742461146 ASGQAFELILSPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASGQAFELILSPR 13 0 P16949;P16949-2;A2A2D0 P16949 STMN1 Stathmin 0 313294000.0 70060000.0 167300000.0 75934000.0 False True 106286142.07207417 137444007.87913394 60925611.61694545 1.0 1.293150783344184 0.5732225333348812 26.663378265025308 -6.796124816882865 1.4714714826254656 1.162542799308246 0.564184251436018 0.8206780325765577 0.1251727545484226 0.2263185623684601 0.967761119717026 0.06693217281248873 0.1560558109910344 1.5990983793028755e-07 6.796124816882865 -0.598358547872228 ASGQAFELILSPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASGQAFELILSPR 13 0 P16949;P16949-2;A2A2D0 P16949 STMN1 Stathmin 0 207507000.0 61260000.0 58490000.0 87757000.0 False True 83909477.48925234 55905718.39943518 67030604.01214789 1.0 0.6662622634802599 0.7988442547593457 26.322330435002172 -10.034235136953255 4.895605762661508 1.0000050030318977 0.7325532595716613 0.8443714521068041 0.05412637129798643 2.955669370251644e-06 5.830581242226217e-07 0.05240861356598376 0.017469211217266606 9.241976567315753e-11 10.034235136953255 -0.26745174346023637 ASGQAFELILSPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASGQAFELILSPR 13 0 P16949;P16949-2;A2A2D0 P16949 STMN1 Stathmin 0 150460000.0 85801000.0 28541000.0 36118000.0 False True 71347333.12878637 28387243.96805506 43670106.809236385 1.0 0.3978739319774478 0.6120776333771176 26.08835616884207 -10.114325693661147 5.1886343633892364 1.0000125656889542 0.5049757826766722 0.8768616344934251 0.0874482949096102 1.2711823947430355e-05 2.169643078539599e-06 0.08467359546720117 0.028223815819618345 7.685538568555258e-11 10.114325693661147 -0.49503678301228204 ASGQAFELILSPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASGQAFELILSPR 13 0 P16949;P16949-2;A2A2D0 P16949 STMN1 Stathmin 0 251391000.0 70060000.0 131100000.0 50231000.0 False True 90694051.08906417 123804169.75383815 41089473.41358421 1.0 1.3650748672838409 0.4530558831607728 26.434504587117758 -6.798115919735672 1.4640447846773053 1.2019123885573442 0.44110727861336574 0.8264645163345367 0.1561283752335489 0.2234630948175794 0.9458732926500791 0.08391066085106905 0.19533439025824553 1.5917837992830062e-07 6.798115919735672 -0.7608051099439784 down ASHTAPQVLFSHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASHTAPQVLFSHR 13 0 O15144;H7C3F9 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 30128000.0 8912000.0 10057000.0 11159000.0 False True 11683718.303930765 8556534.801878965 10004373.724686451 1.0 0.7323468932831324 0.856266255693675 23.47799614433299 -10.046008769714595 4.52676609157589 1.0000096402723786 0.7943065744750414 0.7860357995488682 0.05058986790562215 70053345.89845593 4.478507910893397 7213.695154662541 0.01731825738881322 8.994794181460796e-11 10.046008769714595 -0.20570306579733721 ASHTAPQVLFSHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASHTAPQVLFSHR 13 0 O15144;H7C3F9 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 21154400.0 4778400.0 0.0 16376000.0 False True 4626712.307563925 0.0 12086634.330530584 1.0 0.0 2.612359171494388 22.14155596315829 -6.8029533437922565 1.4438986074662041 0.45031008739818007 2.6510760463619447 0.8406428325124038 0.42961981139316086 0.2165659971048086 0.8910622314232406 0.23404617878836834 0.5433375924419837 1.5741519663529007e-07 6.8029533437922565 2.2007659589637645 ASHTAPQVLFSHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASHTAPQVLFSHR 13 0 O15144;H7C3F9 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 24960200.0 8912000.0 6658200.0 9390000.0 False True 12207007.237744307 6364018.708276961 7172275.393120416 1.0 0.521341438104443 0.5875539559724025 23.541206205855882 -10.494165405772268 6.171878124478082 1.0003364722296668 0.5544476970385364 0.9837066749313363 0.02703114722690252 0.0001252422260940083 1.0264585488712048e-05 0.026191958839580715 0.008724265253222844 3.2050484145086235e-11 10.494165405772268 -0.44588877519113046 ASHTAPQVLFSHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASHTAPQVLFSHR 13 0 O15144;H7C3F9 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 13250400.0 4778400.0 5099800.0 3372200.0 False True 3973451.3190125166 5072326.365168959 4077311.4287088704 1.0 1.2765542995074457 1.0261385131861047 21.921961238592566 -10.676820146324022 2.754919919805468 0.9805201940491093 1.151346406542247 0.3275205200914456 0.10223181962282572 15569499.477061883 14557350.782155117 2132436.724011732 0.041377548629025075 2.1046498545777932e-11 10.676820146324022 0.17082621249313767 ASILNTWISLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASILNTWISLK 11 0 P22234;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 84439000.0 20237000.0 33110000.0 31092000.0 False True 26530902.975386772 28170117.061769146 27874898.09552389 1.0 1.0617850846578085 1.050657722482494 24.661170442527613 -10.084591006983379 4.622742664152555 0.9999967023736136 1.0562214035717024 0.9714591061789696 0.004542726590745031 548081.297268852 1196110.3671907766 10.922511518405155 0.0015550962441652832 8.230173544743471e-11 10.084591006983379 0.056224701198088756 ASILNTWISLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASILNTWISLK 11 0 P22234;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 113845000.0 47131000.0 30582000.0 36132000.0 False True 45634852.20320507 42793552.08302319 26667945.263234694 1.0 0.9377383735674216 0.5843767203295933 25.443632723152486 -6.93702354784553 0.686698735422931 1.004243991145264 0.4968900047638065 0.9977474159553307 0.008686624616576754 0.0891512886210851 0.060993066230250546 0.008275969053610808 0.030833093423238738 1.1560495584243143e-07 6.93702354784553 -0.5073539863814576 ASILNTWISLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASILNTWISLK 11 0 P22234;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 481160000.0 106210000.0 172520000.0 202430000.0 False True 161128334.9910793 141732458.09508768 162419621.7717793 1.0 0.879624667523155 1.008014026712133 27.263634978510023 -11.150866414762154 9.68521481998769 2.6246523333510146 0.9438193471089605 0.20337895368341385 0.052414736402651096 0.04398482499604902 0.0006851519741397321 0.0012139988604771743 0.016916783431943274 7.065348448689397e-12 11.150866414762154 -1.680832986242054 ASILNTWISLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASILNTWISLK 11 0 P22234;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 146414000.0 20237000.0 32820000.0 93357000.0 False True 27719165.784361713 31369903.878773548 71307999.34776808 1.0 1.1317044720181106 2.5725160671320717 24.724380504050504 -6.924770392891221 0.7885180178920561 0.973335154154581 2.832439967105814 0.995407176693671 0.04827151036318102 0.09544536943419271 0.09165383945648103 0.042679015115587166 0.13431136301797628 1.1891307426980239e-07 6.924770392891221 1.8591048129512329 up ASILNTWISLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASILNTWISLK 11 0 P22234;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 104517000.0 47131000.0 25273000.0 32113000.0 False True 39191514.75732017 25136849.33270228 38827679.82626414 1.0 0.6413849908163407 0.9907164871450121 25.224037998586763 -10.770017793287106 9.828151589999775 1.001010178351482 0.8160507391982598 0.2699176081525472 0.14261398618136337 0.0031723879425464966 7.42347961801526e-05 0.13877137914350832 0.046028466118056256 1.6981740758975883e-11 10.770017793287106 -0.18495943915322222 ASILNTWISLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASILNTWISLK 11 0 P22234;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 353884200.0 106210000.0 115534200.0 132140000.0 False True 137490938.71209705 109104620.2072759 108091875.87089682 1.0 0.7935404414958467 0.786174542725603 27.034761300602472 ASILWLIGENCER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASILWLIGENCER 13 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 4198950.0 859650.0 1404600.0 1934700.0 False True 1127009.4748624412 1195039.155087919 1734515.8029528512 1.0 1.0603630064723113 1.5390427868093657 20.104068213742558 -6.9302588286429625 0.7446578971677609 0.9927905858511592 1.637966420321378 0.9965890530095952 0.014083490206729443 0.09250324887273852 0.07702132582859096 0.012850644760247106 0.043250619764595946 1.1741975540109218e-07 6.9302588286429625 0.6451758344702188 ASILWLIGENCER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASILWLIGENCER 13 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 4554250.0 859650.0 1476000.0 2218600.0 False True 1177485.8361677388 1410785.4395207115 1694612.3735012757 1.0 1.198133681261316 1.4391785628747635 20.16727827526545 -6.968503459148136 0.29172384504242854 0.9538620641728137 1.69091544970023 0.9999682422924099 0.001011982351207303 0.0767913404689178 0.010759222412460736 0.004172590716677166 0.021815801120383616 1.075218036265313e-07 6.968503459148136 0.7370533855274164 ASINMLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASINMLR 7 0 P18124;A8MUD9;C9JIJ5 P18124 RPL7 60S ribosomal protein L7 0 8954250.0 2834300.0 941750.0 5178200.0 False True 2744326.6979173813 1317795.686161371 3821874.077329837 1.0 0.4801890704781693 1.3926454456862538 21.38802080645069 -6.752210225105215 1.641932865428107 0.6951518355324583 1.394737395404005 0.6582970903814962 0.21845509017659695 0.29621718621346027 1.571914218679443 0.10507816969339143 0.25448540462625985 1.7692523246108305e-07 6.752210225105215 0.6995855598715467 ASIPFSVVGSNQLIEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASIPFSVVGSNQLIEAK 17 0 Q15019;Q15019-2;Q15019-3;B5MCX3;H7C2Y0 Q15019 SEPT2 Septin-2 0 11359600.0 2115800.0 5573800.0 3670000.0 False True 2773834.289436343 4742210.766502228 3290263.6051258435 1.0 1.7096229520855293 1.1861788635522426 21.40345017207244 -10.635159306466017 4.936067176914787 0.9929155886443213 1.4479009078188911 0.49399170646241397 0.2136951542971475 0.01681437014356347 0.0012428027953347125 0.20882366073907255 0.0689698144798371 2.3165447468134526e-11 10.635159306466017 0.45498531917456986 ASIPFSVVGSNQLIEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASIPFSVVGSNQLIEAK 17 0 Q15019;Q15019-2;Q15019-3;B5MCX3;H7C2Y0 Q15019 SEPT2 Septin-2 0 10536900.0 2408700.0 1862100.0 6266100.0 False True 2332237.136955719 2605646.2407232197 4624820.431029416 1.0 1.117230404848275 1.9829975081634355 21.153283055511213 -6.931615430571499 0.7334106672488646 0.9875918932300618 2.1682749851077348 0.9968463592985658 0.024618134202463383 0.09180747866336417 0.07363405072789307 0.022647862057521992 0.0776526748332806 1.1705354458612139e-07 6.931615430571499 1.180683091877673 ASIPFSVVGSNQLIEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASIPFSVVGSNQLIEAK 17 0 Q15019;Q15019-2;Q15019-3;B5MCX3;H7C2Y0 Q15019 SEPT2 Septin-2 0 12060000.0 2115800.0 4992600.0 4951600.0 False True 2898068.4373450833 4772010.423679608 3782134.0614030967 1.0 1.646617575412139 1.3050533978652017 21.46666023359533 -10.04780545060469 4.369154220167467 0.9999691648660236 1.4758354866230894 0.7212670381536583 0.1394429917917164 32187588.488853503 0.7495758683425884 10653.002587434992 0.04773504502316006 8.957659488550487e-11 10.04780545060469 0.4758663217570658 ASITALEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASITALEAK 9 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 10372600.0 1080600.0 5509700.0 3782300.0 False True 1416677.064545287 4687674.236642386 3390943.878383503 1.0 3.308922233555744 2.39358987538342 20.43407949873303 -10.440178705481378 6.145556936304687 0.9993284925030148 2.8512560544695615 0.8450570139277296 0.37368287043010834 0.0034390382614353657 0.00031327424670051624 0.36191518022290387 0.12060562782823264 3.6292868448404263e-11 10.440178705481378 1.8519275619665467 ASITALEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASITALEAK 9 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 9177860.0 2905300.0 793560.0 5479000.0 False True 2813072.8417808157 1110432.6463607317 4043885.533523271 1.0 0.3947400969744432 1.4375331749188867 21.423715479643107 -6.749363879479667 1.6523165521168748 0.6438226292210859 1.4394890181257167 0.6461585491193738 0.2543263883779671 0.30116769224076134 1.617568168787929 0.12160411109341647 0.2954057489660709 1.780886002850902e-07 6.749363879479667 0.7956663889046308 ASITALEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASITALEAK 9 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 10814100.0 1080600.0 4016700.0 5716800.0 False True 1480127.0221169784 3839228.9125493513 4366609.581191786 1.0 2.593850970343224 2.950158679588434 20.497289560255922 -10.127000371185297 0.3482130459910943 1.3784189426371938e-23 3.023697230198873 0.9989167106708247 0.027907292682426074 1.5175584815084997 0.15857695423950277 1.5909204791653697 0.10600071701186228 7.464481204312368e-11 10.127000371185297 3.023697230198873 ASITPGTILIILTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASITPGTILIILTGR 15 0 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 0 413188000.0 275930000.0 76417000.0 60841000.0 False True 361746902.1099213 65015881.47113303 54545756.94808214 1.0 0.17972754180318357 0.150784309775534 28.430405421108723 ASITPGTILIILTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASITPGTILIILTGR 15 0 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 0 1992600000.0 910220000.0 450270000.0 632110000.0 False True 881325564.3292385 630065159.127031 466541428.1064777 1.0 0.71490625556353 0.5293633215570618 29.715099812614778 -8.580960990653992 0.10896081932146329 1.5448319564486885 5.42160677609593e-13 0.9999681286417551 0.0010927454602954224 0.18986665526743504 0.027853760975641233 0.20044144160491542 0.17270520689337976 2.6244542674175047e-09 8.580960990653992 -1.5448319564481463 ASITPGTILIILTGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASITPGTILIILTGR 15 0 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 0 3591300000.0 0.0 1689200000.0 1902100000.0 False True 0.0 1387749062.2201614 1526149101.2799544 0.0 ASITPGTILIILTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASITPGTILIILTGR 15 0 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 0 549112000.0 275930000.0 70872000.0 202310000.0 False True 377948777.7278713 67740640.69763671 154528544.70523882 1.0 0.17923233170609953 0.4088610780387327 28.493615482631615 -10.223026609315532 5.065109275856369 1.0000819067124809 0.29404670489931856 0.9264811942597502 0.09374554313324197 8.671857258659913e-05 1.330246588802933e-05 0.09077917849985812 0.030256243944457445 5.983749313774689e-11 10.223026609315532 -0.7060352018131624 ASITPGTILIILTGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASITPGTILIILTGR 15 0 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 0 1628540000.0 910220000.0 266650000.0 451670000.0 False True 756888259.5830343 265213503.52411896 546112108.7138761 1.0 0.35039981155239963 0.7215227634984408 29.495505088049054 -10.722432632850742 6.989431995147984 1.0053274082186476 0.5359612875256269 0.6758032072031596 0.15151031068387372 0.01262922566829737 0.0005015366015591463 0.1472999592212519 0.04889974250477951 1.894817412973736e-11 10.722432632850742 -0.46936612069302075 ASITPGTILIILTGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASITPGTILIILTGR 15 0 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 0 2993100000.0 0.0 1598700000.0 1394400000.0 False True 0.0 1509730939.6297545 1140633507.7522204 0.0 ASITPGTILIILTGRHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASITPGTILIILTGRHR 17 1 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 0 3423130.0 1114600.0 866130.0 1442400.0 False True 1461251.3938017532 736906.7801482974 1293154.2844777955 1.0 0.5042984275491976 0.884963593508289 20.4787729701837 -9.810413377713425 6.276097320841584 1.0000000104439193 0.6946310105285933 0.46179547353946815 0.15540590324248302 2.2740974394698775e-08 4.465742095269839e-09 0.15047112439535826 0.050157039596625236 1.5473430987767212e-10 9.810413377713425 -0.30536899991532596 ASITPGTILIILTGRHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASITPGTILIILTGRHR 17 1 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 0 6547900.0 2675200.0 1913500.0 1959200.0 False True 2590277.240330447 2677570.5287706745 1446026.7452598645 1.0 1.0337003649961003 0.5582517279406709 21.304675088797513 -6.889883678604038 1.0230910414801249 1.0256177777251867 0.5174549093214178 0.9808229997749153 0.029998141525895538 0.11923675741399367 0.22240942713309253 0.02234491246210113 0.055681887792542746 1.288594642552619e-07 6.889883678604038 -0.5081628684037689 ASITPGTILIILTGRHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASITPGTILIILTGRHR 17 1 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 0 5372000.0 1114600.0 2216500.0 2040900.0 False True 1526697.7409324278 2118567.7010146747 1558881.4536548972 1.0 1.3876798558179326 1.0210806054529256 20.541983031706593 -13.051812043044912 9.219647126975254 1.0177096253798283 1.1839419194636103 0.0 0.18427116255413928 0.0 0.0 0.0 0.052215813860703106 8.875400446192043e-14 13.051812043044912 0.16623229408378193 ASK(ub)IGEVDVEQHTLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASKIGEVDVEQHTLAK 16 1 P14635;P14635-2;E9PC90;H0YA62 P14635 CCNB1 G2/mitotic-specific cyclin-B1 1 101101100.0 5756100.0 32945000.0 62400000.0 True False 8732424.527277566 27065707.349540137 50066612.64910845 1.0 3.0994493299077135 5.733414871518768 23.057950838053056 -6.9680557926719695 0.30102564694533623 0.54871464918415 8.366803227367342 0.9999629980582997 0.01177964501989851 0.07693875955335351 0.011276235915803614 0.043477524158257064 0.23597314677858566 1.0763269318523416e-07 6.9680557926719695 7.8180885781831915 ASK(ub)IGEVDVEQHTLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASKIGEVDVEQHTLAK 16 1 P14635;P14635-2;E9PC90;H0YA62 P14635 CCNB1 G2/mitotic-specific cyclin-B1 1 80878100.0 5756100.0 27049000.0 48073000.0 True False 7451384.91969401 25543699.372018017 39324207.27063438 1.0 3.4280472217327036 5.277436032958183 22.829077160145506 -7.8548001670250605 0.24647572057344405 8.252044264004325e-22 7.072062710739619 0.9996845186570332 0.03111110136953275 0.1226505826703658 0.04061238424509267 0.34244675437599376 0.5644424015306151 1.3970110232654696e-08 7.8548001670250605 7.072062710739619 ASK(ub)PLPPAPAPDEYLVSPITGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASKPLPPAPAPDEYLVSPITGEK 23 1 Q15459;Q15459-2;H7C1L2 Q15459 SF3A1 Splicing factor 3A subunit 1 1 10769200.0 3502100.0 5211500.0 2055600.0 True False 4591287.014384646 4433964.514267893 1842906.2307075427 1.0 0.9657345533782016 0.4013920769783418 22.130467191155905 -6.919325448780227 0.8297185205602958 1.0127573644555057 0.3117852264676228 0.9939913484022216 0.021275424955372012 0.0985704640638955 0.10768447770145768 0.01826573354361249 0.05436632856975842 1.2041332566255115e-07 6.919325448780227 -0.7009721379878828 down ASK(ub)PLPPAPAPDEYLVSPITGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASKPLPPAPAPDEYLVSPITGEK 23 1 Q15459;Q15459-2;H7C1L2 Q15459 SF3A1 Splicing factor 3A subunit 1 1 18009300.0 6412300.0 7113200.0 4483800.0 True False 6208745.046415554 9953537.854847966 3309358.2688833033 1.0 1.603148104880609 0.5330156487572104 22.5658702599475 -6.753773871552613 1.6357151421270646 1.3530436050512638 0.5302422439494947 0.6650881452119582 0.25351046649992254 0.29352135956236164 1.546202439921901 0.1223695378005424 0.2959317692688324 1.7628937109695316e-07 6.753773871552613 -0.822801361101769 ASK(ub)PLPPAPAPDEYLVSPITGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASKPLPPAPAPDEYLVSPITGEK 23 1 Q15459;Q15459-2;H7C1L2 Q15459 SF3A1 Splicing factor 3A subunit 1 1 11183700.0 3502100.0 4456300.0 3225300.0 True False 4796921.010693937 4259405.930986548 2463550.567138583 1.0 0.8879458138858054 0.5135691335434766 22.193677252678796 -6.949008495322277 0.5696251499966631 1.0046714722413557 0.3786532790059843 0.9991211573679839 0.0061658436143864044 0.08388635353684798 0.037629096716598136 0.00653512964185289 0.031190067355030708 1.1245829755565305e-07 6.949008495322277 -0.6260181932353714 ASK(ub)PLPPAPAPDEYLVSPITGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASKPLPPAPAPDEYLVSPITGEK 23 1 Q15459;Q15459-2;H7C1L2 Q15459 SF3A1 Splicing factor 3A subunit 1 1 14665400.0 6412300.0 6221100.0 2032000.0 True False 5332111.563055395 6187585.699508329 2456881.8050935343 1.0 1.1604381540664412 0.4607708927391041 22.346275535381775 -6.846394924402098 1.2524290508675773 1.0854179124477725 0.43469681230213886 0.9348835503212214 0.07636654237736881 0.16146797072905683 0.48921637010798263 0.0477548551603879 0.11027838652378229 1.4243118108025516e-07 6.846394924402098 -0.6507211001456337 down ASK(ub)TAENATSGETLEENEAGD ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASKTAENATSGETLEENEAGD 21 1 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 192579000.0 100690000.0 66653000.0 25236000.0 True False 132005565.08334698 56708632.21135911 22624820.800805364 1.0 0.42959273857548247 0.17139293170344963 26.976023511022834 -9.487492971186699 0.23815780703478878 1.4355664344844645 5.068342408265539e-21 0.999186026416595 0.009876846722291239 0.8974420469465357 0.09479845375254767 0.40847354940316605 0.11766082602448381 3.2546705095761583e-10 9.487492971186699 -1.4355664344844645 ASK(ub)TAENATSGETLEENEAGD ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASKTAENATSGETLEENEAGD 21 1 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 261459000.0 117660000.0 86371000.0 57428000.0 True False 113924947.70382781 120859390.71881475 42385883.99692911 1.0 1.0608685205018877 0.3720509410030211 26.76350846740466 -6.885355587149721 1.0494458046033353 1.0412355634180563 0.31792415654440404 0.9777560880561639 0.04643716661714403 0.12299325573003887 0.24449789400115582 0.03390391426681992 0.0832281294910171 1.3021002217106182e-07 6.885355587149721 -0.7233114068736524 down ASK(ub)TAENATSGETLEENEAGD ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASKTAENATSGETLEENEAGD 21 1 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 198438000.0 100690000.0 65561000.0 32187000.0 True False 137917814.04493645 62664298.238765165 24585093.512073185 1.0 0.45435971177985646 0.17825901376353645 27.039233572545726 -9.052237730808011 0.25219541042158783 1.3218813137688452 1.6202516558103629e-25 0.9991320370505031 0.010059146508078813 0.5055077307636979 0.08676529470239126 0.2548307746119635 0.11248463881502897 8.86670519795109e-10 9.052237730808011 -1.3218813137688452 ASK(ub)TAENATSGETLEENEAGD ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASKTAENATSGETLEENEAGD 21 1 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 275722000.0 117660000.0 126850000.0 31212000.0 True False 97839503.22179227 126166633.87224638 37738284.8920174 1.0 1.289526517589111 0.38571623576694297 26.543913742838935 -6.820505269927017 1.3695735361380388 1.1559799436877198 0.36575392227653164 0.8855519625758871 0.12748400013672798 0.19283574457720534 0.7105812427169118 0.0731418802529315 0.16856732443418557 1.5118013543634214e-07 6.820505269927017 -0.7902260214111883 down ASLAAVHLFTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASLAAVHLFTAK 12 0 Q9UID3;Q9UID3-2 Q9UID3 VPS51 Vacuolar protein sorting-associated protein 51 homolog 0 5636100.0 1880000.0 1726000.0 2030100.0 False True 2464698.205945897 1468487.5278953055 1820044.7260942678 1.0 0.5958082512303904 0.7384452675396721 21.23297957355796 -10.335046008861708 6.385330833915682 1.000018894163155 0.6671267593850312 0.8789579943014265 0.05823131806513059 1.5663693101882185e-05 1.6311439473126312e-06 0.05638542759853287 0.018794077091163135 4.623320396632735e-11 10.335046008861708 -0.33289213477812374 ASLAAVHLFTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASLAAVHLFTAK 12 0 Q9UID3;Q9UID3-2 Q9UID3 VPS51 Vacuolar protein sorting-associated protein 51 homolog 0 4291380.0 1733800.0 541280.0 2016300.0 False True 1678761.4680341396 757415.9267379105 1488170.5422965817 1.0 0.4511754297201367 0.886469323148843 20.678965824416636 -9.943131530841603 6.815095817172983 1.0000000207683075 0.6688223764344928 0.4355969950186307 0.17770798784163608 5.6214203277277444e-08 8.65303817487067e-09 0.17206502960552428 0.057355006449889404 1.1399045027106946e-10 9.943131530841603 -0.3311776443338147 ASLAAVHLFTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASLAAVHLFTAK 12 0 Q9UID3;Q9UID3-2 Q9UID3 VPS51 Vacuolar protein sorting-associated protein 51 homolog 0 6000200.0 1880000.0 1090400.0 3029800.0 False True 2575086.8050896875 1042222.522529394 2314223.6406896957 1.0 0.40473296685355603 0.8986973317231898 21.29618963508085 -10.15138787950984 7.606575853481387 1.0000001221524324 0.6517151492883844 0.39862362204839275 0.20166010750809585 4.178863212202595e-07 4.6283077191377816e-08 0.19525662932161295 0.06508551983110437 7.056870056110769e-11 10.15138787950984 -0.348284972864048 ASLAAVHLFTAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASLAAVHLFTAK 12 0 Q9UID3;Q9UID3-2 Q9UID3 VPS51 Vacuolar protein sorting-associated protein 51 homolog 0 3532450.0 1733800.0 647250.0 1151400.0 False True 1441731.5203632808 643763.1357809333 1392152.4165279027 1.0 0.4465208165933147 0.9656114171500632 20.459371099850912 -10.658760917630461 9.727682962671087 1.0001408588194927 0.7060661168716892 0.29948213762573794 0.21191785027315252 0.0006476894986535369 2.27203568782768e-05 0.20528486317725722 0.06839619207266638 2.1940124232486867e-11 10.658760917630461 -0.2940747419478035 ASLCISTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASLCISTK 8 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 372760000.0 128500000.0 112710000.0 131550000.0 False True 168464744.39577022 95894107.34013902 117938467.91670425 1.0 0.5692235944326562 0.7000780391156158 27.327871460848925 -10.692557747408673 10.054913185838384 1.0002960758476458 0.6346508167741377 0.9122336508846897 0.05342110334141638 0.0003548360527602915 1.0849550652426635e-05 0.05176424584755983 0.017241586964777584 2.0297486096478728e-11 10.692557747408673 -0.3656452590735081 ASLCISTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASLCISTK 8 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 138669000.0 38908000.0 23972000.0 75789000.0 False True 37672886.83716243 33544144.61232852 55937587.278736055 1.0 0.8904054727029543 1.484823489118875 25.1670232540692 -6.859102720359665 1.1901993357283067 0.9406701303271464 1.5131265160061964 0.9525416607797799 0.056267091735210724 0.14773596818401882 0.39817146661084535 0.0368843190622681 0.08601743723680025 1.3832391732715383e-07 6.859102720359665 0.57245638567905 ASLCISTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASLCISTK 8 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 154122000.0 46441000.0 45165000.0 62516000.0 False True 70454392.29188125 37104952.874244355 50159685.198263824 1.0 0.5266520889219296 0.7119454666567883 26.070186314539033 -10.133699020094593 5.242758662477669 1.000010933955559 0.6192987777890695 0.8491347742768578 0.07564570469554256 9.668009509111348e-06 1.5974243479597718e-06 0.07324574160252027 0.024414546208017588 7.350230860889666e-11 10.133699020094593 -0.38071215616648946 ASLCISTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASLCISTK 8 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 288607000.0 128500000.0 52737000.0 107370000.0 False True 176009922.58192822 50406904.96206217 82011417.35456218 1.0 0.28638672310419894 0.465947692900029 27.391081522371817 -10.745214212976952 10.399911980443603 1.001397392606007 0.37616720800866404 0.9414983247610842 0.07330545895318097 0.00237778227216396 5.825279597067114e-05 0.07105710035362688 0.023659235142646763 1.7979838523362717e-11 10.745214212976952 -0.6252301845973429 ASLCISTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASLCISTK 8 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 110923000.0 38908000.0 26206000.0 45809000.0 False True 32353725.916653857 26064823.076516293 55387450.103115045 1.0 0.8056204451895788 1.7119342064588838 24.947428529503476 -6.85059188389314 1.2321334098287657 0.8962115824898765 1.7486000942865376 0.9411731248290174 0.09449266154454265 0.15680913451856113 0.4577949812664922 0.05999867155206992 0.13890226404980652 1.4106137606507294e-07 6.85059188389314 0.8523885117966611 ASLCISTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASLCISTK 8 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 180232000.0 46441000.0 82089000.0 51702000.0 False True 60118789.98896991 77520674.98796955 42292766.5073188 1.0 1.2894583374381352 0.7034866555876844 25.841312636631482 -6.772383679297924 1.5653004491691436 1.1655188186998502 0.6998872112274909 0.7396094278099559 0.1220742663778734 0.26258995461377227 1.270063980269821 0.06145950731055875 0.14598330491618913 1.6889481639415055e-07 6.772383679297924 -0.4656316074723593 ASLESVYLSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASLESVYLSAK 11 0 E9PN48 E9PN48 ARFGAP2 0 6656400.0 2068900.0 1846200.0 2741300.0 False True 2712347.9352560984 1570754.156431234 2457656.572406396 1.0 0.5791123388021103 0.9060993025492303 21.371110826069664 -9.816213314314815 6.176362814621662 1.0000000125632689 0.7426058206754921 0.4524092095560749 0.13349186895436757 2.3152538800228574e-08 4.365719588892308e-09 0.12925295210636448 0.04308431544277053 1.5268159411891084e-10 9.816213314314815 -0.2573941918877768 ASLESVYLSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASLESVYLSAK 11 0 E9PN48 E9PN48 ARFGAP2 0 7527000.0 2068900.0 3262100.0 2196000.0 False True 2833828.239920241 3117969.635677856 1677350.028039664 1.0 1.1002676844541617 0.5919025029148816 21.434320887592555 -6.855479093849466 1.2083341695494492 1.0538737953237265 0.5693239421933692 0.9479095081795743 0.05017862307585244 0.15153054710939085 0.423004762020943 0.032443027528523655 0.07538838915931774 1.3948288005585276e-07 6.855479093849466 -0.48454985313035726 ASLINNAFQLVSIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASLINNAFQLVSIGK 15 0 Q9NZ08;Q9NZ08-2 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 20885300.0 2652700.0 4837600.0 13395000.0 False True 3477715.38878334 4115848.9368171114 12009013.893912984 1.0 1.1834921713524749 3.453133034590928 21.729708438716187 -6.922962061056092 0.802460784554898 0.9550646686814855 3.845276667091046 0.994964807518246 0.07916807550554122 0.09645999914963214 0.09681437814777395 0.0693041081705724 0.21385754915761138 1.1940924130112596e-07 6.922962061056092 2.8902119984095607 up ASLINNAFQLVSIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASLINNAFQLVSIGK 15 0 Q9NZ08;Q9NZ08-2 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 20046100.0 7223400.0 6247500.0 6575200.0 False True 6994097.120889254 8742159.33028211 4852957.868228186 1.0 1.2499339341702767 0.6938648097599143 22.737706398938936 -6.784501971736649 1.518092839997977 1.1406935465827766 0.6888037727650829 0.7830536306031495 0.10591743942357917 0.24365204460447362 1.1092886200209593 0.05493450754152243 0.1291563180223435 1.6424722026837647e-07 6.784501971736649 -0.4518897738176937 ASLINNAFQLVSIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASLINNAFQLVSIGK 15 0 Q9NZ08;Q9NZ08-2 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 24476300.0 2652700.0 9376600.0 12447000.0 False True 3633474.876522027 8962310.807730291 9507274.954011692 1.0 2.466594957251787 2.6165792463417508 21.79291850023908 -10.54099957283596 0.45431109681082915 8.214035831549573e-18 2.6184058199100986 0.9994904709726614 0.016461992543695406 1.9938945989593806 0.21550655432463303 2.3341241069498393 0.03341337577227006 2.8774012448930603e-11 10.54099957283596 2.6184058199100986 ASLINNAFQLVSIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASLINNAFQLVSIGK 15 0 Q9NZ08;Q9NZ08-2 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 14124000.0 7223400.0 2717800.0 4182800.0 False True 6006577.150877903 2703158.6719589373 5057404.140917929 1.0 0.4500331227018123 0.8419777210684382 22.518111674373213 -9.851176676075752 5.711759668216148 1.0000000970943326 0.646005421884044 0.5209887255172558 0.16001071224357913 1.977923071501083e-07 3.9610580215764956e-08 0.15492974979561971 0.05164323531061865 1.4087155998522177e-10 9.851176676075752 -0.3539946752102886 ASLNGADIYSGCCTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASLNGADIYSGCCTLK 16 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;B4DVF8;M0R1W6 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 46792200.0 3694200.0 22902000.0 20196000.0 False True 4843131.974683685 19485110.871296808 18106311.65371155 1.0 4.023245902269558 3.7385542554607154 22.20750888604184 -10.124240715771565 4.6849091532891505 0.9997731564872003 3.8809000789041166 0.9927291514439802 0.11622487825081008 7151287.027896831 15454223.560072714 10453.131770915395 0.039786867467415284 7.51206408521723e-11 10.124240715771565 2.8811269224169163 ASLNGADIYSGCCTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASLNGADIYSGCCTLK 16 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;B4DVF8;M0R1W6 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 36180200.0 3694200.0 16780000.0 15706000.0 False True 5060045.572001233 16038604.115960414 11996566.275223574 1.0 3.1696560609467386 2.370841547673842 22.27071894756473 -10.294476164820834 5.764552058098952 0.9998482930658964 2.7702488043103024 0.8675163707530624 0.32611465944142587 0.0006358848200115495 7.782548745487774e-05 0.3157849188254834 0.10525305374755595 5.076025967782935e-11 10.294476164820834 1.770400511244406 ASLNGADIYSGCCTLK(ub)IEYAKPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASLNGADIYSGCCTLKIEYAKPTR 24 2 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;B4DVF8;M0R1W6 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 8245400.0 2969600.0 3699000.0 1576800.0 True False 4067541.3704225183 3535565.949042755 1204392.3152153643 1.0 0.8692145025867299 0.29609835660755857 21.95572558875606 -6.942784927052867 0.6331281339587322 1.0062542296091277 0.12800491679987827 0.9985063554799302 0.011814403587344454 0.0865188753888771 0.04899484912557047 0.01175939490099868 0.0487541044386652 1.1408146061948166e-07 6.942784927052867 -0.8782493128092494 down ASLNGADIYSGCCTLK(ub)IEYAKPTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASLNGADIYSGCCTLKIEYAKPTR 24 2 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;B4DVF8;M0R1W6 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 35560700.0 22141000.0 8978800.0 4440900.0 True False 28661960.96435871 8479121.887000462 3632701.7674819576 1.0 0.2958318831549695 0.12674295984141631 24.77263398200333 -13.999999999999975 0.20038967415547215 4.920186166471943 0.017349562916192662 0.999486950440969 0.008565470699552562 12.538612815189197 0.14194050755028925 19.268847846164718 0.1073548488165368 1.0000000000000573e-14 13.999999999999975 -4.90283660355575 ASLPTLGFTHFQPAQLTTVGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASLPTLGFTHFQPAQLTTVGKR 22 1 P30566;A0A0A6YY92;A0A1B0GTJ7;A0A1B0GWJ0;A0A096LNY6;P30566-2;A0A1B0GWF8;A0A1B0GTG9;A0A096LNY5 P30566 ADSL Adenylosuccinate lyase 1 21696600.0 4276500.0 4174100.0 13246000.0 True False 4140744.8483377523 5840839.897643943 9776475.228517834 1.0 1.4105771090891224 2.3610426593762406 21.9814588762631 -6.957088130156567 0.4747002173625197 0.9760086489043333 2.83488512760878 0.9996464743614762 0.01071783802436423 0.08075824546406656 0.02510318339160414 0.01326061157828714 0.07842388010797854 1.1038545950671221e-07 6.957088130156567 1.8588764787044467 up ASLPTLGFTHFQPAQLTTVGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASLPTLGFTHFQPAQLTTVGKR 22 1 P30566;A0A0A6YY92;A0A1B0GTJ7;A0A1B0GWJ0;A0A096LNY6;P30566-2;A0A1B0GWF8;A0A1B0GTG9;A0A096LNY5 P30566 ADSL Adenylosuccinate lyase 1 60488200.0 9424200.0 12528000.0 38536000.0 True False 14297200.401308067 10292280.518289234 30919342.70907118 1.0 0.7198808318688449 2.162615186273974 23.769229338308374 -6.856363173042939 1.2040804464739665 0.8492659781188652 2.2277415371598073 0.9490488547076684 0.14099693672014973 0.1505995917858494 0.416994050653964 0.09145980277683342 0.21268048105148146 1.3919922808859423e-07 6.856363173042939 1.378475559040942 up ASLPTLGFTHFQPAQLTTVGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASLPTLGFTHFQPAQLTTVGKR 22 1 P30566;A0A0A6YY92;A0A1B0GTJ7;A0A1B0GWJ0;A0A096LNY6;P30566-2;A0A1B0GWF8;A0A1B0GTG9;A0A096LNY5 P30566 ADSL Adenylosuccinate lyase 1 14038100.0 1408200.0 3619600.0 9010300.0 True False 1928849.5951740965 3459674.1035834444 6882252.712953458 1.0 1.7936463849951851 3.5680608431951226 20.879309220872816 -6.957808221508443 0.4652945145557612 0.9509248101233098 4.482951240622119 0.9996800757466118 0.01920268624967135 0.08049354961330227 0.024095979626454433 0.024322805568702567 0.146507545049083 1.1020258416198549e-07 6.957808221508443 3.5320264304988087 ASLPVIATVFDKLNHEYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASLPVIATVFDKLNHEYK 18 1 Q96DM3;K7ENL9;A0A087WZD4 Q96DM3 C18orf8 Uncharacterized protein C18orf8 0 86826000.0 24033000.0 38648000.0 24145000.0 False True 31507495.735903077 32881869.048724104 21646707.01519439 1.0 1.0436205188867143 0.6870335616844271 24.90919175550863 -6.876293282574996 1.100225656922424 1.0259135103965078 0.6634885597772676 0.9705722552888516 0.027244254999347253 0.13096595810064315 0.2925373091103432 0.019133907693456863 0.0458664945074109 1.3295562546552235e-07 6.876293282574996 -0.3624249506192402 ASLPVIATVFDKLNHEYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASLPVIATVFDKLNHEYK 18 1 Q96DM3;K7ENL9;A0A087WZD4 Q96DM3 C18orf8 Uncharacterized protein C18orf8 0 264498000.0 73567000.0 98687000.0 92244000.0 False True 71231655.85353987 138093233.74590626 68082529.13931741 1.0 1.9386497771417972 0.9557903480343428 26.08601519182785 -6.656643643584321 1.9853312576261526 1.6058704590283546 0.9599484931036858 0.22128922940658768 0.39998055621414347 0.49240423306089914 3.727503694774183 0.16299313622745584 0.44310625370527223 2.2047347962757567e-07 6.656643643584321 -0.6459219659246688 ASLPVIATVFDKLNHEYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASLPVIATVFDKLNHEYK 18 1 Q96DM3;K7ENL9;A0A087WZD4 Q96DM3 C18orf8 Uncharacterized protein C18orf8 0 423016000.0 83262000.0 83464000.0 256290000.0 False True 126314541.26755716 68569197.09279157 205634169.16410235 1.0 0.5428448411774662 1.6279532593839041 26.91244549012478 -6.792251926958627 1.4873286606472513 0.7452442068282891 1.6402206010335247 0.8085436093056878 0.1946338513167995 0.23200655849427154 1.0138431371288448 0.10299056435636166 0.24073611070232834 1.6134223660134715e-07 6.792251926958627 0.8949763942052357 ASLPVIATVFDKLNHEYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASLPVIATVFDKLNHEYK 18 1 Q96DM3;K7ENL9;A0A087WZD4 Q96DM3 C18orf8 Uncharacterized protein C18orf8 0 156417000.0 24033000.0 74048000.0 58336000.0 False True 32918649.56740452 70776314.51600923 44558238.26763294 1.0 2.1500369986650583 1.3535864579254715 24.97240181703152 -10.166443870144505 4.820967575516663 0.9999279619377827 1.7518117282984675 0.542974674145204 0.3251495717069892 0.0002517805831819641 4.353334024786469e-05 0.3148546748174818 0.10494157301906772 6.816416669717246e-11 10.166443870144505 0.7518837663606849 ASLPVIATVFDKLNHEYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASLPVIATVFDKLNHEYK 18 1 Q96DM3;K7ENL9;A0A087WZD4 Q96DM3 C18orf8 Uncharacterized protein C18orf8 0 229473000.0 73567000.0 95059000.0 60847000.0 False True 61174220.07069176 94546898.2992659 73569826.375259 1.0 1.5455350013454903 1.2026279418069101 25.866420467262127 -10.332183472807094 4.463621237918282 0.9996090815539492 1.3740814715779532 0.613419852250687 0.1399912208505633 0.0005451580238751576 8.156241709064482e-05 0.13568533196851454 0.04518197224662242 4.653894427484819e-11 10.332183472807094 0.374472390024004 ASLPVIATVFDKLNHEYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASLPVIATVFDKLNHEYK 18 1 Q96DM3;K7ENL9;A0A087WZD4 Q96DM3 C18orf8 Uncharacterized protein C18orf8 0 301282000.0 83262000.0 109960000.0 108060000.0 False True 107784300.33939014 103840629.33739157 88394188.78923196 1.0 0.9634114524139343 0.8201026356426419 26.68357181221723 -6.945358146201749 0.6076752696698192 1.001590769063963 0.77448999185239 0.9987847884916842 0.002706202772061474 0.08540501915307758 0.04410179585209643 0.00275688026546225 0.012074373047043757 1.1340752010995352e-07 6.945358146201749 -0.22710077721157296 ASLQSQLPEGVPQHQLPPQYQK(ub)ILER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASLQSQLPEGVPQHQLPPQYQKILER 26 1 Q15750-2;Q15750 Q15750-2 TAB1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 1 57227000.0 23941000.0 18053000.0 15233000.0 True False 36320247.321546234 14831301.101267198 12222190.873138912 1.0 0.4083480205948057 0.33651177440877034 25.114270690858906 -13.999999999999998 0.2974265978461295 6.317816092898253 0.31836079108714727 0.9996440836139702 0.005608584330313399 16.422661315530263 0.17312790202381206 53.666040194501925 0.02625172106050777 1.0000000000000041e-14 13.999999999999998 -5.999455301811106 ASLQSQLPEGVPQHQLPPQYQK(ub)ILER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASLQSQLPEGVPQHQLPPQYQKILER 26 1 Q15750-2;Q15750 Q15750-2 TAB1 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 1 27272500.0 10292000.0 13705000.0 3275500.0 True False 8558254.012907403 13631168.44477048 3960391.905799154 1.0 1.5927510943484735 0.4627569945722765 23.028885068772066 -6.764141029059348 1.5966378421104417 1.3425164194705879 0.45772355262520664 0.7077599799266253 0.24948531337388452 0.27600108721591926 1.3875336684151793 0.12323001414575653 0.29497215996102216 1.72130952095239e-07 6.764141029059348 -0.8847928668453813 down ASLQYLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASLQYLLR 8 0 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4;K7ES92;A0A087X1A3 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 0 11744200.0 4053500.0 4188900.0 3501800.0 False True 5314177.754149844 3563932.4482043134 3139467.3276375076 1.0 0.6706460741591184 0.5907719825867503 22.341415054725328 -13.999999999999982 0.19898635873141182 2.8238215003947222 0.5383769370705602 0.999486914435944 0.004011854103993587 12.511019429841225 0.1414481044555204 8.877057050571276 0.05124664958223272 1.0000000000000409e-14 13.999999999999982 -2.285444563324162 ASLQYLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASLQYLLR 8 0 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4;K7ES92;A0A087X1A3 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 0 9391200.0 4053500.0 2581700.0 2756000.0 False True 5552188.49171865 2467631.9574597683 2105089.5616016937 1.0 0.4444431166449693 0.37914591061552283 22.40462511624822 -13.999999999999998 0.30210770181097885 6.129498906545662 0.3634276034577377 0.9996545282333666 0.0051775774374033965 16.726980270074286 0.1746206680445968 53.69777232867145 0.023386071673568862 1.0000000000000041e-14 13.999999999999998 -5.766071303087925 ASLSLIEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASLSLIEK 8 0 P52292 P52292 KPNA2 Importin subunit alpha-1 0 20843200.0 3421300.0 5038900.0 12383000.0 False True 4485357.431916335 4287115.7614783645 11101725.9461235 1.0 0.9558024809734565 2.475103960974716 22.096791525417714 -6.900198236172912 0.9599943513049035 0.9371761259542015 2.6352347809590615 0.9866652351611808 0.08152839749509766 0.11126016895088692 0.1765896506393996 0.06366994835757565 0.1658272460256139 1.2583508992983811e-07 6.900198236172912 1.69805865500486 up ASLSLIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASLSLIEK 8 0 P52292 P52292 KPNA2 Importin subunit alpha-1 0 13460780.0 2453800.0 961980.0 10045000.0 False True 2375905.4621422137 1346103.630659427 7413913.156459429 1.0 0.5665644749373676 3.120457978902385 21.180046001417377 -6.863222852658273 1.1694462823735674 0.7625338914388389 3.251901919585092 0.9574329993708538 0.2302246525276576 0.14351283845760499 0.3711504806571348 0.15334112736250394 0.3593194683794049 1.370178496174099e-07 6.863222852658273 2.489368028146253 up ASLSLIEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASLSLIEK 8 0 P52292 P52292 KPNA2 Importin subunit alpha-1 0 23075200.0 3421300.0 6018900.0 13635000.0 False True 4686247.067156042 5752965.096159363 10414693.821639715 1.0 1.2276273559026591 2.2223953778775294 22.160001586940606 -6.9428479257837346 0.6325246172181284 0.9891459189147216 2.5147208697871664 0.9985135230837683 0.020464474163793933 0.08649129298622613 0.0488731059251614 0.020379985486697224 0.08460229013252664 1.1406491317002688e-07 6.9428479257837346 1.5255749508724448 up ASLTLSGGPSALAFDLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASLTLSGGPSALAFDLSK 18 0 Q9BUH6 Q9BUH6 C9orf142 Protein PAXX 0 48907000.0 12955000.0 17181000.0 18771000.0 False True 19653682.13736398 14114916.314234298 15060903.622378422 1.0 0.7181817745693652 0.7663146028878659 24.22829629240334 -10.398074437780007 5.889719281945694 1.0000734563146516 0.7422481887286233 0.9745124549147385 0.019650144876219314 1.8958960692557536e-05 1.9375959296452196e-06 0.019031574146288012 0.006342056988013255 3.9987620537630936e-11 10.398074437780007 -0.2578252675860283 ASLTLSGGPSALAFDLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASLTLSGGPSALAFDLSK 18 0 Q9BUH6 Q9BUH6 C9orf142 Protein PAXX 0 32684800.0 12955000.0 9618800.0 10111000.0 False True 16770502.88122789 9083505.324395256 8270901.74762099 1.0 0.5416358345797074 0.4931814988612564 23.99942261449579 -13.999999999999998 0.31742671604985745 5.628623187498087 0.4832831937137621 0.9996881871714496 0.004032324143930095 17.815757229237306 0.17956201569296182 54.687631062817616 0.016296269482833723 1.0000000000000041e-14 13.999999999999998 -5.145339993784325 ASLYNAVTIEDVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASLYNAVTIEDVQK 14 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 6849700.0 1711000.0 2969900.0 2168800.0 False True 2243137.5693475697 2526802.4965795297 1944393.380598617 1.0 1.1264589970353294 0.8668186058531202 21.097086671482373 -6.774266361051745 1.5581302217999384 1.0721374879454562 0.8651169787462335 0.7466077287949349 0.053363195256445894 0.2595860626726407 1.2442906410629093 0.026986202952477067 0.06399010373266942 1.681642361532507e-07 6.774266361051745 -0.20702050919922266 ASLYNAVTIEDVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASLYNAVTIEDVQK 14 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 8124500.0 3024700.0 0.0 5099800.0 False True 2928682.5541370753 0.0 3764009.389279427 1.0 0.0 1.2852227305968562 21.481820394363968 -6.699083193976811 1.8343821438294299 0.37846246466194366 1.2812995751281977 0.41306767122670784 0.4221866076512758 0.39745903763529655 2.5995777363067907 0.18366489194453706 0.47283028205927385 1.9994788103623192e-07 6.699083193976811 0.902837110466254 ASLYNAVTIEDVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASLYNAVTIEDVQK 14 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 12824200.0 2614200.0 0.0 10210000.0 False True 3384133.4335859474 0.0 8351884.76344677 1.0 0.0 2.4679537398136273 21.690355023177293 -6.796711055605029 1.4693613567852026 0.44593418750326297 2.4993028834519495 0.8223662669265883 0.42718007337474084 0.2254787472623942 0.9614045452771313 0.22875389712945143 0.5330848325400904 1.5969412693312184e-07 6.796711055605029 2.0533686959486865 ASNAVK(ub)AEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASNAVKAEIR 10 1 P30154;P30154-2;P30154-4;P30154-3 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 5594460.0 1198460.0 1099300.0 3296700.0 True False 1571192.6659031496 935288.7250378384 2955589.1081793895 1.0 0.5952730975231594 1.8811118281795594 20.583428669816346 -6.822096932625199 1.3628317892332842 0.782308209650478 1.9104533528680563 0.8891291156633965 0.17874513933233058 0.19076922223172355 0.6956443982023064 0.1030528899289757 0.23739144367195827 1.5062708356158028e-07 6.822096932625199 1.1281451432175782 ASNAVK(ub)AEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASNAVKAEIR 10 1 P30154;P30154-2;P30154-4;P30154-3 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 15281600.0 1328320.0 2177480.0 11775800.0 True False 1286153.208685608 3046959.119408194 8691364.713572422 1.0 2.3690483364124653 6.757643377848129 20.294631078432875 -6.949951727816166 0.5593727761337826 0.9424136260676637 8.393790572853554 0.9991974938587433 0.06957302958388734 0.08350512460139838 0.03604254941385058 0.0746349352168733 0.36476168052385627 1.1221431744942535e-07 6.949951727816166 7.45137694678589 ASNAVK(ub)AEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASNAVKAEIR 10 1 P30154;P30154-2;P30154-4;P30154-3 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 63436100.0 413900.0 3264200.0 59758000.0 True False 627916.5601431852 2681678.006688996 47946805.107138135 1.0 4.270755346980318 76.35856123336629 19.260213335678813 -6.913913730136502 0.8706989938553404 4.211501486082074e-13 86.42658100372401 0.9931405921618365 2.880457395897384 0.09839756411886408 0.12161467948909867 2.449155679179711 6.939564305780705 1.2192317675829304e-07 6.913913730136502 86.42658100372358 up ASNAVK(ub)AEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASNAVKAEIR 10 1 P30154;P30154-2;P30154-4;P30154-3 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 6457340.0 1198460.0 895980.0 4362900.0 True False 1641563.049163717 856392.6409903563 3332472.876746019 1.0 0.5216934198333958 2.030060848679388 20.646638731339237 -6.821449631681498 1.36579808515867 0.7425731950004997 2.0639680576710573 0.8876384923861824 0.21096759809826954 0.1916076761374922 0.7019563789187183 0.1213760026929992 0.2796210861562671 1.5085175542478246e-07 6.821449631681498 1.3213948626705576 up ASNAVK(ub)AEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASNAVKAEIR 10 1 P30154;P30154-2;P30154-4;P30154-3 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 15146220.0 1328320.0 3222400.0 10595500.0 True False 1104556.934553554 3205040.2916036793 12810970.061943175 1.0 2.9016524104292643 11.598288563659404 20.07503635386715 -6.941814133713692 0.6424707468156445 0.9046155171669659 14.07414295125296 0.9983919174501814 0.18501133843758558 0.08694885403017182 0.05091454874937762 0.18267295703373757 0.7427255885882843 1.1433675604711478e-07 6.941814133713692 13.169527434085992 ASNGDAWVEAHGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASNGDAWVEAHGK 13 0 P38646;A0A3B3ITI4;D6RJI2 P38646 HSPA9 Stress-70 protein, mitochondrial 0 14520700.0 1326800.0 7468600.0 5725300.0 False True 1739447.648749477 6354313.992374779 5132900.876955582 1.0 3.6530642338923047 2.9508797695899185 20.73019782889362 -10.110537224605865 5.586889129260001 0.9999752958625264 3.301972001741542 0.9347670501503215 0.2866656071432521 8.821076058515735e-05 1.4045386797790007e-05 0.2775657380856675 0.09252092686613367 7.75287488432691e-11 10.110537224605865 2.3019967058790156 ASNGDAWVEAHGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASNGDAWVEAHGK 13 0 P38646;A0A3B3ITI4;D6RJI2 P38646 HSPA9 Stress-70 protein, mitochondrial 0 13078080.0 4013170.0 967910.0 8097000.0 False True 3885774.115048193 1354401.5105839707 5976152.795206781 1.0 0.34855384551018165 1.5379568184530619 21.88977060700204 -6.757997528891754 1.620082769475737 0.6206631275001104 1.5418673187454006 0.6827189168271458 0.2739261450988336 0.2862901908444271 1.4805144790825746 0.1334387854452626 0.3213021359940681 1.7458320865668464e-07 6.757997528891754 0.9212041912452902 ASNGDAWVEAHGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASNGDAWVEAHGK 13 0 P38646;A0A3B3ITI4;D6RJI2 P38646 HSPA9 Stress-70 protein, mitochondrial 0 16295100.0 1326800.0 5957600.0 9010700.0 False True 1817353.8154218073 5694373.532851348 6882558.241191706 1.0 3.1333323673847655 3.7871316981796777 20.79340789041651 -9.607213218425347 0.33531849938147296 1.4396820067544024e-21 3.9656982036661588 0.9985803083549616 0.0448408687562601 0.9647685967978219 0.13916657454711936 1.2678522438623736 0.20154334491238965 2.4705109410664e-10 9.607213218425347 3.9656982036661588 ASNGDAWVEAHGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASNGDAWVEAHGK 13 0 P38646;A0A3B3ITI4;D6RJI2 P38646 HSPA9 Stress-70 protein, mitochondrial 0 5593510.0 4013170.0 816090.0 764250.0 False True 3337128.668575555 811693.5611888188 924051.1415072511 1.0 0.2432311252581364 0.2769000638808692 21.670175882436315 -10.720347570508538 6.854290067417797 1.008961368819974 0.2600655945695028 0.9984495424827424 0.013745286634463392 0.0018677049762650401 7.620154813698373e-05 0.013205511111295767 0.004436272185343674 1.903936367474452e-11 10.720347570508538 -0.7488957742504712 ASNLENSTYDLYTIPK(ub)DADSQNPDAPEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASNLENSTYDLYTIPKDADSQNPDAPEGK 29 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 16274400.0 4785400.0 5950800.0 5538200.0 True False 4633490.096395526 8326985.473012045 4087579.277561339 1.0 1.7971303056177361 0.8821815073568711 22.14366785740317 -6.676442059949368 1.9146532140987056 1.5059653152351407 0.8857671001820657 0.3078253172658414 0.338110546842936 0.4464989865435816 3.161484469940266 0.14186473231604374 0.37585573970280167 2.1064829101264836e-07 6.676442059949368 -0.6201982150530749 ASNLENSTYDLYTIPK(ub)DADSQNPDAPEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASNLENSTYDLYTIPKDADSQNPDAPEGK 29 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 44934000.0 15402000.0 15272000.0 14260000.0 True False 23365960.03702667 12546592.279319378 11441504.749619955 1.0 0.536960272954226 0.48966551049001505 24.47790497863246 -13.999999999999998 0.3224076825662459 5.81626227205619 0.4805262859616081 0.9996988727129387 0.003995312154931503 18.20213657297637 0.18119128851423824 59.20903943163612 0.01559940641707507 1.0000000000000041e-14 13.999999999999998 -5.335735986094582 ASNLENSTYDLYTIPK(ub)DADSQNPDAPEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASNLENSTYDLYTIPKDADSQNPDAPEGK 29 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 14111200.0 3134700.0 6434400.0 4542100.0 True False 4293683.302082257 6150106.932284591 3469349.527485861 1.0 1.4323615645574153 0.8080124413934701 22.033784352657523 -6.720435457748939 1.7578835907437669 1.2629208402421173 0.8089700705833541 0.5145359844283637 0.1819292891036261 0.3544593768237841 2.1409041941052775 0.08217026126744256 0.20616197531572228 1.903551110949051e-07 6.720435457748939 -0.45395076965876313 ASNLENSTYDLYTIPK(ub)DADSQNPDAPEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASNLENSTYDLYTIPKDADSQNPDAPEGK 29 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 15266800.0 4785400.0 8152500.0 2328900.0 True False 3979272.129165092 8108580.864355451 2815862.222383041 1.0 2.037704535190145 0.70763248427894 21.924073132837446 -6.698525750961424 1.8359887193964672 1.6453046065978056 0.7116818812795634 0.4106010508577288 0.4381482174097049 0.39862192298616894 2.611267143231029 0.1904540465469745 0.49071604899254917 2.002046909140831e-07 6.698525750961424 -0.9336227253182422 ASNLENSTYDLYTIPK(ub)DADSQNPDAPEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASNLENSTYDLYTIPKDADSQNPDAPEGK 29 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 42805000.0 15402000.0 14183000.0 13220000.0 True False 19938192.618809137 13393703.582140999 10814095.648654869 1.0 0.6717611690392513 0.5423809397073008 24.24903130072491 -13.999999999999998 0.12860541708805906 2.5597041850902036 0.35794239213763657 0.9996519742725808 0.003593262404860124 11.939092343386 0.11138087821998499 4.713161585015763 0.16394669428460584 1.0000000000000041e-14 13.999999999999998 -2.201761792952567 ASNLQDLVYK(ub)NGQAGITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASNLQDLVYKNGQAGITK 18 1 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 1 13380700.0 3337400.0 4998300.0 5045000.0 True False 3231456.0638003973 6994147.255790156 3723563.153244186 1.0 2.164394971709625 1.152286486255066 21.62375294560096 -6.612182411408194 2.145234813224944 1.7767732326766843 1.155933527668884 0.057341406886067925 0.5017256631701411 0.6066535735645703 5.2934353415069335 0.1929021004285619 0.5569574440940492 2.442404483893579e-07 6.612182411408194 -0.6208397050078003 ASNLQDLVYK(ub)NGQAGITK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASNLQDLVYKNGQAGITK 18 1 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 1 31561500.0 8490300.0 6474200.0 16597000.0 True False 12880405.824072676 5318828.426844514 13316595.675276484 1.0 0.4129395066810671 1.0338646046686353 23.618674713498976 -10.127409191238696 13.704801142115471 0.9999854095028868 0.7234020556848737 0.20922406876629118 0.25349160989949826 0.0 0.0 0.2454421958227722 0.08181406527425739 7.457457873675656e-11 10.127409191238696 -0.27658335381801313 ASNLQDLVYK(ub)NGQAGITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASNLQDLVYKNGQAGITK 18 1 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 1 25331900.0 8490300.0 6198600.0 10643000.0 True False 10990860.718833596 5853642.460992682 8706083.206401955 1.0 0.5325918152126214 0.7921202378157229 23.389801035591425 -10.123368299643372 5.361905472861082 1.0000067304281244 0.6623560265140108 0.6929471039230589 0.10595203485506681 8.524772898559967e-06 1.3936201364574498e-06 0.10258966129096513 0.03419587220745642 7.52716957946057e-11 10.123368299643372 -0.33765070391411356 ASNPDK(ub)VASTAFAENR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASNPDKVASTAFAENR 16 1 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 15260500.0 7858200.0 3750200.0 3652100.0 True False 7608745.7423612075 5247674.417034637 2695505.4493484804 1.0 0.6896898115307684 0.35426409826542443 22.859227222736173 -7.126002265524278 0.27531387835607973 1.0856251666075247 3.2037907496473584e-11 0.9999661319484726 0.0015345491780508467 0.07941283123128666 0.011774544915363772 0.008270078942966759 0.03367100716844788 7.481655976484264e-08 7.126002265524278 -1.0856251665754868 down ASNPDLK(ub)LWEIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASNPDLKLWEIGK 13 1 Q969G3;Q969G3-2;A0A2R8Y855;A0A2U3TZQ7;Q969G3-4;Q969G3-3;Q969G3-5;Q969G3-6;B4DGM3;A0A2R8YES3;A0A2R8Y4T4;A0A2R8Y7I9;A0A2R8Y765;A0A2R8Y7U4;J3QKS7;J3QR61;A0A2R8YD78;J3KT85;J3QKX6;A0A2R8YFC8;A0A2R8YEB8 Q969G3 SMARCE1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 1 24154500.0 9667300.0 8344100.0 6143100.0 True False 9360416.853112482 11675942.64390666 4534037.820950323 1.0 1.2473742171027598 0.48438417776689996 23.15814134897547 -6.81939554757142 1.3743316484735157 1.1334163834232545 0.4679199186509482 0.8830293451464515 0.10870479597709959 0.19426110662902224 0.7211129132143445 0.062156673365841554 0.14329564986734222 1.5156692944039435e-07 6.81939554757142 -0.6654964647723063 down ASNPDLK(ub)LWEIGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASNPDLKLWEIGK 13 1 Q969G3;Q969G3-2;A0A2R8Y855;A0A2U3TZQ7;Q969G3-4;Q969G3-3;Q969G3-5;Q969G3-6;B4DGM3;A0A2R8YES3;A0A2R8Y4T4;A0A2R8Y7I9;A0A2R8Y765;A0A2R8Y7U4;J3QKS7;J3QR61;A0A2R8YD78;J3KT85;J3QKX6;A0A2R8YFC8;A0A2R8YEB8 Q969G3 SMARCE1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 1 44910900.0 13676900.0 17140000.0 14094000.0 True False 20748857.21532334 14081233.084568758 11308314.722380353 1.0 0.6786510186290914 0.5450090385714831 24.306528543553632 -13.999999999667201 0.12035752470073233 2.5312027681981393 0.3327323216155843 0.9996911888339953 0.0033554872355694544 11.962375579543751 0.10681554130311212 4.3791601975378756 0.18837598199408964 1.0000000007662973e-14 13.999999999667201 -2.198470446582555 ASNTAEVFFDGVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASNTAEVFFDGVR 13 0 P49748-2;P49748;P49748-3 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 14417300.0 3318100.0 5642300.0 5456900.0 False True 4350061.23252611 4800490.833513137 4892272.334280981 1.0 1.1035455771562692 1.124644475737645 22.052604278156807 -13.999999999999911 0.223619907477805 0.3650604744209569 1.1355461776546487 0.9995017656377327 0.0012158261872117963 13.101391729635647 0.14978674968601577 3.680524113833205 0.011404753496246842 1.0000000000002045e-14 13.999999999999911 0.7704857032336918 ASNTAEVFFDGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASNTAEVFFDGVR 13 0 P49748-2;P49748;P49748-3 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 11213200.0 4027400.0 1712300.0 5473500.0 False True 3899552.3914873023 2396030.3195265364 4039826.1485197353 1.0 0.6144372684303602 1.03597175853789 21.89487710364729 -6.666041274545634 1.9509880696138666 0.7530746138803048 1.0342586406550982 0.2618510032121879 0.16392749960839953 0.4702441840416034 3.4467354673683555 0.06772912361862879 0.1819221959194698 2.157539350852637e-07 6.666041274545634 0.28118402677479337 ASNTAEVFFDGVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASNTAEVFFDGVR 13 0 P49748-2;P49748;P49748-3 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 13027700.0 3318100.0 4280400.0 5429200.0 False True 4544891.238280902 4091277.774610067 4146934.77788385 1.0 0.9001926691116126 0.912438727456198 22.115814339679698 -10.245010502363579 6.688116173207857 1.0000008360058599 0.9063156982839052 0.9873470821043461 0.00499943238409779 6.232161065821641e-08 7.031985863872407e-09 0.004840722797500028 0.0016135598636750643 5.68839174675354e-11 10.245010502363579 -0.09368513772195464 ASNTAEVFFDGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASNTAEVFFDGVR 13 0 P49748-2;P49748;P49748-3 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 8675100.0 4027400.0 2514200.0 2133500.0 False True 3348961.5440714434 2500655.505570376 2579604.985810559 1.0 0.7466957958944629 0.7702701126494417 21.675282379081565 -9.984018308641266 5.183358460313433 1.0000012448309825 0.7584829542723034 0.9929050101886623 0.009624174519272314 1.455276648854979e-07 2.8503903439456023e-08 0.00931861744827324 0.0031061889687629602 1.0374846774424121e-10 9.984018308641266 -0.24151829055867913 ASPALVAK(ub)DPGTVANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASPALVAKDPGTVANK 16 1 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 42030400.0 15434900.0 14096000.0 12499500.0 True False 20235303.371784206 11992931.745777639 11206171.64367041 1.0 0.5926736815075576 0.5537931128473281 24.27037114255852 -13.999999999999998 0.33224014288368914 5.494352211097878 0.5470866715301473 0.9997194723682373 0.0033800173477274115 19.014230060298864 0.18444106393209206 59.7832336760555 0.012356096348693616 1.0000000000000041e-14 13.999999999999998 -4.947265539567731 ASPALVAK(ub)DPGTVANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASPALVAKDPGTVANK 16 1 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 77988800.0 18154300.0 26040000.0 33794500.0 True False 17578001.683661427 36437907.79680603 24942706.63673157 1.0 2.0729266302593823 1.418972821007041 24.067267734412017 -10.188192804336264 5.779595429822608 0.9999952418114922 1.7459497252891305 0.6343501810461094 0.26697552473725306 5.2163485719434856e-05 7.326787987067704e-06 0.2585031836546561 0.08616598008584124 6.483465372456901e-11 10.188192804336264 0.7459544834776383 ASPALVAK(ub)DPGTVANK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASPALVAKDPGTVANK 16 1 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 174015900.0 31736700.0 95963000.0 46316200.0 True False 48146894.16355698 78837652.8876589 37161782.76888835 1.0 1.6374400521006431 0.7718417441974189 25.520939400611468 -6.709409097279761 1.7976329400754059 1.3921250358661803 0.7739380189636322 0.46217702920218495 0.26863854197043774 0.37624962929421657 2.369786480139507 0.11894844790060326 0.3023653184880191 1.9524993713568021e-07 6.709409097279761 -0.6181870169025481 ASPALVAK(ub)DPGTVANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASPALVAKDPGTVANK 16 1 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 46661800.0 15434900.0 11744200.0 19482700.0 True False 21141599.64248872 11225302.411124071 14881287.518801617 1.0 0.5309580448474837 0.7038865445590208 24.333581204081412 -10.228518552426937 4.96813491578727 1.0000562205231014 0.6174222947028717 0.8671267170966853 0.07059776438104041 99534919.66824022 6.650593680878581 64014.80943230924 0.02416749253788066 5.90855724540745e-11 10.228518552426937 -0.3826339258202297 ASPALVAK(ub)DPGTVANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASPALVAKDPGTVANK 16 1 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 61600500.0 18154300.0 28772600.0 14673600.0 True False 15096104.821854373 28617596.292886067 17741781.916939203 1.0 1.8956940635081483 1.1752556123785474 23.847673009846293 -10.251690616530471 4.786500153534961 0.9998597328124432 1.535474837944408 0.4241573138297111 0.2941177660617409 0.0004403620514884786 6.88450366295866e-05 0.2848522035281021 0.09492610081455277 5.6015650467201556e-11 10.251690616530471 0.5356151051319649 ASPALVAK(ub)DPGTVANK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASPALVAKDPGTVANK 16 1 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 115879700.0 31736700.0 53224000.0 30919000.0 True False 41083783.77388392 50262037.61234381 25292059.255730726 1.0 1.2234033235345356 0.615621467461046 25.292065722703917 -6.807223225629847 1.4263214731807292 1.122156664433329 0.6056642651924755 0.852422258507186 0.09642766406874902 0.21060771499501335 0.8449831583906285 0.05316876157271435 0.1231438594991988 1.5587511050420397e-07 6.807223225629847 -0.5164923992408534 ASPALVAK(ub)DPGTVANKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASPALVAKDPGTVANKK 17 2 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 21010400.0 5065400.0 5040000.0 10905000.0 True False 4904601.649659783 7052498.283252781 8048653.357012464 1.0 1.4379349816803149 1.6410411959900504 22.22570453524919 -11.198749345585263 0.1408402689823377 3.1445010315794687e-20 1.9389702267340185 0.9996877492204777 0.004726765049887593 3.637809602290455 0.08593750868848328 1.364823205180534 0.2109915367636963 6.3277695519891965e-12 11.198749345585263 1.9389702267340185 ASPALVAK(ub)DPGTVANKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASPALVAKDPGTVANKK 17 2 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 71737000.0 19352000.0 28388000.0 23997000.0 True False 29358398.820707716 23321939.60354367 19253982.431741267 1.0 0.7943873147160098 0.6558253585056083 24.80726995131581 -8.009897118540666 0.07643313839717346 1.5907679902622125 2.4389598776903483e-11 0.9999966007535895 0.000260626127303585 0.10773144142474789 0.012559085077976023 0.12108951223710383 0.1329663503758367 9.774687493429224e-09 8.009897118540666 -1.590767990237823 ASPALVAK(ub)DPGTVANKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASPALVAKDPGTVANKK 17 2 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 17210100.0 5065400.0 7922200.0 4222500.0 True False 4212104.535268291 7879521.536166424 5105405.227365876 1.0 1.8706851812889624 1.2120794212531778 22.006109810683466 -10.276076929536456 4.757019441853341 0.9998051149373296 1.541382301271949 0.47394442684217286 0.26887467562755263 0.0005559409668061449 8.460273744046567e-05 0.2604292882779406 0.08677892840973583 5.295696293113405e-11 10.276076929536456 0.5415771863346194 ASPALVAK(ub)DPGTVANKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASPALVAKDPGTVANKK 17 2 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 60013000.0 19352000.0 26898000.0 13763000.0 True False 25051545.48494965 25401102.654757723 11258275.220305376 1.0 1.0139535171599725 0.44940441806550696 24.57839627340826 -6.901233066205762 0.95343342707358 1.0226843615962844 0.3886375644103272 0.987170027571233 0.02977897804953586 0.11050354245269212 0.1723424315026958 0.02336964996663492 0.06118919571908616 1.2553560900571771e-07 6.901233066205762 -0.6340467971859571 down ASPALVAK(ub)DPGTVANKKEEEDLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASPALVAKDPGTVANKKEEEDLAK 24 3 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 111783000.0 15401000.0 43135000.0 53247000.0 True False 23364442.963916875 35437222.234706745 42722707.11101082 1.0 1.5167159041383778 1.8285352309485865 24.477811306260197 -9.33517217028319 0.11705575677228088 7.239329153157638e-22 2.567967587050208 0.9999163176421352 0.0031256025741398467 0.7932267813497005 0.04392736178645789 0.5959969379562924 0.3397798497290537 4.6219775290984497e-10 9.33517217028319 2.567967587050208 ASPALVAK(ub)DPGTVANKKEEEDLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASPALVAKDPGTVANKKEEEDLAK 24 3 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 115324000.0 15401000.0 47162000.0 52761000.0 True False 19936898.099096186 44537393.24127013 43159039.373576365 1.0 2.2339178853148263 2.1647820618360347 24.248937628352646 -10.307750919373195 5.781895822145236 0.9998807567339589 2.199349973575437 0.9975140366730582 0.028224581745050353 4.338858919998311e-05 5.194802673936409e-06 0.02733098117831135 0.009109444587684205 4.9232181573094316e-11 10.307750919373195 1.199469216841478 ASPDQNASTHTPQSSVK(ub)TSVPSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASPDQNASTHTPQSSVKTSVPSSK 24 1 Q14677;H0YD52;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 58349000.0 29442000.0 18518000.0 10389000.0 True False 38598747.116733566 15755186.582598658 9314045.938324898 1.0 0.4081787042193495 0.24130435918442067 25.202050683782343 -13.999999999999996 0.17757985816427513 4.048393825650445 0.10538193092284767 0.9995012571700647 0.00726987695140025 12.174387463885518 0.1335630243255926 12.798480676247665 0.12720520168376284 1.0000000000000082e-14 13.999999999999996 -3.943011894727597 ASPDQNASTHTPQSSVK(ub)TSVPSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASPDQNASTHTPQSSVKTSVPSSK 24 1 Q14677;H0YD52;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 116219000.0 55562000.0 36162000.0 24495000.0 True False 53798214.723101094 50601675.182338715 18079024.665751524 1.0 0.9405827952244338 0.33605250209145593 25.681054962404893 -6.925915808376594 0.7795910914526898 1.0107170547765338 0.22393901928683405 0.9956727519629641 0.019732274287703883 0.09481477596155975 0.08848203052903526 0.017557978029575344 0.05597816274817942 1.1859986416548579e-07 6.925915808376594 -0.7867780354896998 down ASPDQNASTHTPQSSVK(ub)TSVPSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASPDQNASTHTPQSSVKTSVPSSK 24 1 Q14677;H0YD52;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 163981000.0 71557000.0 22105000.0 70319000.0 True False 108557200.51743382 18160190.042846713 56420418.82808746 1.0 0.16728683087152993 0.5197298618531212 26.69388018110232 -10.608827857818058 6.457604374014565 1.0019552138845715 0.34350834644570793 0.8222584220254026 0.14388426488413694 0.004058862459208805 0.00024586682226025784 0.13961189666365578 0.04643844680646324 2.4613430183304583e-11 10.608827857818058 -0.6584468674388636 ASPDQNASTHTPQSSVK(ub)TSVPSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASPDQNASTHTPQSSVKTSVPSSK 24 1 Q14677;H0YD52;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 115899000.0 55562000.0 41485000.0 18852000.0 True False 46202264.81394881 41261512.0708722 22793866.038200468 1.0 0.8930625422157886 0.49334953881565624 25.46146023783917 -6.946433702478803 0.5967153535766553 1.004536685770617 0.3615290934086144 0.9988908528850055 0.007261807491328133 0.08495022138532898 0.042138529136509346 0.007477439114300901 0.03355539508191211 1.1312700709594377e-07 6.946433702478803 -0.6430075923620027 down ASPDQNASTHTPQSSVK(ub)TSVPSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASPDQNASTHTPQSSVKTSVPSSK 24 1 Q14677;H0YD52;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 145787000.0 71557000.0 26275000.0 47955000.0 True False 92631947.0993458 24812773.152418718 39227682.05985209 1.0 0.26786410012312 0.4234789755394134 26.46500650319477 -10.210024201638898 8.036085425540016 1.000000293415334 0.3456715378537673 0.9593061220486262 0.06352950685944879 3.339625667115021e-07 3.284956096243617e-08 0.061512208011115364 0.02050406017161792 6.16560642240488e-11 10.210024201638898 -0.6543287555615667 ASPLTFTVQLSNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASPLTFTVQLSNK 13 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 29270800.0 7385700.0 7650100.0 14235000.0 False True 11204646.866995709 6284879.884495888 11421446.010577857 1.0 0.5609172657648466 1.0193490384976567 23.41759384485259 -10.983146883587077 11.777751224423483 1.1328776770218205 0.7901331521312522 0.21840350308215006 0.1871539875124879 0.07688781823573632 0.00011002088718703119 0.02133669873232825 0.060403689734348 1.0395685118637414e-11 10.983146883587077 -0.3427445248905683 ASPLTFTVQLSNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASPLTFTVQLSNK 13 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 20941600.0 7385700.0 7225000.0 6330900.0 False True 9560934.243912393 6822922.398714568 5178741.1605196055 1.0 0.7136250730998215 0.5416563934447093 23.18872016694504 -10.172329341459276 0.09064048057785351 1.841081957045868 3.1752946675617086e-14 0.9999468810677079 0.0013778436662933483 1.8691957441678526 0.04473745751064926 0.6458887416295057 0.29426910559194236 6.724665068212925e-11 10.172329341459276 -1.8410819570458363 ASPSKPASAPASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASPSKPASAPASR 13 1 P27816-6;P27816;E7EVA0;P27816-2;P27816-5;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 6159380.0 2057340.0 881340.0 3220700.0 False True 1992030.8678309822 1233263.6581273833 2377102.051071073 1.0 0.6190986686216461 1.1933058314800988 20.925808572413725 -6.72786990905005 1.731167173535717 0.7702319162334156 1.1928230620422622 0.5493015817878508 0.16015020104533273 0.3402386169663504 1.9966726945528022 0.07334311583111057 0.182424676760611 1.8712425786835648e-07 6.72786990905005 0.4225911458088466 ASSAAGLTAAVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASSAAGLTAAVVR 13 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 34953700.0 8804700.0 12037000.0 14112000.0 False True 11543046.964836085 10241126.519858502 12651825.611862635 1.0 0.8872117172403733 1.096055976416301 23.46052076001753 -6.7600305304895985 1.612425536180538 0.934488922460311 1.0968184030606167 0.6910769207898161 0.047439075539462146 0.28286029190099654 1.449448101691262 0.023213629301122387 0.05578275464572093 1.7376786672955907e-07 6.7600305304895985 0.16232948060030572 ASSAAGLTAAVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASSAAGLTAAVVR 13 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 24367100.0 5867500.0 2609600.0 15890000.0 False True 5681239.424207127 3651626.8888842203 11727932.310218075 1.0 0.642751804003374 2.064326361646838 22.437774273014526 -6.840134454281676 1.2818181967922546 0.8099588206625586 2.1111939035422003 0.9246782590575787 0.16571480117527185 0.16864139392899602 0.5381950826660898 0.1013724829703553 0.23354471600139634 1.444992342806302e-07 6.840134454281676 1.3012350828796415 up ASSAAGLTAAVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASSAAGLTAAVVR 13 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 71058400.0 6123600.0 58119000.0 6815800.0 False True 9289948.895126382 47747210.364180446 5468654.1425287295 1.0 5.139663404308844 0.5886635334880745 23.14723922955422 -6.667287741985132 1.946766498454486 3.648510889751495 0.6072013178076593 0.2670674848872421 1.759556224535637 0.4674488009573391 3.412721402898991 0.7282757317758712 1.952835168138524 2.1513558807151125e-07 6.667287741985132 -3.041309571943836 ASSAAGLTAAVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASSAAGLTAAVVR 13 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 28519000.0 8804700.0 7710300.0 12004000.0 False True 12060035.528070834 7369633.451447524 9168902.430140303 1.0 0.6110789171635548 0.7602715936282979 23.523730821540422 -10.30210702229127 4.919226105104992 1.0001159530937525 0.6856752553957808 0.8554569274192247 0.06090765511706757 7.748456254195617e-05 1.0992714242700991e-05 0.058995235288942224 0.019657861160325536 4.987615635337789e-11 10.30210702229127 -0.31444069769797167 ASSAAGLTAAVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASSAAGLTAAVVR 13 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 14229400.0 5867500.0 4797800.0 3564100.0 False True 4879086.224323193 4771953.299111263 4309336.831463517 1.0 0.9780424201814981 0.8832262094448414 22.218179548448802 -6.9431236429829095 0.6298678989633676 1.0010342844651279 0.8551257334709239 0.9985446879262667 0.0019330340676084754 0.08637088730204509 0.04834074966029163 0.0019295543176353145 0.008055142520470274 1.1399252063753035e-07 6.9431236429829095 -0.14590855099420397 ASSAAGLTAAVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASSAAGLTAAVVR 13 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 20455900.0 6123600.0 8427400.0 5904900.0 False True 7927120.914202029 7958407.78172002 4830268.7893904885 1.0 1.0039468134593403 0.6093345669468345 22.91836555164667 -6.90464029672061 0.9314545194068254 1.0143838254946305 0.5637761939355547 0.9887371476849015 0.019643896277310585 0.10807014059874298 0.15877823965979893 0.015668155222180808 0.041802440452638624 1.2455458047565864e-07 6.90464029672061 -0.4506076315590758 ASSELFSQK(ub)TK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASSELFSQKTK 11 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 4769200.0 1221800.0 1294900.0 2252500.0 True False 1601791.631928032 1101705.9674806665 2019432.9075057076 1.0 0.6877960563163722 1.2607338353209976 20.611255057185843 -6.758676076795793 1.617040117926858 0.8183680083379172 1.2627251529212629 0.6857759961760506 0.13129097837943982 0.2851073181012103 1.4689424719461381 0.06406579088712502 0.1541875192270877 1.7431065033686106e-07 6.758676076795793 0.44435714458334563 ASSELFSQK(ub)TK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASSELFSQKTK 11 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 8466000.0 1627600.0 2018100.0 4820300.0 True False 1575932.7289031977 2823937.854252473 3557718.8240996967 1.0 1.7919152273827383 2.2575321641906396 20.58777452179034 -9.05152827062042 0.1548182651554952 4.522093011250833e-22 3.0078603392290404 0.9998139909627348 0.007079943462349321 0.5205434545270842 0.05196211657015967 0.5859098756881701 0.3436502210243052 8.881201618034185e-10 9.05152827062042 3.0078603392290404 ASSELFSQK(ub)TK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASSELFSQKTK 11 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 4830300.0 1221800.0 1265300.0 2343200.0 True False 1673532.4779035018 1209394.8622124356 1789784.4197188257 1.0 0.7226599293295406 1.0694650049223766 20.674465118708735 -6.693740551010064 1.852814925552384 0.8267335274689477 1.0683306747644792 0.3879639570252862 0.11720896742818364 0.4087690805425448 2.7234342174738577 0.05054922509065127 0.13103142439200446 2.0242280982369365e-07 6.693740551010064 0.2415971472955315 ASSELFSQK(ub)TK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASSELFSQKTK 11 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 7072800.0 1627600.0 2575900.0 2869300.0 True False 1353421.5149055684 2562023.115423883 3469257.363855745 1.0 1.8929971832187413 2.563323639862341 20.368179797224617 -7.332606751320773 0.1389096153632947 2.2246116494050482e-14 4.2336122011478245 0.9999949560412446 0.001438199220230476 0.11548325508208804 0.008914172191929165 0.09136084380636698 0.16683340357061088 4.649360789719332e-08 7.332606751320773 4.233612201147802 ASSMREDLVEK(ub)NER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASSMREDLVEKNER 14 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 7412400.0 1665900.0 3180200.0 2566300.0 True False 2156540.3897983483 3003219.0743795224 2099259.732461649 1.0 1.3926097042218368 0.9734386345798719 21.04028730585386 -6.660836780619244 1.9692874002081229 1.2525281401706276 0.9751585473438871 0.23949984210807007 0.16712771386536024 0.48241632845571847 3.597122000024231 0.06853457319521812 0.18536153964155597 2.183550393784404e-07 6.660836780619244 -0.27736959282674056 ASSSILIDESEPTTNIQIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASSSILIDESEPTTNIQIR 19 0 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 0 11046600.0 3603000.0 2491000.0 4952600.0 False True 3488624.7371824854 3485669.2903933953 3655365.4851847696 1.0 0.999152833276222 1.0477955528507055 21.73422698803078 -6.902936886458921 0.942504515568161 0.9981373335750006 1.0532174045397324 0.9879718526824961 0.0024932260338621634 0.10927602621961743 0.16547446972816318 0.0019724839449776982 0.0052120405655454475 1.250440736437518e-07 6.902936886458921 0.055080070964731886 ASSSILIDESEPTTNIQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASSSILIDESEPTTNIQIR 19 0 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 0 33965800.0 5007300.0 22302000.0 6656500.0 False True 7596440.182664828 18322033.853678662 5340839.857352402 1.0 2.4119236659678798 0.7030714030422125 22.856892075515642 -6.687266121888539 1.8756597124894212 1.8874726444861025 0.7091083136258927 0.35765732384483095 0.5974868905598678 0.4226940310508811 2.8808776878510782 0.25500855912413223 0.6664728988650754 2.054631197311274e-07 6.687266121888539 -1.1783643308602099 ASSVIFGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASSVIFGLK 9 0 Q9H0C8;F8SNU6 Q9H0C8 ILKAP;ILKAP2 Integrin-linked kinase-associated serine/threonine phosphatase 2C 0 18607300.0 4725700.0 5416100.0 8465500.0 False True 6195438.463743895 4608038.991792445 7589571.266810029 1.0 0.7437793174379805 1.2250256880485035 22.562774957756925 -6.762059270167844 1.6045922668237143 0.8515534865461112 1.2269724522043053 0.6993503377898399 0.10780182794092008 0.2794795074848923 1.418647495813313 0.05299513673236032 0.12710449627903223 1.72958029931932e-07 6.762059270167844 0.3754189656581941 ASSVIFGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASSVIFGLK 9 0 Q9H0C8;F8SNU6 Q9H0C8 ILKAP;ILKAP2 Integrin-linked kinase-associated serine/threonine phosphatase 2C 0 14088500.0 3301700.0 1278500.0 9508300.0 False True 3196889.340759204 1789011.7172894229 7017790.987114314 1.0 0.5596101480524079 2.195193589480865 21.608237375907116 -6.835017637738012 1.3052270631892862 0.7653620858141891 2.2439267366462885 0.9155528908488672 0.20080860623895694 0.1747067674719537 0.5802760746361787 0.12072356886118348 0.27787711400935755 1.462117793149044e-07 6.835017637738012 1.4785646508320993 up ASSVIFGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASSVIFGLK 9 0 Q9H0C8;F8SNU6 Q9H0C8 ILKAP;ILKAP2 Integrin-linked kinase-associated serine/threonine phosphatase 2C 0 12455700.0 4725700.0 4043200.0 3686800.0 False True 6472918.997240602 3864558.054925569 2816053.7720294343 1.0 0.5970348240991469 0.4350516008666129 22.625985019279817 -13.999999999999918 0.1256072542391153 2.9154023961139464 0.19502199493799202 0.9996659315152089 0.004341467540146193 11.945751684889741 0.10975547059049834 5.673442630698846 0.2131800663671381 1.0000000000001882e-14 13.999999999999918 -2.7203804011759543 ASSVIFGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASSVIFGLK 9 0 Q9H0C8;F8SNU6 Q9H0C8 ILKAP;ILKAP2 Integrin-linked kinase-associated serine/threonine phosphatase 2C 0 7328100.0 3301700.0 1768600.0 2257800.0 False True 2745509.8401104133 1759072.2007603873 2729895.541112297 1.0 0.6407087583738708 0.9943127870933116 21.388642651341392 -10.850406906325414 10.09482429374056 1.0056379502074515 0.8175107727335912 0.26205960222604796 0.14435824022584645 0.018565333845897147 0.0002751153021476702 0.14166622045732896 0.04659142169020939 1.4112147065299157e-11 10.850406906325414 -0.18812717747386032 ASSVVVSGTPIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASSVVVSGTPIR 12 0 P16930;P16930-2 P16930 FAH Fumarylacetoacetase 0 16209700.0 5219900.0 5932700.0 5057100.0 False True 6843339.449583504 5047564.285483471 4533839.803128577 1.0 0.7375878871229562 0.6625186192399842 22.70626908034944 -13.999999999999996 0.17551625400716553 2.3435443554956894 0.6000431681654462 0.9995042361212694 0.003221391311531922 12.150019242496883 0.1327593582038027 5.5619391696338605 0.05826072056487158 1.0000000000000082e-14 13.999999999999996 -1.743501187330243 ASSVVVSGTPIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASSVVVSGTPIR 12 0 P16930;P16930-2 P16930 FAH Fumarylacetoacetase 0 10109700.0 4413800.0 1065300.0 4630600.0 False True 4273686.334991974 1490679.8454661097 3417706.944977703 1.0 0.3488042239461426 0.7997093555964307 22.027049595347748 -10.363441157758901 5.806128442195324 1.0000857443142672 0.5742567897714771 0.5431029691992395 0.18408124915761656 0.00020435736478385924 2.2404972302077316e-05 0.178271562689307 0.05941196769470841 4.330707402004024e-11 10.363441157758901 -0.42582895454279013 ASSVVVSGTPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASSVVVSGTPIR 12 0 P16930;P16930-2 P16930 FAH Fumarylacetoacetase 0 18861900.0 5219900.0 5382800.0 8259200.0 False True 7149838.092493435 5144970.097460763 6308547.063563378 1.0 0.7195925321529211 0.8823342545597888 22.76947914187233 -10.211669956490379 5.20314396319969 1.0000157448196927 0.8009633937074276 0.6660404993529125 0.0664390299600008 1.213561372701691e-05 1.8387339811773657e-06 0.06433440029665762 0.021443104714401886 6.142286128823045e-11 10.211669956490379 -0.19905235111226505 ASSVVVSGTPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASSVVVSGTPIR 12 0 P16930;P16930-2 P16930 FAH Fumarylacetoacetase 0 7530460.0 4413800.0 2149200.0 967460.0 False True 3670270.264493856 2137621.8330172026 1169751.412970369 1.0 0.5824153751554829 0.3187098847424202 21.807454870782024 -8.51369379457859 0.1947674484772137 1.327329062838848 1.0931769309356655e-21 0.9997331872786897 0.004581639417039797 0.16296734614968014 0.049682623763785835 0.15471533484286867 0.12855515907276804 3.0641230752490237e-09 8.51369379457859 -1.327329062838848 down ASTK(ub)VEVDMEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASTKVEVDMEK 11 1 I3L0N3;P46459;P46459-2 I3L0N3 NSF Vesicle-fusing ATPase 1 2868040.0 881550.0 1245000.0 741490.0 True False 853565.6777860731 1742134.9925892323 547271.5247768153 1.0 2.041008721329888 0.641159244120845 19.703142640426528 -6.707583257272119 1.8039249554079628 1.6415649096448586 0.6446906531700982 0.45358208286131196 0.43884468229534596 0.3799470372362252 2.4086461674774364 0.19370990824915887 0.4935423774787068 1.9607252547783273e-07 6.707583257272119 -0.9968742564747604 ASTK(ub)VEVDMEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASTKVEVDMEK 11 1 I3L0N3;P46459;P46459-2 I3L0N3 NSF Vesicle-fusing ATPase 1 11383300.0 4276300.0 3034700.0 4072300.0 True False 6487459.739406377 2493134.074780679 3267408.1200475 1.0 0.3843005081999643 0.5036498492931654 22.62922224958637 -10.38763158799442 7.039559956300072 1.0000271825394804 0.44397517874755865 0.9665990122959105 0.0487241644692878 2.078757801215388e-05 1.8082960596000978e-06 0.04717926673023306 0.015725656462285232 4.0960798284070613e-11 10.38763158799442 -0.5560520037919218 ASTLAK(ub)FALSSNSQDEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASTLAKFALSSNSQDEVR 18 1 P04035-2;P04035;P04035-3 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 74349900.0 4840600.0 8412300.0 61097000.0 True False 6346073.476437075 7157217.630888564 54775268.52380749 1.0 1.1278182733722295 8.631363744398433 22.597432794562977 -6.9105968754480696 0.8916520165703856 0.7720343947558688 9.613580497843769 0.9911449721819108 0.33572601075759595 0.10402511600843811 0.13663336537159282 0.2756764173333007 0.7641839841839733 1.228579104287329e-07 6.9105968754480696 8.8415461030879 up ASTLAK(ub)FALSSNSQDEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASTLAKFALSSNSQDEVR 18 1 P04035-2;P04035;P04035-3 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 95692500.0 5734500.0 11606000.0 78352000.0 True False 5552461.436406595 16240336.324490461 57829260.69038417 1.0 2.924889530615232 10.415067507035173 22.404696037159795 -6.945508427225046 0.6061540752642461 0.9166459260273934 12.810809235805635 0.998799988348083 0.14069015752794137 0.0853410547252945 0.04382431223211316 0.1435338741116662 0.6307495661598815 1.1336828394535506e-07 6.945508427225046 11.894163309778243 ASTLAK(ub)FALSSNSQDEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASTLAKFALSSNSQDEVR 18 1 P04035-2;P04035;P04035-3 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 616833100.0 6853100.0 319910000.0 290070000.0 True False 10396653.728720138 262819561.03176162 232737537.35780263 1.0 25.27924540813918 22.385812149814996 23.3096159208652 -9.95808535332352 12.254119389300094 0.9999999665612765 23.832528736603315 0.9880990763900744 1.1812391812821335 0.0 0.0 1.143729919248347 0.3812433064161156 1.1013228416687014e-10 9.95808535332352 22.83252877004204 ASTLAK(ub)FALSSNSQDEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASTLAKFALSSNSQDEVR 18 1 P04035-2;P04035;P04035-3 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 68809100.0 4840600.0 4444500.0 59524000.0 True False 6630300.632296346 4248127.29400393 45465657.135260895 1.0 0.6407141289055891 6.857254241805664 22.660642856085868 -6.893194749016205 1.003308388017467 0.6911073376103228 7.426605059311277 0.9828650328513102 0.3730141032337153 0.11658871713874662 0.2070203172725279 0.2820291278913158 0.711679902891795 1.2788077246981405e-07 6.893194749016205 6.735497721700955 up ASTLAK(ub)FALSSNSQDEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASTLAKFALSSNSQDEVR 18 1 P04035-2;P04035;P04035-3 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 84621500.0 5734500.0 13461000.0 65426000.0 True False 4768490.831424165 13388482.921200715 79106274.10435522 1.0 2.8076981574487143 16.58937322119779 22.18510131259407 -6.93100401831932 0.7385089741897851 0.7980343762882326 19.4923593919086 0.9967318373573506 0.398005237664497 0.09211990075819249 0.07515194311041754 0.36479109875409754 1.2401913657709596 1.172184519834704e-07 6.93100401831932 18.694325015620368 ASTLAK(ub)FALSSNSQDEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASTLAKFALSSNSQDEVR 18 1 P04035-2;P04035;P04035-3 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 403783100.0 6853100.0 188830000.0 208100000.0 True False 8871473.044796843 178321444.50508964 170227935.28631482 1.0 20.100545152383226 19.18823789766844 23.080742242957648 -9.623368731768188 8.858142931881119 0.9999985316063302 19.64439152354807 0.9982074639257346 0.3724478771160883 0.0 0.0 0.3606211063497783 0.12020703544992607 2.3802976521354747e-10 9.623368731768188 18.64439299194174 ASTNAMLISAGLPPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASTNAMLISAGLPPLK 16 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 18146800.0 5853400.0 5413500.0 6879900.0 False True 7673864.0844062315 4605826.901657728 6168033.944660831 1.0 0.6001965699414789 0.8037715910547151 22.87152178220734 -10.275590466205829 4.769598002425664 1.0001044944877686 0.7019840804976358 0.7407569822138242 0.08310915435232825 9.238075126634765e-05 1.4030763301979678e-05 0.08049820048552715 0.026823364226753736 5.3016314488947164e-11 10.275590466205829 -0.2981204139901328 ASTNAMLISAGLPPLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASTNAMLISAGLPPLK 16 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 10679000.0 3434900.0 1765800.0 5478300.0 False True 3325860.9796692007 2470893.1485253526 4043368.8845228218 1.0 0.7429333828532768 1.2157359881365175 21.66529643484246 -6.759071947932054 1.616140043062608 0.8505078442780754 1.2173739436534627 0.6871003440621275 0.10810833839121409 0.2844790011410127 1.4642648845804624 0.05278634476217117 0.1269614814737302 1.7415183387042618e-07 6.759071947932054 0.3668660993753874 ASTNAMLISAGLPPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASTNAMLISAGLPPLK 16 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 17328100.0 5853400.0 5884500.0 5590200.0 False True 8017560.162187222 5624503.332560719 4269909.893782935 1.0 0.7015230592328143 0.532569735356758 22.93473184373023 -11.866767036636732 0.0832494046837264 2.1803772296536486 1.516416125492023e-06 0.9999229988655007 0.0016958016144412269 5.343183923701458 0.060640483760373495 1.5213482581387436 0.3865888771831079 1.3590422657837454e-12 11.866767036636732 -2.180375713237523 ASTNAMLISAGLPPLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASTNAMLISAGLPPLK 16 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 7267500.0 3434900.0 1804100.0 2028500.0 False True 2856271.5418709354 1794380.9552141859 2452649.971275705 1.0 0.6282249180128083 0.8586893561489439 21.445701710276737 -10.415393481830266 5.811104184722174 1.0001027899258654 0.7434571370808759 0.6229481189179525 0.09408671288179303 0.00012534661548672672 1.2610065797351943e-05 0.0911353960295436 0.030366356007548452 3.8424348992802234e-11 10.415393481830266 -0.2566456528449895 ASTSK(ub)ATRPWYSHPVYAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASTSKATRPWYSHPVYAR 18 2 H7BYE2;Q9NWZ8 H7BYE2 GEMIN8 Gem-associated protein 8 1 24777700.0 6984200.0 7495500.0 10298000.0 True False 10595542.013413943 6157869.462391197 8262595.786226251 1.0 0.5811755033008544 0.7798181325472369 23.336954054664755 -10.076314228080347 4.88863826452049 1.0000097453550592 0.6804968179213658 0.7752508527854948 0.08109551381230966 8.616101376562662e-06 1.6278483938024475e-06 0.07852278893476855 0.02617346453595203 8.38852825926475e-11 10.076314228080347 -0.3195129274336933 ASTSK(ub)ATRPWYSHPVYAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASTSKATRPWYSHPVYAR 18 2 H7BYE2;Q9NWZ8 H7BYE2 GEMIN8 Gem-associated protein 8 1 32763200.0 6984200.0 14721000.0 11058000.0 True False 9041184.579164179 13901763.409200989 9045557.46466154 1.0 1.5376042030198382 1.0004836628938467 23.108080376757204 -10.707222207249298 2.701634807558157 0.9565179647611773 1.2690439316794215 0.2506753011955343 0.21927855008775937 41137835.77560098 33374588.261913437 12116297.926126502 0.07939325904456501 1.9623559783382448e-11 10.707222207249298 0.3125259669182442 ASTSSSSSSSSNQQTEK(ub)ETNTPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASTSSSSSSSSNQQTEKETNTPK 23 1 C9J2P0;P51965;P51965-3 C9J2P0 UBE2E1 Ubiquitin-conjugating enzyme E2 E1 1 42306200.0 13931000.0 18744000.0 9631200.0 True False 18263675.907995917 15947468.263539726 8634655.81299401 1.0 0.8731795474183734 0.4727775425106904 24.12247382824752 -6.950297139442605 0.5555752303748532 1.0053631118232895 0.321603007982425 0.999224372777329 0.006257621510396682 0.08336671223083877 0.035470746370761766 0.006744238635250871 0.0332531654073965 1.1212510443414269e-07 6.950297139442605 -0.6837601038408645 down ASTSSSSSSSSNQQTEK(ub)ETNTPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASTSSSSSSSSNQQTEKETNTPK 23 1 C9J2P0;P51965;P51965-3 C9J2P0 UBE2E1 Ubiquitin-conjugating enzyme E2 E1 1 45422000.0 17984000.0 15457000.0 11981000.0 True False 17413107.763943907 21629060.707190137 8842816.677704386 1.0 1.2421137570845284 0.5078253002037111 24.053670371824918 -6.817840103957979 1.3810409832564732 1.1307914043646667 0.4925050975804612 0.8793820595782064 0.10610437019200557 0.19629858160897068 0.7362189789787086 0.06038128419287844 0.139265974356177 1.5211074592373629e-07 6.817840103957979 -0.6382863067842055 ASTSSSSSSSSNQQTEK(ub)ETNTPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASTSSSSSSSSNQQTEKETNTPK 23 1 C9J2P0;P51965;P51965-3 C9J2P0 UBE2E1 Ubiquitin-conjugating enzyme E2 E1 1 84697000.0 41521000.0 22529000.0 20647000.0 True False 62990392.59170125 18508523.930119593 16566111.400098408 1.0 0.29383090291388375 0.26299425544905924 25.908628467153083 ASTSSSSSSSSNQQTEK(ub)ETNTPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASTSSSSSSSSNQQTEKETNTPK 23 1 C9J2P0;P51965;P51965-3 C9J2P0 UBE2E1 Ubiquitin-conjugating enzyme E2 E1 1 43120000.0 13931000.0 18459000.0 10730000.0 True False 19081667.171119396 17643420.344249874 8195794.991286707 1.0 0.9246267732283715 0.4295114739078595 24.185683889770413 -6.93394946392169 0.7136273068521033 1.0065389873028825 0.31682639567711013 0.9972591515263202 0.013247594525169047 0.09063830495459639 0.06800940376285483 0.012366442168943843 0.04386725237570821 1.1642614992118054e-07 6.93394946392169 -0.6897125916257724 down ASTSSSSSSSSNQQTEK(ub)ETNTPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASTSSSSSSSSNQQTEKETNTPK 23 1 C9J2P0;P51965;P51965-3 C9J2P0 UBE2E1 Ubiquitin-conjugating enzyme E2 E1 1 45905800.0 17984000.0 21938000.0 5983800.0 True False 14954492.826285167 21819815.63964796 7234984.914034787 1.0 1.4590809526683362 0.48380008590582363 23.834075647259194 -6.7787040863840895 1.5409391317238859 1.2603793651370405 0.47638829403049493 0.7627761966679882 0.1940355674565714 0.25259048460446937 1.184585599115118 0.09918716193216714 0.23429298226706466 1.6645464298769025e-07 6.7787040863840895 -0.7839910711065456 down ASTSSSSSSSSNQQTEK(ub)ETNTPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASTSSSSSSSSNQQTEKETNTPK 23 1 C9J2P0;P51965;P51965-3 C9J2P0 UBE2E1 Ubiquitin-conjugating enzyme E2 E1 1 106874000.0 41521000.0 39721000.0 25632000.0 True False 53749753.001270786 37510491.43243482 20967239.00652965 1.0 0.6978728149978284 0.39008996015356445 25.679754789245532 -7.063586717369686 0.24621661012938956 1.107296227226522 2.0785815777522435e-13 0.9999855361177835 0.0009469580665084789 0.07337555117193606 0.008822200209036629 0.007710014953406238 0.029456645352861327 8.638001649233381e-08 7.063586717369686 -1.1072962272263143 down ASVCKPFLFLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASVCKPFLFLLK 12 1 Q13535;Q13535-2;Q13535-3;A0A590UJ01 Q13535 ATR Serine/threonine-protein kinase ATR 0 2537930.0 598700.0 763430.0 1175800.0 False True 820055.569259147 729699.1382745906 898100.2563611281 1.0 0.8898166973413935 1.0951699982630299 19.64536214853129 -6.760965092934081 1.608910770125785 0.9360764259045089 1.0959544790128115 0.6948797866302054 0.04634982422734375 0.2812926851260864 1.435344421037659 0.022727908781870306 0.05456522470095196 1.7339433604338405e-07 6.760965092934081 0.1598780531083026 ASVEDADTQSK(ub)VHQLYETIQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASVEDADTQSKVHQLYETIQR 21 1 Q13561;Q13561-3;Q13561-2;H0YI98 Q13561 DCTN2 Dynactin subunit 2 1 15795200.0 5302700.0 4015200.0 6477300.0 True False 5134368.691051229 5618490.298991391 4780700.815165228 1.0 1.0942903864274387 0.9311175536532049 22.291755466650244 -6.750047566198351 1.6500092284964933 1.0554405136951823 0.9307984253023324 0.6490759326340327 0.03962111971226293 0.29994239603803624 1.6067393699582548 0.01897031005754734 0.04604632953737258 1.7780846542621747e-07 6.750047566198351 -0.12464208839284996 ASVEDADTQSK(ub)VHQLYETIQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASVEDADTQSKVHQLYETIQR 21 1 Q13561;Q13561-3;Q13561-2;H0YI98 Q13561 DCTN2 Dynactin subunit 2 1 11329500.0 2270700.0 4590700.0 4468100.0 True False 3110239.1533601917 4387867.6945851855 3412826.803408025 1.0 1.4107814474152862 1.0972875830853484 21.568594086047103 -10.399330646537758 6.121207200387201 0.9999465387414548 1.2540345152502517 0.46681455327310906 0.12798333418360755 9.340180186055134e-05 9.16535779052237e-06 0.12394534021966695 0.04130644349043418 3.987212236454832e-11 10.399330646537758 0.2540879765087969 ASVEDADTQSK(ub)VHQLYETIQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASVEDADTQSKVHQLYETIQR 21 1 Q13561;Q13561-3;Q13561-2;H0YI98 Q13561 DCTN2 Dynactin subunit 2 1 14955600.0 5302700.0 4661900.0 4991000.0 True False 4409429.999440743 4636785.419385302 6034595.024223344 1.0 1.0515611813711512 1.3685657840103427 22.07216074208452 -6.935320352188748 0.7017425171199815 0.9959962904910246 1.4434405959103476 0.997484554339292 0.008172916687053621 0.08996761418445268 0.06482500637516542 0.007697622250684486 0.02789224396739022 1.1605922009055319e-07 6.935320352188748 0.447444305419323 ASVEDADTQSK(ub)VHQLYETIQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASVEDADTQSKVHQLYETIQR 21 1 Q13561;Q13561-3;Q13561-2;H0YI98 Q13561 DCTN2 Dynactin subunit 2 1 50826600.0 8200800.0 9522200.0 33103600.0 True False 10616097.261935452 8992281.199313477 27079084.471619643 1.0 0.847042088767946 2.550757006410732 23.339750157691395 -6.8849851462049925 1.0515688165107975 0.8971531195595627 2.6836797788923565 0.9774905269479391 0.11546787819265782 0.12330743408823769 0.24635936309964282 0.08416703704384713 0.206382816608624 1.3032113502901258e-07 6.8849851462049925 1.786526659332794 up ASVEK(ub)GDYYEAHQMYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASVEKGDYYEAHQMYR 16 1 Q7L5D6 Q7L5D6 GET4 Golgi to ER traffic protein 4 homolog 1 9276900.0 1403000.0 2734800.0 5139100.0 True False 1816211.1572645886 2582605.975917592 4203836.531618935 1.0 1.4219745130336483 2.3146188232597193 20.792500513048232 -6.958933535188983 0.4502200606888236 0.9712787257212 2.8007142640159697 0.9997285537870932 0.009029246849474036 0.0800844274446637 0.022556481833794058 0.01193500381844017 0.07383391169042448 1.0991740451275178e-07 6.958933535188983 1.8294355382947698 up ASVFVK(ub)LQKPNAAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASVFVKLQKPNAAIR 15 2 P50502;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P4 Hsc70-interacting protein;Putative protein FAM10A4 1 33646400.0 6820600.0 19886900.0 6938900.0 True False 6604083.786407684 27827842.878813475 5121393.9274620535 1.0 4.213732559857562 0.7754889388294474 22.654926993250097 -6.661400051930653 1.968107042425139 3.0663146712257725 0.7898712109093817 0.24143513695507057 1.3678913621036861 0.4811777252113615 3.5844342496946164 0.5612633490248874 1.5164383982039402 2.1807202080658597e-07 6.661400051930653 -2.2764434603163908 ASVFVK(ub)LQKPNAAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASVFVKLQKPNAAIR 15 2 P50502;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P4 Hsc70-interacting protein;Putative protein FAM10A4 1 21200900.0 9015800.0 5908900.0 6276200.0 True False 13677627.743268717 4854410.6285535805 5035706.319043822 1.0 0.3549161243215309 0.3681710318166895 23.705314694157558 -10.002954629066275 5.677639789145152 1.0000013940128456 0.3615435780687971 0.9996768439631427 0.005411293326261752 9.548802291401547e-08 1.6769599564735393e-08 0.005239473669098363 0.001746487411010162 9.932198051068215e-11 10.002954629066275 -0.6384578159440485 ASVFVK(ub)LQKPNAAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASVFVKLQKPNAAIR 15 2 P50502;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P4 Hsc70-interacting protein;Putative protein FAM10A4 1 17970600.0 3317700.0 9102100.0 5550800.0 True False 4544343.34747131 8699939.125380406 4239815.362314467 1.0 1.9144546219689735 0.9329874611419279 22.115640410984724 -6.6620869616171206 1.9657577774252302 1.5876137888647566 0.9370843644703936 0.2444444265849426 0.3891613523477985 0.4794862174282789 3.5640493446969828 0.15983304431155362 0.4314369737524878 2.1772737589740656e-07 6.6620869616171206 -0.650529424394363 ASVFVK(ub)LQKPNAAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASVFVKLQKPNAAIR 15 2 P50502;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P4 Hsc70-interacting protein;Putative protein FAM10A4 1 22494500.0 6820600.0 12826500.0 2847400.0 True False 5671631.103812311 12757401.09863908 3442778.175109909 1.0 2.2493354848244476 0.6070172957468567 22.435332268684373 -6.703293426640019 1.818765988814921 1.7732423287763375 0.6115241214892496 0.4334271009202231 0.5270456043594078 0.38868666945766406 2.5017969716304327 0.23096667266255377 0.5916614308209046 1.9801886794383845e-07 6.703293426640019 -1.161718207287088 ASVGMYLISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASVGMYLISK 10 0 P08243-2;P08243;P08243-3;F8WEJ5 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 24365000.0 6018800.0 6551200.0 11795000.0 False True 7890705.086142118 5573786.496377588 10574566.545629239 1.0 0.7063736935456416 1.340129485285237 22.911722789566895 -6.78070683629529 1.5329262156955215 0.8338939140407357 1.3452782992772607 0.7699384660572536 0.12421032369527255 0.24948177611425895 1.1579670293252622 0.06381400230782083 0.15049752211474732 1.6568880424424828e-07 6.78070683629529 0.5113843852365251 ASVGMYLISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASVGMYLISK 10 0 P08243-2;P08243;P08243-3;F8WEJ5 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 19154800.0 6329100.0 3231800.0 9593900.0 False True 6128186.184874178 4522274.5936143575 7080969.779169353 1.0 0.7379466708724366 1.1554756277880185 22.54702869881848 -6.737034738619947 1.697569310449131 0.8435464805974595 1.1555649098655774 0.5915572085059786 0.11011394212240369 0.32320444249997987 1.827614120660901 0.051340022367109765 0.12639540658798948 1.8321678639152765e-07 6.737034738619947 0.31201842926811785 ASVGMYLISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASVGMYLISK 10 0 P08243-2;P08243;P08243-3;F8WEJ5 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 22135600.0 6018800.0 5023800.0 11093000.0 False True 8244113.011954163 4801831.9045150075 8473061.867506376 1.0 0.5824558563853061 1.0277711932405864 22.974932851089786 -9.567666766173454 14.941694142152498 1.000001949826188 0.8051135248129528 0.20342096285761613 0.18179922499199286 0.0 0.0 0.17602634268527603 0.05867544756175866 2.7060339054894645e-10 9.567666766173454 -0.19488842501323522 ASVGMYLISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASVGMYLISK 10 0 P08243-2;P08243;P08243-3;F8WEJ5 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 11525300.0 6329100.0 2309500.0 2886700.0 False True 5262927.076670446 2297058.2651001425 3490295.623407242 1.0 0.4364602115204226 0.6631852527235381 22.327433974252756 -10.251373239805604 5.577685363257494 1.0000300454725033 0.5498227321219696 0.8401693839186719 0.09256011047657173 3.45850336773122e-05 4.641937782115291e-06 0.0896269097632656 0.029873647199899343 5.605660093283836e-11 10.251373239805604 -0.45020731335053366 ASVHTLSGHTNAVATVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASVHTLSGHTNAVATVR 17 0 O43660-2;O43660;H0YA24 O43660-2 PLRG1 Pleiotropic regulator 1 0 2085950.0 1153100.0 0.0 932850.0 False True 958853.7409914051 0.0 1127904.6219889296 1.0 0.0 1.1763051795811263 19.870951244593062 -10.761085323992347 6.18213710054008 1.0137319766721204 0.5881525897905632 0.14048358233529956 0.48022457862778223 0.0904645024199781 0.0034960832427772585 0.4627968101189147 0.1549918162887396 1.7334633981055977e-11 10.761085323992347 -0.4255793868815573 ASVILAGLGFTPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASVILAGLGFTPK 13 0 Q9NUQ8;Q9NUQ8-2 Q9NUQ8 ABCF3 ATP-binding cassette sub-family F member 3 0 18926900.0 5772200.0 7121600.0 6033100.0 False True 7567410.098064311 6059085.039779371 5408852.685581668 1.0 0.8006814697843905 0.7147561207189252 22.851368200051265 -13.999999999999869 0.11471656551990723 1.9549686709087637 0.5673163846398789 0.9997192080970422 0.0020020675835162437 11.986998544426447 0.10351728542229355 2.629879161382529 0.13084814031081204 1.0000000000003026e-14 13.999999999999869 -1.3876522862688847 ASVILAGLGFTPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASVILAGLGFTPK 13 0 Q9NUQ8;Q9NUQ8-2 Q9NUQ8 ABCF3 ATP-binding cassette sub-family F member 3 0 13844800.0 5853600.0 2938900.0 5052300.0 False True 5667780.672098649 4112418.0961610316 3728951.064248876 1.0 0.725578199665637 0.6579208476795436 22.43435250023397 -13.99999999999811 0.19665342733843585 2.5064659111037244 0.6125032931919249 0.9994871022733157 0.0033498058848197634 12.466712055229758 0.1406239527795582 7.213998441531988 0.0441809552820533 1.000000000004352e-14 13.99999999999811 -1.8939626179117997 ASVILAGLGFTPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASVILAGLGFTPK 13 0 Q9NUQ8;Q9NUQ8-2 Q9NUQ8 ABCF3 ATP-binding cassette sub-family F member 3 0 19827100.0 4042800.0 8279600.0 7504700.0 False True 6133223.168269796 6802040.691189932 6021392.755573143 1.0 1.1090482939509294 0.9817664530331772 22.548214016291436 -6.679866870992662 1.9021104760427474 1.0690027888558609 0.9822483165256979 0.323643623963889 0.04621832213820006 0.4388081559973071 3.0693215386583583 0.019497035493979614 0.051435601247918905 2.0899366836757554e-07 6.679866870992662 -0.08675447233016298 ASVILAGLGFTPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASVILAGLGFTPK 13 0 Q9NUQ8;Q9NUQ8-2 Q9NUQ8 ABCF3 ATP-binding cassette sub-family F member 3 0 25681900.0 5772200.0 8813700.0 11096000.0 False True 7906338.327839728 8424281.590991657 8475353.32929331 1.0 1.0655098784892814 1.071969472827892 22.914578261574157 -13.999999999999998 0.3275191832014784 0.29744290873596757 1.0731469577293162 0.9997096382178257 0.0005539630540911014 18.615002147769726 0.1828641433373394 8.997087843608487 0.0020892053459976192 1.0000000000000041e-14 13.999999999999998 0.7757040489933487 ASVILAGLGFTPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASVILAGLGFTPK 13 0 Q9NUQ8;Q9NUQ8-2 Q9NUQ8 ABCF3 ATP-binding cassette sub-family F member 3 0 11287100.0 5853600.0 2544600.0 2888900.0 False True 4867527.758448782 2530891.734736447 3492955.6332355873 1.0 0.5199542478917489 0.7176036391724137 22.214757775668247 -10.209810909234399 5.460367951569223 1.0000184694385539 0.6187789435320435 0.8322211492974901 0.0806900261016881 1.814340434106414e-05 2.6254855314917e-06 0.07813156244328347 0.026042593941387287 6.16863524284723e-11 10.209810909234399 -0.38123952590651033 ASVILAGLGFTPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASVILAGLGFTPK 13 0 Q9NUQ8;Q9NUQ8-2 Q9NUQ8 ABCF3 ATP-binding cassette sub-family F member 3 0 21873300.0 4042800.0 11774000.0 6056500.0 False True 5233484.295501984 11118766.549822198 4954279.144937841 1.0 2.124543788041636 0.9466502362863474 22.319340338383885 -6.656680297857311 1.9847499362310304 1.725822585516137 0.951589580882017 0.22159031644657412 0.47918714261390605 0.49234087601712595 3.724732555301369 0.19530307534674007 0.5310035899159998 2.2045487254315091e-07 6.656680297857311 -0.7742330046341201 ASVITQVFHVPLEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASVITQVFHVPLEER 15 0 A0A024R4E5;Q00341;Q00341-2;C9JIZ1;C9J5E5;C9JZI8;C9JES8;C9JHS7;C9JHZ8;C9JK79;C9JT62 A0A024R4E5 HDLBP Vigilin 0 10198700.0 2586400.0 4271300.0 3341000.0 False True 3390795.446733226 3634038.6893969993 2995305.369134997 1.0 1.0717363363508463 0.8833636284432157 21.69319232423168 -6.803539380479924 1.441788708915946 1.0394042342699243 0.8805416431965354 0.8422029304722107 0.030836545128582672 0.2157514166790302 0.8850892369370498 0.016824127400919417 0.0390389081936142 1.5720292392522943e-07 6.803539380479924 -0.15886259107338896 ASVITQVFHVPLEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASVITQVFHVPLEER 15 0 A0A024R4E5;Q00341;Q00341-2;C9JIZ1;C9J5E5;C9JZI8;C9JES8;C9JHS7;C9JHZ8;C9JK79;C9JT62 A0A024R4E5 HDLBP Vigilin 0 9268200.0 3511400.0 1460100.0 4296700.0 False True 3399932.5290431837 2043125.5443209107 3171265.3717629886 1.0 0.6009312028600436 0.9327436190786565 21.697074685986962 -10.012623178327837 6.928604272589191 1.0000000336136445 0.7668374109693499 0.39699890488245326 0.13546185167593358 7.036882263621505e-08 9.872909970538003e-09 0.13116039344120972 0.04372012463227569 9.713524091971894e-11 10.012623178327837 -0.23316262264429466 ASVITQVFHVPLEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASVITQVFHVPLEER 15 0 A0A024R4E5;Q00341;Q00341-2;C9JIZ1;C9J5E5;C9JZI8;C9JES8;C9JHS7;C9JHZ8;C9JK79;C9JT62 A0A024R4E5 HDLBP Vigilin 0 9923300.0 2586400.0 3121700.0 4215200.0 False True 3542661.9748318954 2983772.9719185703 3219656.574769033 1.0 0.8422403811360396 0.9088240982748038 21.756402385754573 -10.129294928428786 4.541895052420422 1.0000120840792255 0.8755322397475231 0.8232982669357517 0.02718268872387198 3.8034692651710425e-06 7.291264025672762e-07 0.026322446341905364 0.008773175056761316 7.425147265238186e-11 10.129294928428786 -0.12447984433170234 ASVITQVFHVPLEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ASVITQVFHVPLEER 15 0 A0A024R4E5;Q00341;Q00341-2;C9JIZ1;C9J5E5;C9JZI8;C9JES8;C9JHS7;C9JHZ8;C9JK79;C9JT62 A0A024R4E5 HDLBP Vigilin 0 6032700.0 3511400.0 1032100.0 1489200.0 False True 2919884.681395558 1026539.8724441895 1800584.8347171699 1.0 0.3515686352221126 0.6166629956963166 21.47747996142124 -10.360451437469553 5.869222235336739 1.0000909702881051 0.48411581545928906 0.8346951154972138 0.10822431947520776 0.00012884952221367443 1.4040236110317368e-05 0.10480606495966217 0.03492924891517546 4.360623214834677e-11 10.360451437469553 -0.5159751548288161 ASVK(ub)EFKEEISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASVKEFKEEISR 12 2 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 13572400.0 5794000.0 3780900.0 3997500.0 True False 8789921.598138701 3106168.8546934654 3207392.3728335076 1.0 0.35337844826183756 0.3648943095820883 23.067418866606285 -9.949824283668573 5.106636882282417 1.0000023512670757 0.35913637891522754 0.9997578868503167 0.004701330732582616 6078994.314632041 0.8878063147631491 198.64294683236852 0.0016964465967757877 1.1224725168452672e-10 9.949824283668573 -0.6408659723518482 ASVMLFMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASVMLFMK 8 0 O76003 O76003 GLRX3 Glutaredoxin-3 0 16397200.0 2901600.0 5883600.0 7612000.0 False True 4401939.335374398 4833625.611223381 6107484.863541886 1.0 1.098067293290462 1.3874532105568933 22.0697078324188 -6.951821027021964 0.538479574077699 0.9956963633003307 1.5031532579290752 0.9993365574563988 0.004236555403991064 0.08276262280147469 0.03299893208625717 0.004669520971486432 0.023959531448965923 1.117323602545697e-07 6.951821027021964 0.5074568946287444 ASVMLFMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASVMLFMK 8 0 O76003 O76003 GLRX3 Glutaredoxin-3 0 4823100.0 1048700.0 1443100.0 2331300.0 False True 1436432.73005189 1379339.0703064634 1780694.9546306331 1.0 0.9602531614944724 1.2396647036623196 20.454059000556608 -6.870842035890754 1.1295709585063505 0.9773997579213493 1.256296752841795 0.9655194513046342 0.022917559820546125 0.13605319907533628 0.32392399755885826 0.015736887119798995 0.03731488184656278 1.3463499672312674e-07 6.870842035890754 0.27889699492044573 ASVMLFMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASVMLFMK 8 0 O76003 O76003 GLRX3 Glutaredoxin-3 0 20090000.0 2901600.0 10011000.0 7177400.0 False True 3756178.3990869042 9453879.04962375 5871186.846343084 1.0 2.516887656859405 1.5630745461318667 21.84083415451125 -9.90711841529559 5.587149524718297 0.999999185422169 2.039981101498298 0.6131712589280298 0.3893925718859254 32077691.13597823 56880075.04673234 219.6831016853553 0.13329943406937833 1.2384588606940504e-10 9.90711841529559 1.0399819160761288 ASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGK 55 1 P14174 P14174 MIF Macrophage migration inhibitory factor 0 19552210600.0 8155222600.0 4750406000.0 6646582000.0 False True 12372068910.833424 3902658934.2085085 5332882154.399616 1.0 0.31544109253959957 0.43104206683895485 33.52636772306174 -9.951101807143056 5.807536711010214 1.0000005076745695 0.37324157969519944 0.9751204696839164 0.04719390013486254 3.1020927402204306e-07 5.5985264819697665e-08 0.04569533442329852 0.015231765771900666 1.1191754960307156e-10 9.951101807143056 -0.62675892797937 ASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGK 55 1 P14174 P14174 MIF Macrophage migration inhibitory factor 0 14758673700.0 8155222600.0 357830000.0 6245621100.0 False True 10557096419.170624 337916445.94215006 5108982145.284205 1.0 0.03200846449867862 0.4839381911873807 33.297494045154195 -10.520094444156754 5.442097617722916 1.0018143732491767 0.25797332784302823 0.7823474653493602 0.18449953833046934 0.004069345537296113 0.0003588507542469345 0.17898453383566038 0.05954696994473787 3.019295055868232e-11 10.520094444156754 -0.7438410454061484 ASVSITFDNSDKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ASVSITFDNSDKK 13 1 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 0 33440800.0 3955800.0 19102000.0 10383000.0 False True 5120861.080475602 18038956.907992467 8493400.538576683 1.0 3.5226413340463223 1.658588351666016 22.287954991283975 -6.568592055853169 2.3115173959208826 2.729458300256697 1.6622674417979941 0.0 1.0990616977976722 0.7344237100622298 7.3642136435890935 0.402114059365668 1.2329714130116325 2.700274680060942e-07 6.568592055853169 -1.0671908584587029 ASVSVTAEDEGTQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASVSVTAEDEGTQR 14 0 P05362;E7ESS4 P05362 ICAM1 Intercellular adhesion molecule 1 0 7683400.0 1999400.0 2668800.0 3015200.0 False True 2621232.7622171417 2270625.4429009235 2703216.0278407144 1.0 0.8662433476454564 1.0312766064903858 21.321814038208515 -6.6911357935103934 1.862618154058383 0.9162297503432556 1.0307098702432789 0.3755921518373484 0.056557101558381666 0.4142582713007116 2.7874275232499683 0.024284346124240738 0.06314219503470139 2.0364052428740464e-07 6.6911357935103934 0.11448011990002327 ASVSVTAEDEGTQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASVSVTAEDEGTQR 14 0 P05362;E7ESS4 P05362 ICAM1 Intercellular adhesion molecule 1 0 5407000.0 1999400.0 1528200.0 1879400.0 False True 2738632.211753362 1460679.0709183938 1435524.4274579878 1.0 0.5333608012969435 0.5241756893449078 21.385024099731407 ASVVTLPVYLNFTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ASVVTLPVYLNFTR 14 0 Q14204;A0A2R8Y706 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 6310200.0 1483100.0 3280400.0 1546700.0 False True 1944358.4623608293 2790977.106899051 1386662.320994044 1.0 1.4354231284648316 0.7131721582399813 20.89086278836883 -6.743457927520163 1.6738905175380765 1.2580303176018754 0.7124089156150177 0.6204198442916564 0.18293916411651232 0.31159804756264964 1.7155134423451752 0.08641143920916733 0.21125833993461843 1.805269614993963e-07 6.743457927520163 -0.5456214019868577 ASVVTLPVYLNFTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASVVTLPVYLNFTR 14 0 Q14204;A0A2R8Y706 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 10004700.0 3470600.0 2984100.0 3550000.0 False True 3360427.7027103947 4175666.691875916 2620148.5022828267 1.0 1.242599770412552 0.7797068510563442 21.680213434860956 -6.764279963248622 1.5961392750717427 1.1401640065780754 0.7776359185990703 0.7082540499877832 0.10211166412945853 0.2757971795816469 1.3856740517278952 0.05045173746674105 0.12074742925135747 1.7207589486931221e-07 6.764279963248622 -0.36252808797900504 ASVVTLPVYLNFTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ASVVTLPVYLNFTR 14 0 Q14204;A0A2R8Y706 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 15033200.0 2449200.0 6985100.0 5598900.0 False True 3715615.4605042 5738554.330164606 4492274.9609149555 1.0 1.544442472899469 1.2090258016919126 21.825169770202397 -10.135758893808788 4.504229358144027 0.9999517734477836 1.3767341371048547 0.6271511399930976 0.13693328265046795 6.632555689147373e-05 1.272647599332393e-05 0.1326020197125118 0.04419502693204783 7.315451008498222e-11 10.135758893808788 0.3767823636570711 ASVVTLPVYLNFTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ASVVTLPVYLNFTR 14 0 Q14204;A0A2R8Y706 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 17238200.0 1483100.0 7132000.0 8623100.0 False True 2031442.1492704863 6816884.657629893 6586501.378319137 1.0 3.3556873180355704 3.2422785855282283 20.95407284989172 -10.253651802675886 4.141528212299801 0.9981365120374525 3.298982951912432 0.9981782412302064 0.0462989216078741 7270741.670885371 8879770.376543373 153619.0262886369 0.01694367128770466 5.576326539470021e-11 10.253651802675886 2.3008464398749795 ASYVAWGHSTVVNPWGEVLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ASYVAWGHSTVVNPWGEVLAK 21 0 Q9NQR4 Q9NQR4 NIT2 Omega-amidase NIT2 0 7244400.0 1845700.0 1719300.0 3679400.0 False True 1787109.2637851026 2405825.4560310533 2715654.760366035 1.0 1.3462106121790829 1.519579588891096 20.769196412714177 -11.581831724047117 0.11621854798583023 4.171709639748589e-12 1.8567008626629762 0.9997963413988987 0.0030824266590505386 4.5611838752894 0.07800432892485562 1.3988871418886155 0.2426849805836903 2.619197671368263e-12 11.581831724047117 1.8567008626588044 ATAAFILANEHNVALFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATAAFILANEHNVALFK 17 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 18300100.0 4213500.0 6548400.0 7538200.0 False True 5523939.303592039 5571404.245463282 6758219.37552033 1.0 1.0085925893212435 1.2234420047167567 22.397266036840513 -6.915327999210185 0.8586755064324489 0.9944153580197616 1.2546192701953507 0.9927812625492031 0.008782284084945814 0.10099936072778215 0.12044093694104249 0.007385228678505385 0.021223472951528446 1.2152678276892852e-07 6.915327999210185 0.26020391217558914 ATAAFILANEHNVALFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATAAFILANEHNVALFK 17 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 9323600.0 2293000.0 2320800.0 4709800.0 False True 2220209.9701247443 3247507.5428121183 3476162.089028634 1.0 1.4627028913979945 1.5656906940352686 21.082264691184786 -11.852833351999577 0.2514089251307318 3.156755599784376e-08 1.6110834408101724 0.9993591845783114 0.006227679886408852 4.797065090277587 0.1446781290447707 2.5703952144585687 0.04703655283871526 1.4033520972119577e-12 11.852833351999577 1.6110834092426165 ATAAFILANEHNVALFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATAAFILANEHNVALFK 17 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 34543400.0 3996400.0 15253000.0 15294000.0 False True 6062830.975975414 12530982.977767056 12271134.196401676 1.0 2.0668534266289718 2.023994111831139 22.531560171818867 -10.109115749742108 5.114906403019372 0.9999709930000507 2.0454237692320536 0.9987410168897134 0.017497242003622713 5.78792423803376e-06 1.0080974260161801e-06 0.01694209975648043 0.005647210572717383 7.778292135448059e-11 10.109115749742108 1.045452776232003 ATAAFILANEHNVALFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATAAFILANEHNVALFK 17 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 15775300.0 4213500.0 4850200.0 6711600.0 False True 5771344.8155560605 4635902.126533438 5126458.309740896 1.0 0.8032620255226902 0.8882606175120676 22.460476098363404 -10.128629690330834 4.512024289779383 1.0000167254525858 0.8457613215137129 0.8144842317283878 0.03470052989561943 48446073.31047328 0.059590681791647275 9086.401585758265 0.011878914359572732 7.436529578524225e-11 10.128629690330834 -0.15425540393887294 ATAAFILANEHNVALFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATAAFILANEHNVALFK 17 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 7811700.0 2293000.0 2041200.0 3477500.0 False True 1906731.0971236604 2030203.6504535219 4204629.171856675 1.0 1.0647561439135922 2.2051505732504375 20.862669966619062 -6.9185865746810435 0.8351500004149774 0.9735334825157609 2.383196623195749 0.9937790832379013 0.043654666732503275 0.09901041192267272 0.109978613920546 0.03733416672455633 0.11036500494532085 1.2061836168687195e-07 6.9185865746810435 1.4096631406799882 up ATAAFILANEHNVALFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATAAFILANEHNVALFK 17 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 24469200.0 3996400.0 10513000.0 9959800.0 False True 5173418.580821242 9927942.308330268 8147218.596177978 1.0 1.919029390959175 1.5748230051171825 22.302686493911317 -10.349254457552856 5.527133577388606 0.9998109746049776 1.7469261980381876 0.8626091565287474 0.14052166858676984 0.00032739554391514233 3.854621690899545e-05 0.13609315521218712 0.045353173518148514 4.4745106123199976e-11 10.349254457552856 0.74711522343321 ATAAGVK(ub)QTESTSFLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATAAGVKQTESTSFLEK 17 1 G3V5Z7;P60900;G3V295;P60900-2;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 71848600.0 0.0 23814000.0 48034600.0 True False 0.0 19564205.64036874 38540540.25568689 0.0 ATAAGVK(ub)QTESTSFLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATAAGVKQTESTSFLEK 17 1 G3V5Z7;P60900;G3V295;P60900-2;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 54636000.0 0.0 26465000.0 28171000.0 True False 0.0 24992199.4853953 23044167.058869652 0.0 ATAAVIFLHGLGDTGHGWAEAFAGIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATAAVIFLHGLGDTGHGWAEAFAGIR 26 0 O75608;O75608-2;E5RGR0;B4DP64 O75608 LYPLA1 Acyl-protein thioesterase 1 0 121817300.0 23574300.0 44747000.0 53496000.0 False True 35763936.61218523 36761548.2400933 42922492.15187027 1.0 1.0278943461600971 1.2001612858592874 25.09200220996929 -6.935226111965091 0.7025615774718311 0.9978178592122523 1.2407458592282457 0.9974695242536656 0.0044527786485909215 0.09001323718563488 0.06504001350734274 0.00419123140704159 0.015164357080256017 1.1608440722530244e-07 6.935226111965091 0.24292800001599335 ATAAVIFLHGLGDTGHGWAEAFAGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATAAVIFLHGLGDTGHGWAEAFAGIR 26 0 O75608;O75608-2;E5RGR0;B4DP64 O75608 LYPLA1 Acyl-protein thioesterase 1 0 43374000.0 23574300.0 9788700.0 10011000.0 False True 30517396.06892556 9243950.240041157 8189100.721534349 1.0 0.3029075684951325 0.268342053268199 24.86312853206174 -13.518261047480332 0.4326756808817315 9.999999827263881 0.2677192889702444 0.9998723156104604 0.0038086359205287672 20.810051223893797 0.22071591762818946 175.20131685813925 0.008129564515663844 3.032068108599848e-14 13.518261047480332 -9.732280538293637 ATAGAYIASQTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATAGAYIASQTVK 13 0 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 0 29245800.0 10128000.0 9519000.0 9598800.0 False True 13277906.07969152 8098802.30477139 8605608.254191263 1.0 0.6099457441680854 0.6481148610738775 23.6625243164213 -10.460862096209656 10.395085824154485 1.0000009224728872 0.6290303026209815 0.9921227598046823 0.015582476725304939 3.3313681703054647e-07 1.7280770384272283e-08 0.01508770575070175 0.00502922273748089 3.460492432019088e-11 10.460862096209656 -0.3709706198519057 ATAGAYIASQTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATAGAYIASQTVK 13 0 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 0 18235000.0 5562900.0 2121100.0 10551000.0 False True 5386308.784477507 2968066.2913903743 7787376.576784815 1.0 0.551039015799442 1.4457723996861833 22.36086550786501 -6.770277111099576 1.5733279478854072 0.7425765261358238 1.450864269057784 0.7316261934225268 0.18922956842213018 0.26599068297205436 1.2994478378666967 0.09479887713198296 0.22560932906552428 1.6971603965641752e-07 6.770277111099576 0.7082877429219602 ATAGAYIASQTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATAGAYIASQTVK 13 0 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 0 33733600.0 4247500.0 23836000.0 5650100.0 False True 6443768.033844355 19582279.568481974 4533355.258473199 1.0 3.0389485570602046 0.7035255202643595 22.619473129407467 -6.675988660392516 1.916203305846462 2.2946817730839184 0.7126828266264029 0.30585295314162464 0.8649223587733647 0.44748612744543753 3.1731810188338323 0.3626609191707923 0.9614150442253148 2.1086832078000416e-07 6.675988660392516 -1.5819989464575155 ATAGAYIASQTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATAGAYIASQTVK 13 0 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 0 17148400.0 10128000.0 3541100.0 3479300.0 False True 13872595.298908705 3384642.493148233 2657560.9984327853 1.0 0.2439804823985954 0.19156912900370154 23.725734377944192 -13.738441590668273 0.38131295894774025 9.999986586479352 0.18701140510642267 0.9998038008496418 0.005173729865437137 19.690017976519947 0.20108883181052542 144.3617874050286 0.014155552383024692 1.826242348378615e-14 13.738441590668273 -9.812975181372929 ATAGAYIASQTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATAGAYIASQTVK 13 0 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 0 9480400.0 5562900.0 2379200.0 1538300.0 False True 4625797.82825521 2366382.777365777 1859951.41770442 1.0 0.5115620840390999 0.40208229731604356 22.141270783299287 -13.999999999999995 0.21013625559166352 3.8263932103356013 0.3376838752678493 0.9994900883603742 0.00586948892154295 12.749859082618086 0.14529437588582858 14.879226506885425 0.06478850644778304 1.0000000000000123e-14 13.999999999999995 -3.488709335067752 ATAGAYIASQTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATAGAYIASQTVK 13 0 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 0 19207700.0 4247500.0 10241000.0 4719200.0 False True 5498472.480742227 9671079.347437494 3860354.0230810978 1.0 1.7588665545402558 0.7020775381892966 22.390599451499916 -6.714000194032693 1.780889451989009 1.4646339664336432 0.7042619959965758 0.4839796532535352 0.3195933018990054 0.3671578401326815 2.2722892246965722 0.1426774900567948 0.3607281953833851 1.9319674538585186e-07 6.714000194032693 -0.7603719704370674 ATAGAYIASQTVK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATAGAYIASQTVKK 14 1 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 1 29591400.0 16297000.0 4927600.0 8366800.0 True False 15779660.655526793 6895216.377094529 6175284.081380265 1.0 0.4369686096309995 0.39134454258478524 23.91156284447718 -13.999999999999998 0.3561333721764858 8.191826463425048 0.38554359628788054 0.9997662185420462 0.004232192616132169 21.285833909004086 0.19256108377731385 116.14345728511371 0.013334199673424299 1.0000000000000041e-14 13.999999999999998 -7.806282867137168 ATAGAYIASQTVK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATAGAYIASQTVKK 14 1 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 1 18658500.0 7412200.0 6369400.0 4876900.0 True False 9595239.01630548 6014937.290847409 3989354.2412197418 1.0 0.6268668535120432 0.4157639256761099 23.19388731356075 -9.839196647585362 0.12728175770219272 1.7111711616385812 1.1461167027444917e-07 0.9998550269428695 0.0029083904679290886 1.3625976676692044 0.056221402520539206 0.5473193991715707 0.22218952262328648 1.448116001334185e-10 9.839196647585362 -1.7111710470269108 ATAGAYIASQTVKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATAGAYIASQTVKK 14 1 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 1 38310000.0 13235000.0 13241000.0 11834000.0 True False 17351213.1679223 11265494.413013741 10609531.199743645 1.0 0.6492626367959443 0.6114576022475362 24.04853320137572 -13.999999999999998 0.31461171036200875 4.483397307270163 0.6034925197932592 0.9996820831679786 0.0031190726681422287 17.604343862995712 0.1786438333179938 40.24599486782258 0.012857849978340285 1.0000000000000041e-14 13.999999999999998 -3.879904787476904 ATAGAYIASQTVKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATAGAYIASQTVKK 14 1 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 1 94895900.0 28353000.0 32152900.0 34390000.0 True False 43013573.88195149 26414963.78324569 27592801.426327527 1.0 0.6141076269491157 0.6414905560289998 25.358288670117727 -10.752391362824952 6.915592020802112 1.0072180034645934 0.6277990914892554 0.9959569705923158 0.01117903398475591 0.0012516874056668894 4.481585556836819e-05 0.01089013282508115 0.003608017704137193 1.768514549849681e-11 10.752391362824952 -0.37941891197533806 ATAGAYIASQTVKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATAGAYIASQTVKK 14 1 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 1 30895200.0 13235000.0 7977200.0 9683000.0 True False 18128337.162426587 7624740.926927251 7396074.827644831 1.0 0.42059792128814494 0.40798418307081075 24.11174326289861 ATAGAYIASQTVKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATAGAYIASQTVKK 14 1 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 1 64550000.0 28353000.0 21110000.0 15087000.0 True False 36703517.42118525 19935209.94281862 12341320.805692613 1.0 0.5431416753346923 0.33624354483718255 25.129414992210176 -12.461227973356689 0.12443580793028991 2.519199853268319 1.8470756981076052e-14 0.9997215966170057 0.004627002896193803 6.73877572296678 0.09312515427683311 2.861415271100724 0.2665018513122029 3.457578321955295e-13 12.461227973356689 -2.5191998532683004 ATAGDTHLGGEDFDNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATAGDTHLGGEDFDNR 16 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931;P17066;P48741 P0DMV9;Q53FA3;P17066 HSPA1B;HSPA1A;HSPA1L;HSPA6;HSPA7 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 39417700.0 8533600.0 2725100.0 28159000.0 False True 8262705.53905647 3813246.641208768 20783313.148107637 1.0 0.46150097243380744 2.5153157219349382 22.97818282417316 -6.837022334723076 1.2960830796512377 0.7133283866237453 2.5790128299497384 0.919229835878339 0.2471135318254957 0.17229959723777344 0.5635000433748728 0.14957135195104532 0.34437037019324684 1.4553842317386197e-07 6.837022334723076 1.8656844433259931 up ATAMGK(ub)NYVNGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ATAMGKNYVNGK 12 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 27905840.0 5699540.0 8379200.0 13827100.0 True False 7472152.1344238715 7129056.021865777 12396404.330908861 1.0 0.9540833609399538 1.6590139103029204 22.833092398213356 -6.891342565855902 1.0143876693906708 0.963333367284516 1.7212680502337994 0.9817444264345236 0.04351061290221488 0.11806138793578451 0.21552979242153295 0.03262318485528892 0.08173476541492507 1.284273242230266e-07 6.891342565855902 0.7579346829492833 ATAMGK(ub)NYVNGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ATAMGKNYVNGK 12 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 61778420.0 7066620.0 11297700.0 43414100.0 True False 6842294.016172217 15808930.526727177 32042644.81491744 1.0 2.3104722611103408 4.683026590085507 22.706048667957898 -6.961944302371229 0.4071057053044266 0.879372092485423 6.201761128187583 0.9998356517186608 0.019541103694355216 0.0790137477194137 0.018617834531147653 0.03053169690495491 0.1982801667238828 1.0915803210434032e-07 6.961944302371229 5.32238903570216 ATAMGK(ub)NYVNGK ddPTM_RPMI8226_Bortezomib_8h_R1 2 ATAMGKNYVNGK 12 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 160424300.0 14693900.0 34599400.0 111131000.0 True False 22291720.56798249 28424866.74365395 89165909.13955227 1.0 1.2751311257902842 3.999956345568987 24.41000463832818 -6.926354431285581 0.7761351382997524 0.9524871895835273 4.510727231817521 0.9957719267217768 0.0880427068803239 0.09457537661334095 0.08728174257978344 0.07853540693088372 0.25167237605640147 1.1848014273477096e-07 6.926354431285581 3.5582400422339937 up ATAMGK(ub)NYVNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ATAMGKNYVNGK 12 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 30700140.0 5699540.0 7075000.0 17925600.0 True False 7806813.962277062 6762403.106103676 13691942.469320495 1.0 0.8662180421846819 1.7538451070411931 22.896302459736248 -6.868512069154699 1.142009740252902 0.9249851701962142 1.8043639666644886 0.9631717032145035 0.07498470794980315 0.1382856802015544 0.33801284319534597 0.051004363732040744 0.12044647081305421 1.3535924734678178e-07 6.868512069154699 0.8793787964682744 ATAMGK(ub)NYVNGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ATAMGKNYVNGK 12 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 43960320.0 7066620.0 16262100.0 20631600.0 True False 5876207.634346262 16174492.839525884 24945572.170259744 1.0 2.7525393665442395 4.245182219983787 22.486453943392174 -7.267785514796948 0.20009537269899028 3.339662564169577e-14 6.599433350916688 0.9999824369275209 0.005558111230157597 0.10552162316084439 0.011747743240642924 0.10086276215492918 0.2538824716693441 5.397771366652263e-08 7.267785514796948 6.599433350916654 ATAMGK(ub)NYVNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ATAMGKNYVNGK 12 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 90355500.0 14693900.0 23954600.0 51707000.0 True False 19021543.210071396 22621505.45221428 42296856.55862319 1.0 1.1892571071855411 2.2236290763321525 24.181130960420628 -6.937841657461036 0.6793537489241249 0.9878419790112519 2.4856971471124525 0.9978672161125924 0.02483649017437923 0.08876535091099012 0.05919966518903012 0.023797924146311912 0.08990578467168722 1.1538738802886166e-07 6.937841657461036 1.4978551681012005 up ATAMGK(ub)NYVNGK(ub)TFLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATAMGKNYVNGKTFLEK 17 2 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 2 13255040.0 836240.0 1865300.0 10553500.0 True False 809694.0189346333 2610124.017411 7789221.751786422 1.0 3.2235930566034177 9.619957131504075 19.627017295071028 -6.952391120637154 0.5319465152709928 0.9005085890328988 12.234379840070675 0.9993758131292131 0.09128905899488936 0.08253957629184343 0.03209697475056981 0.10155663108070657 0.5290812825363207 1.1158578663146457e-07 6.952391120637154 11.333871251037776 ATAPVPTVGEGYGYGHESELSQASAAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATAPVPTVGEGYGYGHESELSQASAAAR 28 0 Q9BWF3;E9PB51 Q9BWF3 RBM4 RNA-binding protein 4 0 7237160.0 2624200.0 714160.0 3898800.0 False True 2540896.2074144543 999327.812295201 2877587.318507122 1.0 0.39329737648437413 1.1325088014654778 21.276906013543943 -6.688576044546061 1.8715311069063998 0.6191471171526489 1.129914215809831 0.36391106401412776 0.2566636134196584 0.4196416526145048 2.848670127247374 0.109759000815791 0.2863282874265401 2.048443338095136e-07 6.688576044546061 0.5107670986571821 ATAPVSFNYYGVVTGPSASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATAPVSFNYYGVVTGPSASK 20 0 F5GXQ0;Q5VW32;Q5VW33;Q5VW32-2 F5GXQ0 BROX BRO1 domain-containing protein BROX 0 6638900.0 1680000.0 2578200.0 2380700.0 False True 2202496.2691431437 2193542.609744887 2134368.001286947 1.0 0.995934767507352 0.9690677034006051 21.070708144659083 -6.9338250748851555 0.7146983427966184 1.0003562896423113 0.9629732993082382 0.9972379973995675 0.0007212466763664263 0.09069903653740782 0.06830275419632575 0.0006727477603121002 0.0023819306057047416 1.1645950104899342e-07 6.9338250748851555 -0.03738299033407311 ATAPVSFNYYGVVTGPSASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATAPVSFNYYGVVTGPSASK 20 0 F5GXQ0;Q5VW32;Q5VW33;Q5VW32-2 F5GXQ0 BROX BRO1 domain-containing protein BROX 0 5898100.0 1680000.0 1556300.0 2661800.0 False True 2301141.400292914 1487537.5200041225 2033137.6614917908 1.0 0.646434643179586 0.883534432622433 21.133918206181974 -10.032045237488033 5.937118814173257 1.0000004209533695 0.7649845379009862 0.5670984225723561 0.09679558370946689 5.393727938480861e-07 8.78572729042758e-08 0.09372208920646068 0.031240640307753826 9.288696277398149e-11 10.032045237488033 -0.2350158830523833 ATATISAKPQITNPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATATISAKPQITNPK 15 1 Q9Y2W2 Q9Y2W2 WBP11 WW domain-binding protein 11 0 6583900.0 1875800.0 1909000.0 2799100.0 False True 2459191.965273042 1624184.641223718 2509475.9828631417 1.0 0.6604545981604107 1.02044737389361 21.22975292586771 -11.030500498206425 12.619719252565664 1.3870809952182592 0.8404509860270103 0.2075456622745535 0.1469664352724194 0.04418632760630276 0.00010679369298529377 0.003928448919985821 0.04743321302179588 9.321794009795671e-12 11.030500498206425 -0.5466300091912489 ATATISAKPQITNPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATATISAKPQITNPK 15 1 Q9Y2W2 Q9Y2W2 WBP11 WW domain-binding protein 11 0 5559500.0 1875800.0 1841400.0 1842300.0 False True 2569333.951588958 1760040.8593044986 1407186.6833595054 1.0 0.6850183325589237 0.5476853962441341 21.292962987390602 -13.999999999999998 0.11291782965518862 2.5127812598909416 0.3060147886627381 0.9997282754631946 0.003121163610629739 11.996221715736349 0.10243374495913483 4.115994226035337 0.21452462731357622 1.0000000000000041e-14 13.999999999999998 -2.2067664712282036 ATAVMPDGQFK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ATAVMPDGQFK 11 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 94994170.0 2716070.0 52472800.0 39805300.0 False True 3560794.072459293 44644062.777372405 35686629.39539936 1.0 12.537670493968948 10.022098630026106 21.763767573620417 -9.329167335384192 10.7379475272264 1.0000000216957272 11.279884561789833 0.957018783151965 1.0269779129936814 0.0 0.0 0.9943671033040583 0.33145569616227794 4.686327812874225e-10 9.329167335384192 10.279884540094105 ATAVMPDGQFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATAVMPDGQFK 11 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 74988000.0 23322000.0 7967000.0 43699000.0 False True 22581655.875817373 11148264.647356145 32252920.958100595 1.0 0.49368676542869416 1.428279712323495 24.428647944664345 -6.759575750103899 1.6140215524336172 0.7057478160912264 1.4316270882026563 0.6892361322209171 0.2129443645962676 0.2836386844200465 1.4561929587831766 0.10410055920756453 0.25027949821718715 1.7394992662706669e-07 6.759575750103899 0.7258792721114299 ATAVMPDGQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ATAVMPDGQFK 11 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 122993270.0 2716070.0 61503800.0 58773400.0 False True 3720274.4780318853 58786358.75013141 44892333.39616871 1.0 15.801618697024422 12.066941205885925 21.826977635143308 -9.588157141665222 9.439343493920523 1.0000000012091774 13.934279943366498 0.9411505945720351 1.5246757011911651 0.0 0.0 1.476260899770122 0.4920869665900406 2.581326015138644e-10 9.588157141665222 12.934279942157321 ATAVMPDGQFK(ub)DISLSDYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATAVMPDGQFKDISLSDYK 19 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 9679600.0 2090500.0 3338600.0 4250500.0 True False 2740665.7444308 2840493.893760876 3810699.0336750387 1.0 1.036424780925194 1.3904282349712334 21.3860949550371 -6.926663876305195 0.7736709161628985 0.9938992589442769 1.4572951471450113 0.9958413713865899 0.011355798075508588 0.09440682954723013 0.08643558116175071 0.010147411186064319 0.032638288815571806 1.183957529184946e-07 6.926663876305195 0.4633958882007344 ATAVMPDGQFK(ub)DISLSDYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATAVMPDGQFKDISLSDYK 19 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 16274500.0 3304900.0 4809300.0 8160300.0 True False 3199987.7585107964 6729678.570168187 6022872.626247481 1.0 2.103032598255948 1.8821548958207244 21.609634955446328 -10.19870788602823 4.7718305646577885 0.9998510154226655 1.992593747042134 0.9641915701856477 0.0901729444338246 0.00014294486838984836 2.4003412461535172e-05 0.08732244330667728 0.02910319267070347 6.328373656016102e-11 10.19870788602823 0.9927427316194685 ATAVMPDGQFK(ub)DISLSDYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATAVMPDGQFKDISLSDYK 19 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 55073100.0 8214100.0 19386000.0 27473000.0 True False 12461390.23114795 15926416.83649066 22042949.508156344 1.0 1.2780609980964788 1.768899705352196 23.57096169306292 -6.962411346686508 0.4000008039205945 0.9730182134094478 2.091864923424865 0.9998494426750764 0.0039004793795540216 0.0788507238500693 0.01802916243639573 0.0063156256464851285 0.04112423176963699 1.0904070564212343e-07 6.962411346686508 1.1188467100154174 ATAVMPDGQFK(ub)DISLSDYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATAVMPDGQFKDISLSDYK 19 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 9484900.0 2090500.0 2288900.0 5105500.0 True False 2863414.3436382967 2187768.82961989 3899686.0510730925 1.0 0.7640420026813439 1.3619007181887948 21.44930501655999 -6.79963538186107 1.457359039324152 0.8697474978768992 1.3700825857284287 0.8310873758340628 0.10105144243824156 0.22129027497083778 0.927922154536625 0.05454865136706634 0.12689069121303065 1.5862243709178404e-07 6.79963538186107 0.5003350878515295 ATAVMPDGQFK(ub)DISLSDYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATAVMPDGQFKDISLSDYK 19 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 11216000.0 3304900.0 3765500.0 4145600.0 True False 2748170.7818944505 3745214.504106773 5012425.792911299 1.0 1.3628026790696794 1.823913501276651 21.390040230880604 -6.967864130340356 0.304918770246518 0.9245617675524131 2.2767048280420132 0.9999606020850393 0.002116260188288584 0.077002026126463 0.011497806644158249 0.007469488673433044 0.04114460615116668 1.0768020400214667e-07 6.967864130340356 1.3521430604896 ATAVMPDGQFK(ub)DISLSDYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATAVMPDGQFKDISLSDYK 19 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 60741100.0 8214100.0 16978000.0 35549000.0 True False 10633314.374117654 16033159.375138532 29079446.76354253 1.0 1.5078233193372461 2.7347490857906216 23.34208801515537 -6.95618949129534 0.48617137980425473 0.9721942538521211 3.3220688071839755 0.9996017285546221 0.014532661778219028 0.08109147012964094 0.026382522825675953 0.017521619298895227 0.10119580064986333 1.1061410473956938e-07 6.95618949129534 2.3498745533318544 ATAVVDGAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATAVVDGAFK 10 0 P32119;A6NIW5;P32119-2 P32119 PRDX2 Peroxiredoxin-2 0 64540000.0 13751000.0 26394000.0 24395000.0 False True 18027694.164873447 22456118.083006192 21870839.41336373 1.0 1.2456456093404018 1.2131800780145563 24.103711544640202 -10.083122758142462 4.472569812107762 0.9999819114159245 1.2294128436905727 0.9852022288104446 0.013253997708056119 9210511.106513469 0.16014447565102968 1725.3511067855957 0.004537195944402479 8.258044938034021e-11 10.083122758142462 0.22943093227464817 ATAVVDGAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATAVVDGAFK 10 0 P32119;A6NIW5;P32119-2 P32119 PRDX2 Peroxiredoxin-2 0 29308500.0 9316900.0 3087600.0 16904000.0 False True 9021140.10931322 4320494.781621293 12476335.290870117 1.0 0.4789300165242875 1.383010920979914 23.10487834494557 -6.750431212626228 1.6483344187861166 0.6937599961188515 1.3848564133257535 0.6507710577297854 0.21896170454713704 0.29930338901521625 1.6001358848174438 0.10493238604522725 0.25462367742609626 1.7765146259927096e-07 6.750431212626228 0.691096417206902 ATAVVDGAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATAVVDGAFK 10 0 P32119;A6NIW5;P32119-2 P32119 PRDX2 Peroxiredoxin-2 0 48191000.0 13751000.0 13049000.0 21391000.0 False True 18835116.30680231 12472452.032727493 16338886.361473778 1.0 0.6621913998069161 0.8674693638909456 24.166921606163093 -10.314634516482924 5.7021954663099335 1.000029059842832 0.7648303818489292 0.6363521539584738 0.0838043779072134 3.0964015379853204e-05 3.7216925763581493e-06 0.0811532551184139 0.02704774666449164 4.845799976778366e-11 10.314634516482924 -0.23519867799390293 ATAVVDGAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATAVVDGAFK 10 0 P32119;A6NIW5;P32119-2 P32119 PRDX2 Peroxiredoxin-2 0 18949000.0 9316900.0 6511200.0 3120900.0 False True 7747415.158653039 6476122.873227986 3773465.760588785 1.0 0.8359075563408842 0.4870612563435723 22.885283620379845 -6.958833381430832 0.4515761020635134 1.0110701011720447 0.29803296098368304 0.9997244496571784 0.0035504460245502907 0.08012053716321753 0.022691325636674062 0.004673764600822412 0.02884872420375675 1.0994275576880017e-07 6.958833381430832 -0.7130371401883616 down ATCIGNNSAAAVSMLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATCIGNNSAAAVSMLK 16 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 19964200.0 3724900.0 8553600.0 7685700.0 False True 4883379.971982915 7277436.221671654 6890457.490440244 1.0 1.4902457444278339 1.4110017098756187 22.21944860664176 -10.673598274439279 6.526553455821858 0.9966616202174261 1.450623727151725 0.9773322428830474 0.03235124163540114 0.0015791553247524635 7.897557750176437e-05 0.031476685848621545 0.010441318340253388 2.120321541291513e-11 10.673598274439279 0.45396210693429895 ATCIGNNSAAAVSMLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATCIGNNSAAAVSMLK 16 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 16286900.0 3724900.0 6200400.0 6361600.0 False True 5102096.191637546 5926445.826019118 4859121.101264628 1.0 1.1615707747205355 0.9523773991617093 22.28265866816465 -6.700480919938539 1.8292917761035905 1.1002838207730006 0.952997378082939 0.419761290365648 0.06819535557114165 0.3945426169105646 2.567145089926855 0.02973804453438444 0.07642913316885144 1.9930540660125373e-07 6.700480919938539 -0.14728644269006153 ATCIGNNSAAAVSMLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATCIGNNSAAAVSMLK 16 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 5370300.0 4264400.0 1105900.0 0.0 False True 3546037.544951649 1099942.2971960364 0.0 1.0 0.31018912892278316 0.0 21.757776380695802 -8.698059960511502 0.4948193655968659 1.0715498355519437 6.434009259831984e-20 0.9947022713274354 0.03041989044973942 0.3193120679435221 0.19040045904237635 0.10810025576161883 0.062208442254306606 2.004195300681925e-09 8.698059960511502 -1.0715498355519437 ATCIGNNSAAAVSMLK(ub)QDYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATCIGNNSAAAVSMLKQDYK 20 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 1 30290400.0 14047000.0 9728800.0 6514600.0 True False 13601085.67393906 13613560.57502177 4808230.826189209 1.0 1.000917198919393 0.35351816328914276 23.697218479944013 -6.90657585502686 0.9187225583893426 1.022279792114389 0.2756985681976444 0.9895642288306293 0.031154489111534504 0.10672682781510971 0.15136656925304626 0.025082352202335755 0.06770237349011929 1.2400070232855516e-07 6.90657585502686 -0.7465812239167445 down ATCIGNNSAAAVSMLK(ub)QDYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATCIGNNSAAAVSMLKQDYK 20 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 1 175982000.0 35375000.0 65953000.0 74654000.0 True False 53666461.258915655 54183171.85685907 59898604.17798946 1.0 1.0096281846393882 1.116127331165113 25.677517424829855 -6.92460291099027 0.7898339466881519 0.9980165738839278 1.1352616990964177 0.995367024585942 0.003581665729618933 0.0955385438420482 0.09212917681254633 0.0031637617178926583 0.009937576188928767 1.1895894090920451e-07 6.92460291099027 0.13724512521248988 ATCIGNNSAAAVSMLK(ub)QDYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATCIGNNSAAAVSMLKQDYK 20 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 1 30571300.0 14047000.0 6432300.0 10092000.0 True False 11680702.887612753 6397647.923188408 12202190.53986416 1.0 0.5477108684934566 1.0446452287391403 23.47762375537829 -6.667113044841784 1.9472603563768076 0.7106030183035275 1.0426301369271762 0.2665137709880102 0.19224919445420888 0.46775177445608623 3.416455879197822 0.079554302759839 0.21337942551061045 2.15222144853463e-07 6.667113044841784 0.33202711862364875 ATCIGNNSAAAVSMLK(ub)QDYK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ATCIGNNSAAAVSMLKQDYK 20 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 1 206041400.0 40894500.0 75815900.0 89331000.0 True False 52938736.401109554 71596678.51746769 73073674.61346358 1.0 1.3524440397479356 1.3803441408157981 25.657820423653664 -12.052555132935312 0.3968203963513017 8.20995692408621e-06 1.3823100156695942 0.9997362470785823 0.0028111383726560557 5.83348314864606 0.20279745204337227 4.858147422994633 0.007198926888055025 8.860227374615697e-13 12.052555132935312 1.3823018057126701 ATCK(ub)DLVMFI ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATCKDLVMFI 10 1 P54819;A0A5K1VW67;P54819-6 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed 1 7248100.0 1950000.0 3198400.0 2099700.0 True False 2556468.8838268635 2721211.1872655535 1882443.1857446113 1.0 1.0644413489563314 0.736345041261257 21.285721035629933 -6.8557086002554595 1.2071330181098239 1.0346401624173684 0.7217041469064011 0.9482153781036534 0.03229940987862167 0.15129199054792733 0.42136542541418065 0.020901697728587038 0.04858162106557544 1.3940918868106737e-07 6.8557086002554595 -0.3129360155109674 ATCK(ub)DLVMFI ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATCKDLVMFI 10 1 P54819;A0A5K1VW67;P54819-6 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed 1 9387400.0 4912900.0 2505700.0 1968800.0 True False 4756942.678685494 3506239.0770528815 1453112.2172660378 1.0 0.7370782693605582 0.30547187877142606 22.181603210206962 -6.9690972540603 0.3805662787686197 1.0295638462486836 1.0928180857458568e-18 0.9998846943439049 0.003074447522627943 0.07761494474254536 0.016405761147970585 0.005594920577154268 0.036105022466739266 1.0737489346440413e-07 6.9690972540603 -1.0295638462486836 down ATCK(ub)DLVMFI ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATCKDLVMFI 10 1 P54819;A0A5K1VW67;P54819-6 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed 1 7038900.0 1950000.0 2176500.0 2912400.0 True False 2670967.696768561 2080335.033276984 2224551.1027608006 1.0 0.7788694096876773 0.8328633496586828 21.348931097152825 -10.125243246377389 5.029133364357431 1.0000077416255668 0.8058663796727119 0.9451650467776257 0.02204293369019666 1.9134219223470115e-06 3.3281948089091127e-07 0.02134382984386428 0.007114326256741106 7.494743145750108e-11 10.125243246377389 -0.19414136195285492 ATCK(ub)DLVMFI ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATCKDLVMFI 10 1 P54819;A0A5K1VW67;P54819-6 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed 1 9492000.0 4912900.0 2878600.0 1700500.0 True False 4085294.028372793 2863092.410442635 2056066.687776356 1.0 0.7008289710748259 0.5032848733767407 21.96200848564124 -8.378748179865358 0.12066255224328942 1.4825254790677436 4.4960585069335104e-10 0.9999628883701198 0.001243916148218679 0.10684592709847282 0.027166839744332098 0.1593081014599769 0.1512046441278493 4.1807271052654085e-09 8.378748179865358 -1.4825254786181377 ATCLEEMTK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATCLEEMTKR 10 1 Q9BXR0 Q9BXR0 QTRT1 Queuine tRNA-ribosyltransferase 1 8291300.0 1255400.0 1011300.0 6024600.0 True False 1645841.5573108923 860417.982016524 5401232.18404391 1.0 0.52278299705978 3.2817449286363116 20.650394025688676 -6.862298076611456 1.1739673910381683 0.7393000005708094 3.421397274617294 0.9563790963916224 0.2514572783507276 0.14445899488598823 0.377002648820537 0.16688971806833444 0.3906612827930112 1.3730992293142015e-07 6.862298076611456 2.682097274046485 up ATCLEEMTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATCLEEMTKR 10 1 Q9BXR0 Q9BXR0 QTRT1 Queuine tRNA-ribosyltransferase 1 6034730.0 800830.0 1050200.0 4183700.0 True False 775408.0900021793 1469550.3367206492 3087863.4616903295 1.0 1.8951960337640004 3.98224302983691 19.564596261557295 -6.956940719952458 0.4766051567955247 0.9482690204413703 5.015685654999771 0.9996393373585262 0.023729118707875498 0.0808127437894022 0.02531169330987627 0.029227141997040195 0.17218760437640682 1.104229333997861e-07 6.956940719952458 4.067416634558401 ATCLEEMTK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATCLEEMTKR 10 1 Q9BXR0 Q9BXR0 QTRT1 Queuine tRNA-ribosyltransferase 1 73984000.0 3353000.0 10785000.0 59846000.0 True False 5086746.137134809 8860332.486410392 48017411.86856644 1.0 1.741846800988798 9.43971068617413 22.278311665129667 -6.925600233375779 0.7820690848324162 0.8619048292787763 10.856411301650517 0.9956005026227086 0.25309050834193153 0.09498751733622916 0.08935162768017467 0.2248047677944551 0.7141132069988345 1.1868607468642484e-07 6.925600233375779 9.994506472371741 up ATCLEEMTK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATCLEEMTKR 10 1 Q9BXR0 Q9BXR0 QTRT1 Queuine tRNA-ribosyltransferase 1 9515800.0 1255400.0 1369400.0 6891000.0 True False 1719555.3059093573 1308895.37999977 5263487.724599871 1.0 0.7611824845072857 3.0609586714143897 20.713604087211568 -6.881265467260829 1.0726779992987483 0.8493422990545082 3.227975158405905 0.9746935526244079 0.16424196021898557 0.12651675343104266 0.26554171029402085 0.11780646320737487 0.2858337807717044 1.3144211322622522e-07 6.881265467260829 2.378632859351397 up ATCLEEMTK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATCLEEMTKR 10 1 Q9BXR0 Q9BXR0 QTRT1 Queuine tRNA-ribosyltransferase 1 11723230.0 800830.0 1743800.0 9178600.0 True False 665925.6277843609 1734405.8032827987 11097802.822948588 1.0 2.6045037627601735 16.66522860799444 19.34500153699157 -6.928440864476672 0.759477988564334 0.7733542865821922 19.44048843273411 0.9962229029190117 0.43248228324213045 0.09345549304545153 0.08170494734192109 0.39041841541109695 1.2833333941436318 1.1791230671040384e-07 6.928440864476672 18.667134146151916 ATCLEEMTK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATCLEEMTKR 10 1 Q9BXR0 Q9BXR0 QTRT1 Queuine tRNA-ribosyltransferase 1 47531200.0 3353000.0 6309200.0 37869000.0 True False 4340524.597511165 5958087.473767467 30977230.568752766 1.0 1.3726652942328226 7.136748075685357 22.049437987222117 -6.920054986608954 0.824317768246512 0.8730707825209924 8.067438228589458 0.9941961842486896 0.2140108006943572 0.0981395316661467 0.10544642564289743 0.18444565311016747 0.5527940820217325 1.2021122239349908e-07 6.920054986608954 7.1943674460684655 up ATDLRPIYISVQPPSLHVLEQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATDLRPIYISVQPPSLHVLEQR 22 1 B1ANH0;B1ANG9;B1ANH2;Q16774;Q16774-2;Q16774-3;B1ANH5;B1ANH3 B1ANH0 GUK1 Guanylate kinase 0 31260500.0 9837500.0 11410000.0 10013000.0 False True 9525213.947275259 15966072.502363954 7390294.916438853 1.0 1.6761904342244343 0.775866553480711 23.183320066886203 -6.705746578390737 1.81054931414463 1.4175024677866346 0.7782508849572047 0.44483100200255665 0.2851396982263433 0.3836727741321546 2.448984976300698 0.12546119539907866 0.320363363533327 1.9690349352983127e-07 6.705746578390737 -0.6392515828294298 ATDLRPIYISVQPPSLHVLEQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATDLRPIYISVQPPSLHVLEQR 22 1 B1ANH0;B1ANG9;B1ANH2;Q16774;Q16774-2;Q16774-3;B1ANH5;B1ANH3 B1ANH0 GUK1 Guanylate kinase 0 100281000.0 31684000.0 39764000.0 28833000.0 False True 48066944.41067085 32667803.522449926 23134144.912047174 1.0 0.6796313750120069 0.4812901089446285 25.51854175926868 -9.089871280206905 0.11724726037451184 1.596794114594934 3.021134978706516e-10 0.9999320497575644 0.0017616168681639536 0.5501440475626296 0.03913265295376197 0.3087267140536407 0.20052197725647478 8.130714653055641e-10 9.089871280206905 -1.5967941142928206 ATDLRPIYISVQPPSLHVLEQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATDLRPIYISVQPPSLHVLEQR 22 1 B1ANH0;B1ANG9;B1ANH2;Q16774;Q16774-2;Q16774-3;B1ANH5;B1ANH3 B1ANH0 GUK1 Guanylate kinase 0 29552200.0 9837500.0 11788000.0 7926700.0 False True 8180317.125143482 11724495.704265203 9584136.321080172 1.0 1.4332568682732525 1.1716093856094933 22.96372534232048 -10.365322408595302 5.016731835317042 0.9998020196526837 1.3024331269414213 0.6404703585768845 0.10681713750182106 0.0002366832698205393 2.994309137130028e-05 0.10349240530538233 0.03447508288615097 4.3119884749842753e-11 10.365322408595302 0.30263110728873766 ATDLRPIYISVQPPSLHVLEQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATDLRPIYISVQPPSLHVLEQR 22 1 B1ANH0;B1ANG9;B1ANH2;Q16774;Q16774-2;Q16774-3;B1ANH5;B1ANH3 B1ANH0 GUK1 Guanylate kinase 0 79439000.0 31684000.0 27586000.0 20169000.0 False True 41015562.585011564 26050814.849957127 16498448.95141604 1.0 0.635144642864827 0.4022485103604337 25.28966808136113 -8.561483326504174 0.1550749995203375 1.4182511371293058 9.963147371905008e-11 0.9998801988100494 0.002692612131365314 0.18227556494315109 0.03985365099347935 0.1780463863985451 0.14726582997362647 2.7448377216578254e-09 8.561483326504174 -1.4182511370296744 down ATDPQQVAFPSPAELPDQK(ub)QLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATDPQQVAFPSPAELPDQKQLR 22 1 E9PSE3;M9RSF4;Q92985-2;Q92985;Q92985-4 E9PSE3 IRF7 Interferon regulatory factor 7 1 129869600.0 4673600.0 11616000.0 113580000.0 True False 7090192.885927006 9543034.043777768 91130863.2161175 1.0 1.3459484385423832 12.853086606007421 22.7573934452777 -6.913319501556271 0.8728314267866247 0.6800241120596306 14.45078492535906 0.9921149911269391 0.4890853812480117 0.10226342584724199 0.12716559154672322 0.40711278078386376 1.151412291265605 1.220901137729345e-07 6.913319501556271 13.770760813299429 up ATDPQQVAFPSPAELPDQK(ub)QLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATDPQQVAFPSPAELPDQKQLR 22 1 E9PSE3;M9RSF4;Q92985-2;Q92985;Q92985-4 E9PSE3 IRF7 Interferon regulatory factor 7 1 82675300.0 4673600.0 6460700.0 71541000.0 True False 6050067.3304289235 6101156.365588268 58521272.07264896 1.0 1.0084443746439633 9.67282988377917 22.52851976737015 -6.907108657829484 0.9151965889006108 0.7065911670393189 10.72598646888245 0.9897840291632796 0.4130313995920185 0.10636122745565951 0.14936717346792688 0.333392753424867 0.9028850841813487 1.2384866859522847e-07 6.907108657829484 10.019395301843131 up ATEGMVVADKNCSK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATEGMVVADKNCSK 14 1 Q99436;Q5TBG5;Q99436-2 Q99436 PSMB7 Proteasome subunit beta type-7;Proteasome subunit beta type 1 2049700.0 1042800.0 1006900.0 0.0 True False 1009696.8847998615 1408960.4209141338 0.0 1.0 1.3954291056304615 0.0 19.945490824252186 -6.858810623167124 1.3862093541690874 1.2089863477885123 1.2027308904575678e-22 0.9069567043477691 0.17912376919315143 0.16651063866295257 0.6432219622442812 0.10415690250997407 0.21765477818311094 1.3841698233278143e-07 6.858810623167124 -1.2089863477885123 down ATEGMVVADKNCSK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATEGMVVADKNCSK 14 1 Q99436;Q5TBG5;Q99436-2 Q99436 PSMB7 Proteasome subunit beta type-7;Proteasome subunit beta type 1 19221390.0 657190.0 2783100.0 15781100.0 True False 850745.4101516138 2628218.0384584796 12909101.727760034 1.0 3.089312039885231 15.17387172909868 19.69836793717794 -6.936615810459901 0.6903286165024558 0.853195208147914 18.131965183963032 0.9976861999466544 0.3005252797295948 0.08934497816320262 0.06189784597332172 0.2855192448426162 1.056529312184747 1.1571354252355865e-07 6.936615810459901 17.27876997581512 ATEK(ub)VACCPLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATEKVACCPLER 12 1 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 42463700.0 2388100.0 5126000.0 34949600.0 True False 3622922.293495872 4211225.2503792 28041796.241046123 1.0 1.1623835426830686 7.740104249927953 21.788722431700965 -6.912208392070619 0.8805683566579504 0.8102892142215373 8.631555365534883 0.9917284628046164 0.28555317295847094 0.10297553003976345 0.1309824579413624 0.23636960868920504 0.6629097190261893 1.2240287198054098e-07 6.912208392070619 7.8212661513133455 up ATEK(ub)VACCPLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATEKVACCPLER 12 1 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 35158200.0 2388100.0 6120600.0 26649500.0 True False 3091442.526488646 5779983.229560186 21799564.44696127 1.0 1.8696719023676194 7.051583285205653 21.559848753793414 -6.935981864916398 0.6959384638407634 0.9358688063386084 8.297939372342995 0.99758884240662 0.13117804788919898 0.08964844886491638 0.06332082895647344 0.12409432635791383 0.45444870560219247 1.1588257448956455e-07 6.935981864916398 7.362070566004387 ATENDIANFFSPLNPIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATENDIANFFSPLNPIR 17 0 P31942-2;P31942;P31942-3;P31942-4;P31942-6;P31942-5 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 7150300.0 1425100.0 4376700.0 1348500.0 False True 1868319.9006880296 3723713.4202429773 1208970.1557253923 1.0 1.993081280604932 0.6470894814534575 20.833310069137504 -6.709035874362711 1.798518635786102 1.6111336984604412 0.6503364296888889 0.46051488475545643 0.4185448835605633 0.37705147834520025 2.3768453378004146 0.18522991179454287 0.47114366445027933 1.9541780266304366e-07 6.709035874362711 -0.9607972687715522 ATENDIANFFSPLNPIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATENDIANFFSPLNPIR 17 0 P31942-2;P31942;P31942-3;P31942-4;P31942-6;P31942-5 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 24193300.0 8424800.0 4841500.0 10927000.0 False True 8157359.3355023675 6774736.198088955 8064890.897026601 1.0 0.8305060399391779 0.9886644152019483 22.95967077420057 -10.483158959383896 7.206233586771092 1.000017051481876 0.9095852275753351 0.3034978368315937 0.06456788632356811 1.769175803642892e-05 1.2687937232381073e-06 0.06252937249412761 0.020839195702582733 3.287312874468744e-11 10.483158959383896 -0.09043182390654092 ATENDIANFFSPLNPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATENDIANFFSPLNPIR 17 0 P31942-2;P31942;P31942-3;P31942-4;P31942-6;P31942-5 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 10233100.0 1425100.0 2932600.0 5875400.0 False True 1951997.9818794208 2803028.0351886465 4487751.527661308 1.0 1.4359789616635965 2.299055413643622 20.896520130660395 -6.960244550051658 0.43197298994383143 0.9664261279890198 2.8018138786628897 0.9997791631253518 0.008021842488558565 0.07961387259389296 0.020809340579085938 0.011276256972802821 0.07162985012543915 1.0958609460299047e-07 6.960244550051658 1.8353877506738698 up ATENDIANFFSPLNPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATENDIANFFSPLNPIR 17 0 P31942-2;P31942;P31942-3;P31942-4;P31942-6;P31942-5 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 10044000.0 8424800.0 0.0 1619200.0 False True 7005594.481922111 0.0 1957767.2336650856 1.0 0.0 0.27945768752631783 22.740076049634848 -10.357818009135043 5.235841101522598 1.0003734844282304 0.13972884376319997 0.9266596597946527 0.11408812318976239 0.0004976004500222433 6.103125521217082e-05 0.1105110356281192 0.03682178342614462 4.3871450233279534e-11 10.357818009135043 -0.8606446406650304 ATENDIYNFFSPLNPVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATENDIYNFFSPLNPVR 17 0 P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7;P52597 P31943;P52597 HNRNPH1;HNRNPF Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 23720100.0 6263500.0 11960000.0 5496600.0 False True 8211509.1558202775 10175614.619714854 4927864.559110269 1.0 1.2391893410363464 0.6001167952930336 22.96921596203761 -6.8053272201817805 1.433951540116406 1.1310967894840853 0.5900795548764354 0.8472958137005889 0.10302175062604851 0.2132506928937582 0.8650270310971221 0.056504203335902094 0.13101204485550805 1.5655710424940512e-07 6.8053272201817805 -0.5410172346076499 ATENDIYNFFSPLNPVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATENDIYNFFSPLNPVR 17 0 P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7;P52597 P31943;P52597 HNRNPH1;HNRNPF Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 123527000.0 50038000.0 17179000.0 56310000.0 False True 48449571.07941644 24038664.28730149 41560721.73621016 1.0 0.49615845407379044 0.8578140282828433 25.529980557832534 -9.851573094955022 5.64755255805847 1.000000105540638 0.6769862411770152 0.5154169355628303 0.14764526991217816 1.9623055078698592e-07 3.998261161069989e-08 0.14295696474169164 0.04765230595901039 1.407430327552652e-10 9.851573094955022 -0.3230138643636228 ATENDIYNFFSPLNPVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATENDIYNFFSPLNPVR 17 0 P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7;P52597 P31943;P52597 HNRNPH1;HNRNPF Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 169854000.0 10741000.0 142910000.0 16203000.0 False True 16294882.27228304 117406593.93907374 13000469.947972815 1.0 7.2051207230123895 0.7978253374733556 23.95791559310256 -6.653476055329567 1.9961251433530223 5.01540132279084 0.8247382317886408 0.2082725949886246 2.6461667228367003 0.5000620390557171 3.8230574729860747 1.073654159883976 2.93160116482067 2.22087412717342e-07 6.653476055329567 -4.190663091002199 ATENDIYNFFSPLNPVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATENDIYNFFSPLNPVR 17 0 P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7;P52597 P31943;P52597 HNRNPH1;HNRNPF Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 37054100.0 6263500.0 8198600.0 22592000.0 False True 8579285.214723006 7836358.742855357 17256234.896845195 1.0 0.913404619001044 2.0113837534194086 23.0324260235605 -6.887830645855333 1.0351535436213315 0.9378995190050744 2.1018939788629147 0.979472199907441 0.07141367530076176 0.12091995446789204 0.2322822553405878 0.05271034679437964 0.13041944566429012 1.2947006145447989e-07 6.887830645855333 1.1639944598578404 up ATENDIYNFFSPLNPVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATENDIYNFFSPLNPVR 17 0 P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7;P52597 P31943;P52597 HNRNPH1;HNRNPF Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 81346000.0 50038000.0 15340000.0 15968000.0 False True 41608814.05925585 15257360.375248412 19306834.972309843 1.0 0.36668577848722467 0.46400829749232064 25.31038583326681 -10.809250661448788 7.303546002511743 1.0236456678708887 0.41534703798977357 0.9796409009351337 0.03973175200746725 0.013743072822361481 0.00035893229090321884 0.03456067812826728 0.012823367820046979 1.5514912783296314e-11 10.809250661448788 -0.6082986298811152 ATENDIYNFFSPLNPVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATENDIYNFFSPLNPVR 17 0 P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7;P52597 P31943;P52597 HNRNPH1;HNRNPF Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 49532000.0 10741000.0 23963000.0 14828000.0 False True 13904436.236763334 22629437.984830044 12129456.148128178 1.0 1.6274976992593058 0.8723443325273333 23.72904191519501 -6.686130569388873 1.880262569010726 1.3948188176763063 0.8750751399728613 0.3523585238565248 0.2655992774201434 0.4250256137750622 2.910232098154557 0.11313534427311706 0.29604674794760166 2.0600104839233302e-07 6.686130569388873 -0.519743677703445 ATESGAQSAPLPMEGVDISPK(ub)QDEGVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATESGAQSAPLPMEGVDISPKQDEGVLK 28 1 Q02790;F5H120 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 1 276542400.0 155050000.0 118300000.0 3192400.0 True False 203272051.5063361 100650101.12978823 2862081.071663141 1.0 0.4951497285727493 0.01408005208022377 27.598836627380308 -7.952960373363731 0.563322281725696 1.0152168186308304 2.3982674974418383e-19 0.9908070290270757 0.038595446984700334 0.1095134412794217 0.1498255328578878 0.04346484829455308 0.07691601056730597 1.114396210588669e-08 7.952960373363731 -1.0152168186308304 ATESGAQSAPLPMEGVDISPK(ub)QDEGVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATESGAQSAPLPMEGVDISPKQDEGVLK 28 1 Q02790;F5H120 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 1 308624100.0 208350000.0 94374000.0 5900100.0 True False 201736043.29502395 132058030.35390848 4354686.810794059 1.0 0.654608012514568 0.021586062359841438 27.587893626081264 -7.511467130127508 0.6698530904092471 0.9961939844054919 1.1752184248801212e-16 0.9897880463309092 0.040941940816371855 0.11764300154661049 0.1259301973760697 0.03699927593391802 0.07425214931378388 3.0798734349916985e-08 7.511467130127508 -0.9961939844054918 down ATESGAQSAPLPMEGVDISPK(ub)QDEGVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATESGAQSAPLPMEGVDISPKQDEGVLK 28 1 Q02790;F5H120 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 1 287846700.0 155050000.0 129440000.0 3356700.0 True False 212376175.06870028 123720912.79916044 2563916.5934065296 1.0 0.5825555185704738 0.0120725245785086 27.6620466889032 -7.693293635471685 0.6273672756740335 1.0018283042461644 4.37315405770795e-15 0.9890257948676517 0.04241954442403123 0.1190705668327928 0.140810646267528 0.040210083807958916 0.07730541990441983 2.0263122247050798e-08 7.693293635471685 -1.00182830424616 down ATESGAQSAPLPMEGVDISPK(ub)QDEGVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATESGAQSAPLPMEGVDISPKQDEGVLK 28 1 Q02790;F5H120 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 1 354288200.0 208350000.0 143830000.0 2108200.0 True False 173252256.47000182 143055159.24198028 2549014.872784541 1.0 0.8257044505896517 0.014712736934689774 27.36829890151554 -7.1985402944755315 0.8579192528211494 0.9917166073141197 4.593326882282693e-23 0.9909184566654079 0.04091341467746337 0.09149696675187265 0.12663262489103902 0.034888993204466555 0.06503350158714488 6.330816207495799e-08 7.1985402944755315 -0.9917166073141197 down ATEVQFPVK(ub)PVVSSEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATEVQFPVKPVVSSEAK 17 1 Q9UKI8-3;Q9UKI8-4;Q9UKI8-5;Q9UKI8;Q9UKI8-2 Q9UKI8-3 TLK1 Serine/threonine-protein kinase tousled-like 1 1 11348500.0 4109600.0 3566800.0 3672100.0 True False 5319958.212326842 3368304.4445308116 3003815.4789278028 1.0 0.6331449064254178 0.5646314048045867 22.34298348288793 -13.999999999999998 0.23595988804863702 3.3815628837003615 0.5331539599439101 0.9995184864105601 0.004194337951834712 13.484278338596619 0.1537658890804639 15.09647961927668 0.034291974168168746 1.0000000000000041e-14 13.999999999999998 -2.8484089237564514 ATFCLPILGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATFCLPILGVK 11 0 O95478 O95478 NSA2 Ribosome biogenesis protein NSA2 homolog 0 11565300.0 2897900.0 3789000.0 4878400.0 False True 3799174.963303516 3223695.969406319 4373629.964917138 1.0 0.8485252720772833 1.1512051977501223 21.857254723253384 -6.770653961351743 1.5720990381705293 0.9131903062922462 1.1529438775878191 0.7330047555870197 0.06384983988792842 0.26537244888489725 1.2944907904366731 0.0320125157159585 0.07615282933446048 1.695688358716534e-07 6.770653961351743 0.23975357129557295 ATFCLPILGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATFCLPILGVK 11 0 O95478 O95478 NSA2 Ribosome biogenesis protein NSA2 homolog 0 14466800.0 2897900.0 4562900.0 7006000.0 False True 3969331.942802872 4361295.990507491 5351327.093099219 1.0 1.0987481151369367 1.348168198127687 21.920464784776275 -6.955241158847324 0.4979949902723267 0.9949168989880559 1.462720467181481 0.9995509709201852 0.003104554596643939 0.0814469763605246 0.027762336322669837 0.003654717304698588 0.020573640657474516 1.1085590739199143e-07 6.955241158847324 0.46780356819342517 ATFDISLVVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATFDISLVVPK 11 0 E9PLK3;P55786;A6NEC2;E9PP11 E9PLK3 NPEPPS;NPEPPSL1 Puromycin-sensitive aminopeptidase;Puromycin-sensitive aminopeptidase-like protein 0 4260700.0 1076100.0 1695300.0 1489300.0 False True 1410777.5209672244 1442367.8482276434 1335201.5223743622 1.0 1.0223921396470514 0.9464295415332054 20.42805906278428 -6.827755741456693 1.3377896958360582 1.0119854044395455 0.9444760795044945 0.9013175227543194 0.010011700911948461 0.18360993863288202 0.6434297222664355 0.005877022265901187 0.013527358936098887 1.4867716063083515e-07 6.827755741456693 -0.06750932493505102 ATFDISLVVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATFDISLVVPK 11 0 E9PLK3;P55786;A6NEC2;E9PP11 E9PLK3 NPEPPS;NPEPPSL1 Puromycin-sensitive aminopeptidase;Puromycin-sensitive aminopeptidase-like protein 0 7476500.0 2816100.0 1873200.0 2787200.0 False True 2726704.446955203 2621178.5286089526 2057148.705792307 1.0 0.961299099187634 0.7544450620929741 21.37872690139986 -6.938328620400333 0.6749333091163856 1.0024026894298625 0.7013029202004407 0.9979366826248522 0.00489658404985907 0.08853749527615427 0.05814441003337337 0.0047081290942011834 0.01793857990190664 1.1525807970488362e-07 6.938328620400333 -0.30109976922942183 ATFDISLVVPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATFDISLVVPK 11 0 E9PLK3;P55786;A6NEC2;E9PP11 E9PLK3 NPEPPS;NPEPPSL1 Puromycin-sensitive aminopeptidase;Puromycin-sensitive aminopeptidase-like protein 0 39975900.0 8969900.0 13602000.0 17404000.0 False True 13607994.087529246 11174616.82708892 13964091.77155581 1.0 0.8211803117499631 1.026168271512765 23.6979510834961 -6.676156652523416 1.915585221131167 0.886470933788662 1.0253657665945433 0.3066222366692666 0.07585246542809387 0.44710821452075317 3.168601927940613 0.03181320322984414 0.08431928761024897 2.1078676927618367e-07 6.676156652523416 0.13889483280588122 ATFDISLVVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATFDISLVVPK 11 0 E9PLK3;P55786;A6NEC2;E9PP11 E9PLK3 NPEPPS;NPEPPSL1 Puromycin-sensitive aminopeptidase;Puromycin-sensitive aminopeptidase-like protein 0 4754300.0 1076100.0 813900.0 2864300.0 False True 1473963.2505090502 777939.2067926194 2187811.332110205 1.0 0.5277873831141646 1.4843052100210907 20.49126912430717 -6.772435279206461 1.564891999278952 0.7300051996124988 1.4902236549866024 0.7399156768030313 0.1991526544486569 0.2624856271541148 1.268869468875573 0.10028747139599027 0.23821991412495683 1.688747506559566e-07 6.772435279206461 0.7602184553741036 ATFDISLVVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATFDISLVVPK 11 0 E9PLK3;P55786;A6NEC2;E9PP11 E9PLK3 NPEPPS;NPEPPSL1 Puromycin-sensitive aminopeptidase;Puromycin-sensitive aminopeptidase-like protein 0 6391800.0 2816100.0 1357500.0 2218200.0 False True 2341711.924382874 1350186.8780573483 2682015.3642020063 1.0 0.5765811174289389 1.1453225037101071 21.159132176834138 -6.707387878492641 1.8046380407124591 0.7389945856737676 1.143877991186 0.4526002533127612 0.17850170477698665 0.380366980883314 2.4130936663691243 0.07876487396906016 0.2007270312918543 1.961607536976889e-07 6.707387878492641 0.40488340551223234 ATFDISLVVPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATFDISLVVPK 11 0 E9PLK3;P55786;A6NEC2;E9PP11 E9PLK3 NPEPPS;NPEPPSL1 Puromycin-sensitive aminopeptidase;Puromycin-sensitive aminopeptidase-like protein 0 25210800.0 8969900.0 8688100.0 7552800.0 False True 11611712.373162966 8204599.597546302 6178267.898272363 1.0 0.7065796442313541 0.5320720751361012 23.46907740558855 -10.287234023537303 0.09213150411507519 1.8593764471821699 3.4269857274581664e-13 0.9999403816281945 0.0014907849631278513 2.0478593861322083 0.0469585539480547 0.6936105564031763 0.2972503469493387 5.1613816856998234e-11 10.287234023537303 -1.8593764471818273 ATFIK(ub)VPQNQNGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATFIKVPQNQNGK 13 1 P19338;H7BY16 P19338 NCL Nucleolin 1 30575800.0 6831800.0 14329000.0 9415000.0 True False 8956555.959245315 12191169.054004546 8440826.11505717 1.0 1.3611447424074132 0.9424187325424135 23.094512652533883 -6.678596057570552 1.9077731049216529 1.2287996614363745 0.9440634507632272 0.31735748263635766 0.1531107430397434 0.441623608256961 3.1066411749328773 0.06444091203453967 0.17020895952030815 2.0960611206887205e-07 6.678596057570552 -0.28473621067314736 ATFIK(ub)VPQNQNGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATFIKVPQNQNGK 13 1 P19338;H7BY16 P19338 NCL Nucleolin 1 39360100.0 9580100.0 11203000.0 18577000.0 True False 9275984.96938162 15676416.32287322 13711126.401945923 1.0 1.6900001859229277 1.4781315889583606 23.145069051596128 -10.330069709379258 5.209679299776126 0.999811053054949 1.5840658874406937 0.9101752937834404 0.08649499251393493 0.00018988120014938145 2.4417315296083862e-05 0.08377507111979746 0.027916138794708813 4.676600703133104e-11 10.330069709379258 0.5842548343857447 ATFIK(ub)VPQNQNGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATFIKVPQNQNGK 13 1 P19338;H7BY16 P19338 NCL Nucleolin 1 47143000.0 11265000.0 10423000.0 25455000.0 True False 17089828.581814386 8562934.2147293 20423808.09267714 1.0 0.5010544239069362 1.1950856028135066 24.026634590458674 -6.713756075074528 1.7816114881263991 0.6944466948086029 1.1936570134521136 0.4830049571060515 0.2101338204034104 0.36758049598606485 2.2765741155310746 0.09377574454402317 0.23717390524556825 1.9330537270653487e-07 6.713756075074528 0.49921031864351073 ATFIK(ub)VPQNQNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATFIKVPQNQNGK 13 1 P19338;H7BY16 P19338 NCL Nucleolin 1 23759400.0 6831800.0 8735900.0 8191700.0 True False 9357701.082453053 8349919.052241851 6256989.173357242 1.0 0.8923045285020987 0.6686459759961704 23.157722714056774 -6.959301431961247 0.44516935826702103 1.0075794590749194 0.5445756457730049 0.9997434058242515 0.002210688468997032 0.07995159999718873 0.022060485278123775 0.00296882008611379 0.018514397309818655 1.0982433140923366e-07 6.959301431961247 -0.46300381330191454 ATFIK(ub)VPQNQNGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATFIKVPQNQNGK 13 1 P19338;H7BY16 P19338 NCL Nucleolin 1 37734800.0 9580100.0 21366000.0 6788700.0 True False 7966277.620390044 21250897.117181063 8208185.782597685 1.0 2.667606896198099 1.0303665242080526 22.925474327030404 -6.641919887233151 2.0376690141465863 2.088933477834801 1.0372136084508274 0.16197502353779092 0.713179112888839 0.5285277285900265 4.196552454554896 0.2847977844755216 0.7896703558062698 2.2807627574361835e-07 6.641919887233151 -1.0517198693839735 ATFIK(ub)VPQNQNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATFIKVPQNQNGK 13 1 P19338;H7BY16 P19338 NCL Nucleolin 1 41684000.0 11265000.0 13445000.0 16974000.0 True False 14582764.566347534 12696773.930895146 13884906.167947643 1.0 0.8706698838295267 0.9521449862798765 23.797760912551123 -10.308904662705203 4.9681911471832905 1.0000326514564593 0.9114074350555873 0.6118708182231085 0.0332620712908457 1.2034059361595933e-05 1.673976691793076e-06 0.03221772733373193 0.010735287347466635 4.910156531754629e-11 10.308904662705203 -0.08862521640087195 ATFMVGSYGPRPEEYEFLTPVEEAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATFMVGSYGPRPEEYEFLTPVEEAPK 26 1 P52566;H0YGX7 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 10885500.0 2902100.0 6128600.0 1854800.0 False True 3804681.2039763816 5214236.769095696 1662883.0884979311 1.0 1.3704792831646833 0.4370623974381886 21.859344144022646 -6.799039240076144 1.4600667589837202 1.2046626831216838 0.4245164254059004 0.8292588637482221 0.15857134410900686 0.22214246429264706 0.935062292328997 0.08544753893819684 0.1988161821511375 1.588403224141509e-07 6.799039240076144 -0.7801462577157834 down ATFMVGSYGPRPEEYEFLTPVEEAPK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ATFMVGSYGPRPEEYEFLTPVEEAPK 26 1 P52566;H0YGX7 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 69155300.0 24544700.0 16649900.0 27960700.0 False True 23765541.933589526 23298291.89808144 20636953.866980143 1.0 0.9803391802798451 0.8683561235274199 24.50236796448371 -6.936949351155512 0.68738873846311 1.0013477682061231 0.8406909766396653 0.9977359383617903 0.0027588867237556707 0.08918703968327359 0.061163618834291875 0.002627079830031884 0.009774769135093975 1.1562470796496763e-07 6.936949351155512 -0.16065679156645785 ATFMVGSYGPRPEEYEFLTPVEEAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATFMVGSYGPRPEEYEFLTPVEEAPK 26 1 P52566;H0YGX7 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 49261600.0 8743300.0 33797000.0 6721300.0 False True 13264225.320850208 27765661.292833745 5392832.108949564 1.0 2.093274248680663 0.4065696999637439 23.661037083584873 -6.731745548487633 1.7168737567567454 1.656648927351389 0.4072543009407337 0.5673219956478832 0.459527094962719 0.3329833865748511 1.9236721893369915 0.21203669688822652 0.525116445958206 1.8546179188565437e-07 6.731745548487633 -1.2493946264106552 ATFMVGSYGPRPEEYEFLTPVEEAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATFMVGSYGPRPEEYEFLTPVEEAPK 26 1 P52566;H0YGX7 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 14651900.0 2902100.0 4622500.0 7127300.0 False True 3975084.796303612 4418262.66543665 5443978.531351135 1.0 1.1114889095058158 1.3695251322470985 21.922554205545538 -6.957092193086445 0.4746426442215042 0.9934831417634806 1.4981922267028718 0.9996466867206663 0.002908996911400495 0.08075666958753708 0.02509691918708279 0.00359964123531626 0.02129091668264256 1.1038442682888105e-07 6.957092193086445 0.5047090849393912 ATFMVGSYGPRPEEYEFLTPVEEAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATFMVGSYGPRPEEYEFLTPVEEAPK 26 1 P52566;H0YGX7 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 34929800.0 18622000.0 8388300.0 7919500.0 False True 15485018.094477441 8343110.562952822 9575430.834369209 1.0 0.5387859744205464 0.618367429469403 23.884369733036035 -10.774592612051029 7.075091287303571 1.0107137299409483 0.5785767019449748 0.9739513506833611 0.03248899297632247 0.005463652075186069 0.00017406783708034734 0.03130358421481183 0.010485777394362229 1.6803795513854454e-11 10.774592612051029 -0.43213702799597353 ATFMVGSYGPRPEEYEFLTPVEEAPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATFMVGSYGPRPEEYEFLTPVEEAPK 26 1 P52566;H0YGX7 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 63509000.0 18412000.0 28647000.0 16450000.0 False True 23834696.954779506 27052769.267263155 13456268.791253619 1.0 1.1350162881696861 0.56456638894061 24.50655994665222 -6.844299576880268 1.2623769159452933 1.0718340815158358 0.5441612830561326 0.9315792282737423 0.06367018170093723 0.16383963325514841 0.5053249941197275 0.03951924952216868 0.0911723184530442 1.4312003149155395e-07 6.844299576880268 -0.5276727984597032 ATFMVGSYGPRPEEYEFLTPVEEAPK(ub)GMLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATFMVGSYGPRPEEYEFLTPVEEAPKGMLAR 31 2 P52566;H0YGX7 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 85556000.0 9592000.0 17923000.0 58041000.0 True False 14551765.269131258 14724500.616961857 46569170.90972603 1.0 1.0118704050426806 3.2002420358245796 23.794690840750107 -6.908089802802319 0.9086406259138912 0.9280826279959874 3.4717984553273085 0.9901806282274731 0.10250326888873758 0.10569487912791274 0.14571783975451855 0.08313611488306794 0.22656781943450596 1.2356918923931723e-07 6.908089802802319 2.543715827331321 up ATFMVGSYGPRPEEYEFLTPVEEAPK(ub)GMLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATFMVGSYGPRPEEYEFLTPVEEAPKGMLAR 31 2 P52566;H0YGX7 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 80698000.0 9592000.0 17209000.0 53897000.0 True False 12417033.086587265 16251304.022073213 44088299.02992074 1.0 1.3087912312666448 3.550630712061516 23.565817162842556 -6.931948817916539 0.7306232190200054 0.9682518622588857 4.034566227040828 0.9969074755400956 0.06320734267282076 0.09163871808165108 0.07281634922794651 0.05826713361581264 0.20071867664235674 1.1696372259342038e-07 6.931948817916539 3.066314364781942 up ATFYGEQVDYYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATFYGEQVDYYK 12 0 P46940;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 9358400.0 1634100.0 3430500.0 4293800.0 False True 2142320.924646912 2918682.7719842643 3849518.7650379604 1.0 1.3623928788658537 1.7968917358506504 21.030743184667198 -6.968712175065509 0.2872862807708031 0.9122985626770783 2.260359663527999 0.999970521546867 0.0017687462948680224 0.07672283966173395 0.010518560744050854 0.007703560039435373 0.03952768856241586 1.0747014255060201e-07 6.968712175065509 1.3480611008509207 ATFYGEQVDYYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATFYGEQVDYYK 12 0 P46940;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 8572900.0 1634100.0 3285100.0 3653700.0 False True 2238270.9298920543 3139953.419627022 2790771.310313535 1.0 1.4028477865181646 1.2468424948217176 21.09395324619009 -10.166773224692706 5.272846159660397 0.9999868719636007 1.3248451406700836 0.852531977827456 0.06368889363888913 9.829393349522969e-06 1.5534001836832637e-06 0.06166899666441565 0.02055550203341089 6.811249284756824e-11 10.166773224692706 0.32485826870648293 ATFYGEQVDYYK(ub)SYIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATFYGEQVDYYKSYIK 16 1 P46940;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 22844800.0 7666400.0 7868500.0 7309900.0 True False 7423034.3283751905 11010433.083685424 5395217.897700634 1.0 1.4832792893866988 0.726821089467005 22.82357761003213 -6.7341146295363945 1.7080632643446816 1.2894895412415857 0.7269066196670366 0.5783201045789376 0.20310181764862836 0.32856986322633114 1.8797312486946551 0.09415660034333176 0.2325774320240812 1.8445285022090956e-07 6.7341146295363945 -0.562582921574549 ATFYGEQVDYYK(ub)SYIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATFYGEQVDYYKSYIK 16 1 P46940;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 55971000.0 20759000.0 16483000.0 18729000.0 True False 31492920.686185993 13541479.867733177 15027204.940787703 1.0 0.42998488462434004 0.4771613624067333 24.908524224926552 -10.052599405013382 7.686441800006756 1.00000002853596 0.45357312512182024 0.9944406108437432 0.01925971640476855 9.4122710011655e-09 1.1749346243507584e-09 0.018648141194658144 0.006216046740695545 8.859324207061206e-11 10.052599405013382 -0.5464269034141398 ATFYGEQVDYYK(ub)SYIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATFYGEQVDYYKSYIK 16 1 P46940;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 19743700.0 7666400.0 7791300.0 4286000.0 True False 6374951.279105455 7749326.720448026 5182182.7837750465 1.0 1.2155899521690818 0.8128976296274095 22.603982885466408 -6.761248939546695 1.6075426258090293 1.125028890157071 0.8113225313829221 0.6961573182098555 0.09069514789832209 0.28081108669234206 1.4304632868595948 0.04450675629455554 0.10683493057472665 1.7328104582969422e-07 6.761248939546695 -0.313706358774149 ATFYGEQVDYYK(ub)SYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATFYGEQVDYYKSYIK 16 1 P46940;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 49109700.0 20759000.0 18647000.0 9703700.0 True False 26872934.72106602 17609278.057969633 7937726.168370073 1.0 0.6552793076286345 0.2953799520134879 24.679650547019 -7.358239540511474 0.30252690596520143 1.0784962415164032 9.067147675755833e-13 0.9998162595109614 0.003899553781588573 0.11166727227826977 0.024088653292526428 0.015749751054398707 0.05389163101675524 4.3828888741895425e-08 7.358239540511474 -1.0784962415154966 down ATFYLLIGNANAAKPDLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATFYLLIGNANAAKPDLDK 19 1 O94826 O94826 TOMM70A Mitochondrial import receptor subunit TOM70 0 10806700.0 5605100.0 2531800.0 2669800.0 False True 5427169.168576623 3542760.9431625814 1970499.287716816 1.0 0.652782478879636 0.363080498600639 22.371768448496983 -7.522738952822497 0.22284263242971658 1.1675609813494725 7.314009355692813e-15 0.9999146682008935 0.002405207604894029 0.1288692887125398 0.02201821334130074 0.030995463647212097 0.06728557943958162 3.00096580751928e-08 7.522738952822497 -1.1675609813494652 down ATFYLLIGNANAAKPDLDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATFYLLIGNANAAKPDLDK 19 1 O94826 O94826 TOMM70A Mitochondrial import receptor subunit TOM70 0 37885000.0 11053000.0 10737000.0 16095000.0 False True 16768209.082538346 8820898.461436098 12913816.19531089 1.0 0.526048930927381 0.7701368781689844 23.999225275253725 -10.085942411364298 4.941713355747229 1.0000107008277017 0.648092904546141 0.7348477769579325 0.09964848719128516 1.1748349063918839e-05 2.173140380609476e-06 0.09648716582302504 0.03216141094620831 8.204603324001517e-11 10.085942411364298 -0.3519177962815607 ATFYLLIGNANAAKPDLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATFYLLIGNANAAKPDLDK 19 1 O94826 O94826 TOMM70A Mitochondrial import receptor subunit TOM70 0 7809800.0 1848300.0 1904100.0 4057400.0 False True 2531666.458429399 1819970.5659833257 3099125.684776019 1.0 0.7188824420071526 1.2241445449724295 21.271655914664326 -6.755698025003293 1.6286964384137148 0.835840691915941 1.2256061096759558 0.6731518309275668 0.11817687496000165 0.2902039016002389 1.5161724573844273 0.057278747971580536 0.13823912504933233 1.7551004395910243e-07 6.755698025003293 0.38976541776001483 ATFYLLIGNANAAKPDLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATFYLLIGNANAAKPDLDK 19 1 O94826 O94826 TOMM70A Mitochondrial import receptor subunit TOM70 0 11051800.0 5605100.0 1976900.0 3469800.0 False True 4660888.998032195 1966250.0473160725 4195319.137457453 1.0 0.42186159081372976 0.9001113605641964 22.15217372393126 -10.11572125029797 7.487728621473669 1.0000000810919456 0.6609864756889705 0.4011912113588517 0.1952446509153641 2.642740148427573e-07 3.1225765925740273e-08 0.1890448654292523 0.06301494011927382 7.660881589286267e-11 10.11572125029797 -0.3390136054029751 ATFYLLIGNANAAKPDLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATFYLLIGNANAAKPDLDK 19 1 O94826 O94826 TOMM70A Mitochondrial import receptor subunit TOM70 0 33195200.0 11053000.0 13408000.0 8734200.0 False True 14308326.38720278 12661833.013420753 7144665.22046002 1.0 0.8849276058411252 0.49933619258574746 23.770351597346174 -6.948941426556546 0.5703475704904993 1.0047957815491952 0.360709677505668 0.9991155652763134 0.006367501279640051 0.08391363776410728 0.03774329281600354 0.0067433063631762305 0.032130077479972353 1.1247566600483386e-07 6.948941426556546 -0.6440861040435273 down ATFYLNVLEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATFYLNVLEQK 11 0 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 0 105249000.0 23020000.0 41358000.0 40871000.0 False True 34923022.98742717 33977341.76847108 32792828.935604308 1.0 0.9729209805435071 0.9390031598183879 25.057675110355476 -6.968088125895096 0.30053501720202624 1.0058452394614212 0.9050155836304017 0.999963238202332 0.00015118950134672402 0.0769297125283415 0.011248446496570669 0.0005612174163028617 0.00304017751999373 1.07624680229773e-07 6.968088125895096 -0.10082965583101955 ATFYLNVLEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATFYLNVLEQK 11 0 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 0 72774000.0 23020000.0 29846000.0 19908000.0 False True 29799843.792039067 28185043.86325746 16284948.273329912 1.0 0.9458117988788587 0.5464776388418648 24.828801432447925 -6.931657686443665 0.7330629715208816 1.0057148425036277 0.46092642944046597 0.9968539972270529 0.011343139720204882 0.09178645928852985 0.0735317111291468 0.010437910132192703 0.03580926327611523 1.170421560946635e-07 6.931657686443665 -0.5447884130631617 ATFYLNVLEQK(ub)QK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATFYLNVLEQKQK 13 1 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 1 14331500.0 5547200.0 4870600.0 3913700.0 True False 4612742.582627278 4844361.111061591 4732036.575095749 1.0 1.050212758307096 1.0258618360620777 22.137193353353737 -10.244822110529459 4.74119580681847 0.9999900054463217 1.0380372971846896 0.7648896604589237 0.009941222378100403 1.0505274746544406e-06 1.67337455540731e-07 0.009628076321199342 0.003208515725893849 5.6908598394106505e-11 10.244822110529459 0.03804729173836796 ATFYLNVLEQKQK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATFYLNVLEQKQK 13 1 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 1 9817100.0 1785800.0 5355400.0 2675900.0 True False 2341201.0937117985 4556395.195185698 2399023.5370452977 1.0 1.9461784839515324 1.024697768802861 21.158817427072197 -6.640064408024132 2.0445227524404017 1.618739063223167 1.0285569082544934 0.15468739467049164 0.4048404886310596 0.5332519050366438 4.260362432231948 0.16125778035444044 0.44821075249888054 2.2905279309326288e-07 6.640064408024132 -0.5901821549686737 ATFYLNVLQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATFYLNVLQQR 11 0 Q9UBF2;Q9UBF2-2 Q9UBF2 COPG2 Coatomer subunit gamma-2 0 8241300.0 1871100.0 2913300.0 3456900.0 False True 2453030.2197581762 2478646.995954459 3099213.148926297 1.0 1.0104429109718869 1.263422327194902 21.22613357640628 -6.915583365831999 0.8568538739984604 0.9934812952305174 1.3003416503320973 0.9928632264221499 0.010288891345123152 0.10084068860087228 0.11959977850562925 0.008663487169188987 0.024949531073186 1.214553456150107e-07 6.915583365831999 0.30686035510157983 ATFYLNVLQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATFYLNVLQQR 11 0 Q9UBF2;Q9UBF2-2 Q9UBF2 COPG2 Coatomer subunit gamma-2 0 8729700.0 3007600.0 2784600.0 2937500.0 False True 2912125.3842770043 3896505.3014971605 2168080.6268889564 1.0 1.3380279992527 0.7445011257395524 21.473641042779864 -6.752180772341685 1.6414685307836105 1.1982330560359304 0.7430982110897314 0.6584733963158599 0.14206006910360358 0.29623176328537115 1.5709952671357357 0.06834371164893485 0.16556186165652712 1.7693723149388613e-07 6.752180772341685 -0.45513484494619905 ATFYLNVLQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATFYLNVLQQR 11 0 Q9UBF2;Q9UBF2-2 Q9UBF2 COPG2 Coatomer subunit gamma-2 0 10186100.0 1871100.0 2788300.0 5526700.0 False True 2562896.2345762327 2665103.6863249317 4221407.285959389 1.0 1.039879668310332 1.6471237613946497 21.28934363792917 -6.920240440180934 0.8229225534574934 0.9867185645849208 1.745597518347718 0.9942481047861607 0.022456992536612586 0.09802967301910914 0.10487547329028013 0.019373917390779954 0.058169839654581015 1.2015990043972068e-07 6.920240440180934 0.7588789537627971 ATFYLNVLQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATFYLNVLQQR 11 0 Q9UBF2;Q9UBF2-2 Q9UBF2 COPG2 Coatomer subunit gamma-2 0 8469000.0 3007600.0 1856200.0 3605200.0 False True 2500952.6592713096 1846200.2821731488 4359030.651438591 1.0 0.7381988120922958 1.742948086313901 21.25404631821414 -6.83749726073381 1.293983278798128 0.8606522134334824 1.7743879908274447 0.9200629834908132 0.1203236194445906 0.17174173254342498 0.5596753155786602 0.07294312576389236 0.16794959216782607 1.453793555226758e-07 6.83749726073381 0.9137357773939623 ATGDETGAK(ub)VER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATGDETGAKVER 12 1 P61247;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 7405300.0 2252000.0 3317600.0 1835700.0 True False 2952393.808399022 2822627.011903515 1645759.3732777957 1.0 0.9560469216110858 0.5574321991178516 21.49345373907319 -6.927841067312931 0.7643115876681953 1.0065721440050863 0.4799246977284542 0.996096500505774 0.012438051263862172 0.09377470146993173 0.08328827636929309 0.011189356095380923 0.036505391092224226 1.1807526601589687e-07 6.927841067312931 -0.5266474462766322 ATGDETGAK(ub)VER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATGDETGAKVER 12 1 P61247;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 6960600.0 2786600.0 2682100.0 1491900.0 True False 2698140.9083077186 3753076.5169667276 1101126.6339593655 1.0 1.3909861065487004 0.4081056814226931 21.363534263202794 -6.7987911712016125 1.4611050191782633 1.2160564751387855 0.3949798902440179 0.8285274732478851 0.16731149600097708 0.2224918535623108 0.9378932308177815 0.0900951436427767 0.20965988831318902 1.5893107787475374e-07 6.7987911712016125 -0.8210765848947675 down ATGDETGAK(ub)VER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATGDETGAKVER 12 1 P61247;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 27038700.0 10461400.0 8509300.0 8068000.0 True False 15870708.63078502 6990748.931535646 6473356.263669975 1.0 0.4404812093881822 0.4078807326292513 23.91986321048767 -13.913635531030328 0.405202631724667 9.999900317258303 0.4061763074310121 0.999843650929079 0.003398194091021711 25.586421684483692 0.21021349050270433 202.31233833069146 0.008227214551951453 1.2200130297534513e-14 13.913635531030328 -9.593724009827291 ATGDETGAK(ub)VER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATGDETGAKVER 12 1 P61247;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 15318900.0 2252000.0 11045000.0 2021900.0 True False 3084625.25801169 10556995.379069293 1544368.862337611 1.0 3.4224563750976342 0.5006666071758393 21.55666380059608 -6.686509967980171 1.8784927834887986 2.5235601262849996 0.5110162841541461 0.35445302785377997 1.0252456554962177 0.4241108819681418 2.8987004507197236 0.4370386287463928 1.1432473940984573 2.058211649673904e-07 6.686509967980171 -2.0125438421308535 ATGDETGAK(ub)VER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATGDETGAKVER 12 1 P61247;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 7655070.0 2786600.0 3862970.0 1005500.0 True False 2317181.3673112867 3842159.4138704934 1215745.4010932837 1.0 1.6581176890476623 0.5246656210186771 21.14393953863707 -6.749289654428159 1.652404959866443 1.3873127268138272 0.5225273863674635 0.6459184923371204 0.27653709268052545 0.3012951525932738 1.6183703232165714 0.13221307264685372 0.3212259994488453 1.7811903991934644e-07 6.749289654428159 -0.8647853404463637 ATGDETGAK(ub)VER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATGDETGAKVER 12 1 P61247;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 21754900.0 10461400.0 6253300.0 5040200.0 True False 13542488.525023371 5905298.35790751 4122935.3168192375 1.0 0.4360571062693457 0.3044444386422046 23.69098953258012 -13.999999999999993 0.20442314539230155 4.189045728128886 0.22260013839748538 0.9994876512427088 0.006828784726716659 12.621871855784672 0.1433421393608629 16.125039018991757 0.08112227804525254 1.0000000000000164e-14 13.999999999999993 -3.966445589731401 ATGEGFVEFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATGEGFVEFR 10 0 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 0 5649000.0 1611700.0 2263400.0 1773900.0 False True 2112954.307725003 1925709.5426640965 1590353.844450333 1.0 0.9113824826328066 0.7526683556932432 21.010830138901195 -6.962144773871199 0.40407541411719156 1.008342055528426 0.6498752065243228 0.9998416498771007 0.0012874973073704035 0.07894372332460299 0.018364797611507017 0.002041819317591044 0.013277997769172729 1.0910765609111578e-07 6.962144773871199 -0.3584668490041031 ATGFDGGNK(ub)ADQLDYENFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATGFDGGNKADQLDYENFR 19 1 Q8NI27;A0A0C4DG98;H0Y815 Q8NI27 THOC2 THO complex subunit 2 1 11502500.0 2873900.0 4259200.0 4369400.0 True False 3767710.7308871867 3623743.9622315657 3917296.402244374 1.0 0.9617893254183766 1.0397020052868986 21.845256774419656 -6.773313940517078 1.561496671705313 0.9781771012058723 1.0401993020665428 0.7432067262108546 0.016119472900622857 0.26108398208085093 1.2567266900597196 0.008134333278995418 0.01930699335653271 1.685334299330426e-07 6.773313940517078 0.06202220086067045 ATGFDGGNK(ub)ADQLDYENFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATGFDGGNKADQLDYENFR 19 1 Q8NI27;A0A0C4DG98;H0Y815 Q8NI27 THOC2 THO complex subunit 2 1 11477200.0 2664400.0 2994200.0 5818600.0 True False 2579820.080418823 4189799.674546728 4294534.10574165 1.0 1.6240666185785064 1.664664190475039 21.298839023291062 -11.389035052960722 0.4563530423277324 5.0199523424311867e-23 1.6646051783107079 0.9997713855506213 0.004599630747434372 3.7538882103598366 0.22497346818683678 3.756662542032412 0.009025683300144537 4.082864312148804e-12 11.389035052960722 1.6646051783107079 ATGFDGGNK(ub)ADQLDYENFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATGFDGGNKADQLDYENFR 19 1 Q8NI27;A0A0C4DG98;H0Y815 Q8NI27 THOC2 THO complex subunit 2 1 31686400.0 7258900.0 8350500.0 16077000.0 True False 11012281.996673996 6860288.03224571 12899373.903200565 1.0 0.6229669776271349 1.1713624757426773 23.392610123499754 -6.721668288266191 1.753220144271018 0.7710344444277094 1.1705964959887718 0.5204828755763911 0.15862434185164026 0.3520543431216075 2.115714859875556 0.07181329622758942 0.17993173767854984 1.898155168142401e-07 6.721668288266191 0.3995620515610624 ATGFDGGNK(ub)ADQLDYENFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATGFDGGNKADQLDYENFR 19 1 Q8NI27;A0A0C4DG98;H0Y815 Q8NI27 THOC2 THO complex subunit 2 1 13034400.0 2873900.0 3489400.0 6671100.0 True False 3936458.4942272604 3335226.770097271 5095523.57561721 1.0 0.8472658291681002 1.2944436180616907 21.908466835942548 -6.8145164091870205 1.3952729604130045 0.9171890257007278 1.3031147413024817 0.8713109443206312 0.06657716783596775 0.20072422445674082 0.7692326919271428 0.03750812794870602 0.08660824770432879 1.532793290897757e-07 6.8145164091870205 0.3859257156017539 ATGFDGGNK(ub)ADQLDYENFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATGFDGGNKADQLDYENFR 19 1 Q8NI27;A0A0C4DG98;H0Y815 Q8NI27 THOC2 THO complex subunit 2 1 12775700.0 2664400.0 4749000.0 5362300.0 True False 2215566.652933395 4723416.194397308 6483532.137526107 1.0 2.1319224082667687 2.92635390993178 21.07924429872534 -7.969449004472002 0.16942713153747993 5.537957978906865e-21 4.271585511162215 0.9999195769768344 0.00708860728047995 0.11185078913397947 0.02878659001738471 0.2785652128800375 0.35717125555463564 1.0728796196194194e-08 7.969449004472002 4.271585511162215 ATGFDGGNK(ub)ADQLDYENFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATGFDGGNKADQLDYENFR 19 1 Q8NI27;A0A0C4DG98;H0Y815 Q8NI27 THOC2 THO complex subunit 2 1 32143900.0 7258900.0 5604000.0 19281000.0 True False 9396789.144310715 5292132.4736880865 15772055.83976664 1.0 0.563185189367818 1.6784516069849063 23.163736445592203 -6.800467055914604 1.4539534336330253 0.7591304788881982 1.694033497156009 0.8335336922295145 0.18721372983816728 0.22009516144235228 0.918514690756118 0.10129280923708307 0.23550844711656635 1.5831896574726867e-07 6.800467055914604 0.9349030182678107 ATGILLYGLASR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATGILLYGLASR 12 0 P47897;P47897-2;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9;A0A0U1RQU2;A0A0U1RQL2;F2Z2V6 P47897 QARS Glutamine--tRNA ligase 0 83111900.0 19315900.0 40481000.0 23315000.0 False True 29303632.48144417 33256849.270503353 18706780.03067246 1.0 1.1349053497569785 0.638377513180937 24.80457617657721 -6.834343418175557 1.308528784909467 1.0718948031591717 0.62380446861668 0.9142594247349867 0.061383375533553164 0.17551370646662243 0.586211274811917 0.03681561423184695 0.08472449445503986 1.4643894177000777e-07 6.834343418175557 -0.4480903345424917 ATGILLYGLASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATGILLYGLASR 12 0 P47897;P47897-2;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9;A0A0U1RQU2;A0A0U1RQL2;F2Z2V6 P47897 QARS Glutamine--tRNA ligase 0 68834900.0 19315900.0 19773000.0 29746000.0 False True 25004813.323312234 18672615.168136094 24332533.21973433 1.0 0.7467608306728462 0.9731139723026394 24.57570249866966 -10.298348051290478 7.262342950381175 1.0000011237898336 0.8599374016009775 0.3379749246123489 0.09240828311148776 1.6813761773221266e-06 1.6247634232606687e-07 0.08947465265583887 0.02982464512853436 5.030972561300601e-11 10.298348051290478 -0.1400637221888561 ATGISFAIHGNFSGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATGISFAIHGNFSGTK 16 0 Q15393;Q15393-2;I3L4G7;H3BMB0 Q15393 SF3B3 Splicing factor 3B subunit 3 0 15923200.0 5314900.0 5382000.0 5226300.0 False True 6967885.369564814 4579026.578871685 4685532.610209591 1.0 0.6571615828917795 0.6724468560685049 22.73228945931711 -10.031754906520964 7.330321276516764 1.000000026776312 0.6648042194861135 0.9984428366833633 0.006240186643671444 2.728349913342298e-09 3.561872614760533e-10 0.006042035187206733 0.002014011579013767 9.294907956123788e-11 10.031754906520964 -0.3351958072901986 ATGISFAIHGNFSGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATGISFAIHGNFSGTK 16 0 Q15393;Q15393-2;I3L4G7;H3BMB0 Q15393 SF3B3 Splicing factor 3B subunit 3 0 16939500.0 10984000.0 5955500.0 0.0 False True 10635318.93233763 8333562.20752222 0.0 1.0 0.7835742642548579 0.0 23.342359961751093 -7.276939757304155 0.8339629885623172 0.9890163965014735 1.4039277952883724e-17 0.9885277246197214 0.046011452940869314 0.10140474543388155 0.1376427647695271 0.03911593038306449 0.0690534960698541 5.285185595789377e-08 7.276939757304155 -0.9890163965014735 down ATGISFAIHGNFSGTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATGISFAIHGNFSGTK 16 0 Q15393;Q15393-2;I3L4G7;H3BMB0 Q15393 SF3B3 Splicing factor 3B subunit 3 0 218976000.0 45540000.0 71566000.0 101870000.0 False True 69087509.41995803 58794488.152289875 81735349.84879293 1.0 0.8510147296655233 1.1830698564041908 26.041921568359868 -6.784772726898914 1.5175957426873043 0.9161618147187779 1.186089078074718 0.7837975585733237 0.0631431407679433 0.24323756653906153 1.1067731265718592 0.032763550156597446 0.07699522806155505 1.6414485441951852e-07 6.784772726898914 0.2699272633559401 ATGISFAIHGNFSGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATGISFAIHGNFSGTK 16 0 Q15393;Q15393-2;I3L4G7;H3BMB0 Q15393 SF3B3 Splicing factor 3B subunit 3 0 25243200.0 5314900.0 6909300.0 13019000.0 False True 7279962.159771904 6604024.280000302 9944180.33472149 1.0 0.9071509075271373 1.365965937250567 22.79549952084 -6.854048112718833 1.215548183576504 0.950227911059273 1.3857747501591984 0.9459694682536882 0.04603886643034163 0.15306409478659866 0.43320310081921964 0.02960475029615825 0.06870204779929083 1.3994322797979446e-07 6.854048112718833 0.4355468390999254 ATGISFAIHGNFSGTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATGISFAIHGNFSGTK 16 0 Q15393;Q15393-2;I3L4G7;H3BMB0 Q15393 SF3B3 Splicing factor 3B subunit 3 0 23815000.0 10984000.0 4941100.0 7889900.0 False True 9133682.673705313 4914481.313568442 9539641.611224147 1.0 0.5380613153680712 1.0444463588260555 23.12276523718537 -6.666657253130298 1.9490828096842434 0.7043046347596567 1.0423783413412027 0.2643661353678347 0.19637370836116752 0.4688497831079496 3.430501570760937 0.08120170277795576 0.21791176399178017 2.1544813889192838e-07 6.666657253130298 0.338073706581546 ATGISFAIHGNFSGTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATGISFAIHGNFSGTK 16 0 Q15393;Q15393-2;I3L4G7;H3BMB0 Q15393 SF3B3 Splicing factor 3B subunit 3 0 169806000.0 45540000.0 68592000.0 55674000.0 False True 58952427.727604665 64774794.90278618 45541903.26348043 1.0 1.098763823639025 0.7725195554950027 25.813047890452317 -6.825513365898225 1.3479287671667575 1.052956961794591 0.7645237472442947 0.8965811422787896 0.04392904522521761 0.1864141753279606 0.663974785149762 0.02560003981545062 0.058933202182311364 1.494468047733697e-07 6.825513365898225 -0.28843321455029636 ATGISFAIHGNFSGTK(ub)QQEIVVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATGISFAIHGNFSGTKQQEIVVSR 24 1 Q15393;Q15393-2;I3L4G7 Q15393 SF3B3 Splicing factor 3B subunit 3 1 38808300.0 7484300.0 12773000.0 18551000.0 True False 11354230.275621269 10493558.354095502 14884386.718807856 1.0 0.9241981269858759 1.3109111192474407 23.436726570592413 -6.8558219420856 1.2066071041215027 0.9592462935837736 1.3282022570530823 0.9483623557258998 0.03802126243189423 0.15116933255779844 0.4206011537325843 0.024614661744412084 0.05721619629298588 1.3937281052852565e-07 6.8558219420856 0.3689559634693087 ATGISFAIHGNFSGTK(ub)QQEIVVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATGISFAIHGNFSGTKQQEIVVSR 24 1 Q15393;Q15393-2;I3L4G7 Q15393 SF3B3 Splicing factor 3B subunit 3 1 32432300.0 7484300.0 12330000.0 12618000.0 True False 9688573.887608966 11643824.661058908 10321653.47161326 1.0 1.2018099666815336 1.0653429071551965 23.207852892684862 -10.169637988049704 4.99475265922988 0.9999904879135867 1.1335764369185939 0.5609117791781478 0.055712443757051436 5.9016468121509865e-06 9.811847370261096e-07 0.05394718278514071 0.017981113903851192 6.766467683076077e-11 10.169637988049704 0.1335859490050072 ATGKPHTLWVAFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATGKPHTLWVAFAK 14 1 Q9HCS7 Q9HCS7 XAB2 Pre-mRNA-splicing factor SYF1 0 14270800.0 4056600.0 3847200.0 6367000.0 False True 5318241.884170278 3273212.756268144 5708203.916576622 1.0 0.6154689514989619 1.073325365957322 22.342517964638784 -6.683970942655406 1.8877057390737093 0.757573050611099 1.0716425112505101 0.3423733894726575 0.16283430366287155 0.42978907327853383 2.9643413798500986 0.06912921879533045 0.1814062508034597 2.0702798603895186e-07 6.683970942655406 0.3140694606394111 ATGKPHTLWVAFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATGKPHTLWVAFAK 14 1 Q9HCS7 Q9HCS7 XAB2 Pre-mRNA-splicing factor SYF1 0 11127700.0 3576100.0 1957000.0 5594600.0 False True 3462578.6629581745 2738440.305620179 4129206.425597603 1.0 0.7908673194678141 1.1925234998328993 21.723415416044283 -6.7651871186015216 1.5926984899498575 0.8793128628345164 1.1943927248272241 0.7118879151053819 0.08804066249084158 0.2742801377780696 1.372285774299763 0.04358980784870148 0.1042341688872281 1.7171683745893684e-07 6.7651871186015216 0.31507986199270777 ATGKPHTLWVAFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATGKPHTLWVAFAK 14 1 Q9HCS7 Q9HCS7 XAB2 Pre-mRNA-splicing factor SYF1 0 17019000.0 3974200.0 4715600.0 8329200.0 False True 6029151.95293802 3874064.3368490394 6682929.969181945 1.0 0.6425554318565811 1.1084361484578833 22.52352365945414 -6.701742836881307 1.8249738822752972 0.7784197714790874 1.1070830256756947 0.4257554967205722 0.15083408170478974 0.3918819617074019 2.5387147886985035 0.06591133854994762 0.16912276088918282 1.9872713117900887e-07 6.701742836881307 0.32866325419660736 ATGKPHTLWVAFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATGKPHTLWVAFAK 14 1 Q9HCS7 Q9HCS7 XAB2 Pre-mRNA-splicing factor SYF1 0 12676100.0 4056600.0 4739600.0 3879900.0 False True 5556434.6454929905 4530188.800238729 2963547.52904877 1.0 0.8153049732913383 0.5333541592993634 22.405728026161675 -6.964963766133816 0.3586745234262974 1.0246665607261078 0.314350325150215 0.9999123947061632 0.0017959581389035985 0.07797327729323818 0.014903374272233642 0.003793139116106661 0.024101390038336886 1.0840173515073326e-07 6.964963766133816 -0.7103162355758929 ATGKPHTLWVAFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATGKPHTLWVAFAK 14 1 Q9HCS7 Q9HCS7 XAB2 Pre-mRNA-splicing factor SYF1 0 7835800.0 3576100.0 1772900.0 2486800.0 False True 2973685.5980915474 1763349.0358069031 3006778.3823359264 1.0 0.5929843548149764 1.011128541721296 21.50382069147856 -10.95839815519467 11.291771194172536 1.0671093209403137 0.8020564482685411 0.23005392026124738 0.17070664947190703 0.09581988237758016 0.000353025238064442 0.05491545376109719 0.05509533420763025 1.1005298962648945e-11 10.95839815519467 -0.2650528726717727 ATGKPHTLWVAFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATGKPHTLWVAFAK 14 1 Q9HCS7 Q9HCS7 XAB2 Pre-mRNA-splicing factor SYF1 0 17764400.0 3974200.0 5999200.0 7791000.0 False True 5144680.243193823 5665339.246279364 6373117.942410757 1.0 1.1012033748403216 1.2387782410465842 22.294649981546588 -6.966841257552878 0.32490330649065713 0.9822110273915179 1.3622402542048628 0.9999462203847502 0.0007176073825185664 0.07734160037666124 0.012685833451848653 0.0020455321310316604 0.01205018717723347 1.0793411687538695e-07 6.966841257552878 0.38002922681334494 ATIAGGGVIPHIHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATIAGGGVIPHIHK 14 0 Q71UI9;P0C0S5;Q71UI9-3;Q71UI9-4 Q71UI9 H2AFV;H2AFZ Histone H2A.V;Histone H2A.Z 0 159066000.0 41322000.0 50704000.0 67040000.0 False True 54173542.162817165 43139160.842644036 60103343.89308889 1.0 0.7963141991526125 1.1094593687902088 25.691085089405924 -6.731168841999388 1.719157782422859 0.877582727978656 1.10930707072044 0.5646248647034469 0.0856167342747493 0.3340353874608469 1.9346642293645928 0.039458931703028104 0.09777826361758837 1.8570823311289026e-07 6.731168841999388 0.231724342741784 ATIAGGGVIPHIHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATIAGGGVIPHIHK 14 0 Q71UI9;P0C0S5;Q71UI9-3;Q71UI9-4 Q71UI9 H2AFV;H2AFZ Histone H2A.V;Histone H2A.Z 0 91149300.0 30627000.0 7778300.0 52744000.0 False True 29654762.649372183 10884215.753298638 38928764.113917 1.0 0.367030951553715 1.3127322775837882 24.82176048901131 -6.7263066814321055 1.7364140023252206 0.6175331028477059 1.3118315665572873 0.542201408892496 0.2661709823715126 0.3431987007604651 2.025429197553557 0.12155418590178504 0.3029304288925115 1.8779901867252525e-07 6.7263066814321055 0.6942984637095814 ATIAGGGVIPHIHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATIAGGGVIPHIHK 14 0 Q71UI9;P0C0S5;Q71UI9-3;Q71UI9-4 Q71UI9 H2AFV;H2AFZ Histone H2A.V;Histone H2A.Z 0 108434000.0 22625000.0 70648000.0 15161000.0 False True 34323779.10905905 58040312.424656525 12164421.70469765 1.0 1.6909650956627322 0.35440216725690044 25.032705069081175 -6.766151363023154 1.5889125462157336 1.3982403351281163 0.34788932478010937 0.7158060607312179 0.29094076116704565 0.27265278116881997 1.357817874303195 0.14437553166964415 0.34493945215398086 1.7133600524968116e-07 6.766151363023154 -1.050351010348007 ATIAGGGVIPHIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATIAGGGVIPHIHK 14 0 Q71UI9;P0C0S5;Q71UI9-3;Q71UI9-4 Q71UI9 H2AFV;H2AFZ Histone H2A.V;Histone H2A.Z 0 134098000.0 41322000.0 41347000.0 51429000.0 False True 56599860.085061684 39520152.82375528 39282529.413502686 1.0 0.6982376416542728 0.6940393378087248 25.754295150928815 ATIAGGGVIPHIHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATIAGGGVIPHIHK 14 0 Q71UI9;P0C0S5;Q71UI9-3;Q71UI9-4 Q71UI9 H2AFV;H2AFZ Histone H2A.V;Histone H2A.Z 0 64953000.0 30627000.0 18706000.0 15620000.0 False True 25467707.50615187 18605227.065149724 18886069.781280022 1.0 0.7305418856666045 0.7415692903147244 24.602165764445587 -9.98117808383625 5.5953240891125 1.0000005258642497 0.736055587993932 0.9986925789316506 0.004501919096733537 2.953491341417605e-08 5.380586975361714e-09 0.004358973092636303 0.001452988140506525 1.0442919161852624e-10 9.98117808383625 -0.2639449378703177 ATIAGGGVIPHIHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATIAGGGVIPHIHK 14 0 Q71UI9;P0C0S5;Q71UI9-3;Q71UI9-4 Q71UI9 H2AFV;H2AFZ Histone H2A.V;Histone H2A.Z 0 80070000.0 22625000.0 30683000.0 26762000.0 False True 29288508.505425006 28975464.077475306 21891590.601308793 1.0 0.9893116978663589 0.7474464122081836 24.803831391173624 -6.916156729879855 0.8527381125188588 1.0061108785809485 0.7116936947351892 0.9930451658556785 0.009725374381087478 0.10048630845192143 0.11772007003185811 0.00821313231892162 0.023766887907204787 1.2129510369872945e-07 6.916156729879855 -0.2944171838457593 ATIAGGGVIPHIHKSLIGK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATIAGGGVIPHIHKSLIGK 19 1 Q71UI9;P0C0S5;Q71UI9-3;Q71UI9-4 Q71UI9 H2AFV;H2AFZ Histone H2A.V;Histone H2A.Z 1 49302000.0 17480000.0 15382000.0 16440000.0 True False 26518437.95917582 12636961.919885453 13190626.794092039 1.0 0.4765349278618748 0.49741341531497946 24.660492461723845 -10.123793422243416 4.905340311839315 1.0000258254431762 0.486974171586112 0.9987593709797111 0.008523606818202401 2.407482263628261e-06 4.300244476047498e-07 0.008253361518731081 0.002750982270235219 7.519804981585227e-11 10.123793422243416 -0.5130516538570642 ATIEDILFK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATIEDILFKAK 11 1 Q6P1K8;Q13888;D6RJD3;D6RID8;D6RIT7;D6RGC9;R4GMS9;D6RAW1 Q6P1K8 GTF2H2C;GTF2H2 General transcription factor IIH subunit 2-like protein;General transcription factor IIH subunit 2 1 25704100.0 787400.0 6008100.0 18908600.0 True False 1194543.3666507474 4935907.613500446 15171306.922066227 1.0 4.1320455592497325 12.700507445454605 20.188027799607564 -6.953503419746979 0.5189610625230663 0.8532216632828942 16.36103304287445 0.9994483022361135 0.11616334108210324 0.08210874245811361 0.030371004443596385 0.13181690889766773 0.7076880644728364 1.1130036286890962e-07 6.953503419746979 15.507811379591555 ATIELCSTHANDASALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATIELCSTHANDASALR 17 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 14882900.0 3414500.0 5513300.0 5955100.0 False True 4476442.566065038 4690737.130675082 5338923.377352831 1.0 1.0478716215940234 1.1926710325350933 22.09392124556342 -6.951266553380998 0.5447699515789677 0.9979325332991226 1.2493517500230935 0.999296907970714 0.0021718625111572113 0.08298127736001605 0.03388932542648571 0.002373455637901068 0.01200094513613152 1.1187510260152763e-07 6.951266553380998 0.25141921672397094 ATIELCSTHANDASALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATIELCSTHANDASALR 17 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 8423300.0 3414500.0 1738300.0 3270500.0 False True 4676932.923392948 1661496.1582106033 2498075.258061804 1.0 0.3552533648494679 0.534126808953578 22.15713130708631 -10.849223215400801 10.994617696253512 1.0122124366020187 0.4446900869021569 0.9278001045212754 0.0730247777648863 0.020391992398443397 0.000279648968799121 0.06595696620761463 0.023568645678658524 1.4150662879245033e-11 10.849223215400801 -0.5675223496998618 ATIGADFLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATIGADFLTK 10 0 P51149;C9J8S3;C9J4V0;C9J4S4;C9J592;C9IZZ0;C9J7D1 P51149 RAB7A Ras-related protein Rab-7a 0 17277700.0 4728600.0 5264800.0 7284300.0 False True 6199240.391827542 4479312.362029662 6530590.511939543 1.0 0.7225582618049042 1.0534501163318042 22.563660018681542 -6.684277896093794 1.8867384318279077 0.8251451606954603 1.0522372252267556 0.3439336461286985 0.1174765449954263 0.4290036082365338 2.9561794072167826 0.04989595400426786 0.13087799571005673 2.0688171316955183e-07 6.684277896093794 0.22709206453129527 ATIGADFLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATIGADFLTK 10 0 P51149;C9J8S3;C9J4V0;C9J4S4;C9J592;C9IZZ0;C9J7D1 P51149 RAB7A Ras-related protein Rab-7a 0 13039500.0 4728600.0 3782100.0 4528800.0 False True 6476891.205610163 3614994.316267805 3459190.713563769 1.0 0.5581372608415229 0.5340819544054535 22.626870080204434 -13.999999999999998 0.41472023360952365 9.190683509691958 0.5331412794942294 0.9998575433258555 0.0025564775683273445 29.07218996042549 0.21409228903265168 215.40886515682868 0.005917169380037943 1.0000000000000041e-14 13.999999999999998 -8.657542230197729 ATIGILITTIASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATIGILITTIASK 13 0 O14787-2;O14787;A0A075B780 O14787-2 TNPO2 Transportin-2 0 7425800.0 0.0 2977600.0 4448200.0 False True 0.0 2446224.0159050175 3569011.3202846763 0.0 ATIGVGLGLPSFK(ub)PGFAEQSLMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ATIGVGLGLPSFKPGFAEQSLMK 23 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 149127600.0 61941100.0 30995500.0 56191000.0 True False 59974813.68534399 43372164.78939715 41472891.40613358 1.0 0.7231729808607306 0.6915051311992368 25.83785343493537 -13.999999999999753 0.3060124246660642 3.614410743988772 0.6841881279534004 0.9996631967173031 0.002542986803355215 16.99072394058508 0.17587135360797146 28.221663309034632 0.011156589873714168 1.0000000000005686e-14 13.999999999999753 -2.9302226160353713 ATIGVGLGLPSFK(ub)PGFAEQSLMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 ATIGVGLGLPSFKPGFAEQSLMK 23 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 489786400.0 104717000.0 231518400.0 153551000.0 True False 158863344.83815855 190202132.65848443 123201577.54620574 1.0 1.1972688404128224 0.7755192217041439 27.24321104350463 -6.779477998452033 1.5376167786529311 1.1117702652692494 0.7722146789780384 0.7656678639210546 0.0834057745150673 0.25136723797005217 1.1737761209079651 0.0427226845008506 0.1008637740481978 1.6615828521468397e-07 6.779477998452033 -0.33955558629121096 ATIGVGLGLPSFK(ub)PGFAEQSLMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ATIGVGLGLPSFKPGFAEQSLMK 23 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 150166300.0 61941100.0 48017300.0 40207900.0 True False 51506769.10599491 47758621.274212144 48615185.98967541 1.0 0.9272299952639329 0.9438601339880403 25.618258710369645 -10.118734196014392 5.053642245111353 1.0000022680576068 0.9355450646258381 0.9524465969813247 0.00678922570480996 1.7350210018770134e-07 3.0259028169055013e-08 0.006573870894608703 0.002191213173957042 7.607917666514184e-11 10.118734196014392 -0.06445720343176875 ATIGVGLGLPSFK(ub)PGFAEQSLMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ATIGVGLGLPSFKPGFAEQSLMK 23 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 410153500.0 104717000.0 242925500.0 62511000.0 True False 135558220.78066698 229406482.37632337 51134639.41702461 1.0 1.6923096294359214 0.37721533317968514 27.01433736559708 -6.763629251714806 1.5985419674802226 1.400294864268621 0.37147381469641866 0.7057647565667378 0.2913605998952459 0.27683057900702124 1.3949201262631563 0.1437494080651655 0.34426298632536095 1.7233391264471647e-07 6.763629251714806 -1.0288210495722023 ATIGVGLGLPSFKPGFAEQSLMKNAIK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATIGVGLGLPSFKPGFAEQSLMKNAIK 27 2 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 31954000.0 10271000.0 12739000.0 8944000.0 True False 13296011.971678257 12030063.451519025 7316283.773189801 1.0 0.9047873510601661 0.550261521182003 23.664490250430106 -6.9465217725888495 0.595807805052936 1.0040329079395156 0.43299786028535003 0.9988992859968079 0.0064201152278912646 0.08491322591636945 0.0419796690990392 0.006616767570015636 0.029753463971810792 1.1310406851798893e-07 6.9465217725888495 -0.5710350476541656 ATIK(ub)DASLQPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATIKDASLQPR 11 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 23322900.0 5807700.0 12776000.0 4739200.0 True False 7613950.9418468 10869870.600457948 4248833.045616447 1.0 1.4276255105238975 0.5580326269590952 22.860213843692126 -6.773019265852326 1.5631231713774576 1.2443340857217298 0.5526018244940807 0.7418692371567415 0.18037648586234917 0.26158953385702927 1.2618285637878566 0.09093864162190118 0.21585767835252131 1.6864782094235875e-07 6.773019265852326 -0.6917322612276491 ATIK(ub)DASLQPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATIKDASLQPR 11 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 47393000.0 15661000.0 15395000.0 16337000.0 True False 15163850.127397973 21542303.78386444 12057849.600505512 1.0 1.420635498430699 0.795170718465454 23.85413276696118 -6.725505244063884 1.7394768348989607 1.254391706771043 0.7958275249043165 0.538383614403378 0.17689609488032848 0.3447235306625641 2.0412485233703697 0.08065756745475178 0.2011836626354891 1.8814589876458098e-07 6.725505244063884 -0.45856418186672654 ATIK(ub)DASLQPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATIKDASLQPR 11 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 13399900.0 8185000.0 5214900.0 0.0 True False 12417243.403652983 4284260.35080033 0.0 1.0 0.34502507614048694 0.0 23.5658415986974 -8.521456696495417 0.510455883460393 1.0528495508145381 2.7652678644786874e-22 0.9936126042583245 0.033145987492514586 0.23122645717771237 0.18478861572038527 0.08209430485815096 0.06627024559410234 3.009839264997198e-09 8.521456696495417 -1.0528495508145381 ATIK(ub)DASLQPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATIKDASLQPR 11 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 18169400.0 5807700.0 7733400.0 4628300.0 True False 7954963.637191156 7391712.817066037 3535190.8628305914 1.0 0.9291950477948383 0.444400631362137 22.923423905215017 -6.933109318816426 0.7208111149745197 1.0065893938892205 0.33650643173389266 0.9971148621449921 0.013262982389135092 0.09105515453213447 0.07000408643038096 0.012314987802011044 0.04314009844050938 1.1665159495167545e-07 6.933109318816426 -0.6700829621553279 down ATIK(ub)DASLQPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATIKDASLQPR 11 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 52862000.0 15661000.0 32385000.0 4816000.0 True False 13022815.399936147 32210535.57708081 5823003.333331927 1.0 2.4733926257788115 0.4471385913494925 23.634538042395455 -6.7117024610175715 1.7889697819696286 1.9042426189809323 0.45163178478667837 0.47318286220177497 0.6207200579945951 0.3717049713865319 2.319941086036769 0.27599625799819216 0.699760191898592 1.9422160512416767e-07 6.7117024610175715 -1.4526108341942539 ATILCTSYVQFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATILCTSYVQFK 12 0 P35244;B5MC59 P35244 RPA3 Replication protein A 14 kDa subunit 0 34744900.0 9936900.0 13588000.0 11220000.0 False True 15075003.784698743 11163115.236471439 9002362.082099313 1.0 0.7405049707385212 0.5971714641449567 23.845655028536925 -13.999999999995703 0.07105753964011063 2.4891355379814595 0.08812177184492558 0.9999207823033097 0.001483848000555093 12.34934159011156 0.0722985592429686 3.0290715725335025 0.46810397758038325 1.0000000000098942e-14 13.999999999995703 -2.401013766136534 ATILCTSYVQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATILCTSYVQFK 12 0 P35244;B5MC59 P35244 RPA3 Replication protein A 14 kDa subunit 0 34010800.0 8612800.0 10492000.0 14906000.0 False True 11797184.912168322 10028428.747595726 11385509.798706386 1.0 0.8500696413812929 0.9651039534832323 23.491939303647918 -10.198928495590332 5.108480909194091 1.0000074726490087 0.9075867975321606 0.46251070624981516 0.04696256126052377 3.997198975847349e-06 6.268127033031433e-07 0.04547498086381338 0.015157101471406188 6.325159833899363e-11 10.198928495590332 -0.09242067511684804 ATILCTSYVQFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATILCTSYVQFK 12 0 P35244;B5MC59 P35244 RPA3 Replication protein A 14 kDa subunit 0 54903900.0 9936900.0 26337000.0 18630000.0 False True 12863512.93558267 24871322.797916356 15239531.159942543 1.0 1.9334782747501298 1.1847099028281305 23.616781350629374 -10.22864854368719 4.7488979261516056 0.9998785545148954 1.559094088790732 0.42640309816099453 0.3056834077965212 0.00039316543001834147 6.386133061491452e-05 0.29604044723433665 0.09865889563314334 5.906788984700375e-11 10.22864854368719 0.5592155342758367 ATILDLSCNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATILDLSCNK 10 0 Q96AG4 Q96AG4 LRRC59 Leucine-rich repeat-containing protein 59 0 3315070.0 676470.0 0.0 2638600.0 False True 886858.7209447984 0.0 2365582.983238433 1.0 0.0 2.6673729731363562 19.758344771943747 -6.8051526606180275 1.434740822131667 0.4518095367791031 2.7090710864662704 0.846815629317806 0.4306255702047903 0.2134819058840693 0.8669547830238654 0.23606195669595378 0.547373388156191 1.5662004318574403e-07 6.8051526606180275 2.257261549687167 ATIQFHQPQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATIQFHQPQR 10 0 Q8IUF8-4;Q8IUF8;Q8IUF8-2 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 0 3919930.0 732730.0 1420200.0 1767000.0 False True 960616.1257674138 1208311.695896241 1584167.7902608619 1.0 1.2578507308847737 1.6491163824626691 19.873600501593657 -6.965064933904428 0.3569400260529826 0.9650838720558889 1.9552278855574947 0.999914472776951 0.002467938465343862 0.07793898073585241 0.014782550199108522 0.005283347468941475 0.03348123420762533 1.0837648618927395e-07 6.965064933904428 0.9901440135016059 ATIQFHQPQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATIQFHQPQR 10 0 Q8IUF8-4;Q8IUF8;Q8IUF8-2 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 0 3324530.0 732730.0 1333700.0 1258100.0 False True 1003640.082283706 1274772.724043884 960962.6913828322 1.0 1.27014927616605 0.9574773948806781 19.93681056311655 -6.678198207848862 1.9089371282068601 1.1712057933296474 0.9587009317602692 0.31569988257512005 0.11454145386160118 0.4424853839667968 3.1160824264325147 0.04818203241525739 0.12734076357003868 2.0979821660936696e-07 6.678198207848862 -0.2125048615693782 ATIQGVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATIQGVLR 8 0 O95782;O95782-2 O95782 AP2A1 AP-2 complex subunit alpha-1 0 9468600.0 1836900.0 2776200.0 4855500.0 False True 2408193.688564907 2362001.781542841 4353099.437244824 1.0 0.98081885720347 1.807620150287383 21.19952000058063 -6.901591594318862 0.9511674754795976 0.9671088860069529 1.8972622047388228 0.9873409585671481 0.04335287552328288 0.11024325864585093 0.17089394538986089 0.03407957626725305 0.08939704771877233 1.2543201691784785e-07 6.901591594318862 0.9301533187318699 ATIQGVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATIQGVLR 8 0 O95782;O95782-2 O95782 AP2A1 AP-2 complex subunit alpha-1 0 6341800.0 1836900.0 1657100.0 2847800.0 False True 2516051.570355986 1583883.842703097 2175208.2922820384 1.0 0.6295116766938922 0.8645324753714317 21.262730062103522 -10.359022181620487 6.262994165818783 1.0000244704686754 0.7470220760326619 0.6070523165636637 0.09594683928355742 3.278667589216603e-05 3.355466537425412e-06 0.0929091009080647 0.030966709222204757 4.374997592573497e-11 10.359022181620487 -0.25300239443601347 ATISNDGATILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATISNDGATILK 12 0 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 0 29007900.0 1508900.0 11100000.0 16399000.0 False True 1978182.5122083868 9443923.267461127 14702188.79031569 1.0 4.774040417998741 7.432170034655995 20.91574410831845 -8.094412978902986 0.3030143709875926 1.0333772877373725e-22 9.04409591601409 0.9989650848918392 0.08489888666047207 0.09627083280717148 0.0665375696549476 0.5653499882564844 0.7730774947421156 8.046129554993536e-09 8.094412978902986 9.04409591601409 ATISNDGATILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATISNDGATILK 12 0 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 0 22959800.0 8051100.0 2146700.0 12762000.0 False True 7795522.237449337 3003888.504892609 9419249.348206613 1.0 0.3853351210342348 1.2082897157238504 22.894214244478267 -6.706771879978871 1.806821588596586 0.6208790371694146 1.2061713074745783 0.44974267567286663 0.2591505652979836 0.38158284927277347 2.4262702172751127 0.11423068133151365 0.29132936132396836 1.9643918336611634e-07 6.706771879978871 0.5852922703051637 ATISNDGATILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATISNDGATILK 12 0 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 0 28263000.0 1508900.0 9221100.0 17533000.0 False True 2066781.1064892726 8813681.311900025 13392066.503469668 1.0 4.264448365734938 6.47967337296693 20.97895416984134 -8.171593638266923 0.29019720452453757 2.5510034585614313e-24 7.906652945518758 0.9990735375814733 0.06850631575135327 0.09359363187523716 0.06619228504611686 0.5587096258198829 0.6829781539951066 6.736066434316142e-09 8.171593638266923 7.906652945518758 ATISNDGATILK(ub)LLDVVHPAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATISNDGATILKLLDVVHPAAK 22 1 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 1 12315200.0 2133600.0 3233500.0 6948100.0 True False 1774182.9345063397 3216080.493700504 8400915.58561535 1.0 1.8127107589361224 4.735089838947682 20.75872334170183 -6.947323876944185 0.5874895495386762 0.9659604436664275 5.728257431259581 0.9989741907146729 0.05136927611379598 0.0845784744281732 0.04054928741014985 0.05339517911106344 0.2446406398195513 1.1289536786871305e-07 6.947323876944185 4.762296987593153 ATK(ub)HYEMLANR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATKHYEMLANR 11 1 A0A2R8YFH5;Q15437 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 8631300.0 2708100.0 2366900.0 3556300.0 True False 3550345.325277708 2013767.7461039377 3188328.1904384294 1.0 0.5672033454791953 0.8980332610853955 21.759527924881247 -10.374330193136187 6.042355778530897 1.0000443210391456 0.7326183032822994 0.46551177979698966 0.13506074748053581 8.06532477395722e-05 8.351300955598728e-06 0.13079363388057377 0.043590668809869976 4.2234738238234525e-11 10.374330193136187 -0.26742601775684627 ATK(ub)HYEMLANR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATKHYEMLANR 11 1 A0A2R8YFH5;Q15437 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 10080500.0 2708100.0 3078800.0 4293600.0 True False 3709357.7536507393 2942768.4357698937 3279540.1094677113 1.0 0.7933363755150414 0.8841261283681784 21.82273798640414 -10.158680404649814 4.601096211436955 1.0000200045150995 0.8387312519415951 0.807948325383972 0.03706476141462287 8.253434059245028e-06 1.5091439435309157e-06 0.03589262904859375 0.011962600304455813 6.939362827449851e-11 10.158680404649814 -0.1612887525735044 ATK(ub)KGEQELAEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATKKGEQELAEVK 13 2 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 15753200.0 2869900.0 6859800.0 6023500.0 True False 4353848.117793973 5635615.094137969 4832952.584806164 1.0 1.2943986426870233 1.1100416123966552 22.05385964990327 -10.30802201559936 4.572050755878321 0.999861305776254 1.2022201275424107 0.6160101300031555 0.07526344245335295 0.00010647790342803712 1.6115373732823115e-05 0.0729233400690623 0.02429117159968017 4.920145934563558e-11 10.30802201559936 0.20235882176615672 ATK(ub)KGEQELAEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATKKGEQELAEVK 13 2 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 19903000.0 2869900.0 10785000.0 6248100.0 True False 3715142.124186487 10184805.269223064 5111009.910919855 1.0 2.7414308601863393 1.375723926588414 21.82498597199572 -6.585134369877665 2.247521035080176 2.18217764507003 1.379425197332437 0.0 0.755549057237725 0.6838691771077728 6.505177890389438 0.2814396913056912 0.8431741866665585 2.5993552032359844e-07 6.585134369877665 -0.8027524477375931 ATK(ub)VQDIK(ub)NNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATKVQDIKNNLK 12 2 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;A0A590UJQ9;S4R3E3;A0A590UJ22;Q5JWE9;A0A590UJY8;S4R3V9;A0A590UJB7;A0A590UJC9;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;A0A590UK28;A0A590UKA1;A0A590UJA5;A0A590UKA9;P63092-3;A0A590UJF0;A0A590UJG5;H0Y7F4;A0A590UKA4 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 2 7416390.0 583290.0 1592600.0 5240500.0 True False 485031.479128329 1584020.3476936503 6336264.320665677 1.0 3.2658093667247363 13.063614617452975 18.887718857424336 -6.94308825664487 0.6301775499822676 0.8931216544654839 15.964512080042159 0.9985410764832386 0.19996125225340078 0.08638555574032458 0.04840276562069131 0.1995464977785953 0.8324869671520218 1.1400180913272891e-07 6.94308825664487 15.071390425576675 ATLELTHNWGTEDDETQSYHNGNSDPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATLELTHNWGTEDDETQSYHNGNSDPR 27 0 Q04760 Q04760 GLO1 Lactoylglutathione lyase 0 66786000.0 19516000.0 21765000.0 25505000.0 False True 25585664.99321286 18517746.8393055 22865987.261235554 1.0 0.7237547604964626 0.8937030664358828 24.608832394918988 -10.360492384846404 5.538825629388025 1.0000548941162988 0.808728913839944 0.6281005855713054 0.06938110536700445 4.704496503202888e-05 5.431779036336425e-06 0.06719721364073247 0.02239265546898824 4.3602120936433574e-11 10.360492384846404 -0.19132598027635472 ATLELTHNWGTEDDETQSYHNGNSDPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATLELTHNWGTEDDETQSYHNGNSDPR 27 0 Q04760 Q04760 GLO1 Lactoylglutathione lyase 0 52937000.0 14795000.0 11628000.0 26514000.0 False True 14325340.823373549 16271121.039218942 19569187.997049835 1.0 1.1358278479958128 1.3660539206941804 23.772066127685274 -6.963147267708227 0.3885440459156776 0.9856289499858548 1.5245057605038796 0.9998697052102568 0.0017246126146538 0.07859547039588448 0.017112932685143828 0.002975057228142509 0.019378282868843816 1.088560903625646e-07 6.963147267708227 0.5388768105180248 ATLELTHNWGTEDDETQSYHNGNSDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATLELTHNWGTEDDETQSYHNGNSDPR 27 0 Q04760 Q04760 GLO1 Lactoylglutathione lyase 0 88179000.0 19516000.0 34028000.0 34635000.0 False True 26731592.600069355 32524530.444451716 26454926.330215733 1.0 1.2167075464245751 0.9896502137379984 24.67204245644188 -6.6567713379382285 1.984744242517721 1.1398625473825839 0.9906080268772891 0.2218772635314178 0.09234104585909125 0.49209841613939004 3.7230803940628365 0.03763733746661395 0.10230688459666576 2.2040866397550415e-07 6.6567713379382285 -0.14925452050529475 ATLEVILRPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATLEVILRPK 10 1 Q9NQT4;M0R102 Q9NQT4 EXOSC5 Exosome complex component RRP46 0 16419700.0 4091000.0 4995300.0 7333400.0 False True 5363340.617300351 4250020.711526897 6574610.114940016 1.0 0.7924204362142775 1.225842359094724 22.354700448881005 -6.776452285889437 1.5494975496944412 0.8819223315708287 1.2289131481684286 0.7547042563626902 0.08766146604127743 0.25612508782771837 1.214323462347812 0.04456891640262305 0.10548862541435908 1.6731994536968923e-07 6.776452285889437 0.3469908165975999 ATLEVILRPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATLEVILRPK 10 1 Q9NQT4;M0R102 Q9NQT4 EXOSC5 Exosome complex component RRP46 0 11156300.0 4180200.0 2128600.0 4847500.0 False True 4047501.8391257953 2978561.080502358 3577794.328117183 1.0 0.7359011061365412 0.883951254458216 21.948600305391746 -10.136038443069172 4.946072302325282 1.0000101322448205 0.8099261804869275 0.6872738609281897 0.060441219957357926 6.753451919129032e-06 1.1796438925550711e-06 0.058525078225247266 0.01950731985964045 7.310743670581247e-11 10.136038443069172 -0.19008395175789294 ATLEVILRPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATLEVILRPK 10 1 Q9NQT4;M0R102 Q9NQT4 EXOSC5 Exosome complex component RRP46 0 47431200.0 10875100.0 20905100.0 15651000.0 False True 16498321.776306234 17174421.572708186 12557572.989923004 1.0 1.0409799133250583 0.7611424458915169 23.975815943947 -6.869685005149016 1.1356855356323177 1.0231358472037504 0.7448463094778156 0.9643717031377723 0.023291742854756787 0.13716116474216847 0.33082691142628556 0.015918886572906486 0.03767026277676329 1.3499416435789528e-07 6.869685005149016 -0.2782895377259348 ATLEVILRPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATLEVILRPK 10 1 Q9NQT4;M0R102 Q9NQT4 EXOSC5 Exosome complex component RRP46 0 21791600.0 4091000.0 7121100.0 10579500.0 False True 5603553.255118035 6806466.255671374 8080839.991641899 1.0 1.2146696829292472 1.4420921197208612 22.417910510403896 -6.970394349895705 0.24859112069384784 0.9265642996376231 1.736846460134011 0.9999852949633455 0.0006921740592285246 0.07617498468787384 0.00857126870275416 0.0051211779261227715 0.021846810415883895 1.0705467813914439e-07 6.970394349895705 0.8102821604963879 ATLEVILRPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATLEVILRPK 10 1 Q9NQT4;M0R102 Q9NQT4 EXOSC5 Exosome complex component RRP46 0 7671750.0 4180200.0 626500.0 2865050.0 False True 3476021.5142591884 623124.9201494871 3464118.7085055257 1.0 0.1792638272212443 0.9965757387562661 21.729005580826023 -9.106228429655182 12.532924144319162 1.0000097351474826 0.5879197829901649 0.25314219184340414 0.33366619070726633 0.0 0.0 0.32307089992903637 0.10769029997634544 7.830176837967466e-10 9.106228429655182 -0.4120899521573177 ATLEVILRPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATLEVILRPK 10 1 Q9NQT4;M0R102 Q9NQT4 EXOSC5 Exosome complex component RRP46 0 45745200.0 10875100.0 25588400.0 9281700.0 False True 14078031.33026952 24164383.045988616 7592525.838284418 1.0 1.7164603827832223 0.5393172994266281 23.74694226603945 -6.741956632409746 1.6794492430345225 1.4253203151605869 0.5383173005737643 0.6137290451435709 0.30101662042914035 0.31428779770308024 1.741294067258582 0.14174794720041628 0.3471036669884054 1.8115209776651877e-07 6.741956632409746 -0.8870030145868226 ATLNAFLYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATLNAFLYR 9 0 Q9NVI7-2;Q9NVI7-3;Q9NVI7;Q5T2N8;Q5SV16 Q9NVI7-2 ATAD3A;ATAD3C ATPase family AAA domain-containing protein 3A;ATPase family AAA domain-containing protein 3C 0 20631400.0 7155500.0 6155700.0 7320200.0 False True 9380929.793960579 5237293.554730663 6562775.924316676 1.0 0.5582915201116228 0.6995869352462031 23.161299492348054 -10.906969270409064 11.192540864820383 1.03374386318502 0.628939227678913 0.9019169692559939 0.05768361167907425 0.03018148090542074 0.0002508635157431053 0.03470568403868414 0.018617305615179176 1.2388842437785335e-11 10.906969270409064 -0.404804635506107 ATLNAFLYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATLNAFLYR 9 0 Q9NVI7-2;Q9NVI7-3;Q9NVI7;Q5T2N8;Q5SV16 Q9NVI7-2 ATAD3A;ATAD3C ATPase family AAA domain-containing protein 3A;ATPase family AAA domain-containing protein 3C 0 19747800.0 4652000.0 6128900.0 8966900.0 False True 7057424.106755485 5035149.9096857365 7194588.284668117 1.0 0.7134543472973385 1.0194354449779115 22.750710278809102 -11.044134404416571 12.437785055285369 1.472709929637792 0.866444896137625 0.2025655217696356 0.12491626004235022 0.04167533898474283 0.00014788152657149888 0.0030784085579804808 0.04031654956787811 9.033698577161623e-12 11.044134404416571 -0.6062650335001669 ATLNAFLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATLNAFLYR 9 0 Q9NVI7-2;Q9NVI7-3;Q9NVI7;Q5T2N8;Q5SV16 Q9NVI7-2 ATAD3A;ATAD3C ATPase family AAA domain-containing protein 3A;ATPase family AAA domain-containing protein 3C 0 18064900.0 7155500.0 6301300.0 4608100.0 False True 9801081.72011664 6022887.730387437 3519761.6867985316 1.0 0.6145125509999074 0.35911971630378814 23.224509553870945 -8.311377161222653 0.182296016088086 1.3230303239985224 1.6639987486399857e-09 0.9998314705277563 0.0034198016603389876 0.09555021366786273 0.04042590848717346 0.12554132047364205 0.12419047754423146 4.8822817546635e-09 8.311377161222653 -1.3230303223345237 down ATLNAFLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATLNAFLYR 9 0 Q9NVI7-2;Q9NVI7-3;Q9NVI7;Q5T2N8;Q5SV16 Q9NVI7-2 ATAD3A;ATAD3C ATPase family AAA domain-containing protein 3A;ATPase family AAA domain-containing protein 3C 0 9721900.0 4229600.0 2253600.0 3238700.0 False True 3517099.8030502535 2241459.409495421 3915897.195943124 1.0 0.637303328029385 1.1133881365968086 21.745954843531848 -6.703049265369348 1.8198586770005731 0.7754574525891808 1.112062114590335 0.432111157016715 0.1530149768186502 0.38921963954846084 2.508126085244678 0.06702267484728348 0.17172756288442667 1.9813022586755487e-07 6.703049265369348 0.33660466200115435 ATLNAFLYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATLNAFLYR 9 0 Q9NVI7-2;Q9NVI7-3;Q9NVI7;Q5T2N8;Q5SV16 Q9NVI7-2 ATAD3A;ATAD3C ATPase family AAA domain-containing protein 3A;ATPase family AAA domain-containing protein 3C 0 34639000.0 4652000.0 13962000.0 16025000.0 False True 6022105.70462927 13185002.426415617 13108614.43038537 1.0 2.1894339078572025 2.1767493088519867 22.52183660090155 -10.445371665122211 6.3992798509428965 0.9996659615613872 2.183091608354595 0.9999137932842876 0.005178465859099145 2.4685526042698535e-05 2.1395130188490985e-06 0.00501532133739554 0.001671342669266214 3.586149040336631e-11 10.445371665122211 1.1834256467932076 ATLVCLISDFYPGAVTVAWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATLVCLISDFYPGAVTVAWK 20 0 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-1 chain C regions 0 8832800000.0 3968700000.0 3112700000.0 1751400000.0 False True 6020808050.834172 2557214365.3638964 1405235022.3341095 1.0 0.4247294289691894 0.233396416306515 32.48730997763218 -13.99999999999987 0.15381688347619982 3.7992949636049276 0.0318574608653814 0.9995540036103874 0.006880139466826708 11.97413887718895 0.12370108302142577 10.008828523755321 0.18236533767826452 1.0000000000002987e-14 13.99999999999987 -3.767437502739546 ATLVCLISDFYPGAVTVAWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATLVCLISDFYPGAVTVAWK 20 0 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-1 chain C regions 0 5988160000.0 3968700000.0 373960000.0 1645500000.0 False True 5137560384.7726 353148797.26274025 1346035884.255795 1.0 0.06873861732301009 0.2619990391247486 32.25843629972462 -10.225853289516259 7.662059421593598 1.0000009770943548 0.1653688282239195 0.9613423041792333 0.07889823681488482 1.3169195858474307e-06 1.3296936369966237e-07 0.07639297921346198 0.025464296435764828 5.944929523676298e-11 10.225853289516259 -0.8346321488704352 ATLVESSTSGFTPGGGGSSVSMIASR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATLVESSTSGFTPGGGGSSVSMIASR 26 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YDS9 P49321 NASP Nuclear autoantigenic sperm protein 0 45569300.0 6631500.0 29221000.0 9716800.0 False True 10060470.327590067 24006284.245284963 7796270.220975263 1.0 2.3861990009999405 0.7749409289140877 23.262194417011106 -6.679025737744377 1.9052680249286937 1.8778218612582147 0.7811050255409253 0.3197196259982239 0.5876280089264044 0.4406826941843183 3.0919897428635585 0.24755399127712563 0.6537424605627229 2.0939883554160895e-07 6.679025737744377 -1.0967168357172894 ATLVESSTSGFTPGGGGSSVSMIASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATLVESSTSGFTPGGGGSSVSMIASR 26 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YDS9 P49321 NASP Nuclear autoantigenic sperm protein 0 21861700.0 6631500.0 10099000.0 5131200.0 False True 8584607.476407781 9536981.77226553 4197374.250558087 1.0 1.1109397603181115 0.4889418953741695 23.033320739103555 -6.8607986224933475 1.1817733708859413 1.0603177770994388 0.45837029809433694 0.9545996516124532 0.057716740066061 0.1459762723637462 0.38694858903805374 0.03808126845855728 0.0889696848542779 1.377848213639701e-07 6.8607986224933475 -0.6019474790051018 down ATLWYVPLSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATLWYVPLSLK 11 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 141587000.0 33827000.0 45599000.0 62161000.0 False True 44347524.58113402 38795806.94350991 55729176.01041622 1.0 0.8748133590305087 1.2566468261032113 25.402350241698596 -6.818380877902928 1.3787324041809415 0.9324089267865734 1.264704403356328 0.8806248740120184 0.05491232762285784 0.19561073705983165 0.7310531066779667 0.031300045686489746 0.07217923527053008 1.5192145883816583e-07 6.818380877902928 0.33229547656975456 ATLWYVPLSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATLWYVPLSLK 11 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 123205000.0 45610000.0 21981000.0 55614000.0 False True 44162135.51565171 30758127.929400705 41047025.01576255 1.0 0.6964818972239142 0.9294619595833377 25.396306601349107 -9.810700935637536 5.592781470368587 1.000000041726998 0.8129719293396483 0.4621460096423984 0.09511371217610019 4.951676956043634e-08 1.0550904238919831e-08 0.09209347639548256 0.030697818603671663 1.5463189008797997e-10 9.810700935637536 -0.18702811238734973 ATLWYVPLSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATLWYVPLSLK 11 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 47590600.0 8445600.0 19617000.0 19528000.0 False True 12812592.65606494 16116193.081679445 15668282.240573537 1.0 1.2578401198176483 1.222881477712228 23.61105910191934 -10.090357185689408 4.544929042574675 0.9999823558154562 1.240360798774039 0.9843826579130188 0.014271805907471005 2.5517740844488066e-06 5.107210633131681e-07 0.013819630555018642 0.004606205551782329 8.121622781792774e-11 10.090357185689408 0.2403784429585828 ATLWYVPLSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATLWYVPLSLK 11 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 161580000.0 33827000.0 42163000.0 85590000.0 False True 46333756.04030264 40300099.24560414 65375404.78138195 1.0 0.8697783795155691 1.4109670868149833 25.465560303221487 -6.84316752375095 1.2676159857666234 0.9307292355971469 1.4299119577997266 0.929766622029273 0.06112219520264953 0.1651274219649167 0.5140430801162161 0.03778853146470576 0.08714507988654215 1.4349358177552967e-07 6.84316752375095 0.49918272220257964 ATLWYVPLSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATLWYVPLSLK 11 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 91654000.0 45610000.0 18206000.0 27838000.0 False True 37926735.86559527 18107920.664391942 33658797.09163084 1.0 0.4774447431638402 0.887468861304354 25.176711876783383 -9.887363398249708 6.59914522671049 1.0000000144328565 0.6824568022340871 0.44435096177974964 0.16739164527986322 3.566251157257988e-08 5.855606231779213e-09 0.16207627086113804 0.054025421205257405 1.296094303223412e-10 9.887363398249708 -0.31754321219876935 ATLWYVPLSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATLWYVPLSLK 11 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 68763600.0 8445600.0 30594000.0 29724000.0 False True 10932995.687664865 28891417.005712587 24314536.993995294 1.0 2.6425892619997358 2.223959259531048 23.38218542401179 -10.285498622400013 5.4561763764565905 0.9998189144634172 2.4332742607654483 0.9398648018461697 0.17090498284492286 0.0003765138488236171 4.930566074355607e-05 0.16549807478109105 0.055159346028492096 5.182047357713891e-11 10.285498622400013 1.433455346302031 ATLWYVPLSLKNVDK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATLWYVPLSLKNVDK 15 1 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 1 11776500.0 2639200.0 6958300.0 2179000.0 True False 3460016.758049154 5920148.763240957 1953537.9824439231 1.0 1.7110173670311608 0.5646036187250658 21.722347594670527 -6.738951054457295 1.6904722869940303 1.4235646941745348 0.5640761928215419 0.6002491623700597 0.29874764765807105 0.3197186403204411 1.7935571198358071 0.13982781262918456 0.34352932501662226 1.8241012692780186e-07 6.738951054457295 -0.8594885013529929 ATLWYVPLSLKNVDK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATLWYVPLSLKNVDK 15 1 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 1 24229900.0 9822900.0 10304000.0 4103000.0 True False 9511077.416283606 14418440.934650132 3028301.212638434 1.0 1.5159629454771117 0.3183972835142503 23.18117734837906 -6.789621324210978 1.4978957184899606 1.2885100271729237 0.3058005885048277 0.800092161406476 0.21929006195828035 0.2359093821858795 1.0456822454371315 0.11523698554179673 0.26986679059309154 1.623224824154524e-07 6.789621324210978 -0.982709438668096 down ATLWYVPLSLKNVDK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATLWYVPLSLKNVDK 15 1 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 1 12983100.0 9822900.0 0.0 3160200.0 True False 8168176.578253801 0.0 3820983.20888612 1.0 0.0 0.46778900679727625 22.961582623813335 -10.06500789695057 5.405941359724762 1.000006648663837 0.2338945033982164 0.7814757508461403 0.1909740623249341 1.555353253845973e-05 2.6899530953646382e-06 0.1849114705713664 0.06163661357819167 8.609780965325731e-11 10.06500789695057 -0.7661121452656207 ATLYVTAIEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATLYVTAIEDR 11 0 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;E9PNR9;H0YDE4 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 0 19868200.0 5878700.0 7204000.0 6785500.0 False True 7707032.629411781 6129191.280972057 6083401.551112093 1.0 0.7952725226024963 0.7893312307899742 22.87774406826264 ATLYVTAIEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATLYVTAIEDR 11 0 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;E9PNR9;H0YDE4 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 0 24833700.0 5878700.0 5714000.0 13241000.0 False True 8052214.255894015 5461536.586328829 10113748.506954996 1.0 0.6782651843039477 1.2560207895054445 22.94095412978553 -6.755562308747849 1.6290207809360442 0.8120870675281588 1.2576899668400838 0.672602369333404 0.13525106509071272 0.2904635024618157 1.5180665529844974 0.06553946871807953 0.15820917580678873 1.7556489910722312e-07 6.755562308747849 0.445602899311925 ATLYVTAIEDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATLYVTAIEDR 11 0 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;E9PNR9;H0YDE4 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 0 11558300.0 3798400.0 3255300.0 4504600.0 False True 3158537.8976513357 3237763.0527735422 5446491.033082848 1.0 1.025082857223628 1.7243709619988468 21.590825451792814 -6.914499954805777 0.8645311714316036 0.9813066384092153 1.8240112162166662 0.9925117185150328 0.029051124042906957 0.10151705463937037 0.12318356513664315 0.024326945928763 0.06944352844827405 1.217587119551681e-07 6.914499954805777 0.8427045778074509 ATLYVTAIEDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATLYVTAIEDR 11 0 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;E9PNR9;H0YDE4 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 0 33967400.0 9730000.0 14261000.0 9976400.0 False True 12595676.80697395 13467362.813573482 8160797.566508372 1.0 1.0692051741210842 0.6479046494738511 23.586425309096807 -6.864734173378575 1.161510009915851 1.0381377479290772 0.62557179495456 0.959143548239453 0.03728639457916188 0.14200822868070073 0.36138640472524713 0.024984028766904972 0.05867046448959899 1.3654186377934653e-07 6.864734173378575 -0.41256595297451726 ATNDSVVADK(ub)SCEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATNDSVVADKSCEK 14 1 P40306 P40306 PSMB10 Proteasome subunit beta type-10 1 11470800.0 2039600.0 2597000.0 6834200.0 True False 1696017.769600266 2583009.445535858 8263199.622229441 1.0 1.522984895461707 4.872118541645347 20.693719854779463 -6.934471997931631 0.7091209386086803 0.9565307676099204 5.6451486913663285 0.9973465322531581 0.08836360674606059 0.09038125735093251 0.06678523665124614 0.08276424165270099 0.2959421209945413 1.1628615265777194e-07 6.934471997931631 4.688617923756408 up ATNIEVLSNTFQFTNEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATNIEVLSNTFQFTNEAR 18 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 3796750.0 889930.0 978320.0 1928500.0 False True 1218961.1704539713 935094.587528389 1473028.0187042311 1.0 0.7671241793371782 1.208428992168503 20.217220739510584 -6.7633443192419485 1.5999971993993871 0.8652943626515446 1.210306196935114 0.7044119922552441 0.09800053723822116 0.2773427225019903 1.4000527563509575 0.048311458511303404 0.11571455583554205 1.7244701479408635e-07 6.7633443192419485 0.3450118342835695 ATNPLNK(ub)ELDWASINGFCEQLNEDFEGPPLATR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATNPLNKELDWASINGFCEQLNEDFEGPPLATR 33 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-2;B0QYR5;Q9UJY5-5 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 99015000.0 39370000.0 41208000.0 18437000.0 True False 59727168.332537316 33854110.44042647 14792918.868775813 1.0 0.5668125810341473 0.2476748736255949 25.831883989382288 -8.032291763704913 0.26773255037397836 1.1596159906033165 1.0761123460947358e-19 0.999464456313843 0.007134842067547342 0.0969649895722633 0.051262172619715204 0.06750907487765702 0.09485171750969841 9.283425067559597e-09 8.032291763704913 -1.1596159906033165 down ATNPLNK(ub)ELDWASINGFCEQLNEDFEGPPLATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATNPLNKELDWASINGFCEQLNEDFEGPPLATR 33 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-2;B0QYR5;Q9UJY5-5 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 60636400.0 39370000.0 12056000.0 9210400.0 True False 50965241.098721944 11385073.001924265 7534201.706684632 1.0 0.22338897563284105 0.14783019846978743 25.603010311474737 -13.999999999999998 0.32946494218827566 9.426730459962315 0.13436482323528656 0.9997137303757546 0.006516452937760277 18.778178610130148 0.1835187442459314 109.61795230851628 0.024261494039190052 1.0000000000000041e-14 13.999999999999998 -9.292365636727029 ATNVTYQAHHVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATNVTYQAHHVSR 13 0 O43252 O43252 PAPSS1 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 0 3929230.0 880730.0 1421200.0 1627300.0 False True 1154645.559001452 1209162.4997942115 1458922.6061638375 1.0 1.0472153037507945 1.2635241999506126 20.139018625513266 -6.941773344592175 0.6428553314808818 0.9976267694668773 1.3250301642412705 0.9983870575436086 0.004607663149742358 0.08696686478547654 0.05099507081682477 0.0045479446984607675 0.01847668948993347 1.1434749510792626e-07 6.941773344592175 0.3274033947743932 ATNVTYQAHHVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATNVTYQAHHVSR 13 0 O43252 O43252 PAPSS1 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 0 3244230.0 880730.0 1233700.0 1129800.0 False True 1206359.6818333194 1179191.0546996612 862964.5089613906 1.0 0.9774788335993045 0.7153459469483703 20.202228687036158 -6.923838535220145 0.7957379122950908 1.005023465695541 0.6691024297630196 0.9951824914119812 0.008967995592098292 0.09596558100580793 0.0942936509635452 0.007888307193908123 0.024570808319136946 1.1916849779392679e-07 6.923838535220145 -0.33592103593252143 ATNVVMNYSEIESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATNVVMNYSEIESK 14 0 Q14677;Q14677-3 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 0 7210100.0 1384700.0 1993800.0 3831600.0 False True 1815355.1094538749 1696332.8117715302 3435142.7873024987 1.0 0.9344358042883681 1.892270426548068 20.7918203569594 -6.890505196907056 1.0194266503461924 0.9491557393111097 1.9754616176733866 0.9812183540336787 0.05987472613810823 0.11873272962058047 0.21947935081762637 0.04472354251148865 0.11169723678946551 1.2867518552521616e-07 6.890505196907056 1.026305878362277 ATNVVMNYSEIESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATNVVMNYSEIESK 14 0 Q14677;Q14677-3 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 0 6022700.0 1384700.0 2357500.0 2280500.0 False True 1896661.010110474 2253337.8547900235 1741892.86837179 1.0 1.188055136251667 0.9183996819074858 20.85503041848229 -6.719171050225704 1.7621324526147626 1.1145096034753115 0.9188344911931566 0.5086910003605111 0.07914229245417796 0.3569238237785158 2.1654749223202923 0.035666379741537406 0.08962897774143315 1.9091011962672366e-07 6.719171050225704 -0.19567511228215484 ATPATEAGFEDEAK(ub)TSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATPATEAGFEDEAKTSAR 18 1 Q12772 Q12772 SREBF2 Sterol regulatory element-binding protein 2;Processed sterol regulatory element-binding protein 2 1 18988840.0 637340.0 1371500.0 16980000.0 True False 617107.9905622773 1919147.1022780167 12532428.610918995 1.0 3.1099048005024015 20.308323344671145 19.235163449736966 -6.929749976549579 0.7488528469119456 0.7360176951616633 23.816562442550186 0.9964886609671125 0.5124344936143957 0.09276806245691865 0.07832085783926238 0.46615793006255335 1.558308316776017 1.175574138514927e-07 6.929749976549579 23.080544747388522 ATPATEAGFEDEAK(ub)TSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATPATEAGFEDEAKTSAR 18 1 Q12772 Q12772 SREBF2 Sterol regulatory element-binding protein 2;Processed sterol regulatory element-binding protein 2 1 18958840.0 637340.0 2014500.0 16307000.0 True False 529976.4489493204 2003647.4886530584 19716718.304950938 1.0 3.7806349558084977 37.20300844318532 19.015568725171242 -6.923369625778635 0.7993334170327933 0.3482183828563335 43.033860002471286 0.9950669729792253 1.1553794474730146 0.09622955314226961 0.09563486475945006 1.0136730619877372 3.1415745963808956 1.1929723397052742e-07 6.923369625778635 42.685641619614955 ATPEEK(ub)EQGAAFNCEQGCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATPEEKEQGAAFNCEQGCK 19 1 O15287 O15287 FANCG Fanconi anemia group G protein 1 11703800.0 1407400.0 1898700.0 8397700.0 True False 1821907.0440015548 1793035.675908559 6869404.767678443 1.0 0.9841532156165421 3.770447449717737 20.79701792221876 -6.905617350940679 0.9250444307352987 0.9013238475277818 4.09873562080701 0.9891604202202062 0.1363626637719988 0.1073885833606446 0.15500785237748602 0.10927712242890912 0.29324254814012624 1.2427467872078765e-07 6.905617350940679 3.197411773279228 up ATPGLQK(ub)FSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATPGLQKFSK 10 1 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 3024530.0 789830.0 1031600.0 1203100.0 True False 1035474.7787246006 877689.3011453043 1078614.752950108 1.0 0.8476201634059679 1.0416620231722524 19.981860983286193 -6.6972558179922785 1.8404683243344502 0.9051263368176891 1.0410596753770807 0.40465589441270644 0.06435410274144247 0.4012554266156248 2.6404394590205893 0.027914677926118136 0.07203838913895062 2.0079097196431415e-07 6.6972558179922785 0.1359333385593916 ATPGLQK(ub)FSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATPGLQKFSK 10 1 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 4669800.0 1289300.0 1021600.0 2358900.0 True False 1248371.8772271392 1429530.207573619 1741033.32451689 1.0 1.1451156771881672 1.3946431798704417 20.25161633166034 -6.962888964159554 0.39260545491824145 0.985112860682059 1.563649253693415 0.9998627909239018 0.0019090921049911167 0.07868486860747621 0.01743316373969117 0.0032174491524733545 0.020966960114971563 1.0892085351073638e-07 6.962888964159554 0.578536393011356 ATPGLQK(ub)FSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATPGLQKFSK 10 1 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 16642200.0 2466500.0 2591700.0 11584000.0 True False 3741860.8253036155 2129190.8859554757 9294417.322552435 1.0 0.5690192621695684 2.483902463635398 21.835324469330377 -6.8476035264523505 1.2467113772211202 0.7704143237478005 2.5569374327515835 0.936729052220513 0.20630970013606834 0.1601141225759068 0.4801238458531362 0.12957119498964964 0.2993926065905558 1.4203535907916544e-07 6.8476035264523505 1.786523109003783 up ATPGLQK(ub)FSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATPGLQKFSK 10 1 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 3280770.0 789830.0 955140.0 1535800.0 True False 1081851.4953531856 912938.7565743988 1173075.6707938588 1.0 0.8438669822019862 1.0843222714323575 20.045071044809085 -6.731463737861297 1.7180133371513486 0.9061915465808554 1.0842142167053783 0.5659590504419096 0.0656274693422855 0.33351458616403556 1.929195408670771 0.030264228074994293 0.07497105407444467 1.855821757883017e-07 6.731463737861297 0.17802267012452289 ATPGLQK(ub)FSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATPGLQKFSK 10 1 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 5429900.0 1289300.0 1998600.0 2142000.0 True False 1072110.0756744584 1987833.1451089606 2589882.296510998 1.0 1.8541315767958118 2.4156869292378564 20.032021607094617 -8.3438972171 0.14878770298385535 2.5621096584216907e-17 3.4892252849811167 0.9999166276403483 0.005314619047337493 0.1017659782554694 0.03377546799000524 0.3616249057279857 0.348659014169256 4.5300477821597484e-09 8.3438972171 3.4892252849811167 ATPGLQK(ub)FSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATPGLQKFSK 10 1 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 18511000.0 2466500.0 2529500.0 13515000.0 True False 3192932.8719836865 2388731.1013907944 11055408.675610496 1.0 0.7481306990042473 3.4624619805245254 21.606450791422827 -6.884197967872498 1.056134393541313 0.8332318769211309 3.6709866081276754 0.9769158576718132 0.1860450253162306 0.12397540261716716 0.25037930792760965 0.13514586396765893 0.3305900318003684 1.3055756216563983e-07 6.884197967872498 2.8377547312065445 up ATPLSSTVTLSMSADVPLVVEYK ddPTM_RPMI8226_Bortezomib_8h_R1 2 ATPLSSTVTLSMSADVPLVVEYK 23 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 134195100.0 35668400.0 50120400.0 48406300.0 False True 54111570.509328716 41176023.02752742 38838773.587765045 1.0 0.7609467372681183 0.7177535824998709 25.689433778256713 -13.999999999999998 0.2406483392727734 2.5872892679946005 0.6987730049746311 0.9995260387080771 0.0027023930542782212 13.646368129940798 0.15525948399488518 10.413189110024026 0.021025673933661018 1.0000000000000041e-14 13.999999999999998 -1.8885162630199694 ATPLSSTVTLSMSADVPLVVEYK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ATPLSSTVTLSMSADVPLVVEYK 23 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 78309400.0 35668400.0 12596600.0 30044400.0 False True 46173446.92927741 11895588.136698663 24576627.481576886 1.0 0.2576283324681999 0.5322675502052127 25.460560100349163 -10.367971097567937 5.848928023889824 1.00012164693854 0.3949479413386127 0.8661565081566137 0.1121209911354716 0.00017789043376284662 1.9222600380865794e-05 0.10858221411604672 0.03618689428566206 4.2857704138301756e-11 10.367971097567937 -0.6051737055999273 ATQALVLAPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATQALVLAPTR 11 0 P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 30273300.0 2334300.0 14017000.0 13922000.0 False True 3060289.9053933565 11925718.237838069 12481484.989253938 1.0 3.896924345899572 4.0785302618738735 21.5452368971644 -10.18940495884655 0.5981285866146037 1.6670863723668982e-15 4.058048458558435 0.9996796768985874 0.025242345388548776 1.4825948931888684 0.28717259397025874 2.5880434124989344 0.03156740065122519 6.465394674378386e-11 10.18940495884655 4.058048458558433 ATQALVLAPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATQALVLAPTR 11 0 P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 11240900.0 4269400.0 1469200.0 5502300.0 False True 4133870.2339514056 2055859.2217767856 4061082.564538252 1.0 0.4973206959647763 0.9823923671296332 21.9790616712532 -10.78547163809967 10.249598194697038 1.0016458240925061 0.7398565315472048 0.2771897041923511 0.19802968050550193 0.007483547999920327 0.00015663356311792308 0.19266410149448093 0.06391380455438204 1.6388090813461328e-11 10.78547163809967 -0.26178929254530137 ATQALVLAPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATQALVLAPTR 11 0 P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 21444400.0 2334300.0 8863100.0 10247000.0 False True 3197353.7920855633 8471498.935647713 7826869.643589461 1.0 2.6495344233150817 2.447921047387179 21.608446958687292 -9.870675741731697 6.772165763303169 0.9999999651778174 2.548727735351168 0.9874493954640816 0.08230831605735 4.3311686859148606e-08 7.364973522878112e-09 0.07969468552358226 0.02656489477868772 1.3468655920316937e-10 9.870675741731697 1.5487277701733504 ATSILEFYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATSILEFYR 9 0 D6RC14;E9PF06;H0Y9G6;E7ETU7;P09001 D6RC14 MRPL3 39S ribosomal protein L3, mitochondrial 0 3241230.0 860590.0 811340.0 1569300.0 False True 1178773.3795702856 775492.3160574078 1198663.6607480154 1.0 0.6578807508701194 1.016873710861184 20.168854954651366 -11.029128898063426 12.027672053659122 1.3643629294679145 0.8373772308656517 0.2148293572269453 0.1465582622049141 0.046309893218589374 0.00011215448512660951 0.004589260403074202 0.047301475730727696 9.351280880996005e-12 11.029128898063426 -0.5269856986022627 ATSNVFAMFDQSQIQEFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATSNVFAMFDQSQIQEFK 18 0 J3QRS3;P19105;O14950;P24844;J3KTJ1;P24844-2 J3QRS3 MYL12A;MYL12B;MYL9 Myosin regulatory light chain 12A;Myosin regulatory light chain 12B;Myosin regulatory light polypeptide 9 0 5112860.0 756660.0 2643200.0 1713000.0 False True 991988.5875058622 2248844.863112905 1535755.1922562832 1.0 2.2670067896316555 1.5481581256066694 19.91996399742456 -10.249928704421164 5.426607107252074 0.9999228194163807 1.9075824576191887 0.6800386031252585 0.29346873819066116 207312016.6813614 26.117678915209755 199946.22929185964 0.10046215489346313 5.6243364904663804e-11 10.249928704421164 0.9076596382028079 ATSNVFAMFDQSQIQEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATSNVFAMFDQSQIQEFK 18 0 J3QRS3;P19105;O14950;P24844;J3KTJ1;P24844-2 J3QRS3 MYL12A;MYL12B;MYL9 Myosin regulatory light chain 12A;Myosin regulatory light chain 12B;Myosin regulatory light polypeptide 9 0 19297200.0 7014200.0 3272600.0 9010400.0 False True 6791538.060378964 4579366.246383551 6650305.933794145 1.0 0.6742752828109785 0.9792046918784493 22.695306903853453 -10.51554876810695 8.651552285998898 1.000011154321991 0.8267399876500665 0.3009261127235314 0.12448690996395093 2.6784968665581672e-05 1.499819433118568e-06 0.12054168677899102 0.040177977425933695 3.0510633977080484e-11 10.51554876810695 -0.17327116667192444 ATSNVFAMFDQSQIQEFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATSNVFAMFDQSQIQEFK 18 0 J3QRS3;P19105;O14950;P24844;J3KTJ1;P24844-2 J3QRS3 MYL12A;MYL12B;MYL9 Myosin regulatory light chain 12A;Myosin regulatory light chain 12B;Myosin regulatory light polypeptide 9 0 5128560.0 756660.0 1252700.0 3119200.0 False True 1036417.6499676389 1197351.5718750644 2382509.201940489 1.0 1.1552790247372289 2.2987925784695777 19.98317405894745 -6.931670804804149 0.7329504676090614 0.9836438330056608 2.543858885772954 0.9968565322719734 0.03247026316005349 0.09177941384807407 0.07349839473578225 0.029881623864240297 0.10253406587141556 1.1703862075615374e-07 6.931670804804149 1.560215052767293 up ATSNVFAMFDQSQIQEFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATSNVFAMFDQSQIQEFK 18 0 J3QRS3;P19105;O14950;P24844;J3KTJ1;P24844-2 J3QRS3 MYL12A;MYL12B;MYL9 Myosin regulatory light chain 12A;Myosin regulatory light chain 12B;Myosin regulatory light polypeptide 9 0 11398000.0 7014200.0 2369800.0 2014000.0 False True 5832618.081746518 2357033.4170315294 2435118.0883161305 1.0 0.4041124215569657 0.4175000067185883 22.47571217928773 -10.065857947539245 5.373396649842507 1.0000056330318954 0.4108062141372331 0.9996129368792139 0.005465458757579514 3.6883008100159023e-07 6.41170932295885e-08 0.005291958285063418 0.001763969228681597 8.592945403722248e-11 10.065857947539245 -0.5891994188946623 ATSSHPNSTSLK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATSSHPNSTSLKAK 14 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 11146900.0 3351700.0 4653800.0 3141400.0 True False 4394111.157908975 3959471.180370316 2816358.0624365974 1.0 0.9010858028121684 0.6409391936677399 22.06713993542938 -6.954366208039109 0.5086580018485004 1.0048411158441106 0.5257969472242583 0.9995008712199912 0.0033831668779095323 0.08177845040669587 0.02906242072821692 0.003905833744838562 0.021468664524497888 1.1107946822303828e-07 6.954366208039109 -0.47904416861985233 ATSSHPNSTSLK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATSSHPNSTSLKAK 14 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 11891700.0 2704600.0 4547100.0 4640000.0 True False 2618743.9534231937 6362780.742813241 3424644.8029837552 1.0 2.429707087054419 1.3077432784167757 21.320443577013894 -6.5851805989202425 2.245883464278828 1.970462519338325 1.3106722558609225 0.0 0.6202753519717975 0.6837751051104518 6.494003235718152 0.23112551406332446 0.6927521935763261 2.5990785262069176e-07 6.5851805989202425 -0.6597902634774024 ATSSHPNSTSLK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATSSHPNSTSLKAK 14 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 10164600.0 3351700.0 3405800.0 3407100.0 True False 4590914.066286763 3255320.4945255043 2602413.151427111 1.0 0.7090789432176156 0.566861656274042 22.130349996952273 -13.999999999672447 0.09394787023584149 2.466040034733882 0.23338766251824664 0.9998235831658643 0.0023943514202959897 12.129211592120464 0.08999980288534569 3.506234619589719 0.2986278106238958 1.0000000007542189e-14 13.999999999672447 -2.2326523722156355 ATSSHPNSTSLK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATSSHPNSTSLKAK 14 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 9362800.0 2704600.0 4761200.0 1897000.0 True False 2248994.734095356 4735550.470575794 2293653.9292630106 1.0 2.1056298615481817 1.0198574031724528 21.10084885244817 -6.64199006466555 2.0373942709600388 1.721937975314766 1.0244018581402168 0.16220114065300428 0.4728345803118062 0.5283951121259887 4.194445283027114 0.18883811710960935 0.5235541178393017 2.280394239875538e-07 6.64199006466555 -0.6975361171745491 ATSSPPDK(ub)VLNGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATSSPPDKVLNGQR 14 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 3494240.0 621540.0 1235100.0 1637600.0 True False 814844.9590019214 1050827.8943820933 1468156.8609684135 1.0 1.2896047067275476 1.8017622183816586 19.636166057513933 -6.962377605988866 0.4005184094771283 0.9720065279495353 2.1380769116207783 0.9998484705972861 0.004080605976806008 0.07886246484723215 0.01807150783886845 0.0065895380834962046 0.04290213981243326 1.0904917743385298e-07 6.962377605988866 1.166070383671243 ATSSPPDK(ub)VLNGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATSSPPDKVLNGQR 14 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 2075100.0 621540.0 516340.0 937220.0 True False 851340.134486938 493526.39149195387 715867.9386517905 1.0 0.5797053040256097 0.8408718321299511 19.699376119036824 -10.352927624179626 6.1246027192423815 1.000031543101989 0.7102885680777804 0.6213156682205572 0.10662078862498026 4.5927623783333075e-05 4.8521747607661225e-06 0.1032463554840674 0.03441171155867073 4.436825781311914e-11 10.352927624179626 -0.28974297502420865 ATSSPPDK(ub)VLNGQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATSSPPDKVLNGQR 14 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 5436600.0 1120900.0 3208800.0 1106900.0 True False 932078.0142895383 3191513.5575030665 1338347.6722726559 1.0 3.4240841523718886 1.4358751646907906 19.830091186954018 -6.5971208418767615 2.201273296888055 2.633250780008566 1.4420864931737556 0.01242489999256724 1.0485259085003735 0.6489462595139717 5.938330858428466 0.3959900581400014 1.1671969169257304 2.528594320459507e-07 6.5971208418767615 -1.1911642868348105 ATSSSSGSLSATGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATSSSSGSLSATGR 14 0 Q03252 Q03252 LMNB2 Lamin-B2 0 7122270.0 562570.0 3530400.0 3029300.0 False True 737534.7179356306 3003678.0813914156 2715857.095097469 1.0 4.072592121220747 3.682344748053609 19.492351437310063 -10.259805119251801 5.039005281977227 0.9994640010190614 3.877468434638562 0.9863927619905987 0.15931782295831537 0.0009594870907289221 0.0001409427888554758 0.15428146148612326 0.05141960625527455 5.497875243978689e-11 10.259805119251801 2.8780044336195005 ATSSSSGSLSATGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATSSSSGSLSATGR 14 0 Q03252 Q03252 LMNB2 Lamin-B2 0 5047920.0 1752500.0 709120.0 2586300.0 False True 1696867.8467699997 992275.3140119477 1908870.4426631192 1.0 0.5847687643447019 1.124937599764571 20.694442780501976 -6.701399696709536 1.8263291028174373 0.7425061055436429 1.123349734424887 0.42403965479338257 0.1752302660509515 0.3926061093825462 2.546980716503736 0.07652411088049178 0.19642757476748093 1.9888420940852218e-07 6.701399696709536 0.3808436288812441 ATSSSSGSLSATGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATSSSSGSLSATGR 14 0 Q03252 Q03252 LMNB2 Lamin-B2 0 5758270.0 562570.0 2817000.0 2378700.0 False True 770567.3318826105 2692535.6254267264 1816900.0508642765 1.0 3.4942249872551203 2.357873187311639 19.555561498832954 -8.971805015921602 11.485296967082585 1.0000037392703274 2.9260478443595668 0.7929792066233787 0.4639136797040147 0.0 0.0 0.44918248888965073 0.14972749629655022 1.0670750956660142e-09 8.971805015921602 1.9260441050892394 ATSTTELPPEYLTSPLSQQSQLPPK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATSTTELPPEYLTSPLSQQSQLPPKR 26 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 79889000.0 19121000.0 29296000.0 31472000.0 True False 25067816.168027423 24925150.994913615 28215579.34074123 1.0 0.9943088312058165 1.1255699001306942 24.579332982649504 -6.896765755097074 0.9814999084480204 0.994047883946455 1.1384771504079692 0.9848870093135356 0.007447420207673626 0.11382486390301892 0.1911552673397587 0.005723777794244706 0.014664573867273384 1.268335782175905e-07 6.896765755097074 0.1444292664615141 ATSTTELPPEYLTSPLSQQSQLPPK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATSTTELPPEYLTSPLSQQSQLPPKR 26 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 160514000.0 52917000.0 43467000.0 64130000.0 True False 51237178.80030138 60823599.77741046 47332429.141238816 1.0 1.1870989231173807 0.923790697487825 25.610687705018606 -6.715880709814367 1.774087349494942 1.1143297155355683 0.9242929628050203 0.4929483609898526 0.07877481724900162 0.36342710482185603 2.2331161089307345 0.035287431126512135 0.08901840495405904 1.9236200282275833e-07 6.715880709814367 -0.190036752730548 ATSTTELPPEYLTSPLSQQSQLPPK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATSTTELPPEYLTSPLSQQSQLPPKR 26 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 163361000.0 55318000.0 73269000.0 34774000.0 True False 83921450.28751081 60193574.496690154 27900903.65801434 1.0 0.7172608944491532 0.3324645077322567 26.322536274258752 -6.994948435676066 0.3298985003241652 1.0478192715500183 1.978729389970333e-10 0.9999460268702143 0.002009884401989936 0.07424816708435848 0.012771528296950385 0.00560115836859435 0.032347177900004166 1.0116995674769791e-07 6.994948435676066 -1.0478192713521455 down ATSTTELPPEYLTSPLSQQSQLPPK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATSTTELPPEYLTSPLSQQSQLPPKR 26 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 76163000.0 19121000.0 23555000.0 33487000.0 True False 26190550.42559573 22514262.214031417 25578060.28641359 1.0 0.8596330297826991 0.9766140791533896 24.642543044172395 -10.17849699966902 4.755452376914157 1.0000072043017898 0.9181235544824663 0.39510122114864543 0.047757313454023634 5.140573412096222e-06 8.880650939741121e-07 0.046246552507127565 0.01541360663414768 6.629839278908403e-11 10.17849699966902 -0.0818836498193235 ATSTTELPPEYLTSPLSQQSQLPPK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATSTTELPPEYLTSPLSQQSQLPPKR 26 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 125004000.0 52917000.0 42160000.0 29927000.0 True False 44002830.12058121 41932875.711895175 36184597.333186105 1.0 0.9529586073665324 0.8223243194592085 25.391092980452882 -6.953172980439694 0.5228503704577058 1.002171923540989 0.7672527792910552 0.9994273341121113 0.0017987020266870693 0.08223608813518232 0.030878820176240475 0.0020285766515080613 0.010793623537860602 1.1138507960244978e-07 6.953172980439694 -0.23491914424993376 ATSTTELPPEYLTSPLSQQSQLPPK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATSTTELPPEYLTSPLSQQSQLPPKR 26 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 133186000.0 55318000.0 49298000.0 28570000.0 True False 71610241.48080015 46554522.9635752 23370553.152955372 1.0 0.6501098446380356 0.32635769227536243 26.0936625963512 -7.432564208123396 0.26164226137894603 1.1160977776735321 2.900031596576858e-14 0.9998725915720683 0.003104995702029607 0.12080999202613549 0.022985648141530444 0.021770037946028185 0.05949529924606979 3.69348034184062e-08 7.432564208123396 -1.116097777673503 down ATTLPTDFNYNVDTLVQLHLKPGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATTLPTDFNYNVDTLVQLHLKPGTR 25 1 E9PHA2;Q15003;Q15003-2;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 0 61204000.0 17586000.0 25861000.0 17757000.0 False True 26679247.708813854 21245902.497084785 14247321.166830434 1.0 0.7963456364650758 0.5340225977257835 24.669214650746582 -6.967664559650708 0.30892007570124763 1.0409318921896353 0.28111086726708395 0.9999580086627549 0.001235972270921459 0.07706800845206621 0.011728805086992311 0.004170889436904681 0.02331378026563421 1.0772969749519533e-07 6.967664559650708 -0.7598210249225514 ATTLPTDFNYNVDTLVQLHLKPGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATTLPTDFNYNVDTLVQLHLKPGTR 25 1 E9PHA2;Q15003;Q15003-2;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 0 54118000.0 17586000.0 22152000.0 14380000.0 False True 22765423.671885304 20919221.726827025 11762987.551259989 1.0 0.9189032467979812 0.5167040912920486 24.44034097283903 -6.939986788781828 0.6596857463469233 1.0045155360162428 0.40828567544975136 0.9981621780699331 0.009059367981710689 0.08777264525302889 0.05463697151786784 0.00881773585404934 0.03461848754252563 1.1481885488085021e-07 6.939986788781828 -0.5962298605664914 ATTLSNAVSSLASTGLSLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATTLSNAVSSLASTGLSLTK 20 0 Q13492-3;Q13492-2;Q13492-4;Q13492;Q13492-5 Q13492-3 PICALM Phosphatidylinositol-binding clathrin assembly protein 0 17948600.0 8544700.0 3340800.0 6063100.0 False True 8273453.175632303 4674798.862041845 4474992.220898872 1.0 0.5650359967964128 0.5408856647764697 22.980058176779544 -13.999999999999998 0.411805534334391 8.912044994740961 0.5398503431906395 0.9998537907909174 0.0025509406581394065 28.595554364425503 0.2129604194908101 203.02547775557946 0.005985984114874066 1.0000000000000041e-14 13.999999999999998 -8.372194651550322 ATTLSNAVSSLASTGLSLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATTLSNAVSSLASTGLSLTK 20 0 Q13492-3;Q13492-2;Q13492-4;Q13492;Q13492-5 Q13492-3 PICALM Phosphatidylinositol-binding clathrin assembly protein 0 15998300.0 8544700.0 2250800.0 5202800.0 False True 7105296.644392723 2238674.493651183 6290681.424970788 1.0 0.3150712216101314 0.8853509909308567 22.76046345221382 -10.33271702359656 8.140317896770469 1.0000014788876077 0.6002111062706162 0.39587113851487343 0.23281574091131227 6.248762982954985e-06 5.120964068177702e-07 0.22542370805534934 0.07514095727370446 4.6481804143461583e-11 10.33271702359656 -0.39979037261699146 ATTLSNAVSSLASTGLSLTK(ub)VDER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATTLSNAVSSLASTGLSLTKVDER 24 1 Q13492-3;Q13492-2;Q13492-4;Q13492;Q13492-5 Q13492-3 PICALM Phosphatidylinositol-binding clathrin assembly protein 1 161471000.0 75892000.0 45010000.0 40569000.0 True False 73482850.0011805 62982727.724049225 29942761.856087863 1.0 0.8571078520095152 0.4074795936141131 26.130904246061366 -6.950373051580627 0.5547316480819694 1.006050847332453 0.23724150971825925 0.9992302434470569 0.0070046131883661905 0.08333626472674545 0.03534489598283725 0.007557244994892441 0.03733500466654471 1.1210550733377048e-07 6.950373051580627 -0.7688093376141938 down ATTLSNAVSSLASTGLSLTK(ub)VDER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATTLSNAVSSLASTGLSLTKVDER 24 1 Q13492-3;Q13492-2;Q13492-4;Q13492;Q13492-5 Q13492-3 PICALM Phosphatidylinositol-binding clathrin assembly protein 1 249221000.0 88019000.0 102900000.0 58302000.0 True False 133531258.05084082 84536691.0386304 46778584.14532565 1.0 0.6330854084100953 0.3503193546451508 26.99260225798798 -7.759466079617781 0.2146869505321992 1.2010618351475013 9.645413842917393e-11 0.9998643834343812 0.0030973539608393354 0.12743786079136363 0.02944564374772967 0.05097112990416724 0.08594316458408983 1.7399385898805394e-08 7.759466079617781 -1.2010618350510471 down ATTLSNAVSSLASTGLSLTK(ub)VDER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATTLSNAVSSLASTGLSLTKVDER 24 1 Q13492-3;Q13492-2;Q13492-4;Q13492;Q13492-5 Q13492-3 PICALM Phosphatidylinositol-binding clathrin assembly protein 1 14980500.0 6913800.0 2863300.0 5203400.0 True False 9470018.698419722 2736789.938333099 3974464.0873868745 1.0 0.28899519900523446 0.41968914887677045 23.174935843601865 -10.765905911642548 6.175407140809117 1.0231406798868337 0.3543421739410026 0.9701858566186371 0.05335558160902437 0.015886851659091577 0.0006022297533493148 0.04828141339811251 0.01722043991658017 1.7143286704991207e-11 10.765905911642548 -0.668798505945831 ATTLSNAVSSLASTGLSLTK(ub)VDER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATTLSNAVSSLASTGLSLTKVDER 24 1 Q13492-3;Q13492-2;Q13492-4;Q13492;Q13492-5 Q13492-3 PICALM Phosphatidylinositol-binding clathrin assembly protein 1 127444000.0 75892000.0 34842000.0 16710000.0 True False 63107560.585655764 34654299.230404474 20203983.741689466 1.0 0.5491307049235133 0.32015155639341564 25.911309521495642 -10.123416725992344 0.1538749273464789 1.732407170395928 2.001024060844971e-11 0.9997048478592401 0.004852169322794593 1.7251934298091056 0.07326002439121697 0.6965260495038983 0.1936352029970605 7.526330303268737e-11 10.123416725992344 -1.7324071703759178 ATTLSNAVSSLASTGLSLTK(ub)VDER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATTLSNAVSSLASTGLSLTKVDER 24 1 Q13492-3;Q13492-2;Q13492-4;Q13492;Q13492-5 Q13492-3 PICALM Phosphatidylinositol-binding clathrin assembly protein 1 189504000.0 88019000.0 78976000.0 22509000.0 True False 113942330.6138788 74580916.17451648 18412592.961843606 1.0 0.6545496811650447 0.16159572006859452 26.76372858008043 -7.417656828056387 0.46366737969504895 1.0192075349356733 2.3290304122196185e-23 0.998376663126523 0.013861527875303474 0.1120455928199428 0.053161476225901796 0.017285445435201455 0.06294040737690947 3.8224619582990934e-08 7.417656828056387 -1.0192075349356733 down ATTTYDFDCDNLELK(ub)SNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATTTYDFDCDNLELKSNK 18 1 Q6P0N0 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 32225600.0 10299000.0 11994000.0 9932600.0 True False 13502088.73565788 10204541.952245833 8904869.832226943 1.0 0.7557750620684707 0.6595179461907943 23.686679269671373 -13.999999999999998 0.12861772405198224 2.160492624400435 0.5223198106151457 0.9996519170524449 0.0026737219600827078 11.939075516862772 0.11138754005421753 3.5071014143179813 0.12195546247087545 1.0000000000000041e-14 13.999999999999998 -1.6381728137852893 ATTTYDFDCDNLELK(ub)SNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATTTYDFDCDNLELKSNK 18 1 Q6P0N0 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 25020100.0 9472200.0 10169000.0 5378900.0 True False 9171510.195820145 14229534.730634434 3970004.7264588973 1.0 1.5514930940293181 0.43286270654403247 23.128727879222172 -6.772659092129815 1.564359182620418 1.3152469348030358 0.42594125994433824 0.7405983754740306 0.23260095291020233 0.26215116904130426 1.2664703535051172 0.11717584245097423 0.2782427483628795 1.6878774376148874e-07 6.772659092129815 -0.8893056748586976 down ATTTYDFDCDNLELK(ub)SNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATTTYDFDCDNLELKSNK 18 1 Q6P0N0 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 55379900.0 30354000.0 16389000.0 8636900.0 True False 46049237.17464664 13464254.90215855 6929812.929312245 1.0 0.2923882289535857 0.15048702985090048 25.45667392186431 -13.999999999993216 0.22588046184796667 5.38345906049522 0.07873235053388694 0.9995044532641626 0.00827128732542489 13.166314765652714 0.15051528714496243 25.825234674290655 0.07559444401129299 1.0000000000156205e-14 13.999999999993216 -5.304726709961333 ATTTYDFDCDNLELK(ub)SNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATTTYDFDCDNLELKSNK 18 1 Q6P0N0 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 39876000.0 10299000.0 16177000.0 13400000.0 True False 14106818.620009953 15462246.649814742 10235195.981662784 1.0 1.0960831826307151 0.7255495556698072 23.749889331194264 -6.837843143342588 1.2922616744384472 1.0511391911662045 0.7138654616317932 0.9206967585107555 0.0442134207384399 0.17133587544958856 0.5567044939207847 0.026836457597710837 0.06179872615809173 1.4526361798884046e-07 6.837843143342588 -0.33727372953441126 ATTTYDFDCDNLELK(ub)SNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATTTYDFDCDNLELKSNK 18 1 Q6P0N0 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 23012400.0 9472200.0 4609500.0 8930700.0 True False 7876553.989609562 4584667.708585891 10798068.079108689 1.0 0.582065166395584 1.3709127231722238 22.90913315465645 -6.762761048189468 1.6019070709543624 0.7580690014004321 1.3742090236973836 0.70214932670922 0.1758627210619283 0.2783309262430629 1.4082308762928324 0.08659132747150405 0.20754343989292318 1.7267877211440533e-07 6.762761048189468 0.6161400222969515 ATTTYDFDCDNLELK(ub)SNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATTTYDFDCDNLELKSNK 18 1 Q6P0N0 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 71448000.0 30354000.0 20388000.0 20706000.0 True False 39293851.366792135 19253389.87750762 16937720.46150138 1.0 0.489984799346469 0.43105269329276585 25.22780024395676 -13.999999999999998 0.3045641573405516 5.77637787239098 0.41722676242195134 0.9996599878563884 0.004710334667285864 16.891769181339615 0.17540609558147205 50.97499029845975 0.020888100957927546 1.0000000000000041e-14 13.999999999999998 -5.359151109969028 ATVAAFAASEGHSHPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATVAAFAASEGHSHPR 16 0 Q9NUP9;H0YI92;H0YIA8;O14910 Q9NUP9 LIN7C;LIN7A Protein lin-7 homolog C;Protein lin-7 homolog A 0 2156470.0 848960.0 721350.0 586160.0 False True 1112994.781340336 613727.3918002778 525509.7860437499 1.0 0.5514198288164388 0.4721583558647949 20.086015397446932 -13.999999999999998 0.24381672342194102 4.025038550320933 0.43836005176270393 0.999531461643544 0.005030652008644596 13.761286858359158 0.15626501033195997 20.31363949909704 0.03788030538152591 1.0000000000000041e-14 13.999999999999998 -3.5866784985582294 ATVAPEDVSEVIFGHVLAAGCGQNPVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATVAPEDVSEVIFGHVLAAGCGQNPVR 27 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 11520100.0 6160600.0 2427600.0 2931900.0 False True 5965035.125141941 3396953.339766762 2163947.434885357 1.0 0.5694775082629425 0.3627719517969921 22.508099202587324 -11.879852203595805 0.12172594066270309 2.279012430551582 2.209342492677521e-11 0.9997602944119581 0.0041096868757140225 5.212533403084161 0.0843982916715457 1.994638008802644 0.2702316546126768 1.318705435857266e-12 11.879852203595805 -2.2790124305294888 ATVAPEDVSEVIFGHVLAAGCGQNPVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATVAPEDVSEVIFGHVLAAGCGQNPVR 27 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 5830480.0 952180.0 1643100.0 3235200.0 False True 1304226.6776969668 1570502.4089949052 2471112.3910354814 1.0 1.2041636901402248 1.89469547992917 20.31476320451328 -6.9487280358174885 0.5726361007098316 0.9914974094682457 2.1410873492682714 0.9990976599676281 0.011499678575553668 0.08400052369903097 0.03810719374692908 0.012146892614600212 0.057572645616404745 1.1253094454042643e-07 6.9487280358174885 1.1495899398000256 ATVECVK(ub)DQFGFINYEVGDSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATVECVKDQFGFINYEVGDSK 21 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 29135600.0 6483600.0 10743000.0 11909000.0 True False 9836095.21465173 8825827.714557879 9555180.930099871 1.0 0.8972897803399698 0.9714404671344161 23.22965426979711 -10.122581468987809 4.4146161923141705 1.0000073223425905 0.9343651237361067 0.5109227073778904 0.030271891143727272 2.6172844530154365e-06 5.201938918547154e-07 0.029314554745262168 0.009770210851453845 7.54081924895777e-11 10.122581468987809 -0.06564219860648379 ATVECVK(ub)DQFGFINYEVGDSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATVECVKDQFGFINYEVGDSK 21 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 27639800.0 6483600.0 9341200.0 11815000.0 True False 8393148.010862926 8821354.008425264 9664791.232137464 1.0 1.051018520942098 1.1515096861902947 23.00078059188956 -6.960342309320699 0.4305821570340699 0.9960328969541763 1.2103526891534973 0.9997826771416586 0.0009278818869394251 0.07957908617777568 0.020681158249110865 0.0013111178233467062 0.008342757599890232 1.0956142965491284e-07 6.960342309320699 0.21431979219932096 ATVEDEK(ub)LQGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATVEDEKLQGK 11 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 16349400.0 5962800.0 6070900.0 4315700.0 True False 7817288.543837333 5165145.384182855 3869152.763117596 1.0 0.6607336233296308 0.49494818330171486 22.898236859376862 -13.999999997363174 0.09401650317826048 2.7092267106255226 0.10664515629354614 0.9998232508619361 0.0027945669151007587 12.12866632079358 0.09004858126255497 4.089795926689991 0.3477102778429396 1.0000000060715159e-14 13.999999997363174 -2.6025815543319766 ATVEDEK(ub)LQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATVEDEKLQGK 11 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 10969200.0 1724600.0 7558400.0 1686200.0 True False 1669853.5169983113 10576508.536535282 1244533.6350843103 1.0 6.333794209415063 0.7452950946987579 20.67129012138338 -6.656738301272261 1.984329206308559 4.442471282334896 0.7686433503050001 0.22186393237010538 2.2727900929320297 0.49224087874749556 3.7223892913492755 0.9264509674805164 2.5189012321517312 2.2042543104179665e-07 6.656738301272261 -3.673827932029896 ATVEDEK(ub)LQGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATVEDEKLQGK 11 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 60361600.0 18098400.0 24983900.0 17279300.0 True False 27456595.97027163 20525327.844898332 13864038.781213768 1.0 0.747555445952657 0.5049438319384139 24.710649437503413 -6.971609999970632 0.2163201252968873 1.11721310927687 0.12846471033755102 0.9999923609968435 0.0005586020867692795 0.07578380428778625 0.007131189100947325 0.006913474042703068 0.024785474343755717 1.0675543635410474e-07 6.971609999970632 -0.988748398939319 ATVEDEK(ub)LQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATVEDEKLQGK 11 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 15840000.0 5962800.0 4731500.0 5145700.0 True False 8167408.298611052 4522446.685021848 3930391.6390180797 1.0 0.5537186974956223 0.48122874421332423 22.961446920899753 -13.999999999999998 0.2557776844235514 4.196336853872579 0.45364271995593963 0.9995538431511715 0.004845103233520433 14.234521188809174 0.16003310768402396 23.457476964685235 0.03241239977138206 1.0000000000000041e-14 13.999999999999998 -3.7426941339166397 ATVEDEK(ub)LQGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATVEDEKLQGK 11 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 13663130.0 1724600.0 10138700.0 1799830.0 True False 1434081.3127341734 10084080.81072562 2176166.131526328 1.0 7.031735732961777 1.5174635581697384 20.451695396817655 -6.624810465380447 2.09886860817089 4.988694726731884 1.5389913515705118 0.09918877616172839 2.5906996045676305 0.5727169768997419 4.800601374322056 1.0118387291007478 2.871745995565366 2.3724088454622553e-07 6.624810465380447 -3.4497033751613726 ATVEDEK(ub)LQGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATVEDEKLQGK 11 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 57040500.0 18098400.0 27474000.0 11468100.0 True False 23428735.57279934 25945047.748413034 9381023.472642902 1.0 1.107402815990425 0.4004067331544016 24.481775759595862 -6.868179997651922 1.1437415496775034 1.060118235981898 0.3604196527713282 0.9628294942102711 0.05997356397778672 0.13860859392111516 0.3400319290440913 0.04073948358057996 0.09615495682379986 1.354627857048156e-07 6.868179997651922 -0.6996985832105698 down ATVGILITTIASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATVGILITTIASK 13 0 Q92973-2;Q92973 Q92973-2 TNPO1 Transportin-1 0 6491700.0 1859500.0 2082100.0 2550100.0 False True 2437822.507423616 1771458.7959622338 2286240.1142864865 1.0 0.7266561821329557 0.9378205785386207 21.217161659604947 -9.839097239855752 5.497169120067893 1.0000000696649032 0.832238380766802 0.4569806837770811 0.08620750384476472 7.357307393445497e-08 1.5612094132209804e-08 0.08347009025747257 0.027823352224969258 1.448447505431775e-10 9.839097239855752 -0.16776168889810117 ATVGILITTIASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATVGILITTIASK 13 0 Q92973-2;Q92973 Q92973-2 TNPO1 Transportin-1 0 11091100.0 4810700.0 3238000.0 3042400.0 False True 4657986.961744048 4530950.285946927 2245504.169956414 1.0 0.9727271293714495 0.4820760960472183 22.1512751706047 -6.918358880114009 0.8368082768415138 1.0114795482730647 0.4058657201133804 0.993712740483268 0.018870283077153088 0.09914719284935393 0.11068900442502465 0.016118921696674688 0.04755167130953998 1.2068161679965586e-07 6.918358880114009 -0.6056138281596843 down ATVGILITTIASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATVGILITTIASK 13 0 Q92973-2;Q92973 Q92973-2 TNPO1 Transportin-1 0 66435000.0 14242000.0 25163000.0 27030000.0 False True 21606155.229667157 20672466.050583664 21687508.65233014 1.0 0.9567859635757197 1.0037652891871887 24.364939034669632 -9.901879737103526 4.346427863161966 1.0000003215668822 0.9802756265139939 0.19030600398398734 0.019179229411635024 13088737.272388741 53.86452067991016 43.59016786500133 0.00656556035874979 1.2534882372736988e-10 9.901879737103526 -0.01972469505288832 ATVGILITTIASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATVGILITTIASK 13 0 Q92973-2;Q92973 Q92973-2 TNPO1 Transportin-1 0 8844600.0 1859500.0 2495400.0 4489700.0 False True 2547007.4010980194 2385144.976815707 3429325.328273987 1.0 0.9364499591903294 1.3464135702140476 21.28037172112784 -6.867319822611372 1.1482398549870507 0.9645826889974487 1.3692250564174473 0.9619310296513706 0.035151054546867365 0.1394473322791485 0.34531119771337254 0.023795543989478758 0.05608687481626687 1.3573135272844277e-07 6.867319822611372 0.4046423674199986 ATVGILITTIASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATVGILITTIASK 13 0 Q92973-2;Q92973 Q92973-2 TNPO1 Transportin-1 0 9625100.0 4810700.0 1680300.0 3134100.0 False True 4000310.200145132 1671247.8903865623 3789425.819558883 1.0 0.417779573775536 0.9472829930592388 21.931680446038975 -10.527597984692742 9.163805534654987 1.0000148833513365 0.6825312834173888 0.32400239894516314 0.21616886571734176 6.573432713535916e-05 3.3888207418481055e-06 0.2093143958656296 0.06976820140765096 2.967577128835306e-11 10.527597984692742 -0.3174835999339477 ATVGILITTIASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATVGILITTIASK 13 0 Q92973-2;Q92973 Q92973-2 TNPO1 Transportin-1 0 46939000.0 14242000.0 19979000.0 12718000.0 False True 18436549.75179064 18867151.08704754 10403454.497699913 1.0 1.0233558524265138 0.5642842417784534 24.13606535676208 -6.894914814985072 0.9928366765671297 1.0218395376423555 0.5207751716703894 0.9838626868361111 0.026819000219382487 0.1152465951523231 0.19927028508827183 0.02043721054005139 0.05194048453553156 1.27375289772735e-07 6.894914814985072 -0.501064365971966 ATVLLSMSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATVLLSMSK 9 0 Q53EL6;Q53EL6-2 Q53EL6 PDCD4 Programmed cell death protein 4 0 19328500.0 5228000.0 5825300.0 8275200.0 False True 6853958.628024024 4956187.946841547 7418961.6853235345 1.0 0.7231131986377924 1.0824345590575004 22.708506052788394 -6.700915700427839 1.8278507966166726 0.8282173292662006 1.0813758363372192 0.4218380248786152 0.116857924552127 0.3936068250874113 2.5573483840545923 0.05099418867732407 0.13098354310703164 1.9910597799982105e-07 6.700915700427839 0.2531585070710186 ATVLLSMSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATVLLSMSK 9 0 Q53EL6;Q53EL6-2 Q53EL6 PDCD4 Programmed cell death protein 4 0 10983300.0 4079600.0 2575500.0 4328200.0 False True 3950095.331060139 3603910.581055071 3194514.5767832473 1.0 0.9123604062709652 0.8087183495710453 21.913456040838746 -6.968908714607936 0.2830793755000648 1.0220026870053889 0.6959046958342052 0.999972551271058 0.0004095638935997546 0.07665877465377624 0.010293868825194116 0.0018810640677927642 0.009476596607180235 1.0742151804616521e-07 6.968908714607936 -0.32609799117118365 ATVLLSMSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATVLLSMSK 9 0 Q53EL6;Q53EL6-2 Q53EL6 PDCD4 Programmed cell death protein 4 0 20311800.0 5228000.0 5379500.0 9704300.0 False True 7160932.881387713 5141815.90237241 7412344.206332108 1.0 0.7180371590602005 1.0351087391976328 22.771716114311285 -6.672056344061227 1.9295981614723041 0.8203523461056509 1.033854350413282 0.288454346475882 0.11971350943538418 0.456377912978661 3.2777952681794393 0.049905864978700566 0.13300300904324 2.1278629655262764e-07 6.672056344061227 0.2135020043076311 ATVLLSMSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATVLLSMSK 9 0 Q53EL6;Q53EL6-2 Q53EL6 PDCD4 Programmed cell death protein 4 0 9814400.0 4079600.0 2375600.0 3359200.0 False True 3392368.1569235404 2362802.1712803203 4061593.1888140775 1.0 0.6965052323280533 1.1972737040715067 21.693861316273022 -6.742630892832707 1.6769608936950369 0.8199745764440473 1.1977448101739845 0.6167279661820941 0.1275109430448381 0.31308208236695984 1.7297205707509078 0.06012736092615159 0.1471290908394105 1.8087106973694097e-07 6.742630892832707 0.37777023372993723 ATVLLSMSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATVLLSMSK 9 0 Q53EL6;Q53EL6-2 Q53EL6 PDCD4 Programmed cell death protein 4 0 35412400.0 6985300.0 18558000.0 9869100.0 False True 9042608.55084843 17525230.986206923 8073025.0655173855 1.0 1.938072502824708 0.8927761298215134 23.108307580958968 -6.670137145186051 1.9365634669554765 1.5986781682784914 0.8969660092015497 0.27982834581792704 0.39845647368688364 0.4607802106066147 3.331564468004812 0.16562365703315832 0.4424779123641989 2.1372870523344443e-07 6.670137145186051 -0.7017121590769417 ATVMDVK(ub)PVDYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATVMDVKPVDYR 12 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 8570200.0 2569400.0 2143200.0 3857600.0 True False 3368508.2821049923 1823442.9141281662 3458452.5567121115 1.0 0.5413205969583339 1.0267015150548815 21.683678415788187 -11.034152941834737 13.256454323172349 1.6126020352487753 0.7840110560059178 0.20887310768535272 0.19815593003669588 0.040424117954554875 0.00010414580992328348 0.0021618202422011607 0.06395455141536377 9.243725880929436e-12 11.034152941834737 -0.8285909792428575 ATVMDVK(ub)PVDYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATVMDVKPVDYR 12 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 9394900.0 2569400.0 2035600.0 4789900.0 True False 3519376.61542417 1945660.4611709737 3658624.271087061 1.0 0.5528423564115983 1.0395660001412235 21.746888477311078 -6.6651845240730285 1.9550841695549437 0.713400963418257 1.0375370456666988 0.2576943221924757 0.19015730040289264 0.47222538405502135 3.475275348964628 0.0784451771900833 0.21086168607586064 2.1617998179184807e-07 6.6651845240730285 0.3241360822484418 ATVNTFGYIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATVNTFGYIAK 11 0 O75533;H7C341 O75533 SF3B1 Splicing factor 3B subunit 1 0 8852700.0 2439600.0 2375300.0 4037800.0 False True 3198339.225120006 2020914.498846884 3620007.189312569 1.0 0.6318637131966689 1.131839662560103 21.608891532671485 -6.709395919609133 1.7971820216173704 0.7735402464652543 1.1306529952457234 0.46229800857601244 0.15514525045069702 0.3762989591382172 2.3687899791887395 0.06870530350116974 0.17468325790823871 1.9525586163738214e-07 6.709395919609133 0.35711274878046906 ATVNTFGYIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATVNTFGYIAK 11 0 O75533;H7C341 O75533 SF3B1 Splicing factor 3B subunit 1 0 7218300.0 2439600.0 2102500.0 2676200.0 False True 3341586.0477110646 2009604.5979622586 2044136.6780691005 1.0 0.6013924433694614 0.6117264822401635 21.672101594194377 -10.049502980460908 5.208553041924315 1.0000044072220358 0.6065594628038399 0.9994828465868995 0.004218853705946404 2.1591472119010395e-07 3.940179590275296e-08 0.004084933266364162 0.0013616291781125619 8.922714961173495e-11 10.049502980460908 -0.3934449444181959 ATVPK(ub)TEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATVPKTEIR 9 1 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4 E7ETK0 RPS24 40S ribosomal protein S24 1 16870900.0 2929000.0 3433900.0 10508000.0 True False 4443507.13858272 2821093.7158168387 8431089.194179991 1.0 0.6348799783219525 1.8973952176138802 22.08326737521525 -6.829343658802022 1.3308468264862274 0.8048163715710595 1.9309150552665322 0.904560119978485 0.16387959843730152 0.181617811478893 0.6293414710333116 0.09669134522202269 0.2225195205069635 1.4813454272222262e-07 6.829343658802022 1.1260986836954727 ATVPLQSNVIEAAPDMK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATVPLQSNVIEAAPDMKR 18 1 O75165;H0Y8Q2 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 40566000.0 11967000.0 13711000.0 14888000.0 True False 15688852.888592867 11665372.2450594 13347532.575780258 1.0 0.7435452628624697 0.8507653600018807 23.90323653580128 -10.189515980916076 4.8160034969101435 1.0000253436655058 0.7971553114314895 0.8267541742289248 0.04377242136289667 1.1912806235406233e-05 2.004772270816025e-06 0.04238775707443157 0.014127488246470062 6.463742086592476e-11 10.189515980916076 -0.20287003223401623 ATVPLQSNVIEAAPDMK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATVPLQSNVIEAAPDMKR 18 1 O75165;H0Y8Q2 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 52911000.0 15292000.0 14945000.0 22674000.0 True False 14806563.830417605 20912616.437145405 16734999.194580501 1.0 1.4123882270499477 1.1302419242066988 23.81973353643864 -10.17196262481008 4.162517901555548 0.9999040847777637 1.2713150756583136 0.5521576073155785 0.11518574589900436 40375255.660243526 6.913423304933064 37535.2033726787 0.039431144567417885 6.730345748481764e-11 10.17196262481008 0.2714109908805499 ATVPLQSNVIEAAPDMK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATVPLQSNVIEAAPDMKR 18 1 O75165;H0Y8Q2 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 42617000.0 11967000.0 15781000.0 14869000.0 True False 16391523.296015069 15083743.239211624 11357248.436667481 1.0 0.9202160755174367 0.6928732755075017 23.966446597324172 -6.9526017697000215 0.5295098244771153 1.003598201481524 0.5991793147641475 0.999389964926038 0.0032137732075105236 0.08245750772552754 0.03176640886622513 0.0035880400437781367 0.018798854689501633 1.1153167647631635e-07 6.9526017697000215 -0.40441888671737636 ATVPLQSNVIEAAPDMK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATVPLQSNVIEAAPDMKR 18 1 O75165;H0Y8Q2 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 55724000.0 15292000.0 25172000.0 15260000.0 True False 12715975.550464455 25036393.43974923 18450795.445731975 1.0 1.968892857680492 1.4509933093617857 23.600138811872917 -10.21763572686998 4.852069999811835 0.9998864630263263 1.709943083522599 0.7147341442333092 0.2114316052381548 0.00025971942521044227 4.187832292723364e-05 0.20475017426391798 0.06823925716172248 6.05848829444928e-11 10.21763572686998 0.7100566204962727 ATVPLQSNVIEAAPDMK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATVPLQSNVIEAAPDMKR 18 1 O75165;H0Y8Q2 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 51693000.0 28933000.0 12449000.0 10311000.0 True False 37454338.85469452 11756202.206449503 8434503.79979428 1.0 0.3138809164956327 0.2251943047911284 25.15862951992003 -13.999999999999998 0.2884279465672595 6.860218266802587 0.20064182247686843 0.9996239453320572 0.006714357328630513 15.872869474485432 0.17027665866040928 55.14231589983041 0.033734139601010904 1.0000000000000041e-14 13.999999999999998 -6.659576444325719 ATVQAPGPPGLLDGTADDATTVDTLLASK(ub)SSCAGLLCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATVQAPGPPGLLDGTADDATTVDTLLASKSSCAGLLCR 38 1 Q6PJG6 Q6PJG6 BRAT1 BRCA1-associated ATM activator 1 1 200144000.0 10541000.0 40093000.0 149510000.0 True False 15991467.650324484 32938090.901961185 119959282.96743916 1.0 2.059729076917642 7.501455500552825 23.930799015454973 -6.939212579823797 0.6668487449495177 0.9380098222232981 8.93553688616423 0.9980589353569005 0.1254795843234507 0.08812770740552311 0.056259356688851424 0.12142820540904271 0.47000680823439245 1.1502372294039906e-07 6.939212579823797 7.997527063940932 ATVQAPGPPGLLDGTADDATTVDTLLASK(ub)SSCAGLLCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATVQAPGPPGLLDGTADDATTVDTLLASKSSCAGLLCR 38 1 Q6PJG6 Q6PJG6 BRAT1 BRCA1-associated ATM activator 1 1 150777000.0 10541000.0 15916000.0 124320000.0 True False 13645532.294173922 15030260.60871155 101695035.63092095 1.0 1.1014785121375477 7.452625037891744 23.701925337547422 -6.910373078871712 0.8931966110739759 0.8056688955503336 8.279970265407247 0.9910614547342339 0.28534876924824193 0.10417165950895535 0.13743520850138677 0.23405068694692716 0.6477627910177155 1.2292123673467292e-07 6.910373078871712 7.474301369856914 up ATVVESSEK(ub)AYSEAHEISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATVVESSEKAYSEAHEISK 19 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 100198000.0 42791000.0 41504000.0 15903000.0 True False 56099415.38863351 35311764.98132492 14257510.112347754 1.0 0.6294497854692359 0.2541472137201008 25.74148240081541 -7.504386238860214 0.32364651940473504 1.0729226766386808 8.92015671982055e-14 0.9995779797445674 0.006255281995474231 0.12271256617557894 0.03506812893561029 0.021632904553874087 0.06553665454166882 3.1305003821713246e-08 7.504386238860214 -1.0729226766385915 down ATVVESSEK(ub)AYSEAHEISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATVVESSEKAYSEAHEISK 19 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 118678000.0 57832000.0 35663000.0 25183000.0 True False 55996154.81563632 49903421.880088106 18586816.82619391 1.0 0.8911937265048262 0.33193023498470187 25.738824426758995 -6.939191012494783 0.6670462726016061 1.0063737197021543 0.1846369206957063 0.998056020513943 0.012904241552136257 0.08813762461619579 0.05630473513343511 0.012485623148806777 0.04830878869362529 1.1502943523051413e-07 6.939191012494783 -0.8217367990064479 down ATVVESSEK(ub)AYSEAHEISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATVVESSEKAYSEAHEISK 19 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 179429000.0 60910000.0 73454000.0 45065000.0 True False 92404923.11747144 60345559.80127856 36157882.99730882 1.0 0.6530556789118602 0.3912982314951169 26.461466381306924 -7.732766914623932 0.1906021217997582 1.238042676562312 1.358711827893301e-12 0.9999224586271322 0.002195367460998623 0.13058936991547204 0.02474699310415129 0.05294191571717702 0.08595343516828353 1.8502613858191e-08 7.732766914623932 -1.2380426765609533 down ATVVESSEK(ub)AYSEAHEISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATVVESSEKAYSEAHEISK 19 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 97456000.0 42791000.0 27709000.0 26956000.0 True False 58611989.08329411 26484724.758590408 20589547.97624646 1.0 0.45186531241846595 0.351285603820516 25.804692462338302 -13.999999999999998 0.23845963225565445 4.601237367545464 0.3061595754342861 0.9995224412934569 0.006229725491895444 13.569543895167508 0.15456332220233676 23.24912144682038 0.049595852979714444 1.0000000000000041e-14 13.999999999999998 -4.295077792111178 ATVVESSEK(ub)AYSEAHEISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATVVESSEKAYSEAHEISK 19 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 120175200.0 57832000.0 45591000.0 16752200.0 True False 48089870.391999744 45345392.23389508 20255007.56657868 1.0 0.9429302234392954 0.4211907289720688 25.51922970219327 -6.927701684994987 0.7654230134874489 1.0086471712410088 0.3200910976685603 0.9960669271701552 0.016333667722213747 0.09384891596559401 0.08365643246539593 0.014682163383825825 0.04781892757091011 1.1811316713181356e-07 6.927701684994987 -0.6885560735724485 down ATVVESSEK(ub)AYSEAHEISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ATVVESSEKAYSEAHEISK 19 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 186460000.0 60910000.0 77609000.0 47941000.0 True False 78849195.7155996 73289990.92620611 39216229.9162 1.0 0.9294957324682812 0.49735738659464124 26.232592703399373 -6.9353850746299965 0.7011778968272888 1.0054468543275958 0.3951083827692728 0.9974948541046229 0.011121532406958352 0.08993635384820294 0.06467725775278318 0.01047921786764304 0.03801026348908492 1.1604192519810377e-07 6.9353850746299965 -0.6103384715583231 down ATVWEGSNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATVWEGSNR 9 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 7824100.0 2704400.0 712000.0 4407700.0 False True 2618550.3023137185 996305.3130309498 3253191.1418343675 1.0 0.38047973038769844 1.2423634325297812 21.32033688852866 -6.713771623483367 1.781620296666136 0.6206241536863285 1.2405896899592364 0.4831440234522534 0.26091193587555106 0.3675004236166618 2.2761236958794138 0.11643771388816909 0.2944770258243486 1.9329845220146505e-07 6.713771623483367 0.6199655362729078 ATWK(ub)SNYFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ATWKSNYFLK 10 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VYN4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 10777600.0 3438400.0 4535500.0 2803700.0 True False 3329249.874085002 6346548.802320041 2069326.860802917 1.0 1.9062999301199346 0.6215594920977936 21.666765724144412 -6.717127254627334 1.7693882874995956 1.553049306317191 0.6238384462706641 0.4990845916542328 0.3815132619770432 0.36090902823538235 2.2065645235847158 0.17130020033753873 0.43153030692133776 1.9181066250595903e-07 6.717127254627334 -0.929210860046527 ATWK(ub)SNYFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ATWKSNYFLK 10 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VYN4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 11867700.0 3416000.0 4686100.0 3765600.0 True False 4678987.513928928 4479052.607139575 2876242.8349663764 1.0 0.9572696216448185 0.6147147916945831 22.157764948136343 -6.930057289280118 0.7463236972988638 1.0051982401644908 0.5442878377617654 0.9965494329950988 0.01012928142682699 0.09260823534418666 0.07753515321252827 0.009231382188595073 0.030985588930745697 1.1747425803804433e-07 6.930057289280118 -0.4609104024027254 ATWK(ub)SNYFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATWKSNYFLK 10 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VYN4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 11575100.0 3438400.0 6613100.0 1523600.0 True False 2859181.946947224 6577473.917702431 1842177.7156695444 1.0 2.3004740655715397 0.6443023738438385 21.447170999578688 -6.697289123905473 1.8403114721517144 1.8096909625067927 0.64944585353948 0.40472446159957853 0.549226557826002 0.40124403580533924 2.6399289387927585 0.23825098752762724 0.6148287473518274 2.0077557395550794e-07 6.697289123905473 -1.1602451089673127 ATWYTLTVPGDSPCAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ATWYTLTVPGDSPCAR 16 0 Q7Z6M1;Q7Z6M1-2;Q5T1S4 Q7Z6M1 RABEPK Rab9 effector protein with kelch motifs 0 4101970.0 834270.0 1400500.0 1867200.0 False True 1093736.0490821719 1191550.8591062434 1674000.0554471316 1.0 1.0894318241646643 1.530533858559292 20.060833184396383 -6.940110350054899 0.6585400842808143 0.9950580159366397 1.6498706070071 0.998178271590587 0.009898262653465504 0.08771638791047758 0.05438149706534379 0.00964327079983645 0.037946360245754984 1.1478619237541518e-07 6.940110350054899 0.6548125910704604 ATYINLK(ub)PAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ATYINLKPAR 10 1 Q9H467 Q9H467 CUEDC2 CUE domain-containing protein 2 1 9551400.0 2624500.0 3119600.0 3807300.0 True False 3981558.376650857 2562883.006453953 3054785.4862011303 1.0 0.6436884164460644 0.7672336299563955 21.924901779546662 -10.358959708004871 5.0696252607991426 1.0001656947378605 0.705461023201192 0.8834269370958592 0.05043712221071783 9.451030717971053e-05 1.1950518562181911e-05 0.048862821793832084 0.016278511196042567 4.375626984815494e-11 10.358959708004871 -0.29470467153666857 ATYINLK(ub)PAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ATYINLKPAR 10 1 Q9H467 Q9H467 CUEDC2 CUE domain-containing protein 2 1 15239900.0 5512800.0 6261900.0 3465200.0 True False 4584137.458448889 6228165.901810161 4189757.298725456 1.0 1.3586341941669335 0.9139685135321232 22.128218874249985 -6.6920788748997495 1.858952485978295 1.22440639801599 0.9154651491689361 0.38012129640619474 0.1516146242434202 0.41226440229900563 2.763743569024009 0.06520587392586466 0.16936181784526458 2.0319879355591686e-07 6.6920788748997495 -0.308941248847054 AVAALLTIPEAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVAALLTIPEAEK 13 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 8970700.0 3102800.0 3303300.0 2564600.0 False True 4067800.8475579373 2810460.5161625477 2299239.793380308 1.0 0.6909041571810919 0.5652291937449773 21.95581761841298 -13.999999999999998 0.12385448035589497 2.4700165282405737 0.3746792252284047 0.9996742572175447 0.0032971339692528844 11.950611171433566 0.10878739617899692 4.303564587979268 0.16917256363874397 1.0000000000000041e-14 13.999999999999998 -2.095337303012169 AVAALLTIPEAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVAALLTIPEAEK 13 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 6142850.0 1431900.0 915250.0 3795700.0 False True 1386445.1182824324 1280714.0979656957 2801492.3014408248 1.0 0.9237394838623548 2.020629785123693 20.40295907848999 -6.890226348192793 1.0210152507550134 0.94138240227234 2.1154017044736255 0.9810437405771625 0.06885110192954644 0.11896077695613415 0.22076302624734132 0.051364691815567326 0.12816118293057716 1.2875783090313944e-07 6.890226348192793 1.1740193022012855 up AVAALLTIPEAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVAALLTIPEAEK 13 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 12167200.0 3102800.0 5154100.0 3910300.0 False True 4249989.010017167 4926374.81967053 2986767.675156419 1.0 1.159150013813949 0.702770682022153 22.01902767993587 -6.812499221069687 1.4039248063751266 1.0864842232810632 0.6943163665605175 0.8662620448321021 0.06916787044468814 0.20341832710026178 0.7897154045107883 0.038733196904334126 0.08950397450583758 1.5399292880023138e-07 6.812499221069687 -0.39216785672054566 AVAATSTK(ub)GQEQSAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVAATSTKGQEQSAQK 16 1 Q9Y6Y8;Q9Y6Y8-2 Q9Y6Y8 SEC23IP SEC23-interacting protein 1 2710430.0 856010.0 1115600.0 738820.0 True False 1122237.3996126328 949156.8285747397 662373.9936618721 1.0 0.8457718740280479 0.5902262693174425 20.09794646720969 -6.963551045519253 0.3821058772472568 1.0171431541184988 0.40978797196091227 0.999880088260897 0.0018504516671751998 0.07845616788337707 0.016615334716391015 0.003318826561329204 0.021571846507089806 1.0875493032148778e-07 6.963551045519253 -0.6073551821575864 AVAATSTK(ub)GQEQSAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVAATSTKGQEQSAQK 16 1 Q9Y6Y8;Q9Y6Y8-2 Q9Y6Y8 SEC23IP SEC23-interacting protein 1 3407900.0 1102100.0 1039100.0 1266700.0 True False 1067114.43875904 1454018.0488349167 934913.2698145509 1.0 1.362569932542391 0.8761134100123061 20.025283470300995 -6.707225861214329 1.8058297127379905 1.2235386689972656 0.8773830058358632 0.45160815560390233 0.15285359599788806 0.3806643845723189 2.418205347639585 0.06741506495714869 0.1717973427625602 1.9623394679973177e-07 6.707225861214329 -0.34615566316140245 AVAATSTK(ub)GQEQSAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVAATSTKGQEQSAQK 16 1 Q9Y6Y8;Q9Y6Y8-2 Q9Y6Y8 SEC23IP SEC23-interacting protein 1 2500540.0 856010.0 919730.0 724800.0 True False 1172500.0298004393 879093.2874596099 553617.1677245661 1.0 0.7497597143850244 0.47216814810554186 20.161156528732583 -6.969787161625528 0.26322082171216943 1.0749323809670777 0.13872494045352526 0.9999806738593522 0.0009477171657365612 0.07637183517754531 0.009277007751357726 0.005676459328593612 0.026066731490458125 1.0720445624755636e-07 6.969787161625528 -0.9362074405135524 down AVAELK(ub)AR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVAELKAR 8 1 P41250 P41250 GARS Glycine--tRNA ligase 1 6634800.0 2485600.0 2534000.0 1615200.0 True False 3258645.670584641 2155937.077454639 1448074.5980924387 1.0 0.6616052481299195 0.44437927423776524 21.635841058227438 -8.5830521544711 0.1381247819143402 1.4632965888898541 1.8894201513719654e-15 0.9999208374321911 0.002034119062722382 0.19223854547192368 0.03570152253552931 0.18879446326481145 0.15681393236158528 2.6118476784959257e-09 8.5830521544711 -1.4632965888898521 AVAELK(ub)AR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVAELKAR 8 1 P41250 P41250 GARS Glycine--tRNA ligase 1 10045900.0 4088600.0 3790900.0 2166400.0 True False 3958809.6309864894 5304626.139282337 1598954.8493931035 1.0 1.3399548434362292 0.4038978881120542 21.916635262851543 -6.808429181623783 1.4210118421869384 1.185619584829853 0.388085484976129 0.855719019539634 0.14695513313696287 0.20894723198610254 0.8318449238010301 0.08132139754710654 0.1882604974999691 1.5544287435538537e-07 6.808429181623783 -0.7975340998537239 down AVAELK(ub)AR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVAELKAR 8 1 P41250 P41250 GARS Glycine--tRNA ligase 1 8858700.0 2462100.0 2693100.0 3703500.0 True False 3735185.703620523 2212495.2637136597 2971501.601698282 1.0 0.5923387588384383 0.7955432038674809 21.83274854112913 -10.125037424422256 5.202751052359357 1.0000085820820666 0.693940981352645 0.7515344407011221 0.08295786729886291 8.258437040622221e-06 1.3888004143102342e-06 0.08032586079078849 0.02677453654029034 7.498295915453368e-11 10.125037424422256 -0.3060676007294215 AVAELK(ub)AR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVAELKAR 8 1 P41250 P41250 GARS Glycine--tRNA ligase 1 6316800.0 2485600.0 1865200.0 1966000.0 True False 3404593.4908143245 1782789.2966084222 1501671.2910409742 1.0 0.5236423383344975 0.44107212655270583 21.69905111975033 -13.999999999999998 0.2465403171638661 4.255947603268821 0.40676194877380123 0.9995363074245823 0.0053044883062154935 13.863488668830568 0.15712630442059172 22.30849424932542 0.0388528377633389 1.0000000000000041e-14 13.999999999999998 -3.8491856544950194 AVAELK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVAELKAR 8 1 P41250 P41250 GARS Glycine--tRNA ligase 1 10100600.0 4088600.0 4178700.0 1833300.0 True False 3399852.0556911426 4156188.5136929913 2216634.553778534 1.0 1.222461579390135 0.651979708960578 21.69704053828582 -6.800957560967248 1.4520868667164049 1.1225932662326983 0.6439251068959125 0.8349230221894879 0.09538667738964816 0.21939493052297188 0.9132112438475048 0.05167612947835759 0.12010552414552186 1.5814025655631262e-07 6.800957560967248 -0.47866815933678575 AVAELK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVAELKAR 8 1 P41250 P41250 GARS Glycine--tRNA ligase 1 7892200.0 2462100.0 1943600.0 3486500.0 True False 3187236.985246716 1835436.9514382894 2851992.7745109834 1.0 0.5758708749723588 0.8948166665084736 21.60387486322158 -9.901418202644578 7.030363052087976 1.0000000050032622 0.7353437707404151 0.47863881796749086 0.1302090741452671 1.015087295755975e-08 1.8705412828392035e-09 0.12607439580107863 0.04202479797414151 1.2548210553401556e-10 9.901418202644578 -0.2646562342628471 AVAFQNPQTHVIENLHAAAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVAFQNPQTHVIENLHAAAYR 21 0 P22695;H3BRG4;H3BSJ9;H3BP04 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 17843200.0 4128300.0 6291100.0 7423800.0 False True 5654644.07311264 6013138.400114326 5670451.337960315 1.0 1.0633982125782764 1.002795448244539 22.431004787152762 -6.635596727266869 2.0600366524326112 1.0415959444127143 1.0030433794472071 0.13802197500599156 0.027156123441887964 0.5445929437602494 4.411297307372696 0.01075454913069929 0.03007835019526566 2.3142127007658498e-07 6.635596727266869 -0.038552564965507186 AVAHHTTAAFIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVAHHTTAAFIR 12 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 21452300.0 7589700.0 9275200.0 4587400.0 False True 9950170.198759349 7891376.314446422 4112739.853448027 1.0 0.7930895810636857 0.4133336185506485 23.24628977264941 -6.961689835215711 0.4109309551344239 1.0185182162856379 0.17379060721055486 0.9998278157819658 0.0031879048809901607 0.07910299113087361 0.018941461816367477 0.004891365850966467 0.03169726744786541 1.0922201006040175e-07 6.961689835215711 -0.844727609075083 down AVAHHTTAAFIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVAHHTTAAFIR 12 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 13932100.0 4483800.0 2622500.0 6825800.0 False True 4341464.223308028 3669677.926156832 5037918.210389334 1.0 0.8452627356584962 1.1604191469187406 22.049750264399776 -6.773237647626728 1.5624357109754354 0.9116126261683319 1.1623966238937646 0.7426495441192983 0.0652734423137539 0.261231284932259 1.2590432306221027 0.0329233092596633 0.07812868288474077 1.6856303894828836e-07 6.773237647626728 0.2507839977254327 AVAHHTTAAFIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVAHHTTAAFIR 12 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 18539700.0 7589700.0 5296300.0 5653700.0 False True 10395817.193930427 5062291.953478011 4318412.501606483 1.0 0.48695469139584513 0.4153990418500027 23.3094998341723 -13.999999999999998 0.27752485585979064 5.124809384145939 0.39332702176138895 0.9995997138760437 0.005209093060284391 15.265997302292318 0.1668472342995774 35.687299190554825 0.02864229537047291 1.0000000000000041e-14 13.999999999999998 -4.73148236238455 AVAHHTTAAFIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVAHHTTAAFIR 12 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 12618600.0 4483800.0 4486500.0 3648300.0 False True 3728478.366019647 4462330.3339994745 4411142.66216671 1.0 1.1968234480500028 1.1830946110264935 21.830155539834053 -10.060404389279434 4.587658000216791 0.9999907078412654 1.1899590295462674 0.9960977838950441 0.005604774272268362 5.326987550366828e-07 1.0911159357021658e-07 0.005427064783397059 0.0018089331141218034 8.701529777416864e-11 10.060404389279434 0.189968321705002 AVAIDLPGLGHSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVAIDLPGLGHSK 13 0 Q96IU4;B4DQI4 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 7313800.0 2080700.0 2569200.0 2663900.0 False True 2727817.8495274656 2185885.3746631606 2388265.1819331674 1.0 0.8013311354501977 0.8755222356019415 21.379315880710795 -10.877833010971182 10.168363772263103 1.009249776851991 0.8384266860492176 0.8634578395640932 0.030288389804582653 0.00641503655460077 7.707278164782762e-05 0.029621045731190395 0.009775535774715603 1.324850850966221e-11 10.877833010971182 -0.17082309080277347 AVAIDLPGLGHSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVAIDLPGLGHSK 13 0 Q96IU4;B4DQI4 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 8733300.0 3511000.0 1460000.0 3762300.0 False True 3399545.226824239 2042985.613799418 2776840.763419346 1.0 0.6009585040019952 0.8168271277900879 21.696910332484748 -10.071148902844595 5.087660260182927 1.0000054748737484 0.7088928158950499 0.7080072020026198 0.08812799662972456 5.472881071952714e-06 9.992189657263985e-07 0.08533117012439881 0.02844318860630077 8.488893736766917e-11 10.071148902844595 -0.2911126589786984 AVAIDLPGLGHSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVAIDLPGLGHSK 13 0 Q96IU4;B4DQI4 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 11366300.0 2080700.0 4192300.0 5093300.0 False True 2849991.018803255 4007070.323917809 3890367.439806201 1.0 1.4059940180444586 1.3650455086135016 21.442525942233686 -10.358121729721802 5.270836000265448 0.9998404813182896 1.3855197633289968 0.991609556435799 0.01671715897229011 3.134969858417019e-05 3.817720333665481e-06 0.01619295575303816 0.005395439857956681 4.384077978961424e-11 10.358121729721802 0.3856792820107072 AVAIDLPGLGHSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVAIDLPGLGHSK 13 0 Q96IU4;B4DQI4 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 5693900.0 3511000.0 1017400.0 1165500.0 False True 2919552.063672557 1011919.0642619109 1409200.6613368664 1.0 0.3466007942975333 0.48267701024115583 21.477315607919024 -9.89872493657725 6.825455003311897 1.0000000178123183 0.4146389022719089 0.9610485757562002 0.05555288253180157 1.5101217274647542e-08 2.466039680153631e-09 0.053788848822887696 0.017929615739953143 1.262626974951642e-10 9.89872493657725 -0.5853611155404094 AVAILCNHQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVAILCNHQR 10 0 P11387 P11387 TOP1 DNA topoisomerase 1 0 2431390.0 388100.0 753090.0 1290200.0 False True 508802.8583657461 640731.9075218282 1156702.4804723056 1.0 1.259293058179415 2.273380468395139 18.956747249891045 -6.945391971667598 0.6073311853429277 0.9887370653568465 2.5965056207498862 0.9987882439161369 0.019126674166644327 0.08539056613336454 0.04403890048270583 0.019491260291902724 0.08543105084349462 1.133986875942887e-07 6.945391971667598 1.6077685553930396 up AVAK(ub)QQNVQSASQDEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVAKQQNVQSASQDEK 16 1 A0A087X256;Q2M389 A0A087X256 KIAA1033 WASH complex subunit 7 1 8316900.0 2368400.0 1701500.0 4247000.0 True False 3593035.953232955 1397854.031119821 3407578.5884737694 1.0 0.38904537814659346 0.9483842168090987 21.776771940871146 -10.60714114917696 9.446016919778145 1.0000644541203667 0.6687147974778487 0.31867459478597704 0.22834912467401025 0.0003100162261720574 1.2893600437704988e-05 0.22114067118587885 0.07369936308195689 2.470920945448268e-11 10.60714114917696 -0.33134965664251803 AVAK(ub)QQNVQSASQDEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVAKQQNVQSASQDEK 16 1 A0A087X256;Q2M389 A0A087X256 KIAA1033 WASH complex subunit 7 1 7547900.0 2368400.0 2377500.0 2802000.0 True False 3065940.4881435893 2245190.0350095336 2292064.750947879 1.0 0.7323005921647828 0.7475894459829232 21.547898262963596 -10.668594460574687 10.03390763678854 1.0001229624770913 0.739945019075237 0.9974144271160535 0.0062416484344077145 1.7176946540065304e-05 5.673303897974012e-07 0.006046258949017195 0.002014483369945225 2.1448925434177504e-11 10.668594460574687 -0.2601779434018543 AVANQTSATFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVANQTSATFLR 12 0 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 0 12112200.0 2531500.0 3714000.0 5866700.0 False True 3318821.0150808706 3159885.677058609 5259670.161360154 1.0 0.9521109040529597 1.5848007884305837 21.66223939590277 -6.88864529185783 1.030324705968564 0.9648927102472971 1.6378030079077772 0.9800183262414526 0.04065845636914531 0.12025081076642856 0.2283040637236814 0.03011897216399235 0.07473277530559362 1.2922743021642255e-07 6.88864529185783 0.6729102976604802 AVANQTSATFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVANQTSATFLR 12 0 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 0 7570190.0 2806500.0 785990.0 3977700.0 False True 2717409.193700434 1099839.9058837013 2935821.041557856 1.0 0.40473842085813855 1.0803750308800564 21.373800395565933 -6.6740670391519545 1.9227523557930706 0.6213847173287012 1.0777098638989975 0.29724329050252707 0.2526195937875789 0.4518634295812601 3.2243183959628334 0.10562205434025233 0.2807284457810295 2.118034163159954e-07 6.6740670391519545 0.4563251465702963 AVANQTSATFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVANQTSATFLR 12 0 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 0 5356800.0 2531500.0 2825300.0 0.0 False True 3467463.9612151817 2700468.9039822957 0.0 1.0 0.7788022987947392 0.0 21.72544945742566 -7.284781017075206 0.8286360279777658 0.9889897159944385 7.346667535198796e-18 0.9884441423165361 0.04610408097925561 0.10226206662713735 0.13756556657140379 0.039233218886248374 0.06931711488772636 5.1906169778406106e-08 7.284781017075206 -0.9889897159944385 down AVANYDSVEEGEK(ub)VVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVANYDSVEEGEKVVK 16 1 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ER27;A0A2R8YDT8;A0A2R8YF45 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 1 14003200.0 5418400.0 4156900.0 4427900.0 True False 7014225.612631826 3925564.8607912255 3622067.634090696 1.0 0.5596576268835334 0.5163888124111324 22.74185240496057 -13.999999999999998 0.3280254603054607 5.736810509798802 0.508547651629456 0.9997107283311575 0.0037161247642014113 18.6578458393321 0.18304149739601935 60.91019863567991 0.013968636618450783 1.0000000000000041e-14 13.999999999999998 -5.228262858169345 AVAQAGTVGTLLIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVAQAGTVGTLLIVK 15 0 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 9759700.0 2725700.0 4104400.0 2929600.0 False True 3573419.0957163484 3492039.5188258924 2626473.094707534 1.0 0.9772264112574957 0.7350028150507255 21.76887369451365 -6.925208997642385 0.7851190091379092 1.004409742182437 0.6908433295208605 0.9955099614840831 0.008035168593392625 0.09520292976782417 0.09043367385814166 0.007121564583967838 0.022521931813370154 1.187930416337699e-07 6.925208997642385 -0.3135664126615765 AVAQAGTVGTLLIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVAQAGTVGTLLIVK 15 0 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 6799500.0 2481500.0 1165200.0 3152800.0 False True 2402726.140804425 1630470.4364377295 2326987.098027405 1.0 0.6785918747659911 0.9684778712435106 21.19624079090111 -10.329245903001102 7.871881487464225 1.0000009258958062 0.8235348735112311 0.330694230238205 0.11834546249136073 1.9231080891677187e-06 1.6376848167698943e-07 0.11458810233769047 0.03819583377735456 4.685480092442658e-11 10.329245903001102 -0.17646605238457513 AVAQAGTVGTLLIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVAQAGTVGTLLIVK 15 0 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 9765700.0 2725700.0 3176500.0 3863500.0 False True 3733464.9492728533 3036151.7267191983 2951020.871280161 1.0 0.8132262571021412 0.7904241532667704 21.832083756036543 -13.999999999999998 0.2966371274770231 2.6711801474680423 0.7846158166087751 0.9996423149434773 0.0017755615347326405 16.372693094149867 0.17287799661414832 16.761579509508195 0.008361578884449035 1.0000000000000041e-14 13.999999999999998 -1.8865643308592672 AVAQALEVIPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVAQALEVIPR 11 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 12937900.0 4043600.0 2100200.0 6794100.0 False True 3915238.131354736 2938820.8123983135 5014521.391368939 1.0 0.7506110008643162 1.2807704724805162 21.90066862664296 -6.778784458185833 1.5404867166590654 0.8585637600143468 1.2848189318486893 0.7630767728973318 0.10541154553959309 0.2524833509846748 1.1833716888124883 0.053897892880148554 0.12731259014662033 1.6642384125686138e-07 6.778784458185833 0.4262551718343426 AVAQALEVIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVAQALEVIPR 11 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 19209500.0 2443300.0 8231100.0 8535100.0 False True 3346654.0376998032 7867422.785392236 6519285.165902254 1.0 2.350832412542891 1.9480009264366744 21.674287988621025 -10.063439371242472 4.87103019334152 0.9999684890236085 2.1494166695018704 0.9156504425405538 0.16445526558959964 5.627859364132154e-05 1.0820907235759916e-05 0.15923746919177828 0.053077708729442674 8.640932821696245e-11 10.063439371242472 1.149448180478262 AVASAAAALVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVASAAAALVLK 12 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 4622450.0 1602000.0 2135300.0 885150.0 False True 2100237.513790069 1816721.5633342091 793563.1689583473 1.0 0.8650076724207112 0.3778444884199266 21.00212105940167 -6.947241066721283 0.5883535441830472 1.005659079384225 0.21274892907282753 0.9989666081731614 0.008589959337213748 0.08461287227212015 0.04069572294875758 0.00892070659433092 0.040792173471833636 1.1291689653724559e-07 6.947241066721283 -0.7929101503113976 down AVASAAAALVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVASAAAALVLK 12 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 3880040.0 1325500.0 633440.0 1921100.0 False True 1283422.728042016 886375.8953459605 1417906.2782353635 1.0 0.6906344074942569 1.104785077632617 20.29156500647125 -6.706770604651003 1.8068921645590643 0.809179752256288 1.1037141125603964 0.4496348644712035 0.1304334020555064 0.381623573143595 2.4267328547487175 0.057491956127386605 0.14662179493555363 1.964397602206315e-07 6.706770604651003 0.2945343603041084 AVASAAAALVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVASAAAALVLK 12 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 17128900.0 1533000.0 10199000.0 5396900.0 False True 2325673.077312158 8378908.764849286 4330200.349454695 1.0 3.602788735264981 1.8619127476245383 21.14921687899466 -10.420655386412623 6.2715487503168665 0.9995970660434751 2.7323507414446793 0.5690224307479608 0.7107096458638004 0.004005002217054078 0.0003699699587347634 0.688278217070066 0.22938055186828896 3.796160916628835e-11 10.420655386412623 1.732753675401204 AVASAAAALVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVASAAAALVLK 12 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 6134800.0 1602000.0 1518100.0 3014700.0 False True 2194302.692422171 1451025.322314629 2302689.9496954377 1.0 0.6612694444233312 1.049394852245122 21.06533112092456 -6.676060036518966 1.915900157340761 0.784928782858378 1.0478754573829958 0.30619723829757195 0.14368714441397593 0.44732567967410625 3.1710893866941645 0.06025527046953016 0.1597250637381116 2.1083366750253184e-07 6.676060036518966 0.26294667452461784 AVASAAAALVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVASAAAALVLK 12 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 10033400.0 1533000.0 5991900.0 2508500.0 False True 1984498.7199476939 5658445.497696583 2051978.7393835676 1.0 2.8513223217628103 1.0340035590638488 20.92034320108711 -6.641814514063991 2.0374306872928414 2.2089375513968315 1.041497463945996 0.16182941224014502 0.7917555907634731 0.5287628902579926 4.197079465188813 0.316179608332917 0.8770026317901481 2.2813162076136307e-07 6.641814514063991 -1.1674400874508355 AVASLSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVASLSVK 8 0 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 0 10629600.0 2952000.0 3178800.0 4498800.0 False True 3870100.5872086645 2704535.430865354 4033307.331536823 1.0 0.6988282009527865 1.0421711892625178 21.883939633053355 -6.674991613846323 1.9195007650072504 0.8085954638647393 1.0408231743108844 0.30139795084699894 0.1277858474879025 0.44976971876428135 3.1993837003559915 0.05350274111492765 0.1420311927146939 2.1135298513499114e-07 6.674991613846323 0.2322277104461451 AVASLSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVASLSVK 8 0 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 0 8238800.0 2952000.0 2116800.0 3170000.0 False True 4043434.1748004034 2023272.7766784832 2421311.2881993353 1.0 0.5003847445540172 0.5988254497351522 21.947149694576247 -9.999983732444116 5.761743831219433 1.00000077939193 0.5496050971444291 0.9654111532172748 0.04018824960280648 4.0234993434102285e-07 6.984122805676282e-08 0.03891217261269235 0.012970701785327693 1.0000374581332156e-10 9.999983732444116 -0.45039568224750104 AVASLSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVASLSVK 8 0 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 0 5597700.0 1719300.0 2434500.0 1443900.0 False True 1429674.1279043627 2421384.865289585 1745812.8141607076 1.0 1.6936620856662536 1.2211263952294817 20.447254913787866 -10.185340941138536 4.111032059525488 0.9998082470020435 1.4573942403641977 0.5554082258013622 0.19291188814335938 45139328.78932296 33.586566468304284 87480.40362835342 0.06603887041532422 6.526180163392313e-11 10.185340941138536 0.4575859933621542 AVASLSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVASLSVK 8 0 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 0 10088000.0 2787200.0 4572000.0 2728800.0 False True 3608085.3439257722 4317564.1808889955 2232186.399852453 1.0 1.1966358246369184 0.6186623062035793 21.782802033139834 -6.814906984146739 1.3938690439913473 1.1065598813842155 0.6073807201517981 0.8722447787532089 0.08576114578809634 0.20018146662302658 0.7655612534156949 0.04836723131515263 0.11165250960902545 1.5314154203937707e-07 6.814906984146739 -0.49917916123241735 AVASQLDCNFLK(ub)VVSSSIVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVASQLDCNFLKVVSSSIVDK 21 1 A0A087X2I1;P62333;H0YJC0;H0YJS8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 100315870.0 31036700.0 51561000.0 17718170.0 True False 40689414.25983036 43868299.783203825 15884863.73308787 1.0 1.0781256152539835 0.39039303027691447 25.278150176608406 -6.8786523315211445 1.0872480217353937 1.0476138974221747 0.3428884986738408 0.972583777210988 0.050906221831968156 0.12883242403462836 0.27953456005032246 0.03610904607001805 0.08703254528631867 1.3223538027422188e-07 6.8786523315211445 -0.704725398748334 down AVASQLDCNFLK(ub)VVSSSIVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVASQLDCNFLKVVSSSIVDK 21 1 A0A087X2I1;P62333;H0YJC0;H0YJS8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 41078800.0 8568500.0 3476300.0 29034000.0 True False 8296497.657659771 4864404.718665011 21429124.39867033 1.0 0.5863202666216548 2.582912125441971 22.984071004784866 -6.852659108779148 1.2221491884857583 0.7786352403541064 2.666937089621998 0.9440931650267896 0.20344641472427302 0.1545540479829706 0.4428902420559547 0.13016354971565972 0.30177093200335087 1.403915248848464e-07 6.852659108779148 1.8883018492678918 up AVASQLDCNFLK(ub)VVSSSIVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVASQLDCNFLKVVSSSIVDK 21 1 A0A087X2I1;P62333;H0YJC0;H0YJS8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 382901000.0 18129000.0 181372000.0 183400000.0 True False 27503018.407431286 149004749.53409585 147150909.6129246 1.0 5.417759873724803 5.350354911341825 24.713086624756713 -10.189516579241692 4.222277978548742 0.9983439138769435 5.384057392843861 0.9998227380164253 0.02751796172479397 885409.6205513885 534346.0699005917 12624.820276128707 0.009420130131940162 6.463733181529284e-11 10.189516579241692 4.385713478966918 AVASQLDCNFLK(ub)VVSSSIVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVASQLDCNFLKVVSSSIVDK 21 1 A0A087X2I1;P62333;H0YJC0;H0YJS8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 178108200.0 31036700.0 54505400.0 92566100.0 True False 42511806.725280404 52097171.20274536 70703893.63867144 1.0 1.225475349457798 1.6631589924082457 25.341360238131298 -6.96062522288344 0.4265389952421554 0.981962676874649 1.9233603650440692 0.9997926693934825 0.003964253153804281 0.07947864741158907 0.02031237622253072 0.005689437866910691 0.03637141216006651 1.0949008101510932e-07 6.96062522288344 0.9413976881694202 AVASQLDCNFLK(ub)VVSSSIVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVASQLDCNFLKVVSSSIVDK 21 1 A0A087X2I1;P62333;H0YJC0;H0YJS8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 134452700.0 8568500.0 32828300.0 93055900.0 True False 7125087.398911499 32651447.431992605 112513458.44813174 1.0 4.58260307613641 15.791168886618912 22.764476280219142 -6.950503328558868 0.5532907134386734 0.8479274510710652 20.055386990119487 0.9992401902034288 0.17366594979499453 0.08328426827245895 0.03513083755476834 0.18770586509798187 0.9304374210969489 1.1207188365895238e-07 6.950503328558868 19.207459539048422 AVATYHANTER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVATYHANTER 11 0 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8Y4C5;A0A2R8YG32;A0A2R8Y7F3;A0A2R8YGP5 P51532 SMARCA4 Transcription activator BRG1 0 1775490.0 166700.0 823230.0 785560.0 False True 218545.3143250963 700407.2929254061 704277.786823612 1.0 3.204860717734345 3.2225709757197825 17.737572921092013 -10.605201073953076 0.8764544995825261 2.085916155428239e-10 3.2183501856008077 0.9999906517158514 0.00319073900858579 2.1819396100384436 0.48511949693250567 4.844348427630258 0.002447787582651573 2.481983705880573e-11 10.605201073953076 3.218350185392216 AVATYHANTER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVATYHANTER 11 0 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8Y4C5;A0A2R8YG32;A0A2R8Y7F3;A0A2R8YGP5 P51532 SMARCA4 Transcription activator BRG1 0 1859160.0 166700.0 848850.0 843610.0 False True 228333.49489811217 811345.0002284256 644366.6926933242 1.0 3.5533332531456545 2.8220419127769927 17.800782982614905 -9.863591613157162 5.5537492913034345 0.9999989317904834 3.187687582972646 0.9226749431016561 0.2985484395764347 3.9486658892836885e-06 8.081694341643031e-07 0.289068421393926 0.0963560945371852 1.369015568079121e-10 9.863591613157162 2.187688651182163 AVAVVVDPIQSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVAVVVDPIQSVK 13 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 6440500.0 6440500.0 0.0 0.0 False True 8443557.869890729 0.0 0.0 1.0 0.0 0.0 23.009419606131473 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 AVAVVVDPIQSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVAVVVDPIQSVK 13 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 14057200.0 4878500.0 2736200.0 6442500.0 False True 4723634.687855892 3828778.929094498 4755015.979142844 1.0 0.8105577975659294 1.0066434627909797 22.171465964542353 -11.12644204372375 10.106777552386285 2.73326437687479 0.9086006301779945 0.22461984646447675 0.08005163761259616 0.04020829398983514 0.0005030315258783986 0.0009968347965197393 0.025836554942518016 7.474083686284048e-12 11.12644204372375 -1.8246637466967957 AVAVVVDPIQSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVAVVVDPIQSVK 13 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 48370500.0 3708700.0 37493000.0 7168800.0 False True 5626369.042288067 30802081.215853915 5751883.537803338 1.0 5.474593114021486 1.0223082585894914 22.423772753689818 -6.645004210697024 2.026097119966921 3.9149334350786136 1.040857876075455 0.17412360614928069 1.9121631304827662 0.5209045740365481 4.092670615349592 0.7668797279309368 2.117978660370773 2.2646223508673402e-07 6.645004210697024 -2.874075559003159 AVAVVVDPIQSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVAVVVDPIQSVK 13 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 23063700.0 6440500.0 6106200.0 10517000.0 False True 8821726.897968167 5836407.893496864 8033101.204413992 1.0 0.6615947150711629 0.910604159177064 23.072629667654365 -9.763715959589451 6.3823054042204586 1.000000002753402 0.7860994371239783 0.49593081899033387 0.10165767986607473 3.980858067994765e-09 6.894291294409565e-10 0.09842962675034998 0.032809875094544784 1.722995092241255e-10 9.763715959589451 -0.2139005656294236 AVAVVVDPIQSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVAVVVDPIQSVK 13 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 10948600.0 4878500.0 3576100.0 2494000.0 False True 4056688.904194406 3556834.8394997283 3015483.8690468892 1.0 0.8767827465946787 0.7433362380657377 21.95187123997663 -6.970106140445473 0.2556390833281152 1.0395174077619682 0.5766647694955034 0.9999831955904199 0.00042961188515924136 0.07626827746690208 0.008906869148268007 0.0028661885823020035 0.012675059326477417 1.0712574606956755e-07 6.970106140445473 -0.46285263826646483 AVAVVVDPIQSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVAVVVDPIQSVK 13 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 18178000.0 3708700.0 9082800.0 5386500.0 False True 4800985.259406405 8577334.195577128 4406212.270157297 1.0 1.7865779068519017 0.9177725054507004 22.194899075782267 -6.6683107464027245 1.9436143838759088 1.50280064722616 0.9213267731007057 0.27151381820682974 0.3342523092166826 0.46498415296210344 3.384883636452418 0.13853791121944578 0.37092163141940937 2.146294208075451e-07 6.6683107464027245 -0.5814738741254543 AVAVVVDPIQSVK(ub)GK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVAVVVDPIQSVKGK 15 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 14705000.0 7999500.0 1172100.0 5533400.0 True False 7745560.251204911 1640125.642420753 4084036.5415582564 1.0 0.21175042078661935 0.5272745171561912 22.88493816500814 -10.516857937401246 6.2357144923102945 1.0006122665601853 0.369512468987051 0.8418687474553394 0.12881217294303293 0.001097421058860875 8.502794918067684e-05 0.12483326851432666 0.041573950049763 3.041879896001236e-11 10.516857937401246 -0.6310997975731343 AVAVVVDPIQSVK(ub)GK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVAVVVDPIQSVKGK 15 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 246932100.0 3026100.0 12020000.0 231886000.0 True False 4590814.937543592 9874937.08731135 186053630.46075562 1.0 2.151020509791042 40.527364529380776 22.13031884540203 -6.912893795966162 0.8761033617392027 1.4872132595724038e-14 45.800869717397795 0.9921444534164795 1.6279919233069482 0.10182109154826663 0.12783952389658546 1.3569278965095055 3.823691026326734 1.2220984802631288e-07 6.912893795966162 45.80086971739778 up AVAVVVDPIQSVK(ub)GK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVAVVVDPIQSVKGK 15 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 59977000.0 7999500.0 12409100.0 39568400.0 True False 6651938.687937503 12342249.715286497 47841969.496389344 1.0 1.855436481648229 7.192184375232599 22.665343440442417 -6.935014952946973 0.7044099566451155 0.9319408577396049 8.44223395845705 0.9974353561309119 0.1387469960733049 0.09011615692606162 0.06552744296506802 0.1304152436169033 0.47028339618581305 1.1614086253503128e-07 6.935014952946973 7.510293100717446 AVAVVVDPIQSVK(ub)GK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVAVVVDPIQSVKGK 15 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 21319900.0 3026100.0 6380800.0 11913000.0 True False 3917346.103348807 6025702.8708260115 9744956.237702379 1.0 1.5382104904325 2.487642393755238 21.90144516749448 -6.962423493756609 0.39981485958492363 0.9477018281713895 3.1128080675364904 0.999849790922311 0.007537588331821662 0.07884649807551 0.018013968473219902 0.01221664535843415 0.07955233290385459 1.0903765585303471e-07 6.962423493756609 2.165106239365101 AVAVVVDPIQSVKGK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVAVVVDPIQSVKGK 15 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 145821000.0 13483000.0 44628000.0 87710000.0 True False 17454009.289663885 42144412.56883508 71747679.98059899 1.0 2.414597807839637 4.11067043622392 24.057055134338967 -6.96871199407872 0.2872880117254291 0.657663281348643 5.919809342536331 0.9999705209734685 0.00690441113616915 0.07672288704771872 0.010518656736906329 0.030070682009754053 0.15429663703399776 1.07470187337448e-07 6.96871199407872 5.262146061187687 AVAYQMWQNLAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 AVAYQMWQNLAK 12 0 Q8WU39 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 148112200.0 50811300.0 58379000.0 38921900.0 False True 66614106.35732913 49669080.75955963 34894635.15322819 1.0 0.7456240648658774 0.5238325192872448 25.989324382300957 -6.972731943052733 0.18144033029649395 1.1682183142095708 0.0952320753090068 0.9999965944006438 0.00035897433986161923 0.07542589785918756 0.005731333303952361 0.008433029325287285 0.024781847440870287 1.0648000355035464e-07 6.972731943052733 -1.072986238900564 AVAYQMWQNLAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 AVAYQMWQNLAK 12 0 Q8WU39 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 136552800.0 43440300.0 19031200.0 74081300.0 False True 42061311.45451805 26630457.406396933 54677185.13863799 1.0 0.6331342624728454 1.2999400933506746 25.325990497624854 -6.7573508120903405 1.6226115996395793 0.7862020589761656 1.302048305891867 0.6799987628499917 0.15425083543728318 0.28738837890084484 1.49069627328313 0.07503084347869624 0.18077361445996434 1.7484337774925532e-07 6.7573508120903405 0.5158462469157015 AVAYQMWQNLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVAYQMWQNLAK 12 0 Q8WU39 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 132213000.0 17779000.0 97491000.0 16943000.0 False True 26972042.819003824 80092969.34934038 13594208.623619296 1.0 2.969481024733836 0.5040110871409843 24.684961457317744 -6.693975509694714 1.8526446055539114 2.230116730027174 0.5121786840670233 0.38899031162592446 0.8322912013756363 0.4081489245554683 2.7191429435719674 0.3590138941009955 0.9301173736056345 2.0231332619934053e-07 6.693975509694714 -1.7179380459601508 AVAYQMWQNLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AVAYQMWQNLAK 12 0 Q8WU39 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 170851500.0 50811300.0 56250900.0 63789300.0 False True 69597610.73375194 53765549.241148785 48723581.121871784 1.0 0.7725200430634142 0.7000754854683953 26.05253444382385 -13.999999999999998 0.16011350399662702 2.1205760049785813 0.6289480276743759 0.9995360675507057 0.0027522637350329573 12.01042366020733 0.12645441849738798 4.1795998752914985 0.06483543861444205 1.0000000000000041e-14 13.999999999999998 -1.4916279773042054 AVAYQMWQNLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVAYQMWQNLAK 12 0 Q8WU39 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 86639000.0 40289000.0 19786000.0 26564000.0 False True 33502088.605327096 19679408.89078648 32118409.581941277 1.0 0.5874084186995225 0.9586987235426927 24.997747703860153 -10.329398412972324 8.26474592425747 1.0000006509859567 0.7730535711211076 0.33250911956863083 0.15157863221803078 1.8182903777190136e-06 1.4739132383299756e-07 0.14676580161975564 0.04892179318511101 4.6838349944513934e-11 10.329398412972324 -0.22694707986484908 AVAYQMWQNLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVAYQMWQNLAK 12 0 Q8WU39 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 85921000.0 17779000.0 39920000.0 28222000.0 False True 23015265.976484057 37698416.90749975 23085885.582173813 1.0 1.6379744186323228 1.0030683810372607 24.456087779410193 -6.645095568152258 2.0263694024785357 1.4155861872954247 1.005744691257297 0.1742889246324203 0.27262721443661814 0.5206514955754363 4.092107915588265 0.10933545654003454 0.30186193348337836 2.264146018828467e-07 6.645095568152258 -0.4098414960381278 AVAYQMWQNLAK(ub)AETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVAYQMWQNLAKAETK 16 1 Q8WU39 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 1 30094100.0 14362000.0 8178700.0 7553400.0 True False 13906086.171361351 11444497.561357059 5574937.942857216 1.0 0.8229848010669049 0.4008991368353826 23.729213098780143 -6.95646804520663 0.48264951177899185 1.0098829016182724 0.1963243601013461 0.9996159225920513 0.004925152139521119 0.08098788601618193 0.025983637997619564 0.005983638770836156 0.034815639001911425 1.1054318025491604e-07 6.95646804520663 -0.8135585415169263 down AVAYQMWQNLAK(ub)AETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVAYQMWQNLAKAETK 16 1 Q8WU39 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 1 17640000.0 5437700.0 9350200.0 2852100.0 True False 7448164.638317125 8937077.247023407 2178492.72084332 1.0 1.199903289066217 0.29248718666019435 22.82845353269597 -6.848939705199477 1.2400893892938092 1.1065946637553605 0.25692750635309225 0.9387564927731811 0.09633993628697798 0.15863366965374498 0.46996001013300975 0.06080429574311411 0.14062189061009198 1.4159903537869463e-07 6.848939705199477 -0.8496671574022683 down AVCMLSNTTAIAEAWAR ddPTM_RPMI8226_Bortezomib_1h_R1 2 AVCMLSNTTAIAEAWAR 17 0 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2 P68363;P68366-2;Q71U36 TUBA1B;TUBA4A;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain 0 35710900.0 7975000.0 20587200.0 7148700.0 False True 10455302.230009861 17515670.008277055 6409021.099172511 1.0 1.6752906442055606 0.6129924279736929 23.317731430532554 -6.734980194308874 1.7053707510700886 1.4041212173402209 0.6130614458269047 0.5820791994561308 0.28378149445164813 0.3269718464971746 1.865148836441311 0.13176022580669897 0.32508956004102585 1.8408559504817602e-07 6.734980194308874 -0.7910597715133162 AVCMLSNTTAIAEAWAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVCMLSNTTAIAEAWAR 17 0 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2 P68363;P68366-2;Q71U36 TUBA1B;TUBA4A;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain 0 22880300.0 12001000.0 4806400.0 6072900.0 False True 11620034.82401528 6725620.585044877 4482225.30690518 1.0 0.5787952176481388 0.38573251929002017 23.470111056564896 -13.999999999998796 0.1048231259583265 3.053908862735648 0.0036310697168594006 0.9997693741697441 0.0038949080343537042 12.045564048307662 0.09735979247587569 5.291195604579463 0.33997107489432143 1.0000000000027732e-14 13.999999999998796 -3.0502777930187888 AVCMLSNTTAIAEAWAR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AVCMLSNTTAIAEAWAR 17 0 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2 P68363;P68366-2;Q71U36 TUBA1B;TUBA4A;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain 0 46086900.0 7975000.0 16740300.0 21371600.0 False True 10923573.016271418 16000658.193230757 16324068.241918271 1.0 1.464782463521475 1.494389081082027 23.380941492055445 -11.689879885530678 0.4431314643871458 2.1812684461161374e-10 1.4947321991892788 0.9997895922191427 0.0032840521504897977 4.678815076600762 0.22072582800805074 4.43752312646508 0.006785191868853493 2.042302713960548e-12 11.689879885530678 1.494732198971152 AVCMLSNTTAIAEAWAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVCMLSNTTAIAEAWAR 17 0 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2 P68363;P68366-2;Q71U36 TUBA1B;TUBA4A;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain 0 23790500.0 12001000.0 2568600.0 9220900.0 False True 9979363.23444441 2554762.441972822 11148947.557375483 1.0 0.25600455479512924 1.1172002957958458 23.250516331999172 -6.678203059290933 1.908459233776692 0.5284955240852356 1.1138606437285588 0.3157904328588814 0.31544990810731066 0.44255494219236113 3.1148872915037806 0.13271240474816887 0.3508038576524928 2.0979587299633025e-07 6.678203059290933 0.5853651196433232 AVCMLSNTTAVAEAWAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVCMLSNTTAVAEAWAR 17 0 Q9BQE3;F5H5D3;A0A1W2PQM2 Q9BQE3 TUBA1C Tubulin alpha-1C chain 0 8218600.0 1369700.0 4576500.0 2272400.0 False True 1795689.9641936673 3893704.0390572827 2037273.8463999887 1.0 2.1683609736081046 1.13453540812921 20.776106851624075 -6.616712404961191 2.1286412506494536 1.7770228193908928 1.1383989918930912 0.07184526083275 0.5028585574730932 0.5943627429303923 5.1127316789918 0.1944108321155357 0.5578404465075377 2.417060911450495e-07 6.616712404961191 -0.6386238274978016 AVCMLSNTTAVAEAWAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVCMLSNTTAVAEAWAR 17 0 Q9BQE3;F5H5D3;A0A1W2PQM2 Q9BQE3 TUBA1C Tubulin alpha-1C chain 0 7388000.0 1369700.0 2672900.0 3345400.0 False True 1876115.104750715 2554802.4399017002 2555285.420675727 1.0 1.361751437015995 1.3620088736587703 20.839316913146966 AVDCLLDSK(ub)WAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVDCLLDSKWAK 12 1 Q99442;F8WF48;F8WCJ7 Q99442 SEC62 Translocation protein SEC62 1 5267400.0 1824600.0 1350500.0 2092300.0 True False 2499203.9279609825 1290830.4444937133 1598141.832271126 1.0 0.5164966452124853 0.6394603555120838 21.253037195380443 -10.131814610518164 7.727189619469259 1.0000000825470288 0.5779785003623072 0.9401397598973538 0.0501997245189048 7.141435321110233e-08 7.96717965991497e-09 0.04860568367702732 0.016201891420493202 7.382192902804749e-11 10.131814610518164 -0.4220215821847215 AVDCLLDSK(ub)WAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVDCLLDSKWAK 12 1 Q99442;F8WF48;F8WCJ7 Q99442 SEC62 Translocation protein SEC62 1 13056500.0 4523600.0 5023200.0 3509700.0 True False 5855889.373486883 4743654.504252321 2870970.612563087 1.0 0.8100655940888646 0.49027063686716654 22.48145686853537 -6.963266422977896 0.3866544650166609 1.0203877590499837 0.26851928560658184 0.9998728255981729 0.002371976828879378 0.07855429144823572 0.016965625616621762 0.004137749641231669 0.026939624624902365 1.0882622814201879e-07 6.963266422977896 -0.7518684734434018 down AVDDGVNTFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVDDGVNTFK 10 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 13278610.0 638810.0 6531100.0 6108700.0 False True 837486.0962448401 5556685.338028409 5476630.322788063 1.0 6.634958315061872 6.539368650231256 19.675705713795928 -10.268292905258708 5.581708765080127 0.9995397270744046 6.587163482646705 0.9997805148911151 0.0390243172536104 0.0002235323222149689 2.9302881943382347e-05 0.03778690042133661 0.012595044234956615 5.391468780336244e-11 10.268292905258708 5.5876237555723005 AVDDGVNTFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVDDGVNTFK 10 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 12267710.0 638810.0 5405700.0 6223200.0 False True 874995.3201911404 5166858.299740588 4753408.330827156 1.0 5.905012496080438 5.432495718707143 19.73891577531882 -10.07436186887382 5.242887065068252 0.999934508518588 5.668754107401053 0.9923762248488933 0.19290416660352117 0.00014767346267903549 2.607212404758465e-05 0.1867811631606651 0.06225955205213118 8.426323553499628e-11 10.07436186887382 4.6688195988824654 AVDEMNGK(ub)ELNGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVDEMNGKELNGK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 11670800.0 2283000.0 2453800.0 6934000.0 True False 2210527.414651022 3433615.136397957 5117777.3844589135 1.0 1.553301313361013 2.315183856367989 21.075959195828695 -6.966640283763701 0.328685697574196 0.9057444303049885 2.9876331387258306 0.9999430738070227 0.0040679861994064774 0.07740866494372879 0.01292062171538137 0.01116972328720169 0.06652395691813175 1.0798407594509328e-07 6.966640283763701 2.081888708420842 AVDEMNGK(ub)ELNGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVDEMNGKELNGK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 22601400.0 4458700.0 6788700.0 11354000.0 True False 6764173.874632561 5577203.44464481 9109876.923365014 1.0 0.8245210055230537 1.346783375502729 22.689482314353864 -6.816080807715966 1.3886634418767807 0.9050253812743337 1.3572614434986285 0.8751435083059566 0.07667780774815124 0.19862767676119117 0.7536524333410222 0.04340127468792084 0.10015640715144218 1.5272818555920422e-07 6.816080807715966 0.4522360622242948 AVDEMNGK(ub)ELNGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVDEMNGKELNGK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 6210180.0 2283000.0 3101000.0 826180.0 True False 1898415.654048547 3084294.2974996916 998930.4181752843 1.0 1.6246675436552311 0.5261916251296036 20.85636447126297 -6.752450380953894 1.6408659752424501 1.3662224532528415 0.5236038092650989 0.6594394948247551 0.2625263978374335 0.2957760569163145 1.5675731020118884 0.12635116929625692 0.3059506652645111 1.7682742351957612e-07 6.752450380953894 -0.8426186439877427 AVDEMNGK(ub)ELNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVDEMNGKELNGK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 18626700.0 4458700.0 4711500.0 9456500.0 True False 5771875.044116621 4449300.883258644 7735514.0318838805 1.0 0.7708588369032519 1.3402081598715192 22.460608636446313 -6.797453081664189 1.4661856506430968 0.8731631098089964 1.3475923300268378 0.8246537804723476 0.09794642279049881 0.22440503686794044 0.952610332234241 0.05255990318194787 0.12243507772658065 1.5942150999835618e-07 6.797453081664189 0.4744292202178414 AVDIPHMDIEALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVDIPHMDIEALK 13 0 P62906 P62906 RPL10A 60S ribosomal protein L10a 0 11219300.0 1715800.0 4330700.0 5172800.0 False True 2249430.4158308376 3684576.4409363857 4637568.277001343 1.0 1.6380041876403055 2.061663363473475 21.10112830841785 -8.293640957797425 0.12193395451318571 6.5120753523649316e-15 3.1399407313763072 0.9999642680504797 0.0026083692332183905 0.09093232134806381 0.026295106838229988 0.31521180014262234 0.31354148095863316 5.0857972449413645e-09 8.293640957797425 3.1399407313763006 AVDIPHMDIEALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVDIPHMDIEALK 13 0 P62906 P62906 RPL10A 60S ribosomal protein L10a 0 11351000.0 3983000.0 2737000.0 4631000.0 False True 3856561.8451839704 3829898.3732664404 3418002.1729779597 1.0 0.9930862065778027 0.8862822146224159 21.878883815968177 -6.920069996571642 0.8242081882375601 1.0023506297928553 0.8690313921782218 0.9942002939895028 0.003964214570199953 0.09813068105510539 0.10540131661943845 0.0034168383917980998 0.010241900063956892 1.202070677591269e-07 6.920069996571642 -0.1333192376146335 AVDIPHMDIEALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVDIPHMDIEALK 13 0 P62906 P62906 RPL10A 60S ribosomal protein L10a 0 14438900.0 1715800.0 5870500.0 6852600.0 False True 2350177.627751537 5611121.898852533 5234157.01372705 1.0 2.3875309817414982 2.2271325162492825 21.16433836994074 -10.093749348426526 4.46746255187738 0.9998849056681623 2.3073317490673975 0.9888361394719912 0.06548239957472489 11388299.984724464 3.323786049928171 13692.417259460675 0.022416367067696345 8.058433967701379e-11 10.093749348426526 1.307446843399235 AVDIPHMDIEALKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVDIPHMDIEALKK 14 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 13535500.0 3590300.0 6544700.0 3400500.0 True False 4706918.068514662 5568256.271040794 3048648.879899293 1.0 1.1829940929475198 0.647695335997497 22.16635131014052 -6.814442298838163 1.3957401058537646 1.0992229459246263 0.637345772836215 0.8711030282264075 0.07975630390871094 0.2008163899082213 0.770141902616883 0.04491995238066053 0.10371792170426121 1.5330548773168893e-07 6.814442298838163 -0.46187717308841136 AVDIPHMDIEALKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVDIPHMDIEALKK 14 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 8033400.0 2313900.0 2453500.0 3266000.0 True False 2240446.511064822 3433195.344833479 2410536.6221002014 1.0 1.5323710375936521 1.0759179521561264 21.095354852992596 -10.00628963733315 4.234806517876252 0.99998224673465 1.304144494295993 0.3718510408723654 0.18634619220394566 129525452.00536047 326610228.09196216 37735.39789799697 0.06819574742329962 9.856219407244765e-11 10.00628963733315 0.304162247561343 AVDIPHMDIEALKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVDIPHMDIEALKK 14 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 50002200.0 9579800.0 6782400.0 33640000.0 True False 14533256.977191791 5572027.728866934 26991039.255064193 1.0 0.38339841768514554 1.8571913575479606 23.792854718750647 -6.793062650714989 1.4840284653554763 0.6567384759801439 1.8742244628254918 0.8110897413036601 0.2626691217209131 0.23082602922565607 1.004171368451603 0.13929200360862082 0.325410835544533 1.6104133024483784e-07 6.793062650714989 1.217485986845348 AVDIPHMDIEALKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVDIPHMDIEALKK 14 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 13117500.0 3590300.0 5245900.0 4281300.0 True False 4917730.934209316 5014118.792128522 3270145.116141261 1.0 1.0196000674312418 0.6649703206397652 22.22956137166341 -6.89382294454013 0.9994710716459873 1.017345316798983 0.6320799729972154 0.9832352429799949 0.021072815626572247 0.11609696869183399 0.20415709605319654 0.015978462508444247 0.04042468695849478 1.2769593001933418e-07 6.89382294454013 -0.3852653438017676 AVDIPHMDIEALKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVDIPHMDIEALKK 14 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 13907000.0 2313900.0 7196900.0 4396200.0 True False 1924110.3731506453 7158128.8712272 5315425.094267818 1.0 3.7202277848053393 2.7625364783850967 20.875760128426872 -10.303371307361505 5.845860105950118 0.9998102795783373 3.2413821315952136 0.8795660329041431 0.390975838638199 0.000966843123394827 0.00011521511895876503 0.3785902674797477 0.12618690931793058 4.973117181615426e-11 10.303371307361505 2.241571852016876 AVDIPHMDIEALKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVDIPHMDIEALKK 14 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 35739800.0 9579800.0 11548000.0 14612000.0 True False 12401239.946089316 10905343.648492146 11952765.931781016 1.0 0.8793752637558718 0.9638363569886635 23.563981040843096 -10.230381791679056 4.894041615955112 1.0000134196122676 0.9216058103721554 0.53459455881302 0.03448109692338496 5.0496817638657584e-06 7.941290101579096e-07 0.033391892911521365 0.011128726178547382 5.883262257597409e-11 10.230381791679056 -0.07840760924011225 AVDLIQK(ub)HK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVDLIQKHK 9 1 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 1 5684100.0 1912500.0 2624500.0 1147100.0 True False 2507306.0206763456 2232934.8302208753 1028409.0957601761 1.0 0.8905713190999084 0.410164968806944 21.257706659460336 -6.942743293368593 0.6335324970455259 1.0052430380296802 0.26944492457160196 0.9985015453736534 0.009916833537145911 0.08653722626215095 0.049076509869619006 0.009867175149985086 0.040874193275989165 1.1409239757442845e-07 6.942743293368593 -0.7357981134580782 down AVDLIQK(ub)HK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVDLIQKHK 9 1 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 1 7677510.0 1830910.0 2687100.0 3159500.0 True False 1772788.7642394663 3760073.04304138 2331932.167031716 1.0 2.120993272796642 1.3154032866584218 20.757589212193853 -10.241452131635539 4.917103414297399 0.9998662215847067 1.7181982797283393 0.5145018373560495 0.3288807346585268 0.0004824093257725821 7.441923398666685e-05 0.3184959697432671 0.1061458006846796 5.735190768984477e-11 10.241452131635539 0.7183320581436325 AVDLIQK(ub)HK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVDLIQKHK 9 1 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 1 4833990.0 1912500.0 1926120.0 995370.0 True False 2619602.933369164 1841017.6495729203 760284.1062886338 1.0 0.7027850007806803 0.2902287581846633 21.320916720983227 -7.116272402972502 0.3593097275688255 1.0398873900235692 4.1600170705011075e-11 0.9998845585742732 0.003126986251808309 0.07798394986771243 0.017144306554296024 0.006844702346485731 0.03627158755657867 7.65116551536259e-08 7.116272402972502 -1.039887389981969 down AVDLIQK(ub)HK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVDLIQKHK 9 1 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 1 7908610.0 1830910.0 3824900.0 2252800.0 True False 1522482.7880657138 3804294.5045167925 2723850.064229686 1.0 2.498743850726929 1.7890843072783023 20.53799448762813 -10.069683589142276 4.980952502753487 0.9999734216219139 2.143914079009232 0.7760047023742321 0.2897172954471935 8.551270109995197e-05 1.5971640227044397e-05 0.2805240549458212 0.09350585502799137 8.517583717690148e-11 10.069683589142276 1.143940657387318 AVDSLVPIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVDSLVPIGR 10 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4;K7ERX7 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 19724980.0 651380.0 10997000.0 8076600.0 False True 853965.4879728939 9356290.465970265 7240910.908217811 1.0 10.95628640471153 8.479161055332542 19.703818240609916 -10.497858737440524 6.844403651390266 0.9968117996263964 9.717723730022037 0.9429024106162078 1.0112821891486716 0.04909228855178113 0.003601663760323912 0.9770478448138006 0.32638992307408193 3.177907577578863e-11 10.497858737440524 8.72091193039564 AVDSLVPIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVDSLVPIGR 10 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4;K7ERX7 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 19410600.0 7414800.0 2245300.0 9750500.0 False True 7179421.232656325 3141859.999084816 7196551.541270061 1.0 0.43762023389765004 1.0023860291879543 22.77543611554079 -10.914338468970403 10.456842786628567 1.0355962305541107 0.7200031315428136 0.24683144783989797 0.23056467043973075 0.12441494170995888 0.001019194725243516 0.14516155193183508 0.07441442740307319 1.2180399450917823e-11 10.914338468970403 -0.31559309901129706 AVDSLVPIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVDSLVPIGR 10 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4;K7ERX7 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 35066380.0 651380.0 20124000.0 14291000.0 False True 892212.7888826184 19234855.138831146 10915760.132383794 1.0 21.55859608661329 12.234480684876056 19.767028302132807 -9.626511054876408 9.056350354678525 1.0000489429589352 16.896538385744677 0.7948931474103724 3.8065541729518935 0.0 0.0 3.685680064767689 1.2285600765074538 2.363137245217539e-10 9.626511054876408 15.896489442785741 AVEATGEK(ub)VLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVEATGEKVLR 11 1 Q9UBK9-2;Q9UBK9;S4R2Z4 Q9UBK9-2 UXT Protein UXT 1 9259060.0 460910.0 3210450.0 5587700.0 True False 604257.4734587893 2731463.3742360817 5009538.4050031705 1.0 4.520363411644869 8.290403718680402 19.204803885795908 -7.10113232016398 0.27021509522671316 9.626733190469753e-18 12.433672317521086 0.9999753872707727 0.014768646202217869 0.07949476710974424 0.011221926321943302 0.09260196453412485 0.3794247969549471 7.922599091935118e-08 7.10113232016398 12.433672317521086 AVEATGEK(ub)VLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVEATGEKVLR 11 1 Q9UBK9-2;Q9UBK9;S4R2Z4 Q9UBK9-2 UXT Protein UXT 1 10336640.0 2758450.0 4314990.0 3263200.0 True False 2670884.5146491937 6037988.009375581 2408470.026098402 1.0 2.2606698179043647 0.9017499681803882 21.34888616650841 -6.662983323975351 1.9623836635965262 1.8094382596421146 0.9073751720455312 0.2485240029545127 0.5363756109849573 0.47728243626647976 3.536357142064166 0.22059441987673656 0.5947891108700829 2.1727846077709724e-07 6.662983323975351 -0.9020630875965834 AVEATGEK(ub)VLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVEATGEKVLR 11 1 Q9UBK9-2;Q9UBK9;S4R2Z4 Q9UBK9-2 UXT Protein UXT 1 45848000.0 5650700.0 9711300.0 30486000.0 True False 8572525.021505423 7978242.640266781 24460428.73751153 1.0 0.9306759234008884 2.853351687647338 23.031288779432778 -6.898532509839975 0.970470624563855 0.9168117466508604 3.0492801178265445 0.9858227957086619 0.10602631019472518 0.11249452918205567 0.18356220119245062 0.08215873169617476 0.2122381796881452 1.2631865423263085e-07 6.898532509839975 2.132468371175684 up AVEATGEK(ub)VLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVEATGEKVLR 11 1 Q9UBK9-2;Q9UBK9;S4R2Z4 Q9UBK9-2 UXT Protein UXT 1 12524930.0 460910.0 2704120.0 9359900.0 True False 631320.8826244086 2584643.037070966 7149284.393191466 1.0 4.094024303974507 11.324327437850311 19.2680139473188 -6.9568915990954 0.47723617975252686 0.8218569828561485 14.896536820032033 0.9996369478192288 0.08243060220488724 0.08083089149184748 0.02538110867479327 0.10138055805552972 0.5965042552566384 1.1043542348683446e-07 6.9568915990954 14.074679837175884 AVEATGEK(ub)VLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVEATGEKVLR 11 1 Q9UBK9-2;Q9UBK9;S4R2Z4 Q9UBK9-2 UXT Protein UXT 1 20954150.0 2758450.0 6036900.0 12158800.0 True False 2293773.3950548456 6004378.021469163 14701148.864060683 1.0 2.6176857898927692 6.409154843174545 21.129291441942687 -6.956829352118006 0.4780289009868004 0.9072843043362526 8.277106856050288 0.9996339275865724 0.04337338133013016 0.08085381155827975 0.025468567588611483 0.05324672677557823 0.31278794339032967 1.104512532158786e-07 6.956829352118006 7.369822551714035 AVEATGEK(ub)VLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVEATGEKVLR 11 1 Q9UBK9-2;Q9UBK9;S4R2Z4 Q9UBK9-2 UXT Protein UXT 1 45994700.0 5650700.0 2821500.0 37522500.0 True False 7314942.5419494035 2664481.044702164 30693790.013362538 1.0 0.36425180777866917 4.196039796258299 22.802415101525227 -6.864273458388 1.163876297336315 0.650276748472968 4.397395737714641 0.9586307529779146 0.341028141826861 0.1424685142491736 0.3643090361849481 0.22809412702589074 0.5353002670731576 1.3668678908886698e-07 6.864273458388 3.747118989241673 up AVECCDK(ub)ALGLDSANEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVECCDKALGLDSANEK 17 1 Q13451 Q13451 FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5;Peptidyl-prolyl cis-trans isomerase FKBP5, N-terminally processed 1 12661400.0 2879100.0 3850000.0 5932300.0 True False 4367805.190404069 3162937.419812706 4759778.304780548 1.0 0.7241480061339687 1.0897414370122624 22.058477081006508 -6.704899406009332 1.8138053117518118 0.8295339056090053 1.0887455981926124 0.44072395320174984 0.11633949595765566 0.3853879100618364 2.46828514537908 0.05111089537968004 0.1306347637464808 1.9728796538591058e-07 6.704899406009332 0.2592116925836071 AVECCDK(ub)ALGLDSANEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVECCDKALGLDSANEK 17 1 Q13451 Q13451 FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5;Peptidyl-prolyl cis-trans isomerase FKBP5, N-terminally processed 1 10750300.0 2879100.0 1757100.0 6114100.0 True False 3727051.7055456024 1659315.8403849634 5001396.535963753 1.0 0.4452086988533089 1.3419176687358567 21.829603403098957 -6.739343732262625 1.689064781242712 0.6696533530554298 1.342372740604835 0.6020190836217749 0.23310326673323428 0.3189990338361954 1.7866996333044272 0.10918813222299956 0.26813468120149275 1.8224527096306267e-07 6.739343732262625 0.6727193875494051 AVEDIHGLFSLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVEDIHGLFSLSK 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 8691600.0 2087000.0 2696100.0 3908500.0 False True 2736077.2105367477 2293852.3893154897 3504085.9129793877 1.0 0.8383726820580093 1.2806970137703009 21.383677512152794 -6.807846251817112 1.423831862527358 0.9116879233667659 1.2880403084183922 0.8540557567678386 0.06981382688487016 0.2097584061097115 0.8385534761842722 0.0385610837773807 0.0892790233647331 1.556516569387636e-07 6.807846251817112 0.3763523850516264 AVEDIHGLFSLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVEDIHGLFSLSK 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 7289920.0 2065700.0 833320.0 4390900.0 False True 2000125.4842070148 1166069.0217063914 3240791.5658235657 1.0 0.5829979323365804 1.6202941222502523 20.93165908420624 -6.797583114800102 1.4656615682321164 0.7692114323616872 1.6337890878011008 0.8250305219602383 0.17826693975726784 0.22422545696348667 0.9511573153218709 0.09569467249028663 0.2228959346811422 1.5937378437293483e-07 6.797583114800102 0.8645776554394136 AVEDIHGLFSLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVEDIHGLFSLSK 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 7449700.0 2087000.0 2933200.0 2429500.0 False True 2858620.299054349 2803601.5252047107 1855702.1371231165 1.0 0.9807533816688285 0.6491600642929023 21.446887573675685 -6.918823478398487 0.8334061493287317 1.00763127116438 0.5971084057590315 0.993847802663972 0.012631547357752957 0.09886905554279836 0.10923788557519276 0.010816098345431737 0.032043764905438775 1.2055258340232662e-07 6.918823478398487 -0.41052286540534855 AVEEK(ub)IEWLESHQDADIEDFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVEEKIEWLESHQDADIEDFK 21 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 18949800.0 1664800.0 4326000.0 12959000.0 True False 1611951.8352654462 6053394.359791975 9564649.138333295 1.0 3.755319623923589 5.933582461388028 20.620377206451963 -7.782905385224932 0.25811757527084744 5.3115568176181564e-21 7.933656407712449 0.9996601971239966 0.03721245190977082 0.12919526331018166 0.04003835946887068 0.33513333783795 0.6135150411574307 1.6485214969439975e-08 7.782905385224932 7.933656407712449 AVEEK(ub)IEWLESHQDADIEDFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVEEKIEWLESHQDADIEDFK 21 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 18019800.0 1664800.0 1734900.0 14620100.0 True False 1384354.963144991 1725553.7493493117 17677095.314295262 1.0 1.2464677017729484 12.769192717838974 20.40078248188624 -6.911518728396618 0.8853359223804438 0.6601424571572982 14.307682590013872 0.9914820320008523 0.5067688688458674 0.10342207660578207 0.1333856450918308 0.4180396113847955 1.1664790512348115 1.2259740329686176e-07 6.911518728396618 13.647540132856573 up AVEEMNGK(ub)EISGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVEEMNGKEISGK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 8740600.0 3073400.0 2988000.0 2679200.0 True False 4029257.1628479334 2542202.0471327766 2401982.08470113 1.0 0.6309356649094876 0.5961352149097817 21.942082456152356 -13.999999999999998 0.334017708779428 5.11619845114057 0.5902582361747047 0.9997231189114302 0.003040646030409525 19.168428481456623 0.18503484944369636 55.54288345861562 0.010987350589356959 1.0000000000000041e-14 13.999999999999998 -4.525940214965865 AVEEMNGK(ub)EISGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVEEMNGKEISGK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 8301000.0 2413400.0 2339100.0 3548500.0 True False 2336787.9380283705 3273114.82824536 2619041.397281865 1.0 1.4006897138501155 1.1207869377705029 21.15609538575712 -10.18894834452053 5.56518942806701 0.999992010261856 1.2607383258103282 0.5363935452307592 0.11426982983066131 1.1328594789666835e-05 1.650802412799854e-06 0.11064467559567834 0.03688042899233204 6.472195922048447e-11 10.18894834452053 0.26074631554847216 AVEEMNGK(ub)EISGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVEEMNGKEISGK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 31329600.0 4896900.0 7753100.0 18679600.0 True False 7428955.3113437155 6369498.729753216 14987568.872440493 1.0 0.8573882144676853 2.0174530932438213 22.824727916950685 -6.876134970825229 1.1011765444126662 0.9154247313533481 2.093792753411987 0.9704295687047416 0.08882408323134403 0.13110644666592178 0.2934715660545343 0.06233934649402908 0.14937312624233376 1.3300410011902722e-07 6.876134970825229 1.178368022058639 up AVEEMNGK(ub)EISGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVEEMNGKEISGK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 8520500.0 3073400.0 3016600.0 2430500.0 True False 4209719.035512042 2883316.637437792 1856465.9577187626 1.0 0.6849190202754433 0.4409952165591389 22.005292517675247 -7.494642693941593 0.17333760576703464 1.2466401087271914 1.2193430753376574e-12 0.9999738061853933 0.0011711261601704103 0.1295858182479918 0.015559154874442208 0.035366064037069975 0.06606841121513407 3.201528011931723e-08 7.494642693941593 -1.2466401087259722 down AVEEMNGK(ub)EISGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVEEMNGKEISGK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 7774800.0 2413400.0 3343700.0 2017700.0 True False 2006849.0317480322 3325686.8244275125 2439591.7412092676 1.0 1.6571684126786201 1.2156329163854953 20.936500661191396 -10.238415439475036 4.121837889891214 0.9996841093368932 1.436400664565044 0.5656897863500019 0.1802561116473728 96149163.39112024 160.5601189535473 289073.63443437143 0.06596698217310235 5.7754331395754974e-11 10.238415439475036 0.4367165552281508 AVEEMNGK(ub)EISGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVEEMNGKEISGK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 31525100.0 4896900.0 7645600.0 18982600.0 True False 6339133.582329988 7220115.6389774615 15527961.577924073 1.0 1.138975152551315 2.449540047745243 22.595854239043135 -6.927170526834571 0.7696573115589606 0.9778409266076176 2.7001852471875774 0.9959525113738821 0.04154583424124204 0.09413347648743076 0.08507256587229649 0.0372318994493779 0.12048069077568188 1.1825771226312061e-07 6.927170526834571 1.7223443205799598 up AVEHINK(ub)TIAPALVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVEHINKTIAPALVSK 16 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 5259500.0 1784300.0 2247000.0 1228200.0 True False 2339234.5791857815 1911756.3587374 1101117.6457263087 1.0 0.817257224114234 0.47071706938838737 21.157605112185404 -6.961072360746708 0.4200472310678826 1.015309909374853 0.2595909979364046 0.9998079261520193 0.0030420717240620485 0.07932024911864993 0.019732179130781558 0.004482926506594151 0.02884644314549742 1.0937741099724093e-07 6.961072360746708 -0.7557189114384484 down AVEHINK(ub)TIAPALVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVEHINKTIAPALVSK 16 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 18515800.0 7090800.0 5745200.0 5679800.0 True False 6865706.435307681 8039288.320822212 4192089.989652397 1.0 1.1709338866397276 0.6105839259444731 22.710976741011972 -6.824857405653232 1.3508434509619414 1.0917060448527727 0.5970399731657237 0.8951714968464584 0.07592023989530075 0.18724278730058672 0.6700251039116931 0.04415058016964355 0.10164658388432041 1.4967270042112045e-07 6.824857405653232 -0.494666071687049 AVEHINK(ub)TIAPALVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVEHINKTIAPALVSK 16 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 41314100.0 8997300.0 10541800.0 21775000.0 True False 13649561.890737556 8660533.426540667 17471161.705678467 1.0 0.6344916778916992 1.2799796686173648 23.70235130999375 -6.753043403405273 1.6382560576392584 0.7858763470729232 1.2815955435941515 0.6621473715227824 0.15361842083082325 0.29473789597136696 1.5572038342318486 0.07404125826320762 0.17920456782279828 1.765861331625688e-07 6.753043403405273 0.4957191965212283 AVEHINK(ub)TIAPALVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVEHINKTIAPALVSK 16 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 14935800.0 7090800.0 4980000.0 2865000.0 True False 5896314.375701888 4953171.751547401 3464058.253736702 1.0 0.840045397165205 0.5874955155057087 22.49138201644625 -6.964391456089637 0.3683474549621532 1.0197887872871638 0.39898402275305367 0.999900044715919 0.001697736460042408 0.07816808074291627 0.015591807459117042 0.0033373969891088515 0.02146811950273566 1.0854468031792638e-07 6.964391456089637 -0.6208047645341102 AVEHINK(ub)TIAPALVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVEHINKTIAPALVSK 16 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 25413400.0 8997300.0 5160700.0 11255400.0 True False 11647182.213297704 4873502.50838011 9207032.690156585 1.0 0.4184276006960708 0.7904944321764644 23.4734776320862 -10.222488403311004 7.276865625693066 1.000000869644755 0.6044610164362961 0.601095980067974 0.1518956478901769 2.1432165912510875e-06 2.2888758422264314e-07 0.14707265297807065 0.04902410955333674 5.99116936235802e-11 10.222488403311004 -0.39553985320845897 AVELAANTK(ub)GICFIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVELAANTKGICFIR 15 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 32539600.0 3640300.0 8363300.0 20536000.0 True False 5522601.241578251 6870803.77223885 16477050.59875144 1.0 1.2441245477783778 2.9835669602034534 22.396916530959782 -6.932316985744935 0.7275282698198656 0.9756891435487478 3.362683294101428 0.9969742504707411 0.0485799911563422 0.09145253077916424 0.07191795908794421 0.044885068116136274 0.15543295716908176 1.1686461004666119e-07 6.932316985744935 2.38699415055268 up AVELGEK(ub)ASGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVELGEKASGK 11 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 22233500.0 9552000.0 7527600.0 5153900.0 True False 12522764.50169959 6404511.422354974 4620623.8676997395 1.0 0.5114295187365181 0.368977941497872 23.578049748257765 -13.999999999999998 0.17279730257916057 3.4824372285449496 0.2469895870212062 0.9995086204225396 0.005990044637153711 12.119970862443774 0.13168638444935113 10.088235698048134 0.11324650452561497 1.0000000000000041e-14 13.999999999999998 -3.2354476415237436 AVELGEK(ub)ASGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVELGEKASGK 11 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 32376500.0 12904000.0 10880000.0 8592500.0 True False 12494369.583292501 15224440.738450471 6341866.480525406 1.0 1.2185041139497448 0.5075779484709468 23.574774774759636 -6.82421049596776 1.3537248246228755 1.1172956737778144 0.490632114148409 0.8937584264032589 0.0969134758441898 0.18806886529422642 0.6760623517571174 0.056242371461668716 0.1294964781129488 1.4989581370656875e-07 6.82421049596776 -0.6266635596294053 AVELGEK(ub)ASGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVELGEKASGK 11 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 47056000.0 13256000.0 16814000.0 16986000.0 True False 20110321.143411595 13813410.331618374 13628709.654771725 1.0 0.6868816381952124 0.6776972658756705 24.261432784557336 AVELGEK(ub)ASGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVELGEKASGK 11 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 23182900.0 9552000.0 8530300.0 5100600.0 True False 13083632.533093994 8153403.140070149 3895943.330154421 1.0 0.6231757976576285 0.29777229835062596 23.641259809780657 -7.626935253102826 0.2653146934079209 1.1267144158182296 6.931790760593822e-12 0.9997542079657876 0.004498561259305261 0.1286163669759466 0.03227752399866549 0.03341780433968454 0.0742872646044818 2.360830171878856e-08 7.626935253102826 -1.1267144158112978 down AVELGEK(ub)ASGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVELGEKASGK 11 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 30791400.0 12904000.0 13483000.0 4404400.0 True False 10730247.744127221 13410364.402834028 5325339.6763553005 1.0 1.24977211361906 0.49629233204516787 23.355180050193912 -6.817341217126632 1.3832040970607917 1.1349979833689623 0.4807435405610793 0.8781988244767411 0.10936821904180914 0.19695093831879024 0.7411108212125629 0.062143811759870445 0.14335227885538732 1.5228558040626477e-07 6.817341217126632 -0.6542544428078829 down AVELGEK(ub)ASGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVELGEKASGK 11 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 44119900.0 13256000.0 20877000.0 9986900.0 True False 17160153.314824942 19715176.597642064 8169386.674247457 1.0 1.1488928004279422 0.4760672311237329 24.032559106649785 -6.848655757623648 1.241442491913202 1.0793786537649785 0.4498433545318507 0.9383365809264786 0.07165398780372241 0.15894783842538937 0.47205832587468727 0.0451776707250658 0.10446542479615135 1.4169164500469286e-07 6.848655757623648 -0.6295352992331278 down AVELLRK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVELLRK 7 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 43454900.0 14316000.0 6652900.0 22486000.0 False True 18768414.636341225 5660313.252801092 20159364.42094269 1.0 0.30158718050916483 1.074111202866766 24.161803455409345 -6.668625219571345 1.9424439793441077 0.5536699435966751 1.0709552404648002 0.272856132307592 0.2967668420290909 0.464300990041315 3.376130063364579 0.12306005572076291 0.3293524644562453 2.1447406363384718e-07 6.668625219571345 0.5172852968681251 AVELLRK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVELLRK 7 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 27103900.0 8178800.0 2588100.0 16337000.0 False True 7919168.47084878 3621541.826763201 12057849.600505512 1.0 0.4573133959827278 1.5226156186589053 22.916917521603413 -6.768221366493859 1.5812267456144538 0.6880213505069455 1.5282130759705015 0.7237155360661238 0.22861311017746416 0.2693199556410642 1.3286502905985842 0.11397876588128639 0.2717657915693001 1.705212994486641e-07 6.768221366493859 0.840191725463556 AVELLRK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVELLRK 7 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 216496000.0 19630000.0 86436000.0 110430000.0 False True 29780145.145230077 71010820.47244957 88603462.09681155 1.0 2.3845021616297752 2.975252862761929 24.82784744968942 -9.512179348936364 0.24692474201560657 8.911369224609812e-18 3.3479812232091395 0.9991161815882418 0.02461009573139594 0.9179980714948655 0.09910295293493321 0.9756090500014433 0.26271728994578775 3.07482675303163e-10 9.512179348936364 3.3479812232091395 AVELLRK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVELLRK 7 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 45803000.0 14316000.0 14544000.0 16943000.0 False True 19609012.075353194 13901397.989423586 12941412.352038266 1.0 0.7089290340586012 0.6599726851259623 24.225013516932236 -13.999999999999998 0.2508192974700448 3.0326508537141934 0.640440950553405 0.9995442332683242 0.0032041770704821747 14.030679723338379 0.15847583076925917 14.37602074020981 0.022490745450191352 1.0000000000000041e-14 13.999999999999998 -2.392209903160788 AVELLRK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVELLRK 7 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 16063700.0 8178800.0 3836700.0 4048200.0 False True 6801034.582274308 3816030.9355746773 4894659.903238022 1.0 0.5610956523468482 0.7196934295842409 22.69732279703769 -10.04413864400037 5.694813365260329 1.000001295311587 0.6403945409654497 0.8726899004976587 0.06474727142886967 1.0648420592514783e-06 1.7880404652611757e-07 0.06269150110656141 0.02089709199631643 9.033610390604372e-11 10.04413864400037 -0.3596067543461374 AVELLRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVELLRK 7 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 250930000.0 19630000.0 130630000.0 100670000.0 False True 25411421.965148903 123360325.66700132 82349092.9614286 1.0 4.854522735334794 3.240633014333799 24.598973771781868 -9.458293286243345 10.398596032385605 1.0000000000003055 4.047577874821794 0.8262215666531506 0.6588677195958579 0.0 0.0 0.6379459263371037 0.21264864211236784 3.4810215650064853e-10 9.458293286243345 3.0475778748214886 AVEVQGPSLESGDHGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVEVQGPSLESGDHGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 8637150.0 574550.0 4311100.0 3751500.0 False True 753240.6139501152 3667900.6845361805 3363330.766929044 1.0 4.869494045602663 4.465147928350803 19.52275126510157 -10.251797864565159 4.670942660430131 0.9988263471687435 4.667320986990001 0.9909649973241857 0.16507361116920785 0.002017862652537473 0.0003232261444847213 0.15985686376096048 0.05327727890662912 5.600181923756812e-11 10.251797864565159 3.6684946398212572 AVEVQGPSLESGDHGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVEVQGPSLESGDHGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9956450.0 574550.0 4530200.0 4851700.0 False True 786976.6616299368 4330040.784631931 3705828.3838980137 1.0 5.502120959551484 4.708943180376829 19.58596132662446 -9.987495523042433 6.642702088100432 0.9999992287270842 5.105532069964186 0.9727684159375821 0.3238134723820817 3.7010972784899985e-06 5.65473284978572e-07 0.3135311024723238 0.10451034881776762 1.0292111368407147e-10 9.987495523042433 4.1055328412371015 AVEYAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVEYAVR 7 0 Q8TD30 Q8TD30 GPT2 Alanine aminotransferase 2 0 7157950.0 1947900.0 733350.0 4476700.0 False True 1886064.9807265527 1026180.4793697284 3304117.971878743 1.0 0.5440854317619649 1.751857971831875 20.846947951464962 -6.804437092054438 1.4377597517230218 0.7498498537364281 1.7704092998643801 0.8448117619731987 0.19617421058229903 0.21448439602926775 0.8748081551448331 0.10731875751509204 0.24893694088096496 1.5687831208664798e-07 6.804437092054438 1.020559446127952 AVEYLLMGIPGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVEYLLMGIPGDR 13 0 P54727;P54727-2 P54727 RAD23B UV excision repair protein RAD23 homolog B 0 13382400.0 2584700.0 5236200.0 5561500.0 False True 3388566.7302704053 4454979.370547742 4986049.32967503 1.0 1.3147090570036486 1.4714331239618665 21.69224375171989 -11.933893163228689 0.11185896484945097 1.4392830414005118e-11 1.7869471278572344 0.9998020056592873 0.0027583553627690584 5.4333773411377315 0.07996582495574585 1.5268965249657902 0.23591620523066842 1.1644124405222064e-12 11.933893163228689 1.7869471278428415 AVEYLLMGIPGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVEYLLMGIPGDR 13 0 P54727;P54727-2 P54727 RAD23B UV excision repair protein RAD23 homolog B 0 9102300.0 2584700.0 0.0 6517600.0 False True 3540333.438891126 0.0 4978277.114185483 1.0 0.0 1.4061605213504236 21.75545381324278 -6.715700274971191 1.7745886064472018 0.3888417560084962 1.403489540932191 0.4922512876057481 0.4210404191635029 0.36373252212807095 2.236121830544067 0.18855549969441177 0.4757909320273459 1.9244193941056316e-07 6.715700274971191 1.0146477849236948 AVEYNALFKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVEYNALFKK 10 1 O43747;O43747-2 O43747 AP1G1 AP-1 complex subunit gamma-1 1 8246500.0 2020400.0 2947900.0 3278200.0 True False 2615447.628038041 2783846.7735876404 2681601.237172501 1.0 1.064386357327263 1.025293417625833 21.31862645097217 -10.520225321102592 5.474929110051272 0.9998940911732382 1.044839887476548 0.6369138706162962 0.01595962580231591 2.0680401959249267e-05 1.8122538994753364e-06 0.015489316733903543 0.00515094707867261 3.01838531237219e-11 10.520225321102592 0.04494579630330986 AVFPSIVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVFPSIVGR 9 0 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I 0 231003000.0 30668000.0 103400000.0 96935000.0 False True 40206044.989334434 87973123.05004328 86905096.06617796 1.0 2.188057121096595 2.1614932801580338 25.26090909149868 -10.244593817174382 5.631192118401215 0.9999345249374428 2.1747752006273107 0.9996166750561578 0.010844642651432116 8.91578464094931e-06 1.1960270509164464e-06 0.010500857608531646 0.003500093365364559 5.6938521109408955e-11 10.244593817174382 1.1748406756898677 AVFPSIVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVFPSIVGR 9 0 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I 0 213411000.0 72129000.0 28812000.0 112470000.0 False True 69839304.37641846 40316781.85259505 83010732.9723238 1.0 0.5772792586148409 1.188596216894061 26.057535853509798 -6.7206958168133735 1.7568721328152173 0.743008731904299 1.1876753654233205 0.5157352549196187 0.17786793986832 0.35398616362250807 2.135709928955397 0.08037615831824751 0.20160465681847034 1.9024102761495887e-07 6.7206958168133735 0.4446666335190216 AVFPSIVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVFPSIVGR 9 0 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I 0 307658100.0 24833000.0 274050000.0 8775100.0 False True 37673476.53548133 225143636.33757704 7040697.638737034 1.0 5.976184229388389 0.18688738832228616 25.167045836574903 -6.679242570874661 1.9045783951080342 4.150715250323081 0.20912984852083977 0.32055957427786663 2.1093941266290237 0.440273859199547 3.0870967078721296 0.8889105688713048 2.346719462154073 2.0929431366985024e-07 6.679242570874661 -3.9415854018022416 AVFPSIVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVFPSIVGR 9 0 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I 0 231489000.0 30668000.0 87091000.0 113730000.0 False True 42006788.3715375 83243031.648576 86869316.3428739 1.0 1.9816566530227506 2.067982812076485 25.32411915302157 -10.934390791407136 0.44222234863606 2.122220814128498e-10 2.0697427378720916 0.999625002358631 0.009380110152817797 2.6710035010860516 0.21465857848352304 2.7704039187099014 0.019795690205309326 1.1630789844921145e-11 10.934390791407136 2.0697427376598694 AVFPSIVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVFPSIVGR 9 0 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I 0 113399000.0 72129000.0 20888000.0 20382000.0 False True 59978459.356490344 20775472.19805661 24643781.964279722 1.0 0.34638222490135484 0.41087720872932004 25.837941128944074 -10.112177488098476 5.174662311815772 1.0000158186270878 0.37862971682496505 0.991984747715051 0.026329966894243106 4.8052490292499984e-06 8.243985595665139e-07 0.025494528744851305 0.008497960273537492 7.72364869391973e-11 10.112177488098476 -0.6213861018021227 AVFPSIVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVFPSIVGR 9 0 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I 0 50529000.0 24833000.0 14530000.0 11166000.0 False True 32146808.031611953 13721392.727103498 9133902.572835125 1.0 0.42683530861323465 0.28413093343056617 24.938172158667353 -13.999999999999938 0.19526311555491008 4.130446397870749 0.1870033939139109 0.999487365482963 0.0070044260856730435 12.441199824847397 0.140129011633757 14.84629417720234 0.09418392834825409 1.0000000000001431e-14 13.999999999999938 -3.9434430039568378 AVFPSIVGRPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVFPSIVGRPR 11 1 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I 0 340062400.0 63166000.0 83289000.0 193607400.0 False True 82811237.70041408 70862605.85797918 173574763.46131876 1.0 0.8557124349999281 2.096029093168002 26.303323222691745 -6.877914787058289 1.091307723389087 0.912805716838542 2.180507771365208 0.9719666290766329 0.09272760229577631 0.12949582557734662 0.2835533210946943 0.06556934428829028 0.1577638595880732 1.3246014098067642e-07 6.877914787058289 1.2677020545266662 up AVFPSIVGRPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVFPSIVGRPR 11 1 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I 0 286202700.0 85065000.0 51457700.0 149680000.0 False True 82364658.13722686 72005027.95836051 110474317.69625165 1.0 0.8742223859946545 1.341283023504955 26.295522088176856 -6.8350187602569275 1.3053826071739987 0.9329901420408541 1.3551854810065636 0.9155343410270926 0.05734895532436904 0.17469982070729453 0.580416219557426 0.0344751271137056 0.07934673347170401 1.4621140140249098e-07 6.8350187602569275 0.4221953389657095 AVFPSIVGRPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVFPSIVGRPR 11 1 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I 0 701053100.0 86626100.0 550887000.0 63540000.0 False True 131418126.91621056 452576910.7502241 50981291.14942871 1.0 3.443793648335725 0.38793195692047344 26.969589043955896 -6.693699573418741 1.853204087967262 2.5266864253180055 0.3979223007464677 0.38797628167778986 1.0327751064447064 0.4086746322141025 2.72397879610047 0.4453530453757665 1.154379488664435 2.0244191020571296e-07 6.693699573418741 -2.128764124571538 AVFPSIVGRPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVFPSIVGRPR 11 1 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I 0 314706000.0 63166000.0 138550000.0 112990000.0 False True 86520177.19696547 132428402.87641925 86304089.10209545 1.0 1.530607162014272 0.997502454319088 26.366533284214636 -10.758754661272075 2.8253578641187294 0.9450449234161569 1.2640548078128766 0.24648638265080003 0.2176390877016213 87218832.87881501 75864651.79937442 33494149.575983 0.08471510670391443 1.7427911212375117e-11 10.758754661272075 0.31900988439671973 AVFPSIVGRPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVFPSIVGRPR 11 1 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I 0 179737300.0 85065000.0 53189000.0 41483300.0 False True 70735316.51845793 52902460.29981009 50157266.23289203 1.0 0.7478931727972904 0.7090837887154121 26.075927363611132 -13.999999999999998 0.26342535453450616 2.878974002976096 0.6953577928662814 0.9995693981217504 0.0026762160677815004 14.571358802964063 0.16243137487570744 14.604779020602464 0.016666305018165888 1.0000000000000041e-14 13.999999999999998 -2.1836162101098147 AVFPSIVGRPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVFPSIVGRPR 11 1 C9JTX5;F8WCH0;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63267-2;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;POTEE;POTEF;POTEI Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I 0 405148000.0 86626100.0 124887300.0 193634600.0 False True 112139194.10571493 117937211.97024018 158395089.65877667 1.0 1.051703758982425 1.4124864274435196 26.740715366048345 -6.932729811136695 0.7240281927765415 0.9950308874432474 1.4919811122284112 0.997048216554771 0.009968496634613416 0.0912446963593277 0.07091483477024522 0.009234045896524486 0.03216855525026431 1.1675357535054412e-07 6.932729811136695 0.4969502247851638 AVFQFYQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVFQFYQR 8 0 Q9BVJ7 Q9BVJ7 DUSP23 Dual specificity protein phosphatase 23 0 7189900.0 2150700.0 2475500.0 2563700.0 False True 2819588.5274084294 2106165.0494234255 2298432.9167468995 1.0 0.7469760317684604 0.815166076327974 21.427053209685674 -9.797462181779524 5.710701400169474 1.0000000297145244 0.7810710540468438 0.9321743438030015 0.02783846912293406 1.0535878220161523e-08 2.1803361601453487e-09 0.026954485437009075 0.00898482727404508 1.594181695485254e-10 9.797462181779524 -0.21892897566768055 AVFVDLEPTVIDEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVFVDLEPTVIDEVR 15 0 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8VRK0;P68363;P68363-2;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 89585000.0 22318000.0 49744000.0 17523000.0 False True 29259114.127819464 42322389.100593336 15709888.052485038 1.0 1.4464685743972459 0.5369228878173086 24.802382754168146 -6.773230190162667 1.562021038024317 1.2550285569004238 0.5311647910136704 0.7427597090584298 0.18833998129301177 0.2612527176989288 1.2584059790340205 0.09501318664278045 0.22551365106229396 1.685659334441896e-07 6.773230190162667 -0.7238637658867534 AVFVDLEPTVIDEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVFVDLEPTVIDEVR 15 0 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8VRK0;P68363;P68363-2;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 185334000.0 77070000.0 36513000.0 71751000.0 False True 74623455.03598517 51092831.31277952 52957260.61613941 1.0 0.6846752309731755 0.7096597254925034 26.153125822113328 -10.751105333658465 6.898915585576437 1.0058089710776275 0.6971674782328853 0.9949209081264153 0.010199877175619385 0.0009209795557419925 3.3226468562192705e-05 0.009980532671846919 0.00329199620287792 1.7737592216644242e-11 10.751105333658465 -0.3086414928447422 AVFVDLEPTVIDEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVFVDLEPTVIDEVR 15 0 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8VRK0;P68363;P68363-2;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 1624390000.0 160590000.0 1355300000.0 108500000.0 False True 243626770.7016046 1113436125.9927676 87054927.44276059 1.0 4.570253600563914 0.35732907016768667 27.860097430259398 -6.6821281897705 1.8941413419727058 3.2546251458472173 0.37303662744245875 0.33390744906382097 1.5124630938131656 0.4338520701727373 3.011215318183627 0.6402629801916798 1.6841745993976576 2.079082918081185e-07 6.6821281897705 -2.8815885184047585 AVFVDLEPTVIDEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVFVDLEPTVIDEVR 15 0 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8VRK0;P68363;P68363-2;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 90664000.0 22318000.0 27708000.0 40638000.0 False True 30569567.72127218 26483768.94189694 31040141.36588157 1.0 0.8663442408924844 1.015393532839587 24.865592815691038 -11.771612580490139 15.56854864394834 0.9419386455940322 0.9467819986842767 0.0 0.06833723036470722 0.0 0.0 0.0 0.019989184743246312 1.6919495899911762e-12 11.771612580490139 0.004843353090244529 AVFVDLEPTVIDEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVFVDLEPTVIDEVR 15 0 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8VRK0;P68363;P68363-2;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 171586000.0 77070000.0 62307000.0 32209000.0 False True 64087119.77990426 61971339.82402884 38943752.98241026 1.0 0.9669858785487366 0.6076689530775545 25.933531097547604 -6.92485165125875 0.7879068092215163 1.0066298992196014 0.5427253734675005 0.9954259353327345 0.012016623578607126 0.09540064888093713 0.09143254487153268 0.010629153637795943 0.0334793689079233 1.1889082720292207e-07 6.92485165125875 -0.46390452575210095 AVFVDLEPTVIDEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVFVDLEPTVIDEVR 15 0 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8VRK0;P68363;P68363-2;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 498813000.0 160590000.0 268670000.0 69553000.0 False True 207886920.70215297 253718278.32008904 56895067.67404631 1.0 1.2204629202411454 0.2736827669671528 27.631223752351847 -6.845372206318679 1.2571007671857528 1.1173421547239881 0.23906019656741506 0.9333050451809595 0.10446186989351683 0.16262944386720626 0.49687864064336906 0.06509094801196406 0.1502551342100552 1.427669868538329e-07 6.845372206318679 -0.8782819581565731 down AVFVSEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVFVSEGK 8 0 P31146;H3BRY3;H3BTU6;H3BRJ0 P31146 CORO1A Coronin-1A;Coronin 0 6804170.0 2160200.0 585570.0 4058400.0 False True 2091625.6334336966 819391.1547072101 2995383.290609752 1.0 0.3917484762137213 1.4320838503458242 20.996193225344967 -6.748255640788673 1.6564769813427347 0.6415839357751383 1.4338549990750589 0.6413259129875518 0.25557211156441145 0.3031141693911409 1.6358914338138952 0.1219123846934728 0.2964939522069931 1.7854362957694817e-07 6.748255640788673 0.7922710632999206 AVFVSEGK(ub)ILTTGFSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVFVSEGKILTTGFSR 16 1 P31146;H3BRY3;H3BTU6;H3BRJ0 P31146 CORO1A Coronin-1A;Coronin 1 37124500.0 6112500.0 12931000.0 18081000.0 True False 8013546.693534202 11001745.204643207 16210151.565198984 1.0 1.3728933798464116 2.022843590376566 22.934009471719918 -6.9626427763261765 0.39643268551139266 0.962834861801804 2.456498086607783 0.99985600821844 0.005071646550998213 0.07877022982579714 0.017739505647441048 0.008368962105882725 0.05452942490177317 1.0898261480813916e-07 6.9626427763261765 1.493663224805979 up AVGAFSATDSFDHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVGAFSATDSFDHK 14 0 B8ZZ19;P20472;H0Y3U0 B8ZZ19 PVALB Parvalbumin alpha 0 9853700.0 1360200.0 2945500.0 5548000.0 False True 1783235.372195536 2506042.8814690714 4973946.180173885 1.0 1.4053348876674692 2.7892819185444466 20.766065708567538 -6.948511998077751 0.5749465361504552 0.9831245755810697 3.2793529512996042 0.9990792875965057 0.02324365312652366 0.08408878965222366 0.03847786659145083 0.024488530878985983 0.11545388923457232 1.1258693645283605e-07 6.948511998077751 2.2962283757185347 up AVGAFSATDSFDHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVGAFSATDSFDHK 14 0 B8ZZ19;P20472;H0Y3U0 B8ZZ19 PVALB Parvalbumin alpha 0 7406500.0 1360200.0 2822200.0 3224100.0 False True 1863102.6980228678 2697505.8722326225 2462633.982423805 1.0 1.4478567794975696 1.321791860983918 20.82927577009043 -9.970725289308955 4.964544290474296 0.9999972186641108 1.3848243201627326 0.9255087485049343 0.05146578749665133 1.7021764564017275e-06 3.528414953670179e-07 0.04983192052468562 0.0166105114857834 1.0697313181819103e-10 9.970725289308955 0.38482710149862176 AVGAFSATDSFDHKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVGAFSATDSFDHKK 15 1 B8ZZ19;P20472;H0Y3U0 B8ZZ19 PVALB Parvalbumin alpha 0 22319000.0 0.0 11660000.0 10659000.0 False True 0.0 9920373.45032403 9556108.928347763 0.0 AVGAFSATDSFDHKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVGAFSATDSFDHKK 15 1 B8ZZ19;P20472;H0Y3U0 B8ZZ19 PVALB Parvalbumin alpha 0 28778900.0 10819000.0 3031900.0 14928000.0 False True 10475556.76702119 4242553.481149625 11017908.969599439 1.0 0.404995512458669 1.0517731147508707 23.32052358820052 -12.062325276425584 18.754318807161138 0.9154936681721008 0.7555458822442955 0.0 0.3002187817370658 0.0 0.0 0.0 0.08742365818592128 8.663127846653806e-13 12.062325276425584 -0.15994778592780523 AVGAFSATDSFDHKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVGAFSATDSFDHKK 15 1 B8ZZ19;P20472;H0Y3U0 B8ZZ19 PVALB Parvalbumin alpha 0 21147000.0 0.0 10351000.0 10796000.0 False True 0.0 9893658.593820387 8246207.150599366 0.0 AVGAFSATDSFDHKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVGAFSATDSFDHKK 15 1 B8ZZ19;P20472;H0Y3U0 B8ZZ19 PVALB Parvalbumin alpha 0 14343200.0 10819000.0 1890700.0 1633500.0 False True 8996477.862965925 1880514.423825436 1975057.2975493572 1.0 0.20902784983961215 0.2195367262203464 23.100928863634795 -10.29609333530715 5.597311981703891 1.000090215536262 0.2142822880299726 0.9998658522890458 0.004290230817175935 4.830501070663089e-06 6.074753257124833e-07 0.004154469370811716 0.0013846660421857973 5.0571596564759124e-11 10.29609333530715 -0.7858079275062895 AVGDGILCNTYIDSYK(ub)GTVDCVQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVGDGILCNTYIDSYKGTVDCVQAR 25 1 Q53EL6;Q53EL6-2 Q53EL6 PDCD4 Programmed cell death protein 4 1 17643700.0 3765600.0 5092500.0 8785600.0 True False 4874643.431073087 4809097.898332725 7186710.947868564 1.0 0.9865537790266778 1.474304951631407 22.216865262230225 -6.900562522920358 0.9577207065757128 0.9800323435656467 1.5260885424423145 0.9868433640188935 0.02601739393057535 0.1109925689667392 0.17510172367796523 0.020353102765505494 0.053105384442129484 1.2572958355671764e-07 6.900562522920358 0.5460561988766678 AVGEMCK(ub)GPGAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVGEMCKGPGAAR 13 1 A0A087X2B9;A0A087WTF2 A0A087X2B9 UQCRH 1 10087300.0 1471100.0 2444900.0 6171300.0 True False 1928626.3461526658 2080130.450145558 5532753.075289674 1.0 1.0785554466240292 2.868753237933686 20.879142230715853 -6.916095395779236 0.8531742565171339 0.9546738825277615 3.1330228653341 0.9930259671649099 0.07207130760779569 0.10052419696371462 0.11791856443868008 0.060845419022066326 0.17598217917949854 1.2131223505029044e-07 6.916095395779236 2.1783489828063383 up AVGEMCK(ub)GPGAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVGEMCKGPGAAR 13 1 A0A087X2B9;A0A087WTF2 A0A087X2B9 UQCRH 1 15607100.0 2715000.0 3426700.0 9465400.0 True False 2628813.811115866 4794999.180004425 6986127.784086718 1.0 1.8240162767438701 2.657520952813802 21.325980534295716 -6.970982785164234 0.233521653511409 0.6756038413075701 3.8298506442869322 0.9999890662946409 0.0022375255914606853 0.07598504830227593 0.007879810514572582 0.020871634850885785 0.08222796678640895 1.0690972559271495e-07 6.970982785164234 3.154246802979362 AVGEMCK(ub)GPGAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVGEMCKGPGAAR 13 1 A0A087X2B9;A0A087WTF2 A0A087X2B9 UQCRH 1 25198400.0 1961900.0 6262200.0 16974300.0 True False 2976345.7341022305 5144661.483208083 13619322.1649 1.0 1.7285160874497303 4.5758535404181 21.505110689823823 -6.945407100824895 0.6071788794484771 0.9683682175441697 5.483565466829491 0.9987897689747879 0.05367489696733154 0.0853841411884524 0.04401107641293656 0.05470600407542313 0.2398592342387283 1.1339473728690314e-07 6.945407100824895 4.515197249285322 AVGEMCK(ub)GPGAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVGEMCKGPGAAR 13 1 A0A087X2B9;A0A087WTF2 A0A087X2B9 UQCRH 1 11043200.0 1471100.0 1914200.0 7657900.0 True False 2015005.4249826816 1829624.3145870913 5849261.739401159 1.0 0.9079996966275247 2.9028516086756597 20.942352292238745 -6.896089612783347 0.985665907615154 0.9079305080185772 3.096377131475718 0.9845181284780049 0.11440550335545423 0.11434091938234563 0.194100284438111 0.0876534006634124 0.22389652441472707 1.270311960648562e-07 6.896089612783347 2.1884466234571405 up AVGEMCK(ub)GPGAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVGEMCKGPGAAR 13 1 A0A087X2B9;A0A087WTF2 A0A087X2B9 UQCRH 1 17951100.0 2715000.0 3599100.0 11637000.0 True False 2257642.794893475 3579710.933934584 14070242.896591278 1.0 1.5855966860796018 6.23227152161384 21.106385809729993 -6.930248072645841 0.7447525645251835 0.9299835541986702 7.192265285069588 0.9965867564806413 0.13675243279180607 0.09250936517111313 0.07705061208131589 0.12477203514678473 0.41987242730485286 1.174226635250577e-07 6.930248072645841 6.262281730870918 up AVGEMCK(ub)GPGAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVGEMCKGPGAAR 13 1 A0A087X2B9;A0A087WTF2 A0A087X2B9 UQCRH 1 13890600.0 1961900.0 7002400.0 4926300.0 True False 2539718.224830644 6612710.284395693 4029763.9481065455 1.0 2.603718089567455 1.5866972598408084 21.276237011916272 -10.498310231660422 5.037194631589108 0.9967462253592271 2.0952076747041652 0.60726134999132 0.4151970151021597 0.015194851803606541 0.0015133624058839888 0.4026281993301884 0.13400426040712435 3.174605529301964e-11 10.498310231660422 1.098461449344938 AVGHPFVIQLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVGHPFVIQLGR 12 0 O14980 O14980 XPO1 Exportin-1 0 65071000.0 25820000.0 27109000.0 12142000.0 False True 33850270.04123571 23064442.870054338 10885662.314288268 1.0 0.6813665841353025 0.32158273186676434 25.012664007187514 -7.191102113698781 0.30157259107817713 1.0706722460265556 2.658733524092155e-15 0.9999227340174508 0.0024360172648746512 0.08839571395130595 0.01591549160171325 0.009463286052246845 0.0394829441539784 6.440178227117617e-08 7.191102113698781 -1.070672246026553 down AVGHPFVIQLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVGHPFVIQLGR 12 0 O14980 O14980 XPO1 Exportin-1 0 54894000.0 18126000.0 9988000.0 26780000.0 False True 17550600.05167076 13976260.486731913 19765514.617220897 1.0 0.7963408912278995 1.1262016431933497 24.065017021053087 -6.739677474264627 1.6877699165046922 0.8787782188655633 1.1263851968946803 0.6035205967650226 0.08556974776034108 0.31840972118858846 1.7807811747965636 0.04010971463019336 0.09846457593180795 1.821052748548058e-07 6.739677474264627 0.24760697802911702 AVGHPFVIQLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVGHPFVIQLGR 12 0 O14980 O14980 XPO1 Exportin-1 0 52650000.0 0.0 52650000.0 0.0 False True 0.0 43254196.143672384 0.0 0.0 AVGHPFVIQLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVGHPFVIQLGR 12 0 O14980 O14980 XPO1 Exportin-1 0 97293000.0 25820000.0 31104000.0 40369000.0 False True 35366351.759263724 29729722.432826694 30834673.625652622 1.0 0.8406216913521313 0.8718646988397922 25.075874068710405 -10.22296785134417 5.383779581789524 1.0000094245060027 0.8562431950959456 0.9657869701258639 0.01275490439585044 1.4429462886759759e-06 2.0826318869094747e-07 0.01235069249057798 0.004116627692290571 5.984558941276217e-11 10.22296785134417 -0.14376622941005712 AVGHPFVIQLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVGHPFVIQLGR 12 0 O14980 O14980 XPO1 Exportin-1 0 52901000.0 18126000.0 13138000.0 21637000.0 False True 15072572.117951771 13067222.986311164 26161196.661815383 1.0 0.8669537544124807 1.7356823014073897 23.845422296487364 -6.867838431983907 1.1455492429831269 0.9256612408279666 1.784495032643605 0.9624735672080739 0.07400858534751026 0.1389399752278279 0.3421342831464644 0.050204138522156085 0.11842751684187265 1.355693669271808e-07 6.867838431983907 0.8588337918156385 AVGHPFVIQLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVGHPFVIQLGR 12 0 O14980 O14980 XPO1 Exportin-1 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 AVGIWHCGSCMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVGIWHCGSCMK 12 0 C9J4Z3;P61513;M0R0A1;Q6P4E4;E9PEL3;M0R2L6 C9J4Z3 RPL37A 60S ribosomal protein L37a 0 63608000.0 14779000.0 20186000.0 28643000.0 False True 19375412.120039597 17174327.4844117 25679297.12305706 1.0 0.8863980481038977 1.325354886077364 24.207723661422364 -6.838001091896718 1.2916818101860992 0.9395425566884815 1.339227417064297 0.9209571622038442 0.05229982141297547 0.17114603449867602 0.5555462642399428 0.031759689591015404 0.07313225490475943 1.4521079667149306e-07 6.838001091896718 0.3996848603758155 AVGIWHCGSCMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVGIWHCGSCMK 12 0 C9J4Z3;P61513;M0R0A1;Q6P4E4;E9PEL3;M0R2L6 C9J4Z3 RPL37A 60S ribosomal protein L37a 0 56582700.0 11568000.0 38433000.0 6581700.0 False True 17549501.734081585 31574330.871600438 5280824.110138411 1.0 1.799158252469486 0.300910201905215 24.064926734287003 -6.761756573587559 1.6055779004335193 1.4631510368912815 0.2948828965696826 0.6982951291715951 0.33621873595979185 0.27992619874234825 1.4225715223980218 0.1651853458893682 0.39632541411769734 1.7307862104122227e-07 6.761756573587559 -1.1682681403215989 AVGIWHCGSCMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVGIWHCGSCMK 12 0 C9J4Z3;P61513;M0R0A1;Q6P4E4;E9PEL3;M0R2L6 C9J4Z3 RPL37A 60S ribosomal protein L37a 0 47355000.0 14779000.0 14546000.0 18030000.0 False True 20243195.68745772 13903309.622810477 13771685.339506 1.0 0.6868139713446869 0.6803118219144945 24.270933722945255 AVGIWHCGSCMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AVGIWHCGSCMK 12 0 C9J4Z3;P61513;M0R0A1;Q6P4E4;E9PEL3;M0R2L6 C9J4Z3 RPL37A 60S ribosomal protein L37a 0 39997900.0 14853800.0 11405400.0 13738700.0 False True 19228536.912171587 10770679.463847635 11238397.570966324 1.0 0.5601403535299577 0.5844645186630119 24.19674565726601 -10.496988114722917 6.15372614473335 1.0003433518462923 0.5723024360964856 0.9975800216188122 0.009930298832530144 4.6814443829529805e-05 3.826660011454674e-06 0.009622460425091479 0.003204990166771001 3.184284664412168e-11 10.496988114722917 -0.42804091574980674 AVGK(ub)LSYNQLVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVGKLSYNQLVER 13 1 Q8N5J2-2;Q8N5J2-4;Q8N5J2;Q8N5J2-3 Q8N5J2-2 FAM63A Protein FAM63A 1 38299700.0 8846600.0 11627000.0 17826100.0 True False 11597978.270596253 9892296.921691028 15981626.172025533 1.0 0.8529328725136907 1.3779665558214498 23.46737000463428 -6.831948821864976 1.31934416449411 0.9215198769558242 1.3926488571285085 0.9096859699515948 0.06645928051777264 0.17841996733267948 0.6067283612564995 0.03954437825943504 0.09099321190729116 1.4724860129217343e-07 6.831948821864976 0.47112898017268434 AVGK(ub)LSYNQLVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVGKLSYNQLVER 13 1 Q8N5J2-2;Q8N5J2-4;Q8N5J2;Q8N5J2-3 Q8N5J2-2 FAM63A Protein FAM63A 1 67610400.0 10525000.0 19444200.0 37641200.0 True False 10190889.636093736 27208370.460163444 27781840.508205194 1.0 2.6698719573802263 2.7261447724650503 23.280776664445114 -10.628846822436074 0.633221437513814 7.878042954724855e-15 2.7183287305255086 0.9998937381703067 0.008254692536876185 2.1224625220887545 0.3134349347371101 3.366915735324749 0.009387595986511317 2.3504616927893017e-11 10.628846822436074 2.7183287305255006 AVGK(ub)LSYNQLVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVGKLSYNQLVER 13 1 Q8N5J2-2;Q8N5J2-4;Q8N5J2;Q8N5J2-3 Q8N5J2-2 FAM63A Protein FAM63A 1 83252300.0 11186000.0 25830600.0 46235700.0 True False 16969979.806140788 21220927.61460103 37097193.62917279 1.0 1.2504981064810687 2.186048189388459 24.016481512321466 -6.946452373835199 0.5965214740574969 0.9893765765666138 2.494775650265185 0.9988926588323592 0.016984952683272363 0.08494233805719206 0.04210455363627966 0.017492693889626813 0.07853343856197241 1.1312214360043283e-07 6.946452373835199 1.5053990736985712 up AVGK(ub)LSYNQLVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVGKLSYNQLVER 13 1 Q8N5J2-2;Q8N5J2-4;Q8N5J2;Q8N5J2-3 Q8N5J2-2 FAM63A Protein FAM63A 1 37226800.0 8846600.0 9033300.0 19346900.0 True False 12117427.09037575 8634178.936871573 14777560.681912834 1.0 0.7125422643334293 1.2195295727134923 23.53058006615717 -6.752883724222011 1.6390394172005682 0.8315586033193907 1.220770549568421 0.6613139956080365 0.12081353791007197 0.2950549297437365 1.5603575639417575 0.05820496509793026 0.1408881536886279 1.7665107139001069e-07 6.752883724222011 0.3892119462490302 AVGK(ub)LSYNQLVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVGKLSYNQLVER 13 1 Q8N5J2-2;Q8N5J2-4;Q8N5J2;Q8N5J2-3 Q8N5J2-2 FAM63A Protein FAM63A 1 44786800.0 10525000.0 16284400.0 17977400.0 True False 8752003.836557578 16196672.70499969 21736391.221893948 1.0 1.8506244978258968 2.4835902300567905 23.06118193987939 -7.355384552384626 0.13511621470181545 4.1775937894669524e-10 4.109437693015519 0.9999949639194637 0.0013640590914638555 0.11880386124578542 0.009103576428537008 0.0950091328064728 0.16829512246711145 4.4117962541396374e-08 7.355384552384626 4.10943769259776 AVGK(ub)LSYNQLVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVGKLSYNQLVER 13 1 Q8N5J2-2;Q8N5J2-4;Q8N5J2;Q8N5J2-3 Q8N5J2-2 FAM63A Protein FAM63A 1 60054800.0 11186000.0 31300800.0 17568000.0 True False 14480497.509024741 29558882.964385487 14370804.262902342 1.0 2.0412891854001134 0.9924247598499959 23.787607834413915 -6.647806953179152 2.0161010944450237 1.676845299434858 0.9968032644593393 0.18534158764922815 0.4446704624346095 0.5138999776625995 4.001173359819904 0.1790199756249937 0.4925643412192662 2.250054547972606e-07 6.647806953179152 -0.6800420349755186 AVGSISSTAFDIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVGSISSTAFDIR 13 0 I3L2B0;A0A494C0R8;K7EIG1;O75153 I3L2B0 CLUH Clustered mitochondria protein homolog 0 6643800.0 2034000.0 2165600.0 2444200.0 False True 2666593.6972840223 1842500.9214426824 2191297.630421958 1.0 0.6909567525488812 0.8217590976284979 21.34656659085046 -10.108229553252567 5.089651821275026 1.0000070461390176 0.756357925356431 0.8222560497902328 0.053399833769269336 4.2696499256831485e-06 7.481444228671647e-07 0.05170566183814987 0.017234722239619745 7.794180278370848e-11 10.108229553252567 -0.2436491207825866 AVGWWK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVGWWKR 7 1 H3BN98;H3BPJ2;Q15041-2;Q15041 H3BN98 ARL6IP1 ADP-ribosylation factor-like protein 6-interacting protein 1 1 7288950.0 970960.0 712790.0 5605200.0 True False 940137.4062766322 997410.7641507444 4137029.9676044206 1.0 1.0609201989961665 4.40045246576128 19.84251210448941 -6.91085434155909 0.8899021939513294 0.8993746722501132 4.840003558237577 0.9912398823987424 0.14870680481540763 0.10385560532043268 0.13572485342977325 0.12226492042482816 0.33953567904858994 1.2278509722172456e-07 6.91085434155909 3.940628885987464 up AVHQIQACLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVHQIQACLLR 11 0 Q6F5E8-2;Q6F5E8 Q6F5E8-2 RLTPR Leucine-rich repeat-containing protein 16C 0 11941200.0 4204500.0 3022800.0 4713900.0 False True 5512140.216435914 2571810.0227821157 4226150.846921719 1.0 0.46657195241760707 0.766698719731462 22.39418115674661 -10.171354461345127 5.555827288782797 1.0000095455417954 0.6166353360745014 0.6850861541489857 0.12252623967846202 1.448733506847648e-05 2.1609338546721906e-06 0.11863847368348511 0.03954517381232221 6.739777177655706e-11 10.171354461345127 -0.38337420946729406 AVHQIQACLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVHQIQACLLR 11 0 Q6F5E8-2;Q6F5E8 Q6F5E8-2 RLTPR Leucine-rich repeat-containing protein 16C 0 11202700.0 4204500.0 3554700.0 3443500.0 False True 5759017.272340205 3397641.600179051 2630216.2211086447 1.0 0.5899689894137794 0.4567126814745328 22.4573912182695 -13.999999999999998 0.15717739520951143 3.0077688950078234 0.32154801030069363 0.9995440788661155 0.004936459904040949 11.992063106790528 0.1251846229748913 7.342394562479709 0.12276893797196058 1.0000000000000041e-14 13.999999999999998 -2.68622088470713 AVIDLNNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVIDLNNR 8 0 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 0 6658400.0 2091100.0 804800.0 3762500.0 False True 2024719.1751102693 1126160.836976555 2776988.377419475 1.0 0.5562059424439552 1.3715424892285302 20.949290392002478 -6.758891690973295 1.6165661693156175 0.7418632674325009 1.374366040906814 0.6864409306322568 0.18663308063408798 0.28479153155039866 1.466562376283079 0.09110071050981039 0.21917623831071 1.7422413180856882e-07 6.758891690973295 0.632502773474313 AVIFCLSADKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVIFCLSADKK 11 1 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 124252000.0 37838000.0 45952000.0 40462000.0 False True 49605984.42371321 39096140.71949313 36275380.37891057 1.0 0.7881335523059181 0.7312702449176638 25.564010840823922 -13.999999999999998 0.1846060422028258 2.1153763988438814 0.6881855121852195 0.9994932982687285 0.002602870582459157 12.26777077342172 0.13623646235321954 4.913790358694354 0.04085069299940544 1.0000000000000041e-14 13.999999999999998 -1.427190886658662 AVIFCLSADKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVIFCLSADKK 11 1 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 27651500.0 21642400.0 4618500.0 1390600.0 False True 20955373.858450834 6462691.135159326 1026360.1428942244 1.0 0.3084025691363682 0.04897837422644294 24.320816924593057 -9.18965164678017 0.3675768681963031 1.2153791566069077 5.749672430020548e-24 0.9978400494892141 0.018654865469205497 0.6224597188280487 0.14511595109581613 0.2593082191626678 0.0705924900798652 6.461723243984858e-10 9.18965164678017 -1.2153791566069077 AVIFCLSADKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVIFCLSADKK 11 1 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 192094000.0 57388000.0 42446000.0 92260000.0 False True 87061791.62478149 34871179.6678883 74024770.56100541 1.0 0.4005336786334004 0.8502555389629131 26.375536373535507 -9.849825278496684 6.365330230416726 1.0000000178785413 0.6253946087981167 0.4805522731233234 0.18359818066400863 4.652557402342843e-08 8.739216880316893e-09 0.17776818197315233 0.05925605800876933 1.4131059385249596e-10 9.849825278496684 -0.3746054090804246 AVIFCLSADKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVIFCLSADKK 11 1 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 88075000.0 37838000.0 28631000.0 21606000.0 False True 51827731.133501895 27365987.749944136 16503107.789537776 1.0 0.5280182472092536 0.31842234704482414 25.627220902346814 -12.306354141783054 0.13036789667687873 2.479396108233963 1.7823086597963487e-23 0.9996964656483894 0.004966082428101439 6.282882741846011 0.09468085849288985 2.7384849657190187 0.2503752201647269 4.939077697940995e-13 12.306354141783054 -2.479396108233963 AVIFCLSADKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVIFCLSADKK 11 1 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 37779850.0 21642400.0 680650.0 15456800.0 False True 17996614.520884912 676983.2033515531 18688745.415831584 1.0 0.03761725309868254 1.0384589498287837 24.101222200027333 -12.059407647858245 18.347386574980753 0.8993233253364956 0.5842342913173642 0.0 0.4753845290524131 0.0 0.0 0.0 0.13730420979667116 8.721523436008098e-13 12.059407647858245 -0.31508903401913146 AVIFCLSADKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVIFCLSADKK 11 1 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 244059000.0 57388000.0 117974000.0 68697000.0 False True 74289897.28660025 111408643.19251943 56194850.890744604 1.0 1.4996472907038778 0.7564265525089174 26.146662695627956 -6.72556825581347 1.7391581315325617 1.3021594833398655 0.7571978681859309 0.5386701484374004 0.21012367341519858 0.34462862814951417 2.039952081335905 0.0958221653697213 0.23899946954399945 1.8811860267231062e-07 6.72556825581347 -0.5449616151539346 AVIHLLLCQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVIHLLLCQLR 11 0 B9ZVN9;O95602 B9ZVN9 POLR1A DNA-directed RNA polymerase;DNA-directed RNA polymerase I subunit RPA1 0 18968800.0 3848500.0 5370600.0 9749700.0 False True 5838455.863037085 4412174.46931068 7822667.521554687 1.0 0.7557091417345283 1.3398521295809611 22.47715542930224 -6.793134044963924 1.4840281312027523 0.8640199174859939 1.3465910642764485 0.8112457695453907 0.10406877170996334 0.23071307968016214 1.003721241650617 0.05519055297658505 0.12891243930831442 1.6101485862175107e-07 6.793134044963924 0.48257114679045454 AVIHLLLCQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVIHLLLCQLR 11 0 B9ZVN9;O95602 B9ZVN9 POLR1A DNA-directed RNA polymerase;DNA-directed RNA polymerase I subunit RPA1 0 13687400.0 3848500.0 4342800.0 5496100.0 False True 4981959.115276393 4101119.3623719886 4495866.194748262 1.0 0.8231941024559098 0.9024293637742624 22.24828175139469 -10.124144518325812 4.593109826729695 1.000013013730334 0.8628117331122064 0.7998804897933995 0.03234765998748904 4.311315736991225e-06 8.220893338168492e-07 0.03132345783103453 0.01044016236697674 7.513728212777913e-11 10.124144518325812 -0.13720128061812764 AVILELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVILELK 7 0 P52888;K7EP46 P52888 THOP1 Thimet oligopeptidase 0 5494300.0 1362100.0 1443700.0 2688500.0 False True 1785726.2905951648 1228305.587498523 2410319.8099130294 1.0 0.6878465047905752 1.34977001940745 20.768079535862675 -6.778481394114772 1.5419306353253261 0.8229014979240976 1.3547526083999133 0.7619298503236328 0.13192232394652845 0.2529422955153199 1.1877658577819756 0.0673954589816503 0.1592185658384196 1.665400174721398e-07 6.778481394114772 0.5318511104758157 AVILELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVILELK 7 0 P52888;K7EP46 P52888 THOP1 Thimet oligopeptidase 0 5757600.0 1745200.0 1006700.0 3005700.0 False True 1689799.5812741842 1408680.5598711474 2218417.000932818 1.0 0.8336376547146138 1.3128284712084215 20.68842071509313 -6.812945755421543 1.4021495880887918 0.9096439463999431 1.3217854859591247 0.8673654994094957 0.07234694476568296 0.2028153772121438 0.7853085889650209 0.04056485306763512 0.09371438668563915 1.538346772058068e-07 6.812945755421543 0.41214153955918165 AVILELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVILELK 7 0 P52888;K7EP46 P52888 THOP1 Thimet oligopeptidase 0 8439300.0 1362100.0 2108400.0 4968800.0 False True 1865705.1793684396 2015243.9164535694 3795271.77564822 1.0 1.0801513222661205 2.0342291041572595 20.831289597385567 -6.9235081273368655 0.7982568148495419 0.9814916894029003 2.2012339658211073 0.9951018401884923 0.03287907996389029 0.09615048731189287 0.09523156643962538 0.028868765780214824 0.08960482912667829 1.192591947618775e-07 6.9235081273368655 1.219742276418207 up AVIMFGVPYVYTQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVIMFGVPYVYTQSR 15 0 E7EVE9;A8MX75;P18074 E7EVE9 ERCC2 TFIIH basal transcription factor complex helicase XPD subunit 0 3080250.0 511820.0 819630.0 1748800.0 False True 701053.6854154286 783416.0364460446 1335769.457666559 1.0 1.1174836574488727 1.905373989832194 19.419165401863832 -6.9335278553464565 0.7172435877890404 0.9894444766666775 2.0826832807793774 0.9971873260144085 0.02131875278118627 0.09084684494705454 0.06900667464053307 0.019847392309986358 0.0699590447163656 1.1653923009871879e-07 6.9335278553464565 1.0932388041127 AVIQVSQIVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVIQVSQIVAR 11 0 J3QS36;Q7Z4W1;J3KS22;J3QL34;J3KSZ5;J3QS45;J3KRZ4 J3QS36 DCXR L-xylulose reductase 0 17232900.0 5551700.0 5638000.0 6043200.0 False True 7278332.462739273 4796832.376751869 5417907.6344677 1.0 0.6590565079719556 0.7443885893100046 22.79517652204132 -10.220395435210584 6.003067998919426 1.0000062316235356 0.7017225486409796 0.9421673421504508 0.03483667632798754 2.9055099535855136e-06 3.7729281428081424e-07 0.03373117124815241 0.011243488937958651 6.020111912801039e-11 10.220395435210584 -0.29828368298255603 AVIQVSQIVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVIQVSQIVAR 11 0 J3QS36;Q7Z4W1;J3KS22;J3QL34;J3KSZ5;J3QS45;J3KRZ4 J3QS36 DCXR L-xylulose reductase 0 14208000.0 6198400.0 2152200.0 5857400.0 False True 6001635.184832628 3011584.6835747333 4323171.2217665985 1.0 0.5017940262656467 0.7203322242398448 22.516924195319884 -10.302734701081759 5.731102275235804 1.0000392446426682 0.6110631252527434 0.8085467026364412 0.08921784572402966 4.474207786869063e-05 5.443499422879257e-06 0.08639350060130913 0.028794935889470987 4.980412321799057e-11 10.302734701081759 -0.3889761193899248 AVIQVSQIVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVIQVSQIVAR 11 0 J3QS36;Q7Z4W1;J3KS22;J3QL34;J3KSZ5;J3QS45;J3KRZ4 J3QS36 DCXR L-xylulose reductase 0 24790300.0 5430400.0 14110000.0 5249900.0 False True 8238313.815418108 11591960.258066814 4212254.963887084 1.0 1.4070792297778598 0.5113006202803049 22.973917651991187 -6.783135795259106 1.5233292332822461 1.2295692532756781 0.5034572302012351 0.7783786929274309 0.1723974833705728 0.24576370115196328 1.126570192425027 0.08911174727682863 0.20975062739572725 1.6476471244403984e-07 6.783135795259106 -0.726112023074443 AVIQVSQIVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVIQVSQIVAR 11 0 J3QS36;Q7Z4W1;J3KS22;J3QL34;J3KSZ5;J3QS45;J3KRZ4 J3QS36 DCXR L-xylulose reductase 0 19879300.0 5551700.0 5065100.0 9262500.0 False True 7604313.519051283 4841307.133954168 7074888.267175498 1.0 0.6366527526548079 0.9303782977188668 22.85838658356421 -9.92660126026411 6.4272854412091736 1.0000000273140848 0.7835155251868272 0.42004908865246005 0.11991295163800503 4.697103735460838e-08 7.806248467439958e-09 0.11610523174303107 0.03870173872404201 1.1841282430230516e-10 9.92660126026411 -0.21648450212725756 AVIQVSQIVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVIQVSQIVAR 11 0 J3QS36;Q7Z4W1;J3KS22;J3QL34;J3KSZ5;J3QS45;J3KRZ4 J3QS36 DCXR L-xylulose reductase 0 10277100.0 6198400.0 2133000.0 1945700.0 False True 5154244.235678717 2121509.10563265 2352536.874099649 1.0 0.4116043029057756 0.45642712423577353 22.29732947075416 -9.854479025003481 6.821330561350806 1.0000000086861325 0.434015715737152 0.9953181997254257 0.01829884018179063 2.411227447991853e-09 3.8704391608226813e-10 0.01771777634775424 0.005905925273241236 1.3980444346449374e-10 9.854479025003481 -0.5659842929489804 AVIVK(ub)NIDDGTSDRPYSHALVAGIDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVIVKNIDDGTSDRPYSHALVAGIDR 26 2 P61353 P61353 RPL27 60S ribosomal protein L27 1 34079400.0 5266400.0 5717000.0 23096000.0 True False 5099221.014681609 7999827.913761152 17046464.734851863 1.0 1.5688333356660074 3.34295467597343 22.281845439135115 -6.9505737416492614 0.5525078238414995 0.9758213232143802 4.019671797645577 0.9992455500824935 0.02740693166837475 0.08325614921036138 0.03501504767992379 0.029651895636746462 0.14724941108553802 1.120537146784125e-07 6.9505737416492614 3.0438504744311965 AVIVK(ub)NIDDGTSDRPYSHALVAGIDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVIVKNIDDGTSDRPYSHALVAGIDR 26 2 P61353 P61353 RPL27 60S ribosomal protein L27 1 26642200.0 5266400.0 6414800.0 14961000.0 True False 4379244.941078075 6380242.199161886 18089275.92815177 1.0 1.4569274578167826 4.130683752916224 22.06225071456939 -6.936368442534783 0.6925350957178904 0.9672849537892344 4.780663530438661 0.9976483192179615 0.06695963972955074 0.08946343363194104 0.06245379093496358 0.06350864963249031 0.234043105647985 1.1577947007622633e-07 6.936368442534783 3.813378576649426 up AVK(ub)DATNTGIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVKDATNTGIK 11 1 P50579;F8VQZ7;P50579-3;G3V1U3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 1 12734900.0 3726600.0 6637300.0 2371000.0 True False 4885608.688445735 5647040.711992759 2125671.664237973 1.0 1.1558520282944027 0.4350883993769496 22.22010688527346 -6.85009304476026 1.234513574664699 1.0831825610443144 0.4062042389676164 0.9404500905362261 0.07556198380028412 0.1573625876406599 0.4614359488172239 0.04789136148094901 0.11083868063601812 1.4122349500820628e-07 6.85009304476026 -0.6769783220766981 down AVK(ub)DATNTGIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVKDATNTGIK 11 1 P50579;F8VQZ7;P50579-3;G3V1U3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 1 18653800.0 3189900.0 8205500.0 7258400.0 True False 3088638.3705629786 11481998.941117203 5357207.2926675165 1.0 3.7174954020351474 1.734488356981409 21.55853953399747 -6.565072703854163 2.3261662234589586 2.866860377834597 1.7381352498046168 0.0 1.1850101418420191 0.7453887165688382 7.565034389760412 0.431900742213551 1.3305520046996784 2.722245547484946e-07 6.565072703854163 -1.1287251280299802 AVK(ub)DATNTGIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVKDATNTGIK 11 1 P50579;F8VQZ7;P50579-3;G3V1U3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 1 13384400.0 4582700.0 2897700.0 5904000.0 True False 6952290.94024686 2380582.795166561 4737071.812184873 1.0 0.34241702708172794 0.6813684658623723 22.72905702680281 -10.618070182996998 6.664086654857148 1.001390919081101 0.5118927464722702 0.7343953729744565 0.1383763454324648 0.002866446010803289 0.00016428062515095733 0.1343027981479934 0.04466077344741506 2.4095160138379236e-11 10.618070182996998 -0.4894981726088308 AVK(ub)DATNTGIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVKDATNTGIK 11 1 P50579;F8VQZ7;P50579-3;G3V1U3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 1 7951500.0 3726600.0 1941000.0 2283900.0 True False 5104424.727578314 1855240.2019713402 1744489.8583969886 1.0 0.36345725541759916 0.34176032589369276 22.28331694679635 AVK(ub)DATNTGIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVKDATNTGIK 11 1 P50579;F8VQZ7;P50579-3;G3V1U3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 1 14071800.0 3189900.0 9818300.0 1063600.0 True False 2652543.1865306385 9765406.86912004 1285993.8424692333 1.0 3.681526060992276 0.48481542129055144 21.338944809431748 -6.6842404711675005 1.8871910579983133 2.690154287729844 0.4966486973302748 0.3435126334336789 1.1354580755002142 0.42914537966438265 2.958629653608427 0.482187392783768 1.2646979994737197 2.068995417784838e-07 6.6842404711675005 -2.1935055903995693 AVK(ub)DATNTGIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVKDATNTGIK 11 1 P50579;F8VQZ7;P50579-3;G3V1U3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 1 8112200.0 4582700.0 2390300.0 1139200.0 True False 5932395.488522052 2257277.703757432 931877.2891790962 1.0 0.38050020571366044 0.15708279917987336 22.50018334889526 -10.770213352575178 0.21118895938266014 1.8936281344243406 4.5838309969868945e-17 0.9993208843693947 0.00929185440061113 2.662654408526807 0.11274431069064866 1.3228404213513028 0.12682073799401972 1.6974095740012813e-11 10.770213352575178 -1.8936281344243406 AVK(ub)NAIDDGCVVPGAGAVEVAMAEALIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVKNAIDDGCVVPGAGAVEVAMAEALIK 28 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 48291000.0 6315700.0 8946300.0 33029000.0 True False 9581378.639517546 7349762.867239069 26500803.672875006 1.0 0.7670882389435717 2.765865400995092 23.191801825838386 -6.877869968018669 1.09166416757105 0.8593525982403838 2.9018264199072985 0.9719238676762021 0.1495324456780614 0.12953102387283658 0.28386044674195965 0.10571429847945787 0.25430566810459265 1.3247381152658291e-07 6.877869968018669 2.0424738216669147 up AVK(ub)NAIDDGCVVPGAGAVEVAMAEALIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVKNAIDDGCVVPGAGAVEVAMAEALIK 28 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 40297600.0 6315700.0 7779900.0 26202000.0 True False 8175798.151059134 7346941.725918267 21433504.855223518 1.0 0.8986207328230709 2.6215795032130185 22.962928147930835 -6.892929840275891 1.0048692659753855 0.9138205937954177 2.7785759767609446 0.9827089472933508 0.10380263124738191 0.11679895965260698 0.20820977859830345 0.07838927170816876 0.19760789823106947 1.2795880032841585e-07 6.892929840275891 1.864755382965527 up AVK(ub)WSQQVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVKWSQQVER 10 1 Q5BJD5 Q5BJD5 TMEM41B Transmembrane protein 41B 1 13586300.0 1603700.0 5236700.0 6745900.0 True False 2432930.146174497 4302169.970476153 5412569.908167 1.0 1.7683080532504483 2.224712417936719 21.2142634678108 -9.02145634964308 0.15093492927754573 1.6973332579281851e-19 2.9935274440024946 0.9998333800275978 0.006523287271705188 0.49598560733585806 0.04994367002194958 0.5686734665409744 0.3447213783132402 9.51795506997686e-10 9.02145634964308 2.9935274440024946 AVK(ub)WSQQVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVKWSQQVER 10 1 Q5BJD5 Q5BJD5 TMEM41B Transmembrane protein 41B 1 12867100.0 1603700.0 3007300.0 8256100.0 True False 2076021.263653042 2839941.111370843 6753574.514739754 1.0 1.367973036255698 3.2531335940441766 20.985389789903248 -6.9392640086977595 0.6663741036896464 0.9785473225329089 3.750682579409445 0.9980659195185264 0.04340231732242481 0.088103984979167 0.056150493820737314 0.04201695770644566 0.1627851974225573 1.1501010271137749e-07 6.9392640086977595 2.7721352568765365 up AVKDYEQEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVKDYEQEK 9 1 Q9NVM9;Q9NVM9-2;H0YH12 Q9NVM9 ASUN Protein asunder homolog 1 5179440.0 1696500.0 936240.0 2546700.0 True False 1642645.536117151 1310085.5144270996 1879642.8706376574 1.0 0.7975460838154108 1.1442778306759445 20.64758976631497 -6.748414112597065 1.6556976833700212 0.8807341872001642 1.1448871711533781 0.6422165467431379 0.08506605272223752 0.30277312246217636 1.6325302732384175 0.04059512619124964 0.09871929105838444 1.784784918156561e-07 6.748414112597065 0.26415298395321396 AVLCPPPVK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVLCPPPVKK 10 1 P63000-2;P63000;P60763 P63000-2 RAC1;RAC3 Ras-related C3 botulinum toxin substrate 1;Ras-related C3 botulinum toxin substrate 3 1 14935800.0 8618600.0 6317200.0 0.0 True False 11156947.59800469 5965642.266734898 0.0 1.0 0.5347020064701025 0.0 23.411439041955408 -7.825474075102976 0.6150640238876667 1.0056054566113728 2.6771140694103753e-19 0.9882318856770925 0.044322698226797005 0.11588620170259313 0.15690502834475456 0.0436117078658936 0.07775387617917048 1.4946032589711303e-08 7.825474075102976 -1.0056054566113728 down AVLCPPPVKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVLCPPPVKK 10 1 P63000-2;P63000;P60763 P63000-2 RAC1;RAC3 Ras-related C3 botulinum toxin substrate 1;Ras-related C3 botulinum toxin substrate 3 1 46576700.0 29327000.0 15978800.0 1270900.0 True False 38447981.00307201 13594825.324874574 1139399.459333632 1.0 0.35359009680608045 0.029634832040792817 25.196404504964743 -8.626090231017566 0.4443607555815155 1.08691045357018 4.551305568092074e-18 0.9958280824356495 0.026054134572584018 0.2629029750580376 0.15423948741725596 0.1067231758475351 0.07029284880496847 2.365428194195967e-09 8.626090231017566 -1.08691045357018 AVLCPPPVKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVLCPPPVKK 10 1 P63000-2;P63000;P60763 P63000-2 RAC1;RAC3 Ras-related C3 botulinum toxin substrate 1;Ras-related C3 botulinum toxin substrate 3 1 16743100.0 4455900.0 9460200.0 2827000.0 True False 6759926.069925138 7771953.397120045 2268242.2108818856 1.0 1.1497098217830235 0.33554245821907414 22.688576037852993 -6.859244477851766 1.18956618841389 1.0810671448393894 0.2966850759798171 0.9527144798350257 0.0769419919826114 0.14758107295401862 0.3972635222661635 0.05046359151725843 0.11769725474479281 1.3827877456665744e-07 6.859244477851766 -0.7843820688595723 down AVLCPPPVKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVLCPPPVKK 10 1 P63000-2;P63000;P60763 P63000-2 RAC1;RAC3 Ras-related C3 botulinum toxin substrate 1;Ras-related C3 botulinum toxin substrate 3 1 35304500.0 29327000.0 4601600.0 1375900.0 True False 40169984.43237516 4398286.096543703 1050940.7575499883 1.0 0.10949185464455612 0.026162339179374397 25.259614566487635 -13.852626036973927 0.3364384376890465 9.999999993673761 0.012387791906635933 0.9997231107130296 0.007333996589909758 17.52195155420219 0.18548251710645272 111.45973915030164 0.026092294574882935 1.4040221619718738e-14 13.852626036973927 -9.987612201767124 AVLCPPPVKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVLCPPPVKK 10 1 P63000-2;P63000;P60763 P63000-2 RAC1;RAC3 Ras-related C3 botulinum toxin substrate 1;Ras-related C3 botulinum toxin substrate 3 1 13205700.0 10826700.0 1365400.0 1013600.0 True False 9002880.754133768 1358044.3191893215 1225539.0736431126 1.0 0.15084553003390175 0.1361274359965718 23.10195528017789 AVLCPPPVKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVLCPPPVKK 10 1 P63000-2;P63000;P60763 P63000-2 RAC1;RAC3 Ras-related C3 botulinum toxin substrate 1;Ras-related C3 botulinum toxin substrate 3 1 8844800.0 4455900.0 3284800.0 1104100.0 True False 5768250.388920367 3101997.992428734 903165.1290226815 1.0 0.5377710368445586 0.1565752295977785 22.459702359945442 -7.94514895865925 0.36287319381323857 1.0762559076641924 5.702996733246849e-20 0.9983705628458348 0.013920556849246746 0.10276836111318918 0.0717868648715851 0.04604693300099164 0.08373103580988424 1.134621585080884e-08 7.94514895865925 -1.0762559076641924 down AVLFCLSEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVLFCLSEDK 10 0 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 29420600.0 8429500.0 9352100.0 11639000.0 False True 11051156.131394122 7956803.134200277 10434707.929171568 1.0 0.7199973504669428 0.944218668626774 23.397693971183784 -9.925439215500095 5.9161869025543155 1.0000000737441506 0.8321080100168666 0.4277729234827127 0.09153796982458341 8.895268856598013e-08 1.6296276119809195e-08 0.08863129646941371 0.029543752722980026 1.1873008658053745e-10 9.925439215500095 -0.16789206372728394 AVLFCLSEDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVLFCLSEDK 10 0 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 13361800.0 5928400.0 3159300.0 4274100.0 False True 5740206.1870420985 4420824.965531857 3154584.989748462 1.0 0.7701509007657942 0.5495595257309049 22.45267112846915 -6.971625954676361 0.215846799737357 1.1072158155248566 0.20629552812467922 0.9999924383719565 0.0005056752587716707 0.07577855459319059 0.007111170706203823 0.006309134638556872 0.022559272785525324 1.0675151454446376e-07 6.971625954676361 -0.9009202874001774 AVLFCLSEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVLFCLSEDK 10 0 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 30722700.0 8429500.0 12893000.0 9400200.0 False True 11546113.94867209 12323344.628550494 7180066.363196014 1.0 1.0673153481191646 0.6218599950697514 23.460904032706676 -6.868402324016971 1.1425900693162299 1.0377229721329935 0.5965603981717774 0.9630584582049019 0.03768287050070749 0.13839189235998092 0.3386840254821032 0.025620417612100193 0.060491439758204375 1.3539345661476287e-07 6.868402324016971 -0.44116257396121605 AVLFCLSEDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVLFCLSEDK 10 0 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 7660800.0 5928400.0 1732400.0 0.0 False True 4929727.272650636 1723067.2173455239 0.0 1.0 0.34952587071192237 0.0 22.233076403903425 -8.500154349693947 0.5125425667532819 1.0508162072574034 7.48544897135228e-20 0.9934696079419426 0.033485180997280796 0.2219227189712812 0.18407276853353477 0.07949446381537068 0.06675115663034345 3.1611539759309293e-09 8.500154349693947 -1.0508162072574034 AVLFCLSEDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVLFCLSEDKK 11 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 610641800.0 97927500.0 174528000.0 338186300.0 False True 128383900.8312591 148489102.7048157 303194025.7880569 1.0 1.1566022043525674 2.361620295262401 26.935889060880683 -6.930827455148108 0.7399708009985478 0.9822267655548289 2.614297308750529 0.996698379595134 0.034954550592578924 0.09221031444856319 0.07559243727723337 0.03200352722938096 0.10854134275192212 1.1726611703594191e-07 6.930827455148108 1.6320705431956999 up AVLFCLSEDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVLFCLSEDKK 11 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 195085190.0 98629900.0 32545300.0 63909990.0 False True 95498947.81177762 45540808.01149737 47170046.36039729 1.0 0.4768723536227375 0.4939326290103893 26.508981502123348 -9.90576377199104 7.014857103868824 1.0000000108531562 0.4854024913405208 0.9991763543187557 0.006964828261860568 1.1868998595337885e-09 1.8622616582480895e-10 0.006743666117573653 0.0022478886556137286 1.2423278695688229e-10 9.90576377199104 -0.5145975195126353 AVLFCLSEDKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVLFCLSEDKK 11 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 905367800.0 64802000.0 631967800.0 208598000.0 False True 98309371.66078445 519188208.50304204 167368513.86824867 1.0 5.281166990818495 1.7024675373346108 26.550825616932812 -6.60211779696855 2.182609760834229 3.875180047016024 1.7142711761839768 0.026712130244374466 1.84944630828946 0.6347000545731585 5.717306673467435 0.7025499964413108 2.0565729498932486 2.499667266128563e-07 6.60211779696855 -2.160908870832047 AVLFCLSEDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVLFCLSEDKK 11 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 613789900.0 97927500.0 166503800.0 349358600.0 False True 134133943.14118119 159147111.5615642 266847293.94621915 1.0 1.1864790360636435 1.9894091510107326 26.999099122403575 -6.943186934191298 0.6292255695117472 0.9912413670672502 2.2278622849088765 0.9985521465139389 0.01633374944176892 0.08634252400990541 0.04821306398256513 0.016313606289609355 0.06819605916858602 1.139759093311669e-07 6.943186934191298 1.2366209178416263 AVLFCLSEDKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVLFCLSEDKK 11 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 204336760.0 98629900.0 22435000.0 83271860.0 False True 82015131.89541933 22314138.20200116 100683620.9204214 1.0 0.2720734294551252 1.2276224959170583 26.289386777557624 -6.703069666499762 1.8198698470095032 0.5493519095238376 1.2249536645497077 0.4321622850463125 0.30709804249052747 0.38918160024797605 2.5079449607107733 0.13451413399192702 0.34463683360652153 1.9812091885167553e-07 6.703069666499762 0.67560175502587 AVLFCLSEDKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVLFCLSEDKK 11 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 572972900.0 64802000.0 320629500.0 187541400.0 False True 83887466.43838914 302786186.46901804 153410789.53726518 1.0 3.609432962090926 1.8287688977940133 26.32195193902526 -9.313319645659279 8.833109627962711 0.9999954947857254 2.7191009299429516 0.5541152584531817 0.7269530601460624 0.0 0.0 0.7038692738521608 0.23462309128405356 4.860493361911911e-10 9.313319645659279 1.7191054351572261 AVLGEVK(ub)LCEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVLGEVKLCEK 11 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 36950800.0 8784600.0 10739400.0 17426800.0 True False 11516695.670187417 9137123.381853329 15623641.905669497 1.0 0.793380640030808 1.356608036983515 23.457223507375943 -6.807448694397741 1.425562042463281 0.887050477806472 1.365865660351065 0.8529691030356628 0.08920431246335082 0.21030764720217837 0.8428719131530978 0.049213225745217345 0.11396016190222737 1.557942072249676e-07 6.807448694397741 0.4788151825445931 AVLGEVK(ub)LCEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVLGEVKLCEK 11 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 29091200.0 10042600.0 7606500.0 11442100.0 True False 9723803.160041325 10643815.117373489 8445070.754357846 1.0 1.0946144160047204 0.8684946224602469 23.21308925836065 -6.793031532391109 1.4840408985215272 1.0526720514418386 0.8658793286628841 0.8110479465471625 0.04030481033975415 0.2308587671323588 1.004314388285671 0.021372915351442964 0.04993445032406917 1.6105286968644578e-07 6.793031532391109 -0.18679272277895453 AVLGEVK(ub)LCEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVLGEVKLCEK 11 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 224634500.0 26919500.0 79575000.0 118140000.0 True False 40838849.579063684 65374219.52768721 94789577.21739854 1.0 1.6007850417314828 2.32106384470715 25.283438890614413 -6.96871293784623 0.28726696750190034 0.8545816649058541 3.0894364700974073 0.9999705313538518 0.002931695332576701 0.07672255908118361 0.010517523042460177 0.012771723046264777 0.06552747483938472 1.0746995379370024e-07 6.96871293784623 2.2348548051915533 AVLGEVK(ub)LCEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVLGEVKLCEK 11 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 17465800.0 8784600.0 2524200.0 6157000.0 True False 12032504.014888767 2412672.4975868445 4702843.40739536 1.0 0.20051291855805362 0.39084494811521864 23.520433568898834 -10.805962592729216 10.550611058237525 1.006317677660799 0.2956789334645704 0.9480738828509313 0.07770272568723006 0.011382523788948534 0.00020933684327556227 0.07416294592167641 0.025078446878463764 1.563282287698389e-11 10.805962592729216 -0.7106387441962285 AVLGEVK(ub)LCEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVLGEVKLCEK 11 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 29336600.0 10042600.0 1437800.0 17856200.0 True False 8350866.862614074 1430054.286019045 21589848.86225943 1.0 0.171246208273448 2.5853422426017643 22.993494533794927 -6.814025195196485 1.3974856994887033 0.550437081886366 2.6316047197081667 0.8700962903701561 0.3609818431521889 0.20135912381415 0.7742453591076718 0.20306217969959792 0.46894095470911934 1.5345279559834202e-07 6.814025195196485 2.0811676378218005 AVLGEVK(ub)LCEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVLGEVKLCEK 11 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 171493500.0 26919500.0 73894000.0 70680000.0 True False 34847823.41267576 69781733.94195348 57816965.238042906 1.0 2.0024703728431614 1.6591270150035313 25.054565212706862 -10.200152750203872 4.539484213099877 0.9998059922603597 1.8307986939131724 0.8864513766517937 0.14016933891520802 98537488.16271585 71.71992327482087 200182.2676848505 0.047983692991294735 6.307354629693693e-11 10.200152750203872 0.8309927016528127 AVLGEVVLYSGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVLGEVVLYSGAR 13 0 P26640;A0A140T936;A0A140T954 P26640 VARS Valine--tRNA ligase 0 16944300.0 4762500.0 6301300.0 5880500.0 False True 6243683.620115605 5361170.6022750195 5272042.269739103 1.0 0.8586550710229219 0.8443801112461697 22.573966004261006 -13.999999999182418 0.3240442892062914 2.484618131981791 0.8416722687808916 0.9997023429376409 0.0012117750199131408 18.332471922039453 0.18172676255970777 18.49129323719768 0.004678709470979081 1.0000000018825531e-14 13.999999999182418 -1.6429458632008993 AVLGEVVLYSGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVLGEVVLYSGAR 13 0 P26640;A0A140T936;A0A140T954 P26640 VARS Valine--tRNA ligase 0 14683000.0 4466300.0 3591100.0 6625600.0 False True 4324519.751229014 5025044.957339106 4890156.596260596 1.0 1.1619891332236383 1.1307976093462933 22.0441084960642 -10.059139327424722 4.399776171268772 0.9999893843931754 1.146393371300366 0.9670730870798258 0.012733886351975343 8828025.538484097 0.5318012035287643 949.4128212373191 0.004359147992079319 8.726913525240071e-11 10.059139327424722 0.1464039869071906 AVLGEVVLYSGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVLGEVVLYSGAR 13 0 P26640;A0A140T936;A0A140T954 P26640 VARS Valine--tRNA ligase 0 27401300.0 4669600.0 16390000.0 6341700.0 False True 7084124.59348783 13465076.444345515 5088260.215334143 1.0 1.9007396420897869 0.718262383472418 22.75615815533076 -6.703094576202963 1.8196841287873897 1.5576368413300055 0.7215599791792328 0.43221294386496145 0.3800061575475512 0.38919048712716636 2.5074846350179545 0.16646036502033154 0.4264881753710258 1.981095556132204e-07 6.703094576202963 -0.8360768621507727 AVLGEVVLYSGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVLGEVVLYSGAR 13 0 P26640;A0A140T936;A0A140T954 P26640 VARS Valine--tRNA ligase 0 15918900.0 4762500.0 4836600.0 6319800.0 False True 6523324.951723212 4622903.019502625 4827193.400366602 1.0 0.7086728092981833 0.7399897193671829 22.637176065783898 -9.72560772748118 5.899444875548238 1.0000000083594986 0.7243312645292876 0.9904134866891992 0.012785075005712968 1.4035375196660548e-09 3.1267842132012824e-10 0.012379096009950297 0.004126365213674886 1.8810150593758194e-10 9.72560772748118 -0.275668743830211 AVLGEVVLYSGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVLGEVVLYSGAR 13 0 P26640;A0A140T936;A0A140T954 P26640 VARS Valine--tRNA ligase 0 10516200.0 4466300.0 2929600.0 3120300.0 False True 3713926.340638199 2913817.6633199267 3772740.3033628687 1.0 0.7845652810710344 1.0158360606351076 21.824513771498477 -11.119963214196739 11.745860237904342 3.5597571822718623 0.9002006708526465 0.19890161392427275 0.09441590039127777 0.03694467245155502 0.0003773253528785841 0.0005336462120967816 0.030472600819383088 7.5864183112369e-12 11.119963214196739 -2.6595565114192157 AVLGEVVLYSGARPLSHQPGPEAPALPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVLGEVVLYSGARPLSHQPGPEAPALPK 28 1 P26640;A0A140T936;A0A140T954 P26640 VARS Valine--tRNA ligase 0 46121400.0 6262400.0 22538000.0 17321000.0 False True 9500518.6427656 18515917.809802264 13897496.75793601 1.0 1.9489375797290454 1.4628145347115966 23.179574843075326 -10.23996970880595 4.928940026394373 0.9998733559683385 1.7058760572210798 0.7376205630065109 0.19845890208608555 0.00027624100255572255 4.259522776895387e-05 0.19219107486771733 0.06405233522346014 5.754800745514843e-11 10.23996970880595 0.7060027012527413 AVLGEVVLYSGARPLSHQPGPEAPALPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVLGEVVLYSGARPLSHQPGPEAPALPK 28 1 P26640;A0A140T936;A0A140T954 P26640 VARS Valine--tRNA ligase 0 28569400.0 6262400.0 10422000.0 11885000.0 False True 8106800.250359063 9842006.538325699 9722051.95039814 1.0 1.2140433012260023 1.199246515290362 22.950701165167775 -10.067419177024702 4.827341927801737 0.9999934936384092 1.2066449082607449 0.9961692820957968 0.006040762571416155 4.2301929278093236e-07 8.171153564404452e-08 0.005849127340713182 0.0019496477352010226 8.562110392908979e-11 10.067419177024702 0.20665141462233572 AVLHVALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVLHVALR 8 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ELR7;A0A2R8YF08;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 601740000.0 193330000.0 208680000.0 199730000.0 False True 253457502.2103835 177545757.42826906 179063855.54544526 1.0 0.7004951752459725 0.7064847320905598 27.917168626681963 -10.319965661833209 8.402488457499532 1.0000005728735044 0.7034899536683366 0.9996940564151038 0.002445226342438916 2.624288025829292e-08 2.1203617059380013e-09 0.0023675848115676753 0.0007891934084977958 4.786679374493531e-11 10.319965661833209 -0.29651061920516786 AVLHVALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVLHVALR 8 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ELR7;A0A2R8YF08;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 525579000.0 246640000.0 85939000.0 193000000.0 False True 238810548.2039101 120254890.86596456 142447510.12410855 1.0 0.5035577019959941 0.5964875136188654 27.831291320598528 -10.09699402930377 5.392749134533425 1.000006074434303 0.5500226078072242 0.9690033142337267 0.03793843672906876 2.7708079955944597e-06 4.639277979676488e-07 0.036734228845322583 0.012244577802605015 7.998452512328545e-11 10.09699402930377 -0.44998346662707867 AVLHVALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVLHVALR 8 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ELR7;A0A2R8YF08;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 893330000.0 248730000.0 318060000.0 326540000.0 False True 377341594.5987297 261299707.98587754 261999225.8724337 1.0 0.6924752312655785 0.6943290366678163 28.491295897184415 -9.925251713168663 6.0519271031478725 1.0000000959999134 0.6934021339666208 0.9999725801761471 0.0007568128865954949 9.802361505829948e-10 1.750139182157749e-10 0.0007327811556757987 0.0002442603087906919 1.1878135818402204e-10 9.925251713168663 -0.3065979620332926 AVLHVALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVLHVALR 8 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ELR7;A0A2R8YF08;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 764360000.0 193330000.0 255370000.0 315660000.0 False True 264809325.54680318 244086909.00433904 241107609.22176695 1.0 0.9217458958453425 0.9104951599567171 27.980378688204855 -13.999999999890594 0.2731817782177978 1.6144459159387503 0.9068742944395071 0.999590188199854 0.0008058253352695601 15.041403273289257 0.16548487776274115 5.142582195284457 0.004599521673927455 1.0000000002519163e-14 13.999999999890594 -0.7075716214992432 AVLHVALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVLHVALR 8 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ELR7;A0A2R8YF08;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 408591000.0 246640000.0 84377000.0 77574000.0 False True 205092088.0046135 83922444.35347676 93794364.73834926 1.0 0.4091939634043267 0.4573280502963107 27.611696596032804 -10.089445123432675 7.849604840230936 1.0000000403537204 0.4332610087131051 0.9946190696679057 0.019650658686691566 1.3881698092181889e-08 1.6253528129884006e-09 0.01902666987647778 0.0063422228196302445 8.138696932007241e-11 10.089445123432675 -0.5667390316406153 AVLHVALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVLHVALR 8 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ELR7;A0A2R8YF08;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 893860000.0 248730000.0 377810000.0 267320000.0 False True 321985888.2012978 356784541.3783189 218670502.93482786 1.0 1.10807508792207 0.679130704008122 28.262422219276864 -6.83995084341021 1.2826872521999617 1.0574926161393807 0.665041613519805 0.924360073847158 0.05009812297448864 0.1688559406944221 0.5396927935357033 0.03062676787061309 0.07055467696650759 1.4456033853303376e-07 6.83995084341021 -0.3924510026195758 AVLK(ub)FAAATGATPIAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVLKFAAATGATPIAGR 17 1 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 1 28520500.0 5327900.0 7586600.0 15606000.0 True False 5158768.73084501 10615968.943596354 11518320.430035427 1.0 2.0578493624112224 2.232765419617622 22.298595340811517 -10.716344428177406 0.3539000522841115 1.2599665072961667e-13 2.2623878261255412 0.9992607985126326 0.014806861340683198 2.3351191553629365 0.17230077320533585 2.0565434414388006 0.05128970801925647 1.921567177199798e-11 10.716344428177406 2.262387826125415 AVLK(ub)FAAATGATPIAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVLKFAAATGATPIAGR 17 1 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 1 6196100.0 1563700.0 0.0 4632400.0 True False 2141842.147403586 0.0 3538322.527272745 1.0 0.0 1.65199967306742 21.0304207274937 -6.742822279678449 1.6762366090021554 0.4069461365407755 1.6536026499377745 0.6175720032995439 0.4201434764196636 0.31274279553135004 1.7264191635521577 0.19819549889538185 0.4848792557218588 1.8079138022062794e-07 6.742822279678449 1.246656513396999 AVLK(ub)FAAATGATPIAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVLKFAAATGATPIAGR 17 1 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 1 23159000.0 5327900.0 13390000.0 4441100.0 True False 4430384.9159900285 13317865.412293112 5369713.476673674 1.0 3.0060289714843114 1.212019627751405 22.079000616245793 -6.619394814146166 2.1189627374992672 2.331657487377769 1.2188750865518778 0.08064221768965962 0.8628047253503243 0.5871551671306475 5.008748553787862 0.33467037305912123 0.956746258604141 2.402178003455616e-07 6.619394814146166 -1.1127824008258913 AVLLAVAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVLLAVAVK 9 0 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 0 28869500.0 8158500.0 10497000.0 10214000.0 False True 12377040.966243474 8623728.336564662 8195198.423044763 1.0 0.6967520233700922 0.6621290537371525 23.561163108522354 -13.999999999999998 0.30629283707039245 3.8686065812181214 0.6541529306137129 0.9996638177100732 0.0027827900674992257 17.01012407506271 0.17596241162116177 31.034260892310417 0.012183451320430597 1.0000000000000041e-14 13.999999999999998 -3.2144536506044084 AVLLAVAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVLLAVAVK 9 0 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 0 5276540.0 845540.0 1667100.0 2763900.0 False True 1158158.9878593266 1593442.009637519 2111123.744307299 1.0 1.3758404729757734 1.822827233944259 20.143401884181447 -6.96882701265064 0.28481097766621444 0.9070598105485761 2.3053188772400715 0.9999717332131761 0.0017881727427049804 0.07668515902230687 0.010385958766429674 0.008034197913269859 0.04078448147611696 1.0744172869641483e-07 6.96882701265064 1.3982590666914954 AVLLAVAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVLLAVAVK 9 0 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 0 28733100.0 8158500.0 12895000.0 7679600.0 False True 10561339.078077799 12177381.914384004 6281991.599350232 1.0 1.1530149561868182 0.5948101422469978 23.332289430614804 -6.833634654545292 1.3115639816146418 1.0815780057865945 0.5786395713017768 0.9129572008412784 0.06948258012238782 0.176366223201737 0.5920401514457974 0.04157852957819328 0.09568940223462184 1.4667812356700005e-07 6.833634654545292 -0.5029384344848177 AVLLLQEK(ub)CPHVTEHIPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVLLLQEKCPHVTEHIPR 18 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 21397000.0 3555200.0 5431800.0 12410000.0 True False 4660901.62860577 4621396.6129905665 11125932.245125791 1.0 0.9915241687632398 2.387077250642152 22.152177633494688 -6.905533136929099 0.9256312543648916 0.9504531454068822 2.5511978980128767 0.9891235603427879 0.06840198141011775 0.10744607475521983 0.15534373611280208 0.054793080692334385 0.14695580535028557 1.2429877915133216e-07 6.905533136929099 1.6007447526059946 up AVLLLQEK(ub)CPHVTEHIPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVLLLQEKCPHVTEHIPR 18 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 91079300.0 9548300.0 22378000.0 59153000.0 True False 14485469.17423333 18384471.05988798 47461383.62231913 1.0 1.269166420414616 3.276482318345834 23.78810307746175 -6.931427462851223 0.7349853400596585 0.9710336229880185 3.7039582462942753 0.9968113393397287 0.0573526806885159 0.09190349815496704 0.07409984988768469 0.0527017402848753 0.18022312958829045 1.1710421769147636e-07 6.931427462851223 2.732924623306257 up AVLLLQEK(ub)CPHVTEHIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVLLLQEKCPHVTEHIPR 18 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 23378800.0 3555200.0 7545600.0 12278000.0 True False 4869653.515667474 7212210.4420375815 9378189.27334744 1.0 1.481052074615419 1.9258432336457492 22.21538769501758 -6.972065586024982 0.2028709297948292 0.7448615575130781 2.6743528501364273 0.9999943275799212 0.0009004261466781095 0.075637989528479 0.0065737360283075015 0.014105428960314333 0.04688268276429693 1.0664350588154385e-07 6.972065586024982 1.9294912926233492 AVLLLQEK(ub)CPHVTEHIPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVLLLQEKCPHVTEHIPR 18 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 61612300.0 9548300.0 17435000.0 34629000.0 True False 12360462.575131495 16464726.92340326 28326877.32354538 1.0 1.3320477954060794 2.291732785190204 23.559229399554198 -6.952286217453413 0.533159302976812 0.9851994183972945 2.6823828900106985 0.9993686710804833 0.013761770928609989 0.08258059134278237 0.032262664774862976 0.015282744243835635 0.07939437721378925 1.1161274326717442e-07 6.952286217453413 1.697183471613404 up AVLQFTPASWTYVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVLQFTPASWTYVR 14 0 P48651;P48651-3;P48651-2 P48651 PTDSS1 Phosphatidylserine synthase 1 0 4967900.0 1648000.0 1992700.0 1327200.0 False True 2160543.959254702 1695396.9274837626 1189874.0754013658 1.0 0.7847083694925625 0.5507289357869963 21.042963154176178 -6.97006009689612 0.25674730741743784 1.0683543508421631 0.2601704276341874 0.9999828465806194 0.0007598377050020417 0.07628320406289896 0.00896037331818765 0.004988930154857343 0.022185782993670203 1.0713710405650531e-07 6.97006009689612 -0.8081839232079757 AVLQFTPASWTYVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVLQFTPASWTYVR 14 0 P48651;P48651-3;P48651-2 P48651 PTDSS1 Phosphatidylserine synthase 1 0 6983000.0 1648000.0 1665500.0 3669500.0 False True 2257310.1355254287 1591912.702928013 2802839.675724745 1.0 0.7052255150387066 1.2416723921156427 21.10617321569907 -6.757524720493951 1.6218580080169167 0.8282521073497859 1.2433913226047701 0.6807561676335472 0.12394255759673767 0.28709493419760684 1.487816822974451 0.060313783017062784 0.14529595335784287 1.747733776761108e-07 6.757524720493951 0.4151392152549842 AVLSLYASGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVLSLYASGR 10 0 K7EM38 K7EM38 ACTG1 0 38178000.0 16117000.0 0.0 22061000.0 False True 21129543.077250022 0.0 19778339.344054807 1.0 0.0 0.9360514456817552 24.332758233788557 -10.046338600863791 14.304511375304646 0.9999999978053848 0.46802572337865633 0.3010151378019492 0.38214140248580414 0.0 0.0 0.37000682193096623 0.12333560731032205 8.987965549887089e-11 10.046338600863791 -0.5319742744267285 AVLSLYASGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVLSLYASGR 10 0 K7EM38 K7EM38 ACTG1 0 73874000.0 16117000.0 0.0 57757000.0 False True 22075890.445548143 0.0 44115986.14275361 1.0 0.0 1.9983785592508276 24.395968295311448 -6.770630958232387 1.5718457230227412 0.42689488364512546 2.009939553453748 0.733041288362996 0.42152586936668784 0.2654083386393361 1.294190130477606 0.21136090858307896 0.5028755507753547 1.695778176009549e-07 6.770630958232387 1.5830446698086225 AVLVDLEPGTMDSVR ddPTM_RPMI8226_Bortezomib_1h_R1 2 AVLVDLEPGTMDSVR 15 0 P04350;M0QZL7;M0R278;M0R0X0;M0QY37;M0QX14;A0A075B724;P68371;Q3ZCM7;M0QY85 P04350;P68371;Q3ZCM7;M0QY85 TUBB4A;TUBB8;TUBB4B Tubulin beta-4A chain;Tubulin beta-4B chain;Tubulin beta-8 chain 0 62427300.0 16636900.0 21744800.0 24045600.0 False True 21811137.011968773 18500560.600566525 21557591.973682284 1.0 0.8482162388148045 0.988375432323984 24.37856164367081 -10.430479073297647 6.786749725394509 1.0000111441821076 0.9182958355721031 0.31181111504673764 0.05721975114291629 9.649791990622998e-06 8.097601302343788e-07 0.05541034070243932 0.018467595270887302 3.7112561194004046e-11 10.430479073297647 -0.08171530861000442 AVLVDLEPGTMDSVR ddPTM_RPMI8226_Bortezomib_2h_R1 2 AVLVDLEPGTMDSVR 15 0 P04350;M0QZL7;M0R278;M0R0X0;M0QY37;M0QX14;A0A075B724;P68371;Q3ZCM7;M0QY85 P04350;P68371;Q3ZCM7;M0QY85 TUBB4A;TUBB8;TUBB4B Tubulin beta-4A chain;Tubulin beta-4B chain;Tubulin beta-8 chain 0 53334700.0 17199900.0 9191900.0 26942900.0 False True 16653898.589249246 12862273.60512527 19885746.220325608 1.0 0.7723280849943677 1.1940595238860556 23.989356608294564 -6.7600901641213245 1.6122250162274017 0.8677698712792519 1.195602202994279 0.6913038146655057 0.0957602536227965 0.28276389888504705 1.448611248729522 0.046864615880927246 0.11260878043440144 1.7374400803921032e-07 6.7600901641213245 0.3278323317150271 AVLVDLEPGTMDSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AVLVDLEPGTMDSVR 15 0 P04350;M0QZL7;M0R278;M0R0X0;M0QY37;M0QX14;A0A075B724;P68371;Q3ZCM7;M0QY85 P04350;P68371;Q3ZCM7;M0QY85 TUBB4A;TUBB8;TUBB4B Tubulin beta-4A chain;Tubulin beta-4B chain;Tubulin beta-8 chain 0 67505000.0 16636900.0 28363400.0 22504700.0 False True 22788011.52531735 27110211.20277895 17189553.35884527 1.0 1.1896698916735085 0.7543244104360654 24.441771705193702 -6.788273926300039 1.5030766778741949 1.1062440267987332 0.7499020530945898 0.7957359906085436 0.08054692648041185 0.2379294401042413 1.061931775198913 0.0421831332211109 0.09889282441976086 1.628268696740862e-07 6.788273926300039 -0.35634197370414344 AVLVQFSNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVLVQFSNGK 10 0 E7EX70;Q9GZS1 E7EX70 POLR1E DNA-directed RNA polymerase I subunit RPA49 0 10150200.0 2091800.0 1906000.0 6152400.0 False True 2865194.988769474 1821786.617700866 4699329.832655384 1.0 0.6358333812678053 1.6401431145437062 21.450201893213293 -6.8085999933311765 1.420395862312189 0.8012027669994638 1.6571588222689055 0.85614793253861 0.15745196984582252 0.2087135303239778 0.8301797163386677 0.08716903180380423 0.20177216684625113 1.5538174937428715e-07 6.8085999933311765 0.8559560552694417 AVMHFLVNHVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVMHFLVNHVK 11 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 31592000.0 9253300.0 15687000.0 6651700.0 False True 12131165.909084678 13346560.747447073 5963445.891611868 1.0 1.1001878011949553 0.4915806062091704 23.532214876699822 -6.864636063471671 1.1620192198762351 1.05519007133349 0.45937935898518967 0.9590343840694284 0.05392812603916544 0.14210595071273055 0.36201096866848176 0.03612090676713643 0.0848116444011581 1.3657271294586727e-07 6.864636063471671 -0.5958107123483004 down AVMHFLVNHVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVMHFLVNHVK 11 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 30587600.0 12525000.0 3954600.0 14108000.0 False True 12127400.730838377 5533692.402966569 10412691.56907215 1.0 0.4562966562896797 0.8586086829467136 23.531767034573924 -9.899218965758015 6.039020217348405 1.0000000771048443 0.6574526696180634 0.49151226613255794 0.16424319711626068 1.704403433603546e-07 3.13918446678345e-08 0.15902782733487467 0.053009263929858795 1.2611914975395747e-10 9.899218965758015 -0.3425474074867809 AVMHFLVNHVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVMHFLVNHVK 11 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 21531100.0 4632400.0 5451700.0 11447000.0 False True 7027689.473803557 4478801.540673484 9184495.432601666 1.0 0.6373078317373985 1.3069011467905387 22.74461901501009 -6.759583702532158 1.6138519961844258 0.7892199510817447 1.3093125888601909 0.6893296691877151 0.15254124867524813 0.2836215352499462 1.455777375356363 0.074577412205278 0.17930826912648282 1.7394674143428907e-07 6.759583702532158 0.5200926377784462 AVMHFLVNHVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVMHFLVNHVK 11 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 34690300.0 9253300.0 12665000.0 12772000.0 False True 12674495.071030017 12105418.422445685 9755516.647596817 1.0 0.9551006453988794 0.7696966698022485 23.595424938222713 -6.944144248818553 0.6198120277955436 1.0020294482804317 0.7129486869933792 0.9986578600152469 0.0036519030234967763 0.08592587666575505 0.04637514582296209 0.0036783744392316652 0.01568968219996341 1.137249491149438e-07 6.944144248818553 -0.2890807612870525 AVMHFLVNHVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVMHFLVNHVK 11 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 23876700.0 12525000.0 6182100.0 5169600.0 False True 10415092.451580387 6148795.800249224 6250539.458470239 1.0 0.5903736168291243 0.6001424843350077 23.3121723100082 -10.665802455520307 6.620678965517189 1.002480638992089 0.5952580505820662 0.9995632786066222 0.003988123459044904 0.0001467130871584695 7.4057511965777306e-06 0.0038795964069325856 0.0012871613116250075 2.1587261104449155e-11 10.665802455520307 -0.4072225884100229 AVMHFLVNHVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVMHFLVNHVK 11 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 32947400.0 4632400.0 15874000.0 12441000.0 False True 5996733.118255517 14990597.945632549 10176865.65543988 1.0 2.4997940795459974 1.6970682961459498 22.51574533710254 -10.0542444217304 5.090859755362036 0.9999831708298338 2.0984311878504665 0.7140083897367218 0.32771142879996 6.259729381053498e-05 1.162943210511584e-05 0.3173100744291838 0.10576840883976506 8.825830412618139e-11 10.0542444217304 1.0984480170206328 AVMNFVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVMNFVVR 8 0 O60568;H7C2S8 O60568 PLOD3 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 0 8522000.0 2213900.0 3744600.0 2563500.0 False True 2902444.3394380966 3185920.276336475 2298253.610828364 1.0 1.097668001086718 0.7918338276465615 21.46883696992523 -6.82077981692621 1.3683984421075743 1.052601516524442 0.7850391929452782 0.8861932027389235 0.04302722831288052 0.19246600990029292 0.7079287298515969 0.024707263315633228 0.05693751715393269 1.5108459442069653e-07 6.82077981692621 -0.26756232357916376 AVMNFVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVMNFVVR 8 0 O60568;H7C2S8 O60568 PLOD3 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 0 6547800.0 3748400.0 1130100.0 1669300.0 False True 3629409.0937704216 1581354.8233936476 1232060.2520734447 1.0 0.4357058635544589 0.33946579739059274 21.79130325063581 -13.999999999999998 0.2488428159497998 4.901631463514842 0.3003409897528337 0.9995405276779143 0.006245304602264038 13.952373427879362 0.15785222339147362 27.19223176669229 0.04470170923032859 1.0000000000000041e-14 13.999999999999998 -4.601290473762008 AVMNFVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVMNFVVR 8 0 O60568;H7C2S8 O60568 PLOD3 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 0 9988100.0 2213900.0 1963300.0 5810900.0 False True 3032438.6583979037 1876554.914235105 4438485.099242112 1.0 0.6188269988704489 1.4636685516953045 21.532047031448123 -6.784028545653535 1.519957741337536 0.7852997919297393 1.4712522967909212 0.7814542444506336 0.16149529889456224 0.24436526714171752 1.1152579526263087 0.0836602443653976 0.19676700144409212 1.6442636441928868e-07 6.784028545653535 0.6859525048611819 AVMNFVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVMNFVVR 8 0 O60568;H7C2S8 O60568 PLOD3 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 0 6238800.0 3748400.0 1200200.0 1290200.0 False True 3116960.682275759 1193734.2843789516 1559974.854789213 1.0 0.3829802188930343 0.5004794778643927 21.571708526070086 -9.977367460879421 6.207859571836155 1.0000002503140404 0.44172984837970625 0.9678449996579322 0.047968871605948725 1.6620209180996213e-07 2.7425772189270608e-08 0.046445680978718706 0.015481886738832336 1.053495146466668e-10 9.977367460879421 -0.5582704019343341 AVNCTQK(ub)EAIGFATTVDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVNCTQKEAIGFATTVDR 18 1 Q8IWV8-4;Q8IWV8;Q8IWV8-2 Q8IWV8-4 UBR2 E3 ubiquitin-protein ligase UBR2 1 10761700.0 2774700.0 2455600.0 5531400.0 True False 3637658.570233022 2089234.0518538293 4959063.7889354415 1.0 0.5743348397098182 1.3632570768228456 21.794578707655084 -6.760187061429667 1.6120449752147683 0.7528045944881004 1.366138254667511 0.6916297351552547 0.1790388556247558 0.282600352954421 1.4475027001372724 0.08763299803327161 0.21053356938060014 1.737052475910359e-07 6.760187061429667 0.6133336601794105 AVNCTQK(ub)EAIGFATTVDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVNCTQKEAIGFATTVDR 18 1 Q8IWV8-4;Q8IWV8;Q8IWV8-2 Q8IWV8-4 UBR2 E3 ubiquitin-protein ligase UBR2 1 12055200.0 2774700.0 1681900.0 7598600.0 True False 3800581.5734480615 1607588.096700462 5803967.178079327 1.0 0.4229847631561252 1.5271260637128496 21.857788769177976 -6.764672642308168 1.5946508617995805 0.6667981447802093 1.5321545886925334 0.7098553873636564 0.24288685330172352 0.27512574220915414 1.3797977668688468 0.12011459658795304 0.28736521367937645 1.7192037812964105e-07 6.764672642308168 0.8653564439123241 AVNEK(ub)SCNCLLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVNEKSCNCLLLK 13 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 101631300.0 8832300.0 0.0 92799000.0 True False 13399244.827621784 0.0 74457236.97475332 1.0 0.0 5.55682338315544 23.67564835786878 -6.860336824672909 1.1839161030158556 0.4568890721347184 5.82779660367613 0.9540562504767107 0.5183963928497543 0.14646136592617987 0.3898779917007956 0.3414477967548589 0.7974074204413493 1.37931409851671e-07 6.860336824672909 5.370907531541412 up AVNEK(ub)SCNCLLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVNEKSCNCLLLK 13 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 74198000.0 8832300.0 14058000.0 51307700.0 True False 11433586.46066147 13275659.94202483 41970225.06145915 1.0 1.1611107317639324 3.6707838967118835 23.44677467996123 -6.919972135982953 0.8249473163777411 0.9445695201081454 4.075213334406005 0.9941728654205745 0.09334445109629336 0.09818816445004823 0.10570388646321575 0.0804137683924668 0.24080824671264375 1.2023415735007854e-07 6.919972135982953 3.1306438142978594 up AVNEQGK(ub)EVTEFGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVNEQGKEVTEFGNK 15 1 Q9H7Z7;X6RJ95;A6NHH0 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 4052500.0 1275600.0 1731600.0 1045300.0 True False 1672323.9529279713 1473252.0297239344 937142.3832256236 1.0 0.880960909006001 0.5603832807542088 20.673422914357857 -6.953848978701513 0.5148600287008943 1.0056720184050916 0.42149094422021155 0.9994697331303108 0.004275124037039547 0.08197606118384984 0.02984382611769137 0.00488378262268353 0.026467587398684943 1.1121183874195529e-07 6.953848978701513 -0.5841810741848801 AVNEQGK(ub)EVTEFGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVNEQGKEVTEFGNK 15 1 Q9H7Z7;X6RJ95;A6NHH0 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 7657500.0 2955100.0 1848000.0 2854400.0 True False 2861291.968039958 2585916.0371926897 2106747.009835522 1.0 0.9037581854899254 0.7362922181194553 21.448235288010014 -6.962673508211634 0.3959571569919008 1.0096265161913727 0.6243488177016198 0.9998568629022595 0.0013035751947374464 0.07875954515341307 0.017701195170446722 0.0021566404990544757 0.014052651033559203 1.0897490316804999e-07 6.962673508211634 -0.3852776984897529 AVNEQGK(ub)EVTEFGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVNEQGKEVTEFGNK 15 1 Q9H7Z7;X6RJ95;A6NHH0 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 4223000.0 1275600.0 1394300.0 1553100.0 True False 1747223.7917938323 1332695.2156664843 1186289.7670985437 1.0 0.7627501536584723 0.6789569674303764 20.73663297588075 -13.999999999999998 0.14502332398589063 2.1393290561759133 0.5812763794539078 0.9995836872544196 0.002774181343760797 11.942481123825738 0.11965540978129248 3.8410155093510716 0.08765307991916865 1.0000000000000041e-14 13.999999999999998 -1.5580526767220055 AVNEQGK(ub)EVTEFGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVNEQGKEVTEFGNK 15 1 Q9H7Z7;X6RJ95;A6NHH0 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 8461500.0 2955100.0 3515500.0 1990900.0 True False 2457296.5831269613 3496561.3037278894 2407187.9851184636 1.0 1.4229301126030307 0.9796082416943203 21.22864056344429 -6.656849650375069 1.9840290015409765 1.2729405960448303 0.9814646694458217 0.22227556270520843 0.1802111065855063 0.49198587684236345 3.7194871046505584 0.07346861882607093 0.1997153298525433 2.2036892323701453e-07 6.656849650375069 -0.2914759265990087 AVNEQGK(ub)EVTEFGNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVNEQGKEVTEFGNK 15 1 Q9H7Z7;X6RJ95;A6NHH0 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 23659000.0 6390500.0 8894000.0 8374500.0 True False 8272628.225587573 8399041.08154565 6850426.929626351 1.0 1.0152808578496344 0.8280834993210143 22.97991431778228 -6.88711697060974 1.0393316617461006 1.0107645326017607 0.8128662507854998 0.9789862092846361 0.012303378926552888 0.1215116224544954 0.23578430301100392 0.009052454276604179 0.022345023509416306 1.296829942532657e-07 6.88711697060974 -0.1978982818162609 AVNYFSK(ub)VK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVNYFSKVK 9 1 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 2654250.0 609060.0 1228200.0 816990.0 True False 798483.5581454304 1044957.347486102 732455.7119214599 1.0 1.3086773507436211 0.9173084460532566 19.60690317534036 -6.6964022286634615 1.8434019313521088 1.1923425462319968 0.9185358094009347 0.40068475837527173 0.1303835027726852 0.4030392229590646 2.6599948827701474 0.056477876801713255 0.14591080890378083 2.0118600708862404e-07 6.6964022286634615 -0.27380673683106205 AVNYFSK(ub)VK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVNYFSKVK 9 1 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 2595820.0 609060.0 581160.0 1405600.0 True False 834245.9412276202 555482.4295608784 1073626.229240687 1.0 0.6658497238158184 1.2869421068573745 19.67011323686325 -6.760576818928273 1.6101709999430522 0.8060395541195617 1.2892833299077682 0.6933016687394242 0.14055750972933115 0.2819839155476621 1.4410078564335815 0.0688685293765149 0.16541623652484458 1.7354942578183872e-07 6.760576818928273 0.48324377578820643 AVNYFSK(ub)VK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVNYFSKVK 9 1 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 3589980.0 635880.0 1801800.0 1152300.0 True False 528762.3942603547 1792093.3457707039 1393240.602366773 1.0 3.3892223902903047 2.6349086423130954 19.012260050028036 -10.019996881204955 5.5406832563899915 0.9999925225207307 3.0120655163031977 0.9046418635236584 0.30794729809036214 2.8445556136519895e-05 5.029537837738874e-06 0.2981697883356357 0.09938956308369598 9.549994441257034e-11 10.019996881204955 2.012072993782467 AVPETEDVQASVSDTAQQPSEEQSK(ub)SLEKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVPETEDVQASVSDTAQQPSEEQSKSLEKPK 31 2 Q6FIF0-2;Q6FIF0;H0YME2;H0YK21;H0YK54 Q6FIF0-2 ZFAND6 AN1-type zinc finger protein 6 1 46520000.0 12284000.0 23157000.0 11079000.0 True False 15901880.153840493 21868292.59336098 9062735.680139745 1.0 1.3752016982771391 0.5699159843027106 23.922694016404208 -6.779978449747277 1.535703756463656 1.212448369608346 0.5635109208303238 0.7674240962954111 0.15866921312799906 0.25059227583134847 1.1672858928253607 0.08137359525473478 0.19203110202920212 1.6596692603251001e-07 6.779978449747277 -0.6489374487780221 AVPLAGFGYGLPISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVPLAGFGYGLPISR 15 0 Q15118;Q15118-2 Q15118 PDK1 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial 0 2289220.0 639760.0 846160.0 803300.0 False True 838731.555444653 719916.2263058466 720182.2217977076 1.0 0.8583392643718805 0.8586564045702364 19.677849609775127 -10.002609061070507 5.015535632700575 1.0000014070621868 0.8584978344695543 0.9999962251576913 0.00012947194903454616 2.037144791314122e-09 4.048575885983565e-10 0.00012536191930798623 4.178689112066568e-05 9.94010424329377e-11 10.002609061070507 -0.14150357259263247 AVPLALALISVSNPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVPLALALISVSNPR 15 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 47246000.0 15531000.0 18916000.0 12799000.0 False True 20361291.402417935 16093806.53399051 11474682.256677285 1.0 0.7904118759421784 0.5635537564829827 24.279325730575042 -6.970113589298901 0.25545744085532684 1.067328952353803 0.2799456865184786 0.9999832545445055 0.0007292951280407627 0.0762658604284421 0.008898119968694601 0.004878347151461972 0.021553614693159733 1.071239087053576e-07 6.970113589298901 -0.7873832658353244 AVPLALALISVSNPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVPLALALISVSNPR 15 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 138595000.0 53658000.0 58184000.0 26753000.0 False True 51954656.160904296 81417174.6255516 19745586.72720349 1.0 1.5670813867654416 0.38005422778761405 25.630749713037474 -6.776784060920984 1.5482541372073302 1.3224369912890466 0.3715587726924097 0.7558901697347327 0.23950863676603426 0.25560644313786324 1.2099570053079336 0.12186686852925424 0.2883547846322215 1.6719217174207648e-07 6.776784060920984 -0.9508782185966369 down AVPLALALISVSNPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVPLALALISVSNPR 15 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 92116000.0 21083000.0 40643000.0 30390000.0 False True 31984452.373758804 33389939.104791597 24383403.179589793 1.0 1.0439428105445978 0.7623517481135558 24.93086744638305 -6.867021748025898 1.1496538574001485 1.0244592863232662 0.7467620545149511 0.961623599332385 0.024231466457435385 0.13974686158513436 0.347064918698559 0.01638466767914035 0.03860532440912919 1.3582454284621047e-07 6.867021748025898 -0.27769723180831507 AVPLALALISVSNPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVPLALALISVSNPR 15 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 87099000.0 15531000.0 20026000.0 51542000.0 False True 21273230.409493577 19141185.102873817 39368841.14081068 1.0 0.8997780184024945 1.850628248883235 24.342535792097934 -6.880849019260482 1.0750052774611638 0.9371516661799711 1.9191341415914642 0.974365855374811 0.06829818801148634 0.12688283542847306 0.2677382729349852 0.04890120906191451 0.11851959696687203 1.3156821443312025e-07 6.880849019260482 0.9819824754114931 AVPLALALISVSNPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVPLALALISVSNPR 15 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 73980000.0 53658000.0 10013000.0 10309000.0 False True 44619004.45244718 9959057.981575107 12464564.236569526 1.0 0.2232021557582935 0.27935549861614833 25.41115498847175 -10.294832112666205 8.489621683378205 1.0000007721675166 0.2512788271872222 0.995799083833925 0.02292450622555041 3.3506575684167483e-07 2.7817399227039904e-08 0.022196580855624867 0.007398852569298748 5.071867360301723e-11 10.294832112666205 -0.7487219449802944 AVPLALALISVSNPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVPLALALISVSNPR 15 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 75664000.0 21083000.0 33152000.0 21429000.0 False True 27292359.10806083 31307062.05704986 17529141.880107842 1.0 1.1470998873015446 0.6422728724440164 24.7019937684755 -6.828744666365079 1.3337078559185085 1.0786690610145082 0.6290521590609591 0.9033010731894915 0.06592132957833928 0.18236783799081266 0.6348984808625241 0.03881514399054999 0.08932099891805752 1.4833899544539168e-07 6.828744666365079 -0.4496169019535491 AVPYQK(ub)FEAHPNDLYVEGLPENIPFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVPYQKFEAHPNDLYVEGLPENIPFR 26 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 83112000.0 15783000.0 19584000.0 47745000.0 True False 23943964.89185767 16089082.189509619 38308179.82262314 1.0 0.6719472845109641 1.5999096221382338 24.51315873279183 -6.811132447190302 1.4096056586975882 0.8214544024124084 1.616595995636194 0.8628180382279542 0.14230767891175045 0.20524889309353014 0.8035505411192292 0.07937475851552349 0.18353164261173746 1.5447832537137244e-07 6.811132447190302 0.7951415932237855 AVPYQK(ub)FEAHPNDLYVEGLPENIPFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVPYQKFEAHPNDLYVEGLPENIPFR 26 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 20563700.0 7703300.0 8130200.0 4730200.0 True False 6405635.264052631 8086400.998881653 5719262.950026301 1.0 1.2623886102696482 0.8928486737485447 22.610910222928002 -6.7160049466829435 1.7737875796618419 1.1603106286228002 0.8935529537785865 0.493587589062054 0.11047134271661796 0.36312212369670144 2.2305894223057536 0.0494949574074328 0.12483395216755457 1.9230698247154845e-07 6.7160049466829435 -0.26675767484421375 AVPYQK(ub)FEAHPNDLYVEGLPENIPFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVPYQKFEAHPNDLYVEGLPENIPFR 26 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 123782000.0 15783000.0 19192000.0 88807000.0 True False 20431404.62944192 18123948.328876104 72645037.23676957 1.0 0.8870632566671044 3.555557660097785 24.28428505488428 -6.8970181711929905 0.9799370016784578 0.8797955769320158 3.8192902190018816 0.9850231862947517 0.15079439696805919 0.11363319073069399 0.19006136585363026 0.11602969772122385 0.2976136914382914 1.267598827503064e-07 6.8970181711929905 2.9394946420698655 up AVQFFVQALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVQFFVQALR 10 0 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EK03;K7EIH8;K7EPP7 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 0 20110500.0 5929600.0 8148200.0 6032700.0 False True 7773763.022328087 6932520.321434841 5408494.073744589 1.0 0.8917843651167396 0.6957369369519131 22.890181698132864 -6.961932711132594 0.4072882937803011 1.0099477621992414 0.5703301406849947 0.9998352824538677 0.0016161817387453541 0.07901791418974492 0.01863316792104638 0.0025229515174853027 0.016383140325674343 1.0916094555071597e-07 6.961932711132594 -0.43961762151424677 AVQFFVQALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVQFFVQALR 10 0 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EK03;K7EIH8;K7EPP7 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 0 18108300.0 7590100.0 5820500.0 4697700.0 False True 7349156.430110687 8144656.0035065245 3467231.442020858 1.0 1.1082436577532282 0.4717863165648574 22.809147229621406 -6.863122122825922 1.1699465483440616 1.0592836778200796 0.4390895286807583 0.9573186216637912 0.05744358358265162 0.14361532707388075 0.3717899265271647 0.03824537949740325 0.08960843215327143 1.3704963308762714e-07 6.863122122825922 -0.6201941491393212 down AVQFFVQALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVQFFVQALR 10 0 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EK03;K7EIH8;K7EPP7 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 0 115850000.0 26040000.0 42005000.0 47805000.0 False True 39504583.779001005 34508879.56343704 38356320.796324186 1.0 0.8735411504773409 0.9709334241033774 25.23551672538888 -10.151299148576907 4.995659074080072 1.0000044766208633 0.9222372873571846 0.4594672351790894 0.03976022921278642 1.9825494034780576e-06 3.367827658170697e-07 0.03849989246399153 0.012832558798461326 7.058311996222678e-11 10.151299148576907 -0.07776718926367876 AVQFFVQALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVQFFVQALR 10 0 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EK03;K7EIH8;K7EPP7 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 0 27948100.0 5929600.0 9390500.0 12628000.0 False True 8121933.3614147995 8975596.659769135 9645526.481823718 1.0 1.1051059224900648 1.1875899558160763 22.953391759655755 -6.973846923584156 0.13823563763891267 0.886685928476328 1.4081584008519965 0.9999989768430108 7.743752263261893e-05 0.0750730279400842 0.004179656826348091 0.004749419975191986 0.010829141896738238 1.0620698405541008e-07 6.973846923584156 0.5214724723756685 AVQFFVQALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVQFFVQALR 10 0 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EK03;K7EIH8;K7EPP7 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 0 20636500.0 7590100.0 7775800.0 5270600.0 False True 6311504.448442338 7733910.222024551 6372658.09149901 1.0 1.2253671506059476 1.009689233930868 22.589552505055682 -10.79872801498661 2.5664979372137156 0.9642585757174175 1.1175281915881103 0.2836283750256883 0.0880501461232546 33402222.607018016 20654341.43257468 7401904.696683978 0.03360748824172337 1.589541917194304e-11 10.79872801498661 0.15326961587069288 AVQFFVQALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVQFFVQALR 10 0 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EK03;K7EIH8;K7EPP7 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 0 114460000.0 26040000.0 53939000.0 34481000.0 False True 33709293.32513888 50937247.23380834 28205811.80493716 1.0 1.5110743124306798 0.8367369654676958 25.00664304748133 -6.7040603443870035 1.8165447843595628 1.3160937032078246 0.838595268006716 0.43675365505886743 0.2155759601486821 0.38715813635539037 2.4865035704919656 0.09457922855119112 0.242007148200999 1.976694963047734e-07 6.7040603443870035 -0.4774984352011086 AVQFTEEK(ub)FGQAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVQFTEEKFGQAEK 14 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9 Q9NR46 SH3GLB2 Endophilin-B2 1 13678500.0 3942000.0 6365200.0 3371300.0 True False 5168000.174382309 5415536.971355275 3022470.215793116 1.0 1.047897985414165 0.5848432882753082 22.301174688036447 -6.881379764473194 1.0721217595290389 1.0302606356400814 0.5511524062058263 0.9747794445269756 0.03301941368031202 0.1264127320980771 0.2649858885202417 0.023695145811784453 0.05750483505308193 1.314075249664211e-07 6.881379764473194 -0.47910822943425513 AVQFTEEK(ub)FGQAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVQFTEEKFGQAEK 14 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9 Q9NR46 SH3GLB2 Endophilin-B2 1 12978780.0 6082380.0 6896400.0 0.0 True False 5889298.17622648 9650168.484250888 0.0 1.0 1.6385939708751773 0.0 22.489664288608132 -6.815596417203853 1.488053906388509 1.3509566792675802 2.1345283469353584e-21 0.8345682005369808 0.2742825026634522 0.21079610772449667 0.9340728656477968 0.14701495081190907 0.3246812251887995 1.5289862603059284e-07 6.815596417203853 -1.3509566792675802 AVQFTEEK(ub)FGQAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVQFTEEKFGQAEK 14 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9 Q9NR46 SH3GLB2 Endophilin-B2 1 57600700.0 14447300.0 10019000.0 33134400.0 True False 21917610.339107618 8231031.1711957045 26585371.316676572 1.0 0.37554418770321263 1.212968517340609 24.385587175107876 -6.70705629582551 1.8055501018358606 0.6149528607020316 1.210848071463535 0.45117566914935536 0.26326641448312466 0.38102499995573774 2.4194392027707914 0.11611168211437739 0.29605235951088704 1.963105790931292e-07 6.70705629582551 0.5958952107615034 AVQFTEEK(ub)FGQAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVQFTEEKFGQAEK 14 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9 Q9NR46 SH3GLB2 Endophilin-B2 1 12584000.0 3942000.0 3261900.0 5380100.0 True False 5399463.928544448 3117778.4723391645 4109431.1866376163 1.0 0.5774237060566186 0.7610813297433047 22.36438474955934 -10.236129558185512 5.523624546331507 1.0000199601143074 0.6692525178999447 0.8121812122714472 0.07497791090080515 1.8430936268755638e-05 2.5488528121773257e-06 0.07260142669660512 0.024199016687678106 5.80591190447913e-11 10.236129558185512 -0.3307674422143627 AVQFTEEK(ub)FGQAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVQFTEEKFGQAEK 14 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9 Q9NR46 SH3GLB2 Endophilin-B2 1 18175280.0 6082380.0 7827100.0 4265800.0 True False 5057768.465121234 7784933.858742298 5157759.057169292 1.0 1.539203289440355 1.0197697053033568 22.27006956404241 -10.567522446988946 2.8577277188362085 0.9837948123924145 1.2794864968050177 0.27850527079614473 0.21205787891836153 66972682.66970274 71393689.148419 8307348.90039316 0.07556751006879003 2.7069332894751157e-11 10.567522446988946 0.2956916844126032 AVQFTEEK(ub)FGQAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVQFTEEKFGQAEK 14 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9 Q9NR46 SH3GLB2 Endophilin-B2 1 63209600.0 14447300.0 14600300.0 34162000.0 True False 18702314.648858678 13787780.470304806 27944866.53172073 1.0 0.7372232116277765 1.49419294116229 24.156713497200325 -6.812929703415229 1.402032562785898 0.8572778913611141 1.5083630613662558 0.8673863131907488 0.11427698013292377 0.20282354516358178 0.7851835530259206 0.06407820208524283 0.14804968012112873 1.5384036321138226e-07 6.812929703415229 0.6510851700051417 AVQFTEEK(ub)LGQAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVQFTEEKLGQAEK 14 1 A0A087WW40;Q9Y371;Q9Y371-2 A0A087WW40 SH3GLB1 Endophilin-B1 1 4252000.0 1959200.0 1025200.0 1267600.0 True False 1897006.2684118617 1434567.7063473735 935577.532815131 1.0 0.7562271829224723 0.4931863159305104 20.85529301528061 -6.970154563752569 0.25446818407268973 1.0790197799789496 0.16264544793783461 0.9999835623265028 0.0008390487507092962 0.07625259572286672 0.008850558612290314 0.005693589969070408 0.025030048490984256 1.0711380234489865e-07 6.970154563752569 -0.916374332041115 down AVQGFFTSNNATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVQGFFTSNNATR 13 0 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 31810600.0 22592000.0 9218600.0 0.0 False True 30944872.92584371 8811291.770166416 0.0 1.0 0.2847415722559855 0.0 24.88319706178703 -8.842345973579189 0.48393941529987466 1.08951243119215 4.070414242231685e-23 0.9954674661254261 0.028321254722063212 0.4043238314133187 0.1945769431848915 0.13577195196547623 0.05886255036669901 1.4376528393837653e-09 8.842345973579189 -1.08951243119215 AVQHCLALLNLTLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVQHCLALLNLTLQK 15 0 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 0 29945900.0 5914900.0 12315000.0 11716000.0 False True 8973335.73711264 10117292.032465827 9400327.464694776 1.0 1.127483951215814 1.0475845036997946 23.097212959908152 -10.292213967743661 3.6521498715058764 0.9997730446449168 1.087534227443525 0.6154320216272335 0.032618813012069744 11568811.553240405 8.220718467197791 22145.598802695302 0.011166287281660236 5.1025354686263006e-11 10.292213967743661 0.08776118279860812 AVQHCLALLNLTLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVQHCLALLNLTLQK 15 0 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 0 9708000.0 1505800.0 3017000.0 5185200.0 False True 2062534.9527149193 2883698.964115168 3960562.552546118 1.0 1.3981333796643536 1.9202402108787637 20.975987137497757 -6.967393959067214 0.31426326080823314 0.9235091373820266 2.4115638437875266 0.9999543314225874 0.002546495565659938 0.07715770327831044 0.012042551685442158 0.008106539973133969 0.04616565770069891 1.0779684272508602e-07 6.967393959067214 1.4880547064055 AVQHCLALLNLTLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVQHCLALLNLTLQK 15 0 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 0 17950700.0 5914900.0 5674400.0 6361400.0 False True 7656954.650109987 5358614.651801521 5203690.473476034 1.0 0.6998362791301824 0.6796031465853446 22.8683392820006 -13.99999997350489 0.3831612125978086 5.5436555496603 0.6779230205234463 0.999812563782462 0.002005692287531471 24.43946625361208 0.20218374789718283 91.71570093183117 0.00543254909113889 1.0000000610072474e-14 13.99999997350489 -4.865732529136853 AVQIVSHPFFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVQIVSHPFFGR 12 0 Q9BZQ6;Q9BZQ6-2;H0Y498 Q9BZQ6 EDEM3 ER degradation-enhancing alpha-mannosidase-like protein 3 0 3963600.0 1611200.0 2352400.0 0.0 False True 2206904.1810428216 2248463.1896534683 0.0 1.0 1.0188313606760258 0.0 21.073592561635273 -7.00968506760252 1.1072907718564566 1.0280418769400115 7.653391512900042e-21 0.9844408578087225 0.0593626508978377 0.09008791982168314 0.2154891371236366 0.045173502086743374 0.08240557746263648 9.779461299782565e-08 7.00968506760252 -1.0280418769400115 down AVQK(ub)LYEHIVADDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVQKLYEHIVADDR 14 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 26076300.0 4670700.0 6387100.0 15018500.0 True False 6123332.931123139 5434169.576720796 13464529.687624631 1.0 0.8874529015236907 2.1988890427937213 22.54588569517644 -6.886021209459376 1.0456096066707623 0.9226685926158843 2.3032788105136484 0.9782279203627454 0.08756875802077167 0.1224317482643258 0.2411692508325602 0.06412109312442262 0.15773179949994803 1.300106083741628e-07 6.886021209459376 1.3806102178977642 up AVQK(ub)LYEHIVADDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVQKLYEHIVADDR 14 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 40434600.0 4809000.0 11818600.0 23807000.0 True False 4656340.92731351 16537828.61318481 17571232.5053091 1.0 3.5516790697553926 3.773613826736453 22.150765262479695 -10.178133115557102 0.5352349943057865 1.0675799780762513e-20 3.7593670264161796 0.999504762058608 0.028005460283459488 1.4793945345178496 0.2512614493696759 2.314798097712609 0.0422873310726165 6.635396577570673e-11 10.178133115557102 3.7593670264161796 AVQK(ub)LYEHIVADDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVQKLYEHIVADDR 14 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 44455700.0 11307700.0 6387700.0 26760300.0 True False 17154607.603602532 5247765.027672109 21471114.975543868 1.0 0.3059099426191514 1.251623789461372 24.032092790118107 -6.70995734448627 1.794987460726025 0.5732895061187183 1.249440418468286 0.4651229498358569 0.2924853058057983 0.3751317681527768 2.35598439944648 0.12966196918547676 0.32946493655711356 1.9500361189027026e-07 6.70995734448627 0.6761509123495676 AVQK(ub)LYEHIVADDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVQKLYEHIVADDR 14 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 28510000.0 4670700.0 6299600.0 17539700.0 True False 6397584.01092149 6021262.842008587 13397184.101460509 1.0 0.9411776120062706 2.094100535231708 22.609095756699332 -6.894882139935442 0.9930722781554795 0.945105642316053 2.2032848682771555 0.9838429815892505 0.06739038321733312 0.11527057445726252 0.19943235959683536 0.051346419118137226 0.1304722992685542 1.2738487347840136e-07 6.894882139935442 1.2581792259611024 up AVQK(ub)LYEHIVADDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVQKLYEHIVADDR 14 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 35586600.0 4809000.0 10636900.0 20140700.0 True False 3998896.574822359 10579596.908440668 24352027.249924906 1.0 2.645629040533673 6.089686690885894 21.93117053791397 -6.959147568666397 0.44728525761279375 0.8858024246166293 7.985429509989969 0.9997372662380751 0.03437380705260192 0.08000704255379448 0.022267102188910586 0.04585163245643421 0.28499947641911233 1.0986324723218595e-07 6.959147568666397 7.09962708537334 AVQK(ub)LYEHIVADDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVQKLYEHIVADDR 14 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 43755600.0 11307700.0 18154000.0 14293900.0 True False 14638040.558090366 17143713.94135144 11692556.867799388 1.0 1.171175463909765 0.7987788270839962 23.803219112210556 -6.781717811593269 1.5291499025336406 1.0967068789668208 0.7956666410635403 0.7734377301981434 0.07244269300279989 0.24791038840376511 1.1450923154747201 0.03730886101483762 0.0879087112925651 1.653035530381347e-07 6.781717811593269 -0.3010402379032805 AVQK(ub)TSDLIVLGLPWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVQKTSDLIVLGLPWK 16 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 15064600.0 3127800.0 8147000.0 3789800.0 True False 4100576.089658288 6931499.356757274 3397667.8503285856 1.0 1.6903720855805153 0.8285830517564479 21.967395177422766 -6.693410641506223 1.8541925465519078 1.431441020417023 0.8314302772480141 0.3863649567498527 0.29178234086862426 0.4094440486106076 2.731792873428124 0.1257625571548078 0.32610607463192404 2.0257663765931823e-07 6.693410641506223 -0.6000107431690088 AVQK(ub)TSDLIVLGLPWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVQKTSDLIVLGLPWK 16 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 28374500.0 9599800.0 8550700.0 10224000.0 True False 9295059.603664842 11965039.101311423 7546027.686574546 1.0 1.2872471626318422 0.8118320923514368 23.148032685640096 -6.743131418029442 1.6752812883016548 1.1702900269499366 0.8113619624827924 0.6188783065565787 0.12068419479983342 0.31218868965122865 1.721540058118852 0.056962892774605825 0.13930155133642583 1.8066273556906881e-07 6.743131418029442 -0.3589280644671442 AVQK(ub)TSDLIVLGLPWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVQKTSDLIVLGLPWK 16 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 63405000.0 7529000.0 10871000.0 45005000.0 True False 11422043.443629 8930985.114489323 36109742.02360776 1.0 0.7819078222356839 3.161408219275255 23.445317441205155 -6.884497948504417 1.054428596499477 0.8547789373491871 3.345266132454883 0.9771348331268325 0.16240194046688447 0.12371894594418158 0.2488593697952555 0.11812525614836858 0.2892093439201429 1.3046741315708286e-07 6.884497948504417 2.490487195105696 up AVQK(ub)TSDLIVLGLPWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVQKTSDLIVLGLPWK 16 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 19968800.0 3127800.0 9797800.0 7043200.0 True False 4284232.18561677 9364900.799008155 5379741.219257266 1.0 2.185899454854116 1.2557072040395925 22.030605238945657 -10.439412232326937 5.153344861698782 0.9990690751425467 1.7208033294468736 0.44463598407705185 0.37974939619784137 0.004066396533793768 0.00044234661634968774 0.36812023176386766 0.12256359060053533 3.63569771859311e-11 10.439412232326937 0.7217342543043269 AVQK(ub)TSDLIVLGLPWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVQKTSDLIVLGLPWK 16 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 23775300.0 9599800.0 8757500.0 5418000.0 True False 7982659.043248007 8710321.609272346 6550878.749998417 1.0 1.0911554110080424 0.8206386762239787 22.928437961074373 -6.815841890089522 1.3900332187561575 1.0493475914952586 0.8152560141087208 0.8744843759086561 0.039813443094014016 0.19894629681083506 0.7564631520283576 0.02251522669688718 0.051953640628833474 1.528122287508292e-07 6.815841890089522 -0.23409157738653774 AVQK(ub)TSDLIVLGLPWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVQKTSDLIVLGLPWK 16 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 75757900.0 7529000.0 8315900.0 59913000.0 True False 9746438.918777695 7853112.854736391 49009448.759293534 1.0 0.8057417606759345 5.028446714509327 23.216443763297605 -6.896118835270991 0.9854965680074249 0.8052550923519538 5.438325626943307 0.9845338789544217 0.24206377486562974 0.1143181744116298 0.19397715318717404 0.18548536674889043 0.4738485248669012 1.2702264877074107e-07 6.896118835270991 4.633070534591353 up AVQSGHVNLK(ub)DR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVQSGHVNLKDR 12 1 Q15545;A0A096LPC3 Q15545 TAF7 Transcription initiation factor TFIID subunit 7 1 5593600.0 1434700.0 2092100.0 2066800.0 True False 1389156.2338150747 2927486.440157375 1525443.0773290568 1.0 2.107384589937408 1.0981076427521002 20.405777432916253 -6.624005634876544 2.1016360599794326 1.7326828754989174 1.1020077489085354 0.09658307625417362 0.47572316940497894 0.5747300560886968 4.829008849275555 0.18561962720077996 0.5274221585768996 2.3768094478386364e-07 6.624005634876544 -0.630675126590382 AVQSGHVNLK(ub)DR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVQSGHVNLKDR 12 1 Q15545;A0A096LPC3 Q15545 TAF7 Transcription initiation factor TFIID subunit 7 1 4905300.0 1434700.0 2348300.0 1122300.0 True False 1193016.6179866164 2335649.2417989452 1356967.7410711006 1.0 1.9577675671783032 1.137425682603797 20.18618270835053 -10.196535215935517 4.260349615342955 0.9998086172734633 1.5475966249217759 0.3726926695482744 0.3349031721887621 235349712.34573376 182.50354649409732 477290.2317195755 0.11464626370918912 6.360112300659604e-11 10.196535215935517 0.5477880076483126 AVQSGHVNLK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVQSGHVNLKDR 12 1 Q15545;A0A096LPC3 Q15545 TAF7 Transcription initiation factor TFIID subunit 7 1 4132740.0 349740.0 2133700.0 1649300.0 True False 452745.3244060712 2014957.7193269592 1349144.323247088 1.0 4.450532364901302 2.979918842932166 18.788340216681267 -10.550317626988825 10.251105284795667 0.9999333094088095 3.715225603916734 0.8196640131648147 0.6003754562769404 0.0009151040643302986 4.0141179819777985e-05 0.5813238682958134 0.19377034530268913 2.816322423372332e-11 10.550317626988825 2.7152922945079245 AVQSLDK(ub)NGVDLLMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVQSLDKNGVDLLMK 15 1 O15511;B1ALC0;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 13438400.0 3186400.0 2651300.0 7600700.0 True False 3085249.4761471776 3709977.9163468494 5609848.653887634 1.0 1.202488792245036 1.8182804007451434 21.556955721080815 -6.951144271319792 0.5461374900565068 0.9912822254899035 2.058224943222753 0.999288045139087 0.00928485382856163 0.08302950233009321 0.034085837552970656 0.010128328178585597 0.05104900526045743 1.1190660713322924e-07 6.951144271319792 1.0669427177328492 AVQSLDK(ub)NGVDLLMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVQSLDKNGVDLLMK 15 1 O15511;B1ALC0;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 35307200.0 2875800.0 6050400.0 26381000.0 True False 3722779.790492875 5713689.921270945 21579928.691918615 1.0 1.5347912696481263 5.796724465687925 21.82794884988109 -6.930167342760236 0.7454173621812487 0.9355889318712093 6.675416904416597 0.9965710079358553 0.12568096897443087 0.09255114558630063 0.0772552890752594 0.11461531680404181 0.38527763073513277 1.1744449295118462e-07 6.930167342760236 5.739827972545387 up AVSGALLSLHFLFVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVSGALLSLHFLFVR 15 0 P55160;P55160-2;F8W050 P55160 NCKAP1L Nck-associated protein 1-like 0 19592800.0 4736800.0 8303700.0 6552300.0 False True 7186071.90646591 6821839.85789577 5257235.033024886 1.0 0.949314165887707 0.7315867558038921 22.776771940871146 -6.9432400137253225 0.6287006844101856 1.0023751322924113 0.6668176119289546 0.9985582029407377 0.004421258033772583 0.0863191820575957 0.048108899916689 0.004417849813474753 0.018488625479897422 1.139619800303781e-07 6.9432400137253225 -0.33555752036345665 AVSGALLSLHFLFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVSGALLSLHFLFVR 15 0 P55160;P55160-2;F8W050 P55160 NCKAP1L Nck-associated protein 1-like 0 15531200.0 4736800.0 5966400.0 4828000.0 False True 6131880.976287179 5634364.595112885 3949353.539463373 1.0 0.9188639859289087 0.6440688517497425 22.547898262963596 -6.948697942325283 0.572969444700245 1.0033787524089368 0.5461256611297876 0.9990950282688278 0.004581870930336252 0.08401304188821694 0.03816041801170032 0.004837930308901386 0.022912747609162797 1.1253874239781255e-07 6.948697942325283 -0.45725309127914926 AVSILPLLGHGVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVSILPLLGHGVPR 14 0 Q9Y2W2 Q9Y2W2 WBP11 WW domain-binding protein 11 0 7232800.0 1956300.0 2811500.0 2465000.0 False True 2564728.244836151 2392035.1591411675 2209945.4459496466 1.0 0.9326661270866863 0.8616684634713921 21.290374537223734 -6.970455673378621 0.24706985049999672 1.0233592708074049 0.7689036249883463 0.9999857087589605 0.00021343836754764492 0.07615517684761954 0.00849987128043952 0.0016154794851788988 0.0068375162251576435 1.0703956281411415e-07 6.970455673378621 -0.25445564581905855 AVSILPLLGHGVPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVSILPLLGHGVPR 14 0 Q9Y2W2 Q9Y2W2 WBP11 WW domain-binding protein 11 0 8262300.0 2878700.0 1668200.0 3715400.0 False True 2787317.2442207136 2334320.959548073 2742225.2803891855 1.0 0.8374794668199705 0.9838224500906659 21.41044578440196 -10.332434105834496 6.507346656889543 1.000004045826082 0.9106509584607251 0.3320066893761566 0.05974427274164315 3.506946238787693e-06 3.5980499422149397e-07 0.057849762826097356 0.019282381113304808 4.651209421825642e-11 10.332434105834496 -0.08935308736535685 AVSILPLLGHGVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVSILPLLGHGVPR 14 0 Q9Y2W2 Q9Y2W2 WBP11 WW domain-binding protein 11 0 9531000.0 1956300.0 4636000.0 2938700.0 False True 2679596.97701966 4431166.190798116 2244639.5844263025 1.0 1.6536689020027973 0.8376780551987589 21.353584598746625 -6.693424187136272 1.8542502346129586 1.408500554844737 0.840384298370673 0.3863865121618669 0.2762694801257966 0.40941398787894306 2.7317987242986375 0.1190750106037713 0.308747732522462 2.0257031939944627e-07 6.693424187136272 -0.5681162564740639 AVSILPLLGHGVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVSILPLLGHGVPR 14 0 Q9Y2W2 Q9Y2W2 WBP11 WW domain-binding protein 11 0 5262100.0 2878700.0 1314600.0 1068800.0 False True 2393766.5980330906 1307517.9888723318 1292281.138427151 1.0 0.5462178267282586 0.5398526069705343 21.190851059836238 AVSTCAHLFWSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVSTCAHLFWSGR 13 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 17217340.0 6657600.0 9881600.0 678140.0 False True 8728178.072290104 8407303.798175124 607972.5779782111 1.0 0.9632369697939964 0.06965629859321729 23.057249105150355 -6.981437706583758 0.9323949621139602 1.0174307108103617 1.0322766075267243e-21 0.9922489169983946 0.03787182724009687 0.08705083947807524 0.13349600157360683 0.031651048789345916 0.07335548287297117 1.0436678214175321e-07 6.981437706583758 -1.0174307108103617 down AVSTCAHLFWSGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVSTCAHLFWSGR 13 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 59719000.0 12839000.0 20457000.0 26423000.0 False True 19477701.65662804 16806288.518729478 21200482.468387663 1.0 0.8628476200635556 1.088448875649216 24.215320115543093 -6.742145741224605 1.678716077317057 0.9185971459798861 1.0886466271627757 0.6145406772597528 0.05762390000069534 0.31397232040433865 1.7380900980318745 0.02714567902790195 0.06646000341070332 1.810732342245941e-07 6.742145741224605 0.17004948118288965 AVSTCAHLFWSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVSTCAHLFWSGR 13 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 25773600.0 6657600.0 7934000.0 11182000.0 False True 9119094.63487505 7583449.645770548 8541041.900518913 1.0 0.8316011566289065 0.9366107319310589 23.120459166673246 -10.322791286154938 5.165646672253271 1.0000367992513954 0.8841059442870685 0.6189117923112837 0.042869979599487455 1.817430749138869e-05 2.3826345488047053e-06 0.04152185128209808 0.01383622642008206 4.755637181057587e-11 10.322791286154938 -0.11593085496432698 AVSTCAHLFWSGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVSTCAHLFWSGR 13 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 58350000.0 12839000.0 25980000.0 19531000.0 False True 16620338.594526047 24534190.161744576 15976558.404983232 1.0 1.476154653661808 0.9612655189976186 23.986446437635543 -6.663729789515457 1.9598186739837764 1.305554802032572 0.9634036278726114 0.2514883745275853 0.20255768998012597 0.4756777321083969 3.5160451657125016 0.0833931772589017 0.22462563185460593 2.1690532323270023e-07 6.663729789515457 -0.34215117415996066 AVSTGVQAGIPMPCFTTALSFYDGYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVSTGVQAGIPMPCFTTALSFYDGYR 26 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 169708000.0 60030000.0 56809000.0 52869000.0 False True 91069898.78085385 46670990.09925709 42419418.97669411 1.0 0.5124743820300479 0.4657896796258676 26.440470944850144 -13.999999999999998 0.33177573861254533 6.364186150069009 0.4576927462176535 0.999718515779624 0.004053076385634515 18.974340355953743 0.18428640670865526 71.08746808283924 0.014861764637324098 1.0000000000000041e-14 13.999999999999998 -5.906493403851355 AVSTGVQAGIPMPCFTTALSFYDGYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVSTGVQAGIPMPCFTTALSFYDGYR 26 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 109779000.0 60030000.0 13727000.0 36022000.0 False True 77710018.36820623 12963080.382997219 29466365.616932385 1.0 0.16681350301032546 0.379183614103842 26.211597266942594 -10.776212325285554 7.767280145508847 1.013283536374373 0.2729985585570837 0.9398499448111606 0.08669973479954879 0.019222467232470834 0.0005538291409750539 0.08091148278295605 0.02798221908327101 1.674124201556631e-11 10.776212325285554 -0.7402849778172893 AVTDFVIPECQKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVTDFVIPECQKK 13 1 Q6P0N0 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 5826300.0 1471200.0 2400200.0 1954900.0 True False 1928757.4471210646 2042099.515906323 1752625.7007249326 1.0 1.0587642935374983 0.9086812358604069 20.879240296517533 -6.800525475408083 1.453921438505898 1.0324018843573008 0.9065864085330053 0.8336355088475554 0.02518636555174671 0.22002005904383673 0.9181871969838337 0.013628019749842303 0.03168145161309841 1.5829767076854436e-07 6.800525475408083 -0.12581547582429553 AVTEQGAELSNEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVTEQGAELSNEER 14 0 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 53677010.0 5022500.0 24196000.0 24458510.0 False True 6584546.137959181 20586051.115269303 21927778.00779468 1.0 3.126419146278434 3.3301882238144644 22.650652570613612 -10.271117756045811 0.5011232219893795 1.539569235599009e-20 3.323234727905862 0.9994687606228665 0.024286832635026633 1.603106993420325 0.23472570949120863 2.2619437363681674 0.041225200383067005 5.356513995248416e-11 10.271117756045811 3.323234727905862 AVTEQGAELSNEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVTEQGAELSNEER 14 0 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 59681700.0 13930000.0 4979700.0 40772000.0 False True 13487799.774896491 6968120.178792445 30092590.0662184 1.0 0.5166239338577311 2.231097033500361 23.685151689092606 -6.831422363868866 1.3216573356016712 0.7419688915697122 2.2785489543467503 0.9086698818560391 0.21812759148620264 0.179062314574565 0.6112347427589051 0.12956829325153144 0.29814852148002563 1.4742720638926934e-07 6.831422363868866 1.536580062777038 up AVTEQGAELSNEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVTEQGAELSNEER 14 0 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 164130000.0 0.0 164130000.0 0.0 False True 0.0 134839719.146457 0.0 0.0 AVTEQGAELSNEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVTEQGAELSNEER 14 0 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 54800500.0 5022500.0 25143000.0 24635000.0 False True 6879453.977959014 24032099.12321765 18816720.373750973 1.0 3.4933149055453754 2.73520550236074 22.713862632136504 -9.94569408030029 5.572382162730474 0.9999971805612454 3.114260203956579 0.9120516689915139 0.30949686784712155 1.0841097414498387e-05 2.0514560650649653e-06 0.2996694462643948 0.09988968457113508 1.1331983140123087e-10 9.94569408030029 2.1142630233953335 AVTEQGAELSNEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVTEQGAELSNEER 14 0 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 17882900.0 13930000.0 2498500.0 1454400.0 False True 11583412.203633912 2485040.0845865817 1758508.315614191 1.0 0.21453437388742694 0.1518126338508887 23.465556964526883 -13.841644538697745 0.3596168798383656 9.999999998712914 0.1441503583192424 0.9997683477496663 0.005873537721506518 19.261356094463412 0.1934368041180903 132.36798704061653 0.01813048416371906 1.4399766880299365e-14 13.841644538697745 -9.855849640393672 AVTEQGAELSNEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVTEQGAELSNEER 14 0 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 10309600.0 0.0 5810800.0 4498800.0 False True 0.0 5487423.871896286 3680064.5615861285 0.0 AVTGTHTLALAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVTGTHTLALAAK 13 0 P49770;H0YK01 P49770 EIF2B2 Translation initiation factor eIF-2B subunit beta 0 6515600.0 3367900.0 1734600.0 1413100.0 False True 4613103.644075293 1657959.63644487 1079354.8837080358 1.0 0.35940220822357255 0.23397585811761984 22.13730627558287 -13.999999999999972 0.22926636237179682 5.03022296924047 0.1725652439221213 0.9995088007986375 0.007435131320187532 13.268532072598552 0.15161376729534007 24.33274106659428 0.06540593674399037 1.0000000000000655e-14 13.999999999999972 -4.857657725318349 AVTGVLASHPNSTDVHIINLSLTFHGQELLSDTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVTGVLASHPNSTDVHIINLSLTFHGQELLSDTK 34 0 Q9UG63;Q9UG63-2;C9JHK9;C9JZV3 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 0 148530000.0 98689000.0 35975000.0 13866000.0 False True 149718428.13232836 29554980.176042058 11125379.022316307 1.0 0.19740375680353753 0.0743086817107321 27.15767656592524 -13.999999999999998 0.2639535051363346 6.998501095504266 0.030993258525455345 0.9995705020746061 0.008506285190396203 14.5955434267798 0.1625958613031142 46.810662854966594 0.05271771151533691 1.0000000000000041e-14 13.999999999999998 -6.96750783697881 AVTGVLASHPNSTDVHIINLSLTFHGQELLSDTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVTGVLASHPNSTDVHIINLSLTFHGQELLSDTK 34 0 Q9UG63;Q9UG63-2;C9JHK9;C9JZV3 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 0 228114000.0 98689000.0 107258000.0 22167000.0 False True 127754855.95102271 101288998.0126405 18132833.45262729 1.0 0.7928387321063678 0.14193459276083298 26.92880288801769 -7.108550102158957 0.6317461372204363 1.00178570835307 4.4541558403612405e-18 0.9983896606903943 0.014670551378595032 0.0779115662965532 0.050250434427190085 0.014530906634366314 0.0489021429844577 7.788429585543798e-08 7.108550102158957 -1.00178570835307 down AVTIFIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVTIFIR 7 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 99877000.0 29618000.0 39728000.0 30531000.0 False True 38829484.82112003 33800737.25853113 27371944.994031876 1.0 0.8704915198912534 0.7049268132227137 25.210649230305574 -6.96777741008806 0.30666687600886544 1.026531690099573 0.5436491069387809 0.9999594839376635 0.0007686587557870364 0.07703072430315401 0.011598315130167361 0.002659985789923293 0.014747258845546219 1.0770170781401723e-07 6.96777741008806 -0.482882583160792 AVTIFIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVTIFIR 7 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 116922000.0 48033000.0 25659000.0 43230000.0 False True 46508218.70693495 35904772.5099173 31906766.127799086 1.0 0.7720091955395284 0.686045757393013 25.47098234903462 -13.999999999999998 0.1353100529169599 2.0854233330872627 0.5734013682314741 0.9996222743273916 0.002574586889413369 11.93216193056488 0.11488340537181428 3.429841872586463 0.10041920296577682 1.0000000000000041e-14 13.999999999999998 -1.5120219648557884 AVTIFIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVTIFIR 7 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 543490000.0 132000000.0 213500000.0 197990000.0 False True 200253650.49263212 175399256.91688627 158857189.71790022 1.0 0.8758854407167957 0.7932798694411066 27.577253301356425 AVTIFIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVTIFIR 7 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 115806000.0 29618000.0 36338000.0 49850000.0 False True 40568574.99635449 34732467.00630324 38076456.692976855 1.0 0.856142149666936 0.938570228222175 25.273859291828465 -10.115993036677736 4.5335193723522575 1.0000100848589193 0.8973561889433453 0.6740058745837454 0.03365112216709782 46922360.80856733 0.6227700696105642 4939.72993549791 0.011519674183579872 7.656088823116103e-11 10.115993036677736 -0.10265389591557394 AVTIFIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVTIFIR 7 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 84956000.0 48033000.0 21147000.0 15776000.0 False True 39941567.7226955 21033076.91364913 19074688.660017505 1.0 0.526596178189014 0.47756484653903386 25.251387624468897 -13.999999999999961 0.3203889937740982 5.865238783123931 0.4678728280566046 0.9996945606486818 0.0041170718601722155 18.04357310845581 0.18052973502787673 58.85541592660273 0.016299503231663563 1.00000000000009e-14 13.999999999999961 -5.397365955067326 AVTIFIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVTIFIR 7 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 584390000.0 132000000.0 288960000.0 163430000.0 False True 170876602.1089992 272879121.98374534 133687416.93340895 1.0 1.5969367287025085 0.7823623321356313 27.348379623448874 -6.710240738465759 1.7940013201934562 1.366878996818868 0.7842311031639609 0.46644386461609877 0.2515347733511295 0.374570537187982 2.3500556914275665 0.1115625250214605 0.28337517043751514 1.948764059845169e-07 6.710240738465759 -0.582647893654907 AVTK(ub)YTSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVTKYTSAK 9 1 P57053;O60814 P57053 H2BFS;HIST1H2BK Histone H2B type F-S;Histone H2B type 1-K 1 454215400.0 231925000.0 162515400.0 59775000.0 True False 304055920.9648949 138268735.80006754 53590056.40228806 1.0 0.4547477166742348 0.1762506588663845 28.179761442897252 -9.008608940243535 0.2557161687953612 1.3087577259421352 3.3126515581217376e-21 0.9991073503427387 0.010221643443027924 0.4720127867718699 0.08663257492896678 0.24162674056844413 0.11105663947198192 9.803723627732934e-10 9.008608940243535 -1.3087577259421352 AVTK(ub)YTSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVTKYTSAK 9 1 P57053;O60814 P57053 H2BFS;HIST1H2BK Histone H2B type F-S;Histone H2B type 1-K 1 414491900.0 177860000.0 183875900.0 52756000.0 True False 172213931.65564194 257298505.77015105 38937620.95392471 1.0 1.4940632461991736 0.22610029618152014 27.35962661680172 -6.801016332136316 1.4516366845336057 1.2722421816104441 0.2081282072440212 0.8351657057256547 0.21186146643951084 0.2193005721221132 0.9122132632262843 0.11480746865785334 0.26685094895285655 1.5811885757634372e-07 6.801016332136316 -1.064113974366423 down AVTK(ub)YTSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVTKYTSAK 9 1 P57053;O60814 P57053 H2BFS;HIST1H2BK Histone H2B type F-S;Histone H2B type 1-K 1 392213300.0 177860000.0 182087300.0 32266000.0 True False 147898470.53397915 181106359.57340068 39012671.41887201 1.0 1.2245316595873257 0.2637800869611359 27.140031892235996 -6.845141065612365 1.258342068229178 1.1194886744199468 0.22883271189607304 0.9329273283758823 0.10627383145994916 0.1628834710504296 0.4987702030075282 0.0661617011107125 0.1526978807635809 1.4284299068663698e-07 6.845141065612365 -0.8906559625238738 down AVTK(ub)YTSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVTKYTSSK 9 1 P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P58876;P62807;Q16778;Q93079;U3KQK0 HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 8356100.0 2164800.0 4992600.0 1198700.0 True False 2838073.763953024 4247723.541002373 1074670.0227423275 1.0 1.4966924380027078 0.37866176573418886 21.436480656082136 -6.785930537601646 1.5124550458226886 1.279079632626005 0.3680535978551133 0.7878897226654985 0.2106477164101378 0.24147868994481975 1.0912706142311868 0.10965084521231826 0.25751174721976583 1.6370783398459708e-07 6.785930537601646 -0.9110260347708916 down AVTK(ub)YTSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVTKYTSSK 9 1 P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P58876;P62807;Q16778;Q93079;U3KQK0 HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 14104900.0 4972700.0 5034100.0 4098100.0 True False 4814844.360418362 7044242.382484695 3024684.669635279 1.0 1.463025978657516 0.6281998841957301 22.19905773310803 -6.7561527596266595 1.6269181373506703 1.2702335597678913 0.62571298117947 0.6750802943616576 0.19465744780910427 0.2894291463417606 1.508928124058796 0.09444437425351115 0.22783835985323345 1.7532636968220918e-07 6.7561527596266595 -0.6445205785884213 AVTK(ub)YTSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVTKYTSSK 9 1 P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P58876;P62807;Q16778;Q93079;U3KQK0 HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 7954200.0 2164800.0 3680500.0 2108900.0 True False 2965185.061520299 3517883.340214076 1610821.2541588575 1.0 1.1863958799287893 0.5432447623801812 21.499690717605027 -6.829174769844815 1.3316636758578249 1.099653366871517 0.5262358308010742 0.9042067779501917 0.08362436427099981 0.18182716381751435 0.6309093906451161 0.049310998260552186 0.11347854633734233 1.4819216066279312e-07 6.829174769844815 -0.5734175360704428 AVTK(ub)YTSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVTKYTSSK 9 1 P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P58876;P62807;Q16778;Q93079;U3KQK0 HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 16792600.0 4972700.0 10521000.0 1298900.0 True False 4135020.3779619774 10464321.284745015 1570493.9845649556 1.0 2.530657730374367 0.37980320313173477 21.979463008542307 -6.715587573550203 1.7750042000952155 1.9355974729421408 0.38391974797668826 0.4916594751717457 0.6444808559343622 0.363984510189493 2.2386570302610633 0.28855908085011417 0.7282292994214058 1.9249188546170308e-07 6.715587573550203 -1.5516777249654525 AVTLHDQGTAQWADLSSQFYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVTLHDQGTAQWADLSSQFYLR 22 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 8912900.0 4510800.0 2279000.0 2123100.0 False True 3750930.062322464 2266722.5746539203 2567030.3938947236 1.0 0.6043094744481675 0.6843717028158331 21.83881693291508 -10.098085004117644 7.257519690024424 1.0000001012437665 0.6443405886320058 0.9633859052098224 0.03268526786182698 5.3565164033953186e-08 6.62780918016402e-09 0.0316473834837757 0.010549124841265353 7.978385116795184e-11 10.098085004117644 -0.35565951261176065 AVVEGQLQVAK(ub)VSPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVVEGQLQVAKVSPR 15 1 Q9H3H3-1;Q9H3H3;Q9H3H3-3 Q9H3H3-1 C11orf68 UPF0696 protein C11orf68 1 7900100.0 1888500.0 2936400.0 3075200.0 True False 2475841.7882600175 2498300.5659975507 2757007.8034013608 1.0 1.009071168377571 1.113563805439661 21.239487695433134 -6.923992036461241 0.7945557944859737 0.9980089727585854 1.1320652099256359 0.9952199431183302 0.00356264937374164 0.09587945256739334 0.09385651096295475 0.0031363765012090553 0.009785608746239466 1.191263851705509e-07 6.923992036461241 0.1340562371670505 AVVEGQLQVAK(ub)VSPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVVEGQLQVAKVSPR 15 1 Q9H3H3-1;Q9H3H3;Q9H3H3-3 Q9H3H3-1 C11orf68 UPF0696 protein C11orf68 1 15786000.0 3521300.0 5882000.0 6382700.0 True False 3409518.2589621698 8230713.274224774 4710879.393104393 1.0 2.4140399461389417 1.381684752888916 21.70113648027343 -10.14882114164148 5.238901158484511 0.9999688134226832 1.8978623495145088 0.5021298574800719 0.4214572427978401 0.00015352413253393073 2.4943959681975447e-05 0.40808834224029233 0.13602474020758554 7.098700582355295e-11 10.14882114164148 0.8978935360918257 AVVEGQLQVAK(ub)VSPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVVEGQLQVAKVSPR 15 1 Q9H3H3-1;Q9H3H3;Q9H3H3-3 Q9H3H3-1 C11orf68 UPF0696 protein C11orf68 1 7609400.0 1888500.0 3488200.0 2232700.0 True False 2586729.484793554 3334079.790065139 1705382.24389989 1.0 1.2889170706349415 0.6592812483582897 21.302697756956025 -6.781932678741119 1.5282576349152892 1.1631813328832334 0.6539806527024706 0.7741941180664724 0.12228433195999887 0.24758429199877469 1.142254028173444 0.06301298505485223 0.14845096813288824 1.6522178935114116e-07 6.781932678741119 -0.5092006801807628 AVVGEK(ub)ILSGVIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVVGEKILSGVIR 13 1 Q15833;Q15833-2;Q15833-3;M0R0M7;M0R0D4 Q15833 STXBP2 Syntaxin-binding protein 2 1 33331400.0 5791400.0 10543000.0 16997000.0 True False 5607555.177052084 14752874.881018683 12544975.80092991 1.0 2.6308925039903635 2.237156016273897 22.418940480492658 -10.114820582132483 5.285209951694315 0.9999699260128558 2.434024260133242 0.9464852567624968 0.16074224800738568 5.696414141585223e-05 9.5405019483396e-06 0.1556412564437327 0.05187933746315075 7.676785709985226e-11 10.114820582132483 1.4340543341203862 AVVGEK(ub)ILSGVIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVVGEKILSGVIR 13 1 Q15833;Q15833-2;Q15833-3;M0R0M7;M0R0D4 Q15833 STXBP2 Syntaxin-binding protein 2 1 19816900.0 5382700.0 2489200.0 11945000.0 True False 8165949.428080986 2044982.8117916307 9584065.514320515 1.0 0.25042805246372996 1.1736621196015402 22.961189202270205 -6.690752422986964 1.8636236826961752 0.5303967588703571 1.1705094372021656 0.3739727948898053 0.3169682395629141 0.41507044724015646 2.79552138691909 0.13602962845126054 0.3539105081514719 2.0382036595145203e-07 6.690752422986964 0.6401126783318085 AVVGVVAGGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVVGVVAGGGR 11 0 P62917;E9PKZ0;E9PKU4;E9PP36 P62917 RPL8 60S ribosomal protein L8 0 110450000.0 40907000.0 30632000.0 38911000.0 False True 53629473.14395156 26061825.002600808 34884862.98066798 1.0 0.4859608620924913 0.6504793154881546 25.67652274460378 -10.390287543919593 5.192302672461682 1.0002947479665112 0.5682200887903036 0.9018072628737435 0.06716437734860672 0.00022932027149358543 2.692820283075018e-05 0.06507520441598386 0.021677209577452203 4.071106428985187e-11 10.390287543919593 -0.4320746591762076 AVVGVVAGGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVVGVVAGGGR 11 0 P62917;E9PKZ0;E9PKU4;E9PP36 P62917 RPL8 60S ribosomal protein L8 0 63448000.0 15927000.0 12015000.0 35506000.0 False True 15421406.102999032 16812652.15739729 26205913.442832153 1.0 1.0902152530778435 1.6993206240600744 23.87843097844888 -6.9333913677434245 0.718407486542096 0.9918014390570126 1.8358995853364866 0.9971638594310486 0.01654062270753056 0.09091456955110518 0.06933061543422991 0.015385745018521664 0.054122479730635706 1.1657586114182198e-07 6.9333913677434245 0.844098146279474 AVVGVVAGGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVVGVVAGGGR 11 0 P62917;E9PKZ0;E9PKU4;E9PP36 P62917 RPL8 60S ribosomal protein L8 0 94823000.0 18529000.0 59144000.0 17150000.0 False True 28109847.651348334 48589291.105818845 13760294.982887981 1.0 1.728550496199085 0.4895186609888278 24.744572298888887 -6.747337541467007 1.6597292581303469 1.429739679538258 0.48754367708263335 0.6375298582948987 0.3061072184462626 0.30465760625462496 1.6503621096056493 0.1457485862005646 0.3548286922234481 1.7892147037073407e-07 6.747337541467007 -0.9421960024556246 AVVGVVAGGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVVGVVAGGGR 11 0 P62917;E9PKZ0;E9PKU4;E9PP36 P62917 RPL8 60S ribosomal protein L8 0 88547000.0 40907000.0 18694000.0 28946000.0 False True 56031423.370108485 17868037.267208815 22109550.961582936 1.0 0.31889315302921634 0.3945919919888719 25.73973280612667 -10.474399827246295 6.141380867180287 1.0003806045403711 0.35674257251469227 0.9897202500074211 0.030903921595378813 0.0001611386473541728 1.379075832313113e-05 0.02993942515398912 0.009974197805950128 3.354286642595131e-11 10.474399827246295 -0.6436380320256789 AVVGVVAGGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVVGVVAGGGR 11 0 P62917;E9PKZ0;E9PKU4;E9PP36 P62917 RPL8 60S ribosomal protein L8 0 39961500.0 15927000.0 15629000.0 8405500.0 False True 13244006.1857342 15544803.474886397 10163051.187359113 1.0 1.173723664643898 0.7673698611154576 23.658836253883155 -6.790557989234662 1.4943235042995222 1.0970238601491233 0.7629947022903042 0.8030596925035786 0.07387743024118357 0.23452174484607807 1.0345853530876457 0.03891459035803176 0.09106302335737028 1.6197277050835667e-07 6.790557989234662 -0.33402915785881915 AVVGVVAGGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVVGVVAGGGR 11 0 P62917;E9PKZ0;E9PKU4;E9PP36 P62917 RPL8 60S ribosomal protein L8 0 64604000.0 18529000.0 29050000.0 17025000.0 False True 23986155.761194285 27433341.962997694 13926624.691251855 1.0 1.1437156598215874 0.580610950329226 24.515698620981336 -6.839015316024875 1.2869619996844979 1.0764656033671796 0.5624480626457844 0.9227496361490753 0.06639776704346186 0.16995015285929166 0.5472104738522393 0.040461973246617364 0.09319332296675141 1.4487207614047402e-07 6.839015316024875 -0.5140175407213952 AVVK(ub)TDIQIALPSGCYGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVVKTDIQIALPSGCYGR 18 1 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 16744500.0 6414200.0 3657700.0 6672600.0 True False 9730810.340832127 3004954.8572594593 5353757.685295525 1.0 0.30880828543643074 0.5501862124298376 23.214128520889737 -10.213212168702825 5.4376081583143865 1.0000300617191202 0.42949724893329455 0.8816334608084649 0.09854212605098456 3.591445584453929e-05 5.196453560324411e-06 0.09541801696080734 0.031804334424580125 6.120513092746212e-11 10.213212168702825 -0.5705328127858257 AVVMPLQLIQEQAASPNAEIHILKNK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVVMPLQLIQEQAASPNAEIHILKNK 26 1 H3BRB3;Q14807-2;Q14807;I3L306 H3BRB3 KIF22 Kinesin-like protein;Kinesin-like protein KIF22 1 13427400.0 5816900.0 3701500.0 3909000.0 True False 5632245.693510083 5179528.253067494 2885115.6325136814 1.0 0.9196204382624421 0.5122496051331956 22.425278838859967 -6.939503850542836 0.6641624888836416 1.0046139513150911 0.4039794262653184 0.9980981999351204 0.009311472566886633 0.0879936901859594 0.0556457379585181 0.009030307986116001 0.03513892946277608 1.1494660519758313e-07 6.939503850542836 -0.6006345250497727 AVVPAK(ub)YLDEDTIYHLQPSGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVVPAKYLDEDTIYHLQPSGR 21 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 85902700.0 3515700.0 56658000.0 25729000.0 True False 3404096.027896883 79281834.86756676 18989803.046545047 1.0 23.29012877951878 5.578515673741824 21.698840304649032 -9.74944880499978 8.401843384818182 1.0011523551639063 14.434322226616647 0.43410221963692974 7.230735802399109 1.7120964590217714e-07 0.0 7.001130343073511 2.3337099406830193 1.780537787780941e-10 9.74944880499978 13.43316987145274 AVVPAK(ub)YLDEDTIYHLQPSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVVPAKYLDEDTIYHLQPSGR 21 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 73641000.0 3620000.0 47047000.0 22974000.0 True False 4958411.826821632 44968307.976375945 17548014.364382148 1.0 9.069095014078503 3.539039308808385 22.241446670486418 -9.517284269503286 10.550670346520473 1.0000000000470357 6.304067149657224 0.5508817908520329 2.2576357878464584 0.0 0.0 2.1859464520327982 0.728648817344266 3.0388952513068893e-10 9.517284269503286 5.304067149610189 AVVPAK(ub)YLDEDTIYHLQPSGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVVPAKYLDEDTIYHLQPSGR 21 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 86684900.0 3515700.0 61411200.0 21758000.0 True False 2923460.321917856 61080365.67643123 26307497.202374544 1.0 20.89317416709837 8.998752952157815 21.479245580083308 -9.601256420119864 11.504344050416826 0.9999999437800834 14.945963559628092 0.6470102997025011 4.855877127056585 0.0 0.0 4.701682811079918 1.5672276036933057 2.5046300098243363e-10 9.601256420119864 13.945963615848008 AVVPAK(ub)YLDEDTIYHLQPSGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVVPAKYLDEDTIYHLQPSGR 21 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 355771000.0 145352000.0 98439000.0 111980000.0 True False 188161029.31626683 92960783.11516446 91600789.01182859 1.0 0.49404907835040124 0.4868212580717932 27.48739261652767 AVVVCPK(ub)DEDYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVVVCPKDEDYK 12 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 9441900.0 2650300.0 3590500.0 3201100.0 True False 3474568.965541711 3054811.395659385 2869880.879119433 1.0 0.879191469777926 0.8259674531088196 21.728402586053722 -13.99999999928675 0.11125344467926401 1.581687581960501 0.7300684981380801 0.9997366952596486 0.0011814886797222365 12.005436578005634 0.10141802094919015 1.5650525401096707 0.0851537331078176 1.0000000016423186e-14 13.99999999928675 -0.8516190838224209 AVVVCPK(ub)DEDYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVVVCPKDEDYK 12 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 6726500.0 2056300.0 2299900.0 2370300.0 True False 1709904.5595357076 2287509.9822055954 2865918.7709710677 1.0 1.3377998025964242 1.676069436149848 20.705484370852204 -6.971108393026379 0.2301886618624656 0.8627515125513103 2.1607851712244477 0.9999897817870514 0.0008822545121850621 0.07594474040106652 0.007731477219885077 0.008679631315043717 0.03358458048398878 1.0687880933455952e-07 6.971108393026379 1.2980336586731374 AVVVCPK(ub)DEDYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVVVCPKDEDYK 12 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 10264900.0 4006800.0 2624300.0 3633800.0 True False 5186881.585835889 2478255.3980549 2972485.6859366186 1.0 0.47779293917609617 0.5730776067943701 22.306436003325242 -10.126111660107906 5.380568921731816 1.0000086298629267 0.5254352729881852 0.9706519047219868 0.038899802665990094 4.39808545709814e-06 7.142894435209792e-07 0.037665319314733936 0.012554857324168157 7.479771656966069e-11 10.126111660107906 -0.47457335687474156 AVVVGFDPHFSYMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVVVGFDPHFSYMK 14 0 A6NDG6 A6NDG6 PGP Phosphoglycolate phosphatase 0 11000500.0 3677200.0 6024300.0 1299000.0 False True 4820844.810055454 5125497.922537483 1164591.9408878663 1.0 1.0631949636392724 0.24157424409487888 22.200854557372576 -6.888334935370326 1.0322062507093126 1.045925087694719 0.17317641236847173 0.9798100943332099 0.05304449732182001 0.12050352610829479 0.22983438052493 0.039239750648097226 0.09725477261694432 1.293198120148123e-07 6.888334935370326 -0.8727486753262473 down AVVVGFDPHFSYMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVVVGFDPHFSYMK 14 0 A6NDG6 A6NDG6 PGP Phosphoglycolate phosphatase 0 14125100.0 6370100.0 3172000.0 4583000.0 False True 6167884.662316454 4438596.141761473 3382574.8129470963 1.0 0.7196302111288967 0.5484173258967383 22.55634435684368 -9.836872891439551 0.0913753401354575 1.7826757073572543 1.669895778195166e-11 0.9999545574352146 0.0012548072957349516 1.38619333410863 0.040641607920620625 0.5266493342816665 0.27439484467466474 1.455885124180972e-10 9.836872891439551 -1.7826757073405555 AVVVGFDPHFSYMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVVVGFDPHFSYMK 14 0 A6NDG6 A6NDG6 PGP Phosphoglycolate phosphatase 0 18450900.0 3677200.0 5339000.0 9434700.0 False True 5036760.21259351 5103105.326287995 7206418.173745821 1.0 1.0131721803091998 1.430764592629896 22.264064618895468 -6.913622845606118 0.8707110882224157 0.9885041673971747 1.4891299223884498 0.992218067601323 0.01764587072143134 0.10207094308331864 0.1261373064792098 0.01471080367288916 0.04170328433737892 1.2200486659622885e-07 6.913622845606118 0.500625754991275 AVVVGFDPHFSYMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVVVGFDPHFSYMK 14 0 A6NDG6 A6NDG6 PGP Phosphoglycolate phosphatase 0 11821500.0 6370100.0 3070400.0 2381000.0 False True 5297020.393278423 3053859.1457733163 2878856.0914998595 1.0 0.576523954797015 0.5434859369529599 22.336749632277957 -13.999999999999998 0.3616889391017529 6.599510362018401 0.539603538649977 0.9997763329785335 0.003108551399348789 21.880070879797977 0.1944995841489913 94.64364036612567 0.009481285895202769 1.0000000000000041e-14 13.999999999999998 -6.059906823368424 AVYTLTSLYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVYTLTSLYR 10 0 Q9NR28-2;Q9NR28;H7BZK7;A0A2U3TZH2;H7BZQ7 Q9NR28-2 DIABLO Diablo homolog, mitochondrial 0 15997000.0 4924200.0 4248300.0 6824500.0 False True 6455673.88602063 3614470.1997436965 6118366.205226513 1.0 0.5598904566060272 0.9477501982365409 22.622136270786207 -10.244612464254653 7.987285839680345 1.000000227906138 0.7538203274212841 0.34944442219155514 0.15834307646041282 6.42470744172304e-07 6.092366309656446e-08 0.1533151661704541 0.051105008176535564 5.693607642170378e-11 10.244612464254653 -0.24617990048485383 AVYTLTSLYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVYTLTSLYR 10 0 Q9NR28-2;Q9NR28;H7BZK7;A0A2U3TZH2;H7BZQ7 Q9NR28-2 DIABLO Diablo homolog, mitochondrial 0 11780400.0 3799800.0 1536300.0 6444300.0 False True 3679177.428905364 2149752.601698662 4756344.505144005 1.0 0.5843025087100137 1.2927738868410925 21.810951821506098 -6.747710851748022 1.6586000503595293 0.7548914820880355 1.293915744712694 0.6389514932653362 0.17466167052206497 0.3040519411227098 1.645005345493679 0.08321845979432087 0.20249747759701972 1.787677393693671e-07 6.747710851748022 0.5390242626246586 AVYTLTSLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVYTLTSLYR 10 0 Q9NR28-2;Q9NR28;H7BZK7;A0A2U3TZH2;H7BZQ7 Q9NR28-2 DIABLO Diablo homolog, mitochondrial 0 12895800.0 4924200.0 3499100.0 4472500.0 False True 6744809.811501402 3344498.19202366 3416187.6140288673 1.0 0.49586249063992077 0.5064913184362155 22.6853463323091 -10.013239423198131 5.21163587786023 1.0000035917798478 0.5011769045361905 0.9996595982302138 0.0043392007840275665 1.8109155452678029e-07 3.429080932763124e-08 0.004201443352270973 0.0014004710300886164 9.699750800392974e-11 10.013239423198131 -0.4988266872436573 AVYTLTSLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVYTLTSLYR 10 0 Q9NR28-2;Q9NR28;H7BZK7;A0A2U3TZH2;H7BZQ7 Q9NR28-2 DIABLO Diablo homolog, mitochondrial 0 9809600.0 3799800.0 3757000.0 2252800.0 False True 3159702.0596818496 3736760.2952938876 2723850.064229686 1.0 1.1826305850084302 0.8620591475969573 21.591357096940374 -6.752147208949211 1.6416611345524597 1.107108450951467 0.8613064766318068 0.6582710105755138 0.07675245304773551 0.2963062348163032 1.5717611145528811 0.036921066262139 0.08944157085117585 1.7695090618576678e-07 6.752147208949211 -0.24580197431966022 AVYTQDCPLAAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVYTQDCPLAAAK 13 0 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 7651900.0 3984200.0 0.0 3667700.0 False True 3857723.7518408187 0.0 2707019.3413585145 1.0 0.0 0.7017141494558251 21.879318406304094 -10.533597538195263 8.505423706183551 1.0000700470374586 0.3508570771150652 0.5329361500449158 0.28647360190964427 0.00038055586108240127 2.0867890869037166e-05 0.27740628291981384 0.09245895744367542 2.9268634533008296e-11 10.533597538195263 -0.6492129699223934 AVYTQDCPLAAAK(ub)AIQGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVYTQDCPLAAAKAIQGLR 19 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 18814700.0 3404900.0 6686200.0 8723600.0 True False 4463856.873098506 5688645.022603467 7820965.554680038 1.0 1.2743789024433476 1.7520645883189476 22.0898593393718 -6.962663885074037 0.39610563473485544 0.9725861127991936 2.071190281390317 0.9998565981041997 0.0037211971862236427 0.07876289462449104 0.017713152574378346 0.006151405376606569 0.04008193731721493 1.0897731787086103e-07 6.962663885074037 1.0986041685911232 AVYTQDCPLAAAK(ub)AIQGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVYTQDCPLAAAKAIQGLR 19 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 24011500.0 5809300.0 6169200.0 12033000.0 True False 5624886.951350055 8632593.731953003 8881196.31773782 1.0 1.5347141741010555 1.5789110776006268 22.423392670744413 -11.573987918196172 0.410668323423421 7.120355649215752e-09 1.5813217365426293 0.9997001312035266 0.004556084502011234 4.200154326257467 0.20591390634815068 3.718624108821865 0.01097548072303205 2.6669328559117567e-12 11.573987918196172 1.5813217294222737 AVYTQDCPLAAAK(ub)AIQGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVYTQDCPLAAAKAIQGLR 19 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 103229300.0 6293300.0 37449000.0 59487000.0 True False 9547396.2018582 30765933.359627545 47729368.375921644 1.0 3.222442298313712 4.999202648218592 23.18667589945047 -7.673738776432039 0.2323980726981114 4.034367230782388e-14 7.005598632066605 0.9998324451612612 0.021177434787428975 0.13603287886356444 0.030426323226928526 0.256853580054431 0.49408929959319214 2.119635690492215e-08 7.673738776432039 7.005598632066565 AVYTQDCPLAAAK(ub)AIQGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVYTQDCPLAAAKAIQGLR 19 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 17618600.0 3404900.0 6163200.0 8050500.0 True False 4663783.543962703 5890889.445023076 6149137.705251963 1.0 1.2631138193900249 1.318486942476578 22.15306940089469 -12.977526877668883 0.2335113633439749 4.233096784740119e-22 1.345581256305904 0.9994534789924795 0.003248012157414746 8.336980243879092 0.14752320816247888 3.893152923950713 0.028124575203073085 1.0531085102073578e-13 12.977526877668883 1.345581256305904 AVYTQDCPLAAAK(ub)AIQGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVYTQDCPLAAAKAIQGLR 19 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 20613500.0 5809300.0 5770500.0 9033700.0 True False 4830690.345626026 5739413.171145423 10922604.902890475 1.0 1.1881144847841891 2.261085708542756 22.20379794617869 -6.936916323537089 0.6876593700971559 0.9870752283961641 2.5259371602972074 0.9977313766545055 0.02645740262158925 0.08920209715919476 0.061231156144725775 0.02518806490193899 0.09367184115650029 1.1563350143139627e-07 6.936916323537089 1.5388619319010433 up AVYTQDCPLAAAK(ub)AIQGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVYTQDCPLAAAKAIQGLR 19 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 72220300.0 6293300.0 18461000.0 47466000.0 True False 8146800.90948913 17433629.12147675 38827675.04228835 1.0 2.1399355790284043 4.766002689112376 22.95780222154292 -6.957189182012531 0.47338669965459573 0.9328726862109481 6.081337772744278 0.9996513292779486 0.029444321760562223 0.08072089374883813 0.024960316890443156 0.03654476090234569 0.2166958166196731 1.1035977795102919e-07 6.957189182012531 5.14846508653333 AVYTSGK(ub)ASSAAGLTAAVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AVYTSGKASSAAGLTAAVVR 20 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 60933000.0 15375000.0 26901000.0 18657000.0 True False 20156773.891711794 22887475.6592767 16726552.61058114 1.0 1.1354731556862747 0.8298229022382834 24.264761416994286 -6.786215980788153 1.5114216991862472 1.0760894046133598 0.8269023962766272 0.7888398420127346 0.05746272947864711 0.24103373037939038 1.0877904234094002 0.029932409657058383 0.07027700938300693 1.6360027117982124e-07 6.786215980788153 -0.24918700833673257 AVYTSGK(ub)ASSAAGLTAAVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AVYTSGKASSAAGLTAAVVR 20 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 79653000.0 22279000.0 34875000.0 22499000.0 True False 21571765.339908022 48800769.37072245 16605836.944467979 1.0 2.262252004032347 0.7697949927976911 24.36264090945893 -6.682586801039585 1.8931009255357254 1.7968082361407969 0.7754149467131841 0.33579930711675476 0.53467703816637 0.4328155105309694 3.001267884052358 0.22646538304526928 0.5952268344170161 2.07688858305424e-07 6.682586801039585 -1.0213932894276128 AVYTSGK(ub)ASSAAGLTAAVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AVYTSGKASSAAGLTAAVVR 20 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 152264000.0 49479000.0 56875000.0 45910000.0 True False 75063260.39943144 46725211.88359673 36835868.37693221 1.0 0.6224777825391482 0.49073099384331065 26.161603619769956 -13.999999999999993 0.14678685771446917 2.8170517486887503 0.3402886877690648 0.9995773158194386 0.0044372635572327256 11.947077458244047 0.12048647959965592 6.198369499371094 0.135199938704067 1.0000000000000164e-14 13.999999999999993 -2.4767630609196853 AVYTSGK(ub)ASSAAGLTAAVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AVYTSGKASSAAGLTAAVVR 20 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 66284000.0 15375000.0 21957000.0 28952000.0 True False 21059552.9937521 20986867.137910753 22114133.885156818 1.0 0.9965485565689399 1.05007612895286 24.327971478517178 -6.891511751780253 1.0134143167624996 0.9972272631920244 1.0548184005131562 0.9818477381805184 0.003295531880947297 0.11792441185994021 0.21475992045927592 0.0024727809542390306 0.006199092734276867 1.2837730317794635e-07 6.891511751780253 0.05759113732113186 AVYTSGK(ub)ASSAAGLTAAVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AVYTSGKASSAAGLTAAVVR 20 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 72908000.0 22279000.0 33636000.0 16993000.0 True False 18525975.627046645 33454796.191776715 20546157.73324529 1.0 1.805831815029219 1.1090459227015996 24.143046184893205 -10.232892481552277 5.002187576244451 0.9999334623469959 1.4574388688656872 0.3649397107293936 0.2844616493633526 0.00021113768782825572 3.237826736654986e-05 0.2754687093545688 0.0918096025513989 5.84934878767569e-11 10.232892481552277 0.4575054065186913 AVYTSGK(ub)ASSAAGLTAAVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AVYTSGKASSAAGLTAAVVR 20 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 167442000.0 49479000.0 60106000.0 57857000.0 True False 64051540.87690285 56761048.262579605 47327619.66295195 1.0 0.8861777169680517 0.7388990025065645 25.932729941862405 -6.967596491259 0.3102740053791696 1.02261621624863 0.5977770895331145 0.9999570984411136 0.0007000674229063583 0.07709058707405902 0.011807734277854757 0.0023273656345127584 0.013072074745004887 1.0774658364559515e-07 6.967596491259 -0.4248391267155156 AWDIAIATMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AWDIAIATMK 10 0 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 35359400.0 9873400.0 11980000.0 13506000.0 False True 12944123.014141595 10192630.697674258 12108528.678700175 1.0 0.7874330834571565 0.935446044932629 23.62579388777259 -10.010494119671405 5.019564137245135 1.0000014953780516 0.8614395642570369 0.5388454473630839 0.060426038493434184 1.011237939503708e-06 1.9939539475055446e-07 0.05850789137882041 0.019502420062874365 9.761259990447561e-11 10.010494119671405 -0.13856193112101467 AWDIAIATMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AWDIAIATMK 10 0 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 26975500.0 9542100.0 4771400.0 12662000.0 False True 9239191.258581478 6676644.9025222855 9345442.348142296 1.0 0.7226438673753974 1.0115000422209175 23.13933514192891 -11.052553334317599 11.344117749938409 1.5245511347315535 0.8670719547981575 0.22018994818659932 0.11792503957061429 0.04242342752389457 0.0001965331736705281 0.0030962218350048826 0.0380601428631533 8.860264069060514e-12 11.052553334317599 -0.657479179933396 AWDIAIATMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AWDIAIATMK 10 0 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 38588800.0 7037800.0 21524000.0 10027000.0 False True 10676857.13209883 17682874.032220438 8045159.055009769 1.0 1.6561871919273667 0.7535137873881311 23.347983698201492 -6.711752202708678 1.7889753432617883 1.402681009953827 0.7555218572657348 0.47344507848121653 0.2764382709928226 0.37154748028308154 2.319042525684903 0.12291923677885433 0.3116090160565929 1.9419936132817613e-07 6.711752202708678 -0.6471591526880921 AWDIAIATMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AWDIAIATMK 10 0 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 32401400.0 9873400.0 10039000.0 12489000.0 False True 13523862.798602393 9595443.785466406 9539355.419028861 1.0 0.7095194567086288 0.7053720938380634 23.689003949295483 AWDIAIATMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AWDIAIATMK 10 0 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 18406900.0 9542100.0 3736800.0 5128000.0 False True 7934678.936704616 3716669.116703277 6200241.090806907 1.0 0.46840825524906016 0.7814104565876682 22.919740417363187 -10.263945623198763 5.9023409403003 1.0000169704105584 0.6249093559183678 0.6569196535057175 0.12778261360791923 2.853721269636891e-05 3.558709074348159e-06 0.12373057625050654 0.04124166120319305 5.445708327696935e-11 10.263945623198763 -0.37510761449219054 AWDIAIATMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AWDIAIATMK 10 0 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 30247200.0 7037800.0 13733000.0 9476400.0 False True 9110570.835778136 12968746.477722785 7751792.436075116 1.0 1.4234834141010355 0.8508569414369779 23.11911002029394 -6.708603174089288 1.80024220040671 1.2607181096426558 0.8522596233987373 0.45845832620646376 0.1784927862323013 0.377879854368818 2.3864029408262186 0.07892936376304768 0.20085368284481903 1.9561260015100202e-07 6.708603174089288 -0.40845848624391856 AWEDYYK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 AWEDYYKK 8 1 Q96I24 Q96I24 FUBP3 Far upstream element-binding protein 3 1 18937900.0 1770900.0 1369200.0 15797800.0 True False 2686584.7701318357 1124855.562391572 12675357.905578272 1.0 0.41869349327710703 4.718018968355973 21.357341929617245 -6.872785828823994 1.1193050135251132 0.6650168971363405 4.983449724466082 0.9673828064159246 0.3439660490084794 0.1342091894954123 0.3125737885661406 0.2380728246004085 0.5665155400012241 1.3403375083715288e-07 6.872785828823994 4.318432827329741 up AWEEYYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AWEEYYK 7 0 A0A087WTP3;Q92945;M0R3J3;M0QYG1;M0R0C6;M0R251;M0R263;Q96AE4;E9PEB5;Q96AE4-2 A0A087WTP3;Q96AE4;Q96AE4-2 KHSRP;FUBP1 Far upstream element-binding protein 2;Far upstream element-binding protein 1 0 6211860.0 327660.0 3398400.0 2485800.0 False True 429565.4330639538 2891371.966859446 2228593.2614773326 1.0 6.730923264090893 5.188018145644272 18.712518379413655 -9.996898831844007 7.203705341484954 0.9999997161176979 5.959470704867584 0.9323238217772444 0.6298883769537854 2.9817960932508536e-06 4.1884326746662887e-07 0.6098868348151262 0.20329559949263462 1.007166259182718e-10 9.996898831844007 4.959470988749887 AWEEYYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AWEEYYK 7 0 A0A087WTP3;Q92945;M0R3J3;M0QYG1;M0R0C6;M0R251;M0R263;Q96AE4;E9PEB5;Q96AE4-2 A0A087WTP3;Q96AE4;Q96AE4-2 KHSRP;FUBP1 Far upstream element-binding protein 2;Far upstream element-binding protein 1 0 6002560.0 327660.0 2704100.0 2970800.0 False True 448804.7566785572 2584623.920737101 2269158.225546556 1.0 5.758904918622019 5.056003065430458 18.775728440936547 -10.437010521984849 4.989045744971904 0.9931544667938128 5.407453992026571 0.9812816001269367 0.2869584799305872 0.02174745216132427 0.002454087356678069 0.27654593772140634 0.09261545115183421 3.6558593417555794e-11 10.437010521984849 4.414299525232758 AWLMASRQQLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AWLMASRQQLAK 12 1 G3V2W1;Q9UK55 G3V2W1 SERPINA10 Protein Z-dependent protease inhibitor 0 4824200.0 1545900.0 1281900.0 1996400.0 False True 2026689.870516897 1090645.516807063 1789831.6788210438 1.0 0.5381412976268044 0.8831305197990437 20.950693909979783 -10.30726895114628 5.896847039265468 1.0000237966378758 0.7106359087129238 0.48401224492748085 0.14084126018027746 4.406594274521709e-05 5.176749059167519e-06 0.1363801649728375 0.045456321261422905 4.9286848440068256e-11 10.30726895114628 -0.28938788792495196 AWLMASRQQLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AWLMASRQQLAK 12 1 G3V2W1;Q9UK55 G3V2W1 SERPINA10 Protein Z-dependent protease inhibitor 0 4548300.0 1545900.0 1417900.0 1584500.0 False True 2117461.0063766767 1355252.4896317192 1210273.733801844 1.0 0.640036574723413 0.5715683689839565 21.013903971502675 -13.999999999999998 0.23336642146843406 3.308318644453019 0.5393272029233731 0.9995145710051093 0.004140268717394696 13.398463634299716 0.15293437040903163 14.35794883297458 0.03481165955732953 1.0000000000000041e-14 13.999999999999998 -2.7689914415296455 AWLYLALMQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AWLYLALMQK 10 0 Q96T51;Q96T51-3;Q96T51-2;J3KPP6;H0Y9Y8;H0YAC8 Q96T51 RUFY1 RUN and FYVE domain-containing protein 1 0 15210400.0 3928600.0 5976100.0 5305700.0 False True 5959973.419131472 4909618.263517588 4257026.069429076 1.0 0.8237651275017015 0.7142693045851602 22.506874465754443 AWLYLALMQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AWLYLALMQK 10 0 Q96T51;Q96T51-3;Q96T51-2;J3KPP6;H0Y9Y8;H0YAC8 Q96T51 RUFY1 RUN and FYVE domain-containing protein 1 0 13534200.0 3928600.0 4606900.0 4998700.0 False True 5085650.144283439 4350521.965209436 4088987.8909932766 1.0 0.8554505012696696 0.8040246133701376 22.278000787846892 -13.999999999991468 0.14394951751537788 1.6932747157189898 0.7433119699642398 0.9995876638387813 0.0016846391920700028 11.940055296571318 0.11914383032388501 2.3205378592500625 0.05443293740969683 1.0000000000196453e-14 13.999999999991468 -0.94996274575475 AWNDIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AWNDIKK 7 1 P36578;H3BM89;H3BTP7 P36578 RPL4 60S ribosomal protein L4 1 15024400.0 2724400.0 0.0 12300000.0 True False 2265459.3113840786 0.0 14871873.131225636 1.0 0.0 6.564617186675354 21.11137214898962 -6.868055205947043 1.1442653547369732 0.4405168960030311 6.935237843409299 0.9627069851070859 0.5576919193663449 0.1387369204947394 0.3407148915992608 0.37865954667646723 0.8936325314439952 1.355017156512716e-07 6.868055205947043 6.494720947406267 up AWNPFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AWNPFR 6 0 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 7423300.0 1925100.0 2276500.0 3221700.0 False True 2523824.742694921 1936855.0737274978 2888349.388728585 1.0 0.7674285147309154 1.1444334227599446 21.267180300712955 -6.739832481870534 1.6873086943175122 0.8615897324706598 1.1446448212512506 0.6041220583831579 0.09771753747539648 0.31815405512353784 1.7784577138349817 0.04581604472324225 0.11244917954083054 1.8204028976527973e-07 6.739832481870534 0.2830550887805907 AWNPFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AWNPFR 6 0 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 5049620.0 2127400.0 777620.0 2144600.0 False True 2059866.8514798875 1088127.7212347288 1582864.923379086 1.0 0.5282514840476102 0.7684306984414526 20.97411965483077 -10.499372583538891 7.4134206472504935 1.0000683528795185 0.6483410912445421 0.7408199692247469 0.0980527536812398 0.00011079597947698662 7.482102025350373e-06 0.09495749374066424 0.031646390171434974 3.166849440379903e-11 10.499372583538891 -0.35172726163497636 AWNPFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AWNPFR 6 0 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 6150300.0 1925100.0 2306500.0 1918700.0 False True 2636861.493871363 2204591.2034244714 1465542.576866897 1.0 0.8360663647098715 0.5557905033211397 21.330390362235846 -6.962991953913691 0.3909877131671628 1.0170252188378976 0.3647451079832181 0.9998655798966711 0.002126434249678893 0.07864915555416424 0.017305018467766824 0.0036167442233067016 0.023566474847558954 1.0889502679086206e-07 6.962991953913691 -0.6522801108546796 AWSDDTSQLGPDK(ub)HAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AWSDDTSQLGPDKHAR 16 1 Q92759;Q92759-2 Q92759 GTF2H4 General transcription factor IIH subunit 4 1 24172800.0 4297800.0 5303000.0 14572000.0 True False 6520076.811266921 4356638.217471891 11691837.812865498 1.0 0.6681881737870737 1.7932055328951941 22.636457529881927 -6.827717770550188 1.338112627153296 0.8224044593647084 1.8220844423929197 0.9012270310152379 0.14833658977384243 0.18364353437809938 0.6438949452124073 0.08705980140256846 0.20037354646080224 1.486901602281146e-07 6.827717770550188 0.9996799830282113 AWSDDTSQLGPDK(ub)HAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AWSDDTSQLGPDKHAR 16 1 Q92759;Q92759-2 Q92759 GTF2H4 General transcription factor IIH subunit 4 1 23866000.0 4297800.0 5292200.0 14276000.0 True False 5563586.822303455 4997684.417782314 11677914.484129876 1.0 0.8982846098037804 2.098990248038395 22.407583851974376 -6.8863149864295155 1.0439790085023064 0.9296704681612146 2.195087519017767 0.9784312713962462 0.07983937146945666 0.12218212974731102 0.2397433216498477 0.0585361732906748 0.14411832004829855 1.2992269289520147e-07 6.8863149864295155 1.2654170508565525 up AWSHFLLTYKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AWSHFLLTYKPK 12 1 Q9NU22 Q9NU22 MDN1 Midasin 0 7289800.0 1212100.0 2225800.0 3851900.0 False True 1589074.8379930963 1893719.3161004465 3453342.3380338494 1.0 1.191711850709371 2.1731779117434193 20.599755639799824 -6.939280650092893 0.6662309319922434 0.9888348227073775 2.4323320975300584 0.9980680432953604 0.02258577288855984 0.08809649850503459 0.05611752794224524 0.021867426841045236 0.08474415422987863 1.1500569581243068e-07 6.939280650092893 1.4434972748226809 up AWSHFLLTYKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AWSHFLLTYKPK 12 1 Q9NU22 Q9NU22 MDN1 Midasin 0 4995700.0 1212100.0 1396300.0 2387300.0 False True 1660246.125770856 1334606.8490533656 1823468.9079868335 1.0 0.8038608422794571 1.0983124006027678 20.662965701322715 -6.727131312962417 1.7334675145769487 0.8815901283527016 1.098054536250239 0.546005375040985 0.08247259034550114 0.3416475473253854 2.009844076282976 0.03772161238663299 0.093917092987101 1.874427671795541e-07 6.727131312962417 0.2164644078975374 AWTVLTEYYK(ub)SLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AWTVLTEYYKSLEK 14 1 O43252 O43252 PAPSS1 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 1 11896500.0 2775000.0 6008900.0 3112600.0 True False 3638051.8731382308 5112395.542508748 2790538.010167492 1.0 1.4052563626858705 0.7670418420285848 21.79473468311779 -6.7351669185968 1.7047581474728297 1.2424704275316394 0.7670745343217502 0.5829098681820506 0.1703014793987182 0.326624530218706 1.8619208135182237 0.07909836741321928 0.1951120651659053 1.840064647235262e-07 6.7351669185968 -0.4753958932098892 AWTVLTEYYK(ub)SLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AWTVLTEYYKSLEK 14 1 O43252 O43252 PAPSS1 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 1 23499900.0 9368700.0 8345100.0 5786100.0 True False 9071295.74666711 11677341.949121583 4270546.830720748 1.0 1.28728489018914 0.4707758351159251 23.112877209799475 -6.8116209742114 1.4076891593537373 1.1562690070813404 0.4559522652202774 0.8640274540806797 0.12470242380480567 0.2045948438265821 0.7987382104122351 0.06964987143384285 0.16100085545288262 1.5430465425697544e-07 6.8116209742114 -0.700316741861063 down AWTVLTEYYK(ub)SLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AWTVLTEYYKSLEK 14 1 O43252 O43252 PAPSS1 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 1 14852400.0 2775000.0 6393400.0 5684000.0 True False 3800992.491555262 6110918.447853462 4341556.265654582 1.0 1.6077165270466087 1.1422164803798747 21.857944744640683 -10.116807378081532 4.986646368523733 0.9999852149365624 1.37496650371447 0.463845976933174 0.19003959826680025 3.123896358404116e-05 5.5327143859601936e-06 0.1840122996703417 0.06133501659999656 7.641746415496045e-11 10.116807378081532 0.3749812887779076 AWTVLTEYYK(ub)SLEK(ub)A ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AWTVLTEYYKSLEKA 15 2 O43252 O43252 PAPSS1 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 2 6857400.0 1450900.0 4252600.0 1153900.0 True False 1987336.9390982075 4064706.0705323727 881372.5853164701 1.0 2.045302933068215 0.4434942902618264 20.92240506151733 -6.7306098499215565 1.7210323646108623 1.6286255500710942 0.4443434341990411 0.5621028725893605 0.4393986424517842 0.3350846984747484 1.9446922861215847 0.20230258390651773 0.5016489540008867 1.859474170584641e-07 6.7306098499215565 -1.1842821158720531 AWVLEK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 AWVLEKK 7 1 O43709;O43709-3;H7C0G4 O43709 WBSCR22 Probable 18S rRNA (guanine-N(7))-methyltransferase 1 18383700.0 6015100.0 7298500.0 5070100.0 True False 7885854.350311259 6209592.249330178 4545494.687833385 1.0 0.7874343062251818 0.5764111896961388 22.910835633811985 -6.971215494086867 0.22729699137448978 1.0887772638749136 0.26905819770586636 0.9999903705934318 0.000536592302761941 0.07591028878187468 0.007604085379821231 0.005531822806182218 0.021070354735437898 1.0685245527534723e-07 6.971215494086867 -0.8197190661690472 AWVLEK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 AWVLEKK 7 1 O43709;O43709-3;H7C0G4 O43709 WBSCR22 Probable 18S rRNA (guanine-N(7))-methyltransferase 1 28644500.0 9745100.0 9190300.0 9709100.0 True False 9435747.134698046 12860034.716781368 7165995.443243435 1.0 1.3629058232698075 0.7594518315239648 23.16970532613753 -6.743855307931463 1.67244787260771 1.2149600390722013 0.7587840158102963 0.6221385936508206 0.15247211466045435 0.31090522444649826 1.7088939857946028 0.0720782639083102 0.17613976121319497 1.8036185447858763e-07 6.743855307931463 -0.456176023261905 AWVLEK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AWVLEKK 7 1 O43709;O43709-3;H7C0G4 O43709 WBSCR22 Probable 18S rRNA (guanine-N(7))-methyltransferase 1 16311900.0 6015100.0 6155100.0 4141700.0 True False 8239045.021965414 5883147.329806184 3163515.7609890164 1.0 0.7140569464205655 0.38396631558087585 22.974045695334876 -6.969243927354741 0.2756462970498873 1.0766398513975273 0.011384227653219774 0.9999758698419949 0.001236447281451917 0.07654879655003068 0.009904976888100173 0.006254214867390876 0.030468318677311382 1.073386361070621e-07 6.969243927354741 -1.0652556237443076 down AWVLEK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AWVLEKK 7 1 O43709;O43709-3;H7C0G4 O43709 WBSCR22 Probable 18S rRNA (guanine-N(7))-methyltransferase 1 32549400.0 9745100.0 17427000.0 5377300.0 True False 8103482.43112942 17333117.29201134 6501668.568173944 1.0 2.138971416218094 0.8023301862416423 22.950110601571808 -6.680988560684132 1.8981818279278602 1.7199885385456697 0.807352902350136 0.3287497815065873 0.48261711294369125 0.4363247973711505 3.0403343756846257 0.2039419446588452 0.5372409725267222 2.084545789306491e-07 6.680988560684132 -0.9126356361955337 AWVLEK(ub)K(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 AWVLEKKER 9 2 O43709;O43709-3;H7C0G4 O43709 WBSCR22 Probable 18S rRNA (guanine-N(7))-methyltransferase 2 28535300.0 10677000.0 11905000.0 5953300.0 True False 13997650.396215094 10128820.405326547 5337309.62408601 1.0 0.7236086142046624 0.3813003949240793 23.738681345223902 -6.968244925328306 0.29713051552311914 1.0614290041014967 0.03279759596844618 0.9999652739651911 0.001491243683708757 0.0768763972901036 0.01105763681224966 0.005761413907176038 0.030794774547838955 1.0758582999443325e-07 6.968244925328306 -1.0286314081330505 down AWVLEK(ub)K(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AWVLEKKER 9 2 O43709;O43709-3;H7C0G4 O43709 WBSCR22 Probable 18S rRNA (guanine-N(7))-methyltransferase 2 38722300.0 14245000.0 16317000.0 8160300.0 True False 13792800.272318786 22832463.192030903 6022872.626247481 1.0 1.655389967318972 0.43666786347475633 23.717412052815206 -6.760629421464992 1.6100075251240935 1.380389811237273 0.4320624120597654 0.6935616362120263 0.27568506117935243 0.28186434314708325 1.440121712301353 0.13509149750412758 0.32445678957569385 1.7352840643304235e-07 6.760629421464992 -0.9483273991775076 AWVLEK(ub)K(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 AWVLEKKER 9 2 O43709;O43709-3;H7C0G4 O43709 WBSCR22 Probable 18S rRNA (guanine-N(7))-methyltransferase 2 51527200.0 30803000.0 14123000.0 6601200.0 True False 46730403.00094356 11602640.30649734 5296469.926591262 1.0 0.24828889890513173 0.1133409854497578 25.477858143206582 -13.999999999999998 0.24156454261576968 6.01359589190179 0.0545536271401123 0.9995275833920253 0.008478391703166142 13.67917124469205 0.15555079638799146 33.11330851553539 0.06533992071067417 1.0000000000000041e-14 13.999999999999998 -5.959042264761678 AWVLEK(ub)K(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AWVLEKKER 9 2 O43709;O43709-3;H7C0G4 O43709 WBSCR22 Probable 18S rRNA (guanine-N(7))-methyltransferase 2 29984400.0 10677000.0 12198000.0 7109400.0 True False 14624575.435075866 11659052.02660815 5430306.142689072 1.0 0.7972232820273779 0.3713137633838532 23.801891406746794 -6.9590759759028415 0.4482701224161094 1.0139801482362065 0.13772130639484564 0.9997343674724363 0.004270022547740005 0.08003292133509737 0.022363842773168018 0.005678269964611758 0.03523898482339862 1.098813595088703e-07 6.9590759759028415 -0.8762588418413608 down AWVLEK(ub)K(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AWVLEKKER 9 2 O43709;O43709-3;H7C0G4 O43709 WBSCR22 Probable 18S rRNA (guanine-N(7))-methyltransferase 2 45574000.0 14245000.0 26159000.0 5170000.0 True False 11845348.660500016 26018076.274845038 6251023.096620849 1.0 2.1964804093615227 0.5277196371150954 23.497817328249482 -6.71426167760814 1.78007144535594 1.7323459942755872 0.5311356515098045 0.48530024676711103 0.503867933957687 0.3665679971972392 2.266733157341479 0.2250420692065676 0.568765313399247 1.9308045891934963e-07 6.71426167760814 -1.2012103427657828 AWVNQLETQTGEASK(ub)LPYDVTTEQALTYPEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AWVNQLETQTGEASKLPYDVTTEQALTYPEVK 32 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 1 37927000.0 13515000.0 11051000.0 13361000.0 True False 20503243.078847896 9078862.70814291 10720192.49366567 1.0 0.4428013009078105 0.5228535043183057 24.28934878875794 -10.689472810697136 6.763984388796854 1.0041042560095121 0.4828274026132497 0.9823476688820713 0.032681175190200085 0.002030468784372122 9.321652080552457e-05 0.03176457614327808 0.010547803937177662 2.0442179116558434e-11 10.689472810697136 -0.5212768533962624 AWVNQLETQTGEASK(ub)LPYDVTTEQALTYPEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AWVNQLETQTGEASKLPYDVTTEQALTYPEVK 32 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 1 13920900.0 5967000.0 4637400.0 3316500.0 True False 4961824.882920577 4612417.405748175 4009964.8162365654 1.0 0.929580852727165 0.808163309035659 22.24243938859317 -6.962840112642766 0.39337706019778035 1.0071821048373122 0.7261757927867826 0.9998614405223001 0.0009326570166410293 0.07870188760824764 0.017494550980027435 0.0015650589815813453 0.010199078627951316 1.0893310613746707e-07 6.962840112642766 -0.2810063120505296 AWVNQLETQTGEASK(ub)LPYDVTTEQALTYPEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AWVNQLETQTGEASKLPYDVTTEQALTYPEVK 32 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 1 33024000.0 13515000.0 9629300.0 9879700.0 True False 17495433.920478206 9093420.990165005 8081695.974282584 1.0 0.5197596716661745 0.4619317252156319 24.06047511085039 -13.999999999999998 0.29861960076985017 5.346027046388376 0.44749864217325186 0.9996467492920053 0.004532888828567929 16.499048295269688 0.17350814571536843 44.269969908960995 0.021023458052502407 1.0000000000000041e-14 13.999999999999998 -4.898528404215124 AWVWNTHADFADECPKPELLAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AWVWNTHADFADECPKPELLAIR 23 1 P43487-2;P43487;F6WQW2;C9JXG8;C9JJ34;C9JGV6 P43487-2 RANBP1 Ran-specific GTPase-activating protein 0 55341800.0 8796900.0 37639000.0 8905900.0 False True 13345540.4395351 30922026.37515076 7145644.961405369 1.0 2.3170306601856843 0.5354331653918613 23.669854394093804 -6.708704432569241 1.7999841782718664 1.8107749572989025 0.5398156671801635 0.45881559459910115 0.5551065565142159 0.3777168999095734 2.3847767087989724 0.24550134612823651 0.6246329962668277 1.9556699716399228e-07 6.708704432569241 -1.270959290118739 AWVWNTHADFADECPKPELLAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AWVWNTHADFADECPKPELLAIR 23 1 P43487-2;P43487;F6WQW2;C9JXG8;C9JJ34;C9JGV6 P43487-2 RANBP1 Ran-specific GTPase-activating protein 0 22553600.0 8796900.0 6273700.0 7483000.0 False True 11387760.462823128 5924563.079974479 6121170.7820638735 1.0 0.5202570864847403 0.5375219124117737 23.440980716186253 -10.009957998212894 7.44003246511782 1.0000000202851513 0.5288894994650776 0.998993756314774 0.007048335669867782 2.37725609416285e-09 3.007047006820911e-10 0.006824521972048363 0.0022748405556564343 9.773317367654787e-11 10.009957998212894 -0.47111052082007376 AYAALAALEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYAALAALEK 10 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 34585000.0 10679000.0 11108000.0 12798000.0 False True 14000272.415583123 9450729.698644862 11473785.727084594 1.0 0.6750389862504137 0.8195401765406792 23.738951563438007 -10.120401369851978 4.985699765296172 1.0000104041940783 0.7472895813947483 0.8030702389440937 0.058992363908760434 6.822582021909304e-06 1.203735568468669e-06 0.057121461256503775 0.019039703580607456 7.578768304166172e-11 10.120401369851978 -0.25272082279932995 AYAALAALEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYAALAALEK 10 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 16329100.0 5828300.0 3459300.0 7041500.0 False True 5643283.806750128 4840616.530011181 5197119.909528033 1.0 0.8577659206544159 0.9209389581490792 22.428103475400334 -10.131277680844526 4.432166477760864 1.0000144811833855 0.8893524393978792 0.8035492768331499 0.025790284585123554 5785546.147513399 13224903.964602586 508.96446010988853 0.008828698752634303 7.391325345941763e-11 10.131277680844526 -0.11066204178550632 AYAALAALEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYAALAALEK 10 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 41876800.0 5019400.0 31162000.0 5695400.0 False True 7614796.767293303 25600897.63018269 4569701.693617504 1.0 3.3619935518361297 0.6001081622092739 22.86037410219817 -6.680200105096043 1.9008987193866524 2.494090447963076 0.610467937274304 0.32534377711531737 1.001004376324178 0.43796181501305004 3.059780758871504 0.42249516857217767 1.1141304155813314 2.0883336905782648e-07 6.680200105096043 -1.8836225106887718 AYAALAALEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYAALAALEK 10 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 29001600.0 10679000.0 8204600.0 10118000.0 False True 14627314.889123833 7842093.6430160105 7728336.786751051 1.0 0.536126671399343 0.5283496557866181 23.8021616249609 AYAALAALEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYAALAALEK 10 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 13990300.0 5828300.0 5355300.0 2806700.0 False True 4846489.687468742 5326449.935956175 3393567.993285442 1.0 1.099032553340294 0.700211537034727 22.20850875083461 -6.840995244958569 1.2779025875026633 1.052675787329063 0.6868447850763899 0.9261293358948918 0.04608350470608253 0.1676411176291947 0.5313798132410678 0.028273543859172152 0.06515009689031974 1.4421311411700753e-07 6.840995244958569 -0.3658310022526732 AYAALAALEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYAALAALEK 10 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 17925900.0 5019400.0 7443900.0 5462600.0 False True 6497712.247165978 7029640.421286007 4468462.851009243 1.0 1.0818639166965318 0.6876978667312013 22.631500424290618 -6.852523236495982 1.222849175789134 1.0437984597602454 0.6711563986794885 0.9438980437005465 0.04022731907013838 0.15470282311877312 0.4439011750276066 0.025723687930322398 0.0596302925893205 1.4043545429693312e-07 6.852523236495982 -0.3726420610807569 AYADSYYYEDGGMK(ub)PR ddPTM_RPMI8226_Bortezomib_1h_R1 2 AYADSYYYEDGGMKPR 16 1 Q8IVM0 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 46485600.0 18771100.0 17496100.0 10218400.0 True False 24609093.879590966 14885750.079263654 9161097.989814145 1.0 0.6048881828846546 0.3722647422387099 24.552688202158475 -9.097648157163507 0.15423008606700492 1.5083772996321416 1.6308682992914514e-19 0.9998173895724283 0.0035015435889345064 0.5514043675493828 0.05198913951958625 0.2998782359618507 0.17061739394128922 7.986414430726547e-10 9.097648157163507 -1.5083772996321416 AYADSYYYEDGGMK(ub)PR ddPTM_RPMI8226_Bortezomib_2h_R1 2 AYADSYYYEDGGMKPR 16 1 Q8IVM0 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 76474000.0 18445900.0 21711500.0 36316600.0 True False 17860345.00127518 30381015.173976783 26804192.985353407 1.0 1.7010318205951598 1.5007656897691315 24.09025661291376 -10.145586279468937 4.646669130926097 0.9999356390748602 1.6008987551898337 0.92310064025901 0.08175830557383758 57167712.68655352 4.850668255523761 39367.017781073686 0.027988042637428195 7.151772986772799e-11 10.145586279468937 0.6009631161149736 AYADSYYYEDGGMK(ub)PR ddPTM_RPMI8226_Bortezomib_8h_R1 2 AYADSYYYEDGGMKPR 16 1 Q8IVM0 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 269543000.0 45242000.0 112233000.0 112068000.0 True False 68635421.6332398 92204144.26956864 89917710.6788506 1.0 1.343390075787261 1.3100773411043474 26.032449984424915 -10.060407505300901 4.461041343684416 0.9999791370969329 1.326733708472496 0.9922639150005095 0.013599867071097081 7128087.099175994 0.06998812846957102 1539.0712717421159 0.004977041711346783 8.70146734499498e-11 10.060407505300901 0.3267545713755631 AYADSYYYEDGGMK(ub)PR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AYADSYYYEDGGMKPR 16 1 Q8IVM0 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 49016000.0 18771100.0 13879700.0 16365200.0 True False 25711282.939903732 13266448.959969942 12500076.811873715 1.0 0.5159777126243866 0.4861708706286952 24.615898263681366 -13.999999999999993 0.3964900939177333 8.977299140868867 0.48427526715061664 0.9998327455370276 0.0030457776374806077 26.258675226223705 0.20711764409018787 179.97198288237718 0.007701613357839702 1.0000000000000164e-14 13.999999999999993 -8.49302387371825 AYADSYYYEDGGMK(ub)PR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AYADSYYYEDGGMKPR 16 1 Q8IVM0 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 74205100.0 18445900.0 36723100.0 19036100.0 True False 15338583.141924683 36525265.37133535 23016460.497018225 1.0 2.3812672287508403 1.5005597507965214 23.870661888348035 -10.263190377192474 5.4142333373820115 0.999903563448629 1.9409134897736682 0.6034673131538602 0.35954732227380537 0.0004186292962953129 5.696960021186886e-05 0.3481653689482802 0.11604339927829556 5.4551867527549745e-11 10.263190377192474 0.9410099263250392 AYADSYYYEDGGMK(ub)PR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AYADSYYYEDGGMKPR 16 1 Q8IVM0 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 285489500.0 45242000.0 153022500.0 87225000.0 True False 58566660.85314647 144506663.3574119 71350945.00407882 1.0 2.467387780904165 1.2182860344896291 25.803576306517364 -6.606870207451987 2.1650427457593673 1.9824301020349127 1.2226233348257225 0.040748228229977035 0.6331465905724613 0.6214474491298002 5.515207107844248 0.24186688291150818 0.7033853862626879 2.472462950899e-07 6.606870207451987 -0.7598067672091902 AYCHILLGNYCVAVADAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYCHILLGNYCVAVADAK 18 0 Q9Y2Z0;Q9Y2Z0-2 Q9Y2Z0 SUGT1 Suppressor of G2 allele of SKP1 homolog 0 32891800.0 6797800.0 14816000.0 11278000.0 False True 10312759.585748583 12171969.042063648 9048898.356676988 1.0 1.180282439521265 0.87744684450725 23.297927098562354 -6.745455808251565 1.6666375373118087 1.1065876156241414 0.8770480779920811 0.6291303725128895 0.07574543483646828 0.30807393219366697 1.682151203155367 0.03592419354775803 0.08763525576839015 1.7969839234391697e-07 6.745455808251565 -0.22953953763206036 AYCHILLGNYCVAVADAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYCHILLGNYCVAVADAK 18 0 Q9Y2Z0;Q9Y2Z0-2 Q9Y2Z0 SUGT1 Suppressor of G2 allele of SKP1 homolog 0 24924600.0 6797800.0 12574000.0 5552800.0 False True 8799886.104670858 11874245.846565664 4542247.376539397 1.0 1.3493635832698991 0.5161711552298881 23.069053420654804 -6.7928083234963585 1.4851522138109645 1.194547198397171 0.5066182593673754 0.8102840071579177 0.14879856625798699 0.23118681801789345 1.0072921497653808 0.0788507485372948 0.18423381124731134 1.611356652873645e-07 6.7928083234963585 -0.6879289390297956 AYCSILYLKPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYCSILYLKPR 11 1 Q14149 Q14149 MORC3 MORC family CW-type zinc finger protein 3 0 10672700.0 3827100.0 2951600.0 3894000.0 False True 5017365.1616891185 2511232.7852466903 3491086.2338855644 1.0 0.5005082756227519 0.6958007084161031 22.258498509975077 -10.153999928096118 5.303754117371435 1.0000130943140677 0.5981544920192514 0.8495174431994384 0.07972780182903207 1.2345017526338133e-05 1.9690223009321023e-06 0.07719862593908249 0.025732037392708067 7.014554145562919e-11 10.153999928096118 -0.4018586022948163 AYCSILYLKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYCSILYLKPR 11 1 Q14149 Q14149 MORC3 MORC family CW-type zinc finger protein 3 0 9428100.0 3827100.0 2699700.0 2901300.0 False True 5242082.2934886925 2580418.3272859533 2216072.694149125 1.0 0.49225063301488964 0.422746643428654 22.321708571497968 -13.999999999999998 0.2802046837582452 5.142775479010593 0.4018650984667786 0.9996056305882085 0.005109787049671175 15.409394951497207 0.16768880218972534 36.58698021871921 0.027467338380555966 1.0000000000000041e-14 13.999999999999998 -4.740910380543815 AYCVLVTGPNMGGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 AYCVLVTGPNMGGK 14 0 P52701;A0A494C0M1;P52701-3;P52701-4 P52701 MSH6 DNA mismatch repair protein Msh6 0 27474200.0 9316100.0 7640100.0 10518000.0 False True 12213497.317240736 6500226.860876546 9429698.25578026 1.0 0.5322166691518194 0.7720719144441266 23.541973037327676 -10.506977637122 7.586390591471976 1.0000632609826097 0.6521442917979817 0.7371458395273642 0.09792049384937493 0.00010479194657279975 6.810205706602797e-06 0.09482823675516311 0.031603703494252906 3.111876571065569e-11 10.506977637122 -0.34791896918462795 AYCVLVTGPNMGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYCVLVTGPNMGGK 14 0 P52701;A0A494C0M1;P52701-3;P52701-4 P52701 MSH6 DNA mismatch repair protein Msh6 0 16352200.0 2841400.0 7668500.0 5842300.0 False True 4310611.534164883 6299996.260736033 4687566.844228939 1.0 1.4615087002862028 1.0874482209951877 22.039461124188986 -10.152092864106981 5.495730287684204 0.9999939932665288 1.2744784606407427 0.4178982361280874 0.15270955120081697 1.1239302588932301e-05 1.7340102651957022e-06 0.14786362298711334 0.04928679571727357 7.045424023129282e-11 10.152092864106981 0.27448446737421384 AYCVLVTGPNMGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYCVLVTGPNMGGK 14 0 P52701;A0A494C0M1;P52701-3;P52701-4 P52701 MSH6 DNA mismatch repair protein Msh6 0 17909300.0 7549800.0 4107300.0 6252200.0 False True 10341165.085673464 3925825.9049752178 4775559.1281009 1.0 0.3796309093270364 0.4618008791598257 23.301895400022282 -10.664227459289183 6.691329426819705 1.0032819119824943 0.4207158942442557 0.9851338150101068 0.033545749711703425 0.0016474839173831232 8.267106192773748e-05 0.032581091406981885 0.010826844164122468 2.1665690792597116e-11 10.664227459289183 -0.5825660177382386 AYDASLAMLMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYDASLAMLMR 11 0 Q9NR50;Q9NR50-3;Q9NR50-2 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 0 4404480.0 653380.0 1959800.0 1791300.0 False True 856587.5073409203 1667405.479240567 1605953.459362919 1.0 1.9465675893600707 1.8748270849153914 19.708241111239982 -10.11803265199035 5.409132984659568 0.9999845587522892 1.9106973371381002 0.9953673935339182 0.029287938297854397 5.4540583819555435e-06 8.893577523618523e-07 0.028358404129389662 0.009452641439173739 7.620217160414347e-11 10.11803265199035 0.910712778385811 AYEFLCTK(ub)SAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYEFLCTKSAK 11 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 31880700.0 9225100.0 10660700.0 11994900.0 True False 12094195.43599547 9070165.115083128 10753782.811205437 1.0 0.7499601906620392 0.8891689296833573 23.52781146171395 -10.119076539537426 4.859853863538011 1.000009444137324 0.819564560289768 0.6913587124163212 0.05683172972678879 5.815697339165676e-06 1.0541208064581829e-06 0.055029965733302225 0.018342361896806776 7.601922897583375e-11 10.119076539537426 -0.18044488384755597 AYEFLCTK(ub)SAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYEFLCTKSAK 11 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 21436400.0 10822100.0 5336100.0 5278200.0 True False 10478558.35921804 7466832.557393887 3895681.0773941446 1.0 0.712582046253078 0.37177643563602375 23.320936908656257 -6.968869292034152 0.2838957302977273 1.0716452445352072 0.002272480493449764 0.9999721705516571 0.0013545937394006994 0.07667132213050114 0.010337223770437724 0.006157138676049361 0.031130791350230655 1.0743126955144435e-07 6.968869292034152 -1.0693727640417574 down AYEFLCTK(ub)SAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYEFLCTKSAK 11 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 13778600.0 7605000.0 3344000.0 2829600.0 True False 11537340.999973219 2747237.0732087493 2270328.319742263 1.0 0.2381170040146275 0.1967808977603707 23.45980742994774 -13.498474904489658 0.4197269972323788 9.999899978953367 0.19538058413952977 0.9998556422251248 0.004436904487720102 19.27533142759599 0.2154898310234972 156.6382946583699 0.010040064149442982 3.1734020321402604e-14 13.498474904489658 -9.804519394813838 AYEFLCTK(ub)SAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYEFLCTKSAK 11 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 33574200.0 9225100.0 9782200.0 14566900.0 True False 12635868.768953651 9349990.058590462 11126498.234722678 1.0 0.7399562491154864 0.8805487329894167 23.59102152323684 -10.06671825374746 4.736425054264907 1.0000072070386328 0.8102524911970804 0.708340853842175 0.05739664120619709 4.3683303067121326e-06 8.607167904353065e-07 0.05557616946013292 0.018524686291534264 8.575940243978929e-11 10.06671825374746 -0.18975471584155235 AYEFLCTK(ub)SAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYEFLCTKSAK 11 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 22271100.0 10822100.0 2877100.0 8571900.0 True False 8999055.650319207 2861600.4912403664 10364244.658012446 1.0 0.31798897600315007 1.1517035854361912 23.101342184090534 -6.6892479731693815 1.868871147119384 0.5721230037401759 1.1488119806873363 0.3669700756923968 0.28848684492555404 0.4183071317365171 2.832002983915011 0.12351007833919338 0.32195976290403827 2.0452764926756523e-07 6.6892479731693815 0.5766889769471604 AYFETEK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYFETEKK 8 1 P15170-2;P15170-3;P15170;H3BR35;H3BSV8 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 1 3775100.0 1078800.0 1502300.0 1194000.0 True False 1414317.24711406 1278162.6959195344 1070456.333656745 1.0 0.9037312516181562 0.756871441567322 20.4316743383412 -6.964975536110424 0.35847529512069265 1.0128773859851499 0.6427045195932332 0.9999126329927895 0.000934409959208167 0.07796929370641469 0.014889451745066043 0.0019765602301404527 0.01255521188793355 1.0839879735471872e-07 6.964975536110424 -0.3701728663919167 AYFETEK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYFETEKK 8 1 P15170-2;P15170-3;P15170;H3BR35;H3BSV8 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 1 9565700.0 1536600.0 2232600.0 5796500.0 True False 2331134.540507412 1834175.0866165839 4650819.234303796 1.0 0.786816485597328 1.9950882943424895 21.152600840767146 -6.861326813827552 1.1789192244403206 0.8838921570831466 2.0551251651266687 0.9552387897195689 0.11140749752017239 0.14544643838233487 0.38335543853818044 0.07366103370364521 0.17222267583752943 1.3761734856876941e-07 6.861326813827552 1.171233008043522 AYFETEK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYFETEKK 8 1 P15170-2;P15170-3;P15170;H3BR35;H3BSV8 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 1 3115110.0 1078800.0 1041200.0 995110.0 True False 1477661.513473805 995196.3412120364 760085.5129337658 1.0 0.6734941203634986 0.5143840493936233 20.49488439986409 -13.999999999981787 0.09449510611936746 2.6420191437796974 0.14460154052146157 0.9998209271964096 0.002704991687399152 12.12459044875142 0.09038569563716484 3.941951561594949 0.33100394223163454 1.000000000041937e-14 13.999999999981787 -2.497417603258236 AYFETEK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYFETEKK 8 1 P15170-2;P15170-3;P15170;H3BR35;H3BSV8 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 1 7892200.0 1536600.0 1745200.0 4610400.0 True False 1989158.9909143036 1648078.085845907 3771354.5066988254 1.0 0.8285300940617014 1.8959542821488329 20.923727162859596 -6.865745887538187 1.156289401582675 0.9051098933733562 1.953633689870846 0.9602538530164539 0.09330995947718444 0.14100310678706426 0.3550141010107061 0.06277381839133168 0.14762444225978982 1.3622415180403237e-07 6.865745887538187 1.0485237964974896 AYFHLLNQIAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYFHLLNQIAPK 12 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3;H7C4N2;Q14651;C9JAM8 P13797;Q14651 PLS3;PLS1 Plastin-3;Plastin-1 0 112312800.0 34247800.0 35645000.0 42420000.0 False True 44899197.45616693 30326904.94312173 38030785.32137282 1.0 0.6754442542704361 0.8470259487043297 25.42018632217672 -10.03197002881008 4.804263051854718 1.000005337030701 0.7612351023416986 0.7208178055286897 0.07004793344438723 18070168.91384991 37733026.780893594 618.0282580577891 0.023979273263636348 9.290304980912747e-11 10.03197002881008 -0.23877023468900238 AYFHLLNQIAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYFHLLNQIAPK 12 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3;H7C4N2;Q14651;C9JAM8 P13797;Q14651 PLS3;PLS1 Plastin-3;Plastin-1 0 123950300.0 38696000.0 21224300.0 64030000.0 False True 37467616.6611195 29699273.6732623 47258622.14117446 1.0 0.7926651417911382 1.2613191431045887 25.159140874049854 -6.786423964439014 1.5103934234006926 0.8835800632643463 1.2658377839988437 0.7895952905562227 0.08795544659655265 0.24072184853720494 1.08487489353094 0.04584467422457609 0.10762888564623861 1.635219417585883e-07 6.786423964439014 0.3822577207344974 AYFHLLNQIAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYFHLLNQIAPK 12 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3;H7C4N2;Q14651;C9JAM8 P13797;Q14651 PLS3;PLS1 Plastin-3;Plastin-1 0 56546000.0 16040000.0 24332000.0 16174000.0 False True 24333852.681074355 19989764.493216284 12977201.81068395 1.0 0.8214796380666558 0.5332982812366972 24.536461418678165 -6.96400877478349 0.3746822976207457 1.0210177639709725 0.3236548753303093 0.9998912204123837 0.0020053752754562743 0.07829905330289587 0.016056455291187693 0.003773563390391067 0.024415145385778065 1.0864036729506041e-07 6.96400877478349 -0.6973628886406633 AYFHLLNQIAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYFHLLNQIAPK 12 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3;H7C4N2;Q14651;C9JAM8 P13797;Q14651 PLS3;PLS1 Plastin-3;Plastin-1 0 121175600.0 34247800.0 32632100.0 54295700.0 False True 46910137.17199496 31190305.922075722 41472173.91504242 1.0 0.6648947925203708 0.8840770122454691 25.48339638369961 -10.157557862219672 4.9429420066189955 1.000015453649761 0.7744859023823442 0.5853173237457635 0.0894807665048389 1.5239746198758746e-05 2.5973284265449527e-06 0.08664531334202079 0.02887979320630835 6.957322542494749e-11 10.157557862219672 -0.2255295512674168 AYFHLLNQIAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYFHLLNQIAPK 12 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3;H7C4N2;Q14651;C9JAM8 P13797;Q14651 PLS3;PLS1 Plastin-3;Plastin-1 0 99188000.0 38696000.0 25862100.0 34629900.0 False True 32177438.52346144 25722775.734075107 41870851.97943336 1.0 0.7994040829359347 1.3012487600249532 24.93954614948413 -6.798255767908078 1.4632730096404283 0.8890760372988222 1.3078619939843463 0.8269394601091193 0.0857995626052479 0.2232610053262306 0.9439777320570123 0.04613465467717598 0.10739634315033385 1.5912713078122446e-07 6.798255767908078 0.4187859566855241 AYFHLLNQIAPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYFHLLNQIAPK 12 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3;H7C4N2;Q14651;C9JAM8 P13797;Q14651 PLS3;PLS1 Plastin-3;Plastin-1 0 78681700.0 16040000.0 38118500.0 24523200.0 False True 20764096.195669267 35997171.96614554 20060229.2292809 1.0 1.7336257560612442 0.9661017286880432 24.307587740770614 -6.656398682451025 1.9855014670318385 1.4736133883111278 0.9693059795146279 0.22048550357903152 0.31263083211321596 0.49303487175490207 3.732419449314059 0.12737689278922826 0.34648186045994445 2.2059787141661957e-07 6.656398682451025 -0.5043074087964998 AYFHVTCAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYFHVTCAQK 10 0 B4DG57;A0A0U1RRH6;O94880-2;O94880 B4DG57 PHF14 PHD finger protein 14 0 3439640.0 922640.0 1044200.0 1472800.0 False True 1209589.97485847 888409.430259721 1320408.784095187 1.0 0.7344715554241186 1.0916168383833402 20.206086656917503 -6.707599587490816 1.8035736397412767 0.8363633605824254 1.0907271000389187 0.45379682001014987 0.11193480439693941 0.3799123599194026 2.4074327399365387 0.049415232497865315 0.12591352075775908 1.9606515295260583e-07 6.707599587490816 0.25436373945649327 AYFHVTCAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYFHVTCAQK 10 0 B4DG57;A0A0U1RRH6;O94880-2;O94880 B4DG57 PHF14 PHD finger protein 14 0 2850680.0 922640.0 1061200.0 866840.0 False True 1263764.9414084842 1014312.6750808808 662110.2451301918 1.0 0.8026118163638997 0.5239188265440093 20.269296718440394 -6.966243565941865 0.33602616597415336 1.0316541724158255 0.2856701913844452 0.9999365312421006 0.0015559056960198071 0.07754146831397457 0.01338573039060695 0.003983824246779498 0.024193744455875493 1.0808276193225751e-07 6.966243565941865 -0.7459839810313802 AYFLGYMVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYFLGYMVHR 10 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 6204800.0 1778700.0 2518900.0 1907200.0 False True 2331892.9249553047 2143089.9385952963 1709861.239154223 1.0 0.9190344529375734 0.7332503224550911 21.153070114216558 -6.957271680704403 0.47232015019645884 1.0047980495908297 0.6398406982799146 0.9996552296588608 0.0020734321308486826 0.08069057830149155 0.02484483201495705 0.002580100150290846 0.015331385872325737 1.1033881597016096e-07 6.957271680704403 -0.3649573513109151 AYFLGYMVHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYFLGYMVHR 10 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 5135120.0 1821600.0 708320.0 2605200.0 False True 1763774.3050934286 991155.8698400019 1922819.9656752744 1.0 0.561951643686917 1.0901734763470323 20.750234532853252 -6.686536702112349 1.8786392232538836 0.7244803461486025 1.0882773985071414 0.3542276394972006 0.18539691910674355 0.42419876269008194 2.8998381483915985 0.07902706586192004 0.2067011800116956 2.0580849549747262e-07 6.686536702112349 0.363797052358539 AYFLGYMVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYFLGYMVHR 10 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 7273600.0 1778700.0 2126600.0 3368300.0 False True 2436333.457560124 2032639.780274219 2572776.9123160266 1.0 0.8343027814878077 1.0560036042408352 21.21628017573945 -6.706664829892739 1.8073892169608496 0.8977872824420357 1.0554271505616868 0.44916381864222366 0.06986133437098323 0.3817928905255742 2.429104063341576 0.030786525640962237 0.07852152622295293 1.9648761000819202e-07 6.706664829892739 0.15763986811965114 AYFLGYMVHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYFLGYMVHR 10 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 7524700.0 0.0 4339300.0 3185400.0 False True 0.0 4097814.1404487337 2605689.8849640912 0.0 AYFMQLQTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYFMQLQTR 9 0 Q9Y2Y1 Q9Y2Y1 POLR3K DNA-directed RNA polymerase III subunit RPC10 0 10017500.0 2367100.0 3194000.0 4456400.0 False True 3103291.0230290093 2717467.650114487 3995294.476807299 1.0 0.8756728356923695 1.287437899687422 21.56536756680094 -6.825724985583594 1.3468668633887764 0.9333469604203173 1.2975841920198208 0.897058698010614 0.05532730996037184 0.18614557916249821 0.6618863267712425 0.03226627073203621 0.07428201429737465 1.4937400121918047e-07 6.825724985583594 0.3642372315995035 AYFMQLQTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYFMQLQTR 9 0 Q9Y2Y1 Q9Y2Y1 POLR3K DNA-directed RNA polymerase III subunit RPC10 0 4767700.0 2064400.0 1216100.0 1487200.0 False True 1716640.0684265513 1209548.6279230495 1798166.6439641253 1.0 0.7046023509352809 1.0474919448969289 20.711156147434956 -6.678776100005564 1.906372937344143 0.8128894895686387 1.0461694632553833 0.31843138413610783 0.12523091664393252 0.44127121911593886 3.0995535250142243 0.05273304222819024 0.13929132242248904 2.0951923513380912e-07 6.678776100005564 0.23327997368674458 AYFQQYGCTFTAVIPTNVFGPHDNFNIEDGHVLPGLIHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYFQQYGCTFTAVIPTNVFGPHDNFNIEDGHVLPGLIHK 39 0 Q13630;E9PKL9;E9PP14;A0A0J9YX13 Q13630 TSTA3 GDP-L-fucose synthase 0 289829000.0 100509000.0 83850000.0 105470000.0 False True 152479501.1921511 68886312.37695974 84623808.2708568 1.0 0.45177425056074144 0.554984818347588 27.18404006396315 -9.925434843405576 5.727428928387553 1.0000003479597814 0.5033795344538059 0.9686227382634681 0.04213553785868651 1.8724093362869392e-07 3.513364327586658e-08 0.04079758767359378 0.013599186367238274 1.1873128185654343e-10 9.925434843405576 -0.49662081350597553 AYFQQYGCTFTAVIPTNVFGPHDNFNIEDGHVLPGLIHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYFQQYGCTFTAVIPTNVFGPHDNFNIEDGHVLPGLIHK 39 0 Q13630;E9PKL9;E9PP14;A0A0J9YX13 Q13630 TSTA3 GDP-L-fucose synthase 0 168395000.0 100509000.0 26650000.0 41236000.0 False True 130110881.82858625 25166904.07276725 33731471.11709025 1.0 0.19342658906826277 0.25925172931753365 26.9551663860556 -10.823420448755204 10.79077472545751 1.009618790301029 0.22633915919289999 0.9946000206041992 0.02687300097630886 0.005955677818837604 9.74581253138649e-05 0.024919629139415537 0.00867322377032166 1.5016874499246867e-11 10.823420448755204 -0.7832796311081289 AYGASK(ub)TFGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYGASKTFGK 10 1 P27694 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 2875560.0 856760.0 1123200.0 895600.0 True False 829562.6227667135 1571699.61741062 661015.492575916 1.0 1.894612382810559 0.7968241027679526 19.661991367184985 -6.690053567514978 1.866664705863769 1.5608461673940806 0.8006596094938024 0.3705290454163386 0.378354657677163 0.4165250498473025 2.814079043285313 0.1621637358329126 0.4221887545191027 2.0414861245620634e-07 6.690053567514978 -0.7601865579002781 AYGASK(ub)TFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYGASKTFGK 10 1 P27694 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 2987260.0 856760.0 1821600.0 308900.0 True False 712433.900903474 1811786.6792407106 373489.5618077721 1.0 2.543094421732446 0.5242445107316354 19.44239664261926 -6.702427093893382 1.8221013430632298 1.9559033026587178 0.5299457338249971 0.42915833518515356 0.6510735641361598 0.3904938729552151 2.522127939490112 0.28487541618848966 0.7304680709426851 1.9841427119060787e-07 6.702427093893382 -1.4259575688337207 AYGELPEHAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYGELPEHAK 10 0 O14602;A6NJH9;P47813;X6RAC9 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 0 8923620.0 2468200.0 947120.0 5508300.0 False True 2389848.342024374 1325309.9551655515 4065510.9845421077 1.0 0.5545581834046082 1.7011585685384232 21.188487638094415 -6.801350817820205 1.450331790044928 0.7546489090974113 1.7175306979293157 0.8361009511815621 0.19107125697571506 0.2188336613053286 0.9086075047003889 0.10363375536162679 0.2408247298603391 1.5799712420240907e-07 6.801350817820205 0.9628817888319043 AYGFSCDGEGVLK(ub)FAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYGFSCDGEGVLKFAR 16 1 U3KQ85;Q99622 U3KQ85 C12orf57 Protein C10 1 23181100.0 6558400.0 7072100.0 9550600.0 True False 9949572.283264233 5810028.500430493 7662919.723823321 1.0 0.5839475642790498 0.7701757930552254 23.2462030770833 -10.007259198273955 4.659191582159381 1.000007255553487 0.6770616786509546 0.8003780494883697 0.076027356092924 52435670.43629195 2.2074338515898377 4304.29967855818 0.02602618619089206 9.834239974866882e-11 10.007259198273955 -0.32294557690253234 AYGFSCDGEGVLK(ub)FAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYGFSCDGEGVLKFAR 16 1 U3KQ85;Q99622 U3KQ85 C12orf57 Protein C10 1 19122700.0 6558400.0 4444700.0 8119600.0 True False 8489978.085391367 4197348.53779469 6641916.114131481 1.0 0.49438861862518013 0.7823242942829464 23.01732939917575 -10.186919811600935 5.587567217387718 1.0000103547712733 0.6383564564540403 0.6777663999502186 0.11754924735092946 1.5163421760194345e-05 2.2064920558170417e-06 0.11381982535328136 0.037938856445767576 6.502497417700446e-11 10.186919811600935 -0.36165389831723305 AYGGSMCAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYGGSMCAK 9 0 P49207 P49207 RPL34 60S ribosomal protein L34 0 9221100.0 1050500.0 4628300.0 3542300.0 False True 1377215.6730564728 3937775.680972099 3175776.7761409394 1.0 2.85922950051312 2.3059400486583894 20.393323073666007 -10.04855111257801 5.029878107099249 0.9999758047364055 2.5825847745878474 0.9160268787538629 0.22587947288567303 6.566575220815117e-05 1.2421785036742098e-05 0.21871042043597824 0.07290228638976627 8.942292829468829e-11 10.04855111257801 1.5826089698514418 AYGGSMCAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYGGSMCAK 9 0 P49207 P49207 RPL34 60S ribosomal protein L34 0 6279100.0 1050500.0 2254200.0 2974400.0 False True 1438898.238695064 2154601.9903574423 2271907.97969088 1.0 1.4973970586769565 1.578921926926029 20.4565331351889 -11.73406484310102 0.30189820991344685 1.0271960961937693e-12 1.6008385098440001 0.9994297434956199 0.006110057755974919 4.48441828723984 0.16320268550874287 2.89046874429904 0.029182702313453657 1.8447399664731456e-12 11.73406484310102 1.600838509842973 AYGGSMCAK(ub)CVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYGGSMCAKCVR 12 1 P49207 P49207 RPL34 60S ribosomal protein L34 1 7927300.0 638900.0 1285800.0 6002600.0 True False 837604.0871164018 1093963.6520091437 5381508.533005008 1.0 1.306062934548594 6.424883325882267 19.67590895640011 -6.91915185255971 0.830992769632099 0.8835666414709984 7.234448396406503 0.9939420565932895 0.19367241860836235 0.09867344947653768 0.10821911031711055 0.1661233870806559 0.4936547209362214 1.2046146690633082e-07 6.91915185255971 6.3508817549355046 up AYGGSMCAK(ub)CVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYGGSMCAKCVR 12 1 P49207 P49207 RPL34 60S ribosomal protein L34 1 2686770.0 983700.0 720410.0 982660.0 True False 952472.981950156 1008073.4698885209 725271.8668318995 1.0 1.0583748715102919 0.7614618793143403 19.861318643830845 -6.855652402465454 1.2074092803936975 1.0313759863304401 0.7482265409284261 0.9481426156371512 0.0292480318048123 0.15135048075732307 0.42175143495022804 0.018923129939988882 0.04398068748147697 1.3942722942427465e-07 6.855652402465454 -0.28314944540201403 AYGGSMCAK(ub)CVR ddPTM_RPMI8226_Bortezomib_8h_R1 2 AYGGSMCAKCVR 12 1 P49207 P49207 RPL34 60S ribosomal protein L34 1 28888800.0 1970100.0 6366400.0 20552300.0 True False 2988785.73360253 5230266.17908976 16490128.896606889 1.0 1.7499635789499919 5.517333916316085 21.51112804307178 -6.93970103523239 0.6623383181598385 0.9574879164344956 6.524402982829895 0.9981244885974387 0.08560011256377277 0.0879032738118044 0.055232610995652465 0.08313777166514544 0.32467945526513964 1.1489442731626893e-07 6.93970103523239 5.566915066395399 AYGGSMCAK(ub)CVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYGGSMCAKCVR 12 1 P49207 P49207 RPL34 60S ribosomal protein L34 1 11571870.0 638900.0 994570.0 9938400.0 True False 875118.5956232994 950626.6087968259 7591154.607772946 1.0 1.0862831775614896 8.674429552449608 19.739119017923002 -6.909383802576899 0.8999188386430597 0.7604524527840965 9.642260491035158 0.990686989924327 0.34718219121548205 0.1048269780872901 0.1409872114118005 0.2833794887389616 0.7789578510819543 1.2320155728973988e-07 6.909383802576899 8.88180803825106 up AYGGSMCAK(ub)CVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYGGSMCAKCVR 12 1 P49207 P49207 RPL34 60S ribosomal protein L34 1 16003000.0 1210600.0 4744400.0 10048000.0 True False 1567145.5644935924 4480369.9693372175 8219367.1011863975 1.0 2.8589367004876824 5.244801304620611 20.579707760251168 -6.967718335025391 0.30784569773006076 0.6229605661545121 7.556381589360141 0.9999587190359076 0.011162696534216511 0.07705020890105907 0.01166645258060411 0.0381224338972205 0.21226623732997424 1.0771635897389404e-07 6.967718335025391 6.933421023205629 AYGK(ub)SEWNTVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYGKSEWNTVER 12 1 B5MCF9;O00541-2;O00541 B5MCF9 PES1 Pescadillo homolog 1 7023100.0 1935300.0 1800100.0 3287700.0 True False 1873864.96082966 2518889.31739749 2426552.741114154 1.0 1.3442213660274875 1.2949453625728662 20.837585558948263 -10.086604739734195 4.472404334425414 0.9999744121651601 1.3195833642883306 0.9824818411703968 0.020116844235860364 13984490.260201044 0.08849594037389749 3783.681527238701 0.006886530848967863 8.192100287096754e-11 10.086604739734195 0.3196089521231704 AYGK(ub)SEWNTVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYGKSEWNTVER 12 1 B5MCF9;O00541-2;O00541 B5MCF9 PES1 Pescadillo homolog 1 11306600.0 2349200.0 2994300.0 5963100.0 True False 3563908.149524935 2459943.7704273183 4784490.671280421 1.0 0.6902377017643471 1.342484281453266 21.76502872494595 -6.777549409483065 1.5452998634354884 0.8240474775526717 1.3472703693771049 0.7586651680519594 0.130866439785219 0.25439953598027204 1.1997204861771644 0.06671133470482764 0.1577440427236812 1.6689779175608882e-07 6.777549409483065 0.5232228918244332 AYGK(ub)SEWNTVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYGKSEWNTVER 12 1 B5MCF9;O00541-2;O00541 B5MCF9 PES1 Pescadillo homolog 1 3623400.0 1142200.0 1132100.0 1349100.0 True False 1564502.2067943842 1082080.0786459344 1030470.3655866625 1.0 0.6916449679307787 0.6586570227331695 20.577272262884836 -13.999999999999998 0.3156991595437029 4.0821764472355495 0.6517889800438053 0.9996844458551336 0.0027307643902814457 17.68558859730306 0.17899988395301283 35.91971183506937 0.011170982232131418 1.0000000000000041e-14 13.999999999999998 -3.4303874671917445 AYGK(ub)SEWNTVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYGKSEWNTVER 12 1 B5MCF9;O00541-2;O00541 B5MCF9 PES1 Pescadillo homolog 1 5813600.0 1935300.0 2135600.0 1742700.0 True False 1609287.6983268268 2124095.0989165907 2107090.5126656033 1.0 1.3198976796535562 1.3093311499592901 20.61799083438254 -10.021876809721135 4.63753569002024 0.9999909083932043 1.3146144148223682 0.9991547166455133 0.004313767737953695 2979528.902047436 0.016371156117291775 291.30428035252936 0.0014767174280855338 9.508744767512403e-11 10.021876809721135 0.3146235064291639 AYGK(ub)SEWNTVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYGKSEWNTVER 12 1 B5MCF9;O00541-2;O00541 B5MCF9 PES1 Pescadillo homolog 1 10122500.0 2349200.0 1714800.0 6058500.0 True False 3041085.709655007 1619369.872569651 4955915.165459573 1.0 0.5324972812927916 1.6296532352657014 21.5361550470384 -6.790923050433774 1.4925656973708195 0.7390200479765129 1.641632566088471 0.8043090107408876 0.1988627449081095 0.2339864250706165 1.0297403211759393 0.1048641681626845 0.24535683680323853 1.6183667591959022e-07 6.790923050433774 0.9026125181119581 AYGQALAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYGQALAK 8 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 4252740.0 0.0 854540.0 3398200.0 False True 0.0 1195762.2783672307 2508109.476185213 0.0 AYGVCFVDTSLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYGVCFVDTSLGK 13 0 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 0 7999600.0 2210000.0 2407100.0 3382500.0 False True 2897331.401670443 2047970.062802309 3032511.347231105 1.0 0.7068470184741591 1.0466567081289786 21.466293281271753 -6.678467420068202 1.907406464891036 0.8142646509258369 1.045346507193982 0.31711922161945105 0.12428688341720417 0.4419199459130487 3.107187945708772 0.052311747759662616 0.13823646917559965 2.0966820634242707e-07 6.678467420068202 0.23108185626814515 AYGVCFVDTSLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYGVCFVDTSLGK 13 0 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 0 6444200.0 2210000.0 2320300.0 1913900.0 False True 3027096.7230043663 2217781.473793976 1461876.2380077941 1.0 0.7326430823765842 0.48293013794316264 21.529503342794644 -6.971947748871569 0.20642956988543057 1.1368442951985516 0.07178561396624837 0.9999938526875546 0.0005234486602164663 0.07567561332207272 0.006718974125582019 0.007694174932649941 0.026094397602794365 1.0667244539766653e-07 6.971947748871569 -1.0650586812323033 down AYHEQLSVAEITNACFEPANQMVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYHEQLSVAEITNACFEPANQMVK 24 0 P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2 P68363;P68366-2;Q71U36 TUBA1B;TUBA4A;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain 0 19107500.0 4316400.0 10722000.0 4069100.0 False True 5658842.200077061 9122319.394028667 3648068.565563362 1.0 1.6120469649965574 0.6446669542249621 22.432075476962133 -6.735721696744724 1.7022678251528907 1.3659594464320743 0.6446035452285788 0.5856108317882103 0.2571959026900237 0.32561986550625827 1.8509190471743382 0.1196087551193124 0.2949092992073582 1.8377156053701495e-07 6.735721696744724 -0.7213559012034956 AYHEQLSVAEITNACFEPANQMVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYHEQLSVAEITNACFEPANQMVK 24 0 P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2 P68363;P68366-2;Q71U36 TUBA1B;TUBA4A;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain 0 32939700.0 19097000.0 4083000.0 9759700.0 False True 18490776.18816929 5713363.1925637135 7203341.785275976 1.0 0.30898449769887 0.3895640568017256 24.140302450301363 -10.577482025631008 6.43781481581045 1.0012396683092677 0.3492742772558792 0.9886302996722971 0.03289646725007262 0.0005862386507062676 3.8475205648805236e-05 0.031901733987264334 0.010617289150715753 2.6455621857005075e-11 10.577482025631008 -0.6519653910533885 AYHEQLSVAEITNACFEPANQMVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYHEQLSVAEITNACFEPANQMVK 24 0 P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2 P68363;P68366-2;Q71U36 TUBA1B;TUBA4A;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain 0 29488400.0 4316400.0 5272000.0 19900000.0 False True 5912289.726324005 5039065.60782737 15200029.85336491 1.0 0.8523035644534345 2.570921006406025 22.495285538485025 -6.885990214402793 1.0457905983549765 0.8985867557791936 2.7076389662307014 0.9782060369923564 0.11480904595483582 0.12245772551860547 0.24132467042372807 0.08405597132942783 0.2067491922806088 1.3001988740056327e-07 6.885990214402793 1.8090522104515079 up AYHEQLSVAEITNACFEPANQMVK(ub)CDPR ddPTM_RPMI8226_Bortezomib_1h_R1 2 AYHEQLSVAEITNACFEPANQMVKCDPR 28 1 P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2 P68363;P68366-2;Q71U36 TUBA1B;TUBA4A;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain 1 148850200.0 75466600.0 51997600.0 21386000.0 True False 98937443.41959402 44239760.765057355 19173181.86899761 1.0 0.4471488168279868 0.19379095725855866 26.560013284412264 -9.6146839810292 0.22054282651005225 1.494138719650643 1.9830118932937975e-17 0.9993147858602911 0.008811522293200091 1.0372517659424465 0.09081257340985309 0.46580735043170685 0.12834346640044061 2.4283764861590736e-10 9.6146839810292 -1.494138719650643 AYHEQLSVAEITNACFEPANQMVK(ub)CDPR ddPTM_RPMI8226_Bortezomib_8h_R1 2 AYHEQLSVAEITNACFEPANQMVKCDPR 28 1 P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2 P68363;P68366-2;Q71U36 TUBA1B;TUBA4A;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain 1 2125509100.0 572364500.0 383736000.0 1169408600.0 True False 868318791.9499251 315255312.6569471 938274477.6400017 1.0 0.3630640216239009 1.080564518859464 29.693649565741183 -6.672490296796114 1.9286335169677362 0.5943200825159576 1.0776931871725508 0.29011190141516663 0.2704020980112368 0.4554090573097168 3.268141576732624 0.11277954719637848 0.3003339474002415 2.1257378388834964e-07 6.672490296796114 0.4833731046565932 AYHEQLSVAEITNACFEPANQMVK(ub)CDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 AYHEQLSVAEITNACFEPANQMVKCDPR 28 1 P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2 P68363;P68366-2;Q71U36 TUBA1B;TUBA4A;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain 1 159724600.0 75466600.0 28027000.0 56231000.0 True False 103368641.42818166 26788674.467104983 42950395.91379708 1.0 0.25915668520919066 0.4155070176058965 26.623223345935155 -10.2241366340336 8.072503041424834 1.0000003615236701 0.3373318514374226 0.9599223015553865 0.06382975591441188 4.1528935296751464e-07 3.992907393915179e-08 0.06180292948403321 0.0206009651374168 5.968474819676548e-11 10.2241366340336 -0.6626685100862475 AYHEQLSVAEITNACFEPANQMVK(ub)CDPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYHEQLSVAEITNACFEPANQMVKCDPR 28 1 P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2 P68363;P68366-2;Q71U36 TUBA1B;TUBA4A;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain 1 149565300.0 64508000.0 3692200.0 81365100.0 True False 53641260.188945845 3672309.385755679 98378166.22028348 1.0 0.06846053528236185 1.8340017716540675 25.676839794947337 -6.763343685727789 1.5998495584400398 0.4611690323940248 1.841550174890149 0.7044930592697244 0.392018790507107 0.2773293266914152 1.3997016240832063 0.19326664089884393 0.46293626922511116 1.72447266346224e-07 6.763343685727789 1.3803811424961243 AYHEQLSVAEITNACFEPANQMVK(ub)CDPR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AYHEQLSVAEITNACFEPANQMVKCDPR 28 1 P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2 P68363;P68366-2;Q71U36 TUBA1B;TUBA4A;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain 1 1702360700.0 572364500.0 291465000.0 838531200.0 True False 740937128.2410321 275244716.5316736 685927125.6566831 1.0 0.3714818788810034 0.9257561802646582 29.464775887833632 -10.454357310192115 8.783853802950496 1.0000056615144748 0.6486190295728412 0.34889605161487236 0.22628153598792905 2.5088593515146106e-05 1.558506507172262e-06 0.2190996814998541 0.07303205170295698 3.512713176556389e-11 10.454357310192115 -0.35138663194163355 AYHEQLTVAEITNACFEPANQMVK(ub)CDPR ddPTM_RPMI8226_Bortezomib_8h_R1 2 AYHEQLTVAEITNACFEPANQMVKCDPR 28 1 Q9BQE3;F5H5D3;A0A1W2PQM2 Q9BQE3 TUBA1C Tubulin alpha-1C chain 1 433149100.0 122778800.0 93327300.0 217043000.0 True False 186264415.93261203 76672314.14547685 174144355.91667375 1.0 0.41163157096638286 0.9349308886764331 27.47277684636307 -10.426956717790128 8.74391637196346 1.0000031880971607 0.6732812298214109 0.3419929313216842 0.21363605185603396 1.3277692332169684e-05 8.700173814486074e-07 0.20685423583695395 0.06895073924899364 3.741478743545853e-11 10.426956717790128 -0.3267219582757498 AYHEQLTVAEITNACFEPANQMVK(ub)CDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYHEQLTVAEITNACFEPANQMVKCDPR 28 1 Q9BQE3;F5H5D3;A0A1W2PQM2 Q9BQE3 TUBA1C Tubulin alpha-1C chain 1 26805200.0 15922000.0 3288800.0 7594400.0 True False 21808793.675871283 3143489.9413927644 5800759.131577607 1.0 0.1441386437100666 0.26598257646847406 24.378406635658788 -10.784794438052762 7.204775646304995 1.0223782553669807 0.20506061008927087 0.9826852788544796 0.049742577252013725 0.01615584375928609 0.00048257197292701673 0.04351777893779375 0.01605434777454042 1.6413664873130935e-11 10.784794438052762 -0.8173176452777098 AYHEQLTVAEITNACFEPANQMVK(ub)CDPR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 AYHEQLTVAEITNACFEPANQMVKCDPR 28 1 Q9BQE3;F5H5D3;A0A1W2PQM2 Q9BQE3 TUBA1C Tubulin alpha-1C chain 1 396009800.0 122778800.0 66020000.0 207211000.0 True False 158939576.93197268 62345928.96375587 169500724.16440445 1.0 0.39226182784191244 1.06644756099327 27.24390316845552 -6.66923796229329 1.9401882812599285 0.6118236805977474 1.0637056061566275 0.27560499350709533 0.2582004459385419 0.4628830391129893 3.3585733458290417 0.10716759612621637 0.2865978866639955 2.141716772055512e-07 6.66923796229329 0.45188192555888007 AYHLLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYHLLVK 7 0 Q99707;Q99707-2;B1ANE3 Q99707 MTR Methionine synthase 0 5840600.0 1731700.0 1391700.0 2717200.0 False True 2270275.469806653 1184063.7848041118 2436050.209222867 1.0 0.521550710718357 1.0730196584603595 21.114435930634226 -6.677271361699321 1.911335425804755 0.6965455280268825 1.0708905882429316 0.31177720299523326 0.20289956406092508 0.44462056483779655 3.1379157605978407 0.08525027104941245 0.22565129315110669 2.1024643393130785e-07 6.677271361699321 0.3743450602160491 AYHLLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYHLLVK 7 0 Q99707;Q99707-2;B1ANE3 Q99707 MTR Methionine synthase 0 5592300.0 1731700.0 1388400.0 2472200.0 False True 2371956.287432877 1327055.8971751751 1888317.2765572215 1.0 0.5594773833759906 0.796101212556877 21.177645992157117 -10.057132414375094 5.119254509249003 1.000004801321878 0.6777892979653214 0.7120067023779003 0.09660127374998338 5.2936671918983715e-06 9.7498771423097e-07 0.09353517457978273 0.031177927037452913 8.767334684164995e-11 10.057132414375094 -0.3222155033565567 AYHLLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYHLLVK 7 0 Q99707;Q99707-2;B1ANE3 Q99707 MTR Methionine synthase 0 3593710.0 1348800.0 1389400.0 855510.0 False True 1121586.9619713866 1381915.026425692 1034393.1855686863 1.0 1.2321068925379919 0.9222585681190143 20.097110053092987 -6.70615734877031 1.8084176735150188 1.1432421037730658 0.9230489607155643 0.4471393082559324 0.09786832230561895 0.38280930077144143 2.4378385122815773 0.043102105708433654 0.11003277591806176 1.9671734360695393e-07 6.70615734877031 -0.22019314305750148 AYHLQK(ub)STCGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYHLQKSTCGK 11 1 P61927;D6RG19;D6R9X9 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 1 94980000.0 18542000.0 24449000.0 51989000.0 True False 24308741.560983453 20801304.50145557 46609676.993702196 1.0 0.8557129314683461 1.9174039460978383 24.534971872645144 -6.872587704540864 1.120259257584756 0.9169608304448766 1.9827335224677576 0.9672010585259571 0.08515213384896887 0.13440079286128584 0.3136624434896119 0.05889095290395137 0.1400942471019266 1.3409491071846558e-07 6.872587704540864 1.065772692022881 AYHLQK(ub)STCGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYHLQKSTCGK 11 1 P61927;D6RG19;D6R9X9 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 1 45427000.0 18596000.0 11229000.0 15602000.0 True False 18005680.15893576 15712798.258461425 11515368.150032876 1.0 0.8726578568410016 0.6395408586838689 24.101948762122955 -6.961737931045065 0.41020924024118255 1.0114573457781912 0.492087260875569 0.999829315665936 0.0019499362304249699 0.07908608031496274 0.01888003796913642 0.003001975124842931 0.019462196411266324 1.0920991496707365e-07 6.961737931045065 -0.5193700849026223 AYHLQK(ub)STCGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYHLQKSTCGK 11 1 P61927;D6RG19;D6R9X9 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 1 74813000.0 10279000.0 19375000.0 45159000.0 True False 15593994.495558824 15917379.872434067 36233303.85610718 1.0 1.020737815251079 2.323542173009388 23.894487194606285 -6.910357911218817 0.8932730385185734 0.9601173167210302 2.4932149571105495 0.9910563670107525 0.05854817608300863 0.1041824943874574 0.13747937878184593 0.04801908252661728 0.13288899510012428 1.2292552981065617e-07 6.910357911218817 1.5330976403895193 up AYHLQK(ub)STCGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYHLQKSTCGK 11 1 P61927;D6RG19;D6R9X9 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 1 109652000.0 18542000.0 21835000.0 69275000.0 True False 25397478.478709072 20870257.501310796 52913671.76340976 1.0 0.8217452578533146 2.0834222502744812 24.598181934168036 -6.871109495121087 1.1281610335629866 0.8984682189365436 2.158902887573496 0.9657804778925002 0.1031320311621776 0.13579801073902784 0.3223458239946267 0.07089510044445067 0.16818423254592205 1.3455210760472482e-07 6.871109495121087 1.2604346686369523 up AYHLQK(ub)STCGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYHLQKSTCGK 11 1 P61927;D6RG19;D6R9X9 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 1 67668800.0 18596000.0 9579800.0 39493000.0 True False 15463397.94248214 9528191.715958582 47750803.70499947 1.0 0.6161771010097373 3.0879890618228925 23.88235403755723 -6.867245857483821 1.1486252028111796 0.7861671966794744 3.225334670687436 0.9618530819276333 0.21213228921624655 0.1395197305706182 0.3457671033203096 0.14356072758136582 0.33833866328629636 1.3575447123948332e-07 6.867245857483821 2.4391674740079616 up AYHNSPAYLAYINAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYHNSPAYLAYINAK 15 0 Q969G3;Q969G3-2;A0A2R8Y855;A0A2U3TZQ7;Q969G3-4;Q969G3-3;Q969G3-5;Q969G3-6;B4DGM3;A0A2R8YES3;A0A2R8Y4T4;A0A2R8Y7I9;A0A2R8Y765;A0A2R8Y7U4;J3QKS7;J3QR61;A0A2R8YD78;J3KT85 Q969G3 SMARCE1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 0 41594000.0 15086000.0 10406000.0 16102000.0 False True 19777892.093031827 8853465.362270294 14435919.501290536 1.0 0.4476445376800068 0.7299018233786713 24.237385337579504 -10.40263221499239 5.0161412776610526 1.0004145722479925 0.5887731805292961 0.7389144286452425 0.11523105435759906 0.0005347721098114973 6.368541949948801e-05 0.11168187808797031 0.0371906628743872 3.957015805833217e-11 10.40263221499239 -0.4116413917186964 AYHNSPAYLAYINAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYHNSPAYLAYINAK 15 0 Q969G3;Q969G3-2;A0A2R8Y855;A0A2U3TZQ7;Q969G3-4;Q969G3-3;Q969G3-5;Q969G3-6;B4DGM3;A0A2R8YES3;A0A2R8Y4T4;A0A2R8Y7I9;A0A2R8Y765;A0A2R8Y7U4;J3QKS7;J3QR61;A0A2R8YD78;J3KT85 Q969G3 SMARCE1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 0 28909700.0 7475800.0 3998900.0 17435000.0 False True 7238484.8210460385 5595681.623988007 12868250.461211579 1.0 0.7730459843914367 1.7777547068686095 22.787256309459934 -6.8473561596100385 1.2477491453982181 0.879107567207302 1.8159233641349917 0.9363725764969336 0.1085222717522735 0.16039044541658648 0.48185127914491316 0.06810059095295984 0.15734863135089933 1.4211628307830295e-07 6.8473561596100385 0.9368157969276897 AYHNSPAYLAYINAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYHNSPAYLAYINAK 15 0 Q969G3;Q969G3-2;A0A2R8Y855;A0A2U3TZQ7;Q969G3-4;Q969G3-3;Q969G3-5;Q969G3-6;B4DGM3;A0A2R8YES3;A0A2R8Y4T4;A0A2R8Y7I9;A0A2R8Y765;A0A2R8Y7U4;J3QKS7;J3QR61;A0A2R8YD78;J3KT85 Q969G3 SMARCE1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 0 25830000.0 15086000.0 0.0 10744000.0 False True 20663701.883820776 0.0 8206488.479625745 1.0 0.0 0.39714512558135795 24.300595399102395 -10.697962388440569 6.683886638037916 1.0076750117763513 0.19857256279068694 0.8444695833893238 0.16213381858464557 0.018462704157580667 0.0008343084513654401 0.1563043145894831 0.052328464936278934 2.0046456298091453e-11 10.697962388440569 -0.8091024489856644 AYHNSPAYLAYINAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYHNSPAYLAYINAK 15 0 Q969G3;Q969G3-2;A0A2R8Y855;A0A2U3TZQ7;Q969G3-4;Q969G3-3;Q969G3-5;Q969G3-6;B4DGM3;A0A2R8YES3;A0A2R8Y4T4;A0A2R8Y7I9;A0A2R8Y765;A0A2R8Y7U4;J3QKS7;J3QR61;A0A2R8YD78;J3KT85 Q969G3 SMARCE1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 0 17991500.0 7475800.0 6180600.0 4335100.0 False True 6216458.934093791 6147303.881046958 5241549.366762299 1.0 0.9888754910504506 0.8431728452375581 22.56766158489421 -6.922172147256038 0.8084709961762184 1.0029702521805692 0.8184630205646841 0.9947628797591087 0.005170790926084165 0.09691081782483192 0.0991206652927434 0.004507167390985276 0.0137942920096427 1.1962662568643982e-07 6.922172147256038 -0.18450723161588511 AYHNSPAYLAYINAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYHNSPAYLAYINAK 15 0 Q969G3;Q969G3-2;A0A2R8Y855;A0A2U3TZQ7;Q969G3-4;Q969G3-3;Q969G3-5;Q969G3-6;B4DGM3;A0A2R8YES3;A0A2R8Y4T4;A0A2R8Y7I9;A0A2R8Y765;A0A2R8Y7U4;J3QKS7;J3QR61;A0A2R8YD78;J3KT85 Q969G3 SMARCE1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 0 34812600.0 6990200.0 15422400.0 12400000.0 False True 9048951.697441854 14564129.882620834 10143327.234744355 1.0 1.6094825532926786 1.1209394827040444 23.109319237928666 -10.5174127072106 5.560711693488639 0.9992431408965022 1.3652110179983596 0.4269704287950057 0.19944687338577782 0.0018751350034250309 0.00016273392359456056 0.1934955486182521 0.06437120158968787 3.037996665103088e-11 10.5174127072106 0.3659678771018574 AYILNLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYILNLVK 8 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 32833500.0 13077000.0 7467500.0 12289000.0 False True 12661877.792987883 10449311.692498054 9070142.237902435 1.0 0.8252576642529955 0.7163346848068188 23.593988040679143 AYILNLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYILNLVK 8 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 28429000.0 13077000.0 9673600.0 5678400.0 False True 10874104.909326669 9621486.396740744 6865727.186044844 1.0 0.8848072073029606 0.6313832028745779 23.37439331611342 -6.958139334617481 0.4609154371891676 1.0073197200223791 0.49863910785754145 0.9996948194007685 0.002689827062681885 0.0803727098819922 0.023639432072369945 0.0034471689786629866 0.020933286104723857 1.1011859595761893e-07 6.958139334617481 -0.5086806121648377 AYILNLVK(ub)QIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYILNLVKQIK 11 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 1 5571700.0 1416000.0 1603400.0 2552300.0 True False 1371049.8550792139 2243645.9816205422 1883776.0626412549 1.0 1.6364437611868703 1.373966129431827 20.38684960168699 -10.097027489277039 4.670135130996906 0.9999736371655286 1.5052049452236413 0.8316377014463538 0.1071560445108055 74567915.24875008 0.8051200742148882 24578.748345179734 0.0366823642101972 7.997836299806756e-11 10.097027489277039 0.5052313080581128 AYILNLVK(ub)QIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYILNLVKQIK 11 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 1 4289720.0 890320.0 1475000.0 1924400.0 True False 1219495.3639933257 1409829.622827271 1469896.354262081 1.0 1.1560762463341245 1.2053316459103207 20.217852842951054 -13.99999999999899 0.16142583527147805 0.22898463019629559 1.2529983706931627 0.9995326860432987 0.0018920765576972793 12.019531811249797 0.1270151506720148 2.9013142578695557 0.04352322804076843 1.0000000000023273e-14 13.99999999999899 1.024013740496867 AYILNLVK(ub)QIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYILNLVKQIK 11 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 1 5920100.0 1416000.0 3169700.0 1334400.0 True False 1177466.7394361545 3152624.1969638113 1613416.8704315042 1.0 2.6774634827251997 1.3702441150941642 20.167254877121266 -6.583354575636808 2.2536165106660957 2.1399672835694212 1.3736322233123877 0.0 0.7281167614001566 0.6892707500413543 6.589070112069483 0.270720696383338 0.8132777704965346 2.6100295502434436e-07 6.583354575636808 -0.7663350602570336 AYIVQLQIEDLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYIVQLQIEDLTR 13 0 Q15637-6;Q15637-2;Q15637-4;Q15637-3;Q15637;Q15637-5;Q15637-7;C9J792 Q15637-6 SF1 Splicing factor 1 0 20362200.0 9883200.0 5046600.0 5432400.0 False True 9569463.22579017 7061733.697671338 4009491.4714933033 1.0 0.737944598463958 0.4189881268039704 23.19000657207004 -6.968496863267514 0.2918627834714346 1.0609495919027554 0.08610298062942183 0.9999681691357277 0.0013403638070711224 0.07679351058681802 0.01076681945023776 0.005517207976963037 0.028862634687167377 1.0752343663453854e-07 6.968496863267514 -0.9748466112733336 down AYIVQLQIEDLTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYIVQLQIEDLTR 13 0 Q15637-6;Q15637-2;Q15637-4;Q15637-3;Q15637;Q15637-5;Q15637-7;C9J792 Q15637-6 SF1 Splicing factor 1 0 194449000.0 55314000.0 78242000.0 60893000.0 False True 83915381.99507153 64279103.79246383 48857471.85964994 1.0 0.7659990607709923 0.5822230763666119 26.322431950371158 -6.973839155981737 0.13857862078756855 1.251222017398852 0.0922120034169975 0.9999989703120294 0.00017339023222476315 0.07507546904061517 0.004191308362919899 0.010543638245733285 0.02408941292452978 1.062088836443716e-07 6.973839155981737 -1.1590100139818544 AYIVQLQIEDLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYIVQLQIEDLTR 13 0 Q15637-6;Q15637-2;Q15637-4;Q15637-3;Q15637;Q15637-5;Q15637-7;C9J792 Q15637-6 SF1 Splicing factor 1 0 4304920.0 1472500.0 741020.0 2091400.0 False True 2016923.0428162566 708279.2861745512 1597454.3937350414 1.0 0.3511682256282676 0.7920254565114663 20.943724607233673 -10.306678945159199 5.637760311810942 1.0000528536200308 0.5715968410700505 0.5573389745157838 0.17997921084671573 0.00011958022837313037 1.4705429364127012e-05 0.17428553833673385 0.05808804052273774 4.9353852048601485e-11 10.306678945159199 -0.42845601254998034 AYIVQLQIEDLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYIVQLQIEDLTR 13 0 Q15637-6;Q15637-2;Q15637-4;Q15637-3;Q15637;Q15637-5;Q15637-7;C9J792 Q15637-6 SF1 Splicing factor 1 0 21474700.0 9883200.0 6156800.0 5434700.0 False True 8218318.69999675 6123632.096370886 6571070.642786334 1.0 0.7451198134203907 0.799563862470913 22.970411847504316 -10.752739438796517 6.928494807812629 1.0044069661033597 0.7723418379456585 0.9588702999633139 0.022226689950806455 0.001534781231977999 5.4772385856635695e-05 0.02182989494040269 0.007173633335065768 1.7670976983194815e-11 10.752739438796517 -0.2320651281577012 AYIVQLQIEDLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYIVQLQIEDLTR 13 0 Q15637-6;Q15637-2;Q15637-4;Q15637-3;Q15637;Q15637-5;Q15637-7;C9J792 Q15637-6 SF1 Splicing factor 1 0 150824000.0 55314000.0 51008000.0 44502000.0 False True 71605063.40194827 48169359.960364394 36403092.62908015 1.0 0.6727088514672521 0.5083871293393711 26.093558272463607 -13.999999999999979 0.08925229507175264 2.681408624150549 0.09181972604455224 0.9998459030830509 0.0025366204560449152 12.170470526258422 0.08661912609749546 3.892656100363024 0.37453260776001596 1.000000000000049e-14 13.999999999999979 -2.5895888981059967 AYIYTYK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYIYTYKR 8 1 Q9H305-3;Q9H305-2;Q9H305 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 1 15951400.0 4894100.0 5625100.0 5432200.0 True False 6416212.494531812 4785857.006468062 4870128.053341851 1.0 0.7459006400655819 0.7590347198588567 22.61329049162367 -10.100397403579269 7.4383754708049885 1.0000000503558677 0.7524676799645335 0.9978929192277325 0.005361965622420473 4.47688564042707e-09 5.512234903548921e-10 0.005191701895349833 0.0017305669632142525 7.936017127132933e-11 10.100397403579269 -0.24753237039133424 AYIYTYK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYIYTYKR 8 1 Q9H305-3;Q9H305-2;Q9H305 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 1 20228100.0 5311800.0 7091200.0 7825100.0 True False 5143179.816532318 9922753.140119473 5775471.562031936 1.0 1.9293031731505128 1.1229379037977965 22.29422916359095 -10.198490085047805 4.313250346184614 0.9998710462032584 1.526120537818394 0.3620838772574799 0.32919724428652775 48251962.23040284 57044989.041210525 68664.43321865312 0.11269296684012413 6.33154816483648e-11 10.198490085047805 0.5262494916151356 AYIYTYK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYIYTYKR 8 1 Q9H305-3;Q9H305-2;Q9H305 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 1 93906900.0 21824000.0 46256000.0 25826900.0 True False 33108603.548115134 38001255.400222406 20722201.894667584 1.0 1.147775844577589 0.6258857116867829 24.980702826360055 -6.83105933764017 1.3231169661125388 1.078905892159596 0.6115302747068214 0.907987856131703 0.06662396573775003 0.17950633257782372 0.6142097461309668 0.03953091369368303 0.09097237653596435 1.4755049213162885e-07 6.83105933764017 -0.46737561745277456 AYIYTYK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYIYTYKR 8 1 Q9H305-3;Q9H305-2;Q9H305 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 1 25412600.0 4894100.0 4678300.0 15840200.0 True False 6703581.028079484 4471597.236930723 12099070.999159314 1.0 0.6670460487014948 1.8048668239377708 22.67650055314656 -6.8283679139726665 1.3351478489451158 0.821879736339416 1.8344852550382398 0.9025797492657389 0.14908368007208184 0.1828325162961551 0.6379831966848538 0.08768534840931992 0.20181048468506074 1.484677360163742e-07 6.8283679139726665 1.0126055186988236 AYIYTYK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYIYTYKR 8 1 Q9H305-3;Q9H305-2;Q9H305 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 1 40484100.0 5311800.0 29904000.0 5268300.0 True False 4416997.052639097 29742901.21652075 6369877.1721330015 1.0 6.7337380718308975 1.4421284633475326 22.074634439025225 -6.627128939245708 2.0902664585720268 4.785390461692505 1.462984630260229 0.10727639549801105 2.46127201151629 0.5666854727633016 4.714245970036542 0.9641669781275242 2.7280261467951967 2.3597775263582787e-07 6.627128939245708 -3.322405831432276 AYIYTYK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYIYTYKR 8 1 Q9H305-3;Q9H305-2;Q9H305 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 1 100308000.0 21824000.0 52477000.0 26007000.0 True False 28251598.215354495 49556608.819009595 21273992.854354564 1.0 1.7541170039745226 0.7530190926611839 24.751829148452504 -6.705185134381641 1.8124622963663508 1.4658787059099074 0.7556975778059293 0.44218554830506307 0.3180306234046323 0.3848277790483025 2.4611626118237107 0.13980203112604064 0.35723947259129524 1.9715820958176387e-07 6.705185134381641 -0.7101811281039782 AYLDQTVVPILLQGLAVLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYLDQTVVPILLQGLAVLAK 20 0 Q9C005 Q9C005 DPY30 Protein dpy-30 homolog 0 2569200000.0 1186000000.0 742630000.0 640570000.0 False True 1799248708.2141027 610101874.3053263 513961058.7281958 1.0 0.33908701533036023 0.2856531486624453 30.744747476543974 -13.999999999999998 0.35646665626382423 9.459590711176418 0.2788905713009337 0.9997668338512906 0.004960919309284105 21.320772662260133 0.19267712707225612 136.99051722238113 0.01559948498021879 1.0000000000000041e-14 13.999999999999998 -9.180700139875484 AYLDQTVVPILLQGLAVLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYLDQTVVPILLQGLAVLAK 20 0 Q9C005 Q9C005 DPY30 Protein dpy-30 homolog 0 1580638000.0 1186000000.0 85058000.0 309580000.0 False True 1535300379.555098 80324447.52800888 253239616.55904555 1.0 0.0523183922818318 0.16494467136940966 30.515873798636424 -10.241840834583897 5.8858452901855145 1.000030736153695 0.10863153182561432 0.9881680313990036 0.04597948589883281 1.854553081268998e-05 2.388875826910083e-06 0.04452097303134451 0.014839815262776461 5.730059945724366e-11 10.241840834583897 -0.8913992043280807 AYLEGLCVEWLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYLEGLCVEWLR 12 0 A0A1W2PNZ7;Q53YP1;A0A140T9M0;A0A140T9W2;A0A140T9U0;A0A140T9T1;D9J307;A0A140T953;A0A140TA13;A0A140T9G0 A0A1W2PNZ7;Q53YP1;D9J307 HLA-C;HLA-B 0 1841580.0 700150.0 380710.0 760720.0 False True 917903.4302622443 323909.551995957 682007.9917415063 1.0 0.3528797707002972 0.7430062567111848 19.80798285464425 -10.783169961391257 7.006987829729739 1.0136731237285956 0.5479430137059382 0.6416094674017709 0.15926847097861904 0.03342227331301955 0.0010342450747629081 0.1515027997551688 0.05140367797300923 1.6475175084368116e-11 10.783169961391257 -0.4657301100226574 AYLEGLCVEWLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYLEGLCVEWLR 12 0 A0A1W2PNZ7;Q53YP1;A0A140T9M0;A0A140T9W2;A0A140T9U0;A0A140T9T1;D9J307;A0A140T953;A0A140TA13;A0A140T9G0 A0A1W2PNZ7;Q53YP1;D9J307 HLA-C;HLA-B 0 2567800.0 700150.0 549550.0 1318100.0 False True 959014.3758423106 525269.0638811701 1006791.9271216221 1.0 0.54771761207419 1.0498194317862526 19.871192916167143 -6.6693949243082455 1.9397615921792515 0.7111580563498565 1.047774594030156 0.2763037057038933 0.1921467598816197 0.46248343829426314 3.354388020822386 0.0797675420363255 0.21326822581431412 2.1409428560776524e-07 6.6693949243082455 0.3366165376802994 AYLEGTCVEWLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYLEGTCVEWLR 12 0 O19617;P10321;A0A140T9U8;A0A140T9H5;A2AEA2;A0A140T921;A0A1W2PRU9;P10321-2;A0A140TA05;A0A140T9L3;A0A140T9E1;A0A140T942;O78179;A0A140T912;A0A1W2PRZ0;A0A140T930;A0A140T937;A0A140T9M5;A0A140T9S7;A0A140T9Q4;A0A140TA19;Q5QT33;A0A140T9J9;A0A1W2PRX1;A0A1W2PR11;A0A140T962;A0A140T9B3;A0A1W2PP77;A0A1W2PS56;Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913;A0A140T955;A0A140T933;A0A1W2PPQ2;A0A1W2PRT9;A0A140T975;A0A140T941;A0A1W2PQS8;Q9GJ45;A0A1W2PS39;A0A140T9Z6;Q5RJ27;B0UXQ0 O19617;O78179;Q5QT33;Q53Z42 HLA-C;HLA-A HLA class I histocompatibility antigen, Cw-7 alpha chain 0 4986380.0 935480.0 1517500.0 2533400.0 False True 1226423.3392012068 1291094.9151686695 2271268.0700887735 1.0 1.0527318535943588 1.8519445916351316 20.22602562661081 -6.920299092608006 0.8225060874407378 0.982555497105342 1.9817154741705478 0.9942636155207483 0.029521249189395162 0.09799601069082141 0.10470478860341148 0.025475963552244185 0.0765321053078839 1.2014367367605945e-07 6.920299092608006 0.9991599770652059 AYLGDTSEAK(ub)EFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYLGDTSEAKEFAK 14 1 I1E4Y6;Q6Y7W6-4;Q6Y7W6-5;Q6Y7W6;Q6Y7W6-3 I1E4Y6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 5825200.0 2915900.0 1844500.0 1064800.0 True False 2823336.3505829605 2581018.4689404313 785896.9366847194 1.0 0.9141732151068378 0.2783575313378613 21.428969579943992 -6.931555260244927 0.7339122767208701 1.009132518032715 0.14250250448676377 0.9968352045347532 0.018107215564986307 0.09183825309374785 0.07378230630801899 0.016651860987378867 0.05704628601939631 1.1706976316182262e-07 6.931555260244927 -0.8666300135459513 down AYLGDTSEAK(ub)EFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYLGDTSEAKEFAK 14 1 I1E4Y6;Q6Y7W6-4;Q6Y7W6-5;Q6Y7W6;Q6Y7W6-3 I1E4Y6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 20827600.0 5304000.0 8297200.0 7226400.0 True False 8046555.774340295 6816499.833680504 5798098.87255637 1.0 0.8471326148533856 0.7205690279368917 22.93993995744847 -6.973292203259863 0.16118647578711034 1.1260290631399947 0.43831085895720473 0.9999979965015093 0.00016160578135836624 0.075248156358748 0.004981657336311677 0.005792018479815018 0.015121783877496858 1.063427279274169e-07 6.973292203259863 -0.6877182041827901 AYLGDTSEAK(ub)EFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYLGDTSEAKEFAK 14 1 I1E4Y6;Q6Y7W6-4;Q6Y7W6-5;Q6Y7W6;Q6Y7W6-3 I1E4Y6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 6813200.0 2915900.0 2515600.0 1381700.0 True False 2424700.046272512 2502047.9634924983 1670607.0817410115 1.0 1.0318999941204658 0.6889953601927931 21.209374855378268 -6.884135735103441 1.0564898358583947 1.0210972116849137 0.662683850978228 0.9768701726200809 0.023524057946915356 0.12402858756825845 0.25069632776337486 0.01708359864152687 0.041781759782083844 1.305762719147141e-07 6.884135735103441 -0.3584133607066857 AYLGDTSEAK(ub)EFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYLGDTSEAKEFAK 14 1 I1E4Y6;Q6Y7W6-4;Q6Y7W6-5;Q6Y7W6;Q6Y7W6-3 I1E4Y6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 12260500.0 5304000.0 6956500.0 0.0 True False 6866132.557470683 6569364.6597450385 0.0 1.0 0.9567780121863877 0.0 22.71106627954092 -7.059407582012781 1.0389245645212482 1.0097891918455766 5.084866724475959e-20 0.98830779954127 0.04990809962054257 0.08476390613757495 0.17571061013979364 0.04011049125836243 0.0716170372761007 8.721524758320092e-08 7.059407582012781 -1.0097891918455766 down AYLK(ub)MAEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYLKMAEEK 9 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 2797400.0 909790.0 904590.0 983020.0 True False 1192743.5004188924 769628.6980642034 881306.5201936796 1.0 0.645259184220169 0.7388902307027153 20.18585239403333 -9.99074473483091 6.829004879741623 1.000000039467192 0.6920747074614424 0.9351525692492723 0.03822471466084523 2.299149740182528e-08 3.351512063346734e-09 0.03701092551152885 0.01233697360791486 1.0215397374646009e-10 9.99074473483091 -0.30792533200574956 AYLK(ub)MAEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYLKMAEEK 9 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 18769100.0 2427000.0 4730100.0 11612000.0 True False 3681936.4374668063 3885976.6985600223 9316883.110279594 1.0 1.0554165626046486 2.530430187624223 21.81203329048702 -6.914841180462551 0.8621077702004001 0.9610216411824533 2.7421967319290257 0.9926240089240952 0.060870086459645645 0.1013032236348922 0.12204331947376437 0.051060245670447583 0.14615897402329045 1.216630835725382e-07 6.914841180462551 1.7811750907465724 up AYLK(ub)MAEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYLKMAEEK 9 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 18173700.0 2427000.0 3815700.0 11931000.0 True False 3141799.343322282 3603352.940730125 9759680.422397994 1.0 1.1469074078167498 3.1063983901905274 21.58315961257947 -6.92192508582062 0.810319570687884 0.9596913826159642 3.436814175742707 0.9946991981763058 0.06990993249353418 0.09705232539467148 0.09984119362622419 0.06085686362002884 0.18579002693452 1.196946982393786e-07 6.92192508582062 2.477122793126743 up AYLLGK(ub)EDAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYLLGKEDAAR 11 1 Q13501;E7EMC7;E3W990;D6RBF1;C9J6J8 Q13501 SQSTM1 Sequestosome-1 1 11479480.0 3441180.0 5247600.0 2790700.0 True False 4511420.304434524 4464678.5349845905 2501945.1342846556 1.0 0.9896392341445136 0.5545803683654471 22.105150269674574 -6.912026320810703 0.8818269163937098 1.0126223901240419 0.4958504007481106 0.9916639496680661 0.018951903235666662 0.10309314622248317 0.13161339523295698 0.015673338998916115 0.04389746404713519 1.2245419825393566e-07 6.912026320810703 -0.5167719893759313 AYLLGK(ub)EDAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYLLGKEDAAR 11 1 Q13501;E7EMC7;E3W990;D6RBF1;C9J6J8 Q13501 SQSTM1 Sequestosome-1 1 19439800.0 6126900.0 6288500.0 7024400.0 True False 5932404.913195501 8799530.84409428 5184498.912517042 1.0 1.4832990958728063 0.8739286998069055 22.500185640873074 -6.69534848829242 1.8472992983279313 1.3014664780307774 0.8758832406042568 0.3955823548865456 0.20418538794908775 0.40529322223630265 2.6854564946810466 0.08828804583879243 0.22837977368496704 2.0167474278004289e-07 6.69534848829242 -0.4255832374265206 AYLLGK(ub)EDAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYLLGKEDAAR 11 1 Q13501;E7EMC7;E3W990;D6RBF1;C9J6J8 Q13501 SQSTM1 Sequestosome-1 1 55128600.0 3564500.0 19255800.0 32308300.0 True False 5407607.099855959 15819452.043747926 25922550.34376905 1.0 2.9254070703785606 4.7937192671522935 22.366558902955898 -6.971493521691411 0.2196048835833249 0.13410698743504654 7.637751027576081 0.9999918054379378 0.004433722063447771 0.07582103644702887 0.0072709661183819755 0.05190770231558122 0.18952178244462917 1.0678407212474037e-07 6.971493521691411 7.503644040141034 AYLLGK(ub)EDAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYLLGKEDAAR 11 1 Q13501;E7EMC7;E3W990;D6RBF1;C9J6J8 Q13501 SQSTM1 Sequestosome-1 1 9788680.0 3441180.0 2818100.0 3529400.0 True False 4713477.240392837 2693587.02378951 2695828.41027468 1.0 0.5714649475139967 0.5719404746823389 22.168360331197466 -10.019828157874032 5.017188443369621 1.0000051765270326 0.571702711094465 0.9999990746524388 0.00019413316639228456 53748.913348137 107341.96915335715 1.9602433958277226 6.645694386492256e-05 9.553705333235482e-11 10.019828157874032 -0.42830246543256756 AYLLGK(ub)EDAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYLLGKEDAAR 11 1 Q13501;E7EMC7;E3W990;D6RBF1;C9J6J8 Q13501 SQSTM1 Sequestosome-1 1 21766300.0 6126900.0 10682600.0 4956800.0 True False 5094788.8176916465 10625050.71346992 5993243.96234628 1.0 2.0854742156484383 1.176347867753566 22.28059091630735 -10.246045011229215 4.407005741454476 0.9996998886797827 1.6309110417106083 0.39103675732034093 0.37114927737630293 262087715.11068442 415.81458058299614 798160.6641804652 0.1270542696331926 5.6748578689341805e-11 10.246045011229215 0.6312111530308256 AYLLGK(ub)EDAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYLLGKEDAAR 11 1 Q13501;E7EMC7;E3W990;D6RBF1;C9J6J8 Q13501 SQSTM1 Sequestosome-1 1 14330100.0 3564500.0 7200900.0 3564700.0 True False 4614315.516799448 6800163.584900177 2915961.1769107427 1.0 1.4737101440381917 0.6319379691948965 22.137685225048347 -6.754006103775304 1.6349640068962557 1.2771967085125815 0.6297337147988052 0.6660599065979289 0.19910877667988797 0.29310302465601956 1.542664194451231 0.09615397450342458 0.23246759796971647 1.761951282960212e-07 6.754006103775304 -0.6474629937137762 AYLPVNESFGFTADLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYLPVNESFGFTADLR 16 0 P13639 P13639 EEF2 Elongation factor 2 0 28392100.0 12484000.0 4345100.0 11563000.0 False True 12087702.253396101 6080121.089397156 8534303.417435579 1.0 0.5030005671829744 0.706031902385569 23.5270366935232 -10.212988276397299 5.471028932848067 1.0000195598153179 0.6045162347842362 0.8349579242249238 0.08288719550718089 1.977623042277995e-05 2.8449714937594643e-06 0.0802591462858277 0.026751727317744212 6.123669220973728e-11 10.212988276397299 -0.39550332503108165 AYLPVNESFGFTADLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYLPVNESFGFTADLR 16 0 P13639 P13639 EEF2 Elongation factor 2 0 548665700.0 129410000.0 277805700.0 141450000.0 False True 196324431.138269 228229102.3291588 113492345.50026257 1.0 1.1625099382991193 0.5780856964273144 27.548664475911323 -6.832523308137108 1.3166992860198845 1.0866920366819341 0.5615442678759577 0.9108101136497925 0.07355667243212173 0.17771770834361922 0.6016986437957004 0.04385187747216643 0.10090954314870823 1.4705394909482554e-07 6.832523308137108 -0.5251477688059765 AYLPVNESFGFTADLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYLPVNESFGFTADLR 16 0 P13639 P13639 EEF2 Elongation factor 2 0 27171600.0 12484000.0 6484900.0 8202700.0 False True 10380999.13497241 6449964.556548127 9917846.64500037 1.0 0.6213240626154112 0.9553845941079282 23.307441968957477 -10.233017396666632 7.759288078168552 1.0000002367938512 0.7883543283616697 0.3486144072558639 0.13637964089326954 5.586932566187119e-07 5.528290826584931e-08 0.13204916705937664 0.04401633982844843 5.847666594987372e-11 10.233017396666632 -0.21164590843218145 AYLPVNESFGFTADLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYLPVNESFGFTADLR 16 0 P13639 P13639 EEF2 Elongation factor 2 0 308096500.0 129410000.0 95215000.0 83471500.0 False True 167523796.05246648 89916201.54928832 68280543.48991644 1.0 0.5367368915227281 0.4075871314934374 27.319790798003773 -13.999999999992934 0.1791994398558859 3.397807170072075 0.30414439236465707 0.9994991250889171 0.005692410157039164 12.19446232312416 0.1341875484538492 10.179053133465214 0.09708777815037775 1.0000000000162709e-14 13.999999999992934 -3.0936627777074177 AYPHVFTK(ub)GIPNVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYPHVFTKGIPNVLR 15 1 O14949 O14949 UQCRQ Cytochrome b-c1 complex subunit 8 1 11072900.0 1944300.0 1304900.0 7823700.0 True False 2548996.1286279853 1110214.0064603626 7014178.574229704 1.0 0.43554950672206116 2.751741556392686 21.281497751545235 -6.842288673440907 1.2716859185380467 0.6997567831538765 2.831459528722255 0.9283263087925003 0.26400430350907433 0.16614006125148872 0.5209137734352797 0.16272077594629158 0.37514702920522375 1.437842533576444e-07 6.842288673440907 2.1317027455683784 up AYPHVFTK(ub)GIPNVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYPHVFTKGIPNVLR 15 1 O14949 O14949 UQCRQ Cytochrome b-c1 complex subunit 8 1 13789700.0 2842700.0 4449100.0 6497900.0 True False 2752460.044515312 6225648.831749998 4795905.057178476 1.0 2.261848939153734 1.7424067850630687 21.39229019069856 -10.498375997849088 5.602261024180466 0.9984487138016364 2.002127862108237 0.8322883643265677 0.21206137140238487 0.004113559317032933 0.0003683260128075286 0.2055624370219719 0.06844251331794457 3.1741248280553797e-11 10.498375997849088 1.0036791483066008 AYPHVFTK(ub)GIPNVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYPHVFTKGIPNVLR 15 1 O14949 O14949 UQCRQ Cytochrome b-c1 complex subunit 8 1 12718870.0 1944300.0 2424570.0 8350000.0 True False 2663160.2527318527 2317444.4804191943 6377901.973648078 1.0 0.8701858921339692 2.394862257014262 21.344707813068126 -6.886197797785706 1.0445875003248202 0.9104559195222031 2.5166431928704487 0.9783519490892163 0.10154802785546373 0.12228340131064236 0.24028977046976 0.07441497897068654 0.1831560002357389 1.299577555524426e-07 6.886197797785706 1.6061872733482456 up AYPLADAHLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYPLADAHLTK 11 0 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 0 4860760.0 2812400.0 317560.0 1730800.0 False True 2723121.9014299256 444363.3640535224 1277451.557112991 1.0 0.16318159088661616 0.4691128797584106 21.37683013586013 -10.458683675820797 6.063350010405666 1.0003570855425834 0.3161472353977547 0.8694887863297205 0.12489592568131666 0.0006031853972186932 5.3850396272084206e-05 0.12099007595739661 0.04030998668107484 3.477893862510198e-11 10.458683675820797 -0.6842098501448287 AYSEAHEISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYSEAHEISK 10 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 23306900.0 8278100.0 2956300.0 12072500.0 False True 8015316.246702855 4136766.0069008362 8910350.082763221 1.0 0.5161076468570429 1.1116654425742145 22.934328012791845 -6.690633546584359 1.864327587231215 0.6968033260736696 1.109612240128963 0.37328348488072083 0.2046272900629113 0.41532813453660383 2.799350189263187 0.08779302439682318 0.22842299832280058 2.038761639163609e-07 6.690633546584359 0.4128089140552934 AYSFAMGCWPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYSFAMGCWPK 11 0 H0Y4B0;O43414-3;O43414-2;O43414;F6QUN3;A0A3B3ISV9 H0Y4B0 ERI3 ERI1 exoribonuclease 3 0 13230900.0 5439300.0 6333600.0 1458000.0 False True 7130974.974256125 5388651.568179439 1307140.1461235634 1.0 0.7556682764465263 0.18330454823394174 22.76566791027983 -7.123746011549994 0.5386757012673864 1.006814854874836 2.09355815515529e-12 0.9991652939457071 0.009888386493521773 0.07872201259827964 0.03659607746308873 0.010713780392266248 0.04502991504475253 7.520625942118301e-08 7.123746011549994 -1.0068148548727422 down AYSFAMGCWPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYSFAMGCWPK 11 0 H0Y4B0;O43414-3;O43414-2;O43414;F6QUN3;A0A3B3ISV9 H0Y4B0 ERI3 ERI1 exoribonuclease 3 0 17720100.0 5439300.0 4156100.0 8124700.0 False True 7450356.201555496 3972469.7596152 6205813.193448934 1.0 0.5331919242714627 0.8329552340267 22.828877971802722 -10.099152812716442 5.166764160055075 1.0000070225280908 0.6830735791485529 0.5984557745900934 0.12237785875321039 9.899838420663226e-06 1.726181969660835e-06 0.11849447695949147 0.03949728407437696 7.958792596582678e-11 10.099152812716442 -0.3169334433795379 AYSNWPTYPQLYVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYSNWPTYPQLYVK 14 0 O76003 O76003 GLRX3 Glutaredoxin-3 0 16984400.0 3522400.0 4801400.0 8660600.0 False True 4617900.51097012 4085049.835710615 7764484.190341379 1.0 0.884611919638874 1.6813883651014885 22.13880566104249 -6.870134324825313 1.133325009744522 0.93468120183911 1.7281828322437982 0.9648201354598607 0.06594281522600186 0.13672925723093057 0.32814187313915777 0.04515102815813936 0.10692672620025188 1.3485457205229392e-07 6.870134324825313 0.7935016304046882 AYSNWPTYPQLYVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYSNWPTYPQLYVK 14 0 O76003 O76003 GLRX3 Glutaredoxin-3 0 11606500.0 4704800.0 0.0 6901700.0 False True 4555448.6992773125 0.0 5093937.723438143 1.0 0.0 1.1182076804522587 22.11916173187856 -10.682987984673977 4.331176774889717 1.0186767395260525 0.5591038402342421 0.17169469278669058 0.4565063739286458 0.08293234016542612 0.006070064840475563 0.4452467618115955 0.14733679863853585 2.0749709234508304e-11 10.682987984673977 -0.45957289929181044 AYSNWPTYPQLYVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYSNWPTYPQLYVK 14 0 O76003 O76003 GLRX3 Glutaredoxin-3 0 13006100.0 3522400.0 3971900.0 5511800.0 False True 4824726.4692808045 3796408.3246831377 4210026.359084251 1.0 0.786864985788313 0.8725937907339681 22.20201572256538 -10.347179143429916 6.726567455147787 1.0000069166487853 0.8297293882779793 0.8402490491882688 0.03499863806257368 3.6304578868669375e-06 3.5232967243532396e-07 0.03388866151418984 0.011295761863024074 4.4959436211541286e-11 10.347179143429916 -0.170277528370806 AYSNWPTYPQLYVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYSNWPTYPQLYVK 14 0 O76003 O76003 GLRX3 Glutaredoxin-3 0 10822500.0 4704800.0 2417400.0 3700300.0 False True 3912249.657979669 2404376.986383668 4474015.621745867 1.0 0.6145765727091446 1.1435915426870533 21.899567007312836 -6.7113486058596115 1.7904545279168 0.7633786277076111 1.14239654240629 0.47150423837027267 0.16238111836765132 0.37235842174795936 2.3277118677093758 0.07215095842010075 0.1829943029139708 1.943799178030083e-07 6.7113486058596115 0.37901791469867896 AYTIDPSNPMVLNHLANHFFFK ddPTM_RPMI8226_Bortezomib_2h_R1 2 AYTIDPSNPMVLNHLANHFFFK 22 0 Q6PD62 Q6PD62 CTR9 RNA polymerase-associated protein CTR9 homolog 0 64777900.0 27301600.0 13530600.0 23945700.0 False True 26434925.652140267 18933439.14114684 17673602.814398285 1.0 0.716228197131847 0.6685701729207385 24.655941933376415 -13.999999999999998 0.25102986275492456 2.983789300652055 0.6495944830364688 0.9995446324549231 0.0031220235016112 14.038965446822703 0.15854037347856678 14.052280334193599 0.021868553042593622 1.0000000000000041e-14 13.999999999999998 -2.334194817615586 AYTIDPSNPMVLNHLANHFFFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYTIDPSNPMVLNHLANHFFFK 22 0 Q6PD62 Q6PD62 CTR9 RNA polymerase-associated protein CTR9 homolog 0 22967000.0 6623500.0 7014200.0 9329300.0 False True 10048333.742711732 5762461.207805263 7485359.765822551 1.0 0.5734743048303802 0.7449354248660222 23.26045295164279 -10.151279404271055 5.2324248459316 1.0000123488539499 0.6592048648479805 0.8404435532881728 0.06999870913634097 1.0084138213450435e-05 1.635541077670641e-06 0.0677784133840113 0.02259198622831107 7.058632895162458e-11 10.151279404271055 -0.3408074840059694 AYTIDPSNPMVLNHLANHFFFK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 AYTIDPSNPMVLNHLANHFFFK 22 0 Q6PD62 Q6PD62 CTR9 RNA polymerase-associated protein CTR9 homolog 0 70341500.0 27301600.0 15626800.0 27413100.0 False True 22702490.06595345 15542615.326723052 33145052.46614647 1.0 0.6846216111787692 1.4599743186697198 24.43634720881069 -6.79627477425208 1.4710275628587735 0.8251585735801883 1.4697235132465145 0.8210483816779949 0.1346772948916951 0.22612580759314269 0.9663682721402845 0.07203725782411924 0.16792997000001977 1.5985463225736367e-07 6.79627477425208 0.6445649396663262 AYTNFDAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYTNFDAER 9 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 9541310.0 2539700.0 926510.0 6075100.0 False True 2459078.613661496 1296470.274685823 4483849.060906587 1.0 0.5272179049027703 1.8233858145064616 21.229686426147836 -6.807990921421871 1.422849061054536 0.7417159130878925 1.8450576773908987 0.8545393073544956 0.2042635436865695 0.20955680035247357 0.8365075638631067 0.11289078383527434 0.2613989680399517 1.5559981581597252e-07 6.807990921421871 1.1033417643030061 AYVDDTPAEQMK(ub)AER ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYVDDTPAEQMKAER 15 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 4580200.0 1143500.0 965700.0 2471000.0 True False 1107200.2184202548 1351309.0460589703 1823770.9715889762 1.0 1.2204739699085394 1.6471916652898781 20.078484702015665 -6.960681886691832 0.4257227657191165 0.9822607699623593 1.901653587059951 0.9997946394827054 0.0038498543613769962 0.07945854113005417 0.020238624113157393 0.005543099822897449 0.035467355789901664 1.0947579642133382e-07 6.960681886691832 0.9193928170975916 AYVDDTPAEQMK(ub)AER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYVDDTPAEQMKAER 15 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 5764900.0 1143500.0 2739500.0 1881900.0 True False 950870.9156392956 2724741.769751826 2275396.589077519 1.0 2.8655222543218812 2.3929605498005055 19.85888997744994 -10.158119768897624 5.235377610847911 0.9999362611715309 2.629241402062142 0.9406481008773644 0.1929225080128854 0.00014354024982040788 2.308203748433123e-05 0.18680360895634912 0.06226547171972412 6.948326715452425e-11 10.158119768897624 1.6293051408906112 AYVDDTPAEQMK(ub)AER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYVDDTPAEQMKAER 15 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 42118400.0 5287000.0 5045400.0 31786000.0 True False 6844125.722350595 4764619.054736956 26001274.15190199 1.0 0.6961618251951927 3.7990643665400015 22.706434830809275 -6.882845370650571 1.0638474709149257 0.8035759124679729 4.031284923201721 0.9759072241422404 0.2167821956347953 0.12513751294660183 0.257332422100479 0.1565515889316646 0.3814580467290461 1.3096481365952224e-07 6.882845370650571 3.227709010733748 up AYVK(ub)EHYPNGVCTVYGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYVKEHYPNGVCTVYGK 17 1 P47755;F8W9N7;A0A0D9SET8 P47755 CAPZA2 F-actin-capping protein subunit alpha-2 1 14999900.0 1650100.0 3846000.0 9503800.0 True False 2503322.338468878 3159651.2510648468 7625369.764336478 1.0 1.262183140584845 3.0460998358686915 21.255412639882675 -6.933236385675124 0.7197381413951411 0.9758590114938149 3.4444502327732067 0.9971368511932385 0.048642713300789175 0.09099193878406588 0.0697024987660549 0.045201915017880206 0.15863931145291738 1.1661746975747233e-07 6.933236385675124 2.4685912212793917 up AYVPALQMAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYVPALQMAFK 11 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 8511300.0 2360600.0 2954300.0 3196400.0 False True 3094769.4600829217 2513529.955771204 2865667.190033853 1.0 0.8121864934339427 0.9259711351672283 21.561400511499418 -10.27332091902203 5.081291215870818 1.0000265791461629 0.8690788143159053 0.638361111689649 0.04645238546880714 1.3989874643037332e-05 2.0007221307111555e-06 0.04498645542787527 0.01499244294266992 5.329409367844885e-11 10.27332091902203 -0.1309477648302576 AYVPALQMAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYVPALQMAFK 11 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 7544100.0 2360600.0 2129000.0 3054500.0 False True 3233377.6128163426 2034933.74033848 2333090.0094021657 1.0 0.6293523318379162 0.7215643481152185 21.62461057302231 -9.851959079915003 6.273233294600869 1.000000020386465 0.6754583399764801 0.9429093055895152 0.03764539800575405 1.0750525818273911e-08 1.991379781636462e-09 0.03645000205685403 0.012149999961422632 1.4061800109498888e-10 9.851959079915003 -0.3245416804099849 AYVSLFMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYVSLFMR 8 0 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y7I0;A0A2R8Y7M9;A0A2R8Y5M9;A0A2R8YE38;K7EMY3;Q8TDI0;Q12873-3;Q12873;Q12873-2 A0A2R8YFD8 CHD4;CHD5;CHD3 Chromodomain-helicase-DNA-binding protein 4;Chromodomain-helicase-DNA-binding protein 5;Chromodomain-helicase-DNA-binding protein 3 0 65057000.0 11687000.0 17362000.0 36008000.0 False True 17730033.434146885 14263615.450074857 28891003.01713297 1.0 0.804488920060583 1.6294951233137998 24.079691920991422 -6.844198381845036 1.2627010667669782 0.8959774603973478 1.6589743436501 0.931441817731776 0.09216583437372637 0.16395210160551268 0.5059543573838393 0.05719005114939193 0.13194564850112842 1.4315338380136066e-07 6.844198381845036 0.7629968832527523 AYVSLFMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYVSLFMR 8 0 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y7I0;A0A2R8Y7M9;A0A2R8Y5M9;A0A2R8YE38;K7EMY3;Q8TDI0;Q12873-3;Q12873;Q12873-2 A0A2R8YFD8 CHD4;CHD5;CHD3 Chromodomain-helicase-DNA-binding protein 4;Chromodomain-helicase-DNA-binding protein 5;Chromodomain-helicase-DNA-binding protein 3 0 50973000.0 11687000.0 17120000.0 22166000.0 False True 15129051.885211146 16167256.950310515 18132015.442366403 1.0 1.068623273485778 1.1984898710070984 23.85081824308387 -6.961111367217293 0.4194785515762037 0.9942273390239114 1.2777805014550276 0.9998092142935663 0.0011368779225378453 0.0793064982385585 0.01968203604819441 0.001679386161293438 0.010811966473033521 1.093675876277252e-07 6.961111367217293 0.2835531624311163 AYVSTLMGVPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYVSTLMGVPGR 12 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 15664600.0 5836900.0 2979900.0 6847800.0 False True 5651610.804457531 4169789.609973213 5054155.750403482 1.0 0.7378055131971264 0.8942858815432185 22.43023068789553 -10.267593294279758 5.321540373395814 1.000023290414654 0.8160456975928895 0.6482135061319245 0.06388284286851206 1.765455374607775e-05 2.4297714670451663e-06 0.06186212313524868 0.020618098878168407 5.4001609711616074e-11 10.267593294279758 -0.1839775928217645 AYVVLGQFLVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYVVLGQFLVLK 12 0 O75531 O75531 BANF1 Barrier-to-autointegration factor;Barrier-to-autointegration factor, N-terminally processed 0 51739200.0 26350000.0 20418000.0 4971200.0 False True 34545105.17376302 17371713.988740645 4456827.911117596 1.0 0.502870490663159 0.1290147443089145 25.0419779684049 -8.097595272135736 0.37313027036321555 1.080946150272712 6.365674781153944e-22 0.9978954638657763 0.016366600218423556 0.09439249942151345 0.08523538695287035 0.05729911493830802 0.08491321934668805 7.987387013809166e-09 8.097595272135736 -1.080946150272712 down AYVVLGQFLVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYVVLGQFLVLK 12 0 O75531 O75531 BANF1 Barrier-to-autointegration factor;Barrier-to-autointegration factor, N-terminally processed 0 286858000.0 138290000.0 88362000.0 60206000.0 False True 133900059.64611882 123645407.40174259 44436242.45871544 1.0 0.923415626016314 0.33186125963016666 26.996581362413405 -6.930755501535831 0.7405705584893031 1.0087485059320578 0.2080507916583934 0.996684523509313 0.017190797862856363 0.09224764413880016 0.0757739838515217 0.015732542955364304 0.0533049375045581 1.1728554721543208e-07 6.930755501535831 -0.8006977142736644 down AYVVLGQFLVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYVVLGQFLVLK 12 0 O75531 O75531 BANF1 Barrier-to-autointegration factor;Barrier-to-autointegration factor, N-terminally processed 0 1521680000.0 306630000.0 533870000.0 681180000.0 False True 465180127.6557252 438596727.3546513 546544474.4282 1.0 0.9428535341029272 1.1749093349763464 28.793214225761904 -6.841557832042992 1.2750400210591852 0.9696013430639008 1.1827847664268316 0.9271086580179579 0.02665253443498599 0.16699301138998204 0.526671784134516 0.016385909281971617 0.0377693310961694 1.4402642072852947e-07 6.841557832042992 0.21318342336293084 AYVVLGQFLVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYVVLGQFLVLK 12 0 O75531 O75531 BANF1 Barrier-to-autointegration factor;Barrier-to-autointegration factor, N-terminally processed 0 101983000.0 26350000.0 22993000.0 52640000.0 False True 36092307.08197519 21977093.232316863 40207516.15483059 1.0 0.6089135056509705 1.1140190086355153 25.105188029927792 -6.699986790041869 1.8309562147745941 0.7571491609809274 1.1125148757961856 0.4175218826626499 0.16508254016866336 0.39553648394957514 2.5779305449183663 0.07193038458951166 0.18498626087346332 1.995323005890821e-07 6.699986790041869 0.35536571481525814 AYVVLGQFLVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYVVLGQFLVLK 12 0 O75531 O75531 BANF1 Barrier-to-autointegration factor;Barrier-to-autointegration factor, N-terminally processed 0 245162000.0 138290000.0 42119000.0 64753000.0 False True 114994262.28575256 41892096.58703306 78292552.91595559 1.0 0.3642972767018078 0.6808387771678918 26.77698663784768 -10.558250220042053 6.483487918524273 1.000652878156378 0.5225680269349471 0.7520576508279856 0.12922752642614488 0.0012210959961294935 8.319882809559406e-05 0.12528317409694384 0.041708004810003155 2.7653479230090292e-11 10.558250220042053 -0.47808485122143085 AYVVLGQFLVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYVVLGQFLVLK 12 0 O75531 O75531 BANF1 Barrier-to-autointegration factor;Barrier-to-autointegration factor, N-terminally processed 0 979770600.0 306630000.0 381810600.0 291330000.0 False True 396938579.5809271 360562504.47150815 238310929.298232 1.0 0.908358428783054 0.6003723033166284 28.564340547854354 -6.94887374963111 0.5710731372156724 1.003818219062905 0.4899107984003122 0.9991099191370384 0.005099583193231279 0.08394114277865077 0.03785831998411126 0.0053961070904512505 0.025668096191609733 1.1249319466500873e-07 6.94887374963111 -0.5139074206625929 AYYGNINFFGGPSNTSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYYGNINFFGGPSNTSVK 18 0 P56282;P56282-2;P56282-3 P56282 POLE2 DNA polymerase epsilon subunit 2 0 4611800.0 1636500.0 0.0 2975300.0 False True 1584550.2032748098 0.0 2195979.6729132663 1.0 0.0 1.3858694210980553 20.595641938648754 -6.713150539815012 1.7845030653969225 0.38719743286117475 1.38285015188641 0.47984498236823037 0.4211928889738222 0.3687622331049845 2.2911098647090817 0.18771608402786977 0.4749798451710177 1.935750856899894e-07 6.713150539815012 0.9956527190252353 AYYGNINFFGGPSNTSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYYGNINFFGGPSNTSVK 18 0 P56282;P56282-2;P56282-3 P56282 POLE2 DNA polymerase epsilon subunit 2 0 5913800.0 1619000.0 1403600.0 2891200.0 False True 2217588.0518298945 1341584.3109154964 2208358.1061330927 1.0 0.6049745397069833 0.9958378447750088 21.080559958818416 -10.914102318571608 10.386771448606316 1.0255827609925412 0.8004061922443589 0.2579855695823323 0.15956927609907678 0.0776529988362951 0.0006421824564142916 0.12691526013241283 0.05150076240817475 1.2187024421949207e-11 10.914102318571608 -0.22517656874818226 AYYGNINFFGGPSNTSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYYGNINFFGGPSNTSVK 18 0 P56282;P56282-2;P56282-3 P56282 POLE2 DNA polymerase epsilon subunit 2 0 1636500.0 1636500.0 0.0 0.0 False True 1360822.2592424185 0.0 0.0 1.0 0.0 0.0 20.37604721408303 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 AYYHLLEQVAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 AYYHLLEQVAPK 12 0 P13796 P13796 LCP1 Plastin-2 0 86059300.0 19378800.0 34173000.0 32507500.0 False True 25405794.464566123 29074521.605310723 29143935.733958617 1.0 1.1444051334769882 1.1471373498910313 24.59865424356734 AYYHLLEQVAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 AYYHLLEQVAPK 12 0 P13796 P13796 LCP1 Plastin-2 0 86911600.0 24486600.0 11122000.0 51303000.0 False True 23709286.286287177 15563072.600463774 37865205.24299038 1.0 0.6564125302019337 1.5970622137575947 24.498948898658117 -6.8078480232279714 1.4234634277144946 0.8122637876895002 1.6127356519803357 0.8541552899190976 0.1484194861904791 0.2097515645535119 0.8380354409237464 0.08199294281376547 0.1898666420815773 1.5565102206430716e-07 6.8078480232279714 0.8004718642908355 AYYHLLEQVAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYYHLLEQVAPK 12 0 P13796 P13796 LCP1 Plastin-2 0 119626600.0 5887700.0 110357000.0 3381900.0 False True 8932071.34852629 90662931.1268236 2713465.9826605734 1.0 10.150269471569118 0.3037891074513495 23.090563344639726 -6.662657658771171 1.963742307792752 6.8770006305742335 0.34483823922470014 0.24690211435508003 3.8935162180380596 0.47813869765396655 3.547338398691043 1.6004293805203242 4.316773021991459 2.1744145288119696e-07 6.662657658771171 -6.532162391349534 AYYHLLEQVAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 AYYHLLEQVAPK 12 0 P13796 P13796 LCP1 Plastin-2 0 104528800.0 19378800.0 35525000.0 49625000.0 False True 26543666.052378718 33955388.03453475 37904597.058956414 1.0 1.2792275176884178 1.4280091146475067 24.66186430509023 -11.98435580755672 0.096185814499179 5.068215480511168e-12 1.8046885885655217 0.999870820415718 0.0020164801608695063 5.6369855041841035 0.07090983597556925 1.4361820682520472 0.28085985748859726 1.0366787405746956e-12 11.98435580755672 1.8046885885604536 AYYHLLEQVAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 AYYHLLEQVAPK 12 0 P13796 P13796 LCP1 Plastin-2 0 46708700.0 24486600.0 14502900.0 7719200.0 False True 20361692.840308838 14424769.999099726 9333249.03045178 1.0 0.7084268539079356 0.45837294097548215 24.279354174092393 -7.09311201326968 0.18463068877968597 1.1899244117104542 5.345769730536571e-13 0.9999956345762976 0.0004624118971602753 0.07581930633975217 0.006500018509834519 0.01079420124987102 0.0292582006107256 8.070268549686822e-08 7.09311201326968 -1.1899244117099195 down AYYQGK(ub)MQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 AYYQGKMQR 9 1 Q8IZT6 Q8IZT6 ASPM Abnormal spindle-like microcephaly-associated protein 1 13145280.0 328280.0 0.0 12817000.0 True False 498024.7604827373 0.0 10283714.332109332 1.0 0.0 20.649002114154502 18.925857945520615 -6.895518843516844 0.9891449148492487 0.0328273270427623 22.62971328589507 0.9842030482805441 1.1949086703954224 0.11477884187606782 0.19659444673259996 0.9131036669317405 2.326629748477175 1.2719825590902517e-07 6.895518843516844 22.596885958852305 up AYYQGK(ub)MQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 AYYQGKMQR 9 1 Q8IZT6 Q8IZT6 ASPM Abnormal spindle-like microcephaly-associated protein 1 10872770.0 328280.0 2099390.0 8445100.0 True False 424964.93136622955 1982557.1009878733 6908178.454043515 1.0 4.665225186026774 16.255878883545172 18.696984267613065 -6.950260301220076 0.5559789489977806 0.8450974416804822 20.626132400864527 0.9992215503567141 0.18141874692505858 0.08338139487133339 0.03553114511229139 0.1954287911514991 0.9626777577429971 1.1213461564118282e-07 6.950260301220076 19.781034959184044 CADYVVTGAWSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CADYVVTGAWSAK 13 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 7663300.0 1523000.0 2336100.0 3804200.0 False True 2086094.2575274466 2232883.3775503607 2905726.309958326 1.0 1.070365526146885 1.392902693381819 20.992372915003145 -6.941761673942504 0.642969219507362 0.9964609437709633 1.484580684952674 0.9983856201274639 0.006873081073978078 0.08697212331121949 0.0510189078967949 0.006783347638061231 0.027551843820071947 1.1435056797102447e-07 6.941761673942504 0.48811974118171064 CAGLLMTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CAGLLMTLK 9 0 P04424;A0A5F9ZHM8;P04424-3;F8W943;H7C0S8;A0A5F9ZI35 P04424 ASL Argininosuccinate lyase 0 30404300.0 2638300.0 0.0 27766000.0 False True 3458836.849333544 0.0 24893040.670279033 1.0 0.0 7.196939825327545 21.721855533827558 -6.871759468379536 1.12480024885778 0.4279960904211656 7.632665655881782 0.9664051881663306 0.5834552113156389 0.1351762437002152 0.31857352823916024 0.40213475851879243 0.9550497914562206 1.3435088501385808e-07 6.871759468379536 7.204669565460616 up CAILTTLIHLVQGLGADSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CAILTTLIHLVQGLGADSK 19 0 F8WDV0;Q9UI26;Q9UI26-2 F8WDV0 IPO11 Importin-11 0 1882220000.0 770600000.0 560350000.0 551270000.0 False True 1169056538.40623 460351164.46546763 442311242.8697751 1.0 0.39378006909149366 0.3783488893298319 30.12269755777016 CAILTTLIHLVQGLGADSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CAILTTLIHLVQGLGADSK 19 0 F8WDV0;Q9UI26;Q9UI26-2 F8WDV0 IPO11 Importin-11 0 1268270000.0 770600000.0 250110000.0 247560000.0 False True 997556890.7969303 236191158.63563997 202506620.18010616 1.0 0.23676961265532542 0.2030025776457995 29.89382387986261 -13.331845673902142 0.4514884998738307 9.998706026001654 0.2031077299978908 0.9998902575294287 0.0038551702127687893 19.121229002712145 0.22835362838776396 167.95747446948482 0.007599873433756588 4.6575156846178336e-14 13.331845673902142 -9.795598296003764 CALNK(ub)SNDFEELVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CALNKSNDFEELVER 15 1 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 1 9549600.0 4123900.0 4002100.0 1423600.0 True False 3429205.569746292 3980539.8929453483 1721268.178017302 1.0 1.160776107464402 0.501943713495324 21.70944296107629 -6.842197549504619 1.2721442748609755 1.0855194037046856 0.479313356761946 0.9281688755111807 0.0751696004465497 0.1662466871630452 0.5216699237601071 0.046315714440293684 0.10677398731755584 1.4381442542369371e-07 6.842197549504619 -0.6062060469427396 CALSSPSLAFTPPIK(ub)TLGTPTQPGSTPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CALSSPSLAFTPPIKTLGTPTQPGSTPR 28 1 Q8NFH5-2;Q8NFH5;Q8NFH5-3 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 10451800.0 3216800.0 5003000.0 2232000.0 True False 4217255.951535515 4256571.9015412545 2001054.0508558233 1.0 1.0093226378615756 0.4744919620368866 22.007873152905958 -6.902934022905757 0.9425298655598929 1.0204818424456787 0.41488319678427 0.9879704123681342 0.027414736615584294 0.10927780609428503 0.16548866450206992 0.02168851933787128 0.057307791363387116 1.2504489813392625e-07 6.902934022905757 -0.6055986456614088 down CALSSPSLAFTPPIK(ub)TLGTPTQPGSTPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CALSSPSLAFTPPIKTLGTPTQPGSTPR 28 1 Q8NFH5-2;Q8NFH5;Q8NFH5-3 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 15105000.0 6711200.0 5966200.0 2427600.0 True False 6498156.629525144 8348534.77332199 1791738.7335610692 1.0 1.2847543156145904 0.27573030871864374 22.631599087678524 -6.831328441928695 1.3219232874259184 1.1520181877198465 0.24782522724059342 0.9085182395075209 0.1284723701644418 0.17917298097240034 0.6118682819674854 0.0762954197988107 0.1755770721562628 1.4745909292525772e-07 6.831328441928695 -0.9041929604792531 down CAMTALSSK(ub)LISQQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CAMTALSSKLISQQK 15 1 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 1 44724400.0 12147000.0 8408400.0 24169000.0 True False 18427887.064651515 6907855.32487095 19391986.556351002 1.0 0.37485878335566963 1.0523174191548432 24.135387325733497 -12.025917376978617 18.620164761206773 0.9211919798822188 0.7422292911297891 0.0 0.31493992838621765 0.0 0.0 0.0 0.09166009797852877 9.42068804803506e-13 12.025917376978617 -0.1789626887524297 CAMTALSSK(ub)LISQQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CAMTALSSKLISQQK 15 1 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 1 12495900.0 3286300.0 5283100.0 3926500.0 True False 4501333.918918218 5049675.173124577 2999141.5688058934 1.0 1.121817502119047 0.6662784016535839 22.101921160330363 -6.835557548303461 1.3029552011643484 1.0648844153847992 0.6525739775016169 0.9165254951459881 0.055635289575372386 0.17405423777972434 0.5759149577203332 0.03350513239829986 0.07711787437548298 1.4603012323003113e-07 6.835557548303461 -0.4123104378831822 CAMTALSSK(ub)LISQQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CAMTALSSKLISQQK 15 1 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 1 16039400.0 7790600.0 5090100.0 3158700.0 True False 6478229.082098373 5062678.62099425 3819169.5658213375 1.0 0.7814911385249116 0.5895391344488029 22.62716805471009 -6.972648327339067 0.18425580571615818 1.140276187442915 0.22554110152494972 0.9999963477206474 0.00032041321703913777 0.07545235929612215 0.005838983927566382 0.007120737025180657 0.021269702355781274 1.0650050636356138e-07 6.972648327339067 -0.9147350859179653 CAMTALSSK(ub)LISQQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CAMTALSSKLISQQK 15 1 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 1 47017000.0 12147000.0 10927000.0 23943000.0 True False 15724530.953166751 10318902.844395025 19585619.675926168 1.0 0.6562296118802138 1.2455455577186443 23.906513647825946 -6.748573098118813 1.655021317312247 0.79751351538368 1.2465975100671245 0.6428402786567754 0.14444595993303047 0.3025460884746076 1.6300084606318725 0.0689570084735599 0.1676673998693255 1.78413166778982e-07 6.748573098118813 0.4490839946834445 CAQAK(ub)QWGWTQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CAQAKQWGWTQGR 13 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 45832000.0 12031000.0 11417000.0 22384000.0 True False 15772757.508369718 9713628.103117442 20067918.4024896 1.0 0.6158484398154834 1.2723151542677733 23.910931568847072 -6.7481211843604205 1.657073687693058 0.7736036389852238 1.2734138353204443 0.6407460823220551 0.1614092774366479 0.3033272506640083 1.6381955763334297 0.07697070216840358 0.18721399422964038 1.7859891477225646e-07 6.7481211843604205 0.4998101963352205 CAQAK(ub)QWGWTQGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CAQAKQWGWTQGR 13 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 27116200.0 12506000.0 6032000.0 8578200.0 True False 12109003.87543829 8440609.056464454 6331312.079516216 1.0 0.6970523044909789 0.5228598606990744 23.529576853515124 -11.078482998011701 0.08928860494543715 2.015918391241776 9.382810946394254e-11 0.9999251532668135 0.0017055405418528499 3.5056431732520092 0.05538024950375698 1.0649595131597571 0.3387433005100441 8.346742239022802e-12 11.078482998011701 -2.015918391147948 CAQAK(ub)QWGWTQGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CAQAKQWGWTQGR 13 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 57460000.0 11312000.0 14959000.0 31189000.0 True False 17161131.017974652 12289449.57479955 25024480.479375675 1.0 0.7161211904930695 1.4582069476169672 24.032641302145283 -6.803003206239597 1.4434975153517786 0.8439645038849997 1.4692424689214179 0.8408415777455776 0.12196956203703867 0.2164912561237713 0.8902228720524584 0.0664615662147029 0.1542996355980698 1.5739712443610435e-07 6.803003206239597 0.6252779650364182 CAQAK(ub)QWGWTQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CAQAKQWGWTQGR 13 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 38999600.0 12031000.0 9115600.0 17853000.0 True False 16479185.825550005 8712842.650741868 13636489.09407657 1.0 0.5287180290929858 0.8274977440289555 23.974141630369964 -10.39653054277136 6.44620597254235 1.0000414592953903 0.6781078865609715 0.6074728607442023 0.12197630784788997 7.268742951212505e-05 6.8048625351913015e-06 0.11811821736554229 0.039367684077228904 4.013002748934407e-11 10.39653054277136 -0.3219335727344188 CAQAK(ub)QWGWTQGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CAQAKQWGWTQGR 13 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 38314500.0 12506000.0 6672400.0 19136100.0 True False 10399293.109737659 6636454.456832295 23137370.034670442 1.0 0.6381639969949565 2.224898345542847 23.3099821289494 -6.846740362378925 1.250593499406746 0.8073066206632964 2.2844910357801433 0.9354363180939942 0.17252261313599837 0.16108682334959754 0.48643665572559286 0.10802707932386166 0.24953387444329522 1.4231793631440063e-07 6.846740362378925 1.477184415116847 up CAQAK(ub)QWGWTQGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CAQAKQWGWTQGR 13 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 64641800.0 11312000.0 22790800.0 30539000.0 True False 14643606.992856048 21522471.94527667 24981215.356601454 1.0 1.4697520874314989 1.7059468591849438 23.803767624237732 -10.700778149085982 0.13429010906378158 7.134141977585763e-20 2.098553539890135 0.9997556067955395 0.004586931385956091 2.702854048292589 0.07481164987670358 1.119160921172481 0.25551270703376916 1.991690495633499e-11 10.700778149085982 2.098553539890135 CAQAQTGIDLSGCTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CAQAQTGIDLSGCTK 15 0 Q8N163;Q8N163-2;H0YB24;G3V119;E5RHJ4 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 0 3797010.0 478410.0 1881200.0 1437400.0 False True 627200.1429290308 1600532.2928601657 1288671.636514408 1.0 2.551868507850882 2.0546418093852767 19.25856636265744 -9.956614042917597 6.590279823866445 0.9999998268708425 2.3032551586180983 0.9015734317105134 0.20299194962164188 5.168264981907644e-07 8.177087601968261e-08 0.19654613643216653 0.06551537002488948 1.1050602496166049e-10 9.956614042917597 1.3032553317472557 CAQAQTGIDLSGCTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CAQAQTGIDLSGCTK 15 0 Q8N163;Q8N163-2;H0YB24;G3V119;E5RHJ4 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 0 478410.0 478410.0 0.0 0.0 False True 655291.1055441271 0.0 0.0 1.0 0.0 0.0 19.32177642418033 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 CATPLK(ub)DEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CATPLKDEER 10 1 H0Y4W2;F2Z2U4;Q9Y4A5-2;Q9Y4A5 H0Y4W2 TRRAP Transformation/transcription domain-associated protein 1 1452210.0 483670.0 347060.0 621480.0 True False 662495.8696902808 331725.7416260561 474699.22378237254 1.0 0.5007212222789239 0.7165315974034618 19.33755193459107 -10.286127976853367 5.682334864060059 1.000034366209286 0.6086264098411888 0.8143016005249012 0.08810421670897392 3.83614085024573e-05 4.819338372074957e-06 0.08531401427526743 0.028435513670373048 5.174543272852286e-11 10.286127976853367 -0.39140795636809733 CATPLK(ub)DEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CATPLKDEER 10 1 H0Y4W2;F2Z2U4;Q9Y4A5-2;Q9Y4A5 H0Y4W2 TRRAP Transformation/transcription domain-associated protein 1 4409750.0 611850.0 1245600.0 2552300.0 True False 792051.8863665989 1176281.2650296004 2087807.5888095186 1.0 1.485106323558659 2.635948003844767 19.59523541705465 -6.9565748470391435 0.48128434211766385 0.972707694994028 3.196432469807776 0.9996213144703693 0.013350596776387095 0.08094813154787159 0.025830502204815156 0.016269048749980336 0.09493065678447529 1.1051599878441593e-07 6.9565748470391435 2.223724774813748 CAVIK(ub)TSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CAVIKTSTR 9 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 7478400.0 1647600.0 2456100.0 3374700.0 True False 2160019.555381096 2089659.4538028163 3025518.4164082184 1.0 0.9674261738033821 1.4006902895258377 21.042612942973854 -6.8887816421155526 1.0295936481065846 0.9760355874148834 1.4370733327043155 0.9801058221385315 0.027788214565316743 0.12013600746761662 0.2276817500631409 0.020597217890155707 0.05112760729107732 1.2918686459001595e-07 6.8887816421155526 0.4610377452894321 CAVIK(ub)TSTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CAVIKTSTR 9 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 9431100.0 3354000.0 3216200.0 2860900.0 True False 3247529.10588678 4500445.432261437 2111544.4648397015 1.0 1.3858060345336094 0.6502003203026311 21.630911025168338 -6.764169740199286 1.596547888392439 1.2229290992167827 0.6469221907654059 0.7078522160688343 0.1623843303122735 0.2759615703483779 1.3871873426792274 0.0802120486931471 0.19199455319863243 1.7211957292119284e-07 6.764169740199286 -0.5760069084513768 CAVIK(ub)TSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CAVIKTSTR 9 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 6452900.0 1647600.0 1040200.0 3765100.0 True False 2256762.244715835 994240.5245185932 2875860.9246685533 1.0 0.44056059819619375 1.274330484481618 21.105823004496745 -6.7259251554177535 1.7382745565673217 0.6618135503402104 1.2734610690420487 0.5402246396653214 0.23525907484016073 0.343914779321563 2.0339146910786225 0.10734163639141596 0.2675796125470617 1.879640718691795e-07 6.7259251554177535 0.6116475187018383 CAVIK(ub)TSTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CAVIKTSTR 9 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 7954500.0 3354000.0 2707500.0 1893000.0 True False 2788999.607393263 2692914.1601033253 2288817.547756918 1.0 0.965548418495568 0.8206589709405373 21.411316300602614 -6.9437246389795 0.6239516811763364 1.001582341207986 0.7768968676473563 0.9986121700196443 0.0028947968585050082 0.08610779617351647 0.04717521907179589 0.0029048593305590737 0.012280560312817901 1.1383488182257108e-07 6.9437246389795 -0.22468547356062973 CAVSSK(ub)YQTVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CAVSSKYQTVEK 12 1 Q9H0S4;Q9H0S4-2;F5H1N9 Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 1 2678590.0 826210.0 727980.0 1124400.0 True False 687030.2223090004 724058.2272472837 1359506.841361795 1.0 1.0538957439366174 1.9788166476762938 19.390014038714966 -6.918866520929719 0.8330927830635698 0.9787467658458829 2.1241468463899458 0.993860206582573 0.035202150141022306 0.0988431818529772 0.10910469941848643 0.030149642270014425 0.0893563903829412 1.205406361374454e-07 6.918866520929719 1.145400080544063 CAVSSK(ub)YQTVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CAVSSKYQTVEK 12 1 Q9H0S4;Q9H0S4-2;F5H1N9 Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 1 15510000.0 1765900.0 1775100.0 11969000.0 True False 2285992.3610930396 1676314.124561691 9790764.812310915 1.0 0.7332982179171268 4.282938551741045 21.124389151952855 -6.888793075129421 1.0295155909886191 0.803717208705047 4.581095703507822 0.9801136880662734 0.22762283443441308 0.12012720681885329 0.22762153235763105 0.16872768739515248 0.4188464800020135 1.2918346372761764e-07 6.888793075129421 3.7773784948027753 up CAYQILVQVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CAYQILVQVK 10 0 P53041;H0YDU8 P53041 PPP5C Serine/threonine-protein phosphatase 5;Serine/threonine-protein phosphatase 0 11959100.0 4479300.0 3907500.0 3572300.0 False True 5798542.150203334 3690044.1900314395 2922178.054893332 1.0 0.6363744704178865 0.5039504722391062 22.467258797660303 -13.999999999999998 0.1404911821141159 2.737745196239639 0.34103457791811354 0.9996009822887189 0.00418914995259905 11.93452824446015 0.11747069236687853 5.683999640041139 0.14569326764987292 1.0000000000000041e-14 13.999999999999998 -2.3967106183215257 CCHLFSTYVASHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CCHLFSTYVASHK 13 0 Q9H3P7 Q9H3P7 ACBD3 Golgi resident protein GCP60 0 12915300.0 3805300.0 4449700.0 4660300.0 False True 4988785.150577623 3785822.1047947477 4178096.8607542096 1.0 0.7588665357449615 0.8374978546170607 22.25025710820938 -10.434823044136955 8.384866075838703 1.0000036815134714 0.7981821951810112 0.8977868692380357 0.03210110150645338 2.209277429373108e-06 1.4892420184566738e-07 0.03108232463427867 0.010360585960783982 3.6743198234258214e-11 10.434823044136955 -0.20182148633246022 CCHLFSTYVASHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CCHLFSTYVASHK 13 0 Q9H3P7 Q9H3P7 ACBD3 Golgi resident protein GCP60 0 11878900.0 3805300.0 3432500.0 4641100.0 False True 5212222.2443658495 3280840.8002404096 3544967.766454861 1.0 0.6294514405610455 0.6801259808686771 22.31346716973227 -10.103054410269381 5.100659775620881 1.000009184821052 0.6547887107143371 0.9840959260280484 0.02068779445327548 2.1608643521360396e-06 3.799811914982361e-07 0.02003140370651788 0.006676956948562229 7.887612920412722e-11 10.103054410269381 -0.34522047410671486 CCHLFSTYVASHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CCHLFSTYVASHK 13 0 Q9H3P7 Q9H3P7 ACBD3 Golgi resident protein GCP60 0 5166800.0 1398500.0 1811600.0 1956700.0 False True 1810385.8185563257 1710782.8674756126 1600600.6774374438 1.0 0.9449824727636562 0.8841213077518619 20.787865757904523 -6.969827164626486 0.26234452798686425 1.0166050857295232 0.8106876477903598 0.9999809664610512 0.00020639628896875056 0.07635938267741299 0.009233715960910716 0.0012515101993715542 0.005722374483489881 1.0719458206622736e-07 6.969827164626486 -0.2059174379391634 CCLFPFGLHCTGMPIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CCLFPFGLHCTGMPIK 16 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;A0A6I8PRS0;Q9P2J5-2;A0A6I8PLB3;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 5740700.0 1261200.0 2574500.0 1905000.0 False True 1653445.413478173 2190394.6353223985 1707888.8740503346 1.0 1.3247456598610678 1.0329272802890026 20.65704398678893 -9.956219579656459 6.059230054349184 0.9999999152869494 1.178836470075064 0.33366889219562157 0.11913435458633266 1.3621524617227184e-07 2.3545278595682845e-08 0.11535139782213243 0.038450447606154625 1.1060644154793518e-10 9.956219579656459 0.17883655478811455 CCLFPFGLHCTGMPIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CCLFPFGLHCTGMPIK 16 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;A0A6I8PRS0;Q9P2J5-2;A0A6I8PLB3;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 5904600.0 1261200.0 2472300.0 2171100.0 False True 1727499.7226484646 2363065.6111971894 1658330.8952080656 1.0 1.3679108483874753 0.9599601513484732 20.720254048311823 -6.669129475954467 1.940609981054393 1.2350109690894162 0.961619750059852 0.2751786465042425 0.15631171924152296 0.4630893391288148 3.3614372594060935 0.06486717558478314 0.17349625469974655 2.142251837647006e-07 6.669129475954467 -0.2733912190295642 CCLTYCFNK(ub)PEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CCLTYCFNKPEDK 13 1 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 58775000.0 24082000.0 24456000.0 10237000.0 True False 31571735.210419767 20807260.128741357 9177773.44023793 1.0 0.6590470872147135 0.29069588285438763 24.91213021883368 -7.333170167285117 0.3118876104232254 1.0711991776910847 3.6124562447414145e-11 0.9998103282062867 0.0039890157161416575 0.10837863496425812 0.02380875274061652 0.014324228245787761 0.05200761375289901 4.643333023388046e-08 7.333170167285117 -1.07119917765496 down CCLTYCFNK(ub)PEDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CCLTYCFNKPEDK 13 1 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 113693000.0 49870000.0 31724000.0 32099000.0 True False 75656435.98536022 26062604.339256685 25754618.58050852 1.0 0.34448628196416614 0.34041543518507966 26.17295947988836 CCLTYCFNK(ub)PEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CCLTYCFNKPEDK 13 1 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 60105000.0 24082000.0 23998000.0 12025000.0 True False 32985766.191579744 22937689.00922629 9184942.662648879 1.0 0.6953814222778787 0.2784516997211213 24.975340280356573 -7.1608083060273255 0.36436432731076224 1.039394467506356 5.4442098673995065e-14 0.999840425721059 0.003736090060544663 0.08347317537408804 0.01960046989375919 0.007814351196365423 0.03950539951754328 6.905445371979892e-08 7.1608083060273255 -1.0393944675063016 down CCLTYCFNK(ub)PEDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CCLTYCFNKPEDK 13 1 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 111410000.0 49870000.0 37240000.0 24300000.0 True False 64557698.08466498 35167561.26340907 19877649.339055516 1.0 0.5447462085356288 0.30790517519671673 25.94408580198081 -9.744291346616945 0.1651157514984809 1.6197721403523944 1.5538609213489626e-12 0.999682057786773 0.00512100784459758 1.2162446283293358 0.0704629372793713 0.5204851015065348 0.17592846787307587 1.801808591352793e-10 9.744291346616945 -1.6197721403508405 CCLTYCFNKPEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CCLTYCFNKPEDK 13 1 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 0 209759400.0 58345900.0 65481300.0 85932200.0 False True 76492039.92249934 55711745.28410828 77040760.26386778 1.0 0.7283338938346348 1.0071735613525852 26.188806287025336 -10.998977258422336 10.62342116136663 1.1289788333665558 0.8677537275635544 0.2307182429634217 0.11383581757771521 0.06355152955974001 6.118264088452526e-06 0.02014315426773568 0.03674035214003304 1.0023577245822702e-11 10.998977258422336 -0.2612251058030014 CCLTYCFNKPEDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CCLTYCFNKPEDK 13 1 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 0 125049000.0 15224000.0 101600800.0 8224200.0 False True 23095921.02348359 83469343.42932646 6598683.265205088 1.0 3.6140296524419213 0.28570773421400447 24.461134743609907 -6.697252198683822 1.8405094335729475 2.6275827647184498 0.29606602021530065 0.4045392818665309 1.103984512173771 0.4013101334759344 2.6409214394521974 0.47886243925184924 1.2357751637144019 2.007926453162016e-07 6.697252198683822 -2.331516744503149 CCLTYCFNKPEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CCLTYCFNKPEDK 13 1 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 0 138219300.0 58345900.0 39430700.0 40442700.0 False True 79917955.96866086 37688521.294111975 30890967.203551747 1.0 0.471590155645262 0.38653349962635897 26.252016348548228 -13.999999999999988 0.2570662084226568 4.80976860999827 0.3545610536024294 0.9995564065663451 0.005715575307657773 14.289353035370082 0.16043744338755994 28.230254290425126 0.0377691480306846 1.0000000000000286e-14 13.999999999999988 -4.45520755639584 CCLTYCFNKPEDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CCLTYCFNKPEDK 13 1 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 0 37766000.0 15224000.0 15431000.0 7111000.0 False True 19707768.109904587 14572251.285060829 5816870.9650215525 1.0 0.7394166200756752 0.2951562517167102 24.232261065702357 -6.981012630024334 0.39409706249584325 1.026371352336106 2.4660282665256793e-11 0.9998678416063207 0.003345218778296007 0.07622869747121702 0.017270474868011636 0.0056728592512236345 0.03618801264380151 1.0446898374165677e-07 6.981012630024334 -1.0263713523114457 down CCLTYCFNKPEDK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 CCLTYCFNKPEDK 13 1 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 54941000.0 15191000.0 27145000.0 12605000.0 True False 19915548.109853238 23095071.81038124 11300755.51569787 1.0 1.1596503236059534 0.5674338187110607 24.247391849888306 -6.834937124221373 1.3057500855839035 1.085059200324231 0.5498343654548342 0.9153836409873441 0.07277535152521976 0.17479763083613248 0.5810995695301647 0.04373676486882617 0.10066234141252339 1.4623888791583768e-07 6.834937124221373 -0.5352248348693968 CCLTYCFNKPEDK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 CCLTYCFNKPEDK 13 1 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 78594000.0 43780000.0 24144000.0 10670000.0 True False 66417460.746723 19835314.56206698 8561069.823172864 1.0 0.29864608401256354 0.12889787906556277 25.985059231404193 -13.999999999999371 0.19927169771077205 4.8879825316339165 0.01786118768833024 0.9994869134816283 0.008540814680415265 12.516598862505008 0.14154872752066058 18.961731075849958 0.10867673090726916 1.0000000000014479e-14 13.999999999999371 -4.870121343945586 CCLTYCFNKPEDK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CCLTYCFNKPEDK 13 1 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 53738000.0 15191000.0 27116000.0 11431000.0 True False 20807523.221339043 25917925.45937913 8731233.228834892 1.0 1.2456035821120286 0.4196190548945596 24.310601911411197 -6.827026540568734 1.3411082457350816 1.1315279184873004 0.3987064716221112 0.899805570355652 0.10962118091738009 0.18450668986635058 0.6500410837269452 0.06419683903080278 0.14776823941218892 1.4892700627800488e-07 6.827026540568734 -0.7328214468651892 down CCLTYCFNKPEDK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CCLTYCFNKPEDK 13 1 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 79128300.0 43780000.0 27320000.0 8028300.0 True False 56674073.03281808 25799617.98378991 6567231.777314373 1.0 0.4552278776372788 0.11587718026744799 25.756185553496643 -8.392494366821204 0.35333841393237875 1.118530011641347 5.368999809675187e-19 0.9979616553017964 0.016441768321265707 0.13949632376989327 0.09660116641876043 0.09227554011625275 0.08734605194973814 4.050471989184078e-09 8.392494366821204 -1.118530011641347 CCSGAIIVLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CCSGAIIVLTK 11 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 569273500.0 184140000.0 178390000.0 206743500.0 False True 241409323.21429655 151774907.3587738 185351665.84368774 1.0 0.6287035866632408 0.7677900065158336 27.846906153067962 -10.270397994635719 6.0921959747598855 1.0000108336127527 0.6982467965895367 0.8625591499579267 0.05678179313156194 8.355558132801671e-06 1.0006317492033596e-06 0.054980707122955656 0.018326244930527577 5.365398769987642e-11 10.270397994635719 -0.30176403702321597 CCSGAIIVLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CCSGAIIVLTK 11 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 100782000.0 72736000.0 17669000.0 10377000.0 False True 70427035.49367349 24724323.842617787 7658952.396672933 1.0 0.3510629642339381 0.10875017446050164 26.06962602042184 -9.748816822340826 0.2727736776328574 1.4550990216860296 3.423463489961012e-14 0.9989019423340951 0.012468190510906318 1.1653417131434547 0.11809257407893047 0.5305187422337255 0.09507296070338116 1.783130701557118e-10 9.748816822340826 -1.4550990216859954 CCSGAIIVLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CCSGAIIVLTK 11 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 681070500.0 126530000.0 357513000.0 197027500.0 False True 191955260.5820663 293712011.88818145 158084928.26477912 1.0 1.5301066039948994 0.8235509034001876 27.51619485724502 -6.705963482527015 1.8098332963348642 1.3272446128634636 0.8254201638299552 0.44575312935437394 0.22353183099633694 0.38327459475726183 2.444662444450782 0.0983881915671584 0.2511609053536071 1.96805176557346e-07 6.705963482527015 -0.5018244490335084 CCSGAIIVLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CCSGAIIVLTK 11 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 627501600.0 184140000.0 265770000.0 177591600.0 False True 252221534.196391 254027402.61613786 135648121.693811 1.0 1.0071598502701231 0.5378134033083365 27.910116214590854 -6.90343669562593 0.9392803406360775 1.0177166403200533 0.4849586475933564 0.988200040048745 0.023852875845184127 0.10891979800936834 0.16349416349961376 0.01891592605350498 0.05012163951384081 1.2490024905566183e-07 6.90343669562593 -0.5327579927266969 CCSGAIIVLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CCSGAIIVLTK 11 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 142579760.0 72736000.0 3948300.0 65895460.0 False True 60483206.7511498 3927029.724223811 79673896.01981737 1.0 0.06492760445690418 1.3172895469584662 25.850031295856116 -6.706854579732752 1.8065799753577931 0.4232856659520112 1.3140593568327215 0.4500383011484672 0.39423575788506854 0.38145382436486164 2.4248663449248973 0.17379574765296826 0.4431882165674897 1.9640178034550583e-07 6.706854579732752 0.8907736908807102 CCSGAIIVLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CCSGAIIVLTK 11 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 532064800.0 126530000.0 262124800.0 143410000.0 False True 163795579.27917933 247537324.4537821 117310851.51086198 1.0 1.5112576636263804 0.7162027939161469 27.287321179337468 -6.73306113387054 1.7121725983259521 1.3066159323374058 0.7164116691506695 0.5733912471476629 0.21487281053308202 0.33050957866203007 1.89953137840834 0.0993986811873353 0.2457911413885024 1.8490083232653133e-07 6.73306113387054 -0.5902042631867364 CCSGAIIVLTK(ub)SGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CCSGAIIVLTKSGR 14 1 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 63254000.0 2117000.0 11026000.0 50111000.0 True False 3211643.773431078 9058324.153468806 40206538.88556851 1.0 2.8204635359641945 12.518990810308601 21.614880451343474 -6.938400766781451 0.6742812555351333 0.8875386672072669 15.015722036590125 0.9979467920241198 0.22909641461955949 0.08850391007834803 0.057990117337227975 0.22039303920617395 0.8407847945341544 1.152389342562646e-07 6.938400766781451 14.128183369382858 CDENILWLDYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CDENILWLDYK 11 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BUW1;H3BTJ2 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 126170000.0 25434000.0 45300000.0 55436000.0 False True 33344220.303206332 38541416.57801699 49700014.49966104 1.0 1.155864981323642 1.4905136196836477 24.99093337876921 -6.9586338989282295 0.45427778751062736 0.9896678387898288 1.6700724114059753 0.999716126450885 0.0034478336406949476 0.08019278276502326 0.022962078592756896 0.004502403993605197 0.027664384366350395 1.099932668727467e-07 6.9586338989282295 0.6804045726161465 CDENILWLDYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CDENILWLDYK 11 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BUW1;H3BTJ2 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 37240400.0 20314000.0 6142400.0 10784000.0 False True 19669143.18932141 8595092.352192834 7959346.886934651 1.0 0.43698356707572306 0.40466159660965134 24.22943077772834 -13.891097280184264 0.40757762971348505 9.999851400878018 0.40307389297256746 0.9998465417103726 0.003386152615125488 25.420785370299704 0.21110047754238873 202.21401642633737 0.008104708761270925 1.2849987932404114e-14 13.891097280184264 -9.59677750790545 CDENILWLDYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CDENILWLDYK 11 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BUW1;H3BTJ2 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 148269000.0 15693000.0 108780000.0 23796000.0 False True 23807428.311976343 89367359.09798083 19092710.169842675 1.0 3.7537594538518264 0.8019644087403626 24.504908452735037 -6.661791831018374 1.9666164625116882 2.7699375017882404 0.8142471169961171 0.24324451760731614 1.1719869934020557 0.4801903644443302 3.572036521965908 0.4811678625442957 1.2994096555560612 2.1787538572053515e-07 6.661791831018374 -1.9556903847921232 CDENILWLDYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CDENILWLDYK 11 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BUW1;H3BTJ2 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 105470000.0 25434000.0 34939000.0 45097000.0 False True 34837637.128005885 33395279.4521776 34446017.40186918 1.0 0.9585977180217892 0.9887587173407382 25.0541434402921 -10.058774811677196 4.510990847148096 1.0000014943663493 0.9736782176796321 0.5038439594345234 0.012313176416190858 17072100.962147146 1.2560077739991549 264.9864039021913 0.0042151277977283885 8.734241347504301e-11 10.058774811677196 -0.02632327668671719 CDENILWLDYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CDENILWLDYK 11 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BUW1;H3BTJ2 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 39169700.0 20314000.0 3716700.0 15139000.0 False True 16891991.062786736 3696677.399392808 18304494.905172758 1.0 0.21884201724074043 1.0836197365447218 24.009836053162616 -6.668806808554996 1.9418080239161617 0.5008675525078454 1.0800887548534739 0.27365201386001503 0.33191271616131013 0.4638831231608079 3.3710614981593974 0.13767067150150378 0.3683672314887738 2.1438440560724272e-07 6.668806808554996 0.5792212023456285 CDENILWLDYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CDENILWLDYK 11 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BUW1;H3BTJ2 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 64768000.0 15693000.0 32619000.0 16456000.0 False True 20314897.855276708 30803723.975594506 13461176.852818811 1.0 1.5163120284945646 0.6626258693849316 24.276034774827487 -6.742939313273176 1.6757169925827857 1.3061453636407667 0.661773939981804 0.6181829686008005 0.21692385082135177 0.3125101389924439 1.7240915367370633 0.1023589052671331 0.2503948928234581 1.8074266715761648e-07 6.742939313273176 -0.6443714236589627 CDEPILSNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CDEPILSNR 9 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 8903010.0 3123000.0 872810.0 4907200.0 False True 3023862.074443771 1221327.5846440222 3621857.1071555754 1.0 0.40389659137104694 1.1977586999637884 21.527960905624564 -6.7057319703037335 1.8100954198666988 0.631957068698927 1.195699272964298 0.4450202836264193 0.2513669724677869 0.3836872457306829 2.447725185479071 0.11061709991034946 0.2825175630308832 1.9691011675867863e-07 6.7057319703037335 0.5637422042653709 CDISAEIQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CDISAEIQQR 10 0 P29590;P29590-4;P29590-2;P29590-5;P29590-9;P29590-3;P29590-8;P29590-11;H3BT57;P29590-14;P29590-10;P29590-12;P29590-13 P29590 PML Protein PML 0 2983600.0 0.0 1414700.0 1568900.0 False True 0.0 1203632.2744574095 1406565.2779514813 0.0 CDLLSK(ub)SQALNVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CDLLSKSQALNVR 13 1 C9JWL4;C9JC87;O00189;C9IZL5;H7C0A0;H7BZV3 C9JWL4 AP4M1 AP-4 complex subunit mu-1 1 7223500.0 3088300.0 2612000.0 1523200.0 True False 4048791.2071397407 2222299.7814962566 1365593.875566125 1.0 0.548879818148537 0.3372843413505745 21.949059815650255 -11.673641724691944 0.13025952286067757 2.223221987433734 7.186814472157989e-19 0.9997255937724592 0.004578292703693536 4.6844690962612665 0.08647448448849926 1.8570700428160396 0.24804085374039378 2.120109418176758e-12 11.673641724691944 -2.223221987433734 CDPAGYYCGFK(ub)ATAAGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CDPAGYYCGFKATAAGVK 18 1 G3V5Z7;P60900;G3V295;P60900-2;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 18359100.0 4768000.0 7987700.0 5603400.0 True False 6250894.173377675 6795966.29581074 5023613.919608208 1.0 1.0871990642162057 0.8036632488522351 22.57563114745512 -6.824136755048832 1.3538588966594485 1.0468136183000742 0.79690552379265 0.8936388118809458 0.038671562485436295 0.18816016826185522 0.6765173518213433 0.022439370872378385 0.05167160383747156 1.4992126738827381e-07 6.824136755048832 -0.24990809450742424 CDPAGYYCGFK(ub)ATAAGVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CDPAGYYCGFKATAAGVK 18 1 G3V5Z7;P60900;G3V295;P60900-2;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 59726000.0 16573000.0 18004000.0 25149000.0 True False 25142452.64859384 14791045.534105964 20178289.126801718 1.0 0.5882896844168142 0.8025585017033031 24.583622055870155 -10.52268646912776 7.621669346332833 1.000070107796351 0.6954240930600717 0.7292972380874334 0.08747487835692293 0.00010423277398304796 6.527644816270884e-06 0.08471655431837014 0.02823239559065682 3.0013284906690845e-11 10.52268646912776 -0.3046460147362793 CDPAGYYCGFK(ub)ATAAGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CDPAGYYCGFKATAAGVK 18 1 G3V5Z7;P60900;G3V295;P60900-2;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 18371700.0 4768000.0 6937300.0 6666400.0 True False 6530858.450355117 6630787.147416693 5091933.618817681 1.0 1.0153010048864468 0.7796729415473407 22.63884120897801 -6.891395958574204 1.0141056312989196 1.0122401649805373 0.7588450008449859 0.9817762286267895 0.0145323993996631 0.11801715281658975 0.2152987370622487 0.01089860146105873 0.02731009559809101 1.2841153617427595e-07 6.891395958574204 -0.2533951641355514 CDPAGYYCGFK(ub)ATAAGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CDPAGYYCGFKATAAGVK 18 1 G3V5Z7;P60900;G3V295;P60900-2;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 50501000.0 16573000.0 15627000.0 18301000.0 True False 21454075.202669993 14757343.712763 14970405.784117473 1.0 0.6878573685118073 0.6977884454443594 24.354748377962604 -10.022821079780233 5.029091799633606 1.0000036612374636 0.6928229069766458 0.9992166842423866 0.004054345188866504 5601218.069088818 1.7806831149028135 242.69433623228997 0.0013879101960873174 9.48809272317301e-11 10.022821079780233 -0.3071807542608178 CDQLQAEQK(ub)GLTEVTQSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CDQLQAEQKGLTEVTQSLK 19 1 B8ZZD4;Q86VP1-3;Q86VP1-4;Q86VP1-2;Q86VP1 B8ZZD4 TAX1BP1 Tax1-binding protein 1 1 6815700.0 1419400.0 2855600.0 2540700.0 True False 1860847.1454891511 2429555.6110416153 2277812.7361153187 1.0 1.3056180444111494 1.2240729936561028 20.827528123108312 -10.081541325570026 4.505830004815095 0.9999810978124911 1.2648455189932224 0.9336194103426643 0.033290627612337316 23130802.624909054 0.3036320898971888 4621.191885511485 0.011396267303657791 8.288170459029957e-11 10.081541325570026 0.2648644211807313 CDQLQAEQK(ub)GLTEVTQSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CDQLQAEQKGLTEVTQSLK 19 1 B8ZZD4;Q86VP1-3;Q86VP1-4;Q86VP1-2;Q86VP1 B8ZZD4 TAX1BP1 Tax1-binding protein 1 1 21912200.0 4024200.0 10672000.0 7216000.0 True False 5209406.228841171 10078093.818558056 5902762.042412525 1.0 1.9345954943505954 1.1330968987852559 22.312687511976893 -10.22260241849621 4.5611400380443445 0.9998542626022602 1.5338461964723997 0.3716677409309126 0.3272104314840365 230531563.32874376 100.095344761389 367799.9543295502 0.11201283397880038 5.989596709110487e-11 10.22260241849621 0.5339919338701395 CDVDIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CDVDIR 6 0 P60709;A0A2R8Y793;P63261;Q562R1 P60709;P63261;Q562R1 ACTB;ACTG1;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Beta-actin-like protein 2 0 84172600.0 2642600.0 42287000.0 39243000.0 False True 3464474.190974802 35977944.43343496 35182510.805436864 1.0 10.384821029165128 10.155223813498099 21.72420497806882 -9.847012334193783 7.9300068734907985 0.9999999933337755 10.270022421331616 0.9995401320256417 0.09373267079133622 9.888371168081401e-09 4.09293098146374e-09 0.09075626824259199 0.030252089414197728 1.4222883928039925e-10 9.847012334193783 9.27002242799784 CDVDIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CDVDIR 6 0 P60709;A0A2R8Y793;P63261;Q562R1 P60709;P63261;Q562R1 ACTB;ACTG1;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Beta-actin-like protein 2 0 36627100.0 19087000.0 4748100.0 12792000.0 False True 18481093.632695556 6644041.091014393 9441391.448225897 1.0 0.35950475783858293 0.5108675728758172 24.139546796061957 -10.233745570440544 8.279474652824513 1.000000255694385 0.4351861653585588 0.9488901120559601 0.06179361047874878 2.916759068424716e-07 2.6920737465814598e-08 0.05983143370840816 0.019943802023851848 5.837870132287517e-11 10.233745570440544 -0.5648140903358262 CDVDIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CDVDIR 6 0 P60709;A0A2R8Y793;P63261;Q562R1 P60709;P63261;Q562R1 ACTB;ACTG1;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Beta-actin-like protein 2 0 244112600.0 3878300.0 237980000.0 2254300.0 False True 5883664.641708906 195510609.65377343 1808736.6169052096 1.0 33.2293938488288 0.30741667430927255 22.488283587240566 -3.0459817184453994 6.09803759806882e-22 8.10603781089757 22.27709165968996 0.0 15.793475997664713 0.0 0.41363804238876667 15.378800019428695 15.378800307166939 0.0008995354465293574 3.0459817184453994 14.171053848792392 CDVDIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CDVDIR 6 0 P60709;A0A2R8Y793;P63261;Q562R1 P60709;P63261;Q562R1 ACTB;ACTG1;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Beta-actin-like protein 2 0 85654600.0 2642600.0 40038000.0 42974000.0 False True 3619640.633579791 38268988.7720395 32824426.277311742 1.0 10.572593427373432 9.068421315861041 21.78741503959171 -9.401515113188438 9.297891372739047 0.9999993153669445 9.820507371666723 0.9786548723630757 0.6140756930888149 0.0 0.0 0.5945762331607313 0.19819207772024372 3.967207230473541e-10 9.401515113188438 8.82050805629978 CDVDIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CDVDIR 6 0 P60709;A0A2R8Y793;P63261;Q562R1 P60709;P63261;Q562R1 ACTB;ACTG1;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Beta-actin-like protein 2 0 21049460.0 19087000.0 879160.0 1083300.0 False True 15871686.19747023 874423.7905804038 1309813.0213867263 1.0 0.0550933139491995 0.08252513344142956 23.919952071496233 -10.712833916234862 2.9718504526186256 1.130503551697916 0.06880922246810907 0.999349554383234 0.01119899717145837 10533649.695505114 9948059.786750825 10265160.605119538 0.004354441215882165 1.937162635925983e-11 10.712833916234862 -1.0616943292298069 CDVDIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CDVDIR 6 0 P60709;A0A2R8Y793;P63261;Q562R1 P60709;P63261;Q562R1 ACTB;ACTG1;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Beta-actin-like protein 2 0 12300400.0 3878300.0 4329000.0 4093100.0 False True 5020535.802722211 4088087.344503164 3348197.798752591 1.0 0.8142731184760281 0.6669004923612231 22.259409909333016 -6.973734069552712 0.1431866644121462 1.188603917865447 0.2887156518801194 0.9999988116869301 0.00014845442672660524 0.07510858386964152 0.004348770884714488 0.008059083222449788 0.018921995395453427 1.0623458616470415e-07 6.973734069552712 -0.8998882659853277 CEAVVAELK(ub)QEDQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CEAVVAELKQEDQR 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 78429500.0 22596600.0 38994900.0 16838000.0 True False 29624361.425785664 33177012.920929678 15095765.281501055 1.0 1.1199233105511504 0.5095726812312446 24.820280720238248 -6.855690602137182 1.207275714433469 1.0644587052156216 0.4823528052739105 0.9481896698215599 0.06009924631838209 0.15130618245217706 0.4215227097423304 0.038888367607528174 0.09038331728228616 1.394149662241021e-07 6.855690602137182 -0.582105899941711 CEAVVAELK(ub)QEDQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CEAVVAELKQEDQR 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 51191600.0 27296000.0 17465000.0 6430600.0 True False 26429503.42107497 24438865.57877179 4746232.946135191 1.0 0.9246812242141544 0.17958085971265467 24.65564598292228 -6.926374001496693 0.7759892054820525 1.0129836366931404 0.039848534247769504 0.9957760257958265 0.024064980242913064 0.09456532864625469 0.08723146001265093 0.02146847816293917 0.06881213339452974 1.1847480389382108e-07 6.926374001496693 -0.9731351024453709 down CEAVVAELK(ub)QEDQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CEAVVAELKQEDQR 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 126843900.0 48838700.0 57079200.0 20926000.0 True False 74091878.48723103 46892970.79817484 16789966.92780837 1.0 0.6329029814820576 0.22661008562094898 26.142812075725917 -7.4761953212349015 0.36043014844182586 1.0523972397289438 4.854889141478451e-14 0.9993713725560903 0.007919636867559279 0.11950511179439512 0.03918501962230069 0.01890202227867311 0.06411762651906597 3.3404477168461746e-08 7.4761953212349015 -1.0523972397288952 down CEAVVAELK(ub)QEDQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CEAVVAELKQEDQR 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 55095700.0 22596600.0 20099100.0 12400000.0 True False 30951173.67015405 19211055.303164452 9471375.386016307 1.0 0.620689073309343 0.3060102174784239 24.88349078176114 -7.68355021981474 0.25288348926448956 1.144367282697947 6.740406830277904e-10 0.999770858155874 0.00429493066963069 0.1283878510156871 0.0327798355895999 0.03894421153316695 0.07849602813999784 2.0722864160652136e-08 7.68355021981474 -1.1443672820239064 down CEAVVAELK(ub)QEDQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CEAVVAELKQEDQR 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 50636900.0 27296000.0 13811000.0 9529900.0 True False 22697833.417831372 13736597.401731133 11522558.028720912 1.0 0.6051942116616157 0.507650127508153 24.436051258356557 -13.999999999968871 0.19635296720356568 3.1649273950377474 0.44197451464891746 0.9994871500862856 0.004820526213378769 12.46116048528738 0.14051747545511073 10.345498753726247 0.06384352527850815 1.0000000000716768e-14 13.999999999968871 -2.72295288038883 CEAVVAELK(ub)QEDQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CEAVVAELKQEDQR 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 125677000.0 48838700.0 61714300.0 15124000.0 True False 63222659.90470277 58279844.953770295 12371587.18534465 1.0 0.9218189339331355 0.19568280113479375 25.913938397818367 -6.927430642166356 0.767594602850534 1.0121586663179414 0.05591995647414593 0.9960085815952487 0.02287919777069375 0.09399432257516824 0.08437993913915759 0.020533816813916736 0.0666553091243274 1.1818690446949855e-07 6.927430642166356 -0.9562387098437954 down CEFAVGYQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CEFAVGYQR 9 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;A0A6I8PRS0;Q9P2J5-2;A0A6I8PLB3;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 11163800.0 3892700.0 2514900.0 4756200.0 False True 5103367.396960425 2139686.72300342 4264074.048691967 1.0 0.41926958350633764 0.8355412646229736 22.2830180759679 -9.858417418028417 5.856073848463396 1.000000033648998 0.6274054240728945 0.5164909212971255 0.1699422021863781 1.706177018685895e-07 3.3286471235683264e-08 0.16454586404729837 0.05484860990684685 1.3854236019710454e-10 9.858417418028417 -0.3725946095761036 CEFFNAGGSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CEFFNAGGSVK 11 0 P0DN79;P35520;P35520-2;C9JMA6 P0DN79 CBS Cystathionine beta-synthase 0 7655300.0 1851900.0 2987500.0 2815900.0 False True 2427858.8338251095 2541776.645183791 2524537.680020124 1.0 1.0469211017426425 1.039820620889517 21.211253108849743 -10.01061410242492 6.1981452863520925 0.9999999680227949 1.0433708613160815 0.9802939875671656 0.0028987591697659195 1.2826145834706643e-09 2.0243146765064134e-10 0.0028067135466304013 0.0009355704990965529 9.758563614754354e-11 10.01061410242492 0.04337089329328658 CEFFNAGGSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CEFFNAGGSVK 11 0 P0DN79;P35520;P35520-2;C9JMA6 P0DN79 CBS Cystathionine beta-synthase 0 6978100.0 1851900.0 2471900.0 2654300.0 False True 2536597.47571574 2362683.2845198135 2027409.0070244432 1.0 0.9314380019451631 0.7992631966379997 21.274463170372634 -6.960757404253569 0.42462468164767175 1.005559532171132 0.7201176798458652 0.9997972615758168 0.0011862170112788483 0.0794316717920942 0.020139783225721377 0.001715441389760059 0.01098900048513782 1.094567618104536e-07 6.960757404253569 -0.28544185232526675 CEFQDAYVLLSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CEFQDAYVLLSEK 13 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 78968000.0 31955000.0 14151000.0 32862000.0 False True 30940606.01628267 19801568.096490122 24254456.36113188 1.0 0.6399864335581997 0.7839037266551222 24.88299811853318 -10.069641289120783 5.014928093090849 1.0000062200411572 0.7119450809686437 0.8423086419261173 0.058753988879917875 4.086084751152946e-06 7.579887373624112e-07 0.05688953314838046 0.018962768370561607 8.51841336562747e-11 10.069641289120783 -0.2880611390725135 CEFQDAYVLLSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CEFQDAYVLLSEK 13 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 269397000.0 12428000.0 223020000.0 33949000.0 False True 18854184.60850326 183220338.53678697 27238965.269624684 1.0 9.717754564371582 1.44471722512677 24.168381423457724 -6.633871871505901 2.066496048798847 6.727145874463109 1.4784661214886454 0.13159226290208148 3.735812246493786 0.5489603983157083 4.472461534027596 1.4760534774390623 4.137494270729611 2.323422166965993e-07 6.633871871505901 -5.248679752974464 CEFQDAYVLLSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CEFQDAYVLLSEK 13 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 78878000.0 10844000.0 30344000.0 37690000.0 False True 14853319.848081158 29003301.745810598 28788398.249915745 1.0 1.9526477610698876 1.938179379718589 23.824282086353563 -10.264785089205727 5.398153429197294 0.9998984174899208 1.9454135703943036 0.9998243769034794 0.0059066919526765405 7.221980477709959e-06 9.836096279542102e-07 0.005719735120921658 0.0019063766302912502 5.435192256572048e-11 10.264785089205727 0.9455151529043828 CEFQDAYVLLSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CEFQDAYVLLSEK 13 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 56070900.0 31955000.0 9317900.0 14798000.0 False True 26571998.346527055 9267702.623241661 17892193.381778594 1.0 0.34877702844855646 0.6733476778240539 24.663403393967457 -10.575108715032517 6.528199827997441 1.0008231486392665 0.5110623531364683 0.7515965708241092 0.13250541274229272 0.0015899043997958922 0.00010347950081401092 0.1284940741965076 0.04276593806943665 2.6600590955239405e-11 10.575108715032517 -0.48976079550279816 CEFQDAYVLLSEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CEFQDAYVLLSEK 13 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 95834000.0 12428000.0 48823000.0 34583000.0 False True 16088290.992504852 46105957.13113376 28289248.851545516 1.0 2.8658082547495827 1.7583750110390717 23.939507745550173 -10.625589373829053 6.198342090303237 0.9937304118004682 2.3120916328943255 0.6517719713481535 0.4521077285476667 0.03904388707039194 0.0023584420835126075 0.43633726412749946 0.14591714194639807 2.3681577364499268e-11 10.625589373829053 1.3183612210938573 CEGINISGNFYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CEGINISGNFYR 12 0 P40429;M0QYS1 P40429 RPL13A 60S ribosomal protein L13a 0 43754000.0 13180000.0 15006000.0 15568000.0 False True 17279107.635301568 12767163.29292987 13957172.698800843 1.0 0.7388786251233423 0.8077484667255649 24.042525376888374 -10.025945529444089 5.581368093901251 1.0000008296004816 0.7733135459243246 0.9352560993543289 0.028115995099080214 2.9024727766589243e-07 5.065875437322894e-08 0.02722329498378814 0.009074398398332698 9.420077386352413e-11 10.025945529444089 -0.2266872836761571 CEGINISGNFYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CEGINISGNFYR 12 0 P40429;M0QYS1 P40429 RPL13A 60S ribosomal protein L13a 0 15811000.0 6481700.0 3035800.0 6293500.0 False True 6275941.9814032065 4248010.771487862 4645043.549047031 1.0 0.6768722183977345 0.7401348774114176 22.581400584547843 -10.751718048681024 6.944130438704336 1.0055021321029172 0.7085035479046082 0.9658797136477127 0.025826872392534426 0.0022243302961150674 7.952907761603878e-05 0.025283323584470323 0.008335587221742501 1.7712585160909182e-11 10.751718048681024 -0.29699858419830893 CEGINISGNFYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CEGINISGNFYR 12 0 P40429;M0QYS1 P40429 RPL13A 60S ribosomal protein L13a 0 80603000.0 15924000.0 39439000.0 25240000.0 False True 24157872.200338416 32400802.31168658 20251302.936915003 1.0 1.3412109329410515 0.8382900103524561 24.525990053427233 -6.724019026472218 1.7450100030657636 1.206698488878394 0.8389009943173604 0.531295590952101 0.14351720434511728 0.34759039940084985 2.070622591601982 0.06525181108247766 0.1630275654076434 1.8879086378724769e-07 6.724019026472218 -0.3677974945610336 CEGINISGNFYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CEGINISGNFYR 12 0 P40429;M0QYS1 P40429 RPL13A 60S ribosomal protein L13a 0 39215000.0 13180000.0 13905000.0 12130000.0 False True 18053002.176107503 13290631.12231403 9265143.825191772 1.0 0.7362006049001479 0.5132190056152464 24.105735438411266 -6.9730704979055895 0.1694840244230129 1.1983830114036924 0.04506806049965318 0.9999974952014469 0.00031483261736562604 0.07531838326403348 0.005283696115280131 0.009441745002864937 0.025879098819738194 1.0639702926461707e-07 6.9730704979055895 -1.1533149509040392 CEGINISGNFYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CEGINISGNFYR 12 0 P40429;M0QYS1 P40429 RPL13A 60S ribosomal protein L13a 0 57837000.0 15924000.0 27673000.0 14240000.0 False True 20613931.908967428 26132973.22347797 11648466.114738693 1.0 1.2677335570372026 0.5650773547802107 24.297116375519682 -6.803448608245648 1.4417775458230753 1.1470856830798246 0.5545322450552818 0.842031625110549 0.11508323543406301 0.21588931940413988 0.88559307780984 0.06278334624210813 0.1457160527979887 1.572357844670841e-07 6.803448608245648 -0.5925534380245429 CEK(ub)CDTEFPNFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CEKCDTEFPNFK 12 1 P27694 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 8224800.0 1930300.0 1977600.0 4316900.0 True False 2530641.993051789 1682549.7886244224 3870228.5986288083 1.0 0.6648707297373886 1.5293465489211953 21.271071994836372 -6.801586903234699 1.449442339315901 0.8154658768196751 1.5417507645330215 0.8367617881508949 0.14378420957933044 0.21849768986948956 0.9060849505282966 0.07803444256965558 0.18130533780381425 1.5791125923875186e-07 6.801586903234699 0.7262848877133464 CEK(ub)CDTEFPNFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CEKCDTEFPNFK 12 1 P27694 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 18182200.0 4125300.0 4834500.0 9222400.0 True False 6258381.699827691 3971745.702879093 7399588.597678492 1.0 0.6346282303280488 1.1823485611116085 22.57735822081692 -6.726900490521648 1.7343566919258475 0.779362938478426 1.1818514083962508 0.5448595925426428 0.15363540883292717 0.34210809802800146 2.014517213907728 0.07023795074879183 0.17491727792619885 1.8754241729842803e-07 6.726900490521648 0.40248846991782483 CEK(ub)GTTAVLTEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CEKGTTAVLTEK 12 1 Q99436 Q99436 PSMB7 Proteasome subunit beta type-7 1 12030980.0 2596880.0 2660500.0 6773600.0 True False 2514443.4658602444 3722851.524324218 4999390.956355757 1.0 1.4805866884147867 1.9882693821653927 21.26180768589857 -6.970431228249655 0.24767086071544447 0.8341979237438586 2.6494836279171152 0.9999855530027356 0.0015336979550504598 0.07616303048501614 0.00852803755148498 0.01150429734966799 0.048843947303194246 1.0704558791843384e-07 6.970431228249655 1.8152857041732566 CEK(ub)GTTAVLTEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CEKGTTAVLTEK 12 1 Q99436 Q99436 PSMB7 Proteasome subunit beta type-7 1 11597480.0 2596880.0 2413600.0 6587000.0 True False 2159420.781290225 2400597.457737912 7964311.245153103 1.0 1.1116858180384774 3.6881701399550915 21.042212961332847 -6.915992159577901 0.8539301034619599 0.9345327239183606 4.06761613091849 0.9929930248417318 0.10394219611086082 0.10058787412646181 0.11826102481904031 0.08770531669094457 0.25344234529575826 1.2134107562616866e-07 6.915992159577901 3.1330834070001297 up CELLYEGPPDDEAAMGIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CELLYEGPPDDEAAMGIK 18 0 P13639 P13639 EEF2 Elongation factor 2 0 23331300.0 1854300.0 10397000.0 11080000.0 False True 2431005.2570667462 8845808.127188578 9933547.886864943 1.0 3.6387449601248254 4.086189389343721 21.213121582532825 -9.891381898849113 0.4413892218816382 2.1295054011838785e-23 4.10758523256151 0.9988844048995885 0.04548109235119836 1.196228913032373 0.196350621136754 1.7564429838797906 0.10223591274805988 1.2841569339983811e-10 9.891381898849113 4.10758523256151 CELLYEGPPDDEAAMGIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CELLYEGPPDDEAAMGIK 18 0 P13639 P13639 EEF2 Elongation factor 2 0 20493100.0 1854300.0 10110000.0 8528800.0 False True 2539884.820573305 9663306.770700818 6514473.096149676 1.0 3.8046240098870343 2.564869494625045 21.276331644055716 -9.713675756321505 6.888020045106452 0.9999999971369913 3.1847467522564283 0.8054724393372544 0.5061276614519635 2.2552956249943683e-08 4.240640042070052e-09 0.4900560009639663 0.1633520003213224 1.933411260557561e-10 9.713675756321505 2.184746755119437 CELLYEGPPDDEAAMGIK(ub)SCDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CELLYEGPPDDEAAMGIKSCDPK 23 1 P13639 P13639 EEF2 Elongation factor 2 1 9763900.0 2774000.0 2838700.0 4151200.0 True False 3636740.863454213 2415177.025165934 3721673.645122178 1.0 0.6641047893833092 1.023354092264714 21.794214699316562 -10.118907705020574 13.009264972923424 1.0000003395756314 0.8437294408240116 0.20146335088377876 0.14666291375179907 0.0 0.0 0.14200575561668394 0.04733525187222797 7.604878764035815e-11 10.118907705020574 -0.1562708987516198 CELLYEGPPDDEAAMGIK(ub)SCDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CELLYEGPPDDEAAMGIKSCDPK 23 1 P13639 P13639 EEF2 Elongation factor 2 1 12051300.0 2774000.0 2731900.0 6545400.0 True False 3799622.764531274 2611195.6248147893 4999511.326744447 1.0 0.6872249659070852 1.3157914973596578 21.857424760839454 -6.7713939126573734 1.5689592403137937 0.820920176805819 1.3195280809139962 0.7359159840756763 0.13187071235878242 0.2641833876352281 1.2835997419705623 0.06624019319506193 0.1574886003686732 1.6928017032978817e-07 6.7713939126573734 0.49860790410817724 CENK(ub)HIANYISGIQTIGHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CENKHIANYISGIQTIGHR 19 1 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 1 10545500.0 3118100.0 4055700.0 3371700.0 True False 4087859.2957233503 3450605.3689947785 3022828.827630188 1.0 0.844110601508409 0.7394649886292859 21.96291410883463 -7.940728464138256 0.054289675298583 1.6821250783969899 8.149088576555108e-05 0.9999992444571376 9.286768680376668e-05 0.11820270607564742 0.008286548489228916 0.1213061536164281 0.13183837361619696 1.1462293795211706e-08 7.940728464138256 -1.6820435875112243 CESAFLSK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 CESAFLSKR 9 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 36791500.0 4507100.0 4850400.0 27434000.0 True False 5908851.746818491 4126739.2267111186 24595392.845510155 1.0 0.6983995205046535 4.162465720815059 22.494446371449524 -6.8857004771340105 1.0475188839396274 0.7942372996485676 4.436432600878685 0.9779991887354659 0.23238853347847166 0.12269940163499436 0.24280023766614664 0.16992230265273037 0.41755187887286743 1.3010665842261138e-07 6.8857004771340105 3.642195301230118 up CESAFLSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 CESAFLSKR 9 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 29411700.0 6636800.0 6505900.0 16269000.0 True False 6426118.416800652 9103739.797820294 12007660.840461772 1.0 1.4166778772733448 1.8685713616899053 22.615516135529855 -6.9700878872839604 0.256078206870647 0.8668988618147286 2.4316892716211536 0.9999830599685596 0.0014598308686456594 0.07627421167123899 0.008928048218030171 0.009677796195121102 0.04289263102312922 1.0713024860118864e-07 6.9700878872839604 1.564790409806425 CESAFLSK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CESAFLSKR 9 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 31037000.0 4507100.0 4097900.0 22432000.0 True False 6173496.669797734 3916841.2280568588 17134023.60154178 1.0 0.6344607339336571 2.775416351217235 22.557656432972415 -6.8629248235829845 1.1707879179017346 0.7998961017691218 2.8850759687782497 0.9571021412730463 0.19367239591184637 0.14382375651172002 0.37295477038352937 0.12885261096767697 0.30185798404342307 1.3711190864712695e-07 6.8629248235829845 2.0851798670091277 up CESAFLSK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CESAFLSKR 9 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 33993100.0 6636800.0 5742300.0 21614000.0 True False 5518793.2600917155 5711365.090142686 26133387.46815532 1.0 1.0348938293165506 4.73534452851039 22.39592141096413 -6.908962374309292 0.9027553896112778 0.8816325946116232 5.2031279819097165 0.9905244613754521 0.17061117217312974 0.10510863283065665 0.1425124849071577 0.13896892307969363 0.3809224248560688 1.2332116695643119e-07 6.908962374309292 4.321495387298093 up CESCSQK(ub)LER ddPTM_RPMI8226_Bortezomib_1h_R1 1 CESCSQKLER 10 1 Q8TCJ0-2;Q8TCJ0;E5RFH9 Q8TCJ0-2 FBXO25 F-box only protein 25 1 2799550.0 474240.0 728610.0 1596700.0 True False 621733.2325466926 619904.2280995352 1431488.8006279087 1.0 0.9970582166893901 2.302416415420424 19.245936169524068 -6.906390417969346 0.9199691950960516 0.9548264788913337 2.4587069861786643 0.9894865332677938 0.06302423754117802 0.10685349530748284 0.15207458715455144 0.05069504712827823 0.13667638899178966 1.240536600246302e-07 6.906390417969346 1.5038805072873307 up CFAASGLEFDCYGGGLSK(ub)INTPLLTPLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CFAASGLEFDCYGGGLSKINTPLLTPLK 28 1 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 42554000.0 10046000.0 11538000.0 20970000.0 True False 15240516.460977124 9478953.753194528 16825270.308522496 1.0 0.621957515512358 1.1039829491082593 23.861408457007713 -6.697506099217733 1.8395835933075417 0.7646826567149481 1.1024925485520871 0.40583601105590295 0.15965000092151987 0.4007310435510562 2.6346346180707845 0.06927958570801905 0.17873125114896043 2.0067529070470164e-07 6.697506099217733 0.33780989183713905 CFAASGLEFDCYGGGLSK(ub)INTPLLTPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CFAASGLEFDCYGGGLSKINTPLLTPLK 28 1 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 29502600.0 10046000.0 8535600.0 10921000.0 True False 13004745.036265183 8060586.356604573 8933490.058922848 1.0 0.6198188687380436 0.6869408076829506 23.632534779100162 -10.71013074010105 6.808888277934406 1.0036827006121234 0.6533798382105043 0.9726449835983484 0.027402416826878086 0.0015430425432459774 6.569063887892823e-05 0.026725082492780848 0.008844092001361057 1.9492577064783535e-11 10.71013074010105 -0.3503028624016191 CFFDIAINNQPAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CFFDIAINNQPAGR 14 0 C9JN15;Q13427-2;Q13427;E9PG73;C9JT64;C9J679 C9JN15 PPIG Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase G 0 6986500.0 2253000.0 2180800.0 2552700.0 False True 3085994.985035674 2084445.045058788 1949804.834506762 1.0 0.6754531537369598 0.6318237210240386 21.55730428675128 -13.999999999999998 0.2827975510564099 3.686241140670466 0.6190475239733942 0.9996113834928255 0.003237816604128205 15.551592652464647 0.16850291720756264 24.2011641172556 0.017032515880820394 1.0000000000000041e-14 13.999999999999998 -3.0671936166970717 CFFLSK(ub)IEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CFFLSKIEEK 10 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 6223300.0 1881400.0 2699200.0 1642700.0 True False 2577004.4229232627 2579940.4189392333 1254728.0924684685 1.0 1.0011393057729563 0.4868940391825751 21.29726358262725 -6.9063992309024815 0.9199141722987576 1.017791374065823 0.42531277758836 0.9894901333873722 0.02482458992695229 0.10684734183231759 0.15204253428042858 0.019969102128745895 0.05384041119231922 1.240511426877449e-07 6.9063992309024815 -0.592478596477463 down CFFLSK(ub)IEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CFFLSKIEEK 10 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 2998700.0 790290.0 607910.0 1600500.0 True False 657161.1507831905 604635.0681693134 1935157.1501241133 1.0 0.9200712297869743 2.944722383266014 19.325887669835762 -6.897706085085917 0.9756274658406608 0.9104428336274771 3.147635448478773 0.9853909481390105 0.1131516038077817 0.11311455608614882 0.1870828509791505 0.08734359840336386 0.22475406624656105 1.265592565322873e-07 6.897706085085917 2.237192614851296 up CFIVGADNVGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CFIVGADNVGSK 12 0 P05388;F8VWS0;P05388-2;F8VU65;G3V210;F8VZS0;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 23900900.0 6266900.0 17634000.0 0.0 False True 8215966.588745921 15003075.93679363 0.0 1.0 1.8260877493519223 0.0 22.969998884092675 -6.7929527434046 1.5452459051503573 1.4650033349490434 2.8087918332488436e-21 0.7799436285272323 0.35024224200776694 0.23886441909980338 1.1362248865297753 0.1800653613776039 0.41002727671390304 1.6108209028215114e-07 6.7929527434046 -1.4650033349490434 CFIVGADNVGSK(ub)QMQQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CFIVGADNVGSKQMQQIR 18 1 P05388;F8VWS0;P05388-2;F8VU65;G3V210;F8VZS0;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 54315000.0 14148000.0 20527000.0 19640000.0 True False 18548165.009426888 17464451.61361932 17607841.200182952 1.0 0.9415730130038856 0.9493036745809611 24.144773130693878 -10.103727089007752 4.622114806429497 1.000003928358868 0.9454383437911918 0.9851669390636522 0.0031560293772047165 760654.4994540098 1662755.214270476 18.322140541911224 0.0010803928380111166 7.875405253150242e-11 10.103727089007752 -0.05456558456767613 CFIVGADNVGSK(ub)QMQQIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CFIVGADNVGSKQMQQIR 18 1 P05388;F8VWS0;P05388-2;F8VU65;G3V210;F8VZS0;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 42175700.0 20006000.0 12229000.0 9940700.0 True False 19370920.480730757 17112103.473392505 7336932.455392363 1.0 0.8833913437626667 0.37876013495026134 24.207389174757413 -6.943071470062721 0.6303509674998242 1.0055047704557414 0.22943390828692892 0.9985390567911323 0.01030497710166349 0.08639317233540351 0.04843731492924993 0.010282027429431994 0.042879727845573416 1.1400621567667335e-07 6.943071470062721 -0.7760708621688125 down CFIVGADNVGSK(ub)QMQQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CFIVGADNVGSKQMQQIR 18 1 P05388;F8VWS0;P05388-2;F8VU65;G3V210;F8VZS0;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 124459000.0 37896000.0 28803000.0 57760000.0 True False 57491002.568702914 23662879.611133832 46343710.68289268 1.0 0.41159274588847555 0.8061037138378481 25.776832853917277 -10.086339378494605 5.758734316955997 1.00000214198549 0.608848229863152 0.5672351595109993 0.16105842823472954 4.42932999689972e-06 7.02531329657049e-07 0.15594500759355345 0.05198138419326498 8.197107327819704e-11 10.086339378494605 -0.3911539121223381 CFIVGADNVGSK(ub)QMQQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CFIVGADNVGSKQMQQIR 18 1 P05388;F8VWS0;P05388-2;F8VU65;G3V210;F8VZS0;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 56404000.0 14148000.0 23865000.0 18391000.0 True False 19378897.93532388 22810565.388998505 14047424.574534371 1.0 1.1770826940276815 0.7248825305451817 24.20798319221677 -6.800490500523663 1.4538443051999503 1.0976469016613655 0.7185610133932693 0.8335854733395779 0.07589729774222921 0.22007460523204875 0.9182864723532838 0.041067203281787035 0.09548154691190736 1.583104194123976e-07 6.800490500523663 -0.3790858882680962 CFIVGADNVGSK(ub)QMQQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CFIVGADNVGSKQMQQIR 18 1 P05388;F8VWS0;P05388-2;F8VU65;G3V210;F8VZS0;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 45312000.0 20006000.0 12963000.0 12343000.0 True False 16635875.416073242 12893165.74604597 14923864.2324161 1.0 0.7750217781499408 0.8970892038537971 23.98779445019169 -10.11451633722086 4.629779859571614 1.0000130347420493 0.8360554909986916 0.7063227594745722 0.04983381787578597 12035318.768295532 26293135.36015922 973.6179869527313 0.017059443950222332 7.682165564872696e-11 10.11451633722086 -0.1639575437433577 CFIVGADNVGSK(ub)QMQQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CFIVGADNVGSKQMQQIR 18 1 P05388;F8VWS0;P05388-2;F8VU65;G3V210;F8VZS0;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 108948000.0 37896000.0 31120000.0 39932000.0 True False 49057119.04183812 29388144.643321402 32664785.736920327 1.0 0.5990597331705898 0.6658521000603873 25.547959176009726 -10.674895907672903 6.694046704478825 1.0024493308806597 0.6324559166154978 0.9758303479383271 0.027267869598794958 0.0010019703095997619 4.866174370000763e-05 0.026540093122918742 0.008800667070224037 2.1139956646464074e-11 10.674895907672903 -0.36999341426516186 CFLSWLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CFLSWLVK 8 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 14196600.0 3627600.0 4462200.0 6106800.0 False True 4755818.729728368 3796457.1535193673 5474926.916561983 1.0 0.7982762525804268 1.1512059705594975 22.18126229645446 -6.75168079210561 1.6436478497021547 0.8816250269159789 1.1519975743636965 0.656173688834116 0.08477350298435797 0.2971169706089954 1.5797869600567294 0.04073475449606143 0.09871817803637412 1.7714104725625772e-07 6.75168079210561 0.27037254744771766 CFLSWLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CFLSWLVK 8 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 25034600.0 3627600.0 10275000.0 11132000.0 False True 4968821.752203907 9821016.525118781 8502850.87073658 1.0 1.9765282424878086 1.7112408725398862 22.24447235797735 -10.115319620543408 5.470494199607187 0.9999877920133164 1.84388455751411 0.9309957215814805 0.10830311526381704 1.6125669555228253e-05 2.6079753655964846e-06 0.10486555676130659 0.034954680146461664 7.667969547500733e-11 10.115319620543408 0.8438967655007936 CFLSWLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CFLSWLVK 8 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 22530420.0 19651000.0 597920.0 2281500.0 False True 16340677.186906684 594698.8862821722 2758551.101535877 1.0 0.03639377239265747 0.1688149805533289 23.961964436798436 -10.146550068141666 5.215003269217119 1.0000315513943387 0.10260437647233954 0.9839315730589083 0.054060731855265935 604870065.8391477 6.606787996672754 230871.99739193436 0.01850642644484238 7.1359193310878e-11 10.146550068141666 -0.8974271749219992 CFLSWLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CFLSWLVK 8 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 10503000.0 2964100.0 3985300.0 3553600.0 False True 3837085.8811460943 3763514.5516397427 2906881.2630151296 1.0 0.9808262489333763 0.7575752414868746 21.871579624834858 -6.923833140815237 0.7957783646111225 1.0042791938917683 0.7181958963019455 0.9951811944657591 0.007638684150069867 0.09596859748560432 0.09430869486478542 0.00671883881786014 0.020926914598256036 1.1916997800412643e-07 6.923833140815237 -0.28608329758982287 CFTCGK(ub)IVGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CFTCGKIVGNK 11 1 P62875 P62875 POLR2L DNA-directed RNA polymerases I, II, and III subunit RPABC5 1 17361300.0 7327600.0 5993800.0 4039900.0 True False 9606554.560579333 5099548.403649414 3621889.9014571914 1.0 0.5308405184701184 0.37702277945931634 23.195587663211235 -13.999999999999998 0.155902897116642 3.291674345303661 0.21876217365815223 0.9995477483589655 0.005634856372744936 11.984843101668451 0.12462549605316298 8.309226952734548 0.14353494077013146 1.0000000000000041e-14 13.999999999999998 -3.072912171645509 CFTCGK(ub)IVGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CFTCGKIVGNK 11 1 P62875 P62875 POLR2L DNA-directed RNA polymerases I, II, and III subunit RPABC5 1 15445600.0 7327600.0 5830300.0 2287700.0 True False 10036811.740944248 5572698.067776158 1747392.3766604466 1.0 0.5552259234915058 0.17409835132526405 23.258797724734126 -7.871128658187706 0.35411833657428826 1.0764368223091862 1.2072824559585066e-12 0.9986568507992682 0.012369274376492408 0.10960146494281746 0.0644605748473853 0.04147867568213955 0.08249038989909208 1.3454617067892008e-08 7.871128658187706 -1.076436822307979 down CFTCGK(ub)IVGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CFTCGKIVGNK 11 1 P62875 P62875 POLR2L DNA-directed RNA polymerases I, II, and III subunit RPABC5 1 4320450.0 2723000.0 1174400.0 423050.0 True False 2264295.1493535647 1168073.274099851 511507.79903780454 1.0 0.51586617337997 0.2259015566870049 21.110630594082064 -8.593370550340223 0.24453241935982495 1.257112110130258 3.1344376831629924e-11 0.9993594856720777 0.008081498058059225 0.20642861227022533 0.06756113706120724 0.15252661835647 0.1131543019159553 2.5505242063444895e-09 8.593370550340223 -1.2571121100989135 down CFTFTASFNRPNLYYEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CFTFTASFNRPNLYYEVR 18 1 P46063 P46063 RECQL ATP-dependent DNA helicase Q1 0 215513000.0 64215000.0 60175000.0 91123000.0 False True 97418849.74533613 49436301.10057907 73112499.10937035 1.0 0.5074613509583734 0.7504964316504935 26.537697613141322 -10.107235804102327 5.269698622574876 1.0000073248766306 0.6289788913040938 0.7565373550191041 0.0992186562164958 8.538726549123905e-06 1.446333702959978e-06 0.09606994680560371 0.03202268359645891 7.812035279215128e-11 10.107235804102327 -0.3710284335725368 CFTFTASFNRPNLYYEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CFTFTASFNRPNLYYEVR 18 1 P46063 P46063 RECQL ATP-dependent DNA helicase Q1 0 145238000.0 64215000.0 42635000.0 38388000.0 False True 83127583.36688925 40262324.77082292 31401777.89414244 1.0 0.4843437417532326 0.37775400922637864 26.30882393523377 -13.999999999999998 0.22159120803433444 4.133575855280316 0.32160101487787246 0.9994995368432118 0.006078503620465067 13.043377060529659 0.14911290888499237 17.90023253591298 0.05837634754240252 1.0000000000000041e-14 13.999999999999998 -3.811974840402444 CGCVLVESECVCK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 CGCVLVESECVCKR 14 1 H7C0T2;Q6GPH6-3;Q6GPH6;Q6GPH6-2 H7C0T2 ITPRIPL1 Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 1 8151880.0 789380.0 2952800.0 4409700.0 True False 1197547.171408135 2425849.769668298 3538120.862159828 1.0 2.025682017031416 2.9544730651399154 20.191651054192725 -6.972305902756411 0.19541039180018777 0.4133363099807667 4.592336711206468 0.9999952255416411 0.0017441810062260037 0.07556132553055953 0.0062743314538096446 0.03132534356367859 0.09977839090680733 1.0658451105095529e-07 6.972305902756411 4.179000401225702 CGEALGLK(ub)QAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CGEALGLKQAVK 12 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 1 12934900.0 2725300.0 2941400.0 7268200.0 True False 4134479.3461179603 2416484.188736906 5831637.084234775 1.0 0.5844712203014985 1.410488865958503 21.97927423195715 -6.769958223621571 1.5747654485062847 0.7616452036379174 1.4151090829145807 0.7303206450924087 0.1751218129186821 0.26651111987070963 1.304359977220959 0.0876574176367598 0.2086561042039582 1.6984070206021567e-07 6.769958223621571 0.6534638792766633 CGEALGLK(ub)QAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CGEALGLKQAVK 12 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 1 3722700.0 1100000.0 1017800.0 1604900.0 True False 1506699.726382264 972830.2305854869 1225855.6739530328 1.0 0.6456696138927092 0.8136031702192144 20.522960496927872 -10.05950970741177 4.827985738224744 1.000007785284185 0.729636392052312 0.7755780708573895 0.06855858729439032 17797620.975528974 37082823.765244514 915.1356193154111 0.02346942657989879 8.719474111772201e-11 10.05950970741177 -0.2703713932318731 CGEALGLK(ub)QAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CGEALGLKQAVK 12 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 1 13495300.0 2725300.0 0.0 10770000.0 True False 3527954.5736943623 0.0 8809970.509531997 1.0 0.0 2.497189327556016 21.750400554049598 -6.798027641094476 1.4639728668592529 0.4468686918369322 2.5299980009002025 0.826328852530183 0.427651673289996 0.22358468518362454 0.9462352533881996 0.22983129767692484 0.5351529872985085 1.592107392603757e-07 6.798027641094476 2.0831293090632705 CGEMAQAASAAVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CGEMAQAASAAVTR 14 0 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 6301110.0 813010.0 3153100.0 2335000.0 False True 1065863.9832000388 2682669.7706875326 2093396.5989015908 1.0 2.5168969145888247 1.9640372804573012 20.02359191428531 -9.854260682927999 5.760999114144508 0.9999996888976823 2.2404670975260346 0.8703391021420095 0.22570400051119363 9.021605412515171e-07 1.797523335321857e-07 0.21853701413932616 0.07284565292781929 1.398747479887159e-10 9.854260682927999 1.2404674086283523 CGIFAYLNYHVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CGIFAYLNYHVPR 13 0 Q06210-2;Q06210;A0A6I8PTT9;A0A6I8PRT6 Q06210-2 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 0 11603100.0 2991400.0 4259900.0 4351800.0 False True 3921754.3687588056 3624339.5249601468 3901517.481413251 1.0 0.9241628067867016 0.9948398381329631 21.90306774736546 -10.256541193559158 5.238923094525078 1.0000051584078264 0.9595013226171623 0.30448714652696585 0.028853777222197032 1.7386836039729839e-06 2.467168087076875e-07 0.027941107938254453 0.009312516554725406 5.5393499978397635e-11 10.256541193559158 -0.04050383579066419 CGIFAYLNYHVPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CGIFAYLNYHVPR 13 0 Q06210-2;Q06210;A0A6I8PTT9;A0A6I8PRT6 Q06210-2 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 0 31774800.0 8804800.0 9180000.0 13790000.0 False True 13357525.31710248 7541757.2763326205 11064400.455628287 1.0 0.5646073727950516 0.8283271184567278 23.671149415777883 -10.284551026211828 5.969970936076545 1.0000162553372076 0.6964672456258891 0.6385063589418234 0.10766313532794694 2.3294808044601822e-05 2.7918112402401857e-06 0.10424995948374272 0.03474812751046738 5.19336651919272e-11 10.284551026211828 -0.3035490097113185 CGIFAYLNYHVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CGIFAYLNYHVPR 13 0 Q06210-2;Q06210;A0A6I8PTT9;A0A6I8PRT6 Q06210-2 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 0 17213300.0 2991400.0 5824100.0 8397800.0 False True 4097401.419545366 5566772.004276807 6414412.598119986 1.0 1.3586103567305539 1.5654830809405313 21.96627780888835 -10.46873044054501 0.09872447759253346 3.042539788416779e-17 2.129185959575951 0.9999150755217097 0.0021528264727123316 2.363835533651319 0.05324267274543134 0.8964537974472273 0.33348186542054487 3.398361378549223e-11 10.46873044054501 2.129185959575951 CGIFAYLNYHVPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CGIFAYLNYHVPR 13 0 Q06210-2;Q06210;A0A6I8PTT9;A0A6I8PRT6 Q06210-2 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 0 28253800.0 8804800.0 9536400.0 9912600.0 False True 11397987.168555425 9005690.956830671 8108608.511865087 1.0 0.7901123964830755 0.71140705740001 23.442275737870332 -13.999999999999998 0.13613065497091265 1.9997084227495316 0.6093103399655035 0.9996187991259937 0.0023782038376753646 11.932065081631086 0.11529977492987012 3.176304553471852 0.09105676771119217 1.0000000000000041e-14 13.999999999999998 -1.390398082784028 CGLVIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CGLVIGR 7 0 A0A087WTP3;Q92945;M0R3J3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 7019800.0 1788400.0 3473400.0 1758000.0 False True 2344609.718890233 2955182.259207155 1576099.0239267652 1.0 1.260415426668931 0.6722223367191259 21.160916362648237 -6.786351207657507 1.5108542359077837 1.1462399076949898 0.6665781609347564 0.7892907951618021 0.11046719515221987 0.24083630505022888 1.086079618523337 0.057563076618327595 0.13513762646091548 1.6354933866854597e-07 6.786351207657507 -0.47966174676023343 CGLVIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CGLVIGR 7 0 A0A087WTP3;Q92945;M0R3J3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 6517500.0 1788400.0 2290000.0 2439100.0 False True 2449619.809692762 2188820.2279826743 1863034.814841321 1.0 0.8935346698789157 0.7605403938478877 21.22412642417113 -6.968119312090813 0.299722451026617 1.0231418681510398 0.626767566919012 0.9999637693905581 0.000589603735229698 0.07691779786970424 0.011202759179199358 0.002209458989654706 0.011931174509442949 1.0761695210064725e-07 6.968119312090813 -0.39637430123202777 CGLVLSWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CGLVLSWK 8 0 P49756;P49756-2;P49756-3;E9PQU5;E9PSE8 P49756 RBM25 RNA-binding protein 25 0 43127000.0 11063000.0 12286000.0 19778000.0 False True 14503700.13424439 10452976.690452898 17731562.283972435 1.0 0.720711031922991 1.2225543909382686 23.789917666820013 -6.755650178164588 1.6287155227319094 0.836897647665387 1.2240110569753155 0.6729856296996782 0.117408385892191 0.2903006223877844 1.5166736727126768 0.056903841062295527 0.1373496675391568 1.755293812146265e-07 6.755650178164588 0.38711340930992855 CGLVLSWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CGLVLSWK 8 0 P49756;P49756-2;P49756-3;E9PQU5;E9PSE8 P49756 RBM25 RNA-binding protein 25 0 13278500.0 8086500.0 2402700.0 2789300.0 False True 7829798.483826308 3362110.639914974 2058698.6527936596 1.0 0.4293993832484894 0.26293124363880227 22.900543746556245 -13.999999999999998 0.1727120391321802 3.8985554439474552 0.12024801712962803 0.9995087664578297 0.0069954231968257135 12.119061007079306 0.13165241120328378 11.772444095542976 0.1324399781394903 1.0000000000000041e-14 13.999999999999998 -3.778307426817827 CGLVLSWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CGLVLSWK 8 0 P49756;P49756-2;P49756-3;E9PQU5;E9PSE8 P49756 RBM25 RNA-binding protein 25 0 31629400.0 7468100.0 9344300.0 14817000.0 False True 11329653.691242605 7676736.657650863 11888413.455478197 1.0 0.6775791093760165 1.0493183445375291 23.43360042779162 -6.677374113565397 1.9113316657038935 0.7955178082609937 1.0478711420632592 0.31206043502088443 0.13672949772508106 0.44440514927328256 3.136576253390989 0.05745122903472417 0.1520290598150929 2.101966965781558e-07 6.677374113565397 0.25235333380226543 CGLVLSWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CGLVLSWK 8 0 P49756;P49756-2;P49756-3;E9PQU5;E9PSE8 P49756 RBM25 RNA-binding protein 25 0 35627000.0 11063000.0 9909000.0 14655000.0 False True 15153290.066333618 9471187.615318924 11193790.829199113 1.0 0.6250251644269161 0.7387036597463803 23.853127728342905 -10.551759679701828 9.306787788626904 1.0000214256849396 0.6818644120866487 0.9126069002127936 0.0464090513766755 2.0633279829082165e-05 9.9378435943133e-07 0.04493838730198337 0.01497845692459572 2.8069864765176665e-11 10.551759679701828 -0.31815701359829085 CGLVLSWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CGLVLSWK 8 0 P49756;P49756-2;P49756-3;E9PQU5;E9PSE8 P49756 RBM25 RNA-binding protein 25 0 36289100.0 7468100.0 16383000.0 12438000.0 False True 9667602.668259205 15471271.648185568 10174411.624657305 1.0 1.6003214218744262 1.0524234366873664 23.20472674988407 -10.115244184933644 4.730329781012623 0.9999793658644751 1.3263724292817936 0.32116614103651 0.22367841581469766 5.0265575178912976e-05 9.401838649157666e-06 0.2165898222258026 0.07219189827778387 7.669301565801507e-11 10.115244184933644 0.32639306341731844 CGMTTVLTLTGVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CGMTTVLTLTGVSR 14 0 Q96GD0;B1AHD3;Q6ZT62;Q6ZT62-2 Q96GD0;Q6ZT62 PDXP Pyridoxal phosphate phosphatase 0 4891400.0 1390800.0 1658700.0 1841900.0 False True 1905016.344956774 1585413.149412606 1406881.1551212466 1.0 0.8322307331429116 0.7385139549304862 20.861371945356115 -13.999999997946283 0.0687143771363492 1.9814614459648852 0.38920656362783873 0.9999287079823801 0.0009133003018672746 12.373651276628834 0.07031056928988402 1.9624808232195086 0.32240963935152706 1.0000000047288586e-14 13.999999997946283 -1.5922548823370464 CGNIASIMVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CGNIASIMVFK 11 0 O00743-2;O00743;O00743-3 O00743-2 PPP6C Serine/threonine-protein phosphatase 6 catalytic subunit;Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed 0 18076600.0 5402200.0 6024300.0 6650100.0 False True 7082336.514979224 5125497.922537483 5962011.444263577 1.0 0.7237015512743564 0.84181419954472 22.755793963880116 -10.109961480868721 4.67306845512484 1.0000147164813877 0.7827578754067909 0.8185314489770772 0.048219286751179195 39588860029.140366 7539893041.707689 6646591.042029138 0.016507059417253528 7.763159678157565e-11 10.109961480868721 -0.21725684107459686 CGNIASIMVFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CGNIASIMVFK 11 0 O00743-2;O00743;O00743-3 O00743-2 PPP6C Serine/threonine-protein phosphatase 6 catalytic subunit;Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed 0 16741000.0 3762900.0 7215300.0 5762800.0 False True 5708594.404838833 5927673.341603798 4623780.054075029 1.0 1.0383770366623464 0.8099682209259301 22.444704131934973 -6.863685522501484 1.1669000949472523 1.0210647015522203 0.798099150479505 0.9579689781795261 0.02047359670109198 0.14305743136669435 0.3680665149431558 0.013661969630539368 0.032037007302131916 1.3687195720192518e-07 6.863685522501484 -0.22296555107271532 CGNIASIMVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CGNIASIMVFK 11 0 O00743-2;O00743;O00743-3 O00743-2 PPP6C Serine/threonine-protein phosphatase 6 catalytic subunit;Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed 0 16193200.0 5402200.0 3950800.0 6840200.0 False True 7399539.328965704 3776240.592451506 5224685.638341035 1.0 0.5103345525402245 0.7060825554219107 22.819004025403007 -10.177368563019668 5.368944133777734 1.000015010415775 0.6082085539809747 0.8423057643053133 0.07991378753849017 1.4358920648869554e-05 2.2000948972889394e-06 0.07737915376583837 0.02579206402236366 6.647088131560242e-11 10.177368563019668 -0.3918064564348003 CGNVVYISIPHYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CGNVVYISIPHYK 13 0 Q4G0J3;Q4G0J3-3;D6RFF0 Q4G0J3 LARP7 La-related protein 7 0 20817400.0 4912500.0 8084500.0 7820400.0 False True 6440335.072717665 6878324.11313418 7011220.026573878 1.0 1.0680071821529769 1.08864211992239 22.61870431902629 -13.999999999998964 0.16708482527134283 0.6595759960995679 1.1074211144992487 0.9995195229967716 0.0008301134322239889 12.063860642402139 0.12937183901836433 1.3308015556164143 0.017279735861350544 1.0000000000023846e-14 13.999999999998964 0.4478451183996809 CGNVVYISIPHYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CGNVVYISIPHYK 13 0 Q4G0J3;Q4G0J3-3;D6RFF0 Q4G0J3 LARP7 La-related protein 7 0 15101700.0 4912500.0 5268400.0 4920800.0 False True 6728784.0053207865 5035624.667730971 3758608.387057186 1.0 0.7483706809059484 0.5585865713753133 22.68191438054918 -7.0906638146184875 0.1251591894861194 1.3241093097945555 1.2126805489702352e-10 0.99999922653131 0.00015889895434011787 0.07564498325332744 0.00414750495460877 0.01444122459861096 0.028513271511951065 8.115890621534679e-08 7.0906638146184875 -1.3241093096732874 CGTGIVGVFVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CGTGIVGVFVK 11 0 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 0 19058500.0 0.0 8404500.0 10654000.0 False True 0.0 7150581.360484406 9551626.280384395 0.0 CGTGIVGVFVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CGTGIVGVFVK 11 0 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 0 18883700.0 0.0 7262700.0 11621000.0 False True 0.0 6941809.899462788 8876359.142007705 0.0 CGYAGSNFPEHIFPALVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CGYAGSNFPEHIFPALVGR 19 0 P61160;P61160-2;A0A1B0GWD0;A0A1B0GWH0 P61160 ACTR2 Actin-related protein 2 0 9305300.0 1778200.0 3278800.0 4248300.0 False True 2331237.4201132967 2789615.8206622996 3808726.6685711434 1.0 1.1966245036195096 1.6337789689331779 21.15266450960288 -6.957923483786196 0.4637765010132902 0.9877270766500047 1.8604108735979137 0.9996852499743535 0.00469924074385177 0.08045146013371282 0.0239368342041579 0.005976088228734479 0.03609941796767625 1.1017334014449631e-07 6.957923483786196 0.872683796947909 CGYAGSNFPEHIFPALVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CGYAGSNFPEHIFPALVGR 19 0 P61160;P61160-2;A0A1B0GWD0;A0A1B0GWH0 P61160 ACTR2 Actin-related protein 2 0 11997700.0 1778200.0 2932300.0 7287200.0 False True 2435648.594048131 2802741.290180613 5566113.444595007 1.0 1.150716608721606 2.285269499958505 21.21587457112577 -6.931246717983753 0.7364888494866422 0.9835205507389783 2.525757206035172 0.9967776418874773 0.032564670630411956 0.09199550538587825 0.07454702731379995 0.029891146931748006 0.1019626716278605 1.1715296431901781e-07 6.931246717983753 1.5422366552961937 up CGYAGSNFPEHIFPALVGRPIIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CGYAGSNFPEHIFPALVGRPIIR 23 1 P61160;P61160-2;A0A1B0GWD0;A0A1B0GWH0 P61160 ACTR2 Actin-related protein 2 0 7628600.0 1953600.0 3169200.0 2505800.0 False True 2561188.51868931 2696367.713444846 2246523.8533308785 1.0 1.052779869099489 0.8771411541703062 21.288382017093 -6.826141060027044 1.3450611067960927 1.0282866017385053 0.872776936886801 0.8979212813456929 0.02350931357585212 0.18563240178552498 0.6581645400322094 0.013728236971909257 0.0316023265417435 1.492309624635095e-07 6.826141060027044 -0.15550966485170425 CGYAGSNFPEHIFPALVGRPIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CGYAGSNFPEHIFPALVGRPIIR 23 1 P61160;P61160-2;A0A1B0GWD0;A0A1B0GWH0 P61160 ACTR2 Actin-related protein 2 0 24884400.0 1953600.0 7137000.0 15793800.0 False True 2675898.7140548998 6821663.7410970945 12063629.72352132 1.0 2.549298187284505 4.50825349261475 21.35159207861589 -6.967940692357149 0.3033678894057522 0.6735670900006133 6.445662622548209 0.9999615714441122 0.008898708670630497 0.07697671799686333 0.011409168082285636 0.031969067911698554 0.1750733413277261 1.0766122267200137e-07 6.967940692357149 5.7720955325475956 CHGHFGLFPANYVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CHGHFGLFPANYVK 14 0 E7EVW7;P14317 E7EVW7 HCLS1 Hematopoietic lineage cell-specific protein 0 27956400.0 9504400.0 7240000.0 11212000.0 False True 12460360.440740531 6159820.221298961 10051889.793098347 1.0 0.49435329343754336 0.8067093918272683 23.570842466004247 -10.509891415080224 5.783984386657694 1.000511243534292 0.6505313426324084 0.6253272355659869 0.12751884318356785 0.0008418713570600004 7.133608601180119e-05 0.12364445537089196 0.041156529664799386 3.091068183373674e-11 10.509891415080224 -0.3499799009018836 CHGHFGLFPANYVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CHGHFGLFPANYVK 14 0 E7EVW7;P14317 E7EVW7 HCLS1 Hematopoietic lineage cell-specific protein 0 25801100.0 9504400.0 7577100.0 8719600.0 False True 13018433.526752362 7242318.667881019 6660210.065799022 1.0 0.5563126049688193 0.5115984232751626 23.63405252752714 -13.999999999999998 0.3243538467843456 5.6689068480610585 0.503146331190982 0.9997030045331348 0.0037991771659666596 18.357727213848893 0.18183197199181617 58.29769659776018 0.014638230714764477 1.0000000000000041e-14 13.999999999999998 -5.165760516870076 CHGHFGLFPANYVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CHGHFGLFPANYVK 14 0 E7EVW7;P14317 E7EVW7 HCLS1 Hematopoietic lineage cell-specific protein 0 10596900.0 5318700.0 2295800.0 2982400.0 False True 4422734.708360921 2283432.0697193802 3606006.0509404284 1.0 0.5162941528920298 0.8153340158801489 22.076507276084644 -10.328898425837497 6.26836706581887 1.0000207623800843 0.6658140843860906 0.6247884805514805 0.12208251284544777 3.5425373626278876e-05 3.792833530323235e-06 0.1182132176669798 0.03940196159279763 4.689230425203314e-11 10.328898425837497 -0.33420667799399373 CHK(ub)EK(ub)VSGQVGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CHKEKVSGQVGSR 13 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 15113600.0 1419800.0 4222100.0 9471700.0 True False 1861371.5493627605 3592179.137616897 8491659.342961973 1.0 1.9298560455845999 4.562044233387518 20.827934630589418 -6.952748434023006 0.5278089375676356 0.9578225245432591 5.653121658758364 0.9993996932162594 0.036960950304129596 0.08240052990962604 0.0315375129854836 0.04137000756485474 0.21760784927606452 1.114940177982638e-07 6.952748434023006 4.695299134215105 CHK(ub)EK(ub)VSGQVGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CHKEKVSGQVGSR 13 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 18312500.0 3950600.0 5613400.0 8748500.0 True False 3825190.365449107 7854859.893494277 6457005.400625727 1.0 2.0534559441650315 1.6880219763566264 21.867100116464204 -10.171094125527768 5.754485143365635 0.999985210229439 1.8707389602608613 0.8833141190513172 0.14918779263532186 2.830820693671657e-05 4.07731066372473e-06 0.14445290729157892 0.04815015302782062 6.743818517054749e-11 10.171094125527768 0.8707537500314223 CHK(ub)EK(ub)VSGQVGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CHKEKVSGQVGSR 13 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 14260200.0 1419800.0 3401700.0 9438700.0 True False 1944738.4286523103 3251401.6460823882 7209473.456128399 1.0 1.6718966407917317 3.707168712208002 20.89114469211231 -6.9512330080061995 0.5451382732040606 0.9710070732633861 4.502878731903269 0.9992945322169147 0.030570442366369598 0.08299436119287737 0.03394217576259404 0.0333916634493785 0.16869404475946947 1.118837442890145e-07 6.9512330080061995 3.5318716586398824 CHK(ub)EK(ub)VSGQVGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CHKEKVSGQVGSR 13 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 17049600.0 3950600.0 5588700.0 7510300.0 True False 3285098.941254567 5558592.563829911 9080669.006296258 1.0 1.692062450243007 2.7641995473135994 21.64750539189848 -6.964715695431691 0.3629036146846351 0.9106249111231852 3.5825440721083974 0.9999071580917407 0.006993228935103364 0.07805761953073341 0.015201277663414526 0.014302967654770016 0.09141743555174453 1.084636723323922e-07 6.964715695431691 2.671919160985212 CHQGPIK(ub)PYQQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CHQGPIKPYQQGR 13 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 4127570.0 773870.0 1852200.0 1501500.0 True False 1014551.064167741 1575858.979819053 1346139.1834050259 1.0 1.5532574312676568 1.3268323605862993 19.952410049665236 -10.104624162605337 4.504787459685066 0.9999601867428103 1.4400448958151515 0.8343267213599281 0.09243764808474245 48662208.32125578 1.1765219469625148 20563.594795476034 0.0338287153061886 7.859154697512476e-11 10.104624162605337 0.4400847090723412 CHTFTFSHATFCGPVRPYFSLSYSGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CHTFTFSHATFCGPVRPYFSLSYSGGK 27 1 P14373;A0A140T9V9;H0Y551;A0A140T9B9;A0A140T9N6 P14373 TRIM27 Zinc finger protein RFP 0 395777000.0 91347000.0 109430000.0 195000000.0 False True 138580077.36023065 89901361.51950753 156458164.52846375 1.0 0.6487322220625862 1.1290090719300154 27.046144625812612 -6.710617340795219 1.7927895245570036 0.7841894116738998 1.1279127332781886 0.4681492359314223 0.14800756162697887 0.3738271146076058 2.342483930154268 0.0656858115193419 0.1667614316817622 1.9470749042166018e-07 6.710617340795219 0.34372332160428887 CHTFTFSHATFCGPVRPYFSLSYSGGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CHTFTFSHATFCGPVRPYFSLSYSGGK 27 1 P14373;A0A140T9V9;H0Y551;A0A140T9B9;A0A140T9N6 P14373 TRIM27 Zinc finger protein RFP 0 298483000.0 91347000.0 116940000.0 90196000.0 False True 118250492.21856615 110432186.20147844 73781253.48911315 1.0 0.9338835224242713 0.6239403498865858 26.81727094790506 -6.941253509344826 0.6478017936658489 1.003417746383236 0.5371848903472413 0.9983234552494998 0.006712209575786131 0.08719954533634926 0.052041195239914274 0.00659761311920122 0.026532352276582932 1.1448444699193236e-07 6.941253509344826 -0.46623285603599485 CHTTHSMALIHNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CHTTHSMALIHNR 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 10135900.0 2425700.0 2626300.0 5083900.0 False True 3180116.1905122176 2234466.2772372207 4557866.796212336 1.0 0.7026366784659267 1.4332390778080992 21.600648046913513 -6.796204935674583 1.4713232915803132 0.8351316969958785 1.4424074293795353 0.8208320866380963 0.1269769251702875 0.22622760089583369 0.9671991680974167 0.06790521492138984 0.15830389535238404 1.5988034043067805e-07 6.796204935674583 0.6072757323836567 CHTTHSMALIHNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CHTTHSMALIHNR 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 8097500.0 2425700.0 2803900.0 2867900.0 False True 3322546.842077692 2680014.426742629 2190561.0862545334 1.0 0.8066144900659197 0.6593017917799189 21.663858108436404 -6.974144141364621 0.1241784186731097 1.2488265397841294 0.21329338098076714 0.9999993586012462 0.0001115828289408485 0.07497948102190587 0.003710176112760724 0.00989102256249452 0.020747856230731086 1.061343241293848e-07 6.974144141364621 -1.0355331588033623 CHWSDMFTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CHWSDMFTGR 10 0 P46060;H0Y4Q3;B0QYT5;B0QYT4 P46060 RANGAP1 Ran GTPase-activating protein 1 0 5303690.0 1585700.0 714990.0 3003000.0 False True 2078868.0559406443 608316.2790091912 2692278.3668100517 1.0 0.2926189939139455 1.2950693812031528 20.98736676374902 -6.71712155475262 1.7699338024226898 0.5683203580729406 1.2932348387771964 0.4988303676407715 0.2977774671683624 0.36091518008023515 2.208069708202445 0.13367706723328016 0.3366877751633215 1.9181317993126615e-07 6.71712155475262 0.7249144807042558 CHWSDMFTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CHWSDMFTGR 10 0 P46060;H0Y4Q3;B0QYT5;B0QYT4 P46060 RANGAP1 Ran GTPase-activating protein 1 0 2793300.0 1585700.0 0.0 1207600.0 False True 2171976.141931234 0.0 922389.7513026851 1.0 0.0 0.4246776626572579 21.05057682527191 -10.762882396840055 6.690467798579703 1.02041323085467 0.21233883132863401 0.8210029250237773 0.17337392977801466 0.04928064353648809 0.0017465587186904585 0.15670827983640204 0.055956195224732115 1.7263052971289493e-11 10.762882396840055 -0.808074399526036 CIALAQLLVEQNFPAIAIHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CIALAQLLVEQNFPAIAIHR 20 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;A0A140T9X9;H0Y400;F6UJC5;A0A140TA18;H0YCC6 Q13838-2 DDX39B Spliceosome RNA helicase DDX39B 0 123981000.0 32592000.0 45040000.0 46349000.0 False True 49444446.79436262 37002260.10087379 37188099.83451161 1.0 0.7483602810799894 0.7521188373120111 25.559305162301772 -9.977449011663198 5.120842399626794 1.0000014494431684 0.7502395591938101 0.9998301801480263 0.0015344241639602635 2.539192198429854e-08 5.06906268414852e-09 0.0014857084275683352 0.0004952332683247236 1.0532973422285717e-10 9.977449011663198 -0.24976189024935824 CIALAQLLVEQNFPAIAIHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CIALAQLLVEQNFPAIAIHR 20 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;A0A140T9X9;H0Y400;F6UJC5;A0A140TA18;H0YCC6 Q13838-2 DDX39B Spliceosome RNA helicase DDX39B 0 72058000.0 32592000.0 22146000.0 17320000.0 False True 42190986.48436743 20913555.63210144 14167937.718207443 1.0 0.49568776117264557 0.3358048459819003 25.33043148439422 -13.999999999999998 0.16076565117816893 3.4877284738921275 0.17995232228890598 0.9995343743777888 0.0061077218469743795 12.014885568345628 0.12673361216146417 9.319730487029194 0.14218343658015795 1.0000000000000041e-14 13.999999999999998 -3.3077761516032216 CIDSGLWVPNSK(ub)ASEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CIDSGLWVPNSKASEAK 17 1 Q16543;K7EL68 Q16543 CDC37 Hsp90 co-chaperone Cdc37;Hsp90 co-chaperone Cdc37, N-terminally processed 1 13387400.0 4936300.0 6111900.0 2339200.0 True False 6471537.103197194 5200028.343999604 2097162.0231908355 1.0 0.8035229128842645 0.32405933702439177 22.625676987536256 -6.955978039600271 0.48883866750008775 1.0106039808260796 0.09668708887032716 0.9995907016487089 0.005743579188735859 0.08117049815855057 0.02668825071037862 0.006886076407260306 0.039544779301246426 1.1066797425866066e-07 6.955978039600271 -0.9139168919557524 down CIDSGLWVPNSK(ub)ASEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CIDSGLWVPNSKASEAK 17 1 Q16543;K7EL68 Q16543 CDC37 Hsp90 co-chaperone Cdc37;Hsp90 co-chaperone Cdc37, N-terminally processed 1 30245700.0 12490000.0 11972000.0 5783700.0 True False 18948243.1413104 9835503.062337052 4640549.159914239 1.0 0.5190720315855551 0.24490656602337188 24.175560753831203 -8.820762145342124 0.22165416122270226 1.3280876975816405 5.512697114837354e-21 0.9994737137923906 0.0071597260005447855 0.3379916114694504 0.0677381564291462 0.20699620079939524 0.12492745688117163 1.510907422271873e-09 8.820762145342124 -1.3280876975816405 down CIDSGLWVPNSK(ub)ASEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CIDSGLWVPNSKASEAK 17 1 Q16543;K7EL68 Q16543 CDC37 Hsp90 co-chaperone Cdc37;Hsp90 co-chaperone Cdc37, N-terminally processed 1 15501800.0 4936300.0 6415700.0 4149800.0 True False 6761383.508491604 6132233.160117229 3169702.70781375 1.0 0.9069494656553313 0.4687949890481628 22.688887049059147 -6.941152393606976 0.6487546368619669 1.0048370304790033 0.3465225443706562 0.9983109719061498 0.009518930563852264 0.08724482625112953 0.052245016228745944 0.009348960294123165 0.037523739833908366 1.1451110523315799e-07 6.941152393606976 -0.6583144861083471 down CIDSGLWVPNSK(ub)ASEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CIDSGLWVPNSKASEAK 17 1 Q16543;K7EL68 Q16543 CDC37 Hsp90 co-chaperone Cdc37;Hsp90 co-chaperone Cdc37, N-terminally processed 1 12933800.0 7394000.0 3611100.0 1928700.0 True False 6148438.609739354 3591646.287552774 2331982.2526987717 1.0 0.584155834598962 0.3792803995806066 22.55178865522551 -11.737101792548273 0.11856583225226829 2.222280698354389 3.705347713860502e-12 0.9997828588959914 0.0038053514987290704 4.878023694817144 0.08072815860987044 1.7977818997441914 0.2769198404267433 1.8318850038420683e-12 11.737101792548273 -2.2222806983506835 CIDSGLWVPNSK(ub)ASEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CIDSGLWVPNSKASEAK 17 1 Q16543;K7EL68 Q16543 CDC37 Hsp90 co-chaperone Cdc37;Hsp90 co-chaperone Cdc37, N-terminally processed 1 30249000.0 12490000.0 13325000.0 4434000.0 True False 16168551.214707559 12583452.036383625 3627057.4966819813 1.0 0.7782671353347488 0.22432792205789379 23.946687075923652 -7.012743494354819 0.5147461558163018 1.009352564770647 1.128479422711712e-13 0.9995328588843498 0.007050390102286811 0.07485306719089731 0.0286739823592729 0.008237215628571257 0.04169103027700834 9.710833450473315e-08 7.012743494354819 -1.0093525647705341 down CIELCCGSVK(ub)EMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CIELCCGSVKEMR 13 1 P05023-4;P05023;P05023-3;P05023-2 P05023-4 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 1 8988300.0 1481300.0 2504600.0 5002400.0 True False 1941998.6449296062 2130923.442854332 4484799.634409126 1.0 1.0972836919418003 2.30937320482615 20.889110763410827 -6.922858771081706 0.8032380413076708 0.9759106630214793 2.518292361048438 0.9949389457710339 0.04237447791539412 0.09651867207511618 0.09711056514258853 0.037074019810063426 0.11428021083438278 1.1943764425074027e-07 6.922858771081706 1.5423816980269587 up CIESLIAVFQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CIESLIAVFQK 11 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 290327250.0 56466000.0 139390000.0 94471250.0 False True 74027472.8175218 118593555.3379643 84696271.28221925 1.0 1.6020208555585598 1.1441194472624523 26.141557442278874 -10.194056352259352 5.176374878995847 0.9999748855280556 1.3730701514106978 0.4695146680820832 0.18693746713855028 5.4184829150739904e-05 8.436094219271072e-06 0.18101359144741974 0.060333808084053926 6.396518315162458e-11 10.194056352259352 0.3730952658826422 CIESLIAVFQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CIESLIAVFQK 11 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 97206000.0 52553000.0 23771000.0 20882000.0 False True 50884733.78105779 33262884.26412738 15412377.753428172 1.0 0.6536908379485269 0.302888049286907 25.600729554267353 -7.373054008500009 0.29226571902560045 1.0865102800218274 5.138496353151119e-13 0.9998331602643251 0.003676030629739387 0.11369157045896365 0.023686912532417306 0.01688674701992848 0.05491519036320089 4.2359028543889713e-08 7.373054008500009 -1.0865102800213136 down CIESLIAVFQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CIESLIAVFQK 11 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 194111800.0 27127800.0 110260000.0 56724000.0 False True 41154855.9078335 90583241.53468803 45512476.53698754 1.0 2.201034107312868 1.105883510779699 25.29455933011567 -6.624165728071369 2.1013709237245366 1.794580393399625 1.1101521681938427 0.0969844722236044 0.5159397585021196 0.5743486080132825 4.824942201911848 0.2013373960511398 0.571893368658937 2.3759334503094975e-07 6.624165728071369 -0.6844282252057823 CIESLIAVFQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CIESLIAVFQK 11 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 281192000.0 56466000.0 93676000.0 131050000.0 False True 77343006.13627352 89537084.57489307 100098689.05947071 1.0 1.1576623284739458 1.2942177199978897 26.204767503801765 -6.972805015562934 0.17891956628400082 0.8929117852611728 1.5626570010416119 0.99999680191201 0.00021490867127974545 0.07540259110621363 0.00563568914302266 0.005309187248042138 0.015375193599752915 1.0646208919286696e-07 6.972805015562934 0.6697452157804391 CIESLIAVFQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CIESLIAVFQK 11 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 105579000.0 52553000.0 14379000.0 38647000.0 False True 43700147.992647 14301537.472991956 46727909.0164615 1.0 0.3272651954267601 1.069284914648892 25.38113482970163 -6.667996100674807 1.944498722837508 0.5698571257451042 1.0662590072314844 0.2701848602307476 0.285895996400732 0.46573880379395294 3.39308591931148 0.11844791389435774 0.31728981539153345 2.1478497585732926e-07 6.667996100674807 0.4964018814863802 CIESLIAVFQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CIESLIAVFQK 11 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 105310800.0 27127800.0 41863000.0 36320000.0 False True 35117471.86888261 39533287.24946546 29710132.674670603 1.0 1.1257441138436755 0.8460213988523638 25.06568565220812 -6.784489892242401 1.518263998513205 1.0707841117211894 0.8434808018200698 0.7829955382155498 0.05328716901703415 0.2436575857021555 1.1095833280349552 0.027635365556488056 0.06497063193994818 1.6425178871450544e-07 6.784489892242401 -0.22730330990111958 CIESLIAVFQK(ub)YAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CIESLIAVFQKYAGK 15 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 3849600.0 1451300.0 1359300.0 1039000.0 True False 1405229.2759014561 1902075.5786558571 766854.7306681297 1.0 1.3535695642518362 0.545715025881589 20.42237410775619 -6.787714883776464 1.5052315432070693 1.1981930296218632 0.5376275859230429 0.7939319522354107 0.1501014831166799 0.23875789903973088 1.068679027829481 0.07849880519596658 0.18411277058383027 1.6303660237872955e-07 6.787714883776464 -0.6605654436988203 CIESLIAVFQK(ub)YAGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CIESLIAVFQKYAGK 15 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 20348800.0 4054100.0 5780700.0 10514000.0 True False 6150366.094410454 4749088.920184747 8435903.291550094 1.0 0.7721636155123824 1.3716099435473883 22.552240857316047 -6.803721523573119 1.4407974069964709 0.8748797170698702 1.3806529090422364 0.8427841713688505 0.09795964477142735 0.21549096694065115 0.8827436871797217 0.05347943209177462 0.1240952325369146 1.5713700684724167e-07 6.803721523573119 0.5057731919723661 CIESLIAVFQK(ub)YAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CIESLIAVFQKYAGK 15 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 3264280.0 978980.0 1053900.0 1231400.0 True False 1340935.3619397366 1007335.2132187515 940568.6814790724 1.0 0.7512183225309129 0.7014273082622626 20.35480826498824 -13.999999999999998 0.22616022842356792 2.543089821607066 0.6763167445714919 0.9995047956887051 0.0029063539592322717 13.174555944717275 0.1506060088810576 9.109499940471196 0.02647771971451345 1.0000000000000041e-14 13.999999999999998 -1.8667730770355742 CIESLIAVFQK(ub)YAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CIESLIAVFQKYAGK 15 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 17145300.0 4054100.0 4799200.0 8292000.0 True False 5248112.368258285 4532120.301164142 6782941.083104862 1.0 0.8635715059333299 1.2924534779646777 22.323367179408496 -6.821139651544988 1.3668003544501814 0.9265451569864677 1.3020563922150816 0.8869915898954991 0.06014393283958421 0.19202069942147326 0.7045358184484293 0.03457468993521314 0.07967122703334267 1.5095946515087927e-07 6.821139651544988 0.37551123522861396 CIGK(ub)PGGSLDNSEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CIGKPGGSLDNSEQK 15 1 Q9Y5L4;K7EIT2 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 1 13442000.0 3675900.0 6073000.0 3693100.0 True False 4819140.497466236 5166932.072368586 3310973.4387166854 1.0 1.0721687975449583 0.6870464640857635 22.200344431419524 -6.858276054465455 1.194585784532084 1.0389865399832816 0.6690178113792129 0.9514865275504759 0.03681720542635299 0.14859421583321034 0.40394515484492033 0.024055700173509414 0.05604245610381987 1.3858746330172498e-07 6.858276054465455 -0.3699687286040687 CIGK(ub)PGGSLDNSEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CIGKPGGSLDNSEQK 15 1 Q9Y5L4;K7EIT2 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 1 11811400.0 6299200.0 4247800.0 1264400.0 True False 6099235.344007759 5943968.691984366 933215.7088130733 1.0 0.9745432593979282 0.1530053615212468 22.54019695387567 -6.913509665908649 0.8715094522475408 1.0227014422731588 0.0384681817279569 0.9921794765506851 0.03479108067927509 0.10214285483999319 0.1265231364522554 0.02898760579876636 0.08210344944611864 1.220366659257338e-07 6.913509665908649 -0.984233260545202 down CIGK(ub)PGGSLDNSEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CIGKPGGSLDNSEQK 15 1 Q9Y5L4;K7EIT2 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 1 81665000.0 18382000.0 15423000.0 47860000.0 True False 27886837.904208783 12670645.149550997 38400450.02221681 1.0 0.4543593358657095 1.37700983360402 24.733081020286374 -6.746458071551099 1.6628287259707495 0.6778001775929434 1.3783735395664292 0.633647354965778 0.2292533902063416 0.3062614001561538 1.6649352709286502 0.1089610855009122 0.26553218642984844 1.7928416317928386e-07 6.746458071551099 0.7005733619734857 CIGK(ub)PGGSLDNSEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CIGKPGGSLDNSEQK 15 1 Q9Y5L4;K7EIT2 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 1 11698700.0 3675900.0 4487800.0 3535000.0 True False 5034979.567462332 4289514.156829975 2700105.8056102963 1.0 0.8519427138394372 0.5362694663269846 22.263554492942415 -6.958774764335856 0.4523706679414396 1.0099367279168696 0.36571155187775617 0.9997220222171614 0.0032244142802508122 0.08014173447584537 0.022770661129982335 0.004234472840988468 0.02610248224705893 1.09957595837363e-07 6.958774764335856 -0.6442251760391134 CIGK(ub)PGGSLDNSEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CIGKPGGSLDNSEQK 15 1 Q9Y5L4;K7EIT2 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 1 11991900.0 6299200.0 1684400.0 4008300.0 True False 5238063.9018758675 1675325.802872778 4846416.997714769 1.0 0.31983683938502666 0.9252305982710823 22.320602229309948 -10.601510732148 9.269651203538523 1.0000763873846827 0.6225337188280892 0.3413882953246883 0.2471509671227243 0.0003902440529886418 1.6775909323121505e-05 0.23935068535390247 0.07976763163878066 2.503163790226279e-11 10.601510732148 -0.3775426685565936 CIGK(ub)PGGSLDNSEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CIGKPGGSLDNSEQK 15 1 Q9Y5L4;K7EIT2 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 1 71760000.0 18382000.0 19947000.0 33431000.0 True False 23795861.363391057 18836931.915177796 27346901.03102731 1.0 0.7916053816046194 1.149229297204571 24.504207342378823 -6.748718301529352 1.6545609716189038 0.8772800403276674 1.1498747238948315 0.6435518042907714 0.08756313300192733 0.30223355943755564 1.6274781756860592 0.0418137286717467 0.1016504969888239 1.7835352551923263e-07 6.748718301529352 0.2725946835671641 CIGKPGGSLDNSEQK(ub)CIAMCMDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CIGKPGGSLDNSEQKCIAMCMDR 23 2 Q9Y5L4;K7EIT2 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 1 44578000.0 11427000.0 16342000.0 16809000.0 True False 14980907.659225402 13903837.300617075 15069765.92331341 1.0 0.928103798307237 1.0059314339364 23.836621700277455 -9.975605752434223 4.375790092910304 1.0000009392609284 0.9670176161205954 0.19319780907454642 0.03177299922706869 43688714.904710874 0.0012239927779679654 477.95068627122276 0.010876742743126219 1.057777311649813e-10 9.975605752434223 -0.03298332314033292 CIGKPGGSLDNSEQK(ub)CIAMCMDR ddPTM_RPMI8226_Bortezomib_8h_R1 2 CIGKPGGSLDNSEQKCIAMCMDR 23 2 Q9Y5L4;K7EIT2 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 1 619362200.0 61055400.0 118643800.0 439663000.0 True False 92625505.54763527 97470886.92175958 352763415.33886164 1.0 1.0523115241906285 3.8084911197320603 26.464906175844053 -6.911011151331871 0.8888330329072546 0.9173680525067525 4.172478627814808 0.9912972944207263 0.1223736530745537 0.10375289887627177 0.13517301077334054 0.10069253767099125 0.2799388734916517 1.2274077147402567e-07 6.911011151331871 3.2551105753080556 up CIGKPGGSLDNSEQK(ub)CIAMCMDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CIGKPGGSLDNSEQKCIAMCMDR 23 2 Q9Y5L4;K7EIT2 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 1 39911000.0 11427000.0 17826000.0 10658000.0 True False 15651870.703063749 17038388.377300937 8140799.908400148 1.0 1.088584789674105 0.5201167363851684 23.899831761800346 -6.867084282454085 1.1493438591926377 1.0493214654452114 0.4886095227773743 0.9616889932711861 0.04888038498310005 0.1396846758330117 0.3466881128265073 0.0330597113886819 0.07790142399600762 1.358049867638847e-07 6.867084282454085 -0.5607119426678371 CIGKPGGSLDNSEQK(ub)CIAMCMDR ddPTM_RPMI8226_Carfilzomib_8h_R1 3 CIGKPGGSLDNSEQKCIAMCMDR 23 2 Q9Y5L4;K7EIT2 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 1 423837400.0 69255400.0 99757000.0 254825000.0 True False 89652480.52802718 94205435.25654934 208449464.72530118 1.0 1.0507844813853067 2.325083070737074 26.417840164717074 -6.915297925957623 0.8588691773630651 0.9668435750156755 2.5098887913819463 0.9927721130958288 0.05211802890561625 0.10101811971105955 0.12053266970253086 0.04382067124070898 0.12590313690403762 1.2153519833100392e-07 6.915297925957623 1.543045216366271 up CIHSFQNLGIQCVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CIHSFQNLGIQCVK 14 0 Q2TAM5;E9PKH5;A0A087X0W8;Q04206-2;Q04206-3;Q04206-4;Q04206;E9PI38;E9PQS6;E9PKV4;A0A087WVP0;E9PRX2;E9PMD5 Q2TAM5 RELA Transcription factor p65 0 4496810.0 732310.0 1630600.0 2133900.0 False True 960065.5017001289 1387320.8360290176 1913104.4978141761 1.0 1.4450272752976594 1.992681222714868 19.872773313347913 -6.968337923253817 0.2952000791961636 0.8994342657940217 2.555318269955342 0.9999663592808942 0.0023547118426836314 0.07684579698139919 0.010950423046351786 0.009309199185553814 0.049372454234435585 1.0756279450064736e-07 6.968337923253817 1.65588400416132 CIIPWYIMTSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CIIPWYIMTSGR 12 0 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 0 15922800.0 2843900.0 6711300.0 6367600.0 False True 3728380.440366777 5710000.200442509 5708741.834332239 1.0 1.5314961259374034 1.5311586158226507 21.830117648046787 -10.017724275991554 4.623927361060603 0.9999847544864807 1.5313273709054323 0.9999996968393625 0.00013778802895941442 95131.0320724202 0.0015545710849923585 15.450294367418818 4.716849204639297e-05 9.600099272557982e-11 10.017724275991554 0.5313426164189515 CIIPWYIMTSGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CIIPWYIMTSGR 12 0 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 0 7421000.0 4152600.0 1597700.0 1670700.0 False True 4020777.986018315 2235669.941895434 1233093.5500743436 1.0 0.5560291937703746 0.306680337577019 21.939043246841923 -9.135871282485434 0.17989590094611496 1.461404393714303 3.140801402516205e-10 0.9996850156988065 0.005088995366217708 0.5804416395811467 0.06203142673239568 0.30261192664169456 0.1532899793260534 7.313558128163739e-10 9.135871282485434 -1.461404393400223 CIIPWYIMTSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 CIIPWYIMTSGR 12 0 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 0 26308660.0 3347340.0 8815320.0 14146000.0 False True 4584942.056462185 8425830.014035044 10805006.14601506 1.0 1.837717883949999 2.356628723537757 22.128472070781825 -8.72151777573168 0.15375023803901638 6.309895252335223e-20 3.2457483640235556 0.9998595500545715 0.0066237961757966415 0.2770232376460748 0.04401555367445306 0.4805531402486631 0.35600525770866576 1.8988131218338175e-09 8.72151777573168 3.2457483640235556 CIK(ub)FSSSDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CIKFSSSDR 9 1 O14776;O14776-2;G3V220 O14776 TCERG1 Transcription elongation regulator 1 1 4664100.0 1618800.0 1167200.0 1878100.0 True False 2455837.950132368 958904.0406247752 1506892.7117995282 1.0 0.3904590042568122 0.6135961502338978 21.227783936117945 -10.179147581673249 5.336006237594581 1.0000207554267933 0.5020275772452183 0.8691197680823189 0.09109535838460951 2.2493908919692477e-05 3.460356781171538e-06 0.08820637120159827 0.029400900494963217 6.619915079438712e-11 10.179147581673249 -0.49799317818157496 CIK(ub)FSSSDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CIKFSSSDR 9 1 O14776;O14776-2;G3V220 O14776 TCERG1 Transcription elongation regulator 1 1 5508900.0 2245900.0 2438000.0 825000.0 True False 1867565.3602398704 2424866.0100948876 997503.6856309883 1.0 1.2984102520424974 0.5341198262013538 20.832727304035537 -6.800825067114994 1.4525934051614091 1.164478736774055 0.5233615885820924 0.8345273572983724 0.12793626249514867 0.21959724682944667 0.9147003810509114 0.06928521980648204 0.1610478444698618 1.5818850908790157e-07 6.800825067114994 -0.6411171481919626 CIK(ub)FSSSDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CIKFSSSDR 9 1 O14776;O14776-2;G3V220 O14776 TCERG1 Transcription elongation regulator 1 1 4296800.0 1618800.0 1334600.0 1343400.0 True False 2095568.5113185428 1260328.3367923135 1098914.9844480304 1.0 0.6014254986105456 0.5243994546170133 20.998910258210394 -13.999999999999973 0.23111681862297098 3.5291571310258187 0.4873444859970287 0.9995113388676784 0.0046075007931311324 13.326335058746373 0.15221098822557216 15.476327236178589 0.03970748031210985 1.0000000000000614e-14 13.999999999999973 -3.04181264502879 CITDTLQELVNQSK(ub)AAPQSPSVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CITDTLQELVNQSKAAPQSPSVPK 24 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 4270000.0 2005700.0 2264300.0 0.0 True False 1942030.1513646713 3168446.7981685093 0.0 1.0 1.6315126703578886 0.0 20.88913416909601 -6.816594561407373 1.4855921830642915 1.3467089859738992 2.573595272844292e-21 0.8366889379255884 0.27144627714480907 0.20963887707976123 0.9260308799700535 0.1457652274471967 0.3214941671078697 1.5254762080342006e-07 6.816594561407373 -1.3467089859738992 CIVNSISLK(ub)EGEDDFLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CIVNSISLKEGEDDFLEK 18 1 Q99707;Q99707-2 Q99707 MTR Methionine synthase 1 32475700.0 3219000.0 4815700.0 24441000.0 True False 4167058.9559762734 4547702.061659476 19992988.785837647 1.0 1.0913457452137305 4.797865592269648 21.99059808090601 -6.912199354221093 0.8806287074440416 0.8930674523532462 5.30010029578393 0.9917253321978323 0.16093505864606594 0.10298136572643245 0.1310128866980433 0.13320968696642882 0.3735688926340185 1.224054192619263e-07 6.912199354221093 4.4070328434306845 up CIWLNSQFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CIWLNSQFR 9 0 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 10183700.0 4258600.0 3087100.0 2838000.0 False True 5833119.504337734 2950701.714325469 2167722.8504447034 1.0 0.5058531223526644 0.3716232538751693 22.475836200573283 -13.999999999999998 0.18289553439526507 3.587182559531189 0.2681253202602213 0.999494930831682 0.0060723278800074 12.243577442555594 0.1355946366826008 11.264706642579636 0.09780807265171668 1.0000000000000041e-14 13.999999999999998 -3.3190572392709674 CIYCIHALSLYLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CIYCIHALSLYLFK 14 0 P46940;A0A0J9YXZ5;H0YKA5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 7987060.0 2738100.0 3684860.0 1564100.0 False True 3589675.615798117 3135093.251471784 1402261.93590663 1.0 0.8733639434366376 0.39063750767208405 21.775422048853333 -6.945981995835777 0.6013405396654902 1.0054215865054414 0.23381195439422411 0.9988470529312843 0.008914842724222513 0.08514042075833597 0.04295691592873392 0.009137625130312675 0.04058491290037419 1.1324473091341655e-07 6.945981995835777 -0.7716096321112174 down CIYCIHALSLYLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CIYCIHALSLYLFK 14 0 P46940;A0A0J9YXZ5;H0YKA5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 342086000.0 84924000.0 107821000.0 149341000.0 False True 128835916.77603257 88579500.14068186 119823685.89151447 1.0 0.687537313796337 0.9300487697061612 26.94095960201766 -9.83308557378695 5.747934558618147 1.0000000375106914 0.8087930428798854 0.45321153044743345 0.09900488729535797 4.7575574374389163e-08 9.692043241830609e-09 0.09586108849073799 0.03195368997367444 1.468636867563381e-10 9.83308557378695 -0.19120699463080604 CIYCIHALSLYLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CIYCIHALSLYLFK 14 0 P46940;A0A0J9YXZ5;H0YKA5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 27578700.0 2738100.0 4971300.0 19869300.0 False True 3750449.564370251 4751651.528109297 15176580.561078543 1.0 1.2669551867196382 4.046603027343173 21.838632110376224 -6.925545066053871 0.7824973093877353 0.9500311607305229 4.55748681242906 0.9955878549466584 0.0915042310906425 0.09501784361650278 0.08950299614421592 0.0812525029401455 0.257944539149036 1.1870115203380251e-07 6.925545066053871 3.607455651698537 up CIYCIHALSLYLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CIYCIHALSLYLFK 14 0 P46940;A0A0J9YXZ5;H0YKA5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 254168000.0 84924000.0 80874000.0 88370000.0 False True 109935792.10230799 76373290.8060405 72287566.752771 1.0 0.6947081505081284 0.6575435112660948 26.71208592411011 -13.999999999999998 0.2970495702162565 3.7380792084150896 0.6481166165495232 0.9996432396371722 0.0028979537884996948 16.39877588178357 0.17300883720217378 27.55086706490177 0.01360380179931501 1.0000000000000041e-14 13.999999999999998 -3.089962591865566 CIYNLLQSSSPAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CIYNLLQSSSPAVK 14 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 6678300.0 1058300.0 3289900.0 2330100.0 False True 1387441.5485917786 2799059.7439297615 2089003.6038974696 1.0 2.017425344347474 1.505651611787005 20.403995562889214 -10.147391143033273 4.714096377336682 0.9999271530240651 1.761538478074067 0.7469853676928171 0.20893075144554502 0.00015997616528370357 2.893379912573217e-05 0.20231555127943154 0.06743211006828145 7.122112951191292e-11 10.147391143033273 0.761611325050002 CIYNLLQSSSPAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CIYNLLQSSSPAVK 14 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 8189500.0 1058300.0 3910100.0 3221100.0 False True 1449582.1094821368 3737338.853028415 2460342.5206368705 1.0 2.5782181144354626 1.6972771011335315 20.467205624412106 -10.624961500273342 7.047604969119459 0.9974122475671676 2.137747607784496 0.6898273651862499 0.35964266268001654 0.0146304209976439 0.0007785572703554386 0.34839850831959035 0.11607417026211628 2.3715839346424422e-11 10.624961500273342 1.1403353602173285 CK(ub)AEHDQLLLNYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CKAEHDQLLLNYAK 14 1 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 20520500.0 5056400.0 8164700.0 7299400.0 True False 6628989.366247249 6946558.58575133 6544128.108788974 1.0 1.0479061289675684 0.9871984622738479 22.66035750792127 -6.6962849138350435 1.8437159617020957 1.0298540948851795 0.9873885118446016 0.40020267119925923 0.020235647922388418 0.40327272555378296 2.6623326659010575 0.008764018013016189 0.02264605402477737 2.0124036027743778e-07 6.6962849138350435 -0.0424655830405779 CK(ub)AEHDQLLLNYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CKAEHDQLLLNYAK 14 1 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 16899100.0 6956100.0 6140100.0 3802900.0 True False 6735282.413076631 8591873.950198501 2806806.405445457 1.0 1.2756516242759586 0.4167318062262703 22.683307009058232 -6.820341672017127 1.3703289537084742 1.1485272412856873 0.3978338374766125 0.8851722233025042 0.12133657730465133 0.19304476639541857 0.7121888737632394 0.06957830469889799 0.160357566372258 1.512370954351006e-07 6.820341672017127 -0.7506934038090748 down CK(ub)AEHDQLLLNYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CKAEHDQLLLNYAK 14 1 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 37141900.0 18605000.0 11855000.0 6681900.0 True False 28225145.207692537 9739382.626462245 5361219.536219189 1.0 0.34506049675903366 0.18994479910622503 24.750477667349017 -13.99999999999993 0.20234021630147778 4.6735809377012645 0.09149700122659304 0.9994871799402616 0.007949966390199249 12.578150190694608 0.14262087406862853 18.305236840450853 0.09707351501180307 1.0000000000001595e-14 13.99999999999993 -4.582083936474671 CK(ub)AEHDQLLLNYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CKAEHDQLLLNYAK 14 1 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 20803200.0 5056400.0 6862700.0 8884100.0 True False 6925887.724072068 6559483.222085902 6785858.553782876 1.0 0.9470963843793385 0.9797817729844944 22.72356756944416 -9.955626281896203 4.5073712749306525 1.0000007159351008 0.9634390786751236 0.6252249392607307 0.013343754044069327 18311266.96860372 0.4894332809415505 136.30032810730106 0.0045679219289287394 1.107576463209414e-10 9.955626281896203 -0.03656163725997719 CK(ub)AEHDQLLLNYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CKAEHDQLLLNYAK 14 1 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 16202900.0 6956100.0 5933500.0 3313300.0 True False 5784305.357480104 5901535.057792462 4006095.711031696 1.0 1.0202668588650425 0.6925802604544595 22.46371228449251 -6.892172422553973 1.0094101289232222 1.016700944601381 0.6631631491982909 0.9822538459936413 0.019972142580832082 0.11739948833538894 0.2116776607999126 0.015030845067071155 0.03777863216425371 1.2818215758915257e-07 6.892172422553973 -0.35353779540309016 CK(ub)DGVVFGVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CKDGVVFGVEK 11 1 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 5134000.0 1999400.0 3134600.0 0.0 True False 2621232.7622171417 2666929.8985750987 0.0 1.0 1.017433452311692 0.0 21.321814038208515 -7.010677299054405 1.1058238844380648 1.027573427185879 6.274991429745399e-21 0.9845593828648572 0.05909407385877227 0.08990923305681943 0.21442110313099796 0.04503041919761251 0.0821006335137476 9.757143694661917e-08 7.010677299054405 -1.027573427185879 down CK(ub)DGVVFGVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CKDGVVFGVEK 11 1 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 15814900.0 3888000.0 4432800.0 7494100.0 True False 3764577.5681835995 6202840.156746624 5531170.391819086 1.0 1.6476855754467774 1.4692672130243456 21.84405655520977 -10.064191330683208 4.457543006112115 0.9999630087887463 1.5584763942661468 0.9288954245694524 0.07283899159073116 23816521.927183654 0.7507448458758132 9199.967333670113 0.026283507103863818 8.625984418333634e-11 10.064191330683208 0.5585133854774005 CK(ub)DGVVFGVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CKDGVVFGVEK 11 1 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 36538300.0 12272600.0 9289500.0 14976200.0 True False 18618431.44724146 7631716.145805227 12016147.505698347 1.0 0.4099011330482384 0.6453898944037352 24.15022819905202 -10.267216195872638 5.6181597098967515 1.0000360887300859 0.5276455137259858 0.8428800533115781 0.09613788424686948 4.346056723556554e-05 5.668630661531684e-06 0.09309219668472017 0.031028368718973357 5.404851973562216e-11 10.267216195872638 -0.4723905750041001 CK(ub)DGVVFGVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CKDGVVFGVEK 11 1 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 10769200.0 1999400.0 3036300.0 5733500.0 True False 2738632.211753362 2902146.2262985986 4379365.38513908 1.0 1.0597064526749833 1.5991067973071371 21.385024099731407 -6.927905962100474 0.7637749035024478 0.991129323950005 1.7041641250575263 0.996110750963105 0.01680415310505822 0.09373918677046644 0.08311111373505889 0.015123030810945725 0.049380053948419704 1.180576238464364e-07 6.927905962100474 0.7130348011075214 CK(ub)DGVVFGVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CKDGVVFGVEK 11 1 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 10198900.0 3888000.0 3717600.0 2593300.0 True False 3233044.267604353 3697572.550914173 3135547.03993556 1.0 1.1436813866003852 0.9698435222042174 21.624461830644048 -6.687152416289585 1.8761420387168481 1.0903146757615332 0.9704570946020992 0.3573519847878357 0.0608020879374806 0.4227928160010351 2.8829623362265657 0.025945464424583044 0.0678170926851996 2.055169204738377e-07 6.687152416289585 -0.11985758115943401 CK(ub)DGVVFGVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CKDGVVFGVEK 11 1 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 34453600.0 12272600.0 18584800.0 3596200.0 True False 15887122.629112879 17550539.542647816 2941728.500128038 1.0 1.104702214011161 0.185164335216836 23.92135452114447 -6.878581442219474 1.0876469496024999 1.0637566173915984 0.12173584217738087 0.9725245406915071 0.0681302682065833 0.12889563302305623 0.2799237816866099 0.048311901264814654 0.11642416025438654 1.3225696663843957e-07 6.878581442219474 -0.9420207752142176 down CK(ub)DYLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CKDYLVK 7 1 Q14145 Q14145 KEAP1 Kelch-like ECH-associated protein 1 1 3659690.0 845690.0 1184000.0 1630000.0 True False 1108707.7796736087 1007351.8151958532 1461343.236064064 1.0 0.9085818947643773 1.3180598737155675 20.08044773611409 -6.848104546652207 1.2441943245609253 0.9512843246587067 1.3338414144641273 0.9375061674301488 0.043871989531458724 0.15955092419820704 0.47624233163308793 0.02760506768380993 0.06380756872280166 1.4187159565440103e-07 6.848104546652207 0.3825570898054206 CK(ub)DYLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CKDYLVK 7 1 Q14145 Q14145 KEAP1 Kelch-like ECH-associated protein 1 1 4030190.0 845690.0 1102900.0 2081600.0 True False 1158364.4469129236 1054170.2311974205 1589968.9518977061 1.0 0.91005057519403 1.3725981975146264 20.14365779763698 -6.856259040105999 1.2044308757603197 0.9516015455685647 1.3934548508388322 0.9489344808265878 0.0452499787785359 0.1507073462192529 0.41756620168583164 0.02934292077585765 0.06823466604987931 1.392326085780535e-07 6.856259040105999 0.44185330527026756 CK(ub)ETLDDVLHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CKETLDDVLHR 11 1 Q6F5E8-2;Q6F5E8 Q6F5E8-2 RLTPR Leucine-rich repeat-containing protein 16C 1 22063900.0 2951200.0 3507700.0 15605000.0 True False 4477186.161620122 2881723.5292148087 12520664.910085512 1.0 0.6436461262026288 2.7965477552433877 22.09416087614334 -6.864393448028046 1.1634153882091338 0.8039175667231259 2.9098584255572497 0.958756074171581 0.19134631495844445 0.14233981380740102 0.36364487919639804 0.12803480545461549 0.3004936466567814 1.366490296103847e-07 6.864393448028046 2.1059408588341237 up CK(ub)ETLDDVLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CKETLDDVLHR 11 1 Q6F5E8-2;Q6F5E8 Q6F5E8-2 RLTPR Leucine-rich repeat-containing protein 16C 1 8885300.0 2416500.0 3002400.0 3466400.0 True False 3309945.353457041 2869744.040390914 2647707.712748947 1.0 0.8670064710867921 0.7999249020783905 21.658375967943577 -13.999999999997584 0.08842287509582267 1.6858040193679784 0.6274506934916265 0.9998497425013126 0.0010191668696776911 12.178031524791168 0.08600885827095323 1.5785724731762636 0.15519172094739303 1.0000000000055627e-14 13.999999999997584 -1.058353325876352 CK(ub)ICESYNTAQAGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CKICESYNTAQAGGR 15 1 Q96PM5-7;Q96PM5-6;Q96PM5;Q96PM5-8;Q96PM5-2 Q96PM5-7 RCHY1 RING finger and CHY zinc finger domain-containing protein 1 1 22584600.0 1728100.0 11601000.0 9255500.0 True False 2621654.041032706 9530710.910973294 7426146.3681702325 1.0 3.6353808556749976 2.8326187406653283 21.322045886380014 -9.897289948903127 5.709436856322497 0.9999988696140665 3.233999798173955 0.9117074156781888 0.32772626111526626 4.716352812912146e-06 9.109967904730318e-07 0.31731974854170275 0.10577319594923355 1.266805823333327e-10 9.897289948903127 2.2340009285598885 CK(ub)LLDVTGGLGTDELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CKLLDVTGGLGTDELR 16 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-4 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 14138900.0 3723200.0 4006500.0 6409200.0 True False 4881151.255520086 3408745.8172146785 5746037.465387605 1.0 0.6983487375769668 1.177188979523923 22.218790027510945 -6.73640493431359 1.699836031999763 0.8197848222935649 1.177260225540027 0.5888226070842706 0.12675514217683367 0.32430113857829573 1.8384521045543853 0.05902640996302042 0.14542231537926514 1.834826760928256e-07 6.73640493431359 0.3574754032464622 CK(ub)LLDVTGGLGTDELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CKLLDVTGGLGTDELR 16 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-4 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 51203700.0 9284700.0 16155000.0 25764000.0 True False 12019227.17879868 15255960.048613692 21075216.360964015 1.0 1.26929625521385 1.7534585250322625 23.518840799764906 -6.962073642915827 0.4051509530190092 0.9748508976272572 2.0657305667089005 0.9998395431723186 0.0039488477763546855 0.07896852464399205 0.018454275367930078 0.006229048471520085 0.04048971655349992 1.0912552776053963e-07 6.962073642915827 1.0908796690816434 CKDDEFTHLYTLIVRPDNTYEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CKDDEFTHLYTLIVRPDNTYEVK 23 2 P27797;K7EJB9 P27797 CALR Calreticulin 0 57398700.0 13413000.0 29435200.0 14550500.0 False True 17584572.89167676 25043582.89751092 13044953.838251658 1.0 1.424179196832509 0.7418408123194267 24.067806958256757 -6.738617551682725 1.6921731947496028 1.2527920987964876 0.7415920942412701 0.5985654451045671 0.17822755849506475 0.3203114480321263 1.800457751123498 0.08334807985164548 0.20480708807729114 1.8255025683928464e-07 6.738617551682725 -0.5112000045552174 CKDDEFTHLYTLIVRPDNTYEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CKDDEFTHLYTLIVRPDNTYEVK 23 2 P27797;K7EJB9 P27797 CALR Calreticulin 0 70914800.0 37013400.0 13504100.0 20397300.0 False True 35838429.87711081 18896357.552951198 15054635.224116486 1.0 0.5272652183074535 0.42006960895715856 25.09500409686024 -13.999999999999998 0.20849631987696082 3.7172381480726364 0.3560033773977178 0.9994892223859416 0.0056940611436697664 12.71191428765608 0.14473782831722073 14.139643450313947 0.06417298022718912 1.0000000000000041e-14 13.999999999999998 -3.3612347706749186 CKDDEFTHLYTLIVRPDNTYEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CKDDEFTHLYTLIVRPDNTYEVK 23 2 P27797;K7EJB9 P27797 CALR Calreticulin 0 175800500.0 12255000.0 136971000.0 26574500.0 False True 18591730.96050914 112527454.89069241 21322038.426982865 1.0 6.052553962281025 1.1468560120772613 24.148157761090086 -6.639273625395074 2.046634451845881 4.3058470887238816 1.167059849978893 0.15194749904645177 2.162219870354606 0.5352402308054722 4.283823789338401 0.8605101716168277 2.3949335291657814 2.2947024250432157e-07 6.639273625395074 -3.138787238744989 CKDDEFTHLYTLIVRPDNTYEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CKDDEFTHLYTLIVRPDNTYEVK 23 2 P27797;K7EJB9 P27797 CALR Calreticulin 0 104565700.0 13413000.0 31641700.0 59511000.0 False True 18372148.57269573 30243665.068890557 45455727.467517555 1.0 1.6461691973163122 2.474165026896899 24.131017019779648 -6.967742555392239 0.30736424842329185 0.8684041970038466 3.2781495307916044 0.9999590337113408 0.00386172812125161 0.07704222979060824 0.011638588172877322 0.013259598841816593 0.0737004628525808 1.0771035185869766e-07 6.967742555392239 2.409745333787758 CKDDEFTHLYTLIVRPDNTYEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CKDDEFTHLYTLIVRPDNTYEVK 23 2 P27797;K7EJB9 P27797 CALR Calreticulin 0 57941100.0 37013400.0 5724700.0 15203000.0 False True 30778282.071642734 5693859.904836023 18381877.00927016 1.0 0.1849960271201103 0.597235315684046 24.875409372294516 -10.564194255776783 5.505309806095892 1.0024282263027349 0.3911156714571338 0.744165126012829 0.16829598481826777 0.005031082616924982 0.0003982648635455279 0.16344604751227268 0.054317295536226995 2.7277574100424577e-11 10.564194255776783 -0.6113125548456011 CKDDEFTHLYTLIVRPDNTYEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CKDDEFTHLYTLIVRPDNTYEVK 23 2 P27797;K7EJB9 P27797 CALR Calreticulin 0 60085200.0 12255000.0 30992200.0 16838000.0 False True 15864339.082165038 29267456.825666692 13773656.772469806 1.0 1.8448582493152625 0.868214975810394 23.919284083182536 -6.677841323764807 1.9091007946853726 1.5355581358310926 0.8719439953593188 0.31453376108194275 0.3582364550049843 0.44329690297037755 3.121707307306946 0.15065812586097954 0.3985195127880127 2.0997069040273283e-07 6.677841323764807 -0.6636141404717738 CKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIK 36 3 H3BQQ9;B0QYN7;P63279 H3BQQ9 UBE2I SUMO-conjugating enzyme UBC9 0 170276000.0 31508000.0 54518000.0 84250000.0 False True 47799939.543347344 44788836.948921755 67597950.57191312 1.0 0.937006142200348 1.4141848549957259 25.510505457719482 -6.873653870299743 1.1145388536862457 0.9634473759353849 1.4441479532979957 0.968198032469662 0.03774635919989486 0.13340207053661182 0.3074965600337312 0.02622017916196765 0.06250481803506792 1.337661198548838e-07 6.873653870299743 0.48070057736261085 CKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CKFEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIK 36 3 H3BQQ9;B0QYN7;P63279 H3BQQ9 UBE2I SUMO-conjugating enzyme UBC9 0 98326000.0 31508000.0 28528000.0 38290000.0 False True 40787727.115532905 26940391.721872576 31321612.888577558 1.0 0.66050240175342 0.7679175846170052 25.28163177981193 -10.637710062998458 9.58252399224061 1.0000964706101514 0.7142099931852127 0.9042004924148829 0.043852064773921895 9.040901969546197e-05 3.4180871349354493e-06 0.04247371946843508 0.01415319304718403 2.3029787835788516e-11 10.637710062998458 -0.28588647742493867 CLAFHDISPQAPTHFLVIPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CLAFHDISPQAPTHFLVIPK 20 0 P49773;D6REP8;D6RE99;D6RD60 P49773 HINT1 Histidine triad nucleotide-binding protein 1 0 51652400.0 8095800.0 27030600.0 16526000.0 False True 10613672.199838713 22997739.844453532 14816048.048585728 1.0 2.1668032902696024 1.3959398565946737 23.33942056154742 -10.099601487791901 4.805086442504856 0.9999631575048202 1.7813715734396895 0.5780469933628327 0.3147036790048969 219052313.93082708 2.3476419296001665 89295.368285688 0.10773143994660697 7.950574513978145e-11 10.099601487791901 0.7814084159348693 CLAFHDISPQAPTHFLVIPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CLAFHDISPQAPTHFLVIPK 20 0 P49773;D6REP8;D6RE99;D6RD60 P49773 HINT1 Histidine triad nucleotide-binding protein 1 0 37155300.0 20427600.0 6944500.0 9783200.0 False True 19779137.019502904 9717475.065089079 7220686.43029108 1.0 0.4912992440219872 0.36506579752044976 24.23747614567541 -13.999999999999995 0.19573485857313475 3.7831535828934832 0.27955065826326925 0.9994872637811432 0.0062143147773872955 12.449765820076776 0.14029710850091598 13.242636663412165 0.08301212783889989 1.0000000000000123e-14 13.999999999999995 -3.503602924630214 CLAFHDISPQAPTHFLVIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CLAFHDISPQAPTHFLVIPK 20 0 P49773;D6REP8;D6RE99;D6RD60 P49773 HINT1 Histidine triad nucleotide-binding protein 1 0 58168000.0 8095800.0 20774000.0 29298200.0 False True 11089036.040768659 19856135.989568587 22378568.57536962 1.0 1.7906097443067035 2.0180806062037475 23.402630623070312 -10.789474415060818 0.24968732902420065 4.5902061648157465e-23 2.1316185890432653 0.999202450548973 0.012321783296500471 2.60166849488413 0.1291809228162144 1.6511349161044502 0.10396112967451764 1.6237740066264758e-11 10.789474415060818 2.1316185890432653 CLAFHDISPQAPTHFLVIPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CLAFHDISPQAPTHFLVIPK 20 0 P49773;D6REP8;D6RE99;D6RD60 P49773 HINT1 Histidine triad nucleotide-binding protein 1 0 39652700.0 20427600.0 5726100.0 13499000.0 False True 16986454.49612003 5695252.362758144 16321578.487676006 1.0 0.3352819956665488 0.9608584588034018 24.017881421109685 -10.85021261764653 10.391009689468758 1.0097726842615815 0.6480702272349802 0.2967543089346709 0.25539052163005005 0.056346753607092986 0.0008122421106136988 0.24097988838271794 0.08242693642103406 1.4118461775516355e-11 10.85021261764653 -0.3617024570266013 CLATEK(ub)VK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CLATEKVK 8 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 29925800.0 6844800.0 11206000.0 11875000.0 True False 8973599.085137498 9534108.480645888 10646288.913043411 1.0 1.0624620500860944 1.1864012211863022 23.097255299270643 -6.960199410937087 0.4326150502895095 0.9952113374104972 1.2584253690345402 0.9997775163252783 0.0011554490717686433 0.07962997093220517 0.020868746323631494 0.001620356253186963 0.010284692565931734 1.0959748520674482e-07 6.960199410937087 0.263214031624043 CLATEK(ub)VK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CLATEKVK 8 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 17673700.0 7732700.0 6221500.0 3719500.0 True False 7487229.671165982 8705777.39469389 2745251.367391825 1.0 1.1627501461883356 0.3666578277896354 22.83600057919772 -6.853436068087465 1.218294648046244 1.0871807077530593 0.33264200939666916 0.945168641296437 0.08041318142917155 0.1537191196772055 0.4373099686341672 0.05159733836984084 0.11969919249748777 1.401405868848604e-07 6.853436068087465 -0.7545386983563902 down CLATEK(ub)VK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CLATEKVK 8 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 31971900.0 10072000.0 9779900.0 12120000.0 True False 15279960.36183174 8034600.434292536 9724476.687615288 1.0 0.5258259998083764 0.6364202823396286 23.8651374650549 -9.861992056167916 6.543603229711833 1.0000000149766248 0.5811231410739968 0.9503154158153548 0.04514992677857306 9.87505160536365e-09 1.6923679428961677e-09 0.04371622992676775 0.014572076207974962 1.374067108324147e-10 9.861992056167916 -0.41887687390262807 CLATEK(ub)VK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CLATEKVK 8 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 27206000.0 6844800.0 7399200.0 12962000.0 True False 9375507.533764847 7072278.878117656 9900642.560769629 1.0 0.7543355762498863 1.0560113705965855 23.160465360793534 -6.6901862332920485 1.8659044264165767 0.8460074121189924 1.054966034363276 0.371194659339496 0.10389538901457114 0.41628793169648487 2.810216271786389 0.04454310570340935 0.11595969468272257 2.0408625983788418e-07 6.6901862332920485 0.20895862224428363 CLATEK(ub)VK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CLATEKVK 8 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 18262000.0 7732700.0 4646300.0 5883000.0 True False 6430082.666693467 4621269.459681663 7113108.100081335 1.0 0.7186951862405919 1.1062234295875857 22.616405854631996 -6.7119881237398635 1.7878460559479012 0.82741697227058 1.105378866286966 0.47468300071737357 0.1185036774623619 0.37108372064532547 2.313304711377439 0.052720124956322535 0.13362561614897528 1.940938953976916e-07 6.7119881237398635 0.27796189401638594 CLATEK(ub)VK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CLATEKVK 8 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 23734900.0 10072000.0 9525800.0 4137100.0 True False 13038402.54880181 8995680.85614882 3384190.250230717 1.0 0.6899373464255786 0.25955558877430995 23.63626378714735 -7.2040905709870104 0.3798536905211191 1.0353845925938485 3.5782715679965885e-12 0.99975027469824 0.0047978943486547375 0.08933229534697826 0.023473823807144346 0.008930487653643744 0.043521620612840387 6.250423282272797e-08 7.2040905709870104 -1.0353845925902703 down CLEELQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 CLEELQKR 8 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 12984070.0 5005550.0 4084800.0 3893720.0 True False 6562324.523815158 3475363.7624256886 3490835.2055996186 1.0 0.5295934009074587 0.5319510171938497 22.64577550992266 -9.866954035867547 6.467741044414837 1.0000000220361565 0.5307722090506156 0.9999810657781901 0.000962492818650096 3.05407651927981e-10 5.367730120522234e-11 0.0009319297059581307 0.0003106432214325766 1.358457213099893e-10 9.866954035867547 -0.46922781298554084 CLEELQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 CLEELQKR 8 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 60756280.0 4409280.0 16398000.0 39949000.0 True False 6689200.121546617 13471648.78184121 32053062.63973132 1.0 2.0139401628077493 4.791763149152174 22.67340227650326 -6.953472024678883 0.5193309601730574 0.9525523001405842 5.976973924803359 0.9994463352985555 0.03771493660575947 0.08212081138508782 0.03041897586767138 0.04277184158644297 0.22943467792234667 1.1130840904246371e-07 6.953472024678883 5.024421624662775 CLEELQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CLEELQKR 8 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 13665450.0 5005550.0 2878800.0 5781100.0 True False 6856237.1049024975 2751605.097081454 4415723.245491854 1.0 0.40132875438539617 0.6440447111046417 22.708985571445552 -10.296185053166548 5.698945768526453 1.0000465372046496 0.5226867327450273 0.8375681895095243 0.09908837439894895 5.85950698971514e-05 7.236503132836799e-06 0.09595122290417542 0.0319806353208222 5.056091756921124e-11 10.296185053166548 -0.47735980445962234 CLEELQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CLEELQKR 8 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 27426780.0 4409280.0 16074300.0 6943200.0 True False 5707899.87990279 15179751.074554667 5679608.843248149 1.0 2.6594284051830965 0.9950435296256243 22.44452859859571 -6.64684660445144 2.01964998081925 2.079468728909127 1.0020080778855327 0.18142500124611272 0.7088119860269174 0.5162971219112332 4.032913813857117 0.2849767576935188 0.7850733520571259 2.2550355642816532e-07 6.64684660445144 -1.0774606510235945 CLELFSELAEDKENYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CLELFSELAEDKENYK 16 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 32508400.0 4669400.0 13240000.0 14599000.0 False True 6121628.618533925 11264643.609115789 13088435.523496484 1.0 1.8401383538705374 2.1380642863354633 22.545484092717096 -10.450235244770505 0.22526750918625307 4.609992118272862e-18 2.3343759528810843 0.9992548221860212 0.013154041861507582 2.1095229330253575 0.11224487133018936 1.3536336617551898 0.1554053467000044 3.546212491171786e-11 10.450235244770505 2.3343759528810843 CLELFSELAEDKENYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CLELFSELAEDKENYK 16 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 14781400.0 6977500.0 4116500.0 3687400.0 False True 6756003.081790396 5760239.917263914 2721559.32037118 1.0 0.8526106112635762 0.4028357132794475 22.68773855555742 -6.951066448227892 0.5470093807621978 1.0063333889311739 0.2280912198741106 0.999282345056311 0.006804320667344663 0.08306029673953254 0.03421166405656952 0.007413956037121736 0.03729207531657245 1.1192666195518727e-07 6.951066448227892 -0.7782421690570632 down CLELFSELAEDKENYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CLELFSELAEDKENYK 16 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 28962400.0 4669400.0 13564000.0 10729000.0 False True 6395803.365790315 12964697.629850233 8195031.170691052 1.0 2.027063198846204 1.2813138087584734 22.608694154239988 -10.059178377224335 4.462524846244115 0.9999615183715286 1.6541885035430424 0.5064231323314223 0.3044509137953166 44968050.71257351 33788176.25166723 16108.600381960352 0.10422164783935692 8.726128875841641e-11 10.059178377224335 0.6542269851715138 CLELFSELAEDKENYKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CLELFSELAEDKENYKK 17 2 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 65541600.0 7114900.0 18573700.0 39853000.0 False True 9327702.800789615 15802576.359715527 35729393.85697009 1.0 1.6941552166925598 3.8304601486601286 23.153090391454178 -6.950875334979129 0.5491489568478412 0.970305423762717 4.654524185829116 0.9992682033499811 0.03258353691402263 0.08313612747020045 0.03452223402788854 0.03540418892902069 0.17719632062101637 1.119759266272048e-07 6.950875334979129 3.684218762066399 CLELFSELAEDKENYKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CLELFSELAEDKENYKK 17 2 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 13527600.0 6037700.0 3725100.0 3764800.0 False True 5846036.518369891 5212551.856139876 2778685.938420953 1.0 0.8916386067313422 0.4753110812239268 22.479027410563006 -6.945801224157627 0.6031844364632875 1.004658441752181 0.34086249335296565 0.998829204992751 0.007738774904801181 0.08521690997821478 0.0432872667097859 0.007917897530118173 0.03502386141588274 1.1329187795771855e-07 6.945801224157627 -0.6637959483992155 down CLELFSELAEDKENYKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CLELFSELAEDKENYKK 17 2 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 122301700.0 2934600.0 113488000.0 5879100.0 False True 4452002.7479975615 93235179.7142089 4717093.3080989355 1.0 20.942300576104667 1.0595441142125546 22.086023052507468 -10.091826919133968 3.024831728177401e-10 8.174242553314244 11.827404204993087 0.0 9.672593923982882 964548546.4436346 1.0211256428729145 615280808.7278044 615280809.204433 8.094184151982517e-11 10.091826919133968 3.653161651678843 CLELFSELAEDKENYKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CLELFSELAEDKENYKK 17 2 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 38702400.0 7114900.0 16062000.0 15525500.0 False True 9745470.802942889 15352327.730068872 11858696.65770939 1.0 1.5753295084966907 1.2168418435083055 23.21630045297707 -10.199074006319266 4.613233508422896 0.99993309677439 1.3960856759983664 0.6194359106796894 0.14635197658985744 102872933.15558031 13.019964460390806 87385.37825100684 0.050100174288296384 6.32304093880212e-11 10.199074006319266 0.3961525792239764 CLELFTELAEDKENYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CLELFTELAEDKENYK 16 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 12470300.0 3193500.0 4393500.0 4883300.0 False True 4186709.4258979885 3738006.925728869 4378022.959921259 1.0 0.892826930526023 1.0456954411117836 21.99738536216641 -6.718235828707301 1.765479420526073 0.9346761061422314 1.0454370586960793 0.5042845276276944 0.04510873002952363 0.35874516994731087 2.1842830317553803 0.020294212743216796 0.05105561077710907 1.9132167362386272e-07 6.718235828707301 0.11076095255384788 CLELFTELAEDKENYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CLELFTELAEDKENYK 16 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 10870900.0 3193500.0 4494200.0 3183200.0 False True 4374223.251092507 4295631.383668013 2431393.7200618642 1.0 0.982032954672612 0.5558458223307644 22.0605954236893 -6.915755443622907 0.8556067426829307 1.0109173111515501 0.4934065832989019 0.9929184985306532 0.017274020776258427 0.10073423757229315 0.11902881823582832 0.014557977326196616 0.041985918869277876 1.2140723165433953e-07 6.915755443622907 -0.5175107278526483 CLELFTELAEDKENYKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CLELFTELAEDKENYKK 17 2 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 10410500.0 2022400.0 4349600.0 4038500.0 False True 2651385.9849494593 3700656.6346080075 3620634.7600274426 1.0 1.3957442091097685 1.365563060444577 21.3383152802827 -10.276329548251242 5.164952087873611 0.9999303733973101 1.3806536347771794 0.9953072212325033 0.012321402347072337 9.881301964876436e-06 1.3844632287258059e-06 0.011932320409190032 0.003976715507638528 5.2926168089343186e-11 10.276329548251242 0.38072326137986934 CLELFTELAEDKENYKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CLELFTELAEDKENYKK 17 2 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 55565000.0 3061300.0 44327000.0 8176700.0 False True 4644215.911008288 36416500.52156821 6560571.661025079 1.0 7.8412591531865194 1.4126327859724201 22.147003614417425 -6.6314861418809485 2.0749620487122806 5.502177149376348 1.4385386443702979 0.12294166195057421 2.9334193229099044 0.5551020926567776 4.556420933416762 1.1554703340109138 3.249509847534855 2.3362206486584777e-07 6.6314861418809485 -4.06363850500605 CLELFTELAEDKENYKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CLELFTELAEDKENYKK 17 2 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 13501600.0 2022400.0 4840700.0 6638500.0 False True 2770135.9333049916 4626821.867945739 5070623.024199138 1.0 1.6702508394328412 1.8304600013435022 21.40152534180559 -11.181998172254014 0.26428101897460793 1.2053204299288432e-08 1.8967745359204997 0.9992581955906323 0.009797282043040229 3.282168106407552 0.14157011902927633 2.0145447831386636 0.0681206186611813 6.576606051409946e-12 11.181998172254014 1.8967745238672955 CLFLTESLK(ub)QFTEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CLFLTESLKQFTEK 14 1 P14373;P14373-2 P14373 TRIM27 Zinc finger protein RFP 1 21707700.0 2830400.0 6610300.0 12267000.0 True False 4293923.729957169 5430640.318490364 9842422.073182903 1.0 1.2647267767246841 2.292174405547972 22.03386513513898 -6.9455679109877515 0.6055509306936611 0.9885540379936542 2.621446341934659 0.9988059692621835 0.019258029417529667 0.08531577751489663 0.04371474476016612 0.01965868860956392 0.08650382277669082 1.133527573600975e-07 6.9455679109877515 1.6328923039410048 up CLFLTESLK(ub)QFTEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CLFLTESLKQFTEK 14 1 P14373;P14373-2 P14373 TRIM27 Zinc finger protein RFP 1 15610000.0 2830400.0 5639900.0 7139700.0 True False 3664008.5955250883 5326034.607129451 5840347.859508415 1.0 1.4536086551855314 1.5939776633278984 21.80499145723143 -11.786608674121913 0.20108386237790699 6.548957893534177e-18 1.6958138942042376 0.9993946998521668 0.006236352900431658 4.726416078219588 0.12310700685731378 2.0922857346806394 0.08790446418732727 1.6345240906791006e-12 11.786608674121913 1.6958138942042376 CLFQLETVAVTQMNK ddPTM_RPMI8226_Bortezomib_1h_R1 2 CLFQLETVAVTQMNK 15 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 14216400.0 4082000.0 6603800.0 3530600.0 False True 5351541.530144236 5618538.781410787 3165287.3799066213 1.0 1.049891652669162 0.5914720762376873 22.35152309402568 -6.879932194633687 1.0801419740466203 1.0308967054711455 0.5590217836809042 0.9736322318025609 0.03334571648572813 0.12769178361782 0.27262965883666634 0.023781956268682368 0.05750266271450513 1.318462570918698e-07 6.879932194633687 -0.4718749217902414 CLFQLETVAVTQMNK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 CLFQLETVAVTQMNK 15 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 16651800.0 4082000.0 5535100.0 7034700.0 False True 5591225.711902189 5290540.979872015 5373248.744194267 1.0 0.9462220365401993 0.9610144574839988 22.41473315554857 -10.426499295259735 5.9158158810385375 1.0000187767980608 0.9536182476614695 0.9291209164025049 0.006038980562128107 1.4961604841164708e-06 1.450445351284383e-07 0.005849584608801774 0.0019490725954327043 3.745421548143123e-11 10.426499295259735 -0.04640052913659132 CLFQLETVAVTQMNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CLFQLETVAVTQMNK 15 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 25001200.0 6010600.0 10574000.0 8416600.0 False True 7780840.186639015 9985547.604706971 6884865.1616088245 1.0 1.2833508162593805 0.8848485506014213 22.891494517292866 -6.715776664597453 1.7748607264094483 1.1731618635920318 0.885625857772008 0.49239901461964364 0.11930070280439176 0.363567164925336 2.2359502471359467 0.053424188246379914 0.1347678055838964 1.9240809307898636e-07 6.715776664597453 -0.2875360058200238 CLFTLLGHLDYIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CLFTLLGHLDYIR 13 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ITV3;A0A3B3ISK1;A0A3B3ITX2 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 15550700.0 4832900.0 4452800.0 6265000.0 False True 7331862.632316975 3658163.0501148063 5026720.003952955 1.0 0.4989404785068612 0.6855993157586531 22.80574832553318 -10.081887305665264 5.101292269939146 1.0000084491220997 0.5922698971316106 0.8641655918194149 0.07620315121200663 7.322763129992315e-06 1.3179924962265216e-06 0.0737849125079026 0.02459446129714627 8.281570328897562e-11 10.081887305665264 -0.40773855199048914 CLGSLFSMLHQACR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CLGSLFSMLHQACR 14 0 Q14204;A0A2R8YFZ7;A0A2R8YGC7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 8025400.0 1449900.0 3905900.0 2669600.0 False True 1900832.9408515731 3323154.9450789494 2393375.4006114285 1.0 1.7482624978027665 1.2591192782776568 20.85820031225448 -10.290944349781817 4.663309603960724 0.9997513330480746 1.5036908880414575 0.5857193090555342 0.19969188316738118 141630708.73550418 153.53199423559857 378168.831369755 0.0683598431002581 5.117474063256845e-11 10.290944349781817 0.5039395549933828 CLGSLFSMLHQACR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CLGSLFSMLHQACR 14 0 Q14204;A0A2R8YFZ7;A0A2R8YGC7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 12998100.0 1449900.0 4703000.0 6845200.0 False True 1985967.2120742227 4495205.909258739 5228504.741319261 1.0 2.263484453282473 2.6327246036748027 20.92141037377737 -10.143564879336438 0.2881184194616994 2.1349184808447017e-11 2.7737501693206665 0.9989741774089849 0.022390726726221055 1.5974683108521892 0.1327384591715481 1.4020062617057447 0.13850106473049623 7.185138114454564e-11 10.143564879336438 2.7737501692993174 CLHLTK(ub)DFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CLHLTKDFR 9 1 Q8WUA4;A0A087WZD8;Q8WUA4-2 Q8WUA4 GTF3C2 General transcription factor 3C polypeptide 2 1 6818700.0 2064600.0 2706200.0 2047900.0 True False 2827938.4137171106 2586631.135793326 1564228.1978244218 1.0 0.9146702499766943 0.5531337564626673 21.431319271086625 -6.943554443925674 0.6256212030483722 1.0039460656661705 0.4445187820080913 0.9985933929111447 0.007264691749757308 0.08618181487876138 0.0475015259267961 0.007279029588428749 0.030663082099148233 1.1387950115667165e-07 6.943554443925674 -0.5594272836580791 CLICK(ub)EQVQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CLICKEQVQSR 11 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 11807100.0 3325500.0 3724900.0 4756700.0 True False 4359762.704187809 3169159.439546481 4264522.313488309 1.0 0.72691099368833 0.9781546847474026 22.055818182581422 -10.424777753109558 7.9379731213996525 1.0000040049453298 0.8525328393464384 0.3147610987584625 0.10256980736469734 7.2700406965141965e-06 5.268796237399651e-07 0.09931548480213835 0.033104262978931306 3.760297854356359e-11 10.424777753109558 -0.1474711655988914 CLICK(ub)EQVQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CLICKEQVQSR 11 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 9843600.0 4054300.0 3542000.0 2247300.0 True False 3925598.4657116192 4956339.071285992 1658664.7124451264 1.0 1.2625690361807098 0.42252531096413326 21.904481181977385 -6.822711141687244 1.3600712244505309 1.1411493306654448 0.4030930840746344 0.8905102525623729 0.11610570842471696 0.18998313448759557 0.6897827879602499 0.06707024366635848 0.15448817468576914 1.504142069702582e-07 6.822711141687244 -0.7380562465908104 down CLICK(ub)EQVQSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CLICKEQVQSR 11 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 29995500.0 4966500.0 11705000.0 13324000.0 True False 7534543.599785273 9616151.298417576 10690505.55988335 1.0 1.2762752210620463 1.4188657107496225 22.845088693454038 -12.235204379930394 0.10021098136276815 3.8352896543201346e-13 1.7525784538003473 0.9998451598242006 0.0021636654223466884 6.285572151043601 0.07636568661165015 1.57336673330237 0.25635580551392323 5.818293431750478e-13 12.235204379930394 1.7525784537999638 CLICK(ub)EQVQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CLICKEQVQSR 11 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 11136100.0 3325500.0 3528900.0 4281700.0 True False 4555027.21825838 3372981.5294882376 3270450.6443795245 1.0 0.7404964598165236 0.717987069598672 22.119028244104314 -13.999999999999998 0.3461858259107736 4.117259512466657 0.7147183700567341 0.9997473735830338 0.0020339287319429676 20.28646786767988 0.1891430626415578 46.418582973046156 0.006804823446991413 1.0000000000000041e-14 13.999999999999998 -3.4025411424099232 CLICK(ub)EQVQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CLICKEQVQSR 11 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 11742100.0 4054300.0 2583700.0 5104100.0 True False 3371330.085943502 2569781.095275705 6171343.711308027 1.0 0.762245472785417 1.830536777469214 21.68488645741166 -6.848300076153787 1.2432181467556644 0.8732846976940338 1.8718744104236549 0.9378035881826525 0.11421216194806456 0.1593348297447018 0.4747491897317995 0.07191638569205482 0.16625297738175707 1.4180773613082095e-07 6.848300076153787 0.998589712729621 CLK(ub)DEDPYVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CLKDEDPYVR 10 1 P63010;P63010-2;P63010-3;A0A087WU93;A0A087WZQ6;K7ERB2;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 1 46372000.0 15197000.0 20395000.0 10780000.0 True False 23054960.049519155 16755352.903137682 8649328.27495815 1.0 0.7267569697431395 0.3751612779367425 24.458573830008632 -6.967680089504469 0.30861177414046315 1.0550619155983927 0.035702556995304426 0.9999582136767243 0.0016532629504534312 0.07706288890617943 0.011710887161399449 0.005598198128583467 0.03125726688369402 1.077258452783121e-07 6.967680089504469 -1.0193593586030882 down CLK(ub)DEDPYVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CLKDEDPYVR 10 1 P63010;P63010-2;P63010-3;A0A087WU93;A0A087WZQ6;K7ERB2;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 1 20129900.0 8530800.0 6311500.0 5287600.0 True False 11684867.296201646 6032637.060660556 4038777.7815403123 1.0 0.5162777554710922 0.34564173294917794 23.478138013890774 -13.999999999999998 0.14520246421915714 3.3234589140672486 0.14714388958185617 0.9995830319891602 0.005659259218530452 11.942950331738482 0.11974072137187647 7.84246617615583 0.17814769208157857 1.0000000000000041e-14 13.999999999999998 -3.1763150244853926 CLK(ub)DEDPYVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CLKDEDPYVR 10 1 P63010;P63010-2;P63010-3;A0A087WU93;A0A087WZQ6;K7ERB2;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 1 13935400.0 4851300.0 4054900.0 5029200.0 True False 4034070.899030093 4033055.4488653727 6080782.467606495 1.0 0.9997482815274852 1.507356370228518 21.943805008946907 -6.906782495406034 0.9173686754317494 0.9826396098580966 1.5686340530308014 0.989649531382631 0.024338545273596152 0.10658454565593221 0.15059407772786718 0.01961453022450235 0.053010643233699514 1.2394171595353147e-07 6.906782495406034 0.5859944431727048 CLK(ub)DEDPYVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CLKDEDPYVR 10 1 P63010;P63010-2;P63010-3;A0A087WU93;A0A087WZQ6;K7ERB2;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 1 39582500.0 15197000.0 19929000.0 4456500.0 True False 19672816.07765499 18819933.631001037 3645462.7275514696 1.0 0.9566466517407904 0.18530457018261365 24.22970015210108 -6.91847693567321 0.8359501808404547 1.0179715370580453 0.065176333112421 0.9937471317916629 0.029593955965354357 0.09907635848242315 0.11032092414859207 0.025294635128401487 0.07470001744193869 1.206488160156141e-07 6.91847693567321 -0.9527952039456243 down CLLVSGFDSQSER ddPTM_RPMI8226_Bortezomib_1h_R1 1 CLLVSGFDSQSER 13 0 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 0 7226700.0 2051600.0 1809600.0 3365500.0 False True 2689667.4677226613 1539614.7337655525 3017270.3441555914 1.0 0.5724182458395657 1.1218005126523358 21.358996388082915 -6.699030866455498 1.834581073070418 0.7342277756399569 1.1201211716809176 0.4128103686783212 0.1805211234503924 0.3975700781636628 2.6008341108704154 0.07852533918477253 0.20216922163408907 1.999719739220279e-07 6.699030866455498 0.38589339604096073 CLLVSGFDSQSER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CLLVSGFDSQSER 13 0 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 0 3965000.0 2051600.0 0.0 1913400.0 False True 2810131.962405321 0.0 1461494.3277099705 1.0 0.0 0.5200803190961218 21.422206449605806 -10.717840131437539 6.593475904046611 1.0102045499449097 0.2600401595480619 0.7296618022841012 0.21232190117489214 0.03153103260540756 0.0013493312448511594 0.2035231010747093 0.0685265989404545 1.9149607133362985e-11 10.717840131437539 -0.7501643903968478 CLMNFK(ub)LGNFSYQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CLMNFKLGNFSYQK 14 1 Q96PZ0;Q96PZ0-2;E7EUH7 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 1 6831100.0 1712700.0 2281600.0 2836800.0 True False 2345931.473977183 2180791.3677577605 2166806.265729926 1.0 0.929605741663267 0.9236443134702582 21.16172944134482 -13.99999999997242 0.34968527357116924 1.8640124671155034 0.9228172569579466 0.9997540817922407 0.0005437320565100549 20.628595272624615 0.1903360780940908 13.237353806406112 0.001780581412786754 1.0000000000635047e-14 13.99999999997242 -0.9411952101575568 CLMNFK(ub)LGNFSYQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CLMNFKLGNFSYQK 14 1 Q96PZ0;Q96PZ0-2;E7EUH7 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 1 18599300.0 6840700.0 6241700.0 5516900.0 True False 8855421.000356281 5894343.908104736 4512880.808174294 1.0 0.6656198398548854 0.5096178722607008 23.078129465876543 -13.99999999998324 0.1018920137703568 2.642585231368895 0.1868851985857033 0.9997842062928802 0.0030050367805041383 12.066317770591386 0.09543925117303653 4.148141986420695 0.28753968249412226 1.0000000000385912e-14 13.99999999998324 -2.455700032783192 CLSAAEEK(ub)YSQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CLSAAEEKYSQK 12 1 J3KN67;A0A2R2Y2Q3;P06753-2;P06753-3;P06753-6 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 1 11428100.0 5947500.0 3712000.0 1768600.0 True False 7797230.09567193 3158184.06926267 1585602.2376091457 1.0 0.40503922938168874 0.20335455259801533 22.894530278305457 -13.555240123831066 0.1579590874011958 3.531991958170494 5.280454931899093e-19 0.9995414239949956 0.007241942049320966 10.229866354427747 0.12232157445714288 8.060441061386312 0.18231792034230623 2.7845811325483236e-14 13.555240123831066 -3.531991958170494 CLSAAEEK(ub)YSQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CLSAAEEKYSQK 12 1 J3KN67;A0A2R2Y2Q3;P06753-2;P06753-3;P06753-6 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 1 12130500.0 5947500.0 3510800.0 2672200.0 True False 8146451.475144107 3355681.247336934 2041081.395686518 1.0 0.41191938079733953 0.25054852433775926 22.957740339828348 -13.999999999999936 0.18145522610314424 4.065042593738154 0.12427082374078498 0.9994964554553988 0.00722716461493812 12.223910660361204 0.13504947824874455 13.214120900419427 0.1190115740781982 1.0000000000001472e-14 13.999999999999936 -3.940771769997369 CLSAAEEK(ub)YSQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CLSAAEEKYSQK 12 1 J3KN67;A0A2R2Y2Q3;P06753-2;P06753-3;P06753-6 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 1 9244100.0 3433400.0 3001800.0 2808900.0 True False 2855024.225409671 2985628.707589354 3396228.0031137927 1.0 1.0457454900092633 1.1895618863361705 21.445071556499023 -6.950393876020044 0.5545095299797486 0.9980621827016778 1.244053864388585 0.9992317803638682 0.0022385883961496393 0.08332809578463707 0.03531178175128119 0.0024158721875984905 0.01194127572085141 1.1210013199866152e-07 6.950393876020044 0.24599168168690722 CLSAAEEK(ub)YSQKEDKYEEEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CLSAAEEKYSQKEDKYEEEIK 21 3 J3KN67;A0A2R2Y2Q3;P06753-2;P06753-3;P06753-6 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 1 62977900.0 17728900.0 32740000.0 12509000.0 True False 26896037.456203204 26897291.20121245 10036590.667110542 1.0 1.0000466144877769 0.3731624289806207 24.680890303038684 -6.906874037169162 0.916735099605526 1.021380512604878 0.297333740884959 0.9896879750878897 0.030007988149775882 0.10652259229055026 0.1502396468289661 0.024194317792488092 0.06542755708292508 1.2391559393723493e-07 6.906874037169162 -0.724046771719919 down CLSSATDPQTK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 CLSSATDPQTKR 12 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;O94979-7;H7BXG7;H0Y8W8 D6REX3 SEC31A Protein transport protein Sec31A 1 8767300.0 1795900.0 1968800.0 5002600.0 True False 2724511.5978766526 1617452.257695391 4013833.917282533 1.0 0.5936668645330605 1.4732306224758644 21.377566201608964 -6.781080763865155 1.5315735120036533 0.7702481253805074 1.4804465866608754 0.7712263238254883 0.1719147094375751 0.2488975152631094 1.1532551353085008 0.08840043915768461 0.20840780769996933 1.6554620757248244e-07 6.781080763865155 0.710198461280368 CLTGLAVGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CLTGLAVGLR 10 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 13556800.0 5818400.0 3640800.0 4097600.0 False True 7969619.716347788 3479937.4174844264 3129831.272721002 1.0 0.4366503724570645 0.39272027827135764 22.926079454590305 -13.999999999999998 0.36175676414135194 8.452174387364554 0.3875630007498863 0.9997764549483796 0.004134097691047156 21.887505454014192 0.19452324794216808 126.02791004357582 0.012604280413468586 1.0000000000000041e-14 13.999999999999998 -8.064611386614668 CLVFSLIGLHFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CLVFSLIGLHFK 12 0 P61326;Q96A72;F5H6P7;P61326-2 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 0 4779650.0 705350.0 3144900.0 929400.0 False True 924720.6806191156 2675693.1787241837 833234.6034343197 1.0 2.8935150200520696 0.9010662580580068 19.818658128130537 -6.657696987018971 1.9811418689576297 2.221129877853491 0.9094063113268626 0.22587299853021692 0.80665985006018 0.48989514429251013 3.693860686386343 0.329245819590175 0.8939692143420331 2.1993938836582636e-07 6.657696987018971 -1.3117235665266285 CLVFSLIGLHFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CLVFSLIGLHFK 12 0 P61326;Q96A72;F5H6P7;P61326-2 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 0 15575170.0 6552500.0 4912000.0 4110670.0 False True 6344494.474157157 6873387.21574161 3033962.209543363 1.0 1.0833624717838082 0.47820393285887663 22.59707378481977 -6.872087729706443 1.123045624624094 1.0477937900979157 0.4413360350292086 0.9667201352115306 0.048853597165817844 0.13486614301233335 0.3166471215671428 0.033716693125036445 0.08012477181653666 1.3424937431430858e-07 6.872087729706443 -0.6064577550687071 down CLVFSLIGLHFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CLVFSLIGLHFK 12 0 P61326;Q96A72;F5H6P7;P61326-2 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 0 200166400.0 49971100.0 73146300.0 77049000.0 False True 75809812.07676037 60092771.27034967 61820231.37822362 1.0 0.7926780138895927 0.8154647753991033 26.175881252955495 -9.923091270765255 5.377205849125458 1.000000317203444 0.8040713947250641 0.9899573704219579 0.009302656435114383 3.537030867427236e-08 7.088850561974092e-09 0.009007272990293408 0.0030024194535296735 1.1937372038376406e-10 9.923091270765255 -0.1959289224783799 CLVFSLIGLHFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CLVFSLIGLHFK 12 0 P61326;Q96A72;F5H6P7;P61326-2 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 0 16421250.0 705350.0 6217700.0 9498200.0 False True 966136.9563670264 5942981.454815664 7254920.781569369 1.0 6.151282606104948 7.5092053292838665 19.881868189653428 -9.252724757458942 0.4575622204207246 2.3054142796508097e-14 7.589028199061609 0.997745466149667 0.13312774291379648 0.6364945035570638 0.1840755791489418 1.515090622959684 0.29780289200839877 5.588242482237054e-10 9.252724757458942 7.589028199061586 CLVFSLIGLHFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CLVFSLIGLHFK 12 0 P61326;Q96A72;F5H6P7;P61326-2 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 0 14901800.0 6552500.0 2551100.0 5798200.0 False True 5448694.074968497 2537356.7179462994 7010576.812152236 1.0 0.46568162628234355 1.2866526759795684 22.377479060254046 -6.7310542537714655 1.7194017009128058 0.678830902387915 1.2862587952167353 0.5641659098586355 0.2245960949864933 0.33425235008366805 1.9363853754398803 0.1034951683779886 0.25650875335061596 1.8575723853623472e-07 6.7310542537714655 0.6074278928288203 CLVFSLIGLHFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CLVFSLIGLHFK 12 0 P61326;Q96A72;F5H6P7;P61326-2 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 0 138027100.0 49971100.0 48121000.0 39935000.0 False True 64688574.02764401 45443024.048241325 32667239.767702885 1.0 0.7024891911950588 0.504992423449354 25.947007575047945 -8.323649262256604 0.120995907516604 1.47422315383108 8.079213810988579e-11 0.9999651100448332 0.001201756040695574 0.09402277451067523 0.02620394252292082 0.15003063375443634 0.1467773494938247 4.746251394446532e-09 8.323649262256604 -1.474223153750288 CLYASVLTAQPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CLYASVLTAQPR 12 0 P13639 P13639 EEF2 Elongation factor 2 0 459960000.0 137370000.0 176500000.0 146090000.0 False True 180093400.29297236 150166887.99161148 130974008.19423267 1.0 0.8338278234922711 0.7272560126088283 27.424170072275025 -10.556718165451635 0.04950126921772738 1.9506544213701487 9.594013454748864e-11 0.9999931335672408 0.00029402928739964316 2.5621557134108386 0.027678525266648154 0.6983590159308478 0.4153983239565236 2.7751204293650457e-11 10.556718165451635 -1.9506544212742085 CLYASVLTAQPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CLYASVLTAQPR 12 0 P13639 P13639 EEF2 Elongation factor 2 0 146820000.0 74898000.0 25184000.0 46738000.0 False True 72520403.98709251 35240102.53282501 34495915.69005491 1.0 0.4859336213722305 0.47567186327581185 26.111883626091064 CLYASVLTAQPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CLYASVLTAQPR 12 0 P13639 P13639 EEF2 Elongation factor 2 0 636750000.0 135180000.0 350580000.0 150990000.0 False True 205077942.98177287 288016259.90595794 121146760.31873219 1.0 1.4044233900452012 0.5907352031978378 27.61159709117983 -6.771546539781031 1.568391453131496 1.2315047416846914 0.5858720355456132 0.7365057310738012 0.17051811961962285 0.2639281542166566 1.281454797844178 0.08568373998773866 0.20368671556984005 1.6922068947726862e-07 6.771546539781031 -0.6456327061390782 CLYASVLTAQPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CLYASVLTAQPR 12 0 P13639 P13639 EEF2 Elongation factor 2 0 398410000.0 137370000.0 105140000.0 155900000.0 False True 188159401.28466514 100494567.1485146 119079630.86128573 1.0 0.5340927238415104 0.63286569817009 27.487380133797917 -10.016293502864016 5.922735470169178 1.0000006214458883 0.5834792110057455 0.9595309366648834 0.040323897913867986 3.3090911360095516e-07 5.4910958544866226e-08 0.039043504445001334 0.013014482089519797 9.631778732579688e-11 10.016293502864016 -0.4165214104401428 CLYASVLTAQPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CLYASVLTAQPR 12 0 P13639 P13639 EEF2 Elongation factor 2 0 156108000.0 74898000.0 27797000.0 53413000.0 False True 62281005.5439895 27647252.043727532 64581411.346191406 1.0 0.4439114590755939 1.0369359129980185 25.89228890152534 -11.818615702343347 14.00655451303999 0.913175951566827 0.7663813174331342 0.0 0.2779474096386183 0.0 0.0 0.0 0.0806577134417438 1.5183933661459622e-12 11.818615702343347 -0.14679463413369276 CLYASVLTAQPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CLYASVLTAQPR 12 0 P13639 P13639 EEF2 Elongation factor 2 0 485910000.0 135180000.0 215210000.0 135520000.0 False True 174993174.7961706 203233374.31520563 110856750.5526256 1.0 1.1613788626438077 0.6334918529351209 27.38272341327228 -6.824676048196884 1.351645203396975 1.0865957286711947 0.6207827527339244 0.8947672785702637 0.07164802743659897 0.18748267872039992 0.67173735842243 0.041641718240333477 0.09587307633280616 1.4973521544203925e-07 6.824676048196884 -0.46581297593727033 CMALAQLLVEQNFPAIAIHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CMALAQLLVEQNFPAIAIHR 20 0 O00148 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 56564000.0 17752000.0 21962000.0 16850000.0 False True 26931081.84503942 18042709.510110807 13519590.114382632 1.0 0.6699585859167477 0.5020069446958693 24.682768849532895 -13.999999999999998 0.08682620945919874 2.714792191847292 0.05815657063257336 0.9998570507317042 0.002473280821937027 12.192745501574317 0.08482246892464126 3.903311443558947 0.4000016353704125 1.0000000000000041e-14 13.999999999999998 -2.6566356212147184 CMALAQLLVEQNFPAIAIHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CMALAQLLVEQNFPAIAIHR 20 0 O00148 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 33606600.0 17752000.0 8654800.0 7199800.0 False True 22980313.944234483 8173152.771819365 5889510.276186495 1.0 0.35565888227866976 0.25628502249701035 24.453895171625344 -13.999999999999998 0.26316134980752914 5.7956575547798 0.22104946898633596 0.9995688501102872 0.0068453909926863505 14.559209620808469 0.16234802742292828 37.20109924264906 0.04273335859428145 1.0000000000000041e-14 13.999999999999998 -5.574608085793464 CMMAQYNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CMMAQYNR 8 0 P31948;P31948-2;P31948-3;H0YGI8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 4828210.0 820910.0 2104100.0 1903200.0 False True 1076220.9597037483 1790176.4817175611 1706275.120783516 1.0 1.6633912075177792 1.5854319741674636 20.037542878391925 -10.498481407689596 5.987025874183103 0.9993793222939317 1.6244115908426209 0.9884440257518866 0.031826723741140005 0.00026391889412796414 2.2107904618460754e-05 0.030844452519505638 0.010272030917814914 3.1733545134306163e-11 10.498481407689596 0.6250322685486892 CMMAQYNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CMMAQYNR 8 0 P31948;P31948-2;P31948-3;H0YGI8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 4151610.0 820910.0 1891400.0 1439300.0 False True 1124422.611258604 1807831.6939766095 1099366.983313974 1.0 1.6077866772467717 0.9777168942586592 20.100752939914816 -6.6543467296787995 1.9928244585702533 1.3930250319317872 0.9803523921401206 0.21194150645750265 0.25913391631396737 0.4979679902025869 3.795363208406409 0.10527484688868502 0.2871401617344074 2.2164261748969858e-07 6.6543467296787995 -0.4126726397916666 CMNSVEEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 2 CMNSVEEKR 9 1 Q13571 Q13571 LAPTM5 Lysosomal-associated transmembrane protein 5 1 65290410.0 20010100.0 22649810.0 22630500.0 True False 26233434.87808402 19270546.636267867 20288912.94708455 1.0 0.7345796204662052 0.7733990246177922 24.644903383638315 -10.386041750013986 5.1125403259399 1.000178676585875 0.7539893225419804 0.9816677545710328 0.01584795538177478 3.2299259615625754e-05 3.878813085802415e-06 0.01535579310216315 0.0051149056054118625 4.111101979646655e-11 10.386041750013986 -0.24618935404389453 CMNSVEEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 CMNSVEEKR 9 1 Q13571 Q13571 LAPTM5 Lysosomal-associated transmembrane protein 5 1 13443200.0 6075000.0 4815100.0 2553100.0 True False 5882152.450286884 6737794.540414779 1884366.518641772 1.0 1.1454641132407515 0.32035322691268703 22.4879127449845 -6.861377968224832 1.1788367305045542 1.0792220923431233 0.2793486487465823 0.9552889468792525 0.07603992840645203 0.14538396597860118 0.38313507511902856 0.05028357653079715 0.11755829485385416 1.376011399402117e-07 6.861377968224832 -0.799873443596541 down CMNSVEEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 CMNSVEEKR 9 1 Q13571 Q13571 LAPTM5 Lysosomal-associated transmembrane protein 5 1 23328600.0 9524500.0 6999600.0 6804500.0 True False 14449362.834220251 5750466.691875582 5459587.592481701 1.0 0.39797372090738986 0.3778427917632344 23.784502540593 CMNSVEEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CMNSVEEKR 9 1 Q13571 Q13571 LAPTM5 Lysosomal-associated transmembrane protein 5 1 49158000.0 16478000.0 14874000.0 17806000.0 True False 22570361.901206292 14216817.498259537 13600589.526081188 1.0 0.6298887700821362 0.60258624055799 24.427926215611897 -13.999999999999998 0.3699010654219943 6.152152904505195 0.5997513888740916 0.9997907311105747 0.002621985671648556 22.80893196661411 0.1974083132663322 93.17920823811599 0.007633023817589131 1.0000000000000041e-14 13.999999999999998 -5.552401515631104 CMNSVEEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CMNSVEEKR 9 1 Q13571 Q13571 LAPTM5 Lysosomal-associated transmembrane protein 5 1 14450900.0 6075000.0 4293900.0 4082000.0 True False 5051631.66813181 4270767.908427586 4935527.326964478 1.0 0.8454234570128503 0.9770164673921546 22.268318020418775 -10.139704556071557 5.627296827221355 1.0000012799043168 0.9112199622079329 0.37767648739796733 0.05372262152437739 8.62683989028468e-07 1.318219076783794e-07 0.05201745492123778 0.017338901539871696 7.24928950504593e-11 10.139704556071557 -0.08878131769638387 CMNSVEEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CMNSVEEKR 9 1 Q13571 Q13571 LAPTM5 Lysosomal-associated transmembrane protein 5 1 18975400.0 9524500.0 4992000.0 4458900.0 True False 12329653.005963344 4714190.81167932 3647425.9521775553 1.0 0.3823457812964615 0.29582551515549105 23.55562886268545 -13.999999999999998 0.27690390144616267 5.9490066434034645 0.268974545459715 0.9995983481563167 0.006284009712419778 15.23328770262598 0.16665221859497192 42.615043411201796 0.0347359949003544 1.0000000000000041e-14 13.999999999999998 -5.68003209794375 CMPTFQFFK ddPTM_RPMI8226_Bortezomib_1h_R1 2 CMPTFQFFK 9 0 P10599;P10599-2 P10599 TXN Thioredoxin 0 295716900.0 91014800.0 86898400.0 117803700.0 False True 119321284.18857697 73933497.44731024 105614503.1768835 1.0 0.6196170109137004 0.8851271078340803 26.830276168892052 -10.060905612410792 5.668819163972762 1.0000011755561686 0.752372059373831 0.5369900672115817 0.10839404316884953 1.610415634038094e-06 2.667774792614706e-07 0.10495257986830796 0.03498402700172296 8.691493057213662e-11 10.060905612410792 -0.24762911618233763 CMPTFQFFK ddPTM_RPMI8226_Bortezomib_2h_R1 2 CMPTFQFFK 9 0 P10599;P10599-2 P10599 TXN Thioredoxin 0 89841200.0 51272000.0 12285000.0 26284200.0 False True 49644398.424873896 17190464.56542866 19399579.510902066 1.0 0.3462719885999369 0.39077076420331996 25.565127606122996 -9.781831259180642 6.473312385491761 1.000000008218108 0.3685213764014184 0.9962895575403048 0.018166549068569415 2.143621020602166e-09 4.0490358355517863e-10 0.01758968549982383 0.005863228499941365 1.652603776332462e-10 9.781831259180642 -0.6314786318166896 CMPTFQFFK ddPTM_RPMI8226_Bortezomib_8h_R1 2 CMPTFQFFK 9 0 P10599;P10599-2 P10599 TXN Thioredoxin 0 144466000.0 33941000.0 89781800.0 20743200.0 False True 51490978.4194729 73759536.3215949 16643297.427932482 1.0 1.4324749419346914 0.32322744563809463 25.617816348359536 -6.800973917525181 1.4519759140251125 1.2383223616571106 0.3075521830144038 0.8349807754896673 0.1854397749545633 0.21937251545027664 0.9129697616093493 0.10046935690265499 0.23351293432257886 1.581343007321726e-07 6.800973917525181 -0.9307701786427068 down CMPTFQFFK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 CMPTFQFFK 9 0 P10599;P10599-2 P10599 TXN Thioredoxin 0 309373400.0 91014800.0 103920100.0 114438500.0 False True 124665431.14248773 99328566.36418442 87410483.23488939 1.0 0.7967611025277388 0.7011605577730895 26.893486230414943 -13.999999999999881 0.10051911602075285 2.002193470892712 0.49917035691551365 0.9997911125468302 0.0018009821852160311 12.076486229198878 0.09452367378617396 2.507342999597385 0.18009542712869644 1.000000000000274e-14 13.999999999999881 -1.5030231139771983 CMPTFQFFK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 CMPTFQFFK 9 0 P10599;P10599-2 P10599 TXN Thioredoxin 0 95945550.0 51272000.0 11937350.0 32736200.0 False True 42634939.73472493 11873041.126171546 39581188.06491285 1.0 0.27848148021425007 0.9283744344705878 25.345532881557272 -10.754064732555092 9.803939140953602 1.0015388195657342 0.6034279573425005 0.3317639376458721 0.2653176875596594 0.008947770185511673 0.00022445758651658366 0.2575787575230381 0.08563091544773523 1.7617134395482466e-11 10.754064732555092 -0.39811086222323366 CMPTFQFFK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 CMPTFQFFK 9 0 P10599;P10599-2 P10599 TXN Thioredoxin 0 110312400.0 33941000.0 39969000.0 36402400.0 False True 43937293.577132866 37744690.014425315 29777536.720166028 1.0 0.8590581472243778 0.6777280596013707 25.388942670451986 -6.9676826205267375 0.3085674092896322 1.0284122391335047 0.5026220021133846 0.999958241676176 0.0008523977737436076 0.07706209798402558 0.011708307419706016 0.002887772321891657 0.016121148996269798 1.0772521746531858e-07 6.9676826205267375 -0.5257902370201201 CMQLTDFILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CMQLTDFILK 10 0 P50914;E7EPB3 P50914 RPL14 60S ribosomal protein L14 0 12979400.0 3998800.0 4936700.0 4043900.0 False True 5242465.524434283 4200163.6031058775 3625476.019827898 1.0 0.801180967910918 0.6915593441540323 22.321814038208515 -13.999999999998535 0.07142684130077008 2.137621279037079 0.3051450584222114 0.9999194920401858 0.0011454611901194126 12.34557034258076 0.0726091834451085 2.3202939530243616 0.35513198279479063 1.0000000000033744e-14 13.999999999998535 -1.8324762206148675 CMQLTDFILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CMQLTDFILK 10 0 P50914;E7EPB3 P50914 RPL14 60S ribosomal protein L14 0 13723300.0 3998800.0 4270700.0 5453800.0 False True 5477264.423506724 4082006.3526836787 4165724.7645367538 1.0 0.7452637004642264 0.7605484129374424 22.385024099731407 -10.849729440393114 10.847695125323119 1.0057912568375502 0.7529060567018659 0.9971384098825792 0.006239957737422108 0.0008761386189617876 1.2136916782969658e-05 0.006056837829682303 0.0020139376998394966 1.4134178106370921e-11 10.849729440393114 -0.2528852001356843 CNEIINWLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CNEIINWLDK 10 0 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 40984900.0 4157900.0 17830000.0 18997000.0 False True 5451047.16516087 15169833.500795653 17031372.67209145 1.0 2.7829209766795264 3.1244221809239883 22.37810197258366 -10.123183281792656 0.3815914774890363 8.901223554543878e-17 3.170813358884749 0.9989643571334514 0.029975768859210113 1.4865143030655197 0.1735400545180481 1.7016439009619735 0.09143267417335543 7.530376982473854e-11 10.123183281792656 3.170813358884749 CNEIINWLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CNEIINWLDK 10 0 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 26863900.0 13520000.0 4313900.0 9030000.0 False True 13090815.000473825 6036462.766691317 6664772.105806734 1.0 0.46112199786436714 0.5091181951288366 23.642051582773536 -10.19346939310021 8.288661935789085 1.000000106327743 0.4851200975788501 0.9935249688157963 0.019594365481986016 3.849502259870643e-08 3.71774164666821e-09 0.01897216675563157 0.006324054265936118 6.405169204030714e-11 10.19346939310021 -0.514880008748893 CNEIINWLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CNEIINWLDK 10 0 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 45145900.0 4157900.0 19802000.0 21186000.0 False True 5695187.993022554 18927082.163542785 16182303.13936627 1.0 3.3233463384757895 2.841399293437193 22.441312034106552 -9.951491653610995 5.421618354726333 0.9999956952760531 3.0823728159628545 0.9613777985548608 0.19675405725346548 1.023803265084406e-05 1.9792200888026756e-06 0.1905066879303086 0.06350209891688283 1.1181713136969486e-10 9.951491653610995 2.082377120686801 CNEIINWLDK(ub)NQTAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CNEIINWLDKNQTAEK 16 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 376392500.0 120984700.0 158889200.0 96518600.0 True False 158612113.31750157 135183550.70525083 86531781.1437871 1.0 0.8522902058220947 0.5455559435777281 27.240927713972763 -6.959303073513199 0.44514720251529577 1.0103971510984926 0.3753870912589976 0.9997434703308771 0.0030315176182888924 0.07995102318433515 0.022058329736298794 0.004071433791902002 0.02539147723419201 1.0982391629457664e-07 6.959303073513199 -0.635010059839495 CNEIINWLDK(ub)NQTAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CNEIINWLDKNQTAEK 16 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 221884100.0 102240900.0 76515200.0 43128000.0 True False 98995318.59333926 107068118.38149665 31831482.987733487 1.0 1.0815472883250112 0.321545336082945 26.560856967162742 -6.880349478279113 1.077896999358187 1.05077258441833 0.2673327119211141 0.9739641463724342 0.05497054349597773 0.12731871119434887 0.2704458865583791 0.039273804671173286 0.09505509274749846 1.3171963594794646e-07 6.880349478279113 -0.7834398724972159 down CNEIINWLDK(ub)NQTAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CNEIINWLDKNQTAEK 16 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 302197800.0 140178000.0 117922800.0 44097000.0 True False 212660274.38451624 96878555.00495838 35381208.621598266 1.0 0.4555554876685144 0.16637432037553304 27.66397531754488 -8.840841429917349 0.2719775312543509 1.2577942734866059 8.57402999839479e-19 0.9989797427881574 0.011039087585232176 0.354245056129179 0.08673317214386257 0.19432465101668475 0.10516088971002596 1.4426419944189805e-09 8.840841429917349 -1.2577942734866059 CNEIINWLDK(ub)NQTAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CNEIINWLDKNQTAEK 16 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 338099700.0 120984700.0 133902000.0 83213000.0 True False 165716013.0785823 127985766.88529973 63559803.22553034 1.0 0.7723198531490681 0.38354653871252853 27.304137775495654 -6.963014795727227 0.390632113284678 1.02370952525816 0.11817378236487237 0.9998661872734701 0.0029441510086005832 0.07864128444239117 0.017276952120139247 0.005017759466827756 0.032694154540787515 1.0888929958365566e-07 6.963014795727227 -0.9055357428932876 down CNEIINWLDK(ub)NQTAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CNEIINWLDKNQTAEK 16 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 246979800.0 102240900.0 55810000.0 88928900.0 True False 85017838.38984318 55509340.45258237 107523521.82922362 1.0 0.6529140413809191 1.264717191893097 26.34126224259702 -6.752754729674982 1.6392800579696865 0.7965990558771185 1.2662247556191526 0.6609533062013523 0.14587265773597594 0.29523044053009395 1.5616666983245948 0.07026590732754101 0.17012098257014704 1.7670354824691865e-07 6.752754729674982 0.46962569974203405 CNEIINWLDK(ub)NQTAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CNEIINWLDKNQTAEK 16 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 294194200.0 140178000.0 114358200.0 39658000.0 True False 181463184.32147917 107994065.6410631 32440650.925442934 1.0 0.5951293428739871 0.1787726311909707 27.43510163963733 -7.651601418556104 0.38489955675556015 1.0496160399920529 2.4943405014894774e-26 0.9986821167739676 0.01217139522129046 0.12111424801788356 0.05662273897744331 0.026506156150428967 0.07401126761918334 2.230481273841816e-08 7.651601418556104 -1.0496160399920529 down CNEIINWLDK(ub)NQTAEKEEFEHQQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CNEIINWLDKNQTAEKEEFEHQQK 24 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 1043950000.0 269950000.0 425510000.0 348490000.0 True False 353907064.1995186 362025566.6249889 312431597.7521261 1.0 1.0229396450275245 0.8828068986381964 28.39879531821694 -6.864892011790398 1.1606940709742175 1.0126496462791585 0.8753561834834761 0.9593184143893593 0.012378338297327427 0.14185108151465958 0.3603856925825221 0.008299376280480946 0.019493904090794132 1.3649224851599453e-07 6.864892011790398 -0.13729346279568244 CNEIINWLDK(ub)NQTAEKEEFEHQQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CNEIINWLDKNQTAEKEEFEHQQK 24 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 1252041000.0 535880000.0 427090000.0 289071000.0 True False 518868782.72588193 597629264.2449266 213354633.15588713 1.0 1.1517926769563505 0.41119188561513875 28.950794499135633 -6.853294149870509 1.2190408576629144 1.0812937524738908 0.37964212851733226 0.9449661816445897 0.07493216008914287 0.15387362990708284 0.43836876344289954 0.048053785551757724 0.11146257142272835 1.4018638933680692e-07 6.853294149870509 -0.7016516239565586 down CNEIINWLDK(ub)NQTAEKEEFEHQQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CNEIINWLDKNQTAEKEEFEHQQK 24 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 3470936600.0 1368727700.0 1343998900.0 758210000.0 True False 2076459988.2983665 1104151795.5836658 608349461.1647515 1.0 0.5317472052464178 0.2929743238940455 30.951478926452232 -9.782675495934088 0.17011302091695743 1.6201156350738544 8.549936717601826e-13 0.9996476958685578 0.005512042751212567 1.2595102771005278 0.07341456130222605 0.5384307977273921 0.17131468586889628 1.6493943557420341e-10 9.782675495934088 -1.6201156350729993 CNEIINWLDK(ub)NQTAEKEEFEHQQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CNEIINWLDKNQTAEKEEFEHQQK 24 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 1221290000.0 269950000.0 505760000.0 445580000.0 True False 369757810.1244474 483413850.87533563 340343181.0081569 1.0 1.307379689188 0.9204489308653397 28.462005379739832 -6.694998048890767 1.8483560844381666 1.1917909593740956 0.9216871895521347 0.3940898266465951 0.12987014322402418 0.40599174363523216 2.692858500991302 0.056125905945449514 0.14525782051846742 2.0183754314046336e-07 6.694998048890767 -0.27010376982196094 CNEIINWLDK(ub)NQTAEKEEFEHQQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CNEIINWLDKNQTAEKEEFEHQQK 24 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 1367967000.0 535880000.0 334477000.0 497610000.0 True False 445607963.50921345 332675106.0125137 601657950.3113166 1.0 0.7465645438484971 1.3501956867493834 28.73119977456991 -6.79270327900071 1.4859941929107312 0.8588501134501887 1.357058257626409 0.8098137681545844 0.10792883860609925 0.2313515953583488 1.0092238820621993 0.05716601122819195 0.13355311189371302 1.611746445113483e-07 6.79270327900071 0.4982081441762203 CNEIINWLDK(ub)NQTAEKEEFEHQQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CNEIINWLDKNQTAEKEEFEHQQK 24 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 3749838700.0 1368727700.0 1609491000.0 771620000.0 True False 1771844989.3065586 1519921410.9937055 631193077.4897938 1.0 0.857818500019323 0.35623493098954545 30.72260524854468 -6.947762831786716 0.5828878894961494 1.0059330314650212 0.18318791961352565 0.9990138179104127 0.008671488944458525 0.08439672168188693 0.039777596949156654 0.009057317325398499 0.041933627304111924 1.1278131868077507e-07 6.947762831786716 -0.8227451118514956 down CNLLLSSVSIALGNTGCQVPLFVQIHHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CNLLLSSVSIALGNTGCQVPLFVQIHHK 28 0 Q15042;Q15042-3;Q15042-4 Q15042 RAB3GAP1 Rab3 GTPase-activating protein catalytic subunit 0 81941000.0 21473000.0 26308000.0 34160000.0 False True 32576110.88657797 21613131.854657795 27408261.02714014 1.0 0.663465689010865 0.8413607481436008 24.957311041569188 -10.031661516152937 4.832239534527285 1.0000051818375673 0.752413219730822 0.7208771503494971 0.07262535378829538 100422935.68809986 16.108334783712202 5790.062549086 0.024861590320578105 9.296906941260857e-11 10.031661516152937 -0.24759196210674528 CNLLLSSVSIALGNTGCQVPLFVQIHHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CNLLLSSVSIALGNTGCQVPLFVQIHHK 28 0 Q15042;Q15042-3;Q15042-4 Q15042 RAB3GAP1 Rab3 GTPase-activating protein catalytic subunit 0 43722000.0 21473000.0 11659000.0 10590000.0 False True 27797221.796110164 11010166.400915321 8662728.662576033 1.0 0.39608873439488984 0.3116400885713069 24.728437363661637 -13.999999999999998 0.2771520018380569 5.8454601772132575 0.28549568270245973 0.9995988936215817 0.006139193262427093 15.246359330441482 0.166730413969724 41.8028163210195 0.03386383617420002 1.0000000000000041e-14 13.999999999999998 -5.5599644945107976 CNMK(ub)MELEQANER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CNMKMELEQANER 13 1 Q9Y232-2;Q9Y232;Q9Y232-3;Q9Y232-4 Q9Y232-2 CDYL Chromodomain Y-like protein 1 5420200.0 2508500.0 2911700.0 0.0 True False 3435960.2396635534 2783051.4662956996 0.0 1.0 0.809977785589339 0.0 21.712281911280147 -7.235369005793208 0.8641016483315623 0.9895757184193809 2.564402895719063e-16 0.9889818517236384 0.045515085073177836 0.09675275977837704 0.13866589414093303 0.038505261720962296 0.06772794965618395 5.816088337978828e-08 7.235369005793208 -0.9895757184193806 down CNMK(ub)MELEQANER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CNMKMELEQANER 13 1 Q9Y232-2;Q9Y232;Q9Y232-3;Q9Y232-4 Q9Y232-2 CDYL Chromodomain Y-like protein 1 6250800.0 3987400.0 1036400.0 1227000.0 True False 3315699.7717709905 1030816.7074907068 1483560.026992996 1.0 0.3108896397275813 0.4474349697230256 21.660881949684285 -9.867879077186366 6.64898269460694 1.0000000184300137 0.37916230473255186 0.9649908154884674 0.05574439754156063 1.5241397598150015e-08 2.5402186108644984e-09 0.05397428243921927 0.01799142694355491 1.3555667971434627e-10 9.867879077186366 -0.6208377136974619 CNNVLYIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CNNVLYIR 8 0 P62306 P62306 SNRPF Small nuclear ribonucleoprotein F 0 36323100.0 6864100.0 13677000.0 15782000.0 False True 8998901.572038947 11636444.91252845 14149030.031633804 1.0 1.2930961428320074 1.572306344098389 23.101317482623795 -6.971714627715434 0.2132937397062705 0.8598222686203887 2.013403775305421 0.999992846020847 0.0006249580203612557 0.07575016474366486 0.007003696430147312 0.0081465039535434 0.028716490694599823 1.0672972054221037e-07 6.971714627715434 1.1535815066850323 CNNVLYIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CNNVLYIR 8 0 P62306 P62306 SNRPF Small nuclear ribonucleoprotein F 0 18017600.0 7767700.0 2445000.0 7804900.0 False True 7521118.615324016 3421301.250506562 5760562.548018939 1.0 0.4548926064715667 0.7659183218147889 22.8425158190945 -10.207354102651504 5.67766992101247 1.0000123092357014 0.6104054641431725 0.6765898612424931 0.1269757165792172 1.978502206608267e-05 2.7622149631591454e-06 0.12294758960532239 0.04098123630699831 6.203630140601142e-11 10.207354102651504 -0.38960684509252885 CNNVLYIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CNNVLYIR 8 0 P62306 P62306 SNRPF Small nuclear ribonucleoprotein F 0 85374400.0 6944400.0 69261000.0 9169000.0 False True 10535162.503644183 56900833.41133709 7356743.131084538 1.0 5.401039935706232 0.6983037165814757 23.328709231939936 -6.661099619277209 1.9689393129653185 3.8303469432964357 0.7178683196647881 0.2402847779752174 1.8733761840420307 0.48185846110099806 3.5921538445492947 0.7683868934936973 2.077050545854937 2.1822292906090134e-07 6.661099619277209 -3.1124786236316475 CNNVLYIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CNNVLYIR 8 0 P62306 P62306 SNRPF Small nuclear ribonucleoprotein F 0 61551100.0 6864100.0 14704000.0 39983000.0 False True 9401943.265327718 14054328.660374358 30539838.875733063 1.0 1.4948323196337088 3.248247517973993 23.164527544146686 -6.947660913792436 0.5839586995530841 0.979336743256615 3.851061660958409 0.9990047093136174 0.030431170005864358 0.0844388204830259 0.039955950336316416 0.031748995075698096 0.14663415383085118 1.1280778872611384e-07 6.947660913792436 2.871724917701794 CNNVLYIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CNNVLYIR 8 0 P62306 P62306 SNRPF Small nuclear ribonucleoprotein F 0 17393300.0 7767700.0 2096900.0 7528700.0 False True 6459186.717456367 2085603.5834979396 9102916.361224255 1.0 0.32288950215070605 1.4092976034619094 22.622921094528778 -6.738200923105935 1.693537287713388 0.5962700734855061 1.4096529509610032 0.5966850251626503 0.2845077773510314 0.32110340640482354 1.8076260265580546 0.13294648367207 0.3268531899931185 1.8272546548111237e-07 6.738200923105935 0.8133828774754971 CNNVLYIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CNNVLYIR 8 0 P62306 P62306 SNRPF Small nuclear ribonucleoprotein F 0 28193900.0 6944400.0 12860000.0 8389500.0 False True 8989662.69458888 12144329.695151461 6862697.083539341 1.0 1.3509216205032322 0.7633987299290087 23.099835554032385 -6.744926249298598 1.6685956637610349 1.2075973244764373 0.7626665669658677 0.6268607320875129 0.147437514098088 0.3089819712793406 1.6908954204627737 0.06984979411476563 0.17049138381580708 1.7991764204081458e-07 6.744926249298598 -0.44493075751056965 CNSLCGTKPQSEK(ub)HR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CNSLCGTKPQSEKHR 15 2 P18583-3 P18583-3 SON Protein SON 1 6481250.0 773050.0 2490200.0 3218000.0 True False 1058867.4758907354 2380174.7300098077 2457974.676790363 1.0 2.2478495035533776 2.321324181501257 20.014090607342634 -10.771609763063964 0.5225774385796663 1.1850847251688256e-15 2.316804577349505 0.999766690145513 0.009260955912872872 2.36335787802688 0.2525314499818073 2.986807596374983 0.014336717801765753 1.691960566318813e-11 10.771609763063964 2.3168045773495036 CNTLITLIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 CNTLITLIER 10 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 2940830.0 927640.0 798990.0 1214200.0 False True 1216145.0232785393 679783.8064386267 1088566.2314288272 1.0 0.5589660718308368 0.8950957415376504 20.213883847356854 -9.771075394393671 6.036701936880084 1.0000000104102684 0.7270309066836069 0.46789553218751834 0.13722436303425725 1.9249446905470292e-08 3.935668622930897e-09 0.13286692412001422 0.04428897272680096 1.694043685534906e-10 9.771075394393671 -0.2729691037266615 CNTLITLIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CNTLITLIER 10 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 3317440.0 927640.0 1206900.0 1182900.0 False True 1270613.576528404 1153575.1673154102 903523.382590218 1.0 0.9078882743148642 0.7110921835565797 20.277093908879745 -6.958733218282763 0.4529328219927473 1.0061594398119746 0.6049810918159332 0.9997202931470193 0.0020152769511504113 0.08015676832105628 0.02282694079420234 0.002642140413953672 0.016271474336966844 1.0996811524947056e-07 6.958733218282763 -0.40117834799604146 CNTNTAIELK(ub)LVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CNTNTAIELKLVR 13 1 O14929;F8W9G7 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 32669900.0 7798800.0 7659100.0 17212000.0 True False 11831349.768651059 6292273.7641785685 13810040.655712407 1.0 0.5318305930614016 1.167241348261395 23.49611133581458 -6.709259485374604 1.7978256988471162 0.7119761037653445 1.165722639633761 0.46172604172532283 0.1973046233240153 0.37649609244798826 2.3716786272302364 0.08735074259244015 0.22211299501375523 1.953172111824488e-07 6.709259485374604 0.4537465358684165 CNTNTAIELK(ub)LVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CNTNTAIELKLVR 13 1 O14929;F8W9G7 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 4205800.0 2979800.0 1226000.0 0.0 True False 2477835.7275224957 1219395.2946580534 0.0 1.0 0.49212112050595286 0.0 21.24064911396795 -7.953318781918539 0.5881298729845247 1.0118318441472007 1.1134488260612808e-18 0.989194676140358 0.04243861843403852 0.11197764184825369 0.16267609298691285 0.04529560423451935 0.07674477017662074 1.1134769164510368e-08 7.953318781918539 -1.0118318441472007 CNTNTAIELK(ub)LVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CNTNTAIELKLVR 13 1 O14929;F8W9G7 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 24061000.0 7798800.0 6505300.0 9756900.0 True False 10095700.337330783 6143274.336381721 7981244.314248162 1.0 0.6085040295486772 0.7905587574480579 23.267237657907028 -10.036696443640146 4.782948553600853 1.0000074193814672 0.6995313934919 0.7841055366525586 0.0743235314580354 102822677.32968636 4.656333422555497 8401.714546687082 0.02544292170478014 9.189747026076268e-11 10.036696443640146 -0.30047602588956723 CPEALFQPSFLGMESCGIHETTFNSIMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CPEALFQPSFLGMESCGIHETTFNSIMK 28 0 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 46387300.0 41602000.0 2311900.0 2473400.0 False True 40281367.281783506 3235053.7263992336 1825542.3395905215 1.0 0.08031141802533168 0.04531977097053726 25.26360931819105 -13.042101265947371 0.4773855623653198 9.999999999989143 0.0463490652525261 0.9999105291560554 0.0041810567914101005 16.16921105423865 0.23933946227435765 149.92747057739683 0.007449803071305517 9.076088752004584e-14 13.042101265947371 -9.953650934736617 CPEALFQPSFLGMESCGIHETTFNSIMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CPEALFQPSFLGMESCGIHETTFNSIMK 28 0 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 691578700.0 31006000.0 606654700.0 53918000.0 False True 47038368.842231415 498392428.9701944 43261083.66690112 1.0 10.595444553824192 0.9196977856949193 25.487334696664185 -6.648091324801828 2.0155940178805105 7.235906754944563 0.960399558755754 0.18633798530662937 4.0973743311107595 0.5131413341201396 3.9937687752682653 1.6499917534343536 4.537310309997749 2.2485817173217554e-07 6.648091324801828 -6.2755071961888085 CPEALFQPSFLGMESCGIHETTFNSIMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CPEALFQPSFLGMESCGIHETTFNSIMK 28 0 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 11435300.0 4632200.0 3023800.0 3779300.0 False True 6344849.520498109 2890198.5176305724 2886707.1771267303 1.0 0.4555188437950021 0.45496858007439495 22.597154517692285 CPEALFQPSFLGMESCGIHETTFNSIMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CPEALFQPSFLGMESCGIHETTFNSIMK 28 0 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 88369000.0 31006000.0 31000000.0 26363000.0 False True 40137878.21963352 29274822.74880994 21565204.50722307 1.0 0.7293565092957531 0.5372781388497614 25.258461018756634 -7.644860523518006 0.12157004868199507 1.390841720484069 6.293953570520238e-11 0.9999904675081543 0.0005860075881641032 0.13694601094535813 0.013338321694432416 0.059378114191739405 0.08460141930347742 2.265371729562639e-08 7.644860523518006 -1.3908417204211296 CPEALFQPSFLGMESCGIHETTFNSIMK(ub)CDVDIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CPEALFQPSFLGMESCGIHETTFNSIMKCDVDIR 34 1 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 151850300.0 7860300.0 17110000.0 126880000.0 True False 11924649.764903292 14056586.818959827 101802112.38652034 1.0 1.1787840394550846 8.537115503898907 23.507443558127243 -6.912126163320234 0.8811259928570415 0.7872018236836461 9.53262264177742 0.9916995360203628 0.31993540244069696 0.10302912935681707 0.1312635094980035 0.26472012880177886 0.7419788009125838 1.2242604977472524e-07 6.912126163320234 8.745420818093775 up CPFGALSIVNLPSNLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CPFGALSIVNLPSNLEK 17 0 P61221;D6R9I9;D6RGF4 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 7560100.0 1938600.0 3763200.0 1858300.0 False True 2541523.3734291056 3201745.2288387087 1666020.9420723016 1.0 1.2597740639775468 0.6555206060625176 21.277262068092117 -6.78988774080238 1.4968952015805903 1.145208607015055 0.6491238712083673 0.8009278447478909 0.11042477464670473 0.23551803839892196 1.0425582996466969 0.05806676405056139 0.13595298242713172 1.6222293673249338e-07 6.78988774080238 -0.49608473580668755 CPFGALSIVNLPSNLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CPFGALSIVNLPSNLEK 17 0 P61221;D6R9I9;D6RGF4 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 10923400.0 1938600.0 3255600.0 5729200.0 False True 2655352.8086951436 3111756.8271704777 4376080.956577801 1.0 1.1718807448037813 1.6480224180560903 21.34047212961501 -6.95322752926793 0.5222125309331599 0.992045236925003 1.8491868807991612 0.9994308205734848 0.006539379800813555 0.08221508310119582 0.030795008416050127 0.007382459498935606 0.0393384011405686 1.1137109014537356e-07 6.95322752926793 0.8571416438741581 CPFGALSIVNLPSNLEK(ub)ETTHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CPFGALSIVNLPSNLEKETTHR 22 1 P61221;D6R9I9;D6RGF4 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 39957100.0 6587100.0 10012000.0 23358000.0 True False 9993112.28151527 8225280.375886957 18741281.06182492 1.0 0.8230949622272978 1.8754198425741249 23.252502634112155 -6.863671353266712 1.1671342050951958 0.9029224653702702 1.9300482566138504 0.9579437863735949 0.09435093643614301 0.143062556311805 0.3682605259079215 0.06295337851084261 0.14760498990873694 1.3687642284128579e-07 6.863671353266712 1.0271257912435803 CPFGALSIVNLPSNLEK(ub)ETTHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CPFGALSIVNLPSNLEKETTHR 22 1 P61221;D6R9I9;D6RGF4 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 29005500.0 6587100.0 9406400.0 13012000.0 True False 8527130.801152935 8882925.57110986 10643949.514394663 1.0 1.0417250278263372 1.2482451322261314 23.023628956204604 -6.94003168806302 0.6592682164226271 0.9976831583744017 1.303989071611156 0.9981680545543447 0.0046453965908532565 0.08775215043669217 0.05454374760135194 0.00452303521408856 0.01777228734918051 1.1480698501423325e-07 6.94003168806302 0.30630591323675427 CPFIVALNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CPFIVALNK 9 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 8524000.0 2147900.0 2262100.0 4114000.0 False True 2815917.700293191 1924603.497596738 3688322.744274578 1.0 0.6834729215972292 1.3098119820371714 21.425173738841305 -6.769302322924573 1.5769897191263405 0.8182869831104915 1.3132535689910394 0.7279313014658779 0.13337716447539028 0.267560051551399 1.3130519544781711 0.06666809431988828 0.15880822102616654 1.700974006891875e-07 6.769302322924573 0.49496658588054787 CPFIVALNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CPFIVALNK 9 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 9361800.0 2147900.0 3924100.0 3289800.0 False True 2942036.674814971 3750720.2867365982 2512816.9955577836 1.0 1.2748720363836004 0.8541079780101036 21.488383800364197 -6.7304224774707 1.7215403425419733 1.1653380582104687 0.8543322976948791 0.5612776716826953 0.11554601495392385 0.3354527583818019 1.9478592521456108 0.05318229725786865 0.1319127185172021 1.8602765970903244e-07 6.7304224774707 -0.3110057605155896 CPFTGNVSIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CPFTGNVSIR 10 0 P62280;M0QZC5 P62280 RPS11 40S ribosomal protein S11 0 273113000.0 91442000.0 60791000.0 120880000.0 False True 119881347.52558763 51721219.76146206 108372497.16283694 1.0 0.4314367566682767 0.9039979896764655 26.83703196475936 -10.120028756757923 7.517913833043025 1.000000080530362 0.6677173731723764 0.3973112757919868 0.19292231551508832 2.6046937245899593e-07 3.054534509170502e-08 0.18679627470249965 0.06226540959180916 7.585273475673974e-11 10.120028756757923 -0.3322827073579855 CPFTGNVSIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CPFTGNVSIR 10 0 P62280;M0QZC5 P62280 RPS11 40S ribosomal protein S11 0 113916000.0 0.0 80962000.0 32954000.0 False True 0.0 66513698.54100671 26440627.455748685 0.0 CPFTGNVSIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CPFTGNVSIR 10 0 P62280;M0QZC5 P62280 RPS11 40S ribosomal protein S11 0 226533000.0 91442000.0 58481000.0 76610000.0 False True 125250578.52713363 55897116.049194284 58516295.83247666 1.0 0.44628229830559246 0.46719381675191224 26.90024202628225 -10.794938830566828 10.962785551670077 1.0030687934053129 0.45673805754124414 0.9988899777296245 0.008537091656713586 0.0006401011398580924 1.197319418448742e-05 0.008263108532032373 0.0027553344842915 1.6034712202196373e-11 10.794938830566828 -0.5463307358640688 CPFTGNVSIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CPFTGNVSIR 10 0 P62280;M0QZC5 P62280 RPS11 40S ribosomal protein S11 0 18056000.0 0.0 0.0 18056000.0 False True 0.0 0.0 21831426.118488614 0.0 CPFTGNVSIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CPFTGNVSIR 10 0 P62280;M0QZC5 P62280 RPS11 40S ribosomal protein S11 0 74761000.0 0.0 50266000.0 24495000.0 False True 0.0 47468652.91263475 20037161.339924473 0.0 CPLDPYFIMPDKCK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 CPLDPYFIMPDKCK 14 1 P33992;B1AHB1;B1AHB2 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 6584300.0 1700900.0 2936600.0 1946800.0 True False 2229896.371539031 2498470.7267771456 1745363.811024248 1.0 1.1204425275838041 0.7827107274135935 21.088545235639895 -6.810265836337783 1.413270889872598 1.0656195022055692 0.7767577769415561 0.8605604824928037 0.052186852216875704 0.20643452244649668 0.8125730638619295 0.029034033152103584 0.06715816274490567 1.5478688616463663e-07 6.810265836337783 -0.2888617252640131 CPLDPYFIMPDKCK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CPLDPYFIMPDKCK 14 1 P33992;B1AHB1;B1AHB2 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 15383200.0 4072000.0 2947700.0 8363500.0 True False 5271284.271120027 2783657.9037634544 6841428.816756818 1.0 0.5280796406701836 1.2978675527402683 22.329723065504027 -6.740763415155418 1.6835393168161852 0.7194752170578872 1.2984330330182887 0.608604668800296 0.19827709279702693 0.31639256700301205 1.7610054255729055 0.09315355375458631 0.22843117419802023 1.816504946595452e-07 6.740763415155418 0.5789578159604015 CPLLKPWALTFSYGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CPLLKPWALTFSYGR 15 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 20995817550.0 7336686200.0 5435048650.0 8224082700.0 False True 11130289349.006985 4465121754.178582 6598589149.601503 1.0 0.4011685243903339 0.5928497402621624 33.37377204711966 -10.146545553893816 6.184576511478043 1.0000026503655566 0.49700913232625193 0.90177982745011 0.07825352869371957 2.859645940532615e-06 3.946934983191318e-07 0.07576905179579681 0.025256217784393426 7.135993505357246e-11 10.146545553893816 -0.5029935180393046 CPLLKPWALTFSYGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CPLLKPWALTFSYGR 15 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 1463344970.0 547086970.0 369450000.0 546808000.0 False True 454927055.6171643 367459699.51991683 661143024.6454647 1.0 0.8077332288390997 1.4532945809269204 28.761059996858812 -6.826895144604255 1.3417356964708196 0.8970247692154456 1.4695889562749052 0.8995196154386994 0.08578776145214637 0.1846735961209074 0.6512884892418845 0.05021701675031984 0.1155884407681312 1.4897207101853365e-07 6.826895144604255 0.5725641870594596 CPLLKPWALTFSYGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CPLLKPWALTFSYGR 15 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 20294663940.0 7336686200.0 6649702040.0 6308275700.0 False True 9497484913.605932 6279640275.916123 5160234250.974682 1.0 0.6611898132020215 0.543326396189608 33.1448983692121 -13.999999999999996 0.14725191135349644 2.631753526308342 0.4094648865017018 0.999575669480282 0.003987463186539449 11.948444854499867 0.1207040526408427 5.583597624500668 0.12034833015157066 1.0000000000000082e-14 13.999999999999996 -2.2222886398066404 CPLPRPWALTFSYGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CPLPRPWALTFSYGR 15 1 P09972;A8MVZ9 P09972 ALDOC Fructose-bisphosphate aldolase C;Fructose-bisphosphate aldolase 0 10781100.0 3058000.0 5033600.0 2689500.0 False True 4009067.613714121 4282606.5008191215 2411216.339505708 1.0 1.068230050840072 0.6014406769438055 21.934835318353763 -6.8697603778877 1.1352862383460598 1.0385376101172976 0.5742184458740979 0.9644473748643726 0.03881533367674561 0.1370888549195866 0.3303734758580801 0.02653668846383074 0.06280428784911721 1.3497073786409221e-07 6.8697603778877 -0.46431916424319974 CPLPRPWALTFSYGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CPLPRPWALTFSYGR 15 1 P09972;A8MVZ9 P09972 ALDOC Fructose-bisphosphate aldolase C;Fructose-bisphosphate aldolase 0 131916000.0 37924000.0 26818000.0 67174000.0 False True 57533480.61577714 22032118.370009653 53897029.456589945 1.0 0.3829442984189607 0.9367941741006021 25.77789841611673 -10.51709679139236 9.064754829561352 1.0000142641770848 0.6598692362597866 0.33460169156305686 0.22610826492065314 6.518375899144558e-05 3.4726604115546176e-06 0.21893754864008297 0.07297612870646207 3.040207377878644e-11 10.51709679139236 -0.3401450279172983 CPLPRPWALTFSYGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CPLPRPWALTFSYGR 15 1 P09972;A8MVZ9 P09972 ALDOC Fructose-bisphosphate aldolase C;Fructose-bisphosphate aldolase 0 17043000.0 3058000.0 7664000.0 6321000.0 False True 4188625.23934269 7325379.138541155 4828109.985081385 1.0 1.7488743250973455 1.1526717500845332 21.998045379876654 -10.06600906867468 4.478711587943202 0.9999727061618578 1.450773036854047 0.43252636889624874 0.24339868212545343 168856322.003708 3.2750081513215057 51495.02745479089 0.08332184290110221 8.589955842919087e-11 10.06600906867468 0.45080033069218917 CPLPRPWALTFSYGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CPLPRPWALTFSYGR 15 1 P09972;A8MVZ9 P09972 ALDOC Fructose-bisphosphate aldolase C;Fructose-bisphosphate aldolase 0 107750000.0 37924000.0 30185000.0 39641000.0 False True 49093365.59380066 28505178.215252504 32426744.751008157 1.0 0.5806319829670028 0.660511748559013 25.54902473820918 -10.83732438951976 7.355834539187133 1.0241276295397959 0.6205718657630083 0.9678282937801458 0.03261077774559225 0.011761624147771358 0.0002601101617938238 0.02878090736286331 0.010525083259629186 1.4543723539286597e-11 10.83732438951976 -0.4035557637767876 CPNLTHLNLSGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CPNLTHLNLSGNK 13 0 H0YN26;P39687 H0YN26 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 0 46265500.0 6023700.0 17407800.0 22834000.0 False True 7897129.033593772 14810624.095072921 20471356.7191944 1.0 1.8754441053286175 2.5922530367822083 22.912896832513205 -6.973408920490136 0.15662520185490048 0.24004606042491614 4.2466130647211005 0.9999982384980284 0.0008641430021484281 0.075211258954777 0.004818481257726762 0.03427373419366804 0.08711355500467002 1.0631415201532242e-07 6.973408920490136 4.006567004296184 CPNLTHLNLSGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CPNLTHLNLSGNK 13 0 H0YN26;P39687 H0YN26 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 0 50213500.0 6023700.0 22122800.0 22067000.0 False True 8250824.674371671 21145341.54568348 16855229.084130835 1.0 2.5628155221094637 2.0428538660487803 22.976106894036096 -9.658999659653023 6.524509772085254 0.999999997829746 2.3028346940813433 0.8932872294938246 0.21227345720150664 7.292847435406924e-09 1.4082339394428612e-09 0.2055328911422973 0.0685109637140992 2.1928066538038335e-10 9.658999659653023 1.3028346962515973 CPNLTHLNLSGNK(ub)IK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CPNLTHLNLSGNKIK 15 1 H0YN26;P39687 H0YN26 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 1 28908500.0 12291100.0 9729400.0 6888000.0 True False 16113751.127181733 8277811.444904157 6175295.83436152 1.0 0.5137110148698152 0.38323142672500543 23.94178904296329 -13.999999999999998 0.18464591013917114 3.560412644692095 0.28440858461762175 0.9994932645876323 0.005974222410783302 12.268407516370551 0.13625204309148412 11.28304511052617 0.09370640922949706 1.0000000000000041e-14 13.999999999999998 -3.2760040600744733 CPNLTHLNLSGNK(ub)IK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CPNLTHLNLSGNKIK 15 1 H0YN26;P39687 H0YN26 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 1 23352700.0 19108500.0 2695100.0 1549100.0 True False 18501911.12696407 3771267.484760834 1143344.2379961496 1.0 0.2038312398584984 0.061796007458379675 24.141170963655266 -13.99999999999351 0.24245449562095978 6.333250645597809 0.00044167305398802223 0.9995291015961731 0.008959738722543336 13.711365219580173 0.15583331723183438 35.45599215557517 0.06841690150486672 1.0000000000149456e-14 13.99999999999351 -6.332808972543821 CPNLTHLNLSGNK(ub)IK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CPNLTHLNLSGNKIK 15 1 H0YN26;P39687 H0YN26 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 1 58794500.0 18914800.0 17860500.0 22019200.0 True False 28695134.45710636 14673154.230276572 17667095.468641777 1.0 0.5113464184044888 0.6156826166836976 24.774302798684538 -10.733899712972374 5.785931720811882 1.0125988734011704 0.5635145175440932 0.9589069708417945 0.04259507458098569 0.0069271032733814715 0.0003185834938860227 0.04126962457920189 0.013747501206885029 1.84544151825581e-11 10.733899712972374 -0.4490843558570772 CPNLTHLNLSGNK(ub)IK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CPNLTHLNLSGNKIK 15 1 H0YN26;P39687 H0YN26 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 1 22667100.0 12291100.0 8452100.0 1923900.0 True False 16835451.824488245 8078658.274642956 1469514.4439642576 1.0 0.4798599027138689 0.08728690261978919 24.00499910448618 -8.120102500160462 0.42165168163943695 1.059018967728391 4.1733828155117122e-16 0.9966116945545177 0.021760021030325215 0.09872890277382224 0.10449131247312604 0.0540841507021521 0.08106295243489126 7.583985602097054e-09 8.120102500160462 -1.0590189677283905 CPNLTHLNLSGNK(ub)IK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CPNLTHLNLSGNKIK 15 1 H0YN26;P39687 H0YN26 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 1 29101200.0 19108500.0 8493400.0 1499300.0 True False 15889564.400081731 8447644.368392099 1812796.6980200484 1.0 0.5316473224620711 0.11408724949129026 23.921576239089543 -7.90435556021791 0.4206665626349481 1.0475848947364066 2.4351957387058916e-21 0.9971756593956577 0.019231432894033115 0.10526020331991726 0.08655924372087768 0.03922184054198062 0.08022000248156533 1.2463626897435284e-08 7.90435556021791 -1.0475848947364066 down CPNLTHLNLSGNK(ub)IK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CPNLTHLNLSGNKIK 15 1 H0YN26;P39687 H0YN26 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 1 59134500.0 18914800.0 27484000.0 12735700.0 True False 24485581.466449235 25954491.2396223 10417933.279317237 1.0 1.059990806229609 0.4254721617941626 24.545429120776987 -6.883731387592049 1.0587345123760803 1.039390350006316 0.377151830365897 0.9765741599785779 0.043777632051883085 0.12437768646337807 0.2527294744975133 0.03173664614783836 0.0775316192818675 1.3069790085351074e-07 6.883731387592049 -0.662238519640419 down CPNLTYLNLSGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CPNLTYLNLSGNK 13 0 Q9BTT0;E9PPH5;Q9BTT0-3;Q5TB19;E9PLC4 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 0 30905400.0 5781400.0 10045000.0 15079000.0 False True 7579471.387157249 8546325.155103317 13518769.727981629 1.0 1.1275621634490653 1.7836032405753257 22.85366580377331 -6.939179069447419 0.6671626209313184 0.9925215014685653 1.9563213026588606 0.9980543182258752 0.015142936203138705 0.08814323387159811 0.05633135911637775 0.014650358354804681 0.05667146093023572 1.1503259857000007e-07 6.939179069447419 0.9637998011902953 CPNLTYLNLSGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CPNLTYLNLSGNK 13 0 Q9BTT0;E9PPH5;Q9BTT0-3;Q5TB19;E9PLC4 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 0 33782400.0 5781400.0 13455000.0 14546000.0 False True 7918939.816460392 12860513.610265015 11110534.384273654 1.0 1.624019617314557 1.4030330627313494 22.916875865296202 -10.096089482548193 4.723985930597829 0.99997348982826 1.5135263399515235 0.8780487769036318 0.09021738315246397 62774780.59992287 1.080619675699463 18828.2448520562 0.0308838098905225 8.01512901707913e-11 10.096089482548193 0.5135528501232636 CPNLTYLNLSGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CPNLTYLNLSGNK 13 0 Q9BTT0;E9PPH5;Q9BTT0-3;Q5TB19;E9PLC4 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 0 9645200.0 6810600.0 0.0 2834600.0 False True 5663315.660737192 0.0 3427301.7542904215 1.0 0.0 0.6051758297795978 22.433215514033716 -10.109995877326984 6.715620095571392 1.0000007354614227 0.3025879148897986 0.6390854424635604 0.2470619979375725 2.7205321400211e-06 3.604095357009638e-07 0.23921700392897463 0.07973891695774553 7.762544854265106e-11 10.109995877326984 -0.6974128205716241 CPNLTYLNLSGNK(ub)IK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CPNLTYLNLSGNKIK 15 1 Q9BTT0;E9PPH5;Q9BTT0-3;Q5TB19;E9PLC4 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 169508000.0 27709000.0 40629000.0 101170000.0 True False 35869846.726047434 38367960.43423864 82758098.09186192 1.0 1.0696438355945683 2.307177354949941 25.096268244799873 -6.9184908285157904 0.8358539901253731 0.9711813421720049 2.49996741334994 0.9937511360060798 0.04746681765783569 0.09906773038920891 0.11027899874817954 0.040574039090508565 0.11983728359201934 1.2064495658780903e-07 6.9184908285157904 1.5287860711779349 up CPNPTCENMNFSWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CPNPTCENMNFSWR 14 0 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 6745100.0 1746700.0 3060300.0 1938100.0 False True 2289940.615066864 2603715.168955966 1737564.003567954 1.0 1.1370230091665237 0.758781250542263 21.126878754782016 -6.8086843201405305 1.41990464011301 1.0747941955594111 0.752351813471161 0.8563992772511202 0.0592511306290772 0.20860173140580865 0.8291246334192577 0.032812872863022535 0.0759545287540404 1.5535158188264914e-07 6.8086843201405305 -0.32244238208825016 CPQIVIAFYEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 CPQIVIAFYEER 12 0 Q13185;P45973 Q13185;P45973 CBX3;CBX5 Chromobox protein homolog 3;Chromobox protein homolog 5 0 9629200.0 3437100.0 3632100.0 2560000.0 False True 4506071.3849237515 3090204.8378149094 2295115.7572539933 1.0 0.6857869247597815 0.5093385260013651 22.103438738170425 -11.522578205800883 0.0897725817281102 2.113677774330572 7.050776886953381e-13 0.9999113127096916 0.0019110301224137024 4.480066133908316 0.06092153536607817 1.3421747602545457 0.3534342503134427 3.0020767716742697e-12 11.522578205800883 -2.113677774329867 CPQIVIAFYEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 CPQIVIAFYEER 12 0 Q13185;P45973 Q13185;P45973 CBX3;CBX5 Chromobox protein homolog 3;Chromobox protein homolog 5 0 263737000.0 35867000.0 122080000.0 105790000.0 False True 54412861.22893362 100293870.18460654 84880560.13059588 1.0 1.8432015505054171 1.559935614734064 25.69744435683025 -10.18010437931983 4.81353215254793 0.9999206629956278 1.701568582622407 0.8910534552082754 0.11564283403448558 81135841.30028562 10.66813438280245 71345.82405147019 0.03958761800768647 6.605346745280169e-11 10.18010437931983 0.7016479196267792 CPQIVIAFYEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CPQIVIAFYEER 12 0 Q13185;P45973 Q13185;P45973 CBX3;CBX5 Chromobox protein homolog 3;Chromobox protein homolog 5 0 11060900.0 3437100.0 3732100.0 3891700.0 False True 4707888.754134987 3567203.4815956955 2972560.6120773964 1.0 0.7577076833989725 0.6313999262337212 22.166648799693316 -13.999999999948884 0.08238459085187494 2.288444712969857 0.27030904112039156 0.9998766455114091 0.0016986573845649332 12.23504908728321 0.08144424517930271 2.8426687846612135 0.32699035333720844 1.0000000001177e-14 13.999999999948884 -2.0181356718494654 CPQIVIAFYEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CPQIVIAFYEER 12 0 Q13185;P45973 Q13185;P45973 CBX3;CBX5 Chromobox protein homolog 3;Chromobox protein homolog 5 0 190048000.0 35867000.0 83944000.0 70237000.0 False True 46430538.54426875 79272442.6072936 57454586.69247905 1.0 1.7073341187225743 1.2374309774093946 25.4685706789227 -10.123561486141494 4.042226957258902 0.9998727399972418 1.472382547903123 0.5740041838105211 0.1918371546846755 134904845.49881172 213315532.32327238 227909.1503685992 0.07020522360667097 7.523822025629409e-11 10.123561486141494 0.47250980790588115 CPQVVISFYEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 CPQVVISFYEER 12 0 P83916;J3KS05 P83916 CBX1 Chromobox protein homolog 1 0 47886400.0 9513400.0 21170000.0 17203000.0 False True 14432523.322701572 17392048.09803505 13802819.50965725 1.0 1.2050594140165571 0.956369111695539 23.782820220928702 -6.68770082749136 1.8748755492885243 1.128837004706725 0.9572582259199868 0.3595805421530507 0.08676680390939806 0.4216148706652 2.8716657184081402 0.0370498550198761 0.09675060645160403 2.0525756500342353e-07 6.68770082749136 -0.17157877878673833 CPQVVISFYEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CPQVVISFYEER 12 0 P83916;J3KS05 P83916 CBX1 Chromobox protein homolog 1 0 30391900.0 9513400.0 11956000.0 8922500.0 False True 12315283.83714965 11290638.08983133 7298696.552581187 1.0 0.9167988524773236 0.5926535392196415 23.55394654302115 -6.945481686413767 0.6064352927268806 1.0036055134876711 0.48906970347376266 0.9987971915772283 0.006094521517636165 0.08535268491632933 0.04387543348210403 0.006216024551129163 0.027298912205592944 1.1337526458486435e-07 6.945481686413767 -0.5145358100139085 CPSIAAAIAAVNALHGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CPSIAAAIAAVNALHGR 17 0 Q14498-3;Q14498-2;Q14498 Q14498-3 RBM39 RNA-binding protein 39 0 63584900.0 9127900.0 29117000.0 25340000.0 False True 11966765.294709353 24772857.097177085 22718059.878443826 1.0 2.070138127312437 1.8984294685287884 23.51252989803467 -10.207707243138938 4.6184182249760415 0.9997845791890286 1.9842837979276662 0.9776846459939236 0.07009976643213624 49315854.81557659 44.55819538327795 113155.82636250735 0.02399701459032992 6.198587795799975e-11 10.207707243138938 0.9844992187386375 CPSIAAAIAAVNALHGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CPSIAAAIAAVNALHGR 17 0 Q14498-3;Q14498-2;Q14498 Q14498-3 RBM39 RNA-binding protein 39 0 31167800.0 18453000.0 5684000.0 7030800.0 False True 17867219.61566154 7953650.841668431 5189222.560521159 1.0 0.4451532478336274 0.2904325727307084 24.09081181292876 -13.999999999999998 0.17916353269594354 3.871523467898119 0.16646270831682547 0.999499170557797 0.006817723519160509 12.194009934281642 0.13417377812456477 12.187059487018827 0.11634631065677094 1.0000000000000041e-14 13.999999999999998 -3.705060759581294 CPSIAAAIAAVNALHGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CPSIAAAIAAVNALHGR 17 0 Q14498-3;Q14498-2;Q14498 Q14498-3 RBM39 RNA-binding protein 39 0 86169900.0 9127900.0 35041000.0 42001000.0 False True 12502731.302222438 33492772.754908673 32081228.837747663 1.0 2.6788364834294347 2.565937638925746 23.575739959557563 -10.480287291364954 5.620816353965709 0.9980548872436618 2.6223870611775926 0.9963812642686577 0.046090760263984024 0.0011240943026186 0.00010393594513858408 0.044652154433268774 0.014875728909702936 3.309121464379047e-11 10.480287291364954 1.6243321739339307 CPSIAAAIAAVNALHGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CPSIAAAIAAVNALHGR 17 0 Q14498-3;Q14498-2;Q14498 Q14498-3 RBM39 RNA-binding protein 39 0 30786500.0 18453000.0 2742900.0 9590600.0 False True 15344487.106508028 2728123.453276979 11595950.118075823 1.0 0.17779176549471667 0.7557078993639126 23.871217088363036 -10.19093510179236 7.094518052753527 1.0000009705221937 0.46674983245529356 0.5316590621665291 0.2359332736835843 3.6218624855205333e-06 4.1312054081101757e-07 0.22844182858761264 0.07614713664939321 6.442655332694657e-11 10.19093510179236 -0.5332511380669002 CPVTVCGDVHGQFHDLMELFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CPVTVCGDVHGQFHDLMELFR 21 0 P67775;P67775-2;E7ESG8;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0 49825000.0 13768000.0 21144000.0 14913000.0 False True 20887062.575625423 17370688.00117398 11965439.013399899 1.0 0.8316482003288033 0.5728636551969355 24.316106279376086 -6.964847369256851 0.3606639214276399 1.0221310160985377 0.3735034641783495 0.9999099614529324 0.0016669518796253791 0.07801281396776358 0.015042923792628258 0.003467348727937995 0.02209471099553834 1.0843079219601964e-07 6.964847369256851 -0.6486275519201883 CPVTVCGDVHGQFHDLMELFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CPVTVCGDVHGQFHDLMELFR 21 0 P67775;P67775-2;E7ESG8;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0 27230300.0 13768000.0 6167800.0 7294500.0 False True 17822947.407853775 5824556.508068062 5966975.847890549 1.0 0.3268009703884017 0.33479175533341754 24.087232601468536 -10.152388065195126 5.0171169192470755 1.0000374101412368 0.3307963628596618 0.9998930751904122 0.003262224297609433 9130273.918587627 0.2881060533778762 3945.890198932563 0.0011167461464919874 7.040636695100878e-11 10.152388065195126 -0.6692410472815751 CQCLDGYYGALCDQCPGCK(ub)TPCER ddPTM_RPMI8226_Bortezomib_1h_R1 1 CQCLDGYYGALCDQCPGCKTPCER 24 1 P26010 P26010 ITGB7 Integrin beta-7 1 106532300.0 2891000.0 2881300.0 100760000.0 True False 3790128.996483821 2451421.271219436 90334321.75816871 1.0 0.6467909861362684 23.83410217487945 21.853815520470008 -6.903441714460356 0.9392470010700349 0.124863938648808 26.4455847550647 0.9882023382879244 1.1783112879025166 0.1089162604659949 0.16347397828525384 0.934452565386531 2.4760967143191306 1.2489880568008653e-07 6.903441714460356 26.320720816415893 up CQCLDGYYGALCDQCPGCK(ub)TPCER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CQCLDGYYGALCDQCPGCKTPCER 24 1 P26010 P26010 ITGB7 Integrin beta-7 1 85624000.0 2891000.0 4046000.0 78687000.0 True False 3959880.8263373836 3867234.3416672056 60102751.2096344 1.0 0.9766037189669999 15.177919196428267 21.9170255819929 -6.906522880107817 0.9190581279378232 0.5104970008804867 16.88316440950421 0.9895426564168343 0.6840306439343141 0.10676341326444969 0.15156016468977174 0.5505698703357005 1.485640404877146 1.240158287648643e-07 6.906522880107817 16.372667408623723 up CQHAAEIITDLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CQHAAEIITDLLR 13 0 Q96AE4;E9PEB5;Q96AE4-2 Q96AE4;Q96AE4-2 FUBP1 Far upstream element-binding protein 1 0 6751200.0 1240900.0 2966900.0 2543400.0 False True 1626831.916892693 2524250.084885618 2280233.366015547 1.0 1.5516354570342006 1.4016404167745087 20.633633769817084 -10.032498702910377 4.536312996422753 0.9999839924678936 1.4766379367759621 0.9308610597787359 0.06123521891388963 21170064.35635474 1.0427578403287703 4304.6564678184 0.02096244419931324 9.279002614450724e-11 10.032498702910377 0.4766539443080685 CQHAAEIITDLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CQHAAEIITDLLR 13 0 Q96AE4;E9PEB5;Q96AE4-2 Q96AE4;Q96AE4-2 FUBP1 Far upstream element-binding protein 1 0 8058760.0 3515100.0 888960.0 3654700.0 False True 3403515.0745684635 1243926.3638651588 2697424.4313501515 1.0 0.36548284247657636 0.792540762197788 21.698594068935705 -9.90521612943178 6.315519690241366 1.0000000513027707 0.5790118023372651 0.5644033303392261 0.1743456656553978 1.2596060304514174e-07 2.190637944604827e-08 0.16880948501519127 0.0562698216305434 1.2438954251841338e-10 9.90521612943178 -0.4209882489655056 CQHAAEIITDLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CQHAAEIITDLLR 13 0 Q96AE4;E9PEB5;Q96AE4-2 Q96AE4;Q96AE4-2 FUBP1 Far upstream element-binding protein 1 0 8460700.0 1240900.0 2507100.0 4712700.0 False True 1699694.2640615914 2396328.0321289836 3599657.321103151 1.0 1.409858280278428 2.117826362784449 20.696843831339976 -6.962806456586217 0.39388990994232115 0.9583599855473854 2.5949219495385676 0.9998605446546035 0.005452604121747771 0.07871341762270492 0.01753547843035969 0.009123761880130062 0.05945707589685007 1.0894154833739527e-07 6.962806456586217 1.6365619639911821 up CQK(ub)LLDGGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CQKLLDGGAR 10 1 C9JYM0;O75817 C9JYM0 POP7 Ribonuclease P protein subunit p20 1 3293400.0 1002000.0 1092500.0 1198900.0 True False 1313631.703381804 929503.258531646 1074849.3286608642 1.0 0.7075828454343325 0.8182273051828605 20.32512942018817 -10.314800976343964 6.2400697025207075 1.0000125670164937 0.7629050754665125 0.8595984994450663 0.04517041154163461 7.897709111570697e-06 8.672119901694986e-07 0.04373838005509644 0.01457868763684047 4.843942995724979e-11 10.314800976343964 -0.23710749154998112 CQK(ub)LLDGGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CQKLLDGGAR 10 1 C9JYM0;O75817 C9JYM0 POP7 Ribonuclease P protein subunit p20 1 3070640.0 1142600.0 972470.0 955570.0 True False 1106328.7884276193 1360782.3423640537 705277.5505144782 1.0 1.2299981312951993 0.6374936256669782 20.077348771300578 -6.801458088306873 1.4501329452335572 1.1266642701864713 0.6290333397875731 0.836353625686659 0.09866420107647136 0.21867681835313071 0.9077326034632094 0.053523804788609526 0.12435762709038879 1.5795810382301707e-07 6.801458088306873 -0.49763093039889816 CQK(ub)LLDGGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CQKLLDGGAR 10 1 C9JYM0;O75817 C9JYM0 POP7 Ribonuclease P protein subunit p20 1 26324500.0 1216000.0 2982500.0 22126000.0 True False 1844760.9015078847 2450249.572621138 17752786.401829682 1.0 1.3282206765214581 9.623353567022574 20.81500241077947 -6.915240523943209 0.8592704062069993 0.7837422367267877 10.82485728907996 0.9927537177040556 0.339647108200178 0.10105410318385186 0.12071979119122811 0.2854900634089681 0.8198760591634768 1.2155126306717061e-07 6.915240523943209 10.041115052353172 up CQK(ub)LLDGGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CQKLLDGGAR 10 1 C9JYM0;O75817 C9JYM0 POP7 Ribonuclease P protein subunit p20 1 3270720.0 1002000.0 812020.0 1456700.0 True False 1372466.4780318455 776142.2714089483 1112657.4616782237 1.0 0.5655090917207374 0.8106991897345317 20.38833948171106 -10.154820772843623 5.40578673786592 1.0000084168764412 0.6881041407275532 0.6832943900786171 0.10009843835308459 1.0154276394661357e-05 1.587560284595652e-06 0.09692251062384108 0.032306632060197474 7.001308704443315e-11 10.154820772843623 -0.31190427614888794 CQK(ub)LLDGGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CQKLLDGGAR 10 1 C9JYM0;O75817 C9JYM0 POP7 Ribonuclease P protein subunit p20 1 4961810.0 1142600.0 810910.0 3008300.0 True False 950122.5257625352 806541.4668769682 3637321.621192366 1.0 0.8488815337049989 3.828265852631142 19.857754046734854 -6.894953046511211 0.9926020313050002 0.8583995576823767 4.110856782723886 0.9838843931259691 0.1739514898975094 0.11521704097720918 0.19909976494506929 0.1325816166015076 0.33700684242399775 1.2736407724855111e-07 6.894953046511211 3.252457225041509 up CQK(ub)LLDGGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CQKLLDGGAR 10 1 C9JYM0;O75817 C9JYM0 POP7 Ribonuclease P protein subunit p20 1 14814500.0 1216000.0 2458500.0 11140000.0 True False 1574135.9709435084 2321682.3138048113 9112634.306052595 1.0 1.4748931202005613 5.788975332664972 20.58612873287192 -6.927811177351202 0.7645433030882105 0.9287924614765528 6.627214180852546 0.996090291064589 0.13470663416120987 0.09379058519249733 0.08336524335523751 0.12116238112856464 0.39515309503692564 1.1808339272894891e-07 6.927811177351202 5.698421719375993 up CQLEINFNTLQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CQLEINFNTLQTK 13 0 A0A494C1A0;P35609-2;P35609;F6THM6;O43707;O43707-2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;K7EJH8;Q08043;A0A087WSZ2 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1;ACTN3 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-3 0 23842600.0 6285900.0 9650500.0 7906200.0 False True 8240875.772742192 8210683.017354362 7088142.265625597 1.0 0.9963362200547062 0.8601200237807957 22.974366232685817 -6.912665743147241 0.8773768784533525 1.0038703167650038 0.841473930058759 0.9918894338903732 0.005862248063812222 0.10268173480310147 0.12939778406669025 0.0048636780103744354 0.013687513653359962 1.2227403861653644e-07 6.912665743147241 -0.1623963867062448 CQLEINFNTLQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CQLEINFNTLQTK 13 0 A0A494C1A0;P35609-2;P35609;F6THM6;O43707;O43707-2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;K7EJH8;Q08043;A0A087WSZ2 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1;ACTN3 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-3 0 26717900.0 9943300.0 4641600.0 12133000.0 False True 9627655.384187238 6495015.085624237 8955003.317802127 1.0 0.6746206450525694 0.9301333461218506 23.198753071707625 -9.857333520300054 5.932013382295774 1.000000032924914 0.802376995586992 0.4437047601795784 0.10431262340411264 4.54224211016056e-08 8.626200629496081e-09 0.10100027986570818 0.033666754436831245 1.3888856145246884e-10 9.857333520300054 -0.19762303733792186 CQLEINFNTLQTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CQLEINFNTLQTK 13 0 A0A494C1A0;P35609-2;P35609;F6THM6;O43707;O43707-2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;K7EJH8;Q08043;A0A087WSZ2 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1;ACTN3 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-3 0 79145000.0 13606000.0 38469000.0 27070000.0 False True 20641296.731839016 31603906.390331168 21719602.63479753 1.0 1.5311008218578839 1.0522402209980943 24.299030271107817 -10.431142859733121 3.579124493308403 0.9973171722569201 1.2916705211950574 0.330950910792709 0.19549402191319906 141653357.0876764 194415897.62259308 3800065.278926651 0.071543478170002 3.705588076381305e-11 10.431142859733121 0.29435334893813736 CQLEINFNTLQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CQLEINFNTLQTK 13 0 A0A494C1A0;P35609-2;P35609;F6THM6;O43707;O43707-2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;K7EJH8;Q08043;A0A087WSZ2 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1;ACTN3 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-3 0 29819900.0 6285900.0 12701000.0 10833000.0 False True 8609967.10006025 12139827.82340959 8274468.512638288 1.0 1.4099737760118316 0.9610336969325219 23.03757629420871 -6.666449592762796 1.94987352772985 1.262484802287896 0.9628729648720334 0.2633524902865101 0.1742929687825022 0.46938589862644153 3.4370219052222506 0.07204785805557679 0.19339545496086055 2.155511812735873e-07 6.666449592762796 -0.2996118374158626 CQLEINFNTLQTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CQLEINFNTLQTK 13 0 A0A494C1A0;P35609-2;P35609;F6THM6;O43707;O43707-2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;K7EJH8;Q08043;A0A087WSZ2 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1;ACTN3 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-3 0 57344000.0 13606000.0 28214000.0 15524000.0 False True 17613235.21435637 26643866.097900767 12698791.289691243 1.0 1.512718462771883 0.720980054779521 24.070156593200267 -6.731895817526652 1.7164403280773786 1.3078954592162444 0.7212936183677353 0.5680208662367624 0.2155033537618408 0.332674016053331 1.921003185408346 0.0994636608052991 0.2462728006091578 1.8539763186177208e-07 6.731895817526652 -0.5866018408485091 CQNILQGNFK(ub)PDFYLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CQNILQGNFKPDFYLK 16 1 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 1 70387000.0 19143000.0 25433000.0 25811000.0 True False 25096658.3810757 21638495.53705755 23140325.31659482 1.0 0.862206243097854 0.9220480657314895 24.580991946395944 -10.146861077873359 4.57929813446272 1.0000118658176296 0.8921271544676264 0.8124758855193303 0.02443032181035494 34169032.69267492 0.12650991659946434 4816.993002017485 0.008363148960714535 7.1308109404115e-11 10.146861077873359 -0.10788471135000322 CQNILQGNFK(ub)PDFYLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CQNILQGNFKPDFYLK 16 1 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 1 88266000.0 40444000.0 24356000.0 23466000.0 True False 39160127.35792632 34081477.81486205 17319550.635089815 1.0 0.8703106990269707 0.4422751355425355 25.222882121143694 -6.949287899023055 0.5666133312246688 1.0054162364610233 0.2864797203332814 0.9991441661010068 0.006971437900974508 0.0837730799426305 0.037156411475645225 0.00741466454039079 0.0356346781383987 1.1238597068863401e-07 6.949287899023055 -0.7189365161277419 down CQNILQGNFK(ub)PDFYLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CQNILQGNFKPDFYLK 16 1 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 1 184530000.0 71518000.0 65322000.0 47690000.0 True False 108498034.66615197 53664778.73688447 38264050.596730426 1.0 0.4946152149392455 0.35267044895761257 26.69309366902141 -13.999999999999998 0.17813872527073352 3.607497502224837 0.23772290232851798 0.9995005009842708 0.006208869464650772 12.181252696437127 0.13377948438281667 10.989297809169097 0.10768185818252733 1.0000000000000041e-14 13.999999999999998 -3.369774599896319 CQNILQGNFK(ub)PDFYLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CQNILQGNFKPDFYLK 16 1 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 1 72769000.0 19143000.0 24331000.0 29295000.0 True False 26220684.420123346 23255975.96814256 22376124.349463522 1.0 0.8869324536126338 0.8533768223185938 24.644202007918835 -13.999999999998884 0.17026303883971 1.5705964941707242 0.8238596511615218 0.9995131704950437 0.0013839418180962325 12.094144973835835 0.13067242733700846 2.2792660458419287 0.02729223630057709 1.0000000000025687e-14 13.999999999998884 -0.7467368430092024 CQNILQGNFK(ub)PDFYLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CQNILQGNFKPDFYLK 16 1 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 1 196443000.0 71518000.0 79578000.0 45347000.0 True False 92581460.83054091 75149414.34531604 37094311.29951233 1.0 0.8117112613168622 0.400666731403266 26.464219991113858 -6.958296459801193 0.4588119884792167 1.012124410169997 0.18371655219265107 0.9997017060914734 0.004322053463522329 0.08031536345245541 0.02342290105919269 0.005571266601875806 0.03396090986765489 1.1007876290478445e-07 6.958296459801193 -0.8284078579773461 down CQNIYLTTGYAGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CQNIYLTTGYAGSK 14 0 O15226;O15226-2 O15226 NKRF NF-kappa-B-repressing factor 0 15682300.0 4489500.0 4320900.0 6871900.0 False True 5885777.976379846 3676238.5627362835 6160861.707919422 1.0 0.6245968803936128 1.0467370214512866 22.488801691212217 -6.672089380436029 1.9297319174472318 0.7608173008481546 1.045056170222494 0.28843765174498115 0.15938599236845533 0.45633707127580675 3.278061194304489 0.06644282651676178 0.17705149970451697 2.1277011071381448e-07 6.672089380436029 0.2842388693743395 CQNIYLTTGYAGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CQNIYLTTGYAGSK 14 0 O15226;O15226-2 O15226 NKRF NF-kappa-B-repressing factor 0 12718900.0 4489500.0 2247300.0 5982100.0 False True 6149389.474175615 2148006.8551726937 4569251.185216794 1.0 0.349304083631921 0.7430414359678114 22.55201175273511 -10.79912970790587 7.0076124428486555 1.0177529038867703 0.5461727598000831 0.6391662182035969 0.16074260098289495 0.04281486589322411 0.0012272686578890138 0.14946479044020508 0.05187945138606801 1.5880723785230592e-11 10.79912970790587 -0.47158014408668725 CQQCQAEAK(ub)CPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CQQCQAEAKCPK 12 1 P29590;P29590-4;P29590-2;P29590-5;P29590-9;P29590-3;P29590-8;P29590-11;H3BT57;P29590-14;P29590-10;P29590-12;P29590-13 P29590 PML Protein PML 1 12201700.0 5043100.0 4272000.0 2886600.0 True False 6611552.937449875 3634634.2521255724 2587922.3222224084 1.0 0.5497398699688061 0.39142427606736957 22.656557744539757 -13.999999999999998 0.14568201966801114 3.1640291351574463 0.20829218305670405 0.9995812844252489 0.005275305395809224 11.944148424483423 0.11996753055914897 7.327761488045732 0.1644229148137097 1.0000000000000041e-14 13.999999999999998 -2.955736952100742 CQQCQAEAK(ub)CPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CQQCQAEAKCPK 12 1 P29590;P29590-4;P29590-2;P29590-5;P29590-9;P29590-3;P29590-8;P29590-11;H3BT57;P29590-14;P29590-10;P29590-12;P29590-13 P29590 PML Protein PML 1 11616400.0 3221800.0 2363200.0 6031400.0 True False 4887706.145130014 1941468.4962341257 4839291.14634347 1.0 0.39721465214690854 0.9900945356883241 22.220726120498124 -10.856770091102307 10.87165347915535 1.0084930838190729 0.6936545939233062 0.2625270890125546 0.24204219890619708 0.048994226444315864 0.0006454789927363018 0.23044503230013907 0.07811878378692697 1.3906886458101174e-11 10.856770091102307 -0.3148384898957667 CQQCQAEAK(ub)CPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CQQCQAEAKCPK 12 1 P29590;P29590-4;P29590-2;P29590-5;P29590-9;P29590-3;P29590-8;P29590-11;H3BT57;P29590-14;P29590-10;P29590-12;P29590-13 P29590 PML Protein PML 1 12415000.0 5043100.0 4401900.0 2970000.0 True False 6907670.354653092 4207409.502863289 2268547.1690700343 1.0 0.6090923982828923 0.3284098766441443 22.71976780606265 -8.011073554838562 0.2132299855892827 1.2299594054197835 1.0222497348571951e-09 0.9997912971970583 0.003978628930373926 0.10144898549448088 0.038034944059757624 0.07678479105890017 0.10167712912566133 9.748245213374545e-09 8.011073554838562 -1.2299594043975337 down CQQCQAEAK(ub)CPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CQQCQAEAKCPK 12 1 P29590;P29590-4;P29590-2;P29590-5;P29590-9;P29590-3;P29590-8;P29590-11;H3BT57;P29590-14;P29590-10;P29590-12;P29590-13 P29590 PML Protein PML 1 9506000.0 3221800.0 1982100.0 4302100.0 True False 4170683.6111725247 1871794.3925940678 3519161.9432736854 1.0 0.4487979830404448 0.8437854009943291 21.991852442590574 -10.241599315619663 5.763098283680844 1.0000150628648081 0.6462916920173919 0.5167236140752831 0.161252938134426 3.12098632793409e-05 4.107176612519101e-06 0.15613912912789193 0.052044161993468036 5.733247421234623e-11 10.241599315619663 -0.35372337084741623 CQSGFAYHLFPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CQSGFAYHLFPR 12 0 H7BXY3;Q7L2E3-3;Q7L2E3;Q7L2E3-2 H7BXY3 DHX30 Putative ATP-dependent RNA helicase DHX30 0 7895500.0 2237500.0 2414300.0 3243700.0 False True 2933384.16798082 2054095.8508676894 2908073.0397674916 1.0 0.7002478138694038 0.9913713558252579 21.48413459403194 -10.732166862849573 9.363247432581005 1.0004789271348853 0.8458095849213683 0.2722103862082086 0.11885068831726213 0.0011917919758749158 3.4090851752919545e-05 0.11542186606164968 0.0383588947115037 1.852819603868785e-11 10.732166862849573 -0.15466934221351702 CQSGFAYHLFPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CQSGFAYHLFPR 12 0 H7BXY3;Q7L2E3-3;Q7L2E3;Q7L2E3-2 H7BXY3 DHX30 Putative ATP-dependent RNA helicase DHX30 0 6322900.0 2237500.0 2435200.0 1650200.0 False True 3064764.216163921 2327604.811870487 1260456.7469358167 1.0 0.7594727188455248 0.41127364391949695 21.54734465555483 -6.965840989838124 0.3433148936280392 1.0363459808607856 0.12277040441305417 0.9999294436693708 0.0020300735743821866 0.07767674218715548 0.013860234123460772 0.0048671165431177525 0.03006620861740589 1.0818299739938633e-07 6.965840989838124 -0.9135755764477314 down CQSLQCK(ub)GEPQPSSHSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CQSLQCKGEPQPSSHSR 17 1 O94886;Q2HIZ8 O94886 TMEM63A CSC1-like protein 1 1 21937890.0 865390.0 8765500.0 12307000.0 True False 1312859.8984834775 7201228.039835907 9874516.055650271 1.0 5.485145862215956 7.521378379411703 20.32428153692777 -8.776511376288521 0.3689919331452805 2.909359650471509e-20 8.072564121515773 0.9976776317687134 0.1312815675420543 0.3235690152065874 0.12328213879621554 1.0445518828269296 0.5490574838932025 1.6729718125415708e-09 8.776511376288521 8.072564121515773 CQSLQCK(ub)GEPQPSSHSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CQSLQCKGEPQPSSHSR 17 1 O94886;Q2HIZ8 O94886 TMEM63A CSC1-like protein 1 1 16428390.0 865390.0 5469000.0 10094000.0 True False 1120264.4143871737 5164645.3423626255 8256995.573186257 1.0 4.6102020880381875 7.370577398643106 20.09540785902022 -7.917725817393041 0.2913102484600678 4.603847198864787e-22 9.310282297554876 0.9992762887489216 0.0701730070716481 0.11449038087492207 0.05446252104828046 0.4606202289352951 0.7720293002841433 1.2085766034995287e-08 7.917725817393041 9.310282297554876 CQSLQEELDFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CQSLQEELDFR 11 0 Q03252 Q03252 LMNB2 Lamin-B2 0 2520600.0 0.0 0.0 2520600.0 False True 0.0 0.0 1925286.1933865116 0.0 CQVFEETQIGGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 CQVFEETQIGGER 13 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 38495600.0 4860600.0 16911000.0 16724000.0 False True 6372293.670117354 14387944.718561713 14993560.907935856 1.0 2.25789103004362 2.352929994147575 22.603381324991407 -10.731926770809636 0.48571606088485586 9.09506412850457e-15 2.350446572076474 0.9996695939973326 0.011207952217010007 2.2924866602662948 0.23337272815964025 2.722149219980641 0.019842235138511004 1.8538441856733058e-11 10.731926770809636 2.350446572076465 CQVFEETQIGGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CQVFEETQIGGER 13 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 29784700.0 4860600.0 16521000.0 8403100.0 False True 6657695.172776028 15791047.592358846 6418460.847276915 1.0 2.3718489931665836 0.9640664945914968 22.6665913865143 -6.6520458931525255 2.001279267681529 1.8887168332179618 0.9699762946281649 0.20252439524112487 0.5852191309068993 0.5034268239230136 3.867091371514565 0.23697104880443035 0.6482657254233326 2.2281996765321695e-07 6.6520458931525255 -0.9187405385897969 CQYVTEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CQYVTEK 7 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 0 42762500.0 1133500.0 23668000.0 17961000.0 False True 1486029.4768296147 20136826.65714141 16102568.014077727 1.0 13.55075856240923 10.835968105041847 20.503031302733746 -10.13911431566001 10.582483887817741 0.9999999913207288 12.19336333372554 0.9577464465259968 1.1083085631878433 2.3972317267531544e-07 1.2088399755101163e-08 1.073115159916674 0.3577050506404655 7.259148558628601e-11 10.13911431566001 11.19336334240481 CQYVTEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CQYVTEK 7 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 0 11691200.0 6866700.0 1938400.0 2886100.0 False True 6648720.367141539 2712413.228622464 2130143.828855905 1.0 0.4079601906597558 0.3203840304945342 22.664645271197763 -13.999999999999998 0.26911503251963115 5.547943601570255 0.2910641073584792 0.9995814290346329 0.006175690820477237 14.839777721306158 0.16421152902962685 36.90458276055713 0.03653366178326039 1.0000000000000041e-14 13.999999999999998 -5.256879494211776 CQYVTEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CQYVTEK 7 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 0 30734500.0 1133500.0 14941000.0 14660000.0 False True 1552585.5816857244 14280857.216720171 11197609.932177357 1.0 9.198112738632217 7.212233621298685 20.566241364256637 -9.353732353984654 8.206236960179952 1.0000000139336631 8.205173179970945 0.9460969104635899 0.8107317547421833 0.0 0.0 0.7849876577764644 0.2616625486930789 4.4286121378232675e-10 9.353732353984654 7.205173166037282 CQYVTEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CQYVTEK 7 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 0 8049640.0 6866700.0 447260.0 735680.0 False True 5709965.296388579 444850.52160584135 889507.2866000064 1.0 0.07790774523396825 0.15578155740501598 22.44505054663204 -10.544968449490206 6.202903364899556 1.0013289858829446 0.11684465131949223 0.9942024464493966 0.031791850690734265 0.0005849635957968104 4.291159472187432e-05 0.030817489516180043 0.010260775689193872 2.8512253950428736e-11 10.544968449490206 -0.8844843345634523 CQYVTEK(ub)VLAAVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CQYVTEKVLAAVYK 14 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 1 69669000.0 15044000.0 20616000.0 34009000.0 True False 19474754.5615741 19468701.47707951 27819710.96180817 1.0 0.9996891830150951 1.4285012359898808 24.21510181046864 -6.906730939455635 0.917704151941441 0.9853116059259054 1.4802120104597865 0.9896283597892711 0.02057913391231788 0.10662007775300938 0.150785587975409 0.016580654678853012 0.04479718252776979 1.2395643019127145e-07 6.906730939455635 0.49490040453388107 CSASCCEDSQASMK(ub)QVHQCIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSASCCEDSQASMKQVHQCIER 22 1 E7EQY1;Q96C01;C9JF51 E7EQY1 FAM136A Protein FAM136A 1 39274000.0 10798000.0 14027000.0 14449000.0 True False 14156282.567980757 11934226.276817767 12953956.084594894 1.0 0.8430339122935476 0.9150676402782937 23.754939128442217 -10.146413750654691 4.612519665767352 1.0000139771782353 0.8790507762841032 0.7898721204420016 0.029407646311723067 4.22736384248876e-06 7.823026237848528e-07 0.028477120989015163 0.009491277033828651 7.138159523656971e-11 10.146413750654691 -0.12096320089413204 CSASCCEDSQASMK(ub)QVHQCIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 CSASCCEDSQASMKQVHQCIER 22 1 E7EQY1;Q96C01;C9JF51 E7EQY1 FAM136A Protein FAM136A 1 133128800.0 34152000.0 27642000.0 71334800.0 True False 51811080.84563922 22709069.132068254 57235445.51284649 1.0 0.4383052575128744 1.104695068673979 25.626757344583524 -6.683252109816692 1.8904642992569347 0.6456455894813635 1.1022173114962934 0.3389824954668076 0.23789323549498098 0.4313553693838415 2.9833002059996403 0.10087433967331425 0.26493320103605245 2.07370937076403e-07 6.683252109816692 0.4565717220149299 CSASCCEDSQASMK(ub)QVHQCIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CSASCCEDSQASMKQVHQCIER 22 1 E7EQY1;Q96C01;C9JF51 E7EQY1 FAM136A Protein FAM136A 1 44073000.0 10798000.0 15167000.0 18108000.0 True False 14790312.404977908 14496871.78943811 13831263.34596642 1.0 0.9801599447324022 0.9351569437648453 23.81814918996511 -6.957517166831955 0.4692056068231079 1.0011978861139152 0.9122768546384951 0.9996663887909786 0.0004954661731796941 0.08060165929813452 0.024510150595658992 0.000621311366050896 0.0037145101529524167 1.1027646428064808e-07 6.957517166831955 -0.08892103147542019 CSASCCEDSQASMK(ub)QVHQCIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CSASCCEDSQASMKQVHQCIER 22 1 E7EQY1;Q96C01;C9JF51 E7EQY1 FAM136A Protein FAM136A 1 100974000.0 34152000.0 25855000.0 40967000.0 True False 44210437.23656473 24416146.52162842 33511426.356917106 1.0 0.5522710936103291 0.757998075829956 25.397883666675973 -10.061076676848657 4.801287701697116 1.0000097159641017 0.6551345847153022 0.7893298453542933 0.08398768881329173 116474772.28008482 10.195176134276853 13785.142478454234 0.028751219819343584 8.688070235475828e-11 10.061076676848657 -0.34487513124879954 CSDAAGYPHATHDLEGPPLDAYSIQGQHTISPLDLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSDAAGYPHATHDLEGPPLDAYSIQGQHTISPLDLAK 37 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 18473600.0 3307800.0 12508000.0 2657800.0 False True 4336557.832780767 10641855.155802134 2382796.3514178363 1.0 2.4539866793332186 0.5494672141590917 22.048118918917865 -6.702636736235336 1.8211475070824643 1.9005127953105327 0.554785374567242 0.43021683668064437 0.6134541904015713 0.39007863042758917 2.516902414406129 0.2685284159969643 0.6884271083206018 1.9831851589959442e-07 6.702636736235336 -1.3457274207432908 CSDAAGYPHATHDLEGPPLDAYSIQGQHTISPLDLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CSDAAGYPHATHDLEGPPLDAYSIQGQHTISPLDLAK 37 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 31873800.0 3307800.0 10107000.0 18459000.0 False True 4530783.049933868 9660439.320620483 14099364.375038322 1.0 2.1321787457383303 3.1119045471056306 22.111328980440756 -6.972814991116061 0.17857630652994927 0.22817867769312258 5.0423606622299095 0.9999968318010423 0.0015359556457237961 0.07539945167001047 0.005622719176043395 0.03820753975586057 0.11042692456219894 1.0645964383361416e-07 6.972814991116061 4.814181984536787 CSDAAGYPHATHDLEGPPLDAYSIQGQHTISPLDLAK(ub)LNQVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CSDAAGYPHATHDLEGPPLDAYSIQGQHTISPLDLAKLNQVAR 43 1 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 269788000.0 84280000.0 74368000.0 111140000.0 True False 127858921.69332583 61096449.36016386 89173130.28560755 1.0 0.47784267652988555 0.697433773917572 26.92997759104055 -10.271000942948831 5.637962706750869 1.0000320043420416 0.5876382252237223 0.8246174288194205 0.08964769010963312 3.6066578510193624e-05 4.663591931897974e-06 0.0868077240192803 0.028933667568377192 5.3579549418222785e-11 10.271000942948831 -0.4123937791183193 CSDAAGYPHATHDLEGPPLDAYSIQGQHTISPLDLAK(ub)LNQVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CSDAAGYPHATHDLEGPPLDAYSIQGQHTISPLDLAKLNQVAR 43 1 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 54036400.0 20308000.0 7620000.0 26108400.0 True False 16887001.796941668 7578949.547548427 31567545.72839765 1.0 0.4488037390344222 1.8693398690888225 24.00940987176789 -6.8015157652050275 1.4499964468714683 0.6964667128326332 1.8896272489364085 0.8364823556270111 0.23646100122595134 0.21860255780181378 0.9072624682748814 0.12829053179173613 0.298047723953508 1.5793712743739247e-07 6.8015157652050275 1.1931605361037754 CSDAAGYPHATHDLEGPPLDAYSIQGQHTISPLDLAK(ub)LNQVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CSDAAGYPHATHDLEGPPLDAYSIQGQHTISPLDLAKLNQVAR 43 1 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 312348000.0 84280000.0 77704000.0 150364000.0 True False 109102121.40716992 73379704.09269439 122999294.86492757 1.0 0.6725781602251416 1.1273776648750329 26.701103913133 -6.713518316415062 1.7824356578377325 0.7994311427315544 1.126431899122171 0.481787340881192 0.1379015366819025 0.3681050472712575 2.2817868143211406 0.06151495611547505 0.1556271074824215 1.9341122855117857e-07 6.713518316415062 0.32700075639061654 CSDSSLLGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSDSSLLGKR 10 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 3955200.0 1154200.0 1528200.0 1272800.0 True False 1513167.3772886998 1300198.5168769425 1141102.865559719 1.0 0.859256243817947 0.7541154287930475 20.52914014777682 -6.974335621606484 0.11424563656824178 1.20670811286343 0.4039727232823071 0.9999995490023745 6.740119032221014e-05 0.07491948689217565 0.0033872304942288442 0.00792773915836535 0.01567579168642375 1.0608753986791972e-07 6.974335621606484 -0.8027353895811229 CSDSSLLGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 CSDSSLLGKR 10 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 6433200.0 2242300.0 2734800.0 1456100.0 True False 2171119.413872967 3826819.901793596 1074703.7279363438 1.0 1.7626022213891477 0.4949998240857815 21.050007647218514 -6.743807048065329 1.6728488740381233 1.4517335323852794 0.4936345829564806 0.6218796569920949 0.32039913338438336 0.31096667231857905 1.710074191072017 0.15143511024302234 0.37005354575574545 1.8038189784305968e-07 6.743807048065329 -0.9580989494287988 CSDSSLLGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CSDSSLLGKR 10 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 6581800.0 2669700.0 1607300.0 2304800.0 True False 3455979.27765451 1517852.3420697462 1885350.0492450637 1.0 0.4391960194564234 0.5455327991794573 21.720663136329403 -9.945879799549814 5.869924629747441 1.0000003295686821 0.49236440931796394 0.9681388248703829 0.043411808536144944 1.872258890377404e-07 3.361183554608764e-08 0.04203333043029508 0.014011100957321644 1.1327138230589273e-10 9.945879799549814 -0.5076359202507181 CSECIDWGEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSECIDWGEKR 11 1 O95807 O95807 TMEM50A Transmembrane protein 50A 1 34643600.0 1682000.0 1600900.0 31360700.0 True False 2205118.2885111696 1362051.9602593237 28115795.597076304 1.0 0.6176775039034031 12.750243714163403 21.072424617248103 -6.899622758159142 0.9636386903104516 0.4903377404655133 14.014097935654728 0.9863780132077632 0.6572585956165784 0.11168386751065644 0.17898530345660044 0.5119043999099402 1.329400862215213 1.260019429066588e-07 6.899622758159142 13.523760195189215 up CSECIDWGEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 CSECIDWGEKR 11 1 O95807 O95807 TMEM50A Transmembrane protein 50A 1 6086800.0 1082500.0 399900.0 4604400.0 True False 1048136.6300305414 559582.1554509504 3398369.51096086 1.0 0.5338828349455212 3.242296293816042 19.999395361218077 -6.862542821133439 1.17273440025467 0.7451639613432466 3.380019963430005 0.9566620565640321 0.24613004454965506 0.14421016498795147 0.375423624691418 0.16350931686841624 0.38286190945508647 1.3723256439838877e-07 6.862542821133439 2.6348560020867584 up CSECIDWGEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CSECIDWGEKR 11 1 O95807 O95807 TMEM50A Transmembrane protein 50A 1 43909100.0 1682000.0 1392400.0 40834700.0 True False 2303880.8543408797 1330879.1639489434 31190384.877045184 1.0 0.577668398711398 13.538193530397857 21.135634678770995 -6.899366215035135 0.9652537332253138 0.4517382122300828 14.881301127633948 0.9862487057793251 0.7050704721654364 0.11187372121853223 0.1800573301306463 0.5484832248375192 1.4225947095008677 1.2607639580131985e-07 6.899366215035135 14.429562915403865 up CSEGSFLLTTFPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSEGSFLLTTFPR 13 0 Q15233;Q15233-2;H7C367 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 62310000.0 18167000.0 20739000.0 23404000.0 False True 23817112.929478236 17644822.03998883 20982378.58702049 1.0 0.7408463860516858 0.8809790947017252 24.5054952069366 -10.450657425466002 7.587945686528751 1.0000128315521424 0.8109127403767058 0.7082540518111116 0.05720893874444915 1.2419372294450404e-05 8.991267680805669e-07 0.055396072678634806 0.018464105584287654 3.542766868299097e-11 10.450657425466002 -0.18910009117543658 CSEGSFLLTTFPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CSEGSFLLTTFPR 13 0 Q15233;Q15233-2;H7C367 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 35347100.0 19167000.0 5081100.0 11099000.0 False True 18558554.076485343 7110009.727586449 8191838.937137208 1.0 0.38311226716714974 0.44140502020664935 24.14558097661966 -10.402070949245736 5.330916146944471 1.0003816599767013 0.4122586436868888 0.9926763832356167 0.023797916774845464 0.00010801684918069319 1.211547980313812e-05 0.023056684963268112 0.007680744611945117 3.962133009181521e-11 10.402070949245736 -0.5881230162898125 CSEGSFLLTTFPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CSEGSFLLTTFPR 13 0 Q15233;Q15233-2;H7C367 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 51469000.0 18167000.0 16378000.0 16924000.0 False True 24883830.844715063 15654365.80519661 12926899.760720994 1.0 0.6290979030875928 0.51948993872326 24.568705268459492 -13.999999999999998 0.17087154872920235 2.8747756466278505 0.423694824114236 0.9995120418700733 0.0045418327019319076 12.100121713176827 0.13091678804992987 7.5197978224897 0.08865790231185361 1.0000000000000041e-14 13.999999999999998 -2.4510808225136147 CSEGSFLLTTFPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CSEGSFLLTTFPR 13 0 Q15233;Q15233-2;H7C367 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 30378100.0 19167000.0 3937400.0 7273700.0 False True 15938209.742071142 3916188.444687292 8794597.040211044 1.0 0.24571068570831783 0.5517932805838582 23.925986252053935 -10.484398839013423 6.175133360108334 1.0003936839660355 0.39875198315000804 0.8372608624086652 0.12495769609868264 0.0006776876072048337 5.6584193733488676e-05 0.12106517347031763 0.040329922997553766 3.2779412158137474e-11 10.484398839013423 -0.6016417008160274 CSELK(ub)GQLGEAEGENLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSELKGQLGEAEGENLR 17 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7;I3L316;I3L4M5 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 29172000.0 9032300.0 12142000.0 7997700.0 True False 11841432.768917613 10330460.929145303 7170174.723355573 1.0 0.8723995761949993 0.6055158073587555 23.497340316424562 -6.959159899652173 0.44711583058999377 1.008864721773244 0.4585213370088094 0.9997377610612322 0.0026615985103673094 0.08000258904439805 0.022250494217537838 0.0035522360087184386 0.022085515958518577 1.0986012791346766e-07 6.959159899652173 -0.5503433847644346 CSELK(ub)GQLGEAEGENLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CSELKGQLGEAEGENLR 17 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7;I3L316;I3L4M5 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 31169500.0 12168000.0 9987000.0 9014500.0 True False 11781733.500426447 13974861.181516996 6653332.020796776 1.0 1.1861464343096173 0.5647158816277719 23.490048489328487 -6.826402658611727 1.3438618747503992 1.0997383851937532 0.549184148757775 0.8984958842384857 0.0829644024480561 0.18529183991978346 0.6556947368162216 0.04848901965090446 0.11162028202998378 1.4914109981259763e-07 6.826402658611727 -0.5505542364359782 CSELK(ub)GQLGEAEGENLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CSELKGQLGEAEGENLR 17 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7;I3L316;I3L4M5 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 43353000.0 12258000.0 16082000.0 15013000.0 True False 18596282.179838493 13212041.45076048 12045673.969568351 1.0 0.7104668192809293 0.6477463534419742 24.148510886790266 -13.999999999999998 0.21496089340698754 2.7095647790244697 0.6125330579626074 0.9994933688525794 0.00345329886448344 12.867363957680107 0.14691652630379187 9.313475270756461 0.03590199472352039 1.0000000000000041e-14 13.999999999999998 -2.097031721061862 CSELK(ub)GQLGEAEGENLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CSELKGQLGEAEGENLR 17 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7;I3L316;I3L4M5 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 25708600.0 9032300.0 9759900.0 6916400.0 True False 12371785.398729557 9328675.346326686 5282888.767729294 1.0 0.7540282219318674 0.4270110252859532 23.560550377947454 -6.967184841353832 0.3183320523474534 1.0456705932104529 0.12484670947357349 0.9999513575901182 0.0016368872644106104 0.07722717486376533 0.0122855919986608 0.004990880973718664 0.028807983919273753 1.0784876062466913e-07 6.967184841353832 -0.9208238837368794 down CSELK(ub)GQLGEAEGENLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CSELKGQLGEAEGENLR 17 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7;I3L316;I3L4M5 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 27484400.0 12168000.0 9827500.0 5488900.0 True False 10118231.133798804 9774557.306893973 6636603.612193854 1.0 0.966034198827814 0.6559055159379619 23.270453764762763 -6.92772347041704 0.765248494073587 1.0051358162301862 0.5957781075600235 0.9960715666231739 0.009703941183910547 0.09383734253221249 0.083598593367028 0.008723853009143077 0.02842068861287702 1.181072423946451e-07 6.92772347041704 -0.40935770867016275 CSELK(ub)GQLGEAEGENLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CSELKGQLGEAEGENLR 17 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7;I3L316;I3L4M5 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 48350000.0 12258000.0 24881000.0 11211000.0 True False 15868222.641303858 23496350.477843225 9170713.034574121 1.0 1.4807172176097336 0.5779294406106583 23.919637208882715 -6.762050874097808 1.6046793457577095 1.2785199334964992 0.5742880451952752 0.6992738978809947 0.20225573679543588 0.2795055109520348 1.4189411106642487 0.09942399798093603 0.23845696374231057 1.7296137370402773e-07 6.762050874097808 -0.704231888301224 CSESIPK(ub)DSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSESIPKDSLR 11 1 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 2556430.0 771780.0 1191000.0 593650.0 True False 1011811.0539281508 1013307.4424816382 532224.7926929033 1.0 1.0014789209385269 0.5260120361668799 19.948508474957972 -6.906199167195327 0.9212396972752419 1.0165487711740269 0.4693128264408381 0.9894062049813337 0.02303379057612778 0.10698509258121083 0.15280195918283065 0.0185106151414225 0.049846591832520014 1.2410830171186657e-07 6.906199167195327 -0.5472359447331887 CSIHLQLQGLVDPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSIHLQLQGLVDPAR 15 0 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 10446900.0 6479500.0 2816800.0 1150600.0 False True 8494687.247567268 2396544.419800402 1031546.9493345482 1.0 0.282122737418818 0.12143436471189277 23.018129401408213 -13.999999999999718 0.21032852289803533 5.157355552281081 0.027089872764840782 0.9994901986433874 0.008624206111860608 12.754407325604255 0.1453597896839959 21.915799755795753 0.09496532297007233 1.0000000000006503e-14 13.999999999999718 -5.13026567951624 CSIHLQLQGLVDPAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CSIHLQLQGLVDPAR 15 0 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 107480000.0 31073000.0 40371000.0 36036000.0 False True 47140012.74058759 33166479.629937332 28913468.804860126 1.0 0.7035738367839041 0.6133530120997529 25.490448812718583 -13.999999999999998 0.1666409372802012 2.4821987526178537 0.5308537283633386 0.9995204923570654 0.0036166408842521667 12.060604040869109 0.12919608564699953 5.777214906030559 0.07586789866282458 1.0000000000000041e-14 13.999999999999998 -1.9513450242545152 CSIHLQLQGLVDPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CSIHLQLQGLVDPAR 15 0 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 19174300.0 6479500.0 2658800.0 10036000.0 False True 8875146.25190354 2541325.424524167 7665703.497908044 1.0 0.2863418080551748 0.8637270057678098 23.081339462931105 -10.297649544784644 7.908750198626142 1.000001184784781 0.5750344069118678 0.4193795847445888 0.2357165199053228 4.924058060992545e-06 4.3733203139487693e-07 0.2282321748699562 0.07607717966827374 5.039070740689529e-11 10.297649544784644 -0.42496677787291315 CSIHLQLQGLVDPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CSIHLQLQGLVDPAR 15 0 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 88437000.0 31073000.0 31876000.0 25488000.0 False True 40224611.04040103 30102072.578743998 20849445.528964885 1.0 0.7483496247734976 0.5183255969342748 25.261575134811032 -6.972198536917522 0.19878169300439708 1.1390867460818621 0.121245894825988 0.9999948346584089 0.00044703045560403807 0.07559555469233363 0.006408785534792332 0.00754354682950779 0.024495648732053867 1.0661086402241749e-07 6.972198536917522 -1.017840851255874 CSK(ub)ELNQWEALTEYGQSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CSKELNQWEALTEYGQSK 18 1 H0Y4W2;F2Z2U4;Q9Y4A5-2;Q9Y4A5;A0A2R8YFJ4 H0Y4W2 TRRAP Transformation/transcription domain-associated protein 1 21185500.0 4214800.0 5999700.0 10971000.0 True False 5456141.686128865 5665811.420839838 8974390.571966156 1.0 1.0384282056391636 1.6448235929762833 22.379449678352934 -6.919816044744016 0.8260713552173632 0.9865325390902376 1.7422041037323426 0.9941303132099931 0.02262653934732864 0.0982793423376367 0.10616890719201065 0.01947634926337592 0.05824036728374756 1.2027737887928175e-07 6.919816044744016 0.7556715646421049 CSLQAAAILDANDAHQTETSSSQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSLQAAAILDANDAHQTETSSSQVK 25 0 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 0 4255450.0 936250.0 3319200.0 0.0 False True 1227432.816657896 2823988.2981402664 0.0 1.0 2.300727387939274 0.0 20.22721263033907 -6.7559560935015845 1.6450470198740725 1.7616480870374585 4.1767879376223217e-10 0.6630337193262821 0.5467841371400328 0.292205852822223 1.5604465550596904 0.2631712021599153 0.6306694789051558 1.7540578254031848e-07 6.7559560935015845 -1.7616480866197797 CSPHFSDCKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CSPHFSDCKK 10 1 O95905-2;O95905;O95905-3 O95905-2 ECD Protein SGT1 1 1498040.0 470310.0 361670.0 666060.0 True False 644196.3166498572 345690.2235172462 508750.34593629255 1.0 0.5366224776245355 0.7897442639567525 19.297140886219047 -10.091053576651888 5.25330192415492 1.0000056548817853 0.6631833707902371 0.7024554238929889 0.10333653655071037 6.8441628079586235e-06 1.1842358786433244e-06 0.10005685035831917 0.033351723759432766 8.108610199758593e-11 10.091053576651888 -0.33682228409154813 CSPIGVYTSGK(ub)GSSAAGLTASVMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CSPIGVYTSGKGSSAAGLTASVMR 24 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 27206700.0 8239400.0 5773300.0 13194000.0 True False 6851426.167309497 5742198.086989678 15952804.397836672 1.0 0.8381026003589843 2.3283917841737787 22.70797289467423 -6.879985393856565 1.0798432421830126 0.8996700081393969 2.4339938962362213 0.9736752640997551 0.10832538713206932 0.1276447478902308 0.27234365692929335 0.0772745520241874 0.18686855550272272 1.3183010747651294e-07 6.879985393856565 1.5343238880968244 up CSQAVYAAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSQAVYAAEK 10 0 P21291;E9PS42;E9PND2;E9PP21 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 8330020.0 448220.0 4164900.0 3716900.0 False True 587620.7605686547 3543513.1546530416 3332310.843022411 1.0 6.030272230722241 5.67085281295653 19.164525841468432 -10.204028320131457 4.67392278508744 0.9990764050962291 5.850562521868277 0.9958989468602432 0.14673236296130168 0.0014123075192757596 0.00024051827777219078 0.1420856071377253 0.0473576664942381 6.251319268983228e-11 10.204028320131457 4.8514861167720476 CSQAVYAAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CSQAVYAAEK 10 0 P21291;E9PS42;E9PND2;E9PP21 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 6034120.0 448220.0 2752500.0 2833400.0 False True 613939.0466900534 2630885.4486997006 2164209.27570473 1.0 4.285255128963805 3.5251207548578174 19.227735902991324 -10.629068007327279 10.193771939612708 0.9995191849137319 3.9051879419108113 0.9511630521678338 0.310323558751588 0.003391145416088629 0.00012339771466032606 0.30048089664436467 0.10015649791506 2.3492649144060285e-11 10.629068007327279 2.9056687569970796 CSVCPDYDLCSVCEGK(ub)GLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSVCPDYDLCSVCEGKGLHR 20 1 Q13501;Q13501-2;E7EMC7;E9PFW8;C9JRJ8;E3W990 Q13501 SQSTM1 Sequestosome-1 1 144389000.0 41629000.0 44424900.0 58335100.0 True False 54576022.13580942 37796878.08690392 52299143.44179188 1.0 0.6925546532660163 0.9582806037356175 25.701763909426766 -10.156238490609923 7.075487101597551 1.000000187058214 0.8254176290894679 0.3652948750725088 0.10848216501109989 3.200103862724609e-07 3.8269676213363e-08 0.10503751730415498 0.03501246820404289 6.978490785575045e-11 10.156238490609923 -0.1745825579687461 CSVCPDYDLCSVCEGK(ub)GLHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CSVCPDYDLCSVCEGKGLHR 20 1 Q13501;Q13501-2;E7EMC7;E9PFW8;C9JRJ8;E3W990 Q13501 SQSTM1 Sequestosome-1 1 1041874000.0 87184000.0 467050000.0 487640000.0 True False 132264502.00416392 383701278.4216946 391257740.25979567 1.0 2.9010148044833297 2.958146247339125 26.97885067291241 -10.56298914815889 0.6631349279324452 1.96626125559775e-18 2.949291481181469 0.999909429576897 0.008659493218064088 2.0143542126439975 0.3313710642448 3.4127392216051056 0.009222743589513822 2.7353370741068737e-11 10.56298914815889 2.949291481181469 CSVCPDYDLCSVCEGK(ub)GLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CSVCPDYDLCSVCEGKGLHR 20 1 Q13501;Q13501-2;E7EMC7;E9PFW8;C9JRJ8;E3W990 Q13501 SQSTM1 Sequestosome-1 1 179431000.0 41629000.0 64289000.0 73513000.0 True False 57020366.28142476 61448499.40470661 56150743.4477595 1.0 1.0776587982866814 0.9847489083221033 25.764973970949658 -6.684961304059853 1.8846604207472193 1.0489154641976706 0.9850907775694271 0.34686037822743665 0.032878552487337016 0.4275550916740364 2.9403661154736165 0.013978097398793384 0.036628241925625 2.0655641908164317e-07 6.684961304059853 -0.06382468662824348 CSVLAAANPVYGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSVLAAANPVYGR 13 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 15252900.0 1868600.0 5401500.0 7982800.0 False True 2449752.6955481432 4595617.254882089 7156816.43242468 1.0 1.8759515045063757 2.921444456589652 21.224204684709353 -6.968776434313127 0.28590240263739514 0.7854425950669559 4.044071498456462 0.9999712043299139 0.004214812044743969 0.07670173918843443 0.010444284692314766 0.018678197101437404 0.09526872336048513 1.074542421882806e-07 6.968776434313127 3.2586289033895057 CSVLAAANPVYGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CSVLAAANPVYGR 13 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 15566400.0 1868600.0 8000900.0 5696900.0 False True 2559471.9170162748 7647393.78256183 4351409.5513384165 1.0 2.9878795433226872 1.700120060864394 21.287414746232244 -10.000339039729457 4.931038285159501 0.9999841935044151 2.3439998021152615 0.5922258300062191 0.525725607317317 181169733.7410851 6.6280257708947214 32528.85534039017 0.17996985885475295 9.99219636814867e-11 10.000339039729457 1.3440156086108463 CSVLAAANSVFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSVLAAANSVFGR 13 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 43869300.0 8204300.0 11655000.0 24010000.0 False True 10755916.750554226 9916119.430834183 21525675.52018294 1.0 0.9219222927067774 2.0012869213657476 23.358627158299615 -6.8895071401443895 1.0252623850467826 0.941317592950288 2.0932416676769763 0.980582083928992 0.06848253359060032 0.11954521328522481 0.22417520695121163 0.05092566261670888 0.12673913345455312 1.2897123538344327e-07 6.8895071401443895 1.1519240747266881 up CSVLAAANSVFGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CSVLAAANSVFGR 13 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 12148400.0 5614100.0 2006900.0 4527400.0 False True 5435883.468502967 2808265.6358452435 3341538.1209113398 1.0 0.5166162321391035 0.614718497972436 22.37408309805367 -9.98506307879145 5.83786873061748 1.0000005161238703 0.5656673650556795 0.9631474778997736 0.040050082317546795 2.6904127965972576e-07 4.681844664119853e-08 0.038778371104957444 0.01292610848577445 1.0349918291136989e-10 9.98506307879145 -0.4343331510681908 CSVLAAANSVFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CSVLAAANSVFGR 13 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 25554200.0 8204300.0 9116300.0 8233600.0 False True 11237651.422870928 8713511.722427286 6288993.256314831 1.0 0.7753854782053037 0.5596359078655383 23.421837219822507 -6.971615864611572 0.2161359315236236 1.10447883899099 0.22447752160465806 0.999992391030949 0.0004959056804320264 0.07578179587886262 0.00712339716270662 0.00615680939937313 0.02205012265773191 1.0675399475606134e-07 6.971615864611572 -0.880001317386332 CSWLVVQCLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSWLVVQCLQR 11 0 P14324;P14324-2;A0A087X090 P14324 FDPS Farnesyl pyrophosphate synthase 0 11165500.0 2842400.0 4092100.0 4231000.0 False True 3726413.925840758 3481574.630880871 3793216.706617832 1.0 0.9342962698636207 1.0179268278045634 21.82935650543682 -6.697170440822668 1.840777732426359 0.959088619364787 1.017666810294135 0.4042501614794891 0.02774890013258208 0.40143418216463506 2.642444085084623 0.01203482586814544 0.031061066150127416 2.0083044897990332e-07 6.697170440822668 0.05857819092934813 CSWLVVQCLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CSWLVVQCLQR 11 0 P14324;P14324-2;A0A087X090 P14324 FDPS Farnesyl pyrophosphate synthase 0 12309100.0 2842400.0 4336200.0 5130500.0 False True 3893312.0929717734 4144612.346104144 3918781.56596425 1.0 1.0645466500325056 1.0065418523828218 21.89256656695971 -6.62052883130891 2.1143893588027365 1.042811448429907 1.0067620210670087 0.08469249096186426 0.027753264953465098 0.5840003977656468 4.961759094771948 0.010781442900010079 0.030778883105055093 2.395913688040909e-07 6.62052883130891 -0.03604942736289818 CSWSPDGSK(ub)IAAGSADR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSWSPDGSKIAAGSADR 17 1 Q96DI7;Q96DI7-2;Q9NSS8 Q96DI7 SNRNP40;DKFZp434D199 U5 small nuclear ribonucleoprotein 40 kDa protein 1 6301400.0 2155100.0 1715000.0 2431300.0 True False 2825356.9700180865 1459128.6850176428 2179732.398676419 1.0 0.5164404712401004 0.7714892035969761 21.430001725821796 -10.045657829111732 5.084323518038796 1.0000048821994056 0.6439648374181135 0.7220858521689875 0.1041232089754697 5.9060381833088096e-06 1.1086517764537035e-06 0.10081828064139806 0.03360562119214028 9.002065547690944e-11 10.045657829111732 -0.35604004478129214 CSWSPDGSK(ub)IAAGSADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CSWSPDGSKIAAGSADR 17 1 Q96DI7;Q96DI7-2;Q9NSS8 Q96DI7 SNRNP40;DKFZp434D199 U5 small nuclear ribonucleoprotein 40 kDa protein 1 18740200.0 4206400.0 3163800.0 11370000.0 True False 5445267.720540108 2987731.7487962814 9300776.66605189 1.0 0.5486840871985506 1.7080476375786644 22.376571551159017 -6.80114642137054 1.4512983879937655 0.751347696685045 1.724494418029789 0.8354663104032247 0.19354953053377905 0.21913096839401192 0.9110987090145986 0.10491166930170463 0.24380969938105762 1.5807150150449815e-07 6.80114642137054 0.973146721344744 CSYQPTMEGVHTVHVTFAGVPIPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSYQPTMEGVHTVHVTFAGVPIPR 24 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98;A0A669KBC6 P21333-2 FLNA Filamin-A 0 9290200.0 3236800.0 4755100.0 1298300.0 False True 4243476.145215787 4045657.615234626 1163964.370172991 1.0 0.9533829051438908 0.27429501906951376 22.01681513666388 -6.920788138488043 0.8188759873139647 1.0145626917701436 0.16278180782209895 0.9943966477775907 0.024826538726724537 0.09771051879396081 0.1032330156110729 0.02148023531436344 0.06483481037027988 1.2000845966359157e-07 6.920788138488043 -0.8517808839480446 down CSYQPTMEGVHTVHVTFAGVPIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CSYQPTMEGVHTVHVTFAGVPIPR 24 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98;A0A669KBC6 P21333-2 FLNA Filamin-A 0 10301400.0 3236800.0 2620700.0 4443900.0 False True 4433532.431231011 2504908.8085040185 3394342.344993377 1.0 0.5649916510949053 0.7656067475863501 22.08002519818677 -10.058753452001413 4.823194978618815 1.0000087525203532 0.6652991993366607 0.7877439562428403 0.0819007702016027 113554391.20580848 4.755028004871259 12178.533268667072 0.028036812070100746 8.734670929640375e-11 10.058753452001413 -0.33470955318369244 CSYVVTNGLGINVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSYVVTNGLGINVFK 15 0 P43490 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 5852200.0 0.0 3882000.0 1970200.0 False True 0.0 3302820.731917478 1766342.603492897 0.0 CSYVVTNGLGINVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CSYVVTNGLGINVFK 15 0 P43490 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 7156000.0 0.0 2267700.0 4888300.0 False True 0.0 2167505.5157189136 3733784.21769867 0.0 CSYVVTNGLGINVFKDPVADPNKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CSYVVTNGLGINVFKDPVADPNKR 24 2 P43490 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 20152400.0 6328800.0 7493000.0 6330600.0 False True 8297118.088186387 6375073.607485241 5675570.239403178 1.0 0.7683479419874965 0.6840411549022275 22.984178888691314 -13.999999999999998 0.14058892229205622 2.1071513876560197 0.5804436554651685 0.9996005946952303 0.0026696714890784554 11.934667976365418 0.1175188322677342 3.6237555791217453 0.0926521499131445 1.0000000000000041e-14 13.999999999999998 -1.526707732190851 CSYVVTNGLGINVFKDPVADPNKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CSYVVTNGLGINVFKDPVADPNKR 24 2 P43490 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 23925100.0 6328800.0 7367300.0 10229000.0 False True 8668728.389389163 7041788.325596846 7813120.87286781 1.0 0.8123207936952148 0.9012995357463676 23.047388950214206 -10.059653053532072 4.371609310554177 1.0000108380932633 0.8568101647029654 0.7754298875764961 0.036325419388233894 25184621.351337843 0.5794356985954757 2812.3975868848925 0.012435157247481522 8.716596579166665e-11 10.059653053532072 -0.14320067339029785 CSYVVTNGLGINVFKDPVADPNKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CSYVVTNGLGINVFKDPVADPNKR 24 2 P43490 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 32603800.0 7628800.0 13155000.0 11820000.0 False True 9875631.986129787 12422912.685825612 9668881.28344181 1.0 1.2579359683788798 0.9790645598197304 23.23544164500313 -6.663611425785373 1.9595954901867036 1.165525965135277 0.9802054959482481 0.2513312512433685 0.1097275443007341 0.47589929505938544 3.5165591558869194 0.045175242458400044 0.12173019290254523 2.1696444722140329e-07 6.663611425785373 -0.18532046918702882 CTCPALK(ub)GK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CTCPALKGK 9 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y8B3 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 1869250.0 394110.0 842470.0 632670.0 True False 516682.02656666946 716776.7599223397 567207.3773991731 1.0 1.3872686160292653 1.0977880944848082 18.9789171731132 -10.3257729619384 6.843908811195854 0.9999941059455464 1.2425283552570368 0.4834418849032841 0.11817992804311209 1.0628470917388022e-05 1.0470660733465864e-06 0.11443000338196409 0.03814240776391366 4.7230988828030686e-11 10.3257729619384 0.24253424931149037 CTDEAK(ub)SNPEECR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CTDEAKSNPEECR 13 1 Q01668-2;Q01668-3;A0A5F9Z6M3;A0A1B0GTN0;A0A1B0GUN6;A0A1B0GUB6;A0A1W2PQ56;A0A1B0GWE1;Q59GD8;Q01668-4;Q01668;A0A1B0GWF7 Q01668-2 CACNA1D Voltage-dependent L-type calcium channel subunit alpha-1D 1 39499500.0 1877300.0 3460200.0 34162000.0 True False 2461158.479799059 2943951.64775396 30627243.945043307 1.0 1.1961650059992555 12.444238839728786 21.230906128647575 -6.910684035635807 0.8910680813082316 0.6592270326841159 13.919312637885865 0.9911770561671648 0.5024558874851484 0.10396729617123728 0.13632814908878596 0.4127637639860139 1.14488126199969 1.2283325608816504e-07 6.910684035635807 13.260085605201748 up CTDEAK(ub)SNPEECR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CTDEAKSNPEECR 13 1 Q01668-2;Q01668-3;A0A5F9Z6M3;A0A1B0GTN0;A0A1B0GUN6;A0A1B0GUB6;A0A1W2PQ56;A0A1B0GWE1;Q59GD8;Q01668-4;Q01668;A0A1B0GWF7 Q01668-2 CACNA1D Voltage-dependent L-type calcium channel subunit alpha-1D 1 5268670.0 557070.0 2398500.0 2313100.0 True False 539386.117774701 3356233.5580122606 1707229.7184874394 1.0 6.222320981968882 3.165134700779491 19.040958865726083 -9.49847897107585 9.31542083335216 0.9999656569417431 4.693727841374191 0.6605989606398706 1.2480910730826604 0.0 0.0 1.2084589850786482 0.4028196616928827 3.173372317619347e-10 9.49847897107585 3.6937621844324475 CTDEAK(ub)SNPEECR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CTDEAKSNPEECR 13 1 Q01668-2;Q01668-3;A0A5F9Z6M3;A0A1B0GTN0;A0A1B0GUN6;A0A1B0GUB6;A0A1W2PQ56;A0A1B0GWE1;Q59GD8;Q01668-4;Q01668;A0A1B0GWF7 Q01668-2 CACNA1D Voltage-dependent L-type calcium channel subunit alpha-1D 1 45480500.0 1877300.0 4253200.0 39350000.0 True False 2571388.5421249303 4065279.560548438 30056340.4386889 1.0 1.5809666621556127 11.68875879560819 21.294116190170467 -6.9187172700323805 0.8341899352378359 0.7665010253901904 13.271566424113585 0.9938170320717422 0.3858880698984641 0.09893234916818743 0.1095700965035582 0.3302433555551577 0.9774174795868737 1.205820685999751e-07 6.9187172700323805 12.505065398723394 up CTESEEEEVTK(ub)GK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CTESEEEEVTKGK 13 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 7973100.0 2249300.0 2066100.0 3657700.0 True False 2948854.0822521825 1757845.9335947204 3279236.2911359067 1.0 0.5961115350448838 1.1120374897056267 21.491723004806392 -6.697844256501098 1.8382789577472616 0.7486809244987884 1.1104573519541963 0.40750996348648627 0.17055347563737716 0.4000075130797436 2.626366309343985 0.07405531692925656 0.19097886614219786 2.005190985314598e-07 6.697844256501098 0.36177642745540783 CTESEEEEVTK(ub)GK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CTESEEEEVTKGK 13 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 8278000.0 2249300.0 1530600.0 4498100.0 True False 3080926.995046931 1462973.0309826578 3435741.4212774197 1.0 0.47484832757628287 1.115164827599261 21.554933066329284 -6.688727585742822 1.870695046172877 0.6703761897549563 1.112933157920093 0.36457902649382223 0.2221592471361789 0.41941290082442056 2.8446170032865314 0.09503454281451483 0.24789630047246727 2.0477286861363172e-07 6.688727585742822 0.4425569681651367 CTESEEEEVTK(ub)GK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CTESEEEEVTKGK 13 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 6186980.0 1216200.0 925980.0 4044800.0 True False 1011324.1867953741 920991.5619473619 4890548.978957839 1.0 0.9106788643765625 4.8357876166837555 19.94781410633896 -6.90169356089039 0.9504977388805668 0.8443048006020422 5.262264980502343 0.9873902462201267 0.20545428703188923 0.11016945004288566 0.1704719153481147 0.16158577937558818 0.4241066207338064 1.2540257060450696e-07 6.90169356089039 4.417960179900302 up CTGGEVGATSALAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CTGGEVGATSALAPK 15 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 25186500.0 2451600.0 13706000.0 9028900.0 False True 3214071.3413281706 11661118.225569565 8094676.039324434 1.0 3.628145422792877 2.518511625812083 21.61597052155998 -10.498337346867615 6.562014244207754 0.9989413543060299 3.07332852430248 0.8231639811626061 0.45300610065833435 0.007017842735364496 0.0005365110262764425 0.43873233681778545 0.14620709029834084 3.1744073287649645e-11 10.498337346867615 2.0743871699964505 CTGGEVGATSALAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CTGGEVGATSALAPK 15 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 14845400.0 6385600.0 1650200.0 6809600.0 False True 6182892.623300722 2309133.4656793154 5025961.476378912 1.0 0.3734713840860122 0.8128818956742314 22.5598505202279 -10.279985884487457 5.820250105094802 1.0000262267001518 0.5931766398802104 0.533343459987346 0.17938859016775088 6.105347048866574e-05 7.552725399503067e-06 0.17370343085923176 0.05789741851827595 5.2482451790761636e-11 10.279985884487457 -0.40684958681994143 CTGGEVGATSALAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CTGGEVGATSALAPK 15 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 24558600.0 2451600.0 11253000.0 10854000.0 False True 3358022.7719988707 10755805.25130526 8290508.7451468585 1.0 3.203017365157069 2.4688661477456018 21.67918058308287 -10.128455255457666 5.50642673218171 0.9999708417390235 2.835941756451741 0.8929158831233077 0.29971597945162287 0.0001072875378938981 1.6982262583876522e-05 0.29020331837304825 0.096732916417158 7.439517069021398e-11 10.128455255457666 1.8359709147127172 CTGHSAEHTQCGK(ub)PQESTGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CTGHSAEHTQCGKPQESTGR 20 1 Q96RL1;Q96RL1-3 Q96RL1 UIMC1 BRCA1-A complex subunit RAP80 1 3259710.0 730120.0 457790.0 2071800.0 True False 1107645.4189218213 376093.7977704043 1662307.8218978017 1.0 0.33954349591089616 1.5007580887355514 20.079064686962365 -6.752450497917459 1.6410912851839579 0.6127874276231668 1.503460242325404 0.6593332022033642 0.2775661392822497 0.29578403428930905 1.5680847232012383 0.13357729841316238 0.32341946571242813 1.7682737589667523e-07 6.752450497917459 0.8906728147022371 CTGHSAEHTQCGK(ub)PQESTGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CTGHSAEHTQCGKPQESTGR 20 1 Q96RL1;Q96RL1-3 Q96RL1 UIMC1 BRCA1-A complex subunit RAP80 1 9811320.0 730120.0 1050800.0 8030400.0 True False 945154.732816836 992322.0562725639 6568949.598862195 1.0 1.0499043403350006 6.950131413175931 19.850191009054814 -6.908753465153202 0.9041899731255031 0.8100376202692183 7.692629498532946 0.990442403748229 0.27307448828325653 0.10524787329766577 0.1432844134759322 0.22220088143344993 0.6081982830897572 1.2338050254407396e-07 6.908753465153202 6.882591878263727 up CTK(ub)EEAIEHNYGGHDDDLSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CTKEEAIEHNYGGHDDDLSVR 21 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 11555200.0 2333900.0 3573100.0 5648200.0 True False 3021279.5580469156 3374253.8439926715 4620285.555426061 1.0 1.1168294026302994 1.5292479450040735 21.526728251684617 -6.947748499351827 0.5830471904401026 0.9951244032355671 1.6714585514572085 0.9990124704007589 0.007134088441139633 0.08440281279847268 0.03980403195546241 0.007450250633316591 0.03448068323600028 1.1278504071190083e-07 6.947748499351827 0.6763341482216414 CTK(ub)EEHLCTQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CTKEEHLCTQR 11 1 J3KN67;P06753-7;P06753-2;P06753-5;A0A087WWU8 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 1 62955000.0 19960000.0 23504000.0 19491000.0 True False 30280779.271461647 19309527.56240982 15638595.306791231 1.0 0.6376826497529484 0.5164528682235713 24.851898997560507 -13.999999999999998 0.1529442041880975 2.7603757698906244 0.3874875295032242 0.9995567111306888 0.004325064530889562 11.970037925859026 0.12331056286094813 6.257509817209157 0.11658792043151435 1.0000000000000041e-14 13.999999999999998 -2.3728882403874003 CTK(ub)EEHLCTQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CTKEEHLCTQR 11 1 J3KN67;P06753-7;P06753-2;P06753-5;A0A087WWU8 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 1 52206800.0 19960000.0 23565000.0 8681800.0 True False 25838613.470421392 22253587.034700185 7101801.482790616 1.0 0.8612531419371575 0.2748522667797312 24.623025319652957 -6.943611398843408 0.6250624353250727 1.0064014903946452 0.09836645563254434 0.998599702499341 0.011760585974595955 0.08615701312211463 0.04739208478103819 0.011789697671681141 0.04972371134822888 1.1386456757448157e-07 6.943611398843408 -0.9080350347621009 down CTK(ub)IINADSEDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CTKIINADSEDPK 13 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 28078960.0 6707260.0 12194700.0 9177000.0 True False 8793282.813198244 10375298.294568306 8227452.071999955 1.0 1.1799118162099302 0.9356519341844655 23.0679704393735 -6.709325278744156 1.797341504037177 1.1106805516245768 0.9362305974482739 0.4619988165031156 0.07582183474208491 0.37644428746098696 2.37006105959524 0.03357420956657387 0.08537269489806627 1.9528762387558251e-07 6.709325278744156 -0.17444995417630293 CTK(ub)IINADSEDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 CTKIINADSEDPK 13 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 34120010.0 8423110.0 12816700.0 12880200.0 True False 8155722.983627309 17934475.148207553 9506489.222282616 1.0 2.1990049421996285 1.1656218880125016 22.959381343092822 -6.61008572579684 2.1535825885030357 1.8010325853573 1.1693354611972446 0.05054555608068234 0.516924231057609 0.6124621096507991 5.382982438998026 0.19821525623198044 0.5738160593362406 2.454224426198591e-07 6.61008572579684 -0.6316971241600553 CTK(ub)IINADSEDPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CTKIINADSEDPK 13 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 99368400.0 1767100.0 25797300.0 71804000.0 True False 2680819.8923146245 21193570.25977514 57611907.92718885 1.0 7.905630035248871 21.490406010620365 21.354242866155705 -6.960366894378708 0.43023113927394585 0.46171295846502364 29.45547647054885 0.9997835673142695 0.12522589377215887 0.07957031774703832 0.020648910666461143 0.17718147329260725 1.1278965901760916 1.0955522764688198e-07 6.960366894378708 28.993763512083824 CTK(ub)IINADSEDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CTKIINADSEDPK 13 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 23601560.0 6707260.0 9621400.0 7272900.0 True False 9187115.278886106 9196294.734284945 5555190.810077258 1.0 1.0009991662366462 0.6046719390627695 23.13118050089639 -6.906331182388783 0.9203677396195858 1.0137397904872922 0.5572795382415778 0.9894615797694554 0.019155285928621237 0.1068940733740839 0.15230155054934408 0.015403586743452904 0.04151336260366773 1.2407058147319404e-07 6.906331182388783 -0.4564602522457144 CTK(ub)IINADSEDPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CTKIINADSEDPK 13 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 31611910.0 8423110.0 11826100.0 11362700.0 True False 7004189.172042417 11762390.45200295 13738588.034811178 1.0 1.6793364889333855 1.9614815787171285 22.7397866185271 -10.524293716980521 0.18670041969108236 4.160178691064024e-17 2.2301535094715628 0.9994647097795277 0.009336277396066694 2.294941435975606 0.09658426406614669 1.2477048985090444 0.1908711811966704 2.9902416272424116e-11 10.524293716980521 2.2301535094715628 CTK(ub)IINADSEDPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CTKIINADSEDPK 13 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 73227200.0 1767100.0 26199400.0 45260700.0 True False 2287545.784748581 24741380.35887646 37023717.013999574 1.0 10.81568750397524 16.184907537520072 21.125369188248154 -8.414302087580278 0.4201014284378785 6.177305399294157e-15 17.309442721723393 0.9961090926558188 0.3921762782516107 0.16586135836094754 0.1300701604025241 1.3657928637347883 1.286161951683954 3.852103189526615e-09 8.414302087580278 17.309442721723386 CTLLLMLDHQPPQYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CTLLLMLDHQPPQYK 15 0 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925;J3QWB6 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 0 11013600.0 2985100.0 2523400.0 5505100.0 False True 4088772.139294271 2411907.8442320875 4204908.761093424 1.0 0.5898856091913175 1.028403789167669 21.96323623535062 -11.786639056106985 17.279614230453937 0.901800981158096 0.8282302380379546 0.0 0.20524981834861525 0.0 0.0 0.0 0.05959064919659776 1.6344097481037415e-12 11.786639056106985 -0.07357074312014145 CTVFHGAQVEDAFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CTVFHGAQVEDAFR 14 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 12190700.0 2083600.0 4586800.0 5520300.0 False True 2731619.7776111034 3902467.3192063686 4949112.31045672 1.0 1.428627567859833 1.8117866736141774 21.3813252538563 -6.972452617229328 0.19071252518155143 0.7427213684142181 2.508167961073312 0.9999957284344383 0.000685285235045676 0.07551459156996784 0.0060892233485686995 0.013445301616532054 0.04168642639448252 1.0654851048000564e-07 6.972452617229328 1.7654465926590936 CTVFHGAQVEDAFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CTVFHGAQVEDAFR 14 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 11074400.0 2083600.0 3924700.0 5066100.0 False True 2853963.2271728064 3751293.7767526703 3869591.5196046145 1.0 1.314415596191398 1.355865935048473 21.44453531537919 -12.397434185807052 0.3131109605080321 8.899403870779926e-11 1.3652970948993968 0.9995639007760999 0.0033181045621116607 6.635019210031845 0.17240443793025387 4.268474359762542 0.014180171447436303 4.0046615148611086e-13 12.397434185807052 1.3652970948104026 CTVIAAANPIGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CTVIAAANPIGGR 13 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 26454100.0 4173400.0 13375000.0 8905700.0 False True 5471367.815263092 11379502.135341655 7984223.593506589 1.0 2.079827662764155 1.4592737799921913 22.38347011415437 -10.567785516158581 6.344695852084067 0.9986069514725912 1.769550721378075 0.6721820805728228 0.2533400617823666 0.0049990691598478755 0.00034054689892417896 0.24563733199149215 0.0817651533508554 2.7052940905231036e-11 10.567785516158581 0.7709437699054839 CTVIAAANPIGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CTVIAAANPIGGR 13 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 6120300.0 2199900.0 1027200.0 2893200.0 False True 2130065.3786643767 1437366.316777235 2135384.125860471 1.0 0.6747991546055325 1.0024969877682484 21.022466281478266 -10.99284404179933 10.122855820324421 1.1365637483207713 0.8386480711860507 0.24428549356336615 0.13378208017739093 0.06918040536780519 4.8904376699274975e-05 0.021733459636293306 0.04317798071233505 1.0166137004529654e-11 10.99284404179933 -0.29791567713472067 CTVIAAANPIGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CTVIAAANPIGGR 13 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 10405100.0 4173400.0 6231700.0 0.0 False True 5716418.761894312 5956362.8885238655 0.0 1.0 1.0419745537589065 0.0 22.446680175677262 -6.994011390626742 1.1310494390470849 1.0361434083786372 2.08886657533295e-19 0.9822604448547458 0.06414466216254515 0.09336378510010403 0.23423307897401816 0.0477110880298185 0.08782740283704762 1.0138847933318184e-07 6.994011390626742 -1.0361434083786372 down CTYLVLDEADR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CTYLVLDEADR 11 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 14230200.0 2566400.0 6236700.0 5427100.0 False True 3364575.253052953 5306208.670466199 4865555.752419194 1.0 1.5770812870514468 1.4461129225759712 21.681992958560517 -10.041474688914303 4.5271234365869475 0.9999772402646074 1.511597104846939 0.9531510714429331 0.05346761102295165 18501207.281275593 0.811996370603218 4516.512075135544 0.018303385390181615 9.089192701810718e-11 10.041474688914303 0.5116198645823316 CTYLVLDEADR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CTYLVLDEADR 11 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 15697000.0 2566400.0 6891000.0 6239600.0 False True 3515267.434352221 6586532.83451031 4765934.988595756 1.0 1.8736932416989915 1.3557816233330204 21.74520302008341 -10.403353100147926 5.20928795812626 0.9995207256950462 1.6147374325160277 0.6525945142145331 0.2114365328093562 0.0011777908060388994 0.00013489907686315824 0.20487529966471374 0.0682408475291953 3.950453005921004e-11 10.403353100147926 0.6152167068209815 CVEENNGVAK(ub)HISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CVEENNGVAKHISR 14 1 Q15758;M0QXM4;Q15758-3;Q15758-2;M0QX44 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 1 37814000.0 4272800.0 14177200.0 19364000.0 True False 5601682.177854061 12062017.02229276 17360399.032604005 1.0 2.1532847882693655 3.0991403084661564 22.417428700997732 -6.973392000102029 0.1573059947913194 0.006586519281868531 5.2708744238468626 0.9999982043351539 0.001150214012612531 0.0752166828985833 0.004842712080264891 0.04492815716905989 0.1146523399853285 1.0631829416271648e-07 6.973392000102029 5.264287904564994 CVEENNGVAK(ub)HISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CVEENNGVAKHISR 14 1 Q15758;M0QXM4;Q15758-3;Q15758-2;M0QX44 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 1 47351800.0 12889800.0 16907000.0 17555000.0 True False 19554768.9706055 13889813.755006066 14085246.555370176 1.0 0.7103031376072543 0.7202972623477656 24.221017155693765 -10.001732235557595 5.105728379443348 1.0000022777343638 0.7153001999754988 0.9990766291892524 0.004080084346994969 1.0578575573060438e-07 2.0684573617774976e-08 0.003950556287795027 0.0013168415595815185 9.960193242060254e-11 10.001732235557595 -0.284702077758865 CVEENNGVAK(ub)HISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CVEENNGVAKHISR 14 1 Q15758;M0QXM4;Q15758-3;Q15758-2;M0QX44 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 1 21844300.0 4272800.0 10620500.0 6951000.0 True False 5852569.628078309 10151251.19270307 5309316.960338667 1.0 1.7344947327070475 0.9071770688325806 22.480638762520623 -6.672492059857511 1.9288941747054615 1.4678234298300015 0.9105068468241234 0.29002100576574263 0.3118202524546851 0.4553942037903226 3.268997990137973 0.1300448546310459 0.3462772584412065 2.1257292092580384e-07 6.672492059857511 -0.557316583005878 CVEENNGVAK(ub)HISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CVEENNGVAKHISR 14 1 Q15758;M0QXM4;Q15758-3;Q15758-2;M0QX44 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 1 36677800.0 12889800.0 11422000.0 12366000.0 True False 16686100.195943749 10786355.659255058 10115514.885874914 1.0 0.6464275973769551 0.6062240288077565 23.992143477786215 -13.999999999999998 0.3068845518198324 4.356185784720409 0.5970201239467395 0.99966512693446 0.0032374519290659723 17.05075023323947 0.17614978828593322 36.478290048387606 0.014112136877920456 1.0000000000000041e-14 13.999999999999998 -3.759165660773669 CVGFTEADVSVLQAANILLPSNTHK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CVGFTEADVSVLQAANILLPSNTHKDR 27 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 23330800.0 7311900.0 6297100.0 9721800.0 True False 9465398.689096903 5946660.849404216 7952532.15409175 1.0 0.6282525485433713 0.8401687467483214 23.174231843839436 -10.172864959591966 5.352256411257596 1.000009942572258 0.7342106476457737 0.677150751195154 0.08651442563902659 1.0264590789330934e-05 1.586450319155193e-06 0.08377036428619576 0.02792241080885073 6.716376608387078e-11 10.172864959591966 -0.26579929492648424 CVHIWNTQTGALVHSYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CVHIWNTQTGALVHSYR 17 0 Q9BZK7;A0A0D9SFI2 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 55058900.0 15340700.0 16449900.0 23268300.0 False True 20111806.259550117 13995639.041207982 20860719.52129415 1.0 0.6958916996608465 1.0372374938421263 24.261539321422863 -6.671786731377263 1.9317774103916676 0.8061805488262059 1.0358470420588899 0.2867205069897223 0.12912681976433138 0.45699456917276315 3.289749398804734 0.05378966867632322 0.14333993630441644 2.1291843660595506e-07 6.671786731377263 0.22966649323268395 CVHIWNTQTGALVHSYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CVHIWNTQTGALVHSYR 17 0 Q9BZK7;A0A0D9SFI2 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 14366500.0 9109400.0 2064200.0 3192900.0 False True 8820227.083233463 2888445.824660793 2356583.7050531963 1.0 0.32747975731276746 0.2671794822077621 23.072384368830036 -13.999999999999998 0.34135123710823545 8.842825998552444 0.25786907865334147 0.9997378907710064 0.005377524032467523 19.82863512067602 0.1874992173253717 112.29021650546476 0.018541317260252443 1.0000000000000041e-14 13.999999999999998 -8.584956919899103 CVHIWNTQTGALVHSYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CVHIWNTQTGALVHSYR 17 0 Q9BZK7;A0A0D9SFI2 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 36539900.0 9421600.0 18879900.0 8238400.0 False True 14293256.0112226 15510634.335668009 6610076.628981004 1.0 1.0851715188960138 0.46246122113750615 23.768831264771553 -6.872347330874908 1.1215328117190293 1.0489321965086473 0.42431622668056723 0.9669737654564017 0.05009874840026746 0.13462772358691566 0.3150557581729503 0.03461406853408715 0.0823055518732691 1.3416915022278055e-07 6.872347330874908 -0.6246159698280801 down CVHIWNTQTGALVHSYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CVHIWNTQTGALVHSYR 17 0 Q9BZK7;A0A0D9SFI2 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 57379800.0 15340700.0 21627700.0 20411400.0 False True 21012571.35682945 20672116.700760234 15590647.705978487 1.0 0.9837975728773165 0.7419676269611456 24.324749382945754 -6.9204867210227246 0.821117188363409 1.005242796679177 0.7025315041091321 0.9943148749057625 0.008897488424574154 0.09788622472575298 0.10413923080067722 0.0076859102793121435 0.023130879098999003 1.2009177916858394e-07 6.9204867210227246 -0.3027112925700449 CVHIWNTQTGALVHSYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CVHIWNTQTGALVHSYR 17 0 Q9BZK7;A0A0D9SFI2 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 14396700.0 9109400.0 1020200.0 4267100.0 False True 7574869.7148444215 1014703.9801061552 5159330.881158773 1.0 0.13395662477437026 0.6811115009738143 22.852789644264313 -10.041411386704803 6.372101264456029 1.0000004617848024 0.40753406303937983 0.6098793343499554 0.2233750428274134 1.465487883886908e-06 2.2051843780742123e-07 0.21628212600830385 0.07209398506907487 9.090517627498029e-11 10.041411386704803 -0.5924663987454226 CVHIWNTQTGALVHSYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CVHIWNTQTGALVHSYR 17 0 Q9BZK7;A0A0D9SFI2 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 39829200.0 9421600.0 17376600.0 13031000.0 False True 12196446.927501114 16409576.934740977 10659491.709351128 1.0 1.3454391293041175 0.873983363574158 23.539957586864002 -6.710272859496469 1.7939175477640814 1.2123016083345075 0.8750652420462691 0.46657834497192263 0.14555907506525387 0.37450794946805427 2.349470143434615 0.06456237516249368 0.16398384668228191 1.9486199318444173e-07 6.710272859496469 -0.3372363662882384 CVK(ub)DQNGNHVVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CVKDQNGNHVVQK 13 1 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72;H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;H0YDK8;H0YC97 A0A0C4DG68;H0YEH2 PUM2;PUM1 Pumilio homolog 2;Pumilio homolog 1 1 9018900.0 1383400.0 1387000.0 6248500.0 True False 2098718.940087173 1139479.0133195375 5013481.23618516 1.0 0.5429402630121629 2.388829271239587 21.00107754353292 -6.841198620135669 1.2769862146980608 0.7568960661452988 2.4509305516363065 0.926467886815402 0.2128483361115102 0.16740562049563404 0.5297882100833119 0.13067874824979117 0.30113328818302443 1.441455965624164e-07 6.841198620135669 1.6940344854910077 up CVK(ub)DQNGNHVVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CVKDQNGNHVVQK 13 1 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72;H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;H0YDK8;H0YC97 A0A0C4DG68;H0YEH2 PUM2;PUM1 Pumilio homolog 2;Pumilio homolog 1 1 3792340.0 952940.0 1212900.0 1626500.0 True False 1305267.6702351947 1159310.0674760658 1242354.1988189965 1.0 0.8881780296199101 0.9518003296558614 20.315914258818772 -10.23447284921297 4.9730792860190665 1.0000124773245238 0.9199891796378129 0.6783234510603688 0.0259736952253084 3.5937616994621106e-06 5.532431098954043e-07 0.025152843509767698 0.008382974087221134 5.828102092018503e-11 10.23447284921297 -0.0800232976867109 CVK(ub)LDRPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CVKLDRPR 8 2 P10644;P31321;H7BYW5 P10644;P31321 PRKAR1A;PRKAR1B cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed;cAMP-dependent protein kinase type I-beta regulatory subunit 1 180379000.0 34288000.0 69217000.0 76874000.0 True False 44951900.045464344 58890093.40575287 68919815.90747781 1.0 1.310069059287626 1.5331902731090858 25.421878761669507 -6.974692280737039 0.09282740135298909 0.3776639907804831 2.4712315644961182 0.9999998128355974 9.441130526531471e-05 0.07480745597188461 0.0027125035633022354 0.022200722703582036 0.03863939820436662 1.060004525137571e-07 6.974692280737039 2.093567573715635 CVK(ub)LDRPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CVKLDRPR 8 2 P10644;P31321;H7BYW5 P10644;P31321 PRKAR1A;PRKAR1B cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed;cAMP-dependent protein kinase type I-beta regulatory subunit 1 228739000.0 70768000.0 82778000.0 75193000.0 True False 68521508.57644476 115831687.08156745 55497697.55835284 1.0 1.6904427454678987 0.8099310524729306 26.030053578502645 -6.697529866210272 1.8397204197767882 1.4297492752463954 0.8126636727019071 0.40601142535704704 0.291574155176684 0.4005920789701006 2.634183533794507 0.1265248749087569 0.3263793545831995 2.0066430894501397e-07 6.697529866210272 -0.6170856025444883 CVK(ub)LDRPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CVKLDRPR 8 2 P10644;P31321;H7BYW5 P10644;P31321 PRKAR1A;PRKAR1B cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed;cAMP-dependent protein kinase type I-beta regulatory subunit 1 251607000.0 33341000.0 62116000.0 156150000.0 True False 50580734.55359731 51030914.48547685 125286884.05702385 1.0 1.008900225270602 2.4769684577092295 25.59208465275751 -6.908230049768713 0.9077042500982999 0.9519622954085638 2.65968018432794 0.9902363064766541 0.06859105371125684 0.10560008631404433 0.14520243532352067 0.05566953246182354 0.15185220631358226 1.2352929141254892e-07 6.908230049768713 1.707717888919376 up CVK(ub)LDRPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CVKLDRPR 8 2 P10644;P31321;H7BYW5 P10644;P31321 PRKAR1A;PRKAR1B cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed;cAMP-dependent protein kinase type I-beta regulatory subunit 1 155310000.0 34288000.0 56056000.0 64966000.0 True False 46965200.19835918 53579260.567596845 49622368.816769026 1.0 1.1408289614715355 1.0565773936273497 25.4850888231924 -10.21712966431887 4.105941582723911 0.9999397563510996 1.0987031775589895 0.6466399100146445 0.03439555857306622 24219939.835747834 1.4980821512614857 13794.698884525367 0.011774514563147466 6.065552075317694e-11 10.21712966431887 0.09876342120788995 CVK(ub)LDRPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CVKLDRPR 8 2 P10644;P31321;H7BYW5 P10644;P31321 PRKAR1A;PRKAR1B cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed;cAMP-dependent protein kinase type I-beta regulatory subunit 1 211158000.0 70768000.0 62852000.0 77538000.0 True False 58846727.55396735 62513403.800854735 93750837.30479464 1.0 1.062308923525522 1.5931359516774712 25.81045885393692 -6.928943855310794 0.75540298472102 0.9916040181171363 1.6992408343981968 0.9963268119771651 0.01612984412711544 0.09318942384228895 0.0803914146310895 0.014603931309446106 0.048312408778533315 1.1777582218178044e-07 6.928943855310794 0.7076368162810606 CVK(ub)LDRPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CVKLDRPR 8 2 P10644;P31321;H7BYW5 P10644;P31321 PRKAR1A;PRKAR1B cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed;cAMP-dependent protein kinase type I-beta regulatory subunit 1 110292000.0 33341000.0 47809000.0 29142000.0 True False 43160581.7493647 45148387.12251142 23838455.022170976 1.0 1.0460560375365187 0.5523200581633001 25.36321097484996 -6.884064092178881 1.0568293873611485 1.0304251985816568 0.5144772678622173 0.9768202574219981 0.033904173008849986 0.12409292059179589 0.2510250734311323 0.02461448413152549 0.060191229630606725 1.3059781406649847e-07 6.884064092178881 -0.5159479307194396 CVLK(ub)IGEHTPSALAIMENANVLAR ddPTM_RPMI8226_Bortezomib_8h_R1 2 CVLKIGEHTPSALAIMENANVLAR 24 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BR04;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 306877300.0 77015500.0 34897800.0 194964000.0 True False 116838144.08723706 28670014.932244074 156429279.94424325 1.0 0.24538232061301524 1.338854542463851 26.79993610610505 -6.721006630675317 1.7554767639703788 0.5414051284646612 1.3372757030766174 0.5173850393865402 0.31750640172450356 0.35335271442104343 2.128611762138078 0.14357373710860932 0.3600272160907132 1.9010492550631536e-07 6.721006630675317 0.7958705746119562 CVLK(ub)IGEHTPSALAIMENANVLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 CVLKIGEHTPSALAIMENANVLAR 24 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BR04;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 301657600.0 77015500.0 120278200.0 104363900.0 True False 99698082.95246676 113584612.43696484 85370741.06404331 1.0 1.1392858224878686 0.8562927042914725 26.5710624281975 -6.772873642093162 1.5633862345463383 1.0795984907190381 0.8545232574965578 0.7414253587750093 0.05875040726943955 0.2618239081918682 1.2633189109775054 0.029613152240710844 0.07030936882106717 1.6870437991010635e-07 6.772873642093162 -0.22507523322248035 CVNNYQGMLK(ub)VACAEEWQESR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CVNNYQGMLKVACAEEWQESR 21 1 O75663;O75663-2 O75663 TIPRL TIP41-like protein 1 36248200.0 14604000.0 7324200.0 14320000.0 True False 22155335.695412114 6017139.285764211 11489645.723321028 1.0 0.2715887210415967 0.5185949732957683 24.40115085077077 -10.233282181137161 5.4776276199538705 1.0000381851707163 0.3950918471695188 0.8888460663956276 0.10083988021679567 4.702716756061703e-05 6.582397093901731e-06 0.0976439357419681 0.03254593139274579 5.844102424933883e-11 10.233282181137161 -0.6049463380011975 CVNNYQGMLK(ub)VACAEEWQESR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CVNNYQGMLKVACAEEWQESR 21 1 O75663;O75663-2 O75663 TIPRL TIP41-like protein 1 40845400.0 14604000.0 5196400.0 21045000.0 True False 18905165.887877453 4907215.77199729 17215025.939935103 1.0 0.2595700985170376 0.9105990416605592 24.172277172863218 -10.69266933701482 9.486890240168036 1.0005039034346226 0.5850845700890217 0.35131210180663164 0.26578145308083817 0.002835779391711613 9.186552833522022e-05 0.25762309525370497 0.08578059512607449 2.029227143773831e-11 10.69266933701482 -0.4154193333456009 CVNTTLQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CVNTTLQIK 9 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 51795000.0 18232000.0 18064000.0 15499000.0 False True 23902328.558939174 15368921.612920506 13895312.156906104 1.0 0.6429884676308125 0.5813371748548503 24.510647836258258 -13.999999999999998 0.24707343028434287 3.4466930720079003 0.55584880526601 0.9995372743524027 0.00396991579335074 13.883903160786648 0.1572949909064196 16.830095288856693 0.02892230078662437 1.0000000000000041e-14 13.999999999999998 -2.8908442667418903 CVNTTLQIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CVNTTLQIK 9 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 82062000.0 15466000.0 42669000.0 23927000.0 False True 23463052.716053385 35054383.575581394 19197817.962423343 1.0 1.4940248398111144 0.8182148416385829 24.483887395045716 -6.710732019475767 1.7923598393230784 1.3034932255947997 0.81975529596782 0.4685877352874662 0.2081569631734287 0.3736575147723525 2.340365111780312 0.09239873657409302 0.23454879284989308 1.946560832515446e-07 6.710732019475767 -0.4837379296269797 CVNTTLQIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CVNTTLQIK 9 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 52739000.0 18232000.0 12853000.0 21654000.0 False True 24972863.101274062 12285111.960812801 16539771.178128827 1.0 0.4919384658055504 0.6623097684496178 24.57385789778115 -10.236102591268255 5.529142453407174 1.0000252647685972 0.5771241171275632 0.891473286131535 0.06955379304861667 2.166317281084269e-05 2.992875239415446e-06 0.06734918670336179 0.02244839017855995 5.8062724257693605e-11 10.236102591268255 -0.42290114764103404 CVNTTLQIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CVNTTLQIK 9 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 12491100.0 10080000.0 2411100.0 0.0 False True 8381966.619714986 2398110.9257341186 0.0 1.0 0.28610361202030915 0.0 22.998857345425545 -8.834246117393802 0.4845108973959701 1.0884344537025945 3.9796441291312964e-23 0.995427382651037 0.028435766674205058 0.3992629202995035 0.19435175715328154 0.13405174786604174 0.05904967345109562 1.4647175411366207e-09 8.834246117393802 -1.0884344537025945 CVNTTLQIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CVNTTLQIK 9 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 53476000.0 15466000.0 22728000.0 15282000.0 False True 20021041.88043773 21463166.820482336 12500832.806561578 1.0 1.072030464181471 0.6243847288874591 24.255013717138166 -6.8656807243400095 1.1567762787030962 1.039842329533373 0.6002417236011764 0.9601747662180152 0.03916615868913767 0.14105936346900894 0.3555166439218368 0.026340819786996875 0.06193300021866263 1.362445929281046e-07 6.8656807243400095 -0.4396006059321965 CVQDAK(ub)GGSFYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CVQDAKGGSFYR 12 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 49175240.0 13655240.0 18694900.0 16825100.0 True False 17902151.877532274 15905693.792149452 15084200.049755523 1.0 0.8884794353751163 0.8425914467124277 24.093629677201232 -13.999999999999998 0.12200937511756596 1.5308358753064055 0.7712957800752942 0.9996831346444807 0.0011765696258647625 11.956520459020277 0.10775415065873027 1.5350256510674811 0.06327916848276362 1.0000000000000041e-14 13.999999999999998 -0.7595400952311113 CVQDAK(ub)GGSFYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CVQDAKGGSFYR 12 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 45359230.0 21453400.0 12752830.0 11153000.0 True False 20772373.559997447 17845101.524129886 8231694.717171933 1.0 0.8590785965112443 0.39628089170436354 24.30816273969066 -6.949400809769427 0.5653825328890605 1.0058907886404078 0.2271454847868922 0.9991534261737278 0.007503249646412782 0.08372722488200075 0.03696487431829306 0.00799175241569883 0.038517636730302236 1.1235675563999081e-07 6.949400809769427 -0.7787453038535156 down CVQDAK(ub)GGSFYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CVQDAKGGSFYR 12 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 130877500.0 45568900.0 59122700.0 26185900.0 True False 69131352.83283103 48571792.257236496 21010245.387312286 1.0 0.7026015008658903 0.3039177526023236 26.04283682226108 -7.099147089068478 0.34417400598485043 1.0451952150192294 3.385733899524756e-13 0.9999145515395387 0.0026361076618395016 0.07624304223976516 0.015392279651506136 0.0065840350914817235 0.034672055950306306 7.958897487685639e-08 7.099147089068478 -1.0451952150188908 down CVQDAK(ub)GGSFYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CVQDAKGGSFYR 12 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 52811940.0 13655240.0 21299600.0 17857100.0 True False 18703951.2469856 20358513.24364183 13639620.758518703 1.0 1.0884605597399046 0.7292373990077052 24.156839738724123 -6.841558740829468 1.2750546902435187 1.0470548368486257 0.7170469900745702 0.9271127300618726 0.0412571455904621 0.1669867954686924 0.5266668919899764 0.02536480601472636 0.05846497871385422 1.440261193451781e-07 6.841558740829468 -0.3300078467740555 CVQDAK(ub)GGSFYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CVQDAKGGSFYR 12 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 49077300.0 21453400.0 13460900.0 14163000.0 True False 17839452.64676524 13388383.459920563 17124417.8176869 1.0 0.7504929509341324 0.9599183426063247 24.088568015124935 -10.073284115482302 6.2960929614921115 1.0000002118665423 0.8552056469390132 0.3892599447401248 0.08549755812990266 2.542854911229223e-07 3.742165273236542e-08 0.08278277558264198 0.027594218231542015 8.447260445178608e-11 10.073284115482302 -0.14479456492752907 CVQDAK(ub)GGSFYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CVQDAKGGSFYR 12 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 70131100.0 45568900.0 5072600.0 19489600.0 True False 58989839.34730883 4790305.3508262355 15942692.78018336 1.0 0.08120560089378805 0.27026167483384883 25.81396314435353 -10.227835051309052 7.745173776490777 1.0000008620170686 0.1757336378638286 0.9620421603708006 0.0771818189878395 1.148874878836981e-06 1.1459055499124002e-07 0.07473105282513635 0.02491032496415815 5.917863569245015e-11 10.227835051309052 -0.82426722415324 CVQK(ub)DIQPYMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CVQKDIQPYMR 11 1 P30279;A0A3B3IT44;P30279-2 P30279 CCND2 G1/S-specific cyclin-D2 1 9441600.0 2283400.0 1224700.0 5933500.0 True False 3127634.6865647864 1170588.704458684 4532129.5042683715 1.0 0.374272836110662 1.4490597395331362 21.576640582397978 -6.7488771270938575 1.653945326808218 0.6315720902266846 1.4510216109187764 0.6441515875832869 0.2629215586956729 0.3020058724355023 1.6250871055461789 0.12559403286167672 0.3052752681535339 1.7828831188783567e-07 6.7488771270938575 0.8194495206920918 CVQSNIVLLTQAFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CVQSNIVLLTQAFR 14 0 O94925-3;O94925 O94925-3 GLS Glutaminase kidney isoform, mitochondrial 0 4890200.0 1259300.0 2075600.0 1555300.0 False True 1650954.495078546 1765928.5706254328 1394372.4754910662 1.0 1.0696409718678628 0.8445856500876648 20.654868925414682 -6.823597559096059 1.3562084309042046 1.0374058367371162 0.8392816982799196 0.8924640529293744 0.030850178657348574 0.18884758909794194 0.6815100066387401 0.017870676997783812 0.04115547542746965 1.5010751691730725e-07 6.823597559096059 -0.19812413845719656 CVQSNIVLLTQAFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CVQSNIVLLTQAFR 14 0 O94925-3;O94925 O94925-3 GLS Glutaminase kidney isoform, mitochondrial 0 9047600.0 1259300.0 3431100.0 4357200.0 False True 1724897.2413028944 3279502.6568695875 3328119.0993508277 1.0 1.9012742199021826 1.9294593438139804 20.718078986937574 -11.056276320800952 0.5923815985102626 9.461207834837168e-12 1.926188053962184 0.9999161706463017 0.003952217512927491 3.0382607127848194 0.2924457944459331 4.111338966041176 0.004951113005584875 8.784634147421769e-12 11.056276320800952 1.926188053952723 CVSTLLDLIQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CVSTLLDLIQTK 12 0 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7EJ01;H7C034;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 8075000.0 2204200.0 3102400.0 2768400.0 False True 2889727.545503164 2639534.0130604845 2481952.5243679504 1.0 0.9134196810934591 0.8588880734553086 21.462502045689963 CVSTLLDLIQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CVSTLLDLIQTK 12 0 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7EJ01;H7C034;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 8895600.0 2204200.0 3384500.0 3306900.0 False True 3019152.3062652615 3234961.5989551814 2525878.327743336 1.0 1.0714800946749452 0.836618385399671 21.525712107212854 -6.825040766428248 1.3498750520362557 1.0383440245517441 0.8309131071861884 0.8955952574154367 0.03176186935860925 0.1870123088580412 0.6681585802767523 0.01848292623331339 0.04255495983998332 1.4960952137831724e-07 6.825040766428248 -0.20743091736555574 CVTYTSLYK(ub)SAYLHPQQFDCEPGVLGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CVTYTSLYKSAYLHPQQFDCEPGVLGSK 28 1 Q12899 Q12899 TRIM26 Tripartite motif-containing protein 26 1 38240100.0 5122100.0 12603000.0 20515000.0 True False 7770600.175669026 10353896.182311561 16460201.257956073 1.0 1.3324448495923444 2.1182663997429128 22.889594601293325 -6.956651296776923 0.4803118030565008 0.9811933008306901 2.502297962609877 0.9996251185154885 0.009078198983347304 0.080919817349292 0.02572188810105598 0.01108687185173314 0.0648228763892387 1.1049654614137535e-07 6.956651296776923 1.521104661779187 up CVTYTSLYK(ub)SAYLHPQQFDCEPGVLGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CVTYTSLYKSAYLHPQQFDCEPGVLGSK 28 1 Q12899 Q12899 TRIM26 Tripartite motif-containing protein 26 1 34373100.0 5122100.0 15556000.0 13695000.0 True False 6630659.421685644 14690294.925176999 11202650.522566466 1.0 2.2155104026504855 1.6895228377931875 22.660720923385774 -10.568772695419462 5.685644086659561 0.9966343605764834 1.9525166202218365 0.8138679923142444 0.21473352415824318 0.00917558607064375 0.0006959209964415168 0.20824301252784586 0.06930494691144187 2.6991517668325034e-11 10.568772695419462 0.9558822596453531 CVVSEAGK(ub)ALDMSYDHKPEDEVELAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CVVSEAGKALDMSYDHKPEDEVELAR 26 2 O15355 O15355 PPM1G Protein phosphatase 1G 1 13643800.0 3152800.0 6958700.0 3532300.0 True False 4133351.3317586267 5920489.084800153 3166811.480214168 1.0 1.4323701542886143 0.7661607315792285 21.97888056624343 -6.731539130443179 1.7177743757661004 1.2597512535358466 0.7664551059900345 0.5663442498438632 0.1817365496617382 0.33334731792875893 1.927731975527592 0.08381965427573657 0.20761894246721638 1.855499619205498e-07 6.731539130443179 -0.4932961475458121 CVVSEAGK(ub)ALDMSYDHKPEDEVELAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CVVSEAGKALDMSYDHKPEDEVELAR 26 2 O15355 O15355 PPM1G Protein phosphatase 1G 1 18948300.0 7816500.0 5871200.0 5260600.0 True False 7568369.486035785 8215600.777903519 3882691.0453828266 1.0 1.0855179299929694 0.5130155250145604 22.851551091756697 -6.868873200842368 1.1399572964391544 1.0480572547358251 0.48018546221276764 0.9635499167603423 0.04814064152040198 0.1379442327579618 0.33572397986980845 0.032794291946612944 0.07749827453415359 1.3524673798433624e-07 6.868873200842368 -0.5678717925230574 CVVSEAGK(ub)ALDMSYDHKPEDEVELAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CVVSEAGKALDMSYDHKPEDEVELAR 26 2 O15355 O15355 PPM1G Protein phosphatase 1G 1 48327100.0 15254100.0 15602000.0 17471000.0 True False 23141584.924088318 12817701.201017624 14017849.19218868 1.0 0.5538817346808232 0.6057428321427265 24.46398433953937 -10.403339676775646 5.373995068318258 1.0002612123570114 0.5798122834117689 0.9887040101833737 0.021172204380422638 6.630161898644572e-05 7.361269185206736e-06 0.020512425937114893 0.00683329958065337 3.9505751102145326e-11 10.403339676775646 -0.42044892894524244 CVVSEAGK(ub)ALDMSYDHKPEDEVELAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 CVVSEAGKALDMSYDHKPEDEVELAR 26 2 O15355 O15355 PPM1G Protein phosphatase 1G 1 18825000.0 7816500.0 5998200.0 5010300.0 True False 6499766.079662924 5965886.506050524 6057930.564990221 1.0 0.9178617250114813 0.9320228590910126 22.631956367190973 -10.186945901988178 7.342224099762024 1.000000080495186 0.9249422920530325 0.9739969222639385 0.005781258778998177 7.619061330176545e-09 8.40684761210356e-10 0.005597685748448541 0.0018658932475979517 6.502106789712128e-11 10.186945901988178 -0.0750577884421536 CVVSEAGK(ub)ALDMSYDHKPEDEVELAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CVVSEAGKALDMSYDHKPEDEVELAR 26 2 O15355 O15355 PPM1G Protein phosphatase 1G 1 51030900.0 15254100.0 8188500.0 27588300.0 True False 19746733.153264266 7732802.776729997 22567512.47986272 1.0 0.3915990921998008 1.1428478981664956 24.23511066163182 -6.691240505392841 1.8618553479974953 0.619020041260346 1.1403023284254437 0.37631387141063466 0.2572456271138725 0.4140039752128678 2.7834165454700512 0.11048787308893465 0.28728520014977516 2.0359143084253633e-07 6.691240505392841 0.5212822871650976 CWAGSLWLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CWAGSLWLFK 10 0 Q9BQA1;Q9BQA1-2 Q9BQA1 WDR77 Methylosome protein 50 0 8434420.0 1411900.0 4581100.0 2441420.0 False True 1851014.572859051 3897617.736987942 2188805.278154312 1.0 2.105665613949077 1.1824894899522669 20.819884822776164 -10.261163495406809 4.17204242352597 0.999472424550192 1.6440775519646529 0.39357254169317135 0.3768850745272872 53044579.88683555 65233260.40690172 212329.14734373288 0.1290177913291845 5.480705982777106e-11 10.261163495406809 0.6446051274144609 CWAGSLWLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 CWAGSLWLFK 10 0 Q9BQA1;Q9BQA1-2 Q9BQA1 WDR77 Methylosome protein 50 0 25918400.0 6328100.0 7342300.0 12248000.0 False True 9600190.346078984 6032009.199348268 9827177.431510897 1.0 0.628321833411556 1.023644019258912 23.194631580222737 -10.09303941882274 13.026335120353721 0.999999999956619 0.8259829263352341 0.20531290305641559 0.16138960655462065 0.0 0.0 0.1562648157735169 0.05208827153641775 8.071617647300484e-11 10.09303941882274 -0.17401707362138497 CWAGSLWLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CWAGSLWLFK 10 0 Q9BQA1;Q9BQA1-2 Q9BQA1 WDR77 Methylosome protein 50 0 12983500.0 1411900.0 5378000.0 6193600.0 False True 1933917.5851628368 5140382.177332246 4730799.241196019 1.0 2.658015117484659 2.4462258771992516 20.883094884299055 -10.21235999649364 7.937686789027045 0.9999991314157382 2.5521204973419556 0.9862280470308233 0.08646259528515794 1.3291598171789712e-06 1.3201395344053537e-07 0.08371709528532599 0.027905682634107372 6.13253454795929e-11 10.21235999649364 1.5521213659262174 CWAGSLWLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CWAGSLWLFK 10 0 Q9BQA1;Q9BQA1-2 Q9BQA1 WDR77 Methylosome protein 50 0 25478200.0 6328100.0 9667200.0 9482900.0 False True 8191850.195499684 9129211.821848242 7757109.502770758 1.0 1.1144261191279488 0.9469300973096705 22.965757902315186 -6.722767251559606 1.7492770740513635 1.0694054027460336 0.9471470430538971 0.5256952854463983 0.048134821594894225 0.34990993500722917 2.0939520191814465 0.021836260284956503 0.0546412483119196 1.8933580410849613e-07 6.722767251559606 -0.1222583596921365 CWFLAWNPAGTLLASCGGDRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CWFLAWNPAGTLLASCGGDRR 21 1 O76071 O76071 CIAO1 Probable cytosolic iron-sulfur protein assembly protein CIAO1 0 42625100.0 11553000.0 6860100.0 24212000.0 False True 17526745.63743469 5635861.556794054 19426487.587503392 1.0 0.32155778793050077 1.108391026455654 24.063054805854026 -6.6785706049432605 1.9068669796848035 0.570191864431096 1.1053696726576119 0.3176111699060321 0.28763036892671945 0.44172234711686065 3.1040840476823104 0.1210872828195519 0.3199571850753742 2.09618396780763e-07 6.6785706049432605 0.5351778082265158 CWFLAWNPAGTLLASCGGDRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CWFLAWNPAGTLLASCGGDRR 21 1 O76071 O76071 CIAO1 Probable cytosolic iron-sulfur protein assembly protein CIAO1 0 29847300.0 11553000.0 9718900.0 8575400.0 False True 14955586.243676271 9178034.671400286 7014765.191034431 1.0 0.6136860516103854 0.4690398006965799 23.834181127946476 -13.999999999999998 0.13635484543507811 2.840291704373895 0.2819202639696963 0.9996178579505097 0.0043812527086894764 11.93205167079082 0.11541292813330899 5.855761653961888 0.16690655191863052 1.0000000000000041e-14 13.999999999999998 -2.5583714404041986 CWIFSCLNVMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CWIFSCLNVMR 11 0 Q13867;K7ES02 Q13867 BLMH Bleomycin hydrolase 0 12522500.0 3170200.0 4682300.0 4670000.0 False True 4809425.172664714 3846706.982023121 3746972.453066288 1.0 0.799826765969167 0.7790894584165529 22.197433041260567 -13.999999999999998 0.3203541397320295 3.0567827548020907 0.7749887195681444 0.9996944832103435 0.0017410916769805287 18.040966024090288 0.18051899357747167 24.874402638509324 0.00689462756114479 1.0000000000000041e-14 13.999999999999998 -2.281794035233946 CWIFSCLNVMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CWIFSCLNVMR 11 0 Q13867;K7ES02 Q13867 BLMH Bleomycin hydrolase 0 9497700.0 3170200.0 2811300.0 3516200.0 False True 4103886.3939844635 2654848.6836686884 2876287.6792587196 1.0 0.6469108617529482 0.7008692256868572 21.968559363353016 -10.366160508688825 5.807729095935272 1.0000679510234651 0.6738900437199385 0.9798801979277234 0.022028409832247697 1.9385526221861558e-05 2.11565687318066e-06 0.021333342793771776 0.00710963870197691 4.3036752375115835e-11 10.366160508688825 -0.3261779073035266 CWYIHDLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CWYIHDLLK 9 0 Q9Y3C8 Q9Y3C8 UFC1 Ubiquitin-fold modifier-conjugating enzyme 1 0 6748900.0 2629000.0 2044800.0 2075100.0 False True 3446644.459272216 1739723.8105679739 1860388.5577647495 1.0 0.5047587098482822 0.539768049692478 21.716761053611005 -9.852878002308312 5.492670494234379 1.0000002390149103 0.5222633809215227 0.9959885033122919 0.014292503154629143 4.18268850696776e-08 8.747558402104549e-09 0.01383866347260105 0.004612885555911101 1.403207824406181e-10 9.852878002308312 -0.4777368580933876 CWYIHDLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CWYIHDLLK 9 0 Q9Y3C8 Q9Y3C8 UFC1 Ubiquitin-fold modifier-conjugating enzyme 1 0 10688500.0 2629000.0 3869200.0 4190300.0 False True 3601012.346053612 3698245.9502666197 3200637.441937431 1.0 1.0270017414185117 0.8888160145979628 21.779971115133897 -6.855998443836789 1.2057641284041645 1.014521330267673 0.882617405407663 0.9485899481525842 0.013559324012329815 0.1509824712236891 0.41940367390787614 0.008783913858221727 0.020420868902081973 1.3931617949112115e-07 6.855998443836789 -0.13190392486001 CYDFDVHTMK(ub)TLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CYDFDVHTMKTLK 13 1 Q5T8C6;Q13042-4;Q13042-3;Q13042-2;Q13042 Q5T8C6 CDC16 Cell division cycle protein 16 homolog 1 10801600.0 3445300.0 2467100.0 4889200.0 True False 4460008.767016167 2329803.716244802 3999415.7674283986 1.0 0.5223764880183153 0.8967282299994415 22.08861511537072 -9.855412003402652 6.448199526969035 1.0000000120930563 0.7095523590088432 0.44525461194153326 0.15282845869609274 2.6624545306369596e-08 4.787398659092011e-09 0.14797552545408835 0.04932517294635729 1.3950442923961954e-10 9.855412003402652 -0.29044765308421316 CYFCSGPIYPGHGMMFVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CYFCSGPIYPGHGMMFVR 18 0 Q9UHA3;H3BPF2 Q9UHA3 RSL24D1 Probable ribosome biogenesis protein RLP24 0 5593300.0 1592100.0 2531400.0 1469800.0 False True 2087258.5179183339 2153724.987319914 1317719.1953171538 1.0 1.0318439085676214 0.6313157589273333 20.99317786623837 -6.887667384094415 1.0361245294572243 1.022739796611407 0.5984059506481927 0.9793612319955718 0.026113523417268907 0.12105442793691232 0.23308757630734886 0.019260367552051558 0.047628545231281676 1.2951874151984505e-07 6.887667384094415 -0.4243338459632142 CYFCSGPIYPGHGMMFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CYFCSGPIYPGHGMMFVR 18 0 Q9UHA3;H3BPF2 Q9UHA3 RSL24D1 Probable ribosome biogenesis protein RLP24 0 7043600.0 1592100.0 2645000.0 2806500.0 False True 2180742.394884732 2528135.1541546625 2143662.5016818405 1.0 1.1593002273376232 0.9829966651311645 21.05638792776126 -6.668724761739263 1.9419380024564674 1.101792322991629 0.983713871984323 0.27339008175012613 0.06768728045458412 0.4640525445264755 3.3726157925990425 0.028073198078797473 0.07512827827307171 2.1442491088688194e-07 6.668724761739263 -0.11807845100730607 CYFFLSAFVDTAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 CYFFLSAFVDTAQR 14 0 Q13867;K7ES02;K7EMJ3 Q13867 BLMH Bleomycin hydrolase 0 30885200.0 8460100.0 9703100.0 12722000.0 False True 12834590.216156937 7971505.994333683 10207491.123749321 1.0 0.6210954818252539 0.795311026829632 23.61353389837528 -10.10737283551058 4.990608271197683 1.0000102406595621 0.7082032543263981 0.7890503140956429 0.07112319842388953 8.104198277429776e-06 1.4495110572282636e-06 0.06886715645284483 0.022954913584876075 7.809570764068475e-11 10.10737283551058 -0.29180698633316404 CYFFLSAFVDTAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CYFFLSAFVDTAQR 14 0 Q13867;K7ES02;K7EMJ3 Q13867 BLMH Bleomycin hydrolase 0 20578400.0 8460100.0 3939400.0 8178900.0 False True 10951766.223502597 3720168.926989094 6690424.122600863 1.0 0.3396866634174107 0.6108990993839101 23.38466022046773 -10.379453141301749 5.919961067088004 1.0001112509459562 0.4752928814007765 0.8330720323927544 0.11072201333586505 0.00016261069010142635 1.7045453780782607e-05 0.10722860765305285 0.035735376142363114 4.173946313054425e-11 10.379453141301749 -0.5248183695451797 CYGFVTMSTAEEATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CYGFVTMSTAEEATK 15 0 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 0 13769500.0 3726600.0 4429800.0 5613100.0 False True 4885608.688445735 3768891.1072251606 5032310.256657186 1.0 0.7714271337650177 1.0300272857624464 22.22010688527346 -6.673390851532125 1.9252013169087137 0.8545307704213212 1.0290021664924425 0.29419493200089886 0.09701752046841407 0.4533931499596433 3.242869375973123 0.04052173388545982 0.10779344906172586 2.1213344675897317e-07 6.673390851532125 0.17447139607112128 CYGFVTMSTAEEATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CYGFVTMSTAEEATK 15 0 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 0 13863800.0 3726600.0 3369100.0 6768100.0 False True 5104424.727578314 3220242.0218761736 5169614.173394921 1.0 0.6308726631774525 1.0127711640969843 22.28331694679635 -10.97071521556336 11.515259996230325 1.081965743671225 0.8218219136372189 0.22494804592626017 0.15590941013111087 0.08415378591238952 0.00021401371705388156 0.0387214393693217 0.050319545746234526 1.0697561315898303e-11 10.97071521556336 -0.2601438300340062 CYGFVTMSTSDEATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CYGFVTMSTSDEATK 15 0 Q14151 Q14151 SAFB2 Scaffold attachment factor B2 0 5529900.0 1510000.0 2193300.0 1826600.0 False True 1979624.6228607995 1866068.1894164397 1637600.9539844317 1.0 0.9426373908805716 0.8272280184199255 20.9167954612054 -6.959928356653319 0.43644221335341804 1.0042830064153956 0.7611092338425197 0.9997675269499589 0.001095464706239243 0.07972671299160253 0.021225941246375588 0.0015151536996108358 0.00956908790046472 1.0966590914817252e-07 6.959928356653319 -0.24317377257287587 CYGFVTMSTSDEATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CYGFVTMSTSDEATK 15 0 Q14151 Q14151 SAFB2 Scaffold attachment factor B2 0 5106500.0 1510000.0 1691400.0 1905100.0 False True 2068287.8062156523 1616668.355288167 1455154.6167661021 1.0 0.781645741192173 0.7035551882059391 20.98000552272829 -13.999999998341552 0.14317704626835434 2.046338314197383 0.6105155285841383 0.9995905752959393 0.002538531193682595 11.93861030621368 0.11877440229863616 3.484336383325574 0.08336671413346455 1.0000000038187168e-14 13.999999998341552 -1.435822785613245 CYK(ub)LTDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 CYKLTDK 7 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 7601600.0 1489800.0 1728700.0 4383100.0 True False 1928575.4683483855 1632496.3253505714 3585420.774403876 1.0 0.8464778029913584 1.8591031739475552 20.879104171438968 -6.868255680897241 1.1432123521781739 0.9140164655246623 1.9164919441601482 0.9629148025880939 0.08581157464150806 0.1385421296044604 0.33948839802074227 0.058311024965666564 0.1376580399783867 1.3543918105312196e-07 6.868255680897241 1.002475478635486 CYLFGGLANDSEDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CYLFGGLANDSEDPK 15 0 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 6188400.0 1625500.0 2045900.0 2517000.0 False True 2131046.2413643934 1740659.694855739 2256564.984768867 1.0 0.8168099129286321 1.0589000562109392 21.023130467683316 -6.704320122814523 1.815330386163345 0.8867320127262114 1.058244442734504 0.4381558309572673 0.07726737604048613 0.3866065556751978 2.4797482098602 0.03391771865309699 0.08676957067360767 1.9755129329223068e-07 6.704320122814523 0.17151243000829253 CYLFGGLANDSEDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CYLFGGLANDSEDPK 15 0 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 1625500.0 1625500.0 0.0 0.0 False True 2226491.277485793 0.0 0.0 1.0 0.0 0.0 21.086340529206208 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 CYTAVVPLVYGGETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 CYTAVVPLVYGGETK 15 0 D6RD17;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 0 31426800.0 4779800.0 13256000.0 13391000.0 False True 6266364.087649041 11278256.471483294 12005427.775542274 1.0 1.7998086791210643 1.9158522562078522 22.57919716478895 -11.084539376303878 0.3512430782299417 4.908100868812148e-13 1.9349530301751725 0.999399333587744 0.00997865045975833 2.9923126733992254 0.17624987557157565 2.422741626112659 0.03438665833134833 8.231152039128953e-12 11.084539376303878 1.9349530301746818 CYTAVVPLVYGGETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CYTAVVPLVYGGETK 15 0 D6RD17;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 0 35126800.0 4779800.0 12735000.0 17612000.0 False True 6547021.229238131 12172325.59098662 13452408.330525745 1.0 1.859215842561595 2.054737239960223 22.642407226311843 -10.83330862955195 0.29006290278014696 3.5785255015721803e-25 2.120273366684637 0.9991862957741652 0.013068397904515316 2.6063235897465007 0.1470072129701937 1.8634539088806727 0.07336835846856211 1.4678827621748158e-11 10.83330862955195 2.120273366684637 CYVPQNLGEALDFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 CYVPQNLGEALDFR 14 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 18086100.0 2241500.0 7760800.0 8083800.0 False True 2938628.2067168755 6602918.891361463 7247365.921285093 1.0 2.246939193011573 2.466241188565351 21.486711411043647 -10.510932699670375 0.3592689446562716 8.150637090488329e-25 2.502431648983576 0.9991716482204754 0.018585089020647236 2.015742020963486 0.17123463880493325 1.9033231815319176 0.06310197287223535 3.083665772677181e-11 10.510932699670375 2.502431648983576 CYVPQNLGEALDFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 CYVPQNLGEALDFR 14 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 9455800.0 4431900.0 1861100.0 3162800.0 False True 4291211.7603994105 2604246.9355082884 2334367.7980338363 1.0 0.6068791476433442 0.5439880221190859 22.032953665502525 -13.999999999999998 0.25794282189490525 3.8472312454530733 0.5205447434245014 0.9995581643649094 0.004241444977101622 14.32719645916717 0.1607135825352784 21.237058282639328 0.027796457392249656 1.0000000000000041e-14 13.999999999999998 -3.326686502028572 CYVPQNLGEALDFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 CYVPQNLGEALDFR 14 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 19926200.0 2241500.0 9408900.0 8275800.0 False True 3070243.1242598575 8993183.686928477 6321226.485451116 1.0 2.929143824431318 2.0588683793486133 21.54992147256654 -10.564380471415298 7.318656894170347 0.9990312705480057 2.4940061018899655 0.7971369608107222 0.35528846268769176 0.005618006712443816 0.00033439356784234817 0.3441376025767642 0.1146688582574221 2.726588060152956e-11 10.564380471415298 1.4949748313419597 DAAIYLVTSLASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DAAIYLVTSLASK 13 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 15702000.0 3729600.0 6535000.0 5437400.0 False True 5658075.870282728 5368778.191811955 4362695.506702917 1.0 0.9488699541852701 0.7710563814841382 22.431880091577387 -6.9480911972024755 0.5794239477313722 1.0021300966931708 0.7090100464040617 0.9990428202571552 0.0030356507015460513 0.08426147193381305 0.03920571881876332 0.0031825538522647526 0.014851451771292044 1.1269607815998102e-07 6.9480911972024755 -0.29312005028910904 DAAIYLVTSLASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAAIYLVTSLASK 13 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 5129800.0 2113700.0 1180900.0 1835200.0 False True 1757635.2027868638 1174538.257309702 2218931.8349939245 1.0 0.6682491653827726 1.262453000187775 20.745204239496953 -6.755183259289572 1.6304774220192635 0.806146768481577 1.2641294616874597 0.671002667989236 0.13945633764206017 0.29110861830551826 1.5240678062693866 0.06752050397817494 0.16305151017207578 1.75718197922574e-07 6.755183259289572 0.4579826932058827 DAAIYLVTSLASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DAAIYLVTSLASK 13 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 12851800.0 3729600.0 6201100.0 2921100.0 False True 4828040.721406991 5856003.333795001 2389489.773017078 1.0 1.2129150667329998 0.4949191423391167 22.203006413669836 -6.827254522984029 1.3400859292650447 1.114001852551852 0.47665307329190076 0.9002823336299404 0.09508206515791198 0.18422179922592818 0.6479709752531365 0.0557234573505124 0.12826199460263865 1.488488477246706e-07 6.827254522984029 -0.6373487792599513 down DADSQNPDAPEGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DADSQNPDAPEGKR 14 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 30829700.0 7301300.0 10437900.0 13090500.0 True False 9572075.005889785 8880606.00661553 11736020.632942729 1.0 0.9277618490401729 1.2260686032779151 23.190400271069084 -6.842752110016578 1.2697472464341375 0.9615762991893755 1.23641457740532 0.9290503354735382 0.03384582279292417 0.1656128821598908 0.5175071913210629 0.02089248209157138 0.048168338660377195 1.4363090270660803e-07 6.842752110016578 0.2748382782159444 DADSQNPDAPEGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DADSQNPDAPEGKR 14 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 28445500.0 8217800.0 7270100.0 12957600.0 True False 7956930.437196302 10173088.843070649 9563615.84033238 1.0 1.2785192635987441 1.2019227660487388 22.923780555732552 -10.086110902371464 4.451712862648993 0.9999800030325974 1.2402210147825856 0.9291495324010248 0.03127038923245959 3537899.053198977 8034299.248921347 397.2879110430547 0.010704685844083418 8.201420843431221e-11 10.086110902371464 0.24024101174998824 DADSQNPDAPEGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DADSQNPDAPEGKR 14 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 34664500.0 3306000.0 10911400.0 20447100.0 True False 5015443.700974558 8964175.41884268 16405721.722717723 1.0 1.787314533527879 3.2710409488855205 22.257945906628198 -6.961190939997086 0.4183111965625707 0.9332120508780463 4.180958607307238 0.9998118500321066 0.012915262760838545 0.0792784084333183 0.019579459366165997 0.01917362357098374 0.12356744825970971 1.0934755079531813e-07 6.961190939997086 3.2477465564291914 DADSQNPDAPEGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DADSQNPDAPEGKR 14 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 30817300.0 7301300.0 9330500.0 14185500.0 True False 10000787.920213483 8918247.65816261 10835177.05954309 1.0 0.8917545026764487 1.083432340130236 23.253610332591975 -6.753515796855445 1.6370431095842746 0.9366191338997871 1.083912635087505 0.6638561296423484 0.045495503459648236 0.2939622726095667 1.5510319258483112 0.021945252996108864 0.053077602186088084 1.763941602396434e-07 6.753515796855445 0.1472935011877179 DADSQNPDAPEGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DADSQNPDAPEGKR 14 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 31218200.0 8217800.0 13493800.0 9506600.0 True False 6833464.810267255 13421106.221090421 11494386.106447933 1.0 1.9640265361321918 1.6820729199011404 22.70418583116683 -10.021478909181015 4.914002439765198 0.9999875376256123 1.8230497280275513 0.9191036473746 0.1151070818557457 15410151.05577565 31427031.289767332 1324.7115094287644 0.03940421656581032 9.517460670207456e-11 10.021478909181015 0.823062190401939 DADSQNPDAPEGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DADSQNPDAPEGKR 14 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 23038800.0 3306000.0 7804400.0 11928400.0 True False 4279682.17100266 7370078.279381031 9757553.595719732 1.0 1.7221087886660382 2.2799715506522524 22.029072228720647 -6.974004461900121 0.13096521749405302 0.1480986743794327 3.868430628180975 0.9999991951428484 0.000470045533026248 0.07502319094454765 0.00393492686877139 0.03472952609484977 0.07584595016400536 1.0616846494957774e-07 6.974004461900121 3.720331953801542 DADVQNFVSFISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DADVQNFVSFISK 13 0 P42126-2;P42126;Q96DC0;H3BS70 P42126-2 ECI1;DCI Enoyl-CoA delta isomerase 1, mitochondrial 0 9183300.0 2115300.0 3822000.0 3246000.0 False True 2773178.7845943393 3251772.498039317 2910135.0578306443 1.0 1.172579465883584 1.0493860237201904 21.40310919808279 -10.777701385616776 6.674729420477627 0.9963568893673702 1.1109827448018872 0.5197197390138306 0.05029351215956421 0.002807439488418962 9.350032132491208e-05 0.05014044556241398 0.016232161251356028 1.6683939809765478e-11 10.777701385616776 0.11462585543451698 DADVQNFVSFISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DADVQNFVSFISK 13 0 P42126-2;P42126;Q96DC0;H3BS70 P42126-2 ECI1;DCI Enoyl-CoA delta isomerase 1, mitochondrial 0 10044100.0 3135100.0 1938100.0 4970900.0 False True 3035577.966566975 2711993.437057982 3668872.1661965325 1.0 0.8934026623355208 1.2086239281627704 21.533539797540023 -6.815485058921093 1.3914032068749815 0.9422702966326155 1.2148556631717706 0.8736597687899885 0.04653332740349999 0.19941285392994595 0.7597924710947719 0.026289268055064076 0.060674326268040944 1.5293783608789217e-07 6.815485058921093 0.2725853665391551 DAEAEGLSGTTLLPK(ub)LIPSGAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAEAEGLSGTTLLPKLIPSGAGR 23 1 Q9UI14;M0R3D4 Q9UI14 RABAC1 Prenylated Rab acceptor protein 1 1 27700500.0 7259300.0 7271200.0 13170000.0 True False 7028857.495039924 10174628.078807088 9720381.908468962 1.0 1.447550769949035 1.3829248800858993 22.74485877495298 -10.6100497818429 6.32281902678558 0.9985786188034084 1.4152378250172584 0.9821572589722525 0.026383409056331266 0.000530216741401258 3.270032600220391e-05 0.02562207322811039 0.008515208657612388 2.4544275560655483e-11 10.6100497818429 0.41665920621385 DAEALTK(ub)NDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAEALTKNDR 10 1 Q10570;E9PIM1 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 1 6032900.0 1526300.0 1848800.0 2657800.0 True False 2000994.0807102246 1572966.2465659555 2382796.3514178363 1.0 0.7860924036355237 1.190806296924225 20.93228546883038 -6.763107327487509 1.6006923520697747 0.8762282014061398 1.192519188988577 0.703505949246725 0.09001526971840228 0.27775350141423966 1.403264149355022 0.04435469180806859 0.10627032967886713 1.7254114372080002e-07 6.763107327487509 0.3162909875824371 DAEALTK(ub)NDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAEALTKNDR 10 1 Q10570;E9PIM1 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 1 6823900.0 1795500.0 1646800.0 3381600.0 True False 1738502.8353070111 2304375.8279485493 2495857.514174537 1.0 1.325494431846358 1.4356361482342825 20.72941398926865 -12.576899048117687 0.17005740814493756 3.79524323717972e-08 1.5399585329804024 0.9995008793498306 0.004131953058294591 6.915047939467435 0.11844209152565953 2.443280873638776 0.08913388355065807 2.649115854815616e-13 12.576899048117687 1.53995849502797 DAEALTK(ub)NDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DAEALTKNDR 10 1 Q10570;E9PIM1 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 1 19015700.0 2366500.0 2394200.0 14255000.0 True False 3590153.5143243456 1966936.3040300196 11437493.001811536 1.0 0.5478696930875364 3.185794968426032 21.775614104074247 -6.862752570753402 1.171853028280609 0.7526913033269692 3.3203536759845322 0.9568933403601352 0.23914820146802 0.14398721769786152 0.3741872883325846 0.1589916756438591 0.3723344186205645 1.3716630169052575e-07 6.862752570753402 2.567662372657563 up DAEALTK(ub)NDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAEALTKNDR 10 1 Q10570;E9PIM1 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 1 6511000.0 1526300.0 1552000.0 3432700.0 True False 2090614.3567065902 1483427.508222321 2621966.9586756644 1.0 0.7095653502347561 1.2541609839540806 20.99549553035327 -6.761823974067335 1.6054816634590043 0.8316799134282309 1.2563396141889582 0.6983875794804726 0.12219235177837381 0.2798785169011898 1.4221991065713746 0.06003758268667731 0.14402818135398054 1.730517621300271e-07 6.761823974067335 0.42465970076072734 DAEDAMDAMDGAVLDGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAEDAMDAMDGAVLDGR 17 0 J3QL05;J3KP15;Q01130-2;Q01130 J3QL05 SRSF2 Serine/arginine-rich splicing factor 2 0 10676100.0 3201300.0 1120800.0 6354000.0 False True 3099676.4838030245 1568341.2848947863 4689696.784085933 1.0 0.5059693465075983 1.5129633071681392 21.56368621722079 -6.773298343710325 1.5617751220797058 0.7178334219653503 1.5193544560242687 0.7430352321371628 0.20840763055316053 0.2611290179179498 1.2574247994839967 0.10515369773514667 0.24956527435125253 1.6853948257853642e-07 6.773298343710325 0.8015210340589184 DAEDAVYGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAEDAVYGR 9 0 J3KTL2;Q07955;Q07955-3;Q07955-2 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 3558100.0 2280200.0 1277900.0 0.0 False True 2207816.299118377 1788172.1341604628 0.0 1.0 0.8099279522823135 0.0 21.074188707302454 -7.235444560051096 0.8640437967465506 0.9895739576203926 2.5518626494188777e-16 0.9889810305146282 0.04551595026320223 0.09676127827575948 0.13866292373984018 0.03850632386625281 0.06773017980226098 5.815076600471557e-08 7.235444560051096 -0.9895739576203924 down DAENHEAQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAENHEAQLK 10 0 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 0 3543860.0 1203400.0 552160.0 1788300.0 False True 1165198.7257078553 772640.3674763616 1319890.5821499662 1.0 0.663097504682718 1.1327600631798975 20.15214459814648 -6.714154151418251 1.7802379854996813 0.7937677672917869 1.1318056335347135 0.48489130413478554 0.14188008371443903 0.3667802167690024 2.268360138139155 0.06336034501463167 0.16016899517999886 1.9312826928140065e-07 6.714154151418251 0.33803786624292664 DAFALAK(ub)EK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAFALAKEK 9 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 133159000.0 48985000.0 42281000.0 41893000.0 True False 64219809.37141484 35972839.61004719 37558314.22603179 1.0 0.5601517656646801 0.5848400142207449 25.936515046819245 -10.539976053621762 6.269550270082083 1.0005582092607 0.5724958899427129 0.9975049661283379 0.010078935267560422 7.87387125187039e-05 5.777389008579672e-06 0.009770992631658764 0.0032529623698970096 2.8841905288939806e-11 10.539976053621762 -0.428062319317987 DAFALAK(ub)EK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAFALAKEK 9 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 157677000.0 58636000.0 57623000.0 41418000.0 True False 56774632.27572367 80632164.39997528 30569383.286633827 1.0 1.4202146481264464 0.5384338402787863 25.758743120965665 -6.777122547098814 1.5471484773777529 1.238824914524876 0.5320767271708491 0.7570577583181726 0.17749889668395138 0.25506897522412764 1.2057516327518656 0.09038135878374325 0.21377484527087748 1.670619140633407e-07 6.777122547098814 -0.7067481873540269 DAFALAK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DAFALAKEK 9 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 262037000.0 138430000.0 66588000.0 57019000.0 True False 210008430.58859906 54704851.14558136 45749169.65768456 1.0 0.26048883367328574 0.21784444333716282 27.64587200377234 -13.585937079293231 0.40984612329707604 9.9990396218923 0.21586060840509239 0.9998440069416549 0.004484836350969025 19.85240444077556 0.21169622309796082 157.40030843759368 0.010627849458579726 2.5945552347825328e-14 13.585937079293231 -9.783179013487207 DAFALAK(ub)EK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAFALAKEK 9 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 113496000.0 48985000.0 35740000.0 28771000.0 True False 67096078.26985025 34160888.62362481 21975882.357344806 1.0 0.5091339092313995 0.32752856685544485 25.999725108342137 -13.999999999999998 0.13814351774415376 3.3412240045831463 0.09767518654256237 0.9996104380565053 0.005606338347367686 11.932560406884894 0.11631035922466054 7.539023663496593 0.20524028418309326 1.0000000000000041e-14 13.999999999999998 -3.243548818040584 DAFALAK(ub)EK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAFALAKEK 9 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 139721000.0 58636000.0 56970000.0 24115000.0 True False 48758432.01523892 56663091.30234036 29157335.00483787 1.0 1.1621188163850495 0.5979957476016674 25.53914839639994 -6.829887460061883 1.3286534293264058 1.0866288333194403 0.582876099843818 0.9056027060402898 0.07285968865154253 0.18095268514066054 0.6248187312128467 0.04305925863926469 0.0990795512269181 1.4794917233076913e-07 6.829887460061883 -0.5037527334756222 DAFALAK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DAFALAKEK 9 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 248081000.0 138430000.0 62553000.0 47098000.0 True False 179200363.86324823 59071870.56149382 38526647.266289495 1.0 0.32964146549709505 0.2149920147243118 27.41699832586479 -13.999999999999252 0.24844552696485095 5.625755139464523 0.16820680425330878 0.999539791917938 0.007427089803156644 13.936904556426382 0.15772742187789682 32.144233704528794 0.053371270984271 1.000000000001722e-14 13.999999999999252 -5.457548335211214 DAFDTLFDHAPDK(ub)LSVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAFDTLFDHAPDKLSVVK 18 1 Q9HBI1-3;Q9HBI1;Q9HBI1-2;A0A087WZB5 Q9HBI1-3 PARVB Beta-parvin 1 16071600.0 3775400.0 7495800.0 4800400.0 True False 4949585.96102561 6377455.858399546 4303700.656688308 1.0 1.2884826950410344 0.8695072053656249 22.238876416343054 -6.721375646184369 1.7539407922459642 1.175241350069019 0.8700883759745675 0.5192584823690446 0.1213737248513376 0.35261826910133337 2.120624212609434 0.05492576106221331 0.13768371395145318 1.8994346393208504e-07 6.721375646184369 -0.30515297409445163 DAFDTLFDHAPDK(ub)LSVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAFDTLFDHAPDKLSVVK 18 1 Q9HBI1-3;Q9HBI1;Q9HBI1-2;A0A087WZB5 Q9HBI1-3 PARVB Beta-parvin 1 74005000.0 16884000.0 32106000.0 25015000.0 True False 16348026.661834352 44926093.23057819 18462821.066085868 1.0 2.7481049645864233 1.1293608365093175 23.96261316556168 -6.627971137169178 2.087716122657565 2.1533968459669492 1.1358258005904118 0.11018306753441764 0.7502349558869686 0.5643897020093372 4.6850408573996 0.2941774505099268 0.8312489321226287 2.3552058036094008e-07 6.627971137169178 -1.0175710453765374 DAFDTLFDHAPDK(ub)LSVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAFDTLFDHAPDKLSVVK 18 1 Q9HBI1-3;Q9HBI1;Q9HBI1-2;A0A087WZB5 Q9HBI1-3 PARVB Beta-parvin 1 28955900.0 3775400.0 8970500.0 16210000.0 True False 5171267.4063487295 8574153.648523394 12381531.855429398 1.0 1.6580371840754096 2.394293484074847 22.302086477865945 -6.969671432513212 0.26591631449175196 0.8076699344235522 3.2666748979151996 0.9999797055076296 0.0025656313178549035 0.07640945517695913 0.009410943677376106 0.014801875136122128 0.06886863281344045 1.0723302748265914e-07 6.969671432513212 2.4590049634916475 DAFDTLFDHAPDK(ub)LSVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAFDTLFDHAPDKLSVVK 18 1 Q9HBI1-3;Q9HBI1;Q9HBI1-2;A0A087WZB5 Q9HBI1-3 PARVB Beta-parvin 1 58655000.0 16884000.0 28482000.0 13289000.0 True False 14039794.08802262 28328561.812765624 16067668.45860629 1.0 2.017733425088676 1.1444376148161357 23.743018440995957 -10.383426788249366 5.707696779329365 0.9998241966613762 1.5810855199524074 0.3712003523562778 0.35652152161302453 0.0007978194266947866 8.61848183799864e-05 0.3453030529137208 0.1150668263143134 4.1359303044804003e-11 10.383426788249366 0.5812613232910312 DAFK(ub)SNDSQQQDVSEFTHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAFKSNDSQQQDVSEFTHK 19 1 Q9UHP3;Q9UHP3-1;Q9UHP3-3 Q9UHP3 USP25 Ubiquitin carboxyl-terminal hydrolase 25 1 13885600.0 5975400.0 5404400.0 2505800.0 True False 7833807.26585592 4598084.586186208 2246523.8533308785 1.0 0.5869540097351147 0.28677292880595573 22.901282203610492 -8.023563927566123 0.23962640841368363 1.1928445930333287 6.04642198012e-10 0.9996603541747587 0.005388527876007325 0.09883864343203629 0.04427668861429559 0.072257123408417 0.0983047739512058 9.471877494739412e-09 8.023563927566123 -1.1928445924286866 down DAFK(ub)SNDSQQQDVSEFTHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAFKSNDSQQQDVSEFTHK 19 1 Q9UHP3;Q9UHP3-1;Q9UHP3-3 Q9UHP3 USP25 Ubiquitin carboxyl-terminal hydrolase 25 1 13725400.0 4948500.0 3675900.0 5101000.0 True False 4791412.576171953 5143706.039565261 3764895.073280196 1.0 1.0735260130061204 0.7857588995786536 22.19201961489008 -6.8389579641186256 1.2874408682556129 1.0391189766836815 0.7765002741688475 0.9226100640284345 0.03395940254917675 0.17002287551090858 0.5479102683691116 0.020688102012694092 0.04764322581017488 1.4489120886886984e-07 6.8389579641186256 -0.262618702514834 DAFK(ub)SNDSQQQDVSEFTHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DAFKSNDSQQQDVSEFTHK 19 1 Q9UHP3;Q9UHP3-1;Q9UHP3-3 Q9UHP3 USP25 Ubiquitin carboxyl-terminal hydrolase 25 1 33421000.0 14583000.0 11173000.0 7665000.0 True False 22123477.160106484 9179090.854952546 6150009.390311151 1.0 0.4149027202425699 0.27798565956896576 24.399074816845623 -13.999999999999979 0.20404292148194736 4.303722841981478 0.19252559303736705 0.9994875480832605 0.0070881909046811775 12.613769320042397 0.14321082676932376 16.66028322196767 0.0846250153719093 1.000000000000049e-14 13.999999999999979 -4.11119724894411 DAFK(ub)SNDSQQQDVSEFTHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAFKSNDSQQQDVSEFTHK 19 1 Q9UHP3;Q9UHP3-1;Q9UHP3-3 Q9UHP3 USP25 Ubiquitin carboxyl-terminal hydrolase 25 1 13687300.0 5975400.0 3872400.0 3839500.0 True False 8184666.859113263 3701304.563685641 2932689.176984653 1.0 0.45222421723425466 0.35831503315486 22.964492265133384 -13.999999999999998 0.24810520542801337 4.7734464939815044 0.3198691732068495 0.9995391639409025 0.006074492584137237 13.923646451913937 0.15761985423623726 26.15545164587413 0.04379984987542983 1.0000000000000041e-14 13.999999999999998 -4.453577320774655 DAFK(ub)SNDSQQQDVSEFTHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAFKSNDSQQQDVSEFTHK 19 1 Q9UHP3;Q9UHP3-1;Q9UHP3-3 Q9UHP3 USP25 Ubiquitin carboxyl-terminal hydrolase 25 1 14641200.0 4948500.0 6034500.0 3658200.0 True False 4114897.0057202033 6001990.950745526 4423112.706394272 1.0 1.4586005293454574 1.0749024095246156 21.972424890324355 -10.2065292815143 5.914183505329275 0.9999945877807196 1.2667514694350392 0.39188506051558036 0.15664410147106683 1.11788181282946e-05 1.499969018622654e-06 0.15167307649745215 0.05055666635658749 6.215423399797347e-11 10.2065292815143 0.26675688165431966 DAFK(ub)SNDSQQQDVSEFTHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DAFKSNDSQQQDVSEFTHK 19 1 Q9UHP3;Q9UHP3-1;Q9UHP3-3 Q9UHP3 USP25 Ubiquitin carboxyl-terminal hydrolase 25 1 36846000.0 14583000.0 11693000.0 10570000.0 True False 18877980.97390558 11042274.271026913 8646368.457358709 1.0 0.5849287742312216 0.4580134109315135 24.170201138938072 -13.999999999999998 0.16597859513507396 3.072100879321482 0.34112844447117174 0.9995219328702025 0.005060692853442176 12.054875024457855 0.12892236295687945 8.04038733024782 0.10738710756922883 1.0000000000000041e-14 13.999999999999998 -2.7309724348503104 DAFLK(ub)RPISNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAFLKRPISNK 11 2 Q9NWK9-2;Q9NWK9 Q9NWK9-2 ZNHIT6 Box C/D snoRNA protein 1 1 3966140.0 702780.0 945360.0 2318000.0 True False 680470.6335823232 1322847.1779872717 1710846.2614905897 1.0 1.9440180262051439 2.5142102789710057 19.376173376505054 -8.787785889161738 0.16773726105548276 1.9095604425731997e-20 3.3577006572437447 0.99979630539794 0.008911845494318288 0.3205271463344375 0.049985475256284655 0.5257344485820646 0.3617065733157542 1.630099487348403e-09 8.787785889161738 3.3577006572437447 DAFLK(ub)RPISNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DAFLKRPISNK 11 2 Q9NWK9-2;Q9NWK9 Q9NWK9-2 ZNHIT6 Box C/D snoRNA protein 1 1 16159500.0 1804900.0 2508600.0 11846000.0 True False 2336478.6298979754 2368994.2047633724 9690149.550224343 1.0 1.0139164871654816 4.147330699381348 21.155904411285626 -6.90787499699929 0.9100916067508331 0.8963435522787843 4.534382232928481 0.9900944681109356 0.1473387566823387 0.10583982162834606 0.14651662387099296 0.11937489417679766 0.324870122766335 1.236303227452797e-07 6.90787499699929 3.6380386806496965 up DAFPVAGQK(ub)LIYAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAFPVAGQKLIYAGK 15 1 P54727;Q5W0S5;Q5W0S4;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 1 67098000.0 16111000.0 22333000.0 28654000.0 True False 21121677.01914596 19001003.453352153 25689158.948576506 1.0 0.8995972922097283 1.216246178051596 24.33222105057239 -6.821440329010947 1.365691933499176 0.9459614224302755 1.2233714377055194 0.8876517140592357 0.044285685405848894 0.1916162371216651 0.7018582550020621 0.02548002078151452 0.05870421603036713 1.5085498673273357e-07 6.821440329010947 0.2774100152752439 DAFPVAGQK(ub)LIYAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAFPVAGQKLIYAGK 15 1 P54727;Q5W0S5;Q5W0S4;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 1 156390000.0 56747000.0 29640000.0 70003000.0 True False 54945597.54673741 41475406.57055809 51667114.255015455 1.0 0.7548449452256588 0.940332193331172 25.711500555723948 -10.515356142638 5.131233350334642 1.0004968174209283 0.8475885692784132 0.47374344635580656 0.07572485194192993 0.0004317747659406404 4.078093074321662e-05 0.07355676147482315 0.024440090872091966 3.052416955944526e-11 10.515356142638 -0.15290824814251514 DAFPVAGQK(ub)LIYAGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DAFPVAGQKLIYAGK 15 1 P54727;Q5W0S5;Q5W0S4;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 1 234729000.0 119860000.0 90074000.0 24795000.0 True False 181836382.93974888 73999590.94862579 19894257.381965455 1.0 0.406957011310247 0.10940746323884686 27.438065650793675 -8.818064280940757 0.3228456526637505 1.1965355618616955 3.211404186556661e-18 0.9983172261110411 0.015185949320758068 0.34553715072569163 0.10636604199226356 0.17303431111503487 0.0896639527531023 1.5203224865956885e-09 8.818064280940757 -1.1965355618616955 DAFPVAGQK(ub)LIYAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAFPVAGQKLIYAGK 15 1 P54727;Q5W0S5;Q5W0S4;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 1 87935000.0 16111000.0 38509000.0 33315000.0 True False 22067672.08340426 36807545.04776633 25446683.143962413 1.0 1.6679396407855371 1.1531204128730597 24.39543111209528 -10.213633990045956 3.5392049488399793 0.9993270590476234 1.4105300267471217 0.4588305481666163 0.21017407216031841 174883935.56863943 293635962.2205663 1323623.5866887663 0.07691585537564222 6.114571249688133e-11 10.213633990045956 0.41120296769949827 DAFPVAGQK(ub)LIYAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAFPVAGQKLIYAGK 15 1 P54727;Q5W0S5;Q5W0S4;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 1 121296000.0 56747000.0 35540000.0 29009000.0 True False 47187644.81834992 35348538.96586231 35074647.77753859 1.0 0.7491058115304852 0.7433015127701196 25.491905831158224 DAFPVAGQK(ub)LIYAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DAFPVAGQKLIYAGK 15 1 P54727;Q5W0S5;Q5W0S4;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 1 250884000.0 119860000.0 85154000.0 45870000.0 True False 155161132.79382282 80415105.04361802 37522130.66594548 1.0 0.5182683549395912 0.24182686727226113 27.209191972886124 -8.784595780601704 0.22503764719902425 1.3165391409189535 2.798182273167379e-13 0.9994577170729461 0.007295391193576519 0.31460921571472034 0.06772088117101942 0.19770871017291683 0.12298058370444828 1.642117462248094e-09 8.784595780601704 -1.3165391409186737 down DAGDK(ub)DKEQELSEEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAGDKDKEQELSEEDK 16 2 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 33598100.0 16949100.0 10800000.0 5849000.0 True False 22220434.235317867 9188682.098070266 5243801.58756976 1.0 0.41352396630779975 0.2359900590617214 24.405383674593732 -13.999999999999998 0.16742127375381444 3.93818321311331 0.07500692722220177 0.9995188375019411 0.007161027897956115 12.067473212513136 0.12951665408129925 11.512854478186236 0.14821145938056504 1.0000000000000041e-14 13.999999999999998 -3.8631762858911083 DAGDK(ub)DKEQELSEEDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAGDKDKEQELSEEDK 16 2 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 34220600.0 12715700.0 16001700.0 5503200.0 True False 12312047.06372228 22391262.25776314 4061746.827538832 1.0 1.8186465777684924 0.32990020315198915 23.553567315810714 -6.7574123541749875 1.622217134334172 1.4770408777734398 0.3251452245272291 0.6803205659363059 0.34420873478245173 0.2872822459068725 1.4894088266289873 0.16746428763679444 0.4034770467745886 1.7481860316877112e-07 6.7574123541749875 -1.1518956532462108 DAGDK(ub)DKEQELSEEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAGDKDKEQELSEEDK 16 2 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 39222200.0 16949100.0 15928400.0 6344700.0 True False 23215640.302205108 15224630.61982499 4846212.533198204 1.0 0.6557919756526767 0.2087477437672866 24.468593736116624 -7.381064730995589 0.40502923179637546 1.0326067050198386 2.2813641294212503e-21 0.9992283029525422 0.008998743391998857 0.11065499552379345 0.039388051466253834 0.014737339870305356 0.05859063896787352 4.158486242087982e-08 7.381064730995589 -1.0326067050198386 down DAGDK(ub)DKEQELSEEDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAGDKDKEQELSEEDK 16 2 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 38755750.0 12715700.0 22944700.0 3095350.0 True False 10573667.951022813 22821092.346933622 3742573.3737186417 1.0 2.158294780263654 0.35395223219172633 23.33397259124499 -6.733313157509331 1.7109894272811303 1.6944469030075022 0.3543138081260016 0.5746887039560749 0.48680347178738204 0.3300289836948258 1.8942081152791177 0.22532545027575743 0.5570790884123729 1.847935644145786e-07 6.733313157509331 -1.3401330948815007 DAGLK(ub)QAPASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAGLKQAPASR 11 1 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4;K7EL40;K7EK18;K7EQD7;K7ER52;K7EIE4;K7ELJ9;K7ER14;K7EJZ2;K7EJL9;K7ENQ5;K7EN52;K7EKN4;K7EIR4;K7EQ08 Q9UHD8 SEPT9 Septin-9 1 6845860.0 2300410.0 2928200.0 1617250.0 True False 3015859.787202129 2491323.9740342 1449912.4837574302 1.0 0.8260742043135397 0.48076256393290145 21.524137925977712 -6.960188382404599 0.4327773428050572 1.0133190355083652 0.2802148513935789 0.9997771049035318 0.0032217067683682865 0.07963398945298655 0.020883778919926824 0.0045152959166173835 0.028653527083089218 1.0960026837536348e-07 6.960188382404599 -0.7331041841147863 down DAGLK(ub)QAPASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAGLKQAPASR 11 1 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4;K7EL40;K7EK18;K7EQD7;K7ER52;K7EIE4;K7ELJ9;K7ER14;K7EJZ2;K7EJL9;K7ENQ5;K7EN52;K7EKN4;K7EIR4;K7EQ08 Q9UHD8 SEPT9 Septin-9 1 6589700.0 1770100.0 2033700.0 2785900.0 True False 1713909.1444037524 2845767.0156053985 2056189.2147914723 1.0 1.6603954911480476 1.199707243237094 20.708859202466346 -10.267028495122387 4.317173795695672 0.9997054527591703 1.4300513672010862 0.5374418442992535 0.18807518967511955 0.0005335575139913443 9.058741748332819e-05 0.18222614350394156 0.06070100644988484 5.407188438967777e-11 10.267028495122387 0.43034591444191583 DAGLK(ub)QAPASR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DAGLKQAPASR 11 1 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4;K7EL40;K7EK18;K7EQD7;K7ER52;K7EIE4;K7ELJ9;K7ER14;K7EJZ2;K7EJL9;K7ENQ5;K7EN52;K7EKN4;K7EIR4;K7EQ08 Q9UHD8 SEPT9 Septin-9 1 10225030.0 3112100.0 767030.0 6345900.0 True False 4721283.22498576 630147.503667256 5091630.083493229 1.0 0.1334695407241019 1.078441991479676 22.170747600672392 -12.163923934142842 19.082436699110087 0.9553846508077402 0.6453601894917 0.0 0.4379350327412457 0.0 0.0 0.0 0.12760001938581178 6.856082989340416e-13 12.163923934142842 -0.3100244613160401 DAGLK(ub)QAPASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAGLKQAPASR 11 1 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4;K7EL40;K7EK18;K7EQD7;K7ER52;K7EIE4;K7ELJ9;K7ER14;K7EJZ2;K7EJL9;K7ENQ5;K7EN52;K7EKN4;K7EIR4;K7EQ08 Q9UHD8 SEPT9 Septin-9 1 6286510.0 2300410.0 2892100.0 1094000.0 True False 3150933.7432427495 2764317.459104238 835619.7316372455 1.0 0.8773010429154154 0.2651974937363413 21.587347987500603 -6.939856537389274 0.6609029772947148 1.0068878948251672 0.10083035163837656 0.9981449636174532 0.01384258234620055 0.08783232325748855 0.05490949989016291 0.013460040351406613 0.052715987963059305 1.1485329593236763e-07 6.939856537389274 -0.9060575431867905 down DAGLK(ub)QAPASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAGLKQAPASR 11 1 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4;K7EL40;K7EK18;K7EQD7;K7ER52;K7EIE4;K7ELJ9;K7ER14;K7EJZ2;K7EJL9;K7ENQ5;K7EN52;K7EKN4;K7EIR4;K7EQ08 Q9UHD8 SEPT9 Septin-9 1 7802940.0 1770100.0 4546300.0 1486540.0 True False 1471916.5787259426 4521808.17953011 1797368.6410156202 1.0 3.0720546564154363 1.2211076816400706 20.489264477900623 -6.619098577704186 2.1200090727645864 2.375756077065442 1.2281481596209984 0.07969704485572138 0.891265825934107 0.5879174428270294 5.019769062216116 0.3455859599563742 0.9883632821432514 2.4038171111314486e-07 6.619098577704186 -1.1476079174444436 DAGLK(ub)QAPASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DAGLKQAPASR 11 1 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4;K7EL40;K7EK18;K7EQD7;K7ER52;K7EIE4;K7ELJ9;K7ER14;K7EJZ2;K7EJL9;K7ENQ5;K7EN52;K7EKN4;K7EIR4;K7EQ08 Q9UHD8 SEPT9 Septin-9 1 13483200.0 3112100.0 2315200.0 8055900.0 True False 4028674.798662245 2186357.0847756374 6589808.860514283 1.0 0.542698826299317 1.6357261853705551 21.94187392276484 -6.793058674435415 1.4840887341666174 0.7454291642246685 1.6483517369409453 0.8110899785475624 0.19480637696207198 0.23081738522242792 1.004222493642028 0.1033023745487735 0.2413286846762398 1.6104280470124963e-07 6.793058674435415 0.9029225727162767 DAGMQLQGYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAGMQLQGYR 10 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 11112000.0 1948700.0 5632500.0 3530800.0 False True 2554764.571237643 4792152.955313038 3165466.6858251574 1.0 1.8757708672120437 1.2390443806302132 21.284758918194548 -9.893744170074417 5.573811152907348 0.9999996197137023 1.557407623922925 0.505398611491658 0.2599424996464288 1.2285759074422788e-06 2.4357906319585986e-07 0.2516884155372339 0.08389608100759206 1.2771909423492287e-10 9.893744170074417 0.5574080042092228 DAGMQLQGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAGMQLQGYR 10 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 6419620.0 1878900.0 610020.0 3930700.0 False True 1819255.3479578635 853604.1672122743 2901131.751527634 1.0 0.469205253770701 1.5946808977553317 20.794916621042557 -6.778474046068219 1.54190685649323 0.6988479269224487 1.6031566859463426 0.7618954112551166 0.2243248870461956 0.2529681011933853 1.1878416156943827 0.11460138024006344 0.2707478888337324 1.6654283527021235e-07 6.778474046068219 0.904308759023894 DAGMQLQGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAGMQLQGYR 10 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 8480800.0 1948700.0 3129100.0 3403000.0 False True 2669187.051637379 2990846.015450041 2599281.48698496 1.0 1.120508213770685 0.973810166428937 21.34796897971744 -6.6883521113683955 1.8716785943697338 1.0756622366213406 0.9743179221531099 0.3630757493850092 0.050982832591114226 0.4201721979391482 2.8523761476269236 0.021798568084481187 0.05689559870873675 2.0494998394502633e-07 6.6883521113683955 -0.10134431446823078 DAGPLLISLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAGPLLISLK 10 0 P31146 P31146 CORO1A Coronin-1A 0 78365000.0 19730000.0 31326000.0 27309000.0 False True 25866221.06559181 26652282.90779158 24483326.64642552 1.0 1.0303895122602744 0.946536665883295 24.62456596260388 -6.808672298215381 1.4202814954186442 1.016587994361237 0.945116214560467 0.8562910179799719 0.013140043036139831 0.2086162445772478 0.8296754776802497 0.007275491273853481 0.016838699277656084 1.5535588230785982e-07 6.808672298215381 -0.07147177980077002 DAGPLLISLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAGPLLISLK 10 0 P31146 P31146 CORO1A Coronin-1A 0 48946000.0 20060000.0 11487000.0 17399000.0 False True 19423206.280288827 16073819.003913628 12841679.94118841 1.0 0.8275574471052061 0.6611513957003319 24.211278037103533 -6.971560213667406 0.21772070597249926 1.0789823730581876 0.4050400198247012 0.9999921267564897 0.00038813414181299006 0.07579962234645399 0.007190609349210465 0.004690792279918675 0.01694854395259742 1.0676767519987515e-07 6.971560213667406 -0.6739423532334863 DAGPLLISLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DAGPLLISLK 10 0 P31146 P31146 CORO1A Coronin-1A 0 98837000.0 11290000.0 74617000.0 12930000.0 False True 17127755.409559205 61301013.36471801 10374379.832579676 1.0 3.5790453505953956 0.6057057439522758 24.029832762996246 -6.677309258732735 1.9110775692797775 2.6356834292554083 0.6171496909154648 0.3119943036537919 1.0937042433377837 0.4445413305681909 3.1365089687292227 0.45957372191353 1.2164538303430659 2.102280883873558e-07 6.677309258732735 -2.0185337383399435 DAGPLLISLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAGPLLISLK 10 0 P31146 P31146 CORO1A Coronin-1A 0 91616000.0 19730000.0 26589000.0 45297000.0 False True 27024714.183201905 25414210.061935093 34598781.520998485 1.0 0.9404062477645786 1.280264475193025 24.687776024126773 -6.861630605907367 1.1773559769184025 0.967512462384165 1.2972509408354955 0.9555987169344079 0.031222918225322714 0.145137829549291 0.38135061302480777 0.02066864133863335 0.04834248511738556 1.3752111791532464e-07 6.861630605907367 0.32973847845133053 DAGPLLISLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAGPLLISLK 10 0 P31146 P31146 CORO1A Coronin-1A 0 37523100.0 20060000.0 8834900.0 8628200.0 False True 16680778.808678826 8787304.640109647 10432316.727710642 1.0 0.5267922284022919 0.6254094516427987 23.99168331253781 -10.02703576571487 5.960088773832195 1.0000006734561777 0.5761008400225388 0.9609913277067671 0.04026031279837355 3.6027345354977914e-07 5.876907431658037e-08 0.03898194181466049 0.012993960081745831 9.396459241517905e-11 10.02703576571487 -0.4238998334336389 DAGQISGLNVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAGQISGLNVLR 12 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 23635200.0 1496800.0 9509400.0 12629000.0 False True 1962319.2950318197 8090634.587350877 11322272.225922143 1.0 4.122995991444748 5.769841969442872 20.90412837534638 -8.663011932991438 0.3108857749376839 2.5390739036233712e-18 6.5317146600122555 0.9985290734231224 0.07586613189713168 0.2541710743882739 0.09496388501432315 0.8059281007523532 0.5230771404144462 2.172641480964149e-09 8.663011932991438 6.5317146600122555 DAGQISGLNVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAGQISGLNVLR 12 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 26134500.0 9175800.0 3945700.0 13013000.0 False True 8884519.251578994 5521238.586553682 9604504.918368006 1.0 0.6214448334469447 1.0810382246243715 23.08286228231111 -6.687907251678417 1.873948810150993 0.7622021605049646 1.0794058881078978 0.36057612687259244 0.16017151559711104 0.4211985445053944 2.86610904697453 0.06842045086276101 0.17863668079663897 2.0516002736503116e-07 6.687907251678417 0.31720372760293325 DAGQISGLNVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAGQISGLNVLR 12 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 22989800.0 1496800.0 10895000.0 10598000.0 False True 2050207.409499067 10413622.87505296 8094970.672661358 1.0 5.0793021363615845 3.9483667043419888 20.967338436869273 -9.864612193157017 7.156677311610054 0.9999999736865861 4.513834420351804 0.9279092100076554 0.4617024567470752 1.9448244527931807e-07 2.978560867375599e-08 0.4470414814710027 0.14901382715702968 1.3658021965700468e-10 9.864612193157017 3.513834446665218 DAGTIAGLNVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAGTIAGLNVLR 12 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 366961000.0 72081000.0 133160000.0 161720000.0 False True 94498889.033397 113293047.05361454 144986765.7277794 1.0 1.1988823171622205 1.5342695264548494 26.493794032747044 -6.963238421238688 0.38709960288404366 0.9787242856451214 1.766422510918286 0.9998720962349669 0.002493444345749191 0.07856397175535595 0.017000231844459052 0.004338131059920023 0.028247568584892257 1.0883324509026188e-07 6.963238421238688 0.7876982252731647 DAGTIAGLNVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAGTIAGLNVLR 12 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 321328000.0 92077000.0 43001000.0 186250000.0 False True 89154066.03540164 60171523.5472526 137465537.61976802 1.0 0.6749162009432016 1.5418874733675374 26.409797260327 -6.805123320211716 1.4347502446913627 0.8217850031011809 1.555447511980583 0.8467646665750131 0.13998723988389056 0.2135215571957004 0.8671139424625615 0.07673647700100256 0.17794612517718242 1.5663062460255886e-07 6.805123320211716 0.7336625088794022 DAGTIAGLNVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DAGTIAGLNVLR 12 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 519481000.0 37046000.0 446980000.0 35455000.0 False True 56201490.42537912 367212926.72932 28447303.70952149 1.0 6.533864563910146 0.5061663577639827 25.744105054458302 -6.665282505732344 1.9538895745306057 4.546486801431586 0.5308806067208465 0.25833580566842496 2.3532562309024243 0.47208898456330955 3.469862541910006 0.9711421208901343 2.6109110473269714 2.1613121468800804e-07 6.665282505732344 -4.015606194710739 DAGTIAGLNVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAGTIAGLNVLR 12 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 427361000.0 72081000.0 198240000.0 157040000.0 False True 98731293.61578187 189481101.3079848 119950386.34032288 1.0 1.9191595123361866 1.2149176005645814 26.557004094269935 -10.194362170817419 4.737837163587406 0.999913580493841 1.5670385564530487 0.4636375184694743 0.2875055565630517 0.0002624978245737788 4.463590906809949e-05 0.2784182290456363 0.09279201937458204 6.392015643569328e-11 10.194362170817419 0.5671249759592076 DAGTIAGLNVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAGTIAGLNVLR 12 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 173737000.0 92077000.0 43295000.0 38365000.0 False True 76566105.20272794 43061761.24161534 46386944.120282225 1.0 0.5624128474028885 0.6058417624543023 26.190202535761276 -10.121838577402833 7.8913148242245965 1.0000000488778857 0.5841273054357663 0.9918873858118709 0.017729780326440008 1.5226736801024013e-08 1.7180495962936263e-09 0.017166787774676284 0.005722261994684839 7.553729395067852e-11 10.121838577402833 -0.41587274344211944 DAGTIAGLNVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DAGTIAGLNVLR 12 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 149619000.0 37046000.0 71136000.0 41437000.0 False True 47956777.28583318 67177219.06643039 33895891.17952435 1.0 1.4007867681774997 0.7068008548092631 25.51523137655075 -6.750118848029622 1.6495112445791453 1.2356319831682774 0.7054171577456578 0.6494592155159729 0.16841353955831737 0.29982774043751936 1.6051373319807494 0.08065470896098255 0.19577523629516255 1.7777928367635304e-07 6.750118848029622 -0.5302148254226196 DAGTIAGLNVMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 DAGTIAGLNVMR 12 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 184171600.0 41853600.0 60335500.0 81982500.0 False True 54870474.91083896 51333678.585936904 73499737.3316701 1.0 0.9355428155005195 1.339513416843986 25.709526726779796 -6.866057031538442 1.1548282849899147 0.9642883562302668 1.361456960252216 0.9605827144399723 0.035182016422721694 0.14068725563327972 0.3531616091842657 0.023696701063438838 0.0557466318386157 1.3612659093292548e-07 6.866057031538442 0.3971686040219492 DAGTIAGLNVMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAGTIAGLNVMR 12 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 128606000.0 44348000.0 16092000.0 68166000.0 False True 42940197.01486786 22517619.5186714 50311279.66383419 1.0 0.5243948813480006 1.1716592647773398 25.35582547468444 -6.709793667959093 1.7960410159208586 0.7075477714802569 1.1701239173934597 0.4641029916510123 0.2004234229434786 0.37547638019364954 2.360919851414662 0.08881026833624674 0.22566779685322008 1.950771185328585e-07 6.709793667959093 0.46257614591320273 DAGTIAGLNVMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAGTIAGLNVMR 12 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 139423000.0 36983000.0 50320000.0 52120000.0 False True 50656614.52799574 48096696.014012344 39810329.44509442 1.0 0.9494652665237105 0.7858861042340869 25.594247326597955 -6.949730449430249 0.5617984083213446 1.0021195998146515 0.7253899358805095 0.9991799325665902 0.0026168944941587146 0.08359423511662722 0.0364122020806901 0.0027991071194492676 0.013603229028800744 1.1227150659388925e-07 6.949730449430249 -0.276729663934142 DAGVIAGLNVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAGVIAGLNVLR 12 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 166239000.0 30676000.0 62597000.0 72966000.0 False True 40216533.0668066 53257771.60119491 65416178.259294875 1.0 1.324275553855539 1.6265991439547343 25.26128538128717 -6.971969062646032 0.20578949257976392 0.8329604722364168 2.126314436565898 0.999993940561018 0.0006297975294010943 0.07566880052548493 0.006692734028879024 0.009363352057147323 0.03164055216164045 1.0666721038606048e-07 6.971969062646032 1.2933539643294811 DAGVIAGLNVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAGVIAGLNVLR 12 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 145413000.0 51458000.0 21695000.0 72260000.0 False True 49824493.95668517 30357926.63793039 53332938.24646679 1.0 0.609297239713503 1.0704160546584112 25.570351816593718 -6.682168608494298 1.8938997746756256 0.7532766502464722 1.0687007402556723 0.33408048532118995 0.16551215538311323 0.433795114387104 3.0100597721729985 0.07007165628178043 0.18431653223649416 2.0788894319296712e-07 6.682168608494298 0.31542409000920013 DAGVIAGLNVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DAGVIAGLNVLR 12 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 505546000.0 33006000.0 308710000.0 163830000.0 False True 50072515.06181678 253618288.5377609 131448928.69076002 1.0 5.065019966036411 2.6251712846554716 25.57751558570237 -9.556636702043178 9.381710856279286 1.0000000000484033 3.845095625345956 0.6445123296722648 0.9960640531642819 0.0 0.0 0.9644348724152795 0.32147829080509305 2.775641025372072e-10 9.556636702043178 2.845095625297553 DAGVIAGLNVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAGVIAGLNVLR 12 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 140465000.0 30676000.0 51523000.0 58266000.0 False True 42017746.18772942 49246543.49622338 44504770.825937666 1.0 1.1720415292195043 1.0591898629473502 25.32449544281006 -10.347128006480606 4.83543003238373 0.9999194436184607 1.1156156960834884 0.5832372589709212 0.046071499831816624 4.003792570575582e-05 5.405768970825473e-06 0.04463958383449135 0.01486951263192188 4.496473036992286e-11 10.347128006480606 0.11569625246502768 DAGVIAGLNVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAGVIAGLNVLR 12 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 102610000.0 51458000.0 21601000.0 29551000.0 False True 42789606.97592208 21484631.125537205 35729977.47161368 1.0 0.5020992863436842 0.8350153225693127 25.350757092027994 -10.160535605293553 7.506433220255951 1.0000001655865205 0.6685573044564984 0.5692547748087657 0.13591240265711832 3.7663200560972123e-07 4.232009712706613e-08 0.13159668271854522 0.04386553933617133 6.909782777688283e-11 10.160535605293553 -0.3314428611300221 DAGVIAGLNVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DAGVIAGLNVLR 12 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 316696000.0 33006000.0 176400000.0 107290000.0 False True 42726917.645527475 166583184.93193763 87764320.8883647 1.0 3.898787792603033 2.0540756442221757 25.348641907794818 -10.052605921546057 6.213251564415526 0.9999974327441103 2.9764317184126443 0.6048276849782075 0.7531005809745474 2.6782274202195223e-05 4.081706481182727e-06 0.7291874463462145 0.24306216734444172 8.859191275041684e-11 10.052605921546057 1.976434285668534 DAHLLVESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAHLLVESK 9 0 P42704 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 13886600.0 3163400.0 5934900.0 4788300.0 False True 4147248.0344091817 5049436.054059007 4292852.648616908 1.0 1.2175389588865888 1.0351087306569715 21.983722902391843 -13.975291933034477 10.955492313384406 0.9900719923526001 1.1136914577214279 0.0 0.09980864366369305 0.0 0.0 0.0 0.027556814430462952 1.0585419333914273e-14 13.975291933034477 0.12361946536882773 DAHLLVESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DAHLLVESK 9 0 P42704 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 19904200.0 4123900.0 13315000.0 2465300.0 False True 6256257.797473973 10938834.219430173 1978032.3744206224 1.0 1.7484628309029782 0.31616861683981007 22.576868531373908 -6.7646776510461555 1.594563363483501 1.432205344614104 0.30963448103784824 0.7098849630526642 0.31505695261962474 0.2751263060641518 1.3796387703184207 0.1558107109513927 0.3727740047475726 1.719183953755441e-07 6.7646776510461555 -1.122570863576256 DAHLLVESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAHLLVESK 9 0 P42704 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 12095300.0 3163400.0 3946000.0 4985900.0 False True 4332994.4676706 3771652.672322991 3808333.1078337715 1.0 0.8704494548663977 0.8789148327440898 22.046932963914735 -10.368714219419436 8.266014899857497 1.0000007582200916 0.8746821438054404 0.9965892846719208 0.0034559760466983972 4.829220572203928e-08 3.6857574672430215e-09 0.0033462546621396256 0.0011154114728128917 4.2784432970213833e-11 10.368714219419436 -0.1253186144146512 DAHLLVESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAHLLVESK 9 0 P42704 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 6870500.0 2020500.0 3153400.0 1696600.0 False True 1680135.2733267988 3136412.0082991077 2051351.2158079215 1.0 1.866761598361522 1.2209440801430744 20.680145963221726 -10.214839066803801 4.712266166133043 0.9999003842702249 1.5438528392418573 0.48600502912901256 0.2636538978227537 0.00030070359140419936 5.0103566821941385e-05 0.2553323748920947 0.08509392961045113 6.097628105375147e-11 10.214839066803801 0.5439524549716325 DAHSIHGTNPQYLVEK(ub)IIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAHSIHGTNPQYLVEKIIR 19 1 Q8NAV1 Q8NAV1 PRPF38A Pre-mRNA-splicing factor 38A 1 13439000.0 5554400.0 4993800.0 2890800.0 True False 4618729.701641365 4966897.4082083125 3495252.9144509793 1.0 1.0753817021254175 0.756756324841626 22.139064688251555 -6.8443153824710885 1.2621568879133738 1.0401089184792798 0.7453460439101856 0.9316223235665628 0.03555298347448409 0.16382478713561485 0.505072819213031 0.022069938236341714 0.05092074363163959 1.431148229162954e-07 6.8443153824710885 -0.2947628745690942 DAHVDFLK(ub)SGDSHLGGGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAHVDFLKSGDSHLGGGSR 19 1 Q9NVM9;Q9NVM9-2 Q9NVM9 ASUN Protein asunder homolog 1 14943600.0 3973500.0 5020700.0 5949400.0 True False 5209296.97942874 4271631.130535317 5333813.158674574 1.0 0.8200014603513257 1.023902683939415 22.31265725608374 -6.673618393490721 1.9241636216947262 0.8854716410211472 1.0231005965659843 0.295388323067599 0.07639542560065836 0.45283210181360833 3.235508981682676 0.03192158976934277 0.08489795629115708 2.1202233179157773e-07 6.673618393490721 0.13762895554483712 DAHVDFLK(ub)SGDSHLGGGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAHVDFLKSGDSHLGGGSR 19 1 Q9NVM9;Q9NVM9-2 Q9NVM9 ASUN Protein asunder homolog 1 15241600.0 2252300.0 3149800.0 9839500.0 True False 2180801.9693466905 4407531.565990006 7262239.771327284 1.0 2.0210599714885547 3.330077592282648 21.05642733938873 -6.9677354212029785 0.30751049571105077 0.7923135400630696 4.600284190241325 0.9999589383812089 0.006111042018993687 0.07704461890330903 0.01164704457023546 0.02094851997044187 0.11649960087485171 1.0771212123956489e-07 6.9677354212029785 3.8079706501782553 DAHVDFLK(ub)SGDSHLGGGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DAHVDFLKSGDSHLGGGSR 19 1 Q9NVM9;Q9NVM9-2 Q9NVM9 ASUN Protein asunder homolog 1 58725900.0 7637900.0 12215000.0 38873000.0 True False 11587252.705285419 10035137.813769393 31189734.51135883 1.0 0.8660497935970584 2.6917281692779444 23.466035213447203 -6.889241554261687 1.0268185805663872 0.9001136152787572 2.8464632853701 0.9804098437536407 0.11629149820013428 0.11976231130179689 0.22543943651511353 0.08637552245027692 0.21476417212959387 1.2905012981193738e-07 6.889241554261687 1.9463496700913427 up DAHVDFLK(ub)SGDSHLGGGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAHVDFLKSGDSHLGGGSR 19 1 Q9NVM9;Q9NVM9-2 Q9NVM9 ASUN Protein asunder homolog 1 16109800.0 3973500.0 3577200.0 8559100.0 True False 5442610.329799938 3419147.4757814985 6537616.860197769 1.0 0.628218312279428 1.2011914254456797 22.37586731760663 -6.731632796234589 1.7180082585291312 0.7766616385263317 1.2009065618801706 0.5665106711550351 0.15626833634224402 0.33317930072891133 1.92743652996633 0.07207104394195102 0.17845983000472743 1.855099480343044e-07 6.731632796234589 0.4242449233538389 DAHVDFLK(ub)SGDSHLGGGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAHVDFLKSGDSHLGGGSR 19 1 Q9NVM9;Q9NVM9-2 Q9NVM9 ASUN Protein asunder homolog 1 14689000.0 2252300.0 4522500.0 7914200.0 True False 1872887.243807946 4498136.394854036 9569022.628873639 1.0 2.4017123346456484 5.109235839215789 20.836832614823006 -6.960719899656411 0.42516676594187564 0.886774254507777 6.727179114201636 0.9997959730994451 0.024362286948200862 0.07944496054147723 0.02018853120763092 0.035155026105856746 0.2250721456779665 1.0946621463379965e-07 6.960719899656411 5.840404859693859 DAHVDFLK(ub)SGDSHLGGGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DAHVDFLKSGDSHLGGGSR 19 1 Q9NVM9;Q9NVM9-2 Q9NVM9 ASUN Protein asunder homolog 1 85867600.0 7637900.0 8795700.0 69434000.0 True False 9887412.115517616 8306211.5629583085 56797724.453003325 1.0 0.8400794329106883 5.744447969743588 23.237161535539652 -6.899363918490352 0.9653030628922966 0.7925202508542706 6.2526044850001465 0.9862465271695999 0.2668227524056503 0.11187422286727632 0.18008217077570912 0.2075620455360636 0.5383247813791384 1.2607706249377535e-07 6.899363918490352 5.460084234145876 up DAIAQAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAIAQAVR 8 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 10838500.0 3241900.0 1388800.0 6207800.0 False True 3138987.6590263406 1943355.082496326 4581790.94999193 1.0 0.6191024921388576 1.4596396824997784 21.581867926279724 -6.783495198782137 1.5221708596503984 0.7853064444579403 1.4670527382454914 0.7795944466791755 0.16133436423116665 0.24517816934941775 1.1222302216561786 0.08346030618124027 0.19637068581271813 1.6462841662492848e-07 6.783495198782137 0.6817462937875511 DAIHFYNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAIHFYNK 8 0 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 25792600.0 7298500.0 9374400.0 9119700.0 False True 9568404.178774543 7975776.061124996 8176080.92633955 1.0 0.8335534235497231 0.8544874122767969 23.18984690100045 -9.679385629728248 6.352275904564275 1.0000000012194437 0.8440204179933811 0.9866708569287017 0.008546265111785634 7.643382049383764e-11 1.9411217470730863e-11 0.00827488561195062 0.0027582952039835397 2.092253823917938e-10 9.679385629728248 -0.15597958322606253 DAIHFYNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAIHFYNK 8 0 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 21582300.0 7298500.0 6670800.0 7613000.0 False True 9996952.684546325 6376061.998614341 5814966.194656634 1.0 0.637800557811052 0.5816738738441398 23.253056962523342 -13.999999999999998 0.2624833997544183 3.686158598449924 0.5616427014527781 0.9995674415957692 0.0038558083474166923 14.528238545528021 0.16213463592402524 20.730859251186896 0.02422083487726797 1.0000000000000041e-14 13.999999999999998 -3.124515896997146 DAISAGK(ub)NWMFSNAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAISAGKNWMFSNAK 15 1 Q8IWX8;J3QK89 Q8IWX8 CHERP Calcium homeostasis endoplasmic reticulum protein 1 6823900.0 0.0 3083100.0 3740800.0 True False 0.0 2623113.497829675 3353737.900287399 0.0 DAISAGK(ub)NWMFSNAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAISAGKNWMFSNAK 15 1 Q8IWX8;J3QK89 Q8IWX8 CHERP Calcium homeostasis endoplasmic reticulum protein 1 3897000.0 3897000.0 0.0 0.0 True False 3773291.8681099503 0.0 0.0 1.0 0.0 0.0 21.847392267773028 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 DAITQALFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAITQALFLR 10 0 Q9UNX4 Q9UNX4 WDR3 WD repeat-containing protein 3 0 2610420.0 617510.0 651210.0 1341700.0 False True 809561.5899753474 554052.0063966985 1202873.7544951886 1.0 0.6843852441338903 1.4858335293943705 19.62678131675827 -6.799874172297075 1.4564147176989788 0.825833078040351 1.4968639198289424 0.8317967017994059 0.13519415993122383 0.22093833031978743 0.9252265130891433 0.07302662964731703 0.16984693170405582 1.5853524484965234e-07 6.799874172297075 0.6710308417885914 DAK(ub)AAMAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAKAAMAGR 9 1 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 4607300.0 1108200.0 1756200.0 1742900.0 True False 1073020.797598012 2457459.818462012 1286382.20412077 1.0 2.290225710408509 1.198841818350934 20.033246608420225 -6.605207587954352 2.1710550037156864 1.8647497723677053 1.2025527421543407 0.03583238637798691 0.5569352982139619 0.6260379943365855 5.584275354579128 0.21233982412783375 0.6189613145593164 2.48194647878133e-07 6.605207587954352 -0.6621970302133646 DAK(ub)AAMAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAKAAMAGR 9 1 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 2010250.0 1108200.0 0.0 902050.0 True False 921517.4015841432 0.0 1090664.4843920378 1.0 0.0 1.183552782093014 19.8136518838545 -10.759067832763003 6.194776657747542 1.0131333994098692 0.591776391046507 0.13690472848161706 0.48318339996322196 0.08739566824938566 0.0033990580440225603 0.46652073356675555 0.15594677176845304 1.7415348405863295e-11 10.759067832763003 -0.4213570083633622 DAK(ub)ACVVHGSDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DAKACVVHGSDLK 13 1 P05023-4;P05023;P05023-3 P05023-4 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 1 53099800.0 6577800.0 14052000.0 32470000.0 True False 8515091.767822541 13269993.84729926 26560793.170334674 1.0 1.558408788669183 3.119260942166773 23.021590647351196 -6.953028667836815 0.5245402483977717 0.9743774524779059 3.7734904087635215 0.9994180351722602 0.0216359908256882 0.08229188281678494 0.031101880048431372 0.02433738295404929 0.12898898477747786 1.1142209812882135e-07 6.953028667836815 2.7991129562856156 DAK(ub)HTNFVEFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAKHTNFVEFR 11 1 M0R0N4;M0QYZ2;P53680;M0QZ21 M0R0N4 AP2S1 AP-2 complex subunit sigma 1 40468200.0 10358000.0 8661200.0 21449000.0 True False 13579438.307014689 7368982.721093175 19229663.233336255 1.0 0.542657402647251 1.4160867922941147 23.694920470123808 -6.764439709950384 1.5959370419724899 0.7358199831066715 1.4199777438456984 0.7087693948574436 0.1925006112677449 0.27551667837581323 1.384010759448447 0.09513034811166822 0.22760607570445043 1.7201261176796034e-07 6.764439709950384 0.6841577607390269 DAK(ub)HTNFVEFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAKHTNFVEFR 11 1 M0R0N4;M0QYZ2;P53680;M0QZ21 M0R0N4 AP2S1 AP-2 complex subunit sigma 1 76343800.0 10758000.0 9005800.0 56580000.0 True False 10416493.178631479 12601862.904626569 41760000.63638377 1.0 1.2097989878664908 4.00902683083888 23.312366325193523 -6.9219217523455825 0.8103523015248192 0.942409104731676 4.4809929292303865 0.9946981367020162 0.0998784850886911 0.09705436326833991 0.09985357065929247 0.08694281786063057 0.26541573405551355 1.1969561697271877e-07 6.9219217523455825 3.5385838244987102 up DAK(ub)HTNFVEFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DAKHTNFVEFR 11 1 M0R0N4;M0QYZ2;P53680;M0QZ21 M0R0N4 AP2S1 AP-2 complex subunit sigma 1 254661000.0 20085000.0 79536000.0 155040000.0 True False 30470413.41018571 65342179.38239571 124396276.04355387 1.0 2.14444676226654 4.082526691350057 24.860905738268713 -6.963163416366764 0.388290126939673 0.8786789380447729 5.417740719590063 0.999870129463643 0.014498806386211767 0.07858990132857904 0.017093073483807522 0.025048544458640163 0.16314739209412474 1.0885204276991873e-07 6.963163416366764 4.53906178154529 DAK(ub)HTNFVEFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAKHTNFVEFR 11 1 M0R0N4;M0QYZ2;P53680;M0QZ21 M0R0N4 AP2S1 AP-2 complex subunit sigma 1 58281000.0 10358000.0 10095000.0 37828000.0 True False 14187632.514424996 9648969.520299181 28893805.492114946 1.0 0.6800972262629992 2.036548766169249 23.7581305316467 -6.844532533044617 1.261210763549553 0.8297871624371757 2.085309661646909 0.9319634219397583 0.15101439069083253 0.16357271017572392 0.5034515395633332 0.09381315210646199 0.21645978102116203 1.430432822935602e-07 6.844532533044617 1.2555224992097331 up DAK(ub)HTNFVEFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAKHTNFVEFR 11 1 M0R0N4;M0QYZ2;P53680;M0QZ21 M0R0N4 AP2S1 AP-2 complex subunit sigma 1 63575000.0 10758000.0 19361000.0 33456000.0 True False 8945753.66020773 19256698.450142413 40451494.91693375 1.0 2.152607726702733 4.521865507751353 23.0927716006278 -6.959505290434335 0.44235039427809425 0.9173317640795408 5.849876872577659 0.9997514100754481 0.023115836582042498 0.07987831286804865 0.021787835572761954 0.03133082457883686 0.19622271102027997 1.0977279180272707e-07 6.959505290434335 4.932545108498118 DAK(ub)HTNFVEFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DAKHTNFVEFR 11 1 M0R0N4;M0QYZ2;P53680;M0QZ21 M0R0N4 AP2S1 AP-2 complex subunit sigma 1 247439000.0 20085000.0 95694000.0 131660000.0 True False 26000428.434539746 90368544.77821335 107699230.94568098 1.0 3.4756559879669164 4.142209856919515 24.632032060361162 -9.622380542603093 0.36928031107792714 1.492250368657913e-19 4.268011421766373 0.9984957215436415 0.052430207679734706 0.9635234130783396 0.15474820097588746 1.377517069477493 0.1840195969156215 2.3857199233050916e-10 9.622380542603093 4.268011421766373 DALAK(ub)HIYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DALAKHIYAK 10 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 8874600.0 1065400.0 2233300.0 5575900.0 True False 1616289.6911731057 1834750.166147456 4473820.920996211 1.0 1.1351617078098117 2.7679573441745484 20.62425436800967 -6.923297814023091 0.7998895360896977 0.9680736297730668 3.0523238155895256 0.9950490295954271 0.05653411633226065 0.09626990529178152 0.09584319922526219 0.0495809012783697 0.15354202917660315 1.1931696171859364e-07 6.923297814023091 2.084250185816459 up DALAK(ub)HIYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DALAKHIYAK 10 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 6722200.0 1065400.0 1546600.0 4110200.0 True False 1379181.302173693 1460530.3504293365 3362185.774213409 1.0 1.0589835782485097 2.437812758130024 20.39538069010212 -6.915878225583151 0.8547312714699974 0.9648280087712291 2.6403717174180286 0.9929574063820551 0.05575029755289096 0.10065820522548544 0.11862785052743093 0.04701414010111006 0.13572985062428383 1.213729127496773e-07 6.915878225583151 1.6755437086467995 up DALEK(ub)NQQWLVYDQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DALEKNQQWLVYDQQR 16 1 Q53EZ4;Q53EZ4-2;H0Y432 Q53EZ4 CEP55 Centrosomal protein of 55 kDa 1 7657400.0 1677200.0 2679000.0 3301200.0 True False 2198825.4420279046 2279303.6426602122 2959623.491346436 1.0 1.036600540949756 1.3460020221600093 21.068301646951987 -6.92908339273425 0.7542676573391304 0.9951317421567908 1.40806511197966 0.9963552795379286 0.009369721182542501 0.09311609078623527 0.08002914327150656 0.00849026258263913 0.028137801901000566 1.1773798726648063e-07 6.92908339273425 0.4129333698228691 DALEK(ub)NQQWLVYDQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DALEKNQQWLVYDQQR 16 1 Q53EZ4;Q53EZ4-2;H0Y432 Q53EZ4 CEP55 Centrosomal protein of 55 kDa 1 12533000.0 2249200.0 5678700.0 4605100.0 True False 2177800.3771498324 7946234.524029287 3398886.1599613116 1.0 3.648743295025422 1.5606968368742589 21.05444028825743 -6.586581402818551 2.242501984539346 2.796548222482288 1.5665469015417293 0.0 1.148790575983474 0.679527398077554 6.437489578518976 0.42857270262569835 1.281166577120135 2.5907087813770645e-07 6.586581402818551 -1.230001320940559 DALEK(ub)NQQWLVYDQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DALEKNQQWLVYDQQR 16 1 Q53EZ4;Q53EZ4-2;H0Y432 Q53EZ4 CEP55 Centrosomal protein of 55 kDa 1 25225900.0 4979100.0 12224000.0 8022800.0 True False 7553658.720968663 10042531.693452068 6437090.0634818375 1.0 1.3294923777234455 0.8521817441411175 22.84874417270929 -6.720965090850985 1.7556804680003928 1.2002494241770354 0.8528765374895808 0.5171471133696144 0.1386352748023344 0.35344282044191605 2.129637518291352 0.06268362876439243 0.15719064794141083 1.9012310971822175e-07 6.720965090850985 -0.3473728866874546 DALEK(ub)NQQWLVYDQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DALEKNQQWLVYDQQR 16 1 Q53EZ4;Q53EZ4-2;H0Y432 Q53EZ4 CEP55 Centrosomal protein of 55 kDa 1 7065300.0 1677200.0 3102400.0 2285700.0 True False 2297306.1646257583 2965325.709735134 1745864.7354691545 1.0 1.2907838560639562 0.759961716184035 21.13151170847488 -6.7579584103886905 1.6199968665992774 1.1693326646735764 0.75820606800559 0.6826146360069927 0.12227209330860672 0.28637398862355146 1.4807420568102598 0.05956321633830912 0.14343887628045326 1.7459893471734766e-07 6.7579584103886905 -0.41112659666798645 DALEK(ub)NQQWLVYDQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DALEKNQQWLVYDQQR 16 1 Q53EZ4;Q53EZ4-2;H0Y432 Q53EZ4 CEP55 Centrosomal protein of 55 kDa 1 9562100.0 2249200.0 4985400.0 2327500.0 True False 1870309.4564546573 4958542.6606755825 2814169.488855907 1.0 2.6511883600668704 1.5046544726295845 20.834845563691708 -10.500447012147 5.412988167622873 0.9978693996309982 2.0779214163472473 0.5409740226308843 0.468070499505173 0.01205068326085467 0.001112130138356879 0.4537804897399872 0.15106910411954147 3.1590244544538635e-11 10.500447012147 1.080052016716249 DALEK(ub)NQQWLVYDQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DALEKNQQWLVYDQQR 16 1 Q53EZ4;Q53EZ4-2;H0Y432 Q53EZ4 CEP55 Centrosomal protein of 55 kDa 1 14656100.0 4979100.0 9677000.0 0.0 True False 6445543.102734219 9138466.443233332 0.0 1.0 1.4177961884013723 0.0 22.619870494801738 -6.85388339885466 1.397296443676924 1.2216262955959836 9.880748693285807e-21 0.9005135086784473 0.18762687484923019 0.17099067170691087 0.6709916924786741 0.10808441291223411 0.22723508289119798 1.3999631399062512e-07 6.85388339885466 -1.2216262955959836 down DALEPGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DALEPGQR 8 0 P07741-2;P07741;H3BQB1;H3BQZ9 P07741-2 APRT Adenine phosphoribosyltransferase 0 3101300.0 1107400.0 355600.0 1638300.0 False True 1072246.1931601143 497592.93442950275 1209180.0820535086 1.0 0.46406593709883115 1.1277075076292171 20.032204763247027 -6.6918344052608845 1.8600360812925856 0.6645760486080394 1.1254557835830146 0.37893364857701306 0.22657969093007857 0.41275381048187965 2.7701185893921614 0.09740167264310803 0.2530428881683126 2.0331320882474156e-07 6.6918344052608845 0.46087973497497514 DALLAHGTSFLLHDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DALLAHGTSFLLHDR 15 0 Q9H9Y6;Q9H9Y6-3;Q9H9Y6-2;Q9H9Y6-4;Q9H9Y6-5 Q9H9Y6 POLR1B DNA-directed RNA polymerase I subunit RPA2 0 7449900.0 2311100.0 3232000.0 1906800.0 False True 3029874.4807242397 2749798.1982373246 1709502.627317154 1.0 0.9075617540367653 0.5642156591610774 21.530826597415942 -6.94657857046744 0.5952224240648545 1.0039115552917348 0.4504334736690967 0.9989046979795504 0.006204719015656855 0.0848894078970299 0.04187749501960106 0.006398537116504965 0.028809913367236564 1.130892775147377e-07 6.94657857046744 -0.5534780816226381 DALLAHGTSFLLHDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DALLAHGTSFLLHDR 15 0 Q9H9Y6;Q9H9Y6-3;Q9H9Y6-2;Q9H9Y6-4;Q9H9Y6-5 Q9H9Y6 POLR1B DNA-directed RNA polymerase I subunit RPA2 0 5842900.0 2311100.0 1922900.0 1608900.0 False True 3165576.1251291404 1837939.9198200381 1228910.9563356165 1.0 0.5806020285628288 0.38821083675107726 21.594036658938833 -13.999999999999982 0.10468900105239612 3.0457415010247044 0.006674068384323681 0.9997700546203698 0.0038733057862285173 12.04648833648796 0.09727294127278818 5.265367433981572 0.33948786125529345 1.0000000000000409e-14 13.999999999999982 -3.0390674326403806 DALNIETAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DALNIETAIK 10 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 51091000.0 10501000.0 23783000.0 16807000.0 False True 13766912.691828646 20234669.10540791 15067972.86412808 1.0 1.4698044186347023 1.0945063139008413 23.71470172741909 -10.263123766990129 5.180593016697267 0.9999570453148352 1.2821553662678054 0.42975678893651226 0.15321480967214396 7.602932944114786e-05 1.0814269258747789e-05 0.14837214653260528 0.0494498671876814 5.456023509785385e-11 10.263123766990129 0.28219832095297015 DALNIETAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DALNIETAIK 10 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 49042400.0 14730000.0 9790400.0 24522000.0 False True 14262404.212794356 13699757.776261525 18098952.555768866 1.0 0.9605503792952315 1.2689973082892199 23.765713861527203 -6.874776941474297 1.1084585129259463 0.9768917582678194 1.288784921756548 0.9692252508375037 0.024043098247044637 0.1323600074162392 0.30106873420477476 0.016779296913160494 0.04009166888020612 1.3342065196737885e-07 6.874776941474297 0.31189316348872853 DALNIETAIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DALNIETAIK 10 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 108205000.0 11985000.0 75900000.0 20320000.0 False True 18182121.220865123 62355051.99059332 16303743.0934276 1.0 3.429470699988349 0.8966909248585382 24.11601718587238 -6.655626208756854 1.9884657625083282 2.5694093288410365 0.9073154028685225 0.21719637705203165 1.0355021722842739 0.49487331735541606 3.7567594714938903 0.42141665662596584 1.1473938834637534 2.2099059501575472e-07 6.655626208756854 -1.6620939259725138 DALNIETAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DALNIETAIK 10 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 52204000.0 10501000.0 16846000.0 24857000.0 False True 14383503.478854677 16101688.017727599 18986288.54598447 1.0 1.1194552176664636 1.3200044463364846 23.77791178894198 -6.963317908457662 0.38583740480379536 0.987097127634914 1.4595206240674865 0.9998741546194995 0.0014811362860605996 0.07853653430954578 0.0169022529558502 0.0025964159496012435 0.01690046523465967 1.0881332759020813e-07 6.963317908457662 0.47242349643257253 DALNIETAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DALNIETAIK 10 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 32448500.0 14730000.0 8201900.0 9516600.0 False True 12248647.649643043 8157714.736750321 11506477.060213163 1.0 0.6660094216187252 0.9394079566447886 23.54611913696148 -9.969237710090336 6.4559168679620225 1.0000000437111574 0.8027086891317526 0.40979417311094557 0.11161448453973054 7.02673878930849e-08 1.1224863958517757e-08 0.10807028411001175 0.03602341998482285 1.0734017275439745e-10 9.969237710090336 -0.19729135457940472 DALNIETAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DALNIETAIK 10 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 60442000.0 11985000.0 34836000.0 13621000.0 False True 15514818.759669362 32897345.976694927 11142117.763262343 1.0 2.120382228518924 0.7181597114254523 23.88714350796483 -6.693952646941314 1.8526894532711904 1.6998199641588623 0.7228141712451996 0.38877588573860644 0.4734742569522106 0.4082658898035273 2.72002777859254 0.20422921649175646 0.5291303436402639 2.023239769481545e-07 6.693952646941314 -0.9770057929136626 DALNQATSQVESK(ub)QNAELAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DALNQATSQVESKQNAELAK 20 1 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 1 6749200.0 2097800.0 2331800.0 2319600.0 True False 2031206.4872776642 3262899.9001763617 1712027.1734916184 1.0 1.6063851315035338 0.842862202447065 20.953905477116386 -6.695109880234059 1.8484283284802405 1.3783373019797058 0.8453405934813447 0.39433314048558576 0.25619973306777183 0.40579459450175154 2.6919595347064926 0.1107253042268508 0.2864751108266571 2.0178557642516263e-07 6.695109880234059 -0.5329967084983611 DALPEK(ub)ACQLDSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DALPEKACQLDSR 13 1 E9PJM3;Q9UK99-3;Q9UK99-2;Q9UK99;G3V1E0;Q49AF1 E9PJM3 FBXO3 F-box only protein 3 1 28312300.0 5440700.0 3542900.0 19328700.0 True False 8253939.668448963 2910641.8141959575 15508373.97292983 1.0 0.3526366718334531 1.8789056615244295 22.9766514624368 -6.791463964648264 1.4903566711951868 0.638864705406415 1.895822160240051 0.8060361913575108 0.2754706181530437 0.23319585051325184 1.0232019851406897 0.14546992693049104 0.34023909294539784 1.616352336510985e-07 6.791463964648264 1.256957454833636 DALPEK(ub)ACQLDSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DALPEKACQLDSR 13 1 E9PJM3;Q9UK99-3;Q9UK99-2;Q9UK99;G3V1E0;Q49AF1 E9PJM3 FBXO3 F-box only protein 3 1 3855700.0 1354000.0 1015000.0 1486700.0 True False 1854610.3904741686 970153.9438438496 1135572.0795476185 1.0 0.5231039084148613 0.6122968389373072 20.822684712090847 -10.076219181405417 5.27398676830606 1.0000058046611549 0.5677003736755509 0.969061188882715 0.03641286140923112 2.4853257555865886e-06 4.3527620579996493e-07 0.03525707463219567 0.0117522004851903 8.390364315222528e-11 10.076219181405417 -0.4323054309856039 DALPEK(ub)ACQLDSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DALPEKACQLDSR 13 1 E9PJM3;Q9UK99-3;Q9UK99-2;Q9UK99;G3V1E0;Q49AF1 E9PJM3 FBXO3 F-box only protein 3 1 28863300.0 5440700.0 3123700.0 20298900.0 True False 7043093.402230542 2949863.3490470177 16604708.484302603 1.0 0.4188306445166265 2.3575874315459036 22.747777784529248 -6.826344487254447 1.3441784314934906 0.6885969772875364 2.40596523409676 0.8983661700373435 0.25898567007557477 0.18536155141808544 0.6562787183612024 0.1513336111548179 0.3483574201028797 1.4916107778059767e-07 6.826344487254447 1.7173682568092234 up DALSDLALHFLNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DALSDLALHFLNK 13 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 36291600.0 9093200.0 17925500.0 9272900.0 False True 11921273.25867405 15251085.273051726 8313429.2599377055 1.0 1.2793168097170216 0.6973608506028299 23.507034996142018 -6.776195981392243 1.5507359806528116 1.1589376239315599 0.693292442991311 0.753686826561971 0.1179436418773658 0.2565287640148338 1.2181977715138628 0.05992134086777616 0.14184281566837995 1.6741872054015798e-07 6.776195981392243 -0.46564518094024887 DALSDLALHFLNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DALSDLALHFLNK 13 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 60088300.0 10091800.0 38653600.0 11342900.0 False True 15309998.409405626 31755563.07804474 9100970.843230322 1.0 2.07417154651929 0.5944462304868159 23.867970797164016 -6.712025113277087 1.7881895451817116 1.6590091445444917 0.5977400488430128 0.47465016249601466 0.45250875036217997 0.371005339937463 2.3138303973758316 0.2012936774636623 0.5100897537000232 1.9407736482239238e-07 6.712025113277087 -1.061269095701479 DALSDLALHFLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DALSDLALHFLNK 13 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 94355200.0 9093200.0 18075500.0 67186500.0 False True 12455201.774490172 17276864.64231479 51318432.44940208 1.0 1.3871204140345599 4.120240954627384 23.57024505766491 -6.9324975550070524 0.7259966340397962 0.9620456540609635 4.718777804428007 0.9970067833994519 0.07597471079239126 0.09136151565212643 0.07147751921879 0.07027506145254307 0.24399270206610896 1.168160306356744e-07 6.9324975550070524 3.7567321503670437 up DALSDLALHFLNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DALSDLALHFLNK 13 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 93597500.0 63814100.0 14168400.0 15615000.0 False True 53064251.59396371 14092072.016992798 18880024.3043974 1.0 0.26556620688485943 0.355795544783394 25.66123693547731 -10.661346232519021 6.722282382480411 1.0036466499077374 0.31068087585384735 0.9873126517070203 0.036835972946762975 0.0020173997363774504 0.00010163208341861294 0.03574085339898373 0.011888759147013327 2.1809904678915897e-11 10.661346232519021 -0.6929657740538901 DALSDLALHFLNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DALSDLALHFLNK 13 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 43291400.0 10091800.0 20767500.0 12432100.0 False True 13064034.039118154 19611770.368900303 10169585.364118177 1.0 1.5012032508623296 0.7784414319242422 23.639097119256466 -6.720207127929359 1.758816550574463 1.304862244801512 0.779573582422407 0.5133943723268735 0.21090269553262236 0.35490957559032743 2.1457998835544134 0.09521261623993942 0.23893881106215298 1.904552163863473e-07 6.720207127929359 -0.5252886623791049 DAMMAK(ub)AEYLCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAMMAKAEYLCR 12 1 Q15008;Q15008-4;Q15008-3;Q15008-2;C9J7B7;C9J0E9 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 1 7632600.0 2557700.0 2792600.0 2282300.0 True False 3353169.468802032 2375954.9654695396 2046149.4893674941 1.0 0.7085699030649899 0.6102135631392679 21.677093967941072 -13.999999999999998 0.15168578198823893 2.4129699473537043 0.5040716463300604 0.9995607096359671 0.0034689396342490655 11.964459084668553 0.12274288518737446 4.980453120099025 0.09583012354703993 1.0000000000000041e-14 13.999999999999998 -1.908898301023644 DAMMAK(ub)AEYLCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DAMMAKAEYLCR 12 1 Q15008;Q15008-4;Q15008-3;Q15008-2;C9J7B7;C9J0E9 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 1 85063600.0 7680600.0 19828000.0 57555000.0 True False 11652031.727073558 16289538.48312891 46179229.02274733 1.0 1.3979998393996886 3.963191150213713 23.474078199091945 -6.934340495500557 0.7102681165434007 0.9665593856125401 4.553158743187593 0.9973245140344985 0.06792247737172039 0.09044616019409941 0.06709481317578514 0.06356376491704036 0.226822554743178 1.1632136891726193e-07 6.934340495500557 3.5865993575750528 up DAMMAK(ub)AEYLCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAMMAKAEYLCR 12 1 Q15008;Q15008-4;Q15008-3;Q15008-2;C9J7B7;C9J0E9 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 1 8911600.0 2557700.0 2844400.0 3509500.0 True False 3503350.8092435594 2718725.002827044 2680628.380421314 1.0 0.7760356158605963 0.7651612774114714 21.740304029463964 DAMMAK(ub)AEYLCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DAMMAKAEYLCR 12 1 Q15008;Q15008-4;Q15008-3;Q15008-2;C9J7B7;C9J0E9 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 1 85258600.0 7680600.0 19528000.0 58050000.0 True False 9942688.107260443 18441249.633508377 47485495.64329924 1.0 1.8547549148244964 4.775921273103592 23.245204521184395 -6.948490482715103 0.5751767316117151 0.96441397457829 5.8095557187163855 0.9990774408886168 0.049102932562328325 0.08409760771857602 0.038514978673097715 0.0517195595399856 0.24370882690077014 1.1259251425516114e-07 6.948490482715103 4.845141744138095 DANGNSFATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DANGNSFATR 10 0 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 9781600.0 3660000.0 1365000.0 4756600.0 False True 3543815.3033827143 1910051.6183809624 3510703.765058733 1.0 0.5389817061170601 0.9906565282077836 21.756871984775398 -10.864449116903353 10.48251890180546 1.0089225157264592 0.7648191171624219 0.2655082079236598 0.18439547396410735 0.038143134275831506 0.000493233232171491 0.17711156734482444 0.05951338331491756 1.3663151474298425e-11 10.864449116903353 -0.2441033985640373 DANIMSPGSSLPSLHVRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DANIMSPGSSLPSLHVRK 18 1 P25054-2;P25054-3;P25054;A0A2Q2SV78;E9PFT7 P25054-2 APC Adenomatous polyposis coli protein 0 7451400.0 1269900.0 1880100.0 4301400.0 False True 1643910.583471349 1775470.7822592768 3518589.3360910853 1.0 1.0800288045534203 2.140377567654007 20.648700398580548 -6.922014435333712 0.809645665698283 0.9782593784896639 2.319550760614738 0.9947224755348011 0.03775762487708905 0.0970008614681697 0.09957813291307505 0.03288404135646416 0.1004830164383071 1.196700754007381e-07 6.922014435333712 1.3412913821250738 up DANLYISGLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DANLYISGLPR 11 0 Q15717;Q15717-2;M0QZR9;M0R055 Q15717 ELAVL1 ELAV-like protein 1 0 50379000.0 13254000.0 16119000.0 21006000.0 False True 17376122.351918582 13714108.031369872 18832500.62378022 1.0 0.7892501994183778 1.0838149181023022 24.05060283106939 -6.714627525430759 1.7783915893093047 0.8710517732776688 1.0832302014871582 0.4871111703013117 0.08874792370650296 0.3658915977089304 2.258416207817361 0.039668145338650214 0.10022627756554842 1.929178772514308e-07 6.714627525430759 0.2121784282094894 DANLYISGLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DANLYISGLPR 11 0 Q15717;Q15717-2;M0QZR9;M0R055 Q15717 ELAVL1 ELAV-like protein 1 0 42251600.0 13992000.0 7282600.0 20977000.0 False True 13547831.618833581 10190580.158257293 15482494.403489238 1.0 0.7521927083955494 1.1428023937030762 23.691558625525644 -6.735289846766155 1.7040387265075927 0.8517563740053942 1.142800006912247 0.5835817334610982 0.10413603484028765 0.32640168390211655 1.8590810871965684 0.04838370512776367 0.1193441981516025 1.8395438859122996e-07 6.735289846766155 0.29104363290685287 DANLYISGLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DANLYISGLPR 11 0 Q15717;Q15717-2;M0QZR9;M0R055 Q15717 ELAVL1 ELAV-like protein 1 0 45296000.0 13254000.0 12035000.0 20007000.0 False True 18154361.975882303 11503253.905577082 15281758.657099066 1.0 0.6336358127517188 0.8417678725036203 24.113812892592282 -10.301043100796157 5.311322669870637 1.0000508638279935 0.7377018426276526 0.6792441142650605 0.0849695575845007 5.118727205202063e-05 6.735981362900512e-06 0.08228734235330536 0.027423806788272654 4.9998491238664564e-11 10.301043100796157 -0.26234902120034087 DANLYISGLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DANLYISGLPR 11 0 Q15717;Q15717-2;M0QZR9;M0R055 Q15717 ELAVL1 ELAV-like protein 1 0 29156400.0 13992000.0 6580000.0 8584400.0 False True 11634967.950699624 6544552.233972265 10379358.350218955 1.0 0.5624899236253361 0.8920831062190278 23.47196390095992 -9.909310723609046 7.093419265423275 1.0000000050002333 0.7272865149221813 0.47721761631377235 0.13455585334242165 1.0579342392332522e-08 1.6421165614113417e-09 0.13028314672384955 0.043427714927493415 1.232222902268814e-10 9.909310723609046 -0.272713490078052 DANNGNLQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DANNGNLQLR 10 0 P05455 P05455 SSB Lupus La protein 0 8427740.0 2843600.0 660340.0 4923800.0 False True 2753331.474507946 924017.2056276079 3634109.0691662477 1.0 0.33559969592572975 1.3198952261335362 21.39274687625776 -6.724903561769463 1.7418483757177756 0.5979053989325489 1.3187791543213665 0.5354199624484871 0.2794285888122202 0.3459015805676853 2.053551949820013 0.12725466932017063 0.31760782837500756 1.8840674138369802e-07 6.724903561769463 0.7208737553888176 DANSSFFDNSSSPHLLDQLK(ub)AQNQELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DANSSFFDNSSSPHLLDQLKAQNQELR 27 1 P49454 P49454 CENPF Centromere protein F 1 44701100.0 4400100.0 19640000.0 20661000.0 True False 6675273.39039872 16135088.551979594 16577344.293961985 1.0 2.4171427308411455 2.48339555917002 22.670395493898972 -10.702380365099627 0.5686199416547547 1.5013328117837452e-20 2.476933337190006 0.9998288830194416 0.00895011116997483 2.24206236420206 0.27661476113575234 3.132376985340087 0.012018785852469216 1.9843562112426425e-11 10.702380365099627 2.476933337190006 DANSSFFDNSSSPHLLDQLK(ub)AQNQELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DANSSFFDNSSSPHLLDQLKAQNQELR 27 1 P49454 P49454 CENPF Centromere protein F 1 12168900.0 3162200.0 4254200.0 4752500.0 True False 2629509.4092125734 4231281.780207417 5746225.776922746 1.0 1.609152553469853 2.1852843563862723 21.32636222856911 -6.971800121364228 0.21080429947135507 0.7014394587618039 3.1090953947262365 0.9999932261358071 0.0012595539604243846 0.07572284938447711 0.0068997309696952535 0.017142834758500175 0.05959066907232831 1.0670871218140003e-07 6.971800121364228 2.4076559359644327 DAQDVQASQAEADQQQTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAQDVQASQAEADQQQTR 18 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 3535880.0 717690.0 373590.0 2444600.0 False True 694907.3237936441 522766.4352461131 1804285.9235719992 1.0 0.7522822358414962 2.596441081843872 19.406461060303755 -6.873019583411144 1.1179339435747537 0.8569689858947894 2.7108587784124287 0.9676081734140287 0.14708438856985234 0.13399584897337652 0.31114900378518245 0.10190428994191726 0.24262229783282993 1.3396162794563175e-07 6.873019583411144 1.8538897925176392 up DAQELYAAGENR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAQELYAAGENR 12 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 9282060.0 2902500.0 430060.0 5949500.0 False True 2810361.726248176 601785.200733272 4391147.46882583 1.0 0.21413086974275491 1.5624847961077233 21.42232440335692 -6.748692274702304 1.6545337866906658 0.5371858352137338 1.5649280714227929 0.6434137658399202 0.33020848230799227 0.30231727579721873 1.6278456068759568 0.15768114859876 0.3833569253506557 1.7836421438508932e-07 6.748692274702304 1.0277422362090591 DAQELYAAGENR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAQELYAAGENR 12 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 9990900.0 1395900.0 3321600.0 5273400.0 False True 1912001.9527790952 3174840.7289376697 4027931.5290821367 1.0 1.6604798568971324 2.1066565979326213 20.866652566106893 -8.125124278298332 0.12285039117034799 5.282047621445911e-19 3.257156986621672 0.9999714019077197 0.0024310958111276597 0.09240190260102704 0.023209422276076752 0.2729493932617761 0.2983771071912837 7.49679649288677e-09 8.125124278298332 3.257156986621672 DAQVVQVVLDGLSNILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DAQVVQVVLDGLSNILK 17 0 O00629;H7C4F6 O00629 KPNA4 Importin subunit alpha-3 0 550750000.0 195960000.0 245140000.0 109650000.0 False True 297285646.5949713 201392851.71243802 87977629.43869773 1.0 0.6774388673625411 0.2959363509351006 28.1472745685061 -7.226849678964835 0.32567378687435955 1.058529457758477 1.1873375501195477e-16 0.9998634731355625 0.0033624157072413238 0.09338731849056404 0.019585294330786693 0.010063954165610312 0.04332259560719294 5.931305875503161e-08 7.226849678964835 -1.0585294577584767 down DASLMVTNDGATILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DASLMVTNDGATILK 15 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 45023000.0 10867000.0 14711000.0 19445000.0 False True 14246742.236177709 12516176.143028872 17433017.92961088 1.0 0.8785289952987081 1.2236494238901892 23.76412872404798 -6.81160014931645 1.407864342165772 0.9339230732845964 1.229906437325172 0.8639397590007702 0.052724736638033065 0.20463283449136616 0.7991032816157755 0.02944505085062882 0.0680622445708463 1.5431205351115158e-07 6.81160014931645 0.29598336404057557 DASLMVTNDGATILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DASLMVTNDGATILK 15 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 35277000.0 11719000.0 0.0 23558000.0 False True 11346986.759656288 0.0 17387453.075148962 1.0 0.0 1.5323410032493636 23.43580589881524 -6.730609089180823 1.7210270598298285 0.39861194387721954 1.5315278135266217 0.562077922867612 0.42035629172533384 0.3350984852767451 1.944758360416498 0.19353521354577227 0.4799104130182173 1.859477427773121e-07 6.730609089180823 1.1329158696494022 DASLMVTNDGATILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DASLMVTNDGATILK 15 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 39777000.0 10867000.0 11049000.0 17861000.0 False True 14884823.5696328 10560818.645843038 13642599.658841744 1.0 0.7095024402834469 0.9165442636938356 23.82733878557087 -9.950980218306613 5.460675877989557 1.0000003494864798 0.8130233527033233 0.5209397189565466 0.0845244704635067 3.5969308147676977e-07 6.900839376956605e-08 0.08184062027018275 0.027280155537434687 1.1194888739407455e-10 9.950980218306613 -0.1869769967831565 DASLMVTNDGATILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DASLMVTNDGATILK 15 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 20882300.0 11719000.0 0.0 9163300.0 False True 9744867.739726195 0.0 11079303.663687779 1.0 0.0 1.1369373048052347 23.216211174249516 -10.692024914915228 4.413583388498248 1.0188685463770377 0.5684686524114893 0.16113269482195347 0.4641527110515706 0.08674879034348054 0.006053232477043849 0.45239464723679407 0.14980464333327917 2.0322404205757244e-11 10.692024914915228 -0.45039989396554847 DASLMVTNDGATILK(ub)NIGVDNPAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DASLMVTNDGATILKNIGVDNPAAK 25 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 17620100.0 3989100.0 5339100.0 8291900.0 True False 3862468.204022947 7471030.47303869 6120002.63833211 1.0 1.934263294454373 1.5844797458676378 21.88109162607265 -10.21068362659242 4.706453918991845 0.9998543572220984 1.759371520163374 0.8627161797891394 0.14279853575582382 0.00021941916739106652 3.6798594027787337e-05 0.13829038923832235 0.04608802923525853 6.156251779933138e-11 10.21068362659242 0.7595171629412756 DASLMVTNDGATILK(ub)NIGVDNPAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DASLMVTNDGATILKNIGVDNPAAK 25 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 16728700.0 3989100.0 7865800.0 4873800.0 True False 3317113.397093761 7823425.374160934 5892889.04609492 1.0 2.3585040478312593 1.7765111832649092 21.661496901506926 -10.052641627176977 5.318539800253029 0.9999902319593743 2.0675076155495904 0.8177130602000462 0.23759759202665426 2.7519698973229785e-05 4.901878375930943e-06 0.2300549807019734 0.07668429308408968 8.858462944325637e-11 10.052641627176977 1.067517383590216 DASLVFK(ub)VAETANEEEVKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DASLVFKVAETANEEEVKK 19 2 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 17108600.0 4389100.0 6739000.0 5980500.0 True False 5754152.604104859 5733567.468416264 5361695.229006832 1.0 0.9964225600005968 0.9317957999900701 22.456172052178548 -6.918314637767282 0.8371246093665354 1.0015144158151161 0.9217674910783289 0.9936998747172943 0.002487760098767389 0.09917387035066441 0.11082551471477467 0.002124542856992232 0.006265065316169021 1.2069391147556014e-07 6.918314637767282 -0.07974692473678724 DASLVFK(ub)VAETANEEEVKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DASLVFKVAETANEEEVKK 19 2 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 30661400.0 7088000.0 9026400.0 14547000.0 True False 6862995.319775049 12630688.592054171 10736704.299354456 1.0 1.84040466349439 1.5644341572575016 22.71040694015901 -10.159283045945127 4.7658802303128445 0.9999308423809949 1.7024194103802157 0.8962425787660571 0.11266448740433496 8.279715220989466e-05 1.4605303763955414e-05 0.10909759699663157 0.036362306950081906 6.929740217411142e-11 10.159283045945127 0.7024885679992208 DASLVFK(ub)VAETANEEEVKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DASLVFKVAETANEEEVKK 19 2 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 101860000.0 16587000.0 35428000.0 49845000.0 True False 25163691.672130976 29105596.5997726 39993113.90216039 1.0 1.1566505018024569 1.5893182297434179 24.58484025440891 -6.953292870019436 0.5214437842613403 0.992729015234547 1.772595815896359 0.9994349930509043 0.005924143922017136 0.08218985722127098 0.030694277713830164 0.006695977682076094 0.03574376601081913 1.1135433533123342e-07 6.953292870019436 0.779866800661812 DASLVFK(ub)VAETANEEEVKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DASLVFKVAETANEEEVKK 19 2 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 20009900.0 4389100.0 8327900.0 7292900.0 True False 6011868.88096763 7959945.841317429 5570467.2219902 1.0 1.3240384976653465 0.926578295748462 22.51938211370144 -6.6899681027755475 1.866840318060417 1.2031630787154912 0.9279647934355806 0.3701249040533371 0.13704713426440587 0.41674314656411154 2.815983112604509 0.05873275370793737 0.1529327813059156 2.0418879078117813e-07 6.6899681027755475 -0.27519828527991064 DASLVFK(ub)VAETANEEEVKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DASLVFKVAETANEEEVKK 19 2 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 26052900.0 7088000.0 7280900.0 11684000.0 True False 5893986.051640865 7241676.346554509 14127070.379287815 1.0 1.2286551551200993 2.3968618614825 22.490812215593287 -6.939326202155524 0.6658131055317338 0.9867225125980025 2.7057313816267476 0.9980741719950649 0.02684647485479293 0.08807558004093269 0.0560218812200384 0.02600133944726775 0.1008475240989509 1.1499363378505786e-07 6.939326202155524 1.719008869028745 up DASLVFK(ub)VAETANEEEVKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DASLVFKVAETANEEEVKK 19 2 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 72103000.0 16587000.0 30642000.0 24874000.0 True False 21472198.47865128 28936745.763517227 20347187.228792872 1.0 1.347637774133262 0.9476061451752623 24.35596657650136 -6.676940539179595 1.9124164512750537 1.2205578566638213 0.949153053725 0.3102097462724429 0.1474373675953891 0.44542717677804405 3.146843904239466 0.061917235117365896 0.16396589900157893 2.1040664953624055e-07 6.676940539179595 -0.2714048029388213 DASLVVTTSGDHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DASLVVTTSGDHK 13 0 C9JG97;C9JEH3;Q13685;H7C0R2 C9JG97 AAMP Angio-associated migratory cell protein 0 4137510.0 991010.0 1247600.0 1898900.0 False True 1299223.7069544904 1061462.943106711 1702420.0435350018 1.0 0.8169978252589661 1.3103363450207075 20.309218432078154 -6.806300931888227 1.43034371296253 0.8998208461107683 1.3182297556206306 0.8498579597516471 0.07890233571194497 0.21189604870105297 0.8551318132116046 0.043386744848024635 0.10052642843885436 1.5620648795539536e-07 6.806300931888227 0.4184089095098623 DASLVVTTSGDHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DASLVVTTSGDHK 13 0 C9JG97;C9JEH3;Q13685;H7C0R2 C9JG97 AAMP Angio-associated migratory cell protein 0 3080600.0 0.0 0.0 3080600.0 False True 0.0 0.0 2273698.4439809816 0.0 DASTLQSQK(ub)AEGTGDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DASTLQSQKAEGTGDAK 17 1 O00479 O00479 HMGN4 High mobility group nucleosome-binding domain-containing protein 4 1 4722900.0 1235900.0 2419900.0 1067100.0 True False 1874950.656392757 1988049.9382350016 856187.2172734559 1.0 1.0603212044309678 0.456645199890586 20.838421197618455 -6.88230741515029 1.066797874011722 1.0386655085796794 0.41191540380933706 0.9755015125538099 0.04249155818818633 0.12560798238049728 0.26007541959001323 0.03061510232985237 0.07449198527832056 1.3112713875830877e-07 6.88230741515029 -0.6267501047703423 down DATK(ub)AATAAADFTAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DATKAATAAADFTAK 15 1 Q9Y3F4;Q9Y3F4-2 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 1 6756600.0 1897500.0 0.0 4859100.0 True False 2878646.225831588 0.0 3898696.755180816 1.0 0.0 1.3543507778746082 21.456959067638714 -6.708879314493037 1.7990354989927888 0.3845288362818967 1.351089384521875 0.4598616483922805 0.42146806508231777 0.3773276890511353 2.3798465083148774 0.1864763010785885 0.47441149035466684 1.95488261999307e-07 6.708879314493037 0.9665605482399783 DATK(ub)AATAAADFTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DATKAATAAADFTAK 15 1 Q9Y3F4;Q9Y3F4-2 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 1 7655300.0 1897500.0 1821800.0 3936000.0 True False 2456351.155316864 1720415.2285090932 3219688.386770474 1.0 0.700394658469409 1.3107606295628123 21.228085389731163 -6.773247132931408 1.562180540247225 0.8288674660623296 1.3146103376379716 0.7427727572179137 0.12638552739146725 0.2612099128132844 1.2584949186325076 0.0637552748922218 0.1513067958138026 1.6855935745016065e-07 6.773247132931408 0.485742871575642 DATNVGDEGGFAPNILENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DATNVGDEGGFAPNILENK 19 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 202473500.0 4808500.0 122850000.0 74815000.0 False True 6303990.065580242 104521258.86554927 67073861.47615529 1.0 16.580175060274108 10.63990596088948 22.58783383058588 -9.520287376034723 11.481502333621165 0.9999999999918809 13.610040510581793 0.8573142560114192 2.4251047047190855 0.0 0.0 2.3480975335465684 0.7826991778488559 3.01795405588058e-10 9.520287376034723 12.610040510589913 DATNVGDEGGFAPNILENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DATNVGDEGGFAPNILENK 19 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 198427000.0 73525000.0 24917000.0 99985000.0 False True 71190989.12055027 34866488.04043845 73795929.01429543 1.0 0.48975984841842507 1.0365908653036708 26.08519131026578 -11.864946588413792 14.357571093866342 0.9067253082246612 0.7868578211749377 0.0 0.2556451884546944 0.0 0.0 0.0 0.07425322343189336 1.3647509697871384e-12 11.864946588413792 -0.1198674870497235 DATNVGDEGGFAPNILENK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DATNVGDEGGFAPNILENK 19 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 191780500.0 4808500.0 96921000.0 90051000.0 False True 6586332.394826475 92638709.745113 68782808.45856087 1.0 14.065295249580808 10.443264071000936 22.65104389210877 -9.360344932190275 10.62063512326644 0.9999074488098438 12.254279660290877 0.927915998079295 1.4786880376275249 0.0 0.0 1.4317335355556315 0.4772445118518771 4.3616927341702413e-10 9.360344932190275 11.254372211481034 DATNVGDEGGFAPNILENK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DATNVGDEGGFAPNILENK 19 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 80967400.0 73525000.0 4620000.0 2822400.0 False True 61139295.20977632 4595111.1430017995 3412550.7906968505 1.0 0.07515806532010906 0.05581599818885671 25.865596585700057 DATNVGDEGGFAPNILENK(ub)EGLELLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DATNVGDEGGFAPNILENKEGLELLK 26 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 31950700.0 6585600.0 5277100.0 20088000.0 True False 6376543.732775191 7384273.549712945 14826350.172917577 1.0 1.1580369960858359 2.3251389458384333 22.6043432236106 -6.9316162479571135 0.7334068720955954 0.9832734920712469 2.5749059853785057 0.9968464496374094 0.03318619333046856 0.09180715751942174 0.07363287860769942 0.030530285459419153 0.1046797345915257 1.1705332427986054e-07 6.9316162479571135 1.5916324933072588 up DATNVGDEGGFAPNILENK(ub)EGLELLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DATNVGDEGGFAPNILENKEGLELLK 26 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 318074000.0 10500000.0 29538000.0 278036000.0 True False 15929267.652822996 24266713.118552636 223082062.73249197 1.0 1.523404192047214 14.004539793953253 23.92517660477673 -6.915713233566008 0.8559276196579209 0.6798216732807394 15.831276137772972 0.9929047113814434 0.5063135110623875 0.10075987101981632 0.11917360680785913 0.4266129663297666 1.2299063060118827 1.214190320695273e-07 6.915713233566008 15.151454464492232 up DATNVGDEGGFAPNILENK(ub)EGLELLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DATNVGDEGGFAPNILENKEGLELLK 26 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 30394100.0 6585600.0 8169500.0 15639000.0 True False 5476218.191547133 8125489.281981209 18909042.59343395 1.0 1.4837774898237954 3.4529381284736202 22.384748499044875 -6.944473929180924 0.6165371547931563 0.9783872332292174 4.062033191490289 0.9986931300741931 0.03835026246805726 0.0857835601097199 0.04575121273339009 0.03874460436144383 0.1664358541793695 1.1363865132196484e-07 6.944473929180924 3.0836459582610716 up DATNVGDEGGFAPNILENK(ub)EGLELLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DATNVGDEGGFAPNILENKEGLELLK 26 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 351175600.0 10500000.0 19906000.0 320769600.0 True False 13592456.985943105 18798213.601219688 262392824.17403707 1.0 1.3829886399979205 19.304296820317 23.69630292686918 -6.91151330306333 0.8853573463501982 0.47132335720061824 21.69695969890361 0.9914804163049871 0.7882452885715364 0.10342604535945449 0.1333988630239996 0.650214564162483 1.8142965619469766 1.2259893482893344e-07 6.91151330306333 21.22563634170299 up DATSK(ub)VALVYGQMNEPPGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DATSKVALVYGQMNEPPGAR 20 1 P06576;H0YH81;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 1 17372700.0 4593900.0 3302100.0 9476700.0 True False 4448069.159073728 4620645.750224016 6994467.975093983 1.0 1.038798090807164 1.572472847196135 22.084747788742842 -6.921516506430348 0.8133807527503842 0.9888570917965922 1.6616140230759855 0.9945925418928847 0.019207611171382106 0.09728685850957602 0.10104351521710786 0.016683839188366405 0.05072564885414044 1.1980735865902065e-07 6.921516506430348 0.6727569312793933 DAVAITK(ub)QFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAVAITKQFLK 11 1 A0A2R8YE10;A0A2R8YD95;Q9NRW7;A0A087WU65;A0A1B0GXI6;Q9NRW7-2;A0A2R8YF01 A0A2R8YE10 VPS45 Vacuolar protein sorting-associated protein 45 1 10464500.0 3768900.0 3787000.0 2908600.0 True False 4941064.398079525 3221994.3616103786 2607645.9732613126 1.0 0.6520850776328055 0.5277498456152167 22.236390428223245 -13.999999999999998 0.14328445282688032 2.667381898941972 0.37980132382991866 0.9995901698725359 0.004046171989510481 11.938808844951387 0.1188259614619653 5.556407429299075 0.13257782352194203 1.0000000000000041e-14 13.999999999999998 -2.2875805751120537 DAVAITK(ub)QFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAVAITKQFLK 11 1 A0A2R8YE10;A0A2R8YD95;Q9NRW7;A0A087WU65;A0A1B0GXI6;Q9NRW7-2;A0A2R8YF01 A0A2R8YE10 VPS45 Vacuolar protein sorting-associated protein 45 1 6409600.0 3768900.0 2640700.0 0.0 True False 5162364.1806928385 2524025.142372862 0.0 1.0 0.4889281449403893 0.0 22.299600489746137 -7.963433331177496 0.5862033272368106 1.0123616299716576 9.50884996445377e-19 0.9892756566766672 0.04228099651454945 0.11185683631013975 0.1631229059836229 0.045487787307998094 0.0766327285579513 1.0878441204575925e-08 7.963433331177496 -1.0123616299716576 DAVAITK(ub)QFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAVAITKQFLK 11 1 A0A2R8YE10;A0A2R8YD95;Q9NRW7;A0A087WU65;A0A1B0GXI6;Q9NRW7-2;A0A2R8YF01 A0A2R8YE10 VPS45 Vacuolar protein sorting-associated protein 45 1 17472000.0 5877200.0 7901700.0 3693100.0 True False 4887152.204106049 7859131.973735349 4465310.135034908 1.0 1.608120976288057 0.9136834599264739 22.220562605500664 -6.6753891532718175 1.9187489515961216 1.3863535224903087 0.9164420408111275 0.30299403962592253 0.25800090421971417 0.4488176435591279 3.1906605039635156 0.10806789346651281 0.28666637230902603 2.111596078198991e-07 6.6753891532718175 -0.4699114816791813 DAVITVPVFFNQAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAVITVPVFFNQAER 15 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1;J3QL06 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 31284200.0 7939900.0 14070000.0 9274300.0 False True 10409285.790100966 11970810.84443043 8314684.401367465 1.0 1.1500126988361148 0.7987756863467591 23.311367748946125 -6.7906281415901 1.4936399849838757 1.0837717391830244 0.7949649902534182 0.8034291844502215 0.06379953247465331 0.23440342906889058 1.03305257878827 0.033618680276633284 0.07867988947909998 1.6194660887341394e-07 6.7906281415901 -0.2888067489296062 DAVITVPVFFNQAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAVITVPVFFNQAER 15 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1;J3QL06 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 31044200.0 10937000.0 7303200.0 12804000.0 False True 10589810.921611117 10219405.845684862 9450248.288233599 1.0 0.9650225033602486 0.8923906534485937 23.336173494817594 -6.959304595549614 0.445138166414803 1.0024621821135618 0.8520949292948351 0.9997434810581495 0.0007178052113976379 0.07995065610429272 0.022057436063643635 0.0009640656502538363 0.00601246790824401 1.0982353140433785e-07 6.959304595549614 -0.15036725281872665 DAVITVPVFFNQAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAVITVPVFFNQAER 15 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1;J3QL06 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 45962900.0 7939900.0 18083000.0 19940000.0 False True 10875495.597729571 17284033.267515585 15230582.677190747 1.0 1.589263966151933 1.4004495280537255 23.374577810469017 -10.033927925559064 4.380319024689644 0.9999717209564175 1.4948567471714516 0.9015608771306066 0.07708317181867817 53726932.618076056 93818137.22593549 21649.11873394015 0.028209547041684328 9.2485164730088e-11 10.033927925559064 0.49488502621503405 DAVITVPVFFNQAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAVITVPVFFNQAER 15 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1;J3QL06 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 23347400.0 10937000.0 5557600.0 6852800.0 False True 9094600.091252265 5527660.105702768 8285688.7962327665 1.0 0.6077958404151937 0.9110558697575324 23.11657877025187 -9.804058862263233 6.030854849770271 1.0000000147469272 0.7594258550859995 0.45625153348482583 0.12380538854632535 2.4505396219361817e-08 4.8870910092097754e-09 0.11987406004027194 0.03995801733403171 1.5701499790530556e-10 9.804058862263233 -0.24057415966092777 DAVLLLFANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAVLLLFANK 10 0 P18085;C9JPM4;C9JAK5;U3KQF2 P18085 ARF4 ADP-ribosylation factor 4 0 25363100.0 5522300.0 12663000.0 7177800.0 False True 7239788.778029272 10773729.75998739 6435110.110319411 1.0 1.4881276360827869 0.8888532949812245 22.787516176393027 -6.690088685410224 1.8658701845996917 1.3059926026370434 0.8909081092497757 0.3709691334334503 0.20643879248967192 0.41646436900184985 2.8111309068965467 0.08850327307712864 0.23046250293339599 2.0413210527033853e-07 6.690088685410224 -0.4150844933872677 DAVLLLFANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAVLLLFANK 10 0 P18085;C9JPM4;C9JAK5;U3KQF2 P18085 ARF4 ADP-ribosylation factor 4 0 23358600.0 10133000.0 5099300.0 8126300.0 False True 9811333.461523779 7135477.082498208 5997778.246225619 1.0 0.7272688376641936 0.6113112218381491 23.22601779624687 -13.999999999999998 0.11690049282139975 2.303445955370001 0.4182634236566463 0.9997082757135228 0.0027827803294876627 11.976676060182616 0.10481194223483402 3.642513640005844 0.1712991685489873 1.0000000000000041e-14 13.999999999999998 -1.8851825317133546 DAVLLLFANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAVLLLFANK 10 0 P18085;C9JPM4;C9JAK5;U3KQF2 P18085 ARF4 ADP-ribosylation factor 4 0 24811300.0 5522300.0 7033000.0 12256000.0 False True 7564043.544546163 6722258.8049791055 9361385.220243236 1.0 0.8887123355901353 1.2376165162339652 22.850726237915918 -6.820907102849019 1.3679990036511165 0.9400711232709058 1.2453792208237315 0.8864431048086077 0.049037117544065055 0.19230740567628699 0.7069208979162811 0.02816717752464379 0.06490389383909706 1.5104032002870397e-07 6.820907102849019 0.30530809755282573 DAVLLLFANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAVLLLFANK 10 0 P18085;C9JPM4;C9JAK5;U3KQF2 P18085 ARF4 ADP-ribosylation factor 4 0 19764100.0 10133000.0 4051100.0 5580000.0 False True 8426038.468013102 4029275.9202196132 6746752.200995036 1.0 0.47819339248396936 0.800702753329104 23.006423071681148 -10.471223485875212 6.012896074261529 1.0002385006654917 0.6394480729065412 0.6249681478545555 0.13166389522361951 0.00042123476360855056 3.704377572509259e-05 0.12756594644952865 0.04249433945815637 3.3789091440235454e-11 10.471223485875212 -0.36079042775895054 DAVLLVFANK(ub)QDLPNAMNAAEITDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAVLLVFANKQDLPNAMNAAEITDK 25 1 P84077;P61204;P61204-2 P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 1 14769200.0 4963800.0 6178300.0 3627100.0 True False 6507589.869507581 5256521.722824781 3251802.4855999826 1.0 0.8077524595480591 0.49969382687081376 22.633691899641253 -6.964136829632166 0.3725756873788167 1.0230088861161608 0.2736709151719863 0.9998942222859708 0.0021193367284068304 0.07825517642724616 0.015900701375926373 0.004045244761637379 0.026127549267789495 1.0860833862428585e-07 6.964136829632166 -0.7493379709441745 down DAVLLVFANK(ub)QDLPNAMNAAEITDK ddPTM_RPMI8226_Bortezomib_2h_R1 2 DAVLLVFANKQDLPNAMNAAEITDK 25 1 P84077;P61204;P61204-2 P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 1 336583300.0 60945500.0 75444300.0 200193500.0 True False 59010818.46238005 105569602.42682691 147756816.6737343 1.0 1.7889872599230008 2.5038937015918643 25.814476132436074 -6.9722987060458115 0.19563830165037102 0.5497681186055288 3.762759193541778 0.9999951999178639 0.0013456664235941159 0.07556359397267184 0.006283375950923102 0.024065736821467325 0.07675501866768838 1.065862772816304e-07 6.9722987060458115 3.2129910749362494 DAVLLVFANK(ub)QDLPNAMNAAEITDK ddPTM_RPMI8226_Bortezomib_8h_R1 2 DAVLLVFANKQDLPNAMNAAEITDK 25 1 P84077;P61204;P61204-2 P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 1 627171700.0 78276700.0 317103000.0 231792000.0 True False 118751476.69330767 260513492.11295286 185978209.6019572 1.0 2.1937705480982395 1.566112816283304 26.823370212793986 -10.238231800057628 5.7921665383699805 0.9999659461975932 1.8799416821907828 0.7238026912570537 0.25624019600991216 0.00011268684902157432 1.4820115655081588e-05 0.2481130524588669 0.08270116764793713 5.77787577121636e-11 10.238231800057628 0.8799757359931897 DAVLLVFANK(ub)QDLPNAMNAAEITDK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DAVLLVFANKQDLPNAMNAAEITDK 25 1 P84077;P61204;P61204-2 P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 1 265026300.0 60945500.0 83096000.0 120984800.0 True False 50678883.59343651 82648345.35473533 146282162.30948833 1.0 1.630824112420646 2.8864519487645843 25.59488140787035 -6.9601382470794 0.43348056955732245 0.9519271977284527 3.6137779146332103 0.9997752935967683 0.01175374382971866 0.07965176712935466 0.020949068151994526 0.016430737904710474 0.10417451126983104 1.0961292145409894e-07 6.9601382470794 2.6618507169047576 DAVLLVFANK(ub)QDLPNAMNAAEITDK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DAVLLVFANKQDLPNAMNAAEITDK 25 1 P84077;P61204;P61204-2 P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 1 472521700.0 78276700.0 206270000.0 187975000.0 True False 101330731.21443556 194790893.1740974 153765478.7863769 1.0 1.9223279141436562 1.5174614546201113 26.594496534886435 -10.374242342542185 7.5004926516279244 0.999985419319636 1.7198946843818836 0.8082652478675495 0.165286039966644 4.030112984453272e-05 3.3620874448966582e-06 0.1600407507562454 0.05334584001261549 4.224328249171357e-11 10.374242342542185 0.7199092650622476 DAVNQNTK(ub)LLQSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAVNQNTKLLQSAK 14 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 79611300.0 23831000.0 50422000.0 5358300.0 True False 31242671.77973226 42899234.143416606 4803874.516442995 1.0 1.3730974881362799 0.15376004172470817 24.897014497926705 -6.824601209954586 1.352019029695737 1.2002148004772468 0.12445962454250405 0.8945986183905731 0.1656171548394025 0.18757620911975048 0.6724745651878697 0.0962316416635873 0.22155494179095964 1.4976102025045002e-07 6.824601209954586 -1.0757551759347428 down DAVNQNTK(ub)LLQSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAVNQNTKLLQSAK 14 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 84434000.0 29570000.0 42998000.0 11866000.0 True False 28631316.53579966 60167325.6316078 8757938.62763042 1.0 2.1014515890799697 0.30588668937664043 24.771090674611678 -6.740702761911893 1.6839313840368249 1.6548209516653098 0.3046330637791631 0.6081617697490929 0.462777699217969 0.31655319988847314 1.7627282280524734 0.2173770308626464 0.5330523491907717 1.816758656037897e-07 6.740702761911893 -1.3501878878861469 DAVNQNTK(ub)LLQSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAVNQNTKLLQSAK 14 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 54933800.0 23831000.0 25901000.0 5201800.0 True False 32641964.70855974 24756608.17684684 3973241.9744338477 1.0 0.7584288629034295 0.12172190031784269 24.960224559449596 -7.198292176152267 0.6213621379847734 1.0005781529375686 9.899800968611204e-22 0.9976362065197545 0.018011044847981633 0.08736317052957586 0.058780741091495635 0.017294604043839534 0.05385848385106833 6.33443412197657e-08 7.198292176152267 -1.0005781529375686 down DAVNQNTK(ub)LLQSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAVNQNTKLLQSAK 14 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 104233000.0 29570000.0 69741000.0 4922000.0 True False 24588765.173112333 69365291.39049532 5951167.4432433 1.0 2.8210156509341853 0.24202790995583892 24.551495950045954 -6.7169797485073905 1.7700536863071306 2.1114287238269522 0.24667700298038214 0.4982929287693182 0.7665865413337388 0.36121545034732583 2.210044986329922 0.3440900819166269 0.8669206440737308 1.9187582117858472e-07 6.7169797485073905 -1.86475172084657 DAVNQNTK(ub)LLQSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DAVNQNTKLLQSAK 14 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 36521000.0 22102000.0 9566000.0 4853000.0 True False 28611474.69555379 9033643.690810185 3969803.795985037 1.0 0.3157349904866668 0.13874866074631037 24.77009052332431 -13.999999999995923 0.18985673887507892 4.6662580875334045 0.011593752832249369 0.9994894869381112 0.00839111861994901 12.348381627411563 0.13817725954297788 16.747354801400427 0.12185455468024749 1.000000000009387e-14 13.999999999995923 -4.654664334701155 DAVSGMGVIVHIIEKDK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAVSGMGVIVHIIEKDK 17 1 P49720 P49720 PSMB3 Proteasome subunit beta type-3 1 4216500.0 553400.0 2304000.0 1359100.0 True False 725512.7591332238 1960252.1809216607 1218473.369407772 1.0 2.7018851925686196 1.6794651149395257 19.468641460715553 -10.071179717395632 4.77305921933557 0.999956098630514 2.1906751537724602 0.6439106271484842 0.41740124889123 144859133.2665586 8.036388570113898 69893.66320308074 0.14288754970832643 8.488291444588665e-11 10.071179717395632 1.1907190551419462 DAVTYTEHAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAVTYTEHAK 10 0 P62805 P62805 HIST1H4A Histone H4 0 91489600.0 2730600.0 46340000.0 42419000.0 False True 3579843.043168015 39426252.6319052 38029888.79178013 1.0 11.013402586783407 10.623339719979798 21.771464903794943 -10.496079976178887 7.054159056624916 0.9972627944898192 10.818371153381602 0.9988176724538437 0.1592424985460068 0.0068434109231653205 0.0004888620653516484 0.153923061907687 0.05139529540642864 3.190950181270252e-11 10.496079976178887 9.821108358891783 DAVTYTEHAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAVTYTEHAK 10 0 P62805 P62805 HIST1H4A Histone H4 0 133272300.0 52002000.0 6591300.0 74679000.0 False True 50351224.97445563 9223240.46317541 55118329.57802229 1.0 0.18317807496946853 1.0946770332992914 25.585523541610918 -6.670450387172472 1.935895173462724 0.47885446318219876 1.0910016798578688 0.28120346009480035 0.346926303764905 0.45995131824996305 3.323706811149734 0.14425507411240623 0.3851705093003877 2.1357460549509703e-07 6.670450387172472 0.6121472166756701 DAVTYTEHAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DAVTYTEHAK 10 0 P62805 P62805 HIST1H4A Histone H4 0 1016525000.0 5782000.0 1008000000.0 2743000.0 False True 8771716.72082119 828114524.4600538 2200844.8477003924 1.0 94.40734930419953 0.2509024080173845 23.064427790812932 -13.968709861681422 4.3217839012513517e-10 8.995143196860054 76.39725126503359 0.0 45.512705808429686 849815387.6546293 0.2581878561270961 888196008.5970492 888195957.493811 1.0747071502018228e-14 13.968709861681422 67.40210806817353 DAVTYTEHAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAVTYTEHAK 10 0 P62805 P62805 HIST1H4A Histone H4 0 272790600.0 2730600.0 147560000.0 122500000.0 False True 3740176.611690373 141040311.2843335 93568022.96669336 1.0 37.70953244386776 25.017006596489377 21.834674965317834 -9.669959830419161 12.125591403501486 0.9999999682847213 31.36326952017857 0.8841287197643948 5.181701978860619 0.0 0.0 5.017161367284298 1.6723871224280988 2.1381598470525132e-10 9.669959830419161 30.363269551893847 DAVTYTEHAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAVTYTEHAKR 11 1 P62805 P62805 HIST1H4A Histone H4 1 25660750.0 5606800.0 983550.0 19070400.0 True False 7350569.096328445 836808.1738478724 17097177.94419395 1.0 0.11384263760827062 2.3259665639676617 22.809424520044196 -6.797989610534362 1.4641870095099572 0.5098175065026325 2.35498799499941 0.8262135677593753 0.3789520319988374 0.22362890802336452 0.9467119405748086 0.20363290212145094 0.47415001786674216 1.5922468173249716e-07 6.797989610534362 1.8451704884967775 DAVTYTEHAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAVTYTEHAKR 11 1 P62805 P62805 HIST1H4A Histone H4 1 62979700.0 19789400.0 12456900.0 30733400.0 True False 19161196.329169873 17431005.131875314 22683400.557763092 1.0 0.9097033834646003 1.183819640907871 24.191684302753274 -6.817941997757629 1.3806140502498532 0.9512241575002172 1.189549649163929 0.8795902269128171 0.03957822152849559 0.1961877616516674 0.7353242541063117 0.022529443528903403 0.05196095339360779 1.520750620169402e-07 6.817941997757629 0.23832549166371186 DAVTYTEHAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DAVTYTEHAKR 11 1 P62805 P62805 HIST1H4A Histone H4 1 72545300.0 20141100.0 2944000.0 49460200.0 True False 30555521.21164509 2418620.1984230145 39684369.79082421 1.0 0.07915493182624056 1.298762652940772 24.86492975472896 -6.704765029090604 1.814001379031602 0.43087064310310863 1.2954592836504684 0.44012434841641146 0.3883736518053078 0.3857107612331101 2.470733573037121 0.1705980371954761 0.4361506869682308 1.973490185465006e-07 6.704765029090604 0.8645886405473597 DAVTYTEHAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAVTYTEHAKR 11 1 P62805 P62805 HIST1H4A Histone H4 1 28321750.0 5606800.0 867850.0 21847100.0 True False 7679785.478072809 829505.5174038279 16687264.935148166 1.0 0.10801154794912146 2.1728816492066554 22.872634581567088 -6.789302174713447 1.4989994992866498 0.5010034726094786 2.1944534888422567 0.7990648747649938 0.3790359370779302 0.23640980709517143 1.0494240553452907 0.19903140333715522 0.4662433550091602 1.6244181199599269e-07 6.789302174713447 1.6934500162327781 DAVTYTEHAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAVTYTEHAKR 11 1 P62805 P62805 HIST1H4A Histone H4 1 50398200.0 19789400.0 17623200.0 12985600.0 True False 16455762.919066237 17528260.323668692 15700828.921369385 1.0 1.065174578041582 0.954123427676382 23.97208957818755 -6.747645236304913 1.6584836780805554 1.038431643459136 0.9539408633115758 0.6387916109477505 0.027384273489482715 0.3041786179347124 1.6453755670761505 0.01304740448753244 0.03175522024209406 1.7879475055895027e-07 6.747645236304913 -0.08449078014756028 DAVTYTEHAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DAVTYTEHAKR 11 1 P62805 P62805 HIST1H4A Histone H4 1 98649900.0 20141100.0 32046000.0 46462800.0 True False 26073050.99043608 30262611.929302044 38007047.148587145 1.0 1.1606854886450668 1.4577138349680903 24.636056076821408 -6.961555794018984 0.41292551446396103 0.9858267766417946 1.6436482118621272 0.9998236121801195 0.0025181465689482056 0.07915000277855244 0.01911210565959819 0.003828451935181673 0.02477666412911395 1.0925572568211116e-07 6.961555794018984 0.6578214352203325 DAVVYPILVEFTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DAVVYPILVEFTR 13 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 29261500.0 3159400.0 19437000.0 6665100.0 False True 4793040.783078951 15968315.48802585 5347740.0635828925 1.0 3.3315626156154114 1.1157301399275001 22.192509784952954 -6.634272261969159 2.0655021705885392 2.5313184633092556 1.1248789895924163 0.13287582097741535 0.9990531823531115 0.547973061801409 4.460819451563199 0.39490023266045315 1.1061591729467888 2.3212811142422889e-07 6.634272261969159 -1.4064394737168393 DAVVYPILVEFTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DAVVYPILVEFTR 13 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 15803300.0 3159400.0 5876600.0 6767300.0 False True 4089905.581084634 5549562.0440534325 5535720.838361741 1.0 1.3568924597476162 1.353508223750652 21.963636107045403 -10.111408988260223 4.420337843330371 0.9999581615018065 1.3552003417693415 0.9999319208924073 0.0013816086288106085 727812.4249321123 0.023910643740560723 310.6642150984257 0.0005056169747293625 7.737328069938728e-11 10.111408988260223 0.35524218026753496 DAYQVILDGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAYQVILDGVK 11 0 G3V1C3;Q9BZZ5-2;Q9BZZ5;Q9BZZ5-3;Q9BZZ5-6;E9PQK6 G3V1C3 API5 Apoptosis inhibitor 5 0 6994400.0 1830800.0 2261200.0 2902400.0 False True 2400196.5294924183 1923837.774088566 2602087.489786711 1.0 0.8015334371370871 1.0841143455602729 21.194721108706258 -6.717920037821635 1.7666109284851914 0.8789903279267601 1.083629184420152 0.5027849435831238 0.08353728455533299 0.3593665628487958 2.1906965172592536 0.037561473568337424 0.09453152716287339 1.9146084097345275e-07 6.717920037821635 0.20463885649339186 DAYQVILDGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAYQVILDGVK 11 0 G3V1C3;Q9BZZ5-2;Q9BZZ5;Q9BZZ5-3;Q9BZZ5-6;E9PQK6 G3V1C3 API5 Apoptosis inhibitor 5 0 6097600.0 1830800.0 0.0 4266800.0 False True 2507696.235509679 0.0 3259069.7175043863 1.0 0.0 1.2996269928371103 21.25793117022915 -6.701213873118459 1.8268669730608633 0.3797601841452349 1.2958041197991923 0.4231616994679488 0.4220218673179575 0.3930197897050887 2.5510095758740543 0.18424846435292164 0.47307234638191176 1.9896932512431185e-07 6.701213873118459 0.9160439356539574 DAYQVILDGVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAYQVILDGVK 11 0 G3V1C3;Q9BZZ5-2;Q9BZZ5;Q9BZZ5-3;Q9BZZ5-6;E9PQK6 G3V1C3 API5 Apoptosis inhibitor 5 0 3456390.0 1375200.0 831190.0 1250000.0 False True 1143539.7316896878 826712.214491703 1511369.2206530105 1.0 0.7229413999198416 1.3216586872935494 20.125075061628966 -6.7808842134959075 1.5324607420885064 0.8433002531817888 1.3265297039412187 0.7704761346307896 0.11720911539731516 0.24921372545922235 1.156066622805229 0.06023735336303715 0.14202807781361532 1.6562114643000114e-07 6.7808842134959075 0.4832294507594299 DAYSGGAVNLYHVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DAYSGGAVNLYHVR 14 0 P28074;P28074-3 P28074 PSMB5 Proteasome subunit beta type-5 0 24039800.0 3922100.0 8021700.0 12096000.0 False True 5141911.081670428 6824893.628341692 10844421.95302512 1.0 1.3273068164618127 2.1090255706059673 22.29387323139339 -6.956433548978582 0.4830846202367885 0.9817705343062956 2.4873240266879764 0.9996141913953788 0.009138522740808595 0.08100065794518668 0.026032627847522857 0.011091899093729953 0.06447922288909365 1.1055196110377584e-07 6.956433548978582 1.5055534923816807 up DAYSGGAVNLYHVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DAYSGGAVNLYHVR 14 0 P28074;P28074-3 P28074 PSMB5 Proteasome subunit beta type-5 0 20049400.0 3995600.0 1685800.0 14368000.0 False True 3868761.8650808623 2358948.731330861 10604589.769239334 1.0 0.6097425516474779 2.741081032915342 21.883440498249996 -6.859466210540527 1.1884993765444019 0.7885710090369683 2.8432100020848194 0.952984012752328 0.2009029910271598 0.14734896186432228 0.3958104331702218 0.1318753636779842 0.3076396972688023 1.3820819319849272e-07 6.859466210540527 2.0546389930478512 up DAYSGGAVNLYHVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DAYSGGAVNLYHVR 14 0 P28074;P28074-3 P28074 PSMB5 Proteasome subunit beta type-5 0 16742600.0 3922100.0 5404400.0 7416100.0 False True 5372206.3607671615 5165615.73803912 5664569.919373837 1.0 0.9615445482070909 1.054421505611137 22.357083292916283 -6.794264405987969 1.4792679525641856 0.9786256772580569 1.0555283979815402 0.8148360892645496 0.016396042894812553 0.2290553246366448 0.9900360143087752 0.008722334232834299 0.020359399632545985 1.6059632171526008e-07 6.794264405987969 0.07690272072348325 DAYSGGAVNLYHVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DAYSGGAVNLYHVR 14 0 P28074;P28074-3 P28074 PSMB5 Proteasome subunit beta type-5 0 9803100.0 3995600.0 2486200.0 3321300.0 False True 3322518.435092581 2472806.347127941 4015768.474043876 1.0 0.7442566220280541 1.2086519766539618 21.663845773684272 -6.757220336694363 1.623157372079507 0.8509357149802323 1.210106237629466 0.6794284461347797 0.10752705391331199 0.2876134965243597 1.49284505978658 0.05228718072916787 0.12599043271727048 1.7489591395928412e-07 6.757220336694363 0.35917052264923366 DCALTVVALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DCALTVVALR 10 0 A0A087X0W9;Q8N6M0;Q8N6M0-2 A0A087X0W9 OTUD6B OTU domain-containing protein 6B 0 5442400.0 1712500.0 1796400.0 1933500.0 False True 2245104.083873589 1528384.1223123576 1733439.9674416364 1.0 0.6807631473705936 0.7720978193807597 21.09835089972821 -10.173071882394451 7.5137623621937575 1.0000001673887773 0.726430483375677 0.9228512457831314 0.03728722370822795 1.0454924163431249e-07 1.1527489913423894e-08 0.03610322116893669 0.0120343997040231 6.713177303543463e-11 10.173071882394451 -0.27356968401310033 DCALTVVALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DCALTVVALR 10 0 A0A087X0W9;Q8N6M0;Q8N6M0-2 A0A087X0W9 OTUD6B OTU domain-containing protein 6B 0 4385500.0 1712500.0 1190500.0 1482500.0 False True 2345657.5285723875 1137899.7735429602 1132364.0330459033 1.0 0.4851090833517832 0.4827490881565656 21.1615609612511 DCDLQEDACYNCGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DCDLQEDACYNCGR 14 0 P62633-2;P62633;P62633-7;P62633-3 P62633-2 CNBP Cellular nucleic acid-binding protein 0 7162300.0 1625200.0 3097600.0 2439500.0 False True 2130652.9384591896 2635450.1543502314 2187083.941336374 1.0 1.2369213712750855 1.0264853096713127 21.022864181336686 -10.297524692273996 4.101330636141914 0.9998268138650981 1.1317033404793047 0.3430847054215148 0.08591016242202061 60970417.47285062 27.911482295296626 99717.8620849967 0.029409333670447024 5.040519598784625e-11 10.297524692273996 0.13187652661420657 DCDSLK(ub)GLCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DCDSLKGLCR 10 1 A0A0C4DGR2;M0QY25;Q86YD1-2;Q86YD1;M0QYQ4;M0QYH7 A0A0C4DGR2 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 13996700.0 0.0 3801700.0 10195000.0 True False 0.0 3123256.932182323 8179953.781372756 0.0 DCDSLK(ub)GLCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DCDSLKGLCR 10 1 A0A0C4DGR2;M0QY25;Q86YD1-2;Q86YD1;M0QYQ4;M0QYH7 A0A0C4DGR2 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 12317600.0 0.0 5144100.0 7173500.0 True False 0.0 4857826.312972674 5867996.606325698 0.0 DCEDVAK(ub)AALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DCEDVAKAALR 11 1 Q6NXE6-2;Q6NXE6;B4E1N1;H0YGL0;H0YH65 Q6NXE6-2 ARMC6 Armadillo repeat-containing protein 6 1 76031200.0 3380200.0 0.0 72651000.0 True False 5128010.525721178 0.0 58291498.005935565 1.0 0.0 11.367273470589792 22.28996779255036 -6.8854588747396495 1.0488509633236125 0.32109367374326286 12.262296266122561 0.9778298028420536 0.7651979334678727 0.12290593625978219 0.2439793304196378 0.5589261284313367 1.3725017665703982 1.3017905820358192e-07 6.8854588747396495 11.941202592379298 up DCEDVAK(ub)AALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DCEDVAKAALR 11 1 Q6NXE6-2;Q6NXE6;B4E1N1;H0YGL0;H0YH65 Q6NXE6-2 ARMC6 Armadillo repeat-containing protein 6 1 84763200.0 3380200.0 0.0 81383000.0 True False 4375735.533703329 0.0 66572129.06009691 1.0 0.0 15.213928846324661 22.06109411464281 -6.891195285084942 1.01530379853328 0.20580617363017098 16.553434699458332 0.9816517211455706 0.9411763460842338 0.11817795240491445 0.2162348555214257 0.705199409892728 1.7657778076440855 1.284708847188253e-07 6.891195285084942 16.34762852582816 up DCEECIQLEPTFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DCEECIQLEPTFIK 14 0 P31948;P31948-2;P31948-3;H0YGI8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 25186600.0 2018600.0 12545000.0 10623000.0 False True 2646404.1481502056 10673334.900026994 9523833.8630114 1.0 4.033146225034255 3.5987828501812196 21.335601970324113 -9.839649971554472 6.578130286962303 0.9999999433350029 3.81596453760799 0.9824679900557577 0.17732810522477588 1.705719218904353e-07 3.11150759015499e-08 0.17169720470391558 0.05723239986237176 1.4466052218402142e-10 9.839649971554472 2.815964594272987 DCEECIQLEPTFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DCEECIQLEPTFIK 14 0 P31948;P31948-2;P31948-3;H0YGI8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 23077600.0 2018600.0 10313000.0 10746000.0 False True 2764930.9706138517 9857337.559469575 8208016.120817047 1.0 3.565129713629384 2.968615205244982 21.398812031847005 -10.0973375886222 5.344998021742684 0.9999660610861526 3.26687245943881 0.9506302699786997 0.2435260282905266 9.849222516041992e-05 1.663303049541889e-05 0.23579655539625144 0.07859768766061317 7.992127642037142e-11 10.0973375886222 2.266906398352657 DCEVVMMIGLPGAGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 DCEVVMMIGLPGAGK 15 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 10248890.0 2392650.0 5097200.0 2759040.0 False True 3136787.3204555623 4336717.628729977 2473561.0073804874 1.0 1.3825347993628545 0.7885651001105318 21.58085628463075 -6.732789212379228 1.7129202644676818 1.2294861141756144 0.7887245466292988 0.5722237662806233 0.16077617195674362 0.3310266669719461 1.9040002492860717 0.07434106051689111 0.18390249733674954 1.8501663912514907e-07 6.732789212379228 -0.44076156754631557 DCEVVMMIGLPGAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DCEVVMMIGLPGAGK 15 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 3829900.0 2137900.0 0.0 1692000.0 False True 2070033.5347272928 0.0 1248814.4410880404 1.0 0.0 0.603282227141581 20.98122270902601 -10.102181093837569 6.683353190773911 1.0000006976503437 0.30164111357079 0.6411544001548216 0.24628893789778486 2.560401627309014e-06 3.440023364773423e-07 0.23846847676180005 0.0794894129027691 7.903489964161998e-11 10.102181093837569 -0.6983595840795538 DCEVVMMIGLPGAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DCEVVMMIGLPGAGK 15 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 6616000.0 1587900.0 1962500.0 3065600.0 False True 2174989.5413839966 1875790.2608803518 2341568.418013838 1.0 0.862436450929664 1.0765883575347417 21.05257703298452 -6.733241137759389 1.7115422140374132 0.9175154824113875 1.076535492732408 0.5741978552695322 0.05781498622510456 0.3301807939806881 1.8963278298253645 0.02675393745405726 0.06614257587371297 1.8482421156858178e-07 6.733241137759389 0.15902001032102053 DCEVVMMIGLPGAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DCEVVMMIGLPGAGK 15 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 5585000.0 2137900.0 1065700.0 2381400.0 False True 1777758.575028638 1059958.8625751117 2879339.7296504634 1.0 0.596233300440155 1.6196460926107923 20.761627984460286 -6.7996711534991 1.4572201725227387 0.7771294960540462 1.6336641843430189 0.8312049378532803 0.17292276021289624 0.2212303018692433 0.9274912840317112 0.09335489226001195 0.2171560678312683 1.5860937233742406e-07 6.7996711534991 0.8565346882889726 DCGATWVVLGHSER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DCGATWVVLGHSER 14 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3;U3KPS5 P60174 TPI1 Triosephosphate isomerase 0 256342000.0 73943000.0 82526000.0 99873000.0 False True 96939989.06503066 70213442.4838285 89539100.00946403 1.0 0.7242980235610189 0.9236549423313647 26.530588583977796 -10.465449897757216 5.410629048633086 1.0002255892410032 0.8239764829461909 0.5096797202331929 0.08138712128014018 0.00022175653213686458 2.1908645601909244e-05 0.0789031121719812 0.02626758044281168 3.424128877002657e-11 10.465449897757216 -0.17624910629481239 DCGATWVVLGHSER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DCGATWVVLGHSER 14 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3;U3KPS5 P60174 TPI1 Triosephosphate isomerase 0 96690600.0 46717000.0 8637600.0 41336000.0 False True 45233994.40659296 12086638.724488946 30508861.546581123 1.0 0.26720255159971656 0.6744675535913845 25.43090406358869 -10.732458479830477 6.5430244933076676 1.0093985390188025 0.47083505259847497 0.6923980200177011 0.1662652408288602 0.022743627219812424 0.000929976096161611 0.16062185559790887 0.05366187573194512 1.85157590329429e-11 10.732458479830477 -0.5385634864203275 DCGATWVVLGHSER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DCGATWVVLGHSER 14 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3;U3KPS5 P60174 TPI1 Triosephosphate isomerase 0 238751000.0 45253000.0 159244000.0 34254000.0 False True 68652109.43744752 130825664.02094921 27483681.885938484 1.0 1.9056321079274516 0.40033266437326714 26.032800714200658 -6.743787588605692 1.6727538741941672 1.5364674244719634 0.3986871035844638 0.6218550070696938 0.3804928102962422 0.31100583000799614 1.710058680667885 0.17984238880232342 0.4395085297853878 1.8038998040695833e-07 6.743787588605692 -1.1377803208874995 DCGATWVVLGHSER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DCGATWVVLGHSER 14 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3;U3KPS5 P60174 TPI1 Triosephosphate isomerase 0 240594000.0 73943000.0 80139000.0 86512000.0 False True 101281725.33443986 76598193.99576588 66079647.37056809 1.0 0.7562883999342714 0.6524340610546289 26.593798645500687 -13.999999999999998 0.11654397485357747 2.165191355808687 0.478685794419893 0.9997100538082125 0.0024804689748454223 11.978321905985796 0.10460240090856966 3.2483936130387177 0.15417638359893296 1.0000000000000041e-14 13.999999999999998 -1.686505561388794 DCGATWVVLGHSER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DCGATWVVLGHSER 14 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3;U3KPS5 P60174 TPI1 Triosephosphate isomerase 0 85949400.0 46717000.0 11419100.0 27813300.0 False True 38847255.41401048 11357583.041786125 33628932.435830735 1.0 0.29236513418371246 0.8656707424355717 25.211309339022968 -10.287648534605566 7.8858166665587435 1.0000010157586579 0.5790179383099565 0.4182466270337758 0.23405103448216671 4.179911997692378e-06 3.772659790931507e-07 0.2266194866565538 0.07553964655933748 5.156457770581483e-11 10.287648534605566 -0.42098307744870134 DCGATWVVLGHSER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DCGATWVVLGHSER 14 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3;U3KPS5 P60174 TPI1 Triosephosphate isomerase 0 174753000.0 45253000.0 94854000.0 34646000.0 False True 58580900.569988884 89575291.51663266 28340783.497980136 1.0 1.5290869659747475 0.4837887984347441 25.803927036293107 -6.7690985070830365 1.5777200286759832 1.3038314681355774 0.4780886140409024 0.7270993152246541 0.22293479575357103 0.26792640301149884 1.3160292199629273 0.11138133351488241 0.2653735907685548 1.7017724669832164e-07 6.7690985070830365 -0.825742854094675 down DCHHLGIQNNFDYKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DCHHLGIQNNFDYKR 15 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;A0A2R8YD90 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 4817800.0 1930300.0 1295700.0 1591800.0 False True 2643984.0743960747 1238451.6896930798 1215849.6241500615 1.0 0.4684036116881531 0.45985512391097877 21.334282056359264 DCHHLGIQNNFDYKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DCHHLGIQNNFDYKR 15 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;A0A2R8YD90 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 8940300.0 2347500.0 2689700.0 3903100.0 False True 3038885.0261429935 2540015.8305636784 3192775.849187965 1.0 0.8358380816359845 1.0506405545853417 21.53511066196947 -6.7024506166468845 1.8219670815636229 0.8983083180870461 1.0500351123481917 0.42927107962925426 0.06926419344793847 0.39045698936413775 2.5215224354537686 0.030308022077887825 0.07771403737660913 1.9840352474138306e-07 6.7024506166468845 0.15172679426114555 DCIQYIK(ub)EQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DCIQYIKEQR 10 1 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 19679600.0 11866700.0 3594200.0 4218700.0 True False 18002651.471976627 2952786.9283872256 3384872.0958781047 1.0 0.16401955750704872 0.18802075356216724 24.101706069864317 -10.084593140040715 6.9885562767186995 1.0000003300228983 0.1760201580556077 0.9993640576722898 0.009798447258591273 5.038288624954685e-08 6.6047908980205284e-09 0.00948730950888662 0.00316243525426794 8.230133121966585e-11 10.084593140040715 -0.8239801719672907 DCIQYIK(ub)EQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DCIQYIKEQR 10 1 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 6031150.0 3497500.0 1738200.0 795450.0 True False 2908326.21552115 1728835.9715943143 961774.9172547502 1.0 0.5944436227160027 0.33069705596365073 21.471757669090383 -8.388729895483953 0.19363640002886975 1.3116056167493557 4.49295673570231e-22 0.9997689622421566 0.004184210093815444 0.11541163941094498 0.04561369315773383 0.13393650328550408 0.12414720914535361 4.085734149202362e-09 8.388729895483953 -1.3116056167493557 down DCIVHLCISKPERPMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DCIVHLCISKPERPMK 16 2 P31321;C9JSK5;C9J4C2;C9IZL8 P31321 PRKAR1B cAMP-dependent protein kinase type I-beta regulatory subunit 0 13084800.0 3666200.0 4752300.0 4666300.0 False True 5021693.215329689 4542327.672245441 3564216.0454651527 1.0 0.9045410536786891 0.7097637973153545 22.259742463675973 -6.9596515838522555 0.44031797570789316 1.0069413619898988 0.5997654136882307 0.9997570523644084 0.0018825432742249695 0.07982583745023601 0.02159309188158681 0.0025690392312424926 0.0161375420731537 1.0973582073099472e-07 6.9596515838522555 -0.40717594830166814 DCLGCAK(ub)TGSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DCLGCAKTGSGK 12 1 Q9Y6V7;M0R1S3;M0QZC0;M0R0K1 Q9Y6V7 DDX49 Probable ATP-dependent RNA helicase DDX49 1 2056350.0 602230.0 665400.0 788720.0 True False 789529.3620036164 566124.9137088852 707110.8203364718 1.0 0.7170409879022233 0.8956105426427863 19.59063339426434 -10.400299725841668 5.811666579798144 1.0000633593973696 0.806325765757654 0.6106584402048831 0.07290071545172896 5.986730299832944e-05 6.177714304778814e-06 0.0706088545649138 0.02352860473926253 3.978325139640967e-11 10.400299725841668 -0.19373759363971554 DCLGCAK(ub)TGSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DCLGCAKTGSGK 12 1 Q9Y6V7;M0R1S3;M0QZC0;M0R0K1 Q9Y6V7 DDX49 Probable ATP-dependent RNA helicase DDX49 1 3842130.0 377020.0 742010.0 2723100.0 True False 571966.9038540318 609592.5181494086 2184878.091422872 1.0 1.065782852192754 3.8199379661667656 19.125572144120436 -6.9120416059775 0.8817276224261389 0.9201331444853615 4.191845009038615 0.9916692251903426 0.11994202380811644 0.10308315925123258 0.13156270692356273 0.09920034713904204 0.27786665653079007 1.224498885056303e-07 6.9120416059775 3.2717118645532537 up DCLGCAK(ub)TGSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DCLGCAKTGSGK 12 1 Q9Y6V7;M0R1S3;M0QZC0;M0R0K1 Q9Y6V7 DDX49 Probable ATP-dependent RNA helicase DDX49 1 3966790.0 377020.0 420170.0 3169600.0 True False 488059.8221752645 396787.1701408856 2592765.322842396 1.0 0.812988802012876 5.312392467149903 18.896698466212886 -6.897199902728742 0.9787745864272555 0.7982898091933212 5.758760049317851 0.9851217656917282 0.2535111712755613 0.1134967568566764 0.18926015740348695 0.19523059686792973 0.5011968710819314 1.2670685087906274e-07 6.897199902728742 4.96047024012453 up DCLINAAK(ub)TSMSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DCLINAAKTSMSSK 14 1 P17987;E7ERF2;F5H7Y1 P17987 TCP1 T-complex protein 1 subunit alpha 1 24407500.0 2528400.0 5959100.0 15920000.0 True False 3835767.650799783 4895652.046339188 12773405.022016108 1.0 1.2763161098452904 3.3300778839804774 21.871083901986985 -6.931492004061988 0.7344467722554111 0.9704325632114907 3.768177259934227 0.9968233414892912 0.058583653978712 0.0918706322058351 0.07394026005303715 0.053854042711528514 0.18432928442526586 1.1708681593591365e-07 6.931492004061988 2.797744696722736 up DCLINAAK(ub)TSMSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DCLINAAKTSMSSK 14 1 P17987;E7ERF2;F5H7Y1 P17987 TCP1 T-complex protein 1 subunit alpha 1 23958500.0 2528400.0 2913100.0 18517000.0 True False 3273063.6422151043 2750983.424179296 15147096.000464635 1.0 0.840491883108487 4.627803689821799 21.642210224079435 -6.897068515536494 0.979627540102201 0.8296234942206476 5.0024862220901785 0.9850501521782994 0.2138460768207526 0.11359494336888377 0.18984483778480066 0.16458351249015776 0.4222488688251037 1.2674518932574533e-07 6.897068515536494 4.172862727869531 up DCLNVLNK(ub)SNEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DCLNVLNKSNEGK 13 1 Q99471 Q99471 PFDN5 Prefoldin subunit 5 1 20700000.0 10643800.0 6583800.0 3472400.0 True False 13954124.874705834 5601522.703451389 3113109.357612801 1.0 0.4014241490417703 0.22309599387746828 23.73418831362369 -13.999999999999998 0.1697108260022254 4.016356413178173 0.06530493048084392 0.9995142328442617 0.007323431216094651 12.088731148162113 0.1304489422962354 12.003860132420659 0.14577252717676892 1.0000000000000041e-14 13.999999999999998 -3.951051482697329 DCLNVLNK(ub)SNEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DCLNVLNKSNEGK 13 1 Q99471 Q99471 PFDN5 Prefoldin subunit 5 1 21455360.0 9746500.0 8186960.0 3521900.0 True False 9437102.69246436 11456055.822432384 2599408.735264757 1.0 1.2139378150012274 0.27544563410763945 23.169912571623865 -6.846763178403545 1.250516774782779 1.1139287197101047 0.24018862001277086 0.9354719899143634 0.10201494348767627 0.16105612089054516 0.4862783414787942 0.06388260115347615 0.1475626093035297 1.4231045971872562e-07 6.846763178403545 -0.8737400996973338 down DCLNVLNK(ub)SNEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DCLNVLNKSNEGK 13 1 Q99471 Q99471 PFDN5 Prefoldin subunit 5 1 62876300.0 33298300.0 17107000.0 12471000.0 True False 50515955.531809166 14054122.192398954 10006101.383766532 1.0 0.27821154810284204 0.1980780384816404 25.59023580120364 -13.999999999999998 0.31033752882913357 7.990835755875092 0.1803959383355381 0.9996727380980095 0.0065239116777766094 17.29381297190302 0.17726441172106266 78.08334687382381 0.027730782035345514 1.0000000000000041e-14 13.999999999999998 -7.810439817539554 DCLNVLNK(ub)SNEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DCLNVLNKSNEGK 13 1 Q99471 Q99471 PFDN5 Prefoldin subunit 5 1 21265400.0 10643800.0 6000900.0 4620700.0 True False 14579100.497879598 5735760.3956774 3529385.8263036753 1.0 0.3934234760581845 0.24208529372693421 23.79739837514658 -13.999999999999996 0.19496778590262462 4.309374368193834 0.1387783356849925 0.9994874358244429 0.0074144309239188595 12.43584551346071 0.14002329471234018 15.662624996132642 0.1001092073068318 1.0000000000000082e-14 13.999999999999996 -4.170596032508842 DCLNVLNK(ub)SNEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DCLNVLNKSNEGK 13 1 Q99471 Q99471 PFDN5 Prefoldin subunit 5 1 24142000.0 9746500.0 10086800.0 4308700.0 True False 8104646.593159929 10032460.406326972 5209629.248822098 1.0 1.237865253099877 0.6427953629981674 22.95031784705814 -6.798248184047383 1.463263602409642 1.1315338170416078 0.6349509765165771 0.8269313966531177 0.10174036799694622 0.22326959600633003 0.9439963738511776 0.054706029438759185 0.1273524352094089 1.591299095605547e-07 6.798248184047383 -0.49658284052503077 DCLNVLNK(ub)SNEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DCLNVLNKSNEGK 13 1 Q99471 Q99471 PFDN5 Prefoldin subunit 5 1 68674100.0 33298300.0 18531800.0 16844000.0 True False 43105305.75762186 17500489.039238587 13778564.834035005 1.0 0.4059938499831696 0.31964892933391814 25.36136212329609 -13.999999999999998 0.27161126675106445 5.624678832511532 0.2914325131747811 0.9995868027411677 0.006147573176125721 14.962648081745733 0.1649939676995702 38.246108480439204 0.03557446126837063 1.0000000000000041e-14 13.999999999999998 -5.333246319336751 DCQLNAHK(ub)DHQYQFLEDAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DCQLNAHKDHQYQFLEDAVR 20 1 Q13263;Q13263-2;M0R3C0;M0R2I3 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 36536000.0 10976000.0 11612000.0 13948000.0 True False 14389642.291735187 9879534.86322148 12504794.758663556 1.0 0.6865726515589532 0.8690135936072427 23.77852739316577 -10.221453586908165 5.324727181389777 1.0000158931375898 0.7777931234605198 0.6641953446518761 0.07448120270196552 1.40535839933044e-05 2.0547782492959986e-06 0.07212127007436073 0.024038704805831517 6.005461859051503e-11 10.221453586908165 -0.22222276967707 DCQLNAHK(ub)DHQYQFLEDAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DCQLNAHKDHQYQFLEDAVR 20 1 Q13263;Q13263-2;M0R3C0;M0R2I3 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 145667000.0 25046000.0 35164000.0 85457000.0 True False 37996613.10786717 28888709.462413996 68566386.4928664 1.0 0.7602969606897045 1.804539428243666 25.179367491445397 -6.846327526163823 1.2527621506666855 0.8723861391263608 1.8434003520713493 0.9347776140514577 0.11405951436313554 0.161543691685835 0.489740440738376 0.07130805407003066 0.16466217106513883 1.4245328671595038e-07 6.846327526163823 0.9710142129449886 DCQLNAHK(ub)DHQYQFLEDAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DCQLNAHKDHQYQFLEDAVR 20 1 Q13263;Q13263-2;M0R3C0;M0R2I3 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 52342000.0 10976000.0 15051000.0 26315000.0 True False 15034123.815247018 14385997.052998815 20099938.974437065 1.0 0.9568896218886466 1.3369544658167904 23.841737454688662 -6.878696873701567 1.0869856342448037 0.9737114018709392 1.3632311724589232 0.9726214623213186 0.028115250925381547 0.12879329239177137 0.2792836852580081 0.019946681339974452 0.04808269960324756 1.322218186233746e-07 6.878696873701567 0.38951977058798404 DCQLNAHK(ub)DHQYQFLEDAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DCQLNAHKDHQYQFLEDAVR 20 1 Q13263;Q13263-2;M0R3C0;M0R2I3 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 24936200.0 8089800.0 6012400.0 10834000.0 True False 6727027.1389057925 5980010.007832045 13099339.30924377 1.0 0.8889528590194961 1.9472701742919516 22.681537647782697 -6.8809818447049915 1.0743431788757174 0.9302458076197664 2.023688489788348 0.9744673337899603 0.07588246801707739 0.1267623123603706 0.2670797328139267 0.05436146591868854 0.13179014365627614 1.3152798151472109e-07 6.8809818447049915 1.0934426821685816 DCQLNAHK(ub)DHQYQFLEDAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DCQLNAHKDHQYQFLEDAVR 20 1 Q13263;Q13263-2;M0R3C0;M0R2I3 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 138455000.0 25046000.0 30617000.0 82792000.0 True False 32422540.730469663 28913137.035493944 67724705.51765767 1.0 0.8917603736194032 2.088815496621835 24.950493813537847 -6.884816619201686 1.0525359514468005 0.927464143353487 2.181904824113489 0.977368851580729 0.08132506956010636 0.1234505755412551 0.24721044835430744 0.05923597250891948 0.14517627877692996 1.303717156674856e-07 6.884816619201686 1.254440680760002 up DCTALLHLFHAAVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DCTALLHLFHAAVQR 15 0 Q5T196;Q8NFF5-3;Q8NFF5-2;Q8NFF5 Q5T196 FLAD1 FAD synthase;Molybdenum cofactor biosynthesis protein-like region;FAD synthase region 0 4745340.0 895040.0 1627200.0 2223100.0 False True 1225960.4755465286 1555304.9235691733 1698049.5661816855 1.0 1.2686419787520673 1.3850769254406032 20.225481037217317 -12.966018512697005 0.12430216429706661 4.255078406415195e-17 1.5702231294115432 0.9996986544119629 0.0027991573208539567 8.293276765028564 0.09922479207020185 2.194185016769318 0.15369347308141845 1.0813878539303474e-13 12.966018512697005 1.5702231294115432 DCVGPEVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DCVGPEVEK 9 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 11081010.0 6491500.0 957810.0 3631700.0 False True 6285430.885767446 1340268.5279131648 2680448.8213353613 1.0 0.21323415248237498 0.4264542670264492 22.583580218576454 -10.106576936996772 5.279133109405969 1.000012040022693 0.3198442097618239 0.9313539471642652 0.0870467472592408 1.3385449457902306e-05 2.265377262353056e-06 0.08428426731114858 0.028094216872441003 7.823895893576858e-11 10.106576936996772 -0.6801678302608691 DDAMLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDAMLLK 7 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 7041570.0 3335800.0 349270.0 3356500.0 False True 3229906.8549245996 488735.3324189884 2477331.9571583965 1.0 0.15131561198856852 0.7669979564213248 21.623061129947402 -10.359789259654054 7.744605156891092 1.0000059551401341 0.4591567842501045 0.5071191750780327 0.251351264583456 2.5844756856767355e-05 2.136719786475156e-06 0.24337249267504446 0.08112327181499168 4.367277018914456e-11 10.359789259654054 -0.5408491708900296 DDANNDPQWSEEQLIAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDANNDPQWSEEQLIAAK 18 0 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 15496700.0 2461800.0 6154700.0 6880200.0 False True 3227443.64010511 5236442.750832695 6168302.903538636 1.0 1.6224738011729172 1.9112039097723017 21.621960471719287 -10.397524905878138 0.16514777960339966 3.744708797187417e-16 2.2603511708802064 0.9996051491762958 0.0075553693591749365 2.135154124370961 0.08432725711174582 1.1109554473222973 0.22992663289893392 4.003825065747071e-11 10.397524905878138 2.260351170880206 DDANNDPQWSEEQLIAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDANNDPQWSEEQLIAAK 18 0 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 13649800.0 2461800.0 5480500.0 5707500.0 False True 3371993.987643505 5238353.388410072 4359506.049652272 1.0 1.5534883536583228 1.2928570055662771 21.68517053324218 -10.018801452062092 4.36358598310756 0.9999784540632565 1.4231726795821558 0.7785142095622343 0.10640230256847458 12135086.071127726 5572436.133686812 2419.610300500938 0.03642433884261057 9.576317751254006e-11 10.018801452062092 0.4231942255188993 DDDSVTAK(ub)DLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDDSVTAKDLSK 12 1 F8W822;R4GNG3;F8WAK2;F8VXI9;Q14161-2;Q14161-11;Q14161-7;Q14161-9;Q14161-6;Q14161-10;Q14161-8;Q14161-4;Q14161-5;Q14161-3;Q14161 F8W822 GIT2 ARF GTPase-activating protein GIT2 1 3775140.0 604240.0 1002800.0 2168100.0 True False 585058.7319442532 1403223.2695329161 1600209.568394198 1.0 2.398431461521407 2.73512637453751 19.158221933374886 -10.203149227699175 0.3248681578331825 3.92388290682066e-13 2.8232229653728913 0.998952419282271 0.024315815734510433 1.6337385811306713 0.14999793070986148 1.5595159976402608 0.10893076575093681 6.263985911980238e-11 10.203149227699175 2.8232229653724987 DDDSVTAK(ub)DLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDDSVTAKDLSK 12 1 F8W822;R4GNG3;F8WAK2;F8VXI9;Q14161-2;Q14161-11;Q14161-7;Q14161-9;Q14161-6;Q14161-10;Q14161-8;Q14161-4;Q14161-5;Q14161-3;Q14161 F8W822 GIT2 ARF GTPase-activating protein GIT2 1 1381460.0 0.0 621000.0 760460.0 True False 0.0 593562.166627616 580855.0101653198 0.0 DDDSVTAK(ub)DLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDDSVTAKDLSK 12 1 F8W822;R4GNG3;F8WAK2;F8VXI9;Q14161-2;Q14161-11;Q14161-7;Q14161-9;Q14161-6;Q14161-10;Q14161-8;Q14161-4;Q14161-5;Q14161-3;Q14161 F8W822 GIT2 ARF GTPase-activating protein GIT2 1 2833920.0 604240.0 831380.0 1398300.0 True False 502452.33237069263 826901.1909239914 1690678.0649912835 1.0 1.645730624878324 3.3648526558016996 18.938627208809162 -6.9541002273074755 0.5118558715809708 0.9688376513639887 4.117405033161114 0.999485005674676 0.02264916068588903 0.08187990485349955 0.02946296817460649 0.026004602092160864 0.141901540213049 1.1114751893200148e-07 6.9541002273074755 3.148567381797125 DDDSVTAK(ub)DLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DDDSVTAKDLSK 12 1 F8W822;R4GNG3;F8WAK2;F8VXI9;Q14161-2;Q14161-11;Q14161-7;Q14161-9;Q14161-6;Q14161-10;Q14161-8;Q14161-4;Q14161-5;Q14161-3;Q14161 F8W822 GIT2 ARF GTPase-activating protein GIT2 1 14382000.0 1692500.0 1105500.0 11584000.0 True False 2190974.6141627333 1043977.953187399 9475830.86187732 1.0 0.47649020962588756 4.324938682823784 21.06314133789069 -6.872553156056491 1.1204535083990041 0.6987945036762283 4.561582565541103 0.9671679135015117 0.30880150699258996 0.134432819740385 0.31386903966284047 0.21353531040946547 0.5079366840258677 1.3410557850356522e-07 6.872553156056491 3.862788061864875 up DDEACGISIGTSDQSEITE ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDEACGISIGTSDQSEITE 19 0 A2ABS3 A2ABS3 LY6G6E 0 3599450.0 1495900.0 966050.0 1137500.0 False True 2048974.655177479 923366.7166998539 868845.9275478682 1.0 0.45064818853011795 0.4240393727430514 20.966470708345902 -13.75099741948388 0.4338589889331948 9.999999990567401 0.4236037901277179 0.9998772997070295 0.002940510662332879 25.823806217099925 0.221380325896225 219.6887377575045 0.006240517101096163 1.7742000229033557e-14 13.75099741948388 -9.576396200439683 DDEFTHLYTLIVRPDNTYEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDEFTHLYTLIVRPDNTYEVK 21 1 P27797;K7EJB9 P27797 CALR Calreticulin 0 15495400.0 4707500.0 2806900.0 7981000.0 False True 4558062.989255227 3927709.807790126 5890536.675132177 1.0 0.861705908200251 1.2923333198812752 22.119989431105584 -6.820278543775298 1.3705329194209417 0.9254768625551109 1.3017996989249097 0.8850290986599363 0.060868090225644496 0.19313659363305338 0.712746163778744 0.0348978098778845 0.0804332717411977 1.5125908057711125e-07 6.820278543775298 0.3763228363697988 DDEK(ub)SFSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDEKSFSR 8 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1;H3BQD1;H3BUV0;H3BTM1;H3BRA2 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 68252000.0 19290000.0 26144000.0 22818000.0 True False 25289376.804625746 22243417.108513817 20457012.24571156 1.0 0.8795557628942923 0.8089172146768645 24.592028149929426 -13.999999999958112 0.0578133697485549 1.78560594419158 0.47291724488549863 0.9999595874337933 0.0005014620312966742 12.486467867579341 0.06063073724439338 1.4479156921303553 0.3163372645342131 1.0000000000964513e-14 13.999999999958112 -1.3126886993060813 DDEK(ub)SFSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDEKSFSR 8 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1;H3BQD1;H3BUV0;H3BTM1;H3BRA2 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 78028000.0 23238000.0 29186000.0 25604000.0 True False 22500322.409838125 40840122.00297936 18897544.29646463 1.0 1.815090524441653 0.8398788227230822 24.423442338353496 -6.684922459446027 1.8843723690966425 1.5134035838251434 0.843426909968463 0.34690695581151665 0.345085791119293 0.42761944327375495 2.939765262087941 0.1467209819202428 0.3845471983820633 2.0657489493962733e-07 6.684922459446027 -0.6699766738566804 DDEK(ub)SFSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DDEKSFSR 8 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1;H3BQD1;H3BUV0;H3BTM1;H3BRA2 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 35361600.0 8391600.0 15320000.0 11650000.0 True False 12730670.708136136 12586026.304293675 9347372.393623607 1.0 0.9886381159988673 0.7342403717700221 23.6018050930197 -6.916249267528954 0.852074961015809 1.0064070711912223 0.6965574088261312 0.9930741504926854 0.010210465877163106 0.1004293266665234 0.11741944272080518 0.008626897745895507 0.024983761156855654 1.2126926139937754e-07 6.916249267528954 -0.30984966236509115 DDEK(ub)SFSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDEKSFSR 8 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1;H3BQD1;H3BUV0;H3BTM1;H3BRA2 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 68763000.0 19290000.0 17971000.0 31502000.0 True False 26422034.292648997 17176981.79785007 24061876.40405532 1.0 0.6501006549154681 0.9106746338131009 24.655238211452318 -10.284704797279483 5.5064277209483095 1.0000252892201693 0.7803876443642778 0.48641244528370464 0.10637888142434886 3.303029496985535e-05 4.290716467156439e-06 0.10301275906386084 0.03433363634538629 5.191528024379512e-11 10.284704797279483 -0.21963764485589155 DDEK(ub)SFSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDEKSFSR 8 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1;H3BQD1;H3BUV0;H3BTM1;H3BRA2 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 69589000.0 23238000.0 31656000.0 14695000.0 True False 19323426.617950123 31485462.84477595 17767656.55799681 1.0 1.6293933507387421 0.9194878791058667 24.203847613787772 -6.6727469163974265 1.9273176979162745 1.4007901018498605 0.9223042236649656 0.291303292350098 0.2671855524236147 0.4549064979812338 3.2602023367941766 0.11149318081659448 0.2968533755070914 2.124482135934066e-07 6.6727469163974265 -0.47848587818489496 DDFTEFGK(ub)LLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDFTEFGKLLK 11 1 O75822-3;O75822;H0YGJ7;H0YLP3 O75822-3 EIF3J Eukaryotic translation initiation factor 3 subunit J 1 4397400.0 1194100.0 1519400.0 1683900.0 True False 1565476.6636808484 1292711.4425748137 1509666.181109374 1.0 0.8257621927977568 0.9643492082211884 20.57817057192861 -9.955408070001749 5.06958347608598 1.0000005312670182 0.8950557005230851 0.43328636107479646 0.056577912132338364 3.397135953472965e-07 6.996398922778872e-08 0.05478160499549963 0.018260442620227375 1.1081331064465838e-10 9.955408070001749 -0.10494483074393302 DDFTEFGK(ub)LLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DDFTEFGKLLK 11 1 O75822-3;O75822;H0YGJ7;H0YLP3 O75822-3 EIF3J Eukaryotic translation initiation factor 3 subunit J 1 40463000.0 10270000.0 11238000.0 18955000.0 True False 13294717.451965317 10612595.421004051 15505384.49472414 1.0 0.7982565601223232 1.1662816115307533 23.66434978063389 -6.757880940279364 1.6205884368882715 0.8825070521986238 1.1674805496734986 0.6822030950730555 0.08482963499896268 0.28649171380525035 1.4824650991937678 0.04131160923298613 0.09948154630697018 1.746300827185501e-07 6.757880940279364 0.28497349747487477 DDGEEEFAGAK(ub)LEDSEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDGEEEFAGAKLEDSEVR 18 1 Q8N163;Q8N163-2;H0YB24;G3V119;A0A087X2B6 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 1 6198900.0 2490800.0 2606800.0 1101300.0 True False 3265462.9209415135 2217875.6012268127 987348.040415554 1.0 0.6791917883995892 0.30236081815036414 21.63885609598287 -7.213568701899666 0.3204165452043713 1.0607402752612618 2.0117368650255685e-14 0.9998826729442476 0.0030883024967989317 0.09150143396416356 0.018463333642270534 0.009745247708682616 0.042013642783853396 6.11549053152854e-08 7.213568701899666 -1.0607402752612416 down DDGEEEFAGAK(ub)LEDSEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDGEEEFAGAKLEDSEVR 18 1 Q8N163;Q8N163-2;H0YB24;G3V119;A0A087X2B6 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 1 9205900.0 2338100.0 2962900.0 3904900.0 True False 2263878.295311234 4146001.4213193767 2882089.5455110474 1.0 1.8313711606786671 1.2730761858887043 21.110364971190762 -9.972119267180293 7.072651404320802 0.9999999704628124 1.5522236732836865 0.5660648400030761 0.22792296903257037 1.0651455492125443e-07 1.5808496220088195e-08 0.22068547897414942 0.07356182194010744 1.0663032497998884e-10 9.972119267180293 0.5522237028208741 DDGEEEFAGAK(ub)LEDSEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDGEEEFAGAKLEDSEVR 18 1 Q8N163;Q8N163-2;H0YB24;G3V119;A0A087X2B6 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 1 7272600.0 2490800.0 1908900.0 2872900.0 True False 3411716.0713390415 1824558.4861118458 2194380.189232766 1.0 0.5347920072949497 0.6431895689290196 21.70206615750576 -9.84510980191024 6.453949351390887 1.0000000144626788 0.5889907881119476 0.950419324073679 0.04425311922776753 9.24153183732757e-09 1.5828658052861985e-09 0.04284789972359187 0.014282632815542344 1.4285327394291111e-10 9.84510980191024 -0.4110092263507312 DDGEEEFAGAK(ub)LEDSEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDGEEEFAGAKLEDSEVR 18 1 Q8N163;Q8N163-2;H0YB24;G3V119;A0A087X2B6 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 1 7667400.0 2338100.0 3144700.0 2184600.0 True False 1944233.745392423 3127758.8769259234 2641389.7595508536 1.0 1.6087360299852314 1.3585762338559335 20.89077024662504 -10.069156569573039 4.585085060908555 0.9999769261441007 1.4836561317343635 0.8328874020479371 0.10212730919175977 70872339.34083419 0.37054423327977015 19524.440207422827 0.03496089435152911 8.52792614262983e-11 10.069156569573039 0.4836792055902628 DDGLFSGDPNWFPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDGLFSGDPNWFPK 14 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 23897890.0 644890.0 12051000.0 11202000.0 False True 845457.0351236445 10253037.774430072 10042924.49717157 1.0 12.127213268656057 11.878692919862964 19.689371915306225 -10.28577535079518 6.4822671012066655 0.9997419437899441 12.002953094259512 0.9996175272371687 0.10145800754026978 0.00037838471336345083 4.169157192540281e-05 0.09823711359860737 0.032745431128569966 5.1787464572102804e-11 10.28577535079518 11.003211150469568 DDGLFSGDPNWFPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDGLFSGDPNWFPK 14 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 22043400.0 6692500.0 2832900.0 12518000.0 False True 6480050.250789289 3964091.74337834 9239160.268049702 1.0 0.6117378091158323 1.4257852810515388 22.62757357013213 -6.776998096761375 1.5474394433163348 0.7792984659603263 1.4316508207089287 0.7566596380876816 0.16399662777942245 0.2552710770235414 1.207119398274219 0.08348764737161345 0.1975062852488649 1.6710979376622697e-07 6.776998096761375 0.6523523547486024 DDGLFSGDPNWFPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDGLFSGDPNWFPK 14 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 19739390.0 644890.0 9420600.0 9673900.0 False True 883323.2604969632 9004366.74224174 7389124.060224449 1.0 10.193738968422306 8.365141495387864 19.752581976829116 -9.406607134345707 8.223221762985883 1.0000000473358024 9.279440231907563 0.9647068120897248 0.7465217923220157 0.0 0.0 0.7228166496193305 0.2409388724356365 3.92096409727065e-10 9.406607134345707 8.27944018457176 DDGLMDLAINDYDFNSGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDGLMDLAINDYDFNSGKR 19 1 A0A0U1RR27;Q7Z401;Q7Z401-2;H3BTW5 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 9495600.0 2227800.0 3607800.0 3660000.0 True False 1852514.4082739148 3588364.0653077723 4425289.078072021 1.0 1.9370235660683686 2.3888014356634857 20.8210533327268 -9.64540555877268 0.1941665375719782 1.6586755923859788e-18 2.839914590117421 0.9994990825409797 0.012945204954303468 1.0921691133768907 0.08103496197721301 0.8899150513578266 0.2748332917586253 2.2625304938108846e-10 9.64540555877268 2.839914590117421 DDGSTLMEIDGDK(ub)GK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDGSTLMEIDGDKGK 15 1 O96019;O96019-2;H7C5S0;C9JQT2 O96019 ACTL6A Actin-like protein 6A 1 16197100.0 8590200.0 4029500.0 3577400.0 True False 8317508.80303775 5638500.3635649 2640371.6203004494 1.0 0.6779073514783162 0.3174474091733 22.98772005734451 -7.213733745085353 0.30231605759936114 1.0712871471117813 6.297165041773815e-17 0.9999108133282588 0.0026329221461425995 0.09179055719674616 0.016964337209750303 0.010169517672019724 0.04139909397765534 6.113166927794702e-08 7.213733745085353 -1.0712871471117813 down DDGSTLMEIDGDK(ub)GK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DDGSTLMEIDGDKGK 15 1 O96019;O96019-2;H7C5S0;C9JQT2 O96019 ACTL6A Actin-like protein 6A 1 19152900.0 9736000.0 6535200.0 2881700.0 True False 14770223.796941394 5368942.500249342 2312130.7319060196 1.0 0.3634977082311467 0.15653999314382858 23.81618835004961 -11.902459612495846 0.19333547842244966 2.493747420327226 2.882960065206567e-16 0.9994134600895161 0.008692455575440062 5.059270036860007 0.12193215680737281 3.188343045443617 0.13602322535868114 1.2518156810506466e-12 11.902459612495846 -2.4937474203272254 DDGSTLMEIDGDK(ub)GKQGGPTYYIDTNALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDGSTLMEIDGDKGKQGGPTYYIDTNALR 29 2 O96019;O96019-2;H7C5S0;C9JQT2 O96019 ACTL6A Actin-like protein 6A 1 38968200.0 17631400.0 16154500.0 5182300.0 True False 17071700.85794041 22605076.094604615 3824900.1643324806 1.0 1.3241255972506405 0.22404915574381323 24.025103465815295 -6.827797801739795 1.3377223394514683 1.1734705896232167 0.19575566381865106 0.9014032169594917 0.14492990858702673 0.18354004189799655 0.6431243665109331 0.08508406236462097 0.19582838596976346 1.486627623344617e-07 6.827797801739795 -0.9777149258045656 down DDGSTLMEIDGDK(ub)GKQGGPTYYIDTNALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DDGSTLMEIDGDKGKQGGPTYYIDTNALR 29 2 O96019;O96019-2;H7C5S0;C9JQT2 O96019 ACTL6A Actin-like protein 6A 1 67009000.0 30736000.0 16088000.0 20185000.0 True False 46628759.10258746 13216970.703882294 16195425.902600223 1.0 0.28345104948651473 0.34732697619014113 25.474716701001412 -10.093933161770247 4.990858657348414 1.0000205774871405 0.3153890128354706 0.9935133318206232 0.026077237888455545 72564430.1423093 0.9924300751076366 17159.561135197495 0.008926932141581944 8.055023990525275e-11 10.093933161770247 -0.6846315646516699 DDGSTLMEIDGDK(ub)GKQGGPTYYIDTNALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDGSTLMEIDGDKGKQGGPTYYIDTNALR 29 2 O96019;O96019-2;H7C5S0;C9JQT2 O96019 ACTL6A Actin-like protein 6A 1 27876700.0 17631400.0 5946700.0 4298600.0 True False 14661290.30345663 5914663.946772474 5197417.3855192205 1.0 0.4034204237384208 0.35449931608637797 23.80550874124957 -13.99999999999998 0.3543928608453294 8.538547238241192 0.348128296740297 0.9997629886376314 0.0045175801589539075 21.105130036627294 0.19195868698163013 120.02198543984666 0.01438111134294909 1.000000000000045e-14 13.99999999999998 -8.190418941500894 DDGSTLMEIDGDK(ub)GKQGGPTYYIDTNALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DDGSTLMEIDGDKGKQGGPTYYIDTNALR 29 2 O96019;O96019-2;H7C5S0;C9JQT2 O96019 ACTL6A Actin-like protein 6A 1 66453000.0 30736000.0 11443000.0 24274000.0 True False 39788357.897137895 10806186.99079457 19856381.07227298 1.0 0.2715916806300743 0.49905002673410936 25.24584302309386 -10.111690020217019 5.122324986197385 1.000017315541375 0.385320853681743 0.9068654313279022 0.0928594809525367 52860991.93478104 104349879.39591037 7099.747626780182 0.03178826152879844 7.732322864597041e-11 10.111690020217019 -0.614696461859632 DDGSWEVIEGYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDGSWEVIEGYR 12 0 P00367;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 1839990.0 809390.0 1030600.0 0.0 False True 1061118.1281439108 876838.4972473354 0.0 1.0 0.8263344805738885 0.0 20.017153841411876 -7.211165263921554 0.883258867603571 0.9903110993328819 1.2218950868243912e-15 0.9892371652617817 0.045260493706230205 0.09404246845071186 0.1398825234971303 0.03818482477695722 0.06706992064912852 6.149428213799016e-08 7.211165263921554 -0.9903110993328806 down DDGVFVQEVTQNSPAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDGVFVQEVTQNSPAAR 17 0 Q09666;E9PLK4;E9PQE3;E9PJZ0;E9PKR9;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 16897000.0 1637400.0 9028400.0 6231200.0 False True 2146647.2566041546 7681397.91242757 5586455.197891046 1.0 3.578323308031056 2.6024094926189347 21.033653712100893 -10.26387857547216 6.102789967240904 0.9999327290731359 3.090366400324999 0.8594975196288751 0.3984151467820775 0.00036467667551276565 4.39865994280281e-05 0.38577586265845476 0.12858793569697888 5.446549117907587e-11 10.26387857547216 2.090433671251863 DDGVFVQEVTQNSPAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDGVFVQEVTQNSPAAR 17 0 Q09666;E9PLK4;E9PQE3;E9PJZ0;E9PKR9;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 10654000.0 3529600.0 1672600.0 5451800.0 False True 3417554.7800053563 2340477.902493775 4023810.0295057762 1.0 0.6848399084008557 1.1773944496946644 21.70453303230801 -6.7338760693057 1.7089915096675925 0.8111610668217016 1.1773205571067544 0.5771650631476729 0.13245063295996493 0.32902955755576274 1.884316408321253 0.06137296133757123 0.1516352924032762 1.8455419896955515e-07 6.7338760693057 0.3661594902850528 DDGVFVQEVTQNSPAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDGVFVQEVTQNSPAAR 17 0 Q09666;E9PLK4;E9PQE3;E9PJZ0;E9PKR9;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 14258300.0 1637400.0 6489300.0 6131600.0 False True 2242791.0290711983 6202581.268754583 4683442.364265943 1.0 2.76556361620692 2.0882205714036077 21.096863773623785 -10.351560282495555 5.6210874915736415 0.9996768123575855 2.426892093805274 0.8554292460589584 0.2765241400985751 0.0011202133187435796 0.00012922609664081915 0.2677992448744767 0.08924778245217053 4.450816788135911e-11 10.351560282495555 1.4272152814476882 DDGYSTK(ub)DSYSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DDGYSTKDSYSSR 13 1 P38159;P38159-2;H3BT71;H0Y6E7;Q96E39;H3BUY5 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 4471800.0 1318600.0 1545700.0 1607500.0 True False 2000412.6025726106 1269857.758390778 1289776.9204077201 1.0 0.6347979195680382 0.6447554463259307 20.931866168470368 -10.048059421184956 5.177734783590971 1.0000042430284908 0.6397766829459357 0.9994272400472125 0.004065143279815359 1.991121341567126e-07 3.660633053939312e-08 0.003936104408332565 0.0013120193513632462 8.952422680323641e-11 10.048059421184956 -0.3602275600825551 DDGYSTK(ub)DSYSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDGYSTKDSYSSR 13 1 P38159;P38159-2;H3BT71;H0Y6E7;Q96E39;H3BUY5 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 3418550.0 1042200.0 1775900.0 600450.0 True False 866635.4772883891 1766332.874211449 726001.318832881 1.0 2.038149741732381 0.8377239772187293 19.725065771582454 -6.677925860479094 1.908978248982768 1.6580516392682199 0.8423313307043693 0.31480034562702497 0.4401904604367152 0.4431345640272774 3.120288304958636 0.1851384875122925 0.4896415689124743 2.099298229601399e-07 6.677925860479094 -0.8157203085638506 DDGYSTK(ub)DSYSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DDGYSTKDSYSSR 13 1 P38159;P38159-2;H3BT71;H0Y6E7;Q96E39;H3BUY5 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 1 3929200.0 1318600.0 1308600.0 1302000.0 True False 1706953.6934918654 1235775.2596481503 1065049.3596481578 1.0 0.7239653098732637 0.6239474238281282 20.702992490562817 -13.999999999999998 0.1412421480632752 2.3200893494691472 0.5020029735432185 0.9995980272673263 0.0031884240153452707 11.935468295999868 0.11783770383684952 4.3395611352449315 0.10911029868525544 1.0000000000000041e-14 13.999999999999998 -1.8180863759259287 DDHDK(ub)MFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDHDKMFK 8 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 4893500.0 1296300.0 1389700.0 2207500.0 True False 1699461.853387059 1182362.1770081725 1979089.07583523 1.0 0.6957274002071319 1.164538687285548 20.69664654841649 -6.731525447568367 1.7177519154636478 0.8172025231397709 1.1643345114462627 0.5663081048100496 0.1278939942507036 0.3333752552915132 1.9278231639447878 0.05898663959289621 0.1461145484000734 1.855558079466936e-07 6.731525447568367 0.3471319883064917 DDHDK(ub)MFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDHDKMFK 8 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 6169400.0 1025600.0 1568400.0 3575400.0 True False 993042.8893850564 2194670.299097951 2638895.4802991585 1.0 2.2100458324181793 2.657383189091963 19.92149650333537 -9.897964675937263 0.2522115691089853 5.410754695507411e-16 2.907279019378046 0.999083363678189 0.02119618182589558 1.3347992346562885 0.11151035171532094 1.1637356697604695 0.19745710285043772 1.2648392210854322e-10 9.897964675937263 2.9072790193780453 DDHDK(ub)MFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DDHDKMFK 8 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 19411300.0 1085000.0 3555300.0 14771000.0 True False 1646024.324125044 2920828.9373143134 11851505.37564071 1.0 1.774474954291396 7.200079125161448 20.650554224667726 -6.932651731533143 0.7246937144489733 0.9250632221832056 8.393078910849235 0.9970342341352146 0.1502182246681986 0.09128420711945352 0.07110470559914141 0.139081795835346 0.4839648053926965 1.1677456777106031e-07 6.932651731533143 7.468015688666029 DDHDK(ub)MFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDHDKMFK 8 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 6418100.0 1296300.0 1125500.0 3996300.0 True False 1775577.1411903012 1075771.6884692148 3052456.2463820134 1.0 0.605871557767434 1.7191346833490577 20.75985660993938 -6.81101254010819 1.4102947690171446 0.7854598096676568 1.7390610887929303 0.8624491463516748 0.17093733307441183 0.2054234939155281 0.8050731312751018 0.09530081118037675 0.2203486752251942 1.5452098214764734e-07 6.81101254010819 0.9536012791252735 DDHDK(ub)MFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDHDKMFK 8 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 5849900.0 1025600.0 1940700.0 2883600.0 True False 852831.8417836996 1930245.0639012107 3486547.4277400207 1.0 2.2633360638412596 4.08820034257621 19.701901778769646 -6.96587644682944 0.34267757833674495 0.808107003970472 5.604321649773352 0.9999300885093481 0.010599468582250538 0.07766478994727537 0.013818231104281384 0.0255551476827318 0.15764439655036577 1.0817416540363467e-07 6.96587644682944 4.7962146458028805 DDHDK(ub)MFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DDHDKMFK 8 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 11978100.0 1085000.0 2336700.0 8556400.0 True False 1404553.8885474552 2206660.590875615 6999222.996077956 1.0 1.5710757763503633 4.983235640261784 20.421680546760175 -6.9359230621911445 0.6964553332354162 0.957696745543743 5.802604232556668 0.9975797064276363 0.08651858030781331 0.08967665884090602 0.06345345039098824 0.08181435057537602 0.2993296206054719 1.1589826585293754e-07 6.9359230621911445 4.844907487012925 up DDHTLK(ub)FLYDDNQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDHTLKFLYDDNQR 14 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 8753540.0 913140.0 2109700.0 5730700.0 True False 884152.870527565 2952114.2119401605 4229657.752685126 1.0 3.3389183141809675 4.7838534417259 19.753936308402718 -8.413305308459837 0.26137974525176694 1.2027332138473337e-15 5.845720536524327 0.9992527243091254 0.042618912568368354 0.13454268765381533 0.06747847733668191 0.5800743005179985 0.5228499655893992 3.86095457018537e-09 8.413305308459837 5.845720536524326 DDHTLK(ub)FLYDDNQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDHTLKFLYDDNQR 14 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 6902040.0 913140.0 1358700.0 4630200.0 True False 759316.3689609669 1351380.413419166 5598353.4123740615 1.0 1.7797330186209044 7.372886508471738 19.534341583836994 -6.932184168370345 0.7286389465752248 0.9214576777731501 8.587728068595066 0.9969503836975215 0.1567420128296664 0.09151954536921962 0.07223943743130759 0.14470155755123726 0.5001447608308853 1.1690035543376372e-07 6.932184168370345 7.666270390821916 DDK(ub)HGSYEDAVHSGALND ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDKHGSYEDAVHSGALND 18 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 1 325240000.0 132650000.0 100760000.0 91830000.0 True False 173905434.58442718 85727000.75940368 82328312.49556026 1.0 0.492951821570505 0.4734085090112104 27.37372777699638 DDK(ub)HGSYEDAVHSGALND ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDKHGSYEDAVHSGALND 18 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 1 373854600.0 117278800.0 135515800.0 121060000.0 True False 113555848.68916939 189627965.64556104 89350754.2778477 1.0 1.6699092810676794 0.7868441415327092 26.758826773004206 -6.703856091806518 1.817165450739368 1.4144031332414801 0.7892745462188279 0.43589997877690834 0.28258204853978725 0.387540547096775 2.4904999859528 0.12393826063799293 0.3172224955359472 1.9776248390217627e-07 6.703856091806518 -0.6251285870226523 DDK(ub)HGSYEDAVHSGALND ddPTM_RPMI8226_Bortezomib_8h_R1 1 DDKHGSYEDAVHSGALND 18 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 1 633305400.0 344589400.0 222240000.0 66476000.0 True False 522767312.65958875 182579535.6309544 53336989.462534174 1.0 0.34925583755816236 0.10202816467460679 28.961593694918143 -9.60404234179343 0.2846356937938445 1.399904245191144 5.605066679519867e-15 0.9987922259963539 0.013162096169944187 1.0054298913805864 0.11929553410210926 0.45285773010847835 0.0914851843972158 2.4886146775171176e-10 9.60404234179343 -1.3999042451911385 DDK(ub)HGSYEDAVHSGALND ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDKHGSYEDAVHSGALND 18 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 1 326166300.0 132650000.0 87111000.0 106405300.0 True False 181694289.7314611 83262147.98244497 81274559.62594205 1.0 0.45825407119565514 0.44731488119997326 27.43693783851927 DDK(ub)HGSYEDAVHSGALND ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDKHGSYEDAVHSGALND 18 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 1 337584500.0 117278800.0 167942700.0 52363000.0 True False 97522518.53176884 167037959.34108412 63311861.2008429 1.0 1.712814249015421 0.6492024832215392 26.539232048438482 -6.726109088001969 1.7373794998754295 1.4308135689274966 0.6502658855893482 0.5411660356119522 0.299752516145019 0.3435746447947186 2.0298559889541634 0.1368266204947833 0.3410367338808681 1.8788448210042496e-07 6.726109088001969 -0.7805476833381484 DDK(ub)HGSYEDAVHSGALND ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DDKHGSYEDAVHSGALND 18 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 1 558168700.0 344589400.0 175204800.0 38374500.0 True False 446077771.1725658 165454498.86260295 31390734.755620755 1.0 0.37090953541057897 0.07037054250227862 28.732720017010593 -8.801507340216686 0.3680050592667959 1.1542227741733224 1.1555154475955105e-16 0.9975878247861956 0.019023769892603865 0.3434327966686498 0.12597953040612792 0.15639981624388355 0.07909856114949422 1.5794019132933538e-09 8.801507340216686 -1.1542227741733222 DDKESVPISDTIIPAVPPPTDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDKESVPISDTIIPAVPPPTDLR 23 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751-14;P02751-10;P02751-9;P02751-8;P02751-4 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 10728200.0 3677300.0 1741500.0 5309400.0 False True 3560566.1243522507 2436890.031802525 3918708.861414208 1.0 0.6844108343152457 1.1005858968922004 21.76367521497133 -6.703952063501402 1.8168977456061681 0.8047915354897864 1.0994379946887596 0.43626167461642684 0.13312084649965425 0.3873760689725311 2.4887903546457912 0.05839369702561061 0.14943812904084214 1.9771878658474482e-07 6.703952063501402 0.29464645919897314 DDLLGFALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDLLGFALR 9 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 8353900.0 2667700.0 2032200.0 3654000.0 False True 3497380.5340435524 1729003.6814535575 3275919.1316430024 1.0 0.4943710484528094 0.9366779221635045 21.73784334697537 -10.254303000536689 8.097546374879764 1.0000002604526959 0.7155244853081574 0.3554812500723564 0.18057102505280706 8.490923034565892e-07 7.818211868639371e-08 0.17483730212709866 0.05827904773642699 5.567971446380839e-11 10.254303000536689 -0.2844757751445385 DDLLGFALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDLLGFALR 9 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 6430100.0 2463100.0 1499000.0 2468000.0 False True 2384910.238732773 2097558.5171817318 1821556.7615870466 1.0 0.8795125632469396 0.7637842011844164 21.185503537621194 -6.971616122619295 0.2161248216925819 1.0560504806565245 0.5839930224001401 0.9999923902965128 0.00026597711474286997 0.07578164621917151 0.007122923924971819 0.0033028038789208775 0.011827998814382007 1.0675393133516115e-07 6.971616122619295 -0.47205745825638445 DDLLGFALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDLLGFALR 9 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 8120800.0 2667700.0 3018200.0 2434900.0 False True 3654020.7818817915 2884845.944147301 1859826.7683396076 1.0 0.7894990522362678 0.5089808951173539 21.801053408498262 -6.9671489437980085 0.31902877363921195 1.0388573765065645 0.2505875702120906 0.9999508327513421 0.0014103402618595553 0.07723915188253784 0.012327570718010614 0.004268964613089515 0.02469631538811432 1.0785767546718893e-07 6.9671489437980085 -0.788269806294474 DDLSGADIK(ub)AICTEAGLMALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDLSGADIKAICTEAGLMALR 21 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 13670400.0 4075700.0 3215800.0 6378900.0 True False 3946319.134425383 4499885.7101754565 4708074.727101947 1.0 1.140274153430999 1.1930293944124928 21.912076199241653 -13.999999999999535 0.1356925765031305 0.3320372995311012 1.2618333625267528 0.9996206468030471 0.0015865681726920842 11.931901643220305 0.11507596333779922 2.1160535506384304 0.06134834252428367 1.0000000000010716e-14 13.999999999999535 0.9297960629956517 DDLSGADIK(ub)AICTEAGLMALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DDLSGADIKAICTEAGLMALR 21 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 66722700.0 8218700.0 21733000.0 36771000.0 True False 12468368.76745298 17854576.349295974 29503195.732698154 1.0 1.4319897560218924 2.366243434322566 23.571769394411614 -6.9584875284728405 0.456257113277494 0.9717261890216303 2.863932631912142 0.9997099027580849 0.00971163927271321 0.08024600113111219 0.023162233199391886 0.012609519039992613 0.07721232022873102 1.1003034419837012e-07 6.9584875284728405 1.8922064428905117 up DDLSGADIK(ub)AICTEAGLMALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDLSGADIKAICTEAGLMALR 21 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 5266700.0 1380200.0 1896600.0 1989900.0 True False 1147697.453227244 1886382.6393543752 2405978.8897419428 1.0 1.6436236170516896 2.0963529046583664 20.130310949791895 -7.671100506344949 0.11604110910254391 2.05285565906842e-20 3.435002196900034 0.9999913649963111 0.0013218594094659651 0.1394300892633578 0.013406604755801273 0.15778087188640466 0.21811614284468805 2.132551331598181e-08 7.671100506344949 3.435002196900034 DDLSGADIK(ub)AICTEAGLMALR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DDLSGADIKAICTEAGLMALR 21 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 116696500.0 12706200.0 26754900.0 77235400.0 True False 16448426.376646712 25265966.295552734 63179349.70212695 1.0 1.536071944938457 3.8410573908655645 23.971446231928738 -6.943217705794062 0.6289156208621065 0.9748558910376195 4.526269104744891 0.9985557224392714 0.046840240486430866 0.08632886585529273 0.04815157909229682 0.0467952328495674 0.19574795059891073 1.1396783394152946e-07 6.943217705794062 3.5514132137072716 DDMIHQLPLLTEK(ub)QYIATIHSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDMIHQLPLLTEKQYIATIHSR 22 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 16014300.0 3646800.0 6907400.0 5460100.0 True False 4780990.11566144 5876842.84483431 4895141.228977545 1.0 1.2292104151362089 1.0238760404340037 22.18887799234905 -10.395308067160416 4.737968124177387 0.9998273256597975 1.1265432277851737 0.3361654533188916 0.08382740744587325 0.0001531082445644558 1.9540584259045467e-05 0.08127600719912718 0.02705517941610137 4.024314679497118e-11 10.395308067160416 0.1267159021253762 DDMIHQLPLLTEK(ub)QYIATIHSR ddPTM_RPMI8226_Bortezomib_2h_R1 2 DDMIHQLPLLTEKQYIATIHSR 22 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 48079100.0 11087800.0 14951400.0 22039900.0 True False 10735823.85815488 20921571.990520958 16266989.007172775 1.0 1.948762597723605 1.5152063988844646 23.35592957086869 -10.135751108877876 4.545266115690923 0.9999302063992407 1.731984498147283 0.7916925295765446 0.17699857731273377 123642421.01911847 19.37183321389286 111736.1803071249 0.06059132085034782 7.31558214254089e-11 10.135751108877876 0.7320542917480423 DDMIHQLPLLTEK(ub)QYIATIHSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDMIHQLPLLTEKQYIATIHSR 22 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 24922200.0 3646800.0 9111400.0 12164000.0 True False 4995120.511064406 8708828.220629403 9291113.72544374 1.0 1.7434670898007318 1.8600379520100716 22.25208805387194 -11.16263801921062 0.33431889047399094 1.0619963697634173e-12 1.8833451527897629 0.9993753270839897 0.009520859428877567 3.158978270677668 0.17013538537044137 2.409835151055279 0.036668033484229715 6.8764134448906424e-12 11.16263801921062 1.8833451527887008 DDMIHQLPLLTEK(ub)QYIATIHSR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DDMIHQLPLLTEKQYIATIHSR 22 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 57695600.0 11087800.0 20846100.0 25761700.0 True False 9219996.972824998 20733797.921673123 31148352.36135731 1.0 2.248785762379736 3.3783473522999956 23.136334846302965 -6.972318589754249 0.19500793342635023 0.28278453305787116 5.375369320212161 0.999995270470036 0.002112461686450497 0.0755573050399217 0.006258373617058827 0.03822532482092892 0.12147595249233836 1.0658139745461378e-07 6.972318589754249 5.09258478715429 DDMIHQLPLLTEK(ub)QYIATIHSR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DDMIHQLPLLTEKQYIATIHSR 22 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 88730900.0 25355900.0 24294600.0 39080400.0 True False 32823712.389511883 22942584.153330233 31968168.19876642 1.0 0.698963721137803 0.9739351789159951 24.9682350823152 -10.389065583401909 7.989234172721228 1.0000021515621598 0.8364494503006425 0.32051451642936424 0.11225662756430321 4.3021255340708996e-06 3.290353356152976e-07 0.10869344224965062 0.03623067075482958 4.082577301208963e-11 10.389065583401909 -0.16355270126151722 DDNMFQIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDNMFQIGK 9 0 P53999 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 0 14006900.0 4497200.0 2071400.0 7438300.0 False True 4354438.847642826 2898520.8222083 5489986.0857832 1.0 0.6656473827339077 1.2607792365151886 22.054055381400897 -6.754223279980726 1.6338873488652266 0.8044072870709491 1.2623799975759507 0.6671082026084114 0.1405376043461833 0.2927163346244159 1.5386139513515806 0.06790806242825793 0.16415937581013434 1.761070410074589e-07 6.754223279980726 0.45797271050500155 DDNMFQIGK(ub)MR ddPTM_RPMI8226_Bortezomib_1h_R1 2 DDNMFQIGKMR 11 1 P53999 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 1 88360950.0 39563300.0 36635400.0 12162250.0 True False 51867869.43154214 31169541.123670734 10903817.03853998 1.0 0.6009412274936391 0.21022295995657567 25.628337773768724 -7.642639623375182 0.34949316111871265 1.0656992519218735 1.240490032611305e-11 0.9991508333777784 0.00939579054817851 0.12320891340948843 0.048358233609955205 0.02753755722021281 0.07381679979251053 2.2769860852077204e-08 7.642639623375182 -1.0656992519094686 down DDNMFQIGK(ub)MR ddPTM_RPMI8226_Bortezomib_2h_R1 3 DDNMFQIGKMR 11 1 P53999 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 1 169723620.0 79391700.0 55494800.0 34837120.0 True False 76871453.94031946 77654163.0415588 25712233.180802032 1.0 1.0101820514783941 0.33448350281970973 26.19594461994803 -6.903481880340221 0.939014754876083 1.025472718041757 0.25832692771351823 0.9882197961947027 0.03431437567781788 0.10888687975133333 0.1633267958523115 0.027217998914117157 0.07213570408793514 1.2488725490369812e-07 6.903481880340221 -0.7671457903282388 down DDNMFQIGK(ub)MR ddPTM_RPMI8226_Bortezomib_8h_R1 2 DDNMFQIGKMR 11 1 P53999 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 1 125497300.0 39239200.0 46396600.0 39861500.0 True False 59528735.16977645 38116764.23170967 31982857.05308391 1.0 0.6403086530059867 0.5372675391450622 25.827082905399724 -13.999999999999998 0.17531820728509115 2.8405671573093842 0.4513349836131988 0.999504538559097 0.004415262091359841 12.147722882779387 0.1326814051703676 7.609196402902756 0.08010822704630229 1.0000000000000041e-14 13.999999999999998 -2.3892321736961852 DDNMFQIGK(ub)MR ddPTM_RPMI8226_Carfilzomib_1h_R1 3 DDNMFQIGKMR 11 1 P53999 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 1 111584000.0 45675800.0 50703900.0 15204300.0 True False 62563377.60208268 48463634.04262477 11613357.48238774 1.0 0.774632634939637 0.18562548774542412 25.89881506557543 -7.081169700655836 0.5563913189042635 1.005899913487667 2.687835888781839e-11 0.9992063856090979 0.009672214587574897 0.07549503134345911 0.036098805743274835 0.010455345672996249 0.04403295297808016 8.295265665056451e-08 7.081169700655836 -1.0058999134607887 down DDNMFQIGK(ub)MR ddPTM_RPMI8226_Carfilzomib_2h_R1 3 DDNMFQIGKMR 11 1 P53999 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 1 202527800.0 79391700.0 106725400.0 16410700.0 True False 66017716.19865347 106150449.08686665 19842101.495496307 1.0 1.6079085312107744 0.3005572236971902 25.976349895382306 -6.780258350958089 1.534605641700885 1.344115502873082 0.29007856215953226 0.7683151540755124 0.2571106291351899 0.2502149195141235 1.1638782319681553 0.13194827314807067 0.31130899029364933 1.6585999541544172e-07 6.780258350958089 -1.0540369407135497 DDNMFQIGK(ub)MR ddPTM_RPMI8226_Carfilzomib_8h_R1 3 DDNMFQIGKMR 11 1 P53999 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 1 153449100.0 48038300.0 72233800.0 33177000.0 True False 62186526.32646006 68213925.53138663 27139126.424767252 1.0 1.096924519843488 0.4364148960868986 25.89009869621272 -6.869602731155768 1.1361292945436003 1.0546930020509895 0.3980122148387525 0.9642884964652219 0.05503375678979305 0.1372398150362672 0.33132745073049125 0.03760052997986562 0.08896431270100567 1.3501974046240636e-07 6.869602731155768 -0.656680787212237 down DDPENDNSELPTAK(ub)EYFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDPENDNSELPTAKEYFR 18 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 12720500.0 3789800.0 5406400.0 3524300.0 True False 4968464.500475407 4599786.193982139 3159639.24347275 1.0 0.925796328733356 0.6359387781014477 22.244368626378165 -6.94542050948364 0.6070503625177271 1.0032207926972627 0.5434958649128808 0.9987910541754673 0.005461615925782103 0.08537860680931345 0.04398757521161975 0.005567217545972708 0.024416433106713414 1.1339123632631691e-07 6.94542050948364 -0.4597249277843819 DDPENDNSELPTAK(ub)EYFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDPENDNSELPTAKEYFR 18 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 19289300.0 6297300.0 5591500.0 7400500.0 True False 6097395.658467743 7824215.109287294 5462087.039758888 1.0 1.2832060682205255 0.8958065616380706 22.539761734473696 -6.710677019578524 1.7923904816764673 1.173979740262756 0.8966809621435659 0.46855682989127656 0.1193279234717071 0.37368727690151393 2.340561337904013 0.05296679249601624 0.1344703886809348 1.9468073643727384e-07 6.710677019578524 -0.27729877811919024 DDPENDNSELPTAK(ub)EYFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDPENDNSELPTAKEYFR 18 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 14148500.0 3789800.0 4499700.0 5859000.0 True False 5190991.475494096 4300888.375481942 4475224.869892707 1.0 0.8285292695597364 0.8621137004403846 22.307578687901056 -10.284059827028539 5.558592540261863 1.0000162110180444 0.8453214850000584 0.9658502798689377 0.013710786493239096 2.754764446370564e-06 3.5479748095973904e-07 0.013276802650697 0.004425137312641541 5.199243684702438e-11 10.284059827028539 -0.15469472601798595 DDPENDNSELPTAK(ub)EYFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDPENDNSELPTAKEYFR 18 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 19273200.0 6297300.0 6450700.0 6525200.0 True False 5236483.967691588 6415948.798736307 7889589.150884022 1.0 1.2252398438192231 1.5066577496583091 22.320167009907973 -6.968116631050775 0.2997791767184949 0.9510644583280745 1.7896483569689166 0.9999637386522454 0.0012480858584296957 0.07691870373202525 0.011205950126231391 0.004673930537957479 0.02524502420468743 1.0761761645688466e-07 6.968116631050775 0.838583898640842 DDPSKPVHLTAFLGYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDPSKPVHLTAFLGYK 16 1 P39023;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 449890000.0 146040000.0 136480000.0 167370000.0 False True 191459854.25337175 116117715.99487339 150052157.92640638 1.0 0.6064859729873553 0.7837264815204144 27.512466675315206 -10.021911211743154 4.647290676037852 1.0000082328007132 0.6951062272385121 0.7977988804979066 0.07235813466000064 99956190.90399419 8.266302067571363 9287.719515785035 0.024770114100110534 9.507991575600788e-11 10.021911211743154 -0.30490200556220104 DDPSKPVHLTAFLGYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDPSKPVHLTAFLGYK 16 1 P39023;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 316774000.0 103040000.0 55484000.0 158250000.0 False True 99769051.60124429 77639050.54523757 116799577.60176252 1.0 0.778187717525314 1.1706994877387993 26.57208902460597 -6.753389050335559 1.6371754843219926 0.8701023046315909 1.171690611216825 0.6634205733466226 0.09322766100250043 0.2941981718593775 1.5524344151074039 0.04496309669364909 0.1087781345765426 1.7644564744388744e-07 6.753389050335559 0.30158830658523417 DDPSKPVHLTAFLGYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DDPSKPVHLTAFLGYK 16 1 P39023;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 440836000.0 95706000.0 202720000.0 142410000.0 False True 145192999.04581705 166543032.14141083 114262601.07947952 1.0 1.1470458853794774 0.7869704588402562 27.113396649861038 -6.795825893021545 1.4727354179944214 1.0815703867192004 0.7824903308871625 0.8196731801679764 0.06277188146711493 0.2268013576144001 0.971522186491632 0.033536608271481506 0.07820587888590584 1.6001994137989607e-07 6.795825893021545 -0.2990800558320379 DDPSKPVHLTAFLGYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDPSKPVHLTAFLGYK 16 1 P39023;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 380233000.0 146040000.0 87103000.0 147090000.0 False True 200034934.58260533 83254501.44889732 112350371.41364022 1.0 0.4161998084115502 0.5616537513713367 27.575676736838098 -10.265030715417097 8.416150464988709 1.0000003333274197 0.4889267798917165 0.9427292342599136 0.05938132355456107 3.713702846791329e-07 3.237202173062728e-08 0.05749575699537028 0.01916523976688076 5.43211911546599e-11 10.265030715417097 -0.5110735534357032 DDPSKPVHLTAFLGYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDPSKPVHLTAFLGYK 16 1 P39023;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 218391000.0 103040000.0 48615000.0 66736000.0 False True 85682325.44597538 48353101.34567803 80690189.04759943 1.0 0.5643299372887088 0.9417366840548277 26.352494300040245 -10.170846870615604 7.678108977131005 1.0000001062454384 0.7530333106717683 0.3634414904170564 0.15407565917679608 2.802018977312287e-07 3.0400112252799984e-08 0.1491831799784534 0.049727705170638466 6.747659037884172e-11 10.170846870615604 -0.24696679557367018 DDPSKPVHLTAFLGYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DDPSKPVHLTAFLGYK 16 1 P39023;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 396396000.0 95706000.0 199880000.0 100810000.0 False True 123893303.64730209 188756502.29135895 82463614.39795001 1.0 1.5235407946559292 0.6656018684650334 26.884522971953487 -6.7415571563637915 1.6811280177932375 1.3109392951616983 0.6649377040840799 0.6118893267174279 0.21996236227516014 0.3149896354481374 1.7485639645792077 0.10348753843997598 0.253503311792708 1.8131880312208382e-07 6.7415571563637915 -0.6460015910776183 DDQLK(ub)VHGF ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDQLKVHGF 9 1 P41567 P41567 EIF1 Eukaryotic translation initiation factor 1 1 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 DDQLK(ub)VHGF ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDQLKVHGF 9 1 P41567 P41567 EIF1 Eukaryotic translation initiation factor 1 1 47715000.0 10623000.0 0.0 37092000.0 True False 10285778.679736225 0.0 27376492.46385203 1.0 0.0 2.661586771042024 23.294147680716065 -6.80492610728591 1.4356956706426565 0.45165689222657024 2.7029646650312533 0.8461851234538678 0.43051767562708804 0.21379780468143025 0.8694295073755539 0.23584943079358744 0.5469427054581657 1.567017666491903e-07 6.80492610728591 2.251307772804683 DDQLK(ub)VHGF ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDQLKVHGF 9 1 P41567 P41567 EIF1 Eukaryotic translation initiation factor 1 1 38558000.0 0.0 6520000.0 32038000.0 True False 0.0 6231924.8412432475 24471284.243321836 0.0 DDQLK(ub)VHGF ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDQLKVHGF 9 1 P41567 P41567 EIF1 Eukaryotic translation initiation factor 1 1 46901000.0 10623000.0 16600000.0 19678000.0 True False 8833495.178693699 16510572.505157975 23792578.819207985 1.0 1.8690871700458171 2.6934501392603285 23.07455295615034 -6.971765732867939 0.21180919994470815 0.5782363917486816 4.007360953552782 0.9999930749959098 0.0018195127371098006 0.07573380945126149 0.00694159776773028 0.02433494024127036 0.08507004827916465 1.0671716197201821e-07 6.971765732867939 3.4291245618041004 DDQLK(ub)VIECNVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDQLKVIECNVR 12 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 4079000.0 4079000.0 0.0 0.0 True False 3391869.2303390345 0.0 0.0 1.0 0.0 0.0 21.69364911883079 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 DDQQVFIQK(ub)VVPITNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDQQVFIQKVVPITNK 16 1 Q9Y597;Q9Y597-2;H0Y5P8 Q9Y597 KCTD3 BTB/POZ domain-containing protein KCTD3 1 15907000.0 4107300.0 5787000.0 6012700.0 True False 5384710.075149782 4923602.157549322 5390563.4818910435 1.0 0.914367178331763 1.0010870421358942 22.36043723825265 -9.914755140116354 4.38486341787845 1.0000006841558784 0.9577271103714812 0.24060016314716814 0.035403236216659834 22808873.059676487 173.13189083197508 169.70622711327843 0.012775058168401736 1.2168718926870336e-10 9.914755140116354 -0.04227357378439722 DDQQVFIQK(ub)VVPITNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDQQVFIQKVVPITNK 16 1 Q9Y597;Q9Y597-2;H0Y5P8 Q9Y597 KCTD3 BTB/POZ domain-containing protein KCTD3 1 28019000.0 9220400.0 7987600.0 10811000.0 True False 8927703.448991781 11177090.334783733 7979274.776952019 1.0 1.2519558247699165 0.8937656612970417 23.08985767536958 -6.7176697120937 1.7674903019803132 1.153670550129799 0.8943898721851999 0.5014900870800538 0.10605619271910834 0.35991786454817287 2.1960985968329334 0.04766506170392157 0.11999584051208805 1.9157123010266717e-07 6.7176697120937 -0.2592806779445991 DDQQVFIQK(ub)VVPITNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDQQVFIQKVVPITNK 16 1 Q9Y597;Q9Y597-2;H0Y5P8 Q9Y597 KCTD3 BTB/POZ domain-containing protein KCTD3 1 14859400.0 4107300.0 5108600.0 5643500.0 True False 5625879.8056089785 4882885.160118911 4310621.531530897 1.0 0.8679327196522569 0.7662128734483851 22.423647299775542 -6.974034871509583 0.12952830215741723 1.1586584390728631 0.47285542756830873 0.9999992291179387 8.383546041459314e-05 0.07501378701916797 0.0038870563159662053 0.006433229134130302 0.013930252522437412 1.0616103121817859e-07 6.974034871509583 -0.6858030115045544 DDQQVFIQK(ub)VVPITNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDQQVFIQKVVPITNK 16 1 Q9Y597;Q9Y597-2;H0Y5P8 Q9Y597 KCTD3 BTB/POZ domain-containing protein KCTD3 1 23611100.0 9220400.0 8262100.0 6128600.0 True False 7667171.1329781795 8217590.427401549 7410061.924555238 1.0 1.0717890972924675 0.9664662228136452 22.870262950803856 -6.723176952675443 1.747686033677138 1.0435265110208463 0.9665981761555577 0.5275332052842218 0.030197987734204394 0.3491923586440323 2.0860468409236095 0.013710119177981355 0.03429217181632738 1.891572742957538e-07 6.723176952675443 -0.0769283348652886 DDQQVFIQK(ub)VVPITNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DDQQVFIQKVVPITNK 16 1 Q9Y597;Q9Y597-2;H0Y5P8 Q9Y597 KCTD3 BTB/POZ domain-containing protein KCTD3 1 23278000.0 10267000.0 13011000.0 0.0 True False 13290833.892826471 12286926.41241181 0.0 1.0 0.924466178081083 0.0 23.6639282891645 -7.090508177711255 1.0011036446462966 1.0025264249570602 1.7729705668828272e-17 0.9892825362233492 0.04706751556917904 0.08446205897225736 0.1613338919718801 0.038607481141996074 0.0683545249200089 8.118799611927206e-08 7.090508177711255 -1.0025264249570602 down DDQQVFIQK(ub)VVPSASQLFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDQQVFIQKVVPSASQLFVR 20 1 M0R2P6;Q8TBC3;M0QZF4;M0R204;M0R0S2 M0R2P6 SHKBP1 SH3KBP1-binding protein 1 1 6713000.0 1280800.0 2025100.0 3407100.0 True False 1240141.7050744733 2833732.990756986 2514678.299190934 1.0 2.285007414202568 2.027734644275931 20.242073549232884 -10.059692904860169 4.997954499241431 0.999976907065274 2.156371029246165 0.9642048794609316 0.10503116852942854 7208073.340889185 14508136.743258426 1190.2270019945795 0.0359549625997282 8.71579677159899e-11 10.059692904860169 1.156394122180891 DDQQVFIQK(ub)VVPSASQLFVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDQQVFIQKVVPSASQLFVR 20 1 M0R2P6;Q8TBC3;M0QZF4;M0R204;M0R0S2 M0R2P6 SHKBP1 SH3KBP1-binding protein 1 1 4041770.0 1280800.0 2144700.0 616270.0 True False 1065041.9490606103 2133146.0754103838 745129.2076894649 1.0 2.002875170590101 0.6996242808526789 20.02247882466716 -6.701183618153607 1.8269882739197387 1.6220273873730073 0.7034550076816038 0.4230880053646692 0.4232349004116139 0.3930407608176878 2.5514668892476804 0.18476857489646645 0.47442311095608874 1.9898318673176488e-07 6.701183618153607 -0.9185723796914035 DDREDKENAFK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDREDKENAFKR 12 3 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 3004790.0 1218300.0 1050500.0 735990.0 True False 1597203.0980339807 893769.4948169292 659836.8149145966 1.0 0.5595841229691343 0.4131201697059058 20.607116344751077 -13.999999999999998 0.1538336301571904 3.1431488312025624 0.25887286456426156 0.9995539519464635 0.005267487445782736 11.974236447085957 0.1237087068252236 7.663660435316877 0.13957546887332034 1.0000000000000041e-14 13.999999999999998 -2.8842759666383007 DDREDKENAFK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDREDKENAFKR 12 3 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 5323700.0 2343800.0 1561500.0 1418400.0 True False 2269397.3519312586 2185015.093114925 1046878.4889121016 1.0 0.962817327364675 0.4613024193498804 21.113877803927878 -6.921777092812058 0.8114392862136856 1.010372939302337 0.37702825553649627 0.9946604330609288 0.017950211823933658 0.0971375065036957 0.1002791507715723 0.015613267827154966 0.04759400530573482 1.1973549313258503e-07 6.921777092812058 -0.6333446837658407 down DDREDKENAFK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDREDKENAFKR 12 3 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 4876100.0 2343800.0 1503600.0 1028700.0 True False 1948973.5479452398 1495499.8083587678 1243796.4138286018 1.0 0.7673268885231616 0.6381802437184995 20.894283079362154 -13.999999999958519 0.07004842803592036 2.3461078544549334 0.1699484192903116 0.9999242500842678 0.0013030164812122508 12.359761103576687 0.07144626375824677 2.7180348770166227 0.4312496897861941 1.0000000000955146e-14 13.999999999958519 -2.176159435164622 DDREQFYK(ub)IAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDREQFYKIAK 11 2 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 1 19976000.0 6991100.0 10138000.0 2846900.0 True False 9165399.801908698 8625449.917614486 2552330.097393118 1.0 0.9410882344508564 0.2784744967548054 23.12776638294812 -6.924350515472888 0.7917992276143706 1.0124580869513844 0.1601473240453367 0.9953063502265704 0.022411749676058496 0.09567940369827625 0.09284416627545977 0.019769060585854214 0.06192167047975593 1.190280954368132e-07 6.924350515472888 -0.8523107629060477 down DDREQFYK(ub)IAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDREQFYKIAK 11 2 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 1 30637700.0 16436000.0 8093300.0 6108400.0 True False 15914248.176611554 11324996.896001955 4508426.791928005 1.0 0.7116262590805759 0.2832949908720058 23.92381566677165 -7.092419056407496 0.37646825580377996 1.0335073814851061 4.560375670293348e-12 0.9998722467299446 0.003328074231538898 0.07563765881632716 0.01755524363787786 0.00642639558636638 0.03572718038618299 8.083155685332132e-08 7.092419056407496 -1.0335073814805458 down DDREQFYK(ub)IAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DDREQFYKIAK 11 2 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 1 46920700.0 18954000.0 9632700.0 18334000.0 True False 28754603.723010205 7913669.424371385 14710276.863922326 1.0 0.2752139970560142 0.5115798849333739 24.777289619803913 -10.17303530893114 5.298615079026614 1.0000251847134622 0.39339694099517786 0.8977682247478872 0.09649596965066341 2.8709672801763184e-05 4.480623210329868e-06 0.09343569068181393 0.031143940285986875 6.713742667582274e-11 10.17303530893114 -0.6066282437182844 DDREQFYK(ub)IAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDREQFYKIAK 11 2 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 1 16459900.0 6991100.0 5986200.0 3482600.0 True False 9575898.597373672 5721709.890283796 2660081.60639842 1.0 0.5975115371264539 0.2777892413280134 23.190976444471012 -7.829034792401757 0.26195494289445165 1.146932876779314 2.6636824583947636e-12 0.9996414970718747 0.005594779884459117 0.11876893386782582 0.040848954832427155 0.049347479381007225 0.08654054069846626 1.4823993217240837e-08 7.829034792401757 -1.1469328767766505 down DDREQFYK(ub)IAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDREQFYKIAK 11 2 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 1 36872000.0 16436000.0 16813000.0 3623000.0 True False 13667262.238257514 16722425.031880781 4380552.549140683 1.0 1.2235387556310457 0.32051426780109654 23.704220942205925 -6.841214709226702 1.2768825028769144 1.1188999712747372 0.29011798224790225 0.9264987669048061 0.10410743664679276 0.1673872123807372 0.5296322928367249 0.06392147565495497 0.14730237748599695 1.4414025657131903e-07 6.841214709226702 -0.8287819890268349 down DDREQFYK(ub)IAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DDREQFYKIAK 11 2 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 1 47735000.0 18954000.0 12898000.0 15883000.0 True False 24536326.63919673 12180214.961746797 12992456.973342326 1.0 0.49641558579061823 0.5295192375123872 24.548415941896362 -10.01381802612884 5.412946405456512 1.0000020476810552 0.5129674116535463 0.9965470133465462 0.013514509226458265 3.646227346813706e-07 6.642586307387056e-08 0.013085427335996413 0.004361789096759295 9.686836596905764e-11 10.01381802612884 -0.48703463602750885 DDTTLNALNTLHESGYDAGK(ub)ALQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDTTLNALNTLHESGYDAGKALQR 24 1 Q9P2R6;A0A590UK57;H7BYW9;A0A590UJ84;B1AKN3;K7EIE3 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 124041300.0 41798000.0 77122000.0 5121300.0 True False 40471145.36906842 107917216.7859169 3779877.8942932556 1.0 2.666522427319209 0.0933968599065686 25.27039034333729 -6.731887095393042 1.7163330686350122 2.000822844236202 0.09441329728510044 0.5679181742420882 0.700473117706362 0.33275558735799354 1.9212038054962486 0.3233048929517603 0.800555883503592 1.8540135532412695e-07 6.731887095393042 -1.9064095469511018 DDTTLNALNTLHESGYDAGK(ub)ALQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DDTTLNALNTLHESGYDAGKALQR 24 1 Q9P2R6;A0A590UK57;H7BYW9;A0A590UJ84;B1AKN3;K7EIE3 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 154031300.0 126644000.0 21739000.0 5648300.0 True False 192128206.91658235 17859505.60241777 4531911.029262167 1.0 0.09295618737633854 0.0235879525551905 27.517494100024898 -13.60921355504863 0.3684452473324479 9.999997863137969 0.016111305851041327 0.9997776505027921 0.006633137102616699 16.866896988198594 0.1962409832852531 118.37511695398487 0.01948958192031156 2.4591580682603268e-14 13.60921355504863 -9.983886557286928 DDTTLNALNTLHESGYDAGK(ub)ALQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDTTLNALNTLHESGYDAGKALQR 24 1 Q9P2R6;A0A590UK57;H7BYW9;A0A590UJ84;B1AKN3;K7EIE3 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 29538600.0 9397900.0 16954000.0 3186700.0 True False 12872557.598698068 16204916.22061932 2434067.092146632 1.0 1.258873079135283 0.18908962523444553 23.61779538974952 -6.842766757681712 1.2693436272270853 1.1377105638535552 0.151900777260636 0.9291278628945482 0.12131775365250909 0.16559216223119108 0.5170541772621914 0.07490373613727294 0.17272707271439153 1.4362605847769216e-07 6.842766757681712 -0.9858097865929192 down DDVAPESGDTTVK(ub)KPESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDVAPESGDTTVKKPESK 18 2 O76021;J3QSV6;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 4601110.0 1417800.0 2640300.0 543010.0 True False 1178963.5191896753 2626076.1798414844 656550.8804054327 1.0 2.227444816652544 0.556888207072508 20.16908764684591 -6.709809422989763 1.796065274134554 1.7547520110746964 0.560862601139616 0.4641525060171715 0.5172526792523648 0.3754387997887098 2.360774614190383 0.22920175306859167 0.5823753141742956 1.9507004179031136e-07 6.709809422989763 -1.1938894099350805 DDVFGYPQQFEDK(ub)PALSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDVFGYPQQFEDKPALSK 18 1 Q93008;Q93008-3 Q93008 USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X 1 69165000.0 19482000.0 27455000.0 22228000.0 True False 25541090.66395638 23358821.0187518 19928059.78603194 1.0 0.9145584785741275 0.7802352706164754 24.606316797000204 -6.964465252150453 0.36711544820469827 1.0106733235989356 0.6794659549548184 0.9999016887411144 0.0008968644986542587 0.07814289628973188 0.015502719405521462 0.0017786310679089464 0.01142595156453229 1.0852623778722105e-07 6.964465252150453 -0.33120736864411715 DDVFGYPQQFEDK(ub)PALSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDVFGYPQQFEDKPALSK 18 1 Q93008;Q93008-3 Q93008 USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X 1 51423000.0 18984000.0 15519000.0 16920000.0 True False 18381363.311316244 21715817.630515866 12488144.410880398 1.0 1.1814040810099655 0.6793916315876438 24.13174043679794 -6.808949608770681 1.4188902741380207 1.098987927200314 0.6708143426846828 0.8570759462845884 0.07846698424676475 0.2082395793034807 0.8264708409144242 0.04348585422967063 0.1006429568107997 1.552567144018198e-07 6.808949608770681 -0.42817358451563126 DDVFGYPQQFEDK(ub)PALSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DDVFGYPQQFEDKPALSK 18 1 Q93008;Q93008-3 Q93008 USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X 1 166687000.0 56720300.0 78927700.0 31039000.0 True False 86048841.90937296 64842435.27006527 24904128.045123033 1.0 0.7535538402522329 0.28941851502606136 26.3586524400581 -6.961203615088737 0.41812973433366163 1.0209333852258464 0.0045843441272309686 0.9998122561266157 0.004036545757256258 0.07927399496345248 0.019563548051832254 0.005997216028486897 0.03865601258529831 1.0934435948145003e-07 6.961203615088737 -1.0163490410986153 down DDVFGYPQQFEDK(ub)PALSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDVFGYPQQFEDKPALSK 18 1 Q93008;Q93008-3 Q93008 USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X 1 61425000.0 19482000.0 21825000.0 20118000.0 True False 26685021.88125389 20860699.33437637 15366542.743215838 1.0 0.7817381386159146 0.5758489841827998 24.669526858523096 -6.9718317024149705 0.2098924208642724 1.1079430173875084 0.24389727694136368 0.999993360037693 0.0004462240026297585 0.07571282538024852 0.00686184553985948 0.006170700597597058 0.02134041080944209 1.0670095281334792e-07 6.9718317024149705 -0.8640457404461448 DDVFGYPQQFEDK(ub)PALSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDVFGYPQQFEDKPALSK 18 1 Q93008;Q93008-3 Q93008 USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X 1 67389000.0 18984000.0 37344000.0 11061000.0 True False 15786037.133796584 37142820.459796384 13373803.959714381 1.0 2.3528907315362075 0.8471919739173922 23.912145712232217 -6.669999306953993 1.9384281945027333 1.8635861439350727 0.8534089064871758 0.27869059142067565 0.5746850644162547 0.46105444394110323 3.3402492489882736 0.238734947954949 0.6375959471189969 2.1379655012593093e-07 6.669999306953993 -1.010177237447897 DDVFGYPQQFEDKPALSK(ub)TEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DDVFGYPQQFEDKPALSKTEDR 22 2 Q93008;Q93008-3 Q93008 USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X 1 29287800.0 16029500.0 5340600.0 7917700.0 True False 21014829.729898818 4543803.297495755 7098452.355941373 1.0 0.21621889665044805 0.33778300596183564 24.32490443148773 -9.93092796157902 5.626413417176522 1.0000006983874268 0.27700095147772413 0.9792372681048482 0.04962833981217134 4.347742540946641e-07 8.259417073998168e-08 0.048052479934703025 0.01601747779878505 1.1723898191058053e-10 9.93092796157902 -0.7229997469097027 DDVFGYPQQFEDKPALSK(ub)TEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DDVFGYPQQFEDKPALSKTEDR 22 2 Q93008;Q93008-3 Q93008 USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X 1 22041900.0 7723500.0 9107600.0 5210800.0 True False 7478321.720130159 12744312.17550657 3845935.159350803 1.0 1.7041674124825907 0.514277842446696 22.834283107122605 -6.746356275348791 1.6632398716983627 1.4158629542089471 0.5125423620797017 0.6331788112507535 0.2958585750768832 0.3064452558938785 1.666731285740297 0.14058578648207423 0.34263227562292997 1.7932619131174855e-07 6.746356275348791 -0.9033205921292454 DDVFGYPQQFEDKPALSK(ub)TEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDVFGYPQQFEDKPALSKTEDR 22 2 Q93008;Q93008-3 Q93008 USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X 1 35682500.0 16029500.0 13282600.0 6370400.0 True False 21956039.330949552 12695730.812315574 4865842.722506316 1.0 0.5782341077527351 0.2216175080196433 24.388114493010622 -7.816021242147139 0.31270172049116385 1.099870159970898 8.236650949496773e-22 0.9992642447174518 0.008629596867071916 0.11654268029959926 0.050976607206668585 0.04166279399085617 0.08273772398943247 1.5274913439813333e-08 7.816021242147139 -1.099870159970898 down DDVFGYPQQFEDKPALSK(ub)TEDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DDVFGYPQQFEDKPALSKTEDR 22 2 Q93008;Q93008-3 Q93008 USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X 1 36610200.0 7723500.0 20015700.0 8871000.0 True False 6422432.459064363 19907871.451294597 10725885.08513028 1.0 3.0997401028635854 1.670065843976638 22.61468838255688 -10.479272918925481 6.204793228165251 0.9991863964659988 2.3849029734200644 0.5557791072964798 0.5836620721107868 0.006572068035594597 0.0005515500132902552 0.5653834516287396 0.18837612375816584 3.3168595427366874e-11 10.479272918925481 1.3857165769540656 DDWNK(ub)VSEHVGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDWNKVSEHVGSR 13 1 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 1 3064530.0 1049800.0 894030.0 1120700.0 True False 1437939.429778275 854528.7984381446 856013.741541007 1.0 0.5942731527780066 0.5953058409928998 20.455571475839267 -10.540298264764399 9.289145080607094 1.0000217492648256 0.5947894968854534 0.9999951278837622 0.0004215931983123347 1.8990586224358617e-07 9.398364630124879e-09 0.00040822768122356507 0.00013606861966150146 2.882051487965342e-11 10.540298264764399 -0.4052322523793722 DDYK(ub)TLVGSENPPLTVIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DDYKTLVGSENPPLTVIR 18 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2;D6R939;E9PDT6 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 1 9087200.0 2236900.0 2640800.0 4209500.0 True False 3063942.3799495343 2524120.7240422033 3215302.797373845 1.0 0.8238146841664097 1.0494005430437643 21.54695773573107 -6.698307043951304 1.8367198122145014 0.890416787012046 1.0487128964975012 0.4096413400192207 0.07439306195500221 0.39904955709003487 2.6159839791710287 0.03232591441563727 0.08331365324657149 2.003055376855922e-07 6.698307043951304 0.15829610948545525 DEAAYGELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DEAAYGELR 9 0 A0A087X1Z3;Q9UL46;H0YM70 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 0 8036070.0 715270.0 3712200.0 3608600.0 False True 937725.8966845328 3158354.230042264 3235216.6881354493 1.0 3.3680996133401964 3.4500664848587754 19.838806749752933 -10.418093012687265 0.664675614647368 2.6117531219318266e-15 3.4373706344472508 0.999880502106195 0.012419784067781795 1.7849303327622423 0.3309812048448152 3.1793419858977368 0.013204467920180027 3.81862478736971e-11 10.418093012687265 3.437370634447248 DEAAYGELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DEAAYGELR 9 0 A0A087X1Z3;Q9UL46;H0YM70 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 0 5401070.0 715270.0 1799200.0 2886600.0 False True 979724.648444947 1719705.394841234 2204844.5313931187 1.0 1.7552946101446056 2.2504736763464352 19.902016811275825 -8.382757412328543 0.13792504215843615 3.8233280528936003e-19 3.2995527791118535 0.9999348703628281 0.004149515857988057 0.11109756445311655 0.03195735088314579 0.3584358130051347 0.3376307549524296 4.142309908411863e-09 8.382757412328543 3.2995527791118535 DEASVYK(ub)ICR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DEASVYKICR 10 1 O60502-2;O60502-4;O60502 O60502-2 MGEA5 Protein O-GlcNAcase 1 5661000.0 1892800.0 1695400.0 2072800.0 True False 2481479.129901276 1442452.928617438 1858326.5397015915 1.0 0.5812875519427904 0.7488785689587983 21.242768890445387 -10.121811686093396 5.193523509107803 1.0000092054592595 0.6650830604504199 0.8418947434135672 0.06841874619519218 7.292846955624714e-06 1.2332566746875723e-06 0.06624798663748324 0.02208205538167626 7.554197132909356e-11 10.121811686093396 -0.33492614500883966 DEASVYK(ub)ICR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DEASVYKICR 10 1 O60502-2;O60502-4;O60502 O60502-2 MGEA5 Protein O-GlcNAcase 1 2271470.0 1391700.0 879770.0 0.0 True False 1347521.2452780658 1231066.748939941 0.0 1.0 0.9135787307649506 0.0 20.361876588287622 -7.101892149971208 0.9881198449614699 1.0004471792438483 4.602737540260321e-18 0.9894734247574183 0.0464171286810186 0.08477746871083097 0.15742489043725968 0.0382770622596995 0.06761605305942844 7.90875004664795e-08 7.101892149971208 -1.0004471792438483 down DEASVYK(ub)ICR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DEASVYKICR 10 1 O60502-2;O60502-4;O60502 O60502-2 MGEA5 Protein O-GlcNAcase 1 49735300.0 3000900.0 6856400.0 39878000.0 True False 4552584.695176814 5632821.8507022895 31996095.820851702 1.0 1.2372799690404268 7.02811654547572 22.118254426323098 -6.9155205268213935 0.8572773308336765 0.850464497766736 7.872111092937054 0.9928437191390008 0.2358027436565496 0.1008799368275724 0.11979747241562962 0.1984878619776784 0.5713373457351806 1.2147292052385917e-07 6.9155205268213935 7.021646595170318 up DEASVYK(ub)ICR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DEASVYKICR 10 1 O60502-2;O60502-4;O60502 O60502-2 MGEA5 Protein O-GlcNAcase 1 7171900.0 1892800.0 1482200.0 3796900.0 True False 2592619.310996684 1416711.503020053 2900150.4196101096 1.0 0.5464402340177837 1.1186179194565982 21.305978951968278 -6.695442788618278 1.8469058052032605 0.7171119245837831 1.116789789986174 0.3960709367097852 0.19161717232601191 0.40508353914283585 2.6829787560225657 0.08286812504508338 0.21433910633381173 2.016309569845244e-07 6.695442788618278 0.3996778654023909 DEASVYK(ub)ICR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DEASVYKICR 10 1 O60502-2;O60502-4;O60502 O60502-2 MGEA5 Protein O-GlcNAcase 1 28077600.0 3000900.0 3678700.0 21398000.0 True False 3884724.2065825406 3473977.111162803 17503783.562020972 1.0 0.8942660859363607 4.50579825779173 21.889380748415547 -6.900154453868846 0.9602761843195358 0.8504814244645762 4.88610044408512 0.9866434223376219 0.19394214561264883 0.11129217457161218 0.17677298115073994 0.1514287484306665 0.39430431150978273 1.258477763168727e-07 6.900154453868846 4.035619019620544 up DECIDPFSK(ub)TGNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DECIDPFSKTGNLR 14 1 A0A0J9YWJ4;K7EJD2;A0A0J9YWB6;A0A0A0MR03;Q9Y5B0-4;Q9Y5B0 A0A0J9YWJ4 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 1 42712800.0 3835600.0 7411300.0 31465900.0 True False 4965259.810979367 6998854.639943711 25739429.06739864 1.0 1.4095646363695982 5.183903772866559 22.243437779163372 -6.927564089375049 0.7665230506370024 0.9371191401560741 5.912784930802201 0.9960374319992686 0.11854626317460958 0.09392267625349204 0.08402238330004262 0.10647559031512367 0.34620009680386393 1.1815059433824954e-07 6.927564089375049 4.975665790646127 up DEDDTK(ub)ADSWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DEDDTKADSWK 11 1 J3KTJ4;J3QR30;K7EKV6;A8MT25;Q96C03-2;Q96C03;Q96C03-3 J3KTJ4 MIEF2 Mitochondrial dynamics protein MID49 1 4119400.0 1278900.0 1358100.0 1482400.0 True False 1676650.2848852156 1155476.7738323368 1329015.4681848902 1.0 0.6891578907353607 0.7926611053991354 20.67715037279069 -10.777188552832314 10.11015061645281 1.0014480854918397 0.740909498067248 0.8931025614515625 0.04225501044400024 0.0013853515574714494 3.0530831844631427e-05 0.04109525368410206 0.013637745978619446 1.6703652528518793e-11 10.777188552832314 -0.2605385874245917 DEDDTK(ub)ADSWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DEDDTKADSWK 11 1 J3KTJ4;J3QR30;K7EKV6;A8MT25;Q96C03-2;Q96C03;Q96C03-3 J3KTJ4 MIEF2 Mitochondrial dynamics protein MID49 1 5244300.0 1245800.0 1445300.0 2553200.0 True False 1206252.760916443 2022415.8271399292 1884440.325641833 1.0 1.6766103197172466 1.562226746084412 20.20210081380305 -10.196053565850695 4.547601376041297 0.9998632411370445 1.6194185329084836 0.9750625143896606 0.04669689841882744 5380670.66025113 12256722.408603765 4602.434680931369 0.015985589061236653 6.367169834368884e-11 10.196053565850695 0.6195552917714391 DEDDTK(ub)ADSWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DEDDTKADSWK 11 1 J3KTJ4;J3QR30;K7EKV6;A8MT25;Q96C03-2;Q96C03;Q96C03-3 J3KTJ4 MIEF2 Mitochondrial dynamics protein MID49 1 3403700.0 1278900.0 1044900.0 1079900.0 True False 1751743.890972978 998732.8629777733 824849.8612386307 1.0 0.5701363470564428 0.47087354806214343 20.74036043431358 -13.999999999999998 0.20592405618002468 3.4453524737704426 0.4100443229376109 0.99948813175442 0.005195487666664556 12.65436315583005 0.143858784730634 12.495981515470273 0.06052354575709149 1.0000000000000041e-14 13.999999999999998 -3.0353081508328317 DEDDTK(ub)ADSWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DEDDTKADSWK 11 1 J3KTJ4;J3QR30;K7EKV6;A8MT25;Q96C03-2;Q96C03;Q96C03-3 J3KTJ4 MIEF2 Mitochondrial dynamics protein MID49 1 5174100.0 1245800.0 2231200.0 1697100.0 True False 1035937.8982977122 2219180.0827414733 2051955.7634961791 1.0 2.142194128034223 1.9807710161661443 19.982506089237326 -10.107015998738335 4.886310699753091 0.9999572775288077 2.0614825719235483 0.9829510030973656 0.06590070951018606 3.300698690986991e-05 6.031952615696248e-06 0.06381083408851866 0.02126936252919451 7.815990111568874e-11 10.107015998738335 1.0615252943947406 DEDFK(ub)QYVNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DEDFKQYVNK 10 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 2480800.0 0.0 1275100.0 1205700.0 True False 0.0 1084860.0503008708 1080945.7298910685 0.0 DEDFK(ub)QYVNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DEDFKQYVNK 10 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 4086770.0 948370.0 1431100.0 1707300.0 True False 918264.5134614927 2002545.6930879075 1260106.91209788 1.0 2.180793947420559 1.3722700742815128 19.808550267826035 -10.25630198354608 5.239471512030885 0.999901468692722 1.7765320108511715 0.5515505165229311 0.3300784890087147 0.00037995783382136834 5.393196100200386e-05 0.3196372141898539 0.10653237423926941 5.542401920054579e-11 10.25630198354608 0.7766305421584495 DEDFK(ub)QYVNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DEDFKQYVNK 10 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 1176200.0 0.0 1176200.0 0.0 True False 0.0 1124231.5948267342 0.0 0.0 DEDFK(ub)QYVNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DEDFKQYVNK 10 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 3474940.0 948370.0 1607300.0 919270.0 True False 788611.6749145944 1598641.1558759278 1111485.1067757546 1.0 2.027158875182844 1.4094200506175958 19.58895554326031 -10.675043602865747 6.540489959752704 0.9946182266347364 1.718289462900205 0.6432035629750863 0.25219081908191876 0.019808856598509655 0.000984177964431279 0.24440353535823425 0.08139423686422326 2.1132768576497926e-11 10.675043602865747 0.7236712362654686 DEDFK(ub)QYVNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DEDFKQYVNK 10 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 11339600.0 2055200.0 2660900.0 6623500.0 True False 2660496.9140485995 2512818.5758809145 5418090.96284914 1.0 0.944492197157652 2.0364958644526987 21.34326429944179 -6.894928649396327 0.9927848849119064 0.9480680589892303 2.1400080707316267 0.9838694761884204 0.063782879554492 0.11523468472741435 0.1992239234485332 0.048608151203209535 0.12353912286805445 1.2737123230907984e-07 6.894928649396327 1.1919400117423964 up DEDFVKPK(ub)GAFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DEDFVKPKGAFK 12 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 11742400.0 3245400.0 5411100.0 3085900.0 True False 4923509.070521118 4445446.927882735 2475970.512401984 1.0 0.9029021505209122 0.5028873669039307 22.231255485323175 -6.944197553736783 0.6192822772343948 1.0043802674779672 0.38024324580893837 0.9986636196847922 0.007864712607132467 0.0859027883186188 0.04627369207394311 0.007925559375424364 0.033844248709403016 1.1371099147248522e-07 6.944197553736783 -0.6241370216690287 DEDFVKPK(ub)GAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DEDFVKPKGAFK 12 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 5924000.0 2755100.0 1648400.0 1520500.0 True False 3773734.923777978 1575568.2374701512 1161389.2156804674 1.0 0.4175089849429094 0.30775590738041886 21.84756165745017 -13.999999999999998 0.23470498596316872 4.758977160988451 0.2567270552789751 0.9995165678715465 0.006679247012770463 13.442382813686834 0.15336367369665344 23.61040055817208 0.05535022382860713 1.0000000000000041e-14 13.999999999999998 -4.502250105709476 DEDK(ub)DEDEKEKAACSAAAMEEDSEASSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DEDKDEDEKEKAACSAAAMEEDSEASSSR 29 3 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 5745530.0 2037400.0 2954600.0 753530.0 True False 2671051.130209664 2513785.1969405934 675561.9439701559 1.0 0.9411220805583284 0.2529198847335909 21.348976162142534 -6.9237781195254575 0.7962175380256352 1.0132189894932317 0.13169312907814607 0.9951673093270581 0.023577027421258497 0.09599989935004191 0.09447095386121522 0.0207314784726506 0.0645314579238233 1.191850767482584e-07 6.9237781195254575 -0.8815258604150857 down DEEGNEIK(ub)ESNAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DEEGNEIKESNAR 13 1 Q8WVC0 Q8WVC0 LEO1 RNA polymerase-associated protein LEO1 1 41534600.0 4564800.0 25962100.0 11007700.0 True False 5984497.005586077 22088655.87947317 9868728.797314372 1.0 3.6909795190565005 1.649048999122676 22.512798563687316 -6.576004782307835 2.2825386201479385 2.83681078596009 1.653731191166422 0.0 1.1702045075405219 0.7112961226365951 6.964610899248084 0.43155986415462433 1.3095549731020322 2.654576330494116e-07 6.576004782307835 -1.183079594793668 DEEGNEIK(ub)ESNAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DEEGNEIKESNAR 13 1 Q8WVC0 Q8WVC0 LEO1 RNA polymerase-associated protein LEO1 1 50439700.0 28735500.0 5796900.0 15907300.0 True False 27823307.281517453 8111632.400434144 11740700.92122918 1.0 0.2915409127448541 0.4219735922274174 24.729790583554347 -10.016088518369974 6.117728042682041 1.0000006152788794 0.3567572524995606 0.9700846601277849 0.0532489184194992 4.468020465739766e-07 7.189566412084374e-08 0.05155809311028294 0.01718601452017195 9.636325949710806e-11 10.016088518369974 -0.6432433627793188 DEEGNEIK(ub)ESNAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DEEGNEIKESNAR 13 1 Q8WVC0 Q8WVC0 LEO1 RNA polymerase-associated protein LEO1 1 34600200.0 29568600.0 2071400.0 2960200.0 True False 44857727.95421546 1701742.4860779317 2375115.172498249 1.0 0.037936439576583866 0.052947736785118424 25.418853213922464 -10.682177341615594 3.015051513614996 1.1050850629135531 0.04544208702255899 0.9998145556923429 0.006128340083718228 8944107.570053052 8906816.68788907 7210169.737401174 0.0022665079917330386 2.078847628471908e-11 10.682177341615594 -1.0596429758909942 DEEGNEIK(ub)ESNAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DEEGNEIKESNAR 13 1 Q8WVC0 Q8WVC0 LEO1 RNA polymerase-associated protein LEO1 1 35586800.0 4564800.0 18789200.0 12232800.0 True False 6252529.919081595 17959031.016424473 9343664.582424236 1.0 2.8722822999401805 1.4943814269339288 22.576008625210207 -6.567504638468488 2.3166078244623387 2.2844342763112495 1.4970856480764598 0.0 0.8159471459857346 0.7377476470291462 7.429280764443865 0.2981470365283703 0.9153274156640213 2.707044291265959e-07 6.567504638468488 -0.7873486282347897 DEEGNEIK(ub)ESNAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DEEGNEIKESNAR 13 1 Q8WVC0 Q8WVC0 LEO1 RNA polymerase-associated protein LEO1 1 68511900.0 28735500.0 32387600.0 7388800.0 True False 23894841.44849406 32213121.570364766 8933763.918048771 1.0 1.3481203313192502 0.3738783509949512 24.510195858988624 -6.810074798180526 1.4141570543222481 1.1897031742412683 0.3567939204256724 0.8600479398030513 0.15079816798724097 0.20669149799318934 0.8146545473354591 0.08384627785765873 0.19395267933120183 1.5485498904731318e-07 6.810074798180526 -0.8329092538155959 down DEEQTAESIK(ub)NQMTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DEEQTAESIKNQMTVK 16 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 20433000.0 6244000.0 7229100.0 6959900.0 True False 5192162.656101236 7190155.403436005 8415182.911058318 1.0 1.3848093520311726 1.6207471661485329 22.307904149016178 -9.620119025792958 0.09490525848881112 1.2315038489909874e-16 2.3527413874232472 0.9999529177058679 0.0017554536630270466 1.1216363165416776 0.03962881607163576 0.6281834401888879 0.35086080239602513 2.3981755681213954e-10 9.620119025792958 2.3527413874232472 DEFEGLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DEFEGLFK 8 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 14938800.0 1078600.0 5831200.0 8029000.0 False True 1414055.0451772572 4961207.689839571 7198236.09960637 1.0 3.5084968628061186 5.090492144670396 20.431406850616156 -8.353812833699923 0.26726943824563293 4.381705075198354e-15 6.222941003537757 0.9992223091923504 0.04696620234695992 0.11701681182495369 0.06694723465203205 0.5712540231038769 0.5521098045792606 4.427791541575692e-09 8.353812833699923 6.222941003537753 DEFEGLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DEFEGLFK 8 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 11216900.0 4292900.0 1269300.0 5654700.0 False True 4156624.239314654 1776138.1093120566 4173564.432636251 1.0 0.4273030245343772 1.0040754690215612 21.986980902905902 -10.91969149079094 10.65034552132169 1.0396716179434364 0.715689246778049 0.2447007729470091 0.2354663644485562 0.12995648612271696 0.0009799301812541768 0.13357894401221382 0.07599644234177205 1.2031187890653039e-11 10.91969149079094 -0.3239823711653874 DEFEGLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DEFEGLFK 8 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 13531000.0 1078600.0 5900800.0 6551600.0 False True 1477387.5680690082 5640083.144663836 5004247.014437455 1.0 3.817605661888438 3.387226969141322 20.494616912139048 -9.84969445951316 10.545014247427542 1.000000004122544 3.6024163020155964 0.9799002293792007 0.17570136556608273 0.0 0.0 0.17012211568583543 0.05670737189527847 1.413531661013015e-10 9.84969445951316 2.6024162978930523 DEFEGLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DEFEGLFK 8 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 6263570.0 4292900.0 785870.0 1184800.0 False True 3569736.557715722 781636.3623270191 1432536.2021037485 1.0 0.21896191769041606 0.40130025814017767 21.76738617834018 -10.698391446393689 10.067699515430236 1.000634252642804 0.31013108798984795 0.9502141849124901 0.07443931577463302 0.001060479239322219 3.176983958715199e-05 0.07212621948328371 0.024025185858185725 2.002666133275823e-11 10.698391446393689 -0.690503164652956 DEFEGLFK(ub)QPAENVNQYLTDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DEFEGLFKQPAENVNQYLTDPK 22 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 74697000.0 25499000.0 26250000.0 22948000.0 True False 24689548.202446923 36731761.89194157 16937230.37475669 1.0 1.4877454050901253 0.6860081130637329 24.557397100852093 -6.742053764496034 1.679284465262082 1.2895191123059644 0.6853360261344924 0.6140582065819576 0.20492299360837407 0.31412502611387005 1.740121114932279 0.09650945331936012 0.23628388612910645 1.8111158674371927e-07 6.742053764496034 -0.604183086171472 DEFEGLFK(ub)QPAENVNQYLTDPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DEFEGLFKQPAENVNQYLTDPK 22 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 118504000.0 43543000.0 33961000.0 41000000.0 True False 66057914.41970217 27900394.211495917 32896332.02906166 1.0 0.4223626261378675 0.49799228931227246 25.97722808579001 -10.585047368614784 6.441639053306219 1.001146241004847 0.46017745772549024 0.9854923576880638 0.030875680699308593 0.0005091971477897699 3.280100718278602e-05 0.02995004236876612 0.009965083095936663 2.5998759785349583e-11 10.585047368614784 -0.5409687832793568 DEFEGLFK(ub)QPAENVNQYLTDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DEFEGLFKQPAENVNQYLTDPK 22 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 13646900.0 5800700.0 2450800.0 5395400.0 True False 7945375.54802327 2342515.5522881835 4121117.641751004 1.0 0.2948275431576016 0.5186812903735302 22.921683981278854 -10.256523597956653 5.083143029037783 1.0000986360974145 0.4067544167656453 0.9035156942650044 0.09138790961565292 0.00010217209624084629 1.4943914386057149e-05 0.08850055529825393 0.029495320998726683 5.5395744312122105e-11 10.256523597956653 -0.5933442193317692 DEFEGLFK(ub)QPAENVNQYLTDPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DEFEGLFKQPAENVNQYLTDPK 22 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 74938000.0 25499000.0 26147000.0 23292000.0 True False 21203548.29723339 26006140.921226878 28162249.509959947 1.0 1.226499478137823 1.3281856939781402 24.33780237628637 -13.591260240274359 0.11180112968801442 1.2026240432381999e-13 1.5136328528992689 0.9997443704245246 0.00219317234963793 10.477639693501152 0.09802738926616555 2.424862685525798 0.16041608324322995 2.5629477929298688e-14 13.591260240274359 1.5136328528991485 DEFEGLFK(ub)QPAENVNQYLTDPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DEFEGLFKQPAENVNQYLTDPK 22 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 126704000.0 43543000.0 34473000.0 48688000.0 True False 56367271.86084967 32554547.24579752 39827283.58106723 1.0 0.577543424953453 0.7065675216531027 25.74835440788246 -10.696594221473056 10.05422153020141 1.000318644785042 0.6420554733032792 0.91120517631548 0.05267386690627612 0.0003765436612973646 1.136291700290664e-05 0.05104387549551135 0.0170004174423628 2.0109708647905272e-11 10.696594221473056 -0.3582631714817629 DEFLIQASPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DEFLIQASPR 10 0 P51149;C9J592 P51149 RAB7A Ras-related protein Rab-7a 0 8758900.0 1889900.0 2230200.0 4638800.0 False True 2477677.201817633 1897462.8532515108 4158821.474511649 1.0 0.7658232686080031 1.6785162617070224 21.240556811010983 -6.838621236640414 1.2887127384088441 0.8753908140231154 1.707738964162968 0.9220723348955991 0.10804553417860296 0.1704118849418946 0.5503471223814347 0.06575498150371499 0.15144130851258533 1.4500359291325467e-07 6.838621236640414 0.8323481501398527 DEFNK(ub)QDHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DEFNKQDHR 9 1 C4B7M2;Q96JI7-2;Q96JI7-3;Q96JI7 C4B7M2 SPG11 Spatacsin 1 1461820.0 256120.0 406180.0 799520.0 True False 335775.80026960844 345579.5272772397 716793.3399373867 1.0 1.0291972411345887 2.134737939309037 18.35713873184368 -6.912568426310088 0.8780878214794852 0.9684864132010104 2.285733358472474 0.9918544388130437 0.047669095320815806 0.10274418854549901 0.12974611889620744 0.03952960040224946 0.11115879459980026 1.2230144088965177e-07 6.912568426310088 1.3172469452714637 up DEFNK(ub)QDHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DEFNKQDHR 9 1 C4B7M2;Q96JI7-2;Q96JI7-3;Q96JI7 C4B7M2 SPG11 Spatacsin 1 963240.0 154270.0 299390.0 509580.0 True False 149372.7832931287 418937.9882982244 376105.7109276852 1.0 2.804647400029373 2.517899865262713 17.188557777952024 -10.2224007734745 5.044678070746495 0.999801526098836 2.6612736326472435 0.9781434871011737 0.11706419086738591 0.000261343899357965 4.028417862655994e-05 0.11335984101346858 0.03778230513828855 5.992378353454228e-11 10.2224007734745 1.6614721065484075 DEFNK(ub)QDHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DEFNKQDHR 9 1 C4B7M2;Q96JI7-2;Q96JI7-3;Q96JI7 C4B7M2 SPG11 Spatacsin 1 915240.0 256120.0 197810.0 461310.0 True False 350814.48538275075 189070.10012980495 352358.0789776768 1.0 0.5389461040171215 1.0044000281038623 18.42034879336657 -10.868605990569414 10.976964048439719 1.008246122531689 0.7716730660608064 0.24291074089390652 0.1900207687981086 0.03808047570901313 0.00045582159246158156 0.18270640883401537 0.06132893941571702 1.3532997744363923e-11 10.868605990569414 -0.23657305647088256 DEGGK(ub)AFFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DEGGKAFFK 9 1 P05141;P12236 P05141;P12236 SLC25A5;SLC25A6 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed;ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed 1 7748800.0 1823200.0 3131100.0 2794500.0 True False 1516071.5814547974 3114232.1428253124 3378817.029691869 1.0 2.054145847016634 2.2286658961377084 20.5319064414162 -10.719861983517564 0.35342067677425487 1.9156208648254567e-13 2.2583797009445705 0.9992610848371694 0.014753854162342884 2.3412541716894117 0.17214750323645706 2.057564956138794 0.05125638664264451 1.906066359500768e-11 10.719861983517564 2.258379700944379 DEGK(ub)TIAIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DEGKTIAIGK 10 1 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 1 5538400.0 1866900.0 2255000.0 1416500.0 True False 2447523.979085319 1918562.7899211529 1269934.1680274522 1.0 0.7838790574947306 0.5188648523484733 21.22289156371413 -6.968389398209742 0.294121332331371 1.0492946159610363 0.24521402310355306 0.999966952734045 0.001131096766982013 0.07682881950522469 0.010890833824908339 0.004530062873777596 0.023920377354100842 1.075500463257928e-07 6.968389398209742 -0.8040805928574832 DEGK(ub)TIAIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DEGKTIAIGK 10 1 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 1 10575100.0 2958800.0 4714200.0 2902100.0 True False 2864874.513565238 6596604.644228229 2141952.948866197 1.0 2.302580658591912 0.7476603036970754 21.450040517164304 -6.684522861923746 1.8863308473547284 1.8208024081216478 0.753423346798421 0.34477206538893324 0.5515284869436875 0.4285189972872942 2.951889952642548 0.23430844928559602 0.61429937848508 2.06765053477759e-07 6.684522861923746 -1.0673790613232268 DEGK(ub)TIAIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DEGKTIAIGK 10 1 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 1 4571900.0 1866900.0 1650000.0 1055000.0 True False 2557143.381075501 1577097.5441796589 805830.7284070343 1.0 0.6167419300189387 0.3151292705644501 21.28610162523702 -7.779038838146725 0.23772725770459963 1.1709289065020518 1.3242378289939846e-15 0.9997831363066155 0.004127168776712474 0.12450128873823606 0.03414368466221348 0.04883173973757941 0.08547763787750792 1.6632639011259213e-08 7.779038838146725 -1.1709289065020505 down DEGK(ub)TIAIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DEGKTIAIGK 10 1 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 1 9694100.0 2958800.0 5098800.0 1636500.0 True False 2460373.2970647556 5071331.75236744 1978684.5836789212 1.0 2.0612041914198866 0.8042212887123703 21.23044579259858 -6.682916534750164 1.89110901304331 1.6697002577956637 0.8088604110539809 0.3374571010512556 0.44948639005893104 0.4322227287057268 2.9909087192483486 0.19052523029794738 0.5007041974105384 2.0753123247736376e-07 6.682916534750164 -0.8608398467416828 DEGK(ub)TIAIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DEGKTIAIGK 10 1 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 1 8737300.0 3264300.0 2718000.0 2755000.0 True False 4225700.698972767 2566740.910685978 2253618.268687158 1.0 0.6074119048019495 0.533312325985367 22.01075915595356 -13.999999999999996 0.2344599195511497 3.5305452033672196 0.498780004056513 0.999516197990108 0.004504234203610529 13.434373811294373 0.15328613126245286 15.866252077209637 0.03742535430569705 1.0000000000000082e-14 13.999999999999996 -3.0317651993107066 DEILPTTPISEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DEILPTTPISEQK 13 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 0 34456500.0 8913500.0 5558000.0 19985000.0 False True 8630545.821503228 7777338.384587097 14750328.962851368 1.0 0.9011409643651572 1.709084137656803 23.041020371958407 -6.876292021678029 1.1003305470032945 0.9412832126202747 1.7624089307154631 0.97056662419578 0.06173424633297889 0.13096237734840446 0.29260020306876094 0.043355277318423514 0.1039198963391492 1.3295601147914942e-07 6.876292021678029 0.8211257180951884 DEILPTTPISEQK(ub)GGKPEPPAMPQPVPTA ddPTM_RPMI8226_Bortezomib_1h_R1 1 DEILPTTPISEQKGGKPEPPAMPQPVPTA 29 2 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2 P23396 RPS3 40S ribosomal protein S3 1 85267000.0 15311000.0 28091000.0 41865000.0 True False 20072869.271934897 23899932.29786039 37533211.39743688 1.0 1.1906584940139249 1.869847847308723 24.258743518506616 -6.947538827444854 0.5852393581912404 0.9920307263568826 2.102373192450832 0.9989937257826371 0.011842266430598289 0.08448931925562372 0.040170221130786804 0.012338376666119269 0.05681981633816936 1.1283950505559329e-07 6.947538827444854 1.1103424660939496 DEILPTTPISEQK(ub)GGKPEPPAMPQPVPTA ddPTM_RPMI8226_Bortezomib_2h_R1 1 DEILPTTPISEQKGGKPEPPAMPQPVPTA 29 2 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2 P23396 RPS3 40S ribosomal protein S3 1 86084000.0 24824000.0 28121000.0 33139000.0 True False 24035975.70797058 39349861.94907769 24458901.75131001 1.0 1.6371235529260777 1.0175955429676684 24.51869203313271 -10.266114967137087 4.105795126183907 0.9996829536645462 1.3273595479670222 0.27128445166086246 0.25292125102658175 34692932.76415406 44149338.901729815 80466.57904172584 0.08658167834452359 5.4185743003938867e-11 10.266114967137087 0.327676594302476 DEILPTTPISEQK(ub)GGKPEPPAMPQPVPTA ddPTM_RPMI8226_Bortezomib_8h_R1 1 DEILPTTPISEQKGGKPEPPAMPQPVPTA 29 2 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2 P23396 RPS3 40S ribosomal protein S3 1 160864000.0 56557000.0 36234000.0 68073000.0 True False 85801103.87054378 29767759.60246586 54618341.71254413 1.0 0.34693912152201783 0.6365692193768506 26.354492872988978 -10.454644509658523 6.146864670064845 1.0002258642144537 0.4917541704495528 0.8041447454891999 0.11824099231611701 0.000366150395527148 3.2485307060371336e-05 0.11453604664624123 0.038162116173280004 3.5103909830014464e-11 10.454644509658523 -0.508471693764901 DEILPTTPISEQK(ub)GGKPEPPAMPQPVPTA ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DEILPTTPISEQKGGKPEPPAMPQPVPTA 29 2 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2 P23396 RPS3 40S ribosomal protein S3 1 95647000.0 15311000.0 24629000.0 55707000.0 True False 20971890.464217115 23540809.342788346 42550153.92167834 1.0 1.122493433911187 2.028913606728908 24.321953580029508 -6.931577282123373 0.7337299608238388 0.9869913035360551 2.2226986183141806 0.9968392901266123 0.025799189702719275 0.09182689599855119 0.07372826366494167 0.023728856417275016 0.08131558184534722 1.1706382702669193e-07 6.931577282123373 1.2357073147781255 up DEILPTTPISEQK(ub)GGKPEPPAMPQPVPTA ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DEILPTTPISEQKGGKPEPPAMPQPVPTA 29 2 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2 P23396 RPS3 40S ribosomal protein S3 1 96780000.0 24824000.0 33893000.0 38063000.0 True False 20642255.889663167 33710411.68176621 46021797.31657246 1.0 1.633077889449431 2.229494565059547 24.299097308566985 -6.971846502411209 0.2094413352634023 0.685507033995258 3.1937046227416435 0.9999934269075886 0.0012870512322847067 0.07570796599779019 0.006843146679384757 0.01793940142240726 0.061883338969658294 1.066973166934831e-07 6.971846502411209 2.5081975887463854 DEILPTTPISEQK(ub)GGKPEPPAMPQPVPTA ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DEILPTTPISEQKGGKPEPPAMPQPVPTA 29 2 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2 P23396 RPS3 40S ribosomal protein S3 1 226941000.0 56557000.0 44894000.0 125490000.0 True False 73214151.40514131 42395609.43500229 102652107.63613474 1.0 0.5790630447985381 1.402080139781914 26.125619195081427 -6.767701269825354 1.5834307684428375 0.7578461668021441 1.4062910332950502 0.7215922185880983 0.177301295701836 0.27018099904705484 1.3365685337863058 0.08828125662767929 0.21057712930664887 1.7072563242846342e-07 6.767701269825354 0.6484448664929061 DEK(ub)DSQGENMFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DEKDSQGENMFLR 13 1 Q8N1F7;H3BVG0;Q8N1F7-2 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 6483900.0 1853000.0 2497800.0 2133100.0 True False 2429300.944477526 2125137.9763481393 1912387.274140033 1.0 0.8747940353702025 0.7872171121850584 21.212109793020225 -6.974954624847291 0.07314839685033356 1.3507693150796496 0.30905096946920585 0.9999999262038646 2.300748208642027e-05 0.07472579113990943 0.0021145273092384306 0.011779511049121448 0.01823063864983566 1.0593644019472795e-07 6.974954624847291 -1.0417183456104437 DEK(ub)DSQGENMFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DEKDSQGENMFLR 13 1 Q8N1F7;H3BVG0;Q8N1F7-2 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 5058290.0 944890.0 1645300.0 2468100.0 True False 914894.9841566366 2302276.8701261505 1821630.5685871132 1.0 2.51643840002951 1.9910815996726865 19.80324662818172 -9.915438924227121 6.014761793675412 0.9999996243935807 2.2537599998515314 0.8836369660347382 0.21447601563078061 1.0807501191950775e-06 1.94986938098972e-07 0.20766557105741232 0.06922183639135197 1.214957470555895e-10 9.915438924227121 1.2537603754579507 DEK(ub)DSQGENMFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DEKDSQGENMFLR 13 1 Q8N1F7;H3BVG0;Q8N1F7-2 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 6687900.0 1853000.0 1804600.0 3030300.0 True False 2538104.175442124 1724866.8049858229 2314605.5509875226 1.0 0.679588655845996 0.9119426906834236 21.275319854543117 -10.488171086558078 5.153459703463744 1.000470369396424 0.7957656732647063 0.5074228589846416 0.09485813750477323 0.0005138067166948916 5.1029979982641736e-05 0.09205465629650784 0.03061533223401818 3.249592572757587e-11 10.488171086558078 -0.20470469613171782 DEK(ub)DSQGENMFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DEKDSQGENMFLR 13 1 Q8N1F7;H3BVG0;Q8N1F7-2 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 5165690.0 944890.0 2092900.0 2127900.0 True False 785717.9007244543 2081625.1322918779 2572834.0517020333 1.0 2.6493288881067367 3.27450100007879 19.583651903615998 -9.552843932800494 0.27994384349957147 3.232829291858121e-10 3.565877488776964 0.9988686706352056 0.03227051637673559 0.9406034653821812 0.11389350679611583 1.0835718014107891 0.23873828272448866 2.7999873367325866e-10 9.552843932800494 3.5658774884536815 DELHIVEAEAMNYEGSPIK ddPTM_RPMI8226_Bortezomib_1h_R1 2 DELHIVEAEAMNYEGSPIK 19 0 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 0 56588100.0 3855300.0 36556700.0 16176100.0 False True 5054335.634778302 31102582.85690054 14502352.344107915 1.0 6.153644139278612 2.869289535170339 22.26909003941464 -9.480701998294785 9.50290738988444 1.0000112206729752 4.51146683722426 0.6038204689761328 1.3408321524199822 0.0 0.0 1.29825512974314 0.43275171636281057 3.305963099127168e-10 9.480701998294785 3.511455616551285 DELHIVEAEAMNYEGSPIK ddPTM_RPMI8226_Bortezomib_2h_R1 2 DELHIVEAEAMNYEGSPIK 19 0 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 0 151876500.0 45754700.0 24256800.0 81865000.0 False True 44302242.0933565 33942666.737540886 60422100.60264326 1.0 0.7661613754449434 1.3638610090053225 25.40087637823142 -6.800598217734551 1.4534465389768434 0.8710738422153712 1.3722349266939395 0.8338869646384532 0.10023232923492195 0.21992090955056853 0.9171380363838905 0.0542496715955393 0.12612030351163586 1.582711588577787e-07 6.800598217734551 0.5011610844785683 DELHIVEAEAMNYEGSPIK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DELHIVEAEAMNYEGSPIK 19 0 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 0 74049700.0 3855300.0 25453800.0 44740600.0 False True 5280708.595565033 24329166.951539516 34173791.741580755 1.0 4.607178470702246 6.471440550664238 22.33230010093753 -8.655668942641487 0.3293998473772356 1.6993357075677333e-22 7.21688991326404 0.9982565366705796 0.09483220090694622 0.2525951798961469 0.10177714993217833 0.8614468204785155 0.558107449386052 2.2096885096333342e-09 8.655668942641487 7.21688991326404 DELHIVEAEAMNYEGSPIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DELHIVEAEAMNYEGSPIK 19 0 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 0 43961000.0 29891000.0 7576800.0 6493200.0 False True 24855690.895823468 7535982.274522949 7850898.098835311 1.0 0.30318941067090716 0.3158591781552331 24.567072869609344 -10.029980225847353 5.414746512622974 1.0000038613319109 0.30952429441225215 0.9997475399675733 0.00517241091892312 2.4111392233636325e-07 4.3187215536245356e-08 0.00500819338394465 0.0016693884453118431 9.332967943904059e-11 10.029980225847353 -0.6904795669196587 DELK(ub)SFILQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DELKSFILQK 10 1 Q9H467 Q9H467 CUEDC2 CUE domain-containing protein 2 1 16212400.0 4419600.0 5274600.0 6518200.0 True False 4279302.2171667265 7380775.286675618 4810887.878191524 1.0 1.7247614008347227 1.1242225096634455 22.028944139337522 -10.24180702274652 4.443534493159747 0.999818526748776 1.4244919552546715 0.39982684779150646 0.24516897569668009 0.00044095356160502757 7.523941345050065e-05 0.23748448215601867 0.07912794665401096 5.730506074803224e-11 10.24180702274652 0.4246734285058955 DELK(ub)SFILQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DELKSFILQK 10 1 Q9H467 Q9H467 CUEDC2 CUE domain-containing protein 2 1 14386300.0 4419600.0 7060100.0 2906600.0 True False 3675093.2214774163 7022065.839979872 3514356.6214000313 1.0 1.9107177469519934 0.9562632590819649 21.8093494147718 -6.6568044105519135 1.9843373736788121 1.58775127477741 0.9602658636293632 0.22211129667158802 0.38806040319100993 0.4920338698563029 3.721006408429222 0.15818908299615794 0.43002025992013976 2.2039187994220238e-07 6.6568044105519135 -0.6274854111480469 DELLK(ub)DLQQSIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DELLKDLQQSIAR 13 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 13228200.0 1900600.0 6520800.0 4806800.0 True False 2491705.0054365797 5547922.057879326 4309438.446081436 1.0 2.226556532885905 1.729513901797683 21.248701846199125 -10.409972467246707 5.4481106557720125 0.9994032132424696 1.978035217341802 0.8377283133634832 0.20291680442945684 0.001471719956618977 0.00015938655737978937 0.1965820933240136 0.0654911170184052 3.8906980987948147e-11 10.409972467246707 0.9786320040993325 DELLK(ub)DLQQSIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DELLKDLQQSIAR 13 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 27925900.0 7005300.0 9211500.0 11709100.0 True False 6782920.586007353 12889699.987337906 8642135.444529528 1.0 1.9003171014457065 1.274102406912679 22.693475171254033 -10.22946555825329 5.7595115319565275 0.999978576469662 1.5872097541792025 0.5396812987204269 0.2556510785064933 7.033029255409259e-05 9.409157735356993e-06 0.247542105593565 0.08251103079129607 5.895687309907493e-11 10.22946555825329 0.5872311777095405 DELLK(ub)DLQQSIAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DELLKDLQQSIAR 13 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 69327100.0 14425400.0 26477000.0 28424700.0 True False 21884386.43800316 21751972.484254796 22806545.5860114 1.0 0.9939493869694047 1.042137765690651 24.383398600609848 -6.875422200758515 1.1050796814114134 0.9964359797935775 1.045265805392006 0.9697982797182706 0.0037247418590077084 0.13175895709984714 0.2974872367607637 0.0026063482710625904 0.0062353890793294614 1.3322256750113025e-07 6.875422200758515 0.04882982559842863 DELLK(ub)DLQQSIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DELLKDLQQSIAR 13 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 16116700.0 1900600.0 5627100.0 8589000.0 True False 2603303.181783754 5378476.1156687 6560455.0960076 1.0 2.066019875558032 2.520050350613581 21.311911907722017 -9.792928800659755 0.2217885070087283 1.6995726191145317e-18 2.8616294071402715 0.999285577495242 0.01702890700132432 1.23951259897253 0.09608950449323359 1.0273335061950504 0.23529757811233154 1.6109097101598719e-10 9.792928800659755 2.8616294071402715 DELLK(ub)DLQQSIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DELLKDLQQSIAR 13 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 27435400.0 7005300.0 13211300.0 7218800.0 True False 5825217.337409668 13140128.104662253 8728217.704039976 1.0 2.2557318196998546 1.4983505676238342 22.47388044668831 -10.08691707190586 4.869809425115529 0.9999722178297311 1.877041193657565 0.6413104643326539 0.30919960142095165 40630721.176154345 84159093.51027195 8740.730635640506 0.10584724264071008 8.186210880843656e-11 10.08691707190586 0.8770689758278339 DELLK(ub)DLQQSIAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DELLKDLQQSIAR 13 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 60348400.0 14425400.0 25756000.0 20167000.0 True False 18673964.667145137 24322655.958656374 16496812.930894315 1.0 1.3024901991728361 0.8834124528423635 24.154524922702297 -6.713037830292969 1.7843072200104573 1.1853825477138111 0.8843028017386542 0.47956250636963205 0.12740868733779565 0.36899527735514276 2.291858726685572 0.05678324718730106 0.14373095203120437 1.9362532944773719e-07 6.713037830292969 -0.30107974597515696 DELMAAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DELMAAVR 8 0 Q15008;Q15008-4;C9J7B7 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 0 5289600.0 792500.0 1480200.0 3016900.0 False True 1038975.174580918 1259359.9297744094 2704740.1281482666 1.0 1.212117440902653 2.6032769543692447 19.98672975201973 -6.933982643008663 0.7133495938151998 0.9816473866102976 2.920169812397313 0.9972646445678266 0.03719034799231227 0.09062200029261856 0.0679331329863068 0.03472398028472765 0.12323589423418496 1.1641725557423375e-07 6.933982643008663 1.9385224257870153 up DELTEIFK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 DELTEIFKK 9 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 9495200.0 2548600.0 2818500.0 4128100.0 True False 3341239.280677504 2397990.7864269493 3700963.8115313333 1.0 0.7176950182211159 1.107662008205796 21.671951873363582 -6.712531843466751 1.7862776161323097 0.8268922662092827 1.106811063346478 0.4770344367386442 0.1189162473560682 0.37002985891623197 2.3030958553611804 0.052947687594051676 0.13409572314231127 1.938510494708963e-07 6.712531843466751 0.27991879713719536 DELTEIFK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 DELTEIFKK 9 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 21719100.0 7375400.0 4667300.0 9676400.0 True False 7141271.96408985 6530977.229647967 7141860.554222409 1.0 0.9145397714145641 1.000082420909821 22.767749631372645 -9.949899822249204 4.394025863931725 1.0000009385095576 0.957311096249376 0.2492773635567287 0.03492264046536963 23947907.17938229 1.689291282127109 251.47248022476157 0.011954948712083911 1.1222772976777437e-10 9.949899822249204 -0.042689842260181576 DELTEIFK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 DELTEIFKK 9 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 52529200.0 7631200.0 24123000.0 20775000.0 True False 11577088.315449791 19818062.176140744 16668812.143994018 1.0 1.7118347581138562 1.439810398764018 23.464769119519683 -10.486994640216807 5.753750856217464 0.9993564479988807 1.5758225784389368 0.8566202514306505 0.11105347966910016 0.0009177450076279237 8.18258885057194e-05 0.10763936341554226 0.03584235644140054 3.258407222938352e-11 10.486994640216807 0.5764661304400561 DELTEIFK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DELTEIFKK 9 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 10886400.0 2548600.0 3212800.0 5125000.0 True False 3490886.2933253036 3070847.8726911545 3914580.5526882005 1.0 0.8796757083044277 1.1213715440038867 21.735161934886474 -6.771354939663626 1.5693895361418593 0.9311048266583148 1.122797336711087 0.7356822858170735 0.05072920243604764 0.26423922091740865 1.2846156912411422 0.025476507182661378 0.06056655970053925 1.6929536198273905e-07 6.771354939663626 0.1916925100527722 DELTEIFK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DELTEIFKK 9 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 18700700.0 7375400.0 6679900.0 4645400.0 True False 6132971.88561964 6643914.052843655 5616731.662097192 1.0 1.0833106977747693 0.915825437789319 22.54815490680692 -6.771500083917173 1.569139970273394 1.0476942083859935 0.9148392465626897 0.7361067798932205 0.0351250542860565 0.2640144939788821 1.283183884538259 0.017643673931465594 0.04193438172111265 1.692387917422307e-07 6.771500083917173 -0.1328549618233038 DELTEIFK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DELTEIFKK 9 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 44792200.0 7631200.0 18713000.0 18448000.0 True False 9878738.833440857 17671605.099950954 15090653.292464856 1.0 1.7888523421765337 1.5275890522969358 23.235895441612133 -10.222019965969936 4.715421537962844 0.9998587892611404 1.6582206972393423 0.8943254148670878 0.10666029146325653 0.00015837423053432172 2.6129851174549016e-05 0.10329528954542007 0.034424461043634405 5.997635024874211e-11 10.222019965969936 0.6583619079782019 DENK(ub)LSSANGHEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DENKLSSANGHEER 14 1 Q14498-3;Q14498-2;Q14498;G3XAC6;Q5QP23;Q5QP22;F8WF24;F2Z2Z5;H0Y6I9;A8MYG5 Q14498-3 RBM39 RNA-binding protein 39 1 2949290.0 702690.0 1057500.0 1189100.0 True False 909646.0570907025 998649.1953827894 972696.0011963323 1.0 1.0978437026119185 1.069312611882561 19.794945776879565 -10.03734338424928 4.2562431884974705 0.9999935038559469 1.083578157266581 0.9196246041475247 0.011647769088529054 8057555.750083111 0.15689616474525958 527.5195410400675 0.003987341160716083 9.176067840920497e-11 10.03734338424928 0.08358465341063415 DENSVELTMAEGPYK ddPTM_RPMI8226_Bortezomib_1h_R1 2 DENSVELTMAEGPYK 15 0 Q14697;F5H6X6;Q14697-2;E9PKU7;E9PNH1 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 36636900.0 6544700.0 13995200.0 16097000.0 False True 8580165.078964964 11907170.71286233 14431436.853327138 1.0 1.3877554339897045 1.6819532865057674 23.03257397419504 -6.974183420465242 0.12219778868618111 0.48801342953523014 2.589266254531001 0.9999994025808231 0.00021578500373342985 0.07496715354613266 0.0036452272234976622 0.020204803305224762 0.04188657077464009 1.0612472540673673e-07 6.974183420465242 2.101252824995771 DENSVELTMAEGPYK ddPTM_RPMI8226_Bortezomib_2h_R1 2 DENSVELTMAEGPYK 15 0 Q14697;F5H6X6;Q14697-2;E9PKU7;E9PNH1 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 32997190.0 10019300.0 3520490.0 19457400.0 False True 9701242.805787541 4926240.016112824 14360923.230512073 1.0 0.5077947346265719 1.4803178848327219 23.209738149087187 -6.769122351099301 1.5779314520839385 0.7173676560261556 1.4855929738792704 0.7271572028323876 0.20739170580163094 0.2678469949184063 1.3160445965977565 0.10360939350718024 0.24682059585184582 1.701679037344589e-07 6.769122351099301 0.7682253178531148 DENSVELTMAEGPYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DENSVELTMAEGPYK 15 0 Q14697;F5H6X6;Q14697-2;E9PKU7;E9PNH1 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 20108200.0 4518200.0 7208900.0 8381100.0 False True 6188700.639763956 6890386.961355589 6401656.794172689 1.0 1.1133818490238683 1.0344104791626916 22.56120510681773 -10.052245693840108 4.463828814710902 0.9999962450052703 1.0738961640945948 0.538631133929385 0.03223992676404565 3678951.654811396 8284754.346656962 85.76127336573845 0.011036585395328112 8.866542623445239e-11 10.052245693840108 0.07389991908932447 DENSVELTMAEGPYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DENSVELTMAEGPYK 15 0 Q14697;F5H6X6;Q14697-2;E9PKU7;E9PNH1 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 14691700.0 8487400.0 3338000.0 2866300.0 False True 7057649.155572327 3320017.531458876 3465630.077726185 1.0 0.47041407957174736 0.4910459561438976 22.750756283077873 -10.76082535685325 10.793339576838452 1.001361131472562 0.4807300178688519 0.9988173980449508 0.008422928339641773 0.0002762875644112623 6.1223730172670296e-06 0.008167495028046211 0.0027184884321442573 1.7345013537850813e-11 10.76082535685325 -0.5206311136037101 DENVLK(ub)SEPMGNAEEPEIPYSYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DENVLKSEPMGNAEEPEIPYSYSR 24 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-14;A0A0C4DGN9 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 40685600.0 1526300.0 5332300.0 33827000.0 True False 2000994.0807102246 4536741.625142602 30326906.531496428 1.0 2.2672439008576926 15.155920161808934 20.93228546883038 -6.925921061314389 0.779544722039621 0.7715617972812554 17.54654374450387 0.995674089789172 0.4206381305016685 0.0948116906176273 0.08846592072912499 0.37430051334059766 1.1934240065076243 1.1859842966892357e-07 6.925921061314389 16.774981947222617 DENVLK(ub)SEPMGNAEEPEIPYSYSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DENVLKSEPMGNAEEPEIPYSYSR 24 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-14;A0A0C4DGN9 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 97162500.0 1652100.0 8828400.0 86682000.0 True False 1599654.9898138181 12353626.159497809 63977383.795740865 1.0 7.722681602071977 39.994488938634895 20.609329350588663 -6.940718623142569 0.6528513510845395 0.6417614650100782 48.884058799598215 0.9982564218044927 0.7107051771237615 0.08744051799076304 0.05312971222055149 0.6956401756744527 2.7688968827185643 1.1462553530636682e-07 6.940718623142569 48.24229733458814 DENVLK(ub)SEPMGNAEEPEIPYSYSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DENVLKSEPMGNAEEPEIPYSYSR 24 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-14;A0A0C4DGN9 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 45886300.0 1526300.0 5612000.0 38748000.0 True False 2090614.3567065902 5364043.283597718 29596520.44010972 1.0 2.565773676235469 14.15685314948953 20.99549553035327 -6.931569551595996 0.7337958718767164 0.8335970611741147 16.634418795253733 0.9968378011855868 0.3299813637550499 0.09183102885556008 0.07374783074180885 0.30348548516320734 1.0398888536550648 1.1706591080443206e-07 6.931569551595996 15.80082173407962 DENVLK(ub)SEPMGNAEEPEIPYSYSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DENVLKSEPMGNAEEPEIPYSYSR 24 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-14;A0A0C4DGN9 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 65401900.0 1652100.0 7401800.0 56348000.0 True False 1373794.3504395965 7361925.034257727 68130106.27628472 1.0 5.3588261095279695 49.592652826446674 20.38973462602294 -6.925956882685303 0.7792618107815069 0.21703612666465188 57.80443672938382 0.9956822012562323 1.4424424026982556 0.09479238582237624 0.0883674581744603 1.2837955885036834 4.094980445646528 1.1858864786575822e-07 6.925956882685303 57.58740060271917 DEPNSTPEK(ub)TEQFYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DEPNSTPEKTEQFYR 15 1 O76021;J3QSV6;I3L3U9;I3L3C4;I3L234 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 7955800.0 3021200.0 3289500.0 1645100.0 True False 3960822.457342422 2798719.4223705702 1474880.8329134923 1.0 0.7066005741263183 0.37236731734324885 21.91736860365122 -7.0004420418475695 0.27551784919408123 1.0791113428716161 3.6102639414698334e-10 0.9999775782943409 0.0012141308773791157 0.0734405388181627 0.0097498279523388 0.006348457174081404 0.029836217234788825 9.989826788536887e-08 7.0004420418475695 -1.0791113425105898 down DEPNSTPEK(ub)TEQFYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DEPNSTPEKTEQFYR 15 1 O76021;J3QSV6;I3L3U9;I3L3C4;I3L234 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 9160400.0 3822600.0 4022600.0 1315200.0 True False 3178661.269893109 4000929.455376416 1590202.2392022714 1.0 1.2586838029177478 0.5002742048245192 21.599987854978263 -6.814634978147215 1.3947726948524313 1.1402298356468934 0.4855262773138122 0.8716370415507236 0.11278185363937802 0.20054071463311435 0.7679522244191024 0.06356237071154576 0.14676206301408257 1.5323748722730519e-07 6.814634978147215 -0.6547035583330811 DEQEHEFYK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 DEQEHEFYK 9 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 3255650.0 1008700.0 977350.0 1269600.0 True False 1322415.4682646946 831533.1896804612 1138233.9708631507 1.0 0.6287987471680281 0.8607234248074613 20.334744074337948 -10.450183065969501 5.828024338841539 1.0001594411487333 0.7447610859877446 0.6175723659145502 0.09468285316268168 0.00019627453819104276 1.8516637995941037e-05 0.09173312353123071 0.03055875945587228 3.546638580472477e-11 10.450183065969501 -0.25539835516098874 DEQEHEFYK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 DEQEHEFYK 9 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 5316100.0 1078100.0 1883500.0 2354500.0 True False 1043876.3056221029 2635591.372322742 1737785.816514059 1.0 2.5248119515003733 1.664743042020115 19.99351933885832 -10.267646238037077 7.014068256787655 0.9999920100042099 2.094777496760244 0.6835792734918158 0.3511216619764344 4.387161304442275e-05 4.580637738373953e-06 0.3399745588914999 0.11332402911061674 5.399502691129064e-11 10.267646238037077 1.0947854867560343 DEQEHEFYK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 DEQEHEFYK 9 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 13452400.0 3113300.0 6728800.0 3610300.0 True False 4723103.712717514 5527993.067645639 2896722.6225492973 1.0 1.1704153463242541 0.6133091286455409 22.17130378471535 -6.824618463700109 1.3519014238713185 1.0914471012668154 0.5999116615667791 0.8946543190731697 0.07565092718712305 0.1875460732063152 0.672237585284178 0.04396049228062676 0.10121246480754462 1.4975507063028817e-07 6.824618463700109 -0.4915354397000363 DEQEHEFYK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DEQEHEFYK 9 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 3516400.0 1008700.0 1130300.0 1377400.0 True False 1381643.6490925355 1080359.6085977368 1052086.4884434582 1.0 0.7819379543396141 0.7614745590402195 20.39795413586084 -13.999999999992596 0.334716318814697 3.442375240210539 0.758047588997852 0.9997245433666561 0.001791499603036541 19.22948943041618 0.18526740303407316 33.14266532756223 0.00644426983656252 1.000000000017048e-14 13.999999999992596 -2.684327651212687 DEQEHEFYK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DEQEHEFYK 9 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 6010200.0 1078100.0 3268300.0 1663800.0 True False 896487.917928048 3250693.0191932465 2011692.8874579843 1.0 3.6260310420091426 2.2439709975203956 19.773924614292596 -10.148896616602356 7.466825759200893 0.9999991457580055 2.935001019764769 0.7232714291969881 0.5642236504809414 8.024394451802552e-06 9.125293720129007e-07 0.5463074364207164 0.18210240015408677 7.09746702397888e-11 10.148896616602356 1.9350018740067636 DEQEHEFYK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DEQEHEFYK 9 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 15414400.0 3113300.0 9148100.0 3153000.0 True False 4030228.2223177827 8639000.193173815 2579186.352512013 1.0 2.1435511133921663 0.6399603720279454 21.942430106807798 -6.703358269224057 1.81875129019309 1.7077352026198451 0.6441157154081655 0.43362683755142406 0.4824149326650056 0.38856024079460444 2.5010364372414515 0.2114167268234964 0.541494103843857 1.9798930483142825e-07 6.703358269224057 -1.0636194872116795 DEQINK(ub)GHCDSSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DEQINKGHCDSSTR 14 1 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 11917100.0 3265600.0 4046800.0 4604700.0 True False 4281233.22411538 3443033.2143028546 4128249.815401353 1.0 0.8042152889286426 0.9642665090394281 22.029594999138315 -10.015175821710542 5.553608313821513 1.0000003928506027 0.8842408990173554 0.410891041488332 0.06534063699718773 3.177868433765786e-07 5.652766434586394e-08 0.06326601372966616 0.02108859991001355 9.656598578100253e-11 10.015175821710542 -0.11575949383324735 DEQINK(ub)GHCDSSTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DEQINKGHCDSSTR 14 1 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 5203800.0 1978500.0 1315500.0 1909800.0 True False 1915693.6004761446 1840786.0102418722 1409566.0872280959 1.0 0.9608979274056905 0.7357993401855856 20.86943540157669 -6.936717165513338 0.6894259060261331 1.002726674831852 0.6805429548610838 0.9977015405065811 0.005581840876866353 0.08929672343687663 0.06167173610775452 0.005306796892442881 0.019670284141115324 1.1568654060589472e-07 6.936717165513338 -0.3221837199707681 DEQINK(ub)GHCDSSTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DEQINKGHCDSSTR 14 1 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 22132400.0 5695000.0 3171400.0 13266000.0 True False 8639731.36026923 2605438.891738704 10643969.285305634 1.0 0.3015648037067571 1.2319791948917667 23.042555023931357 -6.70580479471974 1.8099505177617623 0.5687988919807467 1.2295554599795702 0.4452781911032945 0.294516240391875 0.3835585804620098 2.446586046704333 0.12961652371527121 0.33099871577429396 1.9687710076921157e-07 6.70580479471974 0.6607565679988234 DEQINK(ub)GHCDSSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DEQINKGHCDSSTR 14 1 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 14119300.0 3265600.0 4080600.0 6773100.0 True False 4472980.569521743 3900305.5992603106 5173433.276373156 1.0 0.871970163661439 1.1565964117135226 22.092805060661206 -6.784457657464553 1.5188171646405297 0.9279245154199 1.1591612250807986 0.7827325460802952 0.05425309990308266 0.24371724798292646 1.1107303612066641 0.028128512557218266 0.06611976449299362 1.642639804798581e-07 6.784457657464553 0.2312367096608986 DEQINK(ub)GHCDSSTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DEQINKGHCDSSTR 14 1 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 8142170.0 1978500.0 811470.0 5352200.0 True False 1645210.4124113196 807098.450045817 6471320.274223233 1.0 0.49057460611550885 3.9334301712438564 20.649840677010967 -6.869273790306027 1.1379991167784849 0.7131428910114668 4.132238238862039 0.9639494606329734 0.28807545077231944 0.13754944336797828 0.33339197647157404 0.1965514188516977 0.4647428067171477 1.3512204508282253e-07 6.869273790306027 3.419095347850572 up DEQINK(ub)GHCDSSTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DEQINKGHCDSSTR 14 1 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 18280800.0 5695000.0 3753300.0 8832500.0 True False 7372289.765232948 3544425.5555841406 7225075.6291032 1.0 0.48077675572375506 0.9800314229611543 22.813681346023806 -10.77672960198264 10.222055722346807 1.0014074431143105 0.7304040893424547 0.2799515097967352 0.20381986440577304 0.006564523545060582 0.00014338219199907208 0.19816073291811198 0.0657825783724844 1.6721313834296486e-11 10.77672960198264 -0.2710033537718558 DESSPYAAMLAAQDVAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DESSPYAAMLAAQDVAQR 18 0 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 6959000.0 0.0 3441700.0 3517300.0 False True 0.0 2928211.775641527 3153363.5363240126 0.0 DESSPYAAMLAAQDVAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DESSPYAAMLAAQDVAQR 18 0 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 7096500.0 0.0 3577200.0 3519300.0 False True 0.0 3419147.4757814985 2688113.822258646 0.0 DESTNVDMSLAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DESTNVDMSLAQR 13 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 14215800.0 2111300.0 5468400.0 6636100.0 False True 2767934.745858287 4652536.035656247 5949460.029966096 1.0 1.6808691182542959 2.149422069602033 21.40037850112239 -7.946398564510522 0.1233338975666513 3.1264382095874485e-17 3.3820913909649257 0.9999788630309385 0.002169598954189655 0.1167363827191151 0.019776063981896932 0.22858788468211472 0.2763849737713298 1.1313616036443817e-08 7.946398564510522 3.3820913909649257 DESTNVDMSLAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DESTNVDMSLAQR 13 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 8215860.0 2624700.0 938360.0 4652800.0 False True 2541380.3351881434 1313052.041482754 3434092.098991983 1.0 0.5166688446046964 1.3512704302631469 21.277180870189195 -6.749645312573508 1.6508372249283754 0.7156902465655807 1.3529223287257173 0.647641698015004 0.20309563059766148 0.30062902003496095 1.611795766337732 0.09718406433985645 0.23605418370455922 1.7797323204563472e-07 6.749645312573508 0.6372320821601366 DESTNVDMSLAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DESTNVDMSLAQR 13 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 9466200.0 2111300.0 3822500.0 3532400.0 False True 2891904.665737162 3653609.3106828765 2698119.8720616144 1.0 1.2633920315459473 0.9329906009795276 21.46358856264528 -6.694421424991391 1.851491852716582 1.1644479543381485 0.9340923640563086 0.3908817028697599 0.11129907892827016 0.40720957709718314 2.7099483381509253 0.048038104540093725 0.12436571100492061 2.021057059964658e-07 6.694421424991391 -0.23035559028183994 DETEFYLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DETEFYLGK 9 0 P18077;C9K025;F8WBS5;F8WB72 P18077 RPL35A 60S ribosomal protein L35a 0 20874200.0 3041200.0 6609000.0 11224000.0 False True 3987042.651022695 5622962.961680232 10062648.148210468 1.0 1.4103092075621302 2.523837598183042 21.926887607839706 -6.953679715260975 0.5168708555674538 0.9806102299743402 3.002964690641489 0.9994593103932662 0.014970257458786884 0.08204095170476024 0.030101266913892914 0.017045128786704934 0.09195114388023387 1.1125519127807993e-07 6.953679715260975 2.022354460667149 up DETEFYLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DETEFYLGK 9 0 P18077;C9K025;F8WBS5;F8WB72 P18077 RPL35A 60S ribosomal protein L35a 0 12552300.0 3413800.0 1068800.0 8069700.0 False True 3305430.7876196457 1495577.413718369 5956003.484189225 1.0 0.4524606654358011 1.8018841920687585 21.65640687575061 -6.796546455573875 1.4699844831103868 0.696571077223592 1.8189623282166647 0.8218923921423318 0.23386770656411723 0.2257105476086939 0.963214986655889 0.12518293288282464 0.2917614843033983 1.597546633691089e-07 6.796546455573875 1.1223912509930727 DETEFYLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DETEFYLGK 9 0 P18077;C9K025;F8WBS5;F8WB72 P18077 RPL35A 60S ribosomal protein L35a 0 21355500.0 3041200.0 9246800.0 9067500.0 False True 4165613.8253397667 8838245.8009215 6925943.251024437 1.0 2.1217151112658916 1.66264650095344 21.990097669362598 -10.215648944975 4.997226293939204 0.9998926324212337 1.8921808061105556 0.8343285054422449 0.18741397536876525 0.00022421116802146391 3.519164323205276e-05 0.18148435787036113 0.06048760045370484 6.086267762502761e-11 10.215648944975 0.8922881736893219 DETEFYLGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DETEFYLGKR 10 1 P18077;C9K025;F8WBS5;F8WB72 P18077 RPL35A 60S ribosomal protein L35a 1 20175690.0 4193700.0 5438390.0 10543600.0 True False 4060573.289015319 7609967.487829199 7781914.858780053 1.0 1.8741115961176509 1.9164571859426165 21.95325199693936 -11.07499034104896 0.5237548065756272 5.650517205114822e-13 1.9137005361876396 0.9998377181188741 0.00538088313436232 3.0110060256372004 0.2556359009181498 3.595802417832144 0.008252560801013786 8.414138549496295e-12 11.07499034104896 1.9137005361870745 DETEFYLGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DETEFYLGKR 10 1 P18077;C9K025;F8WBS5;F8WB72 P18077 RPL35A 60S ribosomal protein L35a 1 60645000.0 11312900.0 15734800.0 33597300.0 True False 17162496.383773465 12926802.003446488 26956778.928780273 1.0 0.7532005667700139 1.5706793654020494 24.032756080600656 -6.825732254719653 1.3468005464196402 0.8676877714477874 1.5908307512655864 0.8970784994296832 0.1098318978192561 0.18613823359623205 0.6617873567462073 0.06405517896551546 0.14746747442544195 1.4937150104730026e-07 6.825732254719653 0.723142979817799 DETEFYLGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DETEFYLGKR 10 1 P18077;C9K025;F8WBS5;F8WB72 P18077 RPL35A 60S ribosomal protein L35a 1 36134630.0 4193700.0 6241630.0 25699300.0 True False 3487247.36241059 6208005.1003234405 31072904.809862345 1.0 1.7802021064637361 8.910438973959947 21.733657272373637 -6.927707838587229 0.7653757974897775 0.8818537962240046 10.292296630521854 0.9960682260448256 0.22318819713891896 0.09384554328008383 0.0836405788206862 0.2006288759995436 0.6534833991526987 1.1811149357815347e-07 6.927707838587229 9.410442834297848 up DETEFYLGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DETEFYLGKR 10 1 P18077;C9K025;F8WBS5;F8WB72 P18077 RPL35A 60S ribosomal protein L35a 1 168870400.0 11312900.0 18886500.0 138671000.0 True False 14644772.060597701 17835449.672432188 113434300.88461585 1.0 1.2178714423571755 7.745719797839327 23.803882402693105 -6.913995417024749 0.8680898078540712 0.8225202864442548 8.66559149006832 0.9923438960422531 0.27386137291101065 0.10183468942886321 0.12487651170400477 0.2287412650840814 0.6503509537216449 1.2190024626126937e-07 6.913995417024749 7.843071203624064 up DETGELSSADEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DETGELSSADEKR 13 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 1 7499200.0 3274000.0 2394900.0 1830300.0 True False 4292245.7054611035 2037590.2552470835 1640918.1134773344 1.0 0.47471426266548994 0.3822982713663302 22.033301233467114 -13.999999999999998 0.2444280570952742 4.55299707315531 0.3431187548182558 0.9995325350844425 0.005881621715700283 13.783941868758639 0.15645851604098046 23.96679446934158 0.04401231348959681 1.0000000000000041e-14 13.999999999999998 -4.209878318337054 DETGELSSADEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DETGELSSADEKR 13 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 1 12151600.0 5021800.0 4585500.0 2544300.0 True False 4862385.707794345 6416514.063066606 1877871.5026361097 1.0 1.3196225985900323 0.3862037311490745 22.213232908731758 -6.814241057990252 1.396374471952551 1.173333371387224 0.3681919226042991 0.8707098457108228 0.13926966877926855 0.20104508374363633 0.7717305425959541 0.07840223567001958 0.181059708441077 1.533765419969042e-07 6.814241057990252 -0.8051414487829249 down DETGELSSADEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DETGELSSADEKR 13 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 1 11993020.0 6163000.0 4837500.0 992520.0 True False 9349721.575652208 3974210.3294399832 796347.9869630301 1.0 0.42506189059033606 0.0851734439918313 23.156491973104494 -8.458021257452081 0.38209013547893395 1.1054667138767387 2.658512299173545e-26 0.9973074911552321 0.01959152257848843 0.16927306624817356 0.11228729383920696 0.09514522965328523 0.08234437081891469 3.483202653545785e-09 8.458021257452081 -1.1054667138767387 DETGELSSADEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DETGELSSADEKR 13 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 1 7331100.0 3274000.0 2438000.0 1619100.0 True False 4484486.276523215 2330281.0986121222 1236701.926411212 1.0 0.519631671259962 0.27577337740679114 22.096511294990005 -9.660452446820747 0.17979231866728987 1.5736735431550477 1.113719130235133e-12 0.9996031919488524 0.00599341360786109 1.1085683978122052 0.0747476867725039 0.4864864616772158 0.16088373683278342 2.1854836066083226e-10 9.660452446820747 -1.573673543153934 DETGELSSADEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DETGELSSADEKR 13 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 1 11744500.0 5021800.0 5360600.0 1362100.0 True False 4175849.2034607898 5331721.383804206 1646908.8123611743 1.0 1.2767993105176 0.3943889571003371 21.993638184166034 -6.822389236997802 1.3613957456255938 1.14884835535886 0.3741036176213128 0.8898033704155028 0.12232182321033606 0.19040205437926772 0.6927328606919314 0.07059230843496524 0.16261834568468622 1.5052573725545426e-07 6.822389236997802 -0.7747447377375472 down DETNYGIPQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DETNYGIPQR 10 0 P63244;D6RAC2;D6REE5;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RBD0;D6RFZ9;E9PD14;D6RAU2;D6RGK8;D6R909 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 29646900.0 7866500.0 3024400.0 18756000.0 False True 7616782.263404393 4232058.692037647 13843240.93206105 1.0 0.5556229055372902 1.8174657556606697 22.860750224122707 -6.811529676358706 1.4080533253283372 0.7582536935660457 1.8403312078138603 0.8637965913799167 0.19286832211683996 0.20471983832920151 0.7996549349406165 0.10769453349163574 0.24895610212476765 1.543370957570386e-07 6.811529676358706 1.0820775142478145 DEVDGGPPCAPGGTAK(ub)TR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DEVDGGPPCAPGGTAKTR 18 1 Q9NV96-2;Q9NV96;A0A669KBF5;A0A669KBE6;A0A669KB92;A0A669KBA0 Q9NV96-2 TMEM30A Cell cycle control protein 50A 1 14360200.0 4919200.0 4040800.0 5400200.0 True False 6449118.837600557 3437928.39091503 4841439.106376176 1.0 0.5330849806753037 0.7507132723541918 22.620670623586083 -10.096624615501595 5.172743466862406 1.0000076045980102 0.6418991265141492 0.7830847925199371 0.08884637803656457 7.791971891767673e-06 1.3606764950246223e-06 0.08602696223748867 0.02867504520857168 8.005258944125333e-11 10.096624615501595 -0.35810847808386104 DEVDGGPPCAPGGTAK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DEVDGGPPCAPGGTAKTR 18 1 Q9NV96-2;Q9NV96;A0A669KBF5;A0A669KBE6;A0A669KB92;A0A669KBA0 Q9NV96-2 TMEM30A Cell cycle control protein 50A 1 9200200.0 2940900.0 3085500.0 3173800.0 True False 2847542.739267273 4317556.24066994 2342486.5680409097 1.0 1.5162393108736725 0.8226343842844923 21.441286065082394 -6.707412762306108 1.8043828233424313 1.3182055952910852 0.8243812995828407 0.45283806990816844 0.21763020708210143 0.38029383028991626 2.4119259849968215 0.09604025986398007 0.2447600369348723 1.9614951457775885e-07 6.707412762306108 -0.4938242957082445 DEVDGGPPCAPGGTAK(ub)TR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DEVDGGPPCAPGGTAKTR 18 1 Q9NV96-2;Q9NV96;A0A669KBF5;A0A669KBE6;A0A669KB92;A0A669KBA0 Q9NV96-2 TMEM30A Cell cycle control protein 50A 1 19170600.0 7466400.0 6937600.0 4766600.0 True False 11327074.666955972 5699531.076283794 3824479.4207250057 1.0 0.503177673306137 0.3376405235397634 23.43327198270406 -13.999999999999998 0.15355655793012749 3.4164545185429778 0.16275896271157375 0.9995548057126122 0.0059386045387211815 11.97288162235059 0.12358470727342989 8.62492764659383 0.1581997183736889 1.0000000000000041e-14 13.999999999999998 -3.253695555831404 DEVDGGPPCAPGGTAK(ub)TR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DEVDGGPPCAPGGTAKTR 18 1 Q9NV96-2;Q9NV96;A0A669KBF5;A0A669KBE6;A0A669KB92;A0A669KBA0 Q9NV96-2 TMEM30A Cell cycle control protein 50A 1 13963800.0 4919200.0 5562500.0 3482100.0 True False 6737961.176381478 5316730.357272326 2659699.6961005954 1.0 0.7890710881370196 0.3947336036045473 22.683880685108974 -6.961342436467259 0.4160817808166934 1.0181833815576125 0.15084105238229426 0.999816792962902 0.003395376909490823 0.07922501371991775 0.019384826810770105 0.005089766615332417 0.03286236887533149 1.0930941335713701e-07 6.961342436467259 -0.8673423291753182 down DEVDGGPPCAPGGTAK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DEVDGGPPCAPGGTAKTR 18 1 Q9NV96-2;Q9NV96;A0A669KBF5;A0A669KBE6;A0A669KB92;A0A669KBA0 Q9NV96-2 TMEM30A Cell cycle control protein 50A 1 8901900.0 2940900.0 2535800.0 3425200.0 True False 2445488.6539603006 2522139.1420831103 4141393.483664551 1.0 1.031343628603093 1.6934830087875685 21.22169134051667 -6.916771893646553 0.8483142214526351 0.9836228517088953 1.7927176375614322 0.99323650635752 0.026298803399946093 0.10010846098296466 0.11572795835455645 0.02228004637716127 0.06481273335062901 1.2112341482142337e-07 6.916771893646553 0.8090947858525369 DEVDGGPPCAPGGTAK(ub)TR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DEVDGGPPCAPGGTAKTR 18 1 Q9NV96-2;Q9NV96;A0A669KBF5;A0A669KBE6;A0A669KB92;A0A669KBA0 Q9NV96-2 TMEM30A Cell cycle control protein 50A 1 14891200.0 7466400.0 3566100.0 3858700.0 True False 9665401.984747207 3367643.400146165 3156456.1936054933 1.0 0.34842248728615544 0.32657267629288866 23.20439830479651 DEVESLMCEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DEVESLMCEKR 11 1 K7EL10;Q16512;Q16512-2 K7EL10 PKN1 Serine/threonine-protein kinase N1 1 4640700.0 1033900.0 1976700.0 1630100.0 True False 1355452.912301841 1681784.0651162507 1461432.8890233315 1.0 1.240754326360354 1.0781878704598558 20.37034356492799 -10.417221523996798 4.920834122932413 0.9997837651098395 1.1594710984101286 0.5619878840368033 0.06636747770823041 0.00015765486201100955 1.8671204470190672e-05 0.06434678219338341 0.021420011324468847 3.826295226868583e-11 10.417221523996798 0.15968733330028917 DEVESLMCEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DEVESLMCEKR 11 1 K7EL10;Q16512;Q16512-2 K7EL10 PKN1 Serine/threonine-protein kinase N1 1 20337600.0 2634100.0 11130000.0 6573500.0 True False 3996122.278504866 9143764.540913077 5274244.843732599 1.0 2.2881593463987246 1.3198407046007454 21.930169298574008 -10.185159833543757 4.6455773949331185 0.999869521485942 1.8040000255053386 0.47895201026676737 0.39531443016219964 277493172.2411964 97.04229780048539 391165.6555603387 0.13532664418837856 6.528902250178835e-11 10.185159833543757 0.8041305040193966 DEVESLMCEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DEVESLMCEKR 11 1 K7EL10;Q16512;Q16512-2 K7EL10 PKN1 Serine/threonine-protein kinase N1 1 15294300.0 2634100.0 6333900.0 6326300.0 True False 3409894.375873597 5981412.897054422 5174978.31331962 1.0 1.7541343624528005 1.5176359566837954 21.701295620666457 -10.120528630832313 4.771152199200537 0.9999595164209587 1.6358851595740587 0.9060077131339067 0.09655006987243903 4.1580589676982954e-05 7.664839300315999e-06 0.09349013683071185 0.03116140105478031 7.576547828826351e-11 10.120528630832313 0.6359256431531 DFCVK(ub)FPEEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFCVKFPEEIR 11 1 D6RID3;Q9HCC9-8;Q9HCC9-7;Q9HCC9-6;Q9HCC9-4;Q9HCC9-3;Q9HCC9-2;Q9HCC9 D6RID3 ZFYVE28 Lateral signaling target protein 2 homolog 1 441000000.0 83569000.0 183769000.0 173662000.0 True False 109559768.28334711 156351381.52595168 155693122.12353218 1.0 1.4270875520801627 1.4210793301504019 26.707142878987764 -10.111674008324364 4.857900791825377 0.9999794862116785 1.4240834411180496 0.9998494822905027 0.0024528463411043378 5.44994357796674e-07 9.966066730103009e-08 0.0023750730047793923 0.000791652751131625 7.732607950894952e-11 10.111674008324364 0.4241039549063711 DFCVK(ub)FPEEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFCVKFPEEIR 11 1 D6RID3;Q9HCC9-8;Q9HCC9-7;Q9HCC9-6;Q9HCC9-4;Q9HCC9-3;Q9HCC9-2;Q9HCC9 D6RID3 ZFYVE28 Lateral signaling target protein 2 homolog 1 174941000.0 91606000.0 51850000.0 31485000.0 True False 88698017.67258914 72553975.39417793 23238133.970246416 1.0 0.8179886912692492 0.2619915819993329 26.402398526055993 -6.9510434160083125 0.5472686698844318 1.0078167208466053 0.04616568203824514 0.9992806433359425 0.008419617237975251 0.083069443387442 0.03424915850757989 0.009170862709684528 0.04610139680866952 1.1193259799149863e-07 6.9510434160083125 -0.9616510388083602 down DFCVK(ub)FPEEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFCVKFPEEIR 11 1 D6RID3;Q9HCC9-8;Q9HCC9-7;Q9HCC9-6;Q9HCC9-4;Q9HCC9-3;Q9HCC9-2;Q9HCC9 D6RID3 ZFYVE28 Lateral signaling target protein 2 homolog 1 974580000.0 373250000.0 303520000.0 297810000.0 True False 566247538.2301129 249354484.58741602 238947722.96523982 1.0 0.4403630351609278 0.421984568289877 29.076857632132512 DFCVK(ub)FPEEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFCVKFPEEIR 11 1 D6RID3;Q9HCC9-8;Q9HCC9-7;Q9HCC9-6;Q9HCC9-4;Q9HCC9-3;Q9HCC9-2;Q9HCC9 D6RID3 ZFYVE28 Lateral signaling target protein 2 homolog 1 383732000.0 83569000.0 141541000.0 158622000.0 True False 114466717.6673085 135287250.60650474 121158750.52263544 1.0 1.1818915870350195 1.0584626954603258 26.770352940510655 -10.272119571674386 3.7526195998678182 0.9997797359480941 1.1201771411716785 0.5583048701471095 0.05038963415069625 47564374.72421505 27864002.623613577 101470.7118059893 0.018440715930879578 5.3441720128235474e-11 10.272119571674386 0.12039740522358444 DFCVK(ub)FPEEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFCVKFPEEIR 11 1 D6RID3;Q9HCC9-8;Q9HCC9-7;Q9HCC9-6;Q9HCC9-4;Q9HCC9-3;Q9HCC9-2;Q9HCC9 D6RID3 ZFYVE28 Lateral signaling target protein 2 homolog 1 309268000.0 91606000.0 34390000.0 183272000.0 True False 76174447.83388995 34204734.24411944 221593327.84601513 1.0 0.44903160071088544 2.9090244057854324 26.18280380149027 -6.847895517319719 1.2450757412898021 0.7064043315398658 3.003508533604478 0.93719669656194 0.2641552455884327 0.15979490493227627 0.47773038987920063 0.16609258030274826 0.38389631136417374 1.4193989599895937e-07 6.847895517319719 2.297104202064612 up DFCVK(ub)FPEEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFCVKFPEEIR 11 1 D6RID3;Q9HCC9-8;Q9HCC9-7;Q9HCC9-6;Q9HCC9-4;Q9HCC9-3;Q9HCC9-2;Q9HCC9 D6RID3 ZFYVE28 Lateral signaling target protein 2 homolog 1 855612000.0 373250000.0 241998000.0 240364000.0 True False 483179482.85745394 228530598.56666127 196620218.34291068 1.0 0.4729724805680162 0.4069299821675519 28.84798395422496 -13.999999999999998 0.2928838194407425 5.616004191562257 0.3894504277444995 0.9996339180961841 0.005077634225611424 16.139455552291142 0.17168615281131644 44.96304826913594 0.02462210373931389 1.0000000000000041e-14 13.999999999999998 -5.2265537638177575 DFDDEK(ub)ILIQHQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFDDEKILIQHQK 13 1 J3QRS9;O43670-2;O43670;O43670-4;X6R4W8;O43670-3 J3QRS9 ZNF207 BUB3-interacting and GLEBS motif-containing protein ZNF207 1 92818500.0 48389000.0 41035000.0 3394500.0 True False 46852917.681799494 57420489.49469804 2505378.6171828327 1.0 1.225547785191692 0.05347326785917696 25.481635556151414 -6.856827376244217 1.2015906700164076 1.121488713120183 3.972726771555294e-05 0.9496771461104295 0.11390852215115604 0.15010270963216685 0.41361980664535725 0.07402569182054644 0.17223493043033336 1.3905052206323562e-07 6.856827376244217 -1.1214489858524674 down DFFQSYGNVVELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFFQSYGNVVELR 13 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 11339700.0 3092200.0 3869300.0 4378200.0 False True 4053904.144907395 3292015.522413267 3925185.8626599344 1.0 0.812060523569303 0.9682483162782328 21.950880545819743 -10.06359273170769 5.6746498471931455 1.0000005333339548 0.8901544199473669 0.39740606336368367 0.06376339936483218 4.302555145154589e-07 7.10095033850628e-08 0.06173894587032066 0.020579548653117934 8.637882026479622e-11 10.06359273170769 -0.1098461133865879 DFFQSYGNVVELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFFQSYGNVVELR 13 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 18791600.0 3092200.0 5410400.0 10289000.0 False True 4235469.903562942 5171350.638199766 7858950.1086066095 1.0 1.2209626690652546 1.8555084294178412 22.014090607342634 -6.952428921723461 0.5315121542692061 0.990099645072524 2.115251841860936 0.9993783552048464 0.00904085753535278 0.08252487163461546 0.03203780997736549 0.010064075265733413 0.05248396376015961 1.1157607460296407e-07 6.952428921723461 1.1251521967884117 DFFTNHTLVLHVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFFTNHTLVLHVAR 14 0 Q9UM07 Q9UM07 PADI4 Protein-arginine deiminase type-4 0 17527100.0 3495200.0 8128300.0 5903600.0 False True 4582241.047564945 6915589.323865246 5292752.103329943 1.0 1.5092155240371452 1.155057546818182 22.127621922549814 -9.91746976406412 7.771914581215762 0.9999999997891895 1.3321365354276637 0.5397380606831901 0.1445843887537816 3.3654741015388984e-09 2.6841028145381063e-10 0.13999323244124368 0.046664410813747885 1.2092893717244394e-10 9.91746976406412 0.33213653563847423 DFFTNHTLVLHVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFFTNHTLVLHVAR 14 0 Q9UM07 Q9UM07 PADI4 Protein-arginine deiminase type-4 0 32999300.0 11383300.0 6947000.0 14669000.0 False True 11021943.372403389 9720973.3281264 10826748.839432897 1.0 0.8819654574224777 0.9822903705476098 23.39387528435862 -10.076581913064732 4.794638272170721 1.000002536503678 0.9321279139841537 0.3789761160588423 0.04095747427733395 1.1105711383211594e-06 2.1385283420687002e-07 0.03965838602812861 0.013218967981134172 8.383359436563908e-11 10.076581913064732 -0.06787462251952425 DFFTNHTLVLHVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFFTNHTLVLHVAR 14 0 Q9UM07 Q9UM07 PADI4 Protein-arginine deiminase type-4 0 127380000.0 33716000.0 38476000.0 55188000.0 False True 51149636.96976962 31609657.185639877 44280067.610240296 1.0 0.6179839986806117 0.8656966155284862 25.608220664812215 -10.266462416519996 5.035491754613775 1.0000522595124435 0.7418403071044333 0.5915315257541267 0.10112825235488218 5.93430575415044e-05 8.644677183782439e-06 0.09793679442303345 0.03263900310006826 5.4142410024264744e-11 10.266462416519996 -0.2582119524080102 DFFTNHTLVLHVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFFTNHTLVLHVAR 14 0 Q9UM07 Q9UM07 PADI4 Protein-arginine deiminase type-4 0 34728200.0 3495200.0 10626700.0 20606300.0 False True 4787469.894228443 10157177.256202415 15739516.340069994 1.0 2.12161694602977 3.2876481080423803 22.190831984072705 -6.97063707611309 0.24249104170613292 0.5940344736227602 4.849060582072248 0.9999869330980121 0.003376187512671271 0.07609655304711552 0.008287178974278383 0.02738791600443391 0.11317830337329633 1.0699486223532727e-07 6.97063707611309 4.255026108449488 DFFTNHTLVLHVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFFTNHTLVLHVAR 14 0 Q9UM07 Q9UM07 PADI4 Protein-arginine deiminase type-4 0 27526000.0 11383300.0 5263500.0 10879200.0 False True 9465718.315694608 5235144.480777047 13153990.420262603 1.0 0.5530636245636985 1.3896452420787406 23.174280559792898 -6.7616181244102895 1.6067840601330299 0.7409121164290172 1.3929048866105898 0.6973842210342089 0.18802589896077004 0.28020798156570953 1.4262282267521955 0.09232153186785602 0.22147425441997776 1.7313380574565724e-07 6.7616181244102895 0.6519927701815725 DFFTNHTLVLHVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFFTNHTLVLHVAR 14 0 Q9UM07 Q9UM07 PADI4 Protein-arginine deiminase type-4 0 120023200.0 33716000.0 55589200.0 30718000.0 False True 43646026.641719855 52495612.15316598 25127639.193296596 1.0 1.2027581017646882 0.5757142431214548 25.379346986904665 -6.81966683908023 1.3733478774736743 1.109324996479508 0.5621278244588565 0.8835933513086663 0.08913793720657272 0.19392636261016452 0.71879702083055 0.05100565835360183 0.11756851283119289 1.51472279421855e-07 6.81966683908023 -0.5471971720206515 DFGAGLK(ub)YNSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFGAGLKYNSR 11 1 Q9Y5Y6 Q9Y5Y6 ST14 Suppressor of tumorigenicity 14 protein 1 4549200.0 2117600.0 1141200.0 1290400.0 True False 2050377.9471156357 1596887.11127938 952405.5288297907 1.0 0.778825734799673 0.46450242511122636 20.967458436212027 -6.966138984941526 0.3379341498275371 1.0349191450494135 0.19799578837304532 0.9999347346238894 0.0017750074992349627 0.07757655355072007 0.013508705581122049 0.004465703909304476 0.027247633939618553 1.0810879211433447e-07 6.966138984941526 -0.8369233566763682 down DFGAGLK(ub)YNSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFGAGLKYNSR 11 1 Q9Y5Y6 Q9Y5Y6 ST14 Suppressor of tumorigenicity 14 protein 1 5760600.0 2117600.0 2558800.0 1084200.0 True False 1760878.225586157 2545015.2365179653 1310901.207225596 1.0 1.4453101864388076 0.7444587525575349 20.747863711646303 -6.735043268357843 1.7049795206674423 1.2664698138207917 0.7444867955429626 0.5824354908119981 0.18713503648791446 0.32685697991179197 1.8636348544650434 0.08690313930772843 0.21441264258153578 1.8405886161911562e-07 6.735043268357843 -0.5219830182778291 DFGAGLK(ub)YNSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFGAGLKYNSR 11 1 Q9Y5Y6 Q9Y5Y6 ST14 Suppressor of tumorigenicity 14 protein 1 3309300.0 1850900.0 1458400.0 0.0 True False 2396026.536693533 1377238.7579633656 0.0 1.0 0.5748011288155125 0.0 21.1922124558082 -7.7158761958434905 0.6427484611491788 1.0008873011904884 4.517882515007595e-19 0.9875617001484193 0.0457002786916724 0.1197135873628647 0.15184802005125494 0.042875793535255245 0.07789302606435762 1.9236400220572812e-08 7.7158761958434905 -1.0008873011904884 down DFGIQPVEDK(ub)GACR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFGIQPVEDKGACR 14 1 Q96GX2 Q96GX2 ATXN7L3B Putative ataxin-7-like protein 3B 1 37822700.0 3225700.0 5792000.0 28805000.0 True False 4893622.730258208 4758372.346897449 23111679.124319986 1.0 0.9723619104258938 4.722815876552159 22.222471451663907 -6.9052401207018255 0.9275535599761857 0.8656859234278544 5.16119962940466 0.9889976242908642 0.1847679142884554 0.10764999702503666 0.15646872316675112 0.1477984858927932 0.3957061656973056 1.2438267118846793e-07 6.9052401207018255 4.295513705976806 up DFGIQPVEDK(ub)GACR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFGIQPVEDKGACR 14 1 Q96GX2 Q96GX2 ATXN7L3B Putative ataxin-7-like protein 3B 1 45285200.0 3225700.0 7087500.0 34972000.0 True False 4175732.23805302 6693074.394586789 28607454.843022604 1.0 1.602850473407631 6.850883440831239 21.993597773756356 -6.928558502135869 0.758528694687242 0.9157789937336375 7.889774568685211 0.9962473108366998 0.1609641206868757 0.09339328658940636 0.08139725917028685 0.14540781842674766 0.4786758657580359 1.1788037204421454e-07 6.928558502135869 6.973995574951574 up DFGLLVFVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFGLLVFVR 9 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 24214700.0 3276700.0 7805000.0 13133000.0 False True 4970993.45885763 6412136.769256665 10537256.793601617 1.0 1.2899105223788043 2.119748674145943 22.24510277421808 -6.952501653366425 0.5306742625044217 0.9869752127476618 2.4603985378232167 0.9993832359423171 0.011784558060592958 0.0824965747567005 0.03192396925444722 0.013134390749242763 0.0686291498434228 1.11557390433408e-07 6.952501653366425 1.4734233250755548 up DFGLLVFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFGLLVFVR 9 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 10117800.0 3276700.0 2839500.0 4001600.0 False True 4241752.743413312 2681479.3288788954 3273349.8598833093 1.0 0.6321630446382703 0.7716974698646072 22.01622909631053 -10.025887294766068 5.720004416332265 1.0000007987078727 0.7019302582091035 0.8588431176880781 0.056964690559823894 5.802318511144693e-07 9.885665144926227e-08 0.05515597239834521 0.018385274821625632 9.421340612060612e-11 10.025887294766068 -0.29807054049876924 DFHILFVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFHILFVPR 9 0 H3BMM5;A0A2R8YF87;Q96AX1;F5H6Y0 H3BMM5 VPS33A Vacuolar protein sorting-associated protein 33A 0 9093300.0 2871000.0 2506200.0 3716100.0 False True 3763908.8028035527 2132284.729091087 3331593.6193482648 1.0 0.5665080746650534 0.8851419611619502 21.843800242200142 -9.958370614522119 6.702995939222023 1.0000000285752668 0.7258250179134997 0.49678244746489497 0.13008173944622303 5.559758443911017e-08 8.39990717762694e-09 0.1259511176447426 0.04198370087674162 1.1005996882973027e-10 9.958370614522119 -0.2741750106617671 DFHILFVPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFHILFVPR 9 0 H3BMM5;A0A2R8YF87;Q96AX1;F5H6Y0 H3BMM5 VPS33A Vacuolar protein sorting-associated protein 33A 0 5938500.0 2083500.0 1601800.0 2253200.0 False True 2017360.4329502413 2241407.0932766525 1663019.3254489203 1.0 1.1110593112995477 0.8243540907644733 20.94403743630654 -6.801642351921289 1.448978938001892 1.0611479006768483 0.8202233448622458 0.837003503487983 0.04765314890740043 0.21840610292371085 0.9050826903093518 0.025869311678297695 0.06010921706731984 1.5789109915532828e-07 6.801642351921289 -0.24092455581460248 DFHILFVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFHILFVPR 9 0 H3BMM5;A0A2R8YF87;Q96AX1;F5H6Y0 H3BMM5 VPS33A Vacuolar protein sorting-associated protein 33A 0 9021000.0 2871000.0 2770200.0 3379800.0 False True 3932486.2858577133 2647803.4041736308 2581560.849165961 1.0 0.6733153561643304 0.6564704010411819 21.907010303723034 -13.99999999999994 0.42277043687865745 7.380704406371258 0.6559821754831436 0.9998674994821167 0.0018200995037012443 30.44178170673554 0.2172283630707824 179.61013986078032 0.004058686785755037 1.000000000000139e-14 13.99999999999994 -6.724722230888115 DFHILFVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFHILFVPR 9 0 H3BMM5;A0A2R8YF87;Q96AX1;F5H6Y0 H3BMM5 VPS33A Vacuolar protein sorting-associated protein 33A 0 5249700.0 2083500.0 1266900.0 1899300.0 False True 1732522.5647000195 1260074.9582400396 2296434.848629009 1.0 0.7273065205117356 1.32548625652482 20.724442711740817 -6.782741375355505 1.5249581926023665 0.8461427340632486 1.330657492421685 0.7770311924326042 0.11546256146776858 0.24634617495222574 1.1316542652958748 0.059621551217279634 0.14037663381962276 1.6491441731833732e-07 6.782741375355505 0.4845147583584364 DFHILFVPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFHILFVPR 9 0 H3BMM5;A0A2R8YF87;Q96AX1;F5H6Y0 H3BMM5 VPS33A Vacuolar protein sorting-associated protein 33A 0 10788700.0 1949200.0 5524300.0 3315200.0 False True 2523277.824476222 5216867.848750026 2711867.6168245575 1.0 2.067496412065895 1.074740003070206 21.266867631733287 -6.628962322394745 2.08384366315067 1.703796262260115 1.078686830376457 0.11390542621178801 0.4580152423453693 0.5617053800291232 4.646686814006719 0.17983509677168308 0.507523856741298 2.3498366741826325e-07 6.628962322394745 -0.6251094318836581 DFIGVDSTGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFIGVDSTGKR 11 1 Q9NR50;Q9NR50-3;Q9NR50-2 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 5709300.0 1329600.0 1723200.0 2656500.0 True False 1743118.475864717 1466105.276980991 2381630.8629473546 1.0 0.8410818296522806 1.3663046407478916 20.733239198875943 -6.8255667707349845 1.347736123298046 0.9147908710028004 1.3791863330290013 0.8966754393103116 0.07069218531341298 0.1863558720445229 0.6635671968515239 0.0412023082266354 0.094848014780484 1.4942842855205896e-07 6.8255667707349845 0.46439546202620086 DFIGVDSTGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFIGVDSTGKR 11 1 Q9NR50;Q9NR50-3;Q9NR50-2 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 10547700.0 1467300.0 1660300.0 7420100.0 True False 1420721.3646594135 2323266.448350121 5476553.211771491 1.0 1.6352724088914314 3.8547693784307757 20.438192206775575 -6.947984940833263 0.5805443379947431 0.9735231919906949 4.62640122477732 0.999033518073551 0.03804623017092459 0.08430511409368882 0.0393898597515448 0.039839067963732815 0.18543492750954238 1.1272365424394332e-07 6.947984940833263 3.652878032786625 DFIGVDSTGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFIGVDSTGKR 11 1 Q9NR50;Q9NR50-3;Q9NR50-2 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 44726000.0 2037600.0 4502400.0 38186000.0 True False 3091188.168513539 3698911.5425882367 30638520.36248164 1.0 1.1965986348760302 9.911567556631404 21.559730046722716 -6.911762064471904 0.883635184994272 0.744970601237018 11.08139204827045 0.9915700188315891 0.38152680810498363 0.10326470927377066 0.132526927638496 0.3151080964649187 0.8808528002153608 1.225287309646238e-07 6.911762064471904 10.336421447033432 up DFIGVDSTGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFIGVDSTGKR 11 1 Q9NR50;Q9NR50-3;Q9NR50-2 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 4385800.0 1329600.0 0.0 3056200.0 True False 1821189.0510889636 0.0 2334388.504414765 1.0 0.0 1.2817936188551862 20.796449260398834 -6.6985536268332115 1.8361354419924794 0.378151674660001 1.2778629458552047 0.41063876302676616 0.4222267057622346 0.39855391881632407 2.611317610009024 0.18352760490779427 0.47281017922697843 2.0019184087471388e-07 6.6985536268332115 0.8997112711952037 DFIGVDSTGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFIGVDSTGKR 11 1 Q9NR50;Q9NR50-3;Q9NR50-2 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 8295100.0 1467300.0 1912800.0 4915000.0 True False 1220124.9624114893 1902495.3667389257 5942703.775607637 1.0 1.559262719269984 4.8705697848049185 20.21859748220985 -6.936116275689451 0.694751338040088 0.9591839434815487 5.669971919220506 0.9976097256726716 0.0835103654071325 0.08958384054235426 0.06301719861986857 0.07907229588118386 0.290206715901627 1.1584671528109386e-07 6.936116275689451 4.710787975738958 up DFIGVDSTGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFIGVDSTGKR 11 1 Q9NR50;Q9NR50-3;Q9NR50-2 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 27558000.0 2037600.0 2970400.0 22550000.0 True False 2637713.3671007324 2805094.628808544 18446131.38253917 1.0 1.063456956239256 6.993228154586945 21.330856368815166 -6.909239980223502 0.9009022506072226 0.8119605624873375 7.74720440263106 0.9906314154323534 0.2720224266165911 0.1049225428195051 0.14151204651078156 0.22187490322260295 0.6092918097956929 1.232423638690018e-07 6.909239980223502 6.935243840143722 up DFIHTASISFLTPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFIHTASISFLTPLR 15 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 0 29157600.0 7772000.0 12469700.0 8915900.0 False True 10189167.264155064 10609269.366509894 7993368.195351899 1.0 1.0412302685257437 0.784496709900144 23.280532812578304 -6.865757226057932 1.1562197192444523 1.0228179445983179 0.7706201724435622 0.9602667772847507 0.02243935456036329 0.14099247793816866 0.3549361342829079 0.015096697781557745 0.03550357933376548 1.3622059532303489e-07 6.865757226057932 -0.2521977721547557 DFIHTASISFLTPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFIHTASISFLTPLR 15 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 0 66830900.0 30407600.0 18059400.0 18363900.0 False True 29442327.38227869 25270612.59852688 13553843.684808893 1.0 0.8583089329322939 0.4603523189191538 24.811388383505815 -6.95292240265362 0.5257816958562036 1.0064726062408678 0.2942528250759211 0.9994111220436831 0.005543518011301779 0.08233302757257825 0.03126668084922705 0.006223833389963651 0.03289184711445669 1.1144936473903554e-07 6.95292240265362 -0.7122197811649467 down DFIHTASISFLTPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFIHTASISFLTPLR 15 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 0 139861100.0 43576100.0 55642000.0 40643000.0 False True 66108129.53963621 45712250.36706967 32609893.235540263 1.0 0.6914769890692815 0.49328113596057 25.978324359928543 -8.670329515454727 0.11940017974232163 1.5267801823194647 4.64769191479878e-11 0.9999501508600533 0.0014720462443147569 0.24020603236860547 0.03226392938732333 0.21345106169883102 0.17292184955064094 2.1363405529987723e-09 8.670329515454727 -1.5267801822729878 DFIHTASISFLTPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFIHTASISFLTPLR 15 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 0 62497700.0 7772000.0 22406400.0 32319300.0 False True 10645518.43040269 21416411.15994367 24686146.976877164 1.0 2.0117771905575053 2.3189238869171125 23.343742874101196 -10.37738607492966 0.26259285350112566 1.809457589959748e-25 2.4625936860575335 0.9991014752963675 0.016890553115395626 1.9440178228967522 0.12686732575833537 1.4479204942562995 0.13039650475615477 4.193859965003966e-11 10.37738607492966 2.4625936860575335 DFIHTASISFLTPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFIHTASISFLTPLR 15 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 0 55431600.0 30407600.0 12116000.0 12908000.0 False True 25285266.685083862 12050728.703162296 15607003.120151239 1.0 0.47659092756459603 0.6172370382535072 24.59179365894009 -10.402558154023868 8.957448401630602 1.0000020166296641 0.5469139829090945 0.9326013145161495 0.057418534249139216 2.3123754089881137e-06 1.542671449710402e-07 0.05559550350499054 0.018531752242546377 3.9576906599350183e-11 10.402558154023868 -0.4530880337205696 DFIHTASISFLTPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFIHTASISFLTPLR 15 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 0 139449100.0 43576100.0 62688000.0 33185000.0 False True 56410120.463348135 59199357.69281917 27145670.506854188 1.0 1.049445688230418 0.4812198641641227 25.749450682020992 -6.885713961252156 1.0474541424193513 1.0337418882475808 0.43627037604508084 0.9780082438128661 0.038112671471075776 0.12268746890757196 0.242739516797419 0.027869536962533817 0.06848617946179308 1.3010261889092977e-07 6.885713961252156 -0.5974715122025 down DFIIFEAAPQETR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFIIFEAAPQETR 13 0 H3BTA2;P60510 H3BTA2 PPP4C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 4 catalytic subunit 0 3123340.0 818640.0 1020600.0 1284100.0 False True 1073244.9677210383 868330.4582676407 1151233.6499569742 1.0 0.809070141844206 1.072666245434665 20.033547977552796 -6.712411738677523 1.7865697625218984 0.8829105201921195 1.0720928564862948 0.47654973559919833 0.08042721314441974 0.37025737894811306 2.3051643178888384 0.03580447256137705 0.09069645986482172 1.9390466668249383e-07 6.712411738677523 0.18918233629417536 DFIIFEAAPQETR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFIIFEAAPQETR 13 0 H3BTA2;P60510 H3BTA2 PPP4C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 4 catalytic subunit 0 3558940.0 818640.0 1303300.0 1437000.0 False True 1121313.3309141619 1245715.8965632415 1097610.1959439875 1.0 1.1109436249613291 0.9788612742605582 20.096758039075688 -6.68394827389571 1.8877838129032833 1.0699459688551816 0.9793469736092433 0.34225276176763564 0.04698070233221946 0.42984908708488273 2.9649810712669358 0.01994434622034737 0.05233874258181299 2.0703879250862853e-07 6.68394827389571 -0.09059899524593829 DFIILSCVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFIILSCVR 9 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 2677030.0 956040.0 707290.0 1013700.0 False True 1253377.6983045298 601765.088994826 908812.0480970205 1.0 0.48011472504165836 0.7250903293766832 20.257389797520144 -10.399084851835946 6.020182634424852 1.000095853099595 0.6026025272091722 0.7782053959358798 0.10001087167512616 0.0001286971748538567 1.2845930033001102e-05 0.09685829534694755 0.03227837003645414 3.98946949061752e-11 10.399084851835946 -0.39749332589042274 DFIK(ub)LEFPPGFPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFIKLEFPPGFPVK 14 1 Q8IZ07;H0YIN8;S4R3U2;F8W150 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 7317000.0 0.0 3969900.0 3347100.0 True False 0.0 5555101.7727550035 2470394.0991523536 0.0 DFIK(ub)LEFPPGFPVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFIKLEFPPGFPVK 14 1 Q8IZ07;H0YIN8;S4R3U2;F8W150 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 14070200.0 0.0 7746100.0 6324100.0 True False 0.0 6363747.934444467 5074138.863048509 0.0 DFIK(ub)LEFPPGFPVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFIKLEFPPGFPVK 14 1 Q8IZ07;H0YIN8;S4R3U2;F8W150 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 7294700.0 0.0 4910200.0 2384500.0 True False 0.0 4883747.778001615 2883087.9253176833 0.0 DFLAGGVAAAISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFLAGGVAAAISK 13 0 P05141 P05141 SLC25A5 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed 0 12915200.0 2655200.0 5783500.0 4476500.0 False True 3480992.912993375 4920624.343906426 4013314.721620119 1.0 1.4135691933009662 1.1529224051677227 21.731067446183896 -10.440642738488608 5.958409077000965 0.9998683914533151 1.2832457992343445 0.6115850566377392 0.10640860567029371 0.0001861201267331798 1.7472326256386454e-05 0.10307722336536443 0.03434322980451658 3.625411111749923e-11 10.440642738488608 0.2833774077810294 DFLAGGVAAAISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFLAGGVAAAISK 13 0 P05141 P05141 SLC25A5 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed 0 6591800.0 2655200.0 3936600.0 0.0 False True 3636899.1940819877 3762667.9954046286 0.0 1.0 1.0345813272821236 0.0 21.794277507706788 -6.998868109483135 1.1235682238285534 1.0334859976518318 7.613019575233298e-20 0.9830018386247089 0.06255008263631347 0.09225538922492858 0.22803247830544027 0.04686704961356973 0.08602085116203571 1.0026096735162325e-07 6.998868109483135 -1.0334859976518318 down DFLAMFSPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFLAMFSPK 9 0 O60711;O60711-2;B7Z5P7 O60711 LPXN Leupaxin 0 2665940.0 572780.0 841360.0 1251800.0 False True 750920.12680941 715832.367595593 1122275.7441134958 1.0 0.9532736466088588 1.4945341109472472 19.51829993506021 -6.88589369500845 1.0464147206909384 0.9679903454678619 1.5375004368672185 0.9781354203578667 0.03621009220524905 0.12253614329786469 0.24184044309745972 0.026499195049722948 0.06515539715529164 1.3004878676707705e-07 6.88589369500845 0.5695100913993566 DFLAMFSPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFLAMFSPK 9 0 O60711;O60711-2;B7Z5P7 O60711 LPXN Leupaxin 0 2178100.0 572780.0 748800.0 856520.0 False True 784552.2447974846 715715.5400495322 654227.6165831212 1.0 0.9122598842786803 0.8338866161194862 19.5815099965831 -6.972461080512927 0.19043452047373766 1.05281641713046 0.6911880693993285 0.9999957498564737 0.0001397624770949176 0.07551193809754965 0.006078356694446793 0.002756688209032958 0.008533293663639653 1.0654643414352773e-07 6.972461080512927 -0.3616283477311314 DFLDSLGFSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFLDSLGFSTR 11 0 P04818;P04818-2 P04818 TYMS Thymidylate synthase 0 9060900.0 1737800.0 3241500.0 4081600.0 False True 2278272.6288791397 2757880.8352680346 3659275.1854718314 1.0 1.2105139658482627 1.6061621155814503 21.119508966413093 -6.961242350033002 0.4175558634238755 0.9820446201556723 1.8494966554423151 0.9998135362520123 0.0034313012744553923 0.0792602718464138 0.01951332995950538 0.005110632049649575 0.03295742721928608 1.0933460743768367e-07 6.961242350033002 0.8674520352866428 DFLDSLGFSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFLDSLGFSTR 11 0 P04818;P04818-2 P04818 TYMS Thymidylate synthase 0 12494100.0 1737800.0 5441100.0 5315200.0 False True 2380311.6222791816 5200694.210688443 4059859.229980154 1.0 2.1848795603109754 1.7055998853178653 21.182719027935985 -10.336070474960064 5.288874957556251 0.9997088601033575 1.945239722814469 0.8383484337385915 0.1956651079701835 0.0006719057920326153 8.434681225309032e-05 0.1895078608948035 0.06315064205017516 4.6124272051258685e-11 10.336070474960064 0.9455308627111116 DFLEAVNK(ub)VIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFLEAVNKVIK 11 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 28526700.0 5535700.0 11870000.0 11121000.0 True False 5359972.233588977 16609752.901232263 8208076.477151363 1.0 3.098850549475806 1.5313654846408278 22.35379409639393 -6.571623348037189 2.300021844673234 2.4364061561515253 1.5347080439770393 0.0 0.9137359460660869 0.7249271308600193 7.201237125726822 0.3353662515466154 1.0237834579692444 2.68149290356826e-07 6.571623348037189 -0.901698112174486 DFLEAVNK(ub)VIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFLEAVNKVIK 11 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 29337700.0 5380300.0 8493400.0 15464000.0 True False 8162308.452617478 6977686.4107629135 12407533.621888032 1.0 0.8548667881480659 1.5201010466480473 22.960545800215847 -6.8495458274034995 1.2371953821354618 0.922576212215617 1.546474157102449 0.9396488198603222 0.0701618168859313 0.1579619868381382 0.46549107437353193 0.04437944707685214 0.10267262942315554 1.414015508165498e-07 6.8495458274034995 0.6238979448868319 DFLEAVNK(ub)VIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFLEAVNKVIK 11 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 22502100.0 5535700.0 9036400.0 7930000.0 True False 4603179.823090897 8987719.119615043 9588126.335822692 1.0 1.9525022842970448 2.0829354281850656 22.134199371828206 -10.891208761732136 0.37328203340812727 1.3259125152480969e-11 2.09937242789889 0.9993954754509491 0.011868264454708772 2.6153119539118115 0.1832237668654859 2.326656929285389 0.03597289168558696 1.2846689818434818e-11 10.891208761732136 2.0993724278856307 DFLEAVNK(ub)VIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFLEAVNKVIK 11 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 22445700.0 5380300.0 6979400.0 10086000.0 True False 6964904.411568538 6590990.254614314 8250451.49109933 1.0 0.9463145314193886 1.1845749781426331 22.731672122308296 -6.847512766050408 1.2469511990058686 0.9714000480199301 1.1936565281069245 0.936617152274036 0.02569072316200899 0.16021580824672865 0.48062728294334683 0.016131065781080617 0.037275579364508364 1.420650452343759e-07 6.847512766050408 0.2222564800869944 DFLK(ub)EFNNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFLKEFNNK 9 1 A0A5F9ZI01;A0A5F9ZH32;A0A5F9ZI39;P23458 A0A5F9ZI01 JAK1 Tyrosine-protein kinase JAK1 1 168441000.0 53291000.0 72420000.0 42730000.0 True False 69865017.07077804 61615218.290949084 38308709.495102756 1.0 0.8819180310015333 0.5483246279936268 26.058066911914793 -6.952792858509582 0.5272934028232612 1.0053656156645185 0.40980320359208383 0.9994026157767654 0.0046747741073370945 0.08238330677610559 0.031468433403241625 0.005236479651890213 0.02757704561678014 1.1148261352907619e-07 6.952792858509582 -0.5955624120724348 DFLK(ub)EFNNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFLKEFNNK 9 1 A0A5F9ZI01;A0A5F9ZH32;A0A5F9ZI39;P23458 A0A5F9ZI01 JAK1 Tyrosine-protein kinase JAK1 1 100930000.0 32547000.0 42254000.0 26129000.0 True False 31513813.300327044 59126242.55169907 19285031.04680225 1.0 1.8762008262289689 0.6119548549398214 24.909481001131574 -6.72032952692416 1.7586195853616922 1.5328969660971294 0.6139534842141612 0.5138670821198671 0.3686935126311052 0.35466891472298284 2.1439800213744813 0.1664709681696888 0.4176651778486447 1.9040154717495165e-07 6.72032952692416 -0.9189434818829683 DFLK(ub)EFNNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFLKEFNNK 9 1 A0A5F9ZI01;A0A5F9ZH32;A0A5F9ZI39;P23458 A0A5F9ZI01 JAK1 Tyrosine-protein kinase JAK1 1 160869000.0 79718000.0 47605000.0 33546000.0 True False 120938034.16645195 39109515.810437314 26915618.396265864 1.0 0.32338474889222435 0.2225571019223018 26.849692792553068 -13.999999999999998 0.26806205252057624 6.168448495329409 0.1884551110090708 0.9995791785607592 0.007081158028444466 14.788918131514238 0.1638820833760463 41.60615052878758 0.04228534561379796 1.0000000000000041e-14 13.999999999999998 -5.979993384320339 DFLK(ub)EFNNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFLKEFNNK 9 1 A0A5F9ZI01;A0A5F9ZH32;A0A5F9ZI39;P23458 A0A5F9ZI01 JAK1 Tyrosine-protein kinase JAK1 1 113247000.0 53291000.0 36256000.0 23700000.0 True False 72994122.8351247 34654090.037440985 18102548.116821505 1.0 0.47475178399932044 0.2480000774543259 26.121276973437684 -10.871605019072518 0.16831285185746184 1.9507556790293124 1.607183240040056e-09 0.9995579129894528 0.006622332546015792 2.915537766656351 0.09388711928950945 1.2683588679099302 0.17736951689524535 1.343986730750703e-11 10.871605019072518 -1.950755677422129 DFLK(ub)EFNNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFLKEFNNK 9 1 A0A5F9ZI01;A0A5F9ZH32;A0A5F9ZI39;P23458 A0A5F9ZI01 JAK1 Tyrosine-protein kinase JAK1 1 104123000.0 32547000.0 51289000.0 20287000.0 True False 27064272.57657377 51012695.976930596 24528917.90351012 1.0 1.8848722363624895 0.9063209747873218 24.68988627656585 -6.668561273154262 1.9426571984086778 1.5655084807069133 0.9103143863535582 0.27264993252921677 0.37599948798977106 0.4644043349832686 3.377556677443944 0.15590172031357408 0.41728534530599004 2.145056455632726e-07 6.668561273154262 -0.6551940943533551 DFLK(ub)EFNNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFLKEFNNK 9 1 A0A5F9ZI01;A0A5F9ZH32;A0A5F9ZI39;P23458 A0A5F9ZI01 JAK1 Tyrosine-protein kinase JAK1 1 139722000.0 79718000.0 43302000.0 16702000.0 True False 103196522.4767061 40892205.63448281 13662407.376991978 1.0 0.3962556552592472 0.13239212959017982 26.620819114645517 -9.338718664318893 0.2716385192663194 1.353028248014355 1.3529332434937629e-25 0.9988941277403974 0.012076291778256391 0.7474478616901534 0.10466488069566235 0.341517789568135 0.1014195667347177 4.584387668778732e-10 9.338718664318893 -1.353028248014355 DFLLK(ub)PELLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFLLKPELLR 10 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8;Q13838-2;Q13838;Q5STU3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;F6R6M7;A0A0G2JHN7;F6SXL5;F6S2B7;F6U6E2;F6QYI9;A0A0G2JJL7 O00148;Q13838-2;F6QYI9 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 1 32715300.0 7533300.0 12461600.0 12720400.0 True False 9876229.252580972 10602377.85493634 11404215.030692829 1.0 1.0735248832104218 1.154713478093124 23.235528894841217 -6.969848556447951 0.26177958134675416 0.9776958187641289 1.252956893229182 0.9999811685409017 0.00027414211137795857 0.07635185582444176 0.009205899059816286 0.0016755493888076984 0.007640007148120393 1.0718930216748751e-07 6.969848556447951 0.275261074465053 DFLLK(ub)PELLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFLLKPELLR 10 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8;Q13838-2;Q13838;Q5STU3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;F6R6M7;A0A0G2JHN7;F6SXL5;F6S2B7;F6U6E2;F6QYI9;A0A0G2JJL7 O00148;Q13838-2;F6QYI9 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 1 41576600.0 8864500.0 9559000.0 23153100.0 True False 8583101.299681976 13375958.549526477 17088608.531888608 1.0 1.558406231325976 1.9909596700812304 23.033067594816576 -6.973977785909424 0.13222866882056655 0.3515916274695659 3.2089883699236217 0.9999991609026534 0.00037153389793973636 0.07503174343426976 0.003977161896880406 0.026560135333141523 0.058441213341590206 1.0617498641389201e-07 6.973977785909424 2.8573967424540556 DFLLK(ub)PELLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFLLKPELLR 10 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8;Q13838-2;Q13838;Q5STU3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;F6R6M7;A0A0G2JHN7;F6SXL5;F6S2B7;F6U6E2;F6QYI9;A0A0G2JJL7 O00148;Q13838-2;F6QYI9 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 1 127667100.0 19728000.0 19883100.0 88056000.0 True False 29928818.30998974 16334805.45763063 70651693.00368407 1.0 0.5457885202296259 2.3606576200872493 24.835031981738723 -6.840422042914372 1.2804287526990836 0.7583841435540005 2.4208528012760193 0.9251804147340913 0.21092206317385337 0.16830440860401186 0.5358228409665147 0.12915904634341657 0.29759258408760486 1.4440357895289092e-07 6.840422042914372 1.6624686577220187 up DFLLK(ub)PELLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFLLKPELLR 10 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8;Q13838-2;Q13838;Q5STU3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;F6R6M7;A0A0G2JHN7;F6SXL5;F6S2B7;F6U6E2;F6QYI9;A0A0G2JJL7 O00148;Q13838-2;F6QYI9 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 1 31307400.0 7533300.0 9717600.0 14056500.0 True False 10318564.589777736 9288244.300194083 10736644.202704705 1.0 0.9001488743304125 1.040517225946441 23.298738956364108 -6.715645735803076 1.7747693361412 0.9389726018913561 1.040250222434484 0.49202201196049933 0.04204153421989548 0.36383124051298754 2.2371496780706717 0.01882586045736364 0.0475075176424489 1.9246610799380953e-07 6.715645735803076 0.10127762054312794 DFLLK(ub)PELLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFLLKPELLR 10 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8;Q13838-2;Q13838;Q5STU3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;F6R6M7;A0A0G2JHN7;F6SXL5;F6S2B7;F6U6E2;F6QYI9;A0A0G2JJL7 O00148;Q13838-2;F6QYI9 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 1 35052500.0 8864500.0 11299800.0 14888200.0 True False 7371224.513934874 11238925.734565312 18001253.784740936 1.0 1.5247026750194317 2.442098154887374 22.813472870250852 -6.96258626819048 0.3973072449022039 0.9480471629946537 3.052106011374309 0.9998544208808009 0.007190689916041143 0.0787898707631054 0.01781013620058274 0.011809985442538543 0.07694133743636253 1.0899679598084535e-07 6.96258626819048 2.104058848379655 DFLLK(ub)PELLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFLLKPELLR 10 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8;Q13838-2;Q13838;Q5STU3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;F6R6M7;A0A0G2JHN7;F6SXL5;F6S2B7;F6U6E2;F6QYI9;A0A0G2JJL7 O00148;Q13838-2;F6QYI9 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 1 118241100.0 19728000.0 22781100.0 75732000.0 True False 25538284.89701769 21513311.75880368 61949553.07594035 1.0 0.8423945400231619 2.4257522901694424 24.606158303831172 -6.88241584729244 1.0662701715219352 0.8988233309352109 2.5432781690322193 0.9755809562441238 0.11128737568990289 0.1255100125034563 0.2595565697792434 0.08021848670071237 0.19523004758354065 1.3109440377707832e-07 6.88241584729244 1.6444548380970083 up DFLLKPELLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFLLKPELLR 10 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8;Q13838-2;Q13838;Q5STU3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;F6R6M7;A0A0G2JHN7;F6SXL5;F6S2B7;F6U6E2;F6QYI9;A0A0G2JJL7 O00148;Q13838-2;F6QYI9 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 33100500.0 6752300.0 12379600.0 13968600.0 False True 8852330.689366223 10532611.935302848 12523263.268272687 1.0 1.1898122997093914 1.414685432314016 23.077625915062917 -6.968881597543332 0.28362792002769643 0.9525741639303338 1.6588101392137404 0.9999722968714908 0.0008921035514992483 0.07666728222988446 0.010322993525509307 0.004068771672289918 0.020547694770016094 1.0742822558519596e-07 6.968881597543332 0.7062359752834066 DFLLKPELLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFLLKPELLR 10 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8;Q13838-2;Q13838;Q5STU3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;F6R6M7;A0A0G2JHN7;F6SXL5;F6S2B7;F6U6E2;F6QYI9;A0A0G2JJL7 O00148;Q13838-2;F6QYI9 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 36889900.0 6752300.0 11660000.0 18477600.0 False True 9248807.784046337 11144822.645536259 14113571.438117353 1.0 1.205001001832954 1.5259881887114635 23.14083597658581 -6.964534366886765 0.3659604562797872 0.9741572693327509 1.767934382602475 0.9999032161140928 0.0021295688319606836 0.07811938009030206 0.015419580754221783 0.004258655144875597 0.027321766775614452 1.0850896801795963e-07 6.964534366886765 0.793777113269724 DFLLQQTMLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFLLQQTMLR 10 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 33504500.0 8445500.0 11180000.0 13879000.0 False True 11072132.286338346 9511987.579298684 12442934.216768809 1.0 0.8590926601405685 1.1238064986020682 23.400429749266316 -6.762093627630573 1.6044991021890485 0.9183657080319406 1.1248776305960624 0.6994689334168142 0.059285374864701125 0.2794256592022333 1.4182228169442543 0.029146347291601222 0.06990176613383985 1.7294434759364225e-07 6.762093627630573 0.20651192256412176 DFLLQQTMLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFLLQQTMLR 10 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 31477400.0 16190000.0 3622400.0 11665000.0 False True 15676057.311957931 5068843.21056645 8609586.557501169 1.0 0.3233493671077523 0.5492188747570887 23.902059416793918 -10.29209662084929 5.18318355777537 1.0001207437881938 0.4362841209324637 0.8925318746001049 0.09221084036605924 0.0001286884707487558 1.7575788057148055e-05 0.08930169745859619 0.029760920756417886 5.1039143661639156e-11 10.29209662084929 -0.5638366228557301 DFLLQQTMLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFLLQQTMLR 10 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 29696100.0 8445500.0 8193600.0 13057000.0 False True 11568029.581055835 7831579.659388137 9973205.517356055 1.0 0.6770020429592759 0.8621352018055423 23.463639810789207 -10.187300960490203 5.258385807130371 1.0000122759772045 0.7695686234502866 0.6738032864876236 0.07558029560745942 1.0877828057985607e-05 1.681182087112605e-06 0.07318420349881662 0.0243934355157176 6.496793148996598e-11 10.187300960490203 -0.2304436525269179 DFLLQQTMLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFLLQQTMLR 10 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 24740500.0 16190000.0 3657300.0 4893200.0 False True 13462702.33860968 3637597.39898279 5916345.496399454 1.0 0.2701981598858147 0.43946195552671236 23.682464692228194 -10.503013871459801 9.308922188950982 1.000015249967798 0.3548300577216217 0.9509113383929518 0.06910165520782113 2.187102219720166e-05 1.1676735978002455e-06 0.06690896403815283 0.0223024633179382 3.140408386950358e-11 10.503013871459801 -0.6451851922461762 DFLLTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFLLTAR 7 0 P63173;J3KT73;J3QL01;J3KSP2 P63173 RPL38 60S ribosomal protein L38 0 11815900.0 2497200.0 3265200.0 6053500.0 False True 3273853.3829192016 2778044.8876499105 5427141.889272281 1.0 0.8485550703473492 1.6577229504496176 21.64255828256209 -6.858341551733458 1.194264639997209 0.9181762330029705 1.6956481886516594 0.9515680229083692 0.07729699461011548 0.14852589960894733 0.40350696484444404 0.05051692775851381 0.11769647515325794 1.385665640820346e-07 6.858341551733458 0.777471955648689 DFLLTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFLLTAR 7 0 P63173;J3KT73;J3QL01;J3KSP2 P63173 RPL38 60S ribosomal protein L38 0 8185800.0 2497200.0 2387300.0 3301300.0 False True 3420482.324292538 2281821.1922546015 2521600.9324077168 1.0 0.6671050968598567 0.7372062455926481 21.70576834408498 -10.07599980863696 5.046383396533644 1.0000064733625076 0.7021556712250846 0.960110896216912 0.02861867413377608 2.084351139299666e-06 3.816387302335295e-07 0.027710514359302385 0.009236637358639114 8.394603564104677e-11 10.07599980863696 -0.297850802137423 DFLLTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFLLTAR 7 0 P63173;J3KT73;J3QL01;J3KSP2 P63173 RPL38 60S ribosomal protein L38 0 4389290.0 2075300.0 1316300.0 997690.0 False True 1725703.901378424 1309208.8306349064 1206302.3662026415 1.0 0.7586520663186554 0.6990204781011939 20.718753515498673 -13.999999999877001 0.19634796127121476 2.3234130494980394 0.6588690390148735 0.99948714972158 0.002946838420442127 12.460998336840019 0.14051489899621036 6.323913798389685 0.039030698519852636 1.0000000002832145e-14 13.999999999877001 -1.664544010483166 DFLTGMCLFLQSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFLTGMCLFLQSLR 14 0 Q9Y5P6;Q9Y5P6-2 Q9Y5P6 GMPPB Mannose-1-phosphate guanyltransferase beta 0 1001690000.0 455470000.0 293210000.0 253010000.0 False True 690981289.3172655 240884384.63981354 203002462.60177743 1.0 0.34861202229921884 0.29378865352831346 29.364071404336652 -13.999999999999998 0.3505894047782957 9.039789839813507 0.2862733395005919 0.9997558306679282 0.0050123383600146594 20.718832924600076 0.19064772380874864 124.08806805819675 0.01632455448054737 1.0000000000000041e-14 13.999999999999998 -8.753516500312914 DFLTGMCLFLQSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFLTGMCLFLQSLR 14 0 Q9Y5P6;Q9Y5P6-2 Q9Y5P6 GMPPB Mannose-1-phosphate guanyltransferase beta 0 632794000.0 455470000.0 28884000.0 148440000.0 False True 589614893.6559528 27276580.008923393 121425443.12302046 1.0 0.04626168759034027 0.20594025766566476 29.1351977264291 -10.232620225690068 5.46967842304067 1.0000554805377835 0.1261009726302005 0.9755718112191148 0.0651885032571845 4.4106475821767534e-05 6.188155647251037e-06 0.0631224726561128 0.02103949895657355 5.853016848950584e-11 10.232620225690068 -0.873954507907583 DFLTPPLLSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFLTPPLLSVR 11 0 O95782;O95782-2 O95782 AP2A1 AP-2 complex subunit alpha-1 0 2571470.0 633830.0 1030100.0 907540.0 False True 830957.2680184515 876413.0952983507 813636.4665383945 1.0 1.0547029661203828 0.9791556050513148 19.6644147627405 -6.71242804383688 1.7861837641388438 1.033545051140688 0.9793170002570705 0.47683503500339885 0.02304283280777106 0.37019469890699186 2.3037164215977897 0.01025965010278562 0.025991452785388718 1.9389738685907368e-07 6.71242804383688 -0.054228050883617596 DFLTPPLLSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFLTPPLLSVR 11 0 O95782;O95782-2 O95782 AP2A1 AP-2 complex subunit alpha-1 0 3545830.0 633830.0 1415800.0 1496200.0 False True 868174.0796117007 1353245.27457549 1142828.3752062586 1.0 1.5587257283478702 1.3163585530189978 19.72762482426339 -10.11916934378303 4.542535097257652 0.9999575049059326 1.4375421406954336 0.8129236625544791 0.09894598503697487 69005678.00336441 3.1705824778585843 31492.979183165233 0.03387184248042527 7.600298618721055e-11 10.11916934378303 0.437584635789501 DFLVQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFLVQIK 7 0 O14980 O14980 XPO1 Exportin-1 0 14848300.0 4512600.0 3467800.0 6867900.0 False True 5916062.300080564 2950417.7573785293 6157275.589548702 1.0 0.4987130979567864 1.0407726080681832 22.49620581438185 -11.983815278216346 14.572444160744547 0.9032127594581836 0.7927685707515802 0.0 0.25226935926653693 0.0 0.0 0.0 0.07339172851166159 1.0379698095547022e-12 11.983815278216346 -0.11044418870660333 DFLVQIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFLVQIK 7 0 O14980 O14980 XPO1 Exportin-1 0 12636700.0 2970300.0 1622200.0 8044200.0 False True 2876009.452360017 2269952.919661247 5937182.699172818 1.0 0.7892717173785894 2.0643821925900974 21.455636986704484 -6.864455996029366 1.16294587842231 0.8839986288573918 2.1316178199197555 0.9588341147500106 0.11323384799037922 0.14228559983669015 0.36315353019231894 0.07578990235196227 0.17791005792683948 1.3662935054794492e-07 6.864455996029366 1.2476191910623637 up DFLVQIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFLVQIK 7 0 O14980 O14980 XPO1 Exportin-1 0 18263700.0 4512600.0 4398800.0 9352300.0 False True 6181030.168429642 4204446.471113626 7143479.356664552 1.0 0.6802177560284924 1.1557101586642848 22.55941587590474 -6.725485902402659 1.7393738944300485 0.8066002509272534 1.1552189204988925 0.5383675771574965 0.13448308345804819 0.34476182128491273 2.041189872199869 0.06132049445684044 0.15296478512062053 1.881542781832052e-07 6.725485902402659 0.3486186695716391 DFLYSYFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFLYSYFK 8 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 8183600.0 2527200.0 2181000.0 3475400.0 False True 3313183.6734396103 1855603.3014714157 3115798.946390826 1.0 0.5600665355039025 0.9404244537871129 21.65978675385247 -10.164660215194418 7.661757525717236 1.0000000993899447 0.7502454946455077 0.3650327343806823 0.15528046990351438 2.6349940502631526e-07 2.8948743248153457e-08 0.15034972673144456 0.050116556160631105 6.844469377944947e-11 10.164660215194418 -0.249754604744437 DFLYSYFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFLYSYFK 8 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 7621000.0 1968700.0 1078800.0 4573500.0 False True 1906204.696111897 1509570.4658676789 3375563.1479409914 1.0 0.7919246390205436 1.7708293106328812 20.862271619426664 -6.851139479472972 1.2295434467246948 0.8888442803247353 1.8108386219187298 0.9419520034129482 0.10144992547057124 0.15620786801216105 0.4538562592587107 0.06454401365053566 0.14947474758447382 1.4088362591762657e-07 6.851139479472972 0.9219943415939945 DFLYSYFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFLYSYFK 8 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 8092700.0 2527200.0 2652500.0 2913000.0 False True 3461574.1350120497 2535303.7793554766 2225009.3951181895 1.0 0.7324135438014102 0.6427738677075724 21.72299681537536 -13.999999999999998 0.15277107542827473 2.2997256886198008 0.5472266977711239 0.9995572540708157 0.0031930138678072408 11.969215437424703 0.12323247406530197 4.614696420718451 0.08636116974566421 1.0000000000000041e-14 13.999999999999998 -1.752498990848677 DFLYSYFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFLYSYFK 8 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 4962900.0 1968700.0 1444700.0 1549500.0 False True 1637061.278197709 1436917.1143495017 1873493.2859214707 1.0 0.8777418008026234 1.1444246534155746 20.64267689486094 -6.7820699261253745 1.5279379922742173 0.9309600841900663 1.1466708728428916 0.774599735868467 0.051748310493941005 0.24737361257062102 1.1408456779851903 0.02667238926048461 0.06282413989180653 1.6516958358612635e-07 6.7820699261253745 0.21571078865282534 DFMIQGGDFTR ddPTM_RPMI8226_Bortezomib_1h_R1 2 DFMIQGGDFTR 11 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 511713000.0 129460000.0 161776000.0 220477000.0 False True 169723313.69242322 137639651.39790893 197664155.0047218 1.0 0.8109649075514923 1.1646258295600664 27.33860951041594 -6.761536019075992 1.6069881585166659 0.8904060990214765 1.1660033270290913 0.6970933576130216 0.07952622629439346 0.2803443137938375 1.4272496434098225 0.039042247365992724 0.09367166385660942 1.731665405682276e-07 6.761536019075992 0.27559722800761477 DFMIQGGDFTR ddPTM_RPMI8226_Bortezomib_2h_R1 2 DFMIQGGDFTR 11 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 392387300.0 115324100.0 58209200.0 218854000.0 False True 111663199.57072069 81452437.11696796 161529571.92073387 1.0 0.7294474583399425 1.4465783941506247 26.734578559562053 -6.8044739494567485 1.437410066399989 0.8515614738591634 1.4576270323741878 0.8449759166414366 0.11642338805458885 0.2144253751182305 0.8741060269972496 0.06370324049635492 0.14777652772005775 1.5686499881200717e-07 6.8044739494567485 0.6060655585150244 DFMIQGGDFTR ddPTM_RPMI8226_Bortezomib_8h_R1 2 DFMIQGGDFTR 11 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 443033100.0 31081800.0 361819000.0 50132300.0 False True 47153362.98395373 297249572.54524964 40223628.93123237 1.0 6.303889133981887 0.8530383918729286 25.490857331978386 -6.652445458887785 2.000275172260377 4.435091580744039 0.8761484476912024 0.2038870485022729 2.262416766465235 0.5025331589714775 3.856946991812374 0.916520591056596 2.505550014318767 2.226150599590371e-07 6.652445458887785 -3.558943133052837 DFMIQGGDFTR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DFMIQGGDFTR 11 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 477325000.0 129460000.0 156643000.0 191222000.0 False True 177324860.52495253 149721994.31086904 146059301.94071054 1.0 0.8443373019870538 0.823682034816306 27.40181957193883 -13.999999997131857 0.28466495440903744 2.301844701875077 0.8177445945837538 0.9996155370444535 0.0015431495700369343 15.65648556152791 0.16909293033653036 11.898894197829733 0.007993876298593234 1.0000000066041434e-14 13.999999997131857 -1.4841001072913234 DFMIQGGDFTR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DFMIQGGDFTR 11 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 254868500.0 115324100.0 72010000.0 67534400.0 False True 95897098.87387627 71622067.8371342 81655530.7962149 1.0 0.7468637599906066 0.8514911478563927 26.51498383499633 -10.063600439062865 6.281651023621098 1.0000002634311247 0.7991774539767642 0.8308572092841808 0.04271395223191562 1.5756619557992004e-07 2.3496780502778248e-08 0.041357660642989645 0.01378586880374104 8.637728732719814e-11 10.063600439062865 -0.20082280945436048 DFMIQGGDFTR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DFMIQGGDFTR 11 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 222519600.0 31081800.0 129529000.0 61908800.0 False True 40236002.81387492 122320597.28485803 50642033.63793076 1.0 3.0400782565478193 1.2586248657003134 25.261983654070836 -6.613358298126156 2.1408677157170812 2.359866893507545 1.2651143492893662 0.06105729325911935 0.878787856524291 0.6034715566599557 5.245940893489696 0.3383605964494922 0.9753771346976006 2.4358004247881847e-07 6.613358298126156 -1.094752544218179 DFMVQGGDFSEGNGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFMVQGGDFSEGNGR 15 0 C9JN15;Q13427-2;Q13427;C9JM79 C9JN15 PPIG Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase G 0 4753000.0 0.0 2112400.0 2640600.0 False True 0.0 1797238.1540707105 2367376.042423785 0.0 DFMVQGGDFSEGNGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFMVQGGDFSEGNGR 15 0 C9JN15;Q13427-2;Q13427;C9JM79 C9JN15 PPIG Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase G 0 2464400.0 0.0 1096600.0 1367800.0 False True 0.0 1048148.5860287347 1044753.8107252511 0.0 DFNHINVELSLLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFNHINVELSLLGK 14 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7 P32969 RPL9 60S ribosomal protein L9 0 8848300.0 5061600.0 2491100.0 1295600.0 False True 6635806.616604132 2119437.5902317446 1161543.7402727637 1.0 0.31939411629755493 0.17504183099102769 22.661840412620446 -13.999999999999982 0.21795175189007585 5.070576048660501 0.09629556497065601 0.9994959253934652 0.008076399265733416 12.944697739079631 0.1479121287587492 22.6543432080973 0.08098118036533297 1.0000000000000409e-14 13.999999999999982 -4.974280483689846 DFNHINVELSLLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFNHINVELSLLGK 14 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7 P32969 RPL9 60S ribosomal protein L9 0 75060000.0 28335000.0 16914000.0 29811000.0 False True 27435520.934794813 23667848.405344788 22002604.789169934 1.0 0.8626717335382644 0.801975105246329 24.709541633600878 -13.999999999988443 0.11073793764465399 1.6617884661692637 0.691803026393647 0.9997393116261626 0.0013374532182651 12.008346443472684 0.10110013577763925 1.7743926859033037 0.097838301060889 1.000000000026611e-14 13.999999999988443 -0.9699854397756167 DFNHINVELSLLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFNHINVELSLLGK 14 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7 P32969 RPL9 60S ribosomal protein L9 0 1003160000.0 319080000.0 386250000.0 297830000.0 False True 484067687.87264395 317320669.7149756 238963769.95647398 1.0 0.6555295419727772 0.49365775891107255 28.85063355480207 -13.999999999999973 0.10068692095827739 2.697808064065265 0.15253034840685306 0.9997902713695165 0.0030578174850380744 12.075214373776438 0.09463603187006378 4.252530128918556 0.3041223436500116 1.0000000000000614e-14 13.999999999999973 -2.5452777156584117 DFNHINVELSLLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFNHINVELSLLGK 14 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7 P32969 RPL9 60S ribosomal protein L9 0 19299900.0 5061600.0 4776000.0 9462300.0 False True 6933010.304596796 4564980.527880029 7227499.622185667 1.0 0.6584413302910149 1.0424763998105724 22.725050474143337 -6.672088341816538 1.9300380074179073 0.7823773536135655 1.0409371524784488 0.28832472278598564 0.1450171204101242 0.4563254721347412 3.2791057111364768 0.060447703194786165 0.1610586202737408 2.1277061955621868e-07 6.672088341816538 0.25855979886488323 DFNHINVELSLLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFNHINVELSLLGK 14 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7 P32969 RPL9 60S ribosomal protein L9 0 83908000.0 28335000.0 28219000.0 27354000.0 False True 23561807.953335725 28066978.64596705 33073594.929394 1.0 1.1912064940667473 1.4036951236889976 24.489946909035154 -6.969762830763683 0.26378829437984647 0.9430363664409811 1.658200867202975 0.999980472571816 0.0007285977778192029 0.07637974179514687 0.009305103624454726 0.004329560488063342 0.019936895350734014 1.0721046242536867e-07 6.969762830763683 0.715164500761994 DFNHINVELSLLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFNHINVELSLLGK 14 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7 P32969 RPL9 60S ribosomal protein L9 0 776430000.0 319080000.0 250840000.0 206510000.0 False True 413055350.0071168 236880533.49391854 168927298.97153702 1.0 0.5734837558449181 0.4089701270510755 28.62175987689452 -13.999999999999998 0.13189055610923786 3.027695717672009 0.1840176515293006 0.9996371429056892 0.004744374238019121 11.934276588526165 0.11311914264329123 6.262983531762755 0.2002085101084894 1.0000000000000041e-14 13.999999999999998 -2.8436780661427083 DFNHINVELSLLGKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFNHINVELSLLGKK 15 1 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7 P32969 RPL9 60S ribosomal protein L9 1 30298800.0 10938000.0 15987000.0 3373800.0 True False 10590779.177158494 22370692.471103642 2490100.568169522 1.0 2.1122801350963205 0.2351196759479236 23.33630539836428 -6.746165641951085 1.663794941225934 1.657052515459242 0.23240957381483876 0.6323220594300678 0.467330998082504 0.3068250861023002 1.6698210498034773 0.22198905134231212 0.5411676992672294 1.7940492375376612e-07 6.746165641951085 -1.424642941644403 DFNHINVELSLLGKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFNHINVELSLLGKK 15 1 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7 P32969 RPL9 60S ribosomal protein L9 1 25841900.0 9562500.0 5881400.0 10398000.0 True False 14507011.612392372 4831818.218412062 8342830.7423947025 1.0 0.3330677845659517 0.575089547406716 23.790247024690622 -10.23174098307173 5.497841759407395 1.0000326109582989 0.4540786659863998 0.8715324262519635 0.09880497093491229 3.9496854604387544e-05 5.519340188247108e-06 0.09567319963304813 0.031889167246101226 5.864878465743076e-11 10.23174098307173 -0.5459539449718991 DFNHINVELSLLGKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFNHINVELSLLGKK 15 1 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7 P32969 RPL9 60S ribosomal protein L9 1 30363600.0 10938000.0 18375000.0 1050600.0 True False 9095431.635559779 18276010.22784808 1270275.6025744416 1.0 2.0093615080779266 0.13966083782193833 23.116710673798558 -6.760085342431661 1.612202553430062 1.5862312184970537 0.1328124175920333 0.6913019267012277 0.4245440472907358 0.2827707267178927 1.4485980203019562 0.20777118789539195 0.4992541410041113 1.73745937016835e-07 6.760085342431661 -1.4534188009050204 DFNTNK(ub)CK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFNTNKCK 8 1 Q15717;Q15717-2;P26378;A0A494C0F8;A0A494C147;A0A0A0MRX1;A0A494C015;A0A0R4J2E6;Q12926-2;B1APY9;Q12926;P26378-4;P26378-2;P26378-5;P26378-1;P26378-3;A0A494C1D9 Q15717 ELAVL1;ELAVL4;ELAVL2 ELAV-like protein 1;ELAV-like protein 4;ELAV-like protein;ELAV-like protein 2 1 9791200.0 3666900.0 4209800.0 1914500.0 True False 4807341.4103101175 3581714.249671877 1716405.9051807688 1.0 0.7450509427082325 0.3570384873226728 22.19680783451639 -6.965015057044094 0.3577952258043004 1.0342885376890205 0.05454960594607286 0.9999134534198739 0.002459298940098379 0.07795587114519997 0.014842025282439176 0.005229737791519606 0.03318540270821357 1.0838893347907469e-07 6.965015057044094 -0.9797389317429477 down DFNTNK(ub)CK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFNTNKCK 8 1 Q15717;Q15717-2;P26378;A0A494C0F8;A0A494C147;A0A0A0MRX1;A0A494C015;A0A0R4J2E6;Q12926-2;B1APY9;Q12926;P26378-4;P26378-2;P26378-5;P26378-1;P26378-3;A0A494C1D9 Q15717 ELAVL1;ELAVL4;ELAVL2 ELAV-like protein 1;ELAV-like protein 4;ELAV-like protein;ELAV-like protein 2 1 7442400.0 3666900.0 2131600.0 1643900.0 True False 5022652.024246481 2037418.8637414281 1255644.6771832427 1.0 0.4056460319978249 0.24999635075687324 22.260017896039283 -13.999999999999998 0.18809574413985447 4.165417427151742 0.1361667667982677 0.9994905686653902 0.007294286337461993 12.320322333188335 0.13753169339479848 14.284658973271204 0.10868576052017853 1.0000000000000041e-14 13.999999999999998 -4.029250660353474 DFPSFAQLTMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFPSFAQLTMK 11 0 P53602 P53602 MVD Diphosphomevalonate decarboxylase 0 7064900.0 2374700.0 2002100.0 2688100.0 False True 3113254.696627514 1703394.4841246756 2409961.1980759585 1.0 0.547142669043399 0.7740970247909976 21.569992178425014 -10.243018081331357 4.774228158174572 1.000082542775607 0.6606198469164252 0.7488382732262976 0.09265372774999495 8.142446077603956e-05 1.2910428048174054e-05 0.08973332954123668 0.029903862044595705 5.714548443375786e-11 10.243018081331357 -0.3394626958591819 DFPSFAQLTMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFPSFAQLTMK 11 0 P53602 P53602 MVD Diphosphomevalonate decarboxylase 0 6385800.0 2374700.0 1989900.0 2021200.0 False True 3252690.7638545134 1901979.6382806678 1543834.1879206614 1.0 0.5847403815377697 0.474632942386193 21.633202239947906 -13.999999999999998 0.1863316716859093 3.1985637336373722 0.3926575199414208 0.9994918504980518 0.0050994610497439455 12.293273333418933 0.13687990073780792 9.801548612782089 0.07799127949698417 1.0000000000000041e-14 13.999999999999998 -2.8059062136959514 DFPSFAQLTMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFPSFAQLTMK 11 0 P53602 P53602 MVD Diphosphomevalonate decarboxylase 0 4007710.0 2091200.0 818510.0 1098000.0 False True 1738925.4558678544 814100.524168485 1327586.723421605 1.0 0.4681629804321817 0.7634523486569121 20.729764657946337 -10.141666492961859 5.466187450590101 1.0000078115434352 0.6158076645444641 0.6929733736753065 0.12055137977020848 1.1476335923573907e-05 1.802329985618911e-06 0.11672574285315034 0.03890779051765063 7.216614507263341e-11 10.141666492961859 -0.3842001469989711 DFQK(ub)DFVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFQKDFVK 8 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;P78347-5;C9J6M0 A0A494C1K3 GTF2I General transcription factor II-I 1 7492700.0 3074800.0 1395000.0 3022900.0 True False 2977192.1570604276 1952030.774828895 2231111.804943875 1.0 0.6556616677226034 0.7494013443683106 21.50552090984252 -10.065846624642989 7.123872628185392 1.0000000658644872 0.7025315060454577 0.9306847455647635 0.03826906273924552 4.0042973522282955e-08 5.192929505644554e-09 0.0370538689481568 0.012351286888672031 8.593169441332137e-11 10.065846624642989 -0.29746855981902953 DFQK(ub)DFVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFQKDFVK 8 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;P78347-5;C9J6M0 A0A494C1K3 GTF2I General transcription factor II-I 1 7188000.0 3074800.0 2142900.0 1970300.0 True False 2556832.4367360785 2131355.772367651 2382280.620362103 1.0 0.8335922768128016 0.931731225767458 21.285926185276796 -10.19458956584539 4.8146870518814175 1.0000155467635987 0.8826617512950745 0.655890733149036 0.040065058139959454 6.687046421754639e-06 1.1186084059787604e-06 0.038797964703811055 0.012930941911556299 6.38866968322204e-11 10.19458956584539 -0.1173537954685242 DFQYVDRDGK(ub)DQGVNVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFQYVDRDGKDQGVNVR 17 2 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 76912000.0 14209000.0 31936000.0 30767000.0 True False 21556091.817044023 26236771.28289314 24685888.96434487 1.0 1.2171395216524448 1.1451931627432654 24.36159230114888 -10.092784904539473 4.368205634734118 0.9999808553142064 1.1811663421567429 0.8942276868199353 0.02937197808510458 20430829.45653965 0.16714123303468095 4054.9026610379024 0.01005480933913443 8.076349330864621e-11 10.092784904539473 0.18118548684253644 DFSIHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFSIHR 6 0 Q09028-3;Q09028;Q09028-2;Q09028-4;E9PNS6;C9JPP3;E9PND5 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 12592000.0 3870900.0 1174200.0 7546900.0 False True 3748020.398323535 1643064.1833721062 5570140.487853031 1.0 0.43838186796076084 1.4861553289156373 21.83769737410359 -6.761128817056526 1.6083740920158154 0.674229430872563 1.4901751907868883 0.6954662219405864 0.2362569755923261 0.2810433156421449 1.4331646898410866 0.11588784817097207 0.2781701809615149 1.7332898065383803e-07 6.761128817056526 0.8159457599143253 DFSVQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFSVQIK 7 0 A0A024R4E5;Q00341;Q00341-2;H0Y394 A0A024R4E5 HDLBP Vigilin 0 18307200.0 4503800.0 4708600.0 9094800.0 False True 5904525.414861245 4006095.2339790445 8153757.339481874 1.0 0.678478785762528 1.3809335664741966 22.49338967481594 -6.782251885524832 1.527060237713374 0.818479707380352 1.3868998587645849 0.7752914812489233 0.13610362254415923 0.2470900737964665 1.138211268647798 0.0701884149755731 0.16530875153064106 1.6510039582443775e-07 6.782251885524832 0.5684201513842329 DFSVQIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFSVQIK 7 0 A0A024R4E5;Q00341;Q00341-2;H0Y394 A0A024R4E5 HDLBP Vigilin 0 11515200.0 4503800.0 3841400.0 3170000.0 False True 6168976.570618587 3671674.24618893 2421311.2881993353 1.0 0.5951836911938145 0.39249805222660156 22.556599736338832 -11.709658614834819 0.11544094187585653 2.206993210276307 6.921802875696261e-12 0.9997994541527278 0.0035764086741513663 4.824608731300196 0.0785666483817569 1.7355404008789714 0.2846761642220504 1.9513779135336366e-12 11.709658614834819 -2.2069932102693848 DFSYNYFGFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFSYNYFGFK 10 0 P23921 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 0 6806200.0 1792100.0 1967400.0 3046700.0 False True 2349460.4547210843 1673871.5888651344 2731456.7100100564 1.0 0.7124493564050423 1.1625889273945327 21.163898054340105 -6.7341505965754 1.7081255816023007 0.8277592066920146 1.1625297304540083 0.5784023587467393 0.12084491796996984 0.3285029918113107 1.8795375683663527 0.056022792924819924 0.1383667678113195 1.8443757499078608e-07 6.7341505965754 0.3347705237619937 DFSYNYFGFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFSYNYFGFK 10 0 P23921 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 0 6717400.0 1260500.0 1164300.0 4292600.0 False True 1220486.117462816 1629211.061744291 3168239.2847603583 1.0 1.3348870080809645 2.595883098897177 20.21902445446253 -6.946264219705518 0.5984538940461165 0.9857470750456303 3.0094027425491086 0.9988745505624351 0.023051031878294936 0.08502143545310553 0.042444438660283614 0.023694437744102043 0.10591786285470561 1.131711633569937e-07 6.946264219705518 2.023655667503478 up DFSYNYFGFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFSYNYFGFK 10 0 P23921 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 0 6187200.0 1792100.0 1690500.0 2704600.0 False True 2454687.7996815024 1615808.1202640652 2065829.182985464 1.0 0.6582540233726332 0.8415853059820915 21.227108115862997 -10.166313537314059 4.923637876422909 1.0000196475852443 0.7499196646767256 0.7127252390240397 0.07484468271606105 1.6143293232553725e-05 2.733500404447905e-06 0.07247374264024015 0.024156017475642565 6.818462599919812e-11 10.166313537314059 -0.25009998290851876 DFSYNYFGFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFSYNYFGFK 10 0 P23921 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 0 3899000.0 1260500.0 1433500.0 1205000.0 False True 1048161.5996181297 1425777.450972527 1456959.9287095016 1.0 1.3602649166807597 1.3900146019853303 19.999429729896807 -12.038793441050002 0.3912348091229754 2.1293623807166066e-06 1.3923645722325926 0.9997217901459269 0.0029566102567881785 5.739797378551417 0.20045975424939927 4.711782590054708 0.007798171952102276 9.14548115016101e-13 12.038793441050002 1.392362442870212 DFSYNYFGFK(ub)TLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFSYNYFGFKTLER 14 1 P23921 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 14790000.0 2517000.0 2701300.0 9571700.0 True False 2437099.2127361437 3779943.177093401 7064584.625155084 1.0 1.55100094298157 2.898767759735 21.21673355276497 -6.955928029039324 0.4894641999144586 0.9703614088071311 3.53650627095534 0.9995880807167955 0.016187789968163786 0.08118916642082359 0.02676041998283117 0.019382657225850405 0.11115975637926988 1.1068071880499266e-07 6.955928029039324 2.5661448621482092 DFSYNYFGFK(ub)TLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFSYNYFGFKTLER 14 1 P23921 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 11261800.0 2517000.0 1912500.0 6832300.0 True False 2092997.0220062146 1902196.9828984723 8260902.341014057 1.0 0.9088388387075422 3.9469250334124597 20.997138828199247 -6.899981226920652 0.9613731062485237 0.8736225450358744 4.26571689268549 0.9865573665605135 0.1636145707590725 0.11141953610765187 0.17749195386937627 0.12764529369826072 0.3320849241156315 1.2589798320514982e-07 6.899981226920652 3.392094347649616 up DFTATDLSEFAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFTATDLSEFAAK 13 0 P42765;A0A0B4J2A4 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 16670900.0 2348600.0 7729200.0 6593100.0 False True 3079037.3438747553 6576033.48818562 5910909.257480971 1.0 2.135743335905805 1.919726394108134 21.554047934432205 -10.168636380274089 4.433575523506403 0.99979037690702 2.027734865037118 0.9679285916044222 0.08818854731112968 30902007.58052502 27.084563679149376 66822.63154735397 0.030189285405860057 6.782091109559193e-11 10.168636380274089 1.027944488130098 DFTATDLSEFAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFTATDLSEFAAK 13 0 P42765;A0A0B4J2A4 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 15789400.0 4839900.0 1783900.0 9165600.0 False True 4686260.023727321 2496220.5729156076 6764854.397893936 1.0 0.5326679612904158 1.4435507982148543 22.160005575709235 -6.767272194925764 1.5851598233095066 0.7310151844192141 1.4481227093274154 0.7199234457175425 0.19682243618136913 0.2708623564256913 1.3428114758325747 0.09790057874573907 0.23360704609816818 1.7089438954006493e-07 6.767272194925764 0.7171075249082013 DFTATDLSEFAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFTATDLSEFAAK 13 0 P42765;A0A0B4J2A4 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 14080900.0 2348600.0 5759500.0 5972800.0 False True 3216940.888528535 5505026.245880445 4562147.653677278 1.0 1.7112612375039649 1.4181633457878227 21.617257995955097 -10.104017595439636 4.595234578287873 0.999966122073062 1.5647122915612663 0.8319207407998843 0.11965671339984321 83324545.03929675 3.380331847605597 38007.308208424525 0.04096167565240504 7.870139031832272e-11 10.104017595439636 0.5647461694882043 DFTATDLSEFAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFTATDLSEFAAK 13 0 P42765;A0A0B4J2A4 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 9123400.0 4839900.0 1804500.0 2479000.0 False True 4024591.2939244662 1794778.800334793 2997347.43839905 1.0 0.445953059393682 0.7447582175422021 21.94041085114351 -10.640792058057727 8.207119237724518 1.0004560485534197 0.595355638467942 0.7097387904794343 0.12198669499591754 0.0010189976982752568 4.459921775159125e-05 0.1182374360859746 0.039371036514839364 2.2866934192948998e-11 10.640792058057727 -0.4051004100854777 DFTILQK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFTILQKK 8 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9;Q5T4C6 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 4272200.0 2359300.0 0.0 1912900.0 True False 3093065.1474936972 0.0 1714971.457832484 1.0 0.0 0.5544569467675523 21.56060578974659 -9.909340080954417 5.892823084031875 1.000000270355425 0.27722847338331086 0.6937882792912133 0.22635610065532027 8.038321050209462e-07 1.4852845666440534e-07 0.21916843368043598 0.07305611734563369 1.2321396095442171e-10 9.909340080954417 -0.7227717969721141 DFTILQK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFTILQKK 8 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9;Q5T4C6 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 23299600.0 6004200.0 8562800.0 8732600.0 True False 5813599.957532919 11981970.694412097 6445270.087615502 1.0 2.061024284769813 1.1086538693231036 22.471000370220434 -6.620291519912068 2.115617133244199 1.703885738717165 1.1122987629605972 0.08370592379396757 0.4562459753464508 0.5847062172342552 4.973349932787424 0.1771727126809512 0.505890721979892 2.397223244159775e-07 6.620291519912068 -0.5915869757565679 DFTILQK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFTILQKK 8 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9;Q5T4C6 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 17550600.0 4964100.0 5294500.0 7292000.0 True False 7530902.62432177 4349655.108882694 5850733.003802868 1.0 0.5775742066873985 0.7768966478078426 22.84439136032904 -10.04839718552459 4.915616175798699 1.000006779093578 0.6772354272443701 0.7775906778323494 0.08137304584974321 6.045644350274834e-06 1.1703686697351325e-06 0.07879076780043787 0.026263037615582165 8.945462809290905e-11 10.04839718552459 -0.3227713518492079 DFTILQK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFTILQKK 8 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9;Q5T4C6 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 16162800.0 6004200.0 6894800.0 3263800.0 True False 4992758.331159998 6857656.343889351 3946245.489893838 1.0 1.3735205850222016 0.7903938520847619 22.25140564565471 -6.7336922591968085 1.709660559876554 1.2238523401411758 0.7904932343704851 0.5763397447996597 0.15697896082693366 0.32936141534623725 1.88761478219911 0.07271248447968207 0.17968916577030253 1.8463232592851688e-07 6.7336922591968085 -0.4333591057706907 DFTILQK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFTILQKK 8 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9;Q5T4C6 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 12183000.0 4964100.0 5270400.0 1948500.0 True False 6426125.307040012 4977097.606946053 1593892.9932983378 1.0 0.7745098903523548 0.24803328866808438 22.61551768242149 -6.979443017946165 0.4839572880058952 1.0121312755012615 1.409595670536557e-10 0.9996390659595743 0.005985965857679786 0.0775004255413448 0.025502984171335303 0.007349043045520455 0.041526224883797064 1.048472350448944e-07 6.979443017946165 -1.012131275360302 down DFTNYGLEHWGSDTQGVEK(ub)TR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFTNYGLEHWGSDTQGVEKTR 21 1 Q96G46-3;Q96G46;K7EM42 Q96G46-3 DUS3L tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like 1 29133500.0 5896300.0 6232200.0 17005000.0 True False 7632876.583449169 5885372.591455911 13910264.486034503 1.0 0.7710556468602575 1.8224144375918478 22.86379543379843 -6.849658014111914 1.2366297878823265 0.8778542009248975 1.8641920792847002 0.9398184955328578 0.11074549577297148 0.15783612126796978 0.4646349113755794 0.07007951636048694 0.1621439768456001 1.4136502876416567e-07 6.849658014111914 0.9863378783598027 DFTPVCTTELGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFTPVCTTELGR 12 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 30213800.0 1239800.0 18097000.0 10877000.0 False True 1625389.8062402797 15396998.141553495 9751552.379551439 1.0 9.472803436099175 5.999516141981929 20.632354320751105 -9.539013958044576 13.457043805159078 1.0000000000059674 7.736159788985886 0.8337525180363786 1.4179636001132223 0.0 0.0 1.3729373521917057 0.45764578406390183 2.8905869786055776e-10 9.539013958044576 6.7361597889799185 DFTPVCTTELGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFTPVCTTELGR 12 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 15252300.0 6899900.0 2012400.0 6340000.0 False True 6680866.451314315 2815961.814527361 4679363.804076941 1.0 0.4214964982533638 0.7004127141557182 22.671603789381592 -10.470886851256108 6.229968774537448 1.0002218967954108 0.5609546062045541 0.7676456792271491 0.11386706832478598 0.00035111711132009184 2.9820283098700673e-05 0.11030591299447717 0.03675043827527983 3.381529252711947e-11 10.470886851256108 -0.4392672905908568 DFTPVCTTELGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFTPVCTTELGR 12 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 50826800.0 1239800.0 20981000.0 28606000.0 False True 1698187.5643352112 20053990.04511114 21849851.959063154 1.0 11.80905482190459 12.866571642583372 20.695564382273997 -9.487279936942267 0.6973309270592992 2.294453011323734e-21 12.698349010918712 0.9990852536886005 0.16217565005736956 0.8240239255010271 0.33367172683886787 2.569246618015322 0.164238748192333 3.2562674130263157e-10 9.487279936942267 12.698349010918712 DFTVSALHGDMDQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFTVSALHGDMDQK 14 0 Q14240-2;Q14240;E7EQG2 Q14240-2 EIF4A2 Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 9381900.0 1877900.0 3461300.0 4042700.0 False True 2461945.085609472 2944887.532041725 3624400.1843166845 1.0 1.1961629645011749 1.4721693857031903 21.23136715177918 -6.966298756478058 0.33501451339125105 0.9682803345701562 1.7091556696905288 0.9999374674761996 0.0015315530076667112 0.07752295843657653 0.013320877536141626 0.003958554615182138 0.023979062538867994 1.0806902754966508e-07 6.966298756478058 0.7408753351203726 DFTVSALHGDMDQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFTVSALHGDMDQK 14 0 Q14240-2;Q14240;E7EQG2 Q14240-2 EIF4A2 Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 8063800.0 1877900.0 3099200.0 3086700.0 False True 2572210.378339325 2962267.0963161206 2357685.032581981 1.0 1.1516426188392197 0.9165988336086854 21.294577213302073 -6.732509745231765 1.7138977935002528 1.0910033005932196 0.9166694797059902 0.5708737143568448 0.063735734332047 0.33158754453743045 1.9092730616275435 0.02945487411896089 0.0728885805845483 1.8513573507143036e-07 6.732509745231765 -0.17433382088722937 DFTVSALHGDMDQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFTVSALHGDMDQK 14 0 Q14240-2;Q14240;E7EQG2 Q14240-2 EIF4A2 Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 3600200.0 1569600.0 1072700.0 957900.0 False True 1305191.9450699068 1066921.1521857216 1158192.4611708159 1.0 0.8174438680960269 0.8873732829455843 20.315830558370145 -10.915514110153692 10.31203720782667 1.019853609921706 0.8524085755208055 0.8558949260537495 0.028548564065470083 0.012104933834153894 9.917482544551136e-05 0.02567805540029262 0.009214009431975088 1.2147471529021325e-11 10.915514110153692 -0.16744503440090042 DFTVSALHGDMDQK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFTVSALHGDMDQKER 16 1 Q14240-2;Q14240;E7EQG2 Q14240-2 EIF4A2 Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 13310200.0 4470000.0 8840200.0 0.0 True False 5860213.287541575 7521276.618829713 0.0 1.0 1.283447589666992 0.0 22.48252174306364 -6.887825923139457 1.3234932727026374 1.1477018584342564 2.614695509954448e-20 0.9373282051973292 0.13781724998838774 0.14299429333714664 0.5032760943786567 0.08469563449370265 0.17107230681640884 1.2947146937851485e-07 6.887825923139457 -1.1477018584342564 down DFTVSALHGDMDQK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFTVSALHGDMDQKER 16 1 Q14240-2;Q14240;E7EQG2 Q14240-2 EIF4A2 Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 11777100.0 4311600.0 7465500.0 0.0 True False 3585286.436266189 7425281.869714265 0.0 1.0 2.071042858558087 0.0 21.773656952874227 -6.771215335595945 1.602880470488785 1.6171097015929805 4.508166644528154e-10 0.7153859074232317 0.45115608190795703 0.26906212647319605 1.3698111360620562 0.2230511478760205 0.5233356832734588 1.6934979076595768e-07 6.771215335595945 -1.6171097011421638 DFTVSAMHGDMDQK ddPTM_RPMI8226_Bortezomib_1h_R1 3 DFTVSAMHGDMDQK 14 0 P60842;J3KT12;P60842-2;J3KSZ0;J3QL52 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 131546800.0 45087000.0 41239500.0 45220300.0 False True 59109493.62312914 35086727.350311995 40541337.139747135 1.0 0.5935886978497613 0.685868456228554 25.816886525630494 -10.464722982119714 5.658649263351553 1.0003370426897227 0.6397285770391632 0.9531020411852552 0.037673053602562116 0.00016033487139737972 1.5166733283766072e-05 0.03651019333511975 0.012158925766958291 3.429864932056979e-11 10.464722982119714 -0.3606084656505595 DFTVSAMHGDMDQK ddPTM_RPMI8226_Bortezomib_2h_R1 3 DFTVSAMHGDMDQK 14 0 P60842;J3KT12;P60842-2;J3KSZ0;J3QL52 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 72491140.0 15810200.0 6025440.0 50655500.0 False True 15308313.855065946 8431429.614254508 37387304.917573966 1.0 0.5507745460460568 2.442287587747717 23.86781204914594 -6.844074688122271 1.2634938516447585 0.761012837933754 2.509625900864917 0.9312090689766332 0.211634479323811 0.1640970470108727 0.5071280915953645 0.13125057722174224 0.3027619511784284 1.431941618853187e-07 6.844074688122271 1.7486130629311631 up DFTVSAMHGDMDQK ddPTM_RPMI8226_Bortezomib_8h_R1 2 DFTVSAMHGDMDQK 14 0 P60842;J3KT12;P60842-2;J3KSZ0;J3QL52 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 143727200.0 17484200.0 109505000.0 16738000.0 False True 26524809.666236974 89962977.18352999 13429726.96347399 1.0 3.391654014318621 0.5063081368899881 24.660839063058976 -6.686601045390858 1.8782032738230916 2.5041448860874898 0.5165926999287168 0.35467141790321666 1.0122074451267378 0.42402984644886377 2.8973360037770353 0.43153481396631815 1.1287054495753042 2.057780060186137e-07 6.686601045390858 -1.9875521861587728 DFTVSAMHGDMDQK ddPTM_RPMI8226_Carfilzomib_1h_R1 3 DFTVSAMHGDMDQK 14 0 P60842;J3KT12;P60842-2;J3KSZ0;J3QL52 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 118384400.0 45087000.0 28458300.0 44839100.0 False True 61756882.33036109 27200918.20698662 34249028.070251964 1.0 0.44045160928750493 0.5545783203083482 25.880096587153385 -10.357316743879133 7.987975764279827 1.000003693047199 0.4975149647981641 0.9627519108536449 0.04659203467052258 3.064348437496413e-06 2.465782053886639e-07 0.04511287478709832 0.015037514528737715 4.392211615406666e-11 10.357316743879133 -0.5024887282490349 DFTVSAMHGDMDQK ddPTM_RPMI8226_Carfilzomib_2h_R1 3 DFTVSAMHGDMDQK 14 0 P60842;J3KT12;P60842-2;J3KSZ0;J3QL52 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 45880000.0 15810200.0 17472200.0 12597600.0 False True 13146881.810616868 17378073.790639833 15231699.915278696 1.0 1.3218399648657397 1.1585789037046197 23.648217324580216 -10.403011931714525 4.245658625155997 0.9992985729431958 1.2402094342870187 0.7426911935902842 0.06665104912451521 0.00044379452842958797 6.240248010882291e-05 0.0647199734928638 0.021511533604685426 3.953557579986377e-11 10.403011931714525 0.2409108613438229 DFTVSAMHGDMDQK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DFTVSAMHGDMDQK 14 0 P60842;J3KT12;P60842-2;J3KSZ0;J3QL52 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 53550900.0 17484200.0 23844100.0 12222600.0 False True 22633641.565107312 22517154.874351546 9998212.214466657 1.0 0.9948533827214378 0.4417412101232616 24.431965385151425 -6.908936653221017 0.9029444330928691 1.0177067167627747 0.3718627316116673 0.9905140893115435 0.025513865827480137 0.10512543834491647 0.14261208199123582 0.020779331717308377 0.0569465238651246 1.2332847086814322e-07 6.908936653221017 -0.6458439851511074 down DFTVSAMHGDMDQK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 4 DFTVSAMHGDMDQKER 16 1 P60842;J3KT12;P60842-2;J3KSZ0;J3QL52 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 214483200.0 70953700.0 84758300.0 58771200.0 True False 93020987.81660816 72112692.02526565 52690119.99715848 1.0 0.7752303401404054 0.5664326001465132 26.471052924548744 -6.972011637903341 0.20451746256621903 1.1172623667403285 0.21860723738129728 0.9999941111357928 0.0004295915722221936 0.0756552632116329 0.006640735010686221 0.0065335345904627045 0.021919564137944453 1.066567539756707e-07 6.972011637903341 -0.8986551293590312 DFTVSAMHGDMDQK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 4 DFTVSAMHGDMDQKER 16 1 P60842;J3KT12;P60842-2;J3KSZ0;J3QL52 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 312986900.0 76108600.0 85446700.0 151431600.0 True False 73692574.15274145 119566012.90865383 111767121.10937794 1.0 1.6224974399839964 1.5166673493820417 26.13501591348071 -10.05915424213003 4.350789428477005 0.9999547844932466 1.5695823947026384 0.9747614249035685 0.04320495382547986 5612945.3561844295 3244324.86713017 2260.0724821592125 0.014790204863967331 8.726613827422279e-11 10.05915424213003 0.5696276102093918 DFTVSAMHGDMDQK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 4 DFTVSAMHGDMDQKER 16 1 P60842;J3KT12;P60842-2;J3KSZ0;J3QL52 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 2156025600.0 191340200.0 253713200.0 1710972200.0 True False 290277072.24235094 208436097.18972057 1372797794.724243 1.0 0.7180591135895785 4.729267055505164 28.11285538318693 -6.8900365566598865 1.0222044944887205 0.7846607942164896 5.074466415555873 0.9809203196079049 0.2525105197213526 0.11911196440108572 0.22169318775411698 0.18821741128407976 0.46927394490374613 1.2881411180826246e-07 6.8900365566598865 4.289805621339384 up DFTVSAMHGDMDQK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 3 DFTVSAMHGDMDQKER 16 1 P60842;J3KT12;P60842-2;J3KSZ0;J3QL52 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 235906100.0 69523700.0 78505600.0 87876800.0 True False 95228490.6973478 75036963.00869724 67122109.71950635 1.0 0.7879675762916096 0.7048532348667768 26.504889931426003 -13.999999999999998 0.12944702870640898 2.007566159047832 0.5876357581992298 0.9996481251755484 0.0023310067602671835 11.937596261494184 0.11183027194873087 3.061819840339955 0.10422402518172022 1.0000000000000041e-14 13.999999999999998 -1.4199304008486022 DFTVSAMHGDMDQK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 4 DFTVSAMHGDMDQKER 16 1 P60842;J3KT12;P60842-2;J3KSZ0;J3QL52 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 302521400.0 76108600.0 132959000.0 93453800.0 True False 63287673.08266281 132242723.47670496 112994557.49844995 1.0 2.089549465722605 1.7854117870768103 25.915421188914987 -10.073637248315995 4.379055823561909 0.9999207618768898 1.9374806264897273 0.9268387213937295 0.12416368770326973 12525902.393309766 4802462.950544431 9550.715111994923 0.042504533483748164 8.44039461403705e-11 10.073637248315995 0.9375598646128375 DFTVSAMHGDMDQK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 4 DFTVSAMHGDMDQKER 16 1 P60842;J3KT12;P60842-2;J3KSZ0;J3QL52 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 1834904400.0 191340200.0 240798200.0 1402766000.0 True False 247693660.77921456 227397568.49137038 1147476981.5946293 1.0 0.9180597023597814 4.632645736611927 27.88398170527938 -6.9018565008577175 0.9494516295365889 0.8533293282106877 5.037601732747275 0.9874676608353454 0.1939030176039369 0.1100517813801119 0.16981082647762574 0.15261867557886355 0.4009194847999997 1.253555304992049e-07 6.9018565008577175 4.184272404536587 up DFVAEPMGEKPVGSLAGIGEVLGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 DFVAEPMGEKPVGSLAGIGEVLGK 24 1 O75531 O75531 BANF1 Barrier-to-autointegration factor;Barrier-to-autointegration factor, N-terminally processed 0 70917600.0 24039000.0 12501100.0 34377500.0 False True 23275895.10328334 17492854.42237528 25373001.447106466 1.0 0.7515437900348549 1.0900977743076057 24.472333313681414 -6.710025352478264 1.7951361080510322 0.847257252326487 1.0893018041995601 0.46519013732676284 0.10469782761484274 0.3750364619087989 2.3559039115191225 0.04641289940139778 0.11790598915404281 1.9497307784868707e-07 6.710025352478264 0.24204455187307317 DFVASIDATYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFVASIDATYAK 12 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 9817000.0 2157700.0 1849800.0 5809500.0 False True 2089204.9945652653 2588434.7865795675 4287817.668735803 1.0 1.2389568248749976 2.052368092116321 20.994522627135076 -6.948581279265817 0.5742065032593238 0.990050943049107 2.3411082871600404 0.9990852048474947 0.01362438184846281 0.08406045541023269 0.03835877799685491 0.014365897160379837 0.06784477680502339 1.1256897736076153e-07 6.948581279265817 1.3510573441109335 up DFVASIDATYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFVASIDATYAK 12 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 27573000.0 4369400.0 14884000.0 8319600.0 False True 6628699.245928083 12227833.910777206 6675227.413389779 1.0 1.8446807521533872 1.0070192002586749 22.660294366425337 -10.209855609777806 4.772477094022957 0.9999278376572932 1.4258499762074677 0.25628420102247385 0.34197389655326327 0.0002626168219263115 4.3479040620195584e-05 0.3311706971407571 0.11037160051500244 6.168000357605016e-11 10.209855609777806 0.42592213855017447 DFVDLSTGEDAHK(ub)LIDFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFVDLSTGEDAHKLIDFLK 19 1 O75794;X6RA30 O75794 CDC123 Cell division cycle protein 123 homolog 1 7293200.0 2365400.0 2002600.0 2925200.0 True False 2290311.671754497 2802248.6234210376 2159002.3658810495 1.0 1.2235228322765217 0.9426674947812418 21.12711250681609 -6.694645002468743 1.8496483992390895 1.1395158138754997 0.9435722872237218 0.39240232123857566 0.09444656986295456 0.40674199578879966 2.701356591420706 0.04079272220397608 0.10561958517926241 2.0200168750971442e-07 6.694645002468743 -0.19594352665177794 DFVDLSTGEDAHK(ub)LIDFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFVDLSTGEDAHKLIDFLK 19 1 O75794;X6RA30 O75794 CDC123 Cell division cycle protein 123 homolog 1 7816300.0 2365400.0 2876500.0 2574400.0 True False 1966934.904987483 2861003.7235594536 3112695.13731929 1.0 1.454549266630489 1.5825104986578589 20.907517782250366 -11.832656733240217 0.21520450393386983 1.425628936846924e-12 1.6628806575029762 0.9993679036778291 0.006284303745782453 4.801885989756998 0.12972506403541315 2.2409848266967045 0.07269608547406066 1.4700877772957295e-12 11.832656733240217 1.6628806575015507 DFVNYLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFVNYLVR 8 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 11370800.0 3896900.0 0.0 7473900.0 False True 5108873.637633283 0.0 6700572.522711175 1.0 0.0 1.3115557357600365 22.284573822029035 -6.702907034155203 1.8203847029564917 0.38080377183302005 1.307887693908811 0.4313744640545729 0.4218948907095005 0.38953516446760994 2.5115194448470946 0.18474889506300607 0.47344864469826325 1.9819512403867916e-07 6.702907034155203 0.927083922075791 DFVNYLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFVNYLVR 8 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 7615000.0 3201500.0 1197500.0 3216000.0 False True 3099870.1349124997 1675667.9948800036 2373633.1220680503 1.0 0.5405607080140804 0.7657201814149711 21.563776346229435 -10.146056398126264 5.060926792067036 1.0000165351187391 0.6531404447139648 0.7598585442381471 0.09192097009960741 1.715036894727131e-05 2.893741637515853e-06 0.08900633529576334 0.02966736552997125 7.144035465460929e-11 10.146056398126264 -0.3468760904047743 DFVNYLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFVNYLVR 8 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 16232000.0 3896900.0 5897000.0 6438100.0 False True 5337689.23976277 5636451.04122875 4917553.376831581 1.0 1.055972123524984 0.9212888116825134 22.347783883551926 -6.793819662562667 1.480890624281307 1.0311280047890155 0.91969874167967 0.813511234262888 0.023857118783567274 0.22970032617418196 0.9950008023590027 0.01267743376416442 0.029602450906660582 1.607608661545102e-07 6.793819662562667 -0.11142926310934542 DFVNYLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFVNYLVR 8 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 5690900.0 3201500.0 1076000.0 1413400.0 False True 2662189.1004977725 1070203.374430723 1708935.4051767718 1.0 0.40200126062818675 0.6419286311619402 21.34418162166371 -10.282348261099926 5.65953958280544 1.0000414840664682 0.5219649458950689 0.8410922753023096 0.0979499388559183 5.1275080482463724e-05 6.501970136366026e-06 0.09484782333108764 0.031613206829247106 5.219774469855006e-11 10.282348261099926 -0.4780765381713993 DFWSSSQHISIEGQK(ub)EEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFWSSSQHISIEGQKEEER 19 1 H9KVA9;A0A0D9SF50;P46736;P46736-4;X6RJS7 H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 9627400.0 2315200.0 2904800.0 4407400.0 True False 2241705.2432764093 4064701.7883318863 3252969.7208341793 1.0 1.8132186649084336 1.4511139368527042 21.096165163248354 -10.044038033923844 5.0653260699258436 0.999992607136581 1.6321663008765923 0.8025201025248813 0.14782863621231135 1.5175521010619569e-05 2.8637965309366655e-06 0.1431365159806545 0.04771148717644188 9.035703388684853e-11 10.044038033923844 0.6321736937400113 DFWSSSQHISIEGQK(ub)EEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFWSSSQHISIEGQKEEER 19 1 H9KVA9;A0A0D9SF50;P46736;P46736-4;X6RJS7 H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 8795600.0 2315200.0 3996000.0 2484400.0 True False 1925191.380750413 3974472.7548561 3003876.553432276 1.0 2.0644559260944257 1.5603002296121886 20.87657043868263 -10.180427881543057 5.39392990093014 0.999969165296054 1.8123780778534702 0.7758847352084784 0.2058207012170664 7.632307628253868e-05 1.159691965881623e-05 0.1992925739142412 0.06642834567645273 6.600428311394014e-11 10.180427881543057 0.8124089125574162 DFWSSSQHISIEGQK(ub)EEERYER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFWSSSQHISIEGQKEEERYER 22 2 H9KVA9;A0A0D9SF50;P46736;P46736-4;X6RJS7 H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 22582800.0 3539500.0 10421000.0 8622300.0 True False 5369680.272111141 8561291.13035537 6918098.625711663 1.0 1.5943763309001293 1.2883632311671596 22.356404757428315 -10.121826934719072 4.721233180552276 0.9999684688310844 1.4413697810386865 0.7350100571154139 0.1249293248428354 4.1466308462632335e-05 7.71270191529528e-06 0.1209709238612603 0.04032076621165125 7.55393190019991e-11 10.121826934719072 0.44140131220760215 DFWSSSQHISIEGQK(ub)EEERYER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFWSSSQHISIEGQKEEERYER 22 2 H9KVA9;A0A0D9SF50;P46736;P46736-4;X6RJS7 H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 20435200.0 3539500.0 7797400.0 9098300.0 True False 4581952.523975773 7363467.835534535 7442502.756441503 1.0 1.6070589551079053 1.624308134468321 22.127531079520764 -11.354456187903331 0.5810034452490709 3.5286935184822635e-15 1.6224163918877836 0.9999322590052414 0.0023894811047512924 3.952178914479861 0.2874762769849543 5.057780778494814 0.0030787600735074834 4.421237165442842e-12 11.354456187903331 1.62241639188778 DFYFGK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFYFGKLR 8 1 Q15691;Q15555-4;Q15555-5;Q15555-3;Q15555 Q15691;Q15555-4 MAPRE1;MAPRE2 Microtubule-associated protein RP/EB family member 1;Microtubule-associated protein RP/EB family member 2 1 10872100.0 3135000.0 3786900.0 3950200.0 True False 4110015.3593831905 3221909.281220586 3541471.196994033 1.0 0.7839166035876112 0.8616686039649055 21.970712354682362 -10.783583216177414 9.795034085102964 1.0013448444841513 0.8227926047482329 0.8738321377425503 0.03174212123417606 0.0009384287817453207 2.073412020120725e-05 0.03093904087582279 0.010244725576105064 1.6459505516909646e-11 10.783583216177414 -0.17855223973591838 DFYFGK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFYFGKLR 8 1 Q15691;Q15555-4;Q15555-5;Q15555-3;Q15555 Q15691;Q15555-4 MAPRE1;MAPRE2 Microtubule-associated protein RP/EB family member 1;Microtubule-associated protein RP/EB family member 2 1 55349000.0 14211000.0 27867000.0 13271000.0 True False 21559125.963263564 22893916.124135233 10647981.033114059 1.0 1.0619129997730954 0.4938966937369383 24.36179535463843 -6.879894893092038 1.0804408489061077 1.0383142814826214 0.45373167496588973 0.9735981393999115 0.04134160407281525 0.127720677127282 0.2728795394273863 0.029479275061881954 0.07126614574180784 1.318575818497647e-07 6.879894893092038 -0.5845826065167317 down DFYFGK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFYFGKLR 8 1 Q15691;Q15555-4;Q15555-5;Q15555-3;Q15555 Q15691;Q15555-4 MAPRE1;MAPRE2 Microtubule-associated protein RP/EB family member 1;Microtubule-associated protein RP/EB family member 2 1 12855700.0 3135000.0 3383400.0 6337300.0 True False 4294094.220189458 3233910.2005923972 4840560.26079042 1.0 0.7531064841073085 1.1272599092101085 22.033922416205254 -6.7287428494629475 1.727691646666602 0.851211208153662 1.1269906654132116 0.5534328654499217 0.10379927467023697 0.33862477187676304 1.9795815580998286 0.04762076785232982 0.11834177834181854 1.8674851220039106e-07 6.7287428494629475 0.27577945725954955 DFYFGK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFYFGKLR 8 1 Q15691;Q15555-4;Q15555-5;Q15555-3;Q15555 Q15691;Q15555-4 MAPRE1;MAPRE2 Microtubule-associated protein RP/EB family member 1;Microtubule-associated protein RP/EB family member 2 1 15354200.0 4554100.0 7882100.0 2918000.0 True False 3786935.9308377057 7839637.562825655 3528140.3086923854 1.0 2.0701796138102218 0.9316609451884568 21.852599582560075 -6.660128312297664 1.971928634092639 1.6888082020948656 0.9363719375019598 0.2361373718159877 0.45564911189901214 0.4842890918566198 3.6200763009503705 0.1866507090292526 0.5052728700895782 2.1871153452893003e-07 6.660128312297664 -0.7524362645929058 DFYFGK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFYFGKLR 8 1 Q15691;Q15555-4;Q15555-5;Q15555-3;Q15555 Q15691;Q15555-4 MAPRE1;MAPRE2 Microtubule-associated protein RP/EB family member 1;Microtubule-associated protein RP/EB family member 2 1 49971400.0 14211000.0 28828000.0 6932400.0 True False 18396419.64068927 27223696.458151333 5670774.332430797 1.0 1.4798366741938123 0.30825423876981783 24.13292167673088 -6.795494923622703 1.474215042156185 1.2662766052153938 0.2938200791594081 0.8186708223718561 0.20477940660515473 0.22725124906757285 0.9754511211140681 0.10930285101429345 0.25492957175993164 1.6014193668907413e-07 6.795494923622703 -0.9724565260559856 down DFYFSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFYFSVK 7 0 Q9NY12-2;Q9NY12 Q9NY12-2 GAR1 H/ACA ribonucleoprotein complex subunit 1 0 16282800.0 4333300.0 5818000.0 6131500.0 False True 5680998.263736892 4949977.0783863785 5497071.197501115 1.0 0.8713217023816416 0.967624164328684 22.437713031378138 -10.070117672361345 4.802734511394371 1.0000027539886276 0.919472933507399 0.4824774292601287 0.03931531546109665 1.159388902025419e-06 2.2447940821335696e-07 0.03806819204726173 0.012688963502109447 8.509074530588923e-11 10.070117672361345 -0.08052982048122859 DFYFSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DFYFSVK 7 0 Q9NY12-2;Q9NY12 Q9NY12-2 GAR1 H/ACA ribonucleoprotein complex subunit 1 0 19236000.0 5582900.0 2480000.0 11173100.0 False True 5405673.895424952 3470276.9330291473 8246529.924184866 1.0 0.6419693455733961 1.5255322617896447 22.366043051295968 -6.796710655548343 1.469380291726176 0.8016277339626636 1.536751225432619 0.8223504450714388 0.1529430659290919 0.22548672461758526 0.9614661211635102 0.0818996995797925 0.19085649068107824 1.5969427403776016e-07 6.796710655548343 0.7351234914699554 DFYFSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFYFSVK 7 0 Q9NY12-2;Q9NY12 Q9NY12-2 GAR1 H/ACA ribonucleoprotein complex subunit 1 0 22965600.0 8495200.0 2568400.0 11902000.0 False True 12887839.482310677 2110048.952999208 9549564.48316808 1.0 0.16372402495355218 0.7409748155441743 23.61950709475316 -10.190536447092809 7.044558441805348 1.0000010869017013 0.45234942029356473 0.545474823940884 0.23566164842753493 4.023060884603999e-06 4.623896608858666e-07 0.2281788620698879 0.07605946997496918 6.448571995478388e-11 10.190536447092809 -0.5476516666081366 DFYFSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFYFSVK 7 0 Q9NY12-2;Q9NY12 Q9NY12-2 GAR1 H/ACA ribonucleoprotein complex subunit 1 0 14479300.0 4333300.0 4906900.0 5239100.0 False True 5935438.113029331 4690096.933051609 4001732.482651455 1.0 0.7901854663021457 0.6742101267751319 22.50092309290103 -13.999999994889857 0.07090981197033597 2.205454451077413 0.26108256404784985 0.9999212944402619 0.0011961434100772376 12.350951293882867 0.07217464151571391 2.4494084857645984 0.37998669782206096 1.0000000117665401e-14 13.999999994889857 -1.944371887029563 DFYFSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFYFSVK 7 0 Q9NY12-2;Q9NY12 Q9NY12-2 GAR1 H/ACA ribonucleoprotein complex subunit 1 0 10172100.0 5582900.0 2235800.0 2353400.0 False True 4642428.714405436 2223755.301628445 2845485.059107838 1.0 0.4790068816195587 0.6129302643416603 22.146448326730244 -10.238921053951406 8.24733980723631 1.0000002399988879 0.5459685729806616 0.9387438941038513 0.05467399204943564 2.4122141612674714e-07 2.2381487965465488e-08 0.05293789277768346 0.017645955056511748 5.7687131752677936e-11 10.238921053951406 -0.4540316670182263 DFYQFTFNFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DFYQFTFNFAK 11 0 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 0 27081800.0 10214000.0 6549800.0 10318000.0 False True 15495384.743422294 5380937.016179025 8278642.777459947 1.0 0.3472606266496999 0.53426506760177 23.8853352410483 -10.372581193989689 5.045557895963149 1.0003818722545612 0.44076284712570235 0.9226253894762122 0.07634424332807724 0.0003281655756595631 4.080758762739815e-05 0.07396899494413492 0.02463999858233582 4.240516974602173e-11 10.372581193989689 -0.5596190251288589 DFYQFTFNFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DFYQFTFNFAK 11 0 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 0 17937000.0 10214000.0 3115700.0 4607300.0 False True 13222224.348040275 2942308.556079582 3768818.6748901363 1.0 0.22252750207764208 0.28503666067719763 23.65646156314075 -10.808307183583887 10.7865384493914 1.0063850417100202 0.25378208137742025 0.994764747515977 0.025519257136603034 0.003855028306489809 6.850943578662737e-05 0.02430889368807686 0.008236304824804029 1.5548654608179517e-11 10.808307183583887 -0.7526029603325999 DFYVAFQDLPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DFYVAFQDLPTR 12 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 22488700.0 5618400.0 8476300.0 8394000.0 False True 7365776.808663005 7211669.0803586235 7525469.40093359 1.0 0.9790778715799353 1.0216803463394069 22.812406251938768 -6.773210379572348 1.5625768860056501 0.9880486286663545 1.021947185227253 0.7425328261108577 0.00882557464793178 0.26127585805783965 1.2594887972435176 0.004451177008517427 0.010562969289280648 1.685736228506949e-07 6.773210379572348 0.033898556560898574 DFYVAFQDLPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DFYVAFQDLPTR 12 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 24509200.0 5618400.0 7591800.0 11299000.0 False True 7695674.311551021 7256369.173274621 8630408.91020955 1.0 0.9429153157356187 1.1214623385575861 22.87561631346166 -6.82068240854027 1.3688564331659667 0.9692523073635635 1.1254194711848802 0.8859553305158231 0.025143542480158893 0.19259881796376171 0.708924063413372 0.01443334319129218 0.03326165789472539 1.5111848515073166e-07 6.82068240854027 0.15616716382131668 DFYVAFQDLPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DFYVAFQDLPTR 12 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 26910700.0 10688000.0 7069100.0 9153600.0 False True 8887545.558681926 7031017.355193516 11067575.438535534 1.0 0.7911090085299385 1.24529043091363 23.08335361951232 -6.781625257832214 1.5293016352181414 0.8819710768692008 1.2490886331890871 0.7731774185225948 0.0884018374697887 0.24805639082395767 1.1459560821874468 0.045521713256489515 0.10727779971498133 1.6533878511351105e-07 6.781625257832214 0.3671175563198863 DGADFAK(ub)WR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGADFAKWR 9 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78;P09972;A8MVZ9;J3KSV6;J3QKP5;K7EKH5;C9J8F3 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 1 19858500.0 4711700.0 4333800.0 10813000.0 True False 6177084.328167703 3687213.9330200925 9694174.485620078 1.0 0.5969181796994868 1.5693770670111027 22.558494595498566 -6.794131983884644 1.479742829473771 0.7759221797850171 1.5809357934213237 0.8144484218741874 0.1718439934818443 0.2292449193389736 0.9914900526777587 0.09138756214378231 0.21333871619626696 1.606452971136173e-07 6.794131983884644 0.8050136136363066 DGADFAK(ub)WR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGADFAKWR 9 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78;P09972;A8MVZ9;J3KSV6;J3QKP5;K7EKH5;C9J8F3 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 1 34690100.0 10375000.0 8234100.0 16081000.0 True False 10045651.303987868 11522019.070264239 11868903.680340894 1.0 1.1469658583202356 1.181496681616775 23.260067767613002 -13.999999999999787 0.20346910403238463 0.17203000176277836 1.2031713112627982 0.9994874017491245 0.001781635456447205 12.601750031290466 0.1430135675316432 4.158585285374942 0.021432185216194635 1.0000000000004908e-14 13.999999999999787 1.03114130950002 DGADFAK(ub)WR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGADFAKWR 9 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78;P09972;A8MVZ9;J3KSV6;J3QKP5;K7EKH5;C9J8F3 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 1 90481000.0 16973000.0 15098000.0 58410000.0 True False 25749281.89251094 12403643.938787594 46865237.89798758 1.0 0.4817083439672598 1.8200599959883976 24.618028862543916 -6.801717287805132 1.4490740673840272 0.7146588241935973 1.8392887237873643 0.8370895990020956 0.22239146716689406 0.21831507660261548 0.9048784585093801 0.12073036082411932 0.2804626673922599 1.578638579886561e-07 6.801717287805132 1.1246298995937671 DGADFAK(ub)WR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGADFAKWR 9 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78;P09972;A8MVZ9;J3KSV6;J3QKP5;K7EKH5;C9J8F3 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 1 33441000.0 10375000.0 10590000.0 12476000.0 True False 8627272.190430852 10532949.568049578 15084673.91749357 1.0 1.2208899099917647 1.7484870750021198 23.040473043047278 -6.956431971037208 0.48310378171616647 0.9876987757063016 2.003790788039854 0.9996141147910936 0.006168270682780169 0.08100123259288852 0.026034789163045396 0.007486435342926442 0.04351826638158947 1.1055236277784167e-07 6.956431971037208 1.0160920123335526 DGADFAK(ub)WR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGADFAKWR 9 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78;P09972;A8MVZ9;J3KSV6;J3QKP5;K7EKH5;C9J8F3 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 1 73872000.0 16973000.0 21677000.0 35222000.0 True False 21971883.087848805 20470655.894385565 28811957.408239212 1.0 0.9316750782142351 1.311310336626231 24.389155184636365 -6.860331960728169 1.183936028463178 0.9628922972355709 1.3298215758761107 0.9540506465043691 0.03541813988985737 0.14646664844655627 0.3899072618886577 0.02332816751554534 0.05447980087308575 1.3793295464337384e-07 6.860331960728169 0.3669292786405398 DGDFENPVPYTGAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGDFENPVPYTGAVK 15 0 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 34904200.0 10565000.0 3132200.0 21207000.0 False True 10229619.857988615 4382903.794207216 15652250.503637174 1.0 0.42845226460536323 1.5300911197999079 23.286249198426294 -6.765685765234945 1.590812689227216 0.6703769365789493 1.535326464599239 0.713856406394956 0.24063462242523226 0.27345717766903666 1.3650216932411998 0.11927634212253344 0.2850836088813973 1.7151978939963633e-07 6.765685765234945 0.8649495280202898 DGDGTITTK(ub)ELGTVMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 DGDGTITTKELGTVMR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 101118700.0 40533000.0 28317400.0 32268300.0 True False 53139155.52213032 24092554.300360687 28929485.85539019 1.0 0.4533860966293886 0.544409966081268 25.6632719651729 -10.813179175055534 7.291948892732467 1.0217589633823467 0.49889803135532856 0.9758507827807931 0.03716033909513561 0.012100969438498253 0.00031002824049309187 0.03312242412154668 0.011993447871240062 1.5375201811720877e-11 10.813179175055534 -0.5228609320270181 DGDGTITTK(ub)ELGTVMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 DGDGTITTKELGTVMR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 128324600.0 38953000.0 40288600.0 49083000.0 True False 37716458.33679416 56376048.08227342 36226689.841562785 1.0 1.4947333490026016 0.960500838071054 25.168690874163175 -6.663413396631449 1.9609488720576551 1.317556036021988 0.9627195121871365 0.2501764056596264 0.210475766649455 0.47638132519408755 3.5249876849786803 0.08661328371198376 0.23339568853243461 2.1706340100697546e-07 6.663413396631449 -0.35483652383485154 DGDGTITTK(ub)ELGTVMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGDGTITTKELGTVMR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 106241000.0 32312000.0 47026000.0 26903000.0 True False 49019666.323620684 38633842.88418495 21585610.257996224 1.0 0.7881294545974662 0.4403459239296158 25.54685732803897 -6.963715995135203 0.3794442429933194 1.0240391484846698 0.1921485533889733 0.9998841809732048 0.002482906154337362 0.07839941708169247 0.016413145857873387 0.00452868572701222 0.029395238613623788 1.0871363189739681e-07 6.963715995135203 -0.8318905950956965 down DGDGTITTK(ub)ELGTVMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DGDGTITTKELGTVMR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 115666900.0 40533000.0 52021900.0 23112000.0 True False 55519145.46313843 49723400.44458166 17653421.60658137 1.0 0.895608173176858 0.3179699806133047 25.72648202669579 -6.93757177521946 0.6817775536520874 1.0068364939953154 0.1727297544373764 0.9978282681685829 0.013978208518969575 0.08889204087674786 0.05978610137960441 0.013368340669679995 0.05027113920191788 1.1545911513146605e-07 6.93757177521946 -0.834106739557939 down DGDGTITTK(ub)ELGTVMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DGDGTITTKELGTVMR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 119355100.0 38953000.0 47504900.0 32897200.0 True False 32391145.41049185 47248981.674715616 39775852.42053296 1.0 1.4587005515220572 1.2279853619393502 24.94909614959745 -10.133414776005093 4.530745298283706 0.9999593135527152 1.3433429567395927 0.7470185217659244 0.09418908176143763 10959185.118209932 24511194.608520687 2661.758190570446 0.03224342793300083 7.355043133716515e-11 10.133414776005093 0.34338364318687753 DGDGTITTK(ub)ELGTVMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGDGTITTKELGTVMR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 107667000.0 32312000.0 47955000.0 27400000.0 True False 41828520.964742295 45286262.09416707 22413481.14774157 1.0 1.0826646759119056 0.5358420673452483 25.31798365013142 -6.86838564545632 1.1426647549200168 1.046321332161632 0.5047934243754709 0.9630419481234849 0.04626721846936693 0.1384087481799444 0.3387778210117034 0.03145488744799225 0.07426567921681324 1.3539865633853014e-07 6.86838564545632 -0.5415279077861611 DGDSVMVLPTIPEEEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGDSVMVLPTIPEEEAK 17 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 29792200.0 7338800.0 3132400.0 19321000.0 False True 7105833.811056029 4383183.655250209 14260250.48242437 1.0 0.6168429732243914 2.0068370386367214 22.760572517102652 -6.833197280567367 1.3135066842787602 0.7956716978011996 2.046758064680314 0.9121256886164821 0.17376909741974528 0.17690129166949137 0.5957579994682133 0.10383391264532338 0.23896306170782147 1.468259161638363e-07 6.833197280567367 1.2510863668791146 up DGEAVWFGCDVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGEAVWFGCDVGK 13 0 Q13867;K7ESE8;J3KSD8 Q13867 BLMH Bleomycin hydrolase 0 9216900.0 1347600.0 3692600.0 4176700.0 False True 1766716.6501769624 3141678.4736420675 3744535.149735452 1.0 1.7782582585200535 2.1194882322303252 20.752639245227353 -10.16316725501501 0.1903152751888107 1.9654799858033276e-16 2.447555054607432 0.9994679922587048 0.010805944536831912 1.7490570047823966 0.09100100690397532 1.0945268685496248 0.2210129352820809 6.86803887914719e-11 10.16316725501501 2.447555054607432 DGEAVWFGCDVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGEAVWFGCDVGK 13 0 Q13867;K7ESE8;J3KSD8 Q13867 BLMH Bleomycin hydrolase 0 7965300.0 1347600.0 2711200.0 3906500.0 False True 1845844.1375206707 2591410.219260535 2983865.156892962 1.0 1.4039160547657645 1.6165314807678592 20.815849306750245 -10.849806113340545 0.11836359919284747 5.412980460691959e-16 2.042952799513395 0.9998237260631958 0.0033949417549322797 3.0135135066850394 0.06893739221243596 1.1102086528582478 0.27735447784748635 1.4131682994221288e-11 10.849806113340545 2.0429527995133947 DGEEAGAYDGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGEEAGAYDGPR 12 0 H7BZJ3;P30101 H7BZJ3;P30101 PDIA3 Protein disulfide-isomerase A3 0 8608550.0 1987700.0 741050.0 5879800.0 False True 1924601.551511973 1036955.129524699 4339703.989781008 1.0 0.5387895113718805 2.2548584076385696 20.876128366218527 -6.835163162454084 1.3046522218409577 0.7542971622845397 2.306111845251462 0.9158166991052729 0.21039083068589776 0.1745245126863804 0.5791168100760694 0.1265417899872212 0.29126016975592683 1.4616279443459138e-07 6.835163162454084 1.5518146829669224 up DGEFQELMK(ub)LALNQGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGEFQELMKLALNQGK 16 1 Q5T911;Q9NPJ6-2;Q9NPJ6 Q5T911 MED4 Mediator of RNA polymerase II transcription subunit 4 1 21531300.0 2403600.0 11707000.0 7420700.0 True False 3646436.9266976546 9617794.38279152 5953995.392391647 1.0 2.637586931059779 1.6328255532953373 21.798056008982385 -10.538383425978793 7.214256431164929 0.9994692952793832 2.135206242177542 0.6299053081912329 0.4101921147964489 0.0035027110170174135 0.00022412735093484926 0.39732148355120656 0.13238893577935396 2.894786736086829e-11 10.538383425978793 1.135736946898159 DGEFQELMK(ub)LALNQGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGEFQELMKLALNQGK 16 1 Q5T911;Q9NPJ6-2;Q9NPJ6 Q5T911 MED4 Mediator of RNA polymerase II transcription subunit 4 1 22319500.0 2403600.0 15108000.0 4807900.0 True False 3111507.5820393204 14267226.519000666 3932911.5332199507 1.0 4.585309899727048 1.2639890565981755 21.569182331074835 -6.628068260999697 2.0876580111473686 3.365390286250574 1.2772913717666596 0.11053628187738296 1.538663872220999 0.5640322633417773 4.682065222282153 0.6033682038250561 1.704516311974815 2.3546791539678092e-07 6.628068260999697 -2.0880989144839144 DGEPEPMQK(ub)LQDLVNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGEPEPMQKLQDLVNR 16 1 Q15291-2;Q15291 Q15291-2 RBBP5 Retinoblastoma-binding protein 5 1 18505600.0 7442100.0 5613200.0 5450300.0 True False 7205854.609099581 7854580.0324513065 4022702.924504815 1.0 1.0900275482289794 0.5582548001211307 22.780738112450646 -6.863327563968251 1.1687263699092931 1.0493520903876237 0.5308079888309535 0.9575629425766413 0.04787195251784329 0.1434178028852171 0.370358785749203 0.031900067205682225 0.0747700850192869 1.3698481767792372e-07 6.863327563968251 -0.5185441015566702 DGEPEPMQK(ub)LQDLVNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGEPEPMQKLQDLVNR 16 1 Q15291-2;Q15291 Q15291-2 RBBP5 Retinoblastoma-binding protein 5 1 31019500.0 8598700.0 14344000.0 8076800.0 True False 13044856.549174212 11784201.129816461 6480416.939812806 1.0 0.9033599630164155 0.49677947130994254 23.636977743519612 -6.943716008828958 0.6240356123465888 1.0044401201553517 0.3740097786542009 0.9986112359315561 0.008125550542459083 0.0861115134589575 0.04719157449724391 0.008153181282686134 0.03446213078675579 1.1383714393265792e-07 6.943716008828958 -0.6304303415011507 down DGEPEPMQK(ub)LQDLVNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGEPEPMQKLQDLVNR 16 1 Q15291-2;Q15291 Q15291-2 RBBP5 Retinoblastoma-binding protein 5 1 16694300.0 7442100.0 6922300.0 2329900.0 True False 6188435.890930648 6885008.195931038 2817071.3177595623 1.0 1.1125603169003073 0.4552153997245202 22.561143387884922 -6.862797326348718 1.1716169106707808 1.0615786965514962 0.4216550123838488 0.9569452330110981 0.059561170388449915 0.1439425464133352 0.3738932384907749 0.03960475896172004 0.09275411372367837 1.3715216694224946e-07 6.862797326348718 -0.6399236841676474 down DGEPVQGLTK(ub)EGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGEPVQGLTKEGEK 14 1 Q9NTJ4-2;Q9NTJ4;Q9NTJ4-4;Q9NTJ4-3;H3BMJ3;H3BUW3;H3BRI3;H3BQH9;B4DH23 Q9NTJ4-2 MAN2C1 Alpha-mannosidase 2C1 1 34845900.0 5666500.0 5418300.0 23761100.0 True False 8596494.776640149 4451362.031628875 19064708.1701399 1.0 0.5178112878896721 2.217730443104061 23.035317089696054 -6.830936256573048 1.3238561973541203 0.7425227484028929 2.2643106595020965 0.9077104661009363 0.2173073593210898 0.17965882920027582 0.6154926800945849 0.12887406119338585 0.29654863988563473 1.4759231455036822e-07 6.830936256573048 1.5217879110992036 up DGEPVQGLTK(ub)EGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGEPVQGLTKEGEK 14 1 Q9NTJ4-2;Q9NTJ4;Q9NTJ4-4;Q9NTJ4-3;H3BMJ3;H3BUW3;H3BRI3;H3BQH9;B4DH23 Q9NTJ4-2 MAN2C1 Alpha-mannosidase 2C1 1 22087600.0 5666500.0 8049000.0 8372100.0 True False 7335395.953413968 7601066.074360356 6848463.705000263 1.0 1.0362175569844654 0.9336188187377831 22.806443411788504 -6.811280189956181 1.4089944469354978 1.019708365478667 0.9317680968771033 0.8631920166806012 0.015714115368721047 0.20505112528562555 0.8020526525714198 0.008768577508260315 0.020273442441081774 1.544257822828489e-07 6.811280189956181 -0.08794026860156368 DGFGFIK(ub)CVDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGFGFIKCVDR 11 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 11056600.0 3523700.0 5163400.0 2369500.0 True False 4619604.823559343 4393040.846775557 2124326.86984896 1.0 0.950955983155022 0.4598503445609001 22.139338013286835 -6.926173588996306 0.7775575062226944 1.008621987453851 0.368196661095805 0.9957313101866462 0.015934763220004648 0.09467387774844731 0.08777412954170255 0.014199542877052008 0.045407332069809514 1.1852948870334319e-07 6.926173588996306 -0.6404253263580459 down DGFGFIK(ub)CVDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGFGFIKCVDR 11 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 9088300.0 4582500.0 2345000.0 2160800.0 True False 4437031.045833681 3281370.7290134504 1594821.6573895025 1.0 0.7395419809141562 0.3594344147956821 22.08116321703124 -6.965709430834848 0.34566021830748433 1.0386163988814996 0.04761874373467057 0.999927031049648 0.0022468103093739957 0.0777210362524653 0.014015674717038398 0.005278023569173776 0.03276754631379041 1.0821577378455325e-07 6.965709430834848 -0.990997655146829 down DGFGFIK(ub)CVDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGFGFIKCVDR 11 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 10248000.0 3523700.0 3833800.0 2890500.0 True False 4826507.114411988 3664410.0393187706 2207823.4317161427 1.0 0.7592260722825444 0.45743710293590256 22.202548074809727 -6.968069982502753 0.3007410666190778 1.0518814987626166 0.15531547818166333 0.9999631677508527 0.0013470945050128233 0.0769341236731033 0.011260157324770946 0.00498845829163926 0.027044910407393655 1.0762917652818193e-07 6.968069982502753 -0.8965660205809532 down DGFGFIK(ub)CVDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGFGFIKCVDR 11 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 11629400.0 4582500.0 3466300.0 3580600.0 True False 3810551.789171027 3447626.35389332 4329286.905176135 1.0 0.9047577738454881 1.1361312336652316 21.861568492465516 -6.79490901267341 1.4764631453631043 0.9471068801860862 1.1389429255916808 0.81689938421955 0.04062858572346119 0.2281071951992457 0.9821329122080151 0.021652942435880868 0.050524091415776365 1.6035813155059485e-07 6.79490901267341 0.1918360454055945 DGFGFIK(ub)CVDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGFGFIKCVDR 11 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 35202900.0 9184900.0 11529000.0 14489000.0 True False 11890034.111446565 10887401.015194498 11852150.669694453 1.0 0.9156744979152894 0.9968138491952987 23.50324951826434 -10.459330116705905 5.756617297263845 1.0000337757179323 0.9562441735647667 0.27940709267541886 0.033125001449410774 1.4370324515003055e-05 1.3496560425305765e-06 0.03209789722773766 0.010691048246388689 3.472720920037157e-11 10.459330116705905 -0.04378960215316563 DGFIDKEDLHDMLASLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGFIDKEDLHDMLASLGK 18 1 J3QRS3;P19105;O14950;P24844;J3KTJ1 J3QRS3 MYL12A;MYL12B;MYL9 Myosin regulatory light chain 12A;Myosin regulatory light chain 12B;Myosin regulatory light polypeptide 9 0 23623900.0 10784000.0 2471900.0 10368000.0 False True 10441667.822863158 3458942.5607882054 7652309.766667148 1.0 0.3312634168666501 0.732862785570672 23.31584883278585 -10.797827471288237 6.878498940947564 1.01903460057071 0.5320631012190356 0.6441538197711638 0.16395225572478353 0.0456560461192814 0.001341918851768971 0.15144141547403248 0.05291536299960221 1.5928413767934404e-11 10.797827471288237 -0.4869714993516745 DGFIDLMELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGFIDLMELK 10 0 Q96C19;H0Y4Y4;A0A087X1Z2;Q9BUP0-2;Q9BUP0 Q96C19 EFHD2;EFHD1 EF-hand domain-containing protein D2;EF-hand domain-containing protein D1 0 3694830.0 442130.0 1316100.0 1936600.0 False True 579636.7115930103 1119743.0101176181 1736219.2091789364 1.0 1.9318013985695255 2.9953575652710143 19.14478944606717 -6.969399909329644 0.27213648942985685 0.742362093974269 4.216862258002585 0.9999773168028919 0.0038825058749195696 0.07649790651160548 0.009724836089485895 0.0205788637209332 0.09862888591336194 1.0730009109487023e-07 6.969399909329644 3.474500164028316 DGFSPCCPGWSQTPELK(ub)PSACLDLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGFSPCCPGWSQTPELKPSACLDLPK 26 1 Q5LJA5;Q5LJA9 Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase 1 49446000.0 10050000.0 15180000.0 24216000.0 True False 13175647.324338444 12915203.171176564 21710360.616274457 1.0 0.9802329140458412 1.6477642488328024 23.651370507946613 -6.9000791320506725 0.9607997653531151 0.9723058821482145 1.7179374152497426 0.9866044007619833 0.035893454760814264 0.11134672466779202 0.17710671479127169 0.028015240216083603 0.07291726490845994 1.258696046056716e-07 6.9000791320506725 0.7456315331015282 DGFSPCCPGWSQTPELK(ub)PSACLDLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGFSPCCPGWSQTPELKPSACLDLPK 26 1 Q5LJA5;Q5LJA9 Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase 1 77277000.0 10050000.0 16338000.0 50889000.0 True False 13765756.59103796 15616133.137458919 38870066.29185363 1.0 1.1344188046754817 2.823678163622299 23.714580569469504 -6.922738836910245 0.8041580575051918 0.9662778066962798 3.1140148446024947 0.9949084381579536 0.0592122260848886 0.09658683013526632 0.09746090871062775 0.05177184466073634 0.15938414518323246 1.194706325423767e-07 6.922738836910245 2.147737037906215 up DGGAWGTEQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGGAWGTEQR 10 0 P09382 P09382 LGALS1 Galectin-1 0 11897800.0 2521400.0 1006600.0 8369800.0 False True 2441359.537144583 1408540.6293496552 6177498.291382202 1.0 0.5769492808900593 2.5303517148512302 21.21925334468051 -6.849997866376442 1.2350319786445 0.7742384924765934 2.608467875778955 0.9403119659999778 0.20500051942342928 0.1574588022405933 0.46216323644420143 0.1298828230490861 0.3005687847396114 1.4125444842245934e-07 6.849997866376442 1.8342293833023615 up DGGK(ub)DGAGTQGGEESQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGGKDGAGTQGGEESQSR 18 1 Q9BRZ2 Q9BRZ2 TRIM56 E3 ubiquitin-protein ligase TRIM56 1 8666500.0 1624900.0 4235400.0 2806200.0 True False 2130259.635553985 3603494.829459891 2515841.3429711545 1.0 1.691575416121887 1.181002212585649 21.02259784583101 -10.624919801000244 4.894183084649328 0.9936311222419548 1.4362888143537753 0.4933061274838597 0.2084406375003529 0.014621153336483082 0.0011205347553168807 0.20371473494109751 0.06727392647597337 2.3718116558733454e-11 10.624919801000244 0.4426576921118205 DGGK(ub)DGAGTQGGEESQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGGKDGAGTQGGEESQSR 18 1 Q9BRZ2 Q9BRZ2 TRIM56 E3 ubiquitin-protein ligase TRIM56 1 7196800.0 1624900.0 3074900.0 2497000.0 True False 2225669.4412714024 2939040.750665468 1907260.0273292537 1.0 1.3205198832161509 0.8569376889318034 21.085807907353903 -6.720728102627551 1.7568445682972813 1.1948531122668007 0.8576391644888747 0.51584805441025 0.134864449309222 0.35392333849030694 2.1352990821723257 0.06094517351312428 0.15285568510382638 1.902268854638973e-07 6.720728102627551 -0.337213947777926 DGGK(ub)DGAGTQGGEESQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGGKDGAGTQGGEESQSR 18 1 Q9BRZ2 Q9BRZ2 TRIM56 E3 ubiquitin-protein ligase TRIM56 1 3373590.0 1319200.0 1493000.0 561390.0 True False 1096973.2504690504 1484956.9126627012 678774.0534259144 1.0 1.353685618156828 0.6187699227266299 20.065096915588374 -6.775818540100626 1.5519500585611363 1.201351405411448 0.613671799568823 0.7523952268019738 0.1493286220243581 0.25712223603252243 1.2228528672074435 0.07580549255016208 0.17952018619064344 1.6756428583733226e-07 6.775818540100626 -0.587679605842625 DGGLICTSCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGGLICTSCR 10 0 P31146;H3BRY3;H3BTU6;H3BRJ0 P31146 CORO1A Coronin-1A;Coronin 0 24310300.0 1738300.0 11188000.0 11384000.0 False True 2278928.1337211435 9518794.01048242 10206092.883038845 1.0 4.176873271970922 4.478461927789643 21.11992399907925 -10.018401061162603 0.5472483220908725 6.265571690010367e-14 4.456966343816216 0.9994000733677767 0.038540413082275946 1.2970450917921714 0.2547682851372659 2.229290161462393 0.05631550263136319 9.585150556306202e-11 10.018401061162603 4.456966343816153 DGGLICTSCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGGLICTSCR 10 0 P31146;H3BRY3;H3BTU6;H3BRJ0 P31146 CORO1A Coronin-1A;Coronin 0 21087200.0 1738300.0 8527900.0 10821000.0 False True 2380996.4857911705 8151109.180005881 8265302.66549054 1.0 3.423402440385117 3.4713628158691296 21.183134060602143 -10.47908359426072 0.7510623750615179 1.1350107492595369e-13 3.4620060924017246 0.9999531498023849 0.007897938495743292 1.8967713997945312 0.3894119013083664 3.7487779200795894 0.007157997145731267 3.318305796932885e-11 10.47908359426072 3.462006092401611 DGGLQNMELHGMIMLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGGLQNMELHGMIMLR 16 0 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 0 29755500.0 4090500.0 14788000.0 10877000.0 False True 6205587.555606898 12148965.860828644 8727156.182441548 1.0 1.957746265275358 1.406338417472871 22.5651363829723 -10.567442554457287 5.141069920020984 0.9959261667039959 1.6820423413741155 0.6710451885996358 0.225111311213741 0.010549382289855566 0.0008875986931264736 0.21875306586744472 0.07265436328114196 2.7074313009756752e-11 10.567442554457287 0.6861161746701195 DGGLQNMELHGMIMLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGGLQNMELHGMIMLR 16 0 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 0 15952700.0 4090500.0 6653200.0 5209000.0 False True 5295232.885809546 6282943.57136716 4261015.4488535 1.0 1.1865282805982973 0.8046889609468172 22.33626270506475 -6.773857636284467 1.5595289524831286 1.1064589195787298 0.8022126361487153 0.7451524196523222 0.07870160144885667 0.26023628078007244 1.2495737056497598 0.039764175522875436 0.09433044753944488 1.683225739732561e-07 6.773857636284467 -0.3042462834300145 DGGQTESNEEGK(ub)ENR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGGQTESNEEGKENR 15 1 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77;Q5VU81;Q5VU80;Q5VU79;Q5VU78 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 1 10121900.0 3384100.0 3524300.0 3213500.0 True False 3276673.597862689 4931571.368981704 2371787.9470664402 1.0 1.5050542025908449 0.7238401617462026 21.643800536926214 -6.732203803928385 1.7154985342617721 1.3031988055937118 0.7241421980514053 0.5693057369073461 0.21227829724052294 0.3321290860555902 1.915923170314788 0.09802682248838485 0.24261414151244 1.8526620097777354e-07 6.732203803928385 -0.5790566075423065 DGGSVVGASVFYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGGSVVGASVFYK 13 0 O60271-9;O60271-4;O60271;A0A087X2D8;O60271-2;O60271-5;O60271-3 O60271-9 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 0 4171310.0 1701200.0 964910.0 1505200.0 False True 2230289.674444237 820949.1891897202 1349456.3428979325 1.0 0.3680908352832201 0.6050587770551383 21.088799671731362 -10.230968556761647 5.506105798107543 1.0000299301357902 0.4865748061691797 0.8622424236710969 0.09674175712323485 3.5546248760646205e-05 4.964836656301741e-06 0.09367525030210226 0.03122326785174512 5.875318887286945e-11 10.230968556761647 -0.5134551239666105 DGHLNKPICIAWSSSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGHLNKPICIAWSSSGR 17 1 Q96JH7 Q96JH7 VCPIP1 Deubiquitinating protein VCIP135 0 8028800.0 2746400.0 2696300.0 2586100.0 False True 3600556.996175432 2294022.5500950827 2318515.1796228685 1.0 0.637129908659085 0.6439323643774093 21.779788674062853 -10.47176978631468 9.21200244292038 1.0000048933159664 0.640531136518355 0.9997314931291957 0.002777090917962014 2.790958207846722e-07 1.600233680722161e-08 0.002688943272256605 0.0008963022396808988 3.3746614753740555e-11 10.47176978631468 -0.3594737567976114 DGHLNKPICIAWSSSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGHLNKPICIAWSSSGR 17 1 Q96JH7 Q96JH7 VCPIP1 Deubiquitinating protein VCIP135 0 5088500.0 2746400.0 0.0 2342100.0 False True 3761818.298669318 0.0 1788944.2170636146 1.0 0.0 0.47555306371294553 21.842998735585745 -10.3253501388094 6.810817087832508 1.0000193716009118 0.237776531856475 0.7740293527265159 0.1941437252856626 5.710846818685798e-05 5.6569317813086e-06 0.18798361209754202 0.06265961790016988 4.727699466025131e-11 10.3253501388094 -0.7622428397444369 DGIDDESYEAIFKPVMSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGIDDESYEAIFKPVMSK 18 1 Q13547 Q13547 HDAC1 Histone deacetylase 1 0 137921000.0 40172000.0 53675000.0 44074000.0 False True 60943860.96659097 44096276.88531088 35362754.58167955 1.0 0.7235556819986212 0.5802513004724985 25.860977565957402 -13.999999999998868 0.08343113051186483 2.4615854735927525 0.17820721894056812 0.9998721309670936 0.0019699602010014483 12.224934173768862 0.08225076899425333 3.248576902243919 0.3636413362489269 1.0000000000026054e-14 13.999999999998868 -2.2833782546521846 DGIDDESYEAIFKPVMSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGIDDESYEAIFKPVMSK 18 1 Q13547 Q13547 HDAC1 Histone deacetylase 1 0 96181000.0 40172000.0 40444000.0 15565000.0 False True 52003445.90850536 38193255.846866705 12732329.710386766 1.0 0.7344370200787032 0.24483626975004644 25.63210388804985 -7.081508407748409 0.44369551765477266 1.017859069985951 1.943369424162781e-13 0.9997302722581385 0.005136971493308997 0.07495174688486111 0.022958554439560876 0.007053088366302947 0.03838818111580743 8.288798693714022e-08 7.081508407748409 -1.0178590699857568 down DGIDDESYGQIFK(ub)PIISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGIDDESYGQIFKPIISK 18 1 Q92769-3;Q92769 Q92769-3 HDAC2 Histone deacetylase 2 1 22741700.0 6169400.0 9049900.0 7522400.0 True False 8088143.144554582 7699690.196233907 6744054.207956034 1.0 0.9519725428472164 0.8338198381783748 22.947377099714405 -6.955805958582849 0.4909930842861229 1.0025625648837524 0.7782112193565665 0.9995816110345022 0.001428272946951082 0.08123487491944555 0.02693754108351922 0.0017047998102060454 0.009744888419385525 1.1071183304983481e-07 6.955805958582849 -0.22435134552718594 DGIDDESYGQIFK(ub)PIISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGIDDESYGQIFKPIISK 18 1 Q92769-3;Q92769 Q92769-3 HDAC2 Histone deacetylase 2 1 38480000.0 11556000.0 12388000.0 14536000.0 True False 11189161.105434585 17334593.002566565 10728585.529347362 1.0 1.5492307992729801 0.9588373451997647 23.415598540168606 -6.662404859905005 1.9642301283631458 1.3528317246070587 0.9612824824281193 0.24589558089327412 0.23371651261355517 0.478791771935199 3.5535587794281027 0.09604420312570391 0.25918090221746565 2.1756806041733945e-07 6.662404859905005 -0.3915492421789394 DGIDDESYGQIFK(ub)PIISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGIDDESYGQIFKPIISK 18 1 Q92769-3;Q92769 Q92769-3 HDAC2 Histone deacetylase 2 1 27161800.0 6169400.0 8045400.0 12947000.0 True False 8450393.901766125 7689927.625420011 9889185.251834938 1.0 0.9100081859867885 1.1702632287671355 23.010587161237297 -6.81333123221154 1.400490172616688 0.9511450849658946 1.1751714856841489 0.8683497104241846 0.039157354787255697 0.20229035538578527 0.7813361926638781 0.021980993470910457 0.0507740745265549 1.5369819518539817e-07 6.81333123221154 0.2240264007182543 DGIDDESYGQIFK(ub)PIISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGIDDESYGQIFKPIISK 18 1 Q92769-3;Q92769 Q92769-3 HDAC2 Histone deacetylase 2 1 37955000.0 11556000.0 15249000.0 11150000.0 True False 9609326.017601825 15166850.610310499 13481413.448224848 1.0 1.5783469706958335 1.4029509898540595 23.196003815602882 -10.123554213088486 4.371404169832313 0.9999313609261063 1.4906489803075313 0.912539783349431 0.07160510946946114 10671471.921125257 12356816.28141824 5967.664065965378 0.024512333600241326 7.523948026803495e-11 10.123554213088486 0.490717619381425 DGIDDESYGQIFK(ub)PIISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGIDDESYGQIFKPIISK 18 1 Q92769-3;Q92769 Q92769-3 HDAC2 Histone deacetylase 2 1 54167000.0 16230000.0 18362000.0 19575000.0 True False 21010054.94112923 17340138.558504745 16012550.85646136 1.0 0.8253257122407488 0.7621375051768775 24.32457659886367 -13.999999999999998 0.14148344062999585 1.835547565895837 0.6853189084462421 0.9995970833487662 0.002019304745187919 11.935819882632325 0.11795538591161192 2.7511424642330446 0.0687456948612717 1.0000000000000041e-14 13.999999999999998 -1.1502286574495948 DGITAGK(ub)AALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGITAGKAALR 11 1 O00481-2;O00481-3;O00481;O00481-4;E7EPR2;P78410-3;P78410-2;P78410;C9JUV8;O00478-2;O00478;C9JNZ3;E9PRX1;C9JVU4;C9J3Q8;C9J877;E9PJE9;E9PRR1;C9JZT5;C9JQT8 O00481-2;P78410-3 BTN3A1;BTN3A2;BTN3A3 Butyrophilin subfamily 3 member A1;Butyrophilin subfamily 3 member A2;Butyrophilin subfamily 3 member A3 1 11360120.0 883250.0 381870.0 10095000.0 True False 1209811.3939337605 364997.7207247789 7710768.913051191 1.0 0.3016980353755564 6.373529751591487 20.206350722406505 -6.8782791832499575 1.0893941342023883 0.5763478656488682 6.789813744773006 0.9722687772692675 0.45174076345709996 0.12916330181035066 0.28161382080182634 0.3199188545107315 0.7703480613058599 1.3234904648398052e-07 6.8782791832499575 6.213465879124137 up DGIVLGADTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGIVLGADTR 10 0 Q99436;Q5TBG5;Q99436-2 Q99436 PSMB7 Proteasome subunit beta type-7;Proteasome subunit beta type 0 37902300.0 10632000.0 9954300.0 17316000.0 False True 13938654.960434455 8469157.241557486 15524306.426800825 1.0 0.6076021872696897 1.1137592881714424 23.732588016269133 -6.699760631807721 1.8318175264993293 0.7562757160504993 1.1122412423653172 0.41637031954335235 0.16564381310973428 0.3960358551300904 2.5834694691043416 0.07214599342948931 0.185588797808431 1.9963623381018998e-07 6.699760631807721 0.3559655263148179 DGIVLGADTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGIVLGADTR 10 0 Q99436;Q5TBG5;Q99436-2 Q99436 PSMB7 Proteasome subunit beta type-7;Proteasome subunit beta type 0 10116200.0 7755500.0 2360700.0 0.0 False True 7509305.897646067 3303339.820887866 0.0 1.0 0.43989948817018626 0.0 22.840248131617344 -8.12926559730785 0.5580946540186298 1.021936534331518 1.2118817797476157e-16 0.9906381630984629 0.039595715683012116 0.11879754261953636 0.1701929953088396 0.05043955566152965 0.07426977441419738 7.425648757327226e-09 8.12926559730785 -1.0219365343315179 DGIVLGADTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGIVLGADTR 10 0 Q99436;Q5TBG5;Q99436-2 Q99436 PSMB7 Proteasome subunit beta type-7;Proteasome subunit beta type 0 28867800.0 10632000.0 12008000.0 6227800.0 False True 14562937.718996571 11477446.854854127 4756921.905567135 1.0 0.7881271674933014 0.3266457631939183 23.795798077792025 -6.9583426856730535 0.45819412649894914 1.013696686904986 0.0825292888883687 0.9997037050946127 0.004838993742309157 0.08029855515233611 0.023359628399752478 0.0062484337840019956 0.03813076257428078 1.1006704685449264e-07 6.9583426856730535 -0.9311673980166172 down DGIVLGADTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGIVLGADTR 10 0 Q99436;Q5TBG5;Q99436-2 Q99436 PSMB7 Proteasome subunit beta type-7;Proteasome subunit beta type 0 15496800.0 7755500.0 5148300.0 2593000.0 False True 6449041.876904722 5120565.086042461 3135184.3113226085 1.0 0.7940040061424014 0.48614730236910314 22.62065340705162 -6.965318488140912 0.3525445419822955 1.0288930283775377 0.24082938684848887 0.999919559143728 0.0018937608444959146 0.07785305473140802 0.014479864750791226 0.0041992594739345785 0.026417078391265704 1.0831323118999046e-07 6.965318488140912 -0.7880636415290488 down DGIVLGADTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGIVLGADTR 10 0 Q99436;Q5TBG5;Q99436-2 Q99436 PSMB7 Proteasome subunit beta type-7;Proteasome subunit beta type 0 15702200.0 2523700.0 8162900.0 5015600.0 False True 3266979.399564252 7708627.43923421 4102812.2644019183 1.0 2.3595580187197944 1.2558427105322885 21.639525926995713 -6.59439197569559 2.2115366347188035 1.9176057622111924 1.2591770125477006 0.004882788164588203 0.5884771200776572 0.6567944091503108 6.062149559724337 0.2215484614993164 0.6554869437404305 2.544532629135116e-07 6.59439197569559 -0.6584287496634917 DGK(ub)DQGVNVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGKDQGVNVR 10 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1;D6RFG3;D6REL6;I6L9I8;Q9H201-2;Q9H201 Q9Y6I3-3 EPN1;EPN3 Epsin-1;Epsin-3 1 24982700.0 8842400.0 10850000.0 5290300.0 True False 11592472.029923413 9231222.292968748 4742910.504140934 1.0 0.7963118021022937 0.4091371100053686 23.46668491002344 -6.961027504114564 0.42070577790507885 1.0169843521257693 0.1738425208484518 0.9998064210805419 0.0034096504260798218 0.07933614746574914 0.019790373946889386 0.005010721959837003 0.032223061768879464 1.0938870875919697e-07 6.961027504114564 -0.8431418312773176 down DGK(ub)DQGVNVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGKDQGVNVR 10 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1;D6RFG3;D6REL6;I6L9I8;Q9H201-2;Q9H201 Q9Y6I3-3 EPN1;EPN3 Epsin-1;Epsin-3 1 27568000.0 10072000.0 10663000.0 6833000.0 True False 9752269.873134062 14920791.506810408 5043232.314393958 1.0 1.5299813992960545 0.5171342036265069 23.217306619323008 -6.76452141403943 1.5953509875247636 1.3061140957570376 0.5125743719968177 0.7091434149879636 0.22308189678449136 0.27541033900866607 1.3824306327890925 0.11027553562771698 0.2638506947531087 1.7198025397293675e-07 6.76452141403943 -0.79353972376022 DGK(ub)DQGVNVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGKDQGVNVR 10 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1;D6RFG3;D6REL6;I6L9I8;Q9H201-2;Q9H201 Q9Y6I3-3 EPN1;EPN3 Epsin-1;Epsin-3 1 31321900.0 7657900.0 13204000.0 10460000.0 True False 11617594.167481266 10847643.036677139 8392576.415219136 1.0 0.9337254237233306 0.7224022714367785 23.469808003005312 -6.950073022207919 0.558047689318021 1.0027925846168253 0.6432695394115692 0.9992069553964312 0.003333513121831385 0.08345655954966479 0.035842044511098424 0.003581820186242497 0.017559299770356272 1.121829814149672e-07 6.950073022207919 -0.35952304520525613 DGK(ub)DQGVNVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGKDQGVNVR 10 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1;D6RFG3;D6REL6;I6L9I8;Q9H201-2;Q9H201 Q9Y6I3-3 EPN1;EPN3 Epsin-1;Epsin-3 1 16480200.0 8842400.0 7637800.0 0.0 True False 12111674.236875035 7300336.7411729535 0.0 1.0 0.6027520719593373 0.0 23.52989497154633 -7.644959120637112 0.6635400932311148 0.9981042826458895 3.3430504456330613e-21 0.9872538024646403 0.0464141314873838 0.1210495236522934 0.148595126320916 0.042532388916917 0.0775425974484644 2.2648574845444625e-08 7.644959120637112 -0.9981042826458895 down DGK(ub)DQGVNVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGKDQGVNVR 10 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1;D6RFG3;D6REL6;I6L9I8;Q9H201-2;Q9H201 Q9Y6I3-3 EPN1;EPN3 Epsin-1;Epsin-3 1 26973500.0 10072000.0 12524000.0 4377500.0 True False 8375314.265254901 12456530.726180641 5292815.010726842 1.0 1.4872911429552822 0.631954198146827 22.997711894757284 -6.752191423230201 1.6418503114218996 1.2857822733534592 0.6299805800524594 0.6582681022964856 0.20478901479091985 0.2962550766104231 1.57192552355929 0.09850665293644034 0.23858902017116787 1.7693289223631567e-07 6.752191423230201 -0.6558016933009998 DGK(ub)DQGVNVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGKDQGVNVR 10 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1;D6RFG3;D6REL6;I6L9I8;Q9H201-2;Q9H201 Q9Y6I3-3 EPN1;EPN3 Epsin-1;Epsin-3 1 24249200.0 7657900.0 11992000.0 4599300.0 True False 9913302.50977655 11324634.65818479 3762274.5928032114 1.0 1.1423675053814182 0.37951778321027096 23.24093432509776 -6.858477023552818 1.1934902035866002 1.0769454600483745 0.34365130191865323 0.9517570013988056 0.07274445075456712 0.14837435226289275 0.4024822780720087 0.04756931830205105 0.11085150961413173 1.3852334700739821e-07 6.858477023552818 -0.7332941581297213 down DGK(ub)PVIEYQEEELLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGKPVIEYQEEELLDK 16 1 P86790;P86791 P86790 CCZ1B;CCZ1 Vacuolar fusion protein CCZ1 homolog B;Vacuolar fusion protein CCZ1 homolog 1 7303600.0 1416500.0 1230000.0 4657100.0 True False 1371533.9828528983 1721145.414365265 3437265.7999947504 1.0 1.254905409478187 2.506147017112159 20.38735893798209 -6.940217310353779 0.6575375383798274 0.9860059647255035 2.845736450540088 0.9981922406817859 0.02798524185463812 0.08766760861637277 0.054158992711803446 0.027286612978835507 0.10758914317892271 1.1475792571721858e-07 6.940217310353779 1.8597304858145844 up DGK(ub)VLANPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGKVLANPR 9 1 Q9NPF4;G3V445 Q9NPF4 OSGEP Probable tRNA N6-adenosine threonylcarbamoyltransferase 1 5808000.0 2412800.0 2304900.0 1090300.0 True False 2336206.9846999496 3225258.5898947087 804717.7217011169 1.0 1.3805534402633182 0.34445480514838483 21.155736669985295 -6.807273867882551 1.4258256378572771 1.2080768565882316 0.3274136631331124 0.8526274424356022 0.1642758302401953 0.21053921400819997 0.8440682827534569 0.09060454031497067 0.20987081892863332 1.558569352640412e-07 6.807273867882551 -0.8806631934551192 down DGK(ub)VLANPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGKVLANPR 9 1 Q9NPF4;G3V445 Q9NPF4 OSGEP Probable tRNA N6-adenosine threonylcarbamoyltransferase 1 5987130.0 2412800.0 3183400.0 390930.0 True False 2006350.1051635277 3166250.392344574 472671.6555439056 1.0 1.5781145993393355 0.235587824042993 20.93614194541957 -6.789664995068543 1.4975014168788785 1.3232473563995193 0.2214069243386928 0.8002912003022891 0.2457170432921798 0.23584970388826743 1.04483200689889 0.12915172444324907 0.30247186151269617 1.6230616075835532e-07 6.789664995068543 -1.1018404320608264 down DGKPPYSYASLITFAINSSPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGKPPYSYASLITFAINSSPK 21 1 H7C1Y6;C9JVP0;Q9UPW0-2;Q9UPW0 H7C1Y6 FOXJ3 Forkhead box protein J3 0 4401190.0 2211700.0 815490.0 1374000.0 False True 2141490.7941233707 1141119.4097241694 1014108.1808835514 1.0 0.5328621597886868 0.47355243537186503 21.030184044684763 -13.999999999999998 0.29100041131268495 5.048092672242818 0.45755262752833376 0.9996297012705802 0.004530578023682792 16.025463459713922 0.171090072952075 38.858401017749536 0.02229904259787068 1.0000000000000041e-14 13.999999999999998 -4.590540044714484 DGLAFNALIHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGLAFNALIHR 11 0 O43707;Q9H254-4;Q9H254-2;M0QZQ3;C9JY79;Q9H254 O43707 ACTN4;SPTBN4 Alpha-actinin-4;Spectrin beta chain, non-erythrocytic 4 0 46246000.0 16146000.0 14772000.0 15328000.0 False True 21167562.358086437 12568075.180804994 13742005.59655829 1.0 0.5937422065041766 0.6492011391811757 24.335351803354534 -10.237362166230579 5.466289500557318 1.0000256625141604 0.6214716728428366 0.984155761382688 0.022641014456426314 7.0813809344095414e-06 9.87963018435971e-07 0.021923551714832474 0.007307355994235188 5.7894570149778984e-11 10.237362166230579 -0.3785539896713238 DGLAFNALIHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGLAFNALIHR 11 0 O43707;Q9H254-4;Q9H254-2;M0QZQ3;C9JY79;Q9H254 O43707 ACTN4;SPTBN4 Alpha-actinin-4;Spectrin beta chain, non-erythrocytic 4 0 56323000.0 17371000.0 10811000.0 28141000.0 False True 16819567.11340465 15127888.678620229 20770027.88809608 1.0 0.899421999188302 1.234872916054007 24.003637239520348 -6.8263224796561435 1.3442206997916144 0.9461061336132743 1.24324276335635 0.898325835275472 0.044818813473309356 0.18539283232638717 0.656429292092745 0.02618783702317807 0.06028407818839563 1.4916863661543056e-07 6.8263224796561435 0.29713662974307575 DGLAFNALIHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGLAFNALIHR 11 0 O43707;Q9H254-4;Q9H254-2;M0QZQ3;C9JY79;Q9H254 O43707 ACTN4;SPTBN4 Alpha-actinin-4;Spectrin beta chain, non-erythrocytic 4 0 41249000.0 16146000.0 11656000.0 13447000.0 False True 22115612.52924369 11140999.37876249 10271095.549658176 1.0 0.5037617368287058 0.46442736035805504 24.398561864877426 -13.999999999999998 0.35936247709780944 7.467169020463464 0.45964788097074705 0.9997721338677134 0.00367915321895736 21.62793107042069 0.19368453101039176 107.2407834437035 0.011374057862773446 1.0000000000000041e-14 13.999999999999998 -7.007521139492717 DGLAFNALIHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGLAFNALIHR 11 0 O43707;Q9H254-4;Q9H254-2;M0QZQ3;C9JY79;Q9H254 O43707 ACTN4;SPTBN4 Alpha-actinin-4;Spectrin beta chain, non-erythrocytic 4 0 31769200.0 17371000.0 6309800.0 8088400.0 False True 14444756.165780656 6275807.855002759 9779647.043463862 1.0 0.4344696291841897 0.6770378766677733 23.784042514954624 -10.332078735891978 5.810319922302501 1.0000584504070922 0.5557537529259852 0.8172571618046313 0.09902807235599335 7.499015155721308e-05 8.620429143416787e-06 0.0958960750194182 0.031961172920148016 4.655016922351518e-11 10.332078735891978 -0.444304697481107 DGLCSK(ub)TVEYHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGLCSKTVEYHR 12 1 Q8NC54 Q8NC54 KCT2 Keratinocyte-associated transmembrane protein 2 1 21264200.0 5511000.0 7485500.0 8267700.0 True False 7224974.368599919 6368692.578250468 7412237.713378455 1.0 0.881483068774487 1.0259188939953048 22.784561038825466 -6.688675780241088 1.871300057564068 0.9256035561918415 1.0254090831353968 0.3641179346162282 0.05013817679328933 0.41954127474954606 2.847396069935352 0.021443367354777452 0.05592970325592255 2.0479729672493626e-07 6.688675780241088 0.09980552694355527 DGLCSK(ub)TVEYHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGLCSKTVEYHR 12 1 Q8NC54 Q8NC54 KCT2 Keratinocyte-associated transmembrane protein 2 1 10981600.0 4618300.0 2967400.0 3395900.0 True False 4471694.594429613 4152298.29478657 2506411.915183733 1.0 0.9285737670812951 0.5605060592255046 22.092390228402483 -6.939135430423955 0.6675661704892403 1.0041996403358124 0.46372702553928 0.9980483337655487 0.008507057115908132 0.08816354234847058 0.05642424771494874 0.00822765084982296 0.031801494754308046 1.1504415792129833e-07 6.939135430423955 -0.5404726147965324 DGLCSK(ub)TVEYHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGLCSKTVEYHR 12 1 Q8NC54 Q8NC54 KCT2 Keratinocyte-associated transmembrane protein 2 1 30495000.0 17499000.0 12996000.0 0.0 True False 26547262.348261856 10676762.26178855 0.0 1.0 0.4021794082465003 0.0 24.662059756870804 -8.272254448654195 0.5381847807741026 1.0317177883042843 4.896060924857824e-19 0.9917948330358257 0.03721525743073879 0.1439335816187653 0.17586593394210054 0.05825795399922213 0.07162866167243144 5.342512553876908e-09 8.272254448654195 -1.0317177883042843 DGLCSK(ub)TVEYHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGLCSKTVEYHR 12 1 Q8NC54 Q8NC54 KCT2 Keratinocyte-associated transmembrane protein 2 1 18516400.0 5511000.0 5905100.0 7100300.0 True False 7548565.629175146 5644193.156445627 5423355.375268677 1.0 0.7477173060045825 0.7184617107000371 22.847771100348357 -13.999999999999998 0.3040484070852948 3.355621521373641 0.7115608404101217 0.9996588414552577 0.0023344470376466795 16.856761890538678 0.17523989936755646 25.038064431511717 0.010391950684779064 1.0000000000000041e-14 13.999999999999998 -2.644060680963519 DGLCSK(ub)TVEYHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGLCSKTVEYHR 12 1 Q8NC54 Q8NC54 KCT2 Keratinocyte-associated transmembrane protein 2 1 14870900.0 4618300.0 4611500.0 5641100.0 True False 3840321.075379938 4586656.934188914 6820627.928500557 1.0 1.1943420469693768 1.7760566876106227 21.87279550383676 -6.951501324819983 0.5421116702104395 0.9915526080784144 2.005807084175331 0.9993138919269221 0.008636516858236784 0.0828884438537768 0.0335103985194066 0.009471877960316444 0.04819073684746859 1.1181464136613691e-07 6.951501324819983 1.0142544760969168 DGLEMEK(ub)C ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGLEMEKC 8 1 P13693;J3KPG2;P13693-2 P13693 TPT1 Translationally-controlled tumor protein 1 15200500.0 5231700.0 3730500.0 6238300.0 True False 7936871.388502297 3064763.128470464 5005297.270655982 1.0 0.3861424708116369 0.6306385760397828 22.92013899712272 -10.29007820773774 5.677686552134137 1.0000458043614426 0.5083905234257245 0.8435196321947837 0.09981511698448327 5.7878337407249395e-05 7.237022367805632e-06 0.09665454113844217 0.03221519048171782 5.127690362434095e-11 10.29007820773774 -0.4916552809357181 DGLEMEK(ub)C ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGLEMEKC 8 1 P13693;J3KPG2;P13693-2 P13693 TPT1 Translationally-controlled tumor protein 1 5257040.0 2664000.0 1731600.0 861440.0 True False 3648952.7918930496 1655092.1863645425 657985.6139137017 1.0 0.4535800490600189 0.18032176666564756 21.799051055587114 -9.107728467427549 0.24819655687963643 1.3383201999965966 7.967507176327698e-24 0.9991583972910757 0.009885866542311739 0.5497595348666794 0.08706198327193677 0.27215331070103727 0.11417313394238415 7.803178337025209e-10 9.107728467427549 -1.3383201999965966 DGLEMEK(ub)C ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGLEMEKC 8 1 P13693;J3KPG2;P13693-2 P13693 TPT1 Translationally-controlled tumor protein 1 3613040.0 1760700.0 1157700.0 694640.0 True False 1464100.0622353351 1151463.2403145414 839886.0123475259 1.0 0.7864648530623849 0.5736534230216603 20.481582725649375 -6.9711676204821265 0.2285954869899273 1.0880844656598738 0.26596345946129274 0.9999901094554055 0.0005473603175054077 0.07592569666091117 0.007661141198679971 0.005525150698008168 0.02119445313533558 1.0686423459646853e-07 6.9711676204821265 -0.8221210061985811 DGLEMEK(ub)C ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGLEMEKC 8 1 P13693;J3KPG2;P13693-2 P13693 TPT1 Translationally-controlled tumor protein 1 14980800.0 5231700.0 1900100.0 7849000.0 True False 6772538.782224628 1794357.7646778633 6420562.537541018 1.0 0.26494610402045665 0.9480289067362131 22.69126531921517 -10.925954916419162 10.103782839181767 1.070278596785194 0.6064875053783367 0.3067570475336321 0.27886738645397174 0.14182449492228966 0.0010393525959195105 0.0867416934456322 0.09000406196138507 1.1858918477649639e-11 10.925954916419162 -0.46379109140685726 DGLILTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGLILTSR 8 0 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 78701000.0 12443000.0 26738000.0 39520000.0 False True 16312893.498183405 22748794.623907708 35430849.502608486 1.0 1.3945284830334361 2.1719537068365 23.959509366876787 -6.960334221665782 0.43069699185382054 0.9693468016112081 2.626982735070358 0.9997823962898692 0.007182240246313602 0.07958194347407604 0.02069171169742 0.010144278776891185 0.0645399849797931 1.0956346998312984e-07 6.960334221665782 1.6576359334591497 up DGLILTSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGLILTSR 8 0 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 38109800.0 10564000.0 5128800.0 22417000.0 False True 10228651.602441238 7176756.5863386635 16545315.204415264 1.0 0.7016327141913613 1.6175460703409283 23.286112637771083 -6.818980267435916 1.3763143005551477 0.8390156377219167 1.637102336850801 0.8820172931363939 0.1310100957341285 0.19480817646807486 0.7253720582101343 0.07480808581312401 0.17246640506510913 1.5171192975860618e-07 6.818980267435916 0.7980866991288844 DGLILTSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGLILTSR 8 0 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 21194700.0 10564000.0 6229100.0 4401600.0 False True 8784434.064550508 6195542.601920456 5321954.209301041 1.0 0.7052864824750069 0.6058391662108015 23.06651791320536 -13.999999999999998 0.1517109675057707 2.428948396004216 0.49855075748605227 0.999560628547808 0.0035082286920024614 11.964564125985252 0.12275425318276974 5.0376227149872665 0.09686765880197833 1.0000000000000041e-14 13.999999999999998 -1.9303976385181638 DGLITPTIAPNGAQVLQVK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGLITPTIAPNGAQVLQVKR 20 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 1 321556000.0 86341900.0 148816800.0 86397300.0 True False 113195067.03614904 126613913.52334306 77457736.1774219 1.0 1.1185462126446613 0.6842854393353169 26.75423584697228 -6.833950868017069 1.3100399383372752 1.0631931192672894 0.6716176197612528 0.9135668410278979 0.053882300777139173 0.17598739031456206 0.5892609795785312 0.03227859222128192 0.07429170992699514 1.4657136485994802e-07 6.833950868017069 -0.39157549950603665 DGLITPTIAPNGAQVLQVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGLITPTIAPNGAQVLQVKR 20 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 1 575097100.0 148199500.0 167836600.0 259061000.0 True False 143494987.9928048 234854629.63630632 191205152.43658894 1.0 1.6366747920706648 1.3324866262658348 27.096425106284162 -10.055884175737841 4.531067580078809 0.9999752235655147 1.4845807091965426 0.7718799690018086 0.12418429876568922 19285556.706493877 21400401.50315801 3953.300526815852 0.04251159221145167 8.792569791975223e-11 10.055884175737841 0.4846054856310279 DGLITPTIAPNGAQVLQVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGLITPTIAPNGAQVLQVKR 20 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 1 1289104000.0 245235000.0 295906000.0 747963000.0 True False 372039424.08000463 243099262.37586957 600127785.2061707 1.0 0.6534233918274013 1.6130757827351037 28.470880267289882 -6.808996666091785 1.4186217609375313 0.8108938697113327 1.629503212884184 0.8572285560527226 0.1499237889360594 0.20816735323147906 0.8258517589125315 0.08310128405107618 0.192330369893899 1.552398927069366e-07 6.808996666091785 0.8186093431728513 DGLITPTIAPNGAQVLQVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGLITPTIAPNGAQVLQVKR 20 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 1 315956000.0 86341900.0 138231200.0 91382900.0 True False 118264833.73211353 132123688.51454985 69800141.10990249 1.0 1.1171849174863644 0.5902019975609116 26.81744590849517 -6.8483556425144245 1.2429825984593297 1.0624568610179852 0.5697918557138776 0.9378833791429878 0.05630767708311569 0.15927234043867014 0.4743606570033943 0.03546210303164267 0.08198074690686032 1.4178959352006918e-07 6.8483556425144245 -0.4926650053041076 DGLITPTIAPNGAQVLQVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGLITPTIAPNGAQVLQVKR 20 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 1 443128800.0 148199500.0 153982900.0 140946400.0 True False 123234450.6010368 153153363.55448726 170417640.57747802 1.0 1.2427804303709757 1.3828733746636612 26.876830381718438 -11.779505123981522 0.07821767877179707 1.5323079087618957e-15 1.8694057780433468 0.9999375051830358 0.0012503802741237581 5.189682732340261 0.05692345974796697 1.2363934117797788 0.3518682625722583 1.6614790748505325e-12 11.779505123981522 1.8694057780433453 DGLITPTIAPNGAQVLQVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGLITPTIAPNGAQVLQVKR 20 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 1 800094000.0 245235000.0 300079000.0 254780000.0 True False 317461541.80454844 283379339.85935915 208412654.26356214 1.0 0.8926414779205832 0.6564973290272608 28.24200658938233 -6.958143079537222 0.460864222885869 1.0068241010007886 0.5327815658632087 0.9996949883067409 0.002505848393308393 0.08037132372609782 0.02363414439765593 0.0032118403110726005 0.019506049480451714 1.1011764640945981e-07 6.958143079537222 -0.4740425351375799 DGLLENQTPEFFQDVCK(ub)PK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGLLENQTPEFFQDVCKPK 19 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 20895200.0 4029500.0 7314800.0 9550900.0 True False 5282713.521733506 6223460.352867072 8562664.48670201 1.0 1.1780802285157541 1.620883746861253 22.33284774488155 -6.95557719949519 0.4938361119568047 0.9906380829169195 1.8272253966869005 0.9995693828986338 0.005416952232933182 0.08132052259843535 0.027269736692780436 0.006428829215772231 0.03652201663722932 1.1077016445930801e-07 6.95557719949519 0.8365873137699811 DGLLENQTPEFFQDVCK(ub)PK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGLLENQTPEFFQDVCKPK 19 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 10986100.0 4044000.0 2934100.0 4008000.0 True False 3915625.4335736795 4105701.4311293634 2958184.5625773463 1.0 1.0485429469136447 0.7554820073475454 21.900811333507004 -6.86434998028165 1.163486298565 1.0267110601343248 0.7400598509228878 0.9587160972775419 0.026058189784132272 0.14239179215789013 0.36382432436546125 0.01743406261730209 0.040919109158861856 1.3666270724819723e-07 6.86434998028165 -0.28665120921143694 DGLLENQTPEFFQDVCK(ub)PK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGLLENQTPEFFQDVCKPK 19 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 101322000.0 13305000.0 22892000.0 65125000.0 True False 20184657.725791417 18806743.74398762 52253015.20469846 1.0 0.9317345876990951 2.5887491338498623 24.266755787245465 -6.8972920753845415 0.9782420024738543 0.9258958387250407 2.753416270245942 0.9851698326793622 0.09322698594625312 0.11342560532798036 0.18888039561825495 0.07182512372166962 0.18446008323618762 1.2667996205548996e-07 6.8972920753845415 1.8275204315209015 up DGLLENQTPEFFQDVCK(ub)PK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGLLENQTPEFFQDVCKPK 19 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 23957800.0 4029500.0 7047300.0 12881000.0 True False 5519315.043143028 6735926.983695328 9838773.092522284 1.0 1.2204280659905016 1.782607627144889 22.396057806404443 -6.955032634178098 0.5005576048894469 0.988795502448269 2.038510370566086 0.9995393172858733 0.007072143847555124 0.0815256751106511 0.028069864960817842 0.00828512853994638 0.04637560413882931 1.1090914717016844e-07 6.955032634178098 1.049714868117817 DGLLENQTPEFFQDVCK(ub)PK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGLLENQTPEFFQDVCKPK 19 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 72335000.0 13305000.0 12821000.0 46209000.0 True False 17223584.78075933 12107500.07943523 37799436.1443792 1.0 0.7029605180078807 2.194632338478421 24.037882109337914 -6.854946379922219 1.2110080325199268 0.8405466593237938 2.2601967629080097 0.9471991722215428 0.14813641582631218 0.15209525628225729 0.42675703626774675 0.09558472928774926 0.22200214828418433 1.3965407740281356e-07 6.854946379922219 1.419650103584216 up DGLLPENTFIVGYAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGLLPENTFIVGYAR 15 0 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 9184500.0 2057400.0 4236100.0 2891000.0 False True 2697271.323889941 3604090.392188469 2591867.0524301887 1.0 1.3361986835609607 0.9609218877885297 21.363069221762387 -6.6705417988659335 1.9353335554459188 1.2144948069984232 0.9624321680263745 0.28146330868243463 0.1427922352493192 0.4598979770161415 3.3214099262114947 0.05938568294667234 0.15855851700809734 2.1352965635880409e-07 6.6705417988659335 -0.2520626389720486 DGLLPENTFIVGYAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGLLPENTFIVGYAR 15 0 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 8556400.0 2057400.0 3230300.0 3268700.0 False True 2818076.3791444274 3087574.664826392 2496700.38098964 1.0 1.0956320019132288 0.8859590887836909 21.42627928328528 -6.782669003229809 1.5251830350088376 1.0539611571645724 0.8841483659088291 0.7768150340309323 0.04049080537566133 0.24644865876707334 1.1324465706544735 0.020905115413450345 0.04922438567225608 1.6494190143787155e-07 6.782669003229809 -0.16981279125574333 DGLTDVYNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGLTDVYNK 9 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHH9;H0YEL7;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 13487200.0 3690000.0 1069500.0 8727700.0 False True 3572862.969803879 1496556.9273688213 6441653.544612343 1.0 0.4188677091780461 1.8029388753652473 21.76864915255175 -6.792691390952675 1.4859874895921663 0.6763382455528166 1.8186802734920817 0.8097958393564118 0.24748212093855676 0.23136735464172584 1.0092755126954762 0.13108167034504828 0.30624710409907674 1.6117905644431156e-07 6.792691390952675 1.142342027939265 DGLTVHLVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGLTVHLVIK 10 0 Q9NRR5;Q9NRR5-2;C9IYQ4;Q9H347 Q9NRR5 UBQLN4;UBQLN3 Ubiquilin-4;Ubiquilin-3 0 92595000.0 23882000.0 33732000.0 34981000.0 False True 36230740.00806844 27712261.050681055 28066990.017283056 1.0 0.7648825567600784 0.7746733853913182 25.110710937158895 -9.930890771533667 5.359601831370882 1.0000004286936848 0.7697779710768212 0.9986453764845127 0.003997089055138143 1234175.349366001 2286823.419124466 4.113638928201936 0.0013683096826232137 1.1724902189480119e-10 9.930890771533667 -0.23022245761686355 DGLTVHLVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGLTVHLVIK 10 0 Q9NRR5;Q9NRR5-2;C9IYQ4;Q9H347 Q9NRR5 UBQLN4;UBQLN3 Ubiquilin-4;Ubiquilin-3 0 71888000.0 23882000.0 29066000.0 18940000.0 False True 30915719.78459934 27448451.548932515 15493114.340811145 1.0 0.88784772731075 0.5011403405373417 24.881837259251345 -6.94828699838254 0.577344229658147 1.0046699388793363 0.3652780461679001 0.9990599025115978 0.006552035812706439 0.08418099317453799 0.0388660679988349 0.006884707625158722 0.032280810241480586 1.1264528071138859e-07 6.94828699838254 -0.6393918927114361 DGMAFNALIHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGMAFNALIHK 11 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 7180200.0 3787100.0 3393100.0 0.0 False True 4964924.774328565 2886862.7062002085 0.0 1.0 0.5814514494009861 0.0 22.24334042836175 -7.698614106671636 0.6475787619461134 1.0001909721126918 4.870010332143984e-19 0.9874759632888742 0.045889035450318555 0.12015124376310224 0.15105171617705535 0.04278833071333957 0.07784217139645414 2.0016396410518613e-08 7.698614106671636 -1.0001909721126918 down DGMAFNALIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGMAFNALIHK 11 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 9457800.0 3787100.0 2092100.0 3578600.0 False True 5187293.212529335 1999664.1043504628 2733408.383580485 1.0 0.38549278446811036 0.5269431033854493 22.306550489884643 -10.082490646288248 7.6352239186597775 1.0000000537075742 0.45621794392755066 0.9517029293082703 0.05774685088357185 5.2845360727606996e-08 6.3290767491429255e-09 0.05591315377414464 0.0186377159806664 8.270073202259424e-11 10.082490646288248 -0.5437821097800235 DGMDNQGGYGSVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGMDNQGGYGSVGR 14 0 P31942-2;P31942;P31942-3;P31942-4 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 7584970.0 2344200.0 514570.0 4726200.0 False True 2269784.6541502057 720040.4844471012 3488266.4370391783 1.0 0.3172285455056441 1.5368270424513752 21.11412399762146 -6.754780605723319 1.6321061809670527 0.6008469688619859 1.5401721396843648 0.6693159424637589 0.2870000219552281 0.2917706422023534 1.5305014023755668 0.13882923607938072 0.3353719668245701 1.7588118955960831e-07 6.754780605723319 0.939325170822379 DGNASGTTLLEALDCILPPTRPTDK(ub)PLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGNASGTTLLEALDCILPPTRPTDKPLR 28 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 178832000.0 38638000.0 17768000.0 122426000.0 True False 58616670.816169016 14597161.57798237 98228447.43877801 1.0 0.24902747588243856 1.675776636084258 25.804807695470043 -6.7636886401549905 1.5985971700168462 0.5658016514600132 1.6819612107585216 0.7058518179862554 0.3160501870932936 0.27675708505007174 1.394704108875058 0.15593223453762875 0.37337603059654806 1.723103481212349e-07 6.7636886401549905 1.1161595592985085 DGNASGTTLLEALDCILPPTRPTDK(ub)PLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGNASGTTLLEALDCILPPTRPTDKPLR 28 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 191958000.0 38638000.0 28014000.0 125306000.0 True False 50017652.668844715 26454996.27371489 102501593.74813539 1.0 0.5289131908861715 2.049308359726009 25.575934017562492 -6.823502683164581 1.3568158852292738 0.7469524350880685 2.0850142677137846 0.8922141696888408 0.2086345532506521 0.1889717301633938 0.6826278483815104 0.12080875609609544 0.27819611014513523 1.5014031297344964e-07 6.823502683164581 1.338061832625716 up DGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGNASGTTLLEALDCILPPTRPTDKPLR 28 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 320139000.0 89232000.0 185985000.0 44922000.0 False True 116984016.1239172 158236762.963852 40273902.362251505 1.0 1.3526357549243064 0.3442684197094988 26.801736182633597 -6.812212240502419 1.4051662498269404 1.1916800995816765 0.3257076665605093 0.865561426886337 0.15319627762177176 0.20378117395066273 0.7925881031707551 0.08571568624104654 0.1980911890300139 1.5409472052086967e-07 6.812212240502419 -0.8659724330211672 down DGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGNASGTTLLEALDCILPPTRPTDKPLR 28 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 1346850200.0 47347000.0 1271205200.0 28298000.0 False True 71828860.52935341 1044348700.0884391 22704887.896545976 1.0 14.53940230141418 0.31609700793272993 26.098060293450423 -6.657381538789982 1.9830411116730426 9.734024805430115 0.3765577707002544 0.22433761227613724 5.7684201640982256 0.4905762228175919 3.706008567345194 2.352907273037451 6.389490885598826 2.2009919857827383e-07 6.657381538789982 -9.357467034729861 DGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGNASGTTLLEALDCILPPTRPTDKPLR 28 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 300631000.0 89232000.0 65381000.0 146018000.0 False True 122223481.80412927 62492251.23394558 111531555.73510727 1.0 0.5112949681313554 0.91252150641432 26.86494624415649 -10.001576788363405 7.05995710765609 1.0000000257457644 0.7119082372728381 0.40737873064847785 0.1638000483427548 6.639841321581817e-08 9.37293971181945e-09 0.15859872901466707 0.05286623827828815 9.963758936029736e-11 10.001576788363405 -0.28809178847292627 DGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGNASGTTLLEALDCILPPTRPTDKPLR 28 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 120737000.0 47347000.0 41452000.0 31938000.0 False True 61291624.84889987 39145159.76076353 26125611.711553693 1.0 0.6386706153943014 0.42625092377564244 25.869186615542873 -9.423581468515268 0.1297550763248566 1.6239734051263892 8.237473853058122e-09 0.9998766834808078 0.00263013295358564 0.8701430987250798 0.04970729376489171 0.4004908022555403 0.20442543828827528 3.7706700506007835e-10 9.423581468515268 -1.6239733968889154 DGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYK 36 3 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 282481000.0 188547000.0 37325000.0 56609000.0 False True 244077808.31701076 35247830.93868808 46306742.85739062 1.0 0.14441227238859763 0.1897212334734133 27.86276588958707 -10.720805949903085 6.757939018154038 1.0108102025852161 0.16706675293100548 0.9977856494610818 0.01849730590556969 0.0029677270602158586 0.0001226070200233929 0.017642480539602653 0.0059699798101646275 1.9019279035507536e-11 10.720805949903085 -0.8437434496542107 DGNGYISAAELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGNGYISAAELR 12 0 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2 P0DP25 CALM2;CALM1 0 64445000.0 6885000.0 26385000.0 31175000.0 False True 9026301.674434846 22448460.84792445 27949310.051716078 1.0 2.4870053824486194 3.096429862396111 23.105703566015286 -9.519585756763023 0.2592675352152055 6.6299741435376065e-15 3.440500505790911 0.9990194542840859 0.02757183916224574 0.9187971029427104 0.1043669902923767 1.0120516777336301 0.25527406093190347 3.0228336160657416e-10 9.519585756763023 3.4405005057909044 DGNGYISAAELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGNGYISAAELR 12 0 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2 P0DP25 CALM2;CALM1 0 43456200.0 14029000.0 4802200.0 24625000.0 False True 13583657.074086362 6719743.503142162 18174973.765835114 1.0 0.4946932528178633 1.3380029889379081 23.695368607149174 -6.744442736342665 1.6705625449114454 0.7009005603831683 1.3389794927247423 0.6246685657173353 0.21229965412483215 0.3098329346930913 1.6994172608184073 0.10047150757599836 0.2453434384429758 1.8011806124530586e-07 6.744442736342665 0.638078932341574 DGNGYISAAELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGNGYISAAELR 12 0 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2 P0DP25 CALM2;CALM1 0 45940000.0 6885000.0 20047000.0 19008000.0 False True 9430570.560128992 19161257.253436103 14518701.882048227 1.0 2.0318237514119204 1.5395358944061215 23.168913627538178 -10.163724138449412 4.666402058218162 0.999902194952455 1.785679822915714 0.7725301875984494 0.2009756760646667 24509030.987692595 53382287.306150116 15792.838197481688 0.06879932161983526 6.859237832540219e-11 10.163724138449412 0.785777627963259 DGNLASTLGQHK(ub)GPIFALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGNLASTLGQHKGPIFALK 19 1 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 1 12698300.0 6593000.0 2594600.0 3510700.0 True False 9030610.269125694 2479961.9928051755 2681544.965136086 1.0 0.2746173203026815 0.296939507433278 23.106392054537697 -10.122305778030398 5.266685219493047 1.0000170331033265 0.2857784138674257 0.9992679328248438 0.009112994737418015 1.8226485053212737e-06 3.0376218189729656e-07 0.00882382919842998 0.002941206404061957 7.54560769495664e-11 10.122305778030398 -0.7142386192359007 DGNVLLHEMQIQHPTASLIAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 DGNVLLHEMQIQHPTASLIAK 21 0 P40227 P40227 CCT6A T-complex protein 1 subunit zeta 0 137496300.0 35218100.0 63207500.0 39070700.0 False True 46171270.152565524 53777187.38090528 35028038.75661854 1.0 1.1647326834026273 0.758654432526418 25.46049208508923 -6.7965632589289875 1.4697966730916492 1.0912889546604279 0.7535059175140032 0.8219662059411625 0.07036336257274708 0.22569281948642256 0.962873218221635 0.03766724868193537 0.08779400632748423 1.597484823962426e-07 6.7965632589289875 -0.33778303714642466 DGNVLLHEMQIQHPTASLIAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 DGNVLLHEMQIQHPTASLIAK 21 0 P40227 P40227 CCT6A T-complex protein 1 subunit zeta 0 127965600.0 49847000.0 23603200.0 54515400.0 False True 48264634.26986834 33028080.84906197 40236181.31305614 1.0 0.6843122577991114 0.8336576443960673 25.524463110995345 -10.107466371140992 5.048463712851063 1.0000075183150754 0.7589849510969395 0.7764118733550339 0.060969998769128834 5.159543262032512e-06 9.121473404382569e-07 0.059035788641860945 0.019677982487270165 7.807888968654572e-11 10.107466371140992 -0.24102256721813586 DGNVLLHEMQIQHPTASLIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGNVLLHEMQIQHPTASLIAK 21 0 P40227 P40227 CCT6A T-complex protein 1 subunit zeta 0 220263000.0 21579000.0 166380000.0 32304000.0 False True 32736920.636215955 136688189.06712654 25919100.24065384 1.0 4.175352672478063 0.7917391048680447 24.964415286823932 -6.660460705330649 1.9708797640973084 3.043136183889047 0.8057338127887975 0.23767373662302105 1.351840250705287 0.4833837100725819 3.609856310931679 0.5540126911574114 1.499010624595218 2.1854420480181248e-07 6.660460705330649 -2.2374023711002495 DGNVLLHEMQIQHPTASLIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DGNVLLHEMQIQHPTASLIAK 21 0 P40227 P40227 CCT6A T-complex protein 1 subunit zeta 0 148916900.0 35218100.0 48022000.0 65676800.0 False True 48239183.30336654 45900229.25248216 50165292.49615453 1.0 0.9515133986374693 1.0399283126473158 25.52370214661212 -6.757812139174758 1.6206394086161453 0.9717591910310819 1.0402173317953278 0.6819563163567597 0.020387802572238312 0.2866306277087588 1.4832250852575877 0.009928042843425758 0.02391111165263928 1.7465774987719356e-07 6.757812139174758 0.06845814076424594 DGNVLLHEMQIQHPTASLIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGNVLLHEMQIQHPTASLIAK 21 0 P40227 P40227 CCT6A T-complex protein 1 subunit zeta 0 77625000.0 41910000.0 14401000.0 21314000.0 False True 34850021.92780311 14323418.954625325 25770658.8551986 1.0 0.4110017200074758 0.7394732464899526 25.05465622805625 -10.188316996154906 5.607678586007754 1.000011925834717 0.5752374832487178 0.6903684106472322 0.1340979391526195 1.999438422253229e-05 2.894193318884716e-06 0.12984341328998936 0.04327992375822242 6.481611611304535e-11 10.188316996154906 -0.4247744425859993 DGNVLLHEMQIQHPTASLIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGNVLLHEMQIQHPTASLIAK 21 0 P40227 P40227 CCT6A T-complex protein 1 subunit zeta 0 95496000.0 21579000.0 51054000.0 22863000.0 False True 27934440.885682512 48212800.01992711 18702168.594190363 1.0 1.725926794713047 0.6695021629652861 24.73554160891638 -6.721782061173077 1.7528686398678395 1.440803278981529 0.6709785940509283 0.520915803424117 0.3054080033491633 0.3518736354892434 2.1138524904642972 0.1382915073210347 0.3464423573404979 1.8976579701462629e-07 6.721782061173077 -0.7698246849306007 DGPPK(ub)SFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGPPKSFR 8 1 Q9C0C9;K7ES11 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 4470920.0 1541600.0 2048900.0 880420.0 True False 2021052.528875635 1743212.1065496458 789322.5839849837 1.0 0.8625268673840164 0.3905502567140621 20.946675388401317 -6.948385606367795 0.5762939016869796 1.0057235884410112 0.22415693032882897 0.99906843437222 0.00796613010302789 0.08414053990943503 0.03869557182288791 0.00838027424042249 0.03938783835564207 1.1261970713466788e-07 6.948385606367795 -0.7815666581121822 down DGPPK(ub)SFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGPPKSFR 8 1 Q9C0C9;K7ES11 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 4577400.0 1292700.0 2212000.0 1072700.0 True False 1251663.9460882046 3095263.1354276137 791727.6896897999 1.0 2.472918665669939 0.6325401415964464 20.255415840548167 -6.693563254305389 1.8535828249847222 1.9203112418069517 0.6385805113539225 0.38724387259021875 0.6224956198104133 0.40904684165528915 2.7274458222549494 0.26837936879396784 0.6957999840629395 2.0250546393347553e-07 6.693563254305389 -1.2817307304530292 DGPPK(ub)SFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGPPKSFR 8 1 Q9C0C9;K7ES11 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 5581000.0 1292700.0 3081700.0 1206600.0 True False 1074937.3263199967 3065098.2704304396 1458894.4813119392 1.0 2.8514204459935133 1.3571902710890167 20.035821115982444 -6.592805840427517 2.2184834665729234 2.250777175799574 1.3616738481668076 0.0006529640870730491 0.8016848212582671 0.6609671057282582 6.1371709703172925 0.30121664178873525 0.8928469402442625 2.553842791262808e-07 6.592805840427517 -0.8891033276327662 DGPSAGCTIVTALLSLAMGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGPSAGCTIVTALLSLAMGR 20 0 K7EJE8;K7EKE6;P36776-2;P36776;P36776-3;K7ERR6 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 274081000.0 105760000.0 111280000.0 57041000.0 False True 160445652.09167227 91421214.56539156 45766821.34804153 1.0 0.5697955249865986 0.28524812452937137 27.257509453730936 -8.308372971420022 0.22295258601093684 1.250451295616211 1.0151398705267171e-17 0.9996382393047881 0.005588245761579953 0.09844684600938305 0.0508031837917236 0.11250913381578848 0.11269681626850456 4.9161715429599254e-09 8.308372971420022 -1.250451295616211 down DGPSAGCTIVTALLSLAMGRPVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGPSAGCTIVTALLSLAMGRPVR 23 1 K7EJE8;K7EKE6;P36776-2;P36776;P36776-3;K7ERR6 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 3713300000.0 1277700000.0 1098700000.0 1336900000.0 False True 1938364312.3820927 902628400.8177197 1072661129.0159141 1.0 0.46566499138052253 0.5533846873695794 30.852192602382104 -10.790211137120856 7.171350204155367 1.0153513867628468 0.509524839375051 0.9765724990404909 0.03581141592754223 0.008517442606059423 0.00024916682416115744 0.0336003998589069 0.011558084790956512 1.6210218278653523e-11 10.790211137120856 -0.5058265473877958 DGPSAGCTIVTALLSLAMGRPVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGPSAGCTIVTALLSLAMGRPVR 23 1 K7EJE8;K7EKE6;P36776-2;P36776;P36776-3;K7ERR6 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 2608160000.0 1277700000.0 648600000.0 681860000.0 False True 1654007837.2323365 612504839.8347777 557768476.4744185 1.0 0.37031556081359723 0.3372223903169266 30.623318924474553 -13.679929954705026 0.42249079964065434 9.999942372365297 0.3362237796383724 0.9998626017563988 0.0035743595690899076 22.864270480030928 0.21675534249617867 188.28349054110234 0.007981942428534226 2.0896331306829155e-14 13.679929954705026 -9.663718592726925 DGPVRPQNAEEEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGPVRPQNAEEEKR 14 2 Q92504 Q92504 SLC39A7 Zinc transporter SLC39A7 1 8458400.0 2471100.0 2541300.0 3446000.0 True False 3239636.0301664383 2162147.9459098135 3089440.976366119 1.0 0.6674045867426446 0.953638293807776 21.6274003062088 -10.135998369256276 7.142820412252211 1.0000001276883448 0.8105214413224489 0.3687964691278195 0.1168544215824741 2.376934313822711e-07 2.8678605497214274e-08 0.1131438830482775 0.03771460239330188 7.311418288618643e-11 10.135998369256276 -0.18947868636589593 DGPVRPQNAEEEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGPVRPQNAEEEKR 14 2 Q92504 Q92504 SLC39A7 Zinc transporter SLC39A7 1 10867300.0 2318000.0 2341100.0 6208200.0 True False 2244416.35880905 3275913.438675218 4582086.177992184 1.0 1.4595836578260857 2.0415490913742786 21.097908902610463 -6.9679188843980375 0.30381233292471044 0.9035331644202721 2.6159344590659717 0.9999612955845808 0.002651431301859906 0.0769839486493939 0.011434518318693646 0.00947709401888653 0.05198697413379805 1.0766662898175099e-07 6.9679188843980375 1.7124012946456997 DGPVRPQNAEEEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGPVRPQNAEEEKR 14 2 Q92504 Q92504 SLC39A7 Zinc transporter SLC39A7 1 9436300.0 2471100.0 2046700.0 4918500.0 True False 3384732.4489665553 1956270.0264681827 3756851.599687195 1.0 0.577968881134307 1.1099404919979 21.69061036773169 -6.695308675514124 1.8477538300528955 0.7367412216953525 1.1082198808076194 0.39533283574761635 0.1783015681901659 0.4053322076791104 2.6870841970183306 0.07708379151638912 0.1993838743423878 2.016932316169893e-07 6.695308675514124 0.37147865911226685 DGQILPVPNVVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGQILPVPNVVVR 13 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 25661100.0 4714800.0 12249000.0 8697300.0 False True 6181148.458188142 10421496.946228044 7797386.826392628 1.0 1.6860130470451216 1.2614786522500463 22.55944348528544 -10.103364772895382 4.20013422608482 0.9999257241116651 1.4737458493822853 0.62411185700985 0.17331544124751086 22157473.30277963 13324883.674816145 15166.200726638566 0.05933048545772208 7.88197815909978e-11 10.103364772895382 0.4738201252706201 DGQILPVPNVVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGQILPVPNVVVR 13 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 21577600.0 6642000.0 5827000.0 9108600.0 False True 6431153.345646984 8153751.487403572 6722784.407857276 1.0 1.2678521330738526 1.045346619266618 22.6166460591067 -10.167774639655212 4.688033677864435 0.9999803534126094 1.1565993761715172 0.3977521265520704 0.09083749563498407 1.8655266265794837e-05 3.3116989372234704e-06 0.08796405697902876 0.02931767564983454 6.795561705650722e-11 10.167774639655212 0.15661902275890782 DGQILPVPNVVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGQILPVPNVVVR 13 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 35681800.0 4714800.0 13283000.0 17684000.0 False True 6457988.9726791745 12696113.138992973 13507403.413412316 1.0 1.9659546017660412 2.091580439445781 22.62265354680833 -10.887391059427168 0.3821117081676972 3.676480806669187e-16 2.1054273321956094 0.9994220090878271 0.011724287670114386 2.6028061235673317 0.18702509658391184 2.3691559640474242 0.03373531707463825 1.2960117547354282e-11 10.887391059427168 2.105427332195609 DGQILPVPNVVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGQILPVPNVVVR 13 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 11573200.0 6642000.0 2741800.0 2189400.0 False True 5523117.290490771 2727029.379195312 2647193.4173581647 1.0 0.49374822872048674 0.4792933552064656 22.397051334540976 DGQYILATGTYK(ub)PR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGQYILATGTYKPR 14 1 Q9BSC4;Q9BSC4-2 Q9BSC4 NOL10 Nucleolar protein 10 1 973330.0 0.0 973330.0 0.0 True False 0.0 828112.9580106232 0.0 0.0 DGQYILATGTYK(ub)PR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGQYILATGTYKPR 14 1 Q9BSC4;Q9BSC4-2 Q9BSC4 NOL10 Nucleolar protein 10 1 2061500.0 0.0 0.0 2061500.0 True False 0.0 0.0 1521531.306325648 0.0 DGSFGEGLTMK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGSFGEGLTMKK 12 1 G5E9G4;Q9ULT0;Q9ULT0-4 G5E9G4 TTC7A Tetratricopeptide repeat protein 7A 1 7759300.0 1507300.0 2154300.0 4097700.0 True False 2064589.5432508967 2059115.9026825672 3129907.65478057 1.0 0.9973487996264329 1.5159951114797503 20.977423560278353 -6.905749553441635 0.9242013729947159 0.9817040466656827 1.5772662235009711 0.9892159870562023 0.025324919637161696 0.1072964151533878 0.15451345098559505 0.020307567174089002 0.05453651393294025 1.2423685433284184e-07 6.905749553441635 0.5955621768352884 DGSFGEGLTMK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGSFGEGLTMKK 12 1 G5E9G4;Q9ULT0;Q9ULT0-4 G5E9G4 TTC7A Tetratricopeptide repeat protein 7A 1 7802100.0 1600600.0 1970700.0 4230800.0 True False 1330969.818602761 1960083.4479466777 5115440.718991006 1.0 1.47267309938279 3.8433934770670795 20.344046426039185 -6.939735838112263 0.6620154833319807 0.9732651433047401 4.477765831574919 0.998129108294718 0.05380927430023689 0.08788733440504516 0.055159804104447055 0.05227507161436645 0.2042817756250477 1.1488522043728819e-07 6.939735838112263 3.504500688270179 up DGSGVTK(ub)SSWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGSGVTKSSWR 11 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 11672900.0 3717300.0 4659900.0 3295700.0 True False 4873416.298384409 3964661.084147933 2954692.5785867097 1.0 0.8135280963914906 0.6062877451216763 22.216502035433724 -6.969762013320115 0.26380845581102597 1.0555430483014332 0.35809350649676686 0.9999804653489717 0.0007107111434621554 0.07637997240924609 0.009306097115879264 0.004222082628749705 0.01944389001324579 1.0721066422066899e-07 6.969762013320115 -0.6974495418046663 DGSGVTK(ub)SSWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGSGVTKSSWR 11 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 24946100.0 5571800.0 10777000.0 8597300.0 True False 5394926.258849122 15080312.301312543 6345409.216528495 1.0 2.7952768170976943 1.176180898880745 22.36317180953427 -6.621428292649639 2.1117984558488785 2.1899765200487487 1.1824233125127777 0.08770323677111358 0.7717388115637355 0.5814061702165997 4.92917693125471 0.30009487531063134 0.8554507824236949 2.390956679054315e-07 6.621428292649639 -1.007553207535971 DGSGVTK(ub)SSWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGSGVTKSSWR 11 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 21458700.0 6547200.0 3936500.0 10975000.0 True False 9932581.064434556 3234000.818985119 8805786.43948662 1.0 0.3255952101478494 0.8865557081650576 23.24373723219385 -10.305638683402307 8.05793166136436 1.0000010006841 0.6060754591565469 0.39668422621208244 0.22901116433328245 4.116912432766502e-06 3.546966881942787e-07 0.22173966802246012 0.07391303546319776 4.947221059180185e-11 10.305638683402307 -0.3939255415275531 DGSGVTK(ub)SSWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGSGVTKSSWR 11 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 12857200.0 3717300.0 5561800.0 3578100.0 True False 5091686.266255267 5316061.2855869215 2733026.473282658 1.0 1.0440669372774756 0.5367625439523969 22.279712096956615 -6.885748249190554 1.0471835582739113 1.0301004964031464 0.496594329643813 0.978035352294484 0.03400783485999241 0.12266165715315092 0.24253048180382683 0.024871988975150798 0.061130572815487644 1.3009234757808923e-07 6.885748249190554 -0.5335061667593334 DGSGVTK(ub)SSWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGSGVTKSSWR 11 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 23370100.0 5571800.0 13943000.0 3855300.0 True False 4633198.572592062 13867886.291531201 4661425.405106838 1.0 2.993156039882995 1.0060922993203343 22.143577084968545 -6.64551628667757 2.0249560139969844 2.2979637018567796 1.0144952186739309 0.17589455156665523 0.851655038441307 0.5196241059168308 4.078872006472712 0.3417382716087462 0.9429351623083537 2.2619537116101682e-07 6.64551628667757 -1.2834684831828487 DGSGVTK(ub)SSWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGSGVTKSSWR 11 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 17050100.0 6547200.0 4713300.0 5789600.0 True False 8475479.464606361 4451000.711676311 4735952.206312583 1.0 0.5251621138678595 0.5587828070482549 23.0148635542863 -10.054933441158495 5.315167545559545 1.0000043421453837 0.5419724604574186 0.9959752396472755 0.013725590517342663 7.062589984915016e-07 1.2556192388702104e-07 0.013289871782421693 0.004429915290554716 8.81183910611758e-11 10.054933441158495 -0.45803188168796505 DGSLANNPYPGDVTK(ub)FGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGSLANNPYPGDVTKFGR 18 1 Q5T6F2;Q5T6F2-2 Q5T6F2 UBAP2 Ubiquitin-associated protein 2 1 6359200.0 1830200.0 1822500.0 2706500.0 True False 1772101.3028008319 2550233.7542119464 1997586.456740414 1.0 1.4391015627499766 1.127241683973258 20.75702964774926 -10.458601755486104 9.503863258377407 0.9999979763201663 1.2831716233616153 0.5236524392914628 0.12731626237486293 5.465901576794326e-06 3.11380352967943e-07 0.12327432245367975 0.04109114698993485 3.478549954433786e-11 10.458601755486104 0.283173647041449 DGSLANNPYPGDVTK(ub)FGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGSLANNPYPGDVTKFGR 18 1 Q5T6F2;Q5T6F2-2 Q5T6F2 UBAP2 Ubiquitin-associated protein 2 1 8900900.0 1830200.0 2906800.0 4163900.0 True False 1521892.3916073807 2891140.491445378 5034552.238301662 1.0 1.8997009955426842 3.308086870047564 20.537434923183536 -6.9645387168008375 0.3658890135875613 0.8865184482714593 4.369977781738071 0.9999033104460702 0.00934015062954199 0.07811791832976134 0.01541444935749782 0.018687876711919127 0.11988369256296409 1.0850788119244643e-07 6.9645387168008375 3.483459333466612 DGSLANNPYPGDVTK(ub)FGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGSLANNPYPGDVTKFGR 18 1 Q5T6F2;Q5T6F2-2 Q5T6F2 UBAP2 Ubiquitin-associated protein 2 1 18661100.0 2616400.0 4215700.0 11829000.0 True False 3386981.3769544354 3981092.5891018673 9676243.375789601 1.0 1.175410238801388 2.856892996704474 21.691568623635032 -6.926894376648883 0.7718499268869712 0.9712707207688929 3.1762995163060697 0.9958920269564228 0.053650844748582914 0.09428276761105656 0.0858150400319408 0.04800408910639586 0.15482452248785947 1.1833293144124996e-07 6.926894376648883 2.205028795537177 up DGSLASNPYSGDLTK(ub)FGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGSLASNPYSGDLTKFGR 18 1 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;H0Y5H6;H7C2T8 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 1 44425000.0 13425000.0 13746000.0 17254000.0 True False 17600305.00788494 11695150.381488346 15468721.592054842 1.0 0.6644856652341489 0.8788894047645682 24.069097094753097 -10.784534125176616 5.666812380777505 1.013725397144226 0.77168753500068 0.6019006086984319 0.08752996013235308 0.01559275769049871 0.0005928736165594317 0.08706489326645106 0.028250173157233542 1.6423506050612927e-11 10.784534125176616 -0.24203786214354595 DGSLASNPYSGDLTK(ub)FGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGSLASNPYSGDLTKFGR 18 1 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;H0Y5H6;H7C2T8 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 1 103850000.0 20558000.0 24316000.0 58976000.0 True False 19905397.542880267 34025505.606264815 43528416.35792453 1.0 1.709360766745149 2.1867644825558235 24.246656348874392 -8.169226048450428 0.12942009608162877 2.194994065761526e-19 3.3272103865177907 0.9999622481550133 0.0029957453527050927 0.08837242695785814 0.025461867860678538 0.29099941032706556 0.3116381905726039 6.772888898333057e-09 8.169226048450428 3.3272103865177907 DGSLASNPYSGDLTK(ub)FGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGSLASNPYSGDLTKFGR 18 1 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;H0Y5H6;H7C2T8 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 1 499432000.0 65742000.0 139710000.0 293980000.0 True False 99735420.38398956 114777658.94078773 235874724.14398867 1.0 1.1508214283239027 2.36500456142714 26.571602623571152 -6.929978885493343 0.7469665277006716 0.9815220133055066 2.614135385715482 0.9965341177655116 0.03597243489843197 0.09264859331881743 0.07773400727079226 0.032768611882884144 0.10987518741047357 1.1749546774366618e-07 6.929978885493343 1.6326133724099754 up DGSLASNPYSGDLTK(ub)FGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGSLASNPYSGDLTKFGR 18 1 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;H0Y5H6;H7C2T8 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 1 62756000.0 13425000.0 11964000.0 37367000.0 True False 18388585.296983548 11435390.920342691 28541684.197521918 1.0 0.6218744256644119 1.5521413820890222 24.13230715627599 -6.79637727664777 1.470832230262963 0.7903999811451525 1.5638365742939218 0.8212911428358713 0.16148162771699234 0.22598216012983727 0.9655247991632023 0.08638951374998652 0.2013542809792519 1.598169077410537e-07 6.79637727664777 0.7734365931487692 DGSLASNPYSGDLTK(ub)FGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGSLASNPYSGDLTKFGR 18 1 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;H0Y5H6;H7C2T8 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 1 83847000.0 20558000.0 23472000.0 39817000.0 True False 17094887.87381953 23345551.677172773 48142550.60699282 1.0 1.3656452063032252 2.8161957517558305 24.02706162430867 -6.945064380316427 0.6106321626171424 0.9839695687408646 3.2734936099974568 0.9987548106124946 0.027676337274558312 0.0855302748213225 0.04464589592490479 0.02811554780758888 0.1223414241266775 1.1348425728264864e-07 6.945064380316427 2.289524041256592 up DGSLASNPYSGDLTK(ub)FGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGSLASNPYSGDLTKFGR 18 1 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;H0Y5H6;H7C2T8 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 1 457312000.0 65742000.0 108530000.0 283040000.0 True False 85104314.96855928 102490210.09446251 231529624.2356489 1.0 1.204289231777804 2.720539191475598 26.342728945663602 -6.931519475709588 0.7342174677072962 0.9781931836676273 3.044209630933931 0.9968284754109399 0.043220701708855794 0.09185647492941239 0.07387226640609212 0.03973816981593444 0.13606622268384402 1.1707940974921565e-07 6.931519475709588 2.0660164472663034 up DGSLEDDEDEEDDLDEGVGGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGSLEDDEDEEDDLDEGVGGKR 22 1 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 5220300.0 0.0 1718200.0 3502100.0 True False 0.0 2404286.2202946306 2584794.949252026 0.0 DGSLEDDEDEEDDLDEGVGGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGSLEDDEDEEDDLDEGVGGKR 22 1 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 4429800.0 0.0 1467400.0 2962400.0 True False 0.0 1459494.8249439066 3581824.1434099814 0.0 DGSLFWQSPKRPPSPIK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGSLFWQSPKRPPSPIK 17 2 A0AVT1;A0AVT1-2;H0Y8S8 A0AVT1 UBA6 Ubiquitin-like modifier-activating enzyme 6 1 5873400.0 2021000.0 2286900.0 1565500.0 True False 2649550.571391837 1945703.4342663807 1403517.077336377 1.0 0.7343522540293624 0.5297189238396361 21.337316233372693 -7.130997612128623 0.13863935391201687 1.2907790230951541 1.2431510125991636e-11 0.999998467678894 0.0002382562339271649 0.0807027565688981 0.005130737837221872 0.015091470298314553 0.031247041251920255 7.396093416241171e-08 7.130997612128623 -1.2907790230827225 DGSLFWQSPKRPPSPIK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGSLFWQSPKRPPSPIK 17 2 A0AVT1;A0AVT1-2;H0Y8S8 A0AVT1 UBA6 Ubiquitin-like modifier-activating enzyme 6 1 7926500.0 2647300.0 3095200.0 2184000.0 True False 2563262.9105587564 4331129.501254763 1611944.8814044208 1.0 1.689693820877171 0.6288644347657021 21.289550030905872 -6.731254771321853 1.7188998407231113 1.4144767434650134 0.629376725873688 0.5649873543175152 0.28990237586784834 0.33387973739570537 1.933231339933624 0.13362924387277803 0.3310909036610978 1.856714925953e-07 6.731254771321853 -0.7851000175913254 DGSLFWQSPKRPPSPIK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGSLFWQSPKRPPSPIK 17 2 A0AVT1;A0AVT1-2;H0Y8S8 A0AVT1 UBA6 Ubiquitin-like modifier-activating enzyme 6 1 8785000.0 2021000.0 4828200.0 1935800.0 True False 2768218.3154714117 4614874.159277705 1478603.9090524523 1.0 1.667091837910847 0.5341355848953895 21.400526294895585 -6.747142964617742 1.6603476083595867 1.3936020622058416 0.5323579977147207 0.6365982202553424 0.2802867151457707 0.3050636346034134 1.6537117174318934 0.13340381009432145 0.3248548626126138 1.7900165047302622e-07 6.747142964617742 -0.8612440644911209 DGSLFWQSPKRPPSPIK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGSLFWQSPKRPPSPIK 17 2 A0AVT1;A0AVT1-2;H0Y8S8 A0AVT1 UBA6 Ubiquitin-like modifier-activating enzyme 6 1 9093800.0 2647300.0 4899800.0 1546700.0 True False 2201347.24527495 4873403.804865853 1870107.8188672117 1.0 2.213827834443794 0.8495287705659694 21.069955306340148 -6.672020155910332 1.9299903826481346 1.7734516152401012 0.8549771405134824 0.2879798843239503 0.5153733910849229 0.45658447845386363 3.280656430574023 0.21481786307445372 0.5724780815843337 2.1280402798546513e-07 6.672020155910332 -0.9184744747266188 DGSLIVSSSYDGLCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGSLIVSSSYDGLCR 15 0 P61964 P61964 WDR5 WD repeat-containing protein 5 0 7641300.0 2107600.0 3183600.0 2350100.0 False True 2763084.010027435 2708619.2895756024 2106934.1957510198 1.0 0.9802884312405354 0.7625299079234654 21.397847996479076 -6.924622016347283 0.7896840170300959 1.0040526176104119 0.7233877437434801 0.9953716081035077 0.0073202549910834245 0.09552796730240558 0.09207494328604271 0.006466817864435316 0.020317056705676902 1.1895370781705107e-07 6.924622016347283 -0.28066487386693173 DGSLIVSSSYDGLCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGSLIVSSSYDGLCR 15 0 P61964 P61964 WDR5 WD repeat-containing protein 5 0 6127900.0 2107600.0 2073000.0 1947300.0 False True 2886836.675748421 1981408.005505715 1487387.8459023836 1.0 0.6863595790336942 0.515231034161908 21.461058058001967 -12.833213933059556 0.0826390869483792 2.4169562265443134 2.3669442355959866e-19 0.9999032400730175 0.001974568633610824 8.080605938835216 0.07016584241552148 2.350626702007158 0.41816887413485815 1.4682028641110193e-13 12.833213933059556 -2.4169562265443134 DGSLVSLSLTSHTGWVTSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGSLVSLSLTSHTGWVTSVK 20 0 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 0 50566800.0 16763800.0 16991000.0 16812000.0 False True 25431910.19794232 13958823.298711076 13489100.83103864 1.0 0.5488704226330775 0.5304006158424559 24.60013649154039 DGSLVSLSLTSHTGWVTSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGSLVSLSLTSHTGWVTSVK 20 0 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 0 45201800.0 16763800.0 18335000.0 10103000.0 False True 21701069.563900307 17314641.132239673 8264357.66553406 1.0 0.7978704036340472 0.38082720490799243 24.37126281363284 -6.959431512357334 0.4433757479226661 1.0143975840449964 0.14794871850906458 0.9997485224194155 0.004088229889547545 0.07990486044205461 0.021886658060440736 0.005522383497098882 0.03453335139976143 1.0979144162163614e-07 6.959431512357334 -0.8664488655359318 down DGSNHK(ub)AESGALIEAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGSNHKAESGALIEAAK 17 1 E9PCN5;Q9H9A5-4;Q9H9A5-3;Q9H9A5-2;Q9H9A5;Q9H9A5-6;H7C1X9 E9PCN5 CNOT10 CCR4-NOT transcription complex subunit 10 1 13111900.0 1857300.0 3102600.0 8152000.0 True False 2404311.4628563947 2929937.5825954094 6668419.646583547 1.0 1.218618148213857 2.7735257056343534 21.19719236920529 -6.932352364684853 0.7272294548956859 0.9782956645368118 3.1127373230926985 0.996980631110632 0.04338644384992954 0.09143466603033032 0.07183178216041763 0.04009535298278459 0.1389172388761647 1.1685509029039454e-07 6.932352364684853 2.1344416585558865 up DGTACAEVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGTACAEVSR 10 0 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 0 4075000.0 626600.0 1443300.0 2005100.0 False True 821478.6680030309 1227965.2659393346 1797631.4862773335 1.0 1.494823071820538 2.1882874824336898 19.64786358647665 -6.9663620787572675 0.33385034117874074 0.9192185157031081 2.7867249026061196 0.9999385317024233 0.0038210640826184623 0.07750173765277693 0.013246546702922503 0.009984593031669993 0.06030146433634276 1.0805327170067028e-07 6.9663620787572675 1.8675063869030115 DGTAGIPNLQLYDVK(ub)TGTCLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGTAGIPNLQLYDVKTGTCLK 21 1 Q9BY44;Q9BY44-3;F8WAE5;C9IZE1;H7C5Q3 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 1 13623900.0 4082200.0 4309900.0 5231800.0 True False 5351803.732081034 3666879.7198586147 4690463.522969311 1.0 0.6851670770132593 0.8764266699192718 22.351593777989383 -10.32227352269402 5.609697155137228 1.000034594334705 0.7807968744932827 0.6365488916396567 0.07808140183870237 3.3788094632794855e-05 4.082015266279038e-06 0.07561390874212258 0.025200664080817392 4.761310206203303e-11 10.32227352269402 -0.21923771984142237 DGTAGIPNLQLYDVK(ub)TGTCLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGTAGIPNLQLYDVKTGTCLK 21 1 Q9BY44;Q9BY44-3;F8WAE5;C9IZE1;H7C5Q3 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 1 12171000.0 5321000.0 3531700.0 3318300.0 True False 5152087.767568148 4941926.227572197 2449137.683133833 1.0 0.9592084705313261 0.4753680048990815 22.29672573978695 -6.9235641225181235 0.7978642045377192 1.009368190641 0.3905731009159713 0.9951145676447097 0.01665491759851162 0.09612045582013778 0.09508397722840559 0.014627599806061759 0.04542670233106155 1.1924381922749138e-07 6.9235641225181235 -0.6187950897250286 down DGTAGIPNLQLYDVK(ub)TGTCLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGTAGIPNLQLYDVKTGTCLK 21 1 Q9BY44;Q9BY44-3;F8WAE5;C9IZE1;H7C5Q3 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 1 63308700.0 6867700.0 12763000.0 43678000.0 True False 10418802.996123087 10485342.932225863 35045024.155252546 1.0 1.0063865240687953 3.363632479498178 23.3126862018323 -6.907491213141623 0.9126313790286961 0.9210981178583482 3.6524868058938615 0.9899403070003041 0.11160409238933236 0.10610107896158141 0.14793223193406815 0.0902531080705215 0.2450199879206275 1.237396225287745e-07 6.907491213141623 2.7313886880355134 up DGTAGIPNLQLYDVK(ub)TGTCLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGTAGIPNLQLYDVKTGTCLK 21 1 Q9BY44;Q9BY44-3;F8WAE5;C9IZE1;H7C5Q3 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 1 18692900.0 4082200.0 4780300.0 9830400.0 True False 5591499.657306981 4569090.539661824 7508661.983443132 1.0 0.8171493909851051 1.3428708653555579 22.414803839512274 -6.812769356711427 1.4029158862705515 0.9006685210717076 1.3526570343094066 0.8669145435899498 0.07949687288537266 0.2030540090923758 0.7871326461295152 0.04455006687553228 0.10292759960745985 1.5389717339563123e-07 6.812769356711427 0.45198851323769906 DGTAGIPNLQLYDVK(ub)TGTCLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGTAGIPNLQLYDVKTGTCLK 21 1 Q9BY44;Q9BY44-3;F8WAE5;C9IZE1;H7C5Q3 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 1 53683700.0 6867700.0 10017000.0 36799000.0 True False 8890373.032605847 9459545.144349312 30101959.589625668 1.0 1.0640211732011695 3.385905122228883 23.08381252392475 -6.912805787998188 0.8764047611527503 0.9343311027211657 3.7047058560252903 0.9919381285440367 0.09965959479643872 0.10259190061800454 0.1289175107317641 0.08274184939880165 0.23310059748825365 1.2223461585248981e-07 6.912805787998188 2.7703747533041247 up DGTESYLTVSSHPNSLMK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGTESYLTVSSHPNSLMKK 19 1 P53350 P53350 PLK1 Serine/threonine-protein kinase PLK1 1 16363300.0 4385200.0 6702300.0 5275800.0 True False 4245994.226337121 9378563.342032764 3893909.709392601 1.0 2.208802660130638 0.9170784277659625 22.017670978805697 -6.6611111407409656 1.9688377520320217 1.7773866759355996 0.9224497213584091 0.2403246737757997 0.5145463422127446 0.48185698752451117 3.591764875070098 0.211053899276167 0.5705102405593537 2.182171398687227e-07 6.6611111407409656 -0.8549369545771905 DGTESYLTVSSHPNSLMK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGTESYLTVSSHPNSLMKK 19 1 P53350 P53350 PLK1 Serine/threonine-protein kinase PLK1 1 11092200.0 5427900.0 3958200.0 1706100.0 True False 7026523.549904818 3737922.69046256 1395607.3060643042 1.0 0.5319732672799758 0.19861988594391167 22.74437964584331 -8.1419920087162 0.2982848310100901 1.1393444321800688 3.5118727598064067e-16 0.9990728020952718 0.010008839006706627 0.09031174247809494 0.06457948109052183 0.0733397722069201 0.09385365865194473 7.211207481231573e-09 8.1419920087162 -1.1393444321800683 down DGTGVVEFVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGTGVVEFVR 10 0 J3KTL2;Q07955;Q07955-3;Q07955-2;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 30745400.0 3761400.0 14810000.0 12174000.0 False True 4931231.825449409 12600405.728927854 10914351.261253946 1.0 2.5552247744465983 2.2133113282012986 22.233516647262473 -10.339554106088675 5.897333113393043 0.9998236600330455 2.384268051323951 0.9562455083951044 0.1395855799162606 0.0003236692708143602 3.6247973758449634e-05 0.1351695893016269 0.04505105219886382 4.57557727021421e-11 10.339554106088675 1.3844443912909055 DGTGVVEFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGTGVVEFVR 10 0 J3KTL2;Q07955;Q07955-3;Q07955-2;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 15335800.0 4984200.0 2220200.0 8131400.0 False True 4825979.2992131505 3106737.4381900495 6001542.403228898 1.0 0.6437527485243433 1.24359058154423 22.202390296525873 -6.745790912134028 1.6652510051548852 0.7894721122375309 1.2444233714173922 0.6307533986844204 0.14967689166380937 0.307435017981523 1.6759573171372677 0.0710421782246712 0.17325185754648367 1.7955978960934087e-07 6.745790912134028 0.45495125917986134 DGTGVVEFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGTGVVEFVR 10 0 J3KTL2;Q07955;Q07955-3;Q07955-2;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 25813400.0 3761400.0 12004000.0 10048000.0 False True 5152091.228012947 11473623.588080356 7674869.345055798 1.0 2.2269837781008177 1.4896609950006325 22.296726708785364 -10.051068602046326 4.862934494005863 0.9999791522750329 1.8583223865615022 0.643729901309638 0.3010107657578937 208514398.6737483 6.81206162750065 48675.55702435445 0.10304399153032068 8.890606689202958e-11 10.051068602046326 0.8583432342864693 DGTK(ub)MVSADAYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGTKMVSADAYK 12 1 P09543-2;P09543;K7EN66;C9K0L8;K7ERZ0;K7ERC4 P09543-2 CNP 2,3-cyclic-nucleotide 3-phosphodiesterase 1 3136250.0 751450.0 1248600.0 1136200.0 True False 727595.6310729339 1747172.491362983 838595.1347306332 1.0 2.4012960176610063 1.1525565835160612 19.472777354633006 -6.618485902967263 2.122177493811845 1.9307926819617536 1.1572805754091993 0.0776876034311379 0.6028408877562158 0.5895627631785523 5.043215905613376 0.23357580413604578 0.6685936340800915 2.4072106549189755e-07 6.618485902967263 -0.7735121065525543 DGTK(ub)MVSADAYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGTKMVSADAYK 12 1 P09543-2;P09543;K7EN66;C9K0L8;K7ERZ0;K7ERC4 P09543-2 CNP 2,3-cyclic-nucleotide 3-phosphodiesterase 1 2340350.0 784190.0 772080.0 784080.0 True False 1074126.234937916 737966.9526728675 598896.4526344902 1.0 0.6870393149977587 0.5575661716046868 20.034732122998438 -13.999999999893715 0.12117197453541538 2.4904240836825524 0.35414511470408133 0.999687210466225 0.0032847609916537377 11.959408038425403 0.10727981749395868 4.285816804396658 0.1805306991747655 1.0000000002447297e-14 13.999999999893715 -2.136278968978471 DGTK(ub)MVSADAYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGTKMVSADAYK 12 1 P09543-2;P09543;K7EN66;C9K0L8;K7ERZ0;K7ERC4 P09543-2 CNP 2,3-cyclic-nucleotide 3-phosphodiesterase 1 3908200.0 751450.0 2405700.0 751050.0 True False 624863.9698794476 2392740.0166059355 908091.0825371555 1.0 3.8292174488273933 1.4532620319144816 19.253182630067283 -6.603382439616522 2.178436671460385 2.89856894456255 1.461304265777099 0.03025188871277784 1.2218355766424245 0.631152700608766 5.665795973795415 0.46478012465226237 1.357925540396833 2.492398954365474e-07 6.603382439616522 -1.437264678785451 DGTLFAWGNGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGTLFAWGNGEK 12 0 Q9BY44;Q9BY44-4;C9IZE1;H7C5Q3 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 4489440.0 901940.0 1367800.0 2219700.0 False True 1182452.0743993856 1163729.5716426405 1990026.7368658944 1.0 0.9841663749744318 1.682966083743147 20.17335028064571 -6.901719875478768 0.9503649925990924 0.9723008869541871 1.7589244705235239 0.9874015256315893 0.03656307221311318 0.11014986536870479 0.17038126295286016 0.028759555827389684 0.07549135717699534 1.2539497249494562e-07 6.901719875478768 0.7866235835693367 DGTTHQTSLELFMYLNEVAGK ddPTM_RPMI8226_Bortezomib_8h_R1 2 DGTTHQTSLELFMYLNEVAGK 21 0 P00966 P00966 ASS1 Argininosuccinate synthase 0 125526000.0 24490900.0 64015100.0 37020000.0 False True 37154485.82462126 52591105.25274081 29702980.773557603 1.0 1.4154712166112153 0.7994453459472787 25.147033068413972 -6.725017059260523 1.7412582431356127 1.2514025685877455 0.800122662585748 0.5360931979013849 0.17473288630105901 0.3456538860295218 2.0507121898636034 0.07959763775222167 0.19865077517718197 1.8835751004552005e-07 6.725017059260523 -0.4512799060019974 DGTTHQTSLELFMYLNEVAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGTTHQTSLELFMYLNEVAGK 21 0 P00966 P00966 ASS1 Argininosuccinate synthase 0 56983000.0 20529000.0 14423000.0 22031000.0 False True 26575195.18708821 13620347.37116404 18021584.05714947 1.0 0.5125210661775912 0.6781355294016961 24.663576952182783 -10.214477865848806 5.548015651731101 1.0000177424561745 0.5953282977896195 0.8884008053859445 0.06761182148741667 1.4838625765345558e-05 2.1009020781565395e-06 0.06546773172418369 0.02182162155228035 6.102701587385491e-11 10.214477865848806 -0.404689444666555 DGVCVLGLHLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGVCVLGLHLAK 12 0 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 0 9744100.0 2228400.0 2798200.0 4717500.0 False True 2921453.9798562997 2380719.4672981687 4229378.353455349 1.0 0.814909111597668 1.4476963808491632 21.478255132762175 -6.828422366705823 1.335090429858397 0.9009888850353798 1.4641645578856903 0.9026536512491412 0.08288256728417516 0.18276754678512988 0.6377122075485826 0.04875246697567637 0.11219414582638736 1.484491219939869e-07 6.828422366705823 0.5631756728503106 DGVCVLGLHLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGVCVLGLHLAK 12 0 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 0 17391700.0 2228400.0 5375900.0 9787400.0 False True 3052299.7002456733 5138374.962276017 7475817.697830333 1.0 1.683443785635611 2.4492410418376087 21.541465194285067 -6.969651674297791 0.26637238829601173 0.8010589508513618 3.354537207260661 0.9999795376920554 0.002677780058195766 0.07641586909028203 0.009433729382700866 0.015351922262915634 0.0715854128199623 1.0723790615725009e-07 6.969651674297791 2.5534782564092993 DGVGMVEYLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGVGMVEYLR 10 0 Q13242;H0YIB4 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 0 17958500.0 2844400.0 6752300.0 8361800.0 False True 3729035.9452087875 5744883.160259256 7496601.148049394 1.0 1.540581331118706 2.0103322301522253 21.830371273039248 -6.97276865648332 0.1801665857210825 0.6376584119165289 2.9259602293031755 0.9999967020044301 0.0007496459430526804 0.07541411130003085 0.005682918566348247 0.01806285979807434 0.0526897020202307 1.0647100255874389e-07 6.97276865648332 2.2883018173866465 DGVGMVEYLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGVGMVEYLR 10 0 Q13242;H0YIB4 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 0 10375700.0 3275800.0 1065300.0 6034600.0 False True 3171811.52208226 1490679.8454661097 4453957.22588055 1.0 0.46997743563510813 1.4042313658525887 21.596875613936025 -6.752816962052068 1.6395856811219636 0.6893992663699199 1.4064763559413118 0.660950073649766 0.22275599326470177 0.29515010053896595 1.561933741524358 0.10729056179437127 0.2596898127350001 1.766782292653148e-07 6.752816962052068 0.7170770895713919 DGVGMVEYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGVGMVEYLR 10 0 Q13242;H0YIB4 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 0 12946800.0 2844400.0 4821700.0 5280700.0 False True 3896051.5470197434 4608661.350770341 4033507.4194303527 1.0 1.1829056405312972 1.0352808146277621 21.89358133456214 -10.024267765340781 4.704138378932145 0.999997195741495 1.10909322758343 0.42134353040987516 0.06026758281851873 1.7726074888010042e-06 3.674922125055366e-07 0.05835533607829343 0.0194512787124642 9.456539363081989e-11 10.024267765340781 0.10909603184193495 DGVIEASINHEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGVIEASINHEK 12 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 15552700.0 4976000.0 4565500.0 6011200.0 False True 6523584.18765255 3884345.1961796163 5389218.687502031 1.0 0.5954311440529384 0.8261131507588148 22.637233397123563 -10.17732335875246 5.412461175179838 1.0000101984631886 0.7107721474058214 0.6770027055910497 0.09417553487864126 1.1589991831258537e-05 1.7616967216210124e-06 0.0911882829652126 0.03039502318373472 6.64778004084974e-11 10.17732335875246 -0.2892380510573672 DGVIEASINHEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGVIEASINHEK 12 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 11823600.0 2927000.0 1589900.0 7306700.0 False True 2834083.9871587977 2224755.361218972 5392856.073698567 1.0 0.784999799335275 1.9028568306844598 21.434451082012743 -6.856873660521043 1.2014997479922975 0.8841905402005165 1.953825165241043 0.9497151278428625 0.10860241115881034 0.15006066227160422 0.41343765249738723 0.07058437658276535 0.16422054756082985 1.3903570375402212e-07 6.856873660521043 1.0696346250405266 DGVIEASINHEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGVIEASINHEK 12 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 14583200.0 4976000.0 4235600.0 5371600.0 False True 6815761.671343773 4048457.1867438573 4102938.711574616 1.0 0.5939845584339039 0.6019780193936409 22.700443458646454 -10.06925644934675 4.9963499806584055 1.000008993438009 0.5979812889116023 0.9997035775764282 0.0032633167792263215 3.269272765076131e-07 6.090678986801927e-08 0.0031597635193617263 0.001053230960535517 8.525965101375794e-11 10.06925644934675 -0.4020277045264067 DGVIEASINHEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGVIEASINHEK 12 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 7291300.0 2927000.0 2897700.0 1466600.0 False True 2433930.1880858922 2882089.51495158 1773259.2792077656 1.0 1.184129901941901 0.7285579873604773 21.21485635744702 -6.796994064823825 1.4680741274956455 1.1019868893491374 0.7227219895297626 0.8232183777980894 0.07867602723775562 0.22509717748060418 0.9580528567736502 0.04216534728937881 0.09824953945629453 1.59590095706626e-07 6.796994064823825 -0.3792648998193747 DGVIEASINHEK(ub)GYVQSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGVIEASINHEKGYVQSK 18 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 125716000.0 11546000.0 42394000.0 71776000.0 True False 17516126.125666123 34828459.4741662 57589442.1394616 1.0 1.9883654196308034 3.2877955848397686 24.062180407343668 -6.967355462650861 0.31501913302189316 0.8113147290140793 4.506453717806281 0.9999537907631231 0.006368539426388847 0.07717050983469644 0.012087427353106741 0.020110175744472655 0.11481733409663321 1.0780639839811162e-07 6.967355462650861 3.6951389887922015 DGVIEASINHEK(ub)GYVQSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGVIEASINHEKGYVQSK 18 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 94428000.0 11546000.0 36037000.0 46845000.0 True False 14946524.605685627 34031509.27093103 38319690.67029032 1.0 2.2768844376026727 2.563786009204681 23.833306729436117 -10.349436243058387 0.3260578051803739 4.138263215847905e-18 2.635707139068501 0.9990273441604968 0.021198718541176866 1.824226883032666 0.1536142584322824 1.6580630468340218 0.092563670263611 4.472638078829587e-11 10.349436243058387 2.635707139068501 DGVIEASINHEKGYVQSKEMIDIYSTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGVIEASINHEKGYVQSKEMIDIYSTR 27 2 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 36954500.0 6830500.0 14745000.0 15379000.0 False True 10362367.876438804 12113639.54678918 12339333.909144837 1.0 1.1690030397716618 1.190783231813369 23.304850371218766 -13.38378189841615 0.2965469272576039 2.4613202643554433e-13 1.1964449991197401 0.999609950898186 0.0016839907931480685 11.423923896001567 0.1710298817861238 6.904000938681516 0.007993825197911582 4.132549854892396e-14 13.38378189841615 1.196444999119494 DGVLK(ub)LADFGLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGVLKLADFGLAR 13 1 P50750;P50750-2 P50750 CDK9 Cyclin-dependent kinase 9 1 11868400.0 772700.0 1806900.0 9288800.0 True False 748171.0614545953 2528404.592859021 6855784.621973168 1.0 3.3794471921211344 9.16339187009471 19.513008639332032 -6.956060827443409 0.487796720692899 0.8708584177887004 11.916329494664364 0.9995950382529784 0.06898263764605639 0.0811395443783681 0.026568442487862026 0.08288480146709129 0.47704628815601996 1.106468800700947e-07 6.956060827443409 11.045471076875664 DGVLK(ub)LADFGLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGVLKLADFGLAR 13 1 P50750;P50750-2 P50750 CDK9 Cyclin-dependent kinase 9 1 20250300.0 772700.0 1137100.0 18340500.0 True False 642534.2864140645 1130974.2166033217 22175413.753109217 1.0 1.7601772240283142 34.512420927556306 19.293413914766308 -6.911900407632344 0.8827031761869515 0.04586587002329813 38.92163486625148 0.9916190129485736 1.430141638699428 0.10317435054441444 0.13205320033908216 1.1819923529674874 3.307395983773401 1.2248970603330848e-07 6.911900407632344 38.87576899622818 up DGVNCLAK(ub)HPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGVNCLAKHPEK 12 1 A0A087WT20;Q9NV06;E5RHM4;B3KME9;Q9NV06-2 A0A087WT20 DCAF13 DDB1- and CUL4-associated factor 13 1 29769600.0 2699300.0 3230300.0 23840000.0 True False 3494297.061157737 3050530.9653380862 19501364.619056933 1.0 0.8730027561902189 5.580912062638345 21.73657083082487 -6.900703428452404 0.9568400766724091 0.8080225388984781 6.082154395987177 0.9869121925543907 0.25054142516256445 0.11088835246168785 0.17452683774088007 0.19612644030218376 0.5120951080493975 1.256887975901362e-07 6.900703428452404 5.274131857088699 up DGVPIGYK(ub)GSTFHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGVPIGYKGSTFHR 14 1 C9JQD4;O43447;O43447-2;C9JAN8 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 1 9831000.0 1933900.0 2171500.0 5725600.0 True False 1872509.403063341 3038591.274222904 4225893.595681844 1.0 1.62273752497686 2.2568076767830765 20.836541532717835 -6.970900380177791 0.2356921622956762 0.7598063863996017 3.1379814347635246 0.9999885783363542 0.0017340489814876158 0.07601161853552037 0.00797728485550554 0.0156302032883377 0.06230032468768382 1.0693001304908987e-07 6.970900380177791 2.378175048363923 DGVPIGYK(ub)GSTFHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGVPIGYKGSTFHR 14 1 C9JQD4;O43447;O43447-2;C9JAN8 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 1 26453000.0 1964000.0 5900000.0 18589000.0 True False 2979531.5876327963 4847098.9030896025 14914876.002151858 1.0 1.6267989650482502 5.005778782161379 21.506654111650576 -6.93814099250728 0.6766356058800483 0.9605759263921093 5.869224434299888 0.9979101520424597 0.08042674567094331 0.08862502201179923 0.058548752916775235 0.07722782724224372 0.2932837516842299 1.1530788531761505e-07 6.93814099250728 4.908648507907778 DGVPIGYK(ub)GSTFHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGVPIGYKGSTFHR 14 1 C9JQD4;O43447;O43447-2;C9JAN8 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 1 6704300.0 1933900.0 2600500.0 2169900.0 True False 1608123.5362963127 2586490.5903411624 2623616.057515977 1.0 1.6083904824240915 1.6314766859009207 20.61694680815211 -11.374085708728447 0.5370838228318477 2.6569941247709707e-17 1.629682363291534 0.9998942285199467 0.0030071018357604074 3.893686891739646 0.26417817512348873 4.594833404013467 0.004402550916848985 4.22585208151643e-12 11.374085708728447 1.629682363291534 DGVTAK(ub)DVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGVTAKDVTR 10 1 Q5VXN5;A0A5F9ZHD5;P17707-2;P17707 Q5VXN5 AMD1 S-adenosylmethionine decarboxylase proenzyme;S-adenosylmethionine decarboxylase alpha chain;S-adenosylmethionine decarboxylase beta chain 1 7716900.0 3054200.0 3590800.0 1071900.0 True False 4004085.7769148727 3055066.636828776 960990.0703908411 1.0 0.7629873102225819 0.24000236856346244 21.933041449742884 -7.018938726505225 0.48014834647844545 1.0125122965157731 2.1525790300741043e-11 0.9996655369861299 0.005806632828982748 0.07418563934610399 0.02489918160955034 0.007265834129297259 0.03958162575690582 9.573291288790364e-08 7.018938726505225 -1.0125122964942472 down DGVTAK(ub)DVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGVTAKDVTR 10 1 Q5VXN5;A0A5F9ZHD5;P17707-2;P17707 Q5VXN5 AMD1 S-adenosylmethionine decarboxylase proenzyme;S-adenosylmethionine decarboxylase alpha chain;S-adenosylmethionine decarboxylase beta chain 1 10975200.0 4287700.0 5278200.0 1409300.0 True False 4151589.3104683245 7385812.785449375 1040162.0519062503 1.0 1.7790326145281001 0.2505455077850448 21.985232303709807 -6.768097293852862 1.5814343342966108 1.4478801867465623 0.2424712100564146 0.7234552415992823 0.3281678059504591 0.269452190365634 1.3295886002300508 0.16358813909041048 0.39013928855106733 1.705700222653032e-07 6.768097293852862 -1.2054089766901477 DGVTAK(ub)DVTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGVTAKDVTR 10 1 Q5VXN5;A0A5F9ZHD5;P17707-2;P17707 Q5VXN5 AMD1 S-adenosylmethionine decarboxylase proenzyme;S-adenosylmethionine decarboxylase alpha chain;S-adenosylmethionine decarboxylase beta chain 1 18777600.0 9364100.0 3687900.0 5725600.0 True False 14206024.307409517 3029765.431305781 4593932.650380369 1.0 0.21327328221770878 0.32337919117766717 23.759999523190075 -10.784526179602912 7.238926742771832 1.0201612883640463 0.2683262366976881 0.983299352389908 0.04495054910287275 0.013503428748374473 0.0004019424361436976 0.040182352610909446 0.014507727339858742 1.6423806527310143e-11 10.784526179602912 -0.7518350516663581 DGVTAK(ub)DVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGVTAKDVTR 10 1 Q5VXN5;A0A5F9ZHD5;P17707-2;P17707 Q5VXN5 AMD1 S-adenosylmethionine decarboxylase proenzyme;S-adenosylmethionine decarboxylase alpha chain;S-adenosylmethionine decarboxylase beta chain 1 7274900.0 3054200.0 2767600.0 1453100.0 True False 4183420.2766515557 2645318.28077068 1109907.7075338964 1.0 0.6323338574263484 0.2653110694444202 21.996251511265775 -7.493885724046759 0.31331534993044724 1.078824215101874 2.1635181179365966e-11 0.9996467937838525 0.005636919959157328 0.12270741394312779 0.03288495023868891 0.02165207983289814 0.06470682703339856 3.2071131015007315e-08 7.493885724046759 -1.078824215080239 down DGVTAK(ub)DVTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGVTAKDVTR 10 1 Q5VXN5;A0A5F9ZHD5;P17707-2;P17707 Q5VXN5 AMD1 S-adenosylmethionine decarboxylase proenzyme;S-adenosylmethionine decarboxylase alpha chain;S-adenosylmethionine decarboxylase beta chain 1 12568200.0 4287700.0 7349200.0 931300.0 True False 3565412.5273166685 7309608.400898009 1126030.5241553204 1.0 2.0501438038080897 0.315820544054343 21.765637579144084 -6.7428020210007436 1.6765476095999812 1.6228104090043458 0.3142009319215449 0.6173676282422382 0.4412091619233982 0.31279181723163596 1.727365759225326 0.2081054070103814 0.509087980324849 1.8079981385237512e-07 6.7428020210007436 -1.308609477082801 DGVTAK(ub)DVTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGVTAKDVTR 10 1 Q5VXN5;A0A5F9ZHD5;P17707-2;P17707 Q5VXN5 AMD1 S-adenosylmethionine decarboxylase proenzyme;S-adenosylmethionine decarboxylase alpha chain;S-adenosylmethionine decarboxylase beta chain 1 22738300.0 9364100.0 5359100.0 8015100.0 True False 12122012.04400666 5060861.373972489 6556434.041870938 1.0 0.4174935114401795 0.5408701144718426 23.531125845282524 -9.796460461133934 6.390669679737105 1.000000010598946 0.479181812956222 0.959612185100123 0.05036828727161826 7.566480893782776e-09 1.4782910197650206e-09 0.04876888589810624 0.016256294814893813 1.597862994446181e-10 9.796460461133934 -0.520818197642724 DGVTLYLLQSVNQLLLTATK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGVTLYLLQSVNQLLLTATK 20 0 A6NHR9-2;A6NHR9 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 0 197230000.0 74952000.0 70871000.0 51407000.0 False True 113707663.72518006 58223516.33234965 41246383.91751147 1.0 0.5120456653921763 0.36274058024092215 26.760754252077614 -13.999999999999998 0.1658780026981198 3.4353518395034928 0.2250860003674698 0.9995221544986734 0.005948664000873602 12.054067322587569 0.1288812122238979 9.443525728214809 0.12645129458065413 1.0000000000000041e-14 13.999999999999998 -3.210265839136023 DGVVEITGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGVVEITGK 9 0 P04792 P04792 HSPB1 Heat shock protein beta-1 0 33205100.0 5339100.0 15642000.0 12224000.0 False True 6999611.803917957 13308274.572038464 10959177.740887804 1.0 1.9012875206292588 1.565683647592217 22.738843482225747 -10.361985972712738 5.582331054813683 0.9997987267475041 1.7334855841107435 0.8642954919612241 0.13700970744044325 0.0003432977934153502 3.923605295595674e-05 0.13269458199593306 0.0442196929321294 4.34524258653747e-11 10.361985972712738 0.7336868573632394 DGVVEITGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGVVEITGK 9 0 P04792 P04792 HSPB1 Heat shock protein beta-1 0 70275600.0 1964400.0 65035000.0 3276200.0 False True 2980138.416876714 53428996.12922569 2628657.6339905267 1.0 17.928360584412413 0.8820589067622734 21.50694790964383 -6.527616483340827 2.4844764245327347 9.999999999999998 0.8819890926868156 0.2511370179341056 6.929915314247788 0.5674453248279304 6.54589655034899 2.6687194298814796 8.67337374828359 2.967450728436191e-07 6.527616483340827 -9.118010907313183 DGVVEITGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGVVEITGK 9 0 P04792 P04792 HSPB1 Heat shock protein beta-1 0 30242100.0 5339100.0 11776000.0 13127000.0 False True 7313109.553752324 11255697.38197555 10026672.959051313 1.0 1.5391123706331327 1.371054663594732 22.802053543748638 -10.086313641815575 4.592933729764072 0.9999712590490722 1.4550835171073264 0.9072095005031392 0.06860927164641789 47693265.89188645 0.04166168761944647 14600.02825914056 0.023486778576928196 8.197593110117682e-11 10.086313641815575 0.45511225805825417 DGVVEITGK(ub)HEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGVVEITGKHEER 13 1 P04792 P04792 HSPB1 Heat shock protein beta-1 1 48504000.0 14975000.0 17469000.0 16060000.0 True False 19632370.018106293 14862693.293628687 14398265.258398078 1.0 0.7570503856600762 0.7333941467647069 24.22673100955647 -13.999999999999998 0.329348466371966 3.634312273672626 0.7291726187999388 0.9997134860034556 0.0020395104272652818 18.768222930134574 0.18347839707062194 34.23574326141351 0.00759912549058057 1.0000000000000041e-14 13.999999999999998 -2.905139654872687 DGVVEITGK(ub)HEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGVVEITGKHEER 13 1 P04792 P04792 HSPB1 Heat shock protein beta-1 1 83686000.0 20758000.0 28323000.0 34605000.0 True False 20099048.65235474 39632521.60249374 25540912.37225273 1.0 1.971860573502842 1.270752303455937 24.260623880192266 -10.082361469831108 4.480879618230394 0.9999575737406532 1.6213064380078543 0.5114995362984553 0.2862262528134092 99445129.81705579 5.000326059341795 49276.20375748734 0.0979828594895088 8.272533416915852e-11 10.082361469831108 0.6213488642672012 DGVVEITGK(ub)HEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGVVEITGKHEER 13 1 P04792 P04792 HSPB1 Heat shock protein beta-1 1 198511000.0 40869000.0 68490000.0 89152000.0 True False 62001260.92411652 56267424.385187514 71531068.1232903 1.0 0.9075206462986831 1.1537034417870522 25.88579422020253 -6.804981579127646 1.4357983867659645 0.9492925884693745 1.1575220796370043 0.8462365974399482 0.03981436400835771 0.21373204539989635 0.8693303951403437 0.021811259845986912 0.050571876017095126 1.566817526245082e-07 6.804981579127646 0.2082294911676298 DGVVEITGK(ub)HEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGVVEITGKHEER 13 1 P04792 P04792 HSPB1 Heat shock protein beta-1 1 48119000.0 14975000.0 18884000.0 14260000.0 True False 20511662.18415856 18049642.438962817 10892081.693918752 1.0 0.8799697594913983 0.5310189684349841 24.28994107107936 -6.952155072522599 0.5346627165077896 1.0053256966632147 0.3896951502036792 0.99935972522562 0.005033361033152463 0.08263176951467653 0.03246918116038594 0.005577623509301429 0.028874713234086562 1.1164645232031278e-07 6.952155072522599 -0.6156305464595355 DGVVEITGK(ub)HEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGVVEITGKHEER 13 1 P04792 P04792 HSPB1 Heat shock protein beta-1 1 67277000.0 20758000.0 32711000.0 13808000.0 True False 17261196.735321812 32534779.350374848 16695188.959021427 1.0 1.8848507348159993 0.9672092390244208 24.041029155626543 -6.654427238707665 1.992521405362449 1.5721481370711694 0.9710450625917618 0.2122974001499297 0.37725393020150305 0.49776259136978257 3.792727107553494 0.15327997315439842 0.4180332854717066 2.2160153343553002e-07 6.654427238707665 -0.6011030744794076 DGVVEITGK(ub)HEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGVVEITGKHEER 13 1 P04792 P04792 HSPB1 Heat shock protein beta-1 1 197927000.0 40869000.0 54698000.0 102360000.0 True False 52905726.148429446 51654008.21659368 83731530.302293 1.0 0.9763405963217665 1.5826553456119352 25.65692054229498 -6.897820980619069 0.9749589921678833 0.973261482787001 1.6435512221228186 0.9854497144978085 0.03382425426965831 0.11302736252805318 0.18661343144510364 0.026123187853748522 0.06725332134900722 1.2652577885629125e-07 6.897820980619069 0.6702897393358176 DGVWNLQNEVTK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGVWNLQNEVTKER 14 1 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 17047200.0 5429000.0 6768100.0 4850100.0 True False 7117471.574510784 5758325.861847169 4348258.177444365 1.0 0.8090409356138475 0.6109273682267203 22.762933395522243 -6.970663652935344 0.24182366073541128 1.069547450609082 0.34467784321857586 0.999987101460731 0.0005704630976390145 0.0760880421848434 0.008256444555478812 0.004675153685820518 0.019251898579205305 1.0698831484283467e-07 6.970663652935344 -0.7248696073905062 DGVWNLQNEVTK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGVWNLQNEVTKER 14 1 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 35345900.0 8237900.0 14006000.0 13102000.0 True False 12497496.57116101 11506519.87062253 10512383.957189409 1.0 0.9207059834026889 0.8411591791469334 23.575135795412233 -6.971086433938739 0.2307843938654205 1.0320355659239213 0.7275546125030528 0.999989649258612 0.0002085480096556219 0.07595184799055787 0.007757868776244705 0.002032160071810728 0.007888587591621964 1.0688421354892126e-07 6.971086433938739 -0.30448095342086856 DGVWNLQNEVTK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGVWNLQNEVTKER 14 1 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 14639600.0 5429000.0 5074300.0 4136300.0 True False 7436248.013208463 4850100.647533836 3159391.129772521 1.0 0.6522241645140072 0.4248636038175066 22.826143457045134 -8.415660240874763 0.14953782847748776 1.4103771290098284 4.35431932588058e-12 0.9999109331866816 0.0022320383904105077 0.12018092138527722 0.034964426423310914 0.15410795019924448 0.14151764075829995 3.840075464444042e-09 8.415660240874763 -1.410377129005474 down DGVWNLQNEVTK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGVWNLQNEVTKER 14 1 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 30457900.0 8237900.0 11010000.0 11210000.0 True False 10664123.943285786 10397283.821432164 9169895.024313245 1.0 0.9749777737700033 0.8598826376250701 23.346262117504683 -6.941686097038232 0.6437231271686737 1.001263737442392 0.8272465346589006 0.9983760634663483 0.0024587964287683304 0.08700664405092481 0.051176847302289476 0.0024251465881509116 0.009834814628266571 1.1437046924609399e-07 6.941686097038232 -0.17401720278349142 DGVYFLYEALHGPPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGVYFLYEALHGPPK 15 0 P30520 P30520 ADSS Adenylosuccinate synthetase isozyme 2 0 9312100.0 1140600.0 3325000.0 4846500.0 False True 1495337.645586111 2828922.960748491 4345030.67091073 1.0 1.8918288916879835 2.905718774442849 20.512039849475304 -6.969454401647385 0.27089930405184665 0.7506861216099403 4.077378864457986 0.9999778093983018 0.0036674476710028387 0.07648011869563551 0.009661859422210794 0.019765699924148547 0.09418117870980314 1.0728662865384507e-07 6.969454401647385 3.3266927428480453 DGVYVLDLAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGVYVLDLAAK 11 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 27447600.0 7496600.0 8298000.0 11653000.0 False True 9828115.197177658 7059970.745350664 10447259.343469055 1.0 0.7183443217452393 1.0629972414720166 23.228483337221945 -6.68945034401457 1.8681979929320127 0.8233295877855711 1.0618034631754156 0.36790812385405225 0.11913381199521615 0.41786387293725497 2.827135002124616 0.051020771396350056 0.1329621280482636 2.0443236647445483e-07 6.68945034401457 0.23847387538984455 DGVYVLDLAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGVYVLDLAAK 11 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 22236500.0 5801000.0 4332500.0 12103000.0 False True 5616850.430306854 6062489.843689035 8932861.217782829 1.0 1.0793397329894425 1.5903683618819129 22.421329955589894 -6.934352732838554 0.7101523725438803 0.9933411701597238 1.7079424799073997 0.9973267573923872 0.013526366416612748 0.0904396994248881 0.06706353973254837 0.012659487453588643 0.04518381133858883 1.163180913166651e-07 6.934352732838554 0.7146013097476759 DGVYVLDLAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGVYVLDLAAK 11 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 29864600.0 7496600.0 10509000.0 11859000.0 False True 10268295.607997518 10044677.631384265 9058148.443771565 1.0 0.97822248354059 0.8821472218540901 23.291693398744837 -6.942634640583933 0.6346139084302487 1.0010488717044044 0.8541021078711923 0.9984886252913145 0.001990507066262768 0.08658579817359567 0.049295287286754245 0.0019786774765593487 0.008177903015315348 1.1412094504172948e-07 6.942634640583933 -0.14694676383321204 DGVYVLDLAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGVYVLDLAAK 11 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 12530000.0 5801000.0 3257400.0 3471600.0 False True 4823788.527873673 3239851.7396567273 4197495.509135193 1.0 0.6716405001868635 0.8701657389996428 22.20173523102417 -10.311784105497455 5.616015505034148 1.000031259837228 0.7709031210099124 0.6397178011203525 0.08104758935925704 3.172615998440622e-05 3.887859140776873e-06 0.07848468575105645 0.026157996986553585 4.877709083045021e-11 10.311784105497455 -0.22912813882731564 DGWPAMGIHGDK(ub)SQQER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGWPAMGIHGDKSQQER 17 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 28768000.0 2570600.0 6751400.0 19446000.0 True False 3899788.136033029 5546559.921071038 15602489.576515427 1.0 1.4222721152008915 4.0008556958139545 21.894964318069057 -6.935464795842328 0.7004929753653554 0.9675777707612865 4.6122845993093415 0.997507327973718 0.06621961279716872 0.08989812785612147 0.06449824140757102 0.06242753546100794 0.2267191558973735 1.1602062593155578e-07 6.935464795842328 3.6447068285480553 up DGWPAMGIHGDK(ub)SQQER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGWPAMGIHGDKSQQER 17 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 48851000.0 2570600.0 3217400.0 43063000.0 True False 3327692.3741014623 3038348.8616780937 35225975.86369325 1.0 0.9130498015155332 10.585706821293813 21.666090640161507 -6.904871972853699 0.929956217779408 0.6498162047765275 11.70774391871668 0.988838105391615 0.4795847585922947 0.10790734183073776 0.15788636878890638 0.3829473993198137 1.023064201152827 1.2448815405447938e-07 6.904871972853699 11.057927713940153 up DGWSLWYSEYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGWSLWYSEYR 11 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 19801600.0 5608900.0 5414400.0 8778300.0 False True 7353322.21666487 4606592.6251659 7870005.723399498 1.0 0.6264641327325432 1.070265315664213 22.809964773371455 -6.683510831915538 1.889206307815902 0.7644107425052938 1.0686335912178755 0.3403393838249179 0.15819296221816792 0.4307804324757351 2.975484785942476 0.06711297873219994 0.17622721510316347 2.072474368510719e-07 6.683510831915538 0.30422284871258165 DGWSLWYSEYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGWSLWYSEYR 11 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 27655300.0 10501000.0 3722300.0 13432000.0 False True 10167651.502956782 5208633.80153807 9913756.248637443 1.0 0.5122750125752623 0.9750291152046758 23.277483152030122 -10.662533583831891 9.739551694412366 1.0001324519083181 0.7436520638899691 0.2903595875309094 0.1889185713035971 0.0005436188167923004 1.8835696770240783e-05 0.18301251841886296 0.06097320670401081 2.1750358327984754e-11 10.662533583831891 -0.25648038801834905 DGWSLWYSEYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGWSLWYSEYR 11 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 17180200.0 4663000.0 5427400.0 7089800.0 False True 7074111.910963202 4458838.0655302545 5688497.922430272 1.0 0.6303035803858444 0.8041289131451885 22.754117611675778 -10.111694784559427 4.775354341338414 1.0000146534948031 0.7172162467686123 0.779188760308382 0.0709638949534348 1.2239057571915631e-05 2.276719896916286e-06 0.06871442949408299 0.022903498609193464 7.732238039131357e-11 10.111694784559427 -0.28279840672619083 DGWSLWYSEYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGWSLWYSEYR 11 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 22226700.0 5608900.0 5218800.0 11399000.0 False True 7682661.904823172 4988216.159736244 8706790.969774185 1.0 0.6492822698086771 1.1333039352295413 22.873174834894346 -6.712329789312913 1.7867082528276146 0.7849035767611043 1.132256080684336 0.47623462378875725 0.14773780053528524 0.370418958613334 2.306445204335408 0.06576362368827925 0.16661219486017623 1.9394125905058784e-07 6.712329789312913 0.3473525039232317 DGWSLWYSEYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGWSLWYSEYR 11 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 18158200.0 10501000.0 3710400.0 3946800.0 False True 8732046.773177288 3690411.3387432625 4772057.632058647 1.0 0.4226284437778441 0.5464993209515598 23.0578884274644 -9.81812925165661 6.481972447216621 1.0000000112543679 0.4845638823649586 0.9584822256333907 0.05057007384477378 8.248853605182796e-09 1.4633072892045183e-09 0.04896426491341669 0.016321421151389782 1.5200950624485773e-10 9.81812925165661 -0.5154361288894093 DGYDYDGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGYDYDGYR 9 0 J3KTL2;Q07955;Q07955-3;Q07955-2 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 10898590.0 3713300.0 706490.0 6478800.0 False True 3595423.324057657 988595.1412966793 4781807.92016619 1.0 0.2749593169410129 1.3299707681624606 21.777730212468253 -6.721729695900024 1.7528397787841028 0.5597253476356191 1.3285211872292624 0.5208208666758372 0.3050355344854928 0.3519466440010071 2.1141499182425556 0.13812064483875897 0.3460640277849507 1.8978867949944425e-07 6.721729695900024 0.7687958395936433 DGYNYTLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DGYNYTLSK 9 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 131129300.0 7471300.0 76691000.0 46967000.0 False True 9794946.652172122 65249001.73917669 42107305.3792767 1.0 6.66149638749764 4.298880522227143 23.223606204251308 -9.803506628661252 8.382610329481361 1.0000000058337055 5.480188454863082 0.8274231302128014 0.9645338880194824 5.678083658295735e-09 6.813966006402091e-19 0.9339059212880357 0.3113019737626786 1.5721477964990365e-10 9.803506628661252 4.480188449029377 DGYNYTLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DGYNYTLSK 9 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 112410000.0 43424000.0 12981000.0 56005000.0 False True 42045528.88909582 18164380.99502074 41335610.38601401 1.0 0.4320169462711059 0.9831154816733456 25.325449057022844 -10.889102868562592 10.664159765135116 1.0192044918265448 0.7075662139722269 0.27295753810685575 0.22498503495510305 0.08957482463865422 0.0009314913756607859 0.18995033175222728 0.07261360779391733 1.2909134669624358e-11 10.889102868562592 -0.31163827785431797 DGYNYTLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DGYNYTLSK 9 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 410501500.0 6249600.0 397760000.0 6491900.0 False True 9481100.106960261 326776620.2869354 5208773.119499148 1.0 34.466108004390996 0.5493848879071834 23.176623036335315 -3.3482647702621198 24.47652567006362 9.99999999999978 9.654613081829988 0.0 16.00941979876686 0.0 0.0 5.270584898870677 0.0 0.00044847189296539215 3.3482647702621198 -0.34538691816979217 DGYNYTLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DGYNYTLSK 9 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 134585300.0 7471300.0 59549000.0 67565000.0 False True 10233641.51429074 56917928.27779056 51607538.54485421 1.0 5.561845038084212 5.042930072622439 23.2868162657742 -10.217109361105502 4.7550418375851295 0.9991852360895119 5.302387555367988 0.9892075014392583 0.21184614759626455 0.0018300174143216455 0.00030130025815598813 0.20514122039087382 0.06837305012606269 6.065835645756156e-11 10.217109361105502 4.303202319278475 DGYNYTLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DGYNYTLSK 9 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 49742800.0 43424000.0 4118600.0 2200200.0 False True 36108980.00937535 4096412.2843219065 2660251.6474246033 1.0 0.11344580443031935 0.07367285497219514 25.10585433245712 -13.188098059898527 0.45132884988723226 9.999999999999913 0.07378264436280259 0.9998873963996548 0.004537558541102534 16.738918699632393 0.228145097335171 146.32536057401808 0.008954547908567307 6.484879940948355e-14 13.188098059898527 -9.92621735563711 DGYNYTLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DGYNYTLSK 9 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 25628700.0 6249600.0 11477000.0 7902100.0 False True 8090230.398033348 10838294.860906178 6463998.882393027 1.0 1.3396769100099863 0.7989882320241903 22.947749358427764 -6.736895852898058 1.698311154623053 1.2028297316574792 0.7988953367141528 0.590855664379258 0.14273129636127452 0.3234432944598246 1.8305507347410221 0.0665236149460236 0.16378677173786788 1.832753877920352e-07 6.736895852898058 -0.4039343949433264 DHADSNIVIMLVGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DHADSNIVIMLVGNK 15 0 H3BSC1;P62491;H3BMH2;P62491-2;Q15907-2;Q15907;B4DQU5 H3BSC1 RAB11A;RAB11B Ras-related protein Rab-11A;Ras-related protein Rab-11B 0 3614380.0 862980.0 1641200.0 1110200.0 False True 1131375.1371102077 1396339.357347495 995327.1537903842 1.0 1.2341966086633889 0.8797498912099825 20.109645941368708 -6.728501287265711 1.7284872820316393 1.1411706396705235 0.880009430435566 0.5524058020350191 0.09846278956679412 0.33904984040243574 1.983763089728829 0.045153194921801 0.11224407194509298 1.8685241388695284e-07 6.728501287265711 -0.26116120923495745 DHADSNIVIMLVGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DHADSNIVIMLVGNK 15 0 H3BSC1;P62491;H3BMH2;P62491-2;Q15907-2;Q15907;B4DQU5 H3BSC1 RAB11A;RAB11B Ras-related protein Rab-11A;Ras-related protein Rab-11B 0 5563080.0 862980.0 1831300.0 2868800.0 False True 1182047.0271576056 1750387.110700731 2191248.524790613 1.0 1.4808100443429708 1.8537744052872167 20.1728560028916 -6.973963837050322 0.13288053525526958 0.4462256225545769 2.898032888896481 0.9999991427615045 0.00032351994075583226 0.07503620779237072 0.003999001711373938 0.022739834027060528 0.05022911373808526 1.0617839664306066e-07 6.973963837050322 2.451807266341904 DHAK(ub)FSPVATASYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DHAKFSPVATASYR 14 1 A0A2R8YEZ4;A0A2R8Y5D3;O15160-2;O15160;A0A2R8YEY5 A0A2R8YEZ4 POLR1C DNA-directed RNA polymerases I and III subunit RPAC1 1 4571000.0 1277100.0 1446300.0 1847600.0 True False 1061965.2351228201 1438508.4948319262 2233924.617662804 1.0 1.3545721152214154 2.1035760341104224 20.01830510765377 -6.958961785972336 0.449833959663226 0.9758051430867526 2.512027214981327 0.9997297129715724 0.007562999278636743 0.08007420270214825 0.022518222494681325 0.010008721504949577 0.06195644094015366 1.099102546365386e-07 6.958961785972336 1.5362220718945747 up DHAK(ub)FSPVATASYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DHAKFSPVATASYR 14 1 A0A2R8YEZ4;A0A2R8Y5D3;O15160-2;O15160;A0A2R8YEY5 A0A2R8YEZ4 POLR1C DNA-directed RNA polymerases I and III subunit RPAC1 1 17914900.0 1739200.0 3585700.0 12590000.0 True False 2251428.684757358 3386152.6429163786 10298749.184308993 1.0 1.5040017326959272 4.574317300847091 21.10240934956828 -6.935513685118288 0.7000517132992475 0.9614551623573603 5.3033519041150745 0.997515312012279 0.07873841570966726 0.08987410210268465 0.06438344022858553 0.07425420640498587 0.26988766300450456 1.1600756602546924e-07 6.935513685118288 4.341896741757714 up DHASIQMNVAEVDK ddPTM_RPMI8226_Bortezomib_1h_R1 2 DHASIQMNVAEVDK 14 0 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 65548810.0 23852010.0 20772900.0 20923900.0 False True 31270216.09319339 17673664.29213 18758895.544221386 1.0 0.5651916264172233 0.5998965753327381 24.89828585326986 -9.919798061517675 5.715690828303164 1.000000279582705 0.5825441016199965 0.9948432319278087 0.014168236067208335 19372710.830378834 12.238341153461192 71.28290176685066 0.0048501640585111696 1.202823594171448e-10 9.919798061517675 -0.4174561779627085 DHASIQMNVAEVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DHASIQMNVAEVDK 14 0 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 35256300.0 6383500.0 3359800.0 25513000.0 False True 6180859.286651231 4701385.661125536 18830379.92640613 1.0 0.7606362551043823 3.046563439338281 22.5593759903686 -6.88103383790525 1.073976028947735 0.8495034391733725 3.2118385762823647 0.9745115405275866 0.16377687648029793 0.12672007660507265 0.26676368040636006 0.11735626675700299 0.284567436493439 1.3151223608936645e-07 6.88103383790525 2.3623351371089925 up DHASIQMNVAEVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DHASIQMNVAEVDK 14 0 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 55783500.0 3131300.0 47863000.0 4789200.0 False True 4750411.028693783 39321473.694674164 3842612.5208190666 1.0 8.277488717747095 0.8089010608994959 22.179620917168453 -6.6520751243975 2.0010031733156772 5.714584384208098 0.8401800972789076 0.20256994334374623 3.1045303138950735 0.5034482093481466 3.8661625989282453 1.257204686458504 3.4393298753764987 2.228049707187885e-07 6.6520751243975 -4.87440428692919 DHASIQMNVAEVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DHASIQMNVAEVDK 14 0 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 64097840.0 23852010.0 22782030.0 17463800.0 False True 32670742.67333364 21775444.584501386 13339210.118250953 1.0 0.6665120778620939 0.4082922219316006 24.961495914792753 -7.598009554681477 0.1875521874026454 1.2298500461882014 1.7317733479026653e-15 0.9999489717965 0.001730224476888688 0.13321467320594385 0.020176717545110537 0.04156735732694576 0.0749630218615748 2.523425255335472e-08 7.598009554681477 -1.2298500461881996 down DHASIQMNVAEVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DHASIQMNVAEVDK 14 0 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 12818700.0 6383500.0 3768100.0 2667100.0 False True 5308163.086999066 3747800.4973907107 3224778.278722919 1.0 0.7060447156512488 0.6075130371599087 22.339781265802877 -13.999999999999998 0.15268433513652593 2.4275938416161322 0.5023842942359172 0.9995575274497925 0.0035069850796258305 11.968834318514377 0.12319356612650326 5.06575595354875 0.09501299172715406 1.0000000000000041e-14 13.999999999999998 -1.925209547380215 DHASIQMNVAEVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DHASIQMNVAEVDK 14 0 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 25299600.0 3131300.0 17712100.0 4456200.0 False True 4053529.57715083 16726406.064812759 3645217.324473211 1.0 4.126380663187246 0.8992699461281306 21.950747239260902 -6.65342608491568 1.9962400337683908 3.0232647535376023 0.9128536541193558 0.20793821506026422 1.333273987959437 0.5002991472747352 3.8252333663119287 0.5409299983345649 1.477135377442029 2.2211296781620273e-07 6.65342608491568 -2.1104110994182466 DHASIQMNVAEVDKVTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DHASIQMNVAEVDKVTGR 18 1 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 25176700.0 7208100.0 10572000.0 7396600.0 False True 9449888.903339704 8994698.80933324 6631270.7851972245 1.0 0.9518311697986636 0.7017300259322259 23.171865937859682 -6.938967581006957 0.6691004514423272 1.0028636582123842 0.6362861703568654 0.9980255018542857 0.005809457749961852 0.08824086069972979 0.056778566180206956 0.005611769705777046 0.021625472240074262 1.1508862965114408e-07 6.938967581006957 -0.3665774878555188 DHASIQMNVAEVDKVTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DHASIQMNVAEVDKVTGR 18 1 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 23041600.0 4384800.0 4587800.0 14069000.0 False True 4245606.924118169 6419732.465060945 10383906.839047063 1.0 1.5120882784960954 2.44580033541467 22.017539376065272 -6.961812288813792 0.40909201315028904 0.9535467335672073 3.0389416869225814 0.9998316196182877 0.0077669093272496855 0.07905998138206824 0.018785293169069656 0.0120204343607326 0.07798102497634055 1.0919121818230511e-07 6.961812288813792 2.085394953355374 DHASIQMNVAEVDKVTGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DHASIQMNVAEVDKVTGR 18 1 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 146301000.0 17559000.0 95172000.0 33570000.0 False True 26638286.73484941 78187813.01776996 26934874.78574631 1.0 2.9351667318559618 1.0111339011344485 24.66699796138722 -6.644834115504624 2.027055485854008 2.260805536136031 1.0191876922896395 0.17342749505525445 0.8270026170925978 0.5212436815691129 4.099134056273529 0.33156824870679397 0.9158228162224352 2.2655094835252815e-07 6.644834115504624 -1.2416178438463916 DHASIQMNVAEVDKVTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DHASIQMNVAEVDKVTGR 18 1 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 27990000.0 7208100.0 8001900.0 12780000.0 False True 9873129.36157819 7648349.599255276 9761627.21236198 1.0 0.7746631609041036 0.9887065037707166 23.235075999382573 -10.584836735192622 8.191598194629359 1.0000470099482552 0.8816848323585538 0.2894676272929122 0.08738282881046523 7.505134775977563e-05 3.803793654722066e-06 0.08464161149063844 0.028202686727285455 2.6011372277961546e-11 10.584836735192622 -0.11836217758970147 DHASIQMNVAEVDKVTGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DHASIQMNVAEVDKVTGR 18 1 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 86526000.0 17559000.0 42162000.0 26805000.0 False True 22730471.639635697 39815647.63662332 21926765.042526044 1.0 1.7516419486516845 0.9646418864574632 24.43812428347967 -6.656563032788011 1.9848454128728101 1.4851730412468427 0.9679202366953433 0.22123220047666525 0.32029419702401907 0.4926200736951886 3.726969356521328 0.1305322127901895 0.3549965690921849 2.2051440621773546e-07 6.656563032788011 -0.5172528045514994 DHAVVVGVYRPPPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DHAVVVGVYRPPPK 14 1 P22087 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 161753000.0 59122000.0 49647000.0 52984000.0 False True 77509514.53826243 42239861.122490264 47501723.93841619 1.0 0.544963561881666 0.6128502316314606 26.207870080851865 -10.594302429309181 6.45457530477596 1.0010133806502772 0.5789068967566035 0.9808799125278543 0.0277146168706385 0.00040503833564845915 2.545836086502142e-05 0.02689302515378125 0.008944854132208493 2.5450573357651068e-11 10.594302429309181 -0.4221064838936738 DHAVVVGVYRPPPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DHAVVVGVYRPPPK 14 1 P22087 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 101096000.0 22640000.0 12776000.0 65680000.0 False True 21921305.592509437 17877523.425959844 48476437.64223556 1.0 0.8155318737980933 2.2113846019645873 24.385830389323235 -6.873613735165081 1.1147343677797041 0.8929916552554371 2.2989739157481885 0.9681618864692106 0.11047265185899736 0.13344055423967477 0.3077154434024773 0.07672655472513798 0.18289238465061694 1.3377848236359408e-07 6.873613735165081 1.4059822604927514 up DHAVVVGVYRPPPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DHAVVVGVYRPPPK 14 1 P22087 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 102865000.0 23273000.0 42584000.0 37008000.0 False True 35306842.48420475 34984552.48968937 29693352.57881735 1.0 0.9908717412309085 0.8410084416951555 25.073444469844123 -6.91936158258921 0.8294539511196336 1.0033833455159056 0.8171934536196196 0.9940016018808671 0.005645519309102223 0.09854885789630646 0.10757347464273805 0.004847816812861228 0.014433937880012798 1.2040330754974746e-07 6.91936158258921 -0.186189891896286 DHAVVVGVYRPPPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DHAVVVGVYRPPPK 14 1 P22087 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 126280000.0 59122000.0 25440000.0 41718000.0 False True 80981001.11197475 24315976.681169998 31865067.609179735 1.0 0.3002676720129404 0.3934881907068424 26.271080142374757 -10.7516634775213 7.032194298719008 1.0117123402675565 0.3468779313598914 0.9849509122968138 0.038057117392940064 0.006866482038835178 0.00024248426800579516 0.03620624734545485 0.012282881822293118 1.7714810971011486e-11 10.7516634775213 -0.6648344089076651 DHAVVVGVYRPPPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DHAVVVGVYRPPPK 14 1 P22087 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 60670000.0 22640000.0 23032000.0 14998000.0 False True 18826163.12205827 22907922.044505958 18134012.45708311 1.0 1.2168131071628274 0.963234639980136 24.16623566475751 -6.680323082437879 1.9005955350392327 1.1371440096516552 0.964195822850899 0.3255432430533205 0.09188483963642197 0.4378790397818221 3.0583698801297134 0.0387872711770309 0.10226188317885798 2.0877424296268412e-07 6.680323082437879 -0.1729481868007562 DHAVVVGVYRPPPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DHAVVVGVYRPPPK 14 1 P22087 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 92024000.0 23273000.0 40964000.0 27787000.0 False True 30127357.279414676 38684317.389749974 22730051.118696935 1.0 1.2840262433566343 0.7544654815849996 24.844570791936572 -6.761023389477015 1.6086929703909378 1.1647684610100921 0.7524372076371753 0.6951085737415175 0.11947990219694059 0.281198776691239 1.4344901566778792 0.05859522204870725 0.14066738961529945 1.7337106240677273e-07 6.761023389477015 -0.4123312533729169 DHENIVIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DHENIVIAK 9 0 P07237;H7BZ94;H0Y3Z3 P07237 P4HB Protein disulfide-isomerase 0 24297500.0 6711100.0 2036400.0 15550000.0 False True 6498059.8039704105 2849545.1396857095 11476988.50999942 1.0 0.43852245526343037 1.7662177413305447 22.631577590691556 -6.791818337117602 1.4890420031354865 0.6869221073030776 1.7810541735836078 0.8071393303407679 0.23897863783026196 0.2326685674488845 1.0190923097836238 0.12631124480872918 0.2953409941524345 1.6150339749720206e-07 6.791818337117602 1.0941320662805303 DHFQLGTLSHTLNIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DHFQLGTLSHTLNIK 15 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 17783500.0 9556400.0 3000500.0 5226600.0 False True 12528532.944309236 2552837.0958573916 4685801.56908739 1.0 0.20376185361885904 0.37401039610274517 23.578714153262066 -10.367234696679756 8.618384505183641 1.00000250336665 0.28888612505002453 0.9587835720679767 0.06950367642301086 3.3431725570605767e-06 2.45570427923665e-07 0.0672968813139 0.02243221510720918 4.2930436409134866e-11 10.367234696679756 -0.7111163783166254 DHFQLGTLSHTLNIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DHFQLGTLSHTLNIK 15 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 11129400.0 9556400.0 1573000.0 0.0 False True 13089659.331999512 1503499.6587846053 0.0 1.0 0.11486163395475764 0.0 23.641924214784957 -10.609646900016237 0.4208481078623613 1.6849726912225085 2.8933157918314875e-19 0.9992354534147139 0.012354182175657745 2.3626152278943318 0.224087193443565 1.7243974039218666 0.028452964247827447 2.456705510542765e-11 10.609646900016237 -1.6849726912225085 DHIMEIFSTYGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DHIMEIFSTYGK 12 0 H3BV80;H3BMS0;H3BMM9;H3BTC0;Q15287-3;Q15287-2;Q15287 H3BV80 RNPS1 RNA-binding protein with serine-rich domain 1 0 33171900.0 10234000.0 9512900.0 13425000.0 False True 13416873.106196987 8093612.4009937765 12035909.7816933 1.0 0.6032413317865769 0.8970726402811512 23.677545145003002 -9.817041334886357 5.621983690718481 1.0000000558589601 0.7501569860321043 0.49083502135416246 0.11995612938388164 8.40060717505806e-08 1.754743579261622e-08 0.11614704880293314 0.038715674280703105 1.5239077057891183e-10 9.817041334886357 -0.24984306982685578 DHIMEIFSTYGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DHIMEIFSTYGK 12 0 H3BV80;H3BMS0;H3BMM9;H3BTC0;Q15287-3;Q15287-2;Q15287 H3BV80 RNPS1 RNA-binding protein with serine-rich domain 1 0 25904400.0 8109000.0 3807400.0 13988000.0 False True 7851584.233642181 5327714.675328703 10324123.168994978 1.0 0.6785528266385662 1.3149095598769165 22.90455234885984 -6.769345745185558 1.576753514491282 0.8154787554412096 1.3184205050686446 0.7281652215499375 0.1354519206135973 0.26746714443452047 1.312197893794492 0.06771453554032436 0.1612990564379256 1.7008039461426345e-07 6.769345745185558 0.502941749627435 DHIMEIFSTYGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DHIMEIFSTYGK 12 0 H3BV80;H3BMS0;H3BMM9;H3BTC0;Q15287-3;Q15287-2;Q15287 H3BV80 RNPS1 RNA-binding protein with serine-rich domain 1 0 29818500.0 3675200.0 17977000.0 8166300.0 False True 5575547.093110015 14768863.895057919 6552227.225583558 1.0 2.6488636269091064 1.1751720712179934 22.410681943826447 -6.6191677596526235 2.1193745531040387 2.0946694945147666 1.1807141742583611 0.08014172102765171 0.7092100153378141 0.5876349919404115 5.014282849097492 0.27504215322083564 0.7866439040855345 2.4034342199978154e-07 6.6191677596526235 -0.9139553202564055 DHIMEIFSTYGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DHIMEIFSTYGK 12 0 H3BV80;H3BMS0;H3BMM9;H3BTC0;Q15287-3;Q15287-2;Q15287 H3BV80 RNPS1 RNA-binding protein with serine-rich domain 1 0 28695000.0 10234000.0 7992000.0 10469000.0 False True 14017786.363451002 7638887.01399019 7996437.815822979 1.0 0.544942462092823 0.5704493996764235 23.740755206525893 -10.600309723456334 6.4362383542651385 1.0011836384023083 0.5576959308846235 0.9975119776042681 0.010413163663473342 0.00017728108347082248 1.1009142861940113e-05 0.010106366115531928 0.003360834120830375 2.5100956816191077e-11 10.600309723456334 -0.44348770751768474 DHIMEIFSTYGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DHIMEIFSTYGK 12 0 H3BV80;H3BMS0;H3BMM9;H3BTC0;Q15287-3;Q15287-2;Q15287 H3BV80 RNPS1 RNA-binding protein with serine-rich domain 1 0 17086700.0 8109000.0 4040900.0 4936800.0 False True 6742992.789610003 4019130.8696441473 5969062.054815822 1.0 0.5960455535169871 0.885224445740666 22.684957624294118 -10.001334436845262 6.158154779777252 1.0000001836429495 0.7406349996288126 0.517508773964525 0.1180567883886008 2.976162029008914e-07 4.840439371048979e-08 0.11430807559262404 0.038102664611307964 9.969320613838349e-11 10.001334436845262 -0.2593651840141369 DHIMEIFSTYGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DHIMEIFSTYGK 12 0 H3BV80;H3BMS0;H3BMM9;H3BTC0;Q15287-3;Q15287-2;Q15287 H3BV80 RNPS1 RNA-binding protein with serine-rich domain 1 0 20344900.0 3675200.0 10485000.0 6184700.0 False True 4757618.849022683 9901500.53294426 5059148.060380931 1.0 2.0811882681560845 1.0633781773880833 22.181808265918896 -6.631961612878594 2.073110158666019 1.711305775748431 1.0674970110131439 0.12450820871827728 0.46354830665469815 0.5540597593625585 4.540322346079421 0.18270820549449718 0.5135215314068502 2.3336643248528773e-07 6.631961612878594 -0.643808764735287 DHIVLTVLPDQDQSDEAQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DHIVLTVLPDQDQSDEAQEK 20 0 Q8IUF8-4;Q8IUF8;Q8IUF8-3 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 0 10863700.0 3302000.0 4400600.0 3161100.0 False True 4328953.9766134815 3744047.633404449 2834019.69541234 1.0 0.8648850631425281 0.6546661643257707 22.045587031906216 -6.964642474094551 0.3641353411193046 1.0172799681869817 0.49502074588663236 0.999905584253783 0.001380634741029443 0.07808247971335033 0.015288944652369185 0.002798075577654024 0.01791193301848122 1.0848196067124928e-07 6.964642474094551 -0.5222592223003494 DHLLSVSLSGYINYLDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DHLLSVSLSGYINYLDR 17 0 O75083;O75083-3 O75083 WDR1 WD repeat-containing protein 1 0 33341000.0 10793000.0 10586000.0 11962000.0 False True 16373770.073992273 8696845.59120449 9597705.456869159 1.0 0.5311449685627603 0.5861634439409857 23.964883205988755 -10.102872245676839 4.880053786645625 1.0000176620970365 0.558654206251527 0.9884790607725867 0.022461198531929058 4.51674018986477e-06 8.302902083272973e-07 0.021748871646869693 0.007249320652012942 7.89092206947515e-11 10.102872245676839 -0.4413634558455095 DHLVTAYNHLFETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DHLVTAYNHLFETK 14 0 Q00688 Q00688 FKBP3 Peptidyl-prolyl cis-trans isomerase FKBP3 0 15829300.0 4032100.0 4614100.0 7183100.0 False True 5286122.146911938 3925694.2656209264 6439861.717160608 1.0 0.7426416107153805 1.218258212387821 22.333778331176173 -6.759761978102236 1.6135165549292128 0.8504666103062996 1.219966347942655 0.689939613835427 0.10824134005060067 0.28331651700012905 1.4537039478601308 0.0529328936949834 0.12722835921027387 1.7387535187756667e-07 6.759761978102236 0.36949973763635546 DHLVTAYNHLFETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DHLVTAYNHLFETK 14 0 Q00688 Q00688 FKBP3 Peptidyl-prolyl cis-trans isomerase FKBP3 0 11231400.0 4266300.0 0.0 6965100.0 False True 4130868.641754556 0.0 5140731.361478907 1.0 0.0 1.2444674007584562 21.978013753724845 -6.692767761210846 1.8563704538237062 0.37471183912608746 1.2403445339297983 0.3835370859387157 0.42269255467208783 0.4107290047825103 2.7462947609804313 0.18200303672839613 0.47233849399826616 2.028767311958418e-07 6.692767761210846 0.8656326948037107 DHLVTAYNHLFETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DHLVTAYNHLFETK 14 0 Q00688 Q00688 FKBP3 Peptidyl-prolyl cis-trans isomerase FKBP3 0 18792000.0 4032100.0 8281000.0 6478900.0 False True 5522876.333405382 7915118.038394987 4948717.257133963 1.0 1.4331514161416246 0.8960398456147586 22.396988392699065 -6.692084907629219 1.8589008617964817 1.2710270295865669 0.8978440407522916 0.38021574207097986 0.1831160247953532 0.4122223415574133 2.7633048561243148 0.07875562694076439 0.20455584616208744 2.0319597096689672e-07 6.692084907629219 -0.37318298883427525 DHNNEIVK(ub)IQSLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DHNNEIVKIQSLLR 14 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2;D6R939;E9PDT6 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 1 6541400.0 2996100.0 2097100.0 1448200.0 True False 3927916.114273673 1784220.8544317754 1298354.1561153238 1.0 0.45424107911777617 0.33054528618807016 21.905332688688173 -13.999999999999998 0.20856320689508437 4.137827978202357 0.25666561825410844 0.9994892552587463 0.006573021044398841 12.71344303344943 0.14476061435019724 16.33597802422955 0.07401589640235774 1.0000000000000041e-14 13.999999999999998 -3.8811623599482488 DHNNEIVK(ub)IQSLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DHNNEIVKIQSLLR 14 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2;D6R939;E9PDT6 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 1 6064600.0 2996100.0 1583600.0 1484900.0 True False 4103839.136558093 1513631.3157350956 1134197.202475454 1.0 0.3688330037723127 0.2763746737467663 21.968542750211064 -13.999999999999998 0.27050722255280224 5.884870586681713 0.24583495704344638 0.9995844196972847 0.006555062379349833 14.907955086554622 0.16464824331902833 40.060122381646885 0.038302838611372673 1.0000000000000041e-14 13.999999999999998 -5.639035629638267 DHPESYHSFMWNNFFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DHPESYHSFMWNNFFK 16 0 D6RAY7;D6R9P4;P46926;D6RB13;D6R917;D6RFF8 D6RAY7 GNPDA1 Glucosamine-6-phosphate isomerase;Glucosamine-6-phosphate isomerase 1 0 17390400.0 4599600.0 3307200.0 9483600.0 False True 6030120.142589754 2813778.651364632 8502328.045114828 1.0 0.46662066174956823 1.4099765583548283 22.52375531562727 -6.753327771568102 1.6377332252052748 0.687625334294184 1.4123150126583266 0.6630970688836102 0.2241751251321769 0.2942691536442384 1.553906367454327 0.10809045972960958 0.26148314873159706 1.764705456065293e-07 6.753327771568102 0.7246896783641426 DHPESYHSFMWNNFFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DHPESYHSFMWNNFFK 16 0 D6RAY7;D6R9P4;P46926;D6RB13;D6R917;D6RFF8 D6RAY7 GNPDA1 Glucosamine-6-phosphate isomerase;Glucosamine-6-phosphate isomerase 1 0 18962500.0 4731500.0 3403000.0 10828000.0 False True 4581301.122392159 4761835.646410559 7991821.966962953 1.0 1.0394068233445726 1.7444437188162751 22.127325961585115 -6.918415144518474 0.8363794396037645 0.9835387141466679 1.8541003110741112 0.9937298481197387 0.027082960939062505 0.09911263221464969 0.11050568363285795 0.023141238157756736 0.06830451619388528 1.2066598307700564e-07 6.918415144518474 0.8705615969274433 DHPESYHSFMWNNFFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DHPESYHSFMWNNFFK 16 0 D6RAY7;D6R9P4;P46926;D6RB13;D6R917;D6RFF8 D6RAY7 GNPDA1 Glucosamine-6-phosphate isomerase;Glucosamine-6-phosphate isomerase 1 0 24583600.0 4599600.0 8228000.0 11756000.0 False True 6300196.419516232 7864459.753642556 8979474.922419995 1.0 1.2482880262717966 1.4252690431371495 22.58696537715016 -6.974781463045972 0.08670533089916424 0.4503793246454402 2.2276337206257506 0.9999998586139719 6.533226535217051e-05 0.07477938170556261 0.0025244360408913707 0.019229149465317643 0.03226752707086702 1.0597868757098236e-07 6.974781463045972 1.7772543959803104 DHPESYHSFMWNNFFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DHPESYHSFMWNNFFK 16 0 D6RAY7;D6R9P4;P46926;D6RB13;D6R917;D6RFF8 D6RAY7 GNPDA1 Glucosamine-6-phosphate isomerase;Glucosamine-6-phosphate isomerase 1 0 12897800.0 4731500.0 3422900.0 4743400.0 False True 3934451.890990228 3404460.1583075467 5735223.00899639 1.0 0.865294646530983 1.4576930072851753 21.90773123701939 -6.846927025702573 1.2497660527751593 0.9282608169499603 1.4800153486576662 0.9357210599884047 0.06428192741571336 0.16087075529576936 0.48506148935630494 0.04027705672306053 0.09304224309524987 1.4225678004396945e-07 6.846927025702573 0.5517545317077058 DHPFGFVAVPTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DHPFGFVAVPTK 12 0 H3BQQ9;B0QYN7;P63279;H3BPC4 H3BQQ9 UBE2I SUMO-conjugating enzyme UBC9 0 13514600.0 1198600.0 7047000.0 5269000.0 False True 1571376.207258911 5995615.068990855 4723814.423816909 1.0 3.8155185507419196 3.006163897604808 20.583597190676027 -10.146103888029488 5.7871579737134375 0.9999724237458119 3.4108412241734696 0.9220599070074004 0.33041765352257296 0.00011756385511344893 1.7345603308640764e-05 0.3199291345060831 0.10664183911543357 7.143254311156162e-11 10.146103888029488 2.4108688004276577 DHPFGFVAVPTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DHPFGFVAVPTK 12 0 H3BQQ9;B0QYN7;P63279;H3BPC4 H3BQQ9 UBE2I SUMO-conjugating enzyme UBC9 0 11837600.0 4253200.0 1182300.0 6402100.0 False True 4118184.494083977 1654398.5556130498 4725197.951116869 1.0 0.401730072557384 1.1473983154239213 21.973577033276317 -6.693172708516528 1.8560240673628012 0.6260251870823385 1.1448616428357181 0.3849593193072598 0.25286750087007753 0.40986056246369645 2.7400433681217216 0.1089147535196939 0.2824005839819728 2.0268765189693473e-07 6.693172708516528 0.5188364557533797 DHPFGFVAVPTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DHPFGFVAVPTK 12 0 H3BQQ9;B0QYN7;P63279;H3BPC4 H3BQQ9 UBE2I SUMO-conjugating enzyme UBC9 0 13873500.0 1198600.0 5550600.0 7124300.0 False True 1641754.8109470743 5305356.138620371 5441687.0695641935 1.0 3.2315155120878774 3.314555275415982 20.64680725219892 -10.440862096032877 0.6474973025803304 1.6882772035497908e-12 3.3024535976503646 0.9998673182339575 0.012348743356934075 1.817100479247367 0.32042330174080996 3.1263279675136797 0.013624316331897644 3.623580417356248e-11 10.440862096032877 3.302453597648676 DHQTITIQEMPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DHQTITIQEMPEK 13 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 16259300.0 2988400.0 8531300.0 4739600.0 False True 3917821.3397067706 7258463.294746937 4249191.657453523 1.0 1.8526784826002805 1.0845802523939374 21.901620178722435 -10.21501659973067 4.30177899799362 0.9998048271682473 1.4686293675141537 0.3316949971318809 0.3135747894481273 32700378.14980112 79349375.07466099 35517.13465863249 0.10734497956715579 6.095135997879041e-11 10.21501659973067 0.4688245403459065 DHQTITIQEMPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DHQTITIQEMPEK 13 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 7445260.0 2333180.0 731380.0 4380700.0 False True 2259114.4780181614 1023423.8480963153 3233263.2518170075 1.0 0.4530199146853893 1.431208238129407 21.10732594881323 -6.7549888362160395 1.6315907208265992 0.6803015070836348 1.4338894176633892 0.670046524249778 0.22992422996710923 0.2914352478925838 1.5278765528184535 0.11125806357925234 0.26868296225761157 1.757968802954874e-07 6.7549888362160395 0.7535879105797544 DHQTITIQEMPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DHQTITIQEMPEK 13 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 17112000.0 2988400.0 6775200.0 7348400.0 False True 4093292.238473421 6475849.261409713 5612859.265048575 1.0 1.5820637482323663 1.3712334566031061 21.964830240245327 -10.06149980859145 4.503154425082203 0.9999738286981009 1.476648602292278 0.8720418467201388 0.08607110624589118 29842273.06766471 0.5098193449262864 8760.958028665718 0.029464429008666856 8.679609598326117e-11 10.06149980859145 0.4766747735941771 DHVLHVTFPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DHVLHVTFPK 10 0 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;O95453-3;A0A494C0K5;A0A494C1G3;O95453-4 O95453 PARN Poly(A)-specific ribonuclease PARN 0 10675300.0 3221100.0 1967300.0 5486900.0 False True 4222893.293176777 1673786.50847534 4919168.222061305 1.0 0.3963601237994324 1.1648810141638077 22.009800361964295 -6.697269492776516 1.841048314311272 0.6241586088414401 1.1624496137542102 0.40447302483388237 0.2549338386833938 0.40120529758318824 2.641935314236882 0.11056251852228964 0.2852532758225068 2.0078464968736907e-07 6.697269492776516 0.53829100491277 DHVLHVTFPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DHVLHVTFPK 10 0 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;O95453-3;A0A494C0K5;A0A494C1G3;O95453-4 O95453 PARN Poly(A)-specific ribonuclease PARN 0 9186200.0 3221100.0 2514800.0 3450300.0 False True 4412027.71695447 2403687.8206684855 2635410.2011590423 1.0 0.5448034271026069 0.597324035620114 22.073010423487187 -10.329071721831774 5.444510753367588 1.0000953922244546 0.5710637313628124 0.9888806567654925 0.021441448641430643 2.483288745817867e-05 3.060174226719356e-06 0.020765180405312465 0.006920197792229916 4.687359660609252e-11 10.329071721831774 -0.42903166086164224 DHVLHVTFPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DHVLHVTFPK 10 0 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;O95453-3;A0A494C0K5;A0A494C1G3;O95453-4 O95453 PARN Poly(A)-specific ribonuclease PARN 0 3774920.0 1467300.0 937020.0 1370600.0 False True 1220124.9624114893 931972.0872760931 1657186.1230616118 1.0 0.7638333088720004 1.3582101621675722 20.21859748220985 -6.798879099697538 1.4603902800633253 0.8695120917657356 1.3661996501811322 0.8289043003304597 0.10107325239569939 0.2223533338805572 0.9363285281963425 0.05444918918435657 0.12672151351473854 1.5889890349390075e-07 6.798879099697538 0.4966875584153966 DHVYLQLHHLPPEQLATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DHVYLQLHHLPPEQLATR 18 0 P31040-2;P31040;D6RFM5;A0A087X1I3;P31040-3 P31040-2 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0 9649200.0 2996300.0 4179100.0 2473800.0 False True 3928178.316210477 3555594.570004208 2217834.906365204 1.0 0.9051510099048402 0.5645962906553476 21.905428990339693 -6.947358037938281 0.587132338552147 1.0039712542892474 0.4487240026335638 0.9989773113333626 0.005978541847771839 0.0845642803876521 0.04048888694941208 0.00621664086462685 0.028505824095744564 1.1288648802685024e-07 6.947358037938281 -0.5552472516556836 DHVYLQLHHLPPEQLATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DHVYLQLHHLPPEQLATR 18 0 P31040-2;P31040;D6RFM5;A0A087X1I3;P31040-3 P31040-2 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0 9504500.0 3295700.0 1336700.0 4872100.0 False True 3191079.8074749713 1870451.280798414 3595950.8501330013 1.0 0.5861499535100815 1.12687587496547 21.6056132595486 -6.702183849082202 1.8229629958636469 0.7435662115475205 1.1253401459037673 0.42796055325496596 0.17462281213962164 0.3910195554499818 2.527746194584765 0.07637409281436561 0.19589490715642385 1.985254325393966e-07 6.702183849082202 0.38177393435624685 DHVYLQLHHLPPEQLATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DHVYLQLHHLPPEQLATR 18 0 P31040-2;P31040;D6RFM5;A0A087X1I3;P31040-3 P31040-2 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0 14160400.0 2996300.0 3681900.0 7482200.0 False True 4104113.0819628914 3519221.4835848953 5715058.460746069 1.0 0.8574864808310161 1.3925197348638123 21.968639051862585 -6.835850218924164 1.3015633900971937 0.9241006748824109 1.4087162373263626 0.9170741842336262 0.06514867515518526 0.17370273220139823 0.5733995151726106 0.03927419443783545 0.09040249952243268 1.4593174682639514e-07 6.835850218924164 0.48461556244395176 DHYEATAMHR ddPTM_RPMI8226_Bortezomib_1h_R1 2 DHYEATAMHR 10 0 B1AJY7;O75832;B1AJY5;O75832-2;B1AJY6 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 6667270.0 771920.0 3088950.0 2806400.0 False True 1011994.595283914 2628090.700632796 2516020.648889691 1.0 2.5969414390948287 2.486199689815363 19.948770154437508 -10.079019970983756 4.540116134506663 0.9999014381772284 2.5415705644843642 0.9961445101695151 0.04521013008790508 7851196.714915256 1.7325534689828708 8333.460147196063 0.01547663000868094 8.336428487639318e-11 10.079019970983756 1.5416691263071358 DHYEATAMHR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DHYEATAMHR 10 0 B1AJY7;O75832;B1AJY5;O75832-2;B1AJY6 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 6606450.0 771920.0 2554500.0 3280030.0 False True 1057319.6843536345 2441633.7433981397 2505354.468338314 1.0 2.3092672722638 2.3695335530141945 20.0119802159604 -10.761222444861911 0.5639071336048643 1.5162158652407493e-18 2.3638347354706397 0.999835855043099 0.00809556756599454 2.351029160748944 0.2745413259527485 3.210922343213921 0.011010356614333566 1.732916173817704e-11 10.761222444861911 2.3638347354706397 DHYSNGFCTVYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DHYSNGFCTVYAK 13 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 9671300.0 2047900.0 4263500.0 3359900.0 False True 2684816.7318918123 3627402.4189928356 3012249.778436594 1.0 1.3510800852454632 1.121957317479194 21.356392181179285 -10.131939884495818 4.711992106827315 0.9999807881459848 1.2365187013648617 0.5869135645484006 0.09353897825562059 1.8880237257071562e-05 3.478200271256383e-06 0.09057607936549575 0.030189575415875015 7.380063786872016e-11 10.131939884495818 0.23653791321887696 DHYSNGFCTVYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DHYSNGFCTVYAK 13 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 9839100.0 2047900.0 3415100.0 4376100.0 False True 2805063.972416583 3264209.589774513 3342555.30860855 1.0 1.163684544050656 1.1916146446132259 21.419602242702176 -13.755961145528046 0.25151510258485904 1.005761636756477e-11 1.2027872476000725 0.9995323166137648 0.0018277656999769565 12.454114177531649 0.15773811888436792 6.276145546206094 0.012791429466357545 1.754037421056881e-14 13.755961145528046 1.202787247590015 DIAAHIK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIAAHIKK 8 1 P63167;F8VXL2;F8VRV5 P63167 DYNLL1 Dynein light chain 1, cytoplasmic 1 4796400.0 1262500.0 1863700.0 1670200.0 True False 1655149.7260673929 1585643.2246456996 1497383.7256896957 1.0 0.9580059131044056 0.9046817348950379 20.65853029951948 -6.967877851883809 0.3046434899554472 1.0087523934578642 0.852253271807563 0.9999607539340906 0.00024428545596793936 0.07699751333792113 0.0114820368307632 0.0008649239208247743 0.004759410062366795 1.0767680189754098e-07 6.967877851883809 -0.1564991216503011 DIAAHIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIAAHIKK 8 1 P63167;F8VXL2;F8VRV5 P63167 DYNLL1 Dynein light chain 1, cytoplasmic 1 5887300.0 1263000.0 2449700.0 2174600.0 True False 1222906.7563312477 3427877.9850167395 1605007.0233983775 1.0 2.80305752443503 1.3124524949174707 20.221882975391544 -6.59921652207297 2.193425261398475 2.2131981847098934 1.3172236353557327 0.01832964977615803 0.7794898750910397 0.6429667861572166 5.844881029971025 0.2951019382254619 0.867314335946743 2.5164220263452756e-07 6.59921652207297 -0.8959745493541607 DIAAHIK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIAAHIKK 8 1 P63167;F8VXL2;F8VRV5 P63167 DYNLL1 Dynein light chain 1, cytoplasmic 1 20223700.0 1749800.0 3228900.0 15245000.0 True False 2654574.5275152065 2652677.5674891532 12231819.067879124 1.0 0.9992853995974154 4.607826580528753 21.34004921519993 -6.906846315623769 0.9169185347507833 0.8768256680214711 5.044067801291088 0.9896766572532156 0.1728194364457408 0.10654130847761589 0.1503431946567978 0.1393193915523621 0.37668985842593494 1.2392350387287096e-07 6.906846315623769 4.167242133269617 up DIAAHIK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIAAHIKK 8 1 P63167;F8VXL2;F8VRV5 P63167 DYNLL1 Dynein light chain 1, cytoplasmic 1 3968200.0 1262500.0 1028500.0 1677200.0 True False 1729280.3677796458 983057.4692053195 1281079.9030182718 1.0 0.5684777827366082 0.7408167737792267 20.72174036104237 -10.128962558206087 5.218484703737141 1.0000098348404023 0.654647278257604 0.8426246368433554 0.07035709847451055 8.050624612070303e-06 1.3438361328404707e-06 0.0681249066084256 0.022707655889780277 7.430831985049949e-11 10.128962558206087 -0.34536255658279824 DIAAHIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIAAHIKK 8 1 P63167;F8VXL2;F8VRV5 P63167 DYNLL1 Dynein light chain 1, cytoplasmic 1 6468100.0 1263000.0 2703000.0 2502100.0 True False 1050240.4603869088 2688438.4024965093 3025277.5415967186 1.0 2.5598312994969628 2.8805570302273495 20.00228825082582 -10.202141175138205 0.3579588136497625 3.0666240859441545e-14 2.9384675647608898 0.9989789513221 0.02624722168712598 1.601444485796089 0.16459008529844166 1.6725037616944145 0.09245372278973281 6.278542304635554e-11 10.202141175138205 2.938467564760859 DIAAHIK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIAAHIKK 8 1 P63167;F8VXL2;F8VRV5 P63167 DYNLL1 Dynein light chain 1, cytoplasmic 1 18536000.0 1749800.0 2128200.0 14658000.0 True False 2265150.593714594 2009763.7991618493 11990394.403780868 1.0 0.887253944500909 5.293420418515292 21.11117553729238 -6.901029935743665 0.9547535175838977 0.8219488015468152 5.765685988949983 0.9870712295268973 0.23321172363388323 0.11065048548955626 0.17318344437541783 0.18284191514390363 0.47821880068183814 1.2559433890393304e-07 6.901029935743665 4.943737187403167 up DIDAATEAK(ub)HR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIDAATEAKHR 11 1 Q96SU4-3;Q96SU4-7;Q96SU4-2;Q96SU4;Q96SU4-6;Q96SU4-5;Q96SU4-4;A0A096LPC8 Q96SU4-3 OSBPL9 Oxysterol-binding protein-related protein 9 1 1839990.0 408350.0 763590.0 668050.0 True False 535350.8044670257 649665.3484505073 598926.5943880978 1.0 1.2135320298944703 1.1187553831816235 19.030125044471898 -10.171093272309635 4.364367344828281 0.9999599291230777 1.1661437065447695 0.8038199132181172 0.03869240401911925 27122838.34206947 0.8353286035597036 10922.014411712567 0.013245439049998703 6.74383176602321e-11 10.171093272309635 0.16618377742169177 DIDAATEAK(ub)HR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIDAATEAKHR 11 1 Q96SU4-3;Q96SU4-7;Q96SU4-2;Q96SU4;Q96SU4-6;Q96SU4-5;Q96SU4-4;A0A096LPC8 Q96SU4-3 OSBPL9 Oxysterol-binding protein-related protein 9 1 2131480.0 605770.0 638800.0 886910.0 True False 586540.162931734 893876.1712979926 654601.6642703274 1.0 1.5239811828572576 1.116038944372365 19.161870373617443 -9.83529551065885 6.120082554218895 0.9999999761756783 1.320010063615026 0.45069469854984745 0.1665417214702243 5.399253562031297e-08 1.0208100361903457e-08 0.16125334043967773 0.053751109475128796 1.4611825913188843e-10 9.83529551065885 0.3200100874393478 DIDAATEAK(ub)HR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIDAATEAKHR 11 1 Q96SU4-3;Q96SU4-7;Q96SU4-2;Q96SU4;Q96SU4-6;Q96SU4-5;Q96SU4-4;A0A096LPC8 Q96SU4-3 OSBPL9 Oxysterol-binding protein-related protein 9 1 5276620.0 674120.0 945400.0 3657100.0 True False 1022689.3247734318 776685.9835560861 2934272.582036127 1.0 0.7594544743372131 2.8691729843627636 19.963936515305807 -6.878545252706412 1.0879180515823332 0.8536092231661804 3.0145562699313473 0.9724912699027419 0.15639723913020534 0.1289247475608545 0.28016023863412476 0.11088410789036848 0.26717462471424136 1.3226798799571474e-07 6.878545252706412 2.160947046765167 up DIDAATEAK(ub)HR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIDAATEAKHR 11 1 Q96SU4-3;Q96SU4-7;Q96SU4-2;Q96SU4;Q96SU4-6;Q96SU4-5;Q96SU4-4;A0A096LPC8 Q96SU4-3 OSBPL9 Oxysterol-binding protein-related protein 9 1 1884870.0 408350.0 615940.0 860580.0 True False 559328.0302438166 588725.7341587986 657328.7282014453 1.0 1.0525589677709648 1.175211490679109 19.09333510599479 -6.956920069579859 0.47686245664534893 0.9969672878424806 1.2358898449218114 0.9996383579769867 0.0013960739292119472 0.08082024796001933 0.025339997198711443 0.001718511215076048 0.010119091231423637 1.1042818405119125e-07 6.956920069579859 0.23892255707933086 DIDAATEAK(ub)HR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIDAATEAKHR 11 1 Q96SU4-3;Q96SU4-7;Q96SU4-2;Q96SU4;Q96SU4-6;Q96SU4-5;Q96SU4-4;A0A096LPC8 Q96SU4-3 OSBPL9 Oxysterol-binding protein-related protein 9 1 2204440.0 605770.0 1028600.0 570070.0 True False 503724.59516118595 1023058.7276388851 689269.0012941299 1.0 2.0309882373552126 1.368344940698343 18.94227564905172 -10.191281296215942 4.926206306819853 0.9999273943512036 1.6996665890280962 0.5978263218802706 0.2705229930520885 0.00021574414881456427 3.541821623754736e-05 0.26195976342360194 0.08731092057075601 6.437521667173008e-11 10.191281296215942 0.6997391946768926 DIDAATEAK(ub)HR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIDAATEAKHR 11 1 Q96SU4-3;Q96SU4-7;Q96SU4-2;Q96SU4;Q96SU4-6;Q96SU4-5;Q96SU4-4;A0A096LPC8 Q96SU4-3 OSBPL9 Oxysterol-binding protein-related protein 9 1 4751620.0 674120.0 916600.0 3160900.0 True False 872661.628891806 865590.4042438441 2585648.633572858 1.0 0.9918969456042869 2.962945256177215 19.735062837398257 -6.905974502238786 0.9227202871870706 0.9309345209313208 3.196893103668477 0.9893115336860359 0.09586450900372753 0.10714030321841385 0.15365526790915301 0.0769557559164154 0.2069481940900669 1.2417252080891005e-07 6.905974502238786 2.2659585827371562 up DIDAFWLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIDAFWLQR 9 0 O75643;A0A494C1A5;O75643-2 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 5327900.0 1134600.0 1567300.0 2626000.0 False True 1487471.5874820303 1333464.9492875494 2354286.710370698 1.0 0.8964641479605127 1.5827439866303594 20.504430680776515 -6.8684613338623715 1.1421309818053367 0.9419487600818918 1.6217903190599507 0.9631271126016335 0.05800703250834745 0.13834262722611912 0.3382328996305516 0.039449823333813056 0.09316262828884143 1.3537506125283697e-07 6.8684613338623715 0.679841558978059 DIDAFWLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIDAFWLQR 9 0 O75643;A0A494C1A5;O75643-2 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 4766600.0 1134600.0 1953300.0 1678700.0 False True 1554092.281412107 1866996.7473006817 1282225.633911742 1.0 1.2013422688157605 0.8250640256360215 20.567640742299407 -6.761376834636469 1.6074925092797725 1.1167531831027322 0.8236054161392891 0.6964649866353595 0.08470207752056204 0.2806211362456406 1.429505768532481 0.04156996438551071 0.09975564656913383 1.7323002392416679e-07 6.761376834636469 -0.29314776696344313 DIDEVSSLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIDEVSSLLR 10 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 16014700.0 1564200.0 6231100.0 8219400.0 False True 2050681.3477343458 5301444.168637559 7368935.334052132 1.0 2.585211093129975 3.593408279737636 20.96767190036231 -8.398696436010326 0.21510021342431188 1.0789128530469153e-14 4.65950013534874 0.9996381088381475 0.020306643187173862 0.12362227521920802 0.052991389998835646 0.48110207062632065 0.44089623689577695 3.993039110531381e-09 8.398696436010326 4.659500135348729 DIDEVSSLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIDEVSSLLR 10 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 16439800.0 1564200.0 8375300.0 6500300.0 False True 2142527.010915578 8005251.552586598 4965063.017880793 1.0 3.736359687323461 2.317386428542175 21.0308819618852 -9.895336954450555 10.121537173229175 1.0000235287138528 3.026873057932818 0.7312165163082689 0.5792934072706715 0.0 0.0 0.5608984213019562 0.1869661432199324 1.272515396104957e-10 9.895336954450555 2.026849529218965 DIDFLAEK(ub)DHTTLLSEVMTPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIDFLAEKDHTTLLSEVMTPR 21 1 A0A3B3IRL5;C9J029;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 1 28231400.0 6013800.0 8451600.0 13766000.0 True False 7784982.649720455 7981261.030446515 11260729.251087982 1.0 1.0252124365021043 1.446468124304983 22.892262393318255 -6.919161209630929 0.8309084524352591 0.9904215922011214 1.5131093979347663 0.9939451511191643 0.015934783510859567 0.09866766946959611 0.10818466235633172 0.013668871462204525 0.040623099006953954 1.2045887153745232e-07 6.919161209630929 0.5226878057336449 DIDIHEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIDIHEVR 8 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 25059000.0 7016200.0 2123800.0 15919000.0 False True 6793474.571473703 2971844.4154706914 11749336.340236716 1.0 0.43745573553034023 1.729503248539862 22.695718209318915 -6.78835099050353 1.5027741845024503 0.6849233590290279 1.7426578476529175 0.7959965324530538 0.23890592415438724 0.23780865263757914 1.0609655786010612 0.12514212487877655 0.29336189389367406 1.627979791164244e-07 6.78835099050353 1.0577344886238897 DIDILNSAGK(ub)MDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIDILNSAGKMDK 13 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 1 7511200.0 2665500.0 4845700.0 0.0 True False 3494496.312738722 4122740.44839066 0.0 1.0 1.179781026914167 0.0 21.736653093742795 -6.9236341521751 1.252187673221542 1.0951635462345675 1.619735598777241e-18 0.9610325065506029 0.10245062347887224 0.12029314052903549 0.3771856993524049 0.06738592339298408 0.13112991097463558 1.1922459280192785e-07 6.9236341521751 -1.0951635462345675 down DIDILNSAGK(ub)MDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIDILNSAGKMDK 13 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 1 5960700.0 2313700.0 1061400.0 2585600.0 True False 2240252.8599553513 1485222.5551278784 1908353.7936626691 1.0 0.6629709447876697 0.8518474980099804 21.095230149470964 -10.140026321231595 5.161668568021873 1.0000088302881969 0.7574092228060215 0.6874547496245351 0.07710852996260581 7.835867799327357e-06 1.3054835152165745e-06 0.07466272966599974 0.024886671032847602 7.243920556054202e-11 10.140026321231595 -0.24259960748217535 DIDILNSAGK(ub)MDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIDILNSAGKMDK 13 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 1 6454000.0 2665500.0 2044400.0 1744100.0 True False 3651007.382429027 1954071.6480732693 1332179.5008670206 1.0 0.5352143787705023 0.36487998005107214 21.799863155265687 -13.999999999999991 0.13955467740146593 3.2193424939422375 0.1529470072209946 0.999604715015342 0.005336552910721273 11.933606520330294 0.11701058846396663 7.214104093054419 0.18940976394207062 1.0000000000000205e-14 13.999999999999991 -3.066395486721243 DIDISSPEFK(ub)IK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIDISSPEFKIK 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 28933700.0 6278700.0 11159000.0 11496000.0 True False 8231436.503017289 9494120.697441323 10306504.197418703 1.0 1.1533977931994237 1.2520905911915599 22.972712792794155 DIDISSPEFK(ub)IK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIDISSPEFKIK 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 69486000.0 22947000.0 14184000.0 32355000.0 True False 22218560.045552734 19847745.16858283 23880254.870805852 1.0 0.8932957458940078 1.0747885921430684 24.40526198487842 -6.747353855320122 1.6596072783814304 0.9370609311534516 1.075079513694901 0.6376134477532014 0.04483289473362784 0.30463549317787364 1.6499941014642618 0.021347758555059083 0.05197202188245864 1.78914749484593e-07 6.747353855320122 0.13801858254144939 DIDISSPEFK(ub)IK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIDISSPEFKIK 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 177218000.0 36188000.0 34940000.0 106090000.0 True False 54899841.69717701 28704684.01253398 85121264.99910124 1.0 0.5228554969405312 1.5504828860641002 25.710298653459734 -6.780458297265967 1.5342001125397449 0.7299912942986649 1.5587242229489968 0.7689768368221019 0.20181626040331965 0.24985985574358233 1.161683980741951 0.10360714689803804 0.2443641045176278 1.6578365214554912e-07 6.780458297265967 0.8287329286503319 DIDISSPEFK(ub)IK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIDISSPEFKIK 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 32318700.0 6278700.0 10340000.0 15700000.0 True False 8600105.065487562 9883144.610192511 11991983.351649703 1.0 1.149188822105653 1.3943996335316686 23.035922854317047 -6.9636934988332415 0.3798142984026616 0.9831211712933305 1.5691359227080945 0.9998836183164197 0.001754080189985906 0.078407225243377 0.016441128962626457 0.0031917907729632935 0.020721917773719116 1.0871926337128274e-07 6.9636934988332415 0.586014751414764 DIDISSPEFK(ub)IK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIDISSPEFKIK 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 56217000.0 22947000.0 18393000.0 14877000.0 True False 19081447.224464267 18293913.258275334 17987711.916523878 1.0 0.9587277654087349 0.9426806942327668 24.185667260312695 -13.999999999991028 0.1306817068582948 1.196156337963805 0.9204012266520344 0.9996424841425092 0.0004564810323840227 11.93583018115329 0.11248546329216232 0.6010155343262714 0.019819128852640807 1.0000000000206596e-14 13.999999999991028 -0.27575511131177055 DIDISSPEFK(ub)IK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIDISSPEFKIK 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 164407000.0 36188000.0 32377000.0 95842000.0 True False 46846079.37212467 30575191.4883296 78399739.42196526 1.0 0.6526734338951551 1.6735603165249364 25.481424975552184 -6.814902525216779 1.3938484443536348 0.8117769575596447 1.6934911201036722 0.8722409249512414 0.15148387671636346 0.20018895621167665 0.7655622237510044 0.08543367258112762 0.19722194245411445 1.531431143617153e-07 6.814902525216779 0.8817141625440275 DIDISSPEFKIK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIDISSPEFKIK 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 11821200.0 3309000.0 2483900.0 6028300.0 True False 3203957.6062550237 3475734.223367383 4449307.384876495 1.0 1.0848252850105677 1.3886910913522075 21.61142362791653 -6.947411609971545 0.5865809172124226 0.9964502907109202 1.4922664237704832 0.9989821179365087 0.005323863001242739 0.08454223350244522 0.040395768415457986 0.005539085378934987 0.02543067821806201 1.1287256386717715e-07 6.947411609971545 0.49581613305956307 DIDISSPEFKIK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIDISSPEFKIK 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 32533600.0 7662000.0 4900600.0 19971000.0 True False 11623814.167231409 4026049.641437437 16023723.096399743 1.0 0.3463621822849885 1.3785254018919262 23.470580207759763 -6.735592604460375 1.703026842202106 0.609112972735178 1.3785461641282253 0.5849276555996146 0.2746736516446536 0.32584181301428194 1.853832520297781 0.12769077894931738 0.31484695402265034 1.838261940120928e-07 6.735592604460375 0.7694331913930473 DIDISSPEFKIK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIDISSPEFKIK 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 8849300.0 3309000.0 3502800.0 2037500.0 True False 2751580.1135552484 3483929.72114864 2463531.8296644054 1.0 1.2661560184948206 0.8953153199240625 21.391828903350806 -6.714080915864798 1.7807349880624705 1.1629403436387276 0.8960801527786213 0.48443908339991293 0.11208786114582024 0.3669241834044848 2.270525124979804 0.050045265031999284 0.1265096519182971 1.931608394587609e-07 6.714080915864798 -0.26686019086010626 DIDISSPEFKIK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIDISSPEFKIK 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 34840000.0 7662000.0 8327000.0 18851000.0 True False 9918610.040599626 7863595.1299787145 15420311.42759404 1.0 0.7928122083427855 1.5546847153456405 23.241706529852213 -6.834246415420268 1.308700150639727 0.8895714109536643 1.5770417411416124 0.9141232457487044 0.09425479172538791 0.1756304538176058 0.5867499782140561 0.056519769758093426 0.13008772817872347 1.4647165360019442e-07 6.834246415420268 0.6874703301879481 DIDLNK(ub)VK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIDLNKVK 8 1 Q9H9T3-2;Q9H9T3;E5RHY2;E5RIC0;E5RIZ7;E5RHR2 Q9H9T3-2 ELP3 Elongator complex protein 3 1 16552300.0 6118700.0 4142400.0 6291200.0 True False 9282515.236888401 3403156.3552810736 5047741.562469087 1.0 0.36662006669884534 0.5437902802905761 23.146084347534035 -10.844550636664835 10.972547968269739 1.0107289538927693 0.4552051734951684 0.926510219831287 0.07232943681994154 0.01803272331143918 0.0002554712275435303 0.06652423821983783 0.023344225353682923 1.4303731964058627e-11 10.844550636664835 -0.5555237803976009 DIDLNK(ub)VK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIDLNKVK 8 1 Q9H9T3-2;Q9H9T3;E5RHY2;E5RIC0;E5RIZ7;E5RHR2 Q9H9T3-2 ELP3 Elongator complex protein 3 1 14468000.0 6118700.0 2788300.0 5561000.0 True False 7920777.76760859 2633128.6538873115 4548955.060678497 1.0 0.3324330932064889 0.5743066140904871 22.917210669626485 -10.230432505777348 5.493981314744936 1.0000323373290156 0.45336985364855453 0.8719595740315897 0.0987444514094921 3.9113876971565696e-05 5.478981830617486e-06 0.09561454380971365 0.03186963465326119 5.882575288425594e-11 10.230432505777348 -0.5466624836804611 DIDPEGK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIDPEGKK 8 1 C9JLU1;P52434;P52434-4;P52434-2 C9JLU1 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 1 15625600.0 3638900.0 5347300.0 6639400.0 True False 4770633.13915773 4549503.683612149 5952418.577621938 1.0 0.9536477760717895 1.2477208798060828 22.185749316919157 -6.866586314831958 1.1519344436139418 0.9742528190515277 1.2638665817941606 0.9611594154175238 0.025442356348323068 0.1401736571806676 0.34977283096265227 0.01717350027188184 0.04043678098062235 1.3596079181016602e-07 6.866586314831958 0.28961376274263284 DIDPEGK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIDPEGKK 8 1 C9JLU1;P52434;P52434-4;P52434-2 C9JLU1 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 1 22475300.0 3103600.0 2925700.0 16446000.0 True False 4708388.103552526 2403585.976401564 13195440.89146214 1.0 0.5104901982459845 2.8025389159203016 22.166801813233576 -6.8508524767772565 1.2309560426031112 0.7385792894941678 2.895695000740372 0.94154374729801 0.23829006413412324 0.15651609275807596 0.45594752216703505 0.15144416107908332 0.350649892121728 1.4097675936833728e-07 6.8508524767772565 2.1571157112462043 up DIDPEGK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIDPEGKK 8 1 C9JLU1;P52434;P52434-4;P52434-2 C9JLU1 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 1 16949600.0 3638900.0 3962600.0 9348100.0 True False 4984299.667574931 3787519.2294341316 7140271.310162828 1.0 0.7598899508538012 1.4325525723530317 22.24895937844205 -6.810194129763599 1.4137894565425104 0.8691738000030379 1.4443650426244996 0.860319797812822 0.10402412459480034 0.20653392723901906 0.8136087039243064 0.057855403420260805 0.13381518532906203 1.548124452130444e-07 6.810194129763599 0.5751912426214617 DIDPEGK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIDPEGKK 8 1 C9JLU1;P52434;P52434-4;P52434-2 C9JLU1 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 1 15435000.0 3103600.0 2137400.0 10194000.0 True False 4017671.3811021983 2018451.8110743966 8338796.599272905 1.0 0.5023934562116077 2.075529780383696 21.937928135326025 -6.821647400590382 1.3646991583732309 0.7322301942523529 2.111111117364937 0.8881380281580783 0.21957727852130224 0.19134858142420197 0.6997859372035241 0.12642217234068417 0.29126720978317544 1.5078307623014297e-07 6.821647400590382 1.3788809231125843 up DIDTQAK(ub)YQSYFSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIDTQAKYQSYFSR 14 1 A0A590UJD8;Q5VVJ2;Q5VVJ2-3;Q5VVJ2-2 A0A590UJD8 MYSM1 Histone H2A deubiquitinase MYSM1 1 61193900.0 23352300.0 30168300.0 7673300.0 True False 30615091.443994876 25667307.235112347 6879340.523491045 1.0 0.8383874104072606 0.22470422915690563 24.867739656485128 -6.946071356615298 0.600434999086772 1.006905694898367 0.024748171319517363 0.9988557390232423 0.011297096016086312 0.08510285621414355 0.04279549257262544 0.011589712839300432 0.051579604749903044 1.1322143198420663e-07 6.946071356615298 -0.9821575235788497 down DIDTQAK(ub)YQSYFSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIDTQAKYQSYFSR 14 1 A0A590UJD8;Q5VVJ2;Q5VVJ2-3;Q5VVJ2-2 A0A590UJD8 MYSM1 Histone H2A deubiquitinase MYSM1 1 102114900.0 31982300.0 40150600.0 29982000.0 True False 30967039.39272592 56182943.96261293 22128814.75927991 1.0 1.814282058097235 0.7145925213786474 24.88423012479587 -6.7083875183175845 1.8012314333771255 1.5014253552935817 0.7173213996065737 0.4573712456507212 0.34322072870437204 0.37829348927555584 2.3915543657083744 0.15170415548279537 0.3861151136868872 1.9570975879229862e-07 6.7083875183175845 -0.784103955687008 DIDTQAK(ub)YQSYFSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIDTQAKYQSYFSR 14 1 A0A590UJD8;Q5VVJ2;Q5VVJ2-3;Q5VVJ2-2 A0A590UJD8 MYSM1 Histone H2A deubiquitinase MYSM1 1 172016000.0 78730000.0 55013000.0 38273000.0 True False 119439165.93397662 45195500.33146919 30708324.774348155 1.0 0.3783976552251904 0.2571043135994691 26.831700755110003 -13.999999999999995 0.2297485668961966 4.919431354878119 0.19798919296607748 0.999509451538974 0.0072071739019054755 13.283437213900037 0.1517693459929695 23.746642847098585 0.06306064777778395 1.0000000000000123e-14 13.999999999999995 -4.721442161912042 DIDTQAK(ub)YQSYFSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIDTQAKYQSYFSR 14 1 A0A590UJD8;Q5VVJ2;Q5VVJ2-3;Q5VVJ2-2 A0A590UJD8 MYSM1 Histone H2A deubiquitinase MYSM1 1 101074900.0 23352300.0 35561600.0 42161000.0 True False 31986276.382178668 33990370.92551472 32203440.133051116 1.0 1.062654824818954 1.0067892788856612 24.93094971800802 -6.618575721070518 2.121519365490223 1.0416133237659377 1.0069987244602034 0.07816596411793264 0.026953198866673803 0.5892447623572168 5.037352027580555 0.010445200763572427 0.029898510811560426 2.406712861951331e-07 6.618575721070518 -0.034614599305734295 DIDTQAK(ub)YQSYFSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIDTQAKYQSYFSR 14 1 A0A590UJD8;Q5VVJ2;Q5VVJ2-3;Q5VVJ2-2 A0A590UJD8 MYSM1 Histone H2A deubiquitinase MYSM1 1 88885900.0 31982300.0 36311100.0 20592500.0 True False 26594699.5061221 36115484.89711095 24898296.5410377 1.0 1.3579955994162356 0.9362127417648058 24.664635400230146 -6.681792016306317 1.8953101723586976 1.2261382333981807 0.9377863097158098 0.3324538758796167 0.1516671702476395 0.4345452731706561 3.019457985668205 0.06417147308301753 0.1688734154432535 2.0806928926871006e-07 6.681792016306317 -0.28835192368237095 DIDTQAK(ub)YQSYFSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIDTQAKYQSYFSR 14 1 A0A590UJD8;Q5VVJ2;Q5VVJ2-3;Q5VVJ2-2 A0A590UJD8 MYSM1 Histone H2A deubiquitinase MYSM1 1 181189100.0 78730000.0 72473000.0 29986100.0 True False 101917537.00031435 68439813.84111288 24528937.483368397 1.0 0.6715214658386199 0.2406743550257964 26.602827077202452 -7.2952907671636655 0.38255892146568365 1.0371579396225707 3.9808066979114457e-23 0.9995869425750787 0.006319301372043668 0.10173430079531354 0.029782862619759685 0.011699979418907127 0.05114417123995098 5.066513834188226e-08 7.2952907671636655 -1.0371579396225707 down DIEDVFYK(ub)YGAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIEDVFYKYGAIR 13 1 J3KTL2;Q07955;Q07955-3;Q07955-2;J3QQV5;J3KSW7 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 1 52716300.0 17570000.0 26897000.0 8249300.0 True False 23034440.148122046 22884072.443684824 7395741.568873191 1.0 0.9934720486597335 0.32107320695945596 24.4572891978887 -6.909023847357653 0.9023493664778814 1.021467382016845 0.2359651706899764 0.990548013197569 0.03096709814003732 0.10506759125623309 0.14229254726513393 0.025231371158409215 0.06918846411631933 1.233037124598329e-07 6.909023847357653 -0.7855022113268686 down DIEDVFYK(ub)YGAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIEDVFYKYGAIR 13 1 J3KTL2;Q07955;Q07955-3;Q07955-2;J3QQV5;J3KSW7 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 1 115071100.0 53393000.0 46293000.0 15385100.0 True False 51698068.4408506 64778036.31480587 11355280.766893383 1.0 1.2530068969389152 0.21964613203847877 25.6236070433424 -6.841966360679673 1.273177786664938 1.1345824754363298 0.18430296878115487 0.9277858528026702 0.11818550558985369 0.1665191703281472 0.5234703350322917 0.07276227158106971 0.16773410877106415 1.4389100281655316e-07 6.841966360679673 -0.950279506655175 down DIEDVFYK(ub)YGAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIEDVFYKYGAIR 13 1 J3KTL2;Q07955;Q07955-3;Q07955-2;J3QQV5;J3KSW7 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 1 93201500.0 41569000.0 34191000.0 17441500.0 True False 63063212.10097138 28089348.91449767 13994179.880118966 1.0 0.4454157658433799 0.22190718509093213 25.910295319233143 -11.138232593816486 0.17461040376525744 2.056436846743974 3.5723358897243373e-13 0.9995075630600001 0.007258642042888179 3.4070013775851953 0.10148630017116107 1.589079824748491 0.16751127104069488 7.273901340072005e-12 11.138232593816486 -2.056436846743617 DIEDVFYK(ub)YGAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIEDVFYKYGAIR 13 1 J3KTL2;Q07955;Q07955-3;Q07955-2;J3QQV5;J3KSW7 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 1 53659900.0 17570000.0 24005000.0 12084900.0 True False 24066103.811396725 22944379.7260804 9230695.516328102 1.0 0.9533898758973556 0.3835558754615203 24.52049925941159 -6.923127025026598 0.80119474185107 1.01121320627453 0.28471437572467906 0.9950063242402614 0.019804495652590754 0.09636674747753363 0.09633556176092209 0.017352483846873636 0.05363990123572653 1.1936389308066095e-07 6.923127025026598 -0.726498830549851 down DIEDVFYK(ub)YGAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIEDVFYKYGAIR 13 1 J3KTL2;Q07955;Q07955-3;Q07955-2;J3QQV5;J3KSW7 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 1 118029300.0 53393000.0 50401000.0 14235300.0 True False 44398645.21095663 50129479.80918483 17211835.413409464 1.0 1.1290767898659653 0.3876657797018084 25.404012318776676 -6.861994516957232 1.1756601643668418 1.0704349585232285 0.3503792387463378 0.9560134405383145 0.06782718016456028 0.1447627539621749 0.37908448831272923 0.044960502231360035 0.10519506282434257 1.374059322639038e-07 6.861994516957232 -0.7200557197768906 down DIEDVFYK(ub)YGAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIEDVFYKYGAIR 13 1 J3KTL2;Q07955;Q07955-3;Q07955-2;J3QQV5;J3KSW7 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 1 108215200.0 41569000.0 50836000.0 15810200.0 True False 53811889.94749231 48006931.911564514 12932905.826351246 1.0 0.8921249924209675 0.24033546933532174 25.681421641325592 -6.935687471733435 0.6985339773102779 1.0081390868630595 0.0848346227560482 0.9975426602741412 0.01663548111343166 0.08979039122991159 0.06398937388882811 0.015706128349093487 0.057244510516059964 1.1596115390213107e-07 6.935687471733435 -0.9233044641070114 down DIEK(ub)ACQSIYPLHDVFVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIEKACQSIYPLHDVFVR 18 1 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 9567500.0 1515300.0 3249100.0 4803100.0 True False 1986572.974186074 2764346.9448926016 4306121.286588529 1.0 1.3915154292407468 2.167612940749285 20.921850359257956 -6.960218391057633 0.4323445597968696 0.9699279620956468 2.6190779876889105 0.9997782143837022 0.007226096716093183 0.07962319025135031 0.020843702506034813 0.010143714093561339 0.06440581717365222 1.0959269553496041e-07 6.960218391057633 1.6491500255932636 up DIEK(ub)ACQSIYPLHDVFVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIEKACQSIYPLHDVFVR 18 1 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 37637700.0 6244200.0 7479500.0 23914000.0 True False 9472907.912167381 6144724.787399775 19187387.418121435 1.0 0.6486629918050026 2.025501313432635 23.175375929177218 -6.839023484614429 1.2868699466154634 0.8130629705045195 2.0699328342282994 0.9227702350967363 0.16232860526642381 0.1699425941749688 0.5470958206752381 0.09892614312120097 0.2278571789125861 1.4486935128568537e-07 6.839023484614429 1.25686986372378 up DIEK(ub)ACQSIYPLHDVFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIEKACQSIYPLHDVFVR 18 1 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 9716900.0 1515300.0 2806100.0 5395500.0 True False 2075547.3594427682 2682117.2234682012 4121194.023810566 1.0 1.292245735210919 1.985593826640989 20.985060420780847 -6.956573859021533 0.48129952206418436 0.9835595259486413 2.323250941555239 0.9996212548755541 0.008043861246844686 0.08094854237368938 0.025832194898745973 0.009801923440475195 0.05719286490248028 1.1051625020800484e-07 6.956573859021533 1.3396914156065978 DIEK(ub)ACQSIYPLHDVFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIEKACQSIYPLHDVFVR 18 1 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 38689800.0 6244200.0 5617600.0 26828000.0 True False 8083239.991583435 5304975.621732724 21945579.27852593 1.0 0.6562932224276972 2.7149483748319323 22.946502251269667 -6.863981284151282 1.1653652344986478 0.8111336882066381 2.822535668034318 0.9583036541715839 0.18386842533578732 0.14276171184641614 0.3661640395710078 0.12283818165518022 0.28816997114000514 1.3677877689129692e-07 6.863981284151282 2.0114019798276797 up DIEK(ub)SICR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIEKSICR 8 1 P50995-2;P50995;H0Y6E1 P50995-2 ANXA11 Annexin A11 1 3091000.0 841130.0 952970.0 1296900.0 True False 699436.8633770698 947836.1614602648 1568075.7938119133 1.0 1.3551418449463133 2.24191185211603 19.415834308804993 -6.955488068887489 0.494945616118392 0.9814356877795598 2.6535377875602997 0.999564532079718 0.010898522882596856 0.08135406428430876 0.027400364441994226 0.012906006462164913 0.07314111709770611 1.1079290024269289e-07 6.955488068887489 1.6721020997807399 up DIEK(ub)SICR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIEKSICR 8 1 P50995-2;P50995;H0Y6E1 P50995-2 ANXA11 Annexin A11 1 8594900.0 1423300.0 1799400.0 5372200.0 True False 1842489.9074374128 1699261.8082002767 4394514.723426908 1.0 0.9222638351184557 2.385095682580386 20.813225286050287 -6.894353109893019 0.9962574691316992 0.9294047398095672 2.5221988640430926 0.9835419874068149 0.08621169697665632 0.11568287358805796 0.20177635146903192 0.06552833464839294 0.16614563635054022 1.2754014021531865e-07 6.894353109893019 1.5927941242335253 up DIELVMSQANVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIELVMSQANVSR 13 0 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VZJ2 F8W0W4 NACA Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form 0 53003000.0 15919000.0 18659000.0 18425000.0 False True 20869963.1598153 15875149.932212336 16518557.745080011 1.0 0.760669763077475 0.791499132920664 24.314924718029904 -10.07177274387993 7.335028852584445 1.0000000347945617 0.776084448075002 0.9859818388249187 0.012586037534560111 7.166813994796212e-09 8.912418909059024e-10 0.012186380439022277 0.004062126147174398 8.476708643960747e-11 10.07177274387993 -0.2239155867195597 DIELVMSQANVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIELVMSQANVSR 13 0 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VZJ2 F8W0W4 NACA Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form 0 106396000.0 8581000.0 74901000.0 22914000.0 False True 13018004.35513088 61534331.34581598 18385037.856437013 1.0 4.7268636318717325 1.412277746641772 23.63400496619998 -6.617995491967031 2.123482125134552 3.4764120741084072 1.4246837068063727 0.07604129157125439 1.6035182682520102 0.5910585426222538 5.061311059448502 0.620981429406796 1.7790148327313882 2.4099304439468884e-07 6.617995491967031 -2.051728367302035 DIELVMSQANVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIELVMSQANVSR 13 0 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VZJ2 F8W0W4 NACA Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form 0 51412000.0 15919000.0 16129000.0 19364000.0 False True 21804684.494799342 15416367.448529521 14790622.01409837 1.0 0.7070208904974752 0.6783231382057419 24.378134779552795 -13.999999999999998 0.32848478685536553 4.160320986324885 0.6731501835956608 0.9997116868946421 0.0024679837432718425 18.696335336713936 0.18319578865159286 40.78888616215437 0.009248668927197052 1.0000000000000041e-14 13.999999999999998 -3.4871708027292243 DIELVMSQANVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIELVMSQANVSR 13 0 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VZJ2 F8W0W4 NACA Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form 0 32406800.0 15665000.0 7515000.0 9226800.0 False True 13026141.577166216 7474515.203389286 11156081.22009697 1.0 0.5738088411760788 0.8564378909908892 23.634906476296685 -9.890836659700854 5.290246032562205 1.0000003862868008 0.7151233660801836 0.5753037601585169 0.11538282643387254 5.256383471304335e-07 1.1045346314354566e-07 0.11171909112353112 0.03723964709972772 1.2857701535194966e-10 9.890836659700854 -0.2848770202066172 DIGEGNLSTAAAAALAAAAVK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIGEGNLSTAAAAALAAAAVKAK 23 1 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 20875400.0 12253000.0 4622100.0 4000300.0 True False 18588696.814289562 3797250.1423678664 3209638.951606228 1.0 0.20427737244328134 0.1726661628661835 24.147922295928655 DIGEGNLSTAAAAALAAAAVKAK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIGEGNLSTAAAAALAAAAVKAK 23 1 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 19487800.0 8701300.0 7756600.0 3029900.0 True False 7235516.482949019 7714813.656235455 3663438.0813252437 1.0 1.0662422889113625 0.5063132797718561 22.78666457167819 -6.877381530014641 1.0942414355341306 1.0397974337168032 0.4685625898075288 0.9715138211465228 0.042162171054091147 0.12997753365057813 0.28648508120721317 0.029746682149866283 0.07148355241994403 1.3262288467039665e-07 6.877381530014641 -0.5712348439092745 DIGRPK(ub)ELTIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIGRPKELTIR 11 2 Q8IZ07;H0YIN8;S4R3U2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 45280000.0 7701000.0 20656000.0 16923000.0 True False 11682980.018513335 16969775.413935356 13578161.63238559 1.0 1.4525211364775379 1.1622173119246177 23.47790497863246 -10.150558252857655 4.726629683999948 0.9999703130473611 1.3073692242013528 0.5991501697062275 0.11851604009743578 3.708824764074693e-05 6.665071085646894e-06 0.1147637350249899 0.03825088746176813 7.070363580056447e-11 10.150558252857655 0.30739891115399176 DIGRPK(ub)ELTIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIGRPKELTIR 11 2 Q8IZ07;H0YIN8;S4R3U2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 33298200.0 7701000.0 17874000.0 7723200.0 True False 9969096.309404569 16879296.18749123 6317656.846724001 1.0 1.6931621145607523 0.6337241261039979 23.24903130072491 -6.730193715155299 1.722736421779321 1.4170542867607199 0.6343553751061143 0.5600911311972241 0.2913835880210336 0.3358641130678169 1.9529243922728934 0.13403827990779227 0.33250697434247145 1.8612567460447873e-07 6.730193715155299 -0.7826989116546056 DIGTQTNLK(ub)CR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIGTQTNLKCR 11 1 A0A087WV20;A0A087WTU9;Q8TCU4-3;Q8TCU4-2;Q8TCU4;H7C1D9;A0A494BZW1 A0A087WV20 ALMS1 Alstrom syndrome protein 1 1 5277500.0 1203600.0 1726500.0 2347400.0 True False 1165392.3768173319 2415900.4535785615 1732545.519509495 1.0 2.0730360877907468 1.4866628218738218 20.152384348049967 -10.502123277622756 4.87429556740093 0.9970811453330879 1.7798494548323431 0.702236509913112 0.2393858833845002 0.007613365575066754 0.0007776534183099739 0.23240008203075502 0.07726146163874768 3.1468549298295506e-11 10.502123277622756 0.7827683094992552 DIGTQTNLK(ub)CR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIGTQTNLKCR 11 1 A0A087WV20;A0A087WTU9;Q8TCU4-3;Q8TCU4-2;Q8TCU4;H7C1D9;A0A494BZW1 A0A087WV20 ALMS1 Alstrom syndrome protein 1 1 3853400.0 1203600.0 1407800.0 1242000.0 True False 1000846.7285207316 1400215.9019735784 1501696.457640831 1.0 1.3990313022685514 1.5004260041498698 19.932789623484243 -12.136998811498653 0.22336575925305405 8.395344975455418e-14 1.5578913964881969 0.9993828707737344 0.00536607304452143 5.570649462069566 0.136510746184592 2.606396933466142 0.054722165094060166 7.294595065093122e-13 12.136998811498653 1.557891396488113 DIHLDLPSNNNLVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIHLDLPSNNNLVSK 15 0 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;P18583-6;H7C1M2;P18583-3 P18583-2;P18583-3 SON Protein SON 0 10128400.0 1771200.0 4858100.0 3499100.0 False True 2322060.352325197 4133290.4167254856 3137046.697737282 1.0 1.7800099005121086 1.3509755224906184 21.146974038887148 -10.104581191860888 4.358707564992905 0.9999318465533895 1.5654927115300101 0.6984658016205496 0.1751525515387145 25457239.678670872 19672106.927797806 15200.877636486824 0.05995937856444774 7.859932350579817e-11 10.104581191860888 0.5655608649766206 DIIALNPLYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIIALNPLYR 10 0 K7EJE8;K7EKE6;P36776-2;P36776;P36776-3 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 3789950.0 567450.0 1506000.0 1716500.0 False True 743932.4451936169 1281310.670342023 1538893.0458306542 1.0 1.7223481495131554 2.068592458593656 19.50481209387613 -10.030078223635927 0.17251258905949446 2.5206194881662317e-15 2.4740936570528933 0.9995952302404374 0.008956261536745174 1.589011566965474 0.08040755650678519 0.9822040164831405 0.2535992410948954 9.330862213633231e-11 10.030078223635927 2.4740936570528906 DIIALNPLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIIALNPLYR 10 0 K7EJE8;K7EKE6;P36776-2;P36776;P36776-3 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 2555950.0 567450.0 0.0 1988500.0 False True 777251.5997596508 0.0 1518857.2544430192 1.0 0.0 1.9541384731954168 19.56802215539902 -6.767608156305158 1.5836919171034065 0.4246753357214149 1.964130193880589 0.7213024506925889 0.4211978530365377 0.2703123805628684 1.3376290407263012 0.20968580819742316 0.5002257716855356 1.7076224023621954e-07 6.767608156305158 1.539454858159174 DIIFAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIIFAIK 7 0 P11177-2;P11177;P11177-3 P11177-2 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 16876900.0 6485700.0 5586000.0 4805200.0 False True 8502815.507608147 4752590.574057455 4308003.99873316 1.0 0.5589431606277866 0.5066561769896625 23.019509204255115 -13.999999999999998 0.3008687413783814 5.043335963555774 0.4939063452562813 0.9996517680684303 0.0041291539660517195 16.64539853136469 0.17422707456111744 41.91868605006303 0.018826012250767857 1.0000000000000041e-14 13.999999999999998 -4.549429618299492 DIIFAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIIFAIK 7 0 P11177-2;P11177;P11177-3 P11177-2 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 19105900.0 6679700.0 3283400.0 9142800.0 False True 6467656.579782916 4594478.7427047985 6748026.401879283 1.0 0.7103776593622121 1.0433495221395594 22.624811645817005 -6.676747100313238 1.913239998972143 0.8162214969235289 1.0420578242698868 0.30936391071121216 0.1228369058412697 0.44580630426493717 3.152101491231794 0.0515690255818434 0.13658952753445702 2.105003875206458e-07 6.676747100313238 0.22583632734635795 DIIFAIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIIFAIK 7 0 P11177-2;P11177;P11177-3 P11177-2 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 25841000.0 5937300.0 9713700.0 10190000.0 False True 9007318.174772007 7980214.341515487 8175942.033564346 1.0 0.8859700730753282 0.9076999252079041 23.10266619346696 -10.384360372627905 4.876179843640371 1.0001026972113738 0.896834999141706 0.9677971322800426 0.0088711749852563 9.914180023238533e-06 1.251713102149419e-06 0.00859801763529763 0.0028631594149182643 4.127049020272797e-11 10.384360372627905 -0.10326769806966785 DIIFAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIIFAIK 7 0 P11177-2;P11177;P11177-3 P11177-2 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 20686400.0 6485700.0 6063900.0 8136800.0 False True 8883638.559452234 5795976.847364253 6215055.422656258 1.0 0.6524327626091121 0.6996069663418948 23.082719265778007 -10.140381424742703 6.7375386220983415 1.000000523356416 0.6760198644758065 0.984347555921431 0.01925878802790302 1.5140959776309404e-07 1.932166025363524e-08 0.018647271611183083 0.006215747108350524 7.237999941420563e-11 10.140381424742703 -0.32398065888060945 DIIFAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIIFAIK 7 0 P11177-2;P11177;P11177-3 P11177-2 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 13079000.0 6679700.0 1939800.0 4459500.0 False True 5554466.510883947 1929349.9123798474 5391960.831601687 1.0 0.34735107477906235 0.9707432425843542 22.40521692125128 -10.910142675681184 10.652325175823854 1.0376274546602948 0.6590471586828773 0.28512476179350144 0.25449878679507204 0.13643743115588655 0.001150911505677749 0.1478318002174613 0.08213913024060884 1.2298646657346834e-11 10.910142675681184 -0.3785802959774175 DIIFAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIIFAIK 7 0 P11177-2;P11177;P11177-3 P11177-2 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 20005300.0 5937300.0 9093800.0 4974200.0 False True 7685951.891680009 8587722.035907343 4068946.639602047 1.0 1.117327060712349 0.5294004824576972 22.87379251555941 -6.854815152632952 1.2115170223292124 1.0629760823210765 0.5036060577971596 0.9470347324434494 0.058468268724332445 0.1522416355737253 0.42757580858582755 0.03770995578564621 0.08758176009624906 1.3969628193413985e-07 6.854815152632952 -0.5593700245239169 DIIHDPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIIHDPGR 8 0 P62917;E9PKZ0;E9PKU4;G3V1A1 P62917 RPL8 60S ribosomal protein L8 0 14033200.0 3611000.0 1612500.0 8809700.0 False True 3496370.781561463 2256379.659076413 6502175.284665069 1.0 0.6453490776709684 1.8596927187914627 21.73742675655263 -6.828538438421762 1.3344687955991812 0.810299754202643 1.8913961342552268 0.902913808136341 0.1588609239596639 0.1826204311437297 0.6365495280208068 0.09348390306244078 0.2151445835026437 1.4840945204040685e-07 6.828538438421762 1.0810963800525837 DIIHFFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIIHFFR 7 0 F8W7U8;P49959-2;P49959;P49959-3 F8W7U8 MRE11A Double-strand break repair protein MRE11A 0 8721300.0 2082000.0 1784900.0 4854400.0 False True 2729522.162116683 1518599.8774857074 4352113.254692882 1.0 0.5563610724845947 1.5944597611612417 21.380216980292378 -6.790573583805927 1.4939440475069103 0.7522334158645604 1.6056895470693333 0.8031980749939269 0.18866884046214266 0.23450251950652806 1.0339250527035933 0.09939872679299182 0.2326295725131784 1.6196695452250186e-07 6.790573583805927 0.8534561312047729 DIIHFFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIIHFFR 7 0 F8W7U8;P49959-2;P49959;P49959-3 F8W7U8 MRE11A Double-strand break repair protein MRE11A 0 8610910.0 2172500.0 899410.0 5539000.0 False True 2103535.176666379 1258549.1033611887 4088169.733561852 1.0 0.5983019049653833 1.9434758110585362 21.004384513305755 -6.826665107309696 1.342713704091077 0.7848157288236581 1.9772775951139934 0.8990475378111369 0.17914149439968494 0.18496034200934672 0.6533202733265548 0.10478780526976426 0.24120942797699144 1.4905099951304058e-07 6.826665107309696 1.1924618662903352 DIIHFFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIIHFFR 7 0 F8W7U8;P49959-2;P49959;P49959-3 F8W7U8 MRE11A Double-strand break repair protein MRE11A 0 9128000.0 2082000.0 2810700.0 4235300.0 False True 2851771.663934434 2686513.980258038 3235009.368741523 1.0 0.9420508711246541 1.1343858309744046 21.44342704181527 -6.8259012027275014 1.3460255126006744 0.968937276061798 1.139144886557455 0.8974464319580742 0.025798780384914264 0.18592246684279312 0.660200878107134 0.015054494267699977 0.034658104957985686 1.493134042705805e-07 6.8259012027275014 0.1702076104956569 DIIHFFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIIHFFR 7 0 F8W7U8;P49959-2;P49959;P49959-3 F8W7U8 MRE11A Double-strand break repair protein MRE11A 0 4978200.0 2172500.0 1491000.0 1314700.0 False True 1806530.0080685355 1482967.6870596723 1589597.691514012 1.0 0.8208929164953079 0.879917678872958 20.78478978874003 -10.210681002335708 7.19617192042351 1.0000003124935133 0.850405297684133 0.8954468399822242 0.024096758335711385 1.20790806953128e-07 1.3286094817982001e-08 0.02333163460588907 0.007777195310982912 6.156288979654848e-11 10.210681002335708 -0.1495950148093803 DIILQSNPLLEAFGNAK(ub)TVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIILQSNPLLEAFGNAKTVR 20 1 O00160;Q12965 O00160 MYO1F;MYO1E Unconventional myosin-If;Unconventional myosin-Ie 1 5569100.0 1455500.0 2120400.0 1993200.0 True False 1409295.949200419 2967086.7777399225 1471121.125281728 1.0 2.105368130393999 1.0438695478521642 20.426543175726756 -6.636721065075299 2.0564884100278182 1.7246405711406965 1.0482653750194972 0.1421161643791693 0.4733441782691495 0.5416632540854012 4.374088785054677 0.1877128245031119 0.5241059358366618 2.3082292223482968e-07 6.636721065075299 -0.6763751961211992 DIILQSNPLLEAFGNAK(ub)TVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIILQSNPLLEAFGNAKTVR 20 1 O00160;Q12965 O00160 MYO1F;MYO1E Unconventional myosin-If;Unconventional myosin-Ie 1 6181100.0 1455500.0 1931300.0 2794300.0 True False 1210312.7395828539 1920895.7035669654 3378575.2106165653 1.0 1.5871069028233322 2.791489422627266 20.206948451161033 -6.959545559639257 0.4417910636246188 0.9577318090041074 3.467961618058841 0.999752973786056 0.01172027409583622 0.07986385170698122 0.021734091013003533 0.015915093689186314 0.09975745495150123 1.0976261378228574e-07 6.959545559639257 2.5102298090547333 DIINEEEVQFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIINEEEVQFLK 12 0 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 29280600.0 13057000.0 4318600.0 11905000.0 False True 12642512.682040455 6043039.501201493 8786723.357655516 1.0 0.4779935486864126 0.695014003833087 23.591779889883195 -10.256473379263685 5.596036236269736 1.000028554176222 0.5865037762597395 0.8287786017713199 0.08859822980935914 3.15650219126578e-05 4.194068894122609e-06 0.08579077919766015 0.02859495571291968 5.540215024827147e-11 10.256473379263685 -0.41352477791648246 DIISDTSGDFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIISDTSGDFR 11 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 17434800.0 2520200.0 6958400.0 7956200.0 False True 3304006.6056515183 5920233.843630758 7132968.7452594545 1.0 1.7918347480008578 2.1588845291829863 21.655785140443264 -9.98813204279811 0.1844734698777182 1.8009266436579414e-20 2.541899501002594 0.9995229647483121 0.010562172704144201 1.5191007958696299 0.0847312794114571 1.0013728052884088 0.24517313146343422 1.0277037877890234e-10 9.98813204279811 2.541899501002594 DIISDTSGDFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIISDTSGDFR 11 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 20200100.0 4429200.0 1421900.0 14349000.0 False True 4288597.470421507 1989672.085110545 10590566.439227114 1.0 0.46394470426131856 2.469470849682289 22.032074479683395 -6.835580779141179 1.3027402670427373 0.7144764106780583 2.529876382927275 0.9165897852703683 0.24485072874458272 0.1740235660989177 0.5755971452238569 0.1474757358577994 0.3394619710082842 1.460223121444515e-07 6.835580779141179 1.8153999722492167 up DIISDTSGDFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIISDTSGDFR 11 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 15860800.0 2520200.0 6524400.0 6816200.0 False True 3451986.0458441675 6236130.434694392 5206353.94404552 1.0 1.8065340797660654 1.5082198696351712 21.718995201966155 -10.081426845737488 4.37493246008716 0.9999390448691619 1.6573769747515847 0.8662154138343547 0.12178626652277971 15883159.905434815 9150140.745930424 8856.301764588754 0.041690679192479214 8.290355505057701e-11 10.081426845737488 0.6574379298824229 DIISIAEDEDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIISIAEDEDLR 12 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 6100900.0 0.0 3580900.0 2520000.0 False True 0.0 3046643.678238872 2259254.573546896 0.0 DIISIAEDEDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIISIAEDEDLR 12 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 7182200.0 0.0 2766900.0 4415300.0 False True 0.0 2644649.2090852708 3372497.07595789 0.0 DIK(ub)AANVLLSEQGDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIKAANVLLSEQGDVK 16 1 Q8NBY1;B4E0Y9;Q9P289;Q9P289-2;Q9P289-3;C9JDH9;C9J6L2;C9JCC0;C9J232;H7C279;O00506-3;O00506-2;O00506;C9JJV0 Q8NBY1 STK26;STK25 Serine/threonine-protein kinase 26;Serine/threonine-protein kinase 25 1 5655200.0 0.0 1762900.0 3892300.0 True False 0.0 2466835.163402052 2872789.863502942 0.0 DIK(ub)AANVLLSEQGDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIKAANVLLSEQGDVK 16 1 Q8NBY1;B4E0Y9;Q9P289;Q9P289-2;Q9P289-3;C9JDH9;C9J6L2;C9JCC0;C9J232;H7C279;O00506-3;O00506-2;O00506;C9JJV0 Q8NBY1 STK26;STK25 Serine/threonine-protein kinase 26;Serine/threonine-protein kinase 25 1 4345200.0 0.0 2399300.0 1945900.0 True False 0.0 2386374.494676236 2352778.693174957 0.0 DIK(ub)DENILIDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIKDENILIDLR 12 1 Q9P1W9;C9J8V9 Q9P1W9 PIM2 Serine/threonine-protein kinase pim-2 1 8202200.0 1501900.0 1650500.0 5049800.0 True False 1969005.4444202902 1404251.8335986119 4527295.137102029 1.0 0.7131782380683301 2.299280151779847 20.90903566970904 -6.860103829003927 1.185289277424174 0.8443538693961378 2.3762115127757206 0.9537626987895464 0.14839077020398997 0.14668948395801906 0.39155475342277424 0.09764515036065789 0.22794766220234416 1.3800542885198914e-07 6.860103829003927 1.531857643379583 up DIK(ub)DENILIDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIKDENILIDLR 12 1 Q9P1W9;C9J8V9 Q9P1W9 PIM2 Serine/threonine-protein kinase pim-2 1 31955800.0 2642900.0 6609900.0 22703000.0 True False 2559002.5861503193 9249267.54017313 16756403.224599151 1.0 3.6144033578674217 6.548021215487298 21.287150174702454 -6.969632467441913 0.26681921004485154 0.24202266008819923 10.008222369122409 0.9999793722665484 0.010292660842259705 0.07642215395614795 0.009456088182029337 0.05864647484975043 0.2740559976891135 1.0724264890356706e-07 6.969632467441913 9.76619970903421 DIK(ub)DENILIDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIKDENILIDLR 12 1 Q9P1W9;C9J8V9 Q9P1W9 PIM2 Serine/threonine-protein kinase pim-2 1 117677300.0 4833300.0 29287000.0 83557000.0 True False 7332469.461560899 24060506.029624563 67041922.325665824 1.0 3.281364641988251 9.143157387442331 22.805867726749106 -6.954872231149718 0.5025207764134778 0.8851282242225363 11.793302734997777 0.9995302261849068 0.07433997734654348 0.08158636047606965 0.028307541169188735 0.086773821460028 0.48359078464732164 1.1095011810015005e-07 6.954872231149718 10.908174510775241 DIK(ub)DENILIDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIKDENILIDLR 12 1 Q9P1W9;C9J8V9 Q9P1W9 PIM2 Serine/threonine-protein kinase pim-2 1 24480600.0 2642900.0 6441700.0 15396000.0 True False 2197688.4503219007 6406997.28352266 18615232.41693902 1.0 2.915334647449329 8.470369134538794 21.06755545013673 -6.952208032965607 0.5340537403341623 0.9148607393493816 10.724775239699484 0.9993633613553664 0.07993725904872367 0.0826110439937299 0.032385390430181904 0.08865807728578702 0.45962392042396655 1.1163283832033706e-07 6.952208032965607 9.809914500350104 DIK(ub)DENILIDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIKDENILIDLR 12 1 Q9P1W9;C9J8V9 Q9P1W9 PIM2 Serine/threonine-protein kinase pim-2 1 93790300.0 4833300.0 22861000.0 66096000.0 True False 6256802.128586558 21588765.25356592 54067206.20223091 1.0 3.450447178907818 8.641348262430181 22.576994048841556 -6.958904965773605 0.4506011789380242 0.8336290609404855 11.464156245429896 0.9997274053346131 0.05259794196562814 0.08009462863882184 0.022594318680661227 0.06944403416139235 0.4293350660520292 1.0992463550326431e-07 6.958904965773605 10.630527184489411 DIK(ub)DTTVGTLSQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIKDTTVGTLSQR 13 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 71580000.0 15201800.0 30560000.0 25818200.0 True False 19929707.014440622 26000567.121946972 23146780.329662103 1.0 1.3046136153987382 1.161421003976148 24.248417165561587 -10.152930761785335 4.165856937456033 0.9999386475066571 1.2330173096749721 0.7792887260988882 0.05845813908762303 40905169.39240233 3.668028943031112 27058.482861427852 0.020011775863694327 7.031844174463222e-11 10.152930761785335 0.23307866216831508 DIK(ub)DTTVGTLSQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIKDTTVGTLSQR 13 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 93706500.0 27849900.0 25780600.0 40076000.0 True False 26965820.168764554 36074928.02405291 29578893.345770855 1.0 1.337801995202792 1.0969031596536831 24.68462857847591 -10.229102097079227 5.122931897923776 0.9999755763333962 1.2173525774282756 0.5204809208764847 0.09834653778799676 2.744312844772681e-05 4.1298481200149864e-06 0.09523432059987394 0.031741208584123985 5.900623477527412e-11 10.229102097079227 0.21737700109487945 DIK(ub)DTTVGTLSQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIKDTTVGTLSQR 13 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 141895000.0 54808000.0 40217000.0 46870000.0 True False 83147743.00151658 33039962.13314482 37606123.956149265 1.0 0.39736450973229887 0.45228075469785567 26.309173767114192 -10.676381196899898 10.397862491002254 1.0002482321186892 0.42482263327295344 0.9932095234059571 0.022419463125883308 0.00012906289682745534 4.0169052000801656e-06 0.02171615280113306 0.007235850609788117 2.1067781382791348e-11 10.676381196899898 -0.5754255988457357 DIK(ub)DTTVGTLSQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIKDTTVGTLSQR 13 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 68692400.0 15201800.0 20720600.0 32770000.0 True False 20822316.273198105 19805095.37813877 25030400.91933503 1.0 0.9511475629457865 1.2020949346328704 24.31162722708448 -6.856194001595258 1.2046522446154966 0.9737150487156152 1.2134018564627775 0.948856337413339 0.024566544596550683 0.15078208601178006 0.4179465391104933 0.01592713972254139 0.03703750069529639 1.3925346115615274e-07 6.856194001595258 0.23968680774716233 DIK(ub)DTTVGTLSQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIKDTTVGTLSQR 13 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 90828000.0 27849900.0 49282000.0 13696100.0 True False 23158425.809761986 49016508.084288865 16559891.186388556 1.0 2.1165734012726767 0.715069811843949 24.465033853910185 -6.694500813166021 1.8506376983285986 1.69706351459301 0.7196670545863535 0.3914404541019877 0.471812036431083 0.4070839475783637 2.706531216441176 0.20370236496188368 0.5274235947382304 2.0206876484855768e-07 6.694500813166021 -0.9773964600066565 DIK(ub)DTTVGTLSQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIKDTTVGTLSQR 13 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 115314400.0 54808000.0 50736000.0 9770400.0 True False 70950036.42719722 47912496.999471575 7992287.4527698625 1.0 0.6752991176915777 0.11264669977965205 26.08030008920664 -7.396305608034537 0.5500049077057138 1.006046463000055 7.420223365516876e-23 0.9967792709377189 0.020803747611588132 0.10897376084617628 0.06987303117453969 0.021016203744684485 0.06454865318046495 4.0150817472963866e-08 7.396305608034537 -1.006046463000055 down DIK(ub)GSYVSIHSSGFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIKGSYVSIHSSGFR 15 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8 O00148 DDX39A ATP-dependent RNA helicase DDX39A 1 16757100.0 5807300.0 7017200.0 3932600.0 True False 7613426.537973204 5970261.112831363 3525692.276162908 1.0 0.7841753096393214 0.4630887628031799 22.86011447597511 -6.965393635213779 0.35123366094005376 1.0305920215856206 0.20581693440909438 0.9999210277685413 0.0019603183348152575 0.07782766677613648 0.014390553934201866 0.004393779599652316 0.02757583509532447 1.0829449109895988e-07 6.965393635213779 -0.8247750871765263 down DIK(ub)GSYVSIHSSGFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIKGSYVSIHSSGFR 15 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8 O00148 DDX39A ATP-dependent RNA helicase DDX39A 1 21221100.0 7491400.0 7802000.0 5927700.0 True False 7253589.607585043 10917379.286892502 4375057.542811808 1.0 1.5051002162400051 0.6031575784542362 22.790263692375596 -6.754751837286251 1.6322996813404234 1.2953046344024364 0.6007018286312208 0.6691126348416827 0.2123164631614433 0.291845266262279 1.5312628753298663 0.10269229873014626 0.24807423601296744 1.7589284062756753e-07 6.754751837286251 -0.6946028057712156 DIK(ub)GSYVSIHSSGFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIKGSYVSIHSSGFR 15 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8 O00148 DDX39A ATP-dependent RNA helicase DDX39A 1 59346900.0 12983900.0 13681000.0 32682000.0 True False 19697525.550237015 11239518.659859106 26222388.374970544 1.0 0.5706056139484923 1.3312529184486839 24.231511070511424 -6.753544448257234 1.6367521903091158 0.7485948364404348 1.3331820729576052 0.6640967406052912 0.18047474641143985 0.293889463035633 1.5500731773056842 0.0870662796032794 0.21059077938540147 1.7638252349669018e-07 6.753544448257234 0.5845872365171704 DIK(ub)GSYVSIHSSGFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIKGSYVSIHSSGFR 15 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8 O00148 DDX39A ATP-dependent RNA helicase DDX39A 1 19197800.0 5807300.0 9380000.0 4010500.0 True False 7954415.746381572 8965560.584487993 3063302.4988401933 1.0 1.1271174238744543 0.3851071651910671 22.923324537498 -6.8627632274819295 1.1716175651675715 1.0695483183456562 0.34721873354003047 0.9569159377749139 0.06725339197234853 0.14398688117189995 0.3740020264290566 0.04471617488151337 0.10473290872390006 1.371629359417836e-07 6.8627632274819295 -0.7223295848056257 down DIK(ub)GSYVSIHSSGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIKGSYVSIHSSGFR 15 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8 O00148 DDX39A ATP-dependent RNA helicase DDX39A 1 23428700.0 7491400.0 12036000.0 3901300.0 True False 6229431.025290966 11971159.67904106 4717043.792426879 1.0 1.9217099652342498 0.7572190418797604 22.570668967809873 -6.695763880859259 1.8462079152133994 1.5747062827960132 0.760969015495838 0.39744130959558877 0.38937454291853013 0.4043758475708315 2.676611706189205 0.16845797523280578 0.43547192266640605 2.0148193780254907e-07 6.695763880859259 -0.8137372673001753 DIK(ub)GSYVSIHSSGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIKGSYVSIHSSGFR 15 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8 O00148 DDX39A ATP-dependent RNA helicase DDX39A 1 58289900.0 12983900.0 12586000.0 32720000.0 True False 16807914.50093208 11885578.036016839 26765295.735551294 1.0 0.7071417477378128 1.59242217314153 24.002637392603873 -6.817548511183104 1.3823864788174764 0.8417446958549858 1.6107601869633206 0.8786568061530244 0.12827638252473766 0.1966922180765725 0.7392218949138707 0.07293019634646596 0.16821714386048475 1.5221290998481734e-07 6.817548511183104 0.7690154911083348 DIK(ub)LENLIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIKLENLIIK 10 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 4810600.0 1096200.0 1477900.0 2236500.0 True False 1437128.8156158994 1257403.0808090807 2005088.4340228701 1.0 0.8749411097641968 1.3952043910298775 20.45475795145424 -6.843237269873722 1.2672888828485356 0.9334750094778428 1.4134416129480658 0.9298805346555303 0.05871576680983379 0.16504731018574986 0.5134969085136866 0.036309671026902184 0.08373681143207223 1.4347053907570862e-07 6.843237269873722 0.479966603470223 DIK(ub)LENLIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIKLENLIIK 10 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 6714100.0 1922400.0 1031400.0 3760300.0 True False 1861374.4642685575 1443243.3986799465 2775364.623418059 1.0 0.7753643484343603 1.4910297077212036 20.827936889846494 -6.822334488696171 1.361694199504929 0.8791998996108383 1.5074562205141928 0.8896801958512206 0.09925799713277172 0.1904638740955604 0.6932869974438748 0.05727104971868335 0.1319287735031699 1.505447141208637e-07 6.822334488696171 0.6282563209033545 DIK(ub)LENLIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIKLENLIIK 10 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 4888600.0 1096200.0 1280500.0 2511900.0 True False 1501494.7636911243 1223923.2759527597 1918640.954204386 1.0 0.8151365596134277 1.2778206095689548 20.517968012977132 -6.798308550489589 1.4631052330173553 0.8977824182035239 1.2839224528080535 0.8270819512117583 0.07907355158606397 0.22318626568116337 0.9434481483037153 0.04252323716490851 0.09898399742036687 1.5910779222013035e-07 6.798308550489589 0.3861400346045296 DIK(ub)LENLIIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIKLENLIIK 10 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 5598000.0 1922400.0 1443900.0 2231700.0 True False 1598560.77675993 1436121.424108291 2698338.1517850594 1.0 0.8983839995243209 1.687979707130205 20.60834216528077 -6.874560499251455 1.109640346033162 0.9405897366899122 1.7384238048526361 0.9690288395952017 0.06172364276256681 0.13255976472360426 0.30230539982803717 0.043037133489065287 0.10278381495219453 1.334871622752692e-07 6.874560499251455 0.797834068162724 DIK(ub)SDNVLLGMEGSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIKSDNVLLGMEGSVK 16 1 Q13177;H7C1X3 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 18818600.0 4818200.0 6171900.0 7828500.0 True False 6316706.859515177 5251076.577877778 7018481.916274554 1.0 0.831299709589628 1.1110982466603239 22.590741191702907 -6.743511888088471 1.6744373833189288 0.9000308143826495 1.1113714159983767 0.6203528384474167 0.07087713598223123 0.3114978208115535 1.7162352558843772 0.03347290880781873 0.08180597204922684 1.8050453263443576e-07 6.743511888088471 0.2113406016157272 DIK(ub)SDNVLLGMEGSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIKSDNVLLGMEGSVK 16 1 Q13177;H7C1X3 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 37362500.0 11600600.0 11253800.0 14508100.0 True False 11232345.302847395 15747501.027791724 10707993.37632944 1.0 1.4019780022075834 0.9533176810024678 23.42115585673376 -6.6705432274472045 1.9355729963462232 1.2564652019605866 0.955132764507748 0.28137751683105183 0.17073094492629193 0.45988627271854315 3.322221340894433 0.07100038930582499 0.1895522952992086 2.1352895396911487e-07 6.6705432274472045 -0.30133243745283866 DIK(ub)SDNVLLGMEGSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIKSDNVLLGMEGSVK 16 1 Q13177;H7C1X3 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 60621600.0 22504700.0 26796900.0 11320000.0 True False 34141275.21395102 22014783.82986469 9082597.038267741 1.0 0.6448143395905982 0.2660298123415248 25.025013609820437 -7.415725309704027 0.32539350348600243 1.0673178594638024 5.3987713456103775e-12 0.9996781234185218 0.005376777300421165 0.11665392807321061 0.030095755321415674 0.01735941788126859 0.05906160402801512 3.839500162413768e-08 7.415725309704027 -1.0673178594584036 down DIK(ub)SDNVLLGMEGSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIKSDNVLLGMEGSVK 16 1 Q13177;H7C1X3 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 28098800.0 11600600.0 10518400.0 5979800.0 True False 9646412.893716838 10461735.291461064 7230148.532528694 1.0 1.0845207857809283 0.7495168009279417 23.201561132168035 -6.839841540168337 1.2830944343729112 1.0449639659449257 0.7385299795271081 0.9241917518637208 0.03916586862903862 0.16897955083771943 0.5404623216866044 0.02393573224896005 0.055142072175929896 1.4459672606006993e-07 6.839841540168337 -0.3064339864178176 DIK(ub)SDNVLLGMEGSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIKSDNVLLGMEGSVK 16 1 Q13177;H7C1X3 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 52822700.0 22504700.0 18577000.0 11741000.0 True False 29132777.78395751 17543173.619504552 9604258.472833356 1.0 0.6021799139649847 0.3296719092170508 24.796139931912887 -8.174523525343119 0.20380643771345355 1.265010206143207 2.9090402476450084e-08 0.9997805823128235 0.004077200888554092 0.08691728942403548 0.04143703634944886 0.09935736210715958 0.11181342530481161 6.690775757311735e-09 8.174523525343119 -1.2650101770528044 down DIKPENLLLGLK(ub)GELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIKPENLLLGLKGELK 16 2 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;J3KT86;Q96GD4-2 Q96GD4-5 AURKB Aurora kinase B 1 15631400.0 3618700.0 4261400.0 7751300.0 True False 3503826.3492762344 5962999.242907429 5721001.995984474 1.0 1.7018535305378852 1.632786966501987 21.740499845620004 -10.244723753334853 4.592580311800725 0.9997731872404929 1.6673202485238552 0.9920300935245112 0.028196306709244612 19908304.13295441 18.841914169949682 47750.12580627726 0.009652345762364846 5.692148827459676e-11 10.244723753334853 0.6675470612833623 DIKPENLLLGLK(ub)GELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIKPENLLLGLKGELK 16 2 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;J3KT86;Q96GD4-2 Q96GD4-5 AURKB Aurora kinase B 1 17365600.0 3618700.0 6491400.0 7255500.0 True False 3009109.3855915326 6456429.53975798 8772591.504358348 1.0 2.145628062134661 2.9153448347089004 21.52090512105428 -8.203947940502344 0.1751386118379005 8.150524194637661e-10 4.099648363071306 0.9998681936176593 0.009034619012476503 0.08792508018207207 0.03654540511489208 0.3552250297101026 0.3820653710670809 6.252476376079291e-09 8.203947940502344 4.099648362256254 DILEHHLQNNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DILEHHLQNNK 11 0 G3V5X4;A0A0A0MRE3;Q8WXH0;Q8WXH0-2 G3V5X4 SYNE2 Nesprin-2 0 4718200.0 1174300.0 1710000.0 1833900.0 False True 1539518.6719373777 1454874.6655277943 1644145.620010973 1.0 0.9450191751795614 1.0679608178716855 20.554047934432205 -6.7851073495093575 1.5156248423796368 0.9690749779958013 1.0691014272231116 0.78515397118824 0.023307322188614508 0.24271907068576154 1.101451838722859 0.012107507786297732 0.028453346988150906 1.640184300070176e-07 6.7851073495093575 0.1000264492273103 DILEHHLQNNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DILEHHLQNNK 11 0 G3V5X4;A0A0A0MRE3;Q8WXH0;Q8WXH0-2 G3V5X4 SYNE2 Nesprin-2 0 8036200.0 1920900.0 3978200.0 2137100.0 False True 2914145.736600731 3268259.128181528 1714701.2482757962 1.0 1.121515333681925 0.5884061413743662 21.47464159779512 -6.846789951399813 1.2506024534749904 1.0647054670664364 0.5683922427374425 0.9354845663419384 0.05794422228372663 0.16102523561844748 0.4862723424066379 0.0362850149446084 0.08380545957020281 1.4230168696169556e-07 6.846789951399813 -0.49631322432899394 DILEHHLQNNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DILEHHLQNNK 11 0 G3V5X4;A0A0A0MRE3;Q8WXH0;Q8WXH0-2 G3V5X4 SYNE2 Nesprin-2 0 4966300.0 1920900.0 1496100.0 1549300.0 False True 2486642.916599819 1412840.7198224051 1267343.2971604394 1.0 0.5681719359023581 0.5096603491800813 21.24576791988757 -13.999999999999998 0.2816659400659222 4.551867360625888 0.49233312696693216 0.9996088698963715 0.00432454906746203 15.48910856934369 0.16814747384488285 31.722520088114056 0.022964018069528587 1.0000000000000041e-14 13.999999999999998 -4.0595342336589555 DILHK(ub)TVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DILHKTVK 8 1 Q96G04-2;Q96G04 Q96G04-2 EEF2KMT Protein-lysine N-methyltransferase EEF2KMT 1 10212170.0 942970.0 1679500.0 7589700.0 True False 1430554.4303411918 1379780.1030066074 6089592.468316316 1.0 0.9645072384121207 4.256805850347077 20.448142960301865 -6.904462838433479 0.9326134775989051 0.8793692799999773 4.635508399396166 0.9886590509920229 0.16439533757291672 0.10819469920283425 0.15946869222802018 0.13101158389501366 0.34917688183705775 1.2460548547186732e-07 6.904462838433479 3.756139119396188 up DILHK(ub)TVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DILHKTVK 8 1 Q96G04-2;Q96G04 Q96G04-2 EEF2KMT Protein-lysine N-methyltransferase EEF2KMT 1 5695670.0 942970.0 1387800.0 3364900.0 True False 1220693.2537175983 1310567.7100257557 2752522.7267896193 1.0 1.0736257499862856 2.2548848520354015 20.219269282394315 -6.919625472338559 0.8275062567108669 0.9735829770136555 2.4437381881151867 0.9940761440179157 0.04425508101563207 0.09839250123091309 0.1067618891347076 0.0380548822882868 0.1135864113601318 1.2033016927888194e-07 6.919625472338559 1.4701552111015312 up DILIQYDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DILIQYDR 8 0 P62249;M0R210 P62249 RPS16 40S ribosomal protein S16 0 67796000.0 22246000.0 18550000.0 27000000.0 False True 29164721.43057045 15782412.307333663 24206299.00228822 1.0 0.5411473702879447 0.8299856064085421 24.797720958399083 -10.498120803655622 6.027559008036137 1.000296771611618 0.685566488348244 0.6124194602668125 0.1179177161168316 0.00047070314852290404 3.919249528312379e-05 0.11427915063239429 0.038057779228608535 3.1759905120365577e-11 10.498120803655622 -0.31473028326337404 DILIQYDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DILIQYDR 8 0 P62249;M0R210 P62249 RPS16 40S ribosomal protein S16 0 39562200.0 12289000.0 6551200.0 20722000.0 False True 11898892.4216585 9167128.324056674 15294286.553325268 1.0 0.7704186237847283 1.285353796920328 23.5043239543711 -6.785544940868316 1.514508893555618 0.8709384799184203 1.290146285167806 0.7864278748451782 0.09734119566764642 0.24206196437325617 1.0969572915432817 0.05060827427039431 0.11886087870727997 1.6385324968845248e-07 6.785544940868316 0.4192078052493857 DILIQYDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DILIQYDR 8 0 P62249;M0R210 P62249 RPS16 40S ribosomal protein S16 0 55122000.0 10134000.0 32508000.0 12480000.0 False True 15374018.894638885 26706693.413836703 10013322.529821694 1.0 1.7371315592144658 0.6513145715798142 23.873991010858425 -6.723891806340833 1.7453592697696818 1.4465876978396612 0.6526296295725826 0.530803532186352 0.3100486591878773 0.3478058621486665 2.072648850388046 0.1409399206966932 0.3521963392640532 1.8884617537350574e-07 6.723891806340833 -0.7939580682670786 DILIQYDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DILIQYDR 8 0 P62249;M0R210 P62249 RPS16 40S ribosomal protein S16 0 50226000.0 22246000.0 13439000.0 14541000.0 False True 30470947.375545323 12845220.543169936 11106715.281295419 1.0 0.42155632330220755 0.3645018037807775 24.860931019921974 -13.999999999999998 0.3274755115345846 7.201860849237215 0.3540963834162771 0.9997095778563145 0.004892270372470062 18.61231449149371 0.18286016297804897 79.3983610338558 0.01845747833708289 1.0000000000000041e-14 13.999999999999998 -6.847764465820938 DILIQYDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DILIQYDR 8 0 P62249;M0R210 P62249 RPS16 40S ribosomal protein S16 0 26389800.0 12289000.0 8587700.0 5513100.0 False True 10218847.995007686 8541436.355575021 6665863.7203057 1.0 0.8358511996408845 0.6523106835097497 23.284729229805375 -6.9696802753080425 0.2657111539825942 1.0480654892831833 0.43460999662546634 0.9999797790811805 0.0006385919718648441 0.07640659958646548 0.00940070742104146 0.0036946894375679525 0.017173214403180856 1.0723084410237922e-07 6.9696802753080425 -0.6134554926577169 DILIQYDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DILIQYDR 8 0 P62249;M0R210 P62249 RPS16 40S ribosomal protein S16 0 39610000.0 10134000.0 18935000.0 10541000.0 False True 13118662.77100452 17881250.604797296 8622646.159793569 1.0 1.363039123493537 0.6572808761310446 23.645117332950875 -6.7669059536446925 1.58641924644775 1.2090565279678465 0.6537802941437213 0.7185122416812368 0.15288683383424884 0.2714780379806587 1.3479192796006294 0.07598650842277946 0.18138874626071005 1.710385658552395e-07 6.7669059536446925 -0.5552762338241252 DILK(ub)PSPGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DILKPSPGK 9 1 A0A087WY96;P31641;A0A087WYN0;C9JPV1;P31641-2 A0A087WY96 SLC6A6 Transporter;Sodium- and chloride-dependent taurine transporter 1 2410570.0 701010.0 920910.0 788650.0 True False 919030.8985904972 783513.8176790647 707048.0632649844 1.0 0.8525434986796713 0.7693409050222061 19.80975384138519 -13.999999999471937 0.06657126685090613 1.878985963003109 0.4448346559062918 0.9999355664799292 0.000765568313780647 12.395995945623593 0.06846372764044747 1.7300552917448078 0.30059196317116166 1.0000000012159098e-14 13.999999999471937 -1.4341513070968173 DILK(ub)PSPGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DILKPSPGK 9 1 A0A087WY96;P31641;A0A087WYN0;C9JPV1;P31641-2 A0A087WY96 SLC6A6 Transporter;Sodium- and chloride-dependent taurine transporter 1 4701000.0 1352300.0 1221900.0 2126800.0 True False 2051537.9663726252 1003842.3982517243 1706437.047790447 1.0 0.48931212324899975 0.8317842885489662 20.968274422745786 -10.18946441426551 7.52255265175682 1.0000002713197491 0.6605482058989863 0.5670843597411805 0.13981367601516884 6.361844507055717e-07 6.864846526878359e-08 0.13537411862215262 0.04512466989823238 6.464509614922807e-11 10.18946441426551 -0.3394520654207628 DILK(ub)PSPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DILKPSPGK 9 1 A0A087WY96;P31641;A0A087WYN0;C9JPV1;P31641-2 A0A087WY96 SLC6A6 Transporter;Sodium- and chloride-dependent taurine transporter 1 2154610.0 701010.0 450700.0 1002900.0 True False 960192.3410829379 430786.58373440744 766035.6753738511 1.0 0.44864613609451576 0.7977939862651786 19.872963902908083 -10.100242005515396 5.25561849642195 1.000007035630342 0.6232200611794556 0.6082623017543978 0.14253901295271523 1.1750903062267895e-05 2.0117753500464514e-06 0.13801538169839697 0.04600426861235602 7.93885727917658e-11 10.100242005515396 -0.3767869744508865 DILPCLDGYLK(ub)TSALSDETK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DILPCLDGYLKTSALSDETK 20 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 38384400.0 3379900.0 4873500.0 30131000.0 True False 4375347.177789441 4602285.440849194 24647467.170167923 1.0 1.05186748704463 5.633259754856888 22.060966066681225 -6.909373058258815 0.8999909954561864 0.8553230480830044 6.217461493045228 0.9906828843074771 0.2096544426780923 0.10483412570083504 0.1410258419157781 0.17111659289447165 0.4703339579410492 1.232046052978299e-07 6.909373058258815 5.362138444962223 up DIMAEIYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIMAEIYK 8 0 P07858 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 10598300.0 2490400.0 3661400.0 4446500.0 False True 3264938.5170679055 3115133.3920254153 3986418.8338397993 1.0 0.9541170149883792 1.220978224551629 21.638624393574776 -6.862600187024204 1.1726121176555226 0.9749149006616628 1.2345524067729607 0.9567185543274234 0.0242370113858753 0.14414237265362723 0.37516179392296267 0.016103876679379184 0.03770603740305531 1.372144385673847e-07 6.862600187024204 0.259637506111298 DIMAEIYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIMAEIYK 8 0 P07858 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 7898400.0 2278500.0 1237600.0 4382300.0 False True 2206170.264687844 1731780.1339987384 3234444.1638180353 1.0 0.7849712063106661 1.4660900002093373 21.07311270682723 -6.8218203665923935 1.3639374243324358 0.8843091787435267 1.481553571941346 0.8885297935717429 0.09491717852307047 0.19112481464324022 0.6981365656241754 0.05467853700180294 0.1259708264390295 1.5072303597140916e-07 6.8218203665923935 0.5972443931978193 DIMAEIYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIMAEIYK 8 0 P07858 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 9618700.0 2490400.0 3049900.0 4078400.0 False True 3411168.180529446 2915145.333329413 3115165.9172845925 1.0 0.8545885687984328 0.9132255439839055 21.701834455097668 -10.95591967774656 10.365034429804275 1.0405426211531672 0.8839070564161154 0.8393949762702508 0.02393844487744131 0.01568582326186273 6.670846092960317e-05 0.016210958573162022 0.0077260998620361865 1.1068284716722554e-11 10.95591967774656 -0.15663556473705176 DIMAEIYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIMAEIYK 8 0 P07858 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 5247700.0 2278500.0 1404600.0 1564600.0 False True 1894673.704664744 1397033.1410087307 1891750.6261069628 1.0 0.7373476169375196 0.9984572126849154 20.853517982261508 -10.89780169765038 9.613212312577133 1.0137543762434325 0.8679024148112195 0.25443128174129537 0.10659754608758468 0.03176784425979428 0.0003377243190059002 0.10434268077242322 0.03440421006198274 1.2653139681115547e-11 10.89780169765038 -0.1458519614322129 DINAVLIDMER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DINAVLIDMER 11 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 5725400.0 1357900.0 1881900.0 2485600.0 False True 1780220.049922304 1601127.8555887435 2228413.955558798 1.0 0.8993988443499573 1.251763205147619 20.76362415057776 -6.830421033348073 1.3262586411729305 0.9462631267123393 1.261311232020587 0.906669288062855 0.045274843718251835 0.1802951113485806 0.6201164485847861 0.026803673375309336 0.06167467698825833 1.4776751390453646e-07 6.830421033348073 0.3150481053082478 DINAYNCEEPTEK(ub)LPFPIIDDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DINAYNCEEPTEKLPFPIIDDR 22 1 P30041 P30041 PRDX6 Peroxiredoxin-6 1 35719700.0 7803600.0 9115100.0 18801000.0 True False 11838631.719578044 7488439.188398651 15084974.109228976 1.0 0.6325426253453517 1.2742160130112266 23.496999011609933 -6.751428084879816 1.6449395778066163 0.7842997580298597 1.2756023131983074 0.6549543307451009 0.15441862732484674 0.297553406700618 1.5845821138828156 0.07414971918464316 0.17971954295086298 1.7724415206392575e-07 6.751428084879816 0.4913025551684477 DINAYNCEEPTEK(ub)LPFPIIDDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DINAYNCEEPTEKLPFPIIDDR 22 1 P30041 P30041 PRDX6 Peroxiredoxin-6 1 6528600.0 1499600.0 2276500.0 2752500.0 True False 2054042.6451662206 2175916.7026212057 2102416.189516928 1.0 1.0593337522674084 1.023550408977411 20.97003470391658 -10.411886879122212 5.2281607596060695 0.9999651107519082 1.041442080622411 0.6413688961204835 0.014608488725227168 5.945843456737941e-06 6.688348264933013e-07 0.014156514458813442 0.004714869462171353 3.8735852723131525e-11 10.411886879122212 0.041476969870502756 DINAYNCEEPTEK(ub)LPFPIIDDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DINAYNCEEPTEKLPFPIIDDR 22 1 P30041 P30041 PRDX6 Peroxiredoxin-6 1 33993300.0 7803600.0 7782700.0 18407000.0 True False 10101914.03195291 7349585.903456874 15057114.871769305 1.0 0.727543897147583 1.490520986829112 23.268125333702383 -6.810147069817869 1.4139025751495506 0.8515399558821756 1.5039156157905293 0.8602149123709384 0.11803202817087596 0.20659970048404783 0.8139937032283764 0.06563977851510368 0.1518290725397356 1.5482922152569085e-07 6.810147069817869 0.6523756599083538 DINEAFK(ub)ELGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DINEAFKELGR 11 1 P15884-2;P15884-3;A0A1B0GVR6;P15884-13;P15884-4;P15884-11;E9PH57;A0A1B0GW91;A0A1B0GWD5;H3BTP3;A0A1B0GVB8;H0YNP8;K7EKB9;K7EPS2;K7ERZ7;P15923;P15923-3;A0A494C1R3;F5GY10;Q99081-4;Q99081-2;Q99081;Q99081-3;B4DZP2;B4DGI9;P15884-6;H3BPJ7;P15884-16;P15884-8;P15884-9;P15884-15;P15884-7;P15884-5;P15884-10;P15884-14;P15884-12;P15884 P15884-2;F5GY10;P15884-6 TCF4;TCF12;TCF3 Transcription factor 4;Transcription factor E2-alpha;Transcription factor 12 1 18817500.0 5818900.0 6158200.0 6840400.0 True False 7628634.250307759 5239420.564475593 6132621.025750075 1.0 0.686809773881114 0.8038950124660477 22.862993364696724 -10.284025359148197 6.296241638438972 1.0000079066038812 0.7453523934378418 0.8631424290201348 0.04779984849085316 5.305346598596751e-06 6.032438844185327e-07 0.046283440951100326 0.015427334763025932 5.1996563402351405e-11 10.284025359148197 -0.2546555131660394 DINEAFK(ub)ELGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DINEAFKELGR 11 1 P15884-2;P15884-3;A0A1B0GVR6;P15884-13;P15884-4;P15884-11;E9PH57;A0A1B0GW91;A0A1B0GWD5;H3BTP3;A0A1B0GVB8;H0YNP8;K7EKB9;K7EPS2;K7ERZ7;P15923;P15923-3;A0A494C1R3;F5GY10;Q99081-4;Q99081-2;Q99081;Q99081-3;B4DZP2;B4DGI9;P15884-6;H3BPJ7;P15884-16;P15884-8;P15884-9;P15884-15;P15884-7;P15884-5;P15884-10;P15884-14;P15884-12;P15884 P15884-2;F5GY10;P15884-6 TCF4;TCF12;TCF3 Transcription factor 4;Transcription factor E2-alpha;Transcription factor 12 1 42167100.0 10782600.0 12834900.0 18549600.0 True False 10440312.265096849 17959942.50311928 13690903.283928331 1.0 1.7202495526078667 1.3113499803735351 23.31566152713173 -10.391455098058485 5.314978474356712 0.9996993383154481 1.5157997664907128 0.6796535660263585 0.1669325513361118 0.0005950720986081443 6.813323485719158e-05 0.1617237453690809 0.053877249272050336 4.0601763946503216e-11 10.391455098058485 0.5161004281752647 DINEAFK(ub)ELGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DINEAFKELGR 11 1 P15884-2;P15884-3;A0A1B0GVR6;P15884-13;P15884-4;P15884-11;E9PH57;A0A1B0GW91;A0A1B0GWD5;H3BTP3;A0A1B0GVB8;H0YNP8;K7EKB9;K7EPS2;K7ERZ7;P15923;P15923-3;A0A494C1R3;F5GY10;Q99081-4;Q99081-2;Q99081;Q99081-3;B4DZP2;B4DGI9;P15884-6;H3BPJ7;P15884-16;P15884-8;P15884-9;P15884-15;P15884-7;P15884-5;P15884-10;P15884-14;P15884-12;P15884 P15884-2;F5GY10;P15884-6 TCF4;TCF12;TCF3 Transcription factor 4;Transcription factor E2-alpha;Transcription factor 12 1 67012400.0 12174900.0 13165000.0 41672500.0 True False 18470213.404414747 10815602.89138552 33435912.109294377 1.0 0.5855700015247456 1.8102612772899815 24.138697199493027 -6.815419311474233 1.3916633464620936 0.7755411321806426 1.8344412973244777 0.8735018003515382 0.18089470845979563 0.1995019045370567 0.7604282291649439 0.10217819098280438 0.2358300322966163 1.5296099096053656e-07 6.815419311474233 1.058900165143835 DINEAFK(ub)ELGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DINEAFKELGR 11 1 P15884-2;P15884-3;A0A1B0GVR6;P15884-13;P15884-4;P15884-11;E9PH57;A0A1B0GW91;A0A1B0GWD5;H3BTP3;A0A1B0GVB8;H0YNP8;K7EKB9;K7EPS2;K7ERZ7;P15923;P15923-3;A0A494C1R3;F5GY10;Q99081-4;Q99081-2;Q99081;Q99081-3;B4DZP2;B4DGI9;P15884-6;H3BPJ7;P15884-16;P15884-8;P15884-9;P15884-15;P15884-7;P15884-5;P15884-10;P15884-14;P15884-12;P15884 P15884-2;F5GY10;P15884-6 TCF4;TCF12;TCF3 Transcription factor 4;Transcription factor E2-alpha;Transcription factor 12 1 25122300.0 5818900.0 8874800.0 10428600.0 True False 7970304.579859781 8482681.990960976 7965579.46375886 1.0 1.064285800619957 0.9994071599079336 22.926203426219615 -6.648265550395034 2.0145507077288936 1.0417718161608918 0.9996787053556134 0.18711477888630612 0.027449538833834695 0.5127943114612611 3.9869917933579186 0.011057616766378904 0.030404866621737567 2.2476798363878043e-07 6.648265550395034 -0.04209311080527833 DINEAFK(ub)ELGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DINEAFKELGR 11 1 P15884-2;P15884-3;A0A1B0GVR6;P15884-13;P15884-4;P15884-11;E9PH57;A0A1B0GW91;A0A1B0GWD5;H3BTP3;A0A1B0GVB8;H0YNP8;K7EKB9;K7EPS2;K7ERZ7;P15923;P15923-3;A0A494C1R3;F5GY10;Q99081-4;Q99081-2;Q99081;Q99081-3;B4DZP2;B4DGI9;P15884-6;H3BPJ7;P15884-16;P15884-8;P15884-9;P15884-15;P15884-7;P15884-5;P15884-10;P15884-14;P15884-12;P15884 P15884-2;F5GY10;P15884-6 TCF4;TCF12;TCF3 Transcription factor 4;Transcription factor E2-alpha;Transcription factor 12 1 34726700.0 10782600.0 13570000.0 10374100.0 True False 8966209.650172519 13496895.716565909 12543276.345581131 1.0 1.5053067286137143 1.3989497050562258 23.096066802566007 -10.123623284454554 5.110602898753047 0.999984987676234 1.4521282168357141 0.9601516599708211 0.04342007304875886 7.4271927012541475e-06 1.2737040987196566e-06 0.04204270003825589 0.014013768317040973 7.522751492963247e-11 10.123623284454554 0.45214322915948013 DINEAFK(ub)ELGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DINEAFKELGR 11 1 P15884-2;P15884-3;A0A1B0GVR6;P15884-13;P15884-4;P15884-11;E9PH57;A0A1B0GW91;A0A1B0GWD5;H3BTP3;A0A1B0GVB8;H0YNP8;K7EKB9;K7EPS2;K7ERZ7;P15923;P15923-3;A0A494C1R3;F5GY10;Q99081-4;Q99081-2;Q99081;Q99081-3;B4DZP2;B4DGI9;P15884-6;H3BPJ7;P15884-16;P15884-8;P15884-9;P15884-15;P15884-7;P15884-5;P15884-10;P15884-14;P15884-12;P15884 P15884-2;F5GY10;P15884-6 TCF4;TCF12;TCF3 Transcription factor 4;Transcription factor E2-alpha;Transcription factor 12 1 75187500.0 12174900.0 19729500.0 43283100.0 True False 15760648.053157985 18631535.981375657 35406019.922109954 1.0 1.1821554493530124 2.246482492514995 23.909823521585476 -6.936399361709818 0.6922555954682147 0.9869894766244927 2.505443270728968 0.9976531592932026 0.026630562799729644 0.08944838238665906 0.06238308774981617 0.0252635314007615 0.09314995915721971 1.1577122756239625e-07 6.936399361709818 1.5184537941044756 up DINITKPASVFVQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DINITKPASVFVQLR 15 1 P19838;P19838-2;P19838-3;A0A494C1E9;D6RF93 P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit;Nuclear factor NF-kappa-B p50 subunit 0 5716300.0 1784900.0 2089600.0 1841800.0 False True 2340021.1849961886 1777839.8251970059 1651228.2037931243 1.0 0.7597537306910755 0.7056466900302075 21.15809016039379 -13.999999999999996 0.2094612064076658 2.386361911587862 0.6736107219306402 0.9994897145786088 0.002889819166669391 12.734161747436731 0.14506606141712441 7.263589182095023 0.03217181326176697 1.0000000000000082e-14 13.999999999999996 -1.7127511896572218 DINITKPASVFVQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DINITKPASVFVQLR 15 1 P19838;P19838-2;P19838-3;A0A494C1E9;D6RF93 P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit;Nuclear factor NF-kappa-B p50 subunit 0 15092400.0 4822800.0 5879700.0 4389900.0 False True 7316540.193908067 4830421.596694226 3522234.3408384765 1.0 0.6602057077081536 0.4814070923537297 22.80273016522842 -13.083149844243021 0.0882464027309734 2.5264335973528897 7.476995843984754e-24 0.9998756059093812 0.002398920652186762 8.838312482615775 0.07665108351833468 2.788693613740178 0.39927382772628367 8.257529915923705e-14 13.083149844243021 -2.5264335973528897 DINITKPASVFVQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DINITKPASVFVQLR 15 1 P19838;P19838-2;P19838-3;A0A494C1E9;D6RF93 P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit;Nuclear factor NF-kappa-B p50 subunit 0 9189600.0 1784900.0 2999800.0 4404900.0 False True 2444825.765108822 2867258.916987958 3364553.3417631714 1.0 1.172786608316987 1.3761935062122561 21.22130022191668 -6.968970962555092 0.28168006812876417 0.9560853074855472 1.5991073397349083 0.9999732059551735 0.0007958338312181243 0.07663803362932044 0.01021989411504058 0.003721175710545556 0.01863093886152673 1.0740612229496651e-07 6.968970962555092 0.643022032249361 DINITKPASVFVQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DINITKPASVFVQLR 15 1 P19838;P19838-2;P19838-3;A0A494C1E9;D6RF93 P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit;Nuclear factor NF-kappa-B p50 subunit 0 7783200.0 3790600.0 1579000.0 2413600.0 False True 3152051.8520527463 1570493.613593038 2918272.6007744884 1.0 0.4982448536086954 0.9258326759041063 21.587859837013152 -10.144222645497289 7.648925232332759 1.0000000819515227 0.7120387647564015 0.37683930212311534 0.17456199747526754 2.440565378640568e-07 2.7000333941926323e-08 0.1690189751282445 0.05633964242520103 7.174264010136342e-11 10.144222645497289 -0.2879613171951212 DIPNENELQFQIKECHLNADTVSSK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIPNENELQFQIKECHLNADTVSSK 25 1 P63010;P63010-2;A0A087X253;P63010-3 P63010 AP2B1 AP-2 complex subunit beta 1 22771100.0 6546000.0 7500900.0 8724200.0 True False 8473926.040950814 7083468.32117897 7136485.117851348 1.0 0.8359133991667659 0.8421698612147198 23.014599106473096 -10.045017672443674 4.744093999961163 1.0000047198375066 0.8390416301873148 0.9988681154382957 0.0025541899485273566 1.2817608826954698e-07 2.580272130592757e-08 0.0024731566657615694 0.0008243612592833922 9.015344513443511e-11 10.045017672443674 -0.1609630896501918 DIQDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIQDLK 6 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 23428500.0 6180200.0 2537300.0 14711000.0 False True 5984012.9338704515 3550457.1218447047 10857747.779459907 1.0 0.593323771368969 1.8144592766508494 22.512681862800157 -6.816919420596124 1.3850802085486011 0.7800916028982451 1.8394117898104252 0.8771597000332693 0.17794424296550493 0.19751926097978234 0.7453824886972676 0.10097562101803395 0.23295317525006598 1.5243355542036668e-07 6.816919420596124 1.05932018691218 DIQDSLTVSNEVQTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIQDSLTVSNEVQTAK 16 0 P47755 P47755 CAPZA2 F-actin-capping protein subunit alpha-2 0 5792000.0 0.0 2395300.0 3396700.0 False True 0.0 2037930.576806273 3045242.067447125 0.0 DIQDSLTVSNEVQTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIQDSLTVSNEVQTAK 16 0 P47755 P47755 CAPZA2 F-actin-capping protein subunit alpha-2 0 4315000.0 0.0 2097100.0 2217900.0 False True 0.0 2004443.1878176723 1694077.6990843206 0.0 DIQEESTFSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIQEESTFSSR 11 0 P42704;B8ZZ38;A0A0C4DG06;C9JCA9 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 5915900.0 1314500.0 2090400.0 2511000.0 False True 1723322.229636108 1778520.4683153806 2251185.8072128007 1.0 1.0320301321076373 1.3063057903501627 20.716761053611005 -6.928851533437645 0.7561484472271741 0.9956467861517864 1.3610031303033108 0.9963079585479168 0.008352833603000466 0.0932380747321244 0.08063039754075224 0.0075585542815540495 0.024975667888255844 1.1780086150594024e-07 6.928851533437645 0.3653563441515244 DIQENDEEAVQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIQENDEEAVQVK 13 0 O00231;O00231-2;J3QRY4 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 4735300.0 1226700.0 1508700.0 1999900.0 False True 1608215.5793796997 1283607.840866538 1792969.5323954124 1.0 0.7981565763475782 1.1148813351795621 20.61702938035312 -6.734563990028584 1.706774954054942 0.8791509908606587 1.1148486357911487 0.5801954687549392 0.08482408861656332 0.3277550592082716 1.8724989884701673 0.03935332083426895 0.09714516633903708 1.8426209726133885e-07 6.734563990028584 0.23569764493048995 DIQENDEEAVQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIQENDEEAVQVK 13 0 O00231;O00231-2;J3QRY4 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 4140500.0 1226700.0 1478100.0 1435700.0 False True 1680244.1403210228 1412792.65457694 1096617.2291696463 1.0 0.8408258185069556 0.6526535060316471 20.68023944187601 -6.968911940399501 0.2829714350944859 1.0399998369908479 0.4477220833310191 0.9999726056381031 0.0007430339846318391 0.07665737168529545 0.010288164443134183 0.0034173417037957274 0.01720801828405382 1.0742072015866193e-07 6.968911940399501 -0.5922777536598287 DIQHWESLK(ub)PEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIQHWESLKPEER 13 1 P31350;P31350-2;A0A286YFD6;C9JXC1 P31350 RRM2 Ribonucleoside-diphosphate reductase subunit M2 1 46254600.0 1731200.0 7794400.0 36729000.0 True False 2241072.527053784 7360634.788171739 30044698.871364985 1.0 3.28442506849538 13.406392925115687 21.095757908367787 -6.942532301521502 0.635567889493873 0.8894578254711754 16.352109971681028 0.9984771365749834 0.21038800143580705 0.08663012059201285 0.04948957347867656 0.20896411252363628 0.8619284034844195 1.1414784017202295e-07 6.942532301521502 15.462652146209852 DIQNTQCLLNVEHLSAGCPHVTLQFADSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIQNTQCLLNVEHLSAGCPHVTLQFADSK 29 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 427862000.0 98783000.0 203199000.0 125880000.0 False True 149861033.0046492 166936550.8489666 100999762.82483612 1.0 1.1139423471329446 0.6739561365608815 27.159050060335453 -6.837958123471124 1.2919235822058586 1.0606388032080596 0.6600668427443365 0.9208726975118349 0.05244783672504184 0.1711978547677078 0.5559474037175192 0.031844193040016615 0.07332442912673451 1.4522516431428977e-07 6.837958123471124 -0.4005719604637231 DIQNTQCLLNVEHLSAGCPHVTLQFADSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIQNTQCLLNVEHLSAGCPHVTLQFADSK 29 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 231363800.0 98783000.0 75121000.0 57459800.0 False True 127876540.80403998 70940450.31333378 47002705.98733584 1.0 0.5547573453839671 0.3675631643755794 26.930176382427902 -13.999999999999812 0.11865873495373633 3.124372737452551 0.06331820218983544 0.9996995479972471 0.004597869616597023 11.969117700495733 0.10583817715480162 6.006953344701008 0.2699675047410127 1.0000000000004336e-14 13.999999999999812 -3.061054535262716 DIQNTQCLLNVEHLSAGCPHVTLQFADSK(ub)GDVGLGLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIQNTQCLLNVEHLSAGCPHVTLQFADSKGDVGLGLVK 38 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 625157000.0 59553000.0 91821000.0 473783000.0 True False 90346254.90748271 75434825.14925247 380139582.38353395 1.0 0.8349524308063462 4.207585392142799 26.428961462994984 -6.895396746701586 0.9899252736436658 0.8415250814714383 4.530272178149692 0.9841331737374136 0.19555032329843564 0.11487294468065568 0.19715045439655737 0.14934681205147918 0.3803292071761687 1.2723402123857512e-07 6.895396746701586 3.688747096678254 up DIQNTQCLLNVEHLSAGCPHVTLQFADSK(ub)GDVGLGLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIQNTQCLLNVEHLSAGCPHVTLQFADSKGDVGLGLVK 38 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 573165700.0 59553000.0 65768700.0 447844000.0 True False 77092532.46513051 62108614.02966632 366340987.2674887 1.0 0.8056372263780345 4.7519646268357745 26.200087785087433 -6.8953190132326565 0.9903987032637146 0.8141966825508836 5.128960256688415 0.984089664752739 0.22909343865637405 0.11493297822493861 0.19749294072484852 0.17490216236427797 0.44526104826631663 1.272567966304522e-07 6.8953190132326565 4.314763574137531 up DIQNTQCLLNVEHLSAGCPHVTLQFADSKGDVGLGLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIQNTQCLLNVEHLSAGCPHVTLQFADSKGDVGLGLVK 38 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 55629000.0 11547000.0 18025000.0 26057000.0 False True 17517643.19877591 14808297.920032205 20906822.52881121 1.0 0.8453361991678751 1.1934723348099776 24.062305353867877 -6.785940134184061 1.5125771624223845 0.9131003082207699 1.1967689667244799 0.7878876252380949 0.0655924871032006 0.24145503886828437 1.0913653609716345 0.03414210175819672 0.0801756617636149 1.6370421658113275e-07 6.785940134184061 0.2836686585037099 DIQNTQCLLNVEHLSAGCPHVTLQFADSKGDVGLGLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIQNTQCLLNVEHLSAGCPHVTLQFADSKGDVGLGLVK 38 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 38196000.0 11547000.0 6376000.0 20273000.0 False True 14947819.12539857 6021169.995045549 16583522.018546171 1.0 0.402812607279592 1.1094275278169707 23.833431675960327 -6.682666348948015 1.8921972690866717 0.6230684291245971 1.1068117265652808 0.336482866912835 0.252954619784601 0.43261680745065717 2.9969257820065 0.10717366423852237 0.2817238677202915 2.0765082028743798e-07 6.682666348948015 0.4837432974406837 DIQSCTVEVHFQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIQSCTVEVHFQK 13 0 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578;C9JWF0;C9IYK2;C9JJ64 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 18827300.0 2098800.0 11568000.0 5160500.0 False True 3184033.042832847 9503600.018803475 4140524.913072496 1.0 2.984768025632072 1.3004026206300467 21.60242387709133 -6.606072801839542 2.1682772884061867 2.3295028103807995 1.3062189598088114 0.03837153217318501 0.8565531345834053 0.6235402820143929 5.549273848398001 0.32688148134428896 0.9515668632135459 2.4770067961590794e-07 6.606072801839542 -1.0232838505719881 DIQTNVYIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIQTNVYIK 9 0 R4GMR5;P48556;K7EJR3;K7EJC1;K7ERW6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 21144100.0 7852600.0 7929000.0 5362500.0 False True 10294834.644686576 6746024.106999921 4807639.940732239 1.0 0.6552824149032558 0.4669953531709791 23.295417321844987 -11.331920999463959 0.10027997060827032 2.0791975488726377 7.484950567839209e-22 0.999880798991882 0.00240957772185242 4.014341454208238 0.06487859264703572 1.288333149898351 0.3175207987038669 4.656707938773951e-12 11.331920999463959 -2.0791975488726377 DIQTNVYIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIQTNVYIK 9 0 R4GMR5;P48556;K7EJR3;K7EJC1;K7ERW6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 15857500.0 3382100.0 1259400.0 11216000.0 False True 3274737.086767941 1762284.987684239 8278193.127212448 1.0 0.5381454880164309 2.527895494469376 21.64294765342711 -6.845599190017645 1.2562428266814545 0.7541891367407798 2.6008903963162617 0.9336388930585409 0.21903924411410908 0.16236509469161317 0.49532135241700886 0.13658254567902336 0.31527824684669103 1.4269238928659918e-07 6.845599190017645 1.846701259575482 up DIQTNVYIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIQTNVYIK 9 0 R4GMR5;P48556;K7EJR3;K7EJC1;K7ERW6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 30087000.0 6695700.0 15788000.0 7603300.0 False True 10157866.42123876 12970508.047792964 6100504.422355227 1.0 1.276892952704452 0.6005694669896305 23.276094071563634 -6.795533543668835 1.4740124678021254 1.1536496165368522 0.5922239881884469 0.8188008074817097 0.11817351551033912 0.22719588699199245 0.9749356371520538 0.06308405131933208 0.1471316182500517 1.6012769654958637e-07 6.795533543668835 -0.5614256283484053 DIQTNVYIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIQTNVYIK 9 0 R4GMR5;P48556;K7EJR3;K7EJC1;K7ERW6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 14820100.0 7852600.0 3437200.0 3530300.0 False True 10755918.428535793 3285333.138699583 2696515.8488107603 1.0 0.30544422222313344 0.2507006599879763 23.358627383367878 -13.987407434529848 0.36011888815762766 9.999999984619667 0.24407879175519825 0.9997731392361017 0.005136901551336964 21.493244869533015 0.19380035223879005 148.61701454282465 0.015798912162929828 1.0294199142419794e-14 13.987407434529848 -9.755921192864468 DIQTNVYIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIQTNVYIK 9 0 R4GMR5;P48556;K7EJR3;K7EJC1;K7ERW6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 9506000.0 3382100.0 3088600.0 3035300.0 False True 2812366.0024343324 3071961.0987609006 3669967.1963584665 1.0 1.0923048764285543 1.304939397355042 21.423352928861387 -6.957190187408218 0.47337658124515586 0.994564122519547 1.411446832557276 0.9996513645651455 0.0023840225541879737 0.08072058448682289 0.024959216187548074 0.00295899673453912 0.017546019805716365 1.103595224674324e-07 6.957190187408218 0.41688271003772903 DIQTNVYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIQTNVYIK 9 0 R4GMR5;P48556;K7EJR3;K7EJC1;K7ERW6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 25448200.0 6695700.0 7548500.0 11204000.0 False True 8667715.64197898 7128419.33933521 9164986.96274806 1.0 0.8224103828246582 1.0573705162131444 23.047220393656083 -6.70458486166314 1.8149259528045558 0.8902204629574093 1.056725452789407 0.439191525473021 0.07490200299302227 0.3860514442930971 2.475382709054872 0.03288854179972094 0.08409250576356377 1.9743090593553287e-07 6.70458486166314 0.16650498983199769 DIREEAEK(ub)YAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIREEAEKYAK 11 2 H0YJ03;P25788-2;P25788;G3V4X5 H0YJ03;P25788-2 PSMA3 Proteasome subunit alpha type-3 1 7369640.0 2181800.0 717640.0 4470200.0 True False 2988470.420928023 685932.2918818721 3414430.8266588827 1.0 0.22952621082622815 1.1425345898516823 21.51097583275303 -6.683011645209433 1.8911653300923468 0.5138225432740698 1.139142248588782 0.3378717176248315 0.32633498991445137 0.43192426161823855 2.9892076236651812 0.13833006400922743 0.36343756440118874 2.074857881292066e-07 6.683011645209433 0.6253197053147123 DISDIEGEK(ub)DGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DISDIEGEKDGIR 13 1 E9PB90;P52789 E9PB90 HK2 Hexokinase;Hexokinase-2 1 15881500.0 11654000.0 2389600.0 1837900.0 True False 15086332.734683909 2256616.659372782 1503421.0584465063 1.0 0.14958019944666578 0.09965450748611016 23.846738814775655 -13.442511477905542 0.4088861940470079 9.999913614379341 0.09725634851420849 0.9998393417828044 0.005236872313761682 17.53622006765143 0.211161225059083 138.05142000638324 0.012473899580586085 3.609844730543375e-14 13.442511477905542 -9.902657265865132 DISEASVFDAYVLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DISEASVFDAYVLPK 15 0 P62854 P62854 RPS26 40S ribosomal protein S26 0 9761700.0 2050000.0 4573000.0 3138700.0 False True 2687569.8522282373 3890726.2254143874 2813937.43253637 1.0 1.4476744566057047 1.047019272895684 21.357870821385767 -10.436340054721738 6.418799444007082 0.9999403945101629 1.2473468647506945 0.3369452890113278 0.16356679381510095 0.00013955364579887656 1.225487503213907e-05 0.1584109084297265 0.05279095570320236 3.661507645207455e-11 10.436340054721738 0.24740647024053153 DISEASVFDAYVLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DISEASVFDAYVLPK 15 0 P62854 P62854 RPS26 40S ribosomal protein S26 0 31795300.0 13547000.0 4274300.0 13974000.0 False True 13116957.90025288 5981050.2801800445 10313790.188985966 1.0 0.45597846129129804 0.7862943730868518 23.644929831491464 -10.423305530881144 5.962699662548103 1.0001379834328856 0.6211364171890835 0.6369002503612936 0.1348509063035475 0.0002474469734053843 2.3932168534979606e-05 0.13061591048060603 0.043522942861217946 3.773066582050728e-11 10.423305530881144 -0.3790015662438021 DISEASVFDAYVLPK(ub)LYVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DISEASVFDAYVLPKLYVK 19 1 P62854 P62854 RPS26 40S ribosomal protein S26 1 38093300.0 19695500.0 5105800.0 13292000.0 True False 19070277.133271627 7144572.5663952585 9810426.44854741 1.0 0.37464440167627294 0.5144354421274406 24.184822473561812 -10.022186657500104 7.373421600940094 1.000000034262802 0.4445399219029489 0.9546518814309063 0.0570694532863542 3.212356868738165e-08 4.243498417426997e-09 0.05525726383237338 0.018419086846267623 9.501963164677231e-11 10.022186657500104 -0.555460112359853 DISEASVFDAYVLPK(ub)LYVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DISEASVFDAYVLPKLYVK 19 1 P62854 P62854 RPS26 40S ribosomal protein S26 1 100362000.0 36336000.0 26646000.0 37380000.0 True False 55124368.5174263 21890813.113851763 29991826.615763977 1.0 0.39711680519172726 0.544075649706223 25.71618688804277 -10.236679466969187 8.299450934551524 1.000000244706621 0.4705962274494514 0.945364139764465 0.059995697041587547 2.716503622439076e-07 2.4927274231457652e-08 0.058090610704400976 0.019363527957181183 5.798565042825822e-11 10.236679466969187 -0.5294040172571696 DISEASVFDAYVLPK(ub)LYVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DISEASVFDAYVLPKLYVK 19 1 P62854 P62854 RPS26 40S ribosomal protein S26 1 37626500.0 19695500.0 10196000.0 7735000.0 True False 16377680.90859093 10141072.124252453 9352352.73740084 1.0 0.6192007391555018 0.5710425541686462 23.96522774899609 -13.999999999999998 0.291565205373727 4.310451996262512 0.5581250197394069 0.9996309653788518 0.003685898011248755 16.05955126316436 0.17126987698757198 31.917534275474004 0.018060601279688292 1.0000000000000041e-14 13.999999999999998 -3.752326976523105 DISEASVFDAYVLPK(ub)LYVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DISEASVFDAYVLPKLYVK 19 1 P62854 P62854 RPS26 40S ribosomal protein S26 1 107232100.0 36336000.0 34647100.0 36249000.0 True False 47037668.28964081 32718958.427751366 29652053.94614908 1.0 0.6955905685264829 0.63038953724412 25.48731321013522 -13.999999999999998 0.21656152291042188 2.809734333554135 0.5943431395903137 0.9994946888058707 0.003620989719138322 12.908430128233185 0.14745148616747794 9.972432175751036 0.03692030517064606 1.0000000000000041e-14 13.999999999999998 -2.2153911939638213 DISPVLK(ub)DPASFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DISPVLKDPASFR 13 1 P07741-2;P07741;H3BQB1;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 1 36471200.0 5805500.0 13165200.0 17500500.0 True False 7611066.720541977 11201003.477547672 15689716.136649793 1.0 1.4716732737760125 2.061434581082288 22.85966723653339 -6.968105541923558 0.3000070003222233 0.8977241612229379 2.653863539545704 0.9999636046620983 0.0026195909727740017 0.07692234059421948 0.011218770179726353 0.009783978242778388 0.05289264387980359 1.0762036436349027e-07 6.968105541923558 1.7561393783227661 DISPVLK(ub)DPASFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DISPVLKDPASFR 13 1 P07741-2;P07741;H3BQB1;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 1 55508500.0 12531500.0 13027000.0 29950000.0 True False 12133694.391896307 18228749.03490754 22105196.519259352 1.0 1.5023247204150714 1.8218026435561687 23.532515544379855 -8.844686533887264 0.10840074028354262 4.673782203923202e-15 2.713817952909383 0.9999575847426568 0.002202954065221572 0.3603637211833984 0.03257312398518862 0.44195320445476083 0.334408940270292 1.4299256813143441e-09 8.844686533887264 2.713817952909378 DISPVLK(ub)DPASFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DISPVLKDPASFR 13 1 P07741-2;P07741;H3BQB1;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 1 157099000.0 23800000.0 14598000.0 118701000.0 True False 36106340.01306551 11992872.845305428 95239695.3215034 1.0 0.33215421006298795 2.637755454777188 25.105748850418554 -6.829213862985986 1.3313933388958914 0.6429426208880437 2.6988159232666376 0.9042930862120251 0.29965808913846503 0.18178747281965207 0.6304868486738249 0.17672929762485023 0.40672348197472236 1.4817882170371387e-07 6.829213862985986 2.055873302378594 up DISPVLK(ub)DPASFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DISPVLKDPASFR 13 1 P07741-2;P07741;H3BQB1;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 1 49372700.0 5805500.0 6176200.0 37391000.0 True False 7951950.237738401 5903315.062037816 28560015.8918174 1.0 0.7423732399659442 3.5915737696995573 22.92287729805628 -6.884822193847484 1.0525735138220942 0.8273714507381784 3.813107102232827 0.9773701383157629 0.1935624600660751 0.12344284297556517 0.24721855102470558 0.14098957293338493 0.3455235404097331 1.3037004221432728e-07 6.884822193847484 2.9857356514946485 up DISPVLK(ub)DPASFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DISPVLKDPASFR 13 1 P07741-2;P07741;H3BQB1;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 1 58506400.0 12531500.0 18271900.0 27703000.0 True False 10420497.48957922 18173465.648011807 33495569.21580026 1.0 1.7440113263484558 3.214392522938251 23.31292081981413 -6.960277413270121 0.43150603806185267 0.9425186452920623 4.072412364325245 0.999780350847537 0.013636268252100403 0.0796021667214901 0.020766226187941945 0.019201748111221377 0.12204506962872154 1.0957780249783337e-07 6.960277413270121 3.1298937190331824 DISPVLK(ub)DPASFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DISPVLKDPASFR 13 1 P07741-2;P07741;H3BQB1;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 1 133495900.0 23800000.0 22819900.0 86876000.0 True False 30809569.16813775 21549952.50469571 71065459.42303638 1.0 0.6994564703936842 2.3066034787831424 24.876875172511003 -6.8583607362343795 1.1939137773500907 0.8375819092657801 2.3820548065206046 0.951620201214312 0.15345133166413727 0.14850619043445093 0.4031661473891608 0.10030603716246858 0.23374086398670454 1.3856044318533098e-07 6.8583607362343795 1.5444728972548245 up DISPVLKDPASFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DISPVLKDPASFR 13 1 P07741-2;P07741;H3BQB1;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 0 7902300.0 2266100.0 1312800.0 4323400.0 False True 2194163.895900429 1837007.886161561 3190971.840780161 1.0 0.8372245526388535 1.4542996750343788 21.065239863055943 -6.8365806747190785 1.2981920228021502 0.9133335531826908 1.4732585182938895 0.9184120427064625 0.07458606850750152 0.17283040928986948 0.5672707851738213 0.045075290210565395 0.10376829304218455 1.4568650517500773e-07 6.8365806747190785 0.5599249651111987 DISTLNSGK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 DISTLNSGKK 10 1 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 1 2709570.0 694690.0 871780.0 1143100.0 True False 910745.3173875307 741713.822171824 1024822.9773894671 1.0 0.8144031135942891 1.1252574762933372 19.79668814678296 -6.745012476710432 1.6685939047301912 0.8902156872140253 1.1256374834876604 0.6271377724445 0.07797686640539223 0.3088139275412823 1.6900581144578142 0.036944343077540305 0.09015537844526547 1.7988192366708343e-07 6.745012476710432 0.23542179627363502 DISTLNSGK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 DISTLNSGKK 10 1 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 1 4225070.0 669570.0 1523100.0 2032400.0 True False 648314.8668540881 2131281.772861569 1500053.4693069337 1.0 3.2874177067749435 2.3137730538031 19.30633513094438 -10.652143602246253 6.51803031642669 0.990270792239772 2.800595380288981 0.8201456478938758 0.3974887650950363 0.05531887330116245 0.0029522737426979774 0.3788464001295009 0.12828894729313564 2.2276984247531045e-11 10.652143602246253 1.8103245880492091 DISTLNSGK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DISTLNSGKK 10 1 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 1 3896170.0 669570.0 2070600.0 1156000.0 True False 556777.1219804137 2059445.2668180775 1397714.255259906 1.0 3.698868336207472 2.5103658179925623 19.086740406378656 -9.743435584619396 6.972385174877855 0.999999996402004 3.1046170771001833 0.8069886951248192 0.4852041212738332 2.7302455140036253e-08 6.024210123559156e-09 0.46979686680066235 0.15659895676697436 1.8053624920603516e-10 9.743435584619396 2.1046170806981794 DISTNYYASQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DISTNYYASQK 11 0 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 0 81864000.0 10605000.0 36855000.0 34404000.0 False True 13903257.698966103 31356377.659664832 30844204.106471233 1.0 2.255325934294997 2.218487549775109 23.72891962741088 -10.477638510038297 6.460366272878231 0.999477976088247 2.236906742035053 0.999335186627413 0.015039207503694653 0.00011311784136097516 9.146333742145087e-06 0.014566911715818164 0.004853883350163903 3.3293656153402764e-11 10.477638510038297 1.237428765946806 DISTNYYASQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DISTNYYASQK 11 0 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 0 51715200.0 15786000.0 7517200.0 28412000.0 False True 15284882.070819536 10518857.16168014 20970044.858270306 1.0 0.6881870015707714 1.3719467877547025 23.865602085491037 -6.782699849235665 1.52514670278261 0.8240622946630612 1.377848339620922 0.7768853029557792 0.13202346831975087 0.24640653472421695 1.132213783255685 0.06816533541449277 0.16049629173436303 1.6493018676409118e-07 6.782699849235665 0.5537860449578608 DISTNYYASQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DISTNYYASQK 11 0 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 0 53326000.0 10605000.0 17679000.0 25042000.0 False True 14525955.089349026 16897883.323364966 19127595.356179096 1.0 1.1632889692571835 1.3167874496737337 23.79212968893377 -6.971872539798583 0.20868281273382164 0.9182717466171293 1.5660833754657202 0.9999935346546713 0.0003288443669055465 0.07569971035343309 0.006811760887426831 0.00464500937673555 0.015954980511838714 1.0669092002899566e-07 6.971872539798583 0.6478116288485909 DISTNYYASQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DISTNYYASQK 11 0 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 0 24816800.0 15786000.0 5756400.0 3274400.0 False True 13126758.438375093 5725389.130644064 3959061.90088498 1.0 0.43616168892895285 0.30160240393477183 23.646007360925314 -13.999999999999892 0.20126318221882455 4.1494695155254675 0.21529311637835288 0.9994870273894984 0.006852216081401295 12.55614541818 0.14224573721160047 15.575544362868047 0.08488020979661114 1.0000000000002494e-14 13.999999999999892 -3.934176399147115 DISTTLNADEAVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DISTTLNADEAVAR 14 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;O95757;E9PDE8;D6RJ96 Q92598-2;O95757 HSPH1;HSPA4L Heat shock protein 105 kDa;Heat shock 70 kDa protein 4L 0 14769200.0 1562400.0 6999300.0 6207500.0 False True 2048321.5303031248 5955031.723057711 5565207.446544594 1.0 2.907273899609132 2.7169598933625503 20.96601076599239 -9.96253965609675 6.266239747316541 0.9999994282767607 2.8121168964859455 0.991795493191113 0.0776953677018687 6.20662284585067e-07 1.0286366609416613e-07 0.0752282409530137 0.025076072098845152 1.0900849505080018e-10 9.96253965609675 1.812117468209185 DISTTLNADEAVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DISTTLNADEAVAR 14 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;O95757;E9PDE8;D6RJ96 Q92598-2;O95757 HSPH1;HSPA4L Heat shock protein 105 kDa;Heat shock 70 kDa protein 4L 0 9155800.0 1562400.0 3469200.0 4124200.0 False True 2140061.502272411 3315919.27288974 3150148.900565204 1.0 1.5494504570867482 1.4719898924494639 21.02922082751528 -10.619090456696746 6.339140968923841 0.9980341801207456 1.510720174768106 0.9830399267334318 0.031623143091536896 0.0008812336438752948 5.295194915021214e-05 0.030711480203119337 0.010206325545688026 2.403862061274673e-11 10.619090456696746 0.5126859946473604 DISTTLNADEAVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DISTTLNADEAVAR 14 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;O95757;E9PDE8;D6RJ96 Q92598-2;O95757 HSPH1;HSPA4L Heat shock protein 105 kDa;Heat shock 70 kDa protein 4L 0 3007100.0 0.0 1848900.0 1158200.0 False True 0.0 1838939.608722083 1400374.2650882555 0.0 DITAALFSK(ub)NDGEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DITAALFSKNDGEEK 15 1 Q8N5D0-5;Q8N5D0-3;Q8N5D0-6;Q8N5D0-2;Q8N5D0-4;Q8N5D0 Q8N5D0-5 WDTC1 WD and tetratricopeptide repeats protein 1 1 12074000.0 3919400.0 5082100.0 3072500.0 True False 5138371.35552359 4323870.489870644 2754587.173501131 1.0 0.8414865704913712 0.5360817626659146 22.29287972842474 -6.9607689248426965 0.42446145959144244 1.0128683743218594 0.35309465487033637 0.9997976537263127 0.002738738718253255 0.07942762898435787 0.020125120198029433 0.0039632116971618945 0.025392375361390662 1.0945385827447225e-07 6.9607689248426965 -0.659773719451523 DITAALFSK(ub)NDGEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DITAALFSKNDGEEK 15 1 Q8N5D0-5;Q8N5D0-3;Q8N5D0-6;Q8N5D0-2;Q8N5D0-4;Q8N5D0 Q8N5D0-5 WDTC1 WD and tetratricopeptide repeats protein 1 1 12795800.0 4129400.0 4367100.0 4299300.0 True False 3998314.457319279 6110905.804125644 3173184.3537646653 1.0 1.5283704844522856 0.7936305129667482 21.9309605101848 -6.713747360164986 1.782013105709762 1.323589916672895 0.7951744865146763 0.4827473361299267 0.22252797279265255 0.3676225942386032 2.277935551141107 0.09929240653040283 0.25109411074881155 1.9330925176972823e-07 6.713747360164986 -0.5284154301582188 DITAALFSK(ub)NDGEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DITAALFSKNDGEEK 15 1 Q8N5D0-5;Q8N5D0-3;Q8N5D0-6;Q8N5D0-2;Q8N5D0-4;Q8N5D0 Q8N5D0-5 WDTC1 WD and tetratricopeptide repeats protein 1 1 24353700.0 9022000.0 7939400.0 7392300.0 True False 13687033.596549425 6522552.039184674 5931208.664839815 1.0 0.4765497208123347 0.4333450797063218 23.706306468055235 -13.999999999999998 0.35344080029021707 7.575582080780259 0.42764505175778955 0.9997612095502694 0.003979798342381845 21.007252093715497 0.19162899955659538 103.87871355104224 0.012741269345258823 1.0000000000000041e-14 13.999999999999998 -7.1479370290224695 DITAALFSK(ub)NDGEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DITAALFSKNDGEEK 15 1 Q8N5D0-5;Q8N5D0-3;Q8N5D0-6;Q8N5D0-2;Q8N5D0-4;Q8N5D0 Q8N5D0-5 WDTC1 WD and tetratricopeptide repeats protein 1 1 13735400.0 4129400.0 5588200.0 4017800.0 True False 3433779.063437607 5558095.257429145 4857903.403791733 1.0 1.6186525558999867 1.4147396539043529 21.711365785619076 -10.211904013401343 4.947840415239994 0.9999348618763116 1.5166961049028231 0.8954073954232322 0.083247093645642 5.982784198794914e-05 9.529604446808735e-06 0.08061376885524839 0.0268678839421357 6.138976721847172e-11 10.211904013401343 0.5167612430265115 DITLFHAMDTLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DITLFHAMDTLQR 13 0 O94776;O94776-2 O94776 MTA2 Metastasis-associated protein MTA2 0 1704010.0 593210.0 0.0 1110800.0 False True 777704.0546538115 0.0 995865.0715459893 1.0 0.0 1.280519325554102 19.568861734905486 -6.698382422317683 1.8368966586528048 0.3780362091768176 1.2765596782573667 0.40973303616135215 0.4222419017923696 0.39892560597074184 2.6158353407720485 0.18347256396629827 0.4727421375953284 2.0027077465127281e-07 6.698382422317683 0.8985234690805491 DITLFHAMDTLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DITLFHAMDTLQR 13 0 O94776;O94776-2 O94776 MTA2 Metastasis-associated protein MTA2 0 2961810.0 593210.0 1001900.0 1366700.0 False True 812535.7678974752 957632.7451597569 1043913.6080700409 1.0 1.1785730339449991 1.2847601906452453 19.632071796428377 -12.787377447374102 0.061164602816865046 5.269140501962786e-21 1.7776605472601834 0.999963837827968 0.0007065516355829334 8.138920284597505 0.05386368227291001 1.4478315655539378 0.407440292331837 1.6316332713545022e-13 12.787377447374102 1.7776605472601834 DITSSIHFEAYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DITSSIHFEAYR 12 0 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4 Q9UHD8 SEPT9 Septin-9 0 18516100.0 5252300.0 6499300.0 6764500.0 False True 7968123.0945640225 5339449.135737323 5427493.610014319 1.0 0.6701012361844634 0.6811508238015349 22.92580850419821 -10.00901922857892 5.42389316189802 1.00000129631297 0.6756260299947335 0.9991304704880115 0.004510975256869582 7.462080865111892e-08 1.3631607231590757e-08 0.004367751428033046 0.00145591100347908 9.794466190194626e-11 10.00901922857892 -0.32437526631823654 DITSSIHFEAYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DITSSIHFEAYR 12 0 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4 Q9UHD8 SEPT9 Septin-9 0 21888300.0 5252300.0 7943900.0 8692100.0 False True 6799205.888311332 7501814.9817506885 7110226.988477545 1.0 1.1033369344863093 1.045743739088839 22.696934826290658 -10.147667394748831 4.381391107424578 0.9999870883635747 1.074540336672448 0.6907341990479925 0.023512323580078775 3.156277175810512e-06 6.139856516425959e-07 0.022769905433935565 0.007588569802303209 7.117584064961994e-11 10.147667394748831 0.07455324830887322 DITTK(ub)HDEVVCGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DITTKHDEVVCGR 13 1 B4E1Q4;O14730-2;O14730 B4E1Q4 RIOK3 Serine/threonine-protein kinase RIO3 1 3010880.0 983810.0 867470.0 1159600.0 True False 952579.4900603672 1213855.2947962875 855865.9727456801 1.0 1.2742824168084521 0.8984719718156454 19.861479960880988 -6.711051941444864 1.7916024530811254 1.1684455850358486 0.8993340050772014 0.4699844833142529 0.11556278932632015 0.3729888600627925 2.334482006797795 0.05131952007813498 0.13020246352971 1.9451274312542807e-07 6.711051941444864 -0.2691115799586472 DITTK(ub)HDEVVCGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DITTKHDEVVCGR 13 1 B4E1Q4;O14730-2;O14730 B4E1Q4 RIOK3 Serine/threonine-protein kinase RIO3 1 18876800.0 1189000.0 6284800.0 11403000.0 True False 1803799.9275434818 5163228.336633475 9149192.05188756 1.0 2.8624174210191122 5.072176748752538 20.78260789708154 -6.968860329582627 0.2840897523642842 0.5365383429130799 7.4657710933197725 0.9999720787566019 0.00879517037935664 0.07667425794524203 0.010347543185335739 0.03987902498855657 0.20180211103356435 1.0743348661272617e-07 6.968860329582627 6.929232750406692 DITTK(ub)HDEVVCGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DITTKHDEVVCGR 13 1 B4E1Q4;O14730-2;O14730 B4E1Q4 RIOK3 Serine/threonine-protein kinase RIO3 1 3298470.0 288430.0 550240.0 2459800.0 True False 395070.3655276692 525928.5773996457 1878845.9011712044 1.0 1.3312276072572486 4.755724714157578 18.591750107364103 -6.925657846512322 0.7816103826542391 0.9386984850229715 5.3868589367850035 0.995613839177424 0.1124412755654649 0.09495611045655662 0.08919063723952883 0.09990666918254931 0.31757679823183993 1.1867033093701499e-07 6.925657846512322 4.448160451762032 up DITTK(ub)HDEVVCGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DITTKHDEVVCGR 13 1 B4E1Q4;O14730-2;O14730 B4E1Q4 RIOK3 Serine/threonine-protein kinase RIO3 1 3510840.0 983810.0 937730.0 1589300.0 True False 818081.605172798 932678.2623651682 1921615.281907067 1.0 1.1400797383387744 2.3489286029126357 19.641885236315265 -6.928713833248258 0.757273519457035 0.9807138001184119 2.589163144480072 0.9962794648454482 0.036938083611876435 0.09331086816052274 0.0809916953256486 0.033398623515914556 0.1101633814747357 1.1783821812336477e-07 6.928713833248258 1.60844934436166 up DITTK(ub)HDEVVCGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DITTKHDEVVCGR 13 1 B4E1Q4;O14730-2;O14730 B4E1Q4 RIOK3 Serine/threonine-protein kinase RIO3 1 14773400.0 1189000.0 5703400.0 7881000.0 True False 1539183.9386939397 5386000.776308472 6446738.865888732 1.0 3.499257392770557 4.18841355072809 20.55373421917399 -9.59512443739835 0.367092965832226 8.011368309667956e-20 4.323121546179008 0.9984732029714251 0.05352396519420831 0.9389541817574507 0.1529279748258921 1.3575542730949373 0.19144330077997176 2.540244750782734e-10 9.59512443739835 4.323121546179008 DITVESK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DITVESKR 8 1 Q99598;C4P0D6;C4P0D8;Q5VVQ1;C4P0D4 Q99598 TSNAX;DISC1 Translin-associated protein X 1 15369300.0 4582800.0 5432100.0 5354400.0 True False 6008095.179898329 4621651.854159956 4800378.0510315485 1.0 0.7692374564276069 0.7989850205922973 22.518476237449267 -10.024928911238122 7.105590051900468 1.000000025455098 0.7841112385817124 0.9859601179328413 0.012144392215699282 4.8939369313256255e-09 6.658022465319491e-10 0.011758758602054555 0.003919585733434466 9.44215420298455e-11 10.024928911238122 -0.21588878687338564 DITVESK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DITVESKR 8 1 Q99598;C4P0D6;C4P0D8;Q5VVQ1;C4P0D4 Q99598 TSNAX;DISC1 Translin-associated protein X 1 24852800.0 7836900.0 8528300.0 8487600.0 True False 7588121.899202173 11933694.664496984 6264442.937457955 1.0 1.5726809377893247 0.8255590804513313 22.855311424399588 -6.701941880612747 1.824316678269282 1.354945078031265 0.827727737678803 0.426607452130504 0.24165230464769086 0.3915080949977811 2.534614153997739 0.10563042225273003 0.270966788943065 1.9863607239667572e-07 6.701941880612747 -0.527217340352462 DITVESK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DITVESKR 8 1 Q99598;C4P0D6;C4P0D8;Q5VVQ1;C4P0D4 Q99598 TSNAX;DISC1 Translin-associated protein X 1 31363900.0 13144000.0 6469900.0 11750000.0 True False 19940408.955114827 5315295.795440579 9427607.349792039 1.0 0.26655901628723494 0.472789067215886 24.24919166228596 -10.137288796623567 5.6738165788978385 1.0000080297137648 0.36967404175230306 0.9256815907945906 0.08419306573408945 8.551781315217187e-06 1.3002328273096797e-06 0.08152062305095417 0.02717319512116158 7.289725977206527e-11 10.137288796623567 -0.6303339879614618 DITVESK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DITVESKR 8 1 Q99598;C4P0D6;C4P0D8;Q5VVQ1;C4P0D4 Q99598 TSNAX;DISC1 Translin-associated protein X 1 14340100.0 4582800.0 4278600.0 5478700.0 True False 6277185.005513309 4089557.304561865 4184743.8973683524 1.0 0.6514954236604417 0.6666593216056009 22.58168629897216 -9.97681222541869 7.092944880565909 1.0000000188469549 0.6590773726395405 0.9985184109132085 0.00619063541288107 1.8442358144157657e-09 2.644440136641454e-10 0.005994057321405031 0.0019980189880439863 1.054842877008005e-10 9.97681222541869 -0.3409226462074144 DITVESK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DITVESKR 8 1 Q99598;C4P0D6;C4P0D8;Q5VVQ1;C4P0D4 Q99598 TSNAX;DISC1 Translin-associated protein X 1 23215600.0 7836900.0 10777000.0 4601700.0 True False 6516729.58353615 10718942.161932977 5563894.194143172 1.0 1.6448345791443129 0.853786262391458 22.635716699833864 -6.68995425104843 1.8664413383031688 1.4042876599643048 0.8565134323667208 0.37024424835079484 0.27272234989990346 0.41678390934805987 2.814929630443052 0.1168909350018258 0.30442505804628933 2.0419530344167402e-07 6.68995425104843 -0.547774227597584 DITVESK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DITVESKR 8 1 Q99598;C4P0D6;C4P0D8;Q5VVQ1;C4P0D4 Q99598 TSNAX;DISC1 Translin-associated protein X 1 26815900.0 13144000.0 9232800.0 4439100.0 True False 17015167.106974892 8718986.563716514 3631229.3490123968 1.0 0.5124243863665852 0.21341132450729067 24.02031798437841 -8.503183393009666 0.2584450511503831 1.2254359697977883 1.2270888614837205e-26 0.9992678291482918 0.008771995930386975 0.16585797209917977 0.06861337773154255 0.13243165960570347 0.10777226682054916 3.1391828060802357e-09 8.503183393009666 -1.2254359697977883 down DITVLDLGCGK(ub)GGDLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DITVLDLGCGKGGDLLK 17 1 K7EP06;O43148;O43148-2 K7EP06 RNMT mRNA cap guanine-N7 methyltransferase 1 10680100.0 5040800.0 1411200.0 4228100.0 True False 4191648.545303506 1403597.585498733 5112176.161474392 1.0 0.33485574239552623 1.2196099234517843 21.99908632646577 -6.70559034704141 1.8111953019440732 0.5892389479223539 1.2172457038554014 0.4439616917870365 0.28049140304042186 0.38403679719682876 2.4529761364577785 0.12337849754075998 0.3150949475688852 1.969743395424234e-07 6.70559034704141 0.6280067559330476 DITYFIQQLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DITYFIQQLLR 11 0 P61158;B4DXW1;C9IZN3;Q9P1U1-2;Q9P1U1;A0A0A0MTI9;H7C4J1;Q9C0K3;Q9P1U1-3 P61158;Q9P1U1-2 ACTR3;ACTR3C;ACTR3B Actin-related protein 3;Actin-related protein 3B;Actin-related protein 3C 0 594790000.0 309330000.0 78680000.0 206780000.0 False True 299510488.4686814 110097334.31077972 152618114.73296994 1.0 0.36759091434052454 0.5095584983125845 28.158031284305963 -10.051603464841078 7.4981477203766795 1.0000000434584901 0.4385747063278478 0.9542372547809628 0.05795802345787848 4.209539209951749e-08 5.4088773664222835e-09 0.05611761950703054 0.018705871635955162 8.879664050203542e-11 10.051603464841078 -0.5614253371306424 DITYFIQQLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DITYFIQQLLR 11 0 P61158;B4DXW1;C9IZN3;Q9P1U1-2;Q9P1U1;A0A0A0MTI9;H7C4J1;Q9C0K3;Q9P1U1-3 P61158;Q9P1U1-2 ACTR3;ACTR3C;ACTR3B Actin-related protein 3;Actin-related protein 3B;Actin-related protein 3C 0 621170000.0 309330000.0 124700000.0 187140000.0 False True 257221600.6425038 124028216.34898792 226270108.76240373 1.0 0.4821842957169331 0.8796699351734553 27.93843655974024 -9.823822758906676 6.337645644142696 1.000000011212316 0.6809271154450963 0.4621235936996442 0.16227283279242039 2.5739188212641725e-08 4.8024959335730374e-09 0.15712000176038435 0.052373331578859136 1.500297000836497e-10 9.823822758906676 -0.31907289576721964 DITYFIQQLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DITYFIQQLLR 11 0 P61158;B4DXW1;C9IZN3;Q9P1U1-2;Q9P1U1;A0A0A0MTI9;H7C4J1;Q9C0K3;Q9P1U1-3 P61158;Q9P1U1-2 ACTR3;ACTR3C;ACTR3B Actin-related protein 3;Actin-related protein 3B;Actin-related protein 3C 0 4675720000.0 2812100000.0 999000000.0 864620000.0 False True 3640318884.7781587 943404771.8084233 707268031.7503777 1.0 0.2591544317046594 0.19428738364317186 31.761417687195284 -13.999999999999998 0.3448161264196567 9.824826769012233 0.18470071345634587 0.9997447093911649 0.00583969577414073 20.154603328547694 0.18867335409370387 129.95170432415136 0.019703601802399964 1.0000000000000041e-14 13.999999999999998 -9.640126055555887 DIVENICGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIVENICGR 9 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 0 4536550.0 951850.0 1317900.0 2266800.0 False True 1247884.567728512 1121274.4571339649 2032253.2806809952 1.0 0.898540206467164 1.6285587090641298 20.251053056995673 -6.871750208605715 1.12485303167852 0.9419686414695062 1.6727479576087063 0.9663961061450017 0.05918968916956365 0.13518483223657776 0.3186299134787435 0.04079371611611317 0.09688110164851826 1.3435374959566216e-07 6.871750208605715 0.7307793161392001 DIVHK(ub)PGPIVLTVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIVHKPGPIVLTVAK 15 1 I3L2N2;O14641;I3L0M7;I3L0Z8;I3L2W9 I3L2N2 DVL2 Segment polarity protein dishevelled homolog DVL-2 1 16172800.0 2622400.0 5547500.0 8002900.0 True False 2539153.3474291833 7762645.679830321 5906700.408146271 1.0 3.0571787590890356 2.3262480047243415 21.275916095816086 -10.238120852207079 5.574442234258634 0.9999042198559853 2.691713381906754 0.8771850126272345 0.29840123091707876 0.0003552247257982166 4.8549681061938595e-05 0.28894166581533803 0.09630858315243643 5.779352015593981e-11 10.238120852207079 1.6918091620507685 DIVHK(ub)PGPIVLTVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIVHKPGPIVLTVAK 15 1 I3L2N2;O14641;I3L0M7;I3L0Z8;I3L2W9 I3L2N2 DVL2 Segment polarity protein dishevelled homolog DVL-2 1 45520500.0 5638800.0 9408700.0 30473000.0 True False 8554471.851498898 7729643.9744913755 24449998.19320965 1.0 0.9035793335548824 2.8581540295705774 23.028247355570794 -6.895299506048567 0.9905186093882099 0.907927370408728 3.0448031130686717 0.984078697172509 0.11350243517723872 0.11494800411541987 0.19757944585257994 0.08664604945807866 0.22056248660659095 1.2726251274616212e-07 6.895299506048567 2.1368757426599436 up DIVHK(ub)PGPIVLTVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIVHKPGPIVLTVAK 15 1 I3L2N2;O14641;I3L0M7;I3L0Z8;I3L2W9 I3L2N2 DVL2 Segment polarity protein dishevelled homolog DVL-2 1 13783400.0 2622400.0 6063300.0 5097700.0 True False 2180641.792017914 6030635.7994291745 6163605.500898279 1.0 2.7655325241880133 2.826509848366533 21.056321371250363 -10.591282256542712 0.6349075397699203 2.207057375015075e-18 2.817995390203306 0.9998881566221545 0.00895772845012043 2.0569352274657615 0.31413208964245154 3.307194826692214 0.010151528773447582 2.562817869298538e-11 10.591282256542712 2.817995390203306 DIVHK(ub)PGPIVLTVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIVHKPGPIVLTVAK 15 1 I3L2N2;O14641;I3L0M7;I3L0Z8;I3L2W9 I3L2N2 DVL2 Segment polarity protein dishevelled homolog DVL-2 1 37883800.0 5638800.0 13484000.0 18761000.0 True False 7299537.757365341 12733603.54661138 15346690.504116064 1.0 1.7444397124685034 2.1024194975402417 22.799373677663244 -9.97191873097494 0.17456908400961887 3.066450430500128e-17 2.5160879900174535 0.9995886377724121 0.009313245935513728 1.5088756296754826 0.08009210013620158 0.9649651781831986 0.2569562310633914 1.066795730806945e-10 9.97191873097494 2.5160879900174535 DIVINANPASPPLSLLVLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIVINANPASPPLSLLVLHR 20 0 A8MU58;Q13155-2;Q13155 A8MU58 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 0 13058800.0 5416900.0 3690200.0 3951700.0 False True 5244943.474561148 5163716.104138776 2916631.221541139 1.0 0.9845132038474125 0.5560843955110837 22.322495794098167 -6.914555122173575 0.864130555813182 1.0114314719414876 0.49496190780366006 0.9925301601242341 0.017779214669718622 0.10148257865879282 0.12299548795132058 0.014892207377329861 0.042530617246713656 1.217432462255442e-07 6.914555122173575 -0.5164695641378276 DIVINANPASPPLSLLVLHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIVINANPASPPLSLLVLHR 20 0 A8MU58;Q13155-2;Q13155 A8MU58 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 0 50005900.0 12638000.0 16991000.0 20376900.0 False True 19172769.961559724 13958823.298711076 16349396.783487469 1.0 0.7280545965292284 0.8527404655804586 24.192555447806964 -10.148600808912942 5.032299293035331 1.0000108868146154 0.7903975310544638 0.7902631712050852 0.050902792886483875 6.21777600620485e-06 1.0519876911313608e-06 0.04928897642408114 0.016428805760211003 7.102302914311692e-11 10.148600808912942 -0.2096133557601516 DIVINANPASPPLSLLVLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIVINANPASPPLSLLVLHR 20 0 A8MU58;Q13155-2;Q13155 A8MU58 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 0 16201960.0 5416900.0 2821960.0 7963100.0 False True 4504392.359358544 2806757.541364799 9628147.392785585 1.0 0.623115687409722 2.1375019369220083 22.102901069532443 -6.84082837862184 1.2786032567870012 0.7995288506382537 2.188114492054635 0.925860462251714 0.1752743639103445 0.16783304605848887 0.5326329361665011 0.10747773400748285 0.24765696778264573 1.4426853489415051e-07 6.84082837862184 1.3885856414163813 up DIVINANPASPPLSLLVLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIVINANPASPPLSLLVLHR 20 0 A8MU58;Q13155-2;Q13155 A8MU58 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 0 30426500.0 12638000.0 8929100.0 8859400.0 False True 16360140.132223718 8432187.735690275 7247080.1051205 1.0 0.5154104835008004 0.44297176225564855 23.963681769899413 -13.999999999999998 0.2676153846006017 4.692811476999407 0.4183655206821047 0.9995782267352218 0.005078545851106726 14.767528409749955 0.16374260583352834 29.626832213194437 0.03044825784499525 1.0000000000000041e-14 13.999999999999998 -4.274445956317302 DIVISVGIYNLVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIVISVGIYNLVQK 14 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 14528600.0 5656300.0 8872300.0 0.0 False True 8581020.630920254 7288968.745403705 0.0 1.0 0.8494291132617886 0.0 23.03271782213014 -7.179012707870942 0.910775862791881 0.9919239172097202 4.340268385822894e-19 0.9895257737482214 0.04505448541517618 0.0906036993050986 0.14252188135445748 0.03785956469257928 0.06645097539939168 6.62197126898474e-08 7.179012707870942 -0.9919239172097202 down DIVQFVPFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIVQFVPFR 9 0 O75131;E7ENV7;O95741;O95741-2;Q9HCH3;Q96A23-2;Q86YQ8;Q9UBL6-2;Q96FN4;Q96A23;Q8IYJ1;Q96FN4-2;Q9HCH3-2;Q86YQ8-2;Q9UBL6 O75131 CPNE3;CPNE8;CPNE6;CPNE5;CPNE4;CPNE7;CPNE2;CPNE9 Copine-3;Copine-6;Copine-5;Copine-4;Copine-8;Copine-7;Copine-2;Copine-9 0 23906600.0 5264900.0 7049700.0 11592000.0 False True 6902334.885364125 5997912.239515376 10392571.03831572 1.0 0.8689685938353255 1.50566021656706 22.7186530410306 -6.853050678894382 1.2201955908992126 0.9298467894254767 1.5326626507670573 0.9446381603851971 0.06459143978654935 0.1541332319323638 0.44006291518655866 0.04138578668374972 0.09597987699206809 1.402650016321183e-07 6.853050678894382 0.6028158613415806 DIVQFVPFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIVQFVPFR 9 0 O75131;E7ENV7;O95741;O95741-2;Q9HCH3;Q96A23-2;Q86YQ8;Q9UBL6-2;Q96FN4;Q96A23;Q8IYJ1;Q96FN4-2;Q9HCH3-2;Q86YQ8-2;Q9UBL6 O75131 CPNE3;CPNE8;CPNE6;CPNE5;CPNE4;CPNE7;CPNE2;CPNE9 Copine-3;Copine-6;Copine-5;Copine-4;Copine-8;Copine-7;Copine-2;Copine-9 0 27969900.0 5264900.0 9325000.0 13380000.0 False True 7211475.80857271 8912990.666348668 10219919.569749873 1.0 1.2359454434768078 1.4171744925776286 22.78186310255349 -6.974061983465537 0.1282118744293935 0.7117661338424773 1.9460380521614338 0.999999264727285 0.00014634242679048738 0.07500527509614549 0.0038433359011622228 0.011629846877942454 0.02498677344570465 1.0615440404817379e-07 6.974061983465537 1.2342719183189566 DIVSGLK(ub)YVQHTYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIVSGLKYVQHTYR 14 1 P52566;F5H3P3;H0YGX7 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 26393200.0 8981500.0 8718200.0 8693500.0 True False 12302203.265911182 8333001.096767937 6640274.348252645 1.0 0.6773584305713989 0.5397630168128117 23.552413382714843 -13.999999999999998 0.11642242614176779 2.5427590948033867 0.3091800628539107 0.9997106614117 0.0032809923000625832 11.97889538005239 0.10453084469535326 4.297503229387849 0.20461018173408957 1.0000000000000041e-14 13.999999999999998 -2.233579031949476 DIYAYLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIYAYLR 7 0 P14635;P14635-2;E9PC90;D6RHI0 P14635 CCNB1 G2/mitotic-specific cyclin-B1 0 7650100.0 2184100.0 1792500.0 3673500.0 False True 2863376.250854489 1525065.9871102732 3293401.4587002075 1.0 0.5326111043406059 1.1501811743103585 21.449285823865797 -6.704314840534543 1.8156279539185065 0.7110038398476403 1.14849159727578 0.4380207041492674 0.19713944985831386 0.3866080294807284 2.48063124140334 0.08652883286906854 0.22133971938257008 1.9755369610329814e-07 6.704314840534543 0.43748775742813983 DIYDK(ub)YGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DIYDKYGK 8 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;O75190-4;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 80819000.0 21610000.0 19605000.0 39604000.0 True False 28330919.27153769 16680010.419691443 35506157.98839342 1.0 0.5887564134372728 1.2532652981742192 24.75587407873983 -6.739326273630518 1.6893243487536802 0.7551155518786216 1.2535843623461311 0.6018186601926584 0.1727899701025974 0.319049860243652 1.7875625652205884 0.0809275599587042 0.1987236286055307 1.8225259736766945e-07 6.739326273630518 0.49846881046750957 DIYDK(ub)YGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DIYDKYGK 8 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;O75190-4;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 130233000.0 22979000.0 29086000.0 78168000.0 True False 22249544.223068673 40700191.48148621 57693455.81026595 1.0 1.8292595602604578 2.593017422372566 24.407272447308397 -6.972110946042716 0.2014833869477246 0.5540040244228657 3.8893942821864216 0.9999945043815063 0.0015250090396822027 0.07562352356448207 0.0065175371702419 0.024496650771420537 0.08078058458402616 1.0663236805016666e-07 6.972110946042716 3.3353902577635557 DIYDK(ub)YGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DIYDKYGK 8 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;O75190-4;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 226984000.0 64878000.0 85923000.0 76183000.0 True False 98424669.2171287 70589369.33053695 61125396.65780496 1.0 0.7171918370872451 0.6210373592717892 26.55251662303492 -13.999999999999998 0.15060643001069035 2.368787817483816 0.5159823923330353 0.9995642272032587 0.0033576533722973817 11.96003447680678 0.12225210480612789 4.7899894418549005 0.09474635623943979 1.0000000000000041e-14 13.999999999999998 -1.8528054251507806 DIYDK(ub)YGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DIYDKYGK 8 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;O75190-4;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 81617000.0 21610000.0 18441000.0 41566000.0 True False 29599800.988291577 17626215.643767904 31748966.878641475 1.0 0.5954842618955474 1.0726074439216675 24.81908414026272 -6.682076618070864 1.8947496526765535 0.7445288635437036 1.0708097317136003 0.3335006892193191 0.17136744281284247 0.4339532941378339 3.0139249659684144 0.07252914727456293 0.19076651573446743 2.0793298201503836e-07 6.682076618070864 0.32628086816989665 DIYDK(ub)YGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DIYDKYGK 8 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;O75190-4;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 108632000.0 22979000.0 40261000.0 45392000.0 True False 19108056.64230465 40044106.00181724 54883257.33110512 1.0 2.0956660717218525 2.8722574125929308 24.187677722742674 -7.901968245964695 0.1651005579697742 9.560802914842579e-18 4.255433534740681 0.9999361858674803 0.006135363901332086 0.120744553462236 0.026132286928498026 0.254699062575481 0.34104534844439083 1.2532328034228699e-08 7.901968245964695 4.255433534740681 DIYDK(ub)YGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DIYDKYGK 8 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;O75190-4;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 202810000.0 64878000.0 67684000.0 70248000.0 True False 83985849.9365731 63917325.9009822 57463584.80534852 1.0 0.7610487474884539 0.6842055518726733 26.323642945127368 -13.999999999999998 0.15870349310488266 2.173634279770645 0.6075737586271263 0.9995398369656077 0.0028844687108137627 12.00134651423598 0.12584823577053109 4.336216302979848 0.06973144358396462 1.0000000000000041e-14 13.999999999999998 -1.5660605211435188 DK(ub)AKEEELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKAKEEELR 9 2 Q07666;Q07666-2;Q5VWX1;E5RG12;H0YAQ1;H0YAQ3;E5RJZ9;O75525-2;O75525 Q07666 KHDRBS1;KHDRBS2;KHDRBS3 KH domain-containing, RNA-binding, signal transduction-associated protein 1;KH domain-containing, RNA-binding, signal transduction-associated protein 2;KH domain-containing, RNA-binding, signal transduction-associated protein 3 1 3060700.0 1029900.0 1074500.0 956300.0 True False 1350208.8735657886 914188.7883681946 857351.2494773412 1.0 0.6770721228885858 0.634976755272796 20.36475117478401 -13.999999999999998 0.2872147048221669 3.7394589570417023 0.6231802746272009 0.9996212321952398 0.003173457164215276 15.802244691992167 0.16989433396531398 25.5364278432489 0.01610097156409577 1.0000000000000041e-14 13.999999999999998 -3.1162786824145012 DK(ub)AKEEELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKAKEEELR 9 2 Q07666;Q07666-2;Q5VWX1;E5RG12;H0YAQ1;H0YAQ3;E5RJZ9;O75525-2;O75525 Q07666 KHDRBS1;KHDRBS2;KHDRBS3 KH domain-containing, RNA-binding, signal transduction-associated protein 1;KH domain-containing, RNA-binding, signal transduction-associated protein 2;KH domain-containing, RNA-binding, signal transduction-associated protein 3 1 3095180.0 936500.0 1261400.0 897280.0 True False 906771.3201141834 1765083.598114102 662255.4501769964 1.0 1.9465586956277325 0.7303445041618688 19.790379235847038 -6.699009745837203 1.8345792970868722 1.5883455664525248 0.7340485252894916 0.41282970385507567 0.39962666891207427 0.39756891365542896 2.600788194799146 0.17383359349394834 0.4475717868644269 1.9998169919970937e-07 6.699009745837203 -0.8542970411630332 DK(ub)AKEEELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKAKEEELR 9 2 Q07666;Q07666-2;Q5VWX1;E5RG12;H0YAQ1;H0YAQ3;E5RJZ9;O75525-2;O75525 Q07666 KHDRBS1;KHDRBS2;KHDRBS3 KH domain-containing, RNA-binding, signal transduction-associated protein 1;KH domain-containing, RNA-binding, signal transduction-associated protein 2;KH domain-containing, RNA-binding, signal transduction-associated protein 3 1 3295300.0 1029900.0 1228200.0 1037200.0 True False 1410681.862000996 1173934.0628857294 792234.721804527 1.0 0.8321749180361266 0.5615970142841232 20.427961236306903 -6.964030235556986 0.3743258001510652 1.0198135223512732 0.3644756730965942 0.9998917329951865 0.0018792483258968742 0.07829164537248733 0.01603001383091944 0.003544695146517358 0.022927939514437782 1.0863499893601568e-07 6.964030235556986 -0.6553378492546791 DK(ub)AKEEELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKAKEEELR 9 2 Q07666;Q07666-2;Q5VWX1;E5RG12;H0YAQ1;H0YAQ3;E5RJZ9;O75525-2;O75525 Q07666 KHDRBS1;KHDRBS2;KHDRBS3 KH domain-containing, RNA-binding, signal transduction-associated protein 1;KH domain-containing, RNA-binding, signal transduction-associated protein 2;KH domain-containing, RNA-binding, signal transduction-associated protein 3 1 2628440.0 936500.0 1132600.0 559340.0 True False 778741.243984434 1126498.4589965034 676295.4079040443 1.0 1.4465632425383912 0.8684468854426856 19.570784511281314 -6.7003807033836225 1.8290678418694524 1.2771796987734372 0.8701263041618267 0.4196528406850266 0.18848474146382796 0.39469593399847724 2.567307272087925 0.08219478395996452 0.21131887203766447 1.9935140305474943e-07 6.7003807033836225 -0.4070533946116105 DK(ub)ALQDYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKALQDYR 8 1 A0A087X2I1;P62333;H0YJC0;H0YJS8;H0YJE9;H0YJT1;H0YJD2;H0YJY8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 16499400.0 5206000.0 6745100.0 4548300.0 True False 6825116.414975716 5738757.372193878 4077685.5463743475 1.0 0.8408292288761343 0.5974528928806346 22.702422223397072 -6.964936779357306 0.3591364847458672 1.0211797026411045 0.4087733851102894 0.999911834207381 0.001554291646136687 0.07798242399818554 0.01493568566759349 0.003271039478450264 0.02079819364008163 1.0840847137330866e-07 6.964936779357306 -0.6124063175308151 DK(ub)ALQDYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKALQDYR 8 1 A0A087X2I1;P62333;H0YJC0;H0YJS8;H0YJE9;H0YJT1;H0YJD2;H0YJY8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 33304400.0 11131000.0 13252000.0 8921400.0 True False 10777652.49780135 18543592.708267074 6584617.703736906 1.0 1.7205595292713307 0.6109510122988446 23.36153964020651 -6.731365325849123 1.7177740019204328 1.4329383195286816 0.6113783653618611 0.5658898855302575 0.30287308869163176 0.33363603098272415 1.9292017814822342 0.13967600015154652 0.34612531463950136 1.856242338515174e-07 6.731365325849123 -0.8215599541668205 DK(ub)ALQDYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKALQDYR 8 1 A0A087X2I1;P62333;H0YJC0;H0YJS8;H0YJE9;H0YJT1;H0YJD2;H0YJY8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 33766000.0 10875000.0 10656000.0 12235000.0 True False 16498170.068995237 8754353.544291997 9816746.887209 1.0 0.5306257304707945 0.5950203474782615 23.975802677846698 -10.451782275769856 6.053822473208438 1.0002098188428914 0.5628230389746556 0.9839883591370131 0.02628899230837386 7.44825477264814e-05 6.744930819530362e-06 0.02546620471502523 0.008484735783242197 3.53360274994495e-11 10.451782275769856 -0.4373867798682358 DK(ub)ALQDYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKALQDYR 8 1 A0A087X2I1;P62333;H0YJC0;H0YJS8;H0YJE9;H0YJT1;H0YJD2;H0YJY8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 15480000.0 5206000.0 5530100.0 4743900.0 True False 7130798.886860062 5285761.896404808 3623488.5236873226 1.0 0.7412580245594771 0.5081462233305069 22.765632284919963 -6.972363915374941 0.19356797922983818 1.1508099801443643 0.09220216994737006 0.9999954275548778 0.0004295283801466625 0.07554285406373902 0.006201426564533967 0.007984696127206318 0.025165789000431493 1.06570274550422e-07 6.972363915374941 -1.0586078101969942 DK(ub)ALQDYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKALQDYR 8 1 A0A087X2I1;P62333;H0YJC0;H0YJS8;H0YJE9;H0YJT1;H0YJD2;H0YJY8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 33373500.0 11131000.0 16288000.0 5954500.0 True False 9255919.68690948 16200253.311085114 7199558.419502681 1.0 1.750258630052388 0.7778328532479509 23.141944915640785 -6.700639485524687 1.8283924523452186 1.4655791392306539 0.7806703788083109 0.4207203858600683 0.3166553444782963 0.3941844295834188 2.5623241177725538 0.1381365757362702 0.3549965779358598 1.9923265133646192e-07 6.700639485524687 -0.6849087604223429 DK(ub)ALQDYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKALQDYR 8 1 A0A087X2I1;P62333;H0YJC0;H0YJS8;H0YJE9;H0YJT1;H0YJD2;H0YJY8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 30981400.0 10875000.0 14534000.0 5572400.0 True False 14077901.878298208 13725170.123587212 4558280.377652384 1.0 0.9749442951257709 0.3237897534063085 23.746928999939147 -6.915024924883429 0.8608220084298148 1.0171007169290294 0.2299290136680363 0.9926834417746727 0.02677561411237261 0.10118825625387383 0.12143992609664633 0.022481453696590846 0.06444724433641313 1.2161162037097067e-07 6.915024924883429 -0.7871717032609931 down DK(ub)APVQPQQSPAAAPGGTDEKPSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKAPVQPQQSPAAAPGGTDEKPSGK 25 2 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 32626000.0 10545000.0 14237000.0 7844000.0 True False 10210254.74704116 19921908.344974197 5789421.0850440785 1.0 1.9511666298774168 0.5670202388164507 23.283515526285044 -6.721760994136736 1.7528323683438047 1.5775822303356923 0.5689390118496671 0.520876897563158 0.4001703201164318 0.3519088663762593 2.113942874389737 0.18120097907960986 0.4539679028292539 1.897750025193568e-07 6.721760994136736 -1.0086432184860252 DK(ub)APVQPQQSPAAAPGGTDEKPSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKAPVQPQQSPAAAPGGTDEKPSGK 25 2 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 42419100.0 10545000.0 26724000.0 5150100.0 True False 8768634.722707788 26580032.50770131 6226962.098628056 1.0 3.031262374160489 0.7101404375418146 23.06392080171932 -6.675496431878648 1.9173791856802906 2.2904128754320157 0.7191861508660089 0.30359794116080063 0.8617698146793847 0.44876602265978044 3.1855542942363257 0.3611227033991579 0.9581458546460588 2.1110745401210145e-07 6.675496431878648 -1.5712267245660068 DK(ub)APVQPQQSPAAAPGGTDEKPSGK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKAPVQPQQSPAAAPGGTDEKPSGKER 27 3 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 2 5772200.0 1986200.0 2154800.0 1631200.0 True False 2603927.434388158 1833312.2393446148 1462419.0715752782 1.0 0.7040565782031427 0.5616205168631749 21.312257813715945 -13.9999999997782 0.09663358827187572 2.4771312553652445 0.241769219250999 0.9998104544804035 0.0025137905364295216 12.1069057791918 0.09187753078268068 3.5986287257121097 0.2858687922856534 1.0000000005107122e-14 13.9999999997782 -2.2353620361142457 DK(ub)APVQPQQSPAAAPGGTDEKPSGK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKAPVQPQQSPAAAPGGTDEKPSGKER 27 3 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 2 14857900.0 7426800.0 4157400.0 3273700.0 True False 11266998.571808178 3415479.48808554 2626651.7600863148 1.0 0.3031401367735692 0.2331279038819278 23.42559990977732 -13.999999999999998 0.32480148271207243 8.352689179108744 0.21996118550605373 0.9997039516841841 0.005956507545067485 18.393606973813053 0.18197707721223277 92.13654428031224 0.022880662425128196 1.0000000000000041e-14 13.999999999999998 -8.132727993602689 DK(ub)APVQPQQSPAAAPGGTDEKPSGK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKAPVQPQQSPAAAPGGTDEKPSGKER 27 3 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 2 5883400.0 1986200.0 2436300.0 1460900.0 True False 2720551.8150367728 2328656.2102332697 1115865.5081799394 1.0 0.8559499574176623 0.41016146136693105 21.375467875238837 -6.95074995592054 0.5505475270416054 1.0061452023751345 0.23900400227389104 0.9992588380101557 0.006835573618398478 0.08318596168633607 0.034726649674624195 0.007413960581820531 0.03698577212141323 1.1200825829064849e-07 6.95074995592054 -0.7671412001012434 down DK(ub)AVESLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKAVESLR 8 1 P30153;C9J9C1;E9PNM7;P30154;P30154-2;P30154-4;P30154-3 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 24314700.0 5094000.0 5585700.0 13635000.0 True False 6678283.330366171 4752335.332888068 12224180.996155536 1.0 0.7116103192686041 1.8304376126978852 22.671045871267154 -6.838286086592742 1.2902592354063962 0.8465294223197334 1.8660220094621385 0.9214791138971167 0.13290389610403258 0.17080950294305758 0.5530972440456541 0.08079039472737436 0.186056132735674 1.451155370427122e-07 6.838286086592742 1.019492587142405 DK(ub)AVESLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKAVESLR 8 1 P30153;C9J9C1;E9PNM7;P30154;P30154-2;P30154-4;P30154-3 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 36064900.0 4465600.0 6232300.0 25367000.0 True False 4323841.972345857 8720889.891015155 18722621.706312265 1.0 2.0169307636106146 4.330089264607072 22.043882365782697 -6.957452592844246 0.46996050017668667 0.9388796616800806 5.502962357559234 0.9996637425797766 0.025551424942585093 0.08062396271605884 0.024591039462715597 0.031980813067384865 0.1909182318847849 1.1029286218753338e-07 6.957452592844246 4.564082695879153 DK(ub)AVESLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKAVESLR 8 1 P30153;C9J9C1;E9PNM7;P30154;P30154-2;P30154-4;P30154-3 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 29718300.0 5094000.0 5431300.0 19193000.0 True False 6977389.460173866 5191327.207092709 14660008.692242837 1.0 0.7440214190026522 2.1010735857472875 22.734255932790045 -6.857905641823308 1.1962087705736797 0.8618066114529931 2.1642262898723903 0.9510448361279209 0.13026237993347228 0.14898207329368013 0.4062714820777102 0.08499963050367863 0.19797827362157466 1.3870571588978124e-07 6.857905641823308 1.302419678419397 up DK(ub)AVESLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKAVESLR 8 1 P30153;C9J9C1;E9PNM7;P30154;P30154-2;P30154-4;P30154-3 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 37091000.0 4465600.0 8369400.0 24256000.0 True False 3713344.2596229445 8324312.381004166 29327817.452927526 1.0 2.2417292335425487 7.897952735442173 21.824287641216973 -6.941903330673331 0.6416114495997505 0.9380064286908696 9.512640490271938 0.9984027343102871 0.11998361664649577 0.08690893239950782 0.05073513635872014 0.11855391598845039 0.4828845426889434 1.1431327556506921e-07 6.941903330673331 8.574634061581069 DK(ub)DNTNVNADVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKDNTNVNADVQK 13 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 111901600.0 19455700.0 30039900.0 62406000.0 True False 25506611.1092668 25558064.014613103 55948825.760622166 1.0 1.0020172380064873 2.1935029126740955 24.604367894761733 -6.9072678204990385 0.9141363202956421 0.9598463765687267 2.3388137827657998 0.9898491085176604 0.05663730878286247 0.1062526763813757 0.1487715294836951 0.04575221374837537 0.12402974711831934 1.2380328815895926e-07 6.9072678204990385 1.3789674061970731 up DK(ub)DNTNVNADVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKDNTNVNADVQK 13 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 169727000.0 34608000.0 41703000.0 93416000.0 True False 33509387.98346143 58355225.37827197 68947547.18007118 1.0 1.7414590026852539 2.057559129820582 24.99806200156597 -10.310431102366344 0.19008446579015795 7.833059453616214e-21 2.3563193627332546 0.9994579453791268 0.010319415414083367 1.9608565420454327 0.09392420734302039 1.1598559209704908 0.2066431660657581 4.8929288170393224e-11 10.310431102366344 2.3563193627332546 DK(ub)DNTNVNADVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKDNTNVNADVQK 13 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 277702000.0 49587000.0 159831000.0 68284000.0 True False 75227104.29528902 131307909.28469707 54787637.47005958 1.0 1.7454866901333064 0.7282965093937633 26.164749222219697 -6.710279273686554 1.794281450849694 1.4581851167138482 0.7306766690110125 0.4663625009271902 0.3141312011482526 0.37453222875309367 2.3506647263795637 0.1393149488493781 0.3537960927954969 1.948591152463448e-07 6.710279273686554 -0.7275084477028357 DK(ub)DNTNVNADVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKDNTNVNADVQK 13 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 115101400.0 19455700.0 28888700.0 66757000.0 True False 26648998.060523096 27612301.711844184 50990371.503571875 1.0 1.0361478374959279 1.913406702487147 24.667577956284624 -6.915567670610276 0.8569567613186214 0.9773832707445991 2.041391490822245 0.9928584774618562 0.03568937440762102 0.10085035172736417 0.11964791484586318 0.03004894294285577 0.08652625345182215 1.2145973503993921e-07 6.915567670610276 1.064008220077646 DK(ub)DNTNVNADVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKDNTNVNADVQK 13 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 120255100.0 34608000.0 55509000.0 30138100.0 True False 28778085.3943548 55209961.9993262 36439837.36716997 1.0 1.9184723807288568 1.2662356396481511 24.778467277000246 -10.229715567786137 5.759942090328948 0.9999783335617368 1.5923540101885139 0.5237510546631109 0.26627453452395405 7.40893509796794e-05 9.908146331104293e-06 0.2578286159164577 0.08593973647752876 5.892294326777831e-11 10.229715567786137 0.592375676626777 DK(ub)DNTNVNADVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKDNTNVNADVQK 13 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 271367000.0 49587000.0 182114000.0 39666000.0 True False 64191349.0059011 171979195.808928 32447195.007529877 1.0 2.679164692318867 0.5054761351805679 25.935875544312147 -6.7004271197909775 1.8294257904186277 2.0422529370347466 0.5119045811969013 0.41959599248983037 0.7087396765099012 0.39462059055511256 2.5679776821636273 0.30904001412092763 0.7943271708302564 1.9933009796832778e-07 6.7004271197909775 -1.5303483558378455 DK(ub)DNTNVNADVQK(ub)LQQQLQDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKDNTNVNADVQKLQQQLQDIK 22 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 93480600.0 7932600.0 15336000.0 70212000.0 True False 7680783.955085703 21459744.776183467 51821370.88514978 1.0 2.793952401430879 6.7468856288865044 22.872822139436376 -6.95810652347344 0.4613447356744641 0.8863133633487416 8.814234973784837 0.9996933995417095 0.042036441764678606 0.0803845637172643 0.023683861439689216 0.05380906699707684 0.3265051703468412 1.1012691578150332e-07 6.95810652347344 7.927921610436095 DK(ub)DNTNVNADVQK(ub)LQQQLQDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKDNTNVNADVQKLQQQLQDIK 22 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 106121600.0 7690600.0 60490000.0 37941000.0 True False 11667202.45817149 49695086.88947284 30441944.719868947 1.0 4.259383264123212 2.6091897204156234 23.475955339776373 -9.293660117720783 12.410269782016671 0.9999346755704188 3.4342864922694676 0.743683835378813 0.6736886942088276 0.0 0.0 0.6522962728227363 0.21743209094091207 5.085572877973683e-10 9.293660117720783 2.4343518166990488 DK(ub)DNTNVNADVQK(ub)LQQQLQDIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKDNTNVNADVQKLQQQLQDIK 22 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 48689900.0 7932600.0 18031600.0 22725700.0 True False 6596308.373764991 17934460.19180762 27477538.79823532 1.0 2.7188632149365577 4.165593426092646 22.653227414870653 -7.3039979078534785 0.19876532388883436 2.671266203708134e-21 6.445802146830329 0.9999790331422106 0.005924889246706408 0.11138788804005952 0.012760016938451272 0.1100327153556345 0.2666495059401306 4.965947137128301e-08 7.3039979078534785 6.445802146830329 DK(ub)DNTNVNADVQK(ub)LQQQLQDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKDNTNVNADVQKLQQQLQDIK 22 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 85705800.0 7690600.0 57244000.0 20771200.0 True False 9955633.304389918 54058321.078479886 16991054.73050986 1.0 5.429922881414583 1.706677436885676 23.247081661868823 -6.603566188269848 2.1770748620921636 3.97235831815504 1.7191503312765566 0.030867961557943024 1.9130279285324236 0.6307720937820107 5.6552347041848 0.7279617624714027 2.126828387396397 2.4913446511213256e-07 6.603566188269848 -2.2532079868784836 DK(ub)EAIQAYSESLMTSAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKEAIQAYSESLMTSAPK 18 1 Q8WTV0-4;Q8WTV0-2;B7ZKQ9;Q8WTV0-3 Q8WTV0-4 SCARB1 Scavenger receptor class B member 1 1 25661500.0 9020900.0 10508000.0 6132600.0 True False 11826487.25851986 8940247.359863192 5498057.38005306 1.0 0.7559512105695284 0.46489352754278174 23.49551828757071 -6.968787588238252 0.28566406931538396 1.0599022169529466 0.15200403991968528 0.9999713199251531 0.001171405724949712 0.07669809859604386 0.010431527231836138 0.005206744960309794 0.026529707106160583 1.0745148249127576e-07 6.968787588238252 -0.9078981770332614 down DK(ub)EAIQAYSESLMTSAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKEAIQAYSESLMTSAPK 18 1 Q8WTV0-4;Q8WTV0-2;B7ZKQ9;Q8WTV0-3 Q8WTV0-4 SCARB1 Scavenger receptor class B member 1 1 26838900.0 8478300.0 7790600.0 10570000.0 True False 8209161.0072867945 10901427.207442291 7801399.906797039 1.0 1.327958752150887 0.9503285292945516 22.968803352535808 -6.677103385255406 1.9121508671090397 1.2080465800056122 0.9517979905784177 0.3108211009051529 0.13908687400368785 0.4450558925153459 3.1435810127417563 0.0584197090524886 0.15465377813677852 2.1032776878707766e-07 6.677103385255406 -0.2562485894271944 DK(ub)EAIQAYSESLMTSAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKEAIQAYSESLMTSAPK 18 1 Q8WTV0-4;Q8WTV0-2;B7ZKQ9;Q8WTV0-3 Q8WTV0-4 SCARB1 Scavenger receptor class B member 1 1 25109100.0 9020900.0 7032500.0 9055700.0 True False 12356170.510656144 6721780.896632393 6916930.167995796 1.0 0.5440019535854923 0.5597956229262564 23.558728349093602 -9.783293762194884 6.392082377311396 1.0000000074832336 0.5518987882716531 0.9990691686226615 0.006447738509248512 6.846373331076303e-10 1.3098251280781574e-10 0.00624299601294616 0.002080998655477431 1.6470479309229056e-10 9.783293762194884 -0.4481012192115805 DK(ub)EAIQAYSESLMTSAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKEAIQAYSESLMTSAPK 18 1 Q8WTV0-4;Q8WTV0-2;B7ZKQ9;Q8WTV0-3 Q8WTV0-4 SCARB1 Scavenger receptor class B member 1 1 22284900.0 8478300.0 9165100.0 4641500.0 True False 7050082.102373977 9115725.787170088 5612016.190128763 1.0 1.2929956920786136 0.7960213950187937 22.749208627970084 -6.74693344982011 1.6610312163395664 1.1729158073504597 0.7952503434244587 0.6357371807109696 0.12310499109504726 0.30542493214327643 1.656949345396082 0.05856903029540938 0.1426596669688425 1.790880262938495e-07 6.74693344982011 -0.3776654639260011 DK(ub)EEIVICDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKEEIVICDR 10 1 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 6796700.0 3228200.0 3568500.0 0.0 True False 4232201.461933271 3036093.709904051 0.0 1.0 0.7173792970897851 0.0 22.012976873811606 -7.394610449391981 0.7639306213270635 0.990266901851786 5.482674061786972e-18 0.9874968487759436 0.04706540168776953 0.11271713509821417 0.13885464911621953 0.04071688553726425 0.0728955286752461 4.0307842285595894e-08 7.394610449391981 -0.990266901851786 down DK(ub)EEIVICDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKEEIVICDR 10 1 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 7070600.0 3847800.0 3222800.0 0.0 True False 3725653.6951792343 4509680.846679982 0.0 1.0 1.210440157794384 0.0 21.82906214927558 -6.911892686075443 1.2748337535075775 1.1101552794792193 1.269745128954072e-18 0.9545986726905457 0.11251290311573457 0.12700499626860887 0.4136108472112647 0.07238381271019241 0.14249822606714094 1.2249188386351926e-07 6.911892686075443 -1.1101552794792193 down DK(ub)EEIVICDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKEEIVICDR 10 1 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 7838600.0 3228200.0 3161300.0 1449100.0 True False 4421752.778824751 3021623.312978878 1106852.4251513095 1.0 0.6833541955237916 0.2503198348066618 22.076186935334498 -7.239431851648197 0.38355046900328515 1.0351884615288471 3.9637234494069317e-14 0.9996831757246877 0.005469492491131079 0.09424300865960937 0.026106633927394082 0.009947374354286765 0.046568475950693716 5.76193226197243e-08 7.239431851648197 -1.0351884615288074 down DK(ub)EEIVICDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKEEIVICDR 10 1 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 10856800.0 3847800.0 5777000.0 1232000.0 True False 3199616.186442396 5745878.1543552745 1489605.5038756065 1.0 1.7958023148845323 0.4655575597434003 21.609467424709855 -6.744663641199109 1.6694520105954205 1.4709173857392572 0.4639291006727114 0.6257690074518883 0.33435060953348217 0.30943886017330074 1.6950237491981266 0.15832286383762384 0.3865646810778353 1.8002646708865595e-07 6.744663641199109 -1.0069882850665457 DK(ub)ELYTQNGILHMLDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKELYTQNGILHMLDR 16 1 Q9NP77 Q9NP77 SSU72 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 1 31536600.0 20824000.0 3146100.0 7566500.0 True False 31591530.4383225 2584653.874408506 6070977.958485245 1.0 0.08181477245791041 0.19217106212495388 24.913034493739996 -10.293070269342195 5.442096869903708 1.000122697096446 0.13699291729159846 0.9878847325707444 0.045052766598622285 6.707867126111228e-05 8.713558561539406e-06 0.043628250827766744 0.014540717894735886 5.092484674083884e-11 10.293070269342195 -0.8631297798048476 DK(ub)ENPNQYNYIA ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKENPNQYNYIA 12 1 A0A669KAX4;K4DI93;Q13620-3;Q13620-1;Q13620 A0A669KAX4 CUL4B Cullin-4B 1 2208740.0 500820.0 984580.0 723340.0 True False 416454.02008786285 979275.8721161718 874587.0496537186 1.0 2.351462166002301 2.1000806991110315 18.66779769354973 -10.331973552388021 5.486095760107769 0.9997348128758063 2.225771432556689 0.9694211412733575 0.10262605411273945 0.0003329386152886997 4.054121112493988e-05 0.09938761633486222 0.0331224165387901 4.656144475909986e-11 10.331973552388021 1.2260366196808827 DK(ub)FNECGHVLYADIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKFNECGHVLYADIK 15 1 P52272-2;P52272;A0A087X0X3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 25462800.0 4217000.0 13300000.0 7945800.0 True False 5528527.837486094 11315691.842993964 7123644.837495621 1.0 2.0467821046803993 1.2885247297108395 22.398463933272094 -10.045811780051077 4.4384906672543565 0.9999636051506681 1.6676534168892503 0.5082929215044554 0.3095572772927449 40586187.38319403 22965085.567098647 14154.534206541464 0.10596969114618429 8.99887501477477e-11 10.045811780051077 0.6676898117385822 DK(ub)FNECGHVLYADIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKFNECGHVLYADIK 15 1 P52272-2;P52272;A0A087X0X3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 112049000.0 31318000.0 0.0 80731000.0 True False 47511695.652486704 0.0 64774482.464345716 1.0 0.0 1.3633376282362908 25.501779360452606 -6.710118584627358 1.7948922792059365 0.3852989210828614 1.3601327815158373 0.46564651205682284 0.42138567243456654 0.37482095208228117 2.3539877811530614 0.1868272757355898 0.4745412655391443 1.9493122650402265e-07 6.710118584627358 0.9748338604329758 DK(ub)FNECGHVLYADIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKFNECGHVLYADIK 15 1 P52272-2;P52272;A0A087X0X3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 24054800.0 4217000.0 8620800.0 11217000.0 True False 5776138.860140011 8239904.55082667 8567775.62136654 1.0 1.4265419773213242 1.4833049947069419 22.461673994794985 -11.939139953634681 0.3255382973754201 1.711347444957585e-12 1.494901389926636 0.9995316540845723 0.0046680552243014446 5.098567327663236 0.17406000040010303 3.4832266598467796 0.01848429077804393 1.150429597337069e-12 11.939139953634681 1.4949013899249246 DK(ub)FNECGHVLYADIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKFNECGHVLYADIK 15 1 P52272-2;P52272;A0A087X0X3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 12208900.0 4814500.0 2401500.0 4992900.0 True False 4003470.0685136733 2388562.6428395715 6036892.305438729 1.0 0.5966230799688103 1.5079149343259568 21.932819589420973 -6.786361163597697 1.5106675766256799 0.7734828792785061 1.516681984069561 0.7893768019366829 0.17111393745186676 0.24081724871399374 1.0857022511392862 0.0891736870237851 0.2093596096217022 1.6354558944114825e-07 6.786361163597697 0.7431991047910548 DK(ub)FNECGHVLYADIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKFNECGHVLYADIK 15 1 P52272-2;P52272;A0A087X0X3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 158334000.0 31318000.0 38671000.0 88345000.0 True False 40541768.37007295 36518924.855459005 72267116.49624933 1.0 0.9007728652116832 1.7825348868993918 25.272905682545055 -6.8789449278242065 1.08570511518082 0.9393233893725428 1.843764686146918 0.9728226870631315 0.06501315019361167 0.12856698205716477 0.27798977376594847 0.04617185549497511 0.11135867553142179 1.321463196157489e-07 6.8789449278242065 0.9044412967743751 DK(ub)FQETSDEFEAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKFQETSDEFEAAR 14 1 Q14683;G8JLG1;V9GY57 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 98072600.0 21283500.0 40342800.0 36446300.0 True False 27902874.6097072 34323811.49500276 32675186.493596125 1.0 1.2301173974047022 1.171032983183341 24.73391042323862 -10.059918862837161 4.3230409368898375 0.9999834627350086 1.2005751902836392 0.9388959230290299 0.02412111120493041 3552519.322214569 4133439.630714395 457.2105933481307 0.008257297621654083 8.711263231226711e-11 10.059918862837161 0.20059172754863064 DK(ub)FQETSDEFEAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKFQETSDEFEAAR 14 1 Q14683;G8JLG1;V9GY57 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 99243410.0 35578600.0 38811840.0 24852970.0 True False 34449176.81774105 54309610.11307182 18343231.583881695 1.0 1.5765140165875546 0.5324722759248945 25.03796617355179 -6.7568001923368675 1.6245062051850567 1.336198806883249 0.52924804082973 0.6777808190928922 0.24238472960271834 0.2883227065966955 1.4988713302794012 0.1177669301801782 0.2839148965084867 1.7506519330684695e-07 6.7568001923368675 -0.8069507660535191 DK(ub)FQETSDEFEAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKFQETSDEFEAAR 14 1 Q14683;G8JLG1;V9GY57 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 152254600.0 82755000.0 46125000.0 23374600.0 True False 125545385.20089221 37893633.37373015 18754600.06454888 1.0 0.30183214869343405 0.14938502147680374 26.903633758077497 -13.999999999999936 0.21383778001562784 5.102811972165695 0.0628646814754622 0.9994925112209713 0.008342359723287422 12.839280562124841 0.14654146749982666 22.173708405088558 0.08793407665943906 1.0000000000001472e-14 13.999999999999936 -5.0399472906902325 DK(ub)FQETSDEFEAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKFQETSDEFEAAR 14 1 Q14683;G8JLG1;V9GY57 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 79617900.0 21283500.0 27327800.0 31006600.0 True False 29152585.114960846 26120367.435050234 23683479.680972032 1.0 0.89598803440747 0.8123972398186355 24.79712048476151 -6.973603370841777 0.14874443896858136 1.0988970553671207 0.6072920418082236 0.999998592001615 9.08753164418537e-05 0.0751498204250849 0.004541080143945408 0.00432004633486224 0.010481761071963613 1.0626656173318395e-07 6.973603370841777 -0.4916050135588971 DK(ub)FQETSDEFEAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKFQETSDEFEAAR 14 1 Q14683;G8JLG1;V9GY57 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 79632700.0 35578600.0 30913700.0 13140400.0 True False 29585182.299225412 30747161.76221095 15887996.885655044 1.0 1.0392757242876938 0.5370254854258923 24.818371448986067 -6.888004012043577 1.0341490417931403 1.0282920459465967 0.4954844334360472 0.9795885302262883 0.03258406604482822 0.12077626103241727 0.23144286695807648 0.02406871445321479 0.059586601033689325 1.29418388563119e-07 6.888004012043577 -0.5328076125105495 DK(ub)FQETSDEFEAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKFQETSDEFEAAR 14 1 Q14683;G8JLG1;V9GY57 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 136533300.0 82755000.0 40095600.0 13682700.0 True False 107127978.84492598 37864244.61313492 11192588.996357791 1.0 0.3534486977295225 0.10447867230427 26.674760080169946 -9.5778512590448 0.2836424060917865 1.3943593602029398 3.289996465326586e-19 0.998796490418925 0.013093113622494242 0.9784691974143136 0.11799300306308388 0.4402300941201887 0.09238108418564568 2.643313907471391e-10 9.5778512590448 -1.3943593602029398 DK(ub)GGINLTATCPQSELDAETVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKGGINLTATCPQSELDAETVK 22 1 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 1 7297200.0 2343800.0 3102600.0 1850800.0 True False 3072744.49739149 2639704.173840079 1659296.970127223 1.0 0.8590705071902246 0.540004862602742 21.551096379316846 -6.957549559093699 0.46869296182114323 1.008535329313395 0.3774886459184545 0.9996682432764324 0.003504929721492207 0.08058834812199318 0.024455664428824908 0.004400846288372365 0.02633678734288436 1.1026823951373768e-07 6.957549559093699 -0.6310466833949404 DK(ub)GGINLTATCPQSELDAETVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKGGINLTATCPQSELDAETVK 22 1 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 1 10701800.0 2343800.0 3991000.0 4367000.0 True False 3210366.198813413 3814664.423527885 3335604.541188167 1.0 1.1882334248777686 1.039010609575021 21.614306440839737 -10.095427083984301 5.856720475909889 0.9999994284182536 1.1136220172264013 0.43599200482734146 0.060919959245576284 4.552643852076957e-07 7.023621313517253e-08 0.058985793986319604 0.019661832300808996 8.027363252400186e-11 10.095427083984301 0.11362258880814768 DK(ub)GGINLTATCPQSELDAETVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKGGINLTATCPQSELDAETVK 22 1 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 1 7698500.0 3282800.0 1875200.0 2540500.0 True False 2729793.6526984526 1865097.9254019419 3071706.804055177 1.0 0.6832376958449798 1.1252523797975489 21.38036047011036 -6.714347208981758 1.7796658076555114 0.8061314815736293 1.1243543224594488 0.48572020918200964 0.13339520441688985 0.3664145849724924 2.2647806351897435 0.05958919727079774 0.15059433960280913 1.9304243676741935e-07 6.714347208981758 0.3182228408858194 DK(ub)GGINLTATCPQSELDAETVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKGGINLTATCPQSELDAETVK 22 1 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 1 30610000.0 6181600.0 4720400.0 19708000.0 True False 8002203.05755294 4457705.590434915 16121346.221156623 1.0 0.5570597944559125 2.0146134889616887 22.931965807156374 -6.8251724624597205 1.349267899285679 0.7624143854127575 2.050122898527273 0.895871778359294 0.19687556286700608 0.18685472683154292 0.6669493826385358 0.11461471720846522 0.2638864998535465 1.4956416046773713e-07 6.8251724624597205 1.2877085131145156 up DK(ub)HLEFSSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKHLEFSSLR 10 1 A0A669KB12;Q09472 A0A669KB12 EP300 Histone acetyltransferase p300 1 7232000.0 2373200.0 2461100.0 2397700.0 True False 2297864.0650240015 3443830.0644669523 1769670.4405418404 1.0 1.4987092217010587 0.7701371319035601 21.13186202417662 -6.722488208466515 1.7507099859265831 1.3026055179122182 0.7711375791856783 0.5240873621676374 0.20979701243085638 0.350499733176239 2.1008612589245765 0.09510951299861485 0.23803318046468813 1.8945749532803137e-07 6.722488208466515 -0.53146793872654 DK(ub)HLEFSSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKHLEFSSLR 10 1 A0A669KB12;Q09472 A0A669KB12 EP300 Histone acetyltransferase p300 1 5305260.0 2373200.0 2176900.0 755160.0 True False 1973420.9505860724 2165172.6076191827 913060.464534663 1.0 1.0971671335384188 0.4626790164883471 20.912267299610896 -6.8678399239423875 1.145531040294363 1.05429272277432 0.4270253158020351 0.9624756776370414 0.05405186341826079 0.13893907128521438 0.34211870868922184 0.036666717323203556 0.08649468383304752 1.355689011982166e-07 6.8678399239423875 -0.6272674069722848 down DK(ub)KDEEEDMSLD ddPTM_RPMI8226_Bortezomib_1h_R1 2 DKKDEEEDMSLD 12 2 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 66499230.0 28838400.0 23157400.0 14503430.0 True False 37807421.67146288 19702406.186838187 13002754.190324305 1.0 0.5211253588791961 0.34392068052973873 25.172166130341026 -13.999999999999986 0.13811338952319105 3.2839781874157 0.11955491870028077 0.9996105614950807 0.005468749483228173 11.932553330722833 0.11629543166717057 7.353214001978888 0.20033674622625552 1.0000000000000327e-14 13.999999999999986 -3.1644232687154195 DK(ub)KDEEEDMSLD ddPTM_RPMI8226_Bortezomib_2h_R1 2 DKKDEEEDMSLD 12 2 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 146794700.0 54674800.0 58758700.0 33361200.0 True False 52939178.40147242 82221355.33257252 24622900.905452937 1.0 1.5531286622741705 0.4651167934402263 25.657832469069042 -6.768496260470498 1.5801259593926884 1.3178722147395794 0.45933048526839226 0.7247924150857876 0.2330282434682372 0.26887475287250384 1.3246426699729288 0.11625665143442095 0.2771320401725296 1.7041339928427648e-07 6.768496260470498 -0.8585417294711871 down DK(ub)KDEEEDMSLD ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DKKDEEEDMSLD 12 2 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 68511320.0 28838400.0 18293700.0 21379220.0 True False 39500735.808456644 17485423.844823882 16329888.554857092 1.0 0.44266071218552994 0.4134071991479474 25.235376191863917 -13.81214469803943 0.4214747325195993 9.99983729288117 0.41249182497073317 0.9998634138344964 0.003154221755704523 25.554798218952364 0.2164584641433495 210.72473191069915 0.007074214081292819 1.541186875450113e-14 13.81214469803943 -9.587345467910437 DK(ub)KDEEEDMSLD ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DKKDEEEDMSLD 12 2 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 163632000.0 54674800.0 97444800.0 11512400.0 True False 45464518.70432473 96919845.52112165 13919589.612676585 1.0 2.1317688668702948 0.30616379562272833 25.43823774450332 -6.739037917441376 1.690294826294279 1.6741562260061758 0.3053348459006267 0.6005635967221692 0.4755331186992748 0.31956950477204776 1.7924039769480808 0.2225982485498147 0.5467979710540309 1.8237364683382413e-07 6.739037917441376 -1.368821380105549 DK(ub)KYEEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKKYEEVR 8 2 H0YII8;B4DEG2;K7EQ78;Q93086-2;Q93086-5;Q93086-1;Q93086;Q93086-4 H0YII8 P2RX5 P2X purinoceptor;P2X purinoceptor 5 1 3279860.0 1482000.0 1169700.0 628160.0 True False 1942916.3517084175 995185.3194548889 563164.028936198 1.0 0.5122121282163367 0.28985500505001394 20.889792359298795 -11.020619627236705 0.15144672323830202 2.0065283234839697 7.636845257303726e-12 0.9996463366787041 0.005577632542825656 3.2313752873129493 0.08798186049026879 1.3338493730562053 0.2035193995568072 9.536310271897795e-12 11.020619627236705 -2.0065283234763327 DK(ub)KYEEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKKYEEVR 8 2 H0YII8;B4DEG2;K7EQ78;Q93086-2;Q93086-5;Q93086-1;Q93086;Q93086-4 H0YII8 P2RX5 P2X purinoceptor;P2X purinoceptor 5 1 2038280.0 717470.0 764420.0 556390.0 True False 694694.3075732223 1069656.8923976389 410654.7676577865 1.0 1.5397519178389045 0.591130175072728 19.406018750162055 -6.752358874122216 1.6411076698544769 1.3164740378203124 0.5888982406606009 0.6590806735118524 0.22683850396073302 0.29593894503436446 1.5688552429326563 0.10915779142410725 0.26435337771278855 1.7686468538393805e-07 6.752358874122216 -0.7275757971597114 DK(ub)KYEEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKKYEEVR 8 2 H0YII8;B4DEG2;K7EQ78;Q93086-2;Q93086-5;Q93086-1;Q93086;Q93086-4 H0YII8 P2RX5 P2X purinoceptor;P2X purinoceptor 5 1 2867280.0 1482000.0 721390.0 663890.0 True False 2029935.4495441078 689516.60448228 507092.8552437394 1.0 0.33967415300675435 0.24980737951919832 20.953002420821687 -13.999999999999998 0.2810358000941212 6.4124226578922165 0.2230286188879235 0.9996074722922424 0.00662683078529492 15.454601011200042 0.167949769280572 48.10600282687679 0.035375090214559084 1.0000000000000041e-14 13.999999999999998 -6.189394039004293 DK(ub)KYEEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKKYEEVR 8 2 H0YII8;B4DEG2;K7EQ78;Q93086-2;Q93086-5;Q93086-1;Q93086;Q93086-4 H0YII8 P2RX5 P2X purinoceptor;P2X purinoceptor 5 1 1948570.0 717470.0 610300.0 620800.0 True False 596608.09431021 607012.1927649342 750606.4097451123 1.0 1.0174387484077856 1.2581230742652814 19.18642402559633 -6.9214751792801 0.8137141238853212 0.9949665553805891 1.298283422219176 0.9945809231715312 0.008670696220337799 0.09731151079338686 0.10117440923391409 0.007529648446962499 0.022882895783356862 1.1981875998348323e-07 6.9214751792801 0.30331686683858683 DK(ub)LAQQQAAAAAAAAAAASQQGSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKLAQQQAAAAAAAAAAASQQGSAK 25 1 Q9BZK7;A0A0D9SF63;C9IYU9;A0A1B0GUU2;A0A0D9SF25;C9JLJ1;C9JBN1;C9JCK0 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 1 27386300.0 7226300.0 10040000.0 10120000.0 True False 9473749.279588746 8542071.135613473 9072879.477894684 1.0 0.9016568713737676 0.957686256004501 23.175504061184345 -10.120194183596276 4.21417631364374 1.0000134573641868 0.9296715636785151 0.6774946388903416 0.022873900525394304 31951349.622121986 9043.52165704421 4274.292526377882 0.007830344554299514 7.582384724129323e-11 10.120194183596276 -0.07034189368567167 DK(ub)LAQQQAAAAAAAAAAASQQGSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKLAQQQAAAAAAAAAAASQQGSAK 25 1 Q9BZK7;A0A0D9SF63;C9IYU9;A0A1B0GUU2;A0A0D9SF25;C9JLJ1;C9JBN1;C9JCK0 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 1 45822000.0 12470000.0 11271000.0 22081000.0 True False 12074146.675732898 15771569.077488542 16297323.684199182 1.0 1.3062263943825423 1.3497702257464037 23.525417896321024 -12.473894208551819 0.30030382932842353 6.676237800723625e-08 1.3610783082060898 0.9995392940191757 0.0033406279524234492 6.844226194821713 0.1681957786582267 4.206120624643029 0.015713317958533184 3.3581940780988703e-13 12.473894208551819 1.3610782414437117 DK(ub)LAQQQAAAAAAAAAAASQQGSAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKLAQQQAAAAAAAAAAASQQGSAK 25 1 Q9BZK7;A0A0D9SF63;C9IYU9;A0A1B0GUU2;A0A0D9SF25;C9JLJ1;C9JBN1;C9JCK0 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 1 60228000.0 10312000.0 11000000.0 38916000.0 True False 15644057.908181988 9036964.056607718 31224235.54251125 1.0 0.5776611228140047 1.9959166429690014 23.899111445697535 -6.8269249327705195 1.3417757107129948 0.7738137296879495 2.03168987504203 0.8995460876025797 0.18844718664326046 0.18463916569254335 0.6512231839126332 0.11031116383705586 0.2538887323933257 1.489618534062419e-07 6.8269249327705195 1.2578761453540805 DK(ub)LAQQQAAAAAAAAAAASQQGSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKLAQQQAAAAAAAAAAASQQGSAK 25 1 Q9BZK7;A0A0D9SF63;C9IYU9;A0A1B0GUU2;A0A0D9SF25;C9JLJ1;C9JBN1;C9JCK0 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 1 38300300.0 7226300.0 16058000.0 15016000.0 True False 9898058.393414687 15348504.463295119 11469530.064227499 1.0 1.550658104169873 1.1587656496205694 23.238714122707236 -10.348197000954237 6.183470308769942 0.9999669302494544 1.3547118768951962 0.5220653737768131 0.15998942461544083 7.295197671998102e-05 7.689665030155814e-06 0.15492350184691403 0.05163636475874236 4.485418800420972e-11 10.348197000954237 0.35474494664574185 DK(ub)LAQQQAAAAAAAAAAASQQGSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKLAQQQAAAAAAAAAAASQQGSAK 25 1 Q9BZK7;A0A0D9SF63;C9IYU9;A0A1B0GUU2;A0A0D9SF25;C9JLJ1;C9JBN1;C9JCK0 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 1 41523000.0 12470000.0 16911000.0 12142000.0 True False 10369357.514667258 16819897.086429324 14680836.061735088 1.0 1.6220770730142058 1.4157903265433105 23.3058231717553 -10.043502178209291 4.513807331219849 0.9999762148779237 1.5189336997121172 0.8940410535666199 0.0842162117214376 29146920.206108984 0.41645853473784306 7568.613624329096 0.028829449272856092 9.046859002635316e-11 10.043502178209291 0.5189574848341936 DK(ub)LAQQQAAAAAAAAAAASQQGSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKLAQQQAAAAAAAAAAASQQGSAK 25 1 Q9BZK7;A0A0D9SF63;C9IYU9;A0A1B0GUU2;A0A0D9SF25;C9JLJ1;C9JBN1;C9JCK0 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 1 57028000.0 10312000.0 16913000.0 29803000.0 True False 13349087.279909087 15971776.682278141 24379159.804603714 1.0 1.1964695673475974 1.8262791525301756 23.670237767789985 -6.94995142779373 0.5593769598677291 0.9917359277916723 2.061080207516746 0.9991974635735051 0.009984618909949087 0.08350526087616943 0.036043180207755175 0.010711011772100558 0.052347177607858175 1.1221439497015363e-07 6.94995142779373 1.0693442797250738 DK(ub)LDTVVEFPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKLDTVVEFPIR 12 1 Q13107-2;Q13107;H7C189 Q13107-2 USP4 Ubiquitin carboxyl-terminal hydrolase 4;Ubiquitin carboxyl-terminal hydrolase 1 4640200.0 1856500.0 1023800.0 1759900.0 True False 2542898.2200260693 978565.1307461408 1344247.8662782344 1.0 0.3848227675963015 0.5286282619146485 21.278042288370592 -10.131374071618723 7.845980755883161 1.0000000831375033 0.4567255147562236 0.9500735337374586 0.05870834721477593 8.540351765748404e-08 9.44640485638782e-09 0.05684412165537275 0.018948037587182488 7.389685038399451e-11 10.131374071618723 -0.5432745683812797 DK(ub)LDTVVEFPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKLDTVVEFPIR 12 1 Q13107-2;Q13107;H7C189 Q13107-2 USP4 Ubiquitin carboxyl-terminal hydrolase 4;Ubiquitin carboxyl-terminal hydrolase 1 4289490.0 1819200.0 1696000.0 774290.0 True False 1512745.4042247545 1686863.3113703572 936190.4590875355 1.0 1.1151006022952248 0.6188684867083173 20.528737771043154 -6.845637981403622 1.2559755781672555 1.0612627963772971 0.6006409501941585 0.9337128589293723 0.054599651351094174 0.1623195929496042 0.4949404171774572 0.034051917238569 0.07860845301193334 1.4267964450493165e-07 6.845637981403622 -0.4606218461831386 DK(ub)LNNLVLFDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKLNNLVLFDK 11 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 17917200.0 6150700.0 5814600.0 5951900.0 True False 8063627.263463532 4947084.345133281 5336054.482656258 1.0 0.6135060790258283 0.6617436927961732 22.94299752195404 -10.47642149203053 5.172249161217971 1.0007097082707619 0.6376248859109942 0.9868845691880329 0.01969292335782241 0.00016146920200112028 1.6345255031859807e-05 0.01910355995377075 0.006355863683578796 3.3387085397284765e-11 10.47642149203053 -0.3630848223597677 DK(ub)LNNLVLFDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKLNNLVLFDK 11 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 38598800.0 9885500.0 10166000.0 18547300.0 True False 9571690.213549118 14225336.814989645 13689205.722926848 1.0 1.4861885934056975 1.4301764283542333 23.19034227432755 -10.494666547105458 6.063210714907146 0.9996045466125608 1.4581825108799655 0.988915700118461 0.022866870627440184 0.00012233983214497137 1.0196310210318762e-05 0.022159182519327535 0.007380250759996247 3.201352176229608e-11 10.494666547105458 0.4585779642674047 DK(ub)LNNLVLFDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKLNNLVLFDK 11 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 39429900.0 7276900.0 6015900.0 26137100.0 True False 11039589.312650254 4942315.642558762 20971090.728702106 1.0 0.4476901723957582 1.8996259856035906 23.39618316715882 -6.803646548195287 1.4412480301859862 0.6966645291062875 1.9214563517468752 0.842536910315317 0.23744551103313868 0.21559681858304114 0.8837620595563012 0.12959345902497998 0.3007057097218494 1.5716413687988944e-07 6.803646548195287 1.2247918226405878 DK(ub)LNNLVLFDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKLNNLVLFDK 11 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 16944700.0 6150700.0 5000600.0 5793400.0 True False 8424780.006417632 4779656.95722715 4425118.238818296 1.0 0.5673331474039933 0.5252503015446615 23.006207583476932 -13.999999999999998 0.32950839935627374 5.695942815569682 0.5177544960709467 0.9997138202505169 0.0036298272263859356 18.78205031814937 0.18353517670676744 61.1085530497951 0.013510489094217171 1.0000000000000041e-14 13.999999999999998 -5.178188319498735 DK(ub)LNNLVLFDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKLNNLVLFDK 11 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 30320900.0 9885500.0 14953000.0 5482400.0 True False 8220231.25190402 14872445.22106187 6628744.492246447 1.0 1.809249005934842 0.8063939187490688 22.970747549761825 -6.69196266726276 1.85932955912634 1.5064137570287448 0.809768919543742 0.37964257618614494 0.34212083708641067 0.41248464711589067 2.7662445336675754 0.14711231240738712 0.3821614996291509 2.0325317235209584e-07 6.69196266726276 -0.6966448374850028 DK(ub)LNNLVLFDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKLNNLVLFDK 11 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 19289600.0 7276900.0 8249000.0 3763700.0 True False 9420090.499143751 7789935.898546227 3078745.2188231726 1.0 0.8269491571502738 0.32682756276099667 23.16730948925127 -6.952287071770411 0.5331436602651509 1.007713877003845 0.12323677903149267 0.9993687627431364 0.007171249491396221 0.08258014568759599 0.032260542530040945 0.007964008611537617 0.04137482625477358 1.1161252370976808e-07 6.952287071770411 -0.8844770979723523 down DK(ub)LPNYEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKLPNYEEK 9 1 Q9BV57;Q9BV57-2 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 3140280.0 641780.0 1234500.0 1264000.0 True False 841379.7950063604 1050317.4120433107 1133213.4051441578 1.0 1.2483273526141316 1.346851222087632 19.682397647910612 -13.366975630592599 0.1340553243883057 1.6788505688851778e-17 1.4820787844666627 0.9996389139063379 0.0027731328583975486 9.57273459051075 0.10866893681994853 2.603992735728939 0.1161838853898891 4.295605298615189e-14 13.366975630592599 1.4820787844666627 DK(ub)LPNYEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKLPNYEEK 9 1 Q9BV57;Q9BV57-2 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 2790560.0 641780.0 913680.0 1235100.0 True False 879063.4094523719 873310.5964642839 943394.817682965 1.0 0.9934557474168196 1.073181760881925 19.745607709433504 -6.8869937676464215 1.0399803362155917 0.9954024465286613 1.0796488220010085 0.9789041067340432 0.005249065769092052 0.12161713743463555 0.2363561357415276 0.0038600499613457434 0.00952488447650298 1.2971978863203624e-07 6.8869937676464215 0.08424637547234726 DK(ub)LQAHGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKLQAHGIR 9 1 P11172;P11172-3;E9PFD2 P11172 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 1 2000040.0 402200.0 677480.0 920360.0 True False 389432.38115314895 948001.2970115282 679290.105791838 1.0 2.4343155394638725 1.7443082256806453 18.57101332302198 -10.66674194328925 7.0570452508298915 0.9951545680359943 2.0893118825717467 0.7686814053745584 0.28169430625956526 0.02143758686060171 0.0010123557408612132 0.27227120128387455 0.09091644640539555 2.1540612924426045e-11 10.66674194328925 1.0941573145357524 DK(ub)LQAHGIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKLQAHGIR 9 1 P11172;P11172-3;E9PFD2 P11172 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 1 2341720.0 402200.0 1054100.0 885420.0 True False 334447.120481088 1048421.3540775313 1070557.228280471 1.0 3.134789597139965 3.200976066830893 18.351418598456256 -10.492077921160803 0.6702684356206554 4.292430450078548e-19 3.190499588447687 0.9999024017112548 0.010099557135029908 1.898979210820267 0.33527096765648945 3.3264351449542473 0.010604548557083553 3.220490918630723e-11 10.492077921160803 3.190499588447687 DK(ub)LQAHGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKLQAHGIR 9 1 P11172;P11172-3;E9PFD2 P11172 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 1 14189300.0 864030.0 904270.0 12421000.0 True False 1118503.8675775656 853946.5795827843 10160505.450222561 1.0 0.7634721741572924 9.08401458836972 20.09313881429995 -6.900356908477608 0.9590040855754117 0.6574420499761587 9.963768343972541 0.9867431798349972 0.4453314055488221 0.1111431958718673 0.17593984552671438 0.34804265265133527 0.9071844930668401 1.2578912366143332e-07 6.900356908477608 9.306326293996383 up DK(ub)LSGEYEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKLSGEYEK 9 1 P34932;A0A087WYC1 P34932 HSPA4 Heat shock 70 kDa protein 4 1 3183410.0 864000.0 955610.0 1363800.0 True False 836572.7929296889 1337190.0564403164 1006579.866876991 1.0 1.598414468820411 1.203218506965706 19.67413155376746 -10.185958725029112 4.961899577911806 0.9999633769698469 1.4008164878937313 0.5783310549068161 0.16133807582773554 6.537044900578494e-05 1.0724428547288201e-05 0.1562291651258911 0.05207164006549774 6.51690327201234e-11 10.185958725029112 0.4008531109238843 DK(ub)LSGEYEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKLSGEYEK 9 1 P34932;A0A087WYC1 P34932 HSPA4 Heat shock 70 kDa protein 4 1 2610830.0 864000.0 1364700.0 382130.0 True False 718454.2816898563 1357348.0902282584 462031.6162305083 1.0 1.8892616062300829 0.6430911861834502 19.454536829201736 -6.7150836173949875 1.7769452816640114 1.5438156599096924 0.6455336757621777 0.4893486072487939 0.37444420775504156 0.3649073790375947 2.248982636170628 0.16749523677757133 0.4229362473871112 1.9271538306564932e-07 6.7150836173949875 -0.8982819841475147 DK(ub)MCSMVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKMCSMVK 8 1 P61247;D6RG13;D6RAT0;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7 P61247 RPS3A 40S ribosomal protein S3a 1 7216300.0 2076900.0 2946200.0 2193200.0 True False 2722836.012728209 2506638.4441976515 1966268.7026599431 1.0 0.9205983880336835 0.7221399648999773 21.376678665643468 -6.955466546219752 0.49520907529778846 1.0041449810194312 0.6301031085883231 0.9995633711196499 0.002441763658427716 0.08136210400189163 0.02743147803037221 0.002890034991296653 0.016369008100811478 1.1079839102824666e-07 6.955466546219752 -0.3740418724311081 DK(ub)MCSMVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKMCSMVK 8 1 P61247;D6RG13;D6RAT0;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7 P61247 RPS3A 40S ribosomal protein S3a 1 3182330.0 1330500.0 989020.0 862810.0 True False 1288264.0057788787 1383940.8436711635 636814.1772548304 1.0 1.0742680362589492 0.49431962268464946 20.29699684662621 -6.874741849365398 1.1087748592495352 1.0434802029318895 0.4571588400117351 0.9691875729717964 0.045230934568059614 0.13238621134493753 0.30134110047059554 0.03156031918341184 0.07539579192631735 1.3343143313409358e-07 6.874741849365398 -0.5863213629201544 down DK(ub)MCSMVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKMCSMVK 8 1 P61247;D6RG13;D6RAT0;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7 P61247 RPS3A 40S ribosomal protein S3a 1 16107700.0 4319300.0 3234600.0 8553800.0 True False 6552693.883127465 2657360.35795485 6863137.680736277 1.0 0.4055370822063409 1.047376514628308 22.643656705415193 -11.97862455752394 18.412888459512374 0.9164278557663204 0.7538111185756134 0.0 0.2989338898516479 0.0 0.0 0.0 0.08694383107955471 1.0504501380438752e-12 11.97862455752394 -0.1626167371907069 DK(ub)MCSMVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKMCSMVK 8 1 P61247;D6RG13;D6RAT0;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7 P61247 RPS3A 40S ribosomal protein S3a 1 7311000.0 2076900.0 1885300.0 3348800.0 True False 2844786.056112112 1802001.2121466128 2557882.410700926 1.0 0.6334399763648154 0.8991475493228166 21.43988872716636 -9.892223241231052 6.280069759821474 1.0000000258080375 0.7662937628437811 0.5077541834859554 0.10847466242353097 3.9157543900275144e-08 6.9779477322722146e-09 0.10503015121837983 0.03501004675429888 1.28167159317607e-10 9.892223241231052 -0.23370626296425634 DK(ub)MCSMVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKMCSMVK 8 1 P61247;D6RG13;D6RAT0;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7 P61247 RPS3A 40S ribosomal protein S3a 1 12702800.0 4319300.0 3453700.0 4929800.0 True False 5591418.996131816 3261498.5589536997 4032626.9840195808 1.0 0.5833042669866143 0.7212170983446923 22.414783027507642 -10.349697584638996 4.990699102767574 1.0001976014450922 0.6522606826655765 0.8944802445420021 0.056302677635232924 0.00012385875368568251 1.6139273247480756e-05 0.054545525816964646 0.01817161106897369 4.4699474282940345e-11 10.349697584638996 -0.3479369187795157 DK(ub)NEQAFEEVFQNANFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKNEQAFEEVFQNANFR 17 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 20017900.0 3959000.0 4287900.0 11771000.0 True False 3833323.712047038 6000080.831103104 8687821.977569338 1.0 1.5652424062821957 2.2663940303987378 21.87016440363409 -6.968222103143122 0.2976063619188137 0.8748853641647791 2.978646532288063 0.9999650025759891 0.003064379653993008 0.07688393333028865 0.011084175051774604 0.011772684442022356 0.063044520742994 1.075914837808682e-07 6.968222103143122 2.1037611681232837 DK(ub)NEQAFEEVFQNANFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKNEQAFEEVFQNANFR 17 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 29530100.0 4721900.0 6473200.0 18335000.0 True False 7163467.517129987 5318006.88465756 14711079.21348402 1.0 0.7423788649757426 2.0536254514040087 22.772226670614135 -6.855694288247989 1.2072618885439466 0.8615285223918218 2.1121061645578503 0.9481943312723651 0.12910895970279315 0.15130189833293411 0.4214998266831362 0.08354347269214514 0.19416963327035142 1.3941378293291567e-07 6.855694288247989 1.2505776421660286 up DK(ub)NEQAFEEVFQNANFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKNEQAFEEVFQNANFR 17 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 12563900.0 1803300.0 3716500.0 7044100.0 True False 2470028.742350127 3552292.7411779943 5380428.657793345 1.0 1.438158463612913 2.1782858496918123 21.236096399071265 -6.963208446331313 0.3875723674005526 0.9532963605389188 2.6896383516140503 0.9998713183437811 0.005516146556101468 0.07857429197090578 0.017037054513527924 0.009570225857122288 0.06232338709157544 1.0884075699557006e-07 6.963208446331313 1.7363419910751317 DK(ub)NEQAFEEVFQNANFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKNEQAFEEVFQNANFR 17 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 17375300.0 3959000.0 6335900.0 7080400.0 True False 3292083.913437666 6301767.249122318 8560878.90392926 1.0 1.9142182929784055 2.6004437095255577 21.650569679068365 -7.360549888600265 0.14120679148291593 7.091695439851663e-13 4.267422015224197 0.9999937645824184 0.0016370381937799955 0.11951125164252444 0.009678904857713737 0.09845034193982886 0.17836026187111798 4.359634808011029e-08 7.360549888600265 4.267422015223488 DK(ub)NEQAFEEVFQNANFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKNEQAFEEVFQNANFR 17 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 34705200.0 4721900.0 7678300.0 22305000.0 True False 6112592.632564258 7250995.855231842 18245718.86862688 1.0 1.1862390136392942 2.984939446385572 22.543352992706584 -6.926769877044032 0.7728448193326108 0.9691236319573876 3.325560664871935 0.9958644755020513 0.05755876383689549 0.09434996602192085 0.08615318073649218 0.05146431553987007 0.16573574387135726 1.1836685891603238e-07 6.926769877044032 2.3564370329145476 up DK(ub)NSIYSGLEAFGDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKNSIYSGLEAFGDVK 16 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 31428700.0 23923400.0 3711300.0 3794000.0 True False 23163964.762007087 5193241.444173825 2800237.5824397323 1.0 0.2241948430474061 0.120887663714314 24.46537887146542 -13.999999999999998 0.28415918828366704 7.4700064446792425 0.0910418612716243 0.9996144151704752 0.007704132743961599 15.62777025952208 0.16893171242549077 58.90513471395585 0.0400748110148417 1.0000000000000041e-14 13.999999999999998 -7.378964583407618 DK(ub)NSIYSGLEAFGDVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKNSIYSGLEAFGDVK 16 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 134873800.0 6882700.0 21392100.0 106599000.0 True False 10441559.092769993 17574512.617759816 85529660.9259985 1.0 1.6831310785693743 8.191272985776756 23.315833809785158 -6.926999147238392 0.7710277485933111 0.8892427436825715 9.430678748720732 0.9959148728517558 0.20714879488284524 0.09422613098009411 0.0855355009711897 0.185457002003358 0.5988846131162445 1.1830438786959884e-07 6.926999147238392 8.541436005038161 up DK(ub)NSIYSGLEAFGDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKNSIYSGLEAFGDVK 16 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 60336300.0 23923400.0 19581700.0 16831200.0 True False 19893367.086318415 19476209.49543689 20350526.101323977 1.0 0.9790303175389337 1.0229804744979532 24.245784146899695 -6.777010382719576 1.5479837371486223 0.9880800326817876 1.0232936724884016 0.7564976124162197 0.008857023691216864 0.2552550269184619 1.2079891411723815 0.004507905984811595 0.010661602538590388 1.6710506638656544e-07 6.777010382719576 0.03521363980661407 DK(ub)NSIYSGLEAFGDVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKNSIYSGLEAFGDVK 16 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 139644000.0 6882700.0 25560300.0 107201000.0 True False 8909790.828300066 24137846.83569054 87691517.97514756 1.0 2.709137318804587 9.842152264294915 23.086960131877607 -6.943900229573286 0.622220669283339 0.9220372689684023 12.008589659080153 0.9986314320522786 0.14166864405371485 0.08603149695679811 0.04683912504954404 0.14238343800221362 0.6041788528129907 1.1378886628448473e-07 6.943900229573286 11.08655239011175 DK(ub)PGSSLQSFMPEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKPGSSLQSFMPEGK 15 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 35382800.0 6005000.0 20326100.0 9051700.0 True False 9110024.024304966 16698748.64645583 7262627.527498958 1.0 1.8330081898691628 0.7972127744254822 23.11902342792888 -6.692648272582377 1.8572302761579125 1.5209456071894327 0.800694483337792 0.38277660257281354 0.352116868800239 0.41098446872334754 2.7505677044731027 0.15156446178216892 0.3933393296152581 2.0293255690508958e-07 6.692648272582377 -0.7202511238516407 DK(ub)QELPNGDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKQELPNGDPK 11 1 Q969F2-2;Q969F2 Q969F2-2 NKD2 Protein naked cuticle homolog 2 1 1490050.0 737180.0 752870.0 0.0 True False 966450.1188612748 640544.7306642747 0.0 1.0 0.6627809528535213 0.0 19.882335747350766 -7.506197825872178 0.7128838772628034 0.9932829549186479 5.2153686075857965e-17 0.9870810513865276 0.047214717440993065 0.11922310139648926 0.14261709628698024 0.04175073465695656 0.07566153549120846 3.117469219399482e-08 7.506197825872178 -0.9932829549186479 down DK(ub)QELPNGDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKQELPNGDPK 11 1 Q969F2-2;Q969F2 Q969F2-2 NKD2 Protein naked cuticle homolog 2 1 2089990.0 737180.0 921750.0 431060.0 True False 1009735.367540434 881024.0371803631 329252.5059593707 1.0 0.8725296404407497 0.32607801662071234 19.945545808873657 -6.943286396915506 0.628246246258451 1.0059613250128918 0.16328398711986458 0.9985634428749016 0.011079278254020504 0.08629884319710568 0.048018820921914195 0.011075203127338111 0.04639431651927153 1.1394980939926869e-07 6.943286396915506 -0.8426773378930272 down DK(ub)QLDAAIAWQGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKQLDAAIAWQGK 13 1 A0A3B3IUD2;Q9BUK6-7;Q9BUK6-3;Q9BUK6-2;Q9BUK6 A0A3B3IUD2 MSTO1 Protein misato homolog 1 1 3252700.0 1257900.0 1994800.0 0.0 True False 1628376.346915983 1883787.6264298712 0.0 1.0 1.1568502760419097 0.0 20.635002740108515 -6.933178000809391 1.234310398157711 1.08431323076017 1.789388907221642e-21 0.9654770959879568 0.09520406584425674 0.11533739514873236 0.35069906477057694 0.06374610318156844 0.12294136736151111 1.1663314841167005e-07 6.933178000809391 -1.08431323076017 down DK(ub)STYIESSTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKSTYIESSTK 11 1 O96005-3;O96005-4;O96005;K7EJ16 O96005-3 CLPTM1 Cleft lip and palate transmembrane protein 1 1 8531100.0 1772000.0 1708400.0 5050700.0 True False 2323109.1600724123 1453513.3792910434 4528102.013735446 1.0 0.625675884832608 1.9491559378958772 21.14762551554798 -6.831159188682932 1.3227529929547688 0.8001435952277403 1.9856131196223457 0.9081691842206512 0.16880235394577126 0.17938403547075218 0.6134308062655841 0.10018656484043177 0.23054880424181012 1.475165718826682e-07 6.831159188682932 1.1854695243946054 DK(ub)STYIESSTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKSTYIESSTK 11 1 O96005-3;O96005-4;O96005;K7EJ16 O96005-3 CLPTM1 Cleft lip and palate transmembrane protein 1 1 12451600.0 1405800.0 1840000.0 9205800.0 True False 1361173.6484960157 2574721.5954732406 6794524.811919787 1.0 1.8915452839673286 4.991666433909571 20.37641969630092 -6.948093694547034 0.5793939441656658 0.9628582741375231 6.073530894446092 0.9990430712255901 0.052919804661739414 0.08426036768368474 0.03920081623218984 0.05548254618597402 0.25892827260469725 1.1269543012013682e-07 6.948093694547034 5.110672620308569 DK(ub)STYIESSTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKSTYIESSTK 11 1 O96005-3;O96005-4;O96005;K7EJ16 O96005-3 CLPTM1 Cleft lip and palate transmembrane protein 1 1 39900100.0 5033100.0 10975000.0 23892000.0 True False 7635580.66889747 9016425.501933618 19169735.72776441 1.0 1.1808434607548364 2.510579949191002 22.86430644426173 -6.931700737736309 0.7327014279940743 0.9810006321421165 2.7957762063428544 0.9968620245464439 0.0377294248823048 0.09176425012488537 0.07342508532874305 0.03472783575573715 0.11921284314740431 1.1703055436683867e-07 6.931700737736309 1.8147755742007379 up DK(ub)STYIESSTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKSTYIESSTK 11 1 O96005-3;O96005-4;O96005;K7EJ16 O96005-3 CLPTM1 Cleft lip and palate transmembrane protein 1 1 11057640.0 1772000.0 951740.0 8333900.0 True False 2427156.286499432 909688.979816696 6365604.462058178 1.0 0.3747962110543346 2.62265948734557 21.21083557707087 -6.832485349833941 1.3166014836860798 0.6664412183927337 2.6863438402888025 0.9107696810983008 0.28297915230659254 0.17777620479104886 0.6017789902517506 0.16870070397004672 0.38825957496285446 1.4706680249858138e-07 6.832485349833941 2.019902621896069 up DK(ub)STYIESSTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKSTYIESSTK 11 1 O96005-3;O96005-4;O96005;K7EJ16 O96005-3 CLPTM1 Cleft lip and palate transmembrane protein 1 1 11663200.0 1405800.0 2679500.0 7577900.0 True False 1168984.9874995379 2665065.0016608937 9162403.853749158 1.0 2.279811143992084 7.837914046567497 20.156824971735197 -6.942989621724732 0.631137165412233 0.9393662514156061 9.478495291073457 0.9985298571678435 0.1138048715701197 0.08642881782529949 0.048594604935908566 0.11347288462106626 0.4724365049480302 1.140277036278478e-07 6.942989621724732 8.539129039657851 DK(ub)STYIESSTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKSTYIESSTK 11 1 O96005-3;O96005-4;O96005;K7EJ16 O96005-3 CLPTM1 Cleft lip and palate transmembrane protein 1 1 37235100.0 5033100.0 10756000.0 21446000.0 True False 6515447.167233358 10157419.144716121 17543048.05454256 1.0 1.558974984218811 2.692531702623234 22.635432766354178 -6.959772719598044 0.43862472006457304 0.9588827360313588 3.336718952034297 0.999761678163279 0.010869978052977184 0.07978240191940598 0.021432015070180128 0.014920140400217748 0.09394710700147303 1.0970521689571139e-07 6.959772719598044 2.3778362160029385 DK(ub)TGSSAQK(ub)SLSEYNNFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKTGSSAQKSLSEYNNFK 18 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 2 8911500.0 1928300.0 3194900.0 3788300.0 True False 2528019.9736837638 2718233.3736226587 3396323.055939572 1.0 1.0752420478947882 1.3434716067494277 21.269576431502433 -6.947523207103764 0.5854122575990962 0.9968545415291801 1.4352499066961586 0.998992237556813 0.004679732838590503 0.08449597394093376 0.04019917576305237 0.004874895256889849 0.022440688646504826 1.1284356364562591e-07 6.947523207103764 0.4383953651669785 DK(ub)TGSSAQK(ub)SLSEYNNFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKTGSSAQKSLSEYNNFK 18 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 2 15680000.0 2728000.0 2761000.0 10191000.0 True False 2641401.1332317013 3863481.6984247887 7521671.376553317 1.0 1.4626637544059415 2.8476066288919557 21.332871980628163 -6.951500568700489 0.5421253654614816 0.9798902468188232 3.394569547707565 0.9993138060123459 0.020562849468852718 0.08288884099978223 0.03351231991506592 0.022551353849911585 0.11473237034255714 1.1181483603889281e-07 6.951500568700489 2.4146793008887415 up DK(ub)TGSSAQK(ub)SLSEYNNFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKTGSSAQKSLSEYNNFK 18 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 2 34203300.0 5273300.0 5284000.0 23646000.0 True False 7999981.629869661 4341028.9159195665 18972357.73559002 1.0 0.5426298605126038 2.3715501626594513 22.931565256508378 -6.840496579323805 1.280253540062035 0.7567180783207896 2.4322342779772868 0.9252771742128846 0.21243037702605697 0.16822170672037703 0.535407578483592 0.13010485573876898 0.2997492953453569 1.4437879760947007e-07 6.840496579323805 1.6755161996564971 up DK(ub)TGSSAQK(ub)SLSEYNNFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKTGSSAQKSLSEYNNFK 18 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 2 10197400.0 1928300.0 2061500.0 6207600.0 True False 2641244.62034811 1970416.1135311306 4741492.729535072 1.0 0.7460180319350482 1.7951736438975328 21.332786493025324 -6.842763070197978 1.269596963490427 0.864903044235784 1.8315907428836904 0.929086046518967 0.11900996497290342 0.1655973547973541 0.5173157167319896 0.07346952079066292 0.1693967273094168 1.4362727797511838e-07 6.842763070197978 0.9666876986479064 DK(ub)TGSSAQK(ub)SLSEYNNFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKTGSSAQKSLSEYNNFK 18 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 2 10349400.0 2728000.0 4014800.0 3606600.0 True False 2268452.8708911194 3993171.4755245945 4360723.384965724 1.0 1.7603061217471765 1.9223336931186477 21.11327725606244 -11.040451697339083 0.29029080375926314 1.4616889276037568e-14 1.9750777673214102 0.9992443717648157 0.01105266289201763 2.972066796568413 0.15029546986635656 2.0355619217065803 0.06082961400709572 9.110627759322888e-12 11.040451697339083 1.9750777673213955 DK(ub)TLIEEQWEDFCSMLGTHPHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKTLIEEQWEDFCSMLGTHPHLR 23 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 76242100.0 14125200.0 25479900.0 36637000.0 True False 21428961.090443354 20932812.769632652 29395680.891432438 1.0 0.9768468327178041 1.371773496968175 24.35305857180894 -6.892982785462478 1.0045417660916316 0.9802724970424515 1.4077981046630084 0.9827407352041304 0.023773531760634074 0.11675752854542472 0.20796429700456873 0.017957534461919444 0.045278224401717346 1.2794320171987462e-07 6.892982785462478 0.4275256076205569 DK(ub)TLIEEQWEDFCSMLGTHPHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKTLIEEQWEDFCSMLGTHPHLR 23 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 45236000.0 14125200.0 15129800.0 15981000.0 True False 18285349.849318422 14287813.329836916 13072621.978907231 1.0 0.7813803644762907 0.7149232629746216 24.12418489390139 -13.999999999483316 0.1668189371369683 2.093627045402294 0.6542702159708904 0.9995201097441251 0.0026678200308572955 12.06217439351907 0.12926955509340196 4.267806791521559 0.055792158271354385 1.000000001189708e-14 13.999999999483316 -1.4393568294314036 DK(ub)VAGHSLGYGFVNYVTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKVAGHSLGYGFVNYVTAK 19 1 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 1 20912800.0 2994500.0 5265300.0 12653000.0 True False 3876439.28041968 4972281.4264293155 10350283.830743598 1.0 1.2826929733028076 2.6700492596450607 21.88630063640672 -6.940221910139179 0.657494639710873 0.9844847920707718 3.046631598233881 0.9981928368968678 0.031025195669516194 0.08766551707886999 0.054149487915312364 0.030251738662210644 0.11929068889337421 1.1475671027687124e-07 6.940221910139179 2.0621468061631094 up DK(ub)VASGGGGVGDGVQEPTTGNWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKVASGGGGVGDGVQEPTTGNWR 23 1 O00429-9;O00429-4 O00429-9 DNM1L Dynamin-1-like protein 1 5936900.0 1511600.0 2115400.0 2309900.0 True False 1463615.0854080087 2960090.2516652658 1704867.8944853814 1.0 2.0224513133110325 1.1648335081283474 20.481104759976592 -10.25128648759233 4.431844244889513 0.9997146741973583 1.5936424107272054 0.3898171793772629 0.35012100286274656 247365040.5537947 354.3330764968657 720248.259202284 0.11985573194887084 5.6067799601347144e-11 10.25128648759233 0.5939277365298471 DK(ub)VASGGGGVGDGVQEPTTGNWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKVASGGGGVGDGVQEPTTGNWR 23 1 O00429-9;O00429-4 O00429-9 DNM1L Dynamin-1-like protein 1 18074800.0 1887400.0 4535400.0 11652000.0 True False 2863323.787422677 3726022.434758059 9348977.09274698 1.0 1.3012927322871546 3.2650785544453367 21.449259390236517 -6.934110052727718 0.7122559394701629 0.9742031721956715 3.7139378526148317 0.9972860310276249 0.05232048920156159 0.09055931260121954 0.06763443160090969 0.04889054837717394 0.1738485813940196 1.1638310705310177e-07 6.934110052727718 2.73973468041916 up DK(ub)VASGGGGVGDGVQEPTTGNWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKVASGGGGVGDGVQEPTTGNWR 23 1 O00429-9;O00429-4 O00429-9 DNM1L Dynamin-1-like protein 1 10838200.0 1887400.0 4415400.0 4535400.0 True False 2443276.5062160958 4169679.10855146 3710003.7371338373 1.0 1.706593215275927 1.5184543082598223 21.220385712328966 -10.135747468110386 5.112232411832256 0.999976619012125 1.6125237617687416 0.9339182579957663 0.07680738716208174 2.046899691138153e-05 3.4603384250766862e-06 0.07437126519326485 0.024789477611604122 7.315643470617544e-11 10.135747468110386 0.6125471427566166 DK(ub)VNCSFYFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKVNCSFYFK 10 1 P0DN76;Q01081;Q01081-2;Q8WU68-3;Q8WU68;A0A1B0GW87;M0QYK5;M0R2N4;Q01081-3;Q8WU68-2 P0DN76 U2AF1;U2AF1L4 Splicing factor U2AF 35 kDa subunit;Splicing factor U2AF 26 kDa subunit 1 9620900.0 3084900.0 4600300.0 1935700.0 True False 4044333.7742140978 3913953.171828956 1735412.3325455298 1.0 0.9677621557309578 0.4290972084475788 21.947470635440638 -6.919162697167387 0.830916024779669 1.012247935167722 0.34388466391855355 0.9939450526191177 0.020376142213996362 0.098667100601658 0.10818673090950631 0.017478697420295435 0.05194495633204591 1.2045845894492894e-07 6.919162697167387 -0.6683632712491685 down DK(ub)VNCSFYFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKVNCSFYFK 10 1 P0DN76;Q01081;Q01081-2;Q8WU68-3;Q8WU68;A0A1B0GW87;M0QYK5;M0R2N4;Q01081-3;Q8WU68-2 P0DN76 U2AF1;U2AF1L4 Splicing factor U2AF 35 kDa subunit;Splicing factor U2AF 26 kDa subunit 1 37925800.0 7552700.0 9449100.0 20924000.0 True False 11457998.076331068 7762834.278844723 16788362.228685003 1.0 0.6775035418168299 1.4652090283873356 23.449851664882043 -6.795539516048355 1.4740173383716813 0.8210435863621807 1.4749257831596478 0.818797203474668 0.13763652457699438 0.22719576283362225 0.9749457235080639 0.07347380110404149 0.1713608750199377 1.6012549450272753e-07 6.795539516048355 0.6538821967974672 DK(ub)VNCSFYFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKVNCSFYFK 10 1 P0DN76;Q01081;Q01081-2;Q8WU68-3;Q8WU68;A0A1B0GW87;M0QYK5;M0R2N4;Q01081-3;Q8WU68-2 P0DN76 U2AF1;U2AF1L4 Splicing factor U2AF 35 kDa subunit;Splicing factor U2AF 26 kDa subunit 1 7408200.0 3456700.0 1501400.0 2450100.0 True False 2874399.2077746866 1493311.660195432 2962404.582017553 1.0 0.5195213163698057 1.0306169630178124 21.454829012149666 -10.13535703597243 13.638270061252413 0.999998774864995 0.775069139693809 0.20524242498255663 0.20865392400877025 0.0 0.0 0.20202829320115703 0.06734276440038565 7.322223214821479e-11 10.13535703597243 -0.22492963517118603 DK(ub)VNCSFYFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKVNCSFYFK 10 1 P0DN76;Q01081;Q01081-2;Q8WU68-3;Q8WU68;A0A1B0GW87;M0QYK5;M0R2N4;Q01081-3;Q8WU68-2 P0DN76 U2AF1;U2AF1L4 Splicing factor U2AF 35 kDa subunit;Splicing factor U2AF 26 kDa subunit 1 46515700.0 7552700.0 11323000.0 27640000.0 True False 9777119.03597452 10692865.096283058 22609803.61034956 1.0 1.0936621572202494 2.3125220759978156 23.220977986974493 -6.922257596533606 0.807806805324112 0.9752320653543266 2.519656282132628 0.9947854205694733 0.04317388105226089 0.0968614786032691 0.09886409698501662 0.03765056733435931 0.11533474650701765 1.196030909568431e-07 6.922257596533606 1.5444242167783013 up DK(ub)WLAPDGLIFPDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKWLAPDGLIFPDR 14 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;E9PNR9;H0YDE4 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 9052460.0 868560.0 1863700.0 6320200.0 True False 1138690.5711470048 1585643.2246456996 5666246.331639324 1.0 1.3925145819451887 4.976107184177089 20.11894433031193 -6.927724961397969 0.7652365409905931 0.9406578845980111 5.670915846036598 0.9960718811037264 0.11212688595451872 0.09383657104376432 0.08359465894581393 0.10080301584796783 0.3284034762305259 1.1810683692013173e-07 6.927724961397969 4.730257961438587 up DK(ub)WLAPDGLIFPDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKWLAPDGLIFPDR 14 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;E9PNR9;H0YDE4 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 17131900.0 2247700.0 2673200.0 12211000.0 True False 2176347.993828777 3740622.700553836 9012572.777852274 1.0 1.7187612969803978 4.1411450757912815 21.053477828500004 -6.948809581088394 0.5717625977951237 0.9700596918974363 5.007978419062664 0.9991045287735053 0.04021141218151899 0.08396729392401364 0.03796791594949462 0.04251638260682747 0.20192032374015448 1.1250981715959572e-07 6.948809581088394 4.037918727165228 DK(ub)WLAPDGLIFPDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKWLAPDGLIFPDR 14 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;E9PNR9;H0YDE4 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 33274400.0 3065500.0 9488900.0 20720000.0 True False 4650587.618069423 7795531.657885916 16624682.918101367 1.0 1.6762465946447511 3.5747488884001917 22.148981586644652 -6.952931950165702 0.5256702116876092 0.9690960626624245 4.367448219513521 0.9994117460829048 0.026434393087944822 0.08232932752135516 0.03125184811972056 0.029683532129707268 0.1569126801367826 1.1144691466770224e-07 6.952931950165702 3.398352156851096 DK(ub)WLAPDGLIFPDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKWLAPDGLIFPDR 14 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;E9PNR9;H0YDE4 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 13627060.0 868560.0 1914500.0 10844000.0 True False 1189690.103951436 1829911.059595124 8282870.539190399 1.0 1.5381409440300955 6.9622084874705426 20.18215439183482 -6.926066623796464 0.7783948547938301 0.9043905557097685 7.971867426016869 0.9957072473021038 0.1764264414237098 0.0947321092147764 0.08806521956979425 0.1571200740869264 0.5018162060676187 1.1855868569396041e-07 6.926066623796464 7.067476870307101 up DK(ub)WLAPDGLIFPDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKWLAPDGLIFPDR 14 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;E9PNR9;H0YDE4 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 19391800.0 2247700.0 5059100.0 12085000.0 True False 1869062.1399933929 5031845.624147269 14611917.625273315 1.0 2.692176742804847 7.817780539562461 20.83388310393428 -6.951234135036907 0.5451262141698745 0.9269790675235711 9.821767653642127 0.99929461039373 0.0769846545192454 0.08299392432302531 0.03394044142619037 0.08409060644019717 0.42483601243352054 1.1188345394166458e-07 6.951234135036907 8.894788586118555 DK(ub)WLAPDGLIFPDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKWLAPDGLIFPDR 14 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;E9PNR9;H0YDE4 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 29285300.0 3065500.0 7016800.0 19203000.0 True False 3968350.1800389173 6626308.911737076 15708251.03941904 1.0 1.6697893610971832 3.9583832894669064 21.9201079087371 -6.948494917055483 0.5751293832559277 0.9721146256535932 4.768312502227918 0.9990778210565605 0.038463123288201395 0.08409579002697953 0.038507340849535776 0.040514897810728284 0.19093184214779702 1.1259136464123698e-07 6.948494917055483 3.7961978765743245 DK(ub)YEPAAVSEQGDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKYEPAAVSEQGDKK 15 2 P05023-4;P05023;P05023-2 P05023-4 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 1 8176700.0 2883100.0 4077900.0 1215700.0 True False 3779772.019980114 3469493.215529699 1089911.025817842 1.0 0.9179107092146664 0.2883536414515223 21.84986778907131 -6.930892238843182 0.7394456622327388 1.0092642784271249 0.15612863287740014 0.9967104099565087 0.01823291251905314 0.09217767066943165 0.07543389542079232 0.01669992237104589 0.05668740676061518 1.1724862575733693e-07 6.930892238843182 -0.8531356455497248 down DK(ub)YEPAAVSEQGDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKYEPAAVSEQGDKK 15 2 P05023-4;P05023;P05023-2 P05023-4 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 1 6779100.0 2681200.0 2833500.0 1264400.0 True False 2596086.7736146776 3964931.326507294 933215.7088130733 1.0 1.5272722648583497 0.35947015265352805 21.307907175223384 -6.783960070287572 1.520403543952095 1.2970248181464519 0.3490399884077743 0.7811445736962336 0.22338398830507328 0.2444810523963354 1.1164668410319731 0.11569109981817138 0.2720973906925543 1.6445229162677346e-07 6.783960070287572 -0.9479848297386776 down DK(ub)YPNLQVIGGNVVTAAQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKYPNLQVIGGNVVTAAQAK 20 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 179296900.0 41391000.0 84492300.0 53413600.0 True False 54264001.83101422 71886378.18840581 47886873.05143039 1.0 1.3247526124643398 0.8824795709051626 25.693492110815207 -6.709922803675377 1.7954607060955672 1.199668679706851 0.8835210410696827 0.46470627369799056 0.13685097000758953 0.37525066515816385 2.358029649348556 0.060656376704088404 0.154111241008375 1.9501912175977277e-07 6.709922803675377 -0.3161476386371683 DK(ub)YPNLQVIGGNVVTAAQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKYPNLQVIGGNVVTAAQAK 20 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 426837100.0 138392000.0 129029800.0 159415300.0 True False 133998821.71195072 180552072.02151817 117659650.57351187 1.0 1.3474153706339314 0.8780648148267886 26.99764507382822 -6.708454095825917 1.8009346098980696 1.2139214095976392 0.8792269843664188 0.4576780882711674 0.14643476921421453 0.37818008514842316 2.3900781817964782 0.06473305146616118 0.16474790815279644 1.9567975871182612e-07 6.708454095825917 -0.3346944252312204 DK(ub)YPNLQVIGGNVVTAAQAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKYPNLQVIGGNVVTAAQAK 20 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 457839700.0 167388000.0 162680000.0 127771700.0 True False 253939833.7019747 133648482.97535852 102517567.49067438 1.0 0.5262997971882157 0.40370809886797676 27.919911476954653 -13.999999999999998 0.18977762924228106 3.537370100960207 0.31556257021703055 0.9994895310809414 0.005809196398505794 12.347118995377185 0.13814859072310826 11.584308961386538 0.08445732894893027 1.0000000000000041e-14 13.999999999999998 -3.2218075307431766 DK(ub)YPNLQVIGGNVVTAAQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKYPNLQVIGGNVVTAAQAK 20 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 201033700.0 41391000.0 73304700.0 86338000.0 True False 56694371.249716684 70065855.9677736 65946742.586925626 1.0 1.2358520682619571 1.1631973533396436 25.756702172338098 -10.129482432351628 4.3926481522967045 0.9999719853925584 1.1995247107509732 0.9095474398483729 0.029661163217851765 8.695566222786649e-06 1.7231740142267088e-06 0.02872360304040161 0.009573099256178523 7.421942196339565e-11 10.129482432351628 0.19955272535841484 DK(ub)YPNLQVIGGNVVTAAQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKYPNLQVIGGNVVTAAQAK 20 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 342499600.0 138392000.0 142994500.0 61113100.0 True False 115079079.80511865 142224160.24631408 73891566.65495162 1.0 1.2358819733974622 0.6420938260897092 26.778050349262497 -6.798935408821652 1.4604486673364512 1.1303227132563545 0.6341285948836684 0.8289774033479582 0.10095273650949504 0.2222821454262483 0.9361432155080084 0.054385081715131296 0.12655169377882394 1.5887830254586177e-07 6.798935408821652 -0.4961941183726861 DK(ub)YPNLQVIGGNVVTAAQAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKYPNLQVIGGNVVTAAQAK 20 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 435641300.0 167388000.0 173068000.0 95185300.0 True False 216687065.71076602 163436613.66100115 77862552.08365427 1.0 0.754251819899377 0.3593317941163375 27.691037799047102 -6.964087073804345 0.3733949941403912 1.0292245056068139 0.07053902685571865 0.9998930631955527 0.0027290358724749277 0.0782722027979781 0.015961128849622655 0.0051800334639510335 0.03348031866098194 1.0862078227159849e-07 6.964087073804345 -0.9586854787510952 down DKAPVQPQQSPAAAPGGTDEK(ub)PSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKAPVQPQQSPAAAPGGTDEKPSGK 25 2 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 18954900.0 7696500.0 7882100.0 3376300.0 True False 10090186.033012025 6706121.404185166 3026952.8637565053 1.0 0.6646182124140003 0.2999897973985053 23.266449437905532 -7.298843927714717 0.30733037199518004 1.0723091886213294 3.5341446368578316e-15 0.9998489190754946 0.003513656393163548 0.10405670282661343 0.021531618430478038 0.013104626310657732 0.048929543303317904 5.025231486786861e-08 7.298843927714717 -1.0723091886213258 down DKAPVQPQQSPAAAPGGTDEK(ub)PSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKAPVQPQQSPAAAPGGTDEKPSGK 25 2 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 25069700.0 7696500.0 12956000.0 4417200.0 True False 10542104.04009191 12383561.080237368 3373948.3350896207 1.0 1.1746764244729844 0.3200450614278139 23.329659499428423 -6.853471807384052 1.2183282376684434 1.093563397842499 0.2835439017071457 0.9451896887251763 0.08631110233895081 0.1536833117420242 0.43724603316191196 0.05538349984717387 0.12846947196913988 1.4012905480206826e-07 6.853471807384052 -0.8100194961353533 down DKAPVQPQQSPAAAPGGTDEK(ub)PSGK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKAPVQPQQSPAAAPGGTDEKPSGKER 27 3 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 2 21849500.0 12295000.0 6380200.0 3174300.0 True False 18652413.884900823 5241603.461269872 2546898.213654887 1.0 0.2810147519572769 0.1365452337360264 24.152859011819327 -13.999999999999982 0.2255984950075234 5.448232477042097 0.06329511005850136 0.9995041092798201 0.008409047202969432 13.158026556031219 0.1504236760077591 26.153615185826283 0.07710123274353205 1.0000000000000409e-14 13.999999999999982 -5.384937366983596 DKAPVQPQQSPAAAPGGTDEKPSGK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKAPVQPQQSPAAAPGGTDEKPSGKER 27 3 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 123290500.0 6851800.0 78056800.0 38381900.0 True False 8982776.15292559 66411029.70302331 34410509.173182376 1.0 7.393152024766194 3.8307209917476635 23.09872995227438 -9.421609077570672 10.733653782725886 0.9999999999970632 5.61193650825693 0.6908489841818023 1.4543563791252296 0.0 3.6339266306547395e-19 1.4081745089506335 0.4693915029835444 3.7878338641793723e-10 9.421609077570672 4.611936508259866 DKAPVQPQQSPAAAPGGTDEKPSGK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKAPVQPQQSPAAAPGGTDEKPSGKER 27 3 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 121487700.0 75186200.0 10495500.0 35806000.0 True False 72799455.23584509 14686407.88330946 26427334.44302501 1.0 0.20173788163291292 0.36301555220996606 26.117424318873347 -10.171626934845966 7.76839642798771 1.0000002634912717 0.2823767171656396 0.9635019787178454 0.065841333303076 3.0044523221941736e-07 3.2038678120189876e-08 0.06375061964128688 0.021250198947908774 6.735550011980257e-11 10.171626934845966 -0.7176235463256321 DKAPVQPQQSPAAAPGGTDEKPSGK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKAPVQPQQSPAAAPGGTDEKPSGKER 27 3 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 499300500.0 296021500.0 148167000.0 55112000.0 True False 449086257.5704901 121725441.21594515 44219089.04355228 1.0 0.2710513607663417 0.09846457845932081 28.74241733417063 -13.63328014720214 0.2103120601878592 4.578678090528915 1.5515812473184328e-13 0.9994547570897399 0.009123346027781327 11.095827191526011 0.14578477715446098 16.430852794734676 0.10147200736593158 2.3265899769282704e-14 13.63328014720214 -4.57867809052876 DKAPVQPQQSPAAAPGGTDEKPSGK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKAPVQPQQSPAAAPGGTDEKPSGKER 27 3 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 125494200.0 6851800.0 79567400.0 39075000.0 True False 9385095.62293273 76051849.17379427 29846289.774886128 1.0 8.10347088930661 3.180179613935518 23.16194001379727 -9.363051598199643 10.954687339120122 1.0000641027065331 5.641825251621065 0.5423837598095017 2.0099252469666413 0.0 0.0 1.9461018099965801 0.6487005840006481 4.3345937634674793e-10 9.363051598199643 4.641761148914532 DKAPVQPQQSPAAAPGGTDEKPSGK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKAPVQPQQSPAAAPGGTDEKPSGKER 27 3 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 232408600.0 75186200.0 133520600.0 23701800.0 True False 62520656.61341419 132801298.02603586 28657736.795258846 1.0 2.1241187348237562 0.4583722940157054 25.897829594307623 -6.7249256586845405 1.7417341572229221 1.6802785736998986 0.46024406493037995 0.5356111447226555 0.47276962136629685 0.34582271090351263 2.0528186381973583 0.2153169247353674 0.5373907502577389 1.8839715548742823e-07 6.7249256586845405 -1.2200345087695186 DKAPVQPQQSPAAAPGGTDEKPSGK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKAPVQPQQSPAAAPGGTDEKPSGKER 27 3 Q13200;C9JPC0;F8WBS8 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 535507800.0 296021500.0 201506300.0 37980000.0 True False 383205667.20612955 190292297.26672608 31068029.707708985 1.0 0.4965800705769997 0.08107403508465659 28.513543656263078 -8.022956771985115 0.4452449850436794 1.0448594876410013 1.0409457862480604e-17 0.9960804770579086 0.023522473254578163 0.09965493321902441 0.10548865550129533 0.04556137715387482 0.07984519299496878 9.485128699526732e-09 8.022956771985115 -1.0448594876410013 DKDDDEVFEK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKDDDEVFEKK 11 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 11485700.0 2999000.0 6188200.0 2298500.0 True False 2493801.3782267156 6154862.938338477 2779105.722936754 1.0 2.468064614959455 1.1144054002058945 21.24991513390701 -6.626907952804973 2.0913559425153254 1.969349828138645 1.1197514366830548 0.10652138966640656 0.6302147717019829 0.5671543695311057 4.722886944092061 0.24679257271450164 0.6984152816088497 2.3609785812999953e-07 6.626907952804973 -0.8495983914555902 DKDFAIDIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKDFAIDIIK 10 1 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 32669500.0 4861500.0 11727000.0 16081000.0 False True 6373473.578832972 9977377.311487984 14417092.379844323 1.0 1.5654536240055947 2.262046308268245 22.603648433031957 -6.9683225464664105 0.29552217743107967 0.8725747728708891 2.9766142508444076 0.999966180286118 0.0030016769861390957 0.07685087860387199 0.010968259611084849 0.011821259626254929 0.06277734761259186 1.0756660297525096e-07 6.9683225464664105 2.1040394779735183 DKDFAIDIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKDFAIDIIK 10 1 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 25914400.0 9048100.0 3885300.0 12981000.0 False True 8760873.01817954 5436720.551571832 9580886.67834744 1.0 0.620568354351237 1.093599537222638 23.062643210411103 -6.693146267622768 1.85530644733479 0.7628257776349899 1.0920268443375318 0.3851813671566291 0.1603716800339309 0.4099286174413925 2.7381573379671753 0.0690894758059903 0.17919890757962317 2.0269999238487245e-07 6.693146267622768 0.3292010667025419 DKDFAIDIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKDFAIDIIK 10 1 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 31127500.0 4861500.0 12796000.0 13470000.0 False True 6658927.927097619 12230630.409286603 10288663.42335805 1.0 1.836726653777958 1.5450930744406628 22.666858494554848 -10.146401229518096 4.87199001802077 0.9999520601544575 1.690909864112162 0.8821245309164825 0.11905891021615123 6.200080505842796e-05 1.0862820716970406e-05 0.11528625832098993 0.03842609803899408 7.138365326775814e-11 10.146401229518096 0.6909578039577046 DKDNTNVNADVQK(ub)LQQQLQDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKDNTNVNADVQKLQQQLQDIK 22 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 72398400.0 5082500.0 57367000.0 9948900.0 True False 6663206.719000015 48808067.21481461 8919483.264587592 1.0 7.325011705796141 1.3386172215179584 22.667785221725055 -6.633220575854859 2.068549120747227 5.157176543615705 1.3628902406025276 0.12924662678206067 2.7108859127499634 0.5506981275597747 4.494571637883873 1.0702612935735483 3.0029879924222063 2.3269091327345834e-07 6.633220575854859 -3.7942863030131777 DKDNTNVNADVQK(ub)LQQQLQDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKDNTNVNADVQKLQQQLQDIK 22 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 493829000.0 67717000.0 129972000.0 296140000.0 True False 65567360.9014117 181870497.395026 218572049.99043292 1.0 2.7737962134619063 3.333549604338688 25.966474491495784 -9.724203059449675 0.31162606030563544 1.0511656127959022e-22 3.5203878841643723 0.9987393560713929 0.035317918888761235 1.094935939204632 0.13225601982196192 1.254727661448785 0.18878131494026673 1.8871088030620456e-10 9.724203059449675 3.5203878841643723 DKDNTNVNADVQK(ub)LQQQLQDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKDNTNVNADVQKLQQQLQDIK 22 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 439596000.0 92997000.0 180110000.0 166489000.0 True False 141083247.99138874 147967963.29414693 133582376.1752791 1.0 1.0487989566498952 0.946833717518557 27.07197145380566 -6.776608445640918 1.5494955536599089 1.0277535305363574 0.9461161126475639 0.7550549889649563 0.020608365631053397 0.2558862108181838 1.2132982508795278 0.010478893970037357 0.024792598663447133 1.6725979276544034e-07 6.776608445640918 -0.08163741788879353 DKDNTNVNADVQK(ub)LQQQLQDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKDNTNVNADVQKLQQQLQDIK 22 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 165999500.0 5082500.0 47665000.0 113252000.0 True False 6961637.599398055 45559002.69292326 86504210.0981548 1.0 6.544293931195523 12.425842176219353 22.730995283247946 -7.351771650026577 0.31890831907499834 5.173824907919565e-20 16.90387454235725 0.9996876828516676 0.08244675430314709 0.12721917855657017 0.029528802449255015 0.27085316469677834 0.9807912000741414 4.448651139475245e-08 7.351771650026577 16.90387454235725 DKDNTNVNADVQK(ub)LQQQLQDIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKDNTNVNADVQKLQQQLQDIK 22 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 270424000.0 67717000.0 114734000.0 87973000.0 True False 56309685.87174996 114115905.16908416 106367747.55880581 1.0 2.0265768384677676 1.8889778181513441 25.74687976693006 -10.157383824233891 4.859060235683628 0.9999234715322588 1.957777328269036 0.9847562577829568 0.05617456482744833 4.691050815316684e-05 8.13475088715139e-06 0.05439512383175213 0.018130262836128487 6.960111159662685e-11 10.157383824233891 0.9578538567367773 DKDNTNVNADVQK(ub)LQQQLQDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKDNTNVNADVQKLQQQLQDIK 22 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 338631000.0 92997000.0 145540000.0 100094000.0 True False 120386449.7449288 137440571.06005797 81877919.05116966 1.0 1.1416614689714908 0.6801257053817115 26.84309777589811 -6.8243226982161245 1.353187176479553 1.0760378837262758 0.6690944464199794 0.8940145481754419 0.06284709552070317 0.18792339082679566 0.6749613657477347 0.036486248015036166 0.0840088499245643 1.4985709234211812e-07 6.8243226982161245 -0.40694343730629645 DKEGPSPK(ub)VEYVWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKEGPSPKVEYVWR 14 2 O00767 O00767 SCD Acyl-CoA desaturase 1 34523500.0 0.0 1676500.0 32847000.0 True False 0.0 2345935.1928320024 24243385.31112226 0.0 DKEGPSPK(ub)VEYVWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKEGPSPKVEYVWR 14 2 O00767 O00767 SCD Acyl-CoA desaturase 1 28185200.0 0.0 3067200.0 25118000.0 True False 0.0 3050676.384808467 30370057.66748984 0.0 DKEGYNSIHYAAAYGHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKEGYNSIHYAAAYGHR 17 1 H7C209;A0A2R8Y7Y4;Q8N8A2-4;Q8N8A2;Q8N8A2-2;H7C4A0;Q8N8A2-3 H7C209 ANKRD44 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B 0 4886400.0 1874700.0 1450900.0 1560800.0 False True 2567827.2518625734 1386794.4405153126 1192171.1856850209 1.0 0.5400653176764135 0.4642723473007304 21.292116719111448 -13.999999999999993 0.2537257589904208 4.259667451845318 0.4348593149943988 0.9995498157600212 0.005022421750509541 14.148779368683075 0.1593888096021366 23.558447971779167 0.03426812575228226 1.0000000000000164e-14 13.999999999999993 -3.824808136850919 DKENALMPNWLHLPVGYHGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKENALMPNWLHLPVGYHGR 20 1 P16930;P16930-2 P16930 FAH Fumarylacetoacetase 0 29665900.0 10626000.0 2978900.0 16061000.0 False True 10288683.446378328 4168390.3047582842 11854142.280328035 1.0 0.4051432164749495 1.1521534647371 23.29455504907706 -6.694599218794993 1.8503147342268083 0.6286704778542804 1.1497049029148987 0.39187876584346637 0.2513544072726642 0.4068821348690525 2.7043248394808144 0.10853749616852748 0.28098654470563045 2.0202298381267523e-07 6.694599218794993 0.5210344250606183 DKENALMPNWLHLPVGYHGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKENALMPNWLHLPVGYHGR 20 1 P16930;P16930-2 P16930 FAH Fumarylacetoacetase 0 22840700.0 10626000.0 3533700.0 8681000.0 False True 8835989.81161622 3514663.256715472 10496156.963591041 1.0 0.3977667846668322 1.1878869472882694 23.074960324511338 -6.703019600761539 1.8206768416931207 0.6271369388631108 1.1856293165681886 0.4316804621250031 0.25407338177385275 0.3892617320198802 2.510798311349529 0.11125644397284128 0.28499949336064523 1.9814375967105836e-07 6.703019600761539 0.5584923777050778 DKEVSDDEAEEK(ub)EDKEEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKEVSDDEAEEKEDKEEEK 19 3 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 12614900.0 5156000.0 4949800.0 2509100.0 True False 6759565.930775029 4211309.134169283 2249482.4009867157 1.0 0.6230147286523218 0.3327850373860911 22.68849917535461 -7.798839427209987 0.2238030712031951 1.1916052989186572 3.946172798442124e-11 0.9998247175258926 0.0036164225667639693 0.12398930614660197 0.03243704587381399 0.0529322500746609 0.08783966832592476 1.5891341945708066e-08 7.798839427209987 -1.1916052988791954 down DKEVSDDEAEEK(ub)EDKEEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKEVSDDEAEEKEDKEEEK 19 3 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 14346400.0 5156000.0 7260500.0 1929900.0 True False 7062312.53566087 6939707.102737205 1474097.3675381371 1.0 0.9826394778899158 0.20872729153442873 22.751709236877502 -6.911736782540567 0.8838193038002058 1.0226667739730306 0.10490416582919597 0.9915605132058436 0.033897489678201526 0.10328157750372136 0.13261955864515954 0.027992678193187313 0.07823521813495452 1.2253586403506369e-07 6.911736782540567 -0.9177626081438347 down DKEVSDDEAEEK(ub)EDKEEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKEVSDDEAEEKEDKEEEK 19 3 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 8123930.0 6417450.0 956660.0 749820.0 True False 5336394.016239083 951506.2826978577 906603.8952240325 1.0 0.17830510262217264 0.1698907337923629 22.347433762137502 DKFLK(ub)EQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKFLKEQIK 9 2 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 1 8215700.0 2626300.0 2775600.0 2813800.0 True False 3443104.733125381 2361491.299204062 2522654.9678755007 1.0 0.6858610127321004 0.7326686706929277 21.715278635118008 -10.131769000221222 5.164248511748194 1.0000095441422858 0.7092648417122719 0.9809305451814619 0.019109146344287644 2.0999308826291037e-06 3.530215812203095e-07 0.018502958539074056 0.006167450462471692 7.3829682331523e-11 10.131769000221222 -0.29074470243001393 DKFLK(ub)EQIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKFLKEQIK 9 2 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 1 10260400.0 3363800.0 3648900.0 3247700.0 True False 3257018.0102510243 5105924.798762124 2397029.941088435 1.0 1.5676685798764132 0.7359584544955253 21.63512026671473 -6.722972018976131 1.7487075477387848 1.3442678571541293 0.737042764831593 0.5264347244974957 0.23879469093546796 0.34959090692859085 2.0908206454844116 0.1083623071979031 0.2710747670853886 1.892465543790112e-07 6.722972018976131 -0.6072250923225363 DKFLK(ub)EQIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKFLKEQIK 9 2 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 1 43693000.0 9458500.0 9710500.0 24524000.0 True False 14349236.00897393 7977585.406517216 19676820.650748968 1.0 0.5559588957578007 1.3712800206535871 23.774470590282796 -6.758779021132169 1.6168195347173901 0.7416941059930012 1.3741092232905827 0.686100102952348 0.18673441216584483 0.2849517396694113 1.4677924612858613 0.091134510054179 0.21929699049584125 1.7426933696909507e-07 6.758779021132169 0.6324151172975815 DKFLK(ub)EQIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKFLKEQIK 9 2 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 1 5588400.0 2626300.0 2011980.0 950120.0 True False 3597314.083088858 1923084.0708718714 725721.2243356302 1.0 0.5345888700440086 0.2017397445909101 21.7784886966409 -8.132042851463883 0.296519352142851 1.1400360557245028 1.4947487391749417e-15 0.9991027003253091 0.009806737313612455 0.09037714757224512 0.06357867528343052 0.0725942262444077 0.09388789481036644 7.378314253437252e-09 8.132042851463883 -1.1400360557245013 down DKFLK(ub)EQIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKFLKEQIK 9 2 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 1 12737800.0 3363800.0 6064600.0 3309400.0 True False 2797148.7416068707 6031928.796071153 4001380.239063261 1.0 2.1564562178434628 1.4305210801069517 21.415525542149005 -10.26935745209706 5.6453705682755935 0.9999659143518759 1.793488648608807 0.6143510955603015 0.2963617793328887 0.00022208890556187059 2.874299791104224e-05 0.2869724149150187 0.09565035292918574 5.378269343770579e-11 10.26935745209706 0.7935227342569312 DKFLK(ub)EQIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKFLKEQIK 9 2 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 1 47686800.0 9458500.0 11027300.0 27201000.0 True False 12244214.704908842 10413621.061224239 22250697.10582918 1.0 0.8504931767530426 1.8172416640904399 23.545596912375245 -6.867411443354588 1.1476216528243566 0.9166244287629794 1.8711610085354964 0.9620349507494461 0.08278961774951803 0.1393653131522354 0.34466002629379994 0.056067426545427144 0.13218490502567698 1.357027212438907e-07 6.867411443354588 0.9545365797725169 DKFNECGHVLYADIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKFNECGHVLYADIK 15 1 P52272-2;P52272;A0A087X0X3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 165987000.0 42571000.0 51729000.0 71687000.0 False True 55810993.25815049 44011234.83806268 64269516.910260566 1.0 0.7885764482723195 1.1515565869431077 25.73404598621092 -6.748751655203798 1.6540476724011826 0.8755028268315318 1.152230477627181 0.6438354301455353 0.08883675839424567 0.3021853665499971 1.6261515559656072 0.04243136169760825 0.10316411085537527 1.783398285526595e-07 6.748751655203798 0.2767276507956492 DKFNECGHVLYADIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKFNECGHVLYADIK 15 1 P52272-2;P52272;A0A087X0X3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 34613300.0 27510000.0 7103300.0 0.0 False True 26636710.10821268 9939684.733220136 0.0 1.0 0.37315737164386203 0.0 24.666912570807565 -8.393280546624661 0.5237617811928095 1.0412780468638165 7.29004624775841e-20 0.9927157650641323 0.035214809038684465 0.1801294379118207 0.1803506081366415 0.06808226601075061 0.06911133020727193 4.04314627156504e-09 8.393280546624661 -1.0412780468638165 DKFNECGHVLYADIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKFNECGHVLYADIK 15 1 P52272-2;P52272;A0A087X0X3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 242856000.0 41966000.0 200890000.0 0.0 False True 63665490.125558995 165039609.9392658 0.0 1.0 2.5922930870991503 0.0 25.92400823581617 -6.741194652845299 1.686885656723678 1.9468178231495121 6.6369322438979085e-09 0.6071873504291689 0.6690327408217847 0.3163099764881518 1.7686075203212606 0.313962109328681 0.7680707096282644 1.8147021223776786e-07 6.741194652845299 -1.9468178165125798 DKFNECGHVLYADIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKFNECGHVLYADIK 15 1 P52272-2;P52272;A0A087X0X3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 159025000.0 42571000.0 64939000.0 51515000.0 False True 58310649.13801767 62069780.255444065 39348217.984728254 1.0 1.064467317256729 0.6748032917896948 25.79725604773381 -6.864404660863115 1.1631965783061902 1.0354813922167325 0.6542753743740553 0.9587776055887349 0.03462471377641598 0.14233764905373467 0.3634712788079464 0.023170488939560554 0.054387346157765665 1.3664550158201813e-07 6.864404660863115 -0.38120601784267727 DKFNECGHVLYADIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKFNECGHVLYADIK 15 1 P52272-2;P52272;A0A087X0X3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 30381400.0 27510000.0 2871400.0 0.0 False True 22875783.899638843 2855931.198271722 0.0 1.0 0.1248451729917247 0.0 24.44731784624184 -10.414049870506405 0.4241651573447928 1.5641458162390611 4.2784894662898617e-20 0.9990962623338903 0.013374903305384843 2.0409577154672065 0.2222730512264127 1.3097648729994227 0.030625558921097768 3.854340953092561e-11 10.414049870506405 -1.5641458162390611 DKFSFDLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKFSFDLGK 9 1 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 46712000.0 13763000.0 18514000.0 14435000.0 False True 18043426.281081583 15751783.367006755 12941404.670297425 1.0 0.8729929183972336 0.7172365419236592 24.10496998336873 -6.968388429643327 0.29415321281628215 1.0289608406872572 0.5564283847294855 0.9999669337084512 0.0006649224366496149 0.07682926142128044 0.010892588599338792 0.002662004601221095 0.014058175964925246 1.075502861848821e-07 6.968388429643327 -0.4725324559577717 DKFSFDLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKFSFDLGK 9 1 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 29490000.0 9927900.0 4446100.0 15116000.0 False True 9612744.248757707 6221450.916105204 11156666.129720349 1.0 0.6472086175505217 1.1606119793691765 23.196516920083393 -6.721759133989864 1.7527951568771252 0.78577447921982 1.1599029475608764 0.5209067122187427 0.14842447958875202 0.35190343138767555 2.1138106590098062 0.06720895043883639 0.16838364562851083 1.897758153552275e-07 6.721759133989864 0.3741284683410564 DKFSFDLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKFSFDLGK 9 1 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 38179300.0 13763000.0 9416300.0 15000000.0 False True 18851553.031090084 9000256.730459943 11457308.934697166 1.0 0.4774278657899787 0.6077647245190733 24.16818004489162 -10.141569002532414 7.828847604836111 1.000000087051092 0.5425962951545884 0.942598510581752 0.053209799760582877 8.084695099700147e-08 8.82555884392343e-09 0.05152017706204909 0.017173389027314072 7.218234674797653e-11 10.141569002532414 -0.4574037918965035 DKFSFDLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKFSFDLGK 9 1 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 20536100.0 9927900.0 6342200.0 4266000.0 False True 8255488.730542505 6308033.309771867 5158000.876244599 1.0 0.764101740752705 0.6247965498592164 22.97692219551767 -12.965120878744823 0.06227905691115748 2.325264759562107 9.016181377943912e-15 0.9999605008473506 0.0009732456300011088 8.639553572958615 0.055818637194243056 1.9985536549673115 0.5223935378750274 1.083625262727334e-13 12.965120878744823 -2.3252647595620983 DKGEIAQAYIGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKGEIAQAYIGLK 13 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;E7ERV5;Q9UES5;O95317 G3V394 MYO5A Unconventional myosin-Va 0 5146500.0 1436300.0 1996800.0 1713400.0 False True 1883003.2091489872 1698885.2234654366 1536113.8040933558 1.0 0.9022210983024497 0.8157786437271096 20.84460402802267 -6.972578050261012 0.1866220375493567 1.0612359478386026 0.6544105964868406 0.9999961249078699 0.00014802982463429449 0.07547481082357435 0.00593013684040188 0.0031415671492966983 0.009513175941678732 1.065177415583746e-07 6.972578050261012 -0.406825351351762 DKGEYTLVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKGEYTLVVK 10 1 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 13256600.0 3341800.0 2763500.0 7151300.0 False True 4381132.162037231 2351196.5720386305 6411352.076113474 1.0 0.5366641509726384 1.4634007464253689 22.062872305244976 -6.770774966814074 1.5715047383362795 0.7345030151798971 1.4687632956855654 0.7334951601301403 0.1953139387750198 0.26518634494760324 1.2926008443862738 0.09795803728574382 0.23301371837587923 1.6952159627276601e-07 6.770774966814074 0.7342602805056683 DKGEYTLVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKGEYTLVVK 10 1 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 9500700.0 3341800.0 2224300.0 3934600.0 False True 4577353.768749314 2126023.071223521 3005328.5156306326 1.0 0.46446553590382017 0.6565646151601231 22.126082366767868 -10.219380189209085 5.025134046817234 1.0000525078144122 0.5605150755316101 0.8746667035941292 0.07842412070733032 4.613978988933304e-05 7.167473998925413e-06 0.07594287157130199 0.02531127611985679 6.03420153224433e-11 10.219380189209085 -0.4395374322828022 DKGEYTLVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKGEYTLVVK 10 1 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 3604900.0 1335300.0 1221500.0 1048100.0 False True 1110361.1138199833 1214919.5370512337 1267252.8641331359 1.0 1.0941661428249565 1.1412979510543166 20.08259751832433 -13.999999999999261 0.08980288346041093 0.5174110764382549 1.2596728579972813 0.99984332517087 0.0007352282973903644 12.165413920249327 0.08702144674885288 1.1215274437485647 0.10637527868223287 1.0000000000017016e-14 13.999999999999261 0.7422617815590264 DKK(ub)DEEEDMSLD ddPTM_RPMI8226_Bortezomib_1h_R1 2 DKKDEEEDMSLD 12 2 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 87966900.0 36803000.0 33976000.0 17187900.0 True False 48249089.400759 28906913.23741068 15409460.985978857 1.0 0.5991183169760702 0.31937309444303114 25.5239983790398 -8.114623330786918 0.21292255699556326 1.2424455609809877 1.5125146498630321e-10 0.9997591938328805 0.0043345865292417265 0.09030997197740426 0.04154961075629012 0.08917943715992681 0.10701674445300323 7.680273205923158e-09 8.114623330786918 -1.2424455608297362 down DKK(ub)DEEEDMSLD ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DKKDEEEDMSLD 12 2 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 85244300.0 36803000.0 26134200.0 22307100.0 True False 50410063.66367863 24979504.629757594 17038622.409145538 1.0 0.4955261472473756 0.33800041441769046 25.58720844056269 -13.999999999999998 0.16295513561134728 3.5006084817706813 0.1880853618090327 0.9995289092795784 0.0061285455596734205 12.03070230557601 0.12766169952551185 9.507173536298186 0.13715909359490702 1.0000000000000041e-14 13.999999999999998 -3.3125231199616487 DKK(ub)DEEEDMSLD ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKKDEEEDMSLD 12 2 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 12547100.0 5119500.0 5604000.0 1823600.0 True False 4257091.08230465 5573810.13969309 2204906.328626265 1.0 1.3093001845465828 0.5179373158801668 22.021436526858288 -6.800697372196958 1.4529714801481202 1.1705086253860117 0.5068143751508382 0.8341990235696596 0.1325916470256441 0.21977663201807496 0.9159156413383543 0.07178597199527877 0.1668841770282964 1.582350278430385e-07 6.800697372196958 -0.6636942502351736 DKLENEQEK(ub)LHVEYNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKLENEQEKLHVEYNK 16 2 B4DG57;A0A0U1RRH6;O94880-2;O94880 B4DG57 PHF14 PHD finger protein 14 1 9696400.0 2753000.0 4292800.0 2650600.0 True False 3609209.6600899263 3652330.973203338 2376341.3383505587 1.0 1.0119475777731177 0.6584104449868258 21.78325152158852 -6.8990793037232745 0.967085618411233 1.0150724124806314 0.6219889121005157 0.9861022030660378 0.01932382215678664 0.11208563246349877 0.18127349558457093 0.015012055155643198 0.03888082139524731 1.2615971414127782e-07 6.8990793037232745 -0.39308350038011575 DKLENEQEK(ub)LHVEYNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKLENEQEKLHVEYNK 16 2 B4DG57;A0A0U1RRH6;O94880-2;O94880 B4DG57 PHF14 PHD finger protein 14 1 9270400.0 2828300.0 2923000.0 3519100.0 True False 2738517.164633149 4090169.1432436267 2597342.1392629584 1.0 1.4935707528389894 0.9484483693608318 21.384963492324736 -6.668294620315707 1.9435652871834699 1.3155100567580882 0.9506754900698042 0.2714311054014338 0.20974184909956897 0.4650580917982623 3.385203100235104 0.08693220657351605 0.23276632935157926 2.146373905081063e-07 6.668294620315707 -0.36483456668828396 DKLESEMEDAYHEHQANLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKLESEMEDAYHEHQANLLR 20 1 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 27235800.0 10374000.0 3444800.0 13417000.0 False True 10044683.048440501 4820326.604394678 9902685.198627802 1.0 0.47988837289824327 0.985863381738586 23.25992870596743 -10.857818105830534 10.54109856357501 1.00847148894466 0.7328758773184146 0.2709386197483131 0.2065634323765079 0.04070952225108269 0.0005491026856265896 0.19798573142406517 0.06666806112747144 1.3873367610288841e-11 10.857818105830534 -0.27559561162624535 DKLNNLVLFDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKLNNLVLFDK 11 1 P62851 P62851 RPS25 40S ribosomal protein S25 0 34954000.0 19204000.0 0.0 15750000.0 False True 18594379.531738136 0.0 11624602.510128044 1.0 0.0 0.6251675400239298 24.148363272262586 -10.193779169760981 7.063396410223111 1.0000013885530077 0.312583770011965 0.6171627180025541 0.25522357946826807 5.580761390291868e-06 6.373288648202826e-07 0.24711966704283542 0.08237305607000397 6.400602108346964e-11 10.193779169760981 -0.6874176185410427 DKLNNLVLFDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKLNNLVLFDK 11 1 P62851 P62851 RPS25 40S ribosomal protein S25 0 35483400.0 5986400.0 13901000.0 15596000.0 False True 8199733.856377075 13286807.855540257 11912546.009702468 1.0 1.6203950138219274 1.4527966661305567 22.967145653406583 -10.139140067349112 4.550757769418721 0.9999355976973189 1.536595839987713 0.9318227559356145 0.06842173897047278 47812011.41999997 3.9905806228597958 32502.68943813342 0.023422581155049492 7.258718136869808e-11 10.139140067349112 0.5366602422903942 DKLPNYEEK(ub)IK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKLPNYEEKIK 11 2 Q9BV57;Q9BV57-2 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 24339900.0 3527200.0 6700700.0 14112000.0 True False 5351020.272860698 5504907.732191944 11322757.014490679 1.0 1.0287585266891497 2.1159996481264387 22.35138256406427 -6.912576731789028 0.8780281102287442 0.9690165158875494 2.2645235098495844 0.9918573950412425 0.04687252486241012 0.10273888045023595 0.12971676700146234 0.038870670640816014 0.10931297985205969 1.2229910201045527e-07 6.912576731789028 1.295506993962035 up DKLPNYEEK(ub)IK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKLPNYEEKIK 11 2 Q9BV57;Q9BV57-2 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 4260760.0 1204900.0 968360.0 2087500.0 True False 1650384.0911981736 925574.6532617045 1594475.4934120195 1.0 0.5608237853224459 0.966123887109476 20.654370388935494 -10.468247103972908 8.889154280748777 1.0000044365528156 0.763473836215961 0.31228552381953056 0.16546307367938473 1.4548405081673844e-05 8.701771899266477e-07 0.16021193652308 0.05340297739771234 3.4021456004648616e-11 10.468247103972908 -0.23653060033685458 DKLSGEYEK(ub)FVSEDDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKLSGEYEKFVSEDDR 16 2 P34932;A0A087WYC1 P34932 HSPA4 Heat shock 70 kDa protein 4 1 5096100.0 1255200.0 1786000.0 2054900.0 True False 1719281.360504561 1707088.6144877987 1569574.941993945 1.0 0.992908231138396 0.9129250034638418 20.713374230596585 -6.924307596992538 0.7921148093205413 1.0015061647184347 0.8986557768844661 0.9952963751752677 0.002707807263686759 0.09570312382131942 0.09296030754295752 0.00238796126794186 0.007476361888725375 1.1903985878545418e-07 6.924307596992538 -0.1028503878339686 DKNSVNFK(ub)NIYVLQELDNPGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKNSVNFKNIYVLQELDNPGAK 22 2 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 109359700.0 7631700.0 8965000.0 92763000.0 True False 9879386.093297333 8466089.86913165 75881085.82875732 1.0 0.8569449345516993 7.6807490983917335 23.23598996460851 -6.902114449881778 0.9478235002451687 0.7325157404252954 8.428540452852904 0.9875886876428814 0.3546711888809128 0.10986492738177751 0.16878020785718703 0.27949856031193376 0.735217572232588 1.252810977416614e-07 6.902114449881778 7.696024712427608 up DKPANVQPYYLYGSKPLNIAYSHIYSSYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKPANVQPYYLYGSKPLNIAYSHIYSSYR 29 2 E7EW33;H7C229;E7EVJ5;Q96F07-2;Q96F07 E7EW33 CYFIP2 Cytoplasmic FMR1-interacting protein 2 0 22402600.0 7115200.0 7341400.0 7946000.0 False True 6889331.8706635665 10272859.304895235 5864704.225109679 1.0 1.491125626947882 0.851273292564552 22.715932646068136 -6.701655579537433 1.825122375822307 1.3044752626681948 0.8531259479074503 0.4253812171513578 0.20724815532825872 0.3920809666399829 2.5403197129389627 0.09055431469429641 0.23239350603166217 1.9876706294065077e-07 6.701655579537433 -0.45134931476074447 DKPANVQPYYLYGSKPLNIAYSHIYSSYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKPANVQPYYLYGSKPLNIAYSHIYSSYR 29 2 E7EW33;H7C229;E7EVJ5;Q96F07-2;Q96F07 E7EW33 CYFIP2 Cytoplasmic FMR1-interacting protein 2 0 12249800.0 2903300.0 2255100.0 7091400.0 False True 3976728.4687323924 2155462.2253815434 5416557.371967428 1.0 0.5420189591341675 1.3620636698119826 21.92315062752291 -6.75513084085587 1.630520966633942 0.7323667020388395 1.3643834730155169 0.6708083381471499 0.1925193275087571 0.291216815658851 1.5246759169205626 0.0932067861003094 0.2251054532378602 1.7573940802074646e-07 6.75513084085587 0.6320167709766774 DKPANVQPYYLYGSKPLNIAYSHIYSSYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKPANVQPYYLYGSKPLNIAYSHIYSSYR 29 2 E7EW33;H7C229;E7EVJ5;Q96F07-2;Q96F07 E7EW33 CYFIP2 Cytoplasmic FMR1-interacting protein 2 0 23299400.0 7115200.0 6431300.0 9752900.0 False True 5916604.056805167 6396653.310386907 11792186.297685394 1.0 1.081135943688778 1.9930666619684043 22.496337921502413 -6.924359494937839 0.7917140240446265 0.9828610823296521 2.155959700656203 0.9953089162064108 0.030837078817425447 0.09567396661424311 0.0928136050939978 0.02720247698037182 0.08521562659424275 1.190256344394797e-07 6.924359494937839 1.1730986183265508 DKPHVNVGTIGHVDHGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKPHVNVGTIGHVDHGK 17 1 P49411;H3BNU3 P49411 TUFM Elongation factor Tu, mitochondrial 0 39481400.0 7299100.0 4356300.0 27826000.0 False True 7067394.065825346 6095793.307804391 20537535.83789351 1.0 0.8625234776819412 2.905955950185875 22.75274692278157 -6.890802609912425 1.017646254328842 0.8923069266953558 3.0844833012061224 0.9814062206786862 0.12716434443458904 0.11849341834622655 0.21807472595354163 0.09511278296989017 0.23780783597987287 1.2858709651111793e-07 6.890802609912425 2.1921763745107663 up DKPHVNVGTIGHVDHGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKPHVNVGTIGHVDHGK 17 1 P49411;H3BNU3 P49411 TUFM Elongation factor Tu, mitochondrial 0 15153900.0 7299100.0 4536100.0 3318700.0 False True 6069525.054956523 4511663.128954648 4012624.826064919 1.0 0.7433305057815542 0.6611101840313043 22.533152198215845 -13.999999999999998 0.15926700901930094 2.26212264393813 0.5796262804795332 0.9995383136422661 0.003101241657798847 12.00488286813915 0.12609092367308328 4.680833314127089 0.07419755599943308 1.0000000000000041e-14 13.999999999999998 -1.682496363458597 DKPLK(ub)DVIIADCGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKPLKDVIIADCGK 14 2 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 1 21813200.0 10074000.0 2973500.0 8765700.0 True False 15282994.50805134 2442855.692938463 7033155.5528572 1.0 0.1598414297441202 0.46019486227990297 23.86542391299407 -10.43590790884929 5.999735293921555 1.000284730795129 0.310018146093936 0.8755657612576005 0.12261877536768721 0.00046719447839600276 4.392547574183132e-05 0.11877225969731235 0.03957503957761662 3.665152851355711e-11 10.43590790884929 -0.6902665847011931 DKPLK(ub)DVIIADCGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKPLKDVIIADCGK 14 2 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 1 10602500.0 5805500.0 3143800.0 1653200.0 True False 4827530.477257482 3126863.7254045573 1998876.476466845 1.0 0.647714963196033 0.41405776429243923 22.2028539365787 -8.313285539313082 0.15681584636819432 1.3786844541239285 1.626816178914044e-10 0.9999054871112342 0.002341370539123883 0.09413936230007333 0.03429483600290032 0.1346301980380709 0.132579696568836 4.8608750848803125e-09 8.313285539313082 -1.3786844539612468 down DKPLK(ub)DVIIADCGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKPLKDVIIADCGK 14 2 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 1 27506800.0 10074000.0 4620800.0 12812000.0 True False 13040991.588227717 4363648.417990345 10480347.462221367 1.0 0.3346101704359253 0.8036465165487969 23.63655023508652 -9.805687167677268 6.027567134894801 1.0000000272613356 0.5691283434919848 0.5294513871758406 0.19148328646829468 7.001402314927224e-08 1.420876438495188e-08 0.18540290594202885 0.06180096496372747 1.5642740195363612e-10 9.805687167677268 -0.4308716837693508 DKPLKDVIIADCGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKPLKDVIIADCGK 14 2 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 46782700.0 1718700.0 25757000.0 19307000.0 False True 2253232.3439144734 21914155.999999635 17309296.845821425 1.0 9.725653042033306 7.681984901632692 21.10356465525895 -10.057140564185588 8.252299822641701 0.9999998723802785 8.703818971832998 0.9498660152910535 0.8343240245940127 1.9533775196099506e-06 2.2755697610465052e-07 0.8078308112940211 0.26927692104944684 8.767170161131033e-11 10.057140564185588 7.703819099452719 DKPLKDVIIADCGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKPLKDVIIADCGK 14 2 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 52842700.0 1718700.0 27567000.0 23557000.0 False True 2354149.8361210865 26348998.788121615 17993321.771644045 1.0 11.192575079051316 7.643235573013269 21.16677471678184 -10.457923564095609 7.012617871754689 0.998670173452937 9.41790532603214 0.882350661174254 1.4490117856158864 0.03011967924931592 0.002328245591635952 1.402570598818466 0.46766654284571646 3.483986278594518e-11 10.457923564095609 8.419235152579203 DKPPLTDLGVLYDWK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKPPLTDLGVLYDWKER 17 2 A0A0U1RR27;Q7Z401;Q7Z401-2;H3BTW5 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 7534600.0 3583300.0 1695500.0 2255800.0 True False 3469550.102899255 2372521.9919156963 1664938.3074505937 1.0 0.6838125755650997 0.47987152745231254 21.726317169765615 -8.59849540762189 0.1250986818565321 1.5004312830181004 7.65208228071474e-09 0.9999447865984119 0.0015900086120972455 0.19977401543214937 0.03247961851431437 0.19703515956613404 0.1647700725265983 2.520603833223596e-09 8.59849540762189 -1.500431275366018 DKPPLTDLGVLYDWK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKPPLTDLGVLYDWKER 17 2 A0A0U1RR27;Q7Z401;Q7Z401-2;H3BTW5 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 24139300.0 5715900.0 4754400.0 13669000.0 True False 8671438.1882639 3905940.1737032514 10967316.158664484 1.0 0.4504374117536385 1.2647632284928088 23.04783985861958 -6.724879887404383 1.7415058385120834 0.6674163790267027 1.2638808802822268 0.53557878713955 0.2311300268973721 0.3459067173990742 2.052678075973915 0.10527112320187429 0.2627902360110363 1.8841701213716272e-07 6.724879887404383 0.5964645012555241 DKPSVEPVEEYDYEDLK(ub)ESSNSVSNHQLSGFDQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKPSVEPVEEYDYEDLKESSNSVSNHQLSGFDQAR 35 2 Q9Y450;E9PN23;G5E991;E9PMN1;E9PLR4;Q9Y450-2 Q9Y450 HBS1L HBS1-like protein 1 38373400.0 11253300.0 10790800.0 16329300.0 True False 10896070.15124498 15099622.71327861 12052166.461500566 1.0 1.3857861140471215 1.106102135376165 23.377304561085268 -10.241373587158968 4.746522517971945 0.9999383406306304 1.2459441247123149 0.5076419506489878 0.11418050616485696 7.45206240416846e-05 1.1910604787748832e-05 0.11058246472152354 0.03685159990284141 5.736228102666905e-11 10.241373587158968 0.2460057840816845 DKPSVEPVEEYDYEDLK(ub)ESSNSVSNHQLSGFDQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKPSVEPVEEYDYEDLKESSNSVSNHQLSGFDQAR 35 2 Q9Y450;E9PN23;G5E991;E9PMN1;E9PLR4;Q9Y450-2 Q9Y450 HBS1L HBS1-like protein 1 71589600.0 20084600.0 31286000.0 20219000.0 True False 30469806.580941778 25702768.861366317 16222705.787697505 1.0 0.8435488027496327 0.5324190603114779 24.8608770061919 -6.96015594104808 0.4332324927457983 1.0119430869322101 0.35202960497829805 0.9997759333261124 0.002909034664364912 0.07964549566374171 0.02092601740577038 0.00407027440913942 0.02581459934654914 1.0960845570983723e-07 6.96015594104808 -0.6599134819539121 DKPSVEPVEEYDYEDLK(ub)ESSNSVSNHQLSGFDQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKPSVEPVEEYDYEDLKESSNSVSNHQLSGFDQAR 35 2 Q9Y450;E9PN23;G5E991;E9PMN1;E9PLR4;Q9Y450-2 Q9Y450 HBS1L HBS1-like protein 1 33451300.0 11253300.0 16538600.0 5659400.0 True False 9357617.55571812 16449503.27914493 6842754.373890923 1.0 1.757873003593014 0.7312496298493787 23.157709836519544 -6.7089268986873085 1.7990111307522345 1.466429498076077 0.7337329860534451 0.4600321167779181 0.3194169057185074 0.37722592030082686 2.3792019201517203 0.1413292560640816 0.359513278359433 1.9546684417743707e-07 6.7089268986873085 -0.732696512022632 DKPSVEPVEEYDYEDLK(ub)ESSNSVSNHQLSGFDQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKPSVEPVEEYDYEDLKESSNSVSNHQLSGFDQAR 35 2 Q9Y450;E9PN23;G5E991;E9PMN1;E9PLR4;Q9Y450-2 Q9Y450 HBS1L HBS1-like protein 1 111306600.0 20084600.0 78005000.0 13217000.0 True False 25999910.626654558 73663953.17809416 10811641.61787228 1.0 2.8332387074659957 0.4158337993203874 24.63200332828435 -6.703922745182966 1.8167371987213952 2.1339783498266414 0.4224484269505125 0.43620905627237516 0.7732952482105326 0.3874554189860697 2.488779905589795 0.3392191053398186 0.8682288966514276 1.977321346199054e-07 6.703922745182966 -1.711529922876129 DKQPYEQK(ub)AAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKQPYEQKAAK 11 2 P26583 P26583 HMGB2 High mobility group protein B2 1 54872000.0 14348000.0 20662000.0 19862000.0 True False 18810366.94622963 17579310.139845204 17806870.769757353 1.0 0.934554343894329 0.9466519616900181 24.165024656950482 -10.311073832015134 7.822341763384422 1.0000002425199428 0.9406031527928117 0.9698262879512813 0.0049388317837752715 2.0887956135191273e-08 1.8401283479570494e-09 0.0047820228365861184 0.0015940011040234583 4.8856929330506345e-11 10.311073832015134 -0.05939708972713109 DKQPYEQK(ub)AAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKQPYEQKAAK 11 2 P26583 P26583 HMGB2 High mobility group protein B2 1 66170000.0 18261000.0 22711000.0 25198000.0 True False 17681314.550566014 31779620.736300386 18597887.876203578 1.0 1.7973562228880238 1.0518385283524194 24.07572220280296 -10.272390925478307 4.255474655769416 0.9996605568435312 1.424597375630928 0.30191551027144004 0.30435632434206555 0.0009829451001953373 0.00016806627852284468 0.29492445624722463 0.09823058128562358 5.340833935740426e-11 10.272390925478307 0.42493681878739686 DKQWHLEGSFPVLATEPPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKQWHLEGSFPVLATEPPK 19 1 P53674 P53674 CRYBB1 Beta-crystallin B1 0 7774500.0 2318900.0 2829400.0 2626200.0 False True 3040100.356259543 2407264.548914819 2354466.01628923 1.0 0.791837198386652 0.7744698333531663 21.535687518351004 -13.999999999999996 0.3518666324560406 3.5896059415079242 0.7721293398487682 0.9997582466950472 0.0015932049654929926 20.8469220298626 0.19108391340303246 40.38666742231016 0.005148937248057113 1.0000000000000082e-14 13.999999999999996 -2.817476601659156 DKSHEGVACVQK(ub)EK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKSHEGVACVQKEK 14 2 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 2517030.0 686750.0 994920.0 835360.0 True False 900335.9004964612 846481.8141677853 748924.9605389439 1.0 0.9401844508266528 0.8318283877450331 19.780103822068817 -6.961933975114898 0.40726761306687254 1.0054994047799342 0.7625101062966312 0.9998353192524406 0.0008931768507109392 0.07901743849458506 0.018631427689023938 0.0013944386117477395 0.009055078920672059 1.0916062784623551e-07 6.961933975114898 -0.24298929848330297 DKSHEGVACVQK(ub)EK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKSHEGVACVQKEK 14 2 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 2725880.0 1137100.0 671680.0 917100.0 True False 1101003.3829170712 939885.3267649268 676883.9975897404 1.0 0.8536625239740249 0.6147882995566818 20.07038747102408 -6.9638139359075515 0.3778552999263935 1.0168091997208955 0.44322309053784464 0.9998865689516129 0.0016909260026936534 0.07836576623148246 0.016293411690917674 0.0031159295782536263 0.02020567037655272 1.0868911789362498e-07 6.9638139359075515 -0.5735861091830508 DKSHEGVACVQK(ub)EK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKSHEGVACVQKEK 14 2 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 2347120.0 686750.0 534370.0 1126000.0 True False 940660.0337209282 510759.7664747178 860061.9906979334 1.0 0.5429801928060316 0.9143175641212514 19.84331388359171 -9.951946356168847 6.820429591628144 1.000000019291035 0.7286488784636402 0.4158792737392051 0.15159784702478862 4.450572185528812e-08 6.73451641757777e-09 0.14678399514822008 0.04892799473732468 1.1170012106751747e-10 9.951946356168847 -0.27135114082739475 DKSHEGVACVQK(ub)EK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKSHEGVACVQKEK 14 2 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 2593520.0 1137100.0 619980.0 836440.0 True False 945549.032071222 616640.0446836055 1011335.736738404 1.0 0.6521502574359974 1.0695751382909002 19.850792746458357 -6.685532949824931 1.8820811762678713 0.7810167941088836 1.0680679697453705 0.34969028350591214 0.14725160973882245 0.4263452765566008 2.9243493079194427 0.06266987114589768 0.16413412249772183 2.0628471536225995e-07 6.685532949824931 0.28705117563648697 DKSHEGVACVQK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKSHEGVACVQKEK 14 2 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 15066700.0 1412300.0 1913400.0 11741000.0 True False 1828250.1905949945 1806917.6079862237 9604258.472833356 1.0 0.9883316940326268 5.253251727931011 20.802032081750884 -6.906282297862279 0.92068160984566 0.8519274489234885 5.76274155168665 0.9894413272858934 0.2063079799904091 0.10692803343548252 0.152483137591423 0.16586180968887332 0.44687592938660964 1.240845477408809e-07 6.906282297862279 4.910814102763162 up DKTGSSAQK(ub)SLSEYNNFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKTGSSAQKSLSEYNNFK 18 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 26573400.0 8560300.0 9127400.0 8885700.0 True False 11222636.198063124 7765627.498326531 7966293.001653047 1.0 0.6919610830534428 0.7098415079184267 23.419908269137565 -10.121449008982905 4.780674116835141 1.0000187150629039 0.7009012954840022 0.9973268357437806 0.007299652893244715 1.468138470199486e-06 2.698050741812866e-07 0.007068304040852879 0.0023559528393871337 7.560508239290122e-11 10.121449008982905 -0.2991174195789017 DKTGSSAQK(ub)SLSEYNNFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKTGSSAQKSLSEYNNFK 18 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 50181000.0 9155000.0 10935000.0 30091000.0 True False 8864379.536193645 15301402.525271658 22209264.389349997 1.0 1.7261673490846563 2.5054505280001393 23.07958822228869 -6.9702264998831405 0.25272054432396224 0.7608232872243839 3.493698055497031 0.9999840949408249 0.0024515874507464158 0.07622928925307766 0.00876692250913267 0.017065384512064515 0.07435943114161839 1.0709606158448355e-07 6.9702264998831405 2.732874768272647 DKTGSSAQK(ub)SLSEYNNFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKTGSSAQKSLSEYNNFK 18 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 173244000.0 26737000.0 33187000.0 113320000.0 True False 40561983.736526564 27264520.558785494 90922252.3300795 1.0 0.6721693084806762 2.2415632558967498 25.273624875154 -6.852180787333904 1.22451752022658 0.8246788891028084 2.3069937015138677 0.9434233109951426 0.16077606782447298 0.15507025494361368 0.44634861377644086 0.10268020603654882 0.2379635813804767 1.4054623389776328e-07 6.852180787333904 1.4823148124110594 up DKTGSSAQK(ub)SLSEYNNFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKTGSSAQKSLSEYNNFK 18 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 27761000.0 8560300.0 8211700.0 10989000.0 True False 11725274.243409181 7848879.941539446 8393624.525559148 1.0 0.6693984105276966 0.715857416322457 23.483118330660457 -10.087545423564423 6.657388059057705 1.0000002588647248 0.6926279134252824 0.9831541132322965 0.018966809692363255 7.287895187686739e-08 9.988566792017998e-09 0.018364550115231422 0.006121511505767129 8.174375363542876e-11 10.087545423564423 -0.30737234543944236 DKTGSSAQK(ub)SLSEYNNFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKTGSSAQKSLSEYNNFK 18 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 34908000.0 9155000.0 12581000.0 13172000.0 True False 7612788.135266945 12513223.655867008 15926204.299553173 1.0 1.643711007521455 2.0920330392190425 22.859993497722968 -7.787808912713867 0.11717904406702141 2.2678001768329706e-19 3.38039579967426 0.9999878299151621 0.0015635396844283825 0.13399946052816747 0.01573556552389524 0.1856508640443655 0.24190957832348753 1.6300130720535166e-08 7.787808912713867 3.38039579967426 DKTGSSAQK(ub)SLSEYNNFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKTGSSAQKSLSEYNNFK 18 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 102533000.0 26737000.0 27249000.0 48547000.0 True False 34611573.56506298 25732569.196203884 39711944.13428502 1.0 0.7434671858484473 1.147360262590614 25.04475119724645 -6.735106479390455 1.7047027460543902 0.8465020912539899 1.1473483647862825 0.5827089551032103 0.1078041252161682 0.32675834865256936 1.862485483649677 0.050069812396952566 0.12352872208631013 1.8403207402559796e-07 6.735106479390455 0.30084627353229265 DKTIIMWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKTIIMWK 8 1 P63244;D6RAC2;D6REE5;D6RHH4;D6RBD0;E9PD14;D6RAU2;D6RGK8;D6R909 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 39855000.0 12352000.0 13299000.0 14204000.0 False True 16193591.616938166 11314841.039095974 12734306.334388953 1.0 0.6987233781578683 0.7863793675684108 23.94891966426104 -10.182745084429031 7.501711924134268 1.0000001904932692 0.7425513728631397 0.920009973287116 0.03578540782577242 1.14034681032795e-07 1.238866451898203e-08 0.0346490979518203 0.011549690712204762 6.565305135259854e-11 10.182745084429031 -0.2574488176301295 DKTIIMWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKTIIMWK 8 1 P63244;D6RAC2;D6REE5;D6RHH4;D6RBD0;E9PD14;D6RAU2;D6RGK8;D6R909 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 15806600.0 4469700.0 2624300.0 8712600.0 False True 4327811.820090081 3672196.6755437106 6430508.687602638 1.0 0.848511171048855 1.4858568151581026 22.04520633925483 -6.844001108004187 1.2636743751655297 0.919404697014609 1.5085372701466344 0.9311198210526695 0.07135213176847716 0.16417557898884877 0.5075234914785476 0.044243212904674124 0.10206466219695455 1.4321842453745615e-07 6.844001108004187 0.5891325731320254 DKTIIMWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKTIIMWK 8 1 P63244;D6RAC2;D6REE5;D6RHH4;D6RBD0;E9PD14;D6RAU2;D6RGK8;D6R909 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 47011500.0 8121700.0 31797000.0 7092800.0 False True 12321212.67580309 26122576.918905098 5690904.97111533 1.0 2.1201303480627116 0.4618786414012126 23.55464091986034 -6.724756651922194 1.7419700908228843 1.6780139837923893 0.4637183677017349 0.5348290918557057 0.4711067657309168 0.3462265181275754 2.0556133896971485 0.2145178675007662 0.5355774387107016 1.8847048496960812e-07 6.724756651922194 -1.2142956160906544 DKTIIMWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKTIIMWK 8 1 P63244;D6RAC2;D6REE5;D6RHH4;D6RBD0;E9PD14;D6RAU2;D6RGK8;D6R909 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 29319300.0 12352000.0 8286800.0 8680500.0 False True 16918868.200248856 7920661.77521696 6630344.680509252 1.0 0.46815553389679204 0.3918905568643018 24.012129725783932 -13.999999999999998 0.2735548617261083 5.184456353301016 0.36743495590466974 0.9995910205500496 0.00547013312209447 15.060370385122244 0.16560243115476966 35.12153308282058 0.031121690115199937 1.0000000000000041e-14 13.999999999999998 -4.8170213973963465 DKTIIMWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKTIIMWK 8 1 P63244;D6RAC2;D6REE5;D6RHH4;D6RBD0;E9PD14;D6RAU2;D6RGK8;D6R909 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 11433000.0 4469700.0 4633300.0 2330000.0 False True 3716753.591283738 4608339.493261957 2817192.2272972143 1.0 1.2398829731594532 0.757971212808912 21.825611614689105 -6.771342291030553 1.5691656736191364 1.1373518881448559 0.7551116674123898 0.7357407751869668 0.10113661467133198 0.264254218386512 1.284276282458872 0.05079593518176344 0.12077452948698378 1.6930029270644643e-07 6.771342291030553 -0.3822402207324661 DKTIIMWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKTIIMWK 8 1 P63244;D6RAC2;D6REE5;D6RHH4;D6RBD0;E9PD14;D6RAU2;D6RGK8;D6R909 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 37960700.0 8121700.0 16223000.0 13616000.0 False True 10513700.752641337 15320175.788836896 11138027.711958012 1.0 1.457163005613227 1.0593822264876454 23.32576724195279 -10.332362037216956 6.082258406742257 0.999977544033658 1.2582726160504365 0.35983308713562323 0.16239332305740292 4.9454278771057736e-05 5.428503266226693e-06 0.15725031356145067 0.05241221964471676 4.6519813267454085e-11 10.332362037216956 0.2582950720167785 DKTIIMWK(ub)LTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKTIIMWKLTR 11 2 P63244;D6RAC2;D6REE5;D6RHH4;D6RBD0;E9PD14;D6RAU2;D6RGK8;D6R909 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 29093600.0 10171000.0 9452000.0 9470600.0 True False 9848127.17232392 13226232.89152883 6989965.74809007 1.0 1.3430201154081725 0.7097761458375448 23.231417961294436 -6.759570146814727 1.6139016242932123 1.199347704105869 0.7074957856280171 0.689302247069587 0.14426702002930683 0.2836299166298517 1.4559066917268473 0.07053031174486737 0.169580092580387 1.739521709522165e-07 6.759570146814727 -0.49185191847785203 DKTIIMWK(ub)LTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKTIIMWKLTR 11 2 P63244;D6RAC2;D6REE5;D6RHH4;D6RBD0;E9PD14;D6RAU2;D6RGK8;D6R909 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 118217000.0 31625000.0 33527000.0 53065000.0 True False 47977437.09719303 27543844.902353384 42576679.49078425 1.0 0.5740999638341429 0.8874313024376878 25.51585275669228 -9.970244441626742 5.651599086875579 1.0000004077227225 0.7307656331356873 0.4960811139208432 0.12791698333445645 6.571398767550466e-07 1.1968449853276428e-07 0.12385527386096815 0.04128502884583628 1.0709163728146437e-10 9.970244441626742 -0.26923477458703515 DKTIIMWK(ub)LTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKTIIMWKLTR 11 2 P63244;D6RAC2;D6REE5;D6RHH4;D6RBD0;E9PD14;D6RAU2;D6RGK8;D6R909 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 17560100.0 6416700.0 7607200.0 3536200.0 True False 8789127.394797338 7271088.750353625 2701022.390325073 1.0 0.8272822117310183 0.3073140562194973 23.06728850765191 -6.951372005480238 0.543572472974001 1.00748049890422 0.10295615475554595 0.9993046018160023 0.0077632948444605184 0.08293944654176184 0.03371816084073119 0.008497459008947054 0.04308606374826356 1.1184794123350686e-07 6.951372005480238 -0.9045243441486741 down DKTIIMWK(ub)LTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKTIIMWKLTR 11 2 P63244;D6RAC2;D6REE5;D6RHH4;D6RBD0;E9PD14;D6RAU2;D6RGK8;D6R909 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 31625000.0 31625000.0 0.0 0.0 True False 40939185.92194766 0.0 0.0 1.0 0.0 0.0 25.28697907878473 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 DKVAGHSLGYGFVNYVTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKVAGHSLGYGFVNYVTAK 19 1 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 0 6862800.0 4119400.0 0.0 2743400.0 False True 5400573.292326347 0.0 2459539.2845510165 1.0 0.0 0.455421887903228 22.364681132543875 -10.107102369086599 10.872564047424465 1.0000000167226235 0.22771094281577772 0.7931390049804967 0.18592520717631814 5.30820094748755e-10 0.0 0.18002130775851086 0.06000710258617028 7.814435860494406e-11 10.107102369086599 -0.7722890739068458 DKVQAGDVITIDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKVQAGDVITIDK 13 1 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 0 12273700.0 1790800.0 5034700.0 5448200.0 False True 2347756.142131869 4283542.385106895 4884472.526824681 1.0 1.8245261116502687 2.080485464043705 21.16285113500914 -10.648526348491947 0.242252715968995 5.49734167059067e-10 2.2201711116206773 0.9992025344102115 0.013018780158322654 2.385532062659978 0.12344538440032458 1.531155653904374 0.121567828378263 2.2463304877848766e-11 10.648526348491947 2.2201711110709432 DKVQAGDVITIDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKVQAGDVITIDK 13 1 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 0 8521000.0 1790800.0 3826300.0 2903900.0 False True 2452907.1545503265 3657241.4141179533 2218058.6276978026 1.0 1.4909824072768088 0.9042570663888104 21.226061196532033 -6.684708040266464 1.885094874422286 1.3093317746822979 0.9064003597943663 0.3457655308742148 0.20788014259031828 0.42818473412301966 2.9457221018862225 0.0883552783678279 0.23164051878743444 2.0667690994885462e-07 6.684708040266464 -0.4029314148879316 DKVSSK(ub)NSLESYAFNMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 DKVSSKNSLESYAFNMK 17 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 193002000.0 61218000.0 65374000.0 66410000.0 True False 80257390.83595528 55620454.0258561 59538530.24970217 1.0 0.6930259437357408 0.7418448273679604 26.258130919143113 -10.300088756513626 5.621601663172239 1.000032846988904 0.7174353855518742 0.9781029303741434 0.019930225785221488 8.205779314784089e-06 1.0216804843672523e-06 0.01929959771034286 0.006432452712691066 5.010848167462241e-11 10.300088756513626 -0.2825974614370297 DKVSSK(ub)NSLESYAFNMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 DKVSSKNSLESYAFNMK 17 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 252985000.0 81456000.0 80563000.0 90966000.0 True False 78870223.8667601 112732226.03049497 67139275.67849565 1.0 1.4293382280864302 0.8512626487775385 26.23297740186781 -6.707811692439391 1.8030126702726943 1.2645344883760374 0.8527063854633568 0.45471328842665115 0.1809836993975444 0.3794839580799936 2.4034011810705342 0.07992208522297577 0.2035797158844023 1.959694201321629e-07 6.707811692439391 -0.4118281029126807 DKVSSK(ub)NSLESYAFNMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 DKVSSKNSLESYAFNMK 17 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 884400000.0 253235000.0 325635000.0 305530000.0 True False 384176008.958346 267522890.0521321 245141861.58144358 1.0 0.6963550138841128 0.6380977881625682 28.51719218742687 -13.999999999999998 0.2321422642563362 2.9360205088579314 0.6103438679244882 0.999512792245198 0.0035021436441779706 13.359005607862082 0.15254160259482769 11.935475680686665 0.02984295257995232 1.0000000000000041e-14 13.999999999999998 -2.3256766409334433 DKVSSK(ub)NSLESYAFNMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DKVSSKNSLESYAFNMK 17 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 209034000.0 61218000.0 56272000.0 91544000.0 True False 83851948.95424493 53785716.973380454 69923192.60786106 1.0 0.6414366946047901 0.8338886988305507 26.321340980666005 -10.128697455339628 5.683577603335158 1.0000029291686898 0.7376626967176463 0.7124372344467245 0.07856820172159626 2.916249977824747e-06 4.469740741068149e-07 0.07607418428113996 0.02535777806742151 7.43536931239252e-11 10.128697455339628 -0.26234023245104354 DKVSSK(ub)NSLESYAFNMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DKVSSKNSLESYAFNMK 17 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 230430000.0 81456000.0 86707000.0 62267000.0 True False 67734273.11264922 86239892.18100803 75286741.80992085 1.0 1.2732090892535604 1.1115014356869393 26.013382677302086 -10.254959620545762 3.8800193148420044 0.999758317787103 1.1923552625013236 0.6535747480016088 0.06601687334478201 62211321.58649352 37744753.507512875 152567.3689457301 0.024159702385849764 5.559559460553616e-11 10.254959620545762 0.19259694471422062 DKVSSK(ub)NSLESYAFNMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DKVSSKNSLESYAFNMK 17 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 788135000.0 253235000.0 330334000.0 204566000.0 True False 327817699.5081242 311950622.51307625 167337087.0244127 1.0 0.9515978636331847 0.5104577552569447 28.288318509519318 -6.92775598001326 0.7649981520105501 1.0072967781481477 0.4248638995488128 0.9960782611612731 0.013793020957908922 0.09382031221947407 0.0835153960336357 0.012402179229274078 0.04041946060681505 1.1809840167661836e-07 6.92775598001326 -0.5824328785993349 DKVYEQLAK(ub)YLQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKVYEQLAKYLQLR 14 2 Q9UBK9-2;Q9UBK9;S4R2Z4 Q9UBK9-2 UXT Protein UXT 1 35542000.0 1124000.0 14181000.0 20237000.0 True False 1705190.1754069582 11650289.75334127 16237148.079807805 1.0 6.8322524498247414 9.522191902104217 20.70150121755681 -8.691627880361388 0.39526636407572924 1.2976956624509527e-16 10.117540573174347 0.9971589098996623 0.18960181680122792 0.2809801068817447 0.1310454641251047 1.140687997627406 0.6770487607858116 2.034099156150821e-09 8.691627880361388 10.117540573174347 DKVYEQLAK(ub)YLQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKVYEQLAKYLQLR 14 2 Q9UBK9-2;Q9UBK9;S4R2Z4 Q9UBK9-2 UXT Protein UXT 1 32866000.0 1124000.0 15118000.0 16624000.0 True False 1455040.1573523867 14276670.010209952 13598602.5766444 1.0 9.811873533571745 9.34586066778296 20.47262753964926 -9.717554738852265 6.400471997143243 0.9999999468901927 9.578867100687285 0.9977918064795929 0.19024895582801615 1.4236445692383748e-07 3.0877954853389366e-08 0.18420775937297504 0.06140258645769673 1.916219525546954e-10 9.717554738852265 8.578867153797093 DKYEPAAVSEQGDK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKYEPAAVSEQGDKK 15 2 P05023-4;P05023;P05023-2 P05023-4 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 1 6583310.0 3216700.0 2549300.0 817310.0 True False 4217124.850567113 2168954.377093567 732742.6013911166 1.0 0.5143206459258348 0.17375406879229066 22.007828303444825 -8.183902443041658 0.3166136401927949 1.1271286534656562 1.0053541845203776e-24 0.9987907240040991 0.011790104346946157 0.09238059447423999 0.07220389026032198 0.0744907257370867 0.09203745082192608 6.547832436023108e-09 8.183902443041658 -1.1271286534656562 down DKYEPAAVSEQGDK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKYEPAAVSEQGDKK 15 2 P05023-4;P05023;P05023-2 P05023-4 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 1 10797700.0 4966800.0 2614300.0 3216600.0 True False 7534998.7217182135 2147757.739380872 2580837.6001141374 1.0 0.28503757183002104 0.3425133427926616 22.845175836399967 -10.750626034641828 10.627384520299238 1.0015355827524521 0.3137754605059986 0.9947661723632198 0.023464385238590693 0.0008544147545819618 2.0048967258843433e-05 0.022738015916301632 0.007573097771504799 1.775717870436208e-11 10.750626034641828 -0.6877601222464536 DKYPNLQVIGGNVVTAAQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DKYPNLQVIGGNVVTAAQAK 20 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 64627000.0 11213000.0 36018000.0 17396000.0 False True 14700351.586846454 30644254.797064357 15596028.794215005 1.0 2.084593325270135 1.0609289650031215 23.809347324479575 -6.632634566225526 2.0716233910683024 1.7132051752299295 1.0651479853712458 0.12679440299434885 0.46493164918288493 0.5521792779894916 4.519681105522169 0.18337432979403756 0.5147505521567954 2.3300510366757387e-07 6.632634566225526 -0.6480571898586838 DKYPNLQVIGGNVVTAAQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DKYPNLQVIGGNVVTAAQAK 20 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 55031600.0 14395000.0 7948600.0 32688000.0 False True 13938038.604424626 11122517.431401417 24126032.181020025 1.0 0.797997318494338 1.7309488706223861 23.73252422005479 -6.85001051252678 1.2349394356471837 0.8921972628014008 1.7682725441823366 0.9403323978068935 0.09789388701787194 0.1574470955230079 0.46204831662027934 0.06202650306022586 0.1435427445135241 1.4125033531704914e-07 6.85001051252678 0.8760752813809358 DKYPNLQVIGGNVVTAAQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKYPNLQVIGGNVVTAAQAK 20 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 48409000.0 11213000.0 16100000.0 21096000.0 False True 15358749.119931199 15388648.7644197 16113559.285758067 1.0 1.0019467499765133 1.0491452891073885 23.872557386002466 -6.915574948465687 0.8568967565832231 0.9987834719037844 1.056032463748758 0.9928609183879652 0.0019198738217933728 0.10084599577463484 0.11962119912607885 0.0016165127658954565 0.004655101678804693 1.214576996491617e-07 6.915574948465687 0.05724899184497356 DKYPNLQVIGGNVVTAAQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKYPNLQVIGGNVVTAAQAK 20 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 28494600.0 14395000.0 8033200.0 6066400.0 False True 11970080.30662672 7989923.5571346525 7334856.192135544 1.0 0.6674912241575668 0.6127658298227887 23.512929495489065 -13.999999999999998 0.2539049049010753 3.358726996369615 0.5915647406395997 0.9995501640689094 0.0036291219108484157 14.15623206144986 0.15944547676358753 17.069973409957594 0.024718782112962447 1.0000000000000041e-14 13.999999999999998 -2.7671622557300153 DKYPNLQVIGGNVVTAAQAK(ub)NLIDAGVDALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DKYPNLQVIGGNVVTAAQAKNLIDAGVDALR 31 2 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 89511000.0 10290000.0 19092000.0 60129000.0 True False 15610682.29976654 15684883.433523161 48244476.79452305 1.0 1.0047532280993081 3.0904784216410937 23.896030259117214 -6.907397587388298 0.9132732497302805 0.9299873336586992 3.345542604664891 0.9899019109943139 0.09891584212914921 0.10616420520648667 0.1482877753355592 0.0799557970983566 0.2169305829840814 1.2376630134862066e-07 6.907397587388298 2.415555271006192 up DKYPNLQVIGGNVVTAAQAK(ub)NLIDAGVDALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DKYPNLQVIGGNVVTAAQAKNLIDAGVDALR 31 2 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 58616100.0 10290000.0 14374000.0 33952100.0 True False 13320607.846224248 13574074.264238521 27773166.17796487 1.0 1.0190281420292782 2.0849773898146267 23.667156581209664 -6.910770403740635 0.8904656038160422 0.967794524648045 2.225030816238726 0.9912091619439465 0.04753959287298553 0.10391108359165295 0.1360179870532026 0.03907010885132788 0.1084365413635524 1.2280883067831742e-07 6.910770403740635 1.2572362915906807 up DKYVK(ub)GLIEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DKYVKGLIEGK 11 2 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 3048960.0 1037100.0 741760.0 1270100.0 True False 1420543.896573678 708986.5905276992 970128.538530591 1.0 0.4990951650545682 0.6829275328066388 20.438011982612043 -10.057739780832913 5.033765404617496 1.000007389147972 0.5910113489284955 0.8684140408345923 0.0750492498740262 6.22363448686187e-06 1.1649663683385072e-06 0.072667436094022 0.024222041241240243 8.755082022806603e-11 10.057739780832913 -0.40899604021947644 DKYVK(ub)GLIEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DKYVKGLIEGK 11 2 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 3772000.0 1122800.0 1387300.0 1261900.0 True False 933657.9484738098 1379826.3395425105 1525757.4556336293 1.0 1.4778713572759952 1.6341717629327597 19.83253458066343 -11.626020019962322 0.1960915559686317 6.721159043243645e-11 1.7550317297268596 0.9994047228819903 0.006581836832404741 4.369840263660609 0.11878972908896128 1.9365308958474088 0.10132625430530111 2.365810636621601e-12 11.626020019962322 1.755031729659648 DLAEITTLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLAEITTLDR 10 0 Q9BS26 Q9BS26 ERP44 Endoplasmic reticulum resident protein 44 0 5298020.0 438020.0 1725900.0 3134100.0 False True 574248.4617917138 1468402.4475055065 2809813.3964100536 1.0 2.557085556527119 4.893027292825738 19.131315561576034 -6.965254973234843 0.353648727550155 0.7835283706034669 6.74585132712651 0.9999183057464249 0.014460574524815733 0.07787454708943492 0.014555437764477312 0.03177923762932551 0.20030422415899887 1.0832907299336304e-07 6.965254973234843 5.962322956523043 DLAGCIHGLSNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLAGCIHGLSNVK 13 0 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 15957700.0 4159100.0 2589400.0 9209200.0 False True 5452620.376781688 2203071.613402146 8256320.32488417 1.0 0.40403906033569675 1.5141931318089148 22.378518284730127 -6.760883690053916 1.6091141044147004 0.6542148100086507 1.5184317591407368 0.6945831892820002 0.25069543062450445 0.2814319450854294 1.4363834386627337 0.12291281250589116 0.29512519092194006 1.7342683961376614e-07 6.760883690053916 0.8642169491320861 DLAGCIHGLSNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLAGCIHGLSNVK 13 0 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 19709900.0 4159100.0 8363400.0 7187400.0 False True 5696831.665451335 7993877.333934642 5489884.149149495 1.0 1.4032145942478578 0.9636732260219516 22.44172834625302 -6.665451813171663 1.9534132290336068 1.2583691341546064 0.9654780151779118 0.2590796224020203 0.17145824759272127 0.47165609153974347 3.4651987928137635 0.0707727100426662 0.1902212430241921 2.1604697348245407e-07 6.665451813171663 -0.2928911189766946 DLAGSIIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLAGSIIGK 9 0 P61978;P61978-2;S4R359;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 17872200.0 2304100.0 8261800.0 7306300.0 False True 3020697.4129361394 7029171.644244166 6550314.1629784545 1.0 2.3270029014298923 2.1684774300553005 21.526450244048696 -10.064853148909249 4.570520748673743 0.9999345346341503 2.247740165796636 0.9880385193822906 0.06471775287183879 5072957.092799384 5585642.628906247 2745.366668749676 0.02215460828970263 8.612849353701742e-11 10.064853148909249 1.2478056311624854 DLAGSIIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLAGSIIGK 9 0 P61978;P61978-2;S4R359;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 18297400.0 8165600.0 2141800.0 7990000.0 False True 7906387.497623465 2997031.9093394484 5897179.305137965 1.0 0.3790646373252397 0.745875320038458 22.914587233715196 -10.435458863119607 5.915543306938587 1.0002001890478354 0.5624699786819376 0.6548169760363372 0.14974983414155452 0.00039554730933388473 3.774884355200407e-05 0.14505990737816984 0.048331551143963494 3.668944454657353e-11 10.435458863119607 -0.43773021036589777 DLAGSIIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLAGSIIGK 9 0 P61978;P61978-2;S4R359;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 21293700.0 2304100.0 8666600.0 10323000.0 False True 3155988.03596125 8283680.955386312 7884920.008858578 1.0 2.624750430292196 2.498399841511754 21.589660305571588 -10.18869710877865 4.8345893734551435 0.9998132560465508 2.561575135906824 0.9951138946260996 0.05158241188543216 0.00010383879167014389 1.742517761012917e-05 0.049950206054950055 0.016648151846745885 6.475941116679875e-11 10.18869710877865 1.5617618798602733 DLAGSIIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLAGSIIGK 9 0 P61978;P61978-2;S4R359;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 10711690.0 8165600.0 1681600.0 864490.0 False True 6790058.197415157 1672540.8870285358 1045250.8620498575 1.0 0.24632202529062852 0.15393842462907964 22.694992509149472 -13.999999999999998 0.29605719791163915 7.721338046632437 0.1302654601218077 0.9996410212830726 0.007179744314895329 16.336081162992457 0.1726929828945684 67.10895615401613 0.03396318845608631 1.0000000000000041e-14 13.999999999999998 -7.591072586510629 DLAGSIIGK(ub)GGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLAGSIIGKGGQR 13 1 P61978;P61978-2;S4R359;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 34653000.0 17575800.0 10446000.0 6631200.0 True False 23042044.004289303 8887497.51818909 5945067.034961978 1.0 0.38570786153062947 0.2580095339569396 24.457765364674664 -13.999999999999972 0.22079139499995398 4.719816035934284 0.1902192439089675 0.9994986977324032 0.007252088505510436 13.021269418734327 0.14885011883919055 21.127490765448584 0.0703043191073254 1.0000000000000655e-14 13.999999999999972 -4.529596792025316 DLAGSIIGK(ub)GGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLAGSIIGKGGQR 13 1 P61978;P61978-2;S4R359;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 54873500.0 20822000.0 24530000.0 9521500.0 True False 20161017.007386543 34324956.92226006 7027533.511122807 1.0 1.7025409437274006 0.34857038752301417 24.265065080554614 -6.765686520506175 1.5908926288077285 1.405179671463363 0.3421567095750404 0.7137927616256142 0.29578559672233906 0.2734757453476416 1.3652652902679618 0.14660754359549932 0.350396219755238 1.7151949111389938e-07 6.765686520506175 -1.0630229618883227 DLAGSIIGK(ub)GGQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLAGSIIGKGGQR 13 1 P61978;P61978-2;S4R359;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 55148000.0 17103000.0 12837000.0 25208000.0 True False 25946501.396783978 10546137.054061212 20225627.7509411 1.0 0.4064569975267797 0.7795127150918324 24.6290366841901 -10.525763781415685 6.834591477780119 1.0002335606903225 0.5929848563093467 0.6134712822475591 0.15229935894370247 0.0005423196742733814 3.763041732734728e-05 0.14754583881067845 0.04915440673558541 2.980136925064951e-11 10.525763781415685 -0.4072487043809758 DLAGSIIGK(ub)GGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLAGSIIGKGGQR 13 1 P61978;P61978-2;S4R359;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 37745100.0 17575800.0 12645000.0 7524300.0 True False 24074048.228135806 12086302.088576825 5747215.307822787 1.0 0.5020469334464209 0.2387307383186973 24.520975426197555 -9.148804103616182 0.2120692229571028 1.40424947740573 5.730474587461336e-13 0.9994646665041473 0.007303723508363228 0.5870444079102795 0.07431479743887641 0.29625237892699696 0.13319686398217268 7.098979080511869e-10 9.148804103616182 -1.4042494774051568 down DLAGSIIGK(ub)GGQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLAGSIIGKGGQR 13 1 P61978;P61978-2;S4R359;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 55401300.0 20822000.0 28899000.0 5680300.0 True False 17314415.571002524 28743315.350997597 6868024.467260238 1.0 1.6600800202078854 0.39666510481373246 24.04547035598889 -6.764712342674936 1.594525444953053 1.3811509283849566 0.39090697252232987 0.709998437348953 0.27785390809765825 0.2750630079032228 1.3792777617497605 0.1374176775861136 0.3287457139253203 1.7190466300914494e-07 6.764712342674936 -0.9902439558626267 DLAGSIIGK(ub)GGQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLAGSIIGKGGQR 13 1 P61978;P61978-2;S4R359;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 55583000.0 17103000.0 16193000.0 22287000.0 True False 22140170.650531907 15291845.315209007 18230994.683931246 1.0 0.6906832633126804 0.8234351474383624 24.40016300628255 -10.134609214484064 4.721238226303793 1.0000194772245767 0.7570592053742287 0.8170300427448272 0.054195729759121 1.137736211423293e-05 2.0854254421915914e-06 0.05247909511582148 0.017491596564777934 7.334842378033532e-11 10.134609214484064 -0.24296027185034808 DLAPGTNPPFLVYNKELK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLAPGTNPPFLVYNKELK 18 1 O15247 O15247 CLIC2 Chloride intracellular channel protein 2 1 28603200.0 7498900.0 11221000.0 9883300.0 True False 9831130.5194509 9546870.539115414 8860670.923307953 1.0 0.9710857281598412 0.90128708044076 23.228925896472397 -6.956207873830581 0.4859431779678699 1.0015851698628195 0.8678481625094905 0.9996026416630821 0.0008259493888970326 0.08108469538613312 0.026356505647229828 0.0009963088913989694 0.005756948971283019 1.1060942283655106e-07 6.956207873830581 -0.13373700735332905 DLAPGTNPPFLVYNKELK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLAPGTNPPFLVYNKELK 18 1 O15247 O15247 CLIC2 Chloride intracellular channel protein 2 1 34994800.0 8338800.0 12775000.0 13881000.0 True False 8074089.358428356 17876124.120744918 10245149.678926164 1.0 2.2140111815934316 1.268892282970771 22.944868122980356 -10.279935085423183 4.846747097839642 0.99976005574901 1.7414517322828833 0.45073058391291143 0.38584317465048723 0.001000714738288934 0.00014867365534725502 0.37370921369582827 0.12453034913871082 5.248859097853017e-11 10.279935085423183 0.7416916765338734 DLAPGTNPPFLVYNKELK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLAPGTNPPFLVYNKELK 18 1 O15247 O15247 CLIC2 Chloride intracellular channel protein 2 1 103277000.0 12036000.0 21551000.0 69690000.0 True False 18259491.94946455 17705055.671268445 55915740.953787886 1.0 0.9696357226296013 3.0622835021117654 24.12214328866922 -6.903610917187887 0.9381829119816613 0.9214038537249628 3.2987666433766694 0.9882780598823206 0.10603814706684075 0.10879515758622081 0.16281924766872777 0.08416082462502329 0.22321173613870807 1.2485015412403033e-07 6.903610917187887 2.3773627896517064 up DLAPGTNPPFLVYNKELK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLAPGTNPPFLVYNKELK 18 1 O15247 O15247 CLIC2 Chloride intracellular channel protein 2 1 27626600.0 7498900.0 9736700.0 10391000.0 True False 10271445.98015269 9306500.399038827 7936859.80936255 1.0 0.9060555268480788 0.7727110500993517 23.29213595799529 -6.966159436035235 0.3375724948733897 1.0148759382207702 0.6594755543635453 0.9999350752790754 0.0007513791690186945 0.07756979718274337 0.013485321798614272 0.0018966469555764787 0.011562303310023678 1.0810370134971696e-07 6.966159436035235 -0.35540038385722483 DLAPGTNPPFLVYNKELK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLAPGTNPPFLVYNKELK 18 1 O15247 O15247 CLIC2 Chloride intracellular channel protein 2 1 29860800.0 8338800.0 10070000.0 11452000.0 True False 6934081.671476137 10015750.91126149 13846560.251934627 1.0 1.4444235568297428 1.9968845058305973 22.725273398414632 -6.968190897724748 0.2982507184313196 0.9021709671464713 2.556405032590626 0.9999646316857661 0.002425066501668581 0.07689421580744966 0.011120188851043902 0.009245970003835908 0.04964037441437622 1.075992148436123e-07 6.968190897724748 1.6542340654441547 DLAPIGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLAPIGIR 8 0 Q99714 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 6301480.0 2558400.0 894680.0 2848400.0 False True 2477184.992397359 1251930.3896945633 2102318.5898316633 1.0 0.5053842944862086 0.848672423046246 21.240270180196962 -10.081691575816775 5.873650695085573 1.0000013041918336 0.6770283587662073 0.5413232457735792 0.14014679162125224 2.393563990623036e-06 3.7420867279304615e-07 0.13569709542349925 0.04523218249778118 8.28530354655725e-11 10.081691575816775 -0.3229729454256264 DLASVQALLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLASVQALLR 10 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 13773900.0 3755300.0 4835200.0 5183400.0 False True 4923234.666376927 4113807.007461985 4647071.490683726 1.0 0.83559027473484 0.9439061522743881 22.23117507671121 -10.315498731632742 5.866085780022963 1.0000106424551782 0.8897482135117976 0.5800824804968587 0.04421977183561482 6.1553087816699935e-06 7.182885930405049e-07 0.04281974211328992 0.014271869991035495 4.836166767138704e-11 10.315498731632742 -0.11026242894338067 DLASVQALLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLASVQALLR 10 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 11255200.0 3605300.0 2345800.0 5304100.0 False True 3490851.7249414404 3282490.1731853914 3914797.090410797 1.0 0.9403121163046407 1.1214446785122243 21.73514764857672 -6.817909401307386 1.3807594535048477 0.9677571424881092 1.1252281740041172 0.8795128728920187 0.026160523517000336 0.19622994193997353 0.7356464537494527 0.014890063479622915 0.034342069807134 1.5208647660642734e-07 6.817909401307386 0.15747103151600805 DLASVQALLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLASVQALLR 10 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 10840900.0 3755300.0 3108300.0 3977300.0 False True 5143735.893166648 2970965.028226444 3037943.6550647365 1.0 0.5775889528413215 0.5906103497849851 22.2943851382341 -9.881036236512932 5.46915601475084 1.0000003156471537 0.5840996513230511 0.9992653521809685 0.005315963050456567 7240294.468022425 4.556410034219332 28.78191240609099 0.0018197955471530947 1.315115097495168e-10 9.881036236512932 -0.41590066432410266 DLASVQALLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLASVQALLR 10 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 8272700.0 3605300.0 2302000.0 2365400.0 False True 2997966.6918708757 2289598.6690887753 2859994.203626104 1.0 0.7637171804800658 0.9539779782681075 21.515552924010997 -9.958890202436487 5.700335445608541 1.0000001640639817 0.8588475795099345 0.42325416179012165 0.07767364543965169 1.619311121179485e-07 2.9489763849335046e-08 0.07520727121890945 0.025069061268858654 1.099283723272464e-10 9.958890202436487 -0.14115258455404722 DLAVHIAHSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLAVHIAHSLR 11 0 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3;K7EQ85 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 0 28274000.0 8747700.0 8611300.0 10915000.0 False True 11468319.412847305 7326527.606584495 9785620.504073184 1.0 0.6388492805996495 0.8532741504488366 23.451150656054118 -10.271446034230282 5.573814476500888 1.0000220751437334 0.7460617155242366 0.65156960686311 0.0875385865488896 2.401566911509792e-05 3.1391304644763083e-06 0.08476623266841096 0.02825295732119555 5.352466598049279e-11 10.271446034230282 -0.2539603596194968 DLAVHIAHSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLAVHIAHSLR 11 0 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3;K7EQ85 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 0 27051100.0 9632800.0 4494300.0 12924000.0 False True 9327012.036728147 6288897.427464882 9538816.688310785 1.0 0.6742671074831147 1.0227087357396547 23.15298354855735 -10.113259981025449 12.925030278725178 1.0000008980804587 0.8484879216113848 0.20134186902386553 0.14225069906312232 0.0 0.0 0.13773364711403194 0.04591121570467731 7.704421224296253e-11 10.113259981025449 -0.1515129764690739 DLAVHIAHSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLAVHIAHSLR 11 0 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3;K7EQ85 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 0 81649000.0 17282000.0 30598000.0 33769000.0 False True 26218057.483436886 25137547.8367348 27094542.348521482 1.0 0.9587875780887013 1.033430579883285 24.644057463317043 -6.756779424937405 1.6242516104585962 0.9759668357584003 1.0336640882497803 0.6778529981445154 0.017327096701169206 0.28834354745711643 1.4984484672684815 0.008419469045035658 0.020300937964714025 1.75073564897738e-07 6.756779424937405 0.057697252491380024 DLAVHIAHSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLAVHIAHSLR 11 0 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3;K7EQ85 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 0 36095800.0 8747700.0 8281100.0 19067000.0 False True 11981961.087703759 7915213.620064337 14563767.297191374 1.0 0.6605941683609006 1.2154744278160894 23.51436071757701 -6.741211583687237 1.6825909891164075 0.7983328386286785 1.215864207804337 0.6102099349255183 0.14260018510793254 0.31563834565926985 1.7551224805172645 0.06703794346223711 0.16426578737201022 1.8146313781311008e-07 6.741211583687237 0.41753136917565836 DLAVHIAHSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLAVHIAHSLR 11 0 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3;K7EQ85 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 0 21702300.0 9632800.0 7384000.0 4685500.0 False True 8010100.005395901 7344220.926390754 5665216.386695754 1.0 0.9168700667211912 0.7072591332042613 22.933388823991628 -6.955277963474435 0.49753978204032684 1.0042888709999793 0.6108373711759717 0.9995530154888865 0.0026041205923432007 0.08143308151448478 0.027708034177021338 0.003068278358898484 0.017289745672799485 1.1084651321907951e-07 6.955277963474435 -0.3934514998240076 DLAVHIAHSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLAVHIAHSLR 11 0 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3;K7EQ85 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 0 89633000.0 17282000.0 39488000.0 32863000.0 False True 22371889.679149427 37290458.08725824 26882271.20285519 1.0 1.666844357900303 1.2016093226094098 24.415183785409493 -10.255131116125535 4.199684929509285 0.999677251716508 1.4342268402728766 0.5373629098836126 0.1899314078815956 134239334.94691312 232.61590290730186 419579.34714539215 0.06501857278835549 5.557364517516602e-11 10.255131116125535 0.4345495885563686 DLAVVTQSAEAPAEEDLLGPNCYYDK(ub)SK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLAVVTQSAEAPAEEDLLGPNCYYDKSK 28 1 Q9BX40-2;Q9BX40;Q5TBP9 Q9BX40-2 LSM14B Protein LSM14 homolog B 1 11220000.0 6352100.0 3126800.0 1741100.0 True False 5282052.595743209 3109955.3077787976 2105155.9600631674 1.0 0.5887778001841749 0.3985488447729026 22.33266723645586 -13.999999997068794 0.10330431061731081 3.0126384573548664 0.013364039153141506 0.9997770730664086 0.0037476941888098902 12.05609266540798 0.09636992607800292 5.131689733075937 0.34294325047211954 1.0000000067493502e-14 13.999999997068794 -2.999274418201725 DLCVK(ub)GWNWGTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLCVKGWNWGTVK 13 1 Q08945;E9PMD4;E9PPZ7 Q08945 SSRP1 FACT complex subunit SSRP1 1 50381500.0 18852900.0 23755000.0 7773600.0 True False 24716334.47174333 20210846.59626478 6969262.4416365735 1.0 0.8177121336244499 0.28196990332867133 24.558961466048 -6.951911528974712 0.5374472101674391 1.0080226871262943 0.06702664571740274 0.9993428897572622 0.007811834602519341 0.08272710112913516 0.03285487044861614 0.00862257402182775 0.04434943417766213 1.1170907894736682e-07 6.951911528974712 -0.9409960414088916 down DLCVK(ub)GWNWGTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLCVKGWNWGTVK 13 1 Q08945;E9PMD4;E9PPZ7 Q08945 SSRP1 FACT complex subunit SSRP1 1 45758100.0 29016000.0 14839800.0 1902300.0 True False 28094902.962555427 20765409.528534666 1404030.562223273 1.0 0.7391166132949657 0.049974565283053274 24.743805081574273 -7.3111372817974685 0.7056017014367236 0.9943244101798612 4.351878079943143e-18 0.9932159891085764 0.03300918829816968 0.10184981131428994 0.09939511123321668 0.029359218481736993 0.06549141742601365 4.8849791926689765e-08 7.3111372817974685 -0.9943244101798612 down DLCVK(ub)GWNWGTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLCVKGWNWGTVK 13 1 Q08945;E9PMD4;E9PPZ7 Q08945 SSRP1 FACT complex subunit SSRP1 1 117313000.0 53566000.0 29132000.0 34615000.0 True False 81263538.19915399 23933166.990645085 27773330.077706534 1.0 0.2945129823413749 0.34176865409972607 26.276104844818516 -9.940593681604028 7.09575747375037 1.0000000207206985 0.3181408182205493 0.9964106306411835 0.01929204721007305 6.328200166470043e-09 9.414485059457997e-10 0.018679444946401592 0.006226481463237647 1.1465851650137605e-10 9.940593681604028 -0.6818592025001492 DLCVK(ub)GWNWGTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLCVKGWNWGTVK 13 1 Q08945;E9PMD4;E9PPZ7 Q08945 SSRP1 FACT complex subunit SSRP1 1 49044200.0 18852900.0 21071400.0 9119900.0 True False 25823326.61046565 20140395.874198318 6965967.45023631 1.0 0.7799303388756985 0.26975484434345304 24.62217152757089 -6.957058155037937 0.4750833444080614 1.0128305402682134 0.015759991559016983 0.9996450475682971 0.005762505000667427 0.0807692460421212 0.02514500853596311 0.00712315317289611 0.042094265870561434 1.1039307860290605e-07 6.957058155037937 -0.9970705487091964 down DLCVK(ub)GWNWGTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLCVKGWNWGTVK 13 1 Q08945;E9PMD4;E9PPZ7 Q08945 SSRP1 FACT complex subunit SSRP1 1 48651200.0 29016000.0 8048600.0 11586600.0 True False 24128089.626751043 8005240.594277988 14009304.489614557 1.0 0.3317809539882719 0.5806222003619511 24.52421035700855 -10.269198379053272 5.6022880967169355 1.0000437800972157 0.4562015771752121 0.8642689999074248 0.10158901342899451 5.555524662230817e-05 7.247260713461658e-06 0.09837102555571493 0.03278771309733853 5.38023965288674e-11 10.269198379053272 -0.5438422029220036 DLCVK(ub)GWNWGTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLCVKGWNWGTVK 13 1 Q08945;E9PMD4;E9PPZ7 Q08945 SSRP1 FACT complex subunit SSRP1 1 120631100.0 53566000.0 41872000.0 25193100.0 True False 69342242.94371702 39541786.39155384 20608214.303035352 1.0 0.5702409485607309 0.2971956693088571 26.047231166910965 -8.464972956650486 0.20824733874658907 1.2959098344313058 5.779177858884496e-23 0.9996735805738626 0.005226560848683475 0.14379728845317769 0.05201616298656488 0.14168578340554508 0.12216155874639824 3.42789131228579e-09 8.464972956650486 -1.2959098344313058 down DLDEVLQTHSVFVNVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLDEVLQTHSVFVNVSK 17 0 Q9Y3A5;A0A087X020;F8WE72 Q9Y3A5 SBDS Ribosome maturation protein SBDS 0 13093400.0 4710500.0 3565800.0 4817100.0 False True 4560967.755897341 4989642.535401354 3555357.000097637 1.0 1.0939876803447546 0.7795181177285353 22.120908540315405 -6.82660276193765 1.3430818023804547 1.0503500212456636 0.7716317505334763 0.8988963736201545 0.04190762652817501 0.18504077634085908 0.6539976536926211 0.024507590954978273 0.05641139831190807 1.490723981433305e-07 6.82660276193765 -0.27871827071218724 DLDFEK(ub)AKPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLDFEKAKPR 10 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;A0A0A0MSA7;O43432;O43432-3;A0A0U1RQK7;O43432-4 Q04637-7 EIF4G1;EIF4G3 Eukaryotic translation initiation factor 4 gamma 1;Eukaryotic translation initiation factor 4 gamma 3 1 10652600.0 5281900.0 5121500.0 249200.0 True False 6924622.04999236 4357392.163450645 223415.17449519312 1.0 0.6292606487390099 0.032263879946406546 22.723303899477777 -7.566141259709896 0.6306421857545255 0.9997276814565762 3.2489869349809464e-15 0.9909785467292163 0.03786522853955252 0.11835458976615369 0.1205333678851734 0.03528323077272016 0.07475076407804071 2.7155558566835083e-08 7.566141259709896 -0.999727681456573 down DLDFEK(ub)AKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLDFEKAKPR 10 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;A0A0A0MSA7;O43432;O43432-3;A0A0U1RQK7;O43432-4 Q04637-7 EIF4G1;EIF4G3 Eukaryotic translation initiation factor 4 gamma 1;Eukaryotic translation initiation factor 4 gamma 3 1 13821400.0 5522500.0 4119100.0 4179800.0 True False 5347191.260363673 5763878.110822735 3084984.9886878184 1.0 1.0779263037676947 0.5769355982374198 22.35034984984663 -6.867163499876621 1.1489258308924324 1.043403997221672 0.5491258945541962 0.9617730270858761 0.04303588000806841 0.13960736696521794 0.34619561529425713 0.029116102914209397 0.06861738926582875 1.3578021753388053e-07 6.867163499876621 -0.49427810266747574 DLDFEK(ub)AKPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLDFEKAKPR 10 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;A0A0A0MSA7;O43432;O43432-3;A0A0U1RQK7;O43432-4 Q04637-7 EIF4G1;EIF4G3 Eukaryotic translation initiation factor 4 gamma 1;Eukaryotic translation initiation factor 4 gamma 3 1 37461800.0 8651800.0 10672000.0 18138000.0 True False 13125413.131304197 8767498.21928343 14553016.34983217 1.0 0.667978838576356 1.108766345428254 23.645859497512475 -6.705211366940475 1.8124304607565351 0.7948851310856103 1.1075837868618434 0.442235921727568 0.14002192100682162 0.384798523413423 2.4609201846843956 0.06155312843613575 0.15727950314419292 1.9714630105344788e-07 6.705211366940475 0.3126986557762331 DLDFEK(ub)AKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLDFEKAKPR 10 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;A0A0A0MSA7;O43432;O43432-3;A0A0U1RQK7;O43432-4 Q04637-7 EIF4G1;EIF4G3 Eukaryotic translation initiation factor 4 gamma 1;Eukaryotic translation initiation factor 4 gamma 3 1 12125800.0 5281900.0 3271500.0 3572400.0 True False 7234761.167980438 3126954.3125962107 2728672.695887476 1.0 0.4322125139991443 0.3771614062346687 22.78651396100067 -13.999999999999998 0.3299672338687721 7.179524708967978 0.3674081535003219 0.9997147739049637 0.004754684424056198 18.820471108618733 0.1836851455628251 80.71035639060777 0.017643411912535406 1.0000000000000041e-14 13.999999999999998 -6.812116555467656 DLDFEK(ub)AKPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLDFEKAKPR 10 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;A0A0A0MSA7;O43432;O43432-3;A0A0U1RQK7;O43432-4 Q04637-7 EIF4G1;EIF4G3 Eukaryotic translation initiation factor 4 gamma 1;Eukaryotic translation initiation factor 4 gamma 3 1 17407400.0 5522500.0 8577800.0 3307100.0 True False 4592203.438231756 8531589.688840015 3998599.3196972604 1.0 1.8578422762831983 0.870736537150657 22.130755125280906 -6.676974322909741 1.9128383063649543 1.544249708464386 0.8745992998920084 0.3101925120402107 0.3638198335742869 0.44531125374575703 3.147596217215931 0.1527728018542661 0.40446694725099 2.1039028265778753e-07 6.676974322909741 -0.6696504085723777 DLDFEK(ub)AKPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLDFEKAKPR 10 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;A0A0A0MSA7;O43432;O43432-3;A0A0U1RQK7;O43432-4 Q04637-7 EIF4G1;EIF4G3 Eukaryotic translation initiation factor 4 gamma 1;Eukaryotic translation initiation factor 4 gamma 3 1 33595900.0 8651800.0 9108100.0 15836000.0 True False 11199925.652474536 8601226.228336638 12954010.491081603 1.0 0.7679717254583975 1.1566157573750961 23.416985819604925 -6.744965840298367 1.6683945019086257 0.862752237221052 1.157107931909905 0.6271786576357051 0.09748439709749587 0.30885043401702916 1.6897719378625333 0.04618940791818023 0.11273806592480576 1.799012412000175e-07 6.744965840298367 0.2943556946888529 DLDLGAQRER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLDLGAQRER 10 1 P0DPI3;A0A0U1RR11 P0DPI3 0 7000300.0 2669400.0 2111600.0 2219300.0 False True 3499609.250506373 1796557.5109523349 1989668.1250288223 1.0 0.5133594588288345 0.568540080507825 21.73876241600254 -10.184145463876133 4.783689201496954 1.0000574201531338 0.5409497696681 0.9892790599510847 0.02252739447385783 31623311.031732365 2.150448676800577 20000.98946974031 0.00771172632096211 6.544169450108172e-11 10.184145463876133 -0.45910765048503377 DLDLGAQRER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLDLGAQRER 10 1 P0DPI3;A0A0U1RR11 P0DPI3 0 10535400.0 3695300.0 4386200.0 2453900.0 False True 3577994.724204953 6137632.533730829 1811149.9745779794 1.0 1.7153833381055752 0.5061913485577946 21.77071982944486 -6.746400820464074 1.663076163619328 1.4224639658105624 0.5044199906823083 0.6333753784220599 0.3005712086992107 0.3063656524921946 1.6659850180285785 0.14283833830921325 0.34810552364482406 1.7930779896152e-07 6.746400820464074 -0.9180439751282542 DLDLGAQRER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLDLGAQRER 10 1 P0DPI3;A0A0U1RR11 P0DPI3 0 7880300.0 2669400.0 2629100.0 2581800.0 False True 3656349.317822561 2512937.6687289346 1972032.0138400733 1.0 0.6872805222629674 0.5393445325991071 21.80197247752543 -13.999999999797529 0.09956410776426365 2.5463722486463305 0.22211657039059773 0.9997958988452569 0.002743420353831008 12.083750696574645 0.09388093135571396 3.8436627722278245 0.2829965419624454 1.0000000004662065e-14 13.999999999797529 -2.324255678255733 DLDLGAQRER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLDLGAQRER 10 1 P0DPI3;A0A0U1RR11 P0DPI3 0 7950000.0 3695300.0 2755100.0 1499600.0 False True 3072805.679546905 2740257.7294554673 1813159.4266330039 1.0 0.8917770972941989 0.590066413474073 21.551125104879137 -6.953086790799019 0.5238616674326805 1.0049780879909807 0.4633119868406697 0.9994217851073144 0.004170968737212534 0.08226942220003658 0.03101212910210686 0.004696648697610578 0.024931507415657757 1.1140718716558387e-07 6.953086790799019 -0.541666101150311 DLDLK(ub)KPIYQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLDLKKPIYQR 11 2 P31153 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 10633300.0 1985200.0 2083600.0 6564500.0 True False 1922180.9126435409 2915592.3458304587 4845060.519221306 1.0 1.516814742385875 2.520605884363913 20.87431269601375 -6.96061367476863 0.4266967266910456 0.9587024325007741 3.1170028524064484 0.9997922870327853 0.00909855239331878 0.07948262288261904 0.020326666002256976 0.013050015818329003 0.08341165501356153 1.0949299245167956e-07 6.96061367476863 2.1583004199056743 DLDLK(ub)KPIYQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLDLKKPIYQR 11 2 P31153 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 9738100.0 1985200.0 3145200.0 4607700.0 True False 1650781.7592716475 3128256.183326676 5571148.766402305 1.0 1.8950149925977586 3.374854813552331 20.654717971448026 -6.963588391994797 0.38150374471462206 0.9000523637049348 4.4222735405740226 0.9998810251944836 0.010681556844971147 0.07844329326049497 0.016569415324281123 0.019229920659588947 0.12495578347467064 1.0874557851324764e-07 6.963588391994797 3.522221176869088 DLDSLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLDSLHR 7 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 28047300.0 1243300.0 13142000.0 13662000.0 False True 1629978.3401343287 11181264.827114778 12248387.29515784 1.0 6.859762827396414 7.514447887785082 20.63642136274469 -9.656811547538373 0.5983119639060545 2.904441222082111e-20 7.447407530777048 0.9990775637825371 0.08895396512049301 0.9486732483192958 0.2753745690991205 2.197860145743529 0.11337891617602498 2.203882581578967e-10 9.656811547538373 7.447407530777048 DLDSLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLDSLHR 7 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 24588900.0 7597400.0 3783500.0 13208000.0 False True 7356224.6956065055 5294271.280691853 9748428.56849339 1.0 0.7196995061684085 1.3251945083074508 22.810534116812786 -6.780855591508438 1.5327980658309845 0.8414614839332196 1.3300976160115439 0.7703126669056196 0.11857715037614691 0.2492518549319766 1.156786757266177 0.06093013279637471 0.14365134396436494 1.6563206197874982e-07 6.780855591508438 0.48863613207832424 DLDSLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLDSLHR 7 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 32081300.0 1243300.0 15814000.0 15024000.0 False True 1702981.6089191556 15115285.190095196 11475640.628992671 1.0 8.875777114051472 6.738558166976333 20.699631424267583 -10.109676105667564 8.231053320372938 0.999999680360672 7.807167640513902 0.9311585457769161 0.8725159814904029 5.120295866412891e-06 5.505874109944016e-07 0.8448100167262461 0.28160332213434575 7.768262532053601e-11 10.109676105667564 6.8071679601532304 DLDVAILVGSMPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLDVAILVGSMPR 13 0 P40925;P40925-3;A0A5K1VW95;C9JF79;C9JRL4;C9JLV6 P40925 MDH1 Malate dehydrogenase, cytoplasmic;Malate dehydrogenase 0 36236500.0 9807500.0 14379000.0 12050000.0 False True 14878694.524291582 11812955.106360216 9668312.21829739 1.0 0.7939510477262564 0.6498091752950836 23.82674461230034 -7.294194161850134 0.08452408715331894 1.4861305403679763 2.570135934486415e-12 0.9999994727269531 0.00010419132097779195 0.10823596528952363 0.0046901877511710465 0.03287390905866156 0.0481166121963684 5.0793230837028e-08 7.294194161850134 -1.4861305403654061 DLDVAILVGSMPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLDVAILVGSMPR 13 0 P40925;P40925-3;A0A5K1VW95;C9JF79;C9JRL4;C9JLV6 P40925 MDH1 Malate dehydrogenase, cytoplasmic;Malate dehydrogenase 0 5714600.0 3010200.0 1036200.0 1668200.0 False True 2503114.6744708377 1030617.7849304042 2017012.9071146804 1.0 0.4117341468377905 0.805801239426268 21.255292955636357 -10.105344053387876 5.687494469790654 1.0000031921549313 0.608767693132015 0.5678888209079024 0.16087721687748027 6.511694450351369e-06 1.0247858043749841e-06 0.15576996482605968 0.051922898479198634 7.846138077007505e-11 10.105344053387876 -0.3912354990229163 DLDVAILVGSMPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLDVAILVGSMPR 13 0 P40925;P40925-3;A0A5K1VW95;C9JF79;C9JRL4;C9JLV6 P40925 MDH1 Malate dehydrogenase, cytoplasmic;Malate dehydrogenase 0 32928300.0 9807500.0 10889000.0 12231800.0 False True 12696002.08472734 10283017.57779972 10005737.908866635 1.0 0.8099413901459327 0.7881014702181752 23.59787093439279 -13.999999999999998 0.30536329858222666 2.7881991418931302 0.7830205734299487 0.9996617568575497 0.0017501301161824136 16.94644519249124 0.1756650756033149 19.204853511130175 0.007715201586754045 1.0000000000000041e-14 13.999999999999998 -2.0051785684631813 DLDVSIK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLDVSIKR 8 1 O43747;O43747-2 O43747 AP1G1 AP-1 complex subunit gamma-1 1 6890800.0 1128800.0 1316900.0 4445100.0 True False 1092966.8618738817 1842745.0375427771 3280794.959858418 1.0 1.6860026610353105 3.0017332403230643 20.059818229313894 -6.960855621529576 0.42320242785849327 0.9438087346474467 3.7938215044349164 0.999800628283682 0.011727628351882067 0.07939687839296806 0.02001236737612279 0.017057717240822636 0.1094300245476799 1.0943201056472599e-07 6.960855621529576 2.8500127697874698 DLDVSIK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLDVSIKR 8 1 O43747;O43747-2 O43747 AP1G1 AP-1 complex subunit gamma-1 1 25103400.0 3365900.0 9558500.0 12179000.0 True False 5106316.380251136 7852710.994098634 9771815.311754659 1.0 1.537842626530013 1.9136721237147605 22.28385149721391 -7.602946585023697 0.10217851003246722 2.1815751567293975e-14 3.224452169943435 0.9999958283927244 0.0007658049502848797 0.13961464261867604 0.010595259965103895 0.13542091778218718 0.18583449945132072 2.4949015623240422e-08 7.602946585023697 3.2244521699434134 DLDVSIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLDVSIKR 8 1 O43747;O43747-2 O43747 AP1G1 AP-1 complex subunit gamma-1 1 6086800.0 1128800.0 2575300.0 2382700.0 True False 938647.2143188779 2561426.3477429743 2880911.553639941 1.0 2.72884882485019 3.0692165381116614 19.84022350474817 -10.13404972840316 0.3745077826208823 6.060793784754844e-17 3.1199818376712325 0.9989585140164959 0.029236313699542854 1.5047432963386551 0.17055214867265606 1.684530363732331 0.09308836821478104 7.344297682844074e-11 10.13404972840316 3.1199818376712325 DLDVSIK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLDVSIKR 8 1 O43747;O43747-2 O43747 AP1G1 AP-1 complex subunit gamma-1 1 19393300.0 3365900.0 8593400.0 7434000.0 True False 4357223.901808181 8115169.735794284 6081088.279281423 1.0 1.86246332955867 1.3956336457159948 22.05497781930636 -10.384659253000445 5.237558877028505 0.999623469006697 1.629048487637356 0.7076855552950289 0.19058242036664105 0.0008384265640569032 9.850320888286744e-05 0.18463723528141102 0.06151021167997985 4.124209772587916e-11 10.384659253000445 0.6294250186306591 DLEAHIDSANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLEAHIDSANK 11 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 16541800.0 3539300.0 5490000.0 7512500.0 False True 4640056.574629954 4670913.399852389 6735178.564988518 1.0 1.0066500967663083 1.4515294063037691 22.14571096507368 -6.910153220031754 0.8946893421154062 0.9862912395330802 1.5092113882982345 0.990978828779004 0.02006952586730727 0.1043182063907665 0.13821961543596176 0.016443446581177617 0.04543976583755335 1.2298348058877314e-07 6.910153220031754 0.5229201487651544 DLEAHIDSANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLEAHIDSANK 11 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 12305200.0 2549200.0 1277400.0 8478600.0 False True 2468277.041361534 1787472.4815529974 6257800.307452164 1.0 0.7241782229465636 2.5352908942507844 21.235072902128774 -6.86807491079601 1.1442955466044586 0.8456953441563395 2.6375200884548895 0.9627203883144893 0.1538363246636945 0.13871058013819204 0.340676365178046 0.1044553567464544 0.24649749813934818 1.3549556779450357e-07 6.86807491079601 1.79182474429855 up DLEAHIDSANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLEAHIDSANK 11 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 15330100.0 3539300.0 4532800.0 7258000.0 False True 4847874.855986133 4332525.908034879 5543809.883202127 1.0 0.8936959052656023 1.143554660111875 22.20892102659657 -6.791104271089371 1.491925924021227 0.9406722141085667 1.146293264739812 0.8048848775439852 0.04522382650198036 0.2337064775797572 1.0276347364619305 0.023857952330476734 0.05581253388984701 1.617691594495066e-07 6.791104271089371 0.20562105063124536 DLEALLNSK(ub)EAALSTALSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLEALLNSKEAALSTALSEK 20 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 10700910.0 7280900.0 880710.0 2539300.0 True False 7049771.81486317 1232382.0958419773 1874181.1526328975 1.0 0.17481162911453707 0.2658499029261522 22.749145130822413 -10.515016372096659 6.24767494926981 1.000727596051942 0.2203307667472784 0.9898779112317658 0.037166219650373 0.0003769782219863596 2.926337800597292e-05 0.03601565191324272 0.011995345812281785 3.054805950524988e-11 10.515016372096659 -0.7803968293046636 DLEALLNSK(ub)EAALSTALSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLEALLNSKEAALSTALSEK 20 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 18936400.0 7280900.0 9670100.0 1985400.0 True False 6054390.948559815 9618005.251935432 2400537.960547588 1.0 1.5885999654884047 0.3964953669069908 22.52955040625669 -6.772438309851553 1.5649836770333505 1.3365543360358199 0.3891410496081085 0.739842279407189 0.24823808481903578 0.26250688002708406 1.2691379072787587 0.12499961614766317 0.2969070539323743 1.6887357219832082e-07 6.772438309851553 -0.9474132864277114 down DLEDHRDDK(ub)ESRPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLEDHRDDKESRPPR 15 3 Q15910-3;Q15910-4;Q15910;Q15910-2;Q15910-5;G3XAL2 Q15910-3 EZH2 Histone-lysine N-methyltransferase EZH2 1 2524890.0 884140.0 806760.0 833990.0 True False 856073.4596537682 1128903.475197821 615542.9998362969 1.0 1.3186993037424575 0.7190305842272556 19.70737507402001 -6.7623378908693645 1.6038877037318107 1.1845787971749566 0.7165979264162874 0.7003815329220631 0.13409309265736485 0.27899368798427787 1.4150536517819092 0.06595204213105668 0.15811561884185737 1.7284710466129214e-07 6.7623378908693645 -0.46798087075866923 DLEDHRDDK(ub)ESRPPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLEDHRDDKESRPPR 15 3 Q15910-3;Q15910-4;Q15910;Q15910-2;Q15910-5;G3XAL2 Q15910-3 EZH2 Histone-lysine N-methyltransferase EZH2 1 2322000.0 884140.0 907930.0 529930.0 True False 735201.5840431366 903038.8008800042 640735.91288052 1.0 1.2282873438790363 0.8715105173697858 19.487780349454287 -6.733848964983588 1.7092152318225307 1.136781000053399 0.8715663328045042 0.5771626903424973 0.09593973905587505 0.32899094408181384 1.8846002378786992 0.044451335571929144 0.10982479886033385 1.8456571735802631e-07 6.733848964983588 -0.26521466724889486 DLEDHRDDK(ub)ESRPPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLEDHRDDKESRPPR 15 3 Q15910-3;Q15910-4;Q15910;Q15910-2;Q15910-5;G3XAL2 Q15910-3 EZH2 Histone-lysine N-methyltransferase EZH2 1 7385900.0 1089700.0 1118200.0 5178000.0 True False 1410638.1311983045 1055971.1870232027 4235657.130766635 1.0 0.7485769480271879 3.002653222742917 20.42791651241005 -6.879211252638679 1.0842258991491593 0.8457528582260194 3.1599781974012 0.9730420007729598 0.16559395303175115 0.1283293274775936 0.2765479853045949 0.11773672234355162 0.28414708848291925 1.3206530763731433e-07 6.879211252638679 2.314225339175181 up DLEDK(ub)EGEIQAGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLEDKEGEIQAGAK 14 1 Q13409;Q13409-5;Q13409-2;Q13409-7;Q13409-3;Q13409-6;E7EQL5 Q13409 DYNC1I2 Cytoplasmic dynein 1 intermediate chain 2 1 4120500.0 2416000.0 1704500.0 0.0 True False 3309260.4899450447 1629189.553972257 0.0 1.0 0.492312273065972 0.0 21.65807742784093 -7.9527157268090125 0.5882456012705147 1.0118004393747715 1.1379861263444975e-18 0.9891898631328288 0.04244798488469513 0.1119861741424045 0.16264940118048732 0.04528447046425345 0.07675131584605523 1.115024148564156e-08 7.9527157268090125 -1.0118004393747715 DLEDLFYK(ub)YGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLEDLFYKYGR 11 1 Q13242;H0YIB4;S4R3G0 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 10454070.0 4488800.0 3757600.0 2207670.0 True False 5884860.26960103 3196980.7270100834 1979241.4858659862 1.0 0.5432551633425318 0.336327694319269 22.488576729575676 -12.454114840036825 0.12446283782030568 2.516243243130903 1.1221657604123717e-14 0.9997217301731067 0.0046252136452912505 6.718576029539515 0.09305752767003463 2.85020514790581 0.2664013178524367 3.514674900576716e-13 12.454114840036825 -2.516243243130892 DLEDLFYK(ub)YGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLEDLFYKYGR 11 1 Q13242;H0YIB4;S4R3G0 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 10246000.0 4488800.0 4802700.0 954500.0 True False 6148430.66525882 4590500.833594937 729066.7585445625 1.0 0.7466134178812762 0.11857769864171872 22.551786791098568 -7.2256542025082515 0.613163356549132 1.0007349837365653 2.4775351815670293e-22 0.9974422915981385 0.018738397657491957 0.09067912452331825 0.06081841019815553 0.017965746873879865 0.055460983555225475 5.9476553919586756e-08 7.2256542025082515 -1.0007349837365653 down DLEDLFYK(ub)YGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLEDLFYKYGR 11 1 Q13242;H0YIB4;S4R3G0 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 21692300.0 9496300.0 9893400.0 2302600.0 True False 7896594.207420583 9840102.290513864 2784063.0139804967 1.0 1.2461197868401201 0.35256503510896614 22.912799123941728 -6.833254903356709 1.3132388077283126 1.1312437178813435 0.32686981314394453 0.9122428426025198 0.11163933211554927 0.17682618705088785 0.5952391909187803 0.06672229487811378 0.15355558293498092 1.468064363916132e-07 6.833254903356709 -0.804373904737399 down DLEEDHACIPIK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLEEDHACIPIKK 13 1 P13639 P13639 EEF2 Elongation factor 2 1 27090500.0 7652700.0 9874400.0 9563400.0 True False 10032763.808852222 8401178.010109741 8573871.106610479 1.0 0.837374244044011 0.8545871576330227 23.258215756110054 -10.799895316865506 7.027444403934245 1.006044363953219 0.8459807008385273 0.9907195130419874 0.007027142546616256 0.0006850820936090943 1.9507510094069033e-05 0.007004519964169854 0.0022680005045391917 1.5852752640543813e-11 10.799895316865506 -0.16006366311469178 DLEEDHACIPIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLEEDHACIPIKK 13 1 P13639 P13639 EEF2 Elongation factor 2 1 6899200.0 2942200.0 1525500.0 2431500.0 True False 2848801.471478857 2134640.105377406 1794617.2065635745 1.0 0.749311640965027 0.6299551669467374 21.441923655326885 -13.999999999148468 0.09847678420228108 2.2437657201713592 0.3696271387584079 0.9998013232194689 0.0021736109113138532 12.092210830403713 0.0931432419589339 3.0686142137441608 0.23238988161180832 1.0000000019607253e-14 13.999999999148468 -1.8741385814129514 DLEEDHACIPIK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLEEDHACIPIKK 13 1 P13639 P13639 EEF2 Elongation factor 2 1 143740000.0 15498000.0 36709000.0 91533000.0 True False 23511599.05556674 30157992.14127387 73441462.42966087 1.0 1.282685710572012 3.1236268641741938 24.48686932617504 -6.934127469946729 0.7121056895248946 0.9758310158403873 3.544604988413695 0.9972889595893405 0.04902466315965295 0.0905507189570746 0.06759349062287151 0.04581592722457486 0.16295892351254093 1.1637843964538122e-07 6.934127469946729 2.5687739725733074 up DLEEDHACIPIK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLEEDHACIPIKK 13 1 P13639 P13639 EEF2 Elongation factor 2 1 26835000.0 7652700.0 7697300.0 11485000.0 True False 10482109.996441415 7357207.834432772 8772479.540999793 1.0 0.7018823344661028 0.8369001607479766 23.321425817632946 -10.099775980973504 4.53133649655235 1.000019187669349 0.7693912476038867 0.7954854689530226 0.05512079679050113 76735974.39116228 0.3062387445921969 15385.056890286194 0.018869314864342106 7.947380730877116e-11 10.099775980973504 -0.23062794006546228 DLEEDHACIPIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLEEDHACIPIKK 13 1 P13639 P13639 EEF2 Elongation factor 2 1 11994300.0 2942200.0 1209500.0 7842600.0 True False 2446569.6615600656 1202984.183433048 9482451.399914647 1.0 0.491702403710001 3.875815002900069 21.22232893076116 -6.86865489918098 1.1412520835880229 0.7147618111378808 4.068949745656335 0.9633188098247032 0.28536975287057686 0.138147671455486 0.33713934364931325 0.19421976231627494 0.45875844848339004 1.353147379485557e-07 6.86865489918098 3.354187934518454 up DLEEDHACIPIK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLEEDHACIPIKK 13 1 P13639 P13639 EEF2 Elongation factor 2 1 129666000.0 15498000.0 27250000.0 86918000.0 True False 20062466.511252023 25733513.54532482 71099815.85399272 1.0 1.2826694828819873 3.543921970616944 24.25799564826749 -6.930096475519982 0.7459990271809638 0.9657363942334616 4.00928926073212 0.9965571978684608 0.06679925727590873 0.09258770434987411 0.07743472227749583 0.06089235703632428 0.2044958036477676 1.1746365885483799e-07 6.930096475519982 3.0435528664986586 up DLEEDHACIPIKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLEEDHACIPIKK 13 1 P13639 P13639 EEF2 Elongation factor 2 0 10968600.0 5552700.0 1477000.0 3938900.0 False True 5376432.577894315 2066773.8024532476 2907183.925532908 1.0 0.384413600005136 0.5407273100542646 22.358217788705016 -10.413912404986595 9.06329873867064 1.0000026208042128 0.46257045503024136 0.9403381922015199 0.0638148049036207 3.3794208363833984e-06 2.185171586394662e-07 0.0617887200486309 0.0205961397194332 3.855561145536842e-11 10.413912404986595 -0.5374321657739713 DLEEFFSTVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLEEFFSTVGK 11 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;Q5QP23;Q5QP22 Q14498-3 RBM39 RNA-binding protein 39 0 5102500.0 0.0 2819300.0 2283200.0 False True 0.0 2398671.429545327 2046956.3660009014 0.0 DLEEFFSTVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLEEFFSTVGK 11 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;Q5QP23;Q5QP22 Q14498-3 RBM39 RNA-binding protein 39 0 5559800.0 0.0 3193900.0 2365900.0 False True 0.0 3052782.937185093 1807123.147240002 0.0 DLEGENIEIVFAKPPDQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLEGENIEIVFAKPPDQKR 19 2 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 10347100.0 4087000.0 3900800.0 2359300.0 True False 3957260.4221106987 5458409.782403266 1741328.5525171459 1.0 1.3793405538602117 0.440033853417301 21.91607057962465 -6.797120007854364 1.4680215957170584 1.2100700421634443 0.42802515978172323 0.8234961227545088 0.16209481286217828 0.22489885164643983 0.9572020583847055 0.08688440019234574 0.20239201632073797 1.5954382215934776e-07 6.797120007854364 -0.782044882381721 down DLEHLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLEHLSK 7 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 9242210.0 2580700.0 909710.0 5751800.0 False True 2498777.0911037596 1272961.9470749781 4245231.02969869 1.0 0.5094339753662003 1.6989234633264094 21.252790777710455 -6.794707491645554 1.4774369591202086 0.7274936588609909 1.7132741911440448 0.8162355677188371 0.20923066508919066 0.22839898070046802 0.9847242760526542 0.11144084518794162 0.2600485863444406 1.6043255808723796e-07 6.794707491645554 0.9857805322830538 DLEK(ub)WQNNLLPSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLEKWQNNLLPSR 13 1 P62244;I3L3P7;H3BVC7 P62244 RPS15A 40S ribosomal protein S15a 1 45835000.0 13090000.0 14726000.0 18019000.0 True False 12674465.115103751 20606168.595075484 13299283.34158712 1.0 1.625801831315136 1.0492974039384741 23.595421528436596 -10.3731340661246 4.976053930088179 0.9997435404201868 1.3375496176268669 0.3137040468841932 0.23535694692158465 0.0006701297705031775 8.442015069547523e-05 0.22805452780503624 0.07596112798676269 4.235122082170347e-11 10.3731340661246 0.3378060772066801 DLEK(ub)WQNNLLPSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLEKWQNNLLPSR 13 1 P62244;I3L3P7;H3BVC7 P62244 RPS15A 40S ribosomal protein S15a 1 92769000.0 19046000.0 34894000.0 38829000.0 True False 28894174.449111138 28666893.07193362 31154431.13064475 1.0 0.9921340068885578 1.0782253421192016 24.78427531470343 -6.884567181978336 1.0539529379654373 0.9947540420024422 1.084888353019931 0.9771883620750115 0.005869636062567885 0.12366339159127691 0.2484667637181908 0.004270714125927774 0.010459001409901384 1.3044661622624108e-07 6.884567181978336 0.0901343110174887 DLEK(ub)WQNNLLPSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLEKWQNNLLPSR 13 1 P62244;I3L3P7;H3BVC7 P62244 RPS15A 40S ribosomal protein S15a 1 39177000.0 13090000.0 15865000.0 10222000.0 True False 10884914.985324342 15779532.096044047 12359372.93881207 1.0 1.4496697601514485 1.1354588396396 23.375826803870872 -10.233465815005225 8.803680964796541 0.9999999477828786 1.2925642998955242 0.5361672345758626 0.12827607114403897 1.314810685165667e-07 1.135222570893709e-08 0.1242027940234954 0.041400923938148385 5.841631870221321e-11 10.233465815005225 0.29256435211264564 DLEK(ub)WQNNLLPSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLEKWQNNLLPSR 13 1 P62244;I3L3P7;H3BVC7 P62244 RPS15A 40S ribosomal protein S15a 1 164201000.0 19046000.0 42795000.0 102360000.0 True False 24655422.45278786 40413420.630171604 83731530.302293 1.0 1.6391291087207447 3.3960695852049874 24.555401636795878 -6.9533969822332615 0.5202148527402748 0.9701944880596926 4.143439331315493 0.9994416127883506 0.023938647031935295 0.08214967533705074 0.0305338777265128 0.02711015905221012 0.14512731886632052 1.1132764386416667e-07 6.9533969822332615 3.1732448432558007 DLEKPFLLPVEAVYSVPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLEKPFLLPVEAVYSVPGR 19 1 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 24261300.0 1957400.0 15307000.0 6996900.0 False True 2566170.355488566 13023255.266218672 6272927.907004091 1.0 5.074976896356208 2.4444705682097263 21.291185516392687 -9.51136214591047 8.974374508640286 0.9999999854292736 3.7597237322829757 0.5947388029063188 1.0738997115202056 0.0 0.0 1.0397989245536625 0.34659964151788747 3.0806180384781774e-10 9.51136214591047 2.759723746853702 DLEKPFLLPVEAVYSVPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLEKPFLLPVEAVYSVPGR 19 1 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 29465400.0 10817000.0 5249400.0 13399000.0 False True 10473620.255926456 7345512.795259364 9889399.938616224 1.0 0.7013346498888896 0.9442198301031915 23.320256866986803 -9.960743169105028 6.199649664968418 1.0000000638985131 0.8227772406978004 0.4151584671286396 0.0991574596015466 8.754138635879064e-08 1.476876828080868e-08 0.09600883175758439 0.03200293247407796 1.0946034960367786e-10 9.960743169105028 -0.1772228232007127 DLEKPFLLPVEAVYSVPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLEKPFLLPVEAVYSVPGR 19 1 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 30545400.0 1957400.0 13220000.0 15368000.0 False True 2681103.6767460424 12635896.68730609 11738394.913895074 1.0 4.712945939726514 4.378195075298817 21.35439557791558 -10.192031949763967 4.7336392565375895 0.9994690460630656 4.545570507530393 0.9933589213592733 0.13666146819477548 0.0007658608982251335 0.00013072238620383505 0.132337151532045 0.04410729919025569 6.426404384165402e-11 10.192031949763967 3.5461014614673276 DLEKPFLLPVEAVYSVPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLEKPFLLPVEAVYSVPGR 19 1 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 15622100.0 10817000.0 2046600.0 2758500.0 False True 8994814.774350911 2035574.5595817077 3335289.5961370645 1.0 0.22630533375586936 0.3708013649872793 23.10066214242108 -9.9231341529774 6.719041782817802 1.0000000407837524 0.2985533494882448 0.9691555314100265 0.05899025772907037 3.602355105744078e-08 5.826886876833907e-09 0.0571170748476975 0.019039023814426008 1.193619340113868e-10 9.9231341529774 -0.7014466912955075 DLENLK(ub)AEVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLENLKAEVAR 11 1 I3L2B0;A0A494C0R8;K7EIG1;O75153 I3L2B0 CLUH Clustered mitochondria protein homolog 1 5440200.0 1545000.0 2386500.0 1508700.0 True False 2025509.9618012847 2030443.5025041413 1352594.1964723023 1.0 1.0024357030061057 0.6677795824165886 20.949853749784697 -6.905258555974747 0.9274074388480912 1.0119784634148452 0.6286438414722768 0.9890062209795355 0.016481295696842407 0.10763791598583189 0.15638762670806491 0.013184799357868386 0.035305057828633975 1.2437739140730981e-07 6.905258555974747 -0.3833346219425684 DLENLK(ub)AEVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLENLKAEVAR 11 1 I3L2B0;A0A494C0R8;K7EIG1;O75153 I3L2B0 CLUH Clustered mitochondria protein homolog 1 6672900.0 2165400.0 2416800.0 2090700.0 True False 2096660.5622800356 3381840.843445507 1543082.9503444228 1.0 1.6129653527549965 0.7359717534183888 20.99966188533502 -6.718777346282029 1.7635338222513806 1.3733995813104116 0.7374132083820442 0.5068409292842294 0.25797694115418196 0.357688730716935 2.1733502175842565 0.11617722674488287 0.29208849197975284 1.9108326515126063e-07 6.718777346282029 -0.6359863729283675 DLENLK(ub)AEVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLENLKAEVAR 11 1 I3L2B0;A0A494C0R8;K7EIG1;O75153 I3L2B0 CLUH Clustered mitochondria protein homolog 1 5877400.0 1545000.0 2029000.0 2303400.0 True False 2116228.252055091 1939352.0709942554 1759384.360012096 1.0 0.9164191382054042 0.8313774085113644 21.01306381130759 -6.97090947744724 0.23545960038554742 1.032308254637326 0.7130422984516193 0.9999886245487624 0.00023211092128318909 0.07600870266664526 0.007966802169310623 0.0020998443771317833 0.00835933256279121 1.0692777318422157e-07 6.97090947744724 -0.31926595618570663 DLENLK(ub)AEVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLENLKAEVAR 11 1 I3L2B0;A0A494C0R8;K7EIG1;O75153 I3L2B0 CLUH Clustered mitochondria protein homolog 1 7061400.0 2165400.0 3343200.0 1552800.0 True False 1800626.0434852047 3325189.518026755 1877483.300663995 1.0 1.84668522931651 1.0426836307610152 20.780067160769295 -10.376164607890559 4.206206599286667 0.9989430088971298 1.4446844300442605 0.28971046111606125 0.3282322781589171 0.0032608408932295577 0.00048362558497870166 0.3185309369741917 0.1059365122472166 4.205671932483423e-11 10.376164607890559 0.44574142114713067 DLENLK(ub)AEVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLENLKAEVAR 11 1 I3L2B0;A0A494C0R8;K7EIG1;O75153 I3L2B0 CLUH Clustered mitochondria protein homolog 1 17811400.0 6576200.0 7407400.0 3827800.0 True False 8513020.53628182 6995171.678372087 3131179.6765447194 1.0 0.8217026669393335 0.3678106570047469 23.021239680029193 -6.955072159146035 0.5000701870762031 1.0090845146010392 0.16084971391361588 0.9995415521642523 0.005698411280737065 0.08151069411979922 0.02801114010383033 0.006681883759967119 0.037442073178472556 1.1089905383213147e-07 6.955072159146035 -0.8482348006874233 down DLESLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLESLR 6 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 7847300.0 2281900.0 641700.0 4923700.0 False True 2209462.333548911 897934.156421292 3634035.262166186 1.0 0.40640392134633074 1.6447599974827718 21.07526390586585 -6.776357089994672 1.5500502905226883 0.6623025543074332 1.6534751896681847 0.7543009648030549 0.2506658449383832 0.2562717166075727 1.2159062877549087 0.127404211658275 0.301550505817621 1.673566253608101e-07 6.776357089994672 0.9911726353607515 DLFGK(ub)FGPALSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLFGKFGPALSVK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAP2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 17054000.0 6682800.0 6407800.0 3963400.0 True False 8761215.51632726 5451781.217408771 3553305.3876173724 1.0 0.6222631103240092 0.40557219269352407 23.062699610123765 -9.566851511559328 0.13421538800116758 1.641715308958439 1.0284845516997668e-12 0.9998495299402994 0.003012983288044576 1.0259098702987077 0.05414550194822781 0.44785256081946884 0.20485942022629205 2.711118424542351e-10 9.566851511559328 -1.6417153089574106 DLFGK(ub)FGPALSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLFGKFGPALSVK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAP2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 25890400.0 11853800.0 9520500.0 4516100.0 True False 11477507.607442072 13322085.298751622 3333197.9299040763 1.0 1.1607123910868522 0.2904113021665797 23.452306052499264 -6.859028180758818 1.1906909643928196 1.086976574009997 0.24905376069286345 0.952443260468044 0.08245841903092122 0.14780523732800646 0.3987474047566479 0.054035852698368275 0.1259965108813389 1.3834766042058444e-07 6.859028180758818 -0.8379228133171336 down DLFGK(ub)FGPALSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLFGKFGPALSVK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAP2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 52781500.0 14498200.0 14089900.0 24193400.0 True False 21994829.360396042 11575447.260108829 19411563.88565609 1.0 0.5262803848322467 0.882551238183671 24.390661072831005 -9.748391043375646 5.997547777256375 1.000000009206545 0.7044158115068522 0.4785648800106158 0.1454469668267611 53663619.02865191 87224627.35831855 4.426797241313539 0.04979037056152677 1.7848797263886363e-10 9.748391043375646 -0.2955841976996929 DLFGK(ub)FGPALSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLFGKFGPALSVK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAP2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 15601000.0 6682800.0 5705900.0 3212300.0 True False 9153611.75587945 5453794.471111947 2453620.8993951776 1.0 0.5958079298708429 0.26804948307089754 23.125909671646657 -7.805821187592271 0.27211670769451757 1.134333294718986 5.578656178755328e-14 0.9995969398425036 0.006010058425599428 0.12004260805767687 0.04182033154252874 0.04593716075243575 0.08463101429314596 1.5637913711584438e-08 7.805821187592271 -1.1343332947189302 down DLFGK(ub)FGPALSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLFGKFGPALSVK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAP2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 26794600.0 11853800.0 11178400.0 3762400.0 True False 9856959.912378728 11118179.740461316 4549100.444627908 1.0 1.1279522123752073 0.4615115091332554 23.23271132793354 -6.856967674729143 1.2010120803844404 1.0689353922255456 0.4310675162728603 0.9498379070021274 0.06467516247540142 0.14996225557168053 0.41277655094769616 0.042049909520050756 0.09784276443784783 1.3900560915825874e-07 6.856967674729143 -0.6378678759526852 down DLFGK(ub)FGPALSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLFGKFGPALSVK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAP2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 49638000.0 14498200.0 16843800.0 18296000.0 True False 18768205.702247657 15906427.723109823 14966315.732813148 1.0 0.8475198948402878 0.7974292252679648 24.161787394923454 -13.999999999991063 0.1556160829037661 1.7444087871818423 0.7457256136354543 0.9995485860271219 0.0018303468001619827 11.98329485655561 0.12449913117806082 2.6939138418091644 0.04687752682480665 1.0000000000205779e-14 13.999999999991063 -0.998683173546388 DLFGK(ub)SDPYLEFHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLFGKSDPYLEFHK 14 1 O75131;A0A087WYQ3 O75131 CPNE3 Copine-3 1 52451700.0 19489000.0 23179000.0 9783700.0 True False 25550267.731744453 19720783.55103434 8771376.575877288 1.0 0.771842540285111 0.3432988126766067 24.606835072917928 -6.961254034646418 0.41738403889836423 1.0194843830124347 0.0795603594170569 0.999813918322826 0.0037134755816617066 0.07925615637133065 0.01949831452472333 0.0055350276578765185 0.035699394893685114 1.0933166584968672e-07 6.961254034646418 -0.9399240235953779 down DLFGK(ub)SDPYLEFHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLFGKSDPYLEFHK 14 1 O75131;A0A087WYQ3 O75131 CPNE3 Copine-3 1 87729000.0 39705000.0 26609000.0 21415000.0 True False 38444586.50841818 37234112.46410188 15805769.063770903 1.0 0.9685137972793324 0.4111312020564957 25.19627712670791 -6.918530558070798 0.8355555819952897 1.0129618446565134 0.32421839918417567 0.9937628021547128 0.021361382174765645 0.09904428135231942 0.11015247611441506 0.018263181839495827 0.0539612870149841 1.2063392040981388e-07 6.918530558070798 -0.6887434454723378 down DLFGK(ub)SDPYLEFHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLFGKSDPYLEFHK 14 1 O75131;A0A087WYQ3 O75131 CPNE3 Copine-3 1 191898000.0 62268000.0 44792000.0 84838000.0 True False 94465108.40056968 36798517.63850667 68069732.1141837 1.0 0.3895461325515692 0.7205806807053131 26.493278218595787 -10.627148493894621 6.7297620563846285 1.0013775145883819 0.555063406628496 0.7066357155767189 0.13514428836824327 0.0028005268429083237 0.0001551583115040745 0.13119811948858312 0.04361763151543824 2.3596712768337727e-11 10.627148493894621 -0.4463141079598859 DLFGK(ub)SDPYLEFHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLFGKSDPYLEFHK 14 1 O75131;A0A087WYQ3 O75131 CPNE3 Copine-3 1 61088000.0 19489000.0 26976000.0 14623000.0 True False 26694609.970421758 25784111.12229721 11169348.57013843 1.0 0.9658920340423253 0.4184121282354125 24.67004513444082 -6.919620074854433 0.8275432226686062 1.0122461658105528 0.3308940597043623 0.994074614686325 0.020513309059373982 0.09839598925338539 0.10677778491753427 0.017638806836763662 0.05264595210845062 1.2033166477155249e-07 6.919620074854433 -0.6813521061061905 down DLFGK(ub)SDPYLEFHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLFGKSDPYLEFHK 14 1 O75131;A0A087WYQ3 O75131 CPNE3 Copine-3 1 83620000.0 39705000.0 25573000.0 18342000.0 True False 33016466.729740456 25435233.173156943 22177227.39617405 1.0 0.7703802281861216 0.6717020200164946 24.976682402142185 -13.999999999999872 0.1152128383697121 2.0994776827186405 0.5035450713620342 0.9997167163117002 0.0023148442748049743 11.98459346748087 0.10381371594875685 3.0379495611622978 0.14922752746355356 1.0000000000002946e-14 13.999999999999872 -1.5959326113566064 DLFGK(ub)SDPYLEFHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLFGKSDPYLEFHK 14 1 O75131;A0A087WYQ3 O75131 CPNE3 Copine-3 1 187915000.0 62268000.0 44427000.0 81220000.0 True False 80607153.4857814 41954598.3955283 66438793.38757555 1.0 0.5204823217449159 0.8242294947097337 26.264404540688236 -10.655826870933927 5.113971837154082 1.0056925997633743 0.6723559082273394 0.6080556546985029 0.12400426409612175 0.00815153253940992 0.0005486021259485914 0.12160577721518004 0.040022204141914965 2.2088851172241535e-11 10.655826870933927 -0.33333669153603496 DLFPYEESKEK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLFPYEESKEK 11 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 15741900.0 3075900.0 5786000.0 6880000.0 True False 4666365.17841127 4753443.093775664 5520164.984388874 1.0 1.0186607588637204 1.1829689219197141 22.153867782875988 -6.928356187156944 0.7601545432971589 0.9973431500695471 1.2153316719278595 0.9962054090145587 0.005064014601941786 0.09350012837394552 0.08192502946024084 0.0045692569770979475 0.015003648779857753 1.1793529910829722e-07 6.928356187156944 0.2179885218583124 DLFPYEESKEK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLFPYEESKEK 11 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 5306300.0 1958300.0 1507600.0 1840400.0 True False 1628413.2173995886 1499478.2595648284 2225219.1309518414 1.0 0.9208217199067836 1.366495375482945 20.635035405936506 -6.860982077928006 1.180644949303227 0.9569190728008715 1.3884975557872519 0.9548305200720765 0.041260793281745985 0.14580004904821042 0.3856081495065177 0.02724481949192469 0.0636745400012836 1.3772663035017394e-07 6.860982077928006 0.43157848298638035 DLFPYEESKEK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLFPYEESKEK 11 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 17786600.0 3075900.0 6183800.0 8526900.0 True False 3981813.185053568 5839666.094002928 6975091.693382395 1.0 1.4665846494062393 1.7517375550326224 21.924994104968437 -9.353616476065188 0.1081287261565628 1.072445942718945e-20 2.5079387172664718 0.9999364735894072 0.002469689986692476 0.8148255289896194 0.04085156623762835 0.5823189277372872 0.3428712781581083 4.4297939323220207e-10 9.353616476065188 2.5079387172664718 DLGLPTEAYISVEEVHDDGTPTSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLGLPTEAYISVEEVHDDGTPTSK 24 0 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 61008000.0 10769000.0 31621000.0 18618000.0 False True 16337360.319357218 25977985.493999336 14938144.139440713 1.0 1.5900968691508557 0.9143548191038762 23.961671565576875 -6.675969403809758 1.9166314959064592 1.3747098252549337 0.917026228561499 0.3056354570294785 0.2503212877662991 0.447513235882911 3.1748770157838937 0.1049455878338619 0.278181372916125 2.1087767087185203e-07 6.675969403809758 -0.4576835966934347 DLGLPTEAYISVEEVHDDGTPTSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLGLPTEAYISVEEVHDDGTPTSK 24 0 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 34045500.0 10769000.0 14567000.0 8709500.0 False True 13940682.788725834 13756333.644577868 7124460.367016611 1.0 0.9867761753895545 0.5110553388947586 23.732797887669324 -6.912851616481751 0.8760790616918194 1.0134344471462027 0.44567101869498754 0.9919541455241927 0.020400881984809056 0.10256281051489835 0.12875808323509735 0.01694160626748232 0.04774495772618544 1.2222171784949038e-07 6.912851616481751 -0.5677634284512152 DLGLSESGEDVNAAILDESGKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLGLSESGEDVNAAILDESGKK 22 1 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 38180800.0 10898000.0 5637800.0 21645000.0 False True 10552048.955263607 7889002.940738613 15975525.163918803 1.0 0.747627591019031 1.5139737535002469 23.33101982718052 -6.817964155726645 1.380559135146015 0.8636825591023083 1.5299979482675035 0.8796533249111456 0.11062194560623001 0.19614373130922336 0.7351014699974812 0.06297398438188355 0.14523669489808355 1.520673032525701e-07 6.817964155726645 0.6663153891651952 DLGTPSEK(ub)IWPGYSELPAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLGTPSEKIWPGYSELPAVK 20 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12 P21127 CDK11B Cyclin-dependent kinase 11B 1 7465200.0 1777200.0 3059300.0 2628700.0 True False 2329926.4104292816 2602864.365058002 2356707.3402709235 1.0 1.1171444528921548 1.011494324336496 21.1518529581156 -10.794331993335026 3.3894389213205267 0.9870805876178421 1.0643193886177056 0.3307352246721611 0.04313148438078981 0.005013315309363 0.0003042031523242739 0.04972085376551579 0.013920626723944207 1.6057133075814215e-11 10.794331993335026 0.07723880099986347 DLGTPSEK(ub)IWPGYSELPAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLGTPSEKIWPGYSELPAVK 20 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12 P21127 CDK11B Cyclin-dependent kinase 11B 1 45360400.0 5454400.0 11598000.0 28308000.0 True False 8274723.57005312 9528246.284412393 22712911.392162833 1.0 1.1514881680030824 2.7448543990475596 22.980279686588467 -6.925384575241266 0.7837481687787773 0.9711835582127689 3.0365746521789747 0.9955508410013826 0.05264476065498629 0.09510600861692751 0.08994595059906461 0.046704845331251445 0.1479988811147442 1.1874502540903751e-07 6.925384575241266 2.065391093966206 up DLGTPSEK(ub)IWPGYSELPAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLGTPSEKIWPGYSELPAVK 20 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12 P21127 CDK11B Cyclin-dependent kinase 11B 1 97515200.0 5454400.0 8551800.0 83509000.0 True False 7060828.322297913 8075884.812363627 68311218.87469894 1.0 1.1437588401434704 9.674674946985169 22.751406008680917 -6.910556842584487 0.891914414865538 0.7404934161183958 10.790459711898876 0.9911304499765085 0.38197031346110993 0.10405149939676375 0.13677113295619492 0.31358746033521995 0.8690420134964081 1.228692358792389e-07 6.910556842584487 10.04996629578048 up DLGVFIPAPMAQGMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLGVFIPAPMAQGMR 15 0 D3DQV9;P78344;H0Y3P2;P78344-2;H0YCH5 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 1763040.0 481830.0 708730.0 572480.0 False True 631683.7960483577 602990.246607902 513245.2612159243 1.0 0.9545760875616016 0.8125034462283934 19.268843039119098 -6.950510146371762 0.5532182599914162 1.0019283732949564 0.7584398894198693 0.9992406828274045 0.002200674817497705 0.08328160884001212 0.03512009454304304 0.002378804203510999 0.011793455464218531 1.1207012430172408e-07 6.950510146371762 -0.24348848387508715 DLGVFIPAPMAQGMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLGVFIPAPMAQGMR 15 0 D3DQV9;P78344;H0Y3P2;P78344-2;H0YCH5 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 1846930.0 481830.0 539330.0 825770.0 False True 659975.5719661516 515500.6172741912 630740.1332669923 1.0 0.7810904511790473 0.9557022412025596 19.33205310064199 -10.08775555093435 5.470671211436037 1.0000013448643557 0.8683963461907456 0.4309788217425511 0.07128496477213753 1.1692964504072731e-06 1.9505633130390082e-07 0.06902207537134206 0.023007123449759758 8.170421261887194e-11 10.08775555093435 -0.13160499867361009 DLGYGK(ub)GYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLGYGKGYK 9 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 28916000.0 11797000.0 8487800.0 8631200.0 True False 15465981.24231049 7221453.325185263 7738126.220316664 1.0 0.4669250021737668 0.500332057764778 23.882595032621367 -9.95665927885615 5.423289502833342 1.0000011340271344 0.48362852996780425 0.9968706648454978 0.01363837333961808 37435014.00864561 14.44873464400957 530.1129206445794 0.004668777952823391 1.1049451529797934e-10 9.95665927885615 -0.5163726040593302 DLGYGK(ub)GYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLGYGKGYK 9 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 50686000.0 14438000.0 19929000.0 16319000.0 True False 13979673.592961635 27886753.628362037 12044564.340493923 1.0 1.9948072065432356 0.8615769359992794 23.736827340281607 -6.674854198149918 1.920390601086591 1.6323130904633523 0.8660671440667225 0.30067662187429267 0.422105531207284 0.45003585313289945 3.2042361309708753 0.17667501590717097 0.4690252446734994 2.114198701960183e-07 6.674854198149918 -0.7662459463966298 DLGYGK(ub)GYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLGYGKGYK 9 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 52982000.0 16405000.0 16419000.0 20158000.0 True False 24887584.366148703 13488901.167767469 16173762.464434722 1.0 0.5419931870171635 0.6498727327845348 24.568922870741666 -9.861647852852759 6.511772014475473 1.0000000156229758 0.5959329599008316 0.9492525295167141 0.04404164013567179 9.987377877233179e-09 1.7564774895799609e-09 0.04264313660251854 0.014214378232074746 1.375156567082063e-10 9.861647852852759 -0.4040670557221442 DLGYGK(ub)GYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLGYGKGYK 9 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 29589400.0 11797000.0 9616200.0 8176200.0 True False 16158669.701937774 9191324.48747904 6245149.954124731 1.0 0.5688169049198897 0.3864891150894558 23.94580509414426 -13.999999999993616 0.11775876834141802 3.058970893841826 0.08649674477538975 0.9997040065283488 0.004425694516960897 11.97293008688422 0.1053149196574523 5.787047882195606 0.2661921236843022 1.0000000000147003e-14 13.999999999993616 -2.972474149066436 DLGYGK(ub)GYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLGYGKGYK 9 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 59104000.0 14438000.0 32590000.0 12076000.0 True False 12005836.71184971 32414431.201391477 14601035.766884629 1.0 2.6998893937478403 1.216161448578879 23.517232615715884 -6.61335937850975 2.1424601976470528 2.1331726925233556 1.2217195038535789 0.060707804360212614 0.7322639082350787 0.6033150025838905 5.253129151640241 0.28184964903078485 0.8120107106678449 2.435794365315514e-07 6.61335937850975 -0.9114531886697768 DLGYGK(ub)GYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLGYGKGYK 9 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 63272000.0 16405000.0 23389000.0 23478000.0 True False 21236595.89089493 22087381.589416612 19205244.904623266 1.0 1.0400622445750098 0.904346676053548 24.340049192834115 -6.827643383327391 1.338438385440133 1.0214435917474645 0.9008680139804012 0.9010785372285218 0.017906736850459556 0.18373257055092573 0.6445450946745463 0.010507133794986145 0.0241830349524531 1.4871563049274278e-07 6.827643383327391 -0.12057557776706329 DLGYIYFYQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLGYIYFYQR 10 0 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 20417700.0 4742200.0 8015300.0 7660200.0 False True 6217070.123530129 6819448.483394687 6867595.985826966 1.0 1.09689103514929 1.1046354391009283 22.567803420726253 -13.705612437635155 0.36092854474096236 5.125481496962313e-07 1.1055666194425258 0.9997667216927619 0.0007270750565923065 17.540272680956836 0.1936920104411568 13.394148336132846 0.0022288963409865647 1.969643206045107e-14 13.705612437635155 1.105566106894376 DLGYIYFYQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLGYIYFYQR 10 0 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 32678100.0 14167000.0 5393100.0 13118000.0 False True 13717276.339623736 7546592.9546449585 9682002.268435534 1.0 0.5501524331653117 0.7058254152442853 23.709490717048936 -10.220705765501425 6.405714403522835 1.0000037898285898 0.6279889242047983 0.8839125393875171 0.06355322880515347 3.439767661917443e-06 4.1842099360676534e-07 0.06153577618976835 0.02051171639667228 6.015811706749497e-11 10.220705765501425 -0.3720148656237915 DLGYIYFYQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLGYIYFYQR 10 0 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 67029000.0 19127000.0 22442000.0 25460000.0 False True 29017057.37100436 18437049.759853672 20427819.84048556 1.0 0.6353866115410143 0.7039935021425813 24.790397886872178 -10.761395960699003 6.991665514778313 1.007090583789645 0.6696900568419699 0.9686581940528982 0.028008645802130996 0.0031214933556954014 0.00010652680688849893 0.027345352764911415 0.009039751561789638 1.732223951481778e-11 10.761395960699003 -0.3374005269476752 DLGYIYFYQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLGYIYFYQR 10 0 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 18939000.0 4742200.0 4510500.0 9686300.0 False True 6495519.493136343 4311211.19577112 7398595.4356104685 1.0 0.6637207694206247 1.1390305953863096 22.631013482249145 -6.716640813181006 1.771388140968933 0.7946814566070749 1.1381543482080811 0.49662459857978203 0.14156892527429624 0.36188611243632424 2.217321840126731 0.06350305188748401 0.16005058802667743 1.9202562478040712e-07 6.716640813181006 0.34347289160100625 DLGYIYFYQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLGYIYFYQR 10 0 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 24974400.0 14167000.0 4213300.0 6594100.0 False True 11780488.20451412 4190602.1166254347 7972895.82232641 1.0 0.3557239771285246 0.6767882352508368 23.489895992483213 -10.56782232769318 6.509259358220642 1.0007438047340889 0.5162561061898101 0.7516647462502881 0.1310739345074824 0.00141684314599766 9.407036636077284e-05 0.1270910829983038 0.04230393045578009 2.7050647949397076e-11 10.56782232769318 -0.48448769854427876 DLGYIYFYQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLGYIYFYQR 10 0 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 76175000.0 19127000.0 31119000.0 25929000.0 False True 24760278.54953658 29387200.29420051 21210188.054007005 1.0 1.1868687274824916 0.8566215445263633 24.561524208964627 -6.7531839460112115 1.637898350727919 1.1094591465337857 0.8557963030955542 0.6625991185162902 0.07853952374563695 0.2945359574763618 1.5555250589243679 0.03786316036751534 0.09162225448169381 1.7652899713823074e-07 6.7531839460112115 -0.25366284343823153 DLHGQAESAAAVWK(ub)GHVMDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLHGQAESAAAVWKGHVMDR 20 1 A0A1X7SBW3;Q5TA31 A0A1X7SBW3 RNF187 E3 ubiquitin-protein ligase RNF187 1 18524900.0 1489400.0 3265500.0 13770000.0 True False 1952617.8233701165 2778300.1288193045 12345212.491166983 1.0 1.422859146099621 6.3223905586705085 20.89697817431789 -6.923904884913376 0.7952211323398461 0.906339941233679 7.188114704470783 0.9951988517071977 0.16737123839648302 0.0959282369900099 0.09410261121810455 0.14727482610596912 0.45907210921447666 1.1915029312025891e-07 6.923904884913376 6.281774763237104 up DLIETK(ub)AEEHNIVFMPVIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLIETKAEEHNIVFMPVIGK 20 1 Q9UBB9;Q9UBB9-2 Q9UBB9 TFIP11 Tuftelin-interacting protein 11 1 19943800.0 5955300.0 10825000.0 3163500.0 True False 7807455.9712072415 9209952.195519501 2836171.3664347683 1.0 1.1796354957984343 0.36326447140965695 22.896421097764698 -6.84902093986468 1.2398126708816535 1.0957855899117948 0.33124167691515444 0.9388672246268547 0.08660288016582603 0.1585379571332917 0.46944440792232994 0.054672489299055 0.12643837539171046 1.4157255179443284e-07 6.84902093986468 -0.7645439129966403 down DLIETK(ub)AEEHNIVFMPVIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLIETKAEEHNIVFMPVIGK 20 1 Q9UBB9;Q9UBB9-2 Q9UBB9 TFIP11 Tuftelin-interacting protein 11 1 51221000.0 21291000.0 16141000.0 13789000.0 True False 20615128.859104175 22586185.47420302 10177247.23886702 1.0 1.0956121413826805 0.49367856531114934 24.297200143327863 -6.866245961189862 1.153690624763345 1.0530280614577296 0.4608412850460558 0.960795019576052 0.052296111119247715 0.14050947916116602 0.35188382288952863 0.03525200496740714 0.08296296707565687 1.3606738512402507e-07 6.866245961189862 -0.5921867764116738 down DLIETK(ub)AEEHNIVFMPVIGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLIETKAEEHNIVFMPVIGK 20 1 Q9UBB9;Q9UBB9-2 Q9UBB9 TFIP11 Tuftelin-interacting protein 11 1 74153000.0 24006000.0 18586000.0 31561000.0 True False 36418857.073682755 15269183.086919183 25322954.51632232 1.0 0.41926585054622995 0.6953253493125506 25.11818231140264 -10.457860922182455 6.187914137246642 1.0001956157299239 0.5572955999294036 0.7742127971451487 0.11270081843766142 0.00030427443675601915 2.6658222102686985e-05 0.10916946246260353 0.03637403274275068 3.484488839219365e-11 10.457860922182455 -0.4429000158005203 DLIETK(ub)AEEHNIVFMPVIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLIETKAEEHNIVFMPVIGK 20 1 Q9UBB9;Q9UBB9-2 Q9UBB9 TFIP11 Tuftelin-interacting protein 11 1 51043800.0 21291000.0 23395000.0 6357800.0 True False 17704409.851225384 23268966.4914561 7687186.584854178 1.0 1.3143034242310863 0.4341961494029761 24.07760541876214 -6.810147365381221 1.4139788117027792 1.1712610606215512 0.41875622616595587 0.8601990040759897 0.13615914308106886 0.2065980353496833 0.8140869954533707 0.07571792765758383 0.17513413892799426 1.5482911615518773e-07 6.810147365381221 -0.7525048344555954 down DLIETK(ub)AEEHNIVFMPVIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLIETKAEEHNIVFMPVIGK 20 1 Q9UBB9;Q9UBB9-2 Q9UBB9 TFIP11 Tuftelin-interacting protein 11 1 71516000.0 24006000.0 24668000.0 22842000.0 True False 31076240.229004785 23295204.115085263 18684990.37871218 1.0 0.7496146233720659 0.6012629018510637 24.88930863349509 -11.90170165165123 0.06967306224192216 2.155388103414491 2.7877904822641087e-13 0.9999574120414482 0.001073833187913956 5.4898095610094035 0.05189913989184042 1.398814772769809 0.43864981757349375 1.2540023441834994e-12 11.90170165165123 -2.155388103414212 DLIHDVSFDFHGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLIHDVSFDFHGR 13 0 Q96EE3;Q96EE3-1;K7ELV2;K7ENI5;K7EP88 Q96EE3 SEH1L Nucleoporin SEH1 0 9386200.0 2903300.0 3891500.0 2591400.0 False True 3806254.4155971976 3310903.3689481886 2323266.7864640597 1.0 0.869858660887415 0.6103813704474984 21.85994056600002 -6.960105395400028 0.43394580526228643 1.0098857092689817 0.4603386904318489 0.9997740873217189 0.0024342563003541427 0.07966349354902512 0.020992352696219005 0.00339712313484592 0.021525648039178193 1.096212133042136e-07 6.960105395400028 -0.5495470188371328 DLIHDVSFDFHGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLIHDVSFDFHGR 13 0 Q96EE3;Q96EE3-1;K7ELV2;K7ENI5;K7EP88 Q96EE3 SEH1L Nucleoporin SEH1 0 8210600.0 2570900.0 2270300.0 3369400.0 False True 2489288.186739514 3176842.6294580954 2486853.060166695 1.0 1.2762052406712878 0.9990217578720733 21.247301831186824 -10.795442211516812 4.668280167241918 0.9847339048121581 1.137613499271568 0.24735311587714426 0.11315968299760445 0.019460113629690894 0.000852715730955711 0.11858902510541632 0.03652213064265192 1.6016137495361963e-11 10.795442211516812 0.15287959445941002 DLIHDVSFDFHGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLIHDVSFDFHGR 13 0 Q96EE3;Q96EE3-1;K7ELV2;K7ENI5;K7EP88 Q96EE3 SEH1L Nucleoporin SEH1 0 16393800.0 2968300.0 9788400.0 3637100.0 False True 4503128.111797576 8041583.5428817235 2918225.5908024395 1.0 1.7857772071404945 0.6480440969816271 22.102496091557764 -6.720874941999331 1.7560229674350347 1.4775988350578235 0.6497100366316808 0.5167411293016966 0.3306217810249697 0.3536038524753428 2.131395380012995 0.1494644176730321 0.37484641870533325 1.901625786953977e-07 6.720874941999331 -0.8278887984261427 DLIHDVSFDFHGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLIHDVSFDFHGR 13 0 Q96EE3;Q96EE3-1;K7ELV2;K7ENI5;K7EP88 Q96EE3 SEH1L Nucleoporin SEH1 0 5798800.0 2903300.0 2895500.0 0.0 False True 3976728.4687323924 2767567.23586194 0.0 1.0 0.6959407104664904 0.0 21.92315062752291 -7.436836576509358 0.7431537452505829 0.9912786617955625 8.903671847961828e-18 0.9872733854565866 0.04721951254614653 0.1157164910966081 0.14009678192091662 0.04116535977127788 0.0740715541295487 3.6573238953839794e-08 7.436836576509358 -0.9912786617955625 down DLIHDVSFDFHGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLIHDVSFDFHGR 13 0 Q96EE3;Q96EE3-1;K7ELV2;K7ENI5;K7EP88 Q96EE3 SEH1L Nucleoporin SEH1 0 6802100.0 2570900.0 1372400.0 2858800.0 False True 2137817.260181081 1365006.608799928 3456561.8624022594 1.0 0.6385048124666685 1.61686498036295 21.0277071066211 -6.806669576530158 1.428455304742601 0.802199651626002 1.6327129477451041 0.8509638830695696 0.15593556810215023 0.21137563321581992 0.85066690990804 0.08585105841791989 0.19891041112245525 1.5607395057772904e-07 6.806669576530158 0.8305132961191021 DLIHGAPVGK(ub)PAANR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLIHGAPVGKPAANR 15 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 11731800.0 3893200.0 5407400.0 2431200.0 True False 5104022.901802432 4600636.997880112 2179642.7457171497 1.0 0.9013746776597429 0.42704407633974995 22.283203371828733 -6.940676030707244 0.6532462556636415 1.0052684542349488 0.2965485884006725 0.9982510839718733 0.010459608112698339 0.08745963553509957 0.05321578655474683 0.010234551155840812 0.04070463400275476 1.146367774941329e-07 6.940676030707244 -0.7087198658342764 down DLIHGAPVGK(ub)PAANR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLIHGAPVGKPAANR 15 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 14831000.0 3326600.0 4585600.0 6918800.0 True False 3220998.9038887755 6416653.993588097 5106558.720449127 1.0 1.9921316911474711 1.5853959820613035 21.61907673909349 -10.213687222094993 4.761023019019552 0.9998576711512789 1.7887638366070913 0.8337289083779494 0.16604915791433614 0.0002509052827015672 4.143841629113147e-05 0.16080501697034458 0.05359213526984581 6.113821824532988e-11 10.213687222094993 0.7889061654558124 DLIHGAPVGK(ub)PAANR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLIHGAPVGKPAANR 15 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 38272200.0 7341200.0 6235000.0 24696000.0 True False 11137137.113609921 5122315.535722651 19814824.77535866 1.0 0.4599310831383251 1.7791668157828764 23.408875088737673 -6.795553870425616 1.474062335535752 0.7003222461160843 1.7954272684804324 0.8188273389728709 0.23049302911253597 0.22716564322944025 0.9748911886388788 0.12304237650202868 0.2869525497309297 1.6012020209430846e-07 6.795553870425616 1.0951050223643481 DLIHGAPVGK(ub)PAANR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLIHGAPVGKPAANR 15 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 10239200.0 3893200.0 3003000.0 3343000.0 True False 5332621.24977403 2870317.5304069747 2553452.2512461725 1.0 0.5382564026141186 0.4788362292473659 22.346413433351625 -13.999999999999998 0.289064631520436 4.95793829680261 0.4624908921231709 0.9996253690833209 0.004508640493907816 15.910440128629663 0.17047936855802975 37.427105471395414 0.022536830575339388 1.0000000000000041e-14 13.999999999999998 -4.495447404679439 DLIHGAPVGK(ub)PAANR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLIHGAPVGKPAANR 15 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 12804200.0 3326600.0 6398900.0 3078700.0 True False 2766215.293367448 6364427.855617794 3722441.9356995416 1.0 2.3007709742903155 1.3456804843154608 21.399482014527766 -10.170154510777952 4.725304699802076 0.999901316151078 1.823225729308337 0.4976327103818584 0.3899140597892282 0.00040541296988315113 7.119831567184187e-05 0.37757747492662963 0.1258442216653333 6.758424852854265e-11 10.170154510777952 0.8233244131572589 DLIHGAPVGK(ub)PAANR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLIHGAPVGKPAANR 15 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 27235400.0 7341200.0 8354200.0 11540000.0 True False 9503328.11668624 7889281.426067992 9439838.410399185 1.0 0.8301598481289671 0.9933192134894746 23.180001410830123 -10.625045303544775 7.794202622467215 1.0001055099344964 0.9117395308122267 0.28066040533465775 0.066609531981596 0.00012227022480778088 5.881963723394426e-06 0.06457127397962616 0.021498134005282634 2.371126348082537e-11 10.625045303544775 -0.08836597912226973 DLIK(ub)LAGVTLGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLIKLAGVTLGQR 13 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 10528800.0 2382100.0 3865000.0 4281700.0 True False 3122956.1682892162 3288357.0656520016 3838670.7569665723 1.0 1.0529629262947335 1.2291785571455622 21.57448089012821 -6.949104205232997 0.5686000450236289 0.9977908577139348 1.2928974203540788 0.9991290425233422 0.0028912292667076698 0.08384760084757871 0.037467566987398185 0.0030679940934268276 0.014677199570480146 1.1243351670271316e-07 6.949104205232997 0.295106562640144 DLIK(ub)LAGVTLGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLIKLAGVTLGQR 13 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 19602700.0 5948800.0 7619700.0 6034200.0 True False 5759958.600208485 10662285.946210569 4453661.99788029 1.0 1.8511046148534196 0.7732107653897179 22.45762701163611 -6.696216243908121 1.8444028343384284 1.5304456119589638 0.776637350071524 0.3996577246391203 0.35951568650537663 0.4034276770262695 2.6653981004680536 0.15566584849916454 0.4022060173901633 2.0127218258695135e-07 6.696216243908121 -0.7538082618874398 DLIK(ub)LAGVTLGQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLIKLAGVTLGQR 13 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 18373100.0 3445100.0 0.0 14928000.0 True False 5226468.570546716 0.0 11977474.256825157 1.0 0.0 2.291695452704549 22.31740504225997 -6.788097686125937 1.5038756806154905 0.4397162692468003 2.314824806071583 0.7951192032520674 0.42462095945894923 0.2381980447851972 1.0642777819120122 0.2222661632125138 0.5211207895289501 1.628929595290249e-07 6.788097686125937 1.8751085368247828 DLIK(ub)LAGVTLGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLIKLAGVTLGQR 13 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 9192100.0 2382100.0 2800500.0 4009500.0 True False 3262826.7438319945 2676764.6499849274 3062538.6782445507 1.0 0.820382098143902 0.9386151698167653 21.637690951651102 -10.220449757759555 5.316601870868829 1.0000086384051519 0.8794986339948045 0.580709958155655 0.0482684493868149 4.9426977693946335e-06 7.247352562524078e-07 0.04673907495810573 0.015578575051854697 6.019358950500161e-11 10.220449757759555 -0.12051000441034732 DLIK(ub)LAGVTLGQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLIKLAGVTLGQR 13 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 14773200.0 5948800.0 5619000.0 3205400.0 True False 4946690.77652386 5588729.331715822 3875634.3199049337 1.0 1.1297915281543303 0.7834802082834902 22.238032287070386 -6.805173397056682 1.434515005148955 1.0711495047351434 0.7780560088213972 0.8469045391755906 0.055893982155194095 0.2134554642935776 0.8665496441401674 0.030643962951881022 0.07106004900960537 1.5661256516214838e-07 6.805173397056682 -0.2930934959137461 DLIK(ub)LAGVTLGQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLIKLAGVTLGQR 13 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 15173300.0 3445100.0 4532200.0 7196000.0 True False 4459749.863073582 4279979.085876014 5886401.8371952 1.0 0.9596903901077374 1.3198950654013575 22.08853136435242 -6.879106165906773 1.0847183463948105 0.9752972076695832 1.3449944304902068 0.9729596198372792 0.026498375528585503 0.12842730621589268 0.2770656798150409 0.018832237776155985 0.045441566915413824 1.320972674971951e-07 6.879106165906773 0.36969722282062367 DLILPTIQK(ub)SLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLILPTIQKSLLR 13 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 5972410.0 1016600.0 2735200.0 2220610.0 True False 1332772.4447684041 2327118.8217260954 1990842.5787952305 1.0 1.7460736308443703 1.4937603089034297 20.34599904755404 -10.280081723035059 5.235197864405031 0.9998944595603555 1.6199169698739837 0.8894868156780017 0.10300648234394018 0.00012690881165035368 1.7451854733552374e-05 0.09975241428415654 0.03324519922241518 5.247087142946112e-11 10.280081723035059 0.6200225103136282 DLILPTIQK(ub)SLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLILPTIQKSLLR 13 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 31690900.0 1824000.0 5085900.0 24781000.0 True False 2767141.3522618236 4178281.4086819263 19883024.488101836 1.0 1.5099631268444802 7.185402535309489 21.399964911500625 -6.92450865818614 0.7905553663311004 0.8939298073445228 8.202818401738842 0.9953447515029159 0.19127210531593525 0.09559082916097719 0.0923915830932933 0.16886716965929835 0.5298762376386453 1.1898476078714048e-07 6.92450865818614 7.308888594394319 up DLILPTIQK(ub)SLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLILPTIQKSLLR 13 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 7215260.0 1016600.0 2372560.0 3826100.0 True False 1392464.492582009 2267732.4541932656 2922453.9810029846 1.0 1.628574707846425 2.098763736218478 20.409209109076933 -6.974322172359837 0.11493939574556726 0.08551816737419839 3.653859581001072 0.9999995404191977 0.00030509193495826983 0.07492340933285424 0.003409558769356282 0.035158700337452956 0.06980813118186172 1.060908252414209e-07 6.974322172359837 3.5683414136268734 DLILPTIQK(ub)SLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLILPTIQKSLLR 13 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 30691500.0 1824000.0 2693500.0 26174000.0 True False 2361203.9564152597 2543604.3572232104 21410600.567919288 1.0 1.0772488968233256 9.067662498933172 21.171091233593074 -6.9090130891106165 0.9024020720772548 0.7448112365075542 10.078877301082594 0.9905444087585075 0.3680583535360989 0.1050750354523619 0.1423237128118752 0.29987137491746113 0.8222567512583188 1.233067669500114e-07 6.9090130891106165 9.33406606457504 up DLINLAK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLINLAKK 8 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 8681800.0 2190400.0 3740100.0 2751300.0 True False 2871635.611863776 3182091.658795613 2466621.8683331674 1.0 1.1081112261072503 0.8589606070291965 21.453441263363498 -6.788802977349112 1.5014067186257676 1.0605178460392568 0.8564082584245302 0.7973294166528687 0.045924275963603274 0.23714299049068158 1.0561349388337218 0.024079096606226553 0.056417486088759 1.6262863718068579e-07 6.788802977349112 -0.20410958761472664 DLINLAK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLINLAKK 8 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 11849100.0 2421300.0 3217700.0 6210100.0 True False 2344437.1568526137 4502544.39008383 4583488.510993402 1.0 1.92052253434187 1.9550485700144318 21.160810177147162 -11.038086116937441 0.566376386554992 3.4706013813496688e-12 1.951658826944916 0.9998883174532599 0.004674231763475986 2.9613078986556967 0.27792153323614704 3.843788830947929 0.006289102475707391 9.16038829328176e-12 11.038086116937441 1.9516588269414454 DLINLAK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLINLAKK 8 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 7021500.0 2190400.0 2666200.0 2164900.0 True False 3000250.073334286 2548398.4680556394 1653595.2075150602 1.0 0.8493953523092534 0.551152459660591 21.51665132488639 -6.960238043220054 0.4320672385917583 1.011590164776085 0.3774814278465549 0.9997789220057152 0.002773246148200041 0.0796162180643947 0.020818051256026534 0.0038969740176902413 0.02475173549656724 1.0958773649261881e-07 6.960238043220054 -0.6341087369295301 DLINLAK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLINLAKK 8 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 7559300.0 2421300.0 2978300.0 2159700.0 True False 2013418.231777374 2962255.3067537346 2611283.284675446 1.0 1.4712568208636718 1.29694031943393 20.94121545258144 -10.016938108774132 5.576082736161408 0.9999987329186493 1.384098570149053 0.8661960094811425 0.07116441370922238 1.1209726377162611e-06 1.975795605543e-07 0.06890487520676848 0.022968215761406983 9.617493273358427e-11 10.016938108774132 0.38409983723040364 DLIQDQNMDEK(ub)GK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLIQDQNMDEKGK 13 1 Q9H307 Q9H307 PNN Pinin 1 7017200.0 2347700.0 1992100.0 2677400.0 True False 2273173.5485660075 2787555.9186642612 1976108.6197216997 1.0 1.2262838094446167 0.8693170923831548 21.11627640222502 -6.73542827288466 1.7036217171629933 1.1353471938653563 0.8693170002444318 0.5841766520279572 0.09509048227048071 0.3261461950100642 1.8567913394210809 0.0441915670094114 0.10898326600822945 1.8389576469592167e-07 6.73542827288466 -0.2660301936209245 DLIQDQNMDEK(ub)GK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLIQDQNMDEKGK 13 1 Q9H307 Q9H307 PNN Pinin 1 7703200.0 2347700.0 3877500.0 1478000.0 True False 1952216.5707445317 3856611.137876512 1787042.9665001202 1.0 1.9755037405535836 0.9153917620003512 20.896681677659295 -6.664751757978432 1.9557213444963792 1.6254269264732024 0.9197327128453054 0.2561710927751537 0.4148762455491772 0.47324883969149817 3.4843624856844073 0.1710817741151919 0.46028166579911467 2.1639550835020529e-07 6.664751757978432 -0.705694213627897 DLIQDQNMDEK(ub)GK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLIQDQNMDEKGK 13 1 Q9H307 Q9H307 PNN Pinin 1 9829600.0 3684600.0 3994600.0 2150400.0 True False 4769787.334324381 3772296.9984643934 1759049.264967279 1.0 0.7908732054609983 0.36878987293810667 22.185493513006694 -6.959866089153026 0.4373160726510409 1.0155212483426062 0.12775850484509985 0.9997652025335457 0.0040228236618346696 0.07974897997373609 0.021308245997655215 0.005546934774989509 0.03499056045366866 1.0968163375870513e-07 6.959866089153026 -0.8877627434975063 down DLISHDEMFSDIYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLISHDEMFSDIYK 14 0 P13693;Q5W0H4;A0A0B4J2C3 P13693 TPT1 Translationally-controlled tumor protein 0 22690100.0 2661200.0 9953400.0 10075500.0 False True 3488858.9710974586 8468391.518049331 9032983.911020547 1.0 2.427266790719691 2.5890940235337525 21.734323850487733 -10.537011920426842 0.43641590095077065 7.738883998984603e-15 2.59477210758567 0.9994298138072972 0.017049920530085347 1.9967366525463701 0.20687313171155733 2.2506923841656468 0.03756381289880059 2.9039429465336248e-11 10.537011920426842 2.5947721075856625 DLISHDEMFSDIYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLISHDEMFSDIYK 14 0 P13693;Q5W0H4;A0A0B4J2C3 P13693 TPT1 Translationally-controlled tumor protein 0 17737300.0 8899500.0 3260600.0 5577200.0 False True 8616990.24384001 4562574.583804368 4116364.007586423 1.0 0.529485870900921 0.4777032224829394 23.03875261978514 -13.999999999999988 0.3115998010527146 5.5909610266753464 0.4664310269026209 0.9996755069881745 0.004232505758448598 17.384513223391657 0.17767290355008244 51.79292567347174 0.01782777506027428 1.0000000000000286e-14 13.999999999999988 -5.124529999772726 DLISHDEMFSDIYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLISHDEMFSDIYK 14 0 P13693;Q5W0H4;A0A0B4J2C3 P13693 TPT1 Translationally-controlled tumor protein 0 23728100.0 2661200.0 9210900.0 11856000.0 False True 3645117.556225892 8803931.981626907 9055856.981984645 1.0 2.415266955269993 2.4843799527170702 21.797533912010625 -10.698308270238483 0.5619307154479425 2.3667551090207324e-16 2.477981803429065 0.9998172950358171 0.009245996530422856 2.233688853974343 0.27288152730364873 3.08745213424003 0.012661134679940617 2.0030497209754938e-11 10.698308270238483 2.4779818034290644 DLISHDEMFSDIYK(ub)IR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLISHDEMFSDIYKIR 16 1 P13693;Q5W0H4;A0A0B4J2C3 P13693 TPT1 Translationally-controlled tumor protein 1 18851000.0 7215300.0 5614400.0 6021300.0 True False 5999841.641987069 5584154.112828859 7280325.990654384 1.0 0.9307169165517276 1.213419690897581 22.516492992489514 -6.841926268892815 1.2736412311027185 0.9631497667119426 1.2230649808942455 0.9276781564542596 0.0323544461955968 0.16656506771856192 0.5240573594654083 0.019913977077063213 0.04589859592163478 1.4390428669175584e-07 6.841926268892815 0.2599152141823029 DLISHDEMFSDIYK(ub)IR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLISHDEMFSDIYKIR 16 1 P13693;Q5W0H4;A0A0B4J2C3 P13693 TPT1 Translationally-controlled tumor protein 1 27844100.0 3982000.0 3073700.0 20788400.0 True False 5154777.496954804 2902645.893000547 17005124.50699676 1.0 0.5630981928347617 3.298905630173673 22.297478725148835 -6.866019218705613 1.1550353959602766 0.7579841998386406 3.447399792823879 0.9605412556192866 0.23837523292363397 0.14072398159638275 0.35340485238768915 0.1605319907610991 0.3776285413139327 1.3613844361890126e-07 6.866019218705613 2.689415592985238 up DLIVATIAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLIVATIAVK 10 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 42094000.0 10277000.0 18188000.0 13629000.0 False True 15590960.349339228 14942209.296507379 10935222.176197106 1.0 0.9583892821035015 0.701382206815795 23.89420646001873 -6.935224246315662 0.7025844205719273 1.0032558731612853 0.6408380377774847 0.9974690982472 0.006643640439676947 0.09001441992213195 0.06504599295442191 0.0062532879211905255 0.022624150508491876 1.1608490590369286e-07 6.935224246315662 -0.36241783538380057 DLIVATIAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLIVATIAVK 10 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 1821720.0 751920.0 1069800.0 0.0 False True 1029925.1438739572 1022532.6986444831 0.0 1.0 0.9928223470672167 0.0 19.974108053833337 -7.0290621243897435 1.0794187575651206 1.0197418503405329 4.377438584869474e-18 0.9864035912105726 0.05477127959345853 0.0871724733232549 0.19688278187182365 0.04271967879660687 0.0771825608232454 9.352718770284102e-08 7.0290621243897435 -1.0197418503405329 down DLIVATIAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLIVATIAVK 10 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 2548540.0 1712300.0 0.0 836240.0 False True 1423853.3177517834 0.0 1011093.9176630992 1.0 0.0 0.7101110100720084 20.44136910000214 -10.572358845028626 8.672913737606406 1.00012607456867 0.3550555071669544 0.5237740517431333 0.2899016059014644 0.0007068497433491051 3.485315528702289e-05 0.2807491077769176 0.09356534097459641 2.6769555194703947e-11 10.572358845028626 -0.6450705674017156 DLIVATIAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLIVATIAVK 10 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 33186600.0 10277000.0 14130000.0 8779600.0 False True 13303779.089955932 13343653.078731729 7181802.886303359 1.0 1.0029971926402401 0.5398317904816584 23.66533278211118 -6.905441080454107 0.9262098131122518 1.0164889267713304 0.48546174043937884 0.989084763564447 0.02273766253996419 0.1075108459351945 0.15568629488920535 0.018205817074403594 0.04880289954041603 1.2432512929101618e-07 6.905441080454107 -0.5310271863319516 DLK(ub)ASVWQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLKASVWQK 9 1 Q9HCU5;B5MC98 Q9HCU5 PREB Prolactin regulatory element-binding protein 1 8292600.0 1453300.0 1298400.0 5540900.0 True False 1407165.7869961995 1816857.8910665505 4089572.0665630777 1.0 1.2911470047498088 2.9062475113844726 20.424360880831852 -6.937516774955312 0.6822714932404933 0.9808575023557062 3.3117158756822054 0.9978202623201489 0.03914560968571302 0.08891793205805361 0.05990624948641794 0.03742328720153298 0.14059678380399532 1.1547373812167401e-07 6.937516774955312 2.330858373326499 up DLK(ub)ASVWQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLKASVWQK 9 1 Q9HCU5;B5MC98 Q9HCU5 PREB Prolactin regulatory element-binding protein 1 5748000.0 1453300.0 2120100.0 2174600.0 True False 1208483.3421063283 2108678.6004931 2629298.8057856327 1.0 1.7448967040106442 2.175701322620543 20.20476615626613 -9.197827524085426 0.15147237671503233 1.35786059635841e-23 2.8792180552025375 0.9998103401383784 0.006688279684569561 0.6502300917781343 0.054017495010574325 0.6263940221990496 0.3357825858795823 6.341214965656053e-10 9.197827524085426 2.8792180552025375 DLK(ub)ASVWQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLKASVWQK 9 1 Q9HCU5;B5MC98 Q9HCU5 PREB Prolactin regulatory element-binding protein 1 7462200.0 0.0 2144600.0 5317600.0 True False 0.0 2025251.12474509 4349851.363183604 0.0 DLK(ub)IITDVIGNPEEERR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLKIITDVIGNPEEERR 17 2 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 17282600.0 3541400.0 8081200.0 5660000.0 True False 4642809.694966385 6875516.460270883 5074357.494553745 1.0 1.480895602446325 1.0929497067379765 22.146566716531783 -10.223242876915146 5.108581955114681 0.9999691238572344 1.2869226545922883 0.42174249972501043 0.1583782487159195 5.570329244489785e-05 8.469697476136447e-06 0.15336556393777287 0.05111635997311388 5.98077030069497e-11 10.223242876915146 0.2869535307350539 DLK(ub)IITDVIGNPEEERR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLKIITDVIGNPEEERR 17 2 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 38278600.0 11155000.0 8612600.0 18511000.0 True False 10800890.630938288 12051656.094115663 13662413.781903483 1.0 1.1158020672475526 1.2649339993100746 23.364646944735494 -6.967667651785725 0.30885929997725614 0.9767132997991015 1.4087554182394901 0.9999580471492087 0.0007023776846424625 0.0770670029635996 0.011725272419072053 0.0023718297295514017 0.013254787433849063 1.0772893047282238e-07 6.967667651785725 0.43204211844038864 DLK(ub)IITDVIGNPEEERR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLKIITDVIGNPEEERR 17 2 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 71692000.0 19477000.0 16017000.0 36198000.0 True False 29548032.959431764 13158641.208607795 29043449.43385302 1.0 0.4453305310263485 0.9829232786401885 24.81655875623432 -10.866869927609292 10.585258466873267 1.0111418435989545 0.7141269048332686 0.2738005962143073 0.21947132017912113 0.05584320216621796 0.0007023349065547984 0.20563418096755928 0.070834064001991 1.358720326124583e-11 10.866869927609292 -0.29701493876568597 DLK(ub)IITDVIGNPEEERR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLKIITDVIGNPEEERR 17 2 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 20869000.0 3541400.0 10994000.0 6333600.0 True False 4850751.282736502 10508248.727703732 4837734.124586532 1.0 2.1663136522999817 0.9973164655552849 22.209776778054675 -6.646669116959272 2.0201808503266263 1.7587854195371606 1.0021909663185313 0.18080064499343018 0.49820043630618155 0.5167023318322221 4.03795472650197 0.20025769784717437 0.5518352135473554 2.2559573406800525e-07 6.646669116959272 -0.7565944532186293 DLK(ub)IITDVIGNPEEERR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLKIITDVIGNPEEERR 17 2 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 32090400.0 11155000.0 9578400.0 11357000.0 True False 9275876.750289755 9526799.258036448 13731696.191165004 1.0 1.027051082555496 1.480366391321021 23.14505222016977 -6.919127992927116 0.8311524501637615 0.989680500989575 1.5520251517009294 0.9939357100197106 0.017159265185599317 0.09868728592724041 0.10828712948034874 0.014716685076908249 0.04372365568481848 1.204680851007013e-07 6.919127992927116 0.5623446507113543 DLK(ub)IITDVIGNPEEERR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLKIITDVIGNPEEERR 17 2 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 96208000.0 19477000.0 15992000.0 60739000.0 True False 25213360.44906799 15102031.141902197 49685125.23476921 1.0 0.5989693905502566 1.9705871946397298 24.587685078326768 -6.82844221949247 1.3348742004729357 0.785476578543614 2.006332255293517 0.9027242118767056 0.17959536330152534 0.18273767040601288 0.6373745255136896 0.10565388024360936 0.24315717237667012 1.4844233613436828e-07 6.82844221949247 1.220855676749903 DLK(ub)LDNVLLDSEGHIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLKLDNVLLDSEGHIK 16 1 P41743 P41743 PRKCI Protein kinase C iota type 1 12698900.0 1824200.0 1814000.0 9060700.0 True False 1766291.769516596 2538339.659885028 6687430.854826483 1.0 1.4371009952561395 3.786141661440634 20.752292247342368 -6.938208973634749 0.6760184680586329 0.9726374916508217 4.387568784946628 0.9979198030940325 0.05580088858225788 0.08859326348841846 0.058401876019328294 0.05360744963658916 0.20382411711855736 1.1528983731816087e-07 6.938208973634749 3.414931293295806 up DLK(ub)LDNVLLDSEGHIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLKLDNVLLDSEGHIK 16 1 P41743 P41743 PRKCI Protein kinase C iota type 1 34622100.0 4102600.0 6245500.0 24274000.0 True False 5310896.574336209 5897932.434764267 19856381.07227298 1.0 1.1105342294302594 3.7388001807876967 22.340524003641914 -6.915736519340683 0.8557531276412245 0.9326287410930937 4.123681752484118 0.9929121599949113 0.10656970896174717 0.10074604289432391 0.11909501393075077 0.08980448326605746 0.2589555609946244 1.2141252206181606e-07 6.915736519340683 3.1910530113910243 up DLK(ub)PNGANILVTEENKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLKPNGANILVTEENKK 17 2 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 9761400.0 2871900.0 2719300.0 4170200.0 True False 3765088.7115191617 2313591.0397483823 3738707.707383047 1.0 0.6144851335560909 0.9929932582848837 21.84425242682722 -10.841260569898818 10.182687566707479 1.0047472221197278 0.8037391959204874 0.26387893255228023 0.1545252948472123 0.01684799561572049 0.0002626453563320547 0.1513665071565887 0.04987282445925363 1.4412503643771884e-11 10.841260569898818 -0.2010080261992404 DLK(ub)PNGANILVTEENKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLKPNGANILVTEENKK 17 2 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 8145300.0 2871900.0 2990800.0 2282600.0 True False 3933719.0401792955 2858656.566746982 1743496.8916226486 1.0 0.7267058316947533 0.44321845912594243 21.907462488350113 -6.970665154505864 0.24177073312063832 1.0995830034540712 0.06212380172418125 0.9999871154981989 0.0008159365824102433 0.07608743448863202 0.008254013254807102 0.006692323452117057 0.02755076443116257 1.0698794493202861e-07 6.970665154505864 -1.03745920172989 down DLK(ub)PQNLLIDDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLKPQNLLIDDK 12 1 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 8166400.0 1857300.0 2388700.0 3920400.0 True False 2434938.2861187854 2032315.271079672 3514754.615132246 1.0 0.8346475484268303 1.4434676374219955 21.215453776769916 -6.834362765877819 1.3083495371443663 0.9118785441223172 1.4613542080241062 0.9143130925187859 0.07524416965743848 0.17548880299157169 0.5859455973115902 0.04513381857257792 0.1038726074249745 1.4643241809988629e-07 6.834362765877819 0.549475663901789 DLK(ub)PQNLLIDDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLKPQNLLIDDK 12 1 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 13077900.0 2701100.0 2798500.0 7578300.0 True False 2615355.0590073904 3915955.643984712 5593315.88587322 1.0 1.497294078866271 2.138644948650322 21.318575388491148 -6.967645977593642 0.3092911603359252 0.9003638591079599 2.7559409194486735 0.9999577620814764 0.0030291352045110948 0.07707418140132218 0.011750398842144757 0.010180126478998849 0.05697896211490449 1.0773430699933767e-07 6.967645977593642 1.8555770603407136 DLK(ub)PQNLLIDDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLKPQNLLIDDK 12 1 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 34481300.0 3374300.0 6874000.0 24233000.0 True False 5119059.7943734 5647280.9931928655 19443336.92829877 1.0 1.1031871515546778 3.7982242265796273 22.28744742748823 -6.914985723650677 0.8610883720392323 0.9291272135424562 4.186378913139026 0.9926708805155391 0.11090462193096043 0.10121319970668877 0.12156601809029424 0.09309933925352146 0.26680575888300967 1.2162259803888964e-07 6.914985723650677 3.25725169959657 up DLK(ub)PQNLLIDDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLKPQNLLIDDK 12 1 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 8022400.0 1857300.0 2192800.0 3972300.0 True False 2543994.0016452544 2095914.8453800923 3034124.5520865032 1.0 0.8238678408929503 1.1926618341569482 21.278663838292807 -6.77683522241001 1.5482301962385197 0.8998604456338775 1.1952974025697138 0.756034747153017 0.07439051439064127 0.25551594409335754 1.2095236572638266 0.037853343833930575 0.08955610304809107 1.6717247704872583e-07 6.77683522241001 0.2954369569358364 DLK(ub)PQNLLIDDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLKPQNLLIDDK 12 1 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 12668400.0 2701100.0 4075100.0 5892200.0 True False 2246084.329019066 4053146.627455979 7124231.777545333 1.0 1.8045389369802125 3.17184519098475 21.098980663925424 -6.963099855470255 0.38929542648389215 0.9153629753636392 4.1100938922292505 0.9998684491330326 0.010282682022735547 0.07861188889565351 0.01717179948726238 0.017660656685220183 0.1150498199598761 1.0886797490820676e-07 6.963099855470255 3.1947309168656113 DLK(ub)PQNLLIDDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLKPQNLLIDDK 12 1 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 35770200.0 3374300.0 3890900.0 28505000.0 True False 4368097.8673969405 3674367.9946240196 23317382.485999063 1.0 0.8411826168202747 5.338108987904723 22.05857374958068 -6.898713804232381 0.9693774299568906 0.8063789071800362 5.797975813977465 0.9859150566295827 0.24726348804038897 0.1123577409546633 0.18281368825464678 0.1917634759377546 0.4957852613057531 1.262659340500048e-07 6.898713804232381 4.991596906797429 up DLK(ub)PQNLLIDDKGTIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLKPQNLLIDDKGTIK 16 2 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 3367700.0 848700.0 988700.0 1530300.0 True False 1112653.918822491 841189.8139224142 1371959.2356741326 1.0 0.7560210768975099 1.2330511873144359 20.085573494223006 -6.767633450578364 1.5832060167455677 0.8596445624966916 1.23551937333201 0.721594452197407 0.10276544106060966 0.2702433674349466 1.3364075356037672 0.051171818314280165 0.12209171370605452 1.707522949544875e-07 6.767633450578364 0.3758748108353184 DLK(ub)PQNLLIDDKGTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLKPQNLLIDDKGTIK 16 2 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 4680800.0 848700.0 1544500.0 2287600.0 True False 1162487.3252551157 1476258.8830215028 1747315.9946008832 1.0 1.2699139603070748 1.5030839103707414 20.148783555745897 -6.972833562983561 0.17792409426190922 0.8147114495431388 1.9645788262637311 0.9999968830105848 0.00036288021137744777 0.07539350599210907 0.0055981095287947966 0.009146183666020446 0.026334108313771098 1.0645509136470765e-07 6.972833562983561 1.1498673767205925 DLK(ub)THPEVCGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLKTHPEVCGR 11 1 O14545;F8VNX8 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 39530000.0 15059000.0 14417000.0 10054000.0 True False 19742494.831563443 12266039.797025846 9013708.52477799 1.0 0.6213014060115358 0.4565638031910366 24.234800976888156 -13.999999999995676 0.11328113169275768 2.8178620755389487 0.16814846068314246 0.9997264409272311 0.003763033060584602 11.994329191463901 0.10265405880174366 4.958165112280534 0.25600515603969154 1.0000000000099556e-14 13.999999999995676 -2.6497136148558065 DLK(ub)THPEVCGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLKTHPEVCGR 11 1 O14545;F8VNX8 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 24382500.0 9660000.0 9459900.0 5262600.0 True False 9353348.587616663 13237287.40272678 3884167.185384118 1.0 1.4152458104953178 0.41527022637930433 23.157051525327127 -6.793908287338107 1.4805780377966364 1.2309006171743495 0.4034416665006231 0.8137959056652807 0.177001833442167 0.229557407809101 0.9939644607505288 0.09407788567612596 0.2196590142905641 1.6072806366069584e-07 6.793908287338107 -0.8274589506737264 down DLK(ub)THPEVCGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLKTHPEVCGR 11 1 O14545;F8VNX8 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 88124000.0 26300000.0 27468000.0 34356000.0 True False 39899022.78754715 22566120.791536476 27565521.5412303 1.0 0.565580789075856 0.6908821223018462 25.24985007640291 -10.488791062093282 9.176229252692897 1.0000075735976728 0.6282314556888542 0.9214911626928267 0.05115405508235335 7.926057469416036e-06 4.4154202094585834e-07 0.0495307088814657 0.016509900285410963 3.244956938075495e-11 10.488791062093282 -0.3717761179088186 DLK(ub)THPEVCGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLKTHPEVCGR 11 1 O14545;F8VNX8 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 36202800.0 15059000.0 11817000.0 9326800.0 True False 20626719.254173193 11294885.866406681 7124001.931475562 1.0 0.5475851844020955 0.3453773643636632 24.298011038411047 -13.227280614018355 0.11737695258853811 2.8248996921698915 4.0047819913061935e-21 0.999731795367671 0.0044820121521201165 9.1297547411255 0.09729395105015631 4.121378229699481 0.2901910749335247 5.925423369455508e-14 13.227280614018355 -2.8248996921698915 DLK(ub)THPEVCGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLKTHPEVCGR 11 1 O14545;F8VNX8 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 27593700.0 9660000.0 8671200.0 9262500.0 True False 8032718.010560201 8624486.524501558 11199245.925038818 1.0 1.0736697731905178 1.394203793823678 22.937456800761403 -6.942947824918526 0.6315483353003578 0.996503122386667 1.4886912619191504 0.9985250322743779 0.006572255940172861 0.08644726291279911 0.048676964617650906 0.006550720428469016 0.027249760656287952 1.1403867826229043e-07 6.942947824918526 0.4921881395324833 DLK(ub)THPEVCGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLKTHPEVCGR 11 1 O14545;F8VNX8 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 112031000.0 26300000.0 34308000.0 51423000.0 True False 34045868.45050513 32398729.64084423 42064541.644537084 1.0 0.9516200089871268 1.235525588242499 25.02097639849536 -6.8630274999110235 1.1704255229177911 0.9735114144228766 1.250084822823894 0.9572106415083624 0.025653030542459945 0.14371088599084422 0.3723965058709729 0.0170732444956294 0.039997642374974426 1.370794963466182e-07 6.8630274999110235 0.2765734084010175 DLK(ub)TMTDVVGNPEEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLKTMTDVVGNPEEER 16 1 Q96GM5;F8VRQ4;H0YHV1 Q96GM5 SMARCD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 1 19290000.0 4417300.0 6055100.0 8817600.0 True False 5791123.077194055 5151702.682594942 7905239.336391724 1.0 0.8895861154950746 1.3650615314192238 22.465411727690547 -6.845558166503343 1.2563380734000618 0.9412336786249128 1.382501474688612 0.9335932463409954 0.052358415864750506 0.16240642272799635 0.49552628036848245 0.032645253541300906 0.07535910503769325 1.4270586866521902e-07 6.845558166503343 0.44126779606369915 DLK(ub)TMTDVVGNPEEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLKTMTDVVGNPEEER 16 1 Q96GM5;F8VRQ4;H0YHV1 Q96GM5 SMARCD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 1 31311200.0 7922500.0 11678700.0 11710000.0 True False 7671004.57405725 16342065.813615942 8642799.707530124 1.0 2.1303684094888378 1.1266842072757213 22.870984090873588 -6.61758576090614 2.1254970144076504 1.75130230847316 1.130459675212205 0.07470595216993903 0.48639866923587244 0.5919891235289001 5.078550751670277 0.18824813694351733 0.5395034876586344 2.412205143103363e-07 6.61758576090614 -0.6208426332609551 DLK(ub)TMTDVVGNPEEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLKTMTDVVGNPEEER 16 1 Q96GM5;F8VRQ4;H0YHV1 Q96GM5 SMARCD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 1 20866400.0 4417300.0 8600400.0 7848700.0 True False 6050495.183043983 8220405.890280446 5994998.709050505 1.0 1.3586335732185129 0.9908277798238726 22.52862178921344 -6.651958098719001 2.0014650208229927 1.2323628168010718 0.99237407186362 0.2019483730624928 0.15299683327830352 0.5038320434864442 3.8707802772356863 0.06194631179975633 0.16948995700052277 2.2286501618846683e-07 6.651958098719001 -0.23998874493745181 DLK(ub)TMTDVVGNPEEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLKTMTDVVGNPEEER 16 1 Q96GM5;F8VRQ4;H0YHV1 Q96GM5 SMARCD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 1 26832100.0 7922500.0 11684700.0 7224900.0 True False 6587909.776259132 11621752.20186864 8735593.18583675 1.0 1.7641031217139584 1.3260037678896621 22.651389366307864 -10.170171591028602 4.370102742379185 0.9998739030590028 1.5450534448251896 0.6736100032342898 0.1788533123320744 26627679.557906713 30984223.739170495 26890.9037255151 0.06122624264537776 6.758159057811132e-11 10.170171591028602 0.5451795417661868 DLK(ub)TMTDVVGNPEEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLKTMTDVVGNPEEER 16 1 Q96GM5;F8VRQ4;H0YHV1 Q96GM5 SMARCD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 1 40474800.0 14496000.0 7868200.0 18110600.0 True False 18765357.758879192 7430327.753296328 14814656.6304485 1.0 0.3959598238824157 0.7894683821542735 24.16156845947457 -10.229037912686637 7.559937147067675 1.000000604608779 0.5927141030183996 0.5881946670249689 0.16064919619738538 1.6370373855369714e-06 1.6678857787477052e-07 0.1555481448129418 0.05184930512117346 5.901495595265663e-11 10.229037912686637 -0.4072865015903795 DLK(ub)TSNLLLSHAGILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLKTSNLLLSHAGILK 16 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 7734800.0 3367200.0 2218200.0 2149400.0 True False 4414431.80801118 1887253.2064758772 1927000.7065006767 1.0 0.42751893982164274 0.4365229298601041 22.07379632644665 -10.231852804524623 5.513093657290047 1.0000330723379645 0.4320209348408412 0.9998115544697814 0.0036758635406705376 1.494327313609214e-06 2.0820808503054297e-07 0.003559346197278914 0.0011863798563123158 5.863368580547645e-11 10.231852804524623 -0.5680121374971232 DLK(ub)TSNLLLSHAGILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLKTSNLLLSHAGILK 16 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 51652200.0 7567100.0 9377100.0 34708000.0 True False 11479843.929112101 7703683.241383304 27847948.58694317 1.0 0.6710616702590606 2.425812472617565 23.452599692616552 -6.858237838287348 1.194569368968021 0.8222911423385474 2.5079833738451676 0.9514611861598482 0.16779179618072249 0.14863476194274974 0.40403331142236754 0.10962636182598597 0.25542074104410456 1.3859965898100345e-07 6.858237838287348 1.68569223150662 up DLK(ub)TSNLLLSHAGILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLKTSNLLLSHAGILK 16 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 9409000.0 3367200.0 2304900.0 3736900.0 True False 4612144.835158505 2203061.8967149626 2854321.1838713204 1.0 0.4776653759701912 0.6188706742495927 22.137006387969542 -10.422822547856983 9.043680982687997 1.0000027231532613 0.5482680251099322 0.9317209530472983 0.05764682162700553 3.165133516440612e-06 2.020557279914148e-07 0.055816630869756016 0.01860543167693184 3.777264979390637e-11 10.422822547856983 -0.4517346980433291 DLK(ub)TSNLLLSHAGILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLKTSNLLLSHAGILK 16 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 12622300.0 2910200.0 3272800.0 6439300.0 True False 2419960.243719697 3255168.776800062 7785727.8580407435 1.0 1.34513316293022 3.21729577097241 21.206551915725047 -6.938004957523546 0.6778675071719464 0.9780839888820714 3.6938481219019654 0.9978907701874443 0.044738621856277264 0.08868864959248106 0.05884301276476665 0.04291762755322345 0.16260041976355555 1.1534400910891029e-07 6.938004957523546 2.715764133019894 up DLK(ub)TSNLLLSHAGILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLKTSNLLLSHAGILK 16 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 86019100.0 7567100.0 6571000.0 71881000.0 True False 9795760.119840972 6205318.073626775 58799395.56134359 1.0 0.6334697866945638 6.002535264440322 23.223726014709 -6.890550356946985 1.0191392819975897 0.7153077962975876 6.469303831483445 0.9812475767269032 0.3353901485843003 0.11869703039947294 0.21925729962032947 0.2505718167381065 0.6259193333261682 1.2866180595296262e-07 6.890550356946985 5.753996035185857 up DLK(ub)VENPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLKVENPEK 9 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 3428000.0 1077300.0 1148100.0 1202600.0 True False 1412350.7325880397 976807.9552587492 1078166.4881537694 1.0 0.691618542561884 0.7633843798686607 20.42966697049141 -9.968432688004592 5.5168952259513535 1.0000005550286466 0.7275014612148366 0.9505524776625575 0.02929828039573621 2.0000580521817944e-07 3.7391658391434464e-08 0.028367995498533003 0.009455979336877168 1.075393264396306e-10 9.968432688004592 -0.27249909381381 DLK(ub)VENPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLKVENPEK 9 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 3321300.0 871000.0 1030000.0 1420300.0 True False 843350.5817612944 1441284.3713790413 1048280.8219133241 1.0 1.7089978978481202 1.2429953148595017 19.685772960202854 -10.286905604004149 4.6533571777364156 0.99977127115846 1.475996606355107 0.5817888583075332 0.1902447578612835 0.00045165605634427033 6.921287972227888e-05 0.18429107866782532 0.0614012315743742 5.1652862705482765e-11 10.286905604004149 0.4762253351966471 DLK(ub)VENPEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLKVENPEK 9 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 8508900.0 1608500.0 3074600.0 3825800.0 True False 2440212.0971015026 2525913.6080405563 3069628.95309229 1.0 1.0351205172045703 1.257935306827801 21.21857511798862 -6.934664898082841 0.7074453566387551 0.9971262931020312 1.3096339881854442 0.9973784162859631 0.005848087675799042 0.09028663875852322 0.06633535500257742 0.005484395293255324 0.01966946984033786 1.1623451342128882e-07 6.934664898082841 0.31250769508341303 DLK(ub)VENPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLKVENPEK 9 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 2842950.0 1077300.0 747550.0 1018100.0 True False 1475606.9229378297 714520.7691827283 777645.7484276793 1.0 0.4842216162554778 0.5270006099452564 20.492877032014302 -9.835974770696 6.711613315628524 1.0000000076134372 0.5056111143118446 0.994415901122232 0.01746445104171262 1.9981951964581016e-09 3.378907444693585e-10 0.016909882512712877 0.005636627336253118 1.458899009078413e-10 9.835974770696 -0.49438889330159264 DLK(ub)VENPEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLKVENPEK 9 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 4151700.0 871000.0 1714200.0 1566500.0 True False 724275.0918424355 1704965.2643579403 1894047.9073223558 1.0 2.354029958452377 2.61509463552614 19.46617823563713 -10.379311257798275 0.3535339275914507 4.606362036154673e-23 2.662737385681717 0.9990831786587412 0.021434498818812802 1.8363889240179745 0.1662572487529022 1.7800251119972577 0.07647577980564133 4.175310159244648e-11 10.379311257798275 2.662737385681717 DLK(ub)VENPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLKVENPEK 9 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 7214500.0 1608500.0 1954500.0 3651500.0 True False 2082234.9582751882 1845730.3568564183 2986964.4675539527 1.0 0.8864179085655743 1.434499241155856 20.98970144008107 -6.852641902439092 1.222144426710395 0.9392175784100827 1.4575673343973494 0.9440742608175228 0.05585636123213128 0.15457930918317023 0.44295425408233724 0.03573529721916964 0.08285214127826589 1.4039708717557752e-07 6.852641902439092 0.5183497559872667 DLK(ub)YTIENPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLKYTIENPR 10 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 15710500.0 4259200.0 3645600.0 7805700.0 True False 5583852.446151472 3101690.690437502 6998041.041561521 1.0 0.5554750452933733 1.2532639622998532 22.41282938801749 -6.734635943740835 1.7065608289796343 0.7338683261292894 1.2531925781508606 0.5804717906082011 0.1868099621438361 0.32763828890510216 1.8714018240394326 0.08667913983205125 0.21394956724843475 1.842315713296955e-07 6.734635943740835 0.5193242520215712 DLK(ub)YTIENPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLKYTIENPR 10 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 17235800.0 3102800.0 3088000.0 11045000.0 True False 3004303.3123868476 4321054.503707266 8151983.1571024945 1.0 1.4382883665212522 2.7134354655508925 21.51859904302401 -6.952138748662183 0.5348557431620189 0.9805645417357023 3.22952831922339 0.9993585706669258 0.018406906169236376 0.08263826763661682 0.0324957625144956 0.02039164887589189 0.10551771074965988 1.116506488630534e-07 6.952138748662183 2.248963777487688 up DLK(ub)YTIENPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLKYTIENPR 10 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 33177600.0 3709600.0 11910000.0 17558000.0 True False 5627734.408086876 9784567.446745263 14087653.604055207 1.0 1.7386334779205552 2.5032548770979126 22.424122813823047 -6.970691201426116 0.24110679309201563 0.7291870100071873 3.534847199940727 0.9999872828831649 0.002188625462666464 0.0760790314254373 0.008223513037123617 0.01813502747592389 0.07439665255009377 1.069815284956689e-07 6.970691201426116 2.8056601899335396 DLK(ub)YTIENPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLKYTIENPR 10 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 25741400.0 4259200.0 6224200.0 15258000.0 True False 5833941.340552127 5949194.263323046 11654374.648373954 1.0 1.0197555847827589 1.9976845785821662 22.47603944954038 -6.911269528509596 0.8870550936977398 0.9709216732898759 2.1275534915994134 0.9913912995611125 0.04321153294322951 0.10358537908364301 0.1342630286887644 0.03560107936510205 0.09916006650175196 1.2266777035704184e-07 6.911269528509596 1.1566318183095374 DLK(ub)YTIENPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLKYTIENPR 10 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 17542000.0 3102800.0 4612700.0 9826500.0 True False 2580115.6773463935 4587850.46955074 11881175.717397448 1.0 1.7781568903411604 4.604900401061491 21.299004318458287 -6.947090072091483 0.5899263472868445 0.9673200259792016 5.557957075861445 0.9989526896863413 0.05012518268990953 0.08467570023848889 0.040963545293456825 0.05197054810254842 0.23680547992798207 1.1295616208164626e-07 6.947090072091483 4.590637049882243 DLKPQNLLIDDK(ub)GTIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLKPQNLLIDDKGTIK 16 2 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 31003200.0 8444400.0 12714000.0 9844800.0 True False 11070690.175685933 10817120.75878384 8826154.533989875 1.0 0.9770954282995836 0.79725422660408 23.400241830504545 -6.93044544086553 0.743124773613162 1.0026901378424034 0.7599112042408558 0.9966250891612648 0.005266804642088565 0.09240721839221226 0.07655141279309212 0.00481108505279388 0.01623285477446289 1.1736931208340186e-07 6.93044544086553 -0.24277893360154756 DLKPQNLLIDDK(ub)GTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLKPQNLLIDDKGTIK 16 2 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 35599200.0 9937800.0 8336400.0 17325000.0 True False 9622329.978676705 11665167.9937517 12787062.761140846 1.0 1.2123018041993954 1.3288946429271558 23.197954843950882 -12.960599907274833 0.07949247593509644 1.0570334252662002e-21 1.6988087752897587 0.9999095390887414 0.0012949467716720348 8.57384369062825 0.06965978162001557 1.693653803613584 0.3069687979119661 1.0949646352499738e-13 12.960599907274833 1.6988087752897587 DLKPQNLLIDDK(ub)GTIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLKPQNLLIDDKGTIK 16 2 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 177508000.0 17886000.0 30072000.0 129550000.0 True False 27134369.64175164 24705416.646391578 103944385.716218 1.0 0.9104842667278096 3.830727858747779 24.69361805804821 -6.899827223111604 0.9623467304317952 0.8780107978605224 4.136197071317843 0.9864805348949143 0.15766761090488426 0.11153298489917653 0.17813242549749514 0.12291685893414658 0.3195368657682048 1.2594263541206224e-07 6.899827223111604 3.258186273457321 up DLKPQNLLIDDK(ub)GTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLKPQNLLIDDKGTIK 16 2 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 35422400.0 8444400.0 9757000.0 17221000.0 True False 11566522.881329456 9325903.477915712 13153754.477627989 1.0 0.8062840988253673 1.1372263395476114 23.463451892027436 -6.748053495711526 1.6570842825855616 0.8858278442868289 1.1377865929647555 0.6405543097388843 0.08139392401619018 0.30344428823311864 1.63878496667041 0.03881223549517622 0.09441767001579147 1.7862675316736855e-07 6.748053495711526 0.25195874867792656 DLKPQNLLIDDK(ub)GTIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLKPQNLLIDDKGTIK 16 2 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 36914800.0 9937800.0 10767000.0 16210000.0 True False 8263721.019186879 10708996.03391782 19599436.05342825 1.0 1.2959048362176617 2.3717446423859028 22.978360119385158 -6.947070095278249 0.5901334315787379 0.9875698694950559 2.7342268454668157 0.9989508455335036 0.019091487437521613 0.08468400646647314 0.040998933393531195 0.019790118666037956 0.09013219540826967 1.1296135799397311e-07 6.947070095278249 1.7466569759717598 up DLKPQNLLIDDK(ub)GTIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLKPQNLLIDDKGTIK 16 2 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 218420000.0 17886000.0 19534000.0 181000000.0 True False 23153779.58576938 18446915.728233982 148059857.21683294 1.0 0.7967129366460627 6.394630158258589 24.464744380140658 -6.898470664571418 0.9708630084400571 0.7573925352025533 6.9643580034574 0.9857906379587144 0.30900966315596506 0.11254055065340493 0.18382668257525187 0.23937939434111807 0.6181952774713615 1.263366437943033e-07 6.898470664571418 6.206965468254847 up DLKPSNLAVNEDCELK(ub)ILDFGLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLKPSNLAVNEDCELKILDFGLAR 24 2 Q16539;B4E0K5;Q16539-5;Q16539-3;Q16539-4;Q16539-2;E7EX54 Q16539 MAPK14 Mitogen-activated protein kinase 14 1 48615000.0 7126000.0 15242000.0 26247000.0 True False 10810662.980382541 12521946.013710435 21059268.945531227 1.0 1.1582958451700194 1.9480090151497844 23.365951665469183 -6.939855829385347 0.6609108944083834 0.991113496323806 2.160064074553647 0.9981448648097858 0.017859585997097985 0.08783259579772514 0.05491120937811246 0.01736596408907784 0.06801237428916282 1.1485348317087578e-07 6.939855829385347 1.168950578229841 DLKPSNLAVNEDCELK(ub)ILDFGLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLKPSNLAVNEDCELKILDFGLAR 24 2 Q16539;B4E0K5;Q16539-5;Q16539-3;Q16539-4;Q16539-2;E7EX54 Q16539 MAPK14 Mitogen-activated protein kinase 14 1 49102300.0 7126000.0 9898300.0 32078000.0 True False 9224747.474460056 9347450.903695006 26240133.14807497 1.0 1.0133015488580768 2.8445367443091834 23.137077987561632 -6.908492573803343 0.9059396833988131 0.9405629457567312 3.073717791029218 0.9903401528621112 0.08515417820256527 0.1054232706631929 0.1442370885543785 0.06920136845429434 0.18908947441649213 1.234546425054727e-07 6.908492573803343 2.133154845272487 up DLLAAAK(ub)TGSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLLAAAKTGSGK 12 1 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 1 5942200.0 1541000.0 2244200.0 2157000.0 True False 2020265.9230652263 1909374.1078230836 1933814.3314050247 1.0 0.945110287721978 0.9572078157270337 20.946113773507744 -10.414819082738966 4.97362953855778 1.0000600217480171 0.9511590517245495 0.9560104427829273 0.004938795126922191 3.291094491701947e-06 3.872183548172995e-07 0.004787842643505225 0.001593989273072211 3.847520276605212e-11 10.414819082738966 -0.048900970023467605 DLLAAAK(ub)TGSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLLAAAKTGSGK 12 1 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 1 6964700.0 1853100.0 1607200.0 3504400.0 True False 1794274.3548356544 2248963.341437278 2586492.510253502 1.0 1.2534110713761333 1.4415256525752498 20.774969072791194 -6.974396007848853 0.11087482388070462 0.6101039113533275 2.0896366143740166 0.9999996048275716 0.00011357704697418104 0.07490021258563548 0.0032791571164295123 0.01477742415599071 0.028639506018226908 1.060727900085337e-07 6.974396007848853 1.479532703020689 DLLAAAK(ub)TGSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLLAAAKTGSGK 12 1 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 1 6379900.0 1853100.0 3042100.0 1484700.0 True False 1540934.7562493884 3025711.6034904313 1795143.9055228212 1.0 1.9635559462977958 1.1649707414557733 20.55537434822547 -10.134852876949664 4.27105171579286 0.9999154147270173 1.5642633429426713 0.3996414848057047 0.32602104528015685 151814625.2638598 147089893.5787169 199696.7218716627 0.11931148346934338 7.33072829281687e-11 10.134852876949664 0.564347928215654 DLLAAAK(ub)TGSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLLAAAKTGSGK 12 1 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 1 20350500.0 4172800.0 3874700.0 12303000.0 True False 5401771.858185087 3659069.5388649637 10063980.23944031 1.0 0.677383205905026 1.8630887241546061 22.36500127877205 -6.834227056908108 1.3090082944016386 0.8280577245874287 1.8978182724695543 0.9140497815427265 0.14674591062759895 0.17565368918845375 0.5871462129092275 0.0879809522474714 0.20247556467974415 1.4647818266423172e-07 6.834227056908108 1.0697605478821255 DLLAVVFYGTEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLLAVVFYGTEK 12 0 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 5066300.0 2516900.0 1179900.0 1369500.0 False True 2092913.8675754652 1173543.6445081865 1655856.1181474407 1.0 0.560722379783205 0.7911726057153351 20.99708150902163 -10.013077282924899 4.988401717458797 1.0000038676610707 0.6759474927458057 0.7250045529397027 0.09408091078581209 4.046841752806882e-06 8.00569203155944e-07 0.09109453726083312 0.03036448338740542 9.703372798664271e-11 10.013077282924899 -0.32405637491526507 DLLDLLVEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLLDLLVEAK 10 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 31792700.0 5373700.0 15933000.0 10486000.0 False True 8152295.770092862 13089631.664902791 8413437.503822934 1.0 1.6056374834832188 1.0320329071827945 22.95877496360336 -10.221817169117877 4.869213895960052 0.9999481883290277 1.3188351953335795 0.2917603492432421 0.23417308767887393 0.00013173332271986185 2.10528836466307e-05 0.22677388239751703 0.07557903905890558 6.000436316573748e-11 10.221817169117877 0.31888700700455186 DLLDLLVEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLLDLLVEAK 10 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 13025400.0 5373700.0 0.0 7651700.0 False True 6956360.581463101 0.0 6259169.113072061 1.0 0.0 0.8997764045974163 22.72990128569581 -9.171402662423617 12.17453633584643 1.0000114935176068 0.44990304515746476 0.33261809882871307 0.367332179236474 0.0 0.0 0.355667853421152 0.11855595114038396 6.739029190943769e-10 9.171402662423617 -0.5501084483601419 DLLEEGK(ub)ATVPCLAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLLEEGKATVPCLAEK 16 1 F8W8T1;P20591;P20591-2 F8W8T1 MX1 Interferon-induced GTP-binding protein Mx1;Interferon-induced GTP-binding protein Mx1, N-terminally processed 1 18991900.0 4932100.0 4797800.0 9262000.0 True False 7482356.28480842 3941595.104617503 7431361.640321179 1.0 0.526785273860883 0.9931846810621975 22.835061233166446 -10.923495586854562 10.634913319828371 1.0368655419446158 0.7599849774615403 0.26095716147438675 0.19040676066329576 0.10588651064720991 0.000761715126503356 0.117292362570608 0.0614535177545205 1.1926263848376806e-11 10.923495586854562 -0.2768805644830755 DLLEEGK(ub)ATVPCLAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLLEEGKATVPCLAEK 16 1 F8W8T1;P20591;P20591-2 F8W8T1 MX1 Interferon-induced GTP-binding protein Mx1;Interferon-induced GTP-binding protein Mx1, N-terminally processed 1 18548600.0 4932100.0 4468600.0 9147900.0 True False 6384700.676225723 4219918.481784904 7483076.065380476 1.0 0.6609422580291554 1.1720324013378889 22.606187555258895 -6.727863660487652 1.7311392674502097 0.7954675072602589 1.1716035653588575 0.5492390430796368 0.14255781184905608 0.3402785877602791 1.9968299653878234 0.06528656101571423 0.16239008531953406 1.871269502028476e-07 6.727863660487652 0.3761360580985985 DLLFILTAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLLFILTAK 9 0 Q16531;F5GY55;F5H2L3;F5GYG8;F5GWI0;F5GZY8 Q16531;F5GZY8 DDB1 DNA damage-binding protein 1 0 38752900.0 8907900.0 12736000.0 17109000.0 False True 13513935.554722097 10463161.293177808 13727398.650858907 1.0 0.7742497550627823 1.0157957757954692 23.68794454453388 -11.065640943136609 11.733798363330324 1.618461570656926 0.8950227654291257 0.2011775364151016 0.09861075003246825 0.04079791101827662 0.0002282310845799334 0.00244158348500192 0.03182648271939768 8.597240123111138e-12 11.065640943136609 -0.7234388052278004 DLLFILTAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLLFILTAK 9 0 Q16531;F5GY55;F5H2L3;F5GYG8;F5GWI0;F5GZY8 Q16531;F5GZY8 DDB1 DNA damage-binding protein 1 0 3508770.0 1770800.0 604970.0 1133000.0 False True 1472498.6597412028 601710.9065328569 1369905.0615998886 1.0 0.4086325665237684 0.9303268648411908 20.489834890248773 -10.393761394987102 8.60367782031402 1.0000020105574068 0.6694797156824833 0.348612111013457 0.21298080543283224 8.214060649220714e-06 5.786052661083111e-07 0.206219034612252 0.06873925937526681 4.038672200464944e-11 10.393761394987102 -0.33052229487492346 DLLFILTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLLFILTAK 9 0 Q16531;F5GY55;F5H2L3;F5GYG8;F5GWI0;F5GZY8 Q16531;F5GZY8 DDB1 DNA damage-binding protein 1 0 25453100.0 8907900.0 9616200.0 6929000.0 False True 11531452.15096025 9081050.016680833 5667993.0975438515 1.0 0.7875027271326477 0.4915246599771795 23.45907086662633 -6.9664596284996705 0.33205084712744176 1.0352080638383963 0.23410032446253706 0.9999401459488292 0.0016131716925965741 0.07746910186103946 0.013132278977098519 0.004287798554541362 0.02577363365537504 1.080290038696139e-07 6.9664596284996705 -0.8011077393758592 down DLLFQALGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLLFQALGR 9 0 Q9NSD9 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 25420400.0 7048900.0 9285200.0 9086300.0 False True 9241176.161644703 7899884.35342613 8146136.83794412 1.0 0.8548570241756049 0.8815043340212992 23.139645050249655 -10.30784789097849 7.332159277425517 1.000001109196879 0.8681806790984611 0.9702628467411452 0.010878718689965563 1.9725440165693138e-07 1.862422338031255e-08 0.010533362756819934 0.0035110913595260023 4.92211899742555e-11 10.30784789097849 -0.13182043009841793 DLLFQALGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLLFQALGR 9 0 Q9NSD9 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 19086600.0 7562600.0 2511200.0 9012800.0 False True 7322529.40255794 3513935.255734998 6652077.301795681 1.0 0.479879978973863 0.9084398212825129 22.803910650373762 -10.037412551146371 7.2146229925334495 1.0000000347367264 0.6941599001281894 0.4044267236915443 0.1749588229839693 9.757793926414982e-08 1.3295713435404718e-08 0.16940316959231097 0.056467717307413685 9.174606552258632e-11 10.037412551146371 -0.305840134608537 DLLFQALGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLLFQALGR 9 0 Q9NSD9 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 26645200.0 7048900.0 8978300.0 10618000.0 False True 9655068.819359949 8581609.018732252 8110247.084574288 1.0 0.8888190420274126 0.8399988893203901 23.202855111772546 -13.999999989145754 0.111785205700259 1.5348806744147339 0.7526986226824088 0.9997339992223032 0.0010919652508947209 12.002424138597881 0.10174391811582022 1.4442723221257523 0.07750988248073418 1.0000000249928242e-14 13.999999989145754 -0.782182051732325 DLLFQALGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLLFQALGR 9 0 Q9NSD9 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 14114600.0 7562600.0 3202000.0 3350000.0 False True 6288636.979985767 3184750.190452766 4050469.5113500655 1.0 0.5064293265120186 0.644093390068643 22.58431592580804 -10.481973551916282 9.258366834029808 1.000006792707092 0.5752613582903471 0.9269663728980106 0.056201118605300505 7.880058945812013e-06 4.4099095344305646e-07 0.05441736802570732 0.018138833033046402 3.2962978567844726e-11 10.481973551916282 -0.42474543441674484 DLLHPSLEEEK(ub)KK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLLHPSLEEEKKK 13 2 H0YMV8;Q71UM5;C9JLI6 H0YMV8 RPS27L 40S ribosomal protein S27;40S ribosomal protein S27-like 1 4182350.0 1771900.0 1486800.0 923650.0 True False 2322978.059104009 1264975.2355010088 828079.558276426 1.0 0.5445489381802081 0.3564732585532137 21.1475440970519 -13.999999999999984 0.12145741833989367 3.168630010745401 0.06210422953590189 0.9996858214496087 0.00478881245557087 11.958406287618 0.10744186449668164 6.247959252897491 0.2612526935579124 1.0000000000000368e-14 13.999999999999984 -3.106525781209499 DLLHPSLEEEK(ub)KK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLLHPSLEEEKKK 13 2 H0YMV8;Q71UM5;C9JLI6 H0YMV8 RPS27L 40S ribosomal protein S27;40S ribosomal protein S27-like 1 6719540.0 1582300.0 988340.0 4148900.0 True False 1532070.7526072308 1382989.3161250132 3062178.6256679473 1.0 0.9026928513395903 1.9987188062018846 20.5470514932702 -6.885252305365526 1.0501097610372312 0.9342331849801521 2.0846484707365454 0.9776794696359751 0.07400282798244476 0.12307769584620049 0.24505323592346873 0.05400455237769293 0.13252140197279552 1.3024099176244353e-07 6.885252305365526 1.1504152857563934 DLLHPSLEEEK(ub)KK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLLHPSLEEEKKK 13 2 H0YMV8;Q71UM5;C9JLI6 H0YMV8 RPS27L 40S ribosomal protein S27;40S ribosomal protein S27-like 1 7832400.0 1582300.0 1763800.0 4486300.0 True False 1315752.5577753012 1754298.0593131105 5424364.5876924805 1.0 1.3333039323741163 4.12263275160498 20.327456768704476 -6.929267258067938 0.752784137168162 0.9564098172369676 4.68472386911543 0.9963922504080458 0.08409580228431697 0.09302003369102181 0.07955762221047638 0.0762840949114336 0.2534105900285066 1.176881516057253e-07 6.929267258067938 3.7283140518784625 up DLLHPSPEEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLLHPSPEEEK 11 0 P42677 P42677 RPS27 40S ribosomal protein S27 0 16089200.0 5021200.0 2136600.0 8931400.0 False True 4861804.754465918 2989755.5222218097 6591998.403743339 1.0 0.6149476733872342 1.3558747701022162 22.21306052656994 -6.765477677198848 1.5916950866683928 0.7778626694716082 1.3593519781956915 0.71292836660043 0.16210903180113187 0.273838710588775 1.3684205610563411 0.08031094326152764 0.1919828297752769 1.7160199115336185e-07 6.765477677198848 0.5814893087240833 DLLHPSPEEEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLLHPSPEEEKR 12 1 P42677 P42677 RPS27 40S ribosomal protein S27 1 15344400.0 3351000.0 4282700.0 7710700.0 True False 4393193.451130166 3643737.8538338477 6912870.730257177 1.0 0.8294052821408268 1.5735411625178524 22.06683859819743 -6.84639723391665 1.252296883173243 0.9091706662965471 1.6012931859883937 0.9349060809477873 0.08120755248826514 0.16146321401823413 0.4890785316888024 0.05078561143689764 0.11728568141903276 1.4243042365407446e-07 6.84639723391665 0.6921225196918466 DLLHPSPEEEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLLHPSPEEEKR 12 1 P42677 P42677 RPS27 40S ribosomal protein S27 1 31885500.0 0.0 6145500.0 25740000.0 True False 0.0 8599430.198359132 18997921.816552088 0.0 DLLHPSPEEEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLLHPSPEEEKR 12 1 P42677 P42677 RPS27 40S ribosomal protein S27 1 234648200.0 8943200.0 18195000.0 207510000.0 True False 13567488.235497765 14947960.091816124 166495557.54513592 1.0 1.1017485206072641 12.271656673305198 23.693650321917357 -6.908892664796021 0.9032245222982613 0.6419284700688617 13.681590846968009 0.9904973725653 0.5156465615515694 0.1051553111635024 0.1427660198475121 0.4198687973362786 1.1503518460147808 1.2334096308291568e-07 6.908892664796021 13.039662376899146 up DLLHPSPEEEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLLHPSPEEEKR 12 1 P42677 P42677 RPS27 40S ribosomal protein S27 1 12084000.0 3351000.0 3355400.0 5377600.0 True False 4589955.257369975 3207147.333176017 4107521.635148493 1.0 0.6987317203204502 0.8948936111203154 22.130048659720323 -10.489580427393628 6.379898165478153 1.0001125827201869 0.7968126657203828 0.5885703096739572 0.08008275657320396 0.00012831151873217786 1.0265426446685687e-05 0.07758254689832801 0.025846598543866804 3.239064323507713e-11 10.489580427393628 -0.2032999169998041 DLLHPSPEEEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLLHPSPEEEKR 12 1 P42677 P42677 RPS27 40S ribosomal protein S27 1 33798100.0 0.0 9772100.0 24026000.0 True False 0.0 9719455.757690027 29049725.51632741 0.0 DLLHPSPEEEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLLHPSPEEEKR 12 1 P42677 P42677 RPS27 40S ribosomal protein S27 1 300905200.0 8943200.0 15152000.0 276810000.0 True False 11577148.696827268 14308777.88032154 226433420.3104505 1.0 1.235950081926725 19.558651809707243 23.464776644009806 -6.909709491886073 0.8977210283317326 0.42746820397739727 21.91181758877994 0.9908112399005296 0.8333466925778769 0.10461017551289867 0.13981541561486296 0.681293720335533 1.876890562653895 1.23109199707648e-07 6.909709491886073 21.48434938480254 up DLLHPSPEEEKRK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLLHPSPEEEKRK 13 2 P42677 P42677 RPS27 40S ribosomal protein S27 1 5699100.0 1227000.0 2045200.0 2426900.0 True False 1608608.8822849027 1740064.1321271611 2175787.668468638 1.0 1.0817198333851896 1.3525896148093515 20.617382160655865 -6.949190585500701 0.5676693577970935 0.9965895177962582 1.450836601100693 0.9991361555089174 0.004428968735081338 0.08381257913329473 0.03732148678666681 0.004704792075693799 0.022555996519012265 1.1241115613427773e-07 6.949190585500701 0.45424708330443486 DLLHPSPEEEKRK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLLHPSPEEEKRK 13 2 P42677 P42677 RPS27 40S ribosomal protein S27 1 312608600.0 9576600.0 17732000.0 285300000.0 True False 14528402.34324045 14567586.05925166 228910329.9485679 1.0 1.0026970423234074 15.756056622087684 23.79237272587372 -6.906931228323875 0.9163571513831883 0.49769893196678294 17.542774542648626 0.9897115951576513 0.7055022338062855 0.10648312397159013 0.1500251858199522 0.5689794432407647 1.5392120783812089 1.2389927687682215e-07 6.906931228323875 17.04507561068184 up DLLHPSPEEEKRK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLLHPSPEEEKRK 13 2 P42677 P42677 RPS27 40S ribosomal protein S27 1 430032600.0 9576600.0 13116000.0 407340000.0 True False 12397097.483007882 12386083.070109388 333208299.66135263 1.0 0.9991115329282849 26.877928492380217 23.563499047966168 -6.906883850506945 0.9166890586724847 0.11770232136889935 30.00871813182791 0.9896920443877396 1.2385597911568618 0.10651394971046375 0.1502083445045303 0.9986626909767705 2.7007394662971604 1.2391279396649614e-07 6.906883850506945 29.89101581045901 up DLLIAYYDVDYEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLLIAYYDVDYEK 13 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 11086400.0 3004300.0 4018900.0 4063200.0 False True 3889125.573606556 3795244.68210297 3323739.2919526836 1.0 0.9758606684904426 0.8546238040008657 21.891014387149692 -6.939709255489143 0.6622982493628438 1.0013679367492452 0.8222116656656797 0.9981250942794234 0.002754289542839138 0.08790035654702343 0.05522314332355486 0.0026751570670272844 0.010448113270691116 1.1489225263343692e-07 6.939709255489143 -0.17915627108356547 DLLK(ub)ANVEKPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLLKANVEKPVK 12 2 Q9H8Y8-3;Q9H8Y8 Q9H8Y8-3 GORASP2 Golgi reassembly-stacking protein 2 1 10669000.0 2186900.0 2704100.0 5778000.0 True False 2117478.0565485386 3783861.2316952157 4264568.463715539 1.0 1.7869659711434553 2.0139847260881325 21.013915588292445 -10.794381408259706 0.24895084394182443 4.458437602963391e-11 2.1280280594371304 0.9992046825012055 0.01225315573937574 2.611278811816236 0.12895196593686928 1.6511401618128514 0.10417525358931432 1.6055306165928368e-11 10.794381408259706 2.128028059392546 DLLK(ub)ANVEKPVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLLKANVEKPVK 12 2 Q9H8Y8-3;Q9H8Y8 Q9H8Y8-3 GORASP2 Golgi reassembly-stacking protein 2 1 30718600.0 4437700.0 7814900.0 18466000.0 True False 6732315.339326925 6420270.036907604 14816187.006064666 1.0 0.9536496306706694 2.2007565390640096 22.682671322912476 -6.898268088747094 0.9721615443730335 0.9456572476839759 2.3271487415826186 0.9856845011313695 0.0690697073876471 0.11269102668584619 0.18470107443511974 0.05345538342770447 0.13791035144792402 1.2639558702429635e-07 6.898268088747094 1.381491493898643 up DLLK(ub)ANVEKPVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLLKANVEKPVK 12 2 Q9H8Y8-3;Q9H8Y8 Q9H8Y8-3 GORASP2 Golgi reassembly-stacking protein 2 1 23059200.0 4437700.0 5752500.0 12869000.0 True False 5744690.130144743 5432368.318146095 10526974.04709075 1.0 0.9456329575794231 1.8324703001562093 22.453797645004926 -6.8923135006965435 1.008613960210469 0.9549581634337414 1.912290584560438 0.9823376290438534 0.05393767879359948 0.11728546284254084 0.21105209403239186 0.04061862779626772 0.1021420295172787 1.2814052509189525e-07 6.8923135006965435 0.9573324211266967 DLLLK(ub)CLTFNPAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLLLKCLTFNPAK 13 1 Q00534 Q00534 CDK6 Cyclin-dependent kinase 6 1 5183700.0 1522700.0 2143000.0 1518000.0 True False 1996274.4458477742 1823272.7533485745 1360931.9216842013 1.0 0.9133377212441701 0.681735882816575 20.928878643929956 -6.954016781297921 0.512854378054239 1.0041643570877457 0.5806989512778593 0.9994799675104339 0.0030636709866957513 0.0819117896606764 0.029589066824486174 0.0035116093641108137 0.019118534998675826 1.1116887703902138e-07 6.954016781297921 -0.42346540580988634 DLLLK(ub)CLTFNPAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLLLKCLTFNPAK 13 1 Q00534 Q00534 CDK6 Cyclin-dependent kinase 6 1 7881500.0 1522700.0 2239300.0 4119500.0 True False 2085683.3394202471 2140360.3216251535 3146558.9437656594 1.0 1.026215380432633 1.5086465353078486 20.992088705452847 -6.918120543331883 0.8385337421063741 0.9886177415904613 1.583180027936972 0.9936431106857442 0.018644428340376606 0.0992901639998729 0.11143249411239751 0.015906279621720504 0.04682445166227731 1.2074786392746942e-07 6.918120543331883 0.5945622863465108 DLLLNTMSQEEK(ub)AAYLSDPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLLLNTMSQEEKAAYLSDPR 20 1 P78527 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 7621100.0 1654800.0 3599600.0 2366700.0 True False 2169458.8251059945 3062553.7111309017 2121816.5869894624 1.0 1.4116671290045215 0.9780395748630055 21.048903774340733 -6.657953126955183 1.9805103479127473 1.2654332437925928 0.9798652397143285 0.22684938558184198 0.17536510392919025 0.4892771846931415 3.6872158896609197 0.07159773372174791 0.1943168048611566 2.198097098787603e-07 6.657953126955183 -0.2855680040782643 DLLLNTMSQEEK(ub)AAYLSDPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLLLNTMSQEEKAAYLSDPR 20 1 P78527 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 14081200.0 4693400.0 2736100.0 6651700.0 True False 4544410.58603727 3828638.9985730057 4909420.223277376 1.0 0.8424940762035286 1.0803205675036496 22.115661757089235 -6.7281204840736075 1.7300096749212568 0.9050170448188226 1.080133425192608 0.5505835870862982 0.06622199698690455 0.3397626514290589 1.9912844902054463 0.03034457066797885 0.07546087574807914 1.8701632386690349e-07 6.7281204840736075 0.1751163803737854 DLLLNTMSQEEK(ub)AAYLSDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLLLNTMSQEEKAAYLSDPR 20 1 P78527 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 66433600.0 7464600.0 13720000.0 45249000.0 True False 11324343.935358346 11271558.805150738 36305515.31665872 1.0 0.9953387913234607 3.205970740901016 23.432924135796796 -6.906422354377213 0.9197522673535321 0.9235717524074972 3.4708318327486727 0.9895000254548693 0.10667113797576139 0.10683166624726022 0.1519514829870612 0.0858167713706604 0.23141344609188078 1.2404453791328994e-07 6.906422354377213 2.5472600803411756 up DLLLNTMSQEEK(ub)AAYLSDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLLLNTMSQEEKAAYLSDPR 20 1 P78527 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 8936600.0 1654800.0 2923700.0 4358100.0 True False 2266624.279288518 2794521.26661701 3328806.537886912 1.0 1.232900085008441 1.4686185832844816 21.112113835863624 -6.970975653872665 0.23371309495169712 0.9084781763337678 1.7998059347099067 0.9999890231252946 0.000633822769231959 0.07598738938742905 0.007888381656538537 0.005894380677022589 0.02324603072544647 1.0691148110819151e-07 6.970975653872665 0.8913277583761389 DLLLNTMSQEEK(ub)AAYLSDPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLLLNTMSQEEKAAYLSDPR 20 1 P78527 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 14056200.0 4693400.0 5337400.0 4025400.0 True False 3902770.0528740403 5308646.366809055 4867092.528653303 1.0 1.3602252489612379 1.2470866750320393 21.89606703252351 -10.102161045727314 4.299998575173364 0.9999613075897811 1.303655962005426 0.9057016275484373 0.046188629541296995 16079078.472019238 0.531769832750033 6662.185495851118 0.01581159641506001 7.903854817279133e-11 10.102161045727314 0.3036946544156449 DLLLNTMSQEEK(ub)AAYLSDPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLLLNTMSQEEKAAYLSDPR 20 1 P78527 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 55021400.0 7464600.0 8049800.0 39507000.0 True False 9663071.849263905 7601821.553657089 32317131.3760521 1.0 0.7866878847885382 3.3443952275397697 23.204050457889245 -6.886655499762459 1.0419896375839557 0.8513511879873666 3.5504706081632316 0.9786688909651917 0.16923215173943928 0.12189764148018693 0.23804792385825424 0.12426318693745604 0.3062784211804515 1.2982086551316149e-07 6.886655499762459 2.699119420175865 up DLLNMYIETEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLLNMYIETEGK 12 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 3836900.0 1144100.0 1668500.0 1024300.0 False True 1499926.1794801604 1419566.3037620601 918315.261779399 1.0 0.9464241128547065 0.6122403051179931 20.516460067966253 -6.935018698955519 0.7043795164795386 1.0042613562101357 0.5339555871667527 0.9974359198721634 0.008687423193855097 0.09011441838107806 0.06551936695214255 0.008165927716306694 0.02944831817067893 1.1613986076594278e-07 6.935018698955519 -0.47030576904338295 DLLPYGFAIHHAGMTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLLPYGFAIHHAGMTR 16 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 12100300.0 4318200.0 4370600.0 3411500.0 False True 5661202.0175082795 3718523.516465368 3058510.7054187437 1.0 0.6568434592097525 0.540258181205997 22.432676975841343 -13.999999999999998 0.15071617692848022 2.6611611819754963 0.4130414029483827 0.9995638662633071 0.004075230919093426 11.960508532385989 0.12230258227299227 5.817421931834272 0.1147463455501215 1.0000000000000041e-14 13.999999999999998 -2.2481197790271135 DLLPYGFAIHHAGMTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLLPYGFAIHHAGMTR 16 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 12441100.0 3631700.0 3191900.0 5617500.0 False True 5509554.412834022 2622280.50657147 4507198.662762284 1.0 0.47595146722992665 0.8180695433850624 22.39350421436577 -9.876241162031 5.401432789972986 1.0000003005065516 0.6470105053044869 0.5866774270920295 0.13966911973769527 5.055089698084787e-07 1.0502103936738275e-07 0.13523415954519105 0.04507801455876526 1.329715826919128e-10 9.876241162031 -0.35298979520206475 DLLPYGFAIHHAGMTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLLPYGFAIHHAGMTR 16 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 12916500.0 4318200.0 2822600.0 5775700.0 False True 5914755.23496717 2697888.1989099984 4411598.614275362 1.0 0.4561284603901235 0.7458632587523883 22.495887037364234 -10.060907886623468 5.232837591382733 1.000004862514279 0.6009958595704961 0.7166071379053418 0.11828373612196283 6.710077666737416e-06 1.2041090061465412e-06 0.11452913063184507 0.0381759116769107 8.691447543736624e-11 10.060907886623468 -0.39900900294378294 DLLPYGFAIHHAGMTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLLPYGFAIHHAGMTR 16 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 9303300.0 3580500.0 1958300.0 3764500.0 False True 2977344.393044593 1947750.249207882 4551639.5449186135 1.0 0.6541904435906182 1.5287581629964437 21.5055946788412 -6.7994315035835164 1.4581279498259712 0.8090539725675043 1.5406727001290916 0.8304838037709227 0.1480702976893955 0.22159601276653818 0.9301954729647889 0.07988693878439465 0.18586094476394524 1.5869691941351093e-07 6.7994315035835164 0.7316187275615873 DLLPYGFAIHHAGMTR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DLLPYGFAIHHAGMTR 16 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 65871600.0 14562700.0 28205800.0 23103100.0 False True 18851702.223732755 26636122.43510909 18898572.857824408 1.0 1.4129293004414416 1.0024862812670914 24.168191462446114 -9.85280810924085 12.323396333900504 1.0000001577863094 1.2077077908452547 0.2545430005176462 0.1675626609107798 0.0 0.0 0.16224184878840148 0.05408061626280049 1.4034336674583983e-10 9.85280810924085 0.20770763305894535 DLLQFFK(ub)PR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLLQFFKPR 9 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 9820800.0 3351300.0 3711200.0 2758300.0 True False 4393586.754035364 3157503.4261442944 2472897.575481909 1.0 0.718661904933192 0.5628425507270647 22.0669677504325 -13.999999999999972 0.0704994063394034 2.621707089588359 0.003110968628701076 0.99992271069785 0.0015903980099653539 12.35512985411709 0.0718280699845714 3.2853370863740925 0.5151577152130673 1.0000000000000655e-14 13.999999999999972 -2.618596120959658 DLLQFFK(ub)PR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLLQFFKPR 9 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 15463700.0 4768100.0 6019100.0 4676500.0 True False 4616739.275425986 8422558.019191839 3451584.358007225 1.0 1.8243521058300807 0.7476238427366569 22.138442829614647 -6.702123773259872 1.823175643625319 1.5108245028214962 0.7506878264248361 0.4276682929386918 0.34783693470391636 0.39114852966894403 2.5291284458377334 0.15211654048766057 0.390198720097799 1.9855289640101145e-07 6.702123773259872 -0.76013667639666 DLLQFFK(ub)PR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLLQFFKPR 9 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 10564800.0 3351300.0 3531500.0 3682000.0 True False 4590366.175477164 3375466.6528911837 2812387.433170328 1.0 0.735337122106671 0.61267169669269 22.13017781195539 -13.999999999990688 0.10298759006711984 2.2963768748935154 0.3630993011564989 0.999778673207578 0.0024045621458489027 12.058388039394703 0.09616240055064275 3.2983201434851392 0.22223686265024883 1.000000000021441e-14 13.999999999990688 -1.9332775737370165 DLLQFFK(ub)PR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLLQFFKPR 9 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 11868200.0 4768100.0 5041700.0 2058400.0 True False 3964886.412645146 5014539.3614008995 2488801.923033725 1.0 1.2647372054362296 0.6277107750416836 21.918848105048923 -6.793845667540491 1.4810426847333136 1.147224794620364 0.620209648645947 0.8135148154213248 0.11283855582708172 0.229664235285114 0.995087947895979 0.059958290119262965 0.13998744864049129 1.6075124029516346e-07 6.793845667540491 -0.527015145974417 DLLQFFKPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLLQFFKPR 9 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 38278800.0 8739100.0 9948700.0 19591000.0 False True 11457044.729564784 8464392.73972887 17563911.25014176 1.0 0.738793723820122 1.533022840071338 23.449731622457126 -6.818087014890969 1.3800203804170368 0.8589290213314352 1.5496759090292958 0.8799459162588686 0.11451841503230988 0.19598216213480074 0.7338898122840944 0.06521691192059251 0.15040464050456964 1.5202429045780895e-07 6.818087014890969 0.6907468876978605 DLLQFFKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLLQFFKPR 9 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 42575000.0 11736800.0 5456900.0 25381300.0 False True 11364221.708399514 7635868.627357569 18733176.107321452 1.0 0.6719218282862038 1.6484345860196834 23.437995547145924 -6.816077837295683 1.3886265580519728 0.822437298632728 1.6680365073706016 0.8751640704997777 0.14335925460232146 0.19861905114740225 0.7535726056355633 0.08114636255496702 0.18726476804001613 1.5272923016941782e-07 6.816077837295683 0.8455992087378736 DLLQFFKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLLQFFKPR 9 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 40494800.0 8739100.0 12205100.0 19550600.0 False True 11970181.435297497 11665838.32513161 14933150.93724602 1.0 0.9745748958099796 1.247529205631868 23.512941683980017 -6.884105739515041 1.05667863327947 0.9831952057252925 1.268459780712888 0.9768474081464991 0.018733523258987833 0.1240535109019765 0.2508584824834429 0.01360279938127271 0.03326524411280312 1.3058529078907704e-07 6.884105739515041 0.2852645749875954 DLLQFFKPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLLQFFKPR 9 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 23761100.0 11736800.0 5287800.0 6736500.0 False True 9759669.228399899 5259313.571853879 8145071.003943204 1.0 0.538882358487076 0.834564247345767 23.2184008225802 -10.60853945555557 6.498797488425636 1.0008951695240633 0.6867233029164221 0.5994772242845854 0.12071162564768653 0.0015698220659927649 9.455959513576104e-05 0.11719144997441666 0.03895950965225949 2.4629780670695423e-11 10.60853945555557 -0.3141718666076412 DLLQFFKPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLLQFFKPR 9 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 17998400.0 5112900.0 5620800.0 7264700.0 False True 6618749.840326526 5307997.538919706 5942599.14211672 1.0 0.8019637646038974 0.8978431403933451 22.658127313624973 -10.097960482948091 4.49365207065942 1.0000129346477138 0.8499034524919571 0.765676608955803 0.0391425912801669 54482248.35581655 0.3980988464210005 7481.469467689919 0.013399550123608066 7.980673012051014e-11 10.097960482948091 -0.1501094821557567 DLLQIIFSFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLLQIIFSFSK 11 0 P42704;B8ZZ38;A0A0C4DG06;C9JCA9 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 936990000.0 306720000.0 341990000.0 288280000.0 False True 465316664.23560625 280959212.519934 231301331.64238766 1.0 0.6038021719713748 0.4970837053995376 28.793637613891395 -13.999999999999972 0.18409609361932888 3.0823516363301584 0.4158024422286958 0.9994937658533121 0.004867913490513753 12.260499014920818 0.1360461368958476 9.141735372986187 0.07699044464331786 1.0000000000000655e-14 13.999999999999972 -2.6665491941014627 DLLQIIFSFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLLQIIFSFSK 11 0 P42704;B8ZZ38;A0A0C4DG06;C9JCA9 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 488881000.0 306720000.0 17771000.0 164390000.0 False True 397055086.355092 16782028.228035532 134472706.78384092 1.0 0.042266246686554536 0.33867518992964135 28.564763935983844 -10.344206657631036 5.720864408865229 1.0001433929403962 0.19047071830809487 0.9086372271758505 0.12100844435720322 0.0002213511810913937 2.5374146657109723e-05 0.11718625160566229 0.03905530747882438 4.526821213149963e-11 10.344206657631036 -0.8096726746323013 DLMACAQTGSGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 DLMACAQTGSGK 12 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-3;C9J081;D6RCM4;H0Y960;Q9NQI0-3;Q9NQI0-2;Q9NQI0-4;Q9NQI0;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y;DDX4 ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y;Probable ATP-dependent RNA helicase DDX4 0 15666400.0 4648610.0 4784590.0 6233200.0 False True 6094372.727203271 4070747.8221857497 5588248.257076396 1.0 0.6679518966759734 0.9169521634494552 22.539046306178864 -9.800547624358506 6.564418345807654 1.000000002775948 0.7924520300626786 0.4808841019597938 0.10165393323544812 4.115402362839151e-09 8.937039713937837e-10 0.09842599909094749 0.03280866587476198 1.5828959781803822e-10 9.800547624358506 -0.2075479727132693 DLMACAQTGSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLMACAQTGSGK 12 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-3;C9J081;D6RCM4;H0Y960;Q9NQI0-3;Q9NQI0-2;Q9NQI0-4;Q9NQI0;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y;DDX4 ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y;Probable ATP-dependent RNA helicase DDX4 0 5417990.0 1867900.0 707690.0 2842400.0 False True 1808604.536936768 990274.3075545974 2097890.1698278063 1.0 0.5475350123979144 1.15994963353404 20.78644555717777 -6.70874801507266 1.799606360700126 0.7214944157873219 1.1584678583183854 0.45932419937824154 0.19070150222918142 0.3775226227437292 2.3825276242591458 0.0843533479728755 0.21462804250598547 1.9554737252673524e-07 6.70874801507266 0.4369734425310635 DLMACAQTGSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DLMACAQTGSGK 12 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-3;C9J081;D6RCM4;H0Y960;Q9NQI0-3;Q9NQI0-2;Q9NQI0-4;Q9NQI0;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y;DDX4 ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y;Probable ATP-dependent RNA helicase DDX4 0 14138940.0 4648610.0 3223110.0 6267220.0 False True 6367326.740961683 3080702.3428005427 4787031.713447511 1.0 0.48382978730808024 0.7518118526338585 22.602256367701756 -10.081770785517863 5.046443640168699 1.0000088812689087 0.6178208199695667 0.7305905948895888 0.10940322004909574 1.0932142590471795e-05 1.989112925808031e-06 0.10593167359930887 0.03530973743860312 8.283792552058908e-11 10.081770785517863 -0.382188061299342 DLMSK(ub)AEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLMSKAEK 8 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 6026500.0 1189500.0 1391700.0 3445300.0 True False 1151739.9735993817 1947413.0676196248 2542872.5732154967 1.0 1.6908443852422959 2.2078530150070166 20.135383608029127 -6.9776229781670445 0.11533798316645007 5.726203938293884e-08 3.910233465984915 0.9999995407130499 0.0003352820204714912 0.07454681290774041 0.003413794532559078 0.038412489155542205 0.07631680707597166 1.0528755045849633e-07 6.9776229781670445 3.9102334087228754 DLMSK(ub)AEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLMSKAEK 8 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 5157500.0 1189500.0 1855700.0 2112300.0 True False 989121.9537848203 1845702.9757723904 2553972.163828283 1.0 1.866001425516753 2.5820599310890335 19.915788883463403 -6.973305842978057 0.16065713195062215 0.2817805462104036 4.1852913619080505 0.9999980280503487 0.0009083132738137934 0.07524382341483334 0.004962618750311981 0.032935217886399866 0.0857201752839818 1.0633938811509096e-07 6.973305842978057 3.903510815697647 DLMSK(ub)AEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLMSKAEK 8 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 29366300.0 2999900.0 3400400.0 22966000.0 True False 3883429.6868695943 3211164.7508081724 18786423.65105962 1.0 0.8268888610666902 4.837585630706559 21.888899914175365 -6.896809923341629 0.9811843399356697 0.8183434308399364 5.23237752810643 0.9849122091295034 0.227388190268161 0.11379280320052179 0.19094443906853487 0.17479747352258931 0.44794813644092113 1.268206797538111e-07 6.896809923341629 4.4140340972664935 up DLNPFTPLVGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLNPFTPLVGIR 12 0 Q86U90 Q86U90 YRDC YrdC domain-containing protein, mitochondrial 0 1954990.0 420440.0 514750.0 1019800.0 False True 551200.9115467514 437951.3064797851 914280.8786123509 1.0 0.7945402435036417 1.6587071237722437 19.072218748333317 -6.843977922934042 1.2637331838045096 0.8906886826103865 1.6894540861798926 0.9310879214165276 0.0967655304069222 0.16420385725939576 0.5076609415478937 0.059997647358993426 0.1384112952523189 1.432260705426282e-07 6.843977922934042 0.7987654035695061 DLNPFTPLVGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLNPFTPLVGIR 12 0 Q86U90 Q86U90 YRDC YrdC domain-containing protein, mitochondrial 0 2135050.0 420440.0 646810.0 1067800.0 False True 575888.0299637808 618231.7954853597 815607.6320313088 1.0 1.0735277750507197 1.4162607826431202 19.135428809856208 -6.941381809640497 0.646584096227488 0.9962259274910492 1.512566151166033 0.99833930694439 0.007392234083257563 0.08714191906680897 0.05178179960308976 0.0072734711529976745 0.029323426337444457 1.144506307230521e-07 6.941381809640497 0.5163402236749839 DLNYCFSGMSDHR ddPTM_RPMI8226_Bortezomib_1h_R1 2 DLNYCFSGMSDHR 13 0 P55795;P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 301574000.0 75539000.0 76618000.0 149417000.0 False True 99032360.52071652 65186893.05462491 133956762.14907005 1.0 0.6582383042458985 1.35265645941104 26.561396691768863 -6.7729138635987045 1.563620228458135 0.8047025430400742 1.356969509218364 0.7414650371268906 0.1441527390053468 0.26174587680972033 1.2633879769152807 0.07265525618672637 0.17246886709445344 1.6868875634078258e-07 6.7729138635987045 0.5522669661782899 DLNYCFSGMSDHR ddPTM_RPMI8226_Bortezomib_2h_R1 2 DLNYCFSGMSDHR 13 0 P55795;P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 63694440.0 30163100.0 9230240.0 24301100.0 False True 29205588.90094621 12915922.96706573 17935912.892626837 1.0 0.44224148367188976 0.6141260480471169 24.79974113975991 -10.371835769248644 5.08399294250204 1.0003021275744155 0.5281837658594564 0.9094728210032509 0.07017157956348076 0.00024045333524979517 2.970974017173584e-05 0.06798598576996139 0.022647779918844983 4.247801664407875e-11 10.371835769248644 -0.47211836171495913 DLNYCFSGMSDHR ddPTM_RPMI8226_Bortezomib_8h_R1 2 DLNYCFSGMSDHR 13 0 P55795;P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 224322000.0 35055800.0 161999000.0 27267200.0 False True 53182211.52226982 133089012.74603577 21877825.96836166 1.0 2.5025099358702922 0.41137488160304153 25.66444043550025 -6.7138638204958285 1.780964358060245 1.9200702369298688 0.4156251547982079 0.4834640713473074 0.6327892056729318 0.36745532508835355 2.2741531870963225 0.2824692309104619 0.7143879488412291 1.9325742094501937e-07 6.7138638204958285 -1.5044450821316608 DLNYCFSGMSDHR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DLNYCFSGMSDHR 13 0 P55795;P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 205916000.0 75539000.0 52913000.0 77464000.0 False True 103467809.66471799 50575128.700107954 59168598.621158645 1.0 0.4888006121323531 0.5718551384521562 26.624606753291754 -10.761007301236656 7.0318095198733035 1.009800396600563 0.5303278752922547 0.9770844431391021 0.033906868385345526 0.005187605062001625 0.00017631278740827799 0.03269188261047794 0.01094339471487417 1.733774849774087e-11 10.761007301236656 -0.4794725213083084 DLNYCFSGMSDHR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DLNYCFSGMSDHR 13 0 P55795;P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 62803900.0 30163100.0 9959700.0 22681100.0 False True 25081954.10189737 9906045.119254332 27423613.144442387 1.0 0.39494710336404654 1.0933603112832375 24.580146415194186 -6.677550941628745 1.9106071873509587 0.6163624895720097 1.0906624272237497 0.3131712437678853 0.2565690252318564 0.4438491270966658 3.130407044175258 0.10783924192480158 0.28531234132522015 2.1011112996259017e-07 6.677550941628745 0.47429993765174006 DLNYCFSGMSDHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLNYCFSGMSDHR 13 0 P55795;P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 91487000.0 26495800.0 41693000.0 23298200.0 False True 34299335.41030017 39372747.89890748 19058166.65971943 1.0 1.1479157665277606 0.5556424470544178 25.03167728697834 -6.840590082185605 1.2798002970502609 1.0786792447056663 0.5359517479795892 0.9254390483609986 0.06872547549121256 0.16811285974596996 0.5346387648645381 0.042105541921104064 0.09701075259067979 1.443477164463856e-07 6.840590082185605 -0.5427274967260771 DLPEHAVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLPEHAVLK 9 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 30742830.0 568830.0 16325000.0 13849000.0 False True 745741.6385575562 13889373.634351593 12416038.328988481 1.0 18.624913664760605 16.649249132721202 19.508316371229046 -10.045558245769481 12.096314065616822 0.999992848078971 17.637081394712347 0.9895343963792069 0.8065616677457436 0.0 0.0 0.7809499767123608 0.2603166589041202 9.004129950067398e-11 10.045558245769481 16.637088546633375 DLPEHAVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLPEHAVLK 9 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 27727500.0 8406900.0 2826600.0 16494000.0 False True 8140027.561204398 3955276.120524271 12173726.590606455 1.0 0.485904512089766 1.4955387434591476 22.956602248624737 -6.768311653055854 1.5811090067893299 0.7044836660314556 1.5008302839900027 0.7239567026011873 0.2165715950017154 0.269186927274277 1.3278475602433482 0.10798703829892688 0.2574340503047753 1.704858530354751e-07 6.768311653055854 0.7963466179585471 DLPEHAVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLPEHAVLK 9 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 27853830.0 568830.0 14444000.0 12841000.0 False True 779141.8230527489 13805816.32007936 9808220.26869642 1.0 17.719259718323052 12.588491566614811 19.571526432751938 -9.736436219495323 10.26500767828543 1.0000000010631886 15.15387564630941 0.910287328373197 2.0946273267013233 0.0 0.0 2.028114188206297 0.6760380627354322 1.8346945906531443e-10 9.736436219495323 14.153875645246222 DLPEHAVLK(ub)MK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLPEHAVLKMK 11 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 16587700.0 7202700.0 3595300.0 5789700.0 True False 6974054.231058654 5030922.039241819 4273203.882723062 1.0 0.721376959880355 0.6127288003716017 22.73356615204722 -13.999999999997138 0.13023952432643898 2.3241253640321546 0.4610363640788016 0.9996445325408971 0.003075054806375732 11.936375573318044 0.1122510946236053 4.045104695817233 0.1349169329165032 1.0000000000065894e-14 13.999999999997138 -1.863088999953353 DLPEHAVLK(ub)MK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLPEHAVLKMK 11 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 37387100.0 6417000.0 7439100.0 23531000.0 True False 9735058.145539535 6111534.483046416 18880087.535996318 1.0 0.6277861304656546 1.9393913476158233 23.214758165222083 -6.8308797389749945 1.3239148356366521 0.8012299609702295 1.975339293969324 0.9076343192129384 0.16773084740246974 0.17972743600773816 0.6157718932423744 0.09946374568621606 0.22889683281640366 1.476115229590676e-07 6.8308797389749945 1.1741093329990946 DLPEHAVLK(ub)MK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLPEHAVLKMK 11 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 16825500.0 7202700.0 6122700.0 3500100.0 True False 5989364.183712424 6089715.799839203 4231954.727366084 1.0 1.0167549698179446 0.7065782940490631 22.513971427481497 -6.894134764362674 0.9975798956612282 1.015052010383053 0.6776323867002595 0.9834162291715921 0.018342343184397043 0.11585324529624495 0.20275369792515613 0.013927876515236852 0.03528200649930213 1.2760427831115648e-07 6.894134764362674 -0.33741962368279343 DLPEHAVLK(ub)MK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLPEHAVLKMK 11 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 29757600.0 6417000.0 7029600.0 16311000.0 True False 8306932.997980654 6638396.580484966 13342565.364993189 1.0 0.7991392951043068 1.6061963384364186 22.985884487314532 -6.840826264161942 1.2786218397962035 0.8931586724084803 1.6331666308938744 0.9258552086545572 0.09341139827247086 0.16783574684396152 0.5326593420384493 0.05727892871800576 0.13198497997864364 1.442692372995157e-07 6.840826264161942 0.740007958485394 DLPIK(ub)LNQWCNVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLPIKLNQWCNVVR 14 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 4828680.0 920680.0 2259000.0 1649000.0 True False 1207020.395877803 1921966.0055130322 1478377.2983249351 1.0 1.5923227246837752 1.2248155071561888 20.20301862386214 -10.165242913281736 4.548699116915193 0.9999411504872107 1.4085691158466669 0.6223461331890379 0.15003419335708323 9.920830661963841e-05 1.8206305838644454e-05 0.1452930942610338 0.04842332767608139 6.835292229650352e-11 10.165242913281736 0.4086279653594562 DLPIK(ub)LNQWCNVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLPIKLNQWCNVVR 14 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 6061080.0 920680.0 1924400.0 3216000.0 True False 1261080.2764414758 1839373.644860202 2456447.035599073 1.0 1.4585698303446295 1.9478910910657412 20.26622868538503 -6.970300676077181 0.250901243092113 0.846423885038651 2.574385044717631 0.9999846334535764 0.0015172039885744159 0.07620526027481991 0.008680387225159422 0.010847369443043998 0.046828043120506854 1.0707777146059103e-07 6.970300676077181 1.72796115967898 DLPIK(ub)LNQWCNVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLPIKLNQWCNVVR 14 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 8124900.0 2680500.0 5444400.0 0.0 True False 3469960.0905543384 5141414.353987764 0.0 1.0 1.4816926477002808 0.0 21.72648763919098 -6.841048876470107 1.4268112165918876 1.2582881475590124 9.7500395303256e-21 0.8816990270668834 0.2122549813451576 0.18333441427515218 0.7494350693602153 0.1193344967467539 0.2549618097578368 1.4419530617775725e-07 6.841048876470107 -1.2582881475590124 down DLPNALDEK(ub)QLIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLPNALDEKQLIEK 14 1 Q9NVJ2 Q9NVJ2 ARL8B ADP-ribosylation factor-like protein 8B 1 13529800.0 4814700.0 6358300.0 2356800.0 True False 4003636.3773751757 6324046.5758762695 2849595.9833880165 1.0 1.5795756606703575 0.7117519461785489 21.93287951942725 -6.726691602810614 1.735155682611795 1.3500586164905026 0.7125574521507657 0.5439450625567055 0.24370926871626672 0.3424642147589184 2.0183797675072963 0.11137215943425889 0.2774181278990819 1.8763264347149274e-07 6.726691602810614 -0.6375011643397369 DLQAEALCK(ub)LDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLQAEALCKLDR 12 1 J3QTA2;Q99933-4;Q99933-3;Q99933-2;Q99933 J3QTA2 BAG1 BAG family molecular chaperone regulator 1 1 76803000.0 29456000.0 30066000.0 17281000.0 True False 38617101.25230975 25580269.996350065 15492927.891057104 1.0 0.6624078236535186 0.4011934450965671 25.202736538342865 -7.620784308577505 0.19064585088523425 1.2265771688292466 1.194927235409837e-10 0.999941641394665 0.00187255989375532 0.13325179091645462 0.021272839776543852 0.042976122344301974 0.07676669855269379 2.39450468675546e-08 7.620784308577505 -1.226577168709754 down DLQAEALCK(ub)LDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLQAEALCKLDR 12 1 J3QTA2;Q99933-4;Q99933-3;Q99933-2;Q99933 J3QTA2 BAG1 BAG family molecular chaperone regulator 1 1 47391000.0 21233000.0 19546000.0 6612000.0 True False 20558970.037356578 27350819.731043465 4880118.844251846 1.0 1.330359433441743 0.2373717572127616 24.293264654462288 -6.8256355961891 1.3472703888419508 1.177121778939249 0.21049132283525526 0.8968678149009651 0.1469850428470561 0.18625745830418838 0.6627110771037014 0.08569531619276059 0.19728555841164627 1.494047495393143e-07 6.8256355961891 -0.9666304561039937 down DLQAEALCK(ub)LDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLQAEALCKLDR 12 1 J3QTA2;Q99933-4;Q99933-3;Q99933-2;Q99933 J3QTA2 BAG1 BAG family molecular chaperone regulator 1 1 113042000.0 52650000.0 47243000.0 13149000.0 True False 79873899.23058385 38812117.53875621 10550094.38658856 1.0 0.48591740121152094 0.13208437910526988 26.251220808136324 -8.228540811719471 0.3536145109953067 1.1032646282912852 2.1440364563326187e-22 0.998114951239184 0.015470943931716915 0.10047163488095137 0.08692070917212719 0.07284026788792491 0.08755643754870987 5.908254416476276e-09 8.228540811719471 -1.1032646282912852 DLQAEALCK(ub)LDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLQAEALCKLDR 12 1 J3QTA2;Q99933-4;Q99933-3;Q99933-2;Q99933 J3QTA2 BAG1 BAG family molecular chaperone regulator 1 1 64264000.0 29456000.0 24405000.0 10403000.0 True False 40346679.21846905 23326706.40345728 7946025.656510307 1.0 0.5781567865139016 0.1969437339188238 25.265946599865757 -7.765517528533208 0.3448019301847046 1.0752707881680714 5.76338091796322e-22 0.9989803969990385 0.01047299850832365 0.11831105322627324 0.05530779720517339 0.03515212751441229 0.07938219769244072 1.7158624549030674e-08 7.765517528533208 -1.0752707881680714 down DLQAEALCK(ub)LDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLQAEALCKLDR 12 1 J3QTA2;Q99933-4;Q99933-3;Q99933-2;Q99933 J3QTA2 BAG1 BAG family molecular chaperone regulator 1 1 42651100.0 21233000.0 15166000.0 6252100.0 True False 17656180.28138972 15084297.747784695 7559385.203555744 1.0 0.8543352813226603 0.42814386141738825 24.073669929896564 -6.952011935289373 0.5363002108969378 1.0064319328767697 0.2564899745491782 0.9993498671527475 0.0061868139332887226 0.08268774995688405 0.03269549195566025 0.006839906063891372 0.03527460322200347 1.1168325545448872e-07 6.952011935289373 -0.7499419583275915 down DLQAEALCK(ub)LDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLQAEALCKLDR 12 1 J3QTA2;Q99933-4;Q99933-3;Q99933-2;Q99933 J3QTA2 BAG1 BAG family molecular chaperone regulator 1 1 110718300.0 52650000.0 50486000.0 7582300.0 True False 68156462.88665754 47676409.719239295 6202399.200967921 1.0 0.6995141428997562 0.0910023633603515 26.022347130228773 -7.356337035763802 0.6043210767000229 1.0007240584256465 4.4887356737297127e-26 0.9957934869069854 0.02452475455542192 0.10534821781679587 0.07800587959904064 0.023247215853586696 0.06415768585418082 4.4021310198130794e-08 7.356337035763802 -1.0007240584256465 down DLQAEALCK(ub)LDRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLQAEALCKLDRR 13 2 J3QTA2;Q99933-4;Q99933-3;Q99933-2;Q99933 J3QTA2 BAG1 BAG family molecular chaperone regulator 1 1 90968000.0 45403000.0 31002000.0 14563000.0 True False 68879670.4039165 25469450.880268402 11684616.666810345 1.0 0.36976731640719657 0.16963810364205748 26.037574903523343 -12.965730974225513 0.17615478104603371 3.218773099318515 1.6723553194455312e-19 0.9994822497804053 0.008051035778202001 8.15978556768943 0.12563357206389095 6.4200603593532 0.15251118575243994 1.0821040582118881e-13 12.965730974225513 -3.218773099318515 DLQELQK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLQELQKK 8 1 I3L288;I3NI21;I3NI23;Q96B96;Q96B96-2 I3L288 TMEM159 Promethin 1 3118950.0 796950.0 1194100.0 1127900.0 True False 1044809.1676747772 1015944.9345653435 1011195.7275807734 1.0 0.9723736793258897 0.9678281535672103 19.994808030299822 -13.999983002267147 0.2539460804673081 1.1960129833787565 0.9660678714765737 0.9995500800629286 0.00030148906445154604 14.158194204753526 0.1594624415260724 1.4189960744868757 0.002052744564709757 1.0000391394922125e-14 13.999983002267147 -0.2299451119021828 DLQLLQGSK(ub)FLQNLVPHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLQLLQGSKFLQNLVPHR 18 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 18424500.0 6169800.0 4930900.0 7323800.0 True False 5973943.076177776 6899834.084303812 5405477.070709567 1.0 1.154988254209887 0.904842413424548 22.51025206005167 -6.739148943038734 1.6901591466482864 1.0923097738445235 0.9047327161627502 0.6009776826616835 0.06512056506128241 0.3193528237399763 1.7909937813609422 0.03048682584241935 0.07487190786499087 1.8232702972039285e-07 6.739148943038734 -0.18757705768177335 DLQLLQGSK(ub)FLQNLVPHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLQLLQGSKFLQNLVPHR 18 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 43149600.0 6272500.0 10373000.0 26504100.0 True False 9515841.081174497 8521857.105381075 21265553.0178403 1.0 0.8955442858582566 2.234752854365196 23.181899747632418 -6.888056093466635 1.0338454637215135 0.9246533724932511 2.34563077174012 0.9796234450135659 0.08681631769556658 0.1207332057675894 0.23119023656660806 0.06414299182708756 0.15882568970963065 1.2940286939354912e-07 6.888056093466635 1.420977399246869 up DLQLLQGSK(ub)FLQNLVPHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLQLLQGSKFLQNLVPHR 18 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 14061100.0 6169800.0 2674700.0 5216600.0 True False 5130462.068483887 2660290.860213617 6307366.941166805 1.0 0.518528511604368 1.2293954924474682 22.290657335485946 -6.724329257997288 1.7441895097392195 0.7084343861652288 1.228532465465362 0.5326822278737993 0.20250461347387985 0.3469626772260117 2.0651563595279767 0.09211516046497108 0.23003494531251817 1.8865605211883538e-07 6.724329257997288 0.5200980793001332 DLQLLQGSK(ub)FLQNLVPHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLQLLQGSKFLQNLVPHR 18 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 61962600.0 6272500.0 10572000.0 45118100.0 True False 8119874.89945982 9983658.906465113 36907068.75079996 1.0 1.2295335864262247 4.545275537835592 22.953026069724867 -6.92089209379895 0.8180881063195167 0.9291663159502224 5.091087695282352 0.9944250570847615 0.12094846778916077 0.09764969880592136 0.10291676152399117 0.10470469483577874 0.3163632842604687 1.1997973716245985e-07 6.92089209379895 4.16192137933213 up DLQMVNISLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLQMVNISLR 10 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7 Q99623 PHB2 Prohibitin-2 0 14268700.0 6221000.0 4123900.0 3923800.0 False True 8155791.244249699 3508630.194836294 3517802.8157473453 1.0 0.4302010791791759 0.43132575496308817 22.9593934179082 -10.004854467120825 5.270312466610764 1.0000032401483288 0.4307634170693279 0.9999970718201384 0.00045914697241801114 1.748056916480825e-08 3.3008118692177516e-09 0.0004445696715592141 0.00014818904722652763 9.888844161261614e-11 10.004854467120825 -0.5692398230790008 DLQMVNISLR ddPTM_RPMI8226_Bortezomib_2h_R1 2 DLQMVNISLR 10 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7 Q99623 PHB2 Prohibitin-2 0 96607600.0 34797600.0 28307000.0 33503000.0 False True 33692969.235243276 39610132.719054855 24727559.231544122 1.0 1.1756201254480758 0.7339085807159667 25.005944237586668 -6.79882151335963 1.4606858989729703 1.0970441378002953 0.7279852375637186 0.8286929420424948 0.07515644761240459 0.22245148022879896 0.9371360526586289 0.040479677302761814 0.0942106085888334 1.5891997447918412e-07 6.79882151335963 -0.3690589002365767 DLQMVNISLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLQMVNISLR 10 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7 Q99623 PHB2 Prohibitin-2 0 25386300.0 6221000.0 4398300.0 14767000.0 False True 8521071.816203699 4203968.562766897 11279338.735911539 1.0 0.49336147534546254 1.323699527383716 23.02260347943109 -6.741588633412666 1.681021033938699 0.6991020775288277 1.3243419315628433 0.6119690300178282 0.21286186120027126 0.31496193391999744 1.7482008801119104 0.10015243297894168 0.24532440064321415 1.8130566186830548e-07 6.741588633412666 0.6252398540340156 DLQMVNISLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DLQMVNISLR 10 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7 Q99623 PHB2 Prohibitin-2 0 68557200.0 34797600.0 15648400.0 18111200.0 False True 28935746.19505901 15564098.963235777 21898168.183272667 1.0 0.5378848313887085 0.756786019467227 24.786349513020944 -10.048621088907572 4.995257112367262 1.000006237054288 0.6473354254255417 0.7758208266794231 0.08936603582197587 123780075.94465898 18.13480852106992 8879.776563408153 0.030592371057791664 8.940852105613238e-11 10.048621088907572 -0.35267081162874625 DLQNVNITLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLQNVNITLR 10 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2;D6RBK0 P35232 PHB Prohibitin 0 131167000.0 38888000.0 47404000.0 44875000.0 False True 50982544.591927685 40331507.97934479 40231765.47139565 1.0 0.7910846408739409 0.7891282358190834 25.60350004578154 DLQPFPTCQALVYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLQPFPTCQALVYR 14 0 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 10462700.0 2319400.0 3914100.0 4229200.0 False True 3040755.861101552 3330131.5370423007 3791602.9533510096 1.0 1.095165705225647 1.2469277793243994 21.535998557966053 -6.964219690181809 0.37120088201074736 0.9884871204751571 1.3588989551054134 0.9998961423753266 0.0010362782394561225 0.0782267608650754 0.015799727256863932 0.001996761366405128 0.012880800379466092 1.0858761883954182e-07 6.964219690181809 0.3704118346302563 DLQPFPTCQALVYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLQPFPTCQALVYR 14 0 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 42106100.0 7360100.0 21560000.0 13186000.0 False True 11165809.795385007 17712449.55095113 10579781.320370886 1.0 1.586311237208424 0.9475158106977306 23.41258454998189 -6.66533085396357 1.9538113683560485 1.3757285236498158 0.9501374964632744 0.258580927813156 0.24932271285445184 0.47192845941470596 3.468482634859464 0.10289550975087232 0.27660713843257356 2.1610715502170723e-07 6.66533085396357 -0.4255910271865414 DLQPFPTCQALVYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLQPFPTCQALVYR 14 0 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 8551700.0 2319400.0 2885400.0 3346900.0 False True 3176944.8594282046 2757913.4872581745 2556431.151569194 1.0 0.868102409481086 0.8046822543937094 21.599208619488945 -13.999999979787559 0.09679936302805218 1.6579679192350516 0.6626425636468352 0.9998096329196341 0.0011224728484929701 12.10556104695515 0.09199211742241432 1.60478418782633 0.1269344030665036 1.0000000465408676e-14 13.999999979787559 -0.9953253555882164 DLQQYQSQAK(ub)QLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLQQYQSQAKQLFR 14 1 O75396 O75396 SEC22B Vesicle-trafficking protein SEC22b 1 8997000.0 3395300.0 5601700.0 0.0 True False 4451271.180131973 4765948.195255579 0.0 1.0 1.070693741717681 0.0 22.085785964590674 -6.976380479587885 1.159122899844603 1.047042662518153 9.87331814322845e-22 0.9789803620116428 0.07088432290374104 0.09813832830817164 0.26006462205085534 0.051254796995224366 0.09545391987032517 1.0558920509763764e-07 6.976380479587885 -1.047042662518153 down DLQQYQSQAK(ub)QLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLQQYQSQAKQLFR 14 1 O75396 O75396 SEC22B Vesicle-trafficking protein SEC22b 1 15726200.0 4444000.0 5191300.0 6090900.0 True False 4302927.652522619 7264213.1622718675 4495510.566916748 1.0 1.6882024865124508 1.0447562520093094 22.036887152993085 -10.318221230917873 4.045744512788663 0.9993617197988913 1.366479369266251 0.30193290132931994 0.2626858253046896 186802747.55788678 1116.7658365317586 1112609.6762935135 0.08992434502542546 4.8059446981282244e-11 10.318221230917873 0.3671176494673596 DLQQYQSQAK(ub)QLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLQQYQSQAKQLFR 14 1 O75396 O75396 SEC22B Vesicle-trafficking protein SEC22b 1 14435000.0 3395300.0 3674800.0 7364900.0 True False 4650634.1645324575 3512435.185061456 5625462.304876735 1.0 0.755259403512891 1.209611873533011 22.148996026113565 -6.760409136677403 1.6110352168319533 0.8579128061163878 1.21129945320988 0.692599429848748 0.10294419377110847 0.28222878074481483 1.4438094972783608 0.050415985125845726 0.12110358520406116 1.7361644661287735e-07 6.760409136677403 0.3533866470934922 DLQQYQSQAK(ub)QLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLQQYQSQAKQLFR 14 1 O75396 O75396 SEC22B Vesicle-trafficking protein SEC22b 1 16891900.0 4444000.0 6202700.0 6245200.0 True False 3695382.9025807017 6169284.823960446 7551042.445457748 1.0 1.6694575329804318 2.0433721334220643 21.81729242842736 -9.509966777598352 0.1468279492312138 4.597559168025516e-12 2.6583355696377775 0.999796186399253 0.006161852263705193 0.9690832643344655 0.05882530627792763 0.7194440414303387 0.3187713801011044 3.090531841142593e-10 9.509966777598352 2.65833556963318 DLQQYQSQAK(ub)QLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLQQYQSQAKQLFR 14 1 O75396 O75396 SEC22B Vesicle-trafficking protein SEC22b 1 28172100.0 5650400.0 7133700.0 15388000.0 True False 7314554.186035514 6736703.323973724 12587541.894213414 1.0 0.9209998521625574 1.7208898278783356 22.80233850570493 -6.88262157773727 1.0651094217062134 0.9491158579620095 1.7804972037483104 0.9757376719511699 0.056059233804992135 0.12533146575077628 0.2584892546922434 0.040444673353946074 0.09848738541008879 1.3103231751048846e-07 6.88262157773727 0.831381345786301 DLRPAGSK(ub)TR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLRPAGSKTR 10 2 Q9NZ01;M0R2N5;Q9NZ01-2;M0R329 Q9NZ01 TECR Very-long-chain enoyl-CoA reductase 1 14934000.0 0.0 0.0 14934000.0 True False 0.0 0.0 13388772.937043399 0.0 DLRPAGSK(ub)TR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLRPAGSKTR 10 2 Q9NZ01;M0R2N5;Q9NZ01-2;M0R329 Q9NZ01 TECR Very-long-chain enoyl-CoA reductase 1 16530000.0 0.0 0.0 16530000.0 True False 0.0 0.0 12625954.446036264 0.0 DLSEVSETTESTDVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLSEVSETTESTDVK 15 0 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 0 9999700.0 0.0 5091300.0 4908400.0 False True 0.0 4331697.885731965 4400525.852697455 0.0 DLSEVSETTESTDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLSEVSETTESTDVK 15 0 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 0 5162900.0 1510300.0 0.0 3652600.0 False True 1462356.353196424 0.0 2695874.4843488066 1.0 0.0 1.843514050768921 20.479863485501028 -6.759386757670891 1.6148216178175616 0.4187085275471995 1.85004289734913 0.6884822703271681 0.42056500255407603 0.2839265303342023 1.4590878928142446 0.20550596265443413 0.49415422873184134 1.7402564109141415e-07 6.759386757670891 1.4313343698019305 DLSEVSETTESTDVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLSEVSETTESTDVK 15 0 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 0 7571300.0 0.0 3441700.0 4129600.0 False True 0.0 3289634.3138200794 3154273.531781689 0.0 DLSHIGDAVVISCAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLSHIGDAVVISCAK 15 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 89657300.0 19574100.0 37289400.0 32793800.0 False True 25661834.65585407 31725966.872942716 29400612.15634214 1.0 1.2363093792167847 1.1456940842550074 24.613120981727356 -10.110603396462997 4.272576103697228 0.9999710815478811 1.1910017317614254 0.8555734655003192 0.03699353934113109 25777734.58486999 0.46451168370769963 7676.624877030116 0.012663872474584576 7.751693697208687e-11 10.110603396462997 0.19103065021354437 DLSHIGDAVVISCAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLSHIGDAVVISCAK 15 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 32441100.0 14101200.0 4301300.0 14038600.0 False True 13653565.124606626 6018831.5209831735 10361469.511027519 1.0 0.44082490295050925 0.7588838092077467 23.702774371109687 -10.211278611425165 5.6783074694748095 1.0000132927715597 0.5998543560791274 0.678495442059488 0.1298470047463686 2.1851433288210708e-05 3.0352064542871997e-06 0.12572799383180502 0.041907940578126836 6.1478234699791e-11 10.211278611425165 -0.4001589366924323 DLSHIGDAVVISCAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLSHIGDAVVISCAK 15 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 168984900.0 4013200.0 161606000.0 3365700.0 False True 6088317.804219936 132766146.66655874 2700467.9197612875 1.0 21.806704402739268 0.44354910610769016 22.53761223739779 -6.437503077063156 2.953649965573434 9.999999999999998 0.34577551402291246 0.2562787234417796 8.574018301513263 0.6688689032749512 10.710892298697924 3.351536088650205 12.600832651130606 3.65171539932367e-07 6.437503077063156 -9.654224485977085 DLSHIGDAVVISCAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLSHIGDAVVISCAK 15 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 102624100.0 19574100.0 47905000.0 35145000.0 False True 26811173.740162827 45788398.699349396 26844474.833995428 1.0 1.7078103011491401 1.0012420602751426 24.676331043250247 -10.339752534377045 5.237943056418753 0.9998766015558654 1.3545261807121642 0.25131840383614223 0.2884552764329488 0.00041581550764232796 5.241415186498276e-05 0.2793922103290073 0.09309854014586072 4.573487175540874e-11 10.339752534377045 0.3546495791562988 DLSHIGDAVVISCAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLSHIGDAVVISCAK 15 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 23075000.0 14101200.0 1664100.0 7309700.0 False True 11725772.589079859 1655135.1630020104 8838124.47376585 1.0 0.14115361273025437 0.7537349378578894 23.483179646543963 -10.348425548510646 7.66575244870649 1.0000055920060766 0.44744427536401077 0.52034556671832 0.25008527875344483 2.390121682341821e-05 2.0313230588772957e-06 0.24214647936260975 0.08071467664531094 4.483058968881557e-11 10.348425548510646 -0.5525613166420659 DLSHIGDAVVISCAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLSHIGDAVVISCAK 15 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 20485000.0 4013200.0 8851700.0 7620100.0 False True 5195166.511998756 8359095.113730341 6233319.9888286805 1.0 1.6090138967488676 1.1998306453570267 22.30873855949024 -10.104546830684487 4.645816907572806 0.9999720280081109 1.4044222708198124 0.5656868845291697 0.167048362894735 4.840167265206127e-05 9.32901090705128e-06 0.1617550532660026 0.05391462728798128 7.86055424935517e-11 10.104546830684487 0.4044502428117015 DLSHIGDAVVISCAK(ub)DGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLSHIGDAVVISCAKDGVK 19 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 7421870600.0 2789146300.0 3109464700.0 1523259600.0 True False 3656597809.431191 2645544687.3584695 1365647308.7298474 1.0 0.7234989531894956 0.373474847358803 31.767854806821337 -6.967923303648848 0.3037215065056775 1.0580826501803102 0.0278650212784261 0.9999613517315342 0.0015937476774956674 0.07698246384108696 0.01142933377149929 0.005702498570516703 0.03127056328904088 1.0766553340389676e-07 6.967923303648848 -1.030217628901884 down DLSHIGDAVVISCAK(ub)DGVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLSHIGDAVVISCAKDGVK 19 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 8538520700.0 3900872200.0 2726491100.0 1911157400.0 True False 3777041147.2404904 3815193214.6932507 1410567943.446971 1.0 1.0101010462860947 0.3734584529155932 31.814609354628644 -6.903297831953453 0.9402033302497932 1.0241278431476875 0.3019748385690835 0.988136264782148 0.032432675693655155 0.10901776537361378 0.16405371724461934 0.025702854463667324 0.06805022739303639 1.2494019172393197e-07 6.903297831953453 -0.722153004578604 down DLSHIGDAVVISCAK(ub)DGVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLSHIGDAVVISCAKDGVK 19 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 40666924700.0 11374400000.0 13735659700.0 15556865000.0 True False 17255796380.02574 11284423909.335897 12482043813.933828 1.0 0.6539497604641452 0.7233536800644148 34.00636200665174 -10.813308391153463 7.195069744195985 1.0141249631730322 0.68865172026428 0.9640709819901601 0.028334031528301457 0.00636322484232736 0.000165107392095041 0.027191848003074778 0.009144769353335616 1.537062789209015e-11 10.813308391153463 -0.32547324290875224 DLSHIGDAVVISCAK(ub)DGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLSHIGDAVVISCAKDGVK 19 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 8659346800.0 2789146300.0 3908305300.0 1961895200.0 True False 3820369060.9546404 3735623448.8086886 1498535960.2599635 1.0 0.977817427899289 0.3922490043109884 31.831064868344228 -6.914904455064249 0.861666342750207 1.0154411431920578 0.30806382043316893 0.9926444639504709 0.024135294151023827 0.10126366692392187 0.12183581276405737 0.02025214027858451 0.05800052527743006 1.2164535914197673e-07 6.914904455064249 -0.7073773227588889 down DLSHIGDAVVISCAK(ub)DGVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLSHIGDAVVISCAKDGVK 19 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 9205315900.0 3900872200.0 2808103600.0 2496340100.0 True False 3243748072.2395053 2792975788.5418754 3018313273.1374907 1.0 0.8610335101065929 0.9305017547351102 31.59501463006292 -10.28405035050739 4.8656160028398165 1.0000342346357298 0.895767632420759 0.750107926437278 0.02836029211144555 1.0535600171209366e-05 1.5502458419928579e-06 0.027468749977554083 0.009153244920053816 5.199357136017954e-11 10.28405035050739 -0.10426660221497086 DLSHIGDAVVISCAK(ub)DGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLSHIGDAVVISCAKDGVK 19 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 38624473700.0 11374400000.0 16623057500.0 10627016200.0 True False 14724385022.94389 15697969737.283041 8693008293.99434 1.0 1.0661205688945303 0.590381756552052 33.777488328744184 -6.871750429969301 1.1248646958201856 1.0378178628334547 0.5615859356471458 0.9663956738893951 0.03857297328548611 0.1351839688573567 0.31863629205561866 0.026584542051183886 0.06313510985705797 1.3435368111443258e-07 6.871750429969301 -0.4762319271863089 DLSKPIGALNPK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLSKPIGALNPKR 13 2 A0A3B3IU76;A0A3B3IS13;H0YAC6;A0A494BZW2;E9PEM5;A0A494C1L5;Q5T321;A0A0D9SF28;F5GXV7;Q8NFP9-3;P50851-2;P50851;Q8NFP9 A0A3B3IU76 LRBA;NBEA Neurobeachin;Lipopolysaccharide-responsive and beige-like anchor protein 1 11381300.0 4531000.0 4926800.0 1923500.0 True False 5940184.87826641 4191740.644515988 1724474.6715148645 1.0 0.7056582800734832 0.2903065656801808 22.502076402506347 -7.104801939108121 0.3623344456468432 1.0384748106072084 1.1634057009993737e-17 0.9998870103527489 0.003094624991788091 0.0767802864223388 0.016926697350459815 0.006623341685951487 0.03574311331658849 7.855938246070138e-08 7.104801939108121 -1.0384748106072084 down DLSKPIGALNPK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLSKPIGALNPKR 13 2 A0A3B3IU76;A0A3B3IS13;H0YAC6;A0A494BZW2;E9PEM5;A0A494C1L5;Q5T321;A0A0D9SF28;F5GXV7;Q8NFP9-3;P50851-2;P50851;Q8NFP9 A0A3B3IU76 LRBA;NBEA Neurobeachin;Lipopolysaccharide-responsive and beige-like anchor protein 1 10644200.0 3831800.0 3553600.0 3258800.0 True False 3710161.606421278 4972571.011779191 2405222.5180955725 1.0 1.3402572554179384 0.6482797175014663 21.82305059813919 -6.77300874097992 1.5630383414004354 1.1944111782173255 0.6439462604928774 0.7419068975480949 0.14352396808082757 0.2615882217483094 1.2616639714884057 0.07236160265600168 0.1717724967075867 1.6865190807304783e-07 6.77300874097992 -0.550464917724448 DLSKPIGALNPK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLSKPIGALNPKR 13 2 A0A3B3IU76;A0A3B3IS13;H0YAC6;A0A494BZW2;E9PEM5;A0A494C1L5;Q5T321;A0A0D9SF28;F5GXV7;Q8NFP9-3;P50851-2;P50851;Q8NFP9 A0A3B3IU76 LRBA;NBEA Neurobeachin;Lipopolysaccharide-responsive and beige-like anchor protein 1 31972100.0 13161000.0 7716100.0 11095000.0 True False 19966199.197981305 6339101.668835533 8902068.386888744 1.0 0.31749165707394383 0.44585693544461846 24.251056389076272 -10.103528162513157 6.0759357272852395 1.0000022095917165 0.3816742962654617 0.9686883552712523 0.052404905449787625 1.5685523165899724e-06 2.3146245712938503e-07 0.05074101217462577 0.016913610505544012 7.879013370852674e-11 10.103528162513157 -0.6183279133262548 DLSKPIGALNPK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLSKPIGALNPKR 13 2 A0A3B3IU76;A0A3B3IS13;H0YAC6;A0A494BZW2;E9PEM5;A0A494C1L5;Q5T321;A0A0D9SF28;F5GXV7;Q8NFP9-3;P50851-2;P50851;Q8NFP9 A0A3B3IU76 LRBA;NBEA Neurobeachin;Lipopolysaccharide-responsive and beige-like anchor protein 1 11615500.0 4531000.0 4848700.0 2235800.0 True False 6206233.145670938 4634468.401493272 1707750.087746392 1.0 0.7467441671484697 0.275166924551909 22.56528646402924 -6.996779305383888 0.42361698973167844 1.0204354174459755 1.170641382141322e-13 0.9998171372998126 0.0040615696638312835 0.07497654584348507 0.01954138836285609 0.006031809892371538 0.03711507791708199 1.0074434894726384e-07 6.996779305383888 -1.0204354174458585 down DLSKPIGALNPK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLSKPIGALNPKR 13 2 A0A3B3IU76;A0A3B3IS13;H0YAC6;A0A494BZW2;E9PEM5;A0A494C1L5;Q5T321;A0A0D9SF28;F5GXV7;Q8NFP9-3;P50851-2;P50851;Q8NFP9 A0A3B3IU76 LRBA;NBEA Neurobeachin;Lipopolysaccharide-responsive and beige-like anchor protein 1 12494700.0 3831800.0 6773400.0 1889500.0 True False 3186311.4775222144 6736910.349785362 2284585.713939093 1.0 2.1143288712703683 0.7170001206899163 21.603455873573466 -6.694314266709823 1.851393895587508 1.6957845433248877 0.7216047821942153 0.3905492607638861 0.47088005382230735 0.4074616526196205 2.711141072782942 0.2032321125458572 0.5263107018833058 2.0215557992566467e-07 6.694314266709823 -0.9741797611306724 DLSKPIGALNPK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLSKPIGALNPKR 13 2 A0A3B3IU76;A0A3B3IS13;H0YAC6;A0A494BZW2;E9PEM5;A0A494C1L5;Q5T321;A0A0D9SF28;F5GXV7;Q8NFP9-3;P50851-2;P50851;Q8NFP9 A0A3B3IU76 LRBA;NBEA Neurobeachin;Lipopolysaccharide-responsive and beige-like anchor protein 1 19490300.0 13161000.0 0.0 6329300.0 True False 17037173.942094993 0.0 5177432.3441022225 1.0 0.0 0.3038903260422764 24.02218271116872 -10.362016546546675 5.763515817953613 1.0001784005586352 0.15194516302118066 0.9121552325958537 0.12406270609527373 0.0002844563841476961 3.1487316000771094e-05 0.12014778621715447 0.04004106621603385 4.344936697205152e-11 10.362016546546675 -0.8482332375374545 DLSLEEIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLSLEEIQK 9 0 P16949;P16949-2;A2A2D0;E5RGX5;Q93045;Q93045-2 P16949;E5RGX5 STMN1;STMN2 Stathmin;Stathmin-2 0 42303600.0 1984600.0 19818000.0 20501000.0 False True 2601829.8188937358 16861231.649958957 18379753.179478146 1.0 6.480528252661864 7.06416424548973 21.31109517032401 -9.703690889624392 0.5969133873858039 2.3417340850590434e-20 7.00426229204094 0.9991563864855187 0.07933712452786187 0.9888952642489319 0.2758735404677674 2.2163033246817934 0.10128882345321318 1.9783772549489405e-10 9.703690889624392 7.00426229204094 DLSLEEIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLSLEEIQK 9 0 P16949;P16949-2;A2A2D0;E5RGX5;Q93045;Q93045-2 P16949;E5RGX5 STMN1;STMN2 Stathmin;Stathmin-2 0 45348400.0 16080000.0 5000400.0 24268000.0 False True 15569549.201747 6997085.796741514 17911482.775605526 1.0 0.44940837438995324 1.1504175582421967 23.892223837670283 -6.697229296448808 1.8406016449787277 0.6571834382782547 1.1482372966961845 0.40450024473194046 0.232531172666147 0.40131786225452787 2.6412231342172965 0.10085855871564213 0.26028675514745764 2.0080323426401927e-07 6.697229296448808 0.4910538584179298 DLSLEEIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLSLEEIQK 9 0 P16949;P16949-2;A2A2D0;E5RGX5;Q93045;Q93045-2 P16949;E5RGX5 STMN1;STMN2 Stathmin;Stathmin-2 0 40834600.0 1984600.0 19961000.0 18889000.0 False True 2718360.2517983983 19079057.017800067 14427807.231166314 1.0 7.018590345108911 5.307540537212183 21.3743052318469 -9.841171714958309 8.012549338416417 0.9999999973486753 6.163065441160548 0.9238981191120795 0.6985331589723641 3.277147169401878e-08 5.031321344254701e-09 0.6763518228684029 0.22545060762280145 1.4415452686924135e-10 9.841171714958309 5.163065443811872 DLSLEEIQK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLSLEEIQKK 10 1 P16949;P16949-2;A2A2D0;E5RGX5;Q93045;Q93045-2 P16949;E5RGX5 STMN1;STMN2 Stathmin;Stathmin-2 1 82762000.0 13476000.0 25676000.0 43610000.0 True False 20444077.227565955 21093917.192496367 34990464.38505796 1.0 1.0317862213929712 1.711520847606575 24.28517961045764 -6.9166600461976655 0.849120359716161 0.9831222849082298 1.8131373281894414 0.9932019916105718 0.027058346463972476 0.10017694390527787 0.11608865560815282 0.022910284051563957 0.06658196860605504 1.2115461275310925e-07 6.9166600461976655 0.8300150432812116 DLSLEEIQK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLSLEEIQKK 10 1 P16949;P16949-2;A2A2D0;E5RGX5;Q93045;Q93045-2 P16949;E5RGX5 STMN1;STMN2 Stathmin;Stathmin-2 1 19577400.0 8633900.0 7394000.0 3549500.0 True False 7179470.396622753 7354167.054405915 4291684.038966294 1.0 1.0243328056433438 0.5977716742150113 22.775445994939894 -6.893379619180151 1.002153700260799 1.0210973732910575 0.5585558153007232 0.9829754862642632 0.02552149528941377 0.11644470889991367 0.20616246614940267 0.019312653396994096 0.04877214348770814 1.2782634785873408e-07 6.893379619180151 -0.46254155799033436 DLSLEEIQK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLSLEEIQKK 10 1 P16949;P16949-2;A2A2D0;E5RGX5;Q93045;Q93045-2 P16949;E5RGX5 STMN1;STMN2 Stathmin;Stathmin-2 1 67465000.0 13476000.0 25719000.0 28270000.0 True False 17444947.651673254 24287715.041182 23125150.07469544 1.0 1.3922492360619043 1.3256073068512395 24.05630593255009 -10.076457893772327 4.3882172343273655 0.9999699721602737 1.3589282714249336 0.9747968292305611 0.02720645380575386 4072844.7421037727 4685111.383277357 991.5498898512529 0.009313493322199738 8.385753772235841e-11 10.076457893772327 0.35895829926465983 DLSLLQIQMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLSLLQIQMR 10 0 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4;Q6N069-3;Q6N069-2;Q6N069-5;Q6N069-4;Q6N069 Q9BXJ9;Q6N069 NAA15;NAA16 N-alpha-acetyltransferase 15, NatA auxiliary subunit;N-alpha-acetyltransferase 16, NatA auxiliary subunit 0 23344600.0 8029100.0 7577400.0 7738100.0 False True 10526227.853914998 6446881.456473861 6937435.641096521 1.0 0.6124588547716155 0.6590618916268561 23.3274851935065 -10.795854385846667 10.78147568243625 1.0022929586212042 0.6357603733253178 0.9878712594647397 0.019025610126576373 0.0010518070578381647 1.991575365385008e-05 0.018477580864021365 0.006140489264305458 1.6000944327127704e-11 10.795854385846667 -0.3665325852958864 DLSLLQIQMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 DLSLLQIQMR 10 0 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4;Q6N069-3;Q6N069-2;Q6N069-5;Q6N069-4;Q6N069 Q9BXJ9;Q6N069 NAA15;NAA16 N-alpha-acetyltransferase 15, NatA auxiliary subunit;N-alpha-acetyltransferase 16, NatA auxiliary subunit 0 46041300.0 17499000.0 14146300.0 14396000.0 False True 16943503.82346831 19794991.36197992 10625255.729257356 1.0 1.16829385280759 0.6270990841068187 24.01422891113891 -6.823184499639143 1.3581801588348046 1.0904288396101254 0.6144720195292401 0.8915135491452589 0.07448566231469456 0.18938306043691447 0.6855812426048649 0.04308781158023697 0.09922928534936425 1.5025035277448774e-07 6.823184499639143 -0.47595682008088525 DLSLLQIQMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 DLSLLQIQMR 10 0 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4;Q6N069-3;Q6N069-2;Q6N069-5;Q6N069-4;Q6N069 Q9BXJ9;Q6N069 NAA15;NAA16 N-alpha-acetyltransferase 15, NatA auxiliary subunit;N-alpha-acetyltransferase 16, NatA auxiliary subunit 0 62618200.0 18011800.0 24567000.0 20039400.0 False True 27325217.438963555 20182826.90715291 16078603.80641895 1.0 0.7386154182390449 0.5884163169912111 24.703729640323402 -13.135036788049389 0.06817545703270796 2.397836738093707 2.2911375755156446e-11 0.9999440042499719 0.001272549081977387 9.157142447240858 0.06198671914754265 2.2781372223095904 0.4976809974404104 7.32762459950204e-14 13.135036788049389 -2.3978367380707954 DLSLLQIQMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DLSLLQIQMR 10 0 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4;Q6N069-3;Q6N069-2;Q6N069-5;Q6N069-4;Q6N069 Q9BXJ9;Q6N069 NAA15;NAA16 N-alpha-acetyltransferase 15, NatA auxiliary subunit;N-alpha-acetyltransferase 16, NatA auxiliary subunit 0 78001900.0 9684400.0 31988000.0 36329500.0 False True 13264984.391069442 30574664.389829602 27749220.32953869 1.0 2.3049152180242127 2.091915038228063 23.66111964215734 -10.184006684659824 4.672858965210784 0.9998165081843468 2.1984151281329836 0.9768560641327163 0.08695695930208742 0.00016700871440261222 2.9163596433947476e-05 0.0842083221821817 0.028065237929973057 6.546260979860977e-11 10.184006684659824 1.198598619948637 DLSLLQIQMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLSLLQIQMR 10 0 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4;Q6N069-3;Q6N069-2;Q6N069-5;Q6N069-4;Q6N069 Q9BXJ9;Q6N069 NAA15;NAA16 N-alpha-acetyltransferase 15, NatA auxiliary subunit;N-alpha-acetyltransferase 16, NatA auxiliary subunit 0 28720600.0 15922000.0 4444600.0 8354000.0 False True 13239848.464196637 4420656.057615979 10100782.775468195 1.0 0.3338902306601448 0.762907732877975 23.658383274181205 -10.563553018161443 6.7027792615394 1.0005362250937688 0.5483989817694044 0.5963512605247574 0.17514566185950572 0.0014050404193994535 9.148793941797394e-05 0.16977375477486178 0.056528019295195076 2.7317879300520312e-11 10.563553018161443 -0.45213724332436445 DLSLLQIQMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLSLLQIQMR 10 0 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4;Q6N069-3;Q6N069-2;Q6N069-5;Q6N069-4;Q6N069 Q9BXJ9;Q6N069 NAA15;NAA16 N-alpha-acetyltransferase 15, NatA auxiliary subunit;N-alpha-acetyltransferase 16, NatA auxiliary subunit 0 41233700.0 15092000.0 16709000.0 9432700.0 False True 19536891.507795587 15779129.46160856 7716045.387675251 1.0 0.8076581402580032 0.3949474451755236 24.219697604238444 -6.958646383615517 0.45410895553011243 1.0127641029180738 0.173367665874057 0.9997166526812108 0.004248856692101525 0.08018826240986893 0.02294507938113922 0.005551179027341422 0.03411830184989051 1.0999010493572038e-07 6.958646383615517 -0.8393964370440168 down DLSQAPFSWPAGALVAQACHAATAALHTHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLSQAPFSWPAGALVAQACHAATAALHTHR 30 0 Q6GMV3 Q6GMV3 PTRHD1 Putative peptidyl-tRNA hydrolase PTRHD1 0 25744000.0 10406000.0 7086600.0 8251400.0 False True 15786662.780502472 5821940.862141487 6620507.1732829055 1.0 0.3687885744498168 0.41937344613832195 23.912202889312574 -10.223300208353571 8.423076285291245 1.0000001738656603 0.3940810126768173 0.9947999296229804 0.020651187390166192 6.744088759055455e-08 6.190394870975272e-09 0.01999543216925349 0.0066651420701269 5.979980828235101e-11 10.223300208353571 -0.605919161188843 DLSTIEPLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLSTIEPLK 9 0 H0YN26;P39687;O95626;O43423 H0YN26 ANP32A;ANP32D;ANP32C Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member D;Acidic leucine-rich nuclear phosphoprotein 32 family member C 0 10704800.0 3813300.0 1418700.0 5472800.0 False True 3692248.8787948885 1985194.308422764 4039309.4995192853 1.0 0.5376653561529987 1.0939970820270581 21.81606837152283 -6.686076443188613 1.8800733373847176 0.7090925503196503 1.0920037875903383 0.35225650046791634 0.19569258101306441 0.42515588140987876 2.910393813738657 0.08336005353962724 0.21817788608988925 2.0602672394039842e-07 6.686076443188613 0.382911237270688 DLSTIEPLKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLSTIEPLKK 10 1 H0YN26;P39687;O95626 H0YN26 ANP32A;ANP32D Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member D 0 15444500.0 5004600.0 1131100.0 9308800.0 False True 4845731.71237954 1582754.1286085781 6870546.021986028 1.0 0.32662850990389486 1.417855223893975 22.20828310041673 -6.739802108563266 1.6876652562116 0.599241613802285 1.4184336406590448 0.603910466415404 0.2829233837967009 0.3181941124564512 1.779466711487879 0.13263186833400648 0.3255066703582731 1.8205302158490478e-07 6.739802108563266 0.8191920268567597 DLSTVEALQNLK(ub)NLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLSTVEALQNLKNLK 15 1 Q9BTT0;E9PPH5;Q9BTT0-3 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 52328000.0 12476000.0 24239000.0 15613000.0 True False 16356156.817755857 20622635.68288197 13997516.530471312 1.0 1.2608484934856166 0.855794957607397 23.96333046436711 -6.732817555465426 1.712881106833282 1.1564843561565743 0.8559068408231396 0.5722753068758908 0.10963266112235973 0.33099996190123615 1.9037842587932186 0.050694267102293106 0.12539874840876325 1.850045648952038e-07 6.732817555465426 -0.3005775153334347 DLSTVEALQNLK(ub)NLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLSTVEALQNLKNLK 15 1 Q9BTT0;E9PPH5;Q9BTT0-3 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 123011000.0 28293000.0 51327000.0 43391000.0 True False 27394854.20180519 71822138.76676908 32025595.397902586 1.0 2.621738310329695 1.1690368987542286 24.70740158970641 -6.619809918664679 2.1179422058353916 2.076233481513694 1.1746285030364978 0.0820129270718638 0.6974425075465728 0.5858930725181242 4.993973923838813 0.27064044935832476 0.7731245236479101 2.3998830662879487e-07 6.619809918664679 -0.9016049784771962 DLSTVEALQNLK(ub)NLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLSTVEALQNLKNLK 15 1 Q9BTT0;E9PPH5;Q9BTT0-3 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 184628000.0 32216000.0 46412000.0 106000000.0 True False 48874027.30508054 38129415.98138883 85049053.53854963 1.0 0.7801570298960243 1.7401687200372913 25.542564654281637 -6.846473367101574 1.2519810420280657 0.8829481421247055 1.7760150548953682 0.9350173602654893 0.10468516421405814 0.16137768295702926 0.4885437571525377 0.06548443871101862 0.15123313475109404 1.4240545734244857e-07 6.846473367101574 0.8930669127706626 DLSTVEALQNLK(ub)NLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLSTVEALQNLKNLK 15 1 Q9BTT0;E9PPH5;Q9BTT0-3 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 92937000.0 12476000.0 51559000.0 28902000.0 True False 17088714.35122284 49280952.8971872 22075942.855374508 1.0 2.8838303388025643 1.2918434003664407 24.026540525890002 -6.6049884259093705 2.1723899815486885 2.2627982445744705 1.2972952641128572 0.03509891402779031 0.8132176949860755 0.6265689228063719 5.595819037720122 0.3099381896561544 0.9035600078994408 2.4831992824904737e-07 6.6049884259093705 -0.9655029804616133 DLSTVEALQNLK(ub)NLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLSTVEALQNLKNLK 15 1 Q9BTT0;E9PPH5;Q9BTT0-3 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 102339370.0 28293000.0 41469370.0 32577000.0 True False 23526883.092420258 41245966.27278454 39388700.08097051 1.0 1.7531419742580734 1.6741996772900407 24.487806865140687 -10.25746508870627 4.708672730558044 0.9997726139700095 1.7136708257755047 0.9909067798017529 0.03222805778953249 7.702182528865536e-05 1.2146038068686255e-05 0.031214439253057707 0.01040156092395647 5.5275784027439e-11 10.25746508870627 0.7138982118054952 DLSYCLSGMYDHR ddPTM_RPMI8226_Bortezomib_1h_R1 2 DLSYCLSGMYDHR 13 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 109207800.0 28643100.0 40545800.0 40018900.0 False True 37551381.48017494 34496524.68629056 35878128.11639521 1.0 0.9186486176148494 0.9554409638787028 25.162362648327534 -10.20495477202425 4.393766950041499 1.0000201091393397 0.9370447907459103 0.7960763207778467 0.015020412469782503 2.9761023377216997e-06 5.385103652874875e-07 0.014548122455523902 0.004847817278295279 6.237997953982519e-11 10.20495477202425 -0.0629753183934294 DLSYCLSGMYDHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLSYCLSGMYDHR 13 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 29735500.0 15251800.0 1519900.0 12963800.0 False True 14767639.957413228 2126803.99617379 9568191.874336373 1.0 0.14401786624721663 0.6479161126577455 23.81593594909643 -10.129455564760109 5.686381075972963 1.0000067734984721 0.3959669896104696 0.6570535162488329 0.20571559766502873 1.7665416974814246e-05 2.7043341430317794e-06 0.19918550579550165 0.06639442365095219 7.422401368371162e-11 10.129455564760109 -0.6040397838880025 DLSYCLSGMYDHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLSYCLSGMYDHR 13 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 15027000.0 0.0 9769500.0 5257500.0 False True 0.0 8026056.395548115 4218352.820555893 0.0 DLSYCLSGMYDHR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DLSYCLSGMYDHR 13 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 82319900.0 28643100.0 24966500.0 28710300.0 False True 39233228.12067254 23863397.476825118 21929518.447189067 1.0 0.6082445574813957 0.5589526913191754 25.225572709850425 -13.999999999999998 0.2922978908079739 4.419844812185822 0.5458287880554508 0.9996326058402143 0.0037821760968126854 16.103805783590843 0.17150077138000017 33.16029264198218 0.01842515626268512 1.0000000000000041e-14 13.999999999999998 -3.874016024130371 DLTDYLMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 DLTDYLMK 8 0 P60709;A0A2R8Y793;P63267-2;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8;P68133;P68032;P63267;P62736;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 299025600.0 23886100.0 127967100.0 147172400.0 False True 31314908.413321413 108874907.49184908 131944411.82534671 1.0 3.476775536266091 4.21346951055483 24.900346323711773 -9.53133860378694 0.3558459840108081 1.0571409587458321e-19 4.380181390176065 0.9984464831155607 0.05417590406820378 0.8847997469808097 0.14589879306281323 1.293153825424044 0.21170812669773836 2.942126868844232e-10 9.53133860378694 4.380181390176065 DLTDYLMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 DLTDYLMK 8 0 P60709;A0A2R8Y793;P63267-2;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8;P68133;P68032;P63267;P62736;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 256724900.0 91563500.0 35728300.0 129433100.0 False True 88656866.81182602 49994796.51062312 95530688.20023182 1.0 0.5639134148146353 1.0775328706686136 26.401729041886 -6.681728377990456 1.8955336124999516 0.7245160518553205 1.0756152296725534 0.33214409435579073 0.18475376089564935 0.43469657036291487 3.02116641943705 0.0781628668281779 0.20571003337994329 2.0809978044435927e-07 6.681728377990456 0.3510991778172329 DLTDYLMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 DLTDYLMK 8 0 P60709;A0A2R8Y793;P63267-2;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8;P68133;P68032;P63267;P62736;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 682091800.0 35624600.0 631984000.0 14483200.0 False True 54045122.70711987 519201517.48647076 11620589.171787923 1.0 9.606815406824333 0.2150164268247102 25.687661092277974 -6.665696228240868 1.952978717232379 6.513893110361872 0.2538592484324743 0.26005059271505593 3.659649101958966 0.47103119355265316 3.4594459283191616 1.510959623232999 4.0591820334064925 2.1592541937123872e-07 6.665696228240868 -6.260033861929398 DLTDYLMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DLTDYLMK 8 0 P60709;A0A2R8Y793;P63267-2;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8;P68133;P68032;P63267;P62736;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 319822700.0 23886100.0 165581400.0 130355200.0 False True 32717436.66758125 158265466.243533 99567986.50961566 1.0 4.83734309174513 3.0432697867273526 24.963556385234664 -9.753930378225448 13.53366612402856 0.999969105786634 3.9403064392362417 0.7817224672971073 0.7324273599575497 0.0 0.0 0.7091697417574273 0.23638991391914238 1.762258531539755e-10 9.753930378225448 2.940337333449608 DLTDYLMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DLTDYLMK 8 0 P60709;A0A2R8Y793;P63267-2;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8;P68133;P68032;P63267;P62736;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 127685700.0 91563500.0 23028700.0 13093500.0 False True 76139107.2008209 22904639.82226095 15831290.312496163 1.0 0.30082622011640825 0.20792587271532229 26.182134317320276 -13.999999999999998 0.2844714645268643 6.8410628466344106 0.18116984612502676 0.9996151109215039 0.006935772328887989 15.645381211851921 0.16903009858751197 53.30726302638498 0.03598556115461406 1.0000000000000041e-14 13.999999999999998 -6.659893000509384 DLTDYLMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DLTDYLMK 8 0 P60709;A0A2R8Y793;P63267-2;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8;P68133;P68032;P63267;P62736;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 115752700.0 35624600.0 41116100.0 39012000.0 False True 46116746.9658504 38827952.89104336 31912216.296923142 1.0 0.8419490845656478 0.6919875836115293 25.458787414370423 -6.971762260684821 0.21191090465188844 1.0766245660652085 0.45311672499318817 0.999993057501843 0.00033130994630880774 0.07573492201537795 0.006945842572867589 0.004423267965487886 0.015471679523443064 1.0671801517882804e-07 6.971762260684821 -0.6235078410720203 DLTDYLMK(ub)ILTER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLTDYLMKILTER 13 1 P60709;A0A2R8Y793;P63267-2;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8;P68133;P68032;P63267;P62736;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 1 159964000.0 32634000.0 42600000.0 84730000.0 True False 31598051.53294847 59610402.156065285 62536671.154485546 1.0 1.8865214550937512 1.9791306147240193 24.913332262790462 -11.016665015224806 0.4083604625033983 4.458257327331368e-12 1.9851755573908794 0.9995535220621062 0.009325960910167339 2.836621210184011 0.20013694782592353 2.6828872582319447 0.023110520668235175 9.623542858254978e-12 11.016665015224806 1.9851755573864212 DLTDYLMK(ub)ILTER ddPTM_RPMI8226_Bortezomib_8h_R1 2 DLTDYLMKILTER 13 1 P60709;A0A2R8Y793;P63267-2;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8;P68133;P68032;P63267;P62736;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 1 1097440000.0 146092000.0 364590000.0 586758000.0 True False 221632244.75583026 299526065.9453278 470785024.1148322 1.0 1.3514552734657914 2.1241720699688384 27.723592550076123 -6.958152058264536 0.46074505197802873 0.9776434699865566 2.52917219645335 0.9996953831155975 0.008195349626720909 0.08036805779152442 0.023621829200559826 0.010507715541064996 0.06382898705737569 1.1011536982953444e-07 6.958152058264536 1.5515287264667934 up DLTDYLMK(ub)ILTER ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DLTDYLMKILTER 13 1 P60709;A0A2R8Y793;P63267-2;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8;P68133;P68032;P63267;P62736;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 1 1216912300.0 146092000.0 272115000.0 798705300.0 True False 189118973.9038477 256971561.04169062 653349130.808441 1.0 1.3587825469714143 3.454699004133865 27.494718872168573 -6.936402874715227 0.6922152586618812 0.9743819482676191 3.9647204226977775 0.9976538241641788 0.052435611105052814 0.08944657953407446 0.062373104969770075 0.04974528684602936 0.18343143557198954 1.15770291093432e-07 6.936402874715227 2.990338474430158 up DLTEYLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLTEYLSR 8 0 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 6526710.0 2687300.0 711910.0 3127500.0 False True 2601993.1324536502 996179.3755616065 2308313.927011136 1.0 0.38285242306624406 0.8871329821053071 21.311185723621183 -10.131576481466984 7.483667393850328 1.0000001156934508 0.6349927025858007 0.411262481910336 0.20587167614185864 3.972508990387988e-07 4.604114716659756e-08 0.19933445566410968 0.06644479776276879 7.38624176065611e-11 10.131576481466984 -0.36500741310765017 DLTGELEYATK(ub)ISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLTGELEYATKISR 14 1 Q9GZP4-2;Q9GZP4;X6R8S9;X6RHB9 Q9GZP4-2 PITHD1 PITH domain-containing protein 1 1 10865100.0 1800500.0 6275900.0 2788700.0 True False 1743344.113043873 8781899.598386144 2058255.8107932734 1.0 5.037387359546003 1.1806365681870836 20.733425935794273 -6.6354469716573234 2.0607335409058227 3.6492655552515565 1.1964532405302633 0.13742220243248338 1.7294516963270916 0.5449635711035551 4.417157448819781 0.6847489227394719 1.9153860040778194 2.315010836840123e-07 6.6354469716573234 -2.4528123147212932 DLTGELEYATK(ub)ISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLTGELEYATKISR 14 1 Q9GZP4-2;Q9GZP4;X6R8S9;X6RHB9 Q9GZP4-2 PITHD1 PITH domain-containing protein 1 1 17862100.0 4238200.0 6088600.0 7535300.0 True False 6429659.253923279 5002041.759551075 6045944.652160676 1.0 0.7779637399134186 0.9403211606387281 22.616310851869454 -10.237894933922956 5.194731490819836 1.000015482757899 0.8591424503704379 0.500894959434002 0.06628213945536604 1.1886604289482471e-05 1.7438435702373607e-06 0.06418445734816929 0.021392468521782917 5.782359193911821e-11 10.237894933922956 -0.14087303238746118 DLTGELEYATK(ub)ISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLTGELEYATKISR 14 1 Q9GZP4-2;Q9GZP4;X6R8S9;X6RHB9 Q9GZP4-2 PITHD1 PITH domain-containing protein 1 1 9086700.0 1800500.0 4413200.0 2873000.0 True False 1497195.5256742912 4389425.215648383 3473731.016748878 1.0 2.93176484993269 2.3201585612436397 20.51383121122855 -10.080301649018251 5.199613928628554 0.9999731444558192 2.625961705591065 0.9040635823232155 0.24968722180437486 7.773383297108247e-05 1.3749799567774029e-05 0.24176257879409854 0.08058620431597159 8.311862514214054e-11 10.080301649018251 1.6259885611352458 DLTGELEYATK(ub)ISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLTGELEYATKISR 14 1 Q9GZP4-2;Q9GZP4;X6R8S9;X6RHB9 Q9GZP4-2 PITHD1 PITH domain-containing protein 1 1 24887500.0 4238200.0 6521400.0 14127900.0 True False 5486433.4474118175 6158478.357228673 11556767.164495567 1.0 1.1224921283122258 2.1064262011502906 22.387437173961903 -6.930019821925932 0.7466284462629518 0.9850489225087918 2.308525613740647 0.996542211256617 0.02912122118872104 0.09262725620939787 0.07762925756979837 0.02653409092770185 0.08901912633672134 1.1748439318754054e-07 6.930019821925932 1.3234766912318552 up DLTLEENQVK(ub)KYHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLTLEENQVKKYHR 14 2 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 162221400.0 23083000.0 73464100.0 65674300.0 True False 30262036.53608994 62503542.6408189 58878953.42836944 1.0 2.06541098337114 1.9456375104878185 24.85100574369127 -10.091079956093953 4.710732072694641 0.9999489479851557 2.005524246943479 0.9894706784352018 0.04889731561327799 17003348.472699568 1.1458627413729903 9695.088830648387 0.01673885171682462 8.108117690353613e-11 10.091079956093953 1.0055752989583233 DLTLEENQVK(ub)KYHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLTLEENQVKKYHR 14 2 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 281871800.0 52334000.0 83838800.0 145699000.0 True False 50672685.81618333 117316070.05356622 107536061.02369185 1.0 2.31517371072719 2.122170145347774 25.594704962600268 -10.14252667303705 4.757603846382126 0.9999003216333031 2.2186719280428187 0.9815360518832712 0.07879337565830295 27538967.550723065 6.172064873859168 30613.959411199234 0.02697306826287814 7.202335153431432e-11 10.14252667303705 1.2187716064095155 DLTLEENQVK(ub)KYHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLTLEENQVKKYHR 14 2 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 749722000.0 161670000.0 341016000.0 247036000.0 True False 245265209.66018033 280159030.42983073 198209226.3202748 1.0 1.142269752885036 0.8081424454568893 27.869767364334148 -6.790982127389051 1.4921838539061634 1.079410867179272 0.8044801541389924 0.80458422545805 0.06052078998028176 0.23387416846655834 1.02869504734633 0.03192122985430029 0.07468949481982896 1.6181466281968762e-07 6.790982127389051 -0.2749307130402795 DLTLEENQVK(ub)KYHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLTLEENQVKKYHR 14 2 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 146251300.0 23083000.0 45438300.0 77730000.0 True False 31617408.894619785 43430685.661635496 59371774.89960069 1.0 1.373632033111541 1.8778191184953097 24.914215805214162 -6.966955522620723 0.32273242212317566 0.9331286606780708 2.334650462497183 0.9999479663814175 0.00259457091906757 0.07730348532854159 0.012552539701062817 0.007559703416763376 0.04424370359373047 1.0790572260054951e-07 6.966955522620723 1.4015218018191122 DLTLEENQVK(ub)KYHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLTLEENQVKKYHR 14 2 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 213048100.0 52334000.0 84328100.0 76386000.0 True False 43518039.789302066 83873807.78748278 92357959.43104076 1.0 1.927334231816693 2.122291350396368 25.375110238034544 -10.77268716468548 0.30773003210006133 5.646431706600468e-13 2.1773753886045593 0.9991846413626797 0.013980668506561388 2.4800064540637083 0.15346614202902567 1.8959762154733364 0.06781960731557019 1.6877683376748116e-11 10.77268716468548 2.177375388603995 DLTLEENQVK(ub)KYHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLTLEENQVKKYHR 14 2 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 724187000.0 161670000.0 381547000.0 180970000.0 True False 209285001.99213538 360313574.0432311 148035316.909007 1.0 1.7216406842988738 0.70733839262199 27.640893686426597 -6.715644341298501 1.7746754270265095 1.4410825111796737 0.7092684660461276 0.49187360377169853 0.3038459229974436 0.3639303391177819 2.237500871341729 0.13606236880355638 0.34337014469590715 1.924667259968241e-07 6.715644341298501 -0.7318140451335461 DLTSVNILLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLTSVNILLK 10 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;O15020;O15020-2 Q01082;O15020 SPTBN1;SPTBN2 Spectrin beta chain, non-erythrocytic 1;Spectrin beta chain, non-erythrocytic 2 0 9117100.0 1814000.0 4255400.0 3047700.0 False True 2378171.566800986 3620510.9074192857 2732353.2396027287 1.0 1.5223926473435394 1.1489302444559004 21.18142136752148 -10.060453924338479 8.721996309941986 0.9999999977202799 1.3356614459005072 0.5185548495358135 0.15246538753140507 6.450322872737857e-09 6.305232778289035e-10 0.14762397669554767 0.04920799223184932 8.700537348940806e-11 10.060453924338479 0.33566144818022725 DLTSVNILLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLTSVNILLK 10 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;O15020;O15020-2 Q01082;O15020 SPTBN1;SPTBN2 Spectrin beta chain, non-erythrocytic 1;Spectrin beta chain, non-erythrocytic 2 0 8643200.0 2233000.0 1499900.0 4910300.0 False True 2162114.637282402 2098817.8918751674 3624145.1241575694 1.0 0.9707246117686003 1.6762039633165882 21.044011587426464 -6.897219442590406 0.9786874960239953 0.968388135092409 1.7462103505731141 0.9851307297640232 0.03973830554846064 0.11348176778823096 0.1891929146844484 0.030605225549841804 0.0785740766520263 1.2670115018806752e-07 6.897219442590406 0.7778222154807052 DLTSVNILLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLTSVNILLK 10 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;O15020;O15020-2 Q01082;O15020 SPTBN1;SPTBN2 Spectrin beta chain, non-erythrocytic 1;Spectrin beta chain, non-erythrocytic 2 0 14302300.0 3431700.0 7812500.0 3058100.0 False True 5206139.790875495 6418298.335658901 2453665.194587157 1.0 1.232832500369638 0.4713022110715422 22.31178261961695 -6.824641777512091 1.3515789534721792 1.1249437255908634 0.4529502712115266 0.894743190786707 0.10337042905610393 0.18752030591583177 0.6717828103224597 0.06007881860083966 0.13833730033604746 1.4974703168898102e-07 6.824641777512091 -0.6719934543793369 down DLTSVNILLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLTSVNILLK 10 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;O15020;O15020-2 Q01082;O15020 SPTBN1;SPTBN2 Spectrin beta chain, non-erythrocytic 1;Spectrin beta chain, non-erythrocytic 2 0 10682500.0 1814000.0 3333400.0 5535100.0 False True 2484684.8215067494 3186119.365920285 4227823.3789628185 1.0 1.282303227492723 1.7015531879005097 21.24463142904437 -6.965422827939555 0.350724840320486 0.9598209291542904 2.038198120296347 0.9999215922009642 0.002552138629283446 0.07781781610268136 0.014356000465495138 0.0057443354440870195 0.036018410218503626 1.0828721192489066e-07 6.965422827939555 1.0783771911420565 DLTSVNILLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLTSVNILLK 10 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;O15020;O15020-2 Q01082;O15020 SPTBN1;SPTBN2 Spectrin beta chain, non-erythrocytic 1;Spectrin beta chain, non-erythrocytic 2 0 6929500.0 2233000.0 2108300.0 2588200.0 False True 1856838.4386729733 2096942.169435217 3129380.6535153016 1.0 1.1293078200889888 1.6853273760057317 20.82441686286074 -6.943217388024951 0.6289264184534329 0.9939346593460925 1.8506115011822781 0.9985556054971775 0.011299412226139767 0.0863291545997226 0.04815364538240827 0.011288461938513732 0.047219344574195056 1.1396791733073215e-07 6.943217388024951 0.8566768418361856 DLTTAGAVTQCYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLTTAGAVTQCYR 13 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 80711000.0 12644000.0 36019000.0 32048000.0 False True 16576406.44467019 30645105.60096236 28731980.386123437 1.0 1.8487182793961763 1.7333057368029021 23.98262794689746 -10.352093141507837 5.5720036667244 0.9998058918881668 1.7910120080995464 0.9842847287384793 0.047116973211817244 0.00011364174645154724 1.3214177188611418e-05 0.0456317214791528 0.015206937714418736 4.445359192945089e-11 10.352093141507837 0.7912061162113796 DLTTAGAVTQCYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLTTAGAVTQCYR 13 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 30964200.0 17520000.0 4207200.0 9237000.0 False True 16963837.18996316 5887156.900258157 6817552.595939851 1.0 0.347041582298453 0.4018874102360244 24.01595920609253 -10.566359952075883 9.899777275855389 1.0000318648641415 0.37446449827895767 0.994267450942367 0.02239071549458877 1.574813293212099e-05 6.898524336592739e-07 0.02168080981344496 0.007226572351684249 2.7141887616343267e-11 10.566359952075883 -0.6255673665851839 DLTTAGAVTQCYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLTTAGAVTQCYR 13 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 88041600.0 4857200.0 77857000.0 5327400.0 False True 7368727.50888495 63962810.05048243 4274437.054917627 1.0 8.680306060084098 0.5800780460077622 22.812984073973702 -6.6582467022586185 1.9792328694766166 5.951024050734784 0.6141631229917853 0.22801985198851304 3.2715179436888984 0.488696986582647 3.6783308962142236 1.3363211392012422 3.6256843784170996 2.1966117265556942e-07 6.6582467022586185 -5.336860927742999 DLTTAGAVTQCYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLTTAGAVTQCYR 13 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 66196000.0 12644000.0 27408000.0 26144000.0 False True 17318828.49125215 26197023.93386425 19969325.652581494 1.0 1.5126325632877844 1.1530413655096894 24.04583800842035 -9.949808602644023 8.344753670214516 0.9999999994266261 1.332836964398737 0.5332140082938618 0.14680249175876015 1.4901243041824392e-09 2.5381990952653585e-10 0.14214090249988967 0.047380300480285784 1.1225130465724424e-10 9.949808602644023 0.3328369649721109 DLTTAGAVTQCYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLTTAGAVTQCYR 13 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 24163300.0 17520000.0 1903900.0 4739400.0 False True 14568656.267599883 1893643.3128054403 5730386.627490311 1.0 0.12998064324002404 0.39333666209384494 23.796364481526805 -10.228321925486032 5.415343532263251 1.000048905231553 0.2616586528859389 0.9128929629848727 0.10751464448069954 6.348628642600793e-05 9.04668250889676e-06 0.10410746270308781 0.03470020229555932 5.911232951922023e-11 10.228321925486032 -0.7383902523456142 DLTTAGAVTQCYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLTTAGAVTQCYR 13 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 24865700.0 4857200.0 11481000.0 8527500.0 False True 6287741.149725996 10842072.257389896 6975582.4995389255 1.0 1.7243191154366089 1.1093940309299952 22.58411039606615 -10.261261825532896 4.559220786673254 0.9998213857052647 1.4168565731857512 0.3799325808479135 0.25104211452151803 0.00045597322141748556 7.388207976900685e-05 0.24317375990764373 0.08102349406036942 5.4794652175171595e-11 10.261261825532896 0.4170351874804865 DLVEAVAHILGIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLVEAVAHILGIR 13 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 3805390000.0 1249140000.0 1453760000.0 1102490000.0 False True 1895036704.3664105 1194325169.7212763 884582368.2614665 1.0 0.6302385420659115 0.466789042250883 30.819578645757076 -13.999999999999977 0.11071672457901008 2.7819530862982735 0.1700173102625131 0.999739423451573 0.003600519770201235 12.008474189272167 0.10108711960095093 4.777106882554009 0.2635496798464731 1.0000000000000532e-14 13.999999999999977 -2.6119357760357604 DLVEAVAHILGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLVEAVAHILGIR 13 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 2106928000.0 1249140000.0 379016000.0 478772000.0 False True 1617036354.230568 357923426.4181595 391640408.6155666 1.0 0.22134531823093717 0.2421964154305735 30.590704967849526 -10.229180536957589 8.176150399134723 1.000000382961262 0.23177086715431586 0.9994477981478705 0.008512424786047372 5.9420468849746056e-08 5.618005939820138e-09 0.008242123910585682 0.002747373286017064 5.899557835638208e-11 10.229180536957589 -0.7682295158069462 DLVLSVHNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLVLSVHNR 9 0 A0A499FI31;Q15020-4;Q15020 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 20839000.0 6860700.0 8170500.0 5807800.0 False True 8994444.13911332 6951493.248359556 5206864.568351453 1.0 0.7728652422366192 0.5788978715992948 23.100602694322422 -6.972959614582475 0.17348976802698365 1.1635295758751416 0.1830217044687737 0.9999972178710479 0.0002869862866505976 0.07535348941917035 0.005431985766203783 0.007917960709794343 0.0222163506553739 1.0642419784002592e-07 6.972959614582475 -0.980507871406368 DLVLSVHNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLVLSVHNR 9 0 A0A499FI31;Q15020-4;Q15020 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 16589500.0 6886000.0 1884700.0 7818800.0 False True 6667407.699205836 2637270.5385806574 5770821.721027876 1.0 0.3955466138503554 0.8655270505979777 22.668694517173908 -9.954498733703423 6.784629317703833 1.0000000298011207 0.6305368322241928 0.45175111400526935 0.19186870985368484 8.648702587901981e-08 1.3464734192348147e-08 0.1857760933217584 0.06192535982680084 1.1104557731465839e-10 9.954498733703423 -0.3694631975769279 DLVLSVHNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DLVLSVHNR 9 0 A0A499FI31;Q15020-4;Q15020 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 16110300.0 6243700.0 6091500.0 3775100.0 False True 9472149.37561247 5004424.231893272 3028949.8303148914 1.0 0.5283303750232176 0.3197742888338941 23.175260401743326 -12.462107087274093 0.12884864171868138 2.542317993142966 7.678592427858843e-17 0.999698394148115 0.004941573212676795 6.721414227294067 0.0956771265778109 2.970822353373709 0.2546365932695771 3.4505864512601694e-13 12.462107087274093 -2.542317993142966 DLVLSVHNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLVLSVHNR 9 0 A0A499FI31;Q15020-4;Q15020 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 20441400.0 6860700.0 6522500.0 7058200.0 False True 9397286.193446193 6234314.382976852 5391198.528191961 1.0 0.6634164645666273 0.5736973863743624 23.163812755845314 -13.999999999999998 0.1855807592745011 2.7776060368153974 0.5063895837752986 0.9994924570315356 0.004134162764155813 12.282032199491107 0.13660029960045061 7.883946497175909 0.06394043798149086 1.0000000000000041e-14 13.999999999999998 -2.2712164530400987 DLVTTLGGALLWLSGHAGTQAQGAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLVTTLGGALLWLSGHAGTQAQGAAR 26 0 C9JGI3;P19971;P19971-2;A0A494C1N7;A0A494C0L6 C9JGI3 TYMP Thymidine phosphorylase 0 2046280000.0 1108100000.0 446730000.0 491450000.0 False True 1434457293.9165292 421869082.7927692 402011142.70283216 1.0 0.29409664866420043 0.2802531273728008 30.417857871397842 DLVVGTEAK(ub)LNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLVVGTEAKLNK 12 1 P36956;P36956-4;P36956-3;P36956-2;P36956-6;P36956-5 P36956 SREBF1 Sterol regulatory element-binding protein 1;Processed sterol regulatory element-binding protein 1 1 27562400.0 2480900.0 16726000.0 8355500.0 True False 3211573.9558501174 15795183.396664353 6834884.734669882 1.0 4.918206341750987 2.1282040608841153 21.614849088409173 -6.558030001589095 2.3545451314379857 3.702444554976682 2.132386639479189 0.0 1.7116004153440898 0.7678394015442938 7.9754571597144075 0.61925916335366 1.926768821851973 2.7667505083316903e-07 6.558030001589095 -1.5700579154974927 DLVVPEK(ub)WEESGPQFITNSEEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLVVPEKWEESGPQFITNSEEVR 23 1 Q13257 Q13257 MAD2L1 Mitotic spindle assembly checkpoint protein MAD2A 1 15698200.0 4732400.0 4248400.0 6717400.0 True False 4582172.552384793 5944808.275113317 4957911.422319618 1.0 1.2973776537549508 1.0820001572702171 22.12760035703323 -10.31381317500752 3.685061383781762 0.999440446073877 1.189688905435681 0.5084162717206515 0.08792749498296105 20550144.56179882 86.8759025184579 97920.15294186595 0.031296406795039616 4.8549730669297356e-11 10.31381317500752 0.1902484593618039 DLVVPEK(ub)WEESGPQFITNSEEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLVVPEKWEESGPQFITNSEEVR 23 1 Q13257 Q13257 MAD2L1 Mitotic spindle assembly checkpoint protein MAD2A 1 14624600.0 4732400.0 5157200.0 4735000.0 True False 3935200.2808669875 5129417.139975949 5725066.607833603 1.0 1.3034704141782223 1.4548348747759998 21.908005632467507 -12.057883255660476 0.10975883718646462 6.32814299428203e-16 1.7660935223806693 0.999807143445822 0.002626286287951924 5.7622491777318485 0.08022131280395765 1.568077526278743 0.23561930374304743 8.752190145362545e-13 12.057883255660476 1.7660935223806686 DLVVPEK(ub)WEESGPQFITNSEEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLVVPEKWEESGPQFITNSEEVR 23 1 Q13257 Q13257 MAD2L1 Mitotic spindle assembly checkpoint protein MAD2A 1 25829500.0 7491100.0 5417400.0 12921000.0 True False 9697376.621656988 5115916.927722678 10569510.5806558 1.0 0.5275567947208925 1.089935040477967 23.209163084993886 -6.683919234765549 1.8878061981925112 0.7021316221626911 1.0878694662071 0.3421124886026845 0.20006471379727478 0.429937152872772 2.9656131624258064 0.08492987588256792 0.2228912308744039 2.070526366344533e-07 6.683919234765549 0.3857378440444089 DLWYLETEK(ub)PPPPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DLWYLETEKPPPPAR 15 1 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 12003200.0 3127200.0 5265400.0 3610600.0 True False 4099789.4838478793 4479822.84436845 3237009.7473208057 1.0 1.0926958230459893 0.7895551125426794 21.967118401394888 -6.824635028017249 1.3516732618783198 1.0497423967969226 0.782254274403413 0.8947187112131781 0.04115280190324897 0.18752665710548097 0.6719116336885562 0.02391676606339757 0.0550689366207455 1.4974935896854382e-07 6.824635028017249 -0.2674881223935096 DLWYLETEK(ub)PPPPAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLWYLETEKPPPPAR 15 1 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 13784700.0 4447600.0 3741700.0 5595400.0 True False 4306413.372493157 5235780.322707727 4129796.8815981215 1.0 1.2158099722035094 0.9589875667711887 22.038055379730903 -6.683884677792865 1.888441056427922 1.1360683086145378 0.9599414776571038 0.3418703847645127 0.09138892836073097 0.4299280051410046 2.967653927372478 0.03878792582285549 0.10178095951916333 2.070691125448813e-07 6.683884677792865 -0.17612683095743398 DLWYLETEK(ub)PPPPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DLWYLETEKPPPPAR 15 1 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 11449900.0 3127200.0 3947600.0 4375100.0 True False 4283410.34940238 3773181.979032492 3341791.4880129006 1.0 0.8808826778781362 0.7801707554073464 22.03032846291778 -6.973067692698882 0.16958443602687936 1.0894805507702205 0.568876868876247 0.9999974852546905 0.00014236617809447325 0.07531923488045693 0.005287392316383587 0.004260519397102434 0.01168461555941059 1.0639771650941652e-07 6.973067692698882 -0.5206036818939735 DLWYLETEK(ub)PPPPAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLWYLETEKPPPPAR 15 1 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 11562600.0 4447600.0 4064400.0 3050600.0 True False 3698376.462087741 4042504.270479767 3688466.3556192624 1.0 1.0930483448398773 0.9973204170613599 21.81846065516518 -6.652677499959821 1.999025749772015 1.0602528641007936 0.9977237831248679 0.204858412513499 0.03968849243871507 0.502076596679416 3.848747878877197 0.0160849354424334 0.043965558412875964 2.2249614976776485e-07 6.652677499959821 -0.06252908097592569 DLWYLETEK(ub)PPPPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLWYLETEKPPPPAR 15 1 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 38728000.0 4509100.0 2540900.0 31678000.0 True False 5837118.837649157 2399496.681369391 25912929.043728366 1.0 0.41107552340595566 4.439335529129735 22.476825009609062 -6.869753835057478 1.1353435176146964 0.667388659137626 4.674203495711856 0.9644396578667822 0.3349977010239051 0.13709392582043914 0.3304264715862292 0.22901868066436407 0.5420025154941001 1.349727712707132e-07 6.869753835057478 4.00681483657423 up DLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Bortezomib_1h_R1 2 DLYANTVLSGGTTMYPGIADR 21 0 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 121628700.0 37709800.0 58442900.0 25476000.0 False True 49437912.98222272 49723447.12863998 22839987.9030479 1.0 1.005775610845869 0.46199336754488174 25.559114505476686 -6.904501955311948 0.9323902988978302 1.0199015369080666 0.3994000429604831 0.9886754503793499 0.027135341187347548 0.10816626540891047 0.15932946457197894 0.021629007945551938 0.0576573228393351 1.2459426276853328e-07 6.904501955311948 -0.6205014939475835 down DLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Bortezomib_2h_R1 2 DLYANTVLSGGTTMYPGIADR 21 0 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 572156900.0 213734200.0 86763800.0 271658900.0 False True 206949324.8131862 121409037.80723977 200503284.49769014 1.0 0.5866607098952176 0.9688520833720288 27.62470230078014 -10.467188717687227 8.822711065536895 1.0000044257744412 0.7777563985592335 0.3107505685215495 0.15602897485194397 1.3583429432887545e-05 8.203651932292956e-07 0.15107741393916932 0.050358135093949576 3.4104468236250297e-11 10.467188717687227 -0.22224802721520764 DLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Bortezomib_8h_R1 2 DLYANTVLSGGTTMYPGIADR 21 0 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 1473794500.0 200516000.0 1031928000.0 241350500.0 False True 304197431.68318605 847772385.9097357 193647467.88731804 1.0 2.7869150019408093 0.6365848219553576 28.180432731643318 -6.68608607140051 1.8801119136714552 2.1243350100378953 0.6442925141941516 0.3523107085772613 0.7563448840676652 0.4251085774624264 2.910216017542337 0.3221821232755551 0.8432129106508954 2.060221564244648e-07 6.68608607140051 -1.4800424958437437 DLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DLYANTVLSGGTTMYPGIADR 21 0 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 107249300.0 37709800.0 22122700.0 47416800.0 False True 51652132.12902725 21145245.964014117 36217928.419649854 1.0 0.40937798871870773 0.7011894171024211 25.622324566999577 -10.50739215106144 6.3419878369303655 1.000334172000512 0.5552837029105859 0.7559015578135493 0.11913151677546903 0.0005633001246655951 4.375363176100275e-05 0.1154325104013129 0.038449531706651725 3.1089078461946616e-11 10.50739215106144 -0.44505046908992596 DLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DLYANTVLSGGTTMYPGIADR 21 0 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 403839100.0 213734200.0 85545900.0 104559000.0 False True 177729457.3305049 85085047.25716835 126421803.47380655 1.0 0.47873351179452817 0.7113159820136801 27.405107576214416 -10.340168532865933 5.841060032989236 1.0000566647887883 0.5950247469041045 0.8016826406017399 0.09495139585883462 7.007585196381454e-05 7.916266280810822e-06 0.09194910332965302 0.030645431238367365 4.569108458062554e-11 10.340168532865933 -0.40503191788468385 DLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DLYANTVLSGGTTMYPGIADR 21 0 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 760094000.0 200516000.0 338924000.0 220654000.0 False True 259571914.76127294 320062581.4618595 180497236.10123256 1.0 1.2330401066549113 0.6953650446629983 27.951559053735767 -6.788894151859567 1.5006123830557665 1.130432236145137 0.6898081821531082 0.7977730936652241 0.09900185773426541 0.2369979200451382 1.0543033646465658 0.05193147242533805 0.12169006128413183 1.6259449898488201e-07 6.788894151859567 -0.44062405399202886 DLYDAGVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLYDAGVKR 9 1 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33 P07355 ANXA2 Annexin A2;Annexin 1 1519600.0 0.0 1519600.0 0.0 True False 0.0 2126384.2046093117 0.0 0.0 DLYDAGVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLYDAGVKR 9 1 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33 P07355 ANXA2 Annexin A2;Annexin 1 4034400.0 0.0 2823200.0 1211200.0 True False 0.0 2807990.861238675 1464456.3200439431 0.0 DLYDAGVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLYDAGVKR 9 1 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33 P07355 ANXA2 Annexin A2;Annexin 1 16757100.0 2960600.0 4325500.0 9471000.0 True False 3832555.0621507755 4084782.1225799136 7747375.180666436 1.0 1.065811725164776 2.021464807427638 21.869875088493608 -6.9208263005866435 0.8185760347999625 0.9795358386141997 2.1785395830956125 0.9944073945192158 0.034907922451873734 0.09768792348100779 0.10311302148673213 0.03020911791359266 0.09121783056647688 1.199979148060088e-07 6.9208263005866435 1.1990037444814128 up DLYEDELVPLFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DLYEDELVPLFEK 13 0 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 8678600.0 4460500.0 1140900.0 3077200.0 False True 4318903.869054261 1596467.3197149031 2271189.0059787915 1.0 0.369646412172747 0.5258716273479199 22.042233774458563 -10.368444139987393 8.86411641672269 1.0000013929770624 0.4477590197612046 0.9433771628796378 0.06377867702261349 1.755791659308766e-06 1.2498977300767452e-07 0.06175359395140688 0.020584479495976974 4.2811048065640927e-11 10.368444139987393 -0.5522423732158578 DLYIRPNIAQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DLYIRPNIAQKR 12 2 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 1 5535300.0 1056800.0 3169700.0 1308800.0 True False 878776.0241780569 3152624.1969638113 1582464.028792528 1.0 3.587517308420592 1.8007592210684737 19.745135983397734 -9.32343126798715 8.830667283296098 1.0000157986932168 2.6941382647445833 0.5451826066806995 0.7294409346924362 0.0 0.0 0.7062781480000362 0.23542604933334535 4.748634375038795e-10 9.32343126798715 1.6941224660513665 DLYIRPNIAQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DLYIRPNIAQKR 12 2 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 1 11629400.0 2733400.0 1746000.0 7150000.0 True False 3538440.1833692305 1648833.5651426495 5848773.365195334 1.0 0.4659775154295992 1.6529241875232865 21.7546821003548 -6.784367701727876 1.5186440585896246 0.6993474608910912 1.6636860033348901 0.78263996526902 0.22629271267234294 0.2438274012991318 1.1108933070410114 0.11732791461494965 0.2758758818629778 1.6429800812337486e-07 6.784367701727876 0.9643385424437989 DMAEAHK(ub)EAMSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DMAEAHKEAMSR 12 1 J3KN29;O00233;F5H5V4;F5GX23;O00233-2;F5H169 J3KN29 PSMD9 26S proteasome non-ATPase regulatory subunit 9 1 9719000.0 2562000.0 2820800.0 4336200.0 True False 2480670.7123678974 3947160.150277668 3200419.136788396 1.0 1.5911665061381521 1.2901426702190033 21.242298811945638 -10.095893972308158 4.675308991547486 0.9999738710793508 1.4406545881869235 0.7407414488572324 0.1228924664314492 85509000.1713912 0.36016150840546374 24052.64749398206 0.042069360003180935 8.018738071857544e-11 10.095893972308158 0.44068071710757273 DMAEAHK(ub)EAMSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DMAEAHKEAMSR 12 1 J3KN29;O00233;F5H5V4;F5GX23;O00233-2;F5H169 J3KN29 PSMD9 26S proteasome non-ATPase regulatory subunit 9 1 10957400.0 1818900.0 4813500.0 4325000.0 True False 2759404.2794018793 3954493.3169528455 3470161.854285162 1.0 1.4330967544233897 1.2575764559723537 21.395925410270568 -10.094016084895967 5.0680197225487875 0.9999911549913097 1.3453366051988618 0.8376997719463274 0.07165586178778334 7.16151178329361e-06 1.2801331311687263e-06 0.0693822652783243 0.02312682994635877 8.053486130776229e-11 10.094016084895967 0.34534545020755203 DMAEAHK(ub)EAMSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DMAEAHKEAMSR 12 1 J3KN29;O00233;F5H5V4;F5GX23;O00233-2;F5H169 J3KN29 PSMD9 26S proteasome non-ATPase regulatory subunit 9 1 4298900.0 1224400.0 1082600.0 1991900.0 True False 1677093.7681658596 1034767.1523205439 1521454.2444682193 1.0 0.6170001773080397 0.9071968862731783 20.67753192315548 -9.849294165780965 5.792663990114316 1.0000000513741765 0.7620985317900775 0.47259679894656004 0.11847231033514058 7.86168964762112e-08 1.563940891935078e-08 0.11471034686755828 0.03823677374261822 1.4148351284356835e-10 9.849294165780965 -0.237901519584099 DMAEAHK(ub)EAMSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DMAEAHKEAMSR 12 1 J3KN29;O00233;F5H5V4;F5GX23;O00233-2;F5H169 J3KN29 PSMD9 26S proteasome non-ATPase regulatory subunit 9 1 8115800.0 2562000.0 3772400.0 1781400.0 True False 2130416.5158442273 3752077.332437223 2153882.503737021 1.0 1.761194256865951 1.0110147418208004 21.022704087379914 -10.365602163352438 4.585563050335211 0.9995239708123622 1.3861044993440326 0.26100976676345 0.30625950456043416 0.0014922495192168685 0.00020644813754966632 0.2968924702471139 0.09884483006470868 4.309211762642997e-11 10.365602163352438 0.38658052853167035 DMAEAHK(ub)EAMSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DMAEAHKEAMSR 12 1 J3KN29;O00233;F5H5V4;F5GX23;O00233-2;F5H169 J3KN29 PSMD9 26S proteasome non-ATPase regulatory subunit 9 1 10774400.0 1818900.0 4962200.0 3993300.0 True False 2354601.905879229 4686049.207875625 3266560.374718116 1.0 1.9901662341200788 1.387308982703959 21.167051732363017 -10.725545023148335 6.673338300269016 0.9898486713294815 1.6887376084120187 0.6350728410729592 0.24611544228437413 0.03682208078738792 0.0015143829889232416 0.23606200294997193 0.07943341743432109 1.881286663815816e-11 10.725545023148335 0.6988889370825372 DMDLACK(ub)YSMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DMDLACKYSMK 11 1 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 63302400.0 3825400.0 18314000.0 41163000.0 True False 5803411.474200875 15045723.612064913 33027115.007616166 1.0 2.592565369343675 5.690982821817571 22.468469791984816 -6.960581102838393 0.4271654731617957 0.8731613663904022 7.528651856717553 0.99979114718263 0.028147637751351245 0.07949419596099777 0.020369151386534445 0.04029798817884794 0.25743838818573517 1.0950120469476064e-07 6.960581102838393 6.655490490327151 DMDLACK(ub)YSMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DMDLACKYSMK 11 1 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 10928900.0 1949100.0 3291100.0 5688700.0 True False 2669734.942446977 3145688.319787676 4345146.222454118 1.0 1.1782773899286265 1.6275571605889545 21.34826508419606 -6.955289591503867 0.4973958192722871 0.9907956238828133 1.8343311523354555 0.9995536624608861 0.005578331584643744 0.08142868279192249 0.02769087718521612 0.006574431749645081 0.03705868048877818 1.1084354539582413e-07 6.955289591503867 0.8435355284526422 DMDLACK(ub)YSMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DMDLACKYSMK 11 1 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 48362200.0 3825400.0 8890800.0 35646000.0 True False 4952055.709907318 8396019.16435869 29158793.75884657 1.0 1.6954613712364373 5.888220057886283 22.239596114077266 -6.935733515968871 0.6981237382595442 0.9477188299885366 6.889794146801614 0.9975500090088406 0.10687256715507218 0.08976797866951028 0.0638833117760815 0.10093354030293349 0.3681515285667558 1.1594886026299089e-07 6.935733515968871 5.942075316813077 DMEEGK(ub)AAFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DMEEGKAAFSK 11 1 A0A0D9SF98;A0A087WWJ5;A0A0D9SF30;A0A087WTF6;A0A087WX77;A0A087WWD4;A0A087WV75;P13591-1;P13591 A0A0D9SF98 NCAM1 Neural cell adhesion molecule 1 1 10858200.0 1498100.0 1471300.0 7888800.0 True False 1964023.6076210348 1251787.7750824797 7072542.650713009 1.0 0.6373588230941553 3.6010476774664517 20.905380840317463 -6.8762900353887915 1.1003235998669874 0.7846078823559546 3.796660001375563 0.9705657109340603 0.22645620101660952 0.1309650514770852 0.29260116506836653 0.1590370674183841 0.3812056708192214 1.3295661956815273e-07 6.8762900353887915 3.012052119019608 up DMEEGK(ub)AAFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DMEEGKAAFSK 11 1 A0A0D9SF98;A0A087WWJ5;A0A0D9SF30;A0A087WTF6;A0A087WX77;A0A087WWD4;A0A087WV75;P13591-1;P13591 A0A0D9SF98 NCAM1 Neural cell adhesion molecule 1 1 12525800.0 1509700.0 1861400.0 9154700.0 True False 1461775.3998679994 2604666.727072765 6756809.434886926 1.0 1.7818515261017327 4.62233078727216 20.479290229185846 -6.9470875303433965 0.5899528255629966 0.9671638195613017 5.579935869859362 0.9989524541334118 0.05037353438692916 0.08467675952790633 0.040968067363644736 0.05222661398782484 0.23795804767155224 1.1295682316982714e-07 6.9470875303433965 4.6127720502980605 DMEEGK(ub)AAFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DMEEGKAAFSK 11 1 A0A0D9SF98;A0A087WWJ5;A0A0D9SF30;A0A087WTF6;A0A087WX77;A0A087WWD4;A0A087WV75;P13591-1;P13591 A0A0D9SF98 NCAM1 Neural cell adhesion molecule 1 1 16857400.0 1690500.0 11289000.0 3877900.0 True False 2564612.0921045006 9274389.74864042 3111431.365256054 1.0 3.616293386899665 1.2132171468874413 21.29030919822926 -6.625989660106633 2.094928131432463 2.728690479134482 1.2227340669643803 0.10319395533375453 1.1234002490114297 0.569597942815419 4.758298764302598 0.43938512171847677 1.2448901694809305 2.3659760271183606e-07 6.625989660106633 -1.505956412170102 DMEEGK(ub)AAFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DMEEGKAAFSK 11 1 A0A0D9SF98;A0A087WWJ5;A0A0D9SF30;A0A087WTF6;A0A087WX77;A0A087WWD4;A0A087WV75;P13591-1;P13591 A0A0D9SF98 NCAM1 Neural cell adhesion molecule 1 1 8312240.0 1498100.0 862240.0 5951900.0 True False 2051988.0546302435 824143.3857536165 4546183.803228264 1.0 0.4016316683198833 2.2155020800291454 20.968590901840354 -6.817818901374181 1.3813562256926741 0.6767570814045828 2.2532568303882963 0.8792782432979559 0.26220715894231683 0.19633067747935434 0.7367161283805153 0.1491892175475919 0.34406128181395507 1.5211817226622876e-07 6.817818901374181 1.5764997489837134 up DMEEGK(ub)AAFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DMEEGKAAFSK 11 1 A0A0D9SF98;A0A087WWJ5;A0A0D9SF30;A0A087WTF6;A0A087WX77;A0A087WWD4;A0A087WV75;P13591-1;P13591 A0A0D9SF98 NCAM1 Neural cell adhesion molecule 1 1 11673900.0 1509700.0 3209000.0 6955200.0 True False 1255382.4410499725 3191712.4800633695 8409500.162788665 1.0 2.542422432955089 6.698755604511367 20.259695504620122 -6.953835657680038 0.5150184344453934 0.9265544514403333 8.498534957003933 0.9994689188028696 0.0554629566525254 0.08198116633434907 0.029864035255434535 0.06334270235978476 0.34316044539100515 1.1121524997114269e-07 6.953835657680038 7.5719805055636 DMEEGK(ub)AAFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DMEEGKAAFSK 11 1 A0A0D9SF98;A0A087WWJ5;A0A0D9SF30;A0A087WTF6;A0A087WX77;A0A087WWD4;A0A087WV75;P13591-1;P13591 A0A0D9SF98 NCAM1 Neural cell adhesion molecule 1 1 11173700.0 1690500.0 6639600.0 2843600.0 True False 2188385.574736838 6270100.423322522 2326093.9777999274 1.0 2.8651717026952737 1.0629269378544726 21.06143552032171 -6.638173338020058 2.051137364499711 2.221402363156586 1.070402551627759 0.14762962668287294 0.798417151096334 0.5379758218587143 4.323510174847141 0.31724465611299346 0.8840755185682491 2.3005234364848072e-07 6.638173338020058 -1.150999811528827 DMGYPLAVK(ub)LGTITPDGADVYSFQEEEPVLDPHLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DMGYPLAVKLGTITPDGADVYSFQEEEPVLDPHLAK 36 1 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 208394600.0 46911600.0 104088000.0 57395000.0 True False 71168326.8973496 85512683.15674415 46050853.09287783 1.0 1.2015553390777935 0.6470694914508778 26.084731984129384 -6.808330215877299 1.4213686209984908 1.1100636554823222 0.6377184463422256 0.8554786658308318 0.08711832718149949 0.2090770755648076 0.8327883092632372 0.048196870115528784 0.1115848784144375 1.5547830025565825e-07 6.808330215877299 -0.4723452091400966 DMGYPLAVK(ub)LGTITPDGADVYSFQEEEPVLDPHLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DMGYPLAVKLGTITPDGADVYSFQEEEPVLDPHLAK 36 1 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 205195600.0 61399600.0 62886000.0 80910000.0 True False 79482992.56705835 59386338.81876323 66185210.20670696 1.0 0.747157812014439 0.8326965061219569 26.24414285587786 -10.6470051496625 9.34118932843678 1.000105920050637 0.789927159068198 0.8894025622526095 0.0349210256379055 7.707014021412837e-05 2.9123875997182232e-06 0.03382901074831015 0.011270712560674193 2.2542124825880558e-11 10.6470051496625 -0.21017876098243904 DMILQFISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DMILQFISR 9 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 0 3891150.0 905550.0 1559400.0 1426200.0 False True 1187184.8193586743 1326743.5984935912 1278630.5050764238 1.0 1.1175543831585613 1.077027337468103 20.179113118639478 -10.170084804010736 4.33701079025011 0.9999755251472956 1.0972908603178981 0.8848469888009134 0.01654509713607707 3.916422014285461e-06 7.4948189688538e-07 0.016023750477241833 0.005339907136971634 6.759509706052695e-11 10.170084804010736 0.09731533517060253 DMILQFISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DMILQFISR 9 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 0 4297450.0 1953700.0 781350.0 1562400.0 False True 1891680.8629013144 1093347.1296864206 1153160.5690047021 1.0 0.5779765240155408 0.6095957260127236 20.851237287840302 -10.035974463180422 5.172701899780845 1.0000041892657145 0.5937861250127335 0.9954763955730167 0.012908485166058928 6.236405369315735e-07 1.162267413873136e-07 0.012498715865262735 0.004166195672041198 9.205036964236509e-11 10.035974463180422 -0.406218064252981 DMILQFISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DMILQFISR 9 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 0 4551150.0 905550.0 1858100.0 1787500.0 False True 1240356.3065685995 1776002.9980849817 1365329.3147180765 1.0 1.4318490490835083 1.1007557324356338 20.24232318016237 -10.004557893845146 5.002422940085478 0.9999972090511984 1.2663023907625128 0.46310381339018825 0.13516828051570653 4.20730079614258e-06 8.374203728868552e-07 0.1308774976586055 0.04362537494627568 9.895599412887835e-11 10.004557893845146 0.26630518171131445 DMK(ub)SCQFVAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DMKSCQFVAVR 11 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 17965400.0 3101600.0 3977600.0 10886200.0 True False 4066227.635937124 3384157.5845633675 9759800.451804064 1.0 0.8322597472542722 2.4002100535512123 21.955259551856777 -6.880428643519928 1.0773751095801019 0.8954295632122975 2.512260826683818 0.9740308510175939 0.11327931122280142 0.12725246633352438 0.26998069513305395 0.08096142773101998 0.19600540360482688 1.3169562766141596e-07 6.880428643519928 1.6168312634715203 up DMK(ub)SCQFVAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DMKSCQFVAVR 11 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 14243000.0 2585900.0 6021500.0 5635600.0 True False 2503812.019950099 8425916.351707676 4159467.2956239725 1.0 3.3652352031905357 1.6612538251601137 21.25569482166421 -6.561374627034327 2.3410754889390164 2.628244257381267 1.6640712894241938 0.0 1.0323424444856675 0.7569700516559003 7.776779975853285 0.3747993445006083 1.1606341797352837 2.7455248124665703e-07 6.561374627034327 -0.9641729679570732 DMK(ub)SCQFVAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DMKSCQFVAVR 11 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 23959800.0 3044200.0 5837100.0 15078500.0 True False 4618273.960830841 4795423.899529542 12098227.865858668 1.0 1.0383584733606472 2.6196427428229403 22.13892232715009 -6.9121187583767645 0.881186865232401 0.9542600193464663 2.83353334729737 0.9916967777257893 0.06876324762725679 0.1030334285810418 0.13129235265230982 0.05689394309398053 0.15945612778831994 1.224281372194069e-07 6.9121187583767645 1.8792733279509037 up DMK(ub)SCQFVAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DMKSCQFVAVR 11 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 17342700.0 3101600.0 5376200.0 8864900.0 True False 4248345.33758839 5138661.707284044 6771193.198346452 1.0 1.2095677961530897 1.5938424634260495 22.01846961337967 -6.961706880805052 0.41067002091412624 0.9812081005803851 1.8364785645074115 0.9998283594988255 0.003221669535990829 0.07909692942879598 0.018919243078639097 0.004949177843390828 0.03207713489824631 1.0921772329860137e-07 6.961706880805052 0.8552704639270264 DMK(ub)SCQFVAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DMKSCQFVAVR 11 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 17776500.0 2585900.0 8287000.0 6903600.0 True False 2150290.424793752 8242356.286159296 8347110.841360093 1.0 3.833136301553253 3.8818527698000227 21.036100097098487 -10.419594693086937 0.7892504648701608 1.717013678406437e-18 3.8716452024286325 0.9999623361024852 0.008267781809555622 1.8131415835111455 0.4165284232343935 3.852561600816046 0.007075201333942133 3.805443750815389e-11 10.419594693086937 3.8716452024286325 DMK(ub)SCQFVAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DMKSCQFVAVR 11 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 15317300.0 3044200.0 6899300.0 5373800.0 True False 3940776.910153148 6515347.890027882 4395823.539844292 1.0 1.6533155868939253 1.1154712992046687 21.91004864924254 -10.394307767899937 3.7354590985318277 0.997926060912293 1.3843934427779325 0.4051328933233188 0.2195740116778172 78648111.24306288 4160.426960490327 1420536.9728835814 0.07516580871440909 4.033594462372686e-11 10.394307767899937 0.38646738186563956 DMLEAGILDTYLGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 DMLEAGILDTYLGK 14 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 13667330.0 1191200.0 5717270.0 6758860.0 False True 1561674.7355972084 4864275.601743914 6059518.002763171 1.0 3.1147815168334274 3.8801408927486545 20.574662570687696 -9.422747371773598 0.3125143316439219 5.466629873209822e-22 4.154455832101061 0.9986088328538508 0.04543206702177213 0.8033595479506297 0.12362056024581945 1.1169333189118817 0.2547747875534764 3.777918878016917e-10 9.422747371773598 4.154455832101061 DMLEAGILDTYLGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 DMLEAGILDTYLGK 14 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 20853900.0 5619700.0 2522600.0 12711600.0 False True 5441305.699568253 3529887.3351852144 9382050.620174186 1.0 0.6487206435516567 1.7242278118868817 22.375521452465925 -6.818733300754361 1.3773174622861408 0.8104153315535594 1.747080629381232 0.8814494949931253 0.1541782760750054 0.1951340725933079 0.7277003136156989 0.08797314290315734 0.2028384479687806 1.5179822707224267e-07 6.818733300754361 0.9366652978276726 DMLEAGILDTYLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DMLEAGILDTYLGK 14 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 15179410.0 1191200.0 6645370.0 7342840.0 False True 1631618.830969593 6351755.580100102 5608612.422536774 1.0 3.8929163230639827 3.4374526182710476 20.637872632210588 -9.747324657296758 16.43124153041218 1.0000000003653735 3.665184470667517 0.9785659439593639 0.18594227885005332 0.0 0.0 0.180037837335528 0.06001261244517598 1.789267784945457e-10 9.747324657296758 2.6651844703021434 DMLEAGILDTYLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DMLEAGILDTYLGK 14 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 8566400.0 5619700.0 1155800.0 1790900.0 False True 4673029.544921856 1149573.4759916621 2165368.9098139824 1.0 0.24600175644960223 0.4633758226859643 22.1559267279002 -10.21327934859764 5.091264155012548 1.000063733173395 0.3546887895693184 0.9215725932113052 0.08874259093359352 6.420499970645532e-05 9.921154011926163e-06 0.08593308112157934 0.028641548065221643 6.119566399562846e-11 10.21327934859764 -0.6453749436040767 DMLLANK(ub)VPAAAR ddPTM_RPMI8226_Bortezomib_1h_R1 2 DMLLANKVPAAAR 13 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 56944400.0 15695300.0 24101500.0 17147600.0 True False 20576690.29350143 20505650.146911193 15373330.843393963 1.0 0.99654754260394 0.7471235958801984 24.294507611402285 -6.909915766488911 0.8963094251764347 1.0077432457341469 0.7149478753655164 0.9908897135248371 0.011301184443078769 0.10447371054942767 0.13907002184210396 0.009248579536487217 0.025515349928914476 1.2305074105208567e-07 6.909915766488911 -0.29279537036863046 DMLLANK(ub)VPAAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DMLLANKVPAAAR 13 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 67014100.0 18441500.0 28260400.0 20312200.0 True False 17856084.676866718 39544925.09603912 14991825.467061765 1.0 2.2146470411439734 0.8395919787770879 24.08991243803507 -6.673561563659184 1.925058863294348 1.7729366903079269 0.8450948274822988 0.29477715297133267 0.51553935691007 0.4529947176613639 3.239832671787902 0.2153548482545368 0.5726502985213636 2.1205007790000455e-07 6.673561563659184 -0.9278418628256281 DMLLANK(ub)VPAAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DMLLANKVPAAAR 13 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 147780000.0 46331000.0 40779000.0 60670000.0 True False 70287514.249804 33501668.84221872 48678547.90739431 1.0 0.47663755362229415 0.6925632301405517 26.066765098463755 -10.247851697070434 5.57120878068657 1.0000267972885573 0.5846003918814094 0.8314999914366307 0.08815128830588256 2.934260102761225e-05 3.9614388888182604e-06 0.08535761430141192 0.028450705962943596 5.6512992249737726e-11 10.247851697070434 -0.4154264054071478 DMLLANK(ub)VPAAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DMLLANKVPAAAR 13 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 44271800.0 12154000.0 15005700.0 17112100.0 True False 16647662.249500051 14342698.556785868 13070574.414762076 1.0 0.8615443022467972 0.7851297208504215 23.988816265060912 -13.999999978944835 0.07122487615917163 1.7934890267072385 0.5146642083208025 0.9999201963535588 0.0007944247617624323 12.347632339163502 0.07243940242332095 1.61601918909959 0.2486465344435772 1.0000000484813096e-14 13.999999978944835 -1.2788248183864361 DMLLANK(ub)VPAAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DMLLANKVPAAAR 13 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 53911900.0 18441500.0 25460200.0 10010200.0 True False 15334924.346971614 25323040.84914597 12103286.538064623 1.0 1.6513313190323524 0.7892628789169616 23.870317713469348 -6.7046351073112325 1.8145326843630665 1.402603798193952 0.791608061209824 0.43952470441792846 0.274709250472324 0.38595037645436553 2.4736464468313595 0.12064026452218664 0.30846998857713664 1.9740806551179132e-07 6.7046351073112325 -0.6109957369841281 DMLLANK(ub)VPAAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DMLLANKVPAAAR 13 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 177793400.0 63589200.0 52216000.0 61988200.0 True False 82317472.93052702 49310133.69844704 50706983.65264366 1.0 0.5990239003092699 0.6159929580860497 26.294695357734025 -10.169236012474439 8.048239722439787 1.0000000808430412 0.6075084292061456 0.9986000647689163 0.006927588828152881 1.0054844072196684e-08 1.0307781997530894e-09 0.006707610439503416 0.002235869680067384 6.772733509636519e-11 10.169236012474439 -0.3924916516368956 DMLLANPHELSLLK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 2 DMLLANPHELSLLKER 16 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2;H0YII4;H0YI90 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 1668119400.0 640650000.0 598073400.0 429396000.0 True False 839898354.0634258 508843179.9918543 384966220.977279 1.0 0.605839001267323 0.4583485836289755 29.645639500130983 -13.999999999999998 0.13645013674165085 2.8777847040655637 0.26777267976872904 0.9996174580865687 0.004471970168514917 11.932045170993883 0.11546093999565782 5.978851313945242 0.16999859076171805 1.0000000000000041e-14 13.999999999999998 -2.6100120242968345 DMLLANPHELSLLK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 2 DMLLANPHELSLLKER 16 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2;H0YII4;H0YI90 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 2734661100.0 993016000.0 954723600.0 786921500.0 True False 961493250.6294777 1335949712.2978015 580803152.0110295 1.0 1.3894530319616614 0.604063680770286 29.840701489448723 -6.771860276107844 1.5672101472279076 1.2228456797227993 0.5993183702688315 0.7376821880821882 0.16422081607551556 0.2634246390144028 1.2771286968397613 0.08257982879799813 0.19625057177945968 1.6909848781942774e-07 6.771860276107844 -0.6235273094539678 DMLLANPHELSLLK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 2 DMLLANPHELSLLKER 16 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2;H0YII4;H0YI90 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 2780362000.0 1035716800.0 970670200.0 773975000.0 True False 1571258106.6405103 797446518.9291127 620998502.0047059 1.0 0.5075210212497323 0.3952237378316259 30.549273041992357 -13.999999999999998 0.20770735332172183 3.821685685143446 0.32759175999045953 0.9994888527347289 0.005938306147732797 12.693980711573806 0.14446873934408716 14.601534138996582 0.06760404850254546 1.0000000000000041e-14 13.999999999999998 -3.4940939251529866 DMLLANPHELSLLK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DMLLANPHELSLLKER 16 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2;H0YII4;H0YI90 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 1915595800.0 640650000.0 643336800.0 631609000.0 True False 877515617.915271 614912052.9456962 482435962.59567606 1.0 0.7007420043492256 0.5497747877602538 29.708849561653874 -13.99999999999852 0.08839634461715021 2.5433634660961726 0.1614452307596076 0.9998498687694923 0.0022924616230271793 12.178301911659622 0.08598945484576667 3.5518398490552574 0.34942722497003564 1.0000000000034071e-14 13.99999999999852 -2.381918235336565 DMLLANPHELSLLK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DMLLANPHELSLLKER 16 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2;H0YII4;H0YI90 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 2392303300.0 993016000.0 831474500.0 567812800.0 True False 825736802.0677489 826995181.8337333 686539831.2102439 1.0 1.0015239477795264 0.8314269504411839 29.621106764883 -6.904877467089604 0.9299049381362824 1.006157116844616 0.8116922485386633 0.9888408911046848 0.008432733638218318 0.1079039757288345 0.1578589299202644 0.00673370002778326 0.017990343729879576 1.244865791715649e-07 6.904877467089604 -0.19446486830595267 DMLLANPHELSLLK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DMLLANPHELSLLKER 16 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2;H0YII4;H0YI90 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 3017215500.0 1035716800.0 1495046700.0 486452000.0 True False 1340755814.6303477 1411846036.893328 397922727.4190211 1.0 1.0530224978234237 0.2967898576883891 30.320399364084807 -6.890075146314912 1.021901522052901 1.040559927132848 0.23164209613079698 0.9809476351180665 0.047575505656311114 0.11908365686343136 0.22147379029620187 0.03546856868933555 0.08845076599900546 1.2880266641463208e-07 6.890075146314912 -0.8089178310020511 down DMQGLSLDAASQPSK(ub)GGLLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DMQGLSLDAASQPSKGGLLER 21 1 E9PLL0;M0QZK6;E9PLZ8;E9PQA6;Q96EY5-3;Q96EY5 E9PLL0 MVB12A Multivesicular body subunit 12A 1 9203700.0 0.0 3446500.0 5757200.0 True False 0.0 4822705.423260068 4249216.607702164 0.0 DMQGLSLDAASQPSK(ub)GGLLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DMQGLSLDAASQPSKGGLLER 21 1 E9PLL0;M0QZK6;E9PLZ8;E9PQA6;Q96EY5-3;Q96EY5 E9PLL0 MVB12A Multivesicular body subunit 12A 1 9405400.0 0.0 5924400.0 3481000.0 True False 0.0 5892484.081298673 4208861.0056745075 0.0 DMQGLSLDAASQPSK(ub)GGLLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DMQGLSLDAASQPSKGGLLER 21 1 E9PLL0;M0QZK6;E9PLZ8;E9PQA6;Q96EY5-3;Q96EY5 E9PLL0 MVB12A Multivesicular body subunit 12A 1 23218500.0 8065900.0 6486100.0 8666500.0 True False 10441466.552658895 6125142.833259873 7089285.925799366 1.0 0.5866171004206415 0.6789550002431504 23.315821023595873 -9.675383730917309 12.759124628853932 1.0000000073507063 0.6327860504301399 0.9547247259855438 0.037696789747562916 0.0 0.0 0.03649975972444833 0.012166586574816106 2.1116224425542156e-10 9.675383730917309 -0.36721395692056635 DMTGK(ub)EDNYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DMTGKEDNYR 10 1 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 1 617460.0 362660.0 254800.0 0.0 True False 496745.2025179924 243542.09348907683 0.0 1.0 0.49027568309581326 0.0 18.92214650867185 -7.959155153960226 0.5870148827765861 1.0121368382623372 8.803542855634488e-19 0.9892413463481788 0.04234778612588376 0.11190270522435733 0.16293411332437935 0.04540522887764657 0.0766806351455351 1.0986132840114279e-08 7.959155153960226 -1.0121368382623372 DMTMFVTASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DMTMFVTASK 10 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 28444900.0 6725700.0 7767200.0 13952000.0 False True 8817457.83177145 6608364.03630846 12508380.87703426 1.0 0.7494636393379636 1.4185926505895514 23.071931340509902 -6.805281053500869 1.4341243080732495 0.8626780832061168 1.4290934696635684 0.847183923993984 0.10790393417094678 0.21330782933954917 0.8654713408028054 0.05917494511896416 0.13720900575369893 1.565737475786535e-07 6.805281053500869 0.5664153864574516 DMTMFVTASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DMTMFVTASK 10 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 19324800.0 4614900.0 3171900.0 11538000.0 False True 4468402.525568546 4438456.211239979 8515851.6674195 1.0 0.9932982057553651 1.905793316222327 22.0913277228008 -6.905244678187816 0.9275090788166591 0.9673248161160357 2.012468532770391 0.9889998271616611 0.04495056164262856 0.10764763286806371 0.1564458408734687 0.035957291410340146 0.09627402634732818 1.243813659236519e-07 6.905244678187816 1.0451437166543553 DMTMFVTASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DMTMFVTASK 10 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 18253300.0 6725700.0 5352000.0 6175600.0 False True 9212373.04520836 5115530.943302749 4717050.470474383 1.0 0.5552891657989789 0.5120342443066683 23.135141402032794 -13.999999999999998 0.3295062781904184 5.826600341150213 0.5043294777123027 0.9997138158791379 0.0037309009437157246 18.781788693429924 0.18353357273695103 62.807461272998644 0.01388678801394689 1.0000000000000041e-14 13.999999999999998 -5.32227086343791 DMTMFVTASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DMTMFVTASK 10 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 11161300.0 4614900.0 2834200.0 3712200.0 False True 3837493.8247343977 2818931.6020553503 4488403.856726483 1.0 0.7345761923800503 1.1696185223274298 21.871732998235075 -6.741537800883116 1.680749863422606 0.8423638679729318 1.1699784363094934 0.6120267514654805 0.11151647885627547 0.3150073114963111 1.7477871501375708 0.05247327871451796 0.1285637338886848 1.8132688425353406e-07 6.741537800883116 0.32761456833656155 DMTMFVTASK(ub)DNTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DMTMFVTASKDNTAK 15 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 6661600.0 1023600.0 2229700.0 3408300.0 True False 1341949.5125565014 1897037.451302528 3055641.810722177 1.0 1.4136429377946922 2.277016968321692 20.355898964145045 -6.95920175879547 0.4465498974813017 0.9711549641768441 2.7535348628043845 0.999739414040344 0.008588021804518666 0.07998763424859569 0.022195086451680474 0.011482351584593046 0.0714534933057716 1.0984953963888211e-07 6.95920175879547 1.7823798986275405 up DMTMFVTASK(ub)DNTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DMTMFVTASKDNTAK 15 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 8793100.0 1975200.0 1895900.0 4922000.0 True False 1912498.3571698181 2652942.756987887 3632780.543165093 1.0 1.3871608030627562 1.8994947261241093 20.86702707785941 -6.967256108587681 0.3169508696837463 0.9272775490991895 2.3758292608882168 0.9999523844950909 0.0025421037877123177 0.07720347635285944 0.01220268460316089 0.007864250440495501 0.0451895159526789 1.0783106421690965e-07 6.967256108587681 1.4485517117890274 DMTMFVTASK(ub)DNTAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DMTMFVTASKDNTAK 15 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 85218000.0 3462000.0 11604000.0 70152000.0 True False 5252107.106102217 9533175.537534185 56286426.45128613 1.0 1.8151144569115818 10.71692281101601 22.324464906702524 -6.924799599400093 0.7883168192070661 0.8354278278077274 12.323808717643798 0.9954135259506182 0.2980562905637538 0.09542949009709514 0.09157997953267158 0.2635657144596107 0.8296799950390341 1.1890507757833077e-07 6.924799599400093 11.48838088983607 up DMTMFVTASK(ub)DNTAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DMTMFVTASKDNTAK 15 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 15252200.0 1975200.0 5191100.0 8085900.0 True False 1642466.316196534 5163134.513947325 9776624.305022545 1.0 3.1435253575876163 5.952404751692146 20.647432353293688 -6.9674053697662 0.3140398804107855 0.5874031644480595 8.59833863102469 0.9999544904987256 0.01368025151686823 0.077153925415537 0.012029313347993344 0.043654507689260914 0.24841814653110963 1.0779401049668715e-07 6.9674053697662 8.010935466576631 DMTMFVTASK(ub)DNTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DMTMFVTASKDNTAK 15 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 75363500.0 3462000.0 7077500.0 64824000.0 True False 4481627.24622239 6683630.903377496 53026697.15040883 1.0 1.49134020662053 11.832018647937662 22.095591228794973 -6.916808018249091 0.8480675167828772 0.7445532267436274 13.38295688051297 0.9932472706502823 0.4104215376346557 0.10008637232065094 0.11561657609213384 0.34776853738495533 1.011955096778511 1.2111334019826476e-07 6.916808018249091 12.638403653769341 up DMVK(ub)FGGSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DMVKFGGSGR 10 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 15300400.0 6657400.0 4798800.0 3844200.0 True False 8727915.870353311 4082837.7455758974 3446439.0601702305 1.0 0.4677906852246757 0.3948753759046851 23.057205764706016 -13.999999999999998 0.2800806985406594 5.339380582123011 0.37294215417994686 0.9996053561641021 0.005358155700310397 15.402647896078332 0.1676495268604631 38.28675559450472 0.02883237000442531 1.0000000000000041e-14 13.999999999999998 -4.966438427943064 DMVK(ub)FGGSGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DMVKFGGSGR 10 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 27968700.0 7779000.0 11190000.0 8999700.0 True False 11801311.721077148 9193057.072130939 7220905.350291354 1.0 0.7789860389597315 0.6118731138501167 23.492443888910334 -6.974217621041233 0.12047452669213154 1.298523693143153 0.08804025128571819 0.9999994369678142 0.0001191370555011364 0.0749564435582563 0.003588940540900158 0.011707223690594577 0.024022876203350512 1.0611636844163902e-07 6.974217621041233 -1.2104834418574348 DMVK(ub)FGGSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DMVKFGGSGR 10 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 12878600.0 6657400.0 4013700.0 2207500.0 True False 9118820.689470263 3836361.4624690264 1686133.9648895992 1.0 0.42070807104464414 0.1849070205796043 23.120415826228907 -10.299150224540965 0.20666310406366997 1.715725875498527 4.982831008862262e-13 0.9993566404198398 0.008686534589803728 1.919231736759983 0.10109134445418001 0.8664916196716439 0.1355193439225654 5.021688568643515e-11 10.299150224540965 -1.7157258754980287 DMVK(ub)FGGSGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DMVKFGGSGR 10 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 21698200.0 7779000.0 10871000.0 3048200.0 True False 10070068.847014418 10266019.293622985 2493458.877173208 1.0 1.0194586997949535 0.2476109066436493 23.263570211002783 -6.901116490524889 0.9541735646981933 1.0311149327643232 0.16472748284201755 0.9871138888014993 0.04079277885691799 0.11058841663991237 0.17281724270842191 0.031995341464651016 0.08372338645823102 1.255693104778793e-07 6.901116490524889 -0.8663874499223057 down DMVVDIQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DMVVDIQR 8 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 22639800.0 4223600.0 7787200.0 10629000.0 False True 5537180.501400579 6625380.1142678615 9529213.040567461 1.0 1.1965259417842768 1.7209504075507625 22.40072012103374 -6.954049423625572 0.512463375864726 0.9905405957216188 1.9500398998114046 0.9994819457824696 0.006926220687262993 0.08189930073325279 0.029539631097710357 0.00794414429623278 0.04328952503489957 1.1116052170712167e-07 6.954049423625572 0.9594993040897858 DMVVDIQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DMVVDIQR 8 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 17528900.0 2900100.0 2397800.0 12231000.0 False True 2808037.9129344793 3355254.044361814 9027334.177865138 1.0 1.1948749085283816 3.2148191932463326 21.42113098375344 -6.925617048750905 0.781932528223809 0.9637867499336403 3.586723670432606 0.995604482290042 0.06638547725162648 0.09497820045821351 0.08930368929096076 0.05897180614347077 0.18736710072191312 1.1868147938918973e-07 6.925617048750905 2.6229369204989657 up DMVVDIQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DMVVDIQR 8 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 17370400.0 4223600.0 2069800.0 11077000.0 False True 5785179.058498298 1978349.3920866994 8460840.737976018 1.0 0.34196856693321337 1.4625028287667663 22.46393018255663 -6.747571516203593 1.6590219910267208 0.6119418810021267 1.464298567766885 0.6383848949445264 0.2764812251890795 0.30429642392972317 1.6471043844769497 0.13169742115045063 0.32052148596093905 1.7882510297288996e-07 6.747571516203593 0.8523566867647583 DNAGAATEEFIK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNAGAATEEFIKR 13 1 P09972;A8MVZ9 P09972 ALDOC Fructose-bisphosphate aldolase C;Fructose-bisphosphate aldolase 1 10534500.0 3510200.0 4832700.0 2191600.0 True False 4601906.192825158 4111679.9977170615 1964834.2553116607 1.0 0.8934732316203209 0.42696095334907913 22.13380014468859 -6.942799515176708 0.6329862012816565 1.0050907285701185 0.29007208968802645 0.9985080410274058 0.009612209256188102 0.08651244758128765 0.04896622352864209 0.009568642683943054 0.03968318066398915 1.1407762864234626e-07 6.942799515176708 -0.715018638882092 down DNAGAATEEFIK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNAGAATEEFIKR 13 1 P09972;A8MVZ9 P09972 ALDOC Fructose-bisphosphate aldolase C;Fructose-bisphosphate aldolase 1 8810300.0 5146300.0 3664000.0 0.0 True False 4982933.523442202 5127054.307507581 0.0 1.0 1.028922879140844 0.0 22.24856389669902 -7.002679048443058 1.1177733174431121 1.0314954996176688 3.431884635170167e-20 0.9835407892358954 0.06137141399741908 0.09144513831671447 0.22341982687003978 0.04624178418899689 0.08468469894345038 9.938502505865228e-08 7.002679048443058 -1.0314954996176688 down DNAGAATEEFIK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DNAGAATEEFIKR 13 1 P09972;A8MVZ9 P09972 ALDOC Fructose-bisphosphate aldolase C;Fructose-bisphosphate aldolase 1 31141700.0 8456100.0 9547600.0 13138000.0 True False 12828521.923717763 7843756.184260723 10541268.541410025 1.0 0.611431015272223 0.821705618471993 23.612851619817317 -10.072086593870363 5.06998666669634 1.0000055968001427 0.7165683168710684 0.7078150174592308 0.08584424728788674 5.430856185469569e-06 9.939432924302396e-07 0.0831199763960687 0.027706111675623278 8.470585025142088e-11 10.072086593870363 -0.2834372799290743 DNAGAATEEFIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNAGAATEEFIKR 13 1 P09972;A8MVZ9 P09972 ALDOC Fructose-bisphosphate aldolase C;Fructose-bisphosphate aldolase 1 15385800.0 5146300.0 6468800.0 3770700.0 True False 4279376.469745963 6433951.290443732 4559135.936253049 1.0 1.5034786810485201 1.0653738853042984 22.028969172133298 -10.467295206536251 5.2971811629021435 0.9995713173297687 1.284426283176412 0.359787633919593 0.17885553390660827 0.000906832493559178 9.119406063266654e-05 0.1734323661225792 0.05772537534977603 3.4096106858186765e-11 10.467295206536251 0.28485496584664327 DNAGAATEEFIK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DNAGAATEEFIKR 13 1 P09972;A8MVZ9 P09972 ALDOC Fructose-bisphosphate aldolase C;Fructose-bisphosphate aldolase 1 29197100.0 8456100.0 10394000.0 10347000.0 True False 10946588.144650808 9815564.762939675 8463952.16918547 1.0 0.8966779998694093 0.7732045873418094 23.383977941909766 -6.968758958472325 0.2862820837164409 1.0252242726188994 0.6408631671897499 0.999971014555782 0.0004991030944434963 0.07670749181013581 0.010464624103075361 0.0022012812464058964 0.01124618221532618 1.0745856619213232e-07 6.968758958472325 -0.3843611054291495 DNALTLLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNALTLLIK 9 0 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 0 4324900.0 1423400.0 1371400.0 1530100.0 False True 1866091.184225208 1166792.4656753317 1371779.9297555985 1.0 0.6252601563839327 0.7351087349598916 20.831588052735402 -10.413866863858837 8.708020195573303 1.0000025167518423 0.6801844456719128 0.9187113223924169 0.04484549441352054 2.1911674542748768e-06 1.4756766420235168e-07 0.04342180412982428 0.014473821084666908 3.855965469829586e-11 10.413866863858837 -0.31981807107992943 DNALTLLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNALTLLIK 9 0 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 0 4220100.0 1423400.0 1354700.0 1442000.0 False True 1949669.4459386498 1294844.8746061702 1101429.2989222212 1.0 0.6641355934994301 0.5649313021838677 20.894798114258293 -13.999999999999998 0.17094290052239736 2.6979951238070727 0.47829442066173944 0.9995119101953989 0.004112989186589659 12.100845150143217 0.13094553563726347 6.81402784279306 0.08019100182196766 1.0000000000000041e-14 13.999999999999998 -2.2197007031453335 DNAMLEYLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNAMLEYLK 9 0 P15311;E7EQR4 P15311 EZR Ezrin 0 6595750.0 609950.0 3018900.0 2966900.0 False True 799650.3567642028 2568491.887580031 2659913.6485143993 1.0 3.2120186852332213 3.32634585355252 19.609009800904605 -10.390714405728287 0.5973222505067645 7.737447449821021e-20 3.313238083779099 0.9997777590731509 0.01596203019276273 1.7434255688991622 0.28959039866066816 2.81179117711909 0.019913316533124607 4.067106962778455e-11 10.390714405728287 3.313238083779099 DNAMLEYLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNAMLEYLK 9 0 P15311;E7EQR4 P15311 EZR Ezrin 0 8234800.0 2468900.0 928800.0 4837100.0 False True 2390526.1209075325 1299674.6836280122 3570118.4001104995 1.0 0.5436772567599502 1.4934446308225864 21.188896739200484 -6.776024383436248 1.5509969950987315 0.740286048057151 1.5000982386076585 0.7531897805177428 0.1926787135012476 0.2568039307241989 1.2198341314716599 0.09786702018966072 0.23173911668046157 1.6748488391043592e-07 6.776024383436248 0.7598121905505074 DNAMLEYLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNAMLEYLK 9 0 P15311;E7EQR4 P15311 EZR Ezrin 0 7808750.0 609950.0 3525100.0 3673700.0 False True 835464.998278966 3369349.4260531566 2806047.7222264656 1.0 4.032903153326495 3.3586658064752486 19.672219862427497 -9.574610627126141 8.268559324603757 1.0000000010978423 3.6957844799009005 0.9551869092623095 0.27525624421901707 0.0 0.0 0.2665157124499165 0.08883857081663882 2.663111640268262e-10 9.574610627126141 2.6957844788030583 DNDFINEGQK(ub)IYIDDNNKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNDFINEGQKIYIDDNNKK 19 2 P48426;P48426-2;H7BXS3;S4R320 P48426 PIP4K2A Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 1 7445600.0 1629200.0 1731100.0 4085300.0 True False 1577481.937778993 2422337.2575672446 3015237.373627052 1.0 1.535572103587925 1.9114243411701684 20.589192055720044 -7.5317645870506125 0.10134310039681801 1.891646613929951e-18 3.2468992712541964 0.9999968235029382 0.0006665219892186557 0.13685924531749163 0.009372951055876292 0.11989471463360885 0.16960018888424258 2.9392424611375053e-08 7.5317645870506125 3.2468992712541964 DNDFINEGQK(ub)IYIDDNNKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DNDFINEGQKIYIDDNNKK 19 2 P48426;P48426-2;H7BXS3;S4R320 P48426 PIP4K2A Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 1 30924400.0 3752400.0 10575000.0 16597000.0 True False 5692665.137186001 8687808.627147872 13316595.675276484 1.0 1.5261408176632063 2.3392550509055843 22.440672807094717 -6.964756846569356 0.3622054780699191 0.931675769450097 2.9616801438606672 0.9999080396923091 0.00528306428229699 0.0780436156356774 0.015151773608462458 0.010861816948333967 0.0693596480304039 1.0845339545289719e-07 6.964756846569356 2.03000437441057 DNDFINEGQK(ub)IYIDDNNKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNDFINEGQKIYIDDNNKK 19 2 P48426;P48426-2;H7BXS3;S4R320 P48426 PIP4K2A Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 1 6253400.0 1629200.0 3093800.0 1530400.0 True False 1354751.9857975864 3077133.085328781 1850399.5642298947 1.0 2.271362668287342 1.365858536195837 20.36959733115432 -10.21778389020009 5.12559416485351 0.9999198774798311 1.8186106022420008 0.5214656531899653 0.36967051393575484 0.0003384994492557361 5.165831400109014e-05 0.3579666378470931 0.11931064533788703 6.056421741140133e-11 10.21778389020009 0.8186907247621696 DNDFINEGQK(ub)IYIDDNNKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DNDFINEGQKIYIDDNNKK 19 2 P48426;P48426-2;H7BXS3;S4R320 P48426 PIP4K2A Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 1 29259500.0 3752400.0 8509100.0 16998000.0 True False 4857555.770862182 8035561.104899955 13904538.414208457 1.0 1.6542395978448436 2.86245574319788 22.211799129187167 -6.96157350886556 0.4126595064242674 0.9421809777508434 3.6195472691189674 0.9998241782807646 0.010229580086263745 0.07914375192207479 0.01908927742834489 0.01557135181872157 0.10079189427485945 1.0925126923832517e-07 6.96157350886556 2.677366291368124 DNEEK(ub)DSAFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DNEEKDSAFR 10 1 Q92973-2;Q92973;Q92973-3;S4R398;O14787-2;O14787 Q92973-2;O14787-2 TNPO1;TNPO2 Transportin-1;Transportin-2 1 7979340.0 815040.0 3648600.0 3515700.0 True False 1236475.2674054161 2997478.8233580883 2820820.3540139487 1.0 2.424212519549955 2.2813398928173276 20.237801951835355 -10.069434838903 4.477714139252385 0.9999092629291431 2.3527762061713715 0.9917036070833861 0.05832750592237165 13569566.508709757 13825608.943422822 15325.486678887579 0.02134568131105701 8.522463719552978e-11 10.069434838903 1.3528669432422284 DNEEK(ub)DSAFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DNEEKDSAFR 10 1 Q92973-2;Q92973;Q92973-3;S4R398;O14787-2;O14787 Q92973-2;O14787-2 TNPO1;TNPO2 Transportin-1;Transportin-2 1 6244740.0 815040.0 3164800.0 2264900.0 True False 1055085.3468402934 2988676.097917213 1852711.439836495 1.0 2.8326391858891053 1.7559825329627454 20.008928273927804 -10.655600169114548 6.219162600245499 0.9906640391899673 2.2943108594253845 0.6583427776754212 0.43954323797373135 0.05629899687071463 0.0031176780389727352 0.4211070687347117 0.14186197005086207 2.2100384567586345e-11 10.655600169114548 1.3036468202354172 DNFWEMGDTGPCGPCSEIHYDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNFWEMGDTGPCGPCSEIHYDR 22 0 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 5272400.0 1576500.0 2340100.0 1355800.0 False True 2066806.7668477155 1990966.2016383586 1215514.8217519382 1.0 0.9633054398573367 0.5881124647205583 20.978972081676293 -6.9258361446945464 0.7802166208553132 1.0066713973986836 0.5186654962467434 0.9956545806707884 0.012269024506855162 0.09485841313962694 0.08870093709649934 0.010912210118808139 0.03475812772289614 1.1862162121942156e-07 6.9258361446945464 -0.4880059011519402 DNGDIK(ub)FLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNGDIKFLTK 10 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 87328200.0 6363800.0 6142400.0 74822000.0 True False 8343003.427126857 5225977.8628876675 67080137.183303915 1.0 0.6263904729914964 8.040286423135846 22.99213540735823 -6.895036925009348 0.9921227126160694 0.6483969827544178 8.744576046400507 0.9839307988683256 0.43230396697254564 0.11515091102544256 0.1987424453441645 0.32961712061852955 0.8381185955445317 1.273394808597548e-07 6.895036925009348 8.096179063646089 up DNGDIK(ub)FLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNGDIKFLTK 10 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 128404100.0 4519100.0 10235000.0 113650000.0 True False 4375643.644130275 14321888.874819892 83881655.57308258 1.0 3.2730930668981806 19.17012956153456 22.06106381801672 -6.932686112167166 0.7244069926915244 0.7807010272087124 22.668740137300723 0.9970402817390887 0.4397501642663354 0.091266960545089 0.07102271940808896 0.40723646984852513 1.4177617864812948 1.1676532375591553e-07 6.932686112167166 21.88803911009201 DNGDIK(ub)FLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DNGDIKFLTK 10 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 291959000.0 17219000.0 113880000.0 160860000.0 True False 26122481.87751994 93557224.25149888 129065950.49255742 1.0 3.5814829804518244 4.940799694979477 24.638788636987535 -8.726322741677002 0.2894758550846196 3.427413995006008e-21 5.671028853472214 0.9987969853035015 0.05668873724944731 0.2872930927877421 0.08952552122742714 0.7695849462696157 0.4685700728216381 1.8779207397810747e-09 8.726322741677002 5.671028853472214 DNGDIK(ub)FLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNGDIKFLTK 10 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 99439800.0 6363800.0 10197000.0 82879000.0 True False 8716668.835228587 9746462.823030276 63304687.14658439 1.0 1.1181407722683874 7.262486202382413 23.05534546888112 -6.911063030732811 0.8884712271910964 0.816095626181467 8.074844966654739 0.9913164326560412 0.27254158952477003 0.10371907622342522 0.13498775717555828 0.22431296933030936 0.6238566845593466 1.2272611013789975e-07 6.911063030732811 7.258749340473272 up DNGDIK(ub)FLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNGDIKFLTK 10 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 88103100.0 4519100.0 14534000.0 69050000.0 True False 3757831.8800748033 14455702.457226884 83488035.74887243 1.0 3.846819900026802 22.217075806810847 21.841469093450996 -6.934314967593572 0.7104801392246204 0.7603272337788919 26.439261844337473 0.997320430900817 0.4867382246292836 0.09045837356077445 0.06715225584186243 0.4554317072037484 1.624564433936345 1.1632820650899667e-07 6.934314967593572 25.67893461055858 DNGDIK(ub)FLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DNGDIKFLTK 10 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 282059000.0 17219000.0 115580000.0 149260000.0 True False 22290334.93723376 109147871.39701438 122096211.53693104 1.0 4.896645640559391 5.4775404623006185 24.409914959079984 -9.724219780429033 0.5055366202390859 2.1785057030563477e-19 5.463803444827055 0.9988514275949701 0.06737484155321505 1.0154577208040276 0.22470478181813347 1.8817827600986743 0.11615250463203383 1.8870361479830106e-10 9.724219780429033 5.463803444827055 DNGK(ub)HALIIYDDLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNGKHALIIYDDLSK 15 1 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 1 10073500.0 3481000.0 1988600.0 4603900.0 True False 3370497.560403066 2782658.3504120004 3398000.4759605387 1.0 0.8255927501930106 1.0081598977790636 21.684530150327674 -13.778766015928156 17.41630240127992 9.457700664754215 0.9251886600024781 0.0 0.08641047031692993 0.0 0.0 0.0 0.024988724667096604 1.6643090857330265e-14 13.778766015928156 -8.532512004751737 DNHLLGTFDLTGIPPAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNHLLGTFDLTGIPPAPR 18 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 41566300.0 8994300.0 18408000.0 14164000.0 False True 11791614.4009251 15661598.153822 12698445.150681851 1.0 1.328197956727052 1.076904715412472 23.4912579167754 -10.623312370389192 6.527836320394857 0.9992959882847201 1.2025513360697582 0.4641684541248904 0.1025900361718003 0.0010546650602536334 6.0859213516440044e-05 0.09966649621754817 0.03311079179834993 2.380606579762449e-11 10.623312370389192 0.20325534778503807 DNHLLGTFDLTGIPPAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNHLLGTFDLTGIPPAPR 18 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 62711000.0 25495000.0 11158000.0 26058000.0 False True 24685675.180257447 15613447.588201327 19232628.076756578 1.0 0.6324901982299556 0.7791007511975211 24.557170769119914 -10.07326561296156 5.029801255568272 1.0000064174067835 0.7057954757358292 0.8429936134926004 0.05985350761745225 4.307357659389657e-06 7.935849452039653e-07 0.05795417350179275 0.01931763651723242 8.447620336790272e-11 10.07326561296156 -0.2942109416709543 DNHLLGTFDLTGIPPAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNHLLGTFDLTGIPPAPR 18 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 43034300.0 8994300.0 14487000.0 19553000.0 False True 12319735.771818181 13846916.437897382 14934984.10667557 1.0 1.1239621282765397 1.2122812033712491 23.55446797829829 -6.97478575811631 0.08638943074908655 0.7241667599634827 1.614299890596889 0.99999985742649 3.236564699208948e-05 0.07477849004072439 0.0025148006586854467 0.009640897737138011 0.01614747970747787 1.0597763947185713e-07 6.97478575811631 0.8901331306334064 DNHLLGTFDLTGIPPAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNHLLGTFDLTGIPPAPR 18 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 44998600.0 25495000.0 9591900.0 9911700.0 False True 21200222.120003358 9540226.53085693 11984190.643477175 1.0 0.4500059705438322 0.565286088779681 24.33757604455419 -10.45423964234788 8.889465618959477 1.000006930419266 0.5076460296619413 0.9605073828641719 0.04706291119425728 6.464295661242224e-06 3.9683196550083303e-07 0.04556910790225698 0.015189489273283086 3.513665040794847e-11 10.45423964234788 -0.49236090075732475 DNHLLGTFDLTGIPPAPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DNHLLGTFDLTGIPPAPR 18 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 72880300.0 8684800.0 39674000.0 24521500.0 False True 11242644.803001778 37466107.02375111 20058838.6118374 1.0 3.332499396738718 1.784174361399526 23.422478129959824 -10.243315514711675 6.215027186890183 0.9999691080547948 2.558336879069124 0.5745825665343548 0.6321010487596327 0.00027057527575964527 3.2943015863978425e-05 0.6120412171324924 0.20400973624719065 5.7106360852134425e-11 10.243315514711675 1.558367771014329 DNHVVAAGGVEK(ub)AVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNHVVAAGGVEKAVR 15 1 Q15274 Q15274 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] 1 19083500.0 1657300.0 1412200.0 16014000.0 True False 1604689.9186601536 1976098.8245257128 11819452.990297804 1.0 1.2314521338650082 7.365568171679257 20.6138631152509 -6.914873114519336 0.8618756824723821 0.8380756743075001 8.246876671552892 0.9926345446100237 0.25297979285034994 0.10128341080317994 0.12193527532786705 0.21224386492738148 0.6077059962025481 1.2165413790745618e-07 6.914873114519336 7.408800997245391 up DNHVVAAGGVEK(ub)AVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DNHVVAAGGVEKAVR 15 1 Q15274 Q15274 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] 1 97842500.0 3100500.0 12249000.0 82493000.0 True False 4703685.176912169 10063070.248126188 66188222.39203369 1.0 2.139401313999569 14.071567271745918 22.16536007148249 -6.925455219074391 0.7832106430781555 0.7847655475832751 16.259788129163912 0.9955668417983737 0.3936169376703257 0.09506751808873656 0.08975492152824231 0.3493403825156961 1.1078592975430015 1.1872571150594567e-07 6.925455219074391 15.475022581580637 DNHVVAAGGVEK(ub)AVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNHVVAAGGVEKAVR 15 1 Q15274 Q15274 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] 1 14124500.0 1657300.0 3599300.0 8867900.0 True False 1378118.3808386554 3579909.856494885 10722136.889463069 1.0 2.59767949275615 7.780272753446697 20.394268390685177 -6.949681909893039 0.5623244033419368 0.9330252789836833 9.693601890053861 0.9991760880779922 0.08307274983519437 0.08361371259264298 0.03649284196895834 0.08880132655611847 0.43103492761025375 1.1228405547892441e-07 6.949681909893039 8.760576611070178 DNHVVAAGGVEK(ub)AVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DNHVVAAGGVEKAVR 15 1 Q15274 Q15274 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] 1 51423800.0 3100500.0 8141300.0 40182000.0 True False 4013658.369992063 7688229.49822214 32869288.302136976 1.0 1.9155166657189469 8.189358752574146 21.93648639357494 -6.93309204213848 0.720957609880335 0.9146729117640561 9.58500678810067 0.9971118379122256 0.17171749371745876 0.09106385133726638 0.07004540563421904 0.15942614102084715 0.558337275651378 1.1665623556353853e-07 6.93309204213848 8.670333876336615 DNIACVILTFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DNIACVILTFK 11 0 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 36946200.0 9642200.0 14518000.0 12786000.0 False True 14627922.33924287 11927149.470348278 10258841.49569713 1.0 0.8153686623253988 0.7013191113392334 23.802221536645607 -12.8376639105513 0.04954454537899566 2.233096144410865 2.7589309734342935e-10 0.9999830883482611 0.000506059367535454 8.308754324404651 0.04436393867529953 1.6604927370655103 0.5871713922724253 1.45323580475269e-13 12.8376639105513 -2.2330961441349717 DNIK(ub)HVPGGGNVQIQNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNIKHVPGGGNVQIQNK 17 1 P27816-6;P27816;E7EVA0;P27816-2;P27816-4;H0Y2V1;F8W9U4 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 1 3828960.0 1147500.0 2184700.0 496760.0 True False 954197.0928693399 2172930.587471004 600630.2192412721 1.0 2.2772345500831954 0.6294613803895938 19.863927765339437 -6.699753361353849 1.831578941528587 1.7932857459373444 0.6343549567947785 0.4165137454458909 0.539158394829406 0.39602028302685865 2.5826271655926996 0.23484773617336405 0.6041885118457033 1.9963957591615454e-07 6.699753361353849 -1.1589307891425658 DNIQAMVIVPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNIQAMVIVPTR 12 0 P26196;Q8IV96 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 9075100.0 2610100.0 3319300.0 3145700.0 False True 3421866.376244359 2824073.3785300627 2820213.139685107 1.0 0.8253020626800749 0.8241739535079123 21.70635199306338 DNIQAMVIVPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNIQAMVIVPTR 12 0 P26196;Q8IV96 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 8869900.0 2610100.0 3545000.0 2714800.0 False True 3575124.5053003207 3388370.1782526607 2073620.1530610556 1.0 0.9477628466447011 0.5800134093195352 21.76956205458627 -6.932554690811646 0.7255182916798574 1.0050967271897773 0.4993587014575367 0.9970168799549094 0.01020764791015333 0.09133303678444278 0.07134041522599804 0.009445172857653008 0.0328201169140792 1.1680066332350174e-07 6.932554690811646 -0.5057380257322406 DNIQGITK(ub)PAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNIQGITKPAIR 12 1 P62805 P62805 HIST1H4A Histone H4 1 151292000.0 37044000.0 22676000.0 91572000.0 True False 48565042.7346063 19292829.190355718 82097007.86064944 1.0 0.39725753554434956 1.6904547641249998 25.53341489532924 -6.779963309964956 1.5359941856100003 0.6586966577077842 1.7006907195487346 0.7672674653115992 0.25488860445878675 0.2506309877198991 1.1679437084790865 0.13070077459493612 0.30841089652254705 1.65972711846134e-07 6.779963309964956 1.0419940618409504 DNIQGITK(ub)PAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNIQGITKPAIR 12 1 P62805 P62805 HIST1H4A Histone H4 1 305551000.0 107817000.0 19821000.0 177913000.0 True False 104394408.35104202 27735628.66514948 131312248.02440709 1.0 0.26568117108230765 1.2578475236226232 26.637469198398797 -6.708493113580033 1.8008136971755706 0.5478476124392527 1.2553871572902155 0.45777782023713076 0.3095138513687243 0.378141721165474 2.3895435140954215 0.13683171240056977 0.34822264939973147 1.956621792995393e-07 6.708493113580033 0.7075395448509628 DNIQGITK(ub)PAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DNIQGITKPAIR 12 1 P62805 P62805 HIST1H4A Histone H4 1 1362020000.0 285560000.0 404760000.0 671700000.0 True False 433215397.23239416 332527415.5956857 538938200.5834318 1.0 0.7675798637814912 1.244042118600701 28.690509278859682 -6.774094693977487 1.5590933544048093 0.8673863320537641 1.2471262978967612 0.7458577408878766 0.09806959479969661 0.2598640227127604 1.247192724173701 0.04956763391332888 0.11753884292546823 1.6823072092306803e-07 6.774094693977487 0.3797399658429971 DNIQGITK(ub)PAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNIQGITKPAIR 12 1 P62805 P62805 HIST1H4A Histone H4 1 427595000.0 37044000.0 184698000.0 205853000.0 True False 50740167.876458734 176537431.64539042 157234761.07561412 1.0 3.4792441380016843 3.0988222478578815 25.596624956852132 -10.147733083448108 10.844288915919783 0.9999999992850888 3.289033192929783 0.9797052586592141 0.15530658630623898 5.299535805052332e-09 4.1326110416477737e-10 0.15037495558009686 0.05012498519336568 7.11650758459784e-11 10.147733083448108 2.2890331936446944 DNIQGITK(ub)PAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNIQGITKPAIR 12 1 P62805 P62805 HIST1H4A Histone H4 1 648260000.0 107817000.0 397910000.0 142533000.0 True False 89654612.60295749 395766379.8510488 172335991.3018684 1.0 4.414344877086597 1.9222211361848376 26.417874473833074 -6.56515746985232 2.3262137948569594 3.345476174132761 1.92686111607085 0.0 1.4888541425801298 0.7450267263596373 7.562063081817742 0.5426571495500689 1.671330392371571 2.721714268933724e-07 6.56515746985232 -1.4186150580619112 DNIQGITK(ub)PAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DNIQGITKPAIR 12 1 P62805 P62805 HIST1H4A Histone H4 1 902210000.0 285560000.0 368110000.0 248540000.0 True False 369663049.2291349 347624354.9053037 203308270.23575506 1.0 0.9403816681981364 0.5499826684320153 28.461635600952132 -6.9340142182425515 0.7130764712266692 1.0051449607405696 0.4609777889925703 0.9972699531105351 0.010427903391053336 0.09060662188147842 0.0678586276213474 0.009738282060031501 0.03457796568709909 1.1640879180459758e-07 6.9340142182425515 -0.5441671717479992 DNIQGITKPAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNIQGITKPAIR 12 1 P62805 P62805 HIST1H4A Histone H4 0 135665900.0 2791900.0 56833000.0 76041000.0 False True 3660207.936798059 48353737.933298856 68173006.75677757 1.0 13.210653265671729 18.625446404669333 21.80349417981874 -8.612165297016308 0.4663764853006176 2.5305117061739748e-18 19.189668010248564 0.9954271404710938 0.4984952547045694 0.25756545275802156 0.16272526274791382 1.7606853942268186 1.1907576832066191 2.442500734462847e-09 8.612165297016308 19.189668010248564 DNIQGITKPAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DNIQGITKPAIR 12 1 P62805 P62805 HIST1H4A Histone H4 0 2785647900.0 22460900.0 2731800000.0 31387000.0 False True 34074827.41174213 2244288946.34918 25183345.6925892 1.0 65.86354552087333 0.7390601099247552 25.0222030140416 -13.939256111402567 1.1920716848602585e-10 9.533731619992812 50.60860501798302 0.0 31.552071594837518 1787583166.3206742 0.2858127735257475 1223634550.6673334 1223634521.4921422 1.1501219409643334e-14 13.939256111402567 41.0748733979902 DNIQGITKPAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNIQGITKPAIR 12 1 P62805 P62805 HIST1H4A Histone H4 0 453896900.0 2791900.0 173455000.0 277650000.0 False True 3824140.878260584 165791184.56101972 212074788.38124466 1.0 43.35383811394262 55.45684511437434 21.86670424134163 -8.820272392352123 0.6149815169531584 2.0867594372729032e-22 54.53947557375291 0.9945987889114514 1.715863391465116 0.39784487268229357 0.26144342504314483 4.851239260649564 2.155582067690107 1.5126122305241773e-09 8.820272392352123 54.53947557375291 DNIQGITKPAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DNIQGITKPAIR 12 1 P62805 P62805 HIST1H4A Histone H4 0 111463900.0 22460900.0 47805000.0 41198000.0 False True 29076077.82053045 45144609.7260277 33700386.72717728 1.0 1.5526375326369277 1.1590417020889119 24.79332933613405 -10.389725324507804 6.334904208387317 0.9999515646016124 1.355839617362847 0.5214850517309684 0.16068482495493192 0.00010995064875905954 1.0592100047704655e-05 0.15560351559597424 0.05186080425322543 4.076380125347085e-11 10.389725324507804 0.3558880527612347 DNK(ub)QAGVFEPTIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNKQAGVFEPTIVK 14 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 1 4774700.0 1583300.0 3191400.0 0.0 True False 1533039.0081546027 4465742.662931139 0.0 1.0 2.913000020988886 0.0 20.547962976141616 -6.729638466074023 1.7251184624699 2.1518026734870603 0.002115404533747862 0.5571889579985543 0.8042119914392666 0.33700077608993234 1.9647701772154529 0.3694930730073336 0.9170480297906003 1.8636379000019785e-07 6.729638466074023 -2.1496872689533126 DNLAK(ub)QQQQQQNDVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNLAKQQQQQQNDVVK 16 1 F5H157;Q15286 F5H157 RAB35 Ras-related protein Rab-35 1 2879090.0 937090.0 721100.0 1220900.0 True False 907342.5908871328 1009038.9904868227 901109.6637850998 1.0 1.112081589270772 0.9931305692418352 19.791287855237897 -6.659621725386869 1.9746752405591648 1.0721687966843934 0.9936309386465652 0.23389218464667494 0.04772623164728165 0.48528912616290587 3.637434584668125 0.019531540966611128 0.052890109018883746 2.18966801519739e-07 6.659621725386869 -0.0785378580378282 DNLAK(ub)QQQQQQNDVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNLAKQQQQQQNDVVK 16 1 F5H157;Q15286 F5H157 RAB35 Ras-related protein Rab-35 1 2900430.0 937090.0 1310500.0 652840.0 True False 779231.8551258657 1303440.0763861162 789345.8256088886 1.0 1.6727243217945418 1.0129794109628505 19.571693130672173 -10.241217930414024 3.7912741992165397 0.9995496909344737 1.3428518661147584 0.2647494323236087 0.26933973245122117 191607953.6484409 246357495.61589253 956061.6705172706 0.09856824862851177 5.738284409300696e-11 10.241217930414024 0.3433021751802847 DNLEFFLAGIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNLEFFLAGIGR 12 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 8526500.0 2366000.0 3708700.0 2451800.0 False True 3101848.912376594 3155376.416399375 2198111.2553263013 1.0 1.0172566445158573 0.7086454941617832 21.56469698533275 -6.893661130171253 1.0004495894489762 1.015156141349835 0.6801146254227677 0.9831408110991934 0.01838428406035809 0.1162237885399429 0.2048869922799306 0.013929612333156424 0.035218000719019635 1.2774351728350132e-07 6.893661130171253 -0.3350415159270672 DNLEFFLAGIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNLEFFLAGIGR 12 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 17020800.0 7943200.0 2875300.0 6202300.0 False True 7691047.463887854 4023422.2844914123 4577731.564988389 1.0 0.5231306013105212 0.5952026153111696 22.874748665306683 -10.655616102992349 6.641201671832829 1.0022758915890824 0.5591666083108886 0.9803471508467089 0.02942327650605228 0.0009954077031957647 5.161744801748827e-05 0.028601350816166927 0.00949632165823304 2.2099573739031363e-11 10.655616102992349 -0.44310928327819377 DNLEFFLAGIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DNLEFFLAGIGR 12 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 25950000.0 3767400.0 13243000.0 8939600.0 False True 5715421.2338328995 10879683.18196873 7172684.141634134 1.0 1.9035662879169015 1.2549703421989 22.446428400146544 -10.089435474702038 5.919069569963526 0.9999976385178004 1.5792683150579294 0.5153935708126297 0.264788186041268 8.251599198821553e-06 1.2695763258070645e-06 0.2563811052139774 0.08546001956751037 8.138877751635504e-11 10.089435474702038 0.579270676540129 DNLEFFLAGIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNLEFFLAGIGR 12 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 9984800.0 2366000.0 2744100.0 4874700.0 False True 3240774.138745853 2622856.5884747864 3723396.2575978795 1.0 0.8093302637529085 1.1489218619347525 21.62790704685564 -6.754371013732149 1.633851078230138 0.8884754461098887 1.1498208763111102 0.6674968367371359 0.08014388317475253 0.29247794149138534 1.5374204433556902 0.038729847118619425 0.0935914462104079 1.7604714494541334e-07 6.754371013732149 0.2613454302012215 DNLEFFLAGIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNLEFFLAGIGR 12 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 14936700.0 7943200.0 2898300.0 4095200.0 False True 6605122.743424615 2882686.2826324934 4951487.385934566 1.0 0.4364319021175195 0.7496435082699653 22.65515394074096 -10.158640533956401 5.537560737747906 1.0000089222631512 0.5930377051937032 0.6924003244381602 0.12786810276536162 1.4085323178984552e-05 2.1399637823392663e-06 0.12381047034696638 0.04126925271008848 6.939999929508393e-11 10.158640533956401 -0.40697121706944794 DNLTLWTSDMQGDGEEQNK ddPTM_RPMI8226_Bortezomib_1h_R1 2 DNLTLWTSDMQGDGEEQNK 19 0 P62258;P62258-2 P62258 YWHAE 14-3-3 protein epsilon 0 36350000.0 7146900.0 13985900.0 15217200.0 False True 9369655.110678058 11899258.236611206 13642670.117689623 1.0 1.2699782538473914 1.4560482703511524 23.159564513764465 -6.975090213799764 0.060667514764211956 0.03174131940334661 2.6989164789800744 0.9999999668004862 3.362229036421987e-05 0.0746829696813575 0.0017440073267419062 0.031393657836260885 0.04509838800975084 1.0590337146012726e-07 6.975090213799764 2.6671751595767277 DNLTLWTSDMQGDGEEQNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNLTLWTSDMQGDGEEQNK 19 0 P62258;P62258-2 P62258 YWHAE 14-3-3 protein epsilon 0 23340900.0 6347100.0 2118800.0 14875000.0 False True 6145614.7847268805 2964847.889396035 10978791.259565374 1.0 0.48243308330426 1.7864431215002172 22.551125909053397 -6.799034986629613 1.4600226111390628 0.7140796646089659 1.8039796129101666 0.8292597743810013 0.22152817832130028 0.22215087986562426 0.9350319662779547 0.11937427657947712 0.2777639739852324 1.5884187809158866e-07 6.799034986629613 1.0898999483012006 DNLTLWTSDMQGDGEEQNK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DNLTLWTSDMQGDGEEQNK 19 0 P62258;P62258-2 P62258 YWHAE 14-3-3 protein epsilon 0 27776600.0 7146900.0 9379400.0 11250300.0 False True 9789302.067710375 8964987.094471922 8593210.847201565 1.0 0.9157943061173458 0.8778164968007199 23.222774575287357 -13.999999999999998 0.10746725075364465 1.4082477965013294 0.8055368111504438 0.9997559255613234 0.0007976428147211527 12.028151617190007 0.09905406524191808 1.0707072905114694 0.0642466931198183 1.0000000000000041e-14 13.999999999999998 -0.6027109853508855 DNLTLWTSDMQGDGEEQNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNLTLWTSDMQGDGEEQNK 19 0 P62258;P62258-2 P62258 YWHAE 14-3-3 protein epsilon 0 13094000.0 6347100.0 3913800.0 2833100.0 False True 5277894.874205653 3892715.582571524 3425488.1112256385 1.0 0.7375507992014327 0.649025452925716 22.331531184487673 -13.999999999999998 0.1517683042629312 2.272631605519824 0.5535826389215788 0.9995604437367458 0.003124575643279385 11.964825298927458 0.12278038398111081 4.488271374840406 0.0861777439947121 1.0000000000000041e-14 13.999999999999998 -1.7190489665982454 DNLTLWTSDQQDDDGGEGNN ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNLTLWTSDQQDDDGGEGNN 20 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 5496300.0 1839200.0 2032700.0 1624400.0 False True 2411209.0108381365 1729429.0834025412 1456322.6703450722 1.0 0.7172456123168648 0.6039802703950804 21.201325282823777 -13.999999999999998 0.126141701507079 2.343855885006317 0.43730403502689613 0.9996634157027748 0.003055318581721776 11.944374023694918 0.11004769368854851 3.994721361293467 0.1480510501373358 1.0000000000000041e-14 13.999999999999998 -1.906551849979421 DNLTLWTSDQQDDDGGEGNN ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNLTLWTSDQQDDDGGEGNN 20 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 7993300.0 3452800.0 1076900.0 3463600.0 False True 3343192.753967165 1506911.7859593106 2556379.254227269 1.0 0.45074032425176486 0.7646520683540511 21.672795106204646 -10.219750990584132 5.681793424994041 1.0000144680109042 0.607696196302906 0.6755797384518556 0.1281539328863271 2.348790244186057e-05 3.225209426121508e-06 0.12408908382037245 0.04136150398497163 6.029051719377837e-11 10.219750990584132 -0.39231827170799816 DNLTLWTSDQQDDDGGEGNN ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNLTLWTSDQQDDDGGEGNN 20 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 5344200.0 1839200.0 1668500.0 1836500.0 False True 2519201.9425111464 1594780.1530083378 1402756.5239047555 1.0 0.6330497472618877 0.5568257551065893 21.26453534434667 -13.999999999963128 0.22089749729622815 3.223088252658152 0.516402353418902 0.9994988069868939 0.004331212094266833 13.024195556176243 0.14888508255984448 12.636123879738106 0.041935925040598614 1.0000000000849005e-14 13.999999999963128 -2.70668589923925 DNLTLWTSDQQDDDGGEGNN ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNLTLWTSDQQDDDGGEGNN 20 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 6230000.0 3452800.0 1766400.0 1010800.0 False True 2871156.1849753894 1756884.0525970515 1222153.6065888507 1.0 0.6119082137679358 0.42566601321945385 21.453200381638922 -13.999999999999373 0.09713250298328668 2.933836817034484 0.010747617014098055 0.999807992192325 0.003315194295305812 12.102928606845321 0.09222235848043016 4.727440348304839 0.37071223261281017 1.0000000000014438e-14 13.999999999999373 -2.923089200020386 DNMK(ub)WCGTTQNYDADQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNMKWCGTTQNYDADQK 17 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 1 19359100.0 1324100.0 0.0 18035000.0 True False 1813655.5524570502 0.0 13775504.442484211 1.0 0.0 7.595435871944837 20.79046905609053 -6.873758545853021 1.1140799166221793 0.41936070989584895 8.073111096589045 0.9682896973787851 0.6000452905498648 0.1332992400475759 0.3069560421570621 0.41698502332518156 0.9941554221876815 1.3373388284541712e-07 6.873758545853021 7.653750386693196 up DNNLLGK(ub)FELTGIPPAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNNLLGKFELTGIPPAPR 18 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 19234900.0 6483100.0 7111000.0 5640800.0 True False 6277297.539169516 9950459.383375121 4163305.259627311 1.0 1.585150189438298 0.6632321048427019 22.581712162522834 -6.735224896418869 1.7043031241237128 1.350082678715523 0.6632507176838875 0.5832281975004271 0.24589931199690981 0.3265442506466552 1.8604483722683436 0.1142335457850505 0.28178818685487056 1.83981901708234e-07 6.735224896418869 -0.6868319610316354 DNNLLGK(ub)FELTGIPPAPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DNNLLGKFELTGIPPAPR 18 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 11875400.0 0.0 4435900.0 7439500.0 True False 0.0 4189038.2655305075 6085587.335716189 0.0 DNNMGLVK(ub)QCLSSLYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNNMGLVKQCLSSLYK 16 1 Q9UNS2;Q9UNS2-2 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 14428200.0 4233400.0 5230200.0 4964600.0 True False 4099013.034245999 7318646.135132686 3664222.3251924813 1.0 1.7854654459470214 0.8939279515773737 21.966845146857775 -6.67411722342166 1.923257160363631 1.499581367365227 0.8974951481966822 0.2972693956601494 0.33333637023956175 0.45169163708984084 3.2250289181538485 0.13935442840814946 0.3702679471104645 2.1177894309306826e-07 6.67411722342166 -0.6020862191685448 DNNMGLVK(ub)QCLSSLYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNNMGLVKQCLSSLYK 16 1 Q9UNS2;Q9UNS2-2 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 11452800.0 4233400.0 3177500.0 4041900.0 True False 3520259.671418792 3160382.176815634 4887042.60236593 1.0 0.8977696169617754 1.3882619631853108 21.74725042229205 -6.852319428236392 1.2238829305186956 0.9453195088218058 1.4087608301223185 0.9436079364809254 0.050174437454854726 0.1549245536114739 0.4454017442148033 0.03205963590600947 0.074304599024489 1.405013741363425e-07 6.852319428236392 0.46344132130051263 DNPGVVTCLDEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNPGVVTCLDEAR 13 0 P22314-2;P22314;Q5JRR9;Q5JRS0 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 21063300.0 1142100.0 14882000.0 5039200.0 False True 1497304.1601121314 12661663.609581638 4517791.923419657 1.0 8.456306972815343 3.0172840253655107 20.513935887389014 -9.918810243946151 8.598012875634394 0.9999082121995558 5.736795520201117 0.5028011947935973 2.2204718207224556 1.0335736126803741e-07 2.9808691538085194e-08 2.1499625953095065 0.7166541984365036 1.2055625711174528e-10 9.918810243946151 4.7368873080015605 DNPGVVTCLDEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNPGVVTCLDEAR 13 0 P22314-2;P22314;Q5JRR9;Q5JRS0 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 22744100.0 1142100.0 21602000.0 0.0 False True 1564365.2340919839 20647552.211738747 0.0 1.0 13.198677496641862 0.0 20.577145948911905 -6.663844477691112 1.9592831104799757 8.827240789584572 0.05464554477972933 0.2520342005094347 5.189203623350317 0.47541175467768876 3.5122347494989103 2.136830409997035 5.755109771235459 2.1684805059292228e-07 6.663844477691112 -8.772595244804842 DNPK(ub)IVHAFDMEDLGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNPKIVHAFDMEDLGDK 17 1 Q9NZ45 Q9NZ45 CISD1 CDGSH iron-sulfur domain-containing protein 1 1 10411900.0 2216300.0 2391500.0 5804100.0 True False 2145944.7696412876 3346438.421507748 4283832.090732321 1.0 1.5594243005923831 1.9962452675090976 21.033181515134366 -6.973897342132708 0.13594228383336587 0.37968725730388564 3.1873396868083015 0.9999990537506888 0.0003965892148868583 0.07505711163093935 0.004102010064191618 0.025771205789059688 0.05796781435299974 1.0619465488386908e-07 6.973897342132708 2.807652429504416 DNPK(ub)IVHAFDMEDLGDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DNPKIVHAFDMEDLGDK 17 1 Q9NZ45 Q9NZ45 CISD1 CDGSH iron-sulfur domain-containing protein 1 1 57510700.0 4220700.0 22379000.0 30911000.0 True False 6403110.474501916 18385292.602074932 24801427.301227394 1.0 2.8713064806999262 3.8733405272312815 22.610341470688613 -8.821233236379019 0.2516771395207645 1.3419412805283992e-15 4.583921425606771 0.9991892569929333 0.03390617469875155 0.3437870115483501 0.07930262341989763 0.7113205602093668 0.40717658346162344 1.5092693884662935e-09 8.821233236379019 4.5839214256067695 DNPK(ub)IVHAFDMEDLGDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DNPKIVHAFDMEDLGDK 17 1 Q9NZ45 Q9NZ45 CISD1 CDGSH iron-sulfur domain-containing protein 1 1 39901700.0 4220700.0 10905000.0 24776000.0 True False 5463779.352435253 10298127.16373459 20267022.223227926 1.0 1.8847992386706884 3.7093412665346275 22.381467792781063 -6.959442343490858 0.4432226011684743 0.9369113149631833 4.728747478169145 0.9997489557219905 0.017873156444404733 0.07990092198915155 0.021871877534047332 0.024155230618563502 0.15108572901647216 1.0978870350041875e-07 6.959442343490858 3.791836163205962 DNPQK(ub)SYFIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNPQKSYFIR 10 1 P42768;C9J3B7 P42768 WAS Wiskott-Aldrich syndrome protein 1 14563400.0 0.0 1892400.0 12671000.0 True False 0.0 2648045.188735628 9352084.978148095 0.0 DNPQK(ub)SYFIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNPQKSYFIR 10 1 P42768;C9J3B7 P42768 WAS Wiskott-Aldrich syndrome protein 1 8583100.0 0.0 2296200.0 6286900.0 True False 0.0 2283829.9148399876 7601461.7226587245 0.0 DNPTK(ub)SLQEEEPCPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DNPTKSLQEEEPCPR 15 1 Q9UL63;C9J7E8;Q9UL63-2 Q9UL63 MKLN1 Muskelin 1 7134700.0 1898200.0 2414500.0 2822000.0 True False 2457257.3191159223 2280130.952483922 2308424.9561652103 1.0 0.9279170458648883 0.9394315109806004 21.228617511100115 -9.866343619587509 5.811296321418349 1.0000000171265118 0.9336742784245021 0.9778956373564933 0.004700760699481364 1.0414310222735495e-09 2.1007462539528315e-10 0.004551493128713135 0.0015171639919101083 1.3603679153041472e-10 9.866343619587509 -0.06632573870200964 DNQLSEVANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNQLSEVANK 10 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2;S4R349;S4R402;S4R341 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 6948690.0 664190.0 3800500.0 2484000.0 False True 870759.5220251089 3233480.214232973 2226979.5082105123 1.0 3.7134020730694153 2.5575138162500575 19.731914818652246 -9.807491379225386 6.9774604722408125 0.9999999898571169 3.1354579446597954 0.8198462402615245 0.4718894048139707 7.636260441937681e-08 1.1709270713301811e-08 0.456904954928159 0.15230165050798825 1.557788956740045e-10 9.807491379225386 2.1354579548026784 DNQLSEVANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNQLSEVANK 10 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2;S4R349;S4R402;S4R341 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 10185300.0 2837500.0 2349100.0 4998700.0 False True 2747425.1156689725 3287107.8803946692 3689390.5122144106 1.0 1.196432201790617 1.3428538929680995 21.38964872866963 -6.974356508510747 0.11308916287259778 0.7068923299991019 1.8361382483530142 0.9999995695822216 9.197275163584132e-05 0.074912785518957 0.0033500657498209126 0.01119558224124409 0.021985578659326214 1.0608243782979182e-07 6.974356508510747 1.1292459183539123 DNSCVQEIAEK(ub)QALAVGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNSCVQEIAEKQALAVGNK 19 1 E9PPJ1;Q8NG31-3;Q8NG31-4;Q8NG31-2;Q8NG31;H0YCZ2 E9PPJ1 CASC5 Protein CASC5 1 13292100.0 1325900.0 2249300.0 9716900.0 True False 1738267.740033865 1913713.2077027268 8711488.399086457 1.0 1.1009312107842741 5.011591826997111 20.72921888247177 -6.912442101569616 0.8789514164399455 0.8880696503453072 5.544274867147757 0.9918107489449478 0.16902082951106973 0.1028248283802336 0.1301756080135954 0.1400728320662638 0.39352439937539274 1.22337020307754e-07 6.912442101569616 4.65620521680245 up DNSCVQEIAEK(ub)QALAVGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNSCVQEIAEKQALAVGNK 19 1 E9PPJ1;Q8NG31-3;Q8NG31-4;Q8NG31-2;Q8NG31;H0YCZ2 E9PPJ1 CASC5 Protein CASC5 1 12294000.0 1325900.0 2739800.0 8228300.0 True False 1816121.0611002222 2618746.5766929816 6284945.00715791 1.0 1.4419449412180276 3.4606421024325518 20.79242894399466 -6.94184045259503 0.6422124646082108 0.9778638449217301 4.035820368595864 0.9983951742865577 0.04290838717010219 0.086936934307085 0.050860593997146146 0.04237539432860194 0.17238540471458302 1.1432982728227708e-07 6.94184045259503 3.057956523674134 up DNSGMIDK(ub)NELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNSGMIDKNELK 12 1 O75340;A0A024QZ42;O75340-2 O75340 PDCD6 Programmed cell death protein 6 1 3665400.0 727000.0 1693000.0 1245400.0 True False 953104.0402780146 1440410.9992623127 1116537.9547203605 1.0 1.5112841184076333 1.1714754187745056 19.862274180912554 -10.367010935416477 5.418913526331051 0.9998731983877379 1.3413797685910753 0.5736863671133532 0.1387263207099935 0.00021259734933200763 2.4833601959403328e-05 0.13437073345796205 0.04477372748253312 4.295256112911052e-11 10.367010935416477 0.3415065702033374 DNSGMIDK(ub)NELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNSGMIDKNELK 12 1 O75340;A0A024QZ42;O75340-2 O75340 PDCD6 Programmed cell death protein 6 1 5843910.0 735910.0 1552500.0 3555500.0 True False 712548.9398667685 2172421.346180544 2624207.887286366 1.0 3.0488030009373674 3.682845823582359 19.442629580360638 -9.627770336941134 0.3296173564379448 2.6655895239521317e-21 3.865061256762561 0.99861575697464 0.04259666462445621 0.9875432586453303 0.13728704045120366 1.2608683154727913 0.19951996679996456 2.356295007432903e-10 9.627770336941134 3.865061256762561 DNSGMIDK(ub)NELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DNSGMIDKNELK 12 1 O75340;A0A024QZ42;O75340-2 O75340 PDCD6 Programmed cell death protein 6 1 14003100.0 1605100.0 0.0 12398000.0 True False 2435054.0485282093 0.0 9947529.865763562 1.0 0.0 4.085137195117303 21.21552236408692 -6.841973905678424 1.273103116696798 0.468069023711261 4.224915876355514 0.9278091900051256 0.4671489543573436 0.16650575345454421 0.523357176893664 0.28762041305779745 0.6630490309780392 1.4388850301963824e-07 6.841973905678424 3.7568468526442524 DNSGMIDK(ub)NELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNSGMIDKNELK 12 1 O75340;A0A024QZ42;O75340-2 O75340 PDCD6 Programmed cell death protein 6 1 3761900.0 727000.0 1045900.0 1989000.0 True False 995791.5464362781 999688.6796712147 1519239.164740843 1.0 1.0039136034533367 1.5256598333033358 19.925484242435445 -6.908544422051872 0.9055904305112015 0.9830924723728137 1.5910287533681455 0.990360503998386 0.024239021133160926 0.10538862765800015 0.1440470403035082 0.01970304912599694 0.05385611021559845 1.234399047522146e-07 6.908544422051872 0.6079362809953318 DNSGMIDK(ub)NELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNSGMIDKNELK 12 1 O75340;A0A024QZ42;O75340-2 O75340 PDCD6 Programmed cell death protein 6 1 4205910.0 735910.0 1555100.0 1914900.0 True False 611941.7713407207 1546722.3676368187 2315296.7365027615 1.0 2.5275646149274307 3.783524585076308 19.223034855794914 -7.305392475138998 0.18721408629720784 8.511011437461976e-17 5.928433285954889 0.9999839082522842 0.004565714605464563 0.11147185164399809 0.011875164927385754 0.10467974133038031 0.2408829288698956 4.950026510517877e-08 7.305392475138998 5.928433285954889 DNSGMIDK(ub)NELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DNSGMIDKNELK 12 1 O75340;A0A024QZ42;O75340-2 O75340 PDCD6 Programmed cell death protein 6 1 19070000.0 1605100.0 2524900.0 14940000.0 True False 2077833.59125117 2384387.0954345185 12221073.297345227 1.0 1.147535156556381 5.881641989427215 20.986648686179368 -6.913544906062856 0.8712541312801484 0.8693409740224982 6.542190860792689 0.992191824541986 0.20034335454179694 0.10212005593094232 0.12639982879503497 0.16695486753240896 0.4730116548644332 1.2202676385092586e-07 6.913544906062856 5.672849886770191 up DNSHPFVGLAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNSHPFVGLAFK 12 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 48123900.0 14682900.0 14266900.0 19174100.0 False True 19249424.089405853 12138334.131940637 17190148.062954593 1.0 0.6305816774342413 0.8930214214780271 24.198311947640526 -10.097808496489339 5.816083039884398 1.0000013480879597 0.761801549456117 0.5234446342989807 0.10714057685571056 1.8729394844454158e-06 2.9050540344745354e-07 0.1037390048470676 0.03457947248875962 7.983466431144891e-11 10.097808496489339 -0.2381997986318427 DNSHPFVGLAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNSHPFVGLAFK 12 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 38701800.0 11147200.0 5586500.0 21968100.0 False True 10793338.237668775 7817218.583212632 16213995.581126576 1.0 0.7242632826914032 1.5022225028156437 23.36363780467059 -6.810890072675187 1.4107365119808009 0.8498836986934903 1.5161185255194196 0.8621538399125311 0.11957166976316151 0.20558751497189226 0.8062332665935178 0.06664200337556483 0.15409915365824828 1.545645619241437e-07 6.810890072675187 0.6662348268259293 DNSHPFVGLAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNSHPFVGLAFK 12 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 49866300.0 14682900.0 14483300.0 20700100.0 False True 20111564.92045285 13843379.916131672 15811162.711941661 1.0 0.6883293254844318 0.7861726710218452 24.261522009163418 -10.520308169517358 8.989214278381644 1.0000128082095092 0.7372509982531386 0.9057954565720245 0.03994437854891405 1.0253909086715802e-05 5.471855633601624e-07 0.038677860703171196 0.01289199274121241 3.017809563432236e-11 10.520308169517358 -0.26276180995637066 DNSHPFVGLAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNSHPFVGLAFK 12 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 26463000.0 11147200.0 5892800.0 9423000.0 False True 9269390.704691159 5861054.316770785 11393305.732970662 1.0 0.6323020038204404 1.2291321075941495 23.144043080104865 -6.740036681661217 1.6866289436160211 0.7812285954627247 1.2294797865179603 0.6050687590130843 0.1544908693224192 0.31775493654651105 1.7748865821827209 0.07246320867203457 0.1778064382138211 1.8195471683506164e-07 6.740036681661217 0.4482511910552356 DNSTMGYMAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNSTMGYMAAK 11 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 28062700.0 1935700.0 15238000.0 10889000.0 False True 2537721.445345468 12964549.797258774 9762310.734663567 1.0 5.108736351279827 3.846880339277975 21.27510228882879 -9.749329665762554 7.743366757381311 1.0000000629323875 4.477808311767724 0.9101378601647543 0.515150559711346 7.623688976586522e-09 0.0 0.4987923846378507 0.16626412821261685 1.781026306567792e-10 9.749329665762554 3.477808248835337 DNSTMGYMAAK ddPTM_RPMI8226_Bortezomib_2h_R1 3 DNSTMGYMAAK 11 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 29280100.0 9145090.0 3136910.0 16998100.0 False True 8854784.123719182 4389494.521769544 12545787.677930634 1.0 0.4957201057009926 1.4168372150738735 23.07802570437181 -6.758060870303125 1.619780742244891 0.7063782934772576 1.4198813760910904 0.682983366365883 0.21204672800041743 0.28619474392666266 1.4794735459340769 0.10331205470791685 0.24875176075470065 1.745577477288727e-07 6.758060870303125 0.7135030826138329 DNSTMGYMAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNSTMGYMAAK 11 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 26849700.0 1935700.0 11183000.0 13731000.0 False True 2651380.600325593 10688898.082764307 10488020.598821778 1.0 4.0314461384577145 3.9556827856151004 21.338312350351682 -10.25597827165131 4.76275332193405 0.9991437577966313 3.99356446204281 0.9995198313110336 0.03093025929981512 10931315.822788779 150.57001561350987 102646.04983276023 0.010588250451683677 5.546534623373233e-11 10.25597827165131 2.9944207042461786 DNSTMGYMAAK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNSTMGYMAAKK 12 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 6277700.0 2608800.0 2080600.0 1588300.0 True False 2525985.0719849253 2911394.4301856677 1172276.582021357 1.0 1.1525778447684518 0.46408690020490867 21.268414682465096 -6.848566305870975 1.2419000279132277 1.081336021123807 0.4373024779273007 0.9382032362885385 0.07339370497921556 0.1590431659746658 0.4727383564610633 0.04625923146177826 0.10695895977881968 1.4172083227714182e-07 6.848566305870975 -0.6440335431965063 down DNSTMGYMAAK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNSTMGYMAAKK 12 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 3929300.0 1399800.0 1417700.0 1111800.0 True False 1917343.8881726325 1355061.326293031 849215.7382397527 1.0 0.7067388039526402 0.44291258520615034 20.870677686333845 -7.04949063727261 0.1996759223608375 1.1626007088418124 8.038272004563486e-10 0.9999948198464309 0.0005178381356345193 0.07258835347188901 0.006594329323811572 0.009094006585004841 0.02771930474144176 8.922968559412882e-08 7.04949063727261 -1.1626007080379852 down DNSTMGYMAAK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNSTMGYMAAKK 12 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 7167900.0 2608800.0 3418500.0 1140600.0 True False 2169332.789435764 3400083.861980876 1379094.1864614584 1.0 1.5673408333376209 0.6357227407327192 21.048819957899372 -6.741897843663729 1.6800206475854669 1.3368233890764025 0.6349760106106328 0.6133386094914965 0.2383634487497789 0.31438246360775657 1.743046485029469 0.11221621112583252 0.2747678735117948 1.8117662127751606e-07 6.741897843663729 -0.7018473784657697 DNSTMGYMAAK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DNSTMGYMAAKK 12 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 14379330.0 4792100.0 4808420.0 4778810.0 True False 6203467.916413142 4540827.200059118 3909115.614731345 1.0 0.731982056044006 0.630150049521269 22.564643518226884 -13.999999999999998 0.13416119359772016 2.2752516048806575 0.49480087892031427 0.9996272012841395 0.00301182431497256 11.932547559326036 0.11429575321124197 3.9989512112260104 0.12058835358368865 1.0000000000000041e-14 13.999999999999998 -1.7804507259603433 DNSTMGYMMAK ddPTM_RPMI8226_Bortezomib_1h_R1 4 DNSTMGYMMAK 11 0 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 122430800.0 13731100.0 48088700.0 60611000.0 False True 18001605.072161544 40914053.40828448 54339555.14176622 1.0 2.2728002999885675 3.018595004386539 24.10162221112264 -8.75241047624846 0.20064696487434586 5.974512849134038e-15 3.842314882146214 0.9996274392633642 0.016086089653286773 0.29819771968605463 0.05963504840444261 0.5760407781661907 0.38465353029217814 1.7684367187346974e-09 8.75241047624846 3.842314882146208 DNSTMGYMMAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 DNSTMGYMMAK 11 0 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 19466570.0 5605300.0 1800670.0 12060600.0 False True 5427362.819686094 2519686.921369997 8901567.04975556 1.0 0.46425621523414745 1.640127506764032 22.371819925519784 -6.782823284130231 1.524800447060099 0.6977621876460959 1.650292168362643 0.7772784968691802 0.22684796520742118 0.2462108171850189 1.130827651555767 0.11715370630797607 0.2757966018794429 1.6488331707486516e-07 6.782823284130231 0.9525299807165472 DNSTMGYMMAK ddPTM_RPMI8226_Carfilzomib_1h_R1 4 DNSTMGYMMAK 11 0 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 111475700.0 13731100.0 51644800.0 46099800.0 False True 18807858.739025 49362961.969484575 35211976.69518351 1.0 2.624592339534104 1.8721948725678752 24.16483227264553 -10.062972451916956 4.880991482304316 0.9999666782921764 2.2483936060635727 0.7858986581420668 0.30716497968174844 0.00011138363783407626 2.1382820517845386e-05 0.2974191069702754 0.09913707089760423 8.65022786992535e-11 10.062972451916956 1.2484269277713964 DNSTMGYMMAK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNSTMGYMMAKK 12 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 17387500.0 6626000.0 6932300.0 3829200.0 True False 8686750.166275285 5898027.86189376 3432991.1162800686 1.0 0.6789682849164664 0.395198555336382 23.050385115073976 -7.287264031552172 0.2177889095517185 1.1551859728450418 3.892895137395782e-14 0.9999706818696729 0.0013377527829803355 0.10459867653884625 0.013227257362168577 0.01716239894593954 0.045884861822067385 5.1610250671516925e-08 7.287264031552172 -1.155185972845003 down DNSTMGYMMAK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 2 DNSTMGYMMAKK 12 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 26483400.0 10491900.0 7606300.0 8385200.0 True False 10158840.377475696 10643535.256330492 6188864.569392101 1.0 1.0477116344823636 0.6092097463322809 23.27623239337416 -6.879939624603786 1.080099333329599 1.0295496462477953 0.5781648029282481 0.9736382767076016 0.031893622739897556 0.12768527060702262 0.2725892215556694 0.022747057553065844 0.05500146217098059 1.31844001467152e-07 6.879939624603786 -0.4513848433195472 DNSTMGYMMAK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 DNSTMGYMMAKK 12 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 36025300.0 8525800.0 8858500.0 18641000.0 True False 12934261.919470327 7277631.463223602 14956598.179359447 1.0 0.5626630656263708 1.1563549797027721 23.624694394654682 -6.709355212091782 1.7978376671570298 0.7309540234694789 1.15491413838455 0.46191072373891107 0.1843100852193727 0.376360283835456 2.3709923915717774 0.08160122299517274 0.20744176279208895 1.9527416431961554e-07 6.709355212091782 0.42396011491507113 DNSTMGYMMAK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DNSTMGYMMAKK 12 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 18175630.0 7401020.0 5602860.0 5171750.0 True False 10137377.099045163 5355307.119019653 3950289.165534664 1.0 0.5282734445702003 0.38967566530663444 23.273181088180806 -13.999999999999872 0.17170140638744705 3.389711932145864 0.26960497322199994 0.9995105352053563 0.005779698089852849 12.108509918482733 0.13124921515651594 9.639358413814287 0.11127020330439298 1.0000000000002946e-14 13.999999999999872 -3.120106958923864 DNSTMGYMMAK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DNSTMGYMMAKK 12 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 29990530.0 10491900.0 15216100.0 4282530.0 True False 8724479.719978938 15134127.849140625 5177987.222818508 1.0 1.734673967375233 0.593500975302973 23.056637668808435 -6.732875024551858 1.7128595861443887 1.4407012716999632 0.5938286287577805 0.5725133504818822 0.30877503034205334 0.3308647428921338 1.903019475320602 0.14278463910469705 0.35314781349561836 1.8498008533041855e-07 6.732875024551858 -0.8468726429421827 DNSTMGYMMAK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DNSTMGYMMAKK 12 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 35475700.0 11616300.0 10806000.0 13053400.0 True False 15037529.341505812 10204636.600762583 10677815.13919453 1.0 0.6786112511578795 0.7100777592315098 23.842064216628923 -9.988081406252928 6.048524397866984 1.000000231535699 0.6943445054823917 0.9921140208464877 0.01284614812804475 4.0100706851907405e-08 6.7107956739695715e-09 0.01243823889307553 0.004146076480218648 1.0278236198507585e-10 9.988081406252928 -0.3056557260533074 DNTAK(ub)LFDSTTLEHQK(ub)TFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNTAKLFDSTTLEHQKTFR 19 2 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 2 10597600.0 1229300.0 1843100.0 7525200.0 True False 1190276.5443848001 2579059.4416395254 5554124.368839073 1.0 2.1667733047470277 4.666247012125865 20.182865372152722 -6.958679326727716 0.4536626893996962 0.9223472116392911 6.010368177813024 0.9997180395980088 0.025680284710949637 0.0801762980380061 0.022900189327081075 0.03359564459451494 0.2066407936275943 1.0998176202763325e-07 6.958679326727716 5.088020966173732 DNTAK(ub)LFDSTTLEHQK(ub)TFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DNTAKLFDSTTLEHQKTFR 19 2 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 2 87370300.0 4050200.0 9908100.0 73412000.0 True False 6144449.509282256 8139922.142661372 58902086.022377305 1.0 1.324760197046881 9.586226712970054 22.550852332435724 -6.9151891571423425 0.8596358075174244 0.7842434213420459 10.781492321209209 0.9927371185054554 0.3386106364855266 0.10108610709442144 0.12088954782314432 0.28454421334414437 0.8168156329022516 1.2156564056686492e-07 6.9151891571423425 9.997248899867163 up DNTAK(ub)LFDSTTLEHQK(ub)TFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNTAKLFDSTTLEHQKTFR 19 2 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 2 9812800.0 1229300.0 2702100.0 5881400.0 True False 1022217.4172237742 2687543.250975141 7111173.547478899 1.0 2.6291307560325095 6.956615518049022 19.963270647587 -6.954149435339058 0.5112673783519168 0.9211789907274763 8.854830427419289 0.9994879557097184 0.05687813247060772 0.081861138354704 0.029388875505122085 0.06537005814228083 0.35718854313657167 1.1113492600022982e-07 6.954149435339058 7.933651436691813 DNTAK(ub)LFDSTTLEHQK(ub)TFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DNTAKLFDSTTLEHQKTFR 19 2 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 2 87282400.0 4050200.0 7848200.0 75384000.0 True False 5243063.741377786 7411440.770877734 61664885.50515883 1.0 1.4135706023154577 11.76123132330151 22.321978654528174 -6.915321756011216 0.8587107863082758 0.7309806412740787 13.26264302075621 0.9927795750507484 0.42301959131346667 0.10100299823705329 0.12045785109988741 0.35571723234823016 1.0222112866089228 1.215285297893721e-07 6.915321756011216 12.531662379482132 up DNTEVAYLK(ub)TLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNTEVAYLKTLTK 13 1 A0A3B3ISG5;P14735;P14735-2 A0A3B3ISG5 IDE Insulin-degrading enzyme 1 36631300.0 12496000.0 16985000.0 7150300.0 True False 10390977.666662555 16893498.433741473 8645394.670748191 1.0 1.6257852702292874 0.8320097442308311 23.308828065180247 -6.696495812514103 1.8431502216216324 1.3899057895674223 0.83450181264733 0.40108730477385257 0.26432365264142516 0.4028437760499902 2.6580665570603523 0.1145111657936037 0.29579669912640044 2.0114265923683067e-07 6.696495812514103 -0.5554039769200922 DNTINLIHTFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNTINLIHTFR 11 0 O15144;H7C3F9 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 58455900.0 15983300.0 15166600.0 27306000.0 False True 20954261.08249738 12903802.398943752 24480637.057647448 1.0 0.6158080377132461 1.1682892067282473 24.32074031231274 -6.719685163168902 1.7602678084107288 0.7661834049023195 1.1674221540170182 0.5110725667563909 0.16167608335866382 0.3559502730710009 2.1552752260231594 0.07292992027069026 0.1831616842663936 1.9068425607921552e-07 6.719685163168902 0.4012387491146987 DNTINLIHTFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNTINLIHTFR 11 0 O15144;H7C3F9 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 37463800.0 6483200.0 3355600.0 27625000.0 False True 6277394.364724266 4695508.5792228235 20389183.76776423 1.0 0.748002802820414 3.2480329549376368 22.58173441551777 -6.882075700179986 1.0681126421890956 0.8390643323862638 3.4324456806076813 0.9753233033969598 0.1765432112997289 0.12580919784075983 0.26128742070688815 0.12707194244683517 0.3089901351318882 1.3119711944974224e-07 6.882075700179986 2.5933813482214174 up DNTINLIHTFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DNTINLIHTFR 11 0 O15144;H7C3F9 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 55412400.0 13973100.0 34190000.0 7249300.0 False True 21198214.27044389 28088527.372310724 5816472.677518942 1.0 1.325042148077247 0.27438503089520594 24.3374394020338 -6.823623099740726 1.3561597929060238 1.1745821271645052 0.24962222166134124 0.8925078511995861 0.14399526594577786 0.18881462094535942 0.6813443253552824 0.08341675939141215 0.19209856193106395 1.5009868942771141e-07 6.823623099740726 -0.9249599055031639 down DNTINLIHTFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNTINLIHTFR 11 0 O15144;H7C3F9 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 40310700.0 15983300.0 5039300.0 19288100.0 False True 21892757.9424415 4816647.0632633595 14732648.030888833 1.0 0.2200109769599089 0.6729461893116713 24.38395037383563 -10.102924815600876 5.652332275606429 1.0000047050825678 0.4464785831496504 0.6656965380613659 0.1849100261337873 1.0963845396952488e-05 1.7400437022636288e-06 0.1790398856180084 0.059679454313535316 7.8899669570216e-11 10.102924815600876 -0.5535261219329174 DNTINLIHTFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNTINLIHTFR 11 0 O15144;H7C3F9 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 12802900.0 6483200.0 3058300.0 3261400.0 False True 5391068.054457966 3041824.330874981 3943343.6609901893 1.0 0.5642340812892622 0.731458705613885 22.362139690952045 -10.072048585343815 5.058130078165928 1.0000071290749235 0.6478463934502057 0.8553434858095039 0.06826916700874205 5.48857236560665e-06 1.0069096030975084e-06 0.06610267437143214 0.022033778906344635 8.471326385113302e-11 10.072048585343815 -0.35216073562471784 DNTINLIHTFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DNTINLIHTFR 11 0 O15144;H7C3F9 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 37753900.0 13973100.0 16014300.0 7766500.0 False True 18088453.40097919 15123090.127298933 6353076.691019531 1.0 0.8360631941302548 0.3512227690331788 24.10856572412625 -6.951771566571587 0.539049329315684 1.0071830844882097 0.15774957864937592 0.9993330437425605 0.007113646685046735 0.08278218059431434 0.033078666216073555 0.007834457958179221 0.04014558229883299 1.1174508583085625e-07 6.951771566571587 -0.8494335058388338 down DNTNVNADVQK(ub)LQQQLQDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNTNVNADVQKLQQQLQDIK 20 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 8256800.0 2245300.0 2682700.0 3328800.0 True False 2943610.043516128 2282451.6170826955 2984367.7081043287 1.0 0.7753919790123824 1.013846149451072 21.489155131497494 -11.065564179224987 11.473723109549452 1.5956995733656751 0.8946190642317272 0.20660561271071864 0.09734850743557362 0.04124448958966638 0.00023568331886864212 0.002620711682607216 0.03141909567301045 8.598759866367167e-12 11.065564179224987 -0.7010805091339479 DNTNVNADVQK(ub)LQQQLQDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNTNVNADVQKLQQQLQDIK 20 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 55403500.0 7364500.0 16751000.0 31288000.0 True False 7130717.978623498 23439761.655310977 23092734.180119723 1.0 3.2871530925187074 3.2384865380102306 22.7656159155656 -10.109721478989751 4.606785642914162 0.9998239276238383 3.2628198152834784 0.9996532057177603 0.019868037939104133 6921591.393044861 4.841805724064612 13156.688791308017 0.006801357805915053 7.767450977954673e-11 10.109721478989751 2.26299588765964 DNTNVNADVQK(ub)LQQQLQDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DNTNVNADVQKLQQQLQDIK 20 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 66586200.0 7105200.0 41264000.0 18217000.0 True False 10779107.85969885 33900116.8028965 14616401.965205241 1.0 3.1449835407662032 1.3559936643600483 23.3617344415923 -6.601580393572567 2.1856088934414233 2.441077621162665 1.3619738340961065 0.02500599724904573 0.9267577199544813 0.636058796048326 5.745003354010098 0.35175653550627556 1.0300915783765325 2.5027623115553444e-07 6.601580393572567 -1.0791037870665583 DNTNVNADVQK(ub)LQQQLQDIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNTNVNADVQKLQQQLQDIK 20 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 42969500.0 7364500.0 12599000.0 23006000.0 True False 6123908.052667771 12531126.686294308 27816448.23227457 1.0 2.0462630363686385 4.5422707188029765 22.546021190999877 -6.956457746889691 0.4827821873024283 0.9416295796749842 5.751458504513372 0.9996153959273308 0.029141430319687325 0.08099174618978204 0.02599856060499605 0.035393995404750404 0.20588186528099403 1.1054580156891064e-07 6.956457746889691 4.809828924838388 DNTNVNADVQK(ub)LQQQLQDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DNTNVNADVQKLQQQLQDIK 20 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 45321200.0 7105200.0 27234000.0 10982000.0 True False 9197821.464430757 25718403.959389977 8983388.684835702 1.0 2.796140809956639 0.976686568615808 23.13286076368475 -6.64918206289196 2.011955478223618 2.166315334673658 0.9844108922474661 0.19053774724570627 0.7667767126517168 0.5105423535780481 3.960557658697336 0.309220584901635 0.8490088203768204 2.2429414512906506e-07 6.64918206289196 -1.181904442426192 DNTSVYHISGK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 DNTSVYHISGKK 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 29796600.0 6550600.0 14363300.0 8882700.0 True False 8587900.036100635 12220351.627704877 7963603.41287501 1.0 1.4229732037325353 0.9273050896492399 23.033873967523512 -6.680731153125569 1.8994943388762817 1.2674468988381542 0.929189909011646 0.3273999808198954 0.17923782766115487 0.43689071525793227 3.0483773877701386 0.07570224602950874 0.19945780190696072 2.0857816716667832e-07 6.680731153125569 -0.3382569898265082 DNTSVYHISGK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 DNTSVYHISGKK 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 43082200.0 7894700.0 15501000.0 19686500.0 True False 7644087.0698403 21690630.136647098 14530015.067659386 1.0 2.8375697370360093 1.9008175776787621 22.865912780725807 -9.993957212872472 5.567448705339997 0.9999965696664026 2.3691936573586414 0.7401597717145849 0.3824274676503556 1.628425592365894e-05 2.9424627774092687e-06 0.37028472956317293 0.1234279344445323 1.0140112822232306e-10 9.993957212872472 1.3691970876922388 DNTSVYHISGK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 DNTSVYHISGKK 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 81768700.0 9058600.0 15125100.0 57585000.0 True False 13742558.472367868 12425907.732054321 46203299.50959786 1.0 0.9041917308948743 3.3620595177017973 23.712147282034778 -6.897830051695945 0.9748975021641039 0.8916379848940106 3.6089685106555267 0.9854550575397121 0.1370936949888811 0.11301975560522427 0.1865708160611577 0.10588546987088464 0.2726117939964274 1.265231361492606e-07 6.897830051695945 2.717330525761516 up DNTSVYHISGK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNTSVYHISGKK 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 20990000.0 6550600.0 6407900.0 8031500.0 True False 8972533.84330878 6124777.789908374 6134625.113934675 1.0 0.6826140638606668 0.6837115603090803 23.097084029046403 -10.26180631483145 5.476944673001208 1.000028693849824 0.6831628122351321 0.9999909995669108 0.0004480510489079786 1.5699867404402798e-07 2.1160827991458038e-08 0.0004338627920421195 0.00014460785421493622 5.4725997361080206e-11 10.26180631483145 -0.31686588161469187 DNTSVYHISGK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNTSVYHISGKK 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 33517600.0 7894700.0 12152000.0 13470900.0 True False 6564792.844510315 12086534.764016846 16287602.907595737 1.0 1.8411144190366928 2.4810535980912087 22.646318056160084 -7.121001232921764 0.1317681423515145 1.5100726878196199e-13 4.244965202483706 0.9999989602940812 0.0006183906024118421 0.08006178939079467 0.004767949513742118 0.04970047483084012 0.09987215619257697 7.568307464456124e-08 7.121001232921764 4.244965202483555 DNTSVYHISGK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DNTSVYHISGKK 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 45997600.0 9058600.0 17351300.0 19587700.0 True False 11726536.271701371 16385684.90198147 16022939.586774375 1.0 1.3973166945744768 1.3663829809183416 23.483273604127227 -10.28122814413981 5.1747568351718405 0.9999271567258207 1.3818498377463977 0.9951021226206214 0.012628635718060648 1.061583548912379e-05 1.474508203034054e-06 0.012229947266535618 0.004075874651745545 5.233254503605252e-11 10.28122814413981 0.381922681020577 DNVK(ub)IAMDQYGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DNVKIAMDQYGK 12 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 3613700.0 1674000.0 1939700.0 0.0 True False 1392005.170774098 1929250.4510996968 0.0 1.0 1.3859506355330815 0.0 20.408733139588612 -6.860966281325805 1.3814411150716996 1.2036546447720347 1.7903191992234293e-20 0.9096610677579953 0.17553853481757492 0.16457921160394484 0.6314424226810783 0.10249175341471818 0.21360878765018299 1.3773163997486437e-07 6.860966281325805 -1.2036546447720347 down DNYQAFCK(ub)WLYDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DNYQAFCKWLYDAK 14 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 4304240.0 844840.0 1252100.0 2207300.0 True False 1157200.178942538 1196778.0818590007 1685981.200770469 1.0 1.0342014317286308 1.456948617404412 20.142207020794103 -6.922968739753827 0.8023810925073591 0.9916329805908451 1.5300085874105844 0.9949672160156324 0.014742897378853917 0.09645564844143062 0.09678547322910348 0.01290661390932097 0.039831657059329326 1.194074050077107e-07 6.922968739753827 0.5383756068197393 DPAAVTESK(ub)EGTEASASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPAAVTESKEGTEASASK 18 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 2984400.0 920690.0 687810.0 1375900.0 True False 1207033.5059746422 585191.4290623815 1233535.0665647534 1.0 0.4848178829881425 1.0219559444364488 20.203034293662785 -10.965456656797496 12.680858743069603 1.089944966138295 0.7533869137122956 0.2193964673243527 0.21928569532934444 0.09674148641049307 0.000263528713868213 0.036835880186728495 0.07077415383933877 1.0827877734836772e-11 10.965456656797496 -0.33655805242599934 DPAAVTESK(ub)EGTEASASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPAAVTESKEGTEASASK 18 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 3352950.0 462960.0 872090.0 2017900.0 True False 448263.58821149205 1220320.0848892713 1489351.4542976117 1.0 2.7223270347658057 3.3224903683118945 18.773987790599527 -9.631274816394054 0.29540179392735505 5.1466269613493406e-15 3.5611233002851828 0.9987862801501057 0.03429338473085986 1.0100495741394424 0.12267386816598985 1.163113592595375 0.2153318803919679 2.337357718372254e-10 9.631274816394054 3.5611233002851774 DPAAVTESK(ub)EGTEASASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DPAAVTESKEGTEASASK 18 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 3172660.0 920690.0 804570.0 1447400.0 True False 1261093.9737117146 769021.4370428048 1105553.9301387118 1.0 0.6098050209370064 0.8766626065818001 20.266244355185677 -10.07976136596222 5.344421701547521 1.0000031002342096 0.7432338137591739 0.5524522061101605 0.10894415313760508 4.024458421357994e-06 6.929385820487015e-07 0.10548599731220046 0.03516157423060177 8.322209302362083e-11 10.07976136596222 -0.2567692864750357 DPAAVTESK(ub)EGTEASASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPAAVTESKEGTEASASK 18 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 3466660.0 462960.0 1484700.0 1519000.0 True False 384971.7526054817 1476701.6264101244 1836615.876937538 1.0 3.835870077261085 4.770780880694117 18.554393066033803 -9.34330354494182 0.3574996480644405 1.0997301620407147e-23 4.993208275337105 0.9982737174435562 0.06661461015905898 0.7210652792412834 0.14042815578049453 1.214014020821766 0.26605450471188224 4.5362445043085827e-10 9.34330354494182 4.993208275337105 DPAEGDGAQPEETPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPAEGDGAQPEETPR 15 0 Q14697;F5H6X6;Q14697-2;E9PKU7;E9PNH1 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 5356940.0 1507500.0 524840.0 3324600.0 False True 1459645.2376637794 734411.3490044428 2453787.5241378825 1.0 0.5031437297599091 1.6810848696805722 20.477186338391437 -6.792097817875974 1.4878045302298601 0.7230652098178721 1.6943729296901493 0.8081026628437655 0.21151724261200194 0.2322300643056518 1.015453019413848 0.1118863115587655 0.2615741258509614 1.6139949893640782e-07 6.792097817875974 0.9713077198722772 DPANYILHAVLVHSGDNHGGHYVVYLNPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPANYILHAVLVHSGDNHGGHYVVYLNPK 29 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 73026000.0 18243000.0 10387000.0 44396000.0 False True 17663885.95071334 14534583.267489411 32767355.74854883 1.0 0.8228417749098094 1.8550479684922079 24.074299426513203 -6.862686998596778 1.1721892748548193 0.9031184775938219 1.9076341183443 0.9568176469319208 0.09365113940733592 0.14405341747232614 0.3746125524248552 0.06224562525311661 0.14575754721638529 1.371870133726461e-07 6.862686998596778 1.004515640750478 DPANYILHAVLVHSGDNHGGHYVVYLNPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DPANYILHAVLVHSGDNHGGHYVVYLNPK 29 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 214178000.0 41139000.0 44255000.0 128784000.0 False True 62410870.66376045 36357349.48410681 103329785.95196761 1.0 0.5825483461043606 1.6556376293588093 25.89529400238223 -6.801229527446342 1.4510870206694644 0.7700320416129913 1.6708704342198688 0.8356783230095163 0.17903782682408723 0.21900884526834422 0.9103364656891685 0.09706245235491158 0.22554433356394882 1.5804125602383525e-07 6.801229527446342 0.9008383926068775 DPANYILHAVLVHSGDNHGGHYVVYLNPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DPANYILHAVLVHSGDNHGGHYVVYLNPK 29 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 119321400.0 41139000.0 39802800.0 38379600.0 False True 53255246.47092505 37587739.19052682 31394906.6079512 1.0 0.7058034969577697 0.5895176285606226 25.66642032447468 -13.999999999999998 0.1281806937738327 2.3979440391467963 0.4228410424387006 0.9996539279306852 0.0032135856348038663 11.939894841693038 0.1111528188828534 4.212401581229997 0.14813772913709441 1.0000000000000041e-14 13.999999999999998 -1.9751029967080957 DPAQHEK(ub)LIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPAQHEKLIVR 11 1 K7EJR8;Q9P0W2-2;Q9P0W2-3;Q9P0W2 K7EJR8 HMG20B SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related 1 8569900.0 2244900.0 3255000.0 3070000.0 True False 2173636.878296135 4554738.474600754 2265874.9019741635 1.0 2.0954458953471153 1.0424348816488298 21.05167951721588 -6.637045616271243 2.0564096708556026 1.7180004139943108 1.046887820054696 0.1430043083397683 0.4690657283414357 0.5407810704383933 4.367462174098751 0.18604764459774564 0.5190262141176613 2.3065049114546568e-07 6.637045616271243 -0.6711125939396148 DPAQHEK(ub)LIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPAQHEKLIVR 11 1 K7EJR8;Q9P0W2-2;Q9P0W2-3;Q9P0W2 K7EJR8 HMG20B SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1-related 1 6331900.0 2244900.0 2947600.0 1139400.0 True False 1866733.8159323612 2931720.6937472094 1377643.2720096335 1.0 1.5705081617557395 0.7379966336130007 20.832084792650157 -6.722285707078654 1.7514220773661702 1.3462451808444607 0.7391536801440841 0.5231525825286892 0.2400066850512877 0.35088553918260507 2.1047760383850664 0.10876469580218111 0.2722746187855018 1.895458555379375e-07 6.722285707078654 -0.6070915007003765 DPDDQYK(ub)LTEDTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPDDQYKLTEDTR 13 1 Q9UK45;A0A087X2I5 Q9UK45 LSM7 U6 snRNA-associated Sm-like protein LSm7 1 10308400.0 3850600.0 2506200.0 3951600.0 True False 5048173.8892634455 2132284.729091087 3542726.338423776 1.0 0.42238733765215014 0.701783737275476 22.267330175535538 -10.473537676773326 6.238741340640687 1.0002274715192458 0.562085537463826 0.7661084421569067 0.11406310250798114 0.00036107034226580273 3.046932781103559e-05 0.11049730444799347 0.036813708035846694 3.360952101862443e-11 10.473537676773326 -0.4381419340554199 DPDDQYK(ub)LTEDTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPDDQYKLTEDTR 13 1 Q9UK45;A0A087X2I5 Q9UK45 LSM7 U6 snRNA-associated Sm-like protein LSm7 1 22030000.0 4242700.0 6786300.0 11001000.0 True False 4108017.8108365643 9496104.980086993 8119508.077074185 1.0 2.3116026797734817 1.9765026470079285 21.970011005982688 -10.205088103182856 4.938944924788413 0.9998643499566991 2.144052663392441 0.9395445380571973 0.13680401551692797 0.0002043644753273395 3.289180658831944e-05 0.13247530058425674 0.044153306148422576 6.23608314301732e-11 10.205088103182856 1.1441883134357416 DPDDQYK(ub)LTEDTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DPDDQYKLTEDTR 13 1 Q9UK45;A0A087X2I5 Q9UK45 LSM7 U6 snRNA-associated Sm-like protein LSm7 1 12404400.0 3850600.0 4500800.0 4053000.0 True False 5274270.878552318 4301939.7738447245 3095764.8741551735 1.0 0.8156463467468932 0.5869559879345635 22.33054023705843 -6.968221311688576 0.29761947802216177 1.0408015053356774 0.3546591525715104 0.9999649940062584 0.0009995788804230096 0.07688415559896264 0.01108490834913232 0.0038395705899296043 0.020562559744064554 1.0759167985484594e-07 6.968221311688576 -0.686142352764167 DPDDQYK(ub)LTEDTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPDDQYKLTEDTR 13 1 Q9UK45;A0A087X2I5 Q9UK45 LSM7 U6 snRNA-associated Sm-like protein LSm7 1 18352800.0 4242700.0 9956800.0 4153300.0 True False 3527993.0334786503 9903160.742129937 5021735.82731052 1.0 2.8070238937987027 1.4233973195686893 21.750416281416964 -6.578518740612133 2.2722573755939215 2.2316118901076956 1.4266976715292279 0.0 0.7853137893394091 0.7038653024413863 6.8331426108326125 0.2904356970791413 0.8783958462512302 2.6392544311862087e-07 6.578518740612133 -0.8049142185784677 DPEEIEKEEQAAAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPEEIEKEEQAAAEK 15 1 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 13438880.0 5551600.0 488780.0 7398500.0 False True 5375367.496792204 683952.4029540272 5460610.89975761 1.0 0.1272382592189616 1.0158581535153226 22.35793195987291 -11.823006827168172 13.647516216432342 0.9192182423380323 0.6143933857302494 0.0 0.4270778765932329 0.0 0.0 0.0 0.12284857411834871 1.5031183366801293e-12 11.823006827168172 -0.3048248566077829 DPEEIEKEEQAAAEK(ub)AVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPEEIEKEEQAAAEKAVTK 19 2 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 1 9412700.0 1959600.0 3031500.0 4421600.0 True False 1897393.5706308077 4241993.7590636555 3263450.314843311 1.0 2.2356952319878274 1.7199648851757963 20.85558753299948 -10.49713757100547 5.594157208498375 0.9984962703543219 1.977830058581679 0.8273820463334166 0.2105460324263512 0.003953289423075348 0.0003553631305050616 0.20409665715496025 0.06795343976644144 3.183189026570364e-11 10.49713757100547 0.9793337882273572 DPELGLK(ub)SVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPELGLKSVQK 11 1 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 1 4331800.0 1183700.0 1521500.0 1626600.0 True False 1551842.1629671047 1294498.1307605482 1458295.035448961 1.0 0.8341686813596315 0.9397186584109284 20.565550398573183 -10.411816107622297 5.199840169673029 1.0000988163594167 0.8869436698921189 0.6046994803226867 0.043090597689705204 4.9406705694176856e-05 5.588637336332128e-06 0.04175870201078967 0.013907430602527427 3.874216553135118e-11 10.411816107622297 -0.11315514646729774 DPELGLK(ub)SVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPELGLKSVQK 11 1 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 1 7421900.0 1575800.0 1728600.0 4117500.0 True False 1525777.0915493108 2418838.9945299146 3039003.2276477604 1.0 1.5853161041196175 1.9917740569573523 20.54111277631542 -7.761026906045182 0.1096409169287916 1.0129106205833248e-19 3.266263004521107 0.9999913186722467 0.0011994070446712862 0.13605787838226674 0.01418052985533384 0.17457274404414005 0.2265676176598036 1.733696585927334e-08 7.761026906045182 3.266263004521107 DPELGLK(ub)SVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DPELGLKSVQK 11 1 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 1 4189800.0 1183700.0 1037200.0 1968900.0 True False 1621345.8782897135 991373.0744382681 1503886.3707683503 1.0 0.611450701366709 0.9275543182400623 20.628760460096075 -9.943372426513347 6.603332935712271 1.0000000242886034 0.7695025098033819 0.414843472725531 0.12904876119800424 4.615756691121585e-08 7.47209469609464e-09 0.12495093970647388 0.04165030858071199 1.139272392635584e-10 9.943372426513347 -0.2304975144852215 DPELGLK(ub)SVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPELGLKSVQK 11 1 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 1 6110800.0 1575800.0 2236600.0 2298400.0 True False 1310347.5197764772 2224550.99186966 2778984.8133991035 1.0 1.697680163693621 2.1207998423755177 20.321518051749695 -8.977692280445412 0.14017085822295197 3.700395794260736e-08 2.9241857806013356 0.9998761824226852 0.0051421420859800995 0.4613370906075659 0.04534164346114622 0.534627934154641 0.3445063426884236 1.0527075060198218e-09 8.977692280445412 2.9241857435973775 DPELGLK(ub)SVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DPELGLKSVQK 11 1 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 1 24226900.0 3381300.0 6312600.0 14533000.0 True False 4377159.505387566 5961298.2607786255 11888143.121172559 1.0 1.3619102190453065 2.715949260368557 22.061563526625054 -6.946411733855055 0.5969395779867362 0.9846402659351028 3.1621696319746633 0.9988887612006728 0.024619189675745567 0.08495941172275351 0.04217787755110747 0.0253445501444481 0.1136779811678358 1.1313272972797526e-07 6.946411733855055 2.1775293660395603 up DPETLVGYSMVGCQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPETLVGYSMVGCQR 15 0 P49327;A0A0U1RQF0;A0A0U1RRG3 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 11953400.0 2480100.0 4670800.0 4802500.0 False True 3251435.1173225683 3973934.8466358036 4305583.368832931 1.0 1.222209486962848 1.3242101452045623 21.632645204281516 -13.630972894265799 0.10772610691229094 7.64910828271627e-17 1.521097226410233 0.9997641723868829 0.0020786245197534203 10.64716399763413 0.0958447965535554 2.38831942511396 0.1708303966027953 2.3389832176703385e-14 13.630972894265799 1.521097226410233 DPETLVGYSMVGCQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DPETLVGYSMVGCQR 15 0 P49327;A0A0U1RQF0;A0A0U1RRG3 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 8616000.0 2480100.0 2662000.0 3473900.0 False True 3397059.9921824164 2544384.0379431793 2653436.3672163 1.0 0.7489959093447032 0.7810978826757838 21.695855265804408 -10.112981906447272 7.544921956598134 1.0000000476978455 0.7650468960939896 0.9861922154098874 0.013105575732930206 1.051732577076347e-08 1.2405448754694689e-09 0.012689421691691877 0.004229806379674901 7.709355870712412e-11 10.112981906447272 -0.23495315160385588 DPFVPSSAAK(ub)PSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPFVPSSAAKPSK 13 1 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 17081100.0 7866100.0 2238800.0 6976200.0 True False 10312533.275420751 1904779.7667740476 6254369.744435658 1.0 0.1847053207880517 0.6064823819131366 23.29789543871734 -10.286532492914022 5.035136268446164 1.0001544963136673 0.39559385140578196 0.732475964307369 0.17218976416194565 0.0002987118959979772 4.232685892526204e-05 0.16676409419976349 0.05557400741544136 5.1697257782273946e-11 10.286532492914022 -0.6045606449078853 DPFVPSSAAK(ub)PSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPFVPSSAAKPSK 13 1 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 26377900.0 6165300.0 7898900.0 12313700.0 True False 5969585.926214602 11052971.962219324 9088372.56691832 1.0 1.8515475108050197 1.5224460589482434 22.509199433324362 -10.346124893186502 5.622713375562245 0.9998553220336429 1.6869967848766367 0.8531607034992695 0.1343551051097223 0.00024372163978303993 2.8342813903451774e-05 0.13011570323316185 0.04336292371398916 4.506870785802362e-11 10.346124893186502 0.6871414628429938 DPFVPSSAAK(ub)PSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DPFVPSSAAKPSK 13 1 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 20668900.0 7866100.0 6551700.0 6251100.0 True False 10774409.743359564 6262224.23042537 4774718.925445696 1.0 0.5812127420051828 0.4431536426752686 23.36110550024023 -13.999999999999998 0.1551049396785414 3.042582596248154 0.29982799842457053 0.9995501045433799 0.0050219671049014656 11.980601057631699 0.12427340898727107 7.366537524641869 0.12987311031189375 1.0000000000000041e-14 13.999999999999998 -2.742754597823583 DPFVPSSAAK(ub)PSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPFVPSSAAKPSK 13 1 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 21910600.0 6165300.0 14146400.0 1598900.0 True False 5126720.119100087 14070190.53535946 1933222.597521681 1.0 2.7444818926119288 0.37708760232868477 22.289604708758638 -6.709254688741404 1.797642067337194 2.073282649207257 0.38272267112528185 0.46161856469281637 0.7352023922645406 0.3765984214378092 2.371791242012556 0.3255046040261554 0.827750879563503 1.9531936840579013e-07 6.709254688741404 -1.6905599780819753 DPFYMGLYQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPFYMGLYQK 10 0 A0A1W2PQT3;A0A1W2PPH1;A0A1W2PQY8;P23368;A0A1W2PQF8;A0A1W2PQH3;P23368-2;A0A1W2PQ37;A0A1W2PR68 A0A1W2PQT3 ME2 NAD-dependent malic enzyme, mitochondrial 0 16059900.0 4190700.0 5469100.0 6400100.0 False True 5494048.282796531 4653131.598384832 5737879.046094248 1.0 0.8469404269625997 1.0443808919665345 22.389438158486584 -6.699732885097374 1.8316384024271524 0.904932924820219 1.0437943869581192 0.4164059873352892 0.06461128954907977 0.3960719751695711 2.5831145677677845 0.02814264860666935 0.07240428243213404 1.996489888092468e-07 6.699732885097374 0.13886146213790018 DPFYMGLYQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DPFYMGLYQK 10 0 A0A1W2PQT3;A0A1W2PPH1;A0A1W2PQY8;P23368;A0A1W2PQF8;A0A1W2PQH3;P23368-2;A0A1W2PQ37;A0A1W2PR68 A0A1W2PQT3 ME2 NAD-dependent malic enzyme, mitochondrial 0 12181200.0 4190700.0 3427500.0 4563000.0 False True 5740115.039409234 3276061.7167731966 3485313.377934877 1.0 0.5707310209431561 0.6071852835711775 22.452648220009475 -10.023020377399373 6.176489424267298 1.0000003798233954 0.5889581529550939 0.9941354935789473 0.014882390398064113 7.784053344960002e-08 1.2324059627825927e-08 0.014409825960602108 0.004803270846947078 9.483739638904512e-11 10.023020377399373 -0.4110422268683015 DPFYMGLYQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPFYMGLYQK 10 0 A0A1W2PQT3;A0A1W2PPH1;A0A1W2PQY8;P23368;A0A1W2PQF8;A0A1W2PQH3;P23368-2;A0A1W2PQ37;A0A1W2PR68 A0A1W2PQT3 ME2 NAD-dependent malic enzyme, mitochondrial 0 7030300.0 2572900.0 1812000.0 2645400.0 False True 2139480.3487960994 1802238.396346162 3198540.909052379 1.0 0.8423720261606021 1.4950083139825145 21.02882899714063 -6.842908886376786 1.268807905288317 0.9161519017268647 1.5177418669193876 0.9293455836820378 0.0739085974847779 0.16542525104847294 0.516053374931666 0.045652601089061925 0.10527187725046816 1.4357906261380738e-07 6.842908886376786 0.601589965192523 DPGGSEFDSISK(ub)NTWAPAPDTWAPAPDQTEQDQNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPGGSEFDSISKNTWAPAPDTWAPAPDQTEQDQNR 35 1 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 10690100.0 4561400.0 4493300.0 1635400.0 True False 3793006.204282535 4469093.701049779 1977354.5787647478 1.0 1.1782458188451945 0.5213159357694154 21.854910300798224 -6.834423381775931 1.3078766123981707 1.0949973867410343 0.5019681978772752 0.9144497116709421 0.08113140279398022 0.17542494866227834 0.5852543387166852 0.04867919560574718 0.11204455767119449 1.4641198147566232e-07 6.834423381775931 -0.5930291888637591 DPGTVANK(ub)KEEEDLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPGTVANKKEEEDLAK 16 2 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 10611200.0 4007500.0 2745700.0 3858000.0 True False 5253871.308685207 2336052.262654773 3458811.1685491833 1.0 0.4446344657877384 0.6583357233800914 22.32494943203487 -10.18217474981901 5.383123660986963 1.0000177550715037 0.5514850945838238 0.8545083780772497 0.08724317308238365 1.8591167495138553e-05 2.8244392787909708e-06 0.0844761794801086 0.02815761303481617 6.573932646420445e-11 10.18217474981901 -0.4485326604876799 DPGTVANK(ub)KEEEDLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DPGTVANKKEEEDLAK 16 2 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 134706000.0 23050000.0 50368000.0 61288000.0 True False 34968535.180720955 41379436.87301976 49174399.93651538 1.0 1.183333435591929 1.406247064178613 25.059554027539946 -6.968511578993008 0.2915527392660552 0.9572452161686147 1.6392373634447308 0.9999683325708815 0.0009347570027999854 0.07678867297342756 0.01074987111035819 0.0038622367966404426 0.020178765490971588 1.0751979334954046e-07 6.968511578993008 0.6819921472761161 DPGTVANK(ub)KEEEDLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DPGTVANKKEEEDLAK 16 2 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 9422100.0 4007500.0 2057600.0 3357000.0 True False 5489181.048615387 1966688.4284267055 2564145.7395852255 1.0 0.35828448925414674 0.46712719381555395 22.38815949355776 -9.945866267706108 5.582226719025681 1.0000006308366391 0.4127058415371528 0.9748867609504431 0.044434848070019115 4.2382223070036e-07 7.993414976854996e-08 0.04302391305314057 0.014341285546714695 1.1327491169570781e-10 9.945866267706108 -0.5872947892994864 DPGTVANK(ub)KEEEDLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DPGTVANKKEEEDLAK 16 2 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 131883000.0 23050000.0 48271000.0 60562000.0 True False 29838679.383427482 45584676.416380785 49540337.41859581 1.0 1.5277042201036113 1.6602724531471962 24.830680349632395 -11.578641941625696 0.24107734741541392 4.838123401821686e-10 1.7263606173515884 0.9993208868932357 0.007432021022142601 4.156196464766701 0.13732501142187079 2.212907077584425 0.06406215629028512 2.638505831518887e-12 11.578641941625696 1.726360616867776 DPIVMGVTVEAGQVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DPIVMGVTVEAGQVK 15 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 12573600.0 3425700.0 9147900.0 0.0 False True 5197037.3522167355 7515385.772131065 0.0 1.0 1.446090390119183 0.0 22.309257997324448 -6.847971819070033 1.410851797292395 1.2377487496219952 3.7494727971013244e-21 0.89225112030622 0.1984698599822368 0.1765235217141776 0.7059583574888395 0.11305516472611317 0.23943409704283627 1.419149605884952e-07 6.847971819070033 -1.2377487496219952 down DPIVNVWYSVNGER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPIVNVWYSVNGER 14 0 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 16028600.0 4895000.0 4081700.0 7051900.0 False True 4739610.904387531 5711544.095784308 5204795.837534722 1.0 1.2050660298922522 1.0981483380242378 22.176337196095048 -10.465825617665224 4.803427693670932 0.9995880431211753 1.1516071839582707 0.7283266401134127 0.04364896492554777 0.00019308487968144037 2.1472316211932903e-05 0.042376894518714785 0.014087642852973876 3.421167851472891e-11 10.465825617665224 0.15201914083709533 DPIVNVWYSVNGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DPIVNVWYSVNGER 14 0 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 36265500.0 6599700.0 20529000.0 9136800.0 False True 10012227.402698666 16865439.55619091 7330907.47519829 1.0 1.6844842688695876 0.7321954626422428 23.255259627931316 -6.713810292432542 1.7814157231107015 1.4191691856385626 0.7341578922259959 0.4831552909801309 0.2882749112826285 0.3675288601174072 2.275785866488814 0.12865914273350307 0.3253786762889856 1.932812419545491e-07 6.713810292432542 -0.6850112934125667 DPIVNVWYSVNGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DPIVNVWYSVNGER 14 0 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 6429800.0 1111200.0 1323500.0 3995100.0 False True 1522040.6690508835 1265023.3937707727 3051539.6616672426 1.0 0.8311363943774367 2.00490021306075 20.53757547760988 -6.870397893771721 1.131935587487627 0.9042549985025153 2.0741792030161443 0.9650814058538915 0.09681910292914074 0.13647668033741825 0.3265715238217824 0.06636291662294716 0.15723267909866073 1.347727550003922e-07 6.870397893771721 1.169924204513629 up DPIVNVWYSVNGER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPIVNVWYSVNGER 14 0 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 11418000.0 4895000.0 3015900.0 3507100.0 False True 4070409.3852683404 2999652.748090724 4240418.39500174 1.0 0.7369412911996254 1.0417670542792816 21.956742471529324 -6.678401736532007 1.9076510492698107 0.8333215737426029 1.040590765998731 0.3168095058501661 0.11152962921592914 0.4420699218574992 3.1089848769216153 0.0469373607580029 0.12404434198437683 2.0969991936499497e-07 6.678401736532007 0.20726919225612817 DPLK(ub)TPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPLKTPGR 8 1 Q9NRG9-2;Q9NRG9 Q9NRG9-2 AAAS Aladin 1 4405530.0 849030.0 1356600.0 2199900.0 True False 1113086.5520182159 1154200.5679853838 1972275.4509308795 1.0 1.036936944294782 1.771897654638633 20.08613434826869 -6.917337422564903 0.8442243893929701 0.9821765584444296 1.8834558604079847 0.9934092443260195 0.02885990216837679 0.09976349417785409 0.11391372976550508 0.02452150224869898 0.07168519111235985 1.209657931680322e-07 6.917337422564903 0.9012793019635551 DPLK(ub)TPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPLKTPGR 8 1 Q9NRG9-2;Q9NRG9 Q9NRG9-2 AAAS Aladin 1 5517800.0 1178300.0 1628500.0 2711000.0 True False 1140895.5114688098 2278768.542515309 2000907.7717433083 1.0 1.9973507824406993 1.7538045786220184 20.12173523826143 -10.072253516857371 4.871727344009514 0.9999735415278374 1.8755776805396724 0.9451549254206347 0.09942732138663316 69019875.61319837 1.1578306974528934 20485.18235649564 0.034036616718023265 8.467329944265649e-11 10.072253516857371 0.8756041390118351 DPLK(ub)TPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DPLKTPGR 8 1 Q9NRG9-2;Q9NRG9 Q9NRG9-2 AAAS Aladin 1 19571200.0 2029700.0 2960500.0 14581000.0 True False 3079203.290946174 2432175.644507925 11699058.958920678 1.0 0.7898717345682522 3.7993785578625454 21.55412568748904 -6.890150870627273 1.0214667001388482 0.8388804764738341 4.059012892871376 0.9809954952216099 0.1891191880506813 0.11902173572864436 0.22112203018222373 0.14103998153960678 0.35181428215762384 1.2878021012406744e-07 6.890150870627273 3.2201324163975418 up DPLK(ub)TPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DPLKTPGR 8 1 Q9NRG9-2;Q9NRG9 Q9NRG9-2 AAAS Aladin 1 4206030.0 849030.0 1234500.0 2122500.0 True False 1162939.3351730308 1179955.7080544166 1621209.214259649 1.0 1.014632210268177 1.3940617237944173 20.14934440979158 -6.915041770062018 0.8607014826120546 0.9900410986356023 1.4487752027523335 0.9926889521325204 0.015597030712753555 0.10117769006894085 0.12138371406312368 0.013096778378125826 0.03754953614467232 1.2160690345694087e-07 6.915041770062018 0.4587341041167312 DPLK(ub)TPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPLKTPGR 8 1 Q9NRG9-2;Q9NRG9 Q9NRG9-2 AAAS Aladin 1 7376100.0 1178300.0 2432900.0 3764900.0 True False 979808.657540691 2419793.4848071625 4552123.183069214 1.0 2.469659219873417 4.645930762129612 19.902140513695706 -6.965470426544494 0.34988451232891843 0.7894099217436732 6.399602242454582 0.9999225170467464 0.013183713653313304 0.07780168466773982 0.014299092066550818 0.02988148209676557 0.18707086626492928 1.0827534431434286e-07 6.965470426544494 5.610192320710909 DPLK(ub)TPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DPLKTPGR 8 1 Q9NRG9-2;Q9NRG9 Q9NRG9-2 AAAS Aladin 1 15183400.0 2029700.0 2196700.0 10957000.0 True False 2627486.6613684488 2074451.7139455061 8962938.428314028 1.0 0.789519408203233 3.4112212861419233 21.32525200958149 -6.887464146398368 1.0372895872802423 0.8504500382213473 3.62580133128279 0.979224091453131 0.17143537284596383 0.12122382169154879 0.23407084757992347 0.12633113338924243 0.3121968094426708 1.2957936686028883e-07 6.887464146398368 2.775351293061443 up DPLNPIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPLNPIK 7 0 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 5468030.0 1668000.0 709530.0 3090500.0 False True 1615050.2530170397 992849.029150069 2281005.336987344 1.0 0.6147480719533956 1.4123432585000053 20.623147625048656 -6.775349578722818 1.5537669501370714 0.7805404634392652 1.417786916273781 0.7506443061983021 0.16262976547469002 0.2578804617486836 1.229286261484333 0.08246375478735905 0.19536774621304445 1.6774532341393e-07 6.775349578722818 0.6372464528345159 DPNAFLFDHLLTLKPVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPNAFLFDHLLTLKPVK 17 1 Q7L2H7;J3KNJ2;Q7L2H7-2;H0YCQ8 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 0 4476700.0 876700.0 2411200.0 1188800.0 False True 1149362.1899748768 2051458.3587839862 1065794.3797748236 1.0 1.784866751905966 0.9272920138412767 20.132402064733366 -6.665979634660059 1.95194363438818 1.502700943571839 0.930833846612795 0.26128604300822955 0.3337065139066983 0.4703775517306248 3.45125692855235 0.13783555453442012 0.37016064521228575 2.157845594478657e-07 6.665979634660059 -0.571867096959044 DPNAFLFDHLLTLKPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPNAFLFDHLLTLKPVK 17 1 Q7L2H7;J3KNJ2;Q7L2H7-2;H0YCQ8 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 0 5946500.0 2426000.0 1553800.0 1966700.0 False True 2348987.957925263 2174240.442959955 1451562.2702646847 1.0 0.9256073176638789 0.6179521973994166 21.163607886724503 -6.94411012873511 0.6201545584382817 1.0033668313825599 0.5238895211176102 0.9986541296716603 0.006067041450718471 0.0859407600810766 0.046440837175908516 0.0061091079791386225 0.026038433757544225 1.1373388419781025e-07 6.94411012873511 -0.47947731026494966 DPNAFLFDHLLTLKPVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DPNAFLFDHLLTLKPVK 17 1 Q7L2H7;J3KNJ2;Q7L2H7-2;H0YCQ8 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 0 11327300.0 876700.0 2182700.0 8267900.0 False True 1200839.6819266647 2086261.0967763246 6315192.302745512 1.0 1.7373352398124138 5.258980359987122 20.195612126256258 -6.940831815375851 0.6517783882097733 0.9609675765613516 6.232357052783132 0.9982708435973928 0.07728020295631076 0.08738917837611004 0.05289672141499187 0.0757093621286983 0.3020072856013204 1.1459566380168878e-07 6.940831815375851 5.27138947622178 DPNLLLSVSK(ub)DHALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPNLLLSVSKDHALR 15 1 A0A5F9ZI63;O75530-3;O75530;O75530-2;E9PJK2 A0A5F9ZI63 EED Polycomb protein EED 1 11964900.0 3396900.0 3417500.0 5150500.0 True False 3289067.2688690503 4782125.572027058 3801429.5383120254 1.0 1.4539458092845263 1.155777376246595 21.64924708417774 -10.33234777987977 5.214224724393033 0.9998993499486383 1.3048615927655853 0.582265569622589 0.12172675305811011 0.00014247369686978093 1.824273856475388e-05 0.11790015832227173 0.03928714061515123 4.652134047900792e-11 10.33234777987977 0.30496224281694706 DPNLLLSVSK(ub)DHALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPNLLLSVSKDHALR 15 1 A0A5F9ZI63;O75530-3;O75530;O75530-2;E9PJK2 A0A5F9ZI63 EED Polycomb protein EED 1 11815200.0 3396900.0 3684600.0 4733700.0 True False 2824672.8581855004 3664750.328464164 5723494.783844121 1.0 1.2974069962984345 2.026250497383528 21.429652359612017 -6.955887636178875 0.48996791063648204 0.9840451710532067 2.3705167408096988 0.9995859600388949 0.008772609169251646 0.0812042391761374 0.026818665258582272 0.010493084429942857 0.06011281315876517 1.1069101347583881e-07 6.955887636178875 1.386471569756492 up DPNSPLYSVK(ub)SFEELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPNSPLYSVKSFEELR 16 1 Q9NUU7;I3L0H8;F6QDS0;Q9UMR2;H3BQK0;Q9UMR2-4;Q9UMR2-2;H3BTB3;H3BMQ5;H3BN59 Q9NUU7 DDX19A;DDX19B ATP-dependent RNA helicase DDX19A;ATP-dependent RNA helicase DDX19B 1 8144600.0 3569000.0 2300500.0 2275100.0 True False 2967781.633508213 2288106.7498865016 2750812.89112613 1.0 0.7709821787601442 0.9268919451713149 21.50095351308729 -10.067251960599526 4.767699878092869 1.000005396289202 0.8489370620720147 0.5558954776014953 0.06364989561257199 3.6510425579101953e-06 7.14274727778711e-07 0.061630947527431285 0.02054291547339145 8.565407697423724e-11 10.067251960599526 -0.15106833421718724 DPPHNNFFFFDGMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPPHNNFFFFDGMK 14 0 Q9UBE0;M0QZS6 Q9UBE0 SAE1 SUMO-activating enzyme subunit 1;SUMO-activating enzyme subunit 1, N-terminally processed 0 3541970.0 677270.0 1069400.0 1795300.0 False True 887907.52869201 909849.68848855 1609539.5777336278 1.0 1.0247122128008797 1.8127333373382528 19.76004990907062 -6.913584814515034 0.8709717640000394 0.978279331594226 1.9227826642310868 0.9922053232792191 0.033322894396736545 0.10209512864682824 0.1262639743427447 0.02777492089303096 0.07871577245986697 1.2201555100865976e-07 6.913584814515034 0.9445033326368608 DPPHNNFFFFDGMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DPPHNNFFFFDGMK 14 0 Q9UBE0;M0QZS6 Q9UBE0 SAE1 SUMO-activating enzyme subunit 1;SUMO-activating enzyme subunit 1, N-terminally processed 0 3793170.0 677270.0 1577600.0 1538300.0 False True 927675.0215335604 1507896.41557444 1174985.2222829747 1.0 1.6254576016089155 1.266591419418171 19.82325997059351 -10.12309511902825 4.656452957383155 0.9999631818371113 1.446024510520436 0.6731640616610741 0.14650650540833615 5.600681643522308e-05 1.0547438038472903e-05 0.14186600242366296 0.04728477129311509 7.531905821246874e-11 10.12309511902825 0.4460613286833246 DPQALSEHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPQALSEHLK 10 0 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 19727700.0 4313500.0 2112200.0 13302000.0 False True 4176570.3035905277 2955612.4749774914 9817807.148553846 1.0 0.70766496434565 2.350686432864219 21.993887292243727 -6.860920626716914 1.1811531392070256 0.8410021581226548 2.431630774466655 0.9547455896826221 0.15223981585380114 0.14585148276730195 0.38614199172914165 0.10049472264828108 0.23482070371757705 1.377461195847642e-07 6.860920626716914 1.5906286163440002 up DPQALSEHLK(ub)NPVIAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPQALSEHLKNPVIAQK 17 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 11404900.0 4418400.0 5640600.0 1345900.0 True False 3674095.368308409 5610212.968228558 1627321.4672615107 1.0 1.5269644377281248 0.4429175903538797 21.80895764422197 -6.774517082923161 1.5571131854033258 1.30050413188994 0.43574346087700117 0.7475564724304957 0.22238751892606412 0.25918587399465726 1.2407702642818785 0.11253331829946431 0.2667871804496411 1.680671815377262e-07 6.774517082923161 -0.8647606710129387 down DPQFQK(ub)LQQWYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPQFQKLQQWYR 12 1 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 1 17698600.0 6507200.0 6744500.0 4446900.0 True False 8531002.215814441 5738246.88985509 3986777.4456768665 1.0 0.6726345562562098 0.4673281456059562 23.02428380756773 -8.872611047018301 0.12485572132812542 1.5421735006456294 4.266156399065124e-12 0.9999284579079738 0.0018553701874075646 0.3748555721216179 0.03764336443612927 0.2542876279435963 0.181993956547031 1.3408770357344933e-09 8.872611047018301 -1.5421735006413633 DPQFQK(ub)LQQWYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPQFQKLQQWYR 12 1 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 1 31265000.0 12839800.0 9783700.0 8641500.0 True False 12432207.577151189 13690382.431321476 6378031.910556922 1.0 1.101202851252472 0.5130248888603606 23.56757916155327 -6.862553164885369 1.1726767408224599 1.0553319256791955 0.4831093051813405 0.9566743000728865 0.05344454495431354 0.14419998013534277 0.3753534372520464 0.03550581407701138 0.08313927876192596 1.372292959186873e-07 6.862553164885369 -0.5722226204978551 DPQFQK(ub)LQQWYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DPQFQKLQQWYR 12 1 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 1 69113200.0 29041300.0 14499000.0 25572900.0 True False 44057775.30342183 11911540.16879594 20518405.105999734 1.0 0.27036181665465997 0.4657158688719839 25.392893312229162 -10.389783800302022 5.1472284584124095 1.0004568442854664 0.3680388427639271 0.9331248027570224 0.0797529578530399 0.00041839945587301443 4.960197514455952e-05 0.077273998088359 0.025740156464615232 4.075831296088781e-11 10.389783800302022 -0.6324180015215393 DPQFQK(ub)LQQWYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DPQFQKLQQWYR 12 1 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 1 17079800.0 6507200.0 4609500.0 5963100.0 True False 8913087.690467885 4405837.048421901 4554738.593899506 1.0 0.4943109729677326 0.511016917153253 23.087493869090622 -9.863550483068401 6.8106711239746875 1.0000000090503776 0.5026639450821799 0.9991544557000845 0.006820173154364686 9.377687347763715e-10 1.5892928816366662e-10 0.006603604359659247 0.0022012014204193355 1.3691452275626906e-10 9.863550483068401 -0.49733606396819763 DPQFQK(ub)LQQWYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPQFQKLQQWYR 12 1 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 1 32766700.0 12839800.0 12384200.0 7542700.0 True False 10676862.599584982 12317483.85652877 9119843.696495574 1.0 1.1536613627497239 0.8541688732465349 23.347984436987545 -6.767223224952761 1.584880181972546 1.0884477265436925 0.8526503224582326 0.7198979386422343 0.06471693399756265 0.27094510989364295 1.3426632351039065 0.032193268061911286 0.07683652565233269 1.7091366025573182e-07 6.767223224952761 -0.2357974040854599 DPQFQK(ub)LQQWYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DPQFQKLQQWYR 12 1 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 1 65058900.0 29041300.0 21550600.0 14467000.0 True False 37594535.33960668 20351290.165500097 11834154.443955384 1.0 0.5413363932193507 0.3147838997623636 25.164019634321612 -10.38086417367941 0.15175231269319703 1.8048304334859193 1.1182241110798105e-20 0.9996931559513137 0.004992995468026987 2.1134601698180626 0.07710796853692661 0.8420207030578138 0.19926890299962824 4.160407075712714e-11 10.38086417367941 -1.8048304334859193 DPQFSLISATIK(ub)SMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPQFSLISATIKSMK 15 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 8150200.0 1028400.0 4967200.0 2154600.0 True False 1348242.3590397655 4226113.121993951 1931662.6603825972 1.0 3.13453519217705 1.432726577258966 20.362648426939252 -6.589583880315077 2.229403583051711 2.4450799192033843 1.4375479986757287 0.0 0.9250664229555119 0.6710798322093224 6.286906198287609 0.34638252429118793 1.031782906519598 2.572859790272963e-07 6.589583880315077 -1.0075319205276556 DPQFSLISATIK(ub)SMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPQFSLISATIKSMK 15 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 14272100.0 6110100.0 4809400.0 3352600.0 True False 5916138.219999647 6729818.500689677 2474453.4841558915 1.0 1.137535711714673 0.4182548466820708 22.49622432814699 -6.857172849700943 1.199835518743404 1.0741371481531201 0.3852417538149347 0.9501183024894101 0.06962753481301695 0.14974728121802 0.411240920190584 0.045308205933619373 0.10545574348892275 1.3893995385480827e-07 6.857172849700943 -0.6888953943381855 down DPQFSLISATIK(ub)SMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DPQFSLISATIKSMK 15 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 5784900.0 1028400.0 2608900.0 2147600.0 True False 1408627.2714650177 2493630.171521402 1640381.1112103746 1.0 1.7702554977002158 1.1645246009644024 20.425858488462143 -10.114691865968505 4.610823704727481 0.9999645020570349 1.4673900492610006 0.44253965137699025 0.24728860311433318 172384631.33168927 2.8658552023929307 70822.46652322623 0.08465346633111195 7.679061292324703e-11 10.114691865968505 0.4674255472039657 DPQQEPMEEIENLK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPQQEPMEEIENLKK 15 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 43770500.0 17188000.0 19885000.0 6697500.0 True False 22533634.448828787 16918235.511122894 6004506.946956492 1.0 0.7507992352295499 0.26646864093726275 24.4255766887669 -7.001802204305491 0.43751735649328993 1.018106601314425 4.584881106904375e-17 0.9997869408997491 0.004445344681351439 0.07472833603845642 0.020738573479595263 0.006271333939570226 0.03769981761261855 9.958588694585234e-08 7.001802204305491 -1.018106601314425 down DPQQEPMEEIENLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPQQEPMEEIENLKK 15 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 71150000.0 24929000.0 29389000.0 16832000.0 True False 24137642.540444728 41124180.9616104 12423194.250823827 1.0 1.7037364312899754 0.5146813418090719 24.524781442985 -6.746342499371653 1.663290917685119 1.415615279871752 0.5129494841884077 0.6331181673423533 0.2956774169466305 0.3064697352179805 1.6669621456819865 0.14049567004959423 0.342417641734601 1.7933187969324106e-07 6.746342499371653 -0.9026657956833444 DPQQEPMEEIENLK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 DPQQEPMEEIENLKK 15 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 76727000.0 27545000.0 35825000.0 13357000.0 True False 41787778.80923899 29431748.847997416 10716983.095418932 1.0 0.7043147467194465 0.2564621379935485 25.316577739788336 -7.155714066465411 0.3985000784044488 1.0287053343286312 1.5223259839140999e-12 0.9997618348948779 0.004717118888707225 0.08257824615102027 0.022434103245495517 0.007810426169223784 0.04058114531864248 6.986922620877691e-08 7.155714066465411 -1.0287053343271089 down DPQQEPMEEIENLK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DPQQEPMEEIENLKK 15 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 53586000.0 17188000.0 25085000.0 11313000.0 True False 23542868.088234887 23976661.754997987 8641102.398548607 1.0 1.0184256932985951 0.36703694580299834 24.48878675028979 -6.900393342530103 0.9588110464282479 1.0267908739760105 0.29812197528386913 0.9867600271875102 0.034843784848962875 0.11111525933622468 0.17580579780720196 0.027236278771557966 0.07100240984233727 1.2577857133923922e-07 6.900393342530103 -0.7286688986921415 down DPQQEPMEEIENLK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DPQQEPMEEIENLKK 15 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 83441900.0 33178400.0 40655800.0 9607700.0 True False 27589309.652336486 40436779.135855496 11616625.649014343 1.0 1.4656683927729588 0.4210553216227559 24.71760602182294 -6.785485614051575 1.5140562394194792 1.2617896823117112 0.4112426147339153 0.7864812973766457 0.19744551178300393 0.2421294151095633 1.0964977749894136 0.102670265935295 0.2412175010695404 1.6387563439770722e-07 6.785485614051575 -0.8505470675777959 down DPQQEPMEEIENLK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DPQQEPMEEIENLKK 15 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 74018000.0 27545000.0 36340000.0 10133000.0 True False 35657545.49312408 34317647.05457269 8288897.973360059 1.0 0.9624231443858139 0.232458456091949 25.087704061880785 -6.917575726579183 0.8425241337320332 1.0175568392107697 0.12107263246458598 0.9934801434448305 0.02852733453232007 0.09961970425867646 0.11316565388912547 0.024268602487691287 0.07109210324481073 1.208994355974377e-07 6.917575726579183 -0.8964842067461837 down DPQTEEFK(ub)VK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPQTEEFKVK 10 1 O43719;Q5H918;Q5H919 O43719 HTATSF1 HIV Tat-specific factor 1 1 4663300.0 1413300.0 1652000.0 1598000.0 True False 1852849.9864166684 1405528.039445565 1432654.2890983901 1.0 0.758576274252939 0.7732165580598791 20.821314649494674 -10.79663325880243 10.557702853535941 1.0016684855061677 0.765896416157226 0.9970753593011681 0.00597687083608905 0.00023601479437852986 4.546203548141205e-06 0.005818765228789087 0.0019290267675504773 1.5972273610455917e-11 10.79663325880243 -0.23577206934894168 DPQTEEFK(ub)VK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPQTEEFKVK 10 1 O43719;Q5H918;Q5H919 O43719 HTATSF1 HIV Tat-specific factor 1 1 6227300.0 1498100.0 2278100.0 2451100.0 True False 1450543.6355184792 3187757.2101345584 1809083.3785761788 1.0 2.1976293108860068 1.2471761167870996 20.468162264928495 -10.451073699420085 5.158065971964886 0.9989349226196895 1.7224027138365643 0.43511046811185106 0.38802089165686426 0.004758769169720875 0.0005064319922877433 0.37619269551223555 0.12523320428062268 3.5393727311967503e-11 10.451073699420085 0.7234677912168748 DPQTEEFK(ub)VK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DPQTEEFKVK 10 1 O43719;Q5H918;Q5H919 O43719 HTATSF1 HIV Tat-specific factor 1 1 16485500.0 4145700.0 7399800.0 4940000.0 True False 6289329.991267467 6079247.8750987165 3963606.834721082 1.0 0.9665970593909935 0.6302113007624696 22.584474902841876 -6.926081567566307 0.7782848361202654 1.0059262789101953 0.5675738410955125 0.9957104359796082 0.010937924998456246 0.09472419799043351 0.0880267380189077 0.00974176241266315 0.031118638916076725 1.1855460624256431e-07 6.926081567566307 -0.4383524378146828 DPQTEEFK(ub)VK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DPQTEEFKVK 10 1 O43719;Q5H918;Q5H919 O43719 HTATSF1 HIV Tat-specific factor 1 1 4726600.0 1413300.0 1414400.0 1898900.0 True False 1935835.2029964123 1351907.1312046717 1450418.9290730956 1.0 0.6983585839910863 0.7492471088592884 20.884524711017566 -10.440521910574699 6.009170647069835 1.0001200106770531 0.7238028464251954 0.9751718823695612 0.020775153281671496 3.341700742058789e-05 3.111279419032264e-06 0.02012414018306657 0.0067051518895683 3.626419901458525e-11 10.440521910574699 -0.2763171642518577 DPQTEEFK(ub)VK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPQTEEFKVK 10 1 O43719;Q5H918;Q5H919 O43719 HTATSF1 HIV Tat-specific factor 1 1 5739800.0 1498100.0 2665500.0 1576200.0 True False 1245736.527082839 2651140.4224396776 1905776.13247462 1.0 2.1281710576857655 1.5298388471737328 20.24856754036277 -10.185489545454177 5.617733911711272 0.9999779781336379 1.8290049524297998 0.7190677529148538 0.24426810207118027 6.737444629519566e-05 9.76870390440716e-06 0.23651783723492364 0.07883719094425522 6.523947455695411e-11 10.185489545454177 0.8290269742961619 DPQTEEFK(ub)VK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DPQTEEFKVK 10 1 O43719;Q5H918;Q5H919 O43719 HTATSF1 HIV Tat-specific factor 1 1 16012700.0 4145700.0 5009300.0 6857700.0 True False 5366690.3739642305 4730528.051471403 5609668.9659440685 1.0 0.8814609604498365 1.045275314029409 22.355601224934325 -6.712596743317698 1.7860501094386871 0.9273188879398744 1.0449191013803596 0.4773976411222195 0.049931860510117346 0.3698709489435759 2.3015601985365044 0.022234864866235278 0.05630769827383289 1.9382208303277987e-07 6.712596743317698 0.11760021344048521 DPSGTK(ub)GFAAFLTELAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DPSGTKGFAAFLTELAER 18 1 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 40912300.0 1441300.0 12149000.0 27322000.0 True False 2186557.473144171 9980916.029429754 21921794.724341974 1.0 4.564671247848632 10.025711646545208 21.06022983913838 -6.964904537024075 0.35969379514791133 0.5277729218286542 14.249662301929352 0.9999111558310889 0.0349858425953034 0.07799345156353378 0.01497473795896436 0.07331364538390171 0.4665269527243701 1.0841651999459278e-07 6.964904537024075 13.721889380100697 DPSGTK(ub)GFAAFLTELAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DPSGTKGFAAFLTELAER 18 1 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 31004300.0 1441300.0 7398000.0 22165000.0 True False 1865791.2622704578 6986294.796635339 18131197.43210556 1.0 3.7444139319924807 9.717698758028234 20.83135616123083 -6.958357535482336 0.45799641798669194 0.8223619039299798 12.879737309361245 0.9997043428959262 0.06257914587292754 0.08029316806478323 0.02333941046234302 0.08085138225278622 0.49356508390699244 1.1006328340186138e-07 6.958357535482336 12.057375405431264 DPSLEK(ub)SIQFALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPSLEKSIQFALR 13 1 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8 F8WF16 PPHLN1 Periphilin-1 1 6084550.0 1879550.0 2501200.0 1703800.0 True False 2464108.2515880927 2128030.709601237 1527507.1200036537 1.0 0.863610885694548 0.6199026033126551 21.232634206281823 -6.962187695975361 0.4034254992936921 1.0129011450134577 0.46166425929335825 0.9998429155866935 0.0019705112125324494 0.07892878313978297 0.018310909269261235 0.0031351928806980373 0.02039328354830972 1.0909687331822472e-07 6.962187695975361 -0.5512368857200995 DPSLEK(ub)SIQFALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPSLEKSIQFALR 13 1 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8 F8WF16 PPHLN1 Periphilin-1 1 9249540.0 5472900.0 2882000.0 894640.0 True False 4550958.840579183 2866474.093967791 1081705.0876520087 1.0 0.6298615729961174 0.23768729306159675 22.117739107781272 -7.494125802635512 0.343896853638149 1.0611257789267305 2.1761746416396617e-11 0.9994625231759992 0.007216020189944988 0.12122034887715674 0.03766201089894245 0.020238676127575284 0.06506408019240523 3.2053406948932016e-08 7.494125802635512 -1.0611257789049688 down DPSQIDNNEPYMK(ub)IPCNDSK ddPTM_RPMI8226_Bortezomib_1h_R1 2 DPSQIDNNEPYMKIPCNDSK 20 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 79702800.0 16204700.0 28469400.0 35028700.0 True False 21244518.626538016 24221876.492852047 31404266.143016774 1.0 1.140147108939188 1.4782291232425246 24.340587318619416 -6.956221958115079 0.4857603615081361 0.9923090144643406 1.6403008059758548 0.9996034055697752 0.003997529701799704 0.08107935058772255 0.026335692597353376 0.004823943204263895 0.027884886304156763 1.1060583580198411e-07 6.956221958115079 0.6479917915115142 DPSQIDNNEPYMK(ub)IPCNDSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPSQIDNNEPYMKIPCNDSK 20 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 12131900.0 5085700.0 1953200.0 5093000.0 True False 4924257.237271439 2733122.94580344 3758990.5132750534 1.0 0.5550325285845302 0.7633619309778246 22.23147469776766 -10.083075477020309 4.904920752970034 1.000009763544398 0.6591972297809009 0.7810932891377699 0.08505012239113025 118206060.96032181 9.715005894907298 14472.525919814825 0.02911491909348261 8.258944030475668e-11 10.083075477020309 -0.3408125337634972 DPSQIDNNEPYMK(ub)IPCNDSK ddPTM_RPMI8226_Bortezomib_8h_R1 2 DPSQIDNNEPYMKIPCNDSK 20 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 504245100.0 107796900.0 8927200.0 387521000.0 True False 163535778.30900908 7334071.411468034 310927304.4935116 1.0 0.044846892143748124 1.901279999450633 27.285031061746846 -6.766869986065116 1.5865901337248376 0.44996365140399663 1.9104709301674423 0.7183957822669387 0.40223902661122696 0.2715180761004586 1.348407940159094 0.19989916204368152 0.47719245828393714 1.7105273158433449e-07 6.766869986065116 1.4605072787634457 DPSQIDNNEPYMK(ub)IPCNDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DPSQIDNNEPYMKIPCNDSK 20 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 83728100.0 16204700.0 15571000.0 51952400.0 True False 22196015.505551513 14883021.733588744 39682313.113264054 1.0 0.6705267316949884 1.7878124613554622 24.403797380142308 -6.8277254190394085 1.3379669266138008 0.8236497816700158 1.8165193221273255 0.9012551860206239 0.14729814234236677 0.18364095736599734 0.643725501331466 0.0864565679363885 0.1989964397161102 1.4868754162456124e-07 6.8277254190394085 0.9928695404573097 DPSQIDNNEPYMK(ub)IPCNDSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPSQIDNNEPYMKIPCNDSK 20 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 18972800.0 5085700.0 1046100.0 12841000.0 True False 4228984.884710771 1040464.4516654075 15525993.729924263 1.0 0.24603172629607709 3.6713287356632676 22.011879973201935 -6.848991610711751 1.2398681651898362 0.5979577508850782 3.8056757754799433 0.9388339370636701 0.3634544766215505 0.15857167652559648 0.4695874399055345 0.22943357525965782 0.5306176839525952 1.4158211291805596e-07 6.848991610711751 3.207718024594865 up DPSQIDNNEPYMK(ub)IPCNDSK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DPSQIDNNEPYMKIPCNDSK 20 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 701012900.0 107796900.0 105558000.0 487658000.0 True False 139545212.04457244 99683604.50706051 398909247.7936267 1.0 0.7143462899695932 2.8586380137944842 27.056157383839295 -6.8733321098441005 1.1163740532043303 0.8346996424154163 2.9924031305936323 0.9678943883599598 0.1703430875429647 0.13369729442167125 0.30941147667812907 0.11816696669925385 0.28148891640611906 1.3386526133008517e-07 6.8733321098441005 2.157703488178216 up DPSQLNSK(ub)QGNGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPSQLNSKQGNGK 13 1 Q9NXG2 Q9NXG2 THUMPD1 THUMP domain-containing protein 1 1 2630180.0 863360.0 1120600.0 646220.0 True False 835953.1093793699 1568061.4238517985 476955.59581555193 1.0 1.8757767705606863 0.5705530495240987 19.673062494777533 -6.725881300471442 1.7379394521609517 1.5294298063467069 0.5718498342046525 0.5402148523152571 0.3682900604450615 0.3440098439155554 2.0335734044805327 0.1680552511198007 0.41902539477862066 1.8798305339170324e-07 6.725881300471442 -0.9575799721420544 DPVPGYSVPAAEHSTITAWGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPVPGYSVPAAEHSTITAWGK 21 0 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 13242600.0 2301800.0 4955500.0 5985300.0 False True 3017682.0906629083 4216158.716387703 5365998.5710516805 1.0 1.397151386301769 1.7781855112090044 21.525009396930933 -6.971629762228131 0.21573790242382088 0.8145469852421403 2.3714964365099287 0.9999924567787954 0.0008725844671893755 0.07577733573848446 0.007106568334948588 0.010907187060690967 0.038976637268509466 1.0675057863541264e-07 6.971629762228131 1.5569494512677884 DPVQEAWAEDVDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPVQEAWAEDVDLR 14 0 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 66731200.0 7707200.0 27001000.0 32023000.0 False True 10104213.836630974 22972556.04907365 28709567.14630644 1.0 2.273561943611176 2.841345958279819 23.268453740692575 -9.503826847538033 0.2330816496010384 1.5084376474247164e-17 3.2473061318822274 0.9992263455702346 0.021414854150471407 0.9170022397984497 0.09324520868660965 0.9353349431579534 0.271121632510072 3.134535209004686e-10 9.503826847538033 3.2473061318822274 DPVQEAWAEDVDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPVQEAWAEDVDLR 14 0 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 70723800.0 24930000.0 8153800.0 37640000.0 False True 24138610.795992095 11409654.861505276 27780954.824204408 1.0 0.47267239021889784 1.1508928603636577 24.524839313982856 -6.699166716094325 1.8336174139246826 0.6722882593930269 1.1488590088946957 0.41371926263392167 0.22262516302117197 0.39726191319826454 2.596069986896683 0.09687746880787575 0.24942057999064016 1.999094314004125e-07 6.699166716094325 0.4765707495016688 DPVQEAWAEDVDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DPVQEAWAEDVDLR 14 0 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 64985200.0 7707200.0 28130000.0 29148000.0 False True 10556760.119248537 26887123.58652957 22263842.721903503 1.0 2.546910537211627 2.1089654847142922 23.331663802215466 -10.566898232009809 5.4974812636650485 0.9944765688203977 2.327938010962961 0.9245795384179529 0.1787903189991479 0.012094572952352355 0.0009528324047916698 0.17298231893084837 0.05770432732890035 2.710826784039261e-11 10.566898232009809 1.3334614421425632 DPVQEAWAEDVDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPVQEAWAEDVDLR 14 0 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 40998800.0 24930000.0 5921800.0 10147000.0 False True 20730399.58625942 5889898.088014737 12268690.785572896 1.0 0.2841188884713392 0.5918212398426156 24.305244589417132 -10.494204828874478 6.231625213897417 1.0003961261444305 0.43797006415800344 0.8164571764786295 0.12561895891903455 0.0006918050126583215 5.615103409636243e-05 0.12171180636012022 0.04054334465511118 3.204757489291231e-11 10.494204828874478 -0.5624260619864271 DPVQLNLLYVQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DPVQLNLLYVQAR 13 0 Q9Y490;Q9Y4G6 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 13184700.0 3761100.0 4935800.0 4487800.0 False True 4930838.522544207 4199397.879597714 4023445.506017364 1.0 0.8516599885390111 0.8159759212600116 22.233401576870317 -13.999999999998623 0.2001362875481109 1.8250291874659255 0.7928321539521728 0.9994869309045703 0.001804869762335984 12.533588267998601 0.1418518782503395 4.04807515188805 0.022698654237750943 1.00000000000317e-14 13.999999999998623 -1.0321970335137527 DPVQLNLLYVQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DPVQLNLLYVQAR 13 0 Q9Y490;Q9Y4G6 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 16903300.0 6580000.0 3724600.0 6598700.0 False True 6371121.501709905 5211852.203532407 4870302.513243291 1.0 0.8180431344989466 0.7644340971893536 22.603115920226596 -13.999999999995266 0.17130460979797044 1.920789629416227 0.7177956320172969 0.9995112468022936 0.0022287933376793417 12.104453361555422 0.13109027212040106 3.7041850749034895 0.04319296820370281 1.0000000000109005e-14 13.999999999995266 -1.20299399739893 DPVQLNLLYVQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DPVQLNLLYVQAR 13 0 Q9Y490;Q9Y4G6 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 28034800.0 3761100.0 6291700.0 17982000.0 False True 5151680.309905754 6013711.890130401 13735021.950914942 1.0 1.1673301774116525 2.666124667034359 22.29661163839321 -6.9280562727605695 0.7625758428528067 0.9754894247388534 2.959125823525894 0.9961423295757597 0.04652670389808264 0.09365954196834353 0.0827164256791994 0.041908090158464896 0.13709287599434572 1.180167708086744e-07 6.9280562727605695 1.9836363987870405 up DPVQLNLLYVQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DPVQLNLLYVQAR 13 0 Q9Y490;Q9Y4G6 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 11532200.0 6580000.0 2458100.0 2494100.0 False True 5471561.543425068 2444857.727405351 3015604.7785845436 1.0 0.44682997860879914 0.5511415259887301 22.383521195660872 -10.170472082733301 5.762303904231033 1.000008314915711 0.49898575229894854 0.9685129954596178 0.04258501089356073 4.549034653106932e-06 6.549234904749734e-07 0.04123344283619809 0.013744253165725896 6.753484652702309e-11 10.170472082733301 -0.5010225626167626 DQALK(ub)ALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQALKALR 8 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 749910000.0 143190000.0 209710000.0 397010000.0 True False 187723476.6539323 178422085.44317737 355931213.5888311 1.0 0.9504516356901805 1.8960399622525066 27.48403384365368 -6.894536098783762 0.995130269533364 0.954578386616398 1.9849918756858889 0.9836474084681706 0.0555686771706792 0.11554103307754426 0.20095133837702575 0.042272400084936476 0.10726416039336077 1.2748641281685564e-07 6.894536098783762 1.030413489069491 DQALK(ub)ALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQALKALR 8 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 1170040000.0 237550000.0 236410000.0 696080000.0 True False 230009105.27829605 330809745.8618632 513755766.0476135 1.0 1.4382463053434555 2.23363229653888 27.77711573278956 -6.961898467471307 0.40779690950879305 0.9598647333694149 2.741425808260316 0.9998342574589715 0.006573705357878737 0.07902980009444467 0.018675962482867455 0.010236821808188265 0.06645691346578896 1.091695531153439e-07 6.961898467471307 1.781561074890901 up DQALK(ub)ALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DQALKALR 8 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 1548370000.0 341150000.0 694470000.0 512750000.0 True False 517549491.4057685 570536402.5811247 411404737.7536909 1.0 1.1023803753172148 0.7949089789195481 28.947121588071536 -6.816928671569925 1.3850117945168847 1.055359851014792 0.7886231848767036 0.8771980579293706 0.04479836846402851 0.19750031697103426 0.7452305943939649 0.02542232755194176 0.05865055872747354 1.5243030844425372e-07 6.816928671569925 -0.26673666613808833 DQALK(ub)ALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQALKALR 8 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 856070000.0 143190000.0 164290000.0 548590000.0 True False 196131212.5642511 157031124.56562173 419024340.56570125 1.0 0.8006432148793223 2.1364490388210498 27.547243905176572 -6.868920820192236 1.13985447294343 0.8879646754029895 2.213070799220845 0.9635908091687966 0.11226843452499807 0.1378903547147949 0.335525455668397 0.07649073487672599 0.18075487654065578 1.352319093163916e-07 6.868920820192236 1.3251061238178556 up DQALK(ub)ALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DQALKALR 8 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 1055030000.0 237550000.0 388370000.0 429110000.0 True False 197533350.2493351 386277773.724591 518834917.0195313 1.0 1.955506618183788 2.6265687103703526 27.557521008223837 -7.909438339554695 0.15236361432081252 3.5254240852766484e-19 3.9626807191768063 0.9999534476574581 0.004553753554869248 0.12037976330368554 0.024042501253755198 0.24451961663125274 0.3180682843425789 1.2318608709839107e-08 7.909438339554695 3.9626807191768063 DQALK(ub)ALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DQALKALR 8 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 1276280000.0 341150000.0 662170000.0 272960000.0 True False 441625400.0718566 625319657.4057888 223284080.80611497 1.0 1.4159503898644492 0.505596101967379 28.718247910163985 -6.782488697185974 1.5262551290837372 1.2347647056132216 0.4978258871251368 0.7760511313538951 0.1760946497942549 0.24673834600291406 1.135422677883316 0.09086011696466549 0.21394282236795387 1.650103945856949e-07 6.782488697185974 -0.7369388184880847 DQATSMSQLHLICGGPLEPAPSGDPEAPPPGPLHSAFSSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DQATSMSQLHLICGGPLEPAPSGDPEAPPPGPLHSAFSSSR 41 0 A8MVW0 A8MVW0 FAM171A2 Protein FAM171A2 0 271857000.0 117510000.0 78126000.0 76221000.0 False True 178271261.13173625 64183804.89877598 61155885.94114896 1.0 0.3600345029889388 0.34304960627364883 27.40949890589515 DQDLEPGAPSMGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQDLEPGAPSMGAK 14 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 7242000.0 1973000.0 0.0 5269000.0 False True 1910368.1949656003 0.0 3888890.833388231 1.0 0.0 2.0356760773324423 20.86541929232755 -6.773125798271441 1.5624405605319847 0.42872132337112223 2.048517476851104 0.7423903502406557 0.42182891096807984 0.2614044161600804 1.2598035787907842 0.2127494593485493 0.5050039201859176 1.686064567121272e-07 6.773125798271441 1.6197961534799816 DQDLIK(ub)DPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DQDLIKDPR 9 1 E9PPJ1;Q8NG31-3;Q8NG31-4;Q8NG31-2;Q8NG31;H0YCZ2 E9PPJ1 CASC5 Protein CASC5 1 3594000.0 0.0 1934000.0 1660000.0 True False 0.0 1923581.1581310544 2007098.3250271988 0.0 DQDTLIQHGIHDGLTVHLVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DQDTLIQHGIHDGLTVHLVIK 21 0 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 0 26626300.0 4800200.0 12142000.0 9684100.0 False True 7282254.341626752 9975165.234120997 7770033.390308191 1.0 1.369790832091795 1.0669818748149458 22.79595369887283 -10.167091053474152 5.693175899075829 0.9999960433434308 1.218386353453382 0.4095101833321837 0.12362123914545964 6.208492497785026e-06 9.084124778250843e-07 0.11969791868901067 0.03989858337065152 6.806266446592399e-11 10.167091053474152 0.21839031010995125 DQDTLSQHGIHDGLTVHLVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DQDTLSQHGIHDGLTVHLVIK 21 0 Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UMX0-2 UBQLN1 Ubiquilin-1 0 99183200.0 25149200.0 41919000.0 32115000.0 False True 38153175.05279772 34438226.9353581 25767456.173495483 1.0 0.9026306955502722 0.6753685935138442 25.18529978529031 -6.956916599523326 0.4769091366299328 1.0056168010883566 0.5629567118759514 0.9996381857141841 0.0025872977505513725 0.0808215584461731 0.02534512533902415 0.0031845134997563695 0.018749554173268786 1.1042906638699889e-07 6.956916599523326 -0.4426600892124052 DQFALAFHLISQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DQFALAFHLISQK 13 0 P42566;B1AUU8 P42566 EPS15 Epidermal growth factor receptor substrate 15 0 23461300.0 6895500.0 7858300.0 8707500.0 False True 10460977.628575336 6455924.967821858 6986458.808367167 1.0 0.6171435593349108 0.6678590717260373 23.318514348873844 -10.053801937678394 4.973176654675679 1.0000070414862225 0.6425013155282489 0.9851307888295415 0.020704521242594646 1.6164884056315646e-06 3.07555944525458e-07 0.020047461271365 0.006682355495705647 8.834827255792355e-11 10.053801937678394 -0.3575057259579737 DQFGFINYEVGDSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQFGFINYEVGDSK 14 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 5591100.0 1038800.0 2381300.0 2171000.0 False True 1361876.8597535093 2026019.3222347002 1946365.745702504 1.0 1.4876670439950028 1.429178953855478 20.377164830784004 -10.51951539044378 6.109307679004269 0.9994680900977491 1.4584229989252402 0.9879387205295102 0.023877662811957426 0.00017318204126336205 1.3620436003862744e-05 0.023144971264205613 0.007706482534755588 3.0233234286624895e-11 10.51951539044378 0.4589549088274911 DQFGFINYEVGDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQFGFINYEVGDSK 14 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 4840500.0 1038800.0 1397900.0 2403800.0 False True 1422872.4325144505 1336136.1557628757 1836071.9478150026 1.0 0.9390414243964953 1.2903981452296187 20.440374892306895 -6.862150695537442 1.174714624060568 0.9667144615937888 1.3081335416252715 0.9562077507547613 0.03207975835822387 0.14460872599701946 0.3779589516690873 0.021278821047766107 0.049801208485234505 1.373565279860895e-07 6.862150695537442 0.3414190800314827 DQFGFINYEVGDSK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQFGFINYEVGDSKK 15 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 7725700.0 2457000.0 3472800.0 1795900.0 True False 3221150.7936218455 2954671.776868373 1610077.4954892371 1.0 0.917272107446468 0.4998454275029062 21.619144769355124 -6.939602054033651 0.6632548360829638 1.0047190361610894 0.38858419852971643 0.9981113181332986 0.009513041007216836 0.08794863180241447 0.05543981433792462 0.009232549093532827 0.03599052633243752 1.1492061619195583e-07 6.939602054033651 -0.6161348376313729 down DQFGFINYEVGDSK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQFGFINYEVGDSKK 15 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 8702700.0 2457000.0 2014700.0 4231000.0 True False 3365419.297928384 1925683.8922780347 3231724.9401802486 1.0 0.5721973168286661 0.9602740859570063 21.682354830878015 -10.373859805092836 8.483748603186967 1.0000011396255588 0.7662357013928363 0.3260516629674104 0.1584316775653841 3.4150833301776724e-06 2.520623691608803e-07 0.15340156072312566 0.05113360406020301 4.228050782430887e-11 10.373859805092836 -0.23376543823272256 DQGTYEDYVEGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQGTYEDYVEGLR 13 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180;H0YI43 P60660-2 MYL6 Myosin light polypeptide 6 0 32612000.0 9945600.0 3102400.0 19564000.0 False True 9629882.371946208 4341204.4988022735 14439601.492580645 1.0 0.450805558274427 1.4994577228322248 23.19908674512434 -6.764412247782016 1.5959376589346612 0.6827456435859686 1.5041349253217053 0.7086619969666768 0.23116238525168373 0.27558160370522755 1.3843156171304374 0.11423351918988174 0.27333034141665885 1.7202348915383405e-07 6.764412247782016 0.8213892817357368 DQIGK(ub)GTQGATAGASSELDASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQIGKGTQGATAGASSELDASK 22 1 O76094;O76094-2 O76094 SRP72 Signal recognition particle subunit SRP72 1 8642900.0 2956600.0 3171200.0 2515100.0 True False 2862744.3513610177 4437476.697589527 1856319.8586173356 1.0 1.5500778808557751 0.6484406676882609 21.448967409940348 -6.741612079162904 1.6809698408382554 1.3266897763114032 0.6477450457420141 0.6120520536278322 0.2311126873591611 0.31492351937660196 1.7478962369102482 0.10874316804640431 0.26635708250895473 1.812958741949609e-07 6.741612079162904 -0.6789447305693891 DQILLEK(ub)EAELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQILLEKEAELR 12 1 Q15019;Q15019-2;Q15019-3;B5MCX3;H7C2Y0 Q15019 SEPT2 Septin-2 1 3564300.0 1389100.0 2175200.0 0.0 True False 1345003.7808548964 3043768.7035181453 0.0 1.0 2.263018696931468 0.0 20.35917879758038 -6.758212972726478 1.6386066296934625 1.7378448641643078 4.5801920334325015e-10 0.6710865210630164 0.531042051458439 0.28872661105690894 1.5307642462714366 0.2566108304968247 0.6130516422061695 1.7449662328752786e-07 6.758212972726478 -1.7378448637062887 DQILLEK(ub)EAELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DQILLEKEAELR 12 1 Q15019;Q15019-2;Q15019-3;B5MCX3;H7C2Y0 Q15019 SEPT2 Septin-2 1 5367300.0 1389100.0 2770800.0 1207400.0 True False 1155098.1975640962 2755873.1504392633 1459861.7576131548 1.0 2.38583451714402 1.2638421224202 20.139584073014657 -6.593737784812388 2.2146526507820883 1.935770619279137 1.2672609511955404 0.0029020064423325165 0.5999618728894468 0.6587217221959167 6.096449418470356 0.2256739651101928 0.6681417942662773 2.548368423678504e-07 6.593737784812388 -0.6685096680835967 DQITAGNAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQITAGNAAR 10 0 P22234;E9PBS1;P22234-2 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 13614690.0 546890.0 6717500.0 6350300.0 False True 716978.0860902935 5715275.18460991 5693231.872378912 1.0 7.971338727764337 7.940593977459344 19.451569499121312 -10.005673828612075 5.012815719530021 0.9999283266361094 7.955966352686301 0.999985348502846 0.012551492005994171 2163831.750976734 0.27374456220392146 1800.9629469787349 0.004296709525301732 9.870204966163466e-11 10.005673828612075 6.956038026050191 DQITAGNAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQITAGNAAR 10 0 P22234;E9PBS1;P22234-2 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 6741200.0 1970600.0 1056900.0 3713700.0 False True 1908044.3816519063 1478925.681660689 2740970.5613880977 1.0 0.7751002523223783 1.4365339652189213 20.863663298552524 -6.814941967544946 1.3934858534133492 0.8781243794017888 1.4494807656234197 0.8723778029829734 0.09809805890460414 0.2001387116914558 0.7649324008899601 0.05533683267958313 0.12775399521860945 1.5312920664024028e-07 6.814941967544946 0.5713563862216309 DQITAGNAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQITAGNAAR 10 0 P22234;E9PBS1;P22234-2 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 13335190.0 546890.0 6162900.0 6625400.0 False True 749090.0121465422 5890602.70001503 5060616.974396171 1.0 7.863678068721425 6.755686088905131 19.514779560644204 -10.448802377457246 6.646219660311497 0.9986302951269636 7.309682078813278 0.9773957557630838 0.45233583160767304 0.00917839213335444 0.0007612021549870813 0.43787364229708126 0.14599076189245008 3.557931828366394e-11 10.448802377457246 6.311051783686315 DQIYDIFQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQIYDIFQK 9 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 28288200.0 2034200.0 12307000.0 13947000.0 False True 2666855.899220823 10470843.57231026 12503898.22907088 1.0 3.926287721571133 4.688629120427599 21.346708441796043 -9.541823643244458 0.39276866781208913 5.476840383896023e-25 4.79993648298023 0.9983673865007793 0.0642412651456372 0.8810527130552536 0.16301337222628184 1.4116314384422688 0.19634030051967274 2.8719465750981464e-10 9.541823643244458 4.79993648298023 DQIYDIFQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQIYDIFQK 9 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 18932100.0 5678700.0 2889400.0 10364000.0 False True 5498432.776863225 4043152.4880219437 7649357.486664565 1.0 0.7353281656975177 1.391188689048302 22.390589033916424 -6.797156279723481 1.467567725784978 0.8534470462236167 1.399615482730011 0.823750134082232 0.11310378347727813 0.22480954000425557 0.9561794652500769 0.06064043580446846 0.1412740900602283 1.5953049776490291e-07 6.797156279723481 0.5461684365063942 DQIYDIFQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQIYDIFQK 9 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 23652200.0 2034200.0 10781000.0 10837000.0 False True 2786298.7121880027 10304659.772000547 8277523.795020876 1.0 3.69833274764305 2.9707955427796784 21.409918503318934 -10.113645378507002 5.641819473072339 0.9999766894498519 3.334564145211685 0.932106879690427 0.297015820135462 8.708778325904908e-05 1.3683113727044911e-05 0.2875871754209342 0.09586144374523363 7.697587272745609e-11 10.113645378507002 2.3345874557618336 DQK(ub)AVDPEDDFQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQKAVDPEDDFQR 13 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 5282750.0 920250.0 1753500.0 2609000.0 True False 1206456.6617136756 1491884.6350894647 2339045.7072951808 1.0 1.236583693748569 1.938773087773209 20.20234466137702 -6.951691440458609 0.5399577987818113 0.9896590861265916 2.2181223347725125 0.9993274075303675 0.01033888771882309 0.08281362230046399 0.03320620745585629 0.011372259280247776 0.05815080049847537 1.117657043875317e-07 6.951691440458609 1.2284632486459208 DQK(ub)LPHLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQKLPHLER 9 1 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 6180820.0 875350.0 896870.0 4408600.0 True False 847562.4933923654 1254994.8681152624 3253855.40483495 1.0 1.4807107179697754 3.8390743221911663 19.692960220955204 -6.94022947152256 0.6574243569847417 0.9736289325905712 4.479368081772739 0.9981938135472304 0.05272744484562759 0.08766208440884254 0.054133915245046266 0.05141591017795321 0.20277525824993958 1.1475471229632049e-07 6.94022947152256 3.5057391491821677 up DQK(ub)LPHLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DQKLPHLER 9 1 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 17947100.0 2603400.0 3473700.0 11870000.0 True False 3370152.6206861204 3280385.541372289 9709781.796485133 1.0 0.9733640907646621 2.8811104093286866 21.684382496078868 -6.903734452890624 0.9373528280129864 0.9286036387930072 3.0972705246111425 0.988334512609074 0.09646184563540959 0.10870851628157861 0.1623207051984746 0.07660556686307235 0.20332223513145148 1.2481464536496165e-07 6.903734452890624 2.1686668858181353 up DQK(ub)LSELDDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQKLSELDDR 10 1 K7ENK9;K7EKX0;J3QRU4;F8WCA0;L7N2F9;Q15836;P63027;F5GZV7;P23763-2;P23763-3;P23763 K7ENK9 VAMP2;VAMP3;VAMP1 Vesicle-associated membrane protein 3;Vesicle-associated membrane protein 2;Vesicle-associated membrane protein 1 1 21369400.0 10253200.0 8569000.0 2547200.0 True False 13442044.492130041 7290538.601700382 2283640.178467721 1.0 0.5423682837807 0.16988786042217996 23.68024924833528 -7.946976712096664 0.34812474183062325 1.085036934201824 6.448279278757549e-12 0.9986187163507022 0.012617195251237048 0.10295131374859734 0.06770066815076381 0.04771809050330624 0.08473145787710944 1.1298564986419191e-08 7.946976712096664 -1.0850369341953758 down DQK(ub)LSELDDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQKLSELDDR 10 1 K7ENK9;K7EKX0;J3QRU4;F8WCA0;L7N2F9;Q15836;P63027;F5GZV7;P23763-2;P23763-3;P23763 K7ENK9 VAMP2;VAMP3;VAMP1 Vesicle-associated membrane protein 3;Vesicle-associated membrane protein 2;Vesicle-associated membrane protein 1 1 21554600.0 6565100.0 7103600.0 7885900.0 True False 6356694.494054056 9940104.52478462 5820346.218071022 1.0 1.5637222355238916 0.9156246573616642 22.599845322769667 -6.676748102190458 1.9132766874101916 1.3577066342674704 0.9181409340368797 0.30936434587292394 0.23909014912115875 0.44579599552554305 3.1521611899137363 0.10037315470079906 0.26585146365507245 2.104999019162726e-07 6.676748102190458 -0.4395657002305907 DQK(ub)LSELDDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQKLSELDDR 10 1 K7ENK9;K7EKX0;J3QRU4;F8WCA0;L7N2F9;Q15836;P63027;F5GZV7;P23763-2;P23763-3;P23763 K7ENK9 VAMP2;VAMP3;VAMP1 Vesicle-associated membrane protein 3;Vesicle-associated membrane protein 2;Vesicle-associated membrane protein 1 1 22417600.0 10253200.0 6631500.0 5532900.0 True False 14044085.122311482 6338498.402562057 4226142.973652395 1.0 0.45132868017812316 0.30091977774603695 23.74345930985817 -13.999999999999998 0.18159518222980062 3.860894600199959 0.18338936692383093 0.9994963011463445 0.006742837080189806 12.225778696105127 0.13510247867903205 12.345817481215164 0.11079647269163057 1.0000000000000041e-14 13.999999999999998 -3.677505233276128 DQK(ub)LSELDDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DQKLSELDDR 10 1 K7ENK9;K7EKX0;J3QRU4;F8WCA0;L7N2F9;Q15836;P63027;F5GZV7;P23763-2;P23763-3;P23763 K7ENK9 VAMP2;VAMP3;VAMP1 Vesicle-associated membrane protein 3;Vesicle-associated membrane protein 2;Vesicle-associated membrane protein 1 1 23378500.0 6565100.0 12317100.0 4496300.0 True False 5459171.533243147 12250745.337547064 5436455.541457708 1.0 2.2440667531597467 0.9958389305690228 22.380250598203943 -6.646968296579104 2.0195831311547017 1.8092198036326388 1.001102573826864 0.18175236900752034 0.5313825809895538 0.5160079979940303 4.030663380465459 0.21365716978769828 0.5884234216146167 2.2544037772255032e-07 6.646968296579104 -0.8081172298057748 DQK(ub)LSELDDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DQKLSELDDR 10 1 K7ENK9;K7EKX0;J3QRU4;F8WCA0;L7N2F9;Q15836;P63027;F5GZV7;P23763-2;P23763-3;P23763 K7ENK9 VAMP2;VAMP3;VAMP1 Vesicle-associated membrane protein 3;Vesicle-associated membrane protein 2;Vesicle-associated membrane protein 1 1 36845600.0 17673700.0 11987200.0 7184700.0 True False 22878953.05071076 11320101.78240434 5877158.321247414 1.0 0.49478233367206764 0.2568805621577528 24.447517699583695 -10.09624774600655 0.1781995808592248 1.6894874879129242 2.28803455543016e-13 0.999560461435462 0.006496077369959849 1.661126180324097 0.08370603690081893 0.7025930209259371 0.16486969756675504 8.012208715330627e-11 10.09624774600655 -1.6894874879126955 DQLALAIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQLALAIGK 9 0 P43897;C9JT21;P43897-2 P43897 TSFM Elongation factor Ts, mitochondrial;Elongation factor Ts 0 12350300.0 3800100.0 4831500.0 3718700.0 False True 4981967.900220752 4110659.0330394967 3333924.596289228 1.0 0.8251074907281825 0.669198329467659 22.248284295370702 -6.972483644914546 0.18969949034014333 1.1060824193791567 0.38396551178200655 0.9999958295162154 0.00027588522607589424 0.0755046631369681 0.006049644139800063 0.005518399820873584 0.017009977966849367 1.065408985123451e-07 6.972483644914546 -0.7221169075971502 DQLALAIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQLALAIGK 9 0 P43897;C9JT21;P43897-2 P43897 TSFM Elongation factor Ts, mitochondrial;Elongation factor Ts 0 6430990.0 2095000.0 979490.0 3356500.0 False True 2028495.371745021 1370605.4649728718 2477331.9571583965 1.0 0.6756759143077576 1.2212657675562069 20.951978580190705 -6.74566431732614 1.665836433410506 0.8083058168854349 1.2220051548010746 0.6301323712457276 0.13626403321191669 0.30766739682378635 1.6783817996638997 0.06465587407422131 0.15769152178950585 1.79612138076518e-07 6.74566431732614 0.41369933791563973 DQLALAIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQLALAIGK 9 0 P43897;C9JT21;P43897-2 P43897 TSFM Elongation factor Ts, mitochondrial;Elongation factor Ts 0 9361000.0 3800100.0 2619500.0 2941400.0 False True 5205099.663841133 2503761.8284718874 2246701.9000345482 1.0 0.4810209198999702 0.43163475151916336 22.311494356893594 -13.999999999999998 0.33268706972939927 6.741793279469763 0.42316125650733005 0.9997203919149207 0.00429877807010761 19.052744192461155 0.18458989273999402 76.65172353990341 0.015668877299065836 1.0000000000000041e-14 13.999999999999998 -6.318632022962433 DQLALAIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DQLALAIGK 9 0 P43897;C9JT21;P43897-2 P43897 TSFM Elongation factor Ts, mitochondrial;Elongation factor Ts 0 4264940.0 2095000.0 1318400.0 851540.0 False True 1742085.3242363993 1311297.51751809 1029593.0769238927 1.0 0.7527171598743968 0.5910118537822996 20.73238385562498 -8.628318741837303 0.08994097205135207 1.6117587834305052 3.2823616021563804e-05 0.9999840122960405 0.0006724473727586735 0.21519586040349964 0.023543880071262138 0.2176510088619419 0.18845712423349997 2.3533214762194768e-09 8.628318741837303 -1.6117259598144835 DQLIYNLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQLIYNLLK 9 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8;F5H8H6;F5GXC7;F5GWW2;F5GZQ4;F5GXU1 P00338 LDHA L-lactate dehydrogenase A chain 0 110888000.0 25157000.0 41939000.0 43792000.0 False True 32981070.62073455 35681864.676941626 39260823.922526054 1.0 1.0818892172199268 1.190404774120448 24.97513489604193 -6.967234890439882 0.31736298899882026 0.9846713690667701 1.2911092087379663 0.9999520748255494 0.0005398462649610947 0.0772105546183367 0.012227382202078276 0.0016628265899399951 0.009567845723966661 1.0783633260378871e-07 6.967234890439882 0.3064378396711962 DQLIYNLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQLIYNLLK 9 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8;F5H8H6;F5GXC7;F5GWW2;F5GZQ4;F5GXU1 P00338 LDHA L-lactate dehydrogenase A chain 0 118163000.0 43725000.0 20819000.0 53619000.0 False True 42336973.8088549 29132135.26965078 39574575.36447966 1.0 0.6881015020388092 0.9347521044643612 25.335414815300368 -9.88001112079125 5.944951798565231 1.0000000414191563 0.8114268043102714 0.43799801962618323 0.10069468678262623 5.528953197321173e-08 1.0263924626589942e-08 0.09749723303224248 0.0324990704133153 1.3182229829575691e-10 9.88001112079125 -0.18857323710888496 DQLIYNLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DQLIYNLLK 9 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8;F5H8H6;F5GXC7;F5GWW2;F5GZQ4;F5GXU1 P00338 LDHA L-lactate dehydrogenase A chain 0 183162000.0 12590000.0 159080000.0 11492000.0 False True 19099950.452289667 130690931.10228685 9220601.16287746 1.0 6.842474875981673 0.48275523991069363 24.187065559942262 -6.665134325220966 1.9545495508193436 4.744667173237805 0.5088827471541333 0.2577302877798824 2.4845627658169254 0.47237254606664736 3.474185424760122 1.0250742082179778 2.756308712252727 2.1620497085935012e-07 6.665134325220966 -4.235784426083672 DQLIYNLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQLIYNLLK 9 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8;F5H8H6;F5GXC7;F5GWW2;F5GZQ4;F5GXU1 P00338 LDHA L-lactate dehydrogenase A chain 0 246977000.0 25157000.0 101420000.0 120400000.0 False True 34458222.74236239 96938929.04890954 91963999.71583585 1.0 2.8132306698956464 2.668854990097234 25.03834495756482 -10.497469996966775 5.897112577851289 0.9981062029051124 2.7410428299964402 0.9948690666946808 0.058941124462261206 0.0014681691018373726 0.0001251120630216054 0.05709355080800723 0.019023166120756187 3.180753421616948e-11 10.497469996966775 1.7429366270913278 DQLIYNLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DQLIYNLLK 9 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8;F5H8H6;F5GXC7;F5GWW2;F5GZQ4;F5GXU1 P00338 LDHA L-lactate dehydrogenase A chain 0 76830000.0 43725000.0 18974000.0 14131000.0 False True 36359274.84593629 18871783.295955896 17085726.76563818 1.0 0.5190362947534172 0.4699138483381434 25.115820090734644 -13.999999999999998 0.32241673228464446 6.0029666975391605 0.46042241096318254 0.9996988920280955 0.004149821087853207 18.20288600806568 0.18119454552539235 61.50885692520486 0.016201684942596255 1.0000000000000041e-14 13.999999999999998 -5.5425442865759775 DQLIYNLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DQLIYNLLK 9 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8;F5H8H6;F5GXC7;F5GWW2;F5GZQ4;F5GXU1 P00338 LDHA L-lactate dehydrogenase A chain 0 38067000.0 12590000.0 12595000.0 12882000.0 False True 16298003.186002256 11894077.178105174 10537608.180482008 1.0 0.7297873882071977 0.6465582353998043 23.95819188203471 -13.999999997577826 0.16492597498438583 2.3455453497467826 0.5690294018472957 0.9995242856789461 0.0032906597888412003 12.046188805014923 0.12848654388100106 5.18416709779686 0.0711235857857036 1.0000000055772628e-14 13.999999997577826 -1.776515947899487 DQLIYNLLK(ub)EEQTPQNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQLIYNLLKEEQTPQNK 17 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8;F5H8H6;F5GXC7;F5GWW2;F5GZQ4;F5GXU1 P00338 LDHA L-lactate dehydrogenase A chain 1 87774000.0 31125300.0 38126700.0 18522000.0 True False 40805569.71783396 32438344.9767126 16605521.115569705 1.0 0.7949489542976657 0.40694251374003754 25.282262749150483 -6.9611136894909 0.41944712331733497 1.0172530010571255 0.17001525128925457 0.9998092899355131 0.0033961661047245757 0.07930572040072781 0.0196792663801431 0.005017455839625507 0.03230352142868216 1.0936700281535993e-07 6.9611136894909 -0.8472377497678709 down DQLIYNLLK(ub)EEQTPQNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQLIYNLLKEEQTPQNK 17 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8;F5H8H6;F5GXC7;F5GWW2;F5GZQ4;F5GXU1 P00338 LDHA L-lactate dehydrogenase A chain 1 118225700.0 40923200.0 41577800.0 35724700.0 True False 39624115.41622713 58180032.365362585 26367329.351972766 1.0 1.4682985791409318 0.6654364160562343 25.239875392552104 -6.74865421332497 1.6554516082147395 1.2758187287245204 0.664062889659492 0.6429082656683551 0.19676796423444606 0.3023950656434167 1.6301952133050137 0.09392399578239607 0.22828925608589878 1.7837984683137005e-07 6.74865421332497 -0.6117558390650284 DQLIYNLLK(ub)EEQTPQNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DQLIYNLLKEEQTPQNK 17 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8;F5H8H6;F5GXC7;F5GWW2;F5GZQ4;F5GXU1 P00338 LDHA L-lactate dehydrogenase A chain 1 190626000.0 79599900.0 40762000.0 70264100.0 True False 120758867.83218528 33487702.625040334 56376369.837151006 1.0 0.2773105050270686 0.46685076507586537 26.847553895222163 -10.911138594534469 11.41704048032982 1.0607252921946226 0.372080635051475 0.9360341534767755 0.07737948713899731 0.03698027364665002 0.0002878253091634908 0.023164904405901923 0.02497412208561729 1.227047586238767e-11 10.911138594534469 -0.6886446571431477 DQLIYNLLK(ub)EEQTPQNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQLIYNLLKEEQTPQNK 17 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8;F5H8H6;F5GXC7;F5GWW2;F5GZQ4;F5GXU1 P00338 LDHA L-lactate dehydrogenase A chain 1 108117400.0 31125300.0 37150100.0 39842000.0 True False 42633164.53960535 35508685.743047714 30432140.17174693 1.0 0.8328888114805755 0.713813776208803 25.345472810673375 -6.974784512868909 0.08646595077370772 1.3713791268306408 0.17232576071888348 0.9999998588943486 4.371392952303398e-05 0.07477848726750101 0.002517126237566898 0.012983451396917764 0.021755831445034117 1.0597794334071763e-07 6.974784512868909 -1.1990533661117573 DQLIYNLLK(ub)EEQTPQNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DQLIYNLLKEEQTPQNK 17 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8;F5H8H6;F5GXC7;F5GWW2;F5GZQ4;F5GXU1 P00338 LDHA L-lactate dehydrogenase A chain 1 117311200.0 40923200.0 55426000.0 20962000.0 True False 34029454.00515084 55127409.13680033 25345057.28266271 1.0 1.619990997459319 0.7447976473212404 25.02028066798638 -6.7164262947223605 1.7723808771406142 1.3786278682078494 0.7464453809682753 0.4955426006767134 0.26101471236641566 0.3622898136838382 2.2222094066817806 0.11702829039924353 0.2950039375076407 1.921204986920734e-07 6.7164262947223605 -0.6321824872395742 DQLIYNLLK(ub)EEQTPQNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DQLIYNLLKEEQTPQNK 17 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8;F5H8H6;F5GXC7;F5GWW2;F5GZQ4;F5GXU1 P00338 LDHA L-lactate dehydrogenase A chain 1 223460600.0 79599900.0 70349400.0 73511300.0 True False 103043639.69860694 66434394.04790735 60132997.68963412 1.0 0.6447209574722106 0.583568261617287 26.618680217314612 -13.999999999999998 0.24753584293368594 3.4404438664688426 0.5583968737180223 0.9995381182475163 0.003945807545595068 13.901643890010002 0.1574404553723172 16.844633346477423 0.028613553081207353 1.0000000000000041e-14 13.999999999999998 -2.88204699275082 DQMQPGGTAISVTVPYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQMQPGGTAISVTVPYR 17 0 A0A3B3IRP5;Q6P1J9;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 0 9364500.0 3046300.0 3271200.0 3047000.0 False True 3993728.8004111634 2783149.711037729 2731725.668887859 1.0 0.6968799961457567 0.6840037983066406 21.929304937262277 DQMQPGGTAISVTVPYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQMQPGGTAISVTVPYR 17 0 A0A3B3IRP5;Q6P1J9;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 0 9379000.0 3046300.0 2545600.0 3787100.0 False True 4172599.433162083 2433126.9748265063 2892664.9777727714 1.0 0.5831201901359201 0.6932524974199715 21.99251499878517 -10.128434038580664 7.577376190926811 1.0000000900122858 0.6381863437779498 0.9350253117559588 0.04496132617355485 6.840282389431726e-08 7.790541166031387e-09 0.04353362790121201 0.0145112056244648 7.439880525571872e-11 10.128434038580664 -0.36181374623433604 DQNIFVQK(ub)LLGQFSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQNIFVQKLLGQFSEK 16 1 P53004 P53004 BLVRA Biliverdin reductase A 1 7220800.0 2280700.0 1354300.0 3585800.0 True False 2208300.4268920617 1895079.0525811987 2646571.408305848 1.0 0.8581617924370519 1.1984652885434632 21.074505025363948 -6.7935189735194 1.4824482682350764 0.921087789720949 1.202433180696083 0.8124639884557053 0.0604405160290008 0.23014610792679666 0.9991004371126194 0.03208657633886504 0.07492792607893417 1.608722094272736e-07 6.7935189735194 0.2813453909751341 DQNIFVQK(ub)LLGQFSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DQNIFVQKLLGQFSEK 16 1 P53004 P53004 BLVRA Biliverdin reductase A 1 7204700.0 2280700.0 2246100.0 2677900.0 True False 1896503.1021412674 2233999.8134840587 3237836.508789361 1.0 1.1779573737378741 1.7072666557379457 20.854910300798224 -6.95164351061032 0.5404999899271181 0.9922327284830157 1.9174557537282126 0.9993240253417855 0.007809779398957131 0.08283243926250966 0.033282547910399446 0.00858398393038808 0.04383780790322652 1.1177803981680993e-07 6.95164351061032 0.925223025245197 DQSAVVVQGLPEGVAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQSAVVVQGLPEGVAFK 17 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;P78347-5 A0A494C1K3 GTF2I General transcription factor II-I 0 16653200.0 3492700.0 5799900.0 7360600.0 False True 4578963.523354912 4934577.527833132 6598995.719860839 1.0 1.077662554563804 1.4411549002744382 22.126589641676848 -6.941289223668958 0.6474623975212707 0.9959933845202881 1.5430089383177934 0.9983278915047314 0.007862971936504917 0.08718343934417067 0.05196875700385532 0.007730941240288845 0.03111166300254002 1.1447503271958075e-07 6.941289223668958 0.5470155537975053 DQSAVVVQGLPEGVAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQSAVVVQGLPEGVAFK 17 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;P78347-5 A0A494C1K3 GTF2I General transcription factor II-I 0 13064500.0 4739400.0 2172700.0 6152400.0 False True 4588950.341216404 3040270.4404808185 4540901.871956298 1.0 0.662519795251244 0.9895295294811647 22.129732764205006 -10.726296876590027 9.560913447694864 1.0004203739680884 0.8260246625370129 0.2739902934909829 0.13350116496440728 0.0011990392180958505 3.432504466528735e-05 0.1295632175445306 0.04308731571720319 1.878032585617778e-11 10.726296876590027 -0.17439571143107546 DQSAVVVQGLPEGVAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQSAVVVQGLPEGVAFK 17 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;P78347-5 A0A494C1K3 GTF2I General transcription factor II-I 0 15216400.0 3492700.0 5327600.0 6396100.0 False True 4784045.576668485 5092209.0159827545 4885472.9118144335 1.0 1.0644148209659967 1.021201164060937 22.18979970319974 -10.19399604728175 3.8548829717326623 0.9999680768331322 1.0428079925271494 0.566802812282764 0.017641901639322905 12394575.123702776 0.22123154959806107 3680.585816157078 0.006039292165909985 6.397406580366339e-11 10.19399604728175 0.04283991569401724 DQSAVVVQGLPEGVAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DQSAVVVQGLPEGVAFK 17 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;P78347-5 A0A494C1K3 GTF2I General transcription factor II-I 0 9077700.0 4739400.0 2434800.0 1903500.0 False True 3941021.0910195713 2421683.249130041 2301513.049210405 1.0 0.614481169524402 0.5839890211333496 21.910138039639282 -13.999999999999979 0.3596793445414908 6.034153348914959 0.5803006450505309 0.9997727085481489 0.002854399999923604 21.6621554746872 0.19379674596331492 83.69596569359771 0.008808142584886885 1.000000000000049e-14 13.999999999999979 -5.453852703864428 DQSAVVVQGLPEGVAFK(ub)HPENYDLATLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DQSAVVVQGLPEGVAFKHPENYDLATLK 28 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;P78347-5 A0A494C1K3 GTF2I General transcription factor II-I 1 68661000.0 16857000.0 15993000.0 35811000.0 True False 25573301.411774997 13138924.196120663 28732940.15348115 1.0 0.5137750493986265 1.1235522426623934 24.608135083021242 -6.694285902895459 1.8510063620762902 0.6964058097706208 1.1215717327076469 0.3906499158419282 0.20546281192444585 0.40751501532969797 2.7102190553070686 0.08868737532441615 0.22972352428360637 2.0216878315717167e-07 6.694285902895459 0.42516592293702604 DQSLK(ub)ILNPEEIEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQSLKILNPEEIEK 14 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 32444800.0 8121600.0 7854000.0 16469200.0 True False 10647496.24968627 6682213.814652218 14765125.167721644 1.0 0.627585458398176 1.3867227394568655 23.3440108859467 -6.773301104680078 1.5616690041523584 0.7872926284395824 1.39154973077774 0.7430561080640492 0.15710483673900758 0.26113710875373713 1.2572778160899112 0.07927196337274138 0.188146094841829 1.6853841111446335e-07 6.773301104680078 0.6042571023381577 DQSLK(ub)ILNPEEIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQSLKILNPEEIEK 14 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 42644000.0 2784100.0 12794000.0 27065900.0 True False 2695720.2694392917 17902710.919828586 19976528.83040471 1.0 6.641160480479802 7.410460594474002 21.36223936746461 -9.590183677518366 0.5641304955622054 4.7558563361048176e-23 7.353669204614546 0.9988105736392895 0.09856355549774072 0.8931973118454922 0.2532221283993239 2.032372501217573 0.1396243926099431 2.569308907125905e-10 9.590183677518366 7.353669204614546 DQSLK(ub)ILNPEEIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DQSLKILNPEEIEK 14 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 118221500.0 16163500.0 43355000.0 58703000.0 True False 24521211.210133772 35617961.51583889 47100326.31956103 1.0 1.4525367939867184 1.9207993404541162 24.547526906033735 -6.970696493793736 0.24097033903259119 0.8338705116105767 2.5530257089271493 0.9999873167989854 0.0013388159719603567 0.0760773447359579 0.008217256345545444 0.01111677897846626 0.045572319719788826 1.0698022481314214e-07 6.970696493793736 1.7191551973165726 DQSLK(ub)ILNPEEIEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQSLKILNPEEIEK 14 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 40024900.0 8121600.0 9127000.0 22776300.0 True False 11124374.997987442 8723738.961047115 17397007.032622837 1.0 0.7842003674476421 1.5638637708428746 23.407220947469593 -6.832869289590929 1.314936163201905 0.8848973843355636 1.5861162002401936 0.9115090041739148 0.09777950304901901 0.1772981034303557 0.598510455146862 0.05836512861972133 0.13432287206165883 1.469368449624951e-07 6.832869289590929 0.70121881590463 DQSLK(ub)ILNPEEIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DQSLKILNPEEIEK 14 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 43587800.0 2784100.0 21319500.0 19484200.0 True False 2315102.5065425113 21204647.6219106 23558256.13523794 1.0 9.159269432772838 10.17590196056632 21.142644642898887 -9.48724830668479 0.6243478734290325 4.4754476744448125e-20 10.058345105310394 0.99880135722742 0.14218893612494607 0.8137486914726177 0.28601617837812754 2.2410883520379303 0.17034876649841563 3.256504580044915e-10 9.48724830668479 10.058345105310394 DQSLK(ub)ILNPEEIEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DQSLKILNPEEIEK 14 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 151795500.0 16163500.0 60193000.0 75439000.0 True False 20923969.380218234 56843206.63610042 61709876.069506474 1.0 2.71665502865057 2.9492432792339924 24.318653228126184 -10.319025565637478 0.4279902414807833 2.5867044165909538e-12 2.961394820863742 0.9992576873858856 0.02368340862491791 1.698450403125913 0.1992033333373446 2.015298631561138 0.0550368637000155 4.797052089722242e-11 10.319025565637478 2.9613948208611554 DQTDDQVTIDSALATQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQTDDQVTIDSALATQK 17 0 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 10646700.0 1728300.0 4720700.0 4197700.0 False True 2265818.036881006 4016389.961144479 3763362.2711816686 1.0 1.772600401166022 1.6609287285761463 21.11160057530598 -10.105500206968781 4.396027393982549 0.9999171162899629 1.7167645649143317 0.9821203516628699 0.045589769593354465 10583900.406366058 1.4931122836970023 8975.368981942867 0.015606590724050526 7.843317450982033e-11 10.105500206968781 0.7168474486243688 DQTDDQVTIDSALATQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQTDDQVTIDSALATQK 17 0 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 7523200.0 2451500.0 0.0 5071700.0 False True 2373678.4743832573 0.0 3743269.6222613594 1.0 0.0 1.5769910131716374 21.178693097889678 -6.7353679303891925 1.7038062683478237 0.4018354849723948 1.5769866322847292 0.5839282837276969 0.42022728843980783 0.32625279102301696 1.8577686247401661 0.19527268035987094 0.48161176313417825 1.8392131763466798e-07 6.7353679303891925 1.1751511473123344 DQTDDQVTIDSALATQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQTDDQVTIDSALATQK 17 0 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 9687800.0 1728300.0 4318300.0 3641200.0 False True 2367299.2155513316 4127503.2272915207 2781223.5528679537 1.0 1.7435494424097322 1.1748508741934514 21.174810636828873 -10.201835689537544 4.579836119100045 0.9998984826814015 1.4592001583061216 0.46504545620995075 0.23217021827899495 163240012.15743253 32.508566859448074 174756.2284290185 0.07947804108037665 6.282960226284967e-11 10.201835689537544 0.45930167562472013 DQTDDQVTIDSALATQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DQTDDQVTIDSALATQK 17 0 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 3507600.0 2451500.0 0.0 1056100.0 False True 2038530.8698642182 0.0 1276925.6271453176 1.0 0.0 0.6263950406747437 20.959098373323954 -10.198997791496511 7.085168115136159 1.000001450763253 0.3131975203373719 0.6158128020175138 0.2557247045105061 5.860361086351396e-06 6.62395254428565e-07 0.24760490053826004 0.08253479348191689 6.32415067367648e-11 10.198997791496511 -0.6868039304258812 DQTIVDPFSSK(ub)HNVIVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DQTIVDPFSSKHNVIVGR 18 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 30823200.0 9117500.0 7396700.0 14309000.0 True False 11802783.482793922 6985067.142778137 11704908.822738485 1.0 0.5918152402745468 0.9917074933893248 23.492623798651806 -10.8339788221488 10.242648787496831 1.0041501554290966 0.791761367262338 0.2655460897497951 0.16325532870385054 0.01563089790887292 0.00025335778296373915 0.15969469173387701 0.052690430770802564 1.4656193083867717e-11 10.8339788221488 -0.21238878816675855 DQTK(ub)AQAAAPASVPAQAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQTKAQAAAPASVPAQAPK 19 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 25655300.0 7722000.0 7194300.0 10739000.0 True False 7476869.336809102 10067021.507778876 7926133.736905712 1.0 1.346422018934889 1.0600872343568788 22.83400289054585 -10.06976040464233 4.419196873936709 0.9999845966718679 1.2032546266605026 0.40185970149192407 0.1168956863636767 81125878.13012283 1.3353135958151212 12997.086201032675 0.04001650267645945 8.516077309894618e-11 10.06976040464233 0.20327002998863475 DQTK(ub)SIVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQTKSIVEK 9 1 O95197-3;O95197-4;O95197-7;O95197-2;O95197 O95197-3 RTN3 Reticulon-3 1 21313900.0 4111400.0 6310500.0 10892000.0 True False 5390085.214854234 5368997.998136341 9765000.323441595 1.0 0.99608777674613 1.8116597297071997 22.36187665085034 -6.905820262954646 0.9237339027630922 0.9712900957320801 1.9081514287717787 0.9892460978760702 0.03977406138128822 0.10724748521498384 0.15424268044413264 0.03190495480351004 0.08571840570483655 1.2421662839691247e-07 6.905820262954646 0.9368613330396985 DQTK(ub)SIVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQTKSIVEK 9 1 O95197-3;O95197-4;O95197-7;O95197-2;O95197 O95197-3 RTN3 Reticulon-3 1 16125800.0 2993200.0 3200500.0 9932100.0 True False 2898182.5043948432 4478476.340387008 7330585.053386839 1.0 1.5452706424097813 2.5293731648267976 21.466717016494723 -6.962002502418049 0.4062278529901318 0.9494820339629777 3.161459449143837 0.9998374087032725 0.008069850082786587 0.07899340121258289 0.018544230128043293 0.012662523078611685 0.08226838532962304 1.0914340475543706e-07 6.962002502418049 2.2119774151808596 DQTK(ub)SIVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DQTKSIVEK 9 1 O95197-3;O95197-4;O95197-7;O95197-2;O95197 O95197-3 RTN3 Reticulon-3 1 28635700.0 1918100.0 4240600.0 22477000.0 True False 2909897.9318933142 3483831.79804097 18034411.09798093 1.0 1.1972350507064788 6.197609510738718 21.472537119112765 -6.915215917684233 0.8594468057102965 0.8695297775523013 6.921487897735834 0.9927457694476544 0.20484118994787423 0.10106930913824994 0.1208014384206945 0.1721576143665405 0.4943049547765497 1.2155815011435604e-07 6.915215917684233 6.051958120183532 up DQTK(ub)SIVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQTKSIVEK 9 1 O95197-3;O95197-4;O95197-7;O95197-2;O95197 O95197-3 RTN3 Reticulon-3 1 21294500.0 4111400.0 3201100.0 13982000.0 True False 5631495.686407308 3059664.8173778774 10679739.568329033 1.0 0.543313000267933 1.8964303913268772 22.425086712373233 -6.8156856064660305 1.3906664049140927 0.7527271539457746 1.9232699534225688 0.8741139358729644 0.19941686945919884 0.1991523243151008 0.7579680570736977 0.11272276428757767 0.2601251379639839 1.528672290959571e-07 6.8156856064660305 1.1705427994767943 DQTK(ub)SIVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DQTKSIVEK 9 1 O95197-3;O95197-4;O95197-7;O95197-2;O95197 O95197-3 RTN3 Reticulon-3 1 19410000.0 2993200.0 4082800.0 12334000.0 True False 2488978.421243145 4060805.146027654 14912982.374027396 1.0 1.6315148059819033 5.991607740246682 21.247122291929 -6.9329423878395895 0.7222305606812895 0.9403910371658463 6.957696602338682 0.9970856042916079 0.11980617003513842 0.09113857358222732 0.07040460840714943 0.11112615882607706 0.3883278339957005 1.1669644126768045e-07 6.9329423878395895 6.017305565172836 up DQTK(ub)SIVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DQTKSIVEK 9 1 O95197-3;O95197-4;O95197-7;O95197-2;O95197 O95197-3 RTN3 Reticulon-3 1 21768100.0 1918100.0 3206000.0 16644000.0 True False 2483018.2614035695 3027583.2816995047 13614962.781861728 1.0 1.2193157532349803 5.48323103115868 21.243663441205214 -6.917564619333933 0.8425773309502667 0.8974116737433988 6.133762716842273 0.9934775842085181 0.16666465959265014 0.09962610812490609 0.11319092114740618 0.14177691771945664 0.4152951122098751 1.2090252768566334e-07 6.917564619333933 5.236351043098874 up DQVAIHEAMEQQTISITK(ub)AGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQVAIHEAMEQQTISITKAGVK 22 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 14536000.0 4666400.0 5614600.0 4255000.0 True False 6117695.5894818865 4776923.5655393815 3814733.4168420834 1.0 0.7808370808368292 0.6235572465228132 22.544556890919363 -7.1104531498963555 0.09639967363880815 1.4217345406915833 1.6573631849497533e-08 0.9999997136930238 8.239922101734612e-05 0.07803887649063856 0.0032843245433134254 0.017860596931257168 0.02990911874275111 7.754375902248429e-08 7.1104531498963555 -1.4217345241179515 DQVAIHEAMEQQTISITK(ub)AGVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQVAIHEAMEQQTISITKAGVK 22 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 19719700.0 5844700.0 5784700.0 8090300.0 True False 5659163.197727029 8094560.876811987 5971207.726202473 1.0 1.4303458999138108 1.055139694257408 22.432157311473002 -10.381707187587223 6.3269539119898335 0.9999702671717297 1.2427427970856095 0.35818176190683493 0.1531772920306591 6.425110878069977e-05 6.278731810461183e-06 0.14833141383369253 0.04943775842099108 4.152339095659764e-11 10.381707187587223 0.24277252991387988 DQVAIHEAMEQQTISITK(ub)AGVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DQVAIHEAMEQQTISITKAGVK 22 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 65350000.0 19199000.0 21913000.0 24238000.0 True False 29126286.634909414 18002453.942949552 19447348.67610719 1.0 0.61808270201436 0.6676906301127484 24.795818445508203 -10.138965083254428 6.692803362271276 1.0000006166828848 0.6428866660640109 0.9857337130834186 0.020252351839622037 1.8634802180423117e-07 2.399066828950598e-08 0.01960928924261621 0.0065364184496990016 7.261643378135462e-11 10.138965083254428 -0.35711395061887385 DQVAIHEAMEQQTISITK(ub)AGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQVAIHEAMEQQTISITKAGVK 22 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 18075300.0 4666400.0 6694400.0 6714500.0 True False 6391694.184718368 6398619.27257958 5128673.389468268 1.0 1.0010834510633768 0.8023965542234791 22.607766952442255 -6.905673196704445 0.9247121336248485 1.0070247632522789 0.7789623263907044 0.9891833713997693 0.009714668574120842 0.10734876673308777 0.1548081635172977 0.007787154060878846 0.020902781544620382 1.2425869931409818e-07 6.905673196704445 -0.22806243686157446 DQVAIHEAMEQQTISITK(ub)AGVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DQVAIHEAMEQQTISITKAGVK 22 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 20969400.0 5844700.0 11651000.0 3473700.0 True False 4860127.014111926 11588233.75045758 4200034.60942589 1.0 2.384347922762067 0.8641820671004311 22.21256258690728 -6.667037274759131 1.9479819766211897 1.88585699823094 0.8704058772572404 0.2660009627393125 0.5884434294466883 0.46791835888292777 3.4202699989087564 0.24344518565827275 0.6529224661940329 2.1525969730466552e-07 6.667037274759131 -1.0154511209736996 DQVAIHEAMEQQTISITK(ub)AGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DQVAIHEAMEQQTISITKAGVK 22 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 71107000.0 19199000.0 34395000.0 17513000.0 True False 24853483.968868744 32480888.01436504 14325813.698554695 1.0 1.3068947619195086 0.5764106841720494 24.566944767600653 -6.792567163458453 1.4859658153201298 1.170951704615085 0.5680719816297274 0.8095684827937741 0.13069047151454474 0.2315419674902509 1.0099313316746168 0.0692156712299673 0.16175974868673576 1.6122516740156618e-07 6.792567163458453 -0.6028797229853576 DQVANSAFVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQVANSAFVER 11 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 91331000.0 13492000.0 41019000.0 36820000.0 False True 17688142.65671385 34899125.09080964 33010219.60237965 1.0 1.9730237237521973 1.8662343606692946 24.076279230011085 -10.046814297237809 4.651774384732503 0.9999674391340547 1.9196290422295135 0.9899879771896616 0.04359657503775086 6967889.674830647 7524558.983701093 1967.5016339709593 0.014924267232853576 8.978126138873049e-11 10.046814297237809 0.9196616030954587 DQVANSAFVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DQVANSAFVER 11 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 309466700.0 3809900.0 299910000.0 5746800.0 False True 5779896.840999083 246388717.29247475 4610942.46108808 1.0 42.628566576611306 0.7977551482200946 22.46261231320806 -4.489253373114556 9.412540026175149 9.99999999995637 17.62533215477811 0.0 20.2509643157861 0.0 0.0 7.019302520215392 0.0 3.241504485365526e-05 4.489253373114556 7.625332154821741 DQVANSAFVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQVANSAFVER 11 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 79860000.0 13492000.0 29835000.0 36533000.0 False True 18480357.007590454 28516791.04884855 27904657.82075272 1.0 1.5430865884861327 1.5099631359551884 24.139489291533977 -10.14816583325985 4.857525668489359 0.9999616646462045 1.5265248622229417 0.99704057318664 0.013522592877918484 5.614611590363581e-06 9.846339613259236e-07 0.01309414511895995 0.0043643980833518465 7.109419920355298e-11 10.14816583325985 0.5265631975767372 DQVANSAFVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DQVANSAFVER 11 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 35982900.0 23513000.0 7571600.0 4898300.0 False True 19552101.30251572 7530810.287955063 5922511.88281971 1.0 0.3851662883408902 0.30290922654219654 24.22082032933037 -13.999999999999998 0.283486384915424 6.10840767376211 0.27898553605793736 0.9996129168566125 0.006119564354017194 15.589993696659523 0.16871960971327726 46.268038578376164 0.03200913105626058 1.0000000000000041e-14 13.999999999999998 -5.829422137704173 DQVANSAFVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DQVANSAFVER 11 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 49678900.0 3809900.0 29640000.0 16229000.0 False True 4931990.654356635 27990507.944346018 13275488.523602111 1.0 5.675296225393457 2.6917099917606926 22.233738635300508 -9.30447251824178 9.52466260117734 1.0000161336159925 4.1835031085772085 0.6028595954085642 1.218043979368197 0.0 0.0 1.1793659941703571 0.39312200391466534 4.960523161404115e-10 9.30447251824178 3.183486974961216 DQVTAQEIFQDNHEDGPTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQVTAQEIFQDNHEDGPTAK 20 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 24373300.0 2913300.0 10390000.0 11070000.0 False True 3819364.5124373357 8839852.4999028 9924582.590938166 1.0 2.314482545752521 2.598490549571759 21.864901183757084 -10.34355931044194 0.33436813406385135 3.822711803337248e-21 2.663631816131612 0.9990321525309273 0.02166254510966901 1.807356721094937 0.15711985726243674 1.6841925494645125 0.08887368776582272 4.533573797399395e-11 10.34355931044194 2.663631816131612 DQVTAQEIFQDNHEDGPTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQVTAQEIFQDNHEDGPTAK 20 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 19608000.0 5102800.0 1942200.0 12563000.0 False True 4940814.407131507 2717730.5884391987 9272373.418078631 1.0 0.5500572101061845 1.8766892771149242 22.236317433864954 -6.815208805019577 1.3926157595372568 0.7562504116592957 1.9027491746920961 0.8729741564655042 0.1963290050563288 0.19978216576725014 0.7625967480127379 0.11082320551113657 0.25579568977793804 1.5303515050469522e-07 6.815208805019577 1.1464987630328003 DQVTAQEIFQDNHEDGPTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQVTAQEIFQDNHEDGPTAK 20 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 23958900.0 2913300.0 11532000.0 9513600.0 False True 3990425.7389722313 11022478.108775636 7266683.618742326 1.0 2.7622311076047166 1.8210296580068481 21.928111245279975 -9.745572356483777 6.200186321891489 0.9999999784711484 2.2916303828080027 0.7151824330923743 0.3842438827883679 1.1434085475778765e-07 2.3247771810746794e-08 0.37204254527069075 0.12401417990895389 1.796501745542447e-10 9.745572356483777 1.2916304043368543 DQVTAQEIFQDNHEDGPTAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DQVTAQEIFQDNHEDGPTAK 20 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 10426200.0 5102800.0 2704800.0 2618600.0 False True 4243204.292369217 2690228.705539234 3166137.1529615778 1.0 0.6340087632304713 0.7461665606474365 22.01672270929923 -10.573711040801504 9.378243436659819 1.0000311456380848 0.6900876619389542 0.9105563884340163 0.04578822905766831 2.9820733111863858e-05 1.3554902222165612e-06 0.04433869735591303 0.014778087382723317 2.6686336577488776e-11 10.573711040801504 -0.3099434836991306 DQVTAQEIFQDNHEDGPTAK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 DQVTAQEIFQDNHEDGPTAKK 21 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 13112300.0 5563800.0 4347100.0 3201400.0 True False 5387180.214470144 6082919.6998270275 2362857.3000586615 1.0 1.129147245434282 0.4386074357995206 22.361098897017165 -6.85836094906462 1.1939739743542148 1.0697897275134096 0.40619821227611974 0.9516142931070856 0.06593670050500552 0.1485051838041374 0.40321346621113074 0.043099529964452835 0.10042983899190365 1.3856037528245296e-07 6.85836094906462 -0.6635915152372899 down DQVTAQEIFQDNHEDGPTAK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 DQVTAQEIFQDNHEDGPTAKK 21 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 21251900.0 4707400.0 6684000.0 9860500.0 True False 7141469.957037996 5491187.977669644 7911567.852989329 1.0 0.768915644916775 1.1078346475703358 22.767789629777155 -6.7231122795509775 1.7480839121882108 0.8598864938461294 1.1074044117551498 0.5272821354327297 0.09720498807110418 0.34925221696187625 2.0873538575046817 0.044124316438711265 0.1103664854633366 1.8918544481914095e-07 6.7231122795509775 0.24751791790902045 DQVTAQEIFQDNHEDGPTAK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DQVTAQEIFQDNHEDGPTAKK 21 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 14609800.0 5563800.0 4897500.0 4148500.0 True False 4626546.218131972 4871116.195422357 5015932.169503213 1.0 1.0528623222938718 1.0841634197547174 22.14150417245144 -13.686216792225833 0.05700341800756538 0.6614896272927298 1.237989501796727 0.9999640974339391 0.00020803793653199822 11.295847067225072 0.05755703887256085 0.5816413149325637 0.14092339424604003 2.0596015394749588e-14 13.686216792225833 0.5764998745039973 DQVTAQEIFQDNHEDGPTAK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DQVTAQEIFQDNHEDGPTAKK 21 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 36260100.0 4707400.0 13304100.0 18248600.0 True False 6093822.096726529 12563715.139756199 14927542.046448076 1.0 2.0617134764247806 2.4496189434980113 22.538915951869605 -10.074073280949348 0.24157739828762645 4.856610758103139e-16 2.681513781513313 0.9991548621815272 0.017813247098015073 1.563080404626384 0.11119879892074841 1.2163988802859036 0.1822167752459733 8.4319246915465e-11 10.074073280949348 2.6815137815133125 DQWAAAMTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQWAAAMTLR 10 0 P61086;P61086-2;P61086-3 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 0 6388100.0 1795000.0 1801600.0 2791500.0 False True 2458660.00805106 1721999.3549054982 2132205.1927471403 1.0 0.7003812439567434 0.867222464987058 21.229440817226266 -10.1267507628119 5.021571272685095 1.000008907757713 0.7838018549981145 0.6912538159412271 0.06811264326637517 6.7929257359814415e-06 1.1812529265103851e-06 0.06595250036686053 0.021983261086138888 7.468772607088698e-11 10.1267507628119 -0.2162070527595985 DQYSVIFESGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DQYSVIFESGDR 12 0 P55884;P55884-2;C9JZG1;C9JQN7 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 21954400.0 4668500.0 6443900.0 10842000.0 False True 6120448.709818316 5482495.238125465 9720173.843807723 1.0 0.8957668788777762 1.5881472592384922 22.545205994742002 -6.86855065646917 1.1416629061034618 0.9415297815193698 1.6276074204104614 0.9632189498776915 0.058457293252086324 0.13825597239457244 0.33768965870183953 0.03977032780417037 0.09393315906327138 1.353472211340886e-07 6.86855065646917 0.6860776388910915 DQYSVIFESGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DQYSVIFESGDR 12 0 P55884;P55884-2;C9JZG1;C9JQN7 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 13588000.0 4668500.0 4498200.0 4421300.0 False True 6394570.611468733 4299454.650441776 3377079.9995317673 1.0 0.6723601804835272 0.5281167735445655 22.608416056264893 -13.999999999905999 0.11136818776710501 2.577280222077831 0.2686442972914423 0.9997361190267264 0.0032072223889439773 12.0047406413977 0.10148810821481875 4.246994257320553 0.23039275818956872 1.0000000002164459e-14 13.999999999905999 -2.3086359247863886 DQYSVIFESGDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DQYSVIFESGDR 12 0 P55884;P55884-2;C9JZG1;C9JQN7 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 10484500.0 5128100.0 2857800.0 2498600.0 False True 4264242.363349251 2842404.4641711153 3021045.707778892 1.0 0.6665672872164362 0.708460132037636 22.023858007061342 -10.622507081846518 9.939115501031893 1.0000553203925984 0.6875137097272156 0.9866996201850999 0.01710268228092272 2.096889807895685e-05 7.964167925206474e-07 0.016562506065252613 0.005519866970790866 2.3850249036100975e-11 10.622507081846518 -0.3125416106653828 DRDHFQLGTLSHTLNIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DRDHFQLGTLSHTLNIK 17 1 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 10591500.0 3312100.0 2810600.0 4468800.0 False True 4342195.174422023 2391269.43563299 4006411.443756498 1.0 0.5507051939348362 0.9226695905694243 22.04999314346757 -10.009512561504513 7.0445140761944485 1.0000000277312184 0.7366873922521302 0.4005364701194595 0.15185382903949365 6.610367485704316e-08 9.330433076006229e-09 0.14703185306853317 0.049010612577315496 9.783346570892473e-11 10.009512561504513 -0.26331263547908823 DRDHFQLGTLSHTLNIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DRDHFQLGTLSHTLNIK 17 1 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 10484100.0 3312100.0 3442600.0 3729400.0 False True 4536672.876136995 3290494.5488441777 2848592.5294039743 1.0 0.7253100760586587 0.6279034453613875 22.113203204990462 -13.999999999999998 0.1444317078807315 2.3181850863006 0.5135593724730709 0.9995858710908591 0.003206165195572786 11.941121151284879 0.11937419631073432 4.4264776459771245 0.10255669931146542 1.0000000000000041e-14 13.999999999999998 -1.8046257138275292 DRDNQDREENDKDPER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DRDNQDREENDKDPER 16 3 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 9018900.0 2967800.0 1069800.0 4981300.0 False True 2873588.8134915885 1496976.7189332996 3676548.094203228 1.0 0.5209432580976608 1.2794273408017602 21.454422208302194 -6.736015102864522 1.701321298389509 0.7136527119737902 1.2794929500791103 0.5868921130516094 0.2013073499936183 0.32508188930791115 1.8459509466522952 0.09366776916547086 0.23086225405120198 1.8364744776796233e-07 6.736015102864522 0.5658402381053201 DRDYSDHPSGGSYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DRDYSDHPSGGSYR 14 1 P38159;P38159-2;H3BT71;H0Y6E7;Q96E39;H3BUY5 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 7166420.0 2231000.0 755020.0 4180400.0 False True 2160178.1261876584 1056503.4233772864 3085427.830688206 1.0 0.4890816227464689 1.428321022828545 21.042718849848132 -6.758977052096962 1.6162452074428406 0.7028546355570947 1.431589179455287 0.6868110533034648 0.21486364751158732 0.2846374616090425 1.4652067862208458 0.10490090726130472 0.2523563055427221 1.74189891202656e-07 6.758977052096962 0.7287345438981924 DREDYVPYTGEK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DREDYVPYTGEKK 13 2 Q9NYL9 Q9NYL9 TMOD3 Tropomodulin-3 1 27695800.0 5235800.0 12072000.0 10388000.0 True False 6777846.313047703 11400182.587859131 8497490.589881 1.0 1.6819771445559621 1.2537154425474197 22.69239549355864 -10.111632863869477 4.2343772715354095 0.9999236551397614 1.467846293508512 0.6140794414109493 0.17483710795527646 22456770.932326164 13406622.490787651 15511.477355191571 0.05985139231201971 7.733340562114888e-11 10.111632863869477 0.4679226383687505 DREIQLEISGK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DREIQLEISGKER 13 2 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 9979500.0 2411200.0 3503400.0 4064900.0 True False 3161106.550094016 2980706.376146241 3644303.141274121 1.0 0.942931321330371 1.152856787179709 21.59199823370342 -6.834296588449733 1.3087135388920006 0.9695856460553645 1.1590133403521905 0.9141764101207798 0.025963504676726496 0.1755700948537042 0.5865789016213606 0.015569776848136483 0.035831424910571855 1.4645473304878942e-07 6.834296588449733 0.18942769429682604 DREIQLEISGK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DREIQLEISGKER 13 2 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 9049000.0 2874400.0 2450100.0 3724500.0 True False 2783153.7453670106 3428437.707102708 2748941.717395038 1.0 1.2318535089230598 0.9877074602763416 21.408289176718792 -6.657865316714555 1.98040660887191 1.1495041570912727 0.9887281495586367 0.226551325709487 0.09876886609127301 0.48955423283620114 3.6886872253924787 0.04032440566696818 0.10946997626914419 2.1985415781845924e-07 6.657865316714555 -0.160776007532636 DREIQLEISGK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DREIQLEISGKER 13 2 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 35040600.0 9538600.0 11227000.0 14275000.0 True False 14470753.56506834 9223454.133048622 11453539.993045231 1.0 0.6373858895167401 0.7914957532476741 23.786636716439123 -10.161565495893932 5.280340448051356 1.0000106776701714 0.7144408224308859 0.820722349553747 0.06291508841222229 7.90884490684327e-06 1.2557172788489118e-06 0.06091954893901723 0.020305757470410496 6.893416258111695e-11 10.161565495893932 -0.28556985523928546 DREIQLEISGK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DREIQLEISGKER 13 2 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 9622200.0 2411200.0 3606400.0 3604600.0 True False 3302685.800229924 3447057.323230012 2753267.7190672904 1.0 1.0437133689768603 0.8336450651392923 21.655208295226313 -6.852409111707612 1.2234055812313023 1.0233841098008074 0.8248486842417901 0.9437392276380064 0.021466198283594154 0.15482619512072718 0.44471894893863373 0.013720948728286135 0.0318039470749718 1.4047236306086952e-07 6.852409111707612 -0.19853542555901726 DREIQLEISGK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DREIQLEISGKER 13 2 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 11389600.0 2874400.0 6619500.0 1895700.0 True False 2390190.95751079 6583839.439632127 2292082.1052735285 1.0 2.7545244529285298 0.9589535505818185 21.18869445215307 -6.651461450267333 2.0034680295598557 2.137193667361945 0.9665148012440489 0.1999879327771107 0.7485815222390951 0.5049224476040107 3.886442992522752 0.30286499190862237 0.8291409877812164 2.2312002490399995e-07 6.651461450267333 -1.1706788661178962 DREIQLEISGK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DREIQLEISGKER 13 2 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 50105600.0 9538600.0 17207000.0 23360000.0 True False 12347905.733915906 16249415.323831365 19108719.693840995 1.0 1.3159652878786732 1.5475271763174552 23.557763038531572 -6.9745191456911675 0.10376120457228788 0.46211176462850395 2.407267463497164 0.9999997016701831 0.00012243605981616086 0.07486165023615814 0.0030534825600138523 0.01989410639801415 0.03695656466116067 1.0604271888513695e-07 6.9745191456911675 1.9451556988686598 DREVGIPPEQSLETAK(ub)AVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DREVGIPPEQSLETAKAVK 19 2 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 8681900.0 2153400.0 2344400.0 4184100.0 True False 2085041.4957115643 3280531.145884494 3088158.689690585 1.0 1.5733649198981259 1.481101789121317 20.99164466525386 -10.68856883290837 6.565797091229193 0.9952443620713183 1.5272333545096102 0.9775482551163592 0.0376662654124761 0.0026321363244811505 0.000124848290803478 0.036609659556373145 0.012156734888029024 2.0484773536179086e-11 10.68856883290837 0.5319889924382919 DREVGIPPEQSLETAK(ub)AVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DREVGIPPEQSLETAKAVK 19 2 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 36412800.0 7606800.0 10006000.0 18800000.0 True False 11540071.731570864 8220351.122765165 15084171.759667268 1.0 0.7123310247956482 1.3071124782006855 23.460148855825775 -6.775171686273644 1.554467830493493 0.8360939499246166 1.3111475668029617 0.7500095223888016 0.12142856503705068 0.25814879675639224 1.2316599242747321 0.06154561045961841 0.14583175353420072 1.6781404806976752e-07 6.775171686273644 0.47505361687834513 DREVGIPPEQSLETAK(ub)AVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DREVGIPPEQSLETAKAVK 19 2 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 9319000.0 2513900.0 3551600.0 3253500.0 True False 3443356.765593065 3394678.5684293774 2485090.307935815 1.0 0.9858631560777864 0.7217057299340855 21.715384235357405 -6.91796485000577 0.8396810707836407 1.006266880892027 0.6810399161700279 0.9935966950302921 0.010241624235404046 0.09938414972714124 0.11192794749694673 0.008730401036885115 0.025663939234176064 1.2079115945055332e-07 6.91796485000577 -0.3252269647219991 DREVGIPPEQSLETAK(ub)AVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DREVGIPPEQSLETAKAVK 19 2 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 8511600.0 2153400.0 3218200.0 3140000.0 True False 1790647.511795065 3200862.917837315 3796559.48228036 1.0 1.787544950501484 2.120215987385722 20.772049940688138 -10.232493859330901 0.19623806964673893 6.483351168311133e-24 2.4190902105772634 0.9994247839280659 0.011265743573053067 1.8383106946260948 0.09505416507756005 1.1450814301789676 0.2074853955864169 5.854720144927403e-11 10.232493859330901 2.4190902105772634 DREVGIPPEQSLETAK(ub)AVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DREVGIPPEQSLETAKAVK 19 2 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 28253500.0 7606800.0 8282700.0 12364000.0 True False 9847152.552444963 7821760.463921541 10113878.86535317 1.0 0.7943169786660272 1.027086643726463 23.231275177918224 -6.673477149605649 1.925171640354038 0.8691058619733796 1.0261585036648864 0.294466157852742 0.08730065611742271 0.4531945443187174 3.2415091557130657 0.03646513443859481 0.09698168594200102 2.1209129819430614e-07 6.673477149605649 0.1570526416915068 DRFNHFSLTLNTNHGHILVDYSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DRFNHFSLTLNTNHGHILVDYSK 23 1 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 0 543688000.0 80168000.0 161780000.0 301740000.0 False True 121620717.06585863 132909095.0070908 242100956.74265996 1.0 1.092816242278192 1.9906226717242612 26.857813759775233 -6.926742994556881 0.7730492903948486 0.9845737493384874 2.160533939179532 0.995858816070554 0.028747144294072435 0.0943639241123485 0.08622287072453687 0.025699671511440834 0.08273795041674305 1.1837418595835057e-07 6.926742994556881 1.1759601898410446 DRFNHFSLTLNTNHGHILVDYSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DRFNHFSLTLNTNHGHILVDYSK 23 1 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 0 386944000.0 80168000.0 233220000.0 73556000.0 False True 103779056.34753223 220241101.9831434 60169562.748294815 1.0 2.122211453201179 0.5797852174219119 26.628940081867682 -6.7115749553921 1.7893686453927646 1.6887829412844133 0.5832004482477218 0.47269805172851076 0.4727774043787529 0.3719096294980433 2.322163980692251 0.21017314963222664 0.5329656806914822 1.942786355124024e-07 6.7115749553921 -1.1055824930366915 DRGEEDADGSK(ub)TQDLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DRGEEDADGSKTQDLFR 17 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 5279800.0 2618100.0 2661700.0 0.0 True False 3389182.060466446 2513574.0551776555 0.0 1.0 0.7416462173860667 0.0 21.69250570708359 -7.349249085085623 0.7885986633515241 0.9894408420505847 8.959743797377481e-23 0.9878284354676338 0.04676039666508307 0.10881498653288062 0.1378945656940389 0.04015349361597479 0.07148186430305965 4.474565964877626e-08 7.349249085085623 -0.9894408420505847 down DRPASGSPFQLFLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DRPASGSPFQLFLSK 15 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2;A0A087WWG9 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 0 8223300.0 2620600.0 2391300.0 3211400.0 False True 3435631.977926496 2034527.3612143914 2879115.1339240093 1.0 0.59218431260565 0.8380161648342903 21.71214407377014 -10.3107811411482 5.781955520105244 1.0000294889493715 0.7151002387199688 0.6416795474542168 0.1003604334139125 3.8154229048744165e-05 4.548073359447357e-06 0.09718361521915257 0.03239119060251938 4.888986734234805e-11 10.3107811411482 -0.28492925022940274 DRPASGSPFQLFLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DRPASGSPFQLFLSK 15 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2;A0A087WWG9 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 0 6253600.0 1617200.0 1017900.0 3618500.0 False True 1565862.8712105246 1424352.778278375 2670706.297326877 1.0 0.909628042446174 1.7055812143129934 20.578526444988324 -6.878667341006136 1.0871511521035944 0.9449110280262661 1.7605798327491795 0.9725968514270077 0.05890420719739707 0.12881963515188277 0.2794452934814654 0.04178500412204573 0.10071793346563289 1.3223081021694275e-07 6.878667341006136 0.8156688047229134 DRPASGSPFQLFLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DRPASGSPFQLFLSK 15 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2;A0A087WWG9 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 0 8870100.0 2620600.0 2760000.0 3489500.0 False True 3589506.639052143 2638054.073900515 2665351.9685083847 1.0 0.7349350033789402 0.7425399188597702 21.775354135293032 -10.528628215235793 6.205348986955037 1.000310492215203 0.7387374611193552 0.999364930335608 0.0031046937441710047 1.3351953347249691e-05 1.0142445172366614e-06 0.0030096200315091327 0.0010020355971873838 2.9605458048147214e-11 10.528628215235793 -0.26157303109584784 DRPASGSPFQLFLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DRPASGSPFQLFLSK 15 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2;A0A087WWG9 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 0 4168960.0 1617200.0 844660.0 1707100.0 False True 1344773.454107449 840109.6489281167 2064046.7172614043 1.0 0.6247220647924769 1.5348657507753605 20.3589317204226 -6.794730519929886 1.477238180892504 0.7915347233382347 1.54586497646872 0.816308108464413 0.1600639113409896 0.22838306552151005 0.9843727727261458 0.0852622638219956 0.19896666445281022 1.604240514430827e-07 6.794730519929886 0.7543302531304853 DRPFFAGLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DRPFFAGLVK 10 1 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 222331000.0 52251000.0 64050000.0 106030000.0 False True 68501566.99940386 54493989.6649445 95059032.71157837 1.0 0.7955144977255592 1.387691360584578 26.029633654860053 -6.813474426892481 1.3999419623521454 0.8890048946837719 1.398888326227494 0.8686820140775848 0.08899338161034195 0.20210728231394712 0.779996280014095 0.049975999077320185 0.11543018219432756 1.5364752648709702e-07 6.813474426892481 0.5098834315437222 DRPFFAGLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DRPFFAGLVK 10 1 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 147025000.0 48395000.0 18377000.0 80253000.0 False True 46858727.2150837 25715031.93478897 59232331.76160662 1.0 0.5487778576817888 1.264061900139274 25.481814432210605 -6.736209357775213 1.7003195679905168 0.7303413577799968 1.2641592827388874 0.5877857363469501 0.18961137830486968 0.32478460320542485 1.8421171881435217 0.08826840231445995 0.21753191447829062 1.8356532275172935e-07 6.736209357775213 0.5338179249588907 DRPFFAGLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DRPFFAGLVK 10 1 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 237905000.0 32697000.0 186100000.0 19108000.0 False True 49603739.470890775 152889000.9940634 15331295.424666084 1.0 3.0822071606876347 0.30907539609313184 25.56394554919368 -6.705780968187316 1.8101673025582576 2.285576492399719 0.3163474517402942 0.44506493102543 0.8780329693682243 0.3836281616032071 2.4476304008638237 0.3863885090620778 0.986691517399168 1.9688790225875477e-07 6.705780968187316 -1.9692290406594248 DRPFFAGLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DRPFFAGLVK 10 1 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 181128000.0 52251000.0 56278000.0 72599000.0 False True 71569606.73018162 53791451.8735411 55452611.42333863 1.0 0.751596303670294 0.7748067085571075 26.092843716382944 -9.993623623693345 5.022938731478628 1.0000020864694075 0.7632015061110025 0.992845968248827 0.009475608125379677 13052745.268499773 4.076393404861485 314.984155586378 0.003243752696296251 1.0147904612171275e-10 9.993623623693345 -0.236800580358405 DRPFFAGLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DRPFFAGLVK 10 1 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 107327000.0 48395000.0 27688000.0 31244000.0 False True 40242586.762014605 27538839.248362303 37776975.944066145 1.0 0.6843208020205227 0.9387313039161842 25.26221970764488 -9.929441385650717 6.178990797424564 1.0000000457383396 0.811526054046568 0.4225542681365616 0.10386265247504929 6.549834038462458e-08 1.1155927018973234e-08 0.1005646063071133 0.033521526944052686 1.1764097475558164e-10 9.929441385650717 -0.1884739916917716 DRPFFAGLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DRPFFAGLVK 10 1 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 103899000.0 32697000.0 43580000.0 27622000.0 False True 42326911.0542268 41154734.69010121 22595079.425653934 1.0 0.9723065932540206 0.5338230185686459 25.33507187128613 -6.919778833610318 0.8263666807889021 1.0097522605401463 0.46347235679789645 0.9941192120238536 0.01637482773755984 0.09830218602152949 0.10629039672909245 0.014092069163491174 0.04212353091873076 1.2028768490332648e-07 6.919778833610318 -0.5462799037422499 DRPFFPGLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DRPFFPGLVK 10 1 Q32Q12;P22392-2;J3KPD9;P22392;O60361;F6XY72 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 100370000.0 11832000.0 46613000.0 41925000.0 False True 15511866.581250992 39658522.09605086 37587003.172997475 1.0 2.556656988268945 2.4231128456473727 23.886868964092027 -10.12894725348923 4.8242562677254694 0.9999064659964739 2.489884916967628 0.9940104189421433 0.05451916795934177 5.4850398443875765e-05 9.903508268931654e-06 0.05279121191376329 0.01759598579166108 7.431093855251387e-11 10.12894725348923 1.489978450971154 DRPFFPGLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DRPFFPGLVK 10 1 Q32Q12;P22392-2;J3KPD9;P22392;O60361;F6XY72 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 96233000.0 31193000.0 13432000.0 51608000.0 False True 30202795.289184917 18795467.646954644 38090316.59318653 1.0 0.6223088779363732 1.2611520300846455 24.84817874234541 -6.746513778618681 1.6626728925778596 0.7769852772370732 1.2620964790919174 0.6338444835551453 0.15868901927226983 0.3061761388501292 1.6641871815546447 0.0754298405567488 0.1838038922561851 1.792611678272929e-07 6.746513778618681 0.48511120185484413 DRPFFPGLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DRPFFPGLVK 10 1 Q32Q12;P22392-2;J3KPD9;P22392;O60361;F6XY72 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 111404000.0 11832000.0 46169000.0 53403000.0 False True 16206610.14777723 44129100.91953366 40790311.269308776 1.0 2.7229075369339997 2.5168934710818136 23.95007902561492 -10.027477700755458 7.33040632997684 0.9999998796489417 2.619900504007907 0.9880148955509488 0.08410489019566557 1.6542603927960952e-07 2.2016620542114714e-08 0.08143421583258353 0.02714473658853454 9.38690233337198e-11 10.027477700755458 1.6199006243589653 DRPFFPGLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DRPFFPGLVK 10 1 Q32Q12;P22392-2;J3KPD9;P22392;O60361;F6XY72 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 41233400.0 31193000.0 4543000.0 5497400.0 False True 25938361.584203325 4518525.957285103 6646880.92289429 1.0 0.1742024430732326 0.25625677633171307 24.628584017779687 -10.291257083088523 5.609568566181147 1.0000829851951574 0.2152296106687388 0.9918673386091054 0.03349854127797171 3.4769892639085544e-05 4.3930236155971065e-06 0.03243821521278386 0.01081160770764565 5.113790321995971e-11 10.291257083088523 -0.7848533745264186 DRPFKPYNFLAHGVLPDSGHLHPLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DRPFKPYNFLAHGVLPDSGHLHPLLK 26 2 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 177648000.0 45507000.0 102425000.0 29716000.0 False True 44062405.19427246 143323836.63931894 21932488.139108874 1.0 3.2527465536073183 0.49775966705421276 25.393044912476427 -6.689324536020355 1.8685043345997574 2.413212903490696 0.5072833814720664 0.36735692723743185 0.9528840302537396 0.4181501725475665 2.829865227412872 0.4080207945492681 1.063542155541692 2.04491595759259e-07 6.689324536020355 -1.9059295220186296 DRPFKPYNFLAHGVLPDSGHLHPLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DRPFKPYNFLAHGVLPDSGHLHPLLK 26 2 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 47368900.0 8159900.0 13215000.0 25994000.0 False True 12379164.868597172 10856680.000733733 20856274.50642507 1.0 0.8770123118946739 1.6847884916156335 23.56141065400012 -6.868085888071581 1.1442386155063131 0.93119238007802 1.7303932304151215 0.9627317481229333 0.06860331904938316 0.13869986937601772 0.3406095763651003 0.046583920644748276 0.10993229169776172 1.35492143036762e-07 6.868085888071581 0.7992008503371015 DRPFKPYNFLAHGVLPDSGHLHPLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DRPFKPYNFLAHGVLPDSGHLHPLLK 26 2 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 104165800.0 45507000.0 39469000.0 19189800.0 False True 37841086.80192168 39256372.66301694 23202298.456389725 1.0 1.0374007720365839 0.6131509535611817 25.173450187910703 -6.885409696406736 1.0491258340386238 1.025366341291549 0.579777644386228 0.9777950433966376 0.028578749600325828 0.12294788248747222 0.24422183300872227 0.02087040591490278 0.05124208832345604 1.3019380016281728e-07 6.885409696406736 -0.445588696905321 DRPFKPYNFLAHGVLPDSGHLHPLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DRPFKPYNFLAHGVLPDSGHLHPLLK 26 2 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 53943300.0 8159900.0 24300700.0 21482700.0 False True 10563151.405675914 22948344.682967898 17573069.03111637 1.0 2.1724903678496013 1.663619913814149 23.33253697609257 -10.494361296006227 5.5776791722290575 0.9986114004947735 1.918055140831798 0.8127242939122432 0.20774549292754782 0.0035915540938228083 0.000325587966491227 0.20138840291866553 0.06704956952983622 3.2036030908011334e-11 10.494361296006227 0.9194437403370246 DRSDCLGEHLYVMVNAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DRSDCLGEHLYVMVNAK 17 1 P54105;E9PMI6;E9PJF4;J3KN38 P54105 CLNS1A Methylosome subunit pICln 0 65779000.0 11638000.0 32603000.0 21538000.0 False True 17655696.851767052 26784739.921598338 17281004.859559238 1.0 1.517059346140598 0.9787778417723392 24.073630428087206 -6.655321433939815 1.98938979113857 1.3341046782462045 0.9810332674713784 0.21586337977274284 0.22040205406561514 0.4956964104724864 3.766117990457207 0.08966140547112328 0.24423465716518292 2.211457340042389e-07 6.655321433939815 -0.35307141077482607 DRSDCLGEHLYVMVNAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DRSDCLGEHLYVMVNAK 17 1 P54105;E9PMI6;E9PJF4;J3KN38 P54105 CLNS1A Methylosome subunit pICln 0 49204000.0 11638000.0 20536000.0 17030000.0 False True 15065620.41927675 19393153.547405165 13930714.742556171 1.0 1.287245596775507 0.9246691709245213 23.844756750179656 -6.695579260746072 1.8468033259175691 1.179134531898692 0.9258375462071984 0.39660554888332433 0.1213504739313522 0.40476036258925224 2.680734797394072 0.05248577695489548 0.13571254526567056 2.015676066914071e-07 6.695579260746072 -0.2532969856914937 DRYDSFIELQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DRYDSFIELQEK 12 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 8298500.0 2303500.0 2443900.0 3551100.0 False True 3019910.8071257295 2079279.6462475862 3183666.2365565053 1.0 0.6885235290199146 1.0542252536215246 21.52607450959717 -6.6811020159324235 1.8979160146437668 0.8031201775010721 1.0528469826659599 0.329182023898846 0.13197949790643335 0.43609016775924114 3.037983328621181 0.055778767921504185 0.14690840624831342 2.0840012929322026e-07 6.6811020159324235 0.24972680516488777 DRYDSFIELQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DRYDSFIELQEK 12 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 7844900.0 2303500.0 2408800.0 3132600.0 False True 3155166.1997468574 2302371.251163611 2392744.3979221527 1.0 0.7297147298764588 0.7583576415448813 21.58928457112006 -10.02771211821018 5.807129671809477 1.0000005780649983 0.7440361858814467 0.9906958035089478 0.011693419722716272 8.751368998710808e-08 1.4657128531566633e-08 0.011322130520792686 0.003774034987165535 9.38183696854234e-11 10.02771211821018 -0.2559643921835516 DSAQNSVIIVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSAQNSVIIVDK 12 0 P02786;G3V0E5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 0 4524900.0 1043100.0 1450900.0 2030900.0 False True 1367514.2013947696 1234431.3755639044 1820761.9497684124 1.0 0.9026826736459995 1.3314391528156428 20.38312438455438 -6.847047964612738 1.2492501958819449 0.9481715339093225 1.3476280727043017 0.9359027903000962 0.04646548254493871 0.16073033456366062 0.48418931969969914 0.02912583865097396 0.06728409626884717 1.4221717101044267e-07 6.847047964612738 0.3994565387949792 DSDDALLK(ub)MTISQQEFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSDDALLKMTISQQEFGR 18 1 Q5VWC4 Q5VWC4 PSMD4 1 10080300.0 2403200.0 3804600.0 3872500.0 True False 3150618.4726219033 3236968.510214644 3471810.847643 1.0 1.0274073291777792 1.1019458172457819 21.587203629619868 -6.953633998901532 0.5174257512060058 0.9987077293574771 1.133957146621271 0.9994563911899202 0.0010043251089647109 0.08205868770786652 0.030172610023317496 0.0011424935256352836 0.006155406585680984 1.1126690326208215e-07 6.953633998901532 0.13524941726379391 DSDDALLK(ub)MTISQQEFGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 DSDDALLKMTISQQEFGR 18 1 Q5VWC4 Q5VWC4 PSMD4 1 155826900.0 40239900.0 48355200.0 67231800.0 True False 38962506.40070762 67663683.52903675 49621774.669233434 1.0 1.7366358014331407 1.2735775814548786 25.21558315106618 -10.223716663937333 4.639804568520307 0.9998736485725302 1.5051066914469122 0.6133737145933977 0.18904272670129163 0.0002471432264189332 4.1349939462543193e-05 0.18308528065194027 0.06101327768490965 5.974249227118702e-11 10.223716663937333 0.505233042874382 DSDDALLK(ub)MTISQQEFGR ddPTM_RPMI8226_Bortezomib_8h_R1 2 DSDDALLKMTISQQEFGR 18 1 Q5VWC4 Q5VWC4 PSMD4 1 204864300.0 45963400.0 101370600.0 57530300.0 True False 69729838.17464423 83280224.41788724 46159410.98857373 1.0 1.1943269423529268 0.66197501954563 26.055272797709055 -6.8079178324058764 1.4232372314075026 1.1061699789493062 0.6530959843252458 0.8543302693473749 0.08394963175300652 0.20965281038053968 0.8373729961177141 0.04638515481982861 0.10740470170982672 1.5562600448501155e-07 6.8079178324058764 -0.4530739946240604 DSDDALLK(ub)MTISQQEFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSDDALLKMTISQQEFGR 18 1 Q5VWC4 Q5VWC4 PSMD4 1 15090100.0 2403200.0 2522300.0 10164600.0 True False 3291727.9840380503 2410856.4458693047 7763930.826508188 1.0 0.7323984416573337 2.3586185930782673 21.65041369114276 -6.864654057930168 1.161929897857788 0.8525775664887825 2.444689620266128 0.9590542583506445 0.14406649694372686 0.1420877162301688 0.36189876260802245 0.09650211429738566 0.22659141439535285 1.3656705434046205e-07 6.864654057930168 1.5921120537773457 up DSDDALLK(ub)MTISQQEFGR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DSDDALLKMTISQQEFGR 18 1 Q5VWC4 Q5VWC4 PSMD4 1 136302900.0 40239900.0 54293300.0 41769700.0 True False 33461259.77982829 54000811.21652374 50503551.14872806 1.0 1.6138307873595799 1.509314098782781 24.995988426500457 -10.065361699320684 4.461716281472665 0.9999631637971259 1.5615724430284539 0.9746789013305226 0.04266875958107931 6302518.895035374 4739367.6896228455 2070.6424083376396 0.014606651669320285 8.602769776874976e-11 10.065361699320684 0.561609279231328 DSDDALLK(ub)MTISQQEFGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DSDDALLKMTISQQEFGR 18 1 Q5VWC4 Q5VWC4 PSMD4 1 188058000.0 45963400.0 100682900.0 41411700.0 True False 59500527.37406641 95079808.10761797 33875195.51992443 1.0 1.5979658047377066 0.5693259709608741 25.826399119801504 -6.749116580358168 1.6532086993377737 1.3519809494549841 0.5674289176853592 0.645143933277464 0.2512580243883132 0.30157754416243454 1.6214379129940026 0.12007610620242386 0.2917724335674727 1.78190037668554e-07 6.749116580358168 -0.784552031769625 DSDEADLVLAK(ub)EANMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSDEADLVLAKEANMK 16 1 Q13185 Q13185 CBX3 Chromobox protein homolog 3 1 40358900.0 15839300.0 14723700.0 9795900.0 True False 20765475.687999405 12526981.352533089 8782314.236907965 1.0 0.6032600235482478 0.4229286325467304 24.307683585088487 -13.999999999999998 0.10619835617352893 2.9286201518485724 0.07324764866936027 0.9997623891436838 0.0037156478261881716 12.036332255646641 0.0982453241574345 5.0149327830705985 0.31095618870675035 1.0000000000000041e-14 13.999999999999998 -2.855372503179212 DSDEADLVLAK(ub)EANMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSDEADLVLAKEANMK 16 1 Q13185 Q13185 CBX3 Chromobox protein homolog 3 1 46994400.0 16702700.0 19086300.0 11205400.0 True False 16172481.931095757 26707559.12373959 8270369.585205632 1.0 1.6514199389759365 0.5113853037797321 23.947037765095686 -6.7517298529710015 1.643518418303423 1.3822431651127287 0.5088269704081637 0.656360661855256 0.27375686808656996 0.297032524094314 1.5791126515615435 0.1315546433434411 0.318791730656005 1.7712103732618632e-07 6.7517298529710015 -0.873416194704565 DSDEADLVLAK(ub)EANMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSDEADLVLAKEANMK 16 1 Q13185 Q13185 CBX3 Chromobox protein homolog 3 1 40958800.0 16205800.0 9763200.0 14989800.0 True False 24585383.402678024 8020880.679770232 12027059.459737256 1.0 0.32624590588636243 0.48919552169469843 24.5512975180005 -10.423219898317285 9.066763661762803 1.0000034913844906 0.4077207137933997 0.9462801735927299 0.06652390208549644 4.695021985716573e-06 2.985282284425228e-07 0.06441187096608131 0.021470497075155043 3.7738106145774055e-11 10.423219898317285 -0.5922827775910909 DSDEADLVLAK(ub)EANMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSDEADLVLAKEANMK 16 1 Q13185 Q13185 CBX3 Chromobox protein homolog 3 1 43088500.0 15839300.0 16023400.0 11225800.0 True False 21695517.250987828 15315433.205702003 8574497.242608221 1.0 0.7059261610830998 0.395219765604704 24.37089364661138 -6.994058339030476 0.2504002247452696 1.0993218529318936 1.933783680338322e-09 0.9999856711618562 0.0009347035825053144 0.07372452823785244 0.008542361649325722 0.006904366608302561 0.028987853387237743 1.0137751955776819e-07 6.994058339030476 -1.09932185099811 down DSDEADLVLAK(ub)EANMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSDEADLVLAKEANMK 16 1 Q13185 Q13185 CBX3 Chromobox protein homolog 3 1 46770000.0 16702700.0 23369000.0 6698300.0 True False 13889035.105070809 23243106.55861671 8098883.560560046 1.0 1.6734860544870234 0.5831134775952282 23.727443040529963 -6.739642037625577 1.6882924708279325 1.400892159675267 0.5825586293684154 0.6032271558160167 0.2829712639885597 0.3184565404950406 1.78220405370181 0.13261018615915862 0.3255055112923215 1.8212013450061614e-07 6.739642037625577 -0.8183335303068516 DSDEADLVLAK(ub)EANMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSDEADLVLAKEANMK 16 1 Q13185 Q13185 CBX3 Chromobox protein homolog 3 1 49787300.0 16205800.0 18383500.0 15198000.0 True False 20978727.564075913 17360442.064604748 12432119.944648782 1.0 0.8275259789508331 0.5926060056157844 24.32242384009295 -6.966810709713844 0.32548142088692966 1.030171382947294 0.3823217491603867 0.9999457506371708 0.0012297746813345449 0.07735176875934957 0.012721504847072383 0.003485242133287817 0.02056661351318631 1.0794170912011487e-07 6.966810709713844 -0.6478496337869073 DSDLSHVQNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSDLSHVQNK 10 0 O60506;O60506-2;O60506-3;O60506-4;F6UXX1 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 8247580.0 3467200.0 946680.0 3833700.0 False True 3357135.633849324 1324694.260870983 2829538.961465262 1.0 0.39459062884274226 0.8428432062546383 21.6787993948103 -9.824923628694371 6.252071538650871 1.0000000171627164 0.6187169175485608 0.4910141031800773 0.18299834842503318 4.3535024285435426e-08 8.446154393887567e-09 0.17718739687901927 0.059062462986045505 1.4964987944099313e-10 9.824923628694371 -0.3812830996141555 DSDSMETEEK(ub)TSSAFVGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 DSDSMETEEKTSSAFVGK 18 1 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 162683500.0 23316500.0 103159800.0 36207200.0 True False 30568157.297307175 87768759.953751 32460826.26798702 1.0 2.871247982013059 1.0619163580019453 24.865526250843896 -6.63828222451914 2.050194254831569 2.225242389123749 1.0693427473952244 0.14822833282048897 0.8009876760992065 0.5377122358947071 4.317345059912454 0.3183542161039281 0.8872135602646426 2.299946720560726e-07 6.63828222451914 -1.1558996417285246 DSDSMETEEK(ub)TSSAFVGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 DSDSMETEEKTSSAFVGK 18 1 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 140429900.0 20932000.0 80689600.0 38808300.0 True False 20267525.1175975 112909378.07070525 28643242.005955655 1.0 5.570950444890306 1.4132579996699175 24.272666595218706 -6.623572931436099 2.10369906791684 4.0253536038239535 1.4294582273153038 0.0948877748645075 1.963889472897459 0.5759142194634902 4.848073030247504 0.765773667636255 2.1767787826696803 2.3791787299303354e-07 6.623572931436099 -2.5958953765086497 DSDSMETEEK(ub)TSSAFVGK ddPTM_RPMI8226_Bortezomib_8h_R1 2 DSDSMETEEKTSSAFVGK 18 1 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 129218700.0 40463700.0 67920700.0 20834300.0 True False 61386391.19271746 55799720.41814876 16716391.47300193 1.0 0.9089917053923269 0.27231428901761323 25.87141552282186 -6.9326792507862995 0.7244606500316464 1.0087849607253454 0.13221794679325313 0.997039141957346 0.01761496744124341 0.09127030673990036 0.07103812811433224 0.016311911632462362 0.0567834592947917 1.1676716853571467e-07 6.9326792507862995 -0.8765670139320922 down DSDSMETEEK(ub)TSSAFVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DSDSMETEEKTSSAFVGK 18 1 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 133677000.0 23316500.0 82442000.0 27918500.0 True False 31937240.15472004 78799439.84076318 21324725.29955618 1.0 2.4673215174203875 0.6677072031349138 24.928736312366787 -6.689891431536211 1.8665901502289584 1.9199935248980846 0.6738961993950471 0.37003122740826777 0.6205846378301854 0.41689121693016906 2.8160353584999003 0.26596716776983487 0.6927457808621 2.042248418716261e-07 6.689891431536211 -1.2460973255030376 DSDSMETEEK(ub)TSSAFVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DSDSMETEEKTSSAFVGK 18 1 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 151139600.0 20932000.0 106429700.0 23777900.0 True False 17405885.444828782 105856342.08145846 28749748.953412164 1.0 6.081640742551707 1.6517257363631332 24.053071870652982 -6.612901621468216 2.1424160150330436 4.3882802476013 1.6677122905214306 0.059690289912480377 2.1892123160427697 0.6046655605621559 5.2631983850385815 0.8424709404438789 2.430185125641629 2.438363105871042e-07 6.612901621468216 -2.7205679570798695 DSDSMETEEK(ub)TSSAFVGK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DSDSMETEEKTSSAFVGK 18 1 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 101142000.0 40463700.0 49132000.0 11546300.0 True False 52381057.30877197 46397761.00950087 9444991.875042662 1.0 0.8857736631011244 0.18031312005343889 25.64254184491431 -6.935226244553857 0.7025706915081701 1.0089365749688404 0.01411799735190164 0.9974693620233176 0.018235357838687623 0.09001352896526224 0.06504231039088404 0.017164116684740802 0.06210060897487919 1.1608437178509616e-07 6.935226244553857 -0.9948185776169387 down DSDVTLKNK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSDVTLKNK 9 1 A0A1B0GU48;A0A1B0GV09;Q9H9B1-3;Q9H9B1;A0A0C4DGF8;A0A1B0GWF6 A0A1B0GU48 EHMT1 Histone-lysine N-methyltransferase EHMT1 1 7814000.0 3725300.0 2894400.0 1194300.0 True False 3097752.0087722484 2878807.2927065855 1444022.6081807145 1.0 0.9293214190659379 0.4661517784804966 21.56279022280124 -6.933998183502053 0.713207398407938 1.006107043177434 0.36059921350500684 0.9972673929471724 0.012376690987310292 0.09061424305175443 0.06789447989055475 0.01155708044310071 0.041026592239720376 1.1641308985420425e-07 6.933998183502053 -0.645507829672427 down DSEEPFSSVEIQAALSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSEEPFSSVEIQAALSK 17 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 68740800.0 8480800.0 33409000.0 26851000.0 False True 12865993.629529636 27446902.924291555 21543888.0807886 1.0 2.133290573166169 1.6744830365329675 23.617059543672624 -10.220773468559555 5.013318186074433 0.9998879005440632 1.9038868048503506 0.8380552390731391 0.1873073924851549 0.0002347140118400144 3.648164007791042e-05 0.181381782048092 0.0604532009759899 6.014873962611001e-11 10.220773468559555 0.9039989043062874 DSEEPFSSVEIQAALSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSEEPFSSVEIQAALSK 17 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 12786200.0 5235800.0 3246500.0 4303900.0 False True 4353799.685268227 3229010.460120207 5203825.591014796 1.0 0.7416534277050175 1.195237715833084 22.053843601168573 -6.752200696938247 1.641578016801879 0.8484924054400333 1.1962992358157123 0.6584238397621168 0.10857325139499031 0.2962281490114771 1.5712231467972706 0.0522315420684691 0.12651856335344183 1.7692911413980247e-07 6.752200696938247 0.34780683037567894 DSEIMQQK(ub)QK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSEIMQQKQK 10 1 P84101-4;P84101 P84101-4 SERF2 Small EDRK-rich factor 2 1 5213570.0 1690000.0 3085600.0 437970.0 True False 2314838.670532749 2949267.9892853047 334530.5062752872 1.0 1.2740706412194784 0.14451568937989817 21.142480219685396 -6.842578721811835 1.2701914852855876 1.1457947562101358 0.10538564490055934 0.9288232792966533 0.12834472804526345 0.1658084658696666 0.5185012528893647 0.07919137292890416 0.18260553562921647 1.4368825751399464e-07 6.842578721811835 -1.0404091113095766 down DSEK(ub)HIEVEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSEKHIEVEVR 11 1 Q9H8H0;J3QR28 Q9H8H0 NOL11 Nucleolar protein 11 1 10959000.0 3308700.0 4208500.0 3441800.0 True False 4283177.374227621 3974293.275431181 2815427.715850255 1.0 0.9278843550456183 0.6573222329738229 22.030249992436836 -6.946348458577798 0.5975966238939175 1.0030643134603858 0.5683493156392201 0.9988826131931573 0.0049308602107017985 0.08498616680764798 0.04229330520959944 0.005072812050469117 0.02271969041750662 1.1314921399533142e-07 6.946348458577798 -0.43471499782116574 DSEK(ub)NMSIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSEKNMSIK 9 1 P62195;P62195-2 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 9914700.0 1725200.0 2968700.0 5220800.0 True False 2261753.906860567 2525781.531901966 4680601.697449856 1.0 1.116735788204245 2.0694566651359416 21.1090105328401 -6.929725711279095 0.7490383198979478 0.9853642387635937 2.263687538885479 0.9964841574911781 0.028402585363166196 0.09278018266246017 0.07837896493281775 0.025834179074166356 0.08633494252206622 1.1756398230275172e-07 6.929725711279095 1.2783233001218852 up DSEK(ub)NMSIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSEKNMSIK 9 1 P62195;P62195-2 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 15134800.0 2733200.0 5749500.0 6652100.0 True False 2646436.06207804 8045305.333246416 4909715.451277633 1.0 3.0400527896861655 1.8552178613461063 21.335619368191267 -10.452992757906209 6.011521380654506 0.9992547304404943 2.4476353255161354 0.6655970990753621 0.48370683397670394 0.004833468137912071 0.00043981023147639394 0.46853797280265713 0.15611570936987412 3.5237674706505004e-11 10.452992757906209 1.448380595075641 DSEK(ub)NMSIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSEKNMSIK 9 1 P62195;P62195-2 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 16304900.0 1601100.0 5549000.0 9154800.0 True False 2428985.7560890396 4558737.595465119 7345349.767308614 1.0 1.8768070516828543 3.0240398688609496 21.211922599157994 -6.967428441698464 0.31359006189145744 0.830587378419065 4.10691722227713 0.9999548089733407 0.005571313080852725 0.07714629730912136 0.012002685489433751 0.01786471190544052 0.10150433343246017 1.0778828408257876e-07 6.967428441698464 3.2763298438580652 DSEK(ub)NMSIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSEKNMSIK 9 1 P62195;P62195-2 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 6839300.0 1725200.0 1608800.0 3505300.0 True False 2363053.061776986 1537717.8964098366 2677420.333919598 1.0 0.6507335452101496 1.1330343686426625 21.17222059436299 -6.712434594986562 1.7863250968638484 0.7858172094802106 1.131994489022751 0.47673943506397676 0.14712410993214736 0.3702083081144753 2.304206103570286 0.06550281538108943 0.16593104645591897 1.9389446202056732e-07 6.712434594986562 0.3461772795425403 DSEK(ub)NMSIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSEKNMSIK 9 1 P62195;P62195-2 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 14479700.0 2733200.0 7718600.0 4027900.0 True False 2272776.9012901806 7677018.3697778545 4870115.267094608 1.0 3.377814322831187 2.142803926038673 21.116024643625543 -9.918980755412797 10.154234459066938 1.00000312849938 2.7603091244352154 0.7303703060451003 0.5041908831988763 0.0 0.0 0.4881807234832523 0.16272690782775073 1.205089339468544e-10 9.918980755412797 1.7603059959358354 DSEK(ub)NMSIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSEKNMSIK 9 1 P62195;P62195-2 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 9575300.0 1601100.0 3864300.0 4109900.0 True False 2072655.5123993827 3649248.3080072957 3361940.371135149 1.0 1.760663210155358 1.6220449327072413 20.983048921250443 -10.085926349768856 4.4256126616186995 0.9999421628155627 1.6913540713771544 0.9707315082153349 0.05659067501905915 8314289.070400709 6316062.78362259 4448.936477295848 0.019372493067942743 8.204906762018067e-11 10.085926349768856 0.6914119085615917 DSESSPNDFSVSLK(ub)AQGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSESSPNDFSVSLKAQGK 18 1 C9JAB9;P16333-2;P16333 C9JAB9 NCK1 Cytoplasmic protein NCK1 1 11145600.0 2224500.0 3930400.0 4990700.0 True False 2879659.1014505224 3711669.784900729 4082443.80890635 1.0 1.2889267979779662 1.417683019094159 21.45746660260412 -12.635543140377502 0.12360100867128446 4.782320309647259e-18 1.6284718557466364 0.9997135870358842 0.002955684370659731 7.288595002327592 0.09521804604093204 1.9867801221274335 0.1702954143617853 2.314498265322246e-13 12.635543140377502 1.6284718557466364 DSETGENIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSETGENIR 9 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 2311860.0 674490.0 346670.0 1290700.0 False True 653078.6841471605 485097.138860167 952626.9498299849 1.0 0.7427851354445039 1.4586710192111034 19.316897295290058 -6.809521120883241 1.4164444603193669 0.8597397520903161 1.47107063774033 0.85859754891694 0.11134079009280459 0.207454537877301 0.8204073167569627 0.061808361198990025 0.14301342831026792 1.550525378832163e-07 6.809521120883241 0.6113308856500139 DSETSFVPTNMAVNYVQHNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSETSFVPTNMAVNYVQHNR 20 0 Q9NZ63 Q9NZ63 C9orf78 Uncharacterized protein C9orf78 0 12252700.0 3037300.0 5015400.0 4200000.0 False True 3981929.7132550357 4267121.869876082 3765424.28924483 1.0 1.0716215948442533 0.9456280146559335 21.925036324979942 -6.7525008020381305 1.6405811181936558 1.0419870008781302 0.9453288163749989 0.6596767510306107 0.030100319749915096 0.2956973302203685 1.5666097605399534 0.014489073536491747 0.03508380448199337 1.768068952530441e-07 6.7525008020381305 -0.09665818450313135 DSFALK(ub)SNER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSFALKSNER 10 1 O95235-2;O95235;D6RBN1;D6R9E4 O95235-2 KIF20A Kinesin-like protein KIF20A;Kinesin-like protein 1 3291850.0 1007600.0 1645300.0 638950.0 True False 1320973.3576122795 1399827.6533291673 572837.5832411865 1.0 1.0596940848674046 0.4336480973973744 20.333169938839838 -6.883518744338624 1.059944235978994 1.0390475620227133 0.38616802181536264 0.9764161270603697 0.04332305346733924 0.12456038591886627 0.25381924590474664 0.03137812318880745 0.07660872424831881 1.3076191002934883e-07 6.883518744338624 -0.6528795402073506 down DSFALK(ub)SNER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSFALKSNER 10 1 O95235-2;O95235;D6RBN1;D6R9E4 O95235-2 KIF20A Kinesin-like protein KIF20A;Kinesin-like protein 1 5408400.0 1177900.0 1524000.0 2706500.0 True False 1140508.2092498622 2132541.1475550113 1997586.456740414 1.0 1.8698165697181885 1.7514880125714056 20.1212454003683 -10.320083861670795 5.50580055052555 0.9998536637351647 1.8106522911448129 0.984271543420804 0.0483074311682854 8.678914226629294e-05 1.071758124677119e-05 0.04678174905548142 0.01559115636772778 4.7853767842886095e-11 10.320083861670795 0.8107986274096481 DSFALK(ub)SNER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSFALKSNER 10 1 O95235-2;O95235;D6RBN1;D6R9E4 O95235-2 KIF20A Kinesin-like protein KIF20A;Kinesin-like protein 1 16728200.0 2671700.0 3649500.0 10407000.0 True False 4053164.2274330663 2998218.211326357 8350051.888449857 1.0 0.7397228543155224 2.0601316452795397 21.950617201482476 -6.855511390480237 1.208169280784152 0.860145246690863 2.1188143580985237 0.9479531102579735 0.13028301028754372 0.15149585722551254 0.4227742812866269 0.08424508065621102 0.19576793407942694 1.3947250769385975e-07 6.855511390480237 1.2586691114076607 up DSFALK(ub)SNER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSFALKSNER 10 1 O95235-2;O95235;D6RBN1;D6R9E4 O95235-2 KIF20A Kinesin-like protein KIF20A;Kinesin-like protein 1 2921140.0 1007600.0 1090800.0 822740.0 True False 1380136.9493661535 1042604.8492067705 628425.7568621829 1.0 0.7554357918506572 0.4553357963141237 20.39638000036273 -6.968379414959677 0.29433113379671794 1.0556813196510022 0.14576197260037488 0.9999668380577407 0.0012826849916964696 0.07683211633602897 0.010902405421614495 0.005124211197418122 0.027080911116366693 1.0755251863753634e-07 6.968379414959677 -0.9099193470506273 down DSFALK(ub)SNER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSFALKSNER 10 1 O95235-2;O95235;D6RBN1;D6R9E4 O95235-2 KIF20A Kinesin-like protein KIF20A;Kinesin-like protein 1 5754100.0 1177900.0 2687200.0 1889000.0 True False 979476.0398176876 2672723.5202325652 2283981.1662508324 1.0 2.7287278213870816 2.3318397524823125 19.901650675802575 -10.134148399649492 5.179932587611133 0.9999499156764834 2.5302837869362715 0.9519737823277249 0.16202887564138355 9.372421345222707e-05 1.5666409107367312e-05 0.1568888628995006 0.05229459474619037 7.342629255728398e-11 10.134148399649492 1.530333871259788 DSGK(ub)SEESSHYSTEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSGKSEESSHYSTEK 15 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 27224200.0 8887900.0 12361000.0 5975300.0 True False 11652122.970546046 10516786.982800618 5357033.275124911 1.0 0.9025640228295476 0.4597474029982596 23.474089496348334 -6.941955487885385 0.641113876029072 1.0048515159278248 0.3331357576802453 0.9984089701391268 0.009377648315199133 0.08688576734954191 0.05063148534637463 0.009269838708310633 0.03779615549474414 1.1429954777437931e-07 6.941955487885385 -0.6717157582475796 down DSGK(ub)SEESSHYSTEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSGKSEESSHYSTEK 15 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 21512400.0 7882700.0 9146600.0 4483100.0 True False 7632468.003271821 12798885.078888891 3308841.619882858 1.0 1.6768999324205978 0.43352184620550677 22.86371820572245 -6.758857765135821 1.6166478121409138 1.3937372223562825 0.4292144274559229 0.6863362340789699 0.28466225104781123 0.2848395568526559 1.4669421699152836 0.138943885304596 0.33429798131683347 1.7423774222890678e-07 6.758857765135821 -0.9645227949003596 DSGK(ub)SEESSHYSTEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSGKSEESSHYSTEK 15 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 22348800.0 7370000.0 4563800.0 10415000.0 True False 11180828.819171969 3749354.2328678505 8356470.6849433305 1.0 0.3353377726737722 0.7473927756244992 23.414523801318317 -10.880155856496156 9.759550389786567 1.0310343011293153 0.5413652741494717 0.6229002292046635 0.16822075053171634 0.08160832831074566 0.0010021222975086085 0.11701628670455763 0.05429301377465415 1.3177837368894063e-11 10.880155856496156 -0.4896690269798436 DSGK(ub)SEESSHYSTEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSGKSEESSHYSTEK 15 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 23117400.0 8887900.0 7347400.0 6882100.0 True False 12173996.81646631 7022767.573397348 5256689.72129862 1.0 0.5768662239091841 0.43179654147670915 23.537299557871226 -13.999999999999998 0.14938672670093486 3.0441205041990558 0.27106023226318215 0.9995682995994921 0.005008373204708932 11.955461305371227 0.12169342957692927 7.095164280330759 0.1447933033391805 1.0000000000000041e-14 13.999999999999998 -2.7730602719358735 DSGK(ub)SEESSHYSTEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSGKSEESSHYSTEK 15 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 23714700.0 7370000.0 4540700.0 11804000.0 True False 9540610.284419129 4288006.053403912 9655793.11926794 1.0 0.4494477738396568 1.0120729000991602 23.185650123410767 -10.803129747615454 11.892600932918612 1.0012269862365952 0.7307603369694086 0.2339139490145692 0.22969074596745734 0.007498033140743676 0.00012412213865035663 0.22315888040931942 0.0741323694924934 1.573512699568822e-11 10.803129747615454 -0.27046664926718667 DSGYLHLLYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSGYLHLLYK 10 0 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A0A0MSW3;A0A494BZU9 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 0 10504000.0 5365300.0 5138700.0 0.0 False True 7033960.257639113 4372025.990495718 0.0 1.0 0.6215596662985909 0.0 22.745905752983877 -7.599569469323125 0.6782829506960889 0.9964312144605012 5.0576924578789186e-21 0.9871265383380178 0.04677445659720431 0.12116620770730759 0.14655821719802803 0.042311928572976776 0.07711076704879913 2.5143777834004633e-08 7.599569469323125 -0.9964312144605012 down DSGYLHLLYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSGYLHLLYK 10 0 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A0A0MSW3;A0A494BZU9 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 0 17951400.0 5365300.0 5811200.0 6774900.0 False True 7348996.4017806975 5554441.968931414 5174808.153445318 1.0 0.7558095915770956 0.7041516787505077 22.809115814506768 -13.999999999999998 0.21831645678926911 2.462767963978261 0.6760700222344956 0.9994962612383466 0.002895815327571665 12.954318400766715 0.14803250081072414 8.162105331465245 0.02890943769724456 1.0000000000000041e-14 13.999999999999998 -1.7866979417437654 DSGYPETLVNLIVLSQHLGK(ub)PPEVTNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSGYPETLVNLIVLSQHLGKPPEVTNR 27 1 M0QXB4;O14579-2;O14579 M0QXB4 COPE Coatomer subunit epsilon 1 41704700.0 28852400.0 10261000.0 2591300.0 True False 37350000.56583099 9689966.329856077 2119709.9889833103 1.0 0.259436845597287 0.0567526092870395 25.154604929082048 -10.21516874702075 0.3065561904631004 1.5742489851040662 1.6028382127016586e-20 0.9988659870748942 0.013652293289431752 1.7315812134503803 0.1476870138012886 0.8946040256527509 0.07020576397700626 6.093001050186545e-11 10.21516874702075 -1.5742489851040662 DSIDAGSK(ub)ELQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSIDAGSKELQVK 13 1 E7EQY1;Q96C01 E7EQY1 FAM136A Protein FAM136A 1 7516300.0 3174900.0 2057800.0 2283600.0 True False 4162324.6457753307 1750784.261241577 2047314.9778379756 1.0 0.4206265513235699 0.491868163122729 21.98895806361037 -10.466055922369359 6.1058207887745874 1.000298699524676 0.45624735722389365 0.9872892724386475 0.029084266226897082 0.00011832302769878025 1.0347192122641148e-05 0.028175689124560643 0.009386906561119564 3.419354100190146e-11 10.466055922369359 -0.5440513423007824 DSIDAGSK(ub)ELQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSIDAGSKELQVK 13 1 E7EQY1;Q96C01 E7EQY1 FAM136A Protein FAM136A 1 11573900.0 4469300.0 2856900.0 4247700.0 True False 4327424.517871135 3997675.0685366816 3135099.94173148 1.0 0.9238000690774214 0.7244724728956761 22.045077224585015 -6.954483681267749 0.5072381403733658 1.0037533958513127 0.6358154002157606 0.9995077881996339 0.0025772609585300796 0.08173372137199354 0.02888617262597135 0.00298285091660549 0.01644816370841681 1.1104942616709881e-07 6.954483681267749 -0.3679379956355522 DSIDAGSK(ub)ELQVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSIDAGSKELQVK 13 1 E7EQY1;Q96C01 E7EQY1 FAM136A Protein FAM136A 1 22742700.0 8713500.0 5482900.0 8546300.0 True False 13219016.542178405 4504433.65690677 6857120.05902365 1.0 0.3407540676369007 0.5187314833251312 23.656111512577617 -10.797223825938543 10.71453710356103 1.0038319334263466 0.4297427754821119 0.9319187506525242 0.07265897569589642 0.00663631209802611 0.00012559412082828458 0.07019705506573776 0.023450583568558017 1.595056877711598e-11 10.797223825938543 -0.5740891579442347 DSIDAGSK(ub)ELQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSIDAGSKELQVK 13 1 E7EQY1;Q96C01 E7EQY1 FAM136A Protein FAM136A 1 8159100.0 3174900.0 2654700.0 2329500.0 True False 4348746.328446404 2537406.576081052 1779320.0775584688 1.0 0.5834800157192761 0.409157017487873 22.05216812513326 -13.999999999999998 0.11936981199187534 2.986156291102118 0.1285497827182671 0.9996960396055754 0.004321542177462896 11.966201121399711 0.10624873693561215 5.642900595682682 0.24899826266542568 1.0000000000000041e-14 13.999999999999998 -2.857606508383851 DSIDAGSK(ub)ELQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSIDAGSKELQVK 13 1 E7EQY1;Q96C01 E7EQY1 FAM136A Protein FAM136A 1 12947800.0 4469300.0 5878600.0 2599900.0 True False 3716420.973560737 5846930.814989268 3143527.0694206073 1.0 1.5732692438734328 0.8458479520442392 21.82548250001929 -6.696608156673346 1.8433020941111407 1.3571540689962656 0.848165355831096 0.4014210268592886 0.24213692960652788 0.4025782193377166 2.65696746411066 0.10490088414626145 0.27087890593002245 2.0109063398348604e-07 6.696608156673346 -0.5089887131651696 DSIDAGSK(ub)ELQVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSIDAGSKELQVK 13 1 E7EQY1;Q96C01 E7EQY1 FAM136A Protein FAM136A 1 23661000.0 8713500.0 6906400.0 8041100.0 True False 11279797.518763363 6522052.76878648 6577702.308653465 1.0 0.578206546521547 0.5831401049275747 23.427237834670066 -9.974728962604887 5.420474796471592 1.000001161707167 0.5806733257235972 0.9998961909262728 0.0020141167885490553 2.827545648705717e-08 5.3477166887570695e-09 0.0019501656125820398 0.0006500533977906982 1.0599149976268878e-10 9.974728962604887 -0.4193278359835697 DSIFEPAK(ub)GGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSIFEPAKGGEK 12 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISU1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 25509800.0 6449200.0 6054600.0 13006000.0 True False 9783907.899674868 4974109.32519428 10435358.399267692 1.0 0.5083969898530603 1.0665838748967038 23.221979392516158 -6.674242125058463 1.9233510703180268 0.6873475349181056 1.064324702416891 0.29760463437326345 0.20862287019634643 0.45140416750757956 3.223561153541329 0.08721990046145014 0.23166240471437885 2.117180449366035e-07 6.674242125058463 0.3769771674987853 DSIFEPAKGGEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSIFEPAKGGEK 12 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISU1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 8942600.0 3791300.0 2176700.0 2974600.0 True False 3670947.256752699 3045867.661340545 2195463.0239128154 1.0 0.8297225343506852 0.5980644423245979 21.80772095563089 -6.966828861495819 0.32513820346704175 1.0298721148835341 0.39038591025454633 0.999946031251163 0.0012101203059602602 0.07734572637569997 0.012700318094213925 0.0034413287015825564 0.02028691192095685 1.0793719768028313e-07 6.966828861495819 -0.6394862046289878 DSISSYEAQITALK(ub)QER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSISSYEAQITALKQER 17 1 Q9H5N1;Q9H5N1-2;H3BNR2;H3BT64 Q9H5N1 RABEP2 Rab GTPase-binding effector protein 2 1 159484500.0 43592900.0 70586100.0 45305500.0 True False 57150714.05424412 60054929.022462755 40617721.46104323 1.0 1.05081677484313 0.710712405491404 25.76826818812953 -6.868873294641584 1.1401152487811839 1.0285502490940646 0.6912225532964387 0.9635417386659578 0.028601484618324183 0.13793572255391157 0.3358201550351718 0.019482966100392303 0.046036110540720925 1.3524670877365757e-07 6.868873294641584 -0.3373276957976259 DSISSYEAQITALK(ub)QER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSISSYEAQITALKQER 17 1 Q9H5N1;Q9H5N1-2;H3BNR2;H3BT64 Q9H5N1 RABEP2 Rab GTPase-binding effector protein 2 1 459318000.0 198473000.0 117317000.0 143528000.0 True False 192172583.25362772 164162289.90007302 105933711.05229554 1.0 0.8542440712440913 0.5512425823640261 27.517827284464328 -6.959281725195543 0.44544136557219016 1.0102394894089313 0.3833262054629205 0.9997426236437236 0.0029986771968515684 0.07995871580933459 0.02208695364106755 0.004023516410046044 0.025081244808795998 1.0982931496661802e-07 6.959281725195543 -0.6269132839460108 DSISSYEAQITALK(ub)QER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSISSYEAQITALKQER 17 1 Q9H5N1;Q9H5N1-2;H3BNR2;H3BT64 Q9H5N1 RABEP2 Rab GTPase-binding effector protein 2 1 672998000.0 261750000.0 368822000.0 42426000.0 True False 397093886.48823017 303002832.48056155 34040482.50402362 1.0 0.7630508622538125 0.08572401555981289 28.564904908928778 -7.230145567792161 0.6771179244940868 0.9971274517172698 7.694719971918957e-26 0.9959870407878848 0.02454196798751156 0.09168520879872062 0.07642507920548054 0.02247033991786224 0.05868278292006243 5.886463185008467e-08 7.230145567792161 -0.9971274517172698 down DSISSYEAQITALK(ub)QER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSISSYEAQITALKQER 17 1 Q9H5N1;Q9H5N1-2;H3BNR2;H3BT64 Q9H5N1 RABEP2 Rab GTPase-binding effector protein 2 1 248514600.0 43592900.0 65983700.0 138938000.0 True False 59710373.183826745 63068321.95508323 106123705.91793028 1.0 1.0562372765770291 1.7773076981316729 25.83147824965242 -6.922459957887472 0.8062691988720748 0.9854564227769222 1.9004321671414004 0.9948374985555988 0.02542909927639338 0.09674580847337806 0.09827092182618526 0.022200198660563525 0.06814822823267701 1.1954737437157357e-07 6.922459957887472 0.9149757443644781 DSISSYEAQITALK(ub)QER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSISSYEAQITALKQER 17 1 Q9H5N1;Q9H5N1-2;H3BNR2;H3BT64 Q9H5N1 RABEP2 Rab GTPase-binding effector protein 2 1 456002000.0 198473000.0 129583000.0 127946000.0 True False 165039093.34471184 128884910.65878837 154698917.04453623 1.0 0.7809356440754955 0.9373471091568686 27.298232559898604 -10.476857207358146 5.034837444587208 1.0003272235247704 0.8591413766161764 0.5195438459744115 0.06385471322843825 0.0002350856618966551 2.4426480129207845e-05 0.06196980526045931 0.020609020075879867 3.335360587942599e-11 10.476857207358146 -0.14118584690859404 DSISSYEAQITALK(ub)QER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSISSYEAQITALKQER 17 1 Q9H5N1;Q9H5N1-2;H3BNR2;H3BT64 Q9H5N1 RABEP2 Rab GTPase-binding effector protein 2 1 678028000.0 261750000.0 380732000.0 35546000.0 True False 338840534.8638672 359543929.50967425 29076992.732759967 1.0 1.0611007022938528 0.08581320633448403 28.336031231021227 -6.893357983372439 1.012598174874761 1.049828661256996 3.7302763706093787e-16 0.982134700739778 0.0596197336449978 0.1170629905793917 0.2129569743853732 0.04481319299411962 0.11201540529409262 1.2783271610721182e-07 6.893357983372439 -1.0498286612569956 down DSITLISMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSITLISMK 9 0 Q19T08 Q19T08 ECSCR Endothelial cell-specific chemotaxis regulator 0 20892800.0 7505000.0 8085600.0 5302200.0 False True 11385633.688993951 6642661.506918858 4254217.845963185 1.0 0.5834248394395527 0.3736478761015798 23.440711253843933 -11.128819773805494 0.1251604616817246 2.037224908141411 4.0685287115808505e-23 0.9997812446381004 0.0038501003752440584 3.5123986411133155 0.07597507432225749 1.2888996057506485 0.25399152791881074 7.43327544535064e-12 11.128819773805494 -2.037224908141411 DSIVHQAGMLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSIVHQAGMLK 11 0 O15144 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 5609530.0 1791600.0 537730.0 3280200.0 False True 1734726.638672259 752448.3932249047 2421017.2161093326 1.0 0.4337561760167703 1.3956188612877665 20.726276907572327 -6.747145251390783 1.6601773252722807 0.6659129095149432 1.3971529817584647 0.6367269612093023 0.23791391801689865 0.30503179028976696 1.6531724411037398 0.11324465338331854 0.27578158263335134 1.790007079441942e-07 6.747145251390783 0.7312400722435215 DSIVHQAGMLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSIVHQAGMLKR 12 1 O15144 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 1 5310500.0 1159800.0 1365900.0 2784800.0 True False 1122982.783842423 1911310.9930743992 2055377.337790767 1.0 1.7019949197570197 1.8302839254205143 20.09890437964902 -11.207445744364101 0.3073356564411142 2.0808762284537102e-24 1.8646365506436775 0.9993199592148817 0.00951673667728556 3.2726464671595563 0.15959391287891367 2.291940495016279 0.04481103786840155 6.202321233081664e-12 11.207445744364101 1.8646365506436775 DSIVHQAGMLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSIVHQAGMLKR 12 1 O15144 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 1 18673100.0 1515200.0 3899900.0 13258000.0 True False 2298669.1759578497 3203932.3749422254 10637550.488812178 1.0 1.3938205673320323 4.627699627276525 21.132367417916907 -6.929613430184403 0.7499599335892831 0.9501107337252992 5.2851064395898675 0.9964616982088449 0.09667644441138966 0.09283906285224322 0.07866756536439923 0.08787518250223897 0.29323481094812065 1.1759438084497755e-07 6.929613430184403 4.334995705864568 up DSIVHQAGMLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSIVHQAGMLKR 12 1 O15144 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 1 3711440.0 1273700.0 755940.0 1681800.0 True False 1744621.3104482614 722540.071240709 1284593.4777582448 1.0 0.41415295509319455 0.7363165118212287 20.734482486659996 -10.151312303989002 5.514020605065569 1.0000088811162284 0.5752347334571701 0.6985993084258213 0.13152272128421577 1.4359804731711277e-05 2.2101747125466215e-06 0.12734898801708922 0.04244877576510279 7.058098192915175e-11 10.151312303989002 -0.4247741476590583 DSIVHQAGMLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSIVHQAGMLKR 12 1 O15144 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 1 4872500.0 1159800.0 1737900.0 1974800.0 True False 964425.087851731 1728537.5877538577 2387721.549556451 1.0 1.7922984475696262 2.47579784021912 19.879309655083297 -6.9728487658529765 0.17739770909080727 0.45304123925778933 3.8334905777011636 0.9999969251344982 0.0010574281647156953 0.07538871121888907 0.0055782809223103485 0.02693680446564653 0.07732051803013132 1.064513648735979e-07 6.9728487658529765 3.3804493384433743 DSIVQGFQWGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSIVQGFQWGTR 12 0 Q15029-2;Q15029;Q15029-3;K7EP67;K7EJ74 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 25227700.0 7315300.0 7499400.0 10413000.0 False True 9590429.14146597 6380518.7524322355 9335562.648549141 1.0 0.6653006511298748 0.9734249125709228 23.193163942066302 -10.427800734955538 8.346478896883177 1.0000030266217501 0.8193627823431571 0.3142460041884618 0.1257912029837482 7.084680459164549e-06 4.857920852819959e-07 0.1217988481429273 0.04059893618795448 3.73421453489554e-11 10.427800734955538 -0.18064024427859304 DSIVQGFQWGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSIVQGFQWGTR 12 0 Q15029-2;Q15029;Q15029-3;K7EP67;K7EJ74 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 19892100.0 6863200.0 1246900.0 11782000.0 False True 6645331.472725748 1744793.6724975996 8695940.747576404 1.0 0.26255931395728094 1.308578929925003 22.66390973302888 -6.717289210032376 1.7693700705318893 0.5500558522992277 1.3066752165804405 0.49961304118211547 0.3104242714640636 0.3605831001896395 2.204734890273786 0.1393949674783083 0.3510144036751784 1.9173914655704766e-07 6.717289210032376 0.7566193642812128 DSIVQGFQWGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSIVQGFQWGTR 12 0 Q15029-2;Q15029;Q15029-3;K7EP67;K7EJ74 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 13356400.0 6863200.0 2496600.0 3996600.0 False True 5707054.891312299 2483150.3202637006 4832270.581809464 1.0 0.43510188136506894 0.8467187847037363 22.444315008463157 -9.738139381315891 5.956955846291832 1.0000000109233262 0.6409103330325915 0.5036599801573023 0.16804189712052806 2.4150109278506567e-08 5.291055565194164e-09 0.16270587209938703 0.05423528908345933 1.8275136046595309e-10 9.738139381315891 -0.35908967789073476 DSK(ub)AYYHLLEQVAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSKAYYHLLEQVAPK 15 1 P13796 P13796 LCP1 Plastin-2 1 44282000.0 14536000.0 16413000.0 13333000.0 True False 19056836.76682422 13964244.377372926 11953429.059166985 1.0 0.7327682210975897 0.6272514796357254 24.183805331227074 -13.999999999999996 0.12834066951800197 2.2698125741114064 0.4763206424536003 0.9996531908124914 0.002921449340712997 11.939582416062962 0.11123874831054628 3.8303879680535817 0.1341501107337803 1.0000000000000082e-14 13.999999999999996 -1.793491931657806 DSK(ub)AYYHLLEQVAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSKAYYHLLEQVAPK 15 1 P13796 P13796 LCP1 Plastin-2 1 54650000.0 18370000.0 16893000.0 19387000.0 True False 17786854.40522964 23638462.99583121 14308963.102466807 1.0 1.3289850165345198 0.8044684448678979 24.084308057602705 -6.737117612971175 1.6973262202211863 1.196383187995636 0.8043499316084166 0.5920519633501709 0.13823622679996125 0.32298002096537387 1.8258668279245103 0.06446187126586175 0.15868220765107344 1.8318182733888387e-07 6.737117612971175 -0.3920332563872193 DSK(ub)AYYHLLEQVAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSKAYYHLLEQVAPK 15 1 P13796 P13796 LCP1 Plastin-2 1 75352000.0 36646000.0 23819000.0 14887000.0 True False 55594661.18146201 19568313.351303574 11944577.924796117 1.0 0.3519818798325298 0.21485116863665726 25.72844301016667 -13.999999999999957 0.2182710764625562 4.881043084567747 0.14027333656063784 0.9994962206459286 0.007685362293714206 12.953175952232032 0.14801819502178093 21.64892660373564 0.07676637030970455 1.0000000000000981e-14 13.999999999999957 -4.740769748007109 DSK(ub)AYYHLLEQVAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSKAYYHLLEQVAPK 15 1 P13796 P13796 LCP1 Plastin-2 1 40900000.0 14536000.0 13170000.0 13194000.0 True False 19910352.02062961 12588105.852633985 10077848.938959625 1.0 0.6322392411541059 0.5061612636741789 24.247015392749965 -13.999999999402903 0.14939516935719718 2.776640975294246 0.36648121477982337 0.999568270839754 0.0043530512329303115 11.955513286582242 0.12169755180600263 6.167099154193302 0.12582682753171326 1.0000000013748678e-14 13.999999999402903 -2.4101597605144223 DSK(ub)AYYHLLEQVAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSKAYYHLLEQVAPK 15 1 P13796 P13796 LCP1 Plastin-2 1 50903000.0 18370000.0 20270000.0 12263000.0 True False 15275468.928984584 20160801.486720026 14827136.602294303 1.0 1.3198155539739747 0.9706501758620589 23.86471333303698 -6.665880266760746 1.9531011588071399 1.2048663930394223 0.972117178294619 0.2605430019145252 0.135982878773289 0.47058864233432773 3.457051066622703 0.05614640456753064 0.15075802996677826 2.1583393726052778e-07 6.665880266760746 -0.23274921474480337 DSK(ub)AYYHLLEQVAPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSKAYYHLLEQVAPK 15 1 P13796 P13796 LCP1 Plastin-2 1 75027500.0 36646000.0 30082000.0 8299500.0 True False 47438969.40065435 28407910.2557968 6789076.160061353 1.0 0.5988306789692812 0.1431117970275237 25.49956933225912 -7.625557283813879 0.4368304347275139 1.0310190619997721 3.869318797195615e-15 0.997837690709393 0.016277981772734245 0.11930667162674656 0.0669261599238221 0.024787215711626506 0.07300967341152957 2.368332726067661e-08 7.625557283813879 -1.0310190619997683 down DSK(ub)VVEIVDEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSKVVEIVDEK 11 1 Q6PKG0-3;Q6PKG0;A0A0B4J210;E5RH50;H0YBW1;H0YC73 Q6PKG0-3 LARP1 La-related protein 1 1 7961000.0 2548200.0 2933900.0 2478900.0 True False 3340714.8768039043 2496173.5562526253 2222407.2072878573 1.0 0.7471974257919131 0.6652489928784514 21.671725426174156 -13.999999999999998 0.15754853275629535 2.238785034144622 0.5824701827164601 0.9995430311608016 0.0030455815689265425 11.994273960220317 0.12534678402918886 4.541542224246983 0.07522039169042742 1.0000000000000041e-14 13.999999999999998 -1.6563148514281618 DSK(ub)VVEIVDEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSKVVEIVDEK 11 1 Q6PKG0-3;Q6PKG0;A0A0B4J210;E5RH50;H0YBW1;H0YC73 Q6PKG0-3 LARP1 La-related protein 1 1 11483400.0 3536600.0 4294500.0 3652300.0 True False 3424332.568836968 6009316.245521653 2695653.063348612 1.0 1.7548868647307359 0.7872053923384424 21.70739139142316 -6.69855158278104 1.835769572956695 1.4694287249691274 0.7901424830915472 0.4106980895343145 0.31873488559272656 0.3986131489657806 2.610574335944541 0.13855850217171578 0.35700953084963666 2.0019278310066235e-07 6.69855158278104 -0.6792862418775801 DSK(ub)VVEIVDEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSKVVEIVDEK 11 1 Q6PKG0-3;Q6PKG0;A0A0B4J210;E5RH50;H0YBW1;H0YC73 Q6PKG0-3 LARP1 La-related protein 1 1 34707300.0 5760800.0 7634500.0 21312000.0 True False 8739554.77089359 6272063.826379243 17099673.85861858 1.0 0.7176639990023137 1.9565840946003012 23.059128354063198 -6.8467893219467895 1.2504408370849849 0.8496470760835375 2.0031374290008004 0.9355030064019156 0.13464248272139415 0.1610293375862244 0.48613346886486836 0.08431987684436013 0.19476773658818872 1.4230189320952004e-07 6.8467893219467895 1.1534903529172629 DSK(ub)VVEIVDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSKVVEIVDEK 11 1 Q6PKG0-3;Q6PKG0;A0A0B4J210;E5RH50;H0YBW1;H0YC73 Q6PKG0-3 LARP1 La-related protein 1 1 8277300.0 2548200.0 1819900.0 3909200.0 True False 3490338.402515716 1739490.8003954892 2985927.472501212 1.0 0.49837310879132063 0.8554836603663009 21.734935487697047 -10.047409784527622 5.571098033972265 1.000001593401885 0.6769283845786662 0.521820956394867 0.14578977218761033 2.8853282169165197e-06 4.931050709789064e-07 0.14116103611702402 0.047053446644090516 8.965824125972951e-11 10.047409784527622 -0.3230732088232189 DSK(ub)VVEIVDEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSKVVEIVDEK 11 1 Q6PKG0-3;Q6PKG0;A0A0B4J210;E5RH50;H0YBW1;H0YC73 Q6PKG0-3 LARP1 La-related protein 1 1 9150500.0 3536600.0 3686000.0 1927900.0 True False 2940839.5979448473 3666142.7863862864 2331014.976397551 1.0 1.2466313324087122 0.7926358778719311 21.487796666857438 -6.759188818971467 1.6156527241869 1.143402065335638 0.7910506829627311 0.6876045882400177 0.10372155472027787 0.2842788607054363 1.4623714787207898 0.0506585542774434 0.12183193003572691 1.7410497495708457e-07 6.759188818971467 -0.352351382372907 DSK(ub)VVEIVDEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSKVVEIVDEK 11 1 Q6PKG0-3;Q6PKG0;A0A0B4J210;E5RH50;H0YBW1;H0YC73 Q6PKG0-3 LARP1 La-related protein 1 1 30975600.0 5760800.0 7246800.0 17968000.0 True False 7457469.16234486 6843509.209550836 14698008.367248936 1.0 0.9176718080318584 1.9709110486790702 22.830254676155647 -6.888006728858851 1.0340594996956298 0.940674844949688 2.0580531973666725 0.9795930845054834 0.06832351356629716 0.12077705551902307 0.23139260219966207 0.0504694286001775 0.12495617321986134 1.2941757896325146e-07 6.888006728858851 1.1173783524169845 DSLAEK(ub)LQLIDDQFADAYPQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSLAEKLQLIDDQFADAYPQR 21 1 O75665;O75665-3;A6NF31;O75665-2;A0A0A0MS89 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 32459500.0 11605000.0 2228500.0 18626000.0 True False 11236605.627255842 3118351.671473975 13747291.831977453 1.0 0.2775172302843849 1.2234381349677002 23.421702953835837 -6.702592016179622 1.8217255418973177 0.5525036094771663 1.2207540720196828 0.4298111680969863 0.30482785149848857 0.39017164399397586 2.5191680799078195 0.13340450086729555 0.3419750598995702 1.9833893815242967e-07 6.702592016179622 0.6682504625425165 DSLAEK(ub)LQLIDDQFADAYPQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSLAEKLQLIDDQFADAYPQR 21 1 O75665;O75665-3;A6NF31;O75665-2;A0A0A0MS89 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 206324000.0 20578000.0 32671000.0 153075000.0 True False 31218330.453313522 26840604.790311918 122819659.15484393 1.0 0.8597706668026844 3.9342161278777743 24.895890048704462 -6.896211703597334 0.9848850879779946 0.858553755498326 4.233236036993625 0.9845861482667779 0.17597525485953808 0.11424855841269606 0.19355285303952702 0.13490222032488 0.34478252144425103 1.2699548950409642e-07 6.896211703597334 3.374682281495299 up DSLAEK(ub)LQLIDDQFADAYPQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSLAEKLQLIDDQFADAYPQR 21 1 O75665;O75665-3;A6NF31;O75665-2;A0A0A0MS89 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 32744600.0 11605000.0 5176600.0 15963000.0 True False 9650071.688669896 5148712.628325346 19300789.495427206 1.0 0.533541386471815 2.0000669547448204 23.202108229270113 -6.821152493065698 1.3668568433962152 0.7488682822135617 2.0328867514917284 0.8870155068692328 0.20563685303771595 0.19199030007654136 0.7044965712318988 0.11821322650422134 0.2723854242276119 1.5095500154261584e-07 6.821152493065698 1.2840184692781667 up DSLAEK(ub)LQLIDDQFADAYPQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSLAEKLQLIDDQFADAYPQR 21 1 O75665;O75665-3;A6NF31;O75665-2;A0A0A0MS89 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 189368000.0 20578000.0 29796000.0 138994000.0 True False 26638626.65302262 28137826.40721096 113698518.19887564 1.0 1.0562791683563848 4.268182428465191 24.66701637079691 -6.910701993005382 0.8909507329185583 0.9027476717182591 4.689546358494718 0.9911835686273056 0.14343001473306224 0.10395537545213188 0.13626651588949626 0.1178372105260827 0.3268838069191294 1.2282817723806237e-07 6.910701993005382 3.7867986867764594 up DSLAWLSLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSLAWLSLVK 10 0 G3V158;Q9Y315;E9PPM8 G3V158 DERA Deoxyribose-phosphate aldolase 0 4409810.0 905710.0 1857600.0 1646500.0 False True 1187394.5809081178 1580453.3208680856 1476135.9743432414 1.0 1.3310262201629361 1.2431722344684228 20.17936800331329 -10.112716647376036 4.424247247265056 0.9999664783145114 1.2870992272749389 0.9343789447059483 0.03586623952436021 24997436.325263277 0.5347345668280596 8678.066081726945 0.012277967767181822 7.71406604159304e-11 10.112716647376036 0.2871327489604275 DSLAWLSLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSLAWLSLVK 10 0 G3V158;Q9Y315;E9PPM8 G3V158 DERA Deoxyribose-phosphate aldolase 0 4184510.0 905710.0 1686400.0 1592400.0 False True 1240575.462892438 1611889.271820954 1216307.9165074502 1.0 1.2993077164873041 0.9804384762468158 20.24257806483618 -6.660458986369055 1.9713974011704412 1.1925915075229527 0.9817713598405261 0.23747348800845536 0.12742521284262048 0.48337515014801097 3.6118514227387553 0.052214282930666135 0.14125203355760022 2.1854506981358133e-07 6.660458986369055 -0.21082014768242663 DSLAWLSLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSLAWLSLVK 10 0 G3V158;Q9Y315;E9PPM8 G3V158 DERA Deoxyribose-phosphate aldolase 0 1868460.0 1161300.0 0.0 707160.0 False True 965672.4043129986 0.0 855023.8864615862 1.0 0.0 0.8854181631811978 19.881174325164373 -9.113343852175786 10.19438584224174 0.9999032364813156 0.4427089642552102 0.34563923552478537 0.3614704557825778 0.0 0.0 0.34999226189683585 0.11666408729894526 7.702933486582452e-10 9.113343852175786 -0.5571942722261054 DSLDQFSSSGK(ub)GAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSLDQFSSSGKGAR 14 1 X6R3U4;Q7Z736-4;Q7Z736-3;Q7Z736-2;Q7Z736;K7EK04 X6R3U4 PLEKHH3 Pleckstrin homology domain-containing family H member 3 1 8500700.0 3008020.0 2399970.0 3092710.0 True False 3943543.3497071182 2041903.8310097887 2772706.036569138 1.0 0.5177840459548742 0.7031001793793045 21.911061071025948 -10.11360093060881 5.187563235735373 1.0000098247334668 0.6104421126665948 0.8549023914834117 0.07565499466762292 8.596750501449766e-06 1.4687817944016093e-06 0.07325448058624355 0.02441754453351121 7.698375123152491e-11 10.11360093060881 -0.389567712066872 DSLDQFSSSGK(ub)GAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSLDQFSSSGKGAR 14 1 X6R3U4;Q7Z736-4;Q7Z736-3;Q7Z736-2;Q7Z736;K7EK04 X6R3U4 PLEKHH3 Pleckstrin homology domain-containing family H member 3 1 16907050.0 2964250.0 4313600.0 9629200.0 True False 2870151.5062984135 6036042.975126834 7107023.6501920475 1.0 2.1030398436741122 2.4761841437972927 21.452695463582724 -10.135729253885485 0.25544449925528206 4.41458341248866e-13 2.6702830055208073 0.9990899497571495 0.01890642370554229 1.6257810829553236 0.11854802926037775 1.291697507264448 0.16329390825113493 7.315950293695615e-11 10.135729253885485 2.670283005520366 DSLDQFSSSGK(ub)GAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSLDQFSSSGKGAR 14 1 X6R3U4;Q7Z736-4;Q7Z736-3;Q7Z736-2;Q7Z736;K7EK04 X6R3U4 PLEKHH3 Pleckstrin homology domain-containing family H member 3 1 40105600.0 4784200.0 3861400.0 31460000.0 True False 7257981.171870078 3172303.0007441 25241917.210592188 1.0 0.4370778768397839 3.477815195831984 22.791136883611124 -6.8588994495300435 1.1913727535793233 0.6954560164596935 3.621935979061296 0.9522823953137284 0.2885379346188201 0.147935800583824 0.39963459612745145 0.1889867203854593 0.4405936098991532 1.3838867476649353e-07 6.8588994495300435 2.9264799626016025 up DSLDQFSSSGK(ub)GAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSLDQFSSSGKGAR 14 1 X6R3U4;Q7Z736-4;Q7Z736-3;Q7Z736-2;Q7Z736;K7EK04 X6R3U4 PLEKHH3 Pleckstrin homology domain-containing family H member 3 1 9362550.0 3008020.0 2728610.0 3625920.0 True False 4120166.282683982 2608050.987893364 2769552.3741664765 1.0 0.6329965367791934 0.6721943203618275 21.97427113254884 -10.043619651823622 7.453770491260598 1.0000000258342552 0.6525954288733732 0.9905422832627967 0.016002428137582913 6.8734160486520455e-09 8.982840344971688e-10 0.015494285573345971 0.00516476147297829 9.044412221598305e-11 10.043619651823622 -0.347404596960882 DSLDQFSSSGK(ub)GAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSLDQFSSSGKGAR 14 1 X6R3U4;Q7Z736-4;Q7Z736-3;Q7Z736-2;Q7Z736;K7EK04 X6R3U4 PLEKHH3 Pleckstrin homology domain-containing family H member 3 1 15541050.0 2964250.0 6062900.0 6513900.0 True False 2464905.2135406896 6030237.954308575 7875926.373129315 1.0 2.446438070389935 3.1952248426689054 21.233100739017 -9.048222253311605 0.22796114600511044 1.8577309264682328e-21 3.8095011622539783 0.9993462986999733 0.02329610195983644 0.5083210917476222 0.07806541319775115 0.7422191755391497 0.351243939513449 8.949066734440237e-10 9.048222253311605 3.8095011622539783 DSLDQFSSSGK(ub)GAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSLDQFSSSGKGAR 14 1 X6R3U4;Q7Z736-4;Q7Z736-3;Q7Z736-2;Q7Z736;K7EK04 X6R3U4 PLEKHH3 Pleckstrin homology domain-containing family H member 3 1 29726200.0 4784200.0 2078000.0 22864000.0 True False 6193241.210680861 1962357.473291196 18702986.60445122 1.0 0.31685468182749205 3.0199028211909553 22.562263205703573 -6.839713700201073 1.2835881071854556 0.636545497164947 3.1083772928784286 0.9239763333891249 0.3164246445947035 0.1691387444112586 0.5414272083384578 0.1933005947552527 0.4453271988434979 1.4463929616501773e-07 6.839713700201073 2.4718317957134817 up DSLK(ub)AEAEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSLKAEAEAK 10 1 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4;K7ES92 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 1 2295490.0 470220.0 746170.0 1079100.0 True False 455293.1234854147 1044119.5722251456 796451.3376939151 1.0 2.2932908896845965 1.7493155433511163 18.7964361442301 -9.964280133627526 5.568685142740521 0.9999982559658889 2.021303216519219 0.8245586864694042 0.22207700519993534 4.808318454385823e-06 8.941475106404776e-07 0.21502550083622382 0.07167504522554956 1.085725070814968e-10 9.964280133627526 1.0213049605533302 DSLK(ub)AEAEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSLKAEAEAK 10 1 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4;K7ES92 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 1 6674300.0 0.0 1478900.0 5195400.0 True False 0.0 1214978.74030156 4168526.912775283 0.0 DSLLGDK(ub)GQTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSLLGDKGQTAR 12 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 35195900.0 11052000.0 9710900.0 14433000.0 True False 14489279.027720254 8262071.572791731 12939611.611112067 1.0 0.5702196470221257 0.8930473066573271 23.788482473805452 -10.315026468330148 5.858343500461442 1.000026056545839 0.7316334768397266 0.47954945827305195 0.1317938401605238 4.485717339555882e-05 5.244983760537865e-06 0.12762121038487226 0.042536279006202146 4.841428603163363e-11 10.315026468330148 -0.2683925797061124 DSLLGDK(ub)GQTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSLLGDKGQTAR 12 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 51092200.0 9169800.0 8947400.0 32975000.0 True False 8878709.718294742 12520143.480074598 24337858.271204565 1.0 1.4101309624163763 2.741148099600099 23.08191860420257 -6.949671146124463 0.5624408326157616 0.982809380972101 3.2323483854676933 0.9991752339773663 0.021344399097140476 0.08361803830840557 0.0365107178805766 0.022813111596677874 0.11070326750367536 1.1228683841680574e-07 6.949671146124463 2.2495390044955923 up DSLLGDK(ub)GQTAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSLLGDKGQTAR 12 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 395571000.0 19242000.0 24059000.0 352270000.0 True False 29191520.77863051 19765483.476175 282643680.09457386 1.0 0.6770967373047659 9.682389699322606 24.799046036498687 -6.898584475976052 0.9701943955145628 0.6109124824600679 10.6008685141618 0.9858481879502102 0.4962010880339763 0.11245400861233003 0.1833637828859362 0.38459299748773473 0.9937021950078386 1.263035402951204e-07 6.898584475976052 9.989956031701732 up DSLLGDK(ub)GQTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSLLGDKGQTAR 12 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 50572600.0 11052000.0 7568600.0 31952000.0 True False 15138223.069069812 7234194.225986754 24405595.672096226 1.0 0.47787604879251316 1.6121836467029853 23.851692535328343 -6.781567962713643 1.529977861806278 0.7049607835835863 1.6215800383568348 0.7728266857422065 0.22094779667327305 0.2481470266375183 1.1474577064438423 0.11373582315285756 0.2679948726216889 1.65360599183453e-07 6.781567962713643 0.9166192547732486 DSLLGDK(ub)GQTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSLLGDKGQTAR 12 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 66970800.0 9169800.0 20072000.0 37729000.0 True False 7625094.9910181025 19963868.15201994 45617959.46081395 1.0 2.6181795997998925 5.982608677603246 22.862323879636847 -6.959278656854197 0.44548313434249076 0.8863530610528946 7.846810952723816 0.9997425041635842 0.033302718858811656 0.07995980799117616 0.022091020318279756 0.0446783852075089 0.27849197352975874 1.0983009092632405e-07 6.959278656854197 6.960457891670921 DSLLGDK(ub)GQTAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSLLGDKGQTAR 12 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 478996000.0 19242000.0 20264000.0 439490000.0 True False 24909148.316525474 19136290.58651237 359507329.54820967 1.0 0.7682434719703676 14.432742740935135 24.570172358591137 -6.903045254051856 0.941839203613131 0.4783690551822457 15.95904417053841 0.9880207594062841 0.6991190383270515 0.10919755575891218 0.16505746208746347 0.553384103031669 1.4630651471312788 1.2501287583822985e-07 6.903045254051856 15.480675115356165 up DSLLQDGEFSMDLR ddPTM_RPMI8226_Bortezomib_1h_R1 2 DSLLQDGEFSMDLR 14 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 36623500.0 7259500.0 17942400.0 11421600.0 False True 9517274.801098006 15265463.858927406 10239802.395723512 1.0 1.60397426552885 1.0759174879075835 23.18211709729186 -10.082452064346246 4.735672135992729 0.9999846466346268 1.339945876723773 0.3559118027905114 0.21557827675081687 27074840.129050713 57643514.313562885 2663.045289210807 0.0737981773603954 8.270807933349514e-11 10.082452064346246 0.33996123008914625 DSLLQDGEFSMDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSLLQDGEFSMDLR 14 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 66700800.0 27947000.0 6575800.0 32178000.0 False True 27059837.782414347 9201551.232343981 23749616.480692036 1.0 0.3400445821712903 0.8776703198171588 24.689649854922592 -10.200244715696494 7.662661004651569 1.000000291126294 0.6088574509943068 0.4137464286694694 0.21948478830329915 1.091718970789711e-06 1.1364855143379515e-07 0.2125153907917295 0.07083841082037814 6.306019135949257e-11 10.200244715696494 -0.3911428401319872 DSLLQDGEFSMDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSLLQDGEFSMDLR 14 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 131107000.0 12473000.0 99486000.0 19148000.0 False True 18922452.898443922 81731946.01233417 15363389.407133445 1.0 4.319310316214625 0.8119132064742434 24.17359578011117 -6.658639517816339 1.9778353256569159 3.1390072831813223 0.8266047019021184 0.22979158843203418 1.4137515960429712 0.487675554987435 3.665878767804125 0.5778032124328479 1.5668724324311352 2.194625808732896e-07 6.658639517816339 -2.312402581279204 DSLLQDGEFSMDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DSLLQDGEFSMDLR 14 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 37498000.0 7259500.0 15990600.0 14247900.0 False True 9943533.330610957 15284082.418157108 10882839.464711456 1.0 1.5370876639097073 1.0944640202702258 23.245327158814753 -13.100583206427192 11.700948468048965 1.0496052802982334 1.2842001098711917 0.0 0.24543947056619775 0.0 0.0 0.0 0.06750480273365257 7.932622611966288e-14 13.100583206427192 0.2345948295729583 DSLLQDGEFSMDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DSLLQDGEFSMDLR 14 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 62929600.0 45053300.0 7398100.0 10478200.0 False True 37463815.14960375 7358244.966892124 12669143.174277093 1.0 0.19640938696468963 0.3381701282607117 25.158994488969952 -9.801360794061372 6.146360775575751 1.000000031453104 0.2672897579849904 0.9726923581784842 0.05787358029152633 2.4961310469758296e-08 4.890695167850419e-09 0.05603585566748968 0.018678617720834442 1.5799349486937156e-10 9.801360794061372 -0.7327102734681135 DSLLQDGEFSMDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSLLQDGEFSMDLR 14 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 48186000.0 12473000.0 21069000.0 14644000.0 False True 16146544.379587458 19896491.628860507 11978942.260128736 1.0 1.232244569557171 0.74188891310221 23.94472210220362 -6.777903059718062 1.543863975605388 1.13186331647082 0.7382461333547797 0.7599290381823385 0.09813110723473945 0.25386319528134976 1.1949861177742989 0.05006822916125106 0.11835745772145048 1.667619405754446e-07 6.777903059718062 -0.3936171831160403 DSLTEK(ub)ECVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSLTEKECVK 10 1 P26358;P26358-2;K7EJL0;K7EMU8 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 5612330.0 804930.0 1576000.0 3231400.0 True False 1041997.7525423992 1488294.2145846582 2643318.356963947 1.0 1.4283084689514232 2.536779326552712 19.990920735232887 -6.954715908211536 0.5044226485863351 0.9786267580061383 3.0346313993945415 0.9995212816270155 0.014168075810129254 0.08164554695294546 0.028539549517922008 0.016480494440772476 0.09145541682218175 1.1099006143587812e-07 6.954715908211536 2.0560046413884034 up DSLVDIIGICK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSLVDIIGICK 11 0 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 0 5003200.0 0.0 1947400.0 3055800.0 False True 0.0 1656855.5109057438 2739615.1293034153 0.0 DSLVDIIGICK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSLVDIIGICK 11 0 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 0 2916300.0 0.0 2916300.0 0.0 False True 0.0 2787448.223085539 0.0 0.0 DSLVQSCPGSLSLCAGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSLVQSCPGSLSLCAGVK 18 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 6745500.0 1618400.0 2821100.0 2306000.0 False True 2121738.0726078935 2400202.8765616743 2067397.2407139488 1.0 1.131243723034819 0.9743885295760599 21.01681513666388 -6.684676145496054 1.8848801081150433 1.0826845746132692 0.9749555115027495 0.34588169418646897 0.05556760925481425 0.42818613315689263 2.944946822277583 0.02361916953696344 0.061932224425062805 2.0669208894589197e-07 6.684676145496054 -0.10772906311051966 DSLVQSCPGSLSLCAGVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSLVQSCPGSLSLCAGVK 18 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 26043400.0 4286500.0 13813000.0 7943900.0 False True 6502933.885126273 11347962.228538403 6373784.683064949 1.0 1.7450526837576867 0.9801398562029489 22.632659325397388 -10.233624818044628 4.077715858844252 0.9997348394067219 1.3625962700161722 0.23054051889231308 0.3122743543425984 42541230.849026196 54194305.20590669 82592.66563851037 0.10689982564206935 5.839493534944544e-11 10.233624818044628 0.3628614306094503 DSLVQSCPGSLSLCAGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSLVQSCPGSLSLCAGVK 18 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 8744900.0 1618400.0 2419100.0 4707400.0 False True 2216766.2156155054 2312216.1631060666 3595609.0719462247 1.0 1.0430581929741558 1.622006437403175 21.08002519818677 -6.921818213220084 0.8111263605354371 0.988043786075484 1.719386928460756 0.9946713106270952 0.020703145952269273 0.09711364697785775 0.10015653613728252 0.01801183353828418 0.05492868732177097 1.1972415672501955e-07 6.921818213220084 0.7313431423852719 DSLYAQGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSLYAQGKR 9 1 H0Y5B4;H7BZ11;J3KQN4;P83881;H7BY91;H0Y3V9 H0Y5B4 RPL36A;RPL36A-HNRNPH2 60S ribosomal protein L36a 1 5463200.0 1239600.0 1438900.0 2784700.0 True False 1625127.604303475 1224221.728788271 2496565.9567285907 1.0 0.7533080636538501 1.5362276476736185 20.632121571691812 -6.82200606804114 1.3632657402820763 0.8672997251595765 1.5540532446538524 0.8889170711732532 0.10892948417436213 0.19088676310878777 0.696548543969146 0.06278269302849372 0.1446256735851485 1.506586015747069e-07 6.82200606804114 0.6867535194942759 DSLYAQGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSLYAQGKR 9 1 H0Y5B4;H7BZ11;J3KQN4;P83881;H7BY91;H0Y3V9 H0Y5B4 RPL36A;RPL36A-HNRNPH2 60S ribosomal protein L36a 1 9421600.0 1671500.0 2576300.0 5173800.0 True False 1618439.1474328414 3605030.0252270144 3818626.5693270136 1.0 2.2274733226425547 2.359450199523471 20.626171691221394 -10.687578912521968 0.43065874433661644 3.854645143442687e-13 2.36468541795 0.9994899565082619 0.01382419476447331 2.2342097486871104 0.20632216870886158 2.3865911255242427 0.031082004137960466 2.0531519291141193e-11 10.687578912521968 2.3646854179496146 DSLYAQGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSLYAQGKR 9 1 H0Y5B4;H7BZ11;J3KQN4;P83881;H7BY91;H0Y3V9 H0Y5B4 RPL36A;RPL36A-HNRNPH2 60S ribosomal protein L36a 1 7583600.0 1100000.0 2367100.0 4116500.0 True False 1668780.4207719332 1944672.5107632866 3302871.970673958 1.0 1.1653255794214874 1.9792130405905275 20.670362705747905 -6.940153147107528 0.6581452256787673 0.9908878500498576 2.1996790670212385 0.9981837945274574 0.018239768656094103 0.08769697606406984 0.05429367406869349 0.01777563395236685 0.07000258729964907 1.1477488145879056e-07 6.940153147107528 1.208791216971381 DSLYAQGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSLYAQGKR 9 1 H0Y5B4;H7BZ11;J3KQN4;P83881;H7BY91;H0Y3V9 H0Y5B4 RPL36A;RPL36A-HNRNPH2 60S ribosomal protein L36a 1 5217400.0 1239600.0 1397800.0 2580000.0 True False 1697913.6189304122 1336040.574093531 1970657.1367679124 1.0 0.7868719345894402 1.1606345074311335 20.695331633214703 -6.752051819174604 1.6423529598137834 0.8749859606157772 1.1614899135908248 0.6576876053392698 0.08956835087502636 0.296492327076359 1.574104723257704 0.04307122055200121 0.10433683278381767 1.7698977649521816e-07 6.752051819174604 0.2865039529750476 DSLYAQGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSLYAQGKR 9 1 H0Y5B4;H7BZ11;J3KQN4;P83881;H7BY91;H0Y3V9 H0Y5B4 RPL36A;RPL36A-HNRNPH2 60S ribosomal protein L36a 1 8769600.0 1671500.0 3562600.0 3535500.0 True False 1389926.3100053181 3543407.5666792705 4274756.703694972 1.0 2.5493492289283397 3.075527582234641 20.40657696665567 -9.75942198989168 0.2878465317098569 9.359531817764377e-14 3.293381843536831 0.9988629756011381 0.02970652506796736 1.1484884256638637 0.1230347320013372 1.2021143420573668 0.19570400476518524 1.7401152380148707e-10 9.75942198989168 3.2933818435367375 DSLYAQGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSLYAQGKR 9 1 H0Y5B4;H7BZ11;J3KQN4;P83881;H7BY91;H0Y3V9 H0Y5B4 RPL36A;RPL36A-HNRNPH2 60S ribosomal protein L36a 1 5988100.0 1100000.0 2415800.0 2472300.0 True False 1423971.684241659 2281358.606341131 2022366.767940199 1.0 1.6021095303984758 1.4202296227661417 20.441489027840355 -10.12909029538756 4.441143512342686 0.9999311519283136 1.5111695766046975 0.9132826626544568 0.07425216143418885 51834788.39515628 4.9722197689559895 36733.42563311749 0.025418489839703465 7.428646707557659e-11 10.12909029538756 0.5112384246763839 DSLYK(ub)DAMQYASESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSLYKDAMQYASESK 15 1 A0A087WVQ6;Q00610-2;Q00610;J3KS13;K7EJJ5;J3KRF5 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 7235100.0 1542700.0 2200200.0 3492200.0 True False 2022494.6395280517 1871938.736312427 3130860.6435478106 1.0 0.9255593066734867 1.5480192542208149 20.947704448228354 -6.877033531464609 1.0961524107982086 0.9554417114682352 1.589707809459458 0.9712154241453895 0.04708975530432859 0.13029298754389065 0.28840864564879565 0.03317463700561185 0.07965761510436134 1.327291974820301e-07 6.877033531464609 0.6342660979912229 DSLYK(ub)DAMQYASESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSLYKDAMQYASESK 15 1 A0A087WVQ6;Q00610-2;Q00610;J3KS13;K7EJJ5;J3KRF5 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 8700400.0 1930900.0 2376800.0 4392700.0 True False 1869604.636421224 3325868.6348482613 3242120.091824728 1.0 1.7789154830160248 1.7341206951811787 20.834301786292688 -10.374570374084687 4.436623883596952 0.9987293584569701 1.7565180891012453 0.9973773692379262 0.018287395564291303 0.0002301885742023565 3.244955576852291e-05 0.017733390190064913 0.0059022315375703086 4.221138731983476e-11 10.374570374084687 0.7577887306442752 DSLYK(ub)DAMQYASESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSLYKDAMQYASESK 15 1 A0A087WVQ6;Q00610-2;Q00610;J3KS13;K7EJJ5;J3KRF5 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 11105000.0 0.0 11105000.0 0.0 True False 0.0 9123225.986238977 0.0 0.0 DSLYK(ub)DAMQYASESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSLYKDAMQYASESK 15 1 A0A087WVQ6;Q00610-2;Q00610;J3KS13;K7EJJ5;J3KRF5 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 7285200.0 1542700.0 1524000.0 4218500.0 True False 2113077.8798999265 1456664.6408059392 3222177.182734666 1.0 0.6893568167373583 1.5248738408483389 21.010914509751245 -6.806025373300066 1.4310997887229395 0.8298865369971062 1.5382080627494772 0.8492014937038143 0.1339015105561732 0.21227941903098677 0.8575669287493157 0.07358527866378366 0.17055064327013758 1.5630563196855775e-07 6.806025373300066 0.708321525752371 DSLYK(ub)DAMQYASESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSLYKDAMQYASESK 15 1 A0A087WVQ6;Q00610-2;Q00610;J3KS13;K7EJJ5;J3KRF5 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 11029100.0 1930900.0 3427300.0 5670900.0 True False 1605628.9033737786 3408836.4546342124 6856658.970720928 1.0 2.1230537439077604 4.270388354565356 20.614707061726964 -6.960914793732327 0.42234371764652007 0.9074448764155252 5.567312284636433 0.9998026363586795 0.01906092084964935 0.07937594508521309 0.019935774216852168 0.027821585857312533 0.17863549948820134 1.0941710157491035e-07 6.960914793732327 4.659867408220908 DSLYK(ub)DAMQYASESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSLYKDAMQYASESK 15 1 A0A087WVQ6;Q00610-2;Q00610;J3KS13;K7EJJ5;J3KRF5 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 18856800.0 0.0 10608000.0 8248800.0 True False 0.0 10017655.474818554 6747603.039835427 0.0 DSMLK(ub)YPDSHQPR ddPTM_RPMI8226_Bortezomib_1h_R1 2 DSMLKYPDSHQPR 13 1 O00165-5;O00165-3;O00165;O00165-2 O00165-5 HAX1 HCLS1-associated protein X-1 1 25338290.0 4825910.0 5846080.0 14666300.0 True False 6326814.744178921 4973867.651841358 13148771.965083681 1.0 0.786156676456765 2.0782609412076436 22.59304792216014 -6.8643895525612 1.1632851049438897 0.8823137574588298 2.1463075389629647 0.9587601429894621 0.11483541732223622 0.14235213718013237 0.36357420379933014 0.07684180474365195 0.18036321385836349 1.3665025530901522e-07 6.8643895525612 1.2639937815041349 up DSMLK(ub)YPDSHQPR ddPTM_RPMI8226_Bortezomib_2h_R1 2 DSMLKYPDSHQPR 13 1 O00165-5;O00165-3;O00165;O00165-2 O00165-5 HAX1 HCLS1-associated protein X-1 1 70353800.0 6070300.0 11692500.0 52591000.0 True False 5877601.649214228 16361376.225582005 38815839.40381868 1.0 2.783682393271641 6.604026900837682 22.48679615387013 -6.958682937174443 0.4536142288388717 0.8812525275656261 8.658824206438435 0.999718189878096 0.039242682027706165 0.08017499390530444 0.02289531791901076 0.051345678315469774 0.31584412708062715 1.0998084771336314e-07 6.958682937174443 7.7775716788728095 DSMLK(ub)YPDSHQPR ddPTM_RPMI8226_Bortezomib_8h_R1 2 DSMLKYPDSHQPR 13 1 O00165-5;O00165-3;O00165;O00165-2 O00165-5 HAX1 HCLS1-associated protein X-1 1 323958900.0 7955900.0 68291000.0 247712000.0 True False 12069681.954199476 56103937.48998166 198751614.6239735 1.0 4.648336029306976 16.46701341246367 23.524884324633835 -6.94971256146098 0.5619906379280867 0.8470079081801472 20.83510821269992 0.9991785314962861 0.18920781400695302 0.08360137372128797 0.03644165857393732 0.20233577951169424 0.9828828197309701 1.1227613099208847e-07 6.94971256146098 19.988100304519776 DSMLK(ub)YPDSHQPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSMLKYPDSHQPR 13 1 O00165-5;O00165-3;O00165;O00165-2 O00165-5 HAX1 HCLS1-associated protein X-1 1 24226900.0 4153100.0 4277800.0 15796000.0 True False 5688613.30330744 4088792.6512071183 12065310.128831761 1.0 0.7187679023339196 2.120958041183221 22.439645583146085 -6.854535048399099 1.212919473695355 0.8491127225942764 2.182139306031162 0.9466536284804525 0.13989589303499964 0.15254418780858495 0.429571661125408 0.09013179448940986 0.20927919919201426 1.397864100452031e-07 6.854535048399099 1.3330265834368857 up DSMLK(ub)YPDSHQPR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DSMLKYPDSHQPR 13 1 O00165-5;O00165-3;O00165;O00165-2 O00165-5 HAX1 HCLS1-associated protein X-1 1 61361000.0 6070300.0 20145600.0 35145100.0 True False 5047723.409886501 20037071.6542115 42493777.91741771 1.0 3.969526463151046 8.418404588926 22.267201429304407 -6.9652774489641915 0.353258810148103 0.5858734009767106 11.95293303021893 0.999918750436343 0.027479252410187546 0.07786694558446597 0.014528714548922288 0.06058042699370938 0.3815812137002412 1.0832346686198176e-07 6.9652774489641915 11.367059629242219 DSMLK(ub)YPDSHQPR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DSMLKYPDSHQPR 13 1 O00165-5;O00165-3;O00165;O00165-2 O00165-5 HAX1 HCLS1-associated protein X-1 1 175112900.0 7955900.0 63934000.0 103223000.0 True False 10299069.384234741 60376016.69749726 84437473.1574207 1.0 5.862278856953581 8.198553675798419 23.296010646726284 -8.683066704621226 0.3708961618739076 9.45303414804753e-17 8.849085104893298 0.9975817640755961 0.14745300579116494 0.27272348991230944 0.11996796856676926 1.0259423094191007 0.6240347716540193 2.0745948495983218e-09 8.683066704621226 8.849085104893298 DSNNLCLHFNPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSNNLCLHFNPR 12 0 P09382 P09382 LGALS1 Galectin-1 0 3608900.0 0.0 3608900.0 0.0 False True 0.0 3070466.1873820187 0.0 0.0 DSNNLCLHFNPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSNNLCLHFNPR 12 0 P09382 P09382 LGALS1 Galectin-1 0 10566300.0 3029600.0 1898500.0 5638200.0 False True 2933427.006319195 2656580.9505467126 4161386.277625644 1.0 0.9056236766157467 1.418609111002652 21.484155662601047 -6.859215997818308 1.1896550640743624 0.9488958925713329 1.4430847719760804 0.9526805072650723 0.04849484528392441 0.1476164019255225 0.39742565315326484 0.031803032323962574 0.07417523202741874 1.382878428680557e-07 6.859215997818308 0.49418887940474754 DSNNLCLHFNPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSNNLCLHFNPR 12 0 P09382 P09382 LGALS1 Galectin-1 0 162050000.0 0.0 162050000.0 0.0 False True 0.0 133130911.39757118 0.0 0.0 DSNNLCLHFNPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSNNLCLHFNPR 12 0 P09382 P09382 LGALS1 Galectin-1 0 1828000.0 0.0 1828000.0 0.0 False True 0.0 1747232.9156123702 0.0 0.0 DSNNLCLHFNPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSNNLCLHFNPR 12 0 P09382 P09382 LGALS1 Galectin-1 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 DSNSLAYYNMANGAVIHLALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSNSLAYYNMANGAVIHLALK 21 0 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 163550900.0 38033900.0 68569000.0 56948000.0 False True 57700206.95054328 56332326.21795769 45692202.83880491 1.0 0.9762933132326884 0.7918897566168035 25.782073157536143 -6.930621992996363 0.7416669590710517 1.0027404997050289 0.7534257366239896 0.9966591028694605 0.005376670287451615 0.09231618337841221 0.0761069298218044 0.004916649862584036 0.01662864614557915 1.1732160806781354e-07 6.930621992996363 -0.24931476308103928 DSNTDVGAK(ub)NYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSNTDVGAKNYR 12 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 1 6684800.0 2128300.0 1549300.0 3007200.0 True False 2790221.910486516 1318150.4791241 2696043.7910992987 1.0 0.47241779378553483 0.9662470862861241 21.411948435617745 -10.617462550082763 9.570181915308364 1.0000612687801804 0.7193324400358295 0.3010388356827486 0.20160496444434453 0.0002636068198750183 1.0536682085363643e-05 0.19524542270297937 0.06506772248380706 2.4128895910020186e-11 10.617462550082763 -0.2807288287443509 DSNTDVGAK(ub)NYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSNTDVGAKNYR 12 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 1 9585200.0 1424500.0 3439700.0 4721000.0 True False 1379280.0272318793 4813190.147798536 3484428.4730358385 1.0 3.4896395603279196 2.526266170930386 20.395483957927844 -10.342108155466624 6.136324831750061 0.9998156197071216 3.0079528656291523 0.852776033678998 0.39329553929992395 0.000992159036717098 0.00010637236412265103 0.38083912341639614 0.12693558948718864 4.548747653212576e-11 10.342108155466624 2.008137245922031 DSNTDVGAK(ub)NYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSNTDVGAKNYR 12 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 1 25892200.0 3772700.0 5512300.0 16607200.0 True False 5723461.721314798 4528586.997203523 13324779.640805677 1.0 0.7912321629300969 2.328097974549692 22.448456565549126 -6.872613006864671 1.1202357711658102 0.8798513936785398 2.422667549762554 0.9672194831851064 0.12323175412929009 0.13437131744367992 0.31358130390194017 0.08523297692724019 0.20275118176805046 1.3408709847548688e-07 6.872613006864671 1.542816156084014 up DSNTDVGAK(ub)NYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSNTDVGAKNYR 12 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 1 6607500.0 2128300.0 2866300.0 1612900.0 True False 2915190.0251448825 2739657.388413429 1231966.2387182044 1.0 0.9397868971774045 0.4226023786071979 21.475158497140637 -6.928798266610053 0.7565922095123985 1.0082255036531258 0.3196051826145687 0.9962967274482007 0.015771295053094936 0.09326666049396727 0.08077269420001405 0.014267010377592934 0.047109319288380316 1.1781531083299502e-07 6.928798266610053 -0.6886203210385571 down DSNTDVGAK(ub)NYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSNTDVGAKNYR 12 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 1 7530200.0 1424500.0 4782300.0 1323400.0 True False 1184534.8660500022 4756536.800687775 1600116.8212897573 1.0 4.0155312747771745 1.3508397828977137 20.17588923336212 -6.61638509850729 2.13030163031689 3.005936662070226 1.3608358276820447 0.07074348233892691 1.2979800470617098 0.5951324220430667 5.127080420697771 0.5015633394619889 1.4395864752755956 2.4188832183360573e-07 6.61638509850729 -1.6451008343881812 DSNTDVGAK(ub)NYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSNTDVGAKNYR 12 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 1 21476200.0 3772700.0 5940400.0 11763100.0 True False 4883834.521035011 5609811.517968727 9622336.499598507 1.0 1.1486489752686917 1.9702421239201373 22.219582887641575 -6.93759723414368 0.6815555155572666 0.9902826233640875 2.176965780113337 0.9978318806021556 0.019867403336439438 0.08888015508451262 0.059732021802706634 0.01900392901323778 0.07149367460024557 1.1545234696187363e-07 6.93759723414368 1.1866831567492495 DSPCQLEALK(ub)LESCGVTSDNCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSPCQLEALKLESCGVTSDNCR 22 1 P13489 P13489 RNH1 Ribonuclease inhibitor 1 71004200.0 9219200.0 13996000.0 47789000.0 True False 13986200.41380054 11498304.44875287 38343483.203337185 1.0 0.8221178095951779 2.7415225056765737 23.73750074760839 -6.884228908937519 1.0559606252216331 0.8821532384976349 2.889064490924213 0.976938430908038 0.1315018469107336 0.12394883279441167 0.2502233528509673 0.095537703358796 0.2337223721331472 1.305482609972102e-07 6.884228908937519 2.006911252426578 up DSPCQLEALK(ub)LESCGVTSDNCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSPCQLEALKLESCGVTSDNCR 22 1 P13489 P13489 RNH1 Ribonuclease inhibitor 1 61778500.0 9219200.0 9801300.0 42758000.0 True False 11934436.137600627 9255849.038964855 34976482.73412905 1.0 0.7755581354868859 2.9307193344419655 23.50862706970084 -6.881186322626442 1.0731254402993622 0.8585756917646333 3.0869938090481495 0.9746313083717077 0.1540831962165598 0.12658601648834258 0.2659609065195297 0.11048225160368257 0.2680060510269061 1.314660690589308e-07 6.881186322626442 2.2284181172835162 up DSPDLLLLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSPDLLLLLR 10 0 A0A5H1ZRP4;Q8WX92;Q8WX92-2 A0A5H1ZRP4 NELFB Negative elongation factor B 0 3257260.0 968760.0 1458700.0 829800.0 False True 1270053.7414851855 1241067.6459680647 743940.2560036577 1.0 0.9771772685120987 0.5857549422544144 20.276458114300965 -6.918873249936111 0.8330408792892994 1.0089922497772268 0.5242419627646674 0.9938621439929005 0.014895324650578402 0.09883938531698688 0.10908315661007184 0.01275784425975489 0.03781370960271247 1.2053876848206148e-07 6.918873249936111 -0.4847502870125594 DSQK(ub)QLLCGAAVGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSQKQLLCGAAVGTR 15 1 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 1 12721900.0 2765700.0 5782400.0 4173800.0 True False 3625859.4830768984 4919688.459618658 3741935.213916686 1.0 1.3568337335135277 1.0320133009515542 21.78989158514087 -10.51242390758706 9.673978864655854 0.9999962679454747 1.1944235172325408 0.32326983496669126 0.13260738630115818 1.0674144343379719e-05 5.379648574427907e-07 0.1283990131183161 0.042798849894039974 3.073095752920463e-11 10.51242390758706 0.19442724928706612 DSQK(ub)QLLCGAAVGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSQKQLLCGAAVGTR 15 1 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 1 67771800.0 12126700.0 14699100.0 40946000.0 True False 18397090.480522733 12075930.7604075 32853005.15273068 1.0 0.6564043794420896 1.78577178752872 24.132974284774956 -6.825072154676619 1.3496978057452576 0.8156860211310399 1.81323121305632 0.8956624219473684 0.15268679677869965 0.18697883243098973 0.6678474889317307 0.08886183221938923 0.20459790159349814 1.4959870887363112e-07 6.825072154676619 0.99754519192528 DSQK(ub)QLLCGAAVGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSQKQLLCGAAVGTR 15 1 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 1 12502900.0 4689500.0 1740300.0 6073100.0 True False 3899527.03007475 1730924.658477497 7342957.131158246 1.0 0.44388066684187516 1.883037884986141 21.89486772080038 -6.801939564421939 1.4480373956031958 0.6939164656590195 1.9038567010870275 0.8377608471107323 0.23867873929090233 0.2179991539707193 0.9022307484732507 0.1296601036662212 0.301184742874262 1.5778308223007578e-07 6.801939564421939 1.209940235428008 DSQK(ub)QLLCGAAVGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSQKQLLCGAAVGTR 15 1 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 1 53119600.0 12126700.0 10335700.0 30657200.0 True False 15698252.202993937 9760509.209189512 25077904.169435892 1.0 0.6217577016203122 1.5974965776542365 23.904100606867406 -6.801595189261598 1.4494261840203397 0.7917279294171995 1.6114970986863641 0.8367782967228353 0.1622823569460057 0.21848762796743332 0.9060248940906541 0.08807495613990775 0.20463084661823544 1.5790824643404412e-07 6.801595189261598 0.8197691692691647 DSRPSQAAGDNQGDEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSRPSQAAGDNQGDEAK 17 1 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 17135000.0 5832700.0 1671700.0 9630600.0 False True 5647544.131158559 2339218.5278003323 7108056.948192963 1.0 0.41420101790695635 1.2586102530791183 22.429192208524622 -6.72012119637085 1.7589738704105096 0.643652439750083 1.2572945842384176 0.5130553770671809 0.2465024846550615 0.3550778895116322 2.1471240735100685 0.11127261414211381 0.27928607711850245 1.9049290448393394e-07 6.72012119637085 0.6136421444883345 DSSDPNELYVNHK(ub)VYTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSSDPNELYVNHKVYTR 17 1 A0A2R8YEZ4;A0A2R8Y5D3;O15160-2;O15160;A0A2R8YEY5;E7EQB9;D6RDJ3 A0A2R8YEZ4 POLR1C DNA-directed RNA polymerases I and III subunit RPAC1 1 48276400.0 1862100.0 4173300.0 42241000.0 True False 2824941.8377449275 3428542.0088582733 33892047.835112035 1.0 1.213668176473036 11.997432082413107 21.429789733750845 -6.9111866537602475 0.8876194063597332 0.6785143666330734 13.426992551326595 0.9913616324590337 0.4772258821340971 0.10363840667684117 0.1345511147037608 0.3930182817874348 1.0940324700035344 1.2269118081050604e-07 6.9111866537602475 12.748478184693521 up DSSDPNELYVNHK(ub)VYTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSSDPNELYVNHKVYTR 17 1 A0A2R8YEZ4;A0A2R8Y5D3;O15160-2;O15160;A0A2R8YEY5;E7EQB9;D6RDJ3 A0A2R8YEZ4 POLR1C DNA-directed RNA polymerases I and III subunit RPAC1 1 43851600.0 1862100.0 5328500.0 36661000.0 True False 2410525.1574785416 5031964.290872048 29989074.17362605 1.0 2.0874971062884837 12.440888277223056 21.200916055843294 -6.927011416235481 0.7709361836446748 0.8238796255129105 14.413135883817278 0.9959174050443136 0.329450648574534 0.09421975459073792 0.08550438710814141 0.29497123539110115 0.9526628656569984 1.1830104576936798e-07 6.927011416235481 13.589256258304367 DSSFQSK(ub)QTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSSFQSKQTGR 11 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 10775900.0 2471900.0 3511400.0 4792600.0 True False 3240684.837913649 2987512.807329997 4296707.72586542 1.0 0.9218769972254864 1.3258641123002994 21.627867292266977 -6.8565655017264575 1.2029137573948958 0.9579409657213037 1.3441869487746545 0.9493322980351233 0.039382398348675705 0.15038342217109202 0.4154534649999878 0.025567584456734217 0.059472281317160175 1.3913439319372335e-07 6.8565655017264575 0.3862459830533508 DSSFQSK(ub)QTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSSFQSKQTGR 11 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 15227000.0 2356200.0 4273300.0 8597500.0 True False 2281403.720718671 5979650.9749651 6345556.830528618 1.0 2.621040248449071 2.781426528282196 21.12149034010418 -10.466664153974984 0.4688056331215524 1.0011335396926502e-20 2.7808730850277437 0.9994943495711789 0.01809362218041262 1.8787202520531585 0.22149384170725192 2.3194210166353644 0.03461934997001019 3.414568629399776e-11 10.466664153974984 2.7808730850277437 DSSFQSK(ub)QTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSSFQSKQTGR 11 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 12077800.0 2471900.0 3455800.0 6150100.0 True False 3385828.2305857423 3303111.329197615 4697573.045285402 1.0 0.975569669884341 1.3874221387990289 21.69107735378987 -6.892809381628974 1.0055882322448122 0.9793379828597328 1.4248619356350953 0.9826372796386829 0.024858584785897943 0.11689439040689724 0.20875686134895788 0.018762366298914184 0.0472749190173712 1.2799429670798115e-07 6.892809381628974 0.4455239527753625 DSSFQSK(ub)QTGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSSFQSKQTGR 11 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 13593700.0 2356200.0 4496200.0 6741300.0 True False 1959284.697358378 4471978.078174173 8150874.66175051 1.0 2.282454450955267 4.1601277612896155 20.901895615538457 -6.965656391673731 0.34660207219263117 0.8113023523397079 5.694310338943637 0.9999260439475798 0.011160114443014455 0.07773892052335125 0.01407848024770293 0.026005374646822815 0.16176160866277317 1.082289906790793e-07 6.965656391673731 4.883007986603929 DSSGNLHGYVAEGGAK(ub)DIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSSGNLHGYVAEGGAKDIR 19 1 Q8IZ83-3;Q8IZ83;F5H4B6;M0QY06 Q8IZ83-3 ALDH16A1 Aldehyde dehydrogenase family 16 member A1 1 5181900.0 0.0 1565400.0 3616500.0 True False 0.0 2190472.383453155 2669230.1573255872 0.0 DSSGNLHGYVAEGGAK(ub)DIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSSGNLHGYVAEGGAKDIR 19 1 Q8IZ83-3;Q8IZ83;F5H4B6;M0QY06 Q8IZ83-3 ALDH16A1 Aldehyde dehydrogenase family 16 member A1 1 6128200.0 0.0 2314100.0 3814100.0 True False 0.0 2301633.483987116 4611610.675594121 0.0 DSSGNLHGYVAEGGAK(ub)DIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSSGNLHGYVAEGGAKDIR 19 1 Q8IZ83-3;Q8IZ83;F5H4B6;M0QY06 Q8IZ83-3 ALDH16A1 Aldehyde dehydrogenase family 16 member A1 1 39611700.0 4606700.0 4521000.0 30484000.0 True False 5963463.961632776 4269402.375721605 24936224.79225379 1.0 0.7159265828031695 4.181500039689404 22.50771915312767 -6.887021903747209 1.0397978488166641 0.8002815770258005 4.462787974514746 0.9789242120373366 0.22807238057677454 0.12159445372075442 0.236207904040765 0.16774089416155943 0.4139549902866358 1.297113849083558e-07 6.887021903747209 3.6625063974889454 up DSSSVVEWTQAPK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSSSVVEWTQAPKER 15 1 Q8TC07-2;Q8TC07-3;Q8TC07;F8WCB5 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 37022500.0 14430200.0 5250600.0 17341700.0 True False 18918131.94225557 4467230.946678498 15547347.237332636 1.0 0.2361348869071202 0.8218225396031865 24.173266302006212 -10.257627849883406 7.577933595552606 1.000001115305075 0.5289787132576648 0.46304635127005855 0.2391059829589618 4.505328395282064e-06 4.4113471204714175e-07 0.23151392092797168 0.07717112416488449 5.5255072122503766e-11 10.257627849883406 -0.4710224020474102 DSSSVVEWTQAPK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSSSVVEWTQAPKER 15 1 Q8TC07-2;Q8TC07-3;Q8TC07;F8WCB5 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 18495300.0 3886300.0 10698600.0 3910400.0 True False 3762931.533753072 14970606.772461945 2886148.930514581 1.0 3.9784425090324627 0.7669948030215672 21.84342560924458 -6.663025795702568 1.9618962956977706 2.9122993401970714 0.780178087364093 0.24877590178870457 1.2672216269927774 0.4772226264459773 3.534094892494805 0.5212463166379694 1.4055305635587687 2.1725721311984842e-07 6.663025795702568 -2.1321212528329783 DSSSVVEWTQAPK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSSSVVEWTQAPKER 15 1 Q8TC07-2;Q8TC07-3;Q8TC07;F8WCB5 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 40757300.0 19856400.0 9263800.0 11637100.0 True False 30123610.49728708 7610602.511600234 9337022.084277874 1.0 0.25264576144634593 0.3099569384326876 24.84439136032904 -10.585647652056256 9.83769710506542 1.0000602939776015 0.28130134993951694 0.9952534291331464 0.023397190029145885 3.0943452934158744e-05 1.3032871662257998e-06 0.02265608992407474 0.007551410610911017 2.5962849026986238e-11 10.585647652056256 -0.7187589440380846 DSSSVVEWTQAPK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSSSVVEWTQAPKER 15 1 Q8TC07-2;Q8TC07-3;Q8TC07;F8WCB5 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 26206600.0 14430200.0 2672200.0 9104200.0 True False 19765434.901492123 2554133.368216293 6953975.46688465 1.0 0.12922221954364776 0.35182506742412656 24.236476363529103 -10.323762006122255 6.311481967966492 1.0000409685274196 0.24052364370600213 0.9394691589080332 0.09087723209959349 5.239163110383721e-05 5.613651733473509e-06 0.08799621659779344 0.029330500539262526 4.745019416376654e-11 10.323762006122255 -0.7595173248214175 DSSSVVEWTQAPK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSSSVVEWTQAPKER 15 1 Q8TC07-2;Q8TC07-3;Q8TC07;F8WCB5 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 16178000.0 3886300.0 5370100.0 6921600.0 True False 3231630.642281588 5341170.205418606 8368874.558137507 1.0 1.652778673260644 2.589675456298104 21.623830884678856 -6.965980224379441 0.3408102268717475 0.8993291585859382 3.374298910768633 0.999931948790573 0.0053820835353327505 0.0776298896623617 0.013695730668132924 0.013193089814185424 0.08104452234078796 1.0814831955671738e-07 6.965980224379441 2.4749697521826945 DSSVK(ub)LYQTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSSVKLYQTR 10 1 Q5JP01 Q5JP01 RBBP7 1 4066340.0 752670.0 841470.0 2472200.0 True False 986757.6588666473 715925.9560243696 2216400.459016922 1.0 0.7255337210624291 2.2461446730118073 19.912336286291243 -6.860185145342283 1.1846763115089232 0.850994742394537 2.3200839236511386 0.9538733052684353 0.14211132950400118 0.1466176803204435 0.3908809287376008 0.09354870685914944 0.2184342413795415 1.3797959143963347e-07 6.860185145342283 1.4690891812566016 up DSSVK(ub)LYQTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSSVKLYQTR 10 1 Q5JP01 Q5JP01 RBBP7 1 5472370.0 752670.0 0.0 4719700.0 True False 1030952.4391419432 0.0 3605004.065272676 1.0 0.0 3.4967704895029916 19.975546347814134 -6.830266063650539 1.326779750770794 0.4657828972627195 3.5913382214340963 0.9063986961757876 0.44988886776570536 0.18048072822194908 0.6212707328066509 0.26623256951531404 0.6126528198534781 1.478202513304029e-07 6.830266063650539 3.1255553241713767 DSTHCPLEK(ub)ALEICQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSTHCPLEKALEICQQR 17 1 P49754-2;P49754-3;P49754 P49754-2 VPS41 Vacuolar protein sorting-associated protein 41 homolog 1 4422700.0 1917500.0 0.0 2505200.0 True False 2513861.0690964162 0.0 2245985.9355752724 1.0 0.0 0.8934407566057623 21.261473489383256 -9.131904837219233 12.043139526280765 0.9998970661187756 0.4467203776330603 0.3383286943967986 0.36474566635649647 0.0 0.0 0.353163470662408 0.11772115688746931 7.380659377155336e-10 9.131904837219233 -0.5531766884857153 DSTLIMQLLR ddPTM_RPMI8226_Bortezomib_1h_R1 2 DSTLIMQLLR 10 0 P61981;P27348;P31946;P31946-2;P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6;P31947-2;P31947;Q04917;P62258;P62258-2;K7EM20 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917;P62258 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH;YWHAE 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta;14-3-3 protein epsilon 0 1120562280.0 309773710.0 465186980.0 345601590.0 False True 406116333.66287476 395782895.86864585 309842052.7113416 1.0 0.9745554735486042 0.7629391556768748 28.597317811528708 -6.929380278605473 0.7518600973075387 1.0032931329624342 0.7201729608508061 0.9964150554127884 0.006362441097086002 0.0929609222446694 0.07926559512500503 0.005775263345886555 0.019213299303555868 1.1765752849602682e-07 6.929380278605473 -0.2831201721116281 DSTLIMQLLR ddPTM_RPMI8226_Bortezomib_2h_R1 2 DSTLIMQLLR 10 0 P61981;P27348;P31946;P31946-2;P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6;P31947-2;P31947;Q04917;P62258;P62258-2;K7EM20 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917;P62258 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH;YWHAE 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta;14-3-3 protein epsilon 0 1250575150.0 398575900.0 360105150.0 491894100.0 False True 385923326.2239174 503897014.3185488 363052278.7033127 1.0 1.3056920379728008 0.9407368097067689 28.523739005907636 -6.684573670440256 1.886387109863316 1.1926229407090767 0.9420972652061692 0.3448841701099832 0.12943306374117977 0.4284168583372349 2.9514675957797882 0.054988104385258474 0.14414348930423734 2.0674086525622924e-07 6.684573670440256 -0.2505256755029075 DSTLIMQLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSTLIMQLLR 10 0 P61981;P27348;P31946;P31946-2;P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6;P31947-2;P31947;Q04917;P62258;P62258-2;K7EM20 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917;P62258 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH;YWHAE 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta;14-3-3 protein epsilon 0 194153700.0 76204800.0 76209900.0 41739000.0 False True 115608252.91712816 62609647.91433353 33489268.355146375 1.0 0.5415672872352306 0.2896788724863146 26.78466915016951 -9.19265007006377 0.18583296109157776 1.4608262998314185 3.311082593820974e-17 0.9996392588686207 0.005584856676932949 0.6292466516932327 0.06566857755993435 0.3175148128335152 0.1502930675877904 6.417264352043829e-10 9.19265007006377 -1.4608262998314185 DSTLIMQLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DSTLIMQLLR 10 0 P61981;P27348;P31946;P31946-2;P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6;P31947-2;P31947;Q04917;P62258;P62258-2;K7EM20 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917;P62258 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH;YWHAE 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta;14-3-3 protein epsilon 0 1387117200.0 309773710.0 349943590.0 727399900.0 False True 424305421.90674424 334481925.0850988 555603024.8911873 1.0 0.788304621661452 1.3094412567117755 28.6605278730516 -6.796441621809892 1.4705637167045509 0.8826661114476648 1.316005309500833 0.8215042841010312 0.0904110396274252 0.225879152744381 0.9647263613816613 0.04837695508460426 0.11275131141644648 1.5979323098828373e-07 6.796441621809892 0.43333919805316823 DSTLIMQLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DSTLIMQLLR 10 0 P61981;P27348;P31946;P31946-2;P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6;P31947-2;P31947;Q04917;P62258;P62258-2;K7EM20 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917;P62258 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH;YWHAE 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta;14-3-3 protein epsilon 0 790386510.0 398575900.0 181159310.0 210651300.0 False True 331433520.7562364 180183368.83972257 254697512.8884351 1.0 0.5436485978503192 0.7684723992530639 28.304144281341912 -10.12572624310835 5.16479935379104 1.0000104962317393 0.656060498551269 0.7573085045458969 0.09178393257973148 1.109356162380586e-05 1.8777358348907983e-06 0.08887212129570031 0.02962313686068177 7.486412567316432e-11 10.12572624310835 -0.3439499976804703 DSTLIMQLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSTLIMQLLR 10 0 P61981;P27348;P31946;P31946-2;P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6;P31947-2;P31947;Q04917;P62258;P62258-2;K7EM20 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917;P62258 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH;YWHAE 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta;14-3-3 protein epsilon 0 231152100.0 76204800.0 102334600.0 52612700.0 False True 98648615.82118067 96639589.55065687 43037728.45188991 1.0 0.9796345214395553 0.43627300893814824 26.55579547226196 -6.914823546036484 0.8622358826690091 1.0143674231815756 0.35829426135934916 0.9926181404593051 0.022431034114283613 0.10131431805948289 0.12210317702206032 0.018814329907397644 0.05384773616566869 1.2166802377394587e-07 6.914823546036484 -0.6560731618222264 down DSTQVGDLK(ub)LDGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSTQVGDLKLDGGR 14 1 Q8TDN4-2;Q8TDN4;Q8TDN4-4 Q8TDN4-2 CABLES1 CDK5 and ABL1 enzyme substrate 1 1 9504500.0 2105100.0 3238800.0 4160600.0 True False 2759806.485817397 2755583.664743516 3730101.0232933396 1.0 0.9984698850823122 1.351580642506013 21.396135679900336 -6.905922951275584 0.9230393877892836 0.987607736362337 1.3934499577357229 0.9892901209485871 0.0171892943710967 0.10717688532042509 0.15384382582888897 0.013795328882250737 0.037087494793989935 1.2418726102147606e-07 6.905922951275584 0.4058422213733859 DSTQVGDLK(ub)LDGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSTQVGDLKLDGGR 14 1 Q8TDN4-2;Q8TDN4;Q8TDN4-4 Q8TDN4-2 CABLES1 CDK5 and ABL1 enzyme substrate 1 1 17282600.0 3143900.0 2696700.0 11442000.0 True False 3044098.615383853 3773506.3731047213 8444996.947357781 1.0 1.2396137083190033 2.7742192400336836 21.537583665885975 -6.934471046046147 0.7091391670867405 0.9800810099891659 3.1284083181748303 0.9973462176808323 0.040491123621226616 0.09038189807964388 0.06678991233876692 0.0379249121860418 0.1356043965933619 1.1628640753372972e-07 6.934471046046147 2.1483273081856646 up DSTQVGDLK(ub)LDGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSTQVGDLKLDGGR 14 1 Q8TDN4-2;Q8TDN4;Q8TDN4-4 Q8TDN4-2 CABLES1 CDK5 and ABL1 enzyme substrate 1 1 20770200.0 3123400.0 3714800.0 13932000.0 True False 4738426.151126412 3051864.916135125 11178334.093387472 1.0 0.6440672110948991 2.3590816310876077 22.175976522750265 -6.852573256813728 1.2226748527683227 0.8095667724246237 2.431094433572838 0.9439576947460737 0.17494494381701825 0.1546502308710757 0.4436086407514697 0.11188671701267155 0.2593640336991367 1.4041928042915278e-07 6.852573256813728 1.6215276611482143 up DSTQVGDLK(ub)LDGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSTQVGDLKLDGGR 14 1 Q8TDN4-2;Q8TDN4;Q8TDN4-4 Q8TDN4-2 CABLES1 CDK5 and ABL1 enzyme substrate 1 1 10777000.0 2105100.0 1699900.0 6972000.0 True False 2883412.358188457 1624792.7971824224 5325357.19284724 1.0 0.5634965087696373 1.8468940724777112 21.459345741423228 -6.814929412524324 1.393679030171445 0.7634528025273486 1.871975851860918 0.8723121442000958 0.190387442660196 0.20015817548561074 0.7652437019148394 0.10738553834644343 0.24790143644048218 1.531336335169722e-07 6.814929412524324 1.1085230493335694 DSTQVGDLK(ub)LDGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSTQVGDLKLDGGR 14 1 Q8TDN4-2;Q8TDN4;Q8TDN4-4 Q8TDN4-2 CABLES1 CDK5 and ABL1 enzyme substrate 1 1 12352700.0 3143900.0 3624900.0 5583900.0 True False 2614292.148385115 3605371.9442136874 6751467.672963472 1.0 1.3791006282296248 2.5825222621480726 21.31798894132025 -6.950174001756999 0.5569331192536263 0.9840008731864407 3.0348332035992445 0.9992148465934058 0.018903960309327672 0.08341601105725292 0.035674232110237326 0.020339855673703208 0.09997156325890565 1.1215690033295784e-07 6.950174001756999 2.0508323304128036 up DSTQVGDLK(ub)LDGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSTQVGDLKLDGGR 14 1 Q8TDN4-2;Q8TDN4;Q8TDN4-4 Q8TDN4-2 CABLES1 CDK5 and ABL1 enzyme substrate 1 1 32903700.0 3123400.0 4508300.0 25272000.0 True False 4043302.8714185404 4257409.141885793 20672755.312617734 1.0 1.0529533100230348 5.112838679177394 21.947102844842714 -6.909744104775587 0.8974747912462836 0.8732783567029164 5.634650599252976 0.9908246660567325 0.18453080178499887 0.10458749593418946 0.13968658461972078 0.15088695249218817 0.4157819756862057 1.2309938840332754e-07 6.909744104775587 4.76137224255006 up DSVFLSCSEDNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSVFLSCSEDNR 12 0 Q9BQA1;H0Y711;Q9BQA1-2 Q9BQA1 WDR77 Methylosome protein 50 0 11344800.0 2234600.0 3730500.0 5379700.0 False True 2929582.2398971813 3173923.941375107 4823060.249726284 1.0 1.0834049640765508 1.6463303825515947 21.48226351950095 -6.933398433769124 0.7183464425441286 0.9924248760140789 1.772578490628881 0.9971650917874286 0.015283699904526804 0.09091104558069248 0.06931361104350554 0.0142172223175192 0.050017289005656926 1.1657396445336733e-07 6.933398433769124 0.7801536146148021 DSVFLSCSEDNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSVFLSCSEDNR 12 0 Q9BQA1;H0Y711;Q9BQA1-2 Q9BQA1 WDR77 Methylosome protein 50 0 9047100.0 2234600.0 2394100.0 4418400.0 False True 3060792.007794369 2288320.7457700116 3374864.9198043984 1.0 0.7476237326622509 1.102611647968969 21.545473581023842 -6.715761378469507 1.774393877903145 0.8457672575056236 1.1019372899001287 0.4925057048045757 0.10625981155723985 0.36362699115603897 2.2350226621654192 0.04759139495817295 0.12007976956745547 1.9241486550325815e-07 6.715761378469507 0.2561700323945051 DSVK(ub)TVLQDER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSVKTVLQDER 11 1 Q5SRE5 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 5033600.0 1786200.0 1509100.0 1738300.0 True False 2341725.4975854065 1283948.1624257283 1558437.3909510195 1.0 0.5482914900784184 0.6655081445532156 21.15914053906479 -10.138002153703802 7.694118696557365 1.0000000916620366 0.6068998173158268 0.9374831762632196 0.04785349880322928 7.521994223971616e-08 8.435068762397993e-09 0.0463339620274188 0.015444650326888635 7.277761954229375e-11 10.138002153703802 -0.39310027434620987 DSVK(ub)TVLQDER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSVKTVLQDER 11 1 Q5SRE5 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 5469000.0 1185200.0 1186300.0 3097500.0 True False 1147576.4747456787 1659995.7764727757 2286171.826991844 1.0 1.4465230100160926 1.9921738352979885 20.13015886767791 -6.96843955079977 0.293073527204248 0.8972278967765954 2.5583999076762556 0.9999675222443112 0.002312198498222889 0.07681238518094238 0.010833175225544316 0.009378409842117153 0.04930873386841929 1.0753762709835274e-07 6.96843955079977 1.6611720108996602 DSVK(ub)TVLQDER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSVKTVLQDER 11 1 Q5SRE5 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 26095000.0 4145800.0 7301200.0 14648000.0 True False 6289481.698578444 5998243.815464022 11752816.37955354 1.0 0.9536944541582419 1.8686462482607946 22.584509702215716 -6.894980080626397 0.9924299011050007 0.9565454025751712 1.955477209555214 0.9838999191768473 0.053396574954605286 0.11519639296282687 0.19897641884541556 0.04070264658377979 0.103473964575691 1.2735614929156674e-07 6.894980080626397 0.9989318069800428 DSVK(ub)TVLQDER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSVKTVLQDER 11 1 Q5SRE5 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 5867700.0 1185200.0 1863300.0 2819200.0 True False 985546.3132625197 1853262.0330639074 3408681.6854919745 1.0 1.880441343166239 3.458672250731666 19.910564143112186 -6.962128638409458 0.40431715298124327 0.9172676587049333 4.479877269055759 0.9998411807791789 0.012818280497936714 0.0789493160690212 0.01838487974917359 0.020303787336360193 0.13202336045188298 1.0911170987302755e-07 6.962128638409458 3.562609610350826 DSVK(ub)TVLQDER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSVKTVLQDER 11 1 Q5SRE5 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 21108500.0 4145800.0 5583700.0 11379000.0 True False 5366819.825935524 5272962.186533227 9308138.758399693 1.0 0.982511497973395 1.7343862958501934 22.355636024308165 -6.9015784497375705 0.9512639858355174 0.9700784844918904 1.815879313926443 0.9873343277917281 0.039433302668069624 0.11025239740124124 0.17095266395068465 0.030996459337877064 0.08130266556976047 1.254358133655646e-07 6.9015784497375705 0.8458008294345527 DSVK(ub)VINK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSVKVINK 8 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-9;Q9UKT9-10;Q9UKT9-11;Q9UKT9-16;Q9UKT9-12 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 7095480.0 697680.0 2050000.0 4347800.0 True False 675532.5302907241 2868575.6906087706 3208980.7487958483 1.0 4.246391642123055 4.750297883382199 19.36566571868666 -9.806293904242077 0.47796989771741183 3.530200059223184e-21 4.752336841861264 0.9988857791986002 0.05547470110992942 1.0988333015394252 0.21252111536784485 1.831164677665571 0.10629449048146287 1.5620901567069317e-10 9.806293904242077 4.752336841861264 DSVK(ub)VINK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSVKVINK 8 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-9;Q9UKT9-10;Q9UKT9-11;Q9UKT9-16;Q9UKT9-12 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 5351080.0 697680.0 1277300.0 3376100.0 True False 580151.8324645592 1270418.9313758018 4082026.9006773094 1.0 2.1898042206966744 7.036135494627909 19.146070994120937 -6.944457980169489 0.6166960940821138 0.9468164374538482 8.534422271385933 0.9986914364544978 0.09443634334658042 0.08579042820931543 0.045781310657994886 0.0953934082509902 0.4096417658828782 1.136428246594237e-07 6.944457980169489 7.587605833932085 DSVLTSK(ub)NQIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSVLTSKNQIER 12 1 O75937 O75937 DNAJC8 DnaJ homolog subfamily C member 8 1 3693500.0 1287400.0 1300500.0 1105600.0 True False 1687793.8671993364 1106470.4693092962 991203.117664067 1.0 0.655572040408781 0.5872773547333913 20.68670728561531 -13.999999999999998 0.22747829355706292 3.1492040792864358 0.5532650232280758 0.9995064549478455 0.004012780772174755 13.214003138448213 0.15103480544401815 12.809108056758399 0.036015662658251485 1.0000000000000041e-14 13.999999999999998 -2.59593905605836 DSVLTSK(ub)NQIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSVLTSKNQIER 12 1 O75937 O75937 DNAJC8 DnaJ homolog subfamily C member 8 1 4841600.0 1361200.0 1543000.0 1937400.0 True False 1317989.451083209 2159127.946638702 1429936.8192458465 1.0 1.638198200193629 1.0849379849517247 20.329907392681637 -10.28441793321669 4.13056780628012 0.9996049798167892 1.3615680925887659 0.3628364836787117 0.22586753712917512 22237404.602972217 55367879.72168685 48148.57436378488 0.07732047389101439 5.194958311528319e-11 10.28441793321669 0.3619631127719767 DSVLTSK(ub)NQIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSVLTSKNQIER 12 1 O75937 O75937 DNAJC8 DnaJ homolog subfamily C member 8 1 12243100.0 2532900.0 2132100.0 7578100.0 True False 3842594.479793849 1751610.0968266658 6080285.21340077 1.0 0.4558404760214608 1.5823385073220035 21.873649301941413 -6.775343851539489 1.5538769938802466 0.690019093488771 1.5900133882340415 0.7506094072570744 0.22970897909813873 0.257880481188861 1.229474110045057 0.11647150162535172 0.27592804187270425 1.677475355409417e-07 6.775343851539489 0.8999942947452705 DSVLTSK(ub)NQIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSVLTSKNQIER 12 1 O75937 O75937 DNAJC8 DnaJ homolog subfamily C member 8 1 3788800.0 1287400.0 1076900.0 1424500.0 True False 1763386.5706768446 1029318.9971679228 1088062.438498408 1.0 0.5837171578168688 0.6170300129260793 20.7499173471382 -9.87909269134073 5.5410958533799315 1.000000245809945 0.6003735860200343 0.9948153533894435 0.013599916155120129 4.130326556753083e-08 8.357162859584594e-09 0.013168070432983816 0.00438935406396656 1.3210136605483764e-10 9.87909269134073 -0.39962665978991074 DSVLTSK(ub)NQIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSVLTSKNQIER 12 1 O75937 O75937 DNAJC8 DnaJ homolog subfamily C member 8 1 5422300.0 1361200.0 2544100.0 1517000.0 True False 1131898.1113845282 2530394.4283356867 1834197.6861844938 1.0 2.2355319819736508 1.620461831092658 20.110312668115913 -10.084975946110246 5.58664351499413 0.9999928281148321 1.927996906533396 0.7521787388080178 0.2511013376133676 2.2430686343515967e-05 3.673432905340234e-06 0.243129702865112 0.08104260823212446 8.222881920448968e-11 10.084975946110246 0.9280040784185638 DSVLTSK(ub)NQIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSVLTSKNQIER 12 1 O75937 O75937 DNAJC8 DnaJ homolog subfamily C member 8 1 10625300.0 2532900.0 2401800.0 5690600.0 True False 3278888.980923365 2268137.7186481194 4654969.190486799 1.0 0.6917397117877992 1.419678805098158 21.644775624033862 -6.791659588871151 1.4897698796025578 0.8280853759063938 1.427770767167211 0.8066386092748046 0.13118779892110022 0.23288417018434182 1.0210541270930977 0.06930748487917071 0.16206662928765272 1.6156244284224815e-07 6.791659588871151 0.5996853912608173 DSVSK(ub)DIDSSDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSVSKDIDSSDR 12 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 2360130.0 786610.0 831300.0 742220.0 True False 761639.4961185447 1163242.4251722319 547810.3158772844 1.0 1.5272874254819107 0.7192514551425271 19.53874876844101 -6.730617610951659 1.7210591370567676 1.317097284757557 0.7196822730433114 0.5621308233637181 0.22164758507072038 0.3350612249847947 1.9446305546303981 0.1020478868107694 0.2530402109584467 1.8594409412744236e-07 6.730617610951659 -0.5974150117142456 DSVSK(ub)DIDSSDRK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSVSKDIDSSDRK 13 2 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 4654800.0 1540100.0 1944800.0 1169900.0 True False 1491210.3685081196 2721368.7819980197 863468.0937523046 1.0 1.8249395521039806 0.5790384187149669 20.508052365640943 -6.728146664672022 1.729774959233128 1.4974578818188 0.5799957667139295 0.5507594742246968 0.34683830086646106 0.3397164836350247 1.990458687543527 0.15894584129384476 0.39527563892034806 1.8700505029125336e-07 6.728146664672022 -0.9174621151048705 DSVSK(ub)DIDSSDRK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSVSKDIDSSDRK 13 2 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 3470800.0 1353600.0 1191800.0 925400.0 True False 2053510.1614153548 979113.9784240992 742494.2843827718 1.0 0.476800162385979 0.3615732214692414 20.96966065556847 -13.999999999999998 0.21262394414552813 4.058962628626433 0.2954061995142256 0.9994916467172243 0.006263686872505959 12.80939037996727 0.14613394460513932 16.390188965776378 0.06702127008389824 1.0000000000000041e-14 13.999999999999998 -3.7635564291122074 DSVSK(ub)DIDSSDRK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSVSKDIDSSDRK 13 2 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 4512090.0 1540100.0 2134200.0 837790.0 True False 1280661.3879983206 2122702.64099447 1012968.0154967098 1.0 1.6575049899117078 0.7909725591711508 20.28845764107522 -6.703786296240069 1.8171131358880794 1.4067487649136596 0.793335052209649 0.4357105132769916 0.2773520814369615 0.3876818093061461 2.4911482493005646 0.12164192642433752 0.3114065682010451 1.9779426891063977e-07 6.703786296240069 -0.6134137127040107 DSVSK(ub)DIDSSDRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSVSKDIDSSDRK 13 2 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 3617440.0 1353600.0 1518500.0 745340.0 True False 1752261.8834450098 1433994.1401312223 609695.7678342228 1.0 0.8183674790162863 0.3479478573348517 20.74078697766092 -6.9546996882774925 0.5046193494547305 1.009055401027389 0.13681023701446865 0.9995203484250361 0.006017588253221384 0.08165168843475179 0.028563642790981527 0.006997249414396445 0.03881278156172409 1.1099420674549902e-07 6.9546996882774925 -0.8722451640129205 down DSVVAGFQWATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSVVAGFQWATK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 66842000.0 20250000.0 26198000.0 20394000.0 False True 26547946.101278942 22289360.519004185 18283824.51306167 1.0 0.8395888869885267 0.6887095688423464 24.66209691453967 -6.971865328279222 0.20888191796008002 1.0801296324990906 0.443962118992416 0.9999935059536087 0.00032385208047931594 0.07570194585618192 0.006819996402692286 0.004558509737144225 0.01567545379535737 1.0669269166104621e-07 6.971865328279222 -0.6361675135066746 DSVVAGFQWATK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSVVAGFQWATK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 67609000.0 21864000.0 13671000.0 32074000.0 False True 21169939.287748527 19129901.593323167 23672857.2006252 1.0 0.9036351655667728 1.1182298106223272 24.3355137961272 -6.7845979178066536 1.5175915293447453 0.9457617130673722 1.1201925752671882 0.7834362528577212 0.040840050613585914 0.24349582728427072 1.1078282206545207 0.02118826123626359 0.04981446355333447 1.6421093812498786e-07 6.7845979178066536 0.17443086219981596 DSVVAGFQWATK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSVVAGFQWATK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 64893000.0 34925000.0 0.0 29968000.0 False True 52983778.35950893 0.0 24044811.664559007 1.0 0.0 0.45381459022058807 25.659047392520073 -9.858587030285113 10.130207859884454 0.9999910300027757 0.22690728879332808 0.7946363966831174 0.1852690307174957 0.0 0.0 0.17938596760150724 0.05979532253383573 1.3848826350624032e-10 9.858587030285113 -0.7730837412094476 DSVVAGFQWATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSVVAGFQWATK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 57677000.0 20250000.0 15413000.0 22014000.0 False True 27736972.23567349 14732002.69602488 16814746.59256153 1.0 0.5311323301927503 0.6062214162991986 24.725306976062562 -10.708295647369138 6.816790044755527 1.0044290992795746 0.5686768732460094 0.977774670465444 0.03065499103545131 0.0020746269334045954 8.877740493098243e-05 0.029842035866856985 0.009893855813203373 1.9575116374630797e-11 10.708295647369138 -0.4357522260335652 DSVVAGFQWATK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSVVAGFQWATK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 48515000.0 21864000.0 11339000.0 15312000.0 False True 18180884.73942943 11277914.556384731 18513668.405311123 1.0 0.6203171472687454 1.0183040413407372 24.115919071561475 -11.000045357212272 12.124774739280326 1.1809183571546147 0.8193105943047277 0.21558263378306797 0.16247746913191316 0.06080942249845427 2.2748508989912815e-07 0.012039234595526313 0.05243937767348578 9.998955666127079e-12 11.000045357212272 -0.36160776284988694 DSVVAGFQWATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSVVAGFQWATK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 103767000.0 34925000.0 51338000.0 17504000.0 False True 45211100.97467271 48480995.17027103 14318451.606206875 1.0 1.0723250291433981 0.31670212176934337 25.430173714612522 -6.883421886938045 1.0604882526440156 1.0472303070608255 0.25950020336066737 0.9763441511912787 0.05236118911686766 0.12464400194032926 0.2543130810797602 0.037908403709975176 0.09252699754928766 1.307910761174555e-07 6.883421886938045 -0.7877301037001582 down DSYESYGNSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSYESYGNSR 10 0 P38159;P38159-2;Q96E39;H3BUY5 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 4367680.0 1371400.0 363080.0 2633200.0 False True 1327865.6576664078 508059.7374371869 1943485.9256932768 1.0 0.38261380923884386 1.4636163790159018 20.340677763582494 -6.751812663856876 1.6433233476195799 0.6377628442049449 1.4660429478470163 0.65667780306329 0.2594548149322531 0.2968839943759978 1.5779918670089637 0.12469829348048052 0.3021376150603427 1.770872672639121e-07 6.751812663856876 0.8282801036420714 DSYLILETLPTEYDSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSYLILETLPTEYDSR 16 0 E9PMD8;E9PLG2;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 0 6829000.0 1393400.0 2141400.0 3294200.0 False True 1826760.893704793 1821911.4671118243 2953347.784197697 1.0 0.9973453413582039 1.6167128354757532 20.800856380059557 -6.905935658974086 0.9229797515456591 0.9782718386409037 1.690166334368752 0.9892948830180966 0.03014457382346334 0.10716741679967445 0.15380507433612314 0.024194108711925906 0.06504680395601421 1.24183627286192e-07 6.905935658974086 0.7118944957278484 DSYLILETLPTEYDSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSYLILETLPTEYDSR 16 0 E9PMD8;E9PLG2;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 0 6585200.0 1393400.0 1529700.0 3662100.0 False True 1908577.6352191318 1462112.7959585588 2797187.4033169653 1.0 0.766074572486902 1.465587436266803 20.864066441582448 -6.816574937471675 1.3870026566218892 0.8734648247984014 1.4797188423279621 0.8762294856413883 0.10228824747894112 0.19797888742135375 0.7493470312525387 0.057970976923568486 0.1337269868056142 1.5255451394266343e-07 6.816574937471675 0.6062540175295608 DSYSGGVVNMYHMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSYSGGVVNMYHMK 14 0 X5D2R7;P28062-2;P28062;Q5JNW7;A0A140T998 X5D2R7 PSM8;PSMB8 Proteasome subunit beta type;Proteasome subunit beta type-8 0 10584300.0 1972400.0 4141900.0 4470000.0 False True 2585835.5007487684 3523944.6649997514 4007487.2792677116 1.0 1.3627876421293386 1.549784306893181 21.302199069606715 -11.282055187694505 0.11483224367013181 1.0973351536348863e-17 1.929091594091372 0.9998174135915051 0.0030840899902162323 3.897080002793232 0.07317779401612735 1.2643391014665264 0.2620841849055529 5.223298100539546e-12 11.282055187694505 1.929091594091372 DSYSGGVVNMYHMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSYSGGVVNMYHMK 14 0 X5D2R7;P28062-2;P28062;Q5JNW7;A0A140T998 X5D2R7 PSM8;PSMB8 Proteasome subunit beta type;Proteasome subunit beta type-8 0 7068000.0 1972400.0 3130200.0 1965400.0 False True 2701649.582105796 2991897.4138128264 1501212.998683587 1.0 1.107433559714579 0.5556653270752713 21.365409131129606 -6.856193568179457 1.2048101989830917 1.0577959623215305 0.5308232429023808 0.9488465416304777 0.054019939722513226 0.15077225470982333 0.41805342677788004 0.03502065314188326 0.08143000941486248 1.3925360012794042e-07 6.856193568179457 -0.5269727194191497 DSYVGDEAQSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSYVGDEAQSK 11 0 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 305388100.0 8058100.0 146730000.0 150600000.0 False True 10564247.134751404 124838455.94906025 135017356.65720752 1.0 11.817070762988916 12.780594294605617 23.33268662091531 -9.519063280668188 0.7117534899357025 5.532043155454212e-21 12.619484300183132 0.9992088294553988 0.15022543919002943 0.8506840183216355 0.34461763325096056 2.6414581873549086 0.14774186754043483 3.026472411330422e-10 9.519063280668188 12.619484300183132 DSYVGDEAQSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSYVGDEAQSK 11 0 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 267417000.0 81586000.0 28261000.0 157570000.0 False True 78996097.08791861 39545764.67916804 116297690.00132543 1.0 0.5006040315530479 1.4721953905126737 26.23527804090635 -6.767015759957162 1.5861083022836902 0.7124668316320104 1.4770250892119687 0.7189333291127522 0.2103145973932195 0.2712814867634244 1.3464514940829657 0.10455098896820042 0.2495389568384867 1.70995326208189e-07 6.767015759957162 0.7645582575799583 DSYVGDEAQSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSYVGDEAQSK 11 0 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 1019204900.0 7023800.0 1007900000.0 4281100.0 False True 10655618.108561747 828032370.2413574 3434938.7085272153 1.0 77.70852538118241 0.3223594045442803 23.345110947270424 -13.9999831241131 1.6913439278812942e-22 9.53366398219102 60.89413232496821 0.0 37.38896292736612 0.0 0.2695237595355833 53.67709260686079 53.67709889834176 1.000038858920594e-14 13.9999831241131 51.36046834277719 DSYVGDEAQSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSYVGDEAQSK 11 0 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 287488100.0 8058100.0 137540000.0 141890000.0 False True 11037397.331964476 131463028.01604232 108378504.31627879 1.0 11.910690904940363 9.819208374642175 23.395896682438202 -9.76563419935179 9.20141390769112 1.0000309411459312 10.864949639791265 0.9673877629305305 0.853844167716142 0.0 0.0 0.8267311096462894 0.27557702012359986 1.7154015598242168e-10 9.76563419935179 9.864918698645333 DSYVGDEAQSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSYVGDEAQSK 11 0 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 23893400.0 7023800.0 10104000.0 6765600.0 False True 9092447.559796888 9541703.517870178 5534330.220918271 1.0 1.0494097936907238 0.6086733175552017 23.116237269362873 -6.879052977585004 1.0850206158334392 1.030259354878274 0.5779945671214105 0.972915540127177 0.03244630202159549 0.12847443987788051 0.2773573341813661 0.023054148463130957 0.055621309327697356 1.3211344652437625e-07 6.879052977585004 -0.4522647877568634 DSYVGDEAQSK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSYVGDEAQSKR 12 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 127059000.0 37987700.0 38591300.0 50480000.0 True False 49802242.57341006 32833628.467709206 45256813.838352144 1.0 0.6592801201534533 0.9087304406351219 25.56970737190034 -10.499156709037836 5.319094403659447 1.0004681773381225 0.7840052803942863 0.4999176083381912 0.10183766689230844 0.0005666101531227433 5.335168235319893e-05 0.09881437276111163 0.03286796565754343 3.168423975650974e-11 10.499156709037836 -0.21646289694383625 DSYVGDEAQSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSYVGDEAQSKR 12 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 228186000.0 58357000.0 59418000.0 110411000.0 True False 56504488.97800678 83143917.2607767 81491046.8409998 1.0 1.4714568482008354 1.4422048285883715 25.751862150660628 -10.164534929434001 4.892600363514157 0.9999627435603318 1.456830838395106 0.9969343060873038 0.011942087004290025 4.864257663084066e-06 8.30611189539584e-07 0.011563818890011943 0.0038542920065171727 6.846444162996746e-11 10.164534929434001 0.4568680948347743 DSYVGDEAQSK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DSYVGDEAQSKR 12 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 543767400.0 89312000.0 104347000.0 350108400.0 True False 135492833.58180264 85725462.58316788 280909321.2820372 1.0 0.6326937028105761 2.07324117339712 27.01364130640195 -6.83908488301104 1.2866443070330744 0.8045734111659482 2.119769231193954 0.922870519893218 0.1697398319302778 0.16986831608487454 0.5466480872310222 0.10346189980884148 0.2383001294477593 1.4484887182407622e-07 6.83908488301104 1.3151958200280058 up DSYVGDEAQSK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSYVGDEAQSKR 12 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 146741600.0 37987700.0 38807900.0 69946000.0 True False 52032779.26899227 37093238.6574362 53426195.38308852 1.0 0.7128821327355285 1.0267795826721604 25.63291743342323 -6.666049769996661 1.9511004453442156 0.816121058649681 1.025499944230184 0.26182890831017647 0.12207235027290585 0.47022365149580303 3.4470344210358825 0.050434688017331794 0.1354603451926972 2.1574971465618041e-07 6.666049769996661 0.209378885580503 DSYVGDEAQSK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DSYVGDEAQSKR 12 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 218265000.0 58357000.0 81530000.0 78378000.0 True False 48526431.153443225 81090781.707562 94766477.42107333 1.0 1.6710641969764584 1.9528837206555858 25.532267426094904 -10.521828246109976 0.18425143395099025 6.111048041282416e-17 2.2280909729027973 0.999479487425511 0.009118721741586584 2.295793203452323 0.09542571769778199 1.2372775085355432 0.19415054198117213 3.007265374622794e-11 10.521828246109976 2.2280909729027973 DSYVGDEAQSK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DSYVGDEAQSKR 12 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 513622000.0 89312000.0 121420000.0 302890000.0 True False 115616144.60271913 114662870.26324186 247767127.91384858 1.0 0.9917548336977252 2.1430149635695552 26.7847676284944 -6.905286584283931 0.927243070542345 0.9588267023752676 2.277716411298488 0.9890178025745757 0.05667118221004778 0.10761782799357197 0.1562876567233192 0.0453422286766185 0.12143070947098317 1.2436936465210638e-07 6.905286584283931 1.3188897089232205 up DSYVGDEAQSKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DSYVGDEAQSKR 12 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 25417140.0 727340.0 7232800.0 17457000.0 False True 953549.7835705801 6153694.433233584 15650717.099368347 1.0 6.453459000526425 16.41310959220611 19.862948736137383 -6.961782037499622 0.40954570606023644 0.5069431607617948 22.728964720791843 0.9998306876780888 0.08303463995478469 0.07907058739776117 0.01882372308371585 0.12823303821709797 0.8316789062134005 1.0919882429527573e-07 6.961782037499622 22.222021560030047 DSYVGDEAQSKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DSYVGDEAQSKR 12 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 5906380.0 1996400.0 607480.0 3302500.0 False True 1933025.3747741117 850049.9319663505 2437476.1771236723 1.0 0.43975104675782395 1.2609643975359142 20.882429145218122 -6.723010732875015 1.7482510845725803 0.6602595669593673 1.2599277310155146 0.5268055599054816 0.23567154068340063 0.34949257758603586 2.089097742754851 0.10696519277872288 0.26759984540151316 1.89229685305751e-07 6.723010732875015 0.5996681640561473 DSYVGDEAQSKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DSYVGDEAQSKR 12 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 30912740.0 727340.0 25841000.0 4344400.0 False True 996257.2536244335 24699259.17524032 3318342.195726559 1.0 24.792049528756937 3.3308085674199757 19.926158797660275 -6.285265595904015 4.173554302846938 9.999999999999998 2.9470759630115304 0.1285359223751028 9.996776742018303 0.8610099396255598 30.853683952382994 3.911647408793133 17.086746500863264 5.184828600420942e-07 6.285265595904015 -7.052924036988468 DTAK(ub)SLQPLAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTAKSLQPLAPR 12 1 Q14764 Q14764 MVP Major vault protein 1 13993090.0 3910300.0 5901200.0 4181590.0 True False 5126441.167399065 5020763.962697435 3748919.179443638 1.0 0.9793858543869244 0.7312907838062009 22.289526207655502 -6.92335147623266 0.7994765674090919 1.0048414553647176 0.688027448760199 0.9950623842348478 0.008579903441784525 0.09623976485242693 0.09568831220249652 0.007526838385931342 0.023322503762200637 1.1930221961037815e-07 6.92335147623266 -0.31681400660451864 DTAK(ub)SLQPLAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTAKSLQPLAPR 12 1 Q14764 Q14764 MVP Major vault protein 1 30216000.0 8243000.0 6609800.0 15363200.0 True False 7981330.476990078 9249127.609651636 11339117.033879308 1.0 1.1588453374179377 1.4207051150894732 22.928197831130188 -6.963641228761655 0.38065956874983103 0.9821456120272521 1.6066744648807663 0.99988232629216 0.0018816415033594046 0.07842520770265603 0.016505206704790318 0.003405570518049971 0.022119922771687648 1.0873234920568303e-07 6.963641228761655 0.6245288528535141 DTAK(ub)SLQPLAPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DTAKSLQPLAPR 12 1 Q14764 Q14764 MVP Major vault protein 1 66521600.0 16855000.0 26506200.0 23160400.0 True False 25570267.265555386 21775961.516114127 18582736.788436078 1.0 0.8516125893391656 0.7267322079761007 24.607963904207455 -6.973117365500617 0.16775678825048757 1.113724651194428 0.4612828987093912 0.9999976057028532 0.00017274057570774065 0.07530341549059409 0.005220254126077845 0.005372900290963832 0.014578615742211365 1.0638554787576674e-07 6.973117365500617 -0.6524417524850369 DTAK(ub)SLQPLAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DTAKSLQPLAPR 12 1 Q14764 Q14764 MVP Major vault protein 1 14095350.0 3910300.0 3992450.0 6192600.0 True False 5356043.581884151 3816050.357733381 4730035.420600378 1.0 0.7124755987125424 0.8831211599171573 22.352736269178394 -10.26092440293698 5.372106382085728 1.0000216466684035 0.797798379778074 0.6518169403873448 0.06966575863708957 1.8063594437912345e-05 2.4851648099426897e-06 0.06746079738379092 0.022484526916854257 5.483724110699898e-11 10.26092440293698 -0.20222326689032954 DTAK(ub)SLQPLAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DTAKSLQPLAPR 12 1 Q14764 Q14764 MVP Major vault protein 1 24131000.0 8243000.0 10494300.0 5393700.0 True False 6854419.726816536 10437765.122944541 6521497.732348916 1.0 1.5227788111820595 0.951429587370448 22.708603106564464 -6.666027633441529 1.9515937838766795 1.3348232357126941 0.9537816174597317 0.2615154993648592 0.22227087707272225 0.47030180316289766 3.4494570277133794 0.09181847824546886 0.24658123914702298 2.1576071198028336e-07 6.666027633441529 -0.38104161825296246 DTAK(ub)SLQPLAPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DTAKSLQPLAPR 12 1 Q14764 Q14764 MVP Major vault protein 1 58059000.0 16855000.0 23055000.0 18149000.0 True False 21819129.76172105 21771968.98302623 14846068.22446577 1.0 0.9978385582188728 0.6804152313403146 24.379090226299905 -6.908393477162431 0.9066074611237084 1.0103343547497887 0.6407728515374639 0.9903010113293377 0.014786976832237604 0.10548991932341059 0.14460153146207275 0.012010944176862645 0.03279786573953348 1.2348281540831659e-07 6.908393477162431 -0.36956150321232484 DTALETALNAK(ub)AYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTALETALNAKAYK 14 1 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8Y4C5;A0A2R8YGP5 P51532 SMARCA4 Transcription activator BRG1 1 5514000.0 1332300.0 2211400.0 1970300.0 True False 1290006.8657641497 3094423.552298653 1454219.3222670015 1.0 2.3987651805757153 1.1272958004030302 20.2989473134049 -6.623371296545114 2.1041125614713843 1.9258994580103186 1.1322082690069344 0.09433361323393741 0.6009976153174468 0.5764185831584333 4.853809474558433 0.23430283937747715 0.6662854969965907 2.3802835950504255e-07 6.623371296545114 -0.7936911890033842 DTDEADLVLAK(ub)EANVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTDEADLVLAKEANVK 16 1 P45973 P45973 CBX5 Chromobox protein homolog 5 1 17905900.0 8445300.0 7826400.0 1634200.0 True False 11071870.084401542 6658731.627068258 1465108.6603533102 1.0 0.6014098410032217 0.13232711810965062 23.400395584039305 -7.6155835902413 0.4542956407525416 1.0261652588247123 2.039796365098126e-18 0.9974907664117558 0.017763484247563105 0.1188189613925789 0.07048531144209187 0.024663219131159483 0.07276687175172367 2.4233514883733486e-08 7.6155835902413 -1.0261652588247123 down DTDEADLVLAK(ub)EANVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTDEADLVLAKEANVK 16 1 P45973 P45973 CBX5 Chromobox protein homolog 5 1 19578900.0 10174400.0 9404500.0 0.0 True False 9851419.241184996 13159765.893819619 0.0 1.0 1.3358243692242533 0.0 23.23190015021033 -6.873261087812694 1.3544041089882966 1.1759091289383292 4.2290157680843073e-20 0.9235844926766875 0.1568408148039916 0.15420494041697763 0.568737835120502 0.09374498708030492 0.1925373032909192 1.3388715467808848e-07 6.873261087812694 -1.1759091289383292 down DTDEADLVLAK(ub)EANVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DTDEADLVLAKEANVK 16 1 P45973 P45973 CBX5 Chromobox protein homolog 5 1 18100100.0 8445300.0 7915400.0 1739400.0 True False 11567755.635651039 7565671.455272521 1328589.5440674834 1.0 0.654031057844586 0.1148528362729984 23.463605645562197 -7.452208350005238 0.5268731268958705 1.0094581174660888 3.1762629691888943e-22 0.9968139298390799 0.020558391337066384 0.1131004673196667 0.07123522349071995 0.021701724858255795 0.06693775063749458 3.5301377305765484e-08 7.452208350005238 -1.0094581174660888 down DTDEADLVLAK(ub)EANVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DTDEADLVLAKEANVK 16 1 P45973 P45973 CBX5 Chromobox protein homolog 5 1 24857800.0 10174400.0 12120900.0 2562500.0 True False 8460464.402344078 12055602.305889735 3098306.9023386766 1.0 1.4249338727256602 0.3662100276056066 23.012305425644605 -6.797801730547506 1.4651226908332988 1.235116266588076 0.35241908910847547 0.8255706046886779 0.18168356042500466 0.22392191632146036 0.94920748440566 0.09757035254154509 0.22719799779999147 1.592935787691357e-07 6.797801730547506 -0.8826971774796004 down DTDPDSKPFSLQETYEAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DTDPDSKPFSLQETYEAKR 19 2 D6RDU5;D6RGI3;D6RER5;Q9NVA2;Q9NVA2-2;H0Y961;Q14141;B1AMS2;Q14141-2;Q14141-4 D6RDU5;Q14141 SEPT11;SEPT6 Septin-11;Septin-6 1 16441500.0 3442000.0 4368400.0 8631100.0 True False 4455736.851963444 4125294.699867786 7060328.362564685 1.0 0.9258389435744961 1.5845478754997648 22.087232601468536 -6.878925171665092 1.0857393377560767 0.9546543238829345 1.6302853510082178 0.9728096877561005 0.048577746275824 0.12858815387264885 0.27805503032689066 0.03449726516984148 0.08320268654884981 1.321523311199407e-07 6.878925171665092 0.6756310271252833 DTDSEEEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTDSEEEIR 9 0 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 0 28217670.0 690670.0 16027000.0 11500000.0 False True 905475.0584577947 13635834.072756702 10310090.31578941 1.0 15.059314936825821 11.386387973346896 19.78831537675546 -9.62340663089119 9.73516142430176 1.0000530611052671 13.222851455086358 0.936571872347814 1.499466154151842 0.0 0.0 1.4518518822996698 0.4839506202221795 2.38008994224924e-10 9.62340663089119 12.22279839398109 DTDSEEEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTDSEEEIR 9 0 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 0 26034900.0 7381300.0 2705600.0 15948000.0 False True 7146984.671819347 3785960.1895176102 11770740.370255368 1.0 0.5297283208743542 1.646951953971239 22.76890326344415 -6.792354890114983 1.4868584407117296 0.7379622601256444 1.6596250413405087 0.8088649803338809 0.20023377161422776 0.23186689438119937 1.0125791720900363 0.10598471786740406 0.24772300505231354 1.6130398988731501e-07 6.792354890114983 0.9216627812148643 DTDSEEEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DTDSEEEIR 9 0 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 0 30405670.0 690670.0 16919000.0 12796000.0 False True 946029.3636549445 16171462.63634885 9773848.341892323 1.0 17.09403878741257 10.331442888972783 19.85152543827835 -9.543947980278901 7.8584279013567615 1.000217266327049 13.712740838193726 0.8249249729593556 2.7608182174894744 0.0 0.0 2.6731505839737806 0.8910502477571207 2.857932845596899e-10 9.543947980278901 12.712523571866678 DTDSINLYK(ub)NMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 DTDSINLYKNMR 12 1 O14980 O14980 XPO1 Exportin-1 1 26911100.0 6931900.0 9446500.0 10532700.0 True False 9087788.02861508 8037119.022168604 9442877.240792632 1.0 0.8843867173025831 1.0390732278371226 23.11549775389913 -6.706652929783313 1.807283132368731 0.9286814786691401 1.03867300279035 0.4491459019621957 0.04874507668200054 0.38183256467806154 2.4290308408964574 0.021481584570560736 0.05479295736200898 1.9649299404182052e-07 6.706652929783313 0.10999152412120983 DTDSINLYK(ub)NMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 DTDSINLYKNMR 12 1 O14980 O14980 XPO1 Exportin-1 1 36129330.0 8154600.0 8049930.0 19924800.0 True False 7895736.686602365 11264309.028830389 14705897.148812622 1.0 1.4266317983911343 1.862511090797375 22.912642447762458 -6.970857445813127 0.23681242757249485 0.8371687389335855 2.4645319142628206 0.9999883194640871 0.0012034381370676407 0.0760254452685067 0.00802786793108538 0.010658504337271823 0.04273901157329426 1.069405846757265e-07 6.970857445813127 1.627363175329235 DTDSINLYK(ub)NMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 DTDSINLYKNMR 12 1 O14980 O14980 XPO1 Exportin-1 1 184967900.0 22469700.0 94623200.0 67875000.0 True False 34088177.655108325 77736950.66556396 54459476.49933067 1.0 2.2804666020013715 1.5976059808867364 25.022768139658538 -10.285525729825652 5.386937813028987 0.9998669993037256 1.9390362914441073 0.7160209150955684 0.2787766811953284 0.00044536344909030466 5.906842297109461e-05 0.26996184179400756 0.08997478696501304 5.1817239191591254e-11 10.285525729825652 0.9391692921403817 DTDSINLYK(ub)NMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DTDSINLYKNMR 12 1 O14980 O14980 XPO1 Exportin-1 1 38571800.0 6931900.0 7499000.0 24140900.0 True False 9494810.757553825 7167669.38412319 18439316.61744205 1.0 0.7549038698239223 1.942041509650122 23.178707815422023 -6.852867168275999 1.2211373138808335 0.8688126167384328 1.9922001536978093 0.9443811014861514 0.12068470454364227 0.1543291427381081 0.44140588599424446 0.07727259233656146 0.17917650916791533 1.4032428296599163e-07 6.852867168275999 1.1233875369593767 DTDSINLYK(ub)NMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DTDSINLYKNMR 12 1 O14980 O14980 XPO1 Exportin-1 1 47912800.0 8154600.0 14353300.0 25404900.0 True False 6780911.210032527 14275975.923993034 30716947.131014183 1.0 2.1053182207829786 4.529914369851605 22.693047723196734 -6.958198482879707 0.46011990024197175 0.9294119174090151 5.803580566751481 0.9996974396469925 0.025643472347842446 0.08035103295858682 0.023557340935707893 0.03293547172963986 0.2002933948948105 1.1010359949705203e-07 6.958198482879707 4.874168649342465 DTDSINLYK(ub)NMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DTDSINLYKNMR 12 1 O14980 O14980 XPO1 Exportin-1 1 121206700.0 22469700.0 52019100.0 46717900.0 True False 29087469.594004404 49124191.35653603 38215721.566134185 1.0 1.6888437544481922 1.3138207654202867 24.793894461750988 -10.275532533413086 4.904337695579105 0.9998596887330722 1.5013322599346492 0.7043805053079686 0.1531024941567069 0.0002349509044232168 3.470717736035155e-05 0.14828196425338394 0.049413617510776636 5.302338708173898e-11 10.275532533413086 0.5014725712015771 DTEDGLK(ub)AVITCYDTETR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTEDGLKAVITCYDTETR 18 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 41505000.0 10964000.0 15732000.0 14809000.0 True False 14373910.175527027 13384846.922855705 13276706.737958746 1.0 0.9311903830903787 0.9236670172437577 23.776949239818734 -13.999999999406866 0.3125481674154474 1.6751456411296253 0.9220459971998923 0.9996775550144718 0.0006167522052447148 17.453276377134838 0.17797997190708323 7.674060699765564 0.0025802070739626955 1.0000000013657424e-14 13.999999999406866 -0.7530996439297329 DTEDGLK(ub)AVITCYDTETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTEDGLKAVITCYDTETR 18 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 23286400.0 9988800.0 8616600.0 4681000.0 True False 9671711.011592688 12057253.31497538 3454905.673010119 1.0 1.2466515284134667 0.357217628697653 23.20533970717312 -6.832721183308728 1.315640673258032 1.1315671501067206 0.33191374933868606 0.911221841428175 0.11171051027814309 0.17747523980445587 0.5998118931766261 0.06664694459116725 0.15337893730365976 1.4698696298590743e-07 6.832721183308728 -0.7996534007680345 down DTEDGLK(ub)AVITCYDTETR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DTEDGLKAVITCYDTETR 18 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 70794000.0 25676000.0 31684000.0 13434000.0 True False 38952369.16703654 26029742.651778094 10778764.011668619 1.0 0.668245429184466 0.2767165192301102 25.215207742988543 -7.285253256772898 0.33754461830406035 1.0550175864539455 2.339463505007744e-14 0.9997808509164201 0.004376190039132141 0.10146987362724467 0.02392789634730507 0.011806230723070622 0.048718736725955766 5.1849759133420994e-08 7.285253256772898 -1.0550175864539222 down DTEDGLK(ub)AVITCYDTETR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DTEDGLKAVITCYDTETR 18 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 44007000.0 10964000.0 15437000.0 17606000.0 True False 15017687.090959216 14754942.296667496 13447825.406951874 1.0 0.9825043102376334 0.8954658147756713 23.840159301341625 -6.939920676313872 0.6603295795623503 1.0009783479603214 0.8720512061648594 0.998153104781149 0.001964640548887275 0.08780350183375199 0.0547806587977175 0.0019112441810910487 0.007493885620682749 1.1483633503773408e-07 6.939920676313872 -0.12892714179546194 DTEDGLK(ub)AVITCYDTETR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DTEDGLKAVITCYDTETR 18 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 36151000.0 9988800.0 4190200.0 21972000.0 True False 8306129.778869956 4167626.5609104224 26566243.612950362 1.0 0.5017531235199922 3.1983901432087527 22.985744982607397 -6.858998716731039 1.1908496402494837 0.7303762223950269 3.3264598014923332 0.9524078740779274 0.25558353744596807 0.14783308754715294 0.39894702980073027 0.16746770403332834 0.3904728794290362 1.3835704671895392e-07 6.858998716731039 2.5960835790973062 up DTEDGLK(ub)AVITCYDTETR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DTEDGLKAVITCYDTETR 18 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 50340000.0 25676000.0 24664000.0 0.0 True False 33238088.14962624 23291426.71860153 0.0 1.0 0.7007450793725463 0.0 24.986334065080992 -7.427197044831684 0.7477267277314165 0.9910310871754262 8.513933614730171e-18 0.9873171228723197 0.047195243930898974 0.11508823225185144 0.13978948126790494 0.04106945364413199 0.0738163277049467 3.7394088812518186e-08 7.427197044831684 -0.9910310871754262 down DTEPTNFK(ub)VAAGTLDASTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTEPTNFKVAAGTLDASTK 19 1 E9PHA2;Q15003;Q15003-2;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 1 8075300.0 4097600.0 3977700.0 0.0 True False 3967523.9309128365 5566016.353431464 0.0 1.0 1.4028942106849123 0.0 21.919807494314096 -6.8571384959300135 1.3899581563342844 1.2131923766017312 5.408006274447425e-22 0.9048166581164564 0.18195400863516228 0.16801455955927033 0.6525052558393466 0.10546677208528032 0.2208438042670498 1.3895094478454377e-07 6.8571384959300135 -1.2131923766017312 down DTEPTNFK(ub)VAAGTLDASTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DTEPTNFKVAAGTLDASTK 19 1 E9PHA2;Q15003;Q15003-2;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 1 11288200.0 4097600.0 4913200.0 2277400.0 True False 3407335.954458742 4886731.616406153 2753593.810492133 1.0 1.4341795707028877 0.8081368691833452 21.700212769748372 -6.72019002221249 1.7587874185265164 1.2641027758603827 0.8091146676313947 0.5133011989961604 0.18270079047077703 0.35497040330056157 2.1460686283524284 0.08248051675593444 0.20699849253770417 1.9046271806390436e-07 6.72019002221249 -0.45498810822898794 DTFNGNLPFLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTFNGNLPFLFK 12 0 P34949;P34949-2;H3BPB8;F5GX71;H3BPP3;H3BUZ9;H3BP57;H3BMZ9;H3BN01;H3BQX0;H3BT48;H3BPU7;H3BT46;H3BNY8;H3BPM5;B4DYB8 P34949 MPI Mannose-6-phosphate isomerase 0 3867180.0 766880.0 1822800.0 1277500.0 False True 1005387.106476483 1550845.345218751 1145316.5546453034 1.0 1.5425355420101827 1.139179672453949 19.939319661837196 -10.752901490590254 6.684793030483861 0.9924007526603024 1.3408576072320415 0.48774576859243624 0.1646693441948974 0.01880835936263852 0.00069523669816127 0.1607963367892993 0.05314680230814456 1.7664384499427734e-11 10.752901490590254 0.34845685457173914 DTFNGNLPFLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DTFNGNLPFLFK 12 0 P34949;P34949-2;H3BPB8;F5GX71;H3BPP3;H3BUZ9;H3BP57;H3BMZ9;H3BN01;H3BQX0;H3BT48;H3BPU7;H3BT46;H3BNY8;H3BPM5;B4DYB8 P34949 MPI Mannose-6-phosphate isomerase 0 3851580.0 766880.0 1278700.0 1806000.0 False True 1050416.2601527541 1222202.8059045621 1379459.9957375373 1.0 1.1635413999844466 1.3132508016745026 20.002529723360087 -6.972181385428507 0.19931361511239987 0.9100963239015732 1.5708262709739282 0.9999947696268768 0.0002925091162116111 0.07560105318236757 0.0064301282979046005 0.004888144105767366 0.015921191831647086 1.0661507446313632e-07 6.972181385428507 0.660729947072355 DTGIFLDLMHLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 DTGIFLDLMHLK 12 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 60542110.0 16335610.0 23417000.0 20789500.0 False True 21416142.90427228 19923274.878751054 18638401.966965586 1.0 0.9302923952182157 0.8702968620576133 24.352195335058425 -6.9728741528408404 0.1765057908169987 1.0485839460345552 0.7503885050446758 0.999996982528792 9.188534766241077e-05 0.07538059411031249 0.005544748748938155 0.002383381712747949 0.006805930765440636 1.0644514236644061e-07 6.9728741528408404 -0.2981954409898794 DTGIFLDLMHLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 DTGIFLDLMHLK 12 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 111708500.0 39128900.0 25123200.0 47456400.0 False True 37886774.48757697 35155024.77575721 35026145.178516865 1.0 0.9278970102689661 0.9244953061391357 25.17519098461087 -13.999999999928619 0.43596873533169384 2.535036180702752 0.9244503327639564 0.9998825446909768 0.0003773148623717963 32.8878141363301 0.2225546995542394 48.34076673795851 0.0007936292393883596 1.000000000164361e-14 13.999999999928619 -1.6105858479387958 DTGIFLDLMHLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 DTGIFLDLMHLK 12 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 222810600.0 43650100.0 107543000.0 71617500.0 False True 66220392.949760936 88351111.41270588 57462269.73393464 1.0 1.3341979332519929 0.8677428081335794 25.98077223587954 -6.71438207322217 1.779516093068334 1.204529886317013 0.8686873131019748 0.48592409491518473 0.1407366622128152 0.3663315510039494 2.2639015670804987 0.06287328112943728 0.1588887753946333 1.9302694035181515e-07 6.71438207322217 -0.3358425732150383 DTGIFLDLMHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 DTGIFLDLMHLK 12 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 132532620.0 16335610.0 48159840.0 68037170.0 False True 22375326.470261265 46031979.02550621 51968191.71550059 1.0 2.0572651347316286 2.322566858837604 24.415405396581317 -10.492627578801939 0.29326813351957337 2.1808483673881954e-17 2.4132173202858938 0.9990804935545855 0.017323514516419437 2.0661073770876013 0.14231444634452725 1.6320430419124683 0.09782908431351008 3.2164175357161714e-11 10.492627578801939 2.4132173202858938 DTGIFLDLMHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DTGIFLDLMHLK 12 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 80554200.0 39128900.0 17015500.0 24409800.0 False True 32537414.054183118 16923834.124187686 29513776.321836673 1.0 0.5201345778741104 0.9070719717519249 24.955596260045148 -9.939022761894387 6.795879471696985 1.000000017647965 0.7136032748130161 0.4221172823685133 0.15796652956716792 4.219344799257187e-08 6.372044675469305e-09 0.1529504436844971 0.05098347818931744 1.1507400756971406e-10 9.939022761894387 -0.286396742834949 DTGIFLDLMHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DTGIFLDLMHLK 12 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 148811100.0 43650100.0 53848700.0 51312300.0 False True 56505914.922106266 50851972.50818837 41973987.9086591 1.0 0.8999406978594738 0.7428246753728435 25.75189855797199 -6.964485798328997 0.3667730202947976 1.0125331175684271 0.6247909177712945 0.9999021436883477 0.0010470691211326559 0.07813590412068501 0.015478031589656402 0.002081633265617091 0.013367319200482078 1.0852110360567626e-07 6.964485798328997 -0.38774219979713265 DTGK(ub)TPVEPEVAIHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTGKTPVEPEVAIHR 15 1 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 1 2339861900.0 707549900.0 1273938800.0 358373200.0 True False 927604770.8229785 1083872096.8145502 321292179.0224749 1.0 1.1684632624872444 0.3463675361839955 29.78893499911834 -6.853306406890342 1.2190182562312657 1.0902196366863288 0.3113439209935474 0.9449826696309873 0.08316631538005127 0.15385570264169884 0.4383008059365343 0.053336257627212426 0.1237137678319229 1.4018243293584156e-07 6.853306406890342 -0.7788757156927815 down DTGK(ub)TPVEPEVAIHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTGKTPVEPEVAIHR 15 1 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 1 2762770600.0 1054037100.0 1098200300.0 610533200.0 True False 1020577269.2112386 1536717406.8289075 450616239.316603 1.0 1.5057335227704727 0.4415307423659018 29.92673826877999 -6.777482671992979 1.5458071933679631 1.2872895079325453 0.4337693775160873 0.758369148196703 0.2136498673003771 0.2544873531103378 1.2009568507538686 0.10888263822014038 0.2574494889382432 1.6692344070176534e-07 6.777482671992979 -0.8535201304164579 down DTGK(ub)TPVEPEVAIHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DTGKTPVEPEVAIHR 15 1 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 1 5652191000.0 3428357000.0 1228160700.0 995673300.0 True False 5201068215.4694395 1008985827.4216532 798878035.83589 1.0 0.19399588423405897 0.15359883830398574 32.276160813949616 -13.371187793559459 0.4328016347512933 9.998660322634686 0.1528692573948322 0.9998696743670691 0.004450244574834289 18.271228693137317 0.22062415136022126 153.13810519962522 0.009497871695367073 4.2541441963028033e-14 13.371187793559459 -9.845791065239855 DTGK(ub)TPVEPEVAIHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DTGKTPVEPEVAIHR 15 1 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 1 1828033200.0 707549900.0 757278600.0 363204700.0 True False 969150218.8470895 723819527.4665512 277423230.2956 1.0 0.7468599948598411 0.28625410684591845 29.85214506064123 -6.9760781403244465 0.4118373667036824 1.0224243562598454 5.507008696214496e-12 0.9998339953292597 0.0038067882379169164 0.07703102738425133 0.018751834549506758 0.0058807758615225586 0.03745539961065709 1.0566273786966049e-07 6.9760781403244465 -1.0224243562543385 down DTGK(ub)TPVEPEVAIHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DTGKTPVEPEVAIHR 15 1 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 1 2962253000.0 1054037100.0 1758567100.0 149648800.0 True False 876478550.4108328 1749093349.9840615 180939672.1821268 1.0 1.9955917337215008 0.20643936134810684 29.707143544214265 -6.755675152174273 1.6287325833077262 1.5813978396339876 0.20126148032934463 0.6730612442304267 0.4185293252091379 0.29025036647272406 1.5164680118722331 0.20284916298296424 0.48958629895541816 1.755192877259673e-07 6.755675152174273 -1.380136359304643 DTGK(ub)TPVEPEVAIHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DTGKTPVEPEVAIHR 15 1 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 1 3987996140.0 3428357000.0 8889140.0 550750000.0 True False 4438075719.519717 8394451.544817945 450519151.1722149 1.0 0.001891461992840082 0.10151227235504885 32.04728713604207 -10.768442505750125 2.8421263792339215 1.2083654574563243 0.05170186516041607 0.9917909687533714 0.040670031928198014 20889679.991944246 17342423.30115171 30411394.58843469 0.015913764446974718 1.7043449347716335e-11 10.768442505750125 -1.1566635922959083 DTGQLYAALHHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTGQLYAALHHR 12 0 B7Z7F3;Q9H6Z4-3;Q9H6Z4-2;Q9H6Z4;K7EIJ4 B7Z7F3 RANBP3 Ran-binding protein 3 0 24330300.0 4792200.0 7609100.0 11929000.0 False True 6282620.607730819 6473851.9400395015 10694701.511048 1.0 1.0304381474306072 1.7022676011803224 22.58293503117304 -6.916375588813555 0.851167787134989 0.9831534635125376 1.8020644892493494 0.9931136348499037 0.026896488680583204 0.1003515773294068 0.11700934163216563 0.022739839075958855 0.06592597935269431 1.2123399348355416e-07 6.916375588813555 0.8189110257368117 DTINGLNK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTINGLNKQR 10 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 489646000.0 179646000.0 205089000.0 104911000.0 True False 235517645.69433895 174490520.63066083 94055816.09737238 1.0 0.7408808801405873 0.3993578307904815 27.811259914062312 -6.967317295650119 0.3157611767328585 1.0491600555601397 0.0801312666119136 0.9999532541940106 0.0016817718630156423 0.07718315171163159 0.012131605863790805 0.005268741897410155 0.030156240515108526 1.0781587313902522e-07 6.967317295650119 -0.9690287889482261 down DTINGLNK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTINGLNKQR 10 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 460799000.0 181023000.0 212381000.0 67395000.0 True False 175276523.9519805 297185840.85228366 49742227.69333832 1.0 1.6955256422913885 0.28379286952864213 27.385057537591667 -6.7727149234925985 1.5637840405455585 1.3975467056533326 0.2749720750895065 0.7409306779964513 0.2933596640099274 0.26206385674710236 1.265066486186866 0.14782644549015211 0.35105919276995806 1.6876604640073827e-07 6.7727149234925985 -1.1225746305638262 DTINGLNK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DTINGLNKQR 10 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 486910000.0 361550000.0 77656000.0 47704000.0 True False 548497782.8455389 63797680.07090269 38275283.490594 1.0 0.11631346938164124 0.0697820204341147 29.030910548033273 -13.310405152590793 0.4263863567517831 9.99999999999819 0.06857749533480854 0.9998602327093571 0.005059515405824038 16.86608694856067 0.21794971207296415 138.72686702239352 0.011113466473555786 4.893221185934849e-14 13.310405152590793 -9.93142250466338 DTINGLNK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DTINGLNKQR 10 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 432239000.0 179646000.0 163799000.0 88794000.0 True False 246065980.95060775 156561818.5691417 67822685.96983333 1.0 0.6362595022859661 0.275628047842368 27.874469975585203 -7.475818683463188 0.3052356017115767 1.0832075919345665 3.3944565546694375e-15 0.9997035671513942 0.0050915524128936395 0.12206261124839758 0.030709266987557347 0.021187316692946417 0.06331157895644135 3.3433459450053086e-08 7.475818683463188 -1.0832075919345632 down DTINGLNK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DTINGLNKQR 10 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 569371000.0 181023000.0 335950000.0 52398000.0 True False 150528645.17863765 334140170.6691462 63354179.53902115 1.0 2.2197779716452657 0.42087789645510004 27.165462813025943 -6.724102274082044 1.7445760517205364 1.738837918637278 0.4230237081505063 0.5317600352709699 0.5130473353423153 0.34742448877736604 2.0686204025957915 0.23331076511737234 0.5828855032156233 1.8875467893429025e-07 6.724102274082044 -1.3158142104867716 DTINGLNK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DTINGLNKQR 10 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 505888400.0 361550000.0 121548000.0 22790400.0 True False 468033602.2159746 114783746.95072086 18642781.04925145 1.0 0.2452468079369946 0.03983214230983509 28.802036870125722 -9.898056790734515 0.3426202278677556 1.4188488120324751 4.2485877690274807e-19 0.998592365514372 0.015488300522038112 1.323204522521738 0.1582383962362286 0.6307289830488487 0.06211708859839792 1.2645709744047142e-10 9.898056790734515 -1.4188488120324751 DTK(ub)EAIANYVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTKEAIANYVK 11 1 J3QL56;O75880 J3QL56 SCO1 Protein SCO1 homolog, mitochondrial 1 6988900.0 1596200.0 2383000.0 3009700.0 True False 1545529.5047157053 3334544.327180835 2221369.280935385 1.0 2.1575416819973374 1.43728688074706 20.559669765351902 -10.2573288581899 5.631677521214883 0.9999696867334529 1.7974142810097073 0.6203939507893963 0.29404279158494834 0.00019340424590813394 2.5505423285621432e-05 0.2847242811773892 0.09490190286514723 5.5293125785373306e-11 10.2573288581899 0.7974445942762545 DTK(ub)EAIANYVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DTKEAIANYVK 11 1 J3QL56;O75880 J3QL56 SCO1 Protein SCO1 homolog, mitochondrial 1 7446800.0 1596200.0 3725500.0 2125100.0 True False 1327311.023649709 3705429.9920461485 2569448.5846477696 1.0 2.791681773166716 1.9358300645937174 20.34007504078618 -10.132355014320062 5.698428985329222 0.9999844935496017 2.3637559188803277 0.7719726562922347 0.34939999691589624 6.883517345459541e-05 1.0480735302018266e-05 0.3383089244094011 0.11276836410162513 7.373012762896298e-11 10.132355014320062 1.363771425330726 DTK(ub)EAIANYVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DTKEAIANYVK 11 1 J3QL56;O75880 J3QL56 SCO1 Protein SCO1 homolog, mitochondrial 1 16356300.0 2947300.0 5402300.0 8006700.0 True False 3815337.949968588 5101657.255996635 6549562.755679653 1.0 1.3371442642554476 1.716640266620045 21.86337942118082 -6.969589863088091 0.2677987851731379 0.9031068447700636 2.162053073565462 0.9999790051706519 0.0013413137713179195 0.07643599064944863 0.009505226047196476 0.007540529426946169 0.03540331386362172 1.0725316993956078e-07 6.969589863088091 1.2589462287953983 DTK(ub)VVSMVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DTKVVSMVGR 10 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 3180400.0 576750.0 784650.0 1819000.0 True False 789990.0610826999 749981.5685094343 1389389.663480943 1.0 0.9493557013635932 1.758743219600449 19.591474977198832 -6.89199047731336 1.0105049082810464 0.9585631903965801 1.83114235573267 0.9821429860726956 0.04946851153892902 0.11754414997568824 0.2125193396136065 0.03719889545806329 0.09342992019481715 1.2823587003657638e-07 6.89199047731336 0.8725791653360899 DTLGLFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTLGLFLR 8 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 22700000.0 5409600.0 7146400.0 10144000.0 False True 7092037.986640914 6080184.976449013 9094396.188118933 1.0 0.8573254948580503 1.282338899657589 22.757768832998973 -6.816167773153096 1.3882128128147977 0.9227837435036524 1.2908865839674555 0.875347482236568 0.06235286385469451 0.1985299187601599 0.7527595290561847 0.03530320404021728 0.0814692661352705 1.5269760551680215e-07 6.816167773153096 0.36810284046380304 DTLGLFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTLGLFLR 8 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 13213600.0 4254300.0 2557000.0 6402300.0 False True 4119249.575186086 3578023.4345788457 4725345.565116993 1.0 0.8686105003524118 1.1471374770739708 21.97395010751759 -6.778443633478645 1.5420898480737661 0.9254531105171327 1.1492310233196907 0.7617888422677956 0.05552696760025849 0.25300208155254483 1.1882912550743758 0.028364402456680447 0.0670113555643859 1.6655449826952626e-07 6.778443633478645 0.223777912802558 DTLGLFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DTLGLFLR 8 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 13460800.0 2278500.0 5527500.0 5654800.0 False True 3456651.080662593 4541074.438445381 4537126.301413115 1.0 1.3137208044657256 1.3125786188820106 21.720943552559124 -10.088663015061089 4.754811196795191 0.9999854615979531 1.3131497116782274 0.9999900208661421 0.000466295326923664 7.18672614580663e-08 1.3774869819513178e-08 0.0004515094552118064 0.0001504961675071212 8.153366881299775e-11 10.088663015061089 0.31316425008027426 DTLGLFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DTLGLFLR 8 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 20244600.0 5409600.0 6261800.0 8573200.0 False True 7409675.308943174 5985132.970996478 6548386.730596371 1.0 0.8077456462596503 0.8837616302421156 22.820978894521865 -10.357294832936383 4.875479839029386 1.0001134276265218 0.8457536382508243 0.8459127109574394 0.031033395508972425 3.829003780093561e-05 5.047513560300303e-06 0.0300700035800707 0.010015985331847662 4.392433216023261e-11 10.357294832936383 -0.1543597893756975 DTLGLFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DTLGLFLR 8 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 10381600.0 4254300.0 2454700.0 3672600.0 False True 3537638.9474457847 2441476.0438801977 4440523.679816203 1.0 0.6901427986716878 1.255222408443437 21.754355382951868 -6.757825203640539 1.6205721527600152 0.8195280635800695 1.2570722016092193 0.6820174854133432 0.13029003794443655 0.28660842348299875 1.4829874822796223 0.06344832674555421 0.15281069997896513 1.7465249589407564e-07 6.757825203640539 0.4375441380291498 DTLGLFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DTLGLFLR 8 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 10868300.0 2278500.0 4869900.0 3719900.0 False True 2949563.165949656 4598885.784013849 3042916.3693972244 1.0 1.5591752151994238 1.0316498403984888 21.492069874651573 -10.466708675081025 3.414442506244037 0.9955768384179197 1.2954125274965949 0.2948453087645456 0.2153613340385088 83039673.23642144 76085731.4785605 3311078.3783846786 0.07881417537177017 3.414218607498616e-11 10.466708675081025 0.2998356890786752 DTLK(ub)IPYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTLKIPYK 8 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 4135860.0 433210.0 807150.0 2895500.0 True False 419457.9856771653 1129449.2042316443 2137081.6868619523 1.0 2.6926396511638275 5.0948647059654535 18.6781667871502 -6.966160882588967 0.3375356894180725 0.7318929095347989 7.135146920322601 0.9999351139174596 0.013533258655267435 0.07756920077844524 0.013482951126007814 0.03417244735751531 0.2083029468220954 1.0810334127709642e-07 6.966160882588967 6.403254010787802 DTLLALHQHGHSGPFESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTLLALHQHGHSGPFESK 18 0 Q7Z5L9;Q7Z5L9-2 Q7Z5L9 IRF2BP2 Interferon regulatory factor 2-binding protein 2 0 8457400.0 1225300.0 3073100.0 4159000.0 False True 1606380.165822081 2614605.458849979 3728666.575945062 1.0 1.6276380364245402 2.321160740948815 20.61538193069837 -6.969839500833477 0.2619904995483818 0.8099643388935907 3.159463881308604 0.9999811039351547 0.002345548066753846 0.07635481022361598 0.009216287271497913 0.014293451769894832 0.06524158628753465 1.0719153722953975e-07 6.969839500833477 2.349499542415013 DTNGENIAESLVAEGLATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTNGENIAESLVAEGLATR 19 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 6382110.0 758510.0 4147600.0 1476000.0 False True 994413.9554212891 3528794.2472181744 1323277.6787917544 1.0 3.548616979860445 1.3307110902633505 19.9234870174843 -6.61244768521134 2.1439659861326037 2.6998477497817355 1.3386654588714664 0.058291628348773106 1.0980880618746995 0.6059036348618998 5.280888890887759 0.4223528349219584 1.2191249752676239 2.4409130808985134e-07 6.61244768521134 -1.361182290910269 DTNGENIAESLVAEGLATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTNGENIAESLVAEGLATR 19 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 15172400.0 4510100.0 2561600.0 8100700.0 False True 4366929.344203927 3584460.2385675246 5978883.654209151 1.0 0.8208193804017127 1.3691276370534171 22.058187758195665 -6.818682944226736 1.3775207308016937 0.9032917647761872 1.3807671173445826 0.8813365863571139 0.07863663202484386 0.19519846614333444 0.728166398431614 0.044862993426791 0.1034422018535065 1.5181582912595078e-07 6.818682944226736 0.47747535256839535 DTNGENIAESLVAEGLATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DTNGENIAESLVAEGLATR 19 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 7710510.0 758510.0 2386000.0 4566000.0 False True 1038951.6449620106 2280578.6305531277 3487604.8397218194 1.0 2.195076779185924 3.356850009943768 19.986697079007193 -6.97147118591887 0.22022955839253622 0.4657922182834654 5.1189486600736975 0.9999916959438805 0.002772777161597478 0.07582813416778827 0.007297709280444327 0.03212374405828881 0.11769438837234268 1.067895641726005e-07 6.97147118591887 4.653156441790232 DTNGSQFFITTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTNGSQFFITTVK 13 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 694440000.0 187470000.0 201430000.0 305540000.0 False True 245774985.46206227 171377429.16799015 273925651.74663496 1.0 0.6972940262647026 1.1145383702562277 27.87276284736328 -6.712104171549386 1.7874983569401581 0.8143059956309784 1.1136287486924987 0.47516532321007177 0.12751747769180036 0.37087183428076415 2.3111689439783274 0.056740422836585605 0.14379182980192964 1.940420385050354e-07 6.712104171549386 0.29932275306152034 DTNGSQFFITTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTNGSQFFITTVK 13 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 444421000.0 121330000.0 51891000.0 271200000.0 False True 117478445.56268425 72611346.90799013 200164584.17439494 1.0 0.6180822921192476 1.7038409319741206 26.807820840720034 -6.811635190633246 1.4074863416150416 0.7922524243379172 1.72358545532506 0.8640922155640582 0.1657874000761099 0.20457832579031643 0.7984184742546764 0.09260697892025126 0.21408097439680648 1.5429960325069903e-07 6.811635190633246 0.9313330309871428 DTNGSQFFITTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DTNGSQFFITTVK 13 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 564891000.0 58448000.0 430890000.0 75553000.0 False True 88669889.12116174 353994312.94106424 60619916.43394368 1.0 3.9922719702215215 0.6836584215314675 26.4019409356979 -6.668488340746672 1.9423458373793816 2.912387600048309 0.697004788870903 0.2725176561599876 1.2714884876533354 0.46460718704645854 3.3777054526067953 0.5272263218963913 1.4115972990910455 2.1454167118069438e-07 6.668488340746672 -2.215382811177406 DTNGSQFFITTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DTNGSQFFITTVK 13 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 583690000.0 187470000.0 185650000.0 210570000.0 False True 256782725.18625715 177447369.13754752 160837702.82527855 1.0 0.6910409140990158 0.6263571769036061 27.93597290888617 -13.999999999999995 0.21978682582891185 2.8626513825495032 0.5916869517076166 0.9994976786171758 0.003654212467519592 12.993795430948976 0.1485187141554732 10.50339084369484 0.03584786761736669 1.0000000000000123e-14 13.999999999999995 -2.270964430841887 DTNGSQFFITTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DTNGSQFFITTVK 13 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 280126000.0 121330000.0 84480000.0 74316000.0 False True 100891270.83035915 84024889.47203283 89855132.0016394 1.0 0.832826158105533 0.8906135413114563 26.58822611615431 -10.354545457620956 7.753119186846497 1.0000013692221357 0.8617198507096767 0.8841883027914899 0.02359160040419837 5.583661014414999e-07 4.649339382327493e-08 0.022842694869129796 0.007614156289653386 4.420328468582044e-11 10.354545457620956 -0.13828151851245896 DTNGSQFFITTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DTNGSQFFITTVK 13 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 265466000.0 58448000.0 125990000.0 81028000.0 False True 75662088.18232405 118978545.74588905 66281735.41748928 1.0 1.572498837980584 0.8760230785300189 26.17306725779035 -6.688273753368286 1.8723217937041912 1.3594916393929288 0.878462947988752 0.36248116668722985 0.24221098326806365 0.4203778663168849 2.855766314856444 0.10353648995643008 0.27022704412074283 2.049869655793634e-07 6.688273753368286 -0.4810286914041768 DTNVMLVALAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTNVMLVALAAK 12 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 3267300.0 0.0 1490700.0 1776600.0 False True 0.0 1268293.3707030877 1592774.4743505633 0.0 DTQEVPLEK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DTQEVPLEKAK 11 1 Q9Y5A9;Q9Y5A9-2;Q9BYJ9;A0A024R7W5;A0A087X0Q1;A0A087WY31;Q7Z739 Q9Y5A9;Q9BYJ9;A0A024R7W5 YTHDF2;YTHDF1;YTHDF3 YTH domain-containing family protein 2;YTH domain-containing family protein 1;YTH domain-containing family protein 3 1 13118800.0 1801000.0 2506000.0 8811800.0 True False 2732248.6707365913 2058784.7205326343 7070143.86765085 1.0 0.7535129370115508 2.5876648576590937 21.38165736324216 -6.8730112468531965 1.1180992383406954 0.857717978901139 2.7013860456864722 0.9675944829478036 0.14631343222479948 0.13399756641641197 0.311268143965734 0.1013633855028905 0.24130823984115837 1.3396419944870006e-07 6.8730112468531965 1.8436680667853333 up DTQEVPLEK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DTQEVPLEKAK 11 1 Q9Y5A9;Q9Y5A9-2;Q9BYJ9;A0A024R7W5;A0A087X0Q1;A0A087WY31;Q7Z739 Q9Y5A9;Q9BYJ9;A0A024R7W5 YTHDF2;YTHDF1;YTHDF3 YTH domain-containing family protein 2;YTH domain-containing family protein 1;YTH domain-containing family protein 3 1 4071800.0 1195800.0 1636800.0 1239200.0 True False 994360.6829221428 1627982.233520639 1498310.99058657 1.0 1.637215008075805 1.5068083607081697 19.92340972771112 -10.158876337038238 4.611200973238317 0.9999253614474677 1.5720116843983412 0.9624816786038989 0.05323829088207346 37274477.42596992 4.195176022347964 29940.24244307105 0.0182248830200682 6.936232833096079e-11 10.158876337038238 0.5720863229508735 DTQEVPLEK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DTQEVPLEKAK 11 1 Q9Y5A9;Q9Y5A9-2;Q9BYJ9;A0A024R7W5;A0A087X0Q1;A0A087WY31;Q7Z739 Q9Y5A9;Q9BYJ9;A0A024R7W5 YTHDF2;YTHDF1;YTHDF3 YTH domain-containing family protein 2;YTH domain-containing family protein 1;YTH domain-containing family protein 3 1 15410400.0 1801000.0 2702400.0 10907000.0 True False 2331430.0030174786 2552009.0643994785 8922037.915270716 1.0 1.0946110589194242 3.8268521481336655 21.152783685334608 -6.914249311238395 0.8663023324150483 0.9263444961295344 4.214019174849647 0.9924286523464994 0.1140625058091592 0.10167454224761509 0.1240233119594476 0.09539276777149096 0.2717630443991364 1.218290026157681e-07 6.914249311238395 3.287674678720113 up DTQSGSLLFIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTQSGSLLFIGR 12 0 P50454;E9PKH2;H0YEP8 P50454 SERPINH1 Serpin H1 0 12338200.0 4342300.0 3265800.0 4730100.0 False True 5692797.3508930225 2778555.3699886925 4240674.626323094 1.0 0.4880826066209477 0.744919301520168 22.440706313693095 -10.250299162286314 4.861046431383894 1.0000869822175797 0.6165009540700527 0.7482829280986644 0.1048531416227984 9.886551386814676e-05 1.5247612061275716e-05 0.10154654639389163 0.033841205941628705 5.619540916562935e-11 10.250299162286314 -0.38358602814752707 DTQSGSLLFIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTQSGSLLFIGR 12 0 P50454;E9PKH2;H0YEP8 P50454 SERPINH1 Serpin H1 0 11608800.0 4592700.0 1572500.0 5443600.0 False True 4446907.252416877 2200407.450479169 4017757.8555005067 1.0 0.49481748225876665 0.9034948622589039 22.084370884543482 -9.965218415562154 6.918361533964663 1.0000000208616178 0.6991561722588356 0.41946075282660145 0.16684184173630967 5.3626188464036346e-08 8.00267830192554e-09 0.16154392825257408 0.05384797287460795 1.0833819221003412e-10 9.965218415562154 -0.3008438486027821 DTQSGSLLFIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DTQSGSLLFIGR 12 0 P50454;E9PKH2;H0YEP8 P50454 SERPINH1 Serpin H1 0 11847800.0 4342300.0 4116800.0 3388700.0 False True 5947765.656245193 3934906.163562915 2588358.8524672184 1.0 0.6615772024291571 0.43518171395159533 22.503916375215987 -8.256944861299045 0.14935527204672566 1.3890159037795937 3.9929796099441634e-17 0.9999273459787854 0.001978290619033347 0.0868219798777722 0.0312124535818993 0.1285823572042605 0.13148370366696718 5.5342036786375335e-09 8.256944861299045 -1.3890159037795937 down DTSASAVAVGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTSASAVAVGLK 12 0 H0YFD6;P40939;A0A2R8Y4F5 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 9939100.0 2844200.0 3265300.0 3829600.0 False True 3728773.7432719795 2778129.9680397087 3433349.728117141 1.0 0.7450519015943065 0.9207718044872292 21.830269828392655 -10.07936523683686 5.025464841766297 1.0000039475533569 0.832911853296463 0.546599999008937 0.07173734995893333 3.1729392114870196e-06 5.812358127209306e-07 0.0694610308221134 0.023153130140653434 8.329803627336099e-11 10.07936523683686 -0.16709209425689386 DTSASAVAVGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DTSASAVAVGLK 12 0 H0YFD6;P40939;A0A2R8Y4F5 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 12480500.0 2844200.0 3845500.0 5790800.0 False True 3895777.601614941 3675593.094632043 4423132.305269619 1.0 0.9434812431562768 1.1353657106699497 21.893479889915547 -6.827841013473961 1.3376686228982708 0.9697526758966889 1.1403001305863862 0.9014590862666657 0.02527332618128483 0.18349230141395256 0.6429125792221425 0.01483821020845411 0.034148891687609095 1.4864797131947983e-07 6.827841013473961 0.17054745468969734 DTSFEQHVLWHTGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTSFEQHVLWHTGGK 15 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 51710000.0 11357000.0 18866000.0 21487000.0 False True 14889136.981344454 16051266.339092009 19263731.357858032 1.0 1.0780521637488902 1.2938111444602052 23.827756797660232 -6.953274311634521 0.5216596673687479 0.9963801500524706 1.3851390923580078 0.9994338219443596 0.002956742503912673 0.08219696145976674 0.030722538521735426 0.0033408307434017923 0.017824792726527653 1.1135909385536416e-07 6.953274311634521 0.3887589423055372 DTSFEQHVLWHTGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTSFEQHVLWHTGGK 15 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 18526100.0 4533100.0 3301000.0 10692000.0 False True 4389199.2217934895 4619106.514487595 7891444.446875481 1.0 1.0523802363657948 1.797923504518194 22.065526323634426 -6.921078669853403 0.8166864295188531 0.9841811071373961 1.9211836575180739 0.9944753778025823 0.027087023727113947 0.09754115672035449 0.10235571609458594 0.02347256209076032 0.07105319033561786 1.1992820406880627e-07 6.921078669853403 0.9370025503806777 DTSFEQHVLWHTGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DTSFEQHVLWHTGGK 15 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 35745300.0 11357000.0 9333300.0 15055000.0 False True 15555989.811384892 8920923.94490424 11499319.067457704 1.0 0.5734719585876383 0.739221303619121 23.890966859183123 -10.25157573436344 5.088208528598607 1.0000534540939525 0.6563466311032405 0.8514470320745245 0.06766688675509827 4.103858297672194e-05 6.0363249146148575e-06 0.06552834585530362 0.021839393790946193 5.603047002120285e-11 10.25157573436344 -0.343706822990712 DTSFEQHVLWHTGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DTSFEQHVLWHTGGK 15 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 13117400.0 4533100.0 3693900.0 4890400.0 False True 3769473.500379965 3674000.2275182614 5912960.02934519 1.0 0.9746719872544323 1.5686434799844489 21.845931599068702 -6.896940881318455 0.9804153432211313 0.9731885739859125 1.627255717248778 0.9849811337663761 0.03360680172476702 0.11369289101339411 0.19039742253883224 0.025849562347063357 0.06628029991861663 1.267824437721143e-07 6.896940881318455 0.6540671432628655 DTSNHFHVFVGDLSPEITTEDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTSNHFHVFVGDLSPEITTEDIK 23 0 Q01085;Q01085-2;E7ETJ9;E7ETC0;A6NKZ9;P31483-2;C9JTN7;H7BY49 Q01085;P31483-2 TIAL1;TIA1 Nucleolysin TIAR;Nucleolysin TIA-1 isoform p40 0 9227800.0 3130300.0 2260300.0 3837200.0 False True 3030930.3399395924 3162849.577308788 2832122.2064675083 1.0 1.0435243382636847 0.9344068945259737 21.531329264277637 -6.798451727352136 1.462105780150326 1.0240617140959496 0.9329555226203049 0.8276312301568278 0.01862038142720368 0.22297484283617267 0.9411886501271524 0.01001933863430245 0.02332485289635301 1.5905534670044908e-07 6.798451727352136 -0.0911061914756447 DTSNHFHVFVGDLSPEITTEDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DTSNHFHVFVGDLSPEITTEDIK 23 0 Q01085;Q01085-2;E7ETJ9;E7ETC0;A6NKZ9;P31483-2;C9JTN7;H7BY49 Q01085;P31483-2 TIAL1;TIA1 Nucleolysin TIAR;Nucleolysin TIA-1 isoform p40 0 43336700.0 5836700.0 26235000.0 11265000.0 False True 8854700.61992685 21553159.275009442 9038467.812375098 1.0 2.434092376483701 1.0207536313576424 23.07801209917563 -6.642756473759062 2.0347740948429607 1.9357931933757448 1.0266629305195676 0.16543454159391835 0.613171246900198 0.526237322054092 4.167557176274754 0.2451331280900969 0.6789020901701618 2.2763735264054312e-07 6.642756473759062 -0.9091302628561773 DTSNHFHVFVGDLSPEITTEDIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DTSNHFHVFVGDLSPEITTEDIK 23 0 Q01085;Q01085-2;E7ETJ9;E7ETC0;A6NKZ9;P31483-2;C9JTN7;H7BY49 Q01085;P31483-2 TIAL1;TIA1 Nucleolysin TIAR;Nucleolysin TIA-1 isoform p40 0 7306200.0 3130300.0 2351800.0 1824100.0 False True 2602983.145802962 2339130.386604251 2205510.876314524 1.0 0.8986344726725771 0.8473012512088983 21.311734539711914 -13.999999999997478 0.08770387804403602 1.5244592372936272 0.7136814082902856 0.999853043983232 0.0007690883764700099 12.184577209636151 0.08547612281076325 1.201146194558233 0.12031387786018807 1.000000000005808e-14 13.999999999997478 -0.8107778290033416 DTSNHFHVFVGDLSPEITTEDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DTSNHFHVFVGDLSPEITTEDIK 23 0 Q01085;Q01085-2;E7ETJ9;E7ETC0;A6NKZ9;P31483-2;C9JTN7;H7BY49 Q01085;P31483-2 TIAL1;TIA1 Nucleolysin TIAR;Nucleolysin TIA-1 isoform p40 0 24003200.0 5836700.0 9466100.0 8700400.0 False True 7555723.20855753 8939303.213629333 7117016.473642736 1.0 1.1831168197777249 0.9419371616977816 22.84913842126808 -6.703654472745362 1.8174522576968906 1.1132942550728984 0.9425933394109599 0.4351468237721615 0.07724490726048991 0.3879508298996178 2.493689358885648 0.0338721377879891 0.08673181581429963 1.9785431546987742e-07 6.703654472745362 -0.17070091566193846 DTSVEGSEMVPGK(ub)VELQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DTSVEGSEMVPGKVELQEK 19 1 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 1 33262800.0 6645700.0 6670100.0 19947000.0 True False 8602989.65633163 6298903.071510872 16316850.673503708 1.0 0.7321760600833692 1.896648877346357 23.03640667249186 -6.846204570436511 1.2533889146523953 0.857424772409662 1.9398697301798786 0.9345802479133813 0.12736545878070105 0.1616828865108353 0.49071844399652637 0.0795900097549006 0.1837710055198648 1.4249362323389413e-07 6.846204570436511 1.0824449577702167 DTSVEGSEMVPGKVELQEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTSVEGSEMVPGKVELQEK 19 1 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 1 9282600.0 2509300.0 3908000.0 2865300.0 True False 2429643.645021378 5468484.779950776 2114791.972842532 1.0 2.2507353253866413 0.8704124068465705 21.21231329909725 -6.6681145236527986 1.9441468950448733 1.799626726396237 0.8760438762035782 0.2707180150869114 0.5315162379427102 0.4654390494511832 3.3898112138789998 0.22024421338689157 0.5898685292216793 2.1472641649269557e-07 6.6681145236527986 -0.923582850192659 DTTALSFFHMLNGAALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DTTALSFFHMLNGAALR 17 0 P42704 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 20183400.0 1179000.0 1879400.0 17125000.0 False True 1614908.1612769922 1796361.8936553 13080427.700445909 1.0 1.1123616418130073 8.099796641130684 20.623020691495615 -6.910392952558261 0.8930369667465451 0.786331040341913 9.010489773423044 0.9910693363372141 0.3138142857470879 0.10415944054262291 0.13735576882664627 0.25742350383825235 0.712571179953918 1.2291561188255725e-07 6.910392952558261 8.224158733081131 up DTTDK(ub)GQQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTTDKGQQLR 10 1 A0A3B3IUB1;Q13144 A0A3B3IUB1 EIF2B5 Translation initiation factor eIF-2B subunit epsilon 1 1551980.0 359300.0 457980.0 734700.0 True False 471045.7794661493 389651.1691920574 658680.2917400418 1.0 0.8272044590520715 1.3983360438693337 18.84550775210776 -6.825573685637549 1.3477074624984946 0.9073506099828389 1.4123455033046963 0.8966896138725639 0.07686643872265024 0.1863473250032548 0.6635066272020036 0.04480185599236054 0.10313400660746355 1.4942604934891264e-07 6.825573685637549 0.5049948933218574 DTTDK(ub)GQQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTTDKGQQLR 10 1 A0A3B3IUB1;Q13144 A0A3B3IUB1 EIF2B5 Translation initiation factor eIF-2B subunit epsilon 1 2191990.0 1031220.0 409750.0 751020.0 True False 998484.48556129 573365.3118180223 554305.331882943 1.0 0.5742355741218248 0.5551466646688503 19.929380485703778 DTVLGK(ub)WQYF ddPTM_RPMI8226_Bortezomib_1h_R1 1 DTVLGKWQYF 10 1 O14562;H3BRL3 O14562 UBFD1 Ubiquitin domain-containing protein UBFD1 1 94405000.0 23145000.0 43543000.0 27717000.0 True False 30343319.1364988 37046554.12928467 24849110.720237836 1.0 1.2209130439103086 0.8189318580625481 24.85487556917221 -6.757500948373372 1.6218005176832617 1.128718575497319 0.8176391849796046 0.6806790556480506 0.09288675722274203 0.28715400389830337 1.4879866409279179 0.04520134072518627 0.10889899804732897 1.7478294456607322e-07 6.757500948373372 -0.3110793905177144 DTVLGK(ub)WQYF ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTVLGKWQYF 10 1 O14562;H3BRL3 O14562 UBFD1 Ubiquitin domain-containing protein UBFD1 1 221541000.0 73781000.0 92291000.0 55469000.0 True False 71438862.54067749 129143277.5912068 40940004.865669325 1.0 1.8077454343239614 0.5730775016519611 26.09020577406614 -6.730173267501181 1.7224373894219493 1.485997477068803 0.5737655686789828 0.5601488629488993 0.33955228605956556 0.3359085085038064 1.9524230353707779 0.15621122436504398 0.3875753466528367 1.8613443806607184e-07 6.730173267501181 -0.9122319083898202 DTVLGK(ub)WQYF ddPTM_RPMI8226_Bortezomib_8h_R1 1 DTVLGKWQYF 10 1 O14562;H3BRL3 O14562 UBFD1 Ubiquitin domain-containing protein UBFD1 1 315143000.0 122270000.0 120880000.0 71993000.0 True False 185492529.13434932 99308019.56024925 57763551.99434712 1.0 0.5353747669714612 0.3114063529346235 27.466785841374236 -10.644324931393765 0.1491814111125688 1.8843453808193429 3.946521734225905e-12 0.9996860850293784 0.0050811138024829065 2.5507141952467545 0.08055285669815695 1.0136257915290527 0.2052988175303728 2.2681672145928032e-11 10.644324931393765 -1.8843453808153963 DTVLGK(ub)WQYF ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DTVLGKWQYF 10 1 O14562;H3BRL3 O14562 UBFD1 Ubiquitin domain-containing protein UBFD1 1 97774000.0 23145000.0 40429000.0 34200000.0 True False 31702331.97010679 38642713.09917541 26122664.37110952 1.0 1.2189233629757248 0.8239981965913886 24.918085630695103 -6.756245208075067 1.6267525231134838 1.1277547594832835 0.8228238484695605 0.6754112325111634 0.09203631581684253 0.2892629846705949 1.507808866847874 0.04466021839977819 0.10772089154860846 1.752890518564742e-07 6.756245208075067 -0.30493091101372305 DTVLGK(ub)WQYF ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DTVLGKWQYF 10 1 O14562;H3BRL3 O14562 UBFD1 Ubiquitin domain-containing protein UBFD1 1 202511000.0 73781000.0 97299000.0 31431000.0 True False 61352170.55249915 96774830.97466071 38003076.779475875 1.0 1.5773660508367886 0.6194251391147861 25.870611049500415 -6.743491059519629 1.6738469765840687 1.342122261919856 0.6184132002974716 0.6206028467045748 0.24257359932191652 0.3115038598316668 1.7149315080520222 0.1145848763503721 0.2801181024074956 1.8051318975857155e-07 6.743491059519629 -0.7237090616223845 DTVLGK(ub)WQYF ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DTVLGKWQYF 10 1 O14562;H3BRL3 O14562 UBFD1 Ubiquitin domain-containing protein UBFD1 1 308096000.0 122270000.0 138350000.0 47476000.0 True False 158280925.3020251 130650700.88057578 38835855.14489702 1.0 0.8254355389398534 0.24536029891657538 27.237912163466685 -6.949132354694558 0.5682911675596166 1.0072825416535631 0.035393204677221415 0.9991314093149636 0.009506627680043156 0.08383606951577124 0.03741905596227427 0.010091430468457369 0.04831158040958484 1.1242622938841295e-07 6.949132354694558 -0.9718893369763417 down DTVLK(ub)LLLNGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTVLKLLLNGAR 12 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659;A0A087X146 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 4890100.0 1806200.0 1656900.0 1427000.0 True False 1748863.1696638921 2318508.8106193533 1053225.890917633 1.0 1.3257233903924797 0.6022345882668733 20.73798598713173 -6.78430843842576 1.519024388865207 1.183400614550348 0.5957035599827072 0.782359828235007 0.138020066359785 0.24393608181803744 1.1119668241299596 0.07154448802784845 0.16822167813993763 1.6432042956151744e-07 6.78430843842576 -0.5876970545676408 DTVLK(ub)LLLNGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DTVLKLLLNGAR 12 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659;A0A087X146 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 8347000.0 2275200.0 3155200.0 2916600.0 True False 2945291.2508969293 2979610.34635629 2385808.7268431764 1.0 1.0116521907464702 0.810041698292699 21.489978874160386 -6.89319138638989 1.0032885020651356 1.0100185845862797 0.7915754189183011 0.9828643927103616 0.012097555506318112 0.11659286141112091 0.2070165336945804 0.009146648029632677 0.023081508721693376 1.2788176262035332e-07 6.89319138638989 -0.2184431656679786 DTYEEVK(ub)QAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DTYEEVKQAGR 11 1 I3L1R7;Q99447;I3L1L9;Q99447-4;Q99447-3;I3L2Q1;Q99447-2;I3L1C4 I3L1R7 PCYT2 Ethanolamine-phosphate cytidylyltransferase 1 5807200.0 816920.0 757880.0 4232400.0 True False 790987.3217593996 1060505.4362919878 3123807.4707216425 1.0 1.3407363267632366 3.949250999084703 19.593295045264554 -6.930924494905549 0.7391637170292031 0.961662304979645 4.49759591099573 0.9967168615438615 0.07548200748295306 0.09216056806907294 0.0753490987722869 0.06914986602056898 0.2348370529516522 1.1723991775229027e-07 6.930924494905549 3.535933606016085 up DTYEEVK(ub)QAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DTYEEVKQAGR 11 1 I3L1R7;Q99447;I3L1L9;Q99447-4;Q99447-3;I3L2Q1;Q99447-2;I3L1C4 I3L1R7 PCYT2 Ethanolamine-phosphate cytidylyltransferase 1 25933500.0 3223500.0 5388000.0 17322000.0 True False 4890285.169416663 4426469.303363859 13898299.107497694 1.0 0.9051556606650547 2.8420222187483497 22.221487165484824 -6.89538907888166 0.9899708475148977 0.9089716193006862 3.027310351671881 0.9841289235472909 0.11231584425409286 0.11487890389347706 0.19718368835478364 0.08577549162143418 0.21843046764753024 1.2723626767783823e-07 6.89538907888166 2.118338732371195 up DTYEEVK(ub)QAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DTYEEVKQAGR 11 1 I3L1R7;Q99447;I3L1L9;Q99447-4;Q99447-3;I3L2Q1;Q99447-2;I3L1C4 I3L1R7 PCYT2 Ethanolamine-phosphate cytidylyltransferase 1 5400420.0 816920.0 1218900.0 3364600.0 True False 679305.175692219 1212333.5437672925 4068122.3038472994 1.0 1.784667020285709 5.98865200710688 19.37370032069883 -6.938276324697401 0.6754075414169892 0.9511090663326569 7.067072934344091 0.9979293254730817 0.09966784488399665 0.08856182731844064 0.05825678161057554 0.09579618412703116 0.36466182598475916 1.15271959377466e-07 6.938276324697401 6.115963868011434 DTYEEVK(ub)QAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DTYEEVKQAGR 11 1 I3L1R7;Q99447;I3L1L9;Q99447-4;Q99447-3;I3L2Q1;Q99447-2;I3L1C4 I3L1R7 PCYT2 Ethanolamine-phosphate cytidylyltransferase 1 23856500.0 3223500.0 3357000.0 17276000.0 True False 4172884.2946845363 3170179.9989598366 14131945.266729338 1.0 0.759709537836466 3.3866132556636566 21.992613487577273 -6.884540442630921 1.0541167309751494 0.8398340962715433 3.5898081263633173 0.9771685029783296 0.17916977702069903 0.12368570440955551 0.2486079007787868 0.13034745229042935 0.31919308984223727 1.3045464802244662e-07 6.884540442630921 2.749974030091774 up DVACGANHTLVLDSQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVACGANHTLVLDSQK 16 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 31632310.0 3279700.0 18088300.0 10264310.0 False True 4299718.460659974 15389596.147641158 9202257.663413955 1.0 3.579210194445841 2.1402000497496476 22.035810766648847 -9.862821022939288 6.204389379621402 0.9999998364930869 2.8597051220983327 0.6901043081059415 0.5874734315344794 1.3294843281708457e-06 2.4453894998883044e-07 0.5688187550203114 0.189606234722388 1.3714468365564044e-10 9.862821022939288 1.8597052856052458 DVACGANHTLVLDSQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVACGANHTLVLDSQK 16 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 33407790.0 3279700.0 15258490.0 14869600.0 False True 4492293.7205599155 14584319.458721122 11357706.729024863 1.0 3.2465195657115995 2.528264498165816 22.09902082817174 -10.066168305697657 5.452118389115369 0.9999847067016328 2.887392031939899 0.9020254621609365 0.2932264034467585 5.450983682873692e-05 9.33659200216866e-06 0.283917530801812 0.09463841476752635 8.586806854571702e-11 10.066168305697657 1.8874073252382662 DVACGANHTLVLDSQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVACGANHTLVLDSQKR 17 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 12587400.0 3921400.0 5209600.0 3456400.0 True False 5140993.374891616 4432347.986861753 3098764.884129963 1.0 0.8621578873276018 0.6027560547469665 22.293615722237707 -6.961218002690187 0.4179170805811371 1.0117263995208083 0.4434356535003273 0.9998127305358616 0.002253658106679381 0.07926890809066561 0.01954492696236464 0.0033513966215663513 0.021605881288157543 1.0934073710752664e-07 6.961218002690187 -0.568290746020481 DVACGANHTLVLDSQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVACGANHTLVLDSQKR 17 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 7460700.0 3041100.0 1834300.0 2585300.0 True False 2944561.9451139765 2566745.555748132 1908132.3726624753 1.0 0.8716901201576793 0.6480190969759396 21.48962159332274 -6.962640629710603 0.396467892348138 1.0127848655979164 0.4988037015751581 0.9998559432433561 0.0017456490507176407 0.07877100991500706 0.017742344802822576 0.0028800301038653985 0.01876525812523248 1.0898315348492664e-07 6.962640629710603 -0.5139811640227583 DVACGANHTLVLDSQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVACGANHTLVLDSQKR 17 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 48949500.0 6845600.0 8650900.0 33453000.0 True False 10385275.680396691 7107079.3052098 26840999.887029234 1.0 0.6843419013541611 2.58452454350292 23.30803617769427 -6.864227826432571 1.1642851375762675 0.8264241474607478 2.684211938184484 0.9585698859668152 0.16922663934790008 0.14250439071182727 0.36471044893934307 0.11315944512334665 0.26551838856807425 1.367011517239435e-07 6.864227826432571 1.857787790723736 up DVACGANHTLVLDSQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVACGANHTLVLDSQKR 17 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 13107000.0 3921400.0 3953100.0 5232500.0 True False 5371247.551850371 3778438.9708464304 3996691.2667201934 1.0 0.7034564939284497 0.7440899396534705 22.3568257837606 -10.843618569613211 10.879056950044843 1.0054951968953134 0.7237732168346008 0.9840299829455541 0.01658853475289591 0.002213068397957492 3.181177453286102e-05 0.01607695345732696 0.005353926569662401 1.433446307956297e-11 10.843618569613211 -0.2817219800607126 DVACGANHTLVLDSQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVACGANHTLVLDSQKR 17 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 11467900.0 3041100.0 1326600.0 7100200.0 True False 2528809.393572941 1319453.3424905161 8584818.992384406 1.0 0.5217686021904038 3.394806668388305 21.270026868757018 -6.864134003476044 1.1647643850419933 0.7371199068417116 3.5452656064091728 0.9584648873776955 0.25615805525016233 0.1425984400408493 0.365306528727994 0.17122614308859235 0.4017163840389551 1.3673068719411985e-07 6.864134003476044 2.8081456995674614 up DVACGANHTLVLDSQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVACGANHTLVLDSQKR 17 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 39521500.0 6845600.0 6586900.0 26089000.0 True False 8861764.146949738 6220333.224649547 21341069.695745647 1.0 0.7019294489789164 2.408219101959664 23.07916249978672 -6.861817236733857 1.1764322976179584 0.8374177530424043 2.4937946628541345 0.9558165955735177 0.15641164819393652 0.14494639756916625 0.3801466696552001 0.10361414068626452 0.24239697683504324 1.3746203319963966e-07 6.861817236733857 1.6563769098117302 up DVAHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVAHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTR 40 1 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 538492000.0 153571000.0 143260000.0 241661000.0 False True 232978434.54396987 117694133.70451115 193896597.42622092 1.0 0.5051717938395659 0.8322512674005754 27.795621178285877 -10.123559000672488 7.385115906775796 1.0000001115803874 0.6687115306200706 0.577679501934353 0.13352963592710246 2.453033124159666e-07 2.9217591941133602e-08 0.12928955835321065 0.043096504680900635 7.52386508461528e-11 10.123559000672488 -0.33128858096031677 DVAHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVAHWLGCSATSTFNFHPNVRPVPLELHIQGFNISHTQTR 40 1 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 367628000.0 153571000.0 133800000.0 80257000.0 False True 198800686.83697823 126353912.38034734 65651049.506361164 1.0 0.6355808643858503 0.3302355266015592 27.566747500378327 -7.604241595122508 0.24096462620405507 1.1514635196294223 1.3638747299704853e-17 0.9998475278311749 0.0033806756079388244 0.13013045260738276 0.0275975395444867 0.034601723693052436 0.07334372962667357 2.4874731685951292e-08 7.604241595122508 -1.1514635196294223 down DVAIK(ub)EPLVDVVDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVAIKEPLVDVVDPK 15 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 38482800.0 9152200.0 11415900.0 17914700.0 True False 11998622.830030872 9712692.218829667 16061058.693936748 1.0 0.8094839179810003 1.3385751782894757 23.51636549085346 -6.809295615455277 1.4173534829657748 0.8960831608166505 1.3476955012229035 0.8580173422476388 0.08244570900733775 0.20776028462844362 0.822707140718584 0.04573877828697338 0.10584418808970794 1.551330691119068e-07 6.809295615455277 0.451612340406253 DVAIK(ub)EPLVDVVDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVAIKEPLVDVVDPK 15 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 53792000.0 14711800.0 15162700.0 23917500.0 True False 14244781.961832179 21217245.18243591 17652789.240380142 1.0 1.489474899600845 1.2392460121663822 23.76393020338886 -10.068899097122934 4.331766430065711 0.9999685741653629 1.3643604557524818 0.7386989455882217 0.10215551569094312 71450505.9008385 93360991.38173646 30513.23320484819 0.03738508728515023 8.532983441589469e-11 10.068899097122934 0.3643918815871189 DVAIK(ub)EPLVDVVDPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVAIKEPLVDVVDPK 15 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 139342000.0 33763000.0 36418000.0 69161000.0 True False 51220939.4059298 29918923.364867263 55491298.035656914 1.0 0.5841150848046254 1.0833713453766283 25.610230376808147 -6.685594140091939 1.8817774644048988 0.7382051933803159 1.0815748469574653 0.35004459076659233 0.17604922620785834 0.42619362285131457 2.922392860828332 0.07493539667186151 0.19624883891618594 2.0625565276039977e-07 6.685594140091939 0.34336965357714944 DVAIK(ub)EPLVDVVDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVAIKEPLVDVVDPK 15 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 41759700.0 9152200.0 7986300.0 24621200.0 True False 12536015.668905232 7633438.858837568 18806179.64953103 1.0 0.6089206539340737 1.5001719961294024 23.57957555237635 -6.7874435757469564 1.5066497751015888 0.7806976451734499 1.508979701975466 0.7929023585090685 0.16599459005626474 0.23918185416703364 1.072649040857535 0.08673583150527744 0.2034441444077483 1.6313848476611546e-07 6.7874435757469564 0.7282820568020162 DVAIK(ub)EPLVDVVDPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVAIKEPLVDVVDPK 15 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 54042000.0 14711800.0 16853800.0 22476400.0 True False 12233513.543246334 16763005.234182637 27176111.320868257 1.0 1.3702527221573941 2.2214477651738225 23.544335478823136 -6.957232456687771 0.47283116247304163 0.97812513627695 2.648636734554319 0.9996533667544539 0.009520854374351123 0.08070503913902796 0.02490009318156025 0.011832677170494568 0.07024055142914656 1.103487818508735e-07 6.957232456687771 1.6705115982773688 up DVAIK(ub)EPLVDVVDPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVAIKEPLVDVVDPK 15 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 143390000.0 33763000.0 34193000.0 75434000.0 True False 43706869.0682283 32290129.49193732 61705786.018202126 1.0 0.7387884371568928 1.4118097986354674 25.381356698900596 -6.801472877897501 1.4500223194506483 0.8561471850089973 1.42142793254173 0.8364019256997924 0.11205639061058383 0.2186608158272372 0.9075181127909545 0.06079262742354358 0.14124800658135767 1.579527247633883e-07 6.801472877897501 0.5652807475327327 DVAWAPSIGLPTSTIASCSQDGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVAWAPSIGLPTSTIASCSQDGR 23 0 P55735;P55735-2;P55735-4;P55735-3;A8MXL6 P55735 SEC13 Protein SEC13 homolog 0 5114650.0 730450.0 2627700.0 1756500.0 False True 957627.023687863 2235657.402694375 1574754.2295377492 1.0 2.3345805281107896 1.6444337832837075 19.869104339323037 -10.239813921123735 5.679847423917721 0.9999523946120707 1.9895071556972608 0.7326848898499749 0.2817512287449329 0.000169864853195135 2.2735161189543892e-05 0.2728174734024636 0.09093481805853894 5.7568654456778046e-11 10.239813921123735 0.98955476108519 DVAWAPSIGLPTSTIASCSQDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVAWAPSIGLPTSTIASCSQDGR 23 0 P55735;P55735-2;P55735-4;P55735-3;A8MXL6 P55735 SEC13 Protein SEC13 homolog 0 5917350.0 730450.0 2767000.0 2419900.0 False True 1000517.1046690234 2644744.790754614 1848369.459404909 1.0 2.6433778877068876 1.8474141529208137 19.93231440084593 -10.313155408391363 5.600127210790566 0.9998226258258072 2.2453960203138665 0.765485439253694 0.3249508339977029 0.0007197260341198033 8.827233327268083e-05 0.31467543482819327 0.10487743070076792 4.8623318036710436e-11 10.313155408391363 1.2455733944880594 DVCISLEIDDLKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVCISLEIDDLKK 13 1 O75822-3;O75822;H0YGJ7;H0YLP3 O75822-3 EIF3J Eukaryotic translation initiation factor 3 subunit J 0 7566300.0 3641100.0 3925200.0 0.0 False True 4713475.7268111855 3706759.1694718893 0.0 1.0 0.7864173667824589 0.0 22.16835986792227 -7.272315622896763 0.8371552722932155 0.9890425241853259 2.0070084494585035e-17 0.988577572171675 0.0459561591542024 0.1008949289179546 0.1377033768125472 0.0390467038217008 0.06889920985035937 5.3417600664391244e-08 7.272315622896763 -0.9890425241853259 down DVDETGITVASLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVDETGITVASLER 14 0 Q8WU90;H7C466 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 0 5090300.0 1145500.0 1626100.0 2318700.0 False True 1501761.5930377797 1383492.2184881554 2078783.1665409517 1.0 0.9212462383523954 1.3842298112951248 20.518224370297634 -6.863102592965862 1.1698755662038538 0.9568619647249897 1.4080244334352177 0.9573061410923879 0.04179232681810915 0.14364459345076253 0.37180572039485377 0.027824322132576795 0.06519803446104352 1.370557962337163e-07 6.863102592965862 0.4511624687102279 DVDFELIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVDFELIK 8 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 13122100.0 2479100.0 5377500.0 5265500.0 False True 3250124.107638547 4575197.9613308245 4720676.570242534 1.0 1.4076994630999 1.4524604027113448 21.632063378559444 -11.958786928011921 0.3529214536780945 1.4934745959644915e-19 1.4589868829346075 0.999612000685091 0.004009727822249036 5.249728420444033 0.18479451420349444 3.887443877672504 0.013214666082843452 1.0995451619923154e-12 11.958786928011921 1.4589868829346075 DVDFELIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVDFELIK 8 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 12544700.0 5092700.0 1924500.0 5527500.0 False True 4931035.026103046 2692962.88613492 4079681.9285544576 1.0 0.5461252803679931 0.8273479922487176 22.233459069943716 -10.34789290385304 6.179308497517558 1.0000292643367983 0.6867366363083557 0.6232760270578004 0.11480869136491767 4.629078441845187e-05 4.88532996244132e-06 0.11117340132534519 0.0370543458046827 4.4885606329034046e-11 10.34789290385304 -0.3132926280284426 DVDFELIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVDFELIK 8 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 14649400.0 2479100.0 5421400.0 6748900.0 False True 3395690.2651584246 5181864.621827635 5154948.817958508 1.0 1.5260121557599946 1.5180856955214688 21.695273440082335 -10.026361511629869 4.723718097656964 0.9999870045195989 1.5220489256578036 0.9998271283664251 0.003235963899955361 2236087.577006318 0.025001349481437136 319.52378881395254 0.001107756505798461 9.411058832200296e-11 10.026361511629869 0.5220619211382047 DVDFELIK(ub)VEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVDFELIKVEGK 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 52414000.0 13930000.0 18456000.0 20028000.0 True False 21132828.419411846 15162382.602613814 16069457.021415778 1.0 0.7174800410855654 0.7604025690501022 24.3329825348245 -10.112707849097438 4.9332080189232475 1.0000109532095192 0.7389413050667569 0.9801281440620421 0.01752304866793899 18804965721.58498 3382409392.439758 2415384.0981019256 0.005998958574654681 7.714222320782572e-11 10.112707849097438 -0.26106964814276223 DVDIIDHHDNTYTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVDIIDHHDNTYTVK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 7644380.0 2293800.0 772280.0 4578300.0 False True 2220984.5745626385 1080655.4313869956 3379105.883944072 1.0 0.48656593285876415 1.521445003556359 21.082767942272433 -6.77180817228565 1.5674773990327298 0.7061823520146738 1.527673135931602 0.7374179277821558 0.21649648595179266 0.2635320403267694 1.278089232757783 0.10884969699562566 0.2586858577191786 1.6911877637121656e-07 6.77180817228565 0.8214907839169282 DVDYVCISDNYWLGKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVDYVCISDNYWLGKK 16 1 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;J3QRH4;J3KRJ8 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 1 17356600.0 3701400.0 3396200.0 10259000.0 True False 4791535.265501886 3207198.484500266 8391967.266229229 1.0 0.6693467347702658 1.7514151104448188 22.19205655619265 -6.824692493582051 1.3513613075215156 0.8225689373010969 1.7775172748762034 0.8948453056994564 0.14681520781260554 0.1874609859376037 0.6713391073646737 0.08534200735812694 0.1965061003799691 1.4972954554115047e-07 6.824692493582051 0.9549483375751064 DVEGSTSPQIGDKVEFSISDK(ub)QRPGQQVATCVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVEGSTSPQIGDKVEFSISDKQRPGQQVATCVR 33 3 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 26209000.0 7133500.0 9651400.0 9424100.0 True False 9234456.372307166 9114291.105737545 7709010.499431798 1.0 0.9869872939212773 0.8348093475810915 23.13859560231733 -6.9237686270450185 0.7962723319532539 1.0029239109332055 0.8080076218317144 0.9951654380351782 0.005214328923924338 0.09600482519711451 0.09449205271415954 0.004584800131411075 0.014270194902168036 1.1918768183402651e-07 6.9237686270450185 -0.19491628910149117 DVEK(ub)AFMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVEKAFMK 8 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 12847700.0 1713000.0 1857800.0 9276900.0 True False 2217512.2682781457 1754411.7968625498 7588599.389032256 1.0 0.7911621603901275 3.422122843507266 21.08051065551233 -6.88769883982119 1.035920632035083 0.8507382356004762 3.6384476501817176 0.9793832787634561 0.17145094768512942 0.1210291943771201 0.23292373022922716 0.12647391748049905 0.3127932115885477 1.2950936088348878e-07 6.88769883982119 2.7877094145812413 up DVETTSSVSVK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVETTSSVSVKR 12 1 Q96RL1;Q96RL1-2;D6RC40;D6RCQ3;Q96RL1-5;D6RDZ5 Q96RL1 UIMC1 BRCA1-A complex subunit RAP80 1 10460100.0 3969900.0 3072000.0 3418200.0 True False 5204577.344566283 2613669.5745622115 3064517.4536896828 1.0 0.5021867101832874 0.5888119727703001 22.311349578640126 -10.815397755510777 7.284783369935126 1.0205469401589826 0.5454993414767938 0.9734779262818175 0.03536461536213114 0.011025702308012022 0.0002793997948880255 0.03199088393101445 0.011413880528547072 1.52968583282102e-11 10.815397755510777 -0.4750475986821888 DVETTSSVSVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVETTSSVSVKR 12 1 Q96RL1;Q96RL1-2;D6RC40;D6RCQ3;Q96RL1-5;D6RDZ5 Q96RL1 UIMC1 BRCA1-A complex subunit RAP80 1 23474200.0 7566300.0 5986800.0 9921100.0 True False 7326111.94808322 8377360.460749563 7322466.283379753 1.0 1.1434933727625316 0.9995023738745323 22.80461631592218 -6.646999836478551 2.019502218424891 1.093335119067329 1.0001098614582211 0.1818649528056765 0.06129039750160331 0.5159298372740561 4.029776562236884 0.02464437644927356 0.06786827476171338 2.2542400609233582e-07 6.646999836478551 -0.09322525760910794 DVETTSSVSVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVETTSSVSVKR 12 1 Q96RL1;Q96RL1-2;D6RC40;D6RCQ3;Q96RL1-5;D6RDZ5 Q96RL1 UIMC1 BRCA1-A complex subunit RAP80 1 21900900.0 4245700.0 5002200.0 12653000.0 True False 6441037.302246729 4109518.3276330126 10152129.003993101 1.0 0.6380211967099697 1.5761636717197538 22.618861616405894 -6.802099376795757 1.447336913001112 0.8008065030261308 1.5897926012832084 0.838217353568339 0.15538161113238386 0.21778117654783014 0.9004306121166706 0.08444866815282784 0.19614975442442656 1.5772503164208904e-07 6.802099376795757 0.7889860982570777 DVETTSSVSVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVETTSSVSVKR 12 1 Q96RL1;Q96RL1-2;D6RC40;D6RCQ3;Q96RL1-5;D6RDZ5 Q96RL1 UIMC1 BRCA1-A complex subunit RAP80 1 10090000.0 3969900.0 3157200.0 2962900.0 True False 5437679.312513588 3017704.4645357686 2263124.0428409446 1.0 0.5549618304248294 0.41619299572022883 22.374559640163017 -13.999999999999998 0.16316029715491928 3.2070235933247733 0.2844238251670417 0.999528414846513 0.005407949359497272 12.032234035361283 0.1277477651586876 8.402577762755357 0.12059019406023254 1.0000000000000041e-14 13.999999999999998 -2.9225997681577316 DVETTSSVSVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVETTSSVSVKR 12 1 Q96RL1;Q96RL1-2;D6RC40;D6RCQ3;Q96RL1-5;D6RDZ5 Q96RL1 UIMC1 BRCA1-A complex subunit RAP80 1 26077600.0 7566300.0 11793000.0 6718300.0 True False 6291713.693923562 11729468.768272785 8123065.468090493 1.0 1.8642724921829996 1.2910736030368994 22.585021591356455 -10.605344879826852 7.983383701922249 0.999591681694014 1.5776730476099494 0.5752325741637339 0.23400746658968072 0.001701766022385259 8.412607299011894e-05 0.22672410811557214 0.07552558508250182 2.4811619944297823e-11 10.605344879826852 0.5780813659159354 DVETTSSVSVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVETTSSVSVKR 12 1 Q96RL1;Q96RL1-2;D6RC40;D6RCQ3;Q96RL1-5;D6RDZ5 Q96RL1 UIMC1 BRCA1-A complex subunit RAP80 1 22414400.0 4245700.0 9648200.0 8520500.0 True False 5496142.345258923 9111269.188550577 6969856.427712856 1.0 1.6577571351313583 1.2681360834340811 22.389987938498344 -10.121646167114022 4.298655425899582 0.9999303924776457 1.4629466090582992 0.6530688746387983 0.15906212849416002 22887151.73925621 17963430.599520262 14757.407734005365 0.054451196259393764 7.557076748819636e-11 10.121646167114022 0.4630162165806535 DVFEAFYKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVFEAFYKK 9 1 A0A0A0MR50;Q13619-2;Q13619;A0A669KAX4;K4DI93;Q13620-3;Q13620-1;Q13620 A0A0A0MR50;A0A669KAX4 CUL4A;CUL4B Cullin-4A;Cullin-4B 1 16183500.0 3835100.0 5775300.0 6573100.0 True False 5253040.109680561 5520128.14963683 5020669.157243864 1.0 1.0508444699411423 0.9557644815982895 22.32472116958233 -6.7613936887229995 1.6068727751203864 1.0294805318798093 0.9553883044966136 0.6968244857320645 0.021389960537043087 0.28055148563318155 1.427959906507355 0.010500673425784516 0.025203706868951018 1.7322330134931763e-07 6.7613936887229995 -0.07409222738319565 DVFEAK(ub)AR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVFEAKAR 8 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 13885800.0 4122900.0 5527000.0 4235900.0 True False 5405161.8262203885 4702393.144077261 3797609.701621944 1.0 0.8699819349100699 0.7025894549909265 22.365906381065916 -6.967671964324428 0.30877534743049423 1.026164000906389 0.5410959057456921 0.9999581034915899 0.0007879489078596562 0.07706561674727672 0.011720393497648914 0.002663271885457888 0.014879002397071938 1.077278607312189e-07 6.967671964324428 -0.48506809516069693 DVFEAK(ub)AR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVFEAKAR 8 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 27758700.0 6380400.0 8018300.0 13360000.0 True False 6177857.694454383 11220049.004882112 9860615.208591139 1.0 1.8161714885329754 1.596122101912872 22.558675208520626 -10.026706552985688 4.498895614745977 0.9999722186644286 1.7061467952806453 0.9321139390341535 0.08983478613063424 11843110.84067365 6598697.998028437 3185.3046902482815 0.030752836239072996 9.40358483691612e-11 10.026706552985688 0.7061745766162166 DVFEAK(ub)AR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVFEAKAR 8 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 13068500.0 4122900.0 4222400.0 4723200.0 True False 5647247.547183119 4035840.4063904136 3607677.4373574425 1.0 0.7146561882883131 0.638838196345222 22.429116442588807 -13.999999999999998 0.18603497426181692 2.5092502570451063 0.5822210747042948 0.999492085170711 0.0035043731162764363 12.28881653460852 0.13676964558997343 6.7147355455290825 0.05383342919939926 1.0000000000000041e-14 13.999999999999998 -1.9270291823408114 DVFEAK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVFEAKAR 8 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 23928400.0 6380400.0 10190000.0 7358000.0 True False 5305585.299645786 10135104.447443374 8896523.780451877 1.0 1.9102707571434234 1.6768223066823242 22.339080483954902 -10.392895546083402 6.623961938941294 0.9999244671968779 1.7935465319128738 0.9390482251335076 0.09530493081218165 0.00010631913516019775 9.7442811438745e-06 0.09228726095302177 0.030759534153919115 4.0467320957879583e-11 10.392895546083402 0.793622064715996 DVFEAK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVFEAKAR 8 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 33429000.0 8564100.0 6167900.0 18697000.0 True False 11086396.27364909 5824650.942980147 15294337.847420583 1.0 0.525387222250442 1.3795590081669025 23.402287145757537 -6.755878320650073 1.6278199252634615 0.7229099736917863 1.3820763324669227 0.6739669807515366 0.19952388954810124 0.2899056416545695 1.5129965534636824 0.09675228987035693 0.2334823872668176 1.7543719677650894e-07 6.755878320650073 0.6591663587751364 DVFHMVVEVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVFHMVVEVPR 11 0 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 23066000.0 7474700.0 8890200.0 6701100.0 False True 9799404.085097756 7563816.813728175 6007734.453490126 1.0 0.7718649775072236 0.6130714073344792 23.22426258899955 -7.564676911681873 0.09418256122512084 1.4746869621521814 3.556090941282558e-07 0.9999973865106706 0.00025666580419472204 0.13660536858902522 0.009023087773898588 0.05791379984262027 0.07880219386174277 2.7247275836016613e-08 7.564676911681873 -1.4746866065430873 DVFHMVVEVPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVFHMVVEVPR 11 0 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 19230700.0 7230800.0 6804600.0 5195300.0 False True 7001262.211939802 9521712.265520213 3834495.0743408334 1.0 1.3599993797235717 0.5476862540302473 22.739183608917394 -6.786235570919448 1.5113953800233595 1.2021912555543066 0.5399264818495798 0.7888875662141129 0.1526994799967304 0.24100536345707618 1.087632754566338 0.07954345862184341 0.18674975198614316 1.6359289167434154e-07 6.786235570919448 -0.6622647737047268 DVFHMVVEVPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVFHMVVEVPR 11 0 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 27721400.0 4261500.0 19230900.0 4229000.0 False True 6465007.057381448 15798995.643292489 3393136.296363453 1.0 2.4437708270177247 0.5248464953320238 22.62422051424658 -6.705331156198689 1.81142295066431 1.891731189934888 0.5298254844483911 0.44325833287988925 0.608849840102005 0.3844481034393874 2.4558928948213845 0.2677575196632204 0.684217309376598 1.9709193068149104e-07 6.705331156198689 -1.361905705486497 DVFHMVVEVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVFHMVVEVPR 11 0 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 19287600.0 7474700.0 5832900.0 5980000.0 False True 10238298.586172272 5575183.191179101 4567647.161965931 1.0 0.544541961172033 0.44613341987651567 23.287472650522442 -13.999999999999963 0.21532778162273394 3.6934788782152936 0.39107855780249695 0.9994936623413716 0.0054290084189620854 12.876745864955568 0.14704000201818174 14.71220240745834 0.056190523542497525 1.0000000000000858e-14 13.999999999999963 -3.3024003204127967 DVFHMVVEVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVFHMVVEVPR 11 0 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 15982400.0 7230800.0 2380300.0 6371300.0 False True 6012730.578753483 2367476.851447444 7703509.372437219 1.0 0.39374404364851034 1.2811998261918227 22.51958888435167 -6.722780204473281 1.7491037023002687 0.6322677619461521 1.2800582781799636 0.5257092690705548 0.2550312363002642 0.3499377311842387 2.093684763689021 0.11570151547674133 0.2895313961841184 1.893301572171439e-07 6.722780204473281 0.6477905162338116 DVFHMVVEVPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVFHMVVEVPR 11 0 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 14434800.0 4261500.0 5982900.0 4190400.0 False True 5516595.756723481 5649946.355608214 3427790.1971349013 1.0 1.0241726247064973 0.6213596841779101 22.39534683633903 -6.892635717892362 1.006633621792391 1.02029588427406 0.5848670502641059 0.9825332827611992 0.024377817497515664 0.11703171083945713 0.2095516428847157 0.018385019911641095 0.04629239818563869 1.2804548872989361e-07 6.892635717892362 -0.435428834009954 DVFHTTVNFINQNLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVFHTTVNFINQNLR 15 0 P55957-4;P55957;P55957-2 P55957-4 BID BH3-interacting domain death agonist;BH3-interacting domain death agonist p15;BH3-interacting domain death agonist p13;BH3-interacting domain death agonist p11 0 5530600.0 1952100.0 2212500.0 1366000.0 False True 2559222.0041632904 1882403.6242574519 1224659.423597248 1.0 0.7355374489572205 0.4785280142187731 21.287273871220183 -6.971475619388561 0.22011964014068053 1.1183424853104167 0.0884648490839558 0.9999917146011364 0.0006127842266571324 0.07582682684237008 0.007292997725233447 0.007112447773687001 0.02604259293097101 1.0678847402317605e-07 6.971475619388561 -1.0298776362264608 down DVFHTTVNFINQNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVFHTTVNFINQNLR 15 0 P55957-4;P55957;P55957-2 P55957-4 BID BH3-interacting domain death agonist;BH3-interacting domain death agonist p15;BH3-interacting domain death agonist p13;BH3-interacting domain death agonist p11 0 26001700.0 9778100.0 4403600.0 11820000.0 False True 9467699.567761334 6161980.444470623 8723987.407600852 1.0 0.6508424142917372 0.921447427135002 23.174582496036997 -9.817404975464099 5.894632299047681 1.0000000228642387 0.7861449207128934 0.4543670267184162 0.11047403388590547 3.320187875987094e-08 6.760041224594081e-09 0.10696603451379075 0.035655341118791636 1.5226322515390243e-10 9.817404975464099 -0.2138551021513453 DVFHTTVNFINQNLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVFHTTVNFINQNLR 15 0 P55957-4;P55957;P55957-2 P55957-4 BID BH3-interacting domain death agonist;BH3-interacting domain death agonist p15;BH3-interacting domain death agonist p13;BH3-interacting domain death agonist p11 0 15630200.0 4778400.0 6700700.0 4151100.0 False True 7249182.147833288 5504907.732191944 3330633.2655082364 1.0 0.759383282131669 0.459449521006136 22.789386808890182 -6.968150931618533 0.29908055178696796 1.0525902344690226 0.15685676428960027 0.999964148944868 0.001323967526783916 0.07690744924035127 0.011166688612456612 0.004998827251071119 0.026926025716469723 1.0760911715576144e-07 6.968150931618533 -0.8957334701794223 down DVFHTTVNFINQNLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVFHTTVNFINQNLR 15 0 P55957-4;P55957;P55957-2 P55957-4 BID BH3-interacting domain death agonist;BH3-interacting domain death agonist p15;BH3-interacting domain death agonist p13;BH3-interacting domain death agonist p11 0 11655900.0 1952100.0 1155600.0 8548200.0 False True 2673844.1235189247 1104541.7709418254 6529291.215705222 1.0 0.41309130970888014 2.441911687474257 21.350483932743074 -6.829332368127041 1.3310047876265916 0.6862561649631609 2.4957204740389445 0.9045120099161121 0.26340952676169843 0.1816367804116909 0.6295774822589434 0.15540090332694828 0.35761034686077386 1.481383939355961e-07 6.829332368127041 1.8094643090757836 up DVFHTTVNFINQNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVFHTTVNFINQNLR 15 0 P55957-4;P55957;P55957-2 P55957-4 BID BH3-interacting domain death agonist;BH3-interacting domain death agonist p15;BH3-interacting domain death agonist p13;BH3-interacting domain death agonist p11 0 20189000.0 9778100.0 4370100.0 6040800.0 False True 8130923.393277297 4346557.4039030615 7303903.350496564 1.0 0.5345711912003531 0.8982870698960811 22.954987771471274 -9.842096650772763 6.377968798799061 1.0000000116839634 0.7164291305481599 0.44765752220434185 0.1484863856922991 2.4814735487153707e-08 4.366700320458683e-09 0.14377133115818513 0.04792377491037009 1.4384784141100797e-10 9.842096650772763 -0.2835708811358034 DVFHTTVNFINQNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVFHTTVNFINQNLR 15 0 P55957-4;P55957;P55957-2 P55957-4 BID BH3-interacting domain death agonist;BH3-interacting domain death agonist p15;BH3-interacting domain death agonist p13;BH3-interacting domain death agonist p11 0 12746200.0 4778400.0 4242000.0 3725800.0 False True 6185732.996345775 4005928.970982307 3047742.6299363356 1.0 0.6476078054692648 0.49270517038753386 22.56051313098263 -13.999999999999998 0.11161420962144067 2.6957778179935525 0.2150333544873498 0.9997348722644399 0.003456316746366379 12.003398352516017 0.10163937699544795 4.57364259644582 0.2465408536602383 1.0000000000000041e-14 13.999999999999998 -2.480744463506203 DVFISAAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVFISAAER 9 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 23869900.0 4758700.0 8124200.0 10987000.0 False True 6238701.783316356 6912101.027883567 9850170.634745935 1.0 1.1079390020481548 1.5788814687516288 22.57281441802262 -6.942884674079608 0.63216336981434 0.9948617835489388 1.7174339412388517 0.9985177881253058 0.009676423236783402 0.08647503992537148 0.048800462594898064 0.009639516829397078 0.040046518723822346 1.1405526185274005e-07 6.942884674079608 0.7225721576899129 DVFISAAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVFISAAER 9 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 20247800.0 6841900.0 2294900.0 11111000.0 False True 6624707.629566719 3211265.5377454045 8200695.777144933 1.0 0.48474071873198027 1.2378955020662987 22.659425354350496 -6.722565927013505 1.7503151622646418 0.6873837231383724 1.236876698427389 0.5245264462532497 0.21675695396583086 0.350339122419777 2.0989686616484353 0.09828307558997959 0.24596410462067456 1.8942359426675418e-07 6.722565927013505 0.5494929752890165 DVFISAAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVFISAAER 9 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 24682300.0 3159700.0 18602000.0 2920600.0 False True 4793495.90501189 15282327.761910634 2343342.1298555476 1.0 3.188138274183573 0.48885869025264866 22.192646769179376 -6.691025497879135 1.8625347734516606 2.3704559314604667 0.49797883574578444 0.3754178215717313 0.9252281428052087 0.41441619981975036 2.788034722626588 0.3972615646358173 1.0332519174346948 2.036922484364906e-07 6.691025497879135 -1.8724770957146823 DVFISAAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVFISAAER 9 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 16596000.0 4758700.0 6825300.0 5012000.0 False True 6518119.989032077 6523735.677751162 3828268.8253801474 1.0 1.00086155037473 0.5873271482915176 22.63602447954551 -6.906428982965657 0.9197198865803591 1.0142942805798518 0.5377756812994497 0.9895025017310889 0.019952455334498815 0.10682678034837076 0.15193094849357136 0.0160522325630748 0.04328760440319541 1.2404264464973258e-07 6.906428982965657 -0.4765185992804021 DVFISAAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVFISAAER 9 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 11859700.0 6841900.0 2944600.0 2073200.0 False True 5689342.997562308 2928736.8553426648 2506696.5346062584 1.0 0.5147759339870227 0.4405950802544852 22.439830629784772 -13.999999999999998 0.2644112796519732 4.63527936927697 0.4146065770509274 0.999571459590256 0.005135489356676768 14.616584987991658 0.16273810104831865 28.466719925303696 0.03169428083848999 1.0000000000000041e-14 13.999999999999998 -4.2206727922260425 DVFISAAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVFISAAER 9 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 12114000.0 3159700.0 6406000.0 2548300.0 False True 4090293.936998519 6049500.468673435 2084535.5477660543 1.0 1.4789891782478088 0.5096297674136588 21.963773091271825 -6.772354966659803 1.5655572757579332 1.2739064417978292 0.5036998180049057 0.7394599669008897 0.20200234681898033 0.26263047707653114 1.27069691700822 0.10168689929617566 0.2415262259467448 1.689059829556767e-07 6.772354966659803 -0.7702066237929235 DVFRDPALK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVFRDPALKR 10 2 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 14068100.0 1907300.0 2576500.0 9584300.0 True False 2500488.770319475 2192096.2431183374 8592608.575097436 1.0 0.8766671017035859 3.436371591462737 21.25377869524917 -6.895583037881083 0.988786693570978 0.8802997456146877 3.6821877597780692 0.9842371932252667 0.14798107913706615 0.11472937372122599 0.19632974184264732 0.11311369261718199 0.28828854527883124 1.271794557444744e-07 6.895583037881083 2.8018880141633815 up DVFRDPALK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVFRDPALKR 10 2 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 20676500.0 3553200.0 3896300.0 13227000.0 True False 3440405.610923347 5452112.908936075 9762451.898505611 1.0 1.5847296875768144 2.8375874831472365 21.71414723261534 -6.958675389591186 0.4537158474191587 0.9610976171624749 3.5111960227875314 0.9997178746974215 0.012875298904287078 0.0801777217769251 0.02290553127440864 0.016841176320668956 0.10357767669323178 1.0998275908192174e-07 6.958675389591186 2.5500984056250564 DVFRDPALK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVFRDPALKR 10 2 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 36968500.0 7368500.0 13455000.0 16145000.0 True False 11178553.209507255 11053850.125605166 12953933.673395107 1.0 0.9888444343767108 1.1588202364486584 23.41423014286341 -6.891216781215137 1.0151308507903105 0.9911316619376652 1.1737945196011101 0.9816666476921159 0.010511381861517217 0.11816242861777812 0.21611272548436655 0.007876722218542225 0.01972529416223586 1.2846452599534453e-07 6.891216781215137 0.18266285766344492 DVFRDPALK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVFRDPALKR 10 2 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 23630800.0 1907300.0 1770500.0 19953000.0 True False 2612480.352844449 1692273.4557394446 15240512.344934173 1.0 0.6477650459253826 5.833732808111042 21.316988756772062 -6.890639936075304 1.0186253594049661 0.7256101729894716 6.285346549079675 0.9813034502853871 0.3235212421085028 0.11862405768178409 0.21884476729744826 0.24180104735638405 0.6041985669337894 1.2863527044686995e-07 6.890639936075304 5.559736376090203 up DVFRDPALK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVFRDPALKR 10 2 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 27319900.0 3553200.0 7652700.0 16114000.0 True False 2954643.233449535 7611473.386157984 19483362.897282112 1.0 2.576105737568734 6.594150751167124 21.494552508049615 -6.955041587753237 0.500448835729372 0.9198431529145892 8.423846297371146 0.9995398172280815 0.050523757229823156 0.08152230588192105 0.02805674431967911 0.05920143124890129 0.3314572751784168 1.1090686064987431e-07 6.955041587753237 7.504003144456556 DVFRDPALK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVFRDPALKR 10 2 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 59649500.0 7368500.0 13372000.0 38909000.0 True False 9538668.504849687 12627836.445067292 31827961.240053933 1.0 1.3238573537435543 3.3367299874056675 23.18535646495586 -6.935094300934666 0.703729900814117 0.9743944854809412 3.8092154446899307 0.9974480119425241 0.0522197047051182 0.09007772663938722 0.06534742743414566 0.04910926201776809 0.1773073671165152 1.1611964489976047e-07 6.935094300934666 2.8348209592089892 up DVGAQILLHSHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVGAQILLHSHK 12 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 269837000.0 67528000.0 93109000.0 109200000.0 False True 88529861.94208232 79217500.13603938 97901031.52036549 1.0 0.8948110659865793 1.105853204474824 26.399660835893187 -6.7711634398571485 1.5698306291221518 0.9397574412544313 1.1070979112865758 0.7350728988508226 0.04434630727075166 0.2645407480753654 1.2867311428430894 0.022263779712116093 0.05294433797656612 1.693700283190096e-07 6.7711634398571485 0.16734047003214447 DVGAQILLHSHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVGAQILLHSHK 12 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 144456000.0 47237000.0 21386000.0 75833000.0 False True 45737487.29122654 29925541.3265167 55970062.35876447 1.0 0.6542891422077984 1.2237240319386928 25.446873773903814 -6.742333909144368 1.6780709030778098 0.7948726204788136 1.2242402771158705 0.6155129543162715 0.1452465856213699 0.31355658922684687 1.7345316370854476 0.06844933276221744 0.1675453440020197 1.8099479713864502e-07 6.742333909144368 0.4293676566370569 DVGAQILLHSHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVGAQILLHSHK 12 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 219210000.0 51193000.0 110170000.0 57847000.0 False True 77663523.70961595 90509302.73786117 46413515.0947592 1.0 1.165402989906505 0.5976230909673815 26.210733830163317 -6.828768809418724 1.3336375484808074 1.0884554787640248 0.5827502488475875 0.9033428861813196 0.07412720419351197 0.1823382443349541 0.6347261295926567 0.04364946096651838 0.10044358810643624 1.4833074929691546e-07 6.828768809418724 -0.5057052299164373 DVGAQILLHSHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVGAQILLHSHK 12 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 168517000.0 67528000.0 34325000.0 66664000.0 False True 92494926.47558331 32808408.002404083 50919336.18817679 1.0 0.35470494709852873 0.5505095049901835 26.462870897416078 -10.369141472419637 6.627039384189296 1.000036105615419 0.4526072260443878 0.912438656623392 0.0799368760243006 4.264536212661824e-05 4.059522349292883e-06 0.07740362849103169 0.025799515799163588 4.274236292475029e-11 10.369141472419637 -0.5474288795710311 DVGAQILLHSHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVGAQILLHSHK 12 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 105282000.0 47237000.0 33915000.0 24130000.0 False True 39279658.45391639 33732293.16339958 29175471.435485702 1.0 0.8587725680704407 0.742762859552735 25.22727904933809 -6.973375224077578 0.15795983276918635 1.120750141708418 0.47771281982115094 0.9999981680184179 0.0001422511247861788 0.07522197195246755 0.004866024589098045 0.005475765912494638 0.014027494536662476 1.0632240112890161e-07 6.973375224077578 -0.6430373218872671 DVGAQILLHSHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVGAQILLHSHK 12 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 202083000.0 51193000.0 99163000.0 51727000.0 False True 66270347.66489383 93644491.87871741 42313216.76384049 1.0 1.4130677622553776 0.6384939607953131 25.981860152255766 -6.761835256952075 1.6055455509419274 1.2393861729040476 0.6354034949892869 0.6984111328100675 0.17378622176296882 0.27985048220813596 1.4221898664055272 0.08538615847615813 0.2048276038369692 1.730472663378752e-07 6.761835256952075 -0.6039826779147607 DVGAQILLHSHKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVGAQILLHSHKK 13 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 22465500.0 7266700.0 4760800.0 10438000.0 False True 9526714.0708229 4050507.197453053 9357975.888366085 1.0 0.42517358738186395 0.9822878926351318 23.183547258675436 -10.8895876169497 10.664334920062757 1.0196884696483886 0.703730740008499 0.27382110754990596 0.22744096271260933 0.09204956566508715 0.0009530264478804947 0.19039676286697615 0.07340625506927648 1.2894733862252187e-11 10.8895876169497 -0.31595772963988955 DVGAQILLHSHKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVGAQILLHSHKK 13 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 8944610.0 2310400.0 976410.0 5657800.0 False True 2237057.6166490177 1366295.6049108852 4175852.4496382424 1.0 0.610755661697045 1.8666718365052335 21.093170983603798 -6.823461307257645 1.3568370191546784 0.7909030401169356 1.8961785828786673 0.8921605028088546 0.17238112798465227 0.18902020391089497 0.6828115067820107 0.09981148544071108 0.2298641960109627 1.5015461775467017e-07 6.823461307257645 1.1052755427617318 DVGAQILLHSHKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVGAQILLHSHKK 13 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 98433000.0 10939000.0 46847000.0 40647000.0 False True 16595262.748021996 38486786.83271834 32613102.63378705 1.0 2.319142963693396 1.9652055607058247 23.984268135584212 -10.530784607843001 5.181700580913936 0.9957694319715914 2.142174262199617 0.9328189474512751 0.1444943397009314 0.007069934442825155 0.0006401988098951704 0.1400645649233861 0.046635347606906845 2.945882307717267e-11 10.530784607843001 1.1464048302280254 DVGAQILLHSHKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVGAQILLHSHKK 13 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 20609400.0 7266700.0 7336700.0 6006000.0 False True 9953395.365183635 7012540.334777513 4587506.49745274 1.0 0.7045375047902697 0.4608986510773555 23.246757320198327 -7.195981348748407 0.17655000582616143 1.2129330350646543 4.0283093644481784e-11 0.999993251062305 0.0005726091452318848 0.09062737383986394 0.0080777312230806 0.01541600359516289 0.03690918146221776 6.368228693753924e-08 7.195981348748407 -1.2129330350243712 down DVGAQILLHSHKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVGAQILLHSHKK 13 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 5758860.0 2310400.0 2581300.0 867160.0 False True 1921199.9680743548 2567394.024552067 1048479.146705171 1.0 1.3363491917634172 0.5457418093526599 20.873576259038074 -6.791118271413167 1.491963508344638 1.1877100693639144 0.5370834366643925 0.80490911068875 0.143089484444833 0.2336813721153096 1.0275904856053546 0.07548693582345918 0.17658277729278962 1.6176394459138218e-07 6.791118271413167 -0.6506266326995219 DVGAQILLHSHKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVGAQILLHSHKK 13 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 126806000.0 10939000.0 61001000.0 54866000.0 False True 14160751.13992684 57606240.7258114 44880950.97270033 1.0 4.068021544661438 3.1693905591036464 23.755394457676662 -10.053580660868123 5.078081383705535 0.9999590657878262 3.6187060518940153 0.9188488609796477 0.36686456365170583 0.0001700228234104493 3.16862125870995e-05 0.3552205493891452 0.11840502877233917 8.839329823958871e-11 10.053580660868123 2.618746986106189 DVGAQILLHSHKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVGAQILLHSHKK 13 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 1 6344800.0 2070300.0 2245100.0 2029400.0 True False 1721546.1798408683 2233005.200682543 2453738.157114574 1.0 1.2970928266873165 1.42531068050779 20.715273450513052 -12.606470676988057 0.12962764439816152 4.0463357374849846e-15 1.6197566302950366 0.9996830679513408 0.003171282937864424 7.17032120906847 0.09831342349603034 2.0307102272747755 0.1574546282423943 2.474738546897262e-13 12.606470676988057 1.6197566302950326 DVGRPQPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVGRPQPGR 9 1 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 8922200.0 2634200.0 1696600.0 4591400.0 False True 2550578.7628881787 2374061.227652122 3388774.6009524963 1.0 0.9307931447542616 1.328629662514392 21.282393221744456 -6.862021052389836 1.17537746699471 0.9622263126467085 1.3486615107441196 0.9560562845719693 0.03637982418524504 0.14474021146535737 0.37880513314455366 0.024118895964945083 0.056439009063052596 1.3739753700534106e-07 6.862021052389836 0.386435198097411 DVGTEK(ub)LK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVGTEKLK 8 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 50890000.0 13032000.0 21951000.0 15907000.0 True False 17085078.20206752 18675996.36432782 14261096.230718466 1.0 1.0931174059283952 0.8347106206978137 24.026233515518477 -6.809210174078361 1.4176539576013465 1.05079521022942 0.8302622344192879 0.8578177317993854 0.04029258434331811 0.20786945445119195 0.8234949836420903 0.02234847911254862 0.05172010256664758 1.5516359238013777e-07 6.809210174078361 -0.2205329758101321 DVGTEK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVGTEKLK 8 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 54798000.0 12807000.0 21745000.0 20246000.0 True False 12400448.79519737 30427891.898676924 14942965.233019192 1.0 2.4537734400759343 1.2050342273746193 23.563888999572786 -6.609085752121969 2.15608743521641 1.9718008081255716 1.2093637832625062 0.047870146554479076 0.6268985080471967 0.6151566670062655 5.417197109598834 0.24015642508793145 0.6964810676568475 2.4598818486897457e-07 6.609085752121969 -0.7624370248630654 DVGTEK(ub)LK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVGTEKLK 8 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 85518000.0 13404000.0 12823000.0 59291000.0 True False 20334847.963660926 10534635.46344371 47572107.86183155 1.0 0.518058235904663 2.339437597312975 24.277450868540356 -6.836360214877651 1.2993099140790505 0.7433862519810216 2.3951099869142616 0.9179905993143359 0.2206657854799135 0.1730961991721765 0.5692285948716169 0.13325004906653762 0.306727910487281 1.4576047843173575e-07 6.836360214877651 1.65172373493324 up DVGTEK(ub)LK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVGTEKLK 8 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 46795000.0 13032000.0 17030000.0 16733000.0 True False 17850282.576557882 16277558.289320944 12781010.026952505 1.0 0.9118935915724752 0.7160116357898633 24.08944357704137 -6.957924105745289 0.4637700697638601 1.0054996523127824 0.6144591491357289 0.999685269949448 0.002105594788092386 0.08045126535387313 0.023936158973224774 0.0026777590111913396 0.01617558063230295 1.101731823638555e-07 6.957924105745289 -0.3910405031770535 DVGTEK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVGTEKLK 8 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 51790000.0 12807000.0 21119000.0 17864000.0 True False 10649587.946298601 21005227.755206738 21599279.806196306 1.0 1.9723981679974172 2.028179861522568 23.344294275007062 -10.97866590284224 0.5061074656632307 1.015892584909383e-12 2.02546262065695 0.9997881915605399 0.006870630500683969 2.7763548759760677 0.24594981763728999 3.258016430879162 0.011212709554338465 1.0503501387810672e-11 10.97866590284224 2.025462620655934 DVGTEK(ub)LK(ub)SEVVSPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVGTEKLKSEVVSPR 15 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 2 19063200.0 4734800.0 7519200.0 6809200.0 True False 6207368.651868419 6397364.66961204 6104649.302458552 1.0 1.0306081414524062 0.983452030132132 22.565550398573183 -6.731479834968813 1.717606275057858 1.0183888881157879 0.983471119011576 0.566245064457978 0.012865477113872238 0.333455147038363 1.9278784170390846 0.005933917616223938 0.01470128560835706 1.85575297319891e-07 6.731479834968813 -0.03491776910421185 DVGTEK(ub)LK(ub)SEVVSPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVGTEKLKSEVVSPR 15 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 2 27164900.0 7496200.0 7386700.0 12282000.0 True False 7258237.23421243 10336247.83113162 9064975.74789795 1.0 1.424071368515027 1.248922493903792 22.791187781146718 -10.130494893251672 5.149993610506339 0.9999888047096179 1.33649693120983 0.8311202372922697 0.07150422863817138 9.19152831570876e-06 1.5520054357789898e-06 0.06923597420149122 0.02307789055804319 7.40465974333676e-11 10.130494893251672 0.3365081265002121 DVGTEK(ub)LK(ub)SEVVSPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVGTEKLKSEVVSPR 15 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 2 22000400.0 4734800.0 7469300.0 9796300.0 True False 6485383.513158854 7139281.628327947 7482615.70113158 1.0 1.100826437456217 1.153766108966315 22.628760460096075 -13.999992556994252 0.08103531634702203 0.45966594047507203 1.308871624653717 0.9998823603239332 0.0006917605493601114 12.248280581091318 0.08039535528615568 1.180800474642743 0.14068288296682255 1.0000171383009407e-14 13.999992556994252 0.8492056841786451 DVGTEK(ub)LK(ub)SEVVSPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVGTEKLKSEVVSPR 15 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 2 26668000.0 7496200.0 11350000.0 7821800.0 True False 6233422.437967021 11288855.29720139 9457302.216082985 1.0 1.811020416078708 1.5171925712077048 22.571593056580994 -10.072500123097765 4.36479196568923 0.9999424579141941 1.664106493564403 0.8719798937397583 0.11995471560801477 83929783.24020875 145479689.96482778 68154.07491966287 0.04389892139829838 8.462523289428705e-11 10.072500123097765 0.6641640356502089 DVHLSK(ub)EQESR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVHLSKEQESR 11 1 Q86U86-5;Q86U86-4;Q86U86-7;Q86U86-3;Q86U86-9;Q86U86-2;Q86U86-8;Q86U86 Q86U86-5 PBRM1 Protein polybromo-1 1 21693600.0 6214400.0 9474800.0 6004400.0 True False 8147138.580335205 8061196.77248114 5383122.286271829 1.0 0.9894512893076959 0.6607377833568588 22.95786201752479 -6.913732615016729 0.8699210873962203 1.00901591760351 0.6146810081921118 0.9922557532881591 0.013860419671304225 0.10200142095726232 0.12575820950864633 0.011561437895375212 0.03280417428301086 1.2197403334710681e-07 6.913732615016729 -0.39433490941139826 DVHLSK(ub)EQESR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVHLSKEQESR 11 1 Q86U86-5;Q86U86-4;Q86U86-7;Q86U86-3;Q86U86-9;Q86U86-2;Q86U86-8;Q86U86 Q86U86-5 PBRM1 Protein polybromo-1 1 27005300.0 9518800.0 10206000.0 7280500.0 True False 9216630.904327698 14281309.023586884 5373518.6396817295 1.0 1.5495151288830553 0.5830241761291077 23.135808046020976 -6.752468244909857 1.64067797395558 1.3221563312338478 0.5807310533291431 0.6595497381642994 0.2309436208586725 0.29575272659488644 1.5670744435161312 0.11116020823537222 0.2691747244264792 1.7682015017747135e-07 6.752468244909857 -0.7414252779047047 DVHLSK(ub)EQESR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVHLSKEQESR 11 1 Q86U86-5;Q86U86-4;Q86U86-7;Q86U86-3;Q86U86-9;Q86U86-2;Q86U86-8;Q86U86 Q86U86-5 PBRM1 Protein polybromo-1 1 18920300.0 6214400.0 7489900.0 5216000.0 True False 8512031.617845401 7158971.452212857 3984088.226892024 1.0 0.8410414544518532 0.4680537391965764 23.02107207904768 -6.956805317964986 0.4783366773483794 1.0090944085677453 0.2844935951290032 0.9996327490283669 0.004272535901984691 0.08086270071188355 0.025502590415219382 0.005241404426251194 0.030770281916803532 1.1045736583274743e-07 6.956805317964986 -0.7246008134387422 down DVHMPK(ub)HPELADK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVHMPKHPELADK 13 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;P46783;Q9NQ39 A0A1W2PQS6;P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 6535300.0 1982300.0 2272700.0 2280300.0 True False 2598814.496620506 1933622.0189152164 2044356.4301821394 1.0 0.7440400311102217 0.7866496176778361 21.309422227237032 -10.212270040549019 5.372534955322607 1.0000137506552895 0.765344824394014 0.9758672713487202 0.017395290873725284 2.86524761613945e-06 4.201122925812187e-07 0.01684390461420033 0.005614305988012958 6.13380491886639e-11 10.212270040549019 -0.23466892626127556 DVHMPK(ub)HPELADK ddPTM_RPMI8226_Bortezomib_2h_R1 2 DVHMPKHPELADK 13 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;P46783;Q9NQ39 A0A1W2PQS6;P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 11050890.0 2577710.0 3152410.0 5320770.0 True False 2495882.007017119 4411183.75260098 3927100.7173215165 1.0 1.7673847322105096 1.5734320397681287 21.251118301635326 -10.088119962305353 4.648389118549451 0.9999629484964488 1.6704083859540306 0.9409345609658495 0.0791808551799095 41615315.26573322 1.3997567924764645 17232.0741598035 0.028977225870241676 8.163568433360034e-11 10.088119962305353 0.6704454374575818 DVHMPK(ub)HPELADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVHMPKHPELADK 13 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;P46783;Q9NQ39 A0A1W2PQS6;P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 5710300.0 1982300.0 1734300.0 1993700.0 True False 2715209.879643237 1657672.8914368348 1522829.1215403825 1.0 0.6105137226646521 0.5608513481618862 21.372632288759924 -13.999999999999998 0.2903868733050444 4.3635199465547005 0.5473708587559193 0.9996283276401271 0.0037855939604666475 15.98861801393145 0.17089458919526765 32.13342704727478 0.018723325137199126 1.0000000000000041e-14 13.999999999999998 -3.8161490877987814 DVHMPK(ub)HPELADK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 DVHMPKHPELADK 13 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;P46783;Q9NQ39 A0A1W2PQS6;P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 10670290.0 2577710.0 6058800.0 2033780.0 True False 2143480.076915233 6026160.041822364 2459033.9948637453 1.0 2.8113907410302823 1.1472156990619846 21.031523577069603 -6.62603575730525 2.094905451916013 2.19679602261434 1.153801359593898 0.10341079358091432 0.7777708449338435 0.5693752895083997 4.75645938189197 0.3042114924701299 0.8618101641706613 2.3657249093091913e-07 6.62603575730525 -1.042994663020442 DVHNIYGLYVHMATADGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVHNIYGLYVHMATADGLR 19 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 34940900.0 14876100.0 9637600.0 10427200.0 False True 14403866.348265449 13485943.939420063 7696003.510705205 1.0 0.9362724988797244 0.534301230282658 23.779952782321597 -6.934786632068195 0.7064027893864696 1.005164255334549 0.44073002452330323 0.9973980876687314 0.010516001262635976 0.09022771055886786 0.066056737137567 0.009869706965601226 0.03546324300528663 1.1620193712057598e-07 6.934786632068195 -0.5644342308112458 DVHNIYGLYVHMATADGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVHNIYGLYVHMATADGLR 19 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 246408000.0 58997000.0 81775000.0 105636000.0 False True 89502762.25843787 67181612.33900872 84756998.29809651 1.0 0.7506093738763372 0.9469763408347327 26.41542887211977 -9.89588337007844 5.546756771170058 1.000000113581077 0.848792857568191 0.4415221161949706 0.08016647856622032 109350092.66126788 17.937095475827277 158.64879670205138 0.027443117916255626 1.270915364110072e-10 9.89588337007844 -0.15120725601288598 DVHNIYGLYVHMATADGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVHNIYGLYVHMATADGLR 19 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 11150700.0 1484400.0 2194400.0 7471900.0 False True 2033222.794401668 2097444.1520896023 5707191.108610919 1.0 1.031585991394924 2.806967895660651 20.955336879326016 -6.910758446582034 0.8905566611284562 0.9463405298479791 3.0401656085330515 0.9912045928189459 0.07919729525269184 0.10391853484989835 0.13606355803686188 0.06508402994886599 0.18061900317651897 1.2281221194366223e-07 6.910758446582034 2.0938250786850725 up DVHNIYGLYVHMATADGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVHNIYGLYVHMATADGLR 19 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 29176300.0 14876100.0 7251200.0 7049000.0 False True 12370136.272970455 7212136.346349492 8522913.309106465 1.0 0.5830280432810167 0.6889910604889277 23.560358057755874 -10.004391775038377 7.041910086503613 1.0000000354900316 0.6360095518849769 0.9402376629213814 0.0432592206275237 2.4081366807626023e-08 3.456675795526194e-09 0.04188556400992445 0.013961853421692472 9.899385230260447e-11 10.004391775038377 -0.3639904836050547 DVHNIYGLYVHMATADGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVHNIYGLYVHMATADGLR 19 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 214251000.0 58997000.0 88721000.0 66533000.0 False True 76372779.5047319 83783598.35797298 54424676.68622954 1.0 1.0970348192287793 0.712618776469403 26.186555194212218 -6.8398035042935685 1.283216014907357 1.051623237828759 0.7000169940231908 0.9241298437177362 0.04495936636786786 0.16902859144373494 0.5407292915569469 0.0274733145978457 0.06329311432386972 1.446093905171188e-07 6.8398035042935685 -0.35160624380556826 DVIAQSQSGTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVIAQSQSGTGK 12 0 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 6012300.0 1793900.0 0.0 4218400.0 False True 1736953.626431214 0.0 3113474.4907126427 1.0 0.0 1.7924914305914206 20.728127806498097 -6.75528701732598 1.6300587958673867 0.4157476359773776 1.7975918426591693 0.6714799138183705 0.4203686399207857 0.2909143242709557 1.52229051363834 0.2035786538046947 0.4915649161148843 1.7567622180229015e-07 6.75528701732598 1.3818442066817918 DVIATDKEDVAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVIATDKEDVAFK 13 1 P40925;P40925-3;A0A5K1VW95;C9JF79;C9JRL4;C9JLV6 P40925 MDH1 Malate dehydrogenase, cytoplasmic;Malate dehydrogenase 0 21425500.0 3953700.0 7145800.0 10326000.0 False True 5183338.987685259 6079674.494110236 9257564.573986223 1.0 1.1729262756216636 1.786023371417659 22.30545031764067 -6.947649118209902 0.5840932805417309 0.9927782660210599 1.9967095637149324 0.999003564508993 0.010645683885001096 0.08444389832621016 0.039978345536765006 0.01110512101788844 0.05127374211415977 1.1281085266477371e-07 6.947649118209902 1.0039312976938723 DVIATDKEDVAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVIATDKEDVAFK 13 1 P40925;P40925-3;A0A5K1VW95;C9JF79;C9JRL4;C9JLV6 P40925 MDH1 Malate dehydrogenase, cytoplasmic;Malate dehydrogenase 0 14963800.0 3953700.0 5219500.0 5790600.0 False True 5415489.734725048 4988885.231421655 4422979.541150489 1.0 0.9212251293603362 0.816727527482803 22.36866037916356 -6.96721897520005 0.31767245304470687 1.0147074751790899 0.7198861738643212 0.9999518447519701 0.0005208803042518669 0.07721580917543366 0.012245941786342456 0.001599192304746285 0.009210994844629597 1.0784028446736221e-07 6.96721897520005 -0.2948213013147687 DVICLIK(ub)CLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVICLIKCLR 10 1 Q12769;G3V198;E9PR16;Q12769-3 Q12769 NUP160 Nuclear pore complex protein Nup160 1 10065400.0 2382000.0 2462000.0 5221400.0 True False 3122825.0673208116 2094679.1968008352 4681139.6152054705 1.0 0.6707641803957782 1.4990079541091923 21.574420324857073 -6.798845005857934 1.4606410690184237 0.8180789849616295 1.5101156409752856 0.8287598903322629 0.14089819666320402 0.2224106081854645 0.9369120921136495 0.07589190822889547 0.17662088230863246 1.5891137817780043e-07 6.798845005857934 0.6920366560136562 DVICLIK(ub)CLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVICLIKCLR 10 1 Q12769;G3V198;E9PR16;Q12769-3 Q12769 NUP160 Nuclear pore complex protein Nup160 1 5949600.0 0.0 5949600.0 0.0 True False 0.0 4887847.3955630325 0.0 0.0 DVICLIK(ub)CLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVICLIKCLR 10 1 Q12769;G3V198;E9PR16;Q12769-3 Q12769 NUP160 Nuclear pore complex protein Nup160 1 11463900.0 2382000.0 3579300.0 5502600.0 True False 3262689.7711295923 3421154.690837725 4202999.209604306 1.0 1.0485687977785487 1.2882006885224533 21.637630386379964 -6.940102777965097 0.6586071986660852 0.9973149004364283 1.3530175228183388 0.9981773261073247 0.005378497305483779 0.08771976436588279 0.05439647174159722 0.005239650266877538 0.020615312490616006 1.1478819373387138e-07 6.940102777965097 0.3557026223819104 DVIEEYFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVIEEYFK 8 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 29109200.0 2602200.0 14128000.0 12379000.0 False True 3411509.3997406424 12020157.47051268 11098139.827752795 1.0 3.5234132643534575 3.2531464895264612 21.701978760689855 -9.646208201149562 6.974684777173665 1.000000003291019 3.388279876940848 0.990486838858604 0.11033594879551839 1.6503123701943013e-09 4.5648677820713366e-10 0.10683232304182909 0.03561077434727635 2.2583528543582423e-10 9.646208201149562 2.388279873649829 DVIEEYFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVIEEYFK 8 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 27707800.0 9997300.0 2938500.0 14772000.0 False True 9679941.18374535 4111858.3740750644 10902770.049499119 1.0 0.4247813386490133 1.1263260636136048 23.2065668508967 -6.688805766493416 1.8707089887271178 0.6389703586494181 1.123863825613175 0.3648227050930849 0.2433364413083803 0.41923849288442194 2.8436134351165006 0.10409749055059449 0.27148091130698504 2.047360091637804e-07 6.688805766493416 0.4848934669637569 DVIEEYFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVIEEYFK 8 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 28360200.0 2602200.0 13208000.0 12550000.0 False True 3564303.6618108395 12624426.88698478 9585948.47536328 1.0 3.5419055402734565 2.6894309197250474 21.765188822212746 -10.057033114473521 5.77112922347262 0.9999923534831668 3.1156682299995797 0.8914508438971677 0.3480213065038797 3.423967824480937e-05 5.59454677829718e-06 0.3369714026701945 0.11232339368440339 8.76933953351112e-11 10.057033114473521 2.1156758765164128 DVIEEYFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVIEEYFK 8 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 13353100.0 9997300.0 1501900.0 1853900.0 False True 8313197.905483801 1493808.966596192 2241541.918534893 1.0 0.17969125522812357 0.26963653987549846 22.986972126330976 -10.509640389458557 6.233676910254202 1.0006803723010078 0.22466389813745702 0.990007445571785 0.03672000869257642 0.0003474839268504184 2.7334165040708127e-05 0.03558178153725973 0.011851331844911663 3.092855361513925e-11 10.509640389458557 -0.7760164741635508 DVIEEYFK(ub)CK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVIEEYFKCK 10 1 P25398 P25398 RPS12 40S ribosomal protein S12 1 207776000.0 97704000.0 93024000.0 17048000.0 True False 94602440.00046559 130168968.31375153 12582617.370962711 1.0 1.3759578327272628 0.1330052097060159 26.495374058465156 -6.825578869919515 1.3475205571139626 1.201584097431516 0.10247631547143402 0.8967346207318079 0.16725110767381005 0.18633913201768887 0.6632659917119195 0.09749232395877826 0.22444610373045595 1.494242656233956e-07 6.825578869919515 -1.0991077819600819 down DVIEEYFK(ub)CK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVIEEYFKCK 10 1 P25398 P25398 RPS12 40S ribosomal protein S12 1 343314000.0 165830000.0 102160000.0 75324000.0 True False 251576233.79691797 83928749.82027687 60436178.38431798 1.0 0.3336115997667228 0.2402300784624369 27.90642039752108 -13.999999999999998 0.27685082223650304 6.33794421291517 0.21123468956845728 0.9995982315472552 0.00678100992987212 15.23051272765743 0.1666356976971135 45.945482147424336 0.03750026987110919 1.0000000000000041e-14 13.999999999999998 -6.126709523346713 DVIEEYFK(ub)CK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVIEEYFKCK 10 1 P25398 P25398 RPS12 40S ribosomal protein S12 1 4693300.0 2509500.0 0.0 2183800.0 True False 3437329.9666875396 0.0 1668031.416772776 1.0 0.0 0.4852695065467375 21.71285691927536 -9.931338994523452 5.8661459262272135 1.0000004077406108 0.24263475327296266 0.7645816163019142 0.1981104464633958 1.0565502824430853e-06 1.9246768747088963e-07 0.19181971785904173 0.06393987165499244 1.171280749358469e-10 9.931338994523452 -0.7573656544676481 DVIEEYFK(ub)CK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVIEEYFKCK 10 1 P25398 P25398 RPS12 40S ribosomal protein S12 1 178506800.0 97704000.0 56682800.0 24120000.0 True False 81245205.02109452 56377438.50574514 29163380.481720477 1.0 0.6939171178299974 0.35895509740111425 26.275779333899433 -7.09473647812462 0.27510789629154747 1.0841450252791514 4.215374362361193e-15 0.9999716818806054 0.0013931187969740482 0.07587224683227768 0.010920007154883275 0.0075418224125397 0.03179012965433802 8.040138349576062e-08 7.09473647812462 -1.0841450252791471 down DVIEEYFK(ub)CK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVIEEYFKCK 10 1 P25398 P25398 RPS12 40S ribosomal protein S12 1 301314000.0 165830000.0 99272000.0 36212000.0 True False 214670203.9979949 93747425.93289854 29621787.56649704 1.0 0.43670441536345755 0.1379874198413382 27.67754671961353 -8.763622126881188 0.3000426684517182 1.212338039047984 5.188423391473841e-19 0.9986546706035057 0.013108901264381391 0.30852759903321425 0.09450064565099796 0.1683937298671527 0.09656904850169525 1.7233673989806037e-09 8.763622126881188 -1.212338039047984 DVIEEYFK(ub)CKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVIEEYFKCKK 11 2 P25398 P25398 RPS12 40S ribosomal protein S12 1 49095000.0 14113000.0 21081000.0 13901000.0 True False 21410452.798503883 17318930.843395215 11153461.256975261 1.0 0.8089007274337245 0.5209353282689398 24.35181197106286 -6.96518107774195 0.35493298274629637 1.0262955027842882 0.29374951035257446 0.9999168264066989 0.001795760118177015 0.07789959847479702 0.014643723417756023 0.0039059540270889536 0.024672560482794884 1.0834750682489041e-07 6.96518107774195 -0.7325459924317137 DVIELTDDSFDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVIELTDDSFDK 12 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 11252500.0 2915200.0 1619800.0 6717500.0 False True 2822658.571699802 2266594.587145412 4957985.229319683 1.0 0.8029999128730866 1.756494844622313 21.42862320051868 -6.852825036487815 1.22133339746616 0.8945602630868043 1.7967508223368742 0.9443224625529674 0.09697855270335011 0.1543763392710872 0.44170320363109006 0.062084311368172204 0.1439547849788057 1.4033789676951833e-07 6.852825036487815 0.90219055925007 DVIK(ub)QAQNEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVIKQAQNEK 10 1 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 26659700.0 11353000.0 8557900.0 6748800.0 True False 14883892.942608386 7281094.67843293 6050498.915060834 1.0 0.48919289506505453 0.4065131977494922 23.82724858275726 -13.999999999999998 0.2562781317437385 4.667915880224744 0.3751994289082263 0.9995548357944147 0.005537703697282686 14.255725965923192 0.16019016769249592 27.019277039462168 0.036869127060688615 1.0000000000000041e-14 13.999999999999998 -4.292716451316517 DVIK(ub)QAQNEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVIKQAQNEK 10 1 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 36673000.0 10223000.0 13153000.0 13297000.0 True False 9898476.46078728 18405061.491988856 9814116.798550626 1.0 1.8593832661925633 0.9914775104460931 23.238775056979797 -10.410892143723414 3.7708309207458575 0.9974782765648523 1.4254303881826347 0.24263601235081245 0.35432104172566603 43735281.83723694 60400335.22897301 760858.9791584577 0.12129326009319168 3.882467744275228e-11 10.410892143723414 0.42795211161778235 DVIK(ub)QAQNEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVIKQAQNEK 10 1 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 52375000.0 12829000.0 11449000.0 28097000.0 True False 19462530.925530143 9405836.498554718 22543615.634647436 1.0 0.48327920631414545 1.158308532477431 24.214195995928105 -6.702161733788062 1.8232270156150086 0.6798189994021698 1.1563799280248095 0.42782549316323315 0.21802906949686932 0.39103608413653923 2.5286133585591797 0.09534950556131612 0.24455550035487295 1.985355421776851e-07 6.702161733788062 0.47656092862263966 DVIK(ub)QAQNEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVIKQAQNEK 10 1 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 26386200.0 11353000.0 7909100.0 7124100.0 True False 15550510.903288946 7559649.810103833 5441534.305445064 1.0 0.48613514096858135 0.3499264004434848 23.89045864428015 -13.999999999999998 0.18637776823630747 3.721038480445215 0.2485658945492013 0.9994918146648774 0.00631026363160936 12.293978407324538 0.13689712193471945 12.134689097630785 0.09644319557874399 1.0000000000000041e-14 13.999999999999998 -3.4724725858960133 DVIK(ub)QAQNEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVIKQAQNEK 10 1 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 42989000.0 10223000.0 21672000.0 11094000.0 True False 8500877.455689121 21555248.634444825 13413704.107139602 1.0 2.5356498487128767 1.5779199473299812 23.019180332414074 -9.946291643004686 5.785749937399282 0.9999991537601364 2.056784898022097 0.6188154397623745 0.39099159496805785 4.268515681219236e-06 7.761171295600607e-07 0.378576282888839 0.12619199465118505 1.1316401744836243e-10 9.946291643004686 1.0567857442619606 DVIK(ub)QAQNEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVIKQAQNEK 10 1 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 59284000.0 12829000.0 17279000.0 29176000.0 True False 16607393.397396605 16317408.460538281 23866267.371040437 1.0 0.9825388048612262 1.437086892563269 23.985322318020554 -6.897964929964268 0.9740264912138809 0.9800312109010701 1.4828782402358038 0.9855264781662463 0.025298084212127318 0.112920320882915 0.18598229969321964 0.01955138649125154 0.05037027815938394 1.2648384812574163e-07 6.897964929964268 0.5028470293347337 DVITGLK(ub)QK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVITGLKQK 9 1 P04839 P04839 CYBB Cytochrome b-245 heavy chain 1 7965100.0 1692100.0 2245000.0 4028000.0 True False 1638385.211708711 3141440.207520336 2972945.962590203 1.0 1.917400245723686 1.814558591803723 20.643843167868724 -10.033255845026785 4.633344432615461 0.9999717562594721 1.8659794187883656 0.9895331837252545 0.041984929536392664 6362410.708038544 4592485.376718886 1656.0874719596766 0.014372558546016602 9.262839841414988e-11 10.033255845026785 0.8660076625288935 DVITGLK(ub)QK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVITGLKQK 9 1 P04839 P04839 CYBB Cytochrome b-245 heavy chain 1 6294000.0 1692100.0 2313700.0 2288200.0 True False 1407056.1227400526 2301235.63886651 2766652.040558576 1.0 1.6354966953167176 1.9662698565078507 20.424248443303 -9.930273867149962 0.15161880068780037 6.346651784181278e-16 2.4558424377085304 0.9997285062951701 0.0066066968351554895 1.477986508368708 0.06924376816618745 0.8809600912700468 0.2848922081916383 1.1741568952571371e-10 9.930273867149962 2.45584243770853 DVITGLK(ub)QK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVITGLKQK 9 1 P04839 P04839 CYBB Cytochrome b-245 heavy chain 1 10251700.0 1596200.0 3229500.0 5426000.0 True False 2066312.3658059416 3049775.4860413414 4438523.675461527 1.0 1.4759508467887483 2.1480409975334642 20.978626933176244 -6.966241315880513 0.3360668982403432 0.9236995691051243 2.722495322901782 0.999936494026094 0.0037531081902906945 0.07754220801127293 0.013388345554693289 0.00960603164408924 0.058343311666227214 1.0808332190592882e-07 6.966241315880513 1.7987957537966577 DVK(ub)GSYVSIHSSGFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVKGSYVSIHSSGFR 15 1 Q13838-2;Q13838;Q5STU3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;F6R6M7;A0A0G2JHN7;F6SXL5;F6S2B7;F6U6E2;F6QYI9;A0A0G2JJL7 Q13838-2;F6QYI9 DDX39B Spliceosome RNA helicase DDX39B 1 14968100.0 5221100.0 6694100.0 3052900.0 True False 6844912.661204327 5695366.373397423 2737015.19348465 1.0 0.8320582972048255 0.3998612296395739 22.706600702618704 -6.954837983681714 0.5029385409098801 1.0084394312054876 0.2047457639872963 0.9995282725322562 0.005490607676040377 0.08159932683976198 0.02835835583816216 0.006404033281107 0.03565637246227681 1.1095886771729263e-07 6.954837983681714 -0.8036936672181914 down DVK(ub)GSYVSIHSSGFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVKGSYVSIHSSGFR 15 1 Q13838-2;Q13838;Q5STU3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;F6R6M7;A0A0G2JHN7;F6SXL5;F6S2B7;F6U6E2;F6QYI9;A0A0G2JJL7 Q13838-2;F6QYI9 DDX39B Spliceosome RNA helicase DDX39B 1 14789000.0 5221100.0 6425600.0 3142300.0 True False 7151481.764922222 6141695.745382309 2400153.4576999242 1.0 0.8588004482521538 0.33561624521964056 22.769810764141596 -6.946634861948013 0.5946440618666238 1.0059692914852545 0.16191074673096656 0.9989100249317708 0.009435170627630088 0.08486587351955314 0.04177676047472199 0.009735571291676211 0.04389203985513004 1.1307462029345995e-07 6.946634861948013 -0.8440585447542879 down DVK(ub)GSYVSIHSSGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVKGSYVSIHSSGFR 15 1 Q13838-2;Q13838;Q5STU3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;F6R6M7;A0A0G2JHN7;F6SXL5;F6S2B7;F6U6E2;F6QYI9;A0A0G2JJL7 Q13838-2;F6QYI9 DDX39B Spliceosome RNA helicase DDX39B 1 17541700.0 7612400.0 7342100.0 2587200.0 True False 6330047.886499836 7302546.650007256 3128171.5581387742 1.0 1.1536321337444349 0.4941781822551865 22.59378498293585 -6.845353906246152 1.257371796693266 1.0817622713689634 0.4700961740032732 0.9332577695880155 0.07278317493033658 0.16264255724998594 0.49717066287320605 0.04534527789717576 0.10466235822894397 1.427730028208061e-07 6.845353906246152 -0.6116660973656902 down DVK(ub)LAEAHQQECCQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVKLAEAHQQECCQK 15 1 Q9Y5X3;A0A087WUY5 Q9Y5X3 SNX5 Sorting nexin-5 1 13370600.0 3886700.0 4187000.0 5296900.0 True False 5896408.055831157 3439797.1368196867 4249965.393286254 1.0 0.5833716229014977 0.720771926407522 22.491404937677324 -10.343410251691456 4.956876230350764 1.0001935777980389 0.6520717746544105 0.8952828975647875 0.0560934390158944 0.00012006511760767829 1.5903897172376653e-05 0.05434218763436168 0.018104079594955868 4.5351300797279666e-11 10.343410251691456 -0.3481218031436284 DVK(ub)LAEAHQQECCQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVKLAEAHQQECCQK 15 1 Q9Y5X3;A0A087WUY5 Q9Y5X3 SNX5 Sorting nexin-5 1 11488400.0 3886700.0 3217700.0 4384000.0 True False 5031409.768310959 3038632.1664143773 3586156.9836386545 1.0 0.6039325569450575 0.712753909694484 22.262531259769773 -10.219587585555395 7.9217291474114955 1.0000002245816435 0.6583432333197727 0.9292930434459696 0.04442613122591837 1.7618266927951312e-07 1.7396556259820025e-08 0.043015444795991224 0.014338472197867255 6.031320600913798e-11 10.219587585555395 -0.34165699126187077 DVK(ub)NGECFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVKNGECFR 9 1 P41250 P41250 GARS Glycine--tRNA ligase 1 2419030.0 912490.0 921870.0 584670.0 True False 1196283.2265657298 784330.5894211148 524173.95695066015 1.0 0.6556395442179341 0.43816877584704594 20.190127565204456 -8.716812081018396 0.13771729363409002 1.484461422460012 3.0893376503887067e-15 0.9999105763462731 0.002187338548612672 0.26888721169029534 0.03841035258222686 0.21557443120322625 0.16474986792092244 1.919499127211861e-09 8.716812081018396 -1.4844614224600088 DVK(ub)NGECFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVKNGECFR 9 1 P41250 P41250 GARS Glycine--tRNA ligase 1 2679270.0 912490.0 871980.0 894800.0 True False 1249862.2121150475 833453.0403477447 683466.6689844686 1.0 0.6668359378089805 0.5468336128251206 20.253337626727347 -13.999999999999998 0.1421231014876002 2.5947057420417203 0.40205556634322015 0.9995946061373965 0.0038598678247322394 11.936768957396545 0.11826575854274457 5.273205174875023 0.1296232823921763 1.0000000000000041e-14 13.999999999999998 -2.1926501756985 DVK(ub)NGECFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVKNGECFR 9 1 P41250 P41250 GARS Glycine--tRNA ligase 1 8564200.0 1839700.0 2581500.0 4143000.0 True False 2381527.9159085257 2437837.2556791236 3389016.5107698333 1.0 1.0236442073151666 1.4230429499193848 21.18345602917738 -6.919039311582489 0.8318058970189937 0.9908788717060526 1.4860507563600442 0.9939102403559786 0.015146303535262856 0.09874031242757386 0.10856247308981364 0.012984169345500627 0.03854450515333724 1.204926867547248e-07 6.919039311582489 0.49517188465399165 DVK(ub)PSNILVNSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVKPSNILVNSR 12 1 Q02750;Q02750-2;P36507;G5E9C7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 1 26125500.0 5118200.0 10719600.0 10287700.0 True False 6710009.76471931 9120277.46467353 9223227.490586685 1.0 1.3592047976781216 1.3745475511945855 22.677883435228303 -11.86728894544912 0.49264185606475114 7.39196454985762e-13 1.3739119316222776 0.9998832130015156 0.0018702216188725357 5.707899224165795 0.24412591891080937 5.996525662370917 0.0031674260166522214 1.3574100320332417e-12 11.86728894544912 1.3739119316215385 DVK(ub)PSNILVNSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVKPSNILVNSR 12 1 Q02750;Q02750-2;P36507;G5E9C7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 1 28044900.0 6231500.0 6252200.0 15561200.0 True False 6033684.443450639 8748736.06479227 11485254.894006614 1.0 1.4499823692783151 1.9035226322572223 22.524607816061803 -6.971027414395105 0.23234012107714597 0.8208628891448897 2.5456377239547345 0.9999893244486747 0.001205187742524381 0.07597071104254001 0.007827042705248862 0.01145519316940042 0.044843413909659284 1.0689873983563655e-07 6.971027414395105 1.7247748348098448 DVK(ub)PSNILVNSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVKPSNILVNSR 12 1 Q02750;Q02750-2;P36507;G5E9C7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 1 74353600.0 15011600.0 14584000.0 44758000.0 True False 22773694.694963615 11981371.254687926 35911561.681871705 1.0 0.5261057292270453 1.576887815652219 24.440865030595848 -6.784079392350818 1.5197332949776021 0.7330888481046537 1.5863372689962867 0.7816264844411328 0.20078501425188663 0.2442928886684065 1.1145959980442 0.10402797269108273 0.24466407804832357 1.6440711469698422e-07 6.784079392350818 0.853248420891633 DVK(ub)PSNILVNSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVKPSNILVNSR 12 1 Q02750;Q02750-2;P36507;G5E9C7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 1 20549700.0 5118200.0 4392800.0 11038700.0 True False 7010536.854154282 4198711.570952973 8431586.409162775 1.0 0.5989144138747254 1.2027019591468822 22.741093496751194 -6.727636778177091 1.7320777323515195 0.7579937174064865 1.2021758071024162 0.5481948784439026 0.1686400971433923 0.34067520271807833 2.001239725533035 0.0771951343079364 0.19205224384132188 1.8722473382276637e-07 6.727636778177091 0.44418208969592976 DVK(ub)PSNILVNSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVKPSNILVNSR 12 1 Q02750;Q02750-2;P36507;G5E9C7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 1 20052200.0 6231500.0 8265600.0 5555100.0 True False 5181768.352257334 8221071.572206847 6716645.726119629 1.0 1.5865378406245239 1.2962072538795866 22.30501309149608 -10.07405713188894 4.550772976494954 0.9999738323123714 1.4413725472688168 0.7549927245259769 0.11852696577456337 18491834.366443735 20467710.49761281 4050.5960276556984 0.040574934813209354 8.432238235002765e-11 10.07405713188894 0.44139871495644545 DVK(ub)PSNILVNSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVKPSNILVNSR 12 1 Q02750;Q02750-2;P36507;G5E9C7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 1 53839300.0 15011600.0 15875700.0 22952000.0 True False 19432812.122874644 14992203.339138122 18774971.507407468 1.0 0.7714891310810639 0.9661479454796549 24.211991352688297 -10.127607528490378 6.3375598942958025 1.0000003881797843 0.8688185383639148 0.37715263680128097 0.07946912820194894 4.3587366129935504e-07 6.006517826507614e-08 0.07694587953680047 0.0256485508386473 7.454052916739257e-11 10.127607528490378 -0.13118184981586956 DVKPDEDMSGK(ub)NIAMYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVKPDEDMSGKNIAMYR 17 2 Q5T5P2-3;Q5T5P2;Q5T5P2-4;Q5T5P2-8;Q5T5P2-6;Q5T5P2-9;Q5T5P2-2;Q5T5P2-7;Q5T5P2-10;Q5T5P0;Q5T5P1 Q5T5P2-3 KIAA1217 Sickle tail protein homolog 1 12647100.0 1698600.0 3874300.0 7074200.0 True False 2226881.0492658 3296269.541903121 6342229.64451804 1.0 1.4802180578930775 2.8480325191186413 21.0865930667325 -6.952611660402836 0.52940498697706 0.9783349046280434 3.4119449116404783 0.999390570811781 0.01932778126936331 0.08245384102092755 0.031752224519144834 0.021581984393314 0.11310212541641289 1.1152913646222213e-07 6.952611660402836 2.433610007012435 DVKPDEDMSGK(ub)NIAMYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVKPDEDMSGKNIAMYR 17 2 Q5T5P2-3;Q5T5P2;Q5T5P2-4;Q5T5P2-8;Q5T5P2-6;Q5T5P2-9;Q5T5P2-2;Q5T5P2-7;Q5T5P2-10;Q5T5P0;Q5T5P1 Q5T5P2-3 KIAA1217 Sickle tail protein homolog 1 18227800.0 2558600.0 3239200.0 12430000.0 True False 2477378.643506831 4532629.452204841 9174210.107993113 1.0 1.8296070582850905 3.703192538628912 21.240382956827144 -6.957600772114652 0.4680219347600445 0.9495502293081888 4.659801990368904 0.9996706076489474 0.020520799495685284 0.08056955615619488 0.02438426686176621 0.025810129185152242 0.15466032097671495 1.102552371917064e-07 6.957600772114652 3.7102517610607153 DVKPDEDMSGK(ub)NIAMYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVKPDEDMSGKNIAMYR 17 2 Q5T5P2-3;Q5T5P2;Q5T5P2-4;Q5T5P2-8;Q5T5P2-6;Q5T5P2-9;Q5T5P2-2;Q5T5P2-7;Q5T5P2-10;Q5T5P0;Q5T5P1 Q5T5P2-3 KIAA1217 Sickle tail protein homolog 1 14610900.0 2558600.0 5874400.0 6177900.0 True False 2127589.2651986876 5842753.44122289 7469670.326617797 1.0 2.7461848660329924 3.5108610711664934 21.02078823226142 -9.273041798069103 0.2678192601042817 3.4865440894823575e-15 3.934310310959116 0.998951847907563 0.034021014661761856 0.6862661483903767 0.10043380773482728 0.9304169920990163 0.3031683275991017 5.332835678815125e-10 9.273041798069103 3.9343103109591127 DVKPDEDMSGK(ub)NIAMYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVKPDEDMSGKNIAMYR 17 2 Q5T5P2-3;Q5T5P2;Q5T5P2-4;Q5T5P2-8;Q5T5P2-6;Q5T5P2-9;Q5T5P2-2;Q5T5P2-7;Q5T5P2-10;Q5T5P0;Q5T5P1 Q5T5P2-3 KIAA1217 Sickle tail protein homolog 1 71985000.0 7340100.0 6301900.0 58343000.0 True False 9501904.145001993 5951193.725184682 47725172.64973305 1.0 0.6263159083029703 5.02269565356924 23.179785222270805 -6.8862345940488225 1.0443653990105712 0.7420183551542358 5.374112411539926 0.9783780697595498 0.29265434859029726 0.1222529097988608 0.24010214544897968 0.21449383364131955 0.5279950601636206 1.2994674514961023e-07 6.8862345940488225 4.63209405638569 up DVKPDNFLMGLGKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVKPDNFLMGLGKK 14 2 B0QY36;B0QY35;B0QY34;H7BYT1;P48730-2;P48730;P49674;J3QQI9;H0Y645;A0A669KBC0;H0Y2N6 B0QY36 CSNK1E;CSNK1D Casein kinase I isoform delta;Casein kinase I isoform epsilon 1 9201900.0 3338500.0 2640200.0 3223200.0 True False 4376805.830079985 2246292.451418994 2889694.183117606 1.0 0.5132264346709535 0.6602290106766737 22.061446951885937 -10.787850070283358 10.58650559399113 1.0023459019469005 0.5867277226738207 0.9133304488321505 0.06001355034811936 0.003330846248625541 6.674886875817596e-05 0.05824726832483763 0.019369290087087213 1.6298586049804014e-11 10.787850070283358 -0.41561817927307987 DVKPDNFLMGLGKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVKPDNFLMGLGKK 14 2 B0QY36;B0QY35;B0QY34;H7BYT1;P48730-2;P48730;P49674;J3QQI9;H0Y645;A0A669KBC0;H0Y2N6 B0QY36 CSNK1E;CSNK1D Casein kinase I isoform delta;Casein kinase I isoform epsilon 1 13728700.0 4063400.0 4333600.0 5331700.0 True False 3934409.5911927037 6064029.079425451 3935167.822428551 1.0 1.5412805756167243 1.0001927179207637 21.907715726336363 -10.681411219933056 2.7055225327262558 0.9628501405515411 1.2707366454157052 0.25026706609616944 0.2208982016432097 65139493.61906444 56613802.60964766 16638799.661004283 0.08312387886381634 2.0825180776746235e-11 10.681411219933056 0.30788650486416413 DVKPDNFLMGLGKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVKPDNFLMGLGKK 14 2 B0QY36;B0QY35;B0QY34;H7BYT1;P48730-2;P48730;P49674;J3QQI9;H0Y645;A0A669KBC0;H0Y2N6 B0QY36 CSNK1E;CSNK1D Casein kinase I isoform delta;Casein kinase I isoform epsilon 1 19839000.0 4665900.0 6477300.0 8695800.0 True False 7078511.422981606 5321375.207624111 6977071.318495473 1.0 0.7517647270225983 0.9856692885799704 22.755014569677975 -10.545053511648193 8.230161424147857 1.0000236551348587 0.8687170078470491 0.29578855435866536 0.09549113738749655 4.1454984065424525e-05 2.2915531429235665e-06 0.09247553727290923 0.03081963206768156 2.8506670005773162e-11 10.545053511648193 -0.1313066472878096 DVKPDNFLMGLGKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVKPDNFLMGLGKK 14 2 B0QY36;B0QY35;B0QY34;H7BYT1;P48730-2;P48730;P49674;J3QQI9;H0Y645;A0A669KBC0;H0Y2N6 B0QY36 CSNK1E;CSNK1D Casein kinase I isoform delta;Casein kinase I isoform epsilon 1 14034400.0 4063400.0 5810000.0 4161000.0 True False 3378897.1391418525 5778700.3768053 5031045.861709749 1.0 1.7102326998545248 1.4889609403698798 21.68812100177064 -10.144088696271542 4.699765589485497 0.9999431664923166 1.599596820097924 0.907325990410095 0.09033381755806852 5.388229373825992e-05 9.812857194177617e-06 0.08747361152725691 0.02915511424723777 7.176477106003618e-11 10.144088696271542 0.5996536536056074 DVKPDNFLMGLGKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVKPDNFLMGLGKK 14 2 B0QY36;B0QY35;B0QY34;H7BYT1;P48730-2;P48730;P49674;J3QQI9;H0Y645;A0A669KBC0;H0Y2N6 B0QY36 CSNK1E;CSNK1D Casein kinase I isoform delta;Casein kinase I isoform epsilon 1 17591400.0 4665900.0 7719700.0 5205800.0 True False 6040099.5286392355 7290091.908838324 4258397.816018725 1.0 1.2069489706704712 0.7050211334809068 22.526140891770424 -6.794743280847788 1.477260098754027 1.1149573597913833 0.6989589691012842 0.8163261647001141 0.08826822770981328 0.22836471614217277 0.9843335916809778 0.04701840158240389 0.109716924637726 1.604193377564953e-07 6.794743280847788 -0.41599839069009914 DVLDVYIEHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVLDVYIEHR 10 0 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 0 16827400.0 5065500.0 6783100.0 4978800.0 False True 6640919.554371787 5771087.920316711 4463641.53602194 1.0 0.8690193990555937 0.6721420880762632 22.662951591721594 -6.965222868260185 0.35420673795107305 1.0181281740306585 0.5163468150141075 0.9999176641590541 0.0012226558539342378 0.07788542220514671 0.014593746728314119 0.002674915909050319 0.01687599277419339 1.0833708145499953e-07 6.965222868260185 -0.501781359016551 DVLDVYIEHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVLDVYIEHR 10 0 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 0 23264900.0 6078100.0 4533800.0 12653000.0 False True 5885154.042483733 6344169.983454654 9338799.718136521 1.0 1.0779955694714833 1.5868403189995743 22.48864874727589 -6.934089503820725 0.712421818484281 0.9933113295800952 1.7030862874215575 0.9972827776477214 0.01356401277302681 0.09056912247713615 0.06767983106544762 0.012673224779967017 0.0450512501076267 1.1638861392072649e-07 6.934089503820725 0.7097749578414624 DVLDVYIEHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVLDVYIEHR 10 0 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 0 70985000.0 11103000.0 36953000.0 22929000.0 False True 16844062.738027975 30358448.43489318 18397073.09986227 1.0 1.8023234006576376 1.0921992743667561 24.00573681835726 -10.170969376531772 4.328151985700999 0.9998928226081146 1.4472613375314554 0.34594506665253844 0.28990696068804606 42682592.73222467 50151180.09135653 38055.70415302092 0.0992428640271445 6.74575592465093e-11 10.170969376531772 0.44736851492334073 DVLDVYIEHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVLDVYIEHR 10 0 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 0 16233500.0 5065500.0 6890500.0 4277500.0 False True 6938352.239990335 6586054.926163599 3267242.5978778047 1.0 0.9492246427334414 0.4708960405680349 22.726161653244485 -6.927188646292372 0.769517858005835 1.0080824140364946 0.3793764952916749 0.9959562941017793 0.01515716654031037 0.09412408734594294 0.08502564603038362 0.013584634455443436 0.04396851136414297 1.1825277846585381e-07 6.927188646292372 -0.6287059187448196 down DVLDVYIEHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVLDVYIEHR 10 0 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 0 14163700.0 6078100.0 4297400.0 3788200.0 False True 5054209.455485091 4274249.053232881 4580295.105342193 1.0 0.8456810290270508 0.9062337336200854 22.269054022710165 -10.891078111745863 10.01398698316566 1.0100653424406614 0.8759573813235682 0.8483739412103539 0.024720538133069694 0.005700691680320551 6.200618098118684e-05 0.02456267125673223 0.007978519374888684 1.2850555104330675e-11 10.891078111745863 -0.13410796111709322 DVLDVYIEHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVLDVYIEHR 10 0 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 0 46345000.0 11103000.0 22420000.0 12822000.0 False True 14373052.372850126 21172307.29123605 10488527.564830033 1.0 1.4730557394495638 0.7297355699226604 23.77686314044971 -6.734730482963042 1.7056835631017517 1.2831617836142861 0.7297539984328005 0.5812247998360263 0.1987981929847519 0.327418786086291 1.8681659182271886 0.09227784265114505 0.22779130312118226 1.841914713178269e-07 6.734730482963042 -0.5534077851814856 DVLGAAK(ub)TGSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVLGAAKTGSGK 12 1 Q13206;E9PIF2;A0A3B3ISR7 Q13206 DDX10 Probable ATP-dependent RNA helicase DDX10 1 11156500.0 1480400.0 1537600.0 8138500.0 True False 2245875.0317370617 1263203.2666763684 6529921.907768729 1.0 0.5624548333392129 2.907517923077933 21.09884622274874 -6.858483719667239 1.1933400617670418 0.7634858837278554 3.0178473063997715 0.9517698074367733 0.22359644659024927 0.14837759825688362 0.40236798438535004 0.14622355611871515 0.3407753973273823 1.3852121121919585e-07 6.858483719667239 2.254361422671916 up DVLGAAK(ub)TGSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVLGAAKTGSGK 12 1 Q13206;E9PIF2;A0A3B3ISR7 Q13206 DDX10 Probable ATP-dependent RNA helicase DDX10 1 3024030.0 645230.0 1163200.0 1215600.0 True False 536537.3335355852 1156933.6107228778 1469776.33970064 1.0 2.1562965676574777 2.7393738475109464 19.033319035041572 -9.29445845051704 0.20845440805993143 6.69142937090936e-13 3.2804473073904195 0.9994513828830809 0.016930672482651246 0.7242160433679105 0.07778478532697945 0.789797621311621 0.3134690350508311 5.076233016464551e-10 9.29445845051704 3.28044730738975 DVLGAAK(ub)TGSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVLGAAKTGSGK 12 1 Q13206;E9PIF2;A0A3B3ISR7 Q13206 DDX10 Probable ATP-dependent RNA helicase DDX10 1 16472100.0 1480400.0 1807700.0 13184000.0 True False 1916406.9830466819 1707099.9059039878 10784647.279263688 1.0 0.8907815098805683 5.62753495195388 20.86997254484119 -6.901624689599095 0.950958713887054 0.8117460692482965 6.141439017580668 0.9873568917489732 0.24822987867693352 0.1102186161080935 0.1707599182912396 0.19516413221573106 0.5120395677917189 1.2542245877295707e-07 6.901624689599095 5.329692948332371 up DVLK(ub)LVEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVLKLVEAR 9 1 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 1 5239700.0 1943300.0 1949200.0 1347200.0 True False 2547685.11894397 1658386.957922092 1207804.667254913 1.0 0.6509387465471018 0.4740792566059163 21.28075554809184 -13.9996487379076 0.08761620100045812 2.806672674323829 0.013014769166545504 0.9998534645084203 0.0026450855148254415 12.18392680812467 0.0854071575612365 4.134836711419487 0.4151732307043664 1.0008091380333967e-14 13.9996487379076 -2.7936579051572834 DVLK(ub)LVEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVLKLVEAR 9 1 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 1 7671300.0 1905400.0 2158900.0 3607000.0 True False 1844914.1199632282 3020960.028514772 2662218.492319481 1.0 1.6374529284728896 1.443004020356537 20.815122230278227 -10.394069632937477 5.282922598825902 0.9996599880026525 1.5402284744147274 0.9114385470947343 0.07938343432111536 0.00031810151835768864 3.648506595375748e-05 0.07690972613138863 0.025620893257528653 4.035806793633043e-11 10.394069632937477 0.5405684864120749 DVLK(ub)LVEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVLKLVEAR 9 1 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 1 24590700.0 4673600.0 7940100.0 11977000.0 True False 7090192.885927006 6523127.118715539 9609740.700294424 1.0 0.9200211085460017 1.355356737807282 22.7573934452777 -6.859288916200649 1.1893031102314215 0.9566849471140535 1.3761550811719359 0.952769912314185 0.041119288445733884 0.1475394594010181 0.39694469489746165 0.026973565597130773 0.06291565827672221 1.3826462618045274e-07 6.859288916200649 0.41947013405788236 DVLK(ub)LVEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVLKLVEAR 9 1 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 1 6323300.0 1943300.0 2293400.0 2086600.0 True False 2661790.5257078675 2192070.0047403816 1593788.0548759406 1.0 0.8235321237975441 0.5987653947532532 21.34396560961473 -6.967832455756932 0.3055615657239057 1.0364931832060105 0.37870528713789664 0.9999601936924513 0.001035948764823021 0.07701254011982699 0.011534690115023257 0.0036299159203681554 0.020042745194226184 1.0768805777447822e-07 6.967832455756932 -0.6577878960681138 DVLK(ub)LVEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVLKLVEAR 9 1 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 1 8269100.0 1905400.0 3605600.0 2758100.0 True False 1584424.5235322362 3586175.9171444387 3334805.9579864563 1.0 2.2633933417980674 2.1047427052896204 20.595527505712504 -10.55500974002218 6.371012403497369 0.9982688361001648 2.184068023543844 0.9867143428793571 0.06476885113557723 0.0015939248013155992 0.00011132912526254746 0.06276318940298328 0.020904056816756472 2.78605868435053e-11 10.55500974002218 1.1857991874436793 DVLK(ub)LVEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVLKLVEAR 9 1 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 1 24201300.0 4673600.0 7527700.0 12000000.0 True False 6050067.3304289235 7108776.8776198905 9816123.130397785 1.0 1.17499136610698 1.6224816343823838 22.52851976737015 -6.954974867065926 0.501262743766566 0.9911354207308279 1.8256797078939278 0.9995360677965639 0.00564578038289853 0.0815474717720666 0.02815503281809698 0.006605426397375672 0.03691556856728464 1.1092390058641973e-07 6.954974867065926 0.8345442871630998 DVLLAHCMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVLLAHCMK 9 0 Q155Q3-2;Q155Q3 Q155Q3-2 DIXDC1 Dixin 0 10118900.0 2765900.0 2898200.0 4454800.0 False True 3626121.685013706 2465799.857095116 3993860.0294590206 1.0 0.6800102344292386 1.101413680066262 21.789995909028466 -6.7037052243589015 1.8178539998330834 0.8020190911284126 1.1002415138320363 0.43504271358630764 0.1349831118268989 0.38788855878460365 2.49455974937235 0.05918409833076355 0.15150244300311766 1.978311955835399e-07 6.7037052243589015 0.29822242270362365 DVLLAHCMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVLLAHCMK 9 0 Q155Q3-2;Q155Q3 Q155Q3-2 DIXDC1 Dixin 0 9552400.0 2765900.0 3295300.0 3491200.0 False True 3788527.975637009 3149702.7499001347 2666650.463520984 1.0 0.831379039604568 0.7038750883376041 21.853205970551357 -6.974216792000651 0.12049978744491953 1.2276803313159352 0.3042965339769196 0.9999994355153996 9.093747072111229e-05 0.07495656687566514 0.0035897603327001565 0.008929761313383938 0.018326365797523475 1.061165710112398e-07 6.974216792000651 -0.9233837973390157 DVLLPWYNAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVLLPWYNAYR 11 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 4549800.0 1076700.0 1472300.0 2000800.0 False True 1411564.1267776312 1252638.5789804517 1793776.409028822 1.0 0.8874117407899984 1.2707721703892536 20.42886324064283 -6.828063715132615 1.3364526285349485 0.9397533396954465 1.280692039257274 0.90195812483759 0.05037606072751317 0.18321638784037986 0.6406688258421307 0.02960072177458331 0.06813022456788717 1.4857176573808853e-07 6.828063715132615 0.34093869956182754 DVLLPWYNAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVLLPWYNAYR 11 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 5542400.0 1076700.0 1797600.0 2668100.0 False True 1474785.0867234392 1718176.0881317302 2037949.7312443648 1.0 1.1650348946428783 1.381862177473004 20.49207330216572 -6.967365858381379 0.3148157782917805 0.9684398791382995 1.5853978928884855 0.9999539354601281 0.0010612933148390479 0.07716706467499194 0.012075343471407414 0.003358582077019801 0.01916241998227244 1.0780381786140382e-07 6.967365858381379 0.616958013750186 DVLLQVDDERR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVLLQVDDERR 11 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 26367500.0 5591400.0 9942000.0 10834100.0 False True 7330379.547194629 8458692.35361248 9713091.260025581 1.0 1.1539228356667646 1.325046158591178 22.805456468458072 -6.969757833904261 0.2639135623017314 0.9541954177427672 1.5298766143994813 0.9999804273738578 0.0005873210581808295 0.07638143802897211 0.009311309691824947 0.0034839572508262666 0.016052840402350204 1.0721169596324114e-07 6.969757833904261 0.5756811966567141 DVLLQVDDERR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVLLQVDDERR 11 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 17347100.0 4917800.0 2135300.0 10294000.0 False True 4761687.130867624 2987936.425442396 7597692.58661956 1.0 0.6274953274592752 1.595588365595786 22.183041400017615 -6.802390029413892 1.4460220540000759 0.7950839681191048 1.6097685899372098 0.8390622561116625 0.15994857437457186 0.21738099885237971 0.8970892945845299 0.08700574720573968 0.20206621667344066 1.576195091029133e-07 6.802390029413892 0.8146846218181051 DVLLQVDDERR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVLLQVDDERR 11 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 41645900.0 2889700.0 37376100.0 1380100.0 False True 4383886.165367871 30706042.93419782 1107322.6300806825 1.0 7.004297505891362 0.2525892754306412 22.06377890621945 -6.672076965521212 1.9298200646873758 4.825555276821948 0.27943753579958264 0.2884241639259211 2.5492597525396654 0.4563206459250467 3.2782443495090963 1.062672160241593 2.8317231725944843 2.1277619313177367e-07 6.672076965521212 -4.546117741022366 DVLLQVDDERR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVLLQVDDERR 11 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 27131300.0 5591400.0 10977200.0 10562700.0 False True 7658691.681903453 10492191.007253896 8068007.805635044 1.0 1.3699717188048781 1.0534446535690627 22.868666529980963 -10.32358081346762 5.897762783703067 0.9999783040961978 1.211708186186971 0.3736200552850536 0.12922163326806702 3.686776825775583e-05 4.2283555327347055e-06 0.1251311203202784 0.0417061028014119 4.7469995061004786e-11 10.32358081346762 0.21172988209077315 DVLLQVDDERR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVLLQVDDERR 11 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 9341510.0 4917800.0 1954500.0 2469210.0 False True 4089368.5954796043 1943970.7205621249 2985510.3946628985 1.0 0.475371851466506 0.7300663476418064 21.96344667545189 -10.142125252847695 5.071419558376056 1.0000177196264812 0.6027190995535198 0.7643790977863121 0.10397859265634167 2.0832838825877637e-05 3.52406213563043e-06 0.10068132598103201 0.0335589464763563 7.208995379223465e-11 10.142125252847695 -0.39729862007296146 DVLSVAFSSDNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVLSVAFSSDNR 12 0 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RFZ9;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 75427000.0 19859000.0 29684000.0 25884000.0 False True 26035341.31482956 25255262.90732572 23205771.976860266 1.0 0.9700377115064163 0.8913181393033018 24.633967984324922 -6.954389095520585 0.5083848485694153 1.0014682295048851 0.8564435916579568 0.9995021939787151 0.001022597375791582 0.08176979124742617 0.029028434842310668 0.0011811427443120753 0.006496240440647709 1.1107361444780603e-07 6.954389095520585 -0.14502463784692832 DVLSVAFSSDNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVLSVAFSSDNR 12 0 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RFZ9;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 116441500.0 33665000.0 28292500.0 54484000.0 False True 32596323.00228937 39589842.79343842 40213005.91503593 1.0 1.2145493462762 1.2336669357525882 24.958205895982246 -12.738030391571938 0.36080750913853876 2.942007118013981e-11 1.2360453918779783 0.9997182909543975 0.0017779985097621483 8.867006639562259 0.19144420663303457 6.62512821631388 0.005502291449899725 1.8279722916638288e-13 12.738030391571938 1.2360453918485583 DVLSVAFSSDNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVLSVAFSSDNR 12 0 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RFZ9;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 254874900.0 50728900.0 121950000.0 82196000.0 False True 76959450.07936116 100187069.70030117 65949924.572213314 1.0 1.3018163409040413 0.856943812672846 26.19759515444978 -6.724007556686731 1.7450234426055873 1.1828306204857457 0.8574813426308238 0.5313297839036868 0.12694673031881862 0.34757399901129216 2.0705450436124555 0.05771750318776287 0.14420701484958245 1.8879584984945731e-07 6.724007556686731 -0.32534927785492196 DVLSVAFSSDNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVLSVAFSSDNR 12 0 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RFZ9;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 86077000.0 19859000.0 23306000.0 42912000.0 False True 27201408.9692958 22276263.857364316 32777069.400381595 1.0 0.8189378676122677 1.204976897975375 24.697178045847814 -6.779169862233902 1.539211544269855 0.8973688188888229 1.207950527766951 0.7644238003730095 0.07654184022418975 0.25185647000477807 1.1785432526895208 0.03917009563889087 0.09248520741530718 1.6627621798906266e-07 6.779169862233902 0.3105817088781282 DVLSVAFSSDNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVLSVAFSSDNR 12 0 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RFZ9;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 57125000.0 33665000.0 1529000.0 21931000.0 False True 27993939.112371583 1520762.9735172607 26516670.702512942 1.0 0.0543247224841315 0.9472289911066578 24.738611171416522 -9.472174131646952 12.608869871083309 1.0000190778365603 0.5007768567953946 0.29417960518447495 0.36452664137944163 0.0 0.0 0.3529514027526835 0.1176504675842278 3.371520994307757e-10 9.472174131646952 -0.49924222104116567 DVLSVAFSSDNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVLSVAFSSDNR 12 0 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RFZ9;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 223988900.0 50728900.0 103540000.0 69720000.0 False True 65669561.06611514 97777907.98102514 57031675.38761105 1.0 1.4889380466938678 0.8684643914429762 25.96872147654223 -6.696582829663469 1.8428369609303044 1.304614939938214 0.8704093680557848 0.4015028618994103 0.2065176591942711 0.40265941627679763 2.6560089824571493 0.0894812846537804 0.231116656955023 2.0110236144767137e-07 6.696582829663469 -0.43420557188242925 DVMAK(ub)TESPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVMAKTESPR 10 1 O14733;O14733-4;O14733-3;O14733-2 O14733 MAP2K7 Dual specificity mitogen-activated protein kinase kinase 7 1 7627000.0 0.0 2255700.0 5371300.0 True False 0.0 2130168.312080341 4393778.514192126 0.0 DVNAAIAAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVNAAIAAIK 10 0 P68366-2;P68366 P68366-2 TUBA4A Tubulin alpha-4A chain 0 3072800.0 1052100.0 2020700.0 0.0 False True 1379313.2885508945 1719219.4366269063 0.0 1.0 1.2464314314212959 0.0 20.395518748079567 -6.899414564982124 1.2996627380932098 1.128378104386616 1.584239353705536e-23 0.9463964266320267 0.12478286962783666 0.13491954017698823 0.45742595542380143 0.07839715632231374 0.15635829391103462 1.2606236051420802e-07 6.899414564982124 -1.128378104386616 down DVNAAIAAIKTK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVNAAIAAIKTK 12 1 P68366-2;P68366 P68366-2 TUBA4A Tubulin alpha-4A chain 1 12740900.0 3512600.0 7249000.0 1979300.0 True False 2920882.534564575 7209948.19818616 2393162.4787508016 1.0 2.468414293579584 0.81932855923888 21.477972909617684 -6.671781155451176 1.9306095781488428 1.935799793836458 0.8258667760944782 0.2872118768000207 0.623487086332154 0.4570050930761315 3.285493859942838 0.2598077714038512 0.6926465633733249 2.1292117029274124e-07 6.671781155451176 -1.1099330177419797 DVNAAIAAIKTK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVNAAIAAIKTK 12 1 P68366-2;P68366 P68366-2 TUBA4A Tubulin alpha-4A chain 1 16607800.0 6623100.0 2560200.0 7424500.0 True False 8573733.510819038 2417722.6194033246 6073317.181803186 1.0 0.28199180862718026 0.7083631855526391 23.031492145262042 -10.659023543765874 5.932996617296456 1.0047876957542343 0.4951774970917102 0.6514625803644961 0.174065385732542 0.011080423359437198 0.0006368043791388812 0.16941020181943836 0.05617936167444208 2.1926860632744803e-11 10.659023543765874 -0.5096101986625241 DVNAAIATIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVNAAIATIK 10 0 P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 105074300.0 37517000.0 63826000.0 3731300.0 False True 49185150.31514482 54303409.591799416 3345220.869156958 1.0 1.1040610681040983 0.06801282191318049 25.551719475702654 -6.890238033665912 1.0803514949528032 1.0658171773097307 1.4950566464621909e-18 0.9753865111497428 0.07307973614847577 0.12271721281801413 0.2635701079509577 0.05246582949724629 0.12411721273892126 1.2875436648903145e-07 6.890238033665912 -1.0658171773097307 down DVNAAIATIK(ub)TK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVNAAIATIKTK 12 1 P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 637690000.0 204600000.0 264050000.0 169040000.0 True False 268232581.3492183 224654769.25883853 151549362.3461776 1.0 0.8375372153853122 0.5649923718583312 27.998909246513012 -6.963331370611143 0.3856207983432786 1.0175774394193626 0.3752276866637671 0.9998745062170167 0.0020105599416014347 0.07853185306202677 0.016885486978204106 0.0035290893491665113 0.022969831578726802 1.0880995467373245e-07 6.963331370611143 -0.6423497527555955 DVNAAIATIK(ub)TK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVNAAIATIKTK 12 1 P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 641850000.0 132500000.0 269030000.0 240320000.0 True False 128293860.02683318 376455081.9729162 177372982.55453792 1.0 2.9343187732770617 1.3825523880678283 26.93487688571664 -6.591305448449918 2.224060977601947 2.308147750162476 1.3871621865973665 0.0 0.8379361769715872 0.665806470221531 6.210893603332878 0.3143010074045381 0.9335979869461617 2.5626810150447583e-07 6.591305448449918 -0.9209855635651096 DVNAAIATIK(ub)TK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVNAAIATIKTK 12 1 P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 530290000.0 204600000.0 186180000.0 139510000.0 True False 280246149.107101 177953951.9850718 106560611.29864004 1.0 0.6349916048875431 0.38023934187197705 28.062119308035903 -8.05965701112462 0.18154682264771682 1.2921435469924045 1.3209309257279725e-13 0.9998819079967679 0.0027639901755453864 0.09678604752637986 0.032982846598761995 0.09076362732507011 0.11025062530686999 8.71651714785466e-09 8.05965701112462 -1.2921435469922724 down DVNAAIATIK(ub)TK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVNAAIATIKTK 12 1 P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 529180000.0 132500000.0 287820000.0 108860000.0 True False 110179620.74526161 286269456.53220296 131622122.68822938 1.0 2.598206951483941 1.1946140474792832 26.715282161150917 -6.614849769254555 2.1361921095538934 2.064261361436732 1.1998479910198458 0.06570620568728236 0.6881898489080607 0.5992773030952113 5.189271273422543 0.26541336994170506 0.763317636111079 2.4274496510026554e-07 6.614849769254555 -0.8644133704168859 DVNAAIATIK(ub)TK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVNAAIATIKTKR 13 2 P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 2 82211600.0 21147100.0 39139600.0 21924900.0 True False 27724052.888807718 33300124.244965844 19656321.666491434 1.0 1.2011275688486802 0.70899885183911 24.724634839983214 -6.7957391296616025 1.4732026245714924 1.111578768748577 0.7028962677697567 0.81941160470263 0.08585165971181158 0.22690477528891784 0.9726063763482368 0.04585456415481471 0.10693148468951527 1.6005191336043604e-07 6.7957391296616025 -0.4086825009788203 DVNAAIATIK(ub)TK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVNAAIATIKTKR 13 2 P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 2 74165800.0 20993200.0 24538500.0 28634100.0 True False 20326782.357096683 34336851.016587034 21133970.20541316 1.0 1.6892418294919669 1.0397105569458052 24.276878524999145 -10.195660166240268 4.7125827413168535 0.9999409604806493 1.3644761932208225 0.2956919926322702 0.2651700316264781 0.00016451519252266137 2.8079311578535955e-05 0.25679126111913153 0.08558325969927262 6.372940059567695e-11 10.195660166240268 0.3645352327401732 DVNAAIATIK(ub)TK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVNAAIATIKTKR 13 2 P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 2 91696700.0 21147100.0 38922600.0 31627000.0 True False 28965754.348889444 37202870.83217406 24157353.978511125 1.0 1.2843743126475984 0.8339970603747568 24.787844901506105 -6.736033011703564 1.7012060981113033 1.169966496070022 0.8339510331178979 0.587115403855581 0.1194974136129259 0.32498824036378726 1.8451673293786497 0.05560542060669571 0.13705016040796236 1.8363987492301796e-07 6.736033011703564 -0.33601546295212414 DVNAAIATIK(ub)TK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVNAAIATIKTKR 13 2 P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 2 65468900.0 20993200.0 30199800.0 14275900.0 True False 17456775.956448473 30037107.683209054 17260924.685696248 1.0 1.7206560798022643 0.9887807879736304 24.05728380043342 -10.165477692435358 3.862841959971235 0.999793568786855 1.3547184335725646 0.2385056867624351 0.2987868373642243 210984596.10044387 357985347.1008943 542904.4100662806 0.10934477009519146 6.831598076265688e-11 10.165477692435358 0.3549248647857096 DVNAAIATIK(ub)TK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVNAAIATIKTKR 13 2 P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 2 59240300.0 24553800.0 17507800.0 17178700.0 True False 31785378.12775716 16533475.539406918 14052352.868347034 1.0 0.5201597877159988 0.4421011702885976 24.92185991544898 -13.999999999999998 0.25556303429558125 4.432901032905619 0.4123350761164465 0.9995534187405903 0.005212629167426959 14.225432256056465 0.15996543360218238 25.153138626003816 0.03494267332812923 1.0000000000000041e-14 13.999999999999998 -4.020565956789173 DVNPGGK(ub)EETPGQRPAVTETHQLAELNEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVNPGGKEETPGQRPAVTETHQLAELNEK 29 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L1I8;I3L182;Q9UQ35-3;I3L1C0;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 72499700.0 23211000.0 24170500.0 25118200.0 True False 30429845.77564377 20564355.61587106 22519209.614787996 1.0 0.675795591193265 0.7400369289026271 24.858983686224487 -10.767821728828233 7.004652499960081 1.0069052476615692 0.7079162600480823 0.9649895039723531 0.02622641629695874 0.0028596155226322862 9.478550155000893e-05 0.025675892284162245 0.008464539462402002 1.7067828532072764e-11 10.767821728828233 -0.2989889876134869 DVNPGGK(ub)EETPGQRPAVTETHQLAELNEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVNPGGKEETPGQRPAVTETHQLAELNEK 29 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L1I8;I3L182;Q9UQ35-3;I3L1C0;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 72394900.0 21540400.0 18610500.0 32244000.0 True False 20856611.792618845 26041769.702475373 23798329.10073452 1.0 1.2486097915334242 1.1410448320832605 24.31400147178107 -10.22819946868476 4.7236786051636415 0.9999559566390991 1.1948273118089334 0.8139251427486065 0.04391321081171752 2.037452754914415e-05 3.329094447955309e-06 0.04252838657258439 0.014172927845686764 5.912899960766299e-11 10.22819946868476 0.19487135516983434 DVNPGGK(ub)EETPGQRPAVTETHQLAELNEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVNPGGKEETPGQRPAVTETHQLAELNEK 29 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L1I8;I3L182;Q9UQ35-3;I3L1C0;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 123616400.0 29226400.0 45880000.0 48510000.0 True False 44338585.536044374 37692355.53792381 38921977.23731167 1.0 0.8501027960687286 0.8778353383797199 25.402059411126643 -10.025666300342474 5.061017634564414 1.0000015941076237 0.8639690672233296 0.9697702706318987 0.011321762991788043 2.0364541194736408e-07 3.92164620391287e-08 0.010962378268646551 0.0036540832926295424 9.42613596095998e-11 10.025666300342474 -0.13603252688429412 DVNPGGK(ub)EETPGQRPAVTETHQLAELNEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVNPGGKEETPGQRPAVTETHQLAELNEK 29 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L1I8;I3L182;Q9UQ35-3;I3L1C0;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 65818200.0 23211000.0 17746400.0 24860800.0 True False 31792733.95368979 16962305.368502945 18989191.06424793 1.0 0.5335277360295823 0.5972808469981893 24.92219374774738 -10.434810460559051 6.007002443831209 1.0001749808366858 0.5654042915140213 0.9841167343887615 0.02602709856468718 6.101662697839195e-05 5.7408860030176425e-06 0.02521062763504005 0.008400209940927645 3.674426287499199e-11 10.434810460559051 -0.4347706893226645 DVNPGGK(ub)EETPGQRPAVTETHQLAELNEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVNPGGKEETPGQRPAVTETHQLAELNEK 29 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L1I8;I3L182;Q9UQ35-3;I3L1C0;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 70600900.0 21540400.0 31014000.0 18046500.0 True False 17911797.001518738 30846921.426203024 21819939.712411657 1.0 1.722156711779813 1.218188198010593 24.094406747215345 -10.626679976979334 5.756479350950616 0.9966638299661643 1.4701724548952027 0.5371448368101415 0.20574428419389806 0.008854308119648008 0.0005742199549017858 0.20023194217497262 0.06640368218836105 2.3622182639584154e-11 10.626679976979334 0.47350862492903834 DVNPGGK(ub)EETPGQRPAVTETHQLAELNEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVNPGGKEETPGQRPAVTETHQLAELNEK 29 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L1I8;I3L182;Q9UQ35-3;I3L1C0;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 149242400.0 29226400.0 68347000.0 51669000.0 True False 37834150.93847309 64543429.36815846 42265772.16871022 1.0 1.7059568608562332 1.1171328315902727 25.173185733219093 -10.31035677542134 4.034457648115169 0.9993217556579209 1.4115448462361744 0.3944280383682234 0.2403864034130429 32439778.40118703 41452596.900306866 160002.38794626473 0.08229065742510137 4.8937662846760665e-11 10.31035677542134 0.41222309057825346 DVNQQEFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVNQQEFVR 9 0 P39019;M0R2L9;M0QYF7;M0R140 P39019 RPS19 40S ribosomal protein S19 0 21807300.0 5357900.0 1365400.0 15084000.0 False True 5187816.397266179 1910611.340466938 11133047.889699763 1.0 0.36828815712787594 2.145998824392964 22.306695991195827 -6.810633196147893 1.4117215775490173 0.6559636331057264 2.1775902634430024 0.8614845234575714 0.27384797912582626 0.20595597097491364 0.8088416135576156 0.15251658009782734 0.3527264841723399 1.546560108233233e-07 6.810633196147893 1.521626630337276 up DVNVNFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVNVNFEK 8 0 Q15185-4;Q15185;A0A087WYT3;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 20237800.0 7469700.0 2945100.0 9823000.0 False True 7232578.462207056 4121093.788493613 7250061.616316674 1.0 0.5697959323950481 1.0024172781810767 22.78607863855724 -10.951974399168453 10.909062098369919 1.0640152006760306 0.7861066052880982 0.24580949525082774 0.17661692483532193 0.0999330382373837 0.0004399406251103501 0.06214731844579241 0.0570028673787974 1.1169290866797784e-11 10.951974399168453 -0.27790859538793244 DVNVNFEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVNVNFEK 8 0 Q15185-4;Q15185;A0A087WYT3;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 26707900.0 6277000.0 8062900.0 12368000.0 False True 8597776.529546805 7706654.4175552465 9446933.126955636 1.0 0.8963543529040141 1.098764674156237 23.035532182098933 -6.767489628845629 1.5838641555150752 0.9403626469015521 1.099802356608592 0.7209627947444626 0.043654615667342106 0.27049571197060124 1.3387621977944548 0.02172935305294114 0.05184910574500493 1.7080885095213099e-07 6.767489628845629 0.1594397097070398 DVNVNFEK(ub)SK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVNVNFEKSK 10 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 83195000.0 32246000.0 29998000.0 20951000.0 True False 42274818.27070819 25522415.33128818 18783191.496182963 1.0 0.6037261986049132 0.444311584638973 25.333295217060595 -13.999999999963494 0.1254906400229033 2.8836491486111044 0.20772903385605684 0.9996664818031613 0.004266610653569967 11.946045260682652 0.10969141621976454 5.575046138700779 0.21011274276867073 1.000000000084058e-14 13.999999999963494 -2.6759201147550478 DVNVNFEK(ub)SK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVNVNFEKSK 10 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 90334000.0 31879000.0 24716000.0 33739000.0 True False 30867018.59468233 34585227.69223726 24901743.751695845 1.0 1.1204589645141656 0.8067427592759424 24.87956280584982 -6.802603106830425 1.445114785683383 1.0662448282497523 0.8021211980210841 0.8397059205332853 0.05173484309362072 0.21706104333445392 0.8946136409455446 0.028159198736056 0.06539116873890158 1.5754219538695092e-07 6.802603106830425 -0.26412363022866825 DVNVNFEK(ub)SK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVNVNFEKSK 10 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 163797000.0 38543000.0 39841000.0 85413000.0 True False 58472548.87073878 32731062.270846203 68531083.11215222 1.0 0.5597680091422472 1.1720214773542563 25.801256145267274 -6.71372593890651 1.7817301300099357 0.730393931601221 1.170759019751545 0.4828546400657181 0.18540710812151137 0.3676415888236095 2.277240320979939 0.08273627055728043 0.20926001925458804 1.9331878684269458e-07 6.71372593890651 0.44036508815032394 DVNVNFEK(ub)SK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVNVNFEKSK 10 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 77160000.0 32246000.0 24600000.0 20314000.0 True False 44168217.61538407 23513090.658678535 15516251.579962533 1.0 0.5323531699519787 0.35129902037428207 25.396505278583486 -13.999999999999998 0.13132540398758216 3.222908175456748 0.10196194906351443 0.999639657796901 0.0051881609177636895 11.934903970146724 0.11282309108971585 6.840125781173167 0.22185794990024732 1.0000000000000041e-14 13.999999999999998 -3.1209462263932335 DVNVNFEK(ub)SK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVNVNFEKSK 10 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 94681000.0 31879000.0 43836000.0 18966000.0 True False 26508800.979156148 43599846.76723529 22931702.911123995 1.0 1.6447310009048624 0.8650599824999696 24.659968081284095 -6.687104345805983 1.8767971201215472 1.4052958058926668 0.8678500959914212 0.35690053120578513 0.27283779414115644 0.4229027463946475 2.8858142276113994 0.11639923477569084 0.304212406680425 2.0553966965656831e-07 6.687104345805983 -0.5374457099012456 DVNVNFEK(ub)SK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVNVNFEKSK 10 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 147375000.0 38543000.0 35503000.0 73329000.0 True False 49894673.29611482 33527226.840354826 59983874.41907823 1.0 0.6719600435376638 1.2022099846828547 25.572382467359724 -6.739401709922175 1.6893277259799322 0.8046781093201446 1.2024536576047002 0.6020774368064884 0.13782961955196132 0.31889351773414193 1.7867741140276445 0.06455672809117809 0.15849357961803984 1.8222094311764118e-07 6.739401709922175 0.39777554828455564 DVPIGAIICITVGKPEDIEAFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVPIGAIICITVGKPEDIEAFK 22 1 P10515;E9PEJ4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 106600000.0 24828000.0 40809000.0 40963000.0 False True 37665891.169932306 33526315.107827697 32866645.09527926 1.0 0.8900974878457376 0.8725837641010296 25.16675532791705 -13.999999999766708 0.2584977170987647 1.7982768479456395 0.8660899043851301 0.9995592734197694 0.0011838439526598264 14.351175871704452 0.16088652189229508 5.979009790065431 0.00771781223562331 1.0000000005371758e-14 13.999999999766708 -0.9321869435605094 DVPIGAIICITVGKPEDIEAFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVPIGAIICITVGKPEDIEAFK 22 1 P10515;E9PEJ4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 52907800.0 24828000.0 7486800.0 20593000.0 False True 32140335.43304717 7070152.998573876 16845285.302023433 1.0 0.21997757345445249 0.5241166613557761 24.937881650009498 -10.478990213911521 6.1375945820342634 1.0003982724063745 0.3720471174155661 0.8503873202109667 0.12416426269895407 0.0006770775910844748 5.7475609402566266e-05 0.12029394561840953 0.04007384346893094 3.3190193631473246e-11 10.478990213911521 -0.6283511549908083 DVPLGTPLCIIVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVPLGTPLCIIVEK 14 0 P10515;H0YDD4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 17863800.0 5703800.0 6537600.0 5622400.0 False True 7477737.035677768 5562215.563365212 5040647.981869074 1.0 0.7438367432321806 0.6740873552813025 22.83417030716987 -13.999999999999998 0.18255793005731658 2.339746075763099 0.6201207275488619 0.999495274425924 0.003147954325509463 12.238935288711533 0.13546750312096942 5.819825591507146 0.05096712288106199 1.0000000000000041e-14 13.999999999999998 -1.7196253482142367 DVPLGTPLCIIVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVPLGTPLCIIVEK 14 0 P10515;H0YDD4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 6499100.0 2142600.0 2257300.0 2099200.0 False True 2074584.3357999462 3158651.661663994 1549356.5453498908 1.0 1.5225467613713755 0.7468274577290053 20.984390876023852 -6.72523692320595 1.7403980953359495 1.3161293945155539 0.7476629965621602 0.5370515495257518 0.219762130600288 0.34528515765081746 2.0465975113689465 0.10015320075220348 0.24989364058589772 1.8826217716421806e-07 6.72523692320595 -0.5684663979533937 DVPLGTPLCIIVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVPLGTPLCIIVEK 14 0 P10515;H0YDD4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 27359000.0 2868200.0 19798000.0 4692800.0 False True 4351269.093507327 16264892.217519982 3765266.0230726884 1.0 3.7379651471772606 0.8653259410434916 22.053004808878796 -6.6571176165604795 1.9836234812406812 2.7666593538171353 0.8775122092158408 0.2231420590058758 1.1665925856599697 0.4913733871668687 3.713808480837796 0.47570870559447387 1.29243987158275 2.202329942576126e-07 6.6571176165604795 -1.8891471446012944 DVPLGTPLCIIVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVPLGTPLCIIVEK 14 0 P10515;H0YDD4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 23075300.0 5703800.0 10314000.0 7057500.0 False True 7812648.999399232 9858293.376163024 5390663.853775009 1.0 1.2618374864813582 0.6899918138123873 22.89738036869276 -6.782193113234513 1.5271500158323073 1.1478364445228715 0.6851323776125573 0.7751272891158566 0.11083695955869793 0.24718365828953542 1.1387513408274197 0.05715355586458283 0.1346232492344432 1.6512274007562244e-07 6.782193113234513 -0.4627040669103142 DVPLGTPLCIIVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVPLGTPLCIIVEK 14 0 P10515;H0YDD4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 6170300.0 2142600.0 1670300.0 2357400.0 False True 1781666.8332739444 1661301.7623714085 2850321.4406139236 1.0 0.9324424361195768 1.5998060846068776 20.76479615145813 -6.881966428652838 1.0688050027992417 0.9569369186581365 1.648915582204311 0.9752359013811618 0.04720125835146067 0.1259009513889809 0.26189935012138127 0.033957897961103184 0.08254255957093024 1.3123013371513398e-07 6.881966428652838 0.6919786635461744 DVPLGTPLCIIVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVPLGTPLCIIVEK 14 0 P10515;H0YDD4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 9145800.0 2868200.0 3402100.0 2875500.0 False True 3712941.4406744796 3212770.1443137485 2352188.5051215678 1.0 0.8652897428218335 0.6335108007236111 21.824131130971246 -6.962877653138798 0.39278050421165067 1.0138013623042021 0.47663393644282687 0.9998624861429799 0.0017749076188074368 0.07868875635988978 0.01744707875917621 0.0029883653636529573 0.019474211291676462 1.089236903464087e-07 6.962877653138798 -0.5371674258613752 DVPVVAILGSGGGFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVPVVAILGSGGGFR 15 0 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 0 2711810.0 640490.0 864120.0 1207200.0 False True 839688.5925139834 735196.6643133791 1082290.5242800855 1.0 0.8755587141088091 1.288918932481582 19.67949486264603 -6.825977235356373 1.345753923366523 0.9333000589622554 1.299158232201897 0.8975945023337495 0.05540929722010572 0.18582731832941302 0.6595825221434909 0.03234009202844174 0.07444944638882411 1.4928726602241815e-07 6.825977235356373 0.36585817323964165 DVPVVAILGSGGGFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVPVVAILGSGGGFR 15 0 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 0 2495980.0 640490.0 917950.0 937540.0 False True 877296.4615914335 877391.9337452825 716112.3612423976 1.0 1.0001088254176653 0.816271799322381 19.742704924168923 -6.906761326087859 0.9175135185388925 1.0062912225485967 0.7940894290794406 0.9896407670948579 0.00881783422135614 0.10659863511307344 0.1506750808969709 0.007105613572295355 0.019201140970102074 1.239477575351703e-07 6.906761326087859 -0.21220179346915613 DVQDSLTVSNEAQTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVQDSLTVSNEAQTAK 16 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 21185700.0 2581600.0 11411000.0 7193100.0 False True 3384502.6002499606 9708523.279729616 6448827.013087385 1.0 2.8685229194424604 1.9053987468087956 21.690512394592538 -10.019872206683155 5.74290173336185 0.9999967396875094 2.38696083312603 0.7343990869750883 0.39319379698353857 1.6414039228785756e-05 2.802479231783671e-06 0.3807091524938468 0.1269027522955681 9.552736387003489e-11 10.019872206683155 1.3869640934385208 DVQDSLTVSNEAQTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVQDSLTVSNEAQTAK 16 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 13697550.0 5265600.0 956450.0 7475500.0 False True 5098446.410243713 1338365.4728208582 5517442.289807125 1.0 0.2625045680840808 1.082181089267031 22.281626267840977 -6.66959779730216 1.9384356389853006 0.5291027043280658 1.07888775477956 0.2773853022178373 0.31330017104242847 0.46206215712754084 3.346765734729846 0.13012375233436577 0.347886498531361 2.1399429860035615e-07 6.66959779730216 0.5497850504514941 DVQDSLTVSNEAQTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVQDSLTVSNEAQTAK 16 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 13124600.0 2581600.0 5077600.0 5465400.0 False True 3536087.2851167736 4853254.842622196 4174585.08344626 1.0 1.3724929424251826 1.1805661871008937 21.75372245611543 -10.254257091561357 5.599501333785783 0.9999815526963297 1.2765295647630401 0.7346003709971407 0.078353769755444 1.80465320752503e-05 2.403425433576955e-06 0.07587076852277022 0.025288570447946503 5.5685600639792955e-11 10.254257091561357 0.2765480120667104 DVQDSLTVSNEAQTAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVQDSLTVSNEAQTAK 16 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 7807100.0 5265600.0 1423000.0 1118500.0 False True 4378579.705632067 1415334.016556615 1352373.1786403153 1.0 0.3232404367873224 0.30886115351532567 22.062031543275253 DVQEIFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVQEIFR 7 0 O00148;O00148-2;O00148-3;K7EQN7;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;A0A140T996;A0A140T9X9;F6UJC5;A0A140TA18;A0A140T9K1;A0A140T973;A0A140T9L4 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 6624800.0 2567800.0 1041900.0 3015100.0 False True 2486286.5945426566 1457936.1034367234 2225354.858938858 1.0 0.5863910084367829 0.8950516259161201 21.24556117492384 -9.878956289477541 6.908989628009221 1.0000000046610895 0.7407213171764485 0.484755808944325 0.12601016941947082 9.01771227433325e-09 1.5788761662566571e-09 0.122008823721664 0.040669607301197175 1.3214286255816137e-10 9.878956289477541 -0.259278687484641 DVQIGDIVTVGECRPLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVQIGDIVTVGECRPLSK 18 1 P62280;M0R1H5 P62280 RPS11 40S ribosomal protein S11 0 24920100.0 6617900.0 10355000.0 7947200.0 False True 8676130.987834768 8810074.363473859 7124899.978925368 1.0 1.0154381458540562 0.8212070551857207 23.04862040357838 -6.887672738468183 1.036091050692988 1.0110259968361837 0.805246056255472 0.9793649432759589 0.012662408230822384 0.1210500696088608 0.23306021450318512 0.009339546994940091 0.0230960230931162 1.295171447059183e-07 6.887672738468183 -0.2057799405807117 DVQIGDIVTVGECRPLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVQIGDIVTVGECRPLSK 18 1 P62280;M0R1H5 P62280 RPS11 40S ribosomal protein S11 0 62562300.0 4188300.0 58374000.0 0.0 False True 6353957.305744631 47956703.621856324 0.0 1.0 7.5475331851063165 0.0 22.599223965482373 -6.6773424920520315 1.9116977777330164 5.152602908662984 0.029532550304360052 0.31187586510349563 2.776634762024931 0.44443446906217904 3.1380283300902887 1.1665531719049147 3.0868045771776957 2.102120018143758e-07 6.6773424920520315 -5.123070358358624 DVQIGDIVTVGECRPLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVQIGDIVTVGECRPLSK 18 1 P62280;M0R1H5 P62280 RPS11 40S ribosomal protein S11 0 36979900.0 6617900.0 12936000.0 17426000.0 False True 9064716.472022902 12364444.7463685 13310337.699735515 1.0 1.364018917142063 1.468367790742952 23.11183046510127 -12.33123107607762 0.2004736915281187 2.8707924799427774e-09 1.5415657446564497 0.9994179866564018 0.004843493294729085 6.139519804338661 0.12915312564405035 2.5605076232340616 0.0659286655338875 4.664111498138539e-13 12.33123107607762 1.5415657417856572 DVQIGDIVTVGECRPLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVQIGDIVTVGECRPLSK 18 1 P62280;M0R1H5 P62280 RPS11 40S ribosomal protein S11 0 10465000.0 4188300.0 6276700.0 0.0 False True 5421836.913735769 5927396.127337266 0.0 1.0 1.0932450056401928 0.0 22.370350287574823 -6.9637860332869455 1.180085160521668 1.0561882184151572 2.0703053324093172e-20 0.9759642701647425 0.07671871169190844 0.10231114622652417 0.28209794576990443 0.054292647119301776 0.10205024241167152 1.0869610119360254e-07 6.9637860332869455 -1.0561882184151572 down DVRPYIVGAVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVRPYIVGAVVR 12 1 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 0 10054200.0 2967900.0 3055600.0 4030700.0 False True 3890945.641184487 2599716.3906355114 3613641.8292045547 1.0 0.6681451324115909 0.9287309981808137 21.891689394471392 -9.855110220003494 5.960631894569813 1.0000000302093914 0.7984380652959996 0.44374188283621396 0.10638373422005153 4.2674671848920574e-08 8.240219602985171e-09 0.1030056230841028 0.034335202578362506 1.396014020387321e-10 9.855110220003494 -0.20156196491339184 DVRPYIVGAVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVRPYIVGAVVR 12 1 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 0 10018400.0 2967900.0 1799600.0 5250900.0 False True 4065212.8344817506 1720087.721518611 4010745.5656800917 1.0 0.42312365712529654 0.9866016193937844 21.954899455994283 -10.951147345327277 10.262784815896207 1.0930379019252265 0.7048626382595415 0.26782365870709635 0.2300389148101713 0.11075387416548475 0.0005272073186139674 0.05037530223756876 0.074244740503285 1.1190581504273572e-11 10.951147345327277 -0.388175263665685 DVSDEK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVSDEKLR 8 1 O75390;B4DJV2;A0A0C4DGI3 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 1 3029790.0 743990.0 556800.0 1729000.0 True False 975378.0948094078 473727.6103894012 1550099.6657391235 1.0 0.4856861281900832 1.5892295244153685 19.895602046908294 -6.7799776671820755 1.5359096930851501 0.7087670437034331 1.5979695100655282 0.7672939236605026 0.21749585078950587 0.25062781880036705 1.1677968739164204 0.1115312731949565 0.2631771504098558 1.659672250923951e-07 6.7799776671820755 0.8892024663620951 DVSDEK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVSDEKLR 8 1 O75390;B4DJV2;A0A0C4DGI3 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 1 12281490.0 690190.0 2190100.0 9401200.0 True False 1047068.6896478005 1799259.5436705968 7543048.699307657 1.0 1.7183777544487635 7.20396739381529 19.997924658167545 -6.93097289212513 0.7387609384690549 0.9195189061752567 8.358555024504495 0.9967260352631037 0.15854233522105723 0.0921358672293909 0.07522799577216861 0.14528444717928535 0.49372290990353734 1.1722685341430101e-07 6.93097289212513 7.439036118329239 up DVSDEK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVSDEKLR 8 1 O75390;B4DJV2;A0A0C4DGI3 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 1 3485240.0 743990.0 292150.0 2449100.0 True False 1019063.2085737633 279241.84698914364 1870673.0207977886 1.0 0.27401818124702826 1.835679087478687 19.958812108431186 -6.7803032437693 1.5347805747550936 0.5890935740121113 1.8481494530602045 0.768435683934275 0.3070462433176893 0.25010099747376874 1.163671966245215 0.15757060866716607 0.3716921221649014 1.658428514337785e-07 6.7803032437693 1.2590558790480932 DVSDEK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVSDEKLR 8 1 O75390;B4DJV2;A0A0C4DGI3 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 1 8084810.0 690190.0 964720.0 6429900.0 True False 893464.5606788641 911032.4839429655 5259724.1763453875 1.0 1.0196626973662537 5.886886181975692 19.769050980259994 -6.907786742702488 0.9106827629558987 0.8385509739136865 6.4869846223137095 0.9900590122404841 0.22922859796226525 0.10589961066959912 0.14684391469622407 0.18564253133895497 0.504924529846722 1.2365544859040633e-07 6.907786742702488 5.648433648400023 up DVSLK(ub)DCMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVSLKDCMR 9 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 1412900.0 0.0 1412900.0 0.0 True False 0.0 1202100.827441063 0.0 0.0 DVSLK(ub)DCMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVSLKDCMR 9 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 794170.0 0.0 794170.0 0.0 True False 0.0 759080.9434310053 0.0 0.0 DVTADFEGQSPK(ub)CTQGVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVTADFEGQSPKCTQGVR 18 1 Q9UHL4 Q9UHL4 DPP7 Dipeptidyl peptidase 2 1 27255100.0 2647200.0 3255900.0 21352000.0 True False 3470504.835521267 2770132.411398794 19142699.862846557 1.0 0.7981929265869248 5.515825728556099 21.726714108418136 -6.8969079962938675 0.98062760877185 0.7868734945218889 5.981035242828379 0.9849636064636293 0.2670612977460583 0.11371650317873863 0.19054202053272798 0.20538710647851316 0.5265452649237566 1.267920441741623e-07 6.8969079962938675 5.19416174830649 up DVTADFEGQSPK(ub)CTQGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVTADFEGQSPKCTQGVR 18 1 Q9UHL4 Q9UHL4 DPP7 Dipeptidyl peptidase 2 1 21498900.0 3305300.0 2145600.0 16048000.0 True False 3200375.0607297462 3002349.269156185 11844547.370319657 1.0 0.9381241923787497 3.700987273541269 21.609809557732813 -6.901777085184713 0.9499519042674898 0.8906639769475713 4.0017078758885605 0.9874302385121028 0.14441409755035423 0.11010943290375955 0.17012874871414468 0.11362385179338237 0.2983592396922731 1.2537845527605535e-07 6.901777085184713 3.111043898940989 up DVTADFEGQSPK(ub)CTQGVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVTADFEGQSPKCTQGVR 18 1 Q9UHL4 Q9UHL4 DPP7 Dipeptidyl peptidase 2 1 172446000.0 8014200.0 59667800.0 104764000.0 True False 12158127.316500386 49019614.90335073 84057349.48030765 1.0 4.031839248534914 6.913675707790075 23.535417695685798 -7.312404271203223 0.2574385884335678 4.973442542333569e-16 10.048188872725396 0.9999234474588929 0.021125560263804664 0.11458849835909087 0.018610647172782928 0.15361351683175017 0.47193856968163417 4.8707487618066787e-08 7.312404271203223 10.048188872725396 DVTADFEGQSPK(ub)CTQGVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVTADFEGQSPKCTQGVR 18 1 Q9UHL4 Q9UHL4 DPP7 Dipeptidyl peptidase 2 1 36762200.0 2647200.0 3534300.0 30580700.0 True False 3625941.377890119 3378142.9396328274 23358168.489286248 1.0 0.9316595574963538 6.441959771252016 21.789924169941028 -6.9040914809833325 0.9350244899452007 0.7959037146687259 7.070955306124623 0.9884946176924333 0.2769130237182424 0.10845643090549702 0.16091554019454848 0.22028773655754325 0.5858705149998144 1.2471207896225415e-07 6.9040914809833325 6.275051591455897 up DVTADFEGQSPK(ub)CTQGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVTADFEGQSPKCTQGVR 18 1 Q9UHL4 Q9UHL4 DPP7 Dipeptidyl peptidase 2 1 46091900.0 3305300.0 2441800.0 40344800.0 True False 2748503.3996174564 2428645.538740649 48780711.14672132 1.0 0.8836247170291562 17.74809925776724 21.39021483316709 -6.905343384056405 0.9268445013353314 0.39787838563269257 19.723811116073875 0.9890429706415733 0.829315414448491 0.10757894827616978 0.15605870594221788 0.663712275524991 1.7781386072877439 1.243530999055294e-07 6.905343384056405 19.32593273044118 up DVTADFEGQSPK(ub)CTQGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVTADFEGQSPKCTQGVR 18 1 Q9UHL4 Q9UHL4 DPP7 Dipeptidyl peptidase 2 1 148474600.0 8014200.0 32986000.0 107474400.0 True False 10374539.883499546 31150300.102975603 87915161.98046865 1.0 3.002571723929598 8.474126367791557 23.306544017778247 -6.953531383253694 0.518630148076816 0.9060299696545863 10.814273417753622 0.9994500568859978 0.074080146917268 0.08209798543263741 0.030328156360408434 0.08410751881333299 0.4518936121763266 1.112931966524902e-07 6.953531383253694 9.908243448099036 DVTHTCPSCK(ub)AYIYTYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVTHTCPSCKAYIYTYK 17 1 Q9H305-3;Q9H305-2;Q9H305 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 1 127674000.0 47192000.0 52334000.0 28148000.0 True False 61869169.00797806 44525971.19633428 25235514.97468176 1.0 0.7196794770363351 0.4078851450457922 25.88271732082156 -6.969751244079984 0.2640633946952683 1.0833058951569376 0.03495887470588018 0.9999803752946197 0.001071346646425917 0.07638353087177754 0.009318739003411748 0.00634190957571852 0.029242642838898814 1.0721332276631228e-07 6.969751244079984 -1.0483470204510574 down DVTHTCPSCK(ub)AYIYTYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVTHTCPSCKAYIYTYK 17 1 Q9H305-3;Q9H305-2;Q9H305 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 1 133247000.0 78044000.0 43369000.0 11834000.0 True False 118398453.78065878 35629463.10645636 9495004.712973539 1.0 0.3009284493905839 0.08019534385612571 26.819074999377065 -10.066040480235651 0.2863132601287886 1.539740679259133 5.262420405436609e-19 0.9988854783270027 0.01308901634263444 1.5415909401336199 0.13352280969708996 0.7473764137779302 0.08266814078042904 8.589334572847051e-11 10.066040480235651 -1.539740679259133 DVTHTCPSCK(ub)AYIYTYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVTHTCPSCKAYIYTYK 17 1 Q9H305-3;Q9H305-2;Q9H305 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 1 122923000.0 47192000.0 49054000.0 26677000.0 True False 64640157.715847075 46886632.080114506 20376442.030061085 1.0 0.7253483552163403 0.31522884148325075 25.94592738234445 -6.991460728939413 0.3571737265837328 1.037155576192072 1.877553494492784e-14 0.9999200360224016 0.0025161142659967228 0.0747841708264024 0.014529272277180174 0.005502166329224131 0.03379234153741419 1.0198569764002889e-07 6.991460728939413 -1.0371555761920532 down DVTHTCPSCK(ub)AYIYTYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVTHTCPSCKAYIYTYK 17 1 Q9H305-3;Q9H305-2;Q9H305 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 1 20034000.0 8857600.0 1983100.0 9193300.0 True False 7365486.858213046 1972416.6466854715 11115576.524983468 1.0 0.2677917542526175 1.509143487587491 22.81234945978763 -6.746883281305654 1.6615138212447356 0.5678462262479473 1.511017952247632 0.635411236443036 0.3076420037246457 0.30550496137559324 1.6583826947301332 0.14633310437628533 0.3564088679514017 1.7910871524931085e-07 6.746883281305654 0.9431717259996846 DVTHTCPSCK(ub)AYIYTYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVTHTCPSCKAYIYTYK 17 1 Q9H305-3;Q9H305-2;Q9H305 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 1 119324000.0 78044000.0 27556000.0 13724000.0 True False 101029496.47723268 26022484.376329217 11226372.820131578 1.0 0.25757313738758925 0.11111975424584519 26.590201321469515 -13.999999999999993 0.2282093544913808 5.64821611563895 0.03868873260280411 0.9995074014766135 0.008636424616211358 13.236110104654031 0.15127141773409492 27.84986326396749 0.07687822410856264 1.0000000000000164e-14 13.999999999999993 -5.609527383036146 DVTHTCPSCK(ub)AYIYTYK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVTHTCPSCKAYIYTYKR 18 2 Q9H305-3;Q9H305-2;Q9H305 Q9H305-3 CDIP1 Cell death-inducing p53-target protein 1 2 7531600.0 2818200.0 2666900.0 2046500.0 True False 3860164.69899136 2549067.5397410477 1563158.8489905165 1.0 0.6603520156554732 0.4049461540848144 21.880230972607432 -7.7112577122348664 0.18372271737163196 1.2484653122930105 5.284377373298591e-12 0.9999368431366609 0.001937023409413978 0.13200952454921946 0.02307183820553957 0.05225598574762559 0.08481250824071662 1.9442060389281978e-08 7.7112577122348664 -1.248465312287726 down DVTLQK(ub)QCVPFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVTLQKQCVPFR 12 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 12150100.0 4087000.0 8063100.0 0.0 True False 5598074.347022111 7706845.580893934 0.0 1.0 1.3766958248765635 0.0 22.41649921653651 -6.863127611543173 1.3766318559260848 1.198481881376575 3.2915230697527276e-21 0.9122788231674066 0.17205489456038192 0.1626913549417845 0.6198911904902744 0.10087193057517423 0.20968401303749618 1.370479010326198e-07 6.863127611543173 -1.198481881376575 down DVTLQK(ub)QCVPFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVTLQKQCVPFR 12 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 28660900.0 11158600.0 2877300.0 14625000.0 True False 9278870.309796792 2861799.4138006647 17683019.88164021 1.0 0.3084211028123895 1.9057298239172686 23.145517739153014 -6.789075619365322 1.5004221581238055 0.6130118337607278 1.922193001107667 0.798190562910565 0.2938198581393706 0.23673582964066167 1.0529520111957036 0.15415813636271306 0.3611047910979191 1.6252657398032914e-07 6.789075619365322 1.3091811673469393 DVTNFTVGGFAPMSPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVTNFTVGGFAPMSPR 16 0 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 5117400.0 1117100.0 1819000.0 2181300.0 False True 1464528.91801179 1547612.2904064667 1955600.0005070835 1.0 1.056730441695524 1.3353099255711252 20.482005249711346 -6.940208783605784 0.6576200150674844 0.996883909747836 1.4108971839277673 0.9981910997544742 0.006232383646559472 0.08767152379679422 0.054177219860746154 0.006076394013660685 0.023954806686600674 1.1476017884628115e-07 6.940208783605784 0.4140132741799313 DVTNFTVGGFAPMSPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVTNFTVGGFAPMSPR 16 0 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 4828400.0 1117100.0 1886900.0 1824400.0 False True 1530122.05849239 1803530.5188561198 1393514.2946974325 1.0 1.1786840852638356 0.9107210022646459 20.545215311234237 -6.726975720695408 1.734347208525286 1.1078917086245916 0.9109688003451187 0.5451687766928157 0.07513394837460957 0.34192734338372255 2.0135186580712054 0.03435103410243627 0.08553024062699964 1.87509933287453e-07 6.726975720695408 -0.1969229082794729 DVTVYNPELDK(ub)WHNLESAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVTVYNPELDKWHNLESAPK 20 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 79842800.0 18267800.0 33234000.0 28341000.0 True False 23949262.705626857 28275616.74511739 25408545.18606853 1.0 1.1806466484028362 1.060932250749365 24.51347790650665 -10.439361835650443 5.221699623969936 0.9998572602650875 1.1207894495761026 0.5758016699590403 0.04887319818594975 8.130948255242996e-05 8.729884532710812e-06 0.04737705346824873 0.01577375688750519 3.6361196390200976e-11 10.439361835650443 0.12093218931101513 DVTVYNPELDK(ub)WHNLESAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVTVYNPELDKWHNLESAPK 20 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 73540900.0 21168900.0 32100000.0 20272000.0 True False 20496904.856770035 44917697.39928864 14962155.053035924 1.0 2.191438059217635 0.729971435082014 24.288902735653597 -6.68998456319832 1.866836142448344 1.7469917873065597 0.7350770833496181 0.37016837396081304 0.5038996470304797 0.41671286879145736 2.8157926419892583 0.21595265010878592 0.5622909079409694 2.0418105186146276e-07 6.68998456319832 -1.0119147039569416 DVTVYNPELDK(ub)WHNLESAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVTVYNPELDKWHNLESAPK 20 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 152428000.0 80627000.0 36323000.0 35478000.0 True False 122317053.62325335 29840876.857105702 28465757.74944023 1.0 0.24396333931504002 0.23272108758535928 26.866050319648675 DVTVYNPELDK(ub)WHNLESAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVTVYNPELDKWHNLESAPK 20 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 62806800.0 18267800.0 26439000.0 18100000.0 True False 25021899.328732673 25270837.557918753 13825152.781201228 1.0 1.0099488142732724 0.5525221167094134 24.576687968029542 -6.901928650217375 0.9489867130891584 1.0180248508747234 0.5025802606441245 0.9875018627772814 0.023848874862239834 0.10999979521782187 0.16951805511423537 0.018777574953611972 0.049346626092547266 1.2533470690966658e-07 6.901928650217375 -0.5154445902305989 DVTVYNPELDK(ub)WHNLESAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVTVYNPELDKWHNLESAPK 20 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 108816900.0 21168900.0 40869000.0 46779000.0 True False 17602878.291278258 40648830.58513866 56560272.618341796 1.0 2.3092149995310165 3.2131263809490664 24.069308011087873 -8.082635035705758 0.18625971081622916 3.709046350298644e-17 4.511115055757033 0.9998580251527996 0.010825560423448715 0.09643775034497598 0.03556506561294156 0.3326046709103403 0.3986579873845097 8.267324116968721e-09 8.082635035705758 4.511115055757033 DVTVYNPELDK(ub)WHNLESAPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVTVYNPELDKWHNLESAPK 20 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 156835000.0 80627000.0 39211000.0 36997000.0 True False 104373240.89577478 37028873.38076082 30263925.621277228 1.0 0.3547736284028698 0.2899586652818248 26.637176641741124 -13.999999999999998 0.32482330704907036 7.808784179164595 0.2777723964960522 0.999703997761647 0.005514688335816386 18.395494077858896 0.18198545481795095 85.33634065196998 0.021180496511211167 1.0000000000000041e-14 13.999999999999998 -7.531011782668543 DVVEPLLRPQWYVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVVEPLLRPQWYVR 14 1 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 5034000.0 1058700.0 1980800.0 1994500.0 False True 1387965.9524653854 1685272.3610979277 1788128.2725949555 1.0 1.2142029551261322 1.2883084555631776 20.40454074760648 -13.889599178884286 0.14912488768937135 1.4974423367893107e-07 1.3710938316547725 0.9995686374443653 0.002538949179173825 11.506725745222473 0.1207661543102483 3.348157322608965 0.07418105026285478 1.2894390578855556e-14 13.889599178884286 1.3710936819105388 DVVICPDASLEDAKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVVICPDASLEDAKK 15 1 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 39778700.0 1396000.0 29444000.0 8938700.0 False True 1830169.518883229 25051069.97181306 8013809.0700649535 1.0 13.687841324720152 4.378725023764458 20.80354585320261 -9.334109472836388 9.743030471383864 0.9998603017501768 9.033283174242944 0.49822009565164904 3.8004308164506218 0.0 0.0 3.679751314744816 1.226583771581605 4.633301131520688e-10 9.334109472836388 8.033422872492768 DVVICPDASLEDAKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVVICPDASLEDAKK 15 1 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 48978300.0 1396000.0 37943000.0 9639300.0 False True 1912138.9254814903 36266552.799278 7362695.86761509 1.0 18.96648424232346 3.850502580904842 20.866755914725502 -9.570587114644766 9.803354491786427 1.0000104610374303 11.40849341164645 0.38732303131489876 6.171073671960212 0.0 0.0 5.975116211858425 1.9917054633096334 2.6878986264044195e-10 9.570587114644766 10.40848295060902 DVVK(ub)VGAVDADK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVVKVGAVDADK 12 1 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 1 5414170.0 1332800.0 754270.0 3327100.0 True False 1747313.7068535613 641735.8561214323 2982843.607796777 1.0 0.36726997196000066 1.7071025060337164 20.736707217471146 -6.778261127340059 1.542402004854745 0.6409254536625762 1.717190969963394 0.7612804174081219 0.2673879485210161 0.2532786559203635 1.1899943676271745 0.13655079214630228 0.3227067508192674 1.666245051600265e-07 6.778261127340059 1.076265516300818 DVVK(ub)VGAVDADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVVKVGAVDADK 12 1 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 1 18668700.0 0.0 2300700.0 16368000.0 True False 0.0 3219381.507992001 12080729.770525444 0.0 DVVK(ub)VGAVDADK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVVKVGAVDADK 12 1 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 1 25596200.0 1512200.0 10624000.0 13460000.0 True False 2294117.956628472 8728064.194309136 10799625.100272417 1.0 3.8045402892605615 4.707528254625573 21.129508141614227 -9.374293747570977 0.3593479498525218 1.4772411764431383e-21 4.915857472065319 0.9982912697689212 0.06525250768603623 0.7463928939261244 0.1423082775785412 1.232979738445323 0.25570195843130716 4.223828268459402e-10 9.374293747570977 4.915857472065319 DVVK(ub)VGAVDADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVVKVGAVDADK 12 1 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 1 7630790.0 1332800.0 815590.0 5482400.0 True False 1825572.1775657122 779554.5370045374 4187570.0335722417 1.0 0.42701929103894715 2.2938397533841184 20.799917278994037 -6.824323016139356 1.353163215504039 0.6924461780398103 2.338466618807139 0.8940179553743256 0.25420032286228855 0.1879243559512856 0.6749372707479634 0.14757906531225468 0.3398016505560696 1.4985698263997903e-07 6.824323016139356 1.6460204407673285 up DVVK(ub)VGAVDADK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVVKVGAVDADK 12 1 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 1 10444700.0 0.0 3295800.0 7148900.0 True False 0.0 3278044.8712349166 8643701.937221041 0.0 DVVK(ub)VGAVDADK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVVKVGAVDADK 12 1 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 1 20392000.0 1512200.0 12868000.0 6011800.0 True False 1957572.7099183984 12151884.488118893 4917714.086277109 1.0 6.207628675322842 2.512148877720156 20.900634463706677 -6.557037832109046 2.3586133151482556 4.593761926055891 2.5175161804038644 0.0 2.2754222297039974 0.7710309748292526 8.035208068847693 0.8224038234040423 2.5624013716954073 2.773078526682924e-07 6.557037832109046 -2.076245745652027 DVVPTNLK(ub)NEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVVPTNLKNEK 11 1 Q13415 Q13415 ORC1 Origin recognition complex subunit 1 1 5582600.0 2861100.0 1691100.0 1030400.0 True False 3750929.8069318146 1438794.471856172 923784.0922947313 1.0 0.38358341688965836 0.24628135951452745 21.838816834685886 -13.999999999999977 0.21102275746109778 4.58002764516112 0.16620780620811768 0.9994906104863593 0.007397710361693323 12.770843670711965 0.14559464746361558 18.965449265141416 0.08075219841510485 1.0000000000000532e-14 13.999999999999977 -4.413819838953002 DVVPTNLK(ub)NEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVVPTNLKNEK 11 1 Q13415 Q13415 ORC1 Origin recognition complex subunit 1 1 7409000.0 1844000.0 2641100.0 2923900.0 True False 1785463.2293545688 3695705.003154551 2158042.8748802147 1.0 2.0698858102446165 1.2086739392893187 20.76786699203333 -10.157687378697192 4.564161659863692 0.999908541924717 1.639279874777808 0.42352624425422636 0.35158827408172305 246133662.17925477 42.25669600488036 236585.72548046114 0.1203580179125063 6.95524802025896e-11 10.157687378697192 0.6393713328530909 DVVPTNLK(ub)NEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVVPTNLKNEK 11 1 Q13415 Q13415 ORC1 Origin recognition complex subunit 1 1 15125900.0 3424000.0 6834800.0 4867100.0 True False 4432435.497130405 6454437.371727942 3981337.7406632514 1.0 1.456183034340059 0.8982280155550604 22.07966820582948 -6.689392127150691 1.8689420740893075 1.2861627268026434 0.9001881684141163 0.3674812130779933 0.19295716216113087 0.41793985779402587 2.829994328771451 0.08261571179066945 0.21527299226778646 2.044597723234143e-07 6.689392127150691 -0.3859745583885271 DVVPTNLKNEK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVVPTNLKNEK 11 1 Q13415 Q13415 ORC1 Origin recognition complex subunit 1 1 4061800.0 1321600.0 1150200.0 1590000.0 True False 1732630.3983926072 978594.6434444851 1425482.0523569721 1.0 0.56480288257227 0.8227271400059804 20.724532503525044 -10.25859960517879 5.748992169476377 1.0000167397799598 0.6937650112891217 0.6527287836118123 0.10529713716648653 2.259344788022507e-05 2.9137792838209044e-06 0.10195908232078159 0.03398450488742481 5.5131574394570256e-11 10.25859960517879 -0.30625172849083804 DVVPTNLKNEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVVPTNLKNEK 11 1 Q13415 Q13415 ORC1 Origin recognition complex subunit 1 1 7320300.0 1653700.0 2113600.0 3553000.0 True False 1601204.1986896137 2957571.502278394 2622362.712284757 1.0 1.8470920228030867 1.6377440893740063 20.61072587321294 -10.136221894989372 4.462317739180505 0.999914569487344 1.7424180559571212 0.9437211436286266 0.08546593668134166 13036338.356970713 14806134.634188 10846.73420316847 0.029257264719112996 7.307656164762125e-11 10.136221894989372 0.7425034864697772 DVVSGSEVLHWVTHFPYPMYSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVVSGSEVLHWVTHFPYPMYSR 22 0 Q9NQZ5;C9JTD3 Q9NQZ5 STARD7 StAR-related lipid transfer protein 7, mitochondrial 0 20312800.0 5720200.0 6133300.0 8459300.0 False True 7404911.661999222 5791976.4633959895 6919794.199747827 1.0 0.7821803591688273 0.9344870696107103 22.82005109409477 -9.996042769010707 5.113263016042817 1.0000010417634793 0.858333714466049 0.5356488610165263 0.06217895416767 7.3845109178816e-07 1.449230524947331e-07 0.060204956661897166 0.02006817116414864 1.0091535004663624e-10 9.996042769010707 -0.14166732729743026 DVVSK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVVSKLR 7 1 Q5TA50;J3KST3 Q5TA50 CPTP Ceramide-1-phosphate transfer protein 1 7820900.0 2016500.0 2218000.0 3586400.0 True False 2643651.027813778 1887083.0456962858 3215313.731178013 1.0 0.7138169999906714 1.2162398506269505 21.334100317398836 -6.752194780999152 1.6416145104134732 0.8321652459340353 1.2174138087702564 0.6583793532742859 0.12027187061168636 0.29624539849860293 1.5713851043498444 0.05785826403178249 0.14014801679370076 1.7693152427632526e-07 6.752194780999152 0.3852485628362211 DVVSK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVVSKLR 7 1 Q5TA50;J3KST3 Q5TA50 CPTP Ceramide-1-phosphate transfer protein 1 13546700.0 1984800.0 2766100.0 8795800.0 True False 1921793.610424593 3870618.1550209415 6491916.111656144 1.0 2.01406547197635 3.378050627518658 20.87402197660906 -6.967005627195616 0.3217777601477282 0.8170568300419706 4.619169230387014 0.9999487183049608 0.006977311162628041 0.07728681894920492 0.012494258752443506 0.020528510921154246 0.11979221858366282 1.078932742303341e-07 6.967005627195616 3.802112400345043 DVVSK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVVSKLR 7 1 Q5TA50;J3KST3 Q5TA50 CPTP Ceramide-1-phosphate transfer protein 1 50474500.0 6867500.0 20635000.0 22972000.0 True False 10418499.581501147 16952523.028009135 18431574.131014727 1.0 1.6271558966235073 1.7691198225646056 23.312644187299103 -11.314336409007943 0.2677329838307354 4.009672411327281e-17 1.8251427563717029 0.9992851633915105 0.008934498338339852 3.541392978289954 0.14481912468270822 2.1508850419729884 0.05937763995861294 4.84912736213102e-12 11.314336409007943 1.8251427563717029 DVVSK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVVSKLR 7 1 Q5TA50;J3KST3 Q5TA50 CPTP Ceramide-1-phosphate transfer protein 1 7254900.0 2016500.0 1576800.0 3661600.0 True False 2762054.543863487 1507131.7622196858 2796805.493019139 1.0 0.5456560463543746 1.0125815578960449 21.397310378921727 -10.984709535825578 11.509763056764822 1.1472885983230288 0.7791188021252098 0.22980591646874737 0.19062154186085162 0.07461331642901818 9.912208983402081e-05 0.01911458864187932 0.06152283808795486 1.0358347204584173e-11 10.984709535825578 -0.368169796197819 DVVSK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVVSKLR 7 1 Q5TA50;J3KST3 Q5TA50 CPTP Ceramide-1-phosphate transfer protein 1 12115400.0 1984800.0 4129800.0 6000800.0 True False 1650449.141548644 4107551.947698879 7255539.535435665 1.0 2.4887479682316624 4.39610003894314 20.654427252043337 -6.967745242449551 0.30731454499109173 0.6966806284649245 6.248561313349239 0.9999590661852652 0.008892887634366064 0.07704138620111706 0.011635713352320842 0.030551549956313293 0.1697830171476904 1.0770968543762804e-07 6.967745242449551 5.551880684884314 DVVSK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVVSKLR 7 1 Q5TA50;J3KST3 Q5TA50 CPTP Ceramide-1-phosphate transfer protein 1 42696500.0 6867500.0 16473000.0 19356000.0 True False 8890114.128663274 15556263.069069205 15833406.609331608 1.0 1.7498383984647743 1.7810127496881005 23.083770509391552 -11.20271850640213 0.536300383411774 1.9250649822576943e-15 1.7786356802491932 0.9998743202901603 0.004047611642433541 3.362362914758235 0.2629027012541326 4.036897774058586 0.005950913415899287 6.2702014422449036e-12 11.20271850640213 1.7786356802491912 DVVVQK(ub)QMAFMLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVVVQKQMAFMLGR 14 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 16905100.0 0.0 9859500.0 7045600.0 True False 0.0 8099995.192374891 5653034.071803825 0.0 DVVVQK(ub)QMAFMLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVVVQKQMAFMLGR 14 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 16902200.0 0.0 8162300.0 8739900.0 True False 0.0 7708060.829761649 7149327.878946956 0.0 DVWSNEAVK(ub)NIIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DVWSNEAVKNIIR 13 1 O94888;C9JAT7 O94888 UBXN7 UBX domain-containing protein 7 1 8375000.0 2490800.0 3632900.0 2251300.0 True False 3265462.9209415135 3090885.4809332876 2018357.0719944974 1.0 0.9465382262071771 0.6180921727975265 21.63885609598287 -6.935336483415311 0.7016063250949839 1.0041462632923852 0.5404820476182135 0.9974870282099487 0.008464300936024526 0.08996006021533531 0.06478935889117121 0.007972860546038078 0.028896684075955432 1.1605490932243903e-07 6.935336483415311 -0.4636642156741717 DVWSNEAVK(ub)NIIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVWSNEAVKNIIR 13 1 O94888;C9JAT7 O94888 UBXN7 UBX domain-containing protein 7 1 16561900.0 4811400.0 5800700.0 5949800.0 True False 4658664.740627203 8116949.760250879 4391368.889826018 1.0 1.7423339545051877 0.9426239350365447 22.15148508040202 -6.6629084309471756 1.9627273723268395 1.4766921232919579 0.9459514788088169 0.24794846387015113 0.3158524928226102 0.47760409499828027 3.539927490807429 0.12988208157279732 0.350225872653991 2.173159331506421e-07 6.6629084309471756 -0.530740644483141 DVWSNEAVK(ub)NIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVWSNEAVKNIIR 13 1 O94888;C9JAT7 O94888 UBXN7 UBX domain-containing protein 7 1 9911600.0 2490800.0 2967500.0 4453300.0 True False 3411716.0713390415 2836386.0377897783 3401522.258592461 1.0 0.8313663794058174 0.997012115740751 21.70206615750576 -10.74804841408454 8.280162289811878 1.0007036256932151 0.9141892475750433 0.26352402451559953 0.06762458868136445 0.0008854359001157371 2.6942253294473284e-05 0.06600247610557573 0.02182574214642094 1.7862884326954037e-11 10.74804841408454 -0.08651437811817186 DVWSNEAVK(ub)NIIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVWSNEAVKNIIR 13 1 O94888;C9JAT7 O94888 UBXN7 UBX domain-containing protein 7 1 12096100.0 4811400.0 3038800.0 4245900.0 True False 4000892.281160386 3022429.3812454287 5133698.059176501 1.0 0.7554388293525434 1.2831382847647088 21.931890355836295 -6.78069617776488 1.5332563696632733 0.8616481903120644 1.2874027125294125 0.7698115262973593 0.10345209547796179 0.24949549080266242 1.1585747945271891 0.053141146138404975 0.1253128630056882 1.656928706574844e-07 6.78069617776488 0.4257545222173481 DVWSNEAVK(ub)NIIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVWSNEAVKNIIR 13 1 O94888;C9JAT7 O94888 UBXN7 UBX domain-containing protein 7 1 36920800.0 5226800.0 9227000.0 22467000.0 True False 6766195.635631182 8713509.33881514 18378236.530887254 1.0 1.2878003841522538 2.716184621400301 22.689913460685244 -6.939970482828278 0.6598369265224654 0.9839588638276678 3.1010416135610077 0.9981600462544009 0.032189752882382995 0.0877800750884103 0.05467076298587136 0.03132732278801848 0.1229541437602997 1.1482316593277456e-07 6.939970482828278 2.1170827497333398 up DVYK(ub)EHFQDDVFNEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVYKEHFQDDVFNEK 15 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 14737200.0 3176600.0 4389200.0 7171400.0 True False 3075760.571782931 6141830.449375623 5292995.202611569 1.0 1.9968493340219189 1.7208736112848244 21.55251177244657 -10.103153810335208 5.055764459299737 0.9999748999906576 1.8588614726557207 0.9281272434973491 0.1126666170251101 3.187687900776116e-05 5.65498287822521e-06 0.10909216267429295 0.03636299428314519 7.885807832943645e-11 10.103153810335208 0.8588865726650631 DVYK(ub)EHFQDDVFNEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVYKEHFQDDVFNEK 15 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 13797600.0 1972500.0 3841300.0 7983800.0 True False 2701786.5548081947 3671578.664519582 6098190.871522339 1.0 1.3589447537909725 2.2570957208554403 21.36548227341667 -6.955442782489363 0.4955033830991938 0.9812901521177985 2.67319339113174 0.9995620765033187 0.011064107762047425 0.08137103507052079 0.027466260029598916 0.013087760993020555 0.0740805944627732 1.1080445386173578e-07 6.955442782489363 1.6919032390139415 up DVYK(ub)EHFQDDVFNEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVYKEHFQDDVFNEK 15 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 12263500.0 3176600.0 3227700.0 5859200.0 True False 2641483.6472407407 3210311.739451713 7084331.630120092 1.0 1.2153441656945947 2.681951727212202 21.332917047880848 -6.933217177758962 0.7199004867024789 0.9801399935602897 3.009281291105012 0.9971335418554714 0.04001055324093476 0.09100144232645416 0.06974801219374396 0.037175907340060495 0.130434761861962 1.1662262761282366e-07 6.933217177758962 2.0291412975447223 up DVYNHFLLYYGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVYNHFLLYYGR 12 0 Q7KZ85;Q7KZ85-3 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 8489260.0 2555900.0 791860.0 5141500.0 False True 2474764.3535289257 1108053.8274953484 3794786.9083062364 1.0 0.4477411459055902 1.5333932311151184 21.238859727978866 -6.768417556904737 1.58045565338706 0.6825966902972178 1.5391443962762175 0.7244768452092138 0.23265690846671574 0.2690039217463103 1.3258245746609876 0.11604875421183929 0.2766533986785177 1.7044428468138571e-07 6.768417556904737 0.8565477059789997 DVYVQLYLQHLTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DVYVQLYLQHLTAR 14 0 G5E972;P42167;P42167-2;P42167-3;P42166 G5E972;P42166 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 0 67924500.0 47395000.0 7750700.0 12778800.0 False True 45890471.66771134 10845594.92936653 9431648.9242174 1.0 0.23633653207791108 0.2055252121292432 25.45169129922869 -13.263738346180688 0.46579023667463865 9.998797057924094 0.20608305049454168 0.9999035039897387 0.003609760965832617 19.084183831620855 0.23443561141670377 173.29544785712346 0.0067207099918236 5.448308037431067e-14 13.263738346180688 -9.792714007429552 DVYVQLYLQHLTAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DVYVQLYLQHLTAR 14 0 G5E972;P42167;P42167-2;P42167-3;P42166 G5E972;P42166 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 0 1013000000.0 235650000.0 338640000.0 438710000.0 False True 357498278.32264185 278207046.1936039 351998776.2065765 1.0 0.778205275558061 0.984616703213597 28.41336105312596 -10.480322733119552 7.731735523089684 1.000011377248962 0.8814109894133874 0.3056080687896411 0.0842671124725779 1.6527804075212245e-05 1.1108601610646807e-06 0.08159910550206177 0.02719709360327344 3.30885142575232e-11 10.480322733119552 -0.1186003878355747 DVYVQLYLQHLTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DVYVQLYLQHLTAR 14 0 G5E972;P42167;P42167-2;P42167-3;P42166 G5E972;P42166 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 0 4988730.0 4176000.0 812730.0 0.0 False True 5719980.0521566635 776820.9012612918 0.0 1.0 0.1358083234867924 0.0 22.447578685085734 -10.227851831537974 0.42785459031616185 1.4672309306083229 4.1790651263674186e-24 0.9989302622180614 0.014485153125558432 1.7664258155026524 0.22029388096632116 1.0103428569905983 0.032956434484016785 5.917634919812081e-11 10.227851831537974 -1.4672309306083229 DVYVQLYLQHLTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DVYVQLYLQHLTAR 14 0 G5E972;P42167;P42167-2;P42167-3;P42166 G5E972;P42166 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 0 65660400.0 47395000.0 4214300.0 14051100.0 False True 39411042.45450316 4191596.729426943 16989120.045054022 1.0 0.10635589592094145 0.431075124812204 25.232096574662965 -10.498690778598677 6.161686919436787 1.0005959034361025 0.2687155110163927 0.8711724657805276 0.1325660700756019 0.0010860060040170762 8.835641561652403e-05 0.12845190244424018 0.04278551513958095 3.171825025907678e-11 10.498690778598677 -0.7318803924197098 DVYVQLYLQHLTAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DVYVQLYLQHLTAR 14 0 G5E972;P42167;P42167-2;P42167-3;P42166 G5E972;P42166 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 0 859440000.0 235650000.0 268860000.0 354930000.0 False True 305053570.3559517 253897704.65306562 290336381.8893403 1.0 0.8323053041365984 0.9517553967670704 28.18448737521841 -10.480258258464941 4.685875464477179 1.0003961472242242 0.8920303504518036 0.5213832217083882 0.048765296112245886 0.00020255488866345687 2.246672274303957e-05 0.04738919457155375 0.015738931642951863 3.309342688935124e-11 10.480258258464941 -0.10836579677242064 DWAEK(ub)QPPFTLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DWAEKQPPFTLIR 13 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 20825700.0 5358300.0 7870300.0 7597100.0 True False 7024783.189851014 6696081.918189112 6811024.968529032 1.0 0.9532083392784577 0.9695708443171873 22.74402226857181 -10.704958913728511 5.594808345719205 1.000862990592263 0.9613895917978225 0.8812938722012715 0.006679964709767706 7.350638157418979e-05 3.8763315243138164e-06 0.006611768612361137 0.0021559493395152947 1.9726093452772562e-11 10.704958913728511 -0.03947339879444056 DWAEK(ub)QPPFTLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DWAEKQPPFTLIR 13 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 27278300.0 8932700.0 9104400.0 9241200.0 True False 8649136.32801278 12739834.39881879 6820652.489942551 1.0 1.4729602951865932 0.7885934769986057 23.044124646870973 -6.720793270272042 1.756508270774797 1.2875024707908926 0.789616944463487 0.5162138102579098 0.19900464917243363 0.35379058603786107 2.1336952437808123 0.08994419644034127 0.22557915071527768 1.901983432914207e-07 6.720793270272042 -0.4978855263274057 DWAEK(ub)QPPFTLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DWAEKQPPFTLIR 13 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 24224300.0 5358300.0 8301000.0 10565000.0 True False 7339408.312612807 7934234.372263831 8069764.5930050295 1.0 1.081045505893004 1.0995116022005618 22.807232330094703 -13.999999996173969 0.20781660567226967 0.5354400495803487 1.1106211526616974 0.9994888847421618 0.000977100810347479 12.696374131803532 0.14450500915414036 2.4058258850475998 0.011108041384879698 1.0000000088097621e-14 13.999999996173969 0.5751811030813486 DWAEK(ub)QPPFTLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DWAEKQPPFTLIR 13 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 25917800.0 8932700.0 7918600.0 9066500.0 True False 7427935.835707162 7875940.930080967 10962263.231240433 1.0 1.060313538549994 1.4758155527600614 22.82452992230525 -6.932985852128216 0.7218573804519786 0.9943282836653115 1.5679876803101276 0.9970933397804812 0.011403965640308905 0.09111657850086366 0.07029905913683947 0.01058068799020835 0.036997809404856336 1.1668476284620618e-07 6.932985852128216 0.5736593966448161 DWAEK(ub)QPPFTLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DWAEKQPPFTLIR 13 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 46669000.0 13664000.0 12305000.0 20700000.0 True False 17688317.35770732 11620215.933035677 16932812.399936154 1.0 0.6569429809541724 0.9572879125530857 24.076293479048825 -10.200968542809349 7.466474152009088 1.0000002086172002 0.8071154478612368 0.3548019856631244 0.12261530487474222 4.2584338945098445e-07 4.549221043429747e-08 0.11872188758480207 0.03957391948083514 6.295517814407124e-11 10.200968542809349 -0.1928847607559634 DWCPWVNITLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DWCPWVNITLGK 12 0 C9J0I9;Q86WB0-3;Q86WB0-2;Q86WB0 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 0 29564300.0 8280800.0 7970500.0 13313000.0 False True 12562579.007571125 6548102.001199253 10681679.714704804 1.0 0.5212386721908686 0.8502776148326905 23.582629333814356 -10.097866967507834 5.614332731932947 1.000002706381518 0.6857581435117202 0.5487584838080104 0.13432958582977472 4.5505982665371455e-06 7.311604900331874e-07 0.13006518227415678 0.04335468740177369 7.982391653521827e-11 10.097866967507834 -0.31424456286979785 DWCPWVNITLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DWCPWVNITLGK 12 0 C9J0I9;Q86WB0-3;Q86WB0-2;Q86WB0 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 0 21519900.0 8280800.0 6573500.0 6665600.0 False True 10719658.838971218 6207678.946429096 5452529.194831618 1.0 0.5790929580576891 0.5086476423119922 23.353755655906806 -13.999999999999998 0.25152113406931403 3.949800824355615 0.4807297312258018 0.9995455680014423 0.004624517666056725 14.05885160960621 0.1586964401847301 20.971767053642207 0.03223760051413531 1.0000000000000041e-14 13.999999999999998 -3.469071093129813 DWEMHVHFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DWEMHVHFK 9 0 D6RIU4;D6RBH1;D6RDX1;D6RBV2;Q12907 D6RIU4 LMAN2 Vesicular integral-membrane protein VIP36 0 5530400.0 2104400.0 1908700.0 1517300.0 False True 2758888.7790385876 1623929.4000543263 1360304.3509693285 1.0 0.5886172042862235 0.49306241023727126 21.395655866840386 -13.999999999999998 0.20509309428238695 3.33250147478962 0.4340286787497937 0.9994878511129349 0.004977336045454614 12.636229266459322 0.14357256819721956 11.849710235348544 0.05861219546634374 1.0000000000000041e-14 13.999999999999998 -2.8984727960398264 DWETK(ub)NFDFEDVFVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DWETKNFDFEDVFVK 15 1 A0A3B3ISG8;Q16795 A0A3B3ISG8 NDUFA9 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial 1 4036900.0 1321700.0 0.0 2715200.0 True False 1279743.3569620028 0.0 2004007.6657460113 1.0 0.0 1.5659449645461319 20.287423086766694 -6.734188285690085 1.7078230187592933 0.4010394471503396 1.565776969140994 0.5786501383701473 0.42025558399104723 0.32843120667282477 1.8784461763471143 0.19485377286750347 0.4812658645695183 1.8442156975104737e-07 6.734188285690085 1.1647375219906544 DWIFAVAWLSDTVAVSGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DWIFAVAWLSDTVAVSGSR 19 0 Q5VW00;Q5VU92 Q5VW00 DCAF12L2;DCAF12L1 DDB1- and CUL4-associated factor 12-like protein 2;DDB1- and CUL4-associated factor 12-like protein 1 0 49192000.0 16564000.0 20746000.0 11882000.0 False True 21715564.40600419 17650777.667274605 10652564.620192166 1.0 0.812816896547911 0.4905497467635155 24.37222611436284 -6.962866102064795 0.392960008402308 1.0191512810092453 0.2725808899533871 0.9998621739841272 0.002470136282547487 0.07869275220391227 0.01746135674134212 0.004154720614889798 0.027075100406559402 1.0892658746436125e-07 6.962866102064795 -0.7465703910558583 down DWIFAVAWLSDTVAVSGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DWIFAVAWLSDTVAVSGSR 19 0 Q5VW00;Q5VU92 Q5VW00 DCAF12L2;DCAF12L1 DDB1- and CUL4-associated factor 12-like protein 2;DDB1- and CUL4-associated factor 12-like protein 1 0 328180000.0 94035000.0 60605000.0 173540000.0 False True 142657969.8793535 49789564.24097379 139239742.93471578 1.0 0.3490135481605483 0.9760390047080544 27.087985107380124 -10.938096985167869 10.339860964551363 1.0772985587939212 0.6625262764343018 0.2786200585916515 0.25598207071284257 0.12803601251911728 0.0007665291848190011 0.06957125375744738 0.08261785806654405 1.1531957013186395e-11 10.938096985167869 -0.4147722823596194 DWIFAVAWLSDTVAVSGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DWIFAVAWLSDTVAVSGSR 19 0 Q5VW00;Q5VU92 Q5VW00 DCAF12L2;DCAF12L1 DDB1- and CUL4-associated factor 12-like protein 2;DDB1- and CUL4-associated factor 12-like protein 1 0 55356000.0 16564000.0 21854000.0 16938000.0 False True 22688158.425268944 20888418.01848619 12937593.24906004 1.0 0.9206749012833808 0.570235494946597 24.43543617588573 -6.942600777510613 0.6349165809305157 1.0038262493721555 0.46803787090084803 0.998484981766355 0.0072679590342870646 0.08660018861222352 0.049356992648590746 0.00722284734267174 0.02983326575274162 1.1412984369634365e-07 6.942600777510613 -0.5357883784713074 DWIFAVAWLSDTVAVSGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DWIFAVAWLSDTVAVSGSR 19 0 Q5VW00;Q5VU92 Q5VW00 DCAF12L2;DCAF12L1 DDB1- and CUL4-associated factor 12-like protein 2;DDB1- and CUL4-associated factor 12-like protein 1 0 50456000.0 23320000.0 10148000.0 16988000.0 False True 19391613.251166057 10093330.709779719 20540112.25636266 1.0 0.5204997943723318 1.05922658369476 24.208929495126128 -6.671930975032419 1.9306558745963742 0.6944472657613409 1.0570635447340022 0.2876170186045808 0.20359075499792098 0.4566714678103175 3.2835633646941793 0.08484164360447612 0.22609585317009015 2.1284773104756241e-07 6.671930975032419 0.36261627897266135 DWILPSDYDHAEAEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DWILPSDYDHAEAEAR 16 0 O43852;O43852-3;O43852-5;O43852-9;O43852-15;H0Y875;O43852-2;O43852-4 O43852;O43852-2 CALU Calumenin 0 11976900.0 2555300.0 1473400.0 7948200.0 False True 2474183.4002005057 2061736.3036794972 5866327.979111086 1.0 0.8332997074963868 2.3710158182435803 21.238521014162735 -6.880046401049709 1.0795051724468654 0.8966106668452801 2.480105189219396 0.9737243590534853 0.11167945159605297 0.12759061071246225 0.27201839024927443 0.07968788923327955 0.19273411783036437 1.318115900412183e-07 6.880046401049709 1.583494522374116 up DWLVK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DWLVKQR 7 1 Q07820;A0A087WT64 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 39715500.0 5144500.0 16731000.0 17840000.0 True False 7804582.6133283805 13745222.330100363 14313916.18045022 1.0 1.761173276150191 1.8340399339236204 22.895890048704462 -11.187090316446731 0.4104885142747752 9.284275195295183e-20 1.838373681721203 0.999612539607619 0.00742422308206494 3.1972420144377764 0.20278908570996215 2.9561233909229974 0.018089782918151567 6.499945025823841e-12 11.187090316446731 1.838373681721203 DWNVDLIPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DWNVDLIPK 9 0 P31150;G5E9U5;P50395;P50395-2;Q5SX87;Q5SX86;V9GYJ7;V9GYF8;Q5SX90 P31150;P50395 GDI1;GDI2 Rab GDP dissociation inhibitor alpha;Rab GDP dissociation inhibitor beta 0 11768400.0 1311900.0 4879800.0 5576700.0 False True 1719913.6044576722 4151752.861311421 4999676.579483731 1.0 2.4139310547639763 2.9069347242358967 20.71390466590796 -9.814620485084404 0.27514044527801196 3.395017449362063e-12 3.133749556500838 0.9989425563049723 0.026281267046643488 1.2187809965726655 0.11910339000226716 1.1915425223281055 0.1943052284900746 1.5324260107902863e-10 9.814620485084404 3.133749556497443 DWNVDLIPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DWNVDLIPK 9 0 P31150;G5E9U5;P50395;P50395-2;Q5SX87;Q5SX86;V9GYJ7;V9GYF8;Q5SX90 P31150;P50395 GDI1;GDI2 Rab GDP dissociation inhibitor alpha;Rab GDP dissociation inhibitor beta 0 8917100.0 2269500.0 1593900.0 5053700.0 False True 2197455.9647614905 2230352.5820786916 3729984.3622497832 1.0 1.0149703192440407 1.6974102881076991 21.067402824541883 -6.9116330363302865 0.8845371419202116 0.9799449822800929 1.788756440677955 0.9915231901278843 0.029949431596968966 0.10334890677250773 0.13298278565053936 0.024719538762463907 0.06903473951639459 1.225651394474692e-07 6.9116330363302865 0.8088114583978622 DWNVDLIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DWNVDLIPK 9 0 P31150;G5E9U5;P50395;P50395-2;Q5SX87;Q5SX86;V9GYJ7;V9GYF8;Q5SX90 P31150;P50395 GDI1;GDI2 Rab GDP dissociation inhibitor alpha;Rab GDP dissociation inhibitor beta 0 10257900.0 1311900.0 4014000.0 4932000.0 False True 1796944.882764448 3836648.207477057 3767163.177728426 1.0 2.1350950962806925 2.0964266705459345 20.777114727430853 -10.12636627625819 5.09213650411908 0.9999602894071649 2.1157608834152604 0.9991000031246531 0.01578631870791659 7.117166868762878e-06 1.2210915731608495e-06 0.015285578099678676 0.0050950124535018414 7.475387736422248e-11 10.12636627625819 1.1158005940080955 DWQSYYYHHPQDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DWQSYYYHHPQDR 13 0 Q1KMD3 Q1KMD3 HNRNPUL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 7207100.0 2181200.0 2028400.0 2997500.0 False True 2859574.3227708503 1725770.6266412733 2687347.4540503263 1.0 0.6035061277823506 0.9397718508838613 21.447368972224872 -10.080800641643787 7.201212014044633 1.0000000548621084 0.7716389893331059 0.38077364448538686 0.13727990659778658 1.208350767189008e-07 1.540264706046291e-08 0.13292072969619265 0.04430689933517808 8.302317893068755e-11 10.080800641643787 -0.22836106552900248 DWQSYYYHHPQDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DWQSYYYHHPQDR 13 0 Q1KMD3 Q1KMD3 HNRNPUL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 7861600.0 2181200.0 2971400.0 2709000.0 False True 2987648.5847136355 2840113.722894201 2069189.9936063082 1.0 0.9506184018514428 0.6925814515781276 21.510579033747764 -6.938826801943452 0.6703902533269955 1.0029635033222724 0.6253349546301273 0.9980061399519278 0.006018962587242011 0.0883060224638411 0.05707799195270826 0.005808173780861762 0.02232598352730856 1.1512594234209132e-07 6.938826801943452 -0.377628548692145 DWVLNEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DWVLNEFK 8 0 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 5528060.0 2250900.0 918460.0 2358700.0 False True 2179446.411580366 1285205.8677056246 1740885.71051676 1.0 0.5896937226245873 0.798774267294053 21.05553030033991 -10.502231748464501 7.315398793574327 1.0000698252819544 0.6942339949593328 0.7403682064459258 0.0853567749305627 9.722827701377734e-05 6.615771147355205e-06 0.08266510035641084 0.02754878064933702 3.1460690589665785e-11 10.502231748464501 -0.3058358303226216 DWVLNEFK(ub)HGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DWVLNEFKHGK 11 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 51607300.0 5232500.0 6280800.0 40094000.0 True False 7938085.046990132 5159942.167885615 32169403.326175507 1.0 0.6500235431267015 4.052539514976993 22.920359588478956 -6.881534724566663 1.0712533101836967 0.7783862757557355 4.3008350264567 0.974900324319893 0.24210531262631307 0.12627700631111 0.2641720766180371 0.1738534239197157 0.4220921053509122 1.3136064596888196e-07 6.881534724566663 3.5224487507009647 up DWYDVK(ub)APAMFNIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DWYDVKAPAMFNIR 14 1 P61247;D6RG13;H0Y9Y4;E9PFI5;H0Y8L7;D6RI02 P61247 RPS3A 40S ribosomal protein S3a 1 6429380.0 1158000.0 2322300.0 2949080.0 True False 1518149.214087951 1975821.8922544983 2643937.4911728934 1.0 1.3014675197401466 1.7415531139086846 20.533882164982195 -6.9657049695399245 0.34574573916171203 0.9553343217051644 2.10243981318412 0.9999269419976171 0.0026026398741479584 0.07772260855427414 0.01402136308155473 0.006109408874674797 0.037935742123482954 1.0821688543800977e-07 6.9657049695399245 1.1471054914789556 DWYDVK(ub)APAMFNIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DWYDVKAPAMFNIR 14 1 P61247;D6RG13;H0Y9Y4;E9PFI5;H0Y8L7;D6RI02 P61247 RPS3A 40S ribosomal protein S3a 1 25799800.0 10237900.0 8722400.0 6839500.0 True False 9912903.468443133 12205299.806715097 5048029.769398136 1.0 1.2312537739895892 0.5092382656068527 23.240876250955534 -6.820530425014261 1.3696596095768372 1.124574930327936 0.49330551571924564 0.8855894770716701 0.10182602726725055 0.19278739003747508 0.7105161028402281 0.058420817655920484 0.13462646227801014 1.511713790751163e-07 6.820530425014261 -0.6312694146086903 DWYDVK(ub)APAMFNIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DWYDVKAPAMFNIR 14 1 P61247;D6RG13;H0Y9Y4;E9PFI5;H0Y8L7;D6RI02 P61247 RPS3A 40S ribosomal protein S3a 1 9015800.0 1158000.0 3115500.0 4742300.0 True False 1586143.8937733283 2977846.908419224 3622266.410734288 1.0 1.8774128375800312 2.283693443548279 20.597092226505087 -9.843596900390693 0.1934387425363683 3.1009662639722774e-13 2.680031350951728 0.9994790557642811 0.012226961184213321 1.3260028902551728 0.08536322081487072 0.9679038628860592 0.25233518174892194 1.4335178318720638e-10 9.843596900390693 2.680031350951418 DWYDVK(ub)APAMFNIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DWYDVKAPAMFNIR 14 1 P61247;D6RG13;H0Y9Y4;E9PFI5;H0Y8L7;D6RI02 P61247 RPS3A 40S ribosomal protein S3a 1 25675600.0 10237900.0 10644200.0 4793500.0 True False 8513267.465871047 10586857.58189171 5795798.687360174 1.0 1.2435715927325797 0.6807960293265811 23.02128152638981 -6.789081906923101 1.500042674239236 1.1362936382575586 0.6749639933996151 0.7983315393138555 0.10348609192185551 0.23671776123821292 1.052283303285562 0.054305737921117585 0.1272262086052796 1.625242209966513e-07 6.789081906923101 -0.4613296448579435 DWYPHSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DWYPHSR 7 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 20033600.0 3580800.0 8905200.0 7547600.0 False True 4694463.476516526 7576578.872197728 6766646.7536915 1.0 1.6139392520782465 1.4414100328058392 22.16252885308199 -10.068756435538267 4.441973621200921 0.9999620005185142 1.5276746424746215 0.9257735165292187 0.07043475896299588 10371363.714155043 7836362.931571028 3439.8336454721384 0.024111691556249072 8.535786905489648e-11 10.068756435538267 0.5277126419561072 DWYPHSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DWYPHSR 7 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 21180300.0 5903100.0 3617200.0 11660000.0 False True 5715709.32169358 5061566.823448805 8605896.207497971 1.0 0.885553574993392 1.5056567300990775 22.446501117875734 -6.8590494212854844 1.1904566698488985 0.9380508277150896 1.535154163817317 0.9524762135917799 0.05873479465301748 0.14779209508600405 0.39852332695046977 0.03849420205345974 0.08976731582051294 1.3834089426205867e-07 6.8590494212854844 0.5971033361022273 DWYPHSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DWYPHSR 7 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 70241800.0 9293400.0 53359000.0 7589400.0 False True 14098767.238547182 43836669.554230094 6089351.763447818 1.0 3.1092554981954064 0.4319066809471847 23.749065686652195 -6.6966174699435586 1.842740770039395 2.314023600298594 0.4402752050863863 0.40173140918951367 0.8908958320132879 0.40254067234574753 2.6549803577927436 0.38603351541318537 0.9970133434255194 2.0108632172208532e-07 6.6966174699435586 -1.8737483952122078 DWYPHSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DWYPHSR 7 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 23325800.0 3580800.0 9981500.0 9763500.0 False True 4904718.527481465 9540484.325593488 7457562.385594385 1.0 1.9451644925468239 1.5204873314970402 22.225738914604882 -10.138929109814454 4.56529073632279 0.9999302309103788 1.7328259118491767 0.798804617615966 0.17337372529893041 121148252.6793617 18.628060667170924 109383.68566025457 0.05935043759297761 7.26224489881394e-11 10.138929109814454 0.7328956809387979 DWYPHSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DWYPHSR 7 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 9979550.0 5903100.0 3927400.0 149050.0 False True 4908689.201670597 3906242.3166721365 180215.66587066493 1.0 0.7957811456758571 0.0367136028513134 22.22690639331001 -7.223506296535111 0.7877561558696653 0.9927048253877263 1.9834535014521688e-22 0.9927302056338209 0.03533603341545771 0.0928372662132576 0.10755762778963111 0.030757875990271452 0.06332454288107299 5.977143787787892e-08 7.223506296535111 -0.9927048253877263 down DWYPHSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DWYPHSR 7 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 26777100.0 9293400.0 8999000.0 8484700.0 False True 12030489.500301315 8498197.73924323 6940571.660373836 1.0 0.706388359262554 0.5769151504766288 23.520192008744644 -13.999999999999998 0.11110695032109509 2.41406221423614 0.3431420493454163 0.9997374434203959 0.0028680864114018767 12.006251834400608 0.10132776529017636 3.8008329046363123 0.20758560415486565 1.0000000000000041e-14 13.999999999999998 -2.0709201648907234 DYAAQTSPSPK(ub)AGAATGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYAAQTSPSPKAGAATGR 18 1 P06576;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial 1 4162370.0 766770.0 1030300.0 2365300.0 True False 1005242.8954112438 876583.2560779452 2120561.445559714 1.0 0.8720113915546113 2.1095015495654854 19.93911270920163 -6.88138291169457 1.0720991450483088 0.9191355317383597 2.1995459167393343 0.9747821105502192 0.08823855170118615 0.12641021222489335 0.2649667003622277 0.06332201825433367 0.15367570626570973 1.314065726930438e-07 6.88138291169457 1.2804103850009745 up DYAAQTSPSPK(ub)AGAATGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYAAQTSPSPKAGAATGR 18 1 P06576;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial 1 6464300.0 1299600.0 1523100.0 3641600.0 True False 1258344.9093650754 2131281.772861569 2687755.7143417276 1.0 1.69371827787419 2.135945156481693 20.263095985046114 -8.625822661961939 0.133768380386541 1.6428501667770703e-25 3.0807533615436644 0.999923903917126 0.004078323089129945 0.2187586781622947 0.03600993804149912 0.420710345894037 0.3422214707203883 2.3668859847603208e-09 8.625822661961939 3.0807533615436644 DYAAQTSPSPK(ub)AGAATGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYAAQTSPSPKAGAATGR 18 1 P06576;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial 1 3686060.0 766770.0 979890.0 1939400.0 True False 1050265.5901801183 936595.2197370939 1481353.663196779 1.0 0.8917698803942247 1.4104562474932936 20.002322770724522 -6.852241877717049 1.2241625287275242 0.9421126253632787 1.432112733685199 0.9435125063205174 0.05309898208922042 0.1550078299856073 0.4458696437591224 0.033920196872041807 0.07861710333561354 1.4052646523897406e-07 6.852241877717049 0.4900001083219204 DYAAQTSPSPK(ub)AGAATGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYAAQTSPSPKAGAATGR 18 1 P06576;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial 1 6988700.0 1299600.0 2780300.0 2908800.0 True False 1080674.982041827 2765321.97205366 3517016.631228382 1.0 2.5588840474763854 3.2544628955722947 20.04350126048039 -9.32429194129567 0.2535413109014882 3.9561946071758166e-13 3.685305112675133 0.9990746043610683 0.028674367911269757 0.7361928597674512 0.09630934340825523 0.9143752435522943 0.2956084328323188 4.739232975928948e-10 9.32429194129567 3.685305112674737 DYAFIHFDER ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYAFIHFDER 10 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 17417200.0 5805000.0 4308500.0 7303700.0 False True 7610411.215699971 3665688.5944014653 6547983.1860374855 1.0 0.4816676117105601 0.8603980784283063 22.85954297874589 -9.864278105004926 6.994222993836233 1.0000000037467984 0.6710328450694333 0.5014870785159211 0.15461606558411314 8.932893796290605e-09 1.594743750550642e-09 0.1497063639966387 0.04990212058861351 1.366853266531776e-10 9.864278105004926 -0.32896715867736515 DYAFIHFDER ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYAFIHFDER 10 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 16863130.0 5894100.0 3020930.0 7948100.0 False True 5706995.021767227 4227203.102941836 5866254.172111032 1.0 0.7407055879352846 1.0279059557151127 22.44429987387089 -6.668858938715647 1.9413595598958455 0.834337906401236 1.0267430931732708 0.27415275875288747 0.11017026536159066 0.46366277561036817 3.36787516566978 0.04570361660958201 0.12229318179783497 2.1435867370584073e-07 6.668858938715647 0.1924051867720349 DYAFIHFDER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYAFIHFDER 10 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 16980520.0 5805000.0 5183120.0 5992400.0 False True 7951265.374226408 4954112.620114225 4577118.537351945 1.0 0.6230596498731774 0.5756465571113278 22.92275304026878 -13.999999999999998 0.29234243213393446 4.291345794829153 0.5630285725172834 0.9996327054965298 0.0036385731161831334 16.106461805125154 0.17151442495677338 31.925262004738997 0.01771932453431039 1.0000000000000041e-14 13.999999999999998 -3.72831722231187 DYAFIHFDER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYAFIHFDER 10 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 10377000.0 5894100.0 2072300.0 2410600.0 False True 4901205.302902993 2061136.1085806547 2914645.3146449164 1.0 0.42053657849424103 0.5946792950947325 22.224705149305166 -10.355991435194657 4.97390708779938 1.0003083701122726 0.5076079367943789 0.9142354405132408 0.07109346634926825 0.00024325834402165385 3.149632013186134e-05 0.06887819075396993 0.02294531759951779 4.405635518597632e-11 10.355991435194657 -0.4927004333178937 DYAFIHFDER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYAFIHFDER 10 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 16867900.0 2763900.0 9497500.0 4606500.0 False True 3577923.034614112 8968955.776026532 3768164.26668145 1.0 2.5067492199406285 1.0531708564513198 21.770690922959158 -6.637799793522298 2.0526431470588244 1.9869682775922937 1.0592048378576002 0.1461962388180691 0.6450488513012343 0.5388891624480436 4.336802398612042 0.25616845036885705 0.7141900978811195 2.3025030092948596e-07 6.637799793522298 -0.9277634397346934 DYAFVHFEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYAFVHFEDR 10 0 O43390;O43390-3;B4DT28;A0A286YEZ8;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 12360300.0 6066900.0 6293400.0 0.0 False True 7953764.65194317 5354449.251481068 0.0 1.0 0.6731968427269133 0.0 22.923206443448972 -7.483872699928271 0.7221511761102957 0.9926002140588641 3.856651778566585e-17 0.98712015349198 0.047249323036569355 0.11828987906851048 0.1417551684418733 0.041581244659565905 0.0751977852140957 3.281914782547144e-08 7.483872699928271 -0.9926002140588641 down DYAFVHFEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYAFVHFEDR 10 0 O43390;O43390-3;B4DT28;A0A286YEZ8;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 2014000.0 0.0 2014000.0 0.0 False True 0.0 2818200.7028712514 0.0 0.0 DYAFVHFEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYAFVHFEDR 10 0 O43390;O43390-3;B4DT28;A0A286YEZ8;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 16945500.0 6066900.0 4727400.0 6151200.0 False True 8309996.881807777 4518527.8365787305 4698413.247940608 1.0 0.5437460327416824 0.5653929014373473 22.986416504971864 -10.081814394349339 5.083717734993287 1.0000095715778459 0.5545694670881636 0.9982318338837286 0.008837297143647215 9.587195029454337e-07 1.7316623640971191e-07 0.008556859916517194 0.0028522253878885077 8.282960792982728e-11 10.081814394349339 -0.4454401044896823 DYAFVHFEDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYAFVHFEDR 10 0 O43390;O43390-3;B4DT28;A0A286YEZ8;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 4238000.0 0.0 2106500.0 2131500.0 False True 0.0 2095151.8663924886 2577186.795057514 0.0 DYAFVHMEK(ub)EADAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYAFVHMEKEADAK 14 1 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 1 13016700.0 5904900.0 3699000.0 3412800.0 True False 7741381.08313295 3147123.6185890655 3059676.1938892305 1.0 0.40653257923784053 0.39523647796588957 22.88415953931716 DYAFVHMEK(ub)EADAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYAFVHMEKEADAK 14 1 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 1 13130500.0 3913400.0 4459200.0 4757900.0 True False 3789171.259086858 6239781.814420803 3511663.2560595647 1.0 1.6467405107270108 0.9267628766153554 21.8534509160992 -6.669962893765399 1.9373362343891172 1.4128239222444285 0.9296646718042346 0.27892383868984416 0.27472353270701233 0.461222499960272 3.33730380442605 0.11415750925937214 0.3050337016864139 2.1381447653485167e-07 6.669962893765399 -0.4831592504401939 DYAFVHMEK(ub)EADAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYAFVHMEKEADAK 14 1 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 1 42218400.0 6858400.0 10454000.0 24906000.0 True False 10404694.216202017 8588402.02252519 19983318.183312424 1.0 0.8254353125680015 1.9206060041817214 23.310731230510022 -6.86609249483532 1.1544950477907974 0.9032508957426457 1.9801748947654683 0.9606291716030777 0.09532893363919213 0.1406604371580974 0.35284658353906356 0.06422039129544425 0.1511027430126011 1.3611547566249554e-07 6.86609249483532 1.0769239990228225 DYAFVHMEK(ub)EADAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYAFVHMEKEADAK 14 1 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 1 12253100.0 3913400.0 4478000.0 3861700.0 True False 3254165.493015144 4453876.125186595 4669163.615516585 1.0 1.3686692132734344 1.4348267245592283 21.633856191533475 -12.246235882246012 0.27246469075347074 1.1262354229165138e-12 1.4579079515643976 0.9994439529079121 0.004511021888897954 5.921492783175546 0.15641686167530003 3.32600487995124 0.027121746725605262 5.672364335289013e-13 12.246235882246012 1.4579079515632714 DYAFVHMEK(ub)EADAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYAFVHMEKEADAK 14 1 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 1 60596400.0 6858400.0 12263000.0 41475000.0 True False 8878333.999275442 11580553.269956646 33926975.56943733 1.0 1.3043610739246498 3.821322285488032 23.08185755260247 -6.92948418023429 0.7510149959836709 0.960983563328625 4.331317493733448 0.9964358944586551 0.07548280512139767 0.09290648171172794 0.07899897089058865 0.06855872868994435 0.2283908371794079 1.176293832003039e-07 6.92948418023429 3.370333930404823 up DYALEK(ub)EK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYALEKEK 8 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 19963000.0 5875500.0 5974800.0 8112700.0 True False 7702837.398422939 5083383.129587986 7273275.626513456 1.0 0.6599364450596796 0.9442333065478663 22.876958540664862 -10.033939951850241 6.760091050355107 1.000000058321018 0.8020848758037725 0.3925324993772381 0.1160637076867953 1.0196993964114143e-07 1.461510416073231e-08 0.11237823523373845 0.03745940058083678 9.248260370717133e-11 10.033939951850241 -0.1979151825172455 DYALEK(ub)EK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYALEKEK 8 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 28351400.0 4508700.0 6363700.0 17479000.0 True False 4365573.786437608 8904758.596257098 12900725.541239882 1.0 2.039768202732304 2.9551042250890736 22.057739855354164 -6.972624629771154 0.18504736478404843 0.338017134738665 4.6817338271819855 0.9999962770337887 0.0015410927856057723 0.07545988247015005 0.005869407823093928 0.0337227236036159 0.10119256023616036 1.0650631779323704e-07 6.972624629771154 4.34371669244332 DYALEK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYALEKEK 8 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 171998600.0 8752600.0 15706000.0 147540000.0 True False 13278334.100771286 12903141.588461904 118378654.3309208 1.0 0.9717440072329865 8.915173652999487 23.662570821791416 -6.906098495218098 0.9218984788837682 0.7226920866488645 9.860452766521826 0.9893639875234276 0.3854962608549585 0.10705472566551032 0.1531819827161485 0.3096449843968394 0.8333252334071446 1.2413707406996391e-07 6.906098495218098 9.137760679872962 up DYALEK(ub)EK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYALEKEK 8 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 19396800.0 5875500.0 5214000.0 8307300.0 True False 8047831.129417269 4983628.239607718 6345286.834213988 1.0 0.6192510950423701 0.7884468165615499 22.940168602187754 -10.098109163583564 5.104731226301181 1.0000073722990543 0.7038489558012829 0.803341149305895 0.06907386406636094 5.795696086481005e-06 1.023837262144526e-06 0.06688214612267837 0.02229349376526275 7.977941297750533e-11 10.098109163583564 -0.2961584164977714 DYALEK(ub)EK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYALEKEK 8 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 31958700.0 4508700.0 11478000.0 15972000.0 True False 3749183.8192766896 11416165.73579539 19311671.353815928 1.0 3.0449735958792896 5.1509001117852975 21.83814513078844 -6.970757344558145 0.23940796701683492 0.23824783111733758 8.01849201019568 0.9999877017583959 0.005942970436447691 0.07605772369739762 0.008145785350128033 0.05055123201230517 0.2055233583322386 1.0696523642924627e-07 6.970757344558145 7.780244179078341 DYALEK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYALEKEK 8 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 253902600.0 8752600.0 8970000.0 236180000.0 True False 11330413.239539579 8470811.614736293 193197663.41144574 1.0 0.747617181796673 17.05124599844661 23.433697143883865 -6.903386222237289 0.9396249744471623 0.3836890900607849 18.885232734951764 0.988176706225902 0.8293013003055785 0.10895495158027685 0.16370092887295568 0.6574985423928502 1.741649075892925 1.2491476571525585e-07 6.903386222237289 18.50154364489098 up DYALHWLVLGTHTSDEQNHLVVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYALHWLVLGTHTSDEQNHLVVAR 24 0 Q16576;E9PC52;Q16576-2;C9J7L0 Q16576 RBBP7 Histone-binding protein RBBP7 0 91660000.0 29206000.0 20851000.0 41603000.0 False True 28278871.51655615 29176913.036528543 30705926.23675277 1.0 1.0317566250635788 1.0858257274791066 24.753221213992795 -6.963066567679455 0.38981391615135813 0.9966723804187934 1.1228521495141248 0.999867549081556 0.0004077214989501159 0.07862334568214968 0.017212531485283407 0.0006981665613675653 0.004548556126929291 1.088763197373798e-07 6.963066567679455 0.12617976909533146 DYALHWLVLGTHTSDEQNHLVVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYALHWLVLGTHTSDEQNHLVVAR 24 0 Q16576;E9PC52;Q16576-2;C9J7L0 Q16576 RBBP7 Histone-binding protein RBBP7 0 313101000.0 85681000.0 119610000.0 107810000.0 False True 129984341.12014548 98264660.98280443 86501306.24519841 1.0 0.7559730667248425 0.6654748218113797 26.953762595052655 -13.999999999986741 0.13778743656253023 2.1635991515315403 0.55043592011464 0.9996118991647062 0.0027832939971300127 11.932452468314752 0.1161332289328447 3.738069098927705 0.10269851574882445 1.0000000000305294e-14 13.999999999986741 -1.6131632314169002 DYALHWLVLGTHTSDEQNHLVVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYALHWLVLGTHTSDEQNHLVVAR 24 0 Q16576;E9PC52;Q16576-2;C9J7L0 Q16576 RBBP7 Histone-binding protein RBBP7 0 51602000.0 11684000.0 11739000.0 28179000.0 False True 16003890.548227603 11220332.164318193 21523700.564722084 1.0 0.7011002812413524 1.3449042593649698 23.93191933134503 -6.7804474900830325 1.5339600731800112 0.8308533937186519 1.3500905083494232 0.769015576195047 0.12642665846733192 0.24988528849301228 1.1613931886046556 0.06491028036326398 0.15311450891516068 1.6578777763326143e-07 6.7804474900830325 0.5192371146307714 DYALHWLVLGTHTSDEQNHLVVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYALHWLVLGTHTSDEQNHLVVAR 24 0 Q16576;E9PC52;Q16576-2;C9J7L0 Q16576 RBBP7 Histone-binding protein RBBP7 0 62664000.0 29206000.0 13411000.0 20047000.0 False True 24286083.045178194 13338752.281124925 24238735.013144717 1.0 0.54923440129524 0.9980504047546326 24.53362648942707 -10.91866073031322 10.910810021520723 1.0293303834522485 0.7736424030269098 0.25325783587913486 0.18322836614512025 0.09577093684771058 0.0007139639775613374 0.1299698485058416 0.05913670088607045 1.2059776790168372e-11 10.91866073031322 -0.2556879804253387 DYALHWLVLGTHTSDEQNHLVVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYALHWLVLGTHTSDEQNHLVVAR 24 0 Q16576;E9PC52;Q16576-2;C9J7L0 Q16576 RBBP7 Histone-binding protein RBBP7 0 279357000.0 85681000.0 122020000.0 71656000.0 False True 110915743.52500874 115229479.73579946 58615343.25264859 1.0 1.0388920100401986 0.5284672976964022 26.724888917145105 -6.88852062446517 1.0311213564300055 1.0284064003413498 0.4858220126925175 0.9799333918333917 0.0328634299770489 0.12035056336726488 0.2289382360432161 0.024330826641144207 0.06034141084416321 1.2926453121583287e-07 6.88852062446517 -0.5425843876488323 DYDDMSPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYDDMSPR 8 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 6231260.0 1874700.0 396060.0 3960500.0 False True 1815188.6746588985 554208.823425615 2923126.2375467983 1.0 0.30531747534716147 1.6103704691172658 20.791688082199588 -6.762135339727015 1.6048298086697943 0.5975559731360354 1.6155810962670518 0.6994749110839997 0.29227709554384657 0.27934466645698985 1.4184858834353191 0.1436763339319943 0.34449792725862566 1.7292773783877067e-07 6.762135339727015 1.0180251231310165 DYEK(ub)YLANIEQQHGNSGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYEKYLANIEQQHGNSGR 18 1 Q9UKX7;Q9UKX7-2 Q9UKX7 NUP50 Nuclear pore complex protein Nup50 1 7511600.0 2423900.0 2164000.0 2923700.0 True False 2346954.6212757793 3028096.48511092 2157895.2608800856 1.0 1.2902237042252138 0.9194448164093931 21.162358516727096 -6.697940145311261 1.8385686540310904 1.1805854241453446 0.9206028239910946 0.4076296535656252 0.12255452116118379 0.39983181524339073 2.626260549696514 0.05321156079964918 0.13717716871920538 2.0047483037681853e-07 6.697940145311261 -0.25998260015425 DYEK(ub)YLANIEQQHGNSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYEKYLANIEQQHGNSGR 18 1 Q9UKX7;Q9UKX7-2 Q9UKX7 NUP50 Nuclear pore complex protein Nup50 1 6004400.0 1678400.0 2149600.0 2176400.0 True False 2298949.83705454 2054623.564223389 1662379.1443649945 1.0 0.8937226602803188 0.7231037048180519 21.132543556205757 -6.964104158316399 0.3731108413956249 1.0126666157552948 0.5981916455860031 0.9998934643314522 0.001177219139003578 0.07826631266388737 0.01594015052792502 0.0022388152351082292 0.014466774374224943 1.0861650937235405e-07 6.964104158316399 -0.4144749701692917 DYENDEDVNK(ub)QLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYENDEDVNKQLDK 14 1 O43617;A6NKE1;A0A087WWM0 O43617 TRAPPC3 Trafficking protein particle complex subunit 3 1 7427640.0 3409640.0 2154600.0 1863400.0 True False 4470071.059000734 1833142.0785650192 1670593.2429949578 1.0 0.41009237982333335 0.37372856514912134 22.091866334883356 -13.912290317438574 0.39690204756423975 9.999629725992945 0.3714109367799798 0.9998318316374969 0.0037223268956696203 24.455066662081 0.2070588431228664 188.80511913586835 0.009388802006220854 1.2237978406445922e-14 13.912290317438574 -9.628218789212966 DYENDEDVNK(ub)QLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYENDEDVNKQLDK 14 1 O43617;A6NKE1;A0A087WWM0 O43617 TRAPPC3 Trafficking protein particle complex subunit 3 1 7532600.0 2300900.0 2525900.0 2705800.0 True False 2227859.1889489847 3534505.0423944863 1997069.807739963 1.0 1.5865028902755407 0.8964075546812728 21.087226619854544 -6.681518451816814 1.8965092164340296 1.3705650999937642 0.8989977711278819 0.33122308043569204 0.24848859794214462 0.43507466156235636 3.02679176674476 0.10508601464770194 0.2766176018593782 2.0820039454926174e-07 6.681518451816814 -0.47156732886588226 DYENDEDVNK(ub)QLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYENDEDVNKQLDK 14 1 O43617;A6NKE1;A0A087WWM0 O43617 TRAPPC3 Trafficking protein particle complex subunit 3 1 8578780.0 3409640.0 2186540.0 2982600.0 True False 4670276.05005639 2089931.432879143 2278171.3085751836 1.0 0.44749633864874183 0.4878022806698281 22.155076396406248 -10.044101282363144 6.349879061546076 1.000000453269708 0.4676493114335397 0.9957190452299846 0.016454831925666893 1.0559744712216732e-07 1.5889982310406433e-08 0.01593233603484392 0.005310774167725845 9.034387570620393e-11 10.044101282363144 -0.5323511418361683 DYENDEDVNK(ub)QLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYENDEDVNKQLDK 14 1 O43617;A6NKE1;A0A087WWM0 O43617 TRAPPC3 Trafficking protein particle complex subunit 3 1 9472680.0 2300900.0 4716300.0 2455480.0 True False 1913300.2971529998 4690892.355787743 2968909.515143243 1.0 2.4517282325037075 1.5517216610278037 20.86763189528882 -10.131584639818069 5.846358251543125 0.9999916115874594 2.0017249467657954 0.6228905650912193 0.3674261442114215 4.017428432443593e-05 5.966553575625382e-06 0.3557618090480429 0.11858627812431605 7.386103009209809e-11 10.131584639818069 1.001733335178336 DYEQPTCAK(ub)VENAQFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYEQPTCAKVENAQFK 16 1 Q9UK61-3;Q9UK61-4;Q9UK61;Q9UK61-2;A0A087X0F1 Q9UK61-3 FAM208A Protein FAM208A 1 3187100.0 1037500.0 708000.0 1441600.0 True False 862727.2190430855 704185.8634730036 1743031.8947947046 1.0 0.8162323477565344 2.0203742925000445 19.718544948159916 -6.867986942122168 1.1447628988672103 0.8972414856170677 2.0882272675571976 0.9626286658903833 0.10239280836619308 0.1387958220170245 0.34121877339824364 0.0695003464748281 0.1639855388887214 1.355230159274048e-07 6.867986942122168 1.19098578194013 up DYETAK(ub)NYFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYETAKNYFK 10 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 4678000.0 1029500.0 1984100.0 1664400.0 True False 856074.8645829955 1973411.2594869863 2012418.3446838958 1.0 2.3051853770385593 2.3507504167455835 19.707377441670523 -10.787399929335354 0.6053732025449348 5.140927507017067e-19 2.3451447279909057 0.9998930955196927 0.006475461887544186 2.417058862745529 0.29817202844122903 3.5202157176440876 0.00786520686345543 1.631548809386713e-11 10.787399929335354 2.3451447279909057 DYFEEYGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYFEEYGK 8 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 79454000.0 2554000.0 46567000.0 30333000.0 False True 3348318.7329711854 39619385.11674432 27194432.134681795 1.0 11.832620570619156 8.121817038173774 21.675005436695685 -9.557706368820055 7.592391732536594 0.9999993972575859 9.977218804411544 0.8864081191897988 1.5149291983735935 0.0 0.0 1.4668238889936107 0.4889412963312035 2.7688130370421987e-10 9.557706368820055 8.977219407153958 DYFEEYGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYFEEYGK 8 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 70095000.0 19635000.0 5223000.0 45237000.0 False True 19011697.6726556 7308571.137585186 33388072.61908963 1.0 0.38442496106473734 1.7561857543690838 24.18038402915775 -6.784700378080296 1.5173879506015204 0.6535743280656463 1.7687311455962111 0.7837255364540499 0.26089429238836875 0.24333729884438624 1.1068440751908948 0.13537788324902014 0.31822624836742797 1.6417220147556107e-07 6.784700378080296 1.1151568175305648 DYFEEYGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYFEEYGK 8 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 72587000.0 2554000.0 36016000.0 34017000.0 False True 3498282.819254824 34424694.031014875 25982885.202106204 1.0 9.840454820158808 7.427325503556876 21.738215498218576 -10.112492774879433 9.859159909732925 0.9999999864273048 8.633890161857842 0.9302819493607106 0.9851559181709687 2.9235857146237566e-07 2.8833728544004883e-08 0.9538731161233694 0.3179577053744866 7.718043555665688e-11 10.112492774879433 7.633890175430537 DYFEEYGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYFEEYGK 8 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 22915200.0 19635000.0 1947900.0 1332300.0 False True 16327372.47798649 1937406.2760721226 1610877.7701408062 1.0 0.11866001579153326 0.09866117602894679 23.960789304592026 DYFEEYGK(ub)IDTIEIITDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYFEEYGKIDTIEIITDR 18 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 8859300.0 4621500.0 2947200.0 1290600.0 True False 3842982.0171639756 2931322.848626602 1560458.4929398205 1.0 0.7627729808607964 0.4060540710235745 21.873794794798776 -6.965216252480292 0.3543219478361827 1.0328027742752242 0.1239069711810814 0.9999175328408053 0.0022167687716742597 0.07788766570118819 0.014601664518717227 0.004845340400571995 0.03057510628674277 1.0833873180925056e-07 6.965216252480292 -0.9088958030941428 down DYFEK(ub)YGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYFEKYGK 8 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 15140000.0 6910600.0 5284100.0 2945300.0 True False 9059863.522345604 4495732.877260471 2640548.6093125693 1.0 0.4962252318892021 0.29145567179900844 23.111057887021932 -13.555316623088595 0.12965028962059005 3.1434432406848587 2.7165414636793493e-18 0.9996608913068336 0.00548255048658548 10.218904226178 0.10766282364684139 5.72180909293982 0.25238394606909786 2.7840906827775485e-14 13.555316623088595 -3.1434432406848587 DYFEK(ub)YGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYFEKYGK 8 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 94705000.0 13946000.0 29569000.0 51190000.0 True False 18053371.916758325 27923459.15676004 41873945.25375522 1.0 1.5467171055640665 2.3194528671336503 24.10576498571513 -6.966226494282066 0.33633801808260866 0.9125493395330653 2.979159024319685 0.9999362410990567 0.0043221701445284545 0.07754718346920811 0.01340576997551546 0.011034807636799438 0.06706641968862838 1.0808701063557925e-07 6.966226494282066 2.06660968478662 DYFEQYGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYFEQYGK 8 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;F8VYN5;P09651-2;A0A2R8Y4L2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 70954600.0 3002600.0 28305000.0 39647000.0 False True 3936437.677219766 24082004.33202585 35544708.760878526 1.0 6.117715128932138 9.02966379134525 21.908459206579014 -8.439567209613179 0.3566417152518272 1.0766964740064701e-16 10.057868934125809 0.9977806986580846 0.156359538640797 0.1601338963859719 0.10274079730334015 0.8965195691542532 0.7924707665593113 3.6344005571778953e-09 8.439567209613179 10.057868934125809 DYFEQYGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYFEQYGK 8 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;F8VYN5;P09651-2;A0A2R8Y4L2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 62807400.0 20485000.0 5676400.0 36646000.0 False True 19834714.887922063 7943016.122034943 27047313.243565176 1.0 0.40046031248332575 1.3636350911217319 24.241524323971653 -6.738378571906885 1.6924936446383383 0.6425963284590865 1.3640124096955184 0.5976080479202353 0.25191459895597235 0.32080477555270714 1.8037175976735589 0.11777505355424729 0.2895409251516681 1.8265073664387975e-07 6.738378571906885 0.7214160812364319 DYFEQYGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYFEQYGK 8 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;F8VYN5;P09651-2;A0A2R8Y4L2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 86327600.0 3002600.0 47931000.0 35394000.0 False True 4112742.362213992 45813249.93337884 27034666.16231143 1.0 11.139343508188151 6.573391615943089 21.971669268101905 -9.429134633042242 9.794083392117212 1.000356204317938 8.856367562065628 0.7978767937006113 1.8640420656939776 0.0 0.0 1.8048509641396353 0.6016169880465451 3.722762812146613e-10 9.429134633042242 7.856011357747691 DYFEQYGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYFEQYGK 8 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;F8VYN5;P09651-2;A0A2R8Y4L2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 13697200.0 3886200.0 5329200.0 4481800.0 False True 5030762.508454487 5032625.335256705 3666158.387151398 1.0 1.0003702871680162 0.7287480537970551 22.262345654005788 -6.906589665395806 0.918654518275439 1.0093436367156454 0.6960912634527281 0.9895694970908937 0.013068201397795394 0.1067163532192105 0.15132327372991838 0.010521884588637846 0.02840232810487746 1.2399675922475786e-07 6.906589665395806 -0.3132523732629173 DYFFALAHTVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYFFALAHTVR 11 0 P11216 P11216 PYGB Glycogen phosphorylase, brain form 0 8825800.0 2586000.0 3419200.0 2820600.0 False True 3390271.0428596246 2909068.6879372126 2528751.369105707 1.0 0.8580637509983486 0.7458847204655226 21.692969186803214 -6.973774814672618 0.14142317630317064 1.1472192347411108 0.4537998120079239 0.9999988729964779 0.00011023340759817018 0.07509575177666045 0.004288299362055061 0.006247397025824943 0.014516067463117118 1.0622461979836013e-07 6.973774814672618 -0.6934194227331869 DYFFALAHTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYFFALAHTVR 11 0 P11216 P11216 PYGB Glycogen phosphorylase, brain form 0 7907300.0 2586000.0 2365200.0 2956100.0 False True 3542114.0840223064 2260697.6433295314 2257930.0627905517 1.0 0.6382340008547547 0.6374526650554749 21.756179248326106 DYFFALAHTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYFFALAHTVR 11 0 P11216 P11216 PYGB Glycogen phosphorylase, brain form 0 13246600.0 3450300.0 5533000.0 4263300.0 False True 4466481.36558091 5225083.686102106 3487423.1451520706 1.0 1.1698433864220392 0.7807987674652477 22.090707312269807 -6.788066339337026 1.5042547498370917 1.095164930219279 0.7768902569045908 0.7949343536499992 0.07211609187714108 0.23824723036306947 1.0650744743937453 0.037741435874702446 0.08848025892824528 1.6290471734707916e-07 6.788066339337026 -0.3182746733146882 DYFGAHTYELLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYFGAHTYELLAK 13 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 56580500.0 14133500.0 19180500.0 23266500.0 False True 18529155.36900871 16318844.165003428 20859105.768027358 1.0 0.8807117129741284 1.1257450948312329 24.143293783422635 -6.774372377217326 1.558140319089102 0.9319606738085894 1.127342673228445 0.7468428706730104 0.050337884690706575 0.25942440598846883 1.2436109189317373 0.02545804848379673 0.06035046280019971 1.6812319038269277e-07 6.774372377217326 0.19538199941985568 DYFGAHTYELLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYFGAHTYELLAK 13 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 41684100.0 10902600.0 5971000.0 24810500.0 False True 10556502.930781513 8355251.43835365 18311885.7509544 1.0 0.7914790999574988 1.734654541473115 23.33162865421157 -6.848723853058709 1.2412375722858002 0.8888362652544829 1.7714401493161183 0.9384282068339058 0.10037794847517997 0.15886549710571468 0.47164349694985447 0.06330068783654468 0.14636683630467132 1.4166943012923975e-07 6.848723853058709 0.8826038840616354 DYFGAHTYELLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYFGAHTYELLAK 13 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 52090600.0 14133500.0 16134700.0 21822400.0 False True 19359036.893476136 15421815.603682147 16668398.566435704 1.0 0.7966210141827456 0.861013833392344 24.206503844945527 -10.158525034157837 7.0694374403913525 1.0000001926215747 0.8288174237875447 0.9040570865737324 0.026288258360467227 7.98075550404161e-08 9.496355114485355e-09 0.025453525153995467 0.008484498902573944 6.941845854853011e-11 10.158525034157837 -0.17118276883402994 DYFGAHTYELLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYFGAHTYELLAK 13 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 28631400.0 10902600.0 8144100.0 9584700.0 False True 9065994.967073875 8100226.116822711 11588816.455354344 1.0 0.8934734848454396 1.2782729857498178 23.112033929645847 -6.832878983014577 1.3151394414695565 0.9431847640194544 1.2892393294778086 0.9114846337870681 0.048264611456853894 0.17728646801625828 0.5986915505551026 0.02880689291677544 0.0662882016301662 1.4693356537859085e-07 6.832878983014577 0.3460545654583542 DYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSSYNA ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSSYNA 36 1 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 57669100.0 30249000.0 3934100.0 23486000.0 False True 29288762.052465435 5505006.646060474 17334312.035102673 1.0 0.18795627606927415 0.5918417447637916 24.803843880354304 -9.633558084464598 8.761916855426007 1.0000003422063357 0.3898990085008984 0.7526262456953408 0.1648855521378524 0.0 0.0 0.15964974936497522 0.053216583121658396 2.3251014957208688e-10 9.633558084464598 -0.6101013337054373 DYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSSYNA ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYFGAHTYELLAKPGQFIHTNWTGHGGTVSSSSYNA 36 1 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 64023000.0 30249000.0 11632000.0 22142000.0 False True 25153383.75791255 11569336.107228773 26771789.826959196 1.0 0.45995148082569143 1.064341485210217 24.58424915578858 -6.671193087829425 1.934265667581479 0.655623244721657 1.0618522969696012 0.2839334780319751 0.22934130397159 0.45833768274358994 3.30747402672344 0.09544042514508327 0.2544927586092371 2.1320967696972787e-07 6.671193087829425 0.40622905224794414 DYFLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYFLFR 6 0 P61604;B8ZZ54 P61604 HSPE1 10 kDa heat shock protein, mitochondrial 0 4059670.0 775570.0 1122400.0 2161700.0 False True 1016779.7806305635 954942.2950809333 1938028.0204906063 1.0 0.9391830101978609 1.9060450034605565 19.955575816075857 -6.8919115586988715 1.0110333199375716 0.950404819192854 1.9923779778650592 0.9820929223100631 0.059166806818461405 0.11760483547943221 0.21291087667370204 0.04447554469973359 0.11166621170187495 1.282591747691335e-07 6.8919115586988715 1.0419731586722052 DYFLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYFLFR 6 0 P61604;B8ZZ54 P61604 HSPE1 10 kDa heat shock protein, mitochondrial 0 3507070.0 775570.0 1204400.0 1527100.0 False True 1062319.1879911749 1151185.6255818056 1166430.4316117354 1.0 1.0836532358590598 1.0980037307030412 20.01878587759875 -13.999999999999998 0.24801397863367422 0.4240034633931262 1.1038838343237345 0.9995389786019266 0.000927888461328364 13.920481936848772 0.15759503008645065 3.9899005931764884 0.0066967306725255514 1.0000000000000041e-14 13.999999999999998 0.6798803709306083 DYFSK(ub)FGEVVDCTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYFSKFGEVVDCTLK 15 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 39213100.0 10159900.0 8311200.0 20742000.0 True False 15413311.088182535 6828001.424298002 16642334.608458428 1.0 0.442993811338374 1.0797378002198497 23.877673479171193 -6.675566840642297 1.9175808554943676 0.6461857944179316 1.0772414386379197 0.30399319605210107 0.2363040715148702 0.44843979426205116 3.1841012937650115 0.09902171470627534 0.26266132116038277 2.110732315878214e-07 6.675566840642297 0.4310556442199881 DYFSK(ub)FGEVVDCTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYFSKFGEVVDCTLK 15 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 8997200.0 6750900.0 2246300.0 0.0 True False 5613672.465578759 2234198.7360443617 0.0 1.0 0.3979923570076011 0.0 22.42051346037979 -8.289083320690242 0.5360561514128991 1.03297345608853 7.749893052964e-17 0.9919266308735976 0.03693548314030272 0.14818533647074156 0.1765071470034703 0.059438157808150156 0.07129193632401859 5.139450402361279e-09 8.289083320690242 -1.03297345608853 DYFSK(ub)FGEVVDCTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYFSKFGEVVDCTLK 15 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 23111900.0 10159900.0 9378500.0 3573500.0 True False 13152190.831569865 8856578.230635919 2923159.6672063735 1.0 0.6733918587447065 0.2222564821816428 23.648799801263642 -7.303954141778276 0.4062772557427892 1.030132973832161 5.029795820043232e-13 0.9994310561057417 0.007605768567948062 0.10226984872966298 0.03352671943115227 0.01209476034007561 0.05272313711238057 4.966447606225908e-08 7.303954141778276 -1.030132973831658 down DYGNSPLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYGNSPLHR 9 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;A0A087WUW5;K7ELW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 12995230.0 548830.0 7043300.0 5403100.0 False True 719521.444877281 5992467.094568366 4844039.042194938 1.0 8.328406522463581 6.73230669729534 19.456678160647765 -9.85418514957112 9.824396037343357 1.0000176839049097 7.530356609879461 0.9571181871979979 0.6516050251145926 0.0 2.5740525273713846e-17 0.6309138808108778 0.21030461753577612 1.3989907739770648e-10 9.85418514957112 6.530338925974551 DYGNSPLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYGNSPLHR 9 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;A0A087WUW5;K7ELW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 12482200.0 4171900.0 1448300.0 6862000.0 False True 4039465.318082605 2026613.7427847236 5064636.344412603 1.0 0.5017034639987173 1.2537887927248281 21.94573291329127 -6.728020151698028 1.7300988783860385 0.6994787124102326 1.2532125943233325 0.5502473901208653 0.20950628362885088 0.33994764708734215 1.9924729202442446 0.09599229640831802 0.23876599339065013 1.8705953408585887e-07 6.728020151698028 0.5537338819130999 DYGNSPLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYGNSPLHR 9 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;A0A087WUW5;K7ELW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 13073930.0 548830.0 6534000.0 5991100.0 False True 751747.2825730717 6245306.27495145 4576125.570577611 1.0 8.30772045304253 6.087319072061695 19.519888222170657 -9.660204879432944 8.278643370251029 1.0000000010399246 7.197519764570194 0.9121845165553792 0.906475067929072 0.0 0.0 0.8776907104603625 0.29256357015345413 2.1867297857151783e-10 9.660204879432944 6.197519763530269 DYGVLLEGSGLALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYGVLLEGSGLALR 14 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 21027400.0 6545400.0 7878900.0 6603100.0 False True 8581082.785743758 6703398.831711653 5919874.553407751 1.0 0.781183330715372 0.6898750077604164 23.032728271951292 -13.999999999999993 0.11983262128362035 2.043043105685182 0.5438122295318988 0.999693762052517 0.00227715640321032 11.964383789969794 0.10651487325177676 2.9725959598257488 0.1296126201951895 1.0000000000000164e-14 13.999999999999993 -1.499230876153283 DYGVLLEGSGLALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYGVLLEGSGLALR 14 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 43847000.0 13544000.0 12983000.0 17320000.0 False True 13114053.133610778 18167179.60545057 12783372.411137614 1.0 1.3853214883573133 0.9747842471656881 23.644610309499633 -6.660431897315282 1.9711362060064153 1.2479339955664277 0.9764862534794834 0.23754964647398347 0.16404329666447912 0.4834096162716712 3.611008346207044 0.06722302015508261 0.18188432020474207 2.185587019549826e-07 6.660431897315282 -0.27144774208694433 DYGVLLEGSGLALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYGVLLEGSGLALR 14 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 114602000.0 13174000.0 70369000.0 31059000.0 False True 19985921.14840858 57811102.15449347 24920175.0363567 1.0 2.8925913259242892 1.2468864883088473 24.252480732122024 -6.612312213787024 2.144590451554016 2.2624899961618037 1.2528240564877189 0.05764128417865144 0.8154826788248464 0.6064666255495325 5.28873675792928 0.3135931125679806 0.905316222021647 2.4416746046229713e-07 6.612312213787024 -1.0096659396740848 DYGVLLEGSGLALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYGVLLEGSGLALR 14 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 27106100.0 6545400.0 7647700.0 12913000.0 False True 8965411.262784056 7309799.326438039 9863215.351582948 1.0 0.815333408828822 1.1001408705617028 23.095938333474184 -6.731699140401337 1.7170649295734817 0.8890766717321213 1.100022809268778 0.5670602898821628 0.07761989663257456 0.333088314055561 1.9246906795314958 0.0358120361053871 0.08869367443265343 1.8548161112600746e-07 6.731699140401337 0.2109461375366567 DYGVLLEGSGLALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYGVLLEGSGLALR 14 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 32044400.0 13544000.0 7417400.0 11083000.0 False True 11262436.100934511 7377440.99396138 13400404.057997845 1.0 0.6550484218373706 1.189831750245041 23.42501558493391 -6.7325616537029 1.7139816903106673 0.7930012750394759 1.1896591960923528 0.5710414489064256 0.14498263616373425 0.3314664818289265 1.9088379867220502 0.06700263026846501 0.1657766504362104 1.8511360829094974e-07 6.7325616537029 0.3966579210528769 DYGVLLEGSGLALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYGVLLEGSGLALR 14 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 80424000.0 13174000.0 42494000.0 24756000.0 False True 17054002.698363278 40129171.544771865 20250662.018010627 1.0 2.353064688363347 1.1874433454824151 24.023607054214473 -6.609929597684622 2.15403105972134 1.9040233100701098 1.1916047150286682 0.05018270057947438 0.583359373712598 0.6128015166134985 5.3879176072773936 0.22365458790951043 0.6476288252761216 2.455106874228526e-07 6.609929597684622 -0.7124185950414417 DYGVYLEDSGHTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYGVYLEDSGHTLR 14 0 Q13162;H7C3T4 Q13162 PRDX4 Peroxiredoxin-4 0 29432000.0 7658000.0 10154000.0 11620000.0 False True 10489369.54966853 9705362.705212265 8875595.321412073 1.0 0.9252570098952191 0.8461514564230933 23.322424633366012 -6.970407330734397 0.24827559523423712 1.0256429941440233 0.743453675581757 0.9999853761619132 0.0002401492156356017 0.07617082511189839 0.008556426268274513 0.0017851655812908124 0.007603059104058182 1.0705147837769646e-07 6.970407330734397 -0.28218931856226626 DYHGLIHIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYHGLIHIR 9 0 A0A1W2PNW2;A0A1W2PP47;A0A1W2PNY5;A0A1W2PQZ6;A0A1W2PRF0;A0A1W2PRJ0;A0A1W2PPP6;A0A1X7SBS0;A0A1W2PS93;A0A1W2PR08;A0A1W2PRF5;G5E9D4;Q96EB1;Q96EB1-3;Q96EB1-2 A0A1W2PNW2 ELP4 Elongator complex protein 4 0 12032200.0 4021900.0 2669900.0 5340400.0 False True 5272749.848135001 2271561.3271886893 4787826.636734072 1.0 0.43081151061853473 0.9080321984983891 22.330124122761855 -10.152700484727976 7.650477522109252 1.000000108900091 0.6694218545584668 0.3901718632563216 0.19482453000093933 3.6200103033359854e-07 4.0048627745665206e-08 0.18863810468218906 0.06287934667719378 7.035573675580816e-11 10.152700484727976 -0.33057825434162413 DYHGLIHIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYHGLIHIR 9 0 A0A1W2PNW2;A0A1W2PP47;A0A1W2PNY5;A0A1W2PQZ6;A0A1W2PRF0;A0A1W2PRJ0;A0A1W2PPP6;A0A1X7SBS0;A0A1W2PS93;A0A1W2PR08;A0A1W2PRF5;G5E9D4;Q96EB1;Q96EB1-3;Q96EB1-2 A0A1W2PNW2 ELP4 Elongator complex protein 4 0 3682820.0 1000600.0 408020.0 2274200.0 False True 968836.5007007484 570944.5137961904 1678518.795462424 1.0 0.5893094586994119 1.7325098654400102 19.88589369370933 -6.809542371608827 1.4163776417938267 0.7760501018133042 1.7523138531693352 0.8586330467392993 0.17777974839892519 0.20743589903514267 0.8202558381124447 0.09869486963503143 0.22835755330119378 1.5504495109945967e-07 6.809542371608827 0.9762637513560309 DYHGLIHIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYHGLIHIR 9 0 A0A1W2PNW2;A0A1W2PP47;A0A1W2PNY5;A0A1W2PQZ6;A0A1W2PRF0;A0A1W2PRJ0;A0A1W2PPP6;A0A1X7SBS0;A0A1W2PS93;A0A1W2PR08;A0A1W2PRF5;G5E9D4;Q96EB1;Q96EB1-3;Q96EB1-2 A0A1W2PNW2 ELP4 Elongator complex protein 4 0 8039800.0 4021900.0 1800200.0 2217700.0 False True 5508905.117760751 1720661.2115346796 1693924.9349651923 1.0 0.3123417765877388 0.3074884934038827 22.393334184284747 DYHGLIHIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYHGLIHIR 9 0 A0A1W2PNW2;A0A1W2PP47;A0A1W2PNY5;A0A1W2PQZ6;A0A1W2PRF0;A0A1W2PRJ0;A0A1W2PPP6;A0A1X7SBS0;A0A1W2PS93;A0A1W2PR08;A0A1W2PRF5;G5E9D4;Q96EB1;Q96EB1-3;Q96EB1-2 A0A1W2PNW2 ELP4 Elongator complex protein 4 0 3247400.0 1000600.0 1441800.0 805000.0 False True 832043.2340959145 1434032.737225108 973321.7781005381 1.0 1.7235074794921037 1.169797118965981 19.666298969143607 -10.190120811808637 4.238796912860302 0.9998439342778426 1.4466522991501503 0.4645494513184032 0.2260513082485743 79377633.82302535 39.25879529607722 127703.90157804987 0.077383375402782 6.454746462629402e-11 10.190120811808637 0.4468083648723077 DYIAYAHSTIMPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYIAYAHSTIMPR 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 48042000.0 16584600.0 17173200.0 14284200.0 False True 21742571.205494873 14611025.500609303 12806208.007721666 1.0 0.6720008117952831 0.5889923453250657 24.37401922307139 -13.999999999999998 0.1929484424376971 2.7765545129447036 0.531176157766729 0.9994880552588209 0.004015047201970352 12.400244452811235 0.1392990544356111 8.290967082463709 0.055775780800589696 1.0000000000000041e-14 13.999999999999998 -2.2453783551779747 DYIAYAHSTIMPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYIAYAHSTIMPR 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 18170200.0 5417900.0 2141300.0 10611000.0 False True 5245911.730108522 2996332.256731984 7831660.776823408 1.0 0.5711747377552613 1.4929074638969182 22.32276210174482 -6.7801861551271205 1.535025572733563 0.7572476158352343 1.5002669706245946 0.7680851933178989 0.1813607077788178 0.2502867651002348 1.16486726481261 0.09305270519537552 0.21954216592612172 1.6588756978270191e-07 6.7801861551271205 0.7430193547893603 DYIAYAHSTIMPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYIAYAHSTIMPR 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 52325000.0 7366100.0 32542000.0 12416900.0 False True 11174912.234043756 26734625.84819348 9962694.272479387 1.0 2.392379044083041 0.8915232678184788 23.41376016497073 -6.663057913977336 1.9624825822632341 1.8940231298193837 0.8978020281164836 0.2484888723841252 0.592418991239453 0.4772423009258137 3.536606980529571 0.2436433691907512 0.6567848213633607 2.1724114644357946e-07 6.663057913977336 -0.9962211017029001 DYIAYAHSTIMPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYIAYAHSTIMPR 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 39314400.0 16584600.0 7838300.0 14891500.0 False True 22716374.801963013 7491977.988208122 11374434.400069503 1.0 0.32980517593681846 0.5007152109097351 24.43722928459428 -10.611558529439142 9.882870696759218 1.0000847316830355 0.4152601934252947 0.9397856656806712 0.06977372960081228 0.000130282026503786 5.120669365719309e-06 0.06756766135754995 0.022519374395560444 2.445915620201449e-11 10.611558529439142 -0.5848245382577408 DYIAYAHSTIMPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYIAYAHSTIMPR 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 24077800.0 5417900.0 12427400.0 6232500.0 False True 4505223.903666058 12360451.129554246 7535686.934175922 1.0 2.743581982572745 1.6726553652625058 22.103167377179098 -10.138678672685089 4.834146674538008 0.9999301417059233 2.208118673910113 0.6291943682044716 0.43720396081622015 0.00039046933356903226 6.957123861278992e-05 0.42334957456376754 0.14110697158183624 7.266433900358651e-11 10.138678672685089 1.2081885322041894 DYIAYAHSTIMPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYIAYAHSTIMPR 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 38486500.0 7366100.0 21517000.0 9603400.0 False True 9535561.657538617 20319560.03503689 7855679.739205169 1.0 2.1309242984101173 0.8238297880434375 23.184886487063178 -6.677846409919443 1.909340850283828 1.7169225528799164 0.8288634602306405 0.31435941776152576 0.479539249315984 0.443339160060898 3.1228672831536284 0.2016582915012016 0.5333708079780423 2.0996823138657798e-07 6.677846409919443 -0.8880590926492758 DYIHINIGALELSANHNILQIVDVCHDVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYIHINIGALELSANHNILQIVDVCHDVEK 30 0 J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 158518000.0 51936000.0 60624000.0 45958000.0 False True 78790709.03019187 49805173.54252602 36874381.155893035 1.0 0.6321198800665843 0.46800417980453907 26.231522181883854 -13.999999999943578 0.10923912303212623 2.7774764173993933 0.16361532381391275 0.9997469282881917 0.0035385154620585215 12.017200296046829 0.1001694331244233 4.7178882900894425 0.27041493383506626 1.0000000001299175e-14 13.999999999943578 -2.6138610935854807 DYIHINIGALELSANHNILQIVDVCHDVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYIHINIGALELSANHNILQIVDVCHDVEK 30 0 J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 80418300.0 51936000.0 6504300.0 21978000.0 False True 67232175.8116134 6142329.987260783 17978229.513323545 1.0 0.0913599762779027 0.2674051419025779 26.002648503976303 -10.030000548221944 6.8799925402238 1.0000001740010023 0.17938255909024506 0.9666350464910045 0.07187013791070489 1.9182906850207748e-07 2.7053963628106648e-08 0.06958797683955825 0.023195987268148678 9.332531227250028e-11 10.030000548221944 -0.8206176149107572 DYIHINIGALELSANHNILQIVDVCHDVEKDEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYIHINIGALELSANHNILQIVDVCHDVEKDEK 33 1 J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 208325000.0 34853000.0 101770000.0 71702000.0 False True 52874549.09560388 83608348.36736079 57530068.27189695 1.0 1.5812588437621717 1.0880483948501443 25.65607011945954 -10.235980971401816 4.154679142309195 0.9997804458349202 1.3346536192918443 0.3803653492124134 0.20135232269409412 20091461.834142573 49499942.28624751 23552.593443374706 0.06892825757371908 5.807898642522916e-11 10.235980971401816 0.33487317345692413 DYIHINIGALELSANHNILQIVDVCHDVEKDEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYIHINIGALELSANHNILQIVDVCHDVEKDEK 33 1 J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 99565000.0 34853000.0 23643000.0 41069000.0 False True 45117895.55534056 22327246.266132675 33594863.4035255 1.0 0.4948645319404713 0.7446017370716864 25.427196441551988 -10.131014356527125 5.258560748203157 1.000010244118096 0.6197331345058038 0.7555823374122428 0.1019547870610076 1.2245129105810863e-05 2.023570602534331e-06 0.09871995688380651 0.03290576602931125 7.395808262380608e-11 10.131014356527125 -0.3802771096122922 DYIQK(ub)HPELNISEEGITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYIQKHPELNISEEGITK 18 1 P17480;E9PKP7;P17480-2 P17480 UBTF Nucleolar transcription factor 1 1 10477200.0 2792000.0 5044400.0 2640800.0 True False 3660339.037766458 4291795.182917193 2367555.348342319 1.0 1.1725130209621373 0.6468131295802051 21.80354585320261 -6.818307258302318 1.3791985374834905 1.093148083992679 0.6357505614296285 0.8804268565067983 0.07565971589838949 0.19570196980326088 0.7319312105590019 0.04311343452023245 0.09941640737910387 1.5194721404714745e-07 6.818307258302318 -0.45739752256305055 DYIQK(ub)HPELNISEEGITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYIQKHPELNISEEGITK 18 1 P17480;E9PKP7;P17480-2 P17480 UBTF Nucleolar transcription factor 1 1 16323400.0 6888200.0 4610600.0 4824600.0 True False 6669537.8614100525 6451636.62396137 3560892.5251024608 1.0 0.9673288851526792 0.5339039374385721 22.669155368492596 -6.921999491702512 0.8097758363638526 1.0088920163352462 0.4606955739246731 0.9947181076950401 0.01543929534834403 0.09700989691257993 0.09962813216613245 0.013445269127748197 0.04107702813792596 1.196741931971049e-07 6.921999491702512 -0.5481964424105731 DYIQK(ub)HPELNISEEGITK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYIQKHPELNISEEGITK 18 1 P17480;E9PKP7;P17480-2 P17480 UBTF Nucleolar transcription factor 1 1 41113900.0 6121200.0 9565700.0 25427000.0 True False 9286307.919662861 7858626.097844779 20401342.30494998 1.0 0.846259478560354 2.196927183703666 23.14667368856662 -6.878590407875095 1.0875787942382364 0.906368602737574 2.2901173783803395 0.9725328168475644 0.1000600535395371 0.1288884788351779 0.27986469694365745 0.07095665440291178 0.1710007929669651 1.322542363293379e-07 6.878590407875095 1.3837487756427653 up DYIQK(ub)HPELNISEEGITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYIQKHPELNISEEGITK 18 1 P17480;E9PKP7;P17480-2 P17480 UBTF Nucleolar transcription factor 1 1 10330000.0 2792000.0 3654200.0 3883800.0 True False 3824277.8509629807 3492745.3611765443 2966526.429371792 1.0 0.9133084721595336 0.7757089168154451 21.866755914725502 -6.964300855180349 0.36985628423574507 1.0105987607959888 0.6736300853548833 0.9998979946458539 0.0009326888817287546 0.07819903613012139 0.01570147223897357 0.0018140623030026063 0.011687144512250676 1.0856732686999744e-07 6.964300855180349 -0.3369686754411054 DYIQK(ub)HPELNISEEGITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYIQKHPELNISEEGITK 18 1 P17480;E9PKP7;P17480-2 P17480 UBTF Nucleolar transcription factor 1 1 14973800.0 6888200.0 4372500.0 3713100.0 True False 5727843.499000082 4348944.474626703 4489492.042565362 1.0 0.7592638443047379 0.7838014504671957 22.449560643926873 -9.87541013079737 5.255032649466215 1.0000002812338773 0.7715326475124776 0.9914229789870904 0.010017435780912843 3.3010422617525523e-08 7.068399636110808e-09 0.00969935247817095 0.003233113494055668 1.3322627008917903e-10 9.87541013079737 -0.22846763372139967 DYIQK(ub)HPELNISEEGITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYIQKHPELNISEEGITK 18 1 P17480;E9PKP7;P17480-2 P17480 UBTF Nucleolar transcription factor 1 1 66164200.0 6121200.0 11924000.0 48119000.0 True False 7924014.06689094 11260418.91796158 39361835.74263417 1.0 1.4210498395013211 4.967411139147327 22.917800010659068 -6.929150802682802 0.7537313984371252 0.9443366344770893 5.679959423423658 0.9963686633292784 0.1072237752900774 0.09308124587523561 0.07985838819363636 0.09719695926065236 0.32239621307429617 1.1771971373073481e-07 6.929150802682802 4.735622788946569 up DYITK(ub)ASSMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYITKASSMR 10 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 22493400.0 9837500.0 8757200.0 3898700.0 True False 12897057.766485525 7450659.8952982435 3495299.92297115 1.0 0.5777022969269497 0.2710152956013026 23.62053864227517 -8.042073033127151 0.2494208860339426 1.1821479188176374 8.149918117548966e-14 0.9995910363134208 0.006043630219875734 0.09648386812304947 0.04729013262433083 0.07220411539871503 0.09769357104354698 9.076678793835414e-09 8.042073033127151 -1.1821479188175559 down DYITK(ub)ASSMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYITKASSMR 10 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 32956900.0 18617000.0 9755100.0 4584800.0 True False 18026013.525430575 13650362.302174453 3383903.338948257 1.0 0.7572590735559429 0.1877233329584683 24.103577042512857 -7.113982782375253 0.534982282962977 1.0071647984770309 1.3587224570986597e-11 0.9992312110941902 0.009439360846978332 0.07779522585384846 0.035336325008086186 0.010332660126642943 0.044322552928956524 7.691609331027969e-08 7.113982782375253 -1.0071647984634438 down DYITK(ub)ASSMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYITKASSMR 10 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 59812400.0 36727000.0 15278000.0 7807400.0 True False 55717544.10335531 12551521.532441154 6264263.967895023 1.0 0.22527054511157646 0.11242893183294109 25.731628332990706 -13.999999999999998 0.2713239108028279 7.022377407484272 0.07545068047799841 0.9995861816973267 0.008025264519187556 14.948308006193757 0.16490346918459028 49.696154202944484 0.04655737752256883 1.0000000000000041e-14 13.999999999999998 -6.946926727006273 DYITK(ub)ASSMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYITKASSMR 10 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 19970300.0 9837500.0 7831100.0 2301700.0 True False 13474689.598441396 7485096.108015348 1758085.8649994961 1.0 0.555493026635741 0.13047319956096445 23.683748703798063 -7.80824491027662 0.41647635645184505 1.0445724824227207 1.3813449348461922e-19 0.9975902549571722 0.01742726451340112 0.11224635407978142 0.07726783919273511 0.03383136478395031 0.07868952000152453 1.555088428322564e-08 7.80824491027662 -1.0445724824227207 down DYITK(ub)ASSMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYITKASSMR 10 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 37352500.0 18617000.0 16046000.0 2689500.0 True False 15480860.372939875 15959557.013118386 3251862.0151570197 1.0 1.0309218369422968 0.21005693074017942 23.883982317947133 -6.898146687132017 0.9729210305915185 1.0358856528193379 0.12706741336649888 0.9856211583409165 0.045552203775618735 0.11278197864336145 0.18521833884723382 0.03523447125713854 0.09084960841915427 1.2643092427572973e-07 6.898146687132017 -0.908818239452839 down DYITK(ub)ASSMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYITKASSMR 10 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 61661600.0 36727000.0 18914000.0 6020600.0 True False 47543825.49740314 17861419.27325777 4924912.576572736 1.0 0.37568325826522664 0.10358679649877431 25.502754655083155 -9.160359826727213 0.30591745786201563 1.272878224993133 3.3519444820247e-24 0.9985322724114742 0.014376468258849273 0.5919782444616974 0.11351635576611606 0.26924596694414554 0.08996020933914656 6.912580044506538e-10 9.160359826727213 -1.272878224993133 DYIVVGSDSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYIVVGSDSGR 11 0 Q15393;Q15393-2;J3QL37;J3QRB2 Q15393 SF3B3 Splicing factor 3B subunit 3 0 24194400.0 4565300.0 10154000.0 9475100.0 False True 5985152.510428088 8639062.779981995 8494707.543577077 1.0 1.4434156464567829 1.4192967562274355 22.512956578938226 -10.16642174143372 4.8499207089789635 0.9999609116277411 1.4313562013436982 0.9976606951258011 0.009846495709497227 4.16202937867658e-06 7.153584938964105e-07 0.009534690583149966 0.003177942824335199 6.816763997077561e-11 10.16642174143372 0.4313952897159571 DYIVVGSDSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYIVVGSDSGR 11 0 Q15393;Q15393-2;J3QL37;J3QRB2 Q15393 SF3B3 Splicing factor 3B subunit 3 0 18421700.0 4565300.0 5652900.0 8203500.0 False True 6253214.782593591 5403136.186359507 6266002.256385881 1.0 0.8640573487735689 1.0020449439587276 22.576166640461118 -10.963266805598549 8.445611411590717 1.032772446197901 0.933051146366148 0.2388876503835844 0.0563331998395606 0.03704245466157666 0.00016111175119191097 0.058122445171735176 0.018181462068099365 1.0882613226434636e-11 10.963266805598549 -0.09972129983175304 DYIVVGSDSGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYIVVGSDSGR 11 0 Q15393;Q15393-2;J3QL37;J3QRB2 Q15393 SF3B3 Splicing factor 3B subunit 3 0 6950200.0 3689500.0 0.0 3260700.0 False True 3067982.722563342 0.0 3942497.2942266166 1.0 0.0 1.2850454682263026 21.548858927607533 -6.699055865502184 1.8344725120769765 0.3784464201712075 1.2811219293566534 0.4129423633097733 0.4221886697821519 0.3975154762268007 2.6001821931751787 0.18365780339312363 0.47282923726647397 1.9996046338012e-07 6.699055865502184 0.9026755091854459 DYIWNTLNSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYIWNTLNSGR 11 0 O75390;B4DJV2;A0A0C4DGI3;H0YIC4 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 0 17538300.0 3514100.0 6257800.0 7766400.0 False True 4607019.130592803 5324160.632713348 6962807.42856929 1.0 1.1556628009982386 1.5113476265668033 22.13540215805294 -6.957358816748147 0.4711838663444146 0.9907126546208187 1.6909082150939747 0.9996593509144314 0.003949989097141604 0.08065845121915784 0.024722328172934713 0.004928927103312604 0.029354210620444174 1.1031668001439e-07 6.957358816748147 0.700195560473156 DYIWNTLNSGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYIWNTLNSGR 11 0 O75390;B4DJV2;A0A0C4DGI3;H0YIC4 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 0 15636300.0 5929700.0 1687600.0 8019000.0 False True 5741464.919253675 2361467.48071774 5918583.335156618 1.0 0.41130051544836466 1.0308489938358738 22.452987452932707 -9.373262004857368 13.490854148992172 0.9999998331051689 0.7210751518031433 0.2127526591418456 0.25292960716141444 0.0 0.0 0.24489803907500907 0.08163267969166968 4.2338746420737806e-10 9.373262004857368 -0.27892468130202563 DYIWNTLNSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYIWNTLNSGR 11 0 O75390;B4DJV2;A0A0C4DGI3;H0YIC4 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 0 16469600.0 3514100.0 6328700.0 6626800.0 False True 4813357.734981735 6049077.107787749 5061686.323230069 1.0 1.2567271000501903 1.0515915504147078 22.198612219575832 -10.465071981668155 3.215270233354048 0.9970644878107116 1.1541593253214053 0.42955018037652204 0.08374623822334928 20570725.123677514 28738245.02159934 547440.0791415393 0.03064798178788907 3.427109795790429e-11 10.465071981668155 0.15709483751069375 DYIWNTLNSGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYIWNTLNSGR 11 0 O75390;B4DJV2;A0A0C4DGI3;H0YIC4 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 0 10674000.0 5929700.0 2891400.0 1852900.0 False True 4930808.280250394 2875823.454302036 2240332.823158373 1.0 0.583235707180243 0.45435407256284677 22.233392728366983 -13.999999999999998 0.16435239704608104 3.0725091550228636 0.3335503608398839 0.999525602840666 0.005071936934701941 12.041515480061454 0.1282470496647147 7.954152643056417 0.11073462926882235 1.0000000000000041e-14 13.999999999999998 -2.7389587941829796 DYK(ub)SSFADISNLLQIEPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYKSSFADISNLLQIEPR 18 1 Q15785 Q15785 TOMM34 Mitochondrial import receptor subunit TOM34 1 7088600.0 3527800.0 1493100.0 2067700.0 True False 3415811.9200200895 2089302.616413637 1526107.3403296343 1.0 0.6116562226884404 0.44677733319715646 21.703797109410086 -13.999999999999998 0.117123415255408 2.8555624543987874 0.17312375648981643 0.9997071657303055 0.003968577919397781 11.97569578798757 0.10494297444737012 5.193177329485615 0.24282276979513714 1.0000000000000041e-14 13.999999999999998 -2.682438697908971 DYK(ub)VDQEIINIMQDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYKVDQEIINIMQDR 15 1 O96000-2;O96000;H3BV16 O96000-2 NDUFB10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 1 54564200.0 2292200.0 10350000.0 41922000.0 True False 3477434.982266747 8502961.635080902 33636098.32493466 1.0 2.4451820604675385 9.672674973497033 21.729592110220164 -6.939800482504444 0.6614182874465984 0.9185897083286059 11.610305283325028 0.9981376324831738 0.16372470522921692 0.08785781678406819 0.055025320925850295 0.15913358654728574 0.6226049022198007 1.1486812113519126e-07 6.939800482504444 10.691715574996422 DYK(ub)VDQEIINIMQDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYKVDQEIINIMQDR 15 1 O96000-2;O96000;H3BV16 O96000-2 NDUFB10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 1 5702650.0 705200.0 848050.0 4149400.0 True False 965931.497313429 810580.3468736715 3169397.1795754954 1.0 0.839169598597996 3.2811821422022414 19.88156135294867 -6.891158839774614 1.0154791838052941 0.8724101293397146 3.4960677203467974 0.9816305053226285 0.1511479371650132 0.1182088418665284 0.21638469243938044 0.11323336198470439 0.2835024905220285 1.284816662459275e-07 6.891158839774614 2.623657591007083 up DYK(ub)VDQEIINIMQDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYKVDQEIINIMQDR 15 1 O96000-2;O96000;H3BV16 O96000-2 NDUFB10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 1 54871300.0 2292200.0 4984100.0 47595000.0 True False 2967298.086017025 4706730.453623978 38933198.36594018 1.0 1.5862007513851688 13.120757415443835 21.500718432312613 -6.9174484974844965 0.8434409210758816 0.7213502912747437 14.87582218124572 0.9934421875099227 0.45193048971644173 0.09969626084484678 0.11356753627763598 0.38421261988285543 1.1242542337259915 1.2093485897883567e-07 6.9174484974844965 14.154471889970976 up DYLDFLDDEEDQGIYQSK(ub)VR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYLDFLDDEEDQGIYQSKVR 20 1 P25205;P25205-2 P25205 MCM3 DNA replication licensing factor MCM3 1 24097100.0 7996200.0 5801900.0 10299000.0 True False 7742365.00789858 8118628.926508794 7601382.936622775 1.0 1.0485980599243716 0.9817908260419164 22.884342893316063 -6.711605863729896 1.7891679644603622 1.0298274475411722 0.9819381410366981 0.4728442357543895 0.02047387893383886 0.3718698744520834 2.321395182689439 0.009102413448380156 0.02308219243446039 1.942648093730681e-07 6.711605863729896 -0.047889306504474094 DYLDFLDDEEDQGIYQSK(ub)VR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYLDFLDDEEDQGIYQSKVR 20 1 P25205;P25205-2 P25205 MCM3 DNA replication licensing factor MCM3 1 48633200.0 9153200.0 11572000.0 27908000.0 True False 13886073.588554248 9506886.187551329 22391971.567489088 1.0 0.6846345820453873 1.6125488191237818 23.727135386273392 -6.8149942711199785 1.3933810246330998 0.8291140772013537 1.6307139604664689 0.8724864097150133 0.13756591231068588 0.20006442254234785 0.764539911450064 0.07760855230466875 0.1791583185412086 1.531107658747821e-07 6.8149942711199785 0.8015998832651152 DYLDFLDDEEDQGIYQSK(ub)VR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYLDFLDDEEDQGIYQSKVR 20 1 P25205;P25205-2 P25205 MCM3 DNA replication licensing factor MCM3 1 29747400.0 7996200.0 8023200.0 13728000.0 True False 6649194.591722714 7979977.42911948 16598461.328899644 1.0 1.2001419599079561 2.4963115607358417 22.66474816875034 -6.934241235202876 0.7111222482697541 0.9830477168026376 2.793624469683248 0.9973080548963694 0.03441184200968463 0.0904946475269969 0.06732613043266693 0.03218316374219636 0.11466928156573243 1.1634795781891143e-07 6.934241235202876 1.8105767528806105 up DYLETLMASQK(ub)AADWIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYLETLMASQKAADWIR 17 1 Q96G46-3;Q96G46;K7EM42;K7EMI3 Q96G46-3 DUS3L tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like 1 6720400.0 1491300.0 1051800.0 4177300.0 True False 1443959.4977963495 1471789.2250645394 3083139.8136862125 1.0 1.019273204899903 2.1351982644883347 20.461598845380394 -6.910647023913673 0.8913076792824863 0.9661514418237295 2.2814312426847723 0.9911636202579803 0.049882471604756125 0.10399209776764917 0.1364546363908399 0.040970484326157186 0.11361193728249114 1.2284372470856134e-07 6.910647023913673 1.3152798008610427 up DYLETLMASQK(ub)AADWIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYLETLMASQKAADWIR 17 1 Q96G46-3;Q96G46;K7EM42;K7EMI3 Q96G46-3 DUS3L tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like 1 7383800.0 1491300.0 1308500.0 4584000.0 True False 1240082.025791763 1301450.8507830861 5542493.205978725 1.0 1.0494877142922385 4.469456931641255 20.24200412081467 -6.910050393351637 0.8953923795958839 0.8942799559488447 4.911906113004359 0.9909405681837763 0.15457202152834082 0.10438464003017721 0.13858681907103626 0.1265817753092722 0.3495447299151909 1.2301260248817611e-07 6.910050393351637 4.017626157055514 up DYLETLMASQK(ub)AADWIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYLETLMASQKAADWIR 17 1 Q96G46-3;Q96G46;K7EM42;K7EMI3 Q96G46-3 DUS3L tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like 1 24986700.0 3417000.0 3375700.0 18194000.0 True False 4423373.859139775 3187839.327521215 14882878.686204776 1.0 0.7206805097277404 3.364598869583022 22.076715751857602 -6.8807849049137815 1.0753766583243354 0.8250049241368655 3.554841715787087 0.9743145583356236 0.19007856253655403 0.1269386834781186 0.2680847347704424 0.13605769458432546 0.3296980535076268 1.3158763911648954e-07 6.8807849049137815 2.7298367916502215 up DYLHLPPEIVPATLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYLHLPPEIVPATLR 15 0 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 0 14943000.0 6267900.0 2523900.0 6151200.0 False True 6068928.945374999 3531706.4319646265 4540016.187955526 1.0 0.5819324074729965 0.7480753570883995 22.533010499060786 -10.110736262823272 5.16166202753683 1.0000086091625804 0.6650038822801982 0.8442534620425255 0.0678275751548541 6.719972118903971e-06 1.1577148349024672e-06 0.06567545468115457 0.021891255748781365 7.749322536996714e-11 10.110736262823272 -0.33500472688238214 DYLHYHIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYLHYHIK 8 0 O15144;H7C3F9 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 7608400.0 0.0 0.0 7608400.0 False True 0.0 0.0 6821155.752926272 0.0 DYNNSYYGLMLFGHPLLVSVPR ddPTM_RPMI8226_Bortezomib_8h_R1 2 DYNNSYYGLMLFGHPLLVSVPR 22 0 P51784;G5E9A6 P51784 USP11 Ubiquitin carboxyl-terminal hydrolase 11;Ubiquitin carboxyl-terminal hydrolase 0 593708700.0 201456000.0 216084500.0 176168200.0 False True 305623480.4063916 177522532.69909543 141348478.05273497 1.0 0.5808537107915968 0.46249220728977375 28.18718014594295 -13.999999999765784 0.17736772439884171 3.1576145939606204 0.36587153538330747 0.9995015496015902 0.005148482960670752 12.171803343026802 0.13348064206843357 9.045481464607269 0.09039030528181662 1.0000000005393027e-14 13.999999999765784 -2.791743058577313 DYNNSYYGLMLFGHPLLVSVPR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 DYNNSYYGLMLFGHPLLVSVPR 22 0 P51784;G5E9A6 P51784 USP11 Ubiquitin carboxyl-terminal hydrolase 11;Ubiquitin carboxyl-terminal hydrolase 0 430963800.0 201456000.0 152103900.0 77403900.0 False True 260788763.29144344 143639184.25492617 63317184.431082964 1.0 0.550787474283939 0.24279107593421537 27.9583064680354 -8.207035222135065 0.2576205496513619 1.1899048314341332 1.3185225876870759e-18 0.999435717689838 0.007385692233644566 0.08938178776580469 0.05624141917967722 0.0896495527886108 0.10197676775244634 6.208186825743683e-09 8.207035222135065 -1.1899048314341332 down DYNQK(ub)LK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYNQKLK 7 1 A0A087WT20;Q9NV06 A0A087WT20 DCAF13 DDB1- and CUL4-associated factor 13 1 3577240.0 647840.0 1301400.0 1628000.0 True False 849324.5136914835 1107236.1928174694 1459550.1768787107 1.0 1.303666825775468 1.7184835164299652 19.69595636489469 -6.966765328575814 0.3263375220659555 0.94725455453767 2.0884014781250713 0.9999450462415038 0.0021830504349467242 0.07736690615700666 0.012774474298471858 0.0061343635005077874 0.03629005975478327 1.0795298896304741e-07 6.966765328575814 1.1411469235874012 DYNQK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYNQKLK 7 1 A0A087WT20;Q9NV06 A0A087WT20 DCAF13 DDB1- and CUL4-associated factor 13 1 4378680.0 806680.0 1641400.0 1930600.0 True False 781072.3849543077 2296819.5797879235 1424917.9432414712 1.0 2.94059759893097 1.8243097191623643 19.57509672904674 -10.543028888976318 6.092321237578133 0.997726815720059 2.382453659046591 0.6715898143347984 0.4557226185810638 0.014079611804024663 0.0010560776639796875 0.4415256465968639 0.1470838426878745 2.8639874530544406e-11 10.543028888976318 1.384726843326532 DYNQK(ub)LK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYNQKLK 7 1 A0A087WT20;Q9NV06 A0A087WT20 DCAF13 DDB1- and CUL4-associated factor 13 1 3051240.0 647840.0 623100.0 1780300.0 True False 887363.9552177138 595569.3816838451 1359829.8064294234 1.0 0.6711669751536423 1.53243750597892 19.759166426417583 -6.803235991716285 1.4427609944342366 0.8193066266295433 1.5452850011613812 0.8414292016695852 0.14131343286574544 0.2161720093732879 0.8880077090825337 0.07704396412961832 0.17882667697203986 1.5731278086667974e-07 6.803235991716285 0.7259783745318379 DYNQK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYNQKLK 7 1 A0A087WT20;Q9NV06 A0A087WT20 DCAF13 DDB1- and CUL4-associated factor 13 1 3466880.0 806680.0 1453800.0 1206400.0 True False 670790.1619833028 1445968.0908432936 1458652.6622366358 1.0 2.155619108318536 2.174529003114605 19.355502004481018 -10.903315647046867 0.7095133111993094 6.756799663987072e-14 2.1711485417350223 0.9999699659774082 0.00301020536817934 2.763939832459939 0.363481662430949 4.598382800118002 0.002922660920185855 1.2493506668636499e-11 10.903315647046867 2.1711485417349548 DYNVTANSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYNVTANSK 9 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 P00338 LDHA L-lactate dehydrogenase A chain 0 31814900.0 2648900.0 16135000.0 13031000.0 False True 3472733.5519840918 13727720.89373741 11682677.122178437 1.0 3.953001486651428 3.364115601527714 21.727640292460638 -10.57741225144241 8.800157485634978 0.9994920693389839 3.6585585440895607 0.9645074909455152 0.24041165588005514 0.002396030060622711 0.00011505899461732911 0.23279733743612877 0.07759252828813341 2.6459872585295277e-11 10.57741225144241 2.659066474750577 DYNVTANSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYNVTANSK 9 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 P00338 LDHA L-lactate dehydrogenase A chain 0 24558900.0 6902800.0 2751100.0 14905000.0 False True 6683674.392401683 3849628.576796969 11000933.359584669 1.0 0.5759748830932591 1.6459409471070359 22.672210020869652 -6.799162162946856 1.4591563741846405 0.7657979272772174 1.660436994732766 0.8297554939516273 0.18151915772434493 0.22195220721404316 0.9330209417584148 0.09786556736244716 0.22773407678219912 1.5879537055246923e-07 6.799162162946856 0.8946390674555486 DYNVTANSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYNVTANSK 9 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 P00338 LDHA L-lactate dehydrogenase A chain 0 27169900.0 2648900.0 12133000.0 12388000.0 False True 3628269.913830893 11596923.941534419 9462209.538868556 1.0 3.196268253728085 2.6079122456680524 21.79085035398353 -10.133320554224214 5.160482447606729 0.9999359199442941 2.902090249700243 0.9330451458825293 0.2401953344822581 0.00017709941916061183 2.974437801234176e-05 0.23257582976230912 0.07752271085611519 7.356639010412704e-11 10.133320554224214 1.902154329755949 DYQDNK(ub)ADVILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYQDNKADVILK 12 1 O14602;P47813;X6RAC9 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 1 108377900.0 41393000.0 62932000.0 4052900.0 True False 54266623.85038226 53542790.90701464 3633544.786161991 1.0 0.9866615445736353 0.0669572663333541 25.69356181969814 -6.964921245383699 0.962906325836564 1.0235490548539357 1.177905293400577e-19 0.9904852155446682 0.04260034375941526 0.09135781971482758 0.15109046185243602 0.03463237357305572 0.07962528033421887 1.0841234902895658e-07 6.964921245383699 -1.0235490548539357 down DYQDNK(ub)ADVILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYQDNKADVILK 12 1 O14602;P47813;X6RAC9 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 1 92655000.0 44187000.0 43218000.0 5250000.0 True False 42784307.87174093 60475172.77889265 3874867.50337601 1.0 1.4134895663191633 0.09056749299280736 25.350578416286755 -6.822709202061778 1.3600259066263887 1.2222828484246722 0.05995423577993979 0.890514376288764 0.18284311441298 0.18998753537353508 0.6897449174027468 0.10562406200081527 0.24329883774760344 1.5041487874457266e-07 6.822709202061778 -1.1623286126447323 down DYQDNK(ub)ADVILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYQDNKADVILK 12 1 O14602;P47813;X6RAC9 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 1 163972700.0 118201000.0 25653700.0 20118000.0 True False 179319558.6506032 21075596.80172705 16141668.481967367 1.0 0.11753094286157588 0.09001621799336873 27.417957612778313 -12.96238532833166 0.5075291812820281 9.999999977605636 0.0915812358994452 0.9999332153105103 0.0034538444990672244 16.777203486095196 0.25310138432332496 166.24352712020462 0.005527196046634695 1.0904723840934846e-13 12.96238532833166 -9.90841874170619 DYQDNK(ub)ADVILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYQDNKADVILK 12 1 O14602;P47813;X6RAC9 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 1 83214900.0 41393000.0 40374000.0 1447900.0 True False 56697110.70376466 38590143.181036025 1105935.8404365354 1.0 0.6806368561294898 0.019506035258391074 25.75677188122103 -7.455088509891708 0.6966577183914714 0.9941238522449195 1.2932655648646707e-17 0.9896333125884543 0.04157289405809101 0.11521338646089073 0.1252818762634896 0.03696795474467543 0.07300363799303124 3.506803974582129e-08 7.455088509891708 -0.9941238522449195 down DYQDNK(ub)ADVILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYQDNKADVILK 12 1 O14602;P47813;X6RAC9 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 1 117872000.0 44187000.0 71555000.0 2130000.0 True False 36743448.31600658 71169519.01244459 2575373.1519927285 1.0 1.9369308618059387 0.07009067657024495 25.13098369172103 -6.770242014634326 1.5735286194246423 1.537217199020359 0.059482820965258955 0.7315298057031532 0.3948940390995636 0.266013214302268 1.2998951685647282 0.19781134214261487 0.4707683494290215 1.6972975540464875e-07 6.770242014634326 -1.4777343780551 DYQDNK(ub)ADVILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYQDNKADVILK 12 1 O14602;P47813;X6RAC9 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 1 160369800.0 118201000.0 32320000.0 9848800.0 True False 153013524.59004414 30521363.588436622 8056419.457221795 1.0 0.19946840431399684 0.05265168212291469 27.189083934870762 -13.082120656157434 0.2565745777514675 4.421099985675324 2.9495557387991116e-22 0.9994571792436959 0.009699554000244207 9.294030209940159 0.16149066784980481 16.36114501583843 0.0653291880083971 8.277121758841511e-14 13.082120656157434 -4.421099985675324 DYQGPLK(ub)EHEVTIFVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYQGPLKEHEVTIFVR 16 1 P53396;P53396-2;P53396-3;K7EIE7 P53396 ACLY ATP-citrate synthase 1 37649700.0 3378900.0 5749800.0 28521000.0 True False 5126038.330678442 4723703.266607556 22883811.848801635 1.0 0.9215114991117056 4.464229561422908 22.289412835950728 -6.901834318266253 0.9495964106557594 0.8600281580109325 4.850269852496535 0.9874570786908082 0.18500083601749814 0.11006771509286466 0.1699016985115944 0.1455965534021678 0.38242646784478773 1.2536193348532034e-07 6.901834318266253 3.990241694485602 up DYQQQK(ub)MEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYQQQKMEK 9 1 Q99567;J3KMX1 Q99567 NUP88 Nuclear pore complex protein Nup88 1 1678430.0 592600.0 642810.0 443020.0 True False 776904.3387465625 546905.2536537554 397180.54014791513 1.0 0.7039544334842026 0.5112348076067075 19.567377443066878 -8.54747272034131 0.11530080117905302 1.5212432345830678 3.8140130044702076e-14 0.9999618351940107 0.0012418308695878117 0.17314169779770788 0.02893221548036172 0.19147132620593246 0.16658548926567954 2.8348316942653474e-09 8.54747272034131 -1.5212432345830296 DYQQQK(ub)MEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYQQQKMEK 9 1 Q99567;J3KMX1 Q99567 NUP88 Nuclear pore complex protein Nup88 1 1196690.0 592600.0 0.0 604090.0 True False 811700.2344128444 0.0 461416.3836240799 1.0 0.0 0.5684566346809699 19.63058750458977 -10.214672806009677 6.1112824522553115 1.0000113610323245 0.2842283173404829 0.6788636473751295 0.2320714493113552 3.5923758445747e-05 4.616138140015989e-06 0.22470577639871805 0.07490073819275685 6.099962904949533e-11 10.214672806009677 -0.7157830436918415 DYQQQK(ub)MEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYQQQKMEK 9 1 Q99567;J3KMX1 Q99567 NUP88 Nuclear pore complex protein Nup88 1 1513410.0 391210.0 630600.0 491600.0 True False 325308.4485415377 627202.8326357001 594391.2870984158 1.0 1.9280250342333622 1.8271621587550613 18.31144876533938 -10.075034020158604 4.701770305821014 0.9999611260306295 1.8775935965132298 0.990190299687523 0.04117709654878859 28591966.641206335 0.7014923173206892 12162.882661659218 0.014096015385667897 8.413292341187278e-11 10.075034020158604 0.8776324704826003 DYSAPVNFISAGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYSAPVNFISAGLK 14 0 Q9UBB9;F6UKU9;F6SQZ1;F6XM96 Q9UBB9 TFIP11 Tuftelin-interacting protein 11 0 4893100.0 1123200.0 1872700.0 1897200.0 False True 1472526.0770842715 1593300.4597274265 1700895.9432274501 1.0 1.0820185017587591 1.1550871456180734 20.489861752410157 -6.972490869319135 0.1894613630257385 0.9501282157097062 1.2889724532173468 0.9999958468589315 0.00012897178828599008 0.07550244354178022 0.006040366508041627 0.002591532608778084 0.007977217018485853 1.065391262398747e-07 6.972490869319135 0.3388442375076406 DYSAPVNFISAGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYSAPVNFISAGLK 14 0 Q9UBB9;F6UKU9;F6SQZ1;F6XM96 Q9UBB9 TFIP11 Tuftelin-interacting protein 11 0 3922400.0 1123200.0 1300400.0 1498800.0 False True 1538477.393338689 1242944.0281522598 1144814.308754939 1.0 0.8079052922935157 0.7441216320186208 20.553071813933048 -13.999999999999998 0.15405940255160508 1.9351447111930038 0.6771196203732118 0.999553258073563 0.002298598964440445 11.9753414648586 0.12380943142908456 3.3490369574003225 0.06064366356078647 1.0000000000000041e-14 13.999999999999998 -1.258025090819792 DYSLSGAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYSLSGAYR 9 0 Q96PZ0;Q96PZ0-2 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 9541200.0 2904000.0 2308300.0 4328900.0 False True 3807172.1223760084 1963910.637682926 3880986.953740942 1.0 0.5158449827210002 1.0193883620157596 21.860288364988712 -10.960252384648744 12.346637672828315 1.0750681237436248 0.76761667236838 0.22116656624525177 0.20557072377148206 0.10151348198970789 0.00032680266902529524 0.04756672594730402 0.0663476658028963 1.0958411770669298e-11 10.960252384648744 -0.30745145137524477 DYSLSGAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYSLSGAYR 9 0 Q96PZ0;Q96PZ0-2 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 5332800.0 2904000.0 0.0 2428800.0 False True 3977687.2776491824 0.0 1855167.4627061624 1.0 0.0 0.4663934928043334 21.923498426511603 -10.363670261172174 7.506500828381126 1.0000128254979415 0.2331967464021693 0.7828041768889689 0.19040434612083912 4.086906137117733e-05 3.464750357383886e-06 0.18436128858676834 0.06145273846429355 4.328423425963195e-11 10.363670261172174 -0.7668160790957721 DYSVTANSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYSVTANSK 9 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 9667300.0 1708500.0 3958100.0 4000700.0 False True 2239860.0451375367 3367566.9085529614 3586745.941424233 1.0 1.5034720208807415 1.6013259173092629 21.09497715942223 -11.713480879314579 0.2767360034795561 8.542054017225985e-10 1.6353631524206955 0.9993709237531226 0.006607686072199667 4.432169635327392 0.15316771123098047 2.634823270853546 0.039236972285862946 1.934279017257011e-12 11.713480879314579 1.6353631515664901 DYSVTANSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYSVTANSK 9 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 8330300.0 1708500.0 2564600.0 4057200.0 False True 2340178.6204764545 2451287.4920019093 3098972.9206568887 1.0 1.0474787995041308 1.324246317584914 21.15818722094512 -6.936448445968034 0.691810950785709 0.9966216233675984 1.39168043408383 0.9976608006768188 0.006915276018305207 0.08942472815329894 0.0622709452389488 0.006562514695557225 0.02421688462613612 1.1575814375877014e-07 6.936448445968034 0.3950588107162316 DYTGCSTSESLSPVK(ub)QAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYTGCSTSESLSPVKQAPR 19 1 O95297-4;O95297-2;O95297 O95297-4 MPZL1 Myelin protein zero-like protein 1 1 176736900.0 60957400.0 65308200.0 50471300.0 True False 79915741.7123013 55564471.12936973 45249014.03089583 1.0 0.6952881865177857 0.5662090229205834 26.251976375792598 -13.999999999999998 0.11747851612306334 2.45544267089398 0.3530133659755308 0.9997053985004808 0.0031215780401499496 11.974174625699106 0.10515140049805026 4.083077451160367 0.1891757219499982 1.0000000000000041e-14 13.999999999999998 -2.1024293049184495 DYTGCSTSESLSPVK(ub)QAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYTGCSTSESLSPVKQAPR 19 1 O95297-4;O95297-2;O95297 O95297-4 MPZL1 Myelin protein zero-like protein 1 1 62258710.0 28136710.0 21226000.0 12896000.0 True False 27243525.54230635 29701652.492127713 9518150.72829276 1.0 1.0902279312566998 0.34937294417024206 24.69941007656606 -6.87644541015511 1.0994749560121346 1.0536737682374302 0.30032923827940916 0.9707013521339711 0.05649201612070382 0.13082323078990155 0.2917344125752957 0.03969939459431784 0.09519069249567655 1.3290906103439684e-07 6.87644541015511 -0.753344529958021 down DYTGCSTSESLSPVK(ub)QAPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYTGCSTSESLSPVKQAPR 19 1 O95297-4;O95297-2;O95297 O95297-4 MPZL1 Myelin protein zero-like protein 1 1 165123600.0 101329600.0 39651000.0 24143000.0 True False 153724411.38604695 32574969.25532302 19371125.467747208 1.0 0.21190498608264466 0.12601203213652676 27.195771041818702 -13.999999999999998 0.31300906231200837 8.753594110819991 0.10759726828119381 0.9996785902101887 0.0070514538253895675 17.486752451541484 0.17812777607216404 88.4530789585724 0.029402669657499075 1.0000000000000041e-14 13.999999999999998 -8.645996842538798 DYTGCSTSESLSPVK(ub)QAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYTGCSTSESLSPVKQAPR 19 1 O95297-4;O95297-2;O95297 O95297-4 MPZL1 Myelin protein zero-like protein 1 1 142252000.0 60957400.0 33608600.0 47686000.0 True False 83494998.09179474 32123660.923222117 36423548.92399788 1.0 0.3847375490434197 0.43623629865771935 26.31518643731549 -10.325826577246476 8.874664269902262 1.0000006129580024 0.4104869256963656 0.994308992643967 0.0210242764910644 2.5498967995206295e-07 1.9346045288569905e-08 0.020356689106107346 0.006785556059662737 4.722515834245603e-11 10.325826577246476 -0.5895136872616368 DYTGCSTSESLSPVK(ub)QAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYTGCSTSESLSPVKQAPR 19 1 O95297-4;O95297-2;O95297 O95297-4 MPZL1 Myelin protein zero-like protein 1 1 67110310.0 28136710.0 14832000.0 24141600.0 True False 23396921.03259928 14752097.072078506 29189496.94185338 1.0 0.6305144617757262 1.2475785553656062 24.479815352000337 -6.744533243218065 1.6699706750419552 0.7813185463794713 1.2483184559786842 0.6251421028804409 0.15523685537194962 0.3096891497755154 1.6974105502163195 0.07348719312160767 0.1794504676022581 1.8008052859162278e-07 6.744533243218065 0.4669999095992129 DYTGCSTSESLSPVK(ub)QAPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYTGCSTSESLSPVKQAPR 19 1 O95297-4;O95297-2;O95297 O95297-4 MPZL1 Myelin protein zero-like protein 1 1 157227200.0 101329600.0 36916600.0 18981000.0 True False 131173164.70503052 34862158.757700495 15526652.761506665 1.0 0.2657720337547328 0.11836760054102145 26.96689736391115 -13.99999999999993 0.22572123067431082 5.545060226258486 0.04371683715042661 0.9995042586749501 0.008585183757484752 13.161639149302703 0.15046367939309607 26.746596232530436 0.07860601720921077 1.0000000000001595e-14 13.99999999999993 -5.50134338910806 DYTGEDVTPQNFLAVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYTGEDVTPQNFLAVLR 17 0 Q99538;Q99538-2;Q99538-3;G3V4E4;G3V2T4;H0YJN9 Q99538 LGMN Legumain 0 6547800.0 1549400.0 2944900.0 2053500.0 False True 2031278.404410942 2505532.3991302927 1841023.5185629171 1.0 1.2334756248525576 0.906337365949008 20.953956556440648 -6.715078162887665 1.776905406398364 1.1427853668868364 0.9069790533198818 0.4892268381766435 0.09831140999984544 0.3649815756936609 2.2493230677322553 0.043976467971889574 0.11104661675802394 1.92717803483391e-07 6.715078162887665 -0.23580631356695458 DYTGEDVTPQNFLAVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYTGEDVTPQNFLAVLR 17 0 Q99538;Q99538-2;Q99538-3;G3V4E4;G3V2T4;H0YJN9 Q99538 LGMN Legumain 0 25443800.0 10387000.0 3480800.0 11576000.0 False True 10057270.370556334 4870701.592132203 8543898.327443946 1.0 0.4842965747835188 0.8495245740292579 23.26173546267306 -10.0454918519085 5.564384325239645 1.0000016267119907 0.6669105744062318 0.525842063200191 0.1491037063221744 3.0089779397917615e-06 5.159408168224236e-07 0.14436974733831656 0.04812301428688331 9.00550658430049e-11 10.0454918519085 -0.33309105230575886 DYTGEDVTPQNFLAVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYTGEDVTPQNFLAVLR 17 0 Q99538;Q99538-2;Q99538-3;G3V4E4;G3V2T4;H0YJN9 Q99538 LGMN Legumain 0 10923400.0 1549400.0 2920700.0 6453300.0 False True 2122255.0509606167 2791653.8165366855 4929163.44988541 1.0 1.3154186228809173 2.3226065348056424 21.01716661796354 -6.9500400657252746 0.5584057545236065 0.9867157762322831 2.699312778198736 0.9992044086388691 0.01590925803367086 0.08346970587676183 0.03589613321068499 0.017086837239824786 0.083695867371768 1.1219149475537826e-07 6.9500400657252746 1.712597001966453 up DYTGEDVTPQNFLAVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYTGEDVTPQNFLAVLR 17 0 Q99538;Q99538-2;Q99538-3;G3V4E4;G3V2T4;H0YJN9 Q99538 LGMN Legumain 0 17570500.0 10387000.0 4890900.0 2292600.0 False True 8637250.722120987 4864551.750932361 2771972.0602152743 1.0 0.5632060371332845 0.3209322213046261 23.042140738107335 -9.303352225446453 0.16960944641548306 1.5149210451083535 1.793855027649504e-12 0.9997158723258234 0.004736455714821239 0.7355022860656156 0.062321488132856824 0.3561376177842229 0.16434565947282914 4.973335693911487e-10 9.303352225446453 -1.5149210451065596 DYTQYYDHISK(ub)QK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYTQYYDHISKQK 13 1 O75794;X6RF82;H7BZW7 O75794 CDC123 Cell division cycle protein 123 homolog 1 32249900.0 12643000.0 14859000.0 4747900.0 True False 16575095.434986155 12642095.119928367 4256632.853072741 1.0 0.7627162793430352 0.2568089498952738 23.98251384122722 -6.990037269716349 0.46121706634977777 1.0146607006354693 7.807202342986328e-11 0.9997205004988715 0.005181688088044153 0.07601242227231514 0.023021725440500795 0.006756564718242318 0.039541502890164316 1.0232051804278102e-07 6.990037269716349 -1.0146607005573973 down DYTQYYDHISK(ub)QK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYTQYYDHISKQK 13 1 O75794;X6RF82;H7BZW7 O75794 CDC123 Cell division cycle protein 123 homolog 1 63585000.0 20802000.0 19014000.0 23769000.0 True False 31558154.82990705 15620803.142939923 19071046.731677193 1.0 0.49498467914658917 0.6043143787863013 24.911509519259873 -9.993905848887636 6.014900426041208 1.0000003999396558 0.5496495289664536 0.9576696310706208 0.0446336629750269 2.3938261832412244e-07 3.998814086815788e-08 0.043216396660652176 0.014405452781848788 1.0141312163747832e-10 9.993905848887636 -0.45035087097320226 DYTQYYDHISK(ub)QK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYTQYYDHISKQK 13 1 O75794;X6RF82;H7BZW7 O75794 CDC123 Cell division cycle protein 123 homolog 1 39761000.0 12643000.0 15555000.0 11563000.0 True False 17317458.764228143 14867728.66649369 8832057.54746021 1.0 0.8585398625117708 0.510008868374162 24.04572390275011 -6.9557732889192385 0.49139346514809845 1.0075318923439598 0.3462025450261944 0.9995799107339206 0.004220265104603728 0.08124696997056262 0.0269841156992076 0.005033244674809955 0.028745891944071764 1.1072016162534836e-07 6.9557732889192385 -0.6613293473177654 DYTQYYDHISK(ub)QK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYTQYYDHISKQK 13 1 O75794;X6RF82;H7BZW7 O75794 CDC123 Cell division cycle protein 123 homolog 1 41016100.0 10975000.0 21295000.0 8746100.0 True False 9126198.774937706 21180279.608273458 10574869.072602652 1.0 2.320821640050025 1.1587375350231548 23.12158264634835 -6.615290352320298 2.1337713922886654 1.8792917922685326 1.1630326294812292 0.06716486463704952 0.5686864596449859 0.598298124013483 5.169324912043436 0.2194794947195219 0.6310152766611032 2.424988300588626e-07 6.615290352320298 -0.7162591627873034 DYTQYYDHISK(ub)QK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYTQYYDHISKQK 13 1 O75794;X6RF82;H7BZW7 O75794 CDC123 Cell division cycle protein 123 homolog 1 66581000.0 20802000.0 21717000.0 24062000.0 True False 26928599.068722717 20508429.859222725 19682962.89696925 1.0 0.7615854730089933 0.7309315589250539 24.682635841352322 -13.999999999999998 0.28919022715441334 3.0450673712103424 0.7225099018754729 0.9996256483654945 0.0023269534738114546 15.9175922195051 0.17051608147435784 19.357113893975846 0.011619545918346998 1.0000000000000041e-14 13.999999999999998 -2.3225574693348694 DYTSGAMLTGELKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYTSGAMLTGELKK 14 1 P23381;P23381-2 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 4305100.0 1804600.0 1142900.0 1357600.0 False True 2471809.387481302 1092402.8989351105 1036962.8406496587 1.0 0.4419446355644096 0.41951569805562233 21.237136064047743 DYVAK(ub)GEDVNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYVAKGEDVNR 11 1 P58546 P58546 MTPN Myotrophin 1 6831800.0 2517000.0 2893100.0 1421700.0 True False 3299811.374662674 2461460.7572154743 1274596.1219093748 1.0 0.7459398364753801 0.38626332756358583 21.65395212815394 -6.966200523852926 0.3368137334199281 1.0404804677428319 0.07982712493412385 0.9999357948608653 0.0020175420448954066 0.07755591156512813 0.013436386092797995 0.005128356692496466 0.031205401228669393 1.0809347433728239e-07 6.966200523852926 -0.9606533428087081 down DYVAK(ub)GEDVNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYVAKGEDVNR 11 1 P58546 P58546 MTPN Myotrophin 1 7946930.0 2943400.0 2444000.0 2559530.0 True False 2849963.3781357002 3419901.9452916267 1889112.3087459037 1.0 1.1999810143275425 0.6628549416595184 21.442511950172968 -6.805855572110678 1.4316514550568986 1.1095324280704442 0.6543018533112529 0.848803923959044 0.08618675021262259 0.21249602724483183 0.859106219282254 0.04734479600700077 0.10974974313879382 1.5636675655682268e-07 6.805855572110678 -0.45523057475919126 DYVAK(ub)GEDVNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYVAKGEDVNR 11 1 P58546 P58546 MTPN Myotrophin 1 16750500.0 5839500.0 4666800.0 6244200.0 True False 8858948.424634285 3833973.078125171 5010031.133069922 1.0 0.43277970413101763 0.5655333898477625 23.078704027404324 -10.030952974554596 7.396498550824383 1.0000000340523492 0.49915654698961925 0.9499448427089604 0.05419646524663823 3.047974595027237e-08 3.911580975015435e-09 0.05247550574059639 0.017491833943628212 9.312087013706133e-11 10.030952974554596 -0.5008434870627299 DYVAK(ub)GEDVNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYVAKGEDVNR 11 1 P58546 P58546 MTPN Myotrophin 1 6210400.0 2517000.0 1255100.0 2438300.0 True False 3447602.9193674186 1199645.5319393266 1862423.758364807 1.0 0.3479651108311055 0.5402083134059222 21.71716218967683 -10.36669876296148 5.271469127814293 1.000255022873769 0.4440867121185307 0.9176912976876019 0.07848295880454292 0.0002353329768113509 2.8272189453796072e-05 0.07602491974409492 0.025330266034245527 4.2983446685449485e-11 10.36669876296148 -0.5561683107552383 DYVAK(ub)GEDVNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYVAKGEDVNR 11 1 P58546 P58546 MTPN Myotrophin 1 8291800.0 2943400.0 3552700.0 1795700.0 True False 2447567.5147290765 3533560.89994426 2171172.5676212893 1.0 1.4437031373720421 0.8870736167870811 21.222917225607244 -6.694344885151527 1.8507329466535913 1.2770281584581127 0.8888767734508085 0.39094502475372717 0.18749236072652062 0.40739648218437535 2.708658207805981 0.08093988931067529 0.20964499941909417 2.02141328142806e-07 6.694344885151527 -0.3881513850073042 DYVAK(ub)GEDVNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYVAKGEDVNR 11 1 P58546 P58546 MTPN Myotrophin 1 18426700.0 5839500.0 6268800.0 6318400.0 True False 7559347.863753796 5919935.76928192 5168516.03225878 1.0 0.7831278406524103 0.6837251209249439 22.849830349496774 -13.999999998385158 0.10482712388255218 2.057517596537963 0.48700322854218436 0.9997693522742265 0.002005507155544741 12.04557545337011 0.09736268671525522 2.724415923724476 0.1750316268947526 1.0000000037183102e-14 13.999999998385158 -1.5705143679957785 DYVAPTANLDQKDK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYVAPTANLDQKDK 14 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 11838900.0 2195500.0 5838700.0 3804700.0 True False 2878321.7612522445 4967588.719074343 3411026.1412594817 1.0 1.7258628920323145 1.1850746456419377 21.4567964461195 -10.36062767656597 5.734855672293624 0.9999018815661803 1.4554687688371275 0.48607380024560676 0.22077587709182703 0.00027702503751211963 3.088555498472844e-05 0.21381101195602556 0.07125510793508101 4.358854008881019e-11 10.36062767656597 0.4555668872709472 DYVAPTANLDQKDK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYVAPTANLDQKDK 14 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 9783800.0 4902800.0 1864300.0 3016700.0 True False 4747163.297657032 2608724.7121960646 2226535.7709398894 1.0 0.5495333841756832 0.4690244744769574 22.17863424720779 -13.999999999999998 0.24219629380872534 4.013705818482785 0.4341620625894182 0.9995286587786003 0.005072661128394939 13.701958894455418 0.1557510878297174 19.997326784639757 0.038838368425272426 1.0000000000000041e-14 13.999999999999998 -3.579543755893367 DYVAPTANLDQKDK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYVAPTANLDQKDK 14 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 47192600.0 6461800.0 11518800.0 29212000.0 True False 9803023.020858243 9463180.143204829 23438235.395925533 1.0 0.9653328491700653 2.390919142600722 23.224795280253144 -6.901326475901516 0.9528345034234782 0.9428672430277267 2.54466085385067 0.9872150338132176 0.07507974750518859 0.1104357787958161 0.17196022514804196 0.058946353021023905 0.15441627995560153 1.2550861123678412e-07 6.901326475901516 1.6017936108229434 up DYVAPTANLDQKDK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYVAPTANLDQKDK 14 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 9218900.0 2195500.0 1819900.0 5203500.0 True False 3007235.6811566013 1739490.8003954892 3974540.4694464426 1.0 0.5784351427110197 1.3216591218144265 21.520006507642393 -6.75283894687417 1.6392968855227785 0.7529587379243715 1.3234637142387342 0.6610681617961803 0.17717573702879694 0.2951421501004359 1.561312267399278 0.08534736859113223 0.20658990972619917 1.766692856998557e-07 6.75283894687417 0.5705049763143627 DYVAPTANLDQKDK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYVAPTANLDQKDK 14 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 18015500.0 4902800.0 9686200.0 3426500.0 True False 4076895.4308669264 9634018.518039832 4142965.307654038 1.0 2.3630771702160676 1.0162059287287293 21.959039522642065 -6.643396389181734 2.0320040068676026 1.8890671461734772 1.0218184366403034 0.1677872004850317 0.5827271625084943 0.524887323736183 4.1461538159228475 0.2331878352972479 0.6453759287399672 2.273021851607772e-07 6.643396389181734 -0.8672487095331738 DYVAPTANLDQKDK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYVAPTANLDQKDK 14 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 38242600.0 6461800.0 15103800.0 16677000.0 True False 8364927.481120676 14263260.252692752 13641957.120470306 1.0 1.705126587753975 1.6308518096851032 22.995921602345593 -10.26398354785839 4.754883506688822 0.9997886039096064 1.667989198720903 0.9908125157275146 0.030322551175886277 6.797347296294929e-05 1.052160226832087e-05 0.029368813922165823 0.009786561309229192 5.44523280330928e-11 10.26398354785839 0.6682005948112966 DYVLNCSILNPLLTLLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYVLNCSILNPLLTLLTK 18 0 O60684;Q5TFJ7 O60684 KPNA6 Importin subunit alpha-7 0 717580000.0 339820000.0 204680000.0 173080000.0 False True 515531784.16974384 168153254.82786086 138870662.13634104 1.0 0.3261743698279809 0.2693736184665901 28.94148613615977 -13.999999999999998 0.35036040942326674 9.304983728272196 0.26156352236497904 0.999755395398078 0.00518997934756684 20.695793058006178 0.19056766539333447 127.94102036851791 0.01692643828299653 1.0000000000000041e-14 13.999999999999998 -9.043420205907218 DYVLNCSILNPLLTLLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYVLNCSILNPLLTLLTK 18 0 O60684;Q5TFJ7 O60684 KPNA6 Importin subunit alpha-7 0 482347000.0 339820000.0 20497000.0 122030000.0 False True 439903688.85363674 19356323.931688942 99821792.13353667 1.0 0.044001276693383475 0.22691737910556378 28.71261245825222 -10.218787939474034 6.002009571247806 1.0000176987732365 0.13545932790087745 0.9675172346483023 0.0746751861081025 1.7685881810800643e-05 2.301933537679962e-06 0.07230541401439745 0.024101312680965884 6.04243601895739e-11 10.218787939474034 -0.8645583708723591 DYVQK(ub)AQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYVQKAQTK 9 1 P35579;P35579-2;Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4;M0QY43;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;Q7Z406;P35580 MYH9;MYH14;MYH10 Myosin-9;Myosin-14;Myosin-10 1 2656950.0 557800.0 905350.0 1193800.0 True False 731281.2017428833 770275.3090266603 1070277.0277382082 1.0 1.0533229996762412 1.4635642557027126 19.480066751133908 -6.930829554793572 0.7399442612237137 0.993949857771064 1.549593930742814 0.9966989626716346 0.011899155935153968 0.09220899245725106 0.07558462631293243 0.010894768298469254 0.03695175275084084 1.1726555010109526e-07 6.930829554793572 0.5556440729717499 DYVQK(ub)AQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYVQKAQTK 9 1 P35579;P35579-2;Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4;M0QY43;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;Q7Z406;P35580 MYH9;MYH14;MYH10 Myosin-9;Myosin-14;Myosin-10 1 3572000.0 933160.0 971740.0 1667100.0 True False 903537.3465859598 1359760.849557154 1230436.4980720282 1.0 1.5049304322561177 1.3617992689746203 19.785224708753933 -9.962399745810494 4.761255718710165 0.9999953353531165 1.4333648504972847 0.9243741779048372 0.05843305280226801 40437473.49003743 25565871.98522292 2416.0860761150525 0.02138430811155616 1.0904361837681028e-10 9.962399745810494 0.4333695151441682 DYVQK(ub)AQTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 DYVQKAQTK 9 1 P35579;P35579-2;Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4;M0QY43;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;Q7Z406;P35580 MYH9;MYH14;MYH10 Myosin-9;Myosin-14;Myosin-10 1 10317900.0 1355400.0 2424300.0 6538200.0 True False 2056240.8930129784 1991664.7238576466 5245921.904205141 1.0 0.9685950370042932 2.551219520062346 20.97157785856276 -6.902373462972287 0.9461349427399179 0.938416460283168 2.7255916599726544 0.9877107561942644 0.081897210968405 0.10967944913631107 0.16772786488514801 0.06461854500129688 0.17022085077101604 1.2520640241127057e-07 6.902373462972287 1.7871751996894862 up DYVQK(ub)AQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYVQKAQTK 9 1 P35579;P35579-2;Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4;M0QY43;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;Q7Z406;P35580 MYH9;MYH14;MYH10 Myosin-9;Myosin-14;Myosin-10 1 3083290.0 557800.0 850790.0 1674700.0 True False 764033.7339782057 813199.2846137028 1279170.3515291556 1.0 1.0643499736320536 1.6742328180572774 19.5432768126568 -6.927085042328281 0.7703316480729613 0.9896552105129545 1.7906296711738034 0.9959340397834854 0.019372212741733494 0.09417918706210825 0.08530014725841194 0.017352324502969106 0.056093992904108075 1.1828099185233597e-07 6.927085042328281 0.800974460660849 DYVQK(ub)AQTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYVQKAQTK 9 1 P35579;P35579-2;Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4;M0QY43;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;Q7Z406;P35580 MYH9;MYH14;MYH10 Myosin-9;Myosin-14;Myosin-10 1 3869260.0 933160.0 1521600.0 1414500.0 True False 775963.885997346 1513402.838786048 1710265.4100909487 1.0 1.950352156970388 2.2040528444087903 19.56562998418821 -10.583780970716255 0.2753081958728482 1.4659290737664337e-14 2.3058971501157464 0.9991212364946477 0.015363065674979666 2.228555944543215 0.13638133526818066 1.622402689278179 0.10159511137324934 2.6074682522026225e-11 10.583780970716255 2.3058971501157317 DYVQK(ub)AQTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 DYVQKAQTK 9 1 P35579;P35579-2;Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4;M0QY43;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;Q7Z406;P35580 MYH9;MYH14;MYH10 Myosin-9;Myosin-14;Myosin-10 1 7322200.0 1355400.0 1112200.0 4854600.0 True False 1754592.0189283118 1050305.0922976246 3971112.6124024163 1.0 0.5986035961448981 2.2632683664137114 20.74270418065521 -6.843030563531935 1.2683034495385461 0.7864823133376493 2.3213687945949615 0.9295312768358023 0.1882928132825844 0.1652893022717375 0.5151746590257849 0.11635201889608121 0.26830181196548736 1.4353884141484937e-07 6.843030563531935 1.5348864812573122 up DYYINIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYYINIR 7 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 26948400.0 7769000.0 6775400.0 12404000.0 False True 10185234.23510301 5764536.7303023515 11120553.067569725 1.0 0.5659699715530452 1.0918308613112868 23.279975823301367 -6.687467977580323 1.8752235562496713 0.7272483081029457 1.0899686726987738 0.3586538438552953 0.18365964005235938 0.42215149423117526 2.8760767433415992 0.07840557079786845 0.20484187329888326 2.0536764473647476e-07 6.687467977580323 0.3627203645958281 DYYINIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYYINIR 7 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 14877100.0 3008000.0 1353100.0 10516000.0 False True 2912512.686495955 1893399.8863232825 7761544.126762313 1.0 0.65009154985046 2.6648962467182344 21.47383290328163 -6.862103492780443 1.1749777037945528 0.80897125831438 2.7664954779535 0.9561513885542796 0.18406292122890036 0.14465533397090885 0.37828093276549196 0.12206741341707879 0.2856669323902967 1.373714578538219e-07 6.862103492780443 1.9575242196391198 up DYYINIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYYINIR 7 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 22339000.0 7769000.0 7265500.0 7304500.0 False True 10641409.249330726 6944486.186204424 5579327.540899695 1.0 0.6525908386279934 0.5243034461108239 23.34318588482426 -13.99999999987515 0.13842592544456472 2.657351599367474 0.3624895106250707 0.9996092828148343 0.003972141449890096 11.932766464285061 0.11645145374607055 5.346946194294623 0.14451250395213142 1.0000000002874765e-14 13.99999999987515 -2.2948620887424034 DYYINIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYYINIR 7 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 9094500.0 3008000.0 3316100.0 2770400.0 False True 2501285.2769943154 3298235.511105689 3349677.831117682 1.0 1.3186162895697502 1.3391826441895676 21.254238178715905 -12.104972986343448 0.42424443673812184 4.1370733722117023e-10 1.3398477343589361 0.9997980943435062 0.002206304944734063 6.285955703109234 0.21437206397127062 5.610487456591777 0.004935129649774695 7.852844787615692e-13 12.104972986343448 1.3398477339452288 DYYK(ub)ILGVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYYKILGVDK 10 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 7266000.0 2375000.0 2215700.0 2675300.0 True False 3113647.999532716 1885126.1967309539 2398485.6192896874 1.0 0.6054397276165663 0.7703136705400362 21.57017442509863 -10.16373746710983 5.303443995238521 1.0000114618490008 0.6878766990781794 0.826943218524149 0.0673095053409697 9.122356932914611e-06 1.438474774586654e-06 0.06517454092516166 0.02172404943552467 6.859027323190713e-11 10.16373746710983 -0.3121347627708214 DYYK(ub)ILGVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 DYYKILGVDK 10 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 13538500.0 4958000.0 4421100.0 4159400.0 True False 4800611.003871986 6186468.285731928 3069928.3606746993 1.0 1.2886835198149078 0.6394870065911641 22.194786607690713 -6.785843300351894 1.5131295356158323 1.1622216736837374 0.6333724359981863 0.7875056755291969 0.12242173333174756 0.24160353604437887 1.0928596636051482 0.0637021119587287 0.14959169051657636 1.6374072147512233e-07 6.785843300351894 -0.5288492376855511 DYYK(ub)ILGVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 DYYKILGVDK 10 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 7177800.0 2375000.0 2447600.0 2355200.0 True False 3253101.681961706 2339456.938869169 1798950.2668665852 1.0 0.7191465768934757 0.5529954003103189 21.633384486621523 -10.786470772675932 0.08431161618224013 1.9591077974394366 2.426467277930257e-07 0.9999452376659862 0.0013651736481439043 2.9362904446247287 0.049097871922137624 0.8936914844101939 0.33894645381551464 1.635043183218614e-11 10.786470772675932 -1.9591075547927088 DYYK(ub)ILGVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 DYYKILGVDK 10 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 14435000.0 4958000.0 5431600.0 4045400.0 True False 4122796.6766415583 5402338.892711809 4891274.436183755 1.0 1.3103578265985625 1.1863972006905277 21.97519188312499 -10.113512146860451 4.251723870172137 0.9999586122248615 1.248377513676043 0.8425935965941383 0.0506067137190582 7304462.473948566 8687509.266031913 2273.0581750007236 0.017324023821553944 7.699949079296696e-11 10.113512146860451 0.24841890145118162 DYYQTLGLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 DYYQTLGLAR 10 0 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 0 6732200.0 1562600.0 2036900.0 3132700.0 False True 2048583.7322399253 1733002.4597740113 2808558.254980308 1.0 0.8459514895586636 1.370975572430923 20.966195430957875 -6.82816464917443 1.336246854724999 0.9175782970191286 1.3845657700655307 0.9021226053413666 0.0689386386814356 0.1830888266043375 0.6400297065448637 0.040516507001507954 0.09324204155184052 1.4853724030206074e-07 6.82816464917443 0.4669874730464021 EAAASGLPLMVIIHK ddPTM_RPMI8226_Bortezomib_1h_R1 2 EAAASGLPLMVIIHK 15 0 O95881 O95881 TXNDC12 Thioredoxin domain-containing protein 12 0 38167300.0 10574200.0 14989100.0 12604000.0 False True 13862878.600698456 12752784.707054168 11299858.986105198 1.0 0.9199232767148118 0.8151163486013557 23.72472352570882 -6.967423890893291 0.313683348862793 1.0154599086656195 0.7162303730897812 0.9999547373272923 0.0005092796182475206 0.07714782860389537 0.01200819925976289 0.0016313910485714462 0.00927224264846224 1.0778941356055121e-07 6.967423890893291 -0.2992295355758383 EAAASGLPLMVIIHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAAASGLPLMVIIHK 15 0 O95881 O95881 TXNDC12 Thioredoxin domain-containing protein 12 0 27403800.0 10545000.0 5696800.0 11162000.0 False True 10210254.74704116 7971561.94841954 8238337.347177727 1.0 0.7807407499533375 0.8068689323902641 23.283515526285044 -10.69289225959037 5.734166527170231 1.0035749628991164 0.7938048411718017 0.9881006281364985 0.010666785812803262 0.0004948573874477343 2.6503309705964843e-05 0.010483881050863893 0.0034426903175457098 2.0281858124144762e-11 10.69289225959037 -0.20977012172731468 EAAASGLPLMVIIHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAAASGLPLMVIIHK 15 0 O95881 O95881 TXNDC12 Thioredoxin domain-containing protein 12 0 28858400.0 5047900.0 14624000.0 9186500.0 False True 7658033.350922407 12014232.942166476 7370784.248414023 1.0 1.568840509256775 0.9624904868723528 22.86854251249809 -8.725818666489607 18.326219306917693 1.0000117786179028 1.2656654980645654 0.20379261907098078 0.24754136015458006 0.0 0.0 0.23968089130184594 0.07989363043394863 1.8801016627642917e-09 8.725818666489607 0.2656537194466626 EAAASGLPLMVIIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EAAASGLPLMVIIHK 15 0 O95881 O95881 TXNDC12 Thioredoxin domain-containing protein 12 0 44173600.0 10574200.0 13934100.0 19665300.0 False True 14483767.4970103 13318445.388093175 15020761.159566652 1.0 0.9195428876390299 1.037075551141455 23.787933587231713 -6.722437906025867 1.7504184360729098 0.9511786302085075 1.0369193238577885 0.5240222177773335 0.03384699047878075 0.35061799640135705 2.100748777799957 0.015345315419429031 0.03841427401117463 1.8947944063646128e-07 6.722437906025867 0.08574069364928105 EAAASGLPLMVIIHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAAASGLPLMVIIHK 15 0 O95881 O95881 TXNDC12 Thioredoxin domain-containing protein 12 0 22146500.0 10545000.0 5919600.0 5681900.0 False True 8768634.722707788 5887709.939851396 6869959.019862679 1.0 0.6714511581380196 0.7834696320593464 23.06392080171932 -10.912031068627437 10.908226457557761 1.029911941014427 0.7274603950987328 0.8875466221103789 0.04573135047875249 0.023610394090600614 0.00019040472509555535 0.03142592698611889 0.014759729900315245 1.2245285956109508e-11 10.912031068627437 -0.30245154591569423 EAAASGLPLMVIIHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAAASGLPLMVIIHK 15 0 O95881 O95881 TXNDC12 Thioredoxin domain-containing protein 12 0 16175300.0 5047900.0 6189000.0 4938400.0 False True 6534606.058984977 5844576.709431765 4039661.8722630343 1.0 0.8944038334790766 0.6181951652171235 22.63966883459054 -6.954485001667989 0.507223832994812 1.0052017107683686 0.49533681890298514 0.9995078589027846 0.003571106707170937 0.08173325398297873 0.02888439643960055 0.0041332051109635014 0.022792230621720637 1.1104908854027588e-07 6.954485001667989 -0.5098648918653834 EAAEEEGEPEVK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAAEEEGEPEVKK 13 1 O95551;O95551-2;O95551-3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 28012600.0 4038200.0 21296800.0 2677600.0 True False 5294119.305984431 18119400.454276215 2400547.6373528494 1.0 3.422552346675336 0.4534366338588723 22.335959276475702 -6.689755880804394 1.867072931480519 2.519109036586331 0.46366600570215516 0.3693881903004338 1.0246161729061036 0.41718730513166946 2.8193876261587842 0.439028713567266 1.1437018749400327 2.042885938844096e-07 6.689755880804394 -2.055443030884176 EAAEEEGEPEVK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAAEEEGEPEVKK 13 1 O95551;O95551-2;O95551-3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 82184600.0 27614000.0 23763800.0 30806800.0 True False 26737408.68513938 33252809.26657988 22737574.89581031 1.0 1.243681078378465 0.8504030874333692 24.672356314450045 -6.739111925431115 1.6899054628433825 1.1451393336140572 0.8502156604955099 0.6009436735007105 0.10238695804907462 0.31943733656737033 1.790844514720969 0.04793685201076578 0.1177495243458542 1.8234257124435123e-07 6.739111925431115 -0.2949236731185473 EAAEEEGEPEVK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAAEEEGEPEVKK 13 1 O95551;O95551-2;O95551-3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 36563000.0 5454200.0 28909300.0 2199500.0 True False 8274420.155431168 23750209.545608174 1764767.8609249012 1.0 2.8703170856049653 0.21327994321953087 22.980226785389743 -6.7175327002923 1.7681693944315204 2.140845754312495 0.2179642976603396 0.5009066980445094 0.7872805778421743 0.36010777591784743 2.198909185263724 0.3537217422789007 0.8905691634703484 1.9163167678380945e-07 6.7175327002923 -1.9228814566521553 EAAEEEGEPEVK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAAEEEGEPEVKK 13 1 O95551;O95551-2;O95551-3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 10440400.0 4038200.0 3552400.0 2849800.0 True False 5531231.668251693 3395443.221784132 2176735.933473333 1.0 0.6138674757149271 0.39353548432393787 22.399169337998593 -9.534521471594955 0.138624974532216 1.625922670522172 7.737555787443028e-10 0.9998351155073139 0.0032185676803007457 0.9872822800019843 0.05528630749197965 0.4368539056796882 0.19900839032670967 2.9206433595203334e-10 9.534521471594955 -1.6259226697484166 EAAEEEGEPEVK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAAEEEGEPEVKK 13 1 O95551;O95551-2;O95551-3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 62564200.0 27614000.0 32028700.0 2921500.0 True False 22962264.507620007 31856155.035900846 3532372.142510217 1.0 1.3873263686745447 0.15383378853326957 24.45276158988432 -6.822305171705131 1.3618771333715025 1.208293298377197 0.12555178869997832 0.8896023592196408 0.17113246891465173 0.1905025754248731 0.6936314532423847 0.09873027094649922 0.22742885531704968 1.5055487696471564e-07 6.822305171705131 -1.0827415096772186 down EAAEEEGEPEVK(ub)KR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAAEEEGEPEVKKR 14 2 O95551;O95551-2;O95551-3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 1599500.0 1599500.0 0.0 0.0 True False 1548724.7480220345 0.0 0.0 1.0 0.0 0.0 20.562649328719665 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 EAAEEEGEPEVK(ub)KR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAAEEEGEPEVKKR 14 2 O95551;O95551-2;O95551-3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 9266200.0 2134200.0 3778900.0 3353100.0 True False 3237737.430919513 3104525.770319541 2690358.3152840626 1.0 0.958856558494263 0.8309377683291645 21.62655456223153 -6.950645223550279 0.5517177433532925 1.0017513320182685 0.78201585792431 0.9992509230913393 0.00197019957903983 0.08322774942928497 0.03489853600951403 0.002133719361135015 0.010615425845044706 1.1203527292119233e-07 6.950645223550279 -0.21973547409395844 EAAEEEGEPEVK(ub)KR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAAEEEGEPEVKKR 14 2 O95551;O95551-2;O95551-3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 7469000.0 2134200.0 2485800.0 2849000.0 True False 2762763.9713714113 2347463.0448061824 2330511.233208608 1.0 0.8496791869053232 0.8435433708264853 21.39768088432398 EAAENSLVAYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAAENSLVAYK 11 0 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 0 47295700.0 4454700.0 19630000.0 23211000.0 False True 5840154.839376172 16701280.517140709 20809348.375633772 1.0 2.8597324859497544 3.563150112961143 22.47757518894981 -9.458323833044666 0.2929195696612067 1.0248250801649167e-21 3.861609605312765 0.998758872207355 0.038094270414625354 0.8437453576470534 0.11648805912653701 1.0775809773557448 0.25322623932779836 3.4807767303630097e-10 9.458323833044666 3.861609605312765 EAAENSLVAYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAAENSLVAYK 11 0 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 0 31066900.0 9492300.0 3132600.0 18442000.0 False True 9190972.13232233 4383463.516293188 13611486.951859139 1.0 0.47693143371392155 1.4809627051300671 23.13178603326579 -6.765160174112312 1.5932404178630861 0.698122116839618 1.485569196501042 0.711580775870586 0.2201967869760007 0.27434455930945895 1.3736096987437783 0.10899410612343598 0.26059277525180324 1.717274914418871e-07 6.765160174112312 0.787447079661424 EAAENSLVAYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAAENSLVAYK 11 0 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 0 39088700.0 4454700.0 14449000.0 20185000.0 False True 6101722.973740982 13810595.403546588 15417718.72312415 1.0 2.2633927274281476 2.5267811713961685 22.5407852504727 -10.408174524716877 0.3358096927796279 2.2198167219684766e-24 2.585449651375139 0.9990680578351311 0.020343154652187428 1.8940803516963012 0.15903225554334102 1.7345373191322748 0.08204430781585553 3.906838648014237e-11 10.408174524716877 2.585449651375139 EAAENSLVAYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAAENSLVAYK 11 0 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 0 14281300.0 9492300.0 2787100.0 2001900.0 False True 7893268.030190542 2772085.3391039665 2420488.0342602083 1.0 0.3511961494910808 0.30665220349824834 22.912191308700066 -13.915617731691558 0.3810212692768512 9.999999995028013 0.30277309390228674 0.9998074115255504 0.004397405056538079 22.59107450791473 0.20118137981548131 166.40676298299923 0.012041676021082276 1.2144573519538377e-14 13.915617731691558 -9.697226901125726 EAAGK(ub)SSGPTSLFAVTVAPPGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAAGKSSGPTSLFAVTVAPPGAR 23 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;A0A1W2PP35;A0A1W2PP22 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 14483200.0 5061300.0 6694100.0 2727800.0 True False 6635413.313698921 5695366.373397423 2445553.4229052523 1.0 0.8583288039705446 0.36856082768142967 22.66175490184539 -6.948227070330381 0.5779800185880487 1.0058997752447238 0.19684905932219443 0.9990547075049644 0.008317484568813295 0.08420557142370431 0.0389696162293529 0.008733712820294146 0.04089083024103452 1.1266082564303581e-07 6.948227070330381 -0.8090507159225294 down EAAGK(ub)SSGPTSLFAVTVAPPGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAAGKSSGPTSLFAVTVAPPGAR 23 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;A0A1W2PP35;A0A1W2PP22 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 26549000.0 10762000.0 8963000.0 6824000.0 True False 10420366.200820975 12541972.64142754 5036589.684388168 1.0 1.2036019080058253 0.48334094861189786 23.312902643058766 -6.831204293378194 1.3225636785959625 1.108702048986678 0.46348359964770086 0.9082563092776308 0.0918254843987888 0.17932800298779322 0.613049430176398 0.05450748800623864 0.1254314654744659 1.4750125199076849e-07 6.831204293378194 -0.645218449338977 down EAAGK(ub)SSGPTSLFAVTVAPPGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAAGKSSGPTSLFAVTVAPPGAR 23 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;A0A1W2PP35;A0A1W2PP22 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 25883500.0 10762000.0 12551000.0 2570500.0 True False 8949079.83743778 12483385.271821558 3107979.6653508497 1.0 1.3949350657928299 0.34729600381358294 23.093307918493043 -6.804564193020242 1.4371393361632538 1.216654049776387 0.33113679827404613 0.8452070243933733 0.16996129783111802 0.21429494149392614 0.8732484227957525 0.09301697557775457 0.21575688381860064 1.568324066737147e-07 6.804564193020242 -0.8855172515023408 down EAALAEVADEK(ub)MLSGLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAALAEVADEKMLSGLTK 18 1 E9PHA2;Q15003;Q15003-2;H7C415 E9PHA2 NCAPH Condensin complex subunit 2 1 6241200.0 1333900.0 2559300.0 2348000.0 True False 1748755.817505973 2177462.4160732664 2105051.4836063953 1.0 1.2451494910128178 1.2037423764562862 20.737897426069775 -10.108752450602395 4.616586197520181 0.9999827579136938 1.2244459337394866 0.9751090789535489 0.0169043837476044 2029407.3126029104 4452687.084181856 214.41605091402886 0.005786820704947143 7.78480161055662e-11 10.108752450602395 0.22446317582579278 EAALGAGFSDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAALGAGFSDK 11 0 P55084-2;P55084;B5MD38;F5GZQ3;C9JEY0;C9JE81 P55084-2 HADHB Trifunctional enzyme subunit beta, mitochondrial;3-ketoacyl-CoA thiolase 0 12514500.0 2456300.0 4166400.0 5891800.0 False True 3220233.0868430347 3544789.360499999 5282173.054136359 1.0 1.1007865781464732 1.640307677018111 21.618733686565367 -6.938295454258445 0.6752381859148362 0.9937283920557226 1.7787811856198834 0.9979319708453669 0.012783905467898092 0.08855296162146736 0.05821653300800217 0.012288967867771823 0.0467949701736237 1.1526688205433232e-07 6.938295454258445 0.7850527935641608 EAALGAGFSDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAALGAGFSDK 11 0 P55084-2;P55084;B5MD38;F5GZQ3;C9JEY0;C9JE81 P55084-2 HADHB Trifunctional enzyme subunit beta, mitochondrial;3-ketoacyl-CoA thiolase 0 7085200.0 1759100.0 736700.0 4589400.0 False True 1703258.3333826594 1030868.1518397486 3387298.460951212 1.0 0.6052330005586712 1.9887167991857468 20.69986583465489 -6.830438221298503 1.3259199934102002 0.7891265385651715 2.026288596407438 0.9067572183415511 0.1776859857738567 0.18026830810907038 0.619660285546548 0.10521372565989132 0.24212751289715811 1.47761665866968e-07 6.830438221298503 1.2371620578422666 EAALGAGFSDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAALGAGFSDK 11 0 P55084-2;P55084;B5MD38;F5GZQ3;C9JEY0;C9JE81 P55084-2 HADHB Trifunctional enzyme subunit beta, mitochondrial;3-ketoacyl-CoA thiolase 0 5909800.0 2456300.0 0.0 3453500.0 False True 3364460.489011594 0.0 2637854.42706511 1.0 0.0 0.7840348952470696 21.68194374808826 -10.82865628001861 9.382080739861538 1.0150082621968073 0.3920174476240475 0.44499042136913647 0.32008090564863007 0.09316915275894888 0.0017015328887435904 0.2873598393028097 0.1033056680846777 1.4836918803740914e-11 10.82865628001861 -0.6229908145727598 EAALHIFWNFPGIFGNQQQHYLDVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAALHIFWNFPGIFGNQQQHYLDVIK 26 0 O00410;O00410-3;H0Y8C6;O00410-2;H0Y3V4 O00410 IPO5 Importin-5 0 695417000.0 179536000.0 207989000.0 307892000.0 False True 272369237.83973604 170871737.92452562 247037011.24614233 1.0 0.6273532917291773 0.9069930701627201 28.020988529548035 -9.890571408894868 6.831087717020342 1.0000000061436856 0.7671731809459456 0.4803269999023341 0.11416246149119884 1.0741561890367322e-08 1.6878633288057854e-09 0.11053733132362766 0.03684577600978653 1.2865556936442747e-10 9.890571408894868 -0.23282682519774 EAALHIFWNFPGIFGNQQQHYLDVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAALHIFWNFPGIFGNQQQHYLDVIK 26 0 O00410;O00410-3;H0Y8C6;O00410-2;H0Y3V4 O00410 IPO5 Importin-5 0 324869500.0 179536000.0 8869500.0 136464000.0 False True 232412891.18364576 8375904.528082897 111628952.23888345 1.0 0.036038898210101894 0.4803044773909618 27.792114851640484 -9.688593775167893 9.103518469981914 0.9999999390503366 0.2581764262709241 0.7880268694241805 0.18137066325379317 0.0 0.0 0.17561138962406936 0.05853712987468977 2.048359709510645e-10 9.688593775167893 -0.7418235127794125 EAALILGVSPTANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAALILGVSPTANK 14 0 Q96DA6-2;Q96DA6 Q96DA6-2 DNAJC19 Mitochondrial import inner membrane translocase subunit TIM14 0 7847600.0 2856100.0 1707200.0 3284300.0 False True 2765434.6688500997 2388893.86293039 2424043.3031119662 1.0 0.8638402815437763 0.876550558368429 21.399074829281 -10.58275500039357 6.353858964802019 1.00028985055426 0.8701954199561026 0.9928603005088185 0.005188948784986899 2.1352752968484104e-05 1.4021923771278404e-06 0.005035307379479711 0.001674726019048126 2.6136353750941535e-11 10.58275500039357 -0.13009443059815728 EAALILGVSPTANK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAALILGVSPTANK 14 0 Q96DA6-2;Q96DA6 Q96DA6-2 DNAJC19 Mitochondrial import inner membrane translocase subunit TIM14 0 19636700.0 2081700.0 12080000.0 5475000.0 False True 3158091.092655393 9924229.618529202 4392863.850222255 1.0 3.1424773153660652 1.3909870619117064 21.590621354527023 -6.596252878003676 2.2046972254368713 2.4443101744748525 1.3964131538847266 0.010006372616443326 0.9269208453434098 0.6513799256389525 5.977928573949574 0.3497025062110173 1.0319368252281544 2.5336529229106706e-07 6.596252878003676 -1.047897020590126 EAALILGVSPTANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAALILGVSPTANK 14 0 Q96DA6-2;Q96DA6 Q96DA6-2 DNAJC19 Mitochondrial import inner membrane translocase subunit TIM14 0 11261300.0 3908600.0 3362900.0 3989800.0 False True 5353715.045943381 3214315.95837683 3047491.4125103117 1.0 0.6003898098409968 0.5692292896349532 22.352108922209343 -13.999999999999998 0.36176215704771186 6.286353078552987 0.5655714132734543 0.9997764641876704 0.002932440577290688 21.88798529915935 0.1945240746705031 89.40400204038527 0.008940249636958896 1.0000000000000041e-14 13.999999999999998 -5.720781665279533 EAALQGTK(ub)TEAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAALQGTKTEAER 13 1 Q8TBK2-2;Q8TBK2;J3QT10 Q8TBK2-2 SETD6 N-lysine methyltransferase SETD6 1 6458400.0 1323200.0 0.0 5135200.0 True False 1734728.0138870273 0.0 4603858.764316684 1.0 0.0 2.653936944271026 20.72627805127687 -6.80463611237712 1.4370394931245503 0.451465631475785 2.6948524414498274 0.845346849604154 0.4303731066087185 0.21420101428765145 0.8727650596973479 0.23556099036188743 0.5463234687810579 1.5680643730864124e-07 6.80463611237712 2.2433868099740426 EAALQGTK(ub)TEAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAALQGTKTEAER 13 1 Q8TBK2-2;Q8TBK2;J3QT10 Q8TBK2-2 SETD6 N-lysine methyltransferase SETD6 1 23102000.0 0.0 4655000.0 18447000.0 True False 0.0 3824278.880318996 14800942.36439267 0.0 EAALQGTK(ub)TEAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAALQGTKTEAER 13 1 Q8TBK2-2;Q8TBK2;J3QT10 Q8TBK2-2 SETD6 N-lysine methyltransferase SETD6 1 30725900.0 0.0 4691900.0 26034000.0 True False 0.0 4430791.640488432 21296079.131397996 0.0 EAALSTALSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAALSTALSEK 11 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 28503300.0 3091300.0 11244000.0 14168000.0 False True 4052724.236191789 9566439.028768728 12702031.269052574 1.0 2.3604959210740657 3.134195797389919 21.950460581221712 -8.817735196629904 0.2108586205753279 2.047290358031423e-20 3.9061263295695583 0.9995408686686558 0.01890301951326741 0.34100451227068573 0.06498475597577087 0.6196787372185462 0.38265153628176185 1.5214749393708117e-09 8.817735196629904 3.9061263295695583 EAALSTALSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAALSTALSEK 11 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 17279800.0 4046500.0 1531300.0 11702000.0 False True 3918046.0724421125 2142756.0756240054 8636895.147524975 1.0 0.546894047697716 2.204388357827965 21.901702931731347 -6.833856446375269 1.3106338280642258 0.758465157760327 2.2525939501466254 0.9133629509446787 0.20587897664118054 0.17609931701235446 0.59023299098527 0.123284897831805 0.28372267086845426 1.4660323497123705e-07 6.833856446375269 1.4941287923862985 up EAALSTALSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAALSTALSEK 11 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 21931900.0 3091300.0 6025600.0 12815000.0 False True 4234237.149241363 5759369.0680054175 9788360.933209604 1.0 1.3601904817818975 2.311717692752131 22.013670642744604 -6.954269382405827 0.5098241045728205 0.982462573480118 2.7311779895845696 0.9994951327416622 0.012433310462816996 0.08181533611156319 0.02920790052604188 0.01432509054742818 0.07853089000988477 1.1110423606914308e-07 6.954269382405827 1.7487154161044516 up EAANAMK(ub)LER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAANAMKLER 10 1 O60488-2;O60488 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 6186900.0 1575900.0 1501300.0 3109700.0 True False 2390755.513722264 1233381.2852895628 2495066.431970074 1.0 0.5158960329528892 1.0436309432934878 21.18903517232439 -6.665502863758185 1.953652789864403 0.6898020948136316 1.0414443682151444 0.2591103774366149 0.20585421913404037 0.47154578485559534 3.465419202181345 0.08496679281707123 0.22832156649053556 2.160215790163529e-07 6.665502863758185 0.3516422734015128 EAANAMK(ub)LER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAANAMKLER 10 1 O60488-2;O60488 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 3500140.0 836820.0 1913600.0 749720.0 True False 695852.9074116967 1903291.05698014 906482.9856863798 1.0 2.7351916428137746 1.302693394007859 19.40842284922482 -6.598787140145152 2.194591824078236 2.1678073526449335 1.3071947614443025 0.017287508069863566 0.7502188558051592 0.6441160969025432 5.860677947369783 0.2839041853309807 0.8350288545000821 2.518911213990886e-07 6.598787140145152 -0.860612591200631 EAAPDAGAEPITADSDPAYSSK(ub)VLLLSSPGLEELYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAAPDAGAEPITADSDPAYSSKVLLLSSPGLEELYR 36 1 Q8N163;Q8N163-2;E5RHJ4 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 1 51211000.0 19150000.0 14643000.0 17418000.0 True False 29051950.05252958 12029842.24371882 13975324.665419405 1.0 0.41408037057641056 0.48104601034182765 24.792131669035566 -10.30613889358591 5.67612051137911 1.000063656587062 0.4475631904608455 0.9890996570585474 0.027338607954068745 2.2025337605196122e-05 2.692434096469673e-06 0.02647352472552816 0.00882349777621415 4.941526246369294e-11 10.30613889358591 -0.5525004661262165 EAAPDAGAEPITADSDPAYSSK(ub)VLLLSSPGLEELYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAAPDAGAEPITADSDPAYSSKVLLLSSPGLEELYR 36 1 Q8N163;Q8N163-2;E5RHJ4 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 1 15238000.0 6584200.0 3497700.0 5156100.0 True False 5475054.029516614 3478857.1958609065 6234216.670887194 1.0 0.6354014366079326 1.1386584748347415 22.38444177106649 -6.712387654002943 1.7868703254100273 0.7764005335060237 1.1375526209787707 0.4763744396456596 0.15358362921699067 0.37028626594290315 2.306151954542347 0.06836440142008177 0.17316525422790854 1.939154203542289e-07 6.712387654002943 0.3611520874727471 EAAPDAGAEPITADSDPAYSSK(ub)VLLLSSPGLEELYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAAPDAGAEPITADSDPAYSSKVLLLSSPGLEELYR 36 1 Q8N163;Q8N163-2;E5RHJ4 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 1 53061000.0 19150000.0 11656000.0 22255000.0 True False 24790052.502934348 11007333.35355254 18204818.35558355 1.0 0.44402218802278154 0.7343598144226875 24.563257991128015 -10.134336176380712 5.14061565769689 1.0000145745396853 0.5891910012222292 0.7274751201352951 0.11852983963688705 1.9799403315286575e-05 3.334291128249976e-06 0.11477009217547786 0.038255341244934474 7.339455195387248e-11 10.134336176380712 -0.4108235733174561 EAAQEAVK(ub)LCDSYEIRPGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAAQEAVKLCDSYEIRPGK 19 2 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 54314100.0 12270100.0 14352000.0 27692000.0 True False 18614638.76446699 11790773.467312198 22218664.062165238 1.0 0.6334140359370983 1.193612422099637 24.14993428374403 -6.730172823915407 1.7228851203413162 0.7794300307888509 1.1932722284802333 0.5599579971557331 0.15410149596436468 0.33590587308121167 1.953508670920541 0.07088288281263527 0.17583751652235619 1.861346281827656e-07 6.730172823915407 0.4138421976913824 EAAQEAVK(ub)LCDSYEIRPGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAAQEAVKLCDSYEIRPGK 19 2 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 47588100.0 12270100.0 10982000.0 24336000.0 True False 15883886.32983052 10370842.04604615 19907097.70844667 1.0 0.6529159067683159 1.2532888548226646 23.92106060583648 -6.749950770453467 1.649979609023356 0.7958993203516733 1.254480941410599 0.6487763555408289 0.14584678910163656 0.3001322890561226 1.6076021615424259 0.06982659737881464 0.16953200630252785 1.778480998717984e-07 6.749950770453467 0.45858162105892575 EAAQEAVK(ub)LYNNHEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAAQEAVKLYNNHEIR 16 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 86359700.0 26402000.0 38675000.0 21282700.0 True False 34613277.67733168 32904840.753969256 19080570.36207402 1.0 0.950642151278228 0.551250030116909 25.044822227065236 -6.9298847911440244 0.7477432149841077 1.0060997690093225 0.46949861760841266 0.9965154038236889 0.011860517489655288 0.09269797655749074 0.07797537135391555 0.010798044912367638 0.036161116191339285 1.1752092709853572e-07 6.9298847911440244 -0.5366011514009099 EAAQEAVK(ub)LYNNHEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAAQEAVKLYNNHEIR 16 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 97463800.0 36592000.0 40767000.0 20104800.0 True False 35430406.98944815 57045475.697096534 14838749.748928381 1.0 1.6100711378812487 0.41881397956697597 25.078484702015665 -6.767496363935564 1.584025358746437 1.3510391001846649 0.41273695511375375 0.7208935106466758 0.2569552041353334 0.27049924618229304 1.3390838168269823 0.12789232681883766 0.3051428942640339 1.7080620204890884e-07 6.767496363935564 -0.9383021450709111 EAAQEAVK(ub)LYNNHEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAAQEAVKLYNNHEIR 16 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 188181000.0 51629000.0 73419000.0 63133000.0 True False 78324967.58548565 60316805.82473471 50654734.87782307 1.0 0.7700840189803281 0.6467252581054354 26.222968931753684 -13.999999999998716 0.07688020287756406 2.2645934973098445 0.2561033371912756 0.9998992352281495 0.0014695195411951318 12.289733550306975 0.0770959853588848 2.6828814162306225 0.35618472875731677 1.0000000000029573e-14 13.999999999998716 -2.0084901601185687 EAAQEAVK(ub)LYNNHEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAAQEAVKLYNNHEIR 16 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 61880300.0 26402000.0 29589000.0 5889300.0 True False 36163532.88722229 28281660.14226176 4498368.6339407945 1.0 0.7820491496353377 0.12438963438580994 25.108032288588127 -7.150426418580735 0.6432966108330966 1.000349100417047 4.1758313017792886e-26 0.9978484155421958 0.01726398347562088 0.08196321755618179 0.05702844791586234 0.01661324447870453 0.051692936295216194 7.072510182879513e-08 7.150426418580735 -1.000349100417047 down EAAQEAVK(ub)LYNNHEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAAQEAVKLYNNHEIR 16 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 90599200.0 36592000.0 37496000.0 16511200.0 True False 30427869.30045746 37294001.605626695 19963615.5808368 1.0 1.2256527473997665 0.6560964024035907 24.85888997744994 -6.7992244643133 1.4592101147297392 1.1246254749762175 0.6483957551495108 0.8298470969332553 0.0966003377227857 0.22186831362575088 0.9327791517036268 0.052083090629852974 0.12117655920628334 1.5877259232385168e-07 6.7992244643133 -0.4762297198267067 EAAQEAVK(ub)LYNNHEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAAQEAVKLYNNHEIR 16 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 178931000.0 51629000.0 89541000.0 37761000.0 True False 66834758.259738795 84557964.63713507 30888885.460579216 1.0 1.2651794790447042 0.462167983619186 25.994095253846133 -6.817704916890348 1.3816830423307485 1.1432721871878024 0.4454721557249269 0.8790442081246208 0.1161843912820946 0.19647965782478571 0.7376273488638639 0.06608822750200387 0.15243062895802495 1.5215810228530969e-07 6.817704916890348 -0.6978000314628756 down EAAQK(ub)AVNSATGVPTV ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAAQKAVNSATGVPTV 16 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAS6;H0YB75;H0YAS7;H0YC10 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 5724700.0 1524100.0 2035500.0 2165100.0 True False 1998109.8594053953 1731811.3343168565 1941076.2211057113 1.0 0.8667247830067838 0.9714562049572908 20.93020447640954 -10.237547871274439 5.196333331575586 1.000008831679247 0.9190904940233601 0.44313369161026495 0.04275642396922194 4.375137951580654e-06 6.41920084382174e-07 0.04140324790692275 0.013799576498003788 5.7869819627208254e-11 10.237547871274439 -0.08091833765588696 EAAQK(ub)AVNSATGVPTV ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAAQKAVNSATGVPTV 16 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAS6;H0YB75;H0YAS7;H0YC10 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 8563100.0 2593300.0 3638800.0 2331000.0 True False 2510977.1110006487 5091791.816091314 1720441.1714989478 1.0 2.0278129154519395 0.6851680025125101 21.259817446999154 -6.702133047141181 1.8230915597422792 1.636885225433406 0.688974861029738 0.42778196404988944 0.43368490474397475 0.3911034102483877 2.5285979423885983 0.18966634266047327 0.48652255070640016 1.98548656567416e-07 6.702133047141181 -0.947910364403668 EAAQK(ub)AVNSATGVPTV ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAAQKAVNSATGVPTV 16 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAS6;H0YB75;H0YAS7;H0YC10 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 15527800.0 5353500.0 5384200.0 4790100.0 True False 8121650.893275045 4423347.443053396 3843334.635424589 1.0 0.5446364909277315 0.4732208618578986 22.953341584106063 -13.999999999998575 0.26077258426090877 4.346947009392271 0.4473114229398055 0.9995639143895303 0.004872381141899042 14.451344109134403 0.1615992749534086 25.50020259140917 0.031095267481161742 1.0000000000032804e-14 13.999999999998575 -3.8996355864524657 EAAQK(ub)AVNSATGVPTV ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAAQKAVNSATGVPTV 16 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAS6;H0YB75;H0YAS7;H0YC10 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 4915100.0 1524100.0 1786400.0 1604600.0 True False 2087600.9572538265 1707470.9411651758 1225626.5277743388 1.0 0.8179105950455685 0.5870980866892359 20.99341453793243 -6.967904219487435 0.304117772446789 1.0381213139464531 0.3596125111479801 0.9999611042199227 0.0010537110714897704 0.07698887656790057 0.01145196085441859 0.0037532036956591363 0.020612028740790336 1.07670264644217e-07 6.967904219487435 -0.678508802798473 EAAQK(ub)AVNSATGVPTV ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAAQKAVNSATGVPTV 16 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAS6;H0YB75;H0YAS7;H0YC10 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 7830200.0 2593300.0 3994100.0 1242800.0 True False 2156443.852669332 3972582.9905332224 1502663.7339420503 1.0 1.8421917109577421 0.696824882355269 21.04022272243343 -6.709658329420553 1.7963188029806711 1.5179435414037454 0.6995329078504194 0.46349115318641254 0.35491458247184154 0.3757815222598472 2.3634401334857604 0.15724028563491643 0.3996453816231545 1.9513791959613444e-07 6.709658329420553 -0.818410633553326 EAATLEVERPLPMEVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAATLEVERPLPMEVEK 17 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 0 24093300.0 3731700.0 9869600.0 10492000.0 False True 4892294.8378342055 8397094.15139947 9406388.486370647 1.0 1.716391679107554 1.9226945223388885 22.222079920913036 -10.94870320708251 0.2420193922387796 1.5644777715169522e-13 2.0313994683545205 0.9992397735044117 0.010902329795275716 2.891542238119963 0.12860903551526434 1.7228830502714994 0.09856886054831171 1.1253737814938026e-11 10.94870320708251 2.031399468354364 EAATLEVERPLPMEVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAATLEVERPLPMEVEK 17 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 0 25900700.0 3731700.0 11487000.0 10682000.0 False True 5111410.335400633 10979466.35757073 8159131.602695668 1.0 2.14803070720601 1.5962583841463698 22.285289982435927 -10.016695567062937 5.165978541924098 0.9999927413130468 1.8721445456800887 0.7691151173253583 0.22526010762796533 1.883216266926288e-05 3.5848180385929514e-06 0.21810897645509747 0.07270238711537882 9.622865883081753e-11 10.016695567062937 0.8721518043670419 EAAWAISNLTISGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAAWAISNLTISGR 14 0 O00629;O00505 O00629;O00505 KPNA4;KPNA3 Importin subunit alpha-3;Importin subunit alpha-4 0 10923300.0 3975000.0 1861600.0 5086700.0 False True 3848815.8008049936 2604946.5881157503 3754340.6722709984 1.0 0.6768176818362979 0.9754534554461569 21.87598319666307 -10.446253966384532 8.35731506713373 1.0000040961954675 0.8261355690077089 0.31126422363226447 0.12191754404757818 9.305143189665337e-06 6.166221733435356e-07 0.11804893388638536 0.03934871814223163 3.5788709096723306e-11 10.446253966384532 -0.17386852718775858 EAAWAISNLTISGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAAWAISNLTISGR 14 0 O00629;O00505 O00629;O00505 KPNA4;KPNA3 Importin subunit alpha-3;Importin subunit alpha-4 0 27748700.0 3436900.0 14640000.0 9671800.0 False True 5214028.571046416 12027377.617157927 7760164.490699475 1.0 2.3067341218546726 1.4883241211587892 22.313967057681733 -10.10978247164533 4.83068790378425 0.9999550546561055 1.8975291215135695 0.6159152963728146 0.33411448370618985 232797814.9601445 8.136913379777509 116382.77078035148 0.11437627469336334 7.766360187681977e-11 10.10978247164533 0.897574066857464 EAAWAISNLTISGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAAWAISNLTISGR 14 0 O00629;O00505 O00629;O00505 KPNA4;KPNA3 Importin subunit alpha-3;Importin subunit alpha-4 0 9382000.0 3975000.0 2092200.0 3314800.0 False True 3305388.6223578467 2080928.903330815 4007909.354096486 1.0 0.6295565033579674 1.2125380135294068 21.656388472097348 -6.73501600351375 1.704890642845938 0.7783244498160915 1.2125249172679309 0.5823801721375552 0.15567400740086873 0.32691364666788 1.8637166559209883 0.07229417304938542 0.17838686289746683 1.8407041712788436e-07 6.73501600351375 0.4342004674518394 EAAWAISNLTISGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAAWAISNLTISGR 14 0 O00629;O00505 O00629;O00505 KPNA4;KPNA3 Importin subunit alpha-3;Importin subunit alpha-4 0 20494400.0 3436900.0 9171600.0 7885900.0 False True 4449134.8014274165 8661192.39751564 6450747.116166979 1.0 1.9467138632744658 1.449887990379025 22.085093379774182 -10.2410109346605 4.916742539717766 0.9998704943268185 1.6983009268275358 0.7248210391527449 0.20282831327051287 0.0002879890493922312 4.44560764940087e-05 0.1964236579344218 0.06546255661927979 5.741020072929024e-11 10.2410109346605 0.6984304325007172 EACGVIVELIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EACGVIVELIK 11 0 Q9Y265;Q9Y265-2 Q9Y265 RUVBL1 RuvB-like 1 0 11137100.0 0.0 5027300.0 6109800.0 False True 0.0 4277246.436261911 5477616.5053400155 0.0 EACGVIVELIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EACGVIVELIK 11 0 Q9Y265;Q9Y265-2 Q9Y265 RUVBL1 RuvB-like 1 0 11929500.0 0.0 6121500.0 5808000.0 False True 0.0 5851031.888906536 4436270.019514745 0.0 EACGVIVELIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EACGVIVELIK 11 0 Q9Y265;Q9Y265-2 Q9Y265 RUVBL1 RuvB-like 1 0 6091280.0 2823300.0 527580.0 2740400.0 False True 2347699.0433969577 524737.8218235692 3313404.9698220063 1.0 0.22351153709391558 1.411341449041841 21.16281604743682 -6.730326577524117 1.7220496035027064 0.5328803234992705 1.4106746810585078 0.5607636670428962 0.32640913413457007 0.3356320307260588 1.9500403532359707 0.15019952381825685 0.3725707468304451 1.8606874246098274e-07 6.730326577524117 0.8777943575592373 EACWTISNITAGNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EACWTISNITAGNR 14 0 O60684;Q5TFJ7;P52294 O60684;P52294 KPNA6;KPNA1 Importin subunit alpha-7;Importin subunit alpha-5;Importin subunit alpha-5, N-terminally processed 0 15192900.0 4817400.0 3453300.0 6922200.0 False True 6315658.051767958 2938081.100857968 6205957.146431088 1.0 0.4652058545246134 0.9826303285520405 22.59050163090018 -10.83422450620211 10.455416744566232 1.0051025359676828 0.723918091538327 0.2751496902444015 0.21123765696586058 0.02520902419405484 0.00039970011352050697 0.20521642357529837 0.0681766606267211 1.4647904296499948e-11 10.83422450620211 -0.28118444442935586 EACWTISNITAGNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EACWTISNITAGNR 14 0 O60684;Q5TFJ7;P52294 O60684;P52294 KPNA6;KPNA1 Importin subunit alpha-7;Importin subunit alpha-5;Importin subunit alpha-5, N-terminally processed 0 12128400.0 4817400.0 3578400.0 3732600.0 False True 6598522.965339923 3420294.455813626 2851036.755310039 1.0 0.5183424341749532 0.4320719606926711 22.653711692423073 -13.999999999999998 0.24188840544194848 4.21753437466462 0.394605308027744 0.9995281333580182 0.005428103609483044 13.690889592311638 0.15565408201826847 21.3016155675645 0.041692435014937294 1.0000000000000041e-14 13.999999999999998 -3.822929066636876 EADAK(ub)AAIAQLNGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EADAKAAIAQLNGK 14 1 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 1 91047300.0 7975100.0 7405200.0 75667000.0 True False 12098809.757907484 6083684.20290832 60711384.283975795 1.0 0.5028332806813641 5.017963378116292 23.528361790982007 -6.87958988226452 1.0820497488101206 0.6934813505410771 5.335485586494597 0.9733546050567777 0.32997538461279574 0.12799557904029668 0.27446764323189304 0.23499333408383394 0.5677029438588632 1.3195021972096524e-07 6.87958988226452 4.64200423595352 up EADAK(ub)AAIAQLNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EADAKAAIAQLNGK 14 1 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 1 34238400.0 4006200.0 18985000.0 11247200.0 True False 5487400.403484209 18146179.925000496 8590843.003355054 1.0 3.3068809619721993 1.5655578911100276 22.387691419242625 -6.574607280454616 2.288244376966255 2.5760084274229835 1.5694983904539417 0.0 1.0035481375271273 0.7157404377289953 7.041391246446924 0.36952029130047787 1.123385414978835 2.663132162274885e-07 6.574607280454616 -1.0065100369690418 EADAK(ub)AAIAQLNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EADAKAAIAQLNGK 14 1 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 1 91174600.0 7975100.0 8319500.0 74880000.0 True False 10323924.162723312 7856512.511571744 61252608.33368209 1.0 0.7610006028462827 5.933074223350792 23.299488113074457 -6.896065063639409 0.9857891346860975 0.7611385286268026 6.434634053171507 0.9845054865141901 0.2967286567269566 0.11436071603902917 0.19419506281887272 0.2273177945247685 0.5806006796691344 1.270383768958072e-07 6.896065063639409 5.6734955245447045 up EADDIVNWLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EADDIVNWLK 10 0 P07237;I3L312;I3L3P5 P07237 P4HB Protein disulfide-isomerase 0 23210000.0 1111500.0 12169000.0 9929500.0 False True 1457187.2637813112 10353432.634390492 8902090.59048965 1.0 7.105080377606356 6.10909168076948 20.47475486001995 -10.023343378714447 6.264109118365455 0.9999957258124866 6.6070860291880535 0.9768826504133711 0.40661068280546975 2.4270889356435094e-05 3.7798716137641193e-06 0.3936994042532249 0.1312330335745631 9.47668884352593e-11 10.023343378714447 5.607090303375567 EADDIVNWLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EADDIVNWLK 10 0 P07237;I3L312;I3L3P5 P07237 P4HB Protein disulfide-isomerase 0 19673600.0 10213000.0 0.0 9460600.0 False True 9888793.905313559 0.0 6982585.048083636 1.0 0.0 0.7061108882380159 23.237363141579486 -10.553866899587684 8.592923215940706 1.0000949029221742 0.35305544636916036 0.528134919997434 0.28826856300108983 0.000524181958715303 2.7214575472887216e-05 0.2791547939809289 0.09303827864486373 2.793399817342601e-11 10.553866899587684 -0.6470394565530138 EADDIVNWLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EADDIVNWLK 10 0 P07237;I3L312;I3L3P5 P07237 P4HB Protein disulfide-isomerase 0 25281500.0 1111500.0 12589000.0 11581000.0 False True 1522451.5871580788 12032776.353744052 8845806.31818186 1.0 7.90355270094685 5.810238166386688 20.53796492154284 -9.504013723239051 8.379707647016339 0.9999999813044178 6.856895433666936 0.9125698145189781 0.8545920801379394 0.0 0.0 0.8274552235434808 0.27581840784782685 3.1331867174171525e-10 9.504013723239051 5.856895452362518 EADETK(ub)LAEEIPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EADETKLAEEIPLK 14 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 56369900.0 20484200.0 24754700.0 11131000.0 True False 26854984.569274977 21061395.253064815 9979270.896091474 1.0 0.7842639119279682 0.3715984595094069 24.67868655674066 -6.9609070244948015 0.42245644036594787 1.0177653442690404 0.12246735267148463 0.999802373223524 0.0036650391863976436 0.07937869410204028 0.019945815738622984 0.005347063571870805 0.0343283688504868 1.0941905899111223e-07 6.9609070244948015 -0.8952979915975557 down EADETK(ub)LAEEIPLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EADETKLAEEIPLK 14 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 76779200.0 30712400.0 23428100.0 22638700.0 True False 29737451.67311781 32783062.50592754 16708945.3235578 1.0 1.1024166719558863 0.5618822186657785 24.825777686313483 -6.8576692260021295 1.1974539522407568 1.0552584360338322 0.5368479430406445 0.9507454631117921 0.05202774509590262 0.14922081935046697 0.40791145762385145 0.033918488227060214 0.07897974870665789 1.3878124333537993e-07 6.8576692260021295 -0.5184104929931876 EADETK(ub)LAEEIPLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EADETKLAEEIPLK 14 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 156757000.0 40655000.0 67913000.0 48189000.0 True False 61676607.27862089 55793394.54330915 38664423.02801099 1.0 0.9046119267109711 0.6268895896518181 25.87822007153761 -6.952121796979721 0.5350422302078893 1.0042275301565902 0.5145571870415617 0.9993574505017084 0.0040118717294218495 0.0826447541685749 0.032521514875625296 0.0044432783583785215 0.022982024542638792 1.1165500697342184e-07 6.952121796979721 -0.48967034311502844 EADETK(ub)LAEEIPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EADETKLAEEIPLK 14 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 60609000.0 20484200.0 19240000.0 20884800.0 True False 28057762.30469052 18389913.181828238 15952240.375957565 1.0 0.6554305001990101 0.5685499863718915 24.741896618263553 -13.999999999999998 0.19347210768658696 2.869797857588316 0.5083525856493161 0.9994878709896842 0.004216394603458935 12.409322559976184 0.13948721498326105 8.757883523770943 0.05813978329306435 1.0000000000000041e-14 13.999999999999998 -2.361445271939 EADETK(ub)LAEEIPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EADETKLAEEIPLK 14 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 118624000.0 40655000.0 62625000.0 15344000.0 True False 52628698.9298588 59139863.69820065 12551549.442735272 1.0 1.1237189005378918 0.2384924898003544 25.649346393630058 -6.87152811330635 1.125919225869299 1.0706683519886289 0.18510722919151554 0.9661877099720627 0.07197318894323353 0.13540123898899814 0.3198663702529488 0.04956071427203942 0.11766394331545844 1.3442247477776906e-07 6.87152811330635 -0.8855611227971133 down EADGILK(ub)PLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EADGILKPLPK 11 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 16079000.0 3652400.0 5432200.0 6994400.0 True False 5540957.826206741 4462781.468027681 5611953.7742455695 1.0 0.8054169708566139 1.0128129378106874 22.401703955648493 -11.125493355538461 11.052666683979584 3.215790314023061 0.9091149543336499 0.20385267725981704 0.08466904895810032 0.03872541280425478 0.00043969400684003637 0.0006867291781612481 0.027326818046161917 7.490428183573183e-12 11.125493355538461 -2.306675359689411 EADGILK(ub)PLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EADGILKPLPK 11 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 13984100.0 3652400.0 4635000.0 5696700.0 True False 4728103.799567491 4377058.175507545 4659959.053078088 1.0 0.9257534015873217 0.9855872989726586 22.172830277740943 -10.481706690445732 5.619802884380692 1.0000541983215292 0.9556703502800346 0.42258877079701773 0.02442708631935424 1.6607830677747737e-05 1.5316730093740056e-06 0.023680331763566653 0.007883808209269132 3.298323959456232e-11 10.481706690445732 -0.044383848041494645 EADGSETPEPFAAEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EADGSETPEPFAAEAK 16 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 10167450.0 3088300.0 985650.0 6093500.0 False True 2990263.606949951 1379225.1850968467 4497429.548918427 1.0 0.46123866199998576 1.5040244406765781 21.511841240261287 -6.766309395810471 1.5888687226608798 0.6895226471494048 1.5090497887506127 0.716139845212991 0.22685690222576704 0.27243929278394585 1.3567987769152 0.11258766294409073 0.2688917035702086 1.7127367017103358e-07 6.766309395810471 0.8195271416012079 EADGSETPEPFAAEAK(ub)FFTESR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EADGSETPEPFAAEAKFFTESR 22 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 31826300.0 7441200.0 14602000.0 9783100.0 True False 9755485.260683307 12423438.518150212 8770838.658121685 1.0 1.2734823728573839 0.8990673886280205 23.217782206973357 -6.71091164399524 1.7921463559759259 1.1679794191007187 0.8999318124047649 0.46929040363025976 0.11522830720297883 0.37327411128015237 2.3376098943298365 0.05115757948525007 0.12981153302047352 1.9457558999847812e-07 6.71091164399524 -0.26804760669595373 EADGSETPEPFAAEAK(ub)FFTESR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EADGSETPEPFAAEAKFFTESR 22 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 74124000.0 26426000.0 18030000.0 29668000.0 True False 25587121.09486105 25229473.025207918 21897060.779077977 1.0 0.9860223403669683 0.8557844666423144 24.608914497567213 -6.927375198295632 0.7680287648200038 1.0021852428419253 0.8307505985778786 0.9959967906070487 0.004108840200259154 0.09402385658995704 0.08452552609904185 0.0036864828826306505 0.011958875581519627 1.182019936728358e-07 6.927375198295632 -0.17143464426404675 EADGSETPEPFAAEAK(ub)FFTESR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EADGSETPEPFAAEAKFFTESR 22 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 133119000.0 39399000.0 41955000.0 51765000.0 True False 59771163.45272136 34467802.45408881 41533625.06059454 1.0 0.5766627327131191 0.694877306402901 25.832946289476897 -10.339334726497222 8.50409264993182 1.000000877035139 0.6357700195580132 0.9267801784489237 0.04826089761676784 8.025264559586076e-07 6.235124916933249e-08 0.04672852562569176 0.015576137728563587 4.577889161991853e-11 10.339334726497222 -0.3642308574771258 EADGSETPEPFAAEAK(ub)FFTESR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EADGSETPEPFAAEAKFFTESR 22 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 36004200.0 7441200.0 11309000.0 17254000.0 True False 10192412.730868824 10809330.986138025 13178960.557284325 1.0 1.0605272050454548 1.2930167670085042 23.28099226849625 -6.945807336648141 0.6031265952204499 0.9973982980813467 1.3681108398064776 0.9988297694289205 0.004320675217704521 0.08521440794721591 0.04327683211645694 0.00442093243135515 0.019557955346086696 1.1329028343905689e-07 6.945807336648141 0.3707125417251309 EADGSETPEPFAAEAK(ub)FFTESR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EADGSETPEPFAAEAKFFTESR 22 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 74199000.0 26426000.0 25110000.0 22663000.0 True False 21974389.87029645 24974727.446055215 27401728.518127333 1.0 1.1365379240774474 1.2469847253946835 24.38931977300149 -6.973535925343911 0.1515252483232312 0.874317497878411 1.5121138265281928 0.9999984751590909 0.00012460840253375184 0.07517108283299423 0.004638318448044399 0.005551798138593875 0.013693253859530635 1.0628306610526244e-07 6.973535925343911 0.6377963286497819 EADGSETPEPFAAEAK(ub)FFTESR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EADGSETPEPFAAEAKFFTESR 22 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 121592000.0 39399000.0 33145000.0 49048000.0 True False 51002782.17039745 31300451.613203388 40121767.27497919 1.0 0.6137008665258754 0.7866584050441523 25.604072611569347 -10.013633997809002 4.612080212966616 1.0000080357719043 0.7001796357669317 0.8002658635901263 0.07060961948656612 48730107.559295736 3.8350676447654246 4380.987743264498 0.02417155084650127 9.690942175222855e-11 10.013633997809002 -0.2998284000049727 EADK(ub)LEQANDDAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EADKLEQANDDAR 13 1 Q8IUR0;M0QZQ8 Q8IUR0 TRAPPC5 Trafficking protein particle complex subunit 5 1 7203350.0 2768600.0 3614000.0 820750.0 True False 2302213.5697760824 3594530.6646771696 992365.0302807663 1.0 1.5613367551416093 0.4310482065212071 21.134590243699996 -6.771718795109633 1.568367325490552 1.3212673510930386 0.424347134552212 0.7369147828820946 0.23668198915020583 0.26366016270145387 1.28023975736684 0.118945918351588 0.28263956428526404 1.6915358435229745e-07 6.771718795109633 -0.8969202165408265 down EADPSNFANFSAYPSEEDMIEWAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 EADPSNFANFSAYPSEEDMIEWAKR 25 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 72191000.0 11357000.0 40867000.0 19967000.0 True False 17229399.307915326 33573964.55467163 16020513.698153004 1.0 1.9486439402009492 0.929835881788 24.038369068003156 -6.662185523363622 1.9648868983308232 1.6095197792663922 0.9340436715028135 0.245035763031493 0.4036993176019321 0.47928614834226496 3.5593427103752506 0.16585056422478128 0.4477065593792106 2.1767796897096585e-07 6.662185523363622 -0.6754761077635787 EADPSNFANFSAYPSEEDMIEWAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EADPSNFANFSAYPSEEDMIEWAKR 25 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 17351900.0 5863200.0 4876700.0 6612000.0 True False 4875510.583800884 4850428.249150835 7994538.629566169 1.0 0.994855444528541 1.6397336221827523 22.217121881139317 -6.905102923402505 0.928457311602603 0.9768109830870336 1.7148963155831694 0.9889380236440796 0.031846554885110435 0.10774594555544749 0.15699976435008822 0.025457603781472844 0.06810283334468481 1.2442197093333692e-07 6.905102923402505 0.7380853324961357 EADPSNFANFSAYPSEEDMIEWAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EADPSNFANFSAYPSEEDMIEWAKR 25 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 64195000.0 11357000.0 38417000.0 14421000.0 True False 14701860.379938664 36279060.17874295 11796525.971955538 1.0 2.4676509802968423 0.8023832132192207 23.809495390095606 -6.674013310447691 1.9232611300945 1.9335405044204383 0.8089966209623304 0.2969369047597933 0.6228545236262085 0.4519419630444599 3.2266285437632107 0.2603761550657542 0.6920106526105569 2.1182962117825725e-07 6.674013310447691 -1.124543883458108 EAEAAIYHLQLFEELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAEAAIYHLQLFEELR 16 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 11368400.0 3475900.0 5783100.0 2109400.0 False True 4556938.560663479 4920284.022347239 1891139.5227935833 1.0 1.0797345535487881 0.4150021988706027 22.119633488750008 -6.876936091140849 1.0966824213300412 1.0476790816455275 0.3705644494067224 0.9711316672768314 0.05035313979609027 0.13038169216119622 0.2889461159904991 0.03545919945596352 0.08512465562639675 1.327589805612452e-07 6.876936091140849 -0.6771146322388051 down EAEAAIYHLQLFEELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAEAAIYHLQLFEELR 16 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 50538200.0 22129000.0 7613200.0 20796000.0 False True 21426527.007802166 10653190.462313518 15348903.733372867 1.0 0.4971963239042104 0.7163505185783856 24.352894688996486 -10.298773073037287 5.719420565741221 1.000038373477465 0.6067734212412954 0.8110585239530046 0.08946932532372807 4.3782500075816465e-05 5.367920902337846e-06 0.08663673239793178 0.028876100581266044 5.0260514147802456e-11 10.298773073037287 -0.39326495223616953 EAEAAIYHLQLFEELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAEAAIYHLQLFEELR 16 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 11220100.0 3475900.0 1871300.0 5872900.0 False True 4761034.162665554 1788619.7784384196 4485841.976172196 1.0 0.3756788372711502 0.9421990733334106 22.1828435502729 -10.584138621660957 9.326609543878403 1.0000451081917454 0.6589389553022852 0.3258049493446964 0.23128091788560193 0.00021695937267071356 9.673827435895282e-06 0.22396619317404898 0.07464559527220849 2.6053218293610663e-11 10.584138621660957 -0.3411061528894602 EAEAAIYHLQLFEELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAEAAIYHLQLFEELR 16 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 34546000.0 22129000.0 4947600.0 7469400.0 False True 18401243.980919927 4920946.29677829 9031217.005396472 1.0 0.2674246535658552 0.4907938297411226 24.133299964430762 -10.241681855488538 5.032767640075589 1.0000947489848937 0.3791092416539674 0.9115202884123801 0.09119008431719913 9.69612895966877e-05 1.460971094798496e-05 0.08830778546334844 0.029431473158123774 5.732157892023744e-11 10.241681855488538 -0.6209855073309263 EAEAAIYHLQLFEELRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAEAAIYHLQLFEELRR 17 1 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 42650500.0 16057200.0 4990200.0 21603100.0 False True 15547472.975266907 6982812.883549216 15944600.030891854 1.0 0.44912847860598004 1.0255428683655987 23.890176773678956 -10.97360933059685 12.986231032243605 1.1193124484821075 0.7373356734879603 0.21683311578529374 0.23532018921813513 0.086574304613976 0.00017593649081676548 0.02426632686239717 0.07594926448901795 1.0626510346382699e-11 10.97360933059685 -0.3819767749941473 EAEAAIYHLQLFEELRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAEAAIYHLQLFEELRR 17 1 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 179385300.0 6540700.0 147844000.0 25000600.0 False True 9922720.089220893 121460083.08955579 20059220.45184774 1.0 12.24060358424285 2.0215445232238474 23.242304226358417 -6.62346622170719 2.1041962381880714 8.4405000393788 2.0615005482270026 0.09444253741406117 4.829652090250878 0.5762326835133087 4.85294582819904 1.882904919748605 5.352890302337047 2.3797633855518586e-07 6.62346622170719 -6.378999491151799 EAEAAIYHLQLFEELRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAEAAIYHLQLFEELRR 17 1 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 18705300.0 4259000.0 5182800.0 9263500.0 False True 5833667.395147336 4953806.758772319 7075652.0877711335 1.0 0.8491753854347408 1.2128994693212931 22.47597170306619 -6.79411131603132 1.480085801427032 0.9161523845932252 1.2172059565917877 0.8143050620368844 0.06429756670144823 0.22927788777309077 0.9921342025951537 0.034187765361353345 0.07980133412086987 1.606529423234477e-07 6.79411131603132 0.3010535719985624 EAEAAIYHLQLFEELRR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAEAAIYHLQLFEELRR 17 1 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 23660700.0 16057200.0 4762400.0 2841100.0 False True 13352273.254572185 4736744.005937617 3435160.8742378126 1.0 0.35475187749888404 0.25727161276163363 23.670582049113232 -13.999999999999998 0.26610602325864924 5.8777687659551825 0.22367332408363208 0.9995750259194327 0.0067938606972234505 14.695815703255962 0.16326950313858243 38.68880815185756 0.04128924568338275 1.0000000000000041e-14 13.999999999999998 -5.654095441871551 EAEAAIYHLQLFEELRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAEAAIYHLQLFEELRR 17 1 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 52965000.0 6540700.0 27139000.0 19285300.0 False True 8467065.086472197 25628690.792901687 15775573.283888362 1.0 3.0268682868457653 1.8631690110771615 23.013430548450867 -10.463232868840826 6.016504655401752 0.9991480552390751 2.4450186489614625 0.6727652388078019 0.4750782399465689 0.0054314743744851264 0.0004845718809980074 0.4601991192162509 0.1533308426215492 3.441653397130642e-11 10.463232868840826 1.4458705937223875 EAEFTK(ub)SIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAEFTKSIAK 10 1 A0A087WUC6;E9PI68;Q15005;E9PL01;E9PRB9 A0A087WUC6 SPCS2 Signal peptidase complex subunit 2 1 9043000.0 1124400.0 1780000.0 6138600.0 True False 1474099.2887050873 1514430.9383856566 5503436.557609121 1.0 1.0273601988615015 3.733423250236813 20.49140227048594 -6.90911022446942 0.9017583793193731 0.913838670847823 4.076578225007779 0.990581773119054 0.12442930902170342 0.10500975056962511 0.14197515053654747 0.10142584483915075 0.2782899840653227 1.2327919094295393e-07 6.90911022446942 3.1627395541599563 up EAEFTK(ub)SIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAEFTKSIAK 10 1 A0A087WUC6;E9PI68;Q15005;E9PL01;E9PRB9 A0A087WUC6 SPCS2 Signal peptidase complex subunit 2 1 25655400.0 1617400.0 1490000.0 22548000.0 True False 1566056.522319998 2084964.7702473542 16642002.374499477 1.0 1.3313470749820906 10.626693313626747 20.578704852833834 -6.9144553224213565 0.8648503850733074 0.7511466712998394 11.949851668392172 0.992496948918244 0.3865007241339944 0.10154482210343707 0.12333389705384179 0.3235768163384086 0.9233453068471154 1.217712257243267e-07 6.9144553224213565 11.198704997092333 up EAEFTK(ub)SIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAEFTKSIAK 10 1 A0A087WUC6;E9PI68;Q15005;E9PL01;E9PRB9 A0A087WUC6 SPCS2 Signal peptidase complex subunit 2 1 13259800.0 1124400.0 1684400.0 10451000.0 True False 1540121.0657674691 1609977.63843407 7982689.045101332 1.0 1.0453578450547263 5.183156845610328 20.55461233200883 -6.909295409439682 0.9005171439489229 0.8690131887570133 5.709920950482055 0.9906530116340664 0.1896235058551445 0.10488584935503042 0.14130726942477984 0.15470849237141263 0.4250104557904342 1.2322663538983336e-07 6.909295409439682 4.840907761725042 up EAEFTK(ub)SIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAEFTKSIAK 10 1 A0A087WUC6;E9PI68;Q15005;E9PL01;E9PRB9 A0A087WUC6 SPCS2 Signal peptidase complex subunit 2 1 20426100.0 1617400.0 3114700.0 15694000.0 True False 1344939.7629689502 3097920.492880455 18975542.83914269 1.0 2.3033897711833617 14.108842166473123 20.35911012826811 -6.927863486753685 0.7641344035993671 0.805523727095318 16.40557957847006 0.9961012392112993 0.36817242457810717 0.09376266631924943 0.08322953052218915 0.33125351785606166 1.0810127828870237 1.1806917081272228e-07 6.927863486753685 15.600055851374742 EAELQK(ub)VR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAELQKVR 8 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 2536740.0 1048300.0 1071500.0 416940.0 True False 1374331.4517516415 911636.3766742873 373799.04837089 1.0 0.6633307965937689 0.27198609760001335 20.390298554652837 -7.312608763851266 0.33778724152453526 1.0560370686476168 1.4927676943406413e-15 0.9997496622861961 0.004706897497770454 0.10505954231816804 0.0255496598785092 0.012790159863656975 0.05103896714087421 4.8684558525163213e-08 7.312608763851266 -1.0560370686476153 down EAELSK(ub)GESVCLDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAELSKGESVCLDR 14 1 P62072 P62072 TIMM10 Mitochondrial import inner membrane translocase subunit Tim10 1 22890500.0 7598500.0 0.0 15292000.0 True False 11527480.024759578 0.0 12269529.497278303 1.0 0.0 1.0643722193337048 23.458573830008632 -10.553382199287167 5.0493475652301205 1.0025998279482264 0.5321861096668458 0.20481662001997702 0.4345281389602374 0.012776367216251385 0.0011300760792778048 0.4226797319390666 0.1402433538042884 2.7965191698149427e-11 10.553382199287167 -0.4704137182813807 EAELSK(ub)GESVCLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAELSKGESVCLDR 14 1 P62072 P62072 TIMM10 Mitochondrial import inner membrane translocase subunit Tim10 1 13215900.0 5462700.0 3108100.0 4645100.0 True False 4542477.088642573 3091356.0483904537 5616368.9334842395 1.0 0.6805441146020711 1.2364110646868618 22.11504780713302 -6.750870834817726 1.6468671278561426 0.8123544998213433 1.2375743359789884 0.6526474632623946 0.13424249661680296 0.29850985387843626 1.5932132475211398 0.06438886398677024 0.15616104784809054 1.774717227842555e-07 6.750870834817726 0.425219836157645 EAENPEGEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAENPEGEEK 10 0 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 0 2628950.0 888780.0 483770.0 1256400.0 False True 860566.165393575 676941.883827223 927311.1488079274 1.0 0.7866238658332884 1.077559386016329 19.71492659385565 -6.710141193606594 1.7948278884170008 0.8688401242428022 1.076875395224441 0.4657417008525 0.08991337477368169 0.37477798910761234 2.3535666645409923 0.03986571057612098 0.10125551755822688 1.94921078824232e-07 6.710141193606594 0.20803527098163876 EAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK 32 0 Q3ZCM7;A0A075B736;Q5SQY0 Q3ZCM7 TUBB8 Tubulin beta-8 chain 0 24464300.0 10038000.0 11507000.0 2919300.0 False True 13159915.208130281 9790200.453934692 2617238.8399029593 1.0 0.7439409980306136 0.19887961271103116 23.64964685775247 -7.127622919733802 0.507247446587563 1.0096890195362571 1.2381859794153133e-23 0.999357221416057 0.008469815262015097 0.07904940895708264 0.03267154335339759 0.009649230727363662 0.043731210481405394 7.453788752411146e-08 7.127622919733802 -1.0096890195362571 down EAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK 32 0 Q3ZCM7;A0A075B736;Q5SQY0 Q3ZCM7 TUBB8 Tubulin beta-8 chain 0 92698000.0 65907000.0 13729000.0 13062000.0 False True 63814818.360667884 19211061.29578919 9640670.348399518 1.0 0.30104389214449107 0.15107259718130803 25.927388133548614 -13.999999999999913 0.2163133822724814 5.150919393578021 0.0679628624423211 0.9994944779585965 0.008317689513517768 12.901958092590986 0.14736822550949583 22.83282216183077 0.08506346954916594 1.0000000000002004e-14 13.999999999999913 -5.0829565311357 EAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK 32 0 Q3ZCM7;A0A075B736;Q5SQY0 Q3ZCM7 TUBB8 Tubulin beta-8 chain 0 863630000.0 140370000.0 534400000.0 188860000.0 False True 212951552.4215965 439032144.713742 151531738.21972156 1.0 2.0616527079575193 0.7115784623148582 27.665950006304712 -6.697016792961991 1.8416427549711676 1.6611594697374856 0.7158265952993107 0.40341337597017646 0.44838520220113876 0.40173765437390613 2.646893598148679 0.19439779173454064 0.5017640838169853 2.0090151280689445e-07 6.697016792961991 -0.9453328744381749 EAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK 32 0 Q3ZCM7;A0A075B736;Q5SQY0 Q3ZCM7 TUBB8 Tubulin beta-8 chain 0 22310500.0 10038000.0 5588200.0 6684300.0 False True 13749319.866750158 5341294.846293793 5105606.007479751 1.0 0.38847702272245427 0.3713351683545152 23.71285691927536 EAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK 32 0 Q3ZCM7;A0A075B736;Q5SQY0 Q3ZCM7 TUBB8 Tubulin beta-8 chain 0 118764100.0 65907000.0 6891100.0 45966000.0 False True 54804590.675154395 6853976.276523748 55577278.07722904 1.0 0.1250620831592305 1.0140989539846146 25.70779340898289 -10.012921506908581 13.879583736788163 1.0000002109203983 0.5695792498672962 0.23810902637915665 0.362947782675304 0.0 0.0 0.3514226794630849 0.11714089315436162 9.706853901792204e-11 10.012921506908581 -0.430420961053102 EAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK 32 0 Q3ZCM7;A0A075B736;Q5SQY0 Q3ZCM7 TUBB8 Tubulin beta-8 chain 0 376080000.0 140370000.0 127440000.0 108270000.0 False True 181711732.10636505 120347851.97123665 88565970.94401392 1.0 0.6623009454380797 0.48739819888003594 27.43707632839716 -13.999999999989289 0.08376626382420481 2.7827439392814237 3.5431798878821516e-17 0.9998716377669364 0.0024104742790437106 12.188998073381104 0.0822868229597206 3.9610580884228614 0.4395459125163996 1.000000000024664e-14 13.999999999989289 -2.7827439392814237 EAESLIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAESLIAK 8 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 7561820.0 2320800.0 675120.0 4565900.0 False True 2247127.474341694 944698.9367042907 3369953.8159361044 1.0 0.4204029132708835 1.499671849690391 21.099650536914627 -6.760830300607727 1.6093004096090104 0.6636859321949233 1.5037835715717625 0.6943656797672826 0.2438101070392704 0.2815246880243606 1.4371753790487856 0.11952339952251237 0.2870036445198181 1.734481609348105e-07 6.760830300607727 0.8400976393768391 EAESLIAK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAESLIAKK 9 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 17073600.0 5512200.0 6828000.0 4733400.0 True False 7226547.580220738 5809289.015335539 4243633.173978925 1.0 0.8038816531473099 0.5872282894246579 22.784875146172862 -6.969842930905367 0.26191492599599914 1.059421013380824 0.3252450697217952 0.9999811290104795 0.0007323137876473277 0.07635374308146455 0.009212564791361753 0.004467368399143511 0.020383443665649665 1.0719069063064884e-07 6.969842930905367 -0.7341759436590287 EAESLIAK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAESLIAKK 9 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 21635700.0 6372000.0 8535700.0 6728000.0 True False 6169724.347856461 11944049.523087468 4965734.964326438 1.0 1.9359129921642566 0.8048552389624467 22.556774603129302 -6.686981165725858 1.877346013054333 1.588409982319467 0.8089192047382702 0.3562922106113755 0.3960707450946111 0.42316149369960715 2.889198607213095 0.16893463723205548 0.4415658512412151 2.055979756791698e-07 6.686981165725858 -0.7794907775811969 EAESLIAK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAESLIAKK 9 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 16141000.0 5512200.0 4918500.0 5710300.0 True False 7550209.30160393 4701184.406695538 4361644.747320083 1.0 0.6226561700344971 0.577685276405982 22.848085207695753 -13.999999999999998 0.3001071858956408 4.444132446489521 0.5666324445526342 0.9996500695944627 0.0035424944653162753 16.595452903721355 0.1739828058457491 35.49389792580742 0.016244712290265112 1.0000000000000041e-14 13.999999999999998 -3.8775000019368866 EAESLIAK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAESLIAKK 9 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 23500900.0 6372000.0 11620000.0 5508900.0 True False 5298600.327462695 11557400.7536106 6660785.5197242955 1.0 2.181217687567127 1.257083967100025 22.33717987856358 -10.438364598683874 5.157517545562378 0.9990876205608171 1.7191508273335954 0.4467306113877212 0.3772760115407819 0.0039625639193931125 0.0004315084777706012 0.3657159663815962 0.12176530913507265 3.644478573785478e-11 10.438364598683874 0.7200632067727782 EAESSPFVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAESSPFVER 10 0 P14625 P14625 HSP90B1 Endoplasmin 0 19420500.0 4792500.0 1800000.0 12828000.0 False True 4640364.710781864 2518749.386875996 9467961.968249036 1.0 0.5427912553993212 2.040348670493566 22.145806768159503 -6.8247715297174825 1.3510114477440773 0.7546728632040753 2.076532802851044 0.8950113031868371 0.2030420348329375 0.18736470149119117 0.6706219133398336 0.11805531081028216 0.2718277257658964 1.4970229912570165e-07 6.8247715297174825 1.3218599396469688 up EAFEQLQAK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAFEQLQAKK 10 1 O95229;O95229-2;A6NH27 O95229 ZWINT ZW10 interactor 1 5553700.0 706100.0 1225600.0 3622000.0 True False 683685.2419995994 1714988.4714195651 2673289.5423291265 1.0 2.5084474054225234 3.9101173728870586 19.382972758143822 -6.972007963367663 0.20462091307434788 0.21385627074443508 6.243604250564998 0.9999940984046287 0.002886796383074744 0.07565640101192556 0.006644958606916351 0.043823247193822135 0.14711027952923508 1.066576563949326e-07 6.972007963367663 6.029747979820563 EAFEQLQAK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAFEQLQAKK 10 1 O95229;O95229-2;A6NH27 O95229 ZWINT ZW10 interactor 1 3742400.0 706100.0 1282700.0 1753600.0 True False 587153.4355338055 1275789.8405039855 2120269.6522696977 1.0 2.1728389264113086 3.611099797690995 19.1633780335781 -6.968388502950455 0.29414016251365427 0.7325328506551666 5.096100759891156 0.999966943273231 0.006139375840112626 0.07682913272096042 0.010891874327165965 0.02458273496202313 0.12981578467986446 1.075502680308364e-07 6.968388502950455 4.363567909235989 EAFLQEVWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAFLQEVWK 9 0 P26640;A0A140T936;P26640-2 P26640 VARS Valine--tRNA ligase 0 8912400.0 1119000.0 4345500.0 3447900.0 False True 1467019.836411414 3697168.3386263316 3091144.382592202 1.0 2.5201897389951107 2.107091060304733 20.484456947969353 -10.290908204546849 5.409072150327291 0.9998081644855251 2.3136403996499255 0.9309531738938537 0.16864682936844522 0.0003902218997335758 5.115506472265479e-05 0.16331448890667863 0.05443053012785782 5.1178999954474974e-11 10.290908204546849 1.3138322351644005 EAFLQEVWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAFLQEVWK 9 0 P26640;A0A140T936;P26640-2 P26640 VARS Valine--tRNA ligase 0 6275520.0 2170400.0 875520.0 3229600.0 False True 2101501.840016896 1225119.7017764833 2383670.874076791 1.0 0.5829734137975504 1.1342701817751568 21.002989288998496 -6.704411374817521 1.8153292989162808 0.7421680808849057 1.1327626782245683 0.43846066189208455 0.17589430721353425 0.38640930193340717 2.478614739328072 0.07721549399031408 0.19748960853484862 1.9750978906360103e-07 6.704411374817521 0.3905945973396626 EAFLQEVWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAFLQEVWK 9 0 P26640;A0A140T936;P26640-2 P26640 VARS Valine--tRNA ligase 0 8739000.0 1119000.0 4019900.0 3600100.0 False True 1532724.5398379571 3842287.5259683677 2749830.526386884 1.0 2.506835002703475 1.7940800547746185 20.547667009492244 -10.695190755484232 7.0539090830306375 0.9918571984400345 2.1504575287390297 0.7764742254625129 0.2909809890116153 0.03687988440461781 0.001593629084044792 0.2788492976317634 0.09391371037541245 2.0174800298081434e-11 10.695190755484232 1.1586003302989951 EAFQLFDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAFQLFDR 8 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;G3V1Y7 P60660-2 MYL6 Myosin light polypeptide 6 0 19271200.0 1184600.0 9220700.0 8865900.0 False True 1553022.0716827202 7845007.502007082 7948541.715718036 1.0 5.051446238305494 5.118112524380084 20.566646902900597 -10.267987941231297 0.8374692991638705 4.345141886982686e-10 5.103074683994171 0.9999630872286743 0.011700219179949423 1.6094297925241994 0.45197667769675476 3.865705173213553 0.009397408077932856 5.3952560295905036e-11 10.267987941231297 5.103074683559657 EAFQLFDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAFQLFDR 8 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;G3V1Y7 P60660-2 MYL6 Myosin light polypeptide 6 0 15599600.0 5285600.0 1857200.0 8456800.0 False True 5117811.521191168 2598789.645170055 6241710.381438148 1.0 0.5077931522896701 1.219605363658526 22.287095586093905 -6.720695452105474 1.7569403845984193 0.7007684655753432 1.2185298065130448 0.5157478060759564 0.20710482326851573 0.3539641993220579 2.135757029659616 0.09358594383967263 0.2347324558033021 1.9024118737391873e-07 6.720695452105474 0.5177613409377015 EAFQLFDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAFQLFDR 8 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;G3V1Y7 P60660-2 MYL6 Myosin light polypeptide 6 0 18482000.0 1184600.0 8801100.0 8496300.0 False True 1622578.6326113022 8412238.300654296 6489648.926791165 1.0 5.184487291759804 3.9995897865036145 20.62985696442349 -9.946883256532121 5.990346531987996 0.9999982420742471 4.592038539132605 0.9245480697337015 0.4837323808989252 1.1404718279792576e-05 2.003954349208335e-06 0.4683720868602449 0.15612395460309964 1.1300996579341036e-10 9.946883256532121 3.592040297058358 EAFSDGITSVK(ub)NSWFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAFSDGITSVKNSWFK 16 1 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 14143000.0 3818100.0 6929800.0 3395100.0 True False 5005566.074532999 5895900.852148835 3043807.6200988395 1.0 1.1778689491575438 0.6080845951839354 22.25510180057154 -6.822838154082439 1.3596866042731994 1.0956024999027087 0.5948852699552549 0.8907624863716506 0.07866880961991776 0.18981633040918663 0.688776734786797 0.04545876449054008 0.10469714823007144 1.503702237373354e-07 6.822838154082439 -0.5007172299474538 EAFSDGITSVK(ub)NSWFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAFSDGITSVKNSWFK 16 1 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 31489200.0 12219000.0 6414200.0 12856000.0 True False 11831114.533342456 8975423.50961112 9488627.92826704 1.0 0.7586287398635669 0.8020062608240484 23.496082651328564 -10.369775319870747 5.807612328235973 1.0000480501601676 0.7803175003438115 0.9715892598196728 0.017708798776678466 1.1019913623414565e-05 1.195849864691057e-06 0.017150213959198586 0.005715490228617603 4.268002647283522e-11 10.369775319870747 -0.2197305498163561 EAFSDGITSVK(ub)NSWFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAFSDGITSVKNSWFK 16 1 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 103362000.0 15070000.0 12131000.0 76161000.0 True False 22862291.764575474 9966128.270064391 61107744.96744789 1.0 0.43591991444648814 2.6728617409271607 24.44646669382107 -6.839874228841131 1.2828344806810141 0.6998973121470822 2.7463165435416084 0.9242536763854933 0.2614282730794144 0.16895184779897035 0.5401235309239922 0.15979287961641297 0.3681491213827031 1.4458584289810962e-07 6.839874228841131 2.046419231394526 up EAFSDGITSVK(ub)NSWFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAFSDGITSVKNSWFK 16 1 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 20146600.0 3818100.0 8018200.0 8310300.0 True False 5229754.750272842 7663929.411358388 6347578.296000915 1.0 1.4654471915644902 1.2137430145590966 22.318311862094433 -10.05627346899435 4.308536116228127 0.999971311961503 1.3395951029624347 0.7082048016141855 0.10275780015703578 14788210.40907783 11505400.566824561 3549.8593861600366 0.03517672783474477 8.784691832151735e-11 10.05627346899435 0.33962379100093165 EAFSDGITSVK(ub)NSWFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAFSDGITSVKNSWFK 16 1 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 35579000.0 12219000.0 10177000.0 13183000.0 True False 10160639.893481905 10122174.481023673 15939504.348694919 1.0 0.9962142726381921 1.568750050764045 23.27648792676284 -6.9054115839964 0.9264287883972138 0.9795993073991186 1.6359116887661367 0.9890713179418288 0.028122195727500042 0.10753095973011671 0.1558101772464786 0.022513883627414813 0.0603387416413073 1.2433357350480823e-07 6.9054115839964 0.6563123813670181 EAFSDGITSVK(ub)NSWFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAFSDGITSVKNSWFK 16 1 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 72398000.0 15070000.0 10017000.0 47311000.0 True False 19508412.07411072 9459545.144349312 38700883.451854065 1.0 0.4848957008091352 1.9838048993856012 24.21759301591352 -6.81394989650859 1.3980323621009951 0.7205578128209223 2.0124214056221876 0.8698500258951337 0.22432942770979575 0.20146563723669655 0.7753133012489004 0.1261489248431741 0.2912986672087949 1.5347940380175308e-07 6.81394989650859 1.2918635928012652 EAFSLFDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAFSLFDK 8 0 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479;P27482 P0DP25;P27482 CALM2;CALM3;CALM1;CALML3 Calmodulin-like protein 3 0 11950100.0 3870000.0 2177600.0 5902500.0 False True 3747148.968330897 3047127.0360339857 4356458.178795601 1.0 0.8131854542711912 1.1626060814806918 21.837361902635763 -6.761501487206248 1.6071242737800586 0.8916887711015974 1.163964572314919 0.6969514782854251 0.07859160403737121 0.28040197269807765 1.4277786491634292 0.038580329209208085 0.09256632565688619 1.7318031003206296e-07 6.761501487206248 0.2722758012133216 EAFSLFDK(ub)DGDGTITTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAFSLFDKDGDGTITTK 17 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 26456700.0 7580200.0 10126000.0 8750500.0 True False 9937715.60676121 8615240.270838847 7845082.20072306 1.0 0.8669236081758462 0.7894251064485677 23.244482825381446 -13.999999983804535 0.05948392435743345 1.8516908297040224 0.43512572273774835 0.999955508301507 0.0005800074046392765 12.46950644246595 0.06216039116803703 1.589778806522901 0.33246885719694363 1.0000000372914358e-14 13.999999983804535 -1.4165651069662741 EAFSLFDK(ub)DGDGTITTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAFSLFDKDGDGTITTK 17 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 40298000.0 12617000.0 14644000.0 13037000.0 True False 12216480.241196616 20491425.56745113 9622218.598383432 1.0 1.677359203541263 0.7876424639836299 23.542325346257112 -6.703157191940253 1.8195640224707166 1.4192859768074384 0.7901158432290281 0.4327227166804414 0.285756645226281 0.38892297124058717 2.505496261526 0.12518572795522953 0.32070144804381395 1.9808099462016032e-07 6.703157191940253 -0.6291701335784103 EAFSLFDK(ub)DGDGTITTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAFSLFDKDGDGTITTK 17 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 79550000.0 26973000.0 31280000.0 21297000.0 True False 40920012.99043762 25697839.60824451 17087638.615193292 1.0 0.628001746095479 0.4175863438554238 25.28630326729177 -9.860750944511308 0.1264628553524719 1.7172225652174096 5.716542010662805e-13 0.9998566101604897 0.0028834692297228823 1.3914189809694355 0.05624481990211224 0.5554964302852115 0.22397138032151975 1.3779994857171247e-10 9.860750944511308 -1.7172225652168378 EAFSLFDK(ub)DGDGTITTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAFSLFDKDGDGTITTK 17 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 29186400.0 7580200.0 11659000.0 9947200.0 True False 10382804.78720257 11143866.828842808 7597876.229014638 1.0 1.0733002360381745 0.7317749283295276 23.307692886904338 -6.850557769427575 1.2324065745129027 1.0391347011698737 0.717975250496477 0.9411121531201216 0.0356241469879675 0.15684425112555772 0.45813485663707093 0.022615874500458464 0.05235312341338075 1.4107245707730245e-07 6.850557769427575 -0.3211594506733967 EAFSLFDK(ub)DGDGTITTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAFSLFDKDGDGTITTK 17 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 34421000.0 12617000.0 16088000.0 5716000.0 True False 10491594.527871422 16001330.750782045 6911189.172202089 1.0 1.5251571825687453 0.6587358245538545 23.322730621691388 -6.742675455913437 1.6774727630015354 1.311503929582374 0.657982530541648 0.6166622907068195 0.2206382046330119 0.3129908390705189 1.730409833641383 0.10402371593864848 0.2544625972280203 1.8085251145700835e-07 6.742675455913437 -0.653521399040726 EAFSLFDK(ub)DGDGTITTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAFSLFDKDGDGTITTK 17 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 85141000.0 26973000.0 40112000.0 18056000.0 True False 34917080.217318445 37879731.93871816 14769993.270205181 1.0 1.0848482090415532 0.42300195715904804 25.05742958938422 -6.874703870622121 1.1089816576559477 1.0496578222766617 0.3806243419096179 0.9691531715800552 0.05164404427817433 0.13242127468036632 0.3015575996142066 0.036029431324904465 0.08606534792307113 1.3344310212814906e-07 6.874703870622121 -0.6690334803670438 down EAFSLFDK(ub)DGDGTITTK(ub)ELGTVMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAFSLFDKDGDGTITTKELGTVMR 24 2 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 2 37322300.0 2312300.0 8124000.0 26886000.0 True False 3507928.1517735817 6674208.726898293 21571970.31544759 1.0 1.9026070199082794 6.149490349322282 21.742187768605834 -6.941169791476255 0.6485889843512797 0.9531257976042424 7.33525944669074 0.9983131479834921 0.09221294710171161 0.08723698201311517 0.05220954266905129 0.09057894057180818 0.3636780911776329 1.1450651800163995e-07 6.941169791476255 6.382133649086498 EAFSLFDK(ub)DGDGTITTK(ub)ELGTVMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAFSLFDKDGDGTITTKELGTVMR 24 2 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 2 74055600.0 2312300.0 14734300.0 57009000.0 True False 2993317.932247261 13914323.25250934 46633946.96173721 1.0 4.648461529130998 15.579349744090278 21.513314090698284 -6.951480513415678 0.5423473384722324 0.841507315708867 19.893126621286726 0.999312400404156 0.16243446608174014 0.08289664956780257 0.03354383250251833 0.17808905600737746 0.9055782269548891 1.1181999965541284e-07 6.951480513415678 19.05161930557786 EAFSLFDKDGDGTITTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAFSLFDKDGDGTITTK 17 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 0 77786000.0 3834800.0 40706000.0 33245200.0 False True 5027459.936256022 34632823.47074525 29805305.614476748 1.0 6.888731866560931 5.928501866227288 22.261398249088007 -10.076672553752424 6.196159839677775 0.9999897216785759 6.408616866394193 0.9769063644839412 0.39201225608862406 5.567131966003304e-05 8.292043206487905e-06 0.37956495045121996 0.12652141161165922 8.381609945824616e-11 10.076672553752424 5.408627144715617 EAFSLFDKDGDGTITTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAFSLFDKDGDGTITTK 17 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 0 73648600.0 24971500.0 10880000.0 37797100.0 False True 24178793.40120802 15224440.738450471 27896905.621305447 1.0 0.6296608968787428 1.1537757554068708 24.52723891551787 -6.716831556026749 1.7704256344588973 0.7739389892778143 1.1528344322808188 0.4976938382000642 0.1559029363400613 0.36149102850248716 2.2125435274927456 0.06996385495036066 0.1763126533252752 1.919413053303622e-07 6.716831556026749 0.3788954430030045 EAFSLFDKDGDGTITTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAFSLFDKDGDGTITTK 17 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 0 100641300.0 3834800.0 54597000.0 42209500.0 False True 5252629.191573366 52184724.011864714 32240485.43193998 1.0 9.934972012793725 6.1379709581750825 22.3246083106109 -9.60651368966478 8.63194266544572 0.9999999999942747 8.03647148548036 0.8207552296956702 1.550119189437585 0.0 0.0 1.500896462514609 0.5002988171106862 2.4744934600667336e-10 9.60651368966478 7.036471485486086 EAFSLFDKDGDGTITTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAFSLFDKDGDGTITTK 17 1 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 0 29535800.0 24971500.0 2412600.0 2151700.0 False True 20764908.675021123 2399602.8449363923 2601610.5216632653 1.0 0.11556048150709969 0.1252888015247011 24.307644190952146 -10.13381304030791 5.225107180838928 1.0000262031408138 0.12042464151517153 0.9999082614382045 0.003971570018816857 1.2123456344662548e-06 2.0097525190323527e-07 0.0038455702883117113 0.0012818187113978908 7.34830137543539e-11 10.13381304030791 -0.8796015616256423 EAFSLFDKDGDGTITTK(ub)ELGTVMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 EAFSLFDKDGDGTITTKELGTVMR 24 2 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 103391600.0 33338700.0 52207100.0 17845800.0 True False 43707358.55243002 44418004.18168196 15999287.805001292 1.0 1.0162591758639332 0.36605478653689477 25.381372855914154 -6.901167793688589 0.9538844649659222 1.0261737663821977 0.2961699492943722 0.9871375748904438 0.03433564432028834 0.11054988583596764 0.17262384006444498 0.026937225216704212 0.07050347459875089 1.2555447786389962e-07 6.901167793688589 -0.7300038170878256 down EAFSLFDKDGDGTITTK(ub)ELGTVMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 EAFSLFDKDGDGTITTKELGTVMR 24 2 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 474411000.0 184937000.0 143325500.0 146148500.0 True False 179066276.16439596 200556119.5826085 107867823.48898087 1.0 1.1200105563064442 0.6023904992023753 27.41591841696121 -6.845663288928005 1.255793800344371 1.0638797380255982 0.5833619012551254 0.9337550844851269 0.05693661928569012 0.16229719111244525 0.49470714016789435 0.03551333057440248 0.08198604450896117 1.4267133041500615e-07 6.845663288928005 -0.4805178367704728 EAFSLFDKDGDGTITTK(ub)ELGTVMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 EAFSLFDKDGDGTITTKELGTVMR 24 2 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 841766000.0 247164000.0 311482000.0 283120000.0 True False 374965858.10879505 255895603.48002586 227161207.9040955 1.0 0.6824504096737752 0.6058183778379777 28.48218399849532 -13.999999999999996 0.1996854994308316 2.763107587815752 0.555895540027217 0.9994869181213514 0.0038654164978399914 12.524707202369807 0.1416940693776129 8.623610602384407 0.048909977040508895 1.0000000000000082e-14 13.999999999999996 -2.207212047788535 EAFSLFDKDGDGTITTK(ub)ELGTVMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EAFSLFDKDGDGTITTKELGTVMR 24 2 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 123120800.0 33338700.0 38171100.0 51611000.0 True False 45664918.33449123 36484574.5870522 39421544.761910304 1.0 0.7989628782385227 0.863278556049333 25.444582917437046 -10.189296880689252 7.190816210037364 1.0000002500110732 0.8311207171439279 0.9018935593344213 0.0262567655162879 1.052366955404401e-07 1.1906346233967242e-08 0.025423041396467432 0.00847433463082135 6.467003847246904e-11 10.189296880689252 -0.1688795328671453 EAFSLFDKDGDGTITTK(ub)ELGTVMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 EAFSLFDKDGDGTITTKELGTVMR 24 2 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 444671900.0 184937000.0 159017700.0 100717200.0 True False 153783309.59823745 158161040.08755803 121776700.85628276 1.0 1.02846687654699 0.7918720254781048 27.196323692395485 -6.87684465454034 1.0973005305559786 1.0170023012194764 0.7760906354105358 0.9710473843638315 0.0179452679636712 0.13045917880298655 0.2895196184553051 0.01263202817989837 0.030315787095000088 1.3278693465309799e-07 6.87684465454034 -0.24091166580894063 EAFSLFDKDGDGTITTK(ub)ELGTVMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 EAFSLFDKDGDGTITTKELGTVMR 24 2 P0DP25;P0DP24;P0DP23;E7EMB3;M0QZ52;F8WBR5;G3V479 P0DP25 CALM2;CALM3;CALM1 1 1025265000.0 247164000.0 492150000.0 285951000.0 True False 319958670.3308234 464761419.865381 233910852.1050313 1.0 1.4525670436898548 0.731065833794026 28.25331032058777 -6.737140728510063 1.6972265226933534 1.270166971068621 0.7309071166753187 0.5919923486603942 0.19016669871412406 0.32302398877299876 1.8259072099261604 0.08868115979569494 0.21829716309902125 1.8317207765486916e-07 6.737140728510063 -0.5392598543933023 EAGAGGLAIAVEGPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAGAGGLAIAVEGPSK 16 0 P21333-2;P21333;Q60FE5;H0Y5C6 P21333-2 FLNA Filamin-A 0 6828300.0 1708300.0 2917400.0 2202600.0 False True 2239597.8432007297 2482135.2919361293 1974696.080831108 1.0 1.1082950894383683 0.8817190491704366 21.094808265130194 -6.776733473847222 1.5484861053062664 1.0615812731990866 0.880101956889703 0.7556599119634285 0.04573790513315895 0.2557051590502406 1.2107886704013848 0.02326900327167839 0.05505944753079059 1.6721164759470738e-07 6.776733473847222 -0.18147931630938352 EAGAGGLAIAVEGPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAGAGGLAIAVEGPSK 16 0 P21333-2;P21333;Q60FE5;H0Y5C6 P21333-2 FLNA Filamin-A 0 3879700.0 0.0 1074700.0 2805000.0 False True 0.0 1503833.3144864633 2070286.3518037573 0.0 EAGAGGLAIAVEGPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAGAGGLAIAVEGPSK 16 0 P21333-2;P21333;Q60FE5;H0Y5C6 P21333-2 FLNA Filamin-A 0 6599500.0 1708300.0 2547600.0 2343600.0 False True 2339904.6750716534 2435038.6082133893 1790089.9479570834 1.0 1.040657183241374 0.7650268692686237 21.158018326653085 -6.869391151939219 1.1372405428776324 1.022914166673768 0.7490653842554595 0.9640754264584476 0.02302686451737198 0.13744374297085954 0.332598718695684 0.015719123103864946 0.037178812675322546 1.3508553529043286e-07 6.869391151939219 -0.27384878241830846 EAGDVCYADVYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAGDVCYADVYR 12 0 J3KTL2;Q07955;Q07955-3;Q07955-2;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 40372800.0 4708800.0 13416000.0 22248000.0 False True 6173282.400084062 11414385.095158411 19945990.377885494 1.0 1.8489977220227252 3.231018619464726 22.55760635904599 -6.96386252497382 0.3770646970258513 0.901879173472418 4.226782156973383 0.9998877438404673 0.009741489686967978 0.07834909972734382 0.016234106233008614 0.018043820799110714 0.11694674596018625 1.0867695838537209e-07 6.96386252497382 3.324902983500965 EAGDVCYADVYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAGDVCYADVYR 12 0 J3KTL2;Q07955;Q07955-3;Q07955-2;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 19233000.0 10630000.0 1822300.0 6780700.0 False True 10292556.46856782 2549953.893168956 5004631.25336033 1.0 0.24774737947333067 0.4862379204470578 23.29509802802246 -10.178202608150151 5.311222205743897 1.0000273312941712 0.36699264996205666 0.903783313726561 0.09736335564502331 3.151154845960003e-05 4.875737128659088e-06 0.09427572260685355 0.03142388791190311 6.63433491539562e-11 10.178202608150151 -0.6330346813321146 EAGDVCYADVYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAGDVCYADVYR 12 0 J3KTL2;Q07955;Q07955-3;Q07955-2;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 32824800.0 4708800.0 12494000.0 15622000.0 False True 6449770.610535273 11941973.767867044 11932405.345189266 1.0 1.8515346496758536 1.8500511205310886 22.620816420568882 -10.172381725882095 4.294295639419158 0.9997624426351945 1.8507928851518989 0.9999977194245895 0.0006056484001669211 283069.9069612144 274735.5355078327 775.5779649072684 0.00022164458570553275 6.72385399077909e-11 10.172381725882095 0.8510304425167043 EAGEANK(ub)AIQDHLLEVEQSKDQMEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAGEANKAIQDHLLEVEQSKDQMEK 25 2 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 18168600.0 4950500.0 6775500.0 6442600.0 True False 6408519.838943944 6398437.468856831 5270112.906658392 1.0 0.998426724057895 0.8223603950841246 22.611559748695033 -6.908856559715245 0.9034860413658824 1.0056504554263712 0.8001546078787578 0.9904828699086136 0.008133395212993003 0.10517901939087207 0.1429045714532931 0.006621499762740807 0.018136728355681548 1.2335121746268722e-07 6.908856559715245 -0.2054958475476134 EAGFLMGASCGGGNMK(ub)VDDSAYESLGLRPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAGFLMGASCGGGNMKVDDSAYESLGLRPR 30 2 O75808 O75808 CAPN15 Calpain-15 1 63686300.0 3140300.0 23971000.0 36575000.0 True False 4764064.6866819095 19693187.763722178 29345935.218608033 1.0 4.133694451877426 6.159852384172177 22.183761571636534 -8.27581276192356 0.2901089003031162 1.2772684372039965e-24 7.418195085352715 0.9990004550025174 0.06710769381022891 0.10298761193396797 0.07087748390423981 0.5988302996392358 0.6428393047205614 5.298918477741456e-09 8.27581276192356 7.418195085352715 EAGFLMGASCGGGNMK(ub)VDDSAYESLGLRPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAGFLMGASCGGGNMKVDDSAYESLGLRPR 30 2 O75808 O75808 CAPN15 Calpain-15 1 52016300.0 3140300.0 18963000.0 29913000.0 True False 4065180.254567346 17907692.38018329 24469140.933299024 1.0 4.405141041424543 6.019201954404665 21.954887893728984 -8.80395886589848 0.33288207067327324 2.3277997184286014e-16 6.611329845237847 0.9982136783498798 0.08842309522218875 0.3364236709589724 0.10944071752443069 0.9266699576997914 0.48412309348427157 1.570511547927767e-09 8.80395886589848 6.611329845237847 EAGITEK(ub)VVFEQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAGITEKVVFEQTK 14 1 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 1 12219600.0 3681100.0 2338900.0 6199600.0 True False 3564245.4954322693 3272834.967202371 4575738.775986655 1.0 0.9182406126055702 1.2837888921654406 21.765165278475006 -6.847984366656806 1.244698736396311 0.9564324210183615 1.2978498802303544 0.9373306283727287 0.039214930761602165 0.1596891551610978 0.4770892440262906 0.024664719322863706 0.05700970155191245 1.4191086045682657e-07 6.847984366656806 0.34141745921199296 EAGITEK(ub)VVFEQTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAGITEKVVFEQTK 14 1 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 1 11789900.0 3681100.0 3188800.0 4920000.0 True False 3060997.750380246 3171621.3014727575 5948749.252490257 1.0 1.0361397034933364 1.9434020334550348 21.545570553909283 -6.9152950254266425 0.8588993747474207 0.9763912551951424 2.074965494100733 0.9927709644315743 0.037109052429347665 0.10101977593498959 0.1205455936313914 0.031200706325470565 0.08964080853447709 1.2153601003320112e-07 6.9152950254266425 1.0985742389055906 EAGVEMGDEDDLSTPNEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAGVEMGDEDDLSTPNEK 18 0 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 6798200.0 1361400.0 3007800.0 2429000.0 False True 1784808.5838163556 2559047.964312569 2177670.380613262 1.0 1.4337940704210985 1.2201142466251882 20.767337926499092 -10.115580888872842 4.292536317017769 0.9999532726946191 1.326954158386033 0.7573792365080735 0.08723442294028222 30408185.89763719 1.7909490888976034 15703.565704457927 0.029862663246448158 7.663357941358916e-11 10.115580888872842 0.32700088569141383 EAGVEMGDEDDLSTPNEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAGVEMGDEDDLSTPNEK 18 0 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 7129600.0 1361400.0 3726200.0 2042000.0 False True 1864746.3704516515 3561564.1631043856 1559721.6563101066 1.0 1.9099456202409746 0.8364256292572023 20.830547988021983 -6.682120404029668 1.8945665545160244 1.5746500159653185 0.8404670068277997 0.3337163317488737 0.3854818672034634 0.43385625672076816 3.0126979564521763 0.16316293664320716 0.4291323066128658 2.079120190822473e-07 6.682120404029668 -0.7341830091375188 EAHEPLAVADAK(ub)LGGVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAHEPLAVADAKLGGVIK 18 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 1 21526300.0 3167800.0 4676500.0 13682000.0 True False 4100779.5466733873 4416248.664026118 11192016.389175197 1.0 1.0769290603803963 2.7292411751941956 21.967466757400466 -6.916620490547674 0.8494068134185769 0.9589162626976622 2.976032148619992 0.993189649325603 0.06582662793144332 0.10020142428730783 0.11621720641905153 0.05572382504211878 0.16188948806339043 1.2116564804807035e-07 6.916620490547674 2.0171158859223297 up EAHGIVVTDVAFLPEK(ub)GR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAHGIVVTDVAFLPEKGR 18 1 Q9HCU5;B5MC98;H7C0W3 Q9HCU5 PREB Prolactin regulatory element-binding protein 1 36894900.0 3948900.0 15565000.0 17381000.0 True False 5990770.003260267 12787304.140099917 13945637.731637064 1.0 2.1345009294532877 2.327853969364145 22.514310016159673 -10.6264294328796 0.35545811493409185 4.892628515954334e-13 2.360532441505119 0.9992220341795081 0.016337089620929886 2.1920311287240937 0.17153715023784497 1.9837993034836172 0.05637518254626987 2.3635814187341732e-11 10.6264294328796 2.36053244150463 EAHGIVVTDVAFLPEK(ub)GR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAHGIVVTDVAFLPEKGR 18 1 Q9HCU5;B5MC98;H7C0W3 Q9HCU5 PREB Prolactin regulatory element-binding protein 1 23933200.0 3948900.0 9848300.0 10136000.0 True False 5111928.894456266 9300233.447648546 8291352.0041426625 1.0 1.8193197987817025 1.6219615286774403 22.285436338252122 -10.44886477295362 4.5136013289700525 0.9976551553715398 1.720640663730339 0.9467441841552718 0.08057117638158162 0.0019061982082424075 0.00023275693617347487 0.07821944707357625 0.026004235358816904 3.5574206936752806e-11 10.44886477295362 0.7229855083587993 EAHQLFLEPEVLDPESVELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAHQLFLEPEVLDPESVELK 20 0 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 0 16043300.0 4919100.0 4262700.0 6861500.0 False True 4762945.863079202 5964818.339686836 5064267.309412289 1.0 1.2523380511049171 1.0632636723144036 22.183422720060324 -10.439316432005604 3.570563596345078 0.9984312910885044 1.1578008617488484 0.48152562537030685 0.07718929204899713 27767763.945554674 727.3025149492121 358623.606863292 0.026423889811563593 3.636499799767589e-11 10.439316432005604 0.15936957066034407 EAIEGTYIDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAIEGTYIDK 10 0 P62280;M0QZC5 P62280 RPS11 40S ribosomal protein S11 0 13209600.0 2800600.0 4861300.0 5547700.0 False True 3671613.721048977 4136012.9891989795 4973677.221296084 1.0 1.1264836944822518 1.3546297620532664 21.80798285464425 -6.962013286769668 0.40606661021640617 0.9882676320164236 1.5012585445177729 0.9998377283292869 0.0018693355405912328 0.07898965477371366 0.01853073598762578 0.002935514682081437 0.01907346084053907 1.0914069455236322e-07 6.962013286769668 0.5129909125013492 EAIEGTYIDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAIEGTYIDK 10 0 P62280;M0QZC5 P62280 RPS11 40S ribosomal protein S11 0 6038900.0 0.0 1182600.0 4856300.0 False True 0.0 1654818.3471775297 3584289.344122839 0.0 EAIEGTYIDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAIEGTYIDK 10 0 P62280;M0QZC5 P62280 RPS11 40S ribosomal protein S11 0 8349000.0 2800600.0 2825100.0 2723300.0 False True 3836057.5033692424 2700277.740643604 2080112.6281240515 1.0 0.7039200372444696 0.5422527233486648 21.871192916167143 -13.99999871084471 0.0738302822225375 2.6647764901501505 2.5608232497200367e-08 0.999912698308809 0.0017709743354612467 12.23291075496494 0.07407640423229939 3.430390007983662 0.49312295463002415 1.0000029683941571e-14 13.99999871084471 -2.664776464541918 EAIEGTYIDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAIEGTYIDKK 11 1 P62280;M0QZC5 P62280 RPS11 40S ribosomal protein S11 0 12528200.0 1041000.0 5340900.0 6146300.0 False True 1364761.0810583415 4544058.538665147 5510339.835472742 1.0 3.3295633951851347 4.037585707821912 20.380216980292378 -9.552046010131367 0.3461203395908101 2.026799295908056e-20 4.21379800398528 0.9984994184231446 0.050267557196539824 0.9077706488435613 0.14223392893303363 1.2737380246852594 0.210111675628673 2.80513643976381e-10 9.552046010131367 4.21379800398528 EAIEGTYIDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAIEGTYIDKK 11 1 P62280;M0QZC5 P62280 RPS11 40S ribosomal protein S11 0 14724800.0 1041000.0 6669000.0 7014800.0 False True 1425885.831967217 6374341.528566149 5358048.714340908 1.0 4.470443134827855 3.7576982632253952 20.44342704181527 -10.454772547997349 8.497563415710552 0.9999275191081168 4.114070699026625 0.9621961405331283 0.29097687536858974 0.00039956523296547314 2.5637331918133273e-05 0.28174313688246505 0.09391238270283493 3.509356204988062e-11 10.454772547997349 3.114143179918508 EAIHALSSSEDGGHIFCTLESLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAIHALSSSEDGGHIFCTLESLKR 24 1 Q9Y4R8;H3BRS3 Q9Y4R8 TELO2 Telomere length regulation protein TEL2 homolog 1 104184400.0 6805300.0 8242100.0 89137000.0 True False 8809595.002517978 7783419.889611808 72914980.62285545 1.0 0.8835161988022302 8.276768750665012 23.070644265962574 -6.903323025740341 0.9400364746333717 0.7200095355351529 9.107341578267349 0.988147851379442 0.37647323360986407 0.10899993557636839 0.16395228955455118 0.2983905380665004 0.7901258966773905 1.2493294404891857e-07 6.903323025740341 8.387332042732195 up EAILAIHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAILAIHK 8 0 O43707;O43707-2;O43707-3;F5GXS2;H7C144 O43707 ACTN4 Alpha-actinin-4 0 8853800.0 2266600.0 2407600.0 4179600.0 False True 2971534.5497856257 2048395.4647512962 3747135.085554217 1.0 0.6893392724977985 1.2610101019436388 21.502776724465768 -6.759095593683955 1.6155887296943818 0.8193538303846092 1.263027651043263 0.6874049847351358 0.13064919638459604 0.2844241968456871 1.4629120593613478 0.06380816988806386 0.1534958216349316 1.7414235219583296e-07 6.759095593683955 0.4436738206586538 EAILAIHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAILAIHK 8 0 O43707;O43707-2;O43707-3;F5GXS2;H7C144 O43707 ACTN4 Alpha-actinin-4 0 4962730.0 1687600.0 794630.0 2480500.0 False True 1634028.061745537 1111929.902940706 1830782.6365950832 1.0 0.6804839702403249 1.120410768612728 20.64000132893598 -6.7119327872131365 1.7883016122942734 0.8039525139366649 1.1194358878960273 0.47420476159119695 0.13460318681065447 0.3712449314043686 2.315511749911759 0.0598710271942092 0.15174591218943645 1.9411862784714056e-07 6.7119327872131365 0.31548337395936243 EAILAIHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAILAIHK 8 0 O43707;O43707-2;O43707-3;F5GXS2;H7C144 O43707 ACTN4 Alpha-actinin-4 0 15773900.0 2049200.0 12092000.0 1632700.0 False True 3108786.216587132 9934088.124772783 1309996.1293621697 1.0 3.1954877024894177 0.4213850802517715 21.567919978903085 -6.6957590989509095 1.845845148492889 2.3689257901462724 0.4302252797145444 0.39754038385156976 0.9274799585422189 0.40441437884754317 2.675718281228914 0.40130622089698326 1.0375478031356637 2.014841562821868e-07 6.6957590989509095 -1.9387005104317279 EAILAIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAILAIHK 8 0 O43707;O43707-2;O43707-3;F5GXS2;H7C144 O43707 ACTN4 Alpha-actinin-4 0 9177500.0 2266600.0 3060400.0 3850500.0 False True 3104623.272561857 2925181.4086105614 2941091.2035367624 1.0 0.9422017268448727 0.9473262761152492 21.56598678598866 -10.086635992713305 4.842144923935474 1.0000020872829123 0.944764001479546 0.9935858825032324 0.0020920884808047404 4.7141995995033976e-08 8.896205386261114e-09 0.0020257324802614627 0.0006752186534930363 8.19151078311313e-11 10.086635992713305 -0.05523808580336631 EAINVEQAFQTIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAINVEQAFQTIAR 14 0 P51149;C9J8S3;C9J4V0;C9J4S4 P51149 RAB7A Ras-related protein Rab-7a 0 3973050.0 430350.0 1606400.0 1936300.0 False True 564193.0175153288 1366731.381698157 1735950.2503011338 1.0 2.4224535562619285 3.076872978588341 19.10582928559542 -9.337064439398874 0.2403282447081723 5.257766768540182e-21 3.5305444613464663 0.9991865349470987 0.024727680263068243 0.7525584301192292 0.09143695077548641 0.8856393802412823 0.2970555651621926 4.601882870662379e-10 9.337064439398874 3.5305444613464663 EAINVEQAFQTIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAINVEQAFQTIAR 14 0 P51149;C9J8S3;C9J4V0;C9J4S4 P51149 RAB7A Ras-related protein Rab-7a 0 3961250.0 430350.0 1978300.0 1552600.0 False True 589462.024771462 1890892.1646367349 1185907.85680072 1.0 3.207826942490223 2.0118477645112147 19.16903934711831 -10.27659177361301 5.869356819289162 0.9999086221404372 2.6098373535007267 0.7072402015356879 0.4882564548403348 0.00058385463171792 7.196163939974517e-05 0.47277838191670507 0.1575840931895701 5.289422111539481e-11 10.27659177361301 1.6099287313602895 EAIQHPADEK(ub)LQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAIQHPADEKLQEK 14 1 Q9NUQ9;E5RI16;E5RGI7;E5RJE1;E5RIR8;E5RJL8 Q9NUQ9 FAM49B Protein FAM49B 1 8095000.0 3777000.0 3001500.0 1316500.0 True False 4951683.576520035 2553687.8997553666 1180281.2087597197 1.0 0.5157211401521052 0.23835957821626452 22.239487695433134 -8.783229630640284 0.22713135374057103 1.3129364630129492 4.512890626936181e-21 0.9994411408150141 0.007440515892997532 0.3138516674387094 0.06839275091198364 0.19667461129747243 0.12208436889428008 1.6472911657509651e-09 8.783229630640284 -1.3129364630129492 down EAIQHPADEK(ub)LQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAIQHPADEKLQEK 14 1 Q9NUQ9;E5RI16;E5RGI7;E5RJE1;E5RIR8;E5RJL8 Q9NUQ9 FAM49B Protein FAM49B 1 8698900.0 3777000.0 2749200.0 2172700.0 True False 5173458.969587108 2627731.2536113393 1659553.0081611003 1.0 0.50792540717126 0.32078209529002 22.302697756956025 -13.99993933960921 0.13401579121071652 3.341141415461801 0.07159254972726499 0.9996278340501601 0.005526131180560053 11.932300390043585 0.114219804375941 7.3340958055955285 0.22199575877464653 1.0001396854666757e-14 13.99993933960921 -3.269548865734536 EAIQHPADEK(ub)LQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAIQHPADEKLQEK 14 1 Q9NUQ9;E5RI16;E5RGI7;E5RJE1;E5RIR8;E5RJL8 Q9NUQ9 FAM49B Protein FAM49B 1 1459500.0 0.0 0.0 1459500.0 True False 0.0 0.0 1764674.7020344543 0.0 EAIQK(ub)SVTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAIQKSVTR 9 1 Q969H6-2;Q969H6 Q969H6-2 POP5 Ribonuclease P/MRP protein subunit POP5 1 14460200.0 0.0 4929300.0 9530900.0 True False 0.0 4654980.121797058 7796373.995292341 0.0 EAITHLLGVALTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAITHLLGVALTR 13 0 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 0 7899000.0 2602800.0 2319700.0 2976500.0 False True 3412296.005551058 1973609.802119781 2668520.332604105 1.0 0.5783817696088354 0.782030728947022 21.70231137049903 -10.150693979348116 4.963841643288056 1.000018074813684 0.6802062492798112 0.7667838310280228 0.08313933951113715 1.7901890730922167e-05 3.0629774468758662e-06 0.08050421315561893 0.02683310644414039 7.068154282593367e-11 10.150693979348116 -0.3198118255338728 EAITHLLGVALTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAITHLLGVALTR 13 0 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 0 1238000.0 0.0 1238000.0 0.0 False True 0.0 1732339.8560847135 0.0 0.0 EAITHLLGVALTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAITHLLGVALTR 13 0 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 0 10639100.0 2602800.0 3773200.0 4263100.0 False True 3565125.4980252376 3606487.5476961704 3256243.5813004994 1.0 1.011601849554481 0.9133601560742164 21.76552143202192 -6.877439390362295 1.093938532594632 1.0069743515990466 0.9067297370769695 0.9715624963192004 0.0073918507806989475 0.12992448241551724 0.2861746951522845 0.005216426233658551 0.012536992439898807 1.3260521671608142e-07 6.877439390362295 -0.10024461452207711 EAIVAALLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAIVAALLTR 10 0 Q96GQ7;B7Z6D5 Q96GQ7 DDX27 Probable ATP-dependent RNA helicase DDX27 0 5249700.0 1166700.0 1613000.0 2470000.0 False True 1529554.9983388702 1372346.6874247566 2214428.0939130303 1.0 0.8972195762265199 1.4477597054816251 20.54468055226096 -6.8584511423074135 1.1934878169935694 0.9444459083248876 1.4736474050447232 0.9517314572818548 0.05251150805713816 0.14841071209038154 0.4025732277426792 0.0343365519322065 0.08001976790822726 1.3853160238184155e-07 6.8584511423074135 0.5292014967198356 EAIVAALLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAIVAALLTR 10 0 Q96GQ7;B7Z6D5 Q96GQ7 DDX27 Probable ATP-dependent RNA helicase DDX27 0 4572900.0 1166700.0 1239300.0 2166900.0 False True 1598060.518881987 1184543.6281829402 1655122.8487063532 1.0 0.7412382786426975 1.0357072395883276 20.60789061378385 -6.674639156014984 1.9208454055759836 0.8354936577074809 1.0345451154808596 0.29970964267450506 0.10980093718607159 0.45060248168331984 3.20950478751473 0.04594666316699752 0.12202384364868601 2.1152458126158715e-07 6.674639156014984 0.19905145777337874 EAK(ub)AGEAPTENPAPPTQQSSAE ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAKAGEAPTENPAPPTQQSSAE 22 1 P16989;P16989-2 P16989;P16989-2 YBX3 Y-box-binding protein 3 1 3341900.0 1235800.0 1514600.0 591500.0 True False 1620145.7675042234 1288627.5838645594 530297.2540686472 1.0 0.7953775578166921 0.3273145322507314 20.6276921902086 -6.957336265888193 0.47147644461104526 1.0121871092501071 0.09126887348911168 0.9996582942243123 0.005204621748061226 0.08066673149261361 0.02475382158638001 0.0064898227478402525 0.03862789009128923 1.1032240838694486e-07 6.957336265888193 -0.9209182357609954 down EAK(ub)AGEAPTENPAPPTQQSSAE ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAKAGEAPTENPAPPTQQSSAE 22 1 P16989;P16989-2 P16989;P16989-2 YBX3 Y-box-binding protein 3 1 5492900.0 1853100.0 1596600.0 2043200.0 True False 1794274.3548356544 2234130.7061590054 1508024.6253138778 1.0 1.2451444229461996 0.840464905074121 20.774969072791194 -6.742715130618532 1.676700963431996 1.1454013878679412 0.8400828539248837 0.6170557789465603 0.10299561772599351 0.3129442707611101 1.7284627122574125 0.04857453366375741 0.11884666204952707 1.8083599054177586e-07 6.742715130618532 -0.3053185339430575 EAK(ub)AGEAPTENPAPPTQQSSAE ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAKAGEAPTENPAPPTQQSSAE 22 1 P16989;P16989-2 P16989;P16989-2 YBX3 Y-box-binding protein 3 1 8326500.0 2853100.0 4226800.0 1246600.0 True False 4328361.289549462 3472494.5158608686 1000208.9635958095 1.0 0.802265403362925 0.2310825960879807 22.04538949568093 -6.95492161098664 0.5339973818404999 1.0087208136178953 4.398697152233153e-16 0.9993708355675059 0.008177527060974889 0.0820936191906708 0.03224994023898166 0.009085625926434965 0.04695499336608823 1.1093750364725969e-07 6.95492161098664 -1.008720813617895 down EAK(ub)AGEAPTENPAPPTQQSSAE ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAKAGEAPTENPAPPTQQSSAE 22 1 P16989;P16989-2 P16989;P16989-2 YBX3 Y-box-binding protein 3 1 3532960.0 1235800.0 1303300.0 993860.0 True False 1692708.6562392744 1245715.8965632415 759130.7371892079 1.0 0.73593048158144 0.44847099611092217 20.69090225173149 -6.970038747882726 0.25726452789422866 1.0834481336688835 0.09245520665861108 0.9999826810320579 0.0009372935763282164 0.07629017704090216 0.008985414107461974 0.00610849029433059 0.027235042675857718 1.0714237082314508e-07 6.970038747882726 -0.9909929270102724 down EAK(ub)AGEAPTENPAPPTQQSSAE ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAKAGEAPTENPAPPTQQSSAE 22 1 P16989;P16989-2 P16989;P16989-2 YBX3 Y-box-binding protein 3 1 4988190.0 1853100.0 2153300.0 981790.0 True False 1540934.7562493884 2141699.7455034168 1187077.7497159352 1.0 1.389870490504271 0.7703621096880598 20.55537434822547 -6.7365917957562225 1.6990819110677935 1.23288317894375 0.7702565750973465 0.5895654972655525 0.16382586428322765 0.3240283918178263 1.8353396242006834 0.07631863157274006 0.1879909994165356 1.8340374701577845e-07 6.7365917957562225 -0.46262660384640353 EAK(ub)EAPAQPAPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAKEAPAQPAPEK 13 1 Q15428;K7EMT0 Q15428 SF3A2 Splicing factor 3A subunit 2 1 5296800.0 1948300.0 2127500.0 1221000.0 True False 2554240.16736404 1810085.292930047 1094662.6326590315 1.0 0.708659003980054 0.4285668382502639 21.28446275292979 -6.986782102434284 0.21788086894264255 1.1335591013488129 5.155732122119603e-09 0.9999924367275583 0.0006415864022574106 0.07413309937272626 0.007126812159604338 0.007864653105759406 0.028031378762344617 1.0309032233977354e-07 6.986782102434284 -1.1335590961930808 down EAK(ub)EQHPDMSVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAKEQHPDMSVTK 13 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;A8K968;A0A0A0MRA8;Q9Y2J2-2;Q9Y2J2;A0A0A0MSA4 P11171;A8K968 EPB41;EPB41L3 Protein 4.1;Band 4.1-like protein 3;Band 4.1-like protein 3, N-terminally processed 1 3572400.0 1225900.0 1168400.0 1178100.0 True False 1607166.7716324858 994079.2743875283 1056201.513133174 1.0 0.6185290113842936 0.6571822736605818 20.616088210921784 -9.92158694534578 6.937751464884281 1.0000000119431298 0.6378556429096206 0.991528208532595 0.015780128245152868 2.9028573371771463e-09 4.4302816946094075e-10 0.01527904404280871 0.005093014491206846 1.1978792848797832e-10 9.92158694534578 -0.3621443690335092 EAK(ub)EQHPDMSVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAKEQHPDMSVTK 13 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;A8K968;A0A0A0MRA8;Q9Y2J2-2;Q9Y2J2;A0A0A0MSA4 P11171;A8K968 EPB41;EPB41L3 Protein 4.1;Band 4.1-like protein 3;Band 4.1-like protein 3, N-terminally processed 1 2027320.0 1394700.0 632620.0 0.0 True False 2115861.8662278303 519724.0183173795 0.0 1.0 0.2456323007720472 0.0 21.01281401368864 -9.096716596885784 0.4680253450727769 1.1280621580772097 3.837556231069179e-24 0.9965663803893793 0.024932708528126585 0.579841279455374 0.20112080232470614 0.20130214405238564 0.05310269303523126 8.003563650128616e-10 9.096716596885784 -1.1280621580772097 EAK(ub)EQHPDMSVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAKEQHPDMSVTK 13 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;A8K968;A0A0A0MRA8;Q9Y2J2-2;Q9Y2J2;A0A0A0MSA4 P11171;A8K968 EPB41;EPB41L3 Protein 4.1;Band 4.1-like protein 3;Band 4.1-like protein 3, N-terminally processed 1 1114110.0 543360.0 383870.0 186880.0 True False 451827.91492939845 381802.0161177709 225955.74396450803 1.0 0.8450164398926755 0.5000924832185619 18.78541388081658 -6.9579024261028 0.46405162391965105 1.0096572881038974 0.32145221138322216 0.9996843167298907 0.0037123165261282415 0.08045909895378922 0.023965612234489418 0.004717559728036394 0.028482464129844856 1.1017868226063632e-07 6.9579024261028 -0.6882050767206753 EAK(ub)EQHPDMSVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAKEQHPDMSVTK 13 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;A8K968;A0A0A0MRA8;Q9Y2J2-2;Q9Y2J2;A0A0A0MSA4 P11171;A8K968 EPB41;EPB41L3 Protein 4.1;Band 4.1-like protein 3;Band 4.1-like protein 3, N-terminally processed 1 5035800.0 1394700.0 1246200.0 2394900.0 True False 1805466.643647127 1176847.8745021583 1959052.7737491357 1.0 0.6518247671000282 1.0850672764531155 20.78394033578109 -6.692795623365924 1.8566534409193625 0.7822855032099963 1.0836142715067978 0.3834286465640634 0.14717190541483055 0.41070692754219995 2.7471011536468923 0.06336443005032129 0.16441587839208407 2.0286371606011045e-07 6.692795623365924 0.30132876829680144 EAK(ub)ESFQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAKESFQR 8 1 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 2803700.0 496620.0 738880.0 1568200.0 True False 651073.629274921 628641.9841316818 1405937.7072366045 1.0 0.9655466845305645 2.1594143028068125 19.31246118001382 -6.900254089309414 0.9596498872020333 0.9507088189375537 2.2853840242944696 0.9866925941442509 0.06400648734944679 0.11121883963877316 0.17636247990373619 0.049999231665242096 0.13025755187796578 1.2581890774741354e-07 6.900254089309414 1.334675205356916 up EAK(ub)ESFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAKESFQR 8 1 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 2143950.0 526260.0 888570.0 729120.0 True False 509554.1643601594 1243380.634831336 538141.5988688612 1.0 2.440134379811483 1.056102837555255 18.958875983929886 -6.636872134205171 2.0554418763530453 1.9439840650311653 1.0617896702825471 0.14278740621911212 0.6166733110679558 0.5413444177944772 4.367063318264519 0.24462998236478373 0.6830065659813016 2.3074264455372137e-07 6.636872134205171 -0.8821943947486182 EAK(ub)ESFQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAKESFQR 8 1 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 1591810.0 526260.0 661900.0 403650.0 True False 437608.50727095315 658334.213323136 488051.348733271 1.0 1.5043908022462564 1.115269334631754 18.739281259364162 -9.915659732895694 6.078122302877637 0.9999999204995744 1.3098300684390858 0.45808533192145984 0.15885817393669746 1.712821586420339e-07 3.0544366349233295e-08 0.15381380448018792 0.05127125517210372 1.2143399058273034e-10 9.915659732895694 0.30983014793951136 EAK(ub)LYTINK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAKLYTINK 9 1 Q86XI2;Q86XI2-2;H0Y6U5 Q86XI2 NCAPG2 Condensin-2 complex subunit G2 1 9513300.0 1251300.0 1986600.0 6275400.0 True False 1898313.582283566 1632075.708623354 5035064.439394466 1.0 0.8597503193650743 2.6523881440797377 20.856286900058905 -6.887994076578765 1.0342021837453244 0.8989963133009464 2.800631035560859 0.9795820429592925 0.11631598230275779 0.1207846794578265 0.23148868563098315 0.08591484819062606 0.21269213981737897 1.29421349334226e-07 6.887994076578765 1.9016347222599124 up EAK(ub)LYTINK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAKLYTINK 9 1 Q86XI2;Q86XI2-2;H0Y6U5 Q86XI2 NCAPG2 Condensin-2 complex subunit G2 1 7988900.0 1251300.0 0.0 6737600.0 True False 1619832.5168105364 0.0 5511425.933614004 1.0 0.0 3.4024665367664353 20.627413222151354 -6.828006863057405 1.3367782980386849 0.46488693375112367 3.4903613705411063 0.9018329749582693 0.44736634637737305 0.18328292484032058 0.6412445433649832 0.26281377380084725 0.6048828998019616 1.4859121605678964e-07 6.828006863057405 3.025474436789983 EAK(ub)PGAAEPEVGVPSSLSPSSPSSSWTETDVEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAKPGAAEPEVGVPSSLSPSSPSSSWTETDVEER 34 1 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 1 19265500.0 6918400.0 5483700.0 6863400.0 True False 6698779.178940697 7673370.00711772 5065669.642413508 1.0 1.1454878272806628 0.7562078861083702 22.67546676445128 -6.805465816214421 1.4333000717036266 1.0797251539466495 0.7500681542380124 0.8477124382122876 0.0626738125644805 0.21304723599400321 0.8633840299413569 0.03438962811045939 0.07973359222601246 1.5650715028374392e-07 6.805465816214421 -0.32965699970863704 EAK(ub)PGAAEPEVGVPSSLSPSSPSSSWTETDVEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAKPGAAEPEVGVPSSLSPSSPSSSWTETDVEER 34 1 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 1 13181500.0 3809200.0 6811200.0 2561100.0 True False 5217564.179759386 6510258.662373623 1956220.927510195 1.0 1.2477582331673112 0.37492992134126624 22.314945010996034 -6.830859195381438 1.3239613258020657 1.1323142658219558 0.3510117436607868 0.9075922862346631 0.11164234896363487 0.17976084882014293 0.6159298877031466 0.0661999411030643 0.15235019769727656 1.4761850564704182e-07 6.830859195381438 -0.781302522161169 down EAK(ub)PGAAEPEVGVPSSLSPSSPSSSWTETDVEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAKPGAAEPEVGVPSSLSPSSPSSSWTETDVEER 34 1 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 1 16238800.0 6918400.0 6443300.0 2877100.0 True False 5752956.137086925 6408588.66400509 3478688.3077926263 1.0 1.113964457801368 0.6046783992262628 22.455872039885556 -6.847977858088802 1.2449722049308234 1.060722375096774 0.5851178206749753 0.937286232481747 0.05465201895852829 0.15969834293957091 0.47736772875962213 0.034369231562615024 0.0794288361034672 1.4191298722436636e-07 6.847977858088802 -0.4756045544217987 EAK(ub)PGAAEPEVGVPSSLSPSSPSSSWTETDVEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAKPGAAEPEVGVPSSLSPSSPSSSWTETDVEER 34 1 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 1 30302600.0 11646000.0 13563000.0 5093600.0 True False 15075976.57698033 12808207.127164796 4166617.064749507 1.0 0.8495772769189482 0.2763746045554063 23.845748122863153 -6.945989951386947 0.6012600569375243 1.006438829820813 0.09010705326352363 0.9988478271554172 0.010582721066779304 0.08513707440961593 0.04294254391730515 0.010848039482136945 0.04819035802414968 1.132426564776653e-07 6.945989951386947 -0.9163317765572893 down EAK(ub)SETSGPQIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAKSETSGPQIK 12 1 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 1 1765950.0 677150.0 656010.0 432790.0 True False 655654.2439031696 917958.2140469564 319429.31557830545 1.0 1.4000644738944528 0.4871917150672488 19.322575691553862 -6.7875833314058385 1.5060043199483506 1.2242977645444635 0.4781215955321106 0.7934034479398177 0.16982336138968032 0.2389655478366566 1.0707467117772451 0.08877225544518756 0.20820673847835047 1.6308599536241572e-07 6.7875833314058385 -0.746176169012353 down EAK(ub)SETSGPQIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAKSETSGPQIK 12 1 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 1 2687140.0 757300.0 650840.0 1279000.0 True False 980339.7786147352 614620.1818656594 1046235.1236482295 1.0 0.6269460806070174 1.0672168430486493 19.902922337912948 -6.682122330047582 1.894010781080563 0.7644237928328924 1.0655847103447285 0.3340505207438993 0.1580348229621607 0.4338040052942937 3.0104205067988237 0.0669027685390163 0.1759949346031138 2.079110970318828e-07 6.682122330047582 0.30116091751183605 EALAEAALESPRPALVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EALAEAALESPRPALVR 17 1 O14745;O14745-2;J3QRP6 O14745 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 0 5643100.0 1359800.0 2681200.0 1602100.0 False True 1782710.9683219315 2281175.411235742 1436330.0604283668 1.0 1.2796103528678098 0.8056999064634613 20.76564138649363 -6.746830743184875 1.66150132447288 1.165039586753705 0.80497799367862 0.6352237694994685 0.11748079740051566 0.3056200949816435 1.6589289659149902 0.05587911156040277 0.1361177319939599 1.791303839669941e-07 6.746830743184875 -0.3600615930750849 EALAEAALESPRPALVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EALAEAALESPRPALVR 17 1 O14745;O14745-2;J3QRP6 O14745 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 0 5487400.0 2264500.0 1089300.0 2133600.0 False True 2192614.6870246334 1524263.1706244552 1574746.153372011 1.0 0.6951805894782509 0.7182046908154817 21.064220875654105 -10.689791153321199 6.686015612571783 1.0024732144119477 0.7066926401468665 0.9953997818913357 0.0093995500103912 0.00034894416018583173 1.6189816181449676e-05 0.009164537735313982 0.003033691721007404 2.042720026529988e-11 10.689791153321199 -0.2957805742650812 EALAEAALESPRPALVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EALAEAALESPRPALVR 17 1 O14745;O14745-2;J3QRP6 O14745 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 0 6146300.0 1359800.0 2523900.0 2262600.0 False True 1862554.8072132752 2412385.7525788117 1728220.4797097177 1.0 1.295202558999155 0.9278763089368917 20.828851448016522 -6.692700076052618 1.8562805363598804 1.184590677264919 0.9290811665987 0.3834285478981463 0.12478036118725121 0.4108400062440996 2.7466369353726776 0.05372771992635986 0.1394642734785053 2.0290835216808886e-07 6.692700076052618 -0.2555095106662191 EALAFIIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EALAFIIR 8 0 B5MCF9;O00541-2;O00541;B3KXD6 B5MCF9 PES1 Pescadillo homolog 0 8638100.0 2927300.0 2990000.0 2720800.0 False True 3837718.648013521 2543903.6549287136 2439277.7157565085 1.0 0.662868721823964 0.6356061867690918 21.871817517440533 -13.999999999999998 0.3564346885134988 5.314375315638721 0.6321543138308902 0.9997667739933958 0.0025309054810168743 21.31779435497762 0.19266947490472144 69.84784422676952 0.007959985625735867 1.0000000000000041e-14 13.999999999999998 -4.6822210018078305 EALAFIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EALAFIIR 8 0 B5MCF9;O00541-2;O00541;B3KXD6 B5MCF9 PES1 Pescadillo homolog 0 2927300.0 2927300.0 0.0 0.0 False True 4009601.917307998 0.0 0.0 1.0 0.0 0.0 21.935027578963425 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 EALEHK(ub)DREDYVPYTGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EALEHKDREDYVPYTGEK 18 2 Q9NYL9 Q9NYL9 TMOD3 Tropomodulin-3 1 30426300.0 4576300.0 14069000.0 11781000.0 True False 5924110.562359192 13286047.782355048 9636978.883268027 1.0 2.2427076001539157 1.6267385258640814 22.498167135386257 -10.076977824413133 5.5836887230283585 0.9999934413502474 1.9347230630092722 0.7543204341584482 0.2514683215583979 2.0531586733899615e-05 3.39451012001154e-06 0.24348486610904754 0.0811610517910604 8.375720484485922e-11 10.076977824413133 0.9347296216590248 EALETDLYK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EALETDLYKR 10 1 Q13426-3;Q13426-2;Q13426 Q13426-3 XRCC4 DNA repair protein XRCC4 1 8817940.0 4108900.0 4271100.0 437940.0 True False 3416732.4051336274 4248090.7365530245 529511.2291942241 1.0 1.2433197080843337 0.15497591453127424 21.70418583116683 -6.848016488767481 1.2446349386988977 1.129653434624551 0.11310603950193764 0.9373726240846567 0.11671880805876202 0.15964740813547815 0.4769140464143461 0.07341779614672443 0.16969086951728635 1.419003645652636e-07 6.848016488767481 -1.0165473951226134 down EALEVDWSSEK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EALEVDWSSEKAK 13 1 Q9UBE0;M0QX65;B3KNJ4;Q9UBE0-2;Q9UBE0-3;M0QZS6 Q9UBE0 SAE1 SUMO-activating enzyme subunit 1;SUMO-activating enzyme subunit 1, N-terminally processed 1 9974800.0 4215700.0 3201400.0 2557700.0 True False 3505541.3371758405 3184153.422771856 3092503.244531364 1.0 0.908320032915971 0.8821756604994905 21.741205816457317 -13.999999999999998 0.1759681830798002 1.4700107412444328 0.8605198832441495 0.9995035465801162 0.0011256548859281262 12.155201935117388 0.1329356674839439 1.9517243118863912 0.02021031114363232 1.0000000000000041e-14 13.999999999999998 -0.6094908580002832 EALEVDWSSEK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EALEVDWSSEKAK 13 1 Q9UBE0;M0QX65;B3KNJ4;Q9UBE0-2;Q9UBE0-3;M0QZS6 Q9UBE0 SAE1 SUMO-activating enzyme subunit 1;SUMO-activating enzyme subunit 1, N-terminally processed 1 27764000.0 2930000.0 6001000.0 18833000.0 True False 3792942.758934606 5667039.074697034 15405587.242898453 1.0 1.4941008696605906 4.06164506611898 21.854886168737945 -6.938949366597358 0.6692650651452543 0.9705904591590944 4.733145061363365 0.9980230425985481 0.059671932617410696 0.08824920155548861 0.0568167133285138 0.05763383731638448 0.22202586130650076 1.1509345659573514e-07 6.938949366597358 3.762554602204271 up EALEVDWSSEKAK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EALEVDWSSEKAK 13 1 Q9UBE0;M0QX65;B3KNJ4;Q9UBE0-2;Q9UBE0-3;M0QZS6 Q9UBE0 SAE1 SUMO-activating enzyme subunit 1;SUMO-activating enzyme subunit 1, N-terminally processed 1 18080400.0 2494300.0 2869100.0 12717000.0 True False 3228920.520003609 2709432.0628584023 10402636.48743903 1.0 0.8391138914919386 3.22170719997388 21.622620498722064 -6.8907355790869 1.0179959567220944 0.8742292174835686 3.4296296706587337 0.9813658159773432 0.14841457215526818 0.11854934688052567 0.2183655674126173 0.11097428983661989 0.2774102115809017 1.286069447127273e-07 6.8907355790869 2.555400453175165 up EALICPTCNVTIHNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EALICPTCNVTIHNR 15 0 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974;V9GYF5;V9GYG5;V9GZ14 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 0 7763300.0 1620400.0 3669900.0 2473000.0 False True 2124360.0919759213 3122365.225158155 2217117.6826910623 1.0 1.4697909440832904 1.043663779537896 21.018596901792034 -10.332246077183854 3.7981492573322893 0.9992541464530658 1.2567273618557129 0.3261249301187521 0.17396568659254089 21732317.210891068 29560697.18346274 108004.00892706205 0.05955308164424901 4.6532236080900084e-11 10.332246077183854 0.2574732154026471 EALK(ub)DEANQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EALKDEANQK 10 1 O94782;C9JC88 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 6282340.0 1954830.0 3326000.0 1001510.0 True False 2562801.0606006463 2829773.7646464566 897883.3523622842 1.0 1.1041722309820021 0.35035234149304056 21.289290061990247 -6.871966981542762 1.1236903514521004 1.0596735784841211 0.3045328328891427 0.9666045866017509 0.0609493679677937 0.13498017370240845 0.31735428616837086 0.042043870025621044 0.09989093777626659 1.3428670524945941e-07 6.871966981542762 -0.7551407455949785 down EALK(ub)DEANQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EALKDEANQK 10 1 O94782;C9JC88 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 6817490.0 2946600.0 2899200.0 971690.0 True False 2853061.795887297 4056865.6791282655 717175.2389248459 1.0 1.4219340376630671 0.25137038390078253 21.444079564633096 -6.809184427563684 1.417788024381758 1.2301703315123491 0.23123664886288986 0.8577427806275821 0.18256716593962538 0.2079052825492196 0.8238015393538145 0.10125290901782426 0.23432511842811796 1.5517279129998103e-07 6.809184427563684 -0.9989336826494593 down EALK(ub)DEANQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EALKDEANQK 10 1 O94782;C9JC88 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 9220500.0 2225700.0 1914900.0 5079900.0 True False 3376549.620465538 1573171.133818012 4075855.5384007385 1.0 0.46591085890842404 1.2071066611006251 21.68711832828077 -6.713360638294796 1.78332435445152 0.6727869240331749 1.2055367136778803 0.48102057801858367 0.2249475339101039 0.3683512792362129 2.2855671202420824 0.1003058872309734 0.2537816240102778 1.9348146259070198e-07 6.713360638294796 0.5327497896447054 EALK(ub)DEANQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EALKDEANQK 10 1 O94782;C9JC88 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 4993870.0 1954830.0 2247820.0 791220.0 True False 2677583.478294399 2148503.879853281 604350.1316874053 1.0 0.8024040696657803 0.22570729786261298 21.35250012351314 -6.964049056220411 0.5402171039504011 1.008295151578875 1.0640300101712164e-11 0.9993576004865171 0.008325780564858169 0.08058198224402253 0.032685980761994034 0.009221191252114942 0.04642394327696918 1.0863029121225959e-07 6.964049056220411 -1.0082951515682346 down EALK(ub)PVDSGEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EALKPVDSGEAR 12 1 Q0PNE2;C9IYN7;Q0PNE2-2;C9JLH5;C9JA82;C9J2D6;C9J9N8;C9JEX8 Q0PNE2 ELP6 Elongator complex protein 6 1 13968200.0 1301600.0 986600.0 11680000.0 True False 1684946.8583717654 931694.8427088998 9554359.846920498 1.0 0.5529520637874807 5.670422066695489 20.684271660213497 -6.88561904670857 1.047921274249747 0.6954680309641545 6.074619145403586 0.9779440245496519 0.3436930700059467 0.12277095149332765 0.24317304221399957 0.25122148433950087 0.6172102722595738 1.3013105577118877e-07 6.88561904670857 5.3791511144394315 up EALK(ub)QSATDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EALKQSATDPR 11 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 18634200.0 4439500.0 3998700.0 10196000.0 True False 6735046.070924544 3285100.7430143 8180756.130934441 1.0 0.4877621783756176 1.2146548137586 22.683256383767066 -6.71736795799074 1.7690586853746326 0.6874852491609136 1.213337696535598 0.49997143664493904 0.21562377005139363 0.3604427438272986 2.2031390831477435 0.0968397302215812 0.2438347235796419 1.9170438282384078e-07 6.71736795799074 0.5258524473746844 EALKDEANQK(ub)DK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EALKDEANQKDK 12 2 O94782;C9JC88 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 11234000.0 3522600.0 5630500.0 2080900.0 True False 4618162.712906926 4790451.3475171 1865588.4294022787 1.0 1.037306748445363 0.4039676696943349 22.138887574174714 -6.892917630385469 1.004992558894611 1.0316883144507092 0.346282084388687 0.9827000038612794 0.03816532232160161 0.11680670155249727 0.20828912017140302 0.028819762063386902 0.07264330581902237 1.2796239785258035e-07 6.892917630385469 -0.6854062300620222 down EALKDEANQK(ub)DK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EALKDEANQKDK 12 2 O94782;C9JC88 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 10829000.0 4933100.0 3738600.0 2157300.0 True False 4776501.440742422 5231442.476541448 1592238.4123872498 1.0 1.095245660750458 0.3333482533483262 22.187522869096522 -6.875570935008526 1.1042559937177079 1.0561818738359057 0.28374800339582107 0.9699313438063502 0.0587750017812167 0.13162305971600027 0.29664069633000456 0.04115284925400841 0.09848610381768517 1.3317695014502253e-07 6.875570935008526 -0.7724338704400846 down EALKDEANQK(ub)DK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EALKDEANQKDK 12 2 O94782;C9JC88 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 13568000.0 3894100.0 3534200.0 6139700.0 True False 5907634.39684363 2903494.397169368 4926185.603873897 1.0 0.4914817339950262 0.8338677164087698 22.49414911475974 -9.946146518632895 5.588871872766281 1.0000004347071696 0.6626747252013825 0.5641199969166288 0.13977849200103007 7.57123414339462e-07 1.428953990572369e-07 0.1353401163525886 0.045113314306232256 1.1320183879280164e-10 9.946146518632895 -0.3373257095057871 EALKDEANQK(ub)DK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EALKDEANQKDK 12 2 O94782;C9JC88 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 9812900.0 3522600.0 4357300.0 1933000.0 True False 4825000.414685604 4164780.0783357746 1476465.2113846417 1.0 0.8631667814285878 0.3060031263190778 22.202097635697605 -6.944466101962776 0.6166192488516927 1.0061147520333222 0.13370850873769363 0.9986922563258767 0.010854084705530608 0.08578703001039241 0.04576672845555869 0.010964861309470667 0.04709352487347846 1.136406994311774e-07 6.944466101962776 -0.8724062432956285 down EALKDEANQK(ub)DK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EALKDEANQKDK 12 2 O94782;C9JC88 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 11403000.0 4933100.0 4646800.0 1823100.0 True False 4102091.22338453 4621766.766082414 2204301.7809380037 1.0 1.1266855158499165 0.5373604975852514 21.9679281445308 -6.850455642774991 1.232834248027456 1.0676333638570912 0.5135866903067521 0.9409714522672648 0.06153806836296006 0.15695832446731858 0.4588277390132484 0.0390537290999969 0.09040240289824372 1.411056349151934e-07 6.850455642774991 -0.5540466735503391 EALKDEANQK(ub)DK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EALKDEANQKDK 12 2 O94782;C9JC88 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 11338300.0 3894100.0 2237200.0 5207000.0 True False 5040989.214186774 2112697.853343144 4259379.428331772 1.0 0.4191038233919273 0.8449491255297016 22.26527543685219 -10.350153332818007 6.066482655381838 1.0000420272498658 0.6320264744608378 0.4988879468284664 0.1738506165998144 9.883206316536941e-05 1.0586857592467872e-05 0.1683493022499592 0.05611004523491419 4.4652591304751295e-11 10.350153332818007 -0.368015552789028 EALKDEANQK(ub)DKGNCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EALKDEANQKDKGNCK 16 3 O94782;C9JC88 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 4390700.0 1426700.0 1002500.0 1961500.0 True False 2164408.2057412 823596.0424317486 1573808.6652440098 1.0 0.3805178894845802 0.7271311673414489 21.04554118533752 -10.67123100011946 6.8719665603499775 1.002455930757172 0.5538245284130926 0.6884080582666109 0.1415042781371426 0.005345599812825342 0.00025574398317509153 0.1375571117519932 0.04567030938685462 2.1319106537174736e-11 10.67123100011946 -0.4486314023440795 EALKDEANQK(ub)DKGNCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EALKDEANQKDKGNCK 16 3 O94782;C9JC88 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 7040300.0 1426700.0 1215700.0 4397900.0 True False 1846891.274461434 1148045.2263138122 3597527.3262647013 1.0 0.6216095350001531 1.9478825721962245 20.81666750742997 -6.830446566139458 1.3258442040935734 0.7978728944431018 1.9839160068397144 0.9067785577614964 0.17032049741043317 0.18025985814908643 0.6195514188247202 0.10085682746377009 0.2321056305628719 1.4775882669722016e-07 6.830446566139458 1.1860431123966126 EALLK(ub)IFPDSEQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EALLKIFPDSEQR 13 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 9423800.0 2716400.0 2557600.0 4149800.0 True False 2630169.3688821853 3578863.0177078014 3062842.8886685274 1.0 1.3606967901191884 1.1645040524406332 21.32672427370065 -10.156312601154358 4.300722083240316 0.9999395504345879 1.262600421181494 0.7049025934170201 0.08009534981946069 56064137.84158762 4.272547896106201 34298.17041210245 0.027418768645605725 6.977300036789991e-11 10.156312601154358 0.26266087074690614 EALLQISIPFLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EALLQISIPFLLK 13 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 0 903210000.0 355220000.0 350790000.0 197200000.0 False True 538894710.0605506 288188783.7652205 158223333.56416965 1.0 0.5347775333197081 0.29360713811124917 29.005428184002717 -9.64650752067887 0.1727663712367205 1.583031148659142 2.8037286862484873e-21 0.9996491037804488 0.005491893980205775 1.0964718672508833 0.07150598771366194 0.48030805107177627 0.16720170193504497 2.2567969141997808e-10 9.64650752067887 -1.583031148659142 EALLQISIPFLLKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EALLQISIPFLLKK 14 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 0 20670500.0 5718600.0 6197700.0 8754200.0 False True 8675534.285660338 5091672.012148884 7023928.532897837 1.0 0.5869001083385531 0.8096248947465501 23.048521178604325 -10.064870347083245 5.092934812262842 1.0000052128463262 0.6982625015414728 0.7099051005665913 0.09092701329874622 5.381952438929685e-06 9.884105222756203e-07 0.08804122221959185 0.029346567351663633 8.612508289389166e-11 10.064870347083245 -0.3017427113048533 EALLQISIPFLLKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EALLQISIPFLLKK 14 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 0 16499400.0 5718600.0 4258200.0 6522600.0 False True 7402840.430458496 4021227.4267413677 5335553.727527705 1.0 0.5432006085388918 0.7207441221581548 22.819647500696775 -10.10930220553542 5.170035780410072 1.0000091398898852 0.6319723653479873 0.8513927569385374 0.0724818359198808 7.636143072137197e-06 1.3156594148302813e-06 0.0701819772763168 0.02339341195141764 7.774953395479745e-11 10.10930220553542 -0.36803677454189787 EALLSSAVDHGSDEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EALLSSAVDHGSDEVK 16 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 25680000.0 6498100.0 2188400.0 16993500.0 False True 6291821.372380103 3062239.5323552396 12542392.555927658 1.0 0.48670160055685746 1.993443839805493 22.585046281902386 -6.814792622904115 1.3944604632289688 0.7218010872485204 2.0227499842558436 0.8719321627526059 0.22382672558160394 0.20034007472036489 0.7668607651066572 0.12618281438636775 0.2912823625457434 1.5318187357444347e-07 6.814792622904115 1.300948897007323 EALLSSAVDHGSDEVK(ub)FR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EALLSSAVDHGSDEVKFR 18 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 40863900.0 8576900.0 19130300.0 13156700.0 True False 11244398.958817754 16276133.809325334 11795370.891977957 1.0 1.447488111097458 1.0489996784335134 23.422703211738344 -10.421734592825594 6.366793425747759 0.999948336695649 1.2482438947654857 0.3409976643293845 0.16268222140467958 0.00011932601162770054 1.0837738307505644e-05 0.1575490732664666 0.05250546118536263 3.786739302177207e-11 10.421734592825594 0.24829555806983672 EALLSSAVDHGSDEVK(ub)FR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EALLSSAVDHGSDEVKFR 18 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 53641700.0 17440000.0 19552500.0 16649200.0 True False 16886376.746173352 27359915.214940522 12288275.054706259 1.0 1.6202359823068968 0.7277034759686339 24.00935647126828 -6.719850492829012 1.760159591626446 1.3774157097162856 0.7291373853431898 0.5116472531686491 0.26100310797320003 0.35562147056727483 2.153208888570445 0.11775071056171578 0.295616106923255 1.906116791420942e-07 6.719850492829012 -0.6482783243730957 EALLSSAVDHGSDEVK(ub)FR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EALLSSAVDHGSDEVKFR 18 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 186190000.0 44615000.0 60264000.0 81311000.0 True False 67684216.7933998 49509418.355218925 65239845.21012268 1.0 0.7314765642681829 0.9638856486920969 26.01231611679199 -10.170676883900803 6.8576048871938 1.0000003130282593 0.847681106709307 0.36415770366547007 0.09488061140433461 4.5406274602310255e-07 5.489657482748499e-08 0.09186794587301841 0.030622585653913775 6.750300648461675e-11 10.170676883900803 -0.15231920631895235 EALLSSAVDHGSDEVK(ub)FR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EALLSSAVDHGSDEVKFR 18 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 30331400.0 8576900.0 12583800.0 9170700.0 True False 11748011.712007314 12027806.106938155 7004769.536495151 1.0 1.023816319032511 0.596251494143113 23.485913273261236 -6.893714990161123 1.00012636153664 1.0209696044744643 0.55668166412451 0.9831722129248219 0.02544930988148779 0.11618145593938184 0.20464497822023592 0.01928744815501045 0.04877467993270731 1.2772767587124412e-07 6.893714990161123 -0.46428794034995424 EALLSSAVDHGSDEVK(ub)FR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EALLSSAVDHGSDEVKFR 18 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 43367100.0 17440000.0 18184800.0 7742300.0 True False 14502132.722998954 18086834.87299983 9361179.133649457 1.0 1.2471844809636785 0.6455036174647298 23.789761746702556 -6.79515930876967 1.4756171815623815 1.1372344318172354 0.6381611407553707 0.8175955351005508 0.10546264696094461 0.22775959995034184 0.9795229608639755 0.056239173624836415 0.13119467718499078 1.602657392864044e-07 6.79515930876967 -0.4990732910618647 EALLSSAVDHGSDEVK(ub)FR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EALLSSAVDHGSDEVKFR 18 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 191904000.0 44615000.0 55370000.0 91919000.0 True False 57754996.993128724 52288610.82585824 75190685.16858613 1.0 0.9053521521623344 1.3018905563709369 25.78344243888444 -6.843736421060864 1.26508358138754 0.9496498409242119 1.315914748088321 0.9306628483705233 0.04452607368090139 0.16448383448389525 0.5097589404742353 0.027581075818070237 0.06361410203761655 1.4330573764582982e-07 6.843736421060864 0.3662649071641092 EALPTWDK(ub)QIQSLCFQVNNLLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EALPTWDKQIQSLCFQVNNLLEK 23 1 D6RFN0;Q9BT78;D6RD63 D6RFN0 COPS4 COP9 signalosome complex subunit 4 1 56417000.0 31071000.0 14772000.0 10574000.0 True False 40222022.00097514 13949925.214368371 8649640.498402175 1.0 0.3468230715509571 0.21504738121301992 25.261482273389728 -13.999999999999982 0.22502879294707695 5.030702309251915 0.1478692397431688 0.999503422922337 0.007648156227561375 13.141340544332863 0.15023802544336165 23.601547662892578 0.07058327273383085 1.0000000000000409e-14 13.999999999999982 -4.882833069508747 EALQEK(ub)EEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EALQEKEEQK 10 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 54283000.0 13651000.0 29002000.0 11630000.0 True False 17896593.196472038 24675014.64891054 10426639.162837464 1.0 1.3787548489270425 0.582604691762948 24.093181645760612 -6.777358383100706 1.5463056215308737 1.2152005560741925 0.5768295508830624 0.7578637630542759 0.1599998916332052 0.2547114765408052 1.20278183674146 0.08151480910281822 0.1927583945698493 1.6697121864828812e-07 6.777358383100706 -0.6383710051911301 EALQEK(ub)EEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EALQEKEEQK 10 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 53314000.0 15829000.0 14995000.0 22490000.0 True False 15326517.059356533 20982581.69789199 16599194.314462198 1.0 1.3690378327072388 1.083037604054257 23.869526546981586 -10.41398805350997 6.101085438924201 0.9999399053721424 1.2260377183806448 0.45440219414606353 0.11675910441985392 9.547440358209683e-05 9.170216452918947e-06 0.11308149368982173 0.03768383891134889 3.8548896147698185e-11 10.41398805350997 0.2260978130085024 EALQEK(ub)EEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EALQEKEEQK 10 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 28260000.0 13938000.0 5500500.0 8821500.0 True False 21144965.00429019 4518892.79939734 7077926.658399196 1.0 0.21371011011276128 0.3347334297769292 24.333810836865847 -10.144668544302675 5.575383470807369 1.0000123595513921 0.27422176994475256 0.9795719064052951 0.04940756335948506 7.59067282588417e-06 1.164560997485648e-06 0.04783948072173092 0.015946222505616964 7.166901830301213e-11 10.144668544302675 -0.7257905896066396 EALQEK(ub)EEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EALQEKEEQK 10 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 38884000.0 13651000.0 14843000.0 10390000.0 True False 18698143.604403887 14187187.180762822 7936095.988766904 1.0 0.7587484341184212 0.4244322942785482 24.156391707283504 -6.966540565585921 0.33055245546374495 1.0404688837502887 0.13175860927954608 0.9999414642965309 0.0018055652123198157 0.0774420630230311 0.013037707341297243 0.004868645390396783 0.02914683314030458 1.0800887297116904e-07 6.966540565585921 -0.9087102744707426 down EALQEK(ub)EEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EALQEKEEQK 10 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 38939100.0 15829000.0 17721000.0 5389100.0 True False 13162514.843598071 17625533.45565689 6515935.893616909 1.0 1.3390703573815548 0.4950373063994 23.649931822415862 -6.797715608957675 1.4656508695109414 1.1876262840206724 0.48408840791528013 0.8252722292491621 0.1449583164515903 0.22404016619422895 0.9504287930174633 0.07782316001908426 0.18121123926760532 1.5932517018263877e-07 6.797715608957675 -0.7035378761053923 down EALQEK(ub)EEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EALQEKEEQK 10 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 28318200.0 13938000.0 4909800.0 9470400.0 True False 18043015.75905477 4636565.313938936 7746884.374509925 1.0 0.2569728573014246 0.4293564046033824 24.104937158958297 -10.569212705229976 9.560272444776404 1.0000500049073813 0.3431646309747919 0.9508792270668792 0.07037528849012074 7.501317186188102e-05 3.3800369107180193e-06 0.06814568503832762 0.022713526692231683 2.6964184790089945e-11 10.569212705229976 -0.6568853739325894 EALQEK(ub)EEQKTMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EALQEKEEQKTMK 13 2 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 9040000.0 1738700.0 2941900.0 4359400.0 True False 2637735.015996509 2416894.9598303894 3497762.679207105 1.0 0.9162766332376686 1.326047786451243 21.330868209611364 -6.853481322891689 1.2181643182830573 0.9551505611349567 1.3435629138548495 0.945215281189188 0.04137505975086077 0.15367506963909058 0.43708152249364823 0.026551546644085537 0.06159486548881898 1.4012598457083294e-07 6.853481322891689 0.38841235271989283 EALQEK(ub)EEQKTMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EALQEKEEQKTMK 13 2 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 2455410.0 785160.0 1106400.0 563850.0 True False 652895.3284856566 1100439.6035967942 681748.4280521611 1.0 1.6854763016135894 1.0441925348637846 19.316492193346605 -10.324369992209046 4.113493381776 0.9993934086316731 1.3648344182509902 0.3014558461959317 0.261803001518804 0.0014587811524135502 0.00023960073143201402 0.2539025647039723 0.08449655540014403 4.7383813228669265e-11 10.324369992209046 0.365441009619317 EALQEK(ub)EEQKTMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EALQEKEEQKTMK 13 2 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 9714800.0 1738700.0 2428600.0 5547500.0 True False 2250781.424900884 2293446.275089027 4537911.922156802 1.0 1.0189555723697257 2.016149534536271 21.101994531703813 -6.911018060925247 0.8887869090936258 0.9701081404709344 2.147859747859631 0.991299417640558 0.044270407382226394 0.10374949981415993 0.13515059823513692 0.03642783188804191 0.10127912942388653 1.2273881869288184e-07 6.911018060925247 1.1777516073886967 up EALTYDGALLGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EALTYDGALLGDR 13 0 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 38455700.0 7136700.0 14615000.0 16704000.0 False True 9356282.811901106 12434498.968823817 14975630.316082282 1.0 1.3289999050699117 1.6005961573792338 23.157504039945756 -6.9733230150155165 0.15999677442414287 0.7251077517583697 2.2116945623677653 0.999998063368786 0.0003416871260096673 0.07523841629778594 0.004938905802578591 0.012571168425742366 0.03259212803451824 1.0633518353057206e-07 6.9733230150155165 1.4865868106093956 EALTYDGALLGDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EALTYDGALLGDR 13 0 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 45349700.0 13795000.0 4684700.0 26870000.0 False True 13357085.276001243 6555325.140387764 19831940.917278733 1.0 0.4907751208391068 1.4847506403894046 23.671101887844628 -6.767464953806126 1.584356405013162 0.7069754200381931 1.4897876886824681 0.720700338468298 0.21447621990925544 0.27054714665304114 1.3399102933572307 0.10673235174326191 0.25464223854021756 1.708185559680938e-07 6.767464953806126 0.782812268644275 EALTYDGALLGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EALTYDGALLGDR 13 0 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 41546700.0 7136700.0 18545000.0 15865000.0 False True 9775330.852065725 17725620.579885885 12118013.74993135 1.0 1.813301344796949 1.2396525430513248 23.220714101468648 -9.96575174585972 5.768648157898176 0.999999430941876 1.5264769439244144 0.5289830775722413 0.2341911426402776 1.7139109597972292e-06 3.0809798288982447e-07 0.22675484546544844 0.07558486627278006 1.0820523040840006e-10 9.96575174585972 0.5264775129825383 EALTYDGALLGDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EALTYDGALLGDR 13 0 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 22868400.0 13795000.0 4722900.0 4350500.0 False True 11471153.722119886 4697456.800277754 5260169.435560736 1.0 0.40950168693316547 0.45855626757206847 23.451507163278904 -10.164065987985131 8.174598126157427 1.0000000830557898 0.43402897898892134 0.9943973691498508 0.02002644868525391 3.030397175762037e-08 3.1104704856303885e-09 0.019390528449782323 0.006463508520138841 6.853840792611575e-11 10.164065987985131 -0.5659711040668685 EAMEADLK(ub)AAAEAAAEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAMEADLKAAAEAAAEAK 18 1 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 9404100.0 3501000.0 3614900.0 2288200.0 True False 3389862.6713505085 5058348.421454469 1688851.7754714265 1.0 1.4921986262762799 0.498206546756242 21.692795398032494 -6.772068066749542 1.5664836030799383 1.281572053347006 0.4921693958169221 0.7383920235348059 0.2075580269004968 0.26311785174323643 1.2744970809646472 0.10441959955591713 0.2480989006692469 1.690176010471325e-07 6.772068066749542 -0.789402657530084 down EAMEADLK(ub)AAAEAAAEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAMEADLKAAAEAAAEAK 18 1 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 9534200.0 3501000.0 4215000.0 1818200.0 True False 2911236.620597437 4192292.9583880105 2198377.2135930425 1.0 1.4400385488169898 0.7551351882698895 21.47320067346677 -6.733215034640152 1.711666423907337 1.2638607742048757 0.7553088601642028 0.5740578086036592 0.1849390788759962 0.3302329077212585 1.8968964532909065 0.08557538311740863 0.2115680841469164 1.848353206975798e-07 6.733215034640152 -0.5085519140406729 EAMEADLK(ub)AAAEAAAEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAMEADLKAAAEAAAEAK 18 1 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 16723300.0 2941500.0 8143800.0 5638000.0 True False 3807829.7356334934 7690590.371024459 4611941.850765219 1.0 2.0196781119324405 1.211173337822036 21.86053754034164 -10.17392226746971 4.549919517517894 0.9998976776540573 1.6154257248852197 0.43584003127756055 0.33007069190722205 231439331.79978696 52.93458558830478 260160.89276355287 0.11299197719875952 6.700045199569508e-11 10.17392226746971 0.6155280472311624 EAMEDGEIDGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAMEDGEIDGNK 12 0 P19338;H7BY16 P19338 NCL Nucleolin 0 15244110.0 782710.0 6736300.0 7725100.0 False True 1026140.3897744232 5731270.29789174 6925780.756391722 1.0 5.58526918441603 6.7493501136956695 19.96879669381266 -9.328781692016625 0.4490662229750133 2.0937803864838306e-12 6.826054360847844 0.9979373140913785 0.1127162563770688 0.6938180335576593 0.18268546329342272 1.5083556103997673 0.2601396439844182 4.69049101077483e-10 9.328781692016625 6.826054360845751 EAMEDGEIDGNK ddPTM_RPMI8226_Bortezomib_2h_R1 2 EAMEDGEIDGNK 12 0 P19338;H7BY16 P19338 NCL Nucleolin 0 20291660.0 4733400.0 2270660.0 13287600.0 False True 4583140.807932166 3177346.3793354705 9807178.940544585 1.0 0.6932683311488818 2.1398380175383296 22.12790517966761 -6.85129256325767 1.228896785614736 0.836127944027212 2.1991070231952956 0.9421635895766065 0.14967027513660067 0.15603456622870185 0.45281279498562343 0.09527279293761423 0.2206485775702615 1.408339748192507e-07 6.85129256325767 1.3629790791680836 up EAMEDGEIDGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAMEDGEIDGNK 12 0 P19338;H7BY16 P19338 NCL Nucleolin 0 15455610.0 782710.0 8398100.0 6274800.0 False True 1072099.038942421 8027044.173197075 4792821.473562517 1.0 7.487222618085176 4.470502537051452 20.03200675533555 -9.570047370279188 9.898973879913694 0.9999984626760311 5.978862577568314 0.7841039663455845 1.2315708158903447 0.0 0.0 1.1924633149044515 0.3974877716348171 2.6912412432042627e-10 9.570047370279188 4.978864114892283 EAMEDGEIDGNKVTLDWAKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAMEDGEIDGNKVTLDWAKPK 21 2 P19338;H7BY16 P19338 NCL Nucleolin 0 21606400.0 1994100.0 10257600.0 9354700.0 False True 2614284.410891868 8727206.063811626 8386765.380618725 1.0 3.3382772078858562 3.208053930810674 21.317984671384444 -10.49563705485248 6.5248469452131825 0.9988365746730119 3.273165569348241 0.9975446764717837 0.0531634302445452 0.000899940744522198 6.956452912682639e-05 0.05148579232953438 0.017158423330365248 3.194206176679002e-11 10.49563705485248 2.274328994675229 EAMEDGEIDGNKVTLDWAKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAMEDGEIDGNKVTLDWAKPK 21 2 P19338;H7BY16 P19338 NCL Nucleolin 0 19365800.0 1994100.0 10282300.0 7089400.0 False True 2731372.658526247 9827993.986980898 5415029.730776135 1.0 3.598188609050418 1.9825305470026544 21.381194732907336 -9.917117987234105 6.407366130044387 0.9999997940290724 2.7903595780266426 0.6208200450875299 0.6595896418055378 1.9432077334173017e-06 3.2972593816714963e-07 0.6386450006371069 0.21288164150359085 1.2102692881916622e-10 9.917117987234105 1.7903597839975702 EAMEHPYFYTVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAMEHPYFYTVVK 13 0 P68400;Q8NEV1;E7EU96;A0A2R8YD58;A0A2R8Y5A0;A0A2R8YF43;A0A2R8YFU2;P68400-2;A0A2R8YDP2;A0A087WY74 P68400 CSNK2A1;CSNK2A3 Casein kinase II subunit alpha;Casein kinase II subunit alpha 3 0 15284500.0 4955100.0 4021500.0 6307900.0 False True 6496184.085256659 3421507.875684226 5655219.017649395 1.0 0.5266950306179701 0.8705447603438661 22.631161084717327 -9.852765348670484 5.671556649976 1.0000000938659896 0.6986198954798383 0.5060040010863269 0.14037606434087763 1.6660727660788754e-07 3.3567937945635487e-08 0.13591858237994553 0.04530617994930742 1.403571856132345e-10 9.852765348670484 -0.3013801983861514 EAMEHPYFYTVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAMEHPYFYTVVK 13 0 P68400;Q8NEV1;E7EU96;A0A2R8YD58;A0A2R8Y5A0;A0A2R8YF43;A0A2R8YFU2;P68400-2;A0A2R8YDP2;A0A087WY74 P68400 CSNK2A1;CSNK2A3 Casein kinase II subunit alpha;Casein kinase II subunit alpha 3 0 12404100.0 4955100.0 3236300.0 4212700.0 False True 6787134.376542508 3093309.564987048 3217747.023279917 1.0 0.45576076638147206 0.47409508118787197 22.69437114624022 -10.13562933241502 8.050489221822254 1.0000000588579867 0.46492792380869447 0.9991201998022747 0.007484952676539055 7.916496224240662e-09 8.451099047200016e-10 0.007247275129780326 0.0024157580886155325 7.317633724279846e-11 10.13562933241502 -0.5350721350492922 EAMGIYISTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAMGIYISTLK 11 0 O95433;O95433-2;G3V438;H0YJU2;H0YJG7 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 0 114793000.0 22643000.0 48613000.0 43537000.0 False True 34351086.42503534 39937630.33489742 34931892.86705504 1.0 1.1626307779829217 1.016907949717608 25.033852392227974 -10.773868182576381 2.842818523363324 0.9795858660103445 1.0897693638101698 0.3359838692767195 0.05949109659686994 44523072.606322795 31965823.822718944 6288130.115080063 0.0217715112443513 1.6831848652218105e-11 10.773868182576381 0.11018349779982528 EAMGIYISTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAMGIYISTLK 11 0 O95433;O95433-2;G3V438;H0YJU2;H0YJG7 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 0 91820000.0 22643000.0 43124000.0 26053000.0 False True 29311809.86025807 40724111.49095742 21311621.326354448 1.0 1.389341418530847 0.7270660333823145 24.804978714320423 -6.747409562781245 1.6596693569310341 1.2296501212517525 0.7260240110114876 0.6376577367382226 0.16358643327518863 0.3045818292447585 1.6498922428744105 0.07789391036135418 0.18960495095892324 1.788918013522501e-07 6.747409562781245 -0.5036261102402649 EAMNHPGHLK(ub)LFVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAMNHPGHLKLFVTR 15 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 27698500.0 10363400.0 6986100.0 10349000.0 True False 13586517.759308377 5943801.111604509 9278184.754617792 1.0 0.43747788925034153 0.6828964506568383 23.695672403236163 -10.34896819436326 5.860777494966621 1.0000672535694561 0.5601871699535941 0.8106823849254496 0.100191708142306 8.805822645125548e-05 9.781695114589253e-06 0.09702495769537141 0.03233673475526831 4.477460937436942e-11 10.34896819436326 -0.43988008361586206 EAMNHPGHLK(ub)LFVTR ddPTM_RPMI8226_Bortezomib_2h_R1 2 EAMNHPGHLKLFVTR 15 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 53621800.0 19188300.0 14747800.0 19685700.0 True False 18579177.91964437 20636673.448760994 14529424.611658884 1.0 1.110742011192065 0.7820273143676852 24.147183331836793 -6.815808835700183 1.3897124383008537 1.0599532955590707 0.7754642528753078 0.8745308377120743 0.048370552870983755 0.19897236882566635 0.7561484575601357 0.02735812607153749 0.0631433003222718 1.5282385981532973e-07 6.815808835700183 -0.28448904268376285 EAMNHPGHLK(ub)LFVTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAMNHPGHLKLFVTR 15 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 238123200.0 18028200.0 46385000.0 173710000.0 True False 27350097.43796414 38107234.34234086 139376142.36020246 1.0 1.393312562369337 5.096001675180036 24.70504263701062 -6.927200240750361 0.769425997473918 0.9374610778705323 5.804645516830811 0.9959587732023226 0.11729856914853153 0.09411801242962085 0.08499483093838481 0.10513570336862632 0.34033338388774903 1.1824962148682839e-07 6.927200240750361 4.867184438960279 up EAMNHPGHLK(ub)LFVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EAMNHPGHLKLFVTR 15 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 52756900.0 13371300.0 9700800.0 29684800.0 True False 18315030.955795597 9272186.579744259 22673861.61764655 1.0 0.5062610378395334 1.237991989878218 24.12652480368198 -6.724977174182894 1.741738018352259 0.7012128342727383 1.237155697798991 0.5357161080818369 0.20765115278267157 0.34575049527855467 2.0524626826938546 0.09457442172672538 0.23600896073115984 1.8837480936478455e-07 6.724977174182894 0.5359428635262528 EAMNHPGHLK(ub)LFVTR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 EAMNHPGHLKLFVTR 15 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 58898200.0 19188300.0 16853200.0 22856700.0 True False 15955921.635821132 16762408.466501739 27635930.29255976 1.0 1.0505446723221579 1.7320171735186356 23.92758860727107 -6.921781894579657 0.8114001518890418 0.9859077235873976 1.8465453066600774 0.9946618032966658 0.024388498360462963 0.09713455243508334 0.1002638192375025 0.021213961282767427 0.06467007067713106 1.1973416928699894e-07 6.921781894579657 0.8606375830726798 EAMNHPGHLK(ub)LFVTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAMNHPGHLKLFVTR 15 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 216863200.0 18028200.0 41429000.0 157406000.0 True False 23337860.288950425 39123439.73098213 128759723.12194946 1.0 1.6763936044944776 5.51720344229296 24.47616895910307 -6.937011796309363 0.6867981752263792 0.9538569187263227 6.4678316032087615 0.9977457629605877 0.09444776588807294 0.08915664554354095 0.06101771797665287 0.08997601637124945 0.33515382728618165 1.1560808402908041e-07 6.937011796309363 5.513974684482439 EANAFEEQLLK(ub)QK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EANAFEEQLLKQK 13 1 O43683-2;O43683-3;O43683;A0A590UK50 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 7933000.0 1436400.0 3230800.0 3265800.0 True False 1883134.3101173888 2748777.23355976 2927886.343765656 1.0 1.4596819880512981 1.5547942215460673 20.844704469770257 -11.869041667890531 0.262076436833279 4.273593020493944e-15 1.5925325613530894 0.9993730679838408 0.006065514131177317 4.832487694183363 0.14903835895552012 2.687761973474022 0.04104764096795025 1.3519428463515715e-12 11.869041667890531 1.5925325613530852 EANAFEEQLLK(ub)QK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EANAFEEQLLKQK 13 1 O43683-2;O43683-3;O43683;A0A590UK50 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 7582000.0 2013500.0 2719800.0 2848700.0 True False 1949582.5446341767 3805830.3235696326 2102540.0108318566 1.0 1.9521257686905304 1.078456522201978 20.894733808549745 -10.233686467709285 4.2570058098409485 0.9997187450132101 1.5152911454658897 0.31685616010966033 0.35667397637513615 251562160.85189244 345.3755248605233 694731.266494493 0.12209898907529196 5.838664656654451e-11 10.233686467709285 0.5155724004526796 EANAFEEQLLK(ub)QK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EANAFEEQLLKQK 13 1 O43683-2;O43683-3;O43683;A0A590UK50 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 4404100.0 1436400.0 1258500.0 1709200.0 True False 1967475.8972504423 1202895.30869703 1305522.1620789599 1.0 0.6113901117559215 0.6635517944100021 20.907914531293148 -10.117859363683326 5.144413598566534 1.0000105013836265 0.6374709530826984 0.9847107028836489 0.021294917773131184 2.5649237167472417e-06 4.3982992630607793e-07 0.020619312436289842 0.006872905157578682 7.623258318123971e-11 10.117859363683326 -0.36253954830092805 EANAGNLK(ub)PLFEFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EANAGNLKPLFEFVR 15 1 Q0PNE2;C9IYN7;Q0PNE2-2;C9JLH5;C9JA82;C9J2D6;C9J9N8;C9JEX8 Q0PNE2 ELP6 Elongator complex protein 6 1 17185600.0 1660300.0 2727300.0 12798000.0 True False 1607594.6853022727 3816325.112681614 9445819.868229745 1.0 2.373934890164207 5.875747136134422 20.616472282300794 -6.955046655750983 0.5003862780016837 0.9301037855808691 7.470712814762989 0.9995401043079968 0.044021156858063994 0.08152038594661118 0.028049205707448815 0.0515880309072454 0.28887150563390585 1.1090556643025228e-07 6.955046655750983 6.54060902918212 EANAGNLK(ub)PLFEFVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EANAGNLKPLFEFVR 15 1 Q0PNE2;C9IYN7;Q0PNE2-2;C9JLH5;C9JA82;C9J2D6;C9J9N8;C9JEX8 Q0PNE2 ELP6 Elongator complex protein 6 1 19066800.0 1660300.0 3661500.0 13745000.0 True False 1380613.0137611914 3641774.772749156 16619015.950300513 1.0 2.637795483926305 12.03741800537247 20.39687755773507 -6.936782500609171 0.6888437862532297 0.8863501576995513 14.34901759085192 0.9977114009965901 0.23265398599324918 0.08926560085260439 0.061526294989577485 0.22128919184541113 0.8211285321087901 1.1566913807599904e-07 6.936782500609171 13.462667433152369 EANFTVSSMHGDMPQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EANFTVSSMHGDMPQK 16 0 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 21322000.0 5151500.0 7083600.0 9086900.0 False True 6753666.387196964 6026754.491656542 8146674.755699724 1.0 0.8923678112205186 1.2062595764492468 22.687239485207346 -6.814151159153998 1.3970387313471517 0.9416218518274034 1.2122865173776916 0.8703776428858323 0.046889464277917126 0.20119876343301407 0.7731197077652182 0.0263852539679598 0.060927202045371325 1.534082941844217e-07 6.814151159153998 0.2706646655502881 EANFTVSSMHGDMPQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EANFTVSSMHGDMPQK 16 0 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 17800860.0 5151500.0 5858460.0 6790900.0 False True 7056148.7640529405 5599613.865863486 5187029.282975667 1.0 0.793579338121431 0.7351076991744601 22.750449546730238 -13.999999999999998 0.1769251177921807 2.0611972112649437 0.6871558073224764 0.9995021683725207 0.002535216839159993 12.166472049181744 0.13330859889864488 4.4354870599659515 0.044825140664104424 1.0000000000000041e-14 13.999999999999998 -1.3740414039424673 EANFTVSSMHGDMPQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EANFTVSSMHGDMPQK 16 0 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 5811100.0 2567200.0 2076000.0 1167900.0 False True 2134740.546243286 2064816.1759462645 1412102.490240523 1.0 0.9672445579299674 0.6614867051293606 21.025629306432712 -6.927344493626999 0.7682770109004956 1.0051362526814236 0.6027602232847176 0.9959900825698026 0.00965333614904792 0.09404039383553985 0.08460861154723433 0.008659513980812437 0.02808063458733202 1.182103508624839e-07 6.927344493626999 -0.402376029396706 EANFTVSSMHGDMPQK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EANFTVSSMHGDMPQKER 18 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 19183800.0 6712000.0 7564400.0 4907400.0 True False 8799496.999100454 6435821.005800256 4399629.323104786 1.0 0.7313851014959344 0.49998645644797046 23.06898962743278 -6.972864318234715 0.176852060215576 1.1865226455713582 0.03861089624205015 0.9999969668951155 0.0003557896463684913 0.07538374602675782 0.005557758045047219 0.00916406930692934 0.02622151308769646 1.0644755284584049e-07 6.972864318234715 -1.147911749329308 down EANFTVSSMHGDMPQK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EANFTVSSMHGDMPQKER 18 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 19655500.0 7896400.0 4000300.0 7758800.0 True False 7645733.104270822 5597640.65128892 5726537.5209893 1.0 0.7321260858768585 0.7489847530501057 22.866223409064425 -10.113219641366397 4.912264507166307 1.000011427333613 0.7405554194622089 0.9968432100034919 0.006882522057385982 8.613821120601053e-07 1.554864975783869e-07 0.006664266754062262 0.0022213244417177854 7.705136886532108e-11 10.113219641366397 -0.259456007871404 EANFTVSSMHGDMPQK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EANFTVSSMHGDMPQKER 18 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 90896400.0 9933600.0 18889800.0 62073000.0 True False 15069997.443436427 15518767.603318946 49804244.34243765 1.0 1.0297790468490078 3.304860835535798 23.845175836399967 -6.9097524388956915 0.8973997387845036 0.9290057364803117 3.5973443810397003 0.990828234825678 0.10338982177494463 0.10458253813904098 0.13964975104607513 0.08454307458353447 0.23298455133902274 1.2309702614618e-07 6.9097524388956915 2.6683386445593884 up EANFTVSSMHGDMPQK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EANFTVSSMHGDMPQKER 18 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 21497800.0 6712000.0 6397200.0 8388600.0 True False 9193607.784979772 6114550.551288549 6407385.448640036 1.0 0.6650871664634541 0.696939177578167 23.132199688955673 -9.988421929777122 5.916156185225238 1.0000003304600893 0.6810131723491537 0.9925774357689101 0.013003529085641827 5.6687884073759e-08 9.672263064003327e-09 0.012590626030335348 0.004196870965851741 1.0270180352585436e-10 9.988421929777122 -0.3189871581109356 EANFTVSSMHGDMPQK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EANFTVSSMHGDMPQKER 18 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 22819800.0 7896400.0 8317200.0 6606200.0 True False 6566206.469833075 8272393.592765061 7987525.876382341 1.0 1.2598436602276628 1.2164597493361182 22.6466286844987 -10.125248193244648 4.688563797146609 0.9999811408048795 1.2381517047849704 0.9757152076957843 0.017711407465664488 3.491837183923624e-06 6.514663718141356e-07 0.017150353850800132 0.005716332177873881 7.494657776743888e-11 10.125248193244648 0.23817056398009084 EANFTVSSMHGDMPQK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 3 EANFTVSSMHGDMPQKER 18 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 250759400.0 12420500.0 22088800.0 216250100.0 True False 16078582.09465776 20859538.862384256 176894800.7134026 1.0 1.2973494018054619 11.001890569204939 23.93863685087764 -6.913438506059035 0.8720083944740289 0.7312115967065594 12.352774445431951 0.992155416874693 0.41153326204247265 0.10218748597682663 0.12676429054296778 0.34276452708583083 0.9702983325267017 1.2205666346806542e-07 6.913438506059035 11.621562848725391 up EANLAASFGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EANLAASFGK 10 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 23508900.0 6828600.0 5692300.0 10988000.0 False True 8952360.728256468 4843031.028411611 9851067.164338628 1.0 0.5409780923064774 1.1003876478352308 23.093836739059125 -6.688641695423363 1.8710591785347686 0.7118570323074707 1.0984318295597877 0.36411963068655306 0.19418796696430754 0.41961627082425096 2.8470519112953188 0.08305599688557551 0.21666923370924482 2.0481337050149238e-07 6.688641695423363 0.386574797252317 EANLAASFGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EANLAASFGK 10 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 13300700.0 3154600.0 2025300.0 8120800.0 False True 3054458.949740737 2834012.8517999733 5993718.8612220725 1.0 0.9278281025975237 1.962284961050408 21.54248542083959 -6.890164495031517 1.0213853570543372 0.9446365504616817 2.051553044740382 0.9810042018395141 0.06499259005208181 0.11901073328990307 0.2210572697218152 0.0484726767433385 0.12091771604090253 1.2877617017837764e-07 6.890164495031517 1.1069164942787002 EANLAASFGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EANLAASFGK 10 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 21858000.0 6828600.0 8009400.0 7020000.0 False True 9353317.9559763 7655518.224456085 5362020.581438275 1.0 0.8184815549400407 0.5732747038725667 23.157046800582016 -6.966939121754392 0.32304795283657756 1.0324023032223333 0.3514093276170984 0.9999477151627417 0.0012643359910857934 0.07730898136126689 0.012571845774703513 0.003672058040807146 0.021511674146392858 1.0790979767132195e-07 6.966939121754392 -0.6809929756052349 EANLAASFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EANLAASFGK 10 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 6774500.0 3154600.0 2159900.0 1460000.0 False True 2623189.672475487 2148264.189993418 1765279.2497227166 1.0 0.8189511465886928 0.6729514332285527 21.322890696273866 -6.973567983676851 0.15020703162348836 1.1692284809711744 0.3188334607807176 0.9999985340618834 0.00016186318098211497 0.07516107117329597 0.0045921450531854965 0.007435782762317221 0.018197931488354264 1.0627522089352862e-07 6.973567983676851 -0.8503950201904568 EANLLNAVIVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EANLLNAVIVQR 12 0 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 0 16807100.0 4882500.0 6391200.0 5533400.0 False True 6401004.782197259 5437657.872702477 4960856.848120801 1.0 0.8495006733670809 0.7750122077580918 22.609866955767114 -13.999999999997177 0.09178431608288247 1.7648615102172045 0.5940286479816065 0.9998339755966815 0.00120579276194973 12.147849579358 0.08845744329065637 1.802127555557042 0.16235523225048623 1.0000000000064994e-14 13.999999999997177 -1.170832862235598 EANLLNAVIVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EANLLNAVIVQR 12 0 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 0 16306300.0 6238600.0 2466300.0 7601400.0 False True 6040559.057836986 3451106.451584594 5610365.302888075 1.0 0.5713223591626256 0.9287824602276208 22.52625064745805 -10.027311103572883 7.074546570879438 1.000000032848539 0.7500524096951232 0.3946367628167925 0.14593247516882443 7.5591996382572e-08 1.0416629977950881e-08 0.14129852834397655 0.04709950383330697 9.390503879169908e-11 10.027311103572883 -0.2499476231534158 EANLLNAVIVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EANLLNAVIVQR 12 0 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 0 26098300.0 3436400.0 18593000.0 4068900.0 False True 5213270.03449152 15274933.882227963 3264680.13153778 1.0 2.930010105206034 0.6262250199852161 22.313757159227798 -6.6844648860663085 1.8859601165582234 2.21619831077622 0.6346469184525132 0.34472015076561346 0.8171953567032207 0.42866932049660034 2.951563355755897 0.34720042131429435 0.9105344349757857 2.0679265728559547e-07 6.6844648860663085 -1.581551392323707 EANLLNAVIVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EANLLNAVIVQR 12 0 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 0 23565300.0 4882500.0 10096000.0 8586800.0 False True 6687692.194601279 9649925.336992621 6558774.690697167 1.0 1.442938020500202 0.980723170242766 22.673077017290005 -8.873215039065832 18.14149326269076 0.9999945881360645 1.211830595371484 0.21877766049105285 0.18869842247047738 0.0 0.0 0.18270646190925385 0.060902153969751266 1.3390135164079755e-09 8.873215039065832 0.21183600723541962 EANLLNAVIVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EANLLNAVIVQR 12 0 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 0 14023300.0 3436400.0 6946000.0 3640900.0 False True 4448487.541570944 6559448.993975274 2978293.5587887694 1.0 1.474534644118361 0.669507002314097 22.084883481320247 -6.74700119555412 1.6611331575408121 1.2800425646451523 0.6682869055444896 0.6358475998965808 0.19938009877102095 0.3053258793780232 1.6566996838264585 0.09485790633744899 0.23100196803723919 1.7906009247457271e-07 6.74700119555412 -0.6117556591006628 EANNFLWPFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EANNFLWPFK 10 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 45899000.0 15936000.0 14140000.0 15823000.0 False True 20892250.324443508 12030367.117288303 14185787.744933555 1.0 0.5758291677758148 0.6789975959811506 24.31646455906104 -9.890492418141475 6.566193276912242 1.0000000193190612 0.6274133818784735 0.9456226237977639 0.042118334444730864 1.1950296353894997e-08 1.9897649754918626e-09 0.0407809040954695 0.013593633989527738 1.2867897174468682e-10 9.890492418141475 -0.37258663744058773 EANNFLWPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EANNFLWPFK 10 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 42367000.0 16585000.0 8828000.0 16954000.0 False True 16058518.25317 12353066.437411826 12513238.790902251 1.0 0.7692531927703412 0.7792274849787028 23.936835443279374 -9.98707133101111 5.536393568564358 1.0000005567683663 0.7742403388764671 0.9985381652186688 0.004071987743569723 2.798397238705161e-08 5.114868151266364e-09 0.00394269493121371 0.001314228392933797 1.0302168978258746e-10 9.98707133101111 -0.22576021789189915 EANNFLWPFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EANNFLWPFK 10 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 70649000.0 15936000.0 23148000.0 31565000.0 False True 21827969.85420704 22125244.819800425 24109997.101581026 1.0 1.0136189928600297 1.1045460142475942 24.37967462058393 -6.93361885674185 0.7164682001605164 0.9987855888005756 1.1250579855880443 0.9972028421912819 0.002454411095526841 0.09080190046355567 0.06879169105207644 0.002286327315259103 0.008069884754652791 1.1651481320655346e-07 6.93361885674185 0.1262723967874687 EANNFLWPFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EANNFLWPFK 10 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 33630000.0 16585000.0 10633000.0 6412000.0 False True 13791162.340076689 10575717.91851475 7752719.554261692 1.0 0.766847467800596 0.5621512794271538 23.71724071871365 -6.9726548530335775 0.18403702930422564 1.1500212001729977 0.1734196956229768 0.9999963675142036 0.0003408738265930613 0.07545028743491781 0.005830586986360219 0.007607990807782703 0.022696369486241416 1.0649890610250066e-07 6.9726548530335775 -0.9766015045500209 EANQAINPK(ub)LLQLVEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EANQAINPKLLQLVEDR 17 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 27679600.0 4252000.0 16796000.0 6631600.0 True False 5574413.1764265755 14290102.270295216 5945425.646799047 1.0 2.5635168793598018 1.066556327747902 22.410388508524065 -6.636017067231916 2.058924388893136 2.025540596171942 1.0727402689765386 0.13943812445914827 0.6696561322671587 0.5435249992367075 4.398588768493032 0.2653228660700081 0.7415278800164699 2.3119739306960072e-07 6.636017067231916 -0.9528003271954033 EANQAINPK(ub)LLQLVEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EANQAINPKLLQLVEDR 17 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 38393000.0 12562000.0 15011000.0 10820000.0 True False 12163226.186091151 21004970.581330884 7985917.406957799 1.0 1.7269242765007866 0.6565624353915104 23.53602260560413 -6.72383651780014 1.7457047437470241 1.440432630100281 0.6578813661968242 0.5304880682974102 0.3057568834978932 0.3479074784369478 2.0740763648815164 0.13896750157522053 0.34727053704599087 1.8887021826265358e-07 6.72383651780014 -0.7825512639034568 EANQAINPK(ub)LLQLVEDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EANQAINPKLLQLVEDR 17 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 85162300.0 0.0 8796300.0 76366000.0 True False 0.0 7226531.539194402 61272226.627593145 0.0 EANQAINPK(ub)LLQLVEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EANQAINPKLLQLVEDR 17 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 21003800.0 4252000.0 8888400.0 7863400.0 True False 5824079.3059794465 8495681.097991802 6006226.871806511 1.0 1.4587165887781584 1.031274911665447 22.473598570046956 -10.414129921103635 3.499252637875212 0.9978184746291333 1.2449957500502795 0.3046033601021625 0.1745023343162586 126236728.70827375 211020981.82551846 2832029.21502931 0.06386132200697991 3.8536305736747764e-11 10.414129921103635 0.2471772754211462 EANQAINPK(ub)LLQLVEDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EANQAINPKLLQLVEDR 17 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 33396700.0 12562000.0 13143000.0 7691700.0 True False 10445859.590958307 13072196.050318763 9299998.907597415 1.0 1.2514236800228247 0.8903047974766268 23.316427881038408 -6.719448547894318 1.7610286659703163 1.1530480792636155 0.8908738561782468 0.5100711309880965 0.10580679972263562 0.35637231054335533 2.1595499137006864 0.04770910736444227 0.11985771119985737 1.907881742791739e-07 6.719448547894318 -0.26217422308536875 EAPAGALAAVLK(ub)HSSTLPPESTQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAPAGALAAVLKHSSTLPPESTQVR 25 1 P49366;P49366-2;Q5J8M5;M0R253;M0QX43;B4E3M2;A0A3B3IU31 P49366 DHPS Deoxyhypusine synthase 1 36325000.0 23775100.0 11272600.0 1277300.0 True False 19770049.065514483 11211872.266364086 1544377.5244320745 1.0 0.5671140334153904 0.07811703042892193 24.236813115778737 -7.736251092690231 0.5059853792561768 1.0185500174878557 1.0625867880668273e-23 0.9951201977272807 0.02630687454571584 0.11485104948448384 0.09885527314138463 0.0315426814084224 0.07640459571921622 1.835476833034559e-08 7.736251092690231 -1.0185500174878557 down EAPATGPSPQHPQK(ub)MDGELGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAPATGPSPQHPQKMDGELGR 21 1 Q9H0F6;H0YCU2 Q9H0F6 SHARPIN Sharpin 1 22769700.0 4065000.0 3597500.0 15107200.0 True False 3935958.8000685032 5034000.510714662 11150171.113714688 1.0 1.2789769320316686 2.8328983305213016 21.90828368856638 -6.937428140526954 0.6830680184171256 0.9815397158038057 3.2220333593035373 0.9978073031559863 0.037759026886759486 0.08895971409649583 0.0601004504364115 0.03607535768941093 0.13532791817505194 1.1549730736715846e-07 6.937428140526954 2.2404936434997316 up EAPATGPSPQHPQK(ub)MDGELGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAPATGPSPQHPQKMDGELGR 21 1 Q9H0F6;H0YCU2 Q9H0F6 SHARPIN Sharpin 1 74918900.0 5679800.0 35405400.0 33833700.0 True False 8616671.849000394 29087029.74634719 27146454.36516247 1.0 3.375668733366181 3.1504570257380387 23.0386993117124 -9.819015871044835 6.267059879349782 0.9999999111016898 3.2630628795531385 0.9926271381782714 0.09194229463531546 1.1537481677778335e-07 2.1590238699616243e-08 0.08902274663497492 0.02967424799401501 1.51699492872948e-10 9.819015871044835 2.2630629684514485 EAPATGPSPQHPQK(ub)MDGELGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAPATGPSPQHPQKMDGELGR 21 1 Q9H0F6;H0YCU2 Q9H0F6 SHARPIN Sharpin 1 13195000.0 4333100.0 3023000.0 5838900.0 True False 5935164.167624532 2889433.864275821 4459872.075920213 1.0 0.4868330146682829 0.7514319654792658 22.500856504927192 -10.409599336788464 5.005586655133248 1.000422155299568 0.6191324900737354 0.734222893472306 0.10802206932725068 0.0005094623445295205 6.009005142310098e-05 0.10470534236889825 0.03486397296058941 3.8940422853884873e-11 10.409599336788464 -0.38128966522583263 EAPATGPSPQHPQK(ub)MDGELGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAPATGPSPQHPQKMDGELGR 21 1 Q9H0F6;H0YCU2 Q9H0F6 SHARPIN Sharpin 1 11066100.0 4065000.0 5878200.0 1122900.0 True False 3380227.610033874 5846532.969868656 1357693.1982970142 1.0 1.7296270087001824 0.4016573304906555 21.688688964000658 -6.757527884905681 1.6217127519401104 1.425105548505261 0.3973786211143835 0.6808250261680034 0.30678436896398475 0.2870876496491914 1.487490851195769 0.14929880583645816 0.35967885894532187 1.7477210422472102e-07 6.757527884905681 -1.0277269273908776 EAPATGPSPQHPQK(ub)MDGELGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAPATGPSPQHPQKMDGELGR 21 1 Q9H0F6;H0YCU2 Q9H0F6 SHARPIN Sharpin 1 66040500.0 5679800.0 22913800.0 37446900.0 True False 7352613.065596165 21638626.887150995 30631948.437641013 1.0 2.942984581685789 4.166130893106819 22.80982563380485 -8.395678081921796 0.23859819306278424 4.169473060296271e-18 5.241517312726149 0.9994704388107392 0.02999997783788352 0.1255623409937368 0.05977691236009309 0.5247379753730138 0.4819596115996908 4.020887461912531e-09 8.395678081921796 5.241517312726149 EAPCVLIYIPDGHTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAPCVLIYIPDGHTK 15 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 67114000.0 23317000.0 18637600.0 25159400.0 False True 30568812.80214918 15856942.728795782 22556146.634006307 1.0 0.5187294263413769 0.7378810155303273 24.865557187724914 -10.333048416891945 5.820766239957834 1.0000487547801333 0.6283052209358513 0.793196312430843 0.08946826163883179 5.6614130673379713e-05 6.486907059617771e-06 0.08663859676339629 0.028875757278443045 4.644634920820198e-11 10.333048416891945 -0.37174353384428205 EAPCVLIYIPDGHTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAPCVLIYIPDGHTK 15 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 46121500.0 7843500.0 26753000.0 11525000.0 False True 11899162.936658783 21978718.12785692 9247078.698413048 1.0 1.8470810295525224 0.7771201006017634 23.50435675290388 -6.695680912865238 1.8460255151813318 1.5282046524134585 0.7805218217406708 0.3972265372107803 0.35785251962666553 0.40457253852165903 2.67720678008734 0.1548221051149319 0.40033468564604524 2.015204327634144e-07 6.695680912865238 -0.7476828306727877 EAPCVLIYIPDGHTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAPCVLIYIPDGHTK 15 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 68083100.0 23317000.0 21832100.0 22934000.0 False True 31937925.01823203 20867485.632899813 17517461.54055632 1.0 0.6533763737308368 0.5484846473450086 24.928767249247805 -13.999999999999998 0.16747020001591031 2.7367598949210943 0.45342151328724634 0.9995187345691743 0.004232565241653352 12.067928539967406 0.1295368840833015 6.8075109114366334 0.08752763267425633 1.0000000000000041e-14 13.999999999999998 -2.2833383816338477 EAPCVLIYIPDGHTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAPCVLIYIPDGHTK 15 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 26675600.0 7843500.0 11079000.0 7753100.0 False True 10153565.368499503 10462443.910776291 6342115.353523918 1.0 1.0304206976630155 0.6246195423333507 23.27548307499633 -6.888837652843198 1.0292647379732451 1.0224157306538975 0.5905053852921431 0.9801427191573474 0.02600526544570445 0.12009005316333901 0.2274122682914312 0.01928046645801971 0.04786835917148176 1.2917020450335225e-07 6.888837652843198 -0.4319103453617543 EAPNPIHLTVDTSLQNGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAPNPIHLTVDTSLQNGR 18 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 26377500.0 9829900.0 9783700.0 6763900.0 False True 12887094.092887018 8324010.096563895 6064036.511910268 1.0 0.6459183145995885 0.47055111634959584 23.61942365169619 -13.99999999917924 0.09166668044478621 2.80036377334907 0.043631404335419365 0.9998345387092858 0.0028326317531024697 12.148911451748805 0.08837305600586591 4.238482107773572 0.3830167281792834 1.0000000018898706e-14 13.99999999917924 -2.7567323690136507 EAPNPIHLTVDTSLQNGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAPNPIHLTVDTSLQNGR 18 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 24316000.0 6622400.0 5800600.0 11893000.0 False True 6412175.536918492 8116809.829729387 8777866.517647786 1.0 1.265843360493854 1.3689373391462358 22.61238248994692 -13.13852800616992 0.14037411205973424 1.189557608719467e-14 1.5014817188688692 0.9996144643702538 0.003051798114224775 8.772587605300181 0.10977246385460322 2.520295143308658 0.11279134240859805 7.26895522689595e-14 13.13852800616992 1.5014817188688572 EAPNPIHLTVDTSLQNGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAPNPIHLTVDTSLQNGR 18 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 95607000.0 15876000.0 52450000.0 27281000.0 False True 24085052.69106839 43089887.70627953 21888898.392312936 1.0 1.7890717640928735 0.9088167118866273 24.521634744335717 -6.670348395652205 1.935596692343157 1.5034813725093352 0.9123224883819151 0.2808939323340005 0.33514799093387865 0.46027384992658144 3.3247179763971237 0.13936130512979636 0.3722428348794708 2.1362476813264897e-07 6.670348395652205 -0.5911588841274201 EAPNPIHLTVDTSLQNGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAPNPIHLTVDTSLQNGR 18 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 29368600.0 9829900.0 8672700.0 10866000.0 False True 13464279.673059117 8289511.437216313 8299674.592294611 1.0 0.6156669081824646 0.6164217317099819 23.682633713219083 -9.960923247547715 5.938361233822837 1.0000002593390918 0.6160443199461234 0.9999971003799742 0.00030815541506610454 1.0578519513483842e-09 1.8492962037952418e-10 0.00029837039756179143 9.945673249758565e-05 1.0941497172290244e-10 9.960923247547715 -0.38395593939296835 EAPNPIHLTVDTSLQNGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAPNPIHLTVDTSLQNGR 18 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 59222000.0 15876000.0 25823000.0 17523000.0 False True 20551794.96274599 24385927.349758632 14333993.80116335 1.0 1.1865594900086698 0.6974570263641896 24.292761066428167 -6.803332468952342 1.4422981016202936 1.1025022749106845 0.6901390673738309 0.8417180330793581 0.08018120133162113 0.2160364202935764 0.8868584460820651 0.04372790138950334 0.10149429170294104 1.5727783817853285e-07 6.803332468952342 -0.4123632075368536 EAPPMEKPEVVK(ub)THLR ddPTM_RPMI8226_Bortezomib_2h_R1 2 EAPPMEKPEVVKTHLR 16 2 P62841;K7EJ78;K7EQJ5;K7EM56;S4R417;K7ELC2;S4R456;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 1 43124200.0 10029400.0 13848600.0 19246200.0 True False 9711022.186816009 19378418.199494928 14205042.84637628 1.0 1.9955075610684612 1.462775243749468 23.21119173172802 -10.185400971208734 4.774771172442334 0.9999059653744637 1.7291414024121456 0.7140996663720267 0.21748705783127076 0.0002177361455968187 3.7146974438673645e-05 0.21060786410515137 0.07019364608146013 6.525278148757004e-11 10.185400971208734 0.7292354370376819 EAPPMEKPEVVK(ub)THLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAPPMEKPEVVKTHLR 16 2 P62841;K7EJ78;K7EQJ5;K7EM56;S4R417;K7ELC2;S4R456;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 1 11972000.0 3939500.0 3127800.0 4904700.0 True False 5976509.5160282105 2569619.6523870584 3935283.8951936257 1.0 0.42995324369444693 0.6584585676036678 22.510871716934673 -10.252873832586744 5.5809959452838305 1.0000308361807624 0.5442059056490478 0.8413951302119309 0.09328690784788043 3.579516134041044e-05 4.791877727583967e-06 0.09033075651592504 0.030108220042828357 5.586324601548722e-11 10.252873832586744 -0.4558249305317146 EAPPMEKPEVVK(ub)THLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAPPMEKPEVVKTHLR 16 2 P62841;K7EJ78;K7EQJ5;K7EM56;S4R417;K7ELC2;S4R456;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 1 29046900.0 12312600.0 8005300.0 8729000.0 True False 16864900.95550389 7651599.37601297 6667389.979398092 1.0 0.4536996331138166 0.39534118800870743 24.00752050990686 -13.999999999999998 0.3159097963180705 6.467364563725034 0.3832190625483372 0.999684903781694 0.004834074388035876 17.70148720753845 0.1790698593473831 63.8238512557677 0.01974601863024825 1.0000000000000041e-14 13.999999999999998 -6.084145501176696 EAPPMEKPEVVK(ub)THLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAPPMEKPEVVKTHLR 16 2 P62841;K7EJ78;K7EQJ5;K7EM56;S4R417;K7ELC2;S4R456;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 1 35459000.0 7604800.0 13993000.0 13861200.0 True False 6323728.149762759 13917616.93160698 16759512.833052423 1.0 2.2008562990060088 2.650258271093006 22.592343918453242 -9.887646404219302 0.2498698482594512 3.219740342890347e-14 2.9072311852026425 0.9990968099216108 0.020935258043802803 1.3248602809044647 0.11026252974686815 1.1518881537017287 0.2006750079497559 1.2952499845556384e-10 9.887646404219302 2.90723118520261 EAPPMEKPEVVK(ub)THLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAPPMEKPEVVKTHLR 16 2 P62841;K7EJ78;K7EQJ5;K7EM56;S4R417;K7ELC2;S4R456;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 1 124803500.0 21464500.0 37959000.0 65380000.0 True False 27786218.378550064 35846548.281357266 53481510.855450474 1.0 1.290083731186302 1.924749533269926 24.727866165617606 -6.958251984947435 0.45941193635181893 0.9813915819608182 2.2590008211767287 0.9996997554065027 0.006691298303819304 0.08033163680630559 0.023484473318338764 0.008610894959711525 0.052433132458498656 1.1009003633277816e-07 6.958251984947435 1.2776092392159106 EAPTAYSLLIMHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAPTAYSLLIMHR 13 0 Q06203 Q06203 PPAT Amidophosphoribosyltransferase 0 10390400.0 3420500.0 2922400.0 4047500.0 False True 4484308.62416912 2486389.3114259783 3628703.526361532 1.0 0.5544643600186354 0.809200220253324 22.096454141677185 -10.18774933735284 5.499466109785055 1.0000108570318054 0.6818322901359457 0.6753284268774932 0.10399547946077402 1.384402840010542e-05 2.044763110747504e-06 0.10069662416975535 0.03356439666935191 6.490089152897922e-11 10.18774933735284 -0.31817856689585966 EAPTAYSLLIMHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAPTAYSLLIMHR 13 0 Q06203 Q06203 PPAT Amidophosphoribosyltransferase 0 8562800.0 3204100.0 1199300.0 4159400.0 False True 3102387.599335665 1678186.7442668767 3069928.3606746993 1.0 0.5409339389527724 0.9895373361252745 21.56494751124514 -10.843077693908304 10.408246436739656 1.0054619301000156 0.7652356375390235 0.26748276759969236 0.18314156999195533 0.02335250176306533 0.00035207871082327353 0.17839932806822065 0.0591086875480936 1.4352326518066293e-11 10.843077693908304 -0.24022629256099215 EAPTAYSLLIMHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAPTAYSLLIMHR 13 0 Q06203 Q06203 PPAT Amidophosphoribosyltransferase 0 5874500.0 3204100.0 0.0 2670400.0 False True 2664351.1156973 0.0 3228768.293465442 1.0 0.0 1.2118403893701621 21.345352786679417 -10.756865846378197 6.240524916086305 1.0119756563999085 0.6059201987462334 0.12357509691968271 0.49473176727543083 0.0824938537858978 0.003214000830441266 0.4793854882375178 0.15967399129145893 1.7503872999869494e-11 10.756865846378197 -0.4060554576536751 EAPTAYSLLIMHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAPTAYSLLIMHR 13 0 Q06203 Q06203 PPAT Amidophosphoribosyltransferase 0 10244600.0 1941500.0 3792900.0 4510200.0 False True 2513310.022686531 3581821.7807729435 3689389.8785600043 1.0 1.4251412473755456 1.4679406222302558 21.261157211336812 -11.883210407102055 0.3683132531809436 9.40090766166516e-22 1.4729991195779861 0.9996421969459458 0.003995467322902569 5.054382577991237 0.19039318718503287 3.925173727034855 0.012016217224644517 1.3085478038268607e-12 11.883210407102055 1.4729991195779861 EAQDDLVK(ub)TK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAQDDLVKTK 10 1 P15311;E7EQR4 P15311 EZR Ezrin 1 9632600.0 3280400.0 4587700.0 1764500.0 True False 4300636.167438792 3903233.042714533 1581926.4662791665 1.0 0.9075943397088322 0.3678354561253829 22.036118654190947 -6.936405627450838 0.6921975714019348 1.0065969964811583 0.23648316416332898 0.9976541358343111 0.013502906038822466 0.08944545359632816 0.0623685486871456 0.012810287054282945 0.04723832138784671 1.1576955729642031e-07 6.936405627450838 -0.7701138323178294 down EAQDDLVK(ub)TK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAQDDLVKTK 10 1 P15311;E7EQR4 P15311 EZR Ezrin 1 12961800.0 4560900.0 5433500.0 2967400.0 True False 4416116.726010441 7603124.885328185 2190148.919908185 1.0 1.7216766125194602 0.49594452678491247 22.07434687500249 -6.747155865562598 1.6604184803510769 1.4257966317377049 0.4940327933137601 0.6366415332584883 0.30321961519380386 0.3050227033204176 1.6536563003401266 0.14431660323254003 0.35140778277308005 1.7899633321430197e-07 6.747155865562598 -0.9317638384239448 EAQDDLVK(ub)TK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAQDDLVKTK 10 1 P15311;E7EQR4 P15311 EZR Ezrin 1 22901800.0 8750200.0 9497500.0 4654100.0 True False 13274693.125307787 7802596.920693814 3734215.0950355083 1.0 0.5877798339321613 0.28130330846717233 23.662175174452724 -7.972136010076194 0.24728978185193223 1.1776139804008987 2.2032476936549534e-09 0.9996422408566057 0.005569631526506564 0.10444852270252505 0.043913674904046164 0.06527211615480442 0.09496001312145474 1.0662621425306864e-08 7.972136010076194 -1.1776139781976511 down EAQDDLVK(ub)TK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAQDDLVKTK 10 1 P15311;E7EQR4 P15311 EZR Ezrin 1 8866800.0 3280400.0 3403600.0 2182800.0 True False 4493252.529476712 3253217.6977999317 1667267.59617713 1.0 0.7240228935405071 0.3710602921245785 22.09932871571384 -6.967770812205254 0.30679506506717474 1.0564763995977888 0.02743890190862168 0.9999594028484114 0.0016400620869154786 0.07703285443360326 0.011605711031429817 0.005667355897962308 0.031435238013283 1.0770334405088794e-07 6.967770812205254 -1.0290374976891672 down EAQDDLVK(ub)TK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAQDDLVKTK 10 1 P15311;E7EQR4 P15311 EZR Ezrin 1 13678500.0 4560900.0 7320800.0 1796800.0 True False 3792590.4321287824 7281361.397334982 2172502.5725354655 1.0 1.9198913058608205 0.572828153056337 21.854752150436767 -6.722875043477273 1.7490754314332102 1.5579266131197111 0.5745951655387013 0.5260139643984866 0.386962980803814 0.34975529198914196 2.092637717565416 0.17556712726286253 0.439238280638211 1.8928881678140292e-07 6.722875043477273 -0.9833314475810099 EAQDDLVK(ub)TK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAQDDLVKTK 10 1 P15311;E7EQR4 P15311 EZR Ezrin 1 20488300.0 8750200.0 8824400.0 2913700.0 True False 11327306.392228508 8333314.382728977 2383436.497086669 1.0 0.7356836739620937 0.210415116759083 23.433301496545173 -7.130714073064782 0.48474077844931934 1.0122731800219438 1.1732920725873425e-14 0.9994725399553634 0.007536736733092881 0.07936347729941264 0.030101136731374174 0.008996033324610134 0.042842414770800016 7.400923701228579e-08 7.130714073064782 -1.012273180021932 down EAQDIK(ub)FTEEIPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAQDIKFTEEIPLK 14 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 61306700.0 21112400.0 23603500.0 16590800.0 True False 27678560.85277242 20081949.805722386 14874143.166191213 1.0 0.7255416895604556 0.537388603595022 24.722265596183835 -7.96704038040847 0.11541845154132638 1.4464852291428039 2.2713421561509117e-13 0.9999836601404923 0.0007678163423011267 0.11221076409567218 0.018469804760887595 0.09964224806702301 0.11766748303962883 1.0788464071538536e-08 7.96704038040847 -1.4464852291425767 EAQDIK(ub)FTEEIPLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAQDIKFTEEIPLK 14 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 96988700.0 40166500.0 30949100.0 25873100.0 True False 38891436.44353054 43307237.02742439 19096158.9336377 1.0 1.113541719918355 0.491011921386984 25.21294918547599 -6.859682630098529 1.1875058121121589 1.0615450004689193 0.46107401715523166 0.9532308614792728 0.05854194191641001 0.14713473721016077 0.39446729150102233 0.03845729171402968 0.08972898784386353 1.381393378344762e-07 6.859682630098529 -0.6004709833136876 down EAQDIK(ub)FTEEIPLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAQDIKFTEEIPLK 14 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 191670000.0 60813000.0 53855000.0 77002000.0 True False 92257767.02582157 44244154.4789644 61782520.948824525 1.0 0.4795710529887541 0.6696728410035387 26.45916703856005 -10.068390413462383 5.065611618826912 1.000008120873273 0.5746219469944833 0.8697238564932223 0.0776087299769411 7.117915562579542e-06 1.3090897387731839e-06 0.07514576338207418 0.02504810989258787 8.542983873243601e-11 10.068390413462383 -0.42538617387878963 EAQDIK(ub)FTEEIPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAQDIKFTEEIPLK 14 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 62598800.0 21112400.0 22522700.0 18963700.0 True False 28918224.821157183 21527572.641390998 14484864.629661111 1.0 0.7444292578305488 0.5008905186691708 24.785475657706726 -6.9717108846150255 0.21340152168054027 1.1221014267898564 0.1163934768691722 0.9999928290052539 0.0005456669491210971 0.0757513618221944 0.007008216514972903 0.007099714230572154 0.025041655432383545 1.0673064042905857e-07 6.9717108846150255 -1.0057079499206842 EAQDIK(ub)FTEEIPLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAQDIKFTEEIPLK 14 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 113101500.0 40166500.0 48816800.0 24118200.0 True False 33400224.427656993 48553814.20902386 29161204.110042766 1.0 1.4536972442861482 0.8730840768212289 24.993354460910265 -6.698166670528837 1.836914626971237 1.2822159716395058 0.8748384687303657 0.40917846969144966 0.19157388329895958 0.39930903306548554 2.618067135755834 0.0832331968798896 0.2145787961468642 2.0037029125633981e-07 6.698166670528837 -0.4073775029091401 EAQDIK(ub)FTEEIPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAQDIKFTEEIPLK 14 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 158809200.0 60813000.0 89420000.0 8576200.0 True False 78723627.30344374 84443698.3935027 7015419.59924312 1.0 1.0726601566263034 0.08911453701443242 26.2302933606525 -6.889112340624925 1.027583748406698 1.0539773716931415 0.005966096854437414 0.9803251676936867 0.06277031206615949 0.11986806623837586 0.22606106637276596 0.0465957050337352 0.11580269241980463 1.290885312150454e-07 6.889112340624925 -1.048011274838704 down EAQELSLEK(ub)LQQAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAQELSLEKLQQAVR 15 1 J3KPT4;Q9H4I3;Q9H4I3-2 J3KPT4 TRABD TraB domain-containing protein 1 35917300.0 6059300.0 10285000.0 19573000.0 True False 7943800.978344668 8750518.090615993 17547773.71747358 1.0 1.1015530366974815 2.208989596455146 22.921398047785633 -6.924819303488336 0.78814004096862 0.9795434483307447 2.4090065017477937 0.9954188349195301 0.03706112817294089 0.09541773173336648 0.0915168740366924 0.03277654270707609 0.10320423204980864 1.1889968293692937e-07 6.924819303488336 1.4294630534170492 up EAQELSLEK(ub)LQQAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAQELSLEKLQQAVR 15 1 J3KPT4;Q9H4I3;Q9H4I3-2 J3KPT4 TRABD TraB domain-containing protein 1 59066000.0 10610000.0 14048000.0 34408000.0 True False 10273191.35762036 19657439.659352235 25395512.58212606 1.0 1.913469629354359 2.4720178665112074 23.292381087406117 -8.745122246371443 0.1632391439099593 2.6930113261377983e-20 3.340853789732984 0.9998215851124699 0.008104394912970013 0.2923812397635026 0.04750732843853605 0.5041573115371913 0.361146518638064 1.7983646353938427e-09 8.745122246371443 3.340853789732984 EAQELSLEK(ub)LQQAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAQELSLEKLQQAVR 15 1 J3KPT4;Q9H4I3;Q9H4I3-2 J3KPT4 TRABD TraB domain-containing protein 1 483832000.0 42742000.0 149160000.0 291930000.0 True False 64842738.858758196 122541232.60760061 234229907.54253533 1.0 1.8898219718097116 3.61227658894452 25.95044169360027 -6.960678621040217 0.42576182664663303 0.9284251381206668 4.639266854869216 0.999794545748768 0.01554293117157726 0.07945958790529836 0.020242160290086318 0.02237556518828936 0.1431634477957206 1.0947661962119108e-07 6.960678621040217 3.7108417167485497 EAQELSLEK(ub)LQQAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAQELSLEKLQQAVR 15 1 J3KPT4;Q9H4I3;Q9H4I3-2 J3KPT4 TRABD TraB domain-containing protein 1 35275800.0 6059300.0 6934500.0 22282000.0 True False 8299586.956425502 6628110.860675044 17019450.512194794 1.0 0.7986073156982338 2.050638254837298 22.984608109308525 -6.865695969168402 1.1566891338783012 0.8885948822452662 2.1181864301566926 0.9601918089288639 0.10952375015523613 0.14104472338675517 0.3554158364145012 0.07366377705116732 0.17320440007547797 1.362398104842303e-07 6.865695969168402 1.2295915479114266 up EAQELSLEK(ub)LQQAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAQELSLEKLQQAVR 15 1 J3KPT4;Q9H4I3;Q9H4I3-2 J3KPT4 TRABD TraB domain-containing protein 1 38332500.0 10610000.0 9576500.0 18146000.0 True False 8822685.10269603 9524909.493713576 21940244.70237564 1.0 1.0795930471102229 2.4867990239922713 23.072786362840393 -6.9185436997539345 0.8354558201103339 0.9672912841353689 2.706293250333155 0.9937667439075611 0.053915383639747766 0.09903630432316304 0.1101100444669697 0.046098886058318 0.13622305523863143 1.2063027010146813e-07 6.9185436997539345 1.7390019661977862 up EAQELSLEK(ub)LQQAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAQELSLEKLQQAVR 15 1 J3KPT4;Q9H4I3;Q9H4I3-2 J3KPT4 TRABD TraB domain-containing protein 1 288059000.0 42742000.0 99517000.0 145800000.0 True False 55330361.570779115 93978791.46752623 119265896.03433295 1.0 1.6985031147376053 2.1555235253933214 25.721568015692718 -8.414308240038078 0.13132201156927759 2.2275809434475918e-08 3.1883402292345235 0.9999440636588346 0.003553759225389159 0.12057856784823759 0.03097190763209118 0.3586062404247973 0.33213228726182364 3.852048618871378e-09 8.414308240038078 3.188340206958714 EAQLYAAQAHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAQLYAAQAHLK 12 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 0 71671300.0 21272000.0 21258300.0 29141000.0 False True 27887797.998341 18086644.50420439 26125768.860210396 1.0 0.6485504701834234 0.9368172009050185 24.733130688850625 -9.971679769389302 6.559018399141914 1.0000000373131448 0.7926838355442182 0.40815437856969916 0.11768440001470784 6.419450128437627e-08 1.009602839529593e-08 0.11394745071669368 0.037982476780446486 1.0673828746828002e-10 9.971679769389302 -0.20731620176892662 EAQLYAAQAHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAQLYAAQAHLK 12 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 0 43578600.0 13705500.0 5492100.0 24381000.0 False True 13270426.404511418 7685124.170923146 17994884.68567821 1.0 0.5791165963069965 1.3560140523864903 23.661711392251263 -6.759589955543823 1.6140500920367364 0.7553958184617842 1.358788904110146 0.6892334176316056 0.17701468149495572 0.2836300502136401 1.4562170547748448 0.08653534362534326 0.2080393433663978 1.739442369512291e-07 6.759589955543823 0.6033930856483618 EAQLYAAQAHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAQLYAAQAHLK 12 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 0 129500000.0 15475800.0 94774000.0 19250200.0 False True 23477920.03252937 77860839.22735815 15445389.53233761 1.0 3.316343147922797 0.6578687341526658 24.48480126637017 -6.676402813457414 1.9146125973540706 2.4702855268974044 0.6682444011954994 0.30774296347622676 0.9825033691387354 0.4465776947074691 3.1618213530128845 0.41223667600493535 1.0923050413165258 2.106673278191499e-07 6.676402813457414 -1.8020411257019049 EAQLYAAQAHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAQLYAAQAHLK 12 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 0 60999900.0 21272000.0 16583900.0 23144000.0 False True 29136833.25418499 15851168.462376377 17677863.865642074 1.0 0.5440250944257862 0.6067187779613271 24.796340750373517 -10.420379995560126 5.966447995228376 1.0001478209809482 0.5753719361936825 0.9839139799901977 0.02559458912626766 5.034440792648332e-05 4.890786493030269e-06 0.02479037828512193 0.008260618119921239 3.7985688669098586e-11 10.420379995560126 -0.4247758847872657 EAQLYAAQAHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAQLYAAQAHLK 12 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 0 30520200.0 13705500.0 10057500.0 6757200.0 False True 11396730.506597612 10003318.251242552 8170099.278237223 1.0 0.8777357897031602 0.7168809750750463 23.44211666768554 -6.96734500037925 0.31522386384703704 1.0233008919300417 0.5661638041068742 0.99995364093472 0.0007893866970243164 0.0771739994969454 0.012099605379763937 0.0024872317074399685 0.014210402135572234 1.0780899551470933e-07 6.96734500037925 -0.45713708782316753 EAQLYAAQAHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAQLYAAQAHLK 12 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 0 58159400.0 15475800.0 28358000.0 14325600.0 False True 20033728.17362462 26779852.371314563 11718487.793068865 1.0 1.336738331439055 0.584937945224635 24.25592758846262 -6.784937729679442 1.5165245401058176 1.1894471224579966 0.5780223172013987 0.7845076854752917 0.14273386237002506 0.24297649438027552 1.1039623643155585 0.07410668977861701 0.17416115233604104 1.6408250222751791e-07 6.784937729679442 -0.6114248052565978 EAQMAAK(ub)LER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAQMAAKLER 10 1 P16949;P16949-2 P16949 STMN1 Stathmin 1 9466900.0 3467400.0 4535300.0 1464200.0 True False 4545794.978349369 3858650.918460938 1312698.629598162 1.0 0.848839628016409 0.28877207085894974 22.116101187402357 -6.946635646698022 0.5946336927634918 1.0063902826696833 0.10281437602032358 0.9989101198046709 0.010099958199608338 0.08486549110172545 0.04177496806411691 0.01042163419311537 0.046986204667956125 1.1307441597304415e-07 6.946635646698022 -0.9035759066493597 down EAQMAAK(ub)LER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAQMAAKLER 10 1 P16949;P16949-2 P16949 STMN1 Stathmin 1 16339300.0 5465100.0 7436300.0 3437900.0 True False 5291613.391944498 10405653.369792197 2537410.8552107406 1.0 1.9664424815374606 0.4795155403970893 22.335276230733097 -6.731274910537701 1.7184794405923418 1.5807724110067063 0.48017721336907615 0.5652023666919916 0.4062307542215733 0.33385793278007997 1.9321023213679696 0.18728101964752555 0.46407399442305886 1.856628827885354e-07 6.731274910537701 -1.10059519763763 EAQMAAK(ub)LER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAQMAAKLER 10 1 P16949;P16949-2 P16949 STMN1 Stathmin 1 24159900.0 10892000.0 7271200.0 5996700.0 True False 16523960.311861731 5973597.549855105 4811449.616553016 1.0 0.36151125015514324 0.29118017265504537 23.97805616437968 -13.999999999999998 0.31147250093635476 7.225295625237925 0.27584928377078854 0.9996752283212198 0.005746290996045479 17.375225708999654 0.1776307461596926 70.15954670315777 0.024226071383483753 1.0000000000000041e-14 13.999999999999998 -6.949446341467136 EAQMAAK(ub)LER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAQMAAKLER 10 1 P16949;P16949-2 P16949 STMN1 Stathmin 1 8906900.0 3467400.0 3830800.0 1608700.0 True False 4749391.4829616975 3661542.589238439 1228758.1922164864 1.0 0.770949836915764 0.2587190794072505 22.17931124892525 -6.967788836132098 0.46827248227273544 1.0137690641701533 9.61804257246033e-22 0.9996817934436288 0.005528098983373669 0.07890869360804348 0.024119740085051133 0.006995014967853307 0.04140864640530963 1.0769887427981495e-07 6.967788836132098 -1.0137690641701533 down EAQMAAK(ub)LER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAQMAAKLER 10 1 P16949;P16949-2 P16949 STMN1 Stathmin 1 17579200.0 5465100.0 9598500.0 2515600.0 True False 4544472.794980599 9546790.975346925 3041600.329179776 1.0 2.1007477447970246 0.6692966305220804 22.115681506167373 -6.701369687414842 1.8268632680637114 1.6826327376621126 0.673562551433772 0.42373142699214195 0.46452618278126623 0.39265077064427867 2.5488400902120425 0.20282340195145696 0.5205582460118339 1.9889795257429506e-07 6.701369687414842 -1.0090701862283407 EAQMAAK(ub)LER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAQMAAKLER 10 1 P16949;P16949-2 P16949 STMN1 Stathmin 1 26778900.0 10892000.0 10693000.0 5193900.0 True False 14099908.713418324 10097925.150097566 4248663.493914417 1.0 0.7161695409054508 0.30132560290061544 23.74918248647213 -7.048393159553227 0.3618447664584644 1.037081158880662 2.9457380193726043e-12 0.999911605992134 0.0026973666465094845 0.07309748492951193 0.015260066246106372 0.005818880886436781 0.03359319411154739 8.945545735382606e-08 7.048393159553227 -1.0370811588777165 down EAQMWK(ub)VNVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAQMWKVNVR 10 1 Q14094;D6RG12;D6RH01;D6RDK3 Q14094 CCNI Cyclin-I 1 17736780.0 863180.0 1394900.0 15478700.0 True False 1131637.3390470117 1186786.3572776145 13877112.60617474 1.0 1.0487338269317321 12.262862073693242 20.10998025453721 -6.907851798809229 0.9102218083482685 0.6287597296839804 13.647514869634445 0.9900857618341992 0.5275147919714485 0.10585625575864073 0.14659285656574816 0.42734760101762015 1.1628574197659762 1.236369267350687e-07 6.907851798809229 13.018755139950464 up EAQMWK(ub)VNVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAQMWKVNVR 10 1 Q14094;D6RG12;D6RH01;D6RDK3 Q14094 CCNI Cyclin-I 1 13171600.0 2228100.0 3587100.0 7356400.0 True False 2157370.185100277 5019447.736479383 5429538.152730538 1.0 2.3266511102943017 2.516739218067096 21.040842320410153 -10.530846180944865 0.39499725697437593 6.448038310973361e-19 2.535234137872696 0.9992886454438019 0.01799431801048183 2.014189732570007 0.187558194492861 2.06709306525852 0.04910625210554823 2.945464678064375e-11 10.530846180944865 2.535234137872696 EAQMWK(ub)VNVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAQMWKVNVR 10 1 Q14094;D6RG12;D6RH01;D6RDK3 Q14094 CCNI Cyclin-I 1 15652680.0 863180.0 1823800.0 12965700.0 True False 1182320.9725624037 1743218.4854999143 9903468.696973538 1.0 1.4744037583312903 8.376294531518027 20.1731903160601 -6.920802531068867 0.8187520671387778 0.8520742590828937 9.51009634959523 0.994400948984325 0.252238831464758 0.09770197292942626 0.10318417403211497 0.21825788750489478 0.6588877154143622 1.2000448263209058e-07 6.920802531068867 8.658022090512336 up EAQMWK(ub)VNVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAQMWKVNVR 10 1 Q14094;D6RG12;D6RH01;D6RDK3 Q14094 CCNI Cyclin-I 1 19164600.0 2228100.0 5654400.0 11282100.0 True False 1852763.871566167 5623938.624889483 13641134.94746348 1.0 3.0354319356062835 7.362586866470167 20.82124759584443 -6.9588332755808855 0.45157628470622924 0.862684666370428 9.707327938853172 0.9997244498041866 0.044040435635358796 0.08012056194491421 0.022691348103912618 0.057974282744844875 0.35784507412062955 1.0994278256498738e-07 6.9588332755808855 8.844643272482745 EAQQVYGGK(ub)EAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAQQVYGGKEAR 12 1 Q9H7Z7;X6RJ95;A6NHH0 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 10359900.0 3305100.0 3274800.0 3780000.0 True False 3200181.4096202715 4582444.717856392 2789904.602430729 1.0 1.4319327973348042 0.8717957657162239 21.609722259230978 -6.700698195916394 1.8278625255789953 1.2680125676989176 0.873408384147335 0.4212056696491099 0.182298687959483 0.3940303732482579 2.5598029330648515 0.07954169515970455 0.2044234106795163 1.9920571975688024e-07 6.700698195916394 -0.39460418355158255 EAQQVYGGK(ub)EAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAQQVYGGKEAR 12 1 Q9H7Z7;X6RJ95;A6NHH0 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 8477820.0 2171020.0 3090200.0 3216600.0 True False 2973704.7636094764 2953664.746075137 2456905.3279564595 1.0 0.9932609256374144 0.8262102405130068 21.503829989673562 -6.915395205814319 0.8581769824686972 1.0043321689270188 0.8019313402047786 0.9928034067581065 0.006819188770295482 0.10095758900567069 0.12021207968892396 0.005736405088356869 0.01649471538275928 1.21507978084997e-07 6.915395205814319 -0.2024008287222402 EAQQVYGGK(ub)EAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAQQVYGGKEAR 12 1 Q9H7Z7;X6RJ95;A6NHH0 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 28409310.0 6277910.0 7492400.0 14639000.0 True False 8126878.251106867 7075441.353651081 11974852.208824422 1.0 0.8706222900149166 1.4734873390275618 22.954269850709654 -6.850572261412425 1.2324127998717556 0.9309272150316306 1.4978429834250615 0.9411216143726213 0.06287963021183575 0.15683010273736298 0.4581027865988815 0.039919499643024665 0.09240560238813186 1.4106774970503303e-07 6.850572261412425 0.5669157683934309 EAQTSFLHLGYLPNQLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAQTSFLHLGYLPNQLFR 18 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 45688000.0 18827000.0 13447000.0 13414000.0 False True 24682379.320927322 11440760.015995458 12026047.956173832 1.0 0.46351933366064263 0.4872321180955747 24.556978137671656 -10.254753362499903 5.53911050914323 1.0000390701339008 0.475375725878101 0.9984700937346412 0.009680703707768535 4.671171838391774e-06 6.284710191870685e-07 0.0093739966639949 0.003124433686636248 5.562200470884669e-11 10.254753362499903 -0.5246633442557997 EAQTSFLHLGYLPNQLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAQTSFLHLGYLPNQLFR 18 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 194088200.0 72837500.0 61964500.0 59286200.0 False True 70525313.4317317 86707247.99059866 43757365.67212399 1.0 1.2294486018063717 0.6204490776844401 26.071637836726037 -6.804637196208334 1.4369255747316345 1.1258617872118806 0.6110493367795379 0.8453725623381679 0.09875017079415181 0.21420287323315917 0.8726170064871599 0.05405291113512529 0.1253680609760198 1.5680604598085284e-07 6.804637196208334 -0.5148124504323427 EAQTSFLHLGYLPNQLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAQTSFLHLGYLPNQLFR 18 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 82864000.0 22493000.0 33329000.0 27042000.0 False True 34123525.458566494 27381179.549334414 21697136.847070333 1.0 0.8024135601868342 0.635841008673487 25.02426337003668 -6.973098860610772 0.168439872161451 1.1502989761512343 0.28350132739345274 0.999997562944333 0.00023229422372020823 0.07530936407015654 0.005245310669498027 0.007121498978408129 0.019400610149740587 1.0639008096303439e-07 6.973098860610772 -0.8667976487577815 EAQTSFLHLGYLPNQLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAQTSFLHLGYLPNQLFR 18 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 189906800.0 18827000.0 26246800.0 144833000.0 False True 25787850.680544414 25087129.589439183 110626428.32926632 1.0 0.9728274721385025 4.289866173791994 24.620188199194548 -6.905051665085533 0.9287645495597012 0.8805449747553132 4.676105011709507 0.988916678107049 0.16394863045573663 0.10778219964916365 0.15718548288952638 0.1310259130946334 0.3504193825121211 1.244366569067304e-07 6.905051665085533 3.7955600369541935 up EAQTSFLHLGYLPNQLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAQTSFLHLGYLPNQLFR 18 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 163572000.0 72837500.0 38157800.0 52576700.0 False True 60567608.49836214 37952236.35766969 63570244.88280577 1.0 0.6266094583988071 1.0495749536573633 25.852043112160313 -6.673661407725822 1.9244494486817383 0.7624214255073919 1.047893948594299 0.2953691608746889 0.1584753955950954 0.4527478202148113 3.2360351775836746 0.06621440237094536 0.1760643985972865 2.120013333051084e-07 6.673661407725822 0.2854725230869072 EAQTSFLHLGYLPNQLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAQTSFLHLGYLPNQLFR 18 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 66178000.0 22493000.0 27192000.0 16493000.0 False True 29117631.90331607 25678741.296310958 13491443.232470872 1.0 0.8818966247521841 0.4633427360188036 24.79538969212913 -6.9476579233925095 0.5839934479779645 1.0049318935040006 0.3194627233589053 0.9990044128552011 0.007265068239813362 0.08444012419881729 0.03996173060548282 0.007579403587839468 0.035003033531902025 1.1280856548377164e-07 6.9476579233925095 -0.6854691701450952 down EASDPQPEEADGGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EASDPQPEEADGGLK 15 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 7064470.0 1775200.0 463170.0 4826100.0 False True 1718847.2476953526 648116.1963996424 3561999.630103423 1.0 0.3770644525094612 2.072318895631585 20.71300990891364 -6.807237353832317 1.4260477157136866 0.6593774292759845 2.1001568093228355 0.8525038996682338 0.26889153232525764 0.2105949781137601 0.8445718464052331 0.14828324698428855 0.3434694584279608 1.5587003975292223e-07 6.807237353832317 1.440779380046851 up EASDPQPEEADGGLK(ub)SWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EASDPQPEEADGGLKSWR 18 1 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 1 7946000.0 2151000.0 3019800.0 2775200.0 True False 2819981.8303136323 2569257.611088204 2488048.9255981524 1.0 0.9110901295425925 0.8822925377932088 21.42725443641602 -13.999995442220643 0.15766639862204082 1.4357780175834316 0.8532413058653018 0.9995426893948486 0.001071345599483794 11.994866081112896 0.12539708758813312 1.598868037474051 0.0264020802869 1.000010494729875e-14 13.999995442220643 -0.5825367117181298 EASGTDVK(ub)QLDQGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EASGTDVKQLDQGNK 15 1 Q8N0X7 Q8N0X7 SPG20 Spartin 1 5134200.0 1948800.0 1781800.0 1403600.0 True False 2554895.6722060437 1515962.385402003 1258368.9362819162 1.0 0.5933558860714786 0.4925324153042101 21.28483295001193 -13.999999999999998 0.1958539128101586 3.2257611930204253 0.4243116533892666 0.9994872399548852 0.00496710840048779 12.451989906096207 0.14034003092914224 10.599307337417274 0.06624212920229706 1.0000000000000041e-14 13.999999999999998 -2.8014495396311587 EASHK(ub)QIMENAEINNIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EASHKQIMENAEINNIIK 18 1 P11388;P11388-2;P11388-3;P11388-4;Q02880;Q02880-2;E9PCY5 P11388;Q02880 TOP2A;TOP2B DNA topoisomerase 2-alpha;DNA topoisomerase 2-beta;DNA topoisomerase 2 1 7213300.0 1545500.0 2640300.0 3027500.0 True False 2026165.4666432894 2246377.5318087926 2714243.341830648 1.0 1.1086841468729227 1.3395960924787078 20.950320565851182 -6.958845641592155 0.45140904520018116 0.9926598833071189 1.464795963138365 0.999724956912429 0.00234836696454318 0.08011609929732895 0.022674677769931276 0.003092920130937239 0.019096302568938944 1.099396521214999e-07 6.958845641592155 0.47213607983124606 EASHK(ub)QIMENAEINNIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EASHKQIMENAEINNIIK 18 1 P11388;P11388-2;P11388-3;P11388-4;Q02880;Q02880-2;E9PCY5 P11388;Q02880 TOP2A;TOP2B DNA topoisomerase 2-alpha;DNA topoisomerase 2-beta;DNA topoisomerase 2 1 9479400.0 2335200.0 1613500.0 5530700.0 True False 2261070.3542238534 2257778.964291341 4082043.7525565177 1.0 0.9985443221939717 1.8053590172154288 21.108574452218896 -6.906490908577737 0.919303007836354 0.9721629936417557 1.902162631368623 0.9895284094792943 0.03888502968446264 0.10678469376458471 0.15169446721681765 0.03129327244153367 0.08442068474083128 1.2402495879509406e-07 6.906490908577737 0.9299996377268673 EASHK(ub)QIMENAEINNIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EASHKQIMENAEINNIIK 18 1 P11388;P11388-2;P11388-3;P11388-4;Q02880;Q02880-2;E9PCY5 P11388;Q02880 TOP2A;TOP2B DNA topoisomerase 2-alpha;DNA topoisomerase 2-beta;DNA topoisomerase 2 1 13476700.0 1545500.0 4272000.0 7659200.0 True False 2116913.1155670807 4083248.914385146 5850254.706175495 1.0 1.9288693921154725 2.76357809073724 21.013530627374074 -6.9723931653712965 0.19263202003271354 0.45337350898694734 4.261939733793967 0.9999955286069621 0.0015231532964219844 0.0755335412873103 0.006164543480504994 0.028817611659337897 0.09033913191805831 1.0656309721959585e-07 6.9723931653712965 3.8085662248070196 EASHK(ub)QIMENAEINNIIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EASHKQIMENAEINNIIK 18 1 P11388;P11388-2;P11388-3;P11388-4;Q02880;Q02880-2;E9PCY5 P11388;Q02880 TOP2A;TOP2B DNA topoisomerase 2-alpha;DNA topoisomerase 2-beta;DNA topoisomerase 2 1 11758800.0 2335200.0 3998000.0 5425600.0 True False 1941822.266900639 3976461.980459133 6560067.874859989 1.0 2.0477991463173413 3.378305000761257 20.888979727653172 -6.967877593483138 0.30464534493345247 0.7816215098921765 4.686450567755463 0.9999607746239868 0.0060953077428562855 0.07699756272216757 0.011482144470800182 0.02158075954357514 0.11875311986134066 1.0767686596413025e-07 6.967877593483138 3.9048290578632865 EASIDILHSIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EASIDILHSIVK 12 0 O00231;O00231-2;J3QRY4 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 17784200.0 3470300.0 5043200.0 9270700.0 False True 4549596.906433004 4290774.218239631 8311456.8948338255 1.0 0.9431108527818354 1.8268556678244738 22.11730729774505 -6.891539131623693 1.0132546396835986 0.9542524680717868 1.9051920536316196 0.9818645361071302 0.05438711005884788 0.11790241042260254 0.21463462124172147 0.040814032529845716 0.10232824224676694 1.2836920996052797e-07 6.891539131623693 0.9509395855598328 EASIDILHSIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EASIDILHSIVK 12 0 O00231;O00231-2;J3QRY4 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 8064600.0 3249600.0 1732000.0 3083000.0 False True 3146443.2267411053 2423596.6322606793 2275469.8119825213 1.0 0.7702654895098467 0.7231879452467714 21.58529048101278 -13.999999999999986 0.22281862301443883 2.4036959650203777 0.6986762388276954 0.9995008712678802 0.002701740214476087 13.077869575004787 0.14951610368407295 8.089528285077737 0.025577996521344678 1.0000000000000327e-14 13.999999999999986 -1.7050197261926825 EASIDILHSIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EASIDILHSIVK 12 0 O00231;O00231-2;J3QRY4 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 15300400.0 3470300.0 5175600.0 6654500.0 False True 4753363.691331246 4946924.878579534 5082844.153729487 1.0 1.0407208873163414 1.0693152226073335 22.18051735926794 -6.97492005469407 0.07613302716737709 0.8919563510498602 1.2187960062373189 0.9999998769294942 8.137743616692072e-06 0.07473630030152915 0.002204040689881399 0.003660249771753051 0.005766615702742717 1.0594487314721553e-07 6.97492005469407 0.3268396551874587 EASIDILHSIVK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 EASIDILHSIVKR 13 1 O00231;O00231-2;J3QRY4 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 1 15252000.0 3444800.0 5421300.0 6385900.0 True False 4516166.159490649 4612463.172061885 5725148.325878224 1.0 1.0213227346316454 1.2677009932079049 22.10666713627283 -6.923944656140183 0.7949049589699035 0.9952973192402376 1.3112776320148485 0.9952087935302696 0.00840879981076007 0.09590572888320457 0.09398616436215071 0.0074007954653715815 0.02307944651047689 1.1913938223707633e-07 6.923944656140183 0.3159803127746109 EASIDILHSIVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 EASIDILHSIVKR 13 1 O00231;O00231-2;J3QRY4 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 1 24075700.0 3487600.0 9949100.0 10639000.0 True False 3376888.047015718 13921827.513871077 7852326.736841417 1.0 4.122679615089495 2.325314498886278 21.687262920214568 -9.808947511796953 6.314035556247905 0.999999933254825 3.2239970569888468 0.6712073159212 0.7337712360327836 6.950721931930932e-07 1.3078382677921803e-07 0.7104709654417138 0.2368236480895777 1.5525746405453416e-10 9.808947511796953 2.223997123734022 EASIDILHSIVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 EASIDILHSIVKR 13 1 O00231;O00231-2;J3QRY4 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 1 88225600.0 8252600.0 28801000.0 51172000.0 True False 12519797.545874972 23661236.52675989 41057831.770515606 1.0 1.8899056825847638 3.2794325643103837 23.577707897254932 -6.96458196003448 0.3651623967269594 0.887108682141306 4.330231116506747 0.9999042586130374 0.00917805798147453 0.07810318404782302 0.015362344333399185 0.01846103560500721 0.11832686904341977 1.084970774676557e-07 6.96458196003448 3.4431224343654407 EASIDILHSIVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EASIDILHSIVKR 13 1 O00231;O00231-2;J3QRY4 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 1 22002400.0 3444800.0 3491600.0 15066000.0 True False 4718435.652219653 3337329.5668228413 11507721.094009833 1.0 0.7072957676667456 2.4388848216243777 22.16987719779572 -6.863399344025775 1.168348330086459 0.8395000164591104 2.5283849457307794 0.9576452709580219 0.15574766213759886 0.14334616207196385 0.36989076123278014 0.10381393007847904 0.2433525199995426 1.369621787405941e-07 6.863399344025775 1.688884929271669 up EASIDILHSIVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EASIDILHSIVKR 13 1 O00231;O00231-2;J3QRY4 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 1 31485600.0 3487600.0 14596000.0 13402000.0 True False 2900093.9268767834 14517368.45092083 16204296.236153344 1.0 5.005826989388275 5.587507385874339 21.467668195648844 -9.72220740483929 0.5126883837643224 1.553648192388669e-21 5.5694937994640386 0.9988737122989517 0.06844073093282636 1.012368849853661 0.22848192862934533 1.9064008286045906 0.11482198962896313 1.8958003327591418e-10 9.72220740483929 5.5694937994640386 EASIDILHSIVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EASIDILHSIVKR 13 1 O00231;O00231-2;J3QRY4 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 1 62176600.0 8252600.0 25392000.0 28532000.0 True False 10683153.383066114 23978912.87863808 23339468.763042435 1.0 2.244553833388473 2.184698461789182 23.34883421934738 -10.144133951710891 5.173393110014708 0.9999546390288622 2.214626147585169 0.9981820077152644 0.024435853134498066 1.2785919750201556e-05 2.115221361625354e-06 0.02366078951056874 0.00788663768611367 7.17572932375667e-11 10.144133951710891 1.214671508556307 EASK(ub)QADVNLVNAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EASKQADVNLVNAK 14 1 A0A2C9F2M7;O43175;A0A286YF22 A0A2C9F2M7 PHGDH D-3-phosphoglycerate dehydrogenase 1 7833700.0 2716100.0 2977600.0 2140000.0 True False 3560833.402749817 2533353.6865938967 1918573.3283295096 1.0 0.7114496523868655 0.5387989583696645 21.76378350863395 -10.226543541152454 0.09095036706633558 1.8501794657701127 1.8532758595538866e-10 0.9999447282295347 0.0014144458842557425 1.9530351622468483 0.04559177324435883 0.6674069285605004 0.29649609090397266 5.935488376586253e-11 10.226543541152454 -1.8501794655847852 EASK(ub)QADVNLVNAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EASKQADVNLVNAK 14 1 A0A2C9F2M7;O43175;A0A286YF22 A0A2C9F2M7 PHGDH D-3-phosphoglycerate dehydrogenase 1 10391300.0 2929900.0 2549400.0 4912000.0 True False 2836891.9282461796 3567388.714945367 3625399.8431586633 1.0 1.2574989831039474 1.2779478157280226 21.435879761334736 -12.439331646680419 0.38445217775198515 6.226980586333336e-09 1.279721883253017 0.9997470069746628 0.002011780577018205 7.543508074086787 0.19944144344476916 6.037470050949864 0.005468781887847014 3.6363724041982824e-13 12.439331646680419 1.2797218770260366 EASK(ub)QADVNLVNAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EASKQADVNLVNAK 14 1 A0A2C9F2M7;O43175;A0A286YF22 A0A2C9F2M7 PHGDH D-3-phosphoglycerate dehydrogenase 1 24077900.0 7928500.0 7282300.0 8867100.0 True False 12028114.150991159 5982716.668130408 7114513.798412012 1.0 0.49739440389642553 0.5914903790488013 23.519907128979305 -10.104967750748301 5.424324823889361 1.000006362055608 0.5444423914724709 0.9689945462212687 0.038414520996197826 2.955604106764441e-06 4.876559798424867e-07 0.037195219384454546 0.012398233339131282 7.852939457397596e-11 10.104967750748301 -0.455563970583137 EASK(ub)QADVNLVNAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EASKQADVNLVNAK 14 1 A0A2C9F2M7;O43175;A0A286YF22 A0A2C9F2M7 PHGDH D-3-phosphoglycerate dehydrogenase 1 6517100.0 2716100.0 1667100.0 2133900.0 True False 3720315.5698426086 1593442.009637519 1629916.769050017 1.0 0.4283082925959776 0.4381125037516568 21.82699357015684 -10.511818867495906 6.224283528451417 1.000518613827881 0.43321039817381723 0.9997756395607644 0.004002552443652813 2.8830048458231277e-05 2.261186318300658e-06 0.0038787853675091273 0.0012918182463824246 3.077380039259711e-11 10.511818867495906 -0.5673082156540638 EASK(ub)QADVNLVNAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EASKQADVNLVNAK 14 1 A0A2C9F2M7;O43175;A0A286YF22 A0A2C9F2M7 PHGDH D-3-phosphoglycerate dehydrogenase 1 9214200.0 2929900.0 4555500.0 1728800.0 True False 2436341.6665776772 4530958.617304046 2090284.0869319427 1.0 1.859738590633994 0.8579601603531082 21.216285036769012 -6.679548121169142 1.903611458511579 1.5441869663555419 0.8617959250262663 0.3220354160973178 0.3644133987478213 0.439509423677725 3.0789067191813273 0.15363409675099646 0.4054167338820756 2.091471152804019e-07 6.679548121169142 -0.6823910413292755 EASK(ub)QADVNLVNAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EASKQADVNLVNAK 14 1 A0A2C9F2M7;O43175;A0A286YF22 A0A2C9F2M7 PHGDH D-3-phosphoglycerate dehydrogenase 1 21241100.0 7928500.0 6552900.0 6759700.0 True False 10263599.544099996 6188225.354537951 5529503.960379158 1.0 0.6029293453966875 0.5387489970375724 23.291033451071755 -13.999999999999998 0.2564772779469845 3.8541439601451013 0.5144877750280092 0.9995552315066178 0.004302219429510642 14.264311292681725 0.16025392384814333 21.056243434643218 0.028589388241075483 1.0000000000000041e-14 13.999999999999998 -3.339656185117092 EASSTQDTGK(ub)LPVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EASSTQDTGKLPVK 14 1 P41240 P41240 CSK Tyrosine-protein kinase CSK 1 3990540.0 1167600.0 2049500.0 773440.0 True False 970911.1334503195 2038458.936706102 935162.728017491 1.0 2.0995319411592757 0.9631805587543428 19.888979727653172 -6.65363778766432 1.9952277999141295 1.7114057690878468 0.9679197868655012 0.2090880581749459 0.4688711770844959 0.4996587137285996 3.8166108604251354 0.19029884396680494 0.5195575986734423 2.220047222158608e-07 6.65363778766432 -0.7434859822223456 EASSTQDTGK(ub)LPVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EASSTQDTGKLPVK 14 1 P41240 P41240 CSK Tyrosine-protein kinase CSK 1 8770000.0 1705500.0 1441900.0 5622600.0 True False 2207803.370431043 1361656.9974680338 4599344.492747879 1.0 0.6167474040961306 2.0832219727293557 21.074180259041736 -6.837265780726311 1.2949614773828406 0.7959893314819647 2.1289246163368114 0.9196650816295415 0.17601339558118856 0.17201344481527195 0.5614906289757772 0.10662433419986077 0.2455008684103048 1.454568637243958e-07 6.837265780726311 1.3329352848548468 up EATDAIGHLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EATDAIGHLDR 11 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 9378690.0 2762230.0 901760.0 5714700.0 False True 2674544.520618258 1261837.4706162754 4217848.632674832 1.0 0.4717952761259641 1.5770343698372304 21.350861788390773 -6.77676841778082 1.5485720974355988 0.699652517636655 1.5848984834069255 0.7557160543350063 0.2230844567386592 0.2556477093904211 1.2106891854458142 0.11349214314688102 0.26851396613182615 1.6719819405594295e-07 6.77676841778082 0.8852459657702705 EATELNEDGSQVK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 EATELNEDGSQVKR 14 1 A6NED2 A6NED2 RCCD1 RCC1 domain-containing protein 1 1 28498540.0 8577200.0 8301340.0 11620000.0 True False 11244792.26172295 7062812.430369887 10417673.866910707 1.0 0.6280963014685083 0.9264443152384648 23.42275367297062 -9.903557027248231 6.368875950770425 1.000000023156284 0.7772703083534674 0.42631023941758805 0.12180006658494227 4.0102421573673024e-08 6.898117417372444e-09 0.1179324196638744 0.039310802454192925 1.248656472629157e-10 9.903557027248231 -0.22272971480281656 EATELNEDGSQVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 EATELNEDGSQVKR 14 1 A6NED2 A6NED2 RCCD1 RCC1 domain-containing protein 1 1 45164460.0 9055980.0 7734180.0 28374300.0 True False 8768502.871892823 10822478.40721589 20942219.619246088 1.0 1.2342447240231882 2.388346097983928 23.063899108268394 -6.940135434803821 0.658313465552731 0.9870750419188917 2.700802820628555 0.9981814486123959 0.025878500009369903 0.08770511712656087 0.05433102004550179 0.025216527069933492 0.09927220189287869 1.1477956254293781e-07 6.940135434803821 1.713727778709663 up EATELNEDGSQVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 EATELNEDGSQVKR 14 1 A6NED2 A6NED2 RCCD1 RCC1 domain-containing protein 1 1 200448400.0 13478400.0 31603000.0 155367000.0 True False 20447718.20302949 25963197.734634016 124658644.35022466 1.0 1.2697356974915355 6.096457468381753 24.28543652347424 -6.9184166626397055 0.8363987376382185 0.8873038365641075 6.84712071808995 0.9937294433936286 0.18541652417863527 0.0991121321828692 0.11051191599238573 0.15843031772568372 0.46761409343160015 1.206655612773322e-07 6.9184166626397055 5.9598168815258425 up EATELNEDGSQVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EATELNEDGSQVKR 14 1 A6NED2 A6NED2 RCCD1 RCC1 domain-containing protein 1 1 35856410.0 8577200.0 7106640.0 20172570.0 True False 11748422.630114501 6792645.146284193 15408224.433120271 1.0 0.578175075935108 1.3115143128767492 23.485963734493513 -6.7507188005368475 1.6471180486709123 0.7521748943556122 1.313056815083877 0.6520606450319091 0.17726080487924475 0.2988059144291906 1.595179738890982 0.08500502947283571 0.20621910841198393 1.77533861517782e-07 6.7507188005368475 0.5608819207282648 EATELNEDGSQVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EATELNEDGSQVKR 14 1 A6NED2 A6NED2 RCCD1 RCC1 domain-containing protein 1 1 53742180.0 9055980.0 16068400.0 28617800.0 True False 7530448.617937153 15981836.339872314 34601649.66624303 1.0 2.1222953838107834 4.594898846241859 22.84430438370267 -6.95810939565692 0.46130639356397 0.9288606150153527 5.8882277769812745 0.9996935266633515 0.02628977465668096 0.08038351296306792 0.023679891503765226 0.03365593970562811 0.20423341141265516 1.1012618746540558e-07 6.95810939565692 4.959367161965922 EATELNEDGSQVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EATELNEDGSQVKR 14 1 A6NED2 A6NED2 RCCD1 RCC1 domain-containing protein 1 1 148520900.0 13478400.0 23687500.0 111355000.0 True False 17448054.49898435 22369269.802014034 91089532.59878711 1.0 1.282049514650252 5.220612567669904 24.05656284556669 -6.921323682288697 0.8148530776194979 0.917174897899448 5.875481850126275 0.9945407079473946 0.1423492737054659 0.09739915801729733 0.1016254845615234 0.12351598695843853 0.3748011839954108 1.198605642173186e-07 6.921323682288697 4.958306952226827 up EATNPPVIQEEKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EATNPPVIQEEKPK 14 1 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 17976400.0 3638700.0 1488700.0 12849000.0 False True 3523191.46022368 2083145.6734679393 9483461.438262558 1.0 0.5912666674480657 2.6917246891999658 21.748451446430636 -6.8562338034992 1.2046601493471871 0.7801024907055978 2.7863379732233517 0.9488888210539985 0.20556538717914669 0.1507349499496338 0.417831707564785 0.13328208964501864 0.30990914823162696 1.3924069954129605e-07 6.8562338034992 2.006235482517754 up EATVKPFAIDIFPVTNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EATVKPFAIDIFPVTNK 17 1 J3KQJ1;Q8NBJ7;C9J660;C9JL30;Q8NBJ7-3;A8MXB9;F8WA42;A0A494C1B1;H7C3B2;E9PBT8;J3QT17;E9PG02;F8WEX5;Q8NBJ7-5;F8WES7;Q8NBJ7-4;F8WEV7 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 8550700.0 2759400.0 3134500.0 2656800.0 False True 3617600.1220676126 2666844.818185303 2381899.821825159 1.0 0.7371861809483485 0.6584198754570479 21.786601515206687 -13.999999999996426 0.16885512103887126 2.321452205879439 0.5880853335099108 0.9995159083482795 0.003213204792838954 12.080622415451758 0.13010223521319866 5.228442691146197 0.06489296358326212 1.0000000000082296e-14 13.999999999996426 -1.7333668723695284 EATVKPFAIDIFPVTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EATVKPFAIDIFPVTNK 17 1 J3KQJ1;Q8NBJ7;C9J660;C9JL30;Q8NBJ7-3;A8MXB9;F8WA42;A0A494C1B1;H7C3B2;E9PBT8;J3QT17;E9PG02;F8WEX5;Q8NBJ7-5;F8WES7;Q8NBJ7-4;F8WEV7 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 10821500.0 2759400.0 2990000.0 5072100.0 False True 3779624.7499811095 2857891.9133922257 3874174.4431785014 1.0 0.7561311247648353 1.0250156297124111 21.84981157672958 -6.667920220518196 1.9445625993230466 0.8440587184942034 1.0239219502329089 0.26982413667761174 0.10364086773243024 0.46598739082178237 3.394983546639738 0.04293626078441177 0.11503461763368643 2.148225064780441e-07 6.667920220518196 0.17986323173870544 EATWTMSNITAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EATWTMSNITAGR 13 0 P52292 P52292 KPNA2 Importin subunit alpha-1 0 18311400.0 3897300.0 7002700.0 7411400.0 False True 5109398.041506885 5957924.456310801 6644539.423168849 1.0 1.1660716992316507 1.3004544506399847 22.284721900861207 -6.973532372960031 0.1516700070194259 0.8473881969758221 1.6226774366596646 0.9999984697947265 0.00015190360864647618 0.07517228449118507 0.004643404204315963 0.00674529984246475 0.016651183530258806 1.0628393546881778e-07 6.973532372960031 0.7752892396838424 EATWTMSNITAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EATWTMSNITAGR 13 0 P52292 P52292 KPNA2 Importin subunit alpha-1 0 11597400.0 3118700.0 0.0 8478700.0 False True 3019698.5755900736 0.0 6257874.114452232 1.0 0.0 2.0723505865910448 21.525973117151157 -6.775496488145979 1.553395835537677 0.43045351874485144 2.0865085684658875 0.751118389495725 0.42215526907904155 0.25764699359965 1.2276330754048443 0.21411738688169746 0.5071665797590328 1.6768858955678168e-07 6.775496488145979 1.656055049721036 EATWTMSNITAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EATWTMSNITAGR 13 0 P52292 P52292 KPNA2 Importin subunit alpha-1 0 9251800.0 3118700.0 3946100.0 2187000.0 False True 2593337.23183583 3924841.5760604786 2644291.588454507 1.0 1.513432779925067 1.0196481799563746 21.306378392585433 -10.65096536560944 2.8842771500333035 0.9737841332909709 1.2665404794850983 0.27979784749433334 0.2015867220854659 94183285.66198407 84582297.72479685 18195885.522066675 0.0757173763107383 2.233750354261225e-11 10.65096536560944 0.2927563461941274 EATWVVDVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EATWVVDVK 9 0 P22307-7;P22307-8;P22307;P22307-6;P22307-2;P22307-4;H0YF61 P22307-7 SCP2 Non-specific lipid-transfer protein 0 8189300.0 2214600.0 3222200.0 2752500.0 False True 2903362.0462169093 2741460.320037224 2467697.703844379 1.0 0.9442364666884573 0.8499448792684322 21.469293055072363 -6.963191284587117 0.3878643313904697 1.005930645003647 0.7848743873664059 0.9998708274937703 0.0007038267851640576 0.07858047131232174 0.017059802800049484 0.0012190000422009153 0.007938914342711871 1.0884505807286735e-07 6.963191284587117 -0.22105625763724102 EATWVVDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EATWVVDVK 9 0 P22307-7;P22307-8;P22307;P22307-6;P22307-2;P22307-4;H0YF61 P22307-7 SCP2 Non-specific lipid-transfer protein 0 9106300.0 2308100.0 1414800.0 5383400.0 False True 2234830.6288900645 1979737.0180845326 3973326.041461796 1.0 0.8858555062258902 1.777909247393464 21.09173406734599 -6.874760584490993 1.1085448416722787 0.933147345995284 1.8351193658399383 0.9692105853596669 0.06954944463330477 0.13237524445105223 0.3011603246037385 0.04853418375031561 0.1159615663137723 1.3342567713017892e-07 6.874760584490993 0.9019720198446542 EATWVVDVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EATWVVDVK 9 0 P22307-7;P22307-8;P22307;P22307-6;P22307-2;P22307-4;H0YF61 P22307-7 SCP2 Non-specific lipid-transfer protein 0 8982100.0 2214600.0 4012100.0 2755400.0 False True 3033397.4673146955 3834832.155759515 2104631.269244306 1.0 1.26420365187233 0.6938198148848008 21.532503116595255 -6.78073981818845 1.5328400944327363 1.1494548545095964 0.6891845744786121 0.7700431107030342 0.11176516589695619 0.2494293178589809 1.1576021678227548 0.05742384614632275 0.13542100060542342 1.6567622171518882e-07 6.78073981818845 -0.46027028003098425 EATWVVDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EATWVVDVK 9 0 P22307-7;P22307-8;P22307;P22307-6;P22307-2;P22307-4;H0YF61 P22307-7 SCP2 Non-specific lipid-transfer protein 0 4835710.0 2308100.0 1548900.0 978710.0 False True 1919287.416167081 1540555.768267421 1183353.7359562481 1.0 0.80267069709861 0.6165588988852271 20.872139342780265 -6.971833687827589 0.20983372972355166 1.097647295082718 0.3163878437478329 0.9999933683922082 0.0004031344016197693 0.0757121669217715 0.00685940810429832 0.005580551860135439 0.019293103358742687 1.0670046502236117e-07 6.971833687827589 -0.7812594513348852 EAVAMESYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAVAMESYAK 10 0 P78371;F5GWF6;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 0 16176500.0 2932900.0 6168100.0 7075500.0 False True 3845060.302244003 5247843.523065491 6343395.132988524 1.0 1.3648273656469871 1.6497517943441553 21.87457479353629 -6.973895705232779 0.13602708245078846 0.5958867073370828 2.426100936812243 0.9999990509119674 0.00025900557383720375 0.07505765758788625 0.004104872781726416 0.01679454688239495 0.03779537358757072 1.0619505514304325e-07 6.973895705232779 1.83021422947516 EAVAMESYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAVAMESYAK 10 0 P78371;F5GWF6;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 0 18059200.0 3903200.0 1956000.0 12200000.0 False True 3779295.052503665 2737041.000405251 9004454.007845202 1.0 0.7242199834575093 2.3825750259641763 21.849685724642658 -6.864177611509827 1.1645339357179485 0.8483797193059587 2.4694963636068272 0.9585141519873662 0.14777907949674912 0.14255514358906843 0.365024454284957 0.09879852081060257 0.23180748007322172 1.367169585898408e-07 6.864177611509827 1.6211166443008684 up EAVAMESYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAVAMESYAK 10 0 P78371;F5GWF6;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 0 15890500.0 2932900.0 5383500.0 7574100.0 False True 4017272.3886423125 5145639.169146168 5785253.573485979 1.0 1.2808788330345708 1.4400949235710596 21.93778485505918 -11.416783245203995 0.08775029567063192 9.639583650100401e-23 1.9197645002320916 0.9999182729446094 0.0016448010025759243 4.284233918522257 0.05901736598287087 1.1673553898894675 0.33042995976790873 3.830158574417556e-12 11.416783245203995 1.9197645002320916 EAVAMESYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAVAMESYAK 10 0 P78371;F5GWF6;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 0 5857700.0 3903200.0 1954500.0 0.0 False True 3245683.741078532 1943970.7205621249 0.0 1.0 0.5989402775010201 0.0 21.630091000076934 -7.654381858125321 0.660627587951134 0.998462263949208 1.313111782372251e-15 0.9872875628926695 0.04632918925968976 0.12094753541782811 0.14902364910742294 0.04257674068999115 0.07761126628249697 2.2162469037738257e-08 7.654381858125321 -0.9984622639492067 down EAVAMESYAK(ub)ALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAVAMESYAKALR 13 1 P78371;F5GWF6;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 1 14642400.0 4326900.0 3652000.0 6663500.0 True False 4189544.92792531 5110262.644928408 4918129.449284961 1.0 1.2197655671063643 1.1739054083185239 21.998362114947952 -10.142552881577679 4.688636183850415 0.9999812135254396 1.196835487714555 0.9608803531506694 0.0187223314327718 3.6770001859910593e-06 6.724699569362787e-07 0.018129549015076463 0.006042606485751148 7.20190052438179e-11 10.142552881577679 0.1968542741891155 EAVAMESYAK(ub)ALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAVAMESYAKALR 13 1 P78371;F5GWF6;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 1 75084300.0 5602300.0 12313000.0 57169000.0 True False 8499098.682991458 10115648.948091894 45869522.09193712 1.0 1.1902025526936761 5.396986645623023 23.018878422983352 -6.916358184597001 0.8513018240372567 0.8944491242738385 6.021621558974802 0.9931080250211974 0.168477751707855 0.10036210106675972 0.11706883112648013 0.14242807994370554 0.4128525377796211 1.2123885199556214e-07 6.916358184597001 5.127172434700964 up EAVAMESYAK(ub)ALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAVAMESYAKALR 13 1 P78371;F5GWF6;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 1 10918600.0 2336600.0 2955500.0 5626500.0 True False 3200504.1642407225 2824916.2374684676 4297636.581404903 1.0 0.8826472619630669 1.3427998717897187 21.60986775504869 -6.839072254703665 1.2867234120484323 0.9375621671714635 1.3576564253590169 0.9228442643218315 0.054228176945409885 0.1698840935497547 0.5467747425402949 0.033052016272284074 0.07612644179713512 1.448530837649303e-07 6.839072254703665 0.4200942581875534 EAVAMESYAK(ub)ALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAVAMESYAKALR 13 1 P78371;F5GWF6;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 1 13385100.0 4326900.0 3464600.0 5593600.0 True False 3598009.064171107 3445935.5121307406 6763195.898115753 1.0 0.9577339719472329 1.8797050750826354 21.778767390382228 -6.896154716487371 0.985234194938453 0.9575198188371443 1.9692742476635174 0.9845549033288348 0.05281946695967374 0.11429222928546834 0.19380125950810145 0.04048065075639796 0.10343438314431914 1.2701215464967313e-07 6.896154716487371 1.0117544288263731 EAVAMESYAK(ub)ALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAVAMESYAKALR 13 1 P78371;F5GWF6;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 1 66135200.0 5602300.0 8713900.0 51819000.0 True False 7252287.787842771 8228963.804866291 42388473.707840174 1.0 1.1346714368755126 5.8448416482999 22.7900047450758 -6.91301709715961 0.8749455870225161 0.8677094172909325 6.494514959169093 0.9920110302429325 0.20135839302941003 0.10245630290935871 0.1281982546653226 0.16735474684591195 0.472221840946679 1.2217515617121038e-07 6.91301709715961 5.626805541878161 up EAVCIVLSDDTCSDEK(ub)IR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAVCIVLSDDTCSDEKIR 18 1 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 1 90699000.0 43710000.0 27278000.0 19711000.0 True False 66311265.62903743 22410027.77601324 15815112.21036179 1.0 0.33795204424811914 0.2384981203470865 25.982750655008914 -13.999999999999998 0.266913495341809 6.026299721635706 0.2044855345823911 0.9995767356021327 0.006953423814756836 14.734016500652967 0.1635223137725079 40.11126178632973 0.04195246909863169 1.0000000000000041e-14 13.999999999999998 -5.821814187053315 EAVCIVLSDDTCSDEK(ub)IR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAVCIVLSDDTCSDEKIR 18 1 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 1 14244700.0 7053500.0 1077100.0 6114100.0 True False 5865297.773031723 1071297.4485123893 7392530.041595662 1.0 0.18265013814612258 1.260384438721263 22.48377292306321 -6.703942342217202 1.8171771804424708 0.49442255648441186 1.2573880397900592 0.4361636718271883 0.34477163197758204 0.38736405154785647 2.489528602054739 0.15122060191444783 0.3869652739646368 1.9772321238822218e-07 6.703942342217202 0.7629654833056474 EAVCIVLSDDTCSDEK(ub)IR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAVCIVLSDDTCSDEKIR 18 1 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 1 88873000.0 43710000.0 33797000.0 11366000.0 True False 56583456.652911715 31916167.240049306 9297504.625008432 1.0 0.5640547454678512 0.16431489299143046 25.753876977101363 -7.802046069507085 0.3758007484323416 1.061063609482306 2.151858664768417e-21 0.9984442417630661 0.013460892947857359 0.11419370026332963 0.06545807513669304 0.0352950477761231 0.07964220172712787 1.5774439272120862e-08 7.802046069507085 -1.061063609482306 down EAVELPLTHFELYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAVELPLTHFELYK 14 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 10501300.0 4448800.0 1833300.0 4219200.0 False True 4307575.279149999 2565346.250533203 3114064.946713154 1.0 0.5955429874784255 0.7229275740777404 22.038444578521325 -10.784612333228935 10.404821509062026 1.0019560700166912 0.6592352807780836 0.9051363578657202 0.05200453971061624 0.002368077402001263 4.9020889019735814e-05 0.05053128582709776 0.016784393018866577 1.64205487605055e-11 10.784612333228935 -0.3427207892386076 EAVELPLTHFELYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAVELPLTHFELYK 14 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 6927700.0 4448800.0 1153400.0 1325500.0 False True 3699374.3152567497 1147186.405268024 1602655.9215804515 1.0 0.31010281942458834 0.43322350889740163 21.8188498539556 -10.702839908605839 7.887457131059413 1.0028467874206786 0.3716631641686045 0.972009615357212 0.05026381099800816 0.0025208795160187067 9.497405467064764e-05 0.048757758241768465 0.016222575242683564 1.9822575989829698e-11 10.702839908605839 -0.631183623252074 EAVELPLTHFELYK(ub)QIGIDPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAVELPLTHFELYKQIGIDPPR 22 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 12920500.0 4386300.0 4393400.0 4140800.0 True False 4247059.307439228 6147707.531278328 3056200.2586627426 1.0 1.4475209989438786 0.7196038570286611 22.018032824454284 -6.740349607000457 1.6853047863248891 1.266162185558256 0.719134156092561 0.6065703974295413 0.18802786002553895 0.3171778319753887 1.7689690608758448 0.08825541420216504 0.2164971393527229 1.8182365891070752e-07 6.740349607000457 -0.5470280294656951 EAVELPLTHFELYK(ub)QIGIDPPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAVELPLTHFELYKQIGIDPPR 22 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 55798500.0 12854500.0 8778000.0 34166000.0 True False 19501216.28982985 7211497.317172964 27413075.12451025 1.0 0.36979730956237117 1.4057110447416832 24.21706077180608 -6.742053159330019 1.6793580453381673 0.6259257061960504 1.406574697311902 0.6140689441834886 0.26477426580547797 0.31410353803994034 1.7401670818937451 0.12469363163799663 0.30527891286381204 1.811118391131556e-07 6.742053159330019 0.7806489911158516 EAVELPLTHFELYK(ub)QIGIDPPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAVELPLTHFELYKQIGIDPPR 22 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 11753000.0 4386300.0 4274100.0 3092600.0 True False 3647402.796037286 4251074.574957578 3739248.361433204 1.0 1.1655072972955305 1.0251810865242805 21.79843809988856 -10.637762390777446 2.7649928271450577 0.9905029947991058 1.095344192105679 0.3810082577168469 0.05728793785011094 13476732.11774304 12861612.320281934 916049.5327494876 0.020662827711152937 2.3027013163070953e-11 10.637762390777446 0.10484119730657326 EAVELPLTHFELYK(ub)QIGIDPPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAVELPLTHFELYKQIGIDPPR 22 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 60218400.0 12854500.0 16103900.0 31260000.0 True False 16640403.650076747 15207703.808534192 25571000.754686177 1.0 0.9139023384486261 1.5366815188144936 23.988187093898528 -6.871943280203572 1.1236961706146114 0.9506786747020742 1.5745382761962627 0.9665878608579968 0.050365669682633805 0.13500874865889959 0.31742159197584324 0.03474084197920442 0.08254373952709368 1.3429403405913337e-07 6.871943280203572 0.6238596014941885 EAVFK(ub)MLSNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAVFKMLSNK 10 1 Q96S82;H3BSQ2 Q96S82 UBL7 Ubiquitin-like protein 7 1 15975100.0 3845600.0 4906200.0 7223300.0 True False 5041618.840843377 4174214.084217808 6475902.206786239 1.0 0.827951143470325 1.2844886555729649 22.265455620243493 -6.804584050288068 1.4369061419806617 0.9056186432438513 1.2915445257933484 0.8452982936226066 0.07404490141112371 0.2142689499486838 0.8728327504086127 0.04052865900364336 0.0940134104444986 1.5682523598185183e-07 6.804584050288068 0.3859258825494971 EAVFK(ub)MLSNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAVFKMLSNK 10 1 Q96S82;H3BSQ2 Q96S82 UBL7 Ubiquitin-like protein 7 1 17317700.0 3966600.0 3334100.0 10017000.0 True False 3840682.4542070623 4665423.517101811 7393247.196441424 1.0 1.21473815467127 1.9249826781026642 21.872931256786266 -6.949238728070542 0.5671379834121992 0.9910350819921175 2.183048116620211 0.9991401925329145 0.01159032308385899 0.0837928486317743 0.037238384763961664 0.012319704521813699 0.05913648227858072 1.1239869578256165e-07 6.949238728070542 1.1920130346280935 EAVFK(ub)MLSNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAVFKMLSNK 10 1 Q96S82;H3BSQ2 Q96S82 UBL7 Ubiquitin-like protein 7 1 26828200.0 6275100.0 11994000.0 8559100.0 True False 9519785.471259968 9853576.990450287 6867390.133413209 1.0 1.035062924495308 0.7213807657899135 23.182497632034217 -6.879140817138783 1.0845258732662777 1.0214966742304397 0.6995086061896827 0.9729881240723762 0.02306507343408156 0.12839640355755264 0.276878254363141 0.016394624729477177 0.039563069110977324 1.320867282187729e-07 6.879140817138783 -0.32198806804075697 EAVFK(ub)MLSNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAVFKMLSNK 10 1 Q96S82;H3BSQ2 Q96S82 UBL7 Ubiquitin-like protein 7 1 19663400.0 3845600.0 3484800.0 12333000.0 True False 5267422.243432398 3330830.0133074373 9420199.406107996 1.0 0.6323453597175411 1.788388887534775 22.328665681766385 -6.821165528883233 1.3668218826982366 0.802066375600482 1.814263471033952 0.8870431124698628 0.1620827108100805 0.19197150267823834 0.7043912658534905 0.09317845848206244 0.21469766157935555 1.5095047053334628e-07 6.821165528883233 1.01219709543347 EAVFK(ub)MLSNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAVFKMLSNK 10 1 Q96S82;H3BSQ2 Q96S82 UBL7 Ubiquitin-like protein 7 1 15765600.0 3966600.0 5550600.0 6248400.0 True False 3298403.6501747477 5520697.816092166 7554911.550662621 1.0 1.6737483951667598 2.290475136438309 21.653336532220543 -6.972182073434911 0.19929194266853817 0.6295388234205299 3.3516994400796833 0.9999947741582286 0.0012047264190680523 0.07560082055441404 0.006429256926721896 0.0201402695083892 0.06559083631565352 1.0661490556438458e-07 6.972182073434911 2.7221606166591537 EAVFK(ub)MLSNK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 EAVFKMLSNK 10 1 Q96S82;H3BSQ2 Q96S82 UBL7 Ubiquitin-like protein 7 1 42707500.0 8176500.0 15282800.0 19248200.0 True False 10584640.43291083 14432298.745339109 15745225.103210218 1.0 1.3635133698509732 1.4875540839586368 23.33546892510476 -12.267225969030836 0.1743641502382059 1.7298970857340543e-13 1.6020259147843448 0.9994856738670392 0.004692040354642805 6.026588556928748 0.11699060412871573 2.238789702839138 0.09636412398872399 5.404730346690978e-13 12.267225969030836 1.6020259147841718 EAVILPIK(ub)FPHLFTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAVILPIKFPHLFTGK 16 1 O75351;I3L4J1;Q9UN37 O75351;I3L4J1;Q9UN37 VPS4B;VPS4A Vacuolar protein sorting-associated protein 4B;Vacuolar protein sorting-associated protein 4A 1 1499600.0 0.0 0.0 1499600.0 True False 0.0 0.0 1145425.3652314567 0.0 EAVILPIKFPHLFTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAVILPIKFPHLFTGK 16 1 O75351;I3L4J1;Q9UN37 O75351;I3L4J1;Q9UN37 VPS4B;VPS4A Vacuolar protein sorting-associated protein 4B;Vacuolar protein sorting-associated protein 4A 0 6790900.0 0.0 3123100.0 3667800.0 False True 0.0 2657145.653748453 3288291.240021946 0.0 EAVILPIKFPHLFTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAVILPIKFPHLFTGK 16 1 O75351;I3L4J1;Q9UN37 O75351;I3L4J1;Q9UN37 VPS4B;VPS4A Vacuolar protein sorting-associated protein 4B;Vacuolar protein sorting-associated protein 4A 0 23300100.0 0.0 9210000.0 14090100.0 False True 0.0 8803071.746602805 10762308.57471843 0.0 EAVK(ub)HIGYDDSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAVKHIGYDDSSK 13 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 9909000.0 2134600.0 2786400.0 4988000.0 True False 2066838.2914209678 3899024.0508840415 3681493.1632075342 1.0 1.886467880466561 1.7812197395842122 20.978994086635527 -10.251762290691971 5.392340656053832 0.9999230281209327 1.8338438100254566 0.9881923839782212 0.04296737358996414 3.9763921138471765e-05 5.517686784883434e-06 0.041606782708977705 0.013867660195314784 5.600640663918973e-11 10.251762290691971 0.8339207819045239 EAVK(ub)HIGYDDSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAVKHIGYDDSSK 13 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 34902400.0 6122300.0 6320100.0 22460000.0 True False 9287976.700083647 5192228.775833313 18020771.155432288 1.0 0.5590268950380283 1.940225706559965 23.14693292237219 -6.820813528611725 1.368364964471914 0.7625147767078808 1.970905870248289 0.8862470819000281 0.19427587279616798 0.1924220004909382 0.7077405513270262 0.11156346404836441 0.25707986344943395 1.510728670816011e-07 6.820813528611725 1.208391093540408 EAVK(ub)HIGYDDSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAVKHIGYDDSSK 13 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 8112200.0 2364000.0 2406800.0 3341400.0 True False 3238034.6846978865 2300459.617776725 2552230.138293139 1.0 0.7104493440567828 0.7882034588308513 21.626687008693384 -9.883770238090886 6.187592461456386 1.0000000310694621 0.7493264014437541 0.9326974327646422 0.03174298443327039 1.3623173899562099e-08 2.4425634257778324e-09 0.030735016181037956 0.010245004172381611 1.3068620958929365e-10 9.883770238090886 -0.25067362962570805 EAVK(ub)HIGYDDSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAVKHIGYDDSSK 13 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 10278900.0 2134600.0 3843400.0 4300900.0 True False 1775014.4788138533 3822694.8413448315 5200198.304885226 1.0 2.1536133293399007 2.929665288341895 20.759399362069804 -8.197776783969074 0.1757187686962118 1.2732684140569225e-09 4.11917422431994 0.9998675609417865 0.009123633506008567 0.0879891406393752 0.03650916021911871 0.3541221706102965 0.3828778031562154 6.341955874866561e-09 8.197776783969074 4.119174223046671 EAVK(ub)HIGYDDSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAVKHIGYDDSSK 13 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 38730600.0 6122300.0 7468300.0 25140000.0 True False 7925438.038575193 7052682.539836686 20564777.958183356 1.0 0.889879209894699 2.5947812421331373 22.91805924446464 -6.8914799163041325 1.0135573905896698 0.9116174693060585 2.7457585766524426 0.9818297583863358 0.10501242748012682 0.11795176671366385 0.21488530973912312 0.07878460454442565 0.19749287734333773 1.2838671407893274e-07 6.8914799163041325 1.834141107346384 up EAVK(ub)TLGGDPEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAVKTLGGDPEK 12 1 P48200;P48200-2;H0YNL8 P48200 IREB2 Iron-responsive element-binding protein 2 1 12655560.0 769860.0 4370400.0 7515300.0 True False 1167933.9043049836 3590467.9739089445 6029897.660926993 1.0 3.0742047650766398 5.162875774648632 20.155527200879806 -6.971038930482008 0.23203366280444765 0.17186456778163714 8.125041999454217 0.9999893908585945 0.005535522022249375 0.07596700669803114 0.007813389739561291 0.052872402794524084 0.20663620933679666 1.0689590526391763e-07 6.971038930482008 7.95317743167258 EAVK(ub)TLGGDPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAVKTLGGDPEK 12 1 P48200;P48200-2;H0YNL8 P48200 IREB2 Iron-responsive element-binding protein 2 1 7843060.0 769860.0 2690400.0 4382800.0 True False 996598.9462093498 2540676.874948331 3585175.3713256125 1.0 2.5493473423908535 3.5974103574583705 19.926653522972256 -8.180570857180397 0.2064105314561135 1.1553787334462955e-14 4.848313933993472 0.9997556494329523 0.01667826980951625 0.0892166899752353 0.043408285954190724 0.392677196333571 0.4403826904207949 6.598255718461327e-09 8.180570857180397 4.8483139339934604 EAVLLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAVLLLK 7 0 P36578;H3BM89;H3BTP7 P36578 RPL4 60S ribosomal protein L4 0 30061800.0 5465800.0 12005000.0 12591000.0 False True 7165716.730882497 10213900.795123484 11288204.101400398 1.0 1.4253843933160315 1.5753070523637898 22.77267958258695 -11.829906860659987 0.17826282751656242 1.940847101135987e-14 1.7124001047620954 0.9994718025566719 0.005600317980031833 4.899565474843215 0.11341189691605673 1.9521130836449918 0.11206913546637938 1.479425633627938e-12 11.829906860659987 1.712400104762076 EAVLLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAVLLLK 7 0 P36578;H3BM89;H3BTP7 P36578 RPL4 60S ribosomal protein L4 0 19643500.0 8139300.0 3794400.0 7709800.0 False True 7880922.376727569 5309523.707534597 5690372.090957782 1.0 0.6737185641129605 0.722043920615371 22.909933060738712 -10.166002805626272 5.259552447984806 1.0000124086834272 0.6978812423641128 0.9811721271872563 0.019728744178665762 2.870747563044533e-06 4.551851386629234e-07 0.01910305876242574 0.0063674248037245106 6.823342861160951e-11 10.166002805626272 -0.30213116631931447 EAVLLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAVLLLK 7 0 P36578;H3BM89;H3BTP7 P36578 RPL4 60S ribosomal protein L4 0 30257800.0 5465800.0 10840000.0 13952000.0 False True 7486653.967691076 10361052.956913617 10656824.950459654 1.0 1.3839364022468665 1.423442968841563 22.83588964410984 -12.022124156351374 0.3600951556680408 1.213010737472262e-19 1.428638683875006 0.9996410911244554 0.003618154695157482 5.500978640405556 0.1879856871311692 4.145872298420383 0.011390091333621752 9.503330730635175e-13 12.022124156351374 1.428638683875006 EAVLLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAVLLLK 7 0 P36578;H3BM89;H3BTP7 P36578 RPL4 60S ribosomal protein L4 0 13942500.0 8139300.0 3285300.0 2517900.0 False True 6768188.582127604 3267601.436819004 3044381.248545773 1.0 0.4827881784274725 0.44980739109204326 22.69033833617299 -13.999999999999998 0.39134449601201415 9.248152344941147 0.44746780661233476 0.9998251634083463 0.0033314193244107773 25.53435123927435 0.20520072485147128 178.24752093622865 0.00864692923344797 1.0000000000000041e-14 13.999999999999998 -8.800684538328813 EAVLLLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAVLLLKK 8 1 P36578;H3BM89;H3BTP7 P36578 RPL4 60S ribosomal protein L4 1 21253600.0 1737500.0 2911100.0 16605000.0 True False 1682344.0135594173 4073517.4111859463 12255652.360677835 1.0 2.421334387232375 7.284866984338092 20.682041314102225 -6.948461972475258 0.5754808717306985 0.9408257001063379 9.00407370797641 0.9990749962067053 0.08184396649485437 0.084109274806666 0.038564063325050205 0.08617626499171666 0.4057897837498379 1.1259990588707777e-07 6.948461972475258 8.063248007870072 EAVLLLK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAVLLLKK 8 1 P36578;H3BM89;H3BTP7 P36578 RPL4 60S ribosomal protein L4 1 24734300.0 1737500.0 3277800.0 19719000.0 True False 1444808.234301073 3260141.840807644 23842151.729645368 1.0 2.256452976532723 16.501948953231864 20.4624465895365 -6.92422932970046 0.7927295525253187 0.7309592378725382 19.038548287515326 0.9952773796457197 0.48312999621466113 0.0957466500506265 0.09318459269733051 0.42587935990133846 1.3321994984363839 1.1906131373680621e-07 6.92422932970046 18.307589049642786 up EAVLLLK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAVLLLKK 8 1 P36578;H3BM89;H3BTP7 P36578 RPL4 60S ribosomal protein L4 1 31302000.0 1100400.0 3037600.0 27164000.0 True False 1424489.4921268397 2868554.8897349974 22220430.72617709 1.0 2.0137424007614757 15.59887303415681 20.442013548857183 -6.92186337238157 0.8107929774044524 0.7199025734108325 17.886280523029193 0.9946829074977711 0.48533846521168145 0.09708788562161239 0.10002576159793869 0.42234778424037694 1.2885624764197317 1.1971170811776485e-07 6.92186337238157 17.16637794961836 up EAWASK(ub)DATYTSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAWASKDATYTSAR 14 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 78100200.0 25765800.0 31318700.0 21015700.0 True False 33779213.316362135 26646072.03933647 18841196.960829202 1.0 0.7888304499509916 0.5577748890825357 25.009632393836956 -6.969970462268272 0.2588889419780383 1.065755331240502 0.2740048394082113 0.9999821510795248 0.0007629703045506913 0.07631227214387286 0.0090643492522764 0.004858174464027285 0.02183697687373234 1.0715921851093054e-07 6.969970462268272 -0.7917504918322906 EAWASK(ub)DATYTSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAWASKDATYTSAR 14 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 103479400.0 19787400.0 20554000.0 63138000.0 True False 19159259.818075154 28761319.38769399 46600263.70060084 1.0 1.5011706955693611 2.432258038310927 24.191538490556017 -6.961460989978564 0.41432956680517957 0.9562436156945562 3.0119835864550843 0.9998206049783277 0.007948338953879627 0.07918329670695572 0.019233019414401215 0.01200784892417901 0.07763342062233779 1.0927957819528251e-07 6.961460989978564 2.055739970760528 EAWASK(ub)DATYTSAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAWASKDATYTSAR 14 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 378469600.0 43416000.0 37120600.0 297933000.0 True False 65865246.13475839 30496138.90542842 239046411.96132725 1.0 0.463008045897744 3.629325418024632 25.97301409067828 -6.863256322255531 1.1692714392596448 0.7057627932230919 3.79239598796285 0.9574714141161413 0.28531693503659666 0.14347932104004812 0.37093275066013853 0.1900604788409911 0.4453832287607927 1.3700729052506955e-07 6.863256322255531 3.0866331947397585 up EAWASK(ub)DATYTSAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAWASKDATYTSAR 14 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 53579100.0 25765800.0 18081100.0 9732200.0 True False 35292112.55456377 17282217.215798065 7433654.800950643 1.0 0.4896906409067663 0.21063218557567948 25.072842455359847 -8.882593450535028 0.23930913620604852 1.310581228549298 4.493278174612548e-19 0.9993037330264254 0.008624154514782309 0.3804959140769131 0.0760511141725137 0.215245511319333 0.1178610777436897 1.310408041295904e-09 8.882593450535028 -1.310581228549298 EAWASK(ub)DATYTSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAWASKDATYTSAR 14 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 113664400.0 19787400.0 49687000.0 44190000.0 True False 16454099.830451237 49419326.26890265 53429924.68852519 1.0 3.00346580962414 3.247210436249063 23.971943765990293 -10.236171984095447 0.45963036855228756 3.5609722934989195e-21 3.2502953786692355 0.9993014803755368 0.02660986217229773 1.5762341729539566 0.21301782391323223 2.0679175881652343 0.05358731696406596 5.8053447568989886e-11 10.236171984095447 3.2502953786692355 EAWASK(ub)DATYTSAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAWASKDATYTSAR 14 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 394456000.0 43416000.0 40282000.0 310758000.0 True False 56202867.85730531 38040271.289276175 254203232.64634567 1.0 0.6768386158844679 4.522958388738237 25.74414041277073 -6.886488494491758 1.0428940085711378 0.7756153896520596 4.83191261883355 0.9785553298410428 0.25508552443152793 0.12204008563785432 0.23884176097193807 0.18716770023732174 0.4611024941627241 1.298707969279706e-07 6.886488494491758 4.0562972291814905 up EAYALCHCLPVLSTDK(ub)FK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAYALCHCLPVLSTDKFK 18 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 74371000.0 12287000.0 21129000.0 40955000.0 True False 18640277.300022483 17358364.86836951 32860226.298785828 1.0 0.9312288969192841 1.762861451570047 24.151919986456495 -6.886834881071751 1.0408969745635293 0.9518665419699087 1.8301137151376263 0.9787949392918108 0.05488009538337741 0.1217499193614476 0.2371357106380537 0.040329409266844835 0.09946434413392184 1.2976725528063157e-07 6.886834881071751 0.8782471731677176 EAYALCHCLPVLSTDK(ub)FK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAYALCHCLPVLSTDKFK 18 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 34677400.0 4066300.0 6985100.0 23626000.0 True False 5569720.99762564 6676475.185363232 18046025.39274365 1.0 1.1987090894156816 3.240023225658275 22.40917363020667 -6.925760336330736 0.780809195360206 0.9636004290686623 3.6171716713872932 0.9956373659855976 0.06686769878813359 0.09489961392270535 0.08890856638381195 0.05944789803996835 0.18919149458738238 1.1864232904851543e-07 6.925760336330736 2.653571242318631 up EAYALCHCLPVLSTDK(ub)FK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAYALCHCLPVLSTDKFK 18 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 89914000.0 12287000.0 31051000.0 46576000.0 True False 15905763.71297932 29322984.55397733 38099645.91011721 1.0 1.8435445844105791 2.3953358416249686 23.923046308548944 -8.379580006699333 0.14819678640009532 4.631466967745657e-20 3.4502006983686395 0.9999142340351321 0.005313761229798199 0.11100306298859196 0.034463782740134855 0.37104400787952274 0.34928057896934334 4.172727204717877e-09 8.379580006699333 3.4502006983686395 EAYFEK(ub)QQQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAYFEKQQQK 10 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A0A0MS38;G3V2G1;G3V2G2;G3V3T6;P54252-5 P54252-1 ATXN3 Ataxin-3 1 31442700.0 12711000.0 13424100.0 5307600.0 True False 16664244.093499115 11421276.606731964 4758420.466094251 1.0 0.6853762188461652 0.28554673343692544 23.990252541078007 -7.196129007667353 0.34577259769966523 1.047845910948858 1.8022901017157116e-12 0.9998474705531605 0.0036107843571145898 0.0886071131101792 0.019795411670441895 0.008848992423129974 0.041518031760592246 6.366063881701879e-08 7.196129007667353 -1.0478459109470557 down EAYFEK(ub)QQQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAYFEKQQQK 10 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A0A0MS38;G3V2G1;G3V2G2;G3V3T6;P54252-5 P54252-1 ATXN3 Ataxin-3 1 39537200.0 9139600.0 17207400.0 13190200.0 True False 8849468.40076411 24078404.555405546 9735290.922481954 1.0 2.7208871160358616 1.1000989530220096 23.077159362529265 -6.632062012449793 2.07256165835105 2.1320654870558626 1.1066375762986567 0.12492769331716913 0.7377916012990714 0.5538103970241096 4.53593426944203 0.2908520542218023 0.8174152609225223 2.3331248940589207e-07 6.632062012449793 -1.025427910757206 EAYFEK(ub)QQQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAYFEKQQQK 10 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A0A0MS38;G3V2G1;G3V2G2;G3V3T6;P54252-5 P54252-1 ATXN3 Ataxin-3 1 30086700.0 16704500.0 7439100.0 5943100.0 True False 25341947.762531575 6111534.483046416 4768443.68004673 1.0 0.2411627764493464 0.18816405608320844 24.595024077378266 -13.74151354245564 0.38019648012115614 9.999999371285806 0.1834643697243298 0.9998020160656148 0.005218007854605906 19.635545405597707 0.2006844930020954 143.48892775655432 0.014362188516298889 1.813370129291357e-14 13.74151354245564 -9.816535001561476 EAYFEK(ub)QQQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAYFEKQQQK 10 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A0A0MS38;G3V2G1;G3V2G2;G3V3T6;P54252-5 P54252-1 ATXN3 Ataxin-3 1 29001500.0 12711000.0 11142600.0 5147900.0 True False 17410600.20185907 10650283.088349245 3932072.0443284954 1.0 0.6117125753776155 0.2258435664905243 24.0534626026009 -7.592359893107362 0.3403599182228695 1.0679704354852209 1.4808807711383716e-20 0.9993279353493382 0.008193306984320478 0.12406576191126359 0.04332401217535753 0.02530837728878238 0.07115880239146138 2.5564665046996803e-08 7.592359893107362 -1.0679704354852209 down EAYFEK(ub)QQQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAYFEKQQQK 10 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A0A0MS38;G3V2G1;G3V2G2;G3V3T6;P54252-5 P54252-1 ATXN3 Ataxin-3 1 39677200.0 9139600.0 21895600.0 8642000.0 True False 7599982.3529312685 21777644.056863707 10449002.243906653 1.0 2.865486134775589 1.374871908732332 22.85756463796354 -6.590206268522787 2.2279514882643787 2.2624398422850214 1.3792034601307122 0.0 0.808336836079798 0.6690054764015859 6.260765358526416 0.3028370234450219 0.9010030750830124 2.569175261036246e-07 6.590206268522787 -0.8832363821543092 EAYFEK(ub)QQQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAYFEKQQQK 10 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A0A0MS38;G3V2G1;G3V2G2;G3V3T6;P54252-5 P54252-1 ATXN3 Ataxin-3 1 33501400.0 16704500.0 11714800.0 5082100.0 True False 21624304.54492252 11062861.081863169 4157209.946749545 1.0 0.5115938438103794 0.19224710501617848 24.366150399470715 -8.32480136124366 0.28751006681801555 1.1691305719154006 4.680875281056694e-21 0.9990547824814505 0.010212133442223378 0.10939033529864575 0.07017712757403939 0.0978348211436799 0.09866700210499736 4.7336771963196676e-09 8.32480136124366 -1.1691305719154006 down EAYMGNVLQGGEGQAPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAYMGNVLQGGEGQAPTR 18 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;H0YEL7;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 26017000.0 2677000.0 12930000.0 10410000.0 False True 3509572.9241048787 11000894.400745247 9332873.059771119 1.0 3.134539341008576 2.659261756799506 21.742864050633738 -10.080769028581832 5.306326817655969 0.9999748639486487 2.896900548906052 0.9550338635270584 0.19403126125618997 5.7699747862541735e-05 9.995682686700358e-06 0.18787243138951457 0.06262332028972052 8.302922255439486e-11 10.080769028581832 1.8969256849574037 EAYMGNVLQGGEGQAPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAYMGNVLQGGEGQAPTR 18 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;H0YEL7;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 17392300.0 4378500.0 2369800.0 10644000.0 False True 4239506.914169728 3316073.4983437415 7856017.08684462 1.0 0.7821837693578021 1.8530497168402793 22.015465047827416 -6.853740701423174 1.2169271707915272 0.8832824361990709 1.8990436919003646 0.9455702830698439 0.10781054157240218 0.1533907628603678 0.4352559877246448 0.0692514490416856 0.1606808710974541 1.400423205543418e-07 6.853740701423174 1.0157612557012938 EAYMGNVLQGGEGQAPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAYMGNVLQGGEGQAPTR 18 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;H0YEL7;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 25291300.0 2677000.0 13018000.0 9596300.0 False True 3666759.24320484 12442821.715230769 7329851.582002281 1.0 3.3934111540836884 1.9989999604107649 21.80607411215663 -10.193309657256746 5.990580443618338 0.999975057793064 2.6962055572472408 0.6636326850752992 0.5692659860206959 0.00018963878203921407 2.553785419958783e-05 0.5511974611414623 0.18372980695170105 6.407525492973687e-11 10.193309657256746 1.6962304994541768 EAYNLFAVNGILFNHESPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAYNLFAVNGILFNHESPR 19 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 3543280.0 1295900.0 1399700.0 847680.0 False True 1698937.44951345 1190870.2159878658 759970.2051207284 1.0 0.7009500063283159 0.4473208859680928 20.696201306520848 -7.17419097639022 0.18718112660898997 1.1921769390879646 1.329927400760218e-12 0.9999923624669832 0.00062422869493531 0.08698705396486114 0.008152183115536749 0.013686715663039986 0.03513864640714254 6.695900995260702e-08 7.17419097639022 -1.1921769390866348 down EAYNLFAVNGILFNHESPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAYNLFAVNGILFNHESPR 19 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 7859100.0 2988200.0 1709100.0 3161800.0 False True 2893341.2266579797 2391552.542838756 2333629.728033196 1.0 0.8265712045313002 0.806551853107457 21.464305047094705 -13.999999999999998 0.30471034530181984 2.6255665520814047 0.8018623711740261 0.9996603082957574 0.0016008657055849736 16.901624845124722 0.17545198658017933 17.36843733116945 0.007091302980739909 1.0000000000000041e-14 13.999999999999998 -1.8237041809073786 EAYNLFAVNGILFNHESPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAYNLFAVNGILFNHESPR 19 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 7597500.0 1295900.0 3170000.0 3131600.0 False True 1775029.2503807042 3029938.9182118294 2391980.5773265054 1.0 1.7069797117776933 1.3475724846863673 20.75941136804374 -10.048617836030969 4.331972936923567 0.9999614013351391 1.527276097979128 0.7415841502503202 0.14672738632960214 16730039.877487108 7770683.441808012 5975.133752330777 0.0502286884042322 8.940919073071388e-11 10.048617836030969 0.5273146966439889 EAYNQGLK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAYNQGLKK 9 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 1 3141940.0 632240.0 1379900.0 1129800.0 True False 828872.762620869 1174024.2988080727 1012899.1338068601 1.0 1.4164107589877193 1.2220200487757682 19.66079113004884 -10.099952307143026 4.393402879010962 0.9999677043954506 1.319215403716935 0.7823942960181282 0.07935967522465623 11899092.391097026 13677357.032050861 3263.842597572324 0.02716692915518352 7.944154701479013e-11 10.099952307143026 0.31924769932148445 EAYNQGLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAYNQGLKK 9 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 1 2614990.0 552590.0 1049400.0 1013000.0 True False 535048.3329224739 1468430.8925487045 747664.91065141 1.0 2.7444826984658106 1.397378264067488 19.02930969589078 -6.580937001776666 2.263809029450429 2.1873118337320596 1.4008167248427763 0.0 0.7576863891362835 0.6965275517741855 6.715767830731136 0.28091702929858176 0.8464813660095214 2.62459923690918e-07 6.580937001776666 -0.7864951088892833 EAYNQGLK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAYNQGLKK 9 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 1 2226940.0 632240.0 711150.0 883550.0 True False 865996.2136435657 679729.0415414325 674873.6872834456 1.0 0.7849099462936004 0.7793032771402116 19.72400119157173 EAYNQGLK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAYNQGLKK 9 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 1 2095050.0 552590.0 1055800.0 486660.0 True False 459503.0688877295 1050112.1958401096 588418.3559383957 1.0 2.285321398139963 1.2805537019866218 18.809714971325057 -10.228690661302581 4.869087353244344 0.9998625468914747 1.7829375500645956 0.44738665324937954 0.4101946942724139 0.0006121653370674543 9.697389659831284e-05 0.3972380681533581 0.13238976830100097 5.906216175663758e-11 10.228690661302581 0.783075003173121 EAYPGDVFYLHSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EAYPGDVFYLHSR 13 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 63202000.0 15477000.0 22341000.0 25384000.0 False True 20290496.879481178 19007809.884535935 22757507.1805216 1.0 0.9367838548970003 1.1215845188855476 24.274300858866788 -6.814354938552138 1.395967013856258 0.9657207921729639 1.1251558265124935 0.8709480152816297 0.027549486707970566 0.20091262858445333 0.770758421125419 0.015513533621057833 0.035823619350071056 1.533363289210614e-07 6.814354938552138 0.15943503433952955 EAYPGDVFYLHSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EAYPGDVFYLHSR 13 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 43235500.0 13594000.0 4963500.0 24678000.0 False True 13162465.910979398 6945451.434310564 18214091.475869186 1.0 0.5276709912325056 1.3837902106683524 23.64992645908079 -6.756911367072056 1.6239226584497495 0.7245983395206405 1.3864692336762388 0.6783142917368257 0.19858538813843551 0.28813037773582734 1.4967952194577807 0.09651640298636512 0.23267308891001032 1.7502038422823205e-07 6.756911367072056 0.6618708941555983 EAYPGDVFYLHSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EAYPGDVFYLHSR 13 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 119854000.0 12773000.0 96890000.0 10191000.0 False True 19377574.831381746 79599222.49497478 8176744.383126019 1.0 4.107801063219986 0.4219694391211371 24.207884688129045 -6.683205237254595 1.8907155957395436 2.960736742228666 0.43574855873586693 0.33866401678655733 1.3162621613386867 0.43150087205951554 2.9850834552532004 0.5580803059621335 1.4657665109750473 2.0739331942773375e-07 6.683205237254595 -2.524988183492799 EAYPGDVFYLHSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EAYPGDVFYLHSR 13 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 58777000.0 15477000.0 19349000.0 23951000.0 False True 21199265.150198434 18494097.201413456 18294267.086328793 1.0 0.8723933150692417 0.8629670395040817 24.33751092038968 -13.999999999999806 0.36969950417328307 2.7741068339311874 0.8619852038631616 0.9997903781772481 0.0009048008450799278 22.78494637204323 0.1973332050310713 32.031565247728224 0.0026369738893214207 1.0000000000004459e-14 13.999999999999806 -1.9121216300680257 EAYPGDVFYLHSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EAYPGDVFYLHSR 13 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 27556500.0 13594000.0 6992600.0 6969900.0 False True 11304013.316310085 6954929.475877572 8427273.864823531 1.0 0.6152619676980208 0.7455116717408827 23.430331734515065 -10.36374305896479 4.993817980892719 1.000212458116949 0.6803868197193926 0.8892396732758119 0.0531742190091275 0.00012586209239238156 1.6035830992974676e-05 0.051519629740233525 0.017161905389132058 4.327697942963696e-11 10.36374305896479 -0.3198256383975563 EAYPGDVFYLHSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EAYPGDVFYLHSR 13 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 41313000.0 12773000.0 20040000.0 8500000.0 False True 16534900.293471565 18924756.383424222 6953087.217365088 1.0 1.1445340490439024 0.4205097759259158 23.979011010221495 -6.854806508388864 1.2116650158296307 1.0775730621547432 0.3887669579146689 0.947011565485021 0.07201701187910264 0.15224978202612344 0.4277242403065067 0.04644473086700618 0.10786036932199684 1.3969906249163566e-07 6.854806508388864 -0.6888061042400744 down ECCSQCK(ub)ILER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ECCSQCKILER 11 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;A0A0A0MRS6;Q86UV5-5 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 39836900.0 10709000.0 10366000.0 18761900.0 True False 14039602.706103515 8819433.206351522 16820598.56485301 1.0 0.6281825341480212 1.1980822333056829 23.7429987749221 -6.730629357893359 1.7207514802579222 0.7764032084176148 1.1977946020328065 0.5622788197618189 0.1562954542167497 0.3350514483542053 1.9438331758468745 0.07196787329249725 0.17846882781944942 1.859390647177123e-07 6.730629357893359 0.42139139361519173 ECCSQCK(ub)ILER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ECCSQCKILER 11 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;A0A0A0MRS6;Q86UV5-5 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 137618600.0 21130500.0 50228900.0 66259200.0 True False 32056513.346473917 41265160.354813114 53163040.07756092 1.0 1.287262900640818 1.6584161696864212 24.934114182302338 -6.967618643916537 0.3098350569926778 0.9427092710699806 2.0147648376272325 0.99995739708948 0.0017591952388980256 0.07708324362688393 0.011782101366172493 0.005876771232399761 0.03295659698366207 1.0774108780718714e-07 6.967618643916537 1.072055566557252 ECCSQCK(ub)ILER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ECCSQCKILER 11 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;A0A0A0MRS6;Q86UV5-5 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 38287200.0 10709000.0 8195100.0 19383100.0 True False 14668406.699843328 7833013.384428315 14805210.987475224 1.0 0.5340057406856586 1.0093264585875819 23.80620883644499 -10.874868863869974 11.082906169209727 1.009370304597623 0.771666099637006 0.2352897256052845 0.19404887050551625 0.04424584666613386 0.0004995550410525444 0.18503274191440902 0.06262900365151867 1.3339241525557688e-11 10.874868863869974 -0.23770420496061695 ECCSQCK(ub)ILER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ECCSQCKILER 11 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;A0A0A0MRS6;Q86UV5-5 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 109487100.0 21130500.0 52812100.0 35544500.0 True False 27353848.794425774 49873060.20943305 29075765.71736865 1.0 1.8232556809188873 1.062949712703456 24.705240504394787 -10.228112734633573 4.59823942749678 0.9998784740001803 1.4431026968110892 0.3117057753560336 0.3103936117704777 218801384.49767762 64.50367404183632 289758.32052163646 0.1062559892925042 5.914080958922866e-11 10.228112734633573 0.4432242228109089 ECEIK(ub)YTGFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ECEIKYTGFR 10 1 Q13951-2;A0A494C0A9;Q13951;H3BSC0;J3KTD8;J3KRT0 Q13951-2 CBFB Core-binding factor subunit beta 1 40320900.0 4105700.0 9417600.0 26797600.0 True False 6228647.066875756 7736955.699955349 21501042.614194654 1.0 1.2421567022316693 3.4519603347793186 22.570487396798516 -6.927733089323151 0.7651719034034694 0.9634190597409525 3.8804965459643608 0.9960736539073032 0.06912880244867377 0.09383201866100571 0.08357301626073312 0.0621504945247292 0.20249854927287753 1.1810462654309258e-07 6.927733089323151 2.917077486223408 up ECEIK(ub)YTGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ECEIKYTGFR 10 1 Q13951-2;A0A494C0A9;Q13951;H3BSC0;J3KTD8;J3KRT0 Q13951-2 CBFB Core-binding factor subunit beta 1 29881700.0 4105700.0 5750000.0 20026000.0 True False 5314909.585446349 5430007.445343771 16381473.484112142 1.0 1.0216556571747881 3.0821735009319853 22.341613718890965 -6.909197753341006 0.9011792190047836 0.9345723135505304 3.3439427876088357 0.990615324366826 0.09459621452202431 0.10495094825414258 0.14166198851451908 0.07714129509891837 0.21178004885226387 1.2325434742864742e-07 6.909197753341006 2.4093704740583055 up ECGLWLSLGGFHER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ECGLWLSLGGFHER 14 0 Q86X76-2;Q86X76-4;Q86X76;Q86X76-3;Q86X76-5 Q86X76-2 NIT1 Nitrilase homolog 1 0 6736900.0 2150800.0 2678500.0 1907600.0 False True 2819719.628376829 2278878.2407112257 1710219.8509912952 1.0 0.8081932039544873 0.6065212419632596 21.427120288381065 -6.970492082109117 0.2461569617305741 1.0671043803350142 0.34173207651342685 0.9999859670408248 0.000601791163008558 0.07614341993096996 0.008457208148444155 0.004617753630445296 0.019452121144118567 1.0703058961412282e-07 6.970492082109117 -0.7253723038215873 ECGLWLSLGGFHER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ECGLWLSLGGFHER 14 0 Q86X76-2;Q86X76-4;Q86X76;Q86X76-3;Q86X76-5 Q86X76-2 NIT1 Nitrilase homolog 1 0 86335000.0 22318000.0 33501000.0 30516000.0 False True 33858037.66435277 27522484.80549233 24484499.224362068 1.0 0.812878911599452 0.7231517510579305 25.01299502451107 -13.999999999624542 0.09726706219783775 1.9319982107538891 0.5236796484762924 0.9998073248875866 0.0016008636477786676 12.101848064910152 0.09231501013157739 2.280457560578728 0.17820401394999671 1.0000000008645237e-14 13.999999999624542 -1.4083185622775967 ECGLWLSLGGFHER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ECGLWLSLGGFHER 14 0 Q86X76-2;Q86X76-4;Q86X76;Q86X76-3;Q86X76-5 Q86X76-2 NIT1 Nitrilase homolog 1 0 18891600.0 2150800.0 7534600.0 9206200.0 False True 2946008.8831845224 7201696.458409719 7031885.167640603 1.0 2.444560333648744 2.386919200338393 21.490330349903957 -10.117686617081805 5.045073902816715 0.9999499223216983 2.4157397669970146 0.9987582909475652 0.023531894146318687 1.3255291815897307e-05 2.3182051557748728e-06 0.022785456626691774 0.00759488617606921 7.626291177076895e-11 10.117686617081805 1.4157898446753163 ECGLWLSLGGFHER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ECGLWLSLGGFHER 14 0 Q86X76-2;Q86X76-4;Q86X76;Q86X76-3;Q86X76-5 Q86X76-2 NIT1 Nitrilase homolog 1 0 66991000.0 22318000.0 23996000.0 20677000.0 False True 28891090.953550342 22660601.50582076 16913998.163936228 1.0 0.7843456497455684 0.5854399264856323 24.78412134660352 -6.9720944327095085 0.20199352939849333 1.115390408747732 0.2488915019926039 0.999994438883528 0.0003991770234587686 0.07562879452541078 0.006538169521312116 0.006353107147058981 0.021010993884771192 1.0663642264762286e-07 6.9720944327095085 -0.8664989067551281 ECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDK ddPTM_RPMI8226_Bortezomib_8h_R1 2 ECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDK 38 0 F8VVB9;F8VS66;F8W0F6;P68363;P68363-2;Q71U36;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 1591404600.0 503771600.0 554438000.0 533195000.0 False True 764258347.8372267 455494207.05613416 427808774.5423297 1.0 0.5959950693965416 0.5597698419035723 29.509485164559322 -13.999999999999998 0.34134769864024467 5.711340521580998 0.5541763939815831 0.999737883216378 0.0032305017949830934 19.82829841651077 0.1874980019522551 67.45298638717587 0.011138788080421819 1.0000000000000041e-14 13.999999999999998 -5.1571641275994144 ECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDK 38 0 F8VVB9;F8VS66;F8W0F6;P68363;P68363-2;Q71U36;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 788693600.0 503771600.0 39770000.0 245152000.0 False True 652142267.0228317 37556764.5393603 200536851.4719398 1.0 0.05758983344357502 0.30750476025336193 29.28061148665177 -10.529591139485188 5.82293410298488 1.001490399986797 0.18254729684846852 0.9344917693705779 0.10202734163149758 0.001976877369039733 0.000159702816865606 0.0989279165126549 0.03292918291638363 2.9539889098910906e-11 10.529591139485188 -0.8189431031383285 ECK(ub)VANYCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ECKVANYCR 9 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 18631000.0 3780000.0 5669300.0 9181700.0 True False 4955616.605572073 4823462.538758313 8231665.76108553 1.0 0.9733324675147053 1.661078008300699 22.240633146101395 -6.8978804750799805 0.9745868889020285 0.9697184215710953 1.7302356260776064 0.9854810770378274 0.03833015505315697 0.11298263926856543 0.18635830279590354 0.029611382755216596 0.07625489945845977 1.2650844714305086e-07 6.8978804750799805 0.7605172045065111 ECK(ub)VANYCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ECKVANYCR 9 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 33162900.0 5592500.0 9614400.0 17956000.0 True False 8484231.366515491 7898635.202349937 14406988.72960563 1.0 0.9309782891498324 1.6980900339971092 23.016352533282365 -6.884932975283401 1.051861732916147 0.9536380452830119 1.7578807134549028 0.977453170106312 0.052028912548458504 0.12335200177226927 0.24661921325513056 0.037916402689969333 0.09295922249822285 1.303367911848942e-07 6.884932975283401 0.8042426681718909 ECK(ub)VANYCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ECKVANYCR 9 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 16754200.0 3780000.0 3961600.0 9012600.0 True False 5177568.150659055 3786563.4127406892 6884009.5003234325 1.0 0.7313401393391018 1.3295835612414224 22.303843207624286 -6.784615784061919 1.5177814561109673 0.8487896765796926 1.3350358637584847 0.7834154708037513 0.11385848444095917 0.2434681646488747 1.1080212555344369 0.059066789814925434 0.1388511698411771 1.6420418286026744e-07 6.784615784061919 0.4862461871787921 ECK(ub)VANYCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ECKVANYCR 9 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 30614500.0 5592500.0 7723000.0 17299000.0 True False 7239601.494655892 7293208.260937393 14150759.502729243 1.0 1.0074046570548216 1.9546323804114092 22.787478855374815 -6.90861519698047 0.9051245520242133 0.9693690540834415 2.0734825411339557 0.9903874977222882 0.043951167329980986 0.10534245089821923 0.14379400906285714 0.03573827645741031 0.0977310945985498 1.234197899707043e-07 6.90861519698047 1.104113487050514 ECLPLIIFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ECLPLIIFLR 10 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 320635000.0 143540000.0 128650000.0 48445000.0 False True 188182330.04333735 109455921.47377238 43432376.11725377 1.0 0.5816482421519878 0.23079943854054488 27.487555927252203 -7.813177145249607 0.3043065389471488 1.106141566706053 1.9763045952989987e-13 0.9993468295049036 0.008035887757972668 0.11730261691511057 0.04895182342157272 0.04240441839071735 0.08306532476520208 1.5375273672520428e-08 7.813177145249607 -1.1061415667058554 down ECLPLIIFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ECLPLIIFLR 10 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 659170000.0 143540000.0 194350000.0 321280000.0 False True 196610617.02264565 185762974.37049487 245400280.9693001 1.0 0.9448267707185857 1.2481537603894242 27.550765988775094 -6.859804172541394 1.1867276234578252 0.9700804818217177 1.262786986765784 0.9533985573323616 0.028478568844761673 0.14700771288528092 0.3935160495098023 0.01871831167541768 0.04368445441615041 1.381006833175899e-07 6.859804172541394 0.29270650494406625 ECPSDECGAGVFMASHFDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ECPSDECGAGVFMASHFDR 19 0 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 0 77814000.0 16603000.0 26157000.0 35054000.0 False True 21766693.783680715 22254477.559187416 31426948.341711506 1.0 1.0224096401756895 1.4438089980056337 24.375618952577124 -6.917899276590087 0.8401473256920696 0.9899795894380736 1.5085877259883762 0.9935774555603845 0.016359671092982093 0.09942389166442214 0.11213135031790349 0.01394092011181733 0.04095745664692404 1.2080939888769936e-07 6.917899276590087 0.5186081365503026 ECPSDECGAGVFMASHFDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ECPSDECGAGVFMASHFDR 19 0 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 0 74565000.0 16603000.0 23726000.0 34236000.0 False True 22741577.779204305 22677706.868610043 26150161.912552793 1.0 0.9971914476992592 1.1498833619391797 24.438829014100016 -6.902711028793254 0.9439691657941686 0.9941151687700058 1.1668234692775241 0.9878674842911952 0.007856491068341806 0.10943720098603578 0.16637871753445058 0.00620888154061217 0.016385667265340492 1.251091205388634e-07 6.902711028793254 0.1727083005075183 ECSIYLIGGSIPEEDAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ECSIYLIGGSIPEEDAGK 18 0 Q9NQR4;H7C579 Q9NQR4 NIT2 Omega-amidase NIT2 0 5685200.0 1617600.0 1896300.0 2171300.0 False True 2120689.2648606817 1613379.4317195052 1946634.7045803107 1.0 0.7607806850597209 0.9179254767945433 21.01610181400861 -10.215763597079052 4.493952326978694 1.000048034277991 0.8393530809250035 0.582188678294576 0.06415409258827527 14647186.037868306 33296350.836180266 4392.195428545734 0.02196165042727078 6.084661222854566e-11 10.215763597079052 -0.16069495335298745 ECSIYLIGGSIPEEDAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ECSIYLIGGSIPEEDAGK 18 0 Q9NQR4;H7C579 Q9NQR4 NIT2 Omega-amidase NIT2 0 5343300.0 1617600.0 1319100.0 2406600.0 False True 2215670.433996317 1260817.800319628 1838210.6454828132 1.0 0.56904573034607 0.8296408244105625 21.079311875531502 -10.33019251842223 5.827307523103551 1.00003757480562 0.6993432773783156 0.6396129665088289 0.10638750165510188 5.194111232334525e-05 5.970308328803585e-06 0.10302210237335165 0.03433641851290148 4.6752784490303306e-11 10.33019251842223 -0.30069429742730447 ECVLPGGETAGDMGK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ECVLPGGETAGDMGKLR 17 1 A0A2R8YFH0;E9PHA6;A0A2R8Y6P0;A0A2R8YG02;P43246;P43246-2;A0A2R8Y7S8 A0A2R8YFH0 MSH2 DNA mismatch repair protein Msh2 1 11443800.0 2604700.0 4013800.0 4825300.0 True False 3414786.9239506833 3414956.6856698603 4326024.2435459765 1.0 1.0000497137077533 1.2668504184562859 21.703364129288975 -6.906931923846901 0.9163501387259055 0.9909164421958991 1.2991622501957834 0.9897118595590467 0.012758205082815971 0.10648293253350075 0.150021945348366 0.010289362523731145 0.02783514761128032 1.2389907845217102e-07 6.906931923846901 0.3082458079998842 ECVLPGGETAGDMGK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ECVLPGGETAGDMGKLR 17 1 A0A2R8YFH0;E9PHA6;A0A2R8Y6P0;A0A2R8YG02;P43246;P43246-2;A0A2R8Y7S8 A0A2R8YFH0 MSH2 DNA mismatch repair protein Msh2 1 39230000.0 0.0 0.0 39230000.0 True False 0.0 0.0 31476173.30488018 0.0 EDAANNYAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDAANNYAR 9 0 A6NHL2-2;A6NHL2;F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;P68363;P68363-2;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 A6NHL2-2;F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA1C;TUBA1A;TUBA4A Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 39038230.0 648230.0 21688000.0 16702000.0 False True 849835.8074682498 18452234.939161863 14973837.25689695 1.0 21.71270588624997 17.619682679064308 19.69682460670714 -9.589906826706919 8.678516594652356 1.0000754355011146 19.66619428265717 0.9651941073692769 1.670969727730173 0.0 0.0 1.6179092405533273 0.5393031605408024 2.5709472931879114e-10 9.589906826706919 18.666118847156056 EDAANNYAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDAANNYAR 9 0 A6NHL2-2;A6NHL2;F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;P68363;P68363-2;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 A6NHL2-2;F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA1C;TUBA1A;TUBA4A Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 17669300.0 5355300.0 2560300.0 9753700.0 False True 5185298.932843012 3582641.1417881204 7198913.36527212 1.0 0.6909227776813667 1.3883314074093462 22.305995732229327 -6.7862409296037445 1.511375361109225 0.8264066884282263 1.3949932050834069 0.788884725503102 0.1311004792445846 0.24100914028839449 1.0876211846669799 0.0682927835866771 0.16033500300973283 1.6359087314247482e-07 6.7862409296037445 0.5685865166551806 EDAANNYAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDAANNYAR 9 0 A6NHL2-2;A6NHL2;F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;P68363;P68363-2;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 A6NHL2-2;F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA1C;TUBA1A;TUBA4A Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 26735230.0 648230.0 13077000.0 13010000.0 False True 887898.1487570684 12499214.90014385 9937305.94936068 1.0 14.077307084873395 11.191943539100176 19.76003466823003 -9.68554377043491 10.543144456416343 1.0000000000015075 12.63462531198183 0.9559066569376931 1.1779447349286665 0.0 0.0 1.1405400852828593 0.38018002842761967 2.062795757651994e-10 9.68554377043491 11.634625311980322 EDAGAEK(ub)IFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDAGAEKIFR 10 1 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 1 16006900.0 2207300.0 3416600.0 10383000.0 True False 2857393.362387831 3226463.2065672204 8493400.538576683 1.0 1.1291631208490558 2.972429575282216 21.446268227545218 -6.921045256050175 0.8169363998354738 0.9608415033152075 3.2769393905618984 0.9944663786107827 0.06701737517681756 0.09756072340562243 0.10245580476920498 0.05806416639687229 0.17570654043171777 1.1993743147495244e-07 6.921045256050175 2.316097887246691 up EDAVSK(ub)EVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDAVSKEVTR 10 1 Q9UNL2-2;C9JA28;Q9UNL2;C9J365 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 62941900.0 3657500.0 2830400.0 56454000.0 True False 4795017.919280388 2408115.3528127903 50612681.62500653 1.0 0.5022119611127934 10.555264334153357 22.19310477601881 -6.895250280997698 0.9907773101206434 0.525840373665702 11.514471502869515 0.9840523942355599 0.5842130320325585 0.11498755305665136 0.197777690827657 0.4458807311856602 1.134824558141265 1.272769381164185e-07 6.895250280997698 10.988631129203814 up EDAVSK(ub)EVTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDAVSKEVTR 10 1 Q9UNL2-2;C9JA28;Q9UNL2;C9J365 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 221711400.0 2617400.0 67674000.0 151420000.0 True False 3970787.15757133 55597045.960624605 121491770.63025628 1.0 14.001517521435137 30.596394570935608 21.920993600812118 -7.255624894913764 0.3802020536031142 1.5397162968482315e-13 40.39341991944051 0.9992435105421108 0.33314169562745266 0.13308455176183961 0.036946983578145985 0.5604073438796467 2.5663839470115337 5.551049564319916e-08 7.255624894913764 40.393419919440355 EDAVSK(ub)EVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDAVSKEVTR 10 1 Q9UNL2-2;C9JA28;Q9UNL2;C9J365 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 111802500.0 3657500.0 2935000.0 105210000.0 True False 5009776.590221033 2805321.995252904 80361564.86796588 1.0 0.5599694806209177 16.04094781887675 22.2563148375417 -6.900360675525508 0.9590164529505671 0.36271197995237575 17.677710477096255 0.9867439962007688 0.8285473871046716 0.11113923032232935 0.1759399428397333 0.6475498649710294 1.6878243617190425 1.2578803257780524e-07 6.900360675525508 17.31499849714388 up EDAVSK(ub)EVTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDAVSKEVTR 10 1 Q9UNL2-2;C9JA28;Q9UNL2;C9J365 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 207557400.0 2617400.0 57630000.0 147310000.0 True False 3388275.896667384 54422839.83915852 120501091.52824149 1.0 16.062104001827993 35.564132084628376 21.692119922904567 -7.253616152287659 0.3870194818159009 2.0646669032767142e-14 46.725446689743286 0.9991209697011274 0.41951069194257107 0.13638908616883202 0.03894044822722784 0.665336383314763 3.068031028176359 5.576784308044112e-08 7.253616152287659 46.725446689743265 EDCASELK(ub)VHLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDCASELKVHLAK 13 1 B1AHQ6;Q9NSP4;B1AHQ7;B1AHQ8;Q9NSP4-4;Q9NSP4-2 B1AHQ6 CENPM Centromere protein M 1 5876300.0 1731700.0 1603300.0 2541300.0 True False 2371956.287432877 1532460.9045959061 1941097.279716392 1.0 0.6460746822001764 0.81835288871078 21.177645992157117 -10.130097661861964 4.887992067549926 1.0000149869169361 0.7322137854542522 0.763115854494586 0.07033228329636912 1.1487470623887516e-05 2.0443744957573044e-06 0.0681027495499924 0.022699646825027956 7.411435580897023e-11 10.130097661861964 -0.26780120146268394 EDEFSPLK(ub)NADSQNGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDEFSPLKNADSQNGK 16 1 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 1 4862800.0 1783300.0 1279300.0 1800200.0 True False 1726690.1176290687 1790131.1614613666 1328673.6151576194 1.0 1.0367414182687333 0.7694916427633415 20.719577760544237 -6.872164300905323 1.1226572390979648 1.0210755467246213 0.7531877789165596 0.9667922619176923 0.021553728792386633 0.1347927937057404 0.31621129180277735 0.01488006296550107 0.03536571616264887 1.3422570666525573e-07 6.872164300905323 -0.26788776780806167 EDEK(ub)DDKPIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDEKDDKPIR 10 2 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 56815000.0 20725000.0 24995000.0 11095000.0 True False 27170675.701185472 21265843.429746885 9946995.830755088 1.0 0.7826762817245301 0.3660930607743809 24.695547108263433 -6.960866534518826 0.4230447216529819 1.0178212301321783 0.1151548062402301 0.9998009978815935 0.0037103495946864654 0.07939302609467591 0.01999828205291449 0.005400140074587065 0.03464888581976608 1.0942926078226172e-07 6.960866534518826 -0.9026664238919482 down EDEK(ub)DDKPIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDEKDDKPIR 10 2 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 41222600.0 17948000.0 18427000.0 4847600.0 True False 17378250.564238496 25784997.19553551 3577868.135117247 1.0 1.48375103122271 0.20588195122930814 24.050779520280336 -6.8041485665045975 1.439061442520791 1.2655194630166813 0.1864114523462368 0.8439726572943556 0.20808438626476908 0.21489239377635494 0.8781176601547067 0.11373550540446602 0.2638497424077588 1.569825695477598e-07 6.8041485665045975 -1.0791080106704445 down EDEK(ub)DDKPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDEKDDKPIR 10 2 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 49584200.0 20725000.0 22090000.0 6769200.0 True False 28387592.57206582 21113990.758138586 5170454.3760501295 1.0 0.743775320310724 0.18213782528138722 24.758757169786325 -7.151643721132715 0.5274332600173738 1.0076879883897016 4.933434317501136e-13 0.9991217426220186 0.010122351034894547 0.08167206229541686 0.03734425475681686 0.011011737611185703 0.04620830035191569 7.052714098627704e-08 7.151643721132715 -1.0076879883892083 down EDEK(ub)DDKPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDEKDDKPIR 10 2 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 35629500.0 17948000.0 13515000.0 4166500.0 True False 14924557.231214752 13442192.01248254 5037695.8862806205 1.0 0.9006761007534723 0.33754407639941675 23.831184795714613 -6.937046128808143 0.6865027941060856 1.0067592920608581 0.1980360098670651 0.997750693106164 0.013834691173678805 0.08914071462725544 0.06094449023551045 0.013182671883721079 0.04913164923214943 1.1559894516665594e-07 6.937046128808143 -0.8087232821937931 down EDENSWFNLFVIHQNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDENSWFNLFVIHQNR 16 0 F8W7U8;P49959-2;P49959;P49959-3;F5GXT0 F8W7U8 MRE11A Double-strand break repair protein MRE11A 0 12743000.0 3635400.0 5922400.0 3185200.0 False True 4706096.964447394 5592813.233791992 2605526.282911915 1.0 1.1884186144151663 0.553649085982627 22.16609961548907 -6.827203690895803 1.3405972101524009 1.1008865460496018 0.5375514995245192 0.9001143966142117 0.08412514482535037 0.1842919523458908 0.648774350706344 0.04928691738817338 0.11343061456641494 1.4886627078872506e-07 6.827203690895803 -0.5633350465250826 EDFEEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDFEEAR 7 0 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 0 6067010.0 1667100.0 548310.0 3851600.0 False True 1614178.8230244035 767253.042398876 2842750.4144767714 1.0 0.47532096906172616 1.7611124454912974 20.622368982388274 -6.795930571388571 1.4725918828421836 0.7089972866866012 1.7771029269115384 0.819947428549765 0.22398983943379272 0.2266284402838352 0.9706288404871269 0.11968862584387034 0.2790549093990186 1.599813762856881e-07 6.795930571388571 1.0681056402249371 EDGAISTIVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDGAISTIVLR 11 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 31010800.0 6788800.0 10873000.0 13349000.0 False True 8900182.542832728 9250790.782622049 11967773.532649823 1.0 1.0393933762708791 1.3446660756736286 23.085403495396335 -6.9306922413522205 0.7410790351930885 0.9954751687912144 1.4084582056218418 0.9966727680360785 0.008885006323930954 0.09227957070314255 0.0759282903515901 0.008128318265215852 0.027517416354658944 1.1730263250192998e-07 6.9306922413522205 0.4129830368306273 EDGAISTIVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDGAISTIVLR 11 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 18618600.0 4732600.0 2377000.0 11509000.0 False True 4582366.203494273 3326148.495891242 8494447.637400858 1.0 0.7258582898404965 1.853725184801563 22.12766132671273 -6.842466606810883 1.270770165235316 0.8541677469636205 1.8926966455267968 0.9286230034028153 0.12831586354927974 0.1659446624483341 0.5194591053409532 0.07913971099204219 0.18247364734131047 1.437253560481941e-07 6.842466606810883 1.0385288985631762 EDGAISTIVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDGAISTIVLR 11 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 28540500.0 6788800.0 8580700.0 13171000.0 False True 9298802.820421752 8201576.301419633 10060281.065259743 1.0 0.8820034642962401 1.0818899227721719 23.148613556919226 -6.746722903208793 1.661755139816301 0.9303464350442341 1.0821955838364545 0.6348695763722978 0.049577062116744404 0.30578140028446965 1.6602505087016883 0.023577253122189615 0.05744241522979674 1.7917486948474027e-07 6.746722903208793 0.15184914879222045 EDGAISTIVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDGAISTIVLR 11 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 10423100.0 4732600.0 2472100.0 3218400.0 False True 3935366.589728494 2458782.3066265667 3891352.559799723 1.0 0.6247911727065308 0.9888157738484515 21.908066602147006 -10.746997157585819 9.81385427043746 1.000635427912735 0.8068034736123336 0.2730217806420916 0.14861242110297873 0.002072525330180153 5.3429973689132787e-05 0.14433693411705023 0.04796445266428337 1.790617573410835e-11 10.746997157585819 -0.19383195430040134 EDGLAQQQTQLNLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDGLAQQQTQLNLR 14 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 34524200.0 4251200.0 16221000.0 14052000.0 False True 5573364.368679357 13800890.028962765 12598033.836301994 1.0 2.476222460264691 2.260400182535917 22.410117044596102 -10.002544145449521 7.194607189780631 0.9999999088506931 2.3683113214003044 0.9816829630351487 0.08810907592679137 1.2887062639954137e-07 1.7845994214703176e-08 0.08531125228453117 0.02843708197618199 9.94159013891119e-11 10.002544145449521 1.3683114125496112 EDGLAQQQTQLNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDGLAQQQTQLNLR 14 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 8825100.0 2530200.0 970700.0 5324200.0 False True 2449880.185961457 1358305.5721336282 3929632.2974237283 1.0 0.5544375516472698 1.604009991974992 21.22427976371692 -6.7913568778236 1.4908101706604067 0.7514122224463843 1.615608028888229 0.8057117172189505 0.18958477874907306 0.23333946612378323 1.0244626708502433 0.10008685345140032 0.23410817682326154 1.6167509401962554e-07 6.7913568778236 0.8641958064418448 EDGLAQQQTQLNLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDGLAQQQTQLNLR 14 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 22801500.0 4251200.0 8611900.0 9938400.0 False True 5822983.524360251 8231397.782255032 7591154.607772946 1.0 1.413604855280676 1.3036538015289951 22.473327106118994 -10.179467622510929 5.110703304553761 0.999977031100661 1.3586293284051387 0.934145850450937 0.044887329729888126 1.1748528955019424e-05 1.8862312412905179e-06 0.04346475058530654 0.014487323374812035 6.615038520304834e-11 10.179467622510929 0.3586522973044777 EDGLAQQQTQLNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDGLAQQQTQLNLR 14 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 4145000.0 2530200.0 0.0 1614800.0 False True 2103973.406865364 0.0 1952447.214008384 1.0 0.0 0.9279809372292716 21.004685039151195 -10.024413594611328 12.962503773448095 0.9999900992989158 0.4639904686145984 0.30788273414323697 0.3788466312500273 0.0 0.0 0.36681667338004914 0.12227222446001634 9.453364538647067e-11 10.024413594611328 -0.5359996306843173 EDGMVPFVFVGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDGMVPFVFVGTK 13 0 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 0 7513100.0 2211900.0 2404000.0 2897200.0 False True 2899822.3200700697 2045332.5707186067 2597425.5359047884 1.0 0.7053303081925324 0.8957188576443628 21.467533074458565 -10.701612552194238 5.9239959350759035 1.003405989884837 0.8005245829184483 0.5940974162144859 0.07772579983760439 0.003548509449746023 0.00017873576972772905 0.07637860487873566 0.025085894028474415 1.987867565878535e-11 10.701612552194238 -0.2028814069663888 EDGMVPFVFVGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDGMVPFVFVGTK 13 0 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 0 8831600.0 2211900.0 2181700.0 4438000.0 False True 3029699.2043499365 2085305.2800828856 3389835.8034790657 1.0 0.6882878924379282 1.1188687638073302 21.530743135981457 -6.712478787636885 1.7860874250720193 0.8088589402937845 1.1179462128874784 0.47701860817802355 0.1313035064688127 0.37010317162712203 2.3029479537733977 0.058465431399414236 0.14810057529843565 1.9387473284009894e-07 6.712478787636885 0.30908727259369395 EDGNEEDK(ub)ENQGDETQGQQPPQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDGNEEDKENQGDETQGQQPPQR 23 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 248850070.0 85568000.0 119110070.0 44172000.0 True False 112180476.64169078 101339311.84341648 39601505.16774349 1.0 0.903359611914456 0.35301601805662125 26.741246377086313 -6.936950548536918 0.6873532755651093 1.006623152547026 0.21703918663551264 0.9977364855322413 0.013557240770037136 0.0891859658726234 0.06115524937500546 0.012909816692979229 0.04803789272511739 1.1562438917969575e-07 6.936950548536918 -0.7895839659115134 down EDGNEEDK(ub)ENQGDETQGQQPPQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDGNEEDKENQGDETQGQQPPQR 23 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 207697570.0 93008950.0 74107620.0 40581000.0 True False 90056431.79277529 103699179.13213286 29951618.696095623 1.0 1.1514910936150597 0.33258722447515926 26.42432598070042 -6.858932446072565 1.1911448323358629 1.0819686460966238 0.2937377579495702 0.95232816299805 0.07767302128994735 0.14790396851377477 0.399367590407357 0.05088194227831711 0.11863247451585691 1.3837816076155774e-07 6.858932446072565 -0.7882308881470537 down EDGNEEDK(ub)ENQGDETQGQQPPQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDGNEEDKENQGDETQGQQPPQR 23 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 237340700.0 85568000.0 111165700.0 40607000.0 True False 117204801.98825239 106254031.79818955 31016462.927416496 1.0 0.9065672224661883 0.2646347453453769 26.804456438609204 -6.933040222214546 0.7213990324443299 1.0087462502058495 0.12202970118902924 0.9971027744475984 0.017593818718235815 0.09108966107707712 0.07016971987744053 0.016329170273336045 0.05714387775727816 1.1667015579087398e-07 6.933040222214546 -0.8867165490168203 down EDGNEEDK(ub)ENQGDETQGQQPPQRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDGNEEDKENQGDETQGQQPPQRR 24 2 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 11319000.0 5651900.0 3324700.0 2342400.0 True False 7409695.633077459 2828667.7195790955 2100030.9178874013 1.0 0.38175221488878736 0.28341662355369895 22.820982851711122 -13.999999999999998 0.25876748502803926 5.496935181549304 0.24704904539026812 0.9995598290188854 0.006654380028322529 14.362940735324225 0.16097120362989922 33.74982663368315 0.04327180670362804 1.0000000000000041e-14 13.999999999999998 -5.249886136159036 EDGNEEDK(ub)ENQGDETQGQQPPQRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDGNEEDKENQGDETQGQQPPQRR 24 2 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 16410700.0 5651900.0 9257100.0 1501700.0 True False 7741560.166854475 8848090.712863946 1147029.3884823138 1.0 1.1429337914012587 0.14816514549526147 22.884192913234013 -6.870446264107995 1.1316624750206414 1.0810695032018478 0.08939277763001942 0.9651301002713155 0.08200325370645775 0.13643133243556832 0.326273059151265 0.05621897885970313 0.13321182399003104 1.347577452760412e-07 6.870446264107995 -0.9916767255718284 down EDGNEEDKENQGDETQGQQPPQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDGNEEDKENQGDETQGQQPPQR 23 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 0 73885970.0 566970.0 42933000.0 30386000.0 False True 743303.160545291 36527563.75152324 27241948.203093667 1.0 49.1422150347463 36.64984847247096 19.50359121684478 -9.688671921614981 8.36264780749362 0.9998921994613419 42.8960317536094 0.9374870223052458 5.099987293276732 0.0 0.0 4.938041463010901 1.646013821003633 2.047991163191038e-10 9.688671921614981 41.89613955414806 EDGNEEDKENQGDETQGQQPPQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDGNEEDKENQGDETQGQQPPQR 23 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 0 62820500.0 18967000.0 5121500.0 38732000.0 False True 18364902.967010904 7166541.658269681 28586927.264906574 1.0 0.3902303034839349 1.5566064964382123 24.130447937662975 -6.764646181903163 1.595009421309295 0.6478666806404774 1.561872306401029 0.7096476520299739 0.25667053527612976 0.275173066130328 1.3806933350627246 0.12690946458126973 0.30359752129120365 1.7193085309906392e-07 6.764646181903163 0.9140056257605516 EDGNEEDKENQGDETQGQQPPQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDGNEEDKENQGDETQGQQPPQR 23 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 0 73342970.0 566970.0 34864000.0 37912000.0 False True 776594.1307881394 33323593.200169407 28957966.422149267 1.0 42.909921513764736 37.28841781582974 19.56680127836767 -9.858091555963684 11.20820593950808 1.000000001564852 40.09917023561653 0.9847331390837343 2.2949692745182944 0.0 0.0 2.222094445066832 0.7406981483556104 1.3864635102047908e-10 9.858091555963684 39.099170234051684 EDGQEYAQVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDGQEYAQVIK 11 0 O14602;A6NJH9;P47813 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 0 17261200.0 6357100.0 1662800.0 9241300.0 False True 6155297.340200615 2326764.7113874475 6820726.296942624 1.0 0.3780101240911967 1.108106711985472 22.553397119108105 -6.681097306634237 1.8985178143202714 0.606838073545178 1.1053173837319306 0.3289619643709061 0.2635523761411347 0.43606451852679956 3.0398876145214486 0.11136596830676662 0.29325111993081665 2.084023891047371e-07 6.681097306634237 0.4984793101867525 EDGQEYAQVIK(ub)MLGNGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDGQEYAQVIKMLGNGR 17 1 O14602;A6NJH9;P47813 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 1 7610900.0 2192900.0 3737400.0 1680600.0 True False 2874913.136073808 3179794.488271093 1506707.6334535382 1.0 1.106048891833182 0.5240880548868369 21.455086935799017 -6.859720095676488 1.1872501086510276 1.057491564417636 0.4960715265104901 0.9532855050990133 0.05469818906091576 0.14709413421245085 0.3941570900975952 0.035938664728160964 0.08385968893248659 1.3812742138811317e-07 6.859720095676488 -0.5614200379071459 EDGQEYAQVIK(ub)MLGNGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDGQEYAQVIKMLGNGR 17 1 O14602;A6NJH9;P47813 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 1 15426800.0 7680500.0 5761900.0 1984400.0 True False 7436686.731593152 8062656.717911555 1464626.109276067 1.0 1.084173235865793 0.19694605435696524 22.826228569613566 -6.8836449648624605 1.0592240735107983 1.0551837120172722 0.1294931726991518 0.9765101091368176 0.06128761245887009 0.12445201285612312 0.25317085476882917 0.044413873448509056 0.10847477933934112 1.3072391176026524e-07 6.8836449648624605 -0.9256905393181204 down EDGSSK(ub)SPDCPVCSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDGSSKSPDCPVCSR 15 1 E7ESC7;Q7L5Y9;Q7L5Y9-3;Q7L5Y9-2;B4DQT1;B4DVN3;D6RIB6;Q7L5Y9-4 E7ESC7 MAEA Macrophage erythroblast attacher 1 3859530.0 567540.0 798290.0 2493700.0 True False 777374.8751918094 763018.9082079876 1904739.4193636202 1.0 0.9815327618090569 2.4502199391170767 19.568250954866773 -6.9040528404828 0.9352837309238947 0.9455401368585752 2.6177306858767198 0.9884771830702781 0.07385661970507008 0.10848345133931629 0.16107011406056632 0.05874297060621328 0.1561950335133443 1.2472317546874567e-07 6.9040528404828 1.6721905490181446 up EDGVTPYMIFFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDGVTPYMIFFK 12 0 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;H0YCX0 P13693 TPT1 Translationally-controlled tumor protein 0 4119500.0 1021100.0 1997100.0 1101300.0 False True 1338671.9883464677 1699140.4646348287 987348.040415554 1.0 1.2692731897181273 0.737557855106186 20.352371073110177 -6.769044700761581 1.5783147515913036 1.1546361036187625 0.7346879909553041 0.7268353840567856 0.11345606783994981 0.2679683434205718 1.3172829834047992 0.05666845104988043 0.1350017883778751 1.7019833188191978e-07 6.769044700761581 -0.41994811266345833 EDGVTPYMIFFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDGVTPYMIFFK 12 0 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;H0YCX0 P13693 TPT1 Translationally-controlled tumor protein 0 6573200.0 1021100.0 2086500.0 3465600.0 False True 1398628.264189938 1994311.530867187 2647096.6562724314 1.0 1.4259053545026552 1.8926377537533785 20.41558113463307 -6.96995001367727 0.25937675314625064 0.8679633998545511 2.4644157160652016 0.9999819902533462 0.0015470408058024653 0.07631891868390743 0.009088138383664282 0.009782511372110008 0.04407821100861827 1.071642641808866e-07 6.96995001367727 1.5964523162106505 EDGVTPYMIFFK(ub)DGLEMEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDGVTPYMIFFKDGLEMEK 19 1 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;H0YCX0 P13693 TPT1 Translationally-controlled tumor protein 1 32684200.0 4896200.0 11595000.0 16193000.0 True False 7427893.3601668645 9525781.657851517 12992446.452355979 1.0 1.2824338201911833 1.7491428353064171 22.82452167244581 -6.963599063844625 0.3813370151298382 0.9684196266574397 2.079696004791098 0.9998812830329636 0.0033657419270641115 0.07843968276479778 0.016556713906545003 0.006065666460758513 0.039411387542171196 1.087429063581243e-07 6.963599063844625 1.1112763781336583 EDGVTPYMIFFK(ub)DGLEMEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDGVTPYMIFFKDGLEMEK 19 1 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;H0YCX0 P13693 TPT1 Translationally-controlled tumor protein 1 26704300.0 4896200.0 7798100.0 14010000.0 True False 6338227.418530928 7364128.879919176 11460323.75473939 1.0 1.1618593644003439 1.8081275722662 22.59564799453826 -6.944917008867306 0.6121208708171366 0.9928720596844466 2.010892700042076 0.9987394960730883 0.01239482784168343 0.08559349986126222 0.04492210729390338 0.012573904603855582 0.05453582452169819 1.1352277303185912e-07 6.944917008867306 1.0180206403576295 EDHTLGNIIK(ub)SQLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDHTLGNIIKSQLLK 15 1 P52435;A0A0B4J2F8;F6S314;E2QRJ6;A6NFM0;Q9H1A7;Q9GZM3 P52435 POLR2J;POLR2J3;POLR2J2 DNA-directed RNA polymerase II subunit RPB11-a;DNA-directed RNA polymerase II subunit RPB11-b2;DNA-directed RNA polymerase II subunit RPB11-b1 1 14379500.0 1582700.0 2169800.0 10627000.0 True False 1532458.0548261805 3036212.455357522 7843469.896833686 1.0 1.9812695334763373 5.118228112105381 20.547416155525763 -6.950013815851649 0.558691469286542 0.9586884124726912 6.2903932682591766 0.9992023705669869 0.049603703506839486 0.08348018735669507 0.0359393425504382 0.053256761950818333 0.26069276435894606 1.1219827610233477e-07 6.950013815851649 5.3317048557864855 EDHTLGNIIK(ub)SQLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDHTLGNIIKSQLLK 15 1 P52435;A0A0B4J2F8;F6S314;E2QRJ6;A6NFM0;Q9H1A7;Q9GZM3 P52435 POLR2J;POLR2J3;POLR2J2 DNA-directed RNA polymerase II subunit RPB11-a;DNA-directed RNA polymerase II subunit RPB11-b2;DNA-directed RNA polymerase II subunit RPB11-b1 1 8981900.0 1582700.0 2459000.0 4940200.0 True False 1316085.1754983063 2445752.8789267144 5973172.979095999 1.0 1.8583545536866066 4.538591491112564 20.32782143096004 -6.950547300577114 0.5528019490407835 0.9635339888135078 5.559932444660021 0.9992435400167482 0.041450920625373144 0.08326670235712617 0.03505850576400192 0.04482959897539638 0.22246845871620818 1.1206053703207334e-07 6.950547300577114 4.596398455846513 EDIPETK(ub)MK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDIPETKMK 9 1 Q13287 Q13287 NMI N-myc-interactor 1 23373800.0 3733900.0 6012900.0 13627000.0 True False 5664599.284654834 4939851.01599787 10933617.477073714 1.0 0.8720565688343962 1.9301660943065175 22.43354247232696 -6.876674589095393 1.0981221106407413 0.9236995554045537 2.0005471491584 0.9709051758092063 0.08043203670698672 0.13061916564135076 0.29040204756484084 0.056578821246234326 0.13574425414998276 1.3283894289216074e-07 6.876674589095393 1.0768475937538462 EDIPETK(ub)MK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDIPETKMK 9 1 Q13287 Q13287 NMI N-myc-interactor 1 23118300.0 3733900.0 7754400.0 11630000.0 True False 4833607.156172661 7322860.823334568 9513459.33387717 1.0 1.5149888244399539 1.9681904272522845 22.20466879441941 -6.972628567252029 0.184918173771695 0.6716811319522396 2.823814338329932 0.9999962886733513 0.0007619594677824317 0.07545865450132563 0.00586443800658307 0.01671556248891848 0.0501212980497006 1.0650535217035727e-07 6.972628567252029 2.152133206377693 EDIQQFFEEFQSK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDIQQFFEEFQSKK 14 1 Q8N806;H0YJY4;H0YJM2 Q8N806 UBR7 Putative E3 ubiquitin-protein ligase UBR7 1 12901500.0 3919500.0 2912000.0 6070000.0 True False 3795077.6179258334 4074776.7858793833 4480084.903903308 1.0 1.0737005131680066 1.1804988869639668 21.85569796164517 -6.965825891896945 0.3436035251516862 0.9888892068825496 1.2688787591281916 0.999929144964396 0.0006237146073232533 0.07768203556834931 0.013879276980892735 0.0014915834582794425 0.009219900942415513 1.0818675837031888e-07 6.965825891896945 0.27998955224564204 EDIQQFFEEFQSK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDIQQFFEEFQSKK 14 1 Q8N806;H0YJY4;H0YJM2 Q8N806 UBR7 Putative E3 ubiquitin-protein ligase UBR7 1 12237700.0 3919500.0 2886700.0 5431500.0 True False 3259237.9132909672 2871148.774134916 6567201.537581466 1.0 0.880926416088421 2.014950031969385 21.636103237079446 -6.88096279600299 1.0744555495294625 0.9252253884768741 2.0968031473598474 0.9744520601344284 0.08133241907767938 0.12677879619070673 0.26718357084454747 0.058260931216119936 0.14123599379964213 1.3153375062387572e-07 6.88096279600299 1.1715777588829734 up EDIQQFFEEFQSK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDIQQFFEEFQSKK 14 1 Q8N806;H0YJY4;H0YJM2 Q8N806 UBR7 Putative E3 ubiquitin-protein ligase UBR7 1 16935300.0 2489000.0 6377900.0 8068400.0 True False 3222059.565524994 6022964.25837532 6600033.98877512 1.0 1.8692901654640743 2.048389812340334 21.61955173440937 -10.868056739943528 0.30550668527684466 3.158927746542661e-09 2.0994615263218517 0.999213835253177 0.012838246194923351 2.643329170936522 0.15405013668490397 1.9641571468111394 0.0629173760202136 1.3550123703872409e-11 10.868056739943528 2.099461523162924 EDITQEFPGK(ub)GK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDITQEFPGKGK 12 1 D3DQV9;P78344;H0Y3P2;P78344-2;H0YE22 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 1 6215900.0 2919900.0 1377300.0 1918700.0 True False 3828017.176351819 1171812.2086733517 1720171.329470015 1.0 0.30611466842740587 0.449363534755446 21.868165872549888 -9.987032893247946 7.156709664165207 1.0000000350316907 0.3777391015993214 0.961772915689658 0.058481104789310324 3.269609270159419e-08 4.5980382466062895e-09 0.056624089604241146 0.018874695409733914 1.0303080824649101e-10 9.987032893247946 -0.6222609334323692 EDITQEFPGK(ub)GK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDITQEFPGKGK 12 1 D3DQV9;P78344;H0Y3P2;P78344-2;H0YE22 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 1 3678400.0 1056100.0 1042800.0 1579500.0 True False 1022574.683579914 1459195.4781301608 1165781.5660156985 1.0 1.4269818151782212 1.140045401803254 19.96377478334273 -10.536127693764474 5.576425092873848 0.9992657825283923 1.2835136084907353 0.5655409585350843 0.1171413002321635 0.0010719560800398504 8.916996729350708e-05 0.11370517058184484 0.037807192079354235 2.9098614180631394e-11 10.536127693764474 0.284247825962343 EDITQSAQHALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDITQSAQHALR 12 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 19561870.0 5678800.0 840870.0 13042200.0 False True 5498529.602417956 1176633.77607912 9626056.562386774 1.0 0.21399062315890782 1.7506601325113815 22.390614439067924 -6.767667530818056 1.5834383722023466 0.5478247552128809 1.7585415692613264 0.7215453943677194 0.3310703981977378 0.2702143959874235 1.3367213932410333 0.16484209579596656 0.39322925374705026 1.7073889609481676e-07 6.767667530818056 1.2107168140484457 EDIYSSAK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDIYSSAKK 9 1 D6RCD0;Q8NBQ5 D6RCD0 HSD17B11 Estradiol 17-beta-dehydrogenase 11 1 11729000.0 3788400.0 5178300.0 2762300.0 True False 4966629.086917785 4405717.824855305 2476483.693852619 1.0 0.88706399204645 0.4986246507466671 22.243835578139738 -6.948344201073835 0.5767363890867659 1.00470219170651 0.36188106436475737 0.999064847891396 0.006566782010190419 0.08415754619703074 0.038767308082469004 0.00690481095913803 0.03242016939545997 1.1263044472072251e-07 6.948344201073835 -0.6428211273417526 down EDIYSSAK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDIYSSAKK 9 1 D6RCD0;Q8NBQ5 D6RCD0 HSD17B11 Estradiol 17-beta-dehydrogenase 11 1 7716800.0 2989400.0 2741600.0 1985800.0 True False 2894503.133314828 3836335.177255124 1465659.407276968 1.0 1.3253864309560086 0.5063595856600346 21.464884287616762 -6.7989138117372745 1.4604260912235854 1.1797775231973129 0.4953648056184624 0.8289475250677656 0.139258142707093 0.2223108075926479 0.9362198068807156 0.07502042846578773 0.17458016006622779 1.5888620362121098e-07 6.7989138117372745 -0.6844127175788505 EDIYSSAK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDIYSSAKK 9 1 D6RCD0;Q8NBQ5 D6RCD0 HSD17B11 Estradiol 17-beta-dehydrogenase 11 1 9620800.0 2289700.0 2461600.0 4869500.0 True False 3473642.2994922656 2022308.2474314165 3907041.190622332 1.0 0.5821866712433266 1.1247678528078195 21.728017768588902 -6.701000861465233 1.8271849187764213 0.7408188153535242 1.123193551283138 0.42246604289914336 0.17633054285922373 0.393398963533481 2.554109316116233 0.07696704738906925 0.1977032210584468 1.9906693902974325e-07 6.701000861465233 0.3823747359296137 EDIYSSAK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDIYSSAKK 9 1 D6RCD0;Q8NBQ5 D6RCD0 HSD17B11 Estradiol 17-beta-dehydrogenase 11 1 8755400.0 3788400.0 2610700.0 2356300.0 True False 5189073.857660516 2495350.641569597 1799790.4695217954 1.0 0.48088555106722286 0.3468423304217966 22.30704563966263 -13.999999999999993 0.1900964641786758 3.78369330315912 0.2507716895646208 0.9994893546243462 0.006365116134801349 12.352305467487732 0.1382650036657591 12.736951704922573 0.09211273582811502 1.0000000000000164e-14 13.999999999999993 -3.532921613594499 EDIYSSAK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDIYSSAKK 9 1 D6RCD0;Q8NBQ5 D6RCD0 HSD17B11 Estradiol 17-beta-dehydrogenase 11 1 8490300.0 2989400.0 3432600.0 2068300.0 True False 2485818.552874602 3414107.902482245 2500771.967261296 1.0 1.3734340740735758 1.006015489090868 21.24528956305104 -9.744526900723306 11.01292045710032 0.9999994089647342 1.1897247811861835 0.26227599076592745 0.1499980092042302 0.0 0.0 0.14523494790288718 0.04841164930096238 1.8008315853097614e-10 9.744526900723306 0.18972537222144936 EDIYSSAK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDIYSSAKK 9 1 D6RCD0;Q8NBQ5 D6RCD0 HSD17B11 Estradiol 17-beta-dehydrogenase 11 1 6309100.0 2289700.0 1914800.0 2104600.0 True False 2964061.786734658 1808239.6967555222 1721584.3950195976 1.0 0.610054657041262 0.5808193347130498 21.49914409068135 -13.999999999999998 0.3675238830287729 6.347836276028746 0.577669945276389 0.9997866317927872 0.002791210838044268 22.533594862593233 0.19655986443749748 94.837957492682 0.008234650501252877 1.0000000000000041e-14 13.999999999999998 -5.770166330752357 EDK(ub)IHNAENIQPGEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDKIHNAENIQPGEQK 16 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 8984600.0 1584200.0 2754000.0 4646400.0 True False 2050778.1292505793 2600737.479039437 3800802.876090015 1.0 1.2681710624590241 1.853346698932737 20.967739986473767 -6.958305769216317 0.45869286398229336 0.9827186982567565 2.1623367635052904 0.9997020928144355 0.00614972999802161 0.08031205510386769 0.023410679943913795 0.007929841822847455 0.048348413604332834 1.100764033124811e-07 6.958305769216317 1.1796180652485337 EDK(ub)SPSEESAPTTSPESVSGSVPSSGSSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDKSPSEESAPTTSPESVSGSVPSSGSSGR 30 1 P54725-3;P54725;P54725-2;A0A494C0B4 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 509180000.0 179900000.0 177080000.0 152200000.0 True False 235850642.15407807 150660354.25243378 136451804.00549114 1.0 0.638795607577822 0.5785517595341081 27.813298288019165 -13.999999999999998 0.2520142226925736 3.537731200005934 0.5547885704571083 0.999546510320321 0.0039631628816019174 14.0788053656848 0.1588516926055863 18.108490830963227 0.02749440778986389 1.0000000000000041e-14 13.999999999999998 -2.982942629548826 EDK(ub)SPSEESAPTTSPESVSGSVPSSGSSGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDKSPSEESAPTTSPESVSGSVPSSGSSGR 30 1 P54725-3;P54725;P54725-2;A0A494C0B4 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 576010000.0 178740000.0 195240000.0 202030000.0 True False 173065996.5373293 273200350.1631495 149112282.2299153 1.0 1.5785905702407683 0.8615920239291643 27.36674705546204 -6.691954248098195 1.8592254295984108 1.362075922974018 0.863996204362921 0.3796201540883226 0.2446077048783899 0.4125261448500925 2.766172529922023 0.10518428919280078 0.2732592533473417 2.0325711262434075e-07 6.691954248098195 -0.498079718611097 EDK(ub)SPSEESAPTTSPESVSGSVPSSGSSGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDKSPSEESAPTTSPESVSGSVPSSGSSGR 30 1 P54725-3;P54725;P54725-2;A0A494C0B4 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 1057540000.0 452960000.0 438570000.0 166010000.0 True False 687173435.811687 360303756.93694985 133198050.73523213 1.0 0.5243272486389994 0.19383469120557467 29.356099026128994 -8.193937647347912 0.29756294228703645 1.14513061461263 3.404473695990077e-16 0.9990353888412322 0.010276835910775656 0.09144737509039741 0.06696116681120963 0.07930451525297123 0.09494159077628643 6.398266902699269e-09 8.193937647347912 -1.1451306146126297 down EDK(ub)SPSEESAPTTSPESVSGSVPSSGSSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDKSPSEESAPTTSPESVSGSVPSSGSSGR 30 1 P54725-3;P54725;P54725-2;A0A494C0B4 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 594490000.0 179900000.0 232700000.0 181890000.0 True False 246413891.61469924 222418544.56400394 138931328.14213786 1.0 0.9026217763395612 0.5638128890857151 27.876508349542057 -6.948080048685445 0.5795379863998132 1.0040569654893088 0.4456329461697521 0.999041878248979 0.005786581968210118 0.08426597383078238 0.03922444465657391 0.006065860307420585 0.028299100640823145 1.1269897115154596e-07 6.948080048685445 -0.5584240193195567 EDK(ub)SPSEESAPTTSPESVSGSVPSSGSSGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDKSPSEESAPTTSPESVSGSVPSSGSSGR 30 1 P54725-3;P54725;P54725-2;A0A494C0B4 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 572122000.0 178740000.0 327420000.0 65962000.0 True False 148630229.52458894 325656123.4722185 79754349.22617114 1.0 2.191049051823895 0.5365957482624812 27.147152330896315 -6.713544647019541 1.7828226418986415 1.7295723504883174 0.5401026143494093 0.4818239349252881 0.501632675342434 0.36798445661923823 2.2821486445991006 0.2237433388290345 0.5659296594324572 1.9339950268221915e-07 6.713544647019541 -1.189469736138908 EDK(ub)SPSEESAPTTSPESVSGSVPSSGSSGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDKSPSEESAPTTSPESVSGSVPSSGSSGR 30 1 P54725-3;P54725;P54725-2;A0A494C0B4 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 1163140000.0 452960000.0 598650000.0 111530000.0 True False 586365649.1764569 565334601.2443566 91232684.39443858 1.0 0.964133219669948 0.15559009045392364 29.127225348221444 -6.916191707519104 0.8525038009171456 1.0204045753999877 0.035984075917130674 0.9930556249596918 0.03248982268889167 0.10046505027146002 0.1176126376999458 0.027442611039500516 0.07943412655146352 1.2128533510687948e-07 6.916191707519104 -0.984420499482857 down EDKYEEEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDKYEEEIK 9 1 J3KN67;A0A2R2Y2Q3;P06753;P06753-7;Q5TCU3;CON__Q3SX28;A7XZE4;P07951-3;P07951;P07951-2;A0A494C034;A0A2R8Y6A3;U3KQK2;P06753-2;P06753-5;P06753-3;P06753-6;P06753-4;P67936;A0A2R8Y5V9;A0A2R8YE05;K7ENT6;P67936-2;A0A2R8YH90;A0A2R8YHD2;A0A5F9UN72;K7EPB9 J3KN67;P06753-2;P67936 TPM3;TPM2;TPM2b;TPM4 Tropomyosin alpha-3 chain;Tropomyosin beta chain;Tropomyosin alpha-4 chain 0 17851600.0 4325800.0 1521800.0 12004000.0 False True 4188479.8468232052 2129462.676082163 8859792.28771916 1.0 0.5084094358714119 2.115276332161168 21.997995301224254 -6.824605566462922 1.3519233712801648 0.7362018872678068 2.1539160605475773 0.8946306172440668 0.21822324759435663 0.18756491656732244 0.6723255309171616 0.12680544158386206 0.2919562998347651 1.497595179705731e-07 6.824605566462922 1.4177141732797707 up EDLGGCWQK(ub)LAELEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDLGGCWQKLAELEGR 16 1 Q15834 Q15834 CCDC85B Coiled-coil domain-containing protein 85B 1 7005000.0 3162100.0 1300200.0 2542700.0 True False 2629426.254781823 1293195.5645305072 3074366.813883528 1.0 0.49181663192824937 1.1692158349345394 21.326316604704303 -6.705947350479675 1.8094108289318553 0.6862876563716236 1.1674540462378906 0.4458293218890321 0.21428822953291193 0.38334252664278357 2.4438353998774054 0.09433156036312283 0.24085319714301948 1.9681248710243479e-07 6.705947350479675 0.48116638986626703 EDLGGCWQK(ub)LAELEGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDLGGCWQKLAELEGR 16 1 Q15834 Q15834 CCDC85B Coiled-coil domain-containing protein 85B 1 23054100.0 6596600.0 10988000.0 5469500.0 True False 8539428.738425944 10376508.14077173 4474107.121809223 1.0 1.2151290746275858 0.5239351786702685 23.02570813052754 -6.823095723126519 1.3585010439259615 1.1156028312836148 0.5078292002467296 0.8913414930484779 0.09519942849319918 0.18948864191325404 0.6863034609535592 0.055056943872258776 0.12680014302828818 1.5028106941102626e-07 6.823095723126519 -0.6077736310368852 EDLLSAK(ub)VCDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDLLSAKVCDLK 12 1 A0A0A0MTP7;Q99590;A0A087WUE7 A0A0A0MTP7 SCAF11 Protein SCAF11 1 51568900.0 2923500.0 7271100.0 41374300.0 True False 4435163.236478864 5973515.395636406 33196651.47000007 1.0 1.3468535603164993 7.484877038337678 22.08055577331493 -6.918533621560052 0.835526943457242 0.8572779909299302 8.442067223656524 0.993763851617727 0.23521902192116248 0.09904242033401987 0.11014072824260292 0.2011069333413683 0.5942224034109778 1.206330694678129e-07 6.918533621560052 7.584789232726594 up EDLLSAK(ub)VCDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDLLSAKVCDLK 12 1 A0A0A0MTP7;Q99590;A0A087WUE7 A0A0A0MTP7 SCAF11 Protein SCAF11 1 40335300.0 2923500.0 7819300.0 29592500.0 True False 3784528.3808004484 7384149.081282884 24206968.644691363 1.0 1.9511411563839551 6.396297294927791 21.85168209540738 -6.941322188944209 0.6471455912740118 0.9510204285674031 7.643127368449367 0.9983320108534494 0.09605516354818175 0.08716857216790827 0.05190130193080347 0.09446727962335558 0.38041224195197604 1.1446634378177065e-07 6.941322188944209 6.692106939881963 EDLMGLAIGTHGSNIQQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDLMGLAIGTHGSNIQQAR 19 0 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 0 30029700.0 6046700.0 10942000.0 13041000.0 False True 7927282.256326096 9309496.251581939 11691642.418105185 1.0 1.1743616476066328 1.4748613762017961 22.918394914780656 -6.962847904692006 0.3932485458450016 0.9821994244704096 1.677877175350785 0.9998616698425241 0.0023067284171855956 0.07869911813355791 0.017484323589490598 0.003873617051715005 0.025243337147047403 1.0893115169285027e-07 6.962847904692006 0.6956777508803754 EDLMGLAIGTHGSNIQQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDLMGLAIGTHGSNIQQAR 19 0 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 0 13262400.0 5864600.0 1806300.0 5591500.0 False True 5678431.483119742 2527565.009730062 4126918.408595613 1.0 0.4451167575489372 0.7267708381907385 22.437061047640757 -10.288178794176133 4.983352245840074 1.0001174353651145 0.5859437978696891 0.7423705500081642 0.11498479692485522 0.00015006852005466738 2.1435760683856447e-05 0.11136492186751655 0.037111183629654855 5.150165743733932e-11 10.288178794176133 -0.41417363749542546 EDLMGLAIGTHGSNIQQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDLMGLAIGTHGSNIQQAR 19 0 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 0 21320900.0 6046700.0 5197200.0 10077000.0 False True 8282328.395923307 4967570.519157882 7697020.142329546 1.0 0.5997794680060016 0.929330470175288 22.981604976303547 -9.981109983779087 6.801884532590796 1.0000000276386793 0.7645549690906439 0.4049636363434499 0.13453863325626722 5.639908042689603e-08 8.561401519079904e-09 0.13026648703470622 0.043422157168585385 1.0444556804470317e-10 9.981109983779087 -0.23544505854803544 EDLMGLAIGTHGSNIQQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDLMGLAIGTHGSNIQQAR 19 0 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 0 13505000.0 5864600.0 3761400.0 3879000.0 False True 4876674.745831406 3741136.5916205524 4690080.965530421 1.0 0.7671490896165437 0.9617374973673432 22.217466323075033 -10.065624187248373 6.118142143648779 1.0000002603016989 0.8644432935979164 0.3928588229246094 0.07944038480836173 2.820551623028678e-07 4.308806926777874e-08 0.07691796969923916 0.02563927394825593 8.597571827011653e-11 10.065624187248373 -0.13555696670378248 EDLNCQEEEDPMNK(ub)LK ddPTM_RPMI8226_Bortezomib_1h_R1 2 EDLNCQEEEDPMNKLK 16 1 O75821;K7EL20;K7ENA8 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 1 69673000.0 23139100.0 36158900.0 10375000.0 True False 30335584.179363176 30764133.066288304 9301494.5240274 1.0 1.0141269370120343 0.30661992427873075 24.854507758162068 -6.902345134020985 0.9463222848377356 1.0275528414253952 0.22871417325448778 0.9876973777033092 0.03662958150775421 0.10969963410672967 0.16784382442824822 0.02889758040330551 0.07611107385945413 1.2521456986886194e-07 6.902345134020985 -0.7988386681709074 down EDLNCQEEEDPMNK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDLNCQEEEDPMNKLK 16 1 O75821;K7EL20;K7ENA8 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 1 47879700.0 24405000.0 15604000.0 7870700.0 True False 23630276.633621585 21834758.573785003 5809127.55406125 1.0 0.9240162065101732 0.24583409005867998 24.494133182885037 -6.928118678157689 0.7620762809290438 1.0110649268986949 0.11305021828781091 0.996155404886316 0.02102147275768746 0.09362653704642428 0.0825525753755881 0.018941477057704582 0.06201072546312086 1.1799981375617329e-07 6.928118678157689 -0.898014708610884 down EDLNCQEEEDPMNK(ub)LK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDLNCQEEEDPMNKLK 16 1 O75821;K7EL20;K7ENA8 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 1 101568000.0 48830000.0 36355000.0 16383000.0 True False 74078679.951176 29867166.20708855 13144892.869076008 1.0 0.4031816742249388 0.17744502031812098 26.14255505486071 -10.793538225267234 0.20012088289524937 1.9085746165081203 4.761195171398379e-12 0.999378911769334 0.008648066513890013 2.7196075653488805 0.10788035944358368 1.3098096509100894 0.13810458052834632 1.608650783153328e-11 10.793538225267234 -1.908574616503359 EDLNCQEEEDPMNK(ub)LK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDLNCQEEEDPMNKLK 16 1 O75821;K7EL20;K7ENA8 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 1 57896000.0 19417000.0 28430000.0 10049000.0 True False 26595989.624694917 27173868.594562232 7675633.165651446 1.0 1.0217280491541003 0.28860114904408235 24.664705384195308 -6.9000687698278185 0.9608183781340439 1.0304232485026292 0.21153560173694802 0.9866009137594891 0.03942520514242646 0.11135517561164458 0.17712818341837258 0.03077055207390697 0.08008866781271502 1.258726078776634e-07 6.9000687698278185 -0.8188876467656812 down EDLNCQEEEDPMNK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 EDLNCQEEEDPMNKLK 16 1 O75821;K7EL20;K7ENA8 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 1 53149900.0 28197500.0 18018400.0 6934000.0 True False 23447470.61105293 17921331.302827645 8383867.340806393 1.0 0.7643183181720116 0.3575595628150318 24.48292896504566 -6.962821811150291 0.3936501645105268 1.0239877714609107 0.08318899946085453 0.9998609660251487 0.003128887952698256 0.07870808884232061 0.017516343751080393 0.005242498061433367 0.03416401798892604 1.089376967563044e-07 6.962821811150291 -0.9407987720000561 down EDLNCQEEEDPMNK(ub)LK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 EDLNCQEEEDPMNKLK 16 1 O75821;K7EL20;K7ENA8 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 1 126160700.0 70663000.0 42321500.0 13176200.0 True False 91474646.47597113 39966271.32141157 10778266.799228925 1.0 0.4369109131447701 0.11782791423042227 26.446868599172195 -8.57136484809199 0.334230612431418 1.1531303809683926 3.31584393116889e-23 0.9982062142600704 0.015446539008905741 0.20931223147621808 0.0989584930700555 0.12290306143806043 0.08959725558414236 2.683089451834158e-09 8.57136484809199 -1.1531303809683926 EDLPAENGETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDLPAENGETK 11 0 A6NEL0;P05114;A6NL93 A6NEL0 HMGN1 Non-histone chromosomal protein HMG-14 0 3079700.0 791580.0 496220.0 1791900.0 False True 766451.7261889854 694363.2337531142 1322547.6341522809 1.0 0.9059451626597339 1.7255459006248985 19.547835403201578 -6.878346174966641 1.0890191247038987 0.942893185525027 1.7818107889151784 0.9723250810347726 0.06092241252684584 0.1291033530852759 0.28124542246918904 0.04315700005303425 0.10393686394025925 1.3232863267169634e-07 6.878346174966641 0.8389176033901514 EDLPAENGETK(ub)TEESPASDEAGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDLPAENGETKTEESPASDEAGEK 24 1 A6NEL0;P05114;A6NL93 A6NEL0 HMGN1 Non-histone chromosomal protein HMG-14 1 13475200.0 5195400.0 5024500.0 3255300.0 True False 5030474.870818175 7030809.052421353 2402639.273093321 1.0 1.397643211221893 0.4776167926076026 22.262263164471758 -6.7892462787425965 1.4993761628332265 1.2224598293271314 0.4680381541962473 0.7988665192632205 0.16896369038608097 0.2364750568304857 1.0502662671332363 0.0887042250808476 0.20778997023597487 1.6246272045212875e-07 6.7892462787425965 -0.7544216751308841 down EDLPAENGETK(ub)TEESPASDEAGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDLPAENGETKTEESPASDEAGEK 24 1 A6NEL0;P05114;A6NL93 A6NEL0 HMGN1 Non-histone chromosomal protein HMG-14 1 13289600.0 5195400.0 6434000.0 1660200.0 True False 4320205.295244766 6399338.764950987 2007340.1441025021 1.0 1.4812580253986345 0.46463998975048104 22.042668439906034 -6.777968036974494 1.5436539055609735 1.2732229410468536 0.45707702214292 0.7601590759706776 0.2033521309447748 0.25375555391029336 1.1941663185066649 0.10376859218547137 0.24528311167380143 1.667369922436787e-07 6.777968036974494 -0.8161459189039336 down EDLQELNDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDLQELNDR 9 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 8791860.0 2117600.0 784860.0 5889400.0 False True 2050377.9471156357 1098258.6909908305 4346789.46178718 1.0 0.5356371943698494 2.1199942517436923 20.967458436212027 -6.82823548626226 1.335746262727915 0.7515558858253282 2.1611214394841554 0.9023073009144477 0.2078560362913753 0.1829966965884681 0.6391751927992085 0.12220021494620392 0.2812489076126352 1.485130146028787e-07 6.82823548626226 1.4095655536588272 up EDLQLDKPASGVK(ub)EEWYAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDLQLDKPASGVKEEWYAR 19 2 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 7914100.0 2680500.0 2696400.0 2537200.0 True False 3514161.457998929 2294107.630484878 2274674.882540951 1.0 0.6528179362001235 0.6472880969550615 21.744749046755608 EDLQLDKPASGVK(ub)EEWYAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDLQLDKPASGVKEEWYAR 19 2 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 11147800.0 4326100.0 3172300.0 3649400.0 True False 4188770.323487412 4439015.933325953 2693512.660346744 1.0 1.0597420222434626 0.643031833290928 21.99809535058045 -6.870534547561917 1.1311966025579703 1.0339033077433002 0.6183708924975172 0.9652172140452615 0.03431281542746956 0.136346855040503 0.3257483593090276 0.02353227564031246 0.055768744707563836 1.347303544834489e-07 6.870534547561917 -0.415532415245783 EDLQLDKPASGVK(ub)EEWYAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDLQLDKPASGVKEEWYAR 19 2 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 40468800.0 6918900.0 6440900.0 27109000.0 True False 10496477.139344487 5291471.072018614 21750894.267703183 1.0 0.504118763064259 2.0722089877348644 23.323401871494376 -6.821670582889201 1.364596714227247 0.7331645363432907 2.1076941184896363 0.8881904732968731 0.21882585828554033 0.19131872689069934 0.6995648302644247 0.1259987269859797 0.29029030150839263 1.5077502776260797e-07 6.821670582889201 1.3745295821463457 up EDLQLDKPASGVK(ub)EEWYAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDLQLDKPASGVKEEWYAR 19 2 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 9209800.0 2680500.0 4178300.0 2351000.0 True False 3671553.2877887855 3993688.890209614 1795742.2203648668 1.0 1.087738234248763 0.4890960527080796 21.8079591082785 -6.869652612849665 1.1358680687776925 1.0495236863482336 0.4542577280541179 0.9643385406334307 0.04984761449924849 0.13719174660933423 0.3310287542561327 0.0340640788617275 0.08060367977310928 1.3500423341159648e-07 6.869652612849665 -0.5952659582941157 down EDLQLDKPASGVK(ub)EEWYAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDLQLDKPASGVKEEWYAR 19 2 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 11093500.0 4326100.0 3852100.0 2915300.0 True False 3597343.828725098 3831347.9727180125 3524875.751175777 1.0 1.0650491460183402 0.9798551150516508 21.778500626014726 -6.702616196232665 1.8213525970750497 1.0402882039045238 0.9800940434251278 0.43010161963805504 0.02744504120507057 0.3900980859112709 2.517612674645712 0.012012664677065587 0.030796160678663375 1.9832789561622678e-07 6.702616196232665 -0.060194160479395964 EDLQLDKPASGVK(ub)EEWYAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDLQLDKPASGVKEEWYAR 19 2 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 61077000.0 6918900.0 8851100.0 45307000.0 True False 8956652.441908747 8358528.504257793 37061590.88907763 1.0 0.9332201465301596 4.137884229565958 23.094528193586825 -6.902141531388011 0.9476230660383594 0.8744773982084267 4.4892973254288036 0.987602154406522 0.16648413259742512 0.10984627836728769 0.1686598712707021 0.13121481041248217 0.3452196581353649 1.2527328577261802e-07 6.902141531388011 3.6148199272203767 up EDLRLPEGDLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDLRLPEGDLGK 12 1 I3L397;I3L504;P63241;P63241-2 I3L397 EIF5A Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1 0 23130580.0 6423900.0 4046680.0 12660000.0 False True 6219976.8107650755 5662540.427157421 9343966.208141008 1.0 0.9103796685153416 1.5022509717350012 22.56847777105359 -6.868308363676634 1.142938452339676 0.9497923165750572 1.5358274703455252 0.9629691139058516 0.05012322546392194 0.13849082993568534 0.33916830809854165 0.034067123743060077 0.08043084817566666 1.354227523854063e-07 6.868308363676634 0.586035153770468 EDLRLPEGDLGK(ub)EIEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDLRLPEGDLGKEIEQK 17 2 I3L397;I3L504;P63241;P63241-2 I3L397 EIF5A Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1 1 108792000.0 36605000.0 48814000.0 23373000.0 True False 47989509.4833242 41531141.47548171 20954586.16964746 1.0 0.8654212539912145 0.43664930930225354 25.516215731077015 -6.950091491800279 0.5578463187670712 1.0056722609924291 0.2759825085218991 0.9992083875878218 0.006758537870824026 0.08344919387112854 0.03581166531467623 0.007263756727563531 0.03562606591458948 1.1217821062011438e-07 6.950091491800279 -0.72968975247053 down EDLRLPEGDLGK(ub)EIEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDLRLPEGDLGKEIEQK 17 2 I3L397;I3L504;P63241;P63241-2 I3L397 EIF5A Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1 1 92614000.0 37179000.0 14689000.0 40746000.0 True False 35998772.99575566 20554394.302123062 30073400.24620174 1.0 0.5709748580749259 0.8354007024002587 25.101444397902423 -10.39843837528168 5.912974068669057 1.0000823120634934 0.7031877802375922 0.6268577047852701 0.10795139890028149 0.0001171707914444001 1.1920512677173673e-05 0.10455234676221295 0.03484116417838191 3.99541250654526e-11 10.39843837528168 -0.2968945318259012 EDLRLPEGDLGK(ub)EIEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDLRLPEGDLGKEIEQK 17 2 I3L397;I3L504;P63241;P63241-2 I3L397 EIF5A Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1 1 306740000.0 78013000.0 119307000.0 109420000.0 True False 118351424.51425536 98015733.70015427 87793089.03951026 1.0 0.828175360815774 0.7418000197279894 26.818501829998496 -13.999999999998883 0.08902862234472358 1.883607736065816 0.521999412327429 0.9998469406567103 0.0013276776458514593 12.172426156633472 0.08645439450349665 2.042460110589693 0.19766107719956735 1.0000000000025728e-14 13.999999999998883 -1.3616083237383871 EDLRLPEGDLGK(ub)EIEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDLRLPEGDLGKEIEQK 17 2 I3L397;I3L504;P63241;P63241-2 I3L397 EIF5A Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1 1 103419000.0 36605000.0 37184000.0 29630000.0 True False 50138857.712929755 35541087.92895535 22632004.24900513 1.0 0.7088531639959968 0.4513865149977043 25.579425792599906 -7.0487080279497984 0.1930258969389926 1.1726834888228945 1.9453122780943388e-11 0.9999955756882762 0.00047136113262008977 0.07254413835747545 0.006318665270666205 0.00936025584431425 0.027545099323305927 8.939062464358986e-08 7.0487080279497984 -1.1726834888034414 down EDLRLPEGDLGK(ub)EIEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDLRLPEGDLGKEIEQK 17 2 I3L397;I3L504;P63241;P63241-2 I3L397 EIF5A Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1 1 111614400.0 37179000.0 55704000.0 18731400.0 True False 30915985.808966614 55403911.49562168 22648049.135791842 1.0 1.7920797298190243 0.7325675873878552 24.8818496733367 -6.706574223452371 1.8072268499146604 1.488638787962535 0.7352768323021591 0.4489237653541973 0.3339614650692537 0.3819931306658189 2.4297736525634828 0.14717065433180584 0.3754706263082748 1.9652860730589266e-07 6.706574223452371 -0.7533619556603758 EDLRLPEGDLGK(ub)EIEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDLRLPEGDLGKEIEQK 17 2 I3L397;I3L504;P63241;P63241-2 I3L397 EIF5A Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1 1 551508000.0 78013000.0 131285000.0 342210000.0 True False 100989366.36613145 123978874.34120987 279931291.37111855 1.0 1.227642857880019 2.771888778430819 26.589628152090945 -6.933296947571503 0.7192210538293737 0.9791461815828283 3.117276265097001 0.9971473802251809 0.04204033987194168 0.09096174748451556 0.06955771220911071 0.03908153824532056 0.13728265307577658 1.1660120871110303e-07 6.933296947571503 2.1381300835141728 up EDLTEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDLTEIR 7 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 18305800.0 6076200.0 2221600.0 10008000.0 False True 5883314.356943727 3108696.465490949 7386604.566435638 1.0 0.5283920383791729 1.2555175736475253 22.488197693640547 -6.731648032104919 1.7174124903991204 0.7167097011613476 1.2552020584400834 0.5668279666827474 0.1982277247714233 0.3331460418155418 1.9258114702782723 0.09144374402639757 0.22647272466195392 1.855034401092589e-07 6.731648032104919 0.5384923572787358 EDLVEK(ub)NER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDLVEKNER 9 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 19166100.0 8775700.0 8242300.0 2148100.0 True False 11505027.683999691 7012580.968233764 1925835.218030197 1.0 0.6095231720290707 0.16739075045499463 23.455761119266022 -7.582586765426125 0.41351248169393173 1.0364829871183985 9.781410743439552e-23 0.9984514100710756 0.013384809827281538 0.12036053337721894 0.05759665804938853 0.022814446429441405 0.07095906647572094 2.614648029081191e-08 7.582586765426125 -1.0364829871183985 down EDLVEK(ub)NER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDLVEKNER 9 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 21962400.0 8231900.0 9621800.0 4108700.0 True False 7970582.840414236 13463834.917024137 3032508.211642099 1.0 1.6891907639121173 0.38046254237092875 22.926253792941548 -6.763604937508654 1.5987494387805996 1.3985182732336434 0.374783780432174 0.7055726590412966 0.290046643573348 0.27689928076471343 1.395642986351096 0.14308520355209992 0.3426644000166602 1.7234356112000254e-07 6.763604937508654 -1.0237344928014696 EDLVEK(ub)NER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDLVEKNER 9 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 32889600.0 18990000.0 8130100.0 5769500.0 True False 28809218.35496277 6679220.134238761 4629155.796138315 1.0 0.2318431570042294 0.16068314450957263 24.780027182372745 -13.999999999999998 0.33659705963775094 9.702388146458967 0.149033665215658 0.9997283661060375 0.00626285410984463 19.395969558110377 0.1858971890917287 119.89583365367109 0.022256607990618932 1.0000000000000041e-14 13.999999999999998 -9.553354481243309 EDLVEK(ub)NER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDLVEKNER 9 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 16929900.0 8775700.0 5768000.0 2386200.0 True False 12020313.444375308 5513150.687774711 1822628.7053316259 1.0 0.4586528224315558 0.15162904975531172 23.518971180788913 -8.624325401592882 0.2982072646577754 1.1946752745534899 1.0948598321994726e-16 0.9987351720025812 0.012473225235038294 0.229615611633044 0.08759952097807562 0.1418441125312072 0.0977175881105514 2.3750600707372747e-09 8.624325401592882 -1.1946752745534899 EDLVEK(ub)NER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDLVEKNER 9 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 20912000.0 8231900.0 10687000.0 1993100.0 True False 6845189.585003152 10629427.009796582 2409847.9949468146 1.0 1.5528316459027174 0.3520498541379267 22.706659068375824 -6.781515306249243 1.5298893150138941 1.3124115617313248 0.34206929311946405 0.7727355621574415 0.23394185154551586 0.2482300379545377 1.1476592773856569 0.12042460812997481 0.28380293720798133 1.6538064970850268e-07 6.781515306249243 -0.9703422686118608 down EDLVEK(ub)NER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDLVEKNER 9 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 30758300.0 18990000.0 7993000.0 3775300.0 True False 24582929.34886285 7548182.52358832 3088234.137849226 1.0 0.30704975865447387 0.12562514800507615 24.551153504465194 -13.99998435785841 0.1907304621165446 4.733091110271291 3.5231963819534134e-08 0.9994789911045464 0.008600092840314332 12.476875633080063 0.1397755568594372 17.313148183721495 0.1232114749862615 1.0000360180106826e-14 13.99998435785841 -4.733091075039327 EDLVNK(ub)MCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDLVNKMCR 9 1 P56282;P56282-2;P56282-3 P56282 POLE2 DNA polymerase epsilon subunit 2 1 2754900.0 0.0 0.0 2754900.0 True False 0.0 0.0 2253536.46766107 0.0 EDLVVAPAGITLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDLVVAPAGITLK 13 0 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 8253600.0 1481000.0 3174900.0 3597700.0 False True 1941605.3420244032 2701217.295663267 3225444.5155752664 1.0 1.3912288131875754 1.661225608399015 20.88881855228181 -7.499199824751242 0.08075806808829468 5.651658728058256e-16 2.917605535801897 0.999998889209672 0.00028603636492714057 0.13488855241618972 0.006972113222106752 0.10551427390762563 0.14073989584267374 3.168109437739714e-08 7.499199824751242 2.9176055358018966 EDLVVAPAGITLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDLVVAPAGITLK 13 0 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 7150800.0 3061800.0 1080100.0 3008900.0 False True 2964604.8349445886 1511389.5626470898 2220778.824934874 1.0 0.5098114746464478 0.74909775453307 21.499408383822328 -10.147506612129868 5.055605606982152 1.0000181539317028 0.6294546145891544 0.7617526761402974 0.09768821469727398 1.9989872314792185e-05 3.370603386105178e-06 0.09459083722383446 0.031528735719971654 7.120219593882795e-11 10.147506612129868 -0.3705635393425484 EDLVVAPAGITLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDLVVAPAGITLK 13 0 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 9565400.0 1481000.0 5353900.0 2730500.0 False True 2028565.722520123 5117346.995020284 2085612.1364127079 1.0 2.522642938412128 1.028121550738674 20.9520286138047 -6.641829346039388 2.0376179442697984 1.994326059594798 1.0343296209577733 0.16173263298392515 0.6511942786950354 0.5287818220711803 4.198109146791063 0.2600370538483126 0.7212005040190886 2.2812382976942276e-07 6.641829346039388 -0.9599964386370248 EDLVVAPAGITLK(ub)EANEILQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDLVVAPAGITLKEANEILQR 21 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 19971800.0 7053800.0 0.0 12918000.0 True False 10701130.301855508 0.0 10364751.63783946 1.0 0.0 0.9685660622263685 23.35125985287148 -11.90455453472255 17.307672366401693 0.8591077958022083 0.5358547280018878 0.0 0.47951719531438036 0.0 0.0 0.0 0.13655617257736063 1.2457917923276679e-12 11.90455453472255 -0.3232530678003205 EDLYLK(ub)PIQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDLYLKPIQR 10 1 P13639 P13639 EEF2 Elongation factor 2 1 18169670.0 2635770.0 7839700.0 7694200.0 True False 3455519.994832989 6670047.31891126 6898077.991977987 1.0 1.930258638029856 1.9962489009736963 21.7204713964409 -11.004656083831824 0.4705424924352941 1.3710105062760157e-20 1.995361498543215 0.9997193958220844 0.007619814746548919 2.8178206382241813 0.2287077324265348 3.064490408001207 0.01421935690739684 9.893362361801851e-12 11.004656083831824 1.995361498543215 EDLYLK(ub)PIQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDLYLKPIQR 10 1 P13639 P13639 EEF2 Elongation factor 2 1 22908100.0 1923100.0 2848400.0 18136600.0 True False 1862052.2431517204 3985780.97420977 13386080.373662723 1.0 2.1405312277723283 7.188885501410726 20.82846212013633 -6.942555662954947 0.6353422408196515 0.9448716126158794 8.659126684902777 0.9984798579089693 0.10485149410261206 0.08661980888544776 0.04944362554600587 0.10416225362802956 0.4298484475846002 1.1414170013211563e-07 6.942555662954947 7.714255072286898 EDLYLK(ub)PIQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDLYLKPIQR 10 1 P13639 P13639 EEF2 Elongation factor 2 1 103285600.0 11223600.0 29050000.0 63012000.0 True False 17027021.755068973 23865800.531314045 50557650.58085929 1.0 1.4016426874071009 2.969259762988685 24.021322775390963 -6.945438823768895 0.6068578904558553 0.9825756758896752 3.4695242518072695 0.9987929771917659 0.029517779836019994 0.08537063936083122 0.043952502165744256 0.030094072582195906 0.1320412372873949 1.1338645469599992e-07 6.945438823768895 2.4869485759175944 up EDLYLK(ub)PIQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDLYLKPIQR 10 1 P13639 P13639 EEF2 Elongation factor 2 1 14678570.0 2635770.0 1898900.0 10143900.0 True False 3610285.3980059824 1815000.319177425 7748119.740178291 1.0 0.502730426846553 2.1461238893904895 21.78368145796379 -6.825556923713752 1.3477644811680416 0.7333775451625116 2.186428260437191 0.8966677160479866 0.22119946545683566 0.18636027395546167 0.6636115226103289 0.12892197424386279 0.29678200682793304 1.4943181667152937e-07 6.825556923713752 1.4530507152746797 up EDLYLK(ub)PIQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDLYLKPIQR 10 1 P13639 P13639 EEF2 Elongation factor 2 1 20803100.0 1923100.0 6694100.0 12185900.0 True False 1599142.85777519 6658037.554625178 14733915.34876443 1.0 4.163503918523066 9.213632964138686 20.608867395570606 -6.964201732932473 0.3714978632508085 0.6181765826325832 12.935162179966387 0.9998957327009501 0.03453976597677217 0.07823289125352116 0.015821494093190634 0.06641680184943832 0.42856211165654445 1.0859210882350709e-07 6.964201732932473 12.316985597333803 EDLYLK(ub)PIQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDLYLKPIQR 10 1 P13639 P13639 EEF2 Elongation factor 2 1 76870900.0 11223600.0 23256300.0 42391000.0 True False 14529171.450231532 21962066.46106928 34676272.96839101 1.0 1.5115842315095882 2.3866655498678435 23.792449097483413 -6.962983098364594 0.39112676131245294 0.9469258214611048 2.982823326633944 0.9998653429021899 0.006643979590138492 0.07865221576144824 0.017316002149212768 0.01129144280455663 0.07357529596058211 1.088972472544599e-07 6.962983098364594 2.0358975051728394 EDLYLKPIQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDLYLKPIQR 10 1 P13639 P13639 EEF2 Elongation factor 2 0 47251770.0 750770.0 25753000.0 20748000.0 False True 984266.7404670218 21910752.78440776 18601195.98886946 1.0 22.260990729008473 18.898531489587295 19.908689819472507 -9.608114808814584 8.413275754491114 1.0000086924736047 20.579761109297948 0.9783599037318359 1.3727182362575272 0.0 0.0 1.329128538762425 0.44304290567030125 2.465387508474526e-10 9.608114808814584 19.579752416824345 EDLYLKPIQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDLYLKPIQR 10 1 P13639 P13639 EEF2 Elongation factor 2 0 24646200.0 5497500.0 3668700.0 15480000.0 False True 5322984.871679353 5133631.04201776 11425323.609954404 1.0 0.9644271336052372 2.146412940367764 22.34380403534632 -6.899960029622758 0.9615086149129041 0.9508034333336113 2.270386785576825 0.9865467563702722 0.06367758836556778 0.11143511692684552 0.17758068697779394 0.04967365453648995 0.12921816275525858 1.259041282571693e-07 6.899960029622758 1.3195833522432139 up EDLYLKPIQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDLYLKPIQR 10 1 P13639 P13639 EEF2 Elongation factor 2 0 42355770.0 750770.0 14917000.0 26688000.0 False True 1028349.9577963747 14257917.616077557 20384844.056613196 1.0 13.864849711892331 19.822866624408064 19.971899880995398 -8.565107432620417 0.46321647516830156 4.03734058884882e-19 20.505845398476268 0.9952863791084045 0.5392882227907788 0.23610860562905403 0.15919304642289558 1.796136510374478 1.322671228024535 2.7220278692657992e-09 8.565107432620417 20.505845398476268 EDMAALEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDMAALEK 8 0 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 40182000.0 9546100.0 3948900.0 26687000.0 False True 9243064.280770956 5525716.363241459 19696874.107161086 1.0 0.5978229941272857 2.130989627340143 23.13993978566148 -6.836988478730864 1.29623437165234 0.7858958475692824 2.178507136322156 0.9191661308067293 0.18453554483840762 0.17234299172466508 0.5637867744605268 0.11168149352189294 0.2571325323083816 1.4554976925351716e-07 6.836988478730864 1.3926112887528737 up EDPNWWQASHVK(ub)EGGSAGLIPSQFLEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDPNWWQASHVKEGGSAGLIPSQFLEEK 28 1 B8ZZG1;Q9NZW5;C9J4Q3 B8ZZG1 MPP6 MAGUK p55 subfamily member 6 1 30900100.0 12640000.0 12510000.0 5750100.0 True False 12238750.118786182 17505308.23878815 4243976.310697603 1.0 1.4303182979377878 0.3467655005214301 23.544952894668455 -6.7989538342339575 1.4602328526192043 1.2377426607972457 0.3322006618904275 0.8290682715688165 0.1841738105741712 0.22225710205378568 0.9357373788053659 0.09922924926675163 0.23091388593331091 1.588715621053206e-07 6.7989538342339575 -0.9055419989068182 down EDPNWWQASHVK(ub)EGGSAGLIPSQFLEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDPNWWQASHVKEGGSAGLIPSQFLEEK 28 1 B8ZZG1;Q9NZW5;C9J4Q3 B8ZZG1 MPP6 MAGUK p55 subfamily member 6 1 72245000.0 35641000.0 21106000.0 15498000.0 True False 54070002.7061204 17339469.398069344 12434813.506985286 1.0 0.32068556556788597 0.2299761953882377 25.688325092836116 -13.999999999999998 0.2837618117732032 6.652795952645807 0.20366627480488217 0.9996135300783525 0.0067550423402895675 15.605482558149284 0.16880700206777932 51.30768497256162 0.035253068695263415 1.0000000000000041e-14 13.999999999999998 -6.449129677840925 EDPNWWQASHVK(ub)EGGSAGLIPSQFLEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDPNWWQASHVKEGGSAGLIPSQFLEEK 28 1 B8ZZG1;Q9NZW5;C9J4Q3 B8ZZG1 MPP6 MAGUK p55 subfamily member 6 1 25790900.0 12640000.0 8490200.0 4660700.0 True False 10510720.046944188 8444461.607427252 5635230.82135799 1.0 0.8034141875829273 0.5361412725473872 23.32535817010273 -6.966839162585238 0.32494312212462007 1.0345433492404674 0.29632817864056643 0.9999461905428377 0.0013944730271833357 0.07734227952769893 0.01268828524720583 0.003973344319036739 0.023409649720621678 1.0793463753368895e-07 6.966839162585238 -0.7382151705999009 EDPNWWQASHVK(ub)EGGSAGLIPSQFLEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDPNWWQASHVKEGGSAGLIPSQFLEEK 28 1 B8ZZG1;Q9NZW5;C9J4Q3 B8ZZG1 MPP6 MAGUK p55 subfamily member 6 1 87672800.0 35641000.0 31944000.0 20087800.0 True False 46137977.08914267 30166288.31896724 16432026.51823369 1.0 0.6538277189891375 0.3561496960841078 25.459451414928566 -7.477116244637053 0.23196794819111566 1.1519615835179748 2.5620137165341752e-15 0.9999125704434314 0.0024600699587119246 0.12568430896451901 0.02138580341078057 0.02698053528073204 0.0632795962402055 3.33337178736024e-08 7.477116244637053 -1.1519615835179722 down EDPTVSALLTSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDPTVSALLTSEK 13 0 Q5TA02;P78417-3;P78417;Q5TA01;P78417-2 Q5TA02 GSTO1 Glutathione S-transferase omega-1 0 7438700.0 1997500.0 2308100.0 3133100.0 False True 2618741.8438175153 1963740.4769033338 2808916.8668173775 1.0 0.7498793672768668 1.0726207600221607 21.320442414808298 -6.69981494958722 1.8316362730646463 0.8446572495382603 1.0716544177804663 0.4166793615492381 0.1055824490400966 0.3958921260349358 2.582061524945085 0.045990492101576755 0.11829774323272156 1.9961126660640474e-07 6.69981494958722 0.22699716824220606 EDQCPLQVALPAEK(ub)AEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDQCPLQVALPAEKAEGR 18 1 Q969F2-2;Q969F2 Q969F2-2 NKD2 Protein naked cuticle homolog 2 1 11535400.0 3591400.0 4339100.0 3604900.0 True False 4708360.179167071 3691723.1936793295 3231899.5286425464 1.0 0.7840783315630732 0.686417225033596 22.166793256910054 -13.999999999999966 0.10700322557644518 2.0478350205989804 0.49927719638311596 0.9997582960167264 0.002036923578530318 12.03111338661014 0.09875928644521437 2.739536595167617 0.16636770191077965 1.0000000000000778e-14 13.999999999999966 -1.5485578242158644 EDQCPLQVALPAEK(ub)AEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDQCPLQVALPAEKAEGR 18 1 Q969F2-2;Q969F2 Q969F2-2 NKD2 Protein naked cuticle homolog 2 1 13669300.0 5273800.0 4606500.0 3789000.0 True False 5106386.105732175 6445899.47258016 2796547.2324365135 1.0 1.2623212070360905 0.54765683098214 22.283871196721627 -6.807369283072814 1.4257277143631304 1.14341132240532 0.5359100709045765 0.8528128047775307 0.11324509628319869 0.2104055506321117 0.8434476082896797 0.06246741839486475 0.1446688558922761 1.5582269700804927e-07 6.807369283072814 -0.6075012515007434 EDQCPLQVALPAEK(ub)AEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDQCPLQVALPAEKAEGR 18 1 Q969F2-2;Q969F2 Q969F2-2 NKD2 Protein naked cuticle homolog 2 1 11462000.0 3591400.0 4497700.0 3372900.0 True False 4919237.633935693 4298976.742095055 2576290.487056002 1.0 0.8739111752679468 0.5237174291567637 22.230003318432946 -6.953170497159612 0.5228831657679153 1.0058208729458815 0.3761027048307239 0.9994271600929051 0.004822441199592931 0.08223712593997895 0.030883128491180693 0.005438472918181191 0.028934752672854683 1.113857165001124e-07 6.953170497159612 -0.6297181681151576 EDQCPLQVALPAEK(ub)AEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDQCPLQVALPAEKAEGR 18 1 Q969F2-2;Q969F2 Q969F2-2 NKD2 Protein naked cuticle homolog 2 1 10951900.0 5273800.0 3484200.0 2193900.0 True False 4385398.368953668 3465429.9230404487 2652634.346552516 1.0 0.7902200966675877 0.6048787643402668 22.064276472155903 -6.972584616739854 0.1863881500030685 1.1316998110347314 0.25835467653689503 0.9999961515326085 0.000316594359625252 0.07547265811727448 0.0059211022761807754 0.00674946308786923 0.020410882093891896 1.0651613103547439e-07 6.972584616739854 -0.8733451344978364 EDQSILCTGESGAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDQSILCTGESGAGK 15 0 P35579;P35579-2;Q5BKV1;P35749-2;P35749;P35749-3;P35749-4;A0A494C024;A0A2R8Y4C3;E7ERA5;Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4;M0QY43;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;Q7Z406;P35580 MYH9;MYH11;MYH10;MYH14 Myosin-9;Myosin-11;Myosin-14;Myosin-10 0 8358780.0 3684700.0 878680.0 3795400.0 False True 3567731.2154028094 1229541.5062556663 2801270.8804406286 1.0 0.34462840164287617 0.7851687000261748 21.766575499377215 -9.851588283217366 5.577122026741983 1.0000001713003523 0.5648985508323837 0.565333478117153 0.17984982370379668 3.829783919515904e-07 7.909606732818753e-08 0.17413891306279258 0.05804628100071213 1.4073811073848866e-10 9.851588283217366 -0.43510162046796863 EDQTEYLEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDQTEYLEER 10 0 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 4 0 205410000.0 6822000.0 122920000.0 75668000.0 False True 8943708.064341968 104580815.13840716 67838601.21870896 1.0 11.693227729040558 7.585064352578483 23.092441666606362 -9.742117182361746 10.052514638420051 0.9999999981012229 9.639146040809521 0.8549962438719995 1.6771506753868934 0.0 0.0 1.62389415871349 0.5412980529044965 1.8108514184928536e-10 9.742117182361746 8.639146042708298 EDQTEYLEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDQTEYLEER 10 0 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 4 0 215955000.0 57393000.0 15572000.0 142990000.0 False True 55571090.63033987 21789980.806907214 105536629.39194974 1.0 0.39211000827488973 1.8991282732595938 25.72783121890596 -6.797238961146962 1.4673445316307765 0.6634095955047018 1.91849424455667 0.8238931911204087 0.25978709165368424 0.22473711409220282 0.9555916179335193 0.13930524401244443 0.32450618588066177 1.5950012907800852e-07 6.797238961146962 1.2550846490519683 EDQTEYLEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDQTEYLEER 10 0 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 4 0 157532000.0 6822000.0 72284000.0 78426000.0 False True 9344277.757617997 69090253.8687772 59903394.034170605 1.0 7.393857038597854 6.4107034902011435 23.155651728129254 -9.364180752083211 12.09155431811999 0.9999999999999953 6.902280264399499 0.9796145852103627 0.401370755396438 0.0 0.0 0.3886255628262737 0.12954185427542453 4.3233385750826386e-10 9.364180752083211 5.902280264399503 EDQTEYLEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDQTEYLEER 10 0 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 4 0 62213700.0 57393000.0 2796500.0 2024200.0 False True 47724822.441002235 2781434.6994382134 2447450.8611566606 1.0 0.05828067150750833 0.05128255561730411 25.508236494340235 EDSDEVHLEELSLSK(ub)EGPGPEDTVQDNLGAAGAEEEQEEHQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQK 42 1 P33241;P33241-3;E7EMG9;C9JU59;P33241-2;E9PBD8;C9JKF7 P33241;P33241-2 LSP1 Lymphocyte-specific protein 1 1 78719000.0 47493300.0 23749000.0 7476700.0 True False 45985651.18801809 33232099.54939886 5518327.973807892 1.0 0.7226623673007317 0.12000108362596666 25.454680434311776 -7.275154823869218 0.5864378981124332 1.00229644952841 2.909349310713852e-23 0.9973450751469384 0.018928066859285792 0.0966228286087456 0.06193589571266874 0.018409005058286403 0.057899413155831116 5.3069522024099475e-08 7.275154823869218 -1.00229644952841 down EDSDEVHLEELSLSK(ub)EGPGPEDTVQDNLGAAGAEEEQEEHQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDSDEVHLEELSLSKEGPGPEDTVQDNLGAAGAEEEQEEHQK 42 1 P33241;P33241-3;E7EMG9;C9JU59;P33241-2;E9PBD8;C9JKF7 P33241;P33241-2 LSP1 Lymphocyte-specific protein 1 1 97257800.0 47493300.0 46227500.0 3537000.0 True False 39492783.25993158 45978463.28205969 4276570.346759759 1.0 1.1642244351187152 0.10828738806815531 25.235085709746052 -6.867178454959489 1.1489858788567895 1.0914605778380966 0.04969191789561972 0.961781433293785 0.09069736376363567 0.1395852127064097 0.3461888171163387 0.061362815609548836 0.1446016256347251 1.357755419749504e-07 6.867178454959489 -1.041768659942477 down EDSQRPGAHLTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDSQRPGAHLTVK 13 1 P09651;F8W6I7;P09651-3;F8VZ49;Q32P51;F8W646;F8VYN5;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 367640000.0 102840000.0 119190000.0 145610000.0 False True 134824235.90397677 101407316.59898102 130543673.98974761 1.0 0.7521445674737914 0.9682507978960265 27.00650461671398 -10.202871841260853 6.822187126977364 1.0000005097496627 0.8601976828091429 0.35815078830732616 0.08822499912846718 6.840634727995656e-07 7.9858422353928e-08 0.08542379994416564 0.02847449602864311 6.267988034554722e-11 10.202871841260853 -0.13980282694051982 EDSQRPGAHLTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDSQRPGAHLTVK 13 1 P09651;F8W6I7;P09651-3;F8VZ49;Q32P51;F8W646;F8VYN5;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 214901000.0 52155000.0 37186000.0 125560000.0 False True 50499368.07320361 52034563.72242826 92672069.28074144 1.0 1.0304002942571329 1.8351134443188382 25.589761998940137 -6.914885295179894 0.8618150645421097 0.978764849190591 1.9507499336041865 0.9926376165375861 0.0331813963408792 0.10127646554711267 0.12190522423357485 0.027839791186547603 0.07971713813031973 1.2165072592079553e-07 6.914885295179894 0.9719850844135954 EDSQRPGAHLTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDSQRPGAHLTVK 13 1 P09651;F8W6I7;P09651-3;F8VZ49;Q32P51;F8W646;F8VYN5;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 692236000.0 66853000.0 554620000.0 70763000.0 False True 101420888.60896927 455643727.7341609 56776662.03347535 1.0 4.492602401571401 0.559812310976481 26.595779578984228 -6.6723931790053115 1.9288540477321838 3.2246918142896805 0.5755140470730135 0.2897306333145575 1.4827641320845741 0.4556307043369283 3.2703527338655127 0.6183639579210471 1.6469963711454911 2.1262132537370124e-07 6.6723931790053115 -2.649177767216667 EDSQRPGAHLTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDSQRPGAHLTVK 13 1 P09651;F8W6I7;P09651-3;F8VZ49;Q32P51;F8W646;F8VYN5;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 379183000.0 102840000.0 97403000.0 178940000.0 False True 140862727.146502 93099413.39135219 136678057.38498074 1.0 0.660922979962795 0.9702925688981653 27.06971467823687 -10.383495216371363 8.190161889741285 1.000001646147156 0.8156077750486446 0.3214184261456121 0.12629960580437294 3.796370637616565e-06 2.859078877197417e-07 0.12229015889541162 0.0407630224927415 4.1352786921289924e-11 10.383495216371363 -0.18439387109851135 EDSQRPGAHLTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDSQRPGAHLTVK 13 1 P09651;F8W6I7;P09651-3;F8VZ49;Q32P51;F8W646;F8VYN5;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 112325000.0 52155000.0 38185000.0 21985000.0 False True 43369193.358257465 37979289.825870894 26581961.852845177 1.0 0.8757204569644057 0.6129226714746815 25.370167274374413 -6.958940779978932 0.45011269351192956 1.0084649233134855 0.46975812510012455 0.9997288750349675 0.002656946754574413 0.08008167128321837 0.0225458503508514 0.0035131483241069776 0.02173734660443261 1.0991557091389522e-07 6.958940779978932 -0.5387067982133609 EDSQRPGAHLTVK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDSQRPGAHLTVKK 14 2 P09651;F8W6I7;P09651-3;F8VZ49;Q32P51;F8W646;F8VYN5;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 1 49220000.0 10665000.0 21540000.0 17015000.0 True False 13981918.280006915 18326315.962262373 15254451.019404931 1.0 1.3107154251121333 1.091012743309882 23.737058972220893 -10.25689459375214 3.9421285563891177 0.9997646401573207 1.2008640840909017 0.5270706664408267 0.0896932443618547 31702055.104919672 27.498661177424758 68001.32373414762 0.03070438323017676 5.5348442737978587e-11 10.25689459375214 0.20109944393358103 EDSQRPGAHLTVK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDSQRPGAHLTVKK 14 2 P09651;F8W6I7;P09651-3;F8VZ49;Q32P51;F8W646;F8VYN5;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 1 68821000.0 22030000.0 21921000.0 24870000.0 True False 21330669.708612315 30674169.616504814 18355800.915992662 1.0 1.438031249629262 0.8605356121838715 24.346425926192236 -6.703839429784646 1.8168070612307603 1.2709586249344904 0.8621007122708073 0.4360356482522557 0.18477033637356868 0.3875624449165003 2.4895509046440103 0.08104768914685397 0.20747972555936717 1.9777007134843716e-07 6.703839429784646 -0.4088579126636831 EDSQRPGAHLTVK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDSQRPGAHLTVKK 14 2 P09651;F8W6I7;P09651-3;F8VZ49;Q32P51;F8W646;F8VYN5;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 1 65557000.0 12409000.0 14786000.0 38362000.0 True False 18825360.21941718 12147322.776454711 30779733.88533808 1.0 0.6452637630766559 1.6350143384555644 24.16617413504737 -6.809769048045397 1.415378144099618 0.8066145895051011 1.652259247260726 0.8592490886499691 0.15360450636923628 0.20711842050180077 0.8177953210742627 0.0853325349322115 0.19742397892375685 1.549640477763658e-07 6.809769048045397 0.8456446577556249 EDSQRPGAHLTVK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDSQRPGAHLTVKK 14 2 P09651;F8W6I7;P09651-3;F8VZ49;Q32P51;F8W646;F8VYN5;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 1 50525000.0 10665000.0 18559000.0 21301000.0 True False 14608138.710788045 17739002.0135941 16270142.507865623 1.0 1.2143232183641524 1.1137724545188084 23.800269033743785 -10.199044638846093 4.200300706261201 0.9999290900703808 1.1640478364530429 0.7801726483756076 0.04104967748355115 28854332.109271206 2.5896166649887347 19789.04049739219 0.014052396454328452 6.323468524280092e-11 10.199044638846093 0.1641187463826621 EDSQRPGAHLTVK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDSQRPGAHLTVKK 14 2 P09651;F8W6I7;P09651-3;F8VZ49;Q32P51;F8W646;F8VYN5;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 1 48543000.0 12409000.0 13426000.0 22708000.0 True False 16063695.117958846 12678831.297597477 18575377.00375605 1.0 0.7892848565970872 1.1563576666111648 23.93730045713982 -6.751009271915985 1.6460457921208616 0.8762521125729436 1.1571480655567576 0.6533870173184118 0.08854835290786262 0.2982582826718075 1.5902711883914542 0.04248967448654685 0.10304694991464257 1.7741516034570086e-07 6.751009271915985 0.2808959529838141 EDSVK(ub)PGAHLTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDSVKPGAHLTVK 13 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 16752700.0 6056300.0 6407300.0 4289100.0 True False 7939867.949292621 5451355.8154597785 3845305.075952385 1.0 0.6865801610649521 0.4843034041006905 22.920683582928568 -8.6001556025171 0.1235442764082968 1.5049984824839966 1.138877310605683e-08 0.9999472664162825 0.0015406201074959125 0.200600709411237 0.03209108094144156 0.1979936393201214 0.16574854278578727 2.510986613859183e-09 8.6001556025171 -1.5049984710952236 EDSVK(ub)PGAHLTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDSVKPGAHLTVK 13 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 29698200.0 9302300.0 9956900.0 10439000.0 True False 9007003.578321593 13932742.094547562 7704712.736712807 1.0 1.5468787120370895 0.8554135312277226 23.10261580392189 -6.695929014426576 1.8457861742559798 1.3409397652256843 0.8576455171796288 0.3981554461819248 0.2310208143776044 0.40402224364032097 2.673210534404292 0.09997032839456171 0.2583590485365333 2.0140534206426338e-07 6.695929014426576 -0.4832942480460555 EDSVK(ub)PGAHLTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDSVKPGAHLTVK 13 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 79377000.0 16444000.0 20654000.0 42279000.0 True False 24946750.217430625 16968132.32956143 33922537.118456036 1.0 0.6801740580103925 1.3597978423159065 24.572348553899822 -6.778720382992918 1.5406803801169229 0.8186064972403447 1.3649836658889465 0.7628941338631929 0.13518058832188112 0.252568069376271 1.184052833702657 0.0691102982764788 0.1632585502041084 1.664483970061661e-07 6.778720382992918 0.5463771686486018 EDSVK(ub)PGAHLTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDSVKPGAHLTVK 13 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 16174100.0 6056300.0 5230500.0 4887300.0 True False 8295477.775353544 4999399.215049512 3733020.3971030256 1.0 0.6026656149815847 0.4500066781197456 22.98389364445146 -13.999999999969646 0.1324813951491441 2.889302811952031 0.24280586607887203 0.9996345306175355 0.004431791888357187 11.933666721844368 0.11342693158720811 5.8585325481782515 0.18445681539699962 1.0000000000698935e-14 13.999999999969646 -2.6464969458731593 EDSVK(ub)PGAHLTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDSVKPGAHLTVK 13 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 28626700.0 9302300.0 11512000.0 7812400.0 True False 7735274.61176338 11449982.571046911 9445936.719543664 1.0 1.4802296163648034 1.2211507921359124 22.883021079356165 -10.146052706042445 4.597534061439822 0.999958421248107 1.3506902042560613 0.7095550047462293 0.10576848710630163 4.5082219925146765e-05 8.373740594707433e-06 0.1024220193281935 0.03413663242360955 7.144096199573294e-11 10.146052706042445 0.3507317830079544 EDSVK(ub)PGAHLTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDSVKPGAHLTVK 13 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 85340000.0 16444000.0 17169000.0 51727000.0 True False 21287082.15969987 16213530.05723605 42313216.76384049 1.0 0.7616605195394542 1.9877415066282185 24.34347487599227 -6.856281799393233 1.2043083456537904 0.8717495261176402 2.043051806412402 0.9489608387432682 0.11991695921329994 0.15068840044063384 0.4174148937555398 0.07776796015626401 0.18084825456223072 1.392253122571637e-07 6.856281799393233 1.1713022802947617 EDSVKPGAHLTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDSVKPGAHLTVK 13 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 87926000.0 19998000.0 40867000.0 27061000.0 False True 26217571.660907507 34769802.898318335 24260987.307441503 1.0 1.3262022641922588 0.925371259444923 24.644030729824365 -6.690304774289781 1.8655419692736588 1.2044509793186418 0.9267589518650358 0.3717895870329462 0.13795211884437142 0.4159960918201921 2.8072622108425316 0.05915471891321867 0.15397197110859817 2.0403056194513962e-07 6.690304774289781 -0.277692027453606 EDSVKPGAHLTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDSVKPGAHLTVK 13 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 55158000.0 14563000.0 11989000.0 28606000.0 False True 14100705.536383169 16776270.221809063 21113230.43839511 1.0 1.189746866106969 1.4973173068480836 23.749264014663677 -6.963936680331564 0.3758587252536343 0.977864073930231 1.7200053990918274 0.9998895144216758 0.0021539444043896456 0.0783237111326065 0.016143978223616465 0.0040214923477700365 0.026042309741041526 1.0865840348524973e-07 6.963936680331564 0.7421413251615964 EDSVKPGAHLTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDSVKPGAHLTVK 13 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 210976000.0 15576000.0 165060000.0 30340000.0 False True 23629930.758130584 135603753.38033357 24343285.70150558 1.0 5.738643704390672 1.0301886175916763 24.49411206605618 -6.644674380025357 2.0274023228520677 4.087707437773048 1.0498134275317035 0.17285574425928596 2.025160674647923 0.5216579659345814 4.103522678964759 0.8118100699172975 2.2429579656522507 2.2663429014417907e-07 6.644674380025357 -3.0378940102413443 EDSVKPGAHLTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDSVKPGAHLTVK 13 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 78847000.0 19998000.0 24250000.0 34599000.0 False True 27391801.02562959 23178554.815973736 26427428.78877248 1.0 0.8461858639483523 0.9647933979969122 24.707240791347257 -10.225578079865494 5.1684938360805255 1.000009394714468 0.9054896310651687 0.45846124941464983 0.048421323011580225 5.2424281374978e-06 7.854903886718936e-07 0.046888404761160976 0.015627914802080926 5.948697981599329e-11 10.225578079865494 -0.09451976364929926 EDSVKPGAHLTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDSVKPGAHLTVK 13 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 29029600.0 14563000.0 9261400.0 5205200.0 False True 12109779.75028863 9211506.999956023 6293583.253874444 1.0 0.7606667660273897 0.5197107943870276 23.529669290097953 -6.971041357184736 0.2319698057326849 1.0956126412843143 0.1778637303179018 0.9999894037525241 0.0006382433603607305 0.0759662209045204 0.007810544846441862 0.006102381458932953 0.02384113373641528 1.068953079644562e-07 6.971041357184736 -0.9177489109664125 EDSVKPGAHLTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDSVKPGAHLTVK 13 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 63907000.0 15576000.0 34028000.0 14303000.0 False True 20163439.0488619 32134311.88698396 11700000.761173293 1.0 1.5936920189613064 0.5802581956788609 24.265238388148628 -6.747885273529705 1.6573396960005053 1.3499672952557926 0.5785200376444296 0.6400093607815798 0.2494522846314206 0.3037212156114583 1.6406679269256406 0.11892562237778508 0.2894007577178134 1.7869595690775227e-07 6.747885273529705 -0.771447257611363 EDSVKPGAHLTVK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDSVKPGAHLTVKK 14 2 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 22416600.0 6857500.0 5356100.0 10203000.0 True False 10403328.850403216 4400262.107599692 8186372.577866244 1.0 0.4229667417875717 0.7868993372778901 23.310541899071524 -10.111497342641435 5.289660648422271 1.0000078848451446 0.6049330395324435 0.6110802493638265 0.14857485995409175 1.3815735067511807e-05 2.320555398452985e-06 0.1438598585688008 0.0479523298554504 7.735754121092166e-11 10.111497342641435 -0.3950748453127011 EDSVKPGAHLTVK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDSVKPGAHLTVKK 14 2 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 15078800.0 4447800.0 7514500.0 3116500.0 True False 3698542.7709492417 7474017.896988531 3768145.7409320837 1.0 2.0208007206768905 1.0188190253008695 21.818525528922002 -6.641821184848998 2.0375347276012494 1.6666050070933363 1.0229690316918845 0.16176468120435283 0.4365683764751165 0.5287848577558495 4.197738088441678 0.17433500980004435 0.4835348326189745 2.281281166751467e-07 6.641821184848998 -0.6436359754014518 EDTEEYNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDTEEYNLR 9 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 18449400.0 4202900.0 1716500.0 12530000.0 False True 4069481.2400511494 2401907.4014292466 9248017.108057419 1.0 0.5902244683646845 2.2725297310723516 21.956413466983808 -6.842324910349554 1.2715904674755496 0.7820421128321339 2.3304496968557005 0.928383980917413 0.19168252903521787 0.16608974263535364 0.5206732757952742 0.11815690692383458 0.2723985012399843 1.437722567062777e-07 6.842324910349554 1.5484075840235665 up EDTNNLFSVQFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDTNNLFSVQFR 12 0 Q5JRX3;Q5JRX3-2;Q5JRX3-3 Q5JRX3 PITRM1 Presequence protease, mitochondrial 0 8650800.0 2916900.0 2262700.0 3471200.0 False True 3824084.1472997796 1925113.979935519 3112033.5221015858 1.0 0.5034183103148657 0.8137983899488772 21.86668283886575 -10.425453977221927 6.242284919041314 1.000088465293189 0.6586083501318735 0.6173103512834092 0.12671213690462296 0.00015604442326146061 1.4362475237069164e-05 0.12272009079965575 0.04089616633282992 3.7544473875464435e-11 10.425453977221927 -0.3414801151613155 EDTNNLFSVQFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDTNNLFSVQFR 12 0 Q5JRX3;Q5JRX3-2;Q5JRX3-3 Q5JRX3 PITRM1 Presequence protease, mitochondrial 0 6226100.0 1396000.0 2134700.0 2695400.0 False True 1351684.744131765 2987096.8423134373 1989393.8797332777 1.0 2.209906455837197 1.4717883651273551 20.366327277813642 -10.285336790854732 5.488629366658049 0.9999698986481159 1.840847410104532 0.6337398814877142 0.3013354514338353 0.00037061772415117057 4.8257230395397424e-05 0.29180119332759613 0.09725559833924306 5.18397870852217e-11 10.285336790854732 0.8408775114564161 EDTNNLFSVQFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDTNNLFSVQFR 12 0 Q5JRX3;Q5JRX3-2;Q5JRX3-3 Q5JRX3 PITRM1 Presequence protease, mitochondrial 0 8171900.0 2916900.0 2380400.0 2874600.0 False True 3995356.756258568 2275226.057069853 2195678.6842453643 1.0 0.5694675584366281 0.5495576035371361 21.92989290038864 EDTNNLFSVQFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDTNNLFSVQFR 12 0 Q5JRX3;Q5JRX3-2;Q5JRX3-3 Q5JRX3 PITRM1 Presequence protease, mitochondrial 0 4916900.0 1396000.0 2100200.0 1420700.0 False True 1160835.8532859248 2088885.8057429388 1717761.8014253862 1.0 1.7994669959839935 1.4797628765195328 20.14673255324792 -10.148909745652317 4.711833899285277 0.9999400332133923 1.639614936174138 0.8421911947325913 0.1305186602532372 8.566970780581625e-05 1.547457160225979e-05 0.12638643454028864 0.042124716456856885 7.097252465437258e-11 10.148909745652317 0.6396749029607456 EDVFVHQTAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDVFVHQTAIK 11 0 P67809;H0Y449;Q9Y2T7;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX2;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 2;Y-box-binding protein 3 0 46868500.0 5869500.0 16776000.0 24223000.0 False True 7694971.340318864 14273086.192335838 21716636.323423237 1.0 1.8548589151398178 2.8221854719114967 22.87548452261491 -6.969518306041945 0.2694427836173541 0.7578994483450251 3.948204033662796 0.999978378059936 0.0034613000379842516 0.07645931457544528 0.009588068188739488 0.019026678562931082 0.09003587608894581 1.0727084309142509e-07 6.969518306041945 3.190304585317771 EDVFVHQTAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDVFVHQTAIK 11 0 P67809;H0Y449;Q9Y2T7;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX2;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 2;Y-box-binding protein 3 0 31846600.0 9052600.0 3890000.0 18904000.0 False True 8765230.168142708 5443297.286082006 13952475.292156205 1.0 0.6210101938755367 1.591797936221524 23.063360544858693 -6.800827306500134 1.452415573379157 0.7911022650285985 1.6054878273072648 0.8345614935789751 0.16248663573168384 0.21960520635662054 0.9144829864060836 0.08800332732543181 0.20457172875145968 1.5818769341075633e-07 6.800827306500134 0.8143855622786663 EDVFVHQTAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDVFVHQTAIK 11 0 P67809;H0Y449;Q9Y2T7;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX2;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 2;Y-box-binding protein 3 0 41600500.0 5869500.0 16404000.0 19327000.0 False True 8039612.767273373 15679217.03922613 14762360.65205947 1.0 1.9502453032378724 1.8362029465090903 22.938694584137803 -10.120135567631406 5.093101634135281 0.9999730402063405 1.8932241247526822 0.9879219895396116 0.04655759720377427 1.5592246193026678e-05 2.69364816105469e-06 0.04508068269655479 0.015026399879844393 7.5834081743681e-11 10.120135567631406 0.8932510845463417 EDVFVHQTAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDVFVHQTAIK 11 0 P67809;H0Y449;Q9Y2T7;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX2;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 2;Y-box-binding protein 3 0 13843700.0 9052600.0 3287600.0 1503500.0 False True 7527637.998177768 3269889.046262496 1817874.8986014405 1.0 0.4343844705409646 0.2414934005914601 22.84376582029297 -13.999999999996092 0.1501643626866204 3.7356807607620177 0.029675442149077032 0.9995656921022287 0.006707992820337612 11.958331226472943 0.12205020766569748 9.545084488463065 0.19095077844422287 1.0000000000089985e-14 13.999999999996092 -3.7060053186129407 EDVFVHQTAIK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDVFVHQTAIKK 12 1 P67809;H0Y449;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 1 46242600.0 8962600.0 12187000.0 25093000.0 True False 11750055.393941876 10368747.104553936 22496617.069052514 1.0 0.8824424019226226 1.9145966818719322 23.486164222395587 -6.878579851738244 1.0877485354023229 0.9284312829338551 1.985764519102003 0.9725191038479202 0.0764807602541263 0.12889270720208043 0.27998412102899994 0.054231775164266326 0.13067970027476855 1.3225745099321946e-07 6.878579851738244 1.057333236168148 EDVFVHQTAIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDVFVHQTAIKK 12 1 P67809;H0Y449;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 1 778033000.0 12776000.0 216791000.0 548466000.0 True False 12370432.87322883 303356776.85013014 404806300.972691 1.0 24.52272931423704 32.7236973128679 23.560392649015224 -8.740132699404121 0.5482967830551865 8.769506512380889e-20 32.64209418251656 0.9945634284091002 0.9913585549303513 0.33956144287529355 0.21538943160645696 3.0046873669433856 1.588985392308336 1.8191449309107807e-09 8.740132699404121 32.64209418251656 EDVFVHQTAIK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDVFVHQTAIKK 12 1 P67809;H0Y449;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 1 988972000.0 247551000.0 356988000.0 384433000.0 True False 375552965.4022841 293280702.2400255 308449649.0470305 1.0 0.7809303327584424 0.8213212980934022 28.484441148954517 -10.34221092258316 5.728434311703887 1.0000339216439225 0.8011258154259246 0.9699917279087067 0.01648954254818561 7.1449079717576136e-06 8.204452244555057e-07 0.01596865096814661 0.005321976972974662 4.547671410256997e-11 10.34221092258316 -0.19890810621799782 EDVFVHQTAIK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDVFVHQTAIKK 12 1 P67809;H0Y449;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 1 338886600.0 8962600.0 11087000.0 318837000.0 True False 12276315.425157905 10597139.680193849 243534267.25413558 1.0 0.8632182632320676 19.837732969540664 23.54937428391848 -6.905275879234871 0.9273122190437092 0.3211873057032071 22.057331485078418 0.989013222823293 0.9342001312894536 0.10762529477771222 0.1563283715563513 0.7474087631674887 2.001505505254883 1.243724303059761e-07 6.905275879234871 21.73614417937521 up EDVFVHQTAIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDVFVHQTAIKK 12 1 P67809;H0Y449;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 1 651706000.0 12776000.0 291787000.0 347143000.0 True False 10623810.072765749 290215085.5158153 419728996.292119 1.0 27.317420353718937 39.508330195783415 23.3407979244495 -8.51237569276932 0.4991091673514996 2.0711000107382224e-19 40.368611850292595 0.9937168523754338 1.2737855385090926 0.22615315203275566 0.17907344650101892 3.1964168531235395 2.61453866184922 3.073436943018096e-09 8.51237569276932 40.368611850292595 EDVFVHQTAIK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDVFVHQTAIKK 12 1 P67809;H0Y449;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 1 317385000.0 247551000.0 39061000.0 30773000.0 True False 320459649.4597333 36887221.012621425 25172629.7576442 1.0 0.11510722512119709 0.07855163606426903 28.255567471046966 EDVFVHQTAIK(ub)K(ub)NNPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDVFVHQTAIKKNNPR 16 2 P67809;H0Y449;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 2 51802800.0 4332100.0 13056700.0 34414000.0 True False 5679425.052116077 11108691.254617985 30853169.402398005 1.0 1.9559534904821108 5.432445911211123 22.43731345742653 -6.947064379817673 0.5901934162503353 0.959840132129577 6.603549695185442 0.9989503111831435 0.06170592015176493 0.08468640291140973 0.041009186735688985 0.06396002757851718 0.2912603765767036 1.1296284461299193e-07 6.947064379817673 5.6437095630558645 EDVFVHQTAIK(ub)K(ub)NNPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDVFVHQTAIKKNNPR 16 2 P67809;H0Y449;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 2 101041700.0 7679500.0 19547200.0 73815000.0 True False 7435718.476045782 27352498.897301372 54480637.097466715 1.0 3.678528038066212 7.326882704472535 22.826040718696518 -6.9668107906261305 0.3254845779570714 0.5314495371734356 10.592593800302161 0.9999457492678779 0.01909901934969347 0.07735179415342175 0.01272169786192281 0.05412586872642849 0.3194027101451495 1.0794168900977486e-07 6.9668107906261305 10.061144263128726 EDVFVHQTAIK(ub)K(ub)NNPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDVFVHQTAIKKNNPR 16 2 P67809;H0Y449;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 2 150278000.0 31345000.0 49626000.0 69307000.0 True False 47552656.62645111 40769852.57029222 55608441.071662724 1.0 0.857362247719595 1.1694076633508335 25.503022606658966 -6.78246089671992 1.5266543255404945 0.9194917230865735 1.17205624520196 0.7758703517324097 0.060384280075908854 0.2467758003082764 1.1362338256214932 0.031150525835234668 0.07334096029932935 1.6502095772405576e-07 6.78246089671992 0.2525645221153866 EDVFVHQTAIK(ub)K(ub)NNPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDVFVHQTAIKKNNPR 16 2 P67809;H0Y449;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 2 38096300.0 4332100.0 16601200.0 17163000.0 True False 5933794.440600553 15867704.091172941 13109452.883080479 1.0 2.6741243314062273 2.2092866570136334 22.50052351894942 -10.541393098718771 5.738205560811263 0.9966325908909549 2.4417054942099305 0.9276721871840187 0.18976918591397574 0.008178025084556423 0.0006536010430267436 0.18380626572107003 0.06124774138901367 2.8747951353313733e-11 10.541393098718771 1.4450729033189758 EDVFVHQTAIK(ub)K(ub)NNPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDVFVHQTAIKKNNPR 16 2 P67809;H0Y449;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 2 99151500.0 7679500.0 36723000.0 54749000.0 True False 6385844.509533865 36525165.910055205 66196762.76922545 1.0 5.719707997199787 10.366172034160206 22.606445994130794 -7.440984634412535 0.3050340841526395 3.905654820863584e-18 14.026584641814189 0.9996659912770834 0.06988272550742475 0.13393012160640774 0.03223749987575973 0.28264386356055815 0.8809823392620924 3.622558150081458e-08 7.440984634412535 14.026584641814189 EDVFVHQTAIK(ub)K(ub)NNPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDVFVHQTAIKKNNPR 16 2 P67809;H0Y449;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 2 172875000.0 31345000.0 74330000.0 67200000.0 True False 40576720.40232252 70193470.15867881 54970289.530227534 1.0 1.7298951088876344 1.3547248024283687 25.274148928751416 -10.08806330026999 4.47753801220391 0.9999568994149945 1.542309955272392 0.7358671388597156 0.15316263634688496 23465469.833068598 26434302.95334597 8346.478406410271 0.052431646019687785 8.164633596743491e-11 10.08806330026999 0.5423530558573975 EDVFVHQTAIKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 EDVFVHQTAIKK 12 1 P67809;H0Y449;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 1 443930000.0 95690000.0 125990000.0 222250000.0 True False 125450516.66327816 107192783.1051735 199253701.9725388 1.0 0.8544626674825879 1.588305152280527 26.902543171543986 -6.85516698405031 1.2097936469939823 0.9218377613652451 1.620716863323476 0.9475010651065949 0.0726895988852686 0.15186788329999407 0.42512694034235465 0.04694375208176529 0.10905969921237549 1.3958315676276857e-07 6.85516698405031 0.698879101958231 EDVQMK(ub)LEECSQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDVQMKLEECSQR 13 1 A0A0A0MR07;P15498;F5H5P4;Q96D37;P15498-2 A0A0A0MR07 VAV1 Proto-oncogene vav 1 25746500.0 1644400.0 3293300.0 20808800.0 True False 2128708.2159699877 3110024.9599566334 17021811.916318443 1.0 1.4609916646276904 7.9963105270217225 21.02154678110491 -6.9211294692505465 0.816305203044721 0.8615885736392697 9.078067073525753 0.9944889567078596 0.23718406567794967 0.09751184062874646 0.10220375608396183 0.20558988686184948 0.6226496651488108 1.1991417689501485e-07 6.9211294692505465 8.216478499886485 up EDVRPEEIADQELAEALQK(ub)SAEDAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDVRPEEIADQELAEALQKSAEDAER 26 2 Q5TDH0 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 126996600.0 73191300.0 19525700.0 34279600.0 True False 70867882.244392 27322413.835180346 25300744.39404352 1.0 0.38554014837013784 0.3570128469028105 26.07862860161904 EDVRPEEIADQELAEALQK(ub)SAEDAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDVRPEEIADQELAEALQKSAEDAER 26 2 Q5TDH0 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 155701000.0 84585000.0 46931000.0 24185000.0 True False 128321628.99181268 38555796.37642332 19404824.14933792 1.0 0.30046217990954044 0.15122021362880306 26.935189120557773 -13.99999999999993 0.21712061553099682 5.168811228027006 0.06915400310979858 0.9994951768928867 0.008313100450587205 12.922883589571716 0.14763644994663913 23.063712502465673 0.08419135445536495 1.0000000000001595e-14 13.99999999999993 -5.099657224917207 EDVRPEEIADQELAEALQK(ub)SAEDAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDVRPEEIADQELAEALQKSAEDAER 26 2 Q5TDH0 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 138896800.0 73191300.0 44380500.0 21325000.0 True False 60861808.874359645 44141413.43766051 25783958.90434039 1.0 0.7252727819638756 0.4236475941352257 25.859033877053317 -6.969925105778369 0.2599670411788534 1.0847155893348908 0.05525638573700591 0.9999817927488023 0.0010043500262265494 0.0763269974175818 0.009116980611500842 0.00629784046515951 0.028460215950277732 1.0717041050167688e-07 6.969925105778369 -1.029459203597885 down EDVRPEEIADQELAEALQK(ub)SAEDAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDVRPEEIADQELAEALQKSAEDAER 26 2 Q5TDH0 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 186529000.0 84585000.0 57880000.0 44064000.0 True False 109496949.91961882 54658927.11939088 36044804.13482065 1.0 0.49918218872320863 0.329185462803128 26.706315442650222 -13.999999999999998 0.15084760781619555 3.424877800429574 0.1439657433747392 0.9995634350826461 0.0059494656357336135 11.960990341399754 0.12236204850468442 8.499415381669264 0.1670846866932425 1.0000000000000041e-14 13.999999999999998 -3.280912057054835 EDYKFHHTFSTEIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EDYKFHHTFSTEIAK 15 1 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 23762000.0 5744500.0 9948400.0 8069100.0 False True 7436368.49102383 9394762.794653557 6600606.595957715 1.0 1.263353585287447 0.887611554473809 22.82616683057147 -6.718320781922679 1.7655235482752594 1.1605089979881793 0.8882583036195109 0.504514629802427 0.11084355893819024 0.3585859266603673 2.1835419953441764 0.049869600672744444 0.12543144091165215 1.912842524673723e-07 6.718320781922679 -0.27225069436866844 EDYSYIMETK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDYSYIMETKER 12 1 Q96SB8;Q96SB8-2;C9JMN1;A0A0A0MRY1 Q96SB8 SMC6 Structural maintenance of chromosomes protein 6 1 7975890.0 1839100.0 1952290.0 4184500.0 True False 1780718.7771724456 2731849.5780578516 3088453.9176908433 1.0 1.5341274619430254 1.7343861126656477 20.76402826385809 -11.208929843975366 0.1835810062132248 4.960923426974035e-16 1.9172643858184502 0.9994556307943384 0.007232072829989105 3.5257788243233725 0.10697807994082345 1.5938018030230683 0.14175390372146313 6.18116242705577e-12 11.208929843975366 1.9172643858184497 EDYSYIMETK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EDYSYIMETKER 12 1 Q96SB8;Q96SB8-2;C9JMN1;A0A0A0MRY1 Q96SB8 SMC6 Structural maintenance of chromosomes protein 6 1 3565000.0 931300.0 1283200.0 1350500.0 True False 1275626.7774361854 1226503.9810250523 1031539.7144205673 1.0 0.961491247063767 0.808653230448646 20.28277485680977 -6.945054090525924 0.6107380567517283 1.0016888088544027 0.7604862805094902 0.9987537216774613 0.002917208389093789 0.0855347374299536 0.044665482075816505 0.0029632066807150585 0.012891043435895453 1.1348694611042586e-07 6.945054090525924 -0.24120252834491251 EDYSYIMETK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDYSYIMETKER 12 1 Q96SB8;Q96SB8-2;C9JMN1;A0A0A0MRY1 Q96SB8 SMC6 Structural maintenance of chromosomes protein 6 1 7344930.0 1839100.0 2534900.0 2970930.0 True False 1529293.135944232 2521243.9905617475 3592137.726971718 1.0 1.6486335623320867 2.348887628239973 20.544433539292367 -6.97014796649719 0.25462826919930415 0.7900499634144078 3.2281025251981816 0.9999835135519626 0.0022364965226325958 0.07625473512538482 0.008858243452760492 0.015141095426473529 0.06661696198105625 1.0711542949538182e-07 6.97014796649719 2.438052561783774 EDYYDIQLSIK(ub)GK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EDYYDIQLSIKGK 13 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 39874400.0 16019700.0 18678100.0 5176600.0 True False 15511163.392240446 26136362.735004716 3820693.1653288086 1.0 1.685003379442163 0.24631892970969113 23.88680356188603 -6.777197054001424 1.546572534801182 1.389261440091363 0.23585278994041825 0.7574719303686036 0.2893582101784752 0.25492408431411545 1.2041302463437082 0.14738615362551863 0.3486247857277489 1.670332556331196e-07 6.777197054001424 -1.1534086501509448 EDYYDIQLSIK(ub)GK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EDYYDIQLSIKGK 13 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 65073500.0 14393000.0 10045000.0 40635500.0 True False 21835233.26924583 8252391.268056773 32603875.61382762 1.0 0.3779392308888213 1.4931773437817608 24.380154607951024 -6.755322185060943 1.6300356063129877 0.636577796075711 1.496341525660936 0.6715933759586665 0.26149445675581867 0.29085152904557804 1.5219462802916741 0.12664250807861835 0.3057693844353245 1.7566199669713828e-07 6.755322185060943 0.8597637295852251 EDYYDIQLSIK(ub)GK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EDYYDIQLSIKGK 13 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 36781500.0 16019700.0 18166200.0 2595600.0 True False 13321090.343040505 18068335.074891638 3138327.959301561 1.0 1.3563705830079662 0.2355909222506816 23.667208837320306 -6.821174626634278 1.3668176683298472 1.1918449971459129 0.2105030556589217 0.8870861066065124 0.1571108961468901 0.1919369667423343 0.7042632007887474 0.09032293495356677 0.2081140085209244 1.5094730840379118e-07 6.821174626634278 -0.9813419414869912 down EEAAAVPAAAPDDLALLK(ub)NLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEAAAVPAAAPDDLALLKNLR 21 1 E5RJU9;Q86UE4 E5RJU9 MTDH Protein LYRIC 1 32321600.0 22098000.0 5727100.0 4496500.0 True False 21396511.08583362 8013960.89643196 3318731.757891474 1.0 0.3745452174087349 0.1551062107545546 24.350872234224884 -10.975132819301221 0.2083029497342953 1.9874972850409067 1.9133721544117221e-22 0.9993371472683138 0.009215907846085409 3.0330110601836546 0.11508650463182422 1.5682414119946675 0.12762643612310037 1.0589298255324703e-11 10.975132819301221 -1.9874972850409067 EEAAAVPAAAPDDLALLK(ub)NLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEAAAVPAAAPDDLALLKNLR 21 1 E5RJU9;Q86UE4 E5RJU9 MTDH Protein LYRIC 1 11143900.0 5226200.0 2756100.0 3161600.0 True False 7158467.372744541 2634326.3887960953 2414895.1951959035 1.0 0.36800145221393954 0.33734807598487915 22.771219308989163 -13.60366368351368 0.4350317253208539 9.999986186586112 0.33688383732298416 0.9998764986257966 0.003394035951720233 22.725285911107548 0.22174634116783212 193.0360346549781 0.007168626878885437 2.4907854292048793e-14 13.60366368351368 -9.663102349263127 EEAAAVPAAAPDDLALLK(ub)NLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEAAAVPAAAPDDLALLKNLR 21 1 E5RJU9;Q86UE4 E5RJU9 MTDH Protein LYRIC 1 32656200.0 22098000.0 7930400.0 2627800.0 True False 18375466.107387073 7887677.361138841 3177260.83042559 1.0 0.4292504644531404 0.17290776799116445 24.13127750965916 -9.538761496843835 0.23533451293185587 1.4522965046414702 9.331670209219984e-17 0.9992038809404473 0.009753996892015882 0.950884461460606 0.09506834065432106 0.43062411124119415 0.11903097747080774 2.89226780403839e-10 9.538761496843835 -1.4522965046414702 EEAATGGGSTGEADGK(ub)TAAAAAEHSQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEAATGGGSTGEADGKTAAAAAEHSQR 27 1 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 51382600.0 25959900.0 18385600.0 7037100.0 True False 34033680.296029225 15642540.146507496 6308968.396629719 1.0 0.4596194126067683 0.18537426284061906 25.020459832491866 -9.073794466009653 0.24644699047482957 1.3343962309834863 5.361849274206566e-23 0.9991832447613751 0.009672072931444054 0.5226213160760883 0.08523328538952987 0.26288586531809954 0.11506057245220878 8.437339684096511e-10 9.073794466009653 -1.3343962309834863 EEAATGGGSTGEADGK(ub)TAAAAAEHSQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEAATGGGSTGEADGKTAAAAAEHSQR 27 1 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 69948400.0 34615200.0 25016200.0 10317000.0 True False 33516359.42340248 35005299.11775958 7614668.196634354 1.0 1.044424266834824 0.22719258080629975 24.998362114947952 -6.894054015505542 0.9981238801717806 1.0397392998254806 0.15106492789521858 0.9833677274421653 0.0483899600071356 0.11591428135325037 0.20314181841210213 0.036730138020391205 0.09300849700349084 1.2762800612266515e-07 6.894054015505542 -0.8886743719302621 down EEAATGGGSTGEADGK(ub)TAAAAAEHSQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEAATGGGSTGEADGKTAAAAAEHSQR 27 1 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 86553000.0 64616000.0 12611000.0 9326000.0 True False 98027196.06236304 10360468.519807266 7482712.012268988 1.0 0.10568973648104892 0.07633302096602487 26.546678721410345 -12.97973323173872 0.4997806154253529 9.999999996891628 0.07780492751147884 0.9999278887675948 0.0036401803836110485 16.574059175797426 0.2494869000840758 161.50624360500092 0.005982261786020353 1.0477719512824356e-13 12.97973323173872 -9.922195069380148 EEAATGGGSTGEADGK(ub)TAAAAAEHSQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEAATGGGSTGEADGKTAAAAAEHSQR 27 1 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 54135900.0 25959900.0 21729500.0 6446500.0 True False 35557976.56991906 20769418.840152618 4923969.469835014 1.0 0.5841001329002197 0.13847721228323603 25.083669894014758 -7.685239496739212 0.4301260382891818 1.0350420311607975 1.5262617516004222e-15 0.997729082696533 0.016764010229484726 0.11819326301572923 0.07054531556113323 0.027430276673479723 0.07514835059554333 2.064241491914307e-08 7.685239496739212 -1.035042031160796 down EEAATGGGSTGEADGK(ub)TAAAAAEHSQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEAATGGGSTGEADGKTAAAAAEHSQR 27 1 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 76288200.0 34615200.0 36667400.0 5005600.0 True False 28784072.513368856 36469865.43829094 6052247.816720577 1.0 1.267015479527867 0.21026377743835903 24.778767390382228 -6.839733001591321 1.2835791822580414 1.1420526260533492 0.17567712998524854 0.924005885535859 0.12368368982217369 0.1691079534479694 0.5413255046772409 0.07555997777186686 0.17406861943950214 1.4463286809010328e-07 6.839733001591321 -0.9663754960681007 down EEAATGGGSTGEADGK(ub)TAAAAAEHSQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEAATGGGSTGEADGKTAAAAAEHSQR 27 1 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 104206700.0 64616000.0 24332900.0 15257800.0 True False 83646685.77178103 22978752.724661816 12481036.958248604 1.0 0.27471205239806296 0.14921137452237462 26.317805043502794 -13.999999999999998 0.24678708252884948 5.963501039458132 0.09718453288500083 0.9995367547739572 0.008071202259610537 13.872896487374888 0.15720407925741786 34.07010741293047 0.05897095662400285 1.0000000000000041e-14 13.999999999999998 -5.866316506573131 EEAIK(ub)FSEEQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEAIKFSEEQR 11 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 5405300.0 1288500.0 2241900.0 1874900.0 True False 1071444.8402284486 2229822.439717689 2266932.921441866 1.0 2.0811360099902636 2.115771933680245 20.031126148897886 -10.9238659135636 0.6026395490109013 1.895587771241832e-21 2.111545256456285 0.9999100233718702 0.0049136251878116235 2.7154333578556997 0.2975141503714926 3.825011029508671 0.006001486147011747 1.1916098553356013e-11 10.9238659135636 2.111545256456285 EEAK(ub)SHPFSVIYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEAKSHPFSVIYR 13 1 Q8N2K0-2;Q8N2K0;Q8N2K0-3;A0A5F9ZHQ8;A0A5F9ZGT4;A0A5F9ZH71;A0A5F9ZH49;A0A5F9ZHH2;A0A5F9ZHQ0;I3L206;A0A5F9ZGZ9;A0A5F9ZHF0;A0A5F9ZGW7;A0A5F9ZHM3;A0A5F9ZH28;I3L294;I3L1V0 Q8N2K0-2 ABHD12 Monoacylglycerol lipase ABHD12 1 55434400.0 1651400.0 22579000.0 31204000.0 True False 2505294.533511613 18549601.03946782 25036515.722800974 1.0 7.404159786940211 9.993442043601904 21.256548792328587 -8.813064533895576 0.42237748894111626 2.2443127769782373e-13 10.391130078913712 0.9969272315180028 0.2095383644453352 0.35069628658654006 0.14895901026495936 1.2921197343459043 0.6135418527238338 1.5379260955242104e-09 8.813064533895576 10.391130078913488 EEAK(ub)SHPFSVIYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEAKSHPFSVIYR 13 1 Q8N2K0-2;Q8N2K0;Q8N2K0-3;A0A5F9ZHQ8;A0A5F9ZGT4;A0A5F9ZH71;A0A5F9ZH49;A0A5F9ZHH2;A0A5F9ZHQ0;I3L206;A0A5F9ZGZ9;A0A5F9ZHF0;A0A5F9ZGW7;A0A5F9ZHM3;A0A5F9ZH28;I3L294;I3L1V0 Q8N2K0-2 ABHD12 Monoacylglycerol lipase ABHD12 1 13591300.0 1335800.0 2986100.0 9269400.0 True False 1110776.8859737394 2970013.286605558 11207588.683136817 1.0 2.673816248887784 10.089864872648945 20.083137631033605 -6.942533576065614 0.6355561187059118 0.91900947885747 12.248180257279927 0.9984772782957029 0.1541385808718292 0.086629576524326 0.04948717312778345 0.15309694118270717 0.6315047754505292 1.1414750517756603e-07 6.942533576065614 11.329170778422457 EEAK(ub)SHPFSVIYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEAKSHPFSVIYR 13 1 Q8N2K0-2;Q8N2K0;Q8N2K0-3;A0A5F9ZHQ8;A0A5F9ZGT4;A0A5F9ZH71;A0A5F9ZH49;A0A5F9ZHH2;A0A5F9ZHQ0;I3L206;A0A5F9ZGZ9;A0A5F9ZHF0;A0A5F9ZGW7;A0A5F9ZHM3;A0A5F9ZH28;I3L294;I3L1V0 Q8N2K0-2 ABHD12 Monoacylglycerol lipase ABHD12 1 45099400.0 1651400.0 18174000.0 25274000.0 True False 2137769.853960617 17162600.923770063 20674391.333139434 1.0 8.028273432695828 9.671008923077604 21.027675114421037 -9.221990206168552 0.511591131714696 5.340245501554538e-15 9.660197713800443 0.9976115085031175 0.1837906497341548 0.6144530049254902 0.21093474357888034 1.7258828680931027 0.3245800841162194 5.998046023747336e-10 9.221990206168552 9.660197713800438 EEAQK(ub)LLEQYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEAQKLLEQYK 11 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 11387800.0 3752600.0 3927800.0 3707400.0 True False 4919694.940230099 3341787.5504444847 3323793.8118919753 1.0 0.6792672291766502 0.6756097384640923 22.230137429225678 EEAQK(ub)LLEQYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEAQKLLEQYK 11 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 9778900.0 3433100.0 2438700.0 3907100.0 True False 3324118.1196839274 3412485.6276524975 2883713.2995124627 1.0 1.026583744857109 0.8675122831635897 21.664540217273135 -6.86394761737579 1.1657069653962584 1.014602942573376 0.8592107171159737 0.9582562405334518 0.01421462728867492 0.14278592915370875 0.3664866782946683 0.009494698378035021 0.022270295836707567 1.3678938047724496e-07 6.86394761737579 -0.15539222545740228 EEAQK(ub)LLEQYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEAQKLLEQYK 11 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 8937300.0 3752600.0 2392300.0 2792400.0 True False 5140037.6302019 2286600.275721816 2132892.631283224 1.0 0.44486061002475547 0.4149566179731342 22.29334749074857 -13.84201816188358 0.4173895483636542 9.999027721694663 0.4138681138784682 0.9998587143134432 0.003197674443943413 25.673207184105085 0.214876299366701 209.52969442627432 0.007307534092714557 1.4387384099899023e-14 13.84201816188358 -9.585159607816195 EEAQK(ub)LLEQYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEAQKLLEQYK 11 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 8207800.0 3433100.0 2196900.0 2577800.0 True False 2854774.7621174124 2185064.8636494917 3116806.0615994693 1.0 0.7654070971360308 1.091787030962718 21.44494549270741 -6.713792456356233 1.7814928137494945 0.856340871576345 1.0911156369886397 0.48316817466761874 0.0987996803962953 0.3675104978010607 2.275861141623796 0.04409369202750719 0.11151467288576691 1.9328918000100286e-07 6.713792456356233 0.2347747654122947 EEAQK(ub)LLEQYKEESKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEAQKLLEQYKEESKK 16 3 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 12928000.0 2264600.0 6370000.0 4293400.0 True False 2968912.5304175983 5419620.83006552 3849160.153200892 1.0 1.8254565516967964 1.2964882305439562 21.501503158845555 -10.117521278787706 4.252462607369087 0.9999096076631463 1.5609723904629154 0.5999287776789355 0.2159504131057749 27807252.919102352 16539874.139501628 23660.650672162606 0.07392556949999943 7.629195100740986e-11 10.117521278787706 0.5610627827997691 EEAQK(ub)LLEQYKEESKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEAQKLLEQYKEESKK 16 3 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 11747800.0 2264600.0 4621600.0 4861600.0 True False 3101883.8185138893 4417402.430412545 3713390.2077949094 1.0 1.4241031221243223 1.1971403266721938 21.564713220368446 -10.10308211887129 4.3122204701766345 0.9999598304278345 1.310621724341306 0.7140756315830521 0.09265717335730399 13598059.102512207 15929418.4676553 4301.684653159076 0.03171901555590151 7.887109695611055e-11 10.10308211887129 0.31066189391347154 EEASDYLELDTIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEASDYLELDTIK 13 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 82376000.0 12393000.0 33793000.0 36190000.0 False True 16247343.013982728 28751216.124082323 32445405.958992958 1.0 1.7695949484994906 1.9969668844358066 23.953700472570237 -10.807922813025616 0.2438094531636862 3.117969323502723e-11 2.11674800940626 0.9992178791963702 0.011930581315906524 2.6439605063723843 0.12698778669059313 1.6374253609056533 0.1073415362964211 1.556242197294191e-11 10.807922813025616 2.1167480093750806 EEASDYLELDTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEASDYLELDTIK 13 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 111016000.0 39088000.0 11970000.0 59958000.0 False True 37847172.83568946 16749683.422725353 44253201.09855601 1.0 0.44256102022316945 1.169260417169806 25.173682199871248 -6.701736885900614 1.8244640488197643 0.6544507989422259 1.1671868026494923 0.4259393347307171 0.2352270190848392 0.39191109322802536 2.5373568901542005 0.10280576648453009 0.26384467495815733 1.9872985428388972e-07 6.701736885900614 0.5127360037072664 EEASDYLELDTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEASDYLELDTIK 13 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 83856000.0 12393000.0 34858000.0 36605000.0 False True 16975027.00823219 33317858.300008815 27959652.90363927 1.0 1.9627573071813684 1.6471050614576335 24.016910534093128 -10.246223636041275 5.9873028213778765 0.9999753020174099 1.8049311843195026 0.8965915204777514 0.1288644896978057 4.24863640065688e-05 5.348637738214599e-06 0.12477631926386695 0.04159083520975818 5.6725242864679425e-11 10.246223636041275 0.8049558823020927 EEASDYLELDTIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEASDYLELDTIK 13 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 62814000.0 39088000.0 11144000.0 12582000.0 False True 32503403.89200592 11083965.060089193 15212838.027404942 1.0 0.34100936310905117 0.46803830386350637 24.954087475305524 -9.996738424834742 6.1002956935774115 1.0000004515149168 0.4045238334894085 0.9669962973527513 0.05185934790260203 3.183996775146584e-07 5.237336145148117e-08 0.05021263585038455 0.016737532564306 1.007538325541813e-10 9.996738424834742 -0.5954766180255082 EEASGSSVTAEEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEASGSSVTAEEAK 14 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 7720690.0 1744100.0 970790.0 5005800.0 False True 1688734.5001720723 1358431.5096029725 3694630.809218975 1.0 0.8044079809256909 2.187810344872159 20.687511097348853 -6.8710813333253276 1.12830502882041 0.8886127687593717 2.2705310310521325 0.9657532884533255 0.11312237148372022 0.1358250865745059 0.32250905079519815 0.07775385808699353 0.1844466113072207 1.3456083290976565e-07 6.8710813333253276 1.3819182622927608 up EEDAFHFVSYVPVNGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEDAFHFVSYVPVNGR 16 0 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 17246100.0 2656000.0 7647100.0 6943000.0 False True 3482041.720740589 6506182.488162333 6224604.9619587725 1.0 1.868496419617438 1.7876307813551622 21.731502058339885 -10.033113710288298 4.505391081355858 0.9999637330659696 1.8280636004866608 0.9928982289510148 0.033013258811941455 5706974.4055703655 0.17525482856908248 2158.827326507633 0.011649130466713523 9.26587185503445e-11 10.033113710288298 0.8280998674206912 EEDAFHFVSYVPVNGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEDAFHFVSYVPVNGR 16 0 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 12038500.0 2656000.0 3754000.0 5628500.0 False True 3637994.975701178 3588135.86718208 4299164.222596201 1.0 0.9862948935190632 1.181740010998116 21.794712119862776 -6.890073454643979 1.0219175837663792 0.9895170217116142 1.198576234907082 0.9809463300778112 0.012296059233765852 0.11908478764954336 0.22148477657243862 0.009166899410025166 0.02285994760539954 1.2880316812985141e-07 6.890073454643979 0.20905921319546794 EEDKEPLIELFVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEDKEPLIELFVK 13 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 0 3135100.0 1276900.0 1858200.0 0.0 False True 1674028.2655171887 1580963.8032068708 0.0 1.0 0.9444068751840544 0.0 20.67489245693597 -7.070855002609332 1.0245883619596092 1.0068177133303122 9.629142925396672e-21 0.9887572989148719 0.048653949694194794 0.08443149947449824 0.16970134380438545 0.03944106926887064 0.07017526215428187 8.494640372618666e-08 7.070855002609332 -1.0068177133303122 down EEDKEPLIELFVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEDKEPLIELFVK 13 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 0 7143100.0 2396000.0 1931700.0 2815400.0 False True 2319940.2915040944 2703037.8836824247 2077962.2798104428 1.0 1.1651325224107192 0.8956964484905906 21.14565624439278 -6.740852220778818 1.683488986301028 1.0981554492861387 0.895506181130608 0.6088007337737337 0.06938050062390147 0.31627606180657836 1.7603351231898132 0.03259814801080227 0.07992091578271172 1.816133541088586e-07 6.740852220778818 -0.20264926815553075 EEDKEPLIELFVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEDKEPLIELFVK 13 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 0 4419900.0 1276900.0 0.0 3143000.0 False True 1749004.436925011 0.0 2400688.132116879 1.0 0.0 1.3726026540776632 20.738102518458863 -6.711363223148391 1.7904804926634983 0.38607903389584136 1.3694929450992523 0.4715345566970398 0.42130521381252384 0.3723304816704837 2.327630741277421 0.18719877948519809 0.4747643547659851 1.9437337556106269e-07 6.711363223148391 0.983413911203411 EEDKEPLIELFVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEDKEPLIELFVK 13 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 0 5111600.0 2396000.0 1272800.0 1442800.0 False True 1992380.160797336 1265943.1737689807 1744482.8092465324 1.0 0.635392380770525 0.8755772836788352 20.926061519827055 -10.170630218780056 5.083687129489957 1.000014861044071 0.7554848322244152 0.5801571751356749 0.09805507600846801 1.6516755625898074e-05 2.6947275631197492e-06 0.09494718573133534 0.03164713969919274 6.751026010012895e-11 10.170630218780056 -0.2445300288196557 EEEAIQLDGLNASQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEEAIQLDGLNASQIR 16 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 86287420.0 6280600.0 36756820.0 43250000.0 False True 8233927.421416915 31272845.732962143 38774904.883295 1.0 3.7980472904849374 4.70916282094487 22.97314930129361 -9.364014862406128 0.3575953320481823 3.934277788455338e-23 4.924054055012339 0.9982914753576544 0.06523474588469601 0.738250401217386 0.14118146913002563 1.223214275483787 0.2593481123056698 4.3249902981949903e-10 9.364014862406128 4.924054055012339 EEEAIQLDGLNASQIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEEAIQLDGLNASQIR 16 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 71436100.0 24716000.0 6735100.0 39985000.0 False True 23931404.10885438 9424460.553082509 29511728.975712314 1.0 0.39381143330388846 1.2331800023715813 24.512401709706992 -6.712960376377657 1.7848512390020659 0.6284603338835857 1.2313693244626 0.4790938414501569 0.25532914729713846 0.3691385952230735 2.2941587267242056 0.11376871495831338 0.2879717132818873 1.9365986448765054e-07 6.712960376377657 0.6029089905790144 EEEAIQLDGLNASQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEEAIQLDGLNASQIR 16 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 72379600.0 6280600.0 37074000.0 29025000.0 False True 8602707.546833131 35435948.09267676 22169892.788639 1.0 4.119162240464818 2.5770831645672163 23.0363593628165 -9.898035456589469 10.771759300517196 1.0000000010182373 3.348122702208338 0.7555899116767154 0.6295511464952896 0.0 0.0 0.6095602764905106 0.20318675883017015 1.2646330963159214e-10 9.898035456589469 2.3481227011901007 EEEAIQLDGLNASQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEEAIQLDGLNASQIR 16 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 33380700.0 24716000.0 3762600.0 4902100.0 False True 20552449.104451947 3742330.1269823713 5927106.445250497 1.0 0.18208682128164133 0.28838930168991894 24.29280698514127 -10.708076075365742 6.88823374674729 1.0074590921755988 0.23523806203406855 0.9857160810077629 0.043397805898747636 0.0049503274589439905 0.00020979503024868085 0.04184309388212993 0.014006581625649307 1.9585015727298145e-11 10.708076075365742 -0.7722210301415302 EEECHFYAGGQVYPGEASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEECHFYAGGQVYPGEASR 19 0 Q13162;A6NG45 Q13162 PRDX4 Peroxiredoxin-4 0 42293800.0 8926800.0 15437000.0 17930000.0 False True 11703121.247254167 13133859.772954706 16074775.596704734 1.0 1.1222527303163867 1.3735460188004343 23.480390015165575 -6.959505757804174 0.44234505450365363 0.9912313778587203 1.5144031647745775 0.9997514237203431 0.002451700625696145 0.07987815948512497 0.02178731909840834 0.003323053460325791 0.020812208719197374 1.0977267366983212e-07 6.959505757804174 0.5231717869158572 EEECHFYAGGQVYPGEASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEECHFYAGGQVYPGEASR 19 0 Q13162;A6NG45 Q13162 PRDX4 Peroxiredoxin-4 0 32078900.0 8926800.0 15040000.0 8112100.0 False True 12227279.197699266 14375483.069370933 6196189.053943789 1.0 1.1756894430018316 0.5067512529778243 23.543600076688467 -6.836900073700525 1.2966618025004426 1.0935333072466744 0.4860585131643276 0.9190012764670097 0.08058940562836747 0.17244976795870845 0.5645477615610585 0.04875771327428571 0.11225546865781064 1.455794003955866e-07 6.836900073700525 -0.6074747940823468 EEEDGQWK(ub)EEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEEDGQWKEEQK 12 1 P55735;P55735-2;P55735-4;P55735-3;A8MXL6 P55735 SEC13 Protein SEC13 homolog 1 3380110.0 1082500.0 960810.0 1336800.0 True False 1419167.9829449109 817460.8932080462 1198480.7594910676 1.0 0.5760141879129318 0.8444953479038501 20.436613936607046 -10.484655795963537 6.077023189965835 1.0002139230684761 0.710254767908391 0.6082887285231926 0.10960697458804737 0.00031791070687925833 2.6959268398321774e-05 0.10620389708426387 0.03537549893397392 3.276002345565796e-11 10.484655795963537 -0.2899591551600851 EEEDGQWK(ub)EEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEEDGQWKEEQK 12 1 P55735;P55735-2;P55735-4;P55735-3;A8MXL6 P55735 SEC13 Protein SEC13 homolog 1 3660900.0 1082500.0 1076100.0 1502300.0 True False 1482729.5034625453 1028554.3438131696 1147487.6808397025 1.0 0.693689807487635 0.7739022378390872 20.499823998129937 -9.853284940570623 6.106112182765636 1.0000000264998703 0.7337960226632143 0.9362462632601831 0.032746587565456585 1.181973589179283e-08 2.24390832658333e-09 0.031706750378570354 0.010568915690434406 1.401893620482767e-10 9.853284940570623 -0.266204003836656 EEEDGQWK(ub)EEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEEDGQWKEEQK 12 1 P55735;P55735-2;P55735-4;P55735-3;A8MXL6 P55735 SEC13 Protein SEC13 homolog 1 4871490.0 964690.0 1622000.0 2284800.0 True False 802182.4780131797 1613261.964058206 2762541.116278403 1.0 2.011091002702879 3.4437814237984576 19.613570928298568 -6.966186252630122 0.33707373724387163 0.8392410664436093 4.663033317872398 0.9999355506129555 0.008048958949401426 0.07756069451032496 0.013453141018156952 0.020410593415570475 0.12427531477847917 1.0809702642340463e-07 6.966186252630122 3.823792251428789 EEEEAFASSQSSQGAQSLTFSK(ub)FEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEEEAFASSQSSQGAQSLTFSKFEEK 26 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;V9GYI8 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 473230000.0 136720000.0 191560000.0 144950000.0 True False 179241243.9983632 162979994.69503167 129951964.4585806 1.0 0.9092773016935766 0.7250115071716825 27.41732740355646 -6.959742094997292 0.4390546762029425 1.0066538766829662 0.6204619566596603 0.9997605084392052 0.0017705166620480617 0.07979340017388079 0.02147281497126743 0.0024266123236434687 0.015270333370475028 1.0971295311402816e-07 6.959742094997292 -0.38619192002330593 EEEEAFASSQSSQGAQSLTFSK(ub)FEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEEEAFASSQSSQGAQSLTFSKFEEK 26 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;V9GYI8 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 1510985200.0 426484100.0 429690000.0 654811100.0 True False 412945595.6910934 601267457.8037487 483296428.99807626 1.0 1.4560452129232315 1.170363442644898 28.62137648264007 -10.321721129451259 6.312738017855585 0.9999836312189474 1.3132043277840622 0.6157710524829383 0.11662909433281991 2.687069715523662e-05 2.887412453200973e-06 0.11293153185949877 0.037641878336188726 4.7673701242274473e-11 10.321721129451259 0.31322069656511475 EEEEAFASSQSSQGAQSLTFSK(ub)FEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEEEAFASSQSSQGAQSLTFSKFEEK 26 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;V9GYI8 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 1932560900.0 604511100.0 905774000.0 422275800.0 True False 917087534.3811858 744131552.8554358 338812803.0399418 1.0 0.8114073356776638 0.3694443445560071 29.772484202178326 -6.956831798538302 0.47799654783962847 1.0108109717851 0.1516763713284082 0.9996340506911661 0.00505523318494069 0.08085289011256556 0.025464994044081323 0.006206448724803665 0.03646103832235018 1.1045063103568094e-07 6.956831798538302 -0.8591346004566918 down EEEEAFASSQSSQGAQSLTFSK(ub)FEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEEEAFASSQSSQGAQSLTFSKFEEK 26 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;V9GYI8 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 561970000.0 136720000.0 159030000.0 266220000.0 True False 187269078.7190754 152003528.75811574 203344318.97300506 1.0 0.8116851420310454 1.0858403339402567 27.48053746507935 -6.721852304069894 1.7524424381236245 0.8856554504108823 1.0854624415509457 0.5212220989487129 0.07922683215434288 0.35179012675726884 2.112325040812893 0.03588123014617572 0.08988673111775007 1.8973510672972038e-07 6.721852304069894 0.1998069911400634 EEEEAFASSQSSQGAQSLTFSK(ub)FEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEEEAFASSQSSQGAQSLTFSKFEEK 26 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;V9GYI8 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 1415381800.0 426484100.0 601147200.0 387750500.0 True False 354640425.5991259 597908700.715223 468827336.7942519 1.0 1.6859575433486527 1.3219793992808908 28.401781758074346 -10.028853166955466 4.257137169342286 0.9999640717432546 1.5039684710749577 0.7188009785605002 0.14859345555765824 103517182.49044545 174389005.11059368 51878.28997474191 0.05437961522724555 9.357219841395148e-11 10.028853166955466 0.504004399331703 EEEEAFASSQSSQGAQSLTFSK(ub)FEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEEEAFASSQSSQGAQSLTFSKFEEK 26 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;V9GYI8 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 1633906100.0 604511100.0 826925000.0 202470000.0 True False 782551535.6452527 780905896.8245046 165622537.51763627 1.0 0.9978970856923932 0.2116442559672089 29.543610524270775 -6.907485306748324 0.9126910680968493 1.0263221432625624 0.11531633340438438 0.9899374264243384 0.03722991549675344 0.10610449502873603 0.14796209117867445 0.030106598059118146 0.08172854723275688 1.237413053957636e-07 6.907485306748324 -0.911005809858178 down EEEEFNTGPLSVLTQSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEEEFNTGPLSVLTQSVK 18 0 P62316;K7ERG4;P62316-2 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 6050800.0 2250100.0 0.0 3800700.0 False True 2178671.8071424696 0.0 2805182.6514440374 1.0 0.0 1.2875654985058511 21.055017456063144 -6.699401151547841 1.8330833569794704 0.37867742518412323 1.2836851041255688 0.41472454430842176 0.4221582649875773 0.39675594046505436 2.5914895840996373 0.1837610573866084 0.4729208814685641 1.9980154789470897e-07 6.699401151547841 0.9050076789414456 EEEGEETAQVLAASK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEEGEETAQVLAASKER 17 1 Q8NBR6-2;Q8NBR6;H0YM15;J3KNL7 Q8NBR6-2 FAM63B Protein FAM63B 1 35029300.0 13074000.0 11965000.0 9990300.0 True False 17140140.608796105 10179868.639204709 8956599.58972443 1.0 0.5939197858143899 0.522551115194937 24.030875608830023 -13.999999999999998 0.24457701520648728 3.748719087222653 0.4923373203769193 0.9995327975889624 0.004545130048653278 13.78954632766839 0.15650630951220917 18.561997819924 0.033959854551849855 1.0000000000000041e-14 13.999999999999998 -3.2563817668457338 EEEGEETAQVLAASK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEEGEETAQVLAASKER 17 1 Q8NBR6-2;Q8NBR6;H0YM15;J3KNL7 Q8NBR6-2 FAM63B Protein FAM63B 1 33099700.0 10703000.0 7803700.0 14593000.0 True False 10363239.123525998 10919758.105757892 10770655.519384034 1.0 1.053701258419148 1.0393136152704558 23.3049716650224 -10.561577204665095 6.062804591881248 0.9998978000535496 1.046507436844802 0.9330283457782391 0.005873730719257714 8.131913661364682e-06 5.88045032756198e-07 0.005699702797829366 0.0018957384379826585 2.7442444549236737e-11 10.561577204665095 0.04660963679125241 EEEGEETAQVLAASK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEEGEETAQVLAASKER 17 1 Q8NBR6-2;Q8NBR6;H0YM15;J3KNL7 Q8NBR6-2 FAM63B Protein FAM63B 1 108389000.0 26600000.0 61162000.0 20627000.0 True False 40354144.72048499 50247163.239112906 16550064.408864735 1.0 1.2451549546435046 0.41012055944933506 25.2662135226118 -6.8280935589370175 1.3363254356931349 1.1311811765986883 0.38850086618929264 0.9020171289306458 0.10969882955704888 0.1831803084865558 0.6404114583615309 0.06446445510876929 0.14837323120001333 1.4856155654925707e-07 6.8280935589370175 -0.7426803104093957 down EEEGEETAQVLAASK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEEGEETAQVLAASKER 17 1 Q8NBR6-2;Q8NBR6;H0YM15;J3KNL7 Q8NBR6-2 FAM63B Protein FAM63B 1 44457000.0 13074000.0 12727000.0 18656000.0 True False 17907811.111565206 12164679.057439078 14249837.032380667 1.0 0.6792945816578831 0.7957330431734256 24.094085670352914 -10.307379847916986 5.1486454100231684 1.0000712932237668 0.7375138127320511 0.8713953905304651 0.047535802858103854 3.8912064716274504e-05 5.234622530152258e-06 0.046038811269755515 0.015342114401482622 4.9274264686925006e-11 10.307379847916986 -0.2625574804917157 EEEGEETAQVLAASK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEEGEETAQVLAASKER 17 1 Q8NBR6-2;Q8NBR6;H0YM15;J3KNL7 Q8NBR6-2 FAM63B Protein FAM63B 1 34261000.0 10703000.0 12159000.0 11399000.0 True False 8900018.723294599 12093497.053627454 13782478.196978927 1.0 1.3588170350669437 1.548589798008531 23.085376940456676 -11.162295640942718 0.1106316021618769 1.408162806500952e-19 1.9604223513429353 0.99984206955996 0.0028587125687313856 3.6565688282259843 0.0691881660420739 1.1947201827075795 0.27841365480303487 6.881836637891043e-12 11.162295640942718 1.9604223513429353 EEEGEETAQVLAASK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEEGEETAQVLAASKER 17 1 Q8NBR6-2;Q8NBR6;H0YM15;J3KNL7 Q8NBR6-2 FAM63B Protein FAM63B 1 68821000.0 26600000.0 34912000.0 7309000.0 True False 34434224.364389256 32969116.509885564 5978836.996673105 1.0 0.9574519861693513 0.17363065691284227 25.03733984470425 -6.918111855419772 0.8386176143330039 1.0184996153574868 0.05256601087036033 0.9936399660043322 0.03029878063240494 0.09929568349729478 0.111467331058527 0.025847720135638238 0.07608154077090745 1.207502794712215e-07 6.918111855419772 -0.9659336044871265 down EEEGVK(ub)YER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEEGVKYER 9 1 Q8TB45;Q8TB45-2 Q8TB45 DEPTOR DEP domain-containing mTOR-interacting protein 1 2668230.0 665460.0 1150210.0 852560.0 True False 644335.3365543884 1609494.851265912 629248.9597482386 1.0 2.4979149209365987 0.9765861408644373 19.297452191458824 -6.649699582031797 2.009364565805823 1.972211048724748 0.9829469113292684 0.19294665011406487 0.6393699363132445 0.5092533641586734 3.940724740162671 0.2580741916256713 0.7082800484283363 2.2402702826454278e-07 6.649699582031797 -0.9892641373954796 EEEGVK(ub)YER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEEGVKYER 9 1 Q8TB45;Q8TB45-2 Q8TB45 DEPTOR DEP domain-containing mTOR-interacting protein 1 2908560.0 665460.0 1705410.0 537690.0 True False 553359.4748765422 1696222.6178326197 650118.4930023346 1.0 3.065317745234338 1.1748574344866507 19.0778574668931 -6.6251577952088505 2.0984698959154153 2.365445512736779 1.1823562513273251 0.10025090609452636 0.8870038712675793 0.5716627472344261 4.790786191657502 0.3465200825998002 0.9827063555401511 2.3705122546089783e-07 6.6251577952088505 -1.183089261409454 EEEITLYPDK(ub)HGCVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEEITLYPDKHGCVR 15 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 10776000.0 2279000.0 5626100.0 2870900.0 True False 2987791.0698673967 4786707.8103660345 2573846.807617379 1.0 1.6020892018324684 0.8614547494887621 21.510647836258258 -6.690552933492055 1.8650557945663293 1.3772863093877805 0.8640386556043564 0.3727958012851411 0.254613855101667 0.4154509276606654 2.8024155898979926 0.10921061047558475 0.28413059011311625 2.039140106174543e-07 6.690552933492055 -0.5132476537834241 EEEITLYPDK(ub)HGCVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEEITLYPDKHGCVR 15 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 29056900.0 8720000.0 5864000.0 14472900.0 True False 13228877.517392054 4817523.384358884 11612324.971302595 1.0 0.3641672075370921 0.8778012311351305 23.657187317000172 -10.125187912941149 7.415522311651 1.000000123443647 0.6209842193361584 0.420630848876676 0.2096902120579747 4.278821035469464e-07 5.05899362346725e-08 0.20303174134887983 0.06767722493026981 7.495698111400092e-11 10.125187912941149 -0.37901590410748864 EEEITLYPDK(ub)HGCVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEEITLYPDKHGCVR 15 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 9652500.0 2279000.0 3807000.0 3566500.0 True False 3121607.8876592577 3638794.151934518 2724166.1543731606 1.0 1.1656794456215553 0.8726804430315175 21.57385789778115 -6.7533250319480596 1.6378424223892807 1.097031867956624 0.8719580025168876 0.6630365730666252 0.06963363003446235 0.29427854230845285 1.5541795795402882 0.033573653707555426 0.0812155578529166 1.764716588229959e-07 6.7533250319480596 -0.2250738654397364 EEEITLYPDK(ub)HGCVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEEITLYPDKHGCVR 15 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 42876200.0 8720000.0 17264500.0 16891700.0 True False 11288211.896897515 16303715.398284812 13817583.923478324 1.0 1.4443133728527697 1.224071983205417 23.42831363909262 -10.129575387096528 4.361738425787896 0.9999478872789054 1.3341926780515707 0.7542981933396602 0.08991317088612467 62770608.77076549 3.6746117508562857 33655.92712587376 0.03077966993359725 7.420353801954555e-11 10.129575387096528 0.33424479077266533 EEEK(ub)NEKLEGDAALNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEEKNEKLEGDAALNR 16 2 Q9Y2Z0;Q9Y2Z0-2 Q9Y2Z0 SUGT1 Suppressor of G2 allele of SKP1 homolog 1 3704280.0 822980.0 1738600.0 1142700.0 True False 1078934.7497496582 1479207.6570097196 1024464.3655523969 1.0 1.3709889846007235 0.9495146632269469 20.041176187570823 -6.674292624506465 1.9221060024054135 1.2359273175822447 0.951183611373037 0.2981214374083192 0.15743520305774764 0.4513971106082105 3.219077259475523 0.0658441838093597 0.17494357179365672 2.1169342794683596e-07 6.674292624506465 -0.28474370620920775 EEEK(ub)NEKLEGDAALNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEEKNEKLEGDAALNR 16 2 Q9Y2Z0;Q9Y2Z0-2 Q9Y2Z0 SUGT1 Suppressor of G2 allele of SKP1 homolog 1 5605600.0 1514800.0 1492000.0 2598800.0 True False 1466713.5031595975 2087763.3806772155 1918096.317671158 1.0 1.4234295765190346 1.3077511821764718 20.484155662601047 -10.283084546622634 5.256203075146578 0.9999376683183184 1.3655903793477324 0.9301555595254772 0.047225506734105055 3.450372059492341e-05 4.706055241643776e-06 0.04573367070466366 0.015241966758094735 5.210932569870708e-11 10.283084546622634 0.365652711029414 EEEK(ub)VNEEQWSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEEKVNEEQWSLR 13 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 16219100.0 4721700.0 6031800.0 5465600.0 True False 6190194.425007849 5131878.951772255 4900072.141737268 1.0 0.829033564929707 0.7915861450072395 22.56155329242924 -13.999999999999998 0.21339757152966288 2.002829722828735 0.7702426565289198 0.9994921862332866 0.002044301961540054 12.828429337786599 0.14639448343392195 5.402890902939296 0.02166566158064373 1.0000000000000041e-14 13.999999999999998 -1.232587066299815 EEEK(ub)VNEEQWSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEEKVNEEQWSLR 13 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 13729800.0 3662500.0 3332200.0 6735100.0 True False 3546235.9422511444 4662764.837193443 4970975.261331004 1.0 1.314849015441857 1.4017610058329728 21.757857095800965 -12.684772468057538 0.19923766009193114 1.4514037665852198e-08 1.4621599797923799 0.9994347408986038 0.004103428416826297 7.201198216676696 0.13211502606844627 2.911928183505501 0.05551952727928226 2.066462516060023e-13 12.684772468057538 1.4621599652783421 EEEK(ub)VNEEQWSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEEKVNEEQWSLR 13 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 14505200.0 4721700.0 5886600.0 3896900.0 True False 6467440.089144676 5626510.5476169465 2976532.479174758 1.0 0.8699749004340691 0.46023348313202644 22.624763353952133 -6.950340318797294 0.5550997501740779 1.0055027414694926 0.3052876098159692 0.9992276867839296 0.006392102816819841 0.08334947222791281 0.03539974231703537 0.0068932485378185564 0.03402548643614437 1.1211395704640659e-07 6.950340318797294 -0.7002151316535234 down EEEK(ub)VNEEQWSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEEKVNEEQWSLR 13 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 14800400.0 3662500.0 6868400.0 4269500.0 True False 3045531.0262605343 6831398.565929349 5162232.710062423 1.0 2.243089466836693 1.6950189197057328 21.53826237123524 -10.123549102318846 5.499655121011365 0.9999853389858138 1.9690541932714483 0.806513847056192 0.22374886392063753 4.0222791989944156e-05 6.410131020344174e-06 0.2166471782166688 0.07221463530800137 7.524036569009331e-11 10.123549102318846 0.9690688542856345 EEELVK(ub)VR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEELVKVR 8 1 P35579;P35579-2 P35579 MYH9 Myosin-9 1 17909700.0 7557600.0 5088200.0 5263900.0 True False 11465431.734569062 4180170.9557119445 4223487.85775067 1.0 0.3645890580036723 0.3683671016954874 23.450787345305088 -10.018079656384508 5.217547188264355 1.0000047454854424 0.36647807984751085 0.9999733273338789 0.0015423798861908373 8.558682096471581e-08 1.6109580740289073e-08 0.0014934141327970622 0.0004978009666179688 9.592246786068249e-11 10.018079656384508 -0.6335266656379315 EEELVK(ub)VR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEELVKVR 8 1 P35579;P35579-2 P35579 MYH9 Myosin-9 1 19447800.0 7557600.0 7061400.0 4828800.0 True False 9783462.182567969 6668426.882530532 3950007.947672064 1.0 0.681601948072354 0.40374336548365575 23.221913667397537 -7.282891591092676 0.21146311682137947 1.1634894040118253 1.5788584185749676e-11 0.9999749113688722 0.0012201846603440427 0.10407749289102203 0.012615881534406804 0.017381690761436988 0.04539184564181897 5.213248283507035e-08 7.282891591092676 -1.1634894039960368 down EEETLDTIK(ub)QYYVLCSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEETLDTIKQYYVLCSSR 18 1 Q9NUU7;I3L0H8;F6QDS0;Q9UMR2;H3BQK0;Q9UMR2-4;Q9UMR2-2;Q9NUU7-2;I3L352;Q9UMR2-3 Q9NUU7 DDX19A;DDX19B ATP-dependent RNA helicase DDX19A;ATP-dependent RNA helicase DDX19B 1 5701300.0 0.0 1602000.0 4099300.0 True False 0.0 1531218.3428944314 3131129.767733604 0.0 EEETSIDVAGK(ub)PNEVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEETSIDVAGKPNEVTK 17 1 P53985 P53985 SLC16A1 Monocarboxylate transporter 1 1 7009100.0 2456600.0 2807200.0 1745300.0 True False 3220626.3897482385 2388376.702379898 1564713.0980997607 1.0 0.7415876333816545 0.4858412335812962 21.618909879247003 -6.9712531075891855 0.22626366500415948 1.108996196082408 0.11115775413539362 0.9999905747045387 0.0006443971664867314 0.07589815551584048 0.00755885587379286 0.0067561055388270135 0.025588664004753865 1.0684320136768039e-07 6.9712531075891855 -0.9978384419470143 down EEETSIDVAGK(ub)PNEVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEETSIDVAGKPNEVTK 17 1 P53985 P53985 SLC16A1 Monocarboxylate transporter 1 1 6342100.0 2456600.0 1924800.0 1960700.0 True False 3364871.407118789 1839755.9715375805 1497623.0418840472 1.0 0.5467537236773317 0.44507586195289545 21.682119940769894 -13.999999999999996 0.2100165231823099 3.6214622937097154 0.38519724662164306 0.9994900206220473 0.0054475448156240305 12.747057531317061 0.1452538308832824 13.78870250247125 0.06022189246742046 1.0000000000000082e-14 13.999999999999996 -3.2362650470880725 EEETSIDVAGK(ub)PNEVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEETSIDVAGKPNEVTK 17 1 P53985 P53985 SLC16A1 Monocarboxylate transporter 1 1 5229500.0 1762200.0 2227500.0 1239800.0 True False 1465347.3786966035 2215500.0153758675 1499036.4478124834 1.0 1.5119281936727587 1.0229905001405508 20.482811283196913 -10.621754257970634 2.8342918512777913 0.9773693858988655 1.2674593465225539 0.2851916469970752 0.19960798240698654 54656998.446714625 56262398.492843136 9189499.026353203 0.07372329480624416 2.389162788999777e-11 10.621754257970634 0.2900899606236884 EEETSIDVAGKPNEVTK(ub)AAESPDQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEETSIDVAGKPNEVTKAAESPDQK 25 2 P53985 P53985 SLC16A1 Monocarboxylate transporter 1 1 9653600.0 4094200.0 2619200.0 2940200.0 True False 5367535.848289203 2228425.569561638 2635976.308389914 1.0 0.41516733796419913 0.49109617204141826 22.355828490802047 -10.582561962143393 6.4353919757671445 1.0011259142265487 0.45313175500329905 0.9857480187688921 0.03099781670893901 0.0005016319538504424 3.2538754579602516e-05 0.030066902536724255 0.010004502323542563 2.6147973602584175e-11 10.582561962143393 -0.5479941592232497 EEETSIDVAGKPNEVTK(ub)AAESPDQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEETSIDVAGKPNEVTKAAESPDQK 25 2 P53985 P53985 SLC16A1 Monocarboxylate transporter 1 1 8080000.0 2553900.0 3310500.0 2215600.0 True False 2472827.8424341814 4632399.91402944 1635267.8934247417 1.0 1.873320833151667 0.6612946786522067 21.237730372532813 -6.71332619203753 1.7830280853244427 1.5350483020636332 0.6638107185845639 0.481054524510781 0.36782589326124715 0.3684158347533356 2.285097678327471 0.16402991306926687 0.4150908788073689 1.9349680926635324e-07 6.71332619203753 -0.8712375834790693 EEEVSCSGPLSQK(ub)QAEFFLSQQASLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEEVSCSGPLSQKQAEFFLSQQASLLK 27 1 F5H0F9;Q9UJX4-3;Q9UJX4;F5GY68;Q9UJX4-2 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 90260000.0 12287000.0 13877000.0 64096000.0 True False 18640277.300022483 11400540.928504124 51427397.50572526 1.0 0.6116079039494962 2.7589395092133757 24.151919986456495 -6.860093971941729 1.1853497656158287 0.7892438139906099 2.8630676225679146 0.9537501101312464 0.20092219484024137 0.1466989912285384 0.39162735197450876 0.13220676056874497 0.3086243573064158 1.380085611587308e-07 6.860093971941729 2.0738238085773046 up EEEVSCSGPLSQK(ub)QAEFFLSQQASLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEEVSCSGPLSQKQAEFFLSQQASLLK 27 1 F5H0F9;Q9UJX4-3;Q9UJX4;F5GY68;Q9UJX4-2 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 22864400.0 3569200.0 4843200.0 14452000.0 True False 2967947.9423697186 4817108.720300066 17473846.381501865 1.0 1.6230435350742405 5.887517813924359 21.50103435671965 -6.933116198952966 0.7207532833203139 0.9420501604838912 6.836775386746568 0.9971160459157883 0.11664654589475175 0.09105177062017268 0.06998782644244778 0.10831361595097119 0.3794666676968412 1.1664974696010029e-07 6.933116198952966 5.894725226262677 up EEEVSCSGPLSQK(ub)QAEFFLSQQASLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEEVSCSGPLSQKQAEFFLSQQASLLK 27 1 F5H0F9;Q9UJX4-3;Q9UJX4;F5GY68;Q9UJX4-2 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 77894000.0 12287000.0 16198000.0 49409000.0 True False 15905763.71297932 15296567.060813652 40417068.979151964 1.0 0.9616996289421453 2.541032905334252 23.923046308548944 -6.901342057439243 0.9527336186758524 0.9367331582051662 2.7114104843669256 0.9872225596952443 0.0831551904339373 0.11042450804699495 0.17189612363227175 0.06529133481369936 0.17105187977780942 1.2550410834263878e-07 6.901342057439243 1.7746773261617594 up EEFASTCPDDEEIELAYEQVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEFASTCPDDEEIELAYEQVAK 22 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 8797220.0 4818700.0 969520.0 3009000.0 False True 4665733.006123023 1356654.3919800085 2220852.631934938 1.0 0.2907698297780045 0.4759922243772686 22.153672321617737 -10.863101934711944 11.013258692494265 1.0191568048614297 0.3833810270820826 0.9366164897062776 0.07561672595077264 0.02967132109176814 0.0003688225375452144 0.06107752598675891 0.024405193358506053 1.3705600396737857e-11 10.863101934711944 -0.6357757777793471 EEFEHQQK(ub)ELEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEFEHQQKELEK 12 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 207212000.0 93874000.0 78575000.0 34763000.0 True False 123069723.07710905 66851916.28295107 31166058.230242364 1.0 0.5432035972085933 0.2532390376040364 26.874900640831367 -8.432618479556798 0.23595654803572105 1.24709639296444 6.272952782372547e-11 0.9994987117966608 0.006882282794455987 0.1348052680498978 0.05895142670122954 0.12761635752321024 0.11277147460371588 3.6930188164087758e-09 8.432618479556798 -1.2470963929017105 down EEFEHQQK(ub)ELEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEFEHQQKELEK 12 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 169862000.0 62404000.0 71988000.0 35470000.0 True False 60423019.17822252 100733183.81246063 26179342.922808956 1.0 1.6671325793128617 0.43326770622949 25.84859493772831 -6.759847823683206 1.6129250798254011 1.3875795894826548 0.4287749439944441 0.6903928076693109 0.28059260680836773 0.28317232332593 1.4518736495480538 0.13725861599698114 0.3299191812146739 1.738409858975972e-07 6.759847823683206 -0.9588046454882106 EEFEHQQK(ub)ELEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEFEHQQKELEK 12 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 174118000.0 108550000.0 41730000.0 23838000.0 True False 164678286.06799406 34282955.46202187 19126408.851433426 1.0 0.20818139586336704 0.11614408497994884 27.295075097725753 -13.999999999999998 0.303710722435573 8.378955086597482 0.09435711348131087 0.9996580933272006 0.007336070654985093 16.83419064721516 0.17513383623853346 78.22451624154854 0.03273977585223803 1.0000000000000041e-14 13.999999999999998 -8.284597973116172 EEFEHQQK(ub)ELEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEFEHQQKELEK 12 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 190886000.0 93874000.0 66267000.0 30745000.0 True False 128581754.64946233 63339104.82433544 23483664.213150952 1.0 0.4925979194871743 0.18263605343675524 26.93811070235426 -8.481999832702394 0.2830560852047851 1.192772225018988 1.2020405511551001e-11 0.9990075972766912 0.010613697877667427 0.16054466656967273 0.07584740231485378 0.12198084281983981 0.10119817928438671 3.2960983914873786e-09 8.481999832702394 -1.1927722250069677 EEFEHQQK(ub)ELEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEFEHQQKELEK 12 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 175247000.0 62404000.0 87672000.0 25171000.0 True False 51891690.96594185 87199693.53447057 30434139.72244553 1.0 1.6804172674138231 0.586493505143635 25.629000213162588 -6.738518718011273 1.692410915181264 1.405543586239266 0.586092371485332 0.5981635064287645 0.28589269949104584 0.3204952634928295 1.8019355285409733 0.13367741039185943 0.32853033387080965 1.8259180506511722e-07 6.738518718011273 -0.819451214753934 EEFEHQQK(ub)ELEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEFEHQQKELEK 12 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 160910000.0 108550000.0 36683000.0 15677000.0 True False 140520114.8403929 34641558.80305145 12823946.859603835 1.0 0.24652384352516654 0.09126057770568771 27.066201419818203 -13.99999999999957 0.22203292343131767 5.587745511668064 0.009810575571571157 0.9995000112762753 0.00887445699939881 13.055711539764621 0.14925802524354917 26.29030907393021 0.08478885783036437 1.0000000000009899e-14 13.99999999999957 -5.577934936096494 EEFTAFLHPEEYDYMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEFTAFLHPEEYDYMK 16 0 O43852;O43852-3;O43852-6;O43852-10;O43852-15;H0Y875;O43852-2;O43852-4 O43852;O43852-2 CALU Calumenin 0 6324600.0 1466600.0 2671900.0 2186100.0 False True 1922726.8025746036 2273262.934984628 1959903.3425519362 1.0 1.182311981057654 1.0193353210282146 20.87472235614608 -10.749180060651481 2.9151280514585785 0.9812794746631212 1.1008236510447942 0.3378732770550301 0.06653494333208856 49680576.152788915 30716981.465076506 6568482.037936876 0.02434929644266662 1.781639937521098e-11 10.749180060651481 0.11954417638167303 EEFTAFLHPEEYDYMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEFTAFLHPEEYDYMK 16 0 O43852;O43852-3;O43852-6;O43852-10;O43852-15;H0Y875;O43852-2;O43852-4 O43852;O43852-2 CALU Calumenin 0 11326900.0 3940100.0 2248300.0 5138500.0 False True 3815023.6822016994 3146057.91472961 3792572.6983043095 1.0 0.8246496422569989 0.994115112836093 21.863260582108463 -10.660169103981358 7.999335800604302 1.0001732970662776 0.9093823775497604 0.27601430996931 0.06918398865656925 0.00021422886388643768 9.101019299861642e-06 0.06711454343063566 0.022329036324257943 2.1869099272346278e-11 10.660169103981358 -0.09079091951651719 EEFTAFLHPEEYDYMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEFTAFLHPEEYDYMK 16 0 O43852;O43852-3;O43852-6;O43852-10;O43852-15;H0Y875;O43852-2;O43852-4 O43852;O43852-2 CALU Calumenin 0 7812900.0 1466600.0 2288100.0 4058200.0 False True 2008841.6533747541 2187004.176265137 3099736.741252538 1.0 1.088689181942777 1.5430468280290455 20.93793241766897 -6.939264732661581 0.6663721221538556 0.9948295977660832 1.6629657579217487 0.9980659607126268 0.01046064091407724 0.08810371654198107 0.05614995160180298 0.01012678126287889 0.039234049647465186 1.1500991099104135e-07 6.939264732661581 0.6681361601556656 EEFYTK(ub)AESLIGVYPEQGDCVISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEFYTKAESLIGVYPEQGDCVISK 24 1 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 27037300.0 11755000.0 9138700.0 6143600.0 True False 11381843.959361672 12787830.567690935 4534406.855950637 1.0 1.1235288950849502 0.3983894764451629 23.440230970144373 -6.8630330722518815 1.1702426289634764 1.0676468507925307 0.3611727747049289 0.957225785510279 0.06551170149491171 0.14371415382167868 0.37226166625147644 0.04360407587421093 0.10216322368367745 1.3707773751980893e-07 6.8630330722518815 -0.7064740760876018 down EEFYTK(ub)AESLIGVYPEQGDCVISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEFYTKAESLIGVYPEQGDCVISK 24 1 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 121433000.0 44529000.0 50991000.0 25913000.0 True False 67553748.50595759 41891257.65549861 20791284.191928647 1.0 0.6201174410300001 0.30777395261929924 26.009532490030615 -7.697813947876417 0.25017152949711513 1.1486302025618604 2.7201834443806315e-21 0.9997739056324153 0.0042560305609265926 0.12808329016606015 0.03294036956228807 0.04038298429100946 0.07955411016085069 2.0053309288419553e-08 7.697813947876417 -1.1486302025618604 down EEFYTK(ub)AESLIGVYPEQGDCVISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEFYTKAESLIGVYPEQGDCVISK 24 1 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 32941600.0 11755000.0 4407600.0 16779000.0 True False 9774803.33479659 4383855.383959895 20287411.32266949 1.0 0.4484852772796089 2.075480255490139 23.22063624557865 -6.815245730663498 1.3923427535708395 0.7012397499773528 2.1074998837577614 0.8731006042193125 0.24066919843132387 0.19972569649124897 0.7620556208991979 0.1358755165844725 0.3136331137556245 1.5302213933028732e-07 6.815245730663498 1.4062601337804086 up EEFYTK(ub)AESLIGVYPEQGDCVISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEFYTKAESLIGVYPEQGDCVISK 24 1 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 94949000.0 44529000.0 31664000.0 18756000.0 True False 57643668.29781525 29901870.565107025 15342600.45281173 1.0 0.5187364275746541 0.26616280514183077 25.780658812123065 -9.350204053983713 0.19204859162569865 1.4814559351375072 1.7094789074723053e-24 0.9995704104443788 0.006309122220395709 0.7746193854163573 0.0721162148464135 0.3665742279713417 0.14800584532978067 4.4647376642056496e-10 9.350204053983713 -1.4814559351375072 EEGCTHVIVTTACGSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEGCTHVIVTTACGSLR 17 0 B4DUC8;Q13126;Q13126-4;Q13126-3;Q13126-2;J3QSB7;Q13126-7;Q13126-6;Q13126-5;F2Z2F3;A0A2R8Y4K0 B4DUC8 MTAP S-methyl-5-thioadenosine phosphorylase;Purine nucleoside phosphorylase 0 14687800.0 4110200.0 7122200.0 3455400.0 False True 5388512.003233417 6059595.522118152 3097868.35453728 1.0 1.1245396722661185 0.5749023761436145 22.361455507992172 -6.847157058617916 1.248705797088779 1.0663308935009521 0.5541025217718918 0.9360720805169652 0.059494644334367935 0.16060902490185136 0.48334576177332383 0.03730786656322918 0.08619166674433151 1.4218145079541623e-07 6.847157058617916 -0.5122283717290603 EEGCTHVIVTTACGSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEGCTHVIVTTACGSLR 17 0 B4DUC8;Q13126;Q13126-4;Q13126-3;Q13126-2;J3QSB7;Q13126-7;Q13126-6;Q13126-5;F2Z2F3;A0A2R8Y4K0 B4DUC8 MTAP S-methyl-5-thioadenosine phosphorylase;Purine nucleoside phosphorylase 0 11648100.0 4110200.0 4691900.0 2846000.0 False True 5629852.013978527 4484596.343961541 2173833.415209874 1.0 0.7965744628502851 0.3861262089682639 22.424665569515064 -6.959872509117036 0.4372300746786004 1.0151070034423313 0.15166434926268832 0.9997654328214272 0.0039103579531754706 0.07974674176121167 0.021300127820612136 0.0053934855851113335 0.034026584728664024 1.0968001240046526e-07 6.959872509117036 -0.8634426541796429 down EEGDLGPVYGFQWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEGDLGPVYGFQWR 14 0 P04818;P04818-2 P04818 TYMS Thymidylate synthase 0 5893200.0 1178100.0 1995600.0 2719500.0 False True 1544500.5087366276 1697864.2587878725 2438112.227286025 1.0 1.0992966652867557 1.5785765129209022 20.55870891549315 -6.940595419894309 0.6540055040601924 0.9946705110813037 1.7101167354142328 0.9982407982126027 0.01059530339602792 0.08749612120250558 0.053381480404100054 0.010360841690763034 0.04114365245042719 1.1465805757455508e-07 6.940595419894309 0.7154462243329291 EEGDLGPVYGFQWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEGDLGPVYGFQWR 14 0 P04818;P04818-2 P04818 TYMS Thymidylate synthase 0 4576100.0 1178100.0 1657800.0 1740200.0 False True 1613675.4069554037 1584552.914388506 1329200.600543999 1.0 0.9819526947976207 0.8237100192608522 20.62191897701604 -6.928431003976108 0.7595582499854566 1.002551682758609 0.7924843748206241 0.996220823992727 0.004868422117776667 0.09346076236005954 0.08173101979262244 0.0043946573136745114 0.014443740192532889 1.1791498389746095e-07 6.928431003976108 -0.2100673079379849 EEGFPIRPHYFWPLLVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEGFPIRPHYFWPLLVGR 18 1 P42704;B8ZZ38;A0A0C4DG06 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 23216900.0 6345700.0 9563300.0 7307900.0 False True 8319274.151846207 8136492.91745144 6551748.610326741 1.0 0.9780291848713504 0.7875384908276862 22.98802622951588 -6.92863060387347 0.7579465796423209 1.0030487541042516 0.7497612078485958 0.9962622173636464 0.005832465775237862 0.09335517542501288 0.08120906561553852 0.0052710018150547355 0.017367730184593165 1.1786080312378944e-07 6.92863060387347 -0.25328754625565586 EEGFPIRPHYFWPLLVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEGFPIRPHYFWPLLVGR 18 1 P42704;B8ZZ38;A0A0C4DG06 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 73381000.0 23057000.0 15213000.0 35111000.0 False True 22325068.155763734 21287630.234746978 25914375.792578127 1.0 0.9535303581705341 1.1607747672603512 24.41216124394022 -6.847824191553147 1.2454645015211385 0.9752398121093755 1.1687218519876992 0.937088957383108 0.022271192076616517 0.15986780642239698 0.4782891796506468 0.013999652930007357 0.032355761929911846 1.4196320922006882e-07 6.847824191553147 0.19348203987832369 EEGFPIRPHYFWPLLVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEGFPIRPHYFWPLLVGR 18 1 P42704;B8ZZ38;A0A0C4DG06 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 31194200.0 9421000.0 9027200.0 12746000.0 False True 14292345.767356722 7416225.630164478 10226747.513229746 1.0 0.518894921161431 0.7155401695211798 23.768739386047297 -10.200902490045271 5.435002530094836 1.0000173722085643 0.6172175453412571 0.8347693447569965 0.08028008647087982 1.6899912110732163e-05 2.4847190432053422e-06 0.07773438395863667 0.025910286494459374 6.296475385812217e-11 10.200902490045271 -0.3827998268673073 EEGFPIRPHYFWPLLVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEGFPIRPHYFWPLLVGR 18 1 P42704;B8ZZ38;A0A0C4DG06 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 63848300.0 6345700.0 17494600.0 40008000.0 False True 8691876.776094478 16721630.725094182 30558934.390624274 1.0 1.9238228009725324 3.515803914141006 23.051236291038773 -6.962849784401054 0.3932200272533277 0.9056666088711771 4.59145723520386 0.9998617205967516 0.012218735610304662 0.07869847442243623 0.017482050638462126 0.020521810000326036 0.13373515431668245 1.0893068021914554e-07 6.962849784401054 3.685790626332683 EEGFPIRPHYFWPLLVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEGFPIRPHYFWPLLVGR 18 1 P42704;B8ZZ38;A0A0C4DG06 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 62036700.0 23057000.0 9912100.0 29067600.0 False True 19172917.09829056 9858701.549902184 35145500.76660277 1.0 0.5141993521049114 1.833080515939659 24.192566519374495 -6.806989485988668 1.427105643545239 0.7342860668862987 1.8546090153001258 0.8518352776135933 0.20963505771156948 0.21093274009838225 0.8472267017421494 0.1155223695382745 0.267615423389863 1.5595902591233277e-07 6.806989485988668 1.120322948413827 EEGFPIRPHYFWPLLVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEGFPIRPHYFWPLLVGR 18 1 P42704;B8ZZ38;A0A0C4DG06 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 30435900.0 9421000.0 15380800.0 5634100.0 False True 12195670.215673344 14524844.95919019 4608751.610747847 1.0 1.1909837427813923 0.3779006425431937 23.539865708139747 -6.844797608776347 1.2599105526343035 1.1016269705748587 0.34851228373947846 0.9323931170944592 0.09026228088187574 0.16327086089746334 0.5013559986767806 0.05612676459462436 0.12952240353860706 1.4295600111669785e-07 6.844797608776347 -0.7531146868353802 down EEIIK(ub)TLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEIIKTLSK 9 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 8004300.0 1750000.0 4393900.0 1860400.0 True False 2294266.947024109 3738347.2472880543 1667903.654216924 1.0 1.6294299371470529 0.7269876142270018 21.129601833712652 -6.719165139476661 1.7623290262312172 1.3832751033202342 0.7284590416227489 0.5085935990312602 0.26489330590699217 0.35692993814102364 2.1660279197632217 0.11936866158717192 0.2999535438762806 1.9091271793163628e-07 6.719165139476661 -0.6548160616974853 EEIIK(ub)TLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEIIKTLSK 9 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 7729800.0 2167500.0 2927200.0 2635100.0 True False 2098693.8989295135 4096046.225146339 1944888.258694501 1.0 1.951712075417773 0.9267136382711816 21.001060329713187 -6.66284700454324 1.9630583314752104 1.6111699165472135 0.9309845911291252 0.24770251488895967 0.40494423609726315 0.47770432205230046 3.5418376954779003 0.16649817610090442 0.44897875767351 2.1734667238617415e-07 6.66284700454324 -0.6801853254180883 EEIIK(ub)TLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEIIKTLSK 9 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 5655100.0 1750000.0 2258000.0 1647100.0 True False 2397022.2919717864 2158234.093792525 1258088.9030893135 1.0 0.9003813193648548 0.5248549032284601 21.192811895235543 -6.946238645608217 0.59871685452167 1.0042419661101534 0.4018132549537542 0.9988720677049413 0.00687103019831991 0.08503221229223228 0.0424908783529462 0.007060974894707922 0.03154515247952613 1.1317782781091114e-07 6.946238645608217 -0.6024287111563992 EEIIK(ub)TLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEIIKTLSK 9 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 7382500.0 2167500.0 4062500.0 1152500.0 True False 1802372.286530975 4040614.50615689 1393482.4214420763 1.0 2.2418312444949198 0.7731379537154953 20.781465605147464 -6.682574475820304 1.8925577453954598 1.783884532214238 0.7785841330572112 0.3360421624130081 0.5260214978858241 0.43282024982727907 2.9994093535854356 0.2228342537522771 0.5858183659572456 2.0769475257106938e-07 6.682574475820304 -1.0053003991570268 EEIIK(ub)TLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEIIKTLSK 9 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 10388200.0 5475600.0 3036600.0 1876000.0 True False 7088272.140212387 2867610.5406140727 1534587.2493855197 1.0 0.404557060435909 0.21649666082650412 22.75700256370778 -13.99999999999938 0.16131275967198877 3.9407560511057427 0.03427590543131187 0.9995329763729108 0.007217235374620196 12.018684038463752 0.1269665214920368 11.057534817214675 0.16635570743576167 1.0000000000014275e-14 13.99999999999938 -3.906480145674431 EEIK(ub)FSHTE ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEIKFSHTE 9 1 A0A494C105;Q9H3U5-4;Q9H3U5-3;Q9H3U5;Q9H3U5-5;Q9H3U5-6 A0A494C105 MFSD1 Major facilitator superfamily domain-containing protein 1 1 9736300.0 4059400.0 2839800.0 2837100.0 True False 5321912.711285517 2416112.909453698 2543544.107384881 1.0 0.453993336705833 0.47793796053646354 22.343513417146116 -10.27668638782976 5.595981975044719 1.0000478541115483 0.46596564862114864 0.9984944862163609 0.009775351744694861 5.8367114386107605e-06 7.544521776808191e-07 0.009465788214595839 0.003154981209204477 5.288269897912283e-11 10.27668638782976 -0.5340822054903996 EEIK(ub)FSHTE ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEIKFSHTE 9 1 A0A494C105;Q9H3U5-4;Q9H3U5-3;Q9H3U5;Q9H3U5-5;Q9H3U5-6 A0A494C105 MFSD1 Major facilitator superfamily domain-containing protein 1 1 9505000.0 2398300.0 2514500.0 4592200.0 True False 2322167.2792630484 3518552.962944272 3389365.056953013 1.0 1.5152021968292062 1.4595697248945154 21.147040471015476 -10.454325334603526 5.9943017336999125 0.9997388233048491 1.487385960861861 0.9903228212466998 0.022711861561616715 7.931485081453282e-05 7.220175789202729e-06 0.02200216147686662 0.007330221799125769 3.5129718149021484e-11 10.454325334603526 0.48764713755701183 EEIK(ub)FSHTE ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEIKFSHTE 9 1 A0A494C105;Q9H3U5-4;Q9H3U5-3;Q9H3U5;Q9H3U5-5;Q9H3U5-6 A0A494C105 MFSD1 Major facilitator superfamily domain-containing protein 1 1 8492500.0 3420100.0 2814900.0 2257500.0 True False 4427386.870249909 2658248.3405040335 1846658.1639060797 1.0 0.6004102235488595 0.4170988933257244 22.078024012650403 -13.999999999999993 0.10468290160626338 2.9491489557600454 0.053535499918031706 0.9997700855014096 0.003690157062776622 12.046512552077527 0.09726885382789954 5.0165409123972005 0.3234957407822674 1.0000000000000164e-14 13.999999999999993 -2.895613455842014 EEILECQVMWEPDSKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEILECQVMWEPDSKK 16 1 Q86V21;Q86V21-2;E7EW25 Q86V21 AACS Acetoacetyl-CoA synthetase 1 19719200.0 9245700.0 8222200.0 2251300.0 True False 12121202.235486174 6995479.809884569 2018357.0719944974 1.0 0.5771275550047766 0.16651459424425175 23.531029463117722 -7.734137339468171 0.3847437134204584 1.053535813517 2.1062086347131467e-22 0.9984612830858717 0.013348035620923042 0.11801604236827813 0.06278170082047167 0.030876183677193133 0.07724232407337264 1.84443205147581e-08 7.734137339468171 -1.053535813517 down EEILECQVMWEPDSKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEILECQVMWEPDSKK 16 1 Q86V21;Q86V21-2;E7EW25 Q86V21 AACS Acetoacetyl-CoA synthetase 1 38770000.0 14620000.0 5479000.0 18671000.0 True False 18925878.203284584 5174088.833571921 15273069.58063807 1.0 0.2733869878056152 0.8069939696635811 24.17385691026813 -10.036828115428087 6.783233880834394 1.00000013463495 0.5401904787358272 0.4974969091301835 0.217844138123099 4.435800220173664e-07 6.301646033793115e-08 0.21092674261502514 0.07030889325163879 9.186961250390051e-11 10.036828115428087 -0.4598096558991229 EEIQSSISGVTAAYNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEIQSSISGVTAAYNR 16 0 P46940;H0YLE8;A0A0J9YXZ5;A0A087WWP1 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 12500800.0 3585300.0 4293100.0 4622400.0 False True 4700363.020094587 3652586.2143727336 4144118.3891917383 1.0 0.7770859822438207 0.8816592189741858 22.164340753149627 -10.20646535200076 4.998803877412729 1.0000184214849204 0.8293726006088157 0.7802066782930699 0.042691845124095 8.765637821680112e-06 1.391526552776665e-06 0.04134066181204939 0.013778733765280762 6.216338397012121e-11 10.20646535200076 -0.1706458208761047 EEIQSSISGVTAAYNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEIQSSISGVTAAYNR 16 0 P46940;H0YLE8;A0A0J9YXZ5;A0A087WWP1 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 10916200.0 2346800.0 1047600.0 7521800.0 False True 2272302.118573371 1465912.1431618289 5551614.930836892 1.0 0.6451220245669527 2.443167607625339 21.115723233387993 -6.855440570268016 1.2085121646576324 0.8093346476677012 2.5229721538296737 0.9478595630047255 0.1775541974304974 0.15157205832524345 0.42326417090692936 0.11478171054495685 0.26671313195775026 1.3949525326951626e-07 6.855440570268016 1.7136375061619724 up EEIQSSISGVTAAYNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEIQSSISGVTAAYNR 16 0 P46940;H0YLE8;A0A0J9YXZ5;A0A087WWP1 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 10584200.0 3585300.0 3348600.0 3650300.0 False True 4910882.299089391 3200647.779660606 2788174.320288336 1.0 0.6517459765334005 0.5677542548322403 22.22755081467252 -13.999999999999998 0.1997697586047249 2.9342036536523106 0.5130822908041199 0.9994869206187273 0.004238813804874346 12.526390244632779 0.14172391606827783 9.466061694507916 0.053573642581130114 1.0000000000000041e-14 13.999999999999998 -2.421121362848191 EEIQSSISGVTAAYNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEIQSSISGVTAAYNR 16 0 P46940;H0YLE8;A0A0J9YXZ5;A0A087WWP1 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 5412300.0 2346800.0 1509400.0 1556100.0 False True 1951468.1808677702 1501268.5626075575 1881473.3154065185 1.0 0.7693020964041444 0.964132202539871 20.89612850882227 -10.09906249023239 6.23845118360075 1.0000003193887628 0.8667171495659476 0.3842313078459466 0.07953905776080772 3.533440481924864e-07 5.0955523141339173e-08 0.07701354628066358 0.02567112050671921 7.960448000242705e-11 10.09906249023239 -0.13328316982281518 EEK(ub)GLAAEDSGGDSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEKGLAAEDSGGDSK 15 1 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 5385500.0 1745400.0 2342000.0 1298100.0 True False 2288236.3024776424 1992582.7290444968 1163785.0642544546 1.0 0.8707941251028053 0.5085947911036717 21.12580461392706 -6.952965050326292 0.5252887664001276 1.0059126488495052 0.35716591615961935 0.9994138749529313 0.005035587611797651 0.08231659642403795 0.031201132990146326 0.005657819867776573 0.029934708660098473 1.1143842096042948e-07 6.952965050326292 -0.6487467326898858 EEK(ub)GLAAEDSGGDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEKGLAAEDSGGDSK 15 1 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 5467500.0 1745400.0 2248100.0 1474000.0 True False 2390721.547661457 2148771.5085274456 1125871.5579829065 1.0 0.8987962277034391 0.47093378945959025 21.18901467544995 -6.943604399949124 0.6251328925320427 1.0046706881880128 0.34219152206359216 0.9985989086136209 0.008583080904868012 0.08616010054150879 0.04740586074329112 0.00860378379636355 0.03628146572574991 1.1386640257935914e-07 6.943604399949124 -0.6624791661244206 down EEKDPGMGAMGGMGGGMGGGMF ddPTM_RPMI8226_Bortezomib_1h_R1 3 EEKDPGMGAMGGMGGGMGGGMF 22 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 24141400.0 4392300.0 10295700.0 9453400.0 False True 5758347.835093709 8759621.692324264 8475252.851415975 1.0 1.5212039882237705 1.4718202328390697 22.457223507375943 -10.095383068111596 4.877875109683988 0.9999807992272418 1.4965121105349497 0.9926352244526789 0.02016083372467548 4.2099909722879025e-06 7.807103796875329e-07 0.01952139723603798 0.006506881103373882 8.028176869242035e-11 10.095383068111596 0.4965313113077079 EEKDPGMGAMGGMGGGMGGGMF ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEKDPGMGAMGGMGGGMGGGMF 22 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 13572700.0 4619100.0 1061500.0 7892100.0 False True 4472469.198867509 1485362.485649372 5824922.2520750165 1.0 0.332112401361084 1.302395163179652 22.092640116040908 -6.721469472845627 1.7538958880735536 0.5943072507856224 1.3010224756813928 0.5194955739886518 0.2810000752443303 0.3524739360614362 2.1197568647982035 0.12717035466075402 0.31871060748688623 1.8990243224324614e-07 6.721469472845627 0.7067152248957704 EEKDPGMGAMGGMGGGMGGGMF ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EEKDPGMGAMGGMGGGMGGGMF 22 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 18812700.0 3163500.0 5931800.0 9717400.0 False True 4333131.440372996 5669713.462160547 7422350.256135086 1.0 1.308456376221188 1.712929865680735 22.0469785690307 -6.967395218342484 0.31423967093597865 0.9407264529245793 2.093596254923376 0.99995434807043 0.0019724584080852165 0.07715729939637897 0.012041152220839775 0.006280734632735902 0.035765082859877756 1.077965301590573e-07 6.967395218342484 1.1528698019987966 EELAK(ub)K(ub)CSITVSQVSNWFGNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EELAKKCSITVSQVSNWFGNK 21 2 P40426-4;P40426-3;P40426-2;P40426-5;P40426 P40426-4 PBX3 Pre-B-cell leukemia transcription factor 3 2 29277800.0 3091200.0 4812600.0 21374000.0 True False 4689576.3969910955 3953753.9289845773 17149419.531442992 1.0 0.8430940439570122 3.656922945630297 22.161026181284296 -6.893703763172899 1.0002412102087903 0.8619582014634782 3.9172318309355196 0.9831641050307467 0.16751900229954508 0.11618848675080101 0.20471773294604267 0.12695159657518235 0.3210092450198111 1.27730977814299e-07 6.893703763172899 3.0552736294720413 up EELAVLLLQSDPFFMPEICK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 EELAVLLLQSDPFFMPEICK 20 0 C9J6P4;Q7Z2W4;Q7Z2W4-2;Q7Z2W4-3 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 10456400.0 4099100.0 3279700.0 3077600.0 True False 5373959.795740861 2790381.544170467 2759159.4744237848 1.0 0.5192412392779692 0.5134313577504915 22.357554097466796 EELAVLLLQSDPFFMPEICK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 EELAVLLLQSDPFFMPEICK 20 0 C9J6P4;Q7Z2W4;Q7Z2W4-2;Q7Z2W4-3 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 14037000.0 4470400.0 5093500.0 4473100.0 True False 4328489.598973242 7127361.112251594 3301460.9198764265 1.0 1.6466162039391918 0.7627281628814735 22.04543226212609 -6.710577571702013 1.7929580070413567 1.3972833884563065 0.7647507743504859 0.4679434749232434 0.27245522025797975 0.3739090885856454 2.3434195879674675 0.12090615871739446 0.30696514190102225 1.9472532093805748e-07 6.710577571702013 -0.6325326141058206 EELAVLLLQSDPFFMPEICK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EELAVLLLQSDPFFMPEICK 20 0 C9J6P4;Q7Z2W4;Q7Z2W4-2;Q7Z2W4-3 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 9874900.0 4099100.0 3243700.0 2532100.0 True False 5614648.0440123025 3100382.60851852 1934070.1302364473 1.0 0.5521953618846863 0.34446863188495336 22.420764158989687 -12.14017802766013 0.12456421019078419 2.3861253108344034 2.5237917604614367e-22 0.9997340003605346 0.004461241235045548 5.8636383095595335 0.08932636616896282 2.3721882898168087 0.26469257031380217 7.241390573649472e-13 12.14017802766013 -2.3861253108344034 EELAVLLLQSDPFFMPEICK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EELAVLLLQSDPFFMPEICK 20 0 C9J6P4;Q7Z2W4;Q7Z2W4-2;Q7Z2W4-3 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 10592700.0 4470400.0 4489100.0 1633200.0 True False 3717335.6722989967 4464916.327283415 1974694.568936398 1.0 1.201106577637116 0.5312123367420146 21.825837537560368 -6.826223908404 1.3447385368338551 1.1077688086163637 0.5145423361804878 0.8981008227610288 0.08959343375214364 0.18551784048631567 0.6574229658252094 0.0523312234453727 0.12046226164625844 1.4920249706882115e-07 6.826223908404 -0.5932264724358759 EELAVLLLQSDPFFMPEICK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EELAVLLLQSDPFFMPEICK 20 0 C9J6P4;Q7Z2W4;Q7Z2W4-2;Q7Z2W4-3 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 1 19698200.0 8585600.0 5862200.0 5250400.0 True False 11114228.44747744 5535963.416712043 4294881.073653372 1.0 0.4980969612846605 0.38643087947577387 23.40590446380149 -13.999999999999915 0.21118602047811885 3.9169270899513555 0.3214108697122091 0.9994907105099569 0.006021944361798988 12.774722904888037 0.14564966229201412 15.470510325164778 0.06560014660318927 1.0000000000001963e-14 13.999999999999915 -3.5955162202391464 EELCK(ub)SIQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EELCKSIQR 9 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 3235940.0 1284000.0 1188500.0 763440.0 True False 1683336.434273687 1011180.432736714 684446.5522335886 1.0 0.6007001405948956 0.40660116320057454 20.682892114115262 -13.072893486491651 0.10389888166863519 2.6413058343445353 1.0076093836661568e-20 0.9998047182598333 0.003452143478657054 8.700244549245863 0.08722784995850065 3.283899628726677 0.3361678709732962 8.454861806449595e-14 13.072893486491651 -2.6413058343445353 EELCK(ub)SIQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EELCKSIQR 9 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 3153920.0 1284000.0 883130.0 986790.0 True False 1758729.4987952968 844110.396479625 753730.5255779871 1.0 0.47995464740759053 0.42856535134839163 20.746102175638153 -13.999999999999922 0.32720716652179976 6.566760549709006 0.41916404179273115 0.9997090154472938 0.0044030479730101345 18.590207135924913 0.18277198847667334 71.11463745331116 0.01664166395001163 1.00000000000018e-14 13.999999999999922 -6.147596507916274 EELDFQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EELDFQK 7 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 6969740.0 2557200.0 507540.0 3905000.0 False True 2476023.085740508 710203.3687861343 2882163.352511109 1.0 0.2868322887925468 1.1640292730344781 21.239593335220487 -6.690456378368022 1.864901043994757 0.5531050056600718 1.1610156680365054 0.37272113361220305 0.30158684098005206 0.41557227177779793 2.802567250023978 0.12935922759290114 0.33665349063403976 2.0395935112316077e-07 6.690456378368022 0.6079106623764335 EELDFQK(ub)NIYSEELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EELDFQKNIYSEELR 15 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 40129000.0 12148000.0 16459000.0 11522000.0 True False 15926145.641399357 14003381.35667949 10329813.966828316 1.0 0.8792699547012981 0.6486072775811111 23.92489382016042 -6.96092969606038 0.42212788520591593 1.0099651528175417 0.5091804752186723 0.9998031369775705 0.002045355182608574 0.07937068361616613 0.019916559659609673 0.0029880838068399246 0.01918979322923047 1.0941334711420456e-07 6.96092969606038 -0.5007846775988695 EELDFQK(ub)NIYSEELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EELDFQKNIYSEELR 15 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 64564000.0 31453000.0 17861000.0 15250000.0 True False 30454541.731501766 24992990.44388456 11255567.509806499 1.0 0.8206654581845882 0.36958584401103933 24.860154059663692 -6.955330697506389 0.4968883948779282 1.0092825377894599 0.1616159408784012 0.9995559310352974 0.005588878751920485 0.08141320257159512 0.02763049059869941 0.006593312404856604 0.037206688156902035 1.1083305454313199e-07 6.955330697506389 -0.8476665969110586 down EELDFQK(ub)NIYSEELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EELDFQKNIYSEELR 15 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 37926000.0 12148000.0 13498000.0 12280000.0 True False 16639443.887356147 12901613.728083048 9379716.914538743 1.0 0.7753632762863323 0.5637037498390274 23.988103881683312 -6.971844644045626 0.20949297192433117 1.1115353921085858 0.22162626075273556 0.9999934184723875 0.0004569814581901042 0.0757085298215568 0.006845286355684607 0.0063638168498837125 0.02195885548645311 1.0669777325706762e-07 6.971844644045626 -0.8899091313558503 EELDFQK(ub)NIYSEELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EELDFQKNIYSEELR 15 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 61744000.0 31453000.0 19928000.0 10363000.0 True False 26154563.104156327 19820643.908601724 12529855.386901734 1.0 0.7578273752717339 0.47906957332850897 24.64055933509797 -6.969283908888349 0.27475425649421203 1.065422613826468 0.16304035794716273 0.9999762442418357 0.0010373816012126734 0.07653578464867422 0.009858983023959789 0.005309660163910021 0.025760364876556502 1.0732875487225644e-07 6.969283908888349 -0.9023822558793052 down EELDFQK(ub)NIYSEELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EELDFQKNIYSEELR 15 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 83256500.0 39747000.0 33998000.0 9511500.0 True False 51453275.03050296 32105981.413356148 7780504.5962315295 1.0 0.623983242938818 0.15121495359856152 25.616759572621195 -7.528402123790318 0.4487113052245628 1.0250532753190276 7.560947786617519e-25 0.998057600739513 0.01530487451055832 0.11813567375279112 0.06073182132609331 0.020999116842720458 0.06883959212612159 2.9620874507938127e-08 7.528402123790318 -1.0250532753190276 down EELEEVIK(ub)DI ddPTM_RPMI8226_Bortezomib_1h_R1 1 EELEEVIKDI 10 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 11168000.0 2910800.0 8257200.0 0.0 True False 3816086.9882272934 7025257.946313507 0.0 1.0 1.8409585441806153 0.0 21.863662627474138 -6.791418870937572 1.5492165184143059 1.474155443595396 3.521889548618947e-20 0.7757792861233354 0.35632458841082665 0.24089256248166335 1.151367453560776 0.18268218790251894 0.4168605725612647 1.6165201744915008e-07 6.791418870937572 -1.474155443595396 EELEEVIK(ub)DI ddPTM_RPMI8226_Bortezomib_2h_R1 1 EELEEVIKDI 10 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 99212700.0 6565700.0 47122000.0 45525000.0 True False 6357275.447382483 65938060.3379837 33600636.779274836 1.0 10.37206282529928 5.285383189288962 22.599977168053297 -9.751185968185133 8.837607470669985 1.0000917674996075 7.828723007294095 0.7061393399151783 2.076628266214436 0.0 0.0 2.0106866126049963 0.6702288908408761 1.7734299221583156e-10 9.751185968185133 6.828631239794488 EELEEVIK(ub)DI ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EELEEVIKDI 10 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 33939500.0 2910800.0 7823700.0 23205000.0 True False 3987001.421412264 7478023.064483864 17724456.92197649 1.0 1.8756008022277104 4.4455607231005665 21.92687268899703 -6.951941431267655 0.537107061809005 0.9614266777844512 5.477829037389324 0.9993449656933842 0.03742398935798921 0.08271540101437082 0.03280752940197976 0.04132765216320573 0.2127336126915702 1.1170138775452693e-07 6.951941431267655 4.516402359604873 EELEEVIK(ub)DI ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EELEEVIKDI 10 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 46679700.0 6565700.0 22880000.0 17234000.0 True False 5459670.459827656 22756740.898675565 20837549.71898722 1.0 4.16815283378732 3.816631401530596 22.380382443487573 -10.270635199844383 5.112966854943312 0.9994417863554543 3.9923921176598203 0.9897563162992018 0.14350802378321786 0.000913300130591207 0.0001302810875250059 0.1389708421826629 0.04631701551286408 5.3624690688608555e-11 10.270635199844383 2.9929503313043657 EELEEVIKDI ddPTM_RPMI8226_Bortezomib_1h_R1 1 EELEEVIKDI 10 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 6565620.0 537220.0 2948400.0 3080000.0 False True 704300.6224458804 2508510.2127731824 2761311.145446212 1.0 3.561703813439325 3.920642773048799 19.425831832187757 -10.003541804420227 0.46562463855010483 7.165090095050415e-19 3.924976577539607 0.9990975724070758 0.03906708886964493 1.3045244410775534 0.21113958235497196 1.9137666383968983 0.07778702063931801 9.918778582319331e-11 10.003541804420227 3.924976577539607 EELEEVIKDI ddPTM_RPMI8226_Bortezomib_2h_R1 1 EELEEVIKDI 10 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 9494200.0 3422700.0 1950600.0 4120900.0 False True 3314048.2619912564 2729484.7522446197 3041512.6656499426 1.0 0.8236104415101668 0.9177635402999352 21.66016318178953 -10.076617519770563 4.489726437429438 1.0000092450120799 0.8706869908976712 0.7155124478660928 0.0384378416478681 53388233.10658512 0.0874972487552586 5102.572871080339 0.0131582955789855 8.382672134308598e-11 10.076617519770563 -0.12932225411440867 EELEEVIKDI ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EELEEVIKDI 10 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 13035320.0 537220.0 5572800.0 6925300.0 False True 735844.7518246182 5326575.269214785 5289686.771030545 1.0 7.238721559142579 7.188590742699614 19.48904189371065 -10.161626514916783 5.0837014083064265 0.9996601347593365 7.213656150928578 0.9999511847834472 0.020465820138413818 3583225.782627277 9.35260317342355 14255.338607741734 0.0070059945883247 6.892447790876789e-11 10.161626514916783 6.213996016169242 EELEFEVPFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EELEFEVPFR 10 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 9620800.0 1059700.0 4799200.0 3761900.0 False True 1389276.9621493977 4083178.067135076 3372654.6746928864 1.0 2.939066995552746 2.427633054157133 20.40590280873568 -10.286222536574591 5.984713206364781 0.9999099719437593 2.6833500248549127 0.9352528665613017 0.2087920322599688 0.00025084354148477027 2.9917171280224004e-05 0.2021725125712472 0.06738733864696968 5.1734167328543215e-11 10.286222536574591 1.6834400529111533 EELEFEVPFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EELEFEVPFR 10 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 2618200.0 1483800.0 1134400.0 0.0 False True 1436697.581191058 1587371.8358178486 0.0 1.0 1.1048754147006203 0.0 20.454324981827725 -6.957678168305567 1.1905290854493655 1.0610883083184173 8.229923666226868e-20 0.9742606077809262 0.0798914893079708 0.10457652318965675 0.2939879498524528 0.055933350167966765 0.10563643788592379 1.1023559021155974e-07 6.957678168305567 -1.0610883083184173 down EELEFEVPFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EELEFEVPFR 10 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 4236100.0 1059700.0 3176400.0 0.0 False True 1451499.727315714 3036056.1450498593 0.0 1.0 2.0916684226076265 0.0 20.46911287025857 -6.769674873769497 1.607062413446191 1.630027648117401 3.355423708693419e-11 0.7103601415841851 0.45971148792477584 0.2713261868252602 1.387990077107053 0.22666129882691624 0.5329430985354326 1.699515485993232e-07 6.769674873769497 -1.6300276480838467 EELEQTYHAK(ub)LENAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EELEQTYHAKLENAR 15 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 35524300.0 16292000.0 13275000.0 5957300.0 True False 21358969.771952428 11294421.745544724 5340895.742456724 1.0 0.5287905674353272 0.2500539960251328 24.348338725996374 -8.682197971417011 0.2249687978901958 1.300260249153212 7.54041302791089e-20 0.9994910885106163 0.006982187340801161 0.25244677269224913 0.06429263922624796 0.176151048592799 0.12144798625371542 2.078748881660775e-09 8.682197971417011 -1.300260249153212 down EELEQTYHAK(ub)LENAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EELEQTYHAKLENAR 15 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 42762000.0 18416000.0 12595000.0 11751000.0 True False 17831394.16040874 17624249.18205729 8673060.57755648 1.0 0.9883831305343822 0.4863927351689293 24.08791616973622 -6.9118856570311 0.882799325407042 1.014631037738152 0.41883342729532924 0.9916138418657839 0.021925634223923678 0.10318415065520681 0.1321025816230296 0.018119880731646387 0.050697082061233335 1.2249386640736197e-07 6.9118856570311 -0.5957976104428228 down EELEQTYHAK(ub)LENAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EELEQTYHAKLENAR 15 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 45354000.0 18169000.0 16873000.0 10312000.0 True False 27563701.331822947 13861881.320649285 8273828.680089843 1.0 0.502903479970791 0.30017117732071463 24.716266294435222 -13.948954731056311 0.1251696757628322 3.3385250958439836 2.1116038619143713e-20 0.9996736034509499 0.005311675041016827 11.705147577783274 0.10869409657496733 6.783916991093778 0.26546062445471547 1.1247222039450929e-14 13.948954731056311 -3.3385250958439836 EELEQTYHAK(ub)LENAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EELEQTYHAKLENAR 15 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 33856920.0 16292000.0 8932800.0 8632120.0 True False 22315592.674745318 8538119.359180631 6593391.040091872 1.0 0.3826077793955824 0.29546116637778796 24.411548787519266 -13.999999999999998 0.27581106314966375 5.917478893940642 0.2681249249613087 0.9995959495403252 0.0063038083416206495 15.176213613166784 0.16630931663803275 41.991069568816734 0.03517286035704827 1.0000000000000041e-14 13.999999999999998 -5.649353968979334 EELEQTYHAK(ub)LENAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EELEQTYHAKLENAR 15 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 43623500.0 18416000.0 18255000.0 6952500.0 True False 15313719.967130087 18156656.691666204 8406235.605272055 1.0 1.1856463831543411 0.5489349174018787 23.868321445170498 -6.828680344291437 1.333919640649943 1.0992873332765556 0.5322725881855144 0.9031946158737852 0.08318480021243808 0.1824387731874797 0.6353575540214431 0.04897203134655005 0.11269873909981756 1.4836096712313816e-07 6.828680344291437 -0.5670147450910412 EELEQTYHAK(ub)LENAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EELEQTYHAKLENAR 15 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 39838700.0 18169000.0 16122000.0 5547700.0 True False 23520128.664533354 15224796.527623026 4538075.52420898 1.0 0.6473092364745824 0.19294433244542866 24.48739261652767 -7.423178508434312 0.41636246843723973 1.0305365797266426 6.8207914001047095e-12 0.9989826086374147 0.01053701512364386 0.11384418067385714 0.0447389738782051 0.016382122926672255 0.061881949078677806 3.774170289934916e-08 7.423178508434312 -1.0305365797198218 down EELK(ub)SLQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EELKSLQAK 9 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77;A0A0D9SF91 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 12201200.0 4510500.0 5832900.0 1857800.0 True False 5913309.1797441365 4962654.0564661175 1665572.677275963 1.0 0.8392346663464749 0.28166507561981236 22.49553428028812 -6.948153348019637 0.5787627001010521 1.0066962050191037 0.08668383588165066 0.9990482804262699 0.00949598584390534 0.08423586431391024 0.03909743898541836 0.009962679989741088 0.04656137099339029 1.126799516548315e-07 6.948153348019637 -0.9200123691374531 down EELK(ub)SLQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EELKSLQAK 9 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77;A0A0D9SF91 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 13987500.0 4370200.0 5794800.0 3822500.0 True False 4231470.3931265315 8108693.859482786 2821272.577458061 1.0 1.9162827826124684 0.6667357479425705 22.01272764171407 -6.710168805354971 1.794664155626439 1.5632134942284766 0.6696639885140755 0.4658849859006804 0.38610600867532024 0.3747318126636293 2.352850025807119 0.17120319204691767 0.434837631346818 1.949086864478223e-07 6.710168805354971 -0.8935495057144011 EELK(ub)SLQAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EELKSLQAK 9 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77;A0A0D9SF91 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 28675600.0 11860000.0 7600000.0 9215600.0 True False 17992487.08214104 6243720.620928974 7394132.620659025 1.0 0.34701820778998127 0.41095667246571393 24.10089128676925 -10.105597920224893 5.115774621956536 1.0000165021648748 0.37898744013770286 0.9921123833562231 0.02610276890304012 4.913049647875768e-06 8.59014324911857e-07 0.025274567830899194 0.00842463243699891 7.841552957283993e-11 10.105597920224893 -0.6210290620271719 EELK(ub)SLQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EELKSLQAK 9 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77;A0A0D9SF91 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 11154700.0 4510500.0 3360300.0 3283900.0 True False 6178153.741679278 3211830.8349738787 2508310.4540434647 1.0 0.5198690368137188 0.4059967684393822 22.55874434181101 -13.999999999999906 0.2021434673128628 3.6910210703647515 0.3335854058534814 0.9994871471601832 0.005829336756010888 12.574114042497296 0.14255263391810782 13.39071790902094 0.07136604684380504 1.0000000000002168e-14 13.999999999999906 -3.35743566451127 EELK(ub)SLQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EELKSLQAK 9 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77;A0A0D9SF91 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 15893900.0 4370200.0 8445400.0 3078300.0 True False 3634014.9326863512 8399902.953919342 3721958.2975489357 1.0 2.311466273395286 1.0242000559963507 21.793132917148345 -6.6419156667568675 2.038346750846391 1.8564066031989759 1.0296497793553478 0.16175587588501472 0.5608762714201647 0.5285016437159643 4.199378202855975 0.22394049006338182 0.620784318218382 2.280784922009529e-07 6.6419156667568675 -0.826756823843628 EELK(ub)SLQAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EELKSLQAK 9 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77;A0A0D9SF91 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 32519500.0 11860000.0 12015000.0 8644500.0 True False 15353003.795550993 11346354.687966177 7071289.700060303 1.0 0.7390315822923287 0.4605802092037148 23.8720176088617 -6.970301822236493 0.2508812181079175 1.0874149955200842 0.10403227013805542 0.9999846388424546 0.000863235973897106 0.0762049753875021 0.00867943765233112 0.006173599490302442 0.026648655795905803 1.0707748886887488e-07 6.970301822236493 -0.9833827253820289 down EELKPDQK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EELKPDQKQR 10 2 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 1 20514400.0 7566500.0 8340900.0 4607000.0 True False 9919754.774090244 7096470.232573545 4130311.8334645047 1.0 0.7153876677585886 0.41637237285871337 23.24187302556366 -6.970501910960453 0.24590275034797968 1.0998070155872133 0.02324053547143437 0.9999860364708262 0.0008904156073188853 0.07614016865037497 0.008445349926448206 0.006858671908159604 0.02885370416218654 1.0702816735021315e-07 6.970501910960453 -1.0765664801157788 down EELKPDQK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EELKPDQKQR 10 2 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 1 16761300.0 6290500.0 6572900.0 3897900.0 True False 6090811.520745605 9197493.247220693 2876923.055506544 1.0 1.5100603943979511 0.47233821728149067 22.53820303045356 -6.7730543192345145 1.5627747582236664 1.2914132586179043 0.465816817674688 0.7421060454539627 0.21515273773708787 0.26151663426861144 1.2608845034638931 0.10849111483389319 0.25753583068434827 1.686342093534489e-07 6.7730543192345145 -0.8255964409432164 down EELKPDQK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EELKPDQKQR 10 2 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 1 18716700.0 7566500.0 7215000.0 3935200.0 True False 10364039.526974013 6896217.443185597 3005786.807988015 1.0 0.665398604978023 0.29002077811117866 23.30508308708655 -7.29552858109886 0.31942546633428415 1.0649483812000102 2.1113672046803164e-11 0.9998220122248205 0.003869040231023276 0.10330031612696487 0.022592871179090337 0.01260749746912778 0.049009245711549014 5.063740237440536e-08 7.29552858109886 -1.0649483811788965 down EELKPDQK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EELKPDQKQR 10 2 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 1 15660400.0 6290500.0 5033600.0 4336300.0 True False 5230829.466400506 5006482.997708626 5243000.281214128 1.0 0.9571107278237729 1.0023267466262855 22.318608305887835 -10.006578070562504 4.3306270667579945 1.0000007487573384 0.9797187372198314 0.21151357796057857 0.018459362395246606 239663404998.55124 54989501919.449844 2544420.0109910364 0.006318427260260576 9.849675650673145e-11 10.006578070562504 -0.020282011537506972 EELLFGGK(ub)LSPELLNTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EELLFGGKLSPELLNTGR 18 1 E9PB90;P52789 E9PB90 HK2 Hexokinase;Hexokinase-2 1 17738300.0 8887800.0 8850500.0 0.0 True False 8605661.653935745 12384550.804747766 0.0 1.0 1.439116630745501 0.0 23.036854688743013 -6.849393304837473 1.4075864685900215 1.2337573942815276 9.524940658201442e-22 0.8942992394945581 0.19578747198737553 0.17516939544174553 0.6973723685164858 0.11182819369001709 0.23641502752679147 1.414512192231823e-07 6.849393304837473 -1.2337573942815276 down EELLFGGK(ub)LSPELLNTGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EELLFGGKLSPELLNTGR 18 1 E9PB90;P52789 E9PB90 HK2 Hexokinase;Hexokinase-2 1 18941900.0 8887800.0 7304300.0 2749800.0 True False 7390599.496299885 7264950.286109965 3324770.4663613243 1.0 0.9829987796994241 0.44986478675050323 22.81725996417729 -6.9136918469823945 0.8702104846868146 1.014642717191317 0.3752337527005561 0.99224186295761 0.022497758665512096 0.1020273146193436 0.12589746654435285 0.018762241923296553 0.05321840742042324 1.2198548381491028e-07 6.9136918469823945 -0.639408964490761 down EELLFGGK(ub)LSPELLNTGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EELLFGGKLSPELLNTGR 18 1 E9PB90;P52789 E9PB90 HK2 Hexokinase;Hexokinase-2 1 26065000.0 14077000.0 0.0 11988000.0 True False 18222953.999154393 0.0 9806307.007267382 1.0 0.0 0.5381293838376823 24.11925350779129 -10.191219718394416 5.646496362508412 1.0000198200170152 0.26906469191880605 0.7109770274721205 0.21969040100023224 5.4815875949468765e-05 7.851539699138702e-06 0.21272007057069395 0.07090477203294238 6.438434496327333e-11 10.191219718394416 -0.7309551280982092 EELSNVLAAMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EELSNVLAAMR 11 0 Q9Y3U8 Q9Y3U8 RPL36 60S ribosomal protein L36 0 13153400.0 1249200.0 5696700.0 6207500.0 False True 1637713.2972700084 4846774.565562685 5565207.446544594 1.0 2.959476834951534 3.3981573306033086 20.64325138612617 -9.943564778906666 0.36931435737753165 2.51674664452934e-19 3.472345251665306 0.9987947387818132 0.03619583974160806 1.2900874478542108 0.16366490059118738 1.5493901586310659 0.12165533565532469 1.1387679117870734e-10 9.943564778906666 3.472345251665306 EELSNVLAAMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EELSNVLAAMR 11 0 Q9Y3U8 Q9Y3U8 RPL36 60S ribosomal protein L36 0 12124500.0 6226900.0 1787300.0 4110300.0 False True 6029230.467932739 2500978.210646373 3033689.123643128 1.0 0.41480885893285335 0.5031635695099409 22.523542446914938 -10.755568116075242 7.027738127422548 1.010361080822203 0.4589862142213971 0.9803888796502139 0.036070659547525384 0.005804561663349103 0.00020188832383175064 0.034620439131355644 0.011641755309523617 1.7556255149270427e-11 10.755568116075242 -0.5513748666008058 EELSNVLAAMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EELSNVLAAMR 11 0 Q9Y3U8 Q9Y3U8 RPL36 60S ribosomal protein L36 0 12629200.0 1249200.0 5506400.0 5873600.0 False True 1711062.9983606588 5263109.040770224 4486376.650589149 1.0 3.0759294343999737 2.62198215664033 20.706461447649062 -10.09178408148315 5.207029002952327 0.9999655008665964 2.848955795522924 0.9567470082565879 0.18532320011577896 7.422541621101668e-05 1.2945967741166374e-05 0.17944173300189573 0.05981280564146293 8.094982580122695e-11 10.09178408148315 1.8489902946563277 EEMQAGK(ub)HQEYEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEMQAGKHQEYEQK 14 1 O95628-5;O95628-3;O95628-2;O95628;O95628-8;O95628-4;O95628-7;O95628-9;O95628-10;O95628-6 O95628-5 CNOT4 CCR4-NOT transcription complex subunit 4 1 6462190.0 1344500.0 3835290.0 1282400.0 True False 1762652.520156523 3263079.6818433264 1149709.5496494228 1.0 1.8512325285493967 0.6522610307488903 20.749316666865834 -6.716055674592553 1.7738471985485444 1.5200642029495328 0.6545750491328797 0.4936733564977861 0.3583868154724419 0.3630452075016828 2.230346903558989 0.16057042279672917 0.40492220547667346 1.922845213031121e-07 6.716055674592553 -0.8654891538166531 EEMQAGK(ub)HQEYEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEMQAGKHQEYEQK 14 1 O95628-5;O95628-3;O95628-2;O95628;O95628-8;O95628-4;O95628-7;O95628-9;O95628-10;O95628-6 O95628-5 CNOT4 CCR4-NOT transcription complex subunit 4 1 4715100.0 2073900.0 1934600.0 706600.0 True False 2008065.1796954658 2707095.8688057195 521520.26245437854 1.0 1.3481115534388508 0.2597128159622139 20.937374667744965 -6.820659929646484 1.3690896031264095 1.1875039056527177 0.23562783469488574 0.8858799591993796 0.15331806146660937 0.19262481765276138 0.7092890220110172 0.08799868755583005 0.2027806590360463 1.5112630718032866e-07 6.820659929646484 -0.951876070957832 down EEMQAGK(ub)HQEYEQK ddPTM_RPMI8226_Bortezomib_8h_R1 2 EEMQAGKHQEYEQK 14 1 O95628-5;O95628-3;O95628-2;O95628;O95628-8;O95628-4;O95628-7;O95628-9;O95628-10;O95628-6 O95628-5 CNOT4 CCR4-NOT transcription complex subunit 4 1 25009430.0 10779600.0 8784300.0 5445530.0 True False 16353441.294321025 7216673.032950835 4369218.6086394135 1.0 0.4412938477638301 0.2671742619797516 23.963090921699028 -13.999999999999998 0.1632367900613626 3.7712070581959214 0.10197529268829118 0.9995282315196488 0.006789876868847438 12.032818335373289 0.12777993210805585 10.555980281086466 0.151199477646692 1.0000000000000041e-14 13.999999999999998 -3.66923176550763 EEMQAGK(ub)HQEYEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEMQAGKHQEYEQK 14 1 O95628-5;O95628-3;O95628-2;O95628;O95628-8;O95628-4;O95628-7;O95628-9;O95628-10;O95628-6 O95628-5 CNOT4 CCR4-NOT transcription complex subunit 4 1 5799490.0 1344500.0 2642090.0 1812900.0 True False 1841597.983746324 2525353.7275767485 1384730.357847497 1.0 1.3712839337711886 0.751917829009874 20.812526728388725 -6.744429717067799 1.6711680406235283 1.2197809447945287 0.751242577850267 0.6243705607677161 0.15599004785930126 0.30985918484458697 1.700888097380886 0.07380475023310519 0.18018877622156404 1.8012346090336064e-07 6.744429717067799 -0.46853836694426165 EEMQAGK(ub)HQEYEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 EEMQAGKHQEYEQK 14 1 O95628-5;O95628-3;O95628-2;O95628;O95628-8;O95628-4;O95628-7;O95628-9;O95628-10;O95628-6 O95628-5 CNOT4 CCR4-NOT transcription complex subunit 4 1 28643000.0 10779600.0 8186500.0 9676900.0 True False 13954404.697683075 7730914.078488141 7915803.49337885 1.0 0.554012460293039 0.5672619982630397 23.734217243791477 -10.114152990833963 5.499261993802166 1.0000059063377729 0.5606372292779188 0.9993184140839306 0.00540910122611294 3.9170220308407595e-07 6.309683586394982e-08 0.005237410106299179 0.0017457799138289613 7.688595430296262e-11 10.114152990833963 -0.43936867705985405 EEMQSNVEVVHTYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEMQSNVEVVHTYR 14 0 Q92597;Q92597-3;Q92597-2 Q92597 NDRG1 Protein NDRG1 0 6131600.0 1105800.0 2025300.0 3000500.0 False True 1449714.5085824323 1723133.1345575668 2690037.042828357 1.0 1.1886017035467833 1.8555633036043375 20.467337388457466 -6.947706912751114 0.5834744659371486 0.9921269631312775 2.085224583170168 0.9990088363940839 0.01155510194248836 0.0844197873409628 0.03987521058176865 0.012061697663882617 0.05576886359095913 1.1279584115082686e-07 6.947706912751114 1.0930976200388904 EEMQSNVEVVHTYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEMQSNVEVVHTYR 14 0 Q92597;Q92597-3;Q92597-2 Q92597 NDRG1 Protein NDRG1 0 15432300.0 1063900.0 10843000.0 3525400.0 False True 1614014.081508417 8907981.933254333 2828603.144762288 1.0 5.519147593141912 1.7525269309414864 20.622221734825704 -6.601391266032459 2.185985034482187 4.0364871171315535 1.7650182813474653 0.024496783237373032 1.9526254051319976 0.636656473674154 5.751926536174726 0.7410142786584173 2.17082266149344 2.5038524574817014e-07 6.601391266032459 -2.271468835784088 EEMVTGAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEMVTGAKR 9 1 Q86TM6-2;Q86TM6-3;Q86TM6 Q86TM6-2 SYVN1 E3 ubiquitin-protein ligase synoviolin 1 4315690.0 1538990.0 0.0 2776700.0 True False 2017630.7936003602 0.0 2489393.7199871712 1.0 0.0 1.2338202449542188 20.94423076905393 -6.691127392398755 1.8625984032721326 0.37371040118396504 1.2295892893020697 0.3755833725896083 0.4228359082514515 0.4142717074178977 2.7874393460257036 0.1815565941638639 0.47208239466977236 2.036444636036916e-07 6.691127392398755 0.8558788881181046 EEPGSDSGTTAVVALIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEPGSDSGTTAVVALIR 17 0 O15355 O15355 PPM1G Protein phosphatase 1G 0 17969000.0 4158100.0 6181400.0 7629500.0 False True 5451309.367097682 5259159.214908475 6840072.527331773 1.0 0.9647515598089218 1.254757722725518 22.378171366284537 -6.87650571040215 1.0990604597703346 0.979015615734294 1.2739845484790355 0.9707577747758838 0.022094674208184874 0.13077233322138104 0.2913501186174862 0.015531139426370234 0.03724788918464181 1.328906083641811e-07 6.87650571040215 0.29496893274474156 EEPGSDSGTTAVVALIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEPGSDSGTTAVVALIR 17 0 O15355 O15355 PPM1G Protein phosphatase 1G 0 12159600.0 3283300.0 2377100.0 6499200.0 False True 3179073.438687559 3326288.42641274 4796864.548179304 1.0 1.0463075139862 1.5088876179468285 21.600174913389427 -6.926211417182322 0.7772453278245529 0.9918910852895662 1.5953016066563455 0.9957402604855533 0.014995425529753859 0.09465252929648188 0.08766601530426774 0.013365516013073727 0.04276022269518497 1.1851916492428065e-07 6.926211417182322 0.6034105213667793 EEPGSDSGTTAVVALIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEPGSDSGTTAVVALIR 17 0 O15355 O15355 PPM1G Protein phosphatase 1G 0 17984900.0 4158100.0 6874500.0 6952300.0 False True 5695461.93842736 6570761.859068523 5310309.927113007 1.0 1.153683745077024 0.9323756324810588 22.44138142780743 -6.719927754148216 1.7594159056260763 1.0935063752690493 0.9327186104120789 0.5122205503981057 0.06467136278206746 0.355472377405569 2.1504339066216307 0.029185183331660453 0.07327636536325575 1.9057777219528003e-07 6.719927754148216 -0.16078776485697033 EEQAAAEK(ub)AVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEQAAAEKAVTK 12 1 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 1 2616460.0 864030.0 937170.0 815260.0 True False 1132751.6972784235 797347.8890600483 730904.7157261294 1.0 0.7039035041622763 0.645247071783003 20.111400221864578 -13.999999999999998 0.22761067408450825 2.848737696273068 0.6160716326604507 0.9995066244839629 0.0034487373840121596 13.217926802201408 0.151076977940245 11.028843046843441 0.030906899404549156 1.0000000000000041e-14 13.999999999999998 -2.2326660636126174 EEQAAAEK(ub)AVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEQAAAEKAVTK 12 1 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 1 2299620.0 579890.0 805160.0 914570.0 True False 561481.7093657376 1126664.5868539305 675016.6804881142 1.0 2.006591787516349 1.202206001065695 19.098879501092714 -10.252412594306128 4.783526877593676 0.9998395945157602 1.6043988942922278 0.42947165663828046 0.3283891221960579 0.0005619164584074366 8.781831339755164e-05 0.3180447716570053 0.10598713344449447 5.592260655509687e-11 10.252412594306128 0.6045592997764676 EEQAAAEK(ub)AVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEQAAAEKAVTK 12 1 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 1 5409260.0 1320600.0 931060.0 3157600.0 True False 2003446.7487921976 764905.0685950171 2533498.975974754 1.0 0.38179455932939044 1.2645701601513017 20.934052733061236 -6.7185384622097075 1.7654664984643866 0.6232857691706477 1.262998777090941 0.5052291935786837 0.2601910545349902 0.3581542595963063 2.18104279233861 0.11707945435336055 0.2943206342365813 1.9118839958596834e-07 6.7185384622097075 0.6397130079202933 EEQAAAEK(ub)AVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEQAAAEKAVTK 12 1 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 1 2915490.0 864030.0 1071800.0 979660.0 True False 1183485.24053279 1024444.3320313685 748284.4847310275 1.0 0.8656164833709094 0.6322719194995278 20.17461028338747 -6.962711744191762 0.3953656668935841 1.0135016380249957 0.47592993827918645 0.9998579248688195 0.001810872417673371 0.07874630819183442 0.017653646481123973 0.003005585066479537 0.019585327962606102 1.0896530926578604e-07 6.962711744191762 -0.5375716997458093 EEQAAAEK(ub)AVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEQAAAEKAVTK 12 1 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 1 2006000.0 579890.0 887040.0 539070.0 True False 482204.22848279023 882261.3394563454 651787.044621935 1.0 1.829642477902562 1.351682557145384 18.87928477652699 -10.236371799388207 4.806761795877223 0.9998738867983957 1.5906625175252196 0.6706481377264097 0.19512632056365317 0.0002637684897823009 4.190353961347987e-05 0.18897020799603964 0.06297674916186981 5.802674380232945e-11 10.236371799388207 0.5907886307268239 EEQAAAEK(ub)AVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEQAAAEKAVTK 12 1 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 1 6003200.0 1320600.0 1080000.0 3602600.0 True False 1709542.7329177607 1019897.0506036995 2946963.765797587 1.0 0.5965905566238704 1.723831589028406 20.705179055153685 -6.809942320880005 1.414899651080778 0.7801330367262234 1.7435028820823286 0.8596469957906893 0.17471216563355843 0.20687972670844634 0.8163071860418143 0.09709626113384191 0.2245965079308153 1.5490223325834951e-07 6.809942320880005 0.9633698453561053 EEQCILYLGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEQCILYLGPR 11 0 Q13451;Q13451-2 Q13451 FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5;Peptidyl-prolyl cis-trans isomerase FKBP5, N-terminally processed 0 4699550.0 1348900.0 828950.0 2521700.0 False True 1306079.9078505302 1159954.0579171414 1861191.1206215809 1.0 0.8881187521107539 1.4250208654420082 20.316811735069955 -6.852320809584155 1.223777563142032 0.9401542945035071 1.4474719933873934 0.943623053007635 0.05491530517293297 0.1549220843426811 0.4453017574278604 0.035090730465300354 0.0813348101050807 1.4050092724843963e-07 6.852320809584155 0.5073176988838863 EEQCILYLGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEQCILYLGPR 11 0 Q13451;Q13451-2 Q13451 FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5;Peptidyl-prolyl cis-trans isomerase FKBP5, N-terminally processed 0 6923100.0 1017300.0 2461900.0 3443900.0 False True 1393423.3014987973 2353125.117585392 2630521.7493469007 1.0 1.6887367356741618 1.8878123729648073 20.410202163375075 -11.012364654423408 0.23857396793714125 2.6995265807262838e-12 1.9954542433279725 0.9992543931460353 0.01038657842307543 3.0133694811924276 0.12817543963556022 1.7499430622617924 0.097078320214221 9.719308014737833e-12 11.012364654423408 1.9954542433252729 EEQELMEEINEDEPVK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEQELMEEINEDEPVKAK 18 1 O14776;O14776-2;G3V220 O14776 TCERG1 Transcription elongation regulator 1 1 11139200.0 2376400.0 2271300.0 6491500.0 True False 2300962.4827755964 3178241.9346730234 4791181.409174355 1.0 1.3812662998482208 2.082250990635391 21.133806029915792 -6.961656765595406 0.41141885822650853 0.9659986976433305 2.5235930546216405 0.9998267954029243 0.0058987331115341116 0.07911451842819507 0.01898309082488179 0.009030286720429787 0.05850037946612909 1.0923032715415245e-07 6.961656765595406 1.55759435697831 up EEQELMEEINEDEPVK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEQELMEEINEDEPVKAK 18 1 O14776;O14776-2;G3V220 O14776 TCERG1 Transcription elongation regulator 1 1 8262800.0 2376400.0 3027700.0 2858700.0 True False 1976081.8923701122 3011389.1791486028 3456440.952864615 1.0 1.523919221554499 1.7491385181000572 20.91421130535007 -10.97651888543678 0.16310652133271764 1.4713959821927148e-24 2.0107812142935977 0.9995752987352282 0.0064675680199148605 3.135352287697688 0.09353705411172254 1.3681920765303552 0.18763437344334188 1.0555556010393179e-11 10.97651888543678 2.0107812142935977 EEQFK(ub)QVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEQFKQVFK 9 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 14900000.0 4622000.0 4672600.0 5605400.0 True False 6059486.759511665 3975466.2936521475 5025406.978793562 1.0 0.6560731051044545 0.829345318876241 22.53076417146059 -10.147024125403052 5.13899212368948 1.0000106411328802 0.7427092119900686 0.7461850565726837 0.07073808505819319 8.62461580332971e-06 1.4314347045239975e-06 0.0684946885288364 0.022830618780942464 7.128134316749706e-11 10.147024125403052 -0.2573014291428116 EEQFK(ub)QVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEQFKQVFK 9 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 21626200.0 6011100.0 5661000.0 9954100.0 True False 5820280.920809788 7921466.82172501 7346822.593400987 1.0 1.3610110799639685 1.2622797238417158 22.47265735704164 -10.136769566291587 4.401790931600616 0.9999534866170043 1.3116454019183652 0.9299947623366227 0.04030690743701364 28159234.009349026 1.3855284993085253 14104.680530938895 0.013798126503584212 7.298446581651305e-11 10.136769566291587 0.31169191530136087 EEQFK(ub)QVFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEQFKQVFK 9 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 97352000.0 28083000.0 36607000.0 32662000.0 True False 42603964.142307505 30074194.83820354 26206341.383736856 1.0 0.7059013273447626 0.6151150934265498 25.3444843383803 -13.999999999999998 0.16460881700630778 2.463391213260771 0.5302555182369526 0.9995250108181134 0.0035802163050120744 12.043646346278715 0.12835478888484664 5.626162101520878 0.07781451585685742 1.0000000000000041e-14 13.999999999999998 -1.9331356950238183 EEQFK(ub)QVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEQFKQVFK 9 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 18346800.0 4622000.0 5543100.0 8181700.0 True False 6330878.304853473 5298187.513419553 6249350.96740079 1.0 0.8368803281778101 0.9871222706349954 22.59397423298348 -10.423902894328531 6.890487292641536 1.0000094381412539 0.9120012994108109 0.3138528791066235 0.06133601616411596 8.894075687038075e-06 7.43649127990206e-07 0.059394710624415675 0.019796114093860843 3.7678803713732417e-11 10.423902894328531 -0.088008138730443 EEQFK(ub)QVFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEQFKQVFK 9 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 19639800.0 6011100.0 8473700.0 5155000.0 True False 4998495.986881827 8428050.496202232 6232886.665973019 1.0 1.6861172877443555 1.2469524197540134 22.253062632475917 -10.265472718229633 4.738248785147073 0.9998456484148529 1.4665348537502072 0.6007515957738019 0.17928830659235748 0.00029243212580134343 4.5332515045318486e-05 0.17365208550270025 0.057865052132996135 5.426593393570806e-11 10.265472718229633 0.4666892053353543 EEQFK(ub)QVFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEQFKQVFK 9 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 86269000.0 28083000.0 30758000.0 27428000.0 True False 36353997.09868959 29046290.261544995 22436385.43504585 1.0 0.7989847769061958 0.6171641972171084 25.11561066047275 -6.972318954977802 0.19500137414836918 1.11545686937695 0.2956988956900492 0.9999952698728514 0.00034001071832770485 0.0755572089162489 0.006258111327191428 0.006153298664146139 0.019553783186035272 1.0658130782413957e-07 6.972318954977802 -0.8197579736869007 EEQHQLAVTAYLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEQHQLAVTAYLK 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 16621800.0 4240200.0 6512600.0 5869000.0 False True 5558943.262155213 5540945.465915971 5261732.179423313 1.0 0.9967623709416555 0.9465346076195296 22.406379226491453 -6.920019708356278 0.8245851494668931 1.001107452766303 0.9384313759043187 0.9941862495335705 0.0018662684808842412 0.09816013555297395 0.10555562042537345 0.0016081481678208412 0.004818042743773173 1.2022098768940706e-07 6.920019708356278 -0.0626760768619844 EEQHQLAVTAYLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEQHQLAVTAYLK 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 17764900.0 3959700.0 4465000.0 9340200.0 False True 3834001.4909301954 6247897.784667397 6893721.420006217 1.0 1.629602335692245 1.7980487061140085 21.870419467351933 -11.225392994893696 0.24339295441657127 1.2125985680346377e-11 1.8830042948011665 0.9992739312078757 0.009254634135856529 3.40695273937622 0.13349159981799677 1.931446783365401 0.08010822718491417 5.951233701690705e-12 11.225392994893696 1.8830042947890404 EEQHQLAVTAYLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEQHQLAVTAYLK 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 61395200.0 14988100.0 25993000.0 20414100.0 False True 22738043.476883475 21354346.065764077 16379244.187182108 1.0 0.9391461533387371 0.7203453632162323 24.43860478530036 -6.947326400241019 0.5874677644045159 1.0025487473122783 0.6459808930450915 0.998974379833975 0.0038457548361476006 0.0845775323799383 0.04054557920928607 0.003997514102175776 0.018316299563193684 1.1289471193660086e-07 6.947326400241019 -0.35656785426718673 EEQHQLAVTAYLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEQHQLAVTAYLK 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 10272600.0 4240200.0 6032400.0 0.0 False True 5807916.527096436 5765868.6215208275 0.0 1.0 0.9927602427859565 0.0 22.469589288014344 -7.029110790632862 1.079350801327984 1.019723108697293 4.345526677609921e-18 0.9864076729654365 0.05476136953136089 0.08716660680616838 0.1968416212961403 0.04271436640507417 0.077171258416431 9.351670780491196e-08 7.029110790632862 -1.019723108697293 down EEQHQLAVTAYLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEQHQLAVTAYLK 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 10296800.0 3959700.0 3507500.0 2829600.0 False True 3292665.9944529207 3488604.4013157585 3421256.2774078087 1.0 1.0595075258750601 1.039053546023654 21.65082474278621 -9.964259261185406 5.048140372794419 0.9999997089080331 1.04928053595006 0.885581836041019 0.008350302309960828 2.736230142043325e-08 5.60853623065584e-09 0.00808519327450936 0.0026950484815063892 1.0857772526390974e-10 9.964259261185406 0.049280827042026965 EEQHQLAVTAYLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEQHQLAVTAYLK 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 39340400.0 14988100.0 19423900.0 4928400.0 False True 19402390.90962038 18342942.890019655 4031481.7696543685 1.0 0.9453960068872022 0.2077827309239203 24.20973110739281 -6.921757080319053 0.8115914822323715 1.015267444057148 0.0838932566206695 0.9946551578707962 0.026412094772683466 0.09714903837255229 0.10033875387453722 0.02297101742806064 0.07000834673335313 1.197410107272785e-07 6.921757080319053 -0.9313741874364786 down EEQHQLAVTAYLK(ub)NSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEQHQLAVTAYLKNSR 16 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 22339500.0 3833900.0 10025000.0 8480600.0 True False 5816306.595634101 8235960.424317503 6804405.692820977 1.0 1.4160120841118777 1.1698842866929633 22.47167188953466 -10.235184342584215 4.730262349459756 0.9999293704494886 1.2929481854032732 0.6538423062818486 0.10048125253510531 7.486675089253962e-05 1.2104834245169266e-05 0.09731395376315703 0.032430184805757115 5.818561880588765e-11 10.235184342584215 0.29301881495378457 EEQHQLAVTAYLK(ub)NSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEQHQLAVTAYLKNSR 16 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 14857000.0 3833900.0 5306600.0 5716500.0 True False 4963059.127467358 5011283.045123702 4676155.656243243 1.0 1.0097165712553082 0.942192211727584 22.24279821162711 -6.870396858613933 1.132052080038356 1.0055082865546432 0.938208702539851 0.9650746442391566 0.00557027899450804 0.13647195101762533 0.3266447187196386 0.0038179114541460855 0.009044957778181255 1.3477307623687808e-07 6.870396858613933 -0.06729958401479219 EEQK(ub)LIATSNKPAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEQKLIATSNKPAVK 15 2 Q9H3F6;F5GWA4;Q9H3F6-2;F5H497 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 6112800.0 1847000.0 1901900.0 2363900.0 True False 1788367.9959966838 2661338.588277478 1744723.6745201037 1.0 1.4881381204735071 0.9755954470364716 20.77021220258643 -8.796177708024715 18.6343301002075 1.000009670626216 1.2318667837549893 0.21437380116710236 0.2092446702949389 0.0 0.0 0.20260028080008133 0.06753342693336042 1.5989036427987009e-09 8.796177708024715 0.23185711312877322 EEQK(ub)LIATSNKPAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEQKLIATSNKPAVK 15 2 Q9H3F6;F5GWA4;Q9H3F6-2;F5H497 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 5688750.0 1847000.0 2936200.0 905550.0 True False 1535862.3359735694 2920382.1078099334 1094896.3182098675 1.0 1.9014608532337822 0.712887016345656 20.550617478020705 -6.703892744571323 1.8169252623543781 1.557617991064274 0.7161443493292703 0.4361092628103197 0.380253130289418 0.3874737391182705 2.489411435156938 0.1667922975395164 0.4269064882568804 1.977457942221414e-07 6.703892744571323 -0.8414736417350037 EEQK(ub)LIATSNKPAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEQKLIATSNKPAVK 15 2 Q9H3F6;F5GWA4;Q9H3F6-2;F5H497 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 13467500.0 4121100.0 3266700.0 6079700.0 True False 5334845.189025727 3084905.273339913 4973256.982989945 1.0 0.5782558188728419 0.9322214247604406 22.34701497565683 -10.047990190064787 7.14222633253356 1.0000000388394752 0.7552386218166413 0.38932512888301096 0.14450585348661785 8.93275204577414e-08 1.182259302582931e-08 0.139917212887485 0.04663906366526331 8.953849904658887e-11 10.047990190064787 -0.24476141702283394 EEQMDGTVTLK(ub)DLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEQMDGTVTLKDLR 14 1 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 1 15013400.0 1688500.0 1602900.0 11722000.0 True False 1634899.4917381715 2242946.3290130734 8651656.547537833 1.0 1.3719169529060447 5.291858362705634 20.640770515611468 -6.925351854126849 0.7840005837912017 0.9290167982593867 6.008976679132833 0.9955432162726733 0.129611949590901 0.09512443014647591 0.09003612154509634 0.11496615276809073 0.3641723868266409 1.1875397237037415e-07 6.925351854126849 5.079959880873447 up EEQMDGTVTLK(ub)DLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEQMDGTVTLKDLR 14 1 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 1 11259700.0 1688500.0 2478700.0 7092500.0 True False 1404062.5632330126 2465346.7511165696 8575508.957985193 1.0 1.7558667367640872 6.10764020247012 20.421175791045744 -6.936714746002714 0.6894471778008673 0.9472826901091925 7.1758267826713675 0.9977011887745334 0.10791945656074595 0.08929781908943922 0.06167702830507342 0.10260017998578011 0.38028482056212465 1.1568718511234228e-07 6.936714746002714 6.228544092562175 EERPDIK(ub)LSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EERPDIKLSLK 11 2 H7BYP4;U5Y3L1;Q9H930-2;Q9H930;Q9H930-1;Q9H930-3 H7BYP4 SP140L Nuclear body protein SP140-like protein 1 8870200.0 1934600.0 3255300.0 3680300.0 True False 2536279.3346930468 2769621.9290600163 3299497.8599304194 1.0 1.0920019302192556 1.3009205314247223 21.274282215662517 -6.957487797114036 0.4695037857641369 0.9944551909150314 1.4070247216497116 0.9996653682060855 0.00230313261972835 0.0806110770006208 0.024542177788357034 0.0028859539887348333 0.017243812543134028 1.1028392211928077e-07 6.957487797114036 0.41256953073468017 EERPDIK(ub)LSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EERPDIKLSLK 11 2 H7BYP4;U5Y3L1;Q9H930-2;Q9H930;Q9H930-1;Q9H930-3 H7BYP4 SP140L Nuclear body protein SP140-like protein 1 10385600.0 2344000.0 2165000.0 5876600.0 True False 2269591.0030407286 3029495.790325848 4337342.165778949 1.0 1.334820144363906 1.9110677474346305 21.114000906026238 -6.962872335022126 0.3928612619862973 0.9657179052850973 2.300970396750279 0.9998623466454853 0.004414609810357939 0.07869057101187182 0.017453502528092666 0.007429396223286098 0.04841509350799913 1.0892502417049442e-07 6.962872335022126 1.3352524914651815 EERPDIK(ub)LSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EERPDIKLSLK 11 2 H7BYP4;U5Y3L1;Q9H930-2;Q9H930;Q9H930-1;Q9H930-3 H7BYP4 SP140L Nuclear body protein SP140-like protein 1 21716400.0 4410300.0 7671000.0 9635100.0 True False 6690747.5361186005 6302050.116203434 7730718.26178565 1.0 0.9419052328881242 1.155434160391344 22.673735976962526 -6.834231404548006 1.308980079844446 0.9690376388060943 1.1616894348014954 0.9140597286599523 0.026425490112449195 0.1756480196225714 0.5870989042001254 0.01584360450143981 0.03646196842174353 1.4647671630619574e-07 6.834231404548006 0.19265179599540116 EERPDIK(ub)LSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EERPDIKLSLK 11 2 H7BYP4;U5Y3L1;Q9H930-2;Q9H930;Q9H930-1;Q9H930-3 H7BYP4 SP140L Nuclear body protein SP140-like protein 1 6130700.0 1934600.0 1344100.0 2852000.0 True False 2649873.9005992045 1284713.2176556827 2178416.3387837512 1.0 0.48482051065342247 0.8220830199848964 21.337492277185408 -9.933074877798902 5.408690233873678 1.0000004937526952 0.6534517653210755 0.5846769754610206 0.1376868428770953 9.75568472797555e-07 1.92459275889745e-07 0.1333149388204558 0.04443823745385328 1.1666084618350588e-10 9.933074877798902 -0.34654872843161966 EERPDIK(ub)LSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EERPDIKLSLK 11 2 H7BYP4;U5Y3L1;Q9H930-2;Q9H930;Q9H930-1;Q9H930-3 H7BYP4 SP140L Nuclear body protein SP140-like protein 1 19512700.0 4410300.0 8308400.0 6794000.0 True False 5709220.290009992 7846030.2363294205 5557561.712326877 1.0 1.3742735150819847 0.9734362014461961 22.444862299054975 -6.661634100543524 1.9675584272763706 1.2405959391304031 0.9751178833286055 0.24242126304447997 0.15929612561525583 0.48055407307783493 3.5781264350973108 0.06537860205389436 0.17656930711139274 2.179545297824966e-07 6.661634100543524 -0.2654780558017976 EESAASGGAAYTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EESAASGGAAYTK 13 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 6035310.0 1957500.0 792110.0 3285700.0 False True 1895360.2339813265 1108403.6537990796 2425076.6011128696 1.0 0.584798411366269 1.279480574528484 20.854040643782394 -6.744858908750273 1.6691726486015463 0.7543493632204701 1.28031152481577 0.6264074532798171 0.1744435960422785 0.3091114152543712 1.6928090691064392 0.08262191473714735 0.20165471125292964 1.7994554175527113e-07 6.744858908750273 0.5259621615952998 EESDDEAAVEEEEEEKKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EESDDEAAVEEEEEEKKPK 19 2 P14625 P14625 HSP90B1 Endoplasmin 0 16446100.0 3626900.0 1410200.0 11409000.0 False True 3511766.0447646827 1973300.2140958472 8420640.637336558 1.0 0.561911069513765 2.3978364532255765 21.74376530448771 -6.843745570525282 1.2649595154897695 0.7669441535600147 2.462810018526199 0.9306919520665986 0.20611140458099492 0.1644710191522405 0.5096022928622405 0.127682377747345 0.2945065601838847 1.4330271859541417e-07 6.843745570525282 1.6958658649661844 up EESEK(ub)EQTAVETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EESEKEQTAVETK 13 1 Q9UHC7-2;Q9UHC7;Q9UHC7-3;Q9UHC7-4;C9J031;C9IY57 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 3405380.0 932670.0 896910.0 1575800.0 True False 1222739.4019891268 763094.5241277979 1412751.3321409537 1.0 0.6240859850319797 1.1553985500448578 20.221685529592605 -6.716617296107437 1.7712791897994498 0.7704784763061696 1.1544288714584081 0.49659255468186314 0.15825515365335063 0.3619360698631664 2.2173011493314028 0.07098959991367106 0.17893741677641423 1.9203602326162936e-07 6.716617296107437 0.3839503951522385 EESEK(ub)EQTAVETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EESEKEQTAVETK 13 1 Q9UHC7-2;Q9UHC7;Q9UHC7-3;Q9UHC7-4;C9J031;C9IY57 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 6218640.0 1123100.0 1415600.0 3679940.0 True False 1087447.8052538587 1980856.4622564767 2716053.318166387 1.0 1.8215646329747814 2.497640167228384 20.052514726231728 -6.9733563124409965 0.15869822974767425 0.30341066631918073 4.033711552626392 0.9999981326823542 0.0008367825931643843 0.07522787159072485 0.0048923962970084086 0.03168519903145523 0.08152258009565598 1.0632703110803858e-07 6.9733563124409965 3.7303008863072113 EESEK(ub)EQTAVETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EESEKEQTAVETK 13 1 Q9UHC7-2;Q9UHC7;Q9UHC7-3;Q9UHC7-4;C9J031;C9IY57 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 5634240.0 1363600.0 3426260.0 844380.0 True False 2068680.89251328 2814817.1335084345 677487.9228950993 1.0 1.3606821350240537 0.32749754945143145 20.980279686588467 -6.812378918381715 1.4043324235555668 1.1960236481779665 0.3083902637090288 0.8659949685592789 0.156732038345333 0.20357042670389613 0.7907741936751427 0.08774174574490493 0.20277178310087934 1.540355918552711e-07 6.812378918381715 -0.8876333844689377 down EESEK(ub)EQTAVETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EESEKEQTAVETK 13 1 Q9UHC7-2;Q9UHC7;Q9UHC7-3;Q9UHC7-4;C9J031;C9IY57 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 4647720.0 932670.0 956920.0 2758130.0 True False 1277503.3034590408 914640.1102887269 2106716.4994704193 1.0 0.715959096005619 1.6490888859278512 20.284895591115497 -6.825023765883923 1.3499094879429314 0.8476288476320425 1.6717553590149619 0.8955665445297876 0.1262090880467606 0.18703389856712854 0.6682687315855564 0.07344129945700616 0.1690946094653885 1.4961537798757223e-07 6.825023765883923 0.8241265113829194 EESEK(ub)EQTAVETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EESEKEQTAVETK 13 1 Q9UHC7-2;Q9UHC7;Q9UHC7-3;Q9UHC7-4;C9J031;C9IY57 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 4848410.0 1123100.0 1661100.0 2064210.0 True False 933907.4117660623 1652151.3245974653 2495826.7671713247 1.0 1.7690740043203752 2.6724563224652007 19.832920001666004 -6.969001725730069 0.2810064955547867 0.8033769133049327 3.665719406963552 0.9999735159948536 0.0035175210377616384 0.07662796011206631 0.010184406428855184 0.016590390807351238 0.0828143466414312 1.0739851447020785e-07 6.969001725730069 2.8623424936586193 EESEKEQTAVETK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EESEKEQTAVETKK 14 2 Q9UHC7-2;Q9UHC7;Q9UHC7-3;Q9UHC7-4;C9J031;C9IY57 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 8845600.0 1924300.0 3415800.0 3505500.0 True False 1600140.7109442016 3397398.4074167837 4238483.842399303 1.0 2.1231872823309814 2.648819452820673 20.609767345721462 -9.519799568277485 0.2147919992808625 3.3831091569458296e-19 3.090901246602483 0.9993664280293325 0.017310124175404378 0.9433641394635351 0.08628232146672989 0.8939953323387474 0.2783511147383307 3.0213457832946595e-10 9.519799568277485 3.090901246602483 EESGK(ub)PGAHVTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EESGKPGAHVTVK 13 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 92364000.0 25641000.0 37529000.0 29194000.0 True False 33615599.30779725 31929819.48689625 26173284.928622287 1.0 0.9498512638294692 0.7786053340584442 25.002627534759124 -6.948509510291445 0.5749774979573566 1.002087854580797 0.717971457431425 0.999079036705115 0.0028764329269162117 0.0840898977204842 0.038482832808076205 0.003030383790704486 0.014286057597936235 1.1258758139089682e-07 6.948509510291445 -0.284116397149372 EESGK(ub)PGAHVTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EESGKPGAHVTVK 13 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 199408000.0 46554000.0 39574000.0 113280000.0 True False 70625821.55328776 32511710.506926756 90890158.34761223 1.0 0.4603374487105457 1.2869253248832633 26.073692408842092 -6.730526637951257 1.7212412977335787 0.6754263230472695 1.2864875489650505 0.5617410683365365 0.22685191622393017 0.33524938736565574 1.9460646267115798 0.10443106597185 0.258991023705269 1.8598304848834334e-07 6.730526637951257 0.611061225917781 EESGK(ub)PGAHVTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EESGKPGAHVTVK 13 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 96647000.0 25641000.0 37495000.0 33511000.0 True False 35121170.62197062 35838346.92061594 25596391.980709113 1.0 1.0204200567903816 0.7288023584469271 25.065837596282016 -6.890103170556844 1.0217973537519214 1.015630286228433 0.7036721258160288 0.980963341106923 0.01833922056616219 0.1190584670234467 0.22137139997561792 0.013673873657197235 0.03410106226854368 1.2879435527834633e-07 6.890103170556844 -0.3119581604124042 EESGK(ub)PGAHVTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EESGKPGAHVTVK 13 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 106795000.0 39958000.0 50726000.0 16111000.0 True False 33226847.439540867 50452728.96967737 19479735.611152556 1.0 1.5184326187273856 0.5862649367081131 24.985846080952005 -6.755754175820292 1.6284719726152113 1.3027179633121937 0.5835576921729646 0.6733976316034793 0.21794116423988572 0.2901054220538353 1.5152522172890204 0.1056467785379683 0.25495964976279767 1.754873533753873e-07 6.755754175820292 -0.7191602711392291 EESGK(ub)PGAHVTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EESGKPGAHVTVK 13 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 173879000.0 46554000.0 37152000.0 90173000.0 True False 60265070.71653287 35084458.54076732 73762439.25311325 1.0 0.582169042923605 1.223966692083837 25.84481873093454 -6.730984461895253 1.7194384390244102 0.7488326821437875 1.2236692841394103 0.5639318933065123 0.17563279000424922 0.33438639865952924 1.9371715390859354 0.0809281036173397 0.20060966234982722 1.857870924452527e-07 6.730984461895253 0.47483660199562283 EESGKPGAHVTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EESGKPGAHVTVK 13 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 240443000.0 36699000.0 122980000.0 80764000.0 False True 48112744.3936216 104631863.37228546 72407316.02299273 1.0 2.174722408604833 1.5049508593941672 25.519915758583746 -10.118402184426 4.847675653361917 0.9999553000753811 1.8398366339954741 0.6770447243559901 0.27343308998503 0.00013216108341773984 2.403518961506533e-05 0.2647644793893301 0.08825015031521254 7.613736028692109e-11 10.118402184426 0.839881333920093 EESGKPGAHVTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EESGKPGAHVTVK 13 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 79807000.0 50411000.0 29396000.0 0.0 False True 48810730.39858634 41133976.098114915 0.0 1.0 0.8427240437136798 0.0 25.540695004440046 -7.188104067774139 0.9027424807412995 0.9913824718851479 2.103936570029486e-19 0.9894531507224925 0.045089952814208974 0.09154566716829331 0.14163356779435568 0.03793530905504213 0.06658702245915633 6.484790232043022e-08 7.188104067774139 -0.9913824718851479 down EESGKPGAHVTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EESGKPGAHVTVK 13 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 231170000.0 36699000.0 91061000.0 103410000.0 False True 50267612.053184345 87037623.9215416 78986687.79580215 1.0 1.7314851524964763 1.5713236529364538 25.583125820106638 -10.05591126556502 4.486151158741115 0.9999645812016373 1.6514044026672199 0.9566270654522234 0.06538565856817366 15105130.01779724 0.47814794532978244 5912.051123518229 0.022383250058279396 8.792021358187806e-11 10.05591126556502 0.6514398214655825 EESLEK(ub)EPEYVPWTATSGPGGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EESLEKEPEYVPWTATSGPGGIR 23 1 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 13641300.0 3887500.0 4025600.0 5728200.0 True False 5096550.14660355 3424996.171665902 5135500.812774344 1.0 0.6720224609088548 1.0076425552678516 22.281089586898286 -10.914837425737264 11.049224770498926 1.0183482204680405 0.8398325080883534 0.23293047172490455 0.13701632976738087 0.056706891626606915 0.00043707106453888544 0.12147689506426236 0.0442218302789608 1.2166413542433468e-11 10.914837425737264 -0.1785157123796871 EESLEK(ub)EPEYVPWTATSGPGGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EESLEKEPEYVPWTATSGPGGIR 23 1 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 14619000.0 6019000.0 2889300.0 5710700.0 True False 5827930.139634025 4043012.5575004523 4214896.352672269 1.0 0.69373044299298 0.7232235547931517 22.47455215300532 -9.927980523435437 5.659128998174743 1.0000002500209872 0.7084769991504286 0.9923820902532041 0.012040512474341526 3.798834554365911e-08 7.183196306178321e-09 0.011658186148253024 0.0038860586908645613 1.180373570025776e-10 9.927980523435437 -0.29152325087055864 EESLEK(ub)EPEYVPWTATSGPGGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EESLEKEPEYVPWTATSGPGGIR 23 1 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 12549000.0 3887500.0 3576500.0 5085000.0 True False 5324813.8057373185 3418478.4040960874 3884027.728862339 1.0 0.6419902232849504 0.7294203836155589 22.344299648421178 -10.345524402299231 9.81445161785126 1.0000001185817773 0.6857053034502547 0.9451459621120888 0.035693213489952406 9.261234647929307e-08 6.191668478024766e-09 0.03455981822908789 0.01151993511826763 4.5131066621761925e-11 10.345524402299231 -0.3142948151315226 EESLEK(ub)EPEYVPWTATSGPGGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EESLEKEPEYVPWTATSGPGGIR 23 1 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 52032000.0 13170000.0 18999000.0 19863000.0 True False 17048824.619511493 17941688.94853676 16248137.811590912 1.0 1.052371019642224 0.9530356593026221 24.02316894457221 -6.763428654995651 1.5993128437159803 1.030289180820747 0.9526065186928309 0.7049281221015846 0.02203974019829055 0.27718094821334543 1.3979947092079472 0.01086875783412142 0.026034321168059624 1.7241353051656097e-07 6.763428654995651 -0.07768266212791619 EESPLLIGQQSTVSDVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EESPLLIGQQSTVSDVPR 18 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 17652600.0 2826800.0 7801000.0 7024800.0 False True 3705962.174770138 6637121.208059842 6297941.082639779 1.0 1.790930639617634 1.6994078151999508 21.821416725770295 -10.16543229742074 4.436886725375898 0.9998543053914409 1.7451692274323858 0.9888127246644657 0.03736403669990034 26177093.849609014 11.210910141829725 39499.09607687981 0.0127907035734847 6.832312192414606e-11 10.16543229742074 0.7453149220409448 EESPLLIGQQSTVSDVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EESPLLIGQQSTVSDVPR 18 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 15970300.0 2826800.0 6107500.0 7036000.0 False True 3871944.35139762 5837650.455198336 5374241.710968619 1.0 1.507679327336193 1.387995596844962 21.884626787293186 -9.971813977102661 4.690228502472822 0.9999934067470814 1.4478374619335552 0.9491572718831021 0.04886067847268369 16789797.36258263 0.619799424963657 1222.2265722418952 0.01672630984355134 1.0670530779916429e-10 9.971813977102661 0.44784405518647386 EETAK(ub)LIEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EETAKLIEK 9 1 P13639 P13639 EEF2 Elongation factor 2 1 7805000.0 3214700.0 2424800.0 2165500.0 True False 4214502.83119908 2063029.291796373 1941434.8329427803 1.0 0.48950715527444905 0.4606557192394666 22.006931021305697 -13.985073912401116 0.40913188128696587 9.9994048674721 0.4593011206024894 0.9998500689016716 0.0030333476961161023 27.788153335970982 0.21177001347802799 222.63990201513175 0.007204571695496021 1.0349660112456378e-14 13.985073912401116 -9.54010374686961 EETAK(ub)LIEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EETAKLIEK 9 1 P13639 P13639 EEF2 Elongation factor 2 1 8807700.0 3214700.0 2237500.0 3355500.0 True False 4403261.464000964 2138639.851576958 2563000.008691753 1.0 0.48569449465163306 0.5820685484261291 22.070141082828588 -9.88249206017072 5.495135823512723 1.0000003370065988 0.5338815215365136 0.9689341563269734 0.03934454270711779 1.6244405345018576e-07 3.2953620591351304e-08 0.038095217478215454 0.012698396554486416 1.3107140047941956e-10 9.88249206017072 -0.46611881547008527 EETAK(ub)LIEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EETAKLIEK 9 1 P13639 P13639 EEF2 Elongation factor 2 1 34198800.0 7652800.0 10975000.0 15571000.0 True False 9906700.459240526 10364231.602199642 12737237.77195197 1.0 1.0461840089787262 1.2857194809066066 23.239973200527277 -6.938991366040667 0.6688803872222158 0.9972587432838563 1.3484421566120646 0.9980287966784358 0.005560044195853635 0.08822975388941581 0.056727608843439706 0.00537179444568854 0.020709630892235986 1.150823267573889e-07 6.938991366040667 0.35118341332820824 EETEELK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 EETEELKR 8 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 40218000.0 13041000.0 16047000.0 11130000.0 True False 17096877.289223626 13652850.15071609 9978374.366498789 1.0 0.7985581179389789 0.5836372454277532 24.0272295079922 -6.970302370780514 0.2508571331113713 1.0674906577707635 0.3084030718347734 0.9999846453896734 0.000666154832156719 0.07620470479073493 0.00867829773952288 0.004765827384270417 0.020569404477890345 1.0707735362267295e-07 6.970302370780514 -0.75908758593599 EETEELK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 EETEELKR 8 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 42182000.0 14788000.0 14818000.0 12576000.0 True False 14318563.034541955 20734904.674849153 9281968.328086993 1.0 1.4481135170357864 0.6482471953152887 23.771383379791235 -6.754667166537726 1.632440964469097 1.2620064552013197 0.6460603270677598 0.6688662976675783 0.18836120096540038 0.29196930824106526 1.532126352790124 0.09109591393116541 0.22009502735176265 1.7592713632085976e-07 6.754667166537726 -0.6159461281335599 EETEELK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 EETEELKR 8 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 25034700.0 4114900.0 5004800.0 15915000.0 True False 6242604.13948585 4111654.337319125 12769393.2742077 1.0 0.6586440923447321 2.0455234688739057 22.57371655280111 -6.841602669051468 1.2749516402479075 0.8184306007352354 2.092599677457121 0.9271728580237132 0.1592248884110007 0.16693421604774228 0.5264125564141158 0.0979015382667947 0.22564972477123593 1.4401155206043188e-07 6.841602669051468 1.2741690767218854 up EETEELK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EETEELKR 8 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 39782000.0 13041000.0 10405000.0 16336000.0 True False 17862610.119773716 9945272.695266273 12477773.250480853 1.0 0.5567648080868631 0.6985414318967916 24.09043956951509 -10.908702309906428 11.21137183797069 1.0352675562375644 0.6276531199918274 0.9019276074734867 0.057880064298141534 0.03055237930262086 0.00024879713085502407 0.033557876318804074 0.018680710425343052 1.2339503630411368e-11 10.908702309906428 -0.407614436245737 EETEELK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EETEELKR 8 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 41599000.0 14788000.0 15238000.0 11573000.0 True False 12296877.219478708 15155909.869493807 13992860.792493828 1.0 1.2325007072109564 1.1379198590621544 23.55178865522551 -10.169186958114233 4.5870003390195455 0.9999713779149381 1.185210283138945 0.8364100143143068 0.038612469575854506 1.1304491432564207e-05 2.0474625036448283e-06 0.037392136886967006 0.012462120967406252 6.773498545543777e-11 10.169186958114233 0.185238905224007 EETEELK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EETEELKR 8 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 21783200.0 4114900.0 2755300.0 14913000.0 True False 5326819.166805462 2601965.1328966427 12198987.020301832 1.0 0.4884650767030004 2.290107217515639 22.34484287489356 -6.830842477925129 1.3241264878112113 0.726827780022403 2.3394337131208567 0.9075553951749015 0.23048733562405413 0.17977102915223436 0.6161386968535694 0.13665876900240517 0.31448683433976937 1.4762418808952976e-07 6.830842477925129 1.6126059330984537 up EETK(ub)EDAEEKQ ddPTM_RPMI8226_Bortezomib_1h_R1 1 EETKEDAEEKQ 11 2 P43487-2;P43487;F6WQW2 P43487-2 RANBP1 Ran-specific GTPase-activating protein 1 2294280.0 1194600.0 664220.0 435460.0 True False 1566132.168522858 565120.9651092818 390402.77642727486 1.0 0.36083861660430083 0.24927830758721617 20.578774538547258 -13.999999999999998 0.24555655181125163 5.347437341107915 0.2024867483310103 0.999534538536061 0.007135767450750929 13.82622263694625 0.1568157177222481 29.57114668373541 0.05278820602715283 1.0000000000000041e-14 13.999999999999998 -5.144950592776905 EETK(ub)EDAEEKQ ddPTM_RPMI8226_Bortezomib_2h_R1 1 EETKEDAEEKQ 11 2 P43487-2;P43487;F6WQW2 P43487-2 RANBP1 Ran-specific GTPase-activating protein 1 3018880.0 1176700.0 1361600.0 480580.0 True False 1139346.3025930156 1905293.9806501989 354701.6809090371 1.0 1.6722694200296944 0.311320342289064 20.1197748880104 -6.772369970613346 1.5651822156890447 1.384423632118429 0.30293338052958313 0.7396163644449334 0.28351994587689333 0.2626128642345945 1.2699535782400038 0.14274680573204965 0.33909103571800336 1.6890014771288446e-07 6.772369970613346 -1.0814902515888458 EETK(ub)EDAEEKQ ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EETKEDAEEKQ 11 2 P43487-2;P43487;F6WQW2 P43487-2 RANBP1 Ran-specific GTPase-activating protein 1 2829620.0 1194600.0 967790.0 667230.0 True False 1636275.9028511408 925029.8377464433 509644.0160331992 1.0 0.565326321884114 0.31146582012554624 20.64198460007015 -8.909914251900805 0.1843846531864119 1.4111429531689577 3.1362459689450737e-13 0.9997013917547154 0.00491287367364828 0.3998841347556369 0.0576937227958776 0.2413633802395402 0.14531854272941014 1.2305117018835528e-09 8.909914251900805 -1.4111429531686441 down EETK(ub)EDAEEKQ ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EETKEDAEEKQ 11 2 P43487-2;P43487;F6WQW2 P43487-2 RANBP1 Ran-specific GTPase-activating protein 1 2524460.0 1176700.0 1077400.0 270360.0 True False 978478.1866486741 1071595.8323528448 326891.02599659836 1.0 1.0951657859876287 0.3340810561308606 19.900180163444677 -6.87556319541586 1.104298392505586 1.0561306844156846 0.28454108023438685 0.9699244528040092 0.05871833127581054 0.13163016248079595 0.2966844282947453 0.0411118351846009 0.09838629280253451 1.3317932352201458e-07 6.87556319541586 -0.7715896041812977 down EETPGAGQK(ub)QELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EETPGAGQKQELR 13 1 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 192703200.0 58336000.0 61546400.0 72820800.0 True False 76479060.92662768 52363917.02598816 65286002.162438154 1.0 0.6846830543097927 0.8536454471515034 26.188561473032095 -10.055945940159427 4.851541490050174 1.0000060699546518 0.7691642514335703 0.713356614247836 0.06897860804030585 4.528890917542583e-06 8.81307636816356e-07 0.06679000583132987 0.02226275001396659 8.791319420637483e-11 10.055945940159427 -0.23084181852108154 EETPGAGQK(ub)QELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EETPGAGQKQELR 13 1 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 164273300.0 35133500.0 30815700.0 98324100.0 True False 34018206.27360564 43120569.71175255 72570068.55022733 1.0 1.2675732919289557 2.1332714595987876 25.01980373618291 -6.949741501321827 0.5616756965684591 0.9887755627552335 2.4535613721431737 0.999180831565468 0.01384285626396023 0.08358973857249538 0.03639342574842971 0.014808897751746581 0.0719894512181219 1.1226864955383475e-07 6.949741501321827 1.4647858093879402 up EETPGAGQK(ub)QELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EETPGAGQKQELR 13 1 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 329843000.0 48914000.0 144456000.0 136473000.0 True False 74206114.09239843 118676698.1601206 109499051.73175907 1.0 1.5992846359310664 1.4756068697441198 26.145034724472524 -10.165545279638355 4.537364902603693 0.9999129684203307 1.5374457528141219 0.9618002813490261 0.05049123664960902 4.491592086407517e-05 8.260410244940331e-06 0.04889588497973006 0.01629597655110738 6.830534989584293e-11 10.165545279638355 0.5375327843937912 EETPGAGQK(ub)QELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EETPGAGQKQELR 13 1 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 182068500.0 58336000.0 34822600.0 88909900.0 True False 79904395.6711235 33284022.38906091 67911212.7768688 1.0 0.41654807735551597 0.8499058431826813 26.251771534554987 -9.804108187201779 6.2044694456763985 1.0000000139483614 0.6332269602688515 0.48851234005998667 0.17691756705913822 3.397654077534894e-08 6.788221977151955e-09 0.17129970409887565 0.05709989923915718 1.5699716596026122e-10 9.804108187201779 -0.36677305367950985 EETPGAGQK(ub)QELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EETPGAGQKQELR 13 1 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 280611000.0 48914000.0 112558000.0 119139000.0 True False 63320137.23908768 106294048.35356613 97456924.46937177 1.0 1.6786768473387095 1.5391142331449554 25.916161046564973 -10.090052897303092 4.622338824068626 0.9999696415460398 1.6088955401953393 0.9620920329160506 0.056976198877194004 6872725.528506555 15002398.898976047 1580.37065964466 0.019504467746247624 8.127315189961108e-11 10.090052897303092 0.6089258986492995 EETPGQRPAVTETHQLAELNEK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EETPGQRPAVTETHQLAELNEKK 23 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L1I8;I3L182;Q9UQ35-3;I3L1C0;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 18337800.0 10510500.0 4630600.0 3196700.0 True False 10176849.93065683 6479622.728259984 2359388.371055635 1.0 0.6367021988543541 0.23183877006461434 23.278787733218746 -7.457054775884693 0.35785238711150513 1.0527340448705556 5.725643440526811e-13 0.9994274950122602 0.007507201910682105 0.11845398595916995 0.03746463890405506 0.01813307924299115 0.06276199973498005 3.490962825367412e-08 7.457054775884693 -1.052734044869983 down EETPGQRPAVTETHQLAELNEK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EETPGQRPAVTETHQLAELNEKK 23 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L1I8;I3L182;Q9UQ35-3;I3L1C0;A0A087X1W1 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 26256600.0 10510500.0 11326000.0 4420100.0 True False 8739946.444098657 11264984.589965029 5344322.473766704 1.0 1.2889077366797042 0.6114822908755089 23.059193008653022 -6.790818130887344 1.4930003579950304 1.1612996951025851 0.6041083058611133 0.8039780339929965 0.12288465167436222 0.23413684083636274 1.0310077956302308 0.06478137669484368 0.15158325589879956 1.6187577814757651e-07 6.790818130887344 -0.5571913892414718 EETQPPVALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EETQPPVALK 10 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 4703770.0 1300500.0 505070.0 2898200.0 False True 1259216.33935771 706747.0849052557 2139074.4758636854 1.0 0.5612594617901377 1.6987346883973613 20.264094735546983 -6.802126729816559 1.4471422688369076 0.7585743426959906 1.7152857792692136 0.8383218619365836 0.1883393323274954 0.21773945668239478 0.8999997635125355 0.10237286120286611 0.23778750790761616 1.5771509801319817e-07 6.802126729816559 0.956711436573223 EETQPPVALK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EETQPPVALKK 11 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 4616690.0 1714200.0 1966500.0 935990.0 True False 1659783.6593056398 2751733.705162026 690826.1399018889 1.0 1.6578869720365825 0.4162145687052322 20.662563778374157 -6.7627395427394115 1.602008046654423 1.380829800881074 0.41102856636069685 0.702115702990905 0.2768298070840973 0.2783346175779454 1.4084260569045555 0.13629889859694752 0.32668753359418456 1.7268732305578127e-07 6.7627395427394115 -0.9698012345203771 EEVEQMK(ub)SCLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEVEQMKSCLR 11 1 Q9NZL4;Q9NZL4-3;Q9NZL4-2;K7ERT9;K7EKM6;K7EL16 Q9NZL4 HSPBP1 Hsp70-binding protein 1 1 8029500.0 2475000.0 2490500.0 3064000.0 True False 3244748.967934093 2118927.1078929626 2746966.6719633746 1.0 0.6530326779769553 0.8465883490864772 21.629675436847293 -10.517713069198686 8.15921118385933 1.00002905268791 0.7498105135317178 0.6901859694547717 0.07901877184004802 4.176559016042985e-05 2.4687529658764596e-06 0.07651845831563917 0.025503198947855802 3.0358962855618e-11 10.517713069198686 -0.2502185391561923 EEVEQMK(ub)SCLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEVEQMKSCLR 11 1 Q9NZL4;Q9NZL4-3;Q9NZL4-2;K7ERT9;K7EKM6;K7EL16 Q9NZL4 HSPBP1 Hsp70-binding protein 1 1 29431100.0 6100800.0 6182300.0 17148000.0 True False 9255359.628223104 5079020.262469629 13758690.283764616 1.0 0.5487653064265345 1.4865646324329902 23.141857618174637 -6.775854562622394 1.5519140986677789 0.7431259738596019 1.4930647096546505 0.7524928188261983 0.1905157562817333 0.25706486752925084 1.2225434496230685 0.09671788904801776 0.2290273046334467 1.6755038780716807e-07 6.775854562622394 0.7499387357950487 EEVEQMK(ub)SCLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEVEQMKSCLR 11 1 Q9NZL4;Q9NZL4-3;Q9NZL4-2;K7ERT9;K7EKM6;K7EL16 Q9NZL4 HSPBP1 Hsp70-binding protein 1 1 7921700.0 2475000.0 2202500.0 3244200.0 True False 3390074.384360093 2105186.2673064796 2477986.776396301 1.0 0.6209852730720693 0.7309535117660975 21.692885498370185 -10.383980093284233 8.5897317319454 1.0000016563049314 0.6759693924190842 0.9204864508369731 0.04489434545215903 1.4239864387778824e-06 1.0210356355022981e-07 0.04346898519583765 0.0144895876895912 4.1306643524400415e-11 10.383980093284233 -0.32403226388584727 EEVK(ub)TFQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEVKTFQGK 9 1 Q71RC2-5;Q71RC2-3;Q71RC2;Q71RC2-4;Q96J85;Q71RC2-7;Q71RC2-6;Q71RC2-2;X6RLN4;Q92615 Q71RC2-5;Q92615 LARP4;LARP4B La-related protein 4;La-related protein 4B 1 2082250.0 521860.0 567410.0 992980.0 True False 505293.8399517222 793979.7720040594 732888.7492385355 1.0 1.571322880326266 1.4504209061969935 18.94676306657302 -10.05385526209699 4.500181189492635 0.9999729778242588 1.5108718932894967 0.9596880217568184 0.04935802437606247 7607541.726928583 8498005.57954782 1701.8855132724457 0.016896564277163857 8.833742546856103e-11 10.05385526209699 0.5108989154652379 EEVK(ub)TFQGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEVKTFQGK 9 1 Q71RC2-5;Q71RC2-3;Q71RC2;Q71RC2-4;Q96J85;Q71RC2-7;Q71RC2-6;Q71RC2-2;X6RLN4;Q92615 Q71RC2-5;Q92615 LARP4;LARP4B La-related protein 4;La-related protein 4B 1 1615220.0 521860.0 562070.0 531290.0 True False 433949.7123179038 559042.0173478406 642380.2825925905 1.0 1.2882645188581123 1.48031042389998 18.727168342007296 -8.285323864636885 0.06698508181827527 5.561658708425386e-24 2.5201752549365635 0.9999967343239772 0.00035666584849651604 0.08781054134588437 0.014011622155619597 0.2580363253811125 0.2572739853369535 5.1841330052911275e-09 8.285323864636885 2.5201752549365635 EEVK(ub)TFQGKPIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEVKTFQGKPIK 12 2 Q92615 Q92615 LARP4B La-related protein 4B 1 3831600.0 1199100.0 1433000.0 1199500.0 True False 1572031.712100919 1219201.985790251 1075387.2464164686 1.0 0.7755581369035273 0.6840747792417513 20.5841988902472 -13.9999999999885 0.12347026099167316 2.0675799220628943 0.544662631297597 0.9996760966190348 0.0023887528420932693 11.951756591843974 0.10857330541162084 3.1173950698420136 0.12376324667207055 1.00000000002648e-14 13.9999999999885 -1.5229172907652972 EEVK(ub)TFQGKPIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEVKTFQGKPIK 12 2 Q92615 Q92615 LARP4B La-related protein 4B 1 5616000.0 1391100.0 1959500.0 2265400.0 True False 1346940.2919496433 2741938.5686575095 1672023.7794567633 1.0 2.035679372757244 1.2413495902157432 20.361254468812312 -10.11076374537059 4.418954254511631 0.9999297928974369 1.6385144815212291 0.46281213610091865 0.32428377592211316 112985048.54249318 12.83215999073778 86343.59913499381 0.11101096192075346 7.748832168378588e-11 10.11076374537059 0.6385846886237923 EEVK(ub)TFQGKPIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEVKTFQGKPIK 12 2 Q92615 Q92615 LARP4B La-related protein 4B 1 11478700.0 1788400.0 2240500.0 7449800.0 True False 2713133.549553202 1840665.2698935992 5977343.764636669 1.0 0.6784278164990144 2.203114463577002 21.37152863299116 -6.851614534450518 1.227311727787779 0.8281357970143511 2.2659771309870655 0.9426170887525238 0.15719452069099837 0.15569030048152205 0.45048067446179185 0.10018082771366114 0.2320708762311199 1.407296039822326e-07 6.851614534450518 1.4378413339727145 up EEVK(ub)TFQGKPIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEVKTFQGKPIK 12 2 Q92615 Q92615 LARP4B La-related protein 4B 1 3271110.0 1199100.0 943610.0 1128400.0 True False 1642439.6744590674 901918.1900990099 861895.160127485 1.0 0.5491332218311482 0.5247651853096813 20.647408951770093 -13.999999999999998 0.41579533013670483 9.416042543203398 0.523845789329351 0.999858907508744 0.0025955166023503575 29.249205220615 0.2145010620267451 223.3429602307508 0.0059771191796973 1.0000000000000041e-14 13.999999999999998 -8.892196753874046 EEVK(ub)TFQGKPIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEVKTFQGKPIK 12 2 Q92615 Q92615 LARP4B La-related protein 4B 1 4814900.0 1391100.0 1755000.0 1668800.0 True False 1156761.286179121 1745545.4666597762 2017738.364340597 1.0 1.5089936770147785 1.7442996999020908 20.14165974424659 -10.834562953539848 0.15112697246701984 1.6767994464503902e-17 2.0611392484691344 0.9996535338474846 0.005781961917596362 2.9040167056536466 0.0853574300318614 1.2474313354679953 0.2172119609382892 1.4636493575884615e-11 10.834562953539848 2.0611392484691344 EEVK(ub)TFQGKPIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEVKTFQGKPIK 12 2 Q92615 Q92615 LARP4B La-related protein 4B 1 13501500.0 1788400.0 2986200.0 8726900.0 True False 2315119.0546343457 2820015.3449192294 7138693.74555569 1.0 1.2180865339405311 3.0835104273646907 21.14265495508361 -6.928872591387203 0.7559877318213855 0.9704139121559026 3.4557060235286396 0.9963119973162365 0.05678284174410617 0.09322754930794057 0.08057886046480137 0.05138909561932325 0.16984727293774035 1.1779514974914053e-07 6.928872591387203 2.485292111372737 up EEVQLTSK(ub)QK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEVQLTSKQK 10 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 1678730.0 302690.0 637370.0 738670.0 True False 396829.5212541295 542276.8804488014 662239.5142229715 1.0 1.366523535686065 1.668826230795651 18.598159830259114 -6.9733324538947326 0.1596310892206282 0.6924900007729133 2.3508781048976006 0.9999980830692875 0.0003785791716547165 0.07523551674970493 0.004925797237735819 0.014041540323525618 0.0363260618037833 1.0633287248567349e-07 6.9733324538947326 1.6583881041246873 EEVQLTSK(ub)QK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEVQLTSKQK 10 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 2083410.0 422660.0 577250.0 1083500.0 True False 409242.8896523873 807748.9353189818 799698.8456967436 1.0 1.9737641282053482 1.9540934391701008 18.642597825400497 -10.422224551077955 5.861609053218658 0.9996043135803686 1.9639287836877253 0.9996877696507452 0.008030525170888536 4.154123544913013e-05 4.094689150625439e-06 0.007778490376641096 0.0025918408540121876 3.782469623263417e-11 10.422224551077955 0.9643244701073567 EEVQLTSK(ub)QK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EEVQLTSKQK 10 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 2070800.0 422660.0 728820.0 919320.0 True False 351460.5170127719 724893.702000556 1111545.5615445818 1.0 2.0625181689305196 3.1626470335619197 18.423003100834773 -6.970688595820174 0.24117408304790264 0.6106819425396353 4.646349108087107 0.99998726610043 0.003150735095832917 0.0760799190509996 0.008226604977584871 0.026080124743959446 0.10702844148029349 1.0698217034711812e-07 6.970688595820174 4.035667165547472 EEVVLLTHGDSVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEVVLLTHGDSVDK 14 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 9890300.0 1069500.0 4872500.0 3948300.0 False True 1402124.8570527334 4145541.992856238 3539767.7907679435 1.0 2.956614007664173 2.524573880109747 20.419183394158004 -10.134128526747892 5.043226059451715 0.9999252044250777 2.7405939438904765 0.9558331343323336 0.17637964349815094 0.00014835038345304598 2.54702542933033e-05 0.17078606234929788 0.056926285154770793 7.342965255132903e-11 10.134128526747892 1.7406687394653988 EEVVLLTHGDSVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEVVLLTHGDSVDK 14 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 8343900.0 1069500.0 2074600.0 5199800.0 False True 1464923.0521507566 1982937.3122152213 3971714.333242547 1.0 1.3536119247382528 2.711210208216325 20.482393455680896 -6.9458177672260275 0.6030139812018979 0.984804261564822 3.1498744942033943 0.9988308640321886 0.025220151310775093 0.08520985853129344 0.04325664005133549 0.025808178360089987 0.11420251878040258 1.1328756254578249e-07 6.9458177672260275 2.1650702326385725 up EEVVQK(ub)EQE ddPTM_RPMI8226_Bortezomib_1h_R1 1 EEVVQKEQE 9 1 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 1 4785740.0 1818200.0 2002300.0 965240.0 True False 2383677.8074738444 1703564.644904268 865366.2240358768 1.0 0.7146790726342578 0.36303825178158955 21.184757814783385 -6.968316332894833 0.2956501454454294 1.0642263810669828 0.0025402636149707597 0.9999661085490626 0.001516571636021938 0.07685291053465557 0.010975352667666749 0.005963457582670747 0.031685616488896846 1.0756814197147606e-07 6.968316332894833 -1.061686117452012 down EEVVQK(ub)EQE ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EEVVQKEQE 9 1 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 1 3533600.0 1818200.0 1715400.0 0.0 True False 2490437.6750074825 1639607.95593078 0.0 1.0 0.6583613685196333 0.0 21.247967876306276 -7.515822022515746 0.7090171000275312 0.9935866786578319 5.587222587522486e-17 0.9870705496128085 0.04719071607345635 0.1195683479204397 0.1430005787032432 0.04181883515610155 0.07584730255081684 3.049144298269803e-08 7.515822022515746 -0.9935866786578318 down EEYEGPNKKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EEYEGPNKKPR 11 2 P23246 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 3958100.0 1426000.0 480900.0 2051200.0 False True 1380732.410552935 672925.8778603701 1513929.185319023 1.0 0.48736878537593453 1.0964682032145152 20.39700231804788 -6.683581919162195 1.889473668541877 0.6766885737000288 1.0941988311444986 0.3403985887285964 0.21709930980978506 0.4306458116291062 2.975596036660476 0.09209968898306847 0.24176999446448377 2.072135164477759e-07 6.683581919162195 0.4175102574444698 EEYMLNNAVGSCQKPYVALIHGITMGGGVGLSVHGQFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EEYMLNNAVGSCQKPYVALIHGITMGGGVGLSVHGQFR 38 1 Q6NVY1;Q6NVY1-2;B8ZZZ0 Q6NVY1 HIBCH 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial 0 135650000.0 39585000.0 23139000.0 72926000.0 False True 60053339.051142715 19009664.66416785 58512144.135398775 1.0 0.31654633971274787 0.9743362327541617 25.83974112827067 -10.855216452830996 10.971666500142028 1.00914474013702 0.6454412864622796 0.27921855187183553 0.2685415993185645 0.05849870293957495 0.0007719550909562234 0.2532128495449793 0.08667142849372542 1.3956725829845282e-11 10.855216452830996 -0.36370345367474033 EEYMLNNAVGSCQKPYVALIHGITMGGGVGLSVHGQFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EEYMLNNAVGSCQKPYVALIHGITMGGGVGLSVHGQFR 38 1 Q6NVY1;Q6NVY1-2;B8ZZZ0 Q6NVY1 HIBCH 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial 0 77062000.0 39585000.0 20810000.0 16667000.0 False True 51243562.837005526 19651905.206539832 13633777.017861638 1.0 0.3834999777249722 0.2660583351947576 25.61086745036312 -13.999999999999998 0.23315163883597378 4.949407361150963 0.2106429599942516 0.9995142562979239 0.00709438583072264 13.391461978973048 0.15286513520435552 24.52723477007159 0.05978970787093864 1.0000000000000041e-14 13.999999999999998 -4.738764401156712 EFCENLSADCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFCENLSADCR 11 0 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0 10690100.0 1877000.0 5505100.0 3308000.0 False True 2460765.176893856 4683760.53871173 2965719.8925766405 1.0 1.9033756583892696 1.2052023169151689 21.230675561823833 -10.21666441331495 4.784932157997721 0.9999010301337097 1.5542889876537764 0.45663910062790425 0.285028073109844 0.00030100266737158766 4.927656839378087e-05 0.27602618777889965 0.09199241502887255 6.072053461884428e-11 10.21666441331495 0.5543879575200668 EFCENLSADCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFCENLSADCR 11 0 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0 6611100.0 1877000.0 2147100.0 2587000.0 False True 2570977.624017736 2052234.0224897848 1976003.8809374382 1.0 0.7982309932681185 0.7685807385011324 21.293885623346725 -13.999999999999998 0.270055883757206 2.5577938749150237 0.7587440761808477 0.9995834455183595 0.0020984827788589166 14.885844587931045 0.16450767293185822 12.731569628003358 0.012310993367063778 1.0000000000000041e-14 13.999999999999998 -1.799049798734176 EFDPLGPLPPGWEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFDPLGPLPPGWEKR 15 1 A0A590UJQ1;Q96J02-3;Q96J02-2;Q96J02;A0A590UK44;A0A590UJW8;A0A590UK95 A0A590UJQ1 ITCH E3 ubiquitin-protein ligase Itchy homolog 1 41320000.0 10765000.0 19167000.0 11388000.0 True False 14113019.2484083 16307358.312380813 10209679.001409559 1.0 1.1554833182998736 0.7234227362483779 23.750523326047556 -6.8093651253656455 1.4171071720614044 1.0848024759722248 0.7159669753552226 0.8581772548624782 0.0672906249146528 0.20767355178302271 0.8220722611409874 0.037337664822923514 0.08639854459274464 1.551082416658334e-07 6.8093651253656455 -0.3688355006170022 EFDPLGPLPPGWEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFDPLGPLPPGWEKR 15 1 A0A590UJQ1;Q96J02-3;Q96J02-2;Q96J02;A0A590UK44;A0A590UJW8;A0A590UK95 A0A590UJQ1 ITCH E3 ubiquitin-protein ligase Itchy homolog 1 52596100.0 16414000.0 18828000.0 17354100.0 True False 15892946.554569356 26346118.586722918 12808540.598159539 1.0 1.657723978134702 0.8059261103144512 23.921883289563446 -6.70054479554781 1.8293924625342661 1.4082098479130265 0.808471855121088 0.41999289890687097 0.2776062474245177 0.3943680610815472 2.566413214220594 0.12105692243140402 0.31106345577479205 1.9927609511183722e-07 6.70054479554781 -0.5997379927919385 EFDPLGPLPPGWEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFDPLGPLPPGWEKR 15 1 A0A590UJQ1;Q96J02-3;Q96J02-2;Q96J02;A0A590UK44;A0A590UJW8;A0A590UK95 A0A590UJQ1 ITCH E3 ubiquitin-protein ligase Itchy homolog 1 112935300.0 33898300.0 39861000.0 39176000.0 True False 51426199.397684716 32747493.114585534 31432846.42854918 1.0 0.6367861809375684 0.6112224274143878 25.616000200893943 -13.999999999999998 0.37680600078319326 6.281055109635676 0.6088498162978913 0.999802319481542 0.0024963698154192504 23.63764795795835 0.1998873352445614 101.12655990174466 0.00699635523118746 1.0000000000000041e-14 13.999999999999998 -5.672205293337784 EFDPLGPLPPGWEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFDPLGPLPPGWEKR 15 1 A0A590UJQ1;Q96J02-3;Q96J02-2;Q96J02;A0A590UK44;A0A590UJW8;A0A590UK95 A0A590UJQ1 ITCH E3 ubiquitin-protein ligase Itchy homolog 1 41289000.0 10765000.0 16537000.0 13987000.0 True False 14745111.41318644 15806340.65945392 10683558.671307266 1.0 1.071971599028979 0.7245491995233784 23.813733387570448 -6.852668096835953 1.2220592723697166 1.0385152995725457 0.7099226258381812 0.944105087597042 0.03539789527588232 0.15455125371472117 0.44280516243075146 0.02264829174660424 0.052509618588072286 1.4038861940481896e-07 6.852668096835953 -0.3285926737343645 EFDPLGPLPPGWEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFDPLGPLPPGWEKR 15 1 A0A590UJQ1;Q96J02-3;Q96J02-2;Q96J02;A0A590UK44;A0A590UJW8;A0A590UK95 A0A590UJQ1 ITCH E3 ubiquitin-protein ligase Itchy homolog 1 55837700.0 16414000.0 28316700.0 11107000.0 True False 13648968.263492256 28164152.316675153 13429422.347034385 1.0 2.063463829131141 0.9839148342776132 23.702288564997723 -6.6496027437052225 2.0097942560316238 1.690297100571057 0.9884398248544007 0.19248521752120296 0.4539420931197673 0.5095186092292715 3.944381773227268 0.18319970028393223 0.502838038657495 2.2407698704205662e-07 6.6496027437052225 -0.7018572757166562 EFDPLGPLPPGWEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFDPLGPLPPGWEKR 15 1 A0A590UJQ1;Q96J02-3;Q96J02-2;Q96J02;A0A590UK44;A0A590UJW8;A0A590UK95 A0A590UJQ1 ITCH E3 ubiquitin-protein ligase Itchy homolog 1 84350300.0 33898300.0 31841000.0 18611000.0 True False 43882017.585389994 30069020.35951151 15223988.964986088 1.0 0.685224199206434 0.34693001376615684 25.387126522986392 -7.158936544575303 0.27818075401036646 1.0851868668158697 2.293655758865261e-13 0.9999565953171272 0.0017568872806479558 0.08388224558082216 0.013017883671086675 0.009107341650862332 0.036134496840486835 6.935271309137974e-08 7.158936544575303 -1.0851868668156404 down EFEEESK(ub)QPGVSEQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFEEESKQPGVSEQQR 16 1 O94776 O94776 MTA2 Metastasis-associated protein MTA2 1 29658400.0 5200500.0 6752900.0 17705000.0 True False 7889538.707476762 5547792.234351476 14205598.989622824 1.0 0.7031833469672873 1.8005614163677852 22.911509519259873 -6.834670359098788 1.3068581819763176 0.8418379517179763 1.833022021339511 0.9149068774409636 0.1351974692117756 0.17511621104209563 0.5832351391405098 0.08118310179980763 0.18685248550839947 1.463287426579914e-07 6.834670359098788 0.9911840696215347 EFEEESK(ub)QPGVSEQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFEEESKQPGVSEQQR 16 1 O94776 O94776 MTA2 Metastasis-associated protein MTA2 1 28883500.0 5200500.0 4374000.0 19309000.0 True False 6732149.767180679 4130583.0549449837 15794960.127070887 1.0 0.6135607789181446 2.346198565586216 22.682635841352322 -6.848185776866868 1.243963171940834 0.7940732049693383 2.413017757364972 0.9376012688148176 0.18550937732667402 0.15946667746902546 0.4757989965551956 0.1167503407892452 0.26984879445568694 1.4184506254617433e-07 6.848185776866868 1.6189445523956336 up EFEK(ub)DKDDDEVFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFEKDKDDDEVFEK 14 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 3761200.0 1148900.0 1014100.0 1598200.0 True False 1112428.7983760654 1419035.4184616369 1179583.475027723 1.0 1.275619096281181 1.0603676179092905 20.085281567859766 -10.12099487257082 4.593763864080674 0.9999846098269938 1.167993357098833 0.4481661228087791 0.08787604807752888 1.3855712463058817e-05 2.6511806969298164e-06 0.08509341225416321 0.028361872559486388 7.568418305017129e-11 10.12099487257082 0.16800874727183923 EFEPDAIGGGAK(ub)QPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFEPDAIGGGAKQPK 15 1 Q8WU76;Q8WU76-2;A0A087WUD7 Q8WU76 SCFD2 Sec1 family domain-containing protein 2 1 5520700.0 1737700.0 1385500.0 2397500.0 True False 2380174.6495767795 1324284.0287641904 1831259.8780624308 1.0 0.5563810323749403 0.7693804647436474 21.1826360070733 -10.13361955070412 5.007290812939247 1.000013796135669 0.6628807485618317 0.7695862674750759 0.08695665414253607 121461656.151633 3.3723973269883065 21668.06845706182 0.02976757562310753 7.35157596619588e-11 10.13361955070412 -0.33713304757383733 EFEPDAIGGGAK(ub)QPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFEPDAIGGGAKQPK 15 1 Q8WU76;Q8WU76-2;A0A087WUD7 Q8WU76 SCFD2 Sec1 family domain-containing protein 2 1 6931100.0 2313000.0 2759900.0 1858200.0 True False 1923361.983273885 2745031.8709027413 2246741.028653943 1.0 1.4272050164110222 1.1681321811454402 20.875198877674457 -10.130473791471871 4.173884858254551 0.9999430348910039 1.2976685986804755 0.6377068823612304 0.1057660425217576 14877132.721581299 12036146.810887456 8308.583265790172 0.036206529569893856 7.405019534450857e-11 10.130473791471871 0.29772556378947157 EFEPDAIGGGAK(ub)QPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFEPDAIGGGAKQPK 15 1 Q8WU76;Q8WU76-2;A0A087WUD7 Q8WU76 SCFD2 Sec1 family domain-containing protein 2 1 25257500.0 6441600.0 4570900.0 14245000.0 True False 8338778.1829191465 4316525.396855974 11652556.166043034 1.0 0.5176448278355442 1.3973937080988328 22.99140458146231 -6.75783151710914 1.6205173627373564 0.7190647065137549 1.4002797710107884 0.6820790253304605 0.20282277835663806 0.28658499467673176 1.4827624533743542 0.09877303822811465 0.23788913969167916 1.7464995693703135e-07 6.75783151710914 0.6812150644970335 EFEPLLNWMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 EFEPLLNWMK 10 0 P14625 P14625 HSP90B1 Endoplasmin 0 31240760.0 4522960.0 13682300.0 13035500.0 False True 5929644.360406941 11640954.173187666 11686711.50534548 1.0 1.9631791496495024 1.9708958573264994 22.499514148823394 -11.016905857396031 0.8029673436311651 4.132174858846221e-09 1.9692319934572058 0.999991539210254 0.0013260160026309408 3.245350965776264 0.4293691844628805 5.984595163301122 0.0011118051824405366 9.61820750976318e-12 11.016905857396031 1.969231989325031 EFEPLLNWMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 EFEPLLNWMK 10 0 P14625 P14625 HSP90B1 Endoplasmin 0 8962200.0 1226900.0 6737190.0 998110.0 False True 1187952.7310711069 9427385.100981722 736675.0483418353 1.0 7.935825100112868 0.6201215158431589 20.180046001417377 -6.65820905915948 1.9790515415645145 5.471026001712898 0.6505582457390338 0.22810825790108558 2.9543759235753986 0.4886913965690385 3.6774714189025954 1.2068182965838454 3.274856549641715 2.1968021292894598e-07 6.65820905915948 -4.820467755973865 EFEPLLNWMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EFEPLLNWMK 10 0 P14625 P14625 HSP90B1 Endoplasmin 0 46776660.0 4522960.0 16156300.0 26097400.0 False True 6195220.54039811 15442461.24426049 19933731.61282439 1.0 2.492641084132922 3.217598386181654 22.562724210346286 -9.180017573644827 0.23875246016641563 4.360377254390787e-24 3.7443789500478153 0.9992248160714075 0.02570485269720404 0.614109189984569 0.08614624260572495 0.818949891992664 0.32693403615983313 6.606667137119336e-10 9.180017573644827 3.7443789500478153 EFEVEK(ub)QTAEETGLTPLETSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFEVEKQTAEETGLTPLETSR 21 1 Q5T8C6;Q13042-4;Q13042-3;Q13042-2;Q13042 Q5T8C6 CDC16 Cell division cycle protein 16 homolog 1 17273300.0 3699900.0 2925400.0 10648000.0 True False 3582448.6997228693 4093527.4757594657 7858969.366847191 1.0 1.1426618547464846 2.1937423325713343 21.77251461472288 -6.93166178378622 0.7330250332907056 0.9849610954278258 2.418947176242456 0.9968548850097679 0.029852403071710307 0.09178397520337435 0.07352036966764883 0.027470968169280997 0.09425051282062182 1.1704105186800468e-07 6.93166178378622 1.43398608081463 up EFEVEK(ub)QTAEETGLTPLETSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFEVEKQTAEETGLTPLETSR 21 1 Q5T8C6;Q13042-4;Q13042-3;Q13042-2;Q13042 Q5T8C6 CDC16 Cell division cycle protein 16 homolog 1 16871700.0 3699900.0 5505100.0 7666700.0 True False 3076630.783361461 5475442.933623208 9269771.523184352 1.0 1.7796880156158537 3.012961962584408 21.552919890157156 -6.96436056385699 0.3688670385147744 0.903933781311553 3.9315679482716415 0.9998993446557056 0.008314242818831627 0.07817868058315099 0.01562949638468606 0.0162840124847682 0.10480526421935601 1.0855240159212867e-07 6.96436056385699 3.0276341669600884 EFFNGKEPSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFFNGKEPSR 10 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 4831910.0 1597000.0 577610.0 2657300.0 False True 1546304.1091536037 808252.685196357 1961273.4127087786 1.0 0.5226996943303527 1.2683620260068478 20.560392649015224 -6.733814891931598 1.709245008880778 0.7139882467968843 1.26824192524289 0.576864716714292 0.2005931952469844 0.3291462956835232 1.885523642490188 0.09293559557961172 0.2296307270714446 1.8458019823274573e-07 6.733814891931598 0.5542536784460057 EFGFQNNGFSVYINR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFGFQNNGFSVYINR 15 0 Q8TAT6;Q8TAT6-2;A0A0D9SFI9;I3L4U9 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 0 32375200.0 10257000.0 14158000.0 7960200.0 False True 15560618.887143366 11631394.283041097 6386862.980920395 1.0 0.7474891819792137 0.41045044719894824 23.891396105490433 -6.967124287936043 0.31950105616118485 1.0464284608606402 0.10064815198334813 0.9999504747381458 0.0016995676808468395 0.07724732449731209 0.012356090643557707 0.005119213399764825 0.029659813727802978 1.0786379896071312e-07 6.967124287936043 -0.9457803088772921 down EFGFQNNGFSVYINR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFGFQNNGFSVYINR 15 0 Q8TAT6;Q8TAT6-2;A0A0D9SFI9;I3L4U9 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 0 22671100.0 10257000.0 7434300.0 4979800.0 False True 13277888.695696983 7020574.6697250875 4073527.497062906 1.0 0.5287417925110542 0.30679030306851646 23.662522427582882 -10.888168308331034 0.14754558252384567 1.9620537016172221 4.2504055967277896e-15 0.9996774343275026 0.005191151200727499 2.9898189257292147 0.0838502432072751 1.1984932374355386 0.20951460980733122 1.293694380463435e-11 10.888168308331034 -1.962053701617218 EFGLCK(ub)TENK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFGLCKTENK 10 1 Q9BVP2-2;Q9BVP2;C9JZT7;B4DMU5 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 1 7853700.0 1434400.0 1760600.0 4658700.0 True False 1856859.0762511229 1662621.0623082176 3810864.4022986726 1.0 0.8953943159030361 2.052317513503803 20.824432897409345 -6.884817953417308 1.0525304080655808 0.9298980070747089 2.142287558592385 0.9773697295582525 0.07859723376901066 0.12344935407490679 0.24720481222168017 0.05724936770158539 0.1403077768613059 1.3037131514728627e-07 6.884817953417308 1.212389551517676 up EFGTNIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFGTNIK 7 0 P14625;Q58FF3 P14625 HSP90B1;HSP90B2P Endoplasmin;Putative endoplasmin-like protein 0 11047570.0 359270.0 6220900.0 4467400.0 False True 471006.44917562907 5292765.968878276 4005156.3023267556 1.0 11.237141185947344 8.50340013249651 18.845387288266377 -9.582512102378425 9.669787226538483 1.00004054271367 9.870270659221926 0.9335007223085929 1.1160451118876509 0.0 0.0 1.080606048979984 0.36020201095945065 2.615097572836228e-10 9.582512102378425 8.870230116508257 EFGTNIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFGTNIK 7 0 P14625;Q58FF3 P14625 HSP90B1;HSP90B2P Endoplasmin;Putative endoplasmin-like protein 0 10945100.0 3594400.0 1003200.0 6347500.0 False True 3480297.7394750835 1403782.9916188875 4684899.329081757 1.0 0.40335140746625125 1.3461202689481266 21.730779303240066 -6.735689667179345 1.702600067049797 0.6432343881168687 1.346157585075289 0.5853993919368059 0.2507244572926497 0.3256646557425924 1.8519229586414163 0.1165827242940515 0.2874347604995868 1.8378511433637626e-07 6.735689667179345 0.7029231969584202 EFGTNIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFGTNIK 7 0 P14625;Q58FF3 P14625 HSP90B1;HSP90B2P Endoplasmin;Putative endoplasmin-like protein 0 11850270.0 359270.0 5929500.0 5561500.0 False True 492101.8279066873 5667515.0837656185 4247988.242687883 1.0 11.516955967983717 8.632335833333643 18.908597349789268 -10.39528361394365 7.83493215001961 0.9998340727063895 10.07464590065868 0.9295543867471608 1.177641238608531 0.0034132769589569592 0.00026345129092646347 1.140256881274779 0.38008207541149325 4.024541277378942e-11 10.39528361394365 9.07481182795229 EFHLNESGDPSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFHLNESGDPSSK 13 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 64155100.0 1596500.0 29222700.0 33335900.0 False True 2093026.9605279947 24862787.069192458 29886620.848532587 1.0 11.878866129330929 14.279138019795635 20.997159464563055 -9.132113300934328 0.5700158559038901 4.44255528734028e-18 14.138269377498895 0.9972733839434411 0.30169932782392844 0.5600813444723253 0.24035666820981377 2.037845505437798 0.43368834993461347 7.377117470617996e-10 9.132113300934328 14.138269377498895 EFHLNESGDPSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFHLNESGDPSSK 13 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 66450300.0 16374200.0 6312100.0 43764000.0 False True 15854409.983783942 8832554.44716666 32300895.508142445 1.0 0.5571039512792145 2.037344533235872 23.918380853270598 -6.826505695123108 1.3434835679516814 0.7627180313001268 2.0743996186853715 0.8987001272120114 0.1974383714987036 0.18516064681557903 0.6548402967503039 0.11542789599080742 0.26569785973608934 1.4910572023375844e-07 6.826505695123108 1.3116815873852445 up EFHLNESGDPSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFHLNESGDPSSK 13 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 266067300.0 1617300.0 262432000.0 2018000.0 False True 2453562.3404676807 215598959.20942536 1619141.4154791797 1.0 87.87180812708814 0.6599145205214352 21.226446497400776 -3.0561213059517804 1.1926155186839206e-11 9.999999695771324 69.87855124046634 0.0 42.255820338277196 0.0 0.26102210103865037 40.918950928734894 40.91894946535917 0.0008787770249423699 3.0561213059517804 59.878551544695014 EFHLNESGDPSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFHLNESGDPSSK 13 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 65126800.0 1596500.0 33755100.0 29775200.0 False True 2186769.193790261 32263688.068811372 22742910.999492977 1.0 14.754043618517276 10.400233853703314 21.060369526085946 -9.54276196967442 7.405779073039007 1.0000000184492328 12.577138736115192 0.9041008887728708 1.7774353935079226 0.0 0.0 1.7209944451408459 0.5736648064986768 2.865748213390729e-10 9.54276196967442 11.577138717665958 EFHLNESGDPSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFHLNESGDPSSK 13 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 18702760.0 16374200.0 1844230.0 484330.0 False True 13615872.800053308 1834294.7669390044 585601.163711098 1.0 0.13471738417913415 0.043008712868469606 23.698786128704874 -13.999999999999998 0.31704980078268585 9.718275566467442 0.024196342400831006 0.9996873729643718 0.007623146245432206 17.787245557058657 0.17943986950215793 102.69933971256715 0.03088984265463076 1.0000000000000041e-14 13.999999999999998 -9.694079224066611 EFHLNESGDPSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFHLNESGDPSSK 13 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 6140400.0 1617300.0 2461500.0 2061600.0 False True 2093626.7317491234 2324515.361167598 1686409.9538023372 1.0 1.110281659054658 0.8054969533147982 20.997572819493225 -6.808794919827773 1.4193988725312383 1.0601881821349353 0.8003003235912001 0.8567185979798967 0.04769472084256052 0.20843915244232092 0.8278619553953022 0.02642219100610137 0.06115950819036484 1.5531202427954206e-07 6.808794919827773 -0.2598878585437352 EFHLNESGDPSSK(ub)STEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFHLNESGDPSSKSTEIK 18 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 65618000.0 26942000.0 23153000.0 15523000.0 True False 35321222.90669917 19698662.649687156 13916828.86713035 1.0 0.5577004709525791 0.3940075603806692 25.074031957676063 -13.99999999999437 0.13809276689629704 3.1095016885748166 0.1866975740424053 0.99961064590819 0.005050662888947884 11.932554284971655 0.11628524931506574 6.790564420945355 0.18510538368230095 1.000000000012962e-14 13.99999999999437 -2.9228041145324113 EFHLNESGDPSSK(ub)STEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFHLNESGDPSSKSTEIK 18 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 118265000.0 52841000.0 29218000.0 36206000.0 True False 51163591.37870109 40884899.769857146 26722562.443282276 1.0 0.7991014443696213 0.52229645580366 25.608614200565388 -6.966630509083057 0.32886889561773275 1.0341715366298014 0.2781800618319493 0.9999429167565379 0.0014796321945718493 0.07741192755243632 0.012932076071231577 0.004055459089427041 0.0241656815953133 1.0798650637370639e-07 6.966630509083057 -0.7559914747978521 EFHLNESGDPSSK(ub)STEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFHLNESGDPSSKSTEIK 18 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 233117000.0 82589000.0 93719000.0 56809000.0 True False 125293551.06466666 76994112.22011085 45580676.24973075 1.0 0.6145097777647993 0.36379107992721504 26.900736919277765 -8.407224126542594 0.1765782083369547 1.3480107504368584 8.55817998786419e-08 0.9998337009524437 0.0033743678476363145 0.11962527341672013 0.04166044464253633 0.14278755595302964 0.13076405909687927 3.915397628635739e-09 8.407224126542594 -1.3480106648550585 down EFHLNESGDPSSK(ub)STEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFHLNESGDPSSKSTEIK 18 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 82097000.0 26942000.0 34036000.0 21119000.0 True False 36903185.48017365 32532176.977999303 16131127.159457972 1.0 0.8815547101069993 0.43712018216217324 25.137242019198954 -6.946345470642548 0.5976251106891803 1.0050331964839907 0.2909837175542766 0.998882347035686 0.008100416934121585 0.08498736216258455 0.042298323739576406 0.008333380805458443 0.03732048822525234 1.131499924617917e-07 6.946345470642548 -0.714049478929714 down EFHLNESGDPSSK(ub)STEIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFHLNESGDPSSKSTEIK 18 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 121398300.0 52841000.0 52967300.0 15590000.0 True False 43939632.75321035 52681954.64171413 18849796.919984356 1.0 1.1989621064337421 0.4289930465704026 25.389019475999664 -6.8380991493471095 1.2910304177273928 1.1058913371741987 0.40458232073753225 0.9211536644613149 0.0916352698917019 0.17103865910209062 0.5545655351219881 0.05567004938233551 0.1282066912296133 1.451780138623063e-07 6.8380991493471095 -0.7013090164366664 down EFHLNESGDPSSK(ub)STEIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFHLNESGDPSSKSTEIK 18 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 240416000.0 82589000.0 113070000.0 44757000.0 True False 106913088.5725768 106777555.10348177 36611685.24560111 1.0 0.9987323023691058 0.3424434345168848 26.671863241370215 -6.907320282232346 0.9137809986652876 1.0220823146089726 0.2623140759372935 0.9898705287544493 0.031167503032772607 0.10621738713504511 0.1485737274003064 0.02518381002809423 0.0682940477860803 1.2378833392148644e-07 6.907320282232346 -0.7597682386716791 down EFHTTGLAWSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFHTTGLAWSK 11 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0S3 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 22254000.0 4273800.0 7775200.0 10205000.0 False True 5602993.187538068 6615170.467492224 9149084.493272265 1.0 1.1806493861540643 1.6328923107779711 22.417766307776443 -6.955432210170917 0.4956338816692052 0.9905899656902379 1.8423131439992848 0.9995615000269995 0.005574104362345251 0.08137501113696838 0.027481699470893666 0.006591939124291517 0.03730164884200026 1.108071512808354e-07 6.955432210170917 0.8517231783090469 EFHTTGLAWSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFHTTGLAWSK 11 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0S3 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 17476600.0 4943900.0 1996700.0 10536000.0 False True 4786958.600654045 2793992.7226529447 7776305.526775172 1.0 0.5836676177377427 1.6244772882958902 22.190677898488314 -6.798174300942537 1.4635549267477936 0.7697520684106005 1.6381708988898747 0.8266963596271755 0.17806363430522343 0.22338706132925581 0.9448741953641746 0.09572578378453497 0.22285533265364213 1.5915698338350845e-07 6.798174300942537 0.8684188304792742 EFHTTGLAWSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFHTTGLAWSK 11 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0S3 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 20016600.0 4273800.0 4943800.0 10799000.0 False True 5853939.355102286 4725366.569039627 8248498.612386304 1.0 0.8072113977267298 1.4090509163196103 22.480976369299334 -6.820508865618046 1.3696322079107273 0.8961410278107235 1.4223379983840043 0.8855594039111506 0.08488789269060724 0.1928198812917387 0.710594380773801 0.04870228707994543 0.11223811366355554 1.5117888376304408e-07 6.820508865618046 0.5261969705732809 EFHTTGLAWSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFHTTGLAWSK 11 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0S3 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 12729800.0 4943900.0 4416100.0 3369800.0 False True 4111071.901905655 4392309.592772782 4074409.599805213 1.0 1.0684098204988246 0.991082057678571 21.97108317392259 -6.673190113531804 1.9258549973104593 1.0435446617088089 0.9913883594749361 0.2933540447216847 0.029037680941389435 0.45382839968897515 3.2479839306515843 0.012124843925495263 0.03226284923626342 2.1223152096560056e-07 6.673190113531804 -0.0521563022338728 EFHTTGLAWSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFHTTGLAWSK 11 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0S3 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 11751800.0 1981800.0 5707600.0 4062400.0 False True 2565479.1671182923 5389967.0426163655 3323084.883743995 1.0 2.10095919378317 1.2953076861180257 21.290796879547653 -10.045411017850638 4.405659772322844 0.9999598130624938 1.6981334392799974 0.5003000085506906 0.32890585099709496 37701584.68239893 17192794.275853712 14988.020557082767 0.1125932206422808 9.007182910896112e-11 10.045411017850638 0.6981736262175036 EFIGQQLILIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFIGQQLILIIK 12 0 Q9BPX3 Q9BPX3 NCAPG Condensin complex subunit 3 0 10012800.0 2024800.0 4508400.0 3479600.0 False True 3071769.632708194 3703840.79571002 2791855.534837145 1.0 1.2057677620976306 0.9088752962167069 21.550638594559206 -6.7202971751362774 1.758426911756549 1.125147628198019 0.9093359353375543 0.5138525665091046 0.08658459118406964 0.3547330436064951 2.1438170679531527 0.03909623874466844 0.09810517905968595 1.904157312370579e-07 6.7202971751362774 -0.21581169286046475 EFILNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFILNLK 7 0 E9PCB6;Q9BYT8;H0YAK4 E9PCB6 NLN Neurolysin, mitochondrial 0 9054300.0 2636700.0 2878300.0 3539300.0 False True 3456739.233839125 2448868.859525527 3173087.1873629102 1.0 0.708433206518087 0.9179423071027591 21.72098034439203 -9.858829182357674 5.554089265278351 1.0000000857513778 0.8131877575459301 0.5145848219246669 0.08553173215392991 116231646.44456834 15.97389942254496 127.45499466775979 0.02927978692644173 1.3841106733185862e-10 9.858829182357674 -0.1868123282054477 EFILNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFILNLK 7 0 E9PCB6;Q9BYT8;H0YAK4 E9PCB6 NLN Neurolysin, mitochondrial 0 9711000.0 3504800.0 1355000.0 4851200.0 False True 3393542.0424305247 1896058.5662316503 3580525.187119562 1.0 0.5587255270524523 1.0550996988842714 21.69436045603958 -6.672138692650925 1.9294394886551673 0.7188658334699967 1.0531302457989826 0.28874772268109217 0.1873499927442777 0.4562004021282046 3.2760980562042654 0.07810863899077042 0.20813319639549085 2.1274595298164586e-07 6.672138692650925 0.33426441232898596 EFILNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFILNLK 7 0 E9PCB6;Q9BYT8;H0YAK4 E9PCB6 NLN Neurolysin, mitochondrial 0 6054900.0 3504800.0 1333100.0 1217000.0 False True 2914396.4889659816 1325918.3257003687 1471469.0732277706 1.0 0.4549546812591722 0.5048966668738484 21.474765731473855 -10.354742416374767 8.992147511883768 1.0000008200002533 0.4799256750220948 0.993131391099074 0.020388730249562396 3.351709691095742e-07 2.4077516651840587e-08 0.019741334352868286 0.0065804343922392225 4.418324240960298e-11 10.354742416374767 -0.5200751449781584 EFK(ub)EEISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFKEEISR 8 1 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 210515900.0 2934900.0 122770000.0 84811000.0 True False 3847682.321612033 104453194.55371195 76035571.28455794 1.0 27.14704225112587 19.76139528398018 21.875558259296376 -9.655872204060872 9.004468440838961 0.9999975892854757 23.454218767553026 0.9249483994191904 3.0151777483071767 0.0 0.0 2.9194333012620675 0.9731444337540224 2.208654558357924e-10 9.655872204060872 22.454221178267552 EFK(ub)EEISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFKEEISR 8 1 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 215034900.0 2934900.0 101960000.0 110140000.0 True False 4020011.8426902834 97455070.06336832 84127200.404503 1.0 24.242483325160844 20.927102629678615 21.938768320819268 -9.95041256996709 13.630222860013694 1.0000000317138502 22.584792977515132 0.982613387550905 1.3534985011675136 0.0 0.0 1.3105193275911384 0.4368397628448733 1.1209530681916317e-10 9.95041256996709 21.584792945801283 EFLEK(ub)NYTDEAIETDDLTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFLEKNYTDEAIETDDLTIK 20 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 86079000.0 21245000.0 21821000.0 43013000.0 True False 20570589.103925057 30534239.09501173 31746604.93765947 1.0 1.4843638624421076 1.543300718189054 24.29407977480464 -11.74463154424442 0.34593965300068286 5.908796010631486e-10 1.5528881586584957 0.9995547578109857 0.005136238030487652 4.563839920747734 0.18054405308612942 3.3583810575955657 0.0178144500471945 1.8003977261089592e-12 11.74463154424442 1.5528881580676162 EFLEK(ub)NYTDEAIETDDLTIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFLEKNYTDEAIETDDLTIK 20 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 218777100.0 43079100.0 103900000.0 71798000.0 True False 65354144.20406931 85358233.2255948 57607093.82981864 1.0 1.306087536837181 0.88146045719671 25.961775386584076 -6.713284432301542 1.7833593112272887 1.1875423450887637 0.8823535118711978 0.4807038838081271 0.12891983463822645 0.3685357834545685 2.286705343929434 0.057483004250559425 0.14546271046474546 1.9351541591346565e-07 6.713284432301542 -0.30518883321756585 EFLEK(ub)NYTDEAIETDDLTIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFLEKNYTDEAIETDDLTIK 20 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 64561000.0 21245000.0 25743000.0 17573000.0 True False 17666158.813079864 25604317.34941455 21247433.05162831 1.0 1.4493426454684277 1.2027194636050087 24.074485050238916 -10.032592778939414 4.236615519689242 0.9999744466430323 1.326031054400278 0.6997156433924809 0.10068349271057205 11372394.155502068 5386120.587932218 2571.034135525875 0.03446663743431601 9.276992832571855e-11 10.032592778939414 0.32605660775724576 EFLEK(ub)NYTDEAIETDDLTIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFLEKNYTDEAIETDDLTIK 20 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 177264100.0 43079100.0 73128000.0 61057000.0 True False 55766744.16601354 69058362.51532163 49945252.4977247 1.0 1.238343094044363 0.8956099776784765 25.732901708676525 -6.719696881072352 1.760287965784613 1.145056069234608 0.8961510248216865 0.5110395140839707 0.10030019025318467 0.3559582511638618 2.1553919942499777 0.04524386778814033 0.11362461426424768 1.9067911120712612e-07 6.719696881072352 -0.24890504441292138 EFLESQEDYDPCWSLQEK(ub)YNSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFLESQEDYDPCWSLQEKYNSR 22 1 F8VWB3;E5RGL6;E5RHC5;Q8N6T3-3;Q8N6T3;Q8N6T3-2;E5RHT6;F8W1U7;F8VWH9;Q8N6T3-5 F8VWB3 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 1 26651800.0 7736500.0 10202000.0 8713300.0 True False 11736836.11391096 8381373.3914101785 6991112.435824938 1.0 0.7141084113355085 0.5956556237109587 23.484540219342463 -13.999999999999998 0.12093815289020017 2.3617155662357323 0.4089657360803124 0.9996883503882583 0.002996253276772034 11.960269641412786 0.10714705702246932 3.9095969569636875 0.16567872246640752 1.0000000000000041e-14 13.999999999999998 -1.9527498301554198 EFLHAQEEVKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFLHAQEEVKR 11 1 P43686 P43686 PSMC4 26S protease regulatory subunit 6B 0 3970160.0 640260.0 1947900.0 1382000.0 False True 839387.06028666 1657280.9128547306 1239003.8970800831 1.0 1.974394163627863 1.476081721651689 19.678976697722398 -10.196635706938677 4.822485280857275 0.9999031124355564 1.7252379426419688 0.7385077827528279 0.20343520256120068 0.0002119452766788991 3.5307503613100996e-05 0.19700136802302584 0.06565842929491404 6.358640810338382e-11 10.196635706938677 0.7253348302064124 EFLHAQEEVKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFLHAQEEVKR 11 1 P43686 P43686 PSMC4 26S protease regulatory subunit 6B 0 4363960.0 640260.0 1678400.0 2045300.0 False True 876981.424375917 1604242.7382734173 1562242.2642757408 1.0 1.8292778999453023 1.7813858091549357 19.74218675924529 -10.133055680679321 4.540605590787107 0.9999068625801183 1.8053318545702524 0.9973546158628077 0.019551864259825035 13654329.81443765 2.4955533247581054 13308.318703290244 0.006693123175105949 7.361127147997781e-11 10.133055680679321 0.8054249919901341 EFLLIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFLLIFR 7 0 Q96C19;H0Y4Y4 Q96C19 EFHD2 EF-hand domain-containing protein D2 0 7999800.0 2083200.0 3392400.0 2524200.0 False True 2731095.3737374963 2886267.1434716308 2263019.997836144 1.0 1.0568166792072817 0.8286125851178927 21.381048265271232 -6.840798229686957 1.2787351853549622 1.0302220839519651 0.8209898251619414 0.9258102557676142 0.026420330727446543 0.16786828130375325 0.5328666054500619 0.016199239733632964 0.03732715463915635 1.4427855043388818e-07 6.840798229686957 -0.20923225879002372 EFLLIFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFLLIFR 7 0 Q96C19;H0Y4Y4 Q96C19 EFHD2 EF-hand domain-containing protein D2 0 12324600.0 5109400.0 4177200.0 3038000.0 False True 4947204.893744164 5845177.743810224 2242256.661953584 1.0 1.181511150104489 0.45323707226861787 22.238182220805196 -6.840730802228539 1.2791139024109246 1.096548792617647 0.42895227018949567 0.9256846174594896 0.0843804894942414 0.1679478135172618 0.5334746652764346 0.0517228901045133 0.11917597481733516 1.4430095249424767e-07 6.840730802228539 -0.6675965224281513 down EFLLIFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFLLIFR 7 0 Q96C19;H0Y4Y4 Q96C19 EFHD2 EF-hand domain-containing protein D2 0 38873600.0 9869600.0 14659000.0 14345000.0 False True 14972904.764409687 12042986.91871024 11509704.462363135 1.0 0.8043186748463259 0.7687021752600395 23.83585079761072 -13.999999999999996 0.23960932951703462 2.2927757576547694 0.7528959334145233 0.9995243136504095 0.0022177644057747854 13.609653049422812 0.15492926827979828 8.416639617663442 0.01744358226089205 1.0000000000000082e-14 13.999999999999996 -1.539879824240246 EFLLIFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFLLIFR 7 0 Q96C19;H0Y4Y4 Q96C19 EFHD2 EF-hand domain-containing protein D2 0 12643800.0 2083200.0 5662400.0 4898200.0 False True 2853415.3363632113 5412216.4449472055 3741346.0415955773 1.0 1.896750317409202 1.3111817245519077 21.444258326794124 -10.103356271454853 4.556463042699507 0.9999525018204839 1.6039660209686986 0.5865087643426782 0.2390573770506863 166459889.9274338 10.183135589729597 86624.47116617675 0.0818356987078339 7.882132452620011e-11 10.103356271454853 0.6040135191482147 EFLLIFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFLLIFR 7 0 Q96C19;H0Y4Y4 Q96C19 EFHD2 EF-hand domain-containing protein D2 0 8704900.0 5109400.0 1962400.0 1633100.0 False True 4248692.484798792 1951828.1616940976 1974573.6593987478 1.0 0.45939501827384704 0.46474854710325286 22.018587496239473 -9.901375238952632 5.916117447302623 1.0000001702672843 0.4620717826882013 0.9999257214060912 0.002185568993792405 4.907696079297369e-09 9.114437433371143e-10 0.0021161687403819253 0.0007053893593976647 1.254945197861607e-10 9.901375238952632 -0.537928387579083 EFLLIFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFLLIFR 7 0 Q96C19;H0Y4Y4 Q96C19 EFHD2 EF-hand domain-containing protein D2 0 32330600.0 9869600.0 11507000.0 10954000.0 False True 12776391.75890133 10866625.334534055 8960484.397531437 1.0 0.8505238051238733 0.7013313748217415 23.60697711970317 -6.971148964244233 0.22909372012813684 1.0613679477249365 0.4862290190018553 0.9999900065753479 0.000385409567101857 0.07593167066937986 0.0076831005823746554 0.003859173651408373 0.014843965023979352 1.0686882532347181e-07 6.971148964244233 -0.5751389287230813 EFLPEGQDIGAFVAEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFLPEGQDIGAFVAEQK 17 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;H7C0V6 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 11803300.0 3652600.0 1727600.0 6423100.0 False True 3536650.2123321593 2417439.689314986 4740697.421130376 1.0 0.6835393788408788 1.340448485575348 21.753952107591687 -6.775704222866647 1.5525487062295034 0.8198125943994902 1.344973577915246 0.751917872180007 0.13360536324206113 0.2573058525660965 1.224684323380019 0.06780028404293256 0.16056811235943827 1.6760839877864956e-07 6.775704222866647 0.5251609835157559 EFLQPSSK(ub)ASLESTSDLGASGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFLQPSSKASLESTSDLGASGK 22 1 A0A0A0MR42;K7ENP4;Q8TEP8-1;Q8TEP8;H0Y966;K7EPA2 A0A0A0MR42 CEP192 Centrosomal protein of 192 kDa 1 3488100.0 1243600.0 0.0 2244500.0 True False 1630371.643039533 0.0 2012260.6707642921 1.0 0.0 1.2342343412038228 20.636769433446663 -6.691193610447267 1.8623622380509337 0.3737495284249197 1.2300055970217738 0.3758944871946952 0.42283026771117505 0.41412982227861006 2.7858288638408464 0.18157371252141272 0.4720877068681616 2.0361341575127403e-07 6.691193610447267 0.8562560685968541 EFLQPSSK(ub)ASLESTSDLGASGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFLQPSSKASLESTSDLGASGK 22 1 A0A0A0MR42;K7ENP4;Q8TEP8-1;Q8TEP8;H0Y966;K7EPA2 A0A0A0MR42 CEP192 Centrosomal protein of 192 kDa 1 6795100.0 1243600.0 2729100.0 2822400.0 True False 1703392.5270263508 2608519.338073154 2155807.2491526194 1.0 1.531367137454162 1.2655962820948021 20.699979494969554 -10.036244261214668 4.374127242099502 0.9999765245109752 1.3984817096130189 0.7498357125224584 0.10850049755814827 14119932.665203627 8106268.907785988 3013.1481093995017 0.03714260640000436 9.199320268019957e-11 10.036244261214668 0.3985051851020437 EFLSAK(ub)EETPGAGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFLSAKEETPGAGQK 15 1 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 96941900.0 8512700.0 53271300.0 35157900.0 True False 11160232.137104077 45323429.68990103 31520097.766390644 1.0 4.061154744193504 2.824322772068222 23.4118637003003 -9.103300057519693 12.334334969527344 1.0000195867616768 3.442754481113347 0.838730867289875 0.5049345385010475 0.0 5.75728239175116e-17 0.488900779368957 0.1629669215996212 7.883152761139319e-10 9.103300057519693 2.44273489435167 EFLSAK(ub)EETPGAGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFLSAKEETPGAGQK 15 1 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 130688400.0 35033200.0 37275300.0 58379900.0 True False 33921090.242204174 52159521.678121574 43088452.83054115 1.0 1.5376723243766908 1.2702555408119243 25.01567920385747 -10.031410972343929 4.362492991748478 0.9999768886078266 1.4039639324450872 0.7526351861286775 0.10917244495957669 24816811.237399753 0.16813418347881467 5992.032141906276 0.03885821209722376 9.302271859727653e-11 10.031410972343929 0.4039870438372606 EFLSAK(ub)EETPGAGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFLSAKEETPGAGQK 15 1 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 276052000.0 75798000.0 84596000.0 115658000.0 True False 114991107.57606453 69499182.84843525 92798145.60529786 1.0 0.6043874549383117 0.8070027984025946 26.77694705894729 -10.077076653077206 4.790741383529634 1.0000111509104002 0.7056951266665421 0.7377478882969308 0.0827173676045006 21180868.317127828 44552861.47441033 1549.6802538611898 0.028316353057108216 8.373814710582479e-11 10.077076653077206 -0.29431602424385805 EFLSAK(ub)EETPGAGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFLSAKEETPGAGQK 15 1 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 77752200.0 8512700.0 25698800.0 43540700.0 True False 11660075.237067558 24563342.041432813 33257283.40886458 1.0 2.1066195150564355 2.852235747428041 23.475073761823193 -8.18837016574829 0.17132011931819485 3.638000814285379e-10 4.04198225485899 0.9998817030071514 0.008276365826403089 0.08805320243356582 0.03521883160409933 0.3454804576867789 0.3752235806935411 6.480818132286732e-09 8.18837016574829 4.04198225449519 EFLSAK(ub)EETPGAGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFLSAKEETPGAGQK 15 1 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 108590300.0 35033200.0 42518500.0 31038600.0 True False 29131658.033908684 42289444.40123858 37528627.75372849 1.0 1.451666237191666 1.288242080490094 24.796084479291746 -10.035862726157001 4.876409723839655 0.9999926443761411 1.3699541588460473 0.8723325914227757 0.06671763261175465 46146325.44699833 1.628614769590456 3811.2336838306815 0.022839220225303866 9.207405577698015e-11 10.035862726157001 0.3699615144699062 EFLSAK(ub)EETPGAGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFLSAKEETPGAGQK 15 1 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 218568000.0 75798000.0 75858000.0 66912000.0 True False 98122005.20195386 71636435.61545883 54734702.57509804 1.0 0.7300751291009325 0.5578229110019057 26.54807338103974 -8.978194234984787 0.09606041785609774 1.639229101270211 1.5319030157246461e-10 0.9999706803557024 0.000985362011194785 0.45844486181651156 0.030356479989783993 0.28831136183926553 0.212073891273025 1.0514914968743174e-09 8.978194234984787 -1.6392291011170206 EFLSAK(ub)EETPGAGQK(ub)QELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFLSAKEETPGAGQKQELR 19 2 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 2 19997300.0 5344300.0 2188700.0 12464300.0 True False 7006429.05427482 1862154.4914857796 11174613.802008174 1.0 0.26577797007016385 1.594908578313546 22.740247906810627 -6.756755889153487 1.6246258656148123 0.5717868638908761 1.5990060639978958 0.6775389080868963 0.30869134670684734 0.28843469832084756 1.499655550136583 0.14996981027733086 0.3615730418724382 1.7508305294195271e-07 6.756755889153487 1.0272192001070197 EFLSAK(ub)EETPGAGQK(ub)QELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFLSAKEETPGAGQKQELR 19 2 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 2 89425600.0 6095600.0 45680000.0 37650000.0 True False 9247470.848052183 37528047.10053099 30208460.997418787 1.0 4.058195772353866 3.266672746936171 23.140627416694333 -9.128925990475118 10.337840300780481 1.0000000021415718 3.6624339038922247 0.9378335123088016 0.3231379219920095 0.0 0.0 0.31287694759991197 0.1042923158666373 7.431457689765004e-10 9.128925990475118 2.662433901750653 EFLSAK(ub)EETPGAGQK(ub)QELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFLSAKEETPGAGQKQELR 19 2 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 2 28011600.0 5344300.0 1129700.0 21537600.0 True False 7320232.134277032 1079786.118581673 16450862.460795553 1.0 0.14750708703970844 2.2473143144961605 22.803457968333518 -6.7965015546722505 1.4702432716939802 0.5275301285100247 2.2738249630286496 0.8216981782829702 0.36410426068299606 0.22579863392522664 0.9639456970756802 0.19486216891962094 0.4541595111138784 1.5977118096153497e-07 6.7965015546722505 1.7462948345186249 EFLSAK(ub)EETPGAGQK(ub)QELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFLSAKEETPGAGQKQELR 19 2 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 2 78028600.0 6095600.0 30361000.0 41572000.0 True False 7890874.36223951 28671383.660536073 34006322.56474132 1.0 3.6334862708926523 4.3095759739216 22.911753738786782 -9.620509274162025 0.38275678457084816 3.1088673424131737e-19 4.418112224928209 0.9984742261484865 0.05576866706897399 0.9561872313427817 0.16084211616175417 1.418219606408085 0.1793361450249239 2.396021583243189e-10 9.620509274162025 4.418112224928209 EFMK(ub)DTDSINLYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFMKDTDSINLYK 13 1 O14980 O14980 XPO1 Exportin-1 1 28466800.0 2678600.0 6685100.0 19103100.0 True False 4063632.031890635 5492091.674075295 15327363.911813838 1.0 1.3515228817408595 3.7718385403814896 21.954338339101277 -6.932998226449617 0.7217633475951316 0.9669739241262686 4.308900119253876 0.997095260319813 0.06640955612779446 0.09111094070100278 0.07027247986274437 0.06161936010949022 0.21550082781710986 1.166814382030252e-07 6.932998226449617 3.341926195127607 up EFMK(ub)DTDSINLYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFMKDTDSINLYK 13 1 O14980 O14980 XPO1 Exportin-1 1 31728100.0 2678600.0 6837100.0 22212400.0 True False 3467500.503099733 6456609.374706078 18169971.118470646 1.0 1.8620355985339483 5.240077428172773 21.725464661193726 -6.94534672783976 0.6077885773684205 0.9625096000197547 6.314854769514415 0.9987836555690988 0.06381530034134068 0.08540983753719816 0.04412254391396835 0.06500330172060224 0.2846255892942567 1.1341050183132919e-07 6.94534672783976 5.352345169494661 EFMWALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFMWALK 7 0 P58546;C9JL85 P58546 MTPN Myotrophin 0 11182000.0 3143000.0 2872800.0 5166200.0 False True 4120503.436855298 2444189.4380866955 4631651.181689673 1.0 0.5931773812454484 1.1240498285385425 21.97438918379171 -6.701887143418889 1.8236771938008256 0.7478627226832333 1.122555742507645 0.42682758564923684 0.17166424371972777 0.391567686163016 2.532991096089885 0.07505121062603251 0.19259667708793063 1.986611094783573e-07 6.701887143418889 0.3746930198244116 EFMWALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFMWALK 7 0 P58546;C9JL85 P58546 MTPN Myotrophin 0 6995300.0 2612400.0 1018800.0 3364100.0 False True 2529470.791955464 1425612.152971814 2482941.289163281 1.0 0.5636009545971916 0.9816050444463871 21.270404149625993 -10.688414697776516 9.7679177065415 1.0002057051378557 0.7726030008903632 0.28294387049565317 0.17064945508783705 0.0007651339495179931 2.4406952825588964e-05 0.16537655522905426 0.05507687479954694 2.04920450622225e-11 10.688414697776516 -0.22760270424749252 EFMWALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFMWALK 7 0 P58546;C9JL85 P58546 MTPN Myotrophin 0 11078400.0 3143000.0 3559100.0 4376300.0 False True 4305052.036381326 3401847.1936301948 3342708.0727276755 1.0 0.790198855874845 0.7764617116074252 22.037599245314603 -13.999999999999998 0.3874414572867706 4.263479893625911 0.7754088713073625 0.9998192349396979 0.001375305077440954 25.00299740554157 0.20375203733579628 68.2642220028507 0.0036423394187465427 1.0000000000000041e-14 13.999999999999998 -3.488071022318549 EFMWALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFMWALK 7 0 P58546;C9JL85 P58546 MTPN Myotrophin 0 4654700.0 2612400.0 1098000.0 944300.0 False True 2172326.3489428037 1092084.8560640642 1141748.7640501102 1.0 0.5027259631572135 0.5255880473970957 21.05080942506027 -10.18641561574643 5.359028426146487 1.0000212067493253 0.5141570052770582 0.9983420152580366 0.009333406807753245 2.364949057264189e-06 3.590366741634156e-07 0.009037426084764716 0.0030123440940956103 6.510050900941996e-11 10.18641561574643 -0.48586420147226705 EFNAEVHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFNAEVHR 8 0 P46777;A0A2R8Y6J3 P46777 RPL5 60S ribosomal protein L5 0 8032800.0 4878000.0 2034700.0 1120100.0 False True 4056273.1320406455 2023738.6672436711 1354307.7312427512 1.0 0.49891577844156687 0.33387981705300523 21.95172336983445 -13.999999999999998 0.15524002793501276 3.444585265794435 0.16280834450217432 0.9995497026383086 0.006010469295628981 11.981325115961953 0.12433332018834341 8.824355819096215 0.15503822585511595 1.0000000000000041e-14 13.999999999999998 -3.2817769212922605 EFNEDGALAVLQQFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFNEDGALAVLQQFK 15 0 O60506;O60506-2;O60506-3;O60506-4;F6UXX1 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 6120240.0 920840.0 3481700.0 1717700.0 False True 1207230.1574272441 2962243.9315603063 1539968.8813418685 1.0 2.453752429340576 1.2756216135485976 20.203269320251124 -6.59401867283588 2.2142163827386967 1.9814580616295048 1.2792638800853997 0.003622209478585936 0.6293204171834621 0.657754737766868 6.08586826067335 0.23676563158847067 0.7005527099792219 2.546720751951369e-07 6.59401867283588 -0.7021941815441051 EFNEDGALAVLQQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFNEDGALAVLQQFK 15 0 O60506;O60506-2;O60506-3;O60506-4;F6UXX1 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 7304840.0 920840.0 2569500.0 3814500.0 False True 1261299.432765312 2455970.9937997763 2913593.6620934885 1.0 1.9471752147031647 2.309993635457074 20.266479381774015 -10.149376656394296 0.2250308106745445 7.725593796546771e-18 2.5601815458686437 0.9992511639677305 0.015112360041266076 1.6827041735698802 0.10579957966375743 1.2003817399027321 0.18765604094192626 7.089626297333029e-11 10.149376656394296 2.5601815458686437 EFNEDGALAVLQQFK(ub)DSDLSHVQNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFNEDGALAVLQQFKDSDLSHVQNK 25 1 O60506;O60506-2;O60506-3;O60506-4;F6UXX1 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 6343800.0 2252500.0 2167200.0 1924100.0 True False 1873053.5526694448 2155524.8634444834 2326420.4139667656 1.0 1.150807920239368 1.242046929545175 20.836960717739167 -13.410292119040323 0.05272723954303902 3.656076268938441e-20 1.7464397422619398 0.9999746801642513 0.0005021876808879785 10.294316713992078 0.05153737253462682 1.5682157496206306 0.45161740690689867 3.887835499558844e-14 13.410292119040323 1.7464397422619398 EFNFEK(ub)WNAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFNFEKWNAR 10 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 1 7627600.0 2772900.0 2401400.0 2453300.0 True False 2684875.807308721 3360291.543135564 1810707.1325775934 1.0 1.251563120345544 0.6744100146638138 21.356423925198293 -6.78824705109162 1.5034624670089038 1.1409183293175826 0.6685747628488533 0.7955658797095146 0.10682665359090852 0.2379677075960445 1.0626920232314805 0.05593514188427133 0.13111958454225733 1.6283694611217785e-07 6.78824705109162 -0.4723435664687293 EFNFEK(ub)WNAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFNFEKWNAR 10 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 1 31568900.0 4369700.0 4585200.0 22614000.0 True False 5656662.78966435 4330029.589285265 18498484.0392346 1.0 0.765474229292391 3.2702115588424965 22.43151973956708 -6.8839780809791264 1.0574085094817072 0.8453542512769257 3.461804906078756 0.9767533548204068 0.17221797414134832 0.12416270411513092 0.2515104532110081 0.12498157012711149 0.3055239944169821 1.3062368127766394e-07 6.8839780809791264 2.61645065480183 up EFNK(ub)GPWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFNKGPWK 8 1 Q16531;F5GY55;F5H2L3 Q16531 DDB1 DNA damage-binding protein 1 1 18031400.0 5592100.0 8201700.0 4237600.0 True False 4650078.922034539 8157515.81419001 5123662.567551363 1.0 1.7542747017766462 1.1018442167234481 22.148823771450566 -10.224489815502245 4.287211430928924 0.9997988425719108 1.428059459265094 0.3646581399080989 0.2663536302216431 189174138.77505654 104933472.35464665 404543.16303200054 0.0974754480393586 5.963623047673728e-11 10.224489815502245 0.42826061669318316 EFNK(ub)GPWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFNKGPWK 8 1 Q16531;F5GY55;F5H2L3 Q16531 DDB1 DNA damage-binding protein 1 1 29391500.0 8569700.0 13217000.0 7604800.0 True False 11093645.584041594 12481462.331323244 6220804.43183742 1.0 1.125100151863338 0.5607538463988933 23.403230204800675 -6.848558215272072 1.2420456685741965 1.0666839340517307 0.5388152415509501 0.9381792722008143 0.06017021874075526 0.15904965306271415 0.4728892789052849 0.03792173780965065 0.0876752875122763 1.4172347246056161e-07 6.848558215272072 -0.5278686925007806 EFNK(ub)YDTDGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFNKYDTDGSK 11 1 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 9805300.0 1305600.0 2200300.0 6299400.0 True False 1980690.652145306 1807639.273977634 5054320.828874898 1.0 0.9126307896792271 2.5517971841794234 20.917572144420017 -6.894313344479146 0.996499564157462 0.9208150434295262 2.7053058159540124 0.9835190969141985 0.09666381204537114 0.11571383535217108 0.20195466852992836 0.07345949533509286 0.1862240393515686 1.275518187396139e-07 6.894313344479146 1.784490772524486 up EFNK(ub)YDTDGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFNKYDTDGSK 11 1 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 7333900.0 1305600.0 1346700.0 4681600.0 True False 1690124.937223555 1271754.9611555582 3829596.837272516 1.0 0.7524621009643985 2.265866122041586 20.688698466512466 -6.864929630430282 1.160496086504363 0.8634783827267225 2.3463911881311232 0.9593601852098462 0.13362186790974667 0.14181387951732513 0.36014542514360937 0.08960366566659528 0.21047631282308943 1.364804260531677e-07 6.864929630430282 1.4829128054044007 up EFNKYDTDGSK(ub)WIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFNKYDTDGSKWIK 14 2 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 67104000.0 27821000.0 25205000.0 14078000.0 True False 42206490.987541735 20706970.822436146 11295477.129393393 1.0 0.4906110491049424 0.26762417024261803 25.330961554030488 -11.115294634724908 0.1578193883215233 2.0420800277036535 1.762059527543194e-18 0.9996039114310142 0.0061002926738075326 3.400624138637339 0.09273233033042444 1.4624124315472566 0.193115344429122 7.668410713609812e-12 11.115294634724908 -2.0420800277036535 EFNKYDTDGSK(ub)WIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFNKYDTDGSKWIK 14 2 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 23329200.0 8889200.0 11720000.0 2720000.0 True False 12175777.461597487 11202171.647142792 2077592.0201584192 1.0 0.9200374828198481 0.1706332122701128 23.53751056006579 -6.9272765684939905 0.7688195309842565 1.01262106359865 0.026937864479769938 0.9959753495427727 0.023698000648406003 0.0940768763253446 0.08479066118390997 0.021250011906954788 0.0688515585937225 1.1822884080902832e-07 6.9272765684939905 -0.9856831991188799 down EFNKYDTDGSK(ub)WIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFNKYDTDGSKWIK 14 2 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 40755300.0 15239000.0 23066000.0 2450300.0 True False 12671903.702166345 22941738.879757456 2962646.401092858 1.0 1.8104413842598421 0.23379647373633167 23.59512994128408 -6.767019544100089 1.5862124458544933 1.4666226075202318 0.22598071185379587 0.7189020292876172 0.34130613889179834 0.2712762340597921 1.346622254681251 0.16966203781235623 0.40492305504494525 1.7099383627920733e-07 6.767019544100089 -1.2406418956664358 EFPGLAGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFPGLAGVK 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 23885800.0 1847100.0 13358000.0 8680700.0 False True 2421565.9873418426 11365038.46907618 7782504.435154194 1.0 4.693259869226857 3.213831246323815 21.20750888604184 -9.580549335850261 10.225192232925147 1.0000000000000495 3.953545556591538 0.8416268573134649 0.603974206163474 0.0 0.0 0.5847955105024949 0.19493183683416493 2.6269430888004736e-10 9.580549335850261 2.9535455565914885 EFPGLAGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFPGLAGVK 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 25076700.0 1847100.0 13658000.0 9571600.0 False True 2530022.7860006164 13054544.399033796 7310985.213289817 1.0 5.159852500644876 2.88969145011014 21.27071894756473 -9.681591276358182 7.089269930155427 0.9999999999381988 4.0247719752543585 0.7030056757234002 0.9267893679599337 1.6573769548379727e-08 3.772378708725935e-09 0.8973599468870707 0.29911998229569026 2.081654854548051e-10 9.681591276358182 3.0247719753161597 EFQALIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFQALIK 7 0 H0Y7V4;A0A075B6F3;Q96JB1-2;Q96JB1 H0Y7V4 DNAH8 Dynein heavy chain 8, axonemal 0 25927800.0 9397200.0 9450200.0 7080400.0 False True 14256239.427343646 7763737.975250397 5680955.836550434 1.0 0.5445852684235543 0.39848908721708826 23.76509013582351 -13.999999999999998 0.15905816887765306 3.2384468288286365 0.25336633803299285 0.9995388767002077 0.0055007234010237644 12.003523613224377 0.12600068933199254 8.290064098279 0.13211160091594432 1.0000000000000041e-14 13.999999999999998 -2.9850804907956436 EFQALIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFQALIK 7 0 H0Y7V4;A0A075B6F3;Q96JB1-2;Q96JB1 H0Y7V4 DNAH8 Dynein heavy chain 8, axonemal 0 26866600.0 9397200.0 8485600.0 8983800.0 False True 12164860.646505198 8013368.900558106 7348840.581572297 1.0 0.6587308423348228 0.6041039675767697 23.53621645791596 -13.999999999999998 0.25786215979657257 3.4706560483976303 0.5837255588125609 0.9995580018420841 0.0036828704539412418 14.323628865937906 0.16068729949727514 18.417001869211063 0.024154047220063167 1.0000000000000041e-14 13.999999999999998 -2.8869304895850694 EFQTYVK(ub)SQDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFQTYVKSQDK 11 1 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 1 2788810.0 577740.0 871270.0 1339800.0 True False 559399.9599388869 1219172.654613026 988866.1868615593 1.0 2.1794292848112065 1.7677265957787887 19.093520624933127 -10.116166635392698 4.665785824242043 0.9999282099938273 1.9735779403109588 0.8817424274343811 0.16807691903204994 88582271.66972668 10.046954436888827 69675.63541271257 0.061509854070258406 7.653029098351308e-11 10.116166635392698 0.9736497303171315 EFQTYVK(ub)SQDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFQTYVKSQDK 11 1 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 1 11009900.0 3098900.0 3808800.0 4102200.0 True False 4701257.859936493 3129089.881709774 3291398.3719418715 1.0 0.6655856740757553 0.7001101556225493 22.16461538260399 -9.779145303412996 6.226289743469899 1.0000000079410176 0.6828479151379754 0.991190773511633 0.014094560571713051 1.5596159890855723e-09 2.939479908062623e-10 0.013646999997823614 0.004548999863703835 1.662856209713492e-10 9.779145303412996 -0.31715209280304224 EFQTYVK(ub)SQDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFQTYVKSQDK 11 1 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 1 3385180.0 577740.0 1934300.0 873140.0 True False 480416.40822164057 1923879.5419715103 1055709.5370567765 1.0 4.004608312803351 2.1974885099464045 18.873925900367404 -9.913683829164636 6.240300714030749 0.9999996506165184 3.101048411375152 0.6431554919146496 0.7377535701807222 3.586151487869122e-06 6.277106920245565e-07 0.7143269504413764 0.23810894090943932 1.2198773589603836e-10 9.913683829164636 2.101048760758634 EFQTYVK(ub)SQDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFQTYVKSQDK 11 1 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 1 10750300.0 3098900.0 2090900.0 5560500.0 True False 4011587.138451342 1974539.576951181 4548546.055548072 1.0 0.49220907057585306 1.1338519888923617 21.93574170469644 -6.695812891398044 1.8460496102743718 0.6833867670028538 1.1317830825414756 0.3975767033806662 0.2145149885752634 0.40432078843728314 2.675827803806589 0.09281377783731172 0.23991198500765684 2.0145920166020108e-07 6.695812891398044 0.4483963155386218 EFSAGTVYPETNKTK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFSAGTVYPETNKTK 15 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 22207800.0 11161000.0 7185900.0 3860900.0 True False 14632179.083277749 6113791.730418812 3461411.104367946 1.0 0.41783193710401634 0.23656155960555372 23.802641301667204 -13.99999999999979 0.16336477296534022 3.888424557209687 0.06481785409244196 0.9995279254332202 0.00707617315468722 12.033805724079127 0.127833775474628 11.011986997317994 0.1572168250408882 1.0000000000004826e-14 13.99999999999979 -3.823606703117245 EFSAGTVYPETNKTK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFSAGTVYPETNKTK 15 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 35261900.0 13594000.0 5361900.0 16306000.0 True False 13162465.910979398 7502934.631939109 12034969.430485565 1.0 0.5700250000784867 0.9143400265482673 23.64992645908079 -9.900209990962372 6.551733968153724 1.0000000160613043 0.7421825133133667 0.42777666365975964 0.14056602093734508 3.298128878008426e-08 5.5718883193140496e-09 0.13610247264555977 0.04536748817774286 1.2583168407267716e-10 9.900209990962372 -0.2578175027479376 EFSAGTVYPETNKTK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFSAGTVYPETNKTK 15 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 22776100.0 11161000.0 5127300.0 6487800.0 True False 15287523.314684048 4900758.932286278 4955515.26043522 1.0 0.3205724584294813 0.3241542242277612 23.865851363190096 -10.502001182298644 6.226335345992403 1.000537389592663 0.3223633413286212 0.9999790463580155 0.001462249763989771 1.0915998972263522e-05 8.730904467815376e-07 0.001416855457767611 0.0004719390819939964 3.14773974486166e-11 10.502001182298644 -0.6781740482640418 EFSAGTVYPETNKTK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFSAGTVYPETNKTK 15 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 38434700.0 13594000.0 15545000.0 9295700.0 True False 11304013.316310085 15461255.99955909 11239387.89153935 1.0 1.3677669662022331 0.9942829663268806 23.430331734515065 -6.649660830863909 2.0093493524473134 1.2386999890120836 0.9958391745488862 0.19286974261959922 0.15697828561930077 0.509334301939666 3.9411929047804577 0.06336159806007335 0.1739133885852949 2.240470186090309e-07 6.649660830863909 -0.2428608144631974 EFSFEAWNAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFSFEAWNAK 10 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 0 12799400.0 3349200.0 4405400.0 5044800.0 False True 4390833.633698932 3748131.492114707 4522812.489138646 1.0 0.8536263964429007 1.0300578128095763 22.06606344189282 -6.6864281066176705 1.8789239867122023 0.9079287578045623 1.0294262358601112 0.353841471124563 0.06195117605768038 0.42439311524713946 2.9019322481189427 0.02640357904468969 0.06907261162698242 2.0585996442199088e-07 6.6864281066176705 0.12149747805554889 EFSFEAWNAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFSFEAWNAK 10 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 0 6799100.0 3370400.0 0.0 3428700.0 False True 3263408.496863689 0.0 2530620.6112048244 1.0 0.0 0.7754532151389834 21.637948157278885 -10.876680373243437 9.429795594119843 1.0420791069005586 0.3877266075694917 0.45391729486078103 0.3165774494151961 0.16315481549169217 0.002133679324897728 0.17857256933829585 0.10217493244748965 1.3283717368940331e-11 10.876680373243437 -0.654352499331067 EFSFEAWNAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFSFEAWNAK 10 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 0 10465800.0 3349200.0 3473400.0 3643200.0 False True 4587489.7487267945 3319933.703002193 2782751.1940592467 1.0 0.7236928875805342 0.6065956212396044 22.12927350341571 -13.999999999651035 0.11741061100293965 2.3198567572216575 0.41301012117154406 0.9997057359237187 0.0028292661916253163 11.974441625483607 0.1051114022677611 3.7010131433649476 0.17177470937783965 1.0000000008035224e-14 13.999999999651035 -1.9068466360501135 EFSFEAWNAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFSFEAWNAK 10 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 0 6992000.0 3370400.0 1721900.0 1899700.0 False True 2802636.9340364523 1712623.7829296114 2296918.4867796227 1.0 0.6110758629242186 0.8195562039752053 21.41835343271316 -10.054239404636112 5.018266661233272 1.000005108391141 0.7153160334480666 0.7131540043023472 0.08511174283509768 4.864449992096905e-06 9.168173497240992e-07 0.0824105694777653 0.027469696879767826 8.82593237172876e-11 10.054239404636112 -0.2846890749430744 EFSGNPIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFSGNPIK 8 0 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 9820380.0 2528600.0 908680.0 6383100.0 False True 2448330.977085662 1271520.6627035995 4711174.621104649 1.0 0.5193418188161542 1.9242392736918816 21.22336717095089 -6.8143722318937545 1.3961828173762825 0.7393677744659839 1.9513291506180288 0.8709140777876304 0.20946285983090734 0.20089758203558167 0.7709805721554656 0.11794079718344568 0.27230785005738034 1.5333022328344692e-07 6.8143722318937545 1.211961376152045 EFSHIAFLTIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFSHIAFLTIK 11 0 X6R5C5;X6R8A1;P10619-2;P10619 X6R5C5 CTSA Carboxypeptidase;Lysosomal protective protein;Lysosomal protective protein 32 kDa chain;Lysosomal protective protein 20 kDa chain 0 13741850.0 3778350.0 7807600.0 2155900.0 False True 4953453.43959345 6642736.51378643 1932828.1488530803 1.0 1.3410313824069426 0.39019810571020835 22.240003260781112 -6.809699058905914 1.4156738431099516 1.185929174682911 0.37365944586039396 0.8590603864947867 0.14765666859313903 0.20721812563431427 0.8185442286333209 0.08201135091408489 0.1897460556541217 1.5498902316699643e-07 6.809699058905914 -0.8122697288225171 down EFSHIAFLTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFSHIAFLTIK 11 0 X6R5C5;X6R8A1;P10619-2;P10619 X6R5C5 CTSA Carboxypeptidase;Lysosomal protective protein;Lysosomal protective protein 32 kDa chain;Lysosomal protective protein 20 kDa chain 0 15667600.0 6455300.0 5404700.0 3807600.0 False True 6250380.034952564 7562824.89513817 2810275.3344484796 1.0 1.2099784097680975 0.4496167143010861 22.575512480358583 -6.833065744845915 1.3142343712526776 1.1119800795842083 0.4278556191659341 0.9118549125948958 0.09518901554005721 0.17705781832777304 0.5970167720280389 0.05685089842970151 0.13082632583703888 1.468703923857862e-07 6.833065744845915 -0.6841244604182741 down EFSHIAFLTIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFSHIAFLTIK 11 0 X6R5C5;X6R8A1;P10619-2;P10619 X6R5C5 CTSA Carboxypeptidase;Lysosomal protective protein;Lysosomal protective protein 32 kDa chain;Lysosomal protective protein 20 kDa chain 0 25247700.0 7549000.0 9087200.0 8611500.0 False True 11452384.905824853 7465518.161382342 6909433.250445458 1.0 0.6518745416585909 0.6033182876111 23.449144728344027 -13.999999999999998 0.27751787353017493 3.798770854746818 0.5883396235262148 0.9995996979278953 0.0035346966554076066 15.265427212914485 0.16684284065987345 24.212977010889173 0.019436489483794707 1.0000000000000041e-14 13.999999999999998 -3.2104312312206034 EFSHIAFLTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFSHIAFLTIK 11 0 X6R5C5;X6R8A1;P10619-2;P10619 X6R5C5 CTSA Carboxypeptidase;Lysosomal protective protein;Lysosomal protective protein 32 kDa chain;Lysosomal protective protein 20 kDa chain 0 33527450.0 3778350.0 13606000.0 16143100.0 False True 5175308.101069482 13004841.930974793 12330432.257580655 1.0 2.512863326588678 2.3825503751230888 22.303213322304003 -10.158613189357254 4.961115906674078 0.9999030693230074 2.4477068508592175 0.993959901287008 0.053200039672675226 18623365.714601893 3.8725032395240717 20621.3406328819 0.018211788616308296 6.94043690832922e-11 10.158613189357254 1.44780378153621 EFSHIAFLTIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFSHIAFLTIK 11 0 X6R5C5;X6R8A1;P10619-2;P10619 X6R5C5 CTSA Carboxypeptidase;Lysosomal protective protein;Lysosomal protective protein 32 kDa chain;Lysosomal protective protein 20 kDa chain 0 11207500.0 6455300.0 2737400.0 2014800.0 False True 5367867.968278386 2722653.082868642 2436085.364617347 1.0 0.5072131242717335 0.453827362933195 22.35591775579286 -13.999999999999998 0.31387923539508245 5.87311387513367 0.44248950698176 0.9996804885189234 0.004394590955845822 17.55059708564152 0.17840997849188567 55.977307502427244 0.018210907378202433 1.0000000000000041e-14 13.999999999999998 -5.43062436815191 EFSHIAFLTIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFSHIAFLTIK 11 0 X6R5C5;X6R8A1;P10619-2;P10619 X6R5C5 CTSA Carboxypeptidase;Lysosomal protective protein;Lysosomal protective protein 32 kDa chain;Lysosomal protective protein 20 kDa chain 0 30838300.0 7549000.0 16062900.0 7226400.0 False True 9772329.313036634 15168985.494576098 5911269.3491255455 1.0 1.5522384693217546 0.6048987052902222 23.220271050436477 -6.748708411808662 1.6548893898914336 1.3252270295685025 0.6032292173873794 0.6433039860218461 0.23203937599964444 0.3022944592022018 1.6285002510362183 0.11078886686549817 0.26930329472136394 1.7835758701830375e-07 6.748708411808662 -0.721997812181123 EFSIDVGYER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFSIDVGYER 10 0 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 0 25200900.0 5573900.0 12596000.0 7031000.0 False True 7215523.427995082 11895021.527226131 5751430.144152236 1.0 1.6485320359539464 0.7970911884004982 22.7826726237194 -6.703129351538843 1.8200963525883462 1.4014795610395032 0.7995016073618093 0.43228706230218494 0.27360043188494776 0.3890359286315905 2.5077721955746672 0.11983692603057587 0.30695986289189986 1.9809369298818863e-07 6.703129351538843 -0.6019779536776939 EFSIYMTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFSIYMTK 8 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 35483100.0 9720100.0 11919000.0 13844000.0 False True 12743145.22958229 10140731.659898106 12411555.6810251 1.0 0.7957793368278603 0.973978986931152 23.603218067951325 -10.215460356969785 6.469699801683344 1.0000009669810892 0.8848791619120743 0.3575158728329305 0.07274970251592763 1.0147181427352982e-06 1.2297854448356433e-07 0.07044018855360461 0.02347986552381092 6.088911236896537e-11 10.215460356969785 -0.11512180506901493 EFSIYMTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFSIYMTK 8 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 28240700.0 7398500.0 3123200.0 17719000.0 False True 7163638.667234156 4370310.047272841 13077862.341394195 1.0 0.6100684652427054 1.8255893337014848 22.772261139180692 -6.820379501486266 1.370167025154121 0.7899046251744285 1.8523546681352256 0.8852594528658179 0.1716524046366652 0.19299490097652566 0.7118265325831739 0.09844249840563765 0.22687863131467947 1.5122392241516834e-07 6.820379501486266 1.0624500429607973 EFSIYMTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFSIYMTK 8 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 31436900.0 9720100.0 8862800.0 12854000.0 False True 13313883.64582567 8471212.190639675 9818149.936439816 1.0 0.636269056872498 0.7374369641211429 23.666428129474216 -10.187668849910715 7.701086940898191 1.000000173746246 0.6868530104968213 0.927402977540742 0.04130162518406593 1.2318474252810775e-07 1.3076997755087482e-08 0.03999014867519716 0.013330042209099014 6.4912920672915e-11 10.187668849910715 -0.3131471632494247 EFSIYMTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFSIYMTK 8 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 22249600.0 9373600.0 8482300.0 4393700.0 False True 12134309.981279647 8010252.548459041 3594091.6831690543 1.0 0.6601325135765408 0.29619250610161457 23.53258873603889 -7.3268611526187035 0.30680285568306 1.0740581247542837 4.8277902676530554e-17 0.9998291383984352 0.0037565108384167724 0.10774267284024988 0.02292424361896955 0.014248207313851026 0.05133110342665548 4.7112792564641195e-08 7.3268611526187035 -1.0740581247542837 down EFSK(ub)AQEESTGLLSGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFSKAQEESTGLLSGLR 17 1 Q92759;Q92759-2;A0A0G2JHJ2 Q92759 GTF2H4 General transcription factor IIH subunit 4 1 11524800.0 3694000.0 4350500.0 3480300.0 True False 4842869.772746883 3701422.358116176 3120191.9413949465 1.0 0.7643035084168128 0.6442857412672423 22.207430777975397 -13.999999999996733 0.08671064022790115 2.2252934694575295 0.32647524275892215 0.999857573644437 0.0017633622185677753 12.193810377933563 0.08473596224845609 2.7868287087048556 0.28644674874943454 1.000000000007522e-14 13.999999999996733 -1.8988182266986073 EFSK(ub)AQEESTGLLSGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFSKAQEESTGLLSGLR 17 1 Q92759;Q92759-2;A0A0G2JHJ2 Q92759 GTF2H4 General transcription factor IIH subunit 4 1 35304200.0 8212200.0 10538000.0 16554000.0 True False 12458507.792239351 8657411.566230202 13282094.644124053 1.0 0.6948995586472301 1.0661063801234472 23.57062794528163 -6.688342401749567 1.8724644154233878 0.8084205458458563 1.064791925172556 0.3625697410055896 0.1290805097274437 0.420262096269565 2.8555693969719504 0.05517667924773799 0.1439764397830718 2.0495456610886055e-07 6.688342401749567 0.2563713793266996 EFSK(ub)AQEESTGLLSGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFSKAQEESTGLLSGLR 17 1 Q92759;Q92759-2;A0A0G2JHJ2 Q92759 GTF2H4 General transcription factor IIH subunit 4 1 33618900.0 8212200.0 9487700.0 15919000.0 True False 10630854.78666306 8959701.154641422 13021905.342733521 1.0 0.84280157470327 1.2249161148424448 23.34175426737408 -6.795022028920709 1.4764409529753506 0.9127116548725853 1.2295477748362076 0.8171162330630909 0.0670605275126488 0.22794728211915916 0.9814758445919465 0.035743386407758065 0.08337997337399855 1.603164070591916e-07 6.795022028920709 0.31683611996362226 EFSLAGGIWHGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFSLAGGIWHGR 12 0 Q8WWM7;H3BRB0;A0A0C4DGL7 Q8WWM7 ATXN2L Ataxin-2-like protein 0 2566750.0 961250.0 0.0 1605500.0 False True 1316650.101804501 0.0 1226313.9663104182 1.0 0.0 0.9313894136564643 20.32844057136504 -10.033726046701588 13.039524021043405 1.0000003502766983 0.4656947068282384 0.30497074476771135 0.3802381358814451 0.0 0.0 0.3681639919654231 0.122721330655141 9.25281658280466e-11 10.033726046701588 -0.5343056434484599 EFSPK(ub)LVGLTGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFSPKLVGLTGTR 13 1 J3QL56;O75880 J3QL56 SCO1 Protein SCO1 homolog, mitochondrial 1 6635700.0 1630000.0 3129600.0 1876100.0 True False 2136945.7849424523 2662675.8790852497 1681979.1688219605 1.0 1.2460193879728938 0.7870949186795846 21.0271188761114 -6.761069146552806 1.6082554352810559 1.1427103413816337 0.7853177842155331 0.6953918702241622 0.10349345100581404 0.2811240183188277 1.4332944759383204 0.0507659201596712 0.12187933041401419 1.7335279707004476e-07 6.761069146552806 -0.35739255716610063 EFSPK(ub)LVGLTGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFSPKLVGLTGTR 13 1 J3QL56;O75880 J3QL56 SCO1 Protein SCO1 homolog, mitochondrial 1 10967000.0 3168400.0 3810000.0 3988600.0 True False 3067820.8762944764 5331352.868887526 2943866.004564869 1.0 1.7378305591710745 0.9595951404179346 21.548782818649425 -6.65828037416852 1.9796768359428771 1.4756171916509002 0.9628919986596073 0.22811000579291663 0.3142836369132696 0.48848616722072613 3.678614701087517 0.12836376223266863 0.3481878466466292 2.196441424495706e-07 6.65828037416852 -0.5127251929912929 EFSPK(ub)LVGLTGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFSPKLVGLTGTR 13 1 J3QL56;O75880 J3QL56 SCO1 Protein SCO1 homolog, mitochondrial 1 9821700.0 3168400.0 4503700.0 2149600.0 True False 2634664.9839191455 4479437.674185541 2599071.4213725706 1.0 1.7001925108224727 0.9864902889878513 21.3291880940837 -6.6505502451348955 2.006239521076015 1.4541680922066516 0.9894775870712375 0.19625963729628726 0.2988121002101172 0.5072973554495452 3.9143273835542036 0.12075595324539719 0.3310475376867684 2.235886505778722e-07 6.6505502451348955 -0.4646905051354141 EFSQSFDAAMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFSQSFDAAMK 11 0 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 8844500.0 1765500.0 3668700.0 3410300.0 False True 2314587.597126318 3121344.2604805953 3057434.869907535 1.0 1.348553091857879 1.320941524832977 21.14232373275256 -10.304794065840806 5.224455331759897 0.9999219078289707 1.3347473083453472 0.9949230976203753 0.011272375035069546 1.0256614579666209e-05 1.3648175041138914e-06 0.010916966783466464 0.003638143398567717 4.9568517954379206e-11 10.304794065840806 0.33482540051637644 EFSQSFDAAMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFSQSFDAAMK 11 0 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 6713600.0 1765500.0 1999000.0 2949100.0 False True 2418253.0608435315 1910677.5701909908 2252583.318621025 1.0 0.7901065447321345 0.9314919745559144 21.20553379427545 -10.107667606939351 4.5619001623904945 1.0000118279709629 0.8607992596399778 0.5637847665661238 0.057720360035848815 80417721.41881317 2.0284642917702884 9991.325000454717 0.01975921450978635 7.804271923382386e-11 10.107667606939351 -0.13921256833098505 EFSQSFDAAMK(ub)GLALSNSDVIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFSQSFDAAMKGLALSNSDVIR 22 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 57939500.0 6965600.0 9384900.0 41589000.0 True False 10567324.453571808 7710091.270441615 33368915.920893714 1.0 0.7296162149952314 3.1577449966168927 23.333106810451547 -6.879262208938736 1.0839537259521437 0.8340194998433205 3.327376242015608 0.9730833310883731 0.17825814356784095 0.12828339784024692 0.276278762962143 0.12676805060819266 0.305979166736117 1.320498131630686e-07 6.879262208938736 2.4933567421722875 up EFSQSFDAAMK(ub)GLALSNSDVIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFSQSFDAAMKGLALSNSDVIR 22 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 63645600.0 6965600.0 10177000.0 46503000.0 True False 9017106.51250337 9610641.003698025 38039931.16107399 1.0 1.0658231651552128 4.218640548198778 23.104233132543996 -6.91141166307818 0.8860805169789311 0.9066870680302199 4.638616516028882 0.9914431631980402 0.13894045211809616 0.10349156570002693 0.13376359575144553 0.1145524378684054 0.3193907131137468 1.2262763059343516e-07 6.91141166307818 3.7319294479986618 up EFTEAVEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFTEAVEAK 9 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2 P35232 PHB Prohibitin 0 10575340.0 3867900.0 893540.0 5813900.0 False True 3745115.631681413 1250335.1817495439 4291065.176738632 1.0 0.3338575640155045 1.1457764188744444 21.836578832381495 -6.6886371624716245 1.870954955597258 0.5818521838173931 1.1429515178148133 0.3642286864826745 0.2818075909333387 0.4195823887091152 2.846470052492818 0.1205357518264323 0.3144589010585719 2.0481550825365758e-07 6.6886371624716245 0.5610993339974202 EFTEAVEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFTEAVEAK 9 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2 P35232 PHB Prohibitin 0 13679600.0 3213500.0 5324100.0 5142000.0 False True 4401617.791572187 5088863.657555705 3927565.502814181 1.0 1.1561348346281664 0.8923004424269464 22.06960244555247 -6.746367295746177 1.6632532446448078 1.0922092902860536 0.8919173283270553 0.6331794203082604 0.06560070209777617 0.3064388349347912 1.6667364665590962 0.031172058470458383 0.07596929124918426 1.7932164089515687e-07 6.746367295746177 -0.20029196195899834 EFTEAVEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFTEAVEAK 9 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2 P35232 PHB Prohibitin 0 6281670.0 3867900.0 1588300.0 825470.0 False True 3216330.227023371 1579743.5126471352 998071.9604579536 1.0 0.4911633449122375 0.3103138950323652 21.61698410781577 -13.999999999999998 0.14409441326669972 3.4408441398370804 0.09717090599541127 0.99958712697807 0.005932886623520314 11.940403167598042 0.11921345016109015 8.177957472773528 0.19111939037663997 1.0000000000000041e-14 13.999999999999998 -3.343673233841669 EFTEAVEAK(ub)QVAQQEAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFTEAVEAKQVAQQEAER 18 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2 P35232 PHB Prohibitin 1 24060900.0 4574100.0 8026800.0 11460000.0 True False 5996689.395647414 6829232.72822134 10274229.132082323 1.0 1.138833826073802 1.7133168743973435 22.515734818271937 -6.944097131062886 0.6202843401190116 0.9937137364759 1.8888864920054 0.998652720428894 0.01133400044139431 0.085946362627449 0.04646572487861304 0.011411254978919235 0.048623796718364885 1.137372881044461e-07 6.944097131062886 0.8951727555295 EFTEAVEAK(ub)QVAQQEAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFTEAVEAKQVAQQEAER 18 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2 P35232 PHB Prohibitin 1 35594900.0 9202800.0 8516100.0 17876000.0 True False 8910662.151358033 11916623.140874827 13193739.331495147 1.0 1.3373442891736917 1.480668788400237 23.087101211731994 -12.210910304799931 0.13830032342086657 1.113840838174208e-13 1.6808571375505643 0.999652221150956 0.0037575564102582666 6.023152528047827 0.09840447948283239 1.8758757294478983 0.1580081448823844 6.153039388214327e-13 12.210910304799931 1.6808571375504529 EFTEAVEAK(ub)QVAQQEAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFTEAVEAKQVAQQEAER 18 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2 P35232 PHB Prohibitin 1 200061300.0 26359500.0 47630800.0 126071000.0 True False 39989288.637579784 39130711.59886102 101153011.59111777 1.0 0.9785298246612989 2.5295026502686926 25.253110281739573 -6.903761622370624 0.937174654766576 0.9420012829504061 2.705337750156472 0.9883467827343213 0.07838556027751058 0.10868933973657433 0.16221301261438195 0.06225829747353765 0.1652682911678569 1.24806837200043e-07 6.903761622370624 1.763336467206066 up EFTEAVEAK(ub)QVAQQEAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFTEAVEAKQVAQQEAER 18 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2 P35232 PHB Prohibitin 1 30463400.0 4574100.0 5433300.0 20456000.0 True False 6265268.380404654 5193238.840479601 15624714.104544342 1.0 0.8288932772173099 2.493861899581577 22.57894487979483 -6.881557741734451 1.0711133837461755 0.8916107667469375 2.6154202498375887 0.9749186971509649 0.11843175890830518 0.12625735728513546 0.2640454714588565 0.08505327869724381 0.20651220849992036 1.3135368417214305e-07 6.881557741734451 1.7238094830906512 up EFTEAVEAK(ub)QVAQQEAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFTEAVEAKQVAQQEAER 18 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2 P35232 PHB Prohibitin 1 39795500.0 9202800.0 11353000.0 19239700.0 True False 7652535.953165983 11291839.135605935 23262632.315678194 1.0 1.4755682566815398 3.0398592646995737 22.86750648716627 -6.949364536243315 0.5657758318794018 0.9801264725491324 3.6108061910593503 0.9991504759003629 0.025398633047035844 0.08374190124645217 0.03702599085387644 0.027039786042500735 0.13020444575378834 1.1236614039178047e-07 6.949364536243315 2.6306797185102178 up EFTEAVEAK(ub)QVAQQEAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFTEAVEAKQVAQQEAER 18 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2 P35232 PHB Prohibitin 1 175796900.0 26359500.0 30816400.0 118621000.0 True False 34122892.373425454 29101440.250207316 97033195.15424281 1.0 0.8528421310753601 2.843639222969599 25.024236603832023 -6.889102216762854 1.0276582228255418 0.8907188062989196 3.0118976793411156 0.9803181630330084 0.12707363854661374 0.1198754386219613 0.22611644607188094 0.09432505708426758 0.23441121602980533 1.2909154043982673e-07 6.889102216762854 2.121178873042196 up EFTNVYIK(ub)NFGEDMDDER ddPTM_RPMI8226_Bortezomib_2h_R1 2 EFTNVYIKNFGEDMDDER 18 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 35010700.0 13741800.0 11051100.0 10217800.0 True False 13305574.080881013 15463861.860725166 7541451.652570547 1.0 1.1622092941442814 0.5667888966479828 23.665527422281 -6.834122389966997 1.3094117142068695 1.0864572284227954 0.5493767813332187 0.9138672712801417 0.07376181291714469 0.1757778694009893 0.5879527047341163 0.04420978937624989 0.10174551889047911 1.4651348882532186e-07 6.834122389966997 -0.5370804470895767 EFTNVYIK(ub)NFGEDMDDER ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EFTNVYIKNFGEDMDDER 18 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 20049300.0 5478600.0 7148100.0 7422600.0 True False 7504186.473598062 6832273.30639431 5669534.753245544 1.0 0.9104615577494322 0.755516240593519 22.839264247549615 -6.962773546613772 0.39440255524516454 1.0090616049072938 0.6513093708861278 0.9998596363729582 0.0011965101592901995 0.07872483949673897 0.017576452676114362 0.001996431893997107 0.013010040730649644 1.0894980402414423e-07 6.962773546613772 -0.35775223402116596 EFTNVYIK(ub)NFGEDMDDER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFTNVYIKNFGEDMDDER 18 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 26462500.0 10005000.0 10631000.0 5826500.0 True False 8319600.7966516325 10573728.692911724 7044794.21130782 1.0 1.2709418337917493 0.846770702524948 22.98808287383137 -6.734143587589248 1.7079657727407187 1.1622911497347774 0.8468177179213711 0.578456693557869 0.11386509391603608 0.328513127890782 1.8792061606274741 0.052789956281384186 0.13039250249511922 1.8444055161354891e-07 6.734143587589248 -0.31547343181340637 EFTNVYIK(ub)NFGEDMDDER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFTNVYIKNFGEDMDDER 18 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 32739400.0 11205000.0 9204400.0 12330000.0 True False 14505093.383570734 8692167.048682136 10086066.516483711 1.0 0.5992492994583104 0.695346541367858 23.79005624782609 -9.81105740478983 6.169997089762946 1.0000000162792977 0.6472979204128185 0.9472604426844183 0.0392315347288292 8.7982261145403e-09 1.6971798320369902e-09 0.03798577214341392 0.01266192338743455 1.545050202211434e-10 9.81105740478983 -0.35270209586647916 EFTNVYIK(ub)NFGEEVDDESLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFTNVYIKNFGEEVDDESLK 20 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 13011700.0 3523100.0 2797500.0 6691100.0 True False 3411261.1189474375 3914556.3387697726 4938500.181302711 1.0 1.1475393416900403 1.4477051181665364 21.701873761271134 -6.959709205343019 0.4395140969642725 0.9892128135220833 1.6177252122833954 0.9997592576593497 0.002890314709331905 0.07980518009515702 0.021516486946124253 0.003955130799809365 0.02487290786594594 1.0972126212527762e-07 6.959709205343019 0.628512398761312 EFTNVYIK(ub)NFGEEVDDESLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFTNVYIKNFGEEVDDESLK 20 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 12054500.0 3523100.0 5116800.0 3414600.0 True False 2929613.7497934396 5089234.782794724 4128577.0726734204 1.0 1.73716920298915 1.409256449920921 21.48227903670541 -10.12344625223927 4.348646567187779 0.9999293168248565 1.5732128261856495 0.8029288151534355 0.1338698213889514 19831746.796709776 23083706.568863966 13436.613694718259 0.04582720199906235 7.525818630331897e-11 10.12344625223927 0.573283509360793 EFVMIVVFGLEFIIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFVMIVVFGLEFIIR 15 0 A6PVT8 A6PVT8 KCNQ5 0 11098100.0 1625400.0 1999700.0 7473000.0 False True 2130915.14039599 1701352.5547695481 6699765.646077764 1.0 0.7984140346637099 3.1440790480435274 21.023041711028768 -6.885994116178955 1.0458207980827678 0.8615966150680738 3.330655801324893 0.9782067481956812 0.1566951887452812 0.12245221398256191 0.2413323943349725 0.11472323213175704 0.2821703194964386 1.3001871928482733e-07 6.885994116178955 2.469059186256819 up EFVMIVVFGLEFIIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFVMIVVFGLEFIIR 15 0 A6PVT8 A6PVT8 KCNQ5 0 41719500.0 5777400.0 6535100.0 29407000.0 False True 5593999.599388867 9144599.510096293 21704424.508910168 1.0 1.6347157963857062 3.879947454998269 22.41544871982049 -6.947700293943403 0.5835448713481514 0.9735030174660942 4.652891364515898 0.9990082375431628 0.038908523486454495 0.08442254328295244 0.0398869382602261 0.04061130089648021 0.1877416757244077 1.1279756021405083e-07 6.947700293943403 3.6793883470498034 EFVMIVVFGLEFIIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFVMIVVFGLEFIIR 15 0 A6PVT8 A6PVT8 KCNQ5 0 72507700.0 7171700.0 11859000.0 53477000.0 False True 10879993.221500074 9742668.795210082 42907247.5101982 1.0 0.8954664398096762 3.943683294343301 23.375174321966032 -6.898956172233088 0.9678167971901189 0.8696111623040448 4.256977362752425 0.9860405862888916 0.16693987497583773 0.11217860551273406 0.18177321730985335 0.12961603316081477 0.3355165370439936 1.261954881070956e-07 6.898956172233088 3.3873662004483807 up EFVMIVVFGLEFIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFVMIVVFGLEFIIR 15 0 A6PVT8 A6PVT8 KCNQ5 0 23072200.0 1625400.0 2147800.0 19299000.0 False True 2226354.3047833927 2052903.0941751935 14740973.675381364 1.0 0.9220918205895918 6.621126585157589 21.08625177255166 -6.903800659336623 0.936914080643987 0.7871247583035783 7.267768158974954 0.9883645143286023 0.2878322653835293 0.10866193818113705 0.16205653109350862 0.22865559470799132 0.6071189910297177 1.2479561932483605e-07 6.903800659336623 6.480643400671376 up EFVMIVVFGLEFIIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFVMIVVFGLEFIIR 15 0 A6PVT8 A6PVT8 KCNQ5 0 47138800.0 5777400.0 5256400.0 36105000.0 False True 4804164.082216403 5228082.729886294 43654388.56934154 1.0 1.0882398353626415 9.086781346818938 22.195853995254765 -6.9093085992415615 0.9004052378006872 0.7468999825165636 10.105402570890998 0.9906586053732076 0.3664535999596852 0.1048777099169377 0.141250949662605 0.29899839887847796 0.8214963036091926 1.232228929747354e-07 6.9093085992415615 9.358502588374435 up EFVMIVVFGLEFIIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFVMIVVFGLEFIIR 15 0 A6PVT8 A6PVT8 KCNQ5 0 38212400.0 7171700.0 9491700.0 21549000.0 False True 9283907.025341738 8963478.551125133 17627303.11141182 1.0 0.9654856006913953 1.8986944896470421 23.14630064405848 -6.898313147214428 0.9718942639084324 0.9593842603937413 1.993354792666824 0.9857074734518241 0.05164781266807174 0.11265688973594049 0.18451604483810588 0.03998030864792059 0.10316627863899766 1.263824740416639e-07 6.898313147214428 1.0339705322730828 EFVSASFDK(ub)SIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFVSASFDKSIR 12 1 A0A087WT20;Q9NV06;A0A087X1F8 A0A087WT20 DCAF13 DDB1- and CUL4-associated factor 13 1 2046760.0 0.0 946860.0 1099900.0 True False 0.0 941759.0772430052 1329884.004636998 0.0 EFWEIVHSFTDEQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFWEIVHSFTDEQKR 15 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG63;S4R306 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 20451300.0 1841000.0 11061000.0 7549300.0 True False 2792931.5951282983 9087078.130012559 6057177.546024268 1.0 3.253598529180994 2.1687525597081514 21.41334880868579 -10.429738968898082 6.437481942822786 0.9996350364673473 2.711175544444573 0.7683766034618972 0.44288651245390026 0.002320275129827328 0.00020553963412755675 0.4289018319413838 0.1429410072494865 3.717586061041288e-11 10.429738968898082 1.7115405079772255 EFWEIVHSFTDEQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFWEIVHSFTDEQKR 15 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG63;S4R306 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 12642000.0 1841000.0 10801000.0 0.0 True False 2383210.7915353575 10199914.855157923 0.0 1.0 4.279904610782137 0.0 21.18447513077824 -6.701937814179171 1.823901962080264 3.032804648776127 0.012234961924498964 0.42680039171766826 1.384003182057478 0.39150805800876654 2.5333588131502545 0.6050524888599514 1.5523569500489822 1.9863793229637365e-07 6.701937814179171 -3.020569686851628 EFYGENIK(ub)ESPDYER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFYGENIKESPDYER 15 1 J3QRD1;A0A5F9ZI12;A0A5F9ZHI5;A0A5F9ZGX4;A0A5F9ZHN9;P51648;P51648-2;J3QS00;I3L1M4 J3QRD1 ALDH3A2 Fatty aldehyde dehydrogenase 1 8115900.0 2163500.0 3111600.0 2840800.0 True False 2094820.8767400258 4354078.106779637 2096709.2578267783 1.0 2.078496617598867 1.0009014522949051 20.998395457025882 -6.646033596083367 2.0231552738407586 1.7020477419494653 1.0054637808625801 0.1779286913733774 0.4607717571143693 0.5183357426013697 4.062156107161549 0.18501900425687257 0.5101477089519986 2.259260991908819e-07 6.646033596083367 -0.6965839610868851 EFYGENIK(ub)ESPDYER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFYGENIKESPDYER 15 1 J3QRD1;A0A5F9ZI12;A0A5F9ZHI5;A0A5F9ZGX4;A0A5F9ZHN9;P51648;P51648-2;J3QS00;I3L1M4 J3QRD1 ALDH3A2 Fatty aldehyde dehydrogenase 1 8539100.0 2163500.0 4006000.0 2369600.0 True False 1799046.109300931 3984418.882871262 2865072.404207497 1.0 2.214739723608039 1.5925508464709668 20.77880073246016 -10.163227534610423 5.687696329974613 0.999984271391413 1.9036452850395547 0.7377038902365715 0.2540075454370236 5.066187164213502e-05 7.4533549036637054e-06 0.24594601824611703 0.08198058277402469 6.867085669074434e-11 10.163227534610423 0.9036610136481417 EFYYDEK(ub)EIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EFYYDEKEIER 11 1 A0A3B3IRZ7;A0A0U1RR16;Q8NEY4-2;Q8NEY4 A0A3B3IRZ7 ATP6V1C2 V-type proton ATPase subunit C 2 1 10569900.0 4703300.0 2488300.0 3378300.0 True False 6166071.846821991 2117055.339317433 3028745.922941857 1.0 0.3433393888215183 0.49119536686924603 22.555920269091985 -10.126040093740967 7.804131425834007 1.0000000880990754 0.4172673778477736 0.9539402521215926 0.0603619502728473 9.254261599610702e-08 1.0266736017509947e-08 0.05844521574670123 0.01948173567927816 7.481004332519584e-11 10.126040093740967 -0.5827327102513018 EFYYDEK(ub)EIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EFYYDEKEIER 11 1 A0A3B3IRZ7;A0A0U1RR16;Q8NEY4-2;Q8NEY4 A0A3B3IRZ7 ATP6V1C2 V-type proton ATPase subunit C 2 1 9349200.0 3582400.0 3408200.0 2358600.0 True False 3468678.6729066214 4769112.033528209 1740811.9035166993 1.0 1.374907416699937 0.5018660036497312 21.725954769569228 -6.790014013140343 1.4963330500447125 1.209530522495123 0.4925840654463274 0.8013580940746053 0.15937929902332826 0.2353277426019873 1.0409219267839454 0.0838393821139557 0.1962817799627806 1.621757768151903e-07 6.790014013140343 -0.7169464570487956 EFYYDEK(ub)EIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EFYYDEKEIER 11 1 A0A3B3IRZ7;A0A0U1RR16;Q8NEY4-2;Q8NEY4 A0A3B3IRZ7 ATP6V1C2 V-type proton ATPase subunit C 2 1 20851600.0 7557100.0 7553500.0 5741000.0 True False 11464673.198014162 6205518.909235124 4606288.833630311 1.0 0.5412730744309401 0.40178108473499125 23.450691895508438 -13.999999999999998 0.1667716945619381 3.294477332289709 0.27440693275205036 0.9995202125421088 0.00559758708985038 12.061733021690186 0.12924979841338372 8.951163609989242 0.11715771472816211 1.0000000000000041e-14 13.999999999999998 -3.020070399537659 EFYYDEK(ub)EIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EFYYDEKEIER 11 1 A0A3B3IRZ7;A0A0U1RR16;Q8NEY4-2;Q8NEY4 A0A3B3IRZ7 ATP6V1C2 V-type proton ATPase subunit C 2 1 11698900.0 4703300.0 4704100.0 2291500.0 True False 6442237.111903368 4496257.307621528 1750294.894923902 1.0 0.6979341538537539 0.2716905423567645 22.619130330614876 -7.159035349887479 0.37462568381079514 1.0358346592973153 7.724171787253804e-16 0.9998195285442099 0.004013638141243548 0.08316383662086209 0.020410718662815058 0.007767711181536673 0.03980173974304442 6.933693661407381e-08 7.159035349887479 -1.0358346592973147 down EFYYDEK(ub)EIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EFYYDEKEIER 11 1 A0A3B3IRZ7;A0A0U1RR16;Q8NEY4-2;Q8NEY4 A0A3B3IRZ7 ATP6V1C2 V-type proton ATPase subunit C 2 1 10146700.0 3582400.0 4939800.0 1624500.0 True False 2978924.3272288707 4913188.31692647 1964175.4391606546 1.0 1.6493162555414553 0.6593572791383455 21.506360045003504 -6.729780702805996 1.7242807058826264 1.390854583993903 0.6599959000257287 0.5581577582712536 0.27296107975535755 0.3366391141798544 1.9607596871917932 0.1254620727754807 0.3113731315750455 1.8630276358329377e-07 6.729780702805996 -0.7308586839681743 EFYYDEK(ub)EIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EFYYDEKEIER 11 1 A0A3B3IRZ7;A0A0U1RR16;Q8NEY4-2;Q8NEY4 A0A3B3IRZ7 ATP6V1C2 V-type proton ATPase subunit C 2 1 16319500.0 7557100.0 4308300.0 4454100.0 True False 9782814.922711493 4068539.317699924 3643499.5029253904 1.0 0.4158863629582242 0.37243876447736424 23.221818217600887 -13.999999999999998 0.3686849175185483 9.069301949383012 0.3678412765735697 0.9997886414926368 0.004160018700733719 22.666675923608587 0.19696746542437543 144.47358209097598 0.012192776314285813 1.0000000000000041e-14 13.999999999999998 -8.701460672809443 EGAAHAFAQYNLDQFTPVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGAAHAFAQYNLDQFTPVK 19 0 P47755;F8W9N7;A0A0D9SET8;C9JUG7;P47755-2 P47755 CAPZA2 F-actin-capping protein subunit alpha-2 0 25094300.0 6419800.0 10583000.0 8091500.0 False True 8416419.96943164 9004057.652210897 7254269.199148703 1.0 1.0698203850227948 0.8619186335159298 23.00477526453181 -6.816119235713681 1.3884627137494305 1.0377867324857577 0.857742385699835 0.8752562611448731 0.030511107477598633 0.19856816684543388 0.7531939873482947 0.017272350315007044 0.03985928971384395 1.5271467219681822e-07 6.816119235713681 -0.18004434678592274 EGAAHAFAQYNLDQFTPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGAAHAFAQYNLDQFTPVK 19 0 P47755;F8W9N7;A0A0D9SET8;C9JUG7;P47755-2 P47755 CAPZA2 F-actin-capping protein subunit alpha-2 0 28119300.0 9253400.0 4188900.0 14677000.0 False True 8959655.88205507 5861549.614824922 10832653.399438035 1.0 0.6542159310565466 1.2090479301927561 23.095011892367506 -6.738154820847466 1.6933009238866783 0.793826083405542 1.2092549831998471 0.5967240785527643 0.1452911978043777 0.32115030431903835 1.8072924654382394 0.06789716960404367 0.16696193321621183 1.8274486361793078e-07 6.738154820847466 0.4154288997943052 EGAAHAFAQYNLDQFTPVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGAAHAFAQYNLDQFTPVK 19 0 P47755;F8W9N7;A0A0D9SET8;C9JUG7;P47755-2 P47755 CAPZA2 F-actin-capping protein subunit alpha-2 0 23383000.0 6419800.0 7061300.0 9901900.0 False True 8793373.548571697 6749308.417403527 7563275.156031847 1.0 0.7675448313576777 0.860110754337321 23.0679853260547 -10.258065061433589 6.120850808965193 1.0000053535467863 0.8138277928775804 0.8435897699803331 0.037789879811650114 2.7608494627089818e-06 3.3463998531014655e-07 0.03659094563131583 0.01219663126380823 5.5199473903752825e-11 10.258065061433589 -0.18617756066920588 EGAAHAFAQYNLDQFTPVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGAAHAFAQYNLDQFTPVK 19 0 P47755;F8W9N7;A0A0D9SET8;C9JUG7;P47755-2 P47755 CAPZA2 F-actin-capping protein subunit alpha-2 0 17919200.0 9253400.0 4993800.0 3672000.0 False True 7694612.095126058 4966897.4082083125 4439798.2225902835 1.0 0.6455032881195477 0.5770009154071005 22.875417167801782 -13.999999999999998 0.23112812537250613 3.249579583469868 0.5440499773792644 0.999511354507636 0.004097861755499664 13.32669008337344 0.15221466088549232 13.766673522173523 0.03531103663763366 1.0000000000000041e-14 13.999999999999998 -2.705529606090604 EGAAHAFAQYNMDQFTPVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGAAHAFAQYNMDQFTPVK 19 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 34564000.0 8745000.0 12903000.0 12916000.0 False True 11464779.686700463 10977922.695500081 11579576.219020525 1.0 0.9575345532574732 1.0100129732499987 23.450705295801974 -9.92660819374157 4.2618000095008695 1.000000337310382 0.9837737632905669 0.11305955329565742 0.021424225289032362 22159905.518570945 115.60851917043367 93.95928846043539 0.007840463626486851 1.1841093386591052e-10 9.92660819374157 -0.0162265740198152 EGAAHAFAQYNMDQFTPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGAAHAFAQYNMDQFTPVK 19 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 34207500.0 8184000.0 4934500.0 21089000.0 False True 7924203.399695114 6904871.583077549 15565158.243561288 1.0 0.8713647586763378 1.9642552643411655 22.91783448134932 -6.877545229993142 1.0933509359977804 0.9225824168257241 2.0381663713902403 0.9716529626352712 0.08211359023130547 0.1298290098500345 0.285588371703435 0.057973438337927154 0.1393662995906874 1.3257290413159112e-07 6.877545229993142 1.1155839545645163 EGAAHAFAQYNMDQFTPVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGAAHAFAQYNMDQFTPVK 19 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 36858000.0 8745000.0 10197000.0 17916000.0 False True 11978262.824738998 9746462.823030276 13684609.791602286 1.0 0.8136791591265362 1.142453625523989 23.513915357324866 -6.752962959084144 1.6387528687124029 0.8908307998215073 1.1432617732189685 0.6616251367886292 0.07830802857318736 0.29492919629595377 1.559171429777731 0.03773306044836493 0.09132706919780235 1.766188452229429e-07 6.752962959084144 0.25243097339746123 EGAAHAFAQYNMDQFTPVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGAAHAFAQYNMDQFTPVK 19 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 19723500.0 8184000.0 6566800.0 4972700.0 False True 6805358.6126733655 6531423.344992251 6012468.578832981 1.0 0.9597471223381271 0.8834903376930329 22.698239756783597 -6.961091496534379 0.41977055068027697 1.0033790242155163 0.8369829339081721 0.9998085422765517 0.000668514630281089 0.079313533234225 0.019707763051235616 0.0009863031283283146 0.00634819559946818 1.0937259174005586e-07 6.961091496534379 -0.16639609030734415 EGAAHAFAQYNMDQFTPVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGAAHAFAQYNMDQFTPVK 19 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 21504100.0 4209700.0 8646400.0 8648000.0 False True 5449539.635592825 8165220.239203547 7074152.7359733265 1.0 1.4983321133905834 1.2981193291575663 22.377702928846762 -10.038292993769902 4.328191921525882 0.9999735405248718 1.398225721334814 0.8406347579202041 0.08173652713880852 25132478.313479148 32765962.032287803 8578.34761153259 0.029912505228758057 9.156025767611726e-11 10.038292993769902 0.3982521808099422 EGAGEQK(ub)TEHMTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGAGEQKTEHMTR 13 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7ER69;K7EJ09;K7EKY0;K7EM82 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 15303800.0 5485200.0 5924300.0 3894300.0 True False 7191150.318752365 5040417.532740533 3491355.1927633677 1.0 0.700919506521319 0.4855071912012407 22.77779113643079 -7.69999851906883 0.14269895934698779 1.3379749775414285 9.246215682665477e-14 0.9999785449193189 0.0009771630256785438 0.13487414548631424 0.01711499331525434 0.0599676383797454 0.08777274835790892 1.9952691187651895e-08 7.69999851906883 -1.337974977541336 down EGAGEQK(ub)TEHMTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGAGEQKTEHMTR 13 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7ER69;K7EJ09;K7EKY0;K7EM82 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 13918300.0 5378400.0 4900600.0 3639300.0 True False 5207665.635987318 6857435.13629139 2686058.153340249 1.0 1.316796356683006 0.5157892885400276 22.31220539094818 -6.7994174335239235 1.4584669338853855 1.1749174324358422 0.5049101802336053 0.8304171585699726 0.1356409304859717 0.22158307493028953 0.9306191357638276 0.0731698580833794 0.17021344600795305 1.5870206088174642e-07 6.7994174335239235 -0.6700072522022369 EGAGEQK(ub)TEHMTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGAGEQKTEHMTR 13 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7ER69;K7EJ09;K7EKY0;K7EM82 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 13428600.0 5485200.0 4245700.0 3697700.0 True False 7513226.671956364 4058110.935347621 2824379.41652198 1.0 0.5401289103248808 0.3759209644325215 22.84100119795368 -13.999999999999998 0.1434079675730409 3.204234760638818 0.18081309630773357 0.9995897034309746 0.005350319299396933 11.93904325921326 0.1188852090864642 7.351477544202491 0.17485422264864622 1.0000000000000041e-14 13.999999999999998 -3.0234216643310847 EGAGEQK(ub)TEHMTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGAGEQKTEHMTR 13 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7ER69;K7EJ09;K7EKY0;K7EM82 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 11820100.0 5378400.0 4326900.0 2114800.0 True False 4472377.903519359 4303590.13087759 2556994.902269592 1.0 0.9622599484473464 0.5717305105763685 22.092610666382456 -6.925644473735443 0.7817212694339853 1.0069944042875087 0.49978080770679917 0.9956106405896649 0.012826882504301978 0.09496349874503929 0.08922937968084428 0.011396111609644847 0.03621927780714844 1.1867398508496482e-07 6.925644473735443 -0.5072135965807096 EGAGEQK(ub)TEHMTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGAGEQKTEHMTR 13 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7ER69;K7EJ09;K7EKY0;K7EM82 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 7371700.0 2223600.0 2517000.0 2631100.0 True False 2878494.033708865 2376926.73737918 2152266.797365801 1.0 0.8257535744538512 0.7477058392900892 21.45688279128939 -13.99999999997626 0.10858606434040463 1.8429288615928894 0.6015711525974384 0.9997502459153907 0.00166671616232934 12.021123880087682 0.09975982075077892 2.227505743610075 0.1298476968355214 1.0000000000546616e-14 13.99999999997626 -1.241357708995451 EGAK(ub)DIDISSPEFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGAKDIDISSPEFK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 210582000.0 18439000.0 101480000.0 90663000.0 True False 27973311.071466964 83370101.1331411 72743418.31099546 1.0 2.98034440471294 2.6004579195200965 24.737547693272923 -10.065769366160252 5.5002566523426895 0.9999869851499666 2.79040116211742 0.9673377291680596 0.15508800815347804 2.4751989907036957e-05 4.2041264980347685e-06 0.15016440595569955 0.05005443939744805 8.594698252578124e-11 10.065769366160252 1.7904141769674533 EGAK(ub)DIDISSPEFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGAKDIDISSPEFK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 138763000.0 18439000.0 29648000.0 90676000.0 True False 23869648.98702903 27998062.737313434 74173898.41432913 1.0 1.1729566175241126 3.10745660544216 24.508674015365372 -6.92443405553426 0.7911454339858675 0.9637439481785393 3.4536136816172363 0.9953266496670308 0.06530690369018391 0.0956323958599508 0.09260565560950973 0.057633218733034904 0.18069035326287908 1.1900520162050657e-07 6.92443405553426 2.489869733438697 up EGALCEENMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGALCEENMR 10 0 P13639 P13639 EEF2 Elongation factor 2 0 34051240.0 477240.0 18793000.0 14781000.0 False True 625666.2615987336 15989157.654540258 13251603.909363763 1.0 25.555409706260914 21.179987994721987 19.2550337847446 -9.162542286149694 11.99496679670016 0.9999986614060569 23.36769885049148 0.9721021716466971 1.786258433794508 0.0 0.0 1.7295372915270457 0.5765124305090151 6.87792940398232e-10 9.162542286149694 22.367700189085422 EGALCEENMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGALCEENMR 10 0 P13639 P13639 EEF2 Elongation factor 2 0 12701100.0 5742300.0 1247200.0 5711600.0 False True 5560013.829676098 1745213.46406208 4215560.615672846 1.0 0.31388653293399243 0.758192469445427 22.406657040758624 -9.904156292364712 6.539240645807982 1.0000000316588606 0.5360395011903094 0.5924865326504469 0.18138713902380574 8.376335724537785e-08 1.3807151009183373e-08 0.17562735394051313 0.05854244738794089 1.2469346910334794e-10 9.904156292364712 -0.46396053046855124 EGALCEENMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGALCEENMR 10 0 P13639 P13639 EEF2 Elongation factor 2 0 17440240.0 477240.0 16963000.0 0.0 False True 653688.5249260647 16213518.57086032 0.0 1.0 24.80312557527937 0.0 19.318243846267492 -6.399170578279934 3.306725486733666 9.999999999999998 1.744805311506937e-08 0.23821400456739394 10.00571033547125 0.72962800200731 14.063571084304792 3.9541440780664945 15.22293539613865 3.9886820772496447e-07 6.399170578279934 -9.999999982551945 EGAPIEPDPPVSHWK(ub)PEAVQYYEDGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGAPIEPDPPVSHWKPEAVQYYEDGAR 27 1 Q96HS1;Q96HS1-2;F5GXG4 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 42798800.0 4335800.0 14015000.0 24448000.0 True False 5612778.5713954475 13235052.92982487 19998714.857663717 1.0 2.35802156836812 3.5630685592308415 22.42028371427324 -6.972535790307519 0.18799951305629814 0.16162599060589145 5.792315921008322 0.9999959989762726 0.002094238786347715 0.07548816298568785 0.00598349837111819 0.0432782964241056 0.13210025682125795 1.0652810699935992e-07 6.972535790307519 5.630689930402431 EGATVYATGTHAQVEDGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGATVYATGTHAQVEDGR 18 0 P32322-2;P32322;P32322-3;E2QRB3;J3QKT4;J3KQ22;J3QL24;J3QR88;J3QLK9;J3QL23;J3QL32 P32322-2 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial;Pyrroline-5-carboxylate reductase 0 9977400.0 2253200.0 3914100.0 3810100.0 False True 2953967.0200198395 3330131.5370423007 3415867.4010599316 1.0 1.1273421519174356 1.1563661266052285 21.494222288345146 -13.999999999999998 0.2077714827822813 0.270196831323977 1.1738351578677766 0.9994888749331429 0.0015353565733166783 12.695293068815998 0.14448920001571286 3.778222732527791 0.017464593716200183 1.0000000000000041e-14 13.999999999999998 0.9036383265437996 EGATVYATGTHAQVEDGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGATVYATGTHAQVEDGR 18 0 P32322-2;P32322;P32322-3;E2QRB3;J3QKT4;J3KQ22;J3QL24;J3QR88;J3QLK9;J3QL23;J3QL32 P32322-2 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial;Pyrroline-5-carboxylate reductase 0 10511300.0 2918600.0 1109600.0 6483100.0 False True 2825950.640560872 1552669.066487559 4784981.6211689515 1.0 0.5494324791813765 1.6932290155709397 21.43030483639732 -6.799844330280379 1.4565808767655142 0.7513537904423268 1.7089523958331279 0.8317020414063993 0.19299509627800637 0.22097790400052142 0.9256134222878484 0.10423788859519449 0.2424383851615896 1.5854613878030863e-07 6.799844330280379 0.9575986053908011 EGATVYATGTHAQVEDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGATVYATGTHAQVEDGR 18 0 P32322-2;P32322;P32322-3;E2QRB3;J3QKT4;J3KQ22;J3QL24;J3QR88;J3QLK9;J3QL23;J3QL32 P32322-2 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial;Pyrroline-5-carboxylate reductase 0 10966100.0 2253200.0 4505900.0 4207000.0 False True 3086268.9304404715 4306814.438981282 3213393.2458847263 1.0 1.3954760703133586 1.041190291030831 21.557432349868037 -10.542391689383253 6.839447725193422 0.9998380684600863 1.2183331806720925 0.3361539164991745 0.14463656372774938 0.0003573978578667094 2.3912313927666788e-05 0.14014670619827935 0.04668125021418678 2.8681925975964676e-11 10.542391689383253 0.21849511221200624 EGATVYATGTHAQVEDGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGATVYATGTHAQVEDGR 18 0 P32322-2;P32322;P32322-3;E2QRB3;J3QKT4;J3KQ22;J3QL24;J3QR88;J3QLK9;J3QL23;J3QL32 P32322-2 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial;Pyrroline-5-carboxylate reductase 0 4894840.0 2918600.0 1091600.0 884640.0 False True 2426945.215902798 1085719.3341343657 1069614.1338867838 1.0 0.44736046245299754 0.4407244658338523 21.210710111831595 EGDLIAAQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGDLIAAQAR 10 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 9013970.0 588870.0 4115900.0 4309200.0 False True 772014.2726251923 3501823.7636525393 3863325.3207651945 1.0 4.535957284500427 5.004214893110937 19.558267994022454 -9.830824427950688 0.5110920553276489 2.647485207513621e-20 4.988783482944914 0.9990399091650877 0.05538588661389811 1.1143229226571476 0.23057273957618526 1.9639257922574593 0.0927675506028327 1.4763032371479448e-10 9.830824427950688 4.988783482944914 EGDLIAAQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGDLIAAQAR 10 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 8151850.0 2246400.0 875050.0 5030400.0 False True 2175089.26161719 1224462.028325466 3712787.3312347988 1.0 0.5629479442214119 1.706958604758281 21.05264317702119 -6.803166670428516 1.44297836819531 0.7598159455988078 1.7240066459403223 0.841242078785255 0.18780806975634412 0.2162754259167366 0.8886986159894121 0.10237582759273826 0.23764103851906948 1.5733789284802163e-07 6.803166670428516 0.9641907003415144 EGDLIAAQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGDLIAAQAR 10 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 8186270.0 588870.0 3470700.0 4126700.0 False True 806591.1526133857 3317352.997929899 3152058.4520543204 1.0 4.112806081720027 3.90787630367818 19.621478055545346 -10.276433944159436 4.3921508834195 0.9980019625996817 4.010341192735602 0.9965363570914711 0.0836622316741436 14813363.337751964 996.4271366377188 299327.42671097774 0.028639807168626404 5.291344720159493e-11 10.276433944159436 3.0123392301359204 EGDLLFTVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGDLLFTVAK 10 0 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 17367000.0 5736600.0 2410100.0 9220300.0 False True 5554494.773056082 3372465.498505463 6805226.826929113 1.0 0.6071597213242012 1.2251747647581055 22.405224261936795 -6.735010805887101 1.705455428281825 0.7649132243782512 1.2251222410430957 0.5821280054019506 0.1650852376940816 0.3269187621145068 1.8650809196236156 0.07664830411276 0.18909219855558806 1.8407262009170342e-07 6.735010805887101 0.4602090166648446 EGDLLFTVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGDLLFTVAK 10 0 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 9548300.0 5736600.0 1983500.0 1828200.0 False True 4770237.0744699435 1972814.4918060764 2210468.1673582685 1.0 0.4135673890013717 0.4633874863764271 22.18562953737107 -10.236724656526205 8.490407616449962 1.0000001857155385 0.43847743924839366 0.9941307913943841 0.020338969584109613 7.14941353124446e-08 6.428644256529466e-09 0.01969312922194235 0.006564374206522993 5.7979617172845226e-11 10.236724656526205 -0.5615227464671448 EGDLLTK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGDLLTKER 9 1 E7EW33;H7C229;E7EVJ5;Q96F07-2;Q96F07;Q7L576-2;Q7L576-3;H0YL50;Q7L576 E7EW33;Q7L576 CYFIP2;CYFIP1 Cytoplasmic FMR1-interacting protein 2;Cytoplasmic FMR1-interacting protein 1 1 3520270.0 976900.0 772670.0 1770700.0 True False 1280725.3603130565 657390.6478440702 1587484.949753767 1.0 0.513295565321967 1.2395201960908522 20.288529705585823 -6.7260980977998175 1.737147923690858 0.7058363587726247 1.2388113998626926 0.541156739391666 0.20467049397439854 0.3436358052894958 2.029617138276443 0.09343162736434694 0.2329028292497416 1.8788923674192434e-07 6.7260980977998175 0.5329750410900679 EGDLLTK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGDLLTKER 9 1 E7EW33;H7C229;E7EVJ5;Q96F07-2;Q96F07;Q7L576-2;Q7L576-3;H0YL50;Q7L576 E7EW33;Q7L576 CYFIP2;CYFIP1 Cytoplasmic FMR1-interacting protein 2;Cytoplasmic FMR1-interacting protein 1 1 3186020.0 871000.0 658520.0 1656500.0 True False 843350.5817612944 921470.4701364347 1222612.9560652135 1.0 1.0926303841659668 1.4497090326443471 19.685772960202854 -6.9457249968266765 0.6039653687303601 0.9960105172889067 1.564732524240825 0.998821582089132 0.006655711688404164 0.08524931071855169 0.043427845915955464 0.00680460693467658 0.03004731614289266 1.133117646838199e-07 6.9457249968266765 0.5687220069519183 EGDLLTK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGDLLTKER 9 1 E7EW33;H7C229;E7EVJ5;Q96F07-2;Q96F07;Q7L576-2;Q7L576-3;H0YL50;Q7L576 E7EW33;Q7L576 CYFIP2;CYFIP1 Cytoplasmic FMR1-interacting protein 2;Cytoplasmic FMR1-interacting protein 1 1 3006190.0 976900.0 794390.0 1234900.0 True False 1338086.3297298483 759291.2231035618 943242.0535638345 1.0 0.5674456170977086 0.7049186832020543 20.351739767108715 -10.875236193175446 10.937821787629826 1.015712298393945 0.6361821501498824 0.9032730380768383 0.05612314422192478 0.0193967904014999 0.00022125183711371624 0.04901655760623061 0.01811366690902598 1.3327963871958847e-11 10.875236193175446 -0.3795301482440626 EGDLLTK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGDLLTKER 9 1 E7EW33;H7C229;E7EVJ5;Q96F07-2;Q96F07;Q7L576-2;Q7L576-3;H0YL50;Q7L576 E7EW33;Q7L576 CYFIP2;CYFIP1 Cytoplasmic FMR1-interacting protein 2;Cytoplasmic FMR1-interacting protein 1 1 4579600.0 871000.0 1760100.0 1948500.0 True False 724275.0918424355 1750617.9919475042 2355922.3411539127 1.0 2.4170622622051283 3.252800445146937 19.46617823563713 -8.681809130513455 0.21109310988290145 3.7400842149614435e-25 4.109456133988283 0.9995767752690049 0.01912932446929635 0.2557288491575376 0.06088952068820644 0.5720377236976666 0.4014946264106597 2.0806109006079432e-09 8.681809130513455 4.109456133988283 EGDLLTK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGDLLTKER 9 1 E7EW33;H7C229;E7EVJ5;Q96F07-2;Q96F07;Q7L576-2;Q7L576-3;H0YL50;Q7L576 E7EW33;Q7L576 CYFIP2;CYFIP1 Cytoplasmic FMR1-interacting protein 2;Cytoplasmic FMR1-interacting protein 1 1 7214200.0 1654500.0 2667500.0 2892200.0 True False 2141782.8650707495 2519051.280079046 2365849.276478037 1.0 1.1761469013320516 1.1046167728117882 21.03038079574087 -10.047232886953564 4.086221120267573 0.9999823905877935 1.140381837093242 0.8370140383972546 0.029202052932807896 6740317.925464445 0.1399521037095621 1138.4428814649207 0.009996639411828922 8.969476844715699e-11 10.047232886953564 0.14039944650544844 EGDQIVGATIYFDNLQSGEVTQLLNTMGHHTVGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGDQIVGATIYFDNLQSGEVTQLLNTMGHHTVGLK 35 0 Q09666;E9PLK4;E9PQE3;E9PJZ0;E9PKR9;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 965410000.0 316820000.0 341770000.0 306820000.0 False True 480639102.6445124 280778473.2388023 246176892.51601678 1.0 0.5841773415727894 0.5121865681787708 28.84037878354774 -13.999999999999998 0.24671086639678202 3.8445986946426745 0.4823208678614572 0.999536616085043 0.004628318796935824 13.869954637521738 0.1571796417837641 19.514640673802283 0.03384192435544648 1.0000000000000041e-14 13.999999999999998 -3.3622778267812174 EGDQTSNNIPADIVFVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGDQTSNNIPADIVFVLK 18 0 P25685;M0R080;P25685-2 P25685 DNAJB1 DnaJ homolog subfamily B member 1 0 9586500.0 2659000.0 3461400.0 3466100.0 False True 3485974.749792625 2944972.612431525 3107461.221178929 1.0 0.8448060653929625 0.8914181668595811 21.733130688850625 -9.926241574473282 5.357386825917459 1.0000002331662332 0.8681121161255362 0.9143438738882363 0.019029310741254475 5.2995745953899694e-08 1.063397018347348e-08 0.018425083431173543 0.006141683632184266 1.185109352713689e-10 9.926241574473282 -0.13188811704069703 EGDQTSNNIPADIVFVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGDQTSNNIPADIVFVLK 18 0 P25685;M0R080;P25685-2 P25685 DNAJB1 DnaJ homolog subfamily B member 1 0 11537000.0 2659000.0 3278300.0 5599700.0 False True 3642104.156773124 3133453.866111621 4277166.189441579 1.0 0.8603416407749955 1.1743667960421855 21.796340750373517 -6.785852798873394 1.513324202816808 0.9215209321969574 1.1773143088746898 0.7874542381844848 0.059223966384264304 0.24159558168569198 1.0931417429460035 0.030814614082393915 0.07235428690529916 1.637371403157472e-07 6.785852798873394 0.2557933766777324 EGDQTSNNIPADIVFVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGDQTSNNIPADIVFVLK 18 0 P25685;M0R080;P25685-2 P25685 DNAJB1 DnaJ homolog subfamily B member 1 0 12695700.0 6551500.0 3173000.0 2971200.0 False True 5447862.530660994 3155906.4192088107 3592464.1827233806 1.0 0.579292594379378 0.6594263644694984 22.377258868702814 -10.838378768439412 7.364127665628556 1.024564935940714 0.6193594794244387 0.9678292536897919 0.032714474647715916 0.011970509357341645 0.0002627176286789569 0.028738194351496434 0.010558551290877372 1.4508457155387073e-11 10.838378768439412 -0.4052054565162754 EGDQTSNNIPADIVFVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGDQTSNNIPADIVFVLK 18 0 P25685;M0R080;P25685-2 P25685 DNAJB1 DnaJ homolog subfamily B member 1 0 26684400.0 6020300.0 10888000.0 9776100.0 False True 7793397.027854607 10282073.228678793 7996950.111256799 1.0 1.3193313765395673 1.0261186595106944 22.893820884385757 -10.342398200611225 3.24990999592079 0.9987454498800673 1.1727250181286892 0.3163248836697722 0.11970359223649707 74575839.81695801 101207952.01577592 895680.9187168061 0.042949540817612 4.545710769807145e-11 10.342398200611225 0.17397956824862193 EGDTK(ub)DKKDEEEDMSLD ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGDTKDKKDEEEDMSLD 17 3 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 12875700.0 4583500.0 5183000.0 3109200.0 True False 6009012.886677136 4409716.603175761 2787489.80955239 1.0 0.7338504154239294 0.46388481138602056 22.518696585142575 -6.970947988819724 0.23444133116426996 1.1038717602301342 0.08610820816924303 0.9999888610722385 0.00073045637193532 0.07599626896541224 0.00792102589235267 0.006715205589900821 0.026587087324360582 1.0691829170817587e-07 6.970947988819724 -1.0177635520608912 down EGDTK(ub)DKKDEEEDMSLD ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGDTKDKKDEEEDMSLD 17 3 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 19380100.0 6351200.0 5769600.0 7259300.0 True False 6149584.632471119 8073431.368066521 5357871.555668094 1.0 1.3128417365682035 0.8712574711757586 22.55205753767663 -6.716412153994867 1.7721764479766529 1.1910596181558097 0.8720807944253901 0.4954754872821241 0.13170703933627448 0.36237767113098346 2.222174253393906 0.05905527611834875 0.14888284104073868 1.9212675428121909e-07 6.716412153994867 -0.31897882373041964 EGDTK(ub)DKKDEEEDMSLD ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGDTKDKKDEEEDMSLD 17 3 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 15803900.0 4583500.0 4477600.0 6742800.0 True False 6278143.814430094 4279764.826556865 5150289.512325071 1.0 0.6816927029801348 0.8203522672556991 22.581906646665466 -10.132285471614512 4.805718943588557 1.0000168332462895 0.751022485116246 0.8112822856570987 0.056607530077716975 79059380.29200964 0.3554253355602187 14726.363383894406 0.019378263216768513 7.374193483193464e-11 10.132285471614512 -0.2489943481300435 EGDTK(ub)DKKDEEEDMSLD ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGDTKDKKDEEEDMSLD 17 3 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 16012600.0 6351200.0 6745800.0 2915600.0 True False 5281304.20586646 6709459.036463535 3525238.4797887336 1.0 1.2704170740649032 0.6674939261921151 22.332462813110908 -6.784774000181781 1.5171684811453165 1.1521682904771011 0.6619743995783076 0.7839479234140946 0.11461245294135225 0.2432282926514817 1.1060411573135673 0.05948146614046734 0.1398079116247187 1.6414437317342107e-07 6.784774000181781 -0.4901938908987935 EGDTKDK(ub)KDEEEDMSLD ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGDTKDKKDEEEDMSLD 17 3 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 92353000.0 34317000.0 25749000.0 32287000.0 True False 33227625.61917608 36030709.97926114 23830066.110762175 1.0 1.0843600560633306 0.7171763153912973 24.985879868772418 -6.846268150043969 1.2530229946672349 1.044911349625799 0.7035257440356604 0.9346885314042571 0.04013111559059084 0.16161043515572726 0.49017185932306967 0.025084222930031364 0.05792269759841918 1.4247276405680894e-07 6.846268150043969 -0.34138560559013853 EGDTKDK(ub)KDEEEDMSLD ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGDTKDKKDEEEDMSLD 17 3 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 67127000.0 21298000.0 26713000.0 19116000.0 True False 29172446.15680861 25532731.33192193 14601194.506378047 1.0 0.87523450020878 0.5005132044084774 24.7981030278331 -6.951425336765004 0.5429725538654715 1.005411554405428 0.3529432009454677 0.9993084291168142 0.005581821954719628 0.08291844708521125 0.033632688196959824 0.006114611505115761 0.031047328371405433 1.1183420716959899e-07 6.951425336765004 -0.6524683534599603 EGDVLTLLESER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGDVLTLLESER 12 0 P62857 P62857 RPS28 40S ribosomal protein S28 0 28504900.0 4988900.0 0.0 23516000.0 False True 6540496.212576325 0.0 21082789.901400335 1.0 0.0 3.2234236082671393 22.640968663192208 -6.823375736856983 1.3572182884644148 0.4627624127407244 3.299021459390136 0.891973810068726 0.44278256469460686 0.18912637636011553 0.6836058218178618 0.2563090321914986 0.5902831086929861 1.5018420610368188e-07 6.823375736856983 2.8362590466494115 EGDVLTLLESER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGDVLTLLESER 12 0 P62857 P62857 RPS28 40S ribosomal protein S28 0 64119900.0 4988900.0 29221000.0 29910000.0 False True 6833431.149953163 27929919.59907504 22845874.01578615 1.0 4.087246799767124 3.343250779067663 22.7041787247151 -9.79667409393515 7.122331241621308 0.999999992699982 3.7152487894174424 0.9466920523410428 0.3037351035626489 3.4891262590277047e-08 4.922305465647696e-09 0.29409025163024116 0.09803008314636734 1.597077186618454e-10 9.79667409393515 2.7152487967174603 EGDYVLFHHEGGVDVGDVDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGDYVLFHHEGGVDVGDVDAK 21 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 11920800.0 5155500.0 3296900.0 3468400.0 False True 6758910.425933014 2805015.3712155437 3109523.23924209 1.0 0.4150099933937701 0.46006279759401386 22.68835926408641 -9.874160798941796 6.90769015493783 1.0000000094003392 0.4375363975738194 0.9952111487992013 0.018392730295378735 2.6606452143364525e-09 4.2258278351050854e-10 0.017808684796679845 0.00593622817710339 1.336100729321326e-10 9.874160798941796 -0.5624636118265198 EGDYVLFHHEGGVDVGDVDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGDYVLFHHEGGVDVGDVDAK 21 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 24518200.0 6749800.0 2079100.0 15689300.0 False True 6535531.2936537275 2909295.4723632657 11579801.661088988 1.0 0.4451505687362116 1.7718225406300872 22.639873091276524 -6.793095394364374 1.483837845052667 0.6911324313250172 1.787181855578737 0.8112208907033589 0.2363700084016397 0.2307710745008858 1.0036636453349999 0.12536041775701087 0.29286502282351873 1.610291889851704e-07 6.793095394364374 1.09604942425372 EGDYVLFHHEGGVDVGDVDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGDYVLFHHEGGVDVGDVDAK 21 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 14638400.0 5155500.0 4399900.0 5083000.0 False True 7061627.67214887 4205497.869476407 3882500.087671042 1.0 0.59554228355354 0.5498024347819499 22.751569325609303 -13.999999999999998 0.30767070724813955 4.856814768109916 0.5394180767927909 0.9996668640935318 0.00369251974623227 17.10556982706493 0.1764044983201046 42.180637038195904 0.01600336017225932 1.0000000000000041e-14 13.999999999999998 -4.317396691317125 EGDYVLFHHEGGVDVGDVDAK(ub)AQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGDYVLFHHEGGVDVGDVDAKAQK 24 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 1 53503000.0 13652000.0 13716000.0 26135000.0 True False 13218624.732726993 19192870.3279951 19289459.466806088 1.0 1.451956668417776 1.4592637174311163 23.656068750702858 -11.520652756834815 0.6510905143063201 1.4592301318398413e-06 1.4581556860878955 0.9999737475076287 0.0011005463949122737 4.9943306851182525 0.3283715982802007 7.0970564136022976 0.0011966686188760068 3.0154160574013547e-12 11.520652756834815 1.4581542268577636 EGDYVLFHHEGGVDVGDVDAK(ub)AQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGDYVLFHHEGGVDVGDVDAKAQK 24 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 1 105204000.0 22087000.0 31565000.0 51552000.0 True False 33507593.775990628 25931979.131529316 41362724.603955716 1.0 0.7739134986801258 1.2344283770562352 24.997984752661196 -6.773198942875682 1.5620651018043838 0.8708531837778526 1.2373463288186584 0.7426861754844385 0.09537254006203591 0.26129329018223474 1.2586563333864778 0.04811140462369308 0.11419910549054513 1.6857806212141093e-07 6.773198942875682 0.36649314504080577 EGDYVLFHHEGGVDVGDVDAK(ub)AQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGDYVLFHHEGGVDVGDVDAKAQK 24 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 1 41129800.0 7220500.0 7683300.0 26226000.0 True False 9890113.976675589 7343826.400724581 20031958.94142453 1.0 0.7425421403680422 2.025452789388173 23.23755571645994 -6.854503926819928 1.2131362712894902 0.8618845358671143 2.0813799247799976 0.9466113323211237 0.1280408520368504 0.1525693486115834 0.42982269241184606 0.08248300956839887 0.19150659015023605 1.3979642751004875e-07 6.854503926819928 1.2194953889128832 up EGDYVLFHHEGGVDVGDVDAK(ub)AQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGDYVLFHHEGGVDVGDVDAKAQK 24 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 1 43941000.0 13652000.0 15767000.0 14522000.0 True False 11352242.886145748 15682060.041495532 17558483.057858404 1.0 1.3814063175686526 1.5466972680162383 23.436474026137134 -11.786669368755769 0.1421415012524327 1.1931447542908821e-18 1.7740439114235722 0.9996495167267188 0.00428579136463533 4.935715126990567 0.09500052901169376 1.666821757446964 0.17297244567639086 1.6342956744468792e-12 11.786669368755769 1.7740439114235722 EGDYVLFHHEGGVDVGDVDAK(ub)AQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGDYVLFHHEGGVDVGDVDAKAQK 24 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 1 131524000.0 22087000.0 33317000.0 76120000.0 True False 28592056.899859566 31462879.662003193 62266941.05715659 1.0 1.100406304177358 2.1777706051453203 24.769111074753646 -6.925070071369094 0.7861899094941525 0.9802853738180769 2.373534431425261 0.9954778713065363 0.035850505066952504 0.09527889227769704 0.09081627326627555 0.03175010030255494 0.1002540734091358 1.1883104836694542e-07 6.925070071369094 1.3932490576071843 up EGEEQLQTQHQK(ub)TFIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGEEQLQTQHQKTFIGK 17 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 25345100.0 7566100.0 9152700.0 8626300.0 True False 9919230.37021663 7787152.836945173 7733733.2253125375 1.0 0.7850561531796652 0.7796706938608622 23.241796756050622 EGEEQLQTQHQK(ub)TFIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGEEQLQTQHQKTFIGK 17 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 45042000.0 4824300.0 12442700.0 27775000.0 True False 4671155.2371883085 17411134.99782332 20499894.267860714 1.0 3.7273723765822737 4.388613357281644 22.155347960555247 -9.642395517112321 0.39462967868897303 1.0625917242160303e-21 4.478591742598438 0.9984921359771507 0.05695025674386331 0.9718961385453262 0.16700130612171177 1.4662648943063794 0.16966794205519117 2.278266282918062e-10 9.642395517112321 4.478591742598438 EGEEQLQTQHQK(ub)TFIGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGEEQLQTQHQKTFIGK 17 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 153448100.0 20712100.0 30882000.0 101854000.0 True False 31421769.957336694 25370865.817832682 81722512.25580595 1.0 0.8074295576691032 2.6008245992114936 24.905261112722467 -6.8803274918198785 1.0780076865044268 0.8801349821927664 2.728703677068044 0.9739470611704277 0.12975343865077 0.1273386990952403 0.2705564939328641 0.09269412319870919 0.22433885362194633 1.3172630451463405e-07 6.8803274918198785 1.8485686948752778 up EGEEQLQTQHQK(ub)TFIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGEEQLQTQHQKTFIGK 17 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 23380000.0 7566100.0 6713100.0 9100800.0 True False 10363491.636164414 6416493.044746938 6951378.476859458 1.0 0.6191439400940857 0.6707564130801192 23.305006817573513 -10.116560133350417 5.139123024072096 1.0000102372460549 0.6449501765868025 0.98439861955978 0.021070703865083456 2.4715269788003646e-06 4.2485035914580775e-07 0.02040220940058566 0.006800540429918418 7.646098115858243e-11 10.116560133350417 -0.35506006065925233 EGEEQLQTQHQK(ub)TFIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGEEQLQTQHQKTFIGK 17 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 26913400.0 4824300.0 15966300.0 6122800.0 True False 4011619.202727285 15880286.372837584 7403049.171371406 1.0 3.958572728448759 1.845401768527399 21.935753235989523 -9.224053841910163 11.139808632077658 0.9999999920226149 2.9019872484883042 0.5192657830072285 0.8626984318457936 0.0 0.0 0.8353041710579961 0.2784347216114983 5.969612733760801e-10 9.224053841910163 1.9019872564656892 EGEEQLQTQHQK(ub)TFIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGEEQLQTQHQKTFIGK 17 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 108562100.0 20712100.0 28569000.0 59281000.0 True False 26812221.746528793 26979110.035830628 48492466.27442586 1.0 1.0062243364566923 1.808595599904132 24.676387434814917 -6.908600399851797 0.9052142721808158 0.9740436985964963 1.9092428104853156 0.9903824951610187 0.03723842301973656 0.10535100301710727 0.1438421531221625 0.03027811831112422 0.08279247802808673 1.234239951579708e-07 6.908600399851797 0.9351991118888193 EGEFVAQFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGEFVAQFK 9 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 62058000.0 12933000.0 19710000.0 29415000.0 False True 16955288.24335015 16769344.828978265 26371417.968603972 1.0 0.9890333085640811 1.555350613337218 24.015231974892608 -6.902488289711388 0.9454336362270284 0.9780345278110447 1.6178859795577394 0.9877630654488809 0.029250050480661722 0.10959637946516312 0.16728361845387252 0.023091347345368773 0.06086352380608361 1.251733024225835e-07 6.902488289711388 0.6398514517466947 EGEFVAQFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGEFVAQFK 9 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 41311400.0 11305000.0 5822400.0 24184000.0 False True 10946128.963044126 8147314.683414885 17849484.89555152 1.0 0.7443101310903166 1.6306664169419367 23.38391742324288 -6.829547905162278 1.3298476145581777 0.8633281222597785 1.6543106245261483 0.9049745226995369 0.11482478451811741 0.18137633687737523 0.6274762666749408 0.06779544339570824 0.15602589623429505 1.480648922225005e-07 6.829547905162278 0.7909825022663698 EGEFVAQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGEFVAQFK 9 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 54319000.0 12933000.0 23250000.0 18136000.0 False True 17714679.601183467 22222738.122531526 13852650.322644513 1.0 1.2544815160555818 0.781987065784642 24.0784420364155 -6.760383145420545 1.6107529494559498 1.1477418662620187 0.7802103909572293 0.6926688988597507 0.1070422214108901 0.2822568012727492 1.4433777861240566 0.0524283809056613 0.12595986322325373 1.7362683736127426e-07 6.760383145420545 -0.36753147530478936 EGEFVAQFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGEFVAQFK 9 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 23144000.0 11305000.0 5762900.0 6076100.0 False True 9400608.396416457 5731854.113853914 7346584.4172878 1.0 0.6097322505252868 0.7815009526498671 23.164322698677157 -10.091533863416412 5.063556824664839 1.000007644534508 0.6956166015866591 0.8072066167236104 0.07012427900074614 6.051848020449592e-06 1.085825181475414e-06 0.06789924546015529 0.02263251372743375 8.099647835117621e-11 10.091533863416412 -0.304391042947849 EGEK(ub)TSYVLTDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGEKTSYVLTDR 12 1 Q9NTJ4-2;Q9NTJ4;Q9NTJ4-4;Q9NTJ4-3;H3BMJ3;H3BUW3;H3BRI3;H3BQH9;B4DH23;H3BSE5 Q9NTJ4-2 MAN2C1 Alpha-mannosidase 2C1 1 4806120.0 740820.0 1524200.0 2541100.0 True False 971222.1941110862 1296795.3012850655 2278171.347952388 1.0 1.3352200033607768 2.345674719714875 19.8894418644902 -6.951343971703325 0.5438924862199918 0.9854925901533539 2.7423769901093333 0.999302553865231 0.015104975907212884 0.08295058746505204 0.03376381739847043 0.016526348106306984 0.08373370059097222 1.1185516126867802e-07 6.951343971703325 1.7568843999559793 up EGEK(ub)TSYVLTDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGEKTSYVLTDR 12 1 Q9NTJ4-2;Q9NTJ4;Q9NTJ4-4;Q9NTJ4-3;H3BMJ3;H3BUW3;H3BRI3;H3BQH9;B4DH23;H3BSE5 Q9NTJ4-2 MAN2C1 Alpha-mannosidase 2C1 1 34612800.0 4300700.0 8324100.0 21988000.0 True False 6524476.323285328 6838599.318509856 17642062.162317246 1.0 1.0481453192041557 2.7039813294063393 22.637430680030725 -6.9131148859126785 0.8742412079903022 0.9536433733349925 2.9328749236544986 0.9920451842878918 0.07065260862064127 0.10239444273973128 0.1278562850113389 0.05875023780703812 0.16590332429675664 1.2214764946389097e-07 6.9131148859126785 1.9792315503195061 up EGEK(ub)TSYVLTDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGEKTSYVLTDR 12 1 Q9NTJ4-2;Q9NTJ4;Q9NTJ4-4;Q9NTJ4-3;H3BMJ3;H3BUW3;H3BRI3;H3BQH9;B4DH23;H3BSE5 Q9NTJ4-2 MAN2C1 Alpha-mannosidase 2C1 1 4869320.0 740820.0 1299700.0 2828800.0 True False 1014721.1739077365 1242274.9564668497 2160695.700964756 1.0 1.2242525221808405 2.129349181355722 19.95265192601309 -6.944668348251265 0.6145985877892192 0.9900464286335209 2.411063451748803 0.9987136475206435 0.017509112631246066 0.08569993607516968 0.0453855647378629 0.017720970077454417 0.07644565396797341 1.1358779049517775e-07 6.944668348251265 1.4210170231152823 up EGEK(ub)TSYVLTDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGEKTSYVLTDR 12 1 Q9NTJ4-2;Q9NTJ4;Q9NTJ4-4;Q9NTJ4-3;H3BMJ3;H3BUW3;H3BRI3;H3BQH9;B4DH23;H3BSE5 Q9NTJ4-2 MAN2C1 Alpha-mannosidase 2C1 1 4054050.0 838390.0 2530200.0 685460.0 True False 697158.4319744896 2516569.3103946215 828786.5167910503 1.0 3.6097523819187023 1.1888065592834676 19.411127025868165 -6.628382889708129 2.086131879055713 2.7213653308523904 1.1984590987962347 0.11172807530489393 1.1199036136678164 0.5632630510632972 4.669110093730586 0.43937162533878565 1.2408680820773226 2.3529739023496213e-07 6.628382889708129 -1.5229062320561557 EGEK(ub)TSYVLTDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGEKTSYVLTDR 12 1 Q9NTJ4-2;Q9NTJ4;Q9NTJ4-4;Q9NTJ4-3;H3BMJ3;H3BUW3;H3BRI3;H3BQH9;B4DH23;H3BSE5 Q9NTJ4-2 MAN2C1 Alpha-mannosidase 2C1 1 25606800.0 4300700.0 5395600.0 15910500.0 True False 5567340.9294710085 5095330.116886414 13014952.255516151 1.0 0.915217907693423 2.337732217299793 22.408557002123175 -6.89273887115262 1.0060166774481343 0.9285094203169835 2.4668652229283885 0.9825949881603905 0.0859532902011728 0.11694995133913472 0.20908114570097197 0.06485368693701855 0.1633635493604253 1.2801507908462984e-07 6.89273887115262 1.538355802611405 up EGEPNLDKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGEPNLDKK 9 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 3615190.0 635590.0 1030200.0 1949400.0 True False 822783.7843519611 972868.4643814191 1594629.202533118 1.0 1.1824108385262688 1.938090216239587 19.65015383555107 -6.944070595301509 0.6205481768402974 0.9917324500073541 2.1688401788384355 0.9986498383592658 0.01492237812837042 0.08595787115587288 0.04651641441819508 0.015020484702964155 0.0639664643736364 1.1374423776157697e-07 6.944070595301509 1.1771077288310814 EGESLEDLMK(ub)LSPEELLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGESLEDLMKLSPEELLLR 19 1 P13796 P13796 LCP1 Plastin-2 1 20965100.0 8116000.0 9323200.0 3525900.0 True False 7858362.022473785 13046002.37984572 2602361.015267329 1.0 1.6601427043620578 0.33115819910370003 22.90579720136065 -6.771629176511056 1.568081232872781 1.3778476449998533 0.3231934533351503 0.7368097028175594 0.2783442990899477 0.26379891144768947 1.2803325658077045 0.13989215261208846 0.33252471880853063 1.691884935487263e-07 6.771629176511056 -1.054654191664703 EGESLEDLMK(ub)LSPEELLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGESLEDLMKLSPEELLLR 19 1 P13796 P13796 LCP1 Plastin-2 1 17975400.0 8116000.0 6367800.0 3491600.0 True False 6748813.59976258 6333495.397490658 4221677.416665641 1.0 0.9384605610849094 0.6255436387832903 22.686202476794925 -6.939431069802332 0.664839181182626 1.0035491986263048 0.542554787997331 0.9980883688752855 0.007168330762415087 0.08802727621402982 0.055799697880829655 0.006948085971586668 0.027000376388367515 1.1496587000620338e-07 6.939431069802332 -0.4609944106289737 EGFEK(ub)ISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGFEKISK 8 1 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 5684400.0 2023800.0 1589700.0 2070900.0 True False 2653221.3985070814 1352522.9566020672 1856623.1334755046 1.0 0.5097663381439284 0.6997618572352055 21.33931363584488 -10.133146147779165 5.243876086371196 1.000011250768847 0.6047640976892662 0.8522863180657205 0.0775653458658597 1.0202761722967057e-05 1.6864862348517938e-06 0.07510445931472988 0.025034107731622884 7.35959392458174e-11 10.133146147779165 -0.3952471530795808 EGFEK(ub)ISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGFEKISK 8 1 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 9777800.0 2446400.0 2463800.0 4867600.0 True False 2368740.3710916555 3447608.1885472643 3592629.5351301064 1.0 1.4554605606516526 1.516683541588144 21.175688648077433 -11.845455985895072 0.3273805814053645 7.401363584702633e-12 1.5290231930017177 0.9995203274013477 0.005048182197571738 4.821331311376505 0.1740567286027793 3.333434475918114 0.019794712891890595 1.4273944838728031e-12 11.845455985895072 1.5290231929943163 EGFEK(ub)ISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGFEKISK 8 1 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 28292700.0 10005000.0 8458100.0 9829600.0 True False 15178316.463475624 6948685.971563075 7886775.251533267 1.0 0.45780347170149344 0.5196080389094289 23.855508444128986 -10.169110566564092 5.310829382780612 1.0000197678249796 0.48870575530690485 0.9891600523256207 0.02523160890612928 5.9059056567359326e-06 9.239476062316675e-07 0.02443134315306133 0.008143466757530415 6.77469009548553e-11 10.169110566564092 -0.5113140125180747 EGFEK(ub)ISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGFEKISK 8 1 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 5344700.0 2023800.0 1390600.0 1930300.0 True False 2772053.5511385724 1329158.6939007454 1474402.8957763938 1.0 0.4794852153396592 0.531881101348424 21.402523697367773 -10.700360537225462 10.47955563966821 1.0003580279937996 0.5056831588293668 0.9916439577436081 0.021390530890417682 0.00017904638387935225 5.119447726337086e-06 0.020724745818133068 0.006903764158760256 1.9936066001155844e-11 10.700360537225462 -0.4946748691644328 EGFEK(ub)ISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGFEKISK 8 1 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 9255200.0 2446400.0 4411300.0 2397500.0 True False 2034289.9938959072 4387535.451325502 2898806.165212478 1.0 2.1567895749823016 1.4249719429927095 20.95609392351171 -10.089225969820717 4.76399049768798 0.9999658814906929 1.7908807589912668 0.6089531109351989 0.2987632972295498 37873970.081447445 80209874.41021831 8960.260033727445 0.10227462806638689 8.14280491634867e-11 10.089225969820717 0.7909148775005739 EGFEK(ub)ISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGFEKISK 8 1 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 26971900.0 10005000.0 7733400.0 9233500.0 True False 12951669.728034357 7303029.49179505 7553097.743710649 1.0 0.563867798140913 0.5831755983834035 23.626634766221436 -10.670656660482186 10.313376872855617 1.0001711019500177 0.5735216982684584 0.9984651493557064 0.00788237644161449 3.102287670408672e-05 9.906714417247582e-07 0.00763501394731824 0.0025440260572425484 2.1347318979198026e-11 10.670656660482186 -0.42664940368155924 EGFTFEYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGFTFEYR 8 0 H7C5J4;A0A0G2JPP0;O75175 H7C5J4 CNOT3 CCR4-NOT transcription complex subunit 3 0 3714890.0 922680.0 976210.0 1816000.0 False True 1263819.7304894445 933077.8143052271 1387098.2016940035 1.0 0.7382997683885426 1.0975443476870048 20.269359263475017 -6.711339758445164 1.7901419769516365 0.8393376141702671 1.0967453035582315 0.47161328446965356 0.11025576437677494 0.3723793956317312 2.3269501822870335 0.048994970668647095 0.12428182214632329 1.943838777363766e-07 6.711339758445164 0.25740768938796443 EGFVVK(ub)VR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGFVVKVR 8 1 P55795 P55795 HNRNPH2 Heterogeneous nuclear ribonucleoprotein H2 1 15068800.0 4902400.0 6710000.0 3456400.0 True False 6427093.874909127 5708894.155375139 3098764.884129963 1.0 0.8882543598222855 0.48214090916382896 22.615735114030553 -6.947079750016102 0.5900351280116166 1.0046935587022925 0.34526546458621254 0.9989517211242336 0.007204209439736671 0.08468003291878266 0.04098212047527792 0.007468595427176142 0.03402253860868518 1.1295884679426454e-07 6.947079750016102 -0.6594280941160799 down EGFVVK(ub)VR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGFVVKVR 8 1 P55795 P55795 HNRNPH2 Heterogeneous nuclear ribonucleoprotein H2 1 27784600.0 6330100.0 5897500.0 15557000.0 True False 8194439.234925577 5569298.940680858 12725785.628299847 1.0 0.6796436926329149 1.5529782165033559 22.966213794954864 -6.807396792708582 1.425248627122343 0.8248654768967053 1.5673949809080334 0.852986296351437 0.13831188949755233 0.2103611676148593 0.8426414950168 0.07631409787342759 0.17676374218991342 1.5581282700035591e-07 6.807396792708582 0.7425295040113281 EGGFLLLHTLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGGFLLLHTLLR 12 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 39196000.0 7591100.0 19308000.0 12296900.0 False True 9952005.61231698 16427321.661994541 11024534.748193998 1.0 1.650654380827867 1.1077701498228272 23.246555868383886 -10.404771450487402 3.770203807218147 0.9978731173715132 1.37921226527057 0.39414593391302477 0.22163156025067515 79465009.35054828 4416.301946780113 1490949.6441316246 0.07587017727038049 3.9375723753818304e-11 10.404771450487402 0.3813391478990569 EGGFLLLHTLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGGFLLLHTLLR 12 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 42874300.0 19550600.0 13136700.0 10187000.0 False True 18929976.90445739 18382252.816985488 7518719.096550739 1.0 0.9710657815254422 0.39718585682903434 24.174169315092293 -6.917370468818557 0.8440007511655138 1.0139018172742245 0.3100177298773654 0.9934186901769884 0.02252044645339091 0.0997439502543315 0.11381451813552808 0.0191381522389294 0.05596267480888751 1.2095658901194055e-07 6.917370468818557 -0.703884087396859 down EGGFLLLHTLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGGFLLLHTLLR 12 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 78281700.0 20207700.0 29336000.0 28738000.0 False True 30656558.28075725 24100761.596785847 23057921.703687165 1.0 0.7861535328286869 0.752136671459312 24.86969240328273 -13.999999999459316 0.2587530540722928 2.555333733843945 0.739554434071737 0.9995597973668296 0.0023017885034299843 14.362402838061037 0.16096758209933495 11.671705221071534 0.014970059062105148 1.0000000012449708e-14 13.999999999459316 -1.8157792997722078 EGGFLLLHTLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGGFLLLHTLLR 12 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 80637100.0 7591100.0 24331000.0 48715000.0 False True 10397734.811764015 23255975.96814256 37209520.3169181 1.0 2.236638689979928 3.5786179384782137 23.309765929906778 -6.970079851938207 0.2562737960999455 0.6056775598656869 5.249201220146459 0.9999829982636563 0.004341885742423228 0.0762768182246101 0.008937487937851336 0.02870297861882353 0.12733876501688718 1.0713223075060019e-07 6.970079851938207 4.6435236602807715 EGGFLLLHTLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGGFLLLHTLLR 12 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 35748100.0 19550600.0 7006700.0 9190800.0 False True 16257190.138432538 6968953.51637894 11112553.78654215 1.0 0.42866900473188796 0.683547014700388 23.95457459052657 -10.381601279444743 5.956123731300626 1.000092048775093 0.556108009716145 0.8017510410868625 0.10405351184647277 0.00012721254325032054 1.320769709571166e-05 0.10077011029835954 0.03358312654131526 4.153351818972027e-11 10.381601279444743 -0.443984039058948 EGGFLLLHTLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGGFLLLHTLLR 12 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 52223600.0 20207700.0 15846600.0 16169300.0 False True 26159266.00331832 14964722.779719088 13226653.311028378 1.0 0.5720620287213258 0.505620200098526 24.64081872537518 -13.999999999999998 0.26220798177633825 4.169104447229665 0.4818448538426001 0.9995668715237942 0.0045593919575935915 14.515869006125227 0.16204962760017244 24.407567604179356 0.028713553566657918 1.0000000000000041e-14 13.999999999999998 -3.687259593387065 EGGQVYGTLGGMLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGGQVYGTLGGMLTR 15 0 A2ACR1;P28065-2;P28065;A0A0G2JJA7;A2ACR0;A0A0G2JJQ0;A0A0G2JJ13;A0A0G2JHI2 A2ACR1 PSMB9 Proteasome subunit beta type;Proteasome subunit beta type-9 0 5590100.0 1740200.0 1656600.0 2193300.0 False True 2281419.0521207713 1409441.7373762252 1966358.3556192124 1.0 0.6177916924407335 0.8619014353331171 21.121500035215686 -10.71774725065039 5.995237744813779 1.0052851489177923 0.7398465638869384 0.6022836570779873 0.09965738522138876 0.007145098666772259 0.0003363873172412523 0.09793286213166988 0.03216428277408464 1.915370301960157e-11 10.71774725065039 -0.26543858503085394 EGGSIPVTLTFQEATGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGGSIPVTLTFQEATGK 17 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 50182000.0 10714000.0 18511000.0 20957000.0 False True 14046157.754523594 15749230.955312843 18788570.673739042 1.0 1.1212483321455484 1.3376306177173714 23.7436722077126 -6.962210580193296 0.40307326853025754 0.9885009804704062 1.4783182627575358 0.9998435966813541 0.0017464606567329031 0.07892074058794225 0.01828176275534584 0.002783650031472482 0.01810895040751126 1.0909112484350583e-07 6.962210580193296 0.4898172822871295 EGGSIPVTLTFQEATGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGGSIPVTLTFQEATGK 17 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 58850300.0 16136000.0 9450300.0 33264000.0 False True 15623771.512399832 13223854.072663443 24551160.501390412 1.0 0.8463932067982631 1.571397820424175 23.897239420216952 -6.851334883745002 1.2286098596641555 0.9179269741052613 1.6011396283286834 0.942230864781928 0.07497385784569678 0.15599195845189429 0.4524432843405039 0.047733666148074685 0.11055834166983132 1.408202517066934e-07 6.851334883745002 0.6832126542234221 EGGSIPVTLTFQEATGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGGSIPVTLTFQEATGK 17 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 107883900.0 5806900.0 91982000.0 10095000.0 False True 8809491.841255043 75567093.44135381 8099718.825204322 1.0 8.577917410340454 0.9194308787793142 23.070627371756448 -6.648605574799394 2.0133635053681584 5.922799920013486 0.951547388503887 0.1883943171970519 3.235467040865971 0.5120141285789326 3.9766383402312653 1.3039536235501312 3.583787179254938 2.2459207376147092e-07 6.648605574799394 -4.971252531509599 EGGSIPVTLTFQEATGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGGSIPVTLTFQEATGK 17 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 52948000.0 10714000.0 19423000.0 22811000.0 False True 14675255.334963258 18564827.636728164 17423511.6072918 1.0 1.2650429047389822 1.1872714450004096 23.80688226923549 -10.101817786641359 4.351420905648132 0.9999758708042692 1.2261571747935065 0.918534019628372 0.03175006562688102 22104766.98225558 0.12169236408456338 6185.402342567509 0.010868891944458343 7.910104361213661e-11 10.101817786641359 0.2261813039892373 EGGSIPVTLTFQEATGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGGSIPVTLTFQEATGK 17 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 31289400.0 16136000.0 7558200.0 7595200.0 False True 13417798.94600407 7517482.476414764 9183321.20376301 1.0 0.5602619704369272 0.6844133855872 23.677644695651228 -10.416530423851432 8.874380095768906 1.0000025071069791 0.6223376780120677 0.9250259109780375 0.05068460299376823 2.5141608700373674e-06 1.653029002844373e-07 0.04907548184756896 0.01635838527533326 3.832388922313065e-11 10.416530423851432 -0.3776648290949114 EGGSIPVTLTFQEATGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGGSIPVTLTFQEATGK 17 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 26422900.0 5806900.0 11788000.0 8828000.0 False True 7517146.521111724 11131987.437515207 7221394.5829292955 1.0 1.4808794010135746 0.9606563557924784 22.841753693848897 -6.663755369676821 1.959184525039717 1.3085623071769255 0.962788934671704 0.2518976399274053 0.20456278138210796 0.47557104440488374 3.5128376070522633 0.08423454544897059 0.22692907071304014 2.1689254777733633e-07 6.663755369676821 -0.34577337250522144 EGGSIPVTLTFQEATGK(ub)NVMLLPVGSADDGAHSQNEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEK 37 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 1 15292700.0 3872800.0 4287900.0 7132000.0 True False 3749860.0838635396 6000080.831103104 5263915.244586235 1.0 1.6000812555441073 1.4037631076524701 21.838405335577484 -10.060643569213191 4.413915214149496 0.9999654914571368 1.501922181594419 0.897071329576765 0.08014654843196112 11744421.435028516 8923026.867378186 3586.45832512566 0.027436296479327132 8.696738884584593e-11 10.060643569213191 0.5019566901372823 EGGSIPVTLTFQEATGK(ub)NVMLLPVGSADDGAHSQNEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEK 37 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 1 72553000.0 7880000.0 11119000.0 53554000.0 True False 11954536.105166204 9134727.576856483 42969028.42644791 1.0 0.7641222960470102 3.5943702079647126 23.51105481167962 -6.886665798596169 1.041868274998336 0.8355522319601875 3.8225035183445497 0.9786783757947003 0.187228215037094 0.12189161529367729 0.2379655149079144 0.13748501730588011 0.3388972121979955 1.298177869853216e-07 6.886665798596169 2.9869512863843624 up EGGSIPVTLTFQEATGK(ub)NVMLLPVGSADDGAHSQNEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGGSIPVTLTFQEATGKNVMLLPVGSADDGAHSQNEK 37 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 1 13768900.0 3872800.0 5026900.0 4869200.0 True False 3220404.794130179 4999819.091938476 5887327.20736292 1.0 1.5525436743392103 1.8281326676987102 21.61881061101176 -10.373813229315449 0.14665900324448464 1.2032518260414838e-17 2.2377533323165517 0.9997145345040537 0.005817672352539717 2.1297522314068322 0.07527417276217614 1.0352851771324432 0.2578848502281066 4.228504242744516e-11 10.373813229315449 2.2377533323165517 EGHWSK(ub)ECPIDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGHWSKECPIDR 12 1 Q9BWF3 Q9BWF3 RBM4 RNA-binding protein 4 1 5900700.0 1385300.0 1408700.0 3106700.0 True False 1341324.409774882 1971201.2562734543 2292962.0709977658 1.0 1.469593218395456 1.709476137381709 20.355226775821745 -10.62699003125592 0.132129221548661 1.3870442237179833e-17 2.1217832139689614 0.9997717478186545 0.004451717046917482 2.5774460050830488 0.07253923317899924 1.0810240116252974 0.2640621092649496 2.3605324159401102e-11 10.62699003125592 2.1217832139689614 EGHWSK(ub)ECPIDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGHWSKECPIDR 12 1 Q9BWF3 Q9BWF3 RBM4 RNA-binding protein 4 1 24112000.0 2359800.0 4120200.0 17632000.0 True False 3579989.1244887337 3384918.1187304687 14147027.47161985 1.0 0.9455107267159301 3.951695655958234 21.771523774112588 -6.9027730848956566 0.9435684498905548 0.8843449418532211 4.285637678306825 0.9878962141131197 0.1545149979801796 0.10939280301862345 0.16613055944954283 0.12214726087905155 0.32246506141273723 1.250912450417892e-07 6.9027730848956566 3.401292736453604 up EGHWSK(ub)ECPIDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGHWSKECPIDR 12 1 Q9BWF3 Q9BWF3 RBM4 RNA-binding protein 4 1 5696200.0 1385300.0 1237200.0 3073700.0 True False 1151938.3291955532 1230534.9580350271 3716396.458816925 1.0 1.0682298929095981 3.2262113037008158 20.13563205125602 -6.9136361486574405 0.8705993632790533 0.9406207781252253 3.527931137839475 0.9922230883815303 0.09116217635664749 0.10206254530658905 0.12608524339916624 0.0760043553569342 0.2154905467184504 1.2200112947265976e-07 6.9136361486574405 2.58731035971425 up EGHWSK(ub)ECPIDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGHWSKECPIDR 12 1 Q9BWF3 Q9BWF3 RBM4 RNA-binding protein 4 1 30002700.0 2359800.0 3071900.0 24571000.0 True False 3054807.6186122415 2900946.064582873 20099330.11975031 1.0 0.9496329807834951 6.579573128366483 21.542650096205037 -6.904879922569568 0.9298829969998684 0.7962237195579618 7.232806883744696 0.9888421139461034 0.27909664488246905 0.10790243960387648 0.1578470371756545 0.22286666215445633 0.5954428017111191 1.2448587533246617e-07 6.904879922569568 6.436583164186734 up EGIAASFAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGIAASFAVK 10 0 E7ETZ4;Q9Y6E2;Q75MG1;B5MCH7;E9PFD4;E7EMS9 E7ETZ4 BZW2 Basic leucine zipper and W2 domain-containing protein 2 0 8317100.0 2329300.0 3089600.0 2898200.0 False True 3053734.856973287 2628643.7231664727 2598322.0654974664 1.0 0.8607963186993438 0.8508669505357109 21.542143373719707 -13.999999999999998 0.3748396144025144 2.999011615092673 0.8499146611411001 0.9997990616593254 0.0009650693402291342 23.395927744626263 0.19916807963612962 37.65847506345425 0.0027337153982008957 1.0000000000000041e-14 13.999999999999998 -2.149096953951573 EGIAASFAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGIAASFAVK 10 0 E7ETZ4;Q9Y6E2;Q75MG1;B5MCH7;E9PFD4;E7EMS9 E7ETZ4 BZW2 Basic leucine zipper and W2 domain-containing protein 2 0 6241900.0 2329300.0 2039400.0 1873200.0 False True 3190505.156965644 1949292.564606056 1430788.7397649812 1.0 0.6109667493720482 0.44845210064657737 21.6053534352426 -13.999999999999998 0.11966183658099284 2.8546630607809655 0.18788314999058478 0.9996946026390424 0.004044061738694052 11.965067987231617 0.10641695739573305 5.279626287632459 0.23122088137662275 1.0000000000000041e-14 13.999999999999998 -2.666779910790381 EGICAIGGTSEQSSVGTQHSYSEEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGICAIGGTSEQSSVGTQHSYSEEEK 26 0 P13796;Q5TBN3 P13796 LCP1 Plastin-2 0 67261100.0 6958100.0 36794000.0 23509000.0 False True 9122136.482336257 31304478.621888716 21076514.194251593 1.0 3.4317046979625294 2.3104800322888526 23.120940324799022 -10.39723852681381 19.45793162596921 0.9999593426290677 2.871092365125691 0.7878282156732545 0.45773805358907543 0.0 0.0 0.44320296434701334 0.14773432144900442 4.0064661073716066e-11 10.39723852681381 1.8711330224966232 EGICAIGGTSEQSSVGTQHSYSEEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGICAIGGTSEQSSVGTQHSYSEEEK 26 0 P13796;Q5TBN3 P13796 LCP1 Plastin-2 0 20657100.0 11724000.0 1984600.0 6948500.0 False True 11351828.037393136 2777061.129552275 5128479.39946823 1.0 0.244635588242227 0.4517756420001186 23.436421304293532 -10.109781054279427 5.343125568442029 1.0000114171841088 0.3482056151227177 0.9295861863408454 0.0845645728346717 1.1501419913009402e-05 1.9161423157189447e-06 0.08188072874968838 0.027293098522113864 7.766385534059931e-11 10.109781054279427 -0.651805802061391 EGICAIGGTSEQSSVGTQHSYSEEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGICAIGGTSEQSSVGTQHSYSEEEK 26 0 P13796;Q5TBN3 P13796 LCP1 Plastin-2 0 49277100.0 6958100.0 20035000.0 22284000.0 False True 9530697.605582219 19149787.453114834 17020978.153386105 1.0 2.009274477651943 1.7859110484647795 23.184150386321914 -10.02227243764535 5.197950685664607 0.999992572776797 1.8975927630615934 0.9556175927730775 0.09118773812908623 7.85013459693352e-06 1.476670704222205e-06 0.08829287857141375 0.029430715927732703 9.500086559461255e-11 10.02227243764535 0.8976001902847964 EGICALGGTSELSSEGTQHSYSEEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGICALGGTSELSSEGTQHSYSEEEK 26 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 19257400.0 1003000.0 8039400.0 10215000.0 False True 1314942.7130658159 6839952.857335749 9158049.789199034 1.0 5.201711671064558 6.964599824920778 20.32656851760514 -8.893491244348114 0.37150566736768154 3.73073590364769e-18 7.405584212153589 0.9977384070992373 0.11898412247474435 0.3936191608650403 0.12936344677890838 1.0899367334579324 0.4744054840371018 1.2779349732852286e-09 8.893491244348114 7.405584212153589 EGICALGGTSELSSEGTQHSYSEEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGICALGGTSELSSEGTQHSYSEEEK 26 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 13574900.0 1003000.0 7367600.0 5204300.0 False True 1373836.2050558273 7042075.070604877 3975151.5259229634 1.0 5.125847640853747 2.893468312520872 20.38977857912803 -10.456322598616751 7.034384099694677 0.9995490987355273 4.0096579766873095 0.707898421771862 0.911365044458763 0.006445306187242979 0.0004981446337712292 0.8825102524731864 0.2941418032920308 3.4968532051113916e-11 10.456322598616751 3.010108877951782 EGIILFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGIILFK 7 0 P05455 P05455 SSB Lupus La protein 0 13393800.0 2629300.0 4500400.0 6264100.0 False True 3447037.762177422 3828957.862421804 5615951.02149013 1.0 1.1107966104795821 1.629210762676023 21.716925672789348 -6.941296340174952 0.6473968169966515 0.9942861925032432 1.7745055890868686 0.9983287493542984 0.011211741205257579 0.08718027992994438 0.05195474824867257 0.0110240906227121 0.0443702477021413 1.1447315690578217e-07 6.941296340174952 0.7802193965836254 EGIILFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGIILFK 7 0 P05455 P05455 SSB Lupus La protein 0 10443400.0 3652200.0 1337800.0 5453400.0 False True 3536262.9101132043 1871990.5165348393 4024990.9415068068 1.0 0.5293697228170494 1.138204665155385 21.7537941079156 -6.700312856406834 1.8298323245875505 0.707842987578798 1.136398470431888 0.41900020087662815 0.198648127642503 0.39488643739392487 2.570770494175766 0.08660191694124869 0.2226248163111184 1.9938254884896504e-07 6.700312856406834 0.42855548285308986 EGINIFLDGYVPTENLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGINIFLDGYVPTENLR 17 0 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 51510200.0 9903200.0 26797000.0 14810000.0 False True 15023878.42089874 22014865.98408338 11882797.00854641 1.0 1.4653250889903324 0.7909273940886679 23.840753957510472 -6.721049652272541 1.7553550364440662 1.282778265679524 0.7919033998705134 0.5175325147032002 0.19578584639629112 0.353290662560575 2.1279725732534907 0.08853845793860704 0.22200610465105267 1.9008609447622196e-07 6.721049652272541 -0.4908748658090105 EGINIFLDGYVPTENLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGINIFLDGYVPTENLR 17 0 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 30808500.0 9903200.0 7160300.0 13745000.0 False True 12819887.621256365 6761823.010590443 11243551.035609785 1.0 0.5274479161095623 0.8770397500963354 23.61188027960292 -10.281205846791343 5.834983006417533 1.00001904184808 0.702243833102948 0.4916756041240553 0.14272026858523265 3.535613679780392e-05 4.355344311070432e-06 0.13819713503624892 0.046062768616403744 5.233523193859587e-11 10.281205846791343 -0.2977752087451321 EGISFHFTPVLVCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGISFHFTPVLVCK 14 0 Q9BRR6-2;Q9BRR6;Q9BRR6-4;Q9BRR6-3 Q9BRR6-2 ADPGK ADP-dependent glucokinase 0 10657700.0 5989200.0 4668500.0 0.0 False True 7851899.199495299 3971977.9976704735 0.0 1.0 0.5058620719336008 0.0 22.904610221328245 -7.910662702223506 0.596564376313683 1.0096599111726685 2.7558848995701387e-18 0.9888592288729056 0.04309153316474135 0.11289525319452284 0.16077443823599846 0.044592450857733376 0.07716881819622629 1.2283929005121902e-08 7.910662702223506 -1.0096599111726685 down EGISFHFTPVLVCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGISFHFTPVLVCK 14 0 Q9BRR6-2;Q9BRR6;Q9BRR6-4;Q9BRR6-3 Q9BRR6-2 ADPGK ADP-dependent glucokinase 0 7450900.0 3414200.0 2126000.0 1910700.0 False True 3305818.0898385933 2974922.8869435387 1410230.3502286759 1.0 0.8999051992872329 0.42659042690928295 21.656575908561685 -6.941057473687629 0.6496535903916737 1.0052310782205243 0.29488241281194916 0.998299123737527 0.01031357437925538 0.08728756792728977 0.052437966032614365 0.010121812714643956 0.04055122643495167 1.145361356519761e-07 6.941057473687629 -0.7103486654085751 down EGISFHFTPVLVCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGISFHFTPVLVCK 14 0 Q9BRR6-2;Q9BRR6;Q9BRR6-4;Q9BRR6-3 Q9BRR6-2 ADPGK ADP-dependent glucokinase 0 18330900.0 5989200.0 4493500.0 7848200.0 False True 8203569.092044229 4294962.311982596 5994616.798752677 1.0 0.5235480147473646 0.7307327739296082 22.967820282851136 -10.276020437805588 5.651528171186598 1.0000301963496014 0.6271403943384807 0.8119703371662663 0.08458282374633898 3.21838825030885e-05 4.1230726634600626e-06 0.0819035871048954 0.027298988978727616 5.2963851862957496e-11 10.276020437805588 -0.37288980201112076 EGISFHFTPVLVCKDPIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGISFHFTPVLVCKDPIR 18 1 Q9BRR6-2;Q9BRR6;Q9BRR6-4;Q9BRR6-3 Q9BRR6-2 ADPGK ADP-dependent glucokinase 0 3512170.0 999970.0 1327000.0 1185200.0 False True 1310970.3537232545 1129016.7726054876 1062566.8732411829 1.0 0.861206944458351 0.8105193761425749 20.322203630154593 -13.999999999999998 0.14007351278573169 1.6630336565453796 0.7478463770065732 0.9996026359267176 0.0015965856850247225 11.934059991476595 0.11726560835361807 2.1626879003734945 0.056031561176960794 1.0000000000000041e-14 13.999999999999998 -0.9151872795388064 EGISFHFTPVLVCKDPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGISFHFTPVLVCKDPIR 18 1 Q9BRR6-2;Q9BRR6;Q9BRR6-4;Q9BRR6-3 Q9BRR6-2 ADPGK ADP-dependent glucokinase 0 5482770.0 999970.0 1702400.0 2780400.0 False True 1369685.9321731564 1627182.3389160293 2123726.7841354674 1.0 1.1879966791615701 1.550520987512767 20.385413691677485 -6.960752519646013 0.42470261429370576 0.9847642090312541 1.7675346574499189 0.9997970804636024 0.003254730090116253 0.07943349871253809 0.02014677448002499 0.0047053398636562015 0.030139604910516225 1.0945799290215482e-07 6.960752519646013 0.7827704484186648 EGIVALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGIVALR 7 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 6532240.0 2262400.0 943040.0 3326800.0 False True 2190581.3503751503 1319600.7898886343 2455411.2781393006 1.0 0.6023975277898923 1.1208948153049858 21.06288236152603 -6.701844614611689 1.824573629530466 0.7535495159315976 1.1193929487073324 0.42623371469729365 0.16777707624014448 0.3916838476243947 2.536378955794525 0.07332851367120334 0.18813362855205537 1.986805645579616e-07 6.701844614611689 0.36584343277573483 EGK(ub)PLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGKPLLK 7 1 P13639 P13639 EEF2 Elongation factor 2 1 14128600.0 5287100.0 4902800.0 3938700.0 True False 6931439.300349228 4171321.350964712 3531161.106678242 1.0 0.6017972848372989 0.509441250751533 22.72472352570882 -13.999999999999998 0.2053033347279409 3.259655341921242 0.4525007222343219 0.9994879186926737 0.004816605889820209 12.640818682622555 0.1436453828185161 11.496669436937939 0.05656444352858358 1.0000000000000041e-14 13.999999999999998 -2.80715461968692 EGK(ub)PLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGKPLLK 7 1 P13639 P13639 EEF2 Elongation factor 2 1 14621100.0 3132900.0 3738200.0 7750000.0 True False 4752838.345669449 3071089.0033100923 6218209.103054336 1.0 0.6461589433413649 1.3083148743571429 22.180357902614517 -6.761571917646278 1.6068585387550893 0.7948683614177842 1.3108977987977928 0.6972361747843496 0.1488601783729271 0.2802845732388576 1.4267239265370306 0.07308645935851651 0.17534529321494322 1.7315222729792297e-07 6.761571917646278 0.5160294373800086 EGK(ub)PLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGKPLLK 7 1 P13639 P13639 EEF2 Elongation factor 2 1 13493200.0 5287100.0 3682200.0 4523900.0 True False 7241883.74850515 3519508.228592929 3455447.9926450946 1.0 0.48599347225359923 0.47714767492068055 22.787933587231713 EGK(ub)PLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGKPLLK 7 1 P13639 P13639 EEF2 Elongation factor 2 1 11930700.0 3132900.0 4104200.0 4693600.0 True False 4055600.808691543 3875797.662118244 3839412.960402912 1.0 0.9556654722555623 0.9466940020760131 21.951484224706967 -13.999999999999991 0.22459961322541905 1.2730563630493927 0.9421016495365376 0.9995028526136981 0.0005195662004165474 13.128702247897861 0.15009632374336485 1.5939088624865052 0.004818596836623146 1.0000000000000205e-14 13.999999999999991 -0.3309547135128551 EGK(ub)TDYYAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGKTDYYAR 9 1 P46777;A0A2R8Y4A2;R4GNJ2 P46777 RPL5 60S ribosomal protein L5 1 123728200.0 39323000.0 56358000.0 28047200.0 True False 38074712.889321916 78862043.30308743 20700796.92203576 1.0 2.071244595654045 0.5436888515012628 25.18232982200846 -6.718211094778613 1.7656970685151596 1.652981532086108 0.5463050482423236 0.5040424801482273 0.4508870437176611 0.35882898178551476 2.1853451117662366 0.20283279554967928 0.5102713153187358 1.9133257008141385e-07 6.718211094778613 -1.1066764838437844 EGK(ub)TDYYAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGKTDYYAR 9 1 P46777;A0A2R8Y4A2;R4GNJ2 P46777 RPL5 60S ribosomal protein L5 1 60530700.0 28315300.0 13396900.0 18818500.0 True False 42956380.225712255 11006118.524542559 15099015.226558423 1.0 0.2562161538451665 0.3514964516847408 25.35636909211501 -10.698834044724164 6.863366502343836 1.0059660453190908 0.3038563027938826 0.9861448760114073 0.03889801870789391 0.003549849624604915 0.000155767942008389 0.037650432669216305 0.012554281554678137 2.0006262151669134e-11 10.698834044724164 -0.7021097425252083 EGK(ub)TDYYAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGKTDYYAR 9 1 P46777;A0A2R8Y4A2;R4GNJ2 P46777 RPL5 60S ribosomal protein L5 1 115050100.0 39323000.0 71835000.0 3892100.0 True False 32698816.804271065 71448010.59686881 4705920.114962874 1.0 2.1850335143483357 0.14391713752615642 24.962735097442735 -6.749298741002866 1.6523983218840304 1.6973917916820866 0.1400646134310027 0.6459781866174559 0.4979423524009103 0.3012634104935492 1.6181944102436083 0.2380704390670157 0.5784063012733348 1.7811531324286547e-07 6.749298741002866 -1.557327178251084 EGK(ub)TDYYAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGKTDYYAR 9 1 P46777;A0A2R8Y4A2;R4GNJ2 P46777 RPL5 60S ribosomal protein L5 1 54471100.0 28315300.0 17741700.0 8414100.0 True False 36654714.0280071 16754358.798792275 6882820.135956659 1.0 0.4570860595445001 0.18777448736055177 25.12749541420746 -9.18011307239243 0.24017795120842506 1.364740546455943 6.547260746134008e-22 0.9992184487863385 0.009443684189170489 0.6105342699599906 0.08622665959473157 0.2968259737266145 0.11793583807785535 6.605214530420169e-10 9.18011307239243 -1.364740546455943 EGKPLLK(ub)AVMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGKPLLKAVMR 11 2 P13639 P13639 EEF2 Elongation factor 2 1 20743000.0 1461900.0 6644100.0 12637000.0 True False 2217809.1792058987 5458408.4444097625 10139291.411006134 1.0 2.461171364780888 4.571760053151451 21.080703810361992 -6.965876784081556 0.34267139955952536 0.7780458935397879 6.325311204417163 0.9999300947372652 0.012258612157035722 0.0776646767999149 0.013817825616223488 0.02955692973263228 0.182328060923827 1.0817408140083579e-07 6.965876784081556 5.547265310877376 EGKPLLK(ub)AVMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGKPLLKAVMR 11 2 P13639 P13639 EEF2 Elongation factor 2 1 16580700.0 1461900.0 6728700.0 8390100.0 True False 1892458.368357164 6354241.929997336 6863187.889695869 1.0 3.35766537126702 3.6265991392211054 20.85183013245444 -10.14214618229648 0.48651647269844567 2.629846688205955e-22 3.622307594931484 0.999313276088105 0.030920337204925485 1.4519298788031636 0.22476240413899617 2.0936055949350423 0.05590379701430617 7.208647972865956e-11 10.14214618229648 3.622307594931484 EGKPTIVEEDDPELFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGKPTIVEEDDPELFK 16 1 O75937 O75937 DNAJC8 DnaJ homolog subfamily C member 8 0 8376800.0 1723700.0 1164900.0 5488200.0 False True 1668982.0870056767 1630050.6448732484 4050675.777529186 1.0 0.97667354105503 2.4270337045956616 20.670537039826506 -6.903245650420338 0.9405167278839223 0.9449509268342112 2.589721928871523 0.9881131376122597 0.07395022267687026 0.10905563966565625 0.1642504923745872 0.05859092757157826 0.15508306344245 1.2495520449225e-07 6.903245650420338 1.644771002037312 up EGLELLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGLELLK 7 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 77334300.0 2204300.0 49511000.0 25619000.0 False True 2889858.646471565 42124151.79236644 22968191.634800777 1.0 14.576544027092407 7.947859893716353 21.46256749629861 -9.27705811737384 11.488263985493784 1.000000065476048 11.262201960400848 0.7616604131490814 2.7061489654757165 0.0 0.0 2.620217312733853 0.8734058229703218 5.283745398580594e-10 9.27705811737384 10.2622018949248 EGLELLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGLELLK 7 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 70387600.0 23998000.0 8021600.0 38368000.0 False True 23236196.62584104 11224666.712091375 28318269.78467253 1.0 0.4830681583925138 1.2187136406471832 24.469870607390856 -6.717840709024082 1.7668893209011725 0.684781775688308 1.2174438363627107 0.5023562127397473 0.2175869619149875 0.3595507202965276 2.1924646419326907 0.09782093520116009 0.24621117409561222 1.9149581665509973e-07 6.717840709024082 0.5326620606744027 EGLELLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGLELLK 7 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 91955300.0 2204300.0 53979000.0 35772000.0 False True 3019289.2789676595 51594029.29531745 27323390.347465783 1.0 17.088137150262803 9.049609965431356 21.525777557821502 -9.79534183259228 11.609039693094882 1.000000000714173 13.068873557845293 0.7503443603764248 3.2817149810547273 0.0 0.0 3.177506867156087 1.0591689557186954 1.601983974931849e-10 9.79534183259228 12.06887355713112 EGLELLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGLELLK 7 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 26076120.0 23998000.0 1153100.0 925020.0 False True 19955400.291658748 1146888.021427571 1118437.40519076 1.0 0.05747256405109369 0.05604685392646626 24.250275882825132 EGLELLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGLELLK 7 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 8717100.0 2381000.0 2802600.0 3533500.0 False True 3082251.4365267227 2646632.8463166007 2890439.2567717084 1.0 0.8586687039714693 0.9377688083840556 21.55555312469867 -10.162346806767783 5.114773388359177 1.000003355729949 0.8982187563121983 0.6882402959800064 0.03229248242157422 1.947173977110493e-06 3.1890107699562186e-07 0.031268685788385236 0.010422353882584756 6.88102591124575e-11 10.162346806767783 -0.10178459941775075 EGLELLK(ub)TAIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGLELLKTAIGK 12 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 9159840.0 2731200.0 2646540.0 3782100.0 True False 3580629.648978424 2251686.5481321192 3390764.5724649676 1.0 0.6288521206806573 0.9469743885498949 21.771781875133335 -10.118190034360325 7.258217478837101 1.0000000843616415 0.7879132546152761 0.37210455364347916 0.1298728720161034 1.7732112937878585e-07 2.1556638492217175e-08 0.1257489172661963 0.041916289203541304 7.61745619841758e-11 10.118190034360325 -0.2120868297463654 EGLELLK(ub)TAIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGLELLKTAIGK 12 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 20906370.0 5074970.0 3383300.0 12448100.0 True False 4913867.855248131 4734269.333676422 9187569.17500474 1.0 0.9634506814464102 1.8697224763975269 22.22842763029214 -6.897503846463945 0.9769358485919869 0.9596965246179484 1.9601650873410137 0.9852822608924747 0.05081612910586321 0.1132653810902369 0.1879734135500261 0.03918881516604945 0.10074135274301373 1.266182053126729e-07 6.897503846463945 1.0004685627230652 EGLELLK(ub)TAIGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGLELLKTAIGK 12 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 195681600.0 6299800.0 19029800.0 170352000.0 True False 9557257.177071845 15633783.509493953 136681852.53206602 1.0 1.6358023248552818 14.301368059862405 23.18816521004096 -6.917329049122947 0.8443116464623462 0.6927474138821976 16.223313231651712 0.9934060139596037 0.4974490784177907 0.09976868440594072 0.11394999481374062 0.4226488578079362 1.2354164504215974 1.2096812547906683e-07 6.917329049122947 15.530565817769514 up EGLELLK(ub)TAIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGLELLKTAIGK 12 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 11306800.0 2731200.0 2508300.0 6067300.0 True False 3740998.447904764 2397475.012161113 4634328.699965868 1.0 0.6408650111854166 1.2387946064402766 21.834991936656227 -6.744086400318219 1.6719853676028729 0.7873275016186 1.2394481412419538 0.6230100087300905 0.15088694369511796 0.31048694665192345 1.705801526381004 0.07135208368161683 0.17429544867043492 1.8026590768235337e-07 6.744086400318219 0.4521206396233538 EGLELLK(ub)TAIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGLELLKTAIGK 12 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 18903470.0 5074970.0 3217800.0 10610700.0 True False 4220062.41429117 3200465.0727167064 12829348.311666328 1.0 0.7583928289492556 3.040084968463963 22.008832905726415 -6.880719289201189 1.075736063082236 0.8487683256169337 3.2040624526224573 0.9742628524191606 0.16418474351408238 0.12699682438288368 0.2684284755698777 0.1174901727616935 0.28465801292772236 1.3160752163711834e-07 6.880719289201189 2.3552941270055237 up EGLELLK(ub)TAIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGLELLKTAIGK 12 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 218265500.0 6299800.0 10724700.0 201241000.0 True False 8155215.287623279 10127861.01723102 164617202.90703148 1.0 1.2418876338680496 20.185512840704764 22.95929153213341 -6.909685894431288 0.8978786728018378 0.40762537927031806 22.61721965344759 0.9908023150433299 0.8619582203236216 0.10462591468585841 0.13989946289965288 0.7046025463808766 1.9407963835510917 1.2311588904591898e-07 6.909685894431288 22.209594274177274 up EGLELPEDEEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGLELPEDEEEK 12 0 P08238;Q58FF7;P07900;P07900-2;Q58FG0;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA5P;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 4 0 134161800.0 1712800.0 82891000.0 49558000.0 False True 2245497.3867787956 70523985.90658736 44430213.55390369 1.0 31.406843900965402 19.786357274563382 21.098603612491107 -9.662733570873955 8.717567900534263 0.9999507221430985 25.59660058776552 0.8566032145263833 4.744043799672149 0.0 0.0 4.593400657413636 1.5311335524712115 2.1740344872484983e-10 9.662733570873955 24.59664986562242 EGLELPEDEEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGLELPEDEEEK 12 0 P08238;Q58FF7;P07900;P07900-2;Q58FG0;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA5P;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 4 0 119548400.0 25481000.0 9249400.0 84818000.0 False True 24672119.60259422 12942733.65498378 62601621.314542234 1.0 0.5245894500942221 2.5373426492290436 24.556378328321095 -6.844422538979781 1.2616439681117266 0.7470403761450197 2.6095766893522043 0.931797899957576 0.22432708150912758 0.16369984345860375 0.504226651204099 0.1393075533592519 0.32143238236623745 1.43079515553158e-07 6.844422538979781 1.8625363132071846 up EGLELPEDEEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGLELPEDEEEK 12 0 P08238;Q58FF7;P07900;P07900-2;Q58FG0;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA5P;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 4 0 154676800.0 1712800.0 47624000.0 105340000.0 False True 2346068.446679585 45519814.20849214 80460861.54539981 1.0 19.402594273375442 34.29604181381703 21.161813674014 -7.888455417878099 0.40851252272199845 8.602314326606794e-20 39.24395511358413 0.9960776804926891 0.8528859747613173 0.1284751612833305 0.09811981117098945 1.7464056909031638 3.6204879476798677 1.292839409299001e-08 7.888455417878099 39.24395511358413 EGLELPEDEEEK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGLELPEDEEEKK 13 1 P08238;Q58FF7;P07900;P07900-2;Q58FG0;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA5P;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 4 1 13984900.0 4773500.0 4872700.0 4338700.0 True False 6258104.7266397495 4145712.1536358325 3889772.9437491754 1.0 0.6624549020389832 0.6215576622089808 22.577294370974215 -13.999999999999998 0.29772996382058614 4.0391530757240055 0.6112562752735796 0.9996447609302254 0.0031962734477872295 16.44208224343203 0.17322540707655557 30.74329011268145 0.014925804150954134 1.0000000000000041e-14 13.999999999999998 -3.427896800450426 EGLELPEDEEEK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGLELPEDEEEKK 13 1 P08238;Q58FF7;P07900;P07900-2;Q58FG0;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA5P;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 4 1 12968000.0 4505300.0 3960900.0 4501800.0 True False 4362281.717576535 5542508.025820633 3322643.52889488 1.0 1.2705525192214713 0.7616755963988437 22.05665151202786 -6.762250259171828 1.6038443819150585 1.1567099374184742 0.759596341420324 0.7001531296112059 0.11383531597064947 0.27914922700285183 1.4156855229111802 0.05598604289783147 0.13425441521298656 1.7288198517231585e-07 6.762250259171828 -0.3971135959981502 EGLELPEDEEEK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGLELPEDEEEKK 13 1 P08238;Q58FF7;P07900;P07900-2;Q58FG0;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA5P;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 4 1 14340200.0 4773500.0 4532000.0 5034700.0 True False 6538391.948987028 4331761.254680123 3845607.552901323 1.0 0.6625117136563263 0.5881580032070594 22.640504432497107 -13.9999999999958 0.21257264553284416 2.9727499988278407 0.5454405430389605 0.9994916110666555 0.004040692554528791 12.808216382709093 0.14611761792893546 10.566379376361438 0.043263126423957715 1.0000000000096692e-14 13.9999999999958 -2.42730945578888 EGLELPEDEEEK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGLELPEDEEEKK 13 1 P08238;Q58FF7;P07900;P07900-2;Q58FG0;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA5P;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 4 1 14045700.0 7446600.0 3953500.0 2645600.0 True False 9639770.49443085 3733484.2495941888 2164127.9461483615 1.0 0.38730011795935615 0.22449994503485696 23.20056736821842 -13.999999999999972 0.18603391200363048 4.2407018125704345 0.10292752603403058 0.9994920870996854 0.007524710729690351 12.288810953206271 0.1367693498475234 14.417963420447846 0.11559488649780444 1.0000000000000655e-14 13.999999999999972 -4.137774286536404 EGLELPEDEEEK(ub)KKQEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGLELPEDEEEKKKQEEK 18 3 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 1 6127800.0 2312800.0 2204200.0 1610800.0 True False 2993965.1921037342 2081534.332352478 1317650.928203728 1.0 0.6952433307649348 0.4401022869868002 21.51362601801802 -7.241453519232883 0.18786939833594613 1.1966236355181925 2.2716221485578138e-13 0.9999882695063455 0.0007838754966393105 0.09796699753623067 0.009830140701808564 0.016926633858169837 0.041214056731893815 5.735172444729622e-08 7.241453519232883 -1.1966236355179654 down EGLELPEDEEEKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGLELPEDEEEKK 13 1 P08238;Q58FF7;P07900;P07900-2;Q58FG0;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA5P;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 4 0 4678250.0 3733100.0 945150.0 0.0 False True 3614594.783895626 1322553.323892139 0.0 1.0 0.3658925558639683 0.0 21.785402491457226 -8.425283505326824 0.5202645334055405 1.0440214493209903 2.279139137065713e-19 0.9929477253925689 0.03469242505006073 0.19174977372869334 0.1814883174169766 0.07122033185070423 0.06841533412636597 3.755921395202804e-09 8.425283505326824 -1.0440214493209903 EGLELPEDEEEKK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGLELPEDEEEKKK 14 2 P08238;Q58FF7;P07900;P07900-2;Q58FG0 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA5P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 1 64469000.0 21227000.0 19940000.0 23302000.0 True False 32202910.90156893 16381551.208068902 18696349.486370597 1.0 0.508697839712086 0.5805794868519077 24.940687767254804 -10.627652995214746 6.55724211487145 1.0016473530796577 0.5446386632820621 0.9816539143466696 0.02934555956055884 0.0007088450344046792 4.0251052104131276e-05 0.028498840494226185 0.009471238621931851 2.356931739170226e-11 10.627652995214746 -0.45700868979759557 EGLELPEDEEEKKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGLELPEDEEEKKK 14 2 P08238;Q58FF7;P07900;P07900-2;Q58FG0 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA5P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 61843200.0 1077200.0 36703000.0 24063000.0 False True 1412219.6316196383 31227055.46717343 21573191.588594846 1.0 22.112038926523013 15.276088156240336 20.42953304660727 -9.925925983801259 10.557057008612224 1.0000000742735 18.694063559026887 0.8993252127889989 2.790765215663031 0.0 0.0 2.702147002185092 0.9007156002864888 1.1859708542917697e-10 9.925925983801259 17.694063484753386 EGLELPEDEEEKKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGLELPEDEEEKKK 14 2 P08238;Q58FF7;P07900;P07900-2;Q58FG0 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA5P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 65583500.0 17923000.0 6458500.0 41202000.0 False True 17354044.17555421 9037412.730632558 30409960.166494936 1.0 0.5207669543312053 1.7523269999123292 24.04876857094177 -6.80116606022287 1.4511670346313195 0.7359911072859174 1.7698245818321428 0.8355929473215514 0.20552775688250413 0.21906645709256348 0.9106554341290262 0.11141528080019052 0.25892667453120244 1.5806435365248408e-07 6.80116606022287 1.0338334745462254 EGLELPEDEEEKKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGLELPEDEEEKKK 14 2 P08238;Q58FF7;P07900;P07900-2;Q58FG0 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA5P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 53244200.0 1077200.0 28017000.0 24150000.0 False True 1475469.9502354313 26779116.300170563 18446267.384862415 1.0 18.149550450619202 12.501960735912691 20.49274310813016 -9.587928495992264 8.297828401306385 0.9999977734623533 15.325755593266054 0.8956073085877203 2.305618846270977 0.0 0.0 2.2324058485770264 0.7441352828590085 2.58268537944375e-10 9.587928495992264 14.325757819803702 EGLELPEDEEEKKK(ub)MEESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGLELPEDEEEKKKMEESK 19 3 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 23611500.0 2402700.0 6633800.0 14575000.0 True False 3645071.56089884 5449946.559884024 11694244.861550571 1.0 1.4951548875874796 3.208234644004323 21.79751570748145 -6.948209721475635 0.5781635496854545 0.9793788754446133 3.808475539733012 0.999053203770385 0.029111861945709593 0.08421268021985354 0.038999558164776606 0.0305625656764373 0.14303242450744677 1.1266532621907515e-07 6.948209721475635 2.829096664288399 EGLELPEDEEEKKK(ub)MEESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGLELPEDEEEKKKMEESK 19 3 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 20130000.0 2402700.0 5516300.0 12211000.0 True False 3110342.5142976674 5209313.055782586 9988723.295440594 1.0 1.674835820118312 3.211454445780259 21.568642029573898 -6.957431613782203 0.47024316641052966 0.9595093924166065 3.989799604654379 0.9996627325107219 0.01699465407888931 0.08063181061527676 0.024621300395414127 0.021255960917146363 0.1268232153205179 1.102981901315489e-07 6.957431613782203 3.0302902122377726 EGLIDTAVK(ub)TAETGYIQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGLIDTAVKTAETGYIQR 18 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 69460600.0 5560700.0 7225900.0 56674000.0 True False 8435988.441624084 5936381.68878562 45472359.05890336 1.0 0.7036972288267807 5.390282285658168 23.00812568778164 -6.8918260960539035 1.0114937936117416 0.7590977707694536 5.808131328380388 0.9820424050740559 0.28715534106849433 0.11767495572718649 0.21328176521006334 0.21577218373891816 0.5415958648686213 1.2828441673595838e-07 6.8918260960539035 5.049033557610935 up EGLIDTAVK(ub)TAETGYIQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGLIDTAVKTAETGYIQR 18 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 99876700.0 5560700.0 7713000.0 86603000.0 True False 7198435.767784178 7283764.7697280925 70842142.62181984 1.0 1.0118538255666314 9.841324547044817 22.77925200987409 -6.9071901719809725 0.9146534849658274 0.7017399358018398 10.916389739415859 0.9898174076968683 0.4202902483721455 0.10630560592284634 0.14906182274075924 0.33938662335724384 0.9195914822009187 1.238254252150054e-07 6.9071901719809725 10.21464980361402 up EGLK(ub)ECYVFKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGLKECYVFKPK 12 2 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 1 10518200.0 3339200.0 2893700.0 4285300.0 True False 4377723.536858798 2461971.2395542525 3841898.2635002118 1.0 0.5623861851543099 0.8776018474334577 22.061749417265432 -10.004075241812787 5.4992697716679855 1.0000009339172446 0.7199940162935743 0.5126947520523559 0.12868625525398575 1.473430527915389e-06 2.670621069045139e-07 0.12460034675086447 0.04153331029021565 9.906602974574705e-11 10.004075241812787 -0.28000691762367036 EGLLDQQQGDVK(ub)TGAMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGLLDQQQGDVKTGAMK 17 1 Q14146 Q14146 URB2 Unhealthy ribosome biogenesis protein 2 homolog 1 32748400.0 1729200.0 2527200.0 28492000.0 True False 2238483.4876278876 2386559.098412656 23306748.35260778 1.0 1.0661499678702941 10.4118473428213 21.094090245436874 -6.908449902841117 0.9062017592229344 0.6962604273364371 11.580513197333728 0.9903239020847531 0.43490857114577786 0.10545272528604992 0.14438424070738723 0.3533585117314096 0.9652940229539352 1.2346677295476765e-07 6.908449902841117 10.88425276999729 up EGLLLWCQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGLLLWCQR 9 0 A0A494C1A0;P35609-2;P35609;A0A494C166;A0A494C033;O43707;P12814-2;P12814;P12814-3;P12814-4;H9KV75;Q08043;G3V2W4;G3V2N5;A0A087WSZ2;G3V2X9 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1;ACTN3 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-3 0 20632600.0 5440600.0 7287100.0 7904900.0 False True 7132679.286845342 6199893.084893318 7086976.777155103 1.0 0.8692235884385909 0.9935925186241688 22.76601267513283 -10.54587685791417 7.009384900176991 1.000044993443477 0.931408053532139 0.2885426701502901 0.05077340313508168 3.5723335912567215e-05 2.3143980454532645e-06 0.049193359164034216 0.016387045397703887 2.845267754900761e-11 10.54587685791417 -0.06863693991133801 EGLLLWCQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGLLLWCQR 9 0 A0A494C1A0;P35609-2;P35609;A0A494C166;A0A494C033;O43707;P12814-2;P12814;P12814-3;P12814-4;H9KV75;Q08043;G3V2W4;G3V2N5;A0A087WSZ2;G3V2X9 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1;ACTN3 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-3 0 17770400.0 5440600.0 5061800.0 7268000.0 False True 7452136.846686674 4838152.938865811 5551448.089158591 1.0 0.6492302863462474 0.7449471478273837 22.829222736655723 -10.089549085987048 7.243406949515206 1.000000077010328 0.6970887170868163 0.9303302258032831 0.03907624506824038 4.861455241153349e-08 6.071143699637458e-09 0.03783542117979867 0.01261180386513454 8.136748902519247e-11 10.089549085987048 -0.3029113599235116 EGLNGGGGGGSHFDSPFEFGFTFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGLNGGGGGGSHFDSPFEFGFTFR 24 0 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;O75190-4;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 0 61662000.0 14610000.0 28064000.0 18988000.0 False True 22164438.134070843 23055759.93496721 15235013.477263963 1.0 1.0402140489871583 0.6873629453229824 24.401743455026743 -6.878558436252017 1.08784534489905 1.0244771801518138 0.6630414288221896 0.9725022507590152 0.02615281654783731 0.1289128958118771 0.2800885238467292 0.018543124301340787 0.04468096424724497 1.3226397289845314e-07 6.878558436252017 -0.36143575132962413 EGLNGGGGGGSHFDSPFEFGFTFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGLNGGGGGGSHFDSPFEFGFTFR 24 0 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;O75190-4;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 0 38523000.0 14610000.0 12695000.0 11218000.0 False True 18912933.00615511 11988512.09019812 9176439.106400177 1.0 0.6338790544172352 0.4851938672554783 24.172869777119192 -13.999999999844945 0.12403621632435927 2.7410998791543033 0.2602937262350534 0.9996733889022055 0.003909544491500991 11.950093754058548 0.10888856879269045 5.103374296022444 0.1996761822527154 1.0000000003570265e-14 13.999999999844945 -2.48080615291925 EGLPVNNIFQQISPVVGDK(ub)QPTILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGLPVNNIFQQISPVVGDKQPTILK 25 1 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;Q9Y2X0-4;Q9Y2X0-5;U3KQ43;B9TWZ6;K7EKS6;U3KQB4 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 13770200.0 3596500.0 5451500.0 4722200.0 True False 2990649.1019647825 5422131.687461968 5709590.187014124 1.0 1.813028376983365 1.9091474768012953 21.512027215805162 -11.09648993440308 0.3832549345979689 1.4423201625645055e-14 1.9191297212464764 0.999502686472643 0.00909444371438028 3.0024656601710555 0.19001372927394275 2.6354026423004924 0.025742402305035477 8.007741877496314e-12 11.09648993440308 1.919129721246462 EGLQNMEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGLQNMEAR 9 0 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 11473500.0 2927100.0 1064700.0 7481700.0 False True 2834180.8127135322 1489840.2623371524 5522018.323811111 1.0 0.5256687419708883 1.9483648675626168 21.434500370376146 -6.816826151953575 1.3856247177243108 0.7434914684542253 1.9773409535690252 0.8769106573366684 0.20750921834477415 0.19763861085512283 0.7464651133903424 0.11771136865527701 0.2715523560567406 1.5246629541163538e-07 6.816826151953575 1.2338494851147999 EGLVMVEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGLVMVEVR 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 28784900.0 8974400.0 10240000.0 9570500.0 False True 11765525.308213219 8712231.915207379 8580236.466718486 1.0 0.7404881369066953 0.72926930519021 23.48806239978738 EGLVMVEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGLVMVEVR 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 81130000.0 16512000.0 34929000.0 29689000.0 False True 21375109.500180274 32985170.44494131 24285906.63486494 1.0 1.5431579634557249 1.136176946118574 24.34942847485159 -10.37651185260534 6.060038819566521 0.9999434218758624 1.3396674547870768 0.48152918743097617 0.1661493045791362 0.00012703952101272373 1.307058456970662e-05 0.16090007165240128 0.0536244574682448 4.2023105872924485e-11 10.37651185260534 0.33972403291121445 EGMNIVEAMER ddPTM_RPMI8226_Bortezomib_1h_R1 3 EGMNIVEAMER 11 0 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 297263700.0 31428600.0 153918000.0 111917100.0 False True 41203198.95499531 130954034.36766493 100336992.07662915 1.0 3.1782492061041436 2.4351748073304558 25.29625301466245 -10.165381436064793 5.54477805246316 0.9999574289624938 2.8067120067175058 0.8874163267362017 0.30335885298754733 0.00015964936340960917 2.403178613879267e-05 0.29373278200851966 0.09790864879534085 6.833112389115195e-11 10.165381436064793 1.806754577755012 EGMNIVEAMER ddPTM_RPMI8226_Bortezomib_2h_R1 4 EGMNIVEAMER 11 0 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 302182520.0 94186800.0 35776820.0 172218900.0 False True 91196891.58924781 50062690.79965161 127109603.63374549 1.0 0.5489517233233643 1.3937931591599535 26.442481315737492 -6.761676629287808 1.606213808849596 0.7385534907435518 1.3971331024767728 0.6977649801862931 0.18975977516128448 0.28010402819630004 1.424641695795754 0.09319879410075653 0.22359725104480155 1.731104840358743e-07 6.761676629287808 0.658579611733221 EGMNIVEAMER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGMNIVEAMER 11 0 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 336433700.0 2658300.0 331240000.0 2535400.0 False True 4032835.4477618462 272127634.01006776 2034277.0786947012 1.0 67.47799099045658 0.5044284858742971 21.943363109820954 -13.995802596704902 3.235282808199981e-14 9.540433666870097 51.84374501736005 0.0 32.38372841182838 0.0 0.28652118457185677 1253810410.041241 1253810398.6386812 1.0097117340225366e-14 13.995802596704902 42.30331135048995 EGMNIVEAMER ddPTM_RPMI8226_Carfilzomib_1h_R1 3 EGMNIVEAMER 11 0 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 292438000.0 31428600.0 139559500.0 121449900.0 False True 43048602.74597963 133393299.8284489 92765934.959205 1.0 3.098667350844661 2.154911635729421 25.359463076185342 -10.346686382339618 7.604454557962645 0.9999824933333941 2.6267894932870397 0.7984564260689078 0.38528665731129735 0.00011436572247712947 9.824947146110578e-06 0.37305618008075675 0.12435073394021494 4.501047723293817e-11 10.346686382339618 1.6268069999536456 EGMNIVEAMER ddPTM_RPMI8226_Carfilzomib_2h_R1 2 EGMNIVEAMER 11 0 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 107241700.0 72540100.0 16023700.0 18677900.0 False True 60320307.22130826 15937377.147644572 22583362.533147894 1.0 0.2642124664447111 0.3743907080959011 25.84614044072145 -10.112490185924067 5.403546949112476 1.0000108956578062 0.3193015872988152 0.9807295119775367 0.044980078801481624 5.9042195098689725e-06 9.697274276797555e-07 0.04355247052945224 0.01451725800894831 7.718089565298952e-11 10.112490185924067 -0.680709308358991 EGMNIVEAMER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGMNIVEAMER 11 0 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 22773700.0 2658300.0 13548000.0 6567400.0 False True 3441221.7529269117 12794041.890350847 5372200.587214522 1.0 3.717877779735917 1.5611317645092844 21.714489431913403 -6.5883173251287825 2.235113785746327 2.8414110474013694 1.5672209104859067 0.0 1.17824268314503 0.6744769263546854 6.349745076951415 0.4404811296820828 1.3139621140061113 2.580374104593937e-07 6.5883173251287825 -1.2741901369154627 EGNDLYHEMIESGVINLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 EGNDLYHEMIESGVINLK 18 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 40331500.0 5530000.0 22921200.0 11880300.0 False True 7249883.552596178 19501446.306137804 10651040.519884598 1.0 2.6898978672773786 1.4691326340090618 22.78952639211503 -10.42010984066899 5.649653582120659 0.999428455232382 2.079515250643223 0.5104361001335082 0.4983753195395187 0.0035895168209211553 0.00036843487558451174 0.4827783521257221 0.16084994272811162 3.800932519326624e-11 10.42010984066899 1.0800867954108408 EGNDLYHEMIESGVINLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGNDLYHEMIESGVINLK 18 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 72382000.0 24557000.0 14298000.0 33527000.0 False True 23777451.476822194 20007265.963084985 24745272.911559537 1.0 0.8414386202233526 1.0407033291890326 24.503090756133453 -6.694711821883458 1.8496759690946978 0.9010341699442047 1.040056336596986 0.39255447280059497 0.06699759675544631 0.406623840517636 2.700767301100029 0.02893785353428827 0.07491162664237033 2.0197061044843204e-07 6.694711821883458 0.13902216665278122 EGNDLYHEMIESGVINLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EGNDLYHEMIESGVINLK 18 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 55591900.0 5530000.0 23632200.0 26429700.0 False True 7574590.442630838 22588051.262765124 20187549.196757685 1.0 2.982082190957344 2.665167093806073 22.85273645363792 -10.216248759330831 6.053770350713222 0.9999671689005063 2.8236246423817164 0.9778512604138782 0.12938004663422387 5.733059148740528e-05 7.422304330287973e-06 0.1252739216853777 0.04175723049548649 6.077867676608404e-11 10.216248759330831 1.82365747348121 EGNDLYHEMIESGVINLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGNDLYHEMIESGVINLK 18 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 37330200.0 24557000.0 6057200.0 6716000.0 False True 20420233.559557643 6024568.661339939 8120284.548724497 1.0 0.2950293709309781 0.3976587498395099 24.28349603156773 -10.599383909799396 6.261825754474844 1.0020265674389472 0.346344060385244 0.9818469319121548 0.04189826849077617 0.0011880436257608287 7.600800241725767e-05 0.040658763966972836 0.013522608008308585 2.5154523225709955e-11 10.599383909799396 -0.6556825070537032 EGNDLYHEMIESGVINLK(ub)DATSK ddPTM_RPMI8226_Bortezomib_2h_R1 2 EGNDLYHEMIESGVINLKDATSK 23 1 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 1 85104600.0 27667900.0 27306000.0 30130700.0 True False 26789597.659142785 38209428.198908836 22238565.76837554 1.0 1.426278538597935 0.8301194385719315 24.67516957836987 -6.714741683675459 1.7781243480373263 1.2607894322940054 0.8313061547835249 0.48761515580791304 0.17950511911760642 0.36565229400801946 2.2563575352376644 0.08024703467274191 0.202715169856791 1.9286717370138565e-07 6.714741683675459 -0.42948327751048054 EGNDLYHEMIESGVINLK(ub)DATSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGNDLYHEMIESGVINLKDATSK 23 1 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 1 136695100.0 37158100.0 42184000.0 57353000.0 True False 56371554.32098684 34655935.61490365 46017154.41128712 1.0 0.6147770100070032 0.8163187083552736 25.748464011365392 -10.117022146969537 4.8806850746130515 1.0000139467270883 0.7155478591795744 0.7264766805165483 0.08227905381326547 1.2487207056211672e-05 2.259083429042182e-06 0.07967025504275735 0.026555450429270426 7.637968325497406e-11 10.117022146969537 -0.2844660875475139 EGNDLYHEMIESGVINLK(ub)DATSK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 EGNDLYHEMIESGVINLKDATSK 23 1 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 1 74733400.0 27667900.0 25484700.0 21580800.0 True False 23007084.745794903 25347408.862783104 26093245.50165479 1.0 1.1017218888375657 1.1341395830875076 24.455574853804148 -13.999999936284233 0.16001194825241374 0.49902136006489234 1.1660035774864248 0.9995363259576064 0.0012305309592393488 12.009754732579134 0.1264109206034676 1.8673093394756783 0.029041548643826 1.0000001467109858e-14 13.999999936284233 0.6669822174215325 EGNDLYHEMIESGVINLK(ub)DATSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGNDLYHEMIESGVINLKDATSK 23 1 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 1 116407000.0 37158100.0 31885900.0 47363000.0 True False 48101892.94565449 30111421.63504121 38743419.98541911 1.0 0.6259924462652872 0.8054448091926739 25.519590333457842 -10.060355061715363 4.956733382332923 1.0000062543033785 0.7157186277269262 0.7699079446882778 0.07326112039191933 5.063555145564641e-06 9.59868766605281e-07 0.07093633459709361 0.023644924932517065 8.702518161249303e-11 10.060355061715363 -0.28428762657645235 EGNGTVMGAELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGNGTVMGAELR 12 0 P05976-2;P05976;P08590 P05976-2 MYL1;MYL3 Myosin light chain 1/3, skeletal muscle isoform;Myosin light chain 3 0 43719400.0 8889400.0 15271000.0 19559000.0 False True 11654089.48507205 12992626.325891769 17535222.303176098 1.0 1.1148555485638132 1.5046411240995965 23.474332957680083 -6.948651662337191 0.5734648525191833 0.995217499802361 1.643343049702856 0.9990911072040244 0.006511027510238558 0.08403191815743276 0.03823971350723928 0.006871087522740399 0.03250487531013552 1.1255073557155085e-07 6.948651662337191 0.6481255499004951 EGNGTVMGAELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGNGTVMGAELR 12 0 P05976-2;P05976;P08590 P05976-2 MYL1;MYL3 Myosin light chain 1/3, skeletal muscle isoform;Myosin light chain 3 0 27954600.0 7018700.0 2366900.0 18569000.0 False True 6795895.210342142 3312015.51322044 13705221.841940789 1.0 0.4873552947344071 2.0166911669096783 22.696232176306978 -6.816333931783799 1.3878908182023144 0.7226274900945915 2.047462210924826 0.8756869536612494 0.22408317168673678 0.19829285766935875 0.7515328750511502 0.1269139156937147 0.29280809769647487 1.5263919544455165e-07 6.816333931783799 1.3248347208302345 up EGNGTVMGAELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGNGTVMGAELR 12 0 P05976-2;P05976;P08590 P05976-2 MYL1;MYL3 Myosin light chain 1/3, skeletal muscle isoform;Myosin light chain 3 0 38477000.0 8889400.0 8384600.0 21203000.0 False True 12176051.407002268 8014140.647835618 16195288.08949227 1.0 0.6581887986467274 1.330093603266047 23.537543019202975 -6.7684106583619865 1.5803824746111317 0.8035416004035618 1.3336585178217952 0.724440169960485 0.14399986600125209 0.2690399100877415 1.3258617901148044 0.07182819656236042 0.17124220014527355 1.7044699212200976e-07 6.7684106583619865 0.5301169174182334 EGNGTVMGAELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGNGTVMGAELR 12 0 P05976-2;P05976;P08590 P05976-2 MYL1;MYL3 Myosin light chain 1/3, skeletal muscle isoform;Myosin light chain 3 0 15182400.0 7018700.0 4635900.0 3527800.0 False True 5836360.03113032 4610925.4865459 4265446.669295754 1.0 0.7900344498886077 0.7308402234516829 22.476637451741254 -13.999999999891948 0.17760209808608451 2.0815762089059477 0.6826365152294404 0.9995012245496763 0.0025792106139186847 12.174646096566448 0.1335715179777888 4.541611824657199 0.04511395012685076 1.0000000002487995e-14 13.999999999891948 -1.3989396936765073 EGNNPAENGDAK(ub)TDQAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGNNPAENGDAKTDQAQK 18 1 P05204 P05204 HMGN2 Non-histone chromosomal protein HMG-17 1 25853200.0 10483000.0 10692000.0 4678200.0 True False 13743314.51751641 9096795.277089564 4194144.740463139 1.0 0.6619069414074262 0.3051770906587004 23.7122266495402 -7.316864734264703 0.29855439129344297 1.078966345482766 1.0311589675679014e-13 0.999856156850174 0.0034024718418959707 0.10669469558064228 0.021552746433327805 0.014148403102447507 0.050246488375278876 4.820979288821839e-08 7.316864734264703 -1.078966345482663 down EGNNPAENGDAK(ub)TDQAQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGNNPAENGDAKTDQAQK 18 1 P05204 P05204 HMGN2 Non-histone chromosomal protein HMG-17 1 39970700.0 14797000.0 15378000.0 9795700.0 True False 22448130.805602115 12633675.751137584 7859575.601392175 1.0 0.5627941079167601 0.3501216056452573 24.420091984912585 -11.272089591885702 0.13032311655583584 2.084434485715996 1.075273464598828e-15 0.9997467898538218 0.004304963768054969 3.793616514617544 0.08084360769711138 1.4439790544675868 0.2447649595618441 5.344540939172864e-12 11.272089591885702 -2.0844344857159953 EGNNPAENGDAK(ub)TDQAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGNNPAENGDAKTDQAQK 18 1 P05204 P05204 HMGN2 Non-histone chromosomal protein HMG-17 1 28047800.0 10483000.0 11311000.0 6253800.0 True False 14358848.39242298 10811242.619524915 4776781.241053935 1.0 0.7529324305164959 0.3326716119918499 23.77543671106309 -6.963083572420326 0.3895457788195477 1.0259418690522621 0.044572763486322095 0.999868027459693 0.0031646564849980574 0.07861744568017527 0.017191461019108276 0.005427452770555186 0.035358423712511314 1.0887205678347211e-07 6.963083572420326 -0.98136910556594 down EGNNPAENGDAK(ub)TDQAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGNNPAENGDAKTDQAQK 18 1 P05204 P05204 HMGN2 Non-histone chromosomal protein HMG-17 1 34985600.0 14858000.0 16912000.0 3215600.0 True False 12355085.321004504 16820891.699230842 3887967.0927454596 1.0 1.361454920156169 0.3146855721130185 23.558601637789206 -6.813451223531628 1.399847831858909 1.1962011614947754 0.2948668932234763 0.8686854302353755 0.15730849330736588 0.20212595738748926 0.779938349801531 0.08834251962846096 0.20406630433436437 1.5365573574231472e-07 6.813451223531628 -0.901334268271299 down EGNNPAENGDAK(ub)TDQAQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGNNPAENGDAKTDQAQK 18 1 P05204 P05204 HMGN2 Non-histone chromosomal protein HMG-17 1 37843500.0 14797000.0 18208000.0 4838500.0 True False 19155008.192476228 17194708.79388166 3957942.647202465 1.0 0.8976612602356108 0.2066270401678596 24.191218307005034 -6.9333891405471855 0.7184256140272499 1.009302190832716 0.051686062127181034 0.9971634664517368 0.018766583446484887 0.09091579277722137 0.06933579329302836 0.017456002389668275 0.061403105307972224 1.1657645898037637e-07 6.9333891405471855 -0.9576161287055349 down EGNVPNIIIAGPPGTGK(ub)TTSILCLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGNVPNIIIAGPPGTGKTTSILCLAR 26 1 P35250;P35250-2 P35250 RFC2 Replication factor C subunit 2 1 7802300.0 1434300.0 2490200.0 3877800.0 True False 1388768.9315961276 3484549.846221447 2862087.8484936156 1.0 2.509092597727266 2.060881247684729 20.40537514778548 -10.552581763953393 5.664113303672684 0.9962444709580309 2.284986922705998 0.9163808845130349 0.1829815174213676 0.00868225535062015 0.0006858256486374266 0.17726106886935664 0.059057030803059636 2.8016781043881072e-11 10.552581763953393 1.2887424517479669 EGNYK(ub)LAYELYTEALGIDPNNIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGNYKLAYELYTEALGIDPNNIK 23 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EPP7 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 15475400.0 8833600.0 1613300.0 5028500.0 True False 8553182.203268183 2257499.1032483564 3711384.998233578 1.0 0.2639367488729239 0.4339186176596884 23.02802984250857 -10.516916448575385 9.352885917859648 1.000019742579002 0.3489276832850089 0.9513643334996238 0.0693948073420493 2.8568732417063045e-05 1.4756678340872595e-06 0.06719325863095131 0.022397077762419105 3.041470100384116e-11 10.516916448575385 -0.6510920592939932 EGNYK(ub)LAYELYTEALGIDPNNIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGNYKLAYELYTEALGIDPNNIK 23 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EPP7 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 80827000.0 21109000.0 18945000.0 40773000.0 True False 32023896.274613436 15564116.732039375 32714198.67855924 1.0 0.4860157114728617 1.021555853105015 24.932645512168563 -10.966716127423028 12.646649115538839 1.0934079132764758 0.7537857822889383 0.21986286571958114 0.2186333472961017 0.09496579384212103 0.00024993385859001054 0.03491338130322367 0.0705636094169487 1.079652196327907e-11 10.966716127423028 -0.33962213098753746 EGNYK(ub)LAYELYTEALGIDPNNIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGNYKLAYELYTEALGIDPNNIK 23 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EPP7 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 66756000.0 21109000.0 21453000.0 24194000.0 True False 27326016.620597467 20259121.6912974 19790940.251403626 1.0 0.7413858365301121 0.7242526609782509 24.703771834261012 -13.999999999999998 0.38571197858258893 4.978713061561674 0.7228955779619938 0.9998165618417507 0.0017084801667886455 24.77402657462266 0.2031250767440329 82.03811684936669 0.0045659335398978 1.0000000000000041e-14 13.999999999999998 -4.25581748359968 EGNYLAVGTSSAEVQLWDVQQQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGNYLAVGTSSAEVQLWDVQQQKR 24 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 8401400.0 2856200.0 2292700.0 3252500.0 True False 3744505.859480141 1950638.096874602 2915962.5001830533 1.0 0.5209333808187481 0.7787309219454348 21.83634391654928 -10.084506704485966 5.189097852042702 1.0000062185907213 0.6498321513814665 0.7109820072297603 0.10524540545293748 7.571730607085756e-06 1.3357514805455241e-06 0.10190523435581345 0.03396780854835917 8.231771289033618e-11 10.084506704485966 -0.3501740672092547 EGNYLAVGTSSAEVQLWDVQQQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGNYLAVGTSSAEVQLWDVQQQKR 24 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 105656000.0 14951000.0 22426000.0 68279000.0 True False 14476388.688763652 31380818.75004502 50394681.57390685 1.0 2.167724245647143 3.48116389089652 23.787198413690025 -6.969600105054214 0.26756735809748616 0.6637081069771648 5.024538006047349 0.9999790926513552 0.004634239537207078 0.07643269868209283 0.009493600825703467 0.026135331833175176 0.12257102363625845 1.0725064061803762e-07 6.969600105054214 4.360829899070184 EGNYLAVGTSSAEVQLWDVQQQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGNYLAVGTSSAEVQLWDVQQQKR 24 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 301207000.0 37437000.0 127360000.0 136410000.0 True False 56794666.01130801 104631612.93177803 109448503.70937307 1.0 1.8422788666623293 1.9270912463431251 25.759252106610795 -11.074898651281881 0.4100871401283821 6.06581795354159e-11 1.9323293931099166 0.9995779258654143 0.008597424025609753 2.954922255097349 0.20151693965062534 2.777942813569736 0.021071578356947 8.415915159334837e-12 11.074898651281881 1.9323293930492584 EGNYLAVGTSSAEVQLWDVQQQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGNYLAVGTSSAEVQLWDVQQQKR 24 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 13061800.0 2856200.0 2651900.0 7553700.0 True False 3912214.325902744 2534730.289339416 5769671.633334801 1.0 0.6479016940756502 1.4747841382650855 21.89955397807217 -6.791025749108435 1.4924487626782237 0.8034760404091642 1.4838022077237003 0.804571469435257 0.1497785929025691 0.23382304006995472 1.0289031655210352 0.07899228869199408 0.1847857682444288 1.6179841053091685e-07 6.791025749108435 0.6803261673145361 EGNYLAVGTSSAEVQLWDVQQQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGNYLAVGTSSAEVQLWDVQQQKR 24 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 81142000.0 14951000.0 24243000.0 41948000.0 True False 12432418.941603074 24112398.147141263 50719132.85436206 1.0 1.9394776077286966 4.079586852132107 23.5676036891243 -6.957422274905399 0.4703559499398862 0.943668905327901 5.163182308184728 0.9996623281639706 0.02368080708861505 0.08063510073193589 0.0246334107658456 0.02961032068040987 0.17663052854984318 1.1030056196063579e-07 6.957422274905399 4.219513402856827 EGNYLAVGTSSAEVQLWDVQQQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGNYLAVGTSSAEVQLWDVQQQKR 24 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 297977000.0 37437000.0 122210000.0 138330000.0 True False 48462934.4935954 115408906.06877613 113155359.38566029 1.0 2.3813850167085517 2.3348845992933898 25.530378428703244 -10.56727730165298 6.079086876016314 0.996820315703679 2.3581348080009708 0.9991215691470761 0.0189837159155961 0.0008183842666704667 5.825425966466808e-05 0.018387333805697872 0.006126967965853021 2.7084616980131708e-11 10.56727730165298 1.3613144922972917 EGPAGHSK(ub)GELAPELGEEPQPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGPAGHSKGELAPELGEEPQPR 22 1 Q9HCU8-2;Q9HCU8 Q9HCU8-2 POLD4 DNA polymerase delta subunit 4 1 9510700.0 1493300.0 1069700.0 6947700.0 True False 1445896.0088910933 1496836.7884118073 5127888.943467721 1.0 1.0352312885625725 3.5465129663097095 20.463532364454082 -6.90995557793723 0.8960302456486531 0.9221336340568257 3.8707527269557023 0.9909047460041543 0.11370091551763732 0.10444821410794905 0.13892484453924062 0.09306749977046173 0.25683172905396995 1.2303946160025522e-07 6.90995557793723 2.9486190928988765 up EGPAGHSK(ub)GELAPELGEEPQPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGPAGHSKGELAPELGEEPQPR 22 1 Q9HCU8-2;Q9HCU8 Q9HCU8-2 POLD4 DNA polymerase delta subunit 4 1 9810280.0 1493300.0 2662300.0 5654680.0 True False 1241745.1144067855 2647957.661474822 6837047.443713733 1.0 2.1324486247242627 5.505999068882966 20.243937639888358 -6.951608579202342 0.5408959817546317 0.9506232580022765 6.843854456708028 0.9993215471346419 0.04985174208231811 0.08284617938487097 0.03333839734864291 0.054764032082304424 0.2794179498943086 1.1178703076996664e-07 6.951608579202342 5.8932311987057515 EGPEEPGLAK(ub)QDSFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGPEEPGLAKQDSFR 15 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 11929400.0 2391400.0 3908300.0 5629700.0 True False 3135148.5583505407 3325196.8744340795 5047192.6478956295 1.0 1.0606185998993065 1.6098735208104622 21.580102375770203 -6.927854861458928 0.7641848109789543 0.9909498699960154 1.7167144283089628 0.9960999001864851 0.01713197903957811 0.09376644119444051 0.08324642768098689 0.015413521004579137 0.05029676008323427 1.1807151574583841e-07 6.927854861458928 0.7257645583129474 EGPEEPGLAK(ub)QDSFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGPEEPGLAKQDSFR 15 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 18119600.0 4935800.0 4607500.0 8576300.0 True False 7487969.455314654 3785255.6264381898 6881190.545874181 1.0 0.5055116275549936 0.9189661612455156 22.836143119262058 -10.068144545334864 7.335722110047648 1.000000041995178 0.7122388944002551 0.39241985836956716 0.16879210656368934 1.1586281729619204e-07 1.4607228384664473e-08 0.16343227877633204 0.05447741814103638 8.547821701522956e-11 10.068144545334864 -0.2877611475949229 EGPEEPGLAK(ub)QDSFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGPEEPGLAKQDSFR 15 1 J3KPS2;A0A494C1T9;Q6ZRV2 J3KPS2 FAM83H Protein FAM83H 1 8789500.0 2391400.0 2059400.0 4338700.0 True False 3275565.2051550406 1968408.8984748998 3313988.418331369 1.0 0.6009371742553146 1.0117302544049065 21.643312437293094 -10.961496994049257 11.37413447235792 1.0706505676511937 0.8063337143302474 0.22860160494373283 0.16770557270545558 0.09306321799245516 0.0003150314117969756 0.05029536101574901 0.054126740846200505 1.0927051902751283e-11 10.961496994049257 -0.26431685332094634 EGPGLAELLANVASSILSHIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGPGLAELLANVASSILSHIK 21 0 Q9UID3;Q9UID3-2 Q9UID3 VPS51 Vacuolar protein sorting-associated protein 51 homolog 0 263673000.0 77023000.0 114930000.0 71720000.0 False True 116849522.13556069 94419843.54781146 57544510.56400737 1.0 0.8080464671329347 0.4924668027075732 26.800076593227626 -6.963688892759064 0.3798860224612729 1.021705078636213 0.2676505667973173 0.9998835095804525 0.0022583186332963286 0.0784087785481291 0.016446562199503825 0.004107443494797802 0.026667637304344374 1.0872041644061243e-07 6.963688892759064 -0.7540545118388957 down EGPGPEDTVQDNLGAAGAEEEQEEHQK(ub)CQQPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGPGPEDTVQDNLGAAGAEEEQEEHQKCQQPR 32 1 P33241;P33241-3;E7EMG9;C9JU59;P33241-2;E9PBD8;C9JKF7 P33241;P33241-2 LSP1 Lymphocyte-specific protein 1 1 17111400.0 5734900.0 6785900.0 4590600.0 True False 7518509.436850606 5773470.171231027 4115608.748144597 1.0 0.7679009010660295 0.5473968986422614 22.84201524170401 -6.971746994125102 0.2123570739882794 1.1120310300147733 0.19709476481262939 0.9999929904920714 0.0004892185609115317 0.07573984859225531 0.0069644842032647565 0.006481171455879728 0.022726599083718855 1.0672176665543128e-07 6.971746994125102 -0.914936265202144 EGPIDLGACNQDDWISAVRPVIEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGPIDLGACNQDDWISAVRPVIEKR 25 2 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 141817000.0 67303000.0 36348000.0 38166000.0 True False 65166503.104799636 50861945.95231599 28169179.64454262 1.0 0.7804921781750465 0.43226471120049875 25.957627244884428 -6.964309833833047 0.3697065380881122 1.0268681939168938 0.17377301966219366 0.9998982026228815 0.0023584490240545594 0.0781959472942238 0.01569055721342237 0.00459195562486818 0.029579399603906483 1.085650823601394e-07 6.964309833833047 -0.8530951742547002 down EGPIDLGACNQDDWISAVRPVIEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGPIDLGACNQDDWISAVRPVIEKR 25 2 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 352880000.0 111890000.0 120970000.0 120020000.0 True False 169745310.25470155 99381958.35707612 96297994.39336534 1.0 0.5854769018829106 0.5673087182725162 27.33879647515507 EGPIDLGACNQDDWISAVRPVIEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGPIDLGACNQDDWISAVRPVIEKR 25 2 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 92561000.0 18366000.0 23489000.0 50706000.0 True False 25156406.522487853 22451178.312264208 38730287.12285031 1.0 0.8924636470711592 1.539579474048826 24.584422518763997 -6.864199884051459 1.1642558521552393 0.940861248838583 1.5735369680329756 0.9585483197906294 0.05764460148071555 0.14254202747860115 0.3647784220600386 0.0385439800384512 0.09044739480787102 1.3670994731938095e-07 6.864199884051459 0.6326757191943926 EGPIDLGACNQDDWISAVRPVIEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGPIDLGACNQDDWISAVRPVIEKR 25 2 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 141660000.0 67303000.0 40222000.0 34135000.0 True False 55965426.52844031 40005316.1025581 41272470.67759244 1.0 0.7148219639178188 0.7374637028205038 25.738032520318704 -10.705967371166633 6.736092188293528 1.00286347381594 0.7261428333691619 0.9948995090170909 0.009243451200150273 0.0004008665315118861 1.7497932370486578e-05 0.009025730235494588 0.0029833110466385804 1.9680341438671725e-11 10.705967371166633 -0.27672064044677824 EGPNFITK(ub)EGTVSDHIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGPNFITKEGTVSDHIER 18 1 Q93100-4;Q93100-2;Q93100-3;Q93100;I3L213 Q93100-4 PHKB Phosphorylase b kinase regulatory subunit beta 1 20212600.0 1885800.0 6580800.0 11746000.0 True False 2441205.274675382 6214572.6950118765 9608348.524137689 1.0 2.5456985364896267 3.935903557071969 21.219162182060877 -6.972383302992414 0.1929454675086778 0.09330274104986265 6.426394894469375 0.9999954952613316 0.002545087892032639 0.07553665155558362 0.006176883101682573 0.04786876322578532 0.15033224397930195 1.0656551718488835e-07 6.972383302992414 6.333092153419512 EGPYDVVVLPGGNLGAQNLSESAAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGPYDVVVLPGGNLGAQNLSESAAVK 26 0 Q99497;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 18860200.0 1381900.0 12558600.0 4919700.0 False True 1811684.2823386362 10684905.833039397 4410656.637094714 1.0 5.897774759764791 2.434561407907762 20.788900131777794 -6.55597009806495 2.3620083909196894 4.381919806245245 2.439238337758974 0.0 2.1405966047433287 0.77474621308063 8.095206726425518 0.772938509576172 2.4127423135019854 2.7799046624708413e-07 6.55597009806495 -1.9426814684862705 EGPYDVVVLPGGNLGAQNLSESAAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGPYDVVVLPGGNLGAQNLSESAAVK 26 0 Q99497;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 54338200.0 20133300.0 6581900.0 27623000.0 False True 19494179.411911253 9210086.994155055 20387707.627762966 1.0 0.4724531768968714 1.0458356413456291 24.216540091412714 -6.664843648539792 1.9561233154784072 0.6617859825707265 1.0434526014491712 0.2563087978460845 0.22436016422012076 0.4730050778183343 3.484318608525321 0.09251316374498848 0.24880329973951673 2.163497269690135e-07 6.664843648539792 0.38166661887844466 EGPYDVVVLPGGNLGAQNLSESAAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGPYDVVVLPGGNLGAQNLSESAAVK 26 0 Q99497;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 15782720.0 1381900.0 5079320.0 9321500.0 False True 1892825.774443319 4854898.847334924 7119953.682318631 1.0 2.5648947266489714 3.761547300576363 20.852110193300685 -7.675102233698207 0.19607187042767163 1.9574235542125396e-17 5.509450515982161 0.9999205161106031 0.010080906690809199 0.13693007507259825 0.024545243988005606 0.21783998989365627 0.37733925161494064 2.1129915792884425e-08 7.675102233698207 5.509450515982161 EGPYDVVVLPGGNLGAQNLSESAAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGPYDVVVLPGGNLGAQNLSESAAVK 26 0 Q99497;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 26733800.0 20133300.0 2748400.0 3852100.0 False True 16741731.006419443 2733593.823685313 4657556.299901967 1.0 0.16328023802539565 0.27820040222340664 23.99694536684699 -10.756843181139644 7.087039132793421 1.0147373811273173 0.22074032012440115 0.9839504608082004 0.04691596057366442 0.010522188958902697 0.00036101658404500157 0.04375268530073409 0.015142061164427166 1.750478652704115e-11 10.756843181139644 -0.7939970610029161 EGPYSISVLYGDEEVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGPYSISVLYGDEEVPR 17 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 5578900.0 1754200.0 2108100.0 1716600.0 False True 2299773.1876969645 1793579.6973094395 1538982.6987899223 1.0 0.7798941682181987 0.6691889039419092 21.13306015348506 -13.999999997425912 0.08893290820098382 2.1323816745857456 0.38701688171266285 0.9998473859610234 0.0016985346648177432 12.173418694283955 0.086384926033665 2.615783986961441 0.25377550736665827 1.0000000059270578e-14 13.999999997425912 -1.7453647928730827 EGPYSISVLYGDEEVPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGPYSISVLYGDEEVPR 17 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 8770700.0 2560200.0 1485900.0 4724600.0 False True 2478927.8523826245 2079227.6188661323 3487085.525038157 1.0 0.8387608444786645 1.406691010263385 21.241284852638895 -6.830860594593962 1.3241578243107373 0.9138966794464121 1.4222334751945822 0.907568058599856 0.07265175758990236 0.179751281076639 0.6161113673040733 0.04307621741383675 0.09912355135914948 1.4761803004963568e-07 6.830860594593962 0.5083367957481701 EGPYSISVLYGDEEVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGPYSISVLYGDEEVPR 17 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 8316200.0 1754200.0 2564700.0 3997300.0 False True 2402775.145472516 2451383.073671255 3053220.066977663 1.0 1.0202299113549305 1.2707056974227333 21.196270215007953 -6.922945576688878 0.802562421198166 0.9950380521377885 1.3139689701866466 0.994961151035841 0.008739721209167783 0.09646933676323734 0.09685455655647317 0.007650131383485213 0.023603470554814886 1.1941377376290353e-07 6.922945576688878 0.3189309180488581 EGPYSISVLYGDEEVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGPYSISVLYGDEEVPR 17 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 6593800.0 2560200.0 2061300.0 1972300.0 False True 2128919.7360907043 2050195.3677639873 2384698.8111151448 1.0 0.9630214483936923 1.1201450062622478 21.02169012807317 -6.844663272918914 1.260475462307206 0.9803226032330148 1.1258114098085512 0.9321839484156691 0.017467032187151246 0.16342879745237193 0.5023428451463474 0.010856434480468132 0.025052698750841252 1.4300022706981987e-07 6.844663272918914 0.14548880657553642 EGQEDQGLTK(ub)DYGNSPLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGQEDQGLTKDYGNSPLHR 19 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;A0A087WUW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 1 23597200.0 8557500.0 8402000.0 6637700.0 True False 11218965.370947871 7148454.350739479 5950894.477314388 1.0 0.6371758994150026 0.5304316646457041 23.419436298890158 -13.999999999999998 0.17150943619730752 2.8370747880571527 0.4377683037239163 0.9995108791001319 0.004444845461469317 12.106560418694315 0.13117257078020061 7.400547505342207 0.08584563574685097 1.0000000000000041e-14 13.999999999999998 -2.3993064843332363 EGQEDQGLTK(ub)DYGNSPLHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGQEDQGLTKDYGNSPLHR 19 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;A0A087WUW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 1 129668000.0 24800000.0 28323000.0 76545000.0 True False 37623413.1228581 23268539.361390933 61415847.19913468 1.0 0.6184590240499508 1.6323837233635108 25.165127397497482 -6.804748650093099 1.436255259676377 0.7907321095130418 1.6481086686592024 0.8457278244701976 0.16423265233116513 0.2140513495062962 0.8711376696651921 0.08993302180956607 0.20859419751306263 1.5676580968643533e-07 6.804748650093099 0.8573765591461605 EGQEDQGLTK(ub)DYGNSPLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGQEDQGLTKDYGNSPLHR 19 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;A0A087WUW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 1 29260500.0 8557500.0 11280000.0 9423000.0 True False 11721439.007742012 10781612.302028213 7197481.472776757 1.0 0.9198198527422236 0.6140441858736644 23.48264636041305 -6.945972733966719 0.6014448113144039 1.0034334854814635 0.514739160380144 0.9988460504070674 0.005649047542483063 0.08514455988715514 0.04297547779021291 0.005789622944199237 0.025708715391993472 1.1324714602366351e-07 6.945972733966719 -0.4886943251013195 EGQEDQGLTK(ub)DYGNSPLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGQEDQGLTKDYGNSPLHR 19 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;A0A087WUW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 1 41594300.0 13144600.0 18891000.0 9558700.0 True False 10930317.304514453 18789230.43343011 11557379.975564742 1.0 1.7190013711376666 1.0573691187163705 23.381831946923537 -10.407802046410973 5.336986730220077 0.9997317829364485 1.3881852449270249 0.31458452459213126 0.2701102359667716 0.0008626218955421241 9.57169423460283e-05 0.26171094690995744 0.08717770379495197 3.910190836267082e-11 10.407802046410973 0.3884534619905764 EGQEDQGLTK(ub)DYGNSPLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGQEDQGLTKDYGNSPLHR 19 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;A0A087WUW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 1 127167000.0 24800000.0 24814000.0 77553000.0 True False 32104088.881084647 23433079.08674095 63439149.760978274 1.0 0.7299094882754154 1.9760457926702253 24.93625371958993 -6.849955472663092 1.2353114410862096 0.8558776720372723 2.0258177768433336 0.9402425308144626 0.13084462332618538 0.15750328054519705 0.46253612729831817 0.08288418188922043 0.19179282358619243 1.4126823766715206e-07 6.849955472663092 1.1699401048060614 EGQEEVLK(ub)EVVESEGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGQEEVLKEVVESEGER 17 1 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 10504900.0 4035100.0 3319000.0 3150800.0 True False 5290055.175963981 2823818.1373606683 2824785.440607765 1.0 0.5337974829054779 0.5339803360544378 22.33485133923899 -10.013353226245048 4.966397229564648 1.0000058665827936 0.5338889094760911 0.9999998838878862 7.464950453716038e-05 4.849328907795457e-09 9.634507897421027e-10 7.227997248479109e-05 2.4093021264271822e-05 9.697209399050139e-11 10.013353226245048 -0.4661169571067024 EGQEEVLK(ub)EVVESEGER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGQEEVLKEVVESEGER 17 1 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 8458700.0 4195400.0 4263300.0 0.0 True False 4062219.323445851 5965657.922815798 0.0 1.0 1.4685711055491018 0.0 21.95383670366668 -6.84354445571836 1.4210111723548386 1.250695902476312 7.821653818798618e-22 0.8856020313044364 0.2071599710461868 0.180852605449872 0.7334590592336743 0.11702068300329313 0.24922641751782484 1.4336909515307759e-07 6.84354445571836 -1.250695902476312 down EGQEEVLK(ub)EVVESEGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGQEEVLKEVVESEGER 17 1 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 9997600.0 4035100.0 2400400.0 3562100.0 True False 5526985.514477336 2294342.390938695 2720805.343752319 1.0 0.41511641109406117 0.49227654688536204 22.398061400761883 -10.60928901779939 6.514451267323333 1.001556561722368 0.45369647899015464 0.9852589093790998 0.03150049352875811 0.0007137756106066338 4.280934609156875e-05 0.03057041329402086 0.010166740569516221 2.458730803539344e-11 10.60928901779939 -0.5478600827322134 EGQEEVLK(ub)EVVESEGER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGQEEVLKEVVESEGER 17 1 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 12151500.0 4195400.0 5842200.0 2113900.0 True False 3488660.9877333585 5810726.909014095 2555906.716430721 1.0 1.6656037744697634 0.7326325846557353 21.734241979100958 -6.7151455650716665 1.7768194947440368 1.4070241498377685 0.7344676075640579 0.489551752549618 0.2802666923361015 0.364808569409266 2.248111296996482 0.1253774546980514 0.31655126514496223 1.9268789614296688e-07 6.7151455650716665 -0.6725565422737105 EGQENGHITTK(ub)SVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGQENGHITTKSVK 14 1 P11717 P11717 IGF2R Cation-independent mannose-6-phosphate receptor 1 15881900.0 4850300.0 6420500.0 4611100.0 True False 6358790.270372013 5462586.426912986 4133987.6047944813 1.0 0.8590606380533139 0.6501217101083329 22.60032089506347 -6.965451852765903 0.35021157104955636 1.020142343947128 0.4819873761685393 0.9999221566966442 0.0012681321405028597 0.07780798176306598 0.014321223824841176 0.0028664716654049406 0.01795636027907774 1.0827997510142681e-07 6.965451852765903 -0.5381549677785886 EGQNWLEK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGQNWLEKK 9 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 26585400.0 1317100.0 4440300.0 20828000.0 True False 1095227.007423275 4416379.222569463 25183038.50220876 1.0 4.032387069197477 22.993441844952798 20.062798497178733 -6.934967508359042 0.7048236526151608 0.7578251726462308 27.429037466660784 0.9974276664695192 0.49359568402315324 0.09013922007750025 0.06563695728225429 0.46381139521929754 1.6712786484753985 1.161535510599606e-07 6.934967508359042 26.671212294014552 EGQNWLEK(ub)K(ub)DVVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGQNWLEKKDVVGR 14 2 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 2 37089400.0 4281400.0 20466000.0 12342000.0 True False 6495196.812266324 16813682.398412157 9902598.290309241 1.0 2.588633244593781 1.5246032686196611 22.63094181105256 -10.51808787866795 5.305553280471086 0.9970683800134958 2.0566182566067264 0.5680014927212562 0.4343884186937585 0.015085527960964807 0.0013702421606541088 0.4212171750765543 0.14019825928218904 3.033277344151513e-11 10.51808787866795 1.0595498765932305 EGQNWLEK(ub)K(ub)DVVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGQNWLEKKDVVGR 14 2 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 2 16868000.0 1909700.0 3872300.0 11086000.0 True False 2615767.6977020088 3701208.9820162933 8467715.123336839 1.0 1.4149608871108321 3.2371816238788536 21.31880299232586 -6.942736675173925 0.6335914075774631 0.9801124308521638 3.77084439081278 0.9985008415819258 0.03762289798566862 0.08654001608307568 0.04908846216452059 0.037432577089954316 0.15504314190553486 1.1409413623674659e-07 6.942736675173925 2.790731959960616 up EGQNWLEK(ub)K(ub)DVVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGQNWLEKKDVVGR 14 2 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 2 17165900.0 2636600.0 3303300.0 11226000.0 True False 2192449.721184579 3285504.4672462847 13573304.696840577 1.0 1.4985540765199983 6.190930886892553 21.06411232746538 -6.927203787366349 0.7693947450068023 0.920756032908075 7.089074862832033 0.9959596023265826 0.14863787395448966 0.0941160812652701 0.08498444932949183 0.13322817347093738 0.4312918867564965 1.1824865581882399e-07 6.927203787366349 6.168318829923957 up EGQNYQQNCIK(ub)EVEQFTQVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGQNYQQNCIKEVEQFTQVAK 21 1 O96000-2;O96000;H3BPJ9 O96000-2 NDUFB10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 1 25337200.0 3999600.0 7381600.0 13956000.0 True False 5243514.332181491 6280294.053251432 12511966.995404975 1.0 1.197726115614259 2.386179612138019 22.322102634937 -6.935798059326475 0.6975645896578767 0.9852097378318933 2.670576164415742 0.9975600256184708 0.03023989405617831 0.08973698014268228 0.06373874633042548 0.028571654660592177 0.10432075537980476 1.1593162962113825e-07 6.935798059326475 1.6853664265838488 up EGQNYQQNCIK(ub)EVEQFTQVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGQNYQQNCIKEVEQFTQVAK 21 1 O96000-2;O96000;H3BPJ9 O96000-2 NDUFB10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 1 14908400.0 5247600.0 3317500.0 6343300.0 True False 5081017.810391015 4642195.050533955 4681799.4350790605 1.0 0.9136348707615944 0.9214294477583749 22.276686090518993 -10.27992224568356 5.453051687495721 1.000009764801296 0.9175321592599811 0.9933445342116813 0.0031821227338369824 3.778092177341666e-07 4.9888557154645206e-08 0.003081441851198749 0.0010270256961430859 5.249014280530193e-11 10.27992224568356 -0.08247760554131489 EGQNYQQNCIK(ub)EVEQFTQVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGQNYQQNCIKEVEQFTQVAK 21 1 O96000-2;O96000;H3BPJ9 O96000-2 NDUFB10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 1 377160000.0 17169000.0 49531000.0 310460000.0 True False 26046628.222030304 40691806.06253069 249097444.92054784 1.0 1.5622677037373096 9.563519807521981 24.63459328960601 -6.921081473752375 0.8166660071685268 0.8302444199396652 10.88644395680846 0.994476068964003 0.29068499005220516 0.09753971538207999 0.10234771518617733 0.25189947882045355 0.7625389191341202 1.199274297889186e-07 6.921081473752375 10.056199536868794 up EGQNYQQNCIK(ub)EVEQFTQVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGQNYQQNCIKEVEQFTQVAK 21 1 O96000-2;O96000;H3BPJ9 O96000-2 NDUFB10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 1 25872000.0 3999600.0 6675400.0 15197000.0 True False 5478360.205125907 6380458.755404165 11607781.592039512 1.0 1.1646657971548122 2.1188423465069937 22.38531269645989 -6.9365769647635664 0.6906789634560091 0.9883956444154082 2.3521519868483742 0.9976802379978982 0.02375530523523846 0.08936355957768348 0.06198570316857014 0.02256312309702036 0.0834375196156041 1.1572389304458884e-07 6.9365769647635664 1.363756342432966 up EGQNYQQNCIK(ub)EVEQFTQVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGQNYQQNCIKEVEQFTQVAK 21 1 O96000-2;O96000;H3BPJ9 O96000-2 NDUFB10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 1 372547000.0 17169000.0 32378000.0 323000000.0 True False 22225608.95158641 30576135.837450556 264217314.2598733 1.0 1.375716449616923 11.88796738192472 24.40571961169846 -6.914473776410576 0.8647137384866792 0.7187418016882499 13.384987365979375 0.992503172998486 0.4369395942870875 0.10153338965762532 0.12327003507008717 0.36583812118918896 1.0441036529202614 1.2176605154588804e-07 6.914473776410576 12.666245564291126 up EGRPSGEAFVELESEDEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGRPSGEAFVELESEDEVK 19 1 P31943;G8JLB6;E9PCY7;D6RBM0;D6RIU0;E7EN40;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;D6RDL0 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 20279500.0 6035200.0 3843300.0 10401000.0 False True 5843615.879501458 5377949.732544735 7676666.0766883595 1.0 0.9203119854968204 1.3136842384895575 22.478429917391725 -6.853990066117996 1.2158438265806255 0.9572867307347641 1.3306477570398754 0.9458892005270061 0.039498516722471504 0.15312661198099758 0.43362325858073114 0.025393416310607455 0.05892585882999417 1.3996193365513977e-07 6.853990066117996 0.37336102630511125 EGSGGGGGMDDIFSHIFGGGLFGFMGNQSR ddPTM_RPMI8226_Bortezomib_8h_R1 2 EGSGGGGGMDDIFSHIFGGGLFGFMGNQSR 30 0 O60884 O60884 DNAJA2 DnaJ homolog subfamily A member 2 0 2783220000.0 1479960000.0 668100000.0 635160000.0 False True 2245207519.568755 548872335.1108752 509620347.599483 1.0 0.24446396617106425 0.22698140067576808 31.064201650229496 EGSGGGGGMDDIFSHIFGGGLFGFMGNQSR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 EGSGGGGGMDDIFSHIFGGGLFGFMGNQSR 30 0 O60884 O60884 DNAJA2 DnaJ homolog subfamily A member 2 0 2401253000.0 1479960000.0 393930000.0 527363000.0 False True 1915837394.372987 372007449.2076995 431388345.2013296 1.0 0.19417485549677854 0.22516960284226722 30.835327972321945 -10.499002859596342 6.1438581183344345 1.0006603161118472 0.20967222916970354 0.9988478145319395 0.012653552617155258 0.00011453334101041642 9.339556489521015e-06 0.012260909415538309 0.004083916546383442 3.169546593209635e-11 10.499002859596342 -0.7909880869421437 EGSLLSK(ub)QEESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGSLLSKQEESK 12 1 O00273-2;O00273 O00273-2 DFFA DNA fragmentation factor subunit alpha 1 3319700.0 1232200.0 1062400.0 1025100.0 True False 1193084.4854721809 1486621.860342811 756595.5576591903 1.0 1.2460323459444353 0.6341508643118063 20.18626477703131 -6.797586084683215 1.4659080595540936 1.1361653008375139 0.6262142460973361 0.8249647136190105 0.1051749595634533 0.22422304987027714 0.9515073276198249 0.05645211194802859 0.13147527195955513 1.5937269451360627e-07 6.797586084683215 -0.5099510547401778 EGSLLSK(ub)QEESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGSLLSKQEESK 12 1 O00273-2;O00273 O00273-2 DFFA DNA fragmentation factor subunit alpha 1 7012700.0 1442200.0 2493300.0 3077200.0 True False 2187922.8389429846 2048351.134758186 2468990.0712153255 1.0 0.9362081232022663 1.1284630459857206 21.061130429101247 -6.817264861484143 1.3836141380927856 0.965518210834663 1.1324206680628204 0.8779850501074987 0.02792852317214016 0.19706199366391172 0.7420004020801774 0.01586475470789909 0.03659598404370849 1.5231235690483126e-07 6.817264861484143 0.16690245722815733 EGSLLSK(ub)QEESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGSLLSKQEESK 12 1 O00273-2;O00273 O00273-2 DFFA DNA fragmentation factor subunit alpha 1 4512500.0 1232200.0 2176300.0 1104000.0 True False 1024628.8957155582 2164575.8399382713 1334841.2956807388 1.0 2.1125461608484324 1.302755857522973 19.966670052465588 -10.03040205309976 4.382316652443847 0.9999628181649952 1.7076510083890373 0.504508253714594 0.33059550733600834 33250840.880173504 12684286.99873999 12250.600277157007 0.11317163615467375 9.323907297118724e-11 10.03040205309976 0.7076881902240421 EGSLLSK(ub)QEESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGSLLSKQEESK 12 1 O00273-2;O00273 O00273-2 DFFA DNA fragmentation factor subunit alpha 1 8047700.0 1442200.0 3851700.0 2753800.0 True False 1866956.3300121103 3637349.5090835886 2252636.6563741164 1.0 1.9482777666577742 1.2065824037563344 20.832256751193697 -10.221621935139154 4.777482551894215 0.9998896472544551 1.577430085208632 0.4469453779599034 0.3027958639552251 0.0003559954017952186 5.8000496801301446e-05 0.2932364225273882 0.09772694486577466 6.003134376212326e-11 10.221621935139154 0.577540437954177 EGSLVINSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGSLVINSK 9 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 3332400.0 1238800.0 0.0 2093600.0 False True 1624078.7965562649 0.0 1876974.3552292816 1.0 0.0 1.1557163108152526 20.63119019978026 -10.684763286582195 4.513929199260948 1.0159405062746125 0.5778581554108609 0.15102473890299928 0.47181920815166545 0.07644448026645531 0.005338605779179836 0.46139531057524275 0.15227899463266178 2.066506203870918e-11 10.684763286582195 -0.4380823508637516 EGSLVINSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGSLVINSK 9 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 4211900.0 1238800.0 1193700.0 1779400.0 False True 1696817.8373112262 1140958.3869619744 1359142.3678933415 1.0 0.6724106512045717 0.8009948610907082 20.69440026130315 -10.199589422765726 4.815253193206849 1.0000368354713494 0.7367027561468412 0.8482680517107113 0.05249428386941507 2.0761564155309562e-05 3.451101262425395e-06 0.050834473462908106 0.0169424572660526 6.315541266764437e-11 10.199589422765726 -0.26333407932450814 EGSLVINSK(ub)NQYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGSLVINSKNQYK 13 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 1 7375400.0 1916800.0 3622400.0 1836200.0 True False 1593904.1286378654 3602885.412209898 2220140.930370446 1.0 2.2604153835079703 1.3928948990600558 20.60413342493969 -10.12097079391745 4.550954880123268 0.9999187165247632 1.826655141304744 0.5476497171981722 0.3541637547941767 248993371.68119875 148110949.54013315 232598.37831730288 0.12961065954721684 7.568837933588333e-11 10.12097079391745 0.8267364247799809 EGSPANWK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGSPANWKR 9 1 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 1 8998200.0 2031100.0 2623800.0 4343300.0 True False 2662791.7692003814 2232339.2674922952 3893896.9798754943 1.0 0.8383454137544716 1.4623362686166053 21.344508183269674 -6.837941636702037 1.2920977000386298 0.9139706730755859 1.4820147860991995 0.9208242268744021 0.07440242157692219 0.17122061883597045 0.5561935407785129 0.04516925923466118 0.1040007702554879 1.4523067748403158e-07 6.837941636702037 0.5680441130236136 EGSPANWK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGSPANWKR 9 1 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 1 25179200.0 3385800.0 4139400.0 17654000.0 True False 5136506.135136015 3400691.728720186 14164679.161976933 1.0 0.6620632078014904 2.7576486407918703 22.29235593741403 -6.865583340259381 1.1572897432924918 0.8131563760304517 2.870456852991695 0.9600681548159069 0.1835703608356752 0.1411552750028328 0.35613385716778156 0.12341042249727982 0.29012201761196776 1.3627514717797205e-07 6.865583340259381 2.0573004769612435 up EGSPANWK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGSPANWKR 9 1 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 1 10170000.0 2031100.0 1933600.0 6205300.0 True False 2782052.558413654 1848167.158439872 4739735.942165086 1.0 0.6643178443378187 1.7036831054218893 21.407718244792566 -6.819766236022433 1.3728938126249262 0.8190282280941955 1.7262592075180323 0.8838478371753389 0.1476031649364343 0.19378191138744455 0.7177561546532288 0.08448793127208984 0.1947425011206885 1.5143761594063974e-07 6.819766236022433 0.9072309794238368 EGSPANWK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGSPANWKR 9 1 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 1 13317400.0 2330800.0 4712300.0 6274300.0 True False 1938163.471947591 4686913.9045816865 7586227.120914554 1.0 2.4182242480671534 3.914131718358837 20.886258827498228 -6.970450940931285 0.24718067427385582 0.5084966598636665 5.8675160654938106 0.9999856886854087 0.004501159368330496 0.0761566566131288 0.008505062783294806 0.03401197078442084 0.1440385194292612 1.0704072921588733e-07 6.970450940931285 5.359019405630144 EGSQLK(ub)QQIQSIQQSIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGSQLKQQIQSIQQSIER 18 1 P55769;B1AHD1;A0A3B3IUA2;A0A3B3IRU2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 15552100.0 3085400.0 6768100.0 5698600.0 True False 4044989.2790561034 5758325.861847169 5108963.53683109 1.0 1.42357011714772 1.263035124291668 21.947704448228354 -10.092746863998011 5.101965542914872 0.9999919294546942 1.3433026207205412 0.8591058025227689 0.06553813639605943 6.016547539193718e-06 1.0698158969905485e-06 0.06345851833312417 0.021152342566527635 8.077056782075953e-11 10.092746863998011 0.343310691265847 EGSQLK(ub)QQIQSIQQSIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGSQLKQQIQSIQQSIER 18 1 P55769;B1AHD1;A0A3B3IUA2;A0A3B3IRU2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 87562000.0 39575000.0 26181000.0 21806000.0 True False 38318713.28725982 36635209.832111366 16094354.434022332 1.0 0.9560657623723451 0.4200129141437892 25.1915457815159 -6.923155192510304 0.8009780924902119 1.0105373985486734 0.3269685409700249 0.9950134128510209 0.01861882910958298 0.0963507723807079 0.09625378300285053 0.016316128630451787 0.050451482826582766 1.1935615162498116e-07 6.923155192510304 -0.6835688575786485 down EGSQLK(ub)QQIQSIQQSIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGSQLKQQIQSIQQSIER 18 1 P55769;B1AHD1;A0A3B3IUA2;A0A3B3IRU2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 69014000.0 13397000.0 20594000.0 35023000.0 True False 20324228.451892372 16918839.798343573 28100688.698873807 1.0 0.8324468423679952 1.3826201946798808 24.276697249980163 -6.825008127561059 1.3502045474327231 0.9101173799361509 1.3959561515596284 0.895476840540128 0.07444206038633981 0.18706327985136892 0.6687064749138533 0.04331071063287624 0.09970941212672413 1.49620765520248e-07 6.825008127561059 0.48583877162347744 EGSQLK(ub)QQIQSIQQSIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGSQLKQQIQSIQQSIER 18 1 P55769;B1AHD1;A0A3B3IUA2;A0A3B3IRU2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 18271400.0 3085400.0 7645200.0 7540800.0 True False 4226155.759799853 7307409.784704436 5759818.347650961 1.0 1.7290914485959477 1.362897790573564 22.010914509751245 -10.102805758919462 4.440153791571131 0.9999532786823894 1.545994619234004 0.7477363520248868 0.1494979350797674 22685201.142386068 25808143.299671378 10125.437658825114 0.051177119783299786 7.892130194386008e-11 10.102805758919462 0.5460413405516146 EGSQLK(ub)QQIQSIQQSIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGSQLKQQIQSIQQSIER 18 1 P55769;B1AHD1;A0A3B3IUA2;A0A3B3IRU2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 89692000.0 39575000.0 35594000.0 14523000.0 True False 32908365.96976401 35402248.05714416 17559692.153234947 1.0 1.075782616787218 0.5335935600500091 24.971951056950175 -6.871533821244829 1.1260157189435809 1.043279964127913 0.5009099098556241 0.9661868808496049 0.04408291721016092 0.13538931060732906 0.31990838851771747 0.030355118910431734 0.07206109854214551 1.3442070807290384e-07 6.871533821244829 -0.5423700542722888 EGSQLK(ub)QQIQSIQQSIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGSQLKQQIQSIQQSIER 18 1 P55769;B1AHD1;A0A3B3IUA2;A0A3B3IRU2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 69271000.0 13397000.0 24166000.0 31708000.0 True False 17342680.594350476 22821140.8563787 25937469.351554405 1.0 1.3158946641624063 1.4955859453470968 24.047823572072613 -10.9782444959305 0.09342883357958327 3.5040895655205494e-17 2.0053476691884025 0.9999135771672422 0.0019043869248293818 3.3246332589202208 0.057070623987292776 1.0443337397701407 0.3290722750805825 1.0513698146949339e-11 10.9782444959305 2.0053476691884025 EGSVLDILK(ub)SPGFASPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGSVLDILKSPGFASPK 17 1 P49790;P49790-3 P49790 NUP153 Nuclear pore complex protein Nup153 1 8854300.0 1589100.0 4600900.0 2664300.0 True False 1538654.8903293612 6438063.363376536 1966439.9027132762 1.0 4.184215319393953 1.2780253161853237 20.55323825073517 -6.624367903650508 2.100468202402848 3.106266474308065 1.289313708399761 0.09777659847251474 1.367792755777854 0.5737781365787193 4.816216121700529 0.5339173782344409 1.5162521070378001 2.3748276477964152e-07 6.624367903650508 -1.816952765908304 EGTEASASK(ub)GLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGTEASASKGLEK 13 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 1774880.0 882490.0 0.0 892390.0 True False 1156952.9360453163 0.0 800054.0432093313 1.0 0.0 0.6915182271320969 20.14189874723972 -10.486847312904981 8.304263188656684 1.0000358412137955 0.34575911629639755 0.5440986876950831 0.2823111340512799 0.00018734309506792903 1.1576402646213555e-05 0.27336142461925966 0.09111552671912802 3.2595127718945775e-11 10.486847312904981 -0.654276724917398 EGTEASASK(ub)GLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGTEASASKGLEK 13 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 2411460.0 722680.0 670880.0 1017900.0 True False 699738.9189750323 938765.8825929827 751281.4536545603 1.0 1.341594496370266 1.073659665457835 19.41645720998084 -10.064712989304034 5.34859704157805 0.9999979355227927 1.2076270809142693 0.44464821580857505 0.10938393667649131 2.6928533796607285e-06 4.7093496866107387e-07 0.10591159386557701 0.03530351375744395 8.6156294221384e-11 10.064712989304034 0.2076291453914766 EGTEASASK(ub)GLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGTEASASKGLEK 13 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 3213400.0 356800.0 1371800.0 1484800.0 True False 541291.6855740238 1126991.5720776808 1191328.6291890407 1.0 2.082041165813474 2.2008995536771865 19.046046702368827 -10.804358226927278 0.4166593699333353 7.145538975995576e-23 2.2076719649140237 0.9994981148001301 0.01210372935385313 2.4378472895819137 0.201391663546843 2.4534795362823734 0.02900353567046424 1.569068027812668e-11 10.804358226927278 2.2076719649140237 EGTEASASK(ub)GLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGTEASASKGLEK 13 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 2393420.0 882490.0 528610.0 982320.0 True False 1208770.401395531 505254.2623204895 750316.2475154476 1.0 0.41799026658592164 0.6207268532131528 20.20510880876261 -10.088469739198228 5.028727636905351 1.0000124476182461 0.5193585598983885 0.8822706051825178 0.08276686491123178 22905657.725510743 45952585.39728144 2115.0336823459097 0.0283333018360459 8.156996215289034e-11 10.088469739198228 -0.4806538877198576 EGTEASASK(ub)GLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGTEASASKGLEK 13 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 2341090.0 356800.0 738290.0 1246000.0 True False 461884.63357947656 697203.5124909311 1019240.7850396346 1.0 1.5094754443069454 2.2066999223178394 18.817173024461276 -6.966736892921487 0.32687322314238293 0.9118986090857276 2.826995219185429 0.9999446014248148 0.0036814390649823154 0.07737640086866346 0.012807704436868622 0.010290061436920442 0.06096919956829052 1.0796005747186665e-07 6.966736892921487 1.9150966100997016 EGTGSTATSSSSTAGAAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGTGSTATSSSSTAGAAGK 19 0 A0A087WZK9;B3KS98;O15372;E5RGU4;E5RHC7;E5RH59;E5RFW7;E5RFH0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 0 10795100.0 3401700.0 1240000.0 6153400.0 False True 3293714.8954964397 1735138.4665145737 4541639.941956937 1.0 0.5268028720054253 1.3788807125251823 21.65128424987271 -6.755959515187279 1.6275383357565363 0.7237633537608901 1.3814009881261697 0.6742948999668342 0.19893031344539552 0.2897685501633585 1.5117824928114791 0.09648063316744 0.2328056483668826 1.7540440057228166e-07 6.755959515187279 0.6576376343652797 EGTGSTATSSSSTAGAAGK(ub)GK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGTGSTATSSSSTAGAAGKGK 21 1 A0A087WZK9;B3KS98;O15372;E5RGU4;E5RHC7;E5RH59;E5RFW7;E5RFH0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 21517500.0 5787700.0 9369900.0 6359900.0 True False 7587730.74816653 7971947.443584131 5701838.556468622 1.0 1.0506365747770428 0.7514550457455798 22.855237054718675 -6.863341036852138 1.1686633490371994 1.027759532335248 0.7360096168964235 0.957577941813723 0.02692904026109101 0.14340391762829652 0.37027609623410507 0.017945412577012466 0.04206255217320912 1.3698056813759356e-07 6.863341036852138 -0.29174991543882445 EGTGSTATSSSSTAGAAGK(ub)GK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGTGSTATSSSSTAGAAGKGK 21 1 A0A087WZK9;B3KS98;O15372;E5RGU4;E5RHC7;E5RH59;E5RFW7;E5RFH0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 30687400.0 9243400.0 10472000.0 10972000.0 True False 8949973.326581348 14653524.210758554 8098104.047055548 1.0 1.6372701544526067 0.9048187912475946 23.093451952073565 -6.676719276615974 1.9134906402016736 1.404399412371618 0.9076761081449322 0.30909873863130966 0.2702882233886718 0.445914364548204 3.153709330585195 0.11346137910382041 0.3005162504907826 2.1051387396111372e-07 6.676719276615974 -0.49672330422668576 EGTGSTATSSSSTAGAAGK(ub)GK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGTGSTATSSSSTAGAAGKGK 21 1 A0A087WZK9;B3KS98;O15372;E5RGU4;E5RHC7;E5RH59;E5RFW7;E5RFH0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 47848900.0 7475100.0 9421800.0 30952000.0 True False 11340273.203011159 7740406.177140598 24834323.6332565 1.0 0.6825590564330765 2.1899228694651107 23.43495206144772 -6.851705713432995 1.2268802198948625 0.8303279245214583 2.2521763610524834 0.9427441835236579 0.15525341423446287 0.1555914192291237 0.4498330010478511 0.09897637724904453 0.22929394123808367 1.4070006127389535e-07 6.851705713432995 1.421848436531025 up EGTGSTATSSSSTAGAAGK(ub)GK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGTGSTATSSSSTAGAAGKGK 21 1 A0A087WZK9;B3KS98;O15372;E5RGU4;E5RHC7;E5RH59;E5RFW7;E5RFH0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 22732200.0 5787700.0 9113800.0 7830700.0 True False 7927569.096711485 8711122.18069368 5981249.938328874 1.0 1.0988390103477281 0.7544872665707849 22.918447116241566 -6.829967821843677 1.3281100561245305 1.0528134016135178 0.7452306418016025 0.9058015693398808 0.044432299791602486 0.18084978078601652 0.6238953874834041 0.026268305175153543 0.06044911753386577 1.4792179837218853e-07 6.829967821843677 -0.3075827598119153 EGTGSTATSSSSTAGAAGK(ub)GK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGTGSTATSSSSTAGAAGKGK 21 1 A0A087WZK9;B3KS98;O15372;E5RGU4;E5RHC7;E5RH59;E5RFW7;E5RFH0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 26749200.0 9243400.0 13053000.0 4452800.0 True False 7686296.652050945 12982680.898182368 5383859.892578983 1.0 1.6890684143342531 0.7004491416737604 22.87385722750784 -6.719298027819356 1.7618920922759993 1.4195394922238127 0.7020579876604075 0.5091561435408319 0.2899883225002526 0.3566954824895817 2.163612723645751 0.1307066630117515 0.32838753181730596 1.9085431011232177e-07 6.719298027819356 -0.7174815045634052 EGTGSTATSSSSTAGAAGK(ub)GK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGTGSTATSSSSTAGAAGKGK 21 1 A0A087WZK9;B3KS98;O15372;E5RGU4;E5RHC7;E5RH59;E5RFW7;E5RFH0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 34856400.0 7475100.0 9762300.0 17619000.0 True False 9676664.306249838 9219019.423248608 14412522.786206516 1.0 0.9527063388252858 1.4894102275406973 23.20607838354017 -6.885420522244976 1.0490727533060538 0.9679177346833523 1.5316370195598588 0.9778024195748696 0.036148616962371476 0.12293830225167675 0.24417224352967462 0.02639971658982339 0.06481955199979428 1.3019055480854213e-07 6.885420522244976 0.5637192848765065 EGTIQVQGQALFFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGTIQVQGQALFFR 14 0 Q96IU4;F8W9U3;B4DQI4 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 12550700.0 5571200.0 3074600.0 3904900.0 False True 5394345.305520699 4302303.813827189 2882089.5455110474 1.0 0.7975581039322993 0.5342797656207602 22.36301644436773 -6.9675200545981015 0.31178549472373546 1.039714435694719 0.2837328905229204 0.9999560676402254 0.0012637723243737304 0.07711591048853239 0.011896304018919716 0.004132418779439351 0.023334014832235205 1.0776554891966642e-07 6.9675200545981015 -0.7559815451717986 EGTIQVQGQALFFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGTIQVQGQALFFR 14 0 Q96IU4;F8W9U3;B4DQI4 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 69908000.0 17893000.0 33849000.0 18166000.0 False True 27144989.153520193 27808381.486555874 14575482.137559352 1.0 1.024438850547474 0.5369492710100857 24.694182571612874 -6.895102525270626 0.9917346630016418 1.023080302066914 0.49058139975827486 0.9839674362112989 0.02839657493137018 0.11509972715037463 0.19845729517500107 0.021657908950586748 0.05508432420841052 1.2732024766040266e-07 6.895102525270626 -0.532498902308639 EGTIQVQGQALFFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGTIQVQGQALFFR 14 0 Q96IU4;F8W9U3;B4DQI4 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 6120800.0 1454400.0 1551700.0 3114700.0 False True 1992130.9836821493 1483140.763214287 2379072.009260082 1.0 0.744499621442024 1.1942347309225279 20.925881077822595 -6.752604781158685 1.6401437535156895 0.8502291814949854 1.1953105138418247 0.6600537444614931 0.10738049473006638 0.295561019438551 1.5650733559656056 0.05170063975466838 0.12517685634326936 1.7676456907660103e-07 6.752604781158685 0.34508133234683935 EGTIQVQGQALFFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGTIQVQGQALFFR 14 0 Q96IU4;F8W9U3;B4DQI4 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 10875200.0 5571200.0 2198100.0 3105900.0 False True 4632699.6460075565 2186258.3990113125 3755329.329940951 1.0 0.47191887367345775 0.8106135983102811 22.143421719802006 -10.474787762679032 6.897951797659925 1.000085483748477 0.6412662359918752 0.5993229162948123 0.13827154232211197 0.0001818197979542346 1.3843840248467168e-05 0.13391250089971093 0.044626948388996134 3.35129174927892e-11 10.474787762679032 -0.3588192477566018 EGTIQVQGQALFFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGTIQVQGQALFFR 14 0 Q96IU4;F8W9U3;B4DQI4 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 61169000.0 17893000.0 29031000.0 14245000.0 False True 23162841.223760013 27415399.329700023 11652556.166043034 1.0 1.1835939755774787 0.5030711065829894 24.465308893705323 -6.83486855364277 1.305964332045484 1.0978208805148941 0.4828617582735692 0.9152753427857423 0.08367563687007994 0.1748774861991055 0.5815673564254772 0.05027860522748311 0.11572397565638139 1.462619793371007e-07 6.83486855364277 -0.6149591222413249 EGVFAK(ub)EVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGVFAKEVR 9 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 5108500.0 1050500.0 1664400.0 2393600.0 True False 1377215.6730564728 1416078.0077803845 2145933.233032484 1.0 1.0282180456439796 1.558167885404605 20.393323073666007 -6.917911801568932 0.8400547367742383 0.9874044037852805 1.6396569120350681 0.9935813438958561 0.020568344247854378 0.09941586034415777 0.11209074773457099 0.017528589440943213 0.051503652119502016 1.2080591481546417e-07 6.917911801568932 0.6522525082497876 EGVFAK(ub)EVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGVFAKEVR 9 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 17582900.0 2742900.0 2717000.0 12123000.0 True False 4161179.8328503077 2232130.1219821065 9726883.736300347 1.0 0.5364176054975137 2.3375302503178927 21.988561207708067 -6.838398618397793 1.2898081319546388 0.75331178870432 2.394918347083233 0.921667911428728 0.2137181862909523 0.17067596773138602 0.5522420098562769 0.12996217195765236 0.2992921390013681 1.4507794043831924e-07 6.838398618397793 1.6416065583789128 up EGVFAK(ub)EVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGVFAKEVR 9 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 4639200.0 1050500.0 1044700.0 2544000.0 True False 1438898.238695064 998541.6996390828 1943159.5953246397 1.0 0.6939626950580324 1.3504496308834806 20.4565331351889 -6.779942062394504 1.5359884329881552 0.8266949040760174 1.3556485587836016 0.7671788246382722 0.1294174156669801 0.2506874686845056 1.1681827397159816 0.0663606776498298 0.15659798816780257 1.6598083214998943e-07 6.779942062394504 0.5289536547075842 EGVFAK(ub)EVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGVFAKEVR 9 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 12812900.0 2742900.0 2059500.0 8010500.0 True False 3550738.120642226 1944887.0145539995 6552671.194670943 1.0 0.5477416099056681 1.845439165613755 21.759687529800516 -6.812577079743616 1.40381213794289 0.7542667242549146 1.869475811239731 0.8664190392999843 0.1965690486645412 0.2033061241415968 0.789170709486784 0.11009084548953513 0.25436181879136965 1.5396532400426473e-07 6.812577079743616 1.1152090869848164 EGVHGGLINK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGVHGGLINK 10 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 50846000.0 4755000.0 28628000.0 17463000.0 False True 6233851.047485501 24356813.991069965 15656096.276924396 1.0 3.907185751718367 2.5114646079391765 22.571692252740885 -9.909400793795982 14.689849248987102 1.0000001580423976 3.2093251798287716 0.769631894264178 0.5698007709121293 0.0 0.0 0.5517072158786259 0.1839024080332342 1.2319673727984052e-10 9.909400793795982 2.2093250217863742 EGVHGGLINK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGVHGGLINK 10 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 30986300.0 9737000.0 4100300.0 17149000.0 False True 9427904.26476434 5737571.172782019 12657162.441027658 1.0 0.608573338427449 1.3425213160396932 23.168505678203836 -6.761851930545372 1.6057093731871481 0.7731557983126711 1.3454296668112282 0.6983776427649551 0.1646806442336063 0.2798304630027805 1.4224195674791056 0.08090755491123476 0.19406338364760672 1.7304062277118506e-07 6.761851930545372 0.5722738684985571 EGVHGGLINK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGVHGGLINK 10 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 41022000.0 4755000.0 16511000.0 19756000.0 False True 6513051.9990433315 15781489.425424457 15090039.687591787 1.0 2.423055954066161 2.3168922480287715 22.634902314263776 -10.208055465354825 4.422973630256934 0.9995707354524465 2.369974101042812 0.9955162945601642 0.04334115160069092 15245976.97735857 52.47364397969961 66841.72355084712 0.014836828984820097 6.1936196901722e-11 10.208055465354825 1.3704033655903656 EGVHGGLINK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGVHGGLINKK 11 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 241117200.0 96462000.0 107357000.0 37298200.0 True False 126462616.13933684 91339754.07430841 33438940.053597946 1.0 0.7222668395035418 0.26441758896364154 26.914135729146565 -7.085709473342643 0.4087347376020552 1.0247869919706485 2.087066301184877e-16 0.9998153996796152 0.004120676949891013 0.07514964754197433 0.019946242332181747 0.00656303602543408 0.03689450846829392 8.209005122259792e-08 7.085709473342643 -1.0247869919706483 down EGVHGGLINK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGVHGGLINKK 11 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 397687100.0 173171000.0 157673000.0 66843100.0 True False 167673781.39401284 220632651.15383276 49334886.859983474 1.0 1.31584466766079 0.2942313726679339 27.321081876087 -6.82365882816567 1.3558670933893946 1.1696321024996448 0.2701037962680955 0.8926376331277339 0.13993723472532385 0.18874939635273946 0.6807828055508252 0.08108182245548139 0.18673298094510116 1.5008634165587315e-07 6.82365882816567 -0.8995283062315493 down EGVHGGLINK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGVHGGLINKK 11 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 189796200.0 67672700.0 54444200.0 67679300.0 True False 102664433.43706611 44728207.13552381 54302456.69010909 1.0 0.4356738320963166 0.5289315381397084 26.613361227113064 -10.819603901194887 7.33551421130087 1.0245910892449976 0.4823026851180137 0.9762405839008913 0.038072299064796165 0.013679272057740489 0.00033640233453206727 0.03293354118383029 0.012287781685815307 1.5149423235050364e-11 10.819603901194887 -0.542288404126984 EGVHGGLINK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGVHGGLINKK 11 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 218328300.0 96462000.0 90443000.0 31423300.0 True False 132126608.18753274 86446929.20499438 24001763.723177932 1.0 0.6542734305439575 0.18165730621882945 26.977345790669457 -7.404640008990739 0.4374441053725749 1.0246066838791665 6.823121833695974e-27 0.99880588049159 0.011590889131175007 0.11174601069045939 0.046914334553729835 0.016058034311323965 0.06126623816253259 3.938764282617341e-08 7.404640008990739 -1.0246066838791665 down EGVHGGLINK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGVHGGLINKK 11 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 405383000.0 173171000.0 202305000.0 29907000.0 True False 143999359.27605793 201215142.81060162 36160415.42565565 1.0 1.3973335980256454 0.2511151133411179 27.101487151521276 -6.813079923224534 1.4014161221547066 1.215774721336643 0.22959443889516065 0.8677354946907154 0.17282945015463025 0.20263893965733318 0.7837502496262643 0.09695125018860642 0.22398567229407254 1.5378715997102983e-07 6.813079923224534 -0.9861802824414824 down EGVHGGLINK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGVHGGLINKK 11 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 135825500.0 67672700.0 64337000.0 3815800.0 True False 87603644.17834586 60756589.39323174 3121363.5534143164 1.0 0.6935395206795489 0.03563052179724122 26.384487549205513 -7.415760350387696 0.6827842531929598 0.99500586583288 1.3851387817392573e-15 0.9914615421546108 0.0371761205977621 0.11173735198760568 0.11233175415323557 0.03328096496141795 0.07060277986019234 3.839190388081327e-08 7.415760350387696 -0.9950058658328786 down EGVHGGLINKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGVHGGLINKK 11 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 20747750.0 2095950.0 11903700.0 6748100.0 False True 2747810.7472086735 10127714.360259172 6049871.344345957 1.0 3.6857394092905684 2.2017059764729567 21.38985121268478 -9.738492809332131 6.375830461156965 0.9999999830268838 2.9437226928835867 0.6957974471524221 0.6058541119455428 1.5169413111332783e-07 3.0161972604091424e-08 0.5866157301874205 0.19553857381540185 1.8260269825810304e-10 9.738492809332131 1.943722709856703 EGVHGGLINKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGVHGGLINKK 11 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 14590560.0 5767000.0 3027200.0 5796360.0 False True 5583929.741696206 4235976.746639451 4278119.428927351 1.0 0.7586013690338279 0.7661485059494687 22.412849358661113 -10.657885746707542 6.56862898315934 1.0013448400817493 0.7623749374916483 0.9992440130259626 0.0030811057437070666 6.0999379099339035e-05 3.1770281424798853e-06 0.0029989127847327014 0.0009944226027734531 2.198438157269883e-11 10.657885746707542 -0.23896990259010098 EGVHGGLINKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGVHGGLINKK 11 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 17796600.0 452840.0 16573000.0 770760.0 False True 686991.3870385105 13615418.664559966 618418.9481638916 1.0 19.818907371245878 0.9001844270999936 19.38993248620985 -6.472310289096378 2.761046089338095 9.999999999999998 0.8514968002395632 0.2518980069641046 7.693488987629341 0.62419113228198 8.878626131972002 2.971036534849312 10.519817566698077 3.370464140570526e-07 6.472310289096378 -9.148503199760436 EGVHGGLINKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGVHGGLINKK 11 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 18170850.0 2095950.0 8279100.0 7795800.0 False True 2870879.3559190067 7913301.986677461 5954592.599540807 1.0 2.756403528543368 2.0741354342403784 21.45306127420767 -10.374038219918488 5.663146667134126 0.9995964235896929 2.415269481391879 0.8515723950948176 0.278534783137254 0.0014196340936170576 0.00015691588749047454 0.26975948669681105 0.08989671470250357 4.226314191138124e-11 10.374038219918488 1.415673057802186 EGVHGGLINKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGVHGGLINKK 11 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 8792050.0 5767000.0 2629280.0 395770.0 False True 4795516.021418295 2615115.5467687813 478523.677166274 1.0 0.5453251610648043 0.09978564872456594 22.19325463409539 -7.828045141893957 0.4541813949537397 1.0334638188897909 6.234334876110138e-17 0.9964672284499791 0.021844168751883164 0.11026312069133401 0.09083887154290476 0.03431163475739883 0.07826210823237559 1.4857811976279934e-08 7.828045141893957 -1.0334638188897909 down EGVHGGLINKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGVHGGLINKK 11 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 2136560.0 452840.0 1087860.0 595860.0 False True 586210.3068109021 1027319.6346942048 487419.5940399017 1.0 1.7524762406226242 0.8314756468400546 19.1610588083023 -6.689470440225478 1.8679858024522424 1.4719727786925605 0.8346471320657732 0.36813317155632974 0.31827613716824876 0.4177811432460213 2.82591287031319 0.13631710457497495 0.35525716574132155 2.0442290694624677e-07 6.689470440225478 -0.6373256466267873 EGVK(ub)TENDHINLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGVKTENDHINLK 13 1 A8MUA9;A8MU27;P55854;P55854-2 A8MUA9 SUMO3 Small ubiquitin-related modifier 3 1 11213700.0 3146200.0 3198100.0 4869400.0 True False 4124698.6678441404 2720955.9460961632 4365561.198583041 1.0 0.6596738732234051 1.0583951823236564 21.975857295643532 -6.680661318710997 1.8994272777344203 0.7847992002193421 1.0568887867638639 0.32716973032642604 0.14421761364740424 0.4370749379815325 3.0493011231371594 0.06091013532563464 0.1605168980257873 2.0861170916632407e-07 6.680661318710997 0.27208958654452176 EGVK(ub)TENDHINLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGVKTENDHINLK 13 1 A8MUA9;A8MU27;P55854;P55854-2 A8MUA9 SUMO3 Small ubiquitin-related modifier 3 1 12489800.0 3146200.0 2584400.0 6759200.0 True False 4309435.162858073 2470212.6625320674 5162816.170093666 1.0 0.573210309281876 1.1980261855638685 22.039067357166424 -6.722819872805296 1.7491457031477418 0.7411318002989126 1.1972116573210443 0.5257992911134394 0.179535327406656 0.34986817333467907 2.0934268903554196 0.08145141588704916 0.20380024623065224 1.8931286464525808e-07 6.722819872805296 0.4560798570221317 EGVK(ub)TENNDHINLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGVKTENNDHINLK 14 1 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 1 47518600.0 9471700.0 5735900.0 32311000.0 True False 12417490.424073286 4880126.078363081 28967767.66899754 1.0 0.393004215159464 2.3328198113878873 23.565870298432042 -6.822621623542441 1.360598560950217 0.6736823799592042 2.3775627271127306 0.8902941648689798 0.2683515997526626 0.19009001474157344 0.6907539844514378 0.1549647600105159 0.3569249439068786 1.5044521401529353e-07 6.822621623542441 1.7038803471535264 up EGVK(ub)TENNDHINLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGVKTENNDHINLK 14 1 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 1 152416900.0 20807900.0 33403000.0 98206000.0 True False 20147364.604168594 46740992.09434387 72482902.48315136 1.0 2.3199556375067 3.5976369072188366 24.26408780216315 -6.971523037226351 0.2187715541553162 0.40157346487452616 5.552045886382697 0.9999919496112064 0.003009051484995599 0.07581150717668542 0.0072353630225786255 0.035725909088123155 0.12983865613346285 1.0677681510894888e-07 6.971523037226351 5.15047242150817 EGVK(ub)TENNDHINLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGVKTENNDHINLK 14 1 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 1 272916000.0 44967000.0 41829000.0 186120000.0 True False 68218226.52804692 34364288.1385313 149333300.4207059 1.0 0.5037405674039757 2.189052809212355 26.023653913849905 -6.827872084424868 1.3376015047313248 0.7344272476152801 2.232395914281536 0.9015094111559949 0.2219226055634452 0.18345433890839458 0.6427158634480132 0.1303013669664877 0.2998658398370306 1.4863733690251372e-07 6.827872084424868 1.4979686666662562 up EGVK(ub)TENNDHINLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGVKTENNDHINLK 14 1 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 1 60974900.0 9471700.0 15958200.0 35545000.0 True False 12973643.453068092 15253113.957289593 27150003.072254024 1.0 1.1757001040199264 2.092704579902218 23.629080359954933 -6.938853748004283 0.6701501969850083 0.9894746052788699 2.3318639150809384 0.9980097793655289 0.021373243499275572 0.08829360494323103 0.0570220096525513 0.020628742494600644 0.0793317094801214 1.1511879950574811e-07 6.938853748004283 1.3423893098020685 up EGVK(ub)TENNDHINLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGVKTENNDHINLK 14 1 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 1 108188900.0 20807900.0 38036000.0 49345000.0 True False 17302690.79626661 37831092.51844508 59662811.354498334 1.0 2.1864282823922316 3.4481810983625585 24.044493077597426 -6.970344310747069 0.2498264654471175 0.5987230043525202 5.072833223826545 0.9999849447584267 0.003878643000269748 0.07619114570296594 0.008629514812542687 0.028174895823301734 0.12096131991922919 1.0706701362531225e-07 6.970344310747069 4.474110219474024 EGVK(ub)TENNDHINLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGVKTENNDHINLK 14 1 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 1 978581000.0 44967000.0 54744000.0 878870000.0 True False 58210667.93208615 51697448.2761564 718924677.967725 1.0 0.8881095186276052 12.35039389698273 25.794780235942355 -6.904696873526206 0.9311071756539935 0.5828869462947367 13.675178132637978 0.9887613903080587 0.5700487378268309 0.10802978090363943 0.1585675823002748 0.4547996437169017 1.213768065250981 1.2453835544497297e-07 6.904696873526206 13.09229118634324 up EGVLTGSPEQK(ub)EEAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGVLTGSPEQKEEAAK 16 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 4665500.0 1008800.0 1602300.0 2054400.0 True False 1322546.569233097 1363243.0857164802 1841830.3951963284 1.0 1.0307713296681733 1.3926393505102417 20.334887092433817 -6.923684997525143 0.7968989301902022 0.9930259722400719 1.45624872613035 0.9951453906001767 0.012421818238651046 0.09605117744377906 0.0947253425514313 0.010917238314628219 0.03395014483812452 1.1921063531095415e-07 6.923684997525143 0.4632227538902781 EGVLTGSPEQK(ub)EEAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGVLTGSPEQKEEAAK 16 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 45353600.0 6802200.0 7969400.0 30582000.0 True False 10319434.707431689 6547198.3047936 24537454.295433246 1.0 0.6344531934562793 2.377790546778909 23.298860607150797 -6.851970252316891 1.2256514669862753 0.8045646214795316 2.4501334189140853 0.9431087744563503 0.17904198807461308 0.15530490048805692 0.4479785475613039 0.11424996397636165 0.26471835309614844 1.4061438368634426e-07 6.851970252316891 1.6455687974345539 up EGVLTGSPEQK(ub)EEAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGVLTGSPEQKEEAAK 16 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 4288000.0 1008800.0 1318500.0 1960700.0 True False 1381780.621794935 1260244.3103035612 1497623.0418840472 1.0 0.912043699575481 1.083835609113285 20.39809715395671 -6.767557837109457 1.5840186927547901 0.9493921860005986 1.0847087569794758 0.7210316548528275 0.037046414590372424 0.2704084629948495 1.3386707347444167 0.01843961532545232 0.043989152526959036 1.707820266179274e-07 6.767557837109457 0.13531657097887717 EGVLTGSPEQK(ub)EEAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGVLTGSPEQKEEAAK 16 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 48208100.0 6802200.0 5796900.0 35609000.0 True False 8805581.99140784 5474297.419115361 29128527.37919452 1.0 0.6216849067394952 3.3079616324755206 23.069986929243246 -6.871232050805482 1.1274842917288241 0.784332661534067 3.469061598763784 0.96590111003784 0.21923473723933387 0.13568280702735952 0.3216062649261113 0.15078295182680976 0.3577882963943262 1.3451414304421226e-07 6.871232050805482 2.6847289372297167 up EGVMVAK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGVMVAKK 8 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;P46783;Q9NQ39;Q15149 A0A1W2PQS6;P46783;Q15149 RPS10;RPS10P5;PLEC 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like;Plectin 1 7288500.0 1741200.0 1753900.0 3793400.0 True False 2641527.698770992 1440902.8417167517 3043632.8272937187 1.0 0.5454808754748822 1.152224460379428 21.332941107236422 -6.70614034503494 1.808396376499089 0.7194980014156273 1.150683711025313 0.4471239075011798 0.19164879431109036 0.38282763597417874 2.4378682194668606 0.08440383750728676 0.21548055099511826 1.9672504574288904e-07 6.70614034503494 0.4311857096096857 EGVMVAK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGVMVAKK 8 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;P46783;Q9NQ39;Q15149 A0A1W2PQS6;P46783;Q15149 RPS10;RPS10P5;PLEC 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like;Plectin 1 4859300.0 1741200.0 1703400.0 1414700.0 True False 2254017.7241832525 1608604.29259106 1157239.1160478112 1.0 0.7136608888796298 0.5134117197180155 21.10406742932887 -7.834772311024831 0.12724886467514554 1.3954264735880761 1.3987828929148441e-12 0.9999815091626576 0.0008586348579053479 0.1271336754368102 0.01782233279148668 0.07913013308599576 0.10271383433145101 1.4629439558054254e-08 7.834772311024831 -1.3954264735866773 EGVVECSFVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGVVECSFVK 10 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 44435500.0 5899500.0 19866000.0 18670000.0 False True 7734301.630839261 16902070.237061474 16738207.495285962 1.0 2.185338902437841 2.1641524075742145 22.882839598657025 -10.073353606173997 4.961921885465872 0.9999703519028011 2.174745655013166 0.9997561144566117 0.00864935033371762 2.836887861985426e-06 5.298130537889047e-07 0.008374907848922258 0.0027915658129675394 8.445908922109966e-11 10.073353606173997 1.174775303110365 EGVVECSFVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGVVECSFVK 10 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 16882100.0 9761700.0 1947900.0 5172500.0 False True 9451820.176784435 2725706.6281643067 3817667.078326176 1.0 0.2883790187692301 0.4039081369430971 23.17216075126721 -9.938644436474984 5.735338037740554 1.0000005348714718 0.3461435778695944 0.9771214782981573 0.04716456499530941 3.2259255891268144e-07 5.962101275469286e-08 0.04566693145343668 0.01522229789619994 1.151742952591226e-10 9.938644436474984 -0.6538569570018774 EGVVECSFVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGVVECSFVK 10 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 52561500.0 5899500.0 16280000.0 30382000.0 False True 8080704.577992872 15560695.769239282 23206397.336931244 1.0 1.925660766218028 2.8718284541835546 22.946049660179916 -6.9708515899550525 0.2369660131251731 0.6472148238266522 4.177538761919798 0.9999882838342772 0.0026157172847529764 0.07602732652399462 0.00803481578629996 0.023111059857590505 0.09274793566293726 1.0694202663074625e-07 6.9708515899550525 3.5303239380931455 EGVVYVEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGVVYVEVR 9 0 P00813;F5GWI4;F5GXW0 P00813 ADA Adenosine deaminase 0 7145800.0 2385400.0 2252700.0 2507700.0 False True 2309676.7827019463 3152214.8576753093 1850858.140612577 1.0 1.3647861385988953 0.8013494158465645 21.1392595436413 -6.731902975493386 1.7160593777432824 1.2190537445538685 0.8015505379214762 0.5682002880837704 0.15332549639738471 0.332665870755462 1.920039325788044 0.07077622902035122 0.17526486722509016 1.8539457619516676e-07 6.731902975493386 -0.41750320663239227 EGVVYVEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGVVYVEVR 9 0 P00813;F5GWI4;F5GXW0 P00813 ADA Adenosine deaminase 0 12056300.0 2420500.0 6365800.0 3270000.0 False True 3672075.4622531463 5229773.25377759 2623683.066708088 1.0 1.4242009205793 0.7144959556735863 21.808164276196738 -6.744849901450242 1.6691946255117072 1.2509773697187203 0.7136467127603697 0.6263742840740631 0.17822458491673476 0.30912632451655264 1.692930303397077 0.08441152872554344 0.20602548694983688 1.7994927387796556e-07 6.744849901450242 -0.5373306569583506 EGYAWAEDK(ub)EHCEEYGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGYAWAEDKEHCEEYGR 17 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 38529300.0 3268500.0 4798800.0 30462000.0 True False 4958553.459357333 3942416.6468044724 24441172.348031122 1.0 0.7950739422531989 4.929093242285803 22.241487879172947 -6.895240915425619 0.9908847821150915 0.8049682302101463 5.323393506480542 0.9840455212549437 0.24028583007496676 0.11499294768905385 0.1978423149175376 0.18338112409520443 0.4666860706442618 1.2727968287657698e-07 6.895240915425619 4.518425276270396 up EGYAWAEDK(ub)EHCEEYGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGYAWAEDKEHCEEYGR 17 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 35800900.0 3268500.0 4073400.0 28459000.0 True False 4231137.68176715 3846711.709193619 23279754.01399918 1.0 0.9091435917507241 5.502008151215799 22.012614201265396 -6.902388288600356 0.9460455863135577 0.8213563123367796 6.008189326431753 0.987717514777314 0.2376120711728462 0.10966861016581766 0.16767084243129585 0.18749384350726625 0.4939403816833188 1.2520212827943638e-07 6.902388288600356 5.186833014094974 up EGYGLSWNPNLSGHLLSASDDHTICLWDISAVPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGYGLSWNPNLSGHLLSASDDHTICLWDISAVPK 34 0 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 429692600.0 112540600.0 156520000.0 160632000.0 False True 170732318.01993278 128587783.10365821 128883014.79249333 1.0 0.7531543213080827 0.7548835293002137 27.347160931899047 -9.844353347043416 5.905488789518019 1.0000000368335298 0.7540189253037864 0.9999629348899643 0.0007059462079322603 3.4246664933331065e-10 6.640218385804817e-11 0.0006835295728558569 0.00022784315869829518 1.431023128435247e-10 9.844353347043416 -0.24598111152974333 EGYGLSWNPNLSGHLLSASDDHTICLWDISAVPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGYGLSWNPNLSGHLLSASDDHTICLWDISAVPK 34 0 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 210315600.0 112540600.0 40047000.0 57728000.0 False True 145686025.2068791 37818349.24585772 47222096.3393002 1.0 0.2595880366161022 0.3241360746320261 27.118287253991497 -10.087852892638786 5.526232339737029 1.0000064473460926 0.2918620557009315 0.9938071046420677 0.026351626173635064 2.093265446710889e-06 3.455163821427295e-07 0.025515084455717648 0.008504950776209455 8.168590168837345e-11 10.087852892638786 -0.7081443916451611 EGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPK 34 0 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 0 131880000.0 38963000.0 45797000.0 47120000.0 False True 59109719.576851614 37624167.53640585 37806711.3465703 1.0 0.636514059037088 0.6396022789012868 25.81689204050927 -10.234177445660253 5.440834004697559 1.0000246560896184 0.638058170177538 0.9999454008949477 0.0012607604802393505 3.770984922852386e-07 5.308013750372369e-08 0.001220809118543253 0.00040690869527884057 5.832067667892821e-11 10.234177445660253 -0.36196648591208047 EGYLLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGYLLKR 7 1 O95294-2;O95294;O95294-4;O95294-3 O95294-2 RASAL1 RasGAP-activating-like protein 1 1 7190700.0 1636200.0 2741800.0 2812700.0 True False 2145074.044983338 2332734.127452694 2521668.785323556 1.0 1.0874841979969103 1.1755625831289862 21.032596017742016 -6.971041214275954 0.2319736530604041 0.9650516962589104 1.300517738084666 0.9999893973021688 0.00023330950165044117 0.07596627857478169 0.007810717073580786 0.0022305854973824818 0.008714760025685928 1.0689534313939253e-07 6.971041214275954 0.33546604182575557 EGYLLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGYLLKR 7 1 O95294-2;O95294;O95294-4;O95294-3 O95294-2 RASAL1 RasGAP-activating-like protein 1 1 14738700.0 2815200.0 3226600.0 8696900.0 True False 2725833.0169625725 4514998.206496713 6418920.988592542 1.0 1.6563737317731326 2.354847471818072 21.378265755466295 -6.970336303905164 0.25002305194292246 0.7784000147550337 3.253279150902939 0.9999848881658238 0.0021505110759285143 0.07619370615923979 0.00863880417322672 0.015576120994460782 0.06693952527593 1.0706898757752579e-07 6.970336303905164 2.4748791361479054 EGYLLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGYLLKR 7 1 O95294-2;O95294;O95294-4;O95294-3 O95294-2 RASAL1 RasGAP-activating-like protein 1 1 22768100.0 2964300.0 4303800.0 15500000.0 True False 4497059.819358402 3535753.264257117 12436418.206108673 1.0 0.7862366537880666 2.765455365430959 22.100550644017723 -6.880153716667583 1.0788955194800565 0.8672284778359785 2.906161334554555 0.9738111849163144 0.1435318262830183 0.12749613257067538 0.27143877291372825 0.10246303480159703 0.24788839887900144 1.3177902298069025e-07 6.880153716667583 2.038932856718577 up EGYLLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGYLLKR 7 1 O95294-2;O95294;O95294-4;O95294-3 O95294-2 RASAL1 RasGAP-activating-like protein 1 1 7406500.0 1636200.0 1899300.0 3871000.0 True False 2241147.3566424176 1815382.6458548002 2956749.52574751 1.0 0.8100237766491721 1.3193017036493193 21.095806079264907 -6.805720213928568 1.4327828178189421 0.8959290475837297 1.3273369876597594 0.8482611411633143 0.08185510210342423 0.2127032312772377 0.8614133905296444 0.04493535931772453 0.1041447021733902 1.564154995630156e-07 6.805720213928568 0.4314079400760297 EGYLLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGYLLKR 7 1 O95294-2;O95294;O95294-4;O95294-3 O95294-2 RASAL1 RasGAP-activating-like protein 1 1 14811600.0 2815200.0 5834800.0 6161600.0 True False 2340963.5345061175 5803366.774282875 7449962.071980474 1.0 2.479050480172146 3.1824340542545966 21.15867103090057 -9.233981338897335 0.24032626336739554 5.8141297338147e-24 3.680795010364538 0.999201655734049 0.025699022700703365 0.6600767337279185 0.08838444968886983 0.8442012272859297 0.316389429785161 5.834701747348338e-10 9.233981338897335 3.680795010364538 EGYLTK(ub)QGGLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EGYLTKQGGLVK 12 1 Q9UN19;J3KNB3;Q9UN19-2 Q9UN19 DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 1 6823200.0 1279900.0 2467800.0 3075500.0 True False 1677961.2945692325 2099613.859409059 2757276.7622791603 1.0 1.251288612082124 1.6432302528092644 20.67827800692727 -6.964600364530645 0.36484904746575936 0.9680431700056676 1.9400088686209076 0.9999046646958488 0.002584343953066222 0.0780968689654261 0.015339921587668816 0.0052101678954592995 0.03338221572534688 1.0849247968477088e-07 6.964600364530645 0.97196569861524 EGYLTK(ub)QGGLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EGYLTKQGGLVK 12 1 Q9UN19;J3KNB3;Q9UN19-2 Q9UN19 DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 1 11551400.0 1494700.0 2516200.0 7540500.0 True False 1447251.566657414 3520931.7818096527 5565416.839848916 1.0 2.4328401937346875 3.84550755934081 20.464884287616762 -6.971299766381432 0.22498570809638074 0.3881960865508284 5.93027541978146 0.9999908225277179 0.0035192386016785876 0.07588316066407297 0.007503122967406956 0.03767787098263517 0.14170895156916682 1.0683172319524284e-07 6.971299766381432 5.542079333230632 EGYLTK(ub)QGGLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EGYLTKQGGLVK 12 1 Q9UN19;J3KNB3;Q9UN19-2 Q9UN19 DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 1 78091800.0 3952100.0 6581700.0 67558000.0 True False 5995624.637211601 5407144.211943186 54205131.68827668 1.0 0.9018483542788794 9.040781397797108 22.515478633900027 -6.904169929343727 0.9345137971860354 0.6992285668223868 9.97134248307011 0.9885295399547764 0.4084594893775505 0.10840112787318959 0.1606084906713215 0.3250567451430035 0.8648998842470953 1.2468955375190935e-07 6.904169929343727 9.272113916247724 up EGYLTK(ub)QGGLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EGYLTKQGGLVK 12 1 Q9UN19;J3KNB3;Q9UN19-2 Q9UN19 DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 1 6502300.0 1279900.0 1183700.0 4038700.0 True False 1753113.617996965 1131400.2200275508 3084842.239637425 1.0 0.6453661693189298 1.7596362311999139 20.74148806845016 -6.821124977467159 1.3672165942841799 0.8090695448785785 1.7845081836663168 0.8868925436557963 0.1563213511574994 0.19203451962945178 0.7050752794741157 0.08984477839336874 0.2069960423571577 1.5096456590268985e-07 6.821124977467159 0.9754386387877383 EGYLTK(ub)QGGLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EGYLTKQGGLVK 12 1 Q9UN19;J3KNB3;Q9UN19-2 Q9UN19 DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 1 8408600.0 1494700.0 2300700.0 4613200.0 True False 1242909.276437301 2288305.6724468046 5577798.790973176 1.0 1.8410882562611874 4.487695841293812 20.24528956305104 -6.950372979478415 0.5547332578849243 0.9643837386789988 5.489747945230991 0.9992302328721024 0.0412308923975675 0.08333630852601195 0.035345130591965 0.044483728621312196 0.2197618107199464 1.1210552594569415e-07 6.950372979478415 4.525364206551992 EGYLTK(ub)QGGLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EGYLTKQGGLVK 12 1 Q9UN19;J3KNB3;Q9UN19-2 Q9UN19 DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 1 74877800.0 3952100.0 8678700.0 62247000.0 True False 5116071.357537694 8195722.715809568 50918684.70815587 1.0 1.6019562947914148 9.952692437163824 22.286604955992477 -6.921408329380186 0.8142137368631048 0.824931500115843 11.34393278580994 0.9945632414504015 0.301267925879832 0.09735028775157208 0.10137240355529306 0.2615275295889881 0.7942638702253944 1.198372048151546e-07 6.921408329380186 10.519001285694097 up EHALAQAELLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHALAQAELLKR 12 1 A0A087WXB0;O15126;A0A087WTX8;A0A087WZA6;O15126-2 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 23364700.0 9216200.0 7431800.0 6716700.0 True False 12082527.449807758 6323004.408929514 6021720.315135901 1.0 0.5233180255700655 0.498382506487226 23.52641893658169 -13.979312100233194 0.42063478720759323 9.999999999624306 0.49758022417933323 0.9998646672144454 0.0026850902159185766 29.501867684646346 0.2162376555788625 243.95595838346767 0.006042898569437181 1.0487884592162285e-14 13.979312100233194 -9.502419775444972 EHALAQAELLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHALAQAELLKR 12 1 A0A087WXB0;O15126;A0A087WTX8;A0A087WZA6;O15126-2 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 13941000.0 7045000.0 6896000.0 0.0 True False 6821360.331238034 9649608.762164919 0.0 1.0 1.4146164831632013 0.0 22.70162804280099 -6.85456889451522 1.39574664278195 1.2198225838041925 5.3736056461928216e-21 0.9014350008074354 0.18641391743433863 0.17035857391932702 0.667052573739526 0.1075255724885141 0.22586859586410693 1.3977551641678347e-07 6.85456889451522 -1.2198225838041925 down EHALAQAELLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 EHALAQAELLKR 12 1 A0A087WXB0;O15126;A0A087WTX8;A0A087WZA6;O15126-2 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 38444000.0 22162000.0 16282000.0 0.0 True False 33621374.2592251 13376349.88815337 0.0 1.0 0.39785256203449626 0.0 25.00287535953067 -8.289648650444267 0.5359854018650698 1.0330160323503776 8.094177930921242e-17 0.9919310402905773 0.036926088213503495 0.14833272726523522 0.17652858073611447 0.05947880567940255 0.07128053057170246 5.132764630126565e-09 8.289648650444267 -1.0330160323503776 EHALAQAELLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHALAQAELLKR 12 1 A0A087WXB0;O15126;A0A087WTX8;A0A087WZA6;O15126-2 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 19943800.0 9216200.0 6397800.0 4329800.0 True False 12623678.198440203 6115124.041304607 3307190.4150301204 1.0 0.4844169777759543 0.2619831053233566 23.58962899810458 -11.19254670802204 0.15881753777497226 2.0722367193241658 5.527129970842653e-22 0.9995937543944954 0.006230386027701909 3.55219739449963 0.09446964540562394 1.5522950242988536 0.19144615757042294 6.418791842059267e-12 11.19254670802204 -2.0722367193241658 EHALAQAELLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHALAQAELLKR 12 1 A0A087WXB0;O15126;A0A087WTX8;A0A087WZA6;O15126-2 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 54718000.0 22162000.0 20189000.0 12367000.0 True False 28689145.878330607 19065464.402442697 10116332.896135781 1.0 0.6645532245295306 0.3526188245212562 24.77400168162312 -7.341885942912061 0.2483102550786291 1.1231598755207628 2.371552856507546e-11 0.9999306986412465 0.00220064140311801 0.11143094873521948 0.017775046235396157 0.017900224470991162 0.051386750898939015 4.55107567604986e-08 7.341885942912061 -1.1231598754970473 down EHALLAYTLGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHALLAYTLGVK 12 0 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 1976750000.0 725831000.0 612602000.0 638317000.0 False True 951571469.9574022 521204169.50389385 572270080.0090219 1.0 0.5477299246132568 0.601394743407597 29.825736776587043 -10.131034589760214 6.670788962377568 1.0000006794286485 0.574562334011515 0.9882072044575145 0.02190857053084344 2.213861170404254e-07 2.8857670493845467e-08 0.021212916021309123 0.007070960733763784 7.395463709011989e-11 10.131034589760214 -0.42543834541713343 EHALLAYTLGVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHALLAYTLGVK 12 0 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 1866593200.0 693282000.0 280294200.0 893017000.0 False True 671274142.393381 392217135.77494276 659109057.7642545 1.0 0.5842875674854985 0.9818776206904786 29.32232682969768 -10.668057615781056 9.635354780824072 1.0001373762830053 0.7830825950923935 0.2841176312149576 0.16231545952636947 0.00047930529376458283 1.651250093933062e-05 0.15725933908007786 0.05238708929813608 2.1475455505883972e-11 10.668057615781056 -0.21705478119061172 EHALLAYTLGVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EHALLAYTLGVK 12 0 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 4623481000.0 856844000.0 2130469000.0 1636168000.0 False True 1299894991.6871874 1750270161.5197287 1312778677.6420908 1.0 1.3464704246979062 1.0099113282513545 30.2757479379392 -10.306027198475626 3.9246572791675782 0.9996653160655757 1.1781908764926234 0.27206815663624295 0.1373996758343214 97593024.6163661 159.7351825577493 296969.1792010928 0.047035563645064365 4.9427973085741746e-11 10.306027198475626 0.1785255604270477 EHALLAYTLGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHALLAYTLGVK 12 0 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 2132266700.0 725831000.0 583547000.0 822888700.0 False True 994190335.5452408 557763964.0081255 628539336.9847556 1.0 0.561023321255917 0.6322122781851905 29.888946838109934 -10.690247655808395 6.749156662233922 1.0032745349684002 0.5966177997205717 0.9771742481228103 0.029062769966281488 0.001439876509395634 6.608299981476435e-05 0.02829501255962067 0.009379968672838766 2.0405739784275345e-11 10.690247655808395 -0.4066567352478285 EHALLAYTLGVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHALLAYTLGVK 12 0 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 1493799000.0 693282000.0 380127000.0 420390000.0 False True 576494700.6001244 378079180.4016983 508291605.3362554 1.0 0.6558242079382902 0.8816934566911537 29.102732105131956 -10.565246300291445 5.0057160886630685 1.0015410316715279 0.7687588323147181 0.5829005386256876 0.09221073467172725 0.001595910864999445 0.00013860710436643442 0.08984931393195844 0.029760886643760573 2.721157627393116e-11 10.565246300291445 -0.23278219935680977 EHALLAYTLGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHALLAYTLGVK 12 0 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 4202923400.0 856844000.0 2145027400.0 1201052000.0 False True 1109201448.9203272 2025654739.559375 982472859.8342094 1.0 1.8262279963041013 0.8857479052074151 30.04687426003165 -6.674711824240637 1.9208925668336545 1.525239898503819 0.8894823709550175 0.29995428788936374 0.3505897516968909 0.4504082249789963 3.2084330058528163 0.14670946827063755 0.38954684002288165 2.114891909199407e-07 6.674711824240637 -0.6357575275488014 EHALLAYTLGVK(ub)QLIVGVNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHALLAYTLGVKQLIVGVNK 20 1 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 33025700.0 19076000.0 4320200.0 9629500.0 True False 18470442.821674474 6045278.389545378 7107245.071192254 1.0 0.32729471880616945 0.3847901828781349 24.13871511899835 -10.787976408151705 10.860922890182536 1.0032068995201806 0.3560424526663578 0.9940567342325545 0.02347242491680639 0.0018200562075093858 3.5530528242894204e-05 0.022694267153636653 0.007575692566491278 1.6293845420508996e-11 10.787976408151705 -0.6471644468538228 EHALLAYTLGVK(ub)QLIVGVNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EHALLAYTLGVKQLIVGVNK 20 1 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 87663200.0 7965200.0 16512000.0 63186000.0 True False 12083790.734120538 13565304.591155173 50697259.40459242 1.0 1.1226034023289844 4.195476446099029 23.526569769157927 -6.915308266254388 0.858809233413533 0.9200744011408463 4.64120326703538 0.9927751723538495 0.12565499785865955 0.10101136652887956 0.12050322390316912 0.1056560090481271 0.3035850065106101 1.215323046836982e-07 6.915308266254388 3.721128865894534 up EHALLAYTLGVK(ub)QLIVGVNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHALLAYTLGVKQLIVGVNK 20 1 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 27436600.0 19076000.0 5886300.0 2474300.0 True False 15862539.210087616 5854589.333560933 2991664.690129397 1.0 0.3690827336040732 0.1885993566671141 23.919120394432625 -13.999999999999996 0.17552069889600452 4.230324009940091 0.0384013315718765 0.999504230720095 0.007745201836053211 12.150045783947505 0.1327608131529264 13.373115636290693 0.14006606614763492 1.0000000000000082e-14 13.999999999999996 -4.191922678368215 EHALLAYTLGVK(ub)QLIVGVNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHALLAYTLGVKQLIVGVNK 20 1 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 61147200.0 7965200.0 36409000.0 16773000.0 True False 10311108.417565139 34382807.14391674 13720486.10551348 1.0 3.334540357013905 1.3306509397321835 23.297696091250376 -6.609016831187788 2.1568996656837953 2.5607737981558643 1.3377128922913952 0.04730432389414774 1.0067573630273894 0.6155492091856791 5.424906444615261 0.38559503073533036 1.118152334115229 2.46027225385315e-07 6.609016831187788 -1.223060905864469 EHALTSGTIK(ub)AMLSGPGQFAENETNEVNFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EHALTSGTIKAMLSGPGQFAENETNEVNFR 30 1 E5RHG8;Q15369;Q15369-2 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 1 74809000.0 29161000.0 24143000.0 21505000.0 True False 44239368.954664 19834493.019880045 17254527.324023653 1.0 0.4483448450678898 0.39002652460314013 25.39882747084044 -13.999999999999998 0.31742160329989594 6.570519623696799 0.3781125222780408 0.9996881763247522 0.004853120004419388 17.815388314389363 0.17956057519043472 65.81362117957077 0.019614156729792376 1.0000000000000041e-14 13.999999999999998 -6.192407101418758 EHALTSGTIK(ub)AMLSGPGQFAENETNEVNFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHALTSGTIKAMLSGPGQFAENETNEVNFR 30 1 E5RHG8;Q15369;Q15369-2 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 1 24178500.0 13033000.0 8526800.0 2618700.0 True False 10837516.959796181 8480864.43596271 3166258.062499234 1.0 0.782546820219436 0.29215714948775323 23.369530915355966 -6.9576305608646685 0.467632114025247 1.0132550866223988 0.041425273128258645 0.999671974161349 0.005361898193936332 0.08055864722412502 0.0243428741554185 0.0067506575734094 0.040481831222324 1.1024767491956409e-07 6.9576305608646685 -0.9718298134941402 down EHALTSGTIK(ub)AMLSGPGQFAENETNEVNFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHALTSGTIKAMLSGPGQFAENETNEVNFR 30 1 E5RHG8;Q15369;Q15369-2 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 1 65743000.0 29161000.0 18716000.0 17866000.0 True False 37749489.34924642 17674438.14731377 14614571.320640566 1.0 0.46820337048258903 0.3871461991295072 25.16995379293289 -13.999999999999998 0.2648394083981806 4.9932286684107865 0.3588654186388169 0.9995723576232654 0.005621072143894606 14.636538307180052 0.16287308697624822 31.37116059770331 0.03455628879504347 1.0000000000000041e-14 13.999999999999998 -4.63436324977197 EHCGAVCFVK(ub)DNPQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHCGAVCFVKDNPQK 15 1 P42768;C9J3B7 P42768 WAS Wiskott-Aldrich syndrome protein 1 18301700.0 2003500.0 2481200.0 13817000.0 True False 2626607.901921597 2111014.6316418513 12387349.382022802 1.0 0.8037037542213502 4.71610146796572 21.324769421423756 -6.895091188030251 0.9917887439551524 0.814713042572573 5.088168100935054 0.9839615282997125 0.22793722470909045 0.11510904156678024 0.19850053408808835 0.17383770111363991 0.4421210651187973 1.2732357139384474e-07 6.895091188030251 4.27345505836248 up EHCGAVCFVK(ub)DNPQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EHCGAVCFVKDNPQK 15 1 P42768;C9J3B7 P42768 WAS Wiskott-Aldrich syndrome protein 1 83283000.0 13345000.0 27356000.0 42582000.0 True False 20245340.650183164 22474108.066596426 34165649.03564638 1.0 1.1100879187425823 1.6875808427228058 24.271086582365214 -6.938741214562233 0.6711763487414171 0.993355188227714 1.837707795628582 0.9979942814781115 0.013504934641313866 0.08834567431717535 0.05726110245505497 0.013023874566129773 0.04998563766925608 1.1514863270381231e-07 6.938741214562233 0.8443526074008681 EHCGAVCFVK(ub)DNPQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHCGAVCFVKDNPQK 15 1 P42768;C9J3B7 P42768 WAS Wiskott-Aldrich syndrome protein 1 21811700.0 2003500.0 2962200.0 16846000.0 True False 2744248.0925516947 2831320.2093145344 12867321.75426057 1.0 1.031728952276278 4.688833268823045 21.387979482946648 -6.908798728958799 0.903860457604995 0.8824217555850293 5.1495320141358665 0.990460671120694 0.16911496695630288 0.10521819750630321 0.1431097374849797 0.13763949382893545 0.3768657696765327 1.23367644033785e-07 6.908798728958799 4.267110258550837 up EHCGAVCFVK(ub)DNPQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHCGAVCFVKDNPQK 15 1 P42768;C9J3B7 P42768 WAS Wiskott-Aldrich syndrome protein 1 70613000.0 13345000.0 24160000.0 33108000.0 True False 17275365.56927724 22815474.76165313 27082683.716767464 1.0 1.3206941798226544 1.5677053899763311 24.042212904457664 -6.974034535075784 0.12954490872954666 0.6148165262031274 2.279973868967727 0.9999992317145131 0.00020363392932586943 0.07501384637958214 0.003887606448497386 0.015619252446513424 0.03382462615795637 1.0616111345770584e-07 6.974034535075784 1.6651573427645996 EHCPAGQPVK(ub)VR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHCPAGQPVKVR 12 1 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 3914900.0 532100.0 1247300.0 2135500.0 True False 697588.252863729 1061207.7019373195 1914538.9451624611 1.0 1.5212522538630278 2.7445114468354705 19.412016220288553 -6.956802873332412 0.47837385781258657 0.9701842380374887 3.3464398701456983 0.9996326074538299 0.014014545923752324 0.08086369622068043 0.02550669074419149 0.017191108577906355 0.10091468480575598 1.1045798759619542e-07 6.956802873332412 2.37625563210821 EHCPAGQPVK(ub)VR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHCPAGQPVKVR 12 1 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 2377990.0 789670.0 912690.0 675630.0 True False 764602.3580935035 1277131.8766154735 498662.2345344633 1.0 1.670321655559546 0.6521850596666375 19.544350124000633 -6.729144305721076 1.726317893356 1.4037966570282068 0.6528919062467121 0.5552027140999671 0.28180933892565885 0.3378999403349301 1.9724074945269947 0.12938258969855582 0.321369570324808 1.8657596402988914e-07 6.729144305721076 -0.7509047507814947 EHCPAGQPVK(ub)VR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHCPAGQPVKVR 12 1 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 3726360.0 532100.0 837660.0 2356600.0 True False 728831.7494618199 800649.411428808 1800019.615700486 1.0 1.098538053563143 2.469732715444473 19.475226281811445 -6.92136896067743 0.8145149443756268 0.9712126373999369 2.697961775726093 0.9945527257799746 0.04951032863703574 0.09737285821170856 0.10149113460679396 0.04297041074596807 0.13044947427560188 1.198480685247661e-07 6.92136896067743 1.7267491383261562 up EHCPAGQPVK(ub)VR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHCPAGQPVKVR 12 1 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 2502120.0 789670.0 678050.0 1034400.0 True False 656645.593312533 674397.2100676122 1250688.257474781 1.0 1.0270337864684798 1.9046625306133915 19.32475539943491 -6.913471294775736 0.8717701315604757 0.9757179377909743 2.0269205090296887 0.9921666498260165 0.03719341176138867 0.10216723487483222 0.12665031957417938 0.03098325075479595 0.0877307223229314 1.2204744868304217e-07 6.913471294775736 1.0512025712387145 EHDQLIEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHDQLIEKR 9 1 O14980 O14980 XPO1 Exportin-1 1 3218400.0 1259400.0 0.0 1959000.0 True False 1651085.5960469495 0.0 1756301.4720549088 1.0 0.0 1.0637252703674893 20.654983484118908 -10.551565321898298 5.048732507146644 1.0025488634487292 0.5318626351837378 0.2052401466871211 0.4342640231507632 0.012515817807936076 0.0011116690523975794 0.4223905889508892 0.14015811079332452 2.808242955342464e-11 10.551565321898298 -0.4706862282649914 EHDQLIEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHDQLIEKR 9 1 O14980 O14980 XPO1 Exportin-1 1 3435640.0 796790.0 770650.0 1868200.0 True False 771496.3375907949 1078374.563886659 1378862.3752013452 1.0 1.3977701660310844 1.7872571884232327 19.55729978255863 -6.971383580932759 0.2226735417831755 0.8263406214653478 2.369719181328402 0.9999912557861461 0.0009503889850456289 0.07585625720320105 0.00740287088130092 0.010571016531824674 0.03925612696020142 1.0681110771576109e-07 6.971383580932759 1.5433785598630543 EHDQLIEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHDQLIEKR 9 1 O14980 O14980 XPO1 Exportin-1 1 3984670.0 1259400.0 788170.0 1937100.0 True False 1725034.214005295 753346.0432703514 1479596.8758267923 1.0 0.4367136820557224 0.8577203071186452 20.7181935456418 -9.79669114588807 6.200108244314053 1.0000000122141288 0.6472169945869031 0.48352877109186787 0.17187523495694293 2.8983121458604755e-08 5.399500501904039e-09 0.1664174868525008 0.055472493550990515 1.5970144808934231e-10 9.79669114588807 -0.35278301762722575 EHDQLIEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHDQLIEKR 9 1 O14980 O14980 XPO1 Exportin-1 1 4726290.0 796790.0 1028700.0 2900800.0 True False 662566.1887820147 1023158.188919037 3507343.8682162063 1.0 1.5442354382735606 5.293575083666287 19.337705057992906 -6.932985897434379 0.7218610218023751 0.9488189807517351 6.125292374589223 0.9970932508908246 0.10290665744257325 0.09111678685444494 0.07030010238836672 0.09547713928179455 0.33385545082045964 1.1668475067350136e-07 6.932985897434379 5.176473393837488 up EHEK(ub)EVLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHEKEVLQK 9 1 P16949;P16949-2;A2A2D0 P16949 STMN1 Stathmin 1 5076640.0 3412410.0 1066600.0 597630.0 True False 4473702.555825445 907467.4375742375 535792.9804717585 1.0 0.20284483070797277 0.11976499863051336 22.0930379080858 -13.999999999999998 0.3194844339286697 9.148570648543645 0.10317606245234281 0.9996926204767028 0.006957086235294559 17.973451340705346 0.18023433503244665 97.86648943042364 0.027716187128745122 1.0000000000000041e-14 13.999999999999998 -9.045394586091302 EHEK(ub)EVLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHEKEVLQK 9 1 P16949;P16949-2;A2A2D0 P16949 STMN1 Stathmin 1 9342390.0 3748970.0 5005600.0 587820.0 True False 3629960.999432428 7004362.183859165 433852.30777799786 1.0 1.929597090699969 0.11951982620359668 21.791522617206994 -6.767120318769282 1.5855149702747398 1.5351618540252108 0.110446485807429 0.7193798707714878 0.3915021835463748 0.2711291790567813 1.3446746538470014 0.19468448959997484 0.46465778475325065 1.7095416308763013e-07 6.767120318769282 -1.4247153682177818 EHEK(ub)EVLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHEKEVLQK 9 1 P16949;P16949-2;A2A2D0 P16949 STMN1 Stathmin 1 5094930.0 3412410.0 1035000.0 647520.0 True False 4674070.193912817 989270.2777126943 494589.11209300696 1.0 0.21165071055224005 0.10581550802063805 22.156247969608692 -13.999999999999998 0.28299253982792544 7.53214762297858 0.07488317197351238 0.9996118181677074 0.007859725974417645 15.562504079518705 0.16856494131117866 58.9387916047801 0.04127949761843934 1.0000000000000041e-14 13.999999999999998 -7.457264451005067 EHEK(ub)EVLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHEKEVLQK 9 1 P16949;P16949-2;A2A2D0 P16949 STMN1 Stathmin 1 8280800.0 3748970.0 4100400.0 431430.0 True False 3117434.6625310443 4078310.331334324 521640.01829306316 1.0 1.308226401775858 0.1673298961363135 21.57192789264127 -6.8347441429022515 1.3064619483759052 1.1642299273303636 0.1335107388259695 0.9150769062515095 0.14043117496404348 0.17500738602822663 0.5824808960857144 0.08435110815725637 0.1941517800541115 1.4630388446948714e-07 6.8347441429022515 -1.030719188504394 down EHELLEQQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHELLEQQK 9 0 Q13435;E9PJ04;H0YCG1;E9PJT3 Q13435 SF3B2 Splicing factor 3B subunit 2 0 3179890.0 864290.0 473800.0 1841800.0 False True 836853.5870384278 662990.8108343593 1359377.327184368 1.0 0.7922423003295499 1.6243908710424708 19.674615710437678 -6.840600591996254 1.279648036511941 0.889487295040463 1.6520802764095623 0.9254759478603021 0.09653825150770311 0.16809766156697434 0.534442343696282 0.05915070120095728 0.13629095156896345 1.4434422331240722e-07 6.840600591996254 0.7625929813690994 EHELLEQQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHELLEQQKR 10 1 Q13435;E9PJ04;H0YCG1;E9PJT3 Q13435 SF3B2 Splicing factor 3B subunit 2 1 5021300.0 1783500.0 1601300.0 1636500.0 True False 1726883.7687385408 2240707.4406691836 1207851.5560523504 1.0 1.29754386556426 0.6994399842756444 20.719739552070802 -6.771414253968592 1.5688300839485205 1.1703503779804114 0.6958764198531112 0.7360422496203831 0.1254498207349136 0.2641340502764342 1.2831431314893555 0.06301965787894602 0.14983202845991064 1.6927224183856228e-07 6.771414253968592 -0.4744739581273002 EHEVTIFVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHEVTIFVR 9 0 P53396;P53396-2;P53396-3;K7EIE7 P53396 ACLY ATP-citrate synthase 0 61005000.0 21479000.0 23655000.0 15871000.0 False True 28159177.002931897 20125766.20646783 14228821.165382057 1.0 0.7147142902781698 0.5052996102798235 24.747101833728667 -7.518087967206205 0.13876569814561282 1.3286095983861184 2.304706948788774e-12 0.9999889188691208 0.0006748988557047895 0.13255910084531194 0.012628421626719412 0.04312586466227982 0.07002833475326385 3.0332767257668296e-08 7.518087967206205 -1.3286095983838138 EHEVTIFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHEVTIFVR 9 0 P53396;P53396-2;P53396-3;K7EIE7 P53396 ACLY ATP-citrate synthase 0 40660900.0 9354900.0 10603000.0 20703000.0 False True 9057933.820113376 14836833.193914544 15280263.223313056 1.0 1.6379931106329098 1.6869479868999304 23.1107505680031 -11.375417758305758 0.43250655991716747 5.972180423294035e-09 1.6882828422791887 0.9997157236528343 0.0052761600249777805 3.6774381411721677 0.21408704600293893 3.493978454871817 0.011499857256105344 4.212910584561638e-12 11.375417758305758 1.6882828363070082 EHEVTIFVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EHEVTIFVR 9 0 P53396;P53396-2;P53396-3;K7EIE7 P53396 ACLY ATP-citrate synthase 0 97645000.0 19475000.0 51632000.0 26538000.0 False True 29544998.813212156 42417866.19734268 21292752.66798138 1.0 1.4357037705607874 0.7206888990789034 24.816410605172276 -6.741782569770294 1.6802644828444488 1.2587046259272885 0.7201117225093465 0.612896241168307 0.18305798958137606 0.3145915558777597 1.7446372199066105 0.08616534821472463 0.21102196832119782 1.8122471699913437e-07 6.741782569770294 -0.538592903417942 EHEVTIFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHEVTIFVR 9 0 P53396;P53396-2;P53396-3;K7EIE7 P53396 ACLY ATP-citrate synthase 0 70918000.0 21479000.0 22277000.0 27162000.0 False True 29420366.7481497 21292728.479812235 20746895.0189496 1.0 0.7237410961626225 0.7051881846528787 24.81031189525156 -13.999999999999998 0.3837073349287794 5.196337117389974 0.7036629052052984 0.9998134251467464 0.0018414695805384026 24.51053536539372 0.202385595320215 85.09120264009078 0.004973435837268585 1.0000000000000041e-14 13.999999999999998 -4.492674212184675 EHEVTIFVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHEVTIFVR 9 0 P53396;P53396-2;P53396-3;K7EIE7 P53396 ACLY ATP-citrate synthase 0 23381900.0 9354900.0 6597600.0 7429400.0 False True 7779013.842338478 6562057.419278932 8982853.190335585 1.0 0.8435590361806437 1.1547547507172473 22.891155843437375 -6.770026242776116 1.5742952919260509 0.9102721380879003 1.1565089465993303 0.7306712460165841 0.06593279208400943 0.2663929368427126 1.3029788770652913 0.033011044313018524 0.07857994189725297 1.6981410371089137e-07 6.770026242776116 0.24623680851143004 EHEVTIFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHEVTIFVR 9 0 P53396;P53396-2;P53396-3;K7EIE7 P53396 ACLY ATP-citrate synthase 0 80267000.0 19475000.0 39852000.0 20940000.0 False True 25210771.409642078 37634201.16727657 17129134.862544116 1.0 1.4927826108836575 0.6794371574045898 24.587536927264726 -6.742716054620356 1.6770862594269917 1.2922807751818532 0.6787033107043438 0.6169511288580365 0.20703690005432493 0.31291467496630493 1.7291636580222651 0.09762827161671524 0.2388295337214182 1.8083560579682884e-07 6.742716054620356 -0.6135774644775095 EHFAQFGHVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHFAQFGHVR 10 0 Q9GZT3-2;Q9GZT3;H0YJW7;A0A087WUN7;H0YJ40;G3V4X6;G3V2S9;H0YJ07;H0YJU7 Q9GZT3-2 SLIRP SRA stem-loop-interacting RNA-binding protein, mitochondrial 0 10544200.0 3059300.0 3261800.0 4223100.0 False True 4010771.9263033476 2775152.1543968143 3786134.1228356725 1.0 0.6919246981352588 0.9439913793166694 21.935448498541557 -9.975186524072592 6.3235506228516885 1.0000000602158814 0.8179580395758584 0.41017770172360923 0.1029057916752345 8.73701200212347e-08 1.4087570507584479e-08 0.09963813701045439 0.03321270144886922 1.0587988865718062e-10 9.975186524072592 -0.18204202064002295 EHFAQFGHVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHFAQFGHVR 10 0 Q9GZT3-2;Q9GZT3;H0YJW7;A0A087WUN7;H0YJ40;G3V4X6;G3V2S9;H0YJ07;H0YJU7 Q9GZT3-2 SLIRP SRA stem-loop-interacting RNA-binding protein, mitochondrial 0 9831820.0 2345200.0 947320.0 6539300.0 False True 2270752.909697575 1325589.8162085363 4826461.155205095 1.0 0.583766648739022 2.125489362842167 21.1147392981131 -6.8348087870397345 1.3061971501640512 0.778218299929617 2.171230633882292 0.9151711823068015 0.18967278212486585 0.174948858569814 0.5820293986066712 0.1139490187282058 0.2622751690866063 1.4628210895778032e-07 6.8348087870397345 1.393012333952675 up EHFAQFGHVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHFAQFGHVR 10 0 Q9GZT3-2;Q9GZT3;H0YJW7;A0A087WUN7;H0YJ40;G3V4X6;G3V2S9;H0YJ07;H0YJU7 Q9GZT3-2 SLIRP SRA stem-loop-interacting RNA-binding protein, mitochondrial 0 10166700.0 3059300.0 2375400.0 4732000.0 False True 4190405.8844738784 2270446.9736026404 3614399.058599131 1.0 0.5418203000370462 0.8625415194244204 21.99865856006445 -10.168315681098958 5.641551600185592 1.0000060528865302 0.7021809097307137 0.534821035108193 0.13093388953045224 9.968378278798612e-06 1.4694118059529316e-06 0.12677876938967877 0.04225873113378992 6.787101107077757e-11 10.168315681098958 -0.29782514315581654 EHFEK(ub)WGTLTDCVVMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHFEKWGTLTDCVVMR 16 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 26842200.0 9444900.0 9744400.0 7652900.0 True False 12382355.364541695 8290573.503373709 6861051.319800419 1.0 0.6695473727974828 0.5540990480250496 23.56178243349179 -13.999999999999995 0.14662412629870092 2.5901561301453655 0.42201748333718275 0.9995778950406845 0.0038822273505348145 11.94662280789749 0.1204103001234503 5.418488470901658 0.1186827771366962 1.0000000000000123e-14 13.999999999999995 -2.168138646808183 EHFEK(ub)WGTLTDCVVMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 EHFEKWGTLTDCVVMR 16 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 41005100.0 17477400.0 13437700.0 10090000.0 True False 16922589.50364506 18803443.68667974 7447126.306488372 1.0 1.1111445847356607 0.4400701384905833 24.012447011524042 -6.864366490563877 1.16356516743781 1.0611497385330886 0.4047702652862579 0.9587253406525114 0.05966390055783811 0.1423661507183771 0.3638234256610616 0.03991828808072982 0.09368279061022329 1.3665751193240988e-07 6.864366490563877 -0.6563794732468307 down EHFEK(ub)WGTLTDCVVMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 EHFEKWGTLTDCVVMR 16 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 154434900.0 28489900.0 70030000.0 55915000.0 True False 43221261.190682136 57532599.35311263 44863375.74158487 1.0 1.3311180138703544 1.0379932122678721 25.365237834673554 -10.580663596532995 6.600387147379634 0.9996849752708334 1.184555613069113 0.3457862854134506 0.11966769914677243 0.0005556783934664169 3.530341335838927e-05 0.11606287899418753 0.03862258382286746 2.6262520442627376e-11 10.580663596532995 0.1848706377982796 EHFEK(ub)WGTLTDCVVMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EHFEKWGTLTDCVVMR 16 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 37992900.0 12417700.0 15782100.0 9793100.0 True False 17008859.265724596 15084794.637574421 7480171.475225519 1.0 0.886878679040666 0.43978090231478295 24.01978305113476 -6.945150236299839 0.6097727537977428 1.0049470224638708 0.29843832763658057 0.998763587325577 0.008505020209887592 0.08549369472740682 0.044487093335945915 0.008647017702235513 0.0376973941122845 1.1346182471695861e-07 6.945150236299839 -0.7065086948272903 down EHFEK(ub)WGTLTDCVVMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 EHFEKWGTLTDCVVMR 16 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 120143600.0 28489900.0 50983600.0 40670100.0 True False 36880737.16988771 48146317.84181365 33268559.110465884 1.0 1.305459747727712 0.9020578671520947 25.136364156766003 -6.704227323391651 1.8160615967566534 1.1888893593705727 0.9031683731779132 0.4375620976935415 0.1288414896467525 0.38678048319874875 2.4828930405875678 0.05654066883377074 0.144639326048059 1.975935102799095e-07 6.704227323391651 -0.2857209861926595 EHFQDDVFNEK(ub)GWNYILEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHFQDDVFNEKGWNYILEK 19 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 21634600.0 10023000.0 5733800.0 5877800.0 True False 9704825.351312812 8023336.241371987 4338227.849779715 1.0 0.8267367985438951 0.44701761162480524 23.210270819660117 -6.958217406874054 0.45987203676300875 1.0110822940329693 0.24736829690711465 0.9996982516150728 0.004011619433941932 0.08034421316710486 0.023531801995104153 0.005155893608876614 0.031369041521523935 1.1009880193552084e-07 6.958217406874054 -0.7637139971258546 down EHFQDDVFNEK(ub)GWNYILEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EHFQDDVFNEKGWNYILEK 19 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 108191000.0 10453000.0 16467000.0 81271000.0 True False 15857965.216662733 13528335.19274175 65207751.22765524 1.0 0.8530940135072861 4.111987278111715 23.918704330577643 -6.896344567237182 0.9840947777320942 0.8505859440615571 4.429757589954587 0.9846580519166754 0.18614422618180604 0.11414600484724141 0.19298549682654387 0.14278479027260613 0.3651333027459737 1.26956643737097e-07 6.896344567237182 3.57917164589303 up EHFQDDVFNEK(ub)GWNYILEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHFQDDVFNEKGWNYILEK 19 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 8748800.0 1899300.0 3035300.0 3814200.0 True False 2601522.5366525743 2901190.409605159 2913364.515914791 1.0 1.1151894203223673 1.119869028566429 21.310924774573078 -12.95664636369653 0.4692350372632427 0.008130211157129153 1.1197696713272607 0.9999011586957403 0.0005511160489847088 14.45749343885361 0.23560546749964534 14.451627162202469 0.001013166200746829 1.1049780126080188e-13 12.95664636369653 1.1116394601701316 EHFQDDVFNEK(ub)GWNYILEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHFQDDVFNEKGWNYILEK 19 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 24739800.0 10023000.0 5499100.0 9217700.0 True False 8334568.594186839 5469475.2568141185 11145078.45217061 1.0 0.6562397555440297 1.3372111977030263 22.990676095094393 -6.76946829316311 1.576553228608531 0.8026946122529783 1.340959054581246 0.7285057400333887 0.1448572694386799 0.2672870080121868 1.3110429129493806 0.07242843838205316 0.17248946608695398 1.7003240858447075e-07 6.76946829316311 0.5382644423282676 EHFQDDVFNEK(ub)GWNYILEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHFQDDVFNEKGWNYILEK 19 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 88961000.0 10453000.0 11804000.0 66704000.0 True False 13531614.559434593 11147097.023450067 54564556.440837815 1.0 0.8237817427099283 4.032375900242739 23.689830652670093 -6.893913818702893 0.9989697311762938 0.8434229409682876 4.3304415620414485 0.9832865085791052 0.1904005432153209 0.11602401362334051 0.20377069668991182 0.1444301861161487 0.36551877999898724 1.276692130168684e-07 6.893913818702893 3.487018621073161 up EHFQSYDLDHMEK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHFQSYDLDHMEKK 14 1 Q13564;Q13564-4;Q13564-3;Q13564-2;H3BMR3;J3QRA5 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 1 13562800.0 1112900.0 1600900.0 10849000.0 True False 1440670.9885386752 1511808.507695799 8874593.320140457 1.0 1.0493780465651503 6.160041668599351 20.458309468750898 -6.909014700639754 0.9024243085476344 0.8367908575836818 6.806763686299096 0.9905442680873346 0.23541094297228918 0.10507301369081438 0.1423303905398055 0.19180007194141133 0.5259054830222494 1.233063093985402e-07 6.909014700639754 5.969972828715414 up EHGAFDAVK(ub)CTHWAEGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHGAFDAVKCTHWAEGGK 18 1 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 1 14926500.0 4619100.0 5565100.0 4742300.0 True False 6055684.831428031 4734808.772589897 4251612.28735375 1.0 0.7818783348857589 0.7020861233214393 22.529858691429876 -13.999999999999998 0.13982442364745742 2.0417689887086823 0.6031298959515097 0.9996036328842713 0.0025068775268833913 11.933850510734898 0.11714345972593021 3.3924235809302172 0.08845538505657358 1.0000000000000041e-14 13.999999999999998 -1.4386390927571726 EHGAFDAVK(ub)CTHWAEGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EHGAFDAVKCTHWAEGGK 18 1 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 1 32460400.0 10587000.0 9222400.0 12651000.0 True False 16061253.013374973 7576590.665059922 10150524.304869713 1.0 0.47173098255475665 0.6319883197417341 23.937081112836765 -10.881904309559546 11.154058230679205 1.0215857845716438 0.5518596511482704 0.9124827470537035 0.06542478394087439 0.028159386663120387 0.00029814226007330295 0.050793242099056266 0.021115758219352077 1.3124890549393303e-11 10.881904309559546 -0.46972613342337344 EHGAFDAVK(ub)CTHWAEGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHGAFDAVKCTHWAEGGK 18 1 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 1 12961900.0 4619100.0 4295200.0 4047600.0 True False 6326906.096483925 4105423.8616730087 3091640.2429386843 1.0 0.6488833244979771 0.48864961733141776 22.593068752952767 -13.999999999999998 0.10554302304163653 2.7093150203343073 0.1749061048894138 0.9997657187519038 0.0032686624301505886 12.040685750850027 0.09782454083742302 4.425000256563829 0.27906863361883544 1.0000000000000041e-14 13.999999999999998 -2.5344089154448937 EHGAFDAVK(ub)CTHWAEGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHGAFDAVKCTHWAEGGK 18 1 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 1 12107000.0 5149100.0 3281100.0 3676800.0 True False 4281704.793806993 3263424.063052646 4445601.8803975945 1.0 0.7621786695273395 1.0382784648833474 22.029753900500157 -6.678842302596432 1.9065204706700967 0.8493649999192256 1.0372045123848876 0.31858226569377235 0.10082105048489416 0.4411129467790837 3.099085776017517 0.042454005658260276 0.11211458616037258 2.094872990636348e-07 6.678842302596432 0.187839512465662 EHGAFDAVK(ub)CTHWAEGGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHGAFDAVKCTHWAEGGK 18 1 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 1 27261600.0 10587000.0 7811800.0 8862800.0 True False 13705080.200969504 7377066.462875905 7249861.340007447 1.0 0.5382724037145035 0.5289908000315524 23.708207434929214 EHIAASVSIPSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHIAASVSIPSEK 13 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 0 9582500.0 2734100.0 4826300.0 2022100.0 False True 3584431.577062065 4106234.8527700515 1812872.489352852 1.0 1.145574902042258 0.5057628944444102 21.77331292228948 -6.846891970353622 1.2499859146572099 1.077524247223481 0.4816773445839126 0.9356619314499892 0.06945560472808734 0.16090809223902208 0.48537000780436595 0.04351228427148261 0.10051085094260642 1.4226826317936017e-07 6.846891970353622 -0.5958469026395683 EHIAASVSIPSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EHIAASVSIPSEK 13 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 0 20953000.0 3398200.0 10515000.0 7039800.0 False True 5155317.841697442 8638516.095930027 5648380.444346045 1.0 1.6756515041729618 1.0956415526236996 22.297629946385047 -10.29848857827045 4.960635906352926 0.9998722835969313 1.3856465283985109 0.3708514055237516 0.23678807117263845 0.0003345711132113873 4.731371669430079e-05 0.22934449778068033 0.07642302135259457 5.029344926043167e-11 10.29848857827045 0.3857742448015796 EHIAASVSIPSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHIAASVSIPSEK 13 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 0 8741400.0 2734100.0 2518200.0 3489100.0 False True 3744970.656274318 2406937.5974261914 2665046.4402701226 1.0 0.642712004536968 0.711633463884452 21.836522983812372 -10.780807969888237 7.066541312435989 1.0091209625321276 0.67717273421071 0.9669454117052468 0.028137067954885 0.00406795253007622 0.00012618078465800121 0.027410191481183337 0.009081199633364664 1.6565022499933997e-11 10.780807969888237 -0.33194822832141757 EHIAASVSIPSEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHIAASVSIPSEK 13 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 0 10790600.0 3398200.0 5490500.0 1901900.0 False True 4399036.888536371 5184948.848462609 1555773.715141962 1.0 1.1786554602381891 0.3536623480462771 22.068756268477497 -6.85000258469071 1.2349611436470027 1.0953453363768502 0.3206608192356984 0.9403174059782764 0.08657576452685752 0.15746180445571567 0.4621090806902059 0.05485355085307567 0.12694361059669795 1.4125291379725274e-07 6.85000258469071 -0.7746845171411518 down EHIAASVSIPSEK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHIAASVSIPSEKQR 15 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 175792560.0 81480560.0 68980000.0 25332000.0 True False 106821803.2188655 58688452.88193402 22710887.641702365 1.0 0.5494051880184814 0.21260535730866092 26.67063090224197 -8.037972721750252 0.29623239115792493 1.1315285234093373 1.3249144665711637e-19 0.9991933687381281 0.009161378594308546 0.09582283996284172 0.05876750636415396 0.06295355579310945 0.09161465154903045 9.16278040188416e-09 8.037972721750252 -1.1315285234093373 down EHIAASVSIPSEK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHIAASVSIPSEKQR 15 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 259109300.0 88807900.0 102692400.0 67609000.0 True False 85988741.82548682 143698010.85379145 49900174.67347592 1.0 1.6711258683773387 0.5803105571046471 26.357644449889623 -6.740268573537775 1.6859892221288186 1.399197296796092 0.5796671288632882 0.6060443617995226 0.2819755186018057 0.31732303904086634 1.7712565442061512 0.13231079922685451 0.32454848073774206 1.818575879057611e-07 6.740268573537775 -0.8195301679328038 EHIAASVSIPSEK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EHIAASVSIPSEKQR 15 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 484235900.0 269425900.0 132910000.0 81900000.0 True False 408738787.971688 109191172.06943016 65712429.10195482 1.0 0.2671416936260854 0.16076876243638152 28.60660391598608 -13.999999999999998 0.27182012496020125 6.71215443373624 0.1260779142219165 0.9995872547707626 0.007579562776001047 14.973008988456655 0.16505880759022726 47.31451050587856 0.043780612617312885 1.0000000000000041e-14 13.999999999999998 -6.586076519514323 EHIAASVSIPSEK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHIAASVSIPSEKQR 15 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 177412060.0 81480560.0 59227500.0 36704000.0 True False 111606124.96133973 56610633.21084893 28035271.14260828 1.0 0.5072358997363164 0.25119832045346685 26.733840963764862 -9.316891008089613 0.2001453862082189 1.4597086177018135 7.165797912977404e-21 0.9995196740243627 0.0068104438786768 0.7404880939369431 0.07441089460461661 0.35327776452132514 0.14200850380266344 4.820687639400552e-10 9.316891008089613 -1.4597086177018135 EHIAASVSIPSEK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHIAASVSIPSEKQR 15 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 254858700.0 88807900.0 138026800.0 28024000.0 True False 73847703.70704244 137283222.23222527 33883688.83166398 1.0 1.8590046181643607 0.4588319897675123 26.1380497253239 -6.740737068272583 1.6842534711135384 1.5106883324761102 0.4579286392304391 0.6080821015574802 0.36091220679152664 0.3165137950708773 1.763277363680228 0.16951044035606955 0.41558619257342727 1.8166151499176977e-07 6.740737068272583 -1.052759693245671 EHIAASVSIPSEK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHIAASVSIPSEKQR 15 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 471682900.0 269425900.0 145960000.0 56297000.0 True False 348777138.728477 137837197.69084808 46051523.65600032 1.0 0.3952013546339525 0.13203710490856294 28.37773023807853 -9.352663140044196 0.2712586473531525 1.3566456284489896 1.6884175724832926e-25 0.9988971874001306 0.012067303095783508 0.7603314068046956 0.10496519705097962 0.3468707425504093 0.10142828354163241 4.4395286188387094e-10 9.352663140044196 -1.3566456284489896 EHIK(ub)NPDWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EHIKNPDWR 9 1 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 1 10873700.0 2094900.0 3740900.0 5037900.0 True False 3178116.45770466 3073307.1672148965 4042156.8568099844 1.0 0.9670215702021631 1.2718718494442343 21.59974056055392 -6.880106371581568 1.0791538506276879 0.9795292836406944 1.2935250068670647 0.9737733616590076 0.022121847476804603 0.12753829494087116 0.27168854685846566 0.015788948693723666 0.03819371146032119 1.317933897975183e-07 6.880106371581568 0.31399572322637037 EHIK(ub)NPDWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHIKNPDWR 9 1 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 1 10295700.0 2094900.0 2758700.0 5442100.0 True False 2711889.3466525944 2605175.919907803 4451693.64066148 1.0 0.9606497857751783 1.6415469333792705 21.370866882646368 -6.893196000518314 1.0033042650563735 0.9661678353904781 1.7039085943884118 0.9828655639533127 0.04085563732543931 0.11658780307207045 0.20701660107838415 0.030890329985118984 0.07794961381242906 1.27880403957589e-07 6.893196000518314 0.7377407589979337 EHK(ub)AVIIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHKAVIIQK 9 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 6241710.0 2013470.0 1294700.0 2933540.0 True False 2639678.6684712186 1101535.806701073 2630005.4213026855 1.0 0.4172992038228017 0.996335445187298 21.331930888446458 -10.070954807825673 11.183303845866533 1.0000030149608718 0.70681732450505 0.2547463464971568 0.2363905556600852 0.0 3.0497603693588644e-10 0.22888417131516103 0.07629472377172032 8.492688443581175e-11 10.070954807825673 -0.2931856904558219 EHK(ub)AVIIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHKAVIIQK 9 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 7520010.0 2060830.0 2941790.0 2517390.0 True False 1995410.079691309 4116462.0882321876 1858010.0389188074 1.0 2.0629654676641738 0.9311419531398992 20.92825383664423 -6.6603428715004975 1.9720060472565035 1.684032826482418 0.9358885793280848 0.23697063596298595 0.45255087447169356 0.4836013560280945 3.6157146545976397 0.18539906752570498 0.5015897263733503 2.1860350878938847e-07 6.6603428715004975 -0.7481442471543333 EHK(ub)AVIIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHKAVIIQK 9 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 5452020.0 2013470.0 2581980.0 856570.0 True False 2757904.270980818 2467899.5861339318 654265.8076129033 1.0 0.8948459930613366 0.23723296508048153 21.39514094996935 -6.934964769327753 0.7048515995883966 1.0084001007229675 0.08340989862705632 0.997427141857965 0.01712054502468923 0.09014072633278811 0.0656443473693953 0.016087113072897168 0.05796468062837094 1.1615428362559793e-07 6.934964769327753 -0.9249902020959112 down EHK(ub)AVIIQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHKAVIIQK 9 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 6389610.0 2060830.0 3046200.0 1282580.0 True False 1713671.4552487347 3029789.515976638 1550761.5480201123 1.0 1.7680107273169654 0.9049351573607344 20.708659112078507 -6.671936010182371 1.9301719543394447 1.489383252002105 0.9083641760130028 0.28783584923513394 0.32608621518322123 0.45666326947725905 3.2817263270675503 0.1359076531013693 0.3622416535062198 2.128452633348127e-07 6.671936010182371 -0.5810190759891023 EHLLLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHLLLAR 7 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 11665730.0 851030.0 5241000.0 5573700.0 False True 1115708.5713862428 4459063.229257987 4996986.990705691 1.0 3.996620034672407 4.478756477148013 20.08952880659709 -9.836655709241219 0.4634705042145796 5.820559777805948e-20 4.488687667741375 0.9988811760258874 0.05147441632944604 1.1329006084267688 0.2059345529279411 1.798882784803358 0.10483411330037641 1.456613366005256e-10 9.836655709241219 4.488687667741375 EHLLLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHLLLAR 7 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 7946860.0 2165500.0 914660.0 4866700.0 False True 2096757.3878347701 1279888.5078888866 3591965.2721295306 1.0 0.6104132577830436 1.7131048603762384 20.99972850867156 -6.811214316093611 1.4094361814675676 0.7879830260489942 1.7329345273372923 0.8629741092945478 0.16901394452402807 0.20514742743042516 0.8029714172532291 0.0942848135624391 0.21798123555556964 1.5444920738888814e-07 6.811214316093611 0.9449515012882981 EHLLLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHLLLAR 7 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 9814330.0 851030.0 4230000.0 4733300.0 False True 1165678.7892209978 4043104.613260574 3615392.0253734705 1.0 3.4684551616166135 3.1015336804657583 20.152738868119982 -10.114474354358704 6.1536117392550995 0.9999918775531855 3.2849944210412114 0.9810277626270079 0.149795067414396 1.6693077212885365e-05 2.402328403890683e-06 0.1450389670987692 0.04834615011998445 7.682908228896154e-11 10.114474354358704 2.2850025434880257 EHMGDILYK(ub)LSSMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 EHMGDILYKLSSMK 14 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 16800800.0 4331200.0 5600900.0 6868700.0 True False 5678245.143400459 4765267.552137209 6157992.813222841 1.0 0.8392148334200826 1.0844887210232494 22.43701370432056 -6.729852822239639 1.723779911032912 0.9032248968986964 1.0843387174524963 0.5585933492095099 0.06759093124144756 0.33650626300371045 1.9588346828537546 0.03107407466626424 0.07712067642174514 1.8627182850395366e-07 6.729852822239639 0.18111382055379988 EHMGDILYK(ub)LSSMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 EHMGDILYKLSSMK 14 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 30255700.0 8419500.0 7573300.0 14262900.0 True False 8152227.581101292 10597358.184237756 10527018.61217176 1.0 1.2999340461010718 1.2913057820632696 22.958762896287087 -10.004983983897825 4.6995587372256225 0.999993928473626 1.2956199140954152 0.9993614946592209 0.003522474089932443 2428879.619640884 0.1914769846663139 163.78982297319635 0.0012058365662579301 9.88589551623299e-11 10.004983983897825 0.2956259856217892 EHMGDILYK(ub)LSSMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 EHMGDILYKLSSMK 14 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 87143500.0 9279700.0 22252800.0 55611000.0 True False 14077983.336943023 18281613.978080016 44619461.47483279 1.0 1.2985960801719343 3.1694498002241365 23.746937347748638 -6.934926434986377 0.7051911845985281 0.9760730997906911 3.6065992783699565 0.9974208414275809 0.04875801348609331 0.09015941842604072 0.06573422310314206 0.045803351469652386 0.16493645146002164 1.1616453679405336e-07 6.934926434986377 2.6305261785792653 up EHMGDILYK(ub)LSSMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHMGDILYKLSSMK 14 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 17110700.0 3199700.0 3798000.0 10113000.0 True False 4382715.558641212 3630191.8016935345 7724517.683772831 1.0 0.8282973770761922 1.7624957815349735 22.063393619290128 -6.859268150462991 1.1894378976128286 0.9070171305505956 1.8071036645792449 0.9527433086062097 0.08826123958143768 0.147558189629938 0.39710153590937153 0.057892811802832324 0.13502885149811078 1.3827123744473922e-07 6.859268150462991 0.9000865340286492 EHMGDILYK(ub)LSSMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHMGDILYKLSSMK 14 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 21617500.0 6181500.0 6408800.0 9027200.0 True False 5140191.136881764 6374274.522352798 10914745.782943092 1.0 1.2400851160215174 2.123412435897159 22.293390576039922 -6.946796893812805 0.5929670892924345 0.9898762950069193 2.4182962322957318 0.9989253487009222 0.015835011220102266 0.08479801060652518 0.04148599922095195 0.016366948812601267 0.07406748957030372 1.1303244090842184e-07 6.946796893812805 1.4284199372888124 up EHMGDILYK(ub)LSSMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHMGDILYKLSSMK 14 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 48545100.0 7080100.0 10452000.0 31013000.0 True False 9165329.019635802 9870337.011953587 25368952.220252164 1.0 1.0769211875326434 2.7679259703499697 23.12775524130339 -6.916411173465344 0.8509106900597693 0.9576487598332033 3.019317238365382 0.9931247208327919 0.06765076506072482 0.1003298486917731 0.11689365662117483 0.05720626436693796 0.16589956800346115 1.2122406037851256e-07 6.916411173465344 2.061668478532179 up EHMQPTHPIR ddPTM_RPMI8226_Bortezomib_1h_R1 2 EHMQPTHPIR 10 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 32831630.0 920130.0 19544200.0 12367300.0 False True 1206299.3405515945 16628281.542694926 11087650.431518478 1.0 13.78454002560546 9.191458586430562 20.202156522617468 -9.637850586283351 8.255186766464783 0.9999943945407308 11.487999306018047 0.874246986969819 1.875117645507374 0.0 4.4782181983685435e-18 1.815574853306111 0.6051916177687038 2.3022337365977312e-10 9.637850586283351 10.488004911477315 EHMQPTHPIR ddPTM_RPMI8226_Bortezomib_2h_R1 2 EHMQPTHPIR 10 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 23663950.0 6233500.0 2909550.0 14520900.0 False True 6035620.954545393 4071348.4881028053 10717440.672337657 1.0 0.6745533754959704 1.7756981018276854 22.525070774763215 -6.827535949604835 1.3388129142160416 0.8257800815636528 1.8038789801226764 0.9008639388817464 0.14543245458999737 0.18387606102604856 0.6454293275600526 0.08530935180031146 0.1963587656142927 1.4875242361533948e-07 6.827535949604835 0.9780988985590237 EHMQPTHPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EHMQPTHPIR 10 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 29546930.0 920130.0 15932200.0 12694600.0 False True 1260326.9265782838 15228262.723260099 9696396.93349378 1.0 12.082787729215601 7.693556908935484 20.26536658414036 -9.129854108185501 10.51459916447606 1.000000000520163 9.888172319076928 0.8453801589431699 1.791895978835441 0.0 0.0 1.7349958210392677 0.5783319403464224 7.41559310235153e-10 9.129854108185501 8.888172318556764 EHNFTRPNEK(ub)GEYEVAEGIGSTVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHNFTRPNEKGEYEVAEGIGSTVFR 25 2 B7Z503;Q9BSF8;Q9BSF8-2 B7Z503 BTBD10 BTB/POZ domain-containing protein 10 1 14037100.0 2778900.0 5324600.0 5933600.0 True False 3643164.810905878 4530190.435128234 5319647.991110264 1.0 1.243476666651761 1.4601722038996985 21.79676083108022 -6.972502215931689 0.18909982452767995 0.8513970199091435 1.8581660953785692 0.9999958901844406 0.0003810229132899348 0.0754988311667921 0.006026274592272771 0.007709356940848925 0.02368142219802519 1.065363427773945e-07 6.972502215931689 1.0067690754694256 EHNFTRPNEK(ub)GEYEVAEGIGSTVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHNFTRPNEKGEYEVAEGIGSTVFR 25 2 B7Z503;Q9BSF8;Q9BSF8-2 B7Z503 BTBD10 BTB/POZ domain-containing protein 10 1 24112500.0 4584300.0 7295200.0 12233000.0 True False 4438773.9058189485 10208211.403965421 9028810.317866428 1.0 2.299781791224624 2.03407754245609 22.08172979448618 -10.12697020326161 4.637763589819366 0.9998969770043346 2.1669296667922042 0.9625715433336819 0.10847330539621504 0.00011695254863242904 2.2015292464799762e-05 0.10503807483388802 0.0350096087660814 7.464999736621997e-11 10.12697020326161 1.1670326897878698 EHNFTRPNEK(ub)GEYEVAEGIGSTVFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EHNFTRPNEKGEYEVAEGIGSTVFR 25 2 B7Z503;Q9BSF8;Q9BSF8-2 B7Z503 BTBD10 BTB/POZ domain-containing protein 10 1 96162000.0 13556000.0 62780000.0 19826000.0 True False 20565443.076349415 51576418.49762122 15907382.409955485 1.0 2.5079167176774773 0.7735005927613213 24.29371881881988 -6.676857841615965 1.9127947643755667 1.9567703951846327 0.7802265522246024 0.309793769380884 0.639538603113685 0.4456155858549082 3.1493705525907836 0.26853755610684854 0.7111803711148705 2.104467186017428e-07 6.676857841615965 -1.1765438429600303 EHNFTRPNEK(ub)GEYEVAEGIGSTVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHNFTRPNEKGEYEVAEGIGSTVFR 25 2 B7Z503;Q9BSF8;Q9BSF8-2 B7Z503 BTBD10 BTB/POZ domain-containing protein 10 1 12931900.0 2778900.0 4491700.0 5661300.0 True False 3806334.4269487923 4293241.841934403 4324217.538133397 1.0 1.1279202929564764 1.1360582263917747 21.859970892603112 -13.155298441562293 0.40123739156077176 2.5720785635889587e-13 1.1365391054750156 0.9998190094789936 0.0008382396104697836 13.487889430866437 0.2077687259615924 11.447538780253357 0.002075593462272365 6.993612388198399e-14 13.155298441562293 1.1365391054747584 EHNFTRPNEK(ub)GEYEVAEGIGSTVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHNFTRPNEKGEYEVAEGIGSTVFR 25 2 B7Z503;Q9BSF8;Q9BSF8-2 B7Z503 BTBD10 BTB/POZ domain-containing protein 10 1 20122200.0 4584300.0 10915000.0 4622900.0 True False 3812048.568924545 10856198.728542145 5589527.016125447 1.0 2.847864745753986 1.4662790662455711 21.862135069920456 -6.571927829268337 2.2987276102899616 2.264404587818227 1.4692345095810395 0.0 0.8044055176937096 0.7239821417528503 7.1841088098309696 0.2953404580612946 0.9012427082454141 2.6796135839996184e-07 6.571927829268337 -0.7951700782371873 EHNFTRPNEK(ub)GEYEVAEGIGSTVFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHNFTRPNEKGEYEVAEGIGSTVFR 25 2 B7Z503;Q9BSF8;Q9BSF8-2 B7Z503 BTBD10 BTB/POZ domain-containing protein 10 1 74892000.0 13556000.0 50352000.0 10984000.0 True False 17548509.22870905 47549866.93703468 8985024.705357436 1.0 2.7096242944240494 0.5120107120357605 24.06484514091233 -6.699046274454609 1.8339799048853216 2.0625650424258155 0.5185952435199633 0.4132197277175129 0.7217756583636423 0.39749074607954915 2.5984917992446714 0.3140315447256301 0.8086456615026557 1.9996487939638155e-07 6.699046274454609 -1.5439697989058523 EHPFLVK(ub)GGEDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHPFLVKGGEDLR 13 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 21986200.0 5087500.0 4905700.0 11993000.0 True False 4926000.097256702 6864571.592887539 8851673.517712105 1.0 1.393538663693984 1.7969292210614483 22.231985225644962 -6.970816336817363 0.2378885908016262 0.8513077010512721 2.3507971959696112 0.9999880663738505 0.001123920705660649 0.07603875528215222 0.008076634729560711 0.00978838714711585 0.03947592899056841 1.0695070782556766e-07 6.970816336817363 1.4994894949183393 EHPYDAAK(ub)DSILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHPYDAAKDSILR 13 1 Q16864;Q16864-2 Q16864 ATP6V1F V-type proton ATPase subunit F 1 30570000.0 6972700.0 7578300.0 16019000.0 True False 9141277.22372285 6447647.179982028 14361507.545098318 1.0 0.7053332944820349 1.5710613728930858 23.123964322747288 -6.814851789907634 1.3938689194491984 0.8402949456478398 1.5879700805942818 0.872132938501688 0.12851105695049106 0.2002761297937027 0.7658990516566294 0.07247226774579278 0.16731953149847675 1.5316100594780054e-07 6.814851789907634 0.747675134946442 EHPYDAAK(ub)DSILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHPYDAAKDSILR 13 1 Q16864;Q16864-2 Q16864 ATP6V1F V-type proton ATPase subunit F 1 59418100.0 11369000.0 7277100.0 40772000.0 True False 11008097.318075975 10182883.979575165 30092590.0662184 1.0 0.925035788233289 2.7336776916756094 23.392061793696033 -6.897231134931541 0.9786181143595443 0.9189845075855202 2.9131943417287016 0.9851373319452656 0.10185712876098517 0.11347178755068156 0.18914219504898835 0.07845192716192373 0.20142302659911546 1.2669773910828154e-07 6.897231134931541 1.9942098341431813 up EHPYDAAK(ub)DSILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EHPYDAAKDSILR 13 1 Q16864;Q16864-2 Q16864 ATP6V1F V-type proton ATPase subunit F 1 130604000.0 10428000.0 49564000.0 70612000.0 True False 15820038.38891793 40718916.954700425 56655507.249660976 1.0 2.573882310122861 3.5812496693654445 23.91524976487144 -8.378360695058538 0.21367058663744393 2.7499814100182033e-14 4.66398335691288 0.9996536673027939 0.019767874358942804 0.11714486727331398 0.051907542739459224 0.47154686154486386 0.44065030501259067 4.1844588845042696e-09 8.378360695058538 4.663983356912852 EHPYDAAK(ub)DSILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHPYDAAKDSILR 13 1 Q16864;Q16864-2 Q16864 ATP6V1F V-type proton ATPase subunit F 1 37544800.0 6972700.0 7771100.0 22801000.0 True False 9550695.620132376 7427747.106408814 17415873.40133534 1.0 0.7777179172951031 1.8235188403055766 23.18717438427018 -6.851145156752048 1.2295417050354183 0.8812561352180645 1.8662610761178204 0.9419573231362013 0.1083782844777588 0.15620111234893666 0.4538365117130848 0.06895260907619677 0.15968252376514788 1.4088178423999325e-07 6.851145156752048 0.985004940899756 EHPYDAAK(ub)DSILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHPYDAAKDSILR 13 1 Q16864;Q16864-2 Q16864 ATP6V1F V-type proton ATPase subunit F 1 54410000.0 11369000.0 15294000.0 27747000.0 True False 9453827.232097205 15211608.186378697 33548769.41236726 1.0 1.6090423288816762 3.5486971137428873 23.17246706913031 -6.950099724163171 0.5577465852523104 0.9743263835057997 4.275754603745913 0.999209094108662 0.03056246452192176 0.08344570009412557 0.03579666505096818 0.032851100494378144 0.16116012162938803 1.1217608422195784e-07 6.950099724163171 3.3014282202401133 EHPYDAAK(ub)DSILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHPYDAAKDSILR 13 1 Q16864;Q16864-2 Q16864 ATP6V1F V-type proton ATPase subunit F 1 173791000.0 10428000.0 43623000.0 119740000.0 True False 13499251.56661093 41195341.702301145 97948548.63615239 1.0 3.0516759761847663 7.25585030791029 23.68637608696389 -6.959567284979089 0.44149010511399867 0.8519908555961484 9.619856231864528 0.9997538120326271 0.0408553257975626 0.07985606386360249 0.02170521689626342 0.055533807142190694 0.3482454281898701 1.0975712310593425e-07 6.959567284979089 8.767865376268379 EHPYLFSQCQAIHCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHPYLFSQCQAIHCR 15 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 18302300.0 4512400.0 6876300.0 6913600.0 False True 5915800.098143761 5850382.843607459 6198246.991934061 1.0 0.9889419430252844 1.0477444959438242 22.49614187221936 -6.858070447243652 1.1954485603868448 0.9940284269435847 1.0504887926829443 0.9512505010453441 0.005633729955204306 0.14880407405541227 0.4051888939268176 0.003678401818554657 0.008568690340804453 1.386530900380227e-07 6.858070447243652 0.05646036573935953 EHPYLFSQCQAIHCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHPYLFSQCQAIHCR 15 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 11819000.0 4512400.0 3376600.0 3930000.0 False True 6180756.223024846 3227410.647076986 3001814.9408906535 1.0 0.5221708364834198 0.48567114323456895 22.559351933742253 -13.999999999999986 0.36478370328985954 7.441570542793582 0.4815729274476315 0.9997818372854566 0.0034610997205267824 22.22269134223902 0.19558733820062452 111.68242571994696 0.010370665322399556 1.0000000000000327e-14 13.999999999999986 -6.959997615345951 EHSAFGDRPEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHSAFGDRPEKR 12 2 F1T0I1;O15027-2;O15027-4;O15027-3;O15027;O15027-5;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5 F1T0I1 SEC16A Protein transport protein Sec16A 1 8001000.0 1361300.0 2912200.0 3727500.0 True False 1784677.4828479525 2477711.1116666873 3341814.0567047866 1.0 1.3883242969552154 1.8725030650198975 20.767231951177422 -6.968146851868244 0.2991579802629337 0.9151824812291716 2.3607980665409407 0.9999641040712117 0.002138376734522168 0.07690871960500802 0.011171035776084878 0.008066412788270699 0.04346271743974199 1.0761012803756433e-07 6.968146851868244 1.4456155853117691 EHSAFGDRPEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHSAFGDRPEKR 12 2 F1T0I1;O15027-2;O15027-4;O15027-3;O15027;O15027-5;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5 F1T0I1 SEC16A Protein transport protein Sec16A 1 13725900.0 2799100.0 4039900.0 6886900.0 True False 2710244.1026498736 5653053.1378001915 5083014.2874286175 1.0 2.085809588986121 1.8754820949370674 21.36999136548737 -10.179650008419554 4.797942586923431 0.9998865069504014 1.9806458419651063 0.9666498222187732 0.08586583989706718 0.00010438705600716577 1.7847887889303364e-05 0.08314874173636665 0.027713080658798996 6.612261058101963e-11 10.179650008419554 0.9807593350147049 EHSAFGDRPEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 EHSAFGDRPEKR 12 2 F1T0I1;O15027-2;O15027-4;O15027-3;O15027;O15027-5;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5 F1T0I1 SEC16A Protein transport protein Sec16A 1 10630700.0 2346200.0 2188600.0 6095900.0 True False 3559356.9301955584 1798027.230390152 4891042.693072118 1.0 0.5051550787550168 1.3741366176511536 21.763185182026664 -6.752252893559942 1.6415880089648813 0.7098111124550449 1.376154916493966 0.6585524867001171 0.20796443732074246 0.29614385306957103 1.5708450846210233 0.1000486909125452 0.24231172113776142 1.7690785080933368e-07 6.752252893559942 0.666343804038921 EHSAFGDRPEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHSAFGDRPEKR 12 2 F1T0I1;O15027-2;O15027-4;O15027-3;O15027;O15027-5;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5 F1T0I1 SEC16A Protein transport protein Sec16A 1 10604200.0 1361300.0 4754700.0 4488200.0 True False 1864609.3977492512 4544621.632309707 3428179.597380522 1.0 2.4373049056791563 1.8385510667910603 20.830442012700313 -9.935261944006664 5.3931802965849895 0.9999979403799585 2.137927986239945 0.8280556685630657 0.24444023115171595 6.0537842396954256e-06 1.1953945005303614e-06 0.23667866267143248 0.07889274536368507 1.1607482992259777e-10 9.935261944006664 1.1379300458599868 EHSAFGDRPEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHSAFGDRPEKR 12 2 F1T0I1;O15027-2;O15027-4;O15027-3;O15027;O15027-5;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5 F1T0I1 SEC16A Protein transport protein Sec16A 1 9530000.0 2799100.0 5327500.0 1403400.0 True False 2327575.6711551803 5298799.700074042 1696844.45141155 1.0 2.2765316572690577 0.7290179530744978 21.150396640921645 -6.687604974774628 1.8747549146778169 1.8021147973652178 0.7345028199700652 0.3591899218335687 0.5401530474837665 0.42190951540338206 2.873106181218311 0.23064326639338018 0.6024685813514952 2.0530287220253525e-07 6.687604974774628 -1.0676119773951527 EHSAFGDRPEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHSAFGDRPEKR 12 2 F1T0I1;O15027-2;O15027-4;O15027-3;O15027;O15027-5;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5 F1T0I1 SEC16A Protein transport protein Sec16A 1 7754900.0 2346200.0 1895500.0 3513200.0 True False 3037202.1505161673 1790013.7587215863 2873833.648476124 1.0 0.5893627325456018 0.9462108565897468 21.534311504119113 -10.176042707138729 7.636118136669 1.0000001185909875 0.7677867945676743 0.3608615827584891 0.14568263659625874 2.940306081159057e-07 3.1792401713119477e-08 0.14105667885743434 0.04701886878074146 6.667412007796641e-11 10.176042707138729 -0.23221332402331318 EHSAFQAPAVK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHSAFQAPAVKK 12 1 G3XAN4;Q15629-2;Q15629 G3XAN4 TRAM1 Translocating chain-associated membrane protein 1 1 2879260.0 344060.0 990800.0 1544400.0 True False 333138.0036289227 1386431.6069537417 1139875.3089931274 1.0 4.161733551414526 3.4216309654746477 18.345760417219886 -10.521730736834028 8.866204842535733 0.9998395170660331 3.791682258444584 0.9499270269690432 0.30214561547783975 0.00095853742982617 5.170673119255876e-05 0.2925649040060261 0.09751707807293862 3.007940651890062e-11 10.521730736834028 2.791842741378551 EHSSDQPAAASVWK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHSSDQPAAASVWKR 15 1 E7ESC7;Q7L5Y9;Q7L5Y9-3;Q7L5Y9-2;B4DQT1;B4DVN3;D6REW7;D6RIB6;Q7L5Y9-4;D6RDW4;Q7L5Y9-5;D6RID6 E7ESC7 MAEA Macrophage erythroblast attacher 1 13744800.0 2211400.0 2558700.0 8974700.0 True False 2862700.893210913 2416306.0957219363 7341396.688198404 1.0 0.8440651628859893 2.5645000864774308 21.448945508811278 -6.88476002130713 1.0528591859775405 0.8956173696707987 2.698144429312465 0.9773279347968109 0.11697662048606164 0.12349875505176701 0.24749598157685757 0.08518300545068848 0.20873225204844476 1.3038870700804026e-07 6.88476002130713 1.802527059641666 up EHTALLK(ub)IEGVYAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHTALLKIEGVYAR 14 1 P18077;C9K025;F8WBS5;F8WB72 P18077 RPL35A 60S ribosomal protein L35a 1 28871900.0 2578400.0 5908500.0 20385000.0 True False 3380307.369261115 5026974.831152616 18275755.746727593 1.0 1.4871354235018688 5.406536669688237 21.68872300516514 -6.929989712683652 0.7468773583732387 0.9403745788958382 6.210956398673927 0.9965361934571013 0.11608934898750722 0.09264326180657516 0.07770661441882513 0.10575630923112994 0.35465859078508266 1.1749253855624799e-07 6.929989712683652 5.270581819778089 up EHTALLK(ub)IEGVYAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHTALLKIEGVYAR 14 1 P18077;C9K025;F8WBS5;F8WB72 P18077 RPL35A 60S ribosomal protein L35a 1 35497400.0 4788500.0 4874900.0 25834000.0 True False 4636491.688592385 6821472.99226766 19067300.396612536 1.0 1.4712574615524923 4.112441405540678 22.144602138058506 -6.9372944640632195 0.6842679095933211 0.9685116105128397 4.771363652049454 0.9977876612429307 0.0644255327372888 0.08902283400531878 0.06039410265106767 0.0614954994432626 0.23016173251149172 1.1553286307560501e-07 6.9372944640632195 3.802852041536614 up EHTALLK(ub)IEGVYAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EHTALLKIEGVYAR 14 1 P18077;C9K025;F8WBS5;F8WB72 P18077 RPL35A 60S ribosomal protein L35a 1 46233700.0 9982700.0 15303000.0 20948000.0 True False 15144485.733127266 12572060.087115282 16807618.618165415 1.0 0.8301411027523355 1.1098177194224685 23.85228925305041 -6.742324383843814 1.6784139826518618 0.8992067416091064 1.1100589177773632 0.615245705843162 0.07136460248793411 0.31362174238614887 1.7356534766538994 0.03362652870763277 0.08229961624102217 1.8099876690759198e-07 6.742324383843814 0.2108521761682568 EHTALLK(ub)IEGVYAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHTALLKIEGVYAR 14 1 P18077;C9K025;F8WBS5;F8WB72 P18077 RPL35A 60S ribosomal protein L35a 1 30325100.0 2578400.0 4117700.0 23629000.0 True False 3531704.158640024 3935766.398587013 18048316.854530606 1.0 1.114409990700519 5.110370530435536 21.751933066688032 -6.913025727410034 0.8748904548668497 0.8878011853964328 5.661627418054175 0.992013911793081 0.17079881794720211 0.10245062726367604 0.12817049596256339 0.1419620563776371 0.4005953804151642 1.2217272834456086e-07 6.913025727410034 4.773826232657742 up EHTALLK(ub)IEGVYAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHTALLKIEGVYAR 14 1 P18077;C9K025;F8WBS5;F8WB72 P18077 RPL35A 60S ribosomal protein L35a 1 43841900.0 4788500.0 9030400.0 30023000.0 True False 3981849.916518381 8981751.442805948 36300670.48933232 1.0 2.2556730241252643 9.116534086014125 21.925007413492782 -6.937847111247238 0.6792973573262516 0.9193681747996248 10.85510902082413 0.9978680881835745 0.16470845476841176 0.08876272372006483 0.05918625408180773 0.15782738248962744 0.5963184579799288 1.1538593902543293e-07 6.937847111247238 9.935740846024506 EHTALLK(ub)IEGVYAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHTALLKIEGVYAR 14 1 P18077;C9K025;F8WBS5;F8WB72 P18077 RPL35A 60S ribosomal protein L35a 1 80856700.0 9982700.0 16425000.0 54449000.0 True False 12922801.938435657 15510934.311264595 44539840.693919 1.0 1.2002764094937632 3.446608630706189 23.62341557514286 -6.924392018729933 0.7914730257412044 0.957833307923459 3.848156937045305 0.9953165250072809 0.07590600557738904 0.09565581421490545 0.0927249596589184 0.06697134077353382 0.20986883606671353 1.1901672108644423e-07 6.924392018729933 2.8903236291218457 up EHVEAIK(ub)IGLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHVEAIKIGLTK 12 1 O95229;O95229-2 O95229 ZWINT ZW10 interactor 1 19339300.0 5371700.0 6492000.0 7475600.0 True False 7042350.719616794 5523418.905617793 6702096.623018731 1.0 0.7843146593412416 0.9516845851413975 22.74762564668886 -9.876900896511788 5.167634965219082 1.0000002074000545 0.8679996223132712 0.4533556872622785 0.0683284860937509 93023843.10005118 0.00012314579839035588 229.60306984322065 0.02339065821943524 1.3276973960285808e-10 9.876900896511788 -0.13200058508678325 EHVEAIK(ub)IGLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHVEAIKIGLTK 12 1 O95229;O95229-2 O95229 ZWINT ZW10 interactor 1 26897100.0 9114800.0 8099800.0 9682500.0 True False 8825455.663189266 11334092.379899004 7146362.781226327 1.0 1.2842501070140995 0.8097443411373773 23.073239336779114 -6.744492900350587 1.6704277229054378 1.1682452701434538 0.8091952688574983 0.6248405095417745 0.11942511251171542 0.30975808196859256 1.6987585677244206 0.056522898404345275 0.13801430247994004 1.8009725756849276e-07 6.744492900350587 -0.35905000128595554 EHVEAIK(ub)IGLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHVEAIKIGLTK 12 1 O95229;O95229-2 O95229 ZWINT ZW10 interactor 1 11672800.0 5371700.0 0.0 6301100.0 True False 7357762.654734187 0.0 4812909.955228019 1.0 0.0 0.6541268291837682 22.81083570821175 -10.319059381124926 7.5894312519846245 1.00000457111478 0.32706341459188415 0.5852545074090476 0.2670461597608207 2.0654772411034777e-05 1.8532802757534481e-06 0.2585680857104407 0.08618877745185867 4.79667859121745e-11 10.319059381124926 -0.6729411565228959 EHVEAIK(ub)IGLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHVEAIKIGLTK 12 1 O95229;O95229-2 O95229 ZWINT ZW10 interactor 1 18228400.0 9114800.0 9113600.0 0.0 True False 7579360.054104976 9064503.227892045 0.0 1.0 1.1959457214310218 0.0 22.85364461221339 -6.917311064733571 1.2642773644305647 1.1030071199866127 2.0798247391315954e-21 0.9577062109763644 0.10770838646047588 0.12382728917178508 0.39625731372296547 0.07000541528270919 0.1370711728566573 1.2097313494385886e-07 6.917311064733571 -1.1030071199866127 down EHVEEISELFYDAK(ub)SSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHVEEISELFYDAKSSAK 18 1 Q9Y265;H7C4G5 Q9Y265 RUVBL1 RuvB-like 1 1 7913600.0 1819000.0 6094600.0 0.0 True False 1761256.840670261 8528205.562919125 0.0 1.0 4.842113521429188 0.0 20.74817387925548 -6.695374946978192 1.8483288030548604 3.3967306679042943 0.016159099093203767 0.39516387717108115 1.623246199513109 0.40526692873983966 2.6885711955813445 0.7016590260383418 1.8142074721941692 2.0166245644823812e-07 6.695374946978192 -3.3805715688110904 EHVIEALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHVIEALR 8 0 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 0 15392470.0 528170.0 8074500.0 6789800.0 False True 692435.984805556 6869816.074154483 6087256.628360605 1.0 9.92122914594568 8.791074932464662 19.401321175674475 -10.475411557366252 6.720040492650688 0.997506851001111 9.356152039205144 0.9864666159529628 0.4613835256141577 0.01721338683827349 0.0013437327869860543 0.44619785951981406 0.14891089257650797 3.3464816090481256e-11 10.475411557366252 8.358645188204033 EHVIEALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHVIEALR 8 0 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 0 12575500.0 4355200.0 1213100.0 7007200.0 False True 4216946.559915956 1697497.1562329286 5171804.108505982 1.0 0.4025417756934439 1.2264334003343538 22.007767308220625 -6.71216184483389 1.7873170988874403 0.6335289138745361 1.224645639562014 0.47555719984650413 0.251679440447231 0.3706890527260034 2.3096014552901387 0.11199918273220309 0.28380649794851887 1.9401627189017023e-07 6.71216184483389 0.5911167256874779 EHVIEALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHVIEALR 8 0 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 0 14322870.0 528170.0 6185500.0 7609200.0 False True 723448.7222575643 5912204.157286824 5812063.676393172 1.0 8.172250465571965 8.03382948587743 19.464531237197367 -10.544807359289326 7.314835755213057 0.996675052019286 8.103039975724698 0.9997152570974859 0.05651012832462712 0.0030560162505635434 0.00019017246350004358 0.05456950380463112 0.018238565491110463 2.852283178838936e-11 10.544807359289326 7.106364923705412 EHVVAASK(ub)AMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHVVAASKAMK 11 1 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 2907760.0 308010.0 985150.0 1614600.0 True False 403804.0927730829 838169.4600846235 1447536.6803368358 1.0 2.075683419473491 3.5847498978923844 18.623296007675556 -6.966345620530816 0.334153388737679 0.8248277037357398 4.88531545109226 0.9999382564006827 0.008330367834941068 0.0775072577035356 0.013265865655968906 0.021705617283702 0.13119278918108268 1.0805736661549406e-07 6.966345620530816 4.06048774735652 EHVVAASK(ub)AMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHVVAASKAMK 11 1 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 4146190.0 469290.0 1095100.0 2581800.0 True False 454392.64582635876 1532379.1408710575 1905549.1276602247 1.0 3.3723678297747797 4.1936178878837085 18.793579959993096 -9.3989105774832 0.33097622834475116 4.1907037783467765e-22 4.442918677529301 0.9984747993019153 0.05288196496006491 0.7758267126322343 0.13073590707264723 1.1594807174132156 0.2554980786732714 3.9910707122743843e-10 9.3989105774832 4.442918677529301 EHVVAASK(ub)AMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHVVAASKAMK 11 1 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 2847490.0 469290.0 1225000.0 1153200.0 True False 390235.4280720288 1218400.6818565377 1394328.7882056418 1.0 3.1222195480202477 3.573045110471824 18.573985235427372 -9.915569043426757 0.3852442750918092 2.8788987244142437e-21 3.6355509378079 0.9987858216267248 0.0390921300690681 1.2497552988408251 0.17024697508387823 1.5845424767543015 0.11917951989929551 1.2145935110307276e-10 9.915569043426757 3.6355509378079 EHYVDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHYVDLK 7 0 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 34594400.0 2190400.0 19147000.0 13257000.0 False True 2871635.611863776 16290342.234421434 11885292.810123509 1.0 5.672844481772017 4.138858273320271 21.453441263363498 -9.895607281120311 7.361583867708904 0.9999999710508413 4.905851377546149 0.896311259763764 0.6262472471955861 2.958381252226168e-07 4.4185809481950886e-08 0.6063612897490309 0.20212042991639273 1.2717235651562397e-10 9.895607281120311 3.905851406495308 EHYVDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHYVDLK 7 0 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 36802700.0 9834200.0 3857500.0 23111000.0 False True 9522018.70396892 5397819.866596753 17057535.784861535 1.0 0.5668776794511925 1.7913781011322418 23.182836032087014 -6.811095414065518 1.4098881349636916 0.7642563021071922 1.813348755630186 0.8626777840478121 0.18787233286576188 0.20530999315005957 0.8041390568267061 0.10477080965698402 0.24224237760122513 1.5449149859658657e-07 6.811095414065518 1.0490924535229937 EHYVDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EHYVDLK 7 0 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 82571900.0 1575900.0 79233000.0 1763000.0 False True 2390755.513722264 65093252.09974548 1414542.277249648 1.0 27.227063464301775 0.5916716574030983 21.18903517232439 -8.376878802391126 1.9898600688885394e-12 8.77819017079629 16.45866933451523 0.0 12.819815379846313 0.0 1.3613432020625484 3731756772.345634 3731756788.225725 4.198761415570409e-09 8.376878802391126 7.680479163718939 EHYVDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHYVDLK 7 0 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 32582400.0 2190400.0 15231000.0 15161000.0 False True 3000250.073334286 14558044.057818413 11580284.05059625 1.0 4.8522768775869185 3.859772941435733 21.51665132488639 -10.442714937552301 6.735676377473961 0.9994082567830912 4.3560249095113255 0.9384422230832573 0.40518803521237656 0.003600913472737229 0.0002979283491394718 0.39235752564298304 0.13077387603833657 3.608153975190372e-11 10.442714937552301 3.3566166527282344 EHYVDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHYVDLK 7 0 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 11588760.0 9834200.0 1149900.0 604660.0 False True 8177573.028928686 1143705.2604627195 731091.6103680398 1.0 0.13985876450345222 0.0894020276898484 22.96324130752129 -13.428781415089373 0.409169361548835 9.999537376565534 0.08699617235282169 0.9998394100482376 0.005295482918649879 17.35834446930291 0.21125514141382257 136.6953697757001 0.012597027019254999 3.725791820323915e-14 13.428781415089373 -9.912541204212713 EHYVDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHYVDLK 7 0 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 5880000.0 1575900.0 1370500.0 2933600.0 False True 2040033.6156331191 1294230.4702336763 2399714.9012779114 1.0 0.6344162470244468 1.1763114504038044 20.96016149441684 -6.724984233527978 1.7415736045675265 0.7787738146012959 1.1757023309368382 0.5358552209934965 0.15375240563910705 0.345714568555928 2.0518379942620593 0.07003096546168222 0.17476893373318164 1.88371747405602e-07 6.724984233527978 0.39692851633554227 EHYVDLK(ub)DR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHYVDLKDR 9 1 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 6373800.0 2623600.0 2894700.0 855500.0 True False 2540315.254086036 4050568.8056610855 631418.8855501291 1.0 1.5945142238333778 0.2485592622941216 21.27657611643342 -6.786610747431302 1.5096143536671944 1.3337397550422916 0.2355041052000664 0.7902389378380813 0.25223134036951367 0.24043567768922838 1.0824628064025055 0.1315350368699186 0.30876381714234713 1.6345162875266408e-07 6.786610747431302 -1.0982356498422252 EHYVDLK(ub)DR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHYVDLKDR 9 1 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 6559640.0 3459500.0 2293700.0 806440.0 True False 4738570.639472221 2192356.7497484097 615975.481153145 1.0 0.46266203810197776 0.12999183256277297 22.176020514032437 -8.411598536709187 0.33655257956832796 1.1333015153212407 1.392095280545509e-17 0.9982610936979418 0.014947034142281079 0.14288748427332945 0.09133123509985926 0.09837752493725326 0.09004671429575965 3.876157927119372e-09 8.411598536709187 -1.1333015153212407 EHYVDLK(ub)DR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHYVDLKDR 9 1 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 7710850.0 2623600.0 4265900.0 821350.0 True False 2181639.6451869323 4242918.749985143 993090.4875066809 1.0 1.9448302378194045 0.4552037224376662 21.056981391867698 -6.735345474940728 1.7039122532624094 1.5651992258941612 0.455224328560748 0.5837416676514318 0.39704661919373735 0.32633077823781526 1.8584390622186646 0.18448983475349415 0.455024631382621 1.839308276390924e-07 6.735345474940728 -1.1099748973334131 EHYVDLK(ub)DRPFFAGLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EHYVDLKDRPFFAGLVK 17 2 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 217462900.0 88396800.0 96313000.0 32753100.0 True False 115889060.83582878 81943475.82513364 29364123.401920214 1.0 0.7070855112133209 0.2533813216720958 26.788169150958982 -7.150548494687776 0.40491264303836855 1.0269406056183126 4.344154199001317e-13 0.9997503924353177 0.0048526962590982724 0.08188625058844444 0.0227549785435646 0.007755030778019289 0.04049333265237129 7.070522445957154e-08 7.150548494687776 -1.0269406056178783 down EHYVDLK(ub)DRPFFAGLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EHYVDLKDRPFFAGLVK 17 2 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 394759900.0 167824400.0 176060000.0 50875500.0 True False 162496906.28443214 246361676.14077082 37549680.31771548 1.0 1.5161007170779182 0.23107935514777792 27.275837010590177 -6.7976827473825105 1.4652388053436407 1.2855934036787766 0.21431397770506985 0.8253485664689102 0.2206503720762421 0.22407276632595954 0.949950155371542 0.11847998117517629 0.2759530353515686 1.5933722622838999e-07 6.7976827473825105 -1.0712794259737068 down EHYVDLK(ub)DRPFFAGLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EHYVDLKDRPFFAGLVK 17 2 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 755325400.0 468776400.0 177939000.0 108610000.0 True False 711168070.945411 146184395.20624736 87143185.89454593 1.0 0.205555340823883 0.12253529011601957 29.405615312565292 -13.999999999999998 0.31909522666580337 9.102125997013822 0.10588636471471757 0.9996917839591168 0.006943913414171424 17.94338177950446 0.18010674809487565 97.00722844712271 0.027738503014090587 1.0000000000000041e-14 13.999999999999998 -8.996239632299105 EHYVDLK(ub)DRPFFAGLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EHYVDLKDRPFFAGLVK 17 2 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 252494800.0 88396800.0 132083000.0 32015000.0 True False 121079485.7936978 126247136.31992814 24453716.369621955 1.0 1.0426798189004145 0.20196415775408563 26.851379212481874 -6.894945535036074 0.9926912943028422 1.0399643077426195 0.12224777844180278 0.9838787376776064 0.049092798678094234 0.11522126011054917 0.1991532500284759 0.037415874129309315 0.09509949378247237 1.273662801325685e-07 6.894945535036074 -0.9177165293008167 down EHYVDLK(ub)DRPFFAGLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EHYVDLKDRPFFAGLVK 17 2 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 417994700.0 167824400.0 207051000.0 43119300.0 True False 139553424.48151758 205935575.16659418 52135346.26888265 1.0 1.4756755409744047 0.37358700771823367 27.056242286024453 -6.789400047661545 1.4986473240003888 1.2660629977185072 0.3620449912741517 0.799399448717119 0.20214210750066253 0.23624677928066154 1.0482120347918884 0.10617051714854252 0.24868898553003763 1.6240520810539754e-07 6.789400047661545 -0.9040180064443555 down EHYVDLK(ub)DRPFFAGLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EHYVDLKDRPFFAGLVK 17 2 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 805690400.0 468776400.0 244120000.0 92794000.0 True False 606840290.7643105 230534507.40127355 75906444.14684431 1.0 0.3798932122831152 0.1250847138894498 29.17674163465774 -9.519697828456849 0.26915829209544073 1.3988408356387962 7.624234908606461e-17 0.9989147090858431 0.012103990649561016 0.9221454112613449 0.10944885199082506 0.4160611857785882 0.10030125192389466 3.0220536605510554e-10 9.519697828456849 -1.3988408356387962 EIAEAYLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIAEAYLGK 9 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 125763000.0 17708000.0 59696000.0 48359000.0 False True 23215359.48451595 50789589.49318548 43355274.572283536 1.0 2.1877580455758543 1.8675254458670085 24.468576285090826 -10.153996147217141 4.720193789910916 0.999903302067864 2.027641745721037 0.9321143377653315 0.1307344114853335 8128612.07229711 17486139.19548445 5665.073254913015 0.04475386833143513 7.014615213103152e-11 10.153996147217141 1.027738443653173 EIAEAYLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIAEAYLGK 9 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 91471800.0 32986000.0 9539800.0 48946000.0 False True 31938877.485623524 13349091.8893998 36125574.25147473 1.0 0.4179574531199024 1.1310846559255485 24.928810273316905 -6.689672763820246 1.8677451693951483 0.6350114460308683 1.128610852271382 0.3691039719054505 0.24617385650712564 0.4172114058145677 2.8216127107513436 0.10545604494056969 0.2747113293520027 2.0432769517965072e-07 6.689672763820246 0.4935994062405137 EIAEAYLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIAEAYLGK 9 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 146065000.0 17708000.0 57372000.0 70985000.0 False True 24255126.140706502 54837115.33616687 54219804.98196522 1.0 2.2608464296599027 2.2353957125364143 24.531786346613718 -10.195446782803225 5.3822841520713895 0.9999416704965429 2.248121071098019 0.9996882455934163 0.010390211757521231 7.27337402295234e-06 1.0872381672295184e-06 0.010060744039482065 0.0033534264249249044 6.376072068015087e-11 10.195446782803225 1.248179400601476 EIAEAYLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIAEAYLGK 9 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 57015700.0 32986000.0 14970000.0 9059700.0 False True 27429320.527571302 14889353.638687639 10954041.382680062 1.0 0.542826193004716 0.39935518532693215 24.70921554875118 -13.999999999999998 0.1622346479922687 3.2624767562520964 0.26173671965995526 0.9995306692800234 0.005548539409255418 12.025339299897084 0.12735770828210397 8.56014200830752 0.12578826945322855 1.0000000000000041e-14 13.999999999999998 -3.0007400365921413 EIAEAYLGK(ub)TVTNAVVTVPAYFNDSQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIAEAYLGKTVTNAVVTVPAYFNDSQR 27 1 P11142;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 64892000.0 25547000.0 11786000.0 27559000.0 True False 24736024.46872081 16492211.263178045 20340471.147721794 1.0 0.6667284504036924 0.8223015454016356 24.560110315692558 -10.092231548289782 4.698182536978031 1.0000126204446493 0.744514997902877 0.7824120031096011 0.06351245009470852 9.236636802197358e-06 1.7847577428218488e-06 0.06149900511231794 0.020498555121653137 8.086646368758032e-11 10.092231548289782 -0.25549762254177233 EIAEAYLGK(ub)TVTNAVVTVPAYFNDSQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIAEAYLGKTVTNAVVTVPAYFNDSQR 27 1 P11142;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 80727000.0 15919000.0 25202000.0 39606000.0 True False 24150286.834789477 20704506.19587526 31777856.7400735 1.0 0.8573192665376368 1.3158376526731845 24.525536988372828 -6.823121715738987 1.358455117564995 0.9233305664477365 1.326522009379506 0.8913827800172351 0.06314158134385713 0.1894573195441942 0.6861465242030039 0.036518565595626586 0.08410163467457332 1.5027207532781733e-07 6.823121715738987 0.40319144293176956 EIAEAYLGK(ub)TVTNAVVTVPAYFNDSQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIAEAYLGKTVTNAVVTVPAYFNDSQR 27 1 P11142;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 56833000.0 25547000.0 17025000.0 14261000.0 True False 21243462.423993953 16933282.945802104 17242909.164586063 1.0 0.7971056039657824 0.8116807336035126 24.340515591126834 -10.150651725841866 5.153154490357535 1.0000082141219224 0.8043931687844584 0.9958531931259681 0.0059502717585527 5.615575958010421e-07 9.255287672719242e-08 0.0057615677353584265 0.0019204419520953483 7.068841992989075e-11 10.150651725841866 -0.195615045337464 EIAEAYLGK(ub)TVTNAVVTVPAYFNDSQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIAEAYLGKTVTNAVVTVPAYFNDSQR 27 1 P11142;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 68880000.0 15919000.0 23265000.0 29696000.0 True False 20607459.310402714 21970282.298421353 24291632.706691004 1.0 1.0661325089857479 1.178778632571581 24.296663310465277 -6.96305895065755 0.3899353537594752 0.9930767003798175 1.2558814987352123 0.9998673642775945 0.0008499734870576719 0.07862599527986455 0.0172220812375894 0.0014544411852178104 0.009475849124888218 1.0887822931859612e-07 6.96305895065755 0.2628047983553947 EIAEAYLGYPVTNAVITVPAYFNDSQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIAEAYLGYPVTNAVITVPAYFNDSQR 27 0 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 101762000.0 5716000.0 76917000.0 19129000.0 False True 8671589.895574883 63190560.394736014 15348144.765461445 1.0 7.287078973485841 1.769934343100521 23.0478650984317 -6.614659705327509 2.1366129712116204 5.187244305608678 1.7904464692032414 0.06505390240673159 2.707374794596563 0.5999291893494646 5.196560527496805 1.043964233456647 3.003474175002473 2.42851222859476e-07 6.614659705327509 -3.3967978364054363 EIAEAYLGYPVTNAVITVPAYFNDSQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIAEAYLGYPVTNAVITVPAYFNDSQR 27 0 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 28190100.0 5716000.0 9705100.0 12769000.0 False True 7399474.679204839 9165002.653531445 10445173.021004086 1.0 1.2386017995694165 1.4116100769097495 22.81899142052415 -6.97462148427406 0.09751154273644491 0.5543890443615028 2.1002045543657024 0.9999997696527801 8.078411648434419e-05 0.0748298899935761 0.002857750240971078 0.016140822968132473 0.028887981725454395 1.0601773357333123e-07 6.97462148427406 1.5458155100041995 EIAENALGK(ub)HK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIAENALGKHK 11 1 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 34053900.0 1926700.0 19653600.0 12473600.0 True False 2525922.358189341 16721359.489132784 11182951.527220072 1.0 6.619902403144002 4.427274453216509 21.268378863565744 -10.390650632005581 8.214959140597777 0.9999553660213018 5.523588428180253 0.8501899487618169 0.8951366121811837 0.000731815930349525 5.428369098475377e-05 0.8667202522429419 0.28890409929652094 4.067704238606851e-11 10.390650632005581 4.523633062158951 EIAENALGK(ub)HK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIAENALGKHK 11 1 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 39304600.0 16816000.0 19704200.0 2784400.0 True False 16282185.284613034 27572189.81604556 2055082.1097905093 1.0 1.693396146406821 0.12621660261614884 23.95679100556617 -6.78641463534862 1.510520808436216 1.3893436891077289 0.11112536984637186 0.7895583904907589 0.2941479323136413 0.24072251489857718 1.0850750289791316 0.153308533972254 0.3599089459650903 1.6352545441514875e-07 6.78641463534862 -1.278218319261357 EIAENALGK(ub)HK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIAENALGKHK 11 1 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 130145400.0 2963500.0 25889900.0 101292000.0 True False 4495846.16087057 21269645.066288028 81271591.80213924 1.0 4.730954820342296 18.077040204240866 22.100161239503496 -6.94744388773513 0.5862360983376746 0.8439182279081175 22.631303737847954 0.9989851106278709 0.23353913875078766 0.08452870802959656 0.04033771198341003 0.24306789294568953 1.1168307024233273 1.1286417523066757e-07 6.94744388773513 21.78738550993984 EIAENALGK(ub)HK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIAENALGKHK 11 1 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 29468400.0 1926700.0 13048100.0 14493600.0 True False 2639053.057109735 12471591.797703374 11070510.185061794 1.0 4.725782895536833 4.194879733560987 21.331588925088635 -10.218050415166806 5.126649180793147 0.9996608932113392 4.460331314550636 0.9826517310950498 0.21674030828450908 0.0008401305870658236 0.00012814332183458502 0.2098750259307674 0.06995263370228381 6.052706077089707e-11 10.218050415166806 3.460670421339297 EIAENALGK(ub)HK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIAENALGKHK 11 1 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 33318100.0 16816000.0 2805700.0 13696400.0 True False 13983249.075111846 2790585.137212155 16560253.915001504 1.0 0.19956628979590957 1.184292279000905 23.737196281000447 -6.690487108768681 1.864344755158654 0.4984240524915942 1.1809430582593465 0.37288823686952877 0.338491238088665 0.41560677113036515 2.801038136687477 0.14521443800167197 0.3779638900029876 2.0394491960009652e-07 6.690487108768681 0.6825190057677524 EIAENALGK(ub)HK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIAENALGKHK 11 1 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 121080100.0 2963500.0 28024600.0 90092000.0 True False 3836309.1693183263 26465006.374396726 73696180.42198306 1.0 6.898559319998522 19.2101775871933 21.871287561595945 -6.959201909373398 0.44654725160907466 0.5886618217891492 26.00533635022605 0.9997394218542723 0.1224627567087368 0.07998756817869135 0.022194826988422425 0.16373643167857713 1.0189193800512673 1.0984950155202197e-07 6.959201909373398 25.4166745284369 EIAENALGK(ub)HK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIAENALGKHKER 13 2 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 2 2684760.0 656810.0 1151100.0 876850.0 True False 861084.2705570882 979360.3669526572 786121.9733391261 1.0 1.1373571675151481 0.912944296184316 19.715794909231427 -6.741100328937418 1.6829336542012523 1.0816245511354279 0.9127880939346947 0.6097446836135324 0.057710264021319894 0.31583648070407866 1.756885962477001 0.027124816316790874 0.0664748094682243 1.8150962982016521e-07 6.741100328937418 -0.16883645720073315 EIAENALGK(ub)HK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIAENALGKHKER 13 2 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 2 4614860.0 1672390.0 1704270.0 1238200.0 True False 1619300.8948700032 2384793.8986506388 913878.2747962234 1.0 1.472730550699837 0.5643659419268023 20.626939658239873 -6.76528667377703 1.5925530994874795 1.272779919525375 0.5601512267673933 0.7121600866278317 0.19901269168552232 0.27413491207626983 1.3713651028409106 0.09854541261231481 0.2356024054280576 1.7167747858762077e-07 6.76528667377703 -0.7126286927579818 EIAENALGK(ub)HK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIAENALGKHKER 13 2 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 2 12749370.0 1098000.0 907770.0 10743600.0 True False 1665746.2745523483 745771.3510606178 8620122.750912841 1.0 0.4477100519171421 5.174931430196 20.667737236341083 -6.877787293783262 1.092114200161182 0.6667935740763785 5.495986312437512 0.9718541703075064 0.3540452987477754 0.12960584100740544 0.28431113049005585 0.2502108572414159 0.6017917411176826 1.3249903223293322e-07 6.877787293783262 4.829192738361133 up EIAENALGK(ub)HK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIAENALGKHKER 13 2 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 2 4802090.0 1672390.0 1096000.0 2033700.0 True False 1390666.3844390037 1090095.6304610334 2458937.2672336255 1.0 0.7838656651651066 1.7681719316351805 20.40734493367415 -6.849146396727571 1.23915855375122 0.884739300402929 1.806887040298546 0.9390602113591129 0.1042692248666266 0.15839834313468626 0.46846590321055237 0.06585692767830463 0.15232021341394983 1.415316609155121e-07 6.849146396727571 0.9221477398956169 EIAENALGK(ub)HK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIAENALGKHKER 13 2 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 2 13421800.0 1098000.0 2870300.0 9453500.0 True False 1421382.6448157656 2710565.2818035176 7733060.001101286 1.0 1.9069919642608633 5.440519503531449 20.438863558433532 -6.9454809492723255 0.6064320587790236 0.9606960354482866 6.569706846060952 0.9987972230788333 0.06643602591223148 0.08535273602675393 0.04387490397022791 0.06776077007071026 0.29758746744997505 1.1337545702036685e-07 6.9454809492723255 5.6090108106126655 EIAQDFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIAQDFK 7 0 Q71DI3;Q16695;P68431;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00 Q71DI3;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3;Histone H3.3 0 45163200.0 14518000.0 1817200.0 28828000.0 False True 14057134.036751434 2542817.4365728116 21277081.97853782 1.0 0.18089159781252606 1.5136145051267431 23.744799152474823 -6.740453317503539 1.6855103928993769 0.5128792303893754 1.5144010061008546 0.6067914816370995 0.3441486373438211 0.31698796105700755 1.7684873876329925 0.16153215006383673 0.3961157275852725 1.8178024419430477e-07 6.740453317503539 1.0015217757114792 EIAQDFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIAQDFK 7 0 Q71DI3;Q16695;P68431;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00 Q71DI3;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3;Histone H3.3 0 428500100.0 2246200.0 424330000.0 1923900.0 False True 3407649.619216288 348604996.194578 1543640.3217246747 1.0 102.30071607971018 0.45299267654157777 21.70034557196362 -3.0568059412384994 3.993470312668627e-16 9.074611900133153 83.60372598055012 0.0 49.304753559013385 0.0 0.2447666731828609 47.75201704297201 47.7520182975676 0.0008773927849595556 3.0568059412384994 74.52911408041697 EIAQDFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIAQDFK 7 0 Q71DI3;Q16695;P68431;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00 Q71DI3;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3;Histone H3.3 0 10088400.0 2246200.0 3913700.0 3928500.0 False True 2907750.179221468 3695899.1545812036 3213553.3098139726 1.0 1.2710511312119521 1.1051682956733173 21.47147189405607 -10.205349685393692 3.7611356069476467 0.9998076464133512 1.188109713363616 0.6316191634600385 0.0677213844171537 4365173.912037672 3962008.3524934123 5897.898699348555 0.023182831238750676 6.232328185680447e-11 10.205349685393692 0.18830206695026486 EIAQDFK(ub)TDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIAQDFKTDLR 11 1 Q71DI3;Q16695;P68431;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00 Q71DI3;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3;Histone H3.3 1 390538000.0 166875000.0 132319000.0 91344000.0 True False 218774741.01979876 112577520.9754222 81892599.11351898 1.0 0.5145818957465209 0.37432383067525987 27.704870938229963 -13.999999999999998 0.17409064056389426 3.4752946696044034 0.25583821323832623 0.9995064703511449 0.005955405684603719 12.133979189584439 0.1321988373436893 10.14810151310393 0.1102283226902388 1.0000000000000041e-14 13.999999999999998 -3.219456456366077 EIAQDFK(ub)TDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIAQDFKTDLR 11 1 Q71DI3;Q16695;P68431;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00 Q71DI3;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3;Histone H3.3 1 548927000.0 191200000.0 186850000.0 170877000.0 True False 185130460.6575886 261460179.40987778 126119187.49988249 1.0 1.4123023217311936 0.6812449288566754 27.463967049359464 -6.75369673238304 1.6361962198634723 1.2413597264075904 0.6793765228727469 0.664687502071093 0.17329366915217262 0.29365259322651693 1.5478157185003074 0.08362847719466208 0.20224306145361173 1.7632068630825928e-07 6.75369673238304 -0.5619832035348435 EIAQDFK(ub)TDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIAQDFKTDLR 11 1 Q71DI3;Q16695;P68431;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00 Q71DI3;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3;Histone H3.3 1 870682000.0 268150000.0 376372000.0 226160000.0 True False 406803154.3909034 309205475.9921424 181459376.87055078 1.0 0.7600862300468351 0.446061872706581 28.599755625134208 -6.967422807227344 0.3137000670811326 1.0463121196762324 0.1498003056420335 0.9999547306512779 0.0015260768321428582 0.07714814239139502 0.012009189824127672 0.004887646334785845 0.027781229729189817 1.0778968252059456e-07 6.967422807227344 -0.8965118140341989 down EIAQDFK(ub)TDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIAQDFKTDLR 11 1 Q71DI3;Q16695;P68431;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00 Q71DI3;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3;Histone H3.3 1 548758000.0 166875000.0 211737000.0 170146000.0 True False 228573197.1273094 202381759.21937448 129961019.06686549 1.0 0.8854133457592275 0.5685750591066919 27.768080999752854 -6.953268387930039 0.5217312510105234 1.005312782549329 0.43449436631582666 0.9994334351181905 0.0043431621022548715 0.08219929363970147 0.030731911111175486 0.0049067977131803655 0.026175584494450704 1.1136061278523723e-07 6.953268387930039 -0.5708184162335024 EIAQDFK(ub)TDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIAQDFKTDLR 11 1 Q71DI3;Q16695;P68431;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00 Q71DI3;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3;Histone H3.3 1 592559000.0 191200000.0 295845000.0 105514000.0 True False 158991271.59618118 294251224.2643651 127576489.55838542 1.0 1.8507382280187556 0.8024119077581469 27.24437232479374 -6.690860462588579 1.8635318943385593 1.5329298533100264 0.8060130089533707 0.37441025346223356 0.3597396271062576 0.41480371330503946 2.7936074356257437 0.15439895386149718 0.4016043666916431 2.037696677887132e-07 6.690860462588579 -0.7269168443566557 EIAQDFK(ub)TDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIAQDFKTDLR 11 1 Q71DI3;Q16695;P68431;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00 Q71DI3;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3;Histone H3.3 1 880690000.0 268150000.0 405233000.0 207307000.0 True False 347125461.026728 382681427.32156426 169579253.14944774 1.0 1.1024297272509738 0.4885243872571781 28.370881947226657 -6.8640203216902 1.1652653564441087 1.0562873434571889 0.45643252080066743 0.9583389377664474 0.0548099248925785 0.1427207638896079 0.3659887353255781 0.03662137198123171 0.08590975461339176 1.367664827750258e-07 6.8640203216902 -0.5998548226565215 down EIAQEFKTDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIAQEFKTDLR 11 1 Q5TEC6;A0A590UJL8 Q5TEC6 HIST2H3PS2 Histone H3 0 18780800.0 2186200.0 6544600.0 10050000.0 False True 2866129.3711909163 5568171.190650988 9010122.406407272 1.0 1.942749425974912 3.143655166781059 21.450672300683884 -6.967830890922708 0.30559349075854236 0.8050943355221585 4.319241464480889 0.9999601745614108 0.0055361337630045965 0.0770130408153846 0.011536520808664895 0.019391346163002428 0.10708286658784981 1.0768844579290565e-07 6.967830890922708 3.5141471289587307 EIAQEFKTDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIAQEFKTDLR 11 1 Q5TEC6;A0A590UJL8 Q5TEC6 HIST2H3PS2 Histone H3 0 52033200.0 2186200.0 15221000.0 34626000.0 False True 2994497.2198335514 14548485.890883986 26448051.944854945 1.0 4.858406878632087 8.832217899445922 21.513882362206775 -7.25369544240253 0.28178724481151435 3.9016429283507067e-25 12.68897976268916 0.9999098889342336 0.030353858526928953 0.1070082121263396 0.01857584584601131 0.15590441574010966 0.5623440413023639 5.575766234999143e-08 7.25369544240253 12.68897976268916 EIASK(ub)GLC ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIASKGLC 8 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 3512910.0 1390300.0 974410.0 1148200.0 True False 1346165.6875117428 1363496.9944810208 847451.9747383503 1.0 1.0128745719268133 0.6295302150397127 20.360424558648695 -6.8991294903705445 0.9667700858646595 1.0163209809388225 0.5899977796658217 0.986127770470757 0.02093587360072981 0.1120483661894304 0.1810624551155207 0.0162682220921522 0.042144572899222056 1.2614513608993638e-07 6.8991294903705445 -0.42632320127300083 EIASK(ub)GLC ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIASKGLC 8 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 52883300.0 3884400.0 5941900.0 43057000.0 True False 5892918.787678634 4881521.520723399 34546765.07744652 1.0 0.8283707440411462 5.862420020055179 22.49055095337885 -6.899008231606405 0.9675399363160212 0.7849690152939772 6.380270066407294 0.9860657095872395 0.2754750673813698 0.11213818707003365 0.1815759991422932 0.21393653020474582 0.5538936190121722 1.2618036181707908e-07 6.899008231606405 5.595301051113317 up EIASK(ub)GLC ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIASKGLC 8 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 5448290.0 1390300.0 729990.0 3328000.0 True False 1156096.0507331097 726057.3989783291 4023869.413066578 1.0 0.6280251528563893 3.480566697304208 20.14082983408297 -6.874102731455714 1.1122319255097153 0.7834098347071469 3.661134930490643 0.9686058269968507 0.2243442327042785 0.1329785604837135 0.3049870043870665 0.1561237637113172 0.3724794604235832 1.3362793850507119e-07 6.874102731455714 2.877725095783496 up EIASK(ub)GLC ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIASKGLC 8 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 36696500.0 3884400.0 5409100.0 27403000.0 True False 5028432.372971182 5108078.830018962 22415935.178524185 1.0 1.0158392220756305 4.457837655133689 22.2616772754713 -6.907909677751916 0.909853108714194 0.886256637077428 4.883327354182994 0.9901085409307887 0.16174696225571958 0.10581646349880168 0.14638569666373621 0.13107078609781495 0.35678248885508174 1.2362045059255903e-07 6.907909677751916 3.9970707171055655 up EIAVTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIAVTVK 7 0 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 21521400.0 9611200.0 4458700.0 7451500.0 False True 12600376.274993211 3793479.339876474 6680490.259835196 1.0 0.3010607982719562 0.5301818067999556 23.58696348063207 -10.302322609554476 5.200574896953921 1.0001375207243013 0.4156213025361609 0.8966254996818038 0.09353826004116567 0.00014918126416347657 2.0013209827230016e-05 0.09058909483034269 0.03018934361435124 4.985140357367971e-11 10.302322609554476 -0.5845162181881404 EIAVTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIAVTVK 7 0 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 13172600.0 3680200.0 2308000.0 7184400.0 False True 3563374.065439635 3229596.4360609977 5302590.112619921 1.0 0.906331015703383 1.4880812441355937 21.76481250775699 -6.865652141882366 1.156925395774881 0.9481951349147625 1.5194397568799192 0.9601435886121634 0.05091731736508229 0.14108759162348514 0.3556967107577495 0.0342400511983847 0.0805024212939269 1.362535599622653e-07 6.865652141882366 0.5712446219651567 EIAVTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIAVTVK 7 0 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 29171500.0 4927400.0 17804000.0 6440100.0 False True 7475226.041192384 14626737.096713098 5167211.4122039 1.0 1.9566949569300203 0.6912448377788011 22.833685774531464 -6.704484055223295 1.8147074941256436 1.5914309152794157 0.6946526622763951 0.43897085696920424 0.40351030778431246 0.38626080349363073 2.4759304440585175 0.17717930083946407 0.45318216435924946 1.9747673800931405e-07 6.704484055223295 -0.8967782530030206 EIAVTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIAVTVK 7 0 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 20626600.0 9611200.0 4634300.0 6381100.0 False True 13164720.372913847 4429541.302419267 4874015.602879741 1.0 0.33647059542054236 0.37023312799776076 23.65017354215496 -9.979794534469752 5.313188470226256 1.0000022561616766 0.35335186170710026 0.9979596330315311 0.0137834962148504 4.0089591818389727e-07 7.699233615953799e-08 0.013345863319580766 0.004448604273159913 1.0476240637275014e-10 9.979794534469752 -0.6466503944545763 EIAVTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIAVTVK 7 0 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 9697500.0 3680200.0 4034900.0 1982400.0 False True 3060249.3605034864 4013163.1928350586 2396910.674418023 1.0 1.3113843743030125 0.7832403154309203 21.545217783191266 -6.746947365976766 1.661049392615866 1.1837715074479063 0.782426556514295 0.6357075201145029 0.13083170600350638 0.3054318588898373 1.6570400126551739 0.062244832257817476 0.15160664091677697 1.7908228784400943e-07 6.746947365976766 -0.4013449509336112 EIAVTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIAVTVK 7 0 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 20299500.0 4927400.0 11469000.0 3903100.0 False True 6378616.433574863 10830740.067938728 3192775.849187965 1.0 1.6979763841778295 0.5005436339426652 22.604812096623913 -6.748688330273405 1.6546082667354465 1.411061376097448 0.4983864034948443 0.6433465091668252 0.2932777847567887 0.3023373963735494 1.628109862330904 0.14004109619865482 0.3404635791520938 1.783658343645872e-07 6.748688330273405 -0.9126749726026037 EIAVTVK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIAVTVKK 8 1 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 1 6629010.0 3101300.0 2680500.0 847210.0 True False 4065834.3330319207 2280579.848507167 759548.8362121688 1.0 0.5609131267300118 0.18681253932099295 21.955120001481113 -7.860217394492185 0.3420137323207353 1.0829367569193658 3.4392618906306354e-22 0.9988544851174584 0.011248047375744653 0.11111707472030408 0.06061665218206003 0.041835858882477255 0.08279396953311394 1.379693459506691e-08 7.860217394492185 -1.0829367569193658 down EIAVTVK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIAVTVKK 8 1 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 1 6642180.0 3101300.0 2546200.0 994680.0 True False 4247934.4194811955 2433700.464842571 759757.0700776388 1.0 0.5729138504778991 0.17885329552013865 22.018330063004004 -7.77093048409168 0.3640387123694578 1.0651270668074153 3.938686741687637e-14 0.9987048747988908 0.012067519455842066 0.11690309466237604 0.06027660320949499 0.034123058266667686 0.0789958386790753 1.694609028526865e-08 7.77093048409168 -1.065127066807376 down EIAVTVK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIAVTVKK 8 1 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 1 14772410.0 4961000.0 8825200.0 986210.0 True False 4125291.3095640903 8777656.895934958 1192421.9512801652 1.0 2.1277665593178368 0.28905157522225156 21.976064568930944 -6.740739656817115 1.6838723949441288 1.6704510924395404 0.2877811324525299 0.6082581641693408 0.47383471887121603 0.31650529624062257 1.762365746214654 0.2225800702408013 0.545773107478281 1.816604322298664e-07 6.740739656817115 -1.3826699599870105 EIAVTVK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIAVTVKK 8 1 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 1 11322900.0 7582500.0 1683700.0 2056700.0 True False 9815695.723420342 1590000.6149087495 1682401.7035240913 1.0 0.16198552397208005 0.1713991296113494 23.226659096939866 -10.023965778382488 6.273543424170047 1.0000006274979432 0.16669232687073524 0.9999042978007356 0.0038430884094009755 3.3728654067628863e-08 5.2544314555851074e-09 0.0037210571516859384 0.0012403514506243547 9.463117260757011e-11 10.023965778382488 -0.833308300627208 EIDAYIVQAK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIDAYIVQAKER 12 1 E5RGS2;Q9H6H4;Q9H6H4-2 E5RGS2 REEP4 Receptor expression-enhancing protein;Receptor expression-enhancing protein 4 1 26749700.0 10502000.0 10964000.0 5283700.0 True False 13768223.701512653 9328213.937337263 4736993.408829264 1.0 0.6775176042725405 0.3440526179356624 23.714839107321197 -7.215920629464375 0.272585617772343 1.092722858413115 1.7100303989363018e-14 0.9999445026886687 0.001995022606542348 0.09256536088104902 0.014750949721112013 0.01118239762539386 0.04064464346510749 6.082461526143466e-08 7.215920629464375 -1.092722858413098 down EIDEIHSK(ub)YR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIDEIHSKYR 10 1 Q9NS91 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 3200610.0 1174300.0 1274400.0 751910.0 True False 1137022.4892793226 1783274.5659082066 554962.2141835162 1.0 1.5683722905414976 0.48808376212089455 20.116829359043237 -6.763737283791816 1.5982628865527841 1.328603648262414 0.4833720646614126 0.7060858691465584 0.23920594436368725 0.2766851746350739 1.3937433070509713 0.11803910447251496 0.28264563651598273 1.7229104938971637e-07 6.763737283791816 -0.8452315836010014 down EIDEIHSK(ub)YR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIDEIHSKYR 10 1 Q9NS91 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 3873500.0 1174300.0 1636800.0 1062400.0 True False 976482.4803106472 1627982.233520639 1284542.9280174084 1.0 1.6671904169778151 1.3154797489134247 19.897234634477513 -10.058364441327237 4.346207861175994 0.9999627321843931 1.4913350827423868 0.7223838040707811 0.14358527920919834 18643216.40484596 10786431.73413315 6479.07456092119 0.04915306136672176 8.742498343100839e-11 10.058364441327237 0.49137235055799366 EIEELHK(ub)LK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIEELHKLK 9 1 Q96SN7 Q96SN7 ORAI2 Protein orai-2 1 8074800.0 2486700.0 3379700.0 2208400.0 True False 3260087.781237058 2875461.9339674185 1979895.9524686409 1.0 0.8820197880918129 0.6073136937795456 21.636479380360402 -6.9569671266647095 0.4762611954280631 1.0068313953717656 0.4711210606767255 0.9996406331180123 0.0031186925895584036 0.08080291754430179 0.02527393572614747 0.0038443861036949554 0.022664459361585895 1.1041621948076894e-07 6.9569671266647095 -0.53571033469504 EIEELHK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIEELHKLK 9 1 Q96SN7 Q96SN7 ORAI2 Protein orai-2 1 9009490.0 2423000.0 2042190.0 4544300.0 True False 2346083.1912831464 2857647.1168801636 3354011.503922214 1.0 1.2180502070419876 1.429621727133981 21.16182274105534 -6.971494247071517 0.21958438888104567 0.9019191034180645 1.7517241330413083 0.9999918079395982 0.0005019898340485633 0.07582075582322753 0.007270084310406007 0.005879054381462705 0.02146275757277534 1.0678389376885486e-07 6.971494247071517 0.8498050296232438 EIEELHK(ub)LK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIEELHKLK 9 1 Q96SN7 Q96SN7 ORAI2 Protein orai-2 1 7395900.0 3011500.0 2607700.0 1776700.0 True False 4568665.670140622 2142335.560946903 1425534.4662447253 1.0 0.4689193115943112 0.31202424715854676 22.123341440918878 -13.999999999999998 0.17091575949401636 3.6847360518627434 0.17496550768500038 0.9995119607502339 0.006503480528365493 12.100565684637008 0.13093455247753708 10.771812831605827 0.12685594164906705 1.0000000000000041e-14 13.999999999999998 -3.509770544177743 EIEELHK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIEELHKLK 9 1 Q96SN7 Q96SN7 ORAI2 Protein orai-2 1 10771700.0 2423000.0 4329000.0 4019700.0 True False 2014831.857100143 4305678.817760777 4860200.685007122 1.0 2.1369916316281334 2.4122115539716504 20.942228016489615 -10.430180519739354 0.30483364631446674 4.774204446562188e-12 2.496887997667028 0.9990552634837918 0.0187882795517493 1.9610658431473886 0.14605451432946384 1.6341622908033393 0.09657896978336995 3.713808280897196e-11 10.430180519739354 2.4968879976622538 EIEELK(ub)ELLPEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIEELKELLPEIR 13 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 14824820.0 3833800.0 7721500.0 3269520.0 True False 5026148.926572013 6569482.298171259 2931221.433850422 1.0 1.3070608121936107 0.5831943057544068 22.26102198874086 -6.791437982793714 1.490429927286596 1.1712962699094855 0.5751709091837163 0.8059961776294948 0.130660824881249 0.2332133845314326 1.0233755249442946 0.0689959483379922 0.1613795220554394 1.6164490383787097e-07 6.791437982793714 -0.5961253607257693 EIEELK(ub)ELLPEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIEELKELLPEIR 13 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 35098800.0 19619400.0 5003400.0 10476000.0 True False 18996592.886116613 7001283.712386314 7732021.326736584 1.0 0.36855470632858073 0.40702147869828914 24.179237352921575 -9.970401740332532 5.796911834141374 1.0000006579552527 0.38778809251548474 0.9970478035507273 0.01570399406054136 43164285.77550052 12.033381620305027 379.2913182046922 0.0053758948685317855 1.0705285639344644e-10 9.970401740332532 -0.612212565439768 EIEELK(ub)ELLPEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIEELKELLPEIR 13 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 90140600.0 28804600.0 27839000.0 33497000.0 True False 43698684.0983339 22870912.94290023 26876303.26774337 1.0 0.5233776122739638 0.6150369015063335 25.38108650061037 -9.87794283462372 5.449521004333132 1.0000003308219279 0.5692072568872616 0.9671619990559396 0.037419748144511406 11888479.142236667 21549363.057050627 30.893408224160982 0.012809776731549899 1.3245158672852334e-10 9.87794283462372 -0.43079307393466626 EIEELK(ub)ELLPEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIEELKELLPEIR 13 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 20790600.0 3833800.0 6983700.0 9973100.0 True False 5251259.464549387 6675137.04199241 7617659.182441888 1.0 1.2711497283757254 1.4506346970413055 22.324232050263753 -8.50765277528139 0.06459781739370836 5.505033360109448e-07 2.4489446435420663 0.9999961479403459 0.00036350903682858123 0.15401898537169942 0.015772506609394728 0.302972471215823 0.282806883085984 3.1070427209320938e-09 8.50765277528139 2.4489440930387305 EIEELK(ub)ELLPEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIEELKELLPEIR 13 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 56392200.0 19619400.0 25332700.0 11440100.0 True False 16314400.38678933 25196227.716952763 13832172.016953995 1.0 1.5444164124692894 0.8478504688504929 23.95964262835585 -6.698209934648003 1.8375332318414426 1.338654978886013 0.8500088512410607 0.4089938650976873 0.2298811155948915 0.39923877696743143 2.6195863177913137 0.09985896926319686 0.25735317693193155 2.00350331499213e-07 6.698209934648003 -0.4886461276449522 EIEELK(ub)ELLPEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIEELKELLPEIR 13 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 86588900.0 28804600.0 27398300.0 30386000.0 True False 37288122.52355213 25873560.519958686 24856059.786688894 1.0 0.6938820935169446 0.6665945642875737 25.15221282270282 -13.999999999999998 0.34220342003608206 4.588542439072548 0.6624260812837083 0.9997395764226144 0.00243916889176726 19.907585710651574 0.1877838669987582 51.73432624209267 0.008365007038984107 1.0000000000000041e-14 13.999999999999998 -3.9261163577888403 EIFDSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIFDSR 6 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5 P06733 ENO1 Alpha-enolase;Enolase 0 42722600.0 12908000.0 4509600.0 25305000.0 False True 12498242.605481964 6310306.797253326 18676861.366272353 1.0 0.5048955278308893 1.494359003567456 23.575221914090932 -6.7706879731145735 1.5721296604318309 0.7162678116623954 1.5000287212439987 0.7330771928406651 0.20869739357800546 0.2653174031726977 1.2943035330930017 0.10463615171173915 0.24888915669337675 1.6955555661197846e-07 6.7706879731145735 0.7837609095816033 EIFDSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIFDSR 6 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5 P06733 ENO1 Alpha-enolase;Enolase 0 5712600.0 1839300.0 1731800.0 2141500.0 False True 2381010.1080233483 1635423.8076254528 1751768.9736455693 1.0 0.6868613459953509 0.7357251310032622 21.183142314570894 -10.26974215327566 5.539343941593751 1.0000260200170075 0.7112932384993355 0.9789675485854812 0.01994855669510504 6.410902599304723e-06 8.45157776693381e-07 0.019316845641287383 0.0064383689884134525 5.373507343485604e-11 10.26974215327566 -0.288732781517672 EIFFHYSEFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIFFHYSEFK 10 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0;E9PNG3 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 11314300.0 3270500.0 3577500.0 4466300.0 False True 4287657.171567053 3043750.9449857795 4004170.119774803 1.0 0.7098867337551966 0.9338829947337789 22.03175812608702 -9.830112172356472 5.583090914082842 1.000000052373488 0.8218848649113 0.4574242751315174 0.0914460906192085 5.966016405136774e-08 1.2524843960324071e-08 0.08854232289669764 0.029514098836357437 1.4787264039263338e-10 9.830112172356472 -0.17811518746218802 EIFFHYSEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIFFHYSEFK 10 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0;E9PNG3 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 9548800.0 3296800.0 1635700.0 4616300.0 False True 3192144.8885770855 2288843.5400628145 3407152.5439685117 1.0 0.7170237003506059 1.067355230697961 21.60609470499713 -6.691767258104614 1.8598506991349166 0.8228838358001015 1.0661783504889875 0.37872754627240446 0.11963714710291602 0.41294362277564095 2.770681922022844 0.0514303299576597 0.1336446489431389 2.0334464592514813e-07 6.691767258104614 0.24329451468888597 EIFFHYSEFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIFFHYSEFK 10 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0;E9PNG3 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 17993400.0 1881100.0 10984000.0 5128300.0 False True 2853766.226830985 9023819.381616302 4114689.257186265 1.0 3.1620737875354847 1.4418452424379185 21.444435727121338 -6.589052054742379 2.2326182728899626 2.464191611162754 1.4467859470879676 0.0 0.9371226171839936 0.6722847295834894 6.316255283864679 0.35061001383739654 1.044700134591224 2.5760123764336416e-07 6.589052054742379 -1.0174056640747866 EIFFHYSEFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIFFHYSEFK 10 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0;E9PNG3 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 10077000.0 3270500.0 2896800.0 3909700.0 False True 4479692.231939269 2768809.7975634118 2986309.382799035 1.0 0.6180803622673845 0.6666327122893115 22.09496818760991 -10.52435578404381 6.8468719288434405 1.0001980501887962 0.642356537278348 0.9863661228418772 0.019821413894454815 5.995700864016448e-05 4.165163822083915e-06 0.019202441458370172 0.006397333825958987 2.9898143083090004e-11 10.52435578404381 -0.3578415129104482 EIFFHYSEFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIFFHYSEFK 10 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0;E9PNG3 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 7703800.0 3296800.0 2278100.0 2128900.0 False True 2741435.2730036126 2265827.423132554 2574043.1470785593 1.0 0.8265113699547734 0.9389399678433215 21.386499980431406 -10.443313909460127 5.676630262272424 1.0000811146326203 0.8827256689094748 0.5919608048280744 0.045898782887249474 4.7151471994594196e-05 4.623960724134362e-06 0.044471994946064235 0.014813768477792177 3.6031810977743196e-11 10.443313909460127 -0.11735544572314549 EIFFHYSEFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIFFHYSEFK 10 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0;E9PNG3 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 14890300.0 1881100.0 9761500.0 3247700.0 False True 2435121.032024531 9218263.943951866 2656651.9242160725 1.0 3.7855465181079353 1.0909732572952906 21.215562049213787 -6.638418384601703 2.049963296061219 2.8237566548479784 1.1020994532031338 0.14862481095769953 1.1923225104149777 0.5373869825826553 4.314031101478805 0.4739466257947182 1.3204651728792776 2.2992257538839603e-07 6.638418384601703 -1.7216572016448446 EIFGLYGQTTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIFGLYGQTTGK 12 0 Q9NR31;H0Y5E8;Q9NR31-2 Q9NR31 SAR1A GTP-binding protein SAR1a 0 22885300.0 5956900.0 7093800.0 9834600.0 False True 7809553.586701652 6035432.691415818 8817009.932144571 1.0 0.772826849116336 1.1290030645488427 22.8968086520501 -6.734413185498038 1.7071792977184932 0.8639636234152623 1.1289660139697626 0.5795715975448854 0.09546970165818261 0.32803207958094865 1.8748783114410652 0.04428155731988783 0.10933527048349113 1.8432609159069626e-07 6.734413185498038 0.26500239055450026 EIFGLYGQTTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIFGLYGQTTGK 12 0 Q9NR31;H0Y5E8;Q9NR31-2 Q9NR31 SAR1A GTP-binding protein SAR1a 0 11621900.0 4742000.0 3499200.0 3380700.0 False True 3943183.106219094 3480349.115063181 4087588.739409305 1.0 0.882624271131122 1.0366215895382738 21.910929274520274 -6.702968678912415 1.8202527038600953 0.9273274683027642 1.0361903274417508 0.4316872859748925 0.049519358206516845 0.389381293468028 2.5102246029777855 0.021686439173238453 0.05556895359525773 1.9816699376360397e-07 6.702968678912415 0.10886285913898652 EIGFINYYGMQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIGFINYYGMQR 12 0 Q96PZ0;Q96PZ0-2;E7EUH7 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 8235400.0 2387500.0 2769200.0 3078700.0 False True 3130035.6205828916 2356046.154257058 2760145.656975729 1.0 0.7527218344621596 0.8818256376461684 21.577747644803434 -10.10752150522055 4.51809703807663 1.0000169627578142 0.8172737360475708 0.727589512956521 0.052706406964682054 73431072.03054662 1.202262416782861 12958.300418441244 0.018042805008908976 7.806897812962508e-11 10.10752150522055 -0.18274322671024334 EIGNIISDAMK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIGNIISDAMKK 12 1 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 4422800.0 0.0 0.0 4422800.0 True False 0.0 0.0 3264335.99884408 0.0 EIGNIISDAMKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIGNIISDAMKK 12 1 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 16281200.0 5066700.0 7628900.0 3585600.0 True False 7686554.3253865065 6267463.190132245 2876904.5883756895 1.0 0.8153800682098341 0.37427753276576614 22.87390559121656 -6.956425200386049 0.48318660638878586 1.0102766254197273 0.16089085275889747 0.9996137841312864 0.005158863175267454 0.08100369746611458 0.02604412969782397 0.006260178600869592 0.036383797806515863 1.1055408630265956e-07 6.956425200386049 -0.8493857726608298 down EIGVTPASQPGSIIPNSNLDYMFFK(ub)FPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIGVTPASQPGSIIPNSNLDYMFFKFPR 28 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 48650200.0 8231200.0 12894000.0 27525000.0 True False 12487332.181325413 10592964.958718184 22084671.685363915 1.0 0.8482968823845158 1.7685660447466236 23.5739619538171 -6.864583691828719 1.1624571246746234 0.91646631642582 1.817172051826806 0.9589668594272837 0.08160414283551808 0.14214870036582522 0.36244958691439627 0.05464407683371749 0.12827957156891429 1.365891832648274e-07 6.864583691828719 0.900705735400986 EIGVTPASQPGSIIPNSNLDYMFFK(ub)FPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIGVTPASQPGSIIPNSNLDYMFFKFPR 28 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 52148200.0 8231200.0 11803000.0 32114000.0 True False 10655450.661209052 11146152.67432915 26269581.517466146 1.0 1.0460517371551903 2.465365600452735 23.34508827590955 -6.91380525564466 0.8694130874688264 0.9611653940204454 2.6645443391600576 0.9922802280129582 0.0597626031013639 0.10195535891014287 0.1255133816346862 0.049868301168077236 0.14157524669296612 1.219536335267216e-07 6.91380525564466 1.7033789451396122 up EIHLAFLPYEAQVFSLDAPHSTYNLYCPFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIHLAFLPYEAQVFSLDAPHSTYNLYCPFR 30 0 Q15833;Q15833-2;Q15833-3;M0R0M7;M0R0D4 Q15833 STXBP2 Syntaxin-binding protein 2 0 150701000.0 48621000.0 43791000.0 58289000.0 False True 73761611.67122926 35976153.90935531 46768153.60102377 1.0 0.48773546421014313 0.634044627569678 26.136366842818916 -10.615458042936435 9.864204883455768 1.0000706923845748 0.560890045889932 0.9231359243196535 0.0597304658207282 9.287554736650322e-05 3.6207054233225516e-06 0.05784293547749026 0.01927792494874096 2.4240521402147644e-11 10.615458042936435 -0.43918064649464283 EIHLAFLPYEAQVFSLDAPHSTYNLYCPFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIHLAFLPYEAQVFSLDAPHSTYNLYCPFR 30 0 Q15833;Q15833-2;Q15833-3;M0R0M7;M0R0D4 Q15833 STXBP2 Syntaxin-binding protein 2 0 102687000.0 48621000.0 11770000.0 42296000.0 False True 62940842.963194296 11114989.153338471 34598561.9936087 1.0 0.1765942213363451 0.5496996920400443 25.907493164911365 -10.668537171849145 6.531690281122898 1.004355386446108 0.3631469567546417 0.7952778148393713 0.15231967057750015 0.00968516350367316 0.0004914909843507461 0.14785583929697277 0.049160962287204804 2.1451754995000274e-11 10.668537171849145 -0.6412084296914662 EIIDLVLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIIDLVLDR 9 0 F8VVB9;F8VS66;F8VRZ4;P68363;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 108741000.0 17670000.0 41718000.0 49353000.0 False True 23165541.11652342 35493837.015490346 44246424.9874048 1.0 1.5321825135426452 1.9100104230176993 24.46547704643194 -7.335000717756565 0.09948688286593801 3.626214383450685e-20 3.3156987852622373 0.9999987427329508 0.00041851954036782504 0.11589323948848144 0.0062185741489811115 0.07952486095786558 0.12224174203279776 4.623802572248272e-08 7.335000717756565 3.3156987852622373 EIIDLVLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIIDLVLDR 9 0 F8VVB9;F8VS66;F8VRZ4;P68363;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 112309000.0 28746000.0 32744000.0 50819000.0 False True 27833473.964764863 45818849.957704246 37507979.362679146 1.0 1.646177908503536 1.347585264065905 24.730317650457536 -9.991080319100362 4.369024525976246 0.9999813508112676 1.496881586089857 0.7868807829767613 0.12189993704317585 10834791.525239365 3539570.153938129 1957.1158360300913 0.04172959044591614 1.0207506870223691e-10 9.991080319100362 0.4969002352785894 EIIDLVLDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIIDLVLDR 9 0 F8VVB9;F8VS66;F8VRZ4;P68363;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 235762000.0 11576000.0 204350000.0 19836000.0 False True 17561638.318959914 167882145.90616265 15915405.90557233 1.0 9.559594774532712 0.9062597473260637 24.06592410386761 -6.648726293069511 2.0131388031098556 6.56024000916515 0.9428819787009104 0.18867845136018835 3.654553888310763 0.5118187163756895 3.97444634973252 1.4730139467497878 4.047478275343008 2.2452965390588202e-07 6.648726293069511 -5.617358030464239 EIIDLVLDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIIDLVLDR 9 0 F8VVB9;F8VS66;F8VRZ4;P68363;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 100399000.0 17670000.0 42011000.0 40718000.0 False True 24203076.513795108 40154815.10820094 31101247.013533268 1.0 1.6590789640033474 1.2850121345443992 24.52868710795483 -10.050439160512859 4.296234962043929 0.9999620602446777 1.4720455489668685 0.679824216846706 0.15271214394695812 17356446.62620566 8120596.198889021 6050.725723149651 0.05227742854359397 8.90350156732572e-11 10.050439160512859 0.47208348872219075 EIIDLVLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIIDLVLDR 9 0 F8VVB9;F8VS66;F8VRZ4;P68363;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 65167000.0 28746000.0 16548000.0 19873000.0 False True 23903572.663722932 16458852.63947916 24028352.417629845 1.0 0.6885519947592523 1.0052201298802619 24.510722925891812 -11.001175103254951 10.599146839399383 1.157568651578643 0.8468860623170092 0.23764000646643102 0.12927922480753173 0.06274248984770874 6.956121973346734e-06 0.016315686319298382 0.041724690390847925 9.972978820728751e-12 11.001175103254951 -0.3106825892616337 EIIDLVLDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIIDLVLDR 9 0 F8VVB9;F8VS66;F8VRZ4;P68363;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 55174000.0 11576000.0 25583000.0 18015000.0 False True 14985360.197074046 24159283.560735624 14736454.849509675 1.0 1.612192382633073 0.9833900991173391 23.837050425960058 -6.652262439467525 2.0002472793224637 1.3965344262459258 0.9860217888839818 0.20336077214676007 0.261144675069468 0.5030107930141628 3.8600666650033246 0.1057828629602048 0.28932682659237213 2.227088936755728e-07 6.652262439467525 -0.410512637361944 EIIK(ub)QEESVDPDYWEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIIKQEESVDPDYWEK 16 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y5M9;A0A2R8YE38 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 11917800.0 3127100.0 5236800.0 3553900.0 True False 2600322.204018921 5208588.318976586 4297004.058622994 1.0 2.003054971774831 1.6524890846148879 21.31025896693942 -10.067702021527186 4.318414447265854 0.9999240940755473 1.827772028296562 0.8814319038822875 0.14311792453071268 100088892.48371963 148887558.56488568 102309.23873994562 0.0523757987974703 8.556535932452174e-11 10.067702021527186 0.8278479342210147 EIISK(ub)EQGNVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIISKEQGNVK 11 1 Q9NSD9 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 1 6087700.0 1531200.0 1773000.0 2783500.0 True False 1982168.58446439 1674330.9914077402 2276931.561121848 1.0 0.844696563415754 1.1487073193308162 20.918648239026997 -6.767880385608861 1.5829805775506782 0.910679210098626 1.1502652337676238 0.7222315812017754 0.06541672954489901 0.2698737334688826 1.334356548786999 0.03258250660550915 0.07769865930243215 1.7065523468779535e-07 6.767880385608861 0.23958602366899784 EIK(ub)ALLTPEDYQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIKALLTPEDYQR 13 1 Q9BYM8-3;Q9BYM8;A6PVK0 Q9BYM8-3 RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1 1 12215000.0 3570000.0 4148400.0 4496600.0 True False 4680304.571929179 3529474.8903365475 4031334.9664329276 1.0 0.7541122241285528 0.8613403047766286 22.158170985909422 -10.143707370361167 4.657251422353287 1.0000193088168683 0.8077262644513602 0.810859682111275 0.04377568062324769 27534640823.808506 5062517470.372831 6034107.962426221 0.014986031726873433 7.182781073788269e-11 10.143707370361167 -0.1922930443655081 EIK(ub)ALLTPEDYQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIKALLTPEDYQR 13 1 Q9BYM8-3;Q9BYM8;A6PVK0 Q9BYM8-3 RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1 1 15919200.0 4373800.0 6527100.0 5018300.0 True False 4234956.113097077 9133405.068376835 3703856.68422702 1.0 2.1566705355294604 0.8745915153104957 22.013915588292445 -6.669056836934537 1.940589903376467 1.7389125214557644 0.8797893691593817 0.27481956888328185 0.49143924345825574 0.4633566679287942 3.3631541281340525 0.20393278039333626 0.5455533748364026 2.142610175352644e-07 6.669056836934537 -0.8591231522963827 EIK(ub)ALLTPEDYQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIKALLTPEDYQR 13 1 Q9BYM8-3;Q9BYM8;A6PVK0 Q9BYM8-3 RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1 1 35830900.0 9131900.0 16431000.0 10268000.0 True False 13853759.931315655 13498759.674011033 8238525.29937572 1.0 0.9743751689747299 0.5946779314944668 23.72377424323667 -6.920576902449567 0.8204535507785378 1.0082050220062724 0.5326319012471682 0.9943392678975748 0.013943550235975558 0.09783365630009537 0.10386975085212305 0.012050588802361309 0.03629780117541455 1.2006684465042956e-07 6.920576902449567 -0.4755731207591042 EIK(ub)ALLTPEDYQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIKALLTPEDYQR 13 1 Q9BYM8-3;Q9BYM8;A6PVK0 Q9BYM8-3 RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1 1 9649400.0 3570000.0 2874900.0 3204500.0 True False 4889925.475622441 2747877.41197703 2447663.0987491375 1.0 0.5619466852155351 0.5005522294667637 22.221381047432313 -13.999999999999998 0.27682819529365305 4.508486875017547 0.48148474389474405 0.9995981814411082 0.00445785673285008 15.229305002644843 0.16662844190351217 30.19345612651468 0.024657558100057535 1.0000000000000041e-14 13.999999999999998 -4.027002131122803 EIK(ub)ALLTPEDYQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIKALLTPEDYQR 13 1 Q9BYM8-3;Q9BYM8;A6PVK0 Q9BYM8-3 RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1 1 14250100.0 4373800.0 5918700.0 3957600.0 True False 3637008.492193396 5886814.788330039 4785115.862125084 1.0 1.6185870340874118 1.3156735466513279 21.79432086372672 -10.095807153288042 4.7350038271515 0.9999763078865487 1.4671302903205832 0.7602415049825413 0.12366391342771647 86045035.99223703 3.0743399335871313 22926.792448845757 0.042333446830039395 8.02034124344168e-11 10.095807153288042 0.4671539824340345 EIK(ub)ALLTPEDYQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIKALLTPEDYQR 13 1 Q9BYM8-3;Q9BYM8;A6PVK0 Q9BYM8-3 RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1 1 28324000.0 9131900.0 14608000.0 4584100.0 True False 11821424.56666037 13795051.958535973 3749840.8368380372 1.0 1.1669534310984624 0.3172071873142605 23.494900565329118 -6.855709112517977 1.2073096775361543 1.0897354449937051 0.2793235565729238 0.9481934287160917 0.08366896786065069 0.15129329897785662 0.42152010498392645 0.05413959013737503 0.12582181096966077 1.3940902424411768e-07 6.855709112517977 -0.8104118884207814 down EIK(ub)DSTSQHDDDNISTTSGFSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIKDSTSQHDDDNISTTSGFSSR 23 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 15737890.0 7259590.0 4823100.0 3655200.0 True False 9517392.791969553 4103512.280296553 3276994.967154216 1.0 0.43115928595055514 0.3443164571204029 23.182134983062067 -13.999999999999998 0.2646103585529476 5.2662188987541905 0.31395019018474374 0.999571877025412 0.00601682282273846 14.625880998730606 0.16280114368114054 33.457824725279636 0.03706634880431228 1.0000000000000041e-14 13.999999999999998 -4.952268708569447 EIK(ub)DSTSQHDDDNISTTSGFSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIKDSTSQHDDDNISTTSGFSSR 23 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 14506990.0 7259590.0 4469400.0 2778000.0 True False 9943656.606043098 4271927.129670648 2121893.6147059123 1.0 0.4296133001087801 0.21339168263477293 23.24534504458496 -11.750003268229396 0.17006762209509363 2.340631923204025 6.669819991853742e-09 0.9995111241244105 0.007336363938420185 4.738455481640416 0.10846584457594602 2.4650120499240926 0.17099935025549248 1.7782660278675724e-12 11.750003268229396 -2.340631916534205 EIK(ub)DSTSQHDDDNISTTSGFSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIKDSTSQHDDDNISTTSGFSSR 23 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 23005570.0 5643500.0 12556100.0 4805970.0 True False 4692820.299440634 12488457.79710928 5810876.106705408 1.0 2.6611838937446324 1.2382481612172622 22.162023786121306 -6.608388413919969 2.1588149711847566 2.1109786994783573 1.2431689249947468 0.04567055705431067 0.7164687486982327 0.6170980370890923 5.447090146736924 0.27423084035867246 0.7960187526791357 2.463834805870216e-07 6.608388413919969 -0.8678097744836104 EIK(ub)DSTSQHDDDNISTTSGFSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIKDSTSQHDDDNISTTSGFSSR 23 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 38282600.0 12764800.0 18091000.0 7426800.0 True False 16524285.231825398 17084219.946732916 6075198.605403182 1.0 1.033885563402712 0.36765273173223173 23.978084532628134 -6.894921304705314 0.9928315596088351 1.0316897082535545 0.3045094531807087 0.9838652513509076 0.03891855536604703 0.11524030358133242 0.19925742342281075 0.029658349163988008 0.0753751196467943 1.2737338640104912e-07 6.894921304705314 -0.7271802550728459 down EIK(ub)SQQSEVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIKSQQSEVTR 11 1 Q5T123;Q9H299 Q5T123 SH3BGRL3 SH3 domain-binding glutamic acid-rich-like protein 3 1 29138990.0 20508800.0 7865550.0 764640.0 True False 19857759.369949564 11006305.133301368 564357.8452917017 1.0 0.55425715098336 0.028420016315926135 24.243199511235634 -7.77178186974349 0.5781982571435711 1.008496493586438 8.967080517260394e-25 0.9912377248385074 0.037170869339457256 0.11514824948522055 0.13144812030808778 0.038051874857633505 0.07724097121074501 1.69129019164149e-08 7.77178186974349 -1.008496493586438 down EIK(ub)SQQSEVTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIKSQQSEVTR 11 1 Q5T123;Q9H299 Q5T123 SH3BGRL3 SH3 domain-binding glutamic acid-rich-like protein 3 1 11780420.0 10141200.0 605220.0 1034000.0 True False 15384941.821029412 497213.7623945575 829629.4467817 1.0 0.032318208816033644 0.05392476984525829 23.875015652265766 -10.65859540890063 3.0321395577559733 1.0882383591065043 0.043121488125620264 0.9996177447342254 0.008820845419286056 8435212.494956829 8720299.672264222 5801541.708622202 0.003313619443099931 2.194848716195143e-11 10.65859540890063 -1.045116870980884 EIK(ub)SQQSEVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIKSQQSEVTR 11 1 Q5T123;Q9H299 Q5T123 SH3BGRL3 SH3 domain-binding glutamic acid-rich-like protein 3 1 17937060.0 9711400.0 7881110.0 344550.0 True False 13301967.020717021 7532896.500854383 263174.38622999366 1.0 0.56629944196391 0.019784621764594307 23.665136263411956 -7.736734275482688 0.6019710057809338 1.0050832746520524 3.085037966493215e-17 0.9901373814556225 0.03982893260301157 0.11714739216154953 0.13658096167220138 0.03908842070364287 0.07727569031563691 1.8334358730665816e-08 7.736734275482688 -1.0050832746520524 down EILAELTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EILAELTGR 9 0 P08559;P08559-4;P08559-3;P08559-2;Q5JPU0;Q5JPT9;Q5JPU1 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 0 8963100.0 1822200.0 2786500.0 4354400.0 False True 2388921.8462099014 2370765.0616919254 3903848.4583542133 1.0 0.9923995904065332 1.6341465772719983 21.187928225994213 -6.904223050485102 0.9342078092719241 0.9763207040115116 1.7075908795885484 0.9885519314936032 0.03217861978803359 0.10836289665762765 0.1604177328900794 0.025614525893462223 0.06817186455116925 1.2467430316361893e-07 6.904223050485102 0.7312701755770368 EILAELTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EILAELTGR 9 0 P08559;P08559-4;P08559-3;P08559-2;Q5JPU0;Q5JPT9;Q5JPU1 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 0 6918200.0 2021600.0 1109700.0 3786900.0 False True 1957425.4145678924 1552808.997009052 2794997.2854351657 1.0 0.7932915274587048 1.4278946541889923 20.900525905661404 -6.819012843745192 1.3763859907370364 0.8884749442967032 1.441429612041944 0.8820395097849414 0.09076421354832169 0.19477214876331322 0.7253381767869499 0.05182689454671859 0.11947091359997303 1.5170055031539854e-07 6.819012843745192 0.5529546677452409 EILGTAQSVGCNVDGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EILGTAQSVGCNVDGR 16 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 56422600.0 7959600.0 31084000.0 17379000.0 False True 10435112.680876052 26446388.364482973 15580787.791139483 1.0 2.5343653847600556 1.493111600001567 23.314942843364136 -10.503279504128464 5.485983999187603 0.9980905000293689 2.013738492380345 0.5582643386190855 0.425090077566688 0.009940888418535073 0.0009000820195760361 0.412125317330776 0.1371972325878156 3.138488169141986e-11 10.503279504128464 1.015647992350976 EILGTAQSVGCNVDGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EILGTAQSVGCNVDGR 16 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 16240700.0 7292400.0 1730700.0 7217600.0 False True 7060906.753657945 2421777.535481271 5327094.036641273 1.0 0.34298392826483004 0.7544489996106434 22.751422033982845 -9.244396188398872 9.833222764619755 1.0000001408526011 0.5487166236830974 0.6159576671944971 0.16797991196269693 0.0 0.0 0.16264585038223991 0.054215283460746624 5.696443728235549e-10 9.244396188398872 -0.45128351716950377 EILGTAQSVGCNVDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EILGTAQSVGCNVDGR 16 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 66056600.0 7959600.0 29401000.0 28696000.0 False True 10902479.22010207 28101966.603894595 21918595.812671285 1.0 2.5775758005647 2.010423076272195 23.378152904887028 -9.813473807471398 5.889833004602022 0.9999998671995737 2.2939994384215483 0.8740674289196984 0.23153913013534796 4.040714718710086e-07 8.110792536355633e-08 0.22418682213131094 0.07472893291585352 1.5364774563007261e-10 9.813473807471398 1.2939995712219745 EILGTAQSVGCNVDGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EILGTAQSVGCNVDGR 16 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 9512600.0 7292400.0 0.0 2220200.0 False True 6063953.708096192 0.0 2684433.554955054 1.0 0.0 0.44268701315628034 22.53182730941712 -10.390818422121171 5.618906805126894 1.0002940433731387 0.22134350657814067 0.8048827640803143 0.1807262163316168 0.0006659532939940287 7.21996171921093e-05 0.17505092718678622 0.05832913550628417 4.0661329804777766e-11 10.390818422121171 -0.778950536794998 EILIPVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EILIPVFK 8 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 9035400.0 1326700.0 3625100.0 4083600.0 False True 1739316.5477810772 3084249.210529128 3661068.244657191 1.0 1.7732535313734816 2.10488898603752 20.730089089866556 -10.226949785888465 0.19270645257550884 3.2762561798560755e-18 2.413623015780621 0.9994475614902344 0.010880555211816757 1.8356733717736748 0.09338204022371199 1.1308102074273516 0.21192482050931452 5.929938839122294e-11 10.226949785888465 2.413623015780621 EILIPVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EILIPVFK 8 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 7037500.0 2999100.0 1466200.0 2572200.0 False True 2903895.2121243435 2051661.3061319918 1898463.655654053 1.0 0.7065204341967628 0.6537645186808351 21.469557963540705 -13.999999999999998 0.24137570906794636 2.9555837024454843 0.6307412301491275 0.9995272625048125 0.0033116581998752052 13.672381113919794 0.15549076244133347 12.898120594031756 0.025571793165426085 1.0000000000000041e-14 13.999999999999998 -2.324842472296357 EILIPVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EILIPVFK 8 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 13158100.0 1326700.0 6498100.0 5333300.0 False True 1817216.8427194105 6210992.455656863 4073684.3827613597 1.0 3.417859833591625 2.241716171123097 20.793299151389448 -10.232954102261774 10.750027603278426 0.9999999896156543 2.8297880023573607 0.7634341544287874 0.48015863954268334 1.2050622069476955e-07 8.377689559341046e-09 0.46491160015771316 0.15497053454053517 5.848518900427097e-11 10.232954102261774 1.8297880127417065 EILK(ub)QIEYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EILKQIEYR 9 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 117338000.0 40523000.0 40146000.0 36669000.0 True False 53126045.42529029 34156373.2878823 32874843.633885413 1.0 0.6429308452087871 0.6188084087703537 25.662915990279444 -13.999999999999998 0.38283486574924874 6.3938575586690005 0.6167934541592841 0.9998120480829217 0.0023894064269875605 24.39673222873284 0.20206035967729538 108.58000510889215 0.006482977967916526 1.0000000000000041e-14 13.999999999999998 -5.777064104509717 EILK(ub)QIEYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EILKQIEYR 9 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 154709000.0 48442000.0 57412000.0 48855000.0 True False 46904235.22581019 80336910.99962476 36058409.8814162 1.0 1.7127858627874488 0.7687666094078897 25.48321486122526 -6.704740413578363 1.8139389208365724 1.4405407054492037 0.7713091675600394 0.4401003114505624 0.3006232472224617 0.38574820446636804 2.470752948107012 0.13205368990517907 0.3376373477746769 1.973602044700076e-07 6.704740413578363 -0.6692315378891642 EILK(ub)QIEYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EILKQIEYR 9 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 173620000.0 67715000.0 48768000.0 57137000.0 True False 102728605.62961052 40064969.37387689 45843846.90596332 1.0 0.39000791579252736 0.4462617459371927 26.61426272706048 -10.790086612342671 10.903877437974591 1.002991937428528 0.418134831820238 0.9930387543118601 0.022965529988604162 0.001669534886147561 3.214058517952906e-05 0.02222518934981513 0.007412092931890916 1.6214866883088967e-11 10.790086612342671 -0.5848571056082901 EILK(ub)QIEYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EILKQIEYR 9 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 132770000.0 40523000.0 45213000.0 47034000.0 True False 55505448.1928987 43215340.160602964 35925537.8956364 1.0 0.7785783480283992 0.6472434520442747 25.726126051802336 -13.718849230992888 0.05678669720847018 2.426664531999566 8.136191247630178e-08 0.999965294557129 0.0008575481482446005 11.313152922779237 0.057067649408549276 2.440903535732459 0.5895333416404223 1.9105163953982118e-14 13.718849230992888 -2.4266644506376536 EILK(ub)QIEYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EILKQIEYR 9 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 152528320.0 48442000.0 72667000.0 31419320.0 True False 40281669.34446763 72275528.4477298 37988954.545478076 1.0 1.7942535556227206 0.9430829249060294 25.263620136659537 -6.661755690387717 1.9669291315309254 1.5105151314424596 0.9466383095812502 0.24302326789185558 0.3380344586000182 0.4802683377100241 3.573774193418038 0.13876843737309327 0.3747415149538091 2.1789351738421737e-07 6.661755690387717 -0.5638768218612095 EILK(ub)QIEYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EILKQIEYR 9 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 163358000.0 67715000.0 51880000.0 43763000.0 True False 87658402.36220367 48992832.393814825 35798583.04629986 1.0 0.5589062893409454 0.4083873545673404 26.38538904915293 -13.999999999999998 0.15007361856156326 3.1331136553907024 0.24292673339957657 0.9995659940664782 0.005230028401570631 11.957980396478145 0.1220086148358509 7.438142736143438 0.14914714575237636 1.0000000000000041e-14 13.999999999999998 -2.890186921991126 EILSNLGSPVVLCHNDLLCK(ub)NIIYNEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EILSNLGSPVVLCHNDLLCKNIIYNEK 27 1 A0A5K1VW28;H0YH69;Q9HBU6 A0A5K1VW28 ETNK1 Ethanolamine kinase 1 1 209171000.0 12995000.0 63816000.0 132360000.0 True False 19714365.061755713 52427536.20331623 106198987.98455106 1.0 2.659357074858142 5.38688350610736 24.232743910695447 -6.963692059678426 0.37983111203369235 0.8122891450966139 7.330377973904094 0.9998835938882336 0.019512724611744556 0.07840763702930863 0.016442406712164834 0.03550227803283247 0.23049211024678862 1.087196236432116e-07 6.963692059678426 6.51808882880748 EILSNLGSPVVLCHNDLLCK(ub)NIIYNEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EILSNLGSPVVLCHNDLLCKNIIYNEK 27 1 A0A5K1VW28;H0YH69;Q9HBU6 A0A5K1VW28 ETNK1 Ethanolamine kinase 1 1 175096000.0 12995000.0 47011000.0 115090000.0 True False 16822283.66974579 44394796.52400975 94144800.92312324 1.0 2.639046956737035 5.59643403781372 24.003870232787897 -6.962007221284277 0.4061558894387037 0.848065635324518 7.496483116012636 0.9998375521221116 0.024242463258133114 0.07899173595869438 0.01853820669659617 0.038052586104530724 0.2472358739181475 1.0914221885427998e-07 6.962007221284277 6.648417480688119 EILTELEAK(ub)SETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EILTELEAKSETR 13 1 Q6UWE0;Q6UWE0-2;Q6UWE0-3 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 1 12332200.0 4609200.0 3550400.0 4172600.0 True False 4462883.468948526 4968093.23509141 3079670.884683193 1.0 1.113202544869923 0.6900630290059481 22.08954470596885 -6.83550282522701 1.302983332777864 1.060300640916999 0.6773288927973257 0.9164615766419271 0.051696352569492524 0.1741197372496435 0.5761433375231161 0.031130584499993685 0.07166054335472753 1.4604852484786564e-07 6.83550282522701 -0.3829717481196734 EILTK(ub)ESNVQEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EILTKESNVQEVR 13 1 P67775;P67775-2;E7ESG8;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 31785200.0 13197700.0 11828000.0 6759500.0 True False 17302312.506708596 10063308.505182894 6060091.781702488 1.0 0.5816163880568603 0.350247504739775 24.04446153554181 -9.529318471743318 0.1536232526303828 1.5938433104973875 3.5319402592204596e-12 0.9997690591168464 0.004086367144767639 0.9744808514515234 0.06115353300957031 0.4350069472342071 0.18351509146475975 2.955844126619723e-10 9.529318471743318 -1.5938433104938556 EILTK(ub)ESNVQEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EILTKESNVQEVR 13 1 P67775;P67775-2;E7ESG8;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 54142100.0 20090500.0 17126600.0 16925000.0 True False 19452738.0744837 23965340.694039144 12491834.760883605 1.0 1.2319777607798388 0.6421633146476813 24.213469900577763 -6.800025705959861 1.455926738831873 1.1279880974382526 0.6340271251413595 0.8322054003790841 0.09938020277800197 0.22072153486839474 0.9237041698007663 0.05370046406869026 0.12487888538588915 1.5847993851557674e-07 6.800025705959861 -0.49396097229689306 EILTK(ub)ESNVQEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EILTKESNVQEVR 13 1 P67775;P67775-2;E7ESG8;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 89500300.0 29002300.0 21753000.0 38745000.0 True False 43998609.45213988 17871007.193035264 31087033.767463204 1.0 0.40617209079015804 0.7065458239374264 25.390954593229587 -10.535298355516339 6.431852437821503 1.0004551340339782 0.5563589573638182 0.7441514033592624 0.12262706305762089 0.0008011043065694511 5.787958932170739e-05 0.1188495309771191 0.03957771441804104 2.915423462126108e-11 10.535298355516339 -0.44409617667016 EILTK(ub)ESNVQEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EILTKESNVQEVR 13 1 P67775;P67775-2;E7ESG8;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 32505500.0 13197700.0 8347800.0 10960000.0 True False 18077246.344432 7978966.59351693 8371473.728285389 1.0 0.4413817481651205 0.46309452052490835 24.1076715970647 -10.439245623309054 6.985816304363169 1.0000662615961866 0.4522381343450732 0.9988229445349288 0.008864202197114413 9.149040285030118e-06 7.343977518898171e-07 0.008583755353197322 0.0028609089572366074 3.63709275412034e-11 10.439245623309054 -0.5478281272511134 EILTK(ub)ESNVQEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EILTKESNVQEVR 13 1 P67775;P67775-2;E7ESG8;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 54453200.0 20090500.0 22692200.0 11670500.0 True False 16706140.91005794 22569952.61455094 14110747.591704782 1.0 1.3509973809069629 0.8446443536944789 23.99387517601204 -6.720260814978626 1.758238903420789 1.2134892428197108 0.8454177766606821 0.5137047418176945 0.14769750470123774 0.35486512731721415 2.1440720838537013 0.06669351159506957 0.1673830343999023 1.9043167395825647e-07 6.720260814978626 -0.36807146615902875 EILTK(ub)ESNVQEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EILTKESNVQEVR 13 1 P67775;P67775-2;E7ESG8;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 85267600.0 29002300.0 22344200.0 33921100.0 True False 37544049.07080172 21100725.627869632 27747807.859878004 1.0 0.56202583765212 0.7390733963603748 25.162080915322036 -10.151542407201951 5.2849515728846805 1.000011463790248 0.6505496170060738 0.8385621497676816 0.07227936317405295 9.763326378866075e-06 1.567641569448541e-06 0.06998648642112942 0.023328064153877778 7.054359575531716e-11 10.151542407201951 -0.34946184678417413 EILTLLQGVHQGAGFQDIPK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 EILTLLQGVHQGAGFQDIPKR 21 1 E9PGT1;Q15631;H7C1D4;Q15631-2 E9PGT1 TSN Translin 1 8878500.0 1446700.0 5759600.0 1672200.0 True False 1896637.70986273 4900290.130744965 1499176.7848750476 1.0 2.5836722033221755 0.7904391951500064 20.8550126950419 -6.67356017365458 1.9245840990263992 2.0077269690343025 0.7975353368687254 0.29499635765807986 0.6721600088620487 0.4529873599216236 3.238041786787148 0.2808175743859276 0.7468544114496707 2.1205075658939275e-07 6.67356017365458 -1.2101916321655772 EILTLLQGVHQGAGFQDIPK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 EILTLLQGVHQGAGFQDIPKR 21 1 E9PGT1;Q15631;H7C1D4;Q15631-2 E9PGT1 TSN Translin 1 42655000.0 18528100.0 12192700.0 11934200.0 True False 17939935.607269205 17061308.69409053 8808275.001674276 1.0 0.9510239650568948 0.49098699095136056 24.096671376138715 -6.927239638444969 0.7691254398297355 1.007758935385144 0.40286056752736793 0.9959670252762841 0.014560634075558387 0.0940972057670827 0.08489330741722079 0.013053660954188938 0.04227502527475741 1.182388947763544e-07 6.927239638444969 -0.604898367857776 down EILTLLQGVHQGAGFQDIPK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 EILTLLQGVHQGAGFQDIPKR 21 1 E9PGT1;Q15631;H7C1D4;Q15631-2 E9PGT1 TSN Translin 1 26435200.0 5856900.0 11335000.0 9243300.0 True False 8885345.496744681 9312180.689240774 7416357.703517684 1.0 1.0480381086647077 0.8346729686802624 23.082996444255595 -6.847564948508951 1.2467462306063528 1.0255912079168497 0.8265339227829076 0.9366949338356689 0.022993594393792432 0.16015276439625448 0.48026181850774247 0.014440064613146513 0.03336808145629092 1.4204797649809452e-07 6.847564948508951 -0.19905728513394205 EILTLLQGVHQGAGFQDIPK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EILTLLQGVHQGAGFQDIPKR 21 1 E9PGT1;Q15631;H7C1D4;Q15631-2 E9PGT1 TSN Translin 1 6161300.0 1446700.0 4714600.0 0.0 True False 1981584.0855974753 4506293.382902675 0.0 1.0 2.2740863815243877 0.0 20.91822275656479 -6.757545090493431 1.6404520679996555 1.7448370625279066 5.331628536187812e-10 0.6686982741519268 0.53566356456932 0.2897746781203931 1.5394928371072718 0.25854445900257755 0.6182497583591559 1.7476518035776944e-07 6.757545090493431 -1.7448370619947438 EILTLLQGVHQGAGFQDIPK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EILTLLQGVHQGAGFQDIPKR 21 1 E9PGT1;Q15631;H7C1D4;Q15631-2 E9PGT1 TSN Translin 1 44932600.0 5856900.0 30253000.0 8822700.0 True False 7581872.506759076 28569393.955475662 7217059.128546696 1.0 3.768118486562081 0.9518834723365294 22.854122766348045 -6.650062694478391 2.007943921303663 2.7960637623800064 0.9635948183793402 0.19454085296738477 1.181426659619538 0.5083028052042212 3.928181559796169 0.47712511196901936 1.3088862413151066 2.2383979815180676e-07 6.650062694478391 -1.832468944000666 EILVGDVGQTVDDPYATFVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EILVGDVGQTVDDPYATFVK 20 0 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 63557000.0 10655000.0 31753000.0 21149000.0 False True 13968808.183166768 27015576.17222459 18960704.355533093 1.0 1.9339929232316282 1.3573602061757746 23.735705599663024 -10.086972309003565 5.2904467969871805 0.9999904585941422 1.6456765647043843 0.6257128862700492 0.23540932096598316 35306202.65784708 67316184.49248593 2754.050702584788 0.08058687293405943 8.185169758300787e-11 10.086972309003565 0.6456861061102421 EILVGDVGQTVDDPYATFVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EILVGDVGQTVDDPYATFVK 20 0 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 264659000.0 75596000.0 43263000.0 145800000.0 False True 73196246.35915825 60538141.51356454 107610606.09375666 1.0 0.8270662025005612 1.4701656361684798 26.125266330509376 -6.835125142543712 1.3048582065055618 0.907870785741164 1.4893541323500679 0.9157395403195274 0.07887707490653167 0.17457111676874842 0.5794745491222496 0.047434588597902 0.10917740074490657 1.4617559068190336e-07 6.835125142543712 0.5814833466089039 EILVGDVGQTVDDPYATFVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EILVGDVGQTVDDPYATFVK 20 0 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 81240000.0 10655000.0 28293000.0 42292000.0 False True 14594441.440548196 27042921.70756062 32303500.631080806 1.0 1.8529603765736742 2.2134112334940736 23.798915661185916 -10.108410050015785 0.20289398666786182 2.600153695536111e-18 2.5221591556196064 0.999390831326609 0.012557693551201121 1.6568157531398056 0.09532647213467739 1.110431471569404 0.21362941992463405 7.790941618736078e-11 10.108410050015785 2.5221591556196064 EILVGDVGQTVDDPYATFVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EILVGDVGQTVDDPYATFVK 20 0 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 121425000.0 75596000.0 22801000.0 23028000.0 False True 62861423.470632344 22678166.48735587 27843048.33055804 1.0 0.3607644439988012 0.4429274234231393 25.905671605943652 -10.647153365227558 6.640453614482087 1.0027148844370073 0.40184593371230043 0.9860464443876198 0.033542895889403575 0.001351975677644804 7.18383854415385e-05 0.03256893498517818 0.010825923096935771 2.25344329857807e-11 10.647153365227558 -0.6008689507247069 EILVGDVGQTVDDPYATFVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EILVGDVGQTVDDPYATFVK 20 0 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 26619100.0 4921600.0 13168000.0 8529500.0 False True 6371108.219239777 12435189.224397695 6977218.520060644 1.0 1.9518094492329163 1.0951342027106847 22.603112912502798 -10.30686796709905 4.11159574486754 0.9992614646586251 1.5234718259817273 0.33237355131221225 0.34973620494604735 34106009.861784354 85498862.93534648 137893.84110948833 0.1197240123086021 4.933237599635525e-11 10.30686796709905 0.5242103613231022 EILVGDVGQTVDDPYATFVK(ub)MLPDKDCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EILVGDVGQTVDDPYATFVKMLPDKDCR 28 2 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 1 17733610.0 14512000.0 838410.0 2383200.0 True False 14051324.50346717 1173191.4852503918 1758968.4255325145 1.0 0.08349330235458631 0.12518168127840817 23.744202792132512 -10.129385682293469 5.357025338746517 1.0000192424015872 0.10433749181614412 0.9983778258933786 0.01701920942959954 3.947425301049241e-06 6.415472664373362e-07 0.01647913498113574 0.005492926223618002 7.423595805490711e-11 10.129385682293469 -0.8956817505854431 EILVGDVGQTVDDPYATFVK(ub)MLPDKDCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EILVGDVGQTVDDPYATFVKMLPDKDCR 28 2 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 1 22835900.0 14512000.0 2715900.0 5608000.0 True False 12067370.990605539 2701268.907636058 6780606.8715376705 1.0 0.22384899823988164 0.5618959487378303 23.52460806756679 -10.584086806115197 6.43881600633454 1.001274357835896 0.3928724734998343 0.8113475707602597 0.13800708963730968 0.0025290402467504883 0.00016336218577394255 0.13385731992461053 0.04454159665198786 2.605632688079265e-11 10.584086806115197 -0.6084018843360617 EILVGDVGQTVDDPYATFVK(ub)MLPDKDCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EILVGDVGQTVDDPYATFVKMLPDKDCR 28 2 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 1 95376100.0 21817000.0 28311100.0 45248000.0 True False 28242536.5773639 26735562.397543006 37013328.28368655 1.0 0.9466416844077412 1.3105525483625413 24.75136633296373 -6.869635303846643 1.1359594847260484 0.9698850667067621 1.3317235858431626 0.964321148618612 0.03030867647898006 0.1372083747550328 0.3311328075007277 0.020710414046005668 0.04900429548367078 1.3500961417361162e-07 6.869635303846643 0.3618385191364005 EILVK(ub)ELTTSSPEGCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EILVKELTTSSPEGCR 16 1 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 1 27739600.0 7411100.0 5581500.0 14747000.0 True False 11243180.523984445 4585437.716541457 11832248.986160284 1.0 0.40784168739082327 1.0523934006857945 23.42254687389018 -12.079522635971069 18.82045281862859 0.9147830469070888 0.7571057896344793 0.0 0.2989859438087068 0.0 0.0 0.0 0.08708562502879351 8.326785246090094e-13 12.079522635971069 -0.1576772572726095 EILVK(ub)ELTTSSPEGCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EILVKELTTSSPEGCR 16 1 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 1 8471100.0 3624200.0 1483500.0 3363400.0 True False 3013682.8792828447 1475508.0910483063 4066671.3893954656 1.0 0.4896029709003184 1.3494025590254528 21.52309618381921 -6.74589229173522 1.6650840139001257 0.6984031240646121 1.3505854915341429 0.631078281861905 0.21444297402522955 0.30727260368632014 1.6748067173587493 0.10179533972264693 0.24820324206222866 1.7951787893330716e-07 6.74589229173522 0.6521823674695307 EILVK(ub)ELTTSSPEGCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EILVKELTTSSPEGCR 16 1 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 1 28262300.0 7411100.0 7508200.0 13343000.0 True False 9593815.044621248 7090362.069761756 10914710.91074146 1.0 0.7390555307543637 1.13768202325943 23.19367319598263 -6.7300758990262315 1.722756059741095 0.8429789746834393 1.1374564763932014 0.5596864540120532 0.10969439811269989 0.3361053548486825 1.9542388845345733 0.050456071308030016 0.12520200292401173 1.861761739363821e-07 6.7300758990262315 0.29447750170976206 EINCK(ub)CLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EINCKCLK 8 1 Q4VXH1;Q9UKT8;Q9UKT8-2 Q4VXH1 FBXW2 F-box/WD repeat-containing protein 2 1 1766260.0 378170.0 500130.0 887960.0 True False 517989.6686599828 478032.6028912553 678242.1361102455 1.0 0.9228612688896002 1.3093738681407083 18.982563797982525 -6.85481683661556 1.211581000131656 0.9585973441390393 1.326325828591334 0.9470300530788247 0.03843948580286355 0.15223791900831796 0.42762085889227663 0.02479151306035611 0.05757599326076138 1.396957402610057e-07 6.85481683661556 0.36772848445229467 EINQK(ub)YGCNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EINQKYGCNR 10 1 A0A087WXL3;O75417 A0A087WXL3 POLQ DNA polymerase theta 1 4686730.0 561040.0 804890.0 3320800.0 True False 851138.6975180776 661251.0908657269 2664442.4244416547 1.0 0.7769016880491236 3.130444464822449 19.699034720234184 -6.883672175469769 1.059150175344243 0.8537004175979216 3.3094139338167925 0.9765270571723625 0.16252440116575279 0.12442508407529736 0.2530741911126611 0.1177901103014915 0.2876884077161017 1.3071572154430476e-07 6.883672175469769 2.455713516218871 up EINQK(ub)YGCNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EINQKYGCNR 10 1 A0A087WXL3;O75417 A0A087WXL3 POLQ DNA polymerase theta 1 2146570.0 501350.0 623520.0 1021700.0 True False 686712.6434743162 595970.8246950911 780395.5025720063 1.0 0.8678605678204336 1.1364222138443762 19.38934700061131 -6.772958401259899 1.5635371927382062 0.9244935697377156 1.1380896509292722 0.7415965114352052 0.05573602036537633 0.2616769098363255 1.2629404993637552 0.028093711472230908 0.06668370818018274 1.6867145789982222e-07 6.772958401259899 0.2135960811915566 EINQK(ub)YGCNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EINQKYGCNR 10 1 A0A087WXL3;O75417 A0A087WXL3 POLQ DNA polymerase theta 1 1802920.0 410350.0 621070.0 771500.0 True False 341224.2065873066 617724.1726372573 932817.0829870391 1.0 1.8103175586964246 2.7337365432436456 18.38036047011036 -6.96942181574834 0.27164014045972046 0.774961018990849 3.7969148925999945 0.9999775154825861 0.0033585857464706924 0.07649076058717039 0.00969953848133568 0.017921116619380017 0.08569082081729248 1.0729467886529377e-07 6.96942181574834 3.0219538736091454 EINQK(ub)YGCNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EINQKYGCNR 10 1 A0A087WXL3;O75417 A0A087WXL3 POLQ DNA polymerase theta 1 4259600.0 561040.0 683360.0 3015200.0 True False 726277.3397517639 645330.4152782827 2466464.5385646117 1.0 0.8885454356855631 3.3960367528575666 19.470161042326634 -6.896499420919902 0.9831480712871011 0.8855002004784644 3.6412904010946257 0.9847423134848526 0.14287394926541117 0.11402755366230871 0.1923143368931621 0.10967191793973594 0.2806474561707856 1.2691138366565945e-07 6.896499420919902 2.755790200616161 up EINTILK(ub)AQHPNIVTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EINTILKAQHPNIVTVR 17 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 30830300.0 3546700.0 4393600.0 22890000.0 True False 5380603.198501651 3609527.752646522 18365781.46695659 1.0 0.6708407253766038 3.413331329110266 22.35933648610348 -6.87692528134014 1.0968609620581085 0.8032416039770779 3.596541468879235 0.9711169122147472 0.20778899032090378 0.1303857739920965 0.2890735496342437 0.1463162242024608 0.35120985356623796 1.3276228503791342e-07 6.87692528134014 2.793299864902157 up EINTILK(ub)AQHPNIVTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EINTILKAQHPNIVTVR 17 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 5132000.0 0.0 2449700.0 2682300.0 True False 0.0 2341464.1539253998 2048795.9837025453 0.0 EINTILK(ub)AQHPNIVTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EINTILKAQHPNIVTVR 17 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 65275800.0 3546700.0 4145100.0 57584000.0 True False 4591273.065908993 3914421.5411642594 47104302.8617355 1.0 0.8525786824202476 10.25952980481453 22.13046280819593 -6.903343402608988 0.9399165688364577 0.6439574479905378 11.316725616422355 0.9881568001685097 0.47885205485748344 0.10898507761697203 0.16387656909260095 0.37957212857435574 1.0051919947062755 1.2492708239841367e-07 6.903343402608988 10.672768168431817 up EIPAK(ub)IIFEDDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIPAKIIFEDDR 12 1 P49773;D6REP8;D6RE99;D6RD60;D6RC06 P49773 HINT1 Histidine triad nucleotide-binding protein 1 1 21198500.0 4126100.0 10484000.0 6588400.0 True False 6259595.358315528 8613048.288134122 5286199.8522017 1.0 1.3759752500123128 0.8444954585090352 22.57763796874729 -6.716640161220014 1.771224458754852 1.229550604743452 0.8454650574777649 0.4967233846796748 0.15827994384125638 0.36187378059864744 2.2168008753641506 0.07100316460363701 0.17896491146190344 1.920259130486582e-07 6.716640161220014 -0.384085547265687 EIPAK(ub)IIFEDDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIPAKIIFEDDR 12 1 P49773;D6REP8;D6RE99;D6RD60;D6RC06 P49773 HINT1 Histidine triad nucleotide-binding protein 1 1 16318140.0 2543100.0 12851100.0 923940.0 True False 2114700.3284322624 12781868.573556378 1117131.5821841138 1.0 6.044293085740542 0.5282694513091137 21.012021804623995 -6.6661616985002246 1.95111386186316 4.230395547545104 0.5510244741859894 0.2620377833076495 2.14463692086293 0.4700376267415117 3.445955636165025 0.8861065992914505 2.379251413400109 2.1569411774639064e-07 6.6661616985002246 -3.6793710733591145 EIPAK(ub)IIFEDDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIPAKIIFEDDR 12 1 P49773;D6REP8;D6RE99;D6RD60;D6RC06 P49773 HINT1 Histidine triad nucleotide-binding protein 1 1 29794900.0 4126100.0 7013400.0 18655400.0 True False 5341317.787590468 6623098.124725919 15260308.620568551 1.0 1.23997455087084 2.8570306481338674 22.34876429083974 -6.933431965979994 0.718069261683501 0.9782641644733732 3.2200026476112327 0.9971707108230214 0.043866132553566264 0.09089462641227165 0.06923619488510187 0.04081363918759112 0.14365465589010393 1.16564964035409e-07 6.933431965979994 2.2417384831378593 up EIPLAK(ub)DFYVAFQDLPTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIPLAKDFYVAFQDLPTR 18 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 25932400.0 4597400.0 2562000.0 18773000.0 True False 5951424.928302363 2419422.4478209997 15356506.627246436 1.0 0.4065282645699334 2.5803075418489505 22.50480369839634 -6.833943695994447 1.3101335123335638 0.6836492220311466 2.643688706892068 0.9135528246504303 0.2697382366262552 0.17598710265129047 0.5893566233321434 0.16158163092903022 0.3718804430359968 1.4657378538765062e-07 6.833943695994447 1.9600394848609213 up EIQEAK(ub)APSPSINR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIQEAKAPSPSINR 14 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 8049280.0 3686780.0 2972400.0 1390100.0 True False 3569745.1869413387 4159294.82086123 1025991.1078939044 1.0 1.1651517413838255 0.28741298164561807 21.76738966580368 -6.858044410351262 1.1956185902065553 1.0891767392053442 0.24647735801612866 0.9512151925475517 0.08412135655040286 0.14882891640818652 0.40539252542872806 0.05491871632930756 0.127924158841446 1.386614028394833e-07 6.858044410351262 -0.8426993811892155 down EIQEAK(ub)APSPSINR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIQEAKAPSPSINR 14 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 12486640.0 3686780.0 8154300.0 645560.0 True False 3065720.922046906 8110371.1673981855 780543.6112678065 1.0 2.645502109821233 0.25460360910694274 21.547794941237957 -6.721516319925126 1.7539890623080703 1.99947658489189 0.25804033182034186 0.5196283850235479 0.6923059311856135 0.352368678789177 2.1194268602727973 0.3133112257751938 0.7850905285805687 1.8988194868910233e-07 6.721516319925126 -1.7414362530715481 EIQLEISGK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIQLEISGKER 11 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 20239700.0 5123100.0 8062100.0 7054500.0 True False 6716433.712170969 6859266.105819658 6324568.011542299 1.0 1.0212661063549038 0.941655688506452 22.679263964309527 -6.835617029516688 1.3024524522508156 1.0113275290337311 0.939254233073787 0.9166724505192073 0.009715115064499092 0.17398390425245513 0.5751781340939918 0.005852536722594693 0.013472413937429362 1.4601012423289112e-07 6.835617029516688 -0.07207329595994416 EIQLEISGK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIQLEISGKER 11 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 17171800.0 2080000.0 6167400.0 8924400.0 True False 2013971.5385344366 8630074.982566113 6586831.913738831 1.0 4.285102752170074 3.2705685198173438 20.941611864632446 -10.471371465339754 7.301192240540488 0.9996162203827278 3.7778356359936915 0.9090563483223859 0.41418186597506973 0.0025877161327924757 0.00018735581125390037 0.4010684875393183 0.13367662243521308 3.377758026496189e-11 10.471371465339754 2.778219415610964 EIQLEISGK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIQLEISGKER 11 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 41406700.0 7284900.0 17293100.0 16828700.0 True False 11051725.89752861 14207011.193393001 13502500.068718754 1.0 1.2855015881790897 1.221754881899323 23.397768350513665 -10.119902925733356 4.458052536631136 0.9999704119508361 1.2536282349986412 0.9547646536318725 0.026024483900883622 13720856.93764915 0.31296262976019396 4260.097066925279 0.009523985895189303 7.587471525747396e-11 10.119902925733356 0.25365782304780504 EIQLEISGK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIQLEISGKER 11 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 16925300.0 5123100.0 7275700.0 4526500.0 True False 7017248.516571794 6954235.51647754 3457433.926193782 1.0 0.9910202695621448 0.4927050706596432 22.74247402583242 -6.910807015000618 0.8902234206751375 1.0150378087220222 0.4271825510379426 0.9912225122564445 0.02220907272576826 0.10388672400995547 0.1358912981814294 0.018255729897366044 0.05068019959761877 1.227984782637569e-07 6.910807015000618 -0.5878552576840796 down EIQLEISGK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIQLEISGKER 11 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 19338700.0 2080000.0 13123800.0 4134900.0 True False 1729612.1596237284 13053099.484529674 4999488.472382506 1.0 7.546836099585085 2.890525742759654 20.722017140066722 -9.751967466319917 8.356659629655944 0.9999999347768715 5.21868092117237 0.5225547685597405 1.9009307430431666 1.1249670300163971e-08 0.0 1.8405682775249665 0.6135227591749888 1.770241564919683e-10 9.751967466319917 4.218680986395499 EIQLEISGK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIQLEISGKER 11 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 43179600.0 7284900.0 17390900.0 18503800.0 True False 9430446.65684734 16423081.127170272 15136298.265021212 1.0 1.7414955754238493 1.6050457434092922 23.168894672606115 -10.086121168557058 4.383330012927629 0.9999345797631787 1.673270659471417 0.970115142580709 0.05570541085430941 8126620.393926832 6233169.592365132 4577.339574542009 0.019069443620245385 8.20122697425519e-11 10.086121168557058 0.6733360797082384 EIQMAVLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIQMAVLLK 9 0 K7ENR6;Q969U7-2;Q969U7 K7ENR6 PSMG2 Proteasome assembly chaperone 2 0 9293000.0 2203500.0 4699700.0 2389800.0 False True 2852474.1874786303 4438157.563631674 1954880.921418719 1.0 1.555897537342719 0.6853281722933607 21.443782400705768 -6.7342606433874055 1.7081647297029643 1.3329473850263376 0.6854747937075251 0.5787117790115326 0.23361725260162988 0.32830051615448214 1.878594925040227 0.10830874385042208 0.26742599928040184 1.843908458779748e-07 6.7342606433874055 -0.6474725913188125 EIQTAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIQTAVR 7 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 310600000.0 10790000.0 169980000.0 129830000.0 False True 14145794.490508623 144619646.57685053 116396437.017299 1.0 10.223508242954166 8.228342147582964 23.753869871368337 -9.310155238619677 8.59009423475938 0.9999932298628187 9.225925195273918 0.9577429823895804 0.8145231476548287 0.0 0.0 0.7886586464792651 0.2628862154930883 4.89603779150983e-10 9.310155238619677 8.2259319654111 EIQTAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIQTAVR 7 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 184306000.0 72344000.0 30021000.0 81941000.0 False True 70047479.31910346 42008541.85744681 60478193.92269215 1.0 0.5997152540789598 0.863388583152034 26.06182979996028 -10.29333812168742 6.152091934217472 1.0000120617803114 0.7315519186154967 0.5801953163733634 0.10764418583499902 1.7809254789744667e-05 2.0457773317821244e-06 0.1042307144094275 0.03474201158791717 5.089344838165255e-11 10.29333812168742 -0.2684601431648147 EIQTAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIQTAVR 7 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 376390500.0 4316300.0 364190000.0 7884200.0 False True 6548142.66379809 299197449.07054263 6325884.414232379 1.0 45.69195639622801 0.966057818074966 22.642654323346367 -6.24085582610589 22.991125166250324 9.999999999999998 0.9660332493968633 0.0 21.251790131580634 1783.4486555695435 4483583.474976044 9.078853997568439 71.76573981126529 5.743070848150745e-07 6.24085582610589 -9.033966750603135 EIQTAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIQTAVR 7 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 249780000.0 10790000.0 123520000.0 115470000.0 False True 14779354.588786015 118062477.97398263 88198364.17929862 1.0 7.988337871233141 5.967673598292311 23.81707993289123 -9.697205577400085 7.382772046866858 1.0000008605688526 6.978005734762795 0.9210720976666832 0.8249327350303687 1.4728514933837773e-08 6.448591238034894e-09 0.7987377099323169 0.266245895376033 2.0081420145784772e-10 9.697205577400085 5.978004874193942 EIQTAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIQTAVR 7 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 79554100.0 72344000.0 4290500.0 2919600.0 False True 60157241.38260527 4267386.224902431 3530074.861294822 1.0 0.07093719935994877 0.058680796861066815 25.842235075394555 EIQTAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIQTAVR 7 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 15417400.0 4316300.0 6098400.0 5002700.0 False True 5587535.436992978 5759018.679075554 4092259.9320367496 1.0 1.0306903184805325 0.7323908686007484 22.413780645438816 -6.881521801972877 1.0712469140735132 1.0194340369587267 0.7106213492706357 0.9748935761828766 0.021228044689477386 0.1262918721246886 0.264197280422446 0.01524306223989849 0.03700925801282899 1.3136455471189737e-07 6.881521801972877 -0.308812687688091 EIQVQHPAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIQVQHPAAK 10 0 P49368;B4DUR8;E9PRC8;Q5SZX6;Q5SZX9 P49368 CCT3 T-complex protein 1 subunit gamma 0 12560150.0 517250.0 6787700.0 5255200.0 False True 678119.7590561258 5775001.618247372 4711442.315437956 1.0 8.51619723673233 6.947802733245537 19.37118055685297 -9.704818464537455 8.694562196417868 0.9999999999956531 7.731999984988934 0.9608839828285056 0.6402943748214062 0.0 0.0 0.6199623672074768 0.20665412086279902 1.9732473828344306e-10 9.704818464537455 6.731999984993281 EIQVQHPAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIQVQHPAAK 10 0 P49368;B4DUR8;E9PRC8;Q5SZX6;Q5SZX9 P49368 CCT3 T-complex protein 1 subunit gamma 0 11851140.0 3765800.0 2587640.0 5497700.0 False True 3646256.740294707 3620898.1463643303 4057687.442535293 1.0 0.993045307630113 1.1128364598394496 21.797984717346704 -6.89312636245585 1.0036857611251473 0.9940375538306891 1.12379429355469 0.982825682875076 0.007195253204746503 0.11664397105166699 0.20731485639188327 0.005438533346105298 0.013720472154039421 1.2790091091299155e-07 6.89312636245585 0.12975673972400092 EIQVQHPAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIQVQHPAAK 10 0 P49368;B4DUR8;E9PRC8;Q5SZX6;Q5SZX9 P49368 CCT3 T-complex protein 1 subunit gamma 0 11326250.0 517250.0 5305800.0 5503200.0 False True 708491.3031556606 5071372.21206571 4203457.501961694 1.0 7.157987951972775 5.932969795450212 19.43439061837586 -9.873867773645685 6.571987188305618 0.9999997797010897 6.545478873711799 0.9646932733899983 0.5001115681886252 1.610634462136613e-06 2.76679214479253e-07 0.48423097256646924 0.1614103145698565 1.3370025216242074e-10 9.873867773645685 5.54547909401071 EIQVQHPAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIQVQHPAAK 10 0 P49368;B4DUR8;E9PRC8;Q5SZX6;Q5SZX9 P49368 CCT3 T-complex protein 1 subunit gamma 0 6763440.0 3765800.0 2879100.0 118540.0 False True 3131429.553226464 2863589.7168433955 143326.16593296654 1.0 0.9144672323517226 0.0457702028727712 21.57838999278098 -7.055067561204576 0.913106656461177 1.004849563164162 4.018089207261933e-16 0.9932542612202048 0.035406027094852376 0.08066065459686526 0.121282722029415 0.030394983104527363 0.063928876127112 8.809118229282251e-08 7.055067561204576 -1.0048495631641616 down EIQVQHPAAK(ub)SMIEISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIQVQHPAAKSMIEISR 17 1 P49368;B4DUR8;E9PRC8;Q5SZX6;Q5SZX9 P49368 CCT3 T-complex protein 1 subunit gamma 1 38062800.0 7747800.0 16865000.0 13450000.0 True False 10157440.829801934 14348807.739255097 12058323.021510227 1.0 1.412640051729929 1.1871418424738547 23.276033624665356 -10.107940889105098 4.238134633513978 0.9999516163528213 1.299890947143869 0.7022207611537788 0.09205925857719155 13098579.143861573 10413362.525751324 5289.0781557305945 0.031514332629290646 7.799362587586447e-11 10.107940889105098 0.29993933079104784 EIQVQHPAAK(ub)SMIEISR ddPTM_RPMI8226_Bortezomib_2h_R1 2 EIQVQHPAAKSMIEISR 17 1 P49368;B4DUR8;E9PRC8;Q5SZX6;Q5SZX9 P49368 CCT3 T-complex protein 1 subunit gamma 1 83799080.0 13944080.0 29896600.0 39958400.0 True False 13501432.813003497 41834468.288709335 29492096.31369525 1.0 3.098520643558492 2.1843678905909027 23.686609182785915 -10.046158037905215 4.726780827724582 0.999957323904372 2.6414442670942826 0.8112802235592577 0.37320129879467295 129197748.35270797 7.884514052046634 71557.80500396491 0.12775673112377794 8.991703177543154e-11 10.046158037905215 1.6414869431899106 EIQVQHPAAK(ub)SMIEISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIQVQHPAAKSMIEISR 17 1 P49368;B4DUR8;E9PRC8;Q5SZX6;Q5SZX9 P49368 CCT3 T-complex protein 1 subunit gamma 1 213738000.0 22116000.0 59932000.0 131690000.0 True False 33551588.896174595 49236666.34914677 105661413.77822247 1.0 1.467491345983931 3.149222354422372 24.999877753687752 -6.9473141931779585 0.5875903115340853 0.9804176213138446 3.7205689448652732 0.9989733086098872 0.029572017445838865 0.08458248658535385 0.04056634167352369 0.030735050307676096 0.14078663686718546 1.1289788520334338e-07 6.9473141931779585 2.7401513235514288 up EIQVQHPAAK(ub)SMIEISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIQVQHPAAKSMIEISR 17 1 P49368;B4DUR8;E9PRC8;Q5SZX6;Q5SZX9 P49368 CCT3 T-complex protein 1 subunit gamma 1 42214800.0 7747800.0 10168000.0 24299000.0 True False 10612371.036422284 9718744.13892047 18560076.65361377 1.0 0.9157938509278619 1.7489095122960259 23.339243686188247 -6.882009378479842 1.0685799363048032 0.9462912607599892 1.810262788952255 0.9752683252205098 0.05889001904237052 0.12586276600832322 0.2616839907008647 0.042374800995150674 0.1030123466056797 1.3121715626991752e-07 6.882009378479842 0.8639715281922657 EIQVQHPAAK(ub)SMIEISR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 EIQVQHPAAKSMIEISR 17 1 P49368;B4DUR8;E9PRC8;Q5SZX6;Q5SZX9 P49368 CCT3 T-complex protein 1 subunit gamma 1 64788880.0 13944080.0 24685800.0 26159000.0 True False 11595120.347483676 24552812.69565237 31628725.95444969 1.0 2.117512536295556 2.727761765863312 23.46701445822019 -9.077706325508718 0.19564392554201523 3.444072241297026e-12 3.3896514039901864 0.9995863512624356 0.014550413804421186 0.5366919863388295 0.06710792282444668 0.6801722451366795 0.34392164399341435 8.361682528581282e-10 9.077706325508718 3.3896514039867425 EIQVQHPAAK(ub)SMIEISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIQVQHPAAKSMIEISR 17 1 P49368;B4DUR8;E9PRC8;Q5SZX6;Q5SZX9 P49368 CCT3 T-complex protein 1 subunit gamma 1 196627000.0 22116000.0 67971000.0 106540000.0 True False 28629597.97153501 64188354.09868893 87150813.19271496 1.0 2.242027784061384 3.0440809290917987 24.7710040757802 -8.38255049055709 0.1875976348207952 1.0064616705662395e-20 4.113260902167387 0.9997871540202146 0.012268259708171256 0.11554448997433907 0.04483074876428253 0.4293190552417128 0.40034602928783763 4.144284002869012e-09 8.38255049055709 4.113260902167387 EISAQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EISAQIR 7 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 6631500.0 2021900.0 1753200.0 2856400.0 False True 2650730.4801074504 1491629.3939200763 2560847.1285235574 1.0 0.5627239001151152 0.9660911012045821 21.337958557228465 -10.464881715674252 8.871693902532686 1.0000042145949197 0.7644075006598486 0.31264010152436583 0.16467397027396813 1.3727707632088977e-05 8.282270377563659e-07 0.1594477372465671 0.053148295368744485 3.428611554009826e-11 10.464881715674252 -0.2355967139350711 EISAQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EISAQIR 7 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 7089100.0 2021900.0 2160300.0 2906900.0 False True 2769451.069792998 2064850.8028432217 2220350.0894847456 1.0 0.7455812544821594 0.8017293079132484 21.401168618751356 -10.796847582893815 7.08423930346319 1.0082336047154634 0.7736552811980021 0.9558840939261873 0.022922346826115714 0.0030347359741044796 8.702600712014615e-05 0.022595473479680942 0.007398155626128044 1.596439324672541e-11 10.796847582893815 -0.23457832351746133 EISEGDEVEVYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EISEGDEVEVYSR 13 0 B4DXZ6;P51114;P51114-2;C9JAJ4 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 0 6005350.0 639550.0 1819800.0 3546000.0 False True 838456.2434110101 1548292.93352484 3179093.9356338475 1.0 1.8465995640107231 3.7916038679617294 19.677375970139217 -6.957246551692577 0.4726521446337631 0.9499289951466262 4.768365940111923 0.9996540215156466 0.02173847731833557 0.08069991180476269 0.024880710386198653 0.02702868416654858 0.16050328098958427 1.1034520054501762e-07 6.957246551692577 3.8184369449652964 EISEGDEVEVYSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EISEGDEVEVYSR 13 0 B4DXZ6;P51114;P51114-2;C9JAJ4 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 0 4956450.0 639550.0 2164800.0 2152100.0 False True 876008.9181888883 2069151.9779637125 1643818.3038907833 1.0 2.362021590192937 1.8764858094016996 19.740586031662108 -10.317912255625526 5.284670920075277 0.9997218242523765 2.119253699797392 0.8763175259264532 0.19821915246731708 0.0006498118785116867 8.387057712354957e-05 0.1919703314106182 0.06397495636706851 4.8093650651183545e-11 10.317912255625526 1.1195318755450154 EISFAYEVLSNPEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 EISFAYEVLSNPEKR 15 1 O60884 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 62138200.0 9645200.0 27376000.0 25117000.0 True False 14632473.558572222 22490538.91033573 20152613.94082783 1.0 1.5370291851414264 1.377252715349806 23.802670335878013 -9.992156676299462 4.516107607263488 0.9999876137993099 1.457140950200862 0.9160703369857781 0.06522847083731821 9698125.131104937 7152560.259257195 1081.6329933696572 0.022329438939996938 1.0182239867798051e-10 9.992156676299462 0.4571533364015522 EISFAYEVLSNPEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EISFAYEVLSNPEKR 15 1 O60884 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 48545200.0 9645200.0 18390000.0 20510000.0 True False 12485901.535316039 17366580.333890796 16777390.450371522 1.0 1.3908951856435747 1.34370677222763 23.573796657970462 -10.095970295665166 4.478863201911985 0.9999675869713771 1.3673009789543094 0.987772301309637 0.019264589169555344 13404468.579413764 0.1670031671887751 4535.5504409308305 0.0065947812714126286 8.01732897443858e-11 10.095970295665166 0.36733339198293224 EISHVLNFLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EISHVLNFLIR 11 0 Q8TED0;H0Y8P4;Q8TED0-3;Q8TED0-2 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 0 17386180.0 4128980.0 10438600.0 2818600.0 False True 5413132.765099198 8881201.56934412 2526958.3099203524 1.0 1.6406768418105424 0.46681993950208334 22.368032342043513 -6.758518052435659 1.6182231267770624 1.3728284649288531 0.46286738666438687 0.6848257867382024 0.2694145407045851 0.2854115372154391 1.4727241105236208 0.1313866538601734 0.3161846232647542 1.7437408734129956e-07 6.758518052435659 -0.9099610782644663 EISHVLNFLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EISHVLNFLIR 11 0 Q8TED0;H0Y8P4;Q8TED0-3;Q8TED0-2 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 0 28899400.0 11630500.0 8833900.0 8435000.0 False True 11261296.14371383 12361322.338179916 6225620.455424126 1.0 1.0976820234924851 0.5528333840060969 23.424869551353627 -6.860526533119596 1.1829540241954173 1.0530800718055573 0.5261677895382544 0.9542849523287349 0.05071517646529988 0.14626671207464217 0.3886188552546151 0.033428648600212864 0.07808542196011503 1.3787117183264034e-07 6.860526533119596 -0.5269122822673029 EISHVLNFLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EISHVLNFLIR 11 0 Q8TED0;H0Y8P4;Q8TED0-3;Q8TED0-2 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 0 19161500.0 3499100.0 7331000.0 8331400.0 False True 5308390.518475521 6022725.772635564 6684695.138217665 1.0 1.1345672010515888 1.2592696628011828 22.339843077625332 -6.972039659633075 0.20366232271389498 0.9291928692092372 1.468100784634636 0.9999942220277398 0.0002544232368089033 0.07564621047838252 0.006605890573470394 0.003929244886601721 0.013118571025960164 1.0664987244610604e-07 6.972039659633075 0.5389079154253987 EISHVLNFLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EISHVLNFLIR 11 0 Q8TED0;H0Y8P4;Q8TED0-3;Q8TED0-2 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 0 52486980.0 4128980.0 19141800.0 29216200.0 False True 5655575.487488946 18296051.98253224 22315935.28652663 1.0 3.235046906014443 3.9458292681077487 22.431242403566404 -9.53442117873146 0.33550379914883205 1.0309731000677171e-19 4.143861765693057 0.9985322610258834 0.04808605642312084 0.8959642729186186 0.13702741559874815 1.2340615212820236 0.21856332190478753 2.9213179099071656e-10 9.53442117873146 4.143861765693057 EISHVLNFLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EISHVLNFLIR 11 0 Q8TED0;H0Y8P4;Q8TED0-3;Q8TED0-2 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 0 20666850.0 11630500.0 4027350.0 5009000.0 False True 9671276.06851143 4005653.8661836158 6056358.741000744 1.0 0.4141804905379102 0.6262212657458467 23.205274826787903 -10.12229668834241 5.213113155636901 1.0000127494886906 0.5202008781413997 0.8722342957122355 0.08656528398896364 1.2827654803686262e-05 2.1596978356325326e-06 0.08381870197647862 0.027938825270504144 7.54576562451885e-11 10.12229668834241 -0.47981187134729086 EISHVLNFLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EISHVLNFLIR 11 0 Q8TED0;H0Y8P4;Q8TED0-3;Q8TED0-2 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 0 17256600.0 3499100.0 7537400.0 6220100.0 False True 4529653.927572718 7117937.064092905 5088105.6236155955 1.0 1.5714085839460934 1.1232879387635983 22.11096939971778 -10.20286522783576 4.672940397546714 0.9999345670741749 1.3473482613569396 0.4447793977944864 0.18294448732452656 0.000124736753920368 2.1278079059621705e-05 0.17716851796822086 0.05904507938967568 6.268083484040498e-11 10.20286522783576 0.3474136942827647 EISLLK(ub)ELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EISLLKELR 9 1 P06493;A0A024QZP7;P06493-2;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 48066600.0 22673000.0 8476300.0 16917300.0 True False 29724522.56564431 7211669.0803586235 15166860.078200387 1.0 0.24261681796342432 0.5102473906756803 24.82515030184575 -10.336639689348312 5.751844961114887 1.0000953538180513 0.3764321043227365 0.8786152928992415 0.10925972378565231 0.00013362035483668473 1.5410335998170896e-05 0.1058062797316309 0.0352634242194198 4.60638582020843e-11 10.336639689348312 -0.6236632494953147 EISLLK(ub)ELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EISLLKELR 9 1 P06493;A0A024QZP7;P06493-2;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 79250000.0 17545000.0 12823000.0 48882000.0 True False 16988043.57864745 17943290.771061603 36078337.771433525 1.0 1.0562305593337904 2.123748835727086 24.01801637889352 -6.917804343721645 0.8408567507258926 0.9745309423520321 2.2874889795595497 0.9935488539046048 0.0415246568407055 0.0994808107267545 0.11243770694039765 0.03536788346692858 0.10381757274467776 1.208358096224124e-07 6.917804343721645 1.3129580372075176 up EISLLK(ub)ELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EISLLKELR 9 1 P06493;A0A024QZP7;P06493-2;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 484545000.0 25226000.0 42467000.0 416852000.0 True False 38269686.267629795 34888432.05381455 334461019.4872782 1.0 0.9116466701563932 8.739580908719919 25.189698738147396 -6.904347055217754 0.9333661478069631 0.7122109402205385 9.63785301682799 0.9886079557553579 0.39165606715410206 0.1082761852920523 0.1599190598194758 0.3119491205098182 0.8308641701630831 1.2463870981095296e-07 6.904347055217754 8.925642076607451 up EISLLK(ub)ELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EISLLKELR 9 1 P06493;A0A024QZP7;P06493-2;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 47289800.0 22673000.0 7206800.0 17410000.0 True False 31055820.81478641 6888379.746299362 13298116.570205158 1.0 0.22180639782090839 0.42820045393466494 24.88836036336864 -10.277175871195146 6.009201269384629 1.0000305989057734 0.3250034258825227 0.9344731448507467 0.08426002057034944 3.4543413814805255e-05 4.155151436713906e-06 0.08158809749896986 0.02719480470167063 5.282312967600032e-11 10.277175871195146 -0.6750271730232507 EISLLK(ub)ELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EISLLKELR 9 1 P06493;A0A024QZP7;P06493-2;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 68049000.0 17545000.0 15388000.0 35116000.0 True False 14589444.875287654 15305101.789721148 42458593.24196088 1.0 1.049053059972536 2.9102267841512885 23.798421654327797 -6.91255310755031 0.8781528713405145 0.9469224119583962 3.1643783444604616 0.9918502287410407 0.0802692654421051 0.1027542482528578 0.129783010294034 0.06655856326010649 0.18715413887989737 1.2230575487362763e-07 6.91255310755031 2.2174559325020655 up EISLLK(ub)ELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EISLLKELR 9 1 P06493;A0A024QZP7;P06493-2;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 560010000.0 25226000.0 37524000.0 497260000.0 True False 32655554.27880007 35435756.41375298 406763782.3184669 1.0 1.0851371901764906 12.45618980604893 24.960825060239845 -6.908541529853868 0.9056127617166425 0.6314857111132772 13.880754632180722 0.9903593861272448 0.5282975592806941 0.10539024228352194 0.14405839588800387 0.42942935744412947 1.1737710902264684 1.2344072680694877e-07 6.908541529853868 13.249268921067443 up EISLWFKPEELVDYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EISLWFKPEELVDYK 15 1 Q32Q12;P22392-2;P22392 Q32Q12 NME1-NME2;NME2 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B 0 25624900.0 12163800.0 10719400.0 2741700.0 False True 15946859.594406746 9120107.303893935 2458015.1842434616 1.0 0.5719061643392628 0.1541378833676816 23.926769007094762 -7.74979675297168 0.397125631610686 1.0491755127144904 1.5701541725737081e-16 0.9981927062221811 0.01468077824035661 0.11660224522918258 0.06715879419877963 0.03125533897352954 0.07753758741195144 1.779111828149982e-08 7.74979675297168 -1.0491755127144902 down EISLWFKPEELVDYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EISLWFKPEELVDYK 15 1 Q32Q12;P22392-2;P22392 Q32Q12 NME1-NME2;NME2 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B 0 142963800.0 77131000.0 31737800.0 34095000.0 False True 74682518.62437476 44410869.050440565 25164496.671924815 1.0 0.5946621762157043 0.33695297287030257 26.154267246644746 -8.501564740284731 0.1861167891648807 1.3422355758699414 1.191114727012043e-20 0.9997769422589178 0.00407601590353376 0.1567861440602406 0.046883543388790645 0.15559871854958204 0.1313669598645458 3.1509046397928073e-09 8.501564740284731 -1.3422355758699414 down EISLWFKPEELVDYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EISLWFKPEELVDYK 15 1 Q32Q12;P22392-2;P22392 Q32Q12 NME1-NME2;NME2 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B 0 415502000.0 103942000.0 199530000.0 112030000.0 False True 157687613.17806932 163922312.56499454 89887221.3955067 1.0 1.039538295122044 0.570033495871367 27.232494095774946 -6.886440187511112 1.043188814840905 1.0274215523535084 0.5323562622881677 0.9785211241111216 0.03116103934417543 0.12207991592400215 0.23908877227554307 0.022859330992972986 0.05630632142955154 1.298852433813816e-07 6.886440187511112 -0.4950652900653407 EISLWFKPEELVDYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EISLWFKPEELVDYK 15 1 Q32Q12;P22392-2;P22392 Q32Q12 NME1-NME2;NME2 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B 0 31309500.0 12163800.0 8851700.0 10294000.0 False True 16661085.574335061 8460602.625342464 7862769.211584841 1.0 0.50780620431932 0.47192418384170276 23.989979068617654 -13.999999999999998 0.37163567121835817 7.9267713897757925 0.4682992940566769 0.9997936874174679 0.0034605506461539504 23.011724736102163 0.1980183493762378 127.0759636635752 0.00997712094274952 1.0000000000000041e-14 13.999999999999998 -7.458472095719116 EISLWFKPEELVDYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EISLWFKPEELVDYK 15 1 Q32Q12;P22392-2;P22392 Q32Q12 NME1-NME2;NME2 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B 0 145391300.0 77131000.0 29892800.0 38367500.0 False True 64137843.98266236 29731761.553143784 46389966.85872353 1.0 0.46356035231213616 0.7232854112037753 25.934672522079023 -10.440783947103466 6.147543417137902 1.0001483672231852 0.593422881757959 0.7656630413943231 0.10603231128313802 0.00021569297363081523 1.962083183239708e-05 0.102702350963926 0.0342217813132895 3.6242325196090635e-11 10.440783947103466 -0.40672548546522624 EISLWFKPEELVDYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EISLWFKPEELVDYK 15 1 Q32Q12;P22392-2;P22392 Q32Q12 NME1-NME2;NME2 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B 0 281399000.0 103942000.0 92818000.0 84639000.0 False True 134554968.00313318 87652596.70642054 69235570.46947806 1.0 0.6514259414366589 0.514552316402512 27.003620417867396 -13.999999999999998 0.12918431846304332 2.656371397286683 0.32086966707647385 0.9996493241968696 0.003827066383367423 11.938060323500958 0.11169044371899578 5.024628965459549 0.17219748780220076 1.0000000000000041e-14 13.999999999999998 -2.3355017302102095 EISSSQWEK(ub)LQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EISSSQWEKLQK 12 1 O43913;O43913-2 O43913 ORC5 Origin recognition complex subunit 5 1 13816700.0 4344900.0 5856300.0 3615500.0 True False 3612976.8617063193 5824750.949515468 4371484.333816775 1.0 1.6121749937708107 1.209939753600368 21.784756584789676 -10.075004877135232 4.697402908170224 0.9999814293473066 1.4110573736943526 0.5820205497518469 0.16421184919394544 3.1938194908261146e-05 6.28909928667857e-06 0.15900461651569778 0.05299914642725317 8.41385692814923e-11 10.075004877135232 0.411075944347046 EISYAIK(ub)NIHGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EISYAIKNIHGVR 13 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3;K7EMQ3 P50570 DNM2 Dynamin-2 1 9387300.0 2592000.0 3560900.0 3234400.0 True False 2509718.3787890696 4982785.9398481855 2387213.6100798803 1.0 1.985396442071067 0.9511878425306438 21.259094054488617 -6.657146641898182 1.9830373900639426 1.6357887662069877 0.9555296461111837 0.22344926015805933 0.4198511219168809 0.49130931359852537 3.711002157983864 0.17123409057378045 0.46528463054331015 2.2021827584949992e-07 6.657146641898182 -0.6802591200958039 EISYAIK(ub)NIHGVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EISYAIKNIHGVR 13 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3;K7EMQ3 P50570 DNM2 Dynamin-2 1 6374100.0 1625700.0 2590500.0 2157900.0 True False 2226765.22289059 2476043.1443620618 1648248.4633455337 1.0 1.1119462073993958 0.7401985833090761 21.086518026135675 -6.825957411348115 1.3458982299046813 1.0600028658502716 0.7309976598292603 0.8975431505866386 0.04984269511264222 0.18585100461457152 0.6598233722016591 0.02908849388492062 0.06696224732655169 1.4929408061404522e-07 6.825957411348115 -0.32900520602101124 EISYAIK(ub)NIHGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EISYAIKNIHGVR 13 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3;K7EMQ3 P50570 DNM2 Dynamin-2 1 8110300.0 2592000.0 3709800.0 1808500.0 True False 2155362.8450695714 3689814.571062354 2186648.9884407767 1.0 1.7119226952913598 1.0145154879340956 21.039499329922894 -10.330186328339812 5.002314302166375 0.9998379868901933 1.3632190916128222 0.2656035065199501 0.28471530016110724 0.0005146665963261161 6.891417381504559e-05 0.27579639163878894 0.09189146799448773 4.675345087144285e-11 10.330186328339812 0.36338110472262886 EITALAPSTMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 EITALAPSTMK 11 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 0 531439000.0 2145000.0 280224000.0 249070000.0 False True 2812115.7722095493 238415671.5045968 223298625.64814517 1.0 84.78159891591791 79.40591488262017 21.423224559379868 -10.080331338589378 8.760063268554353 0.999999460576413 82.09375689926904 0.9967150790802375 2.1946138166676907 3.0557133733172376e-05 3.2386545428194862e-06 2.124925690383307 0.7083085636092212 8.311294311741641e-11 10.080331338589378 81.09375743869262 EITALAPSTMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 EITALAPSTMK 11 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 0 397962300.0 145888000.0 43576300.0 208498000.0 False True 141256865.29505375 60976543.83740245 153886118.99407473 1.0 0.43167136485746155 1.0894063001655978 27.073745745468756 -6.678192609171021 1.9088329860509718 0.6398144242073094 1.0868355802074767 0.31561951168225777 0.24096960685149504 0.442563664070607 3.1162540230819196 0.10136648122920545 0.26791654667348513 2.0980092122627177e-07 6.678192609171021 0.44702115600016734 EITALAPSTMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EITALAPSTMK 11 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 0 541862000.0 2145000.0 306923000.0 232794000.0 False True 2938064.4664454167 293362127.0013652 177812851.7429259 1.0 99.84877130905366 60.52040510807809 21.48643462090276 -9.82196257930551 7.478270799130041 1.0000004328958114 80.18458820856608 0.8438757832596813 16.055738268285815 3.169840420390315e-05 3.9650182134407714e-06 15.54590844887568 5.181967243677892 1.5067368875730566e-10 9.82196257930551 79.18458777567027 EITALAPSTMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EITALAPSTMK 11 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 0 13240700.0 4654100.0 4973000.0 3613600.0 False True 6024824.196026466 4696248.17838167 2955961.878667117 1.0 0.7794830231692026 0.4906303955917342 22.52248771353462 -6.967411342617433 0.3139233752154705 1.0424878868118905 0.21839127455418178 0.9999545724157415 0.0014057640046912902 0.07715194249489218 0.012022411125007215 0.004491502242110192 0.02554899269472257 1.0779252801604782e-07 6.967411342617433 -0.8240966122577087 down EITALAPSTMK(ub)IK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EITALAPSTMKIK 13 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 45838400.0 18342900.0 22046400.0 5449100.0 True False 24047719.532896265 18757163.05619413 4885279.403458091 1.0 0.7799975806660221 0.2031493837399108 24.51939675261125 -7.0437389472352105 0.5412633241565208 1.0072514467034972 3.5604029808314256e-13 0.9993832977690719 0.008344304478079715 0.07428553067224951 0.03242736739724135 0.009333631508138573 0.04266260405046577 9.041928172758392e-08 7.0437389472352105 -1.0072514467031413 down EITALAPSTMK(ub)IK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EITALAPSTMKIK 13 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 49016100.0 19107100.0 4371200.0 25537800.0 True False 18500555.569197763 6116642.955506855 18848684.062422097 1.0 0.33061942019139534 1.0188171912958088 24.14106525954186 -10.942858051401716 12.639234220003393 1.0616636391048007 0.674718305743603 0.22950871870511869 0.2809555635544177 0.13778871815814456 0.0006229415055646566 0.0767798672400996 0.09067801822254826 1.1406225376651182e-11 10.942858051401716 -0.38694533336119763 EITALAPSTMK(ub)IK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EITALAPSTMKIK 13 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 147158200.0 32736100.0 15920100.0 98502000.0 True False 49663057.02948369 13079033.770690972 79033036.5250397 1.0 0.26335539036443695 1.5913848492677325 25.56566973413411 -6.756137863457494 1.6269907184406163 0.5700703790986895 1.595335910104505 0.6750233570058286 0.3096866016288118 0.2894483978797786 1.5091621236404793 0.1502488027214257 0.3624644243088903 1.7533238342671078e-07 6.756137863457494 1.0252655310058154 EITALAPSTMK(ub)IK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EITALAPSTMKIK 13 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 51328300.0 18342900.0 19774100.0 13211300.0 True False 25124765.828233834 18900414.877795745 10091063.035264293 1.0 0.7522623298067318 0.4016380930374487 24.58260681413414 -6.966205068691 0.336729228805047 1.0395003905058253 0.10280529622267197 0.9999358742021643 0.001965768614202624 0.07755438012345153 0.0134309445081578 0.005000647493440245 0.03042197772325548 1.0809234315835276e-07 6.966205068691 -0.9366950942831533 down EITALAPSTMK(ub)IK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EITALAPSTMKIK 13 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 57658900.0 19107100.0 24141400.0 14410400.0 True False 15888400.238051226 24011345.48650727 17423548.013838537 1.0 1.5112500394471655 1.0966206636783216 23.921470534976137 -9.987246400739448 5.398994828424541 0.9999989650276885 1.3039353515634031 0.417399479231811 0.1692717338360443 2.1089006852990696e-06 3.953590347082661e-07 0.16389720833866334 0.05463221717721957 1.0298016877503487e-10 9.987246400739448 0.30393638653571464 EITALAPSTMK(ub)IK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EITALAPSTMKIK 13 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 92292400.0 32736100.0 9721200.0 49835100.0 True False 42377526.775003046 9180206.674378414 40765623.151307166 1.0 0.21662912805457732 0.9619632445221724 25.33679605622656 -10.786603579256084 10.860739978209924 1.0019764493867815 0.5892961868545499 0.28818026228315385 0.30428137887228945 0.014596479067226912 0.00028679717877725893 0.2953156322440959 0.09820639274445048 1.6345432659855588e-11 10.786603579256084 -0.41268026253223167 EITEACVGSCEAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EITEACVGSCEAKR 14 1 J3KR72;P49848-4;P49848-2;P49848;P49848-3;C9JFL8;C9JTY6 J3KR72 TAF6 Transcription initiation factor TFIID subunit 6 1 23143700.0 1034900.0 1682800.0 20426000.0 True False 1339698.4509288117 1589150.7006999126 16708677.588458743 1.0 1.186200297237155 12.471969029205514 20.353476874255524 -6.910483795201124 0.8924372916931457 0.6558945084371142 13.945641725304437 0.9911027810184221 0.5060152211690372 0.10409887127862638 0.1370396686772736 0.415274998083097 1.1502206737592717 1.2288990395448305e-07 6.910483795201124 13.289747216867323 up EITENLMATGDLDQDGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EITENLMATGDLDQDGR 17 0 P13796;Q5TBN3 P13796 LCP1 Plastin-2 0 12115400.0 2675500.0 5767000.0 3672900.0 False True 3507606.4095788533 4906586.079589938 3292863.540944605 1.0 1.398841690501716 0.9387779461094007 21.74205544059432 -6.6774175485971705 1.9107615543853338 1.2529272179951796 0.9405490297856625 0.3125014659859515 0.1691335666777335 0.4442712021030397 3.1336816789903006 0.07108034634602899 0.18811289782867816 2.1017567525728576e-07 6.6774175485971705 -0.3123781882095171 EITENLMATGDLDQDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EITENLMATGDLDQDGR 17 0 P13796;Q5TBN3 P13796 LCP1 Plastin-2 0 13456800.0 2675500.0 3670300.0 7111000.0 False True 3664704.652668859 3508134.0099409665 5431528.255642104 1.0 0.9572760542615983 1.4821189619432327 21.805265502117212 -6.887174757550219 1.0389835752502348 0.9698599483950385 1.5248333184296046 0.9790262615950979 0.03446547351239961 0.12146401731457268 0.23549431395651851 0.025365182269544467 0.06262377588936224 1.2966573986659461e-07 6.887174757550219 0.554973370034566 EIVETFANK(ub)SGQSALYDALFSSQSPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIVETFANKSGQSALYDALFSSQSPK 26 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 57893000.0 30915000.0 15740000.0 11238000.0 True False 29933620.24701545 22025064.083015673 8294430.667226588 1.0 0.7357968699162506 0.27709413691962603 24.835263436751767 -7.024071226253804 0.4095094423371971 1.023598026201999 8.0614831401373e-17 0.9998453713274127 0.003713881996812785 0.07339186871682156 0.0184638465012271 0.005925447356852436 0.03575780431446107 9.460819869285743e-08 7.024071226253804 -1.023598026201999 down EIVETFANK(ub)SGQSALYDALFSSQSPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIVETFANKSGQSALYDALFSSQSPK 26 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 124021000.0 51616000.0 37933000.0 34472000.0 True False 78305245.63505839 31163559.778118256 27658594.090385675 1.0 0.39797537860178656 0.3532150862445226 26.222605620491528 -13.999999999999998 0.3687490559071856 9.320085101671799 0.348483396224045 0.9997887521196903 0.004286383477259768 22.674140980692403 0.19699069138162512 149.04279249155894 0.012558667698476291 1.0000000000000041e-14 13.999999999999998 -8.971601705447753 EIVETFANK(ub)SGQSALYDALFSSQSPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIVETFANKSGQSALYDALFSSQSPK 26 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 55655300.0 30915000.0 19509000.0 5231300.0 True False 25707192.266715188 19403901.144766714 6325140.643201681 1.0 0.7548043731672026 0.24604556489785395 24.615668712186043 -7.027650689537279 0.464417527297807 1.0144034699006912 5.197554150061404e-11 0.9997131816983009 0.005317929058983798 0.07376336964100008 0.023411121615827788 0.00692449929469392 0.03859582314518992 9.383164073947937e-08 7.027650689537279 -1.0144034698487157 down EIVETFANK(ub)SGQSALYDALFSSQSPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIVETFANKSGQSALYDALFSSQSPK 26 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 117553000.0 51616000.0 41382000.0 24555000.0 True False 66817929.50347052 39079055.32229844 20086241.955576424 1.0 0.5848588187736149 0.3006115589758456 25.993731942583977 -8.189457557790998 0.22015482832656172 1.2399395676809015 8.119172979469434e-23 0.9996981127322498 0.004989828048805599 0.08715712044140762 0.04588079068567001 0.0968456608615762 0.1088769891155278 6.464611674923882e-09 8.189457557790998 -1.2399395676809015 down EIVEWK(ub)IPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIVEWKIPK 9 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 27935600.0 1230600.0 3695000.0 23010000.0 True False 1593035.9587525313 3489370.001833954 18822416.10253772 1.0 2.190389980001705 11.815437058481159 20.603347401741978 -6.929898423702982 0.7476284563689548 0.8530795606772177 13.786288385921496 0.9965181953622934 0.2857296752441031 0.09269062179457611 0.0779396103176592 0.2601562033936833 0.8713878713311792 1.1751723815960334e-07 6.929898423702982 12.933208825244279 EIVHIQAGQCGNQIGAK(ub)FWEVISDEHGIDPTGTYHGDSDLQLDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLDR 44 1 P07437 P07437 TUBB Tubulin beta chain 1 350644000.0 143241000.0 28788000.0 178615000.0 True False 217307069.31981152 23650556.478329375 143311666.96026435 1.0 0.1088347312048223 0.659489207639868 27.69515986738128 -10.017361752031414 6.282580216605241 1.000000413012206 0.38416196977648637 0.6251428114556052 0.22480374864093416 1.3006437432454338e-06 2.0340801563905048e-07 0.2176654396108443 0.0725550978876035 9.608116226762859e-11 10.017361752031414 -0.6158384432357196 EIVHK(ub)PGPITLTVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIVHKPGPITLTVAK 15 1 Q92997-2;Q92997 Q92997-2 DVL3 Segment polarity protein dishevelled homolog DVL-3 1 10295600.0 2119000.0 3989000.0 4187600.0 True False 2051733.504881955 5581828.502360191 3090741.934692833 1.0 2.7205426479991797 1.5064051580473932 20.96841192397616 -10.494929778422193 5.37890278907279 0.9978623111624694 2.1134739030222183 0.5286146324347906 0.49566955466092105 0.012722432152932825 0.0011946147565319127 0.48051167546490026 0.1599766608686468 3.1994123845651096e-11 10.494929778422193 1.115611591859749 EIVHK(ub)PGPITLTVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIVHKPGPITLTVAK 15 1 Q92997-2;Q92997 Q92997-2 DVL3 Segment polarity protein dishevelled homolog DVL-3 1 7297900.0 2119000.0 3186500.0 1992400.0 True False 1762042.3876166714 3169333.6920292736 2409001.628183246 1.0 1.7986705168404584 1.367164402578106 20.748817199410436 -10.18938644320737 4.51088840258116 0.9998718308402719 1.5829174596942446 0.7087270979983991 0.17616163350409875 20272263.137617383 45791902.17860291 16078.518010190895 0.060304810568517594 6.465670324822588e-11 10.18938644320737 0.5830456288539727 EIVHLQAGQCGNQIGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIVHLQAGQCGNQIGAK 17 0 P04350;M0R2D3;M0QZL7;M0R278;M0R0X0;M0QY37;M0QX14;M0R2T4;P68371;M0QY85;M0QYM7;M0R042 P04350;P68371;M0QY85;M0QYM7 TUBB4A;TUBB4B Tubulin beta-4A chain;Tubulin beta-4B chain 0 1037568100.0 338136000.0 391912200.0 307519900.0 False True 443299570.51368237 333440427.4217901 275700690.68717635 1.0 0.7521785483243516 0.6219286212429725 28.723706723862215 -13.999999998143224 0.08084724259700118 2.3295585584556995 0.2389977826115151 0.9998831554161464 0.001695076729264222 12.250100953558473 0.08024795820388216 2.901623439408492 0.3474015072012584 1.0000000042753849e-14 13.999999998143224 -2.0905607758441844 EIVHLQAGQCGNQIGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIVHLQAGQCGNQIGAK 17 0 P04350;M0R2D3;M0QZL7;M0R278;M0R0X0;M0QY37;M0QX14;M0R2T4;P68371;M0QY85;M0QYM7;M0R042 P04350;P68371;M0QY85;M0QYM7 TUBB4A;TUBB4B Tubulin beta-4A chain;Tubulin beta-4B chain 0 408045000.0 114487000.0 59087000.0 234471000.0 False True 110852672.85201533 82680747.23463438 173056011.1207766 1.0 0.7458615575739023 1.5611352136885384 26.724068315626702 -6.822957240403984 1.3590811542089714 0.8634170185137434 1.5800807006260498 0.8910414812437318 0.11243115465684071 0.18966527588919435 0.687567182004671 0.06499518226779218 0.1496946602125523 1.5032899691389345e-07 6.822957240403984 0.7166636821123064 EIVHLQAGQCGNQIGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIVHLQAGQCGNQIGAK 17 0 P04350;M0R2D3;M0QZL7;M0R278;M0R0X0;M0QY37;M0QX14;M0R2T4;P68371;M0QY85;M0QYM7;M0R042 P04350;P68371;M0QY85;M0QYM7 TUBB4A;TUBB4B Tubulin beta-4A chain;Tubulin beta-4B chain 0 1933916800.0 235515800.0 1403557000.0 294844000.0 False True 357294687.11130804 1153081287.3091063 236567954.16528416 1.0 3.2272556209319925 0.6621087933826066 28.412539220642692 -6.6771130527573135 1.9119847922268418 2.4128293967193684 0.672041734870089 0.3110328498836986 0.9445625431816205 0.44496796359606994 3.1423852842135633 0.3967612325107829 1.0503787959006874 2.1032308689136066e-07 6.6771130527573135 -1.7407876618492795 EIVHLQAGQCGNQIGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIVHLQAGQCGNQIGAK 17 0 P04350;M0R2D3;M0QZL7;M0R278;M0R0X0;M0QY37;M0QX14;M0R2T4;P68371;M0QY85;M0QYM7;M0R042 P04350;P68371;M0QY85;M0QYM7 TUBB4A;TUBB4B Tubulin beta-4A chain;Tubulin beta-4B chain 0 885266500.0 338136000.0 232249500.0 314881000.0 False True 463154016.98181254 221987949.14360788 240512592.9777583 1.0 0.4792961757952864 0.5192929007613528 28.786916785385106 -10.1714624309144 5.901530917871148 1.0000064556794224 0.49929453965538945 0.995237093262705 0.01632859459158127 1.3869606592602614e-06 1.9469456058269186e-07 0.01581029739169011 0.0052700312433426695 6.738101815841568e-11 10.1714624309144 -0.500711916024033 EIVHLQAGQCGNQIGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIVHLQAGQCGNQIGAK 17 0 P04350;M0R2D3;M0QZL7;M0R278;M0R0X0;M0QY37;M0QX14;M0R2T4;P68371;M0QY85;M0QYM7;M0R042 P04350;P68371;M0QY85;M0QYM7 TUBB4A;TUBB4B Tubulin beta-4A chain;Tubulin beta-4B chain 0 278606000.0 114487000.0 80818000.0 83301000.0 False True 95201013.13405849 80382617.39288291 100718853.95969327 1.0 0.8443462390436027 1.0579598960555678 26.50447359106098 -6.711331837384105 1.7905430463758911 0.9044373013360603 1.0574760428708905 0.47138195752870826 0.06557818161892887 0.3724073715720522 2.3282441794008255 0.029137218223947926 0.07390054406974517 1.9438742312014326e-07 6.711331837384105 0.1530387415348302 EIVHLQAGQCGNQIGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIVHLQAGQCGNQIGAK 17 0 P04350;M0R2D3;M0QZL7;M0R278;M0R0X0;M0QY37;M0QX14;M0R2T4;P68371;M0QY85;M0QYM7;M0R042 P04350;P68371;M0QY85;M0QYM7 TUBB4A;TUBB4B Tubulin beta-4A chain;Tubulin beta-4B chain 0 766652300.0 235515800.0 336784500.0 194352000.0 False True 304879845.8104746 318042146.5176311 158981930.21992227 1.0 1.0431720918520102 0.5214576575151897 28.18366554273514 -6.886825592593357 1.0410195167133265 1.0302027348514222 0.47928642187651294 0.9787859135373195 0.03443480165228363 0.12175481963925405 0.23721654078161375 0.02530355110334189 0.06240032451988826 1.2977003070902614e-07 6.886825592593357 -0.5509163129749093 EIVK(ub)NSSNDETIAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIVKNSSNDETIAAK 15 1 Q96HU1;Q96HU1-2;B0QY80 Q96HU1 SGSM3 Small G protein signaling modulator 3 1 4653710.0 918910.0 1224800.0 2510000.0 True False 889739.7050359031 1713869.027247623 1852555.7016140542 1.0 1.9262589019543241 2.082132213644775 19.763023809191175 -10.86612164751119 0.34038181697803255 1.7566113680795955e-14 2.112443140886722 0.9992878576483254 0.01274630513328348 2.598927953601921 0.16874611657809677 2.1324425009033234 0.04791475769594803 1.3610633901138055e-11 10.86612164751119 2.1124431408867044 EIVK(ub)NSSNDETIAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIVKNSSNDETIAAK 15 1 Q96HU1;Q96HU1-2;B0QY80 Q96HU1 SGSM3 Small G protein signaling modulator 3 1 13636900.0 1371800.0 2945200.0 9319900.0 True False 2081120.8920135826 2419606.049047368 7477817.679942708 1.0 1.1626456004227055 3.5931683299318413 20.98892934277928 -6.920472487744243 0.8212297927366815 0.9472797449509769 3.9893839643077236 0.9943108507331812 0.08945242038380966 0.0978944949917292 0.10418439167283404 0.07726575013811 0.23249812273845455 1.2009571504117146e-07 6.920472487744243 3.0421042193567467 up EIVK(ub)NSSNDETIAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIVKNSSNDETIAAK 15 1 Q96HU1;Q96HU1-2;B0QY80 Q96HU1 SGSM3 Small G protein signaling modulator 3 1 4879210.0 918910.0 2596000.0 1364300.0 True False 764114.3796153077 2582014.832734342 1649568.8221895238 1.0 3.379094676943855 2.1587982979982616 19.54342908462545 -9.199117312302432 15.491778171132513 0.9999841249328354 2.7689464874710583 0.7369668565340857 0.49818391064809303 0.0 0.0 0.4823644972840407 0.16078816576134686 6.322410463712146e-10 9.199117312302432 1.768962362538223 EIVPVLVSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIVPVLVSTR 10 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 6748550.0 675050.0 2772600.0 3300900.0 False True 884997.087193499 2358938.887510154 2959354.532468637 1.0 2.665476442403688 3.34391443236648 19.755313181272662 -9.433036226064113 0.2717958768824381 2.8689381738857884e-18 3.6933965989026865 0.9989184761687872 0.03238581045555126 0.8292652118429316 0.10697304533606201 1.0085580205771632 0.26694941256239557 3.6894682210570954e-10 9.433036226064113 3.6933965989026865 EIVPVLVSTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIVPVLVSTR 10 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 5673810.0 2586300.0 909910.0 2177600.0 False True 2504199.322169044 1273241.8081179636 1607221.2334003071 1.0 0.5084426774044204 0.6418104258602674 21.255917967721015 -10.373018164530913 8.783623240377507 1.000001321561476 0.5751265516323628 0.9311855044323627 0.05444715531011403 1.4090665847385847e-06 1.0061493741452833e-07 0.0527183948006503 0.017572743813703363 4.23625247392853e-11 10.373018164530913 -0.4248747699291132 EIVPVLVSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIVPVLVSTR 10 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 5948150.0 675050.0 2733300.0 2539800.0 False True 924634.2275403157 2612533.7681856137 1939951.5488229238 1.0 2.8254781083925455 2.098074558610625 19.818523242795553 -10.442312119573081 5.834351066496258 0.9991850442172282 2.4617763335015863 0.8433719941809237 0.29696125567581805 0.0031493273833372837 0.00030103393087414846 0.28765701149742645 0.09584383314177337 3.6115021723385035e-11 10.442312119573081 1.462591289284358 EIVQQVK(ub)QQEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIVQQVKQQEQK 12 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 19977450.0 5685700.0 5600650.0 8691100.0 True False 7360250.731902547 5288968.90413298 7109408.978216667 1.0 0.718585425522024 0.9659194010064599 22.811323482822637 -10.225345721231347 7.181770067725106 1.0000004310958428 0.8422524135401888 0.3516476483506831 0.10097367266515198 6.969870881851393e-07 7.505618943843527e-08 0.0977676062148395 0.032589112719794394 5.951881538439323e-11 10.225345721231347 -0.15774801755565404 EIVSGMK(ub)YIQHTYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIVSGMKYIQHTYR 14 1 P52565;J3KTF8;J3QQX2;J3KRY1;P52565-2 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 1 12492500.0 3509400.0 6297700.0 2685400.0 True False 4600857.385077947 5358107.708242335 2407540.568175728 1.0 1.1645889580538604 0.5232808510831378 22.13347130656741 -6.838604458782637 1.2887743211955551 1.0875833352309534 0.5027531839222343 0.9220371689437845 0.07593428911412277 0.17043922600595676 0.5504926091690345 0.04620980757327176 0.10642704868122084 1.450091948648209e-07 6.838604458782637 -0.5848301513087191 EIVSGMK(ub)YIQHTYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIVSGMKYIQHTYR 14 1 P52565;J3KTF8;J3QQX2;J3KRY1;P52565-2 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 1 13142000.0 3509400.0 3918300.0 5714300.0 True False 4806920.017969021 3745176.549914638 4364700.0297026625 1.0 0.7791218776086519 0.9080034644609708 22.196681368090303 -10.20104410244122 5.02220882293619 1.0000151990542772 0.8435626710849573 0.6626676439621932 0.05261568750529295 8.95512195905066e-06 1.4246225144144687e-06 0.050949868765474034 0.01698164012135704 6.294422599869277e-11 10.20104410244122 -0.15645252796931985 EIVSGMK(ub)YIQHTYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIVSGMKYIQHTYR 14 1 P52565;J3KTF8;J3QQX2;J3KRY1;P52565-2 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 1 12042500.0 3964300.0 5315400.0 2762800.0 True False 3296491.0982674756 5286764.885175711 3340488.706256114 1.0 1.603755243857402 1.0133468001814905 21.652499754884538 -10.247946622705168 4.772013587373395 0.9999204723674195 1.3085510220201328 0.2669460654863427 0.2410332378084821 0.00020399057328718642 3.2148037188503156e-05 0.23343939773648137 0.07779314299255669 5.650064130895507e-11 10.247946622705168 0.3086305496527133 EIYDQFGEEGLK(ub)GGAGGTDGQGGTFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIYDQFGEEGLKGGAGGTDGQGGTFR 26 1 Q9UDY4;C9JUL4 Q9UDY4 DNAJB4 DnaJ homolog subfamily B member 4 1 7477000.0 0.0 1489700.0 5987300.0 True False 0.0 2084544.9786828733 4419046.514850131 0.0 EIYDQFGEEGLK(ub)GGAGGTDGQGGTFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIYDQFGEEGLKGGAGGTDGQGGTFR 26 1 Q9UDY4;C9JUL4 Q9UDY4 DNAJB4 DnaJ homolog subfamily B member 4 1 7255100.0 0.0 3281500.0 3973600.0 True False 0.0 3263821.9081732463 4804461.38814945 0.0 EIYFNSFFK(ub)DR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIYFNSFFKDR 11 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 15953700.0 4508600.0 7536300.0 3908800.0 True False 5910818.261344506 6411913.41626732 3504354.8718571905 1.0 1.0847759367260315 0.5928713617833465 22.494926432361332 -6.862486040451788 1.17319033212524 1.0463313691663993 0.5679038903126247 0.9565867257611897 0.04473705397664932 0.14425815741910925 0.375899250830492 0.0297115833744314 0.0695576863318632 1.3725050767945886e-07 6.862486040451788 -0.4784274788537747 EIYFNSFFK(ub)DR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EIYFNSFFKDR 11 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 45546000.0 13503000.0 14710000.0 17333000.0 True False 13074354.656168504 20583779.71163661 12792967.321145995 1.0 1.5743629611519792 0.9784779178458533 23.6402364017107 -6.654557991600686 1.9925576349747027 1.3713555964840602 0.9809931782671295 0.2126723976603626 0.24487227779580084 0.4974226229326807 3.7905878137875484 0.09949810958107623 0.2712601396856405 2.2153482597898536e-07 6.654557991600686 -0.39036241821693074 EIYFNSFFK(ub)DR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIYFNSFFKDR 11 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 107310800.0 26035800.0 20811000.0 60464000.0 True False 39498212.07193993 17097114.45291486 48513263.89768739 1.0 0.4328579334622815 1.228239491178181 25.23528401387279 -6.715185053104465 1.776201146604399 0.6532179778899876 1.226720953292824 0.49000343140787617 0.23880440726080915 0.36470530877714724 2.245832691065938 0.10685472065805057 0.2698209929259315 1.9267037687810426e-07 6.715185053104465 0.5735029754028365 EIYFNSFFK(ub)DR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIYFNSFFKDR 11 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 17594400.0 4508600.0 7071300.0 6014500.0 True False 6175551.260333705 6758866.584337951 4593998.972515737 1.0 1.094455587754724 0.7439010347179101 22.558136493884223 -6.834964125435847 1.3055427650193665 1.0503240731173924 0.7334713738095494 0.9154546004218032 0.04306198469544627 0.17475929658122152 0.5807637657214745 0.025883100318877722 0.059574123852787486 1.462297961474733e-07 6.834964125435847 -0.316852699307843 EIYFNSFFK(ub)DR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIYFNSFFKDR 11 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 53292600.0 13503000.0 19378900.0 20410700.0 True False 11228342.784326538 19274502.019289535 24678483.001585916 1.0 1.7165936585222976 2.1978740296416857 23.420641677144975 -8.188275629539453 0.13054038668341153 5.531079605955809e-20 3.3309913950492263 0.9999597828066744 0.0031211601893785883 0.08729851811843199 0.02609686896674178 0.2971871397148883 0.31490933948533834 6.482229015199753e-09 8.188275629539453 3.3309913950492263 EIYFNSFFK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIYFNSFFKDR 11 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 86341400.0 26035800.0 29446400.0 30859200.0 True False 33703856.342344545 27807681.954534072 25243142.24213093 1.0 0.8250593543978916 0.7489689602793667 25.00641033596524 -13.999999999972818 0.1133031047420989 1.8397395875980225 0.6157944388699337 0.9997263276369115 0.001738633661504215 11.994223045965274 0.10266743148505382 2.29070485709289 0.11820897841427117 1.0000000000625884e-14 13.999999999972818 -1.2239451487280888 EIYGINFSPNGYHIATGSGDNTCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIYGINFSPNGYHIATGSGDNTCK 24 0 O43172-2;O43172 O43172-2 PRPF4 U4/U6 small nuclear ribonucleoprotein Prp4 0 8580400.0 2752300.0 3292000.0 2536100.0 False True 3608291.9533111122 2800846.432115492 2273688.6999890045 1.0 0.7762250029533568 0.6301288059306225 21.7828846436585 -8.776524032647377 0.07813965847287836 1.6701780606577545 2.3849620397796573e-11 0.9999891247797136 0.0005015733465078728 0.3081590134888377 0.022211346370365613 0.2517126379092693 0.21046209048372072 1.6729230589331937e-09 8.776524032647377 -1.670178060633905 EIYGINFSPNGYHIATGSGDNTCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIYGINFSPNGYHIATGSGDNTCK 24 0 O43172-2;O43172 O43172-2 PRPF4 U4/U6 small nuclear ribonucleoprotein Prp4 0 11845200.0 2752300.0 3794100.0 5298800.0 False True 3769899.688110822 3626464.116589115 4047332.5722115566 1.0 0.9619524169372301 1.073591582549445 21.846094705181393 -6.81474167095684 1.3946103833397572 0.9793779027618345 1.075762025818176 0.871834639744485 0.0165898425682556 0.20039841137464381 0.7672501676972915 0.009351496020073569 0.021588237190743768 1.5319984610904823e-07 6.81474167095684 0.09638412305634148 EIYHFTLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIYHFTLEK 9 0 D6RFN0;Q9BT78;D6RAX7;Q9BT78-2 D6RFN0 COPS4 COP9 signalosome complex subunit 4 0 7041900.0 1900400.0 2381100.0 2760400.0 False True 2491442.8034997773 2025849.1614551048 2474780.287626528 1.0 0.8131228855060834 0.9933121017870276 21.24855002351644 -10.653748514197918 8.095883970781687 1.0001522597144463 0.9032174936514757 0.2778000523811651 0.07356193950671874 0.0002024806862590276 8.659890201803464e-06 0.07133752966950344 0.023742013885353262 2.21948127713817e-11 10.653748514197918 -0.09693476606297058 EIYHFTLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIYHFTLEK 9 0 D6RFN0;Q9BT78;D6RAX7;Q9BT78-2 D6RFN0 COPS4 COP9 signalosome complex subunit 4 0 6517900.0 1900400.0 2277900.0 2339600.0 False True 2603029.2363789575 2177254.8459920264 1787034.6655744973 1.0 0.8364311916145741 0.6865211656479201 21.31176008503933 -6.97216782686026 0.19973220215611134 1.0895389612398032 0.4292755895538717 0.9999947189259926 0.0002941355048806627 0.07560533327023142 0.006446942225058298 0.0048778305182370614 0.015925574434322513 1.0661840301182515e-07 6.97216782686026 -0.6602633716859315 EIYNEK(ub)ELLQGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIYNEKELLQGK 12 1 P60228;H0YBR5;H0YBP5;E5RII3 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 23658500.0 4088000.0 9618100.0 9952400.0 True False 5359407.58824832 8183116.971060159 8922621.118161974 1.0 1.5268696840679636 1.6648521261429685 22.353642107930582 -11.56469095683312 0.2348067787738109 5.722529556147106e-10 1.7380429733926281 0.9993225576064363 0.007456531327676031 4.1368716446528735 0.13456027134375603 2.155973970523648 0.06915960058943994 2.724639466911708e-12 11.56469095683312 1.7380429728203752 EIYNEK(ub)ELLQGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EIYNEKELLQGK 12 1 P60228;H0YBR5;H0YBP5;E5RII3 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 106461000.0 13966000.0 43193000.0 49302000.0 True False 21187443.051364366 35484871.68155065 39557438.09016579 1.0 1.6748067048735078 1.867022745230151 24.336706154720122 -11.059617482459968 0.23919631671539485 4.651041598348835e-11 1.9697886807532405 0.9992588040853718 0.010121905408222772 3.098901610716313 0.12919481188996268 1.7861080679246746 0.09345373400296456 8.717310544912093e-12 11.059617482459968 1.9697886807067302 EIYNEK(ub)ELLQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIYNEKELLQGK 12 1 P60228;H0YBR5;H0YBP5;E5RII3 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 25531500.0 4088000.0 5041500.0 16402000.0 True False 5599444.074046094 4818749.859988935 12528185.409793522 1.0 0.8605764779979241 2.2373980781168514 22.416852169453474 -6.881957977507668 1.0688613289862527 0.911141195223661 2.3386947543597123 0.9752290172796245 0.09739183137109575 0.12590792264351594 0.2619482085634938 0.07006371464066409 0.17030094855662445 1.3123268741025964e-07 6.881957977507668 1.4275535591360513 up EIYNEK(ub)ELLQGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EIYNEKELLQGK 12 1 P60228;H0YBR5;H0YBP5;E5RII3 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 25909200.0 5811800.0 9063400.0 11034000.0 True False 4832769.206394803 9014573.665255949 13341158.384548258 1.0 1.8653019170308631 2.7605618672820147 22.204418668426644 -6.9706980631616595 0.2409298043053481 0.6822214382401531 3.9695662581993587 0.99998732707462 0.002558785945067621 0.07607684020240169 0.008215398012037647 0.021259979207988892 0.08713487162659188 1.0697983822975936e-07 6.9706980631616595 3.2873448199592055 EIYNEK(ub)ELLQGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EIYNEKELLQGK 12 1 P60228;H0YBR5;H0YBP5;E5RII3 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 100432000.0 13966000.0 39488000.0 46978000.0 True False 18079262.311017267 37290458.08725824 38428486.03498552 1.0 2.062609494002082 2.1255560859674953 24.107832476812572 -10.901603976699741 0.508241751239417 1.301926955459315e-14 2.1224109644312943 0.9997737012088572 0.007768252736859966 2.6143362977928946 0.24637573098552973 3.1260049243724137 0.012601445314958848 1.2542844071568195e-11 10.901603976699741 2.1224109644312814 EIYTHFTCATDTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EIYTHFTCATDTK 13 0 P04899-4;P04899;P04899-6;P04899-3;P04899-5;P04899-2;P63096;P63096-2;P08754 P04899-4;P08754 GNAI2;GNAI1;GNAI3 Guanine nucleotide-binding protein G(i) subunit alpha-2;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(k) subunit alpha 0 8820000.0 2370600.0 3315200.0 3134200.0 False True 3107879.5569230565 2820585.082548386 2809903.049369318 1.0 0.9075593281165937 0.9041222473084675 21.567499163804424 EIYTHFTCATDTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EIYTHFTCATDTK 13 0 P04899-4;P04899;P04899-6;P04899-3;P04899-5;P04899-2;P63096;P63096-2;P08754 P04899-4;P08754 GNAI2;GNAI1;GNAI3 Guanine nucleotide-binding protein G(i) subunit alpha-2;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(k) subunit alpha 0 6840700.0 2370600.0 1864400.0 2605700.0 False True 3247074.883056178 1782024.6432536698 1990287.3260760235 1.0 0.5488092228955346 0.6129477753844549 21.630709225327315 -10.486858853289148 6.148904890298994 1.0002931459066031 0.5808784991400703 0.9827393143937475 0.026184454406428553 0.00010529873561823804 8.787424389579923e-06 0.0253702822468097 0.008450996320468756 3.2594261589363774e-11 10.486858853289148 -0.41941464676653284 EK(ub)AEELAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKAEELAAR 9 1 Q04323;E9PJ81;Q04323-2;A0A087WTZ5;E9PS08 Q04323 UBXN1 UBX domain-containing protein 1 1 19281600.0 5557700.0 10185500.0 3538400.0 True False 7286198.520843352 8665863.102768026 3172280.3107295046 1.0 1.1893531418308079 0.4353820859608316 22.796734872822995 -6.840166389939979 1.2814553401799127 1.100738589278721 0.41047773691216194 0.9247535810907112 0.08785183271551672 0.16861594212074618 0.5377615114160531 0.05375215784660761 0.12385163786112281 1.4448860898213287e-07 6.840166389939979 -0.690260852366559 down EK(ub)AEELAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKAEELAAR 9 1 Q04323;E9PJ81;Q04323-2;A0A087WTZ5;E9PS08 Q04323 UBXN1 UBX domain-containing protein 1 1 30932100.0 14354800.0 10655900.0 5921400.0 True False 13899114.731420264 14910856.439784402 4370407.701807758 1.0 1.0727918092565276 0.3144378463131927 23.728489661314125 -6.883350312197866 1.0608946282156977 1.0474758864564058 0.25710825216333266 0.9762906723804414 0.05260350143464963 0.1247056459748835 0.2546808615262799 0.03807201988096606 0.09290733652559124 1.308126331694789e-07 6.883350312197866 -0.7903676342930731 down EK(ub)AEELAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKAEELAAR 9 1 Q04323;E9PJ81;Q04323-2;A0A087WTZ5;E9PS08 Q04323 UBXN1 UBX domain-containing protein 1 1 20865900.0 5103700.0 2266300.0 13495900.0 True False 7742686.030448833 1861861.0583172797 10828429.449536897 1.0 0.24046707447458646 1.3985365552668791 22.884402710702545 -6.729804145917804 1.724235000705777 0.5428034913148174 1.3977825696954558 0.5582040863720428 0.31929476612916957 0.3366186108098105 1.9605546952703747 0.14676255998124654 0.36422169390900044 1.8629270727628995e-07 6.729804145917804 0.8549790783806384 EK(ub)AEELAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKAEELAAR 9 1 Q04323;E9PJ81;Q04323-2;A0A087WTZ5;E9PS08 Q04323 UBXN1 UBX domain-containing protein 1 1 15884800.0 5557700.0 7246800.0 3080300.0 True False 7612531.881195184 6926612.414037063 2352796.580769841 1.0 0.909896013854141 0.309068864011174 22.859944934345886 -6.933645054625972 0.7162510447388621 1.008017771066819 0.17343851233331603 0.997207183878412 0.016207379934034278 0.09078923678014242 0.06873156565624762 0.015099862907160273 0.05331707804410162 1.1650778491207154e-07 6.933645054625972 -0.834579258733503 down EK(ub)AEELAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKAEELAAR 9 1 Q04323;E9PJ81;Q04323-2;A0A087WTZ5;E9PS08 Q04323 UBXN1 UBX domain-containing protein 1 1 36496600.0 14354800.0 18967800.0 3174000.0 True False 11936652.225464765 18865616.696586497 3837668.725082122 1.0 1.5804780385860615 0.3215029350436402 23.5088949367484 -6.781312862459097 1.5307143041415006 1.3281004244520112 0.3111013519155787 0.7720927598775138 0.2456172629316881 0.2484994718144269 1.1501392617984378 0.1263711196044089 0.2978623705325245 1.654577588855008e-07 6.781312862459097 -1.0169990725364324 down EK(ub)AEELAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKAEELAAR 9 1 Q04323;E9PJ81;Q04323-2;A0A087WTZ5;E9PS08 Q04323 UBXN1 UBX domain-containing protein 1 1 19506400.0 5103700.0 6829500.0 7573200.0 True False 6606840.258967414 6449432.321387016 6194955.307594038 1.0 0.9761750047813327 0.9376578008202442 22.655529032794995 -6.9639958389474685 0.3751075089571175 1.0027957268246295 0.9096860260978938 0.9998905596026157 0.00026864481324094606 0.07830599012887177 0.016087821543881074 0.000504081678354507 0.003262450569117432 1.0864360329037051e-07 6.9639958389474685 -0.09310970072673563 EK(ub)ASAAK(ub)SSLIHQGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKASAAKSSLIHQGIR 16 2 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 2 28651700.0 4640400.0 7691300.0 16320000.0 True False 6083609.337697527 6543788.020452588 14631362.952494187 1.0 1.0756423789252096 2.405046435481957 22.53649608190956 -6.918609008164501 0.8349918841784673 0.9691713615837717 2.612703567598232 0.9937854673276514 0.050866982641088965 0.09899694363966087 0.10991063716028171 0.04350734765176131 0.1286389836434526 1.2061213130576155e-07 6.918609008164501 1.6435322060144606 up EK(ub)ASAAK(ub)SSLIHQGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKASAAKSSLIHQGIR 16 2 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 2 62432000.0 9990000.0 12480000.0 39962000.0 True False 9672872.918249521 17463329.082340255 29494753.365697533 1.0 1.8053921756164824 3.0492237016833603 23.20551301428377 -6.964768495620269 0.36201004981697876 0.895250286310226 4.002123262488794 0.9999082853556194 0.008072747125282166 0.07803967911166097 0.015137937021098719 0.01662169883892841 0.10611247406429723 1.0845048645397071e-07 6.964768495620269 3.1068729761785683 EK(ub)ASAAK(ub)SSLIHQGIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKASAAKSSLIHQGIR 16 2 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 2 74456000.0 18030000.0 30572000.0 25854000.0 True False 27352828.16956182 25116187.739873763 20743945.56778923 1.0 0.9182300120549515 0.758383938918355 24.70518667365559 -6.960489284435138 0.4284834538189307 1.0064524096805514 0.6640470358473544 0.9997879117953121 0.001461284123107731 0.07952682448186696 0.020489019733683042 0.002081400044062645 0.013276910259931572 1.0952435785256986e-07 6.960489284435138 -0.342405373833197 EK(ub)ASAAK(ub)SSLIHQGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKASAAKSSLIHQGIR 16 2 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 2 33846600.0 4640400.0 8514200.0 20692000.0 True False 6356081.282094786 8138014.491305712 15804975.765116919 1.0 1.2803509159378859 2.486591197258579 22.599706143432453 -6.943202570165336 0.6290628388788252 0.9868417340308014 2.8450059636886516 0.9985540196800745 0.024524640539644257 0.08633547603616021 0.04818082450580673 0.024497882957342308 0.1024444521426498 1.1397180591205206e-07 6.943202570165336 1.85816422965785 up EK(ub)ASAAK(ub)SSLIHQGIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKASAAKSSLIHQGIR 16 2 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 2 50722000.0 9990000.0 17926000.0 22806000.0 True False 8307127.632038957 17829429.07996761 27574629.156970087 1.0 2.1462808650252354 3.31939394437858 22.985918289718047 -6.970836076401805 0.23736825068822767 0.5647782765612308 4.9347172144898215 0.9999881895537575 0.0032541760975442306 0.07603231889185771 0.008053033100705306 0.028571995954145966 0.11490986246191906 1.0694584680467364e-07 6.970836076401805 4.369938937928591 EK(ub)ASAAK(ub)SSLIHQGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKASAAKSSLIHQGIR 16 2 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 2 77424000.0 18030000.0 35405000.0 23989000.0 True False 23340190.42443377 33434680.626503684 19623248.147926006 1.0 1.4324939093685567 0.840749273724148 24.47631299574804 -6.710766895902738 1.7924718620573534 1.2656780732517188 0.8421075272511559 0.4687531776780389 0.18222860440144348 0.3735313856768158 2.339940629093998 0.08088845707639095 0.20530376827947136 1.946404518392947e-07 6.710766895902738 -0.4235705460005629 EK(ub)ASIYQNQNSS ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKASIYQNQNSS 12 1 J3KMZ8;Q92785;Q92785-2;H0YEI1 J3KMZ8 DPF2 Zinc finger protein ubi-d4 1 5366600.0 1017800.0 2069100.0 2279700.0 True False 1317562.1638374173 1953952.7661149225 1864817.9916973156 1.0 1.483006130370357 1.4153548446367104 20.329439600518167 -10.601412165271231 6.297237777462084 0.9986119119010126 1.4491804875033687 0.9832719515109207 0.027618521748443703 0.0005396776996151246 3.415925129187851e-05 0.0268132657543044 0.008913839564882462 2.5037319693026553e-11 10.601412165271231 0.4505685756023561 EK(ub)DEMVEQEFNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKDEMVEQEFNR 12 1 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 1 6909700.0 3382400.0 1152800.0 2374500.0 True False 3275027.563432157 1613119.0517725835 1752547.216526923 1.0 0.4925512901888588 0.5351244173011759 21.643075618099314 -9.838892263863332 6.718332155774758 1.0000000076927673 0.5138378548773562 0.9942815344791341 0.01738040636339201 2.0134765606716735e-09 3.3592840076706247e-10 0.016828506349658795 0.005609502032964923 1.4491312973108214e-10 9.838892263863332 -0.4861621528154111 EK(ub)DEMVEQEFNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKDEMVEQEFNR 12 1 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 1 7319800.0 3382400.0 2400300.0 1537100.0 True False 2812615.46572659 2387369.1074777525 1858500.503252595 1.0 0.8488075019743296 0.6607730512398658 21.42348089353359 -6.968183958915558 0.2983914766390945 1.033241171523875 0.47046090813393915 0.9999645487177874 0.0008261752497477293 0.07689647588412137 0.011128067404789813 0.0031447109275892933 0.01689293868337841 1.076009339913709e-07 6.968183958915558 -0.5627802633899358 EK(ub)DPEIFCDPFTSATTTTNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKDPEIFCDPFTSATTTTNK 20 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 563664300.0 231318800.0 212145100.0 120200400.0 True False 303261186.89444596 180493878.01512304 107763215.6516533 1.0 0.5951763226394887 0.3553478661585589 28.175985624492363 -8.976141836231575 0.16365677975034662 1.465914712562514 8.635405252905123e-11 0.9997933047636187 0.0038247681289669657 0.4509667514771688 0.05240462336712302 0.2650933474223539 0.15990194757470083 1.056472419545765e-09 8.976141836231575 -1.46591471247616 EK(ub)DPEIFCDPFTSATTTTNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKDPEIFCDPFTSATTTTNK 20 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 275246060.0 146691400.0 81640660.0 46914000.0 True False 142034761.8018128 114240201.2884176 34625816.010168016 1.0 0.804311563163825 0.24378409602631576 27.08166881940358 -6.952485664614633 0.5308532524433611 1.008786562879803 0.013826127843557934 0.9993821952661012 0.007965662146764696 0.08250269794138668 0.031948278178882045 0.008875740563003692 0.04635780554793035 1.1156149754582622e-07 6.952485664614633 -0.994960435036245 down EK(ub)DPEIFCDPFTSATTTTNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKDPEIFCDPFTSATTTTNK 20 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 732418100.0 344967000.0 284561100.0 102890000.0 True False 523340159.4658467 233778948.41897807 82553746.401711 1.0 0.44670553977280725 0.15774395468899322 28.963173730146273 -8.865007884181502 0.2771570762711195 1.2551319336269393 2.4783106633912978e-23 0.998912073083961 0.011526118730315681 0.3707127993675771 0.08968531166769593 0.19820371357451494 0.10326919979116062 1.3645583641731655e-09 8.865007884181502 -1.2551319336269393 EK(ub)DPEIFCDPFTSATTTTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKDPEIFCDPFTSATTTTNK 20 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 545015800.0 231318800.0 196537000.0 117160000.0 True False 316843611.51552176 187853345.47905287 89489220.9859412 1.0 0.5928898000515632 0.2824397202073845 28.239195686015254 -7.910292403059301 0.25134117786366783 1.1665503942577808 3.1342135170925826e-10 0.9996528635668959 0.005474470351470904 0.11129643149645013 0.04220412680963085 0.058424818284812524 0.0915777433443723 1.229440730639163e-08 7.910292403059301 -1.1665503939443596 down EK(ub)DPEIFCDPFTSATTTTNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKDPEIFCDPFTSATTTTNK 20 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 310101800.0 146691400.0 65649000.0 97761400.0 True False 121980398.63087901 65295335.80669383 118202856.74235782 1.0 0.5352936745540728 0.9690315662932674 26.862074094837855 -10.546586748907169 9.247487017226879 1.0000158940163582 0.7521626204236701 0.30329563325550135 0.17707275281192625 5.80281139742381e-05 2.8453932016545186e-06 0.17146092987949854 0.057149985225641076 2.8406207235803724e-11 10.546586748907169 -0.24785327359268805 EK(ub)DPEIFCDPFTSATTTTNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKDPEIFCDPFTSATTTTNK 20 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 698124000.0 344967000.0 259661000.0 93496000.0 True False 446566581.81617475 245210637.0896367 76480687.34997247 1.0 0.549102075870459 0.17126379461474142 28.734300052238723 -7.904942529957097 0.3524006645572333 1.07961855690433 1.5336173385386139e-12 0.9986225542572148 0.012573022926073565 0.10664336164779895 0.06619659001887795 0.044079961169024455 0.08346837805956107 1.2446793088688217e-08 7.904942529957097 -1.0796185569027963 down EK(ub)DTAVQGNIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKDTAVQGNIR 11 1 Q9UBV8 Q9UBV8 PEF1 Peflin 1 2827410.0 1110600.0 1196600.0 520210.0 True False 1456007.355065699 1018071.9443102675 466383.6594066797 1.0 0.699221704319158 0.3203168292962608 20.473586212697327 -7.0947256576055855 0.3227005534847872 1.05473616186786 8.344753205962484e-15 0.9999388994785582 0.0021737323563969734 0.0758368782024059 0.01379278581822048 0.006691858655540547 0.03356677612049038 8.040338673451858e-08 7.0947256576055855 -1.0547361618678515 down EK(ub)DTAVQGNIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKDTAVQGNIR 11 1 Q9UBV8 Q9UBV8 PEF1 Peflin 1 8382900.0 0.0 1912500.0 6470400.0 True False 0.0 1571199.4325692973 5191522.603922931 0.0 EK(ub)DTAVQGNIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKDTAVQGNIR 11 1 Q9UBV8 Q9UBV8 PEF1 Peflin 1 8074720.0 0.0 2081120.0 5993600.0 True False 0.0 1965303.8425484935 4902826.299529347 0.0 EK(ub)EALEQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKEALEQQR 9 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 14413400.0 4153400.0 6428300.0 3831700.0 True False 5445147.621582813 5469222.697317148 3435232.4402617635 1.0 1.0044213816424203 0.6308795792139056 22.376539731221087 -6.904221572481553 0.9341845862781644 1.01378335938531 0.588126220899849 0.9885523031571015 0.018729975459202235 0.10836451058736818 0.16040941794758928 0.014909214639380263 0.039681370273047106 1.246747274595374e-07 6.904221572481553 -0.42565713848546105 EK(ub)EALEQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKEALEQQR 9 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 13731800.0 5431200.0 4963500.0 3337100.0 True False 5258789.528888576 6945451.434310564 2463013.3991459194 1.0 1.3207319661980192 0.4683612807882173 22.326299326704678 -6.804792527975182 1.4364302355689873 1.175904077178661 0.45517897097784515 0.8457463564848605 0.13805671811129405 0.21399911819362866 0.8711867008361158 0.07559552739037452 0.17530664586091416 1.567499720358746e-07 6.804792527975182 -0.720725106200816 down EK(ub)EALEQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKEALEQQR 9 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 9813580.0 4404100.0 1800780.0 3608700.0 True False 6681341.682837886 1479416.7394416411 2895438.863250599 1.0 0.2214250983813272 0.4333618905747636 22.67170640927132 -10.260743688335397 5.253097322586191 1.0000879778803007 0.32739349448289967 0.9306957924217248 0.08652283309973084 8.916198736991709e-05 1.2547612997784628e-05 0.08378623347318807 0.027925124305109135 5.486006422053951e-11 10.260743688335397 -0.672694483397401 EK(ub)EALEQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKEALEQQR 9 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 12876200.0 4153400.0 5034700.0 3688100.0 True False 5689024.22141463 4812250.306473534 2817046.738803775 1.0 0.8458832515353435 0.4951722174428165 22.439749792743978 -6.957443811732545 0.47007601261174425 1.0092564051134703 0.3174197918628704 0.999663329250111 0.003875953045689511 0.08062720410169863 0.024603407414618916 0.004849843554942118 0.028945948907721456 1.1029509224979347e-07 6.957443811732545 -0.6918366132505999 down EK(ub)EALEQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKEALEQQR 9 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 11858340.0 5431200.0 5789500.0 637640.0 True False 4516283.4429559605 5758310.814374228 770967.5758857487 1.0 1.2750109436455888 0.1707084122650064 22.106704602138954 -6.840770410285664 1.2787733324989983 1.146288405815935 0.13382025028800473 0.9257789585185735 0.12787512254917982 0.16789875418830127 0.5329929057982751 0.07840081804042719 0.18066317571658383 1.4428779271445057e-07 6.840770410285664 -1.0124681555279302 down EK(ub)EALEQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKEALEQQR 9 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 6276750.0 4404100.0 702150.0 1170500.0 True False 5701194.267789721 663074.7352605445 957481.0103442159 1.0 0.11630453271988046 0.16794393689647397 22.44283273136377 -10.623687411237505 5.935482641552681 1.0050098826817428 0.1421242348673316 0.9972898312481064 0.021081698475666856 0.0013992046268072747 8.871024461770978e-05 0.02043532180934406 0.006804088925501988 2.3785516622953715e-11 10.623687411237505 -0.8628856478144112 EK(ub)EEFASAHFSPVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKEEFASAHFSPVLR 15 1 Q9Y4R8;H3BRS3 Q9Y4R8 TELO2 Telomere length regulation protein TEL2 homolog 1 154351100.0 7459400.0 13978700.0 132913000.0 True False 11316455.15518741 11484091.768918386 106642687.29216272 1.0 1.0148135269774945 9.423683108334346 23.431918773358277 -6.907283400380055 0.9140367838708447 0.7167511050525304 10.449530706467945 0.9898553459014059 0.39960678748031986 0.10624197395432955 0.14871502355200594 0.3228309461913758 0.8752448871139052 1.237988469192426e-07 6.907283400380055 9.732779601415414 up EK(ub)EEFASAHFSPVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKEEFASAHFSPVLR 15 1 Q9Y4R8;H3BRS3 Q9Y4R8 TELO2 Telomere length regulation protein TEL2 homolog 1 9604860.0 333660.0 1684400.0 7586800.0 True False 457023.1188224607 1609977.63843407 5794954.095050698 1.0 3.5227487891252527 12.679783267817264 18.80190762126698 -6.947107997595122 0.5897400603162228 0.8940766511269779 15.769018805269596 0.9989543463213927 0.16226846869852032 0.08466824005331637 0.040931737272048525 0.16827473477990337 0.7670717387337059 1.1295149991255907e-07 6.947107997595122 14.874942154142618 EK(ub)EEFASAHFSPVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKEEFASAHFSPVLR 15 1 Q9Y4R8;H3BRS3 Q9Y4R8 TELO2 Telomere length regulation protein TEL2 homolog 1 135981000.0 7459400.0 15011600.0 113510000.0 True False 9656340.346756566 14176191.263743073 92852344.71095428 1.0 1.468070796459102 9.615686831309972 23.203045095450726 -6.918711335148513 0.8342261896210307 0.8117404612096347 10.89140238163017 0.9938154091807005 0.31109005885179397 0.09893618096243553 0.1095864052121529 0.2662222286890727 0.7879005558087087 1.2058371643455108e-07 6.918711335148513 10.079661920420536 up EK(ub)EEFAVPENSSVQQFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKEEFAVPENSSVQQFK 17 1 Q9UHD9;Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UHD9;Q9UMX0-2 UBQLN2;UBQLN1 Ubiquilin-2;Ubiquilin-1 1 866624100.0 321865000.0 282019100.0 262740000.0 True False 421968131.9450937 239942949.5818419 235554185.18004465 1.0 0.5686281295125462 0.5582274284416693 28.652558806323214 EK(ub)EEFAVPENSSVQQFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKEEFAVPENSSVQQFK 17 1 Q9UHD9;Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UHD9;Q9UMX0-2 UBQLN2;UBQLN1 Ubiquilin-2;Ubiquilin-1 1 1233860800.0 368008600.0 575923000.0 289929200.0 True False 356326368.4307227 805892057.2987683 213988044.83043906 1.0 2.2616683150560903 0.6005394598576916 28.40862400708499 -6.703614983476786 1.8178251450539513 1.7806433245229083 0.6051045889789809 0.43482922220513864 0.5322206942151428 0.3880445322135514 2.4953429704831467 0.2333466842074796 0.5974766985203661 1.9787230666652465e-07 6.703614983476786 -1.1755387355439275 EK(ub)EEFAVPENSSVQQFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKEEFAVPENSSVQQFK 17 1 Q9UHD9;Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UHD9;Q9UMX0-2 UBQLN2;UBQLN1 Ubiquilin-2;Ubiquilin-1 1 2210845500.0 966963000.0 814465000.0 429417500.0 True False 1466953565.4644477 669117357.3059094 344542942.90462387 1.0 0.45612715566362333 0.2348696993660731 30.45017605905727 -11.346502623969442 0.1667356053956063 2.141557539639871 7.406368409646672e-22 0.9995418450132296 0.0068812538417003894 3.8490759143558133 0.10087256236186071 1.7978159728229133 0.17835414281785814 4.502952606351159e-12 11.346502623969442 -2.141557539639871 EK(ub)EEFAVPENSSVQQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKEEFAVPENSSVQQFK 17 1 Q9UHD9;Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UHD9;Q9UMX0-2 UBQLN2;UBQLN1 Ubiquilin-2;Ubiquilin-1 1 811216800.0 321865000.0 263148700.0 226203100.0 True False 440867188.5745703 251521920.31761762 172778586.57907984 1.0 0.5705163070330739 0.3919062045368234 28.715768867846105 -13.99999999999998 0.12035990104844255 3.0464527893992788 0.1082112540452978 0.9996911775979836 0.004484684914196624 11.962399882935776 0.10681719295576658 5.852857625846003 0.25175377662689236 1.000000000000045e-14 13.99999999999998 -2.938241535353981 EK(ub)EEFAVPENSSVQQFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKEEFAVPENSSVQQFK 17 1 Q9UHD9;Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UHD9;Q9UMX0-2 UBQLN2;UBQLN1 Ubiquilin-2;Ubiquilin-1 1 927010300.0 368008600.0 428345000.0 130656700.0 True False 306015456.4452424 426037420.4651742 157976411.88167533 1.0 1.3922088296262518 0.5162367081609919 28.189029282519265 -6.784944366389792 1.5161549706773807 1.220648184020919 0.5081317562371714 0.7846609635487869 0.1662513978022838 0.2429526282265267 1.103261919140519 0.08633207355153827 0.20292099618955778 1.6407999480509947e-07 6.784944366389792 -0.7125164277837475 EK(ub)EEFAVPENSSVQQFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKEEFAVPENSSVQQFK 17 1 Q9UHD9;Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UHD9;Q9UMX0-2 UBQLN2;UBQLN1 Ubiquilin-2;Ubiquilin-1 1 2305989000.0 966963000.0 962461000.0 376565000.0 True False 1251752665.1903353 908899199.2787844 308034033.8831862 1.0 0.7261012694872766 0.24608218735955165 30.22130238114972 -7.102715377666868 0.4333614485645483 1.0199403134417386 8.964883898132645e-14 0.9997338055403958 0.005083837623326372 0.07658072426242833 0.02292465703325126 0.00720283010537084 0.03883736131145748 7.893772800659313e-08 7.102715377666868 -1.019940313441649 down EK(ub)EEFAVPENSSVQQFKEEISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKEEFAVPENSSVQQFKEEISK 22 2 Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UMX0-2 UBQLN1 Ubiquilin-1 1 108085000.0 48848000.0 39877000.0 19360000.0 True False 74105987.26715215 32760637.789576907 15533487.514210554 1.0 0.4420781504667738 0.20961177479779491 26.143086771542663 -10.516006769276553 0.19021100499155208 1.808290885350453 1.1531524527643373e-23 0.9994480207031873 0.007792277438965759 2.271197694864964 0.09785239239167604 1.0132739987220105 0.15099103989491064 3.047847482961068e-11 10.516006769276553 -1.808290885350453 EK(ub)EEFAVPENSSVQQFKEEISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKEEFAVPENSSVQQFKEEISK 22 2 Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UMX0-2 UBQLN1 Ubiquilin-1 1 114879000.0 48848000.0 49792000.0 16239000.0 True False 63234698.93803321 47021031.42931426 13283668.6262108 1.0 0.7435954028245234 0.21006929501203317 25.914213093635112 -7.111989629070647 0.4935663334999461 1.0111555343703778 3.036269573570767e-14 0.9994795472421255 0.007506445459759466 0.0775046388911586 0.029906477856517778 0.008856944910812778 0.042194958969894635 7.7269903688769e-08 7.111989629070647 -1.0111555343703473 down EK(ub)EGSRGEEDTGQEEGGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKEGSRGEEDTGQEEGGSR 19 2 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 1993590.0 538020.0 625800.0 829770.0 True False 520940.8495972587 875685.203503887 612428.3444335837 1.0 1.6809685863200832 1.17561973668806 18.990760044949674 -10.619498092204468 4.905823959875982 0.9941780726984064 1.4282941615040787 0.4892028319810149 0.2063078039501782 0.013258018727105069 0.0010283079076233135 0.20159688893091604 0.06658555740763518 2.4016068177887776e-11 10.619498092204468 0.4341160888056723 EK(ub)EGSRGEEDTGQEEGGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKEGSRGEEDTGQEEGGSR 19 2 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 4980800.0 1257700.0 2181200.0 1541900.0 True False 1722705.6780645228 2084827.3717361654 1177734.976427302 1.0 1.2102052012033129 0.6836542024697446 20.716244809443463 -6.798367909280686 1.4625191025309776 1.1162218368671775 0.6766715791789991 0.8273541145477216 0.08992166257528744 0.22310039985558752 0.9422702683298219 0.04837262019401919 0.1126129757906542 1.5908604706518102e-07 6.798367909280686 -0.43955025768817835 EK(ub)EGSRGEEDTGQEEGGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKEGSRGEEDTGQEEGGSR 19 2 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 1709320.0 538020.0 811190.0 360110.0 True False 447387.46832728793 806819.9584613917 435407.3360394852 1.0 1.8034031249868618 0.9732220208746691 18.77116532038395 -6.653680947717428 1.9959304640508293 1.5198156837352916 0.9767452642322745 0.2089534903213459 0.34259519109092634 0.49953502335087796 3.8186927202929772 0.13902539744087955 0.3794305581878332 2.2198266055056e-07 6.653680947717428 -0.5430704195030172 EK(ub)EKPSYDTETDPSEGLMNVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKEKPSYDTETDPSEGLMNVLK 22 2 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 20363500.0 6989500.0 9406800.0 3967200.0 True False 6767622.148358871 13162984.295813955 2928071.3065511053 1.0 1.9449939738444086 0.43265880428344455 22.69021759110557 -6.737753363611428 1.6949348888538036 1.5637262851407154 0.43220178026163036 0.5948085446272747 0.3970725717820645 0.32189643172568544 1.814859475131182 0.18539832278294913 0.45607534057907434 1.8291386914281226e-07 6.737753363611428 -1.131524504879085 EK(ub)ELLIDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKELLIDK 8 1 H7BZW2;Q6P2H3-4;Q6P2H3-2;Q6P2H3 H7BZW2 CEP85 Centrosomal protein of 85 kDa 1 12988500.0 2570700.0 3848300.0 6569500.0 True False 3899939.8433440123 3161540.7980948617 5271035.445485866 1.0 0.8106639910076129 1.3515683977746191 21.895020439868645 -6.812145193954157 1.405576547703169 0.8970713323965449 1.361494957671276 0.865326324618789 0.08224354611516455 0.20389684479466913 0.7935348612856828 0.04600384211306142 0.106312695603615 1.5411851155916235e-07 6.812145193954157 0.46442362527473113 EK(ub)ELLIDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKELLIDK 8 1 H7BZW2;Q6P2H3-4;Q6P2H3-2;Q6P2H3 H7BZW2 CEP85 Centrosomal protein of 85 kDa 1 12389400.0 2570700.0 3470200.0 6348500.0 True False 3327821.8260727604 3277080.3194490396 5193138.141110854 1.0 0.9847523367308394 1.5605216903212022 21.666146761961095 -6.900820394951717 0.9560980180451486 0.9765968502312357 1.621968606427312 0.9869689048833266 0.030581659641937212 0.1108035769206218 0.17404804599293777 0.023952731197111134 0.06257921342968684 1.256549509728743e-07 6.900820394951717 0.6453717561960763 EK(ub)ELLIHER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKELLIHER 9 1 Q96BN8 Q96BN8 OTULIN Ubiquitin thioesterase otulin 1 44632000.0 19122000.0 13942000.0 11568000.0 True False 25069127.17771144 11861907.945490343 10371054.328091484 1.0 0.4731679671734474 0.4136982613942867 24.57940843149197 -13.999999999999998 0.30793604635624605 6.031522478554045 0.40023482980783603 0.999667450121815 0.004804969908589862 17.12417548766383 0.17649064498978403 55.143527300199814 0.02078433251044042 1.0000000000000041e-14 13.999999999999998 -5.631287648746209 EK(ub)ELLIHER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKELLIHER 9 1 Q96BN8 Q96BN8 OTULIN Ubiquitin thioesterase otulin 1 103840000.0 34229000.0 50624000.0 18987000.0 True False 51927895.475093186 41589751.67288266 15234211.127702283 1.0 0.8009134838293391 0.2933723962491269 25.63000642152304 -6.955041387177466 0.5004487240082875 1.0101250531636232 0.06225347103687118 0.9995398171651431 0.006381928331901882 0.08152234005514102 0.02805673902829922 0.007478054232193527 0.041868188281831586 1.1090691187141905e-07 6.955041387177466 -0.947871582126752 down EK(ub)ELLIHER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKELLIHER 9 1 Q96BN8 Q96BN8 OTULIN Ubiquitin thioesterase otulin 1 46775000.0 19122000.0 15428000.0 12225000.0 True False 26191920.152619712 14746339.946426516 9337706.781778185 1.0 0.5630110301382997 0.35651096702218027 24.64261849301486 -12.073713531703373 0.12190207189530834 2.351033855566758 8.85127060461288e-19 0.9997507449338839 0.004235264183281811 5.702008746492773 0.08696028461178369 2.2375043585571577 0.27128628036608315 8.438912197438972e-13 12.073713531703373 -2.351033855566758 EK(ub)ELLIHER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKELLIHER 9 1 Q96BN8 Q96BN8 OTULIN Ubiquitin thioesterase otulin 1 49852000.0 12640000.0 26471000.0 10741000.0 True False 10510720.046944188 26328395.468917906 12986893.4392272 1.0 2.5049088313005194 1.2355855147148473 23.32535817010273 -6.604459328942674 2.1738648624204253 2.0091324418526226 1.2398721667411556 0.033604775759624506 0.6497279678094732 0.628121274525047 5.616263323604613 0.2474971086635099 0.7221772402655756 2.486226384872817e-07 6.604459328942674 -0.769260275111467 EK(ub)ELLIHER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKELLIHER 9 1 Q96BN8 Q96BN8 OTULIN Ubiquitin thioesterase otulin 1 87418500.0 34229000.0 43512000.0 9677500.0 True False 44310115.25446159 41090518.949877925 7916294.29953538 1.0 0.9273394734792643 0.1786565946415201 25.401132743615488 -6.925713192962957 0.7811868923377053 1.0133747337648455 0.0404938691157468 0.9956262773225364 0.02455201202150947 0.09492607260391189 0.08904135906431597 0.021821669111487113 0.06940827917458457 1.1865520856407914e-07 6.925713192962957 -0.9728808646490987 down EK(ub)FYEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKFYEAK 7 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 7350300.0 2675000.0 3476500.0 1198800.0 True False 3506950.9047368495 2957819.7512908587 1074759.6757015968 1.0 0.8434163555856236 0.3064655607952525 21.74178580316883 -6.948412711550443 0.5760048901158538 1.0065191261710082 0.1169859278787165 0.9990707710501265 0.009053203919989636 0.08412942337330127 0.038648775945472724 0.00952690063207934 0.04480672980152256 1.1261267853402461e-07 6.948412711550443 -0.8895331982922917 down EK(ub)FYEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKFYEAK 7 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 10859400.0 3425900.0 4564000.0 2869500.0 True False 3317146.679742851 6386429.000945584 2117891.866845233 1.0 1.9252778419315082 0.6384679579527711 21.66151137688541 -6.713744610336008 1.7819715488410932 1.5666498582533661 0.6411581690633134 0.48284506710174135 0.3896861765400109 0.3675826249931092 2.2775692861856194 0.17388192089773385 0.43972862306072386 1.9331047575273375e-07 6.713744610336008 -0.9254916891900528 EK(ub)FYEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKFYEAK 7 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 6608600.0 2675000.0 2350000.0 1583600.0 True False 3664019.78915687 2246169.229589207 1209586.2952657624 1.0 0.6130341425110246 0.3301254809936769 21.804995864691723 -7.951844386325597 0.2156438614705235 1.2195997344090908 7.829923949773382e-14 0.999801211656004 0.0038712606127033005 0.10863289517272216 0.03645470315824626 0.06970102150118597 0.09803243385117433 1.1172635069182527e-08 7.951844386325597 -1.2195997344090124 down EK(ub)GSETDSAQDQPVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKGSETDSAQDQPVK 15 1 P30419;B7Z8J4;K7EN42 P30419 NMT1 Glycylpeptide N-tetradecanoyltransferase 1 1 4208330.0 2607300.0 776560.0 824470.0 True False 3955464.7191624166 637976.8007090274 661513.1431219616 1.0 0.1612899737465289 0.1672403093161805 21.915415773161236 -10.092712660624272 4.698572707930669 1.0000455465565448 0.1642651415169666 0.9999619816638559 0.0024292143744712425 1764919.052981855 541587.8015623724 819.3924401881001 0.0008315846619792406 8.077692925251416e-11 10.092712660624272 -0.8357804050395782 EK(ub)GSTLDLSDLEAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKGSTLDLSDLEAEK 15 1 O00767 O00767 SCD Acyl-CoA desaturase 1 47509500.0 0.0 8478500.0 39031000.0 True False 0.0 7213540.848934153 34992446.53178929 0.0 EK(ub)GSTLDLSDLEAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKGSTLDLSDLEAEK 15 1 O00767 O00767 SCD Acyl-CoA desaturase 1 144029200.0 9282200.0 11490000.0 123257000.0 True False 8987541.641819388 16078016.91955843 90972294.06926039 1.0 1.788922662093356 10.122044235763282 23.099495119305278 -6.925318880175101 0.7842704664937301 0.8489172400993009 11.6452388225541 0.995535379217894 0.27574440120230903 0.09514235805412108 0.09013105487487073 0.2445415884657427 0.774315452693953 1.1876298914718246e-07 6.925318880175101 10.7963215824548 up EK(ub)GSTLDLSDLEAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKGSTLDLSDLEAEK 15 1 O00767 O00767 SCD Acyl-CoA desaturase 1 431358900.0 9620900.0 167917000.0 253821000.0 True False 14595608.68200426 137950899.40849066 203653168.0963037 1.0 9.45153452754444 13.953043859513652 23.79903104114957 -8.461417334407576 0.4117362695648047 2.304415786963746e-19 14.938580678547376 0.9964487740957639 0.31997370436028316 0.1806023577501205 0.12811841844990987 1.2577725458023716 1.0925977327133158 3.456071077505317e-09 8.461417334407576 14.938580678547376 EK(ub)GSTLDLSDLEAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKGSTLDLSDLEAEK 15 1 O00767 O00767 SCD Acyl-CoA desaturase 1 76773000.0 0.0 11178000.0 65595000.0 True False 0.0 10684118.999297088 50102811.97143064 0.0 EK(ub)GSTLDLSDLEAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKGSTLDLSDLEAEK 15 1 O00767 O00767 SCD Acyl-CoA desaturase 1 89919700.0 9282200.0 15292400.0 65345100.0 True False 7718560.571182382 15210016.805896271 79008458.28839453 1.0 1.9705768537573705 10.236164834072355 22.879900394739554 -6.928951768651361 0.7553499903363357 0.8692956241879104 11.888605438424943 0.9963281460999898 0.2511205336361818 0.09318574884665946 0.08037433469486147 0.2273724732722288 0.7522500532542981 1.1777367619158417e-07 6.928951768651361 11.019309814237033 EK(ub)GSTLDLSDLEAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKGSTLDLSDLEAEK 15 1 O00767 O00767 SCD Acyl-CoA desaturase 1 372054900.0 9620900.0 106112000.0 256322000.0 True False 12454444.706291428 100206773.9200554 209674026.08581823 1.0 8.045864451061028 16.83527696581288 23.570157363242018 -7.168194386886441 0.3407748892375474 1.2902974960277037e-23 23.421739160804435 0.9998232676272417 0.08611599589974646 0.10006255639626917 0.0212459131171944 0.21481489113876362 1.0319911440994485 6.788996942944837e-08 7.168194386886441 23.421739160804435 EK(ub)GSTLDLSDLEAEK(ub)LVMFQR ddPTM_RPMI8226_Bortezomib_2h_R1 2 EKGSTLDLSDLEAEKLVMFQR 21 2 O00767 O00767 SCD Acyl-CoA desaturase 2 130873800.0 7508000.0 15002600.0 108363200.0 True False 7269662.649671418 20993216.417525437 79979627.09368293 1.0 2.8877841282599697 11.001834740886903 22.793456986434865 -6.943226188351621 0.6288336266743025 0.9114868893547656 13.414561747301743 0.9985566706677652 0.16484173821095036 0.08632516449473107 0.048135293453482886 0.1646953329158139 0.6890526816308533 1.139656079651229e-07 6.943226188351621 12.503074857946977 EK(ub)GSTLDLSDLEAEK(ub)LVMFQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKGSTLDLSDLEAEKLVMFQR 21 2 O00767 O00767 SCD Acyl-CoA desaturase 2 300982100.0 14016100.0 146846000.0 140120000.0 True False 21263448.414164998 120640183.98696531 112425220.58322223 1.0 5.673594500626665 5.287252490444039 24.341872250101257 -10.259022321145714 4.469314322354042 0.9978139660431178 5.480423495578555 0.9944543576419489 0.1577234653380432 27879442.289932195 2339.220188761856 627179.4452700479 0.053992937361647245 5.5077938763469705e-11 10.259022321145714 4.482609529535438 EK(ub)GSTLDLSDLEAEK(ub)LVMFQR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 EKGSTLDLSDLEAEKLVMFQR 21 2 O00767 O00767 SCD Acyl-CoA desaturase 2 137351900.0 7508000.0 15794900.0 114049000.0 True False 6243234.66079565 15709809.738657834 137896118.59700423 1.0 2.5162933306523745 22.08728745419774 22.57386226186914 -6.9223690931284185 0.8069575255072532 0.6039323656344784 25.421962274609296 0.9948141641903455 0.691554315536237 0.09679789188340109 0.09853641816660218 0.6034449718421067 1.850666265304642 1.195723891490154e-07 6.9223690931284185 24.818029908974818 up EK(ub)GSTLDLSDLEAEK(ub)LVMFQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKGSTLDLSDLEAEKLVMFQR 21 2 O00767 O00767 SCD Acyl-CoA desaturase 2 241242100.0 14016100.0 107225000.0 120001000.0 True False 18144117.74863593 101257834.49164967 98162049.31423861 1.0 5.580752720768813 5.410130747284112 24.112998572193707 -10.342822790698406 4.570803845240328 0.9955440095193508 5.495441734037002 0.9989207613701542 0.06965612902663694 0.0031590340878077795 0.000454196901003993 0.06735989641677899 0.022481418968391228 4.5412688055368506e-11 10.342822790698406 4.499897724517652 EK(ub)HISIEEEHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKHISIEEEHLR 12 1 Q6ZU80;H0YJE3;Q6ZU80-1 Q6ZU80 CEP128 Centrosomal protein of 128 kDa 1 7308000.0 1900700.0 2261400.0 3145900.0 True False 1840363.3188905779 3164388.8130452097 2321894.4150229697 1.0 1.7194370158131553 1.2616500183358752 20.811559176160497 -10.23365461748548 4.736765878833209 0.9998850065005438 1.4905435170760266 0.6048946927591954 0.1868907591219495 0.00022701344593883315 3.6727677004924766e-05 0.1809983276055585 0.060318733135867816 5.839092867472256e-11 10.23365461748548 0.4906585105754828 EK(ub)HISIEEEHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKHISIEEEHLR 12 1 Q6ZU80;H0YJE3;Q6ZU80-1 Q6ZU80 CEP128 Centrosomal protein of 128 kDa 1 11116500.0 3866200.0 4493100.0 2757200.0 True False 5865308.057080408 3691271.2002494717 2212238.2114763116 1.0 0.6293396978174898 0.3771734050363766 22.483775452642032 -8.180039850894435 0.1783240868794429 1.3137293630289977 3.2674025363740156e-16 0.9998689814963851 0.002927933839298954 0.08636347897753716 0.035746025162563394 0.10764078947021391 0.11824540666780459 6.606328255083507e-09 8.180039850894435 -1.3137293630289975 down EK(ub)HISIEEEHLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKHISIEEEHLR 12 1 Q6ZU80;H0YJE3;Q6ZU80-1 Q6ZU80 CEP128 Centrosomal protein of 128 kDa 1 6651120.0 1900700.0 4270400.0 480020.0 True False 1580516.2652869322 4247394.507591966 580389.9626382864 1.0 2.6873462810083004 0.367215431682331 20.591964451594773 -6.711638557101859 1.7891509116286783 2.0355591694267865 0.3723247206888113 0.47305801517485124 0.7108527673543403 0.37174747094190025 2.320627285232818 0.3160453282521521 0.8013763995329338 1.9425018581028545e-07 6.711638557101859 -1.6632344487379753 EK(ub)HISIEEEHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKHISIEEEHLR 12 1 Q6ZU80;H0YJE3;Q6ZU80-1 Q6ZU80 CEP128 Centrosomal protein of 128 kDa 1 12395100.0 3866200.0 5777500.0 2751400.0 True False 5004872.114195547 5455977.046169325 2250673.4317480386 1.0 1.0901331585864678 0.4496964918173136 22.25490177473448 -6.87126818619524 1.1274312551301946 1.051383525071159 0.41128497283608795 0.9659292625727727 0.05224832774373778 0.13564128842076043 0.3214759183493042 0.03593870752028567 0.0852745702735022 1.34502951286137e-07 6.87126818619524 -0.6400985522350711 down EK(ub)IDFQHAHGLQELEFIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKIDFQHAHGLQELEFIR 18 1 E9PH99;Q9Y4E5-2;Q9Y4E5;D6RIA1 E9PH99 ZNF451 Zinc finger protein 451 1 67802000.0 9888000.0 37987000.0 19927000.0 True False 12963263.755528226 32319487.67216624 17865145.193281356 1.0 2.4931597691502256 1.3781363652083918 23.627925654897336 -10.440436539876444 5.19509157080158 0.9988409207064463 1.9356480671785186 0.48423011796788895 0.45520639848653194 0.0061176648459135225 0.0006589314811117261 0.4412119475085958 0.1469172333687713 3.6271328288444606e-11 10.440436539876444 0.9368071464720723 EK(ub)IDFQHAHGLQELEFIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKIDFQHAHGLQELEFIR 18 1 E9PH99;Q9Y4E5-2;Q9Y4E5;D6RIA1 E9PH99 ZNF451 Zinc finger protein 451 1 184799000.0 45528000.0 46000000.0 93271000.0 True False 44082738.56076719 64368039.88683096 68840527.02997789 1.0 1.4601642726461035 1.5616209264105172 25.393710515736622 -11.86390673318344 0.2525292497634487 1.1077550613507523e-09 1.6058165728867655 0.9993616140858662 0.006174394271113766 4.824420890283803 0.14523929893669998 2.5929239336338 0.04605762222492575 1.3680225834427408e-12 11.86390673318344 1.6058165717790105 EK(ub)IDFQHAHGLQELEFIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKIDFQHAHGLQELEFIR 18 1 E9PH99;Q9Y4E5-2;Q9Y4E5;D6RIA1 E9PH99 ZNF451 Zinc finger protein 451 1 311175300.0 86661700.0 91877600.0 132636000.0 True False 131472134.71891905 75481324.43703464 106420436.46357614 1.0 0.5741241259861642 0.8094524112740528 26.97018181441265 -10.112987278908909 5.2572207646498725 1.0000066931023972 0.6917882686298282 0.6957822544825581 0.09607237016755302 7.53695249472335e-06 1.2716985032586762e-06 0.09302369141948251 0.031007224140659286 7.709260502329435e-11 10.112987278908909 -0.308218424472569 EK(ub)IDFQHAHGLQELEFIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKIDFQHAHGLQELEFIR 18 1 E9PH99;Q9Y4E5-2;Q9Y4E5;D6RIA1 E9PH99 ZNF451 Zinc finger protein 451 1 69986700.0 9888000.0 39388700.0 20710000.0 True False 13543860.813152589 37648376.99298746 15818724.535838539 1.0 2.7797374406289466 1.1679627215658335 23.691135716420227 -6.622519005337117 2.10795928550009 2.1788364613760685 1.1742541105046336 0.09119640602888324 0.7648637274774196 0.5786601778508843 4.889650708770968 0.29781778767345113 0.8476590888301434 2.384959424003914e-07 6.622519005337117 -1.0045823508714349 EK(ub)IDFQHAHGLQELEFIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKIDFQHAHGLQELEFIR 18 1 E9PH99;Q9Y4E5-2;Q9Y4E5;D6RIA1 E9PH99 ZNF451 Zinc finger protein 451 1 130253800.0 45528000.0 63361800.0 21364000.0 True False 37858549.23237935 63020457.40706741 25831113.62402474 1.0 1.6646294875231984 0.6823059559274427 25.174115791170898 -6.724489807210913 1.7431359284921044 1.4024170488451981 0.6834433718193604 0.5335200399914279 0.2795383420028448 0.34672171668086 2.0612161391265973 0.12721479930633373 0.31768558894714183 1.8858632297363427e-07 6.724489807210913 -0.7189736770258377 EK(ub)IDFQHAHGLQELEFIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKIDFQHAHGLQELEFIR 18 1 E9PH99;Q9Y4E5-2;Q9Y4E5;D6RIA1 E9PH99 ZNF451 Zinc finger protein 451 1 272026700.0 86661700.0 90044000.0 95321000.0 True False 112185279.00749573 85032972.24496257 77973556.07605378 1.0 0.757969075775807 0.6950426719609436 26.7413081365051 -13.999999999999998 0.1891225243687957 2.2935227093505937 0.6494979144221849 0.9994899124427383 0.002969053938023591 12.33657787627205 0.13790894438873363 5.8788673313168 0.04357922439244204 1.0000000000000041e-14 13.999999999999998 -1.6440247949284088 EK(ub)IEDAK(ub)ESQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKIEDAKESQR 11 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 2 6084900.0 1183100.0 2764900.0 2136900.0 True False 1551055.5571566978 2352387.697495785 1915794.0865922072 1.0 1.5166366456969738 1.235155038613914 20.5648189324222 -10.080816745099305 4.513582219062633 0.99997608830222 1.3758958421299252 0.7039485541195009 0.11491438496207075 13332498.328853555 29777341.322436992 2015.7064975221515 0.03933824957284874 8.302010052343632e-11 10.080816745099305 0.37591975382770526 EK(ub)IEDAK(ub)ESQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKIEDAKESQR 11 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 2 6906900.0 2871700.0 1952800.0 2082400.0 True False 2780539.45538911 2732563.223717469 1536956.9693390878 1.0 0.9827457108804352 0.5527549578051233 21.406933378212997 -6.915352298663455 0.8584793642841742 1.0111674350679756 0.49031955326643467 0.9927896616217318 0.01756749210432831 0.10098440334912977 0.12035246612008066 0.014774786664150684 0.04246925772699196 1.2151998334620937e-07 6.915352298663455 -0.520847881801541 EK(ub)IEDAK(ub)ESQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKIEDAKESQR 11 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 2 12052500.0 0.0 4430700.0 7621800.0 True False 0.0 3640006.9677828923 6115347.889246391 0.0 EK(ub)IEDAK(ub)ESQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKIEDAKESQR 11 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 2 6762700.0 1183100.0 2614500.0 2965100.0 True False 1620524.0420753246 2498982.745004672 2264804.4481513696 1.0 1.5420831040583323 1.3975753455968152 20.62802899394509 -10.002916315415499 4.621965322512812 0.9999893097217225 1.4698292247228053 0.9337488212970106 0.05899504545892021 9365361.98911464 10141810.350038575 884.0070026168205 0.020195572906266987 9.933074312613252e-11 10.002916315415499 0.4698399150010828 EK(ub)IEDAK(ub)ESQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKIEDAKESQR 11 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 2 6958870.0 2871700.0 3093700.0 993470.0 True False 2387945.787880513 3077033.6240486316 1201199.983713717 1.0 1.288569296533209 0.5030264882101344 21.187338653647274 -6.807276701911568 1.4259594927370538 1.1577832244533217 0.4901256049704476 0.8525862905464143 0.12456581704379054 0.21054406893334565 0.8442685794575829 0.06869835990431115 0.15911778873691124 1.5585591820843902e-07 6.807276701911568 -0.667657619482874 EK(ub)IEDAK(ub)ESQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKIEDAKESQR 11 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 2 9841700.0 0.0 2885000.0 6956700.0 True False 0.0 2724447.2138811788 5690651.981769854 0.0 EK(ub)IETELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKIETELR 8 1 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;B0AZS6 P63104 YWHAZ 14-3-3 protein zeta/delta 1 4730670.0 3265100.0 1156600.0 308970.0 True False 4280577.719273381 984039.7883914898 277000.7482495179 1.0 0.22988480829604666 0.06471106621947709 22.029374089428224 -12.163455711246225 0.2535288277863958 2.97187819042665 1.1549380055800937e-21 0.9993592624309817 0.010317097797399519 5.80507248732837 0.15289561795473278 6.021137698849147 0.07444204987925315 6.86347867653995e-13 12.163455711246225 -2.97187819042665 EK(ub)IETELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKIETELR 8 1 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;B0AZS6 P63104 YWHAZ 14-3-3 protein zeta/delta 1 12953300.0 4344600.0 5244000.0 3364700.0 True False 4206683.051113808 7337956.547098728 2483384.1311636725 1.0 1.7443568859212841 0.5903425813138322 22.00425169291891 -6.732548631048454 1.7139332924464978 1.446670686944128 0.5907015181198308 0.5710607646256907 0.31285154334431997 0.3314719472875454 1.9087376236480187 0.1445838923879411 0.35774513097274807 1.8511915914825464e-07 6.732548631048454 -0.8559691688242971 EK(ub)IETELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKIETELR 8 1 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;B0AZS6 P63104 YWHAZ 14-3-3 protein zeta/delta 1 11427300.0 3265100.0 4599400.0 3562800.0 True False 4472295.706009759 4396183.299818132 2721340.018169271 1.0 0.9829813565124174 0.608488390987296 22.092584150951115 -6.9164027174904215 0.8509730123007496 1.0093819275988138 0.5528256432460485 0.9931220507423253 0.014984625212062945 0.10033502748710818 0.11692160026570105 0.012670618352044997 0.03674237614831855 1.2122642070689973e-07 6.9164027174904215 -0.4565562843527653 EK(ub)IETELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKIETELR 8 1 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;B0AZS6 P63104 YWHAZ 14-3-3 protein zeta/delta 1 15945810.0 4344600.0 8384900.0 3216310.0 True False 3612727.398414065 8339728.879427658 3888825.55046279 1.0 2.308430158081863 1.0764237435046795 21.784656968353186 -6.632057879723737 2.0736007088244546 1.8607565890043969 1.0814810509193864 0.12471620471120648 0.5609643884962442 0.5536789252388397 4.5398109876230786 0.22109036677645888 0.6211309516890691 2.3331470960723464e-07 6.632057879723737 -0.7792755380850105 EK(ub)IETELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKIETELR 8 1 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;B0AZS6 P63104 YWHAZ 14-3-3 protein zeta/delta 1 37031700.0 14811700.0 16076800.0 6143200.0 True False 19174037.63225655 15182111.947357005 5025200.634554963 1.0 0.7918056821697317 0.2620835908917301 24.192650833177648 -6.9550841331389 0.49993122394392375 1.010615020586431 0.020429873016754314 0.9995421885956502 0.006646600015562556 0.08150631145565419 0.0279943979217846 0.007795754591561835 0.04369712244577043 1.1089599626122307e-07 6.9550841331389 -0.9901851475696767 down EK(ub)IFTYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKIFTYR 7 1 J3KQ25;Q8N6M9 J3KQ25 ZFAND2A AN1-type zinc finger protein 2A 1 45065100.0 1528100.0 16183000.0 27354000.0 True False 2318239.4190741754 13295017.211643895 21947469.91031591 1.0 5.734962964676645 9.467300801519874 21.144598139496917 -7.886314904755174 0.31801887533814416 1.9756300575640505e-20 11.699758446471149 0.9989590904563871 0.11178624974564125 0.11846571299080146 0.06055041344021674 0.5316160911950313 0.9740090871259689 1.2992271732874087e-08 7.886314904755174 11.699758446471149 EK(ub)IFTYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKIFTYR 7 1 J3KQ25;Q8N6M9 J3KQ25 ZFAND2A AN1-type zinc finger protein 2A 1 35713100.0 1528100.0 0.0 34185000.0 True False 1978155.5733542552 0.0 27963680.767720636 1.0 0.0 14.136239406238449 20.915724461589367 -6.8899196215594785 1.022877356665484 0.23897693131026654 15.350087271162302 0.9808461060534418 0.891437667740992 0.11920760471376539 0.22223831211418013 0.6641180465889779 1.6551486932519217 1.288488000665123e-07 6.8899196215594785 15.111110339852035 up EK(ub)IQALPTVPVTEEHVGSGLECPVCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKIQALPTVPVTEEHVGSGLECPVCK 26 1 Q9BV68;K7EIY6 Q9BV68 RNF126 E3 ubiquitin-protein ligase RNF126 1 93567500.0 38803700.0 35722800.0 19041000.0 True False 50872026.47556528 30393097.486383814 17070819.974169247 1.0 0.5974422406974912 0.3355639858846327 25.60036922898447 -8.389860938978892 0.19108790824372862 1.3165948668558998 2.9944653026585677e-06 0.9997799598077438 0.0040536748033287075 0.11550601075688167 0.04497206750787376 0.13496732132563868 0.12502250960854827 4.075107417876886e-09 8.389860938978892 -1.3165918723905972 down EK(ub)IQALPTVPVTEEHVGSGLECPVCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKIQALPTVPVTEEHVGSGLECPVCK 26 1 Q9BV68;K7EIY6 Q9BV68 RNF126 E3 ubiquitin-protein ligase RNF126 1 141350000.0 61897300.0 62183700.0 17269000.0 True False 93902729.39876972 51086532.89153429 13855774.58072841 1.0 0.544036719897554 0.14755454574582305 26.484663756412655 -7.889554161367808 0.3815012035424408 1.0632319656562996 4.471945186614806e-24 0.9981321522019818 0.015052679566607474 0.10705289564258162 0.07333530568863154 0.04052278197520226 0.08161149790405206 1.2895727237621777e-08 7.889554161367808 -1.0632319656562996 down EK(ub)IQALPTVPVTEEHVGSGLECPVCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKIQALPTVPVTEEHVGSGLECPVCK 26 1 Q9BV68;K7EIY6 Q9BV68 RNF126 E3 ubiquitin-protein ligase RNF126 1 91082200.0 38803700.0 34312500.0 17966000.0 True False 53150476.52056309 32796460.29373602 13722800.821384614 1.0 0.6170492240280777 0.25818772887342745 25.66357929050736 -7.59320906997316 0.3060929621224875 1.0896886716617107 7.615191740163737e-15 0.9995782348901643 0.006220565140410979 0.1260667932357968 0.03727970188085806 0.02755715664529814 0.07138933625190277 2.551472724414573e-08 7.59320906997316 -1.0896886716617031 down EK(ub)IQALPTVPVTEEHVGSGLECPVCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKIQALPTVPVTEEHVGSGLECPVCK 26 1 Q9BV68;K7EIY6 Q9BV68 RNF126 E3 ubiquitin-protein ligase RNF126 1 22209600.0 14245500.0 1659900.0 6304200.0 True False 11845764.432653757 1650957.7892356457 7622379.0726725655 1.0 0.1393711481113582 0.6434687365266942 23.497867966007366 -10.200749873816632 5.66458912585999 1.0000180673368853 0.3914199425013846 0.6602479268402235 0.20579697869760188 4.695867803303388e-05 6.625965607493582e-06 0.19926797427880713 0.06642068926628888 6.298688430717338e-11 10.200749873816632 -0.6085981248355006 EK(ub)IQALPTVPVTEEHVGSGLECPVCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKIQALPTVPVTEEHVGSGLECPVCK 26 1 Q9BV68;K7EIY6 Q9BV68 RNF126 E3 ubiquitin-protein ligase RNF126 1 118116300.0 61897300.0 45115000.0 11104000.0 True False 80127275.02819212 42604310.59072776 9083185.936661405 1.0 0.5317079680513007 0.11335947632645141 26.255790078505104 -7.903094653696788 0.42183738251968966 1.0470949011674058 1.6431689940824234e-21 0.9971477483360547 0.019341733625201044 0.10534580293333326 0.08683733763288842 0.03909693253750168 0.08016030548788865 1.2499865682159064e-08 7.903094653696788 -1.0470949011674058 down EK(ub)IQALPTVPVTEEHVGSGLECPVCKDDYALGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKIQALPTVPVTEEHVGSGLECPVCKDDYALGER 34 2 Q9BV68;K7EIY6 Q9BV68 RNF126 E3 ubiquitin-protein ligase RNF126 1 57748500.0 28067500.0 17146000.0 12535000.0 True False 42580449.50910562 14086162.337690562 10057451.755714322 1.0 0.3308129082732747 0.2361988159275675 25.34368784418339 -13.999999999999998 0.27557424514822526 6.323145314365483 0.2064513634594627 0.9995954307317725 0.0068379222389900515 15.163971670532431 0.16623547487328458 45.37304290435602 0.0382307576440394 1.0000000000000041e-14 13.999999999999998 -6.11669395090602 EK(ub)IQPEILELIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKIQPEILELIK 12 1 H0YCM7;Q5JVZ5;Q96JJ3-3;Q96JJ3;Q5JW01;Q92556;Q92556-2;Q92556-3 H0YCM7;Q92556 ELMO2;ELMO1 Engulfment and cell motility protein 2;Engulfment and cell motility protein 1 1 30516700.0 10041100.0 18169600.0 2306000.0 True False 13163979.338150714 15458766.50454608 2067397.2407139488 1.0 1.1743232124153227 0.1570495659106966 23.650092331370537 -6.862761305354169 1.1718007540537205 1.0953558965734285 0.10514871309945784 0.9569038463734413 0.09221360221574933 0.14397882610795637 0.37412584638673496 0.061308142117512114 0.14357672991259757 1.3716354300745273e-07 6.862761305354169 -0.9902071834739706 down EK(ub)IQPEILELIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKIQPEILELIK 12 1 H0YCM7;Q5JVZ5;Q96JJ3-3;Q96JJ3;Q5JW01;Q92556;Q92556-2;Q92556-3 H0YCM7;Q92556 ELMO2;ELMO1 Engulfment and cell motility protein 2;Engulfment and cell motility protein 1 1 32396300.0 15242400.0 13501800.0 3652100.0 True False 14758538.355267946 18893139.150956824 2695505.4493484804 1.0 1.2801497476349388 0.1826404068249984 23.815046512166532 -6.838994637137537 1.2869525199772076 1.1490631350395413 0.14723186925671314 0.9227284393736193 0.12942761310743459 0.16997593194631083 0.5472776206441612 0.07886982126203068 0.18166521844386221 1.4487897437379045e-07 6.838994637137537 -1.001831265782828 down EK(ub)IQPEILELIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKIQPEILELIK 12 1 H0YCM7;Q5JVZ5;Q96JJ3-3;Q96JJ3;Q5JW01;Q92556;Q92556-2;Q92556-3 H0YCM7;Q92556 ELMO2;ELMO1 Engulfment and cell motility protein 2;Engulfment and cell motility protein 1 1 32854800.0 16539400.0 3743000.0 12572400.0 True False 25091478.992104862 3075032.405807517 10087459.629321314 1.0 0.12255285576330868 0.4020273030735006 24.580694175679568 -10.316144023145092 5.659404659587768 1.0000994644584347 0.2622900797255261 0.9028203019290688 0.1140949653427423 0.0001432072695575529 1.7304230870973854e-05 0.11048668193676955 0.036823991721542694 4.8289863395972536e-11 10.316144023145092 -0.7378093847329086 EK(ub)IQPEILELIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKIQPEILELIK 12 1 H0YCM7;Q5JVZ5;Q96JJ3-3;Q96JJ3;Q5JW01;Q92556;Q92556-2;Q92556-3 H0YCM7;Q92556 ELMO2;ELMO1 Engulfment and cell motility protein 2;Engulfment and cell motility protein 1 1 38052600.0 15242400.0 21174600.0 1635600.0 True False 12674730.952811897 21060528.226970986 1977596.3978400514 1.0 1.6616154067001079 0.15602669636165495 23.59545178760081 -6.787256067287302 1.5072184501858572 1.371105641478252 0.14119277861205462 0.7923127648373331 0.2807985781161938 0.23947713420991307 1.0747562205935088 0.14666354467356127 0.34408296225809243 1.6320893569713405e-07 6.787256067287302 -1.2299128628661975 EK(ub)IQPEILELIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKIQPEILELIK 12 1 H0YCM7;Q5JVZ5;Q96JJ3-3;Q96JJ3;Q5JW01;Q92556;Q92556-2;Q92556-3 H0YCM7;Q92556 ELMO2;ELMO1 Engulfment and cell motility protein 2;Engulfment and cell motility protein 1 1 28046400.0 16539400.0 4445600.0 7061400.0 True False 21410579.34031502 4198198.452003532 5776297.656082574 1.0 0.1960805630372897 0.26978707882070724 24.351820497772017 -10.160534978077022 5.153099979711689 1.0000362231016824 0.23293382092833761 0.9931228208819955 0.030090559066931102 1.252294667007582e-05 2.040083775349057e-06 0.02913642862080078 0.009711686178360181 6.909792756938066e-11 10.160534978077022 -0.7671024021733448 EK(ub)IQQDADSVITVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKIQQDADSVITVGR 15 1 Q9H3P7 Q9H3P7 ACBD3 Golgi resident protein GCP60 1 17420100.0 9673700.0 5542400.0 2204000.0 True False 12682314.380244073 4715495.52410599 1975951.2222608565 1.0 0.3718166403012034 0.1558036777056168 23.59631470939093 -11.19660425534678 0.20402026481856778 2.096106678350036 1.964684828011972e-11 0.9993596660806054 0.009060958848042467 3.4651982208507883 0.11677630262813422 1.868003832748898 0.1299690643528248 6.3591013195686434e-12 11.19660425534678 -2.096106678330389 EK(ub)IQQDADSVITVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKIQQDADSVITVGR 15 1 Q9H3P7 Q9H3P7 ACBD3 Golgi resident protein GCP60 1 23048200.0 11216000.0 8395600.0 3436600.0 True False 10859954.219328003 11748006.862475626 2536451.3642099043 1.0 1.0817731479537098 0.23356004205760417 23.372514685614615 -6.883239706212686 1.0615274466857176 1.0532309738763062 0.16957501643939576 0.976207658212435 0.05892858599280327 0.12480073144130735 0.25525246569315535 0.04262934863141861 0.10399534962073147 1.3084595273341999e-07 6.883239706212686 -0.8836559574369104 down EK(ub)IQQDADSVITVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKIQQDADSVITVGR 15 1 Q9H3P7 Q9H3P7 ACBD3 Golgi resident protein GCP60 1 41275000.0 19529000.0 10422000.0 11324000.0 True False 29626920.761140972 8562112.67254233 9085806.436514473 1.0 0.2889977241162538 0.306674004692095 24.820405353504942 -10.004501518279344 7.393523891367927 1.000000030633521 0.29783586450357186 0.9995249277559863 0.007216311326847188 3.642450373195009e-09 4.928759372616011e-10 0.006987163709830203 0.0023290544658271955 9.896884039446735e-11 10.004501518279344 -0.7021641661299491 EK(ub)IQQDADSVITVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKIQQDADSVITVGR 15 1 Q9H3P7 Q9H3P7 ACBD3 Golgi resident protein GCP60 1 17209300.0 9673700.0 5099000.0 2436600.0 True False 13250328.31191284 4873709.3198618665 1861125.263352204 1.0 0.3678180045908832 0.14045880370216493 23.659524770913823 -10.440779998750614 0.2282462335627365 1.7447233522818124 2.9531603197391068e-12 0.9992258619648205 0.010117892690503677 2.1073391111341038 0.11427512942928471 1.0192064101608074 0.11505784926904616 3.624265469173123e-11 10.440779998750614 -1.7447233522788592 EK(ub)IQQDADSVITVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKIQQDADSVITVGR 15 1 Q9H3P7 Q9H3P7 ACBD3 Golgi resident protein GCP60 1 23318900.0 11216000.0 9509800.0 2593100.0 True False 9326600.953047954 9458568.819852484 3135305.2208602554 1.0 1.0141496207963527 0.33616804628438945 23.15291996104889 -6.902137522601648 0.9476888596306096 1.0265587056581793 0.26183930360101104 0.9875991486352155 0.03522525025546379 0.10984792450545731 0.16869295773612422 0.027762264608209006 0.07303624488726593 1.2527444212200398e-07 6.902137522601648 -0.7647194020571683 down EK(ub)IQQDADSVITVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKIQQDADSVITVGR 15 1 Q9H3P7 Q9H3P7 ACBD3 Golgi resident protein GCP60 1 40807400.0 19529000.0 12075000.0 9203400.0 True False 25280675.474141225 11403015.63522192 7528475.6348585775 1.0 0.45105660435717754 0.2977956677842413 24.59153167559739 -13.999999999999988 0.1789900488551806 3.8394818416750005 0.17477470397402453 0.9994993906982701 0.006745017952896421 12.191838144133428 0.13410730768658086 12.03680295059677 0.11541992001115207 1.0000000000000286e-14 13.999999999999988 -3.664707137700976 EK(ub)KEDLEFQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKKEDLEFQAK 11 2 Q01831;Q01831-2 Q01831 XPC DNA repair protein complementing XP-C cells 1 5288400.0 1283400.0 2575400.0 1429600.0 True False 1682549.8284632787 2191160.358830575 1281678.7056915266 1.0 1.3022855678704177 0.7617478448540931 20.682217799991797 -6.7549309096100085 1.631390026898772 1.1766870340342566 0.7602427989209716 0.6699817485691485 0.12706699545801306 0.29152741612393496 1.5278974037148048 0.06148923137546598 0.14852684476315314 1.75820329812373e-07 6.7549309096100085 -0.416444235113285 EK(ub)KEDLEFQAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKKEDLEFQAK 11 2 Q01831;Q01831-2 Q01831 XPC DNA repair protein complementing XP-C cells 1 21650500.0 3603000.0 6875500.0 11172000.0 True False 5466014.414582974 5648513.306473316 8963849.303138442 1.0 1.0333879272991755 1.6399241976427048 22.382057833762673 -6.918254683843869 0.8375533807654362 0.9857577376588476 1.7339173131742271 0.9936827517504794 0.023376157379899835 0.09920910044832625 0.11100970032604855 0.019957160183971447 0.05882056306527921 1.2071057430070757e-07 6.918254683843869 0.7481595755153796 EK(ub)KEDLEFQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKKEDLEFQAK 11 2 Q01831;Q01831-2 Q01831 XPC DNA repair protein complementing XP-C cells 1 3754400.0 1283400.0 1128700.0 1342300.0 True False 1757907.6625809064 1078830.3018882312 1025276.3855362675 1.0 0.6137013478309352 0.583236769120733 20.74542786151469 -13.999999999997902 0.36010781249543844 6.057817092414333 0.5795742291374067 0.9997734845817404 0.002854935043485694 21.70860425663099 0.19394870606477577 84.38657426581341 0.008787938259402075 1.0000000000048305e-14 13.999999999997902 -5.478242863276926 EK(ub)KEDLEFQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKKEDLEFQAK 11 2 Q01831;Q01831-2 Q01831 XPC DNA repair protein complementing XP-C cells 1 4101800.0 1754600.0 1289800.0 1057400.0 True False 1459027.641959515 1282851.5913947439 1278497.451134796 1.0 0.8792510535796555 0.8762667782069833 20.47657578536966 EK(ub)KEDLEFQAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKKEDLEFQAK 11 2 Q01831;Q01831-2 Q01831 XPC DNA repair protein complementing XP-C cells 1 28671900.0 3603000.0 4261900.0 20807000.0 True False 4664154.525747904 4024721.5184888057 17020339.497848887 1.0 0.8629048407960789 3.6491800183484813 22.153184155855122 -6.895330599094116 0.9903251788280582 0.8688540788192137 3.915418959297742 0.9840962510549993 0.16171989662968259 0.11492413407496437 0.19744048214086324 0.12347220044788956 0.31434858606372623 1.2725340179121102e-07 6.895330599094116 3.0465648804785284 up EK(ub)KEVVEEAENGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKKEVVEEAENGR 13 2 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 1 11297000.0 4222700.0 4466100.0 2608200.0 True False 5536000.592684964 3799775.2887214497 2338328.483621038 1.0 0.6863755205774926 0.4223858802888869 22.400412666753944 -7.298613904018042 0.19648945831793707 1.187220623657692 1.0674718583465878e-11 0.999980392418617 0.0010454454790356752 0.10679058557818749 0.011992146125497693 0.019395208881373974 0.046756478865154716 5.027893801281055e-08 7.298613904018042 -1.1872206236470173 down EK(ub)KEVVEEAENGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKKEVVEEAENGR 13 2 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 1 14904400.0 6047100.0 4638500.0 4218800.0 True False 5855138.120515184 6490677.239457953 3113769.7187129008 1.0 1.1085438303694275 0.5318012409994054 22.481271773087723 -6.858023881498021 1.1955913373404918 1.0586153386044141 0.5048974261153933 0.9511961341118993 0.05528413753468552 0.14885958181630327 0.40544879663587186 0.03609097674816224 0.08407339911739999 1.3866795744007444e-07 6.858023881498021 -0.5537179124890208 EK(ub)KEVVEEAENGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKKEVVEEAENGR 13 2 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 1 24118500.0 6196000.0 11223000.0 6699500.0 True False 9399784.988275366 9220167.964300774 5375340.888504836 1.0 0.9808913688771995 0.5718578558136872 23.164196326125452 -6.916651498704591 0.8491850848911644 1.0101594747109641 0.5107220777979908 0.9931991957417078 0.016285442993718445 0.10018242942338756 0.11611766337506656 0.013788220582479069 0.04006826380905713 1.211569972605053e-07 6.916651498704591 -0.4994373969129733 EK(ub)KEVVEEAENGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKKEVVEEAENGR 13 2 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 1 24833700.0 6196000.0 11581000.0 7056700.0 True False 8020844.141419384 10936507.169482833 5772453.007856498 1.0 1.3635107448363268 0.7196814831555863 22.935322648217902 -6.753475925424475 1.6366249225849059 1.2128411538190085 0.718024078166976 0.6639871819971301 0.15278410937347997 0.29399334888294665 1.5502954256773578 0.07370825178124789 0.17832063397271125 1.764103552656709e-07 6.753475925424475 -0.4948170756520325 EK(ub)KPGDLSDELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKKPGDLSDELR 12 2 Q13435;E9PPJ0;H0YEX5 Q13435 SF3B2 Splicing factor 3B subunit 2 1 28541300.0 9953900.0 11926000.0 6661400.0 True False 13049659.293704733 10146687.287183888 5972142.22866084 1.0 0.7775442299921759 0.4576473679693578 23.63750880497611 -6.9659489617009145 0.3413738669788918 1.0341498199438048 0.1903885481707756 0.9999313909643205 0.0018438203806446175 0.07764039082310496 0.013732614876311828 0.004497074123422115 0.027660782395347888 1.0815610489128217e-07 6.9659489617009145 -0.8437612717730292 down EK(ub)KPGDLSDELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKKPGDLSDELR 12 2 Q13435;E9PPJ0;H0YEX5 Q13435 SF3B2 Splicing factor 3B subunit 2 1 33395700.0 14212000.0 9506100.0 9677600.0 True False 21560643.036373388 7809662.183501701 7764818.118157233 1.0 0.3622184259683994 0.3601385220773692 24.361896870667106 EK(ub)KPGDLSDELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKKPGDLSDELR 12 2 Q13435;E9PPJ0;H0YEX5 Q13435 SF3B2 Splicing factor 3B subunit 2 1 25984000.0 9953900.0 7868500.0 8161600.0 True False 13634125.824033124 7520843.652350079 6233998.173428289 1.0 0.5516190586339573 0.4572349011507218 23.700718866499003 -13.999999999999998 0.2190188069100236 3.6941430150145482 0.4062714915208181 0.9994969282882461 0.005310612233749898 12.973068722248216 0.14826495576037807 15.108794294824566 0.0525744388243 1.0000000000000041e-14 13.999999999999998 -3.28787152349373 EK(ub)KPGDLSDELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKKPGDLSDELR 12 2 Q13435;E9PPJ0;H0YEX5 Q13435 SF3B2 Splicing factor 3B subunit 2 1 32631400.0 10731000.0 17316000.0 4584400.0 True False 8923301.963904927 17222715.271043107 5542976.844129325 1.0 1.9300832069462182 0.6211800145899873 23.08914623075465 -6.715835368072799 1.7740624241640712 1.568337461308437 0.6236452990457159 0.4929390212649386 0.3915938853641801 0.3634536608216042 2.2331510375895594 0.17541410504824761 0.4425663612843361 1.923820870833295e-07 6.715835368072799 -0.9446921622627212 EK(ub)KPGDLSDELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKKPGDLSDELR 12 2 Q13435;E9PPJ0;H0YEX5 Q13435 SF3B2 Splicing factor 3B subunit 2 1 33556500.0 14212000.0 9130500.0 10214000.0 True False 18397714.160402242 8622379.648645438 8355156.804490236 1.0 0.4686658121476609 0.4541410270670039 24.133023192759556 EK(ub)LCYVALDFEQEMATAASSSSLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKLCYVALDFEQEMATAASSSSLEK 25 1 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L4N8;Q6S8J3 P60709;P63261;Q6S8J3 ACTB;ACTG1;POTEE Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member E 1 111754800.0 6777800.0 17722000.0 87255000.0 True False 10282418.123552728 14559370.63738202 70009011.00477488 1.0 1.4159481225561696 6.80861351518214 23.293676248258464 -6.922308812288928 0.8074210252086659 0.8906241690202302 7.7261433825224435 0.9947985644565961 0.19080485030494385 0.09683219446273256 0.09871477390710402 0.16644080726438776 0.5101240976498725 1.1958898715925408e-07 6.922308812288928 6.835519213502213 up EK(ub)LCYVALDFEQEMATAASSSSLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKLCYVALDFEQEMATAASSSSLEK 25 1 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L4N8;Q6S8J3 P60709;P63261;Q6S8J3 ACTB;ACTG1;POTEE Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member E 1 101135800.0 6777800.0 14557000.0 79801000.0 True False 8773995.710411917 13746890.15336859 65278036.82740601 1.0 1.566776484407833 7.439944009767628 23.064802570350913 -6.925620732144822 0.7818956533991462 0.8947224610267274 8.521414693362766 0.9956054905702001 0.19300237858641248 0.09497612307331692 0.08929110944117134 0.17145244354277178 0.5447744913738971 1.1868047281691271e-07 6.925620732144822 7.626692232336039 up EK(ub)LDTLVEFPIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKLDTLVEFPIR 12 1 P51784;G5E9A6 P51784 USP11 Ubiquitin carboxyl-terminal hydrolase 11;Ubiquitin carboxyl-terminal hydrolase 1 27632600.0 8392900.0 10936000.0 8303700.0 True False 8126471.98354118 15302801.830486594 6128711.864339686 1.0 1.8830806113009284 0.7541663684748282 22.954197727708063 -6.698048486470358 1.8380085145986276 1.5494147195451027 0.7576675837895853 0.40821228884541305 0.37289574228241157 0.39961085073720776 2.6232453558916697 0.1619445829147338 0.41745718825644174 2.004248252133258e-07 6.698048486470358 -0.7917471357555174 EK(ub)LDTLVEFPIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKLDTLVEFPIR 12 1 P51784;G5E9A6 P51784 USP11 Ubiquitin carboxyl-terminal hydrolase 11;Ubiquitin carboxyl-terminal hydrolase 1 37935000.0 12893000.0 14168000.0 10874000.0 True False 19559623.604556847 11639609.70491076 8724749.133756489 1.0 0.5950835220673191 0.4460591527806223 24.221375272279595 -13.999999999999998 0.138923538334061 2.9324557766191814 0.2592198430748026 0.9996072599303256 0.004638329073174025 11.93304878021498 0.11669806682811347 6.255170911149873 0.16691395292266623 1.0000000000000041e-14 13.999999999999998 -2.6732359335443787 EK(ub)LDTLVEFPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKLDTLVEFPIR 12 1 P51784;G5E9A6 P51784 USP11 Ubiquitin carboxyl-terminal hydrolase 11;Ubiquitin carboxyl-terminal hydrolase 1 22929200.0 8392900.0 7987400.0 6548900.0 True False 6979068.218512488 7944370.290825225 7918244.711307607 1.0 1.1383138897757445 1.1345704703536046 22.73460300314234 -10.128199455393442 4.829562521546506 0.9999915951122479 1.136442180065526 0.9994357623946409 0.0015282445825129953 1066760.4274298267 0.018241976316055585 99.70712482284354 0.0005231587690742638 7.443900245821454e-11 10.128199455393442 0.1364505849532781 EK(ub)LDTLVEFPIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKLDTLVEFPIR 12 1 P51784;G5E9A6 P51784 USP11 Ubiquitin carboxyl-terminal hydrolase 11;Ubiquitin carboxyl-terminal hydrolase 1 36772000.0 12893000.0 10492000.0 13387000.0 True False 16690242.659025189 9908110.976790752 10950703.362219596 1.0 0.5936469097070304 0.6561140892878536 23.992501594372044 -10.543275537533457 6.303779380004082 1.000495540771447 0.6248804994974658 0.9796255496306253 0.02550211927397023 0.00017783173063653607 1.2884372822407548e-05 0.024723656407460517 0.008230773603423492 2.862361372484245e-11 10.543275537533457 -0.37561504127398126 EK(ub)LEATINELV ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKLEATINELV 11 1 P10599;P10599-2 P10599 TXN Thioredoxin 1 43082000.0 14523000.0 16140000.0 12419000.0 True False 18800309.791128747 15241794.811799726 10158869.429700825 1.0 0.8107204073303 0.5403564910666773 24.164253099010345 -6.966057784539839 0.3394139401362719 1.0295246484914036 0.3125753665859424 0.9999333125720103 0.0015403000724415808 0.07760387712711933 0.013604677602206263 0.003823435177163948 0.02341121421345571 1.0812900719516597e-07 6.966057784539839 -0.7169492819054611 EK(ub)LGCQDAFPEVYDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKLGCQDAFPEVYDK 15 1 A0A0A0MTI1;Q15392;Q15392-2 A0A0A0MTI1 DHCR24 Delta(24)-sterol reductase 1 27367700.0 3170000.0 4111700.0 20086000.0 True False 4155900.698323672 3498250.3872810695 18007693.39851705 1.0 0.8417550469124845 4.3330422706636496 21.98672975201973 -6.896284631880836 0.98447159908541 0.8396806445177906 4.673055967828253 0.9846250122700786 0.19960946074652838 0.11419152721407559 0.19325053403411402 0.15307107438222345 0.39133040033718836 1.26974165757482e-07 6.896284631880836 3.833375323310462 up EK(ub)LGCQDAFPEVYDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKLGCQDAFPEVYDK 15 1 A0A0A0MTI1;Q15392;Q15392-2 A0A0A0MTI1 DHCR24 Delta(24)-sterol reductase 1 206570000.0 0.0 53820000.0 152750000.0 True False 0.0 44215400.502420664 122558895.54729669 0.0 EK(ub)LGCQDAFPEVYDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKLGCQDAFPEVYDK 15 1 A0A0A0MTI1;Q15392;Q15392-2 A0A0A0MTI1 DHCR24 Delta(24)-sterol reductase 1 31199900.0 3170000.0 3672900.0 24357000.0 True False 4342034.666028894 3510619.1333439182 18604378.248161238 1.0 0.8085193701492565 4.2847143514808215 22.049939813542622 -6.893869494022406 0.9991919925768719 0.8301750896984567 4.607410134118743 0.983262254343101 0.20641404666761207 0.11606042231330489 0.20394863175723132 0.15654661201932032 0.3961291281458408 1.276822437738733e-07 6.893869494022406 3.777235044420286 up EK(ub)LGCQDAFPEVYDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKLGCQDAFPEVYDK 15 1 A0A0A0MTI1;Q15392;Q15392-2 A0A0A0MTI1 DHCR24 Delta(24)-sterol reductase 1 128150000.0 0.0 46486000.0 81664000.0 True False 0.0 43899013.23552184 66801989.94340039 0.0 EK(ub)LLSAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKLLSAER 8 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 2988710.0 748410.0 1138800.0 1101500.0 True False 724652.1342089222 1593528.778763548 812984.1057083192 1.0 2.1990258546649404 1.1218956894342498 19.466929076886895 -6.620505505653443 2.1152123528682263 1.7953135540133327 1.126041735467425 0.08440553922188909 0.5155581643259036 0.5840299608312746 4.966164128172125 0.20024286112285936 0.5715205136553807 2.396042374359471e-07 6.620505505653443 -0.6692718185459077 EK(ub)LLSAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKLLSAER 8 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 2856160.0 528760.0 1267600.0 1059800.0 True False 724256.8612017148 1211593.240607355 809497.0672661361 1.0 1.6728778220989622 1.117693335929172 19.466141921277746 -10.192303159311885 3.839142014886876 0.9996887303074267 1.3952855791922882 0.40330767091375164 0.22665311799298377 160470619.80470014 269893686.3133796 601091.5257741656 0.08294655195589326 6.422392456298074e-11 10.192303159311885 0.3955968488848616 EK(ub)LLSAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKLLSAER 8 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 3378110.0 748410.0 1848500.0 781200.0 True False 622336.075184613 1838541.7636014787 944545.3081393068 1.0 2.9542586986558415 1.517741531951385 19.24733435232117 -6.567133482082285 2.3177649192543597 2.3409330828363473 1.5205032382490082 0.0 0.8517445307936383 0.7389012929322553 7.447615988330326 0.31112193400662425 0.9557659489309314 2.709358772048711e-07 6.567133482082285 -0.820429844587339 EK(ub)LNEEHFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKLNEEHFR 9 1 Q99707;Q99707-2;A0A494C1A2;A0A494C064 Q99707 MTR Methionine synthase 1 5837900.0 2601700.0 2493000.0 743200.0 True False 3410853.8948986353 2121054.117637886 666300.793277799 1.0 0.6218542872241439 0.19534721034938976 21.701701527260056 -7.528729648936102 0.3886776823799863 1.0430328275642236 1.3703280822706595e-21 0.9989722308575211 0.010537605254606525 0.12049667352715966 0.048071879097606074 0.020649256768135043 0.06783954928370829 2.9598544212897863e-08 7.528729648936102 -1.0430328275642236 down EK(ub)LNEEHFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKLNEEHFR 9 1 Q99707;Q99707-2;A0A494C1A2;A0A494C064 Q99707 MTR Methionine synthase 1 7245800.0 3362200.0 2493100.0 1390500.0 True False 3255468.8013752354 3488607.8313447502 1026286.335894162 1.0 1.071614579710003 0.31524993741626983 21.634433881906833 -6.8836947950357965 1.0589377394979185 1.0469924567645559 0.2576901963651087 0.9765472201453206 0.052211028876775305 0.12440933167239693 0.2529141399568025 0.03784446874806878 0.09244345188536748 1.3070891359251086e-07 6.8836947950357965 -0.7893022603994472 down EK(ub)LNEEHFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKLNEEHFR 9 1 Q99707;Q99707-2;A0A494C1A2;A0A494C064 Q99707 MTR Methionine synthase 1 16176200.0 2127000.0 2417200.0 11632000.0 True False 3226814.5045290026 1985831.7743301995 9332930.101513285 1.0 0.6154155349007453 2.8923044967146487 21.621679215296556 -6.8634355118024555 1.1681598827410562 0.7890908993635047 3.0100719827989098 0.9576865911643513 0.20470495832134145 0.14330995696504634 0.3696563969896984 0.13646600478137658 0.31990885263007796 1.3695077308972963e-07 6.8634355118024555 2.220981083435405 up EK(ub)LNEEHFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKLNEEHFR 9 1 Q99707;Q99707-2;A0A494C1A2;A0A494C064 Q99707 MTR Methionine synthase 1 5250210.0 2601700.0 1910900.0 737610.0 True False 3563618.7982988474 1826470.1194987304 563401.7095547979 1.0 0.5125324067688234 0.15809819777125067 21.764911588782947 -8.129203145177264 0.33779825811528563 1.1058365239851369 4.372182681096936e-26 0.9985232988674629 0.013262698665226407 0.09231822080243086 0.07573220220935194 0.06516698875581328 0.08872430025433108 7.426716652385901e-09 8.129203145177264 -1.1058365239851369 down EK(ub)LNEEHFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKLNEEHFR 9 1 Q99707;Q99707-2;A0A494C1A2;A0A494C064 Q99707 MTR Methionine synthase 1 7445200.0 3362200.0 2976500.0 1106500.0 True False 2795818.2707148585 2960465.0037110094 1337864.0341220447 1.0 1.058890355900726 0.47852324599766216 21.41483915734111 -6.881902472398548 1.0691646600165612 1.0375013647049003 0.4358679441447865 0.9751865298260199 0.04108473858121524 0.12595673023268644 0.2622334578714175 0.029549368030452716 0.07181415412508257 1.3124946070679048e-07 6.881902472398548 -0.6016334205601137 down EK(ub)LNEEHFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKLNEEHFR 9 1 Q99707;Q99707-2;A0A494C1A2;A0A494C064 Q99707 MTR Methionine synthase 1 18180400.0 2127000.0 2071400.0 13982000.0 True False 2753443.42943819 1956124.7690930609 11437419.467435127 1.0 0.7104285303919197 4.153860342708696 21.392805537389005 -6.886474955622043 1.04303657400639 0.7990439395657838 4.430326704288855 0.9785434539909391 0.228434024896853 0.12204873184681626 0.2389416875221347 0.16760038046098244 0.41285495964571944 1.2987484563519576e-07 6.886474955622043 3.631282764723071 up EK(ub)NHGSSPEQVVRPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKNHGSSPEQVVRPK 15 2 O43164-2;O43164 O43164-2 PJA2 E3 ubiquitin-protein ligase Praja-2 1 4494840.0 2030600.0 1766100.0 698140.0 True False 2628651.729110102 1667814.9824733282 571085.6835213252 1.0 0.6344754476234653 0.21725422093654806 21.32589158082404 -7.468929735353631 0.37348215634060294 1.0465680485960487 3.0864176605884845e-22 0.9992783009187921 0.00859089851597061 0.11851964441867519 0.04086209809863544 0.018309524912963872 0.06387983794711076 3.3968022511969236e-08 7.468929735353631 -1.0465680485960487 down EK(ub)PSYDTETDPSEGLMNVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKPSYDTETDPSEGLMNVLK 20 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 27096400.0 7583600.0 13904000.0 5608800.0 True False 9942173.03968686 11829577.397367496 5028455.179408669 1.0 1.1898382124457654 0.5057702334626681 23.24512978237392 -6.832669134193132 1.3159293426874172 1.1012638569172586 0.4863364236161307 0.9111128032010226 0.08596504383595785 0.17753822109767306 0.6003160891608292 0.05127693851921883 0.11800332608055866 1.4700458006421208e-07 6.832669134193132 -0.6149274333011279 EK(ub)PSYDTETDPSEGLMNVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKPSYDTETDPSEGLMNVLK 20 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 41261400.0 14695000.0 16705000.0 9861400.0 True False 14228515.268636331 23375393.61542418 7278403.504341367 1.0 1.642855433198301 0.5115364018609183 23.762281790142687 -6.752575695950388 1.6404826634099063 1.3768329557109111 0.5088603631808409 0.6599249029550437 0.2701722770100458 0.2955664853484477 1.5657806423014062 0.13006141792830964 0.31488371618290323 1.767764076025009e-07 6.752575695950388 -0.8679725925300702 EK(ub)PSYDTETDPSEGLMNVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKPSYDTETDPSEGLMNVLK 20 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 39310700.0 7583600.0 24452000.0 7275100.0 True False 10387461.85908412 23371629.788049076 5556871.215387689 1.0 2.2499846550685474 0.5349594819958884 23.30833984389681 -6.711300413792027 1.7908727952801624 1.767444908828871 0.538882431905361 0.47117965224312663 0.5266298406901209 0.37244622025673346 2.3293730076228734 0.2339588033033854 0.5933624952786538 1.9440148862715618e-07 6.711300413792027 -1.2285624769235102 EK(ub)PSYDTETDPSEGLMNVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 EKPSYDTETDPSEGLMNVLK 20 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 52634600.0 17795200.0 29028200.0 5811200.0 True False 14797497.261026999 28871819.324953414 7026295.05204703 1.0 1.9511285466492194 0.47482996131734917 23.8188498539556 -6.732722379124117 1.713134899112152 1.570627995400245 0.4752312692982019 0.5719467892092873 0.3997525353548876 0.33114202868580267 1.9051064327099172 0.18481917642436246 0.45723911568214365 1.850451133891503e-07 6.732722379124117 -1.095396726102043 EK(ub)PSYDTETDPSEGLMNVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKPSYDTETDPSEGLMNVLK 20 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 63495000.0 17114000.0 25328000.0 21053000.0 True False 22154410.367374334 23918474.534898616 17221570.02202204 1.0 1.0796258685413775 0.7773427383733653 24.40109059467408 -6.836674108930885 1.297627305068077 1.042395695694257 0.768030044721035 0.9186009910823315 0.036498694182031215 0.1727215675601498 0.5663610426202543 0.022065974914807395 0.05080284175582935 1.4565516551908644e-07 6.836674108930885 -0.2743656509732221 EK(ub)PVDLQNFGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKPVDLQNFGLR 12 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 12246900.0 3206800.0 5870900.0 3169200.0 True False 4204145.854695381 4994984.604588956 2841281.58511303 1.0 1.1881092562500728 0.6758284996082516 22.003381291001894 -6.807313056890028 1.4257709080759324 1.1028486476858699 0.6674045714959735 0.8527002339123062 0.08120456972798895 0.21048917734146566 0.843813361462032 0.04479011455875696 0.1037418694108541 1.5584287198834026e-07 6.807313056890028 -0.43544407618989633 EK(ub)PVDLQNFGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKPVDLQNFGLR 12 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 17959600.0 8449300.0 5171500.0 4338800.0 True False 8181081.596412984 7236506.9190162355 3202338.118790063 1.0 0.8845415894872752 0.39143212068611277 22.96386015951172 -6.94337262587943 0.6274102492229409 1.0053800070620127 0.244135842664424 0.9985730396057518 0.009969280924163807 0.08626133742720962 0.04785346309100007 0.009973019495695767 0.04185156599843748 1.1392718696443155e-07 6.94337262587943 -0.7612441643975887 down EK(ub)PVDLQNFGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKPVDLQNFGLR 12 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 15989900.0 8449300.0 7540600.0 0.0 True False 7025967.317456135 7499977.291108081 0.0 1.0 1.0674654395949523 0.0 22.744265434945998 -6.978269683189548 1.156044276798195 1.045774123756632 6.150680712945948e-22 0.9793806284619955 0.07008616472982301 0.09756857795602002 0.2570300351379769 0.05083707539276567 0.09455123596193458 1.0513088414219624e-07 6.978269683189548 -1.045774123756632 down EK(ub)PYFPIPEEYTFIQNVPLEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKPYFPIPEEYTFIQNVPLEDR 22 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 59779000.0 23564000.0 21058000.0 15157000.0 True False 22815973.718281455 29466569.216019273 11186926.999746712 1.0 1.2914885676086216 0.4903111801353063 24.443540889266615 -6.808267531317187 1.421842276882322 1.1591889236866821 0.4768498609129784 0.8552360108379691 0.12597574668577394 0.20917984862873223 0.8337971023834418 0.06967379380971195 0.1612971283896594 1.5550074307419898e-07 6.808267531317187 -0.6823390627737038 down EK(ub)PYFPIPEEYTFIQNVPLEDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKPYFPIPEEYTFIQNVPLEDR 22 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 195904000.0 37955000.0 67952000.0 89997000.0 True False 57580509.88218072 55825434.68860067 72209053.50291368 1.0 0.9695196309103336 1.2540537353813885 25.77907722840355 -6.880388713429907 1.0775764031078223 0.9810076867383078 1.2743736560463774 0.9739998702989243 0.020567641682353262 0.12728873120865317 0.2701814412187414 0.014697384098208763 0.03557895950301841 1.3170773663410506e-07 6.880388713429907 0.2933659693080696 EK(ub)PYFPIPEEYTFIQNVPLEDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKPYFPIPEEYTFIQNVPLEDR 22 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 55064700.0 23564000.0 22431000.0 9069700.0 True False 19594510.0621988 22310159.750795126 10966132.336445292 1.0 1.138592375107928 0.5596533060349828 24.22394616470089 -6.843533470767569 1.2660148863470404 1.073725787089101 0.5392565350375951 0.930337485197093 0.06514497283105496 0.1647157307908472 0.51131898843744 0.040324792331642226 0.09300061804045127 1.433727215458562e-07 6.843533470767569 -0.534469252051506 EK(ub)PYFPIPEEYTFIQNVPLEDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKPYFPIPEEYTFIQNVPLEDR 22 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 179149000.0 37955000.0 60171000.0 81023000.0 True False 49133495.70490202 56822430.95544003 66277645.36618483 1.0 1.1564907023249087 1.3489299797484662 25.550203550496 -6.968348521678855 0.294980987640507 0.9645699422652827 1.5468379508767567 0.9999664792181586 0.0008261826126748814 0.07684233204865173 0.010938301085427456 0.003274850028742339 0.0173531148257694 1.0756016959438697e-07 6.968348521678855 0.582268008611474 EK(ub)QAALEEEQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKQAALEEEQAR 12 1 H0YEF7;H0YEH1;Q13492-3;Q13492-2;Q13492-4;Q13492;Q13492-5;H0YCY1 H0YEF7;Q13492-3 PICALM Phosphatidylinositol-binding clathrin assembly protein 1 21821720.0 6326700.0 8494400.0 7000620.0 True False 8294364.967849951 7227068.6309118625 6276262.997088847 1.0 0.8713227183666176 0.7566899963308182 22.983700099293237 -6.9724912652711994 0.1894507903761761 1.0782514723670715 0.5466314231402198 0.9999958528463878 0.00020231294465808609 0.07550232408181942 0.0060399525402892815 0.004066055771497542 0.012515310642150043 1.0653902910677845e-07 6.9724912652711994 -0.5316200492268517 EK(ub)QAALEEEQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKQAALEEEQAR 12 1 H0YEF7;H0YEH1;Q13492-3;Q13492-2;Q13492-4;Q13492;Q13492-5;H0YCY1 H0YEF7;Q13492-3 PICALM Phosphatidylinositol-binding clathrin assembly protein 1 27112720.0 11403700.0 7347000.0 8362020.0 True False 11041695.785569778 10280695.414098848 6171756.106777191 1.0 0.9310793933966675 0.5589500224089641 23.396458422700377 -6.938107218619179 0.6769500213390867 1.0043454893889951 0.4639523257008097 0.9979052174143638 0.008866440059095437 0.08864108884911644 0.05862366760746683 0.008511670457558887 0.032304700009568595 1.1531685284359164e-07 6.938107218619179 -0.5403931636881855 EK(ub)QAALEEEQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKQAALEEEQAR 12 1 H0YEF7;H0YEH1;Q13492-3;Q13492-2;Q13492-4;Q13492;Q13492-5;H0YCY1 H0YEF7;Q13492-3 PICALM Phosphatidylinositol-binding clathrin assembly protein 1 44953000.0 16702000.0 18531200.0 9719800.0 True False 25338155.07975714 15224162.575073566 7798677.269660321 1.0 0.6008394268308933 0.30778394263956294 24.594808147088717 -7.970339375832128 0.22898144525205974 1.201812005187716 2.2708924625541836e-14 0.9997387456691101 0.004585550729837194 0.10562991747055592 0.03988499495746083 0.06880063773933251 0.09722294952334337 1.0706823024129323e-08 7.970339375832128 -1.2018120051876933 down EK(ub)QAALEEEQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKQAALEEEQAR 12 1 H0YEF7;H0YEH1;Q13492-3;Q13492-2;Q13492-4;Q13492;Q13492-5;H0YCY1 H0YEF7;Q13492-3 PICALM Phosphatidylinositol-binding clathrin assembly protein 1 20791800.0 6326700.0 9250400.0 5214700.0 True False 8665851.96263879 8841686.741017878 3983095.260117682 1.0 1.020290535672334 0.4596311219358532 23.04691016081613 -6.898500047763961 0.9706726424482898 1.024279172612179 0.402534854715329 0.9858060419618826 0.030933930504953393 0.1125188159271299 0.1836992477307138 0.023966771517125278 0.06190310565820215 1.2632809648709693e-07 6.898500047763961 -0.6217443178968499 down EK(ub)QAALEEEQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKQAALEEEQAR 12 1 H0YEF7;H0YEH1;Q13492-3;Q13492-2;Q13492-4;Q13492;Q13492-5;H0YCY1 H0YEF7;Q13492-3 PICALM Phosphatidylinositol-binding clathrin assembly protein 1 18172040.0 11403700.0 1671600.0 5096740.0 True False 9482681.819567837 1662594.7590133776 6162444.769336819 1.0 0.1753295945860544 0.6498630752980031 23.176863698134653 -10.410119038203993 5.361693346535235 1.0004038088415672 0.4125963350079361 0.6713819877101562 0.19372748226854827 0.000935746723608275 0.00010294872068229444 0.18770006083205698 0.06252527604406088 3.8893852404699997e-11 10.410119038203993 -0.5878074738336312 EK(ub)QAALEEEQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKQAALEEEQAR 12 1 H0YEF7;H0YEH1;Q13492-3;Q13492-2;Q13492-4;Q13492;Q13492-5;H0YCY1 H0YEF7;Q13492-3 PICALM Phosphatidylinositol-binding clathrin assembly protein 1 38389700.0 16702000.0 16530000.0 5157700.0 True False 21621068.24564019 15610090.968962185 4219051.522471046 1.0 0.7219851855428052 0.1951361271579078 24.365934469181166 -7.186598681118948 0.4886693168807847 1.0120705843310573 2.2853070423029683e-11 0.9992547763360925 0.009111724051121041 0.0860195502230898 0.03500236833332816 0.010555896764750482 0.04689454077694437 6.507307339142993e-08 7.186598681118948 -1.0120705843082043 down EK(ub)QAEEMASDDLSLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKQAEEMASDDLSLIR 16 1 E9PMH5;Q13490-2;Q13490;A0A087X2B2;E9PIW1 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 12630500.0 4034700.0 4040600.0 4555200.0 True False 5289530.772090377 3437758.2301354413 4083871.600563825 1.0 0.6499174271325524 0.7720668952550425 22.334708317598597 -10.373087842201047 5.064738596753025 1.0001930916172315 0.710992161193765 0.8818533158924907 0.04986731154218969 0.00010879923419643382 1.3467075928652485e-05 0.04831582897712483 0.016094605593570257 4.2355728693341535e-11 10.373087842201047 -0.2892009304234665 EK(ub)QAEEMASDDLSLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKQAEEMASDDLSLIR 16 1 E9PMH5;Q13490-2;Q13490;A0A087X2B2;E9PIW1 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 13019300.0 5754700.0 4229300.0 3035300.0 True False 4785288.0264359 4206515.921449678 3669967.1963584665 1.0 0.8790517724766312 0.7669271266607273 22.190174332448215 -6.972035245835217 0.20379715991855407 1.063555151323265 0.5793151619232176 0.999994203653238 0.00022906518916153895 0.07564766074993677 0.006611381620646833 0.0035290668528309907 0.011791513185238496 1.0665095634974797e-07 6.972035245835217 -0.4842399894000474 EK(ub)QLAAENR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKQLAAENR 9 1 P35579;P35579-2 P35579 MYH9 Myosin-9 1 14022900.0 6830700.0 5282400.0 1909800.0 True False 8955113.848592887 4494286.5106339315 1712192.2160951842 1.0 0.5018681600949291 0.19119714668554663 23.0942803429934 -8.437372944409523 0.2795718831118262 1.1911372882913893 1.2430506230189133e-18 0.9990754038358496 0.010129709701112925 0.14259057317974022 0.07272151933508399 0.11597741173675309 0.10164771660717137 3.652809768785124e-09 8.437372944409523 -1.1911372882913893 down EK(ub)QLAAENR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKQLAAENR 9 1 P35579;P35579-2 P35579 MYH9 Myosin-9 1 9000000.0 3421400.0 4447900.0 1130700.0 True False 3312789.529779671 6223969.665492077 834535.7497270966 1.0 1.8787700243383783 0.2519133021356175 21.659615117449235 -6.759969824783719 1.6124182720454747 1.5104385490621066 0.24593228753074584 0.6909629091411353 0.3696115594122373 0.28293834179522204 1.4497819684344175 0.18085842179686681 0.4346729335700943 1.737921577089103e-07 6.759969824783719 -1.2645062615313607 EK(ub)QLAAENR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKQLAAENR 9 1 P35579;P35579-2 P35579 MYH9 Myosin-9 1 11735600.0 6830700.0 3582500.0 1322400.0 True False 9356194.382726656 3424213.304256741 1010076.355682902 1.0 0.3659835574363975 0.10795803447047854 23.15749040451629 -9.408467574265826 0.2885339429282028 1.346658618172715 2.0090005660487574e-16 0.9987339594008013 0.013336024004053003 0.8105290970494031 0.11466263705699915 0.3640184770615443 0.09287756491949019 3.904203313774161e-10 9.408467574265826 -1.3466586181727147 EK(ub)QLAAENR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKQLAAENR 9 1 P35579;P35579-2 P35579 MYH9 Myosin-9 1 7857200.0 3421400.0 3359300.0 1076500.0 True False 2845045.6937195286 3341202.784131157 1301591.1728263746 1.0 1.17439336440427 0.45749394313759256 21.44002039288351 -6.8424298042432055 1.2711741284269198 1.0927605849363653 0.43277399772406255 0.9285335702702207 0.0816066423065458 0.16598141644974812 0.5199576952869631 0.050319793435380095 0.1160063356343135 1.4373753600093817e-07 6.8424298042432055 -0.6599865872123027 down EK(ub)QPPIDNIIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKQPPIDNIIR 11 1 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 1 4563910.0 1738200.0 1872300.0 953410.0 True False 2278797.0327527453 1592960.1381682374 854760.2789545027 1.0 0.6990355504561855 0.37509276458990637 21.119841002097157 -7.052626910487018 0.26372701702173096 1.0909394553920584 3.09838516299042e-14 0.9999806964700746 0.0011211155633772236 0.07286797147250237 0.009524234284089788 0.007068501549972208 0.02969539151007505 8.858763131104323e-08 7.052626910487018 -1.0909394553920273 down EK(ub)QPPIDNIIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKQPPIDNIIR 11 1 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 1 11491800.0 3230900.0 4471300.0 3789600.0 True False 3128336.8480052426 6256713.407521467 2796990.0744369035 1.0 2.000012694128833 0.894082130644077 21.57696443452125 -6.668537415985789 1.9423558523821742 1.6390928876065254 0.8985581148289646 0.2726885964365151 0.4249249693349871 0.4644719835595426 3.376860826084122 0.17620034698790585 0.4716974726966018 2.1451742935998364e-07 6.668537415985789 -0.7405347727775607 EK(ub)QPPIDNIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKQPPIDNIIR 11 1 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 1 5241900.0 1738200.0 2090700.0 1413000.0 True False 2380859.5130887753 1998325.9609796403 1079278.5016484715 1.0 0.8393296412467192 0.4533146520049326 21.18305106362005 -6.956308209221248 0.48467061768544006 1.008870225900337 0.26755243533277756 0.999607826923142 0.004543214079194331 0.08104723356186434 0.026211885637513175 0.00549530897108533 0.031838959166958704 1.1058387160756124e-07 6.956308209221248 -0.7413177905675594 down EK(ub)QPPIDNIIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKQPPIDNIIR 11 1 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 1 11316200.0 3230900.0 5523800.0 2561500.0 True False 2686636.503138605 5494042.193011542 3097097.8069621483 1.0 2.044951814878286 1.1527788754987995 21.357369709955528 -10.266624001951044 4.264838179172852 0.999556081911373 1.5988653451826096 0.37529565394279085 0.3642280773550234 37927280.0820244 91302366.97841483 97408.61245855942 0.1246849621052942 5.4122269318584575e-11 10.266624001951044 0.5993092632712366 EK(ub)QPPIDNIIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKQPPIDNIIR 11 1 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 1 22565400.0 3113400.0 3198000.0 16254000.0 True False 4030357.6742890715 3020028.488732069 13295938.780123778 1.0 0.7493202174084418 3.2989476008401892 21.942476445800875 -6.88273297160569 1.0643975585834569 0.8382051044106787 3.4894130406799944 0.9758256147922302 0.1783980024732301 0.1252386142675512 0.25786829712755227 0.12877172864596834 0.31369342819954055 1.3099871283535144e-07 6.88273297160569 2.6512079362693157 up EK(ub)SAIYQLEEEYENLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKSAIYQLEEEYENLLK 17 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 78680600.0 6410600.0 12833000.0 59437000.0 True False 9725348.877636878 10542850.885313354 47689250.89783746 1.0 1.0840588875486303 4.903603099267455 23.213318574179674 -6.911648669452251 0.884442468498583 0.8878171008138801 5.4150095597478245 0.9915288012491675 0.16757439447460165 0.10333755994982949 0.13293182121582459 0.13832382404016894 0.38633702628778266 1.22560727599362e-07 6.911648669452251 4.5271924589339445 up EK(ub)SAIYQLEEEYENLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKSAIYQLEEEYENLLK 17 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 77618500.0 6410600.0 9588900.0 61619000.0 True False 8298648.071817807 9055269.28567947 50404974.26433166 1.0 1.0911740330851176 6.073877796493968 22.984444896272123 -6.910866143525019 0.8898205240083937 0.8499199391087435 6.729872111524952 0.9912442384557992 0.22182711364372754 0.10384790915948618 0.13568282365092213 0.18239422038741065 0.5065607631368605 1.227817605782607e-07 6.910866143525019 5.879952172416209 up EK(ub)VESELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKVESELR 8 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 6914560.0 4713700.0 1284900.0 915960.0 True False 4564066.173648927 1797967.2706649797 676042.5977890071 1.0 0.39393979014715336 0.14812287378570532 22.12188827850183 -9.81736022962893 0.24134385064001557 1.5176141519247073 2.6900556695647124e-14 0.9991368809157154 0.010517428797872784 1.2572224467532727 0.1054550186379186 0.5677586349536354 0.11266383945829991 1.522789138086145e-10 9.81736022962893 -1.5176141519246804 EK(ub)VLATVTKPVGGDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKVLATVTKPVGGDK 15 2 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 16583130.0 4045200.0 8345130.0 4192800.0 True False 5303296.373772519 7100069.133061961 3758969.276177551 1.0 1.3388030071589798 0.7087986435696022 22.338457944810962 -6.760648753525422 1.610117985774868 1.1966408972228588 0.7064314523594065 0.6935512372429369 0.14251471339295999 0.2818422351707765 1.4402412071629156 0.06983276670446233 0.16770578255298493 1.7352068221107714e-07 6.760648753525422 -0.4902094448634523 EK(ub)VLATVTKPVGGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKVLATVTKPVGGDK 15 2 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 32318300.0 6212100.0 10286600.0 15819600.0 True False 6014900.285831627 14394093.023910327 11675972.18217278 1.0 2.3930725930430254 1.9411746874135332 22.520109390128912 -10.207682987716218 5.043770805520819 0.9998822796779877 2.167123640229285 0.898927531830186 0.18448654744093196 0.0002442395833110286 3.836707055034808e-05 0.1786460087375129 0.05954277715266922 6.198933997679372e-11 10.207682987716218 1.167241360551297 EK(ub)VLATVTKPVGGDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKVLATVTKPVGGDK 15 2 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 30664000.0 8744800.0 4345200.0 17574000.0 True False 13266500.930514915 3569765.110797446 14100491.19704218 1.0 0.26908113371374803 1.0628643732733598 23.66128457102681 -12.06622605058867 15.006286536593162 0.9399160295581436 0.6993754781564946 0.0 0.36862469752053995 0.0 0.0 0.0 0.1073256627598686 8.585665206948404e-13 12.06622605058867 -0.24054055140164898 EK(ub)VLATVTKPVGGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKVLATVTKPVGGDK 15 2 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 11475000.0 4045200.0 3710500.0 3719300.0 True False 5540819.757419571 3546557.8410173412 2840877.941387943 1.0 0.6400781827036036 0.5127179850208619 22.401668006333853 -13.999999999999998 0.1447441232719701 2.7278421581703114 0.36376126640767015 0.9995847158412232 0.004205022819002219 11.941840391788977 0.11952296193746663 5.814227620844233 0.13363505137429732 1.0000000000000041e-14 13.999999999999998 -2.364080891762641 EK(ub)VLATVTKPVGGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKVLATVTKPVGGDK 15 2 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 24004800.0 6212100.0 14465200.0 3327500.0 True False 5165636.392691622 14387273.096482588 4023264.865378312 1.0 2.785188891118586 0.7788517347195507 22.30051466556319 -6.671998885128233 1.9300731157258573 2.1375352420782767 0.786863815217163 0.2879103874950367 0.7579666756467998 0.4566156162833942 3.2811433397213197 0.31592521216644304 0.8419448171089646 2.128144509108039e-07 6.671998885128233 -1.3506714268611137 EK(ub)VLATVTKPVGGDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKVLATVTKPVGGDK 15 2 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 25439600.0 8744800.0 11556800.0 5138000.0 True False 11320315.985778604 10913653.920756334 4202936.72033198 1.0 0.9640767920671872 0.37127379885967954 23.432410893119258 -6.919303501202382 0.8298821573122113 1.0134112942592102 0.2771957847312623 0.993985069632518 0.02235864899460872 0.09858349098528033 0.10775282634219249 0.01919349705160403 0.05711584955024677 1.2041941104407866e-07 6.919303501202382 -0.7362155095279479 down EK(ub)VLATVTKPVGGDK(ub)NGGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKVLATVTKPVGGDKNGGTR 20 3 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 2 4808300.0 1314400.0 1895500.0 1598400.0 True False 1723191.1286677083 1612698.7886011298 1433012.9009354608 1.0 0.935879231137868 0.8316041541157423 20.716651297055673 -6.963879687875743 0.37678507426627283 1.0074267033043764 0.7563879851760283 0.9998881496764672 0.0007339019336762465 0.07834319670478392 0.016213169613158114 0.0013618755232070706 0.008824991243919462 1.0867266366093823e-07 6.963879687875743 -0.2510387181283481 EK(ub)VLATVTKPVGGDK(ub)NGGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKVLATVTKPVGGDKNGGTR 20 3 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 2 7854200.0 1715800.0 2536200.0 3602200.0 True False 1661332.868181437 3548917.886108281 2658675.756316395 1.0 2.1361871266611803 1.6003269466562053 20.66390973302888 -10.126058068215253 5.544768707816375 0.9999876166354292 1.8682570366588565 0.7778033842074239 0.21876400241526583 3.3489717723372336e-05 5.278177319325456e-06 0.21182034974712918 0.07060577817524992 7.480694716940748e-11 10.126058068215253 0.8682694200234272 EK(ub)VLATVTKPVGGDK(ub)NGGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKVLATVTKPVGGDKNGGTR 20 3 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 2 4709300.0 1314400.0 1775800.0 1619100.0 True False 1800369.2003244094 1697339.2842146887 1236701.926411212 1.0 0.9427728956420962 0.6869157316112551 20.779861358578565 -6.942327763609466 0.6375429122256194 1.0027967756302931 0.612923220004964 0.9984531391964618 0.0053536443689049945 0.08672064209394255 0.04989343162512652 0.00530833316907305 0.021805304397452985 1.142016125791835e-07 6.942327763609466 -0.3898735556253291 EK(ub)VLATVTKPVGGDK(ub)NGGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKVLATVTKPVGGDKNGGTR 20 3 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 2 6976600.0 1715800.0 3950800.0 1310000.0 True False 1426763.7228280748 3929516.2562275967 1583914.943244357 1.0 2.7541464598207366 1.1101452314085918 20.444315008463157 -6.630872771316226 2.076880192922918 2.1549445928590893 1.1167472639401166 0.12062357387059086 0.752275209483668 0.5568752526349419 4.5784973626450105 0.2961036140351683 0.8335082165559675 2.3395225127923954e-07 6.630872771316226 -1.0381973289189728 EK(ub)VNTHFSFPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKVNTHFSFPLR 12 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2;A0A0C4DG73 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34;Ubiquitin carboxyl-terminal hydrolase 1 12832800.0 3763000.0 3631300.0 5438500.0 True False 3643545.6247620573 5081297.026979336 4013993.698497229 1.0 1.3946022776402507 1.1016724125032369 21.79691162567187 -10.584469652300207 5.7997255168068245 0.9990345511683274 1.2481373450716093 0.48894691424805137 0.11958811666799593 0.0014984480061522563 0.00010735876116057443 0.1162218925282967 0.03859689868828816 2.6033367414026826e-11 10.584469652300207 0.24910279390328194 EK(ub)VNTHFSFPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKVNTHFSFPLR 12 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2;A0A0C4DG73 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34;Ubiquitin carboxyl-terminal hydrolase 1 15363500.0 4571700.0 4508300.0 6283500.0 True False 6261981.035547082 4309108.39904554 4799466.71274464 1.0 0.6881382065171124 0.7664454244590876 22.578187708595454 -10.422287266783735 5.697553197583801 1.0001393635311275 0.7272918154881001 0.9417615916390503 0.03196878785579427 5.662208720871338e-05 5.741261094044997e-06 0.030969359888082745 0.010317881913660492 3.781923442884792e-11 10.422287266783735 -0.27284754804302747 EK(ub)VNTHFSFPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKVNTHFSFPLR 12 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2;A0A0C4DG73 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34;Ubiquitin carboxyl-terminal hydrolase 1 12952500.0 3763000.0 5738900.0 3450600.0 True False 3129101.2291654255 5707983.406617538 4172104.5062282225 1.0 1.8241606738110983 1.3333235969936903 21.577316901106148 -10.093530844696954 4.29429359816533 0.9999269761706501 1.5787421354503786 0.649574998646971 0.20038339774962943 140496774.49994284 239097457.91421342 139075.6122823661 0.07333283807138992 8.06248937474308e-11 10.093530844696954 0.5788151592797285 EK(ub)VNTHFSFPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKVNTHFSFPLR 12 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2;A0A0C4DG73 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34;Ubiquitin carboxyl-terminal hydrolase 1 24679000.0 11490000.0 9010100.0 4178900.0 True False 14874031.501760596 8508680.014485558 3418383.0791349346 1.0 0.5720493474468177 0.2298222293485334 23.826292396961808 -7.894052577134072 0.29599560685745463 1.1193735453535907 7.268735149146834e-12 0.9993370321221995 0.008112530633001701 0.11034978007521595 0.051342445292365174 0.049910038027264486 0.08689781573587292 1.2762842882383779e-08 7.894052577134072 -1.119373545346322 down EK(ub)VNVDIINFGEEEVNTEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKVNVDIINFGEEEVNTEK 19 1 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 1 22474700.0 6662300.0 6879800.0 8932600.0 True False 8734339.817804985 5853360.657250364 8008340.239549606 1.0 0.6701549034442497 0.9168798565891121 23.058267230958148 -9.93757510520985 6.621125664510146 1.0000000190736915 0.7935173800166774 0.4828982299848493 0.1007250403361793 2.8370342883539513e-08 4.609255090612314e-09 0.09752660966156748 0.032508866980672554 1.1545822984213852e-10 9.93757510520985 -0.20648263905701414 EK(ub)VNVDIINFGEEEVNTEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKVNVDIINFGEEEVNTEK 19 1 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 1 179078700.0 34649000.0 32947000.0 111482700.0 True False 33549086.4609037 46102908.916335195 82282036.46068892 1.0 1.3741926764551708 2.4525864975958727 24.99977014669459 -6.952350249914895 0.5324225072271783 0.9832824538486278 2.892654445871233 0.9993730180295219 0.015419557085713059 0.08255560834101709 0.0321618991346024 0.0171419935724689 0.08920604792782892 1.1159628827605147e-07 6.952350249914895 1.9093719920226053 up EK(ub)VNVDIINFGEEEVNTEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKVNVDIINFGEEEVNTEK 19 1 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 1 350561900.0 55002400.0 130920000.0 164639500.0 True False 83442662.01406021 107556303.1173711 132098430.66094354 1.0 1.2889845616292503 1.583104223576721 26.31428184811455 -6.97090565827008 0.2355536555332027 0.8883915867816707 1.9921577876311511 0.9999886095334057 0.0008034071994305765 0.07600991568371161 0.007971043020326545 0.007257462341239043 0.028906018212182815 1.069287135090972e-07 6.97090565827008 1.1037662008494804 EK(ub)VNVDIINFGEEEVNTEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKVNVDIINFGEEEVNTEK 19 1 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 1 44898600.0 6662300.0 6457300.0 31779000.0 True False 9125532.35188779 6171995.134564432 24273454.70904937 1.0 0.6763435706068849 2.659949444377121 23.12147729248104 -6.865052206676486 1.1600331235294519 0.8214465169187541 2.7656585319142617 0.959485994452373 0.17489289447348766 0.14168251075785107 0.35947797249948843 0.1173297115921848 0.27561869416506113 1.364419109479261e-07 6.865052206676486 1.9442120149955076 up EK(ub)VNVDIINFGEEEVNTEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKVNVDIINFGEEEVNTEK 19 1 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 1 154381800.0 34649000.0 38189000.0 81543800.0 True False 28812178.710962772 37983268.277077034 98594231.56406812 1.0 1.318306007265766 3.4219637658485684 24.780175422128867 -6.9338263096944885 0.7146946025981653 0.9721007655145025 3.899151705508666 0.9972381406283297 0.05647310878391493 0.09069930759569443 0.06830214836711998 0.05267513540723319 0.18650259745804268 1.1645916992557287e-07 6.9338263096944885 2.9270509399941633 up EK(ub)VNVDIINFGEEEVNTEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKVNVDIINFGEEEVNTEK 19 1 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 1 453129500.0 55002400.0 122189100.0 275938000.0 True False 71201691.05939406 115389169.17214864 225720115.36297488 1.0 1.6205959079805403 3.1701510456357944 26.085408170207 -6.955488802801084 0.4949389297569501 0.9675585102680256 3.88944899173506 0.9995645617090045 0.019043707021844093 0.08135382880277352 0.027399569177156927 0.022551811442610186 0.12780781203481997 1.1079271301409482e-07 6.955488802801084 2.9218904814670346 EK(ub)VSGQVGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKVSGQVGSR 10 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 22023000.0 4840700.0 6649300.0 10533000.0 True False 6346204.577405484 5657250.3587683905 9443146.199670427 1.0 0.8914383849064698 1.4879990212245984 22.59746259830919 -6.8597940990939765 1.1869175885191285 0.9411368194954454 1.5167528860334865 0.9533708763787249 0.05602434112806471 0.14701848581660054 0.3936981543052324 0.036819739563578556 0.08592032477291954 1.3810388659592673e-07 6.8597940990939765 0.5756160665380411 EK(ub)VSGQVGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKVSGQVGSR 10 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 24557200.0 5286000.0 9118200.0 10153000.0 True False 5118198.823410114 12759144.81078482 7493624.7165288795 1.0 2.4928974529918233 1.4641136413563716 22.28720476124556 -10.454298980288264 5.688525345127498 0.9992302863865541 1.9785055471740975 0.5467306549797356 0.41999923235707437 0.004102760219819038 0.0003935777160295159 0.40694066831930437 0.13555416936157005 3.5131849992268596e-11 10.454298980288264 0.9792752607875435 EK(ub)VSGQVGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKVSGQVGSR 10 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 20664400.0 4840700.0 5600700.0 10223000.0 True False 6630437.604998753 5353242.554961819 7808537.949293934 1.0 0.8073739433014129 1.1776806320305313 22.66067265983208 -6.765362116785042 1.592387934972228 0.8888590051860148 1.1793987402065995 0.7124154927672322 0.08109359338306842 0.27400919671804863 1.370485613837871 0.040160128246477675 0.09600326015382253 1.7164765840560732e-07 6.765362116785042 0.2905397350205847 EK(ub)VSGQVGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKVSGQVGSR 10 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 18174000.0 5286000.0 7077300.0 5810700.0 True False 4395543.209505305 7039173.180165941 7025690.504358764 1.0 1.6014341901915152 1.5983668387483485 22.067610036679838 -10.069435535698098 4.739820150843149 0.9999766991897623 1.5999005144810095 0.9999803921212049 0.0012522410209671194 869030.1230640592 0.017783547097435876 220.99547185823502 0.000428675403413797 8.522450045867433e-11 10.069435535698098 0.5999238152912472 EK(ub)VVPLYGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKVVPLYGR 9 1 Q99942;A0A140TA09 Q99942 RNF5 E3 ubiquitin-protein ligase RNF5 1 8250600.0 3311200.0 3245200.0 1694200.0 True False 3206087.768459246 4541025.283494429 1250438.1950894564 1.0 1.4163758485241704 0.39001995122871547 21.61238248994692 -6.7965487594031035 1.4697673396893762 1.2307459333521698 0.376996756687312 0.8219514744705589 0.17784920306565408 0.22571011299592195 0.9628958995814988 0.09520733266562115 0.2219179068359883 1.597538159107551e-07 6.7965487594031035 -0.8537491766648577 down EK(ub)VVPLYGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKVVPLYGR 9 1 Q99942;A0A140TA09 Q99942 RNF5 E3 ubiquitin-protein ligase RNF5 1 11140300.0 4749900.0 2678600.0 3711800.0 True False 7205945.564204196 2200582.902002676 2978161.103060268 1.0 0.30538433608687715 0.41329220107551107 22.780756322594666 -10.08687669842207 5.37025625563943 1.0000079969138327 0.35933826858836876 0.9791663020548659 0.0440532014108388 4.217907936389428e-06 7.17251838076874e-07 0.042654860422109656 0.01421810961737359 8.186971934066799e-11 10.08687669842207 -0.6406697283254639 EK(ub)YEITEQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKYEITEQR 9 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 11778600.0 3879100.0 5221000.0 2678500.0 True False 5085537.665257831 4442047.151298603 2401354.5139862574 1.0 0.8734665720096276 0.47219284804264866 22.27796887949253 -6.950196389695604 0.556686736592996 1.0053419911594585 0.3212487772027089 0.9992165818284684 0.006297567298093454 0.08340704642193701 0.03563722986668746 0.006777970532723558 0.033333205243623494 1.1215111877877206e-07 6.950196389695604 -0.6840932139567497 down EK(ub)YEITEQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKYEITEQR 9 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 25962700.0 6628900.0 8809500.0 10524300.0 True False 6418469.1979764085 12327179.290935587 7767670.107767651 1.0 1.9205793329696208 1.2102060270409358 22.613797825577066 -10.207711427881945 4.758355436150799 0.9999039857318245 1.5653926800073177 0.4578854802187958 0.290008687743764 0.00029546219824892224 4.919496491635479e-05 0.28084707718003066 0.09359990148956486 6.198528068188777e-11 10.207711427881945 0.5654886942754932 EK(ub)YEITEQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKYEITEQR 9 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 43620000.0 12376800.0 14311500.0 16931700.0 True False 18776510.46528187 11757501.008740133 13585142.073572244 1.0 0.626181367963977 0.7235179347457258 24.162425633368894 -9.990982719421753 6.879731946856885 1.0000000371805498 0.6748496513548524 0.937021212517331 0.039737486988273236 2.2667056431316395e-08 3.333455892583007e-09 0.03847566034473824 0.012825218777142617 1.0209801076998544e-10 9.990982719421753 -0.32515038582569733 EK(ub)YEITEQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKYEITEQR 9 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 12855400.0 3879100.0 7397900.0 1578400.0 True False 5313308.09873585 7071036.316416174 1205614.4281683986 1.0 1.3308161666925593 0.22690467139581835 22.34117894101542 -6.826370550186756 1.3440502141134383 1.1772572340547964 0.1993420903549987 0.8984178057760085 0.1474300285527829 0.18533345818187136 0.6560436092837701 0.08615544258221236 0.19832336491123423 1.4915212657677887e-07 6.826370550186756 -0.9779151436997977 down EK(ub)YEITEQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKYEITEQR 9 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 21554100.0 6628900.0 12187600.0 2737600.0 True False 5512224.060062373 12121942.979750806 3310019.502767748 1.0 2.199102004502633 0.6004871113186016 22.394203101011342 -6.705966105219003 1.8095088724644026 1.740194868190907 0.6046577880970453 0.4459676508316647 0.5056250925491028 0.38323821388262164 2.4434846911432535 0.22257733290279882 0.5682502471437081 1.9680398806008728e-07 6.705966105219003 -1.1355370800938616 EK(ub)YEITEQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKYEITEQR 9 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 33749100.0 12376800.0 7574100.0 13798200.0 True False 16022011.583201963 7152594.6768310005 11287069.181487868 1.0 0.44642301247179417 0.7044726639270206 23.933551955461343 -10.41410124827899 6.059832943581395 1.00011953153574 0.5754478381994121 0.7830360957633462 0.10534832906139228 0.0001701742186549364 1.645337477690684e-05 0.10203151326837488 0.03400102700046255 3.8538850050016295e-11 10.41410124827899 -0.4246716933363279 EK(ub)YIDQEELNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKYIDQEELNK 11 1 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 100198500.0 55535000.0 35381000.0 9282500.0 True False 72806922.8017051 30102292.714057796 8322035.944027417 1.0 0.4134537150545911 0.11430281110345895 26.117572298932853 -8.794108751606045 0.3197817062819059 1.1960819254126553 2.1700279113685868e-17 0.9983665660346284 0.014867942977080183 0.3300540444578991 0.10395323080572541 0.1687944956541898 0.09078179270133581 1.60653890950933e-09 8.794108751606045 -1.1960819254126553 EK(ub)YIDQEELNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKYIDQEELNK 11 1 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 121083300.0 53808000.0 53189000.0 14086300.0 True False 52099894.49301011 74427645.0769707 10396675.45005819 1.0 1.4285565412604846 0.19955271601275587 25.634777115130575 -6.812518446181669 1.4040454557712443 1.2328681687406047 0.17681503365926063 0.8662811700676223 0.18625261511202787 0.203380202797693 0.7897307406520139 0.1042959861731841 0.2409804348576087 1.5398611207587173e-07 6.812518446181669 -1.056053135081344 down EK(ub)YIDQEELNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKYIDQEELNK 11 1 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 160689000.0 84616000.0 35242000.0 40831000.0 True False 128368658.25821619 28952789.752997205 32760734.953136917 1.0 0.22554407084911704 0.2552082057852317 26.935717764558316 -10.586159203486329 6.399071544131938 1.0017076612899494 0.24037613831720647 0.9988575660397169 0.012110332375758167 0.0002955125438202053 1.911137887275424e-05 0.011744675497274164 0.003908592967362322 2.5932285632347743e-11 10.586159203486329 -0.7613315229727429 EK(ub)YIDQEELNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKYIDQEELNK 11 1 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 100857100.0 55535000.0 33877000.0 11445100.0 True False 76067790.27694468 32380202.123741988 8742003.09923349 1.0 0.42567559811916966 0.11492384710277427 26.180782360455744 -8.662555052242746 0.32943715552664365 1.1687390507530178 3.3154899508713803e-15 0.9982507077625928 0.01533423786164783 0.2551242399202868 0.10165449740587897 0.13999037694321725 0.08981210333743946 2.1749283172514778e-09 8.662555052242746 -1.1687390507530144 EK(ub)YIDQEELNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKYIDQEELNK 11 1 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 135531800.0 53808000.0 72621000.0 9102800.0 True False 44743736.09857386 72229776.25886005 11006153.39340818 1.0 1.6142991747433058 0.24598199330428697 25.41518239056485 -6.78462252168613 1.5175382151512737 1.3457328317262363 0.23345806698233304 0.7835425194553179 0.26034595686571704 0.2434363862796657 1.10748743482325 0.13507726259054093 0.3175601419354835 1.6420163542404121e-07 6.78462252168613 -1.1122747647439033 EK(ub)YIDQEELNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKYIDQEELNK 11 1 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 160182000.0 84616000.0 43414000.0 32152000.0 True False 109537080.03072013 40997972.736026905 26300665.907379106 1.0 0.3742839659823765 0.2401074220711651 26.706844086650765 -13.99999999999999 0.21639771084104797 4.717309454234108 0.16581096023108077 0.9994945496069437 0.007445053082372333 12.904132907424865 0.14739628473169944 20.45998201186654 0.07606147015417715 1.0000000000000246e-14 13.99999999999999 -4.551498494003027 EK(ub)YLNVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKYLNVSR 8 1 O43324 O43324 EEF1E1 Eukaryotic translation elongation factor 1 epsilon-1 1 5311300.0 1691100.0 1556200.0 2064000.0 True False 2189162.286564611 1469596.101990256 1688373.178428419 1.0 0.6713052344312265 0.7712416702911205 21.06194747740334 -10.437117417264098 8.68043229330816 1.0000036233825382 0.7212734523611737 0.9120619830259257 0.04079887909485321 2.8609551195604624e-06 1.855410530630249e-07 0.039503858504404764 0.013167781606524705 3.654959615806225e-11 10.437117417264098 -0.27873017102136455 EK(ub)YNADYDLSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKYNADYDLSAR 12 1 Q13505-3;Q13505 Q13505-3 MTX1 Metaxin-1 1 9788700.0 3502300.0 3251900.0 3034500.0 True False 4591549.216321452 2766729.1958069173 2720519.048979391 1.0 0.6025698659555042 0.5925056926992828 22.13054957908585 EK(ub)YNADYDLSAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKYNADYDLSAR 12 1 Q13505-3;Q13505 Q13505-3 MTX1 Metaxin-1 1 8251500.0 3502300.0 2400100.0 2349100.0 True False 4797194.956098737 2294055.645930662 1794290.9612331407 1.0 0.47820771657699646 0.3740291936545199 22.193759640608743 -13.999999999999998 0.22650309386507037 4.241505322951146 0.3216614322982738 0.9995052227011727 0.006091473894223568 13.184771199045397 0.15071789874441013 19.183440545275104 0.05527934895497796 1.0000000000000041e-14 13.999999999999998 -3.919843890652872 EK(ub)YNADYDLSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKYNADYDLSAR 12 1 Q13505-3;Q13505 Q13505-3 MTX1 Metaxin-1 1 8651000.0 2016900.0 3790400.0 2843700.0 True False 1677141.7138197576 3769980.3628645074 3438304.522216771 1.0 2.2478603518114313 2.050097790714354 20.67757316710361 -10.166493164985349 4.581826013475498 0.9998293203879562 2.1489790712763814 0.9782639200820434 0.08073622756844104 28284689.615404375 17.38484346208093 52015.61559921425 0.02763815814178504 6.815643012395216e-11 10.166493164985349 1.1491497508884252 EKAENEK(ub)IQNEQLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKAENEKIQNEQLEK 15 2 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 3874970.0 1607600.0 1495700.0 771670.0 True False 1556567.617955751 2092940.809972458 569546.4773962224 1.0 1.3445871453506972 0.36589896309433123 20.569936818775375 -6.811539655531517 1.4079521704396312 1.1874540493368506 0.3481478766323249 0.8638507997617635 0.14956146756364985 0.20469567224364904 0.7994344161001251 0.08351810789377166 0.19307228942448226 1.5433354945626988e-07 6.811539655531517 -0.8393061727045257 down EKAENEK(ub)IQNEQLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKAENEKIQNEQLEK 15 2 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 8973200.0 3952000.0 2665500.0 2355700.0 True False 5995472.92990062 2189820.6993534467 1890094.8624600102 1.0 0.36524569870583085 0.3152536729894534 22.51544212892056 -13.999999999999998 0.3603024114362022 9.32093561433713 0.3092602300142198 0.9997738370297369 0.004687236435352277 21.72949271087618 0.19401551249881485 139.05070590480688 0.014411652640353712 1.0000000000000041e-14 13.999999999999998 -9.01167538432291 EKAENEK(ub)IQNEQLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKAENEKIQNEQLEK 15 2 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 3322850.0 1908200.0 1034200.0 380450.0 True False 2613713.107166032 988505.6243579398 290595.5456137025 1.0 0.37819974259904365 0.11118111808712865 21.3176693624913 -9.25292024011892 0.2936803328030552 1.3060830916404822 8.483660259923972e-22 0.9986718012971738 0.013570815789104984 0.6695571044452953 0.11148442828971121 0.3039122590669799 0.09312967123589382 5.585727693923265e-10 9.25292024011892 -1.3060830916404822 EKANGTTVHVGIHPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKANGTTVHVGIHPSK 16 1 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 5598610.0 1266300.0 506610.0 3825700.0 False True 1226101.9996375751 708902.0149362485 2823634.4014601144 1.0 0.5781754006973268 2.3029359729408774 20.225647571395474 -6.842052368602018 1.2728968283565831 0.7756316490832854 2.3619840399060377 0.9279153350494671 0.19710059844697117 0.16641569080436722 0.5228948617997005 0.12137731193464905 0.2797919655307837 1.4386250938331583e-07 6.842052368602018 1.5863523908227521 up EKANGTTVHVGIHPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKANGTTVHVGIHPSK 16 1 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 12116300.0 1798600.0 6409700.0 3908000.0 False True 2728607.695273092 5265838.955785321 3135582.0870627537 1.0 1.9298629718400362 1.1491509360230436 21.379733555812887 -10.12853606072822 4.256035638926217 0.9998964817331083 1.5395069539537205 0.3890233625635747 0.31872435416104056 45518498.97776217 36108428.87986663 39395.29210322043 0.1091078234331295 7.438132993716347e-11 10.12853606072822 0.5396104722206122 EKANGTTVHVGIHPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKANGTTVHVGIHPSK 16 1 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 2916700.0 1266300.0 938840.0 711560.0 False True 1052984.5566016955 933782.2825748496 860343.9061182844 1.0 0.886795800299723 0.8170527295242377 20.00605284682975 EKANGTTVHVGIHPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKANGTTVHVGIHPSK 16 1 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 10367400.0 1798600.0 5963200.0 2605600.0 False True 2328323.1557064084 5631342.677925914 2131407.535713703 1.0 2.418625895689886 0.9154259925173652 21.150859877905337 -6.659253619836897 1.9754829775549843 1.9137252031151568 0.9217068092666744 0.23240182812168375 0.6041296584818119 0.4862578091951771 3.6471267797204203 0.24713612613850242 0.6696749499424068 2.1915247522086006e-07 6.659253619836897 -0.9920183938484824 EKDFSPEALK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKDFSPEALKK 11 2 A0A087WZK9;B3KS98;O15372;E5RJT0;E5RGU4 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 13990900.0 1099200.0 1594700.0 11297000.0 True False 1422936.0684713002 1505953.5431460368 9241061.917008642 1.0 1.0583423784906405 6.494361989809263 20.44043941335907 -6.909246652803509 0.9008563876806949 0.8276539131731155 7.185657067212004 0.9906340053587724 0.24934150878898656 0.10491811385201057 0.14148758421574786 0.20338191717552165 0.5585338234325944 1.232404703652846e-07 6.909246652803509 6.358003154038888 up EKDLEDLFYK(ub)YGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKDLEDLFYKYGR 13 2 Q13242;H0YIB4;S4R3G0 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 9444600.0 7213500.0 0.0 2231100.0 True False 9456968.355633374 0.0 2000247.1742224137 1.0 0.0 0.21151040153696787 23.17294633858982 -10.023027907528796 4.585013798079116 1.0000278224745733 0.10575520085896789 0.9597318401434215 0.0863487600427846 1050426411.4216403 2360606144.9263883 486251.2255873086 0.031600422975771245 9.483575204008923e-11 10.023027907528796 -0.8942726216156054 EKDLEDLFYK(ub)YGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKDLEDLFYKYGR 13 2 Q13242;H0YIB4;S4R3G0 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 19961800.0 6680100.0 7027900.0 6253800.0 True False 6468043.882001873 9834177.12001434 4615742.170021501 1.0 1.520425232020943 0.7136225811431754 22.624898036034903 -6.7325453243317765 1.7140363438982433 1.3122950725769813 0.7138802033791447 0.5710261219723096 0.21873310201043597 0.3314672876305019 1.908956172440432 0.10108331031167628 0.25010349671015863 1.8512056865025565e-07 6.7325453243317765 -0.5984148691978366 EKDLEDLFYK(ub)YGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKDLEDLFYKYGR 13 2 Q13242;H0YIB4;S4R3G0 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 20521700.0 6680100.0 10790000.0 3051600.0 True False 5554799.128606958 10731872.12835268 3689675.450995786 1.0 1.93200003814432 0.6642320209193755 22.40530331146918 -6.7096981453633 1.7962854348085047 1.5731474457094838 0.6672363602829856 0.46367618868105687 0.39275774160258825 0.3756773527423925 2.3627456353127556 0.17401246796399417 0.4422345965832163 1.9512003025051298e-07 6.7096981453633 -0.9059110854264982 EKDPEIFCDPFTSATTTTNK(ub)EADPSNFANFSAYPSEEDMIEWAK ddPTM_RPMI8226_Bortezomib_8h_R1 2 EKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWAK 44 2 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 840948000.0 265822000.0 451455000.0 123671000.0 True False 403271408.1913058 370889328.0159852 99227372.64307503 1.0 0.9197015223058932 0.24605605710584638 28.587175881870067 -6.929222652160494 0.7531458374265804 1.0105450384972565 0.11045866587497528 0.9963832426182955 0.020331903614911013 0.09304349650237662 0.07967242959142913 0.018438404155786854 0.06121593454738529 1.1770023984680461e-07 6.929222652160494 -0.9000863726222812 down EKDPEIFCDPFTSATTTTNK(ub)EADPSNFANFSAYPSEEDMIEWAK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 EKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWAK 44 2 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 431037000.0 265822000.0 93011000.0 72204000.0 True False 344111819.1349872 87834856.08675997 59063612.8756034 1.0 0.2552509132280178 0.17164075626369027 28.358302203962516 -13.999999999999998 0.3087257418394625 8.145584691302856 0.15287066327566148 0.9996691918279844 0.006772403562587304 17.17949727463823 0.17674418616128915 78.80194685878296 0.029126021384127683 1.0000000000000041e-14 13.999999999999998 -7.992714028027195 EKEEEELMEK(ub)PQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKEEEELMEKPQK 13 2 Q13123;D6REL4;E7EQZ7 Q13123 IK Protein Red 1 2513960.0 874990.0 922530.0 716440.0 True False 1147120.3634152147 784892.1199937746 642309.6613777534 1.0 0.6842282161716564 0.5599322284415426 20.12958534567511 -13.999999999999998 0.12881356091547985 2.5004722086868685 0.38321271339575785 0.99965101956715 0.003460445874618293 11.938714145452048 0.11149236887720139 4.5404700626069285 0.15709621043607414 1.0000000000000041e-14 13.999999999999998 -2.1172594952911106 EKEEEELMEK(ub)PQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKEEEELMEKPQK 13 2 Q13123;D6REL4;E7EQZ7 Q13123 IK Protein Red 1 4396480.0 874990.0 872590.0 2648900.0 True False 1198497.4487156537 834036.088530743 2023284.3758079547 1.0 0.6959014300985967 1.6881841325370928 20.192795407198002 -6.8244622483942505 1.3526225390956608 0.8367939824104328 1.7119607399677006 0.8943045947140995 0.13494924364495123 0.18774864836249622 0.6737357368536582 0.07837815259173411 0.18045549055874802 1.4980894707368674e-07 6.8244622483942505 0.8751667575572678 EKEEEELMEK(ub)PQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKEEEELMEKPQK 13 2 Q13123;D6REL4;E7EQZ7 Q13123 IK Protein Red 1 14151300.0 1487500.0 2668200.0 9995600.0 True False 1925598.0730086095 2519712.324463699 8176503.363516992 1.0 1.308534922101801 4.246214969846635 20.876875172511003 -6.927009032452107 0.7709497235149232 0.9500239884761524 4.805799601950977 0.9959170129868443 0.09348253685324313 0.09422087502290519 0.08550911992915802 0.08369803244236143 0.27031264460473353 1.1830169510950872e-07 6.927009032452107 3.855775613474825 up EKEEFAVPENSSVQQFK(ub)EAISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKEEFAVPENSSVQQFKEAISK 22 2 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 1 28304100.0 7632800.0 9174500.0 11496800.0 True False 10006674.71614034 7805700.361920892 10307221.421092853 1.0 0.7800493753764806 1.0300346232368025 23.25445930096841 -6.6743790213121805 1.9219667740387973 0.8601364059066022 1.0290429244475296 0.29851713134279023 0.09333739905927722 0.4511517510747369 3.216989057082689 0.039039930003619605 0.10370853371481632 2.116513186923673e-07 6.6743790213121805 0.16890651854092742 EKEEFAVPENSSVQQFK(ub)EAISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKEEFAVPENSSVQQFKEAISK 22 2 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 1 49451300.0 20502300.0 10359000.0 18590000.0 True False 19851465.708891638 14495402.721471349 13720721.311954308 1.0 0.730193071586585 0.6911691818205989 24.242742195150754 -13.999999999999998 0.2723247904628608 3.1087078737435876 0.6785048010269571 0.9995883465172499 0.0027859824913775014 14.998418838994436 0.16521854788007184 17.5341197062376 0.016021452725638447 1.0000000000000041e-14 13.999999999999998 -2.4302030727166306 EKEEFAVPENSSVQQFK(ub)EAISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKEEFAVPENSSVQQFKEAISK 22 2 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 1 149626000.0 45054000.0 55190000.0 49382000.0 True False 68350211.8885988 45340913.29856183 39621626.05510055 1.0 0.663361707970432 0.5796854897784108 26.026442474466528 -13.999999999999998 0.1954978263233229 2.840187485700879 0.522866481864564 0.9994873126182184 0.004113168702201353 12.445421835341568 0.14021233260053403 8.741419586872219 0.055126133176281775 1.0000000000000041e-14 13.999999999999998 -2.317321003836315 EKEEFAVPENSSVQQFK(ub)EAISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKEEFAVPENSSVQQFKEAISK 22 2 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 1 36757200.0 7632800.0 14241900.0 14882500.0 True False 10454852.428664127 13612645.766334707 11367560.014708698 1.0 1.302040928766516 1.087299901387627 23.3176693624913 -10.257705790106245 3.724680883323448 0.9996727293677135 1.1946704150221852 0.5228421872028666 0.0876676577311701 62467070.67049295 112843765.94074616 242810.43693784872 0.03208307315431758 5.5245156716258425e-11 10.257705790106245 0.19499768565447173 EKEEFAVPENSSVQQFK(ub)EAISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKEEFAVPENSSVQQFKEAISK 22 2 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 1 57981000.0 20502300.0 25750400.0 11728300.0 True False 17048570.85589115 25611677.484145794 14180633.304467762 1.0 1.502277094111713 0.8317784185158037 24.02314747058503 -6.706224933031894 1.8087732960070482 1.309973057400877 0.8335292485701401 0.44712705441828315 0.21178599483796462 0.38270362940974795 2.4383030820817946 0.09326462293434234 0.23801703081231226 1.966867331282526e-07 6.706224933031894 -0.4764438088307369 EKEEFAVPENSSVQQFK(ub)EAISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKEEFAVPENSSVQQFKEAISK 22 2 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 1 116282000.0 45054000.0 57953000.0 13275000.0 True False 58323291.14711246 54727864.60521869 10859086.21300255 1.0 0.9383535038716385 0.18618781621242877 25.797568796558977 -6.923155527395062 0.8009784577930423 1.014785634818398 0.05563234668152774 0.9950134073955587 0.026125132212158047 0.09635070495335496 0.09625384754988425 0.022894078037404997 0.07079123247011089 1.1935605958941031e-07 6.923155527395062 -0.9591532881368702 down EKEEFAVPENSSVQQFK(ub)EEISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKEEFAVPENSSVQQFKEEISK 22 2 Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UMX0-2 UBQLN1 Ubiquilin-1 1 97402500.0 22987500.0 36702000.0 37713000.0 True False 30136835.11126667 31226204.663275473 33810820.528640516 1.0 1.0361474437507057 1.1219101277161094 24.845024581179622 -6.956572966472014 0.48131040372900186 0.9979666271033405 1.1636745274763134 0.9996211996277906 0.0009950199876253875 0.08094886611609903 0.025833413570402565 0.0012124616609570215 0.007074386771155036 1.1051647733805463e-07 6.956572966472014 0.1657079003729729 EKEEFAVPENSSVQQFK(ub)EEISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKEEFAVPENSSVQQFKEEISK 22 2 Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UMX0-2 UBQLN1 Ubiquilin-1 1 64675000.0 16076000.0 29423000.0 19176000.0 True False 15565676.179557504 41171757.33891803 14153230.33233114 1.0 2.645034938667756 0.909258946997668 23.891864913662737 -6.6582848807969945 1.9787425099016391 2.060358561522955 0.9164774384533014 0.22845724720802774 0.7007020904151601 0.4885075237020909 3.6750078672641115 0.2862607679468048 0.7767385839539919 2.1964186323707272e-07 6.6582848807969945 -1.1438811230696537 EKEEFAVPENSSVQQFK(ub)EEISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKEEFAVPENSSVQQFKEEISK 22 2 Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UMX0-2 UBQLN1 Ubiquilin-1 1 228940000.0 88811000.0 84577000.0 55552000.0 True False 134732779.95379657 69483573.5468829 44572122.85069347 1.0 0.5157139455647739 0.33081869806277603 27.005525654616275 -13.999999999999998 0.13343279029038557 3.303552560904885 0.0828299149208769 0.9996303621428488 0.005424775171577597 11.932932981472076 0.1139202483630681 7.188515502801146 0.22086484678330703 1.0000000000000041e-14 13.999999999999998 -3.220722645984008 EKEEFAVPENSSVQQFK(ub)EEISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKEEFAVPENSSVQQFKEEISK 22 2 Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UMX0-2 UBQLN1 Ubiquilin-1 1 93444500.0 22987500.0 37250000.0 33207000.0 True False 31486599.963829372 35604171.83072258 25364190.51963255 1.0 1.1307721974307585 0.8055550789469166 24.908234642702514 -6.797548041820578 1.4657705323823698 1.0723776247032881 0.8013256601468896 0.8249489268807155 0.055903260278836894 0.2242669397523135 0.9514724899138189 0.03000691642810176 0.06989593373268477 1.593866556835858e-07 6.797548041820578 -0.2710519645563986 EKEEFAVPENSSVQQFK(ub)EEISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKEEFAVPENSSVQQFKEEISK 22 2 Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UMX0-2 UBQLN1 Ubiquilin-1 1 75776000.0 16076000.0 21545000.0 38155000.0 True False 13367906.287553396 21428932.808652338 46133034.09121256 1.0 1.603013392501443 3.451029136415039 23.672270189097013 -6.950970349113986 0.5480861422286947 0.9741477566674186 4.1664275230504515 0.999275256044419 0.028072493579918426 0.08309840126717546 0.03436763786073983 0.03054469364297571 0.15325402994382661 1.1195143142291645e-07 6.950970349113986 3.1922797663830327 EKEEFAVPENSSVQQFK(ub)EEISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKEEFAVPENSSVQQFKEEISK 22 2 Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UMX0-2 UBQLN1 Ubiquilin-1 1 158072000.0 88811000.0 34664000.0 34597000.0 True False 114967590.22653276 32734917.92789503 28300700.99519765 1.0 0.2847317045037995 0.24616242664070628 26.776651976708724 -13.563033505227079 0.41991234979069125 9.999999999963487 0.24486839965609464 0.9998571842307896 0.004142409639696105 20.39603768675231 0.21562925110753411 166.1709190189524 0.009363779228273503 2.735057712194096e-14 13.563033505227079 -9.755131600307392 EKEEFAVPENSSVQQFK(ub)EEISKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKEEFAVPENSSVQQFKEEISKR 23 3 Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UMX0-2 UBQLN1 Ubiquilin-1 1 27089600.0 8235000.0 11681000.0 7173600.0 True False 10796164.74785345 9938240.332181366 6431344.6860301625 1.0 0.9205343345800034 0.595706423182258 23.364015561606678 -6.944377694294569 0.617503817073268 1.0035620753163659 0.49554368223787454 0.9986828004914748 0.0063473532639420965 0.08582526212470104 0.0459345072402675 0.006406904154679542 0.02746459423818746 1.1366383518887951e-07 6.944377694294569 -0.5080183930784914 EKEEFAVPENSSVQQFK(ub)EEISKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKEEFAVPENSSVQQFKEEISKR 23 3 Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UMX0-2 UBQLN1 Ubiquilin-1 1 39729000.0 12504000.0 15456000.0 11769000.0 True False 12107067.36434355 21627661.401975222 8686345.837568047 1.0 1.7863666527263833 0.7174607670186217 23.529346114603655 -6.709573550247126 1.7967978805153728 1.483651650409126 0.7200104731530339 0.463054230181258 0.3313924634409004 0.37592744916434406 2.365605563198306 0.1467890621781939 0.3730959906528648 1.9517601643381897e-07 6.709573550247126 -0.763641177256092 EKEEFAVPENSSVQQFK(ub)EEISKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKEEFAVPENSSVQQFKEEISKR 23 3 Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UMX0-2 UBQLN1 Ubiquilin-1 1 232423000.0 102930000.0 73220000.0 56273000.0 True False 156152335.1909592 60153318.92952892 45150616.884667955 1.0 0.3852220260168843 0.2891446793251803 27.218378903502057 -13.999999999999998 0.26127535177900346 5.530549861124229 0.2544556353579855 0.9995649474963277 0.00656830126351715 14.473863460465623 0.1617573408270978 34.6489094142559 0.041723390844733234 1.0000000000000041e-14 13.999999999999998 -5.2760942257662435 EKEEFAVPENSSVQQFK(ub)EEISKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKEEFAVPENSSVQQFKEEISKR 23 3 Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UMX0-2 UBQLN1 Ubiquilin-1 1 28649600.0 8235000.0 12095000.0 8319600.0 True False 11279702.042507233 11560602.907183614 6354681.827540428 1.0 1.0249032167354966 0.5633731993622697 23.42722562312957 -6.894149886657838 0.9974917577216508 1.0223882053799498 0.520290547557644 0.9834248473186905 0.027286317082978007 0.11584131203043929 0.20268750657615006 0.020720717313547125 0.05249267110602287 1.2759983516014771e-07 6.894149886657838 -0.5020976578223058 EKEEFAVPENSSVQQFK(ub)EEISKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKEEFAVPENSSVQQFKEEISKR 23 3 Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UMX0-2 UBQLN1 Ubiquilin-1 1 35978400.0 12504000.0 16955000.0 6519400.0 True False 10397630.02112264 16863660.049696002 7882576.397700188 1.0 1.6218753711603233 0.7581127989442636 23.30975139003793 -6.7135148885906215 1.7828141320315423 1.3809328203693512 0.7599349148909961 0.48175733556424405 0.2619149597497715 0.3680326021603929 2.2823832905958144 0.11682055220839677 0.2955056857932767 1.9341275512446074e-07 6.7135148885906215 -0.6209979054783551 EKEEFAVPENSSVQQFK(ub)EEISKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKEEFAVPENSSVQQFKEEISKR 23 3 Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UMX0-2 UBQLN1 Ubiquilin-1 1 230769000.0 102930000.0 64551000.0 63288000.0 True False 133244914.05363089 60958680.10511059 51770233.38971787 1.0 0.457493485121502 0.3885344049145502 26.989505225594506 -13.999999999999998 0.290833110289008 5.696779502130867 0.3699000626698118 0.9996293269109366 0.005264634997267785 16.0153952736915 0.17103678751674745 45.02665276699335 0.025946424682218288 1.0000000000000041e-14 13.999999999999998 -5.326879439461055 EKEFNK(ub)GPWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKEFNKGPWK 10 2 Q16531;F5GY55;F5H2L3 Q16531 DDB1 DNA damage-binding protein 1 1 13373300.0 1361300.0 6392200.0 5619800.0 True False 1784677.4828479525 5438508.676600443 5038317.00492812 1.0 3.0473341703856653 2.8230966397850636 20.767231951177422 -10.071556347857896 7.543886453907152 0.9999998085334466 2.9352154050853647 0.9900306263412924 0.091544588525534 2.952007214084949e-07 3.659229486225199e-08 0.08863767462252833 0.029545888899566976 8.480933388179014e-11 10.071556347857896 1.935215596551918 EKEFNK(ub)GPWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKEFNKGPWK 10 2 Q16531;F5GY55;F5H2L3 Q16531 DDB1 DNA damage-binding protein 1 1 21357600.0 7448200.0 5034000.0 8875400.0 True False 7211760.967938546 7044102.451963203 6550666.483707331 1.0 0.9767520697481925 0.9083310598936578 22.781920149110984 -6.951880470103602 0.5378044964543929 1.0010221394359815 0.8809131748970417 0.9993406828229512 0.000999052865590625 0.08273933809409607 0.032904654323033494 0.0011021881807063362 0.005664284839989426 1.117170681853062e-07 6.951880470103602 -0.12010896453893982 EKEFNK(ub)GPWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKEFNKGPWK 10 2 Q16531;F5GY55;F5H2L3 Q16531 DDB1 DNA damage-binding protein 1 1 81853800.0 19732500.0 32352300.0 29769000.0 True False 29935645.1389838 26578779.29532639 23885144.10178378 1.0 0.8878639218205483 0.7978830585040328 24.83536102611029 -6.973619469763982 0.1480790891665416 1.1074570992409776 0.575927163130546 0.9999986201692648 9.694808458379302e-05 0.07514484930652421 0.004517920888761643 0.004681507906476956 0.011314234797261045 1.0626262259632289e-07 6.973619469763982 -0.5315299361104315 EKEFNK(ub)GPWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKEFNKGPWK 10 2 Q16531;F5GY55;F5H2L3 Q16531 DDB1 DNA damage-binding protein 1 1 15096300.0 1361300.0 6332700.0 7402300.0 True False 1864609.3977492512 6052900.374561526 5654029.195153923 1.0 3.246202867940016 3.0322861195373343 20.830442012700313 -9.885559850440334 6.263140778725107 0.9999997762275115 3.139244493739054 0.9925563631925746 0.08733114683833727 2.732741206617671e-07 4.868533728548818e-08 0.08455802688608707 0.028186006442307145 1.3014879442139793e-10 9.885559850440334 2.1392447175115423 EKEFNK(ub)GPWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKEFNKGPWK 10 2 Q16531;F5GY55;F5H2L3 Q16531 DDB1 DNA damage-binding protein 1 1 30624600.0 7448200.0 15854500.0 7321900.0 True False 6193508.311206463 15769088.661628144 8852875.437359415 1.0 2.5460672480402966 1.4293797622489863 22.56232542454526 -10.263010618054034 6.004676441065421 0.9999629150266408 1.9877235051446296 0.5105593605862107 0.4558857570567022 0.00022636829505854627 2.7783577245240453e-05 0.4414259443725293 0.14713649540447926 5.457445180352084e-11 10.263010618054034 0.9877605901179888 EKEFNK(ub)GPWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKEFNKGPWK 10 2 Q16531;F5GY55;F5H2L3 Q16531 DDB1 DNA damage-binding protein 1 1 79847000.0 19732500.0 38300600.0 21813900.0 True False 25544110.235725947 36169137.94106679 17843994.029515345 1.0 1.4159482404081039 0.6985561002065661 24.60648734820274 -6.749532788718475 1.6518477644243874 1.244720851787501 0.6972041710546734 0.6468620925187412 0.17477905418430814 0.3008529059988784 1.6150402600496092 0.0835941141268518 0.20302176190866544 1.7801935012812752e-07 6.749532788718475 -0.5475166807328277 EKENLSYDLVPLK(ub)NGGVGIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKENLSYDLVPLKNGGVGIK 20 2 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;R4GN69 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 18063100.0 5642100.0 8340400.0 4080600.0 True False 7396847.738174123 7096044.830624569 3658378.6558791576 1.0 0.9593336353272286 0.49458617851476977 22.81847914798363 -6.924111718663317 0.7936476274012272 1.0088164854878652 0.4120669765044446 0.9952485951548357 0.01580375468298524 0.09581299215037778 0.09352159666253795 0.013921860365151074 0.043492403896944185 1.1909356102846863e-07 6.924111718663317 -0.5967495089834205 down EKENLSYDLVPLK(ub)NGGVGIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKENLSYDLVPLKNGGVGIK 20 2 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;R4GN69 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 20966000.0 6469000.0 7281600.0 7215400.0 True False 6263645.135951579 10189180.853042373 5325470.282639866 1.0 1.6267174515617613 0.8502190285450798 22.578571049018098 -6.691938768045818 1.859601341622045 1.392201055323998 0.8528452158021331 0.3794591547777414 0.26495475232654503 0.41252746668317397 2.7673688937796457 0.11391989686080194 0.2959242618102283 2.032643576780015e-07 6.691938768045818 -0.5393558395218649 EKENLSYDLVPLK(ub)NGGVGIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKENLSYDLVPLKNGGVGIK 20 2 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;R4GN69 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 91439000.0 18295000.0 28688000.0 44456000.0 True False 27754852.543656867 23568402.259632923 35669252.11424304 1.0 0.8491633029777806 1.285153724313154 24.726236692562335 -6.813284612820235 1.400698754810559 0.9181081190484897 1.2933664165679974 0.8682218722282716 0.0656275687290096 0.20235899251247383 0.7818459633626139 0.03683460866874859 0.08508569031264601 1.5371469482146857e-07 6.813284612820235 0.3752582975195078 EKENLSYDLVPLK(ub)NGGVGIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKENLSYDLVPLKNGGVGIK 20 2 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;R4GN69 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 15688500.0 5642100.0 5961100.0 4085300.0 True False 7728136.84201943 5697718.891278394 3120436.279394554 1.0 0.7372694101764287 0.4037760126642836 22.881689209506522 -6.96788324597227 0.3045334083870779 1.0548095677844092 0.07571825218182995 0.9999608444653064 0.0015266676190931 0.07699570943357155 0.011475734365128406 0.005412134492701025 0.029769038440681905 1.0767546452252979e-07 6.96788324597227 -0.9790913156025792 down EKENLSYDLVPLK(ub)NGGVGIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKENLSYDLVPLKNGGVGIK 20 2 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;R4GN69 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 17978200.0 6469000.0 7594700.0 3914500.0 True False 5379260.125291303 7553785.843670079 4733003.851396975 1.0 1.4042425292197631 0.8798614941754037 22.358976324452374 -6.700765192128494 1.8277136918395085 1.2508169300429168 0.8813743595599717 0.4214696520008059 0.17061019496861743 0.39389856532610396 2.558597420293196 0.07444791701900791 0.19131011383018412 1.9917499176043484e-07 6.700765192128494 -0.36944257048294515 EKENLSYDLVPLK(ub)NGGVGIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKENLSYDLVPLKNGGVGIK 20 2 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;R4GN69 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 101403000.0 18295000.0 19857000.0 63251000.0 True False 23683238.14836471 18751940.494294137 51739967.01006578 1.0 0.791781105979755 2.1846660784280605 24.497363014654784 -6.868852742229266 1.1402154803652857 0.8830289120327746 2.264457617641528 0.9635211572935429 0.1171659913551579 0.13795601607992583 0.33594001869186574 0.07980554297996754 0.1885663988847226 1.3525310929683192e-07 6.868852742229266 1.3814287056087533 up EKEPEK(ub)LDKLENSAAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKEPEKLDKLENSAAPK 17 3 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 10960500.0 2240500.0 3067600.0 5652400.0 True False 2169376.5538876937 4292508.677322673 4171866.871634771 1.0 1.978683078154486 1.923071798742573 21.048849062756496 -10.432393863057081 5.9884510084765585 0.9996206474581883 1.9508774384485297 0.9974412649963519 0.0227032097504228 0.00011502910925521207 1.0902853317391389e-05 0.02199045110532902 0.007327429439069949 3.6949293346008356e-11 10.432393863057081 0.9512567909903413 EKEPEK(ub)LDKLENSAAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKEPEKLDKLENSAAPK 17 3 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 20209800.0 4059900.0 8770700.0 7379200.0 True False 6159165.118447243 7205500.059208125 5920697.885581751 1.0 1.1698825929551744 0.9612825393897524 22.554303374610186 -6.690142983600878 1.8656620848245145 1.1064923949469052 0.9619983467505009 0.37111914432792237 0.07184658848039972 0.4164101851055153 2.8101762862344075 0.030804329577536843 0.08020943219369571 2.0410658500340954e-07 6.690142983600878 -0.14449404819640432 EKEPEK(ub)LDKLENSAAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKEPEKLDKLENSAAPK 17 3 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 9125700.0 2240500.0 4338600.0 2546600.0 True False 1863075.0209793085 4315227.1006553285 3079082.2858519657 1.0 2.3161853666993335 1.6526882982057662 20.829254338190772 -10.180542993034747 6.461892994936246 0.9999950117942529 1.9844368324525508 0.7458827551743403 0.27087154394028673 1.9465721654114407e-05 2.4685024878388815e-06 0.2622715719642917 0.0874234148868513 6.598679073268229e-11 10.180542993034747 0.9844418206582979 EKESVNAK(ub)VLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKESVNAKVLK 11 2 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 1889440.0 617090.0 543670.0 728680.0 True False 809010.9659080602 462556.55520906154 653283.1835921244 1.0 0.5717556061676778 0.8075084407030974 19.625799732535768 -10.104113720920754 5.242521796637892 1.0000062398415186 0.68963202343505 0.6979661288522357 0.09624569167227515 7.019499607576566e-06 1.1994183192681014e-06 0.09319136299515526 0.031063163415741248 7.868397270848593e-11 10.104113720920754 -0.31037421640646856 EKESVNAK(ub)VLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKESVNAKVLK 11 2 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 3203010.0 875310.0 1067200.0 1260500.0 True False 847523.7631704705 1493338.5253744777 930337.2358105641 1.0 1.7620019523560053 1.0977122721967107 19.692894294045757 -10.2389545532361 4.308740603199175 0.9997774408210386 1.4298571122874633 0.35827733585736843 0.2711951263448105 0.0005891601132127359 0.00010406170207183611 0.26272027057477504 0.0875278506522138 5.7682682230058146e-11 10.2389545532361 0.4300796714664247 EKESVNAK(ub)VLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKESVNAKVLK 11 2 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 10483000.0 1896300.0 2641500.0 5945200.0 True False 2876825.7380998335 2170103.6868662997 4770128.61412627 1.0 0.7543396383472537 1.6581221973065974 21.45604640270814 -6.834286558988465 1.3085765942424434 0.8690728233487756 1.6846556867485656 0.914195311433116 0.111768413651628 0.17557619265238605 0.5864516204616024 0.06702930965262767 0.15427250170846366 1.4645811526775523e-07 6.834286558988465 0.81558286339979 EKESVNAK(ub)VLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKESVNAKVLK 11 2 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 1845180.0 617090.0 518090.0 710000.0 True False 845244.8492302098 495199.07070547825 542312.622908999 1.0 0.5858646416555761 0.6416041735159931 19.68900979405866 -10.224149692724692 5.432375095671298 1.0000235600461473 0.613734407585971 0.9846225035826746 0.02275556859340172 6.493548192753388e-06 9.27429836721696e-07 0.022034326288566913 0.007344328182958231 5.968295357812688e-11 10.224149692724692 -0.38628915246017637 EKESVNAK(ub)VLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKESVNAKVLK 11 2 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 3028750.0 875310.0 1280700.0 872740.0 True False 727859.0478078108 1273800.6149009538 1055225.8989061676 1.0 1.7500649593316553 1.4497668224147666 19.473299569480034 -10.037713478663013 4.503751646834013 0.9999731956940449 1.5999158906521047 0.8418036024601331 0.12259620118998507 28270425.285145946 0.053295980826417955 8152.902082108304 0.04196794051064869 9.168251566470247e-11 10.037713478663013 0.5999426949580599 EKETLSLTLAEEK(ub)EVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKETLSLTLAEEKEVAR 17 2 H7BZ55 H7BZ55 Putative ciliary rootlet coiled-coil protein-like 3 protein 1 86345000.0 33240000.0 31599000.0 21506000.0 True False 50427510.16950824 25959911.565886162 17255329.673585344 1.0 0.5147966155502005 0.3421808773739347 25.58770765899359 -13.999999999999998 0.1439524568956323 3.327094761024685 0.13840037077816686 0.9995876572911719 0.0056548114442682195 11.94012810772842 0.11914586879601066 7.7894774214809175 0.1827041422343816 1.0000000000000041e-14 13.999999999999998 -3.188694390246518 EKETLSLTLAEEK(ub)EVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKETLSLTLAEEKEVAR 17 2 H7BZ55 H7BZ55 Putative ciliary rootlet coiled-coil protein-like 3 protein 1 85947000.0 33240000.0 40142000.0 12565000.0 True False 43029835.25835704 37908062.412346005 10278298.927787328 1.0 0.8809715906356785 0.23886447312835407 25.35883398108604 -6.938125875791561 0.6767725005805846 1.0074944927067189 0.07485462690073413 0.9979080051437661 0.015290232976275249 0.08863208224590866 0.05858138857973245 0.014680494421404384 0.05573659977556819 1.1531189896948377e-07 6.938125875791561 -0.9326398658059847 down EKFQDHVK(ub)TCGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKFQDHVKTCGK 12 2 Q12933-3;Q12933;Q12933-2 Q12933-3 TRAF2 TNF receptor-associated factor 2 1 5517430.0 347430.0 1387700.0 3782300.0 True False 449754.98386916344 1310473.2751136622 3093960.2096752897 1.0 2.913749312658839 6.879212728358208 18.778779742936333 -6.959346316758902 0.4445504903623076 0.8647544431737586 9.083989282753576 0.9997451818740261 0.03908405365261895 0.07993545615392329 0.02200037251882403 0.052592655083787646 0.3282944374663876 1.0981298153403276e-07 6.959346316758902 8.219234839579817 EKFYEAK(ub)LQQQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKFYEAKLQQQQR 13 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 18708800.0 8203900.0 9004800.0 1500100.0 True False 10755392.3466806 7661318.940435481 1344884.0419752775 1.0 0.7123235204711028 0.12504276911760867 23.35855681810185 -7.293321942704485 0.56906799503257 1.003727346122364 3.6902595077521947e-22 0.997480505367936 0.018276509843148197 0.09875776300130414 0.06063698695110501 0.018074976550962702 0.05847121801790068 5.08953443752806e-08 7.293321942704485 -1.003727346122364 down EKFYEAK(ub)LQQQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKFYEAKLQQQQR 13 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 23554700.0 9390300.0 8963400.0 5201000.0 True False 9092210.066490354 12542532.363513501 3838702.073344499 1.0 1.379481146145031 0.42219680861666015 23.116199585902162 -6.799141330194463 1.4593579599546187 1.209604704636543 0.40925054432508456 0.8296613910758958 0.162445063633387 0.22198228473221646 0.9334255340804777 0.08757204379672681 0.20377299651808367 1.5880298801969347e-07 6.799141330194463 -0.8003541603114585 down EKFYEAK(ub)LQQQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKFYEAKLQQQQR 13 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 76089000.0 43254000.0 18253000.0 14582000.0 True False 65619480.29097194 14995609.538660085 11699861.308482366 1.0 0.22852374740193135 0.17829859755978678 25.96762083190806 -13.651048678979574 0.391415828909369 9.999998485857578 0.17468180438422357 0.9998180164675255 0.005073295748873504 19.249103766860095 0.2047313559967528 145.0588162714975 0.013169922789383783 2.233321881350625e-14 13.651048678979574 -9.825316681473355 EKFYEAK(ub)LQQQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKFYEAKLQQQQR 13 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 18443900.0 8203900.0 7071900.0 3168100.0 True False 11237103.532061314 6759440.074354003 2419860.0290676043 1.0 0.6015286817522152 0.21534553118277708 23.42176687962474 -7.644082652717976 0.34354654680622226 1.0689971912140446 1.0252616290768824e-10 0.9992096026442479 0.009006234047179743 0.12352793504942815 0.04724671788366158 0.027953721587395758 0.07394616415030514 2.26943290384889e-08 7.644082652717976 -1.0689971911115184 down EKFYEAK(ub)LQQQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKFYEAKLQQQQR 13 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 25775700.0 9390300.0 13620000.0 2765400.0 True False 7808450.51082438 13546626.356641656 3343632.3542350736 1.0 1.7348674154831092 0.4282068957983404 22.89660486133644 -6.754093485507859 1.6344389560000476 1.4299795554615458 0.42474006648760354 0.6664468400012244 0.30888310809847025 0.29298451190138103 1.541039935398158 0.14920548985561793 0.36072419428930186 1.7615968071970506e-07 6.754093485507859 -1.0052394889739422 EKFYEAK(ub)LQQQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKFYEAKLQQQQR 13 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 80033800.0 43254000.0 30882000.0 5897800.0 True False 55993155.66380788 29163389.552540228 4824460.9165383335 1.0 0.5208384704666766 0.08616161849325284 25.73874715400051 -7.9200062015234725 0.45594613392255035 1.0367248913144307 1.5068848113005939e-19 0.9960417686136583 0.02348095725137862 0.1045036562703665 0.10012062541870732 0.03911236933563456 0.07915238158226735 1.2022472669623099e-08 7.9200062015234725 -1.0367248913144307 down EKIEDAK(ub)ESQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKIEDAKESQR 11 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 109002000.0 33480000.0 45477000.0 30045000.0 True False 43892604.220781215 38692008.86795761 26936231.611990675 1.0 0.8815154524287407 0.613684972450041 25.387474534430666 -6.957582383353178 0.4682695575075105 1.0071944125053776 0.47705832438650053 0.9996697361168929 0.0029366527343817348 0.080576407327753 0.024410578724854897 0.0036912645459505605 0.022108359587895886 1.1025990568340063e-07 6.957582383353178 -0.530136088118877 EKIEDAK(ub)ESQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKIEDAKESQR 11 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 119887000.0 41402000.0 48986000.0 29499000.0 True False 40087716.17230904 68546365.25861529 21772326.948969312 1.0 1.7099094636367516 0.5431171697431032 25.256656892607236 -6.742012968372054 1.6792420122670888 1.4214040995108383 0.5421173151111869 0.6139786542259509 0.2982641775369904 0.3141874026730207 1.7403288854676677 0.14046791952430082 0.3439481989376681 1.8112860053988256e-07 6.742012968372054 -0.8792867843996515 EKIEDAK(ub)ESQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKIEDAKESQR 11 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 108221000.0 37199000.0 27439000.0 43583000.0 True False 56433602.611177415 22542296.068114467 34968800.94689248 1.0 0.3994481129164997 0.6196450222720045 25.75005111557261 -10.159608917191811 5.314245038409053 1.0000167707944512 0.5095465675940711 0.8686755095590448 0.08989501181047913 1.7862778069464804e-05 2.824720013732447e-06 0.08704344383650975 0.02901349030399562 6.924542462955049e-11 10.159608917191811 -0.49047020320038004 EKIEDAK(ub)ESQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKIEDAKESQR 11 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 113648000.0 33480000.0 46349000.0 33819000.0 True False 45858460.76298021 44301147.924353264 25831648.724168204 1.0 0.9660408829097878 0.5632907928959777 25.450684595953557 -6.92356480617705 0.79784998170342 1.0077975686225003 0.4927039516161654 0.9951150081121823 0.013863048624709754 0.09611968353638659 0.09507886365576775 0.012175694007173008 0.0378130152407027 1.1924363151606352e-07 6.92356480617705 -0.5150936170063348 EKIEDAK(ub)ESQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKIEDAKESQR 11 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 109075000.0 41402000.0 50078000.0 17595000.0 True False 34427597.41958734 49808219.8742953 21274033.149911784 1.0 1.4467527102532363 0.6179354571460184 25.037062168041512 -6.760318137388032 1.6114453584217987 1.2593982654317786 0.6148775309447728 0.6922023899895435 0.18791275410223865 0.28238147924628065 1.4453173366716532 0.0920073309281258 0.22102344544404617 1.7365282890472482e-07 6.760318137388032 -0.6445207344870058 EKIEDAK(ub)ESQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKIEDAKESQR 11 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 95992000.0 37199000.0 28829000.0 29964000.0 True False 48154838.80191407 27224640.807272267 24510859.45660327 1.0 0.5653562857776638 0.5090009657685534 25.52117743766506 -13.999999999999998 0.2879839624391659 4.703099683545787 0.4933296113217843 0.9996229521525211 0.0042599679580460955 15.846896697166464 0.17013639496310856 34.72510066863305 0.02147951725851672 1.0000000000000041e-14 13.999999999999998 -4.209770072224003 EKLEATINELV ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKLEATINELV 11 1 P10599;P10599-2 P10599 TXN Thioredoxin 0 84321000.0 11062000.0 38045000.0 35214000.0 False True 14502389.124560375 32368834.298248485 31570393.076539837 1.0 2.231965645124676 2.1769098046799833 23.789787253708884 -10.079221646611199 4.951010194963986 0.999966733942419 2.204437724909544 0.9984353423339344 0.02247645276657021 8.253467672512496e-06 1.534940442523061e-06 0.021763329813848716 0.007254243933661198 8.332558154927714e-11 10.079221646611199 1.204470990967125 EKLEATINELV ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKLEATINELV 11 1 P10599;P10599-2 P10599 TXN Thioredoxin 0 72401000.0 23341000.0 11910000.0 37150000.0 False True 22600052.73121746 16665725.10982949 27419300.523889296 1.0 0.737419744459672 1.2132405552317587 24.429822803001432 -6.756915984218733 1.6242419650016788 0.8468918163127727 1.2147082755970917 0.6781640840546144 0.11039819070220695 0.288142123198249 1.497502992462863 0.053648595636332924 0.12931334128498484 1.7501852353111608e-07 6.756915984218733 0.36781645928431905 EKLEATINELV ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKLEATINELV 11 1 P10599;P10599-2 P10599 TXN Thioredoxin 0 45707600.0 23341000.0 9624600.0 12742000.0 False True 19409075.681623787 9572750.36946649 15406293.287648551 1.0 0.49321000785884006 0.7937674900322529 24.21022807843571 -10.292244730070651 5.850651179594512 1.0000257776922985 0.6434887489455474 0.6522934408825375 0.12270207828342444 4.1260343153703e-05 4.991325216881976e-06 0.11881435203947087 0.039601925478060976 5.1021740541666136e-11 10.292244730070651 -0.3565370287467511 EKLEATINELV ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKLEATINELV 11 1 P10599;P10599-2 P10599 TXN Thioredoxin 0 44842000.0 8404000.0 23772000.0 12666000.0 False True 10879143.66760629 22449067.30273255 10360917.96413484 1.0 2.0634958034037947 0.9523652118857003 23.37506166610138 -6.656069604315889 1.9865228965537558 1.6867369370021412 0.956984121312742 0.21922395825888652 0.45323557657193386 0.49378482460301876 3.7415357597360317 0.18458600008367024 0.5023444010417447 2.207650884765436e-07 6.656069604315889 -0.7297528156893992 EKLEAYQHLFYLLQTNPTYLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKLEAYQHLFYLLQTNPTYLAK 22 1 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 15379000.0 6693500.0 2228800.0 6456700.0 False True 6481018.506336668 3118771.463038457 4765496.573151985 1.0 0.4812162563629698 0.7353005655658335 22.62778912295502 -10.120386214624327 5.215813653899096 1.0000101180767949 0.6082584109640041 0.7601595828404858 0.10372948486715508 1.220498527531208e-05 2.058302308404733e-06 0.10043823398997215 0.033478547283229736 7.579032779004844e-11 10.120386214624327 -0.3917517071127907 EKLEAYQHLFYLLQTNPTYLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKLEAYQHLFYLLQTNPTYLAK 22 1 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 13845800.0 6693500.0 2281500.0 4870800.0 False True 5565941.822327616 2269209.106657708 5889261.759965355 1.0 0.4076954411479547 1.0580889897808041 22.408194398389295 -6.667036802194085 1.948035114585714 0.6209766236881427 1.0554214932616464 0.2659689916672885 0.2517707994845915 0.4679262096604267 3.42052904316939 0.10415860830627156 0.279349384078436 2.1525993153343954e-07 6.667036802194085 0.4344448695735037 EKLEMEMEAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKLEMEMEAAR 11 1 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 29164400.0 6429200.0 13286500.0 9448700.0 False True 8428743.460461358 11304205.99037137 8471039.162330393 1.0 1.341149608289611 1.005018031699202 23.006886142546236 -10.481468727315036 8.27718930040674 0.9999911636094314 1.1730838199944065 0.2611941206086619 0.13722514151395757 2.2377678290234065e-05 1.4018401695405254e-06 0.13287445160097514 0.04428922398037614 3.300131706496742e-11 10.481468727315036 0.17309265638497506 EKLEMEMEAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKLEMEMEAAR 11 1 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 17301950.0 4501700.0 2396050.0 10404200.0 False True 4358795.997605998 3352805.260235683 7679027.900690421 1.0 0.769204445924324 1.761731428795477 22.055498252913 -6.84546387947599 1.2567207331294694 0.8771614654568265 1.7980823880376635 0.9334511298158492 0.10940076390783557 0.16251613125015457 0.4961976032995963 0.06818981183897604 0.1574101170119132 1.4273685402977942e-07 6.84546387947599 0.920920922580837 EKLEMEMEAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKLEMEMEAAR 11 1 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 20112900.0 6429200.0 6810400.0 6873300.0 False True 8806248.982597131 6509494.009018878 5249968.1000569295 1.0 0.7391903206328723 0.5961639411322451 23.070096204069127 -13.999999999999437 0.07252918979070294 2.479677251202933 0.1030638027411415 0.9999155803835146 0.001536100778322472 12.334206767341762 0.07353066139338882 3.042232064691907 0.4524238646908715 1.0000000000012966e-14 13.999999999999437 -2.376613448461791 EKLEMEMEAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKLEMEMEAAR 11 1 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 9082080.0 4501700.0 2338600.0 2241780.0 False True 3743363.009124106 2326001.4976242455 2710525.833180407 1.0 0.6213668009099916 0.7240884270571002 21.835903528347277 -10.135610935034041 7.515411308120106 1.000000104392671 0.6727276139835474 0.9311969246081926 0.04193592826822512 7.333604971770491e-08 8.45334955088327e-09 0.04060430065358672 0.013534762649215402 7.317943717044215e-11 10.135610935034041 -0.32727249040912354 EKLEQAAIVK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKLEQAAIVKEK 12 2 Q13451 Q13451 FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5;Peptidyl-prolyl cis-trans isomerase FKBP5, N-terminally processed 1 5669900.0 1027000.0 1624600.0 3018300.0 True False 1329471.7451965322 1534189.5818618243 2469000.3703733026 1.0 1.1539843455906083 1.8571288779125703 20.34242168574653 -6.941848327944638 0.642145640360934 0.9922901196271716 2.057515014899989 0.9983960277519874 0.014942279414372824 0.08693358664028451 0.0508465285324645 0.014757536267106599 0.0600426954922615 1.1432775408256034e-07 6.941848327944638 1.0652248952728172 EKLESAEPPEK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKLESAEPPEKK 12 2 Q99856 Q99856 ARID3A AT-rich interactive domain-containing protein 3A 1 2689970.0 802680.0 803090.0 1084200.0 True False 1052321.2531641775 683272.1024203012 972017.3843807727 1.0 0.6492999170793149 0.9236888273975815 20.005143767866365 -9.840588181970235 6.001571692203763 1.0000000235026145 0.786494372238228 0.44668235625428787 0.11201880356045783 3.514709909987132e-08 7.001726102807676e-09 0.10846175147601943 0.03615391338752973 1.443483480278606e-10 9.840588181970235 -0.21350565126438648 EKLESAEPPEK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKLESAEPPEKK 12 2 Q99856 Q99856 ARID3A AT-rich interactive domain-containing protein 3A 1 3663300.0 1292700.0 1194400.0 1176200.0 True False 1251663.9460882046 1671330.148713715 868117.9347563544 1.0 1.3352866429819945 0.6935710958755844 20.255415840548167 -6.764712619771274 1.5945716389351545 1.1936067645143462 0.6906510724683224 0.7099687093152168 0.14113531309199207 0.2750698248510598 1.3793996112609754 0.06979955271117504 0.16697896423615527 1.7190455332749028e-07 6.764712619771274 -0.5029556920460239 EKLESAEPPEK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKLESAEPPEKK 12 2 Q99856 Q99856 ARID3A AT-rich interactive domain-containing protein 3A 1 3427380.0 802680.0 1301100.0 1323600.0 True False 1099452.4876113783 1243613.0998376666 1010992.9403976774 1.0 1.1311203656826365 0.9195421828496798 20.068353829389256 -6.7391058113873905 1.6902508096098723 1.0780974663825762 0.9194488079179498 0.6008211496964009 0.05509218807553762 0.3194263358667404 1.7915716398697525 0.025790389024377892 0.06334264686834264 1.8234513830045588e-07 6.7391058113873905 -0.1586486584646264 EKLILPHVDIQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKLILPHVDIQLK 13 1 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 25240000.0 4448100.0 12773000.0 8018900.0 False True 6748092.899668768 10493558.354095502 6433960.900191269 1.0 1.5550405885210294 0.9534487737279197 22.686048404385467 -6.664219783241203 1.9578027991834932 1.356028581365759 0.9559315045861282 0.25367857336755384 0.23608844506334833 0.4745617701526824 3.5009932418653666 0.09727427134782468 0.2618730371007675 2.1666073731728757e-07 6.664219783241203 -0.4000970767796309 EKLILPHVDIQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKLILPHVDIQLK 13 1 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 15677500.0 4448100.0 6215400.0 5014000.0 False True 5758153.135159392 5869507.526224302 4101503.4479845357 1.0 1.0193385602034406 0.712294958420032 22.457174726477916 -6.89188589007362 1.0111240233356735 1.015759631539465 0.6848859371865775 0.982079386895686 0.018795819765322686 0.11762774769740744 0.21299935822144622 0.014127254811473457 0.03546845187131844 1.2826675564829216e-07 6.89188589007362 -0.3308736943528875 EKLPSSEVVK(ub)FGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKLPSSEVVKFGR 13 2 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 1 87280200.0 6704200.0 17686000.0 62890000.0 True False 10170761.542671995 14529795.118651295 50459763.93433381 1.0 1.428584777815381 4.961257200124796 23.277924370221434 -6.929544151837841 0.7505258328156856 0.9453600262597721 5.678145546098717 0.9964478602382889 0.10578856609249865 0.0928752814204481 0.07884523467613139 0.09611832088269832 0.3204511410505705 1.1761314091314638e-07 6.929544151837841 4.732785519838945 up EKLPSSEVVK(ub)FGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKLPSSEVVKFGR 13 2 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 1 84222200.0 6704200.0 16933000.0 60585000.0 True False 8678719.059539028 15990663.664696708 49559151.65459571 1.0 1.8425142644894024 5.710422392360291 23.049050692313884 -6.941725801700235 0.6433071631626581 0.9575462758592131 6.808656433792293 0.9983813307056082 0.08251638878982712 0.08698804681535419 0.05108983879179753 0.08141564133684878 0.3304543152429406 1.1436001359113767e-07 6.941725801700235 5.851110157933079 EKNPDMVAGEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKNPDMVAGEKR 12 2 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 7150300.0 2486600.0 2789200.0 1874500.0 True False 3259956.6802686574 2373062.232216444 1680544.7214736736 1.0 0.7279428731613933 0.5155113660391272 21.63642136274469 -7.13942664233535 0.14605557378548847 1.2729535312248175 6.471856601701223e-13 0.9999979697391201 0.00028247937707602126 0.08189570531955408 0.005562560291778776 0.014913708267953686 0.03191857699434956 7.253929955175545e-08 7.13942664233535 -1.2729535312241702 EKNPDMVAGEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKNPDMVAGEKR 12 2 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 11103500.0 4015900.0 4299600.0 2788000.0 True False 3888417.452692523 6016452.702117788 2057739.1617928226 1.0 1.5472754083931273 0.5291970800017748 21.890751681426202 -6.760742587638438 1.6101803658775358 1.3176031351844613 0.5254050760544616 0.6937981210242359 0.23020645935294468 0.28167154107236236 1.43957032924425 0.11280662763450613 0.27083897562721043 1.7348319520366588e-07 6.760742587638438 -0.7921980591299996 EKNPDMVAGEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKNPDMVAGEKR 12 2 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 7807300.0 2641800.0 2789100.0 2376400.0 True False 4007803.74145027 2291363.3136622347 1906703.4983868808 1.0 0.5717254290583297 0.47574772154310085 21.934380432106572 -13.999999999999998 0.21016116896139375 3.478506244817358 0.41930515041896943 0.9994901023701507 0.005146327685382482 12.750463070352096 0.14530299291377288 13.050137493758148 0.05678831926986909 1.0000000000000041e-14 13.999999999999998 -3.0592010943983885 EKNPDMVAGEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKNPDMVAGEKR 12 2 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 6572200.0 2486600.0 2818400.0 1267200.0 True False 3405963.217838311 2693873.7687975406 967913.4588032168 1.0 0.7909286144632185 0.28418200576385844 21.699631424267583 -6.956121503837776 0.4870268928563094 1.011394467338548 0.04233578027317058 0.9995982175502577 0.006024099737553867 0.08111680258830703 0.026480246631376814 0.007249900213833739 0.04179561719843801 1.1063142239093604e-07 6.956121503837776 -0.9690586870653775 down EKNPDMVAGEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKNPDMVAGEKR 12 2 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 10315080.0 4015900.0 5361100.0 938080.0 True False 3339398.784535065 5332218.690204962 1134228.1908081407 1.0 1.5967600859468336 0.3396504173328482 21.67115695686048 -6.77759020057638 1.5450504895393091 1.3389487438757999 0.33039251982821655 0.7588702844405815 0.25212042838560955 0.2543197109910327 1.1989457658862117 0.12854120815840916 0.3039463747830483 1.6688211662326203e-07 6.77759020057638 -1.0085562240475834 EKNPDMVAGEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKNPDMVAGEKR 12 2 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 7621200.0 2641800.0 3885900.0 1093500.0 True False 3419862.177663289 3669646.2490193727 894494.2202574967 1.0 1.073039221576688 0.2615585581488794 21.70550675419902 -6.884925532336496 1.0519142073065257 1.0490517817202594 0.19832114256080616 0.9774474106251595 0.05504446962339377 0.12335791631753774 0.24666189448607165 0.04011262825670922 0.0983406212469602 1.3033902491838551e-07 6.884925532336496 -0.8507306391594532 down EKPQTLPSAVK(ub)GDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKPQTLPSAVKGDEK 15 2 Q12972 Q12972 PPP1R8 Nuclear inhibitor of protein phosphatase 1;Activator of RNA decay 1 1663090.0 1102000.0 0.0 561090.0 True False 1509439.1804302305 0.0 428572.0980112816 1.0 0.0 0.2839280333833173 20.525581197087007 -10.215048267016167 5.344831777464996 1.000054710481244 0.14196401669158998 0.924109042756328 0.11591313424401337 7.557301161416863e-05 1.1098534120228246e-05 0.11223951307545048 0.037410803211074053 6.094691577369585e-11 10.215048267016167 -0.8580906937896541 EKPQTLPSAVK(ub)GDEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKPQTLPSAVKGDEK 15 2 Q12972 Q12972 PPP1R8 Nuclear inhibitor of protein phosphatase 1;Activator of RNA decay 1 9538600.0 1542800.0 3011100.0 4984700.0 True False 1997185.0131345752 2843529.6380303754 4077535.747341153 1.0 1.423768764200501 2.041641470632445 20.929536555169733 -6.965724396093339 0.34539364397120353 0.9370348295523431 2.5490781607097355 0.9999273089017422 0.003646545979911018 0.07771598596316494 0.013997938686391532 0.008585881419424084 0.0532741723987415 1.0821204486513866e-07 6.965724396093339 1.6120433311573925 up EKPSYDTETDPSEGLMNVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKPSYDTETDPSEGLMNVLK 20 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 28334600.0 9138000.0 2340600.0 16856000.0 False True 8847919.191888308 3275213.786067756 12440907.93083924 1.0 0.37016768745700596 1.406082906164531 23.07690677881244 -6.742117713166995 1.6787637907763515 0.6261752635085592 1.4069972482596622 0.6144786203798575 0.2646206053531178 0.31400120081523647 1.7383285530440327 0.12465436060825623 0.3052036055284519 1.8108492052276805e-07 6.742117713166995 0.780821984751103 EKPSYDTETDPSEGLMNVLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKPSYDTETDPSEGLMNVLKK 21 2 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 30267900.0 9729800.0 9465400.0 11072700.0 True False 9420932.824823251 13244983.581408905 8172427.696120294 1.0 1.4059099908354773 0.8674754239396266 23.167438486393362 -6.705031977127656 1.8128277178133512 1.250802189456076 0.8689129861205207 0.4414957009036794 0.1711875693958293 0.38516453724668287 2.464167717755812 0.07523624806545035 0.1923019345189679 1.9722775118619634e-07 6.705031977127656 -0.3818892033355552 EKPSYDTETDPSEGLMNVLK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKPSYDTETDPSEGLMNVLKK 21 2 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 29081000.0 6389900.0 12747000.0 9944100.0 True False 9693945.46426415 10472198.257234415 7978644.276346131 1.0 1.080282357254765 0.8230543802581394 23.208652535606394 -6.822837480150334 1.3594775956473764 1.0431525549658531 0.8170862221567433 0.8907985263878875 0.03550954868650549 0.18982132069810131 0.6885499207908042 0.020521171805429332 0.04726778966513918 1.5037045707992723e-07 6.822837480150334 -0.22606633280910982 EKPSYDTETDPSEGLMNVLK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKPSYDTETDPSEGLMNVLKK 21 2 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 14532400.0 8659100.0 3475300.0 2398000.0 True False 11860603.273378782 3321749.754719737 1831641.7883602518 1.0 0.2800658346085507 0.15443074404751286 23.49967405667363 -13.999999999999998 0.2455830343631334 5.897479085041758 0.10174907404577736 0.9995345859498384 0.008036980963263983 13.827201646944228 0.15682386790876537 33.3189878835927 0.059439067414751676 1.0000000000000041e-14 13.999999999999998 -5.795730010995981 EKPSYDTETDPSEGLMNVLK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKPSYDTETDPSEGLMNVLKK 21 2 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 28921900.0 9729800.0 14158600.0 5033500.0 True False 8090759.8032244975 14082324.81153794 6085981.577725544 1.0 1.7405441706384066 0.752213849594204 22.947843761827638 -6.706171293177582 1.8088947978524836 1.4570366999679323 0.7547891203217303 0.44691632995547703 0.3122539582304728 0.3828057054657585 2.4392305679659123 0.13749845985998813 0.35093659751204287 1.9671102747162759e-07 6.706171293177582 -0.702247579646202 EKPSYDTETDPSEGLMNVLK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKPSYDTETDPSEGLMNVLKK 21 2 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 47059900.0 6389900.0 25656000.0 15014000.0 True False 8271851.513759789 24228221.04656344 12281606.056649359 1.0 2.9289961269567124 1.4847469198666774 22.979778857698843 -6.572340244083087 2.297753842911072 2.319605465223729 1.4879114369458397 0.0 0.8396377382674904 0.7225456927766769 7.164790292500125 0.3083791053389442 0.940272422828024 2.677070176626454e-07 6.572340244083087 -0.8316940282778893 EKPYFPIPEEYTFIQNVPLEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKPYFPIPEEYTFIQNVPLEDR 22 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 7780300.0 1791300.0 4943200.0 1045800.0 False True 2348411.646973874 4205693.8284426825 937590.648021962 1.0 1.790867386415015 0.39924459122408396 21.163253886202646 -6.752481781238148 1.640200741855563 1.4636173176957505 0.395860023994273 0.6598420803374826 0.33237846161889845 0.29569624982016673 1.5657943312043667 0.16001708501446643 0.3875415032747997 1.7681463903606724e-07 6.752481781238148 -1.0677572937014776 EKPYFPIPEEYTFIQNVPLEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKPYFPIPEEYTFIQNVPLEDR 22 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 48212100.0 17979000.0 6720100.0 23513000.0 False True 17408266.48620705 9403470.97485855 17354239.925120015 1.0 0.5401727381821232 0.996896499652631 24.05326921089558 -10.941600151285517 10.150359047264978 1.059116213995238 0.7685346189173777 0.25509611854790826 0.18645669483455998 0.10789253730904157 0.0006207564868534826 0.07808852314654105 0.06017863949026074 1.1439310510534002e-11 10.941600151285517 -0.2905815950778602 EKPYFPIPEEYTFIQNVPLEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKPYFPIPEEYTFIQNVPLEDR 22 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 8077400.0 1791300.0 2675600.0 3610500.0 False True 2453592.0180623163 2557383.1449739975 2757774.2605816047 1.0 1.0423017054781782 1.1239742550024723 21.226463947725538 -6.960728799388815 0.4250421405384941 0.9965799884895802 1.1728024694101264 0.9997962586085405 0.0007344496419968489 0.07944185171795826 0.020177308649130397 0.0010603462073425632 0.006789520588454006 1.0946397143229427e-07 6.960728799388815 0.17622248092054627 EKPYFPIPEEYTFIQNVPLEDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKPYFPIPEEYTFIQNVPLEDR 22 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 25362800.0 17979000.0 4195600.0 3188200.0 False True 14950335.104747614 4172997.4700386045 3854837.879428742 1.0 0.2791240089804697 0.257842908029841 23.833674486329855 EKQEEEEAK(ub)CLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKQEEEEAKCLEK 13 2 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 6392100.0 2742300.0 2509500.0 1140300.0 True False 3595181.856470972 2135092.3819543854 1022312.6945299703 1.0 0.5938760449937825 0.2843563233637009 21.777633318234393 -7.908718808354247 0.2500387203219399 1.1679635804013717 7.198204884686058e-10 0.999661057002846 0.005395097129990843 0.11155121121130758 0.041863332345122864 0.05850721821535959 0.0916340130859347 1.23390348729246e-08 7.908718808354247 -1.1679635796815513 down EKQEEEEAK(ub)CLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKQEEEEAKCLEK 13 2 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 3247470.0 1284600.0 1236100.0 726770.0 True False 1243821.0761544884 1729681.176176344 536407.1343673497 1.0 1.3906189638818354 0.4312574731614577 20.246347537823294 -6.796167933054855 1.471483935776743 1.2165862877435587 0.419233384739671 0.8207004687781349 0.16679277706962498 0.22629139011660665 0.9676875932553464 0.08918830273552483 0.20792411277159384 1.5989396308470365e-07 6.796167933054855 -0.7973529030038877 down EKSDEEEQQYVIK(ub)CGTCTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EKSDEEEQQYVIKCGTCTK 19 2 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 15545600.0 1927600.0 1657000.0 11961000.0 True False 2495316.1986765633 1564786.4933799366 9784220.730223976 1.0 0.6270894623334108 3.9210344305916887 21.25079121028096 -6.878756079754137 1.0866647760767119 0.77244276082787 4.149021087513301 0.9726702701345465 0.2434747190573208 0.1287399438961401 0.2789659601069759 0.17277896198388132 0.41655164158413266 1.3220379445155494e-07 6.878756079754137 3.376578326685431 up EKVDLVLLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKVDLVLLGK 10 1 P38117-2;P38117 P38117-2 ETFB Electron transfer flavoprotein subunit beta 0 9077200.0 2861300.0 3814100.0 2401800.0 False True 3751192.008868611 3245051.147245356 2153284.7756924382 1.0 0.8650719930020562 0.5740268081723404 21.838917680138245 -6.958539838407729 0.45554552522457264 1.0088714904419034 0.41858194113647174 0.9997121517785533 0.0030157725222265605 0.08022689963880902 0.023090109529447983 0.003923689453777372 0.024055888596108528 1.1001709205319162e-07 6.958539838407729 -0.5902895493054316 EKVDLVLLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKVDLVLLGK 10 1 P38117-2;P38117 P38117-2 ETFB Electron transfer flavoprotein subunit beta 0 10376500.0 2861300.0 2623000.0 4892200.0 False True 3919199.9337250614 2507107.1868989314 3736763.118021692 1.0 0.6396987214979907 0.9534504953081152 21.902127741661136 -10.178922320552234 7.459966332032541 1.00000015247313 0.7965746084030529 0.35918031217143076 0.12808862528798798 3.2480709270861325e-07 3.567324246908578e-08 0.12402137054699579 0.041340426048248294 6.623349606823413e-11 10.178922320552234 -0.20342554407007696 EKVEVQLPELFHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKVEVQLPELFHK 13 1 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28;Q13303-5;A0A590UJJ4 Q13303-3 KCNAB2 Voltage-gated potassium channel subunit beta-2 0 10872100.0 2334700.0 5604000.0 2933400.0 False True 3060814.3092669626 4767905.044220907 2629879.9071597103 1.0 1.557724370859589 0.8592092304317352 21.545484092717096 -6.694027500496137 1.8519325658564902 1.3483243737339823 0.8614871525070056 0.3894247688346557 0.23568815768488066 0.4080649975279288 2.716402559291924 0.10169063840110981 0.2634898181493463 2.0228910806433473e-07 6.694027500496137 -0.4868372212269767 EKVEVQLPELFHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKVEVQLPELFHK 13 1 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28;Q13303-5;A0A590UJJ4 Q13303-3 KCNAB2 Voltage-gated potassium channel subunit beta-2 0 12498400.0 3281200.0 4410800.0 4806400.0 False True 3177040.1020380734 6172055.442018142 3547459.6510907523 1.0 1.942706180529092 1.1165926576800382 21.59925186984027 -10.20052480663554 4.400369542202698 0.9998696635010854 1.5296494188982732 0.3540345048597835 0.3372594339322464 0.0005318180312014306 9.66221367575352e-05 0.32664822671950594 0.10885001429056736 6.301953485893968e-11 10.20052480663554 0.5297797553971878 EKVEVQLPELFHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EKVEVQLPELFHK 13 1 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28;Q13303-5;A0A590UJJ4 Q13303-3 KCNAB2 Voltage-gated potassium channel subunit beta-2 0 17613900.0 4949700.0 8021300.0 4642900.0 False True 7509056.771540765 6589836.344297052 3725228.779944637 1.0 0.8775851008707849 0.49609809770825136 22.84020026847745 -6.950592387542464 0.5523036681390728 1.005205233087806 0.35048536198816227 0.9992469427290517 0.005888716999403293 0.08324877317250082 0.034984898312523285 0.006372721561573732 0.03166156570325932 1.1204890389487062e-07 6.950592387542464 -0.6547198710996438 down EKVEVQLPELFHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EKVEVQLPELFHK 13 1 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28;Q13303-5;A0A590UJJ4 Q13303-3 KCNAB2 Voltage-gated potassium channel subunit beta-2 0 12843700.0 2334700.0 2494300.0 8014700.0 False True 3197901.6828951575 2384093.57845292 6121792.927927816 1.0 0.745518097446488 1.9143155528113582 21.608694154239988 -6.8496716230971195 1.2366389261274071 0.864235283745195 1.9607539594870633 0.9398328373980348 0.12310258374489619 0.15781664457836375 0.4645893584507468 0.07790072688792428 0.18023340440687968 1.4136059904073375e-07 6.8496716230971195 1.0965186757418683 EKVEVQLPELFHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKVEVQLPELFHK 13 1 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28;Q13303-5;A0A590UJJ4 Q13303-3 KCNAB2 Voltage-gated potassium channel subunit beta-2 0 8268700.0 3281200.0 3629100.0 1358400.0 False True 2728463.181806431 3609549.3179800524 1642435.159468039 1.0 1.3229239602897194 0.6019634680870546 21.379657145274546 -6.784940206674376 1.5165359113938464 1.1816747566849473 0.59533325848292 0.7845090982060362 0.13687828458699966 0.24297289780590778 1.1039659300950853 0.07106626523859667 0.16701390300283553 1.6408156638701196e-07 6.784940206674376 -0.5863414982020273 EKYEK(ub)LVSSGFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EKYEKLVSSGFR 12 2 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 4807720.0 1214900.0 985420.0 2607400.0 True False 1592745.6651083373 838399.1771370748 2337611.259946896 1.0 0.5263860988628385 1.467661354324197 20.60308448026682 -6.769937620522658 1.5750115334563395 0.7283228666605818 1.4729031716875052 0.7302098757716493 0.1995983447447317 0.2665292942472763 1.3048807695309674 0.09989763752789045 0.23778052908215477 1.6984875956021605e-07 6.769937620522658 0.7445803050269234 EKYEK(ub)LVSSGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EKYEKLVSSGFR 12 2 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 7693600.0 1820300.0 3214800.0 2658500.0 True False 1513660.102963015 3197481.2343121623 3214380.0584848262 1.0 2.1124169343256383 2.123581147572446 20.529609849401883 -10.936287417390592 0.7801250794968576 5.192999967735513e-13 2.1212656446391875 0.9999871955951268 0.0018859452362088266 2.942403649826935 0.4124533429210218 5.3470396507420075 0.001632958289705889 1.158010727532141e-11 10.936287417390592 2.1212656446386684 EKYIDQEELNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EKYIDQEELNK 11 1 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 0 11220250.0 3443600.0 940950.0 6835700.0 False True 3334284.8029313367 1316676.2419894252 5045225.103395697 1.0 0.39489015480377354 1.51313562025661 21.668945908869873 -6.759745680815768 1.6134191343895963 0.6484036813953997 1.5171695117291 0.6899151160049843 0.25450183797471865 0.2833538331513166 1.453689576285985 0.12446150860498957 0.29917676280475014 1.738818768271262e-07 6.759745680815768 0.8687658303337003 ELADESQTLK(ub)EANLLNAVIVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELADESQTLKEANLLNAVIVQR 22 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 22139300.0 4862100.0 8194200.0 9083000.0 True False 4707755.296878986 11466186.79218848 6703889.815840823 1.0 2.4355953249715436 1.4240098291185987 22.16660790219966 -10.286763789594687 6.022267004957282 0.9999528967024466 1.929802577045055 0.5297344430644266 0.41297804934001037 0.00026121738984366316 3.0936769878654544e-05 0.39988436361813623 0.13328809228692282 5.166973217223518e-11 10.286763789594687 0.9298496803426085 ELADITLDPPPNCSAGPK(ub)GDNIYEWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELADITLDPPPNCSAGPKGDNIYEWR 26 1 C9J2P0;P51965;H7C061;B7Z306;P51965-2 C9J2P0 UBE2E1 Ubiquitin-conjugating enzyme E2 E1 1 69150000.0 13727000.0 21164000.0 34259000.0 True False 20824862.578123942 17387118.844913248 27487693.633746877 1.0 0.8349211803768651 1.3199459795053865 24.311803639585637 -6.814848831381228 1.3939091741800649 0.9105337553814715 1.3294180432091942 0.8721480297426027 0.07199442345779783 0.20025930335836173 0.7658839841443321 0.04060008640421129 0.09373386699296365 1.5316204932376495e-07 6.814848831381228 0.4188842878277227 ELADITLDPPPNCSAGPK(ub)GDNIYEWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELADITLDPPPNCSAGPKGDNIYEWR 26 1 C9J2P0;P51965;H7C061;B7Z306;P51965-2 C9J2P0 UBE2E1 Ubiquitin-conjugating enzyme E2 E1 1 13832700.0 5707800.0 4179800.0 3945100.0 True False 4746288.598413613 4157282.587774657 4770002.169918556 1.0 0.8759017707360182 1.0049962346396022 22.178368395697056 -11.0852080429753 9.657661667139726 1.396095122574188 0.94044900268549 0.22101853548384898 0.05270259419698706 0.045559830155103294 0.00040196781879355816 0.005172440713942175 0.017009689135571538 8.218488599070333e-12 11.0852080429753 -0.45564611988869796 ELADITLDPPPNCSAGPK(ub)GDNIYEWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELADITLDPPPNCSAGPKGDNIYEWR 26 1 C9J2P0;P51965;H7C061;B7Z306;P51965-2 C9J2P0 UBE2E1 Ubiquitin-conjugating enzyme E2 E1 1 68444800.0 13727000.0 9979800.0 44738000.0 True False 17769872.099622965 9424415.357050752 36596143.05064463 1.0 0.5303592116034823 2.0594488719714032 24.082929961678087 -6.82426956333572 1.3534491033854192 0.7479052214003649 2.09594520903676 0.8938898378343937 0.2083275021462816 0.18799419421384062 0.675497933735903 0.12092340837372652 0.27842223331118066 1.4987542811688795e-07 6.82426956333572 1.3480399876363949 up ELAEDDSILK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELAEDDSILK 10 0 P56385 P56385 ATP5I ATP synthase subunit e, mitochondrial 1 11885000.0 2843700.0 2922400.0 6118900.0 True False 3728118.238429969 2486389.3114259783 5485774.924633374 1.0 0.6669287700684828 1.4714594800361298 21.830016185564087 -6.794267912805057 1.4791628054820252 0.8148745184350414 1.481060306946186 0.8148809576009355 0.142011558994965 0.22904536339244735 0.9898378972989625 0.07555108023327094 0.1763555498245941 1.6059502494618977e-07 6.794267912805057 0.6661857885111446 ELAEDDSILK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELAEDDSILK 10 0 P56385 P56385 ATP5I ATP synthase subunit e, mitochondrial 1 16054200.0 2938500.0 4295400.0 8820300.0 True False 2845218.925953579 6010575.62021508 6509998.826671899 1.0 2.1125177979759946 2.2880484757390205 21.440108234592735 -10.677427386789736 0.365117276742638 1.2772396742193916e-14 2.313943478814759 0.9992744907732526 0.015362229712229834 2.2624730289679307 0.1765827021420556 2.0715051241206193 0.04961469811253009 2.1017091414372926e-11 10.677427386789736 2.313943478814746 ELAEDDSILK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELAEDDSILK 10 0 P56385 P56385 ATP5I ATP synthase subunit e, mitochondrial 1 11907800.0 2938500.0 4191600.0 4777700.0 True False 2443492.947622273 4169019.0188325467 5776694.980411111 1.0 1.706171905627703 2.364113629234055 21.22051351002701 -6.9719766092223034 0.20556221827390725 0.6354140900207086 3.45314809883047 0.9999939718315163 0.0013675846218605828 0.07566638493864294 0.006683428351992232 0.020414682782302948 0.06889643124988074 1.0666535688508691e-07 6.9719766092223034 2.8177340088097615 ELAEDDSILK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELAEDDSILK 10 0 P56385 P56385 ATP5I ATP synthase subunit e, mitochondrial 1 36746000.0 6748000.0 16943000.0 13055000.0 True False 8735419.022966111 16000107.155906014 10679123.9556119 1.0 1.831635908230671 1.2225084941587385 23.0584454777159 -10.08245274095801 5.223645040232276 0.999991509643838 1.5270722011955207 0.4995755575616684 0.2486752254723898 2.458924763268058e-05 4.319078734572351e-06 0.24078262410688553 0.08025958390533461 8.270795047803372e-11 10.08245274095801 0.5270806915516827 ELAEDGYSGVEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELAEDGYSGVEVR 13 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 0 78392300.0 9822300.0 33568000.0 35002000.0 False True 12877130.419288503 28559785.247039173 31380328.80289224 1.0 2.217868757798694 2.4369038583229705 23.618307798727326 -10.525717658240184 0.35387137790798573 1.0896608016481305e-11 2.475453043173754 0.9991661159425951 0.018252979020395185 2.042561065514438 0.16912168646321257 1.8934729185718226 0.06416001644453015 2.9804534399721095e-11 10.525717658240184 2.475453043162857 ELAEDGYSGVEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELAEDGYSGVEVR 13 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 0 30516500.0 9672900.0 3495600.0 17348000.0 False True 9365839.084177764 4891411.309313182 12804038.371155625 1.0 0.5222608743701903 1.3670999742870027 23.158976820424034 -6.753275164104713 1.6375208989654142 0.720193835883211 1.369228555765293 0.6630081222638977 0.20079178291544866 0.2943738625708789 1.5539717154043668 0.09682030945917089 0.2342697583921124 1.764919233362883e-07 6.753275164104713 0.6490347198820821 ELAEDGYSGVEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELAEDGYSGVEVR 13 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 0 59964300.0 9822300.0 24775000.0 25367000.0 False True 13453869.747676827 23680358.580030918 19375837.04976421 1.0 1.7601150467596856 1.4401683242927166 23.681517860250217 -10.16979982546564 4.788604328039479 0.9999365046699995 1.6001416855290875 0.8242924810013661 0.13061770249663107 8.855465568281977e-05 1.5352833233388995e-05 0.1264833645581617 0.04215668220602687 6.763946666391815e-11 10.16979982546564 0.600205180859088 ELAEDGYSGVEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELAEDGYSGVEVR 13 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 0 18108200.0 9672900.0 5118500.0 3316800.0 False True 8043444.932127097 5090925.624557295 4010327.5448495275 1.0 0.6329285110442093 0.4985833282492546 22.93938209585831 -13.999999999999998 0.13975263497677057 2.75305759310214 0.3318276118408536 0.9996039213778646 0.0042176633694080415 11.93375847576177 0.1171078879249538 5.705926435124397 0.14905288648381076 1.0000000000000041e-14 13.999999999999998 -2.4212299812612863 ELAEEEPHLVEQFQK(ub)LSEAAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELAEEEPHLVEQFQKLSEAAGR 22 1 Q5QNY5;P40855;P40855-5;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 67153300.0 19630300.0 22349000.0 25174000.0 True False 19007146.871582955 31273072.24849536 18580174.196188126 1.0 1.6453322773683008 0.9775362037090803 24.18003865210857 -6.653907415014901 1.9941221851711295 1.4174379580775218 0.9803126054527904 0.2102790209534796 0.27516825224523633 0.4989951250070595 3.807568943204171 0.11172799375610233 0.30494864889836837 2.2186693559844203e-07 6.653907415014901 -0.4371253526247314 ELAEEEPHLVEQFQK(ub)LSEAAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELAEEEPHLVEQFQKLSEAAGR 22 1 Q5QNY5;P40855;P40855-5;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 143296700.0 34649000.0 100297000.0 8350700.0 True False 52565066.181206115 82398216.72596231 6700180.48475817 1.0 1.567547093765909 0.1274645115381539 25.647600992426483 -6.799785813261797 1.456767130826141 1.313222983954154 0.10768322740452099 0.8315513164458137 0.243090576376993 0.22105718292655158 0.9261800548193825 0.1312771632242824 0.3053449072221 1.5856750279205827e-07 6.799785813261797 -1.205539756549633 down ELAEEEPHLVEQFQK(ub)LSEAAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELAEEEPHLVEQFQKLSEAAGR 22 1 Q5QNY5;P40855;P40855-5;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 70654600.0 19630300.0 22795000.0 28229300.0 True False 16323464.219741188 22672198.81054674 34131916.11246408 1.0 1.3889330417453638 2.090972581125629 23.960443927542848 -6.961999973036825 0.4062656147323147 0.9639763722614688 2.5418249129541794 0.9998373333351674 0.00575796290547208 0.07899427964052257 0.018547392337569617 0.009033241054343031 0.058687907154515245 1.0914404042108373e-07 6.961999973036825 1.5778485406927105 up ELAEEEPHLVEQFQK(ub)LSEAAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELAEEEPHLVEQFQKLSEAAGR 22 1 Q5QNY5;P40855;P40855-5;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 195737000.0 34649000.0 117896000.0 43192000.0 True False 44853813.533899315 111334983.96108678 35331499.18734508 1.0 2.4821743167265535 0.7877033501430704 25.418727314518932 -6.675589513340579 1.9172928121331267 1.9414919265912145 0.7943282261426661 0.3040490520562086 0.6287992366894233 0.4484727995796637 3.1833401829231702 0.2635174644412576 0.6990291605879853 2.110622126249315e-07 6.675589513340579 -1.1471637004485484 ELAEQK(ub)ATEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELAEQKATEK 10 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 3521430.0 1065600.0 1504000.0 951830.0 True False 1397011.9192850806 1279609.062546083 853343.762198072 1.0 0.9159614494920857 0.6108349903233251 20.41391289917686 -6.947102617798 0.5898067256959405 1.0035288370277857 0.5079194554001475 0.9989537543085509 0.00540832490322978 0.08467072880503745 0.04094306509979735 0.005608122683581685 0.025560459667990802 1.1295289910122736e-07 6.947102617798 -0.49560938162763823 ELAEQK(ub)ATEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELAEQKATEK 10 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 3738490.0 1232900.0 1588700.0 916890.0 True False 1193762.264355341 2223076.1949610496 676729.0028896063 1.0 1.862243648790123 0.5668875814692095 20.1870841243647 -6.727261104596287 1.7331620983427514 1.5204631281553223 0.5680257075383102 0.5465743363683335 0.362550619749381 0.3413828340718536 2.0076736011542002 0.16585613328579238 0.4128516364146497 1.8738675710108872e-07 6.727261104596287 -0.9524374206170121 ELAEQK(ub)ATEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELAEQKATEK 10 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 3551400.0 1123600.0 872800.0 1555000.0 True False 1704583.3461630424 717042.0207824755 1247653.5684192884 1.0 0.4206553011306323 0.7319404892859672 20.70098771157492 -10.097701461696705 5.34973484400028 1.0000063096125462 0.5762978952080239 0.7118373423801252 0.12708164591217458 9.563697059279994e-06 1.613293747566322e-06 0.12304810550777265 0.04101542485205679 7.985434252560832e-11 10.097701461696705 -0.42370841440452234 ELAEQK(ub)ATEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELAEQKATEK 10 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 3346800.0 1065600.0 1063800.0 1217400.0 True False 1459581.1167572206 1016797.7984838309 929875.1931400219 1.0 0.6966367177610999 0.6370836005373538 20.477122960699752 -13.999999999999998 0.22889531913138642 2.9053042398731037 0.6078223374482097 0.9995083042853874 0.003523797690065341 13.257055761234605 0.15149316545059763 11.472475130011185 0.03112711668546717 1.0000000000000041e-14 13.999999999999998 -2.2974819024248943 ELAEQK(ub)ATEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELAEQKATEK 10 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 3387150.0 1232900.0 1630900.0 523350.0 True False 1025210.9767308158 1622114.0179916946 632780.0653030027 1.0 1.582224590653797 0.6172193623217013 19.967489399798975 -6.743358466050124 1.6743432415662622 1.3450775944758429 0.6162273338576509 0.6198744214391994 0.2446175502603721 0.3118104762037756 1.7175919216182898 0.11551705740486738 0.28243647831180413 1.8056831024764418e-07 6.743358466050124 -0.7288502606181919 ELAEQK(ub)ATEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELAEQKATEK 10 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 2767100.0 1123600.0 562200.0 1081300.0 True False 1454522.349467209 530913.0757864811 884514.495074926 1.0 0.36500853766939667 0.6081133750876522 20.47211403366737 -10.26311383519007 5.595530861699279 1.0000386562404529 0.4865609563785489 0.8560618750891732 0.09924713427954368 4.786442445661299e-05 6.303428833658063e-06 0.0961028347412211 0.03203187485195035 5.45614828400307e-11 10.26311383519007 -0.513477699861904 ELAEQLGLSTGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELAEQLGLSTGEK 13 0 O75821;K7EL20;K7ER90 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 14791700.0 1937900.0 5925500.0 6928300.0 False True 2540605.6666502976 5041438.497418099 6211425.9769464135 1.0 1.9843451361206577 2.444860317554108 21.276741038018805 -9.668683246374759 0.20244980111745267 9.236311644464178e-24 2.868370435592106 0.9994374387076116 0.014293762948064918 1.1124928777296306 0.0850042820930773 0.9214791575105571 0.2660875271309413 2.1444540931409733e-10 9.668683246374759 2.868370435592106 ELAEQLGLSTGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELAEQLGLSTGEK 13 0 O75821;K7EL20;K7ER90 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 15239000.0 4087000.0 0.0 11152000.0 False True 3957260.4221106987 0.0 8230956.647171291 1.0 0.0 2.079963350701371 21.91607057962465 -6.7759770633785505 1.551547400878333 0.43080664766532856 2.0944038041529707 0.7528753419987786 0.42222607688476116 0.25688755169013905 1.2211518869514335 0.21440104567230656 0.5076235772710503 1.675031337995903e-07 6.7759770633785505 1.6635971564876422 ELAEQLGLSTGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELAEQLGLSTGEK 13 0 O75821;K7EL20;K7ER90 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 13443900.0 1937900.0 5815200.0 5690800.0 False True 2654393.999778357 5558265.235705177 4346750.245704968 1.0 2.0939865129929074 1.6375678388618735 21.339951099541697 -10.184344724065864 4.898212046921324 0.9999124706640686 1.8657771759294346 0.8275148847639526 0.18633214345684057 0.00017812480676332644 2.966131120502962e-05 0.18043338143004076 0.06013844070494906 6.541167585240817e-11 10.184344724065864 0.865864705265366 ELAEQLGLSTGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELAEQLGLSTGEK 13 0 O75821;K7EL20;K7ER90 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 5554800.0 4087000.0 0.0 1467800.0 False True 3398521.5847991286 0.0 1774710.1936595906 1.0 0.0 0.522200653836508 21.696475855058928 -10.669238486001213 6.5209484816099215 1.0051488078188069 0.26110032691825497 0.7274855622229831 0.21318752420786594 0.01597362201636898 0.0008102275450352824 0.2066187578048412 0.06880597757302127 2.1417141893992465e-11 10.669238486001213 -0.7440484809005519 ELAEQLGLSTGEK(ub)EKLPGELEPVQATQNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELAEQLGLSTGEKEKLPGELEPVQATQNK 29 2 O75821;K7EL20;K7ER90 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 1 95159800.0 22373000.0 63075000.0 9711800.0 True False 28962289.537762426 59564820.802618876 7944352.051483098 1.0 2.0566337038014693 0.2742998629692197 24.78767231960963 -6.7460665664078645 1.6642097401660105 1.6242211832199562 0.2717490960232995 0.6319808913458614 0.44394560689265783 0.3069426024887426 1.6712692575993824 0.21083564872690358 0.5140222851463447 1.7944585604426344e-07 6.7460665664078645 -1.3524720871966567 ELAETIK(ub)CR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELAETIKCR 9 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WYT6 P52701 MSH6 DNA mismatch repair protein Msh6 1 23641800.0 0.0 3624700.0 20017100.0 True False 0.0 2977843.9650896355 16060711.411193412 0.0 ELAETIK(ub)CR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELAETIKCR 9 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WYT6 P52701 MSH6 DNA mismatch repair protein Msh6 1 6298200.0 1497150.0 806650.0 3994400.0 True False 2050686.8139574605 771009.5357651636 3051004.987250291 1.0 0.37597624879503294 1.487796657434196 20.967675745953667 -6.754398134466172 1.6334854049794647 0.6350213339088402 1.4907819757489984 0.6677223964844424 0.2622971030438263 0.29242840133144254 1.5364342849685677 0.1267772239762626 0.30638322148578656 1.760361515321506e-07 6.754398134466172 0.8557606418401582 ELAETIK(ub)CR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELAETIKCR 9 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WYT6 P52701 MSH6 DNA mismatch repair protein Msh6 1 27465400.0 0.0 1041400.0 26424000.0 True False 0.0 983445.1745358262 21615103.133135874 0.0 ELAEYHQAK(ub)ESCNMETQTSSTFNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELAEYHQAKESCNMETQTSSTFNR 24 1 O75665;O75665-3;A6NF31;O75665-2;A0A0A0MS89 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 164110400.0 6473000.0 27721400.0 129916000.0 True False 9820014.239687929 22774299.581713233 104238045.65579426 1.0 2.3191717471925966 10.614856874088082 23.2272936858715 -6.934848701256025 0.7058546899043886 0.8936403345731373 12.549245125790343 0.9974083825022408 0.2166523641000894 0.09019710600659107 0.06591082993454303 0.2034212121302535 0.7316417005735405 1.1618533077447115e-07 6.934848701256025 11.655604791217206 ELAEYHQAK(ub)ESCNMETQTSSTFNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELAEYHQAKESCNMETQTSSTFNR 24 1 O75665;O75665-3;A6NF31;O75665-2;A0A0A0MS89 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 147161500.0 6473000.0 24852500.0 115836000.0 True False 8379426.101905688 23469436.527896747 94755036.57772972 1.0 2.8008405638375664 11.308058025140896 22.99842000796395 -6.941079712899632 0.6494443825008132 0.9060029418740032 13.676909871566297 0.9983018860824974 0.18524431179688675 0.08727759462226961 0.052392998121817635 0.18183170294594997 0.7287868744220615 1.1453027067258529e-07 6.941079712899632 12.770906929692293 ELAFQISK(ub)EYER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELAFQISKEYER 12 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;A0A0D9SEM9;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;A0A140T996;F6R6M7;A0A140T9K1;A0A140T973;A0A140T9L4;A0A140T9N3;A0A140T9K2;F6QYI9;A0A0G2JJL7 O00148;Q13838-2;F6QYI9 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 1 16278600.0 4395500.0 6369200.0 5513900.0 True False 5762543.066082549 5418940.186947145 4943374.521063594 1.0 0.9403730479416633 0.8578460003465386 22.458274196816962 -6.9665604994544985 0.33019203065159275 1.0100319430019404 0.7854847653803606 0.9999417686750312 0.00044472908297549 0.0774355106819731 0.013015029182904017 0.0012033768552951864 0.007197068571179521 1.0800391553938506e-07 6.9665604994544985 -0.22454717762157983 ELAFQISK(ub)EYER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELAFQISKEYER 12 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;A0A0D9SEM9;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;A0A140T996;F6R6M7;A0A140T9K1;A0A140T973;A0A140T9L4;A0A140T9N3;A0A140T9K2;F6QYI9;A0A0G2JJL7 O00148;Q13838-2;F6QYI9 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 1 15645100.0 4395500.0 5204100.0 6045500.0 True False 6020635.133921129 4974165.654342633 4617677.4109807825 1.0 0.8261861985818514 0.7669751294118656 22.521484258339854 -13.999999999999998 0.15032333223132946 1.840883189292268 0.7020727452063644 0.9995651610275208 0.002062179551717341 11.958960509894785 0.12212313219926352 2.9370584469586585 0.058517709497879 1.0000000000000041e-14 13.999999999999998 -1.1388104440859035 ELAFQISK(ub)EYER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELAFQISKEYER 12 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;A0A0D9SEM9;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;A0A140T996;F6R6M7;A0A140T9K1;A0A140T973;A0A140T9L4;A0A140T9N3;A0A140T9K2;F6QYI9;A0A0G2JJL7 O00148;Q13838-2;F6QYI9 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 1 61347500.0 9347500.0 10804000.0 41196000.0 True False 12100523.016771724 10202747.902520718 33698750.70665558 1.0 0.8431658605482898 2.784900343559365 23.528566070173863 -6.887333595330439 1.0379910725937276 0.8889027476930071 2.943458728310451 0.979137386890662 0.12720836282364772 0.12133471534061187 0.2346803410934466 0.09368699699896123 0.2314376312048809 1.296183249136615e-07 6.887333595330439 2.054555980617444 up ELAGHTGYLSCCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELAGHTGYLSCCR 13 0 P62873;P62873-2;F6UT28;F6X3N5;B3KVK2 P62873;B3KVK2 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0 6904120.0 795720.0 3272300.0 2836100.0 False True 1043196.6257634425 2784085.595325494 2542647.577792205 1.0 2.668802339432432 2.4373617734158404 19.99257967759263 -10.568885960491466 6.750436907043496 0.998090207095133 2.553082056424136 0.9836175928866766 0.0944852154202623 0.002716649056779153 0.00017349740019284687 0.0915164490420406 0.030494972148791363 2.6984479131820243e-11 10.568885960491466 1.554991849329003 ELAGHTGYLSCCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELAGHTGYLSCCR 13 0 P62873;P62873-2;F6UT28;F6X3N5;B3KVK2 P62873;B3KVK2 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0 6277820.0 795720.0 2766200.0 2715900.0 False True 1089919.1875244514 2643980.137399858 2074460.3557162674 1.0 2.425849703045569 1.903315749884189 20.05578973911552 -10.485909863513141 7.458041097419712 0.9998293662330614 2.164582726464879 0.8688169062004503 0.21332359308745755 0.0006053275791381852 4.172576670081439e-05 0.2065781645563688 0.06884989361507084 3.266556215090882e-11 10.485909863513141 1.1647533602318179 ELAILLGMLDPAEKDEK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ELAILLGMLDPAEKDEK 17 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 25322840.0 6087600.0 8614000.0 10621240.0 False True 7980902.5524022635 7328824.777109021 9522255.97092827 1.0 0.9182952340275141 1.193130214083626 22.928120477957894 -6.827033917807952 1.3409669740929173 0.9562438516092852 1.2000951180162205 0.8998393324435981 0.03646935158799078 0.18449918400340412 0.6498581881368997 0.021358936759939398 0.04916667726826664 1.489244765179783e-07 6.827033917807952 0.24385126640693533 ELAILLGMLDPAEKDEK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ELAILLGMLDPAEKDEK 17 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 56959400.0 31697200.0 12182600.0 13079600.0 False True 30690989.736170053 17047175.711419743 9653660.38041083 1.0 0.555445616383275 0.3145437948856294 24.87131183541315 -9.445963124015147 0.16886559825155445 1.5458856108715076 1.3087639619151946e-09 0.9996995282735648 0.004921559063402251 0.8787259235750793 0.06535561764662635 0.4041253968706105 0.1677333076738507 3.5812684439534213e-10 9.445963124015147 -1.5458856095627436 ELAILLGMLDPAEKDEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELAILLGMLDPAEKDEK 17 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 42251500.0 11324500.0 26943000.0 3984000.0 False True 17180094.431847066 22134811.14338015 3196560.653750765 1.0 1.288398689028649 0.18606187913759312 24.034234630605436 -6.8371827748300955 1.2952807887645423 1.1535284039483076 0.15175216899859031 0.9195193627402337 0.13241671662997814 0.17211805093588825 0.5621335351078753 0.08019378198394987 0.1846484797709085 1.4548466728103777e-07 6.8371827748300955 -1.0017762349497172 down ELAILLGMLDPAEKDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ELAILLGMLDPAEKDEK 17 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 44432300.0 6087600.0 11607400.0 26737300.0 False True 8338350.231204252 11094546.687461182 20422500.411978573 1.0 1.3305445777442322 2.4492255477051468 22.991330539480785 -6.948713777830528 0.572789056342844 0.9862346171872637 2.8481862475663844 0.999096453033677 0.018640281891400087 0.08400634761107914 0.038131630564318286 0.0196859924867842 0.09327291407789448 1.1253463901766382e-07 6.948713777830528 1.8619516303791208 up ELAILLGMLDPAEKDEK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ELAILLGMLDPAEKDEK 17 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 43714990.0 31697200.0 3365790.0 8652000.0 False True 26357626.224050585 3347657.821212997 10461093.19767188 1.0 0.12700907861567423 0.3968905662728622 24.651717110847425 -10.265805386760784 5.519723186813195 1.0000653935416488 0.2619498226949789 0.9088554904164324 0.11017865596398498 8.867264170357372e-05 1.1794351259975299e-05 0.10668940227375 0.03556000830465556 5.422438227677886e-11 10.265805386760784 -0.7381155708466699 ELAILLGMLDPAEKDEK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ELAILLGMLDPAEKDEK 17 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 65540600.0 34835500.0 14568700.0 16136400.0 False True 45095241.460363984 13757939.038083436 13199740.773445902 1.0 0.30508627058080706 0.2927080628905754 25.426471869671513 ELAPYDENWFYTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELAPYDENWFYTR 13 0 P39019;M0R2L9;M0QYF7;M0R140 P39019 RPS19 40S ribosomal protein S19 0 12869400.0 1405400.0 6760000.0 4704000.0 False True 1842493.009912958 5751434.350273611 4217275.203954207 1.0 3.12155016020675 2.288896175597126 20.813227715329436 -10.431295252833525 5.9878513741538315 0.9993294029165455 2.705223167901938 0.8483024208514292 0.33992956576480476 0.003044085204828948 0.00028911549462878503 0.32923642690823457 0.10971179559088366 3.704288020742199e-11 10.431295252833525 1.7058937649853925 ELAPYDENWFYTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELAPYDENWFYTR 13 0 P39019;M0R2L9;M0QYF7;M0R140 P39019 RPS19 40S ribosomal protein S19 0 14746000.0 6444200.0 1474700.0 6827100.0 False True 6239632.398376739 2063555.4004589065 5038877.70139017 1.0 0.3307174635793845 0.8075600259241315 22.57302960599812 -9.837285822252312 6.145777808927288 1.0000000308002661 0.5691387447517937 0.5212076593332331 0.19467016089854985 8.222850584384734e-08 1.553843459622143e-08 0.1884885868339613 0.06282952426350157 1.4545015143498132e-10 9.837285822252312 -0.4308612860484724 ELAPYDENWFYTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELAPYDENWFYTR 13 0 P39019;M0R2L9;M0QYF7;M0R140 P39019 RPS19 40S ribosomal protein S19 0 18103100.0 1405400.0 8307500.0 8390200.0 False True 1925014.359506938 7940447.180771222 6408607.561593079 1.0 4.124876856921235 3.3291219517108135 20.876437776852327 -9.759872391340853 6.973326538250493 0.9999999938642127 3.726999404316189 0.9399705878215443 0.32486557968098273 2.9775357993499156e-08 5.3772400288287915e-09 0.31454974262127056 0.10484991498828385 1.7383115214375686e-10 9.759872391340853 2.7269994104519766 ELAQQVQQVADDYGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELAQQVQQVADDYGK 15 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 11486100.0 3704700.0 0.0 7781400.0 False True 3587096.3263502573 0.0 5743217.903003825 1.0 0.0 1.6010771332832716 21.774385056655266 -6.737836882230653 1.6947113925862667 0.40351011509896 1.6015605322745785 0.5951342917377387 0.4201842625858468 0.321752767124915 1.8136196257417487 0.19621577534882956 0.4826261841939316 1.82878696591477e-07 6.737836882230653 1.1980504171756186 ELAVQIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELAVQIQK 8 0 P38919 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 13178500.0 4452900.0 4691100.0 4034500.0 False True 5837795.021944936 3991206.165764582 3617048.6416567275 1.0 0.6836838482271446 0.6195915800503152 22.47699212480033 -13.999999999999998 0.22441624324965528 2.9465852280105613 0.5867262903101992 0.9995026972334451 0.0037083325756386426 13.123555622456008 0.15003828929969815 11.347920553142881 0.034465035122101514 1.0000000000000041e-14 13.999999999999998 -2.3598589377003623 ELAVQIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELAVQIQK 8 0 P38919 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 6749900.0 1708500.0 1251500.0 3789900.0 False True 1654264.6026856191 1751230.4764862824 2797211.495437095 1.0 1.0586156976600019 1.6909093568803664 20.65775858403326 -6.924988699964896 0.7868320271361784 0.9883935409638226 1.8055724595639635 0.9954584694879557 0.0210797732743777 0.09532447001104842 0.09104643115860692 0.018660145898458422 0.05886644733688764 1.1885331518262837e-07 6.924988699964896 0.8171789186001409 ELAVQIQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELAVQIQK 8 0 P38919 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 27923200.0 2570100.0 21002000.0 4351100.0 False True 3899029.5994781298 17254029.010625023 3491103.1778451228 1.0 4.425211086608424 0.895377449381865 21.89468367631882 -6.653059926153793 1.9975248358871207 3.217307095124747 0.9102352414314053 0.20642947902269682 1.4608438532991896 0.5011928738455658 3.8365854221410456 0.5923864307478343 1.6184485308862173 2.223003128248862e-07 6.653059926153793 -2.307071853693342 ELAVQIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELAVQIQK 8 0 P38919 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 11892400.0 4452900.0 2658100.0 4781400.0 False True 6099257.4650978 2540656.3528387574 3652131.7960240683 1.0 0.41655174705729836 0.5987830185760993 22.54020218632322 -10.305422506204332 5.307696744014182 1.0001013099046436 0.5076673828166693 0.9068222874328983 0.07439560506672314 8.920636707546043e-05 1.1673694111608768e-05 0.07204794545359985 0.02401107828785339 4.949684232556283e-11 10.305422506204332 -0.4924339270879743 ELAVQIQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELAVQIQK 8 0 P38919 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 10890700.0 2570100.0 4416600.0 3904000.0 False True 3327045.1142449863 4170812.327496581 3193512.0584227433 1.0 1.2536085878844694 0.9598643687605823 21.66580999841127 -6.678313255532433 1.907995044153359 1.1607039065721 0.9609995014175302 0.3163887546756158 0.10752524259257039 0.44227018861998874 3.1114457136399083 0.04524554030498945 0.1195855419502947 2.097426469368943e-07 6.678313255532433 -0.1997044051545699 ELCEK(ub)AIEVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELCEKAIEVGR 11 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 20577300.0 6089800.0 8452300.0 6035200.0 True False 7983786.773707098 7191249.786807357 5410735.397726285 1.0 0.900731694199325 0.6777154188968811 22.928641759861172 -6.957709100533687 0.46660363744845224 1.00608912072921 0.5632675729082822 0.9996755571767271 0.0024274452144531214 0.08052989877305516 0.02423396103334581 0.0030642475746960034 0.018411615281645515 1.1022773906185107e-07 6.957709100533687 -0.44282154782092775 ELCEK(ub)AIEVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELCEKAIEVGR 11 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 12391800.0 6497000.0 4110600.0 1784200.0 True False 6290756.291277995 5751984.016495816 1316864.495147331 1.0 0.9143549281142593 0.20933325568074168 22.584802041450406 -6.929568452318384 0.7503307360502754 1.0108949206355082 0.0661761452234128 0.9964526322847591 0.021100051412153924 0.09286273476585243 0.07878391166789284 0.01917396958401839 0.06394448120473913 1.1760656018047936e-07 6.929568452318384 -0.9447187754120955 down ELCEK(ub)AIEVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELCEKAIEVGR 11 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 55817600.0 11228000.0 13650000.0 30939600.0 True False 17033696.87675207 11214050.85206321 24824374.498691596 1.0 0.6583450987300573 1.4573685723251537 24.02188824584841 -6.790520147001521 1.4942159664760002 0.8091732086483671 1.4659913156732862 0.8029900270523499 0.14529169058947586 0.23459297698279258 1.0347109749525796 0.07653268380321493 0.1791170359134842 1.6198688461445343e-07 6.790520147001521 0.6568181070249192 ELCEK(ub)AIEVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELCEKAIEVGR 11 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 17782300.0 6089800.0 5276400.0 6416100.0 True False 8341363.630657021 5043271.201278512 4900749.323727362 1.0 0.6046099204622819 0.5875237599899894 22.991851821384063 ELCEK(ub)AIEVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELCEKAIEVGR 11 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 14960100.0 6497000.0 1860900.0 6602200.0 True False 5402543.3659016155 1850874.9623402702 7982689.4948762385 1.0 0.3425932633918585 1.4775799015810454 22.365207316884682 -6.749632334774583 1.650963693529579 0.6132775426674397 1.4798117068480754 0.6475222026878544 0.27624248363212367 0.30066634976731543 1.6122525189791492 0.13217751921987275 0.3210456774222059 1.7797855040777332e-07 6.749632334774583 0.8665341641806357 ELCEK(ub)AIEVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELCEKAIEVGR 11 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 57069900.0 11228000.0 13610000.0 32231900.0 True False 14534867.336968508 12852591.535848485 26366024.927222338 1.0 0.8842592944181017 1.8139845597463442 23.79301456794086 -6.87570522411029 1.1034194887751825 0.9316290943602001 1.8746920618431677 0.97005536237272 0.07158941360080937 0.13150493517268 0.2958246541120863 0.05015463863164162 0.1200738214597132 1.3313577658875295e-07 6.87570522411029 0.9430629674829676 ELCQSVMPAGVDK(ub)ISTAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELCQSVMPAGVDKISTAQK 19 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 6237100.0 1919100.0 2072200.0 2245800.0 True False 2515958.684590838 1763035.837372335 2013426.1592347731 1.0 0.7007411720113567 0.800262012077599 21.262676800752303 -10.734949263533906 9.884585428887899 1.0005986198739518 0.7505015920444779 0.8933906743994895 0.04062921282257094 0.000537168225083644 1.4403900358529866e-05 0.03942614089385709 0.013113022052611162 1.8409870622761672e-11 10.734949263533906 -0.25009702782947396 ELDALDANDELTPLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELDALDANDELTPLGR 16 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 9484800.0 2934700.0 1460900.0 5089200.0 False True 2841539.554873563 2044244.9884928581 3756185.8472726108 1.0 0.7194145810804379 1.321884061346366 21.438241367494605 -6.780098878764012 1.5358218845322882 0.8411438061168488 1.3266424813788873 0.7676205071602697 0.11865831622462368 0.25042566831747615 1.166790347313306 0.06085580549788711 0.14356209257752114 1.6592091010647115e-07 6.780098878764012 0.4854986752620385 ELDDRDHYGNK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELDDRDHYGNKR 12 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 10098400.0 1394900.0 2889100.0 5814400.0 True False 1828727.4082308167 2458057.5416235975 5212781.663663126 1.0 1.3441355614621753 2.8504968210140063 20.802408611003212 -6.942809890584171 0.6328817612008273 0.983562491586713 3.2926567095786785 0.9985092789054899 0.031026708430037384 0.08650778799444267 0.04894518712607619 0.030888899306147837 0.12813105204610292 1.1407490333085664e-07 6.942809890584171 2.3090942179919653 up ELDDRDHYGNK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELDDRDHYGNKR 12 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 12928900.0 2390800.0 2928500.0 7609600.0 True False 2314905.362657758 4097865.321925753 5616417.476893357 1.0 1.7702085744105611 2.426197445257594 21.142521784142236 -6.972988569194334 0.17245399067594863 0.4392212883217762 3.7747933276188825 0.9999972928093174 0.0009590016197510822 0.07534438535441487 0.005393487817188217 0.02703142683404406 0.07538813107306275 1.0641710272657176e-07 6.972988569194334 3.3355720392971064 ELDDRDHYGNK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELDDRDHYGNKR 12 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 38231600.0 3542100.0 8345500.0 26344000.0 True False 5373624.662196607 6856180.321310882 21137096.85301462 1.0 1.2758949037777123 3.9334896241849324 22.357464124598124 -6.926814226793288 0.7724969843371051 0.9544558728766086 4.4373022666394535 0.9958741913534135 0.08495614795947225 0.09432601270595982 0.08603447010155611 0.07597988056429461 0.24481363718352722 1.1835477201946353e-07 6.926814226793288 3.482846393762845 up ELDDRDHYGNK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELDDRDHYGNKR 12 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 11635700.0 1394900.0 3880300.0 6360500.0 True False 1910632.2257551108 3708855.5155638335 4858280.898609419 1.0 1.9411666282861095 2.542760889887824 20.865618672526104 -8.494513053600159 0.16106303754108647 4.826541069589397e-16 3.539519418593834 0.9998656722190027 0.0073584184901516695 0.15458477516289668 0.04064237369080369 0.4232539091037195 0.3653868764785659 3.2024838360452582e-09 8.494513053600159 3.5395194185938337 ELDDRDHYGNK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELDDRDHYGNKR 12 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 12077400.0 2390800.0 4654600.0 5032000.0 True False 1988056.1303982765 4629524.7459342405 6084167.934660765 1.0 2.3286690326026087 3.0603602391457105 20.922927059576512 -8.930706178676667 0.21204880392294884 1.67498341508119e-21 3.766176570404248 0.9995029285772251 0.019013850609203423 0.42031339260378386 0.06878457916731702 0.6628478055790004 0.366815318716493 1.1729886810085476e-09 8.930706178676667 3.766176570404248 ELDDRDHYGNK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELDDRDHYGNKR 12 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 36412100.0 3542100.0 5097000.0 27773000.0 True False 4585318.275229439 4813347.469376905 22718598.975044753 1.0 1.0497302870728327 4.954639484411356 22.128590446690573 -6.909676249577697 0.8979165515740685 0.8778542527028096 5.45583848917479 0.9907992809220209 0.1777044568959614 0.10463305649450759 0.13992383614545958 0.14525644416603364 0.40009009597140455 1.2311862324577512e-07 6.909676249577697 4.5779842364719805 up ELDGHVLK(ub)CVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELDGHVLKCVK 11 1 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72;H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;H0YDK8;H0YC97 A0A0C4DG68;H0YEH2 PUM2;PUM1 Pumilio homolog 2;Pumilio homolog 1 1 26499800.0 7101700.0 9724000.0 9674100.0 True False 9310397.472960629 8273217.103855121 8673116.93251987 1.0 0.8885997754534434 0.9315517364009908 23.150411328948064 -10.518659715811461 8.175714124487342 1.0000104370132323 0.9100757561108898 0.8538912358540924 0.017535064628906825 3.336281137849318e-06 1.964211638172881e-07 0.01698022321408251 0.005659417773535571 3.029286044958945e-11 10.518659715811461 -0.08993468090234258 ELDGHVLK(ub)CVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELDGHVLKCVK 11 1 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72;H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;H0YDK8;H0YC97 A0A0C4DG68;H0YEH2 PUM2;PUM1 Pumilio homolog 2;Pumilio homolog 1 1 16996400.0 8036700.0 3778900.0 5180800.0 True False 7781579.357567162 5287834.47670317 3823793.0593315116 1.0 0.6795322946312998 0.4913903571018756 22.891631565163884 -10.047300667761553 0.10405983234355481 1.7955634967503153 5.643757942221252e-11 0.9999189817413207 0.00188992010527631 1.668822280300282 0.0492740693957708 0.6130329922073271 0.26451007806822 8.96807707802925e-11 10.047300667761553 -1.7955634966938778 ELDGHVLK(ub)CVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELDGHVLKCVK 11 1 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72;H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;H0YDK8;H0YC97 A0A0C4DG68;H0YEH2 PUM2;PUM1 Pumilio homolog 2;Pumilio homolog 1 1 109117000.0 19205000.0 33890000.0 56022000.0 True False 29135389.073568135 27842064.71622145 44949227.1446851 1.0 0.9556098477325639 1.5427707874841254 24.79626924075431 -6.888668422026215 1.0301888993177561 0.9674368218674716 1.5919811526143348 0.9800336228134043 0.037719738548369984 0.12023180303977109 0.22819249860113017 0.027944904025986955 0.06934388518655625 1.2922054785261274e-07 6.888668422026215 0.6245443307468632 ELDGHVLK(ub)CVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELDGHVLKCVK 11 1 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72;H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;H0YDK8;H0YC97 A0A0C4DG68;H0YEH2 PUM2;PUM1 Pumilio homolog 2;Pumilio homolog 1 1 26488600.0 7101700.0 7866900.0 11520000.0 True False 9727390.406226296 7519314.345640574 8799213.261847423 1.0 0.773004272639003 0.9045810740993014 23.213621390470955 -10.193043590462878 5.001264901238072 1.0000148450460498 0.8387926734304039 0.666830200865059 0.053716004261578486 8.892170379953507e-06 1.4347618629216501e-06 0.05201508551483592 0.017336765827390296 6.411452211287968e-11 10.193043590462878 -0.1612221716156459 ELDGHVLK(ub)CVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELDGHVLKCVK 11 1 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72;H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;H0YDK8;H0YC97 A0A0C4DG68;H0YEH2 PUM2;PUM1 Pumilio homolog 2;Pumilio homolog 1 1 23841300.0 8036700.0 3991600.0 11813000.0 True False 6682872.136176928 3970096.4585294346 14283043.682859201 1.0 0.5940703903397752 2.137261254115525 22.67203684059816 -6.836782193858705 1.2971892423599496 0.783883347115814 2.1848902703856776 0.9187924903076604 0.1861309974368757 0.1725881455585541 0.5655065753295424 0.11256776431013149 0.2591629365639213 1.4561892013758468e-07 6.836782193858705 1.4010069232698636 up ELDGHVLK(ub)CVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELDGHVLKCVK 11 1 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72;H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;H0YDK8;H0YC97 A0A0C4DG68;H0YEH2 PUM2;PUM1 Pumilio homolog 2;Pumilio homolog 1 1 75951000.0 19205000.0 37706000.0 19040000.0 True False 24861251.087146394 35607627.953762166 15574915.366897786 1.0 1.4322540659336245 0.6264735154438881 24.56739556284676 -6.761010156972032 1.6087889307891974 1.2507681984253876 0.6233966116570498 0.6950001884922263 0.18183399869925881 0.281240576117915 1.4348793613601851 0.08917005620619196 0.21406611978136333 1.7337634492472575e-07 6.761010156972032 -0.6273715867683377 ELDPTNMTYITNQAAVYFEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELDPTNMTYITNQAAVYFEK 20 0 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 40606900.0 0.0 35361000.0 5245900.0 False True 0.0 29050553.273245964 4209045.565640348 0.0 ELDPTNMTYITNQAAVYFEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELDPTNMTYITNQAAVYFEK 20 0 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 9333500.0 5420300.0 2108500.0 1804700.0 False True 4507219.6100040795 2097141.0919955198 2182054.426009994 1.0 0.46528487037569083 0.4841242750113121 22.103806315038653 -10.263984796150265 8.611085854788657 1.0000002412756666 0.4747045727136958 0.9990362378697651 0.0076911547358493645 3.561813697956156e-08 3.041247535319977e-09 0.007446931880127895 0.002482309517087408 5.4452171521085816e-11 10.263984796150265 -0.5252956685619707 ELDQK(ub)TWLNSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELDQKTWLNSK 11 1 A8MTT3 A8MTT3 CEBPZOS Protein CEBPZOS 1 12265900.0 3540700.0 4066400.0 4658800.0 True False 5371500.7598429015 3340719.149071786 3737986.137975422 1.0 0.6219340363957225 0.6958923222948117 22.356893792784845 -10.823084420905785 7.2582381132752065 1.0177324824990082 0.6589131793452672 0.9659391982874124 0.03019334378394077 0.008379197956800711 0.00020423813174184094 0.028273884838908827 0.009744859803459821 1.502849804253056e-11 10.823084420905785 -0.358819303153741 ELDQWIEQLNECK(ub)QLSESQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELDQWIEQLNECKQLSESQVK 21 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 81312000.0 32339000.0 36567000.0 12406000.0 True False 42396742.17132148 31111346.137049615 11122346.126755094 1.0 0.7338145466774645 0.26233964114060176 25.337450074427995 -7.054808401979329 0.4234986498567763 1.0211853096495913 2.014956982452824e-15 0.999805605461636 0.004252627193829518 0.07358235019933852 0.02020481652672356 0.00636281394979466 0.036640451877114524 8.81437651749394e-08 7.054808401979329 -1.0211853096495893 down ELDQWIEQLNECK(ub)QLSESQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELDQWIEQLNECKQLSESQVK 21 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 346264150.0 196530000.0 104822150.0 44912000.0 True False 190291262.72508296 146678181.13529074 33148199.86888067 1.0 0.7708088066407927 0.17419717224101056 27.503634080497616 -7.105385860152266 0.5662837184493017 1.0050134957423762 6.728630902095397e-14 0.9990394350998825 0.010787972019564922 0.07720263625646308 0.039157784699530254 0.0113855351743283 0.04545946889566443 7.845382815608032e-08 7.105385860152266 -1.005013495742309 down ELDQWIEQLNECK(ub)QLSESQVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELDQWIEQLNECKQLSESQVK 21 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 1228187300.0 558878000.0 488026000.0 181283300.0 True False 847858785.4547051 400933947.3354587 145452576.295707 1.0 0.4728782129920828 0.1715528326072614 29.659248756800967 -8.640045881181486 0.28066816552218243 1.2166385989569406 1.3200665203004061e-20 0.9989548989268174 0.011068270270491471 0.2353254860796875 0.08183614359409372 0.14992199799688175 0.10249418262145128 2.2906256460947846e-09 8.640045881181486 -1.2166385989569406 ELDQWIEQLNECK(ub)QLSESQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELDQWIEQLNECKQLSESQVK 21 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 124422000.0 32339000.0 25384000.0 66699000.0 True False 44295602.22861458 24262450.946337216 50946069.909024335 1.0 0.5477394984069971 1.1501383285429994 25.400660135950886 -6.7057602923619 1.8099234022684154 0.7207752185115556 1.1485793020252837 0.44516550521951825 0.1907101264303441 0.38364204298419885 2.4469738779040218 0.08393026483342078 0.21435726127114121 1.9689727589108563e-07 6.7057602923619 0.4278040835137281 ELDQWIEQLNECK(ub)QLSESQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELDQWIEQLNECKQLSESQVK 21 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 380396200.0 196530000.0 56638000.0 127228200.0 True False 163423402.7552169 56332879.85223723 153831028.38326818 1.0 0.34470509671503546 0.9413035452069456 27.284039355931892 -10.659433043921169 9.572063135990536 1.0001962160613973 0.643004320961001 0.3231443036143222 0.24356029669021534 0.0010204205283920673 3.630576861359932e-05 0.23595144569077256 0.07860874773987842 2.190619534381357e-11 10.659433043921169 -0.3571918951003963 ELDQWIEQLNECK(ub)QLSESQVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELDQWIEQLNECKQLSESQVK 21 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 1134004000.0 558878000.0 474916000.0 100210000.0 True False 723478588.132372 448486507.11528397 81972808.24143012 1.0 0.6199029445681759 0.11330371013887128 29.430375078893416 -7.555859176993902 0.4979927161023099 1.015635283536921 1.551628174511078e-21 0.996726974225223 0.020779842257092774 0.11746499285611009 0.07589319759637927 0.023988443917368006 0.07107376315061721 2.7806147552670285e-08 7.555859176993902 -1.015635283536921 down ELDQWVEQLNECK(ub)QLNENQVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELDQWVEQLNECKQLNENQVR 21 1 P62714;E5RJX4 P62714 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 30669600.0 8778700.0 15665000.0 6225900.0 True False 11508960.713051725 13327843.061691755 5581703.591049857 1.0 1.1580405384977401 0.48498763096131975 23.456254224717053 -6.844826636737478 1.2598663751501014 1.084093637949977 0.46065950666441574 0.9324295720292066 0.07469890650416938 0.16323430898500688 0.5012097018126886 0.04645212534898554 0.10719203459240924 1.429464463497425e-07 6.844826636737478 -0.6234341312855614 down ELDQWVEQLNECK(ub)QLNENQVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELDQWVEQLNECKQLNENQVR 21 1 P62714;E5RJX4 P62714 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 66190000.0 44053000.0 13918000.0 8219000.0 True False 42654561.628393084 19475529.981411178 6066197.33528523 1.0 0.4565872731522168 0.1422168486487798 25.34619670087231 -8.56270336900576 0.31135084001100893 1.17316540956694 1.1410789766731245e-22 0.9985775086443287 0.01336370880164467 0.20105719493491522 0.08965735981948311 0.12745835639766803 0.09466544972732643 2.737137602535565e-09 8.56270336900576 -1.17316540956694 ELDQWVEQLNECK(ub)QLNENQVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELDQWVEQLNECKQLNENQVR 21 1 P62714;E5RJX4 P62714 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 218250000.0 103730000.0 87353000.0 27167000.0 True False 157365993.6787935 71764174.65789594 21797430.54228091 1.0 0.45603356214543334 0.13851423698802795 27.22954857153564 -8.537978012118817 0.3168247806406919 1.1648447062555463 1.1487526406922582e-24 0.9985074382336209 0.01374304699989897 0.190473845424951 0.09051280984785467 0.1219459442284334 0.09351645293619637 2.8974902809289157e-09 8.537978012118817 -1.1648447062555463 ELDQWVEQLNECK(ub)QLNENQVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELDQWVEQLNECKQLNENQVR 21 1 P62714;E5RJX4 P62714 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 56269700.0 8778700.0 15409000.0 32082000.0 True False 12024422.625447253 14728179.42925113 24504892.349530272 1.0 1.224855436973907 2.0379267356813155 23.519464286239945 -6.947195519100978 0.5888278021085273 0.9905688388874309 2.3130437106829262 0.9989624270710233 0.014361027930900364 0.08463179889980704 0.04077631025519636 0.014906646372085499 0.06809135290353006 1.1292873957428646e-07 6.947195519100978 1.3224748717954955 up ELDQWVEQLNECK(ub)QLNENQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELDQWVEQLNECKQLNENQVR 21 1 P62714;E5RJX4 P62714 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 71930000.0 44053000.0 11722000.0 16155000.0 True False 36632021.37880009 11658851.259365177 19532935.80771953 1.0 0.3182693943859855 0.5332202557357032 25.126601976306585 -10.204460646292626 4.940122147146775 1.0000674593728427 0.4257448250601002 0.904909930681857 0.08775332168277548 6.520737541603066e-05 1.0500866860264019e-05 0.0849767182873787 0.0283222627872166 6.245099378469768e-11 10.204460646292626 -0.5743226343127426 ELDQWVEQLNECK(ub)QLNENQVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELDQWVEQLNECKQLNENQVR 21 1 P62714;E5RJX4 P62714 PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 205098000.0 103730000.0 85113000.0 16255000.0 True False 134280529.82398862 80376386.72965994 13296756.790384654 1.0 0.5985706701858803 0.09902222465024299 27.00067489362809 -7.629471952637076 0.5002251465542563 1.0168784413676173 2.587885086021776e-23 0.996103800941908 0.023004656874711576 0.11766248506875444 0.08484422063972834 0.026976513646098134 0.07376959701682954 2.3470808356516294e-08 7.629471952637076 -1.0168784413676173 down ELEDATETADAMNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELEDATETADAMNR 14 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 14382590.0 4692100.0 955990.0 8734500.0 False True 4543151.85382569 1337721.7924219896 6446672.420616726 1.0 0.29444795936009116 1.4189867801112839 22.11526209728099 -6.737096432803132 1.6974272320653254 0.5787938976629886 1.419226110060104 0.5918105672062121 0.29646942957864175 0.32308662461937054 1.8266825081187974 0.13823996095602298 0.3403025257598058 1.831907611767666e-07 6.737096432803132 0.8404322123971154 ELEDFEMK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELEDFEMKK 9 1 Q9UG63;Q9UG63-2;C9JHK9;C9JZV3 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 11057600.0 1175700.0 3638400.0 6243500.0 True False 1783622.8551832384 2989099.0930510517 5009469.488376736 1.0 1.675858259140759 2.8085923399215993 20.766379160771887 -6.963348534628746 0.38535205678001455 0.9267257140001892 3.5981234426521973 0.9998749413190121 0.008344348621720553 0.07852600260875185 0.016864700777400515 0.014670416176252327 0.09547728017890961 1.0880565441400067e-07 6.963348534628746 2.671397728652008 ELEDFEMK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELEDFEMKK 9 1 Q9UG63;Q9UG63-2;C9JHK9;C9JZV3 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 10459800.0 1175700.0 2227100.0 7057000.0 True False 1521966.8265117442 2103159.9272217588 5772698.410934753 1.0 1.381869756019633 3.7929199969262326 20.537505482864336 -6.934766689914601 0.70657902352968 0.9690046727711616 4.353857400436572 0.9973947953053817 0.06311015662367232 0.09023742034670694 0.06610361366737227 0.05922384716466133 0.21273222808117384 1.1620727306238333e-07 6.934766689914601 3.384852727665411 up ELEDLQK(ub)KPPPYLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELEDLQKKPPPYLR 14 2 O14933 O14933 UBE2L6 Ubiquitin/ISG15-conjugating enzyme E2 L6 1 24158900.0 5770500.0 9437100.0 8951300.0 True False 7565181.381601482 8029121.465527684 8025105.342932669 1.0 1.0613257052969682 1.0607948359902808 22.85094324201073 -10.225779697114522 6.680580115776475 0.9999995893063724 1.0610602706436245 0.9999432713427591 0.00021672648691488464 1.3256114634370027e-09 1.537604973954849e-10 0.00020984592887141791 6.994817287527452e-05 5.945936993791766e-11 10.225779697114522 0.061060681337252065 ELEDLQK(ub)KPPPYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELEDLQKKPPPYLR 14 2 O14933 O14933 UBE2L6 Ubiquitin/ISG15-conjugating enzyme E2 L6 1 19690500.0 5770500.0 5415400.0 8504600.0 True False 7904009.79189895 5176129.721666984 6495988.637735027 1.0 0.6548739004564683 0.8218598924805173 22.91415330353362 -10.10140724990598 4.889512495284859 1.0000105684702432 0.7383668964668505 0.7659798275148958 0.06817174578090282 18017960.614472304 37223907.778048955 1329.8840445866495 0.023337000766228567 7.917585284668481e-11 10.10140724990598 -0.26164367200339267 ELEDLQK(ub)KPPPYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELEDLQKKPPPYLR 14 2 O14933 O14933 UBE2L6 Ubiquitin/ISG15-conjugating enzyme E2 L6 1 13146500.0 4488100.0 4530700.0 4127700.0 True False 3732054.006541953 4506292.219826461 4990782.9856715435 1.0 1.2074563261751674 1.3372751243479202 21.831538432900366 -10.823268095041863 0.05978108148379633 6.109549177106141e-08 2.0248247928539196 0.9999836183669405 0.0005621682038007008 3.078048494741647 0.03594664607165296 0.8483215130177949 0.42131917635884675 1.5022143453923998e-11 10.823268095041863 2.024824731758428 ELEEIVQPIISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELEEIVQPIISK 12 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 70618300.0 2907300.0 38700000.0 29011000.0 False True 3811498.4543332504 32926110.85141845 26009220.013162345 1.0 8.638626316110694 6.823883132785414 21.861926860384465 -9.822935116756364 7.656985936820634 0.9999999934638942 7.731254724448062 0.948305106021706 0.7408658022235242 8.270230432720856e-08 1.1168051941011239e-08 0.7173402231019524 0.2391134094821877 1.5033665510575707e-10 9.822935116756364 6.731254730984168 ELEEIVQPIISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELEEIVQPIISK 12 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 81470600.0 27184000.0 9777600.0 44509000.0 False True 26321058.799769316 13681846.6695104 32850757.658621464 1.0 0.5198060903853272 1.2480788827123237 24.649714188788213 -6.728831987871673 1.7271231240521892 0.7106581275662488 1.2475854585550032 0.5540449715674279 0.20188080372864609 0.338411686957307 1.9770281712131104 0.0926430917472798 0.2302242814838663 1.867101862310625e-07 6.728831987871673 0.5369273309887544 ELEEIVQPIISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELEEIVQPIISK 12 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 71143300.0 2907300.0 38696000.0 29540000.0 False True 3982207.3768283254 36986282.76944 22563260.39539693 1.0 9.287884650271064 5.666018431558352 21.925136921907356 -9.576802684016384 10.709205960889646 0.9999999912686751 7.476951540914708 0.8100296959653097 1.4786206920782803 0.0 0.0 1.431668318277456 0.4772227763147387 2.6497037231927005e-10 9.576802684016384 6.476951549646033 ELEEIVQPIISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELEEIVQPIISK 12 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 32189200.0 27184000.0 2966800.0 2038400.0 False True 22604700.455390133 2950817.2595363054 2464620.015503279 1.0 0.1305399850513249 0.1090313061377279 24.43011946422249 ELEEK(ub)VMELHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELEEKVMELHK 11 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6 P11171 EPB41 Protein 4.1 1 13671700.0 3422100.0 4948100.0 5301500.0 True False 4486406.239663546 4209862.767542732 4752951.63557892 1.0 0.9383596898390653 1.05941178343568 22.097128830277278 -6.768266166052693 1.58093369524528 0.964566667369232 1.0600509590237615 0.7239388968671223 0.025967121598888716 0.26924404700983506 1.3277706773211106 0.01294836046358082 0.030873728964783492 1.70503710265967e-07 6.768266166052693 0.09548429165452943 ELEEK(ub)VMELHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELEEKVMELHK 11 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6 P11171 EPB41 Protein 4.1 1 11963100.0 3632300.0 3631500.0 4699300.0 True False 3516994.6247204943 5081576.888022317 3468412.3540218864 1.0 1.4448634218274259 0.9861864245236176 21.74591169931298 -8.852009561170853 18.62187613147942 1.0000170922917546 1.2155249231755216 0.22743400362923716 0.1872541002844044 0.0 0.0 0.1813080028601454 0.06043600095338178 1.406016569758664e-09 8.852009561170853 0.21550783088376702 ELEEK(ub)VMELHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELEEKVMELHK 11 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6 P11171 EPB41 Protein 4.1 1 11766400.0 3422100.0 5729500.0 2614800.0 True False 4687342.848775229 5476351.745077175 1997238.09349641 1.0 1.1683275411586562 0.4260917449250111 22.16033889180017 -6.847096036825448 1.2488917778330868 1.089657580614931 0.39802159707591017 0.9359827241764292 0.08039299414331197 0.16068811893784543 0.4837408190421942 0.05040344851209545 0.11644967483652431 1.4220142981174776e-07 6.847096036825448 -0.6916359835390207 down ELEEK(ub)VMELHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELEEKVMELHK 11 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6 P11171 EPB41 Protein 4.1 1 10093400.0 3632300.0 5092400.0 1368700.0 True False 3020418.3881736845 5064966.23043774 1654888.841846221 1.0 1.6769088184171412 0.5479005320341929 21.526316974747257 -6.744327857506265 1.6707305218191235 1.4007272410202487 0.5465794630774405 0.6242418310178489 0.28439818822280855 0.31005068031367816 1.7008679556399346 0.1345735136438185 0.3286910413999754 1.8016571206996007e-07 6.744327857506265 -0.8541477779428082 ELEESK(ub)YQYSEPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELEESKYQYSEPR 13 1 Q01432-6;Q01432;Q01432-5;Q01432-4;E9PKC5;Q01432-3 Q01432-6 AMPD3 AMP deaminase 3 1 6506020.0 877720.0 2546900.0 3081400.0 True False 849857.2590396379 3563890.451908038 2274288.8999814955 1.0 4.193516515862125 2.6760833961123125 19.69686102278281 -10.038710054356489 14.894119639550027 1.0000006951138094 3.4347999378131835 0.7744080213738261 0.6194894770312376 0.0 2.8733127029064354e-17 0.5998180979851429 0.19993936897437437 9.147237296468987e-11 10.038710054356489 2.4347992426993743 ELEESK(ub)YQYSEPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELEESKYQYSEPR 13 1 Q01432-6;Q01432;Q01432-5;Q01432-4;E9PKC5;Q01432-3 Q01432-6 AMPD3 AMP deaminase 3 1 18960300.0 4111600.0 6004600.0 8844100.0 True False 6237597.798223533 4933032.215846061 7096059.7584932735 1.0 0.7908544884460149 1.1376270141230058 22.572559099718923 -6.743401787013591 1.674149513645174 0.8760512876593438 1.137988229780936 0.6201292849357216 0.08787070964169229 0.311708233229522 1.7166406164207784 0.04150008725682211 0.10146333280164552 1.8055029942004262e-07 6.743401787013591 0.26193694212159224 ELEESK(ub)YQYSEPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELEESKYQYSEPR 13 1 Q01432-6;Q01432;Q01432-5;Q01432-4;E9PKC5;Q01432-3 Q01432-6 AMPD3 AMP deaminase 3 1 6142520.0 877720.0 2329200.0 2935600.0 True False 729863.0695889135 2316652.1372899995 3549420.387319181 1.0 3.1740914615598044 4.863131915029417 19.477266298217085 -7.759922347979341 0.23212846779893928 5.696217823187163e-13 6.725449221635637 0.9997975122696144 0.022500977257173305 0.13164718647875767 0.03380746044771533 0.28676920955641094 0.5049366044711494 1.73811157598701e-08 7.759922347979341 6.725449221635068 ELEFYLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELEFYLR 7 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 57441000.0 18478000.0 19923000.0 19040000.0 False True 24224836.941206563 16950566.05924573 17069923.444576547 1.0 0.6997184790297902 0.7046455456441287 24.529983619019927 -10.184952847132058 5.685928174974839 1.0000069127528501 0.70218201233704 0.999794765334265 0.0020114665223511363 1.7627027275554607e-07 2.5268904328740884e-08 0.0019476392709749865 0.0006491980285366311 6.532014691612886e-11 10.184952847132058 -0.2978249004158101 ELEFYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELEFYLR 7 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 145377000.0 29591000.0 81606000.0 34180000.0 False True 44891710.391874775 67042771.70941179 27424308.01837378 1.0 1.493433222396139 0.6108991566366666 25.41994572876233 -6.754983898366115 1.6314696506108597 1.2883944107553431 0.6084627488030341 0.6701222258225117 0.2074157018588293 0.29142240305299355 1.5275573844787298 0.1003715200374865 0.2424070522271559 1.7579887908567038e-07 6.754983898366115 -0.679931661952309 ELEFYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELEFYLR 7 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 34852000.0 18732000.0 9084300.0 7035700.0 False True 15576487.96830369 9035361.07280762 8506832.340598704 1.0 0.5800640742119475 0.5461328868169193 23.892866649737332 -13.999999999999998 0.35655302312405535 6.378002204688867 0.5418437178240207 0.9997669926307914 0.0031509498276096376 21.329919661590655 0.19270834330904119 87.15070658915535 0.00990314910733853 1.0000000000000041e-14 13.999999999999998 -5.836158486864846 ELEFYLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELEFYLR 7 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 105094000.0 29591000.0 50928000.0 24575000.0 False True 38306132.825813554 48093812.03069006 20102602.160793755 1.0 1.2555120677251146 0.5247880868633941 25.19107205085478 -6.812246733579377 1.4051933677196162 1.1388837078958238 0.5113505510052219 0.8655906086783833 0.1110041033393623 0.2037476113645006 0.7925080053407765 0.06210915021284818 0.14352211492099498 1.5408248230416283e-07 6.812246733579377 -0.627533156890602 ELEGK(ub)TGFSSDQIEQLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELEGKTGFSSDQIEQLHR 18 1 Q96BS2-3;Q96BS2;E9PQ58;Q96BS2-2 Q96BS2-3 TESC Calcineurin B homologous protein 3 1 20509500.0 2791200.0 3074300.0 14644000.0 True False 3613263.422777559 2903212.5024731057 11978942.260128736 1.0 0.8034876406108723 3.315269566180807 21.784871006735344 -6.887989368563251 1.034168776224502 0.858462878372667 3.5230111328590774 0.9795811416286075 0.16298153470100052 0.1207910768104817 0.23148089786482304 0.12038229087941296 0.29803237537359917 1.294227523477307e-07 6.887989368563251 2.6645482544864105 up ELEK(ub)TYSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELEKTYSAK 9 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 13220300.0 4158200.0 5637800.0 3424300.0 True False 5451440.468066077 4796662.215972283 3069986.284205015 1.0 0.8798889475305819 0.5631513913044907 22.378206061883322 -6.954308329530614 0.5093574784112452 1.0058602317669174 0.4232996289813918 0.9994974351729975 0.0041308662152038066 0.08180053079037634 0.02914960048414485 0.0047632425756878915 0.02613999472558277 1.1109427279145157e-07 6.954308329530614 -0.5825606027855257 ELEK(ub)TYSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELEKTYSAK 9 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 14866600.0 6632200.0 5444800.0 2789600.0 True False 6421664.441282744 7618937.034256898 2058920.0737938494 1.0 1.1864427211856925 0.32062093754973203 22.614515849531823 -6.850367138074073 1.2334197752566094 1.0995203180084339 0.2857828918219597 0.9408221103202911 0.0905130618634805 0.15705657992168282 0.45962080090054835 0.057419108598586725 0.13289451785401504 1.4113439370706686e-07 6.850367138074073 -0.8137374261864742 down ELEK(ub)TYSAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELEKTYSAK 9 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 15974900.0 6052500.0 5121300.0 4801100.0 True False 9182084.997020116 4207364.002100471 3852160.480603119 1.0 0.45821444731407923 0.41953003940317146 23.130390356222183 -13.999999999999998 0.37469149657640405 8.772953678101356 0.41581088810628786 0.9997988218769156 0.0037585300214174615 23.378016943527708 0.19911578225115595 146.2520089936142 0.01065536758510454 1.0000000000000041e-14 13.999999999999998 -8.357142789995068 ELEK(ub)TYSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELEKTYSAK 9 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 11834500.0 4158200.0 4650100.0 3026200.0 True False 5695598.911129751 4444643.206175648 2311473.886545367 1.0 0.780364501701548 0.40583508821671477 22.441416123406214 -6.963038915992951 0.39024930886234627 1.0229384339021417 0.14979856739518832 0.9998668379585253 0.002830641887199608 0.07863289698117007 0.017246787466902162 0.004834923326234471 0.03150140867412894 1.0888325215266948e-07 6.963038915992951 -0.8731398665069534 down ELEK(ub)TYSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELEKTYSAK 9 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 15695600.0 6632200.0 7578600.0 1484800.0 True False 5514968.156277166 7537772.5775656765 1795264.815060472 1.0 1.3667844244913987 0.325525871444442 22.3949211249661 -6.811493982957083 1.4081247977072335 1.1995410354498126 0.3066575982246287 0.8637345849292386 0.15918637889285567 0.20476051201938905 0.7998898460963422 0.088881565361207 0.20547717735133156 1.5434978079577776e-07 6.811493982957083 -0.8928834372251839 down ELEK(ub)TYSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELEKTYSAK 9 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 12582400.0 6052500.0 4165000.0 2364900.0 True False 7835080.562611493 3933214.0886707515 1934512.46592314 1.0 0.5020004653736171 0.24690396613846075 22.901516678314632 -9.374988180547271 0.20046163216616025 1.4716396885744771 1.1755242185360152e-19 0.9995067644305647 0.006945511214674963 0.7964114268071426 0.07608627173805194 0.37333164610621705 0.14220789918059282 4.2170798017977275e-10 9.374988180547271 -1.4716396885744771 ELEK(ub)VCNPIITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELEKVCNPIITK 12 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 341213000.0 141798000.0 109683000.0 89732000.0 True False 185898551.17378545 93318723.94098541 80447393.41012305 1.0 0.5019873654300152 0.43274889934412447 27.469940285555648 -13.999999999999998 0.27798008243151184 5.01394761112696 0.41148683674685704 0.999600716473563 0.005048891735869191 15.290113155729411 0.166990317863496 34.84949088218961 0.02765428738642667 1.0000000000000041e-14 13.999999999999998 -4.602460774380103 ELEK(ub)VCNPIITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELEKVCNPIITK 12 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 190451400.0 94590000.0 68503000.0 27358400.0 True False 91587292.22594826 95856605.13842566 20192414.30559284 1.0 1.0466146864779549 0.22047179051628277 26.448644101895844 -6.893535016580958 1.001220225599255 1.0407013983220446 0.1442881035850873 0.9830666636225368 0.0493105624843158 0.11632242907102687 0.2054610445329078 0.0373407056736064 0.09435882910029607 1.2778061776162615e-07 6.893535016580958 -0.8964132947369572 down ELEK(ub)VCNPIITK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELEKVCNPIITK 12 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 557228000.0 283008000.0 181292000.0 92928000.0 True False 429343826.6562032 148939026.1591388 74560740.06821078 1.0 0.34689919107280337 0.17366207556517457 28.67755820715211 -13.999999999999845 0.1862780959714629 4.457183615539967 0.044616191722848655 0.9994918929673067 0.008020320067352581 12.292461538029665 0.1368599440879566 15.406980854829442 0.12276076594674083 1.0000000000003558e-14 13.999999999999845 -4.412567423817118 ELEK(ub)VCNPIITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELEKVCNPIITK 12 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 371937000.0 141798000.0 127232000.0 102907000.0 True False 194224552.54686588 121610469.54004 78602486.036192 1.0 0.6261333489786041 0.404699019796817 27.53315034707854 -9.206408637012723 0.14038941980750996 1.5595798511281802 8.3685137217092e-07 0.9998586041319926 0.002921280202836058 0.6509463805262211 0.04941883575743318 0.33382401096400866 0.18576253324673367 6.217150248403482e-10 9.206408637012723 -1.559579014276808 ELEK(ub)VCNPIITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELEKVCNPIITK 12 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 192273200.0 94590000.0 44972200.0 52711000.0 True False 78655776.04750408 44729925.83231724 63732626.39187274 1.0 0.5686794801350971 0.8102726791911821 26.22904937733012 -10.137926298600071 5.356415259485289 1.0000074898019071 0.6894760796630119 0.6877654744875332 0.09863001050279059 8.82194362208009e-06 1.4198026362647941e-06 0.0955003987001437 0.03183269900939946 7.279033219754399e-11 10.137926298600071 -0.3105314101388952 ELEK(ub)VCNPIITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELEKVCNPIITK 12 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 536756000.0 283008000.0 191776000.0 61972000.0 True False 366359434.9216942 181103497.01534733 50693731.88641756 1.0 0.49433283205619216 0.1383715746183877 28.44868452924456 -8.190823414316155 0.3512172895248967 1.1016792274884522 2.243154819481051e-19 0.998206468690995 0.014971765594285686 0.0960486394844498 0.08379799635152274 0.06926637122103455 0.08770076136935659 6.444312402902065e-09 8.190823414316155 -1.1016792274884522 ELELLK(ub)HNPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELELLKHNPK 10 1 Q9UPT9;Q9UPT9-2;K7ESK0;K7ERX6 Q9UPT9 USP22 Ubiquitin carboxyl-terminal hydrolase 22 1 9892900.0 4282900.0 2663600.0 2946400.0 True False 3561421.1146406103 2649250.658116798 3562478.6173856277 1.0 0.7438745862504212 1.0002969328004123 21.764021604318447 -10.963193909681584 9.620853703202071 1.0565995379893276 0.8720857595254442 0.24913151310624837 0.1046839846157661 0.07164437576384591 0.000274086639202426 0.057139917701252874 0.03378661075262462 1.0884440016053347e-11 10.963193909681584 -0.1845137784638834 ELELLK(ub)HNPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELELLKHNPK 10 1 Q9UPT9;Q9UPT9-2;K7ESK0;K7ERX6 Q9UPT9 USP22 Ubiquitin carboxyl-terminal hydrolase 22 1 15412100.0 1824400.0 3778400.0 9809300.0 True False 2361721.7643004386 3568128.7185194623 8024108.05191757 1.0 1.510816715353585 3.3975670518048413 21.171407579398725 -6.946707308368435 0.5938938956447716 0.9784303574425609 4.025529235842669 0.9989169015328919 0.03393501074398073 0.08483548985736541 0.04164646380866798 0.03504200669550047 0.15825029633402973 1.130557594315283e-07 6.946707308368435 3.047098878400108 ELELQFDLGNLLASDRNPPTGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELELQFDLGNLLASDRNPPTGLR 23 1 Q15050 Q15050 RRS1 Ribosome biogenesis regulatory protein homolog 0 38842000.0 10542000.0 15174000.0 13126000.0 False True 15992984.723434288 12466081.14499686 10531640.346669817 1.0 0.779471834718287 0.6585162512684676 23.930935874065415 -13.999999999750735 0.07249673144961574 2.251452834678166 0.24123679194201952 0.9999156964542781 0.0012980208170394788 12.334536495412106 0.073503604211157 2.5723933101242875 0.3828761578177344 1.000000000573955e-14 13.999999999750735 -2.010216042736147 ELENANDLLSATK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELENANDLLSATKR 14 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 40359040.0 15748440.0 18976000.0 5634600.0 True False 20646357.34810991 16144854.76786868 5051585.642899745 1.0 0.7819711000665538 0.24467200473802694 24.299383932568954 -6.969835147224025 0.4960001842898761 1.0110746026185269 5.744107609690735e-20 0.9995823245556957 0.006486959408473141 0.07899146133847242 0.027052099382300264 0.007732919568616258 0.042996968526643455 1.071926117825176e-07 6.969835147224025 -1.0110746026185269 down ELENANDLLSATK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELENANDLLSATKR 14 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 65546700.0 27101000.0 29992000.0 8453700.0 True False 26240693.589337405 41967962.00621378 6239422.364436146 1.0 1.5993465212088358 0.2377765794640223 24.645302517729768 -6.787021522663689 1.5080373418312187 1.3362616463943806 0.22441434071581567 0.7916327329410333 0.25433867605676963 0.23979087730159984 1.0773157454582378 0.13277216243796636 0.3115632093200204 1.6329710194956973e-07 6.787021522663689 -1.111847305678565 ELENANDLLSATK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELENANDLLSATKR 14 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 130098000.0 69255300.0 26380000.0 34462700.0 True False 105065353.34062415 21672282.892119255 27651132.239462018 1.0 0.20627430644864672 0.2631803097812506 26.646711759471422 -10.235938515611252 8.174847795016808 1.0000004342400495 0.23472730811495213 0.9958700224841025 0.023231778577666434 1.8383721320698908e-07 1.722099743956905e-08 0.022494085283955176 0.007498024294506695 5.808466439240552e-11 10.235938515611252 -0.7652731261250973 ELENANDLLSATK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELENANDLLSATKR 14 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 44316740.0 15748440.0 22129000.0 6439300.0 True False 21571063.85358865 21151267.60918279 4918469.961546358 1.0 0.9805389179108095 0.22801239637182297 24.362593994091846 -6.9124521407914585 0.8788699101687864 1.0215325733082683 0.12548230675384267 0.9918143172278314 0.032518370794165 0.10281933666119168 0.1301375691521388 0.026950161823063482 0.075721408208075 1.2233419237799112e-07 6.9124521407914585 -0.8960502665544257 down ELENANDLLSATK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELENANDLLSATKR 14 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 65323800.0 27101000.0 31397600.0 6825200.0 True False 22535682.277866684 31228454.896864377 8252317.763840748 1.0 1.3857337227164965 0.36618894702583393 24.425707793164044 -6.804190784205027 1.438686300562295 1.2117103402862774 0.3506065274255055 0.84414297192337 0.16593483469807505 0.21483283892452215 0.8773793952712604 0.09071666150558814 0.21046369925041813 1.5696731003778653e-07 6.804190784205027 -0.861103812860772 down ELENANDLLSATK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELENANDLLSATKR 14 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 134699100.0 69255300.0 30874800.0 34569000.0 True False 89652351.07605587 29156590.238869563 28277796.707893364 1.0 0.3252183561157788 0.3154161198059839 26.417838081563872 ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK(ub)GGSGSGPTIEEVD ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD 44 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 139330000.0 99332000.0 14932000.0 25066000.0 True False 96178760.0315879 20894425.4693513 18500462.63611867 1.0 0.21724573557081586 0.19235497140993063 26.51921499084301 ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK(ub)GGSGSGPTIEEVD ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD 44 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 502522000.0 66800000.0 292002000.0 143720000.0 True False 101340483.73415004 239891961.67796093 115313679.00528637 1.0 2.367187848710864 1.1378836448796978 26.59463537958466 -6.620680586985213 2.1139553280137937 1.906719029448348 1.1425654349927947 0.08515634673841754 0.5878324184192374 0.5836003797384188 4.956589436360204 0.22839514794614774 0.6518598083340252 2.395076629318465e-07 6.620680586985213 -0.7641535944555533 ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK(ub)GGSGSGPTIEEVD ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD 44 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 167231000.0 99332000.0 25146000.0 42753000.0 True False 82598959.15372324 25010533.506909773 51692454.632462546 1.0 0.30279477808386396 0.6258245280822338 26.299620266277287 -10.549028791786617 6.412600206920293 1.0006870933692018 0.4643096530836908 0.7857181251782439 0.13187634320580352 0.0012969715404212033 9.121067667147969e-05 0.12783928477574022 0.04256290674956756 2.8246927041837848e-11 10.549028791786617 -0.536377440285511 ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK(ub)GGSGSGPTIEEVD ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD 44 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 370790000.0 66800000.0 178890000.0 125100000.0 True False 86473916.82485703 168934614.24305174 102333083.6343969 1.0 1.9535904055925832 1.1833982707370685 26.36576170167711 -10.121587301237525 4.427256056963696 0.9999342741426118 1.568494337617636 0.42076951942445273 0.3144296225087333 219337992.9858542 23.76307770085358 164144.88557493966 0.107637623103462 7.558101132308366e-11 10.121587301237525 0.5685600634750241 ELESQISELQEDLESER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELESQISELQEDLESER 17 0 P35579 P35579 MYH9 Myosin-9 0 14204300.0 3897800.0 2189600.0 8116900.0 False True 3774066.472547849 3063918.698613154 5990840.388219575 1.0 0.8118348526449565 1.5873701302815675 21.847688402641598 -6.84259302138161 1.2702584163921993 0.8999093199538547 1.614222630755489 0.9288300442166089 0.08811562557809433 0.16578906546431346 0.518509907268925 0.054368629457528114 0.12535841278120466 1.4368352651573417e-07 6.84259302138161 0.7143133108016343 ELEVLLMCNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELEVLLMCNK 10 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 34450000.0 12398000.0 12044000.0 10008000.0 False True 16253898.06240279 10247082.14714429 8972468.163514817 1.0 0.630438440539197 0.5520194681341831 23.954282415638467 -13.999999999999998 0.2178845245947444 3.209635071582687 0.5092131574399466 0.999495863140228 0.004385915158121828 12.94289169567443 0.14788947361229998 12.291543769209284 0.04401244029892684 1.0000000000000041e-14 13.999999999999998 -2.7004219141427406 ELEVLLMCNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELEVLLMCNK 10 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 15576900.0 9758800.0 3036400.0 2781700.0 False True 9449012.235697053 4248850.354616815 2053089.3207887723 1.0 0.44966079507922 0.2172808405340493 23.17173209261099 -10.524880065322936 0.18662973758663357 1.8146274700245966 6.419296698063865e-21 0.9994696394204144 0.007558633492826959 2.290540381810224 0.09633312282110183 1.0130060767467142 0.15499479012793022 2.986207175432993e-11 10.524880065322936 -1.8146274700245966 ELEVLLMCNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELEVLLMCNK 10 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 96317000.0 11376000.0 58826000.0 26115000.0 False True 17258223.697001368 48328040.69036416 20953358.80338889 1.0 2.8002905477903384 1.2141086574877087 24.040780646955298 -6.615657043153461 2.1330577922968064 2.1981645167414112 1.2200403226107084 0.06834100762297346 0.7750475366410099 0.5971139108033979 5.156459298539179 0.29921876139565085 0.8596448273155449 2.42294165776445e-07 6.615657043153461 -0.9781241941307028 ELEVLLMCNK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ELEVLLMCNK 10 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 50644100.0 14695200.0 15891900.0 20057000.0 False True 20128412.562847886 15189743.310514368 15319949.68688141 1.0 0.7546418905657225 0.7611106757200655 24.262730062103522 -10.177003847654273 5.225149480165686 1.000012127168575 0.7578762831427748 0.999464940974642 0.002640870481055222 3.731038569941367e-07 5.8765832342824784e-08 0.0025571398597224932 0.0008523372826581262 6.652672622061466e-11 10.177003847654273 -0.24213584402580013 ELEVLLMCNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELEVLLMCNK 10 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 34601000.0 11376000.0 23225000.0 0.0 False True 14726456.25448464 21932508.333584215 0.0 1.0 1.4893269605785249 0.0 23.811906969047747 -6.839613963897575 1.430234325832002 1.262702566479382 7.026915653635223e-23 0.8794270816349029 0.21522215029592617 0.18474835304580337 0.7587456680363966 0.12067437002702494 0.25828851145427034 1.4467251658553602e-07 6.839613963897575 -1.262702566479382 down ELEVMTAK(ub)YEGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELEVMTAKYEGAK 13 1 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4;H0YFY6;K4DIE0 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 1 12297700.0 4091700.0 5633900.0 2572100.0 True False 5364258.324079164 4793344.080770194 2305963.765325389 1.0 0.8935707028227478 0.4298755999453538 22.35494728342977 -6.942916843845392 0.631847680418037 1.0050589250730149 0.2933175782834366 0.9985215055122342 0.009517324596225873 0.08646086392898016 0.04873707695436404 0.009483639396307244 0.039425226803490546 1.1404681367915387e-07 6.942916843845392 -0.7117413467895783 down ELEVMTAK(ub)YEGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELEVMTAKYEGAK 13 1 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4;H0YFY6;K4DIE0 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 1 17006000.0 7571100.0 5886900.0 3548000.0 True False 7330759.574710607 8237569.869777947 2618672.3622815437 1.0 1.12369936373246 0.3572170571949115 22.805531259892525 -6.865537136529105 1.1573605665697344 1.0683939598619372 0.3159614826547837 0.9600270134390966 0.06717408377267306 0.14121034069405147 0.35631827409201516 0.04515376169292325 0.1061562080405786 1.3628964599237003e-07 6.865537136529105 -0.7524324772071536 down ELEVMTAK(ub)YEGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELEVMTAKYEGAK 13 1 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4;H0YFY6;K4DIE0 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 1 25164500.0 11317500.0 8001900.0 5845100.0 True False 17169474.920078512 6573898.425869943 4689813.423001663 1.0 0.38288290448429635 0.2731483312583573 24.033342583471086 -13.999999999999993 0.24291685011516706 5.143222838922988 0.2259543716470448 0.9995298977777228 0.006936637652843759 13.728211508105094 0.15597982608493977 27.638498276090804 0.052716697828774424 1.0000000000000164e-14 13.999999999999993 -4.917268467275943 ELEVMTAK(ub)YEGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELEVMTAKYEGAK 13 1 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4;H0YFY6;K4DIE0 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 1 34336800.0 11317500.0 17710100.0 5309200.0 True False 14650726.851277256 16724517.36657093 4342980.07699232 1.0 1.141548643718853 0.2964344445896005 23.804468905563535 -6.863831799273018 1.1661276182669065 1.0777380790346383 0.25239220019408276 0.9581355082866051 0.07561766606447672 0.14291187550282325 0.36711621607742734 0.050488794389675185 0.11841994268530766 1.3682586447565235e-07 6.863831799273018 -0.8253458788405554 down ELEVQHPAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELEVQHPAAK 10 0 P50990;P50990-2;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 5454880.0 1416700.0 478080.0 3560100.0 False True 1371727.6339623742 668979.8371542651 2627603.009289319 1.0 0.48769144879136767 1.9155428120225455 20.387562622161575 -6.80968279149794 1.4160289886405628 0.7206994109682937 1.940305244939816 0.8589697536914929 0.22179964518914544 0.20722590992258566 0.8190336990422767 0.1231702427822882 0.28493767859234953 1.54994828713686e-07 6.80968279149794 1.2196058339715221 ELFDQCENK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELFDQCENKR 10 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 8486400.0 3853600.0 2444900.0 2187900.0 True False 5052106.918315487 2080130.450145558 1961517.095818753 1.0 0.4117352391344741 0.3882572414902053 22.268453740692575 ELFDQCENK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELFDQCENKR 10 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 8467100.0 2988400.0 2656800.0 2821900.0 True False 2893534.8777674604 3717674.09502897 2082759.7348146227 1.0 1.2848209031775637 0.7197976947910852 21.464401603333467 -6.769628906753856 1.5756665079976926 1.1634377451113511 0.7166470109803432 0.729250385404637 0.12002712986187192 0.2670104151356906 1.3081929641252468 0.06004324479646108 0.14298864145935367 1.6996953772712516e-07 6.769628906753856 -0.4467907341310079 ELFDQCENK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELFDQCENKR 10 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 32966000.0 13684000.0 10899000.0 8383000.0 True False 20759628.43440285 8953988.295724327 6726096.375600581 1.0 0.4313173679392922 0.32399888065694354 24.307277286103783 -13.999999999999998 0.23448407448095201 4.666034426421529 0.2739971616643874 0.9995162347434474 0.006524235555688406 13.43508963451078 0.15329293587420148 22.989560942680583 0.05419490604458816 1.0000000000000041e-14 13.999999999999998 -4.392037264757142 ELFDQCENK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELFDQCENKR 10 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 8487100.0 3853600.0 2125900.0 2507600.0 True False 5278380.059624269 2031970.7085888078 1915356.5256431065 1.0 0.38496104593374997 0.3628682482139127 22.331663802215466 ELFDQCENK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELFDQCENKR 10 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 7878700.0 2988400.0 1939300.0 2951000.0 True False 2484987.0085670943 1928852.605979091 3568040.4561176277 1.0 0.7762022897219554 1.4358386759434405 21.244806878767744 -6.815152998953811 1.3925930310316212 0.8787497736927741 1.4488096624919804 0.8728924672547734 0.09764905391736192 0.1998587354161609 0.7628361637630816 0.05511821491059004 0.12723908578219195 1.5305481651188404e-07 6.815152998953811 0.5700598887992063 ELFDQCENK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELFDQCENKR 10 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 32001400.0 13684000.0 12547000.0 5770400.0 True False 17714207.751966238 11848748.420300588 4720246.409303944 1.0 0.6688839030345799 0.2664666958520912 24.078403608196233 -7.287943465759525 0.34992787480261445 1.0494316914384705 2.908056841006738e-24 0.9997371545581317 0.004862694047334353 0.1015400244810498 0.025440766230098177 0.011692486106039447 0.04936954915055492 5.152957187843076e-08 7.287943465759525 -1.0494316914384705 down ELFESWCTDK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELFESWCTDKR 11 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 5623500.0 1309700.0 1821000.0 2492800.0 True False 1717029.3831528397 1549313.8982024058 2234868.968626075 1.0 0.9023222976869086 1.3015904040747217 20.711483297403984 -6.8420260584367805 1.2729671959243394 0.9480442998226685 1.3152570707396853 0.9278807987860834 0.04563709251135894 0.16644462367266535 0.5230470358197213 0.028102143409137928 0.06478080102022653 1.4387122503871811e-07 6.8420260584367805 0.3672127709170169 ELFESWCTDK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELFESWCTDKR 11 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 33297000.0 3402400.0 9014600.0 20880000.0 True False 5161689.548758574 7405874.198608731 16753058.84797091 1.0 1.4347771458649428 3.2456541002161106 22.299411942074286 -6.943946357667502 0.6217656023658169 0.9802024788838489 3.7964569800013406 0.9986364576197351 0.03590957081450368 0.08601149708085927 0.046751140059433885 0.0361056359463534 0.15335779259426593 1.137767809713567e-07 6.943946357667502 2.8162545011174918 up ELFESWCTDK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELFESWCTDKR 11 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 21747800.0 3402400.0 4277400.0 14068000.0 True False 4404473.87133075 4039358.9298632154 11507768.349869665 1.0 0.9171036196073016 2.6127452871897168 22.070538264166736 -6.8954094889508655 0.9898540844010795 0.9203504708335517 2.775018087283379 0.9841400922216432 0.09829670993241321 0.11486287539117777 0.19709730610123183 0.07507606290917192 0.19119917742147063 1.2723028823274734e-07 6.8954094889508655 1.8546676164498272 up ELFPVLQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELFPVLQKR 9 1 Q6PJG6 Q6PJG6 BRAT1 BRCA1-associated ATM activator 1 1 4265700.0 1279200.0 1683700.0 1302800.0 True False 1677043.5877904226 1432498.523011196 1167998.753340039 1.0 0.8541808534020124 0.6964629672380357 20.67748875558593 -6.970123364575903 0.25522211223368846 1.0469440547262407 0.49904942331430374 0.9999833270020508 0.0005060877766976161 0.07626269690481231 0.008886790783642058 0.0033968373697503412 0.014990158185550908 1.071214975439456e-07 6.970123364575903 -0.5478946314119371 ELFPVLQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELFPVLQKR 9 1 Q6PJG6 Q6PJG6 BRAT1 BRCA1-associated ATM activator 1 1 93425400.0 3999400.0 15188000.0 74238000.0 True False 6067382.195304789 12477582.735614387 59564826.76032864 1.0 2.0565018543368008 9.81722015244442 22.532642761509894 -6.9317195293432805 0.7325388714285117 0.8891888031124038 11.482548391522563 0.9968655569685133 0.2200920015194786 0.0917547399100702 0.07337753647548442 0.2026056804851841 0.6956901997034846 1.1702549064925774e-07 6.9317195293432805 10.59335958841016 ELFPVLQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELFPVLQKR 9 1 Q6PJG6 Q6PJG6 BRAT1 BRCA1-associated ATM activator 1 1 5497210.0 1279200.0 1368600.0 2849410.0 True False 1752154.8090801763 1308130.726645017 2176438.0434410265 1.0 0.746583988963705 1.2421493992209427 20.74069881710882 -6.767665922803439 1.5831441186828763 0.8542199635783018 1.2447120869616621 0.7216846840486029 0.1067410136419655 0.2701976529665683 1.3360923571236585 0.05315393184288645 0.12681382866466648 1.707395282721993e-07 6.767665922803439 0.39049212338336037 ELFPVLQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELFPVLQKR 9 1 Q6PJG6 Q6PJG6 BRAT1 BRCA1-associated ATM activator 1 1 97028400.0 3999400.0 11390000.0 81639000.0 True False 5177302.139960081 10756136.48738531 66781539.68687862 1.0 2.0775562632062736 12.898907168549666 22.303769083602344 -6.926127775930559 0.777929065156208 0.809683433299528 14.916138037306764 0.9957207206642378 0.35149788171497864 0.09469908732555063 0.08790271074253782 0.3131391280255068 1.0008031638351238 1.1854199285871944e-07 6.926127775930559 14.106454604007236 ELFSPLHALNFGIGGDGTQHVLWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELFSPLHALNFGIGGDGTQHVLWR 24 0 M0R389;Q15102;M0QZT2;M0QXS6;M0R323;M0R1K3 M0R389 PAFAH1B3 Platelet-activating factor acetylhydrolase IB subunit gamma 0 20897400.0 13026000.0 2364600.0 5506800.0 False True 12612496.76007191 3308797.1112260995 4064403.8795411456 1.0 0.26234275212667996 0.3222521247662919 23.588350562940292 -10.37172428206357 5.0957308989512295 1.0004449659497339 0.2922974384464177 0.9946540933572752 0.024457898963121442 0.0001237129276116167 1.525306984807305e-05 0.023695492900808007 0.00789375294724869 4.2488922521559023e-11 10.37172428206357 -0.7081475275033162 ELFSPLHALNFGIGGDGTQHVLWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELFSPLHALNFGIGGDGTQHVLWR 24 0 M0R389;Q15102;M0QZT2;M0QXS6;M0R323;M0R1K3 M0R389 PAFAH1B3 Platelet-activating factor acetylhydrolase IB subunit gamma 0 197954000.0 53687000.0 52989000.0 91278000.0 False True 81447104.04543896 43532698.94505332 73236863.29143135 1.0 0.5344904457347757 0.899195424438576 26.27936006703158 -9.849027273988762 6.406901995941714 1.0000000119634918 0.7168429350866304 0.4455932850788421 0.14889018407965066 2.5519042675271826e-08 4.3588018350341504e-09 0.1441623072830408 0.04805410027949607 1.415704869936866e-10 9.849027273988762 -0.2831570768768613 ELFSPLHALNFGIGGDGTQHVLWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELFSPLHALNFGIGGDGTQHVLWR 24 0 M0R389;Q15102;M0QZT2;M0QXS6;M0R323;M0R1K3 M0R389 PAFAH1B3 Platelet-activating factor acetylhydrolase IB subunit gamma 0 27896700.0 13026000.0 5660200.0 9210500.0 False True 10831696.1496436 5629707.379138271 11136372.965459658 1.0 0.5197438426412568 1.028128264641737 23.368755838374568 -10.097861027211248 13.400731347398203 0.9999971142847863 0.7739360536414969 0.20863748988714204 0.2075470711868422 0.0 0.0 0.2009565875621697 0.06698552918738988 7.982500837727821e-11 10.097861027211248 -0.22606106064328946 ELFSPLHALNFGIGGDGTQHVLWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELFSPLHALNFGIGGDGTQHVLWR 24 0 M0R389;Q15102;M0QZT2;M0QXS6;M0R323;M0R1K3 M0R389 PAFAH1B3 Platelet-activating factor acetylhydrolase IB subunit gamma 0 114605000.0 53687000.0 36628000.0 24290000.0 False True 69498879.82898365 34589619.601400346 19869469.236446835 1.0 0.4977003900856424 0.2858962516423253 26.05048638912403 -12.32152681309416 0.1396317992304698 2.5286336601858843 2.6096630748287187e-07 0.9996470738468344 0.005625832746825377 6.286973758992236 0.10001547457813963 2.9723962281163647 0.22791802379994888 4.769503665659898e-13 12.32152681309416 -2.5286333992195766 ELFSPLHALNFGIGGDTTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELFSPLHALNFGIGGDTTR 19 0 P68402;P68402-3;P68402-2;P68402-4 P68402 PAFAH1B2 Platelet-activating factor acetylhydrolase IB subunit beta 0 21198300.0 8252000.0 7374500.0 5571800.0 False True 10818451.912481671 6274253.345575858 4995283.584479605 1.0 0.579958518680201 0.46173737470851545 23.366990732879444 -13.999999999999998 0.17784129777655455 3.165256497802093 0.3657052065259921 0.99950090051516 0.005160062426254699 12.177541843229651 0.13366388197220228 9.106907673350788 0.08991439818856337 1.0000000000000041e-14 13.999999999999998 -2.799551291276101 ELFSPLHALNFGIGGDTTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELFSPLHALNFGIGGDTTR 19 0 P68402;P68402-3;P68402-2;P68402-4 P68402 PAFAH1B2 Platelet-activating factor acetylhydrolase IB subunit beta 0 65842000.0 30171000.0 17057000.0 18614000.0 False True 29213238.119770408 23867949.05107992 13738434.991969721 1.0 0.8170251087272316 0.4702811422562592 24.800118945706732 -6.96108533779256 0.41985757995910566 1.0153502218756632 0.25887902239046634 0.9998083579143607 0.0030410597297763514 0.07931566588305426 0.019715445657161452 0.004485024134649384 0.02886492510380419 1.0937414276674125e-07 6.96108533779256 -0.7564711994851968 down ELFSPLHALNFGIGGDTTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELFSPLHALNFGIGGDTTR 19 0 P68402;P68402-3;P68402-2;P68402-4 P68402 PAFAH1B2 Platelet-activating factor acetylhydrolase IB subunit beta 0 75529000.0 23225000.0 27469000.0 24835000.0 False True 35234022.97493471 22566942.333723396 19926351.364432815 1.0 0.6404872458015195 0.5655428952466856 25.070465873493262 -13.999999999999998 0.2203958172584741 3.1732266521366785 0.5256067237498695 0.9994982913775439 0.0042473804858081795 13.010452096199138 0.14872024262770592 12.308374439430672 0.04136811939404804 1.0000000000000041e-14 13.999999999999998 -2.647619928386809 ELFSPLHALNFGIGGDTTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELFSPLHALNFGIGGDTTR 19 0 P68402;P68402-3;P68402-2;P68402-4 P68402 PAFAH1B2 Platelet-activating factor acetylhydrolase IB subunit beta 0 55430000.0 8252000.0 21195000.0 25983000.0 False True 11302987.401914947 20258534.81750778 19846350.536682393 1.0 1.7923168536908738 1.7558500094691811 23.430200794402335 -10.097165162171608 5.0921022018869975 0.9999804360048005 1.77408343158193 0.9983382722615689 0.014887526818736247 3.306672823537205e-06 5.86280489779899e-07 0.01441514959390731 0.004804928618648921 7.995301359083297e-11 10.097165162171608 0.7741029955771296 ELFSPLHALNFGIGGDTTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELFSPLHALNFGIGGDTTR 19 0 P68402;P68402-3;P68402-2;P68402-4 P68402 PAFAH1B2 Platelet-activating factor acetylhydrolase IB subunit beta 0 61973000.0 30171000.0 14578000.0 17224000.0 False True 25088523.301926672 14499465.420493545 20825458.765221994 1.0 0.577932198160904 0.8300790969081351 24.580524221141008 -10.27724466818231 5.777957070722013 1.0000197348643232 0.7040056475345173 0.6475618399057927 0.10293854035933023 2.6170898584531245e-05 3.27364941777202e-06 0.09967645124794602 0.03322327104121427 5.2814762578322155e-11 10.27724466818231 -0.29601408732980583 ELFSPLHALNFGIGGDTTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELFSPLHALNFGIGGDTTR 19 0 P68402;P68402-3;P68402-2;P68402-4 P68402 PAFAH1B2 Platelet-activating factor acetylhydrolase IB subunit beta 0 67720000.0 23225000.0 26490000.0 18005000.0 False True 30065220.33319323 25015808.213418514 14728274.746900996 1.0 0.8320513848288695 0.4898774924539761 24.84159219558571 -6.959681313671274 0.43990532071766864 1.0122467691657615 0.2963434170203299 0.9997581873481766 0.0033008127087016835 0.07981520677475061 0.0215537361216367 0.004510827414281533 0.028351742991430208 1.097283089744258e-07 6.959681313671274 -0.7159033521454317 down ELFSQFGK(ub)TLSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELFSQFGKTLSVK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 29587200.0 9553800.0 10057000.0 9976400.0 True False 12525124.319130814 8556534.801878965 8944137.82838623 1.0 0.6831496904832917 0.7140957327445443 23.57832158728898 -9.996246979703107 5.883268141160292 1.0000003747678712 0.6986227118921908 0.9921543347395287 0.012633668850000442 6.209837413222175e-08 1.0580553507194996e-08 0.012232512484228101 0.004077499088096877 1.0086790954242385e-10 9.996246979703107 -0.30137766287568035 ELFSQFGK(ub)TLSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELFSQFGKTLSVK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 34672100.0 11905000.0 13050000.0 9717100.0 True False 11527082.291467544 18260933.05485098 7171900.003248585 1.0 1.584176515193953 0.6221782600231192 23.45852405176169 -6.7423349277088365 1.6780702778962484 1.3466494798928887 0.6213182102689169 0.6153384299761666 0.24543884998264628 0.31364511552580343 1.735020815942697 0.11566433549870572 0.28311418856134285 1.809943726463689e-07 6.7423349277088365 -0.7253312696239719 ELFSQFGK(ub)TLSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELFSQFGKTLSVK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 47801000.0 14543000.0 22482000.0 10776000.0 True False 22062794.235714745 18469911.447332256 8646118.87671142 1.0 0.8371519604454084 0.391886847347526 24.395112182916076 -6.953515513062022 0.5188180357225677 1.007635919810841 0.201572379371533 0.9994490606447491 0.006033042214342937 0.08210409002168798 0.030352476191295163 0.006847595576947674 0.036774923817259254 1.1129726365473894e-07 6.953515513062022 -0.8060635404393082 down ELFSQFGK(ub)TLSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELFSQFGKTLSVK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 27580900.0 9553800.0 9690400.0 8336700.0 True False 13086098.041737167 9262246.086132456 6367743.159725989 1.0 0.7077928085660973 0.4866036567521144 23.64153164881187 -7.422365105678 0.15116883001387227 1.287740759198669 3.5510253214633645e-11 0.9999889129651924 0.0007000849367357645 0.12411459172448047 0.0116355657926468 0.032905513004432306 0.059596687965560245 3.7812456669244736e-08 7.422365105678 -1.2877407591631587 down ELFSQFGK(ub)TLSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELFSQFGKTLSVK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 39970000.0 11905000.0 15212000.0 12853000.0 True False 9899534.980923321 15130049.9366544 15540502.874442512 1.0 1.5283596619245678 1.5698215021604038 23.238929327195965 -11.58136331748219 0.4179544020086472 6.07067851552667e-21 1.5716619075521625 0.999719133289214 0.004347244842231664 4.2398181838269995 0.2090956409730847 3.818311040651031 0.010103012039006041 2.6220241204250996e-12 11.58136331748219 1.5716619075521625 ELFSQVCK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELFSQVCKK 9 1 Q9Y5T5-2;Q9Y5T5;Q9Y5T5-3;Q9Y5T5-5 Q9Y5T5-2 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 2601560.0 762730.0 906680.0 932150.0 True False 999946.4162878272 771406.8782109593 835700.0598141825 1.0 0.7714482152700826 0.8357448421252528 19.931491262297133 -9.848725500580306 5.8495513076221135 1.0000000362001111 0.803596528697321 0.9256016245008203 0.026248987997446037 1.2382099984271477e-08 2.460251530280777e-09 0.02541547788632307 0.008471824447229272 1.4166889269896412e-10 9.848725500580306 -0.19640350750279012 ELFSQVCK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELFSQVCKK 9 1 Q9Y5T5-2;Q9Y5T5;Q9Y5T5-3;Q9Y5T5-5 Q9Y5T5-2 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 2054020.0 762730.0 828860.0 462430.0 True False 1044731.8930032225 792238.2245265155 353213.55804480036 1.0 0.7583172580757729 0.3380901458166845 19.994701323820024 -6.9626873189748935 0.3957466536055574 1.0242124905631687 0.05695583161851396 0.999857243490692 0.0032675648802956425 0.07875481362052372 0.017684260556548217 0.005412065250837493 0.03526563481283672 1.0897143777136282e-07 6.9626873189748935 -0.9672566589446547 down ELFVQSEIFPLETPAFAIK(ub)EQGFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELFVQSEIFPLETPAFAIKEQGFR 24 1 P49915 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 151391000.0 45663000.0 50092000.0 55636000.0 True False 69274109.41246249 41152691.22941768 44639520.213874966 1.0 0.5940558684687222 0.644389665814228 26.045812922758607 -10.30503242121601 4.688333867081845 1.0002101023632173 0.6192227671407668 0.9870644689642317 0.02054868672128427 4.5151519586090416e-05 6.692982189366618e-06 0.019907054003689906 0.0066320601211538 4.954132055361152e-11 10.30503242121601 -0.38098733522245043 ELFVQSEIFPLETPAFAIK(ub)EQGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELFVQSEIFPLETPAFAIKEQGFR 24 1 P49915 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 99216000.0 45663000.0 27516000.0 26037000.0 True False 59111653.652297124 25984710.411492042 21298533.162180576 1.0 0.43958693093476425 0.3603102238936078 25.816939244851056 -13.999999999999998 0.2754987898112159 5.456054342008316 0.3353665807268839 0.9995952653621947 0.005727847216347102 15.160022252628906 0.16621138775084 37.96019627635991 0.032045050584639356 1.0000000000000041e-14 13.999999999999998 -5.120687761281432 ELGIQVHSVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELGIQVHSVTR 11 0 Q96GQ7;B7Z6D5;A0A087X059 Q96GQ7 DDX27 Probable ATP-dependent RNA helicase DDX27 0 4828700.0 1562100.0 1352400.0 1914200.0 False True 2047928.227397919 1150627.1916139103 1716136.9463029655 1.0 0.561849373537806 0.8379868607424173 20.965733724217003 -10.477504815481836 6.056976764893241 1.0002053518329759 0.6999181171401119 0.6115886750296232 0.11273265708426959 0.0003128236148003776 2.6985288114411706e-05 0.1092267225290283 0.03638430862175728 3.3303906953218985e-11 10.477504815481836 -0.300287234692864 ELGITALHIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELGITALHIK 10 0 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 188086000.0 55050000.0 48474000.0 84562000.0 False True 72171083.1049583 41241868.15017205 75812335.41598134 1.0 0.5714458807580047 1.0504530645012986 26.104917570332052 -6.670771105537579 1.934158963339726 0.7266507462682461 1.0485460122841301 0.2827312801537887 0.18200555460438653 0.45931348425903684 3.313273534218404 0.07572801299053375 0.20215846272349627 2.1341694285973583e-07 6.670771105537579 0.32189526601588403 ELGITALHIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELGITALHIK 10 0 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 128570000.0 44943000.0 14035000.0 69592000.0 False True 43516309.06555441 19639248.69155811 51363767.48475116 1.0 0.4513077766308925 1.1803337320583664 25.375052860537014 -6.705323133468269 1.8117151218609888 0.6610812503106015 1.1784083397198175 0.4429540683276727 0.23139178162448873 0.38454814091451356 2.4573790571859466 0.10174940704401607 0.25998352373376615 1.97095571598193e-07 6.705323133468269 0.517327089409216 ELGITALHIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELGITALHIK 10 0 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 156186000.0 40386000.0 115800000.0 0.0 False True 61268514.6120866 95134585.2504705 0.0 1.0 1.5527483545635534 0.0 25.868642539392404 -6.8285884762687274 1.4563937820354111 1.2998462128902508 1.5973769273704494e-20 0.8603842728168868 0.2401133933292795 0.1962514980869677 0.8346653966493568 0.1318642430838548 0.2862814974721546 1.4839235382255786e-07 6.8285884762687274 -1.2998462128902508 down ELGITALHIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELGITALHIK 10 0 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 168489000.0 55050000.0 50924000.0 62515000.0 False True 75403472.67031236 48674009.2968514 47750244.53683949 1.0 0.6455141596683409 0.6332632018901642 26.168127631854944 ELGITALHIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELGITALHIK 10 0 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 100154000.0 44943000.0 25470000.0 29741000.0 False True 37372095.812485196 25332788.05460082 35959705.59315301 1.0 0.6778530211874736 0.9622073584949886 25.15545813597129 -10.235994736582137 7.494811205857993 1.000000338161689 0.8200301905047337 0.3481497956548796 0.11608717209177767 6.559906118835083e-07 6.693106737862952e-08 0.1124011329268096 0.0374669736849808 5.807714561194524e-11 10.235994736582137 -0.1799701476569554 ELGITALHIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELGITALHIK 10 0 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 91254000.0 40386000.0 50868000.0 0.0 False True 52280473.127076015 48037151.08343424 0.0 1.0 0.9188354314750039 0.0 25.639768861484853 -7.096336764989949 0.9944005999229361 1.0014277509029468 8.926178396497255e-18 0.9893892504762445 0.04671291224579099 0.08459892771323628 0.15925582274979413 0.03842586759580133 0.06795059953923993 8.0105665908927e-08 7.096336764989949 -1.0014277509029468 down ELGITALHIK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELGITALHIKLR 12 1 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 1 10287600.0 1702700.0 2294100.0 6290800.0 True False 1648648.7205108586 3210146.0935734557 4643050.760045303 1.0 1.9471377095896716 2.81627656776186 20.6528526041431 -6.972153384031045 0.20018072231625605 0.48387246741123874 4.3035433141399535 0.999994666127351 0.0017130051053891834 0.07560997301992795 0.006464988453486424 0.028176178353006193 0.092227565013313 1.0662194875568149e-07 6.972153384031045 3.8196708467287146 ELGITALHIK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELGITALHIKLR 12 1 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 1 6846000.0 1702700.0 2229300.0 2914000.0 True False 1415870.4923996746 2217290.3184185945 3523303.927186304 1.0 1.5660262222575465 2.488436580957956 20.433257879577376 -6.963843610416873 0.3773792693315718 0.9347423782543574 3.1522036453207956 0.999887278093196 0.006512821553059668 0.07835567482997874 0.016257677214121493 0.012038684794111552 0.07804225017352226 1.0868169162829153e-07 6.963843610416873 2.2174612670664384 ELGLDEGVDSLK(ub)AAIQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELGLDEGVDSLKAAIQSR 18 1 Q8WXX5 Q8WXX5 DNAJC9 DnaJ homolog subfamily C member 9 1 12711500.0 3790900.0 5200300.0 3720300.0 True False 3670559.954533747 7276806.909206239 2745841.8233923404 1.0 1.9824786951697062 0.7480716450362765 21.807568736481596 -6.694690457671948 1.8500843962479327 1.613229612623631 0.7521179166484754 0.39235304030802765 0.4151324607992913 0.40664159206206263 2.702143993160007 0.17928106581705788 0.4640614789834805 2.0198054621587625e-07 6.694690457671948 -0.8611116959751556 ELGLDEGVDSLK(ub)AAIQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELGLDEGVDSLKAAIQSR 18 1 Q8WXX5 Q8WXX5 DNAJC9 DnaJ homolog subfamily C member 9 1 14698500.0 3790900.0 7893200.0 3014400.0 True False 3152301.3153449954 7850677.764922476 3644697.102989153 1.0 2.490459185074216 1.1562020055783495 21.587974011915872 -6.619653643722544 2.1185298694447163 1.9892223889801177 1.161334719649959 0.08148258032580502 0.6410106645890001 0.5863144296077079 5.000125680061572 0.24869286606973665 0.7105750667146893 2.400746786845857e-07 6.619653643722544 -0.8278876693301587 ELGLGLGLGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELGLGLGLGLK 11 0 K7ER08;K7EQ03;K7EP90;Q9BTD8-4;Q9BTD8-2;Q9BTD8-3;Q9BTD8 K7ER08 RBM42 RNA-binding protein 42 0 5184590.0 2866100.0 863490.0 1455000.0 False True 2775117.224323822 1208286.0600408628 1073891.8509356363 1.0 0.435400007412397 0.3869717075455427 21.40411728326573 -13.999999999999998 0.3478203301118908 7.850697057503097 0.3800866193964507 0.9997505343711455 0.004395171843371084 20.44504863279539 0.18969958425011543 103.37697332941913 0.01455785012751256 1.0000000000000041e-14 13.999999999999998 -7.470610438106646 ELGLGLGLGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELGLGLGLGLK 11 0 K7ER08;K7EQ03;K7EP90;Q9BTD8-4;Q9BTD8-2;Q9BTD8-3;Q9BTD8 K7ER08 RBM42 RNA-binding protein 42 0 34496700.0 7893700.0 13828000.0 12775000.0 False True 11975320.006770363 11360285.361342879 10250015.650518594 1.0 0.948641485565332 0.8559283296583013 23.51356087265835 -6.961998513494554 0.4062929147931567 1.0047559527844339 0.7963938937456877 0.9998372697965116 0.0007605152531753311 0.07899485501945078 0.018549671061062315 0.0011929571689254456 0.007750399229756854 1.0914440722428973e-07 6.961998513494554 -0.20836205903874616 ELGLGLGLGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELGLGLGLGLK 11 0 K7ER08;K7EQ03;K7EP90;Q9BTD8-4;Q9BTD8-2;Q9BTD8-3;Q9BTD8 K7ER08 RBM42 RNA-binding protein 42 0 28030400.0 7893700.0 11128000.0 9008700.0 False True 10218550.25808943 10508717.017701829 7369209.037067864 1.0 1.028396078923494 0.7211599347210815 23.2846871947508 -6.884294787194895 1.0555805377809484 1.0188358548227878 0.6975127041108725 0.9769868418069069 0.021029543504027786 0.12389271129527195 0.2498862119721911 0.015282616073335172 0.03739461925921222 1.3052845959507682e-07 6.884294787194895 -0.3213231507119153 ELGRVK(ub)DEIQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELGRVKDEIQR 11 2 A0A494C1Q3;Q9UFE4;Q9UFE4-2 A0A494C1Q3 CCDC39 Coiled-coil domain-containing protein 39 1 32763900.0 16017000.0 13845000.0 2901900.0 True False 13318845.173410207 13770414.236982675 3508673.8731303783 1.0 1.0339045208269244 0.263436794064932 23.666965661423934 -6.896607641778905 0.9824773219573091 1.0350824488717172 0.18791439034605142 0.9848012743046458 0.04382470179236107 0.1139451720739228 0.19184220689042267 0.03365724313157381 0.08616997464753545 1.268797628451274e-07 6.896607641778905 -0.8471680585256658 down ELGSECGIEFDEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELGSECGIEFDEEK 14 0 A0A0C4DGS1;P39656;P39656-2;U3KQ84 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 0 7850400.0 1397400.0 3039200.0 3413800.0 False True 1832004.9324408483 2585763.2067088117 3060572.723481906 1.0 1.41143899829118 1.6706138009160223 20.80499195703762 -9.161495291404197 0.09569974910837743 1.5231593939626347e-22 2.50031782231023 0.9999651230434247 0.0016306593049912224 0.6260784397185792 0.033333155696773975 0.5044541650714993 0.34281564581213697 6.894530681409253e-10 9.161495291404197 2.50031782231023 ELGSSVALYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELGSSVALYSR 11 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 45490000.0 11072000.0 14375000.0 20043000.0 False True 14515499.221400512 12230306.033311117 17969142.62603195 1.0 0.8425687499111099 1.2379279797376626 23.791090854629683 -6.798643220003006 1.4613556635106748 0.9129878994410718 1.243210151108792 0.8281917879894101 0.06736250924110991 0.22269969101315717 0.9390501528543012 0.036265210825092896 0.08441355501168496 1.5898523018423364e-07 6.798643220003006 0.33022225166772023 ELGSSVALYSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELGSSVALYSR 11 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 25742300.0 6613100.0 5401200.0 13728000.0 False True 6403170.760327931 7557927.326885904 10132224.968827797 1.0 1.180341366766679 1.5823761926831523 22.61035505372035 -6.957867919923755 0.4645079885399057 0.9887943192758601 1.7902531267737287 0.999682764775852 0.004335725630685686 0.08047172428598054 0.024013405437966453 0.005503138592924129 0.0331970456850484 1.1018743668081485e-07 6.957867919923755 0.8014588074978686 ELGSSVALYSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELGSSVALYSR 11 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 77311000.0 7814000.0 46862000.0 22635000.0 False True 11854409.279919913 38499109.96552285 18161182.32872707 1.0 3.2476616131970553 1.5320191753029946 23.49892043751956 -6.577677836318432 2.2759149009810087 2.5327265426341667 1.536090561576791 0.0 0.9770227807437966 0.7063721881693396 6.87861343400011 0.3609789882277607 1.0928733618757354 2.6443696479014145e-07 6.577677836318432 -0.9966359810573757 ELGSSVALYSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELGSSVALYSR 11 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 48861000.0 11072000.0 13200000.0 24589000.0 False True 15165617.609549472 12616780.353437271 18781584.62635123 1.0 0.8319331713528599 1.2384318997021828 23.854300916152575 -6.794445341496197 1.4787098193108277 0.9066073770475805 1.2432890888124302 0.8153521295821274 0.07166610543578184 0.22878831752715129 0.9881525810175679 0.038140260948991 0.08900818393964381 1.605294281069712e-07 6.794445341496197 0.3366817117648496 ELGSSVALYSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELGSSVALYSR 11 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 17155200.0 6613100.0 7242100.0 3300000.0 False True 5499085.660003697 7203085.369855708 3990014.7425239533 1.0 1.3098696429200316 0.7255778486129767 22.390760329154627 -6.7626244932747515 1.6024613901341085 1.179406642999862 0.7231545465653962 0.7015810992686782 0.13038678228846948 0.27856088832916787 1.410348512482757 0.06417902047285207 0.15384328754756701 1.7273307591865223e-07 6.7626244932747515 -0.45625209643446574 ELGSSVALYSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELGSSVALYSR 11 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 47791000.0 7814000.0 24240000.0 15737000.0 False True 10115377.03696758 22891022.691327494 12873027.47525581 1.0 2.26299253183249 1.2726196392097044 23.270046759612008 -10.243818737286189 4.785099950309756 0.9998151375831278 1.7678060855227675 0.44487336907481223 0.40431804034074953 0.0007975676367035886 0.00012603723152241987 0.39157184651768895 0.13049308640009555 5.704022930207323e-11 10.243818737286189 0.7679909479396397 ELGVGIALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELGVGIALR 9 0 Q01469 Q01469 FABP5 Fatty acid-binding protein, epidermal 0 28867500.0 7910400.0 8209100.0 12748000.0 False True 10370611.00442256 6984334.278821171 11428959.247450734 1.0 0.6734737496028627 1.102052641119876 23.30599756000997 -6.703048593697399 1.81989558837986 0.7978468686724951 1.1008564160057208 0.43205100903794835 0.1377559084215065 0.3892429236409223 2.508385550388406 0.060338103622084936 0.15459827967254333 1.9813053229239666e-07 6.703048593697399 0.3030095473332257 ELGVGIALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELGVGIALR 9 0 Q01469 Q01469 FABP5 Fatty acid-binding protein, epidermal 0 30960500.0 15393000.0 5658000.0 9909500.0 False True 14904357.640702209 7917268.906080218 7313904.671372294 1.0 0.5312049735346529 0.4907225690424123 23.829230862516564 -13.999999999999998 0.3468369580667092 6.653928349140261 0.4848931604907959 0.9997486364184761 0.00366436361866554 20.349328291091375 0.18936414536134555 84.6380683135659 0.012210675167241426 1.0000000000000041e-14 13.999999999999998 -6.169035188649465 ELGVGIALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELGVGIALR 9 0 Q01469 Q01469 FABP5 Fatty acid-binding protein, epidermal 0 31504700.0 7910400.0 8205300.0 15389000.0 False True 10835088.65052205 7842762.714701425 11754435.146403637 1.0 0.7238300458504832 1.0848490054428204 23.369207621532862 -6.702320031436066 1.8228622334308413 0.8288943728594249 1.0838122018419252 0.4284168463132566 0.11652691609852357 0.39074628932661293 2.5258821816397483 0.05097029160686988 0.13069509782535318 1.9846319038926876e-07 6.702320031436066 0.25491782898250026 ELGVGIALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELGVGIALR 9 0 Q01469 Q01469 FABP5 Fatty acid-binding protein, epidermal 0 23683100.0 15393000.0 3860300.0 4429800.0 False True 12799961.525523107 3839503.797690446 5356050.698918971 1.0 0.29996213582630543 0.4184427186159125 23.60963613795084 -9.980977148567536 5.900288075065382 1.0000006225761444 0.3592024272310327 0.9750012053223287 0.04836949537755543 3.961350985150026e-07 6.830569537709417e-08 0.0468336075246673 0.015611187505065696 1.04477519109499e-10 9.980977148567536 -0.6407981953451117 ELGYLNK(ub)MDLPYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELGYLNKMDLPYR 13 1 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 1 13490500.0 1834200.0 2204900.0 9451400.0 True False 1775974.3249903177 3085328.0684015984 6975794.8040777175 1.0 1.737259387698873 3.9278691735116995 20.760179294324754 -6.951666606229121 0.5402366340292203 0.9677986862802807 4.798533467748247 0.9993256698629195 0.03228885014477582 0.08282333190022385 0.03324545656516302 0.035502536038517385 0.18142038825513548 1.1177209566033809e-07 6.951666606229121 3.8307347814679664 ELGYLNK(ub)MDLPYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELGYLNKMDLPYR 13 1 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 1 12186500.0 1834200.0 2696400.0 7655900.0 True False 1525218.568837423 2681873.9580065045 9256713.29311792 1.0 1.7583538600967374 6.069106082398225 20.54058456975903 -6.936989121029069 0.6870011764415194 0.948178597616086 7.135369181778746 0.9977423726650626 0.10607258339114144 0.0891674164797509 0.06106800467142726 0.10103459000817476 0.37620256267842983 1.1561412028847404e-07 6.936989121029069 6.18719058416266 ELHINLIPNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELHINLIPNK 10 0 P07900;P07900-2;G3V2J8;Q14568 P07900 HSP90AA1;HSP90AA2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 0 185427000.0 0.0 73597000.0 111830000.0 False True 0.0 62616614.47885903 100258904.34910695 0.0 ELHINLIPNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELHINLIPNK 10 0 P07900;P07900-2;G3V2J8;Q14568 P07900 HSP90AA1;HSP90AA2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 0 225966000.0 82450000.0 37136000.0 106380000.0 False True 79832669.8808482 51964598.4616817 78515886.66840765 1.0 0.6509189601104394 0.9835057099505018 26.250475924816183 -10.62136600245373 9.198272863668128 1.0000601406419574 0.8172123353631049 0.2871085028043546 0.13577797205313796 0.00016751283441494865 6.895332548835555e-06 0.13150949784727523 0.0438221520453016 2.3912996349224945e-11 10.62136600245373 -0.18284780527885247 ELHINLIPNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELHINLIPNK 10 0 P07900;P07900-2;G3V2J8;Q14568 P07900 HSP90AA1;HSP90AA2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 0 209787000.0 57031000.0 106970000.0 45786000.0 False True 86520196.52458549 87880367.73957524 36736377.031283304 1.0 1.015720852120386 0.42459886254239304 26.366533606496205 -6.900790205358703 0.9562520795859004 1.024046640853494 0.3615437352221414 0.9869555578088711 0.031411460730789695 0.11082617313054366 0.1741546364616244 0.024599327459024187 0.06426123298515031 1.2566368606816353e-07 6.900790205358703 -0.6625029056313527 down ELHINLIPNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELHINLIPNK 10 0 P07900;P07900-2;G3V2J8;Q14568 P07900 HSP90AA1;HSP90AA2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 0 195147000.0 0.0 77587000.0 117560000.0 False True 0.0 74158949.79410125 89794749.22419992 0.0 ELHINLIPNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELHINLIPNK 10 0 P07900;P07900-2;G3V2J8;Q14568 P07900 HSP90AA1;HSP90AA2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 0 192542000.0 82450000.0 62162000.0 47930000.0 False True 68560828.15431556 61827120.96780905 57951941.39671907 1.0 0.9017849205183112 0.8452631474386776 26.03088120025046 -13.999999999975294 0.062217019454756405 1.610530313046378 0.6026344740692767 0.9999483179424666 0.000459564263864418 12.441201999194304 0.06462604129079763 1.1633338703058562 0.2264963005923764 1.0000000000568867e-14 13.999999999975294 -1.007895838977101 ELHINLIPNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELHINLIPNK 10 0 P07900;P07900-2;G3V2J8;Q14568 P07900 HSP90AA1;HSP90AA2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 0 152782000.0 57031000.0 62395000.0 33356000.0 False True 73827753.74907815 58922663.40038691 27285550.261462323 1.0 0.7981099303203796 0.36958391493528303 26.137659928588654 -6.958865184707015 0.4511459138710112 1.0136583624176974 0.1370149656348378 0.9997257570576513 0.004352892509906243 0.08010906403305453 0.02264847062526614 0.005737544548750144 0.03544020984690165 1.0993470498310173e-07 6.958865184707015 -0.8766433967828595 down ELHINLIPNK(ub)QDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELHINLIPNKQDR 13 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 14492400.0 3474200.0 4594600.0 6423600.0 True False 4554709.844200657 3909103.589610525 5758947.49152216 1.0 0.858255239812442 1.2643939325476057 22.118927720021954 -6.812430308405735 1.4043341412940853 0.9229688735157396 1.271897974938722 0.8660622730522487 0.06159605747358084 0.20350973473651965 0.790563880682941 0.0344841318428441 0.07968314903731234 1.5401736591695009e-07 6.812430308405735 0.3489291014229824 ELHINLIPNK(ub)QDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELHINLIPNKQDR 13 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 21488600.0 4900600.0 8113300.0 8474700.0 True False 4745033.135452817 11352983.00030056 6254921.83444965 1.0 2.392603523772263 1.3182040369150645 22.17798673121472 -10.136883191353961 5.832742262201213 0.9999920962489115 1.8554037803436976 0.4580476082606828 0.43862175378482304 4.5081342723308464e-05 6.6711441959273205e-06 0.424697605697329 0.14156456230772488 7.296537328809261e-11 10.136883191353961 0.8554116840947861 ELHINLIPNK(ub)QDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELHINLIPNKQDR 13 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 104687000.0 20846000.0 29500000.0 54341000.0 True False 31624906.046737935 24235494.515448004 43600477.53149361 1.0 0.7663420242144201 1.3786753221355716 24.914557857975588 -6.803306250850159 1.44257002845895 0.8716163802516759 1.387815085322424 0.8415987288780049 0.10041852294751821 0.21607522794188122 0.8873813482284553 0.054756284864619274 0.12708407242307465 1.5728733323562933e-07 6.803306250850159 0.5161987050707482 ELHINLIPNK(ub)QDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELHINLIPNKQDR 13 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 24471600.0 3474200.0 7104500.0 13892900.0 True False 4758705.626724782 6790599.698560233 10611683.15325695 1.0 1.4269846111985536 2.2299515846624303 22.182137781544846 -6.961231130312018 0.417720922527205 0.9636244975985575 2.723488720659827 0.9998131691085818 0.006969429032790516 0.07926423166148984 0.019527764702964114 0.010372963128380075 0.0668838444680285 1.0933743206402866e-07 6.961231130312018 1.7598642230612696 up ELHINLIPNK(ub)QDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELHINLIPNKQDR 13 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 18817100.0 4900600.0 9479700.0 4436800.0 True False 4075066.0333904056 9428630.974526877 5364514.366554618 1.0 2.313736979295614 1.3164239113179246 21.958392006648996 -10.172204963607825 4.6248697925415945 0.999880200177561 1.8150804453146587 0.47106392893218196 0.4071513550896678 0.0005080149364199951 9.092787678418712e-05 0.39428044681036356 0.1314075347996934 6.726591224790225e-11 10.172204963607825 0.8152002451370978 ELHINLIPNK(ub)QDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELHINLIPNKQDR 13 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 127787400.0 20846000.0 34038400.0 72903000.0 True False 26985557.93609239 32144133.117841695 59635402.04794914 1.0 1.1911605901929438 2.209900650902924 24.685684180068037 -6.938394055525182 0.6743465887540576 0.9881850815659361 2.4721049183229287 0.9979457917056496 0.024069481672633928 0.08850711395398322 0.058005477338146524 0.023153911819478804 0.08831940767340724 1.1524071508477605e-07 6.938394055525182 1.4839198367569926 up ELHINLIPNKQDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELHINLIPNKQDR 13 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 423936300.0 116805800.0 118752000.0 188378500.0 False True 153133534.94897643 101034664.49167052 168886899.87416834 1.0 0.659781441898634 1.1028733838766334 27.190215014547412 -6.7015958725713665 1.8254232276004931 0.7890671870764325 1.1015852002768998 0.4250685738454827 0.14356901693662993 0.39219852872941463 2.541899121571391 0.06272247603580097 0.16097399539489426 1.9879439138852966e-07 6.7015958725713665 0.31251801320046724 ELHINLIPNKQDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELHINLIPNKQDR 13 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 332536100.0 130478500.0 66413200.0 135644400.0 False True 126336531.43781982 92932337.10026275 100115062.39522606 1.0 0.735593545608794 0.7924474517056105 26.912696627864484 -10.77845836315802 7.022385565366283 1.0065633185105756 0.7640204986572812 0.9582817055542147 0.02321050997021834 0.002424139673445414 7.647647595650837e-05 0.022841954440707326 0.007491159880969734 1.6654884944630314e-11 10.77845836315802 -0.2425428198532944 ELHINLIPNKQDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELHINLIPNKQDR 13 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 772040000.0 189920000.0 582120000.0 0.0 False True 288122525.01182336 478236137.87568104 0.0 1.0 1.6598359946208865 0.0 28.102107211865153 -6.812690210454395 1.495146003833602 1.3637508293663527 1.6722993035127007e-18 0.8282153616536396 0.28281384920199965 0.21424874493607318 0.9579419100501584 0.1507747540699957 0.33429277211063313 1.5392522232487118e-07 6.812690210454395 -1.3637508293663527 ELHINLIPNKQDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELHINLIPNKQDR 13 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 557006800.0 116805800.0 172281000.0 267920000.0 False True 159992060.81805608 164669055.76291844 204642813.98560393 1.0 1.029232668927123 1.279081055267642 27.253425076070304 -6.928885387883302 0.7558735401061363 0.9960395066161707 1.3289494715914303 0.9963148975810427 0.0076026836337645684 0.09322026583668824 0.08054230080766607 0.006881096035263094 0.02274700959100625 1.1779167896369443e-07 6.928885387883302 0.3329099649752596 ELHINLIPNKQDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELHINLIPNKQDR 13 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 246273100.0 130478500.0 79253600.0 36541000.0 False True 108498653.92762713 78826645.126192 44181554.15350536 1.0 0.726521871679371 0.40720831599418916 26.69310190329876 -6.969085798858479 0.27915828913377844 1.0710629919599088 0.052948195677386574 0.9999743476097581 0.0012269246782451663 0.07660045276633622 0.010087461178436884 0.005926849106259203 0.029340237475472833 1.0737772568389606e-07 6.969085798858479 -1.0181147962825223 down ELHINLIPNKQDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELHINLIPNKQDR 13 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 483659000.0 189920000.0 94669000.0 199070000.0 False True 245855183.88288727 89400586.92926086 162841302.63069057 1.0 0.3636310836213512 0.6623464271075112 27.873233533957603 -10.496751512186835 6.285644853926074 1.0003344242186964 0.512988755364513 0.7799327149149753 0.12195002831355051 0.0005718987241543634 4.5787924196297556e-05 0.11815590755106554 0.03935920239399198 3.186019927289709e-11 10.496751512186835 -0.4873456688541834 ELHLSFTQGFWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELHLSFTQGFWR 12 0 Q969N2;A0A1W2PNP0;A0A1W2PP57;A0A1W2PPC3;A0A1W2PPS0;Q969N2-5;A0A1W2PPQ7;A0A1W2PPR6;A0A1W2PRZ8;A0A1W2PRH2;A0A1W2PP13;Q969N2-6;A0A1W2PR92;A0A1W2PRH8;A0A1W2PNW9;A0A1W2PPU8;A0A1W2PPI8;A0A1W2PQ29;A0A1W2PRG1;A0A1W2PRV7;A0A1W2PP91;A0A1W2PP98;B7Z7C5;A0A1W2PQL3;A0A1W2PNS2;A0A1W2PNZ5;A0A1W2PP03;A0A1W2PR22 Q969N2 PIGT GPI transamidase component PIG-T 0 8250400.0 2229200.0 2181500.0 3839700.0 False True 3381859.376349811 1792194.2808627055 3080781.611999703 1.0 0.529943466424408 0.910972713278494 21.689385240526626 -9.95028945783146 6.831789303311482 1.0000000188384723 0.72045808985145 0.41781105265675755 0.15555453864491928 4.4547144812104724e-08 6.8987962840764596e-09 0.15061504337702783 0.05020501146656176 1.1212708767156567e-10 9.95028945783146 -0.27954192898702235 ELHLSFTQGFWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELHLSFTQGFWR 12 0 Q969N2;A0A1W2PNP0;A0A1W2PP57;A0A1W2PPC3;A0A1W2PPS0;Q969N2-5;A0A1W2PPQ7;A0A1W2PPR6;A0A1W2PRZ8;A0A1W2PRH2;A0A1W2PP13;Q969N2-6;A0A1W2PR92;A0A1W2PRH8;A0A1W2PNW9;A0A1W2PPU8;A0A1W2PPI8;A0A1W2PQ29;A0A1W2PRG1;A0A1W2PRV7;A0A1W2PP91;A0A1W2PP98;B7Z7C5;A0A1W2PQL3;A0A1W2PNS2;A0A1W2PNZ5;A0A1W2PP03;A0A1W2PR22 Q969N2 PIGT GPI transamidase component PIG-T 0 7416200.0 2229200.0 1978100.0 3208900.0 False True 2885743.344101368 1868016.9961103513 2624913.126094449 1.0 0.6473261040101469 0.9096142009510056 21.460511562619075 -9.931423239354725 5.5052570095851 1.0000002901633398 0.7784701524799781 0.4874800479607295 0.10707866718723116 3.814334926732418e-07 7.408600473035348e-08 0.10367860963914462 0.0345594912288807 1.1710535653085585e-10 9.931423239354725 -0.22153013768336172 ELHNTPYGTASEPSEK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELHNTPYGTASEPSEKAK 18 1 Q9NXV2 Q9NXV2 KCTD5 BTB/POZ domain-containing protein KCTD5 1 19874000.0 4136200.0 12993000.0 2744800.0 True False 4004898.595041411 18181172.65759991 2025854.5377650424 1.0 4.539733585292418 0.5058441530263252 21.93333428304855 -6.674903284179511 1.9199172953394887 3.249746782751055 0.5216892880293409 0.3010549590873225 1.5019126674793517 0.4499045605046929 3.2016813234145465 0.6287365530440407 1.6692049938470341 2.1139597586627786e-07 6.674903284179511 -2.728057494721714 ELHNTPYGTASEPSEK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELHNTPYGTASEPSEKAK 18 1 Q9NXV2 Q9NXV2 KCTD5 BTB/POZ domain-containing protein KCTD5 1 34424800.0 6705600.0 3583500.0 24135700.0 True False 10172885.445025714 2943996.426986705 19365268.315946877 1.0 0.2893964001556948 1.9036160802750421 23.27822560857914 -6.787045273058687 1.5081640428256535 0.6013174382023161 1.9194052595253526 0.7916078307932585 0.3015505361192751 0.23977717316690877 1.077470150324931 0.15741051227708558 0.36933808802972773 1.6328817191525445e-07 6.787045273058687 1.3180878213230365 ELHNTPYGTASEPSEK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELHNTPYGTASEPSEKAK 18 1 Q9NXV2 Q9NXV2 KCTD5 BTB/POZ domain-containing protein KCTD5 1 22014800.0 4136200.0 15611000.0 2267600.0 True False 3439433.5647286847 15526900.444459103 2741744.6758022113 1.0 4.514377193874923 0.7971500609631604 21.713739558482825 -6.658820208696976 1.9767085222914953 3.2643186959168595 0.8125654992843692 0.2307234781219295 1.4967580816292765 0.48726686738290653 3.658668240979529 0.6119640808540969 1.6594040085728416 2.1937129111375688e-07 6.658820208696976 -2.4517531966324904 ELHNTPYGTASEPSEK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELHNTPYGTASEPSEKAK 18 1 Q9NXV2 Q9NXV2 KCTD5 BTB/POZ domain-containing protein KCTD5 1 57663100.0 6705600.0 14921500.0 36036000.0 True False 8680531.387137162 14091105.407947319 29477817.76058453 1.0 1.6232998625899289 3.3958540607623227 23.04935193067159 -6.9526459466720425 0.528997504753762 0.9718414383257097 4.127641749073983 0.9993929097131844 0.025006824303019898 0.0824403242963014 0.03169730896118564 0.027940273124470023 0.14656203735068854 1.1152033191319622e-07 6.9526459466720425 3.1558003107482735 ELHQQYK(ub)EASEVKPPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELHQQYKEASEVKPPR 16 2 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 1 3773550.0 1345200.0 1715500.0 712850.0 True False 1763570.2269353324 1459554.0869666245 639091.1201400419 1.0 0.8276132499146257 0.36238484318859876 20.75006759563218 -6.953803142822964 0.5154126184969566 1.0081951539993983 0.1612037015043576 0.9994668860475264 0.0062179606221970714 0.08199374758531472 0.029914348733527846 0.007096732550384618 0.03841198542544808 1.1122357677122571e-07 6.953803142822964 -0.8469914524950407 down ELHQQYK(ub)EASEVKPPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELHQQYKEASEVKPPR 16 2 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 1 8070400.0 3175100.0 2041100.0 2854200.0 True False 4816858.830902699 1676849.7578129114 2290066.118959701 1.0 0.34812100928825906 0.4754272855720236 22.1996612123811 -10.00865590950842 6.161196267713523 1.000000458858294 0.41177414743271584 0.9660626463987515 0.05197256965826818 3.2755558487402675e-07 5.26991323489615e-08 0.05032226317699932 0.01677407472882496 9.802663405207141e-11 10.00865590950842 -0.5882263114255781 ELIEK(ub)GHGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELIEKGHGIR 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 5680500.0 1479900.0 2263800.0 1936800.0 True False 1940163.2313719857 1926049.8642232863 1736398.5150974747 1.0 0.9927256805404362 0.894975477846563 20.887746604821245 -6.921826152360995 0.8110656823500924 1.0020181500295924 0.8785305772155941 0.9946733335439163 0.003494954130231482 0.09710931157198587 0.1001330791306357 0.003040747873019429 0.009273788670569738 1.1972196812188863e-07 6.921826152360995 -0.12348757281399825 ELIEK(ub)GHGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELIEKGHGIR 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 7155800.0 1975100.0 2148000.0 3032700.0 True False 1912401.5316150812 3005707.6016720245 2238344.890950175 1.0 1.571692739198767 1.170436675534256 20.86695403555674 -10.627295219217814 5.514729487611088 0.9967334929153961 1.3710647073665112 0.532761847833648 0.16381210202929608 0.00662542621368217 0.00044776901269716145 0.15973125037455865 0.05287012858889111 2.3588742023454988e-11 10.627295219217814 0.37433121445111506 ELIEK(ub)GHGIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELIEKGHGIR 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 43530800.0 5743900.0 7769900.0 30017000.0 True False 8713916.235338097 6383300.63849422 24084126.793081544 1.0 0.7325409685036466 2.7638694408619235 23.05488981438318 -6.87374764745712 1.1140213356180482 0.8446843135409157 2.8916553425446274 0.9682852829052926 0.160487082069355 0.13331526844441674 0.30695019613360974 0.11152452682441738 0.2659096460922768 1.337372388703011e-07 6.87374764745712 2.0469710290037115 up ELIEK(ub)GHGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELIEKGHGIR 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 5638800.0 1479900.0 2165600.0 1993300.0 True False 2027059.0227937386 2069916.6313184623 1522523.5933021214 1.0 1.0211427531427557 0.7510997835690768 20.950956666344137 -6.8879804879636 1.034297863608758 1.0152200648661611 0.7287757610530009 0.9795723084508526 0.01752555711007642 0.12079523998332854 0.23156296402298518 0.012944144779226277 0.032042777610548016 1.2942539885476336e-07 6.8879804879636 -0.2864443038131602 ELIEK(ub)GHGIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELIEKGHGIR 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 7636900.0 1975100.0 3458400.0 2203400.0 True False 1642383.161765783 3439768.9127613464 2664120.7526294785 1.0 2.094376630763269 1.6221067133720428 20.647359310991018 -10.291149093639406 5.203022774664374 0.9998240285603619 1.8582416720677766 0.8149275988320773 0.1928033864128984 0.0003936418223033509 5.362888890637185e-05 0.18671850512239724 0.06222702538906852 5.115062049099334e-11 10.291149093639406 0.8584176435074147 ELIEK(ub)GHGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELIEKGHGIR 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 29924400.0 5743900.0 5356500.0 18824000.0 True False 7435591.779196058 5058406.066258077 15398225.15055063 1.0 0.6802963659746522 2.070880920821005 22.82601613647563 -6.846221575387485 1.2532560250124904 0.8298047356404287 2.1225291777054984 0.9346201467962052 0.15205477136811962 0.1616572740748641 0.4905203610997811 0.09502726545049849 0.21942368550954827 1.4248804395591514e-07 6.846221575387485 1.2927244420650696 up ELIIGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELIIGDR 7 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 12627670.0 960970.0 6867300.0 4799400.0 False True 1259840.9760467177 5842725.60852574 4302804.127095631 1.0 4.637669134131321 3.4153549605899416 20.264810209757552 -10.537687144702367 8.52528572435105 0.99965360742259 4.026512047360584 0.8910014868780768 0.49900767175801786 0.0032857978640266896 0.00017818496739809383 0.4831949911588244 0.161054033529045 2.8994315162815926e-11 10.537687144702367 3.0268584399379943 ELIIGDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELIIGDR 7 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 11503900.0 5194300.0 1308000.0 5001600.0 False True 5029409.789716072 1830291.2211298882 3691530.9152162774 1.0 0.3639176956453999 0.7339888912541122 22.261957676430544 -10.728739506073241 7.016834880165237 1.0056341891200447 0.5489532934498949 0.6645044869905754 0.15108093295717465 0.013371800012412437 0.000516933152044624 0.14689295079056053 0.0487611614393847 1.8674994987801018e-11 10.728739506073241 -0.4566808956701498 ELIIGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELIIGDR 7 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 17256670.0 960970.0 9163100.0 7132600.0 False True 1316266.578237786 8758243.943680383 5448026.780508064 1.0 6.653852713791378 4.138999554179874 20.328020271280444 -9.411393380654165 9.450880339516154 1.0000000227691375 5.396426133985648 0.802950353741647 1.0266845031791234 0.0 0.0 0.9940830252814399 0.3313609985518193 3.8779894151021795e-10 9.411393380654165 4.396426111216511 ELISNASDALDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELISNASDALDK 12 0 P08238;P14625;Q96GW1;A0A1W2PRR1;F8W026 P08238;P14625 HSP90AB1;HSP90B1 Heat shock protein HSP 90-beta;Endoplasmin 0 211939800.0 5545800.0 114590000.0 91804000.0 False True 7270597.505603596 97493618.66832168 82305002.72615057 1.0 13.409299386079534 11.320252931442905 22.79364250058726 -9.482772232997698 12.25164076579595 0.9999872043273139 12.36477615775482 0.9752846327912804 0.852849643836994 0.0 0.0 0.8257681168354434 0.2752560389451477 3.290241433022063e-10 9.482772232997698 11.364788953427507 ELISNASDALDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELISNASDALDK 12 0 P08238;P14625;Q96GW1;A0A1W2PRR1;F8W026 P08238;P14625 HSP90AB1;HSP90B1 Heat shock protein HSP 90-beta;Endoplasmin 0 234591000.0 63941000.0 30560000.0 140090000.0 False True 61911227.9545338 42762767.368294634 103396226.39008494 1.0 0.6907110193275223 1.6700722923153257 25.883697738358507 -6.8218147478452105 1.3642002020335464 0.8335984566538491 1.6922616916764264 0.8884643267919662 0.1365153262668611 0.19113545455335454 0.6984835918078858 0.07863116260252713 0.18113279071539537 1.5072498598493083e-07 6.8218147478452105 0.8586632350225772 ELISNASDALDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELISNASDALDK 12 0 P08238;P14625;Q96GW1;A0A1W2PRR1;F8W026 P08238;P14625 HSP90AB1;HSP90B1 Heat shock protein HSP 90-beta;Endoplasmin 0 253585800.0 5545800.0 142640000.0 105400000.0 False True 7596232.129609783 136337693.1525978 80506690.7811388 1.0 17.948068308913232 10.59823994415958 22.856852562110152 -9.5180551481286 7.73099397994315 1.0000346285077344 14.273154126539142 0.8130292907271832 3.000554865190044 0.0 0.0 2.905274582369262 0.9684249185103746 3.033505955264127e-10 9.5180551481286 13.273119498031408 ELISNASDALDK(ub)IR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELISNASDALDKIR 14 1 P08238;P14625;Q96GW1;A0A1W2PRR1;F8W026 P08238;P14625 HSP90AB1;HSP90B1 Heat shock protein HSP 90-beta;Endoplasmin 1 55963000.0 15518500.0 21118500.0 19326000.0 True False 20344903.78136776 17967702.119268246 17326330.908082295 1.0 0.883154932181267 0.8516300246133417 24.278164121596774 -13.999990937318652 0.1838618560776987 1.6136530449035644 0.8275618409230957 0.9994939782581662 0.0014356794087245367 12.257079971331608 0.1359577502833801 2.689648320491731 0.022787207691302745 1.0000208678127054e-14 13.999990937318652 -0.7860912039804687 ELISNASDALDK(ub)IR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELISNASDALDKIR 14 1 P08238;P14625;Q96GW1;A0A1W2PRR1;F8W026 P08238;P14625 HSP90AB1;HSP90B1 Heat shock protein HSP 90-beta;Endoplasmin 1 79030400.0 25299600.0 21835400.0 31895400.0 True False 24496478.04630087 30554389.090106707 23541037.89851032 1.0 1.2472972250278493 0.96099683611723 24.54607100648495 -6.678217217095168 1.9083635211746042 1.1567178600981944 0.9621044871079237 0.3159491664294284 0.104851527510681 0.44247875389847974 3.1140384343440712 0.04411361323147123 0.11660703202909256 2.0978903385696964e-07 6.678217217095168 -0.1946133729902707 ELISNASDALDK(ub)IR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELISNASDALDKIR 14 1 P08238;P14625;Q96GW1;A0A1W2PRR1;F8W026 P08238;P14625 HSP90AB1;HSP90B1 Heat shock protein HSP 90-beta;Endoplasmin 1 255978100.0 49054900.0 71727200.0 135196000.0 True False 74419869.69356836 58926920.75282848 108474451.34148814 1.0 0.7918170375125121 1.4576006621369144 26.149184528571926 -6.822673104330189 1.3602186888807264 0.8880835210427832 1.4729920251550483 0.8904332366311998 0.09205020515537893 0.19002908796691304 0.690107568011912 0.053168482729974646 0.12246926154802433 1.5042738146289605e-07 6.822673104330189 0.5849085041122651 ELISNASDALDK(ub)IR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELISNASDALDKIR 14 1 P08238;P14625;Q96GW1;A0A1W2PRR1;F8W026 P08238;P14625 HSP90AB1;HSP90B1 Heat shock protein HSP 90-beta;Endoplasmin 1 63894000.0 15518500.0 18403000.0 29972500.0 True False 21256108.821693774 17589894.60941713 22893612.80301403 1.0 0.8275218553390664 1.0770368647929123 24.341374183119665 -6.720729152500154 1.7565509404346344 0.8951493450936793 1.0766677168600984 0.516020299892076 0.07257296559844321 0.3539026764131736 2.1344020599363422 0.03279918389276643 0.08227205244260972 1.9022642560598442e-07 6.720729152500154 0.18151837176641916 ELISNASDALDK(ub)IR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELISNASDALDKIR 14 1 P08238;P14625;Q96GW1;A0A1W2PRR1;F8W026 P08238;P14625 HSP90AB1;HSP90B1 Heat shock protein HSP 90-beta;Endoplasmin 1 70381600.0 25299600.0 34358000.0 10724000.0 True False 21037738.362315606 34172906.634470925 12966338.81782631 1.0 1.6243621840874316 0.6163371078448527 24.326476281919227 -6.739243947486942 1.6902575391696357 1.371834942485869 0.6159339477375447 0.6012163917860469 0.2623328537951919 0.3191789066010222 1.7903454473372107 0.12281623560058184 0.30153816248768145 1.8228714898259652e-07 6.739243947486942 -0.7559009947483242 ELISNASDALDK(ub)IR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELISNASDALDKIR 14 1 P08238;P14625;Q96GW1;A0A1W2PRR1;F8W026 P08238;P14625 HSP90AB1;HSP90B1 Heat shock protein HSP 90-beta;Endoplasmin 1 143584900.0 49054900.0 75965000.0 18565000.0 True False 63502535.06664203 71737480.97139819 15186360.49298623 1.0 1.1296790103909093 0.23914573610406376 25.920310850664375 -6.869921632725633 1.134569976192328 1.0733007717239023 0.18708274746123243 0.9646018486398802 0.07390664265330571 0.13692689083622445 0.3294880753889044 0.05055847162277318 0.11967779631346834 1.349206321288811e-07 6.869921632725633 -0.8862180242626698 down ELISNASDALEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELISNASDALEK 12 0 Q12931-2;Q12931 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 13497070.0 2636500.0 979470.0 9881100.0 False True 2552805.7506471355 1370577.4788685725 7292943.483354042 1.0 0.5368906265277456 2.8568344777135053 21.283652332983824 -6.85479680072238 1.2115639532393865 0.751418136208069 2.9586032019695567 0.9470107203329489 0.2307616794912415 0.15226652773791002 0.4276818375357036 0.14882442135762802 0.34565036165067065 1.397021851817003e-07 6.85479680072238 2.2071850657614878 up ELISNSSDALDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELISNSSDALDK 12 0 P07900;P07900-2;G3V2J8;Q14568 P07900 HSP90AA1;HSP90AA2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 0 62295900.0 23135000.0 5130900.0 34030000.0 False True 22400592.088458747 7179695.127290018 25116522.121882956 1.0 0.3205136319137362 1.1212436717163166 24.41703353005665 -6.6818678437849135 1.8952980365586376 0.5708005048443379 1.118237398131108 0.332657420700208 0.2878661492860866 0.43439586547109277 3.018515342599745 0.12180320208829237 0.32047554427154457 2.0803296370401159e-07 6.6818678437849135 0.5474368932867701 ELISNSSDALDK(ub)IR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELISNSSDALDKIR 14 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 18618700.0 5228200.0 6655600.0 6734900.0 True False 6854220.829960829 5662610.423325607 6038037.153722623 1.0 0.8261493995894451 0.8809224714980667 22.70856124282076 -10.01694373754256 6.3625758878989735 1.0000000814631145 0.8535359355437535 0.9050676230182704 0.02236101297015779 2.5846843419848705e-08 4.005823580917937e-09 0.021650969646511073 0.007216985903144475 9.617368624545391e-11 10.01694373754256 -0.14646414591936097 ELISNSSDALDK(ub)IR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELISNSSDALDKIR 14 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 19359900.0 5571100.0 6400200.0 7388600.0 True False 5394248.47996596 8955833.236602085 5453304.00675124 1.0 1.6602559689016403 1.010947869198946 22.362990548546563 -6.642256662036794 2.0359234764971754 1.4310164759604243 1.0136362047670748 0.1634729975374668 0.2823423360009644 0.527690780861374 4.182942826518017 0.11281530468883498 0.3127267303421788 2.2789948194935325e-07 6.642256662036794 -0.4173802711933494 ELISNSSDALDK(ub)IR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELISNSSDALDKIR 14 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 90717000.0 18163000.0 25633000.0 46921000.0 True False 27554598.893164203 21058590.87845688 37647043.78379513 1.0 0.7642495889744609 1.3662707967465526 24.715789790508985 -6.80049397721925 1.453862710960183 0.870003067309846 1.3746848197376225 0.8335895413056936 0.10104209573626423 0.22006748911319404 0.9182846841575518 0.05467250711440889 0.12711185557646346 1.583091520812287e-07 6.80049397721925 0.5046817524277765 ELISNSSDALDK(ub)IR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELISNSSDALDKIR 14 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 19444000.0 5228200.0 5851100.0 8364700.0 True False 7161206.826792512 5592579.054999758 6389130.13640408 1.0 0.7809548293000024 0.8921862321445835 22.771771304343652 -10.15073921518591 4.8077385841601 1.0000134991509713 0.8365705307214076 0.7421588500119174 0.04541003006024609 6.571079482811987e-06 1.1607109492337912e-06 0.04397170343411801 0.014656024180742565 7.06741810646659e-11 10.15073921518591 -0.16344296842956363 ELISNSSDALDK(ub)IR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELISNSSDALDKIR 14 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 15305300.0 5571100.0 9734200.0 0.0 True False 4632616.491576803 9681759.932512583 0.0 1.0 2.0899118133599712 0.0 22.14339582398084 -6.769805290464279 1.6067015198790418 1.6289281180997555 3.324375507436587e-11 0.7107851924796278 0.45898292322384016 0.27113666013779986 1.3864446568335893 0.22635475196808863 0.53212742372693 1.699005205698527e-07 6.769805290464279 -1.6289281180665116 ELISNSSDALDK(ub)IR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELISNSSDALDKIR 14 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 95180000.0 18163000.0 15366000.0 61651000.0 True False 23512361.54625568 14510868.592200419 50431150.59267946 1.0 0.6171591298327607 2.1448781524334195 24.486916112601435 -6.840345211919623 1.2809262450273387 0.796355916701662 2.195427100484052 0.9250242944396323 0.17771724836328992 0.16839716351879275 0.536590420312274 0.10878921362850094 0.2506338121536112 1.4442912763590433e-07 6.840345211919623 1.3990711837823904 up ELK(ub)AFNIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELKAFNIR 8 1 Q16531;F5GY55;F5H2L3;F5GWI0 Q16531 DDB1 DNA damage-binding protein 1 1 7814500.0 4271800.0 1096500.0 2446200.0 True False 3552190.9728272334 1090592.9368617919 2957689.1100491164 1.0 0.30701979291214043 0.8326379782714932 21.760277715242072 -10.046752492015813 6.934458576974902 1.0000001055324177 0.5698288855922049 0.47175462329271967 0.21458272560967478 3.500687510915063e-07 4.7771836371091315e-08 0.207768880202872 0.06925627688917199 8.97940392293012e-11 10.046752492015813 -0.4301712199402128 ELK(ub)ATYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELKATYR 7 1 O95229;O95229-2 O95229 ZWINT ZW10 interactor 1 27478900.0 8464200.0 11118000.0 7896700.0 True False 8195508.604068838 15557475.379604047 5828317.374077979 1.0 1.898292849315075 0.711159935965949 22.966402053462726 -6.704338005707912 1.8154609025907558 1.5554164176866359 0.7143952902104184 0.4381713555351181 0.37888805298608436 0.3865593506371311 2.479858547782563 0.1663135015120466 0.42542926642351203 1.9754315891306991e-07 6.704338005707912 -0.8410211274762175 ELK(ub)ATYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELKATYR 7 1 O95229;O95229-2 O95229 ZWINT ZW10 interactor 1 18990200.0 5888600.0 6203900.0 6897700.0 True False 8065774.553431457 5929791.184446167 5268605.3225907115 1.0 0.7351793860793482 0.6532051308512294 22.943381650843822 -13.999999999999787 0.16421144523078376 2.3164811841560384 0.5762510867097165 0.9995259290296018 0.0032222640659183275 12.040390939042776 0.1281881901142427 5.047762240771743 0.07052619570920282 1.0000000000004908e-14 13.999999999999787 -1.740230097446322 ELK(ub)ATYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELKATYR 7 1 O95229;O95229-2 O95229 ZWINT ZW10 interactor 1 23532300.0 8464200.0 10166000.0 4902100.0 True False 7038357.327638061 10111233.740206987 5927106.445250497 1.0 1.4365899981381203 0.8421150233416071 22.746807328897003 -6.709881785026156 1.7956201966672642 1.2684371361388704 0.843515806864428 0.464552385464713 0.18397977660448278 0.37530865382273493 2.358790426572239 0.08153926625841514 0.20717824380412153 1.950375419770685e-07 6.709881785026156 -0.4249213292744425 ELK(ub)EPPQGAHFLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELKEPPQGAHFLSR 14 1 P00374;P00374-2;B4DM58 P00374 DHFR Dihydrofolate reductase 1 9217900.0 2281500.0 2544400.0 4392000.0 True False 2991068.5940774297 2164785.4379935213 3937557.97103888 1.0 0.7237498472218192 1.3164385393352662 21.512229565438613 -6.779999259742112 1.5362242413596534 0.8435778195272412 1.3211038222585156 0.7672623575767498 0.11681991195510974 0.2505809614217644 1.1681215609079842 0.059897825502998964 0.14131308839642914 1.6595897362171024e-07 6.779999259742112 0.47752600273127443 ELK(ub)EPPQGAHFLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELKEPPQGAHFLSR 14 1 P00374;P00374-2;B4DM58 P00374 DHFR Dihydrofolate reductase 1 29657100.0 6148400.0 3916300.0 19592400.0 True False 5953222.407464006 5480099.013234703 14460562.680598883 1.0 0.9205265044967726 2.4290311516782204 22.505239362590192 -6.894466688351853 0.995566603928945 0.9274104189310497 2.5707342110566174 0.9836072038039363 0.08874619277711498 0.11559447570729396 0.20126803831278295 0.06748979584534222 0.17119995292540227 1.2750678976040954e-07 6.894466688351853 1.6433237921255677 up ELK(ub)EPPQGAHFLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELKEPPQGAHFLSR 14 1 P00374;P00374-2;B4DM58 P00374 DHFR Dihydrofolate reductase 1 226538500.0 7362000.0 7171500.0 212005000.0 True False 11168692.2342936 5891689.793814756 170102118.8249076 1.0 0.527518322666664 15.230262886339284 23.412956931719943 -6.899474203568119 0.9645782364900314 0.37986356925255865 16.757230723818136 0.9863031286879661 0.7984388637916036 0.11179360412334217 0.17960734586677143 0.6214295988097328 1.6126441495262391 1.2604505045143755e-07 6.899474203568119 16.377367154565576 up ELK(ub)EPPQGAHFLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELKEPPQGAHFLSR 14 1 P00374;P00374-2;B4DM58 P00374 DHFR Dihydrofolate reductase 1 15450100.0 2281500.0 4754000.0 8414600.0 True False 3125032.2052192157 4543952.560624293 6427244.784126843 1.0 1.4540498344417998 2.056697135278317 21.575439626961504 -6.967210410916646 0.31783696692792834 0.9153444566193784 2.614778933909425 0.9999517280346537 0.00300710281718856 0.0772186599819188 0.012255825002103983 0.009216384117050454 0.05311278264390815 1.0784241109780207e-07 6.967210410916646 1.6994344772900467 ELK(ub)EPPQGAHFLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELKEPPQGAHFLSR 14 1 P00374;P00374-2;B4DM58 P00374 DHFR Dihydrofolate reductase 1 26617700.0 6148400.0 9606100.0 10863200.0 True False 5112667.020303141 9554350.032638436 13134644.89423822 1.0 1.8687604717257604 2.5690397677139236 22.28564463802447 -6.97357254643944 0.15002491010856567 0.1862334738917433 4.269985195518954 0.9999985436490036 0.0007744836747917806 0.07515958364181421 0.004585770866780832 0.035730129790090534 0.08735005025376093 1.0627410435607536e-07 6.97357254643944 4.083751721627211 ELK(ub)EPPQGAHFLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELKEPPQGAHFLSR 14 1 P00374;P00374-2;B4DM58 P00374 DHFR Dihydrofolate reductase 1 174457300.0 7362000.0 23761300.0 143334000.0 True False 9530254.126715532 22438962.76713863 117248682.73103611 1.0 2.3544978411684707 12.30278659646238 23.184083253812393 -6.931722445496543 0.7325160810210507 0.8579685757829784 14.437683774086702 0.996866070748212 0.28211082183520547 0.09175325968046244 0.07337076993855955 0.25970171009467613 0.8917755541045191 1.1702470486188333e-07 6.931722445496543 13.579715198303724 ELK(ub)IDIIPNPQER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELKIDIIPNPQER 13 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 49755000.0 12563000.0 18481000.0 18711000.0 True False 16470214.660265055 15723706.838373786 16774965.208585719 1.0 0.9546752827883753 1.018503131538163 23.97335602238945 -6.715995764252609 1.77392943243158 0.9723077804013762 1.018380754131152 0.49350873868888 0.019082708473200125 0.36313282876647335 2.231030606928125 0.008549256322082005 0.021561894275191444 1.923110485239875e-07 6.715995764252609 0.04607297372977581 ELK(ub)IDIIPNPQER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELKIDIIPNPQER 13 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 93692000.0 31816000.0 29954000.0 31922000.0 True False 30806018.49519789 41914788.40804639 23560670.56052745 1.0 1.3606038837696652 0.7648073886666056 24.876708898409202 -6.742847092578531 1.676158536832088 1.2138494664806245 0.7642299809172275 0.6176664633516125 0.1515050633290086 0.31270778745458827 1.726076491282246 0.07147329452027112 0.1748516456971263 1.8078105121463652e-07 6.742847092578531 -0.44961948556339704 ELK(ub)IDIIPNPQER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELKIDIIPNPQER 13 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 490006000.0 77826000.0 226760000.0 185420000.0 True False 118067731.84272407 186292906.31603348 148771655.72752708 1.0 1.5778477608445207 1.2600534744387497 26.81503948614191 -10.136195824590818 4.530374762762278 0.9999643504557011 1.4189506174705797 0.698545162927382 0.12973897448865138 90633183.9785817 5.170998776618554 48353.51532033524 0.04441310176726459 7.308094851494207e-11 10.136195824590818 0.4189862670148786 ELK(ub)IDIIPNPQER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELKIDIIPNPQER 13 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 56730000.0 12563000.0 18408000.0 25759000.0 True False 17207880.602309436 17594673.69288432 19675254.7232576 1.0 1.0224776716850867 1.1433862878277423 24.03656608391234 -6.938188400801328 0.6762001458494448 0.9985909392134464 1.1743249847942911 0.9979169562938708 0.002873838824440859 0.08860271487456194 0.05844512905563085 0.0027604796186805037 0.010492120574216945 1.1529529880776254e-07 6.938188400801328 0.1757340455808447 ELK(ub)IDIIPNPQER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELKIDIIPNPQER 13 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 85254000.0 31816000.0 32317000.0 21121000.0 True False 26456413.687782943 32142901.906577736 25537303.44752977 1.0 1.214937983881795 0.9652594546222416 24.65711417384348 -6.678929608203035 1.9060110708164666 1.1361256203835315 0.9662244216467811 0.3191340375205668 0.09111736612048443 0.4408792185224219 3.095810010414883 0.03837547935347367 0.10133984771117276 2.0944519036030596e-07 6.678929608203035 -0.16990119873675036 ELK(ub)IDIIPNPQER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELKIDIIPNPQER 13 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 397176000.0 77826000.0 121880000.0 197470000.0 True False 100747291.17981032 115097270.8588695 161532486.2133041 1.0 1.1424353896865358 1.6033432196703576 26.58616580823436 -6.949737422293905 0.5617170767667445 0.9940252475938969 1.7738459796549937 0.9991805289075851 0.007371239466192212 0.08359131587956348 0.03639977375949877 0.007885261818132436 0.03832840353030909 1.1226970402062177e-07 6.949737422293905 0.7798207320610968 ELK(ub)QLQEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELKQLQEER 9 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 25439000.0 16880800.0 2056000.0 6502200.0 True False 25609407.751788057 1689090.7363986787 5217037.319984497 1.0 0.06595586874830192 0.20371565678320855 24.610170553482796 -10.666159734094192 6.516637513690507 1.005775406517047 0.13483576276624415 0.9813392855650399 0.056240197959914764 0.00471506263951159 0.00024154727359790998 0.05440829853483696 0.018151445840513182 2.15695093378829e-11 10.666159734094192 -0.8709396437508028 ELK(ub)QLQEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELKQLQEER 9 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 10005830.0 7994200.0 1293300.0 718330.0 True False 10949871.775131915 1236157.7296288186 548675.2484707342 1.0 0.11289243883533297 0.050107915392837946 23.384410639931644 -13.561402252489763 0.3802648893967629 9.998761950517032 0.04452274491984011 0.9997971971945464 0.006176881087843006 17.090916673048298 0.20047360572043754 124.2070897849237 0.017009815243267043 2.745350175292315e-14 13.561402252489763 -9.954239205597192 ELK(ub)QLQEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELKQLQEER 9 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 30169700.0 16880800.0 11172800.0 2116100.0 True False 21852528.370315097 10551023.85831946 1730991.5130195592 1.0 0.4828285166604418 0.07921241348762974 24.381296875575245 -8.08630495359149 0.4377310806470934 1.0508181297222168 2.5968389588532716e-17 0.9961763885662194 0.02330337187447615 0.09908796038128764 0.10804095717098869 0.05029740482862947 0.08011806803264267 8.197757107684513e-09 8.08630495359149 -1.0508181297222168 ELK(ub)QLYLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELKQLYLER 9 1 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 1 6167800.0 2705100.0 0.0 3462700.0 True False 3546412.2962256665 0.0 3104413.0205638306 1.0 0.0 0.8753672052930107 21.757928839103602 -9.080314715539487 11.699509563265247 1.0000065650474728 0.437683602718691 0.35492147197160184 0.35736716510915434 0.0 0.0 0.34601926972817154 0.11533975657605716 8.311612440821984e-10 9.080314715539487 -0.5623229623287818 ELK(ub)QLYLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELKQLYLER 9 1 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 1 88388700.0 3371800.0 16061900.0 68955000.0 True False 5115267.111598917 13195528.45280252 55326014.025949836 1.0 2.579636246733144 10.815860211971643 22.286378146639347 -6.938874939218968 0.6699499787855013 0.9055073180574488 12.965266020922778 0.9980127684209368 0.19184346400764946 0.08828374410537106 0.05697561543485655 0.18518983054361238 0.7124615806734146 1.1511318246988928e-07 6.938874939218968 12.059758702865329 ELK(ub)QLYLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELKQLYLER 9 1 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 1 8525700.0 2705100.0 2700600.0 3120000.0 True False 3705248.5725787873 2581278.5623100502 2383120.2584170112 1.0 0.6966546270102267 0.6431741924289851 21.821138900626494 -13.999999999999998 0.24413193635657515 3.048813604606656 0.6204374647833778 0.9995320132419315 0.0033991480792297003 13.772926741233558 0.15636453372834855 13.790123579060973 0.025512836925035105 1.0000000000000041e-14 13.999999999999998 -2.428376139823278 ELK(ub)QLYLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELKQLYLER 9 1 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 1 67779500.0 3371800.0 14439700.0 49968000.0 True False 4364861.568114572 13636118.001483573 40874336.71497632 1.0 3.124066545682862 9.364406196421994 22.057504468731796 -6.951919823723355 0.5373542589902004 0.9064929482402725 11.868855610693236 0.9993434580257886 0.09095962598841328 0.0827238774952118 0.03284192158898205 0.10041278038101245 0.5165759082452747 1.1170694539531652e-07 6.951919823723355 10.962362662452964 ELK(ub)TDFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELKTDFIK 8 1 O15247 O15247 CLIC2 Chloride intracellular channel protein 2 1 6992400.0 1293700.0 3284600.0 2414100.0 True False 1696053.2282086217 2794550.483270524 2164312.0896823653 1.0 1.6476785261168598 1.2760873619328095 20.693750016859482 -10.0436546626391 4.2630547372747225 0.9999633138750975 1.4618829437355862 0.6732049475483813 0.15170145789984832 15163414.717733834 5954108.042149385 5251.255179756882 0.051931444090161184 9.04368313224211e-11 10.0436546626391 0.46191962986048873 ELK(ub)TDFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELKTDFIK 8 1 O15247 O15247 CLIC2 Chloride intracellular channel protein 2 1 8237200.0 1507800.0 1661700.0 5067700.0 True False 1459935.7143279905 2325225.4756510206 3740317.3422587803 1.0 1.592690316998871 2.561974000328125 20.47747341331844 -6.963781697093793 0.37838590870438754 0.932199371976466 3.256653286801704 0.999885777090238 0.006880847802832892 0.07837692892093572 0.016333309431923005 0.01263604236678914 0.08196749996574533 1.0869718647021156e-07 6.963781697093793 2.3244539148252383 ELK(ub)TDFIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELKTDFIK 8 1 O15247 O15247 CLIC2 Chloride intracellular channel protein 2 1 31044300.0 3032800.0 7308500.0 20703000.0 True False 4600979.327379201 6004241.073428865 16611042.975552745 1.0 1.3049919693616592 3.6103276701777074 22.133509543619166 -6.93116820432612 0.7371424686678271 0.9664169369872043 4.097990810686394 0.9967628023235978 0.066301582180971 0.09203608565954632 0.07474258451246009 0.06082878523616971 0.20726999059777326 1.1717414565933355e-07 6.93116820432612 3.1315738736991894 up ELK(ub)TDFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELKTDFIK 8 1 O15247 O15247 CLIC2 Chloride intracellular channel protein 2 1 5684700.0 1507800.0 1871700.0 2305200.0 True False 1253802.5068656995 1861616.7805966393 2787206.6619594577 1.0 1.4847767255230455 2.2230029424067883 20.257878688752715 -6.965005485969284 0.35796472138572744 0.934889556143975 2.7981082036995617 0.9999132506368364 0.004683507563518296 0.07795916755842401 0.014853829667675983 0.009946410983112212 0.06313142511276804 1.0839132220392712e-07 6.965005485969284 1.8632186475555867 ELK(ub)TDFIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELKTDFIK 8 1 O15247 O15247 CLIC2 Chloride intracellular channel protein 2 1 35010900.0 3032800.0 4350100.0 27628000.0 True False 3926019.38542555 4108013.1109547783 22599987.487219147 1.0 1.0463557888187813 5.7564635495984655 21.904635865711615 -6.909054056498122 0.9021620756315006 0.8497672270535277 6.352989223474873 0.990559450467077 0.2168057098445875 0.1050466092857259 0.14218854601851058 0.1766757208187489 0.4845611213428687 1.232951358608248e-07 6.909054056498122 5.503221996421345 up ELK(ub)TDNLPNQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELKTDNLPNQAR 12 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;X6R242 O95758-1 PTBP3 Polypyrimidine tract-binding protein 3 1 33935100.0 3966800.0 5081300.0 24887000.0 True False 6017925.611925556 4174502.3146218928 19968073.54164042 1.0 0.6936779521417475 3.318099097481405 22.520834842833345 -6.877817971874373 1.0919511473279149 0.8151298434327089 3.496440039954266 0.9718798698281441 0.19647569584571462 0.12957788786251911 0.28414604812353317 0.13887106477820155 0.33402650516601184 1.3248967297558925e-07 6.877817971874373 2.681310196521557 up ELK(ub)TDSSPNQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELKTDSSPNQAR 12 1 P26599;P26599-2;P26599-3;A6NLN1;A0A087WU68;K7ES59 P26599 PTBP1 Polypyrimidine tract-binding protein 1 1 4946450.0 2017400.0 858550.0 2070500.0 True False 3060543.2916957247 705335.0446182333 1661264.7674676129 1.0 0.23046073111661014 0.5428006105893612 21.545356344680872 -10.505142414707834 6.222083404715988 1.0005113012878628 0.38663067086030223 0.8371852968068956 0.12751222183843972 0.0009051172474318481 7.198570647661385e-05 0.12355942944486979 0.04115439263484855 3.1250544250377e-11 10.505142414707834 -0.6138806304275606 ELLALCLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLALCLK 8 0 C9JA08;Q96D46;C9IY70;C9IZW9;C9K0C2;C9J0B9 C9JA08 NMD3 60S ribosomal export protein NMD3 0 5755500.0 1103000.0 1933800.0 2718700.0 False True 1446043.6814671957 1645284.5778933612 2437395.0036118845 1.0 1.1377834563227096 1.6855611174475977 20.463679702584344 -6.945015774245534 0.611129253534801 0.9939504927602655 1.8579755513191318 0.9987497177429879 0.0104696427714368 0.08555122474739434 0.044737898040816265 0.010630815354749345 0.04620833081747847 1.1349695910772745e-07 6.945015774245534 0.8640250585588664 ELLALCLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLALCLK 8 0 C9JA08;Q96D46;C9IY70;C9IZW9;C9K0C2;C9J0B9 C9JA08 NMD3 60S ribosomal export protein NMD3 0 8144100.0 1103000.0 2930200.0 4110900.0 False True 1510808.9074542176 2800734.075124382 3139990.086643101 1.0 1.8537976982434845 2.078350260678651 20.526889764107235 -10.747229188438585 0.26863012895757116 9.507895795651106e-11 2.172304202290003 0.999166713206188 0.013409935575419652 2.4978651899673583 0.13650159731860093 1.7048034233734588 0.09305028627924235 1.7896611542745337e-11 10.747229188438585 2.172304202194924 ELLDLK(ub)EHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLDLKEHR 9 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 12237000.0 1322600.0 1611100.0 9303300.0 True False 1733941.4080766186 1370730.160018612 8340683.759555108 1.0 0.7905285343748149 4.810245444687226 20.725623718342128 -6.894612521235693 0.9947244991076428 0.807286367220445 5.188874644737219 0.9836891883114437 0.23595378295344516 0.11547941582628748 0.20063772161738622 0.17955715493465257 0.45573599664208864 1.2746398110866431e-07 6.894612521235693 4.381588277516775 up ELLDLK(ub)EHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELLDLKEHR 9 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 137930800.0 8921800.0 54851000.0 74158000.0 True False 13535022.870948203 45062410.49718095 59500638.79539401 1.0 3.3293191246764464 4.396050111086784 23.690193989575693 -9.018256670566224 0.2939859277346784 4.659467031480577e-20 4.901532112425291 0.9987016644931018 0.05109437490679309 0.47862904012667523 0.10223940342386367 0.8961074824810649 0.3723630137824097 9.58833787679884e-10 9.018256670566224 4.901532112425291 ELLDLK(ub)EHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELLDLKEHR 9 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 128236800.0 8921800.0 52294000.0 67021000.0 True False 11549445.974970205 49383792.92987958 54823865.69353247 1.0 4.2758581698986635 4.74688273466502 23.461320311668143 -9.837511638840942 0.4900988917319783 2.2986625439812655e-20 4.741726536232863 0.9989734104279869 0.053392439968906615 1.1258316266859019 0.21963548419694992 1.8926187735685869 0.09702996680452398 1.4537454255489755e-10 9.837511638840942 4.741726536232863 ELLEIVK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLEIVKK 8 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 8740400.0 3069200.0 2440000.0 3231200.0 True False 2971769.925995144 3414304.7244319045 2384851.7860778254 1.0 1.1489128732900042 0.8025021604857987 21.502890996279294 -6.7898624847723745 1.4966946206249376 1.0832403473576482 0.7988215291485299 0.8009569657376916 0.06330067614024976 0.23554348155028645 1.0423445854141775 0.03328915642209403 0.07795218102091866 1.6223237094513616e-07 6.7898624847723745 -0.2844188182091183 ELLEIVK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELLEIVKK 8 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 8726800.0 3069200.0 3445500.0 2212100.0 True False 2552175.788614016 3426938.4076217944 2674639.882405224 1.0 1.3427517112693976 1.0479841922870496 21.28329627171357 -10.111582959725661 4.4870494117418405 0.9999798403983612 1.1953679517860945 0.36936953730827304 0.12033833573555071 2.4271301466595436e-05 4.805683859295563e-06 0.11652911206032919 0.03883903084742335 7.734229240027241e-11 10.111582959725661 0.19538811138773327 ELLEQK(ub)DDMQHQVLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELLEQKDDMQHQVLER 16 1 Q92608;E5RFJ0;F6S220;Q92608-2;H0YB76 Q92608 DOCK2 Dedicator of cytokinesis protein 2 1 41601300.0 2894500.0 12185000.0 26521800.0 True False 4391168.116294876 10010491.548160465 21279754.605082132 1.0 2.279687610003643 4.846035050700198 22.066173338564763 -6.959991564273715 0.43555243301006485 0.903865112639579 6.321180502173135 0.9997698870807108 0.024258367193507064 0.07970413639392825 0.02114242878715046 0.03365838358424395 0.2128260139058281 1.0964994943179436e-07 6.959991564273715 5.417315389533556 ELLEQK(ub)DDMQHQVLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELLEQKDDMQHQVLER 16 1 Q92608;E5RFJ0;F6S220;Q92608-2;H0YB76 Q92608 DOCK2 Dedicator of cytokinesis protein 2 1 27968200.0 2894500.0 0.0 25073700.0 True False 3746987.3091249852 0.0 20510543.8778879 1.0 0.0 5.473875993104877 21.837299660657212 -6.859579984583075 1.1878747506654297 0.4580494259942701 5.7368070353492335 0.9531273335266838 0.5152686746453728 0.14723354636366742 0.395012608977222 0.33838352810151734 0.7895086991584161 1.3817199093026348e-07 6.859579984583075 5.2787576093549635 up ELLGQGLLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLGQGLLLR 10 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 8921600.0 1879100.0 2775400.0 4267100.0 False True 2463518.2972302847 2361321.1384244673 3825581.4249134813 1.0 0.9585157703432863 1.552893448859119 21.232288756308293 -6.890157743841293 1.0214251575628932 0.9681841057854649 1.6041782978323842 0.980999886304913 0.037347194641430506 0.11901624429145731 0.22108919160435056 0.027853384339026337 0.06948008911317347 1.2877817204396623e-07 6.890157743841293 0.6359941920469193 ELLGQGLLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLGQGLLLR 10 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 6955100.0 2284600.0 1509600.0 3160900.0 False True 2212076.623526813 2112391.152460001 2332965.4650326143 1.0 0.9549357965241371 1.0546494819483525 21.076969928887557 -6.7838036113934574 1.5207202092209247 0.9746100968776358 1.055540525161218 0.7807421803426602 0.019090816424232927 0.24469828775261207 1.1178724878474786 0.009884684884952383 0.02325391998645536 1.645115478689307e-07 6.7838036113934574 0.08093042828358221 ELLGQGLLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLGQGLLLR 10 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 9535400.0 1879100.0 3991500.0 3664800.0 False True 2573854.0507681016 3815142.331874611 2799249.718925207 1.0 1.4822683247078747 1.0875712700531104 21.295498817831184 -9.9094972514859 5.235725295684033 0.9999994439039808 1.2849197973838402 0.40995787695337926 0.16113439782562566 1.0458855479896682e-06 2.180220207659229e-07 0.15601801668776355 0.052005903271632396 1.2316937807168377e-10 9.9094972514859 0.28492035347985945 ELLIFNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLIFNK 7 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 9874000.0 1264000.0 3428000.0 5182000.0 False True 1657116.2405934113 2916555.7622393435 4645816.349253977 1.0 1.7600188150922524 2.8035548958172756 20.66024337517006 -6.966685232248873 0.3278442873238879 0.8696257027666278 3.7279998891216293 0.9999437872542296 0.005543094222833623 0.07739364731308905 0.012868106274686684 0.015345997438801893 0.0911794176869 1.0797290041864116e-07 6.966685232248873 2.8583741863550016 ELLIFNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLIFNK 7 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 11459400.0 1264000.0 5424700.0 4770700.0 False True 1731334.958315619 5185018.816915993 3643958.9156506476 1.0 2.994809751869386 2.1047105288024577 20.723453436692953 -10.692452311262688 7.225417708130185 0.9907081119199566 2.5497601403359216 0.8016640127564699 0.3633814861602861 0.05343839927619629 0.0022745859218988983 0.3456768114459199 0.11728087035157407 2.0302414431049315e-11 10.692452311262688 1.559052028415965 ELLIFNK(ub)QQVPSGESAILDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLIFNKQQVPSGESAILDR 20 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 100182000.0 34156000.0 41772000.0 24254000.0 True False 33071736.476049136 58451777.438102216 17901149.79559655 1.0 1.7674238992692006 0.5412824273246352 24.979095462374794 -6.737475766193865 1.6958460539268043 1.4579411913899565 0.5409378551443839 0.5936022071916447 0.32246384819269774 0.32239919401456757 1.8195182882138934 0.15048522763166827 0.37031851152851003 1.8303082353946455e-07 6.737475766193865 -0.9170033362455726 ELLIFNK(ub)QQVPSGESAILDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELLIFNKQQVPSGESAILDR 20 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 180423000.0 41051000.0 46642000.0 92730000.0 True False 62277368.23009873 38318370.6843907 74401874.8549972 1.0 0.6152856450647409 1.1946855971835797 25.892204643284728 -6.727685787352938 1.7315712105973624 0.7678869070301205 1.1942037916818125 0.5485412399996408 0.16175642558537645 0.34059677930347365 1.999568145504426 0.07405972105546185 0.18426441902950083 1.8720360711594858e-07 6.727685787352938 0.42631688465169193 ELLIFNK(ub)QQVPSGESAILDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELLIFNKQQVPSGESAILDR 20 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 88967000.0 34156000.0 37124000.0 17687000.0 True False 28402227.367359642 36924005.643462956 21385269.92455184 1.0 1.3000390837620255 0.7529434099639729 24.75950073780907 -6.757767096266381 1.620597927601516 1.174756022039816 0.7511416884749763 0.6819336603440338 0.12616076033952076 0.2866646317075517 1.4832790390578525 0.0614350877800195 0.14798187091215415 1.7467586546773255e-07 6.757767096266381 -0.4236143335648398 ELLIFNK(ub)QQVPSGESAILDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELLIFNKQQVPSGESAILDR 20 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 169022000.0 41051000.0 43694000.0 84277000.0 True False 53141328.736185744 41262390.48988712 68939450.75504445 1.0 0.7764651632015017 1.297285039621172 25.663330965377178 -6.790101909243493 1.496210123980041 0.875082466066367 1.302817647179741 0.801564630130252 0.0950315972527652 0.23520249105136445 1.0402309295443555 0.049996268699600395 0.11703048637246476 1.6214295766363573e-07 6.790101909243493 0.42773518111337405 ELLIIGGVAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLIIGGVAAR 11 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 6684700.0 2092200.0 2604400.0 1988100.0 False True 2742894.4608936207 2215833.671871685 1782390.4832018195 1.0 0.8078450350400204 0.6498210225052282 21.387267681603458 -6.973363458259014 0.15843093679133444 1.163418408459724 0.29006073165896745 0.999998145070435 0.0001949280241715832 0.07522567075855167 0.004882841103342277 0.007425083108246793 0.019073920225854187 1.0632528163298065e-07 6.973363458259014 -0.8733576768007567 ELLIIGGVAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLIIGGVAAR 11 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 7941000.0 2608900.0 1340800.0 3991300.0 False True 2526081.897539663 1876188.4321796314 2945858.7935666037 1.0 0.7427266843592796 1.1661770730536456 21.268469982503085 -6.742222349277912 1.6783742824984549 0.8473224710366036 1.1665575959482246 0.6149824922477085 0.10809147688615313 0.3137968874410855 1.7364286737966057 0.05092963293692465 0.12468213426466207 1.8104129634563725e-07 6.742222349277912 0.319235124911621 ELLIIGGVAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELLIIGGVAAR 11 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 24331900.0 4021100.0 14353000.0 5957800.0 False True 6100302.6817872925 11791595.009499142 4780238.218603501 1.0 1.932952449179848 0.7836067270686586 22.54044939670132 -6.690832301380399 1.8638919707227761 1.5844542937324781 0.7875840984502493 0.3741795793120537 0.39450742524441706 0.4148536651687286 2.7950676514805926 0.16930005374791807 0.4403367223510532 2.0378288137149545e-07 6.690832301380399 -0.7968701952822288 ELLIIGGVAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLIIGGVAAR 11 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 6757000.0 2092200.0 2097200.0 2567600.0 False True 2865742.8795790663 2004538.7694870182 1961185.761381897 1.0 0.6994831196375351 0.6843551022518688 21.45047774312635 ELLIIGGVAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELLIIGGVAAR 11 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 5452700.0 2608900.0 1205700.0 1638100.0 False True 2169415.943866515 1199204.6547872869 1980619.1362813564 1.0 0.5527776534406601 0.9129734396398558 21.04887525793736 -9.92158669995105 6.6778894263194495 1.0000000167953427 0.7328755465402537 0.42306981201475924 0.1470493139481248 3.678037261282729e-08 5.877617466867229e-09 0.1423798955453774 0.0474599619993571 1.1978799617323782e-10 9.92158669995105 -0.267124470255089 ELLIIGGVAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELLIIGGVAAR 11 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 23010600.0 4021100.0 12466000.0 6523500.0 False True 5205393.2177310325 11772256.14150529 5336289.936762492 1.0 2.2615498290130467 1.0251463652324264 22.31157571879377 -6.641509279709498 2.038767212650558 1.824053296696643 1.0302882081837865 0.16037533316880925 0.5395810174727445 0.5296785991528933 4.209581741542864 0.2153735872199746 0.5975851086050441 2.282920144271039e-07 6.641509279709498 -0.7937650885128564 ELLIQIFSTPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLIQIFSTPR 11 0 Q8TDN6 Q8TDN6 BRIX1 Ribosome biogenesis protein BRX1 homolog 0 2530830.0 971510.0 891460.0 667860.0 False True 1273659.018116223 758457.6428838628 598756.2537654882 1.0 0.5954950517334245 0.4701071835153064 20.28054766268243 -13.999999999999998 0.16401051673515657 3.009941871849675 0.35214097078234463 0.9995263987003795 0.0049206952635426566 12.038846843888294 0.12810462471229617 7.696274501729607 0.10808317459360528 1.0000000000000041e-14 13.999999999999998 -2.6578009010673305 ELLIQIFSTPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLIQIFSTPR 11 0 Q8TDN6 Q8TDN6 BRIX1 Ribosome biogenesis protein BRX1 homolog 0 8760500.0 4068700.0 2805200.0 1886600.0 False True 3939541.3455937826 3925330.9889247427 1392442.8632131775 1.0 0.9963928905873944 0.3534530395957307 21.9095962454641 -6.908130059947953 0.9083627279062538 1.02110339399733 0.27360024418482326 0.9901967477167372 0.030093370442719657 0.10566822003161983 0.14556666385505734 0.02441222149247787 0.06654784687973579 1.2355773546197814e-07 6.908130059947953 -0.7475031498125067 down ELLIQIFSTPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELLIQIFSTPR 11 0 Q8TDN6 Q8TDN6 BRIX1 Ribosome biogenesis protein BRX1 homolog 0 88979000.0 20557000.0 37346000.0 31076000.0 False True 31186471.91800783 30681314.514370203 24933814.978905313 1.0 0.9838020342613383 0.7995073968116259 24.894417016080627 -6.924176188316519 0.7931330462128291 1.0034875328463926 0.7667322304898251 0.9952646479408597 0.006257656242150433 0.09577644954974394 0.09333313023786896 0.0055145085879021605 0.01724016043754459 1.1907588327513636e-07 6.924176188316519 -0.2367553023565675 ELLIQIFSTPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELLIQIFSTPR 11 0 Q8TDN6 Q8TDN6 BRIX1 Ribosome biogenesis protein BRX1 homolog 0 7577400.0 4068700.0 1511800.0 1996900.0 False True 3383304.323971668 1503655.6333311964 2414442.5573776006 1.0 0.4444340471170066 0.7136344609234802 21.690001520898377 -10.456894306009861 6.193436530148781 1.0001822032476881 0.5790342540202496 0.7652843591629017 0.10990060872865741 0.0002766144085160837 2.4256199130003664e-05 0.10645614073573377 0.035470268945345614 3.492252958902109e-11 10.456894306009861 -0.4211479492274386 ELLIQIFSTPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELLIQIFSTPR 11 0 Q8TDN6 Q8TDN6 BRIX1 Ribosome biogenesis protein BRX1 homolog 0 64186000.0 20557000.0 20508000.0 23121000.0 False True 26611441.739050698 19366711.772019163 18913215.24149391 1.0 0.727758832532537 0.7107174209858724 24.665543338173077 -13.999999999999998 0.3940762975257799 5.418033557005126 0.7095753849782239 0.9998292199023316 0.001731997505858303 25.915149920185932 0.2062141537532529 97.68006925825232 0.004433215385951978 1.0000000000000041e-14 13.999999999999998 -4.708458172026902 ELLK(ub)HPVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLKHPVFR 9 1 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 5560740.0 988540.0 1532400.0 3039800.0 True False 1295985.513034977 1303771.8932484158 2725270.6558205774 1.0 1.006008076583514 2.1028558023295014 20.30561816070303 -6.908100139260336 0.9085546196796657 0.9639648022307461 2.2390016912572688 0.9901850727322957 0.051366065197882824 0.10568857899825938 0.14567354367894916 0.041662896468273695 0.11355237272929918 1.2356624825666558e-07 6.908100139260336 1.2750368890265227 up ELLK(ub)HPVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLKHPVFR 9 1 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 5892940.0 988540.0 1314700.0 3589700.0 True False 1354029.9522890206 1256612.2068684828 2741886.792192161 1.0 0.9280534782440737 2.0249823776475067 20.368828222225922 -6.891227660807151 1.0150709859613325 0.9427837770421934 2.1216369128047723 0.9816732248829584 0.06782372413575426 0.11815354508121205 0.21606445316744605 0.050826270984604245 0.1272863642582389 1.284613078468688e-07 6.891227660807151 1.1788531357625789 up ELLK(ub)HPVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELLKHPVFR 9 1 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 11455700.0 2589900.0 4275400.0 4590400.0 True False 2153616.602023794 4252367.571599544 5550231.416388466 1.0 1.974523955472629 2.5771678260526083 21.038330006025586 -8.655680566335963 0.16809461923051028 4.734778708547598e-11 3.485992216455938 0.9998160860463822 0.008812455335624142 0.23785224424651544 0.04674971663115712 0.4843431751920218 0.36816428186959554 2.2096293691158356e-09 8.655680566335963 3.48599221640859 ELLK(ub)PNASVALHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLKPNASVALHK 13 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 34020600.0 8836600.0 10290000.0 14894000.0 True False 11584868.17375614 8754772.110105844 13352911.7533363 1.0 0.755707529753211 1.1526166334447732 23.46573829182814 -6.7402120612542 1.686182048113187 0.854679296175049 1.1528475704918932 0.6057676603627441 0.10264059631120118 0.3174401930649508 1.7722914887648793 0.04815647997916106 0.11813219777785285 1.818812535443807e-07 6.7402120612542 0.29816827431684423 ELLK(ub)PNASVALHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLKPNASVALHK 13 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 43584000.0 13780000.0 10151000.0 19653000.0 True False 13342561.442790655 14204347.236765696 14505289.722637853 1.0 1.0645892318105596 1.0871443076977885 23.669532319195646 -13.999999984509387 0.14668985777398852 0.6891659115375571 1.1129292235950266 0.999577637215458 0.0007589501022402147 11.946736299456171 0.1204403392256581 1.0596319970836199 0.023170362031383836 1.0000000356684558e-14 13.999999984509387 0.4237633120574694 ELLK(ub)PNASVALHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELLKPNASVALHK 13 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 122976000.0 50144000.0 38236000.0 34596000.0 True False 76072114.01744348 31412487.06076847 27758085.43603455 1.0 0.4129303814741566 0.36489173193832325 26.180864361808464 -13.999999999999998 0.3547050027558555 8.432739407474747 0.3586623173192904 0.9997635700060348 0.004439695689689746 21.13729200040782 0.19206601304301196 118.63943362370982 0.014106906099225198 1.0000000000000041e-14 13.999999999999998 -8.074077090155457 ELLK(ub)PNASVALHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLKPNASVALHK 13 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 26040400.0 8836600.0 7673200.0 9530600.0 True False 12103729.820135936 7334172.652120821 7279668.568868316 1.0 0.6059431895050721 0.6014401078878806 23.52894835335103 ELLK(ub)PNASVALHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELLKPNASVALHK 13 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 39194500.0 13780000.0 18247000.0 7167500.0 True False 11458680.557507211 18148699.789254103 8666191.111224378 1.0 1.583838531685386 0.7562992150563688 23.449937594629922 -6.717105236564565 1.7694586896090743 1.3562809106449387 0.7577676852393564 0.4989930630592736 0.2457713521676361 0.36094826667226454 2.206965848809838 0.11034784309229484 0.2779905395488328 1.918203872582686e-07 6.717105236564565 -0.5985132254055823 ELLK(ub)PNASVALHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELLKPNASVALHK 13 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 127060000.0 50144000.0 52318000.0 24598000.0 True False 64912396.4860125 49406457.30878183 20121416.396793693 1.0 0.7611251468650995 0.30997802401471203 25.951990683900913 -6.961149747267183 0.4189154553902471 1.020175864922306 0.03393914184942785 0.9998104915099105 0.003938631878298569 0.07929294386280722 0.019632501263504007 0.00583207013847561 0.037565927958757836 1.0935792287679033e-07 6.961149747267183 -0.9862367230728782 down ELLKPNASVALHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLKPNASVALHK 13 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 57979000.0 20773000.0 20068000.0 17138000.0 False True 27233604.16601814 17073932.624451317 15364724.15930425 1.0 0.6269435554826792 0.5641825468872835 24.698884589243043 -13.999999999999998 0.25078485000071726 3.604730710066295 0.5391350633080517 0.9995441685943247 0.004107079796697514 14.02920487682579 0.15846385173858563 18.417239431856018 0.028837935923762565 1.0000000000000041e-14 13.999999999999998 -3.0655956467582435 ELLKPNASVALHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLKPNASVALHK 13 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 37074200.0 7479000.0 4309200.0 25286000.0 False True 7241583.238797623 6029886.032181131 18662838.03626015 1.0 0.8326750978812639 2.5771764848703014 22.78787371981665 -6.883369200659185 1.0607890480428954 0.8908329088313918 2.7091033963133087 0.9763047272534068 0.12097590785106188 0.12468930257007538 0.2545846258174342 0.08756398614429756 0.21369406056703583 1.30806943952291e-07 6.883369200659185 1.8182704874819169 up ELLKPNASVALHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELLKPNASVALHK 13 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 58100700.0 9492700.0 36093000.0 12515000.0 False True 14401119.909328852 29651922.154103875 10041404.764480634 1.0 2.059001129134114 0.6972655479367231 23.779677672046557 -6.6991469148678355 1.8339349648032395 1.6581459252844515 0.701383303799637 0.41352523137678965 0.44708750779058865 0.3972964463611555 2.59724007126744 0.19453269153960634 0.5008099547694814 1.9991854628060494e-07 6.6991469148678355 -0.9567626214848145 ELLKPNASVALHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLKPNASVALHK 13 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 46936000.0 20773000.0 11243000.0 14920000.0 False True 28453339.46921705 10746247.084370848 11396203.287045443 1.0 0.3776796427005323 0.40052252212344736 24.762094650765935 -10.091983996655813 5.106841012373867 1.0000140888644156 0.38910108241056396 0.9989524633273869 0.009325566478847032 1.4959440936947963e-06 2.6598367431398896e-07 0.009029648942965852 0.0030098136381349738 8.091257141524671e-11 10.091983996655813 -0.6109130064538516 ELLKPNASVALHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELLKPNASVALHK 13 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 17646900.0 7479000.0 5257900.0 4910000.0 False True 6219119.875877821 5229574.649088562 5936658.298725023 1.0 0.8408866131319609 0.9545817442354849 22.568278995250925 -10.473249667429622 4.636708858729191 1.0003692687678087 0.8977341786836812 0.5189389175842525 0.04641584290722119 0.00017781937901368373 2.020114697931949e-05 0.04510354871574413 0.014980648881633774 3.363181710314708e-11 10.473249667429622 -0.10263509008412752 ELLKPNASVALHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELLKPNASVALHK 13 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 35343200.0 9492700.0 15876000.0 9974500.0 False True 12288487.279091638 14992486.6438744 8159243.347012726 1.0 1.2200433058496554 0.6639745935934155 23.550803994139006 -6.799353241204849 1.4586333152393756 1.1215080086922973 0.6564278220751242 0.8302383071219446 0.09421042519375733 0.22168542531075358 0.9312528273710438 0.05081368759684927 0.11821648331917195 1.5872552009360955e-07 6.799353241204849 -0.4650801866171731 ELLLPNWQGSGSHGLTIAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLLPNWQGSGSHGLTIAQR 20 0 Q09666;E9PLK4;E9PQE3;E9PJZ0;E9PKR9;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 82676000.0 17304000.0 35165000.0 30207000.0 False True 22685711.572174363 29918519.07209638 27081469.40600445 1.0 1.3188265652109221 1.1937676858777397 24.435280576954938 -10.127173070147531 4.311780371123357 0.9999586822546824 1.2562971254640998 0.8484875445273755 0.05105507379242778 35634356.979902364 1.205805228130024 15632.988902950276 0.01747750972980671 7.461513513181721e-11 10.127173070147531 0.25633844320941734 ELLLPNWQGSGSHGLTIAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLLPNWQGSGSHGLTIAQR 20 0 Q09666;E9PLK4;E9PQE3;E9PJZ0;E9PKR9;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 109472000.0 41254000.0 22594000.0 45624000.0 False True 39944414.35129792 31615902.026153482 33673705.709338546 1.0 0.7914974481313476 0.8430141299153727 25.25149044143035 -10.118517588387556 4.976191546351999 1.0000075061648686 0.8172557890227423 0.943749481474386 0.021031597270840186 1.7514829670470955e-06 3.102565920646819e-07 0.020364592809560555 0.006787918830869339 7.611713118879773e-11 10.118517588387556 -0.18275171714212624 ELLLPNWQGSGSHGLTIAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELLLPNWQGSGSHGLTIAQR 20 0 Q09666;E9PLK4;E9PQE3;E9PJZ0;E9PKR9;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 109747000.0 20575000.0 56534000.0 32638000.0 False True 31213779.23398414 46445065.99784195 26187084.994256403 1.0 1.4879667613998717 0.8389591275684137 24.895679707532235 -6.705530640142769 1.8109404311933819 1.3013559301425768 0.8406660250072949 0.4438595815066374 0.20577736343978298 0.3841758283769817 2.4530284365498365 0.09051886133816128 0.23123230263766184 1.9700142147849846e-07 6.705530640142769 -0.46068990513528185 ELLLPNWQGSGSHGLTIAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLLPNWQGSGSHGLTIAQR 20 0 Q09666;E9PLK4;E9PQE3;E9PJZ0;E9PKR9;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 102610000.0 17304000.0 28306000.0 57000000.0 False True 23701756.423016995 27055347.324575365 43537773.95184924 1.0 1.1414912397927466 1.8369007416500704 24.49849063847783 -6.940189795780445 0.6578022570167844 0.9922189780118146 2.0254779823803717 0.9981885730223686 0.015567018452475625 0.0876802698628152 0.05421756345802178 0.01517514562564313 0.05980266725160363 1.1476519639533692e-07 6.940189795780445 1.0332590043685572 ELLLPNWQGSGSHGLTIAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELLLPNWQGSGSHGLTIAQR 20 0 Q09666;E9PLK4;E9PQE3;E9PJZ0;E9PKR9;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 83875000.0 41254000.0 20194000.0 22427000.0 False True 34304528.862075634 20085210.91380485 27116382.009268083 1.0 0.585497355015695 0.7904607032585077 25.031895716864625 -10.133464910594599 5.123763168780704 1.000011330865618 0.6879790291366729 0.7554992696851794 0.08367593652936967 1.083097789046962e-05 1.8318645484045261e-06 0.08102181788367968 0.027006292387832195 7.354194122732375e-11 10.133464910594599 -0.31203230172894514 ELLLPNWQGSGSHGLTIAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELLLPNWQGSGSHGLTIAQR 20 0 Q09666;E9PLK4;E9PQE3;E9PJZ0;E9PKR9;E9PJC6;Q09666-2 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 103288000.0 20575000.0 49716000.0 32997000.0 False True 26634743.09388378 46949260.89612363 26991884.57781131 1.0 1.762707480625362 1.013408857846635 24.666806029624684 -10.37935820438709 4.540847904357214 0.9994102650998847 1.3880581692367295 0.2634171878965833 0.30589988179883215 0.0018290157663436689 0.0002499894674261219 0.2966249524586953 0.09872876231745761 4.1748588388083485e-11 10.37935820438709 0.3886479041368448 ELLLQK(ub)LSTFEETNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLLQKLSTFEETNR 15 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9;Q5T4C6 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 38091700.0 13138400.0 14792300.0 10161000.0 True False 12721328.683596574 20698942.530825462 7499529.276534029 1.0 1.6271053948567153 0.5895240554710487 23.60074602548847 -6.743083605033886 1.6756031156818263 1.3717836816362776 0.5885155303236687 0.6186654164095473 0.26347056229270205 0.3122421105522968 1.7225051667285574 0.12433958079179654 0.3040683119646041 1.8068262645519714e-07 6.743083605033886 -0.783268151312609 ELLLQK(ub)LSTFEETNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELLLQKLSTFEETNR 15 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9;Q5T4C6 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 35916000.0 11059000.0 12609000.0 12248000.0 True False 16777311.521197088 10358825.435433337 9827177.431510897 1.0 0.6174305950238574 0.5857420850232691 24.00000821397096 -13.999999999999998 0.3529234130469977 5.790474726117314 0.5815319785352286 0.999760238753169 0.002915039465418808 20.954449064211936 0.19145100656345476 75.35915671212958 0.009361444023380338 1.0000000000000041e-14 13.999999999999998 -5.2089427475820855 ELLLQK(ub)LSTFEETNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELLLQKLSTFEETNR 15 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9;Q5T4C6 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 33668200.0 13138400.0 12957300.0 7572500.0 True False 10925161.729807895 12887496.453077322 9155874.738715937 1.0 1.1796160799995712 0.8380539313880648 23.381151300922745 -6.76385285014535 1.5983009154054388 1.10383156673534 0.836577378820797 0.7063735512209408 0.07559365208346752 0.2764911420898332 1.3929332278044741 0.03730498888480875 0.08930010082669752 1.7224520860607648e-07 6.76385285014535 -0.26725418791454303 ELLLQK(ub)LSTFEETNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELLLQKLSTFEETNR 15 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9;Q5T4C6 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 31814000.0 11059000.0 12832000.0 7923000.0 True False 14316093.50548045 12117887.91976544 6481095.296845133 1.0 0.8464521355023633 0.4527139540101535 23.77113453606341 -6.954915350712726 0.5019906173561905 1.0077511095768137 0.27437512162885247 0.9995326944790383 0.004982546091385569 0.0815699811805221 0.02824318546412866 0.005821597280169362 0.03248223165480866 1.1093910280219859e-07 6.954915350712726 -0.7333759879479612 down ELLLQPVTISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLLQPVTISR 11 0 F8WDD7;F8WCF6;A0A0A6YYG9;P59998;P59998-3;P59998-2;H7C0A3 F8WDD7 ARPC4;ARPC4-TTLL3 Actin-related protein 2/3 complex subunit 4 0 9208600.0 1615900.0 3749100.0 3843600.0 False True 2118460.54839786 3189748.893877337 3445901.1424146267 1.0 1.5056919026836098 1.6266062377327146 21.014584831299175 -11.674173878099817 0.24583318750517566 1.4844014586205504e-23 1.6836918525554143 0.9993327464084346 0.00701090781615524 4.367788420698073 0.14043103103489007 2.338189287531345 0.05690643063824812 2.1175131786227447e-12 11.674173878099817 1.6836918525554143 ELLLQPVTISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLLQPVTISR 11 0 F8WDD7;F8WCF6;A0A0A6YYG9;P59998;P59998-3;P59998-2;H7C0A3 F8WDD7 ARPC4;ARPC4-TTLL3 Actin-related protein 2/3 complex subunit 4 0 9909100.0 1615900.0 4019700.0 4273500.0 False True 2213341.898055547 3842096.362629674 3264187.31549522 1.0 1.7358801936587436 1.4747777188706617 21.077794892822066 -10.3521022365866 5.413452994484388 0.9998117966447613 1.6053289562647157 0.8775466785441216 0.10659463896816403 0.00024219858745099112 2.8986805747624075e-05 0.10324132806338156 0.03440327179321766 4.4452660983507024e-11 10.3521022365866 0.6055171596199544 ELLPLIYHHLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLPLIYHHLLR 12 0 A0A3B3IS06;E7ETY2;Q13428-2;Q13428-8;Q13428-6;Q13428-7;Q13428;Q13428-3;Q13428-4;H0Y8Y7;Q13428-5;A0A2R8Y4M7;A0A2R8Y857 A0A3B3IS06 TCOF1 Treacle protein 0 11922100.0 3496300.0 2474300.0 5951500.0 False True 4583683.158217362 2105144.0847458597 5335695.870819189 1.0 0.4592691100325901 1.1640629787540313 22.128075892243892 -6.7017031274892345 1.8245857109191617 0.664797005039008 1.1620504866555743 0.4257807835229682 0.22817790255941373 0.39197962871584796 2.538116465349278 0.09971922620242392 0.255933748843922 1.9874530247677188e-07 6.7017031274892345 0.49725348161656635 ELLPLIYHHLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLPLIYHHLLR 12 0 A0A3B3IS06;E7ETY2;Q13428-2;Q13428-8;Q13428-6;Q13428-7;Q13428;Q13428-3;Q13428-4;H0Y8Y7;Q13428-5;A0A2R8Y4M7;A0A2R8Y857 A0A3B3IS06 TCOF1 Treacle protein 0 34333000.0 10571000.0 12041000.0 11721000.0 False True 10235429.391272854 16849034.092985492 8650918.477537185 1.0 1.6461482414554751 0.8451935084338829 23.28706829101504 -6.691991559876488 1.859102152495114 1.4043252558105852 0.8478728269326506 0.37990128024194025 0.27316409102779804 0.4123843275406252 2.7648858677061154 0.11747134699513008 0.3051645595475863 2.032396508354652e-07 6.691991559876488 -0.5564524288779346 ELLPLIYHHLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLPLIYHHLLR 12 0 A0A3B3IS06;E7ETY2;Q13428-2;Q13428-8;Q13428-6;Q13428-7;Q13428;Q13428-3;Q13428-4;H0Y8Y7;Q13428-5;A0A2R8Y4M7;A0A2R8Y857 A0A3B3IS06 TCOF1 Treacle protein 0 21691500.0 3496300.0 9617000.0 8578200.0 False True 4788976.593954827 9192089.140833803 6552205.833574617 1.0 1.9194266166255791 1.368184977526416 22.191285953766783 -10.51289110789865 5.54109459977923 0.9987128259593245 1.643805797075905 0.6452283173440152 0.22504345679473423 0.0035846902467576635 0.0003151241081849998 0.21827376102881685 0.072632463361579 3.0697915909705204e-11 10.51289110789865 0.6450929711165805 ELLPLIYHHLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELLPLIYHHLLR 12 0 A0A3B3IS06;E7ETY2;Q13428-2;Q13428-8;Q13428-6;Q13428-7;Q13428;Q13428-3;Q13428-4;H0Y8Y7;Q13428-5;A0A2R8Y4M7;A0A2R8Y857 A0A3B3IS06 TCOF1 Treacle protein 0 20040000.0 10571000.0 4854400.0 4614600.0 False True 8790254.874703096 4828248.383677043 5579491.524500302 1.0 0.5492728541435068 0.6347360348511804 23.067473566449316 -10.06784883029576 5.203237678282906 1.0000057603805588 0.5920044444965317 0.968139935534314 0.03489019742440981 48418562.77001208 3.6087362705976065 3341.587948326312 0.011943842602781009 8.553643972592329e-11 10.06784883029576 -0.4080013158840271 ELLPLIYHHLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELLPLIYHHLLR 12 0 A0A3B3IS06;E7ETY2;Q13428-2;Q13428-8;Q13428-6;Q13428-7;Q13428;Q13428-3;Q13428-4;H0Y8Y7;Q13428-5;A0A2R8Y4M7;A0A2R8Y857 A0A3B3IS06 TCOF1 Treacle protein 0 24952100.0 2739100.0 12526000.0 9687000.0 False True 3545818.9457330224 11828917.088761054 7924065.397013608 1.0 3.3360183556455327 2.2347631163032995 21.757687441499368 -10.457282715278875 6.08926943182886 0.9991149224857087 2.7853907359744134 0.7780010708662186 0.4495855688258398 0.005403916441034544 0.00048163390359606275 0.435457567054425 0.14510311839647203 3.4891310747872024e-11 10.457282715278875 1.7862758134887047 ELLQESALIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLQESALIR 10 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 17650100.0 3279800.0 7826600.0 6543700.0 False True 4299849.561628377 6658901.787847859 5866620.695602719 1.0 1.5486359911917698 1.36437812800618 22.035854754606497 -10.099228884283896 4.549127731935789 0.9999635480859074 1.4565070596144114 0.8911185679114951 0.07522295770261238 39578686.90466451 0.8441725618600571 15112.284878408575 0.02752878370762981 7.957398646552086e-11 10.099228884283896 0.45654351152850403 ELLQESALIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLQESALIR 10 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 18042800.0 3279800.0 7578900.0 7184100.0 False True 4492430.693262315 7244039.137929211 5487363.541183856 1.0 1.6124988080047 1.2214687138999667 22.09906481612939 -10.420480315497077 5.858753073047247 0.9998321750951567 1.4169837609523337 0.6025754018731091 0.15963736743818194 0.00035008276410977436 3.4628340457264826e-05 0.15462962778998937 0.051522738793372574 3.797691517103269e-11 10.420480315497077 0.41715158585717704 ELLSAK(ub)DAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLSAKDAR 9 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 45092300.0 14236700.0 15637000.0 15218600.0 True False 18664451.56839893 13304020.552548617 13643925.25911939 1.0 0.7127999718499021 0.7310113136257446 24.15378978168319 -10.168156308799926 5.242300647625886 1.0000121176235293 0.721905642737685 0.9967939782280166 0.007434749147529475 1.052990238893238e-06 1.6708758160983305e-07 0.007198978413414869 0.0023995549692305486 6.789592214947958e-11 10.168156308799926 -0.2781064748858443 ELLSAK(ub)DAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLSAKDAR 9 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 59793400.0 10013000.0 20930600.0 28849800.0 True False 9695142.795839088 29288297.73163708 21293171.904551845 1.0 3.020924843335663 2.19627212852299 23.20883071668479 -10.527674456283698 6.105155070895801 0.9978970685121504 2.6085984859292313 0.8353452873738247 0.33666306104865756 0.009640658603112199 0.0007458490524602062 0.326112080636063 0.108657535727055 2.967054636896536e-11 10.527674456283698 1.6107014174170808 ELLSAK(ub)DAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELLSAKDAR 9 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 79202700.0 32679300.0 7163800.0 39359600.0 True False 49576887.276847556 5885363.918975126 31580157.80807448 1.0 0.11871184824714874 0.6369935577383947 25.563164357757408 -10.405101412554078 9.52838655163181 1.0000013349635413 0.3778527033148448 0.6576857265396712 0.21158762187848965 6.000498591572534e-06 3.746957167013718e-07 0.20486927337455216 0.0682896113165852 3.934581878990268e-11 10.405101412554078 -0.6221486316486965 ELLSAK(ub)DAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLSAKDAR 9 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 44467200.0 14236700.0 10838000.0 19392500.0 True False 19500392.72235127 10359141.323526734 14812390.901074314 1.0 0.5312273178813024 0.7595944918635619 24.216999843206082 -10.144833591209249 5.010778419885984 1.0000183939765757 0.6454109048716857 0.7627275548414355 0.09323050837891154 1.9158549562962864e-05 3.2697554295764394e-06 0.09027472995492827 0.030090017192127165 7.164178677491585e-11 10.144833591209249 -0.35460748910488993 ELLSAK(ub)DAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELLSAKDAR 9 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 57860400.0 10013000.0 26925800.0 20921600.0 True False 8326253.151111723 26780745.371047154 25296209.829451222 1.0 3.216422187148055 3.0381264381895075 22.989235992119067 -10.164813518670694 4.729233992934588 0.9997725931615715 3.1272743126686837 0.9947590003244617 0.07278893505658159 4536897.61566013 9751458.21925809 7319.565428536713 0.024917589927891913 6.842053745650934e-11 10.164813518670694 2.127501719507112 ELLSAK(ub)DAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELLSAKDAR 9 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 82822000.0 32679300.0 22875000.0 27267700.0 True False 42303998.05530774 21601986.141258933 22305258.390228953 1.0 0.5106369878567212 0.5272612380765366 25.334290679849857 -9.871529687922456 6.830427301615977 1.0000000094244477 0.5189491129859928 0.9991050993001317 0.0067868217325154955 9.721064506285195e-10 1.576946718501514e-10 0.006571311983833416 0.002190437295304463 1.344219874047563e-10 9.871529687922456 -0.4810508964384549 ELLSNVDEGIYQLEK(ub)GAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLSNVDEGIYQLEKGAR 18 1 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 1 9884800.0 1744200.0 5314600.0 2826000.0 True False 1688831.3257268097 7436747.495272879 2085785.8218172572 1.0 4.403487418776047 1.2350468575774511 20.687593813574022 -6.629244108236613 2.083042749701587 3.2435089803577553 1.2477355762971725 0.114790790937505 1.4601961700698567 0.5610119105174681 4.637850381969324 0.5735087972445471 1.617789701300043 2.3483125103584202e-07 6.629244108236613 -1.9957734040605828 ELLSNVDEGIYQLEK(ub)GAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELLSNVDEGIYQLEKGAR 18 1 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 1 7799300.0 1744200.0 3029100.0 3026000.0 True False 1450379.5811613975 3012781.637070725 3658722.6093568103 1.0 2.0772366601150214 2.522596606349817 20.4679990890083 -9.840543760819157 0.2266085769168473 6.152236350353858e-18 2.840502072730946 0.9992489554411835 0.017517147720808375 1.2911197290239038 0.0992815927862885 1.062118695483017 0.22507567052102356 1.4436311323437572e-10 9.840543760819157 2.840502072730946 ELLSNWYHFLVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLSNWYHFLVTR 13 0 J3KT10;Q9BW27;Q9BW27-3;J3QL54;J3QLD4;Q9BW27-2;J3KTC7;J3QLV0 J3KT10 NUP85 Nuclear pore complex protein Nup85 0 2545740.0 978610.0 771150.0 795980.0 False True 1282967.1868727207 656097.4259191572 713619.6251793099 1.0 0.5113906517893249 0.5562259366264727 20.29105284190191 -10.064670120100185 7.6929548463521025 1.000000029724531 0.5338082950206267 0.9931107842500595 0.018303928387226016 9.32803539103515e-09 1.1328460109819294e-09 0.01772270377391419 0.0059075674844916255 8.616479912805459e-11 10.064670120100185 -0.4661917347039044 ELLSNWYHFLVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLSNWYHFLVTR 13 0 J3KT10;Q9BW27;Q9BW27-3;J3QL54;J3QLD4;Q9BW27-2;J3KTC7;J3QLV0 J3KT10 NUP85 Nuclear pore complex protein Nup85 0 26259600.0 8353900.0 6227700.0 11678000.0 False True 8088710.017193662 8714453.087026464 8619181.467509545 1.0 1.0773600572282476 1.065581711940259 22.94747821015132 -10.066508890490406 4.095283941789114 0.9999903241416725 1.0714708846078926 0.9800375032095189 0.004808489468444659 3336025.270038633 0.0446863573352897 338.0177497191497 0.0016460738223733802 8.58007550175299e-11 10.066508890490406 0.07148056046622009 ELLSNWYHFLVTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELLSNWYHFLVTR 13 0 J3KT10;Q9BW27;Q9BW27-3;J3QL54;J3QLD4;Q9BW27-2;J3KTC7;J3QLV0 J3KT10 NUP85 Nuclear pore complex protein Nup85 0 30661200.0 10450000.0 6983200.0 13228000.0 False True 15853413.997333363 5736993.400009365 10613480.001961628 1.0 0.36187747326691655 0.66947598818443 23.91829021919149 -10.526255711833093 6.378643284555143 1.0004605634958086 0.5156767307257683 0.7677404888794394 0.12557656786429794 0.0008232298756745928 6.11413638625835e-05 0.12169902088547259 0.04052966300102592 2.976763200352869e-11 10.526255711833093 -0.48478383277004033 ELLSNWYHFLVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLSNWYHFLVTR 13 0 J3KT10;Q9BW27;Q9BW27-3;J3QL54;J3QLD4;Q9BW27-2;J3KTC7;J3QLV0 J3KT10 NUP85 Nuclear pore complex protein Nup85 0 4534610.0 978610.0 1767100.0 1788900.0 False True 1340428.5629408613 1689023.6789817426 1366398.663551984 1.0 1.2600624350141225 1.0193744756931655 20.3542629034248 -10.769351822317965 2.8564855178550608 0.969357964063995 1.1397184553534618 0.31001227779247476 0.09826044883155749 73507189.9013246 74004487.28805381 16012787.98766151 0.035959640486457584 1.7007801467648073e-11 10.769351822317965 0.17036049128946684 ELLSNWYHFLVTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELLSNWYHFLVTR 13 0 J3KT10;Q9BW27;Q9BW27-3;J3QL54;J3QLD4;Q9BW27-2;J3KTC7;J3QLV0 J3KT10 NUP85 Nuclear pore complex protein Nup85 0 26044500.0 8353900.0 8304900.0 9385700.0 False True 6946637.990519546 8260159.855306419 11348206.475426383 1.0 1.1890874213654874 1.6336257180687834 22.727883485585597 -6.956764936201432 0.4788538665985291 0.9892138849621512 1.851997373927531 0.999630763058339 0.005103481773134957 0.08087764357979728 0.02555985549056039 0.00625336291951532 0.03667221392459356 1.1046763690639582e-07 6.956764936201432 0.8627834889653798 ELLTEFGYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLTEFGYK 9 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 28963500.0 5475000.0 7947500.0 15541000.0 False True 7177778.019975424 6761763.979112361 13932966.399798535 1.0 0.9420413894515385 1.9411252843183133 22.77510587636886 -6.893140970819418 1.0036388724259682 0.9502898895855683 2.0325285654275853 0.9828329830565912 0.05999848169366315 0.11663083969688028 0.2072677890166811 0.04535263588496084 0.11441875340802683 1.2789660878238343e-07 6.893140970819418 1.082238675842017 ELLTEFGYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLTEFGYK 9 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 20360400.0 5475000.0 5499500.0 9385900.0 False True 7499255.456311729 5256513.90558547 7169143.728678262 1.0 0.7009381046169508 0.9559807330798914 22.83831593789175 -10.110204703052988 6.829011966493023 1.0000001438614239 0.8284594193888326 0.3762397264277466 0.10412071706540593 2.2800825468581747e-07 2.9697474649369567e-08 0.10081453492304329 0.033604816932457586 7.758813217161204e-11 10.110204703052988 -0.17154072447259128 ELLTLDEK(ub)DPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLTLDEKDPR 11 1 P46781;B5MCT8;C9JM19;F2Z3C0;A8MXK4 P46781 RPS9 40S ribosomal protein S9 1 77439000.0 17862100.0 17111100.0 42465800.0 True False 23417386.076822437 14558190.578545408 38071846.37671741 1.0 0.6216829893305003 1.625794025508225 24.481076710824855 -6.804627768292845 1.4367571481272832 0.7924636908001197 1.6413175660534323 0.8453627394046064 0.16282312784089167 0.21424047548098632 0.8725345109162131 0.08912964336943789 0.20674414858894571 1.5680945005402845e-07 6.804627768292845 0.8488538752533126 ELLTLDEK(ub)DPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLTLDEKDPR 11 1 P46781;B5MCT8;C9JM19;F2Z3C0;A8MXK4 P46781 RPS9 40S ribosomal protein S9 1 55993200.0 16024600.0 14205000.0 25763600.0 True False 15515907.844422579 19877130.57809641 19015340.2685673 1.0 1.281080731943219 1.2255383609669122 23.88724477643935 -10.07798830064914 4.471769590496898 0.9999813388398411 1.2533095464190873 0.9651965134314617 0.022675078053451782 1955215.8837729646 4415995.765460786 205.25680305930172 0.008298228664529148 8.356255286359958e-11 10.07798830064914 0.25332820757924623 ELLTLDEK(ub)DPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELLTLDEKDPR 11 1 P46781;B5MCT8;C9JM19;F2Z3C0;A8MXK4 P46781 RPS9 40S ribosomal protein S9 1 321440500.0 25927500.0 72916000.0 222597000.0 True False 39333913.05414932 59903570.10469166 178600605.38226914 1.0 1.522949675060932 4.540626434405275 25.2292703812068 -6.9366656461174685 0.6898830208359628 0.9633930340170198 5.280334602624659 0.9976937832951973 0.07493907127887917 0.08932118441370573 0.061786156651700876 0.071221493686812 0.2637658069134563 1.1570026505891308e-07 6.9366656461174685 4.316941568607639 up ELLTLDEK(ub)DPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLTLDEKDPR 11 1 P46781;B5MCT8;C9JM19;F2Z3C0;A8MXK4 P46781 RPS9 40S ribosomal protein S9 1 56371800.0 17862100.0 8903000.0 29606700.0 True False 24466201.07510238 8509636.021716064 22614207.229126573 1.0 0.34781190572228854 0.9243039881716472 24.544286772347746 -10.51036196540716 8.961505454333285 1.0000148983551553 0.6360579469469867 0.3470001200277685 0.23535190712590304 7.00578297422947e-05 3.827739606440055e-06 0.22788781072402423 0.0759595013997314 3.087720879815288e-11 10.51036196540716 -0.36395695140816864 ELLTLDEK(ub)DPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELLTLDEKDPR 11 1 P46781;B5MCT8;C9JM19;F2Z3C0;A8MXK4 P46781 RPS9 40S ribosomal protein S9 1 43669300.0 16024600.0 13653700.0 13991000.0 True False 13325164.91014732 13580144.808052743 16916453.412925042 1.0 1.0191352151830595 1.2695117491598846 23.667650051873625 -6.9221821206569265 0.8083642423530942 0.99489805913669 1.3119876860452164 0.9947662025414166 0.008883065586774513 0.09690479794068586 0.09908110848875845 0.007743484866560039 0.023702711877107725 1.1962387853987142e-07 6.9221821206569265 0.3170896269085264 ELLTLDEK(ub)DPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELLTLDEKDPR 11 1 P46781;B5MCT8;C9JM19;F2Z3C0;A8MXK4 P46781 RPS9 40S ribosomal protein S9 1 369784500.0 25927500.0 61019000.0 282838000.0 True False 33563659.85743234 57623239.009988114 231364386.16295373 1.0 1.7168341967101663 6.893300288041155 25.00039670329925 -6.932052971759719 0.7297427187999127 0.9269671884520658 8.01378453003607 0.9969265688709928 0.14555550153008587 0.091585862681009 0.07255989702882538 0.13426556734209588 0.46320712728298596 1.1693567535576008e-07 6.932052971759719 7.086817341584004 ELLTLDEKDPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLTLDEKDPR 11 1 P46781;B5MCT8;C9JM19;F2Z3C0;A8MXK4 P46781 RPS9 40S ribosomal protein S9 0 20767100.0 1375000.0 13420000.0 5972100.0 False True 1802638.31551894 11417788.310750278 5354164.380428348 1.0 6.333931888862213 2.970182279126249 20.781678530292343 -9.528237507555179 9.509028237820434 0.9998690275578825 4.652057083995207 0.6111504461335451 1.3732450298051013 0.0 0.0 1.3296387817336104 0.4432129272445367 2.963210421792558e-10 9.528237507555179 3.652188056437325 ELLTLDEKDPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLTLDEKDPR 11 1 P46781;B5MCT8;C9JM19;F2Z3C0;A8MXK4 P46781 RPS9 40S ribosomal protein S9 0 15823900.0 7403800.0 1596800.0 6823300.0 False True 7168770.421635218 2234410.567201992 5036073.035387725 1.0 0.3116867239127343 0.7025016480077181 22.773294260255586 -10.750683589442222 6.945026961416171 1.0091464959756749 0.5070941859609196 0.6795816872372824 0.15954952464954153 0.022532746592958487 0.0008088917324245981 0.15405266485898392 0.05149438765524868 1.7754825593280638e-11 10.750683589442222 -0.5020523100147553 ELLTLDEKDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLTLDEKDPR 11 1 P46781;B5MCT8;C9JM19;F2Z3C0;A8MXK4 P46781 RPS9 40S ribosomal protein S9 0 14835800.0 1375000.0 5977400.0 7483400.0 False True 1883374.6579778292 5713298.703381502 5715975.045460844 1.0 3.033543368113408 3.0349644035234395 20.844888591815234 ELLTSFGPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLTSFGPLK 10 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 13006600.0 1429700.0 5112300.0 6464600.0 False True 1874350.5452344944 4349564.767589319 5795705.204821939 1.0 2.3205716660888305 3.092113809531213 20.83795936361108 -8.74455229402033 0.20476535890036784 5.544695043519514e-23 3.9157669406976714 0.99960258108605 0.017221161391293607 0.2933906746395531 0.06074895088195163 0.5814534515903639 0.3884575538872703 1.8007262933560898e-09 8.74455229402033 3.9157669406976714 ELLTSFGPLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLTSFGPLK 10 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 7941200.0 3415200.0 1413400.0 3112600.0 False True 3306786.3453859626 1977777.9907836278 2297316.6840015585 1.0 0.5980966969768907 0.694727885037707 21.656998403964266 -10.186619320862597 6.209479247744542 1.0000031464925847 0.6464122910073024 0.9469565639097355 0.039449517331324103 1.7184376515539198e-06 2.2503574039101115e-07 0.03819717120145441 0.012732276970011043 6.506998088232681e-11 10.186619320862597 -0.35359085548528235 ELLTSFGPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLTSFGPLK 10 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 13325900.0 1429700.0 4368800.0 7527400.0 False True 1958298.726189748 4175771.970310351 5749583.151669288 1.0 2.132346773484927 2.9360092384149294 20.901169425133972 -7.90603546077124 0.16833931853101414 3.6574970541293095e-20 4.327068203297972 0.9999303215478298 0.006629140464728915 0.1201082165616081 0.0268331457317501 0.259111493991958 0.3479995831291338 1.2415509290283992e-08 7.90603546077124 4.327068203297972 ELLTTMGDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLTTMGDR 9 0 J3QRS3;P19105;O14950;P24844;P24844-2 J3QRS3 MYL12A;MYL12B;MYL9 Myosin regulatory light chain 12A;Myosin regulatory light chain 12B;Myosin regulatory light polypeptide 9 0 7246090.0 2112300.0 752890.0 4380900.0 False True 2045246.192714562 1053522.9032694835 3233410.8658171357 1.0 0.5151081112006328 1.5809396821443666 20.96384308468211 -6.783010443343723 1.524061068663615 0.726513264753441 1.5902046944040922 0.7779124838094682 0.20533455239963588 0.24593134348097043 1.1284553655771608 0.10609301442745585 0.24972098827576356 1.648122759155919e-07 6.783010443343723 0.8636914296506512 ELLVPLTSSMYVPGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELLVPLTSSMYVPGK 15 0 Q99471 Q99471 PFDN5 Prefoldin subunit 5 0 7238200.0 1080500.0 3405100.0 2752600.0 False True 1416545.9635768852 2897072.3529758453 2467787.3568036472 1.0 2.0451665018059275 1.7421159780599695 20.433945983852468 -10.163232540633656 4.6696751826043315 0.9999075293129283 1.8936412398569946 0.9205974064998408 0.12371985871469554 86658878.62810634 21.966986813480208 103047.59695492515 0.04235259831836963 6.867006514045507e-11 10.163232540633656 0.8937337105440664 ELLVPLTSSMYVPGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELLVPLTSSMYVPGK 15 0 Q99471 Q99471 PFDN5 Prefoldin subunit 5 0 6108700.0 2155200.0 1490500.0 2463000.0 False True 2086784.3556968379 2085664.4228548151 1817866.411583832 1.0 0.9994633212392237 0.8711328540589877 20.992850092178934 -6.907817292141412 0.9104700013693662 1.0042528263537234 0.8552998494838275 0.9900714842584061 0.006040536121391765 0.10587914046605651 0.1467274058597425 0.004892704397635556 0.013310307234216025 1.2364675064034832e-07 6.907817292141412 -0.14895297686989584 ELLVPLTSSMYVPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELLVPLTSSMYVPGK 15 0 Q99471 Q99471 PFDN5 Prefoldin subunit 5 0 7597300.0 1080500.0 3066300.0 3450500.0 False True 1479990.0494145795 2930820.7271018694 2635562.9652781724 1.0 1.9802975893393175 1.7807977603097318 20.49715604537536 -10.181404520571842 4.992919202257009 0.9999279604547635 1.8805476748258552 0.962928955863413 0.08144546415377593 6.531758462432329e-05 1.0708853554119828e-05 0.07886562666848647 0.026286410523648843 6.585601981647191e-11 10.181404520571842 0.8806197143710917 ELMGDHVSSTK(ub)ATVWEGSNR ddPTM_RPMI8226_Bortezomib_1h_R1 2 ELMGDHVSSTKATVWEGSNR 20 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 1107952800.0 358123000.0 455416600.0 294413200.0 True False 469502721.06806546 387470218.4800033 263950146.27483216 1.0 0.8252778974284802 0.5621908764966803 28.80655827834116 -6.965193606969084 0.3547138508092303 1.0240841764424158 0.3544424339834799 0.9999170800189088 0.0016385696002679934 0.07789533158388974 0.01462863109018203 0.003570298819963492 0.022544132298373726 1.0834438108648631e-07 6.965193606969084 -0.6696417424589358 ELMGDHVSSTK(ub)ATVWEGSNR ddPTM_RPMI8226_Bortezomib_2h_R1 2 ELMGDHVSSTKATVWEGSNR 20 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 1046877900.0 374041000.0 337933900.0 334903000.0 True False 362167273.19469213 472872668.57200754 247181857.42535943 1.0 1.3056747629369674 0.6825074370882777 28.432080943893574 -6.773339428602277 1.5618212923054027 1.174578303046503 0.6785637417755372 0.7431203637107717 0.12894957564720852 0.26106178516960465 1.2572131535501039 0.06506316180954391 0.154398259081306 1.6852353925160066e-07 6.773339428602277 -0.49601456127096566 ELMGDHVSSTK(ub)ATVWEGSNR ddPTM_RPMI8226_Bortezomib_8h_R1 2 ELMGDHVSSTKATVWEGSNR 20 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 2514654700.0 684452000.0 768331700.0 1061871000.0 True False 1038363724.1438094 631216905.1320283 851991731.4154078 1.0 0.6078957598913646 0.8205137675797793 29.951664741904366 -10.075541534309567 5.088756787986069 1.0000056456076518 0.714204763734652 0.7066644845829622 0.08680093816382714 5.559790330015565e-06 1.0100502651772927e-06 0.08404630726298917 0.028014882328181206 8.403466356289167e-11 10.075541534309567 -0.2858008818729998 ELMGDHVSSTK(ub)ATVWEGSNR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ELMGDHVSSTKATVWEGSNR 20 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 1047320500.0 358123000.0 361324300.0 327873200.0 True False 490530751.010178 345359797.6863231 250436302.9205168 1.0 0.7040533075145726 0.5105414949109286 28.869768339864052 -8.49390535860837 0.1163334824668292 1.5108285857360801 8.286276338737549e-11 0.9999628808705803 0.0012262575316281728 0.14834669562543226 0.02823451339891645 0.18122008847858068 0.16203174544184845 3.20696811039682e-09 8.49390535860837 -1.5108285856532173 ELMGDHVSSTK(ub)ATVWEGSNR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ELMGDHVSSTKATVWEGSNR 20 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 1201453400.0 374041000.0 552500300.0 274912100.0 True False 311031664.3258747 549523871.2211775 332394949.06006646 1.0 1.7667779015754141 1.068685240714942 28.21248621932785 -10.364407707897268 6.196422284224627 0.9999518703640322 1.417731571145089 0.32314771544440435 0.28499513538165744 0.00018955200531443954 1.9443118808811378e-05 0.2759770229477427 0.09198178442360716 4.3210798531111184e-11 10.364407707897268 0.41777970078105686 ELMGDHVSSTK(ub)ATVWEGSNR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ELMGDHVSSTKATVWEGSNR 20 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 2650154700.0 684452000.0 816353700.0 1149349000.0 True False 886036606.5659739 770922898.9624239 940179275.3166295 1.0 0.8700801899712722 1.0611065822218082 29.722791063996816 -6.723610263748004 1.7466513432252722 0.9212620258121973 1.060863905004285 0.5293221835404311 0.05464807143897729 0.3483643462334603 2.0789637783910644 0.024825999508125758 0.06205179191120198 1.88968639465598e-07 6.723610263748004 0.13960187919208766 ELMNLTGTIPVPYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELMNLTGTIPVPYR 14 0 F5H442;Q99816 F5H442 TSG101 Tumor susceptibility gene 101 protein 0 3216880.0 502880.0 1670600.0 1043400.0 False True 659280.5498968466 1421352.991947798 935438.976999536 1.0 2.155915250601869 1.418878468575932 19.330532994016984 -10.141500020129966 4.774440613602989 0.9999505760709094 1.7873968595892036 0.6034524415984621 0.3008940063880071 210308835.37472698 18.465334686503244 144985.7895500058 0.10300402167950751 7.219381294746336e-11 10.141500020129966 0.7874462835182942 ELMSATEK(ub)AR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELMSATEKAR 10 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 4052400.0 1204900.0 1615600.0 1231900.0 True False 1166651.1090289154 2260717.5052427016 909228.4337921727 1.0 1.9377837022110693 0.7793490502477528 20.153941752023634 -6.691305578062038 1.861536893921456 1.5871944994981606 0.7832573449393199 0.3766882420119253 0.39650942281290535 0.4138468691867389 2.7814362293890853 0.1703249582939685 0.4428487014216723 2.0356092793286346e-07 6.691305578062038 -0.8039371545588407 ELMSATEK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELMSATEKAR 10 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 4327990.0 1204900.0 2594800.0 528290.0 True False 1001927.736120496 2580821.2973725274 638752.9964630242 1.0 2.575855727245929 0.6375240183850995 19.93434702745791 -6.690463138540789 1.8645158698722584 1.9875119539095478 0.6441367661623554 0.372720354243412 0.6664104082637577 0.41566775646942394 2.801966705667948 0.28587452342200664 0.7440725864066909 2.0395617634250543e-07 6.690463138540789 -1.3433751877471924 ELMTHHVHTYGLIMGGSNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELMTHHVHTYGLIMGGSNR 19 0 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 21487900.0 7203300.0 8289800.0 5994800.0 False True 9443596.056856427 7052994.153387305 5374515.602182116 1.0 0.7468547056570204 0.5691174812882857 23.170904901950284 -7.634253209001087 0.10919435725814677 1.4289430689850349 1.038537915807789e-11 0.999994052853956 0.0004311260817743156 0.1375073510576714 0.011718444901879354 0.06146233642922067 0.08488020638956259 2.3213829535862454e-08 7.634253209001087 -1.4289430689746494 ELMTHHVHTYGLIMGGSNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELMTHHVHTYGLIMGGSNR 19 0 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 14841700.0 7203300.0 3549200.0 4089200.0 False True 9866554.671863059 3392384.6083651185 3123415.1797175747 1.0 0.34382666707755133 0.3165659425802172 23.234114963473175 -13.436973733970888 0.45949124023463545 9.999999944474242 0.31688663563584246 0.9999000148238719 0.0031592061680280874 21.889880763287437 0.23185164151393572 196.83793915800527 0.006027758128648448 3.6561690336961976e-14 13.436973733970888 -9.683113308838399 ELMTHHVHTYGLIMGGSNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELMTHHVHTYGLIMGGSNR 19 0 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 9298500.0 4414000.0 2539900.0 2344600.0 False True 3670436.573355355 2526217.0545693203 2834845.01979444 1.0 0.6882606480405576 0.7723454589498455 21.80752024131788 -9.954294905960055 6.553530465881793 1.0000000378282141 0.7303030534951972 0.932050864717482 0.034327480307711086 1.895667943973642e-08 3.09853444778132e-09 0.03323744434472682 0.011079146629083145 1.1109770664778375e-10 9.954294905960055 -0.2696969843330169 ELMVQK(ub)QQEALEEQAALEPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELMVQKQQEALEEQAALEPK 20 1 Q96JB5;Q96JB5-4;Q96JB5-2;J3QRM1;Q96JB5-3 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 4742800.0 2375700.0 2367100.0 0.0 True False 2300284.7038924317 3312295.374263429 0.0 1.0 1.4399501803661614 0.0 21.133381002439126 -6.849222287584198 1.4079787122437595 1.2342339735811583 1.1242259413732143e-21 0.8940547769187792 0.19610778987766136 0.1753316750417398 0.6983994818618644 0.11197482590641457 0.23677556631265584 1.4150693110423499e-07 6.849222287584198 -1.2342339735811583 down ELNEDK(ub)LEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELNEDKLEK 9 1 A0A494C128;O00567;Q5JXT2 A0A494C128 NOP56 Nucleolar protein 56 1 18921700.0 4644000.0 3510700.0 10767000.0 True False 7045287.521877152 2884188.1557757016 8638897.730656246 1.0 0.40937834642229565 1.2261951983975938 22.74822715420145 -6.712692289429297 1.7852996604833768 0.6379121759328571 1.2244599536025762 0.4780386313942445 0.24878167490388145 0.36968013993378673 2.2984089400824046 0.11081770694683887 0.28064622674451123 1.9377944627319738e-07 6.712692289429297 0.5865477776697191 ELNGK(ub)QIYVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELNGKQIYVGR 11 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 22120900.0 8451200.0 10129000.0 3540700.0 True False 11079605.041537216 8617792.68253277 3174342.328792663 1.0 0.7778068487301524 0.2865032026766403 23.40140311827269 -6.95803574054937 0.4622899752054889 1.0139977986293767 0.03043077435640567 0.9996902520941978 0.005246632365044637 0.08041046569313537 0.02378190088520359 0.006698811155196866 0.040576841099638515 1.1014486613711383e-07 6.95803574054937 -0.983567024272971 down ELNGK(ub)QIYVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELNGKQIYVGR 11 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 21284900.0 8081200.0 8248800.0 4954900.0 True False 7824666.729425238 11542588.856923724 3657063.046186249 1.0 1.4751540552541316 0.46737620561315313 22.899597874973942 -6.778484092093634 1.5416544483848837 1.2695750123613376 0.459752946352747 0.7620220311498588 0.2008134600619996 0.25294139217012895 1.1872940704994717 0.10260257788379376 0.24241995533501484 1.6653898287448816e-07 6.778484092093634 -0.8098220660085906 down ELNGK(ub)QIYVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELNGKQIYVGR 11 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 64203000.0 21173000.0 18959000.0 24071000.0 True False 32120988.953640115 15575618.322656877 19313356.299305927 1.0 0.4849046940969658 0.601269043340499 24.93701297601285 -10.102827386308364 6.533593235884346 1.000000628163498 0.5430868687188031 0.9536120061063218 0.04750554664961575 4.346733866489705e-07 5.969135463954296e-08 0.04599711081014254 0.015332349252202953 7.891737184743542e-11 10.102827386308364 -0.45691375944469503 ELNGK(ub)QIYVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELNGKQIYVGR 11 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 19921500.0 8451200.0 6690900.0 4779400.0 True False 11575837.025092535 6395273.914152531 3650604.1548327776 1.0 0.5524675149010582 0.3153641630336961 23.46461317979558 -9.645491651475265 0.1642642485118868 1.5985030729277623 4.2770522612554103e-11 0.9996991000222821 0.004924104619255696 1.1000621070584788 0.06796719569822221 0.47935347208409457 0.1753362324905826 2.2620820237810495e-10 9.645491651475265 -1.5985030728849918 ELNGK(ub)QIYVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELNGKQIYVGR 11 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 61176000.0 21173000.0 22728000.0 17275000.0 True False 27408865.88222603 21463166.820482336 14131127.25646847 1.0 0.7830738751726559 0.5155677479392591 24.708139298105298 -6.968307658427047 0.29582856245312217 1.0487556029877252 0.24155331006691794 0.9999660084831545 0.0011551142155642054 0.07685575179920939 0.01098524834674235 0.004532463996080057 0.024099690615886238 1.0757029052675353e-07 6.968307658427047 -0.8072022929208073 ELNGTAPEEK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELNGTAPEEKK 11 1 Q9Y263;E5RIM3;H0YC16 Q9Y263 PLAA Phospholipase A-2-activating protein 1 1779080.0 434820.0 587570.0 756690.0 True False 421016.87710843474 822189.7651370707 558490.1887865893 1.0 1.9528665235083014 1.3265268428722579 18.683518541535165 -10.48978493944707 5.0428822304863985 0.99828990736822 1.6396966831903006 0.581731309030155 0.2557021038694196 0.004927437319733402 0.0004985349866935513 0.24814561260416795 0.08252749915636132 3.237539386449143e-11 10.48978493944707 0.6414067758220806 ELNGTAPEEK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELNGTAPEEKK 11 1 Q9Y263;E5RIM3;H0YC16 Q9Y263 PLAA Phospholipase A-2-activating protein 1 2145580.0 373960.0 620220.0 1151400.0 True False 567324.660138066 509536.895199022 923825.285323453 1.0 0.8981398676994217 1.6283890869447273 19.1138150500368 -6.871611677169804 1.125593975836282 0.9417954194365692 1.6724756398574168 0.9662624424501268 0.059313770996888615 0.13531588346677423 0.31944595169451234 0.04085604250894315 0.0970040397269237 1.343966126469082e-07 6.871611677169804 0.7306802204208476 ELNGTAPEEK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELNGTAPEEKK 11 1 Q9Y263;E5RIM3;H0YC16 Q9Y263 PLAA Phospholipase A-2-activating protein 1 1532070.0 434820.0 758340.0 338910.0 True False 361572.0957921106 754254.6719012946 409774.5140572096 1.0 2.0860422601166677 1.133313435483731 18.46392381696944 -6.614508288507493 2.136617657085443 1.7233531151310313 1.1368018705801513 0.0647889599069339 0.46768636149133935 0.600284086003878 5.199184401960645 0.18032834968416758 0.5190125033717888 2.429359077275067e-07 6.614508288507493 -0.58655124455088 ELNITAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELNITAAK 8 0 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 0 21523800.0 3599000.0 8721800.0 9203000.0 False True 4718323.8527655825 7420541.437310119 8250761.841409559 1.0 1.57270710296002 1.7486637413778805 22.16984301391769 -11.29969737061517 0.21680748034145245 1.530957652398188e-09 1.862696178715438 0.9993300482258926 0.008273034546003479 3.616116787394057 0.1232538547689016 1.834798887819639 0.09838115585375107 5.015365975917724e-12 11.29969737061517 1.8626961771844803 ELNITAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELNITAAK 8 0 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 0 10749500.0 3599000.0 7150500.0 0.0 False True 4929647.559317977 6834567.266458563 0.0 1.0 1.386421074573561 0.0 22.23305307544058 -6.860857637138316 1.3816835732228807 1.203918135844152 1.9491796826263674e-20 0.9095275019514482 0.17571596022107622 0.16467481205456475 0.6320291708936648 0.10257413721263664 0.21380865591803952 1.3776609957446736e-07 6.860857637138316 -1.203918135844152 down ELNITAAK(ub)EIEVGGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELNITAAKEIEVGGGR 16 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 1 34502000.0 9817900.0 2708500.0 21975600.0 True False 12871361.976678833 2304402.357650308 19701775.716840185 1.0 0.17903329591892242 1.5306675200757416 23.617661383895896 -6.742291125458521 1.6783354847896372 0.5128317510525349 1.531860187074574 0.6151884318043819 0.34492218349596376 0.3136782454229744 1.7357554879576822 0.1625267348304744 0.3978231501173233 1.810126283713688e-07 6.742291125458521 1.0190284360220392 ELNITAAK(ub)EIEVGGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELNITAAKEIEVGGGR 16 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 1 70656000.0 18857900.0 17968700.0 33829400.0 True False 18259266.286792573 25143695.6155326 24968465.279753964 1.0 1.3770375666036332 1.3674407770598285 24.122125458795836 -10.087919364300605 4.586568927540849 0.999975593732718 1.372239171843544 0.9995017428192363 0.0039178729655075205 2723916.162592137 0.06616725805683096 702.0997506859809 0.0013411921193789871 8.167340007403909e-11 10.087919364300605 0.372263578110826 ELNITAAK(ub)EIEVGGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELNITAAKEIEVGGGR 16 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 1 199636900.0 33587800.0 40582100.0 125467000.0 True False 50955148.19709409 33339907.18560548 100668392.45586038 1.0 0.6542990917551058 1.9756275080679948 25.602724579065846 -6.83718523075421 1.2953509287408844 0.8159752344538687 2.0167356255186584 0.9195180329209046 0.1587237938256698 0.1721083526365365 0.5621745961644438 0.09612358425633553 0.22131751678737135 1.4548384457131583e-07 6.83718523075421 1.2007603910647897 ELNITAAK(ub)EIEVGGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELNITAAKEIEVGGGR 16 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 1 53963500.0 9817900.0 16229200.0 27916400.0 True False 13447842.948771289 15512140.28121244 21323121.276305314 1.0 1.153503973856994 1.5856164708001426 23.680871445418788 -6.952872367685491 0.5263674566621235 0.993002258677153 1.765612842716908 0.9994078379756236 0.006033262292565704 0.08235246134106952 0.03134470866750644 0.0067676562934287235 0.035717330746014186 1.1146220553458623e-07 6.952872367685491 0.772610584039755 ELNITAAK(ub)EIEVGGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELNITAAKEIEVGGGR 16 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 1 61605400.0 18857900.0 26727400.0 16020100.0 True False 15681179.396619378 26583414.191226445 19369828.841426656 1.0 1.695243292539426 1.2352278072657275 23.902530734230112 -10.201503470491721 3.945256274008666 0.9996729630600627 1.4652355500141194 0.5769461433896532 0.18780053584597386 18559486.70391555 7998506.183801594 50654.53993633122 0.06428911828697453 6.287768294778749e-11 10.201503470491721 0.4655625869540567 ELNITAAK(ub)EIEVGGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELNITAAKEIEVGGGR 16 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 1 247155600.0 33587800.0 42739800.0 170828000.0 True False 43480069.21451996 40361292.55869628 139739056.84329936 1.0 0.9282711202588844 3.213864636550168 25.373850901158296 -6.89965561240768 0.9634499090263727 0.9040697085096892 3.452098121354488 0.9863935820540449 0.12375460256163327 0.11165992308210523 0.17885776196120678 0.09640013431902353 0.25038412454336156 1.259924112576475e-07 6.89965561240768 2.5480284128447988 up ELNK(ub)SINPDEAVAYGAAVQAAILSGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELNKSINPDEAVAYGAAVQAAILSGDK 27 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 24956700.0 5127400.0 5256300.0 14573000.0 True False 4964633.493596865 7355168.001242387 10755894.119371176 1.0 1.4815127865387674 2.166503153403688 22.24325578627478 -6.966122926563758 0.3382262269782265 0.9241596690918843 2.7465593561504273 0.9999344564995566 0.0038749483911010595 0.0775819381069841 0.013527606629563135 0.009722939082676876 0.05936657486368775 1.0811278959528918e-07 6.966122926563758 1.822399687058543 ELNK(ub)SINPDEAVAYGAAVQAAILSGDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELNKSINPDEAVAYGAAVQAAILSGDK 27 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 90010700.0 7337700.0 37204000.0 45469000.0 True False 11131827.35772565 30564655.52382127 36482032.22022932 1.0 2.7456997437719832 3.277272549049214 23.40818710357001 -9.776728090631275 0.3147469059156841 1.4378725491644426e-24 3.4472165344825956 0.9987515432188259 0.03437031506496059 1.1478308238560788 0.13505812667828776 1.290076717146342 0.17736984428851565 1.6721372024822727e-10 9.776728090631275 3.4472165344825956 ELNK(ub)SINPDEAVAYGAAVQAAILSGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELNKSINPDEAVAYGAAVQAAILSGDK 27 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 18057300.0 5127400.0 4381100.0 8548800.0 True False 4263660.282333997 4357498.144719739 10336314.55481478 1.0 1.0220087568361271 2.4242819245337515 22.023661061709056 -6.910312225056065 0.8936065254756616 0.9570104069061498 2.6067172802455887 0.9910388447927664 0.06307288440486969 0.10421189940354195 0.13765024468630357 0.051718459339511226 0.14307696147283822 1.229384617989652e-07 6.910312225056065 1.6497068733394389 up ELNK(ub)SINPDEAVAYGAAVQAAILSGDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELNKSINPDEAVAYGAAVQAAILSGDK 27 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 52133700.0 7337700.0 19217000.0 25579000.0 True False 9498797.297690928 18147557.056899354 20923884.46270374 1.0 1.9105110350455485 2.2027930281015835 23.17931342566246 -10.461218071038946 0.24575339080220357 2.5093937199348155e-12 2.3611145113734016 0.9991691164603382 0.014764285490999517 2.0915672926513365 0.12133720235090836 1.4349109582449744 0.13567090804475931 3.4576571588526614e-11 10.461218071038946 2.361114511370892 ELNLSFCEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELNLSFCEIK 10 0 P46060;H0Y4Q3 P46060 RANGAP1 Ran GTPase-activating protein 1 0 12078200.0 4807900.0 3395200.0 3875100.0 False True 6303203.459769824 2888649.394385943 3474141.824583965 1.0 0.4582827466736143 0.5511708207989262 22.587653801255637 -10.490966653493533 6.538215666210057 1.0002326349929014 0.5047267837362702 0.9742970545075335 0.03792139746613918 0.00012865271967663576 1.001627991179123e-05 0.036734028678011114 0.012239078404272435 3.2287420252386966e-11 10.490966653493533 -0.49550585125663116 ELNLSFCEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELNLSFCEIK 10 0 P46060;H0Y4Q3 P46060 RANGAP1 Ran GTPase-activating protein 1 0 11262500.0 4807900.0 3499600.0 2955000.0 False True 6585510.558612073 3344976.1003703782 2257089.8601353406 1.0 0.5079296541398831 0.3427357438799753 22.65086386277853 -13.999999999999998 0.1524586886275573 3.3888260991793446 0.1660287002672351 0.9995582412313769 0.00586758986636809 11.96780915232335 0.12309188151961867 8.463839707727615 0.1596662389459816 1.0000000000000041e-14 13.999999999999998 -3.2227973989121095 ELNLVLSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELNLVLSVR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 10444100.0 4787800.0 2673200.0 2983100.0 False True 4635813.90970922 3740622.700553836 2201736.6189182843 1.0 0.8068966471495974 0.4749406817877182 22.144391224338086 -6.962893553219504 0.3925316662360786 1.019821175919125 0.25004015385595374 0.9998629196389706 0.0025387688922245007 0.0786832411482428 0.017427299783107593 0.004280436598493011 0.027893995649932602 1.0891970258272202e-07 6.962893553219504 -0.7697810220631711 down ELNLVLSVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELNLVLSVR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 220094000.0 56207000.0 80176000.0 83711000.0 False True 85270128.2821164 65867966.382052846 67165484.15816528 1.0 0.7724623817162388 0.7876789388183882 26.34553709125334 -10.112540119643361 4.879151004316877 1.0000102856653252 0.7800706602660333 0.9964225658131783 0.006212133428122349 6.95088137593211e-07 1.264229728779344e-07 0.0060151535533132985 0.0020049574419975327 7.717202216324559e-11 10.112540119643361 -0.2199396253992919 ELNLVLSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELNLVLSVR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 13116000.0 4787800.0 2152700.0 6175500.0 False True 3981267.83550312 2141102.977822505 7466768.497714141 1.0 0.5377942570778913 1.8754750512208511 21.924796499772363 -6.813406195184915 1.4001761969913042 0.749095671894977 1.9007429767848107 0.8685293741985453 0.20113714230814791 0.20219494086558276 0.7806019355839292 0.11293293994624573 0.2608564622122153 1.5367166784074916e-07 6.813406195184915 1.1516473048898337 ELNLVLSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELNLVLSVR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 156855000.0 56207000.0 55901000.0 44747000.0 False True 72761069.50560993 52790060.20907166 36603505.142992474 1.0 0.7255261717256851 0.5030644188121824 26.11666341334579 -7.047718172472911 0.1572021252278808 1.2391510345374948 4.769916719714653e-10 0.9999982513797208 0.0002686974158812137 0.07244076631079481 0.00494796837834193 0.01110603545432583 0.02687011518662917 8.959459848401329e-08 7.047718172472911 -1.239151034060503 ELNNLLK(ub)FNPDFAEAHYLSYLNNLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELNNLLKFNPDFAEAHYLSYLNNLR 25 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5GY68;Q9UJX4-2 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 74239000.0 10839000.0 15897000.0 47503000.0 True False 16443555.437042706 13060056.146172091 38114011.22869546 1.0 0.7942355408582416 2.3178692330026944 23.971018937489482 -6.8728299331972424 1.119070722144596 0.8813875218173444 2.4120130222687566 0.9674242281033678 0.12182842755357029 0.13416767076416186 0.3123189537651814 0.08433764763364125 0.200705741336846 1.3402013985505626e-07 6.8728299331972424 1.5306255004514122 up ELNNLLK(ub)FNPDFAEAHYLSYLNNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELNNLLKFNPDFAEAHYLSYLNNLR 25 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5GY68;Q9UJX4-2 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 46444000.0 10839000.0 11376000.0 24229000.0 True False 14031299.168632124 10742915.599692302 19819570.61053398 1.0 0.7656394087661379 1.4125256950434006 23.742145259581932 -6.8086973744691965 1.4200802934875731 0.8720787792098575 1.423500458801994 0.8563825679822745 0.10133938465518483 0.20858080362359466 0.8292803003591636 0.056117141025056314 0.12988407320919693 1.553469122858345e-07 6.8086973744691965 0.5514216795921364 ELNPYWKDGGTGLPPEDCSVSSITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELNPYWKDGGTGLPPEDCSVSSITK 25 1 H0YE03;H7C3G7;Q2TBE0-3;Q2TBE0-2;Q2TBE0 H0YE03 CWF19L2 CWF19-like protein 2 0 6788600.0 2067500.0 1317300.0 3403800.0 False True 2831910.622086662 1259097.330271431 2599892.543461477 1.0 0.44461054683416495 0.9180701266432537 21.433344302574486 -10.199105006116472 7.854601635175863 1.0000001631608524 0.6813403367387119 0.37655328800154386 0.1932890640607994 5.523352905158715e-07 5.609787509775718e-08 0.1871514291332899 0.06238377717595787 6.322589618328366e-11 10.199105006116472 -0.3186598264221405 ELNSNHDGADETSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELNSNHDGADETSEK 15 0 Q01105-2 Q01105-2 SET Protein SET 0 27248300.0 9093700.0 3678600.0 14476000.0 False True 8805025.47113971 5147484.163645575 10684301.329308795 1.0 0.5846075267490727 1.2134321887345811 23.069895746808687 -6.728626226186313 1.728918267571059 0.7496267851692769 1.212917977106821 0.5525965356560207 0.17464028390727185 0.3388133473914108 1.9835987352643596 0.08008008780480697 0.1989715992557104 1.8679866744944673e-07 6.728626226186313 0.4632911919375441 ELNSNHDGADETSEK(ub)EQQEAIEHIDEVQNEIDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELNSNHDGADETSEKEQQEAIEHIDEVQNEIDR 33 1 Q01105-2 Q01105-2 SET Protein SET 1 54246600.0 20287800.0 10875000.0 23083800.0 True False 19643774.89398024 15217444.212375792 17037460.280844048 1.0 0.7746700567740227 0.8673210914295864 24.227568859521867 -10.083442145120635 5.463804239964093 1.000001757806389 0.8209955741249023 0.8326913690055171 0.03782462650814418 8.099203862494025e-07 1.3584157417025616e-07 0.03662389675838751 0.012207845711836045 8.251974074755592e-11 10.083442145120635 -0.17900618368148657 ELNSNHDGADETSEK(ub)EQQEAIEHIDEVQNEIDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELNSNHDGADETSEKEQQEAIEHIDEVQNEIDR 33 1 Q01105-2 Q01105-2 SET Protein SET 1 41364500.0 20287800.0 16515400.0 4561300.0 True False 16870204.601929925 16426428.262149781 5515046.740931662 1.0 0.9736946675958289 0.32691048336786316 24.007974134956143 -6.915462032199458 0.8577139041021828 1.0167353027483859 0.23277246262227108 0.9928245138303017 0.026368193987549915 0.10091605867197811 0.11999685703074994 0.022188859355501918 0.06383686749952822 1.2148928267303597e-07 6.915462032199458 -0.7839628401261147 down ELNSNHDGADETSEK(ub)EQQEAIEHIDEVQNEIDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELNSNHDGADETSEKEQQEAIEHIDEVQNEIDR 33 1 Q01105-2 Q01105-2 SET Protein SET 1 46401000.0 18061000.0 17238000.0 11102000.0 True False 23380320.53553512 16278690.146580176 9081549.916139677 1.0 0.6962560723595997 0.3884270920211241 24.478791373031363 -7.077563250900201 0.24607493750940834 1.1082733726153207 2.748907477220851e-11 0.999984696875121 0.0009766935422021528 0.07434906316566275 0.009042829794623411 0.007976414076373327 0.030008505331337976 8.36443766729143e-08 7.077563250900201 -1.1082733725878315 down ELNYFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELNYFAK 7 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 30091100.0 1087100.0 16514000.0 12490000.0 False True 1425198.6274913757 14050175.571067836 11197654.612539977 1.0 9.858398190993809 7.856908080419645 20.442731568550503 -9.37508206463937 8.781991370587182 1.0000106099744508 8.857653135707464 0.9535968705551615 0.8171049160478853 0.0 0.0 0.7911584329778321 0.2637194776592773 4.216168268416089e-10 9.37508206463937 7.857642525733013 ELNYFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELNYFAK 7 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 28336100.0 11233000.0 3532100.0 13571000.0 False True 10876414.563633326 4942485.949658164 10016347.978726828 1.0 0.4544223577302757 0.9209237033146713 23.374699711262377 -10.199583238790856 7.864658078761489 1.0000001583453593 0.6876730305224753 0.374083368767561 0.1904483768339213 5.288363965524676e-07 5.3805211432000126e-08 0.18440094137075508 0.06146694931583429 6.31563119520739e-11 10.199583238790856 -0.31232712782288397 ELNYFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELNYFAK 7 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 24545100.0 1087100.0 11641000.0 11817000.0 False True 1489030.2477728727 11126662.128360853 9026067.978754427 1.0 7.472421829578605 6.061708949334391 20.505941630073394 -10.461234638178428 6.67359109964155 0.9985362896276399 6.767065389456498 0.9570499777802479 0.5759211216950526 0.012539170391776006 0.0010123011575265922 0.5574908872433804 0.18587774275450275 3.457525261261901e-11 10.461234638178428 5.768529099828858 ELNYFAK(ub)ALESPERPFLAILGGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELNYFAKALESPERPFLAILGGAK 24 2 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 26298400.0 5529100.0 9407300.0 11362000.0 True False 8388048.931354634 7728493.815429625 9116295.719858488 1.0 0.9213696627997026 1.086819568467425 22.999903846688195 -6.777464199529965 1.5456290912315283 0.9553302652951646 1.0880299483262827 0.758333524696924 0.033218219995262 0.25454680924180284 1.2009191555020884 0.016929951854275073 0.04003510732813775 1.6693054084415955e-07 6.777464199529965 0.13269968303111812 ELNYFAK(ub)ALESPERPFLAILGGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELNYFAKALESPERPFLAILGGAK 24 2 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 21883900.0 5529100.0 5190800.0 11164000.0 True False 7157528.944855053 4901927.416920085 9132266.552313393 1.0 0.6848630937697667 1.2758965590880094 22.771030168780644 -6.7618527217074265 1.6053942635976128 0.8173715075226797 1.278262694646379 0.6985038025269596 0.13258554972046607 0.2798267153516235 1.4217906678805816 0.06514786712541876 0.15628189735169423 1.7304030754026328e-07 6.7618527217074265 0.46089118712369936 ELPSFLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELPSFLGK 8 0 P26447 P26447 S100A4 Protein S100-A4 0 37778400.0 3175400.0 17904000.0 16699000.0 False True 4162980.1506173415 15232792.989245381 14971147.668118916 1.0 3.6591077636981915 3.5962572787907234 21.989185248947106 -10.107781879198164 4.483109296880964 0.99973944564655 3.627682521355095 0.9995711094516193 0.025658603432864822 1903766.1570089075 1430778.2203847065 4392.465616607775 0.008783622405820072 7.802218721002321e-11 10.107781879198164 2.6279430757085454 ELPSFLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELPSFLGK 8 0 P26447 P26447 S100A4 Protein S100-A4 0 35613200.0 14888000.0 4013200.0 16712000.0 False True 14415388.589279193 5615691.68856153 12334625.85074666 1.0 0.3895622829576687 0.8556568402131033 23.781106391663144 -9.912262844499784 6.599927531832501 1.0000000249922016 0.6226095615854141 0.46641704105554016 0.19028230619407918 6.993471088913122e-08 1.164724126842202e-08 0.1842400617234218 0.06141335024729533 1.2238752590507943e-10 9.912262844499784 -0.3773904634067875 ELPSFLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELPSFLGK 8 0 P26447 P26447 S100A4 Protein S100-A4 0 37899400.0 3175400.0 17008000.0 17716000.0 False True 4349431.191958401 16256530.322065227 13531845.672472974 1.0 3.7376221405966104 3.1111759389346823 22.052395310469997 -9.362964891237153 9.936169260453156 0.9999999999999991 3.424399039765654 0.9523129656201443 0.25574559089609084 0.0 0.0 0.24762460360162108 0.08254153453387368 4.335459252197411e-10 9.362964891237153 2.424399039765655 ELPSFLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELPSFLGK 8 0 P26447 P26447 S100A4 Protein S100-A4 0 18241600.0 14888000.0 1595600.0 1758000.0 False True 12380031.650229853 1587004.186098198 2125589.6719263955 1.0 0.1281906404551666 0.17169501112599586 23.56151166709742 -10.362093345957568 5.476293751613839 1.0002729505120376 0.14994282583141857 0.9980394472876655 0.017760584954112542 5.9205749448762306e-05 6.8965990278028595e-06 0.017201927668733297 0.0057322041455091545 4.344168418790201e-11 10.362093345957568 -0.850330124680619 ELPSFLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELPSFLGK 8 0 P26447 P26447 S100A4 Protein S100-A4 0 7231100.0 2056800.0 2099400.0 3074900.0 False True 2662568.1455893116 1982566.5444790828 2515299.75113834 1.0 0.7446068742928934 0.9446893426202332 21.344387019374626 -9.88079496268827 5.532540548461047 1.0000000998318626 0.8446481087121953 0.445618084371899 0.08168332564891916 1.0054845410641873e-07 2.034316292491627e-08 0.07908959006143965 0.026363179991396684 1.3158459172922154e-10 9.88079496268827 -0.15535199111966724 ELPSFLGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELPSFLGKR 9 1 P26447 P26447 S100A4 Protein S100-A4 1 9707300.0 4585400.0 2526100.0 2595800.0 True False 6011503.80507676 2149215.7266606786 2327211.516671843 1.0 0.3575171531698358 0.38712634843655847 22.519294502148306 -10.719478124069223 6.810242927186497 1.0077146274445083 0.3723217508031971 0.9983338419141606 0.012087903349650238 0.0014125987365945438 5.8186528933064545e-05 0.0116768321849176 0.0039013540303133535 1.907751817303154e-11 10.719478124069223 -0.6353928766413113 ELPSFLGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELPSFLGKR 9 1 P26447 P26447 S100A4 Protein S100-A4 1 21271600.0 8977200.0 8053400.0 4241000.0 True False 8692223.699870845 11269164.617926184 3130154.8727271706 1.0 1.2964650942075535 0.36010979247734737 23.051293872989877 -6.821562220852452 1.3650740332452762 1.1595453114765686 0.3389701752258331 0.8879462354949431 0.1307985956664946 0.19145772807874467 0.7005948035022367 0.07528753317404553 0.17345989695474626 1.5081265275729682e-07 6.821562220852452 -0.8205751362507354 down ELPSFLGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELPSFLGKR 9 1 P26447 P26447 S100A4 Protein S100-A4 1 8843500.0 4585400.0 1835500.0 2422600.0 True False 6280746.295775662 1754401.540813188 1850431.775013156 1.0 0.2793301079512116 0.2946197295467466 22.582504563671197 -10.039411149838324 6.162445741008473 1.0000008580805764 0.2869749188688159 0.9996552567672805 0.006241961878295272 7.359000932948661e-08 1.1464833668379213e-08 0.006043760939429505 0.0020145845335133652 9.132482531290935e-11 10.039411149838324 -0.7130259392117605 ELPSFLGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELPSFLGKR 9 1 P26447 P26447 S100A4 Protein S100-A4 1 21076600.0 8977200.0 9845900.0 2253500.0 True False 7464939.557391416 9792858.18244187 2724696.43099325 1.0 1.3118469489475588 0.36499912826425895 22.831699148424153 -6.817948859730895 1.3806491739931528 1.168436760740338 0.34520911250435443 0.8796332105124436 0.13668774375513765 0.1961484395451363 0.7352227861745615 0.07780891055080132 0.17944916659715138 1.5207265920776476e-07 6.817948859730895 -0.8232276482359837 down ELPSFLGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELPSFLGKR 9 1 P26447 P26447 S100A4 Protein S100-A4 1 10660400.0 1830400.0 4194500.0 4635500.0 True False 2369488.8825781215 3961072.3877381715 3791886.564246578 1.0 1.6716990811234902 1.6002972590953106 21.17614446131936 -10.279292085218833 4.874075593531373 0.9998047140455787 1.635998170109985 0.9906355548994878 0.029149671781027977 6.187709793175109e-05 9.149442474141755e-06 0.028232576329965106 0.00940801611265682 5.256636118536519e-11 10.279292085218833 0.6361934560644064 ELPTVTTNVQNSQDK(ub)SIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELPTVTTNVQNSQDKSIEK 19 1 F5H1Y0;H0YGT5;Q96B01-3;Q96B01-2;Q96B01 F5H1Y0 RAD51AP1 RAD51-associated protein 1 1 10137900.0 2974100.0 2525500.0 4638300.0 True False 2879688.82344003 3533945.320308518 3423390.0839826604 1.0 1.2271969427887433 1.1888055598636291 21.457481493097777 -10.102106994697419 4.528662007997261 0.9999821428559031 1.2080012513337268 0.9750862012481499 0.015673216473383666 2.826042762962269e-06 5.603525869803e-07 0.015176828908070535 0.005058508861634892 7.904838569310702e-11 10.102106994697419 0.20801910847782368 ELPTVTTNVQNSQDK(ub)SIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELPTVTTNVQNSQDKSIEK 19 1 F5H1Y0;H0YGT5;Q96B01-3;Q96B01-2;Q96B01 F5H1Y0 RAD51AP1 RAD51-associated protein 1 1 7781100.0 2974100.0 3543400.0 1263600.0 True False 2473095.9249696764 3524311.0008901656 1527812.9177737145 1.0 1.425060372833447 0.6177734160442837 21.237886768532054 -6.763677155707628 1.5989891696457565 1.2457710887415654 0.6143125254535886 0.7056660553529104 0.17888592248499388 0.2767807612601992 1.3955628171883863 0.08824308422508005 0.2112686981128068 1.7231490474207756e-07 6.763677155707628 -0.6314585632879768 ELPVLWHQCLLTLVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELPVLWHQCLLTLVQR 16 0 Q13895 Q13895 BYSL Bystin 0 4781800.0 362200.0 1067400.0 3352200.0 False True 496115.12808696035 1020238.738580221 2560479.4007261232 1.0 2.05645561044329 5.161058907031183 18.920315424578657 -6.951913904892317 0.5374217972346956 0.9535009021342435 6.406752431612126 0.999343045580724 0.04526477677053296 0.08272620337215318 0.03285132803184797 0.04996428973550818 0.2570020100669968 1.1170846781632014e-07 6.951913904892317 5.453251529477882 ELQAAGK(ub)SPEDLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELQAAGKSPEDLER 14 1 P06744;A0A2U3TZU2;P06744-2 P06744 GPI Glucose-6-phosphate isomerase 1 5992700.0 1291400.0 1584900.0 3116400.0 True False 1250405.2138766206 2217758.8351443117 2300121.350004002 1.0 1.7736321078417554 1.839500767013723 20.253964268463978 -11.174736854876446 0.429411198245028 4.644321354464731e-19 1.8417099650203637 0.9996616053736681 0.007011790337622324 3.177037372698315 0.21110214130594318 3.074758460973302 0.0155835365931122 6.687489992409514e-12 11.174736854876446 1.8417099650203637 ELQAAGK(ub)SPEDLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELQAAGKSPEDLER 14 1 P06744;A0A2U3TZU2;P06744-2 P06744 GPI Glucose-6-phosphate isomerase 1 19040400.0 1995700.0 3185200.0 13859500.0 True False 2583472.9911282565 3007940.819984171 11337213.210478982 1.0 1.1643012449960009 4.388361422554599 21.30088037053653 -6.917475432807515 0.8432457506272165 0.9221869430210146 4.87922268498459 0.9934502907968675 0.12625166510890765 0.09967995395982522 0.11348187304059372 0.10734891345569644 0.31419085638307725 1.2092735872586315e-07 6.917475432807515 3.9570357419635758 up ELQDSTQMNEK(ub)ELTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELQDSTQMNEKELTK 15 1 Q5T2B5;A0A0A0MTN0;Q13617;Q13617-2 Q5T2B5 CUL2 Cullin-2 1 6189700.0 2318900.0 2486300.0 1384500.0 True False 3040100.356259543 2115353.7315214924 1241245.2210617792 1.0 0.6958170730008947 0.4082908705648697 21.535687518351004 -7.105543412456895 0.22394419897503418 1.13415876239651 6.683414372029206e-11 0.9999886404488828 0.0008142535556764264 0.07710864784114461 0.00849619323363857 0.00940306112923401 0.030843974954626957 7.842537202746694e-08 7.105543412456895 -1.1341587623296758 down ELQDSTQMNEK(ub)ELTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELQDSTQMNEKELTK 15 1 Q5T2B5;A0A0A0MTN0;Q13617;Q13617-2 Q5T2B5 CUL2 Cullin-2 1 5839600.0 1827400.0 1445400.0 2566800.0 True False 1769390.1872681878 2022555.7576614243 1894478.0776505794 1.0 1.1430806908588693 1.0706954810094875 20.754820796642743 -10.797531859105401 6.9724277612966645 0.9958577643604436 1.106888085934153 0.7440722129014834 0.029551138175878094 0.0019679892568277312 5.714716027933882e-05 0.029592909917661513 0.00953758883472084 1.59392594872351e-11 10.797531859105401 0.1110303215737094 ELQDSTQMNEK(ub)ELTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELQDSTQMNEKELTK 15 1 Q5T2B5;A0A0A0MTN0;Q13617;Q13617-2 Q5T2B5 CUL2 Cullin-2 1 5989200.0 1827400.0 2593000.0 1568800.0 True False 1519564.0675463472 2579030.9943298 1896828.8266883546 1.0 1.6972176753917214 1.248271703180755 20.53522607207702 -10.22821208827152 3.945193862847474 0.9995991446247261 1.4727446889602065 0.5965204934396835 0.1832814265688378 20364571.64706123 10559533.07056465 70869.34647679314 0.06274210679660061 5.912728148152823e-11 10.22821208827152 0.4731455443354804 ELQDSTQMNEK(ub)ELTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELQDSTQMNEKELTK 15 1 Q5T2B5;A0A0A0MTN0;Q13617;Q13617-2 Q5T2B5 CUL2 Cullin-2 1 13805900.0 3857700.0 7800300.0 2147900.0 True False 4993868.696635495 7366206.447985231 1757004.2393151165 1.0 1.4750500855074633 0.3518322859587514 22.25172645843108 -6.791805242386602 1.4892030672055405 1.2648795736796494 0.33929672483198486 0.8071088077212312 0.20218885894132183 0.23266128705579017 1.019298436389875 0.10685842935055975 0.2498469846176389 1.6150826717783894e-07 6.791805242386602 -0.9255828488476645 down ELQELNELFKPVVAAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELQELNELFKPVVAAQK 17 1 Q8WU90;F8WB26 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 0 4247530.0 411930.0 2570000.0 1265600.0 False True 540044.2191357942 2186566.017781535 1134647.8524924424 1.0 4.048864778666806 2.101027679378112 19.042718015261208 -9.868595433073708 6.413232652972625 0.9999998853462747 3.074946229022704 0.6020737830333001 0.7952011658875784 1.3090789937823165e-06 2.3256757779985567e-07 0.7699502639817558 0.2566500726971466 1.3533326729207506e-10 9.868595433073708 2.0749463436764293 ELQELNELFKPVVAAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELQELNELFKPVVAAQK 17 1 Q8WU90;F8WB26 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 0 3814730.0 411930.0 1619900.0 1782900.0 False True 564231.652989678 1548327.461707046 1361815.7399781058 1.0 2.744134352447205 2.4135755815227524 19.1059280767841 -10.241944477352709 6.034114394340335 0.999957912948979 2.5788549669849843 0.9681707704865222 0.13495005312776254 7.640965031028779e-05 9.599443282819106e-06 0.13066826508098764 0.04355494236113309 5.728692651307634e-11 10.241944477352709 1.5788970540360054 ELQELVQYPVEHPDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELQELVQYPVEHPDK 15 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 14071700.0 4146800.0 1231900.0 8693000.0 False True 4015162.103843558 1723804.0942736322 6416042.515590026 1.0 0.42932366108543957 1.5979535445027733 21.93702680406308 -6.773910418256397 1.5593478789585833 0.6743105409640785 1.6055410460130313 0.7453226051627704 0.24078863945862644 0.26016230773697646 1.2489379004971117 0.12167283377933791 0.28862185728174083 1.683021181353761e-07 6.773910418256397 0.9312305050489528 ELQELVQYPVEHPDKFLK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELQELVQYPVEHPDKFLK 18 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 93554300.0 18507000.0 49289000.0 25758300.0 True False 24262856.22204292 41935273.327017196 23093078.20706075 1.0 1.7283733185921781 0.9517872914764496 24.53224605864464 -6.66062940622463 1.9704834567003016 1.4686170771488924 0.9550174476271034 0.2382012816580208 0.3100817317200369 0.4830569139260096 3.6062067296630222 0.12710130973637035 0.3438003972450451 2.1845932819292812e-07 6.66062940622463 -0.5135996295217891 ELQELVQYPVEHPDKFLK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELQELVQYPVEHPDKFLK 18 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 114432000.0 53798000.0 30431000.0 30203000.0 True False 52090211.93753634 42582256.99556859 22291928.229422055 1.0 0.8174713715242865 0.42794850318814764 25.634508971152535 -6.958756432535063 0.4526185454124138 1.0122305013838202 0.2176797908899519 0.9997212617756185 0.003983212807493735 0.08014836740442244 0.02279546427954076 0.005227099788704251 0.0322078809075172 1.0996223730385515e-07 6.958756432535063 -0.7945507104938683 down ELQELVQYPVEHPDKFLK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELQELVQYPVEHPDKFLK 18 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 353440000.0 131255000.0 169403000.0 52782000.0 True False 199123431.02583644 139171711.09831986 42349614.56482754 1.0 0.6989218214116761 0.21268021722331934 27.56908775331571 -7.228724447488001 0.44372735571250327 1.019775803092163 4.942481575837869e-16 0.9994052128105406 0.007910852366420213 0.09192854846241261 0.03256284617380865 0.010437047178278886 0.0481861838461089 5.9057567161003436e-08 7.228724447488001 -1.0197758030921626 down ELQELVQYPVEHPDKFLK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELQELVQYPVEHPDKFLK 18 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 85907000.0 18507000.0 39120000.0 28280000.0 True False 25349538.03286958 37391549.04745953 21600846.44488237 1.0 1.4750386771930764 0.8521199249025188 24.59545612016753 -6.702910855760803 1.8208581837653732 1.2941449260270002 0.8538924678742909 0.4312089744450519 0.2004161519010155 0.38951142234212954 2.5127886091207197 0.08774981535899559 0.22483114736670098 1.9819338001407148e-07 6.702910855760803 -0.4402524581527093 ELQELVQYPVEHPDKFLK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELQELVQYPVEHPDKFLK 18 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 104148000.0 53798000.0 38558000.0 11792000.0 True False 44735420.655498706 38350280.4008362 14257652.679952234 1.0 0.8572688004024017 0.31871059824715736 25.41491424658681 -6.946217051117074 0.5989416669455251 1.0060804605168068 0.1423802074847158 0.9988699428082068 0.00986188392240476 0.08504138734124977 0.04253060475913964 0.010132250222004162 0.04524347347901713 1.1318345550931673e-07 6.946217051117074 -0.863700253032091 down ELQELVQYPVEHPDKFLK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELQELVQYPVEHPDKFLK 18 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 355220000.0 131255000.0 167060000.0 56905000.0 True False 169912184.9228536 157762964.1424576 46548873.894607134 1.0 0.9284970599023714 0.27395842102637924 27.34021407540816 -6.927680828141124 0.7656033798107529 1.0108572800814692 0.14719709961792238 0.9960621436644949 0.020501977284841644 0.0938605123268156 0.08371599724924203 0.018426647596427054 0.05999770780277234 1.1811883961517078e-07 6.927680828141124 -0.8636601804635469 down ELQELVQYPVEHPDKFLKFGMTPSK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELQELVQYPVEHPDKFLKFGMTPSK 25 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 44104000.0 9967000.0 17624000.0 16513000.0 True False 15120667.68530352 14478859.503059499 13249198.312094983 1.0 0.9575542432648113 0.8762310360786841 23.850018510450973 -6.960876115043056 0.4229075534332031 1.0034840875149225 0.8272188096856249 0.9998013071388636 0.000723836165445645 0.07938966345490714 0.01998603660660432 0.0010540807446926157 0.006764217986850024 1.0942684680242905e-07 6.960876115043056 -0.17626527782929757 ELQELVQYPVEHPDKFLKFGMTPSK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELQELVQYPVEHPDKFLKFGMTPSK 25 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 41898000.0 9967000.0 18799000.0 13132000.0 True False 12902477.978942387 17752819.124350913 10742110.745698621 1.0 1.375923226013218 0.8325618352715182 23.621144832543422 -6.720617861360619 1.757389631425446 1.2285589691818688 0.833396258947612 0.5153160183767911 0.1581778021674068 0.35410916983638085 2.1377177200066977 0.07146250778724075 0.17924721478698605 1.902751787661998e-07 6.720617861360619 -0.39516271023425675 ELQEMDKDDESLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELQEMDKDDESLIK 14 1 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 29054100.0 9108200.0 2118100.0 17827800.0 False True 8819065.17657662 2963868.375745581 13158164.357464153 1.0 0.33607511866649953 1.492013506421537 23.072194307125798 -6.750953927406123 1.6464529243027841 0.6100539379013126 1.4944617180510524 0.65302735998538 0.2789984149830715 0.29837497137320096 1.5916988800203151 0.13384945790923292 0.32460782013951484 1.7743777076597668e-07 6.750953927406123 0.8844077801497399 ELQEMDKDDESLIK(ub)YK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELQEMDKDDESLIKYK 16 2 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 31307100.0 7704500.0 8532600.0 15070000.0 True False 11688289.774397615 7009890.864491922 12091407.894584348 1.0 0.5997362317151479 1.0344890593891447 23.478560514996744 -6.664634838214819 1.9565735801855344 0.7433604988752921 1.032696815110634 0.2556944890820081 0.17023269728563023 0.47338207089724194 3.4884002124186924 0.07017885703975722 0.1888095103388075 2.1645377369496553e-07 6.664634838214819 0.28933631623534184 ELQEMDKDDESLIK(ub)YK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELQEMDKDDESLIKYK 16 2 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 39631500.0 7704500.0 10803000.0 21124000.0 True False 9973627.128399886 10201803.553399783 17279648.75054356 1.0 1.022877978298403 1.7325340648979939 23.249686837089193 -6.913763911243871 0.8697142831208966 0.9805556981484518 1.8320294082391977 0.9922659795933123 0.029905618766840315 0.10198152143562325 0.12565722101293386 0.024949179552548096 0.07080633085351146 1.219652439434351e-07 6.913763911243871 0.8514737100907459 ELQK(ub)ANQEQYAEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELQKANQEQYAEGK 14 1 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;H0YNE0 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 1 35290600.0 14224000.0 20065000.0 1001600.0 True False 18647801.745411955 17071380.212757397 897964.0400256234 1.0 0.915463412032337 0.048153881743544145 24.15250223582273 -7.051460255154648 0.9104786736173724 1.0052393133359008 5.614837376435028e-16 0.9933744340912415 0.03501445169223888 0.0805979543063669 0.12012676864302836 0.030104366057569353 0.06392183275338466 8.882592624352639e-08 7.051460255154648 -1.0052393133359 down ELQK(ub)ANQEQYAEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELQKANQEQYAEGK 14 1 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;H0YNE0 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 1 53181300.0 25819000.0 24821000.0 2541300.0 True False 24999389.977606043 34732154.73980504 1875657.2926341821 1.0 1.3893200902468987 0.07502812245876234 24.575389555618095 -6.827318809057254 1.3396620611381713 1.2084366552056474 0.041500749597719815 0.9004735381037285 0.17389516479939174 0.18411496594803334 0.6471424126218598 0.1019429764372864 0.23466339624231838 1.4882681613057228e-07 6.827318809057254 -1.1669359056079276 down ELQK(ub)ANQEQYAEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELQKANQEQYAEGK 14 1 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;H0YNE0 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 1 53761600.0 44855000.0 6549000.0 2357600.0 True False 68048314.33975004 5380279.782429455 1891619.326627213 1.0 0.0790655850131264 0.0277981805277759 26.020056088632888 -13.308258172399274 0.41832976748820627 9.998280558511516 0.025954693222043985 0.9998493455668075 0.0054829407267063205 16.29479196556214 0.2147157368465088 131.10499073328256 0.012496209914816921 4.9174712285431216e-14 13.308258172399274 -9.972325865289472 ELQK(ub)ANQEQYAEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELQKANQEQYAEGK 14 1 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;H0YNE0 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 1 31092260.0 14224000.0 15983000.0 885260.0 True False 19482997.189146675 15276818.21128696 676179.8205020007 1.0 0.7841102712778281 0.034706149877118384 24.215712297345622 -7.2446456204085425 0.7778689992448723 0.9923470476721008 7.237327728088662e-19 0.9923935909046337 0.03607696084907155 0.09533857803437248 0.10894483374892534 0.03139685435792168 0.06429362147711722 5.6931729810519395e-08 7.2446456204085425 -0.9923470476721008 down ELQK(ub)ANQEQYAEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELQKANQEQYAEGK 14 1 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;H0YNE0 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 1 65139720.0 25819000.0 38715000.0 605720.0 True False 21469642.47563702 38506434.61067414 732373.2514671541 1.0 1.7935293824463945 0.03411203760371068 24.35579483105237 -6.78407194027266 1.5198712044013412 1.4469290302722824 0.018310933206853505 0.7816063993026624 0.3362069846516019 0.2442806097852003 1.114759205990444 0.17418081058374466 0.40964061978513516 1.6440993579011572e-07 6.78407194027266 -1.428618097065429 ELQK(ub)LNQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELQKLNQEK 9 1 Q9H8H0 Q9H8H0 NOL11 Nucleolar protein 11 1 6911270.0 2789900.0 3286600.0 834770.0 True False 3657585.9174300344 2796252.091066458 748396.008079263 1.0 0.7645075615971356 0.20461474452666198 21.80246032328312 -7.0732072985750065 0.5225508013249398 1.0083882266662327 3.5451598411275567e-14 0.999428445032872 0.00797534046956826 0.0748651440135594 0.03121900368424632 0.00907671478588224 0.04206341670677704 8.448754707344413e-08 7.0732072985750065 -1.0083882266661972 down ELQK(ub)LNQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELQKLNQEK 9 1 Q9H8H0 Q9H8H0 NOL11 Nucleolar protein 11 1 7771000.0 2828400.0 3605500.0 1337100.0 True False 2738613.990187883 5045194.952434111 986873.3978598209 1.0 1.8422439126179975 0.36035505602310763 21.38501450068795 -6.752521640673029 1.6404377727149626 1.4937398128137362 0.3568199553286209 0.6597832217055325 0.3539701227755802 0.29566576352771096 1.566163109520157 0.17039874525154214 0.41260497995308504 1.767984117790454e-07 6.752521640673029 -1.1369198574851154 ELQK(ub)LNQEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELQKLNQEK 9 1 Q9H8H0 Q9H8H0 NOL11 Nucleolar protein 11 1 10212300.0 3325400.0 3955600.0 2931300.0 True False 5044874.919304533 3249692.2747561377 2351927.270165568 1.0 0.6441571548822717 0.46620130484618555 22.26638706947125 -13.999999999999996 0.08995249702694562 2.8224569401609663 0.020378671928239046 0.9998426336931493 0.0027838764544749813 12.164148247418337 0.08713123665103828 4.239788630267983 0.40057813254512564 1.0000000000000082e-14 13.999999999999996 -2.8020782682327274 ELQK(ub)LNQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELQKLNQEK 9 1 Q9H8H0 Q9H8H0 NOL11 Nucleolar protein 11 1 5774550.0 2789900.0 2263200.0 721450.0 True False 3821401.4242126197 2163204.3405984268 551058.368729151 1.0 0.5660761852686398 0.14420321435942673 21.865670384806013 -7.769891249606991 0.40593091426895916 1.0467006097515306 5.325692069116991e-26 0.9979531221169757 0.01580721336912326 0.11507020113865934 0.07112415470486272 0.03205475559591254 0.07796291085438925 1.698668957864935e-08 7.769891249606991 -1.0467006097515306 down ELQK(ub)LNQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELQKLNQEK 9 1 Q9H8H0 Q9H8H0 NOL11 Nucleolar protein 11 1 8401980.0 2828400.0 4904900.0 668680.0 True False 2351939.9193652645 4878476.330153581 808497.8963730041 1.0 2.0742350984331996 0.3437578867198272 21.165419776122228 -6.738825766942613 1.69111140790044 1.6400434027641022 0.3430262429660013 0.5995908474717089 0.451361894799024 0.3199543752750499 1.7962211430531576 0.21119057520715642 0.518888986174549 1.82462757134271e-07 6.738825766942613 -1.2970171597981008 ELQK(ub)LNQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELQKLNQEK 9 1 Q9H8H0 Q9H8H0 NOL11 Nucleolar protein 11 1 10442400.0 3325400.0 5182100.0 1934900.0 True False 4304795.853433829 4893711.579567998 1582768.0537505557 1.0 1.1368045654625887 0.3676755199640933 22.0375133915637 -6.860923750798926 1.1809423323911379 1.074422968995588 0.32974748592301995 0.954760255787926 0.07125625330502684 0.14586035972532213 0.3859957801472732 0.047040331802342274 0.10993146303114355 1.377451287164835e-07 6.860923750798926 -0.744675483072568 down ELQK(ub)SCTFDEQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELQKSCTFDEQR 12 1 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;J3KT86;Q96GD4-2;J3QR41 Q96GD4-5 AURKB Aurora kinase B 1 5274500.0 1411400.0 1178500.0 2684600.0 True False 1366595.8795612995 1649081.1957963118 1981422.7237263338 1.0 1.2067072793499825 1.449896603202407 20.382155251369777 -6.968979586160136 0.2814913350959564 0.9473771385964795 1.7166524057502337 0.9999732931707593 0.0009502014122879963 0.07663520155633323 0.010209941545061675 0.004453754910758436 0.022280019542094933 1.0740398959740597e-07 6.968979586160136 0.7692752671537542 ELQK(ub)SCTFDEQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELQKSCTFDEQR 12 1 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;J3KT86;Q96GD4-2;J3QR41 Q96GD4-5 AURKB Aurora kinase B 1 52452300.0 4353000.0 8558300.0 39541000.0 True False 6603819.246927477 7031004.4986968925 31725704.01856405 1.0 1.0646876051261047 4.804144818670634 22.654869202123784 -6.910654381797525 0.8912753370169914 0.8866020894635199 5.294218575215084 0.9911660038213255 0.16713562009654162 0.1039865938984677 0.13643492736815876 0.1372805555155864 0.3806925005704468 1.228416434889296e-07 6.910654381797525 4.407616485751564 up ELQK(ub)SCTFDEQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELQKSCTFDEQR 12 1 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;J3KT86;Q96GD4-2;J3QR41 Q96GD4-5 AURKB Aurora kinase B 1 8783400.0 1562800.0 2253700.0 4966900.0 True False 2140609.3930820003 2154124.082010721 3793820.5165164866 1.0 1.0063134773548117 1.7723086373335168 21.02959013381216 -6.908706087612594 0.9045034674653033 0.9753015825141056 1.8686081966789343 0.9904239279351186 0.03548219918220528 0.10528001325407861 0.14345568533680908 0.028865121982195725 0.07898401318269538 1.2339396295830435e-07 6.908706087612594 0.8933066141648287 ELQK(ub)SCTFDEQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELQKSCTFDEQR 12 1 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;J3KT86;Q96GD4-2;J3QR41 Q96GD4-5 AURKB Aurora kinase B 1 8270500.0 1411400.0 1172500.0 5686600.0 True False 1173641.6356216008 1166183.5097769722 6875641.768132326 1.0 0.993645312488698 5.858382626729795 20.162560526804054 -6.906600079638057 0.9185591250042351 0.8327080107500577 6.443444157502959 0.9895744837102334 0.23400139920305582 0.10670997009138704 0.15127354185083938 0.18841614080808647 0.5086517621550181 1.2399378585792971e-07 6.906600079638057 5.610736146752901 up ELQK(ub)SCTFDEQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELQKSCTFDEQR 12 1 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;J3KT86;Q96GD4-2;J3QR41 Q96GD4-5 AURKB Aurora kinase B 1 57332000.0 4353000.0 5957000.0 47022000.0 True False 5635044.310458128 5625487.713376144 38464478.486463636 1.0 0.9983040777400369 6.825940732192127 22.425995524216233 -6.906826145646895 0.9170583799560472 0.8009576435914892 7.530138941818522 0.989668182842093 0.27919740766775414 0.10655494787476015 0.1504213614955507 0.22505453699402964 0.6084182329349033 1.2392925939672703e-07 6.906826145646895 6.729181298227033 up ELQSK(ub)EFLSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELQSKEFLSAK 11 1 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 159363000.0 57627000.0 60166000.0 41570000.0 True False 75549555.06066182 51189467.32523115 37268735.16759702 1.0 0.6775614665649459 0.49330184853732667 26.170919923060715 -10.681168651402709 0.09856975309096777 1.929816659194 3.0977655823284414e-11 0.9999104077028365 0.001982095029316061 2.7124189983773515 0.05545242835737257 0.8886619062961664 0.30081202913837446 2.0836815611395944e-11 10.681168651402709 -1.9298166591630224 ELQSK(ub)EFLSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELQSKEFLSAK 11 1 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 120660000.0 34722000.0 29318000.0 56620000.0 True False 33619769.115861915 41024830.291350245 41789523.43640952 1.0 1.2202591323565812 1.2430044743136885 25.00280648109541 -12.795168477687183 0.338569863428802 7.268150455590178e-08 1.246788492364996 0.9996702395490216 0.001990004759389789 8.793896844424115 0.18351116002829523 6.126944576684166 0.007064616157881768 1.6026235575773182e-13 12.795168477687183 1.2467884196834913 ELQSK(ub)EFLSAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELQSKEFLSAK 11 1 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 331958000.0 92900000.0 124851000.0 114207000.0 True False 140936091.89973885 102570363.58468463 91633936.39129359 1.0 0.7277792522986419 0.6501807674394822 27.070465873493262 -13.999999999999998 0.17602464594632158 2.3958072383165683 0.5859426713739726 0.9995034744428325 0.0033424160640817633 12.155882975895535 0.13295802446044228 5.798346312376646 0.0599563102266667 1.0000000000000041e-14 13.999999999999998 -1.8098645669425957 ELQSK(ub)EFLSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELQSKEFLSAK 11 1 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 119738000.0 57627000.0 31781000.0 30330000.0 True False 78933259.21111885 30376810.334287077 23166678.665957645 1.0 0.3848417085254232 0.2934970492475787 26.234129984583607 -13.999999999999998 0.2685688262851997 5.711741685616371 0.2627534099097323 0.9995802603777256 0.006427814771247584 14.81334409084991 0.16404080536212318 38.07569237921907 0.03821060071300956 1.0000000000000041e-14 13.999999999999998 -5.448988275706639 ELQSK(ub)EFLSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELQSKEFLSAK 11 1 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 115383000.0 34722000.0 52989000.0 27672000.0 True False 28872881.445411135 52703537.739507 33458087.259128083 1.0 1.8253646709682088 1.1588066581572756 24.783211756529685 -10.292492879593135 4.868395149708098 0.9998231453512755 1.4920856645631444 0.42085448149029325 0.27212116922644114 0.0005225414142001453 7.593921431235319e-05 0.26357382695705966 0.0878267297135103 5.099259579171675e-11 10.292492879593135 0.4922625192118689 ELQSK(ub)EFLSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELQSKEFLSAK 11 1 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 288909000.0 92900000.0 105895000.0 90114000.0 True False 120260881.33277293 100001850.16081375 73714176.64772217 1.0 0.8315409720314574 0.6129522404192953 26.84159219558571 -6.967554200225733 0.3111122146398527 1.033236159897281 0.40429756128628036 0.9999565297657406 0.0010446940477339011 0.07710457233928576 0.011856787230470388 0.0034412710821865055 0.019385703402148884 1.0775707637901441e-07 6.967554200225733 -0.6289385986110007 ELQSK(ub)EFLSAK(ub)EETPGAGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELQSKEFLSAKEETPGAGQK 20 2 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 2 12044500.0 4212900.0 2888100.0 4943500.0 True False 5523152.69778164 2457206.7377256253 4431994.041400427 1.0 0.44489205209056704 0.8024391654390663 22.397060583259865 -10.090456829166035 5.376158170434495 1.0000048498222178 0.6236656087645768 0.5963077267183837 0.1459679977857008 8.485192543751655e-06 1.435546542218196e-06 0.1413347262754787 0.047110968708476794 8.119759590035686e-11 10.090456829166035 -0.37633924105764105 ELQSK(ub)EFLSAK(ub)EETPGAGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELQSKEFLSAKEETPGAGQK 20 2 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 2 30538700.0 6696700.0 12574000.0 11268000.0 True False 10159383.494348561 10330071.458889585 9040874.861060163 1.0 1.0168010159903869 0.8899038869917058 23.276309521377495 -6.873556648841043 1.1151775980422873 1.009739361787457 0.8819542951984763 0.9681024324401396 0.010051432432298057 0.13348700339477562 0.30812356384720613 0.00697912315683038 0.01663243065275005 1.3379606818164052e-07 6.873556648841043 -0.1277850665889807 ELQSK(ub)EFLSAK(ub)EETPGAGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELQSKEFLSAKEETPGAGQK 20 2 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 2 11477700.0 4212900.0 2306800.0 4958000.0 True False 5770522.979341679 2204877.948432503 3787022.5132152312 1.0 0.38209326196705357 0.6562702421899492 22.460270644782756 -10.419122490683161 6.05427175599328 1.0001462819170546 0.5191817520785367 0.8039414523735684 0.11193228346054199 0.00022107523445811115 2.1210912415169977e-05 0.10841048596793271 0.036125989145470494 3.809583607547429e-11 10.419122490683161 -0.4809645298385179 ELQSK(ub)EFLSAK(ub)EETPGAGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELQSKEFLSAKEETPGAGQK 20 2 Q8NBI5;E9PS74;H0YD64;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 2 24816800.0 6696700.0 7751100.0 10369000.0 True False 8669010.161691936 7319744.471235496 8481948.394924542 1.0 0.8443575834737397 0.9784217848083725 23.047435843469945 -10.176312609349726 5.788825007737923 1.0000015111310163 0.9113896841464755 0.36808081998251396 0.054731481007276095 1.0674793928779295e-06 1.5183171991266772e-07 0.052994432773145556 0.01766450953786932 6.663269679842095e-11 10.176312609349726 -0.08861182698454084 ELRDEEQTAESIK(ub)NQMTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELRDEEQTAESIKNQMTVK 19 2 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 11293200.0 2574600.0 4994200.0 3724400.0 True False 3375325.5324618663 4249084.827239127 3339034.814967489 1.0 1.258866674154527 0.9892482318681991 21.68659521857514 -6.655423952815701 1.9893313203734955 1.1672530137700103 0.9903825007049457 0.21631263266780876 0.11034112182936873 0.4953472360855079 3.763460266299578 0.04489086552394584 0.12225099236154813 2.2109353684931365e-07 6.655423952815701 -0.17687051306506463 ELRDEEQTAESIK(ub)NQMTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELRDEEQTAESIKNQMTVK 19 2 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 11858400.0 2574600.0 6329700.0 2954100.0 True False 3526499.195948889 6050032.924481196 2256402.4215992587 1.0 1.7155917492994892 0.6398420348971948 21.74980528009803 -6.7273901135434215 1.732637197914094 1.4318977507726087 0.6407769991246026 0.5470898898155904 0.30088676276752074 0.34119641047210525 2.005412826700901 0.13768213791987285 0.3426772465915369 1.873311013674189e-07 6.7273901135434215 -0.7911207516480061 ELRDEEQTAESIK(ub)NQMTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELRDEEQTAESIKNQMTVK 19 2 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 4107700.0 1377300.0 1682600.0 1047800.0 True False 1145285.974735463 1673535.4998300483 1266890.1355201812 1.0 1.4612380983855144 1.1061779882642901 20.12727644958443 -10.04970982664601 5.455055931792434 0.9999981422598124 1.2837080433251193 0.45983653423636917 0.14495268296966377 3.274960963974821e-06 5.704813164664355e-07 0.14035075191490223 0.04678327726068877 8.91846625395283e-11 10.04970982664601 0.2837099010653069 ELSANTAAFAK(ub)SAAMLGNSEDHTALSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELSANTAAFAKSAAMLGNSEDHTALSR 27 1 O60749;O60749-2 O60749 SNX2 Sorting nexin-2 1 7500000.0 2633200.0 2270400.0 2596400.0 True False 2549610.5073408047 3176982.559979592 1916324.9496696151 1.0 1.2460658405793614 0.75161478357269 21.281845439135115 -6.771363326846073 1.5690132101724277 1.1408861729093396 0.7486731699019434 0.7358627928668127 0.10374425764132429 0.2642112176811358 1.283809007836432 0.05210997445414314 0.12390010753576394 1.6929209254820358e-07 6.771363326846073 -0.39221300300739614 ELSDAVNVRDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELSDAVNVRDR 11 1 B8ZZD4;Q86VP1-3;Q86VP1-4;Q86VP1-2;Q86VP1 B8ZZD4 TAX1BP1 Tax1-binding protein 1 0 13539600.0 4585500.0 6191100.0 2763000.0 False True 6011634.906045174 5267412.012718785 2477111.264567493 1.0 0.8762029123594957 0.41205284473888487 22.519325964601087 -6.946363911825934 0.5974392234790404 1.0052588120598236 0.2593415366589273 0.9988840903782829 0.008454176061567837 0.08497969407269347 0.04226560890604393 0.008698924564900857 0.038973719477622126 1.1314518794424148e-07 6.946363911825934 -0.7459172754008963 down ELSDAVNVRDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELSDAVNVRDR 11 1 B8ZZD4;Q86VP1-3;Q86VP1-4;Q86VP1-2;Q86VP1 B8ZZD4 TAX1BP1 Tax1-binding protein 1 0 17242900.0 5732900.0 7824900.0 3685100.0 False True 5550912.2275308 10949423.376314428 2719861.759369701 1.0 1.972544858844766 0.48998464538495706 22.404293450334464 -6.729711045639899 1.724080105097878 1.5854450740262849 0.4908765126127053 0.5580497324439568 0.4088430749888971 0.33676306781627346 1.960905521266878 0.1879243002780628 0.4665102612104404 1.8633264736922756e-07 6.729711045639899 -1.0945685614135796 ELSDAVNVRDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELSDAVNVRDR 11 1 B8ZZD4;Q86VP1-3;Q86VP1-4;Q86VP1-2;Q86VP1 B8ZZD4 TAX1BP1 Tax1-binding protein 1 0 15809800.0 10517000.0 3541500.0 1751300.0 False True 15955057.89568946 2909491.6551342015 1405154.7873779435 1.0 0.18235544328048173 0.08806955114575742 23.927510507906952 -13.999999999999998 0.30485872183118123 8.67046496716561 0.06601776670693305 0.9996606416378155 0.007543269986646461 16.911935077544104 0.1755020954906909 82.05218326557355 0.03337793027374793 1.0000000000000041e-14 13.999999999999998 -8.604447200458678 ELSDAVNVRDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELSDAVNVRDR 11 1 B8ZZD4;Q86VP1-3;Q86VP1-4;Q86VP1-2;Q86VP1 B8ZZD4 TAX1BP1 Tax1-binding protein 1 0 10416800.0 4585500.0 3370600.0 2460700.0 False True 6280883.268478073 3221675.7469163314 1879533.3397072875 1.0 0.512933549184871 0.29924665996263916 22.58253602612398 -11.931336114074188 0.13894760729580607 2.3463781862690283 8.80774919307642e-14 0.9996665553248143 0.005354847846654092 5.273149306045472 0.09470460229625312 2.3060710031187193 0.22940508554082506 1.1712885178798326e-12 11.931336114074188 -2.3463781862689403 ELSDAVNVRDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELSDAVNVRDR 11 1 B8ZZD4;Q86VP1-3;Q86VP1-4;Q86VP1-2;Q86VP1 B8ZZD4 TAX1BP1 Tax1-binding protein 1 0 18865300.0 5732900.0 11815000.0 1317400.0 False True 4767160.360532148 11751350.249906106 1592862.2490306213 1.0 2.465062922404886 0.33413229859396076 22.18469872576874 -6.721696364608806 1.7532235552923856 1.8897179711065548 0.3371396945442335 0.5204755775379397 0.6163803816511989 0.35204726137665343 2.1157165027666123 0.27905346979051576 0.6991315165003372 1.8980324598547303e-07 6.721696364608806 -1.5525782765623213 ELSDFISYLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELSDFISYLQR 11 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 66689000.0 15725000.0 30726000.0 20238000.0 False True 20615627.281116612 26141800.569009922 18143965.89660403 1.0 1.2680574892307614 0.8801073888847146 24.297235023646973 -6.720830961606841 1.756401986602343 1.1629405164628428 0.8806876526206555 0.5163727333774487 0.1127884843041282 0.3537203869799216 2.1330395345369206 0.05098003658994542 0.1278503439471959 1.9018183716790196e-07 6.720830961606841 -0.2822528638421873 ELSDFISYLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELSDFISYLQR 11 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 156597000.0 59616000.0 29192000.0 67789000.0 False True 57723522.71214858 40848517.8342689 50033027.273591645 1.0 0.7076580900644143 0.8667701644456571 25.78265601054563 -10.083104001272355 4.872231329034717 1.0000072545950216 0.7872141276509548 0.7045453097395842 0.06495723236446053 17089344.40634352 35366472.85521212 849.2015141078275 0.02223658867772098 8.258401604829585e-11 10.083104001272355 -0.21279312694406682 ELSDFISYLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELSDFISYLQR 11 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 121247000.0 15725000.0 45029000.0 60493000.0 False True 21538957.452146456 43039469.88900952 46205799.29244235 1.0 1.998215093958526 2.145219860111555 24.360445085169864 -10.81962070507451 0.36622704455975014 2.73987518788859e-12 2.1659821664889387 0.9993433470214116 0.01303721294281423 2.4954392598722124 0.17918327991577954 2.2145505242894905 0.041433715707877794 1.514883707941144e-11 10.81962070507451 2.1659821664861987 ELSDFISYLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELSDFISYLQR 11 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 100572000.0 59616000.0 23645000.0 17311000.0 False True 49573345.43660012 23517619.691834986 20930650.062979434 1.0 0.47440049657152794 0.42221580727788216 25.563061285979906 -13.999999999999998 0.3265195270409444 6.603051905947935 0.4125930443578399 0.9997075721594108 0.00446222641162201 18.53357626913904 0.18254431397113274 71.18460960580664 0.016943297668616523 1.0000000000000041e-14 13.999999999999998 -6.190458861590095 ELSDIAHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELSDIAHR 8 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 28658800.0 10140000.0 3075800.0 15443000.0 False True 9818111.250355382 4303982.980085104 11398015.019930614 1.0 0.43837178764187607 1.1609172812660933 23.227014083494694 -6.699289904032912 1.833973836955652 0.6509996790888145 1.1586999493713657 0.41399132629856084 0.23710184369355713 0.39697742736069946 2.595495374896571 0.10317244706245723 0.26550879538111155 1.9985273498942363e-07 6.699289904032912 0.5077002702825512 ELSELVYTDVLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELSELVYTDVLDR 13 0 Q8WU39 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 43524600.0 6772600.0 14903000.0 21849000.0 False True 8878944.1859517 12679530.491438998 19588275.070407216 1.0 1.4280448469876181 2.206149138925759 23.081956702177425 -6.961868909166031 0.40824120050563406 0.9609269855425838 2.7020607095399396 0.9998333562694657 0.00644514443623776 0.07904014125706017 0.01871340802339981 0.010015278296710992 0.06500335271837504 1.0917698350399914e-07 6.961868909166031 1.7411337239973559 up ELSELVYTDVLDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELSELVYTDVLDR 13 0 Q8WU39 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 51183600.0 6772600.0 21770000.0 22641000.0 False True 9276613.242633207 20808129.416237075 17293662.1060319 1.0 2.243073940024538 1.864221527157579 23.145166763700317 -10.17550631120045 5.8340362945276025 0.9999836857404281 2.053647733591083 0.9116069476716031 0.15466584989113302 3.2820115523206555e-05 4.637951799347345e-06 0.1497568764614112 0.04991818840460182 6.675651997855479e-11 10.17550631120045 1.0536640478506551 ELSFTK(ub)SSQAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELSFTKSSQAVR 12 1 Q96LD4;Q96LD4-2 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 13304300.0 4685900.0 6547500.0 2070900.0 True False 6143260.278320146 5570638.521955098 1856623.1334755046 1.0 0.9067886219332336 0.3022211414397685 22.55057307818143 -6.93420950458155 0.7113873357269828 1.0079152853812312 0.1636610056491102 0.9973028787556478 0.016063940952260946 0.09051015568503705 0.06739835152219026 0.015020528946501825 0.053493391437378524 1.1635645879696771e-07 6.93420950458155 -0.844254279732121 down ELSFTK(ub)SSQAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELSFTKSSQAVR 12 1 Q96LD4;Q96LD4-2 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 14467400.0 5171800.0 4116400.0 5179200.0 True False 5007624.039900198 5760099.986742411 3822612.147330488 1.0 1.1502660624772483 0.7633584544031929 22.25569482166421 -6.8013748896852455 1.4501621947071484 1.0827645011345037 0.7578261695448542 0.8361901903860924 0.0644583822801101 0.21879896601072252 0.9082370560130932 0.03496463480698697 0.0812524680059096 1.579883670567217e-07 6.8013748896852455 -0.3249383315896496 ELSFTK(ub)SSQAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELSFTKSSQAVR 12 1 Q96LD4;Q96LD4-2 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 110935200.0 9910000.0 7212200.0 93813000.0 True False 15034194.518045336 5925126.560824198 75270819.43030138 1.0 0.3941100105969994 5.006641316231133 23.841744239409735 -6.873832012456329 1.113562190121393 0.6479108481986933 5.297275849631241 0.9683633075650555 0.36401586872886654 0.13323689765005065 0.3064630697915718 0.25304785774112704 0.6034504229450207 1.3371126191983682e-07 6.873832012456329 4.649365001432548 up ELSFTK(ub)SSQAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELSFTKSSQAVR 12 1 Q96LD4;Q96LD4-2 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 12525730.0 4685900.0 3681300.0 4158530.0 True False 6418403.8616860425 3518647.9935688335 3176370.8616137467 1.0 0.5482123078251614 0.4948848545624784 22.61378313970432 -13.999999999999998 0.30149350927660407 5.156641690255221 0.48196550361726864 0.9996531603084239 0.004219970595764529 16.686363754929356 0.17442488228566824 43.30449355701173 0.019149255827382566 1.0000000000000041e-14 13.999999999999998 -4.674676186637952 ELSFTK(ub)SSQAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELSFTKSSQAVR 12 1 Q96LD4;Q96LD4-2 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 17552700.0 5171800.0 7894700.0 4486200.0 True False 4300580.849587504 7852169.684124745 5424243.678154825 1.0 1.8258393363021874 1.2612816426123228 22.036100097098487 -9.81450331693376 6.311646852126389 0.9999999821525586 1.543560489457474 0.5527724483291803 0.2304797133178913 5.7938369131419935e-08 1.10640743227834e-08 0.22316102948006902 0.07438700760978918 1.5328394992224803e-10 9.81450331693376 0.5435605073049153 ELSFTK(ub)SSQAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELSFTKSSQAVR 12 1 Q96LD4;Q96LD4-2 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 75363100.0 9910000.0 6243100.0 59210000.0 True False 12828690.355304409 5895665.996874043 48434387.545904346 1.0 0.4595688128395976 3.775474051088753 23.612870561502184 -6.8651026971375115 1.159759402941475 0.7017908226304881 3.952363148602544 0.9595423353034667 0.29217827298838306 0.14163303140788322 0.3591509059571641 0.19605245110212888 0.4605829225032857 1.364260493267544e-07 6.8651026971375115 3.250572325972056 up ELSGTIK(ub)EILGTAQSVGCNVDGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELSGTIKEILGTAQSVGCNVDGR 23 1 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 1 49633000.0 18752000.0 13876000.0 17005000.0 True False 28448154.954832066 11399719.386317171 13643954.29644372 1.0 0.40071911181645437 0.479607704545571 24.76183175175813 -10.627325400069063 6.571341205416302 1.0019910828262677 0.44016340818157773 0.9853260479197857 0.0322061331187618 0.0009419560762894268 5.342028525914427e-05 0.03126591196433357 0.010394484767891975 2.3587102804890076e-11 10.627325400069063 -0.56182767464469 ELSGTIK(ub)EILGTAQSVGCNVDGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELSGTIKEILGTAQSVGCNVDGR 23 1 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 1 46805000.0 18752000.0 16118000.0 11935000.0 True False 24274833.657181427 15221019.13113929 9762952.46344145 1.0 0.6270287716940267 0.4021841138570766 24.53295807385058 -9.023057241508972 0.14471312251464022 1.5170736116286625 1.2300103144409721e-13 0.9998615376598126 0.002901054164349338 0.4901614755838503 0.04709636559459965 0.2833693981310977 0.17490811044218318 9.482934667175564e-10 9.023057241508972 -1.5170736116285395 ELSIHFVPGSCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELSIHFVPGSCR 12 0 Q9NZL9;H7C0X7;Q9NZL9-3;E5RJR3 Q9NZL9 MAT2B Methionine adenosyltransferase 2 subunit beta 0 22461300.0 6786400.0 5384900.0 10290000.0 False True 8897036.119591096 4581493.910175804 9225289.508649834 1.0 0.5149460841332818 1.036894689944658 23.0848933786932 -11.910982906442147 17.980801287736295 0.9031564456754909 0.7983283483350732 0.0 0.2435096590133368 0.0 0.0 0.0 0.07078064189975138 1.2274875433458611e-12 11.910982906442147 -0.10482809734041776 ELSIHFVPGSCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELSIHFVPGSCR 12 0 Q9NZL9;H7C0X7;Q9NZL9-3;E5RJR3 Q9NZL9 MAT2B Methionine adenosyltransferase 2 subunit beta 0 10102000.0 4662200.0 1733100.0 3706700.0 False True 4514201.012959253 2425135.8679971052 2735804.071383593 1.0 0.5372237215478636 0.606043918631385 22.106039231084463 -10.603806982330363 6.483142715319696 1.0011567494428826 0.5716338200896679 0.9810095185044779 0.028095727808733737 0.00047087796565524774 2.8775934492086694e-05 0.027268880794598296 0.009067857158566858 2.4899637108994012e-11 10.603806982330363 -0.4295229293532147 ELSIHFVPGSCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELSIHFVPGSCR 12 0 Q9NZL9;H7C0X7;Q9NZL9-3;E5RJR3 Q9NZL9 MAT2B Methionine adenosyltransferase 2 subunit beta 0 20464900.0 4368300.0 9498400.0 6598200.0 False True 5654850.462066218 8969805.69023536 5397395.303249214 1.0 1.5862144808967935 0.9544718007055958 22.43105744314352 -6.662883479642197 1.9620239742911683 1.3764153790701492 0.9570517974349029 0.24827790029411356 0.24942087121511097 0.477592387338036 3.5370286579612378 0.10258348289455084 0.2767041204874434 2.1732841885358446e-07 6.662883479642197 -0.41936358163524634 ELSK(ub)QVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELSKQVPK 8 1 P33552 P33552 CKS2 Cyclin-dependent kinases regulatory subunit 2 1 3306380.0 873880.0 1354600.0 1077900.0 True False 1145665.1426659592 1152498.9601894442 966369.247946906 1.0 1.0059649344900052 0.8435006110931924 20.12775400119505 -6.898377180690646 0.971484032909356 1.0070587201870969 0.8269991048419343 0.9857410787891818 0.008982060542963423 0.11260921392078731 0.18423947171670263 0.006955050884071403 0.017952659798535987 1.2636384126388818e-07 6.898377180690646 -0.18005961534516257 ELSK(ub)QVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELSKQVPK 8 1 P33552 P33552 CKS2 Cyclin-dependent kinases regulatory subunit 2 1 3185570.0 873880.0 877190.0 1434500.0 True False 1196977.0517190313 838432.8453205774 1095700.644454871 1.0 0.7004585794827621 0.915389850524943 20.190964062717942 -9.903188501018784 5.65904561164335 1.0000001192795682 0.8079242159046042 0.5157012030261965 0.0877453239715265 1.320552141090592e-07 2.5614894214095857e-08 0.08495909778307252 0.028319681537247707 1.2497164859948724e-10 9.903188501018784 -0.19207590337496405 ELSK(ub)QVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELSKQVPK 8 1 P33552 P33552 CKS2 Cyclin-dependent kinases regulatory subunit 2 1 6154200.0 1929000.0 2413100.0 1812100.0 True False 1604048.9691895077 2400100.1513371533 2191001.731796257 1.0 1.4962761096688175 1.365919478694796 20.613286755087373 -9.967293998515283 4.68604226355848 0.9999942440078157 1.4310977940784098 0.9358243514313482 0.05321787185284708 36557505.73964003 0.28592581422040475 2461.855971846197 0.01821789303156094 1.0782165692954286e-10 9.967293998515283 0.4311035500705941 ELSK(ub)QVPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELSKQVPK 8 1 P33552 P33552 CKS2 Cyclin-dependent kinases regulatory subunit 2 1 17300600.0 1309400.0 2720200.0 13271000.0 True False 1695044.1121327528 2568818.478752021 10855814.171959063 1.0 1.5154876857569568 6.4044434562236665 20.69289138812949 -6.927074540362625 0.7704230837317984 0.9170335981268471 7.337238262718952 0.995931436992742 0.15533551274613008 0.09418561147795809 0.08533131601356911 0.13912894420310676 0.4496921164167245 1.1828385211877989e-07 6.927074540362625 6.420204664592104 up ELSLLLQVEQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELSLLLQVEQR 11 0 Q8NB16;I3L2T9;Q8NB16-2 Q8NB16 MLKL Mixed lineage kinase domain-like protein 0 8882700.0 2422200.0 2567400.0 3893100.0 False True 3674654.486539798 2109227.4108122434 3123627.0785936527 1.0 0.5739933968046004 0.8500464710452235 21.809177174650188 -10.118641013037593 5.139047268324399 1.000008511712238 0.7120199339244752 0.5920093822733579 0.11269819563755056 1.099085564170678e-05 1.884921969536412e-06 0.10912278364610631 0.03637318623743614 7.60955020964989e-11 10.118641013037593 -0.28798857778776277 ELSNFYFSIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELSNFYFSIIK 11 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 2824000.0 0.0 0.0 2824000.0 False True 0.0 0.0 2531799.569720807 0.0 ELSNFYFSIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELSNFYFSIIK 11 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 3405600.0 0.0 3405600.0 0.0 False True 0.0 3255129.3311868114 0.0 0.0 ELSQK(ub)TPPSMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 ELSQKTPPSMR 11 1 O96019;O96019-2;O94805 O96019 ACTL6A;ACTL6B Actin-like protein 6A;Actin-like protein 6B 1 37030460.0 7848860.0 11321400.0 17860200.0 True False 10289931.468468368 9632291.250471551 16012197.831135856 1.0 0.9360889603577986 1.5561034473555375 23.294730038043994 -6.881474605193125 1.071577317870835 0.9595647815569586 1.6012987052411212 0.9748540239200556 0.044153388919896605 0.12633023537613902 0.2644806094424684 0.03169801639583212 0.07694693531407326 1.3137883147827805e-07 6.881474605193125 0.6417339236841626 ELSQK(ub)TPPSMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 ELSQKTPPSMR 11 1 O96019;O96019-2;O94805 O96019 ACTL6A;ACTL6B Actin-like protein 6A;Actin-like protein 6B 1 44672300.0 2334340.0 2244360.0 40093600.0 True False 2260237.6544531137 3140544.6521827807 29591883.377782155 1.0 1.3894754146738901 13.092376954025305 21.108043043236773 -6.913976036720525 0.8682262825687318 0.6816144290831707 14.740788979564298 0.9923373973844555 0.491153388567282 0.1018469223444322 0.12494184408401042 0.410193030018284 1.1660715654469918 1.2190568615670655e-07 6.913976036720525 14.059174550481128 up ELSQK(ub)TPPSMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELSQKTPPSMR 11 1 O96019;O96019-2;O94805 O96019 ACTL6A;ACTL6B Actin-like protein 6A;Actin-like protein 6B 1 88442700.0 10215800.0 22150400.0 56076500.0 True False 15498115.475019932 18197488.05813489 44992955.1957969 1.0 1.1741742463763316 2.9031242713552587 23.885589462928134 -6.926316222909492 0.7764325573393256 0.9698090974901209 3.2269194632737195 0.995763441893431 0.055913668227512404 0.09459609998788716 0.08738461244708601 0.04986512749006471 0.15972574500539694 1.1849056684371692e-07 6.926316222909492 2.2571103657835985 up ELSQK(ub)TPPSMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELSQKTPPSMR 11 1 O96019;O96019-2;O94805 O96019 ACTL6A;ACTL6B Actin-like protein 6A;Actin-like protein 6B 1 5920700.0 1120200.0 1272800.0 3527700.0 True False 1534368.2122667392 1216563.4874132532 2694529.915262075 1.0 0.792875841461816 1.756116878413048 20.549213306575847 -6.850436872625675 1.2329258759786303 0.8894260784262168 1.7949610854574534 0.9409467370526531 0.10060179768866048 0.1569762343843127 0.45895795472861856 0.06384049566446685 0.14777743675294586 1.411117336136189e-07 6.850436872625675 0.9055350070312366 ELSQK(ub)TPPSMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ELSQKTPPSMR 11 1 O96019;O96019-2;O94805 O96019 ACTL6A;ACTL6B Actin-like protein 6A;Actin-like protein 6B 1 38873640.0 2334340.0 17212200.0 19327100.0 True False 1941107.1387961796 17119474.4622458 23368307.251586247 1.0 8.819438206209895 12.03864886411093 20.88844831867105 -8.75142375222709 0.43991778088044586 3.90246115861881e-13 12.457036379449812 0.9964966504449656 0.2743483420029648 0.31982441937903966 0.15477168205051034 1.4000361927945795 0.735941369630258 1.772459203138601e-09 8.75142375222709 12.457036379449422 ELSQK(ub)TPPSMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ELSQKTPPSMR 11 1 O96019;O96019-2;O94805 O96019 ACTL6A;ACTL6B Actin-like protein 6A;Actin-like protein 6B 1 69359800.0 12763100.0 13946400.0 42650300.0 True False 16522084.548313398 13170270.580129128 34888383.029033706 1.0 0.7971312906441682 2.1116211412073405 23.977892383522793 -6.8675001421632516 1.147170448146585 0.8868182337990674 2.185055087449833 0.9621275027125644 0.11244605575874377 0.13927797337598538 0.3441213667929656 0.07617837025107518 0.17962193587950082 1.3567500861771675e-07 6.8675001421632516 1.2982368536507654 up ELSTTLNADEAVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELSTTLNADEAVTR 14 0 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 0 11536500.0 2583800.0 5979700.0 2973000.0 False True 3387386.821554791 5087552.068688042 2665382.4790297323 1.0 1.5019105690305794 0.7868550654059453 21.691741313662455 -6.71807709917427 1.7664476513181162 1.30599143143238 0.7881069817637528 0.5032827251141683 0.21125816332846728 0.35909196336978283 2.1887883387217246 0.09500298242964506 0.23901488845447866 1.9139161222889148e-07 6.71807709917427 -0.5178844496686271 ELSTTLNADEAVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELSTTLNADEAVTR 14 0 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 0 6812600.0 3017400.0 0.0 3795200.0 False True 2921614.2886412516 0.0 2801123.2664405005 1.0 0.0 0.9587587510544427 21.478334295516568 -11.86647614759011 13.56394866320528 0.8555066423720308 0.5314414379744675 0.0 0.477694886617374 0.0 0.0 0.0 0.13575151610365807 1.3599528528407037e-12 11.86647614759011 -0.32406520439756326 ELSYPK(ub)NESFNNQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELSYPKNESFNNQSR 15 1 Q8N5U6;Q8N5U6-2;F5H5P6;H0YGL7 Q8N5U6 RNF10 RING finger protein 10 1 6680100.0 1481000.0 2173600.0 3025500.0 True False 1231517.1194243964 2161890.38537418 3658118.06166855 1.0 1.7554692105170526 2.970415923554788 20.232005252327117 -6.964074103728226 0.3736063452072737 0.9103072085202961 3.858108852858443 0.9998927628565126 0.00840534356292784 0.07827662356184847 0.01597674995287468 0.015931517023671078 0.10298888569986178 1.0862402624754123e-07 6.964074103728226 2.947801644338147 ELTAVVQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELTAVVQKR 9 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 192115000.0 47734000.0 25880000.0 118501000.0 True False 62579736.25671352 22018804.879449874 106239653.26185761 1.0 0.35185199229866854 1.697668600360397 25.899192242542156 -6.7757473063929075 1.5524312677325618 0.6309747993124073 1.706943405065045 0.7520574819533237 0.27364262088168395 0.2572385218092048 1.2241907531604377 0.1388759602814185 0.32887415172951495 1.6759177226603931e-07 6.7757473063929075 1.0759686057526376 ELTAVVQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELTAVVQKR 9 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 289717000.0 63131000.0 58104000.0 168482000.0 True False 61126940.96116222 81305230.20835707 124351509.84834243 1.0 1.3301046793755864 2.0343159316176274 25.86530503483813 -6.958763956453505 0.45252386443467824 0.977867398150179 2.4145879026607058 0.9997215532633393 0.007198087953917318 0.08014575162805988 0.02278597517182091 0.009448590952791163 0.05822873722630241 1.0996033228370633e-07 6.958763956453505 1.436720504510527 up ELTAVVQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELTAVVQKR 9 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 370114000.0 61052000.0 59298000.0 249764000.0 True False 92620347.49906182 48715808.6026114 200398035.92454988 1.0 0.5259730709076087 2.1636502273604594 26.464825834060665 -6.829271591389113 1.3311526231914002 0.7465827789212227 2.2070708866757713 0.904415974935457 0.21272348558021406 0.1817082329852217 0.6299667511463034 0.12548136125706474 0.28877849707485387 1.4815912640798928e-07 6.829271591389113 1.4604881077545486 up ELTAVVQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELTAVVQKR 9 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 298664000.0 47734000.0 41150000.0 209780000.0 True False 65382549.76284633 39331856.93514723 160234284.55471784 1.0 0.6015650518037396 2.45071942186279 25.962402304065048 -6.850309383102364 1.2334914906020928 0.7873096331448585 2.5251253406035743 0.9407648955331551 0.1933953546721505 0.1571205306643371 0.4598580694302678 0.12267085673113824 0.28394250274886557 1.411531638164672e-07 6.850309383102364 1.737815707458716 up ELTAVVQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELTAVVQKR 9 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 315499000.0 63131000.0 129439000.0 122929000.0 True False 52496223.67750265 128741686.41537002 148632885.54052326 1.0 2.4523989993311175 2.8313062374469453 25.645710310272406 -10.099571525325025 0.31730013165318 4.784157400239557e-25 2.940909748644404 0.9989038626004983 0.026131570705913217 1.512494066255229 0.14434511891607502 1.4721979132419982 0.1259767102375832 7.951123052016563e-11 10.099571525325025 2.940909748644404 ELTAVVQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELTAVVQKR 9 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 313243000.0 61052000.0 63672000.0 188519000.0 True False 79033017.51483792 60128597.22781363 154210476.36828822 1.0 0.7608035112226974 1.9512158489878768 26.235952156153115 -6.854430311718734 1.213472464660531 0.87169279487646 2.0030442897972836 0.9465145589506464 0.1189059595617826 0.15264905759181943 0.43032083441986224 0.07657807669223904 0.1777886303102613 1.3982012571676057e-07 6.854430311718734 1.1313514949208234 ELTDEEAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELTDEEAER 9 0 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 0 8830910.0 2983600.0 899110.0 4948200.0 False True 2888887.251140068 1258129.3117967083 3652117.977181942 1.0 0.43550654713166853 1.2641954010980088 21.46208246814007 -6.723293290162142 1.7471599522877748 0.6577740739801179 1.2631710431573335 0.5280289585734266 0.2374523444006019 0.3490187913309133 2.083792623300916 0.10783188748043594 0.269686687507923 1.891066102058303e-07 6.723293290162142 0.6053969691772156 ELTGLK(ub)ALYETELADAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELTGLKALYETELADAR 17 1 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 14572400.0 7427000.0 3762300.0 3383100.0 True False 7191233.950334263 5264606.010135309 2496964.6191755016 1.0 0.7320865996705057 0.3472233884227112 22.77780791457636 -6.965965870286916 0.34106921767765663 1.0412302748118014 0.025268894254144907 0.9999316928170159 0.002214275315653725 0.0776347074219683 0.013712668224091675 0.005415301581672051 0.03328561833036102 1.0815189408207851e-07 6.965965870286916 -1.0159613805576566 down ELTGLK(ub)ALYETELADAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELTGLKALYETELADAR 17 1 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 2405700.0 0.0 0.0 2405700.0 True False 0.0 0.0 1837523.206946729 0.0 ELTGLK(ub)ALYETELADAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELTGLKALYETELADAR 17 1 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 15472700.0 7427000.0 5059700.0 2986000.0 True False 6175879.571887229 5032442.39182819 3610358.794295909 1.0 0.8148543593265652 0.5845902194612667 22.558213190010637 -6.96818374950165 0.2983953871790309 1.0407047409454242 0.3515411037698073 0.9999645470274906 0.0010117484285736393 0.07689653167333933 0.011128286686702875 0.003850890433871736 0.02068674949527308 1.0760098587583758e-07 6.96818374950165 -0.6891636371756169 ELTIGSK(ub)LQDAEIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELTIGSKLQDAEIAR 15 1 R4GN98;P06703 R4GN98 S100A6 Protein S100;Protein S100-A6 1 58563000.0 17059000.0 17868000.0 23636000.0 True False 22364514.19959097 15202164.048918491 21190373.452521626 1.0 0.6797448812546318 0.9474998322525235 24.414708084773903 -10.038384008367057 6.665449158021764 1.0000000725758689 0.8136223577457476 0.3924769231491295 0.10931050100812666 1.1798970603945505e-07 1.70361345864e-08 0.10583948007491964 0.035279812497504996 9.154107150826611e-11 10.038384008367057 -0.18637771483012122 ELTIGSK(ub)LQDAEIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELTIGSKLQDAEIAR 15 1 R4GN98;P06703 R4GN98 S100A6 Protein S100;Protein S100-A6 1 79142000.0 21455000.0 20040000.0 37647000.0 True False 20773922.768873252 28042076.50721943 27786121.314208876 1.0 1.349869103645483 1.3375481185403462 24.30827033223974 -10.083804772218716 4.568161960473029 0.9999775683952202 1.3437086111053709 0.9990371613277127 0.00503002114846337 1.149221950283184e-06 2.3048273253721547e-07 0.004870614554172957 0.001623432338942182 8.245086719304019e-11 10.083804772218716 0.34373104271015065 ELTIGSK(ub)LQDAEIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELTIGSKLQDAEIAR 15 1 R4GN98;P06703 R4GN98 S100A6 Protein S100;Protein S100-A6 1 63423000.0 17059000.0 18908000.0 27456000.0 True False 23366173.302140925 18072582.039605435 20971458.274069697 1.0 0.7734506547526777 0.8975135980930257 24.477918146296794 -10.123889677316797 4.683236679433838 1.0000129772026145 0.8354821264206352 0.7010163679833878 0.05064848453620657 70678226.24095842 1.437945323629046 9890.750606560157 0.01733832342631728 7.5181385105515e-11 10.123889677316797 -0.16453085078197927 ELTIGSK(ub)LQDAEIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELTIGSKLQDAEIAR 15 1 R4GN98;P06703 R4GN98 S100A6 Protein S100;Protein S100-A6 1 79471000.0 21455000.0 34796000.0 23220000.0 True False 17840783.117657267 34608547.0415348 28075194.64285035 1.0 1.939855824337792 1.5736525946029771 24.088675607674016 -10.171906279986706 4.700584564082933 0.9999121941865234 1.7567542093835673 0.8506085746731062 0.14950184261332744 104807094.14372459 20.172883490788145 109946.93761128583 0.05117845722477163 6.731218991774243e-11 10.171906279986706 0.7568420151970439 ELTIGSK(ub)LQDAEIAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELTIGSKLQDAEIAR 15 1 R4GN98;P06703 R4GN98 S100A6 Protein S100;Protein S100-A6 1 192298000.0 34342000.0 80540000.0 77416000.0 True False 44456395.98202462 76057878.19964996 63327082.35523944 1.0 1.7108421976087087 1.424476297647811 25.40588766004354 -10.102983303887862 4.611799881588459 0.9999676108476072 1.5676592475364008 0.839725083061772 0.11690838926887069 81402379.64850911 1.8157397424231245 35804.90586088959 0.04002085120207504 7.88890445312571e-11 10.102983303887862 0.5676916366887936 ELTQIK(ub)QK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELTQIKQK 8 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 15776900.0 4500100.0 6258500.0 5018300.0 True False 5899674.679030385 5324756.195441928 4499054.454932702 1.0 0.9025508159573732 0.7625936512947057 22.49220397263094 -6.9659699743055965 0.34100557970619133 1.0150046229547813 0.6454816629003279 0.9999317527330981 0.0008049268134306315 0.07763345112152395 0.01370849979259242 0.001969674023095363 0.012105007228849277 1.0815087206748945e-07 6.9659699743055965 -0.3695229600544534 ELTQIK(ub)QK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELTQIKQK 8 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 13430400.0 4500100.0 3850700.0 5079600.0 True False 6163908.580629838 3680563.3414379456 3879903.0976458476 1.0 0.5971151734800486 0.6294550035732998 22.55541403415383 -10.093654542623325 5.418100532313985 1.0000047502882736 0.6132850885264705 0.9947822531313187 0.013202680350177203 7.575999300517895e-07 1.267291455055243e-07 0.012783597387897003 0.0042611467600244335 8.060193303201276e-11 10.093654542623325 -0.38671966176180317 ELTSLVK(ub)EVYPEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELTSLVKEVYPEAR 14 1 O00422;O00422-2;U3KPY7;H7BZW6 O00422 SAP18 Histone deacetylase complex subunit SAP18 1 46847200.0 13134800.0 17485400.0 16227000.0 True False 12717842.963626007 24467411.40515641 11976661.900434759 1.0 1.923864878276533 0.9417211656637778 23.600350664270213 -6.660008449330316 1.9731660624955718 1.594697776400382 0.9458464243975786 0.2354667584329424 0.39336433169899676 0.48445626774264927 3.626008433632626 0.16107505371232628 0.4359789721900154 2.1877190608004244e-07 6.660008449330316 -0.6488513520028034 ELTSLVK(ub)EVYPEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELTSLVKEVYPEAR 14 1 O00422;O00422-2;U3KPY7;H7BZW6 O00422 SAP18 Histone deacetylase complex subunit SAP18 1 95876400.0 38518900.0 21773000.0 35584500.0 True False 58435987.408792816 17887438.036774535 28551207.97775961 1.0 0.30610311949795216 0.4885894676174075 25.800353781021936 -10.829483195889773 10.837206071777699 1.0085534650872903 0.39734629356070367 0.9356567605030334 0.07449973965276104 0.014934456676537367 0.00023498407330522846 0.06997025707393933 0.02404468758099431 1.4808695532872114e-11 10.829483195889773 -0.6112071715265865 ELTSLVK(ub)EVYPEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELTSLVKEVYPEAR 14 1 O00422;O00422-2;U3KPY7;H7BZW6 O00422 SAP18 Histone deacetylase complex subunit SAP18 1 43319300.0 13134800.0 15599600.0 14584900.0 True False 10922168.17030083 15515561.858521845 17634535.157041673 1.0 1.4205569458920444 1.614563599651658 23.38075593970449 -11.326450935884203 0.1390756426211955 2.688341640264629e-19 1.9020210679707301 0.9996899959445542 0.004516421844413318 3.9099011837233317 0.08692081315503426 1.4153036822662945 0.20638437380869282 4.715731439737815e-12 11.326450935884203 1.9020210679707301 ELTSLVK(ub)EVYPEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELTSLVKEVYPEAR 14 1 O00422;O00422-2;U3KPY7;H7BZW6 O00422 SAP18 Histone deacetylase complex subunit SAP18 1 97256900.0 38518900.0 20040000.0 38698000.0 True False 49863475.37103282 18924756.383424222 31655361.0750111 1.0 0.37953143543657164 0.6348406491818788 25.571480103114386 -10.337120778958411 5.810933285272424 1.0000693004524315 0.5071860423092527 0.8324365214500951 0.10422955005119992 9.359129124071971e-05 1.067634807813711e-05 0.10093393116360311 0.0336399426275817 4.601285922627077e-11 10.337120778958411 -0.4928832581431788 ELTVDNSFEFEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELTVDNSFEFEKR 13 1 Q9UHA3;H3BMQ2 Q9UHA3 RSL24D1 Probable ribosome biogenesis protein RLP24 1 3670800.0 821300.0 1681700.0 1167800.0 True False 1076732.2534805147 1430796.915215256 1046967.2583285972 1.0 1.3288325956524796 0.972356177633109 20.038228114843445 -6.664256670466753 1.9578903775083596 1.2109184504868011 0.973831001611421 0.253857719528485 0.13986801796887713 0.4744015902275541 3.5002302248718613 0.05762902874935152 0.15512385645877996 2.1664233580765932e-07 6.664256670466753 -0.23708744887538014 ELTVDNSFEFEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELTVDNSFEFEKR 13 1 Q9UHA3;H3BMQ2 Q9UHA3 RSL24D1 Probable ribosome biogenesis protein RLP24 1 19936200.0 5264200.0 3810000.0 10862000.0 True False 5097090.8524774015 5331352.868887526 8016916.346984809 1.0 1.0459599452295938 1.5728415637496924 22.28124263793934 -6.924061218140929 0.7940031879245559 0.9899875351589791 1.6662913111101347 0.9952373448208575 0.01793521177986195 0.09583986828904076 0.09365322638646584 0.015795486045785123 0.049321202109583025 1.1910741024135312e-07 6.924061218140929 0.6763037759511557 ELTVDNSFEFEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELTVDNSFEFEKR 13 1 Q9UHA3;H3BMQ2 Q9UHA3 RSL24D1 Probable ribosome biogenesis protein RLP24 1 62960000.0 9311200.0 16796000.0 36852800.0 True False 14125771.139901489 13798622.572253028 29568827.92684394 1.0 0.9768403038383968 2.093254069742075 23.75182629204693 -6.902166713153572 0.9475005181745773 0.956302580670059 2.215722881074718 0.9876128879541515 0.05797587652424825 0.10982694277276882 0.16857497432304425 0.045699167075523094 0.12024318786727473 1.252660222424797e-07 6.902166713153572 1.259420300404659 up ELTVDNSFEFEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELTVDNSFEFEKR 13 1 Q9UHA3;H3BMQ2 Q9UHA3 RSL24D1 Probable ribosome biogenesis protein RLP24 1 19457400.0 5264200.0 6567200.0 7626000.0 True False 4377415.543601559 6531821.1901128655 9220561.34135989 1.0 1.4921638407531101 2.106393886876362 22.061647913373616 -6.9681330224544284 0.29944261615856765 0.8927638557918306 2.7250249976271292 0.9999639373420447 0.0027179490051474167 0.07691328113197105 0.01118702244759256 0.010218540929914102 0.05512015038676536 1.0761355476470022e-07 6.9681330224544284 1.8322611418352985 ELTVDNSFEFEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELTVDNSFEFEKR 13 1 Q9UHA3;H3BMQ2 Q9UHA3 RSL24D1 Probable ribosome biogenesis protein RLP24 1 54223200.0 9311200.0 22510000.0 22402000.0 True False 12053531.951191768 21257298.712119706 18325065.86393092 1.0 1.7635742617347885 1.5203067398115675 23.522952614139378 -10.117378944704472 4.755666031461158 0.9999592586183899 1.641940500779675 0.9027666030743445 0.09931354997286583 4.290356374844695e-05 7.962629234467204e-06 0.09616601313860146 0.03205331042163555 7.63169587498224e-11 10.117378944704472 0.6419812421612852 ELVALMSAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELVALMSAIR 10 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 6286200.0 1315500.0 2209700.0 2761000.0 False True 1724633.2393201203 1880021.3733431378 2475318.2053821357 1.0 1.0900992341329767 1.435272235827919 20.717858160158848 -6.945867699750841 0.6025136147612594 0.9961326116835348 1.5469845860126805 0.9988357273375794 0.006400980993015324 0.08518889916879964 0.04316676564195635 0.006553423430644937 0.029031401782890855 1.1327453818308e-07 6.945867699750841 0.5508519743291457 ELVALMSAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELVALMSAIR 10 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 5989600.0 1315500.0 1512600.0 3161500.0 False True 1801875.9000507884 1445768.3305006952 2414818.813136337 1.0 0.8023684264049173 1.3401693274593838 20.78106822168174 -6.807270615197337 1.4262954385391877 0.8919402898805923 1.3489731462684442 0.8524916287196918 0.0853061099031553 0.21055342566987345 0.8447535426868474 0.04703875407218763 0.10893500133376921 1.5585810257209708e-07 6.807270615197337 0.45703285638785196 ELVDK(ub)NIDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELVDKNIDR 9 1 Q5BJH7-2;Q5BJH7-6;Q5BJH7-3;Q5BJH7;K7ERQ0;K7ERY2;Q5BJH7-4;Q5BJH7-5;K7EJQ6 Q5BJH7-2 YIF1B Protein YIF1B 1 8035090.0 503630.0 663860.0 6867600.0 True False 660263.8071598575 564814.6757060129 6157006.630670908 1.0 0.8554378864647729 9.325070621628402 19.332683040178335 -6.903020442300366 0.9420011047872096 0.6764494165773958 10.270625785727999 0.9880093429778956 0.43351670348012744 0.1092151754329179 0.1651567800987127 0.3431073951525057 0.9069985994932969 1.2502001817400352e-07 6.903020442300366 9.594176369150603 up ELVDK(ub)NIDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELVDKNIDR 9 1 Q5BJH7-2;Q5BJH7-6;Q5BJH7-3;Q5BJH7;K7ERQ0;K7ERY2;Q5BJH7-4;Q5BJH7-5;K7EJQ6 Q5BJH7-2 YIF1B Protein YIF1B 1 21464370.0 639170.0 1189200.0 19636000.0 True False 618879.8982139691 1664053.7615960746 14492742.532626925 1.0 2.6888153362201326 23.417697964421947 19.23929993708684 -6.923069840090131 0.8016248315315083 0.591235134147272 27.00848105510947 0.9949921385247686 0.7213267461607178 0.0963990729443374 0.09649859695081024 0.6318228949653683 1.9519279537950922 1.1937961113910964e-07 6.923069840090131 26.4172459209622 ELVDK(ub)NIDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELVDKNIDR 9 1 Q5BJH7-2;Q5BJH7-6;Q5BJH7-3;Q5BJH7;K7ERQ0;K7ERY2;Q5BJH7-4;Q5BJH7-5;K7EJQ6 Q5BJH7-2 YIF1B Protein YIF1B 1 12720190.0 503630.0 472960.0 11743600.0 True False 689835.6210889996 452063.06333043106 8970003.54703396 1.0 0.6553199769776862 13.003102873802874 19.395893101701226 -6.900481545728206 0.958251657037095 0.493385760112256 14.311808360307555 0.9868034256553421 0.6595376559338861 0.11105058644671366 0.1754417497867611 0.5157537830302056 1.3451249534631315 1.257530288877321e-07 6.900481545728206 13.8184226001953 up ELVDK(ub)NIDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELVDKNIDR 9 1 Q5BJH7-2;Q5BJH7-6;Q5BJH7-3;Q5BJH7;K7ERQ0;K7ERY2;Q5BJH7-4;Q5BJH7-5;K7EJQ6 Q5BJH7-2 YIF1B Protein YIF1B 1 10327070.0 639170.0 1266200.0 8421700.0 True False 531498.1750320665 1259378.7292789787 10182638.532458777 1.0 2.3694883415225223 19.158369700600446 19.019705212521117 -6.923087722613054 0.8014941371306505 0.6691513628498532 22.06781644292067 0.9949965301103277 0.583996841354533 0.09638884061689863 0.09644864818100969 0.5115832775028469 1.580748637920597 1.1937469566177615e-07 6.923087722613054 21.398665080070817 up ELVITDPVIK(ub)NR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELVITDPVIKNR 12 1 Q9P2R6;A0A590UK57;H7BYW9;A0A590UJ84;H0Y975 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 3885880.0 1303500.0 920880.0 1661500.0 True False 1262121.1059998262 1288592.1863257603 1226303.3060684262 1.0 1.0209734867756326 0.9716209484485042 20.267418919139548 -6.791270687944166 1.491567636576657 1.0117028009025106 0.9710798753070374 0.8053158132597715 0.008923245352946602 0.23346606584244536 1.0261283600937385 0.004708865555612751 0.01101298871373419 1.6170718316714134e-07 6.791270687944166 -0.0406229255954732 ELVITDPVIK(ub)NR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELVITDPVIKNR 12 1 Q9P2R6;A0A590UK57;H7BYW9;A0A590UJ84;H0Y975 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 4407700.0 1303500.0 1798100.0 1306100.0 True False 1083918.0048411204 1788413.2784050936 1579199.4712759168 1.0 1.6499525521464489 1.4569362850535859 20.047824194573824 -10.367105486002428 5.242041438049125 0.9997336732780815 1.5534444186000427 0.9164035510872046 0.078798561072466 0.00024538033563426746 2.96256401833174e-05 0.07633229402670574 0.025432126228218006 4.2943210911823046e-11 10.367105486002428 0.5537107453219612 ELVTVLLQHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELVTVLLQHR 10 0 Q9BR61;A0A2R8Y544 Q9BR61 ACBD6 Acyl-CoA-binding domain-containing protein 6 0 8350400.0 2972600.0 3213000.0 2164800.0 False True 3897107.386699347 2733632.9241759083 1940807.2622279087 1.0 0.7014517828032338 0.4980122613125307 21.893972255546046 -8.079083948728645 0.12817720101668076 1.4220914531855011 1.1149747050399492e-13 0.9999696179565466 0.0011363267620437003 0.09617584115459094 0.022915734124124905 0.11030555129003052 0.12440888378777343 8.335200503783887e-09 8.079083948728645 -1.4220914531853897 down ELVTVLLQHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELVTVLLQHR 10 0 Q9BR61;A0A2R8Y544 Q9BR61 ACBD6 Acyl-CoA-binding domain-containing protein 6 0 6529100.0 2785900.0 1255200.0 2488000.0 False True 2697463.129424561 1756407.9057815266 1836318.161599909 1.0 0.6511332394582958 0.6807574648820662 21.36317180953427 -10.067958504984487 5.228761925558006 1.0000044708932831 0.6659453521695803 0.9941363735271151 0.012094039387668775 6.303368994519555e-07 1.1234881846446157e-07 0.011710160031447644 0.003903334427765896 8.551484148244475e-11 10.067958504984487 -0.33405911872370286 ELVTVLLQHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELVTVLLQHR 10 0 Q9BR61;A0A2R8Y544 Q9BR61 ACBD6 Acyl-CoA-binding domain-containing protein 6 0 17972100.0 3289400.0 7348000.0 7334700.0 False True 4990260.2873519985 6036691.989813955 5884993.330086782 1.0 1.209694813938699 1.1792958665908706 22.250683636485608 -10.030345089691599 4.360835300626854 0.9999887457798751 1.1944953402985488 0.982008177489318 0.012410318398549398 1846859.9521707895 2123978.7106903633 158.627804683996 0.004248382179426647 9.325130329859064e-11 10.030345089691599 0.1945065945186737 ELVTVLLQHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELVTVLLQHR 10 0 Q9BR61;A0A2R8Y544 Q9BR61 ACBD6 Acyl-CoA-binding domain-containing protein 6 0 11651800.0 2972600.0 3003800.0 5675400.0 False True 4071650.5514944694 2871082.1837617313 4334987.408532015 1.0 0.7051396350081963 1.0646757018332258 21.957182317068938 -6.688760072603045 1.8709157142493498 0.8149272934210139 1.0634122806904818 0.36461811268359967 0.1247365825473598 0.4193206788720042 2.8447749890991947 0.05335680837570304 0.13915756240337648 2.0475755140599938e-07 6.688760072603045 0.24848498726946788 ELVTVLLQHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELVTVLLQHR 10 0 Q9BR61;A0A2R8Y544 Q9BR61 ACBD6 Acyl-CoA-binding domain-containing protein 6 0 6028400.0 2785900.0 1380900.0 1861600.0 False True 2316599.286296031 1373460.817612811 2250851.952934115 1.0 0.5928780284694004 0.9716190306407985 21.143577084968545 -10.498316022408284 8.92994432386682 1.0000072102630349 0.7822485295550995 0.30590921492247936 0.15462036666504347 2.2196462765665508e-05 1.2467992067739583e-06 0.14971548119380268 0.0499035087565165 3.174563200379106e-11 10.498316022408284 -0.21775868070793536 ELVTVLLQHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELVTVLLQHR 10 0 Q9BR61;A0A2R8Y544 Q9BR61 ACBD6 Acyl-CoA-binding domain-containing protein 6 0 15468700.0 3289400.0 6851800.0 5327500.0 False True 4258193.143767741 6470491.306783738 4357949.664766176 1.0 1.5195391773747746 1.023426960128485 22.021809958578057 -10.596654277931009 3.3379481018766057 0.9877837039856595 1.2714830685348935 0.28534056529084895 0.20253696494224543 22607822.249025602 18107662.327959653 1919208.3249489837 0.06933378136345539 2.5313122570777173e-11 10.596654277931009 0.28369936454923395 ELVVTQLGYDTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELVVTQLGYDTR 12 0 Q01813;Q01813-2;B1APP6;V9GY25 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 0 17644500.0 5851300.0 5221100.0 6572100.0 False True 7671110.964069807 4442132.231688402 5892082.1360347485 1.0 0.5790728686489612 0.7680871993160143 22.87100409963224 -10.01230454413955 4.6773169753213155 1.0000074241636647 0.6735800339664194 0.7990561939816445 0.0771647774199446 24817387.734587952 26562155.59351211 1620.762089903624 0.026415555586192154 9.720653347965086e-11 10.01230454413955 -0.3264273901972453 ELVVTQLGYDTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELVVTQLGYDTR 12 0 Q01813;Q01813-2;B1APP6;V9GY25 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 0 11672200.0 4183800.0 1655000.0 5833400.0 False True 4050987.559096337 2315850.130710986 4305457.541751167 1.0 0.5716754487460307 1.0628167771296724 21.949842223724584 -6.676156961041907 1.9150628443239306 0.728077904023393 1.0609186478455936 0.3068834676349068 0.18168621497028553 0.44708848454180794 3.1665852681709397 0.07621243597992647 0.20203562729138597 2.1078661953540745e-07 6.676156961041907 0.33284074382220064 ELVVTQLGYDTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELVVTQLGYDTR 12 0 Q01813;Q01813-2;B1APP6;V9GY25 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 0 15375600.0 5851300.0 4344400.0 5179900.0 False True 8014683.7354368605 4152450.0429903697 3956514.303389192 1.0 0.5181052902474922 0.4936581946328706 22.934214161155133 -13.935971917647063 0.4255064129896604 9.999999999429361 0.49301769532416573 0.9998699908846684 0.0026583295655482346 29.174778585838766 0.2181447130461371 244.1238330677489 0.005852370446874888 1.1588522874475084e-14 13.935971917647063 -9.506982304105195 ELVYPPDYNPEGKVTK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELVYPPDYNPEGKVTK 16 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 20407900.0 6473900.0 5504400.0 8429600.0 True False 8867475.780569226 5261197.407383333 6438702.0930615505 1.0 0.5933139867054256 0.7261031495761507 23.08009205410681 -10.914099262136823 11.16702268135657 1.0373762328008254 0.6597085681407882 0.8975010383897357 0.054210948734101025 0.02911942329654989 0.00022399663969686825 0.03029935779586205 0.01749650846910644 1.21871101908871e-11 10.914099262136823 -0.3776676646600372 ELWAVLNGWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELWAVLNGWR 10 0 C9J0K6;P30626-3;P30626-2;P30626 C9J0K6 SRI Sorcin 0 5537200.0 1463200.0 1967400.0 2106600.0 False True 1918269.369648958 1673871.5888651344 1888629.239934086 1.0 0.8725946498178468 0.9845485049264504 20.871373891854315 -10.233185773161383 5.182434397729909 1.0000075840997726 0.9285715778238158 0.35180836678789973 0.04570496995900434 4.005467680746237e-06 5.926348510269898e-07 0.044258345107156725 0.014751215624166635 5.845399887022497e-11 10.233185773161383 -0.07143600627595681 ELWAVLNGWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELWAVLNGWR 10 0 C9J0K6;P30626-3;P30626-2;P30626 C9J0K6 SRI Sorcin 0 8699900.0 3712700.0 1713700.0 3273500.0 False True 3594842.370729229 2397989.346827442 2416072.147105022 1.0 0.6670638374446999 0.6720940441722099 21.777497081031026 -9.93487177372838 5.87293557580795 1.0000001835009262 0.6695789408084147 0.9998262097359628 0.0020535732977700516 4.934247722966277e-09 8.954875746720067e-10 0.001988364906436449 0.0006627879317879291 1.1617915843810061e-10 9.93487177372838 -0.3304212426925115 ELWAVLNGWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELWAVLNGWR 10 0 C9J0K6;P30626-3;P30626-2;P30626 C9J0K6 SRI Sorcin 0 9234700.0 2509000.0 2886200.0 3839500.0 False True 3806336.4324698006 2371135.0600164747 3080621.1420873716 1.0 0.6229441622105713 0.8093402138098609 21.859971652745056 -10.152144674252918 5.017209916148183 1.0000158209474679 0.716142188009684 0.7556324301656003 0.07609586941647024 1.3467363724072821e-05 2.2758547212409894e-06 0.07368361256959893 0.02455983624683268 7.044583573412116e-11 10.152144674252918 -0.2838736329377839 ELWAVLNGWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELWAVLNGWR 10 0 C9J0K6;P30626-3;P30626-2;P30626 C9J0K6 SRI Sorcin 0 8446800.0 1463200.0 2588700.0 4394900.0 False True 2004184.5814932103 2474322.6743138675 3356915.1358067044 1.0 1.2345782405283163 1.6749530790750058 20.934583953377206 -6.96126387492396 0.4172391902148322 0.9799463392856462 1.9461220628665723 0.9998142398716426 0.0038132978897691284 0.07925268082046448 0.019485661359670756 0.005687390434810541 0.0366865074311091 1.093291886325158e-07 6.96126387492396 0.9661757235809261 ELWAVLNGWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELWAVLNGWR 10 0 C9J0K6;P30626-3;P30626-2;P30626 C9J0K6 SRI Sorcin 0 7033200.0 3712700.0 1550500.0 1770000.0 False True 3087274.5504976013 1542147.1487498458 2140098.8164446647 1.0 0.49951733269115484 0.6932000317560767 21.557902356465302 -10.313617686777048 5.263949989058995 1.0000983810660766 0.5963586822235961 0.8527447618201828 0.07907063078579037 9.131603262626176e-05 1.190702668655735e-05 0.07657835840934443 0.025519936350607727 4.857158919551854e-11 10.313617686777048 -0.4037396988424805 ELWAVLNGWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELWAVLNGWR 10 0 C9J0K6;P30626-3;P30626-2;P30626 C9J0K6 SRI Sorcin 0 12255700.0 2509000.0 4713400.0 5033300.0 False True 3247949.9597839294 4451095.146588404 4117291.046019257 1.0 1.3704321808223037 1.2676583989899772 21.631097974837505 -10.125750793560732 4.439271525142134 0.9999587632263383 1.3190452899169303 0.9277940700258746 0.041957220787271786 29280314.268313643 0.8293752703481364 12558.150921640026 0.01436307266472419 7.485989376076183e-11 10.125750793560732 0.319086526690592 ELWTILLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELWTILLGR 9 0 Q5SRE5;Q5SRE5-2;H7C4K7 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 0 3279020.0 1322300.0 892520.0 1064200.0 False True 1733548.1051714148 759359.4950157122 954086.7925272246 1.0 0.4380377404875223 0.550366493829073 20.72529644055157 -10.80078056210051 7.9634043904755325 1.0131072644180867 0.49420211715829765 0.9643290731228568 0.045858021521625006 0.010350253500008897 0.0002589306145125695 0.043064941113674066 0.014800612803606243 1.5820472053640208e-11 10.80078056210051 -0.5189051472597891 ELWTILLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELWTILLGR 9 0 Q5SRE5;Q5SRE5-2;H7C4K7 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 0 4614100.0 1322300.0 1216000.0 2075800.0 False True 1811190.0438138796 1162273.0992257365 1585538.7924429586 1.0 0.6417179153537647 0.8754127143412515 20.788506502074462 -10.144826544319198 4.999968263793301 1.0000127926207123 0.7585653148469714 0.5873080551513443 0.0954055021787983 1.360584702953206e-05 2.327250390978679e-06 0.09238087259567944 0.030791993422653877 7.164294924856311e-11 10.144826544319198 -0.24144747777374087 ELYDK(ub)GGEQAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELYDKGGEQAIK 12 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 62372500.0 13301700.0 17379900.0 31690900.0 True False 17438657.51384605 14786886.666319584 28411829.668578357 1.0 0.847937213892698 1.6292440886587605 24.055785645113907 -6.8562245279349385 1.2047062308212448 0.9181912915171111 1.664431310852651 0.9488764383095061 0.0764724364945603 0.15074500608759495 0.4178966451794761 0.04958056812858458 0.11528435513282713 1.3924367344472452e-07 6.8562245279349385 0.7462400193355399 ELYDK(ub)GGEQAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ELYDKGGEQAIK 12 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 124794900.0 16814000.0 25887900.0 82093000.0 True False 16280248.773518262 36225073.473615065 60590380.56278991 1.0 2.22509336175129 3.7217109766373646 23.956619409367228 -6.968443662672992 0.29298320115548143 0.7178113784086406 5.2754257846800074 0.9999675710663001 0.006337992621438261 0.07681099132040776 0.01082821572621066 0.025735420247367413 0.1352583807810334 1.0753660894358835e-07 6.968443662672992 4.557614406271367 ELYDK(ub)GGEQAIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ELYDKGGEQAIK 12 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 317262000.0 77048000.0 130072000.0 110142000.0 True False 116887448.9633055 106859635.34282535 88372385.42304641 1.0 0.9142096631467406 0.7560468314334515 26.800544784857962 -6.961605763988578 0.4121822625132654 1.0076082379779714 0.6567577926934948 0.9998251856818828 0.0013359617861787687 0.07913246270082869 0.019048366622553447 0.002038029632431429 0.013196231906164414 1.0924315542979569e-07 6.961605763988578 -0.3508504452844766 ELYDK(ub)GGEQAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELYDKGGEQAIK 12 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 73356000.0 13301700.0 16209300.0 43845000.0 True False 18219697.954926345 15493119.529012939 33489714.016119786 1.0 0.8503499655889641 1.838104786312588 24.1189957066368 -6.868284478665774 1.1430655432963837 0.9161729022675553 1.8941136585007092 0.9629443459265092 0.08367409597906242 0.13851393009757584 0.3393151790166406 0.05686506779052421 0.13425033166784175 1.3543020047188748e-07 6.868284478665774 0.9779407562331539 ELYDK(ub)GGEQAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ELYDKGGEQAIK 12 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 93088000.0 16814000.0 37862000.0 38412000.0 True False 13981585.9864968 37658029.890981466 46443771.60297877 1.0 2.693401873532159 3.3217813521179536 23.737024684801504 -9.561021146411779 0.285442189784826 3.655160949129693e-16 3.599973415207453 0.99883212862372 0.03350912550471242 0.9456972323142753 0.11643357535367044 1.1026204032708735 0.23442482893506328 2.7477603575119676e-10 9.561021146411779 3.5999734152074527 ELYDK(ub)GGEQAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ELYDKGGEQAIK 12 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 279683000.0 77048000.0 103263000.0 99372000.0 True False 99740154.8431377 97516323.27452774 81287315.64282396 1.0 0.9777037485844353 0.8149908707347138 26.57167110695041 -6.93184683049199 0.7314714330401945 1.0023126722251596 0.7799592135269081 0.9968889569070436 0.0045994998673239244 0.09169016793987729 0.07306443602187047 0.004237373439512932 0.01457607334374368 1.1699119296224007e-07 6.93184683049199 -0.22235345869825152 ELYLFDVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ELYLFDVLR 9 0 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 4381480.0 791080.0 2000200.0 1590200.0 False True 1037113.5408296165 1701777.9567185333 1425661.3582755057 1.0 1.6408791224124148 1.3746434716637475 19.98414241509056 -10.017462998930807 4.384552248610933 0.9999764755178838 1.5077612969291618 0.8290545306018766 0.10869024957770203 75632744.08721383 164689130.61687922 28261.05403367226 0.039776581012300125 9.605876551535564e-11 10.017462998930807 0.507784821411278 ELYLFDVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ELYLFDVLR 9 0 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 8328380.0 791080.0 2601300.0 4936000.0 False True 1083563.654133164 2486365.9646512363 3770218.4601110104 1.0 2.2946191994971397 3.479461908610374 20.04735247661345 -6.972184009477136 0.19922905485765444 0.2876993730837692 5.519067975647498 0.9999947818223466 0.002313032482496256 0.07560017327814338 0.0064267318599386305 0.038713147980844326 0.12603194088620404 1.0661443028664671e-07 6.972184009477136 5.2313686025637285 EMAAMCLGLAHSLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMAAMCLGLAHSLSR 15 0 Q9Y2X3;H7BZ72 Q9Y2X3 NOP58 Nucleolar protein 58 0 4648500.0 1418000.0 1440100.0 1790400.0 False True 1859011.7319315313 1225242.6934658326 1605146.5827295103 1.0 0.6590828193390654 0.8634408030667711 20.826104444232474 -10.290376486691349 5.594895258220219 1.0000255654042889 0.761261811202914 0.6453520845793448 0.08342879749949272 2.6607756311381308e-05 3.374829745339141e-06 0.08078822633313618 0.026926528609135022 5.124169808833194e-11 10.290376486691349 -0.23876375420137486 EMAAMCLGLAHSLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EMAAMCLGLAHSLSR 15 0 Q9Y2X3;H7BZ72 Q9Y2X3 NOP58 Nucleolar protein 58 0 4899300.0 1418000.0 1919500.0 1561800.0 False True 1942272.9200091348 1834690.1430623366 1192935.0062806671 1.0 0.9446098558866319 0.6141953553443233 20.889314505755365 -6.93595811131916 0.696150317987401 1.004092180337432 0.5347766053608084 0.9975850949903855 0.008369920265443361 0.08965997948655602 0.06337515676896482 0.007916654593270619 0.028980453887774735 1.1588891282310184e-07 6.93595811131916 -0.4693155749766237 EMDEAATAEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMDEAATAEER 11 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 5398040.0 548340.0 3153400.0 1696300.0 False True 718879.050132113 2682925.0118569266 1520783.1480585735 1.0 3.732095143632115 2.115492373548915 19.455389535153017 -9.77629993758536 6.51813386663049 0.9999999806126081 2.9237937585910925 0.6537641781264382 0.6599753172476863 1.9479999212875596e-07 3.6521633158793094e-08 0.6390183626731977 0.21300611771704783 1.673786506550235e-10 9.77629993758536 1.9237937779784844 EMDEAATAEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EMDEAATAEER 11 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 3683940.0 548340.0 1419900.0 1715700.0 False True 751076.1163313183 1357164.123018602 1310486.9959506607 1.0 1.806959499188659 1.7448124996329566 19.51859959667591 -10.095559130204522 4.313532967127461 0.9999031140644298 1.7758859994950407 0.9952112619747853 0.025371406617076167 17792477.243572544 37714729.18412515 24749.914633801847 0.009284983409766624 8.024922922408339e-11 10.095559130204522 0.7759828854306109 EMDEEDKAFK(ub)QK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EMDEEDKAFKQK 12 2 Q9Y2S6 Q9Y2S6 TMA7 Translation machinery-associated protein 7 1 6647400.0 2214700.0 2763400.0 1669300.0 True False 3359861.816257816 2270249.6794572514 1339362.1233198203 1.0 0.6756973362630239 0.398636073911989 21.67997046866777 -7.3507934534616295 0.20994364024604523 1.1711274660449411 5.415210310659809e-13 0.9999660641294712 0.0014316403884211278 0.1137545246919099 0.014673983296563681 0.021278107673257732 0.051829759996273685 4.458682488983053e-08 7.3507934534616295 -1.1711274660443995 down EMDQTMAANAQK(ub)NK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EMDQTMAANAQKNK 14 1 P30085;P30085-3;Q5T0D2 P30085 CMPK1 UMP-CMP kinase 1 4591000.0 1261100.0 1689700.0 1640200.0 True False 1221067.0707912394 2364406.021669097 1210582.4150547313 1.0 1.9363441028157324 0.9914135300285232 20.2197110162018 -6.648279007373121 2.0144931005958173 1.6084323462902312 0.9953748982792899 0.18706028991767887 0.399814643263471 0.5128443958367332 3.9871647250797895 0.16106167230224497 0.4428610453616792 2.2476101912254616e-07 6.648279007373121 -0.6130574480109413 EMDQTMAANAQK(ub)NK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 EMDQTMAANAQKNK 14 1 P30085;P30085-3;Q5T0D2 P30085 CMPK1 UMP-CMP kinase 1 6472510.0 1801460.0 1150150.0 3520900.0 True False 2332025.482085435 1086143.1414368937 2880132.3274847902 1.0 0.465750974755902 1.235034672481025 21.15315212230402 -6.719962266337486 1.759856201761846 0.6749499955953491 1.233800212095683 0.5121777220969224 0.22481476700583766 0.35537999002156667 2.151085591343237 0.10144206923166993 0.25462986456544606 1.9056262810506614e-07 6.719962266337486 0.558850216500334 EMDYETEVEMEK(ub)GFNPAQPLNIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EMDYETEVEMEKGFNPAQPLNIR 23 1 Q12769;G3V198;E9PR16 Q12769 NUP160 Nuclear pore complex protein Nup160 1 22134600.0 7318100.0 5309300.0 9507200.0 True False 7085790.92122541 7429331.177633734 7016979.110113609 1.0 1.048482979561146 0.9902887607217317 22.756497466143458 -6.685567511788652 1.882183128908883 1.0305195819914523 0.9904994669134861 0.3499262037441203 0.020523397796896405 0.42616878218201953 2.9235444497207026 0.00873466339594921 0.022873449919539227 2.0626829949362801e-07 6.685567511788652 -0.04002011507796621 EMDYETEVEMEK(ub)GFNPAQPLNIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EMDYETEVEMEKGFNPAQPLNIR 23 1 Q12769;G3V198;E9PR16 Q12769 NUP160 Nuclear pore complex protein Nup160 1 65492000.0 12806000.0 25989000.0 26697000.0 True False 19427638.24400489 21351059.89701618 21420326.24828923 1.0 1.0990043992405938 1.1025697503349001 24.211607191961328 -13.038444816528692 0.4854285667381176 8.463684204129809e-05 1.1024374665813634 0.9999174386775813 0.00043186877948158623 16.62445441199077 0.24296267734295854 17.4499649230562 0.0007468461546648644 9.152825519392851e-14 13.038444816528692 1.1023528297393221 EMDYETEVEMEK(ub)GFNPAQPLNIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EMDYETEVEMEKGFNPAQPLNIR 23 1 Q12769;G3V198;E9PR16 Q12769 NUP160 Nuclear pore complex protein Nup160 1 20705600.0 7318100.0 6557600.0 6829900.0 True False 6085324.396799231 6522272.907218317 8258000.512110395 1.0 1.0718036511987614 1.3570353811300433 22.536902741577734 -6.945034389512405 0.6109399541940762 0.9968491640599276 1.446867671731284 0.9987516581194567 0.0054480255691430205 0.08554323163478385 0.04470284102551608 0.005532879044147938 0.024059413250974014 1.1349209436504405e-07 6.945034389512405 0.4500185076713564 EMDYETEVEMEK(ub)GFNPAQPLNIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EMDYETEVEMEKGFNPAQPLNIR 23 1 Q12769;G3V198;E9PR16 Q12769 NUP160 Nuclear pore complex protein Nup160 1 47334000.0 12806000.0 15101000.0 19427000.0 True False 16577619.443998806 14260616.07515415 15891485.337853123 1.0 0.8602330463265988 0.9586108181296158 23.982733514053777 -10.145850263175511 4.4713340678641575 1.0000113860322846 0.9094219322282163 0.5305809063261226 0.04016255719052069 56167046.74154333 0.04871568773252519 7942.487529091803 0.01374871158265642 7.147427138631479e-11 10.145850263175511 -0.09058945380406824 EMEAELEDER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMEAELEDER 10 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 8755300.0 1168000.0 3780800.0 3806500.0 False True 1531259.31092809 3216719.377442971 3412639.8945262986 1.0 2.1007019219320404 2.2286492367239297 20.546287185872977 -10.775389007153846 0.4096217087468484 1.0134532779183518e-09 2.2373454441509844 0.9994628078049026 0.012782628009685899 2.3912332600508597 0.19781713303098153 2.383351646078685 0.03179665949709935 1.677300949572758e-11 10.775389007153846 2.237345443137531 EMEAELEDER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EMEAELEDER 10 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 7219300.0 1168000.0 2649700.0 3401600.0 False True 1599841.1640131683 2532627.4926138413 2598212.1381510594 1.0 1.5830493361358435 1.6240438092200968 20.60949724739587 -11.464167427159026 0.4404036559523302 9.515621530911667e-14 1.6247245043226386 0.9997504140635349 0.004502609533157389 3.940057528693602 0.21821908680187285 3.7775150115475813 0.00945185546665826 3.434255265880693e-12 11.464167427159026 1.6247245043225433 EMEAELEDERK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMEAELEDERK 11 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 5156360.0 372860.0 2446900.0 2336600.0 False True 488823.0707813763 2081832.0579414961 2094831.0462498714 1.0 4.25886620820437 4.285458628008935 18.89895285148466 -10.437516544873029 0.9168388137875488 4.414341233081511e-18 4.278829890224278 0.999989905758553 0.0049009006010741025 1.889280765696436 0.5179013426051544 4.658704686518144 0.0036075149505715894 3.6516021585430484e-11 10.437516544873029 4.278829890224278 EMEAELEDERK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EMEAELEDERK 11 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 4192260.0 372860.0 1904300.0 1915100.0 False True 510716.4181626282 1820161.7293220113 1462792.8227225677 1.0 3.563938155484194 2.8641977635752616 18.96216291300755 -10.306607724980042 5.517011932193116 0.9996690689695484 3.214067959529776 0.9303084352168076 0.2856678187655052 0.0011629517837643284 0.00014616110721475242 0.2766330562266183 0.09219889205215867 4.936194627627362e-11 10.306607724980042 2.2143988905602274 EMEEEAEK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EMEEEAEKLK 10 1 Q92843-2;Q86U42-2;Q86U42 Q92843-2 PABPN1 Polyadenylate-binding protein 2 1 3372980.0 1001000.0 914080.0 1457900.0 True False 969223.8029196984 1279076.9108642288 1076032.2539375026 1.0 1.3196920123207108 1.1101999875529815 19.886470310439986 -10.251262947049305 3.930655531193448 0.9997646944217952 1.2149459997884442 0.5839680910185128 0.08552476128726116 60424216.478438035 56.620663120536285 134021.44576345794 0.02927740056631423 5.6070838788524335e-11 10.251262947049305 0.21518130536664903 EMEEQMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EMEEQMR 7 0 P23246;P23246-2;H0Y9K7;H0Y9U2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 2509010.0 754730.0 363980.0 1390300.0 False True 730771.5092683157 509319.11213062494 1026138.7218940314 1.0 0.6969608224608814 1.4041854517856776 19.479060862865055 -6.7902653125808445 1.4952127923324081 0.8306881931315375 1.411767781714171 0.8021900554254267 0.12884907953140856 0.23496273865629266 1.0377279640892383 0.06782721507162282 0.15877358440300746 1.6208196283680167e-07 6.7902653125808445 0.5810795885826334 EMFEDTVEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EMFEDTVEER 10 0 Q16576;E9PC52 Q16576 RBBP7 Histone-binding protein RBBP7 0 4627990.0 2568200.0 875690.0 1184100.0 False True 2135572.0905508003 870972.4841591445 1431689.8353401853 1.0 0.40784035716373584 0.6704010797270384 21.026191169212293 -10.393720456351506 5.986582724286059 1.0001081544873536 0.5391207184454015 0.8042370544847607 0.10718996612942577 0.00015476776834192675 1.5673701762516797e-05 0.1038103620122578 0.034595412808316794 4.039052922600262e-11 10.393720456351506 -0.460987436041952 EMFGLYGQTTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMFGLYGQTTGK 12 0 Q9Y6B6;D6RD69;D6R9R5;Q9H029 Q9Y6B6 SAR1B;DKFZp434B2017 GTP-binding protein SAR1b 0 13757000.0 4261400.0 3159300.0 6336300.0 False True 5586736.667456306 2687944.7548549497 5680680.458081435 1.0 0.48112966743406516 1.0168155036145463 22.41357438934615 -10.897128522488554 12.088587327239887 1.0143268367939942 0.7489725855243058 0.22648097055286087 0.21869282684638644 0.07702612214517573 0.0006554756836505383 0.19315039725151734 0.07058280635925641 1.2672767801163893e-11 10.897128522488554 -0.26535425126968837 EMFGLYGQTTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EMFGLYGQTTGK 12 0 Q9Y6B6;D6RD69;D6R9R5;Q9H029 Q9Y6B6 SAR1B;DKFZp434B2017 GTP-binding protein SAR1b 0 7326800.0 2243500.0 1031400.0 4051900.0 False True 2172281.320529812 1443243.3986799465 2990585.8356055734 1.0 0.6643906500691836 1.3767028272729334 21.050779520280336 -6.778588969098976 1.5414330148284987 0.8096221813177729 1.3820916307997866 0.7623495837305296 0.14184198495717934 0.25276986198383605 1.186185731645268 0.07248490198070519 0.1712321682880626 1.664987705260376e-07 6.778588969098976 0.5724694494820137 EMFGLYGQTTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EMFGLYGQTTGK 12 0 Q9Y6B6;D6RD69;D6R9R5;Q9H029 Q9Y6B6 SAR1B;DKFZp434B2017 GTP-binding protein SAR1b 0 9022900.0 4261400.0 1640500.0 3121000.0 False True 5836954.740004894 1568017.2855919572 2383884.079012654 1.0 0.2686361905198947 0.4084122946292804 22.47678445086904 -9.907186757990074 6.726427218551274 1.0000000294974996 0.3385242426014845 0.9675963821166425 0.05706335555039573 2.522153079673664e-08 4.161573470351707e-09 0.05525135890124736 0.01841711881044368 1.2382639861106254e-10 9.907186757990074 -0.661475786896015 EMFGLYGQTTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EMFGLYGQTTGK 12 0 Q9Y6B6;D6RD69;D6R9R5;Q9H029 Q9Y6B6 SAR1B;DKFZp434B2017 GTP-binding protein SAR1b 0 5420850.0 2243500.0 2186100.0 991250.0 False True 1865569.653901844 2174323.0453931266 1198515.7919778365 1.0 1.1655008650282899 0.6424395837867203 20.831184795714613 -6.821629691904701 1.3648130529662588 1.0890619000703066 0.6306178609225422 0.8880778323017874 0.07302657728920332 0.1913812995626781 0.7000331479886758 0.04204182152444009 0.09685983736272341 1.5078922464937006e-07 6.821629691904701 -0.4584440391477643 EMGFTNMTEIQHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMGFTNMTEIQHK 13 0 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 4157100.0 0.0 2641500.0 1515600.0 False True 0.0 2247398.496486354 1358780.2506617769 0.0 EMGGHHIVALCVLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 EMGGHHIVALCVLK 14 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 130537000.0 40553000.0 40347000.0 49637000.0 False True 53165375.715810575 34327384.871374175 44501039.39172515 1.0 0.6456718194726447 0.8370304694092704 25.663983651565196 -10.179875304563534 4.987841892753656 1.0000209922076935 0.7413511444405494 0.708957438648196 0.07812184170351535 1.823817525233895e-05 2.9987584409050018e-06 0.0756472833903928 0.025213715990861547 6.608831747708118e-11 10.179875304563534 -0.2586698477671441 EMGGHHIVALCVLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 EMGGHHIVALCVLK 14 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 169810000.0 30927000.0 74369000.0 64514000.0 False True 46918520.06655779 61097270.90235088 51762779.6225093 1.0 1.3021994473755645 1.1032483451967268 25.48365417190211 -10.256795332835589 3.781138256747284 0.9996887864835439 1.2027238962243654 0.5806041012160719 0.0812214476076082 9831993.328188535 6667673.688521082 23285.759055408067 0.027804262411552205 5.536109444153626e-11 10.256795332835589 0.2030351097408215 EMGGHHIVALCVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EMGGHHIVALCVLK 14 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 125776000.0 40553000.0 32569000.0 52654000.0 False True 55546540.003618084 31129993.888719555 40218209.64316963 1.0 0.5604308366766295 0.7240452715965742 25.727193713088088 -10.218494895314677 4.9299384375491835 1.00005021359852 0.642238054136115 0.8644077508847419 0.066795313352967 3.686992344221217e-05 5.844642031175467e-06 0.06468333973223298 0.0215580946848212 6.046514583595016e-11 10.218494895314677 -0.3578121594624051 EMGGHHIVALCVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 EMGGHHIVALCVLK 14 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 106713000.0 30927000.0 59124000.0 16662000.0 False True 40035611.162310705 55833697.42582698 13629686.96655731 1.0 1.3946008517134492 0.3404390883731087 25.25478049399456 -6.80531462164037 1.4340561468174666 1.2162756945832045 0.32389511623742673 0.8472581178522827 0.16995580029859028 0.21326140058992854 0.865206792755856 0.09321016786027242 0.21611566771203 1.5656164591376456e-07 6.80531462164037 -0.8923805783457778 down EMGLSLQWLYSAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EMGLSLQWLYSAR 13 0 P02786;G3V0E5;H7C3V5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 0 11031900.0 2978900.0 0.0 8053000.0 False True 4519209.086761381 0.0 6461321.02024472 1.0 0.0 1.4297459790414617 22.107638875936008 -6.718668649143187 1.7638704002523857 0.3907415945887676 1.4273817695290665 0.5062549296009481 0.42087624515277383 0.3579510928919774 2.175703913938688 0.18950199901078607 0.47650979378177144 1.9113109629928138e-07 6.718668649143187 1.036640174940299 EMGVDVHFPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMGVDVHFPK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 10494300.0 2195400.0 4073700.0 4225200.0 False True 2878190.660283844 3465919.8391582305 3788016.8349803025 1.0 1.2042009193429963 1.3161104603844183 21.45673073316584 -13.18086416132785 0.07822380432092199 9.798340915709526e-19 1.6754759762705498 0.9999097032033942 0.001243593943505542 9.307924630735872 0.07077708979267211 1.7719872077551218 0.30486612449517647 6.593801039695228e-14 13.18086416132785 1.6754759762705498 EMGVDVHFPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EMGVDVHFPK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5628400.0 2019200.0 1382800.0 2226400.0 False True 1955101.6012542008 1934959.2512067389 1643239.049431686 1.0 0.989697543066539 0.8404878029753264 20.89881215169918 -6.9208603030398725 0.8183299542411735 1.003191370620464 0.8159445022414513 0.9944162586066094 0.00544650502748265 0.09766866206657017 0.10301408342260396 0.004714192616885158 0.014239301049633517 1.199885201120111e-07 6.9208603030398725 -0.18724686837901272 EMGVDVHFPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EMGVDVHFPK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9493000.0 2195400.0 4220100.0 3077500.0 False True 3007098.7084542043 4033642.0279955016 2350657.883102033 1.0 1.3413733365836171 0.781702933958688 21.519940794688733 -6.741614634079675 1.6806770259719233 1.2027344533363193 0.7812512033269277 0.612205646097788 0.1434266772512333 0.314907568528665 1.7471486485545578 0.06749299977273282 0.16533601559172473 1.8129480765019366e-07 6.741614634079675 -0.4214832500093917 EMGVDVHFPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EMGVDVHFPK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 4700500.0 2019200.0 1607600.0 1073700.0 False True 1679054.2657270362 1598939.5397163848 1298205.7057721105 1.0 0.9522858029987724 0.7731767413782681 20.679217427133455 -6.9463357903254925 0.5977228900076305 1.0020279290184357 0.714301791220864 0.998881425988444 0.0032656374712508275 0.08499140304032203 0.04231554362197248 0.003359227841523122 0.01504079654079902 1.1315251457536875e-07 6.9463357903254925 -0.2877261377975717 EMIK(ub)SGMNVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMIKSGMNVAR 11 1 P14618;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 6603720.0 1638010.0 2963810.0 2001900.0 True False 2147446.972511402 2521621.100840893 1794762.5915807663 1.0 1.1742413820313808 0.8357657323113421 21.034191076269114 -6.766830483133155 1.5870534717828693 1.1003468388882038 0.8341066928271039 0.7181118429204545 0.07337590657107514 0.27158954968907384 1.3495952040884152 0.036457075646759894 0.08702130527184875 1.7106829105381116e-07 6.766830483133155 -0.2662401460610999 EMIK(ub)SGMNVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EMIKSGMNVAR 11 1 P14618;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 11058640.0 3588000.0 3201840.0 4268800.0 True False 3474100.9039719068 4480351.40937502 3150673.218745048 1.0 1.2896434309817186 0.9069031976425651 21.728208226523254 -6.704284869761249 1.8153226404832699 1.1790914273850281 0.9079345369389984 0.438085593928746 0.12216831444294664 0.38665949176762027 2.480012779646189 0.05362691235654915 0.13720309560630176 1.975673298048302e-07 6.704284869761249 -0.27115689044602975 EMIK(ub)SGMNVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EMIKSGMNVAR 11 1 P14618;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 51616400.0 8678600.0 12143500.0 30794300.0 True False 13166070.690646628 9976397.547401445 24707793.10737881 1.0 0.7577353776847656 1.876626192272505 23.65032151315163 -6.850018922365105 1.2349697303093226 0.8707126144215815 1.9213772969207294 0.9403319543970292 0.11740470187563878 0.1574415357779771 0.46206154925665266 0.07438810867077408 0.17214369927205664 1.4124760012000784e-07 6.850018922365105 1.050664682499148 EMIK(ub)SGMNVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EMIKSGMNVAR 11 1 P14618;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 7860800.0 1638010.0 3011430.0 3211360.0 True False 2243626.562555827 2878375.065132692 2452902.9080352704 1.0 1.2829118326419666 1.093275926115372 21.097401137792005 -10.234809298875778 3.637305527010008 0.9996997195233064 1.1880938793333466 0.5674249165945431 0.07741853541815763 55040985.62932291 155258900.27968317 227160.9886160002 0.028332264350878805 5.823588786606465e-11 10.234809298875778 0.18839415981004026 EMIK(ub)SGMNVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EMIKSGMNVAR 11 1 P14618;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 11513200.0 3588000.0 5332500.0 2592700.0 True False 2983580.975350935 5303772.764081623 3134821.5827096496 1.0 1.7776533661727691 1.050690967869885 21.50861350195753 -10.260828837176163 4.274501227579332 0.9997215550775886 1.4141721670309249 0.3020607435592607 0.2967811564145799 209874924.61434978 289.18132287197324 592442.4120566022 0.101596083745012 5.4849309276217487e-11 10.260828837176163 0.4144506119533362 EMIK(ub)SGMNVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EMIKSGMNVAR 11 1 P14618;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 38508900.0 8678600.0 10291900.0 19538400.0 True False 11234618.780781502 9719146.717692796 15982611.680913653 1.0 0.8651069437548564 1.4226216298726846 23.42144783524408 -6.842787959520959 1.2693934687615351 0.9282469794519118 1.4419937767796969 0.9291455106331235 0.0632171816964423 0.16556307993975578 0.5170179075679912 0.03903177044158313 0.08999979309401075 1.4361904696269187e-07 6.842787959520959 0.513746797327785 EMKPACIK(ub)ALTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EMKPACIKALTR 12 2 H7BXZ6;Q8IXI2-6;Q8IXI2-4;Q8IXI2;Q8IXI2-5;Q8IXI2-2;Q8IXI2-7;Q8IXI2-3 H7BXZ6 RHOT1 Mitochondrial Rho GTPase;Mitochondrial Rho GTPase 1 1 5865400.0 2402700.0 1775900.0 1686800.0 True False 3291043.12052606 1697434.8658840319 1288412.580736479 1.0 0.515774118940351 0.391490640976631 21.650113498661415 -13.999999999999975 0.1909512211799725 3.6043286361685403 0.30317679361648225 0.9994889125993601 0.005934630212565198 12.366367544056718 0.13857612630059177 11.986954418223101 0.08482937202092088 1.0000000000000573e-14 13.999999999999975 -3.301151842552058 EMLELAK(ub)NYNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMLELAKNYNK 11 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 7905100.0 1435700.0 1383400.0 5086000.0 True False 1882216.6033385755 1177002.1124509636 4559749.50835695 1.0 0.6253276643948735 2.422542389791435 20.84400123064305 -6.852313960267397 1.2239900542156472 0.7996083279075586 2.497610314891875 0.9435889436635481 0.1838720881082467 0.15493206978414553 0.4455167458135534 0.11748039821548192 0.27226959485794283 1.4050314312495715e-07 6.852313960267397 1.6980019869843166 up EMLELAK(ub)NYNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EMLELAKNYNK 11 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 15139700.0 1142900.0 2138800.0 11858000.0 True False 1106619.2650918318 2992833.9936946514 8752034.06762528 1.0 2.7044839070701463 7.90880327471888 20.07772751425814 -6.951053949295424 0.5471503763291925 0.9267799491610345 9.929806744710957 0.9992814206139334 0.07877482687855165 0.08306526563935474 0.0342320468127158 0.08581683512421465 0.43151533313974216 1.1192988323470748e-07 6.951053949295424 9.003026795549923 EMLELAK(ub)NYNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EMLELAKNYNK 11 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 115293200.0 3464200.0 28519000.0 83310000.0 True False 5255444.66694376 23429561.630035948 66843741.98392982 1.0 4.458150188014657 12.71895076821387 22.32538140613849 -6.956429706477163 0.4831357440837937 0.8074520177620299 16.715891202763878 0.9996139879204944 0.09659223209754855 0.0810021286403704 0.026038385713104583 0.11722586265825298 0.6813821258542606 1.105529392371954e-07 6.956429706477163 15.908439185001848 EMLELAK(ub)NYNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EMLELAKNYNK 11 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 11879900.0 1435700.0 1547500.0 8896700.0 True False 1966517.0883336498 1479126.3331018304 6795482.693288012 1.0 0.7521553419885024 3.4555930043029734 20.907211292165943 -6.884485513661908 1.0544164135657927 0.8349656054294781 3.6644978276471356 0.9771290801796852 0.18453212129025 0.1237331545634456 0.24887882763450042 0.13421683374116194 0.32861882512842905 1.3047114879045746e-07 6.884485513661908 2.8295322222176575 up EMLELAK(ub)NYNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EMLELAKNYNK 11 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 12601800.0 1142900.0 2468900.0 8990000.0 True False 950371.9890547892 2455599.5456617177 10869767.434936455 1.0 2.583829883395429 11.4373819516158 19.858132789692416 -6.937351256574902 0.6837622691503438 0.894607098826301 13.64967198000497 0.9977959705184257 0.21561209586944816 0.0889960469694345 0.06027010693536573 0.20588730657683532 0.7713201991863483 1.1551775587817983e-07 6.937351256574902 12.755064881178669 EMLELAK(ub)NYNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EMLELAKNYNK 11 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 102809200.0 3464200.0 20617000.0 78728000.0 True False 4484475.189590872 19469645.826200455 64400311.81749631 1.0 4.341566181789203 14.360724297679006 22.09650772823094 -6.9514631366156285 0.5425437273792553 0.8549100852062634 18.312086193626453 0.9993111551022951 0.14899863917703154 0.08290350053452245 0.03357172391301505 0.16331507088343103 0.8300724341304964 1.1182447383763193e-07 6.9514631366156285 17.45717610842019 EMLK(ub)LLDFGSLSNLQVTQPTVGMNFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EMLKLLDFGSLSNLQVTQPTVGMNFK 26 1 H3BNC9;P08708 H3BNC9 RPS17 40S ribosomal protein S17 1 86377700.0 66553000.0 9966700.0 9858000.0 True False 64440311.44427045 13946455.285653893 7275894.066339181 1.0 0.2164243929471869 0.11290904564655234 25.941460130913043 -13.999999999999998 0.2852999324150634 7.576463910618578 0.08334069569580392 0.999616958149911 0.00775109715917374 15.692323060232905 0.16929091619269437 60.4035993280778 0.0399437430360157 1.0000000000000041e-14 13.999999999999998 -7.4931232149227744 EMLK(ub)LLDFGSLSNLQVTQPTVGMNFK ddPTM_RPMI8226_Bortezomib_8h_R1 3 EMLKLLDFGSLSNLQVTQPTVGMNFK 26 1 H3BNC9;P08708 H3BNC9 RPS17 40S ribosomal protein S17 1 2303613000.0 1473557000.0 625771000.0 204285000.0 True False 2235493700.4467554 514097275.87886095 163907980.20870358 1.0 0.22997035320480683 0.07332070771478674 31.057946334401805 -13.974159105809731 0.2282060865574977 5.771553800558562 9.991666724500709e-21 0.9994784538855868 0.009249120854356647 13.391546631797086 0.15473769875839036 28.915807768126097 0.08201820253977068 1.061306671317225e-14 13.974159105809731 -5.771553800558562 EMLK(ub)LLDFGSLSNLQVTQPTVGMNFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EMLKLLDFGSLSNLQVTQPTVGMNFK 26 1 H3BNC9;P08708 H3BNC9 RPS17 40S ribosomal protein S17 1 89427200.0 45965000.0 37262100.0 6200100.0 True False 38221934.094761826 37061361.67135222 7496512.243976587 1.0 0.9696359577060583 0.1961311592812347 25.187897447192608 -6.915180520387244 0.8597178199602111 1.0202079402316382 0.08425023599523414 0.9927336288662233 0.03171015510955199 0.10109195719689038 0.1209262809409915 0.02664554999982779 0.07648138480371783 1.2156805815020927e-07 6.915180520387244 -0.935957704236404 down EMLK(ub)LLDFGSLSNLQVTQPTVGMNFK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 EMLKLLDFGSLSNLQVTQPTVGMNFK 26 1 H3BNC9;P08708 H3BNC9 RPS17 40S ribosomal protein S17 1 1765549600.0 1246196000.0 403051600.0 116302000.0 True False 1613225288.1956527 380621424.14916927 95136229.35929352 1.0 0.23593817114960036 0.058972686614465815 30.587300780059966 -11.163674097789842 0.2771243268009718 2.1097338603318536 2.6686942056738075e-18 0.9991987260687225 0.011558657863721341 3.3348314363214264 0.1515918193999637 2.375313900849127 0.07047538551170747 6.860028219190164e-12 11.163674097789842 -2.1097338603318536 EMLNLYIENEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMLNLYIENEGK 12 0 P34932;A0A087WYC1 P34932 HSPA4 Heat shock 70 kDa protein 4 0 11761300.0 3154500.0 4473000.0 4133800.0 False True 4135580.0482214545 3805645.835617435 3706074.030209592 1.0 0.9202205715384688 0.8961437058396257 21.979658262445895 -13.999999999999995 0.16785832129166872 1.4001242745939901 0.8744135795624465 0.9995179127200016 0.0009745305671559138 12.071486417683687 0.12969642992551741 1.572484718777966 0.020019173477404516 1.0000000000000123e-14 13.999999999999995 -0.5257106950315437 EMLNLYIENEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EMLNLYIENEGK 12 0 P34932;A0A087WYC1 P34932 HSPA4 Heat shock 70 kDa protein 4 0 11970100.0 3154500.0 4092500.0 4723100.0 False True 4320803.897157138 3911679.817912272 3607601.055297875 1.0 0.9053129720804852 0.8349374656117781 22.042868323968786 -6.974384260924581 0.11153724637807119 1.1443494426846401 0.5941030772875986 0.9999995884546257 4.2999803506420836e-05 0.07490393483185133 0.003300335546272503 0.005483650816219515 0.010669625904196253 1.0607565913520939e-07 6.974384260924581 -0.5502463653970415 EMLPHVGVSDFCETK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 EMLPHVGVSDFCETKK 16 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 50610100.0 4986100.0 13626000.0 31998000.0 True False 7564278.232737208 11194333.83957608 25673581.274778362 1.0 1.4798945114324942 3.394055650103728 22.850770999455815 -6.944939518091715 0.6118857718592124 0.9788815130436724 3.9950754258360544 0.998741918669599 0.03668190086945024 0.08558367978240473 0.044878448224142775 0.03722004189325059 0.16151479633266527 1.1351688936660152e-07 6.944939518091715 3.016193912792382 up EMLPHVGVSDFCETK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EMLPHVGVSDFCETKK 16 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 5253700.0 1759500.0 1068000.0 2426200.0 True False 2410034.6986996317 1020812.2285962865 1853181.5291574837 1.0 0.4235674403970533 0.7689439202503574 21.200622487265516 -10.36263613525415 6.084308132164117 1.0000534796159495 0.5962556803237284 0.6456507114727399 0.1409993574665389 0.0001023000839589983 1.0716330642184334e-05 0.13654004811830692 0.045507346941154214 4.338742388029961e-11 10.36263613525415 -0.40379779929222104 EMLPSYHK(ub)WR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMLPSYHKWR 10 1 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 5999700.0 1234200.0 1504300.0 3261200.0 True False 1618048.1520097998 1279864.3037154742 2923762.3076393427 1.0 0.7909927168272076 1.8069686640707803 20.625823111351686 -6.853071880412124 1.2200705977437798 0.8880940857929743 1.8500788955412428 0.9446688397181472 0.10304361045257565 0.15411166616004165 0.43989679761931083 0.06602901697804173 0.15313578582507012 1.4025815430051034e-07 6.853071880412124 0.9619848097482685 EMLPSYHK(ub)WR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EMLPSYHKWR 10 1 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 19759300.0 3935700.0 7388900.0 8434700.0 True False 5970744.638210992 6070293.065260798 6767577.847939667 1.0 1.0166726988142694 1.1334562534510653 22.50947943697204 -6.932654109194039 0.7246686739442937 0.9983872144501593 1.1591370516057427 0.9970347657875291 0.0032331191652731567 0.09128272327187191 0.0710975161196335 0.0029934931959995133 0.010416952905936739 1.1677392845931461e-07 6.932654109194039 0.16074983715558333 EMLPSYHK(ub)WR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EMLPSYHKWR 10 1 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 13212700.0 3935700.0 3655400.0 5621600.0 True False 5094841.234245356 3451973.7766451556 4598526.482487005 1.0 0.6775429533392436 0.9025848443672132 22.28060575906449 -10.12699832914271 5.350310330706361 1.0000044797860093 0.7900638988531266 0.537110465419341 0.09187296729528073 4.9094409345399306e-06 8.012592764792773e-07 0.08895751600739409 0.0296518726917218 7.464516302212472e-11 10.12699832914271 -0.2099405809328827 EMLQQSK(ub)ILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMLQQSKILK 10 1 P08238;Q58FF7;P07900;P07900-2 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1 Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha 1 100245200.0 49355000.0 41261000.0 9629200.0 True False 64704882.95449986 35105019.63411832 8632862.753808638 1.0 0.5425405012911311 0.13341903052168755 25.947371253530157 -7.875870154116852 0.4008560141582773 1.0538753855301821 1.108255031304929e-25 0.9977521132236633 0.016782080839721897 0.10767647237981334 0.07804266265171865 0.03842464423858817 0.08053196118081955 1.330852258300194e-08 7.875870154116852 -1.0538753855301821 down EMLQQSK(ub)ILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EMLQQSKILK 10 1 P08238;Q58FF7;P07900;P07900-2 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1 Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha 1 117367000.0 67700000.0 28633000.0 21034000.0 True False 65550900.55710636 40066306.21912242 15524564.393525893 1.0 0.6112243444194579 0.2368322061418709 25.96611226495371 -7.605984693673932 0.32625494444328906 1.0769892775045558 1.5862507119612143e-12 0.9994232838235033 0.007482574620181616 0.1249076664468848 0.04156410893161292 0.026881542266896017 0.07200674975150416 2.4775093737278777e-08 7.605984693673932 -1.0769892775029695 down EMLQQSK(ub)ILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EMLQQSKILK 10 1 P08238;Q58FF7;P07900;P07900-2 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1 Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha 1 115659000.0 38260000.0 30912000.0 46487000.0 True False 58043217.180667385 25395512.08344164 37298824.074024126 1.0 0.43752764434808405 0.6426043538890424 25.790624150569357 -10.107832667875655 5.175339748950112 1.0000111026451488 0.5400659991179014 0.870239709106992 0.08372221608636718 1.0725551789525809e-05 1.8488793555207946e-06 0.08106564258619833 0.027021229050506686 7.801306341920539e-11 10.107832667875655 -0.4599451035272474 EMLQQSK(ub)ILK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EMLQQSKILK 10 1 P08238;Q58FF7;P07900;P07900-2 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1 Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha 1 102414900.0 50958400.0 34467900.0 16988600.0 True False 69799097.57897994 32944994.20789696 12976242.571199749 1.0 0.4719974233279826 0.18590845757735922 26.05670504840081 -8.836863131346052 0.2580209744153346 1.2757581287262214 7.167274101554931e-15 0.9991341820227816 0.009922249626008491 0.3505592630725294 0.08131072550261272 0.19809162926974555 0.1102268331687222 1.4559178433040534e-09 8.836863131346052 -1.2757581287262143 EMLQQSK(ub)ILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EMLQQSKILK 10 1 P08238;Q58FF7;P07900;P07900-2 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1 Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha 1 138196500.0 67700000.0 62066000.0 8430500.0 True False 56295549.618522264 61731638.138863586 10193278.571772171 1.0 1.0965633794709901 0.18106721829425743 25.746517540387988 -6.880835738161486 1.07516628092468 1.0605297579568944 0.11514792779426741 0.9743516666572561 0.06577483083706269 0.12689056069536583 0.2678557214222658 0.047090920021189114 0.11411978321808525 1.3157223796386195e-07 6.880835738161486 -0.945381830162627 down EMLQQSK(ub)ILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EMLQQSKILK 10 1 P08238;Q58FF7;P07900;P07900-2 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1 Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha 1 93031000.0 38260000.0 27970000.0 26801000.0 True False 49528324.21735076 26413444.912394002 21923493.001482554 1.0 0.5332997901661459 0.44264556388528725 25.561750472661807 -13.999999999999957 0.23039227388247907 3.9514988976231558 0.39873289334921674 0.9995103318761495 0.005403604767705189 13.303518961481712 0.15197721548842533 17.965933039627195 0.04694307422207789 1.0000000000000981e-14 13.999999999999957 -3.552766004273939 EMNDAAMFYTNR ddPTM_RPMI8226_Bortezomib_1h_R1 2 EMNDAAMFYTNR 12 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 15894270.0 2312470.0 6194200.0 7387600.0 False True 3031670.5639913343 5270049.504802488 6623202.018863118 1.0 1.7383318515532322 2.1846707546427364 21.53168156111882 -8.95152511022613 0.1453923919894636 2.197886716363624e-18 2.989337270661615 0.9998615306647352 0.005748465899636364 0.440220917216807 0.04653038793494755 0.5363106934459256 0.3463247887840404 1.1180851767831422e-09 8.95152511022613 2.989337270661615 EMNDAAMFYTNR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EMNDAAMFYTNR 12 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 13526270.0 2312470.0 5310100.0 5903700.0 False True 3167452.6511519942 5075482.223847517 4509367.650518112 1.0 1.6023861389061578 1.4236574772090331 21.59489162264171 -10.133000826170438 4.4571887805528645 0.9999302728583719 1.513021808077272 0.9165662292764121 0.07296567066022605 50956365.466303095 4.799311746887666 36663.303335327204 0.024978089830322327 7.362056969888883e-11 10.133000826170438 0.5130915352189 EMNPALGIDCLHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EMNPALGIDCLHK 13 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 7155000.0 2724100.0 1647600.0 2783300.0 False True 2637624.9365969487 2305495.2721204944 2054270.2327898 1.0 0.8740800256063068 0.7788333376314716 21.330808001016955 -6.9742131794739635 0.1206660365194395 1.1696500178921756 0.4808148760459671 0.9999994303865894 6.811889766361103e-05 0.07495767553914147 0.0035951856206306964 0.006657796816407014 0.013677171692137606 1.0611745370847663e-07 6.9742131794739635 -0.6888351418462084 EMQPTHPIR ddPTM_RPMI8226_Bortezomib_2h_R1 2 EMQPTHPIR 9 0 P27348;P31946;P31946-2;P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6 P27348;P31946;P31946-2;P63104 YWHAQ;YWHAB;YWHAZ 14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta 0 18385810.0 5544770.0 2011820.0 10829220.0 False True 5368754.31140365 2815150.217502703 7992722.412363729 1.0 0.5243581758850663 1.488748031435629 22.356155954138845 -6.772631276346515 1.5646611984530157 0.7280947348412026 1.4946813387982039 0.740398541552721 0.20060601005143647 0.26221060038026744 1.2672746956768823 0.10104228823160233 0.23991922632439366 1.6879855466021064e-07 6.772631276346515 0.7665866039570013 EMQQSEAQINTAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EMQQSEAQINTAKR 14 1 Q96GQ7;B7Z6D5 Q96GQ7 DDX27 Probable ATP-dependent RNA helicase DDX27 1 3323350.0 1026100.0 1581200.0 716050.0 True False 853247.6139374558 1572681.7617563752 865772.7443588704 1.0 1.8431715905995547 1.0146793617899676 19.702604949344998 -10.295983418495801 4.6371455283998815 0.9997667860637488 1.4289254761959167 0.2632845256265005 0.33823053607806075 0.0008159303871166214 0.0001238744564281461 0.3276662952115172 0.10916343611686995 5.0584397492147694e-11 10.295983418495801 0.4291586901321679 EMSGSTSELLIK(ub)ENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMSGSTSELLIKENK 15 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 76879300.0 24420100.0 30301500.0 22157700.0 True False 32014987.584584765 25780634.314321887 19865033.75566671 1.0 0.805267665533479 0.6204916901242759 24.932244114697728 -6.971761715313206 0.21193057232076631 1.094389792228295 0.326200112616817 0.999993055229953 0.00040830152226411533 0.07573513100658287 0.006946664796034666 0.005449313179311718 0.019062671733028058 1.0671814919161268e-07 6.971761715313206 -0.768189679611478 EMSGSTSELLIK(ub)ENK ddPTM_RPMI8226_Bortezomib_2h_R1 2 EMSGSTSELLIKENK 15 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 123821600.0 38206800.0 35069800.0 50545000.0 True False 36993946.047344975 49073354.02659095 37305748.18250293 1.0 1.326523911879709 1.008428463802129 25.140785861383346 -10.498141139753818 5.970456654296211 0.9998311014296694 1.1674761878409083 0.26985890472349916 0.1298619228820086 0.0002922490055744232 2.4565554914781253e-05 0.1258643967237321 0.04191275538570759 3.175841797868021e-11 10.498141139753818 0.16764508641123899 EMSGSTSELLIK(ub)ENK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EMSGSTSELLIKENK 15 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 101317600.0 56531900.0 38668000.0 6117700.0 True False 85763025.33548816 31767393.285537053 4908533.913516841 1.0 0.3704089630848403 0.05723368426330132 26.353852462725534 -8.694910819593124 0.3949969917995721 1.121772345704545 2.0486867680553533e-19 0.9970310205045397 0.021361714902749566 0.28681581769921954 0.13300938356337325 0.12888670537193292 0.07609290859321534 2.018780868639065e-09 8.694910819593124 -1.121772345704545 EMSGSTSELLIK(ub)ENK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EMSGSTSELLIKENK 15 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 95642900.0 31702900.0 26834500.0 37105500.0 True False 43424318.86865844 25648863.060175166 28341945.11176038 1.0 0.5906566580296385 0.652674488631213 25.371999883958594 -10.519956356119906 6.238029538306286 1.0003831328865784 0.6216655733304554 0.9802449864067185 0.025318673321370288 0.0001350411336159381 1.039192593292551e-05 0.024538779393134057 0.00817156667681109 3.020255221918036e-11 10.519956356119906 -0.3787175595561231 EMSGSTSELLIK(ub)ENK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 EMSGSTSELLIKENK 15 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 131075200.0 38206800.0 55818500.0 37049900.0 True False 31770647.048226874 55517794.6613952 44796862.79061757 1.0 1.7474555861931573 1.410007883145008 24.921191136817622 -10.217046978410192 4.891897774168444 0.9999144279533676 1.5787317346700191 0.7968204130112384 0.13776244789373632 0.0001285952821759929 2.058168563149804e-05 0.13340751386411764 0.04446263886828655 6.066707013851199e-11 10.217046978410192 0.5788173067166515 EMSGSTSELLIK(ub)ENK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EMSGSTSELLIKENK 15 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 123177400.0 56531900.0 33116700.0 33528800.0 True False 73181658.96034649 31273726.533081066 27426902.434540078 1.0 0.4273437768065185 0.3747783641991685 26.124978784817984 -13.999999999999998 0.3379315768123404 7.540428956123347 0.3663117938823707 0.9997310588493713 0.004643606511761247 19.515668176264942 0.1863452403015348 91.086438876344 0.016361738842684683 1.0000000000000041e-14 13.999999999999998 -7.174117162240976 EMSVQEAYK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMSVQEAYKK 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 3523800.0 1037500.0 1440700.0 1045600.0 True False 1360172.5471642914 1225753.1758046146 937411.3421034262 1.0 0.9011747651870224 0.6891856066774438 20.37535824811461 -6.958652152158757 0.45402965278518276 1.0065615589003565 0.5753381265106701 0.9997168979122082 0.002181647651407004 0.0801861408960869 0.02293709764353651 0.002851011008357562 0.01752507739613746 1.0998864399507062e-07 6.958652152158757 -0.4312234323896864 EMSVQEAYK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EMSVQEAYKK 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 9404800.0 1218500.0 3067700.0 5118600.0 True False 1179819.384473179 4292648.607844159 3777885.1052915184 1.0 3.6383947105267658 3.202087671223037 20.170134587327333 -9.37507404097758 8.781967872972958 0.9999999999999262 3.4202411908751507 0.9762058704166323 0.17812160291392645 0.0 0.0 0.17246550170594724 0.05748850014032636 4.2162461635359827e-10 9.37507404097758 2.4202411908752244 EMSVQEAYK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 EMSVQEAYKK 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 23417700.0 3026300.0 2939100.0 17452300.0 True False 4591118.352165545 2414594.641706888 14002845.25538516 1.0 0.5259273354536741 3.0499856856838115 22.130414192374563 -6.858144147529534 1.1951298644500048 0.7439547483650372 3.1679126732146705 0.9513326715787752 0.24164082029010456 0.14873320982506977 0.4047468429625102 0.1578120450094203 0.3676322380488523 1.3862956244147195e-07 6.858144147529534 2.4239579248496335 up EMSVQEAYK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EMSVQEAYKK 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 4765570.0 1037500.0 818570.0 2909500.0 True False 1421091.7873832714 782402.8707509954 2222336.0230334247 1.0 0.5505646276315997 1.5638230005716416 20.4385683096375 -6.786132383164328 1.511809272516543 0.7475442641915736 1.5734727447035524 0.7885409159234058 0.1906243001335212 0.24116100409386465 1.088930971745366 0.09927266649068459 0.2330873997335438 1.6363176573222837e-07 6.786132383164328 0.8259284805119788 EMSVQEAYK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EMSVQEAYKK 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 8631800.0 1218500.0 4689500.0 2723800.0 True False 1013236.7387026511 4664236.732707133 3293333.986571734 1.0 4.603304000483859 3.2503104760971464 19.95053986276161 -9.838552395326934 8.105784953716535 0.9999999988772909 3.926807238290503 0.8618650079115293 0.5523572933395537 1.2960287385477328e-08 0.0 0.5348176535497754 0.1782725498550245 1.450265796870001e-10 9.838552395326934 2.926807239413212 EMSVQEAYK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EMSVQEAYKK 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 18815700.0 3026300.0 4186700.0 11602700.0 True False 3917605.007291392 3953706.4645949183 9491127.653755527 1.0 1.0092151856137448 2.422686216729551 21.901540514467012 -6.908329946304339 0.9070322866773113 0.9538911745940563 2.598975843257705 0.9902759356145237 0.06592116018244791 0.10553276804046656 0.14483429141366122 0.0535287888389521 0.14610858913289268 1.2350088043879436e-07 6.908329946304339 1.6450846686636487 up EMTSSVLTVNGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMTSSVLTVNGK 12 0 Q6UXZ0-2;Q6UXZ0 Q6UXZ0-2 TMIGD1 Transmembrane and immunoglobulin domain-containing protein 1 0 59755000.0 21401000.0 15825000.0 22529000.0 False True 28056918.247578822 13463971.685366852 20197915.193427816 1.0 0.4798806328820069 0.719890724105838 24.741853217249865 -10.376596701469142 5.951057181851385 1.0000780324817886 0.5998856784939236 0.7874831594224909 0.09798370943620605 0.0001014633966876762 1.062869336842884e-05 0.09489071188027684 0.03162410623717087 4.2014896548035475e-11 10.376596701469142 -0.400192353987865 EMTSSVLTVNGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EMTSSVLTVNGK 12 0 Q6UXZ0-2;Q6UXZ0 Q6UXZ0-2 TMIGD1 Transmembrane and immunoglobulin domain-containing protein 1 0 52514000.0 12089000.0 23779000.0 16646000.0 False True 18339896.824283544 19535451.66382499 13355910.803799003 1.0 1.0651887440259986 0.7282435082249029 24.12848218692241 -6.856541779944037 1.2030296821322362 1.0350945610655973 0.7129684039759361 0.9492989761698672 0.03285659404241569 0.150411723804646 0.41562439721204214 0.02132891762374816 0.049611751130145494 1.3914199311976688e-07 6.856541779944037 -0.3221261570896612 EMTSSVLTVNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EMTSSVLTVNGK 12 0 Q6UXZ0-2;Q6UXZ0 Q6UXZ0-2 TMIGD1 Transmembrane and immunoglobulin domain-containing protein 1 0 53179000.0 12089000.0 25556000.0 15534000.0 False True 15649448.809815831 24133786.13447053 12706971.39229992 1.0 1.5421492748890333 0.8119756514574306 23.89960850901486 -6.707847301708628 1.8026703740738803 1.3340279485910675 0.8137821471376532 0.45495785477237194 0.22853690838833424 0.37942385348947044 2.4020827486061194 0.10093483576698532 0.2571135047899848 1.9595335259722053e-07 6.707847301708628 -0.5202458014534144 EMTVEAEK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EMTVEAEKK 9 1 Q9P2G1 Q9P2G1 ANKIB1 Ankyrin repeat and IBR domain-containing protein 1 1 8075700.0 1826300.0 2539500.0 3709900.0 True False 1768325.1061660796 3553535.593317546 2738165.8953856537 1.0 2.0095487989886633 1.5484516313418712 20.753952107591687 -10.139910220088138 4.731470807964289 0.9999336183731417 1.7790002151722157 0.7919116563823352 0.18824213045338695 0.00013182559078695003 2.3963344591132007e-05 0.18228009180585225 0.06075488635499932 7.245857352218627e-11 10.139910220088138 0.7790665967990741 EMTVEAEK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EMTVEAEKK 9 1 Q9P2G1 Q9P2G1 ANKIB1 Ankyrin repeat and IBR domain-containing protein 1 1 7212200.0 1826300.0 3131600.0 2254300.0 True False 1518649.368808086 3114729.4492260655 2725663.707294466 1.0 2.0509865629290487 1.794794613738724 20.534357383025963 -10.32129440456907 6.519800416257112 0.9999653163181831 1.9228905883338865 0.9453625787319674 0.10458992528755515 5.2731224316147146e-05 5.489184116536322e-06 0.10127253785573573 0.033756253234981534 4.772056702840636e-11 10.32129440456907 0.9229252720157034 EMVK(ub)AEEDTQFNYHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMVKAEEDTQFNYHR 15 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 10263100.0 3064000.0 5804600.0 1394500.0 True False 4016933.6718182126 4938576.3061535815 1250210.5169885526 1.0 1.2294393459372706 0.3112350412354858 21.937663208917918 -6.8405298508009285 1.2798257521381584 1.1220566115177182 0.2806982613869007 0.9253689164330234 0.106591086535764 0.16818920410922367 0.5348888391075862 0.06529822375392048 0.15046539492073058 1.443677371146673e-07 6.8405298508009285 -0.8413583501308175 down EMVK(ub)AEEDTQFNYHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EMVKAEEDTQFNYHR 15 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 9964900.0 4330200.0 0.0 5634700.0 True False 4192740.171231646 0.0 4158803.032623397 1.0 0.0 0.9919057377222879 21.9994619968635 -11.990308792476428 14.18135106883804 0.8695073629504247 0.5463575819750448 0.0 0.4840148792144421 0.0 0.0 0.0 0.13850642824202983 1.0225656681241301e-12 11.990308792476428 -0.32314978097537994 EMVK(ub)AEEDTQFNYHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EMVKAEEDTQFNYHR 15 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 29685900.0 13865200.0 6373500.0 9447200.0 True False 21034522.081897285 5236099.1286172075 7579956.779145141 1.0 0.2489288374715913 0.36035792729841 24.326255703715457 -10.383439712151894 6.949669058598368 1.000036084110683 0.3046433824340659 0.9811044943796186 0.045490735429742954 2.5434830588223583e-05 2.2564497598229047e-06 0.04404848645324516 0.014682071727176844 4.135807227704103e-11 10.383439712151894 -0.695392701676617 EMVK(ub)AEEDTQFNYHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EMVKAEEDTQFNYHR 15 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 11803600.0 3064000.0 3508000.0 5231600.0 True False 4196843.601486603 3353004.9605952976 3996003.8281841115 1.0 0.7989349327689025 0.9521450422333226 22.00087327044081 -10.53486727691294 4.889495458747912 1.0006618590369016 0.8755399875011066 0.4680512218919264 0.06254776527065146 0.0004536519558039036 4.315550193233515e-05 0.0608803544821135 0.02018720443630737 2.918318734040471e-11 10.53486727691294 -0.12512187153579502 EMVK(ub)AEEDTQFNYHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EMVKAEEDTQFNYHR 15 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 14841600.0 4330200.0 6727800.0 3783600.0 True False 3600753.1603859016 6691556.006036264 4574733.26661019 1.0 1.8583767639654347 1.2704934392447786 21.779867272297775 -10.03646233153592 5.97010075336307 0.9999990018682532 1.5644351016051516 0.5513868937702674 0.24000236230958008 3.1886591705078864e-06 5.144755657415563e-07 0.23238169662927843 0.07746042935626347 9.194702214516207e-11 10.03646233153592 0.5644360997368985 EMVK(ub)AEEDTQFNYHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EMVKAEEDTQFNYHR 15 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 25390800.0 13865200.0 7295600.0 4230000.0 True False 17948774.72395223 6889593.446652176 3460183.4034652137 1.0 0.38384756355865174 0.19278103696112905 24.097382025807907 -13.999999999989182 0.16395587991652155 4.061207197600424 0.012916860343634824 0.9995265270409447 0.007494825837714968 12.0383968753799 0.12808156192115766 11.717337822898463 0.16478284838627685 1.0000000000249094e-14 13.999999999989182 -4.048290337256788 EMVLELIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMVLELIR 8 0 Q96AE4;E9PEB5;Q96AE4-2 Q96AE4;Q96AE4-2 FUBP1 Far upstream element-binding protein 1 0 4968400.0 1390100.0 1292800.0 2285500.0 False True 1822434.5617475507 1099919.2792949304 2049018.3840640597 1.0 0.6035439090006101 1.1243302926055327 20.797435581880656 -6.703205541474984 1.8192851589496775 0.7545885675745696 1.1228829105954332 0.4327741803501911 0.16725409757399093 0.38894448852203345 2.5048746340245245 0.07327914874270348 0.1877231985248308 1.9805894370484305e-07 6.703205541474984 0.3682943430208636 EMVLELIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EMVLELIR 8 0 Q96AE4;E9PEB5;Q96AE4-2 Q96AE4;Q96AE4-2 FUBP1 Far upstream element-binding protein 1 0 5414700.0 1390100.0 2165100.0 1859500.0 False True 1904057.5360399885 2069438.7229717444 1420324.3976046247 1.0 1.0868572423896976 0.7459461548407723 20.860645643403547 -6.839135225031276 1.2863660754927817 1.0462125099521553 0.7349208845947461 0.9229679912045252 0.04014658699469759 0.16980682480540818 0.5461853211454835 0.024475475007113702 0.056375589467396146 1.448320823816012e-07 6.839135225031276 -0.3112916253574092 EMVQEDQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 EMVQEDQKR 9 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 8467200.0 3427300.0 3593000.0 1446900.0 True False 4493223.49002041 3056938.4054043028 1297188.6676448425 1.0 0.6803441698802337 0.28869889746769534 22.099319391685263 -7.217190771855964 0.33687229061533913 1.0526207435943273 8.29021330181103e-12 0.9998481479306959 0.0035844935792543266 0.09179462090973567 0.020098313421886404 0.009574413009612273 0.042917162427093536 6.064698680009154e-08 7.217190771855964 -1.052620743586037 down EMVQEDQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 EMVQEDQKR 9 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 11583500.0 2710100.0 5923500.0 2949900.0 True False 2624069.3589337417 8288784.440644416 2177232.6948969318 1.0 3.1587520400041793 0.829716138212758 21.323374422842406 -6.663203946127796 1.9615364803003332 2.385871043609734 0.8393615432660532 0.24933965852605322 0.9184461416630076 0.4768719129859129 3.5304702279874696 0.37785278271959166 1.0185331141611507 2.1716811107230436e-07 6.663203946127796 -1.5465095003436806 EMVQEDQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EMVQEDQKR 9 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 14149200.0 3427300.0 6093700.0 4628200.0 True False 4694465.429299938 5824460.1848288365 3535114.480771029 1.0 1.2407078660066753 0.7530387717219175 22.162529453208155 -6.7725213239639475 1.5649910507074782 1.137623179596915 0.7500445193894761 0.740007086570512 0.10151781561114492 0.26239261776537315 1.268660512526255 0.051121628801246474 0.12140203686504997 1.6884129559675735e-07 6.7725213239639475 -0.3875786602074388 ENAGAAEK(ub)SITILSTPEGTSAACK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENAGAAEKSITILSTPEGTSAACK 24 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 34120800.0 5606100.0 9307700.0 19207000.0 True False 8504863.56080867 7646668.21360797 15410728.03127283 1.0 0.8990935785077897 1.8119900361820183 23.019856660977254 -6.879481639426606 1.0827227646272728 0.9378839291130386 1.8760374130772355 0.9732633067929175 0.0668184148030652 0.12808854648450696 0.27508927727403 0.04756232244511053 0.11486447763173538 1.319831108740495e-07 6.879481639426606 0.9381534839641968 ENALK(ub)IWDLQGSEEPVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENALKIWDLQGSEEPVFR 18 1 Q6RFH5;Q6RFH5-2;E9PS41 Q6RFH5 WDR74 WD repeat-containing protein 74 1 21004300.0 2721000.0 3723300.0 14560000.0 True False 2634623.3444000976 5210033.106752994 10746299.209362814 1.0 1.9775248396803815 4.078874967916805 21.32916529285367 -6.958609154447053 0.45461092402930686 0.9353399106615353 5.205008246610967 0.9997150870898089 0.02168244388259213 0.08020173948063876 0.022995661479939655 0.028286767971967396 0.1737046631447825 1.099995340577408e-07 6.958609154447053 4.269668335949431 ENALK(ub)IWDLQGSEEPVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENALKIWDLQGSEEPVFR 18 1 Q6RFH5;Q6RFH5-2;E9PS41 Q6RFH5 WDR74 WD repeat-containing protein 74 1 17657900.0 2721000.0 3596900.0 11340000.0 True False 2262632.060738541 3577522.7857712503 13711141.569764104 1.0 1.5811332508934388 6.059819361566316 21.109570568287946 -6.930797620275165 0.7402154178426452 0.9338677776645342 6.9982296333126355 0.9966926798877669 0.13001303247790708 0.09222589683460111 0.07566670909549038 0.11901479676221018 0.403481528700274 1.1727417318222936e-07 6.930797620275165 6.064361855648102 up ENALVQMADGNQAQLAMSHLNGHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENALVQMADGNQAQLAMSHLNGHK 24 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;K7EK45 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 21640000.0 2201000.0 3034600.0 16404400.0 False True 2885532.3145143175 2581849.508778153 14707030.05011618 1.0 0.8947567475821946 5.096816963767607 21.460406056884516 -6.901158306158673 0.9539422655201887 0.8308025807709613 5.548376767559964 0.9871330687767835 0.22193475406994478 0.11055688084050047 0.17266146155508508 0.174105925112402 0.4556706129966417 1.2555722073751624e-07 6.901158306158673 4.717574186789003 up ENALVQMADGNQAQLAMSHLNGHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENALVQMADGNQAQLAMSHLNGHK 24 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;K7EK45 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 22579300.0 5430800.0 2057500.0 15091000.0 False True 5258402.22666962 2879070.4797207587 11138214.37970427 1.0 0.5475181158867344 2.1181746659115115 22.326193070395227 -6.829673785752591 1.3294809554765825 0.7581754611424113 2.1601247303758213 0.9052002559835934 0.20325303168193393 0.1812141273578861 0.6265561948100286 0.1200443161957424 0.27624304180478 1.4802198171849044e-07 6.829673785752591 1.40194926923341 up ENALVQMADGNQAQLAMSHLNGHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENALVQMADGNQAQLAMSHLNGHK 24 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;K7EK45 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 21634800.0 7230600.0 8504800.0 5899400.0 False True 10969348.827666864 6987051.991694313 4733381.00420112 1.0 0.6369614187190025 0.43150975309150513 23.3869745499363 -10.003452128006861 0.12070473121245232 1.7576371713083918 7.061703336141315e-13 0.9998685651869471 0.0026945951123373193 1.5902038653328407 0.05613107066524477 0.6102930344951033 0.236735828903526 9.92082689830065e-11 10.003452128006861 -1.7576371713076857 ENALVQMADGNQAQLAMSHLNGHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENALVQMADGNQAQLAMSHLNGHK 24 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;K7EK45 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 30406900.0 2201000.0 9976200.0 18229700.0 False True 3014769.1797885103 9535418.49711825 13924220.3124566 1.0 3.1629016778615107 4.6186687875830685 21.523616118407407 -8.197792730520847 0.2441512068704563 2.502052858899383e-16 5.914793698110295 0.9995183435020036 0.032627851761967294 0.09100686636720091 0.05389673878115362 0.4638217019570369 0.5271222331999672 6.341723013351538e-09 8.197792730520847 5.914793698110295 ENALVQMADGNQAQLAMSHLNGHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENALVQMADGNQAQLAMSHLNGHK 24 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;K7EK45 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 11302600.0 5430800.0 2373100.0 3498700.0 False True 4515950.82523295 2360315.639276531 4230261.993838952 1.0 0.5226619444322176 0.9367378338582194 22.106598345829504 -10.197632058515461 7.850997087486838 1.0000001356618864 0.7296998891452187 0.36231030990419455 0.1690457739804688 4.0133137586384043e-07 4.131781254384142e-08 0.16367794732899055 0.05455928894775821 6.344069637366789e-11 10.197632058515461 -0.27030024651666773 ENATVAHLVGALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENATVAHLVGALR 13 0 Q13158 Q13158 FADD FAS-associated death domain protein 0 4585910.0 1865400.0 961010.0 1759500.0 False True 2445557.464559296 817631.0539876408 1577443.8183157812 1.0 0.334333200440654 0.6450242291076345 21.221731934167817 -10.521305989966983 6.34658831477906 1.000467487359594 0.4896787147743621 0.7824778931479164 0.12683908131575386 0.0008397352426951299 6.33373383378598e-05 0.12291815187349331 0.04093713746534689 3.010883904425314e-11 10.521305989966983 -0.5107887725852319 ENAYDLEANLAVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENAYDLEANLAVLK 14 0 Q9UBQ5-2;Q9UBQ5;K7ERF1;K7ES31 Q9UBQ5-2 EIF3K Eukaryotic translation initiation factor 3 subunit K 0 5922900.0 1258000.0 1766600.0 2898300.0 False True 1649250.1824893304 1503030.1661528647 2598411.7184567363 1.0 0.9113415187768751 1.5755109479719862 20.65337883387225 -6.873250014353593 1.1167086096893544 0.9487190346234209 1.6168970140820973 0.9678230427128487 0.052814429239211244 0.13377945722262327 0.3098231213109276 0.036626000829994954 0.0872408709214356 1.3389056852029643e-07 6.873250014353593 0.6681779794586764 ENAYDLEANLAVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENAYDLEANLAVLK 14 0 Q9UBQ5-2;Q9UBQ5;K7ERF1;K7ES31 Q9UBQ5-2 EIF3K Eukaryotic translation initiation factor 3 subunit K 0 10972700.0 3342100.0 2460300.0 5170300.0 False True 3236006.8648730526 3442710.6202950045 3816043.3243247624 1.0 1.0638761795179508 1.179244508331556 21.625783237632177 -6.961988892704417 0.4064340758544156 0.9940910374030161 1.2532863212697778 0.9998369913412339 0.00094702237872749 0.07899815153400652 0.018561493472462363 0.0014844930655975913 0.009643807357742187 1.0914682509306575e-07 6.961988892704417 0.2591952838667617 ENAYDLEANLAVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENAYDLEANLAVLK 14 0 Q9UBQ5-2;Q9UBQ5;K7ERF1;K7ES31 Q9UBQ5-2 EIF3K Eukaryotic translation initiation factor 3 subunit K 0 5549800.0 1258000.0 1145900.0 3145900.0 False True 1723116.5961717179 1095270.3490154357 2402903.211844252 1.0 0.6356333352303724 1.394509934605023 20.71658889539514 -6.776160698074326 1.550997403129745 0.7926562238107716 1.39979572661533 0.753512194380471 0.15385351628516092 0.2565861581463449 1.2188978398983084 0.0781543763356581 0.1849992720868803 1.674323226653266e-07 6.776160698074326 0.6071395028045584 ENAYDLEANLAVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENAYDLEANLAVLK 14 0 Q9UBQ5-2;Q9UBQ5;K7ERF1;K7ES31 Q9UBQ5-2 EIF3K Eukaryotic translation initiation factor 3 subunit K 0 7658400.0 3342100.0 1909600.0 2406700.0 False True 2779104.2301338804 1899312.6057740785 2909929.8426764794 1.0 0.6834261864595778 1.0470747412508155 21.406188513066454 -6.676542516739925 1.9138032092050414 0.7990888565868368 1.0456688458898602 0.30856496939384814 0.13427281960349646 0.4462316281109766 3.156736507169339 0.056355181865244366 0.14931474559636376 2.1059957152636155e-07 6.676542516739925 0.24657998930302338 ENCMYQACPTQDCNKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENCMYQACPTQDCNKK 16 1 P27694 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 3560740.0 741540.0 1040900.0 1778300.0 True False 1015707.377365003 994909.5962040025 1358302.165238131 1.0 0.9795238455243329 1.337296740683231 19.954053394632215 -6.893331588515788 1.0024317812770687 0.9822835350602448 1.370158764611406 0.9829475609994651 0.021421501774098753 0.11648296656700033 0.20637476660837295 0.01620658376317572 0.04092066047630922 1.2784048555603822e-07 6.893331588515788 0.38787522955116116 ENCPVPGK(ub)PGEAVAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENCPVPGKPGEAVAAR 16 1 P04183;K7ERV3 P04183 TK1 Thymidine kinase, cytosolic;Thymidine kinase 1 8758330.0 4137300.0 3759000.0 862030.0 True False 5424040.365670189 3198171.852467236 772835.404775647 1.0 0.5896290655779574 0.14248334316740582 22.370936484364712 -7.663107093580618 0.4294195057518803 1.0344486479204895 8.766376838885206e-15 0.9978359307735397 0.016290543269567886 0.11887484954436235 0.06839860104430198 0.026410960873004572 0.07438824879198795 2.1721654740088648e-08 7.663107093580618 -1.0344486479204809 down ENDIK(ub)SYFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENDIKSYFGR 10 1 P39748;F5H1Y3 P39748 FEN1 Flap endonuclease 1 1 12393400.0 2642000.0 5214700.0 4536700.0 True False 3463687.5851643966 4436687.086741392 4067285.8030992923 1.0 1.2809143370044482 1.1742646249391016 21.723877378239788 -10.072607610373671 4.299329492415427 0.9999773328162497 1.2275894808890826 0.858595037349637 0.043539562745539 6370647.710521871 7462679.605536544 1104.8216309791214 0.01490475049682203 8.460429085935872e-11 10.072607610373671 0.22761214807283292 ENDIK(ub)SYFGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENDIKSYFGR 10 1 P39748;F5H1Y3 P39748 FEN1 Flap endonuclease 1 1 20211200.0 2999800.0 6851400.0 10360000.0 True False 2904572.9910074985 9587199.749578992 7646405.206661988 1.0 3.3007260548317348 2.6325402151487016 21.46989465411171 -9.948058500009921 5.3401775094094255 0.9999952557344685 2.966633134999277 0.9203202314031693 0.2727857267945038 1.540787927756335e-05 3.035010063880935e-06 0.26412428088505 0.0880412147419308 1.1270456314939995e-10 9.948058500009921 1.9666378792648085 ENDIK(ub)SYFGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENDIKSYFGR 10 1 P39748;F5H1Y3 P39748 FEN1 Flap endonuclease 1 1 57162400.0 6589300.0 4952100.0 45621000.0 True False 9996449.84235683 4068359.064066104 36603989.35360536 1.0 0.40698039086113397 3.6616988961928665 23.2529843937915 -6.859714866410569 1.1871543647614957 0.6784838054378718 3.818465551913885 0.9532920957949607 0.30589039983625566 0.1470998845012421 0.394092998361474 0.20098781432549084 0.46902253679188394 1.3812908456689122e-07 6.859714866410569 3.139981746476013 up ENDIK(ub)SYFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENDIKSYFGR 10 1 P39748;F5H1Y3 P39748 FEN1 Flap endonuclease 1 1 10762300.0 2642000.0 3310000.0 4810300.0 True False 3618818.7973654037 3163753.2552937386 3674206.2112382525 1.0 0.8742502546955474 1.0153053847054105 21.78708743976268 -11.79986351366279 23.089344066487037 0.9442327730251445 0.950300038071051 0.0 0.06449638454531965 0.0 0.0 0.0 0.018884542013265646 1.5853913573475943e-12 11.79986351366279 0.006067265045906489 ENDIK(ub)SYFGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENDIKSYFGR 10 1 P39748;F5H1Y3 P39748 FEN1 Flap endonuclease 1 1 9054900.0 2999800.0 0.0 6055100.0 True False 2494466.613672719 0.0 7321193.414380846 1.0 0.0 2.934973502652542 21.250299929545985 -6.814760188782083 1.394425104499922 0.45798981207279477 2.992107086294704 0.8718947775643383 0.436049710040128 0.20038053332310052 0.7669569904581456 0.24582102541567458 0.5675107993648966 1.5319331398023964e-07 6.814760188782083 2.5341172742219094 ENDIK(ub)SYFGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENDIKSYFGR 10 1 P39748;F5H1Y3 P39748 FEN1 Flap endonuclease 1 1 70708500.0 6589300.0 6171200.0 57948000.0 True False 8529978.744521433 5827767.295079219 47402058.59669082 1.0 0.6832100606138357 5.557113331277154 23.02411071588395 -6.891380839649503 1.0141971476687124 0.746722053372774 5.987803542245253 0.981766835897722 0.3006678967219063 0.11802920133260436 0.215369737945687 0.22547108846509595 0.5649604035125414 1.2841600659289948e-07 6.891380839649503 5.241081488872479 up ENEAYQASCK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENEAYQASCKER 12 1 K7EQN9;Q9UJT1-6;Q9UJT1-5;Q9UJT1-2;Q9UJT1;Q9UJT1-3 K7EQN9 TUBD1 Tubulin delta chain 1 32492260.0 1821100.0 5577560.0 25093600.0 True False 2762741.840243427 4582200.840324814 20133838.96108442 1.0 1.6585700384951905 7.287629509136624 21.39766932756531 -6.928885410025554 0.7558824439001078 0.9107659113476525 8.411125587957622 0.9963146700562271 0.17129239895002807 0.09322067613514787 0.08054507231099109 0.15503345159096654 0.512489850879119 1.177916729581541e-07 6.928885410025554 7.500359676609969 up ENEAYQASCK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENEAYQASCKER 12 1 K7EQN9;Q9UJT1-6;Q9UJT1-5;Q9UJT1-2;Q9UJT1;Q9UJT1-3 K7EQN9 TUBD1 Tubulin delta chain 1 26672110.0 1821100.0 461110.0 24389900.0 True False 2357449.8492477154 435448.8231517333 19951188.461507376 1.0 0.18471180767246825 8.463038341143923 21.16879564965776 -6.882695414152265 1.064689643701405 0.4742323314665752 9.080817014164957 0.9757938519388132 0.5795747619436928 0.12526759931497075 0.25810530709539276 0.41827543932892486 1.0187598730579734 1.3101004199334243e-07 6.882695414152265 8.606584682698381 up ENEENQK(ub)SYGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENEENQKSYGER 12 1 A0A087WTM5;H7BYJ1;Q969K3;Q969K3-2 A0A087WTM5 RNF34 E3 ubiquitin-protein ligase RNF34 1 4408120.0 619390.0 587330.0 3201400.0 True False 939659.9134744796 482516.372669765 2568641.8867765353 1.0 0.5135010717713987 2.7335867476550573 19.841779178119843 -6.849271749071579 1.2385701059961056 0.7405390612247396 2.8211154451525053 0.9392474621493035 0.2348512299886383 0.15825519087163342 0.46753799609419167 0.14840076531802254 0.34325857069530574 1.4149081589893047e-07 6.849271749071579 2.080576383927766 up ENEENQK(ub)SYGER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENEENQKSYGER 12 1 A0A087WTM5;H7BYJ1;Q969K3;Q969K3-2 A0A087WTM5 RNF34 E3 ubiquitin-protein ligase RNF34 1 4138750.0 619390.0 608060.0 2911300.0 True False 801812.565002219 574220.9264723017 2381473.272460586 1.0 0.7161535644813855 2.9701121888180877 19.612905500212293 -6.875312512107216 1.105554758703098 0.8329343627765203 3.1161903076483175 0.9697061630635175 0.17445921311732132 0.13186589343308347 0.2980367532824641 0.12202389485252538 0.2918877143726371 1.332562194352457e-07 6.875312512107216 2.2832559448717973 up ENELSAGLSK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENELSAGLSKR 11 1 E2QRF9;O75496;H7C608;C9K0U5 E2QRF9 GMNN Geminin 1 6015300.0 1186800.0 1294800.0 3533700.0 True False 1555906.2929875504 1101620.8870908709 3168066.621643922 1.0 0.7080252146648304 2.036155156594171 20.569323743585866 -6.849086905332062 1.2395813293323041 0.8443124601326197 2.0882930779872257 0.9389533056708566 0.1408020790673629 0.1584652255000966 0.4690346632525659 0.08890613390132121 0.20560635975386532 1.4155104981657027e-07 6.849086905332062 1.243980617854606 up ENELSAGLSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENELSAGLSKR 11 1 E2QRF9;O75496;H7C608;C9K0U5 E2QRF9 GMNN Geminin 1 14969000.0 1395200.0 3180800.0 10393000.0 True False 1350910.1396938695 4450910.027652869 7670761.51668321 1.0 3.2947491449442317 5.678217441184863 20.365500281493556 -6.9706483950164575 0.24219812367406876 0.1671575434605614 8.874935697583748 0.9999870077984698 0.006884494075168693 0.07609288161992514 0.008273685795959872 0.05609832381958171 0.23146461585050854 1.0699207369258674e-07 6.9706483950164575 8.707778154123186 ENELSAGLSK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENELSAGLSKR 11 1 E2QRF9;O75496;H7C608;C9K0U5 E2QRF9 GMNN Geminin 1 11328800.0 2765000.0 5115700.0 3448100.0 True False 4194707.148576724 4202763.365853463 2766581.523644079 1.0 1.0019205672747553 0.6595410419968859 22.000138662457953 -6.905635416377976 0.9249313981357191 1.0121187952334096 0.6191866400664896 0.9891679908901021 0.016751024454276457 0.10737586794103693 0.15494102746472682 0.013424961505278523 0.03602922683166168 1.2426950934881585e-07 6.905635416377976 -0.39293215516692004 ENELSAGLSK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENELSAGLSKR 11 1 E2QRF9;O75496;H7C608;C9K0U5 E2QRF9 GMNN Geminin 1 7609700.0 1186800.0 1118800.0 5304100.0 True False 1625592.0320640665 1069367.7166231512 4051380.8213684754 1.0 0.6578327744786868 2.4922494337181926 20.632533805108757 -6.858497559299292 1.1932829335678494 0.8150417749182787 2.5785743337470235 0.95179000127727 0.17487439841224262 0.14835808728365488 0.4022707453847947 0.11436777817563244 0.26653691335014174 1.3851679704372453e-07 6.858497559299292 1.7635325588287447 up ENELSAGLSK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENELSAGLSKR 11 1 E2QRF9;O75496;H7C608;C9K0U5 E2QRF9 GMNN Geminin 1 11912400.0 1395200.0 4307100.0 6210100.0 True False 1160170.6178399173 4283896.797407588 7508603.197741809 1.0 3.692471375790943 6.4719818639449995 20.145905556927833 -6.970726464058191 0.24020601843441494 0.004502762710549732 10.240363693462 0.999987506463372 0.007896414148927505 0.07606769676498346 0.008182244126791487 0.06634399410985216 0.2708744001498795 1.069728424605314e-07 6.970726464058191 10.23586093075145 ENELSAGLSK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENELSAGLSKR 11 1 E2QRF9;O75496;H7C608;C9K0U5 E2QRF9 GMNN Geminin 1 12552400.0 2765000.0 6050400.0 3737000.0 True False 3579347.0062983525 5713689.921270945 3056904.344858037 1.0 1.596293936077425 0.8540396724539403 21.771264984550402 -6.692840712996794 1.8562195349169164 1.3728400448037585 0.8565085201768026 0.3837652363903993 0.2520472118673072 0.4106115173688026 2.7451448834933965 0.10853540703802583 0.2816365677411686 2.0284265529227658e-07 6.692840712996794 -0.516331524626956 ENEQSLLEYLEK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENEQSLLEYLEKQR 14 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 7684300.0 1720300.0 3438500.0 2525500.0 True False 2255329.9594089 2925489.20316802 2264185.4863066254 1.0 1.2971446554697312 1.0039264883884425 21.104907087496215 -10.766063174805767 5.444224836443291 0.9919825836845643 1.150535571928946 0.2600414827238343 0.1197058154438836 0.012148189391794286 0.0005220036309470853 0.12087179157745233 0.03863488580486162 1.7137080042142965e-11 10.766063174805767 0.1585529882443818 ENEQSLLEYLEK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENEQSLLEYLEKQR 14 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 6266300.0 1581100.0 0.0 4685200.0 True False 1530908.845950383 0.0 3458005.5670128134 1.0 0.0 2.258792596410987 20.545956953134834 -6.786345222567775 1.5108009947677312 0.43844157425095065 2.280492879815895 0.7893128562266487 0.4241972099737743 0.24083468622819187 1.0859836187376417 0.22104913026276357 0.5189640824479634 1.6355159258668976e-07 6.786345222567775 1.8420513055649443 ENEQSLLEYLEK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENEQSLLEYLEKQR 14 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 22418800.0 2601000.0 5299800.0 14518000.0 True False 3945907.158570729 4354009.282473604 11648510.936534563 1.0 1.103424157615177 2.952048912563326 21.911925581278876 -6.918427128142605 0.8363065067576818 0.9568531547370894 3.2396345653711007 0.9937327848401959 0.07099757013161082 0.09910621073316785 0.11047409026223907 0.06066753358469864 0.17908410104067476 1.206626535485477e-07 6.918427128142605 2.282781410634011 up ENEQSLLEYLEK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENEQSLLEYLEKQR 14 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 5079000.0 1720300.0 0.0 3358700.0 True False 2356341.3993594646 0.0 2565444.2345978203 1.0 0.0 1.0887404665958833 21.168117149019107 -10.430563131339643 4.3367230440108075 1.0015456889377257 0.5443702332963479 0.1893083903254308 0.4444764342519723 0.006663463751358815 0.0008749504033983349 0.43171807630337117 0.14345415230254627 3.710537872340993e-11 10.430563131339643 -0.45717545564137774 ENEQSLLEYLEK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENEQSLLEYLEKQR 14 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 11534200.0 1581100.0 4882000.0 5071100.0 True False 1314754.7046062867 4855699.69699887 6131443.563882784 1.0 3.6932362211648795 4.6635646500454175 20.32636222856911 -9.274264457442719 0.34008176160035625 2.0100990302286263e-25 4.9447787599586075 0.99833735367219 0.06319373553278024 0.6686441540030401 0.13043248495242943 1.132464163077747 0.2914245816237685 5.317843381502819e-10 9.274264457442719 4.9447787599586075 ENFCNIHVSLVPQPSSTGEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENFCNIHVSLVPQPSSTGEQK 21 0 A0A3B3IRI2;P17812;B4E1E0;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 59044000.0 16684000.0 22310000.0 20050000.0 False True 21872885.568085816 18981434.963698868 17975418.3331807 1.0 0.8678066231642618 0.8218128457366497 24.382640223882184 -13.999999999999998 0.1472293210768663 1.6366406758321226 0.7695624045135598 0.9995757441687216 0.0015556882879057322 11.948444757249675 0.12069417529720965 2.1781653746248084 0.0469751303536363 1.0000000000000041e-14 13.999999999999998 -0.8670782713185627 ENFCNIHVSLVPQPSSTGEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENFCNIHVSLVPQPSSTGEQK 21 0 A0A3B3IRI2;P17812;B4E1E0;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 20097200.0 11128000.0 3432100.0 5537100.0 False True 10774747.731159236 4802555.428165057 4086767.40056063 1.0 0.4457232362180194 0.37929123748690696 23.36115075614623 -13.999999999999998 0.29929234995876847 6.035428791060304 0.36282547950058275 0.9996482517005496 0.005218966212789444 16.542484182815084 0.1737226956974981 51.563137724496265 0.02408136568090011 1.0000000000000041e-14 13.999999999999998 -5.672603311559721 ENFCNIHVSLVPQPSSTGEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENFCNIHVSLVPQPSSTGEQK 21 0 A0A3B3IRI2;P17812;B4E1E0;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 76271000.0 10499000.0 52257000.0 13515000.0 False True 15927750.579713227 42931330.06419545 10843754.32616507 1.0 2.695379353747289 0.6808088984000343 23.92503919870578 -6.683542900486864 1.8891920181483872 2.0692442863757314 0.6882295328383984 0.3404700978635735 0.7179900371574719 0.430694331683621 2.974898863088348 0.3046122419255664 0.7997978506445325 2.0723213413801306e-07 6.683542900486864 -1.381014753537333 ENFCNIHVSLVPQPSSTGEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENFCNIHVSLVPQPSSTGEQK 21 0 A0A3B3IRI2;P17812;B4E1E0;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 57884000.0 16684000.0 16392000.0 24808000.0 False True 22852525.668146983 15667747.238904806 18948861.336797796 1.0 0.6856024347778465 0.8291801795549315 24.445850285405076 -10.02914349254469 4.579462127242614 1.0000084766754058 0.7573913071513321 0.7919678872096292 0.05861536890454805 18423885.98046153 20174399.244464412 1295.9537292087646 0.020065600195303627 9.350966636154843e-11 10.02914349254469 -0.24261716952407375 ENFCNIHVSLVPQPSSTGEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENFCNIHVSLVPQPSSTGEQK 21 0 A0A3B3IRI2;P17812;B4E1E0;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 38010000.0 10499000.0 16412000.0 11099000.0 False True 13591162.46623018 15498657.772692528 9079095.885357073 1.0 1.1403482087129693 0.6680146682019149 23.69616552079823 -6.827085334024933 1.3407973937848683 1.0751594451357112 0.6560377344110518 0.8999273829317976 0.0626513453914554 0.18444153848653327 0.6494829778352159 0.03669768692534366 0.08447237164530352 1.489068463608602e-07 6.827085334024933 -0.4191217107246593 ENFIPCSEPVK(ub)GTGALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENFIPCSEPVKGTGALR 17 1 Q8NCD3;C9JWC4;Q8NCD3-3;Q8NCD3-2 Q8NCD3 HJURP Holliday junction recognition protein 1 29025200.0 6700500.0 4730700.0 17594000.0 True False 10165148.372165753 3886469.6238721916 14116538.188275864 1.0 0.38233279845812557 1.3887193449069393 23.277127937360294 -6.7406333048682585 1.6843751139769694 0.6327623340782369 1.38939221356885 0.607794243333676 0.2595137118826602 0.31666627697323646 1.7642954406312192 0.12187370317925801 0.29885975549075744 1.817049234853905e-07 6.7406333048682585 0.756629879490613 ENFIPCSEPVK(ub)GTGALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENFIPCSEPVKGTGALR 17 1 Q8NCD3;C9JWC4;Q8NCD3-3;Q8NCD3-2 Q8NCD3 HJURP Holliday junction recognition protein 1 39089700.0 6700500.0 5995200.0 26394000.0 True False 8673929.336601116 5661561.849795646 21590562.825309906 1.0 0.6527101651503806 2.4891328932326973 23.048254259452744 -6.857769168220698 1.1969265541930048 0.8125762029868474 2.574358852699821 0.9508737641580042 0.1765531319272925 0.14911812220487092 0.40721198982712 0.11514528195522887 0.268149394928012 1.387493099120399e-07 6.857769168220698 1.7617826497129738 up ENFQKPGNVK(ub)NSPGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENFQKPGNVKNSPGTK 16 2 H7C1U8;Q9BUR5;Q9BUR5-2;A0A0J9YWW6 H7C1U8 APOO Apolipoprotein O 1 2840270.0 788620.0 1079100.0 972550.0 True False 1033888.4570069427 918102.486298855 871919.8553583479 1.0 0.8880092238931824 0.8433403520941842 19.979649115515386 -13.999999999999998 0.1267986673860743 1.5322058622115124 0.7781648356782893 0.9996603332131804 0.0012144364944462495 11.94283906282471 0.11040581402085174 1.5889760477312822 0.05790263332586992 1.0000000000000041e-14 13.999999999999998 -0.7540410265332231 ENFQKPGNVK(ub)NSPGTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENFQKPGNVKNSPGTK 16 2 H7C1U8;Q9BUR5;Q9BUR5-2;A0A0J9YWW6 H7C1U8 APOO Apolipoprotein O 1 8432500.0 1789700.0 2563000.0 4079800.0 True False 2715105.7445959384 2105612.6251896 3273425.7417601338 1.0 0.7755177231607077 1.205634715434365 21.372576956758348 -6.764880294266074 1.594048944311033 0.8704015273194726 1.2075992988864146 0.7105799519247531 0.09449617321480663 0.27479901125356637 1.3771881327501572 0.04674937969237909 0.11181384164152658 1.7183819640426374e-07 6.764880294266074 0.337197771566942 ENFQKPGNVK(ub)NSPGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENFQKPGNVKNSPGTK 16 2 H7C1U8;Q9BUR5;Q9BUR5-2;A0A0J9YWW6 H7C1U8 APOO Apolipoprotein O 1 2674760.0 788620.0 762540.0 1123600.0 True False 1080194.125654164 728848.461417427 858228.8212683827 1.0 0.6747384049844165 0.7945135053837111 20.042859177038277 -10.360607638816946 6.8621738585750585 1.0000108701692847 0.7346259555362256 0.8674653051395749 0.04889797997814959 8.132227702570232e-06 7.577710476409949e-07 0.04734720360147719 0.015781755176546418 4.359055125038939e-11 10.360607638816946 -0.26538491463305913 ENFQKPGNVK(ub)NSPGTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENFQKPGNVKNSPGTK 16 2 H7C1U8;Q9BUR5;Q9BUR5-2;A0A0J9YWW6 H7C1U8 APOO Apolipoprotein O 1 2281680.0 804030.0 934670.0 542980.0 True False 668586.5695683968 929634.7471925307 656514.6075441381 1.0 1.3904478335433097 0.9819440554541027 19.350754849117404 -6.6564708019184415 1.9860144258767485 1.2520599542576545 0.983675273840992 0.22052547972707615 0.16638633231985447 0.49282682906067093 3.733105792186667 0.06778502522550804 0.18431517489128102 2.205612417085099e-07 6.6564708019184415 -0.2683846804166625 ENFQKPGNVK(ub)NSPGTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENFQKPGNVKNSPGTK 16 2 H7C1U8;Q9BUR5;Q9BUR5-2;A0A0J9YWW6 H7C1U8 APOO Apolipoprotein O 1 7173300.0 1789700.0 2473300.0 2910300.0 True False 2316801.9302611817 2335658.6807945636 2380655.262199723 1.0 1.0081391293261122 1.0275609801185477 21.143703278850797 -6.956454673321663 0.48284918066662463 0.9995460923179748 1.0369676233388931 0.9996148825428606 0.00022681858619236784 0.08099330031077735 0.026006010926435754 0.00027544398101530084 0.0016019898836706222 1.1054658392111118e-07 6.956454673321663 0.037421531020918386 ENFQNWLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENFQNWLK 8 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 42896200.0 3057200.0 22047000.0 17792000.0 False True 4008018.805966917 18757673.5385329 15951054.512915235 1.0 4.6800363088634995 3.9797853466077022 21.934457847121656 -10.47518826501079 5.387836644124097 0.9950474062357071 4.329910827735619 0.9678979293877846 0.28587625823666707 0.016967605243714292 0.001652758323038985 0.2761577999025119 0.09226616560221608 3.348202643789821e-11 10.47518826501079 3.3348634214999118 ENFQNWLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENFQNWLK 8 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 34151000.0 12353000.0 4977000.0 16821000.0 False True 11960860.77669033 6964342.05471213 12415075.480816742 1.0 0.5822609413098796 1.0379750849547216 23.51181788264189 -6.665657744931504 1.9534281254881187 0.7323665061395337 1.0360786151399044 0.25979489568081904 0.17762632605294493 0.471089664313592 3.4615256552401203 0.07332622273803972 0.1969779088904356 2.1594455360671306e-07 6.665657744931504 0.3037121090003707 ENFQNWLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENFQNWLK 8 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 44001200.0 3057200.0 17819000.0 23125000.0 False True 4187529.4577235105 17031697.660446867 17663351.27432477 1.0 4.067242471341539 4.218084064279561 21.997667908644548 -10.2130447420545 0.6408570091823848 4.612193935554007e-13 4.196978855075746 0.9997766742139825 0.022158271991571082 1.5091825671081183 0.3134480984758268 2.801985010561929 0.02490548049363209 6.122873091748094e-11 10.2130447420545 4.196978855075285 ENFQNWLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENFQNWLK 8 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 17110000.0 12353000.0 2494700.0 2262300.0 False True 10272066.830688419 2481260.555940823 2735336.4703066484 1.0 0.24155416790396142 0.26628881172527674 23.292223158076165 -10.140402695352682 5.218307440410928 1.000024386053392 0.25392148981431734 0.9991763441089642 0.010097876057347258 2.8649475368391347e-06 4.7192456109813e-07 0.009777545238948459 0.0032590754832173534 7.237645451759604e-11 10.140402695352682 -0.7461028962390746 ENFQNWLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENFQNWLK 8 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 16293600.0 5236100.0 4525100.0 6532400.0 False True 6778234.668961585 4273274.207117407 5343570.228084207 1.0 0.6304405816289134 0.7883424651189944 22.692478154491685 -10.174382914912552 5.321229246825466 1.000011749259465 0.709391524625393 0.8187183462848349 0.06446317399616872 8.985739225343916e-06 1.3942021003431942e-06 0.06241872280640591 0.02080539994418997 6.692942363646315e-11 10.174382914912552 -0.2906202246340719 ENFSCLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENFSCLTR 8 0 P40925;P40925-3;A0A5K1VW95;P40925-2;B9A041;C9JF79;C9JRL4 P40925 MDH1 Malate dehydrogenase, cytoplasmic;Malate dehydrogenase 0 5448950.0 3016200.0 508950.0 1923800.0 False True 2920452.381984408 712176.3891391875 1419899.0672370994 1.0 0.24385824385716343 0.4861914804693022 21.477760431133152 -10.202397817878476 5.376539118459866 1.0000326901857208 0.3650248621656047 0.9015197721872654 0.09893212956985409 3.876884426147445e-05 5.751000554342443e-06 0.09579553969381027 0.03193020751901925 6.274833147927056e-11 10.202397817878476 -0.6350078280201161 ENFSLDWCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENFSLDWCK 9 0 P23919;H7BZ20 P23919 DTYMK Thymidylate kinase 0 5216400.0 904500.0 1926000.0 2385900.0 False True 1185808.2591904607 1638648.3074892003 2139029.955168865 1.0 1.3818830277062575 1.8038582026989416 20.1774393196142 -6.969839354619401 0.26199421247261 0.8843776829702525 2.313915626449649 0.9999811024591411 0.0014271936042634544 0.07635486505123963 0.009216470631276794 0.008696671325274945 0.03969614871378501 1.0719157331775847e-07 6.969839354619401 1.4295379434793967 ENFSLDWCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENFSLDWCK 9 0 P23919;H7BZ20 P23919 DTYMK Thymidylate kinase 0 3602100.0 904500.0 1028800.0 1668800.0 False True 1238918.0931934172 983344.2142133528 1274663.8100148418 1.0 0.7937120457081219 1.0288523648317114 20.240649381137093 -6.675017182326064 1.9200200240857308 0.8688954482700401 1.027916383454712 0.3012707295162689 0.08752733590607072 0.4496977591255605 3.200801712206195 0.03664193263516745 0.09724673551892342 2.1134054239009961e-07 6.675017182326064 0.15902093518467197 ENGTVTAANASTLNDGAAALVLMTADAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENGTVTAANASTLNDGAAALVLMTADAAK 29 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 7484100.0 1534400.0 1155100.0 4794600.0 False True 1485691.311888095 1616337.4537669225 3538750.425083164 1.0 1.0879362629594942 2.381888079150125 20.50270296173476 -6.920661829319623 0.8198096211286945 0.972125436280501 2.593754966796239 0.9943626907535741 0.047430991738680664 0.0977837969218723 0.10360982637821362 0.04101053743838403 0.12363292794075574 1.2004336771301827e-07 6.920661829319623 1.6216295305157382 up ENHMQGK(ub)LNEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENHMQGKLNEK 11 1 H7BYN4;Q02241-3;Q02241-2;Q02241;A0A2U3TZL8 H7BYN4 KIF23 Kinesin-like protein;Kinesin-like protein KIF23 1 2360380.0 924570.0 494460.0 941350.0 True False 1196874.0909993723 466942.86633472703 770033.9590666614 1.0 0.3901353282239041 0.6433708982903075 20.19083996066573 -10.336721483502451 5.812917322651941 1.0000673885150508 0.5167531132571251 0.8292182686721141 0.10338298856425614 9.030072741448542e-05 1.0303782358807543e-05 0.1001140245777646 0.03336671608254225 4.6055183444076434e-11 10.336721483502451 -0.4833142752579257 ENIEQFFTK(ub)FVDEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENIEQFFTKFVDEGK 15 1 Q96L50;G3V5H2;Q96L50-2 Q96L50 LRR1 Leucine-rich repeat protein 1 1 7319400.0 3254800.0 1768200.0 2296400.0 True False 2706510.4120881343 1758674.355639779 2776566.6226460612 1.0 0.6497940476360191 1.02588433070312 21.36800250751123 -11.797545275334107 17.07083749263537 0.9020700800235951 0.8540552702526125 0.0 0.17563953353499062 0.0 0.0 0.0 0.05103433042507805 1.5938767099105434e-12 11.797545275334107 -0.0480148097709826 ENIFAIQTLK(ub)DFQYIDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENIFAIQTLKDFQYIDR 17 1 F6PQP6;I3L2B2;O95208-3;O95208-2;E9PBC1;O95208 F6PQP6 EPN2 Epsin-2 1 16804900.0 5666600.0 6147100.0 4991200.0 True False 5486716.884740015 8601669.08670301 3683854.987209588 1.0 1.5677260677740612 0.6714133542146754 22.387511703812585 -6.735578951552568 1.703130074010394 1.3395274978142726 0.6714078581712348 0.5847682473427682 0.23857312009331202 0.32590497458909856 1.8544210647566528 0.11090237006256919 0.2734503304415486 1.8383197304368086e-07 6.735578951552568 -0.6681196396430378 ENIFAIQTLK(ub)DFQYIDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENIFAIQTLKDFQYIDR 17 1 F6PQP6;I3L2B2;O95208-3;O95208-2;E9PBC1;O95208 F6PQP6 EPN2 Epsin-2 1 28736200.0 10021000.0 11510000.0 7205200.0 True False 15202589.633232329 9455950.571959531 5781089.061848657 1.0 0.6219960414697476 0.3802700198663127 23.857813759775233 -8.519755248178186 0.16551757770638245 1.3881399410851025 1.8160447183168366e-12 0.9998533530977108 0.0030884085767716022 0.1631282023431328 0.041687246711348463 0.1663675611004075 0.14050107104687343 3.021654129782054e-09 8.519755248178186 -1.3881399410832864 down ENIFAIQTLK(ub)DFQYIDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENIFAIQTLKDFQYIDR 17 1 F6PQP6;I3L2B2;O95208-3;O95208-2;E9PBC1;O95208 F6PQP6 EPN2 Epsin-2 1 4644400.0 1198200.0 1544000.0 1902200.0 True False 1641206.9201374827 1475780.9746747834 1452939.53703873 1.0 0.8992046990340246 0.8852872353944367 20.64632571179362 -13.999999999999998 0.2789648997163258 1.816806299161474 0.8810545582420011 0.9996028768340423 0.0010185513442823827 15.342895433700534 0.16730251654128975 7.145466787495204 0.005532682870523739 1.0000000000000041e-14 13.999999999999998 -0.9357517409194729 ENIFAIQTLK(ub)DFQYIDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENIFAIQTLKDFQYIDR 17 1 F6PQP6;I3L2B2;O95208-3;O95208-2;E9PBC1;O95208 F6PQP6 EPN2 Epsin-2 1 14206500.0 5666600.0 5532400.0 3007500.0 True False 4712028.97294414 5502595.863104577 3636354.344891146 1.0 1.1677763219835382 0.771717314509444 22.16791697924686 -6.791600933696947 1.4898142505246894 1.0935747962022258 0.7673101757840889 0.8065088925368676 0.07139989444188118 0.23297025967164714 1.0214645469624228 0.03771857303415545 0.08821098797274 1.6158426470182202e-07 6.791600933696947 -0.32626462041813686 ENIFAIQTLK(ub)DFQYIDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENIFAIQTLKDFQYIDR 17 1 F6PQP6;I3L2B2;O95208-3;O95208-2;E9PBC1;O95208 F6PQP6 EPN2 Epsin-2 1 25587600.0 10021000.0 10858000.0 4708600.0 True False 12972382.043441528 10253742.7550509 3851683.1143159117 1.0 0.7904286753746127 0.29691409807524244 23.628940081867682 -6.956730458005952 0.47930028982735584 1.0119241012346034 0.05486723549716908 0.9996290422089045 0.00567662787232191 0.08089048925193534 0.025609364596648625 0.006948564998945543 0.04071178116892866 1.1047640716742277e-07 6.956730458005952 -0.9570568657374343 down ENIIDESGMPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENIIDESGMPK 11 0 A0A1B0GX30;A0A087X0M5 A0A1B0GX30 TRBV18 0 3214460.0 828240.0 1429700.0 956520.0 False True 1085830.6606875688 1216394.3329269509 857548.4859877293 1.0 1.1202431253476548 0.7897626370623142 20.050367696374906 -6.808238106152582 1.4217656238637462 1.0656694034046807 0.7842020915620619 0.855221121778142 0.0519666858266324 0.20921007616056378 0.8338016749048618 0.028741849273105576 0.06654541281890854 1.5551127921998033e-07 6.808238106152582 -0.28146731184261886 ENIIDESGMPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENIIDESGMPK 11 0 A0A1B0GX30;A0A087X0M5 A0A1B0GX30 TRBV18 0 3085100.0 1394200.0 904280.0 786620.0 False True 1349941.884146496 1265363.7197579024 580580.6239058364 1.0 0.937346810716916 0.43007823575524506 20.36446586900148 -6.929873412236605 0.7478309508961116 1.007750337620975 0.32627369712237264 0.9965132984618505 0.01506802279663046 0.09270362278610123 0.07800269334458693 0.013717365548837216 0.04593105473996905 1.175240062932387e-07 6.929873412236605 -0.6814766404986025 down ENIIDESGMPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENIIDESGMPK 11 0 A0A1B0GX30;A0A087X0M5 A0A1B0GX30 TRBV18 0 5805300.0 1465600.0 1596000.0 2743700.0 False True 2223422.349712133 1311181.330395085 2201406.4923935696 1.0 0.5897131197610045 0.9900982117403768 21.084350590545466 -10.8046345055428 10.150138172850625 1.0021848799345467 0.7899056662677288 0.2685369323500647 0.1634565293277953 0.008144571429314261 0.0001567627839787702 0.15949688703752476 0.052755367992951295 1.568070174735792e-11 10.8046345055428 -0.2122792136668179 ENIIDESGMPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENIIDESGMPK 11 0 A0A1B0GX30;A0A087X0M5 A0A1B0GX30 TRBV18 0 2916440.0 828240.0 1010200.0 1078000.0 False True 1134462.7103444054 965566.0237153261 823398.6021069025 1.0 0.8511218702130766 0.7258049071149562 20.113577757897797 -6.973115475288059 0.16783146956495845 1.1140070929246177 0.45957055166656047 0.9999976009510334 0.00017349904100336886 0.07530411473247102 0.005222994627418392 0.005387956181073248 0.014625861690951144 1.0638601090660084e-07 6.973115475288059 -0.6544365412580573 ENIIDESGMPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENIIDESGMPK 11 0 A0A1B0GX30;A0A087X0M5 A0A1B0GX30 TRBV18 0 3156340.0 1394200.0 980330.0 781810.0 False True 1159339.0735324048 975048.7677097298 945282.8563189851 1.0 0.8410384761197097 0.8153635790423166 20.144871144435758 -13.999999999959005 0.25658135234536594 2.143228677872148 0.8056676881834617 0.999555434497456 0.0017218171216917834 14.268532366974709 0.1602842989564605 8.44053305098566 0.011430453554377223 1.000000000094394e-14 13.999999999959005 -1.3375609896886862 ENIIDESGMPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENIIDESGMPK 11 0 A0A1B0GX30;A0A087X0M5 A0A1B0GX30 TRBV18 0 5950300.0 1465600.0 1274300.0 3210400.0 False True 1897248.0912950693 1203384.084800272 2626140.141485751 1.0 0.6342787168012577 1.3841838363337802 20.855476912637915 -6.77408282764417 1.5586915734914941 0.7913272574097648 1.3890815201914677 0.7459663160594969 0.15431928962720903 0.25988437919116963 1.246574334678243 0.07801102300331393 0.18502215112657236 1.6823531759459964e-07 6.77408282764417 0.5977542627817028 ENIK(ub)LIGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENIKLIGGK 9 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34 1 26735200.0 11836000.0 10280000.0 4619200.0 True False 15517110.619987046 8746264.07112614 4141249.4944951693 1.0 0.563652878768576 0.2668827719228199 23.88735660818688 -8.221881117395073 0.2397940163682963 1.2149371674525906 2.532139163059494e-12 0.9995643888227731 0.006284273812275278 0.08908485808654597 0.052078944199583775 0.09595563021176286 0.10593332494204148 5.999552839274957e-09 8.221881117395073 -1.2149371674500584 down ENIK(ub)LIGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENIKLIGGK 9 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34 1 26548000.0 8474100.0 9399100.0 8674800.0 True False 8205094.33398783 13152209.645658994 6402609.641578322 1.0 1.6029321675411832 0.7803212712688622 22.96808848982661 -6.710223882048255 1.7943439541163708 1.3705694747515191 0.7822308350857116 0.4662966216983315 0.25406092590568524 0.37457242741216695 2.3510170040754677 0.11266934186985282 0.286162138005613 1.9488396993466608e-07 6.710223882048255 -0.5883386396658076 ENIK(ub)LIGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENIKLIGGK 9 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34 1 26458300.0 11836000.0 9213800.0 5408500.0 True False 16212089.055873165 8806703.850037903 4131123.691553977 1.0 0.543218324281749 0.2548174807895835 23.950566669709772 -8.451707870660984 0.23388316498481423 1.2527538118687125 6.075641599201988e-22 0.9995067938559845 0.006813428283919358 0.14164116986059522 0.05903286982829866 0.13132970319920906 0.11381329721995664 3.5342081930985395e-09 8.451707870660984 -1.2527538118687125 down ENIK(ub)LIGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENIKLIGGK 9 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34 1 27296000.0 8474100.0 12819000.0 6002900.0 True False 7046589.61628243 12749941.50262771 7258078.63572636 1.0 1.8093776134155233 1.030012961015247 22.748493765260886 -10.208113047043582 3.955296758981253 0.9997273399408797 1.4196952867154384 0.2788409528646201 0.3181742880202196 35350715.45636215 18247312.02540297 89364.8659602801 0.1089195199494799 6.192798552777227e-11 10.208113047043582 0.41996794677455873 ENIQK(ub)SLAGSSGPGASSGTSGDHGELVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENIQKSLAGSSGPGASSGTSGDHGELVVR 29 1 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7 E9PI39;P29692 EEF1D Elongation factor 1-delta 1 159555100.0 49779000.0 54106600.0 55669500.0 True False 65260751.06052168 46034106.18587497 49909354.15955126 1.0 0.7053873183773773 0.7647683078802786 25.959712255151196 -10.74419848168137 6.910751199838516 1.0045220741613268 0.7350778131288371 0.9636875353101959 0.02424218745061204 0.001709023317089337 6.325944714960072e-05 0.02375028496439183 0.00782413235598824 1.8021939122272017e-11 10.74419848168137 -0.26944426103248964 ENIQK(ub)SLAGSSGPGASSGTSGDHGELVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENIQKSLAGSSGPGASSGTSGDHGELVVR 29 1 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7 E9PI39;P29692 EEF1D Elongation factor 1-delta 1 139760000.0 67588100.0 13236000.0 58935900.0 True False 65442552.76135552 18521203.824828148 43498819.75089873 1.0 0.2830146906458255 0.6646870868488678 25.963725689757663 -10.714757278067053 6.855115079303657 1.0058309209908571 0.4738508887490235 0.7170197140118275 0.1558171032671382 0.013921580330571667 0.0005792790087960285 0.15125871590973583 0.050289753833992284 1.928602484643409e-11 10.714757278067053 -0.5319800322418337 ENIQK(ub)SLAGSSGPGASSGTSGDHGELVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENIQKSLAGSSGPGASSGTSGDHGELVVR 29 1 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7 E9PI39;P29692 EEF1D Elongation factor 1-delta 1 377183000.0 100650000.0 163869000.0 112664000.0 True False 152693408.50063193 134625296.63565925 90395911.01761454 1.0 0.8816706494249363 0.592009255050721 27.186062544031948 -6.9559114175303645 0.4896702519120787 1.0063580051264986 0.4550458804366061 0.999587213184444 0.003482094691526462 0.0811953499532009 0.02678423678134129 0.004167555899958425 0.02389040338262719 1.1068495235847149e-07 6.9559114175303645 -0.5513121246898925 ENIQK(ub)SLAGSSGPGASSGTSGDHGELVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENIQKSLAGSSGPGASSGTSGDHGELVVR 29 1 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7 E9PI39;P29692 EEF1D Elongation factor 1-delta 1 132836300.0 49779000.0 39491100.0 43566200.0 True False 68183641.52689333 37746252.6223959 33276760.834053513 1.0 0.5535969006217986 0.4880461073779453 26.022922316674087 -13.999999999999927 0.27016219113434803 4.44850372244723 0.46632160753791807 0.9995836766623966 0.004641225269600651 14.890930210213105 0.1645396115644089 28.206524114741576 0.027202518744746832 1.0000000000001677e-14 13.999999999999927 -3.9821821149093117 ENIQK(ub)SLAGSSGPGASSGTSGDHGELVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENIQKSLAGSSGPGASSGTSGDHGELVVR 29 1 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7 E9PI39;P29692 EEF1D Elongation factor 1-delta 1 188274100.0 67588100.0 93523000.0 27163000.0 True False 56202499.81051184 93019173.03613797 32842657.712478213 1.0 1.6550718090788572 0.5843629344461202 25.74413096519194 -6.741139558681583 1.6824722611869052 1.3892533342871807 0.5835744444461385 0.610045366825557 0.2752280012063624 0.31577081452396255 1.7555151225767431 0.12938779791757368 0.31711609402093494 1.8149323482771763e-07 6.741139558681583 -0.8056788898410422 ENIQK(ub)SLAGSSGPGASSGTSGDHGELVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENIQKSLAGSSGPGASSGTSGDHGELVVR 29 1 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7 E9PI39;P29692 EEF1D Elongation factor 1-delta 1 403556000.0 100650000.0 192478000.0 110428000.0 True False 130293409.10811181 181766430.09823996 90331237.08696389 1.0 1.3950546796071477 0.693290917056372 26.957188866124397 -6.7539624650553876 1.6350497832787327 1.2311901853908223 0.6914556976377818 0.6658403024119748 0.16604908253900855 0.2932125140540245 1.543377397492996 0.08018303108694833 0.19386985561719908 1.7621283360080115e-07 6.7539624650553876 -0.5397344877530404 ENK(ub)ITITNDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENKITITNDK 10 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 70979000.0 25987000.0 27298000.0 17694000.0 True False 34069208.658465944 23225244.806770597 15863194.612832861 1.0 0.6817077860421421 0.46561676180556005 25.021965101878678 -8.138434300869335 0.13973886560627216 1.3979797711161566 2.4210079079836824e-09 0.9999528835484554 0.0015065786603631094 0.08913009205569138 0.026448480717865964 0.11454882232176063 0.12593415506270283 7.2705237780772395e-09 8.138434300869335 -1.3979797686951487 down ENK(ub)ITITNDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENKITITNDK 10 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 77084000.0 25445000.0 29083000.0 22556000.0 True False 24637262.40288883 40695993.56584146 16647906.934504613 1.0 1.6518066374561837 0.6757206487581416 24.554338622468553 -6.726743923269936 1.7352998006058515 1.3936727606850765 0.6766576559807612 0.5440356816773515 0.27408076490873445 0.34236720625831824 2.0182340523935998 0.12524880405045596 0.3119252453208858 1.8761004029511545e-07 6.726743923269936 -0.7170151047043153 ENK(ub)ITITNDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENKITITNDK 10 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 133104000.0 63523000.0 48168000.0 21413000.0 True False 96369035.15335956 39572044.061698295 17180711.164348695 1.0 0.4106302817987564 0.17828041068386427 26.52206632511746 -10.443340984493041 0.20682173775720938 1.7664585707679747 3.3788394609278373e-16 0.9993495366233146 0.008820850254438859 2.135403857241146 0.10421148078591427 0.9837838019217511 0.13421983523926065 3.602956473216575e-11 10.443340984493041 -1.7664585707679743 ENK(ub)ITITNDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENKITITNDK 10 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 68743000.0 25987000.0 18026000.0 24730000.0 True False 35595096.172268964 17229551.7159894 18889283.330337364 1.0 0.484042847717108 0.5306709452032164 25.08517516340157 -10.138082412826789 8.034170759798902 1.000000058578653 0.5073568974060608 0.9933260384568805 0.019035841086286146 1.99794778301217e-08 2.15366136397261e-09 0.01843137607422854 0.0061437912923531035 7.276417122906538e-11 10.138082412826789 -0.4926431611725922 ENK(ub)ITITNDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENKITITNDK 10 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 83815000.0 25445000.0 43559000.0 14811000.0 True False 21158644.904627785 43324339.02121543 17907911.621673394 1.0 2.0475951657820772 0.8463638244506199 24.33474389790283 -6.67617753712798 1.9151526734461104 1.665066766735916 0.8510252696719616 0.3068820119556286 0.4443679552588287 0.447055906895468 3.1667164205094984 0.18639716234107925 0.4940876568907982 2.1077663308366677e-07 6.67617753712798 -0.8140414970639545 ENK(ub)ITITNDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENKITITNDK 10 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 128737000.0 63523000.0 53013000.0 12201000.0 True False 82231775.72552991 50062779.947827704 9980543.192831947 1.0 0.6088009106713851 0.12137088254234742 26.29319264720991 -7.590470749562153 0.4764934799392575 1.0205033640698515 2.1592835217623752e-20 0.9970767892001102 0.01943240468941383 0.1182657934727874 0.07384410598191155 0.02434725309006607 0.07207596162923449 2.5676111350576078e-08 7.590470749562153 -1.0205033640698515 down ENK(ub)ITITNDK(ub)GR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENKITITNDKGR 12 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 2 20666200.0 6872600.0 9982900.0 3810700.0 True False 9010045.154353062 8493490.233039422 3416405.3188155442 1.0 0.942668997495082 0.3791773803891495 23.103102905529248 -6.92647949428645 0.7751462027985755 1.0097795192999726 0.273226449196927 0.9957998992817939 0.01815439460561978 0.09450752753658057 0.08694123610934791 0.016205419911776018 0.05200814913815023 1.1844602913320801e-07 6.92647949428645 -0.7365530701030456 down ENK(ub)ITITNDK(ub)GR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENKITITNDKGR 12 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 2 23365900.0 7460300.0 10138000.0 5767600.0 True False 7223476.860061767 14186156.26897158 4256892.535708858 1.0 1.963895855665588 0.5893135145548812 22.784261982806903 -6.718212564996678 1.765641380763068 1.587537219386552 0.5916547933586135 0.5041060426734469 0.40570266832099633 0.35880747315966094 2.185066727062533 0.18251058039971396 0.4591541478655795 1.9133192236393958e-07 6.718212564996678 -0.9958824260279385 ENK(ub)ITITNDK(ub)GR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENKITITNDKGR 12 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 2 29582900.0 15012000.0 9380700.0 5190200.0 True False 22774301.524207525 7706640.793256372 4164354.695054523 1.0 0.33839197154146483 0.18285323440668858 24.44090347222286 -13.999999999999861 0.20338850762517854 4.726164193061654 0.08514613752144334 0.9994873883894847 0.008021287779948745 12.599965430049533 0.14298461095842993 18.70440872732958 0.09659400460842624 1.000000000000319e-14 13.999999999999861 -4.6410180555402105 ENK(ub)ITITNDK(ub)GR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENKITITNDKGR 12 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 2 18322400.0 6872600.0 6604200.0 4845600.0 True False 9413585.94503158 6312404.60683109 3701169.07826457 1.0 0.6705632310249134 0.3931731329460076 23.16631296705214 -7.404986511059382 0.20984121854555485 1.1757937349666445 9.11435722624603e-14 0.999957197960804 0.00162274570504794 0.12019545987358085 0.016457885850325153 0.024587878952839273 0.056932478599843926 3.9356229908803753e-08 7.404986511059382 -1.1757937349665535 down ENK(ub)ITITNDK(ub)GR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENKITITNDKGR 12 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 2 22919300.0 7460300.0 11643000.0 3816000.0 True False 6203569.997327363 11580276.84804545 4613907.9568095105 1.0 1.8667117245448173 0.7437504467262053 22.56466725824118 -6.700567511677375 1.8286242258004242 1.5378808682730345 0.7470285332771004 0.4203972446892389 0.36581016822893125 0.39432997274456844 2.563864281113495 0.159561652304995 0.41009699637983255 1.9926567208461047e-07 6.700567511677375 -0.7908523349959341 ENK(ub)ITITNDK(ub)GR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENKITITNDKGR 12 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 2 29513800.0 15012000.0 12516000.0 1985800.0 True False 19433329.930759817 11819473.597551784 1624404.7760286578 1.0 0.6082062950438293 0.08358859659236721 24.21202979431531 -7.602586040941822 0.5317954087493452 1.0111864737554959 1.836698822241662e-23 0.9952105327193392 0.025982068335220317 0.11749859908203988 0.09136037199958308 0.02786653261338435 0.07342992391682941 2.4969736482429948e-08 7.602586040941822 -1.0111864737554959 down ENK(ub)ITITNDKGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENKITITNDKGR 12 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 11167000.0 3161800.0 5332700.0 2672500.0 True False 4093012.42839571 5035930.5571799595 2186132.4221656714 1.0 1.230372652240842 0.5341133115060058 21.96473161684244 -6.817552344225347 1.3826136790141508 1.1244835851505508 0.5197186862591795 0.8786180965526461 0.10090208758576026 0.19668381836007306 0.7394706511473896 0.0573609366610465 0.1322901046038287 1.5221156657392104e-07 6.817552344225347 -0.6047648988913713 ENK(ub)TAVVVGTITDDVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENKTAVVVGTITDDVR 16 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 44251000.0 8898000.0 18117000.0 17236000.0 True False 11665364.168354588 15414014.219512897 15452584.059386648 1.0 1.3213487377725868 1.3246550931779657 23.475728010168748 ENK(ub)TAVVVGTITDDVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENKTAVVVGTITDDVR 16 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 94078000.0 27743000.0 25036000.0 41299000.0 True False 26862313.650750395 35033005.36101525 30481552.956557304 1.0 1.3041693212467054 1.1347329702445719 24.679080233634878 -10.212886356195206 3.988198279499345 0.9998430320444236 1.2194511457878283 0.6910401603514306 0.06917210078597534 9386662.055141961 8061768.86016205 11402.752775172972 0.023679450949300615 6.125106491929661e-11 10.212886356195206 0.21960811374340472 ENK(ub)TAVVVGTITDDVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENKTAVVVGTITDDVR 16 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 223032000.0 85650000.0 48761000.0 88621000.0 True False 129937311.85374203 40059218.578568116 71105020.50603591 1.0 0.3082965008823558 0.5472255774082199 26.95324052319461 -10.20912180293537 5.394731690509991 1.0000306980686193 0.4277610391458736 0.8843681390455899 0.09754238703420631 3.6340486983659874e-05 5.327473927266388e-06 0.09445010814908138 0.03148167004433945 6.178430945595469e-11 10.20912180293537 -0.5722696589227457 ENK(ub)TAVVVGTITDDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENKTAVVVGTITDDVR 16 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 47430000.0 8898000.0 18845000.0 19687000.0 True False 12187831.059408547 18012365.587918583 15037336.06649219 1.0 1.4778975438795334 1.233799188156939 23.53893807169164 -10.018386696406319 4.221309421232074 0.9999751756511962 1.3558483658704097 0.7391487719357162 0.09965273686821102 15290310.491698643 33829480.60122899 5437.23443503926 0.03646916362069245 9.585467600695538e-11 10.018386696406319 0.3558731902192135 ENK(ub)TAVVVGTITDDVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENKTAVVVGTITDDVR 16 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 78958000.0 27743000.0 27937000.0 23278000.0 True False 23069533.72328897 27786497.835939694 28145322.17468864 1.0 1.2044672497168374 1.2200212848808298 24.459485509069154 -12.70528700795761 0.3840838866285931 8.977570510658333e-11 1.2213577797424469 0.999765901652681 0.001533905816709158 9.125551275271437 0.20015508589567205 7.304866186414189 0.004164991454357508 1.9711196709620908e-13 12.70528700795761 1.2213577796526711 ENK(ub)TAVVVGTITDDVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENKTAVVVGTITDDVR 16 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 230552000.0 85650000.0 97363000.0 47539000.0 True False 110875613.41390747 91944663.46104443 38887389.791331604 1.0 0.8292595696206676 0.35072987281848794 26.724366845287058 -6.952969360570068 0.5252333173874971 1.0078148791755912 0.15062753626825612 0.9994141837196294 0.00665144846080057 0.08231483930304237 0.031193786897622915 0.0074739812671659875 0.03954885875455256 1.114373149726796e-07 6.952969360570068 -0.8571873429073351 down ENLATVEGNFASIDER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENLATVEGNFASIDER 16 0 Q13561;Q13561-3;Q13561-2;H0YI98 Q13561 DCTN2 Dynactin subunit 2 0 7870800.0 2071600.0 3186800.0 2612400.0 False True 2715887.661402939 2711341.862049109 2342093.9079102855 1.0 0.9983262196671707 0.8623677411975267 21.372992375236446 -6.909586573152765 0.8985444228514832 1.004264780152353 0.8449518128936411 0.9907646418616105 0.0061974952412104534 0.10469206374446736 0.1402544348056276 0.005063624299876858 0.013938200639510515 1.23144048339604e-07 6.909586573152765 -0.1593129672587119 ENLATVEGNFASIDER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENLATVEGNFASIDER 16 0 Q13561;Q13561-3;Q13561-2;H0YI98 Q13561 DCTN2 Dynactin subunit 2 0 8328800.0 2285800.0 1138300.0 4904700.0 False True 2213238.5301836636 1592829.126156082 3620011.932153969 1.0 0.7196825396058428 1.635617617705926 21.07772751425814 -6.824559684445731 1.3520025485649563 0.8495670828832634 1.6576429096619012 0.8945594737885912 0.12442858714691842 0.1876197324262262 0.6725957589675625 0.07229711073375052 0.1664680642226969 1.497753404874193e-07 6.824559684445731 0.8080758267786378 ENLATVEGNFASIDER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENLATVEGNFASIDER 16 0 Q13561;Q13561-3;Q13561-2;H0YI98 Q13561 DCTN2 Dynactin subunit 2 0 8662500.0 2071600.0 3570100.0 3020800.0 False True 2837526.502885001 3412361.1772580603 2307349.2553288783 1.0 1.2025830150973418 0.813155138104587 21.436202436759338 -6.765317367212701 1.5922138711699505 1.1168894909294167 0.8113336720465801 0.7123838716227896 0.08528569948054987 0.274073405335292 1.370442562193033 0.04223810934435077 0.1009889994634454 1.7166534583976281e-07 6.765317367212701 -0.30555581888283656 ENLAYGK(ub)GVLSGEECKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENLAYGKGVLSGEECKK 17 2 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BT54;H3BMG4;Q9NVI1-4 Q9NVI1 FANCI Fanconi anemia group I protein 1 3912300.0 770400.0 1459300.0 1682600.0 True False 1010001.8605642137 1241578.1283068487 1508500.6926388922 1.0 1.2292830110365047 1.4935622908617256 19.945926519949058 -6.96926499301874 0.2751743202643351 0.9382893597613435 1.7925564490244716 0.9999760683481929 0.0009865267166958153 0.07654192996891276 0.009880625972841188 0.005021323792811077 0.02440887264181847 1.0733342972084694e-07 6.96926499301874 0.8542670892631281 ENLAYGK(ub)GVLSGEECKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENLAYGKGVLSGEECKK 17 2 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BT54;H3BMG4;Q9NVI1-4 Q9NVI1 FANCI Fanconi anemia group I protein 1 34597400.0 2282900.0 9798500.0 22516000.0 True False 3463326.2023456786 8049881.118970065 18065702.730886597 1.0 2.324320797018183 5.2162867935024035 21.72372684722689 -6.958290082750702 0.4588968813152841 0.9147693711255886 6.7422036338146 0.9997014311064217 0.03042000449086218 0.08031767252362099 0.023431606375717666 0.03920307247496729 0.23893481511031606 1.100803792803364e-07 6.958290082750702 5.827434262689011 ENLAYGK(ub)GVLSGEECKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENLAYGKGVLSGEECKK 17 2 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BT54;H3BMG4;Q9NVI1-4 Q9NVI1 FANCI Fanconi anemia group I protein 1 49282200.0 2282900.0 4951300.0 42048000.0 True False 2955259.052686621 4675755.802457496 34395695.448913805 1.0 1.5821813651858283 11.638808928660497 21.494853169319338 -6.918795160745276 0.8336186324170292 0.7683253864554107 13.216399933728546 0.9938395553397977 0.3833180537292618 0.09888582634059521 0.10932747510013884 0.3281778446376891 0.9719995096028033 1.2056044414587828e-07 6.918795160745276 12.448074547273135 up ENLESWLNYLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENLESWLNYLK 11 0 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 3948700.0 1518600.0 537600.0 1892500.0 False True 1470392.8742396124 752266.4835469631 1396797.4762169719 1.0 0.5116091737971624 0.9499484802245801 20.48777024954847 -10.357318502579888 8.507482209956379 1.0000009172924231 0.7307788270108714 0.3346477749431198 0.17895127249210868 3.1133204614623063e-06 2.3550718767407542e-07 0.1732694131561724 0.05775627484538022 4.392193828926375e-11 10.357318502579888 -0.26922209028155175 ENLESWLNYLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENLESWLNYLK 11 0 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 3001790.0 307270.0 691920.0 2002600.0 False True 420876.02265952615 661348.6865265379 1529627.1248416349 1.0 1.5713622323919973 3.6343888520326786 18.683035796005704 -6.947229021577479 0.588479298645222 0.9760443924667056 4.333244520739571 0.9989655011973486 0.036392996474242406 0.08461788256659435 0.040717075287949545 0.03778933357248295 0.17275209227635768 1.1292002832725151e-07 6.947229021577479 3.3572001282728654 ENLISALEEAK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENLISALEEAKK 12 1 P22102;P22102-2 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 18289300.0 4619200.0 4378700.0 9291400.0 True False 6055815.932396428 3725415.0280389152 8330015.0574022485 1.0 0.6151796999161236 1.375539671349599 22.529889924341578 -6.769110791169339 1.5777989648722404 0.7790262736450854 1.3796788723837483 0.727163239744459 0.16214585281481483 0.267873032736948 1.3159211062335896 0.08100909186620621 0.1929975858311829 1.7017243327676567e-07 6.769110791169339 0.600652598738663 ENLISALEEAK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENLISALEEAKK 12 1 P22102;P22102-2 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 28262000.0 6684200.0 7318800.0 14259000.0 True False 6472013.729746105 10241235.007037807 10524140.139169235 1.0 1.5823877134203124 1.6260997857280648 22.625783237632177 -11.47077669878925 0.43034820873356017 6.8465688230687205e-09 1.6273714611018177 0.99972885491348 0.004699558784451554 3.9390471912292413 0.21379019747437092 3.6880953746116543 0.010324140677810793 3.382387037109398e-12 11.47077669878925 1.6273714542552489 ENLISALEEAK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENLISALEEAKK 12 1 P22102;P22102-2 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 17793100.0 4619200.0 5377000.0 7796900.0 True False 6327043.06918632 5139426.360638797 5955432.802196018 1.0 0.8122951439462457 0.9412663604583157 22.59309998586447 -10.098508925480635 4.666558245274908 1.0000076527573145 0.8767807521999131 0.5489512216841198 0.0526522786682035 4.19235449679801e-06 8.099780672577242e-07 0.05098351571733435 0.01699344986733908 7.970601094987264e-11 10.098508925480635 -0.12322690055740138 ENLISALEEAK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENLISALEEAKK 12 1 P22102;P22102-2 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 26234500.0 6684200.0 5699300.0 13851000.0 True False 5558208.460267761 5668596.739677523 16747180.060211897 1.0 1.019860406495881 3.0130536088970508 22.406188513066454 -6.90907966278878 0.9019786799815944 0.9364761396539946 3.2656338501099897 0.9905696197965526 0.09170268629932518 0.10502977791831637 0.14209146785216828 0.07473824017507759 0.20501940712466288 1.2328786651215556e-07 6.90907966278878 2.3291577104559953 up ENLK(ub)AAQEEYVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENLKAAQEEYVK 12 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 315293000.0 109207000.0 145999000.0 60087000.0 True False 143171434.56209233 124216518.29964478 53869773.63520342 1.0 0.8676068566301405 0.37626062629022916 27.093168435174885 -6.946597545083932 0.5950268077185944 1.0056004610657554 0.2133287487271349 0.9989065021595117 0.008873093895427578 0.08488145289319153 0.04184340024042063 0.009152067073533247 0.04122596747363589 1.1308433667647231e-07 6.946597545083932 -0.7922717123386205 down ENLK(ub)AAQEEYVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENLKAAQEEYVK 12 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 430219000.0 103612000.0 130241000.0 196366000.0 True False 100322893.77434143 182246910.4978427 144931853.7462731 1.0 1.8166034056770215 1.4446538401520954 26.58007562692167 -10.198016588871543 6.0266906484664196 0.9999907431035746 1.6306286229145626 0.7930813049363091 0.15184777426434226 1.8887057140535146e-05 2.5131277548120685e-06 0.14702812858934575 0.049008658407036235 6.338454996152189e-11 10.198016588871543 0.630637879810988 ENLK(ub)AAQEEYVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENLKAAQEEYVK 12 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 365580000.0 125788000.0 127017000.0 112775000.0 True False 190829592.33459997 104349823.9616495 90484971.8189616 1.0 0.5468220242208707 0.4741663528804566 27.5077096694569 -13.999999999999998 0.25763549346011094 4.2769855252124085 0.4470035589255964 0.9995575468861779 0.004893769285156308 14.31395468674714 0.16061748514457636 24.38634771204372 0.03216484091411912 1.0000000000000041e-14 13.999999999999998 -3.829981966286812 ENLK(ub)AAQEEYVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENLKAAQEEYVK 12 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 268095000.0 109207000.0 89769000.0 69119000.0 True False 149583779.10820717 85802708.75361432 52794515.750488885 1.0 0.5736097140021155 0.35294278607774676 27.156378496697776 -10.321702862195952 0.14017245437282128 1.8028021652911608 4.298505327123353e-15 0.9997603354512705 0.004157810263080019 2.0376236634612006 0.07057324168614233 0.7880603504397431 0.21534402466119773 4.767570653136685e-11 10.321702862195952 -1.8028021652911566 ENLK(ub)AAQEEYVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENLKAAQEEYVK 12 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 431653000.0 103612000.0 238799000.0 89242000.0 True False 86157968.78987205 237512542.38910973 107902089.59161295 1.0 2.7567100957123487 1.2523750397919888 26.360480902355945 -6.6083860433787045 2.159514629195117 2.174921113429828 1.2576572744163785 0.045446295961464434 0.7576834693497888 0.617116296683643 5.45111344536567 0.2899628536988524 0.8414794551151656 2.463848254436247e-07 6.6083860433787045 -0.9172638390134495 ENLK(ub)AAQEEYVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENLKAAQEEYVK 12 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 346442000.0 125788000.0 162495000.0 58159000.0 True False 162835045.65217257 153452010.40541518 47574658.76173368 1.0 0.942377052745757 0.29216473991327757 27.27883599154935 -6.924301645118787 0.7921751109962707 1.0122472075149842 0.17618714786113238 0.9952946458186419 0.02201631112866977 0.09570661150263086 0.09298163261548999 0.019415032107086335 0.06078026227841863 1.1904149020168292e-07 6.924301645118787 -0.8360600596538519 down ENLK(ub)AAQEEYVK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENLKAAQEEYVKR 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 2 8738200.0 2280600.0 3299900.0 3157700.0 True False 2989888.6853618133 2807567.782909452 2830971.4947972386 1.0 0.9390208393559982 0.946848459160832 21.511660342688717 -10.814408054246863 6.951546753572996 1.0029256434892644 0.9429346492583752 0.9860847381486252 0.0031956124037244836 0.00015201193026725043 4.058402844781081e-06 0.00324607566509223 0.0010313794683798933 1.5331757651240123e-11 10.814408054246863 -0.05999099423088916 ENLK(ub)AAQEEYVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENLKAAQEEYVKR 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 2 16108000.0 3912300.0 4574200.0 7621500.0 True False 3788106.1779847504 6400701.91413788 5625200.509901006 1.0 1.6896838719402039 1.4849637907703999 21.853045338437028 -10.225259326657177 4.689470327496595 0.9998633044980535 1.5873238313578704 0.9164871527248455 0.08357662316999843 0.00011947162468865503 1.9737819977980868e-05 0.0809413713192899 0.026974239137892212 5.953065669120213e-11 10.225259326657177 0.5874605268598169 ENLK(ub)AAQEEYVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENLKAAQEEYVKR 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 2 32729600.0 7629500.0 8575100.0 16525000.0 True False 11574509.291163158 7044806.407437901 13258826.506835215 1.0 0.6086483867455557 1.145519535498407 23.46444769500054 -6.711240872675124 1.7905847210801957 0.7597111778912459 1.1443149455982076 0.47104482787570157 0.16488208123650103 0.3726066301252128 2.329481217568473 0.07325428101294845 0.18583451310881194 1.944281426044191e-07 6.711240872675124 0.3846037677069617 ENLK(ub)AAQEEYVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENLKAAQEEYVKR 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 2 10035100.0 2280600.0 3091200.0 4663300.0 True False 3123799.4508976256 2954620.5627685823 3561924.583678216 1.0 0.9458419495910886 1.1402539246412553 21.57487040421161 -6.832361887290179 1.3171905765576717 0.9711038808872106 1.1457469520312071 0.910528100992644 0.024504255703524127 0.17792449943016173 0.6028712990474872 0.01460228450927986 0.033605997496561055 1.4710861703557955e-07 6.832361887290179 0.17464307114399658 ENLK(ub)AAQEEYVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENLKAAQEEYVKR 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 2 18739700.0 3912300.0 9056900.0 5770500.0 True False 3253250.7942768834 9008108.682046112 6977084.870222553 1.0 2.7689561154932076 2.144650170376239 21.633450613871304 -10.211896703082841 5.33905986555549 0.9999097036516964 2.4568031429349864 0.8789368087172126 0.25487183482135123 0.00027395829882824067 4.0439518569603135e-05 0.2467935770198863 0.08225953097323514 6.139080057843115e-11 10.211896703082841 1.45689343928329 ENLK(ub)AAQEEYVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENLKAAQEEYVKR 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 2 26964000.0 7629500.0 14224000.0 5110500.0 True False 9876538.149928859 13432421.896099113 4180441.4381581573 1.0 1.3600334137519499 0.4232699124630293 23.23557401709299 -6.802495264257843 1.445537207578038 1.198019936383829 0.4095011053463529 0.839418264041004 0.15461140978567706 0.2172041325000513 0.8957371509075113 0.08413061731360467 0.1953816793635201 1.5758132060254415e-07 6.802495264257843 -0.7885188310374762 down ENLK(ub)AAQEEYVKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENLKAAQEEYVKR 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 53533000.0 18757000.0 23050000.0 11726000.0 True False 24590608.64304636 19611029.84819627 10512706.003734505 1.0 0.7975007911706083 0.4275089793967848 24.551604107784726 -6.961773781142892 0.4096725273930566 1.0182912841332643 0.19299511353198767 0.9998304258802467 0.0030866045370069022 0.07907352326715003 0.01883447354865624 0.004763895116776621 0.03089481566011558 1.0920090028991895e-07 6.961773781142892 -0.8252961706012767 down ENLK(ub)AAQEEYVKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENLKAAQEEYVKR 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 104347000.0 27246000.0 29375000.0 47726000.0 True False 26381090.643706355 41104590.68860135 35225128.85069021 1.0 1.5581080874837725 1.3352415685321086 24.65300087374948 -10.090182784117927 4.481770516023198 0.9999653172550951 1.4466748279990147 0.8426657389862164 0.0909848754549745 63271775.98038031 1.8813220397534578 24393.427367936845 0.03114654291031925 8.124884873007456e-11 10.090182784117927 0.4467095107439196 ENLK(ub)AAQEEYVKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENLKAAQEEYVKR 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 268382000.0 80958000.0 85494000.0 101930000.0 True False 122819204.82259487 70236927.7323291 81783490.82249402 1.0 0.5718725164666407 0.6658852004507395 26.87196092677771 -10.356716221878427 6.789276477216858 1.0000163542871037 0.6188788584587004 0.9563556987000101 0.03838051751842773 9.501368725217434e-06 9.002470170435328e-07 0.03716336842062577 0.012387258763974382 4.398289160127812e-11 10.356716221878427 -0.3811374958284033 ENLK(ub)AAQEEYVKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENLKAAQEEYVKR 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 55231000.0 18757000.0 21865000.0 14609000.0 True False 25691969.788865548 20898932.002114076 11158655.08179939 1.0 0.8134421834471918 0.434324622576637 24.614814169307618 -6.959731453744605 0.4392015620441325 1.0136690300447788 0.21933609605083443 0.9997601104669335 0.003645241162145576 0.0797971854747484 0.021486773075098376 0.004993527144793835 0.03141705692685314 1.0971564137650663e-07 6.959731453744605 -0.7943329339939444 down ENLK(ub)AAQEEYVKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENLKAAQEEYVKR 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 107282000.0 27246000.0 57604000.0 22432000.0 True False 22656256.202455804 57293675.8185013 27122427.486150682 1.0 2.5288236196892497 1.1971275061415827 24.433406149183757 -6.6128005889186765 2.1440752469514353 2.0194988653170762 1.2020525262572688 0.05905886603360444 0.658660782013529 0.6048529730982442 5.273441663272178 0.2533710619809746 0.7306368118693278 2.4389304230007626e-07 6.6128005889186765 -0.8174463390598075 ENLK(ub)AAQEEYVKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENLKAAQEEYVKR 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 270748000.0 80958000.0 120830000.0 68960000.0 True False 104801726.92076035 114105704.28189373 56409987.58935248 1.0 1.0887769470456155 0.5382543708655065 26.64308724887016 -6.8655824617975965 1.1572737888454165 1.049085441299237 0.5086167741421823 0.9600683226218002 0.048224943432490654 0.1411572771713567 0.35612645468536175 0.0324206857822589 0.07621786512418839 1.3627542282648934e-07 6.8655824617975965 -0.5404686671570547 ENLK(ub)VWIYPEGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENLKVWIYPEGTR 13 1 O15120 O15120 AGPAT2 1-acyl-sn-glycerol-3-phosphate acyltransferase beta 1 53439100.0 3393700.0 23653800.0 26391600.0 True False 5148491.0127033675 19432594.582017083 21175288.692150794 1.0 3.774425270252812 4.1129116550661085 22.295718219582835 -10.009226402513278 0.4948050439180332 1.3270044976881946e-20 4.105683925628446 0.9992080449383518 0.03924421744584238 1.3003216007098672 0.22624774963396807 2.023599685748443 0.0691863909915687 9.789794995264212e-11 10.009226402513278 4.105683925628446 ENLK(ub)VWIYPEGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENLKVWIYPEGTR 13 1 O15120 O15120 AGPAT2 1-acyl-sn-glycerol-3-phosphate acyltransferase beta 1 11357000.0 2283300.0 1354100.0 7719600.0 True False 3127497.713862389 1294271.3845901054 5896389.4701525485 1.0 0.41383607695486035 1.8853377395024986 21.57657739913474 -6.798609771250569 1.4615364269465863 0.6760073077696099 1.9049711152550357 0.8280708957597185 0.25080222615050224 0.22275271275342695 0.9395161637734343 0.1350059874693742 0.31425018677392313 1.589974754754345e-07 6.798609771250569 1.2289638074854259 ENLK(ub)VWIYPEGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENLKVWIYPEGTR 13 1 O15120 O15120 AGPAT2 1-acyl-sn-glycerol-3-phosphate acyltransferase beta 1 33671600.0 3393700.0 10320000.0 19957900.0 True False 4393211.549828103 9745682.927990919 16325766.985347154 1.0 2.2183504749213014 3.7161349505206385 22.066844541675284 -6.96835253948665 0.29489167780672926 0.7239486805047955 5.257130649118121 0.9999665301817697 0.0064263885201563216 0.07684096440878385 0.010933366362840678 0.02550044485284568 0.13507538937654648 1.0755917452282419e-07 6.96835253948665 4.5331819686133255 ENLLDFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENLLDFIK 8 0 P07237;H7BZ94;H0Y3Z3;I3L398;I3L312;I3NI03;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 28792800.0 4444800.0 11847000.0 12501000.0 False True 5827175.843504428 10079473.779244304 11207516.438059427 1.0 1.7297356472398075 1.9233187291837919 22.47436541608699 -10.982123445767364 0.2552382974226991 4.733958739538775e-18 2.012790039121297 0.9992252314442844 0.011066027187593688 2.9250674804051684 0.13476141013337223 1.8103840747358901 0.08609588804489962 1.042021198620901e-11 10.982123445767364 2.012790039121297 ENLLDFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENLLDFIK 8 0 P07237;H7BZ94;H0Y3Z3;I3L398;I3L312;I3NI03;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 32647600.0 14334000.0 7470600.0 10843000.0 False True 13878975.016034901 10453649.538664352 8002893.016972599 1.0 0.7532004003600308 0.5766198878322467 23.72639769078148 -7.4127082715974115 0.11011161545852977 1.4026628791730829 3.178550893237205e-11 0.9999971925755193 0.00029087427596583834 0.12427920824736897 0.008084498404016902 0.03894862278877622 0.060288701184503246 3.866265983270468e-08 7.4127082715974115 -1.4026628791412974 ENLLDFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENLLDFIK 8 0 P07237;H7BZ94;H0Y3Z3;I3L398;I3L312;I3NI03;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 39378800.0 4444800.0 16439000.0 18495000.0 False True 6088162.676203534 15712670.623496616 14126861.916481609 1.0 2.5808559099302433 2.3203818077494045 22.53757547760988 -10.166304337029773 4.51751074308138 0.9997638280335752 2.4506188588693076 0.9763894126971848 0.10633810726039274 6142916.348499398 13824210.791436253 9284.022688021183 0.036402363389576683 6.818607046744254e-11 10.166304337029773 1.4508550308357324 ENLLDFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENLLDFIK 8 0 P07237;H7BZ94;H0Y3Z3;I3L398;I3L312;I3NI03;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 17301200.0 14334000.0 1463000.0 1504200.0 False True 11919356.103868514 1455118.5286172351 1818721.2653650057 1.0 0.12208029661476141 0.15258552974809825 23.506802966215755 -10.152043505834593 4.95746154703138 1.0000535470306968 0.1373329131791954 0.9990630498316114 0.01245370928680402 69708215.54625323 4.19801697918623 42942.799545584196 0.004263235936598787 7.046224792502228e-11 10.152043505834593 -0.8627206338515014 ENLPSSQK(ub)ESEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENLPSSQKESEVK 13 1 O75113;I3L3R7 O75113 N4BP1 NEDD4-binding protein 1 1 10421500.0 4496700.0 3397700.0 2527100.0 True False 5895217.246104738 2890776.404130866 2265619.933654909 1.0 0.49035960566863673 0.38431491819099906 22.491113548619616 -13.999999999999998 0.22065626480572478 4.084267053424709 0.3279468501515553 0.9994985582883562 0.006018123960114395 13.017511663684562 0.1488051624714853 17.50072555521967 0.0584345717343348 1.0000000000000041e-14 13.999999999999998 -3.7563202032731535 ENLPSSQK(ub)ESEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENLPSSQKESEVK 13 1 O75113;I3L3R7 O75113 N4BP1 NEDD4-binding protein 1 1 11921800.0 3757500.0 2374800.0 5789500.0 True False 3638220.2192515098 3323070.0244183964 4273056.268722939 1.0 0.9133779222144093 1.1744908255174378 21.794801440407717 -6.817295972752199 1.3836221196052596 0.9531802564609773 1.1798632778238054 0.8780324614424219 0.037924575807346275 0.1970180558339208 0.7418580213647575 0.021543615551144705 0.04969178878039697 1.5230144619553992e-07 6.817295972752199 0.22668302136282814 ENLPSSQK(ub)ESEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENLPSSQKESEVK 13 1 O75113;I3L3R7 O75113 N4BP1 NEDD4-binding protein 1 1 9598800.0 4496700.0 2123700.0 2978400.0 True False 6159251.508748292 2029867.9118632374 2274963.2620734656 1.0 0.32956405644096765 0.3693570978295369 22.554323610142507 -9.959311340148087 5.949495468359281 1.000000418505485 0.3494605771350877 0.9972015902338103 0.01624544111982631 9.017317095366152e-08 1.5778299767708643e-08 0.015729590922355485 0.005243193575654416 1.098218258568315e-10 9.959311340148087 -0.6505398413703972 ENLPSSQK(ub)ESEVKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENLPSSQKESEVKR 14 2 O75113;I3L3R7 O75113 N4BP1 NEDD4-binding protein 1 1 18726100.0 4494200.0 9533200.0 4698700.0 True False 6818029.970030208 7831925.976768437 3769999.8854866293 1.0 1.1487080595413892 0.5529456312246052 22.70092351047392 -6.840625840861318 1.2795894386272733 1.079102733636404 0.5331200483226163 0.9255021994342848 0.0691038840128364 0.1680755532377522 0.5343212790051054 0.04234329452225651 0.09756197286208138 1.4433583172092062e-07 6.840625840861318 -0.5459826853137878 ENLPSSQK(ub)ESEVKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENLPSSQKESEVKR 14 2 O75113;I3L3R7 O75113 N4BP1 NEDD4-binding protein 1 1 10049810.0 4494200.0 653410.0 4902200.0 True False 5817830.493926245 617047.1591064483 4010049.9008196625 1.0 0.10606138486685701 0.6892689474205399 22.47204983256637 -10.156128746325285 6.856591013135508 1.0000009857299175 0.39766516643903715 0.5871564889746813 0.2380934903981379 3.5877243378054238e-06 4.413898694405228e-07 0.23053340860478183 0.07684434359603193 6.98025444199381e-11 10.156128746325285 -0.6023358192908803 ENLQPQSSGVQGQVPISPEPLQRPEMLK(ub)EETR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENLQPQSSGVQGQVPISPEPLQRPEMLKEETR 32 2 Q9H467 Q9H467 CUEDC2 CUE domain-containing protein 2 1 11008900.0 4859400.0 2919800.0 3229700.0 True False 4040806.4079209347 2904070.457865076 3905015.3375544273 1.0 0.7186858672992629 0.9663950566648467 21.946211804037155 -10.232718249680689 7.211472393209944 1.0000004612515028 0.8425404622523371 0.35012455646916174 0.10112685309068892 7.499429685855444e-07 7.971628848126192e-08 0.09791594189781848 0.03263855148955018 5.851695921909365e-11 10.232718249680689 -0.15745999899916563 ENLSK(ub)VNQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENLSKVNQK 9 1 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 1 3477360.0 930470.0 1660800.0 886090.0 True False 1219855.1806842976 1413015.1137476969 794405.906775464 1.0 1.1583466104189868 0.6512296864041099 20.218278452759854 -6.822808411533694 1.359680011718476 1.085115989624053 0.6394785749577676 0.8907088792103214 0.07003230309742883 0.18986646447224423 0.6889393239388711 0.04046663790580049 0.09320657388203844 1.5038052215705872e-07 6.822808411533694 -0.44563741466628537 ENLSK(ub)VNQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENLSKVNQK 9 1 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 1 3635700.0 1023100.0 1377400.0 1235200.0 True False 990622.2505166272 1927403.0030461103 911664.0647942962 1.0 1.9456488101705116 0.9202943547036694 19.91797550036521 -6.664253700207466 1.9574245609610046 1.6065352668903143 0.924492697546273 0.2540470519004334 0.40222542698784264 0.47440692666296924 3.4984520157327976 0.1657475222937793 0.44623248711327856 2.1664381748918484e-07 6.664253700207466 -0.6820425693440414 ENLSK(ub)VNQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENLSKVNQK 9 1 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 1 2953970.0 930470.0 1001200.0 1022300.0 True False 1274489.9040062777 956963.6734743476 780853.7949293937 1.0 0.7508601444909005 0.6126794668791252 20.281488514282746 -13.999999999999986 0.07020764243456537 2.43950510801318 0.11333097635669248 0.9999237084965459 0.001399877148033172 12.35822448670779 0.0715817471285804 2.9100317828666133 0.45979677916764267 1.0000000000000327e-14 13.999999999999986 -2.326174131656488 ENLSK(ub)VNQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENLSKVNQK 9 1 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 1 2975220.0 1023100.0 1414900.0 537220.0 True False 850752.9810149224 1407277.6528643386 649550.2181753685 1.0 1.6541554179281268 0.7635003728114769 19.698380775799485 -6.709847199643426 1.7955381376644473 1.4022146978717889 0.7655817817196531 0.464488270762195 0.2756631515473722 0.3753747103665699 2.3589233760527386 0.12217413880981783 0.3104618128493613 1.950530745636285e-07 6.709847199643426 -0.6366329161521358 ENLSYDLVPLK(ub)NGGVGIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENLSYDLVPLKNGGVGIK 18 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;R4GN69 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 66844300.0 9884300.0 17813000.0 39147000.0 True False 14995205.739123676 14634130.97639577 31409578.291260354 1.0 0.9759206529733812 2.0946413698953315 23.837997980801465 -6.901984872873763 0.9486677073133275 0.9559867669121244 2.216906394361233 0.987527262014308 0.05827391535867272 0.1099579258742055 0.1693084627453429 0.04589449443378418 0.12063926875902943 1.2531848244826374e-07 6.901984872873763 1.2609196274491086 up ENLSYDLVPLK(ub)NGGVGIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENLSYDLVPLKNGGVGIK 18 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;R4GN69 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 56396300.0 9884300.0 13692000.0 32820000.0 True False 12795421.19868168 12930028.16376468 26847096.76163791 1.0 1.0105199323252343 2.0981799930434475 23.609124302893914 -6.909015142335502 0.9023997622688562 0.9652655419243695 2.235827717018345 0.9905448802296566 0.05009919299855929 0.1050735049295767 0.14232084653294425 0.040818113826081144 0.11192446749341171 1.2330618399090304e-07 6.909015142335502 1.2705621750939757 up ENMYAVQTLK(ub)DFQYVDR ddPTM_RPMI8226_Bortezomib_1h_R1 2 ENMYAVQTLKDFQYVDR 17 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 736087400.0 202098900.0 349275000.0 184713500.0 True False 264953615.0285317 297164531.46328646 165601118.9170061 1.0 1.1215719077140582 0.6250192845988277 27.98116457075324 -6.841971279965364 1.27321769220008 1.0646652768368778 0.6080402488231654 0.9277908118054936 0.0567889147874877 0.1665075126539724 0.5234742530831696 0.03496257316138587 0.08059418740335655 1.4388937296176152e-07 6.841971279965364 -0.4566250280137124 ENMYAVQTLK(ub)DFQYVDR ddPTM_RPMI8226_Bortezomib_2h_R1 2 ENMYAVQTLKDFQYVDR 17 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 1649736400.0 639188000.0 566095400.0 444453000.0 True False 618897326.813822 792140245.3685124 328037425.9958055 1.0 1.2799219047310664 0.5300352930664481 29.205124849664955 -6.8056176389683865 1.4328843049756073 1.1533659626212396 0.5181934505828284 0.8480604450767801 0.12060218511661473 0.21284641032127324 0.8620803413161127 0.06619685287763095 0.15345250974067018 1.564524473235584e-07 6.8056176389683865 -0.6351725120384112 ENMYAVQTLK(ub)DFQYVDR ddPTM_RPMI8226_Bortezomib_8h_R1 2 ENMYAVQTLKDFQYVDR 17 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 2632448500.0 898128500.0 1195593000.0 538727000.0 True False 1362526596.4884233 982230087.9392555 432247372.3175677 1.0 0.7208887448294305 0.3172395852173299 30.343637245525333 -7.004821707030827 0.35006967475079476 1.0400259491106647 1.194905665596721e-10 0.9999285821928156 0.0023685887181736248 0.07372401272581627 0.014034646713765518 0.005537478307807623 0.03307374351872163 9.889590133538734e-08 7.004821707030827 -1.040025948991174 down ENMYAVQTLK(ub)DFQYVDR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ENMYAVQTLKDFQYVDR 17 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 759345800.0 202098900.0 306992600.0 250254300.0 True False 276820324.8474152 293428651.84322935 191149388.48909217 1.0 1.05999677590498 0.6905178967420643 28.04437463227613 -6.865260164689702 1.158803917192949 1.033133505934064 0.6707361802034711 0.9597232696712439 0.03249105120895215 0.14148449524290593 0.35806817058268386 0.021816137841155096 0.051268869394422115 1.3637659260375276e-07 6.865260164689702 -0.3623973257305929 ENMYAVQTLK(ub)DFQYVDR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ENMYAVQTLKDFQYVDR 17 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 1463897100.0 639188000.0 529946800.0 294762300.0 True False 531513142.82960194 527091871.4021967 356395734.1031117 1.0 0.9916817269957469 0.6705304260319462 28.98553012509923 -6.912458916315359 0.8788081425367811 1.0091870112250743 0.6267655814034483 0.9918171902673718 0.013875523851916616 0.10281477715873306 0.1301081835508337 0.011500024771369093 0.03231369588649417 1.2233228383018984e-07 6.912458916315359 -0.38242142982162597 ENMYAVQTLK(ub)DFQYVDR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ENMYAVQTLKDFQYVDR 17 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 2501715900.0 898128500.0 1316307600.0 287279800.0 True False 1162645048.0094864 1243053924.9326265 234997824.1396704 1.0 1.0691602970836238 0.20212344648265596 30.114763567617782 -6.8875987612150835 1.0365125071056904 1.0493041216808514 0.13097432153636673 0.9793152123902235 0.05658510564988691 0.12111180982186974 0.23341646131997482 0.04172248913774092 0.10315227799350304 1.29539208395595e-07 6.8875987612150835 -0.9183298001444846 down ENMYAVQTLK(ub)DFQYVDRDGK ddPTM_RPMI8226_Bortezomib_8h_R1 2 ENMYAVQTLKDFQYVDRDGK 20 2 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 104723100.0 31298000.0 24272300.0 49152800.0 True False 47481354.190290846 19940718.424654502 39437727.5355624 1.0 0.41996945463556407 0.8305939922755355 25.500857746111254 -9.84156302015857 5.743534097011532 1.0000000832113531 0.6252817234544289 0.5261442606321438 0.16763676551808343 1.7866749659648496e-07 3.6215498367231555e-08 0.1623136365438497 0.0541045334213774 1.440247001880089e-10 9.84156302015857 -0.37471835975692425 ENMYAVQTLK(ub)DFQYVDRDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENMYAVQTLKDFQYVDRDGK 20 2 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 81935000.0 21187000.0 47099000.0 13649000.0 True False 27426989.158207305 44477899.24665158 11165022.050566606 1.0 1.6216836266674912 0.4070815788843364 24.709092920924366 -6.767569830865129 1.5836848689668142 1.357691776400013 0.4008581678583829 0.7211868796888372 0.26185181041199984 0.2703862973288154 1.337951571535856 0.13035463177856904 0.31100403821512174 1.7077731025678977e-07 6.767569830865129 -0.95683360854163 ENNAVYAFLGLTAPPGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENNAVYAFLGLTAPPGSK 18 0 O75368 O75368 SH3BGRL SH3 domain-binding glutamic acid-rich-like protein 0 5079200.0 1542700.0 2375200.0 1161300.0 False True 2022494.6395280517 2020829.418457084 1041139.8159761961 1.0 0.9991766499458529 0.5147800125784984 20.947704448228354 -6.9072699215228495 0.9141294016430218 1.0163233343994587 0.455702921992845 0.9898497917638462 0.02302511101892918 0.10625104502218634 0.1487664490840361 0.018600117158126695 0.050423321369139684 1.2380268922658054e-07 6.9072699215228495 -0.5606204124066136 ENNAVYAFLGLTAPPGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENNAVYAFLGLTAPPGSK 18 0 O75368 O75368 SH3BGRL SH3 domain-binding glutamic acid-rich-like protein 0 8884500.0 1542700.0 2080400.0 5261400.0 False True 2113077.8798999265 1988481.0490371864 4018765.6819343725 1.0 0.9410353815881879 1.9018540301622473 21.010914509751245 -6.892297736420726 1.0087152813441311 0.9511816544359314 1.9883040210195702 0.9823278612295854 0.05845163653982874 0.11729772851677284 0.21112784374088725 0.04401475575181622 0.11067462421101888 1.2814517649624843e-07 6.892297736420726 1.0371223665836387 ENNAVYAFLGLTAPPGSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENNAVYAFLGLTAPPGSK 18 0 O75368 O75368 SH3BGRL SH3 domain-binding glutamic acid-rich-like protein 0 8665700.0 4515000.0 1880100.0 2270600.0 False True 3754422.548414004 1869971.528129371 2745371.961931782 1.0 0.49807167520856455 0.7312368084651315 21.840159599406487 -10.370198655039298 5.933195188631691 1.0000706506680863 0.6146542418368485 0.7845650060053463 0.09518926704777364 8.897614391363896e-05 9.44487749269478e-06 0.09218342216921327 0.030722203834476273 4.263844373622266e-11 10.370198655039298 -0.38541640883123784 ENPGFDFSGAEISGNYTK(ub)GGPDFSNLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENPGFDFSGAEISGNYTKGGPDFSNLEK 28 1 E5RFP0;Q8WVJ2 E5RFP0 NUDCD2 NudC domain-containing protein 2 1 8823500.0 2471400.0 4405400.0 1946700.0 True False 2055078.601583696 4381667.23579657 2353745.9694761736 1.0 2.132116617057832 1.1453313599111572 20.97076214374032 -6.61294409584304 2.1429322257329546 1.7548789031688055 1.1489487329392005 0.05957622715430988 0.4877301008497824 0.6045930050875573 5.265478956468869 0.18767467320131068 0.5412032698729486 2.4381246435177824e-07 6.61294409584304 -0.6059301702296049 ENPLQFK(ub)FR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENPLQFKFR 9 1 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 A0A2R8Y5S7;P15311 RDX;EZR Radixin;Ezrin 1 9277000.0 3049600.0 3418200.0 2809200.0 True False 3998055.132368414 2908217.8840392395 2518530.931749188 1.0 0.7274081491508687 0.6299390199397353 21.93086693601554 -13.999999999999998 0.1432051579456236 2.306281555695239 0.5138498031836553 0.9995904695492329 0.0031693713715889786 11.93866233072425 0.11878789449735586 4.350770440825507 0.10402212127901696 1.0000000000000041e-14 13.999999999999998 -1.7924317525115838 ENPLQFK(ub)FR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENPLQFKFR 9 1 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 A0A2R8Y5S7;P15311 RDX;EZR Radixin;Ezrin 1 15512000.0 4318000.0 6810500.0 4383500.0 True False 4180927.453553699 9529968.166288318 3235329.8478188077 1.0 2.279390941880144 0.7738306592880119 21.995391579626496 -6.681610245737933 1.8964294271985058 1.8083416251127196 0.779532981061616 0.3313335324412803 0.5420515523279229 0.4349917982228634 3.026105944845216 0.22924786523262985 0.6033231982683986 2.0815639327410256e-07 6.681610245737933 -1.0288086440511037 ENPLQFK(ub)FR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENPLQFKFR 9 1 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 A0A2R8Y5S7;P15311 RDX;EZR Radixin;Ezrin 1 18096200.0 6172300.0 4113800.0 7810100.0 True False 9363830.355573272 3379660.2487338944 6266430.311711561 1.0 0.360927112132307 0.6692165570878625 23.158667366718337 -10.528058864909811 6.383803743005019 1.0004708665338395 0.5150718346101831 0.7673852685300859 0.12585863887115875 0.0008442338982043027 6.241248827783777e-05 0.12197456208049738 0.04062070102702761 2.9644295591707455e-11 10.528058864909811 -0.4853990319236564 ENPLQFK(ub)FR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENPLQFKFR 9 1 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 A0A2R8Y5S7;P15311 RDX;EZR Radixin;Ezrin 1 11809900.0 3049600.0 4320600.0 4439700.0 True False 4177119.532341235 4129701.6056864434 3391134.298491668 1.0 0.9886481757853326 0.8118355896296245 21.994076997538432 -6.919972607641685 0.8249364004050614 1.003905111951758 0.7833415340616147 0.994173165452772 0.006576195277521383 0.09818787152662203 0.10569995200365363 0.005665238561402706 0.016965473932139725 1.2023402677172278e-07 6.919972607641685 -0.22056357789014325 ENPLQFK(ub)FR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENPLQFKFR 9 1 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 A0A2R8Y5S7;P15311 RDX;EZR Radixin;Ezrin 1 12735600.0 4318000.0 4621200.0 3796400.0 True False 3590608.319834258 4596304.678363623 4590209.687429667 1.0 1.28009080048469 1.2783933190578556 21.775796855060772 -9.959677956453561 4.920731159211238 0.9999978775592958 1.2792420597787724 0.9999722841757575 0.0006929939165327401 1.6136912186990946e-08 3.4096051028952304e-09 0.0006709935622098899 0.00022366282111189635 1.0972915720819729e-10 9.959677956453561 0.27924418221947656 ENPLQFK(ub)FR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENPLQFKFR 9 1 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 A0A2R8Y5S7;P15311 RDX;EZR Radixin;Ezrin 1 15580900.0 6172300.0 5063000.0 4345600.0 True False 7990164.024222535 4781239.599265307 3554745.3896213793 1.0 0.5983906694244033 0.4448901648132644 22.929793688810786 -13.999999999999998 0.13326563236770905 2.9101667188073113 0.238579684741653 0.999631091018254 0.004495325998589461 11.93303702627573 0.11383375888743939 5.954265828949929 0.18373045247354863 1.0000000000000041e-14 13.999999999999998 -2.6715870340656585 ENPPMK(ub)PDFSQLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENPPMKPDFSQLQR 14 1 Q9NVP2 Q9NVP2 ASF1B Histone chaperone ASF1B 1 11024000.0 2910700.0 3289600.0 4823700.0 True False 3815955.8872588957 2798804.5027603675 4324589.79619769 1.0 0.7334478137195722 1.1332913492624674 21.863613063099287 -6.727023893028782 1.7340900324843114 0.8390587617859427 1.1329260609362357 0.5453821872284417 0.11208111535082849 0.3418603634131935 2.0125346627794705 0.051249209821285016 0.12760175547714298 1.8748913567097506e-07 6.727023893028782 0.29386729915029297 ENPPMK(ub)PDFSQLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENPPMKPDFSQLQR 14 1 Q9NVP2 Q9NVP2 ASF1B Histone chaperone ASF1B 1 26404600.0 6041400.0 6072200.0 14291000.0 True False 5849619.06389516 8496861.126104686 10547758.379189815 1.0 1.4525494794265754 1.803153036800698 22.479911246580297 -6.973976393951693 0.1322942972562554 0.47494152899884945 2.7898509576556165 0.9999991589913609 0.0003014437996805726 0.07503222862869278 0.003979361660362155 0.021512828317887932 0.04735387204295419 1.0617532671600546e-07 6.973976393951693 2.314909428656767 ENPPMK(ub)PDFSQLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENPPMKPDFSQLQR 14 1 Q9NVP2 Q9NVP2 ASF1B Histone chaperone ASF1B 1 198530000.0 13019000.0 44741000.0 140770000.0 True False 19750774.81639074 36756618.98697146 112946747.79831709 1.0 1.8610216221222844 5.718598325802643 24.23540591506271 -6.94228002268544 0.637998837038916 0.9578225379807361 6.832569238419501 0.9984475582375968 0.08084142416072032 0.08674168410131322 0.04998711633099963 0.08012574895668584 0.3288234973812847 1.1421416717155197e-07 6.94228002268544 5.874746700438765 ENPPMK(ub)PDFSQLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENPPMKPDFSQLQR 14 1 Q9NVP2 Q9NVP2 ASF1B Histone chaperone ASF1B 1 22093800.0 2910700.0 8029100.0 11154000.0 True False 3986864.4487098693 7674347.813316897 8519654.923840806 1.0 1.9249081357155946 2.136931173217521 21.926823124622178 -10.728263518840158 0.2949318159735077 8.822647313174261e-15 2.2056339219982357 0.9991573871078997 0.01432894404740434 2.4256102276848344 0.14730975786391612 1.8048664204686158 0.07781005256756193 1.8695474023460327e-11 10.728263518840158 2.205633921998227 ENPPMK(ub)PDFSQLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENPPMKPDFSQLQR 14 1 Q9NVP2 Q9NVP2 ASF1B Histone chaperone ASF1B 1 29176500.0 6041400.0 7784100.0 15351000.0 True False 5023691.7793994155 7742165.508277131 18560823.12499549 1.0 1.5411306760548735 3.6946580204437707 22.260316522014573 -6.9449916277121915 0.6113631211015996 0.9762243748212092 4.371976046770734 0.9987473068318705 0.04119390368103959 0.08556138496125781 0.044781355066039696 0.04181879624827811 0.18167845971580593 1.1350326965140172e-07 6.9449916277121915 3.395751671949525 ENPPMK(ub)PDFSQLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENPPMKPDFSQLQR 14 1 Q9NVP2 Q9NVP2 ASF1B Histone chaperone ASF1B 1 282078000.0 13019000.0 26769000.0 242290000.0 True False 16853352.14285652 25279281.618157852 198195706.10533968 1.0 1.4999557004374797 11.760016904966122 24.00653223715516 -6.9170437088460925 0.846367103983203 0.7486126629435222 13.30702239534024 0.9933194709392585 0.4052954394200006 0.09994248778705261 0.11485971219677676 0.34384357976956453 1.0025772762227128 1.2104763010449355e-07 6.9170437088460925 12.558409732396719 up ENPVVVGEKIQK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENPVVVGEKIQK 12 1 Q6FIF0-2;Q6FIF0 Q6FIF0-2 ZFAND6 AN1-type zinc finger protein 6 1 2465200.0 1214200.0 1251000.0 0.0 True False 1175655.8856194778 1750530.8238788156 0.0 1.0 1.488982316416869 0.0 20.165034414567383 -6.83967773812252 1.430084793890427 1.2625024280686816 6.582646024036814e-23 0.8795299722003697 0.21508787403234017 0.18468406346958222 0.7583278018157326 0.12061360530183966 0.2581374597860049 1.4465127362573058e-07 6.83967773812252 -1.2625024280686816 down ENPYANAGK(ub)NPDEVSYAGDNFVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENPYANAGKNPDEVSYAGDNFVR 23 1 O95391 O95391 SLU7 Pre-mRNA-splicing factor SLU7 1 42441600.0 6816600.0 12151000.0 23474000.0 True False 10341280.560212685 9982559.113803683 18834353.610980295 1.0 0.9653116996178253 1.821278660927553 23.301911509775252 -6.897455546458338 0.9772270782378364 0.9618849198880761 1.9066208463128638 0.9852568656231072 0.04803234476063593 0.11330217272129442 0.18817704003965838 0.037033721339015106 0.0951809838279648 1.2663228792336713e-07 6.897455546458338 0.9447359264247877 ENPYANAGK(ub)NPDEVSYAGDNFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENPYANAGKNPDEVSYAGDNFVR 23 1 O95391 O95391 SLU7 Pre-mRNA-splicing factor SLU7 1 54994700.0 6816600.0 8103100.0 40075000.0 True False 8824223.07527426 7652155.361802633 32781761.20422423 1.0 0.8671761011169588 3.714974216379424 23.0730378318677 -6.8959614329895595 0.9864541021161081 0.8681257149250039 3.9905396762154792 0.9844474657000017 0.1636540294023971 0.11443910751134356 0.1946618257838198 0.12531185451510665 0.3199085062944375 1.270686942056995e-07 6.8959614329895595 3.1224139612904755 up ENQK(ub)HIYYITGETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENQKHIYYITGETK 14 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 11497600.0 2723600.0 3451100.0 5322900.0 True False 2637140.8088232665 4829142.227248753 3928672.8064228888 1.0 1.83120378369314 1.489747075043719 21.33054317456819 -10.323770719568094 5.653560351351059 0.9999007447202858 1.6604754293684352 0.8330167318709422 0.13939911757356319 0.00017442232566225745 2.0862910652969304e-05 0.1349926692536973 0.04499087173653213 4.7449242158695166e-11 10.323770719568094 0.6605746846481494 ENSEGAGAK(ub)ASSAGVLVS ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENSEGAGAKASSAGVLVS 18 1 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 1 5953900.0 2482500.0 1634800.0 1836600.0 True False 2403694.396351796 2287584.1653693747 1355539.3631810246 1.0 0.9516950943686321 0.5639399772443587 21.196822054019727 -6.930033102254258 0.7465252722065248 1.005889504699356 0.48427005681168267 0.9965446220620243 0.011472802366157728 0.09262088801355785 0.07759748638301675 0.010454282365727343 0.03507884945999349 1.174808006771018e-07 6.930033102254258 -0.5216194478876732 ENSEGAGAK(ub)ASSAGVLVS ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENSEGAGAKASSAGVLVS 18 1 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 1 4278400.0 1767800.0 1392400.0 1118200.0 True False 2421403.432998696 1330879.1639489434 854104.1900518917 1.0 0.5496313195115802 0.35273105605295957 21.20741203787929 -13.999999999999995 0.11248115772486113 3.1643910363110974 0.004092645122459688 0.9997304834808645 0.004447611025445306 11.998631781377817 0.10216895680872282 5.871671327799898 0.3095011510406657 1.0000000000000123e-14 13.999999999999995 -3.1602983911886375 ENSETVVTGSLDDLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENSETVVTGSLDDLVK 16 0 H0YN81;Q9GZS3;H0YMF9;H0YM76 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 0 8531600.0 1508400.0 3906200.0 3117000.0 False True 1977527.0073663797 3323410.1862483425 2794482.74037527 1.0 1.6805890255194926 1.413119886588498 20.91526596724726 -10.064586997464462 4.730562957375368 0.9999805709265271 1.546854455858319 0.8478760833379619 0.10919381876055041 75741830.95022509 2.1967737718575937 16955.28482848751 0.0373799485410006 8.6181292385437e-11 10.064586997464462 0.5468738849317919 ENSETVVTGSLDDLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENSETVVTGSLDDLVK 16 0 H0YN81;Q9GZS3;H0YMF9;H0YM76 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 0 12039500.0 3504100.0 0.0 8535400.0 False True 3392864.263547363 0.0 6299722.683488695 1.0 0.0 1.8567564730403052 21.69407228342134 -6.760415210609145 1.610763094488997 0.41943740496400905 1.8637095541832438 0.6926858908507065 0.42063067600441745 0.28223629940019396 1.4433199966834507 0.20602320491938395 0.49493191716444546 1.7361401847456143e-07 6.760415210609145 1.4442721492192347 ENSETVVTGSLDDLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENSETVVTGSLDDLVK 16 0 H0YN81;Q9GZS3;H0YMF9;H0YM76 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 0 8485200.0 1508400.0 2707600.0 4269200.0 False True 2066096.2429772802 2587969.279164146 3260902.8869339437 1.0 1.2525889284977538 1.5782918622585203 20.978476028770153 -6.967648585169371 0.3092395742611335 0.9493700419388966 1.8918524937014995 0.9999577961006506 0.0015377956592900381 0.0770733171439643 0.011747394935614278 0.00517107861481802 0.02893758885006763 1.0773366014672379e-07 6.967648585169371 0.9424824517626029 ENSPEK(ub)FALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENSPEKFALK 10 1 G5E975;Q12824-2;Q12824;A0A0G2JRV3 G5E975 SMARCB1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 1 5586500.0 2267300.0 1450300.0 1868900.0 True False 2972452.2565644323 1233920.8932251208 1675524.1557546828 1.0 0.4151188267196223 0.5636841271560936 21.503222206958387 -10.334988738971148 8.718224127278525 1.0000008135089415 0.4894014769381144 0.9402962469047769 0.060651529925439616 9.590353427289152e-07 7.312239609467018e-08 0.05872568451110106 0.019575197110269033 4.623930108528359e-11 10.334988738971148 -0.5105993365708271 ENSPEK(ub)FALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENSPEKFALK 10 1 G5E975;Q12824-2;Q12824;A0A0G2JRV3 G5E975 SMARCB1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 1 5864500.0 1612200.0 1639100.0 2613200.0 True False 1561021.593473665 2293601.1777935824 1928724.5256804156 1.0 1.4692949715639385 1.2355527519568255 20.574059063450953 -10.125110353591381 4.5123490209739945 0.9999602573938776 1.3524238617712787 0.7519265007423113 0.09542486160088368 66589091.871615715 2.727475341612026 27496.637244450492 0.03266646827298638 7.497036865196636e-11 10.125110353591381 0.3524636043774011 ENSPEK(ub)FALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENSPEKFALK 10 1 G5E975;Q12824-2;Q12824;A0A0G2JRV3 G5E975 SMARCB1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 1 5154600.0 2267300.0 1604100.0 1283200.0 True False 3105582.0814786423 1533225.5579506597 980134.5883335596 1.0 0.49369989835227734 0.3156041484715464 21.56643226848128 -13.999999999999998 0.14561920460071906 3.4331736934812485 0.1094395108566957 0.9995815125848897 0.00593077507141888 11.943952404400148 0.11993752604383284 8.235649903677693 0.18509216094809394 1.0000000000000041e-14 13.999999999999998 -3.323734182624553 ENVK(ub)DYYQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ENVKDYYQK 9 1 P09234;A0A0A0MRR7 P09234 SNRPC U1 small nuclear ribonucleoprotein C 1 2563530.0 1137200.0 892610.0 533720.0 True False 1490880.2126604638 759436.0673665282 478495.77420375065 1.0 0.5093877166773316 0.3209485042060346 20.507732915783123 -13.999999999999451 0.1325276706264228 3.3328696536134177 0.06533209559108055 0.999634327106396 0.005473348435628954 11.933665234966227 0.11345138445614558 7.236242736224809 0.22756341109883207 1.0000000000012639e-14 13.999999999999451 -3.267537558022337 ENVK(ub)DYYQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENVKDYYQK 9 1 P09234;A0A0A0MRR7 P09234 SNRPC U1 small nuclear ribonucleoprotein C 1 4354500.0 1177800.0 1508200.0 1668500.0 True False 1140411.3836951253 2110432.125159098 1231469.7960729282 1.0 1.850588441445526 1.079846986517057 20.121122914903957 -10.220438690731438 4.59539182399825 0.9998783067503144 1.4652177139847726 0.32694988451612617 0.3146538813760605 0.0003924065818944138 6.656829620623055e-05 0.30474148663940165 0.10155410353074175 6.019512342418134e-11 10.220438690731438 0.4653394072344582 ENVK(ub)DYYQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ENVKDYYQK 9 1 P09234;A0A0A0MRR7 P09234 SNRPC U1 small nuclear ribonucleoprotein C 1 6684600.0 1778200.0 2523900.0 2382500.0 True False 2697659.4038333218 2073490.325679295 1911597.8307131545 1.0 0.7686256918619546 0.7086134847107871 21.363276779945803 -13.999999999999998 0.1894616323377596 2.2380073605334085 0.6653261507111754 0.9994897107455596 0.0028378791196137674 12.341974326279848 0.13803260362394637 5.639741994847278 0.04144844289818878 1.0000000000000041e-14 13.999999999999998 -1.5726812098222331 ENVK(ub)DYYQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ENVKDYYQK 9 1 P09234;A0A0A0MRR7 P09234 SNRPC U1 small nuclear ribonucleoprotein C 1 2687570.0 1137200.0 881970.0 668400.0 True False 1557653.5716744629 843001.6491152318 510537.6861301048 1.0 0.5411997021963061 0.3277607392388807 20.570942977306014 -11.581552557356448 0.13377426275173726 2.195491619877889 3.4335241937312764e-17 0.999711515111227 0.004763697510492807 4.459890501686886 0.08713375239366092 1.7884133612877864 0.23965941993659942 2.6208818461256313e-12 11.581552557356448 -2.195491619877889 ENVK(ub)DYYQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ENVKDYYQK 9 1 P09234;A0A0A0MRR7 P09234 SNRPC U1 small nuclear ribonucleoprotein C 1 4002720.0 1177800.0 2166600.0 658320.0 True False 979392.8853869367 2154928.0957635725 795971.6682722324 1.0 2.200269297353745 0.8127194715711676 19.901528190338233 -6.6778987923265545 1.9091995143066376 1.7608510819492493 0.818068330957357 0.31456867152629286 0.5089381278722253 0.4432280308468778 3.121681243672257 0.21403562704183984 0.5660605305917332 2.0994290760614416e-07 6.6778987923265545 -0.9427827509918923 ENVK(ub)DYYQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ENVKDYYQK 9 1 P09234;A0A0A0MRR7 P09234 SNRPC U1 small nuclear ribonucleoprotein C 1 6669600.0 1778200.0 2193500.0 2697900.0 True False 2301914.953562291 2071429.7967585332 2206909.8827916775 1.0 0.8998724273253127 0.9587278102418207 21.134403102038252 -10.205457360020276 4.3778813858133745 1.0000224745630688 0.9293001187835941 0.6580020272180869 0.024027609473887705 33799853.515279084 0.1546495664523275 8005.611755797407 0.00822528981775484 6.23078319614782e-11 10.205457360020276 -0.07072235577947472 ENYIHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ENYIHR 6 0 P60842;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 7838900.0 2589300.0 1393200.0 3856400.0 False True 2507104.088811163 1949512.0254420207 2846293.150479856 1.0 0.7775951681234163 1.1352911764543179 21.25759046389823 -6.738504193822082 1.6918353167721842 0.8674484893894954 1.1354490821388143 0.5984255492492282 0.0934485957120131 0.320492717851832 1.800574620768128 0.04370400681207637 0.10743628927059508 1.8259791161810856e-07 6.738504193822082 0.268000592749319 EPFAVVK(ub)TASEMER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EPFAVVKTASEMER 14 1 A0A075B6T1;Q9C0C7-4;Q9C0C7-2;Q9C0C7-3;Q9C0C7;Q9C0C7-5;Q9C0C7-6 A0A075B6T1 AMBRA1 Activating molecule in BECN1-regulated autophagy protein 1 1 16626000.0 2968600.0 7297600.0 6359800.0 True False 4503583.233730514 5995286.263590954 5102782.742400632 1.0 1.3312258156323222 1.133049502489993 22.1026418944221 -10.236588596214991 4.196344513215131 0.9998604842710612 1.232137659012019 0.6465775271359324 0.08090514115820281 57078579.44276644 20.499780355580675 80123.1235603249 0.027695981752414285 5.7997784478545466e-11 10.236588596214991 0.23227717474095777 EPFAVVK(ub)TASEMER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EPFAVVKTASEMER 14 1 A0A075B6T1;Q9C0C7-4;Q9C0C7-2;Q9C0C7-3;Q9C0C7;Q9C0C7-5;Q9C0C7-6 A0A075B6T1 AMBRA1 Activating molecule in BECN1-regulated autophagy protein 1 1 14771000.0 2968600.0 5830000.0 5972400.0 True False 3842911.2198543563 5505555.375018129 4885484.481998969 1.0 1.4326522420225951 1.2712977746553629 21.87376821651455 -10.091064044379896 5.026088786146743 0.9999904913469491 1.3519750083402589 0.8638445047954089 0.06587268546582174 45812513.53330686 0.260847233266256 5041.340358408909 0.022549972344996103 8.108414761624476e-11 10.091064044379896 0.3519845169933098 EPFHSILSVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EPFHSILSVLK 11 0 Q8NCW5-2;Q8NCW5;Q5T3I4 Q8NCW5-2 APOA1BP NAD(P)H-hydrate epimerase 0 7576200.0 1185200.0 3459100.0 2931900.0 False True 1553808.677493125 2943015.7634661947 2628535.112770694 1.0 1.8940657277151913 1.6916723087243308 20.567377443066878 -10.058254907096064 4.340270252246669 0.9999405022554193 1.7928690182422389 0.9534060988399033 0.08262676773886643 5689613.316536261 3771878.9868401573 3156.0180254032243 0.028285339811270918 8.744703583194864e-11 10.058254907096064 0.7929285159868196 EPFHSILSVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EPFHSILSVLK 11 0 Q8NCW5-2;Q8NCW5;Q5T3I4 Q8NCW5-2 APOA1BP NAD(P)H-hydrate epimerase 0 8226600.0 1185200.0 2412500.0 4628900.0 False True 1623400.4688256888 2305907.772929347 3535649.155187976 1.0 1.4204183238885968 2.177927888455977 20.63058750458977 -6.962033305380141 0.4057618407223973 0.9609149142408415 2.6653501912900697 0.9998383352010056 0.006197248592246034 0.07898262360340874 0.01850525715289504 0.00974640147498354 0.06333593298990785 1.0913566387666272e-07 6.962033305380141 1.7044352770492281 up EPFPTIYVDSQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EPFPTIYVDSQK 12 0 O43776;K7EIU7;K7EQ35;O43776-2;K7EPK2;K7EJ19 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 17756600.0 3079700.0 7163600.0 7513300.0 False True 4037516.5238572205 6094818.803494095 6735895.7886626655 1.0 1.5095464668641012 1.6683264944826932 21.94503673348692 -11.526793391410715 0.20714653495190144 1.5687762911982148e-10 1.7791570685679383 0.9993680031610608 0.00716714011841983 4.118703706583722 0.12230154529844968 1.9386163874014974 0.09499067473165289 2.973080090214393e-12 11.526793391410715 1.7791570684110607 EPFPTIYVDSQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EPFPTIYVDSQK 12 0 O43776;K7EIU7;K7EQ35;O43776-2;K7EPK2;K7EJ19 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 13042200.0 3079700.0 4675400.0 5287100.0 False True 4218348.315763141 4468825.368519737 4038395.8712424873 1.0 1.0593779920497823 0.9573405439640423 22.00824679500981 -6.748924855981417 1.6536023122226817 1.0349589481548758 0.9571513384883457 0.6444511746003969 0.024949859554390625 0.30190968891468495 1.6238824665792544 0.011920224486526593 0.028974338661507625 1.7826871911020082e-07 6.748924855981417 -0.07780760966653011 EPIPVLPTVHYNMGGIPTNYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EPIPVLPTVHYNMGGIPTNYK 21 0 P31040-2;P31040;D6RFM5;A0A087X1I3;P31040-3 P31040-2 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0 8196300.0 1591800.0 3011400.0 3593100.0 False True 2180331.476777533 2878346.3906318895 2744483.7822173573 1.0 1.3201416487762687 1.2587461179405735 21.05611605457834 -10.05220420825661 4.430108096580897 0.9999824513990927 1.2894438833142858 0.9673567987103641 0.02506462060539041 17364577.689390354 0.3212792878145237 3243.5276376713346 0.008580286298218557 8.867389632280769e-11 10.05220420825661 0.28946143191519313 EPK(ub)PGPSHNQAANDIVNPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EPKPGPSHNQAANDIVNPR 19 1 Q9NWF9;Q9NWF9-1;F8W6D1 Q9NWF9 RNF216 E3 ubiquitin-protein ligase RNF216 1 15094300.0 2549600.0 4009500.0 8535200.0 True False 3300507.460129577 3786367.8003662378 6981881.17854759 1.0 1.1472077691403206 2.1153962725094044 21.654256428318824 -6.9339244359917105 0.7138464745288003 0.9872024562480952 2.3355991922766632 0.997254874911914 0.025922901316216877 0.09065062433860423 0.06806929052390392 0.024194798101320723 0.0857925676253733 1.1643285962994649e-07 6.9339244359917105 1.348396736028568 up EPLPPIQQHIWNMLNPPAEVTTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EPLPPIQQHIWNMLNPPAEVTTK 23 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 5750100.0 1831900.0 1145000.0 2773200.0 False True 1773747.3372313618 1602204.4710961182 2046815.7257833076 1.0 0.9032878795448936 1.1539499920987493 20.758369087822267 -6.80214612265925 1.4475626509945676 0.9467839085151691 1.1575790152366372 0.8382385014974747 0.041513791883281116 0.217716740028982 0.9005046315427839 0.022560907967409234 0.052391172026643895 1.5770805561241545e-07 6.80214612265925 0.21079510672146806 EPLYEK(ub)DSSVAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EPLYEKDSSVAAR 13 1 O43809 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 1 13644700.0 3361900.0 5736400.0 4546400.0 True False 2795568.807422602 5705496.874613751 5497031.219821474 1.0 2.0409073314399944 1.9663372996672928 21.41471042382657 -10.557247455473432 6.6196155448667415 0.9988231588642669 2.003622315553613 0.995876605880955 0.030443087991041406 0.0005291887931651093 3.539469455956357e-05 0.02950142424923354 0.00982546439970254 2.771740352225069e-11 10.557247455473432 1.0047991566893462 EPPLSLTIHLTSPVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EPPLSLTIHLTSPVVR 16 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7EQR9;K7EKY0;K7EPG3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 25376600.0 9758400.0 8377500.0 7240700.0 False True 12793356.900480025 7127609.6552392375 6491501.82169882 1.0 0.5571336523076128 0.5074119226248781 23.608891532671485 -13.999999999999998 0.3087175987546364 5.248932482607921 0.4962486555437642 0.9996691734451567 0.004027344726076029 17.17912621644958 0.17674365214176596 46.8550280354679 0.01732159283738933 1.0000000000000041e-14 13.999999999999998 -4.752683827064157 EPPLSLTIHLTSPVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EPPLSLTIHLTSPVVR 16 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7EQR9;K7EKY0;K7EPG3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 188923000.0 124440000.0 33954000.0 30529000.0 False True 120489720.31501226 47512009.26777085 22532539.04963169 1.0 0.3943241725813115 0.18700797869496155 26.844334826025737 -12.420788041468242 0.17359103855395802 2.763778136777895 2.652890005648664e-21 0.9994879633573466 0.007805111620305607 6.471946017674295 0.1186999712659655 4.160743483361231 0.16069798197706897 3.79500155804333e-13 12.420788041468242 -2.763778136777895 EPPLSLTIHLTSPVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EPPLSLTIHLTSPVVR 16 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7EQR9;K7EKY0;K7EPG3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 819110000.0 228480000.0 302210000.0 288420000.0 False True 346620864.1254286 248278264.32249296 231413660.5810234 1.0 0.7162819380447067 0.6676276142952658 28.368783256252346 -13.999999999999998 0.24806294028410766 2.95402673218414 0.6477008210569932 0.9995390850000565 0.003146612115069533 13.921910059561371 0.1576053968062009 13.539900991255477 0.02269790841765147 1.0000000000000041e-14 13.999999999999998 -2.3063259111271464 EPPLSLTIHLTSPVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EPPLSLTIHLTSPVVR 16 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7EQR9;K7EKY0;K7EPG3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 53408200.0 9758400.0 8659800.0 34990000.0 False True 13366344.190844258 8277181.401870907 26726082.641670264 1.0 0.61925544364933 1.999505793063239 23.672101594194377 -6.833137550147945 1.3137769953044265 0.7969554161622281 2.0391008865963554 0.9120189023181448 0.1726462218961165 0.17696740833966979 0.5962486217602784 0.10314316270871918 0.23737256980630794 1.4684611116293028e-07 6.833137550147945 1.2421454704341273 EPPLSLTIHLTSPVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EPPLSLTIHLTSPVVR 16 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7EQR9;K7EKY0;K7EPG3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 195154000.0 124440000.0 23980000.0 46734000.0 False True 103477373.6267197 23850814.98034266 56505863.32639832 1.0 0.23049304543021332 0.5460697478681223 26.624740101460013 -10.515522752735706 6.2519361443451045 1.0005723093945893 0.38828139665663747 0.833608898372556 0.1288336492804996 0.001028615440699054 7.970954718690389e-05 0.12485083018689311 0.041580881507875186 3.051246169830896e-11 10.515522752735706 -0.6122909127379519 EPPLSLTIHLTSPVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EPPLSLTIHLTSPVVR 16 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7EQR9;K7EKY0;K7EPG3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 623330000.0 228480000.0 214730000.0 180120000.0 False True 295771864.0141222 202780086.7371599 147340008.18727058 1.0 0.6855962699936793 0.49815424018910587 28.139909578344795 -9.819656570871095 0.10434697098114842 1.7527492277070524 2.2506130768304143e-11 0.9999275629359349 0.0017622062487036875 1.3541927120148785 0.046020292665575266 0.5283187551035149 0.25355122407390035 1.5147586078771427e-10 9.819656570871095 -1.7527492276845462 EPSCHLQDLELVK(ub)CHLTAACCESLSCVISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EPSCHLQDLELVKCHLTAACCESLSCVISR 30 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 105212100.0 8548700.0 30101400.0 66562000.0 True False 12969002.893684575 24729569.986688323 53405991.524839 1.0 1.9068212251483658 4.11797205711518 23.628564228177822 -6.955995018743217 0.48862550017566353 0.9510023745546375 5.167334309196432 0.9995915921212245 0.026463949680486928 0.08116415434921535 0.026663699824537958 0.03174217170509949 0.18236955489275306 1.1066364767680942e-07 6.955995018743217 4.2163319346417945 EPSCHLQDLELVK(ub)CHLTAACCESLSCVISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EPSCHLQDLELVKCHLTAACCESLSCVISR 30 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 37829700.0 8548700.0 10484000.0 18797000.0 True False 11066460.670069706 9900556.183823323 15376138.873507256 1.0 0.8946452238880962 1.3894360023429608 23.39969055027027 -6.8510327440437635 1.2300161672534378 0.943722361885948 1.4096218216135081 0.9418016708996583 0.05133804631037199 0.15632841869174224 0.45460344749378573 0.03264974399262769 0.07560869572354152 1.4091825477637297e-07 6.8510327440437635 0.4658994597275601 EPTSSEQGGLEGSGSAAGEGK(ub)PALSEEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EPTSSEQGGLEGSGSAAGEGKPALSEEER 29 1 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 1073210000.0 441840700.0 395786300.0 235583000.0 True False 579257436.4914259 336736526.8029136 211207131.03170612 1.0 0.5813244778393069 0.3646170385157108 29.109629419588106 -10.49157779414154 0.13445924079744562 1.8537826789562826 2.05093307352025e-12 0.9997760094831043 0.003947002160923897 2.3188260413945656 0.07075021441210766 0.876272391626131 0.22705699161543366 3.224201723970786e-11 10.49157779414154 -1.8537826789542315 EPTSSEQGGLEGSGSAAGEGK(ub)PALSEEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EPTSSEQGGLEGSGSAAGEGKPALSEEER 29 1 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 1271925830.0 517188200.0 377577230.0 377160400.0 True False 500770343.6855078 528345786.9782429 278370776.670533 1.0 1.0550660470222513 0.5558851081751649 28.89957388549739 -6.879535681680914 1.082349470347403 1.0339265809382452 0.520816870096084 0.973310539275214 0.03650818626312013 0.12804385488369627 0.27475821338755735 0.025993467891981776 0.06278727456353346 1.3196668832811694e-07 6.879535681680914 -0.5131097108421612 EPTSSEQGGLEGSGSAAGEGK(ub)PALSEEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EPTSSEQGGLEGSGSAAGEGKPALSEEER 29 1 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 1808965100.0 770508700.0 767115100.0 271341300.0 True False 1168918029.6313055 630217416.9073666 217710573.12188345 1.0 0.5391459460216785 0.1862496493364489 30.122526618423198 -8.021602491297966 0.3222606321611777 1.1084223449089678 2.747377834198925e-18 0.9988943391743657 0.01107890174991224 0.09688499429024931 0.06493974780737874 0.0573169330426026 0.08850372945271893 9.514752782689998e-09 8.021602491297966 -1.1084223449089678 down EPTSSEQGGLEGSGSAAGEGK(ub)PALSEEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EPTSSEQGGLEGSGSAAGEGKPALSEEER 29 1 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 1004415600.0 441840700.0 299849500.0 262725400.0 True False 605201147.0859534 286601157.620302 200675071.5194591 1.0 0.47356347389671694 0.33158408982816806 29.172839481110998 -13.999999999999998 0.18391541265603856 3.765253323126834 0.22324692406135124 0.9994939353363457 0.006468289746849349 12.257903057190632 0.13597816492769402 12.124658336350038 0.10258202959812965 1.0000000000000041e-14 13.999999999999998 -3.542006399065483 EPTSSEQGGLEGSGSAAGEGK(ub)PALSEEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EPTSSEQGGLEGSGSAAGEGKPALSEEER 29 1 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 1329524500.0 517188200.0 623276300.0 189060000.0 True False 430064903.6220717 619918586.8612411 228591571.88532677 1.0 1.4414535611722625 0.5315280785762659 28.679979160931666 -6.774781583247435 1.5560436543382323 1.2516625708044138 0.5254491703005872 0.7485095910547497 0.18631796149552549 0.25878886849390004 1.2371889809336705 0.09434245851187564 0.22361377934986018 1.6796485398888604e-07 6.774781583247435 -0.7262134005038265 EPTSSEQGGLEGSGSAAGEGK(ub)PALSEEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EPTSSEQGGLEGSGSAAGEGKPALSEEER 29 1 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 1752383900.0 770508700.0 820905200.0 160970000.0 True False 997438701.147138 775221103.9863346 131675111.69167763 1.0 0.7772117756156498 0.13201323704428175 29.893652940515647 -7.1497397563646725 0.6277102150024616 1.0010591375829516 4.4012453472948354e-23 0.9980775984885889 0.01613834666534479 0.08177818261465582 0.0538747510216226 0.015717967761029066 0.050896063787759765 7.083701360720376e-08 7.1497397563646725 -1.0010591375829516 down EPTSSEQGGLEGSGSAAGEGK(ub)PALSEEERQEQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTK 34 2 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 10352400.0 4352000.0 2627000.0 3373400.0 True False 4213848.142164364 3675974.7996240235 2489805.3401692663 1.0 0.8723557839784724 0.590862616821883 22.006706892854332 -6.95808965926584 0.4615688519036007 1.0080777314829572 0.4437632246325388 0.9996926545182949 0.002996450936882455 0.08039071429900616 0.023707075955510724 0.003833292419899768 0.02325028861986475 1.1013119223286671e-07 6.95808965926584 -0.5643145068504184 EPTSSEQGGLEGSGSAAGEGK(ub)PALSEEERQEQTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTK 34 2 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 117694000.0 42335000.0 50574000.0 24785000.0 True False 64225290.10307259 41548674.563534446 19886233.88634859 1.0 0.6469207767976547 0.3096324493736653 25.936638165948278 -7.432759663843208 0.2772276852515639 1.1020176104679777 2.387556496593062e-13 0.999834537149852 0.0036257037072882246 0.12015502694715223 0.02484202581673563 0.020690747845709522 0.05964977020024196 3.6918184523536135e-08 7.432759663843208 -1.102017610467739 down EPTSSEQGGLEGSGSAAGEGK(ub)PALSEEERQEQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTK 34 2 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 13817000.0 3986600.0 5810900.0 4019500.0 True False 5460553.753814116 5554155.223923373 3070176.884201015 1.0 1.0171413879121467 0.5622464355481422 22.38061583134331 -6.89814396983043 0.9729408566956086 1.0198880405368254 0.5162595034490179 0.9856196495491203 0.025244632031372987 0.11278392262293438 0.18523118230311236 0.01952638147222249 0.05034660317037487 1.2643171533350318e-07 6.89814396983043 -0.5036285370878074 EPTSSEQGGLEGSGSAAGEGK(ub)PALSEEERQEQTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTK 34 2 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 145731000.0 42335000.0 77504000.0 25892000.0 True False 54803492.04760971 73190834.26850852 21179921.674354922 1.0 1.335514061858049 0.3864702938264442 25.707764488040727 -6.81116223146981 1.4097111167854621 1.182604553814024 0.36943506363378464 0.862811849509024 0.1455436529689265 0.20522886293366677 0.8036225925655459 0.08117670420982338 0.18767539608658965 1.5446773148163872e-07 6.81116223146981 -0.8131694901802393 down EPTSSEQGGLEGSGSAAGEGK(ub)PALSEEERQEQTKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKR 35 3 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 95993800.0 28600000.0 36400800.0 30993000.0 True False 43388290.94007023 29904792.839251492 24867219.96528552 1.0 0.6892364781216499 0.5731320461465789 25.370802423888996 -13.999999999999998 0.13668133138974758 2.4806968386503248 0.4235353224356975 0.9996164896023664 0.0035290612347889873 11.932066685064054 0.1155774778990931 4.721792446543229 0.13346156525203406 1.0000000000000041e-14 13.999999999999998 -2.0571615162146273 EPTSSEQGGLEGSGSAAGEGK(ub)PALSEEERQEQTKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EPTSSEQGGLEGSGSAAGEGKPALSEEERQEQTKR 35 3 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 148884600.0 28600000.0 73629300.0 46655300.0 True False 37023263.7902831 69531764.72964361 38164514.12380392 1.0 1.8780560547958092 1.0308252222166416 25.141928745981446 -10.26447264945286 4.871234568492311 0.9998812726142222 1.4544406385067263 0.2772528145844936 0.34588053903044924 0.0004460977186333275 6.735916319472324e-05 0.3349842843931555 0.11163246395326823 5.439103844655132e-11 10.26447264945286 0.4545593658925041 EPVSTK(ub)CDHIFCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EPVSTKCDHIFCK 13 1 P38398-7;P38398;P38398-4;Q5YLB2;A0A0U1RRA9;E7EWN5;E9PH68;Q3B891;E7EQW4;E7EUM2;E9PC22;E7ENB7;A0A2R8Y6Y9;P38398-2;P38398-6;P38398-5;P38398-3 P38398-7 BRCA1 Breast cancer type 1 susceptibility protein 1 5048400.0 2046300.0 1002200.0 1999900.0 True False 2648975.6886033705 946426.6889953976 1635938.720706875 1.0 0.35728024725450985 0.6175740788204052 21.337003172528764 -10.342886271783772 5.8204011892125935 1.0000767520638676 0.48742716303751565 0.837935331621377 0.10626451175507029 0.00010585164746850431 1.1950505135965746e-05 0.1029054674854862 0.034296723693353424 4.540605054058577e-11 10.342886271783772 -0.5126495890263519 EPVVTLEGHTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EPVVTLEGHTK 11 0 H3BNA2;H3BU76;H3BSL1;P31146;H3BRY3;H3BTU6;H3BRJ0 H3BNA2;P31146 CORO1A Coronin;Coronin-1A 0 22618600.0 6095400.0 8367400.0 8155800.0 False True 7991128.427937561 7119016.5358697465 7311916.0519578485 1.0 0.8908649886017539 0.9150041972038471 22.92996780995436 -10.280814490397384 5.534890959134864 1.0000101496509108 0.902934592902798 0.9556710994548815 0.009854790644964542 1.234401786609923e-06 1.603831233375894e-07 0.009542857660404877 0.003180620004024327 5.238241411483541e-11 10.280814490397384 -0.09707555674811286 EPVVTLEGHTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EPVVTLEGHTK 11 0 H3BNA2;H3BU76;H3BSL1;P31146;H3BRY3;H3BTU6;H3BRJ0 H3BNA2;P31146 CORO1A Coronin;Coronin-1A 0 11537500.0 2833700.0 1238500.0 7465300.0 False True 2743745.7445889586 1733039.5086921765 5509913.975800553 1.0 0.6316326912251135 2.008172217366298 21.38771536642678 -6.835492794906981 1.3031537744146673 0.8037858896186882 2.049556587191405 0.9164248135248667 0.168209794590375 0.17412963582556568 0.5763505362750886 0.10128354394314987 0.23313198902432172 1.4605189797467667e-07 6.835492794906981 1.245770697572717 up EPVVTLEGHTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EPVVTLEGHTK 11 0 H3BNA2;H3BU76;H3BSL1;P31146;H3BRY3;H3BTU6;H3BRJ0 H3BNA2;P31146 CORO1A Coronin;Coronin-1A 0 18481200.0 6095400.0 6155400.0 6230400.0 False True 8349034.101991315 5883434.074814213 4758907.839115814 1.0 0.7046843985714425 0.5699950175051716 22.99317787147725 -13.999999999989479 0.10563951304434156 2.4373513076877056 0.30664607158829266 0.999765228311038 0.002751641603972317 12.040052649618653 0.09788673013458996 3.723389131276316 0.23423498645523472 1.0000000000242264e-14 13.999999999989479 -2.1307052360994128 EPVVTLEGHTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EPVVTLEGHTK 11 0 H3BNA2;H3BU76;H3BSL1;P31146;H3BRY3;H3BTU6;H3BRJ0 H3BNA2;P31146 CORO1A Coronin;Coronin-1A 0 7336700.0 2833700.0 3230200.0 1272800.0 False True 2356347.104195077 3212798.2714555003 1538936.5952377222 1.0 1.3634656225883093 0.6531026742613201 21.168120641861055 -6.767640538932066 1.5836197800162117 1.2091070803045803 0.6494730469488095 0.7213767074607148 0.1530920920358454 0.27027750868451794 1.3373483119980882 0.07621780771455625 0.1818156592207096 1.707495080372339e-07 6.767640538932066 -0.5596340333557708 EPVVTLEGHTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 EPVVTLEGHTKR 12 1 H3BNA2;H3BU76;H3BSL1;P31146;H3BRY3;H3BTU6;H3BRJ0 H3BNA2;P31146 CORO1A Coronin;Coronin-1A 1 9567200.0 2927500.0 2099800.0 4539900.0 True False 2834568.114932486 2938261.0903123394 3350763.9959193827 1.0 1.0365815782776924 1.1821074181521976 21.43469750699257 -6.94500080430178 0.6112726084574073 0.9983931568789055 1.2278909240888425 0.9987482342412324 0.0027828219756119536 0.08555749198291801 0.044764541581395624 0.002825277556526172 0.012276625291536999 1.1350087136645479e-07 6.94500080430178 0.22949776720993698 EPVVTLEGHTK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EPVVTLEGHTKR 12 1 H3BNA2;H3BU76;H3BSL1;P31146;H3BRY3;H3BTU6;H3BRJ0 H3BNA2;P31146 CORO1A Coronin;Coronin-1A 1 9967400.0 2927500.0 3996100.0 3043800.0 True False 2434345.9602396498 3974572.2161362506 3680244.5070589106 1.0 1.632706394675707 1.511800116815199 21.215102782426847 -10.127529864524835 4.425088385935265 0.9999243792624205 1.5722532557717253 0.9676048159697294 0.04935978136818076 34724680.51640161 20071309.22700296 30097.777931047716 0.018063829825071858 7.455386028484482e-11 10.127529864524835 0.5723288765093048 EPYNYFLLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EPYNYFLLLR 10 0 H0Y4W2;F2Z2U4;Q9Y4A5-2;Q9Y4A5 H0Y4W2 TRRAP Transformation/transcription domain-associated protein 0 1985720.0 591550.0 686450.0 707720.0 False True 775527.7785783489 584034.3357611429 634491.9233296078 1.0 0.7530798404562112 0.8181420973633213 19.5648189324222 -10.775450896154402 5.405117322143871 1.0131065475319019 0.7856109689101968 0.9353889714923711 0.02656155515604845 0.004336854692963999 0.00018016926683046356 0.026586756692700424 0.00857270506406211 1.677061943350894e-11 10.775450896154402 -0.2274955786217051 EPYNYFLLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EPYNYFLLLR 10 0 H0Y4W2;F2Z2U4;Q9Y4A5-2;Q9Y4A5 H0Y4W2 TRRAP Transformation/transcription domain-associated protein 0 2296610.0 591550.0 520260.0 1184800.0 False True 810262.0210376623 497273.19293024746 904974.6417219451 1.0 0.6137189946203012 1.116891349002128 19.62802899394509 -6.701592787608086 1.825013298314731 0.7605136994884942 1.1154491619803562 0.4252251411966165 0.16300656592374094 0.39221634617753964 2.5407723436311755 0.07122361431586895 0.18282102877431036 1.9879580350772873e-07 6.701592787608086 0.3549354624918619 EQADFALEALAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQADFALEALAK 12 0 Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4;M0QY43 Q7Z406 MYH14 Myosin-14 0 11907300.0 2256500.0 4610100.0 5040700.0 False True 2958293.351977084 3922291.050029054 4519136.717808672 1.0 1.3258627807846413 1.5276161557096584 21.496333690205446 -9.799737332373422 0.08362823312735235 2.066282092971002e-14 2.26054683870129 0.9999669492362558 0.0012496751207637037 1.3566136047931874 0.03720248035154326 0.6497927102054674 0.36258454054497263 1.585852048878065e-10 9.799737332373422 2.260546838701269 EQADFALEALAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQADFALEALAK 12 0 Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4;M0QY43 Q7Z406 MYH14 Myosin-14 0 13584700.0 4447700.0 1433900.0 7703100.0 False True 4306510.198047897 2006463.747689718 5685427.021953478 1.0 0.4659140824975244 1.3201935582390196 22.038087816973963 -6.737687310796682 1.695320326218998 0.6813655714707011 1.3204290871257949 0.5944199694683466 0.22441580680639447 0.3220308194105066 1.8164431152206368 0.10476287941548057 0.25771865435377134 1.829416910361365e-07 6.737687310796682 0.6390635156550938 EQADFALEALAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQADFALEALAK 12 0 Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4;M0QY43 Q7Z406 MYH14 Myosin-14 0 13413900.0 2256500.0 5433600.0 5723800.0 False True 3090789.029619617 5193525.585487624 4371956.325361306 1.0 1.680323547067459 1.414511402578442 21.559543751728338 -10.096641182316763 4.642290255277612 0.999971409115859 1.547417474739924 0.8497352171812078 0.10851735367751456 3.936600843894277e-05 7.660292132047083e-06 0.10507818718497411 0.035023825281812984 8.004953577326239e-11 10.096641182316763 0.5474460656240651 EQADFALEALAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQADFALEALAK 12 0 Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4;M0QY43 Q7Z406 MYH14 Myosin-14 0 7887900.0 4447700.0 1138300.0 2301900.0 False True 3698459.6165184937 1132167.7519651412 2783216.6472169324 1.0 0.3061187276206886 0.7525340103177561 21.81849309240824 -9.882972680375024 6.428629176389384 1.0000000310288344 0.5293263689699685 0.5971280071310855 0.1822482759981708 8.114868513517688e-08 1.3906882544928063e-08 0.17646114760125664 0.05882037815130517 1.3092642806752013e-10 9.882972680375024 -0.47067366205886585 EQAEAEVASLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQAEAEVASLNR 12 0 P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;A0A494C0G0 P06753-2 TPM3 Tropomyosin alpha-3 chain 0 52013000.0 7609000.0 24237000.0 20167000.0 False True 9975472.685660822 20620934.075086024 18080312.295523915 1.0 2.067163604660805 1.8124767482460598 23.249953774077873 -10.706838820536532 7.657762565407496 0.9946532970222465 1.9398201764534322 0.947796467975009 0.10397547373493503 0.009460992474261005 0.00036219361097047215 0.10035348290018019 0.033557939849119166 1.9640890728466917e-11 10.706838820536532 0.9451668794311857 EQATGAK(ub)DTK(ub)PMGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 EQATGAKDTKPMGR 14 2 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 2 25158800.0 4671500.0 9093100.0 11394200.0 True False 6124381.738870356 7736444.924626196 10215237.484884143 1.0 1.2632205591503813 1.667962240180075 22.546132779596714 -6.964842118194036 0.36075502086771394 0.9654228449615093 1.9796461892996877 0.9999098493918153 0.0026084628169510426 0.07801461125049566 0.015049335920378777 0.005421984292421185 0.03455447603429312 1.0843210324270982e-07 6.964842118194036 1.0142233443381783 EQATGAK(ub)DTK(ub)PMGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQATGAKDTKPMGR 14 2 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 2 22909100.0 3938900.0 4567200.0 14403000.0 True False 3813861.7755448516 6390906.7776333615 10630422.219261859 1.0 1.6757048770390612 2.787311875701942 21.86282112683179 -6.963677735118505 0.3800702835756496 0.923703613573035 3.578626315205343 0.9998832294251634 0.007962593666839775 0.07841266476650814 0.016460513331265185 0.01446542786747653 0.09392652475794193 1.0872320965802921e-07 6.963677735118505 2.654922701632308 EQATGAK(ub)DTK(ub)PMGR ddPTM_RPMI8226_Bortezomib_8h_R1 2 EQATGAKDTKPMGR 14 2 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 2 26428100.0 5239700.0 9062400.0 12126000.0 True False 7949007.973380646 7445143.91514563 9729290.784985395 1.0 0.9366129635393073 1.2239628916672995 22.922343394351863 -6.8488645543706586 1.240568768121012 0.9662046559652413 1.235200167667863 0.938635856948193 0.030534823523500062 0.15871004091801427 0.47060579389569035 0.019265722542091166 0.04455061863918983 1.416235399626933e-07 6.8488645543706586 0.2689955117026217 EQATGAK(ub)DTK(ub)PMGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EQATGAKDTKPMGR 14 2 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 2 28608800.0 4671500.0 6579700.0 17357600.0 True False 6398679.792540684 6288987.097841752 13258092.370993286 1.0 0.9828569801497478 2.0720043510301953 22.609342841119606 -6.90332716839701 0.9400158169593872 0.9587576535786148 2.1943691659724904 0.9881495536782576 0.055457123874849225 0.10899684208786929 0.1639385087844809 0.043955847312451904 0.11639514059975507 1.2493175234180042e-07 6.90332716839701 1.2356115123938758 up EQATGAK(ub)DTK(ub)PMGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQATGAKDTKPMGR 14 2 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 2 20373100.0 3938900.0 7022000.0 9412200.0 True False 3275369.872856684 6984171.092242138 11380247.502904207 1.0 2.1323305041426495 3.474492330534469 21.643226402266066 -6.968874540503637 0.28378204582560035 0.7174609859749878 4.930473220319275 0.9999722249841495 0.005330368625696713 0.07666960381814247 0.010331181627878655 0.024263553056051008 0.12261640760513384 1.074299712472835e-07 6.968874540503637 4.213012234344287 EQATGAK(ub)DTK(ub)PMGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQATGAKDTKPMGR 14 2 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 2 7834100.0 2351400.0 3033900.0 2448800.0 True False 3043933.6530234884 2865060.797987561 2003143.5268098405 1.0 0.9412362832355903 0.658077262893083 21.537505482864336 -6.940633234261477 0.6536489849323373 1.0031469985398003 0.5802753256930286 0.9982456264284331 0.0062523566859777405 0.08747902906814735 0.05330364779328838 0.0061157871918426825 0.024303753294188855 1.1464807464058591e-07 6.940633234261477 -0.42287167284677163 EQATGAK(ub)DTKPMGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQATGAKDTKPMGR 14 2 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 14180100.0 3331100.0 4557300.0 6291700.0 True False 4367104.358418284 3877368.604216267 5640695.23824803 1.0 0.8878580143710159 1.2916328018071512 22.058245576186245 -6.832624262469012 1.316295393739718 0.9401811219387084 1.30308025747058 0.9109939176631386 0.05077213704510976 0.17759637802801806 0.600889466442819 0.030277855694636868 0.06967209900334691 1.4701976950367828e-07 6.832624262469012 0.3628991355318716 EQATGAK(ub)DTKPMGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 EQATGAKDTKPMGR 14 2 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 23673800.0 5652000.0 7705600.0 10316200.0 True False 5472580.353748379 10782486.264173139 7614077.740633829 1.0 1.9702746359471546 1.3913140143147749 22.38378980193793 -10.719419072964657 6.68600158872845 0.9909416019062008 1.6807943251309647 0.6483361642461445 0.23635968402731444 0.03172182765885982 0.0013312186611079922 0.2274699943743462 0.076284759996053 1.9080112323220928e-11 10.719419072964657 0.6898527232247639 EQATGAK(ub)DTKPMGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQATGAKDTKPMGR 14 2 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 15659500.0 3545000.0 6156300.0 5958200.0 True False 5378024.1742150085 5057660.16560856 4780559.158428168 1.0 0.9404309095257628 0.8889062234693194 22.358644809462763 -6.972820049898803 0.1784049874369302 1.0406832733374904 0.7872627533279003 0.9999968293832058 8.062216192504001e-05 0.07539786877430814 0.005616251592932284 0.0020124363578038966 0.00581052341689547 1.0645840376933801e-07 6.972820049898803 -0.25342052000959014 EQATGAK(ub)DTKPMGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EQATGAKDTKPMGR 14 2 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 18400840.0 4233640.0 5614000.0 8553200.0 True False 5798931.117819106 5365954.9169846065 6533110.318683457 1.0 0.9253351709069213 1.126605953053718 22.4673555707483 -6.806292617544664 1.4303538866195684 0.9591264701552976 1.1298264752065967 0.8498419263587241 0.03219194701635053 0.21190715079949776 0.855186084781895 0.01770146508894467 0.041014657355579756 1.5620947847655972e-07 6.806292617544664 0.17070000505129912 EQATGAK(ub)DTKPMGR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 EQATGAKDTKPMGR 14 2 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 18637300.0 5652000.0 8222000.0 4763300.0 True False 4699888.426054475 8177706.454060784 5759284.006989191 1.0 1.7399788490140635 1.2254086660997763 22.164195077372206 -10.486234366712877 5.821291787442248 0.999506948812477 1.4826937575569197 0.5398609749312278 0.2100723974984357 0.0013455705348080626 0.00011875465649604009 0.20360054056440136 0.0678005747507754 3.2641163682364754e-11 10.486234366712877 0.48318680874444264 EQATGAK(ub)DTKPMGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQATGAKDTKPMGR 14 2 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 15451600.0 3545000.0 5902600.0 6004000.0 True False 4589072.382396988 5574115.121197587 4911333.606242349 1.0 1.2146496408683984 1.0702236088237589 22.129771131555213 -10.091359489301043 4.595624336735296 0.9999909867231093 1.1424366247592739 0.5646218896761153 0.0589616806956192 41007313.55537517 2.4970186178749594 4123.533995673138 0.02018415158864153 8.102900587717218e-11 10.091359489301043 0.1424456380361646 EQCCYNCGK(ub)PGHLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQCCYNCGKPGHLAR 15 1 P62633-2;P62633;P62633-7;P62633-3;P62633-8;P62633-5;P62633-4;P62633-6 P62633-2 CNBP Cellular nucleic acid-binding protein 1 5275600.0 2359800.0 1800300.0 1115500.0 True False 3093720.6523357057 1531702.2575144372 1000078.7606315735 1.0 0.49510037577504884 0.3232608477034057 21.560911503769663 -13.999999999999998 0.1504581918893381 3.4431381757486084 0.13519557974451946 0.9995647174912209 0.005992270651343227 11.959489598839806 0.12218480746391185 8.54116310989193 0.16958703969892341 1.0000000000000041e-14 13.999999999999998 -3.307942596004089 EQCCYNCGK(ub)PGHLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQCCYNCGKPGHLAR 15 1 P62633-2;P62633;P62633-7;P62633-3;P62633-8;P62633-5;P62633-4;P62633-6 P62633-2 CNBP Cellular nucleic acid-binding protein 1 4929900.0 2359800.0 1479700.0 1090400.0 True False 3232281.8311971505 1414321.9612864463 832869.9774929195 1.0 0.43756146126732376 0.25767244967758485 21.624121565292555 -13.999999999999998 0.15949194923527119 3.7669772079875665 0.07983761953683309 0.9995377131266777 0.006798211310434594 12.006345711308965 0.12618783071163203 10.277424449806707 0.1619778805335271 1.0000000000000041e-14 13.999999999999998 -3.6871395884507336 EQCCYNCGKPGHLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQCCYNCGKPGHLAR 15 1 P62633-2;P62633;P62633-7;P62633-3;P62633-8;P62633-5;P62633-4;P62633-6 P62633-2 CNBP Cellular nucleic acid-binding protein 0 15474490.0 522390.0 9514600.0 5437500.0 False True 684858.3488319567 8095058.767620318 4874879.660183035 1.0 11.820048308422676 7.118084591503141 19.38544609671387 -10.006617605329293 12.013383308361217 0.9999991364006631 9.469066443874908 0.8122294558292207 1.919568649255576 0.0 1.0489930247825625e-17 1.8586143526171488 0.6195381175390494 9.848779054187627e-11 10.006617605329293 8.469067307474244 EQCCYNCGKPGHLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQCCYNCGKPGHLAR 15 1 P62633-2;P62633;P62633-7;P62633-3;P62633-8;P62633-5;P62633-4;P62633-6 P62633-2 CNBP Cellular nucleic acid-binding protein 0 11601090.0 522390.0 6006700.0 5072000.0 False True 715531.700058938 5741304.132499358 3874098.0611189282 1.0 8.02382917769604 5.414292701217599 19.448656158236762 -9.14828459612025 9.246244596990927 0.9999999339920638 6.719060939472232 0.8649405930150443 1.0653388054817714 0.0 0.0 1.0315098628994939 0.34383662096649786 7.107476032867356e-10 9.14828459612025 5.719061005480168 EQCEQLEK(ub)CVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQCEQLEKCVK 11 1 P07919;A0A096LP55 P07919 UQCRH;UQCRHL Cytochrome b-c1 complex subunit 6, mitochondrial;Cytochrome b-c1 complex subunit 6 1 2788620.0 1194700.0 762050.0 831870.0 True False 1566263.2694912574 648355.1104476346 745796.0722604987 1.0 0.41395027456541755 0.4761626520825856 20.578895301535724 -10.103467182713313 5.147643405634297 1.0000134653470922 0.44505646332686455 0.9906622359427664 0.02539809677044366 3.9250121388074955e-06 6.835316429101238e-07 0.02459219756777649 0.00819720048429046 7.88011975007449e-11 10.103467182713313 -0.5549570020202277 EQCEQLEK(ub)CVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQCEQLEKCVK 11 1 P07919;A0A096LP55 P07919 UQCRH;UQCRHL Cytochrome b-c1 complex subunit 6, mitochondrial;Cytochrome b-c1 complex subunit 6 1 5648300.0 1321000.0 2505100.0 1822200.0 True False 2004053.578036114 2058045.3325643663 1462041.3713013679 1.0 1.0269412729879017 0.7295420578196843 20.934489648582712 -6.884771277459383 1.05277950093088 1.0180392804337832 0.7064335403985236 0.9773366727994719 0.020217435966220648 0.12348985194280679 0.24743120402920193 0.014723212145507385 0.03607943184912238 1.303853276049401e-07 6.884771277459383 -0.31160574003525965 EQDGQGMK(ub)QRPPR ddPTM_RPMI8226_Bortezomib_1h_R1 2 EQDGQGMKQRPPR 13 2 Q9H1C4;E9PNE5 Q9H1C4 UNC93B1 Protein unc-93 homolog B1 1 111849700.0 18240900.0 21247800.0 72361000.0 True False 23913996.545126885 18077711.063275695 64873777.85572504 1.0 0.7559468794420108 2.7127953177255435 24.511351919899468 -6.875651757130669 1.103829019012288 0.8559369701064977 2.8403776549833277 0.970002466489502 0.15079704470089972 0.13154822474467712 0.29619319875232136 0.10561975312152384 0.25280840284845163 1.331521682454458e-07 6.875651757130669 1.9844406848768301 up EQDGQGMK(ub)QRPPR ddPTM_RPMI8226_Bortezomib_2h_R1 2 EQDGQGMKQRPPR 13 2 Q9H1C4;E9PNE5 Q9H1C4 UNC93B1 Protein unc-93 homolog B1 1 108938100.0 9782500.0 22821500.0 76334100.0 True False 9471959.89216977 31934243.962550305 56339909.23608659 1.0 3.371450505079687 5.948073036358755 23.175231541392147 -6.970063524806454 0.2566641129137846 0.24650310261118452 9.149134288581623 0.9999828741251083 0.00836201940927145 0.07628209993134162 0.008956352425989642 0.05496901228473107 0.24434515897346304 1.0713625842076253e-07 6.970063524806454 8.902631185970439 EQDGQGMK(ub)QRPPR ddPTM_RPMI8226_Bortezomib_8h_R1 2 EQDGQGMKQRPPR 13 2 Q9H1C4;E9PNE5 Q9H1C4 UNC93B1 Protein unc-93 homolog B1 1 141065200.0 14204800.0 57974000.0 68886400.0 True False 21549720.10998289 47628086.74707051 55270972.846018285 1.0 2.2101487399368516 2.5648116339299487 24.361165795773616 -10.190281761462538 0.2836711767965101 6.135946889252655e-11 2.704942268869454 0.9989996365122564 0.02118791315543248 1.6624315661884295 0.13188485953938317 1.4135549603945405 0.1358037814737765 6.45235477503048e-11 10.190281761462538 2.704942268808095 EQDGQGMK(ub)QRPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EQDGQGMKQRPPR 13 2 Q9H1C4;E9PNE5 Q9H1C4 UNC93B1 Protein unc-93 homolog B1 1 124801330.0 18240900.0 17691330.0 88869100.0 True False 24985053.671787504 16909668.543195084 67880048.8965664 1.0 0.6767913635618504 2.7168262189172263 24.57456198142236 -6.866358673592231 1.1530900088459688 0.8206483700264421 2.8283622214297295 0.9609170162298526 0.1769911652790209 0.14039924121473646 0.35117180457742236 0.11936110495457618 0.2809576751634814 1.3603207615157728e-07 6.866358673592231 2.0077138514032873 up EQDGQGMK(ub)QRPPR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 EQDGQGMKQRPPR 13 2 Q9H1C4;E9PNE5 Q9H1C4 UNC93B1 Protein unc-93 homolog B1 1 81818630.0 9782500.0 21634800.0 50401330.0 True False 8134582.188230345 21518249.03822842 60940015.07358015 1.0 2.6452801803837516 7.4914745051998155 22.955636816826424 -6.951862015466287 0.5380137423378174 0.927704395617245 9.432087442954304 0.9993394218183884 0.07081940072481753 0.08274655830407669 0.03293385027034048 0.0781075218408816 0.4012087960199836 1.1172181552119477e-07 6.951862015466287 8.504383047337058 EQDGQGMK(ub)QRPPR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 EQDGQGMKQRPPR 13 2 Q9H1C4;E9PNE5 Q9H1C4 UNC93B1 Protein unc-93 homolog B1 1 253662600.0 14204800.0 35587800.0 203870000.0 True False 18388393.618469033 33607307.64580959 166767751.88284963 1.0 1.8276369509544816 9.06918545159652 24.132292117866065 -6.928468892764905 0.7592569428430154 0.8833960362838567 10.499476862614994 0.9962286528274448 0.22258877772772462 0.09344062592261973 0.08163292562030146 0.200972230262741 0.6608375551197725 1.1790469718826074e-07 6.928468892764905 9.616080826331137 up EQDSESQTLDK(ub)VYQMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQDSESQTLDKVYQMK 16 1 Q14790;Q14790-9;Q14790-7;Q14790-2;Q14790-4;A0A0A0MS31;Q14790-8;C9JB29 Q14790;Q14790-2 CASP8 Caspase-8;Caspase-8 subunit p18;Caspase-8 subunit p10 1 3897300.0 1408800.0 1361200.0 1127300.0 True False 1929671.4313884834 1301057.6831135447 861054.9574722728 1.0 0.6742379360290247 0.44621843048829607 20.879923787459695 -7.959214482827988 0.15297823419741977 1.3423755206417445 4.045500555611442e-12 0.9999498988339399 0.0016085228892792596 0.11132546766862578 0.024814511421545716 0.08650254082154903 0.10883213414762158 1.0984632129580529e-08 7.959214482827988 -1.342375520637699 down EQEIEDQK(ub)NPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQEIEDQKNPR 11 1 O15269 O15269 SPTLC1 Serine palmitoyltransferase 1 1 1659380.0 358740.0 674360.0 626280.0 True False 470311.6140431019 573748.1166346923 561478.5533019648 1.0 1.219931848381084 1.1938436911543244 18.843257433499605 -10.104615605734459 4.5749476203819315 0.9999838062841236 1.2068877697714446 0.9882149887877918 0.010650445611296012 1.8004744075883014e-06 3.523636084755914e-07 0.010313075301264888 0.003437416537048358 7.859309547360377e-11 10.104615605734459 0.20690396348732099 EQEIEDQK(ub)NPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQEIEDQKNPR 11 1 O15269 O15269 SPTLC1 Serine palmitoyltransferase 1 1 6626100.0 434530.0 995120.0 5196450.0 True False 659213.7783982083 817533.0610919519 4169369.3798150504 1.0 1.240163794935288 6.3247606716382645 19.33038687141642 -6.916752157885238 0.8484588126839661 0.8741501904351587 7.086443809426708 0.9932302892837148 0.20203156282192408 0.10012080497604438 0.11579269057263998 0.17114082147984797 0.4977629099529692 1.2112891919050986e-07 6.916752157885238 6.212293618991549 up EQEIEDQK(ub)NPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQEIEDQKNPR 11 1 O15269 O15269 SPTLC1 Serine palmitoyltransferase 1 1 1393100.0 358740.0 450740.0 583620.0 True False 491375.872583976 430824.8164021444 445780.97603119677 1.0 0.8767724270558614 0.9072097367886391 18.906467495022497 -10.608614326076056 6.458871403768123 1.0003202947931416 0.8919910819222503 0.9437879918662722 0.012425979664725592 5.7479803910895464e-05 3.4830797208379107e-06 0.012066812538180247 0.004010467691816189 2.4625534967304023e-11 10.608614326076056 -0.10832921287089126 EQEIEDQK(ub)NPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQEIEDQKNPR 11 1 O15269 O15269 SPTLC1 Serine palmitoyltransferase 1 1 2047000.0 443490.0 1033700.0 569810.0 True False 368781.58493823407 1028131.2529266158 688954.6364962334 1.0 2.7879137541502077 1.8681915383915495 18.492407091208417 -10.118532609680555 5.334589950972679 0.9999736405516786 2.3280526462716504 0.7354547394801421 0.37547502228781643 0.00011771684342637904 1.9451918268150924e-05 0.36355930396178193 0.12118404235273994 7.611449850981095e-11 10.118532609680555 1.3280790057199718 EQEIEDQK(ub)NPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQEIEDQKNPR 11 1 O15269 O15269 SPTLC1 Serine palmitoyltransferase 1 1 5005270.0 434530.0 634000.0 3936740.0 True False 562507.6508668445 598717.3426692085 3220293.7143635103 1.0 1.0643719098692501 5.724888736003718 19.10151319350887 -6.909907683543614 0.896344172185474 0.8552783324892117 6.32603305816764 0.9908870962121825 0.21119120441489905 0.10447968832204524 0.13909156762255342 0.17282599097599094 0.4767849922891051 1.230530312531034e-07 6.909907683543614 5.470754725678429 up EQEQK(ub)VYVQHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQEQKVYVQHR 11 1 Q9UHB4-3;Q9UHB4;Q9UHB4-4 Q9UHB4-3 NDOR1 NADPH-dependent diflavin oxidoreductase 1 1 5800600.0 1104700.0 1831900.0 2864000.0 True False 918606.9965078518 1822031.1910963187 3462849.158360179 1.0 1.9834719287169558 3.7696742693278416 19.80908824622639 -6.961885640619081 0.40799631282327986 0.9100642557324795 4.909153174657324 0.9998338537306785 0.014777294545107966 0.0790343703922764 0.018692751505449273 0.022989756094123813 0.14923256740083093 1.091727774768378e-07 6.961885640619081 3.9990889189248446 EQFLDGDGWTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQFLDGDGWTSR 12 0 P27797;K7EJB9 P27797 CALR Calreticulin 0 73089600.0 4214600.0 37673000.0 31202000.0 False True 5525381.414244458 32052335.248203803 27973516.350718345 1.0 5.800927184062396 5.062730380676073 22.39764262576423 -10.45224288849499 5.104324077261632 0.9929098990853331 5.431828782369306 0.9796157197164878 0.30136758300890604 0.024184891207759657 0.0025953349067512166 0.29022621506307317 0.09726596917327707 3.529856997611246e-11 10.45224288849499 4.438918883283972 EQFLDGDGWTSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQFLDGDGWTSR 12 0 P27797;K7EJB9 P27797 CALR Calreticulin 0 68510900.0 21570000.0 7779900.0 39161000.0 False True 20885272.156821065 10886454.641642533 28903559.29518244 1.0 0.521250312655708 1.3839206440861547 24.315982607651808 -6.756067841935354 1.6271632569566712 0.7205557035411503 1.3864837869782154 0.6747175026586165 0.20126694818179253 0.28959291826740785 1.5102029052039827 0.09763554159827732 0.23556375724064205 1.7536065463587755e-07 6.756067841935354 0.6659280834370651 EQFLDGDGWTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQFLDGDGWTSR 12 0 P27797;K7EJB9 P27797 CALR Calreticulin 0 75412600.0 4214600.0 35578000.0 35620000.0 False True 5772851.5152824465 34006046.3192872 27207289.61692749 1.0 5.890684392152324 4.71297235775106 22.460852687287122 -9.900611132471143 6.047315390763891 0.9999990350832008 5.301828374953273 0.9467791258210205 0.48079892470867075 6.266703975275621e-06 1.1379375921312036e-06 0.46553164022170596 0.15517718568843344 1.257155117303125e-10 9.900611132471143 4.301829339870072 EQFYHSCK(ub)QYGITGENVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQFYHSCKQYGITGENVR 18 1 Q96JB5;Q96JB5-4;Q96JB5-2;J3QQY1;J3QL86 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 1189543000.0 497400000.0 515320000.0 176823000.0 True False 652096216.8284521 438436264.7016271 158527052.1659852 1.0 0.6723490389716018 0.2431037752940823 29.28050960898459 -7.2899197908178985 0.3805622854834333 1.037667660098733 4.674604436690298e-22 0.9996069700597662 0.006144315449183564 0.10109278197597146 0.029162851492499118 0.011524717353088389 0.050630497351146414 5.129561123215179e-08 7.2899197908178985 -1.037667660098733 down EQFYHSCK(ub)QYGITGENVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQFYHSCKQYGITGENVR 18 1 Q96JB5;Q96JB5-4;Q96JB5-2;J3QQY1;J3QL86 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 675043960.0 449180000.0 172323960.0 53540000.0 True False 434921026.7687017 241133815.88557997 39516267.8344289 1.0 0.5544312669293384 0.09085849016778928 28.696178218375987 -7.786244752567591 0.47559677297385966 1.026451036892692 1.820464072854552e-18 0.9959518728736041 0.023616269981738887 0.11257619010488178 0.09388991559250978 0.032564869012744434 0.07733771107779647 1.6358943310750514e-08 7.786244752567591 -1.026451036892692 down EQFYHSCK(ub)QYGITGENVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQFYHSCKQYGITGENVR 18 1 Q96JB5;Q96JB5-4;Q96JB5-2;J3QQY1;J3QL86 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 3252855800.0 1804705800.0 1004850000.0 443300000.0 True False 2737870640.266862 825526666.5711164 355681560.6947077 1.0 0.3015214285254368 0.12991174800721747 31.350407137304384 -13.999999999999975 0.19714522496985432 4.841349001041423 0.015272466779165291 0.9994870378925309 0.008522559458498846 12.475886662529343 0.14079825340073263 18.458189659660647 0.11164451959428279 1.0000000000000573e-14 13.999999999999975 -4.826076534262258 EQFYHSCK(ub)QYGITGENVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQFYHSCKQYGITGENVR 18 1 Q96JB5;Q96JB5-4;Q96JB5-2;J3QQY1;J3QL86 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 1053684380.0 497400000.0 434343380.0 121941000.0 True False 681302221.7295804 415152653.29011667 93141047.25372706 1.0 0.6093516798406938 0.1367103236758506 29.343719670507483 -7.585555788728857 0.45527883286064963 1.025061759413575 1.135959703518257e-28 0.9976257617662785 0.017198675651826933 0.11883561036421864 0.06781996423901873 0.023453644422542837 0.07157632759431626 2.5968341350887313e-08 7.585555788728857 -1.025061759413575 down EQFYHSCK(ub)QYGITGENVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQFYHSCKQYGITGENVR 18 1 Q96JB5;Q96JB5-4;Q96JB5-2;J3QQY1;J3QL86 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 792716000.0 449180000.0 198817000.0 144719000.0 True False 373513072.0479747 197745933.35891536 174979073.79494658 1.0 0.5294217208374343 0.468468406836567 28.476583493810264 -13.999999999999998 0.28812812220584977 5.01250123397286 0.4515429221655098 0.9996232745703405 0.00460986347904397 15.855425594516772 0.17018295804081682 37.668731591111644 0.0232168611587859 1.0000000000000041e-14 13.999999999999998 -4.56095831180735 EQFYHSCK(ub)QYGITGENVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQFYHSCKQYGITGENVR 18 1 Q96JB5;Q96JB5-4;Q96JB5-2;J3QQY1;J3QL86 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 3237835800.0 1804705800.0 1149930000.0 283200000.0 True False 2336227234.1697183 1085935384.6302886 231660505.87738743 1.0 0.46482438383876806 0.09916009131693829 31.121533459396833 -8.245296569716679 0.38947730631535016 1.082901052243965 9.181702653498105e-18 0.997301647387065 0.019216276466481916 0.10817238365619049 0.10124039508506032 0.06903826851399647 0.0833830369810233 5.684646068599109e-09 8.245296569716679 -1.082901052243965 EQFYK(ub)IAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQFYKIAK 8 1 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 1 25810400.0 10142000.0 11676000.0 3992400.0 True False 13296260.215267709 9933986.312691523 3579304.745805018 1.0 0.7471263461950463 0.26919635204604425 23.664517186059594 -7.006490481668577 0.430509934006739 1.0193191714216152 1.2040577337317923e-10 0.9998036207819843 0.0042464963620805 0.07434015473353842 0.02011946801008746 0.006157867940971113 0.03717121705445382 9.851662342272672e-08 7.006490481668577 -1.0193191713012095 down EQFYK(ub)IAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQFYKIAK 8 1 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 1 43167000.0 14765000.0 16928000.0 11474000.0 True False 14296293.156952385 23687438.678353813 8468615.187378345 1.0 1.6568937428954758 0.5923644048429435 23.769137787625308 -6.739787514988743 1.6877244449144722 1.3909447295516515 0.5917977155523175 0.6039188846571757 0.27599846186054616 0.3181818886517423 1.7795186933635818 0.12938235721046507 0.31753606009774293 1.8205913920575212e-07 6.739787514988743 -0.799147013999334 EQFYK(ub)IAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQFYKIAK 8 1 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 1 25788600.0 10281000.0 5409600.0 10098000.0 True False 15597028.641778404 4444214.614602283 8102125.873889363 1.0 0.2849398251855454 0.5194659867576894 23.894767874576214 -10.159123859352057 5.2774884990930415 1.000021819240945 0.40220290597181835 0.8965114936262345 0.09574490453186295 2.4581114271670198e-05 3.916656139619547e-06 0.09270798162102194 0.03090153506120184 6.932280714645716e-11 10.159123859352057 -0.5978189132691265 EQFYK(ub)IAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQFYKIAK 8 1 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 1 42306800.0 14765000.0 19882000.0 7659800.0 True False 12277751.700405939 19774891.71973197 9261428.765086344 1.0 1.610628085847196 0.7543261169534918 23.549543063059584 -6.715209446673764 1.7763719437904193 1.3733777515343149 0.7559876954042564 0.48993603098212746 0.2571158538914349 0.36469188943590736 2.246250861079063 0.11504260511223652 0.2904597163837521 1.9265955522046058e-07 6.715209446673764 -0.6173900561300585 EQFYK(ub)IAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQFYKIAK 8 1 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 1 20979200.0 10281000.0 5232200.0 5466000.0 True False 13308957.168807723 4941023.470526558 4471244.085896187 1.0 0.3712554941650021 0.33595750810405095 23.665894196668663 -13.744157493471082 0.4121774487673175 9.999978975393518 0.3344315326668696 0.9998502830850992 0.0037325939154935163 22.96113522200032 0.21275627757710158 184.1737616826785 0.00874328905580528 1.8023640092283422e-14 13.744157493471082 -9.665547442726648 EQGK(ub)TGEVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQGKTGEVIK 10 1 A0A494C105;Q9H3U5-4;Q9H3U5-3;Q9H3U5;Q9H3U5-5;Q9H3U5-6;H7C4F4 A0A494C105 MFSD1 Major facilitator superfamily domain-containing protein 1 1 23027600.0 7230300.0 9329000.0 6468300.0 True False 9478993.318324806 7937149.56415718 5799022.3643148355 1.0 0.8373409810104063 0.6117761844081223 23.176302420454274 -6.966529128082215 0.33075911955896714 1.0272388665847865 0.4144857390809136 0.9999412831546619 0.0012197622657549067 0.0774458288030117 0.013050723372652187 0.0032825046922453837 0.019662272256581754 1.0801171751146048e-07 6.966529128082215 -0.6127531275038729 EQGK(ub)TGEVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQGKTGEVIK 10 1 A0A494C105;Q9H3U5-4;Q9H3U5-3;Q9H3U5;Q9H3U5-5;Q9H3U5-6;H7C4F4 A0A494C105 MFSD1 Major facilitator superfamily domain-containing protein 1 1 15486200.0 4760800.0 5505500.0 5219900.0 True False 4609671.009930167 7703874.8608032195 3852651.5963566545 1.0 1.671241796693844 0.8357758260963224 22.13623235918074 -6.692856783041795 1.8564978419426024 1.4197074938491367 0.8385816423377618 0.383676325028776 0.2837276116907214 0.4105837032645172 2.745878312186514 0.12216784472443933 0.31696545234400986 2.028351497161605e-07 6.692856783041795 -0.581125851511375 EQGK(ub)TGEVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQGKTGEVIK 10 1 A0A494C105;Q9H3U5-4;Q9H3U5-3;Q9H3U5;Q9H3U5-5;Q9H3U5-6;H7C4F4 A0A494C105 MFSD1 Major facilitator superfamily domain-containing protein 1 1 14745500.0 4294000.0 5905400.0 4546100.0 True False 6514311.933449719 4851535.230899209 3647561.3423735835 1.0 0.7447502177455647 0.559930408558434 22.63518137319466 -7.385251639282235 0.11756019390093715 1.3758236839398696 1.8836796753869275e-10 0.9999967318790121 0.00032611656646409123 0.1207902595691309 0.008188458760947918 0.03515384724577527 0.05688485246736609 4.118588103614641e-08 7.385251639282235 -1.3758236837515017 EQGK(ub)TGEVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQGKTGEVIK 10 1 A0A494C105;Q9H3U5-4;Q9H3U5-3;Q9H3U5;Q9H3U5-5;Q9H3U5-6;H7C4F4 A0A494C105 MFSD1 Major facilitator superfamily domain-containing protein 1 1 20521300.0 7230300.0 5715200.0 7575800.0 True False 9903537.301510628 5462683.566360958 5786552.068498576 1.0 0.5515891342710156 0.5842914397480917 23.239512481977165 -10.047170275088407 5.253188975113642 1.0000042672593754 0.567940287008665 0.9957217266944829 0.013350660308350026 6.6723297889051e-07 1.2104296815665278e-07 0.012926848739175949 0.004308907085811565 8.970770059763247e-11 10.047170275088407 -0.43206398025071047 EQGK(ub)TGEVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQGKTGEVIK 10 1 A0A494C105;Q9H3U5-4;Q9H3U5-3;Q9H3U5;Q9H3U5-5;Q9H3U5-6;H7C4F4 A0A494C105 MFSD1 Major facilitator superfamily domain-containing protein 1 1 14758600.0 4760800.0 6151800.0 3846000.0 True False 3958816.139200312 6118659.032363313 4650180.818105186 1.0 1.5455779751366006 1.1746392493601714 21.916637634615018 -10.4937199850726 5.725595418709878 0.9995453481411837 1.360108612248386 0.5568579150590981 0.1514351006650717 0.0008799544666093327 7.78090360846614e-05 0.14680622518702036 0.04887546857558873 3.2083372595236935e-11 10.4937199850726 0.3605632641072024 EQGK(ub)TGEVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQGKTGEVIK 10 1 A0A494C105;Q9H3U5-4;Q9H3U5-3;Q9H3U5;Q9H3U5-5;Q9H3U5-6;H7C4F4 A0A494C105 MFSD1 Major facilitator superfamily domain-containing protein 1 1 9380000.0 4294000.0 2677900.0 2408100.0 True False 5558667.647394265 2528872.5109367133 1969850.5091925738 1.0 0.45494220402296803 0.3543745793321499 22.406307695287108 -13.999999999999998 0.23767858829286753 4.567607437832563 0.30891819981817187 0.9995211873865762 0.006206415383091622 13.542600148842018 0.15431422163021724 22.900628728743893 0.04982047419399306 1.0000000000000041e-14 13.999999999999998 -4.258689238014391 EQGK(ub)TISNDDDVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQGKTISNDDDVQK 14 1 Q9Y6Q9-4;Q9Y6Q9-2;Q9Y6Q9-3;Q9Y6Q9-5;Q9Y6Q9 Q9Y6Q9-4 NCOA3 Nuclear receptor coactivator 3 1 4466490.0 750290.0 1313800.0 2402400.0 True False 1138244.7835463395 1079342.125233747 1927564.5869906736 1.0 0.9482513259326574 1.6934534775420738 20.118379416979927 -6.890246694858594 1.0208878478729206 0.9601960170158191 1.7578666733778985 0.9810569132552559 0.04676136773074006 0.11894461091598361 0.22066358336079792 0.03488839360349486 0.08705779773227794 1.2875179874916043e-07 6.890246694858594 0.7976706563620793 EQGNAYYAKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQGNAYYAKK 10 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;A0A6I8PR89;A0A6I8PU89;K7EK03;K7EIH8;K7ESP1;K7ELJ8 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 2877220.0 874160.0 948860.0 1054200.0 True False 1197360.575285746 906936.2277395822 805219.6719305163 1.0 0.7574462083179454 0.6724955611122851 20.19142624277664 -13.999999999999998 0.14625845616075017 2.1666204746929085 0.5748895626639958 0.9995792026880627 0.002846582506822178 11.945651460936734 0.12023897478962588 3.9655994050744985 0.087677141862299 1.0000000000000041e-14 13.999999999999998 -1.5917309120289127 EQGNVK(ub)AAGASDVVLYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQGNVKAAGASDVVLYK 17 1 Q9NSD9 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 1 6497700.0 2576500.0 2454000.0 1467200.0 True False 3529101.6772944555 2345574.1657072 1120677.5779325115 1.0 0.6646377407594011 0.31755321336949005 21.75086956566888 -7.301854766448617 0.28762266567730393 1.0859039597828153 1.9599654049485546e-17 0.9998873114592358 0.002957696266516812 0.10497936373280471 0.019746205609047243 0.013966758128446588 0.048642648501585756 4.990513486224436e-08 7.301854766448617 -1.0859039597828153 down EQGNVK(ub)AAGASDVVLYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQGNVKAAGASDVVLYK 17 1 Q9NSD9 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 1 4827900.0 1399800.0 2203900.0 1224200.0 True False 1163995.72165447 2192027.1532600997 1480174.5599387325 1.0 1.8831917613446338 1.2716323027672773 20.150654324856262 -10.146427426206321 5.860674399409836 0.9999942591770642 1.577412032055973 0.5430853589132605 0.24966810348127352 1.8727800251154292e-05 2.72782912334994e-06 0.2417425065342605 0.08058003390517113 7.137934752824658e-11 10.146427426206321 0.5774177728789088 EQGNVK(ub)AAGASDVVLYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQGNVKAAGASDVVLYK 17 1 Q9NSD9 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 1 14930400.0 3760600.0 4195200.0 6974600.0 True False 4868170.832508349 3961733.4321228163 5705294.365439362 1.0 0.81380328842764 1.1719585367343572 22.214948364920645 -6.765439805108146 1.5920642653530943 0.8925794792291764 1.1736271717375308 0.7127357628144555 0.07838822623463616 0.27387976085187854 1.3692909612123896 0.03882773207622443 0.09281236758960423 1.7161695613638109e-07 6.765439805108146 0.2810476925083545 EQGSK(ub)TFMCTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQGSKTFMCTGR 12 1 A0A0A0MTI1;Q15392;Q15392-2;A0A3B3IRV7;A0A3B3ISR5;A0A3B3ITT9 A0A0A0MTI1 DHCR24 Delta(24)-sterol reductase 1 6306260.0 920310.0 801950.0 4584000.0 True False 1206535.3222947188 682302.1859766163 4109691.652832931 1.0 0.5655053551842482 3.406192572146729 20.20243872155706 -6.867892896827397 1.1452634842160083 0.7571610330674491 3.5659728270298605 0.9625303598642612 0.2418391243451449 0.13888696153156524 0.3417999420513959 0.16408882143379294 0.3871060003853448 1.3555236624750387e-07 6.867892896827397 2.8088117939624113 up EQGSK(ub)TFMCTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQGSKTFMCTGR 12 1 A0A0A0MTI1;Q15392;Q15392-2;A0A3B3IRV7;A0A3B3ISR5;A0A3B3ITT9 A0A0A0MTI1 DHCR24 Delta(24)-sterol reductase 1 7254080.0 920310.0 876070.0 5457700.0 True False 1260573.4774426026 837362.3306239236 4168703.6648597806 1.0 0.6642709414470058 3.3069898260251103 20.26564878307995 -6.87501875358938 1.1072560310361188 0.8029601466031894 3.477232683057405 0.9694380023106423 0.20535761651147588 0.1321313478237893 0.29975950969825255 0.14345599544642937 0.3429120161674121 1.3334638496370268e-07 6.87501875358938 2.674272536454216 up EQGVLSFWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQGVLSFWR 9 0 P05141;P12236 P05141;P12236 SLC25A5;SLC25A6 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed;ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed 0 79308000.0 17283000.0 20942000.0 41083000.0 False True 22658180.368810106 17817535.23127663 36832125.25596323 1.0 0.7863621412336881 1.6255553030491419 24.433528670193347 -6.8392046063365655 1.2861382828170853 0.8863372857147173 1.6527160287693772 0.9230700432847547 0.09876622651349234 0.16972935247465135 0.5457279781529454 0.06022446770147969 0.13871315879499005 1.4480894638352185e-07 6.8392046063365655 0.7663787430546599 EQGVLSFWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQGVLSFWR 9 0 P05141;P12236 P05141;P12236 SLC25A5;SLC25A6 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed;ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed 0 36076100.0 11502000.0 4195100.0 20379000.0 False True 11136875.305876492 5870225.307157499 15041128.543104708 1.0 0.5270980545198357 1.350569897749335 23.4088411739933 -6.750981124568217 1.646428589177971 0.7222575025146052 1.3523095746893916 0.653121152610181 0.19872550041323697 0.2983237464242231 1.59139988639213 0.09534120530008265 0.23120521996297208 1.7742665928997982e-07 6.750981124568217 0.6300520721747864 EQGVLSFWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQGVLSFWR 9 0 P05141;P12236 P05141;P12236 SLC25A5;SLC25A6 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed;ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed 0 63534000.0 17283000.0 19235000.0 27016000.0 False True 23672992.155513365 18385134.09836103 20635377.21198523 1.0 0.7766290791457552 0.8716843682634904 24.49673873171624 -10.117436513067219 4.531514889229583 1.0000163285335801 0.8241567236997746 0.8202365372949791 0.03880615930715712 54118148.866892755 0.19781783553456825 9944.354662450156 0.013284380510320735 7.63068431453828e-11 10.117436513067219 -0.17585960483380558 EQGVLSFWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQGVLSFWR 9 0 P05141;P12236 P05141;P12236 SLC25A5;SLC25A6 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed;ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed 0 36236000.0 11502000.0 12781000.0 11953000.0 False True 9564422.624996219 12712146.216170141 14452317.035572356 1.0 1.329107538906476 1.511049605629286 23.189246449427575 -11.109617117208382 0.09962026549191515 6.802722769724259e-17 1.9759141232730124 0.999888208677738 0.002236201257733328 3.5782312187135443 0.06227169135328169 1.1200374985461374 0.30829892105873763 7.769317735327157e-12 11.109617117208382 1.9759141232730124 EQGVTFPAIGSQAAEQAK(ub)ASPALVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQGVTFPAIGSQAAEQAKASPALVAK 26 1 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 151940000.0 29312000.0 89280000.0 33348000.0 True False 44468446.99424264 73347286.45217608 26756753.183052376 1.0 1.6494231620382966 0.6017019930225266 25.406278685432827 -6.739067981980297 1.6903475145366933 1.386820436859309 0.601238549174265 0.6006834937739551 0.2728649602180711 0.31948756163509656 1.7920974427990117 0.12772918279737674 0.3137282551672012 1.8236102224370493e-07 6.739067981980297 -0.7855818876850439 EQGVTFPAIGSQAAEQAK(ub)ASPALVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQGVTFPAIGSQAAEQAKASPALVAK 26 1 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 39833000.0 11157000.0 16910000.0 11766000.0 True False 9277539.83890477 16818902.4736278 14226216.20016267 1.0 1.8128623283404084 1.5334039462170717 23.14531086037141 -10.130882294668087 4.420323469858703 0.9999226264425166 1.6731331370339702 0.8855287849659293 0.11408840741911874 17218277.165863767 19731190.766153798 13155.113789779163 0.039055499829544045 7.398057548852969e-11 10.130882294668087 0.6732105105914535 EQGVTFPAIGSQAAEQAK(ub)ASPALVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQGVTFPAIGSQAAEQAKASPALVAK 26 1 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 101590000.0 29312000.0 42881000.0 29397000.0 True False 37944961.82590137 40494634.654571556 24047047.63869196 1.0 1.0671939753258566 0.6337349276835313 25.177405007525277 -6.867309272870454 1.1481590437384206 1.0374530936955682 0.6096065057559249 0.9619271917648167 0.03716740925796702 0.1394650049540005 0.3452921463431496 0.025160480276198324 0.059308893734406766 1.3573464991055667e-07 6.867309272870454 -0.42784658793964325 EQGVTFPSGDIQEQLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQGVTFPSGDIQEQLIR 17 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 5750400.0 1649400.0 1010600.0 3090400.0 False True 1597040.699835913 1414137.85020938 2280931.5299872817 1.0 0.8854738957840428 1.4282237955624015 20.606969648950738 -6.85157601430934 1.2273841465154356 0.9387894596587001 1.4505985424888146 0.9425750365492088 0.055975824542194914 0.1557344057637861 0.45066329670805516 0.03567040106647977 0.08263476781095697 1.4074208667509013e-07 6.85157601430934 0.5118090828301145 EQGYDVIAYLANIGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQGYDVIAYLANIGQK 16 0 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 0 13232800.0 3432300.0 7393100.0 2407400.0 False True 4499778.538440486 6290078.298078094 2158305.341411429 1.0 1.3978639713807075 0.47964701439716745 22.10142256868741 -6.788945845746392 1.500575761028331 1.2226704252387706 0.47016711908055114 0.79788404185595 0.16902628349187113 0.23692471556814107 1.0539523049142487 0.08866774043142692 0.20775042901617524 1.6257514658283962e-07 6.788945845746392 -0.7525033061582194 down EQGYDVIAYLANIGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQGYDVIAYLANIGQK 16 0 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 0 33061700.0 19203000.0 3361700.0 10497000.0 False True 18593411.276190765 4704044.3410339095 7747520.796750096 1.0 0.2529952288560159 0.4166809780984596 24.148288145590822 -10.37846167320274 8.722129875263784 1.000002522257082 0.3348381035091489 0.9565551505491022 0.06682442730152421 3.2775251986460482e-06 2.334617104760047e-07 0.06470271920437039 0.021567491171554307 4.183486065848642e-11 10.37846167320274 -0.6651644187479332 EQGYDVIAYLANIGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQGYDVIAYLANIGQK 16 0 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 0 21464700.0 3432300.0 4063400.0 13969000.0 False True 4701314.064419865 3883865.552133099 10669809.900585627 1.0 0.826123398461439 2.2695377833478703 22.164632630210303 -6.876805808501024 1.097511737837079 0.8961904871588969 2.365745929229858 0.971013880412583 0.10953691183503318 0.130494562183837 0.28973428946577956 0.07709264166492544 0.1849997532449339 1.3279881248576466e-07 6.876805808501024 1.469555442070961 up EQGYDVIAYLANIGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQGYDVIAYLANIGQK 16 0 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 0 27517300.0 19203000.0 3365000.0 4949300.0 False True 15968145.33714157 3346872.0770997936 5984175.747022352 1.0 0.2095967945203404 0.3747570942445824 23.9286934210251 -10.278505756560731 8.240000511130045 1.0000008031779208 0.2921769445484746 0.9607678903624733 0.06742641001492103 9.948344645957791e-07 8.724769712958744e-08 0.06528541469021983 0.021761780256861846 5.266162345647566e-11 10.278505756560731 -0.7078238586294463 EQIEK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQIEKLR 7 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 21007800.0 6256500.0 7534500.0 7216800.0 True False 8202332.088032191 6410381.969250975 6470074.764433837 1.0 0.7815316303279402 0.7888091697572395 22.967602724603342 -10.7044424368221 6.699679046080444 1.002248812811363 0.78517040004259 0.9991400560042641 0.002971043030794804 0.00010072095586520006 4.443319133954288e-06 0.002903329402889063 0.0009589000149278202 1.974956630941612e-11 10.7044424368221 -0.21707841276877293 EQIEK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQIEKLR 7 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 32599500.0 5841400.0 7875100.0 18883000.0 True False 5655967.954420709 11019668.498103982 13936975.822142724 1.0 1.9483258368695318 2.4641185972861765 22.431342515474086 -9.23344679700455 0.18045347384194044 1.8014667517917416e-20 3.091521852314423 0.9996545837195203 0.011269352266841216 0.6760689377656883 0.06556306727028142 0.7019505130407945 0.327751983891246 5.841887684181655e-10 9.23344679700455 3.091521852314423 EQIEK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQIEKLR 7 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 23406400.0 6256500.0 4157900.0 12992000.0 True False 8569697.12555513 3974190.229663388 9923557.178639034 1.0 0.4637492050695954 1.15798225226031 23.030812786126234 -6.700469657736322 1.82941360356742 0.6671530358265925 1.155918318757676 0.4196618486581164 0.22634013176683354 0.3945706273664858 2.5676806063117272 0.09869593487619172 0.2536522217825544 1.993105750917361e-07 6.700469657736322 0.48876528293108357 EQIEK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQIEKLR 7 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 34100500.0 5841400.0 8461100.0 19798000.0 True False 4857382.917897144 8415518.374903148 23937670.264390666 1.0 1.7325210956492576 4.92810031018797 22.211747790908362 -6.942887164853826 0.6321323581676461 0.965134619278964 5.868342001631427 0.9985181470578567 0.065652595288642 0.08647381397044668 0.04879430297312387 0.06540389138529958 0.2717327341292562 1.1405460772264437e-07 6.942887164853826 4.903207382352463 EQIK(ub)WSLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQIKWSLLR 9 1 F8VVA7;P61923;P61923-4;P61923-3;P61923-5;F8VYK5;F8W651;P61923-2 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 8215700.0 2415900.0 2766800.0 3033000.0 True False 2339208.5768968016 3871597.6686713872 2238566.31195037 1.0 1.6550886940605596 0.9569759336809787 21.157589075494517 -6.660550204933408 1.9716289077622093 1.421489872904133 0.9599219664238932 0.23776692439847102 0.2788865879152591 0.48306892522028494 3.610685167093631 0.11427632489793757 0.3090451294706455 2.184991717538672e-07 6.660550204933408 -0.4615679064802398 EQIQK(ub)STGAP ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQIQKSTGAP 10 1 E7EWR4;P33240-2;P33240 E7EWR4 CSTF2 Cleavage stimulation factor subunit 2 1 2860880.0 2239500.0 0.0 621380.0 True False 2936006.18734885 0.0 557085.5582978458 1.0 0.0 0.1897426377023006 21.485423577848657 -10.363342449489812 5.241548898732485 1.0004165226703527 0.09487131885110726 0.9680928871207627 0.07746210747021978 0.00037720548119244784 4.581699589792911e-05 0.07503495395996156 0.02500078768283571 4.331691815190049e-11 10.363342449489812 -0.9055452038192455 EQIQK(ub)STGAP ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQIQKSTGAP 10 1 E7EWR4;P33240-2;P33240 E7EWR4 CSTF2 Cleavage stimulation factor subunit 2 1 4652070.0 2239500.0 1712400.0 700170.0 True False 3067503.6702118916 1636740.5058504515 534804.2664537946 1.0 0.5335740986211734 0.174345110536364 21.54863363937155 -8.02421991911622 0.3337054156651821 1.1002533961187622 8.824155979562561e-21 0.9987267238132278 0.012061488022030957 0.09659906932933747 0.06832551390473356 0.05593608406225005 0.08749473022414914 9.457581247447206e-09 8.02421991911622 -1.1002533961187622 down EQISDIDDAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQISDIDDAVR 11 0 P53999 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 0 42999700.0 10984000.0 4008700.0 28007000.0 False True 10635318.93233763 5609394.815094341 20671126.50800989 1.0 0.5274308039826129 1.9436301477671247 23.342359961751093 -6.816745852225907 1.3859705328834655 0.7444221550814196 1.9724228586972397 0.8767174316816879 0.206711067226052 0.19774476813486316 0.7472588556030173 0.1172299760444556 0.2704487900494141 1.5249448857186877e-07 6.816745852225907 1.22800070361582 EQIVPKPEEEVAQKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQIVPKPEEEVAQKK 15 2 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 14472500.0 8090500.0 2948400.0 3433600.0 True False 10606723.84851345 2508510.2127731824 3078324.009416914 1.0 0.23650188772707176 0.2902238290901055 23.338475776885087 -10.197219541259985 8.093790080839911 1.0000002342702268 0.2633628584085894 0.9960269087722093 0.021931890721858426 9.270608531207971e-08 9.187514200363806e-09 0.021235468523835434 0.00707848729304989 6.350098453303683e-11 10.197219541259985 -0.7366373758616374 EQIVPKPEEEVAQKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQIVPKPEEEVAQKK 15 2 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 30963300.0 8772200.0 9156200.0 13034900.0 True False 8493731.312659508 12812318.40895221 9620668.65138209 1.0 1.5084440438863485 1.1326787129518607 23.017967041086397 -10.344054532672834 10.171834461384277 0.9999999318066338 1.3205613784191046 0.49247555468534876 0.15340555396959235 2.3708057530202018e-07 1.523160860317068e-08 0.1485343199212828 0.04951142964499618 4.5284071488219435e-11 10.344054532672834 0.32056144661247077 EQIVPKPEEEVAQKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQIVPKPEEEVAQKK 15 2 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 44080200.0 19437000.0 14696100.0 9947100.0 True False 29487350.03504007 12073466.133846603 7981051.325031186 1.0 0.40944561378013283 0.27066017514450214 24.813592840524798 -13.999999999999998 0.203438625111424 4.326643428638627 0.18352002832605366 0.9994873997562468 0.0071594192123347 12.601016399949783 0.1430019328160392 16.704792754064826 0.0861581738124556 1.0000000000000041e-14 13.999999999999998 -4.1431234003125725 EQIVPKPEEEVAQKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQIVPKPEEEVAQKK 15 2 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 27228900.0 8090500.0 7255200.0 11883200.0 True False 11081776.487541554 6934641.2742619645 9076632.902186224 1.0 0.6257698196726927 0.8190593730518235 23.40168583840798 -10.093711375429622 4.793842275982414 1.00001255428091 0.7224145963592337 0.7333254652907721 0.07891012974196296 1.0588405974692868e-05 2.001790250833757e-06 0.0764078585728249 0.025468134859995082 8.059138596194452e-11 10.093711375429622 -0.2775979579216763 EQIVPKPEEEVAQKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQIVPKPEEEVAQKK 15 2 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 34835600.0 8772200.0 15926700.0 10136700.0 True False 7294472.974351568 15840899.705897568 12256237.103194715 1.0 2.1716304607058636 1.6802087205325777 22.798372316520673 -10.39796276039306 5.4120695249819555 0.9994891353362733 1.925919590619232 0.8255845324767613 0.20062208532256043 0.0012372899660581793 0.00013763548999151185 0.19435070338344648 0.0647504996113009 3.9997904543941953e-11 10.39796276039306 0.9264304552829586 EQIVPKPEEEVAQKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQIVPKPEEEVAQKK 15 2 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 75737200.0 19437000.0 7629200.0 48671000.0 True False 25161579.66055012 7204628.313394216 39813377.4066325 1.0 0.28633449928782007 1.5823083424708175 24.584719162617247 -6.75720088950332 1.622918156793346 0.5840183199700575 1.586411177315972 0.6794481762404606 0.30006274751661616 0.2876571016970301 1.4925738284331607 0.14592343361902296 0.351665474726446 1.749037457659175e-07 6.75720088950332 1.0023928573459144 EQK(ub)YEDGIALLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQKYEDGIALLR 12 1 Q9UJX3;Q9UJX3-2;H0YIW2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 10113700.0 2208600.0 2943100.0 4962000.0 True False 2895495.988112826 2504000.952113948 4448579.838864965 1.0 0.8647917187224149 1.5363792100310871 21.465379067210815 -6.854319668809914 1.2140037702862065 0.9274839690652856 1.5655586755017883 0.9463653382976123 0.06716660309237595 0.15276936360559865 0.4310941813441258 0.043239009211474444 0.10037802913921282 1.3985575148879175e-07 6.854319668809914 0.6380747064365027 EQK(ub)YEDGIALLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQKYEDGIALLR 12 1 Q9UJX3;Q9UJX3-2;H0YIW2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 56810700.0 5897700.0 17635000.0 33278000.0 True False 8947242.079624217 14487896.467116108 26700588.71373445 1.0 1.6192583522591577 2.9842255832711158 23.093011620280976 -6.958099822227595 0.46143345858342355 0.9607780921755044 3.6978628447186503 0.9996931051615635 0.014521118960882191 0.08038699970825351 0.023693049229227874 0.01858338120721197 0.11274279960423167 1.1012861507371439e-07 6.958099822227595 2.737084752543146 EQK(ub)YEDGIALLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQKYEDGIALLR 12 1 Q9UJX3;Q9UJX3-2;H0YIW2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 44023700.0 5897700.0 12033000.0 26093000.0 True False 7634688.911047309 11363352.972142896 21344341.736789096 1.0 1.4883845438286625 2.7957054944182564 22.864137942373425 -6.953981117529996 0.5132811249819522 0.9765743702609044 3.3651915756729363 0.9994778048926084 0.017323328366006596 0.08192543522262445 0.029643105706795077 0.019841911646393397 0.10792174367126442 1.1117800647535823e-07 6.953981117529996 2.388617205412032 EQLAIAEFAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQLAIAEFAR 10 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 32573600.0 6718600.0 10928000.0 14927000.0 False True 8808149.663014952 9297584.997010374 13382497.229894675 1.0 1.0555661918473684 1.5193312718205976 23.070407551879395 -6.929315121555541 0.7523843568497319 0.992765867782043 1.6129030324765554 0.9964021551273555 0.013965363953762265 0.09299451470801827 0.07943115869932696 0.012671787305295414 0.04212169053487962 1.1767518193830466e-07 6.929315121555541 0.6201371646945124 EQLAIAEFAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQLAIAEFAR 10 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 22989200.0 6414300.0 3013900.0 13561000.0 False True 6210681.557510301 4217365.987280867 10008967.278720388 1.0 0.6790504308147943 1.6115730916226079 22.566320167187946 -6.813785984561987 1.398581225961284 0.8258530632611923 1.6293361260659476 0.8694834355580987 0.13974475238491518 0.20167908472429397 0.7767574037674608 0.0785512502261247 0.18141197870056083 1.535373411159475e-07 6.813785984561987 0.8034830628047552 EQLAIAEFAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQLAIAEFAR 10 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 35517600.0 6718600.0 13382000.0 15417000.0 False True 9202647.983338073 12790738.991643744 11775822.123081729 1.0 1.3898976701925487 1.2796123620508506 23.133617613402286 -10.324369866099758 5.353073726704857 0.9999190938721199 1.3347550161215564 0.9247243203394231 0.04502378851217822 4.348911999534322e-05 5.48894089098508e-06 0.04360458900171972 0.01453136525756208 4.738382698785821e-11 10.324369866099758 0.3348359222494366 EQLAQAMFDHIPVGVGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQLAQAMFDHIPVGVGSK 18 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 10841100.0 2675400.0 1590500.0 6575200.0 False True 2590470.891439919 2225594.9443479287 4852957.868228186 1.0 0.8591468646500895 1.873388303363895 21.30478294175169 -6.871771033357295 1.1246201937427585 0.9194095227687709 1.9348380816406396 0.9664222028047714 0.0822060775695258 0.13517138377318097 0.3184352207170318 0.05666341787110933 0.1345876809697233 1.3434730738537281e-07 6.871771033357295 1.0154285588718688 EQLDNQLDAYMSK(ub)TK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQLDNQLDAYMSKTK 15 1 X6R700;Q9Y3Y2-4;Q9Y3Y2;Q9Y3Y2-3 X6R700 CHTOP Chromatin target of PRMT1 protein 1 9949900.0 3912200.0 3590300.0 2447400.0 True False 5128932.085798688 3054641.2348797903 2194166.525118522 1.0 0.5955706146582979 0.4278018286094817 22.29022703747502 -13.999999999999998 0.12075049575118771 2.9265550963597873 0.16272057326755954 0.9996892671701977 0.004233561692998823 11.960939730607125 0.10704005128427628 5.524355407640527 0.23524314352123118 1.0000000000000041e-14 13.999999999999998 -2.763834523092228 EQLDNQLDAYMSK(ub)TK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQLDNQLDAYMSKTK 15 1 X6R700;Q9Y3Y2-4;Q9Y3Y2;Q9Y3Y2-3 X6R700 CHTOP Chromatin target of PRMT1 protein 1 23540400.0 8736200.0 8237100.0 6567100.0 True False 13253454.101770697 6767125.148243959 5269109.806537819 1.0 0.5105933212791565 0.39756502464016924 23.659865066610287 -13.999999999999998 0.20590402108162853 3.7838506286703937 0.3282866306175718 0.9994881247184211 0.005915297805980937 12.653896054957777 0.14385162126482012 14.223698894875037 0.06892660327891902 1.0000000000000041e-14 13.999999999999998 -3.455563998052822 EQLDNQLDAYMSK(ub)TK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQLDNQLDAYMSKTK 15 1 X6R700;Q9Y3Y2-4;Q9Y3Y2;Q9Y3Y2-3 X6R700 CHTOP Chromatin target of PRMT1 protein 1 10185200.0 3912200.0 2814600.0 3458400.0 True False 5358646.063229718 2690241.6653624605 2641597.147983776 1.0 0.5020375732262901 0.492959810521924 22.35343709899791 EQLEEEEEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQLEEEEEAK 10 0 P35579 P35579 MYH9 Myosin-9 0 6736680.0 1679400.0 620580.0 4436700.0 False True 1626088.3662570824 868380.8302819479 3274595.1718530226 1.0 0.5340305289070976 2.0137867288174878 20.6329742290107 -6.822077226531704 1.3631020250748298 0.7493681331227339 2.0474887325639717 0.8890431162737389 0.20577472238714914 0.19079823260247286 0.6960607933258757 0.1186181879368217 0.2732236744619334 1.5063391841410273e-07 6.822077226531704 1.298120599441238 up EQLELFQNIRPLFINKPLIVVANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQLELFQNIRPLFINKPLIVVANK 24 2 Q9BZE4;Q9BZE4-2;Q9BZE4-3 Q9BZE4 GTPBP4 Nucleolar GTP-binding protein 1 0 18888700.0 8236600.0 4820900.0 5831200.0 False True 7975133.641486898 6745910.510661376 4303833.787749751 1.0 0.8458680210158405 0.5396566353899163 22.92707726403804 -6.960175408189026 0.43295630810008434 1.0117885987738688 0.3619358907692718 0.9997766445857965 0.002859321632396264 0.07963854492456378 0.02090038308862179 0.004004769806375716 0.025408055935620035 1.0960354264848568e-07 6.960175408189026 -0.649852708004597 EQLELFQNIRPLFINKPLIVVANK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQLELFQNIRPLFINKPLIVVANK 24 2 Q9BZE4;Q9BZE4-2;Q9BZE4-3 Q9BZE4 GTPBP4 Nucleolar GTP-binding protein 1 0 65948000.0 15384000.0 22173000.0 28391000.0 False True 23338652.721050393 18216054.911560282 22779506.405782655 1.0 0.7805101318093755 0.9760420482728459 24.47621794467578 -10.290217174407053 6.92798766680904 1.0000014723438266 0.8782760900857076 0.3406824929479413 0.07982557062733468 1.8153393677622708e-06 1.8602926539797545e-07 0.07729171157629557 0.025763592136764272 5.126049853317581e-11 10.290217174407053 -0.12172538225811902 EQLELFQNIRPLFINKPLIVVANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQLELFQNIRPLFINKPLIVVANK 24 2 Q9BZE4;Q9BZE4-2;Q9BZE4-3 Q9BZE4 GTPBP4 Nucleolar GTP-binding protein 1 0 21454600.0 8236600.0 3061000.0 10157000.0 False True 6849097.843248466 3044509.785439072 12280781.739338104 1.0 0.4445125263380802 1.7930510003509366 22.707482539472316 -6.7948544701062135 1.4769232459095054 0.6914880519096964 1.809366196804353 0.8166636158385696 0.23694459073605248 0.2281864827895588 0.9831276486427236 0.12624684797369642 0.2945591312581508 1.60378272016972e-07 6.7948544701062135 1.1178781448946566 EQLELFQNIRPLFINKPLIVVANK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQLELFQNIRPLFINKPLIVVANK 24 2 Q9BZE4;Q9BZE4-2;Q9BZE4-3 Q9BZE4 GTPBP4 Nucleolar GTP-binding protein 1 0 39838300.0 15384000.0 8954300.0 15500000.0 False True 19914891.263976082 8455985.333537698 12679159.04343047 1.0 0.42460615131922286 0.6366672494147994 24.24734426676823 -10.138695322377613 5.259842012233888 1.000013841482234 0.5306367003667065 0.8672301701331957 0.0865735807724882 1.4052597390355112e-05 2.301033743961787e-06 0.0838269786960058 0.027941503045960187 7.266155329996466e-11 10.138695322377613 -0.4693771411155274 EQLGYIVFSGPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQLGYIVFSGPR 12 0 A0A3B3ISG5;P14735;P14735-2 A0A3B3ISG5 IDE Insulin-degrading enzyme 0 6342200.0 1975300.0 1823500.0 2543400.0 False True 2589637.4288324094 1551440.9079473272 2280233.366015547 1.0 0.5990958003131835 0.8805222463299183 21.304318691853172 -10.181886215712101 5.479502922503431 1.00000855924306 0.7398090233215175 0.5326463896558169 0.11489186547777024 1.2013819583650756e-05 1.7937581739312692e-06 0.11124722928165694 0.03708119013415853 6.578301649706277e-11 10.181886215712101 -0.26019953592154255 EQLGYIVFSGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQLGYIVFSGPR 12 0 A0A3B3ISG5;P14735;P14735-2 A0A3B3ISG5 IDE Insulin-degrading enzyme 0 5002300.0 1975300.0 1367800.0 1659200.0 False True 2705621.79047535 1307366.0732902633 1267331.1322966355 1.0 0.4832035570871761 0.46840661054625027 21.367528753376064 EQLK(ub)ELTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQLKELTK 8 1 A0A087X2I1;P62333;H0YJC0;H0YJE9;H0YJT1 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 30913500.0 14822000.0 12558000.0 3533500.0 True False 19431785.536452167 10684395.350700598 3167887.3157253796 1.0 0.5498411523046967 0.16302605387357363 24.211915136737005 -7.883171858011643 0.3646358327706502 1.071372349895131 6.76116753185531e-20 0.9984602822120974 0.01342057211695518 0.10813422883884383 0.06811108197056533 0.04140539134716692 0.08227466423600042 1.3086639590360705e-08 7.883171858011643 -1.071372349895131 down EQLK(ub)ELTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQLKELTK 8 1 A0A087X2I1;P62333;H0YJC0;H0YJE9;H0YJT1 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 41599200.0 17014000.0 20127000.0 4458200.0 True False 16473899.88299273 28163816.0609184 3290463.6768668443 1.0 1.7096022351085225 0.19973799162539785 23.973678790364833 -6.778869148950597 1.5400661116396148 1.4023645660818937 0.18814009314902047 0.7634973478091159 0.29994463177037095 0.252300726441979 1.181861701723497 0.15340531848986835 0.3623476058246797 1.663913904917849e-07 6.778869148950597 -1.2142244729328733 EQLK(ub)ELTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQLKELTK 8 1 A0A087X2I1;P62333;H0YJC0;H0YJE9;H0YJT1 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 30580400.0 14822000.0 12295000.0 3463400.0 True False 20302093.949489005 11751766.245872043 2645416.250962007 1.0 0.578845033182788 0.1303026307307868 24.275125198259897 -7.70453923572495 0.4371599773684529 1.0336645701694167 4.9982756362512245e-20 0.9974825321682531 0.01781747839499896 0.11725101657173523 0.07419540900590765 0.02833470986147984 0.07573232777072493 1.9745164864325934e-08 7.70453923572495 -1.0336645701694167 down EQLK(ub)ELTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQLKELTK 8 1 A0A087X2I1;P62333;H0YJC0;H0YJE9;H0YJT1 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 42655700.0 17014000.0 23821000.0 1820700.0 True False 14147894.847999083 23692671.54490171 2201399.952034349 1.0 1.6746428920662024 0.15559911744365912 23.75408406579911 -6.785962303712729 1.5123195052288612 1.379044720803307 0.14116848120772385 0.7880135951927093 0.2861216758248028 0.2414224675179004 1.0908198001880378 0.148951416674209 0.34980084388508537 1.6369586014824237e-07 6.785962303712729 -1.2378762395955831 EQLLYLYAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQLLYLYAR 9 0 Q9BR61;A0A2R8Y544 Q9BR61 ACBD6 Acyl-CoA-binding domain-containing protein 6 0 15139700.0 3546500.0 6968600.0 4624600.0 False True 5380299.783879696 5724998.884079694 3710545.782965812 1.0 1.0640668947913972 0.6896540958708742 22.359255129590693 -6.862818179332744 1.171314213429022 1.035059598433672 0.6705139042022661 0.9569805954185283 0.03391270567660767 0.14393253882506007 0.37363182134497097 0.02255326477381935 0.052828115784472725 1.3714558163342491e-07 6.862818179332744 -0.3645456942314058 EQLVQK(ub)AR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQLVQKAR 8 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 124547000.0 32315000.0 52497000.0 39735000.0 True False 42365277.93890513 44664652.231703274 35623603.36503413 1.0 1.0542749724459277 0.8408679252950223 25.33637899815826 -6.839276684412042 1.2858144970245358 1.0288757659815029 0.8339514736313663 0.9231935554451157 0.025098002728525564 0.1696450726194838 0.5451532723316544 0.015307674725155275 0.035258110433047433 1.447849150303476e-07 6.839276684412042 -0.19492429235013653 EQLVQK(ub)AR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQLVQKAR 8 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 174741000.0 55914000.0 67881000.0 50946000.0 True False 54139040.67577621 94986237.29473862 37601714.25276083 1.0 1.7544868935448081 0.6945397218607386 25.690165987956465 -6.715546683714499 1.7751382714255806 1.4611924976236295 0.6965711288354101 0.4914624286568904 0.3176774591145258 0.3640698401896208 2.2394941205592467 0.14222659215480835 0.35895285260611215 1.9251000987369813e-07 6.715546683714499 -0.7646213687882194 EQLVQK(ub)AR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQLVQKAR 8 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 110447000.0 41212000.0 32163000.0 37072000.0 True False 62521617.00077539 26423261.35933403 29744702.950765166 1.0 0.42262600724172456 0.4757506983607969 25.89785175555027 -10.568347424163724 9.927899551517473 1.000028549578403 0.44918835377336214 0.9930716711492776 0.021688064330782072 1.370571649376198e-05 5.959237294834774e-07 0.02100045737659421 0.006999792663716181 2.70179613350987e-11 10.568347424163724 -0.5508401958050408 EQLVQK(ub)AR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQLVQKAR 8 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 113730000.0 32315000.0 40725000.0 40690000.0 True False 44262728.780038945 38925634.84043424 31079860.03685515 1.0 0.8794223924573858 0.7021677355525165 25.39958905968115 -6.965590314697926 0.34777275368059113 1.0175745047395204 0.5580548114016664 0.9999247991601371 0.0010607341723786162 0.07776121262027359 0.014156850912606387 0.0024472266644095927 0.015258300697730211 1.0824545874110301e-07 6.965590314697926 -0.45951969333785403 EQLVQK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQLVQKAR 8 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 167633800.0 55914000.0 74914000.0 36805800.0 True False 46494968.41019288 74510423.41273527 44501722.609208494 1.0 1.6025481027405257 0.9571298600872388 25.47057126339074 -6.66162425833691 1.9669654809713946 1.3873328259113478 0.9598053242192728 0.24256659403520697 0.2564520833346534 0.4806269335109911 3.576300963620359 0.10526950665512996 0.28437195842571 2.1795946923697156e-07 6.66162425833691 -0.427527501692075 EQLVQK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQLVQKAR 8 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 77795100.0 41212000.0 19654000.0 16929100.0 True False 53349746.40997024 18560237.622745484 13848177.507234745 1.0 0.34789739167863903 0.2595734457820541 25.66897807764272 -13.999999999999998 0.2817215353562452 6.365316689214402 0.23343216937765218 0.9996089936989043 0.006529272673730006 15.492154245765132 0.16816494281432787 47.939297302027484 0.03465547070990842 1.0000000000000041e-14 13.999999999999998 -6.13188451983675 EQLWLANEGLITR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQLWLANEGLITR 13 0 P46940;H0YLE8;A0A0J9YXZ5;A0A087WWP1 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 10581000.0 1951300.0 3113800.0 5515900.0 False True 2558173.1964160767 2649233.177497338 4945167.5802489435 1.0 1.0355957060330527 1.9330855264909248 21.286682511867376 -6.915260632463815 0.8591436271804491 0.9766182083662899 2.063132867732941 0.9927598843592123 0.03673417417839541 0.10104119235646448 0.12065894301646761 0.0308800868759713 0.08869466049982082 1.215456351819562e-07 6.915260632463815 1.0865146593666513 EQLWLANEGLITR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQLWLANEGLITR 13 0 P46940;H0YLE8;A0A0J9YXZ5;A0A087WWP1 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 5913000.0 1936700.0 1163000.0 2813300.0 False True 1875220.518595983 1627391.964964879 2076412.33280909 1.0 0.8678403146864783 1.1072896825829015 20.83862883020098 -6.756876570181622 1.6241395646702736 0.9229347260241428 1.1080336618884898 0.6780656121268331 0.05556498271747504 0.2882260726996723 1.4976983596398883 0.027002423640764654 0.06509506228958752 1.7503440791348374e-07 6.756876570181622 0.185098935864347 EQLWLANEGLITR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQLWLANEGLITR 13 0 P46940;H0YLE8;A0A0J9YXZ5;A0A087WWP1 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 5838400.0 1951300.0 1536800.0 2350300.0 False True 2672748.3418997354 1468899.094481997 1795207.5459479142 1.0 0.5495837641930528 0.6716709979031984 21.349892573390267 -10.286434217388448 8.333359566260725 1.00000044051953 0.6106273810481329 0.9313288948145291 0.049841904449629056 4.079222289312582e-07 3.4949121470580694e-08 0.04825927111873184 0.01608640548972289 5.170895756265416e-11 10.286434217388448 -0.3893730594713971 EQNDK(ub)TYCQPCFNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQNDKTYCQPCFNK 14 1 O60711;O60711-2;B7Z5P7 O60711 LPXN Leupaxin 1 23260100.0 2532500.0 5730600.0 14997000.0 True False 3841987.6505499296 4707929.656617842 12032836.376581402 1.0 1.2253890654604171 3.1319299984889493 21.873421451024385 -6.929073010563399 0.7543613822913833 0.9699877945652908 3.5142520469616536 0.9963528965388001 0.05775298615336947 0.09312213200445184 0.08005904548238993 0.05232842175481529 0.1733969336842038 1.1774080192464798e-07 6.929073010563399 2.5442642523963626 up EQNDK(ub)TYCQPCFNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQNDKTYCQPCFNK 14 1 O60711;O60711-2;B7Z5P7 O60711 LPXN Leupaxin 1 16978700.0 2532500.0 4506200.0 9940000.0 True False 3278371.173038184 4255426.0087318495 8131021.993012813 1.0 1.2980305719282523 2.480201772112797 21.644547773116834 -6.945067185682645 0.6106037395904595 0.9869349880284458 2.852925051117399 0.9987551015474851 0.02255345465475784 0.08552906590427457 0.04464063517807106 0.022911981766260615 0.09970494138326795 1.1348352422273948e-07 6.945067185682645 1.8659900630889532 up EQNIVFNAETYSNLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQNIVFNAETYSNLIK 16 0 P42704 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 4295000.0 0.0 1396300.0 2898700.0 False True 0.0 1953849.8716083053 2139443.5108640078 0.0 EQPEK(ub)EPELQQYVPQLQNNTILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQPEKEPELQQYVPQLQNNTILR 23 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 52231000.0 19955000.0 19247000.0 13029000.0 True False 19321539.44781474 26932427.47177906 9616314.038378289 1.0 1.3939069163986884 0.49769916441445305 24.203706710002624 -6.787231468347581 1.507309032907965 1.22095285194853 0.4888742540888396 0.7922335218418208 0.1671772068632215 0.23951390169357614 1.0750492876198934 0.08731287196816583 0.20484656402003604 1.6321818030106306e-07 6.787231468347581 -0.7320785978596904 down EQPEK(ub)EPELQQYVPQLQNNTILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQPEKEPELQQYVPQLQNNTILR 23 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 145862000.0 62890000.0 46471000.0 36501000.0 True False 95408727.87486085 38177886.97041982 29286561.351043396 1.0 0.4001508857815855 0.3069589334579115 26.50761791247405 -13.999999999999966 0.2621175152893297 5.440087601349196 0.2735824316672686 0.9995666847158793 0.006392720527317805 14.511734895372737 0.1620207713633318 34.172939475142314 0.040292747684935654 1.0000000000000778e-14 13.999999999999966 -5.166505169681928 EQPEK(ub)EPELQQYVPQLQNNTILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQPEKEPELQQYVPQLQNNTILR 23 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 47508700.0 19955000.0 20557000.0 6996700.0 True False 16593466.656390136 20446255.360754963 8459677.620914329 1.0 1.2321870880959718 0.5098197860696283 23.9841119854369 -6.820218381249557 1.3710738095168908 1.1251178066955385 0.4939943594709656 0.8848535838396663 0.10217615844707831 0.1931987989844331 0.7135991765760386 0.058563108167493896 0.13496113762413972 1.5128003584837175e-07 6.820218381249557 -0.6311234472245729 EQPEK(ub)EPELQQYVPQLQNNTILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQPEKEPELQQYVPQLQNNTILR 23 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 136006000.0 62890000.0 44964000.0 28152000.0 True False 81412344.74723454 42461713.87346738 23028624.863913186 1.0 0.5215635786599764 0.28286404150883315 26.2787442345665 -9.875037322306751 0.17220542364867064 1.6394918252341428 1.8285861416250368e-21 0.9996235827041237 0.005784988625838788 1.3731202758535614 0.07632130577663593 0.5820688434116974 0.17003982573041998 1.3334068372064015e-10 9.875037322306751 -1.6394918252341428 EQPFGEGVPLDGDDPEHIQWIFQK(ub)SLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQPFGEGVPLDGDDPEHIQWIFQKSLER 28 1 F8W8D4;Q8TBC4-2;Q8TBC4 F8W8D4 UBA3 NEDD8-activating enzyme E1 catalytic subunit 1 18165500.0 7792500.0 5830300.0 4542700.0 True False 6479809.016282643 5798891.016676063 5492557.566928344 1.0 0.8949169646982572 0.8476418908530319 22.627519861550997 -13.999999999925013 0.1078749863163806 1.509049176862252 0.7582028945129632 0.9997538566063127 0.0009989752341375525 12.02558241248062 0.09931217443023743 1.3387623977646936 0.07948849257554255 1.0000000001726643e-14 13.999999999925013 -0.7508462823492889 EQQEAIEHIDEVQNEIDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQQEAIEHIDEVQNEIDR 18 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 88772800.0 2109800.0 47636000.0 39027000.0 False True 2765968.2313322667 40528894.483673654 34988860.41341856 1.0 14.652697028321382 12.649769443145663 21.399353155761027 -9.295452686523632 12.288537997734068 1.0000372311981247 13.651233235733523 0.9815482447442212 0.817691762853437 0.0 0.0 0.791726585851892 0.2639088816126409 5.064625222196717e-10 9.295452686523632 12.651196004535398 EQQEAIEHIDEVQNEIDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQQEAIEHIDEVQNEIDR 18 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 73431000.0 23925000.0 10882000.0 38624000.0 False True 23165513.97088286 15227239.34888033 28507215.70483717 1.0 0.6573236133685493 1.230588526577411 24.46547535586474 -6.744783637892166 1.6690672247496972 0.7972533128319734 1.2312977403221403 0.6263197639876482 0.14397248817311273 0.30920245942591534 1.6929997669804144 0.06819002416414213 0.16646913927299992 1.799767321795939e-07 6.744783637892166 0.4340444274901669 EQQEAIEHIDEVQNEIDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQQEAIEHIDEVQNEIDR 18 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 105897800.0 2109800.0 63239000.0 40549000.0 False True 2889850.0752011864 60444891.87659239 30972161.332869027 1.0 20.916272575968954 10.717566838034944 21.46256321728392 -9.511340817653357 7.691238772437079 1.0000007899356627 15.816919707005901 0.7378260596426605 4.16360418246995 0.0 4.483937543375598e-16 4.031392234502842 1.3437974715733256 3.0807693317359217e-10 9.511340817653357 14.81691891707024 EQQEAIEHIDEVQNEIDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQQEAIEHIDEVQNEIDR 18 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 29255600.0 23925000.0 3651900.0 1678700.0 False True 19894697.557210416 3632226.489854604 2029708.408568169 1.0 0.18257259148622643 0.10202258178247821 24.245880631299016 -13.999999999999998 0.32761347602712304 9.771420442418059 0.08735554217581813 0.9997098669553826 0.006909720576451847 18.623762595542413 0.18290602928771307 112.41926353931972 0.026044844289575528 1.0000000000000041e-14 13.999999999999998 -9.684064900242241 EQQIVIQSSGGLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQQIVIQSSGGLSK 14 0 P38646;H0Y8S0 P38646 HSPA9 Stress-70 protein, mitochondrial 0 42530500.0 8713500.0 16169000.0 17648000.0 False True 11423482.881654033 13756648.22626836 15821954.251569722 1.0 1.2042429063697693 1.3850376820697632 23.445499242234693 -6.9725629838809144 0.18709760519934726 0.872721562515453 1.7214832771430826 0.9999960843496843 0.0003111881840298297 0.07547948733251969 0.005948538705717243 0.00654369796588411 0.019869902043687854 1.0652143689572245e-07 6.9725629838809144 0.8487617146276296 EQQIVIQSSGGLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQQIVIQSSGGLSK 14 0 P38646;H0Y8S0 P38646 HSPA9 Stress-70 protein, mitochondrial 0 29139700.0 6509400.0 3459300.0 19171000.0 False True 6302762.660065412 4840616.530011181 14149539.98232791 1.0 0.768015042146763 2.244974266916321 22.587552906244213 -6.866749460912141 1.1512251585566575 0.8710658617951229 2.326266260071996 0.9613259977008335 0.12753575142419785 0.14000570091401998 0.3488467320488444 0.08613857575051491 0.20285199320472955 1.359097266795512e-07 6.866749460912141 1.4552003982768729 up EQQIVIQSSGGLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQQIVIQSSGGLSK 14 0 P38646;H0Y8S0 P38646 HSPA9 Stress-70 protein, mitochondrial 0 34624500.0 8713500.0 13227000.0 12684000.0 False True 11935116.423483511 12642587.404160187 9688300.435179912 1.0 1.0592764205705323 0.811747459464847 23.508709303757584 -6.843506516463001 1.2661125831015867 1.0315328578899272 0.8030297067573029 0.930299200365979 0.027860054733443492 0.16474534529703297 0.5114976523149504 0.017244029514266023 0.039769964638815755 1.4338162018972908e-07 6.843506516463001 -0.22850315113262432 EQQIVIQSSGGLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQQIVIQSSGGLSK 14 0 P38646;H0Y8S0 P38646 HSPA9 Stress-70 protein, mitochondrial 0 18301400.0 6509400.0 6505800.0 5286200.0 False True 5412854.515314756 6470751.9640998095 6391519.979372752 1.0 1.1954416926950302 1.180803947582376 22.36795818167849 -10.078507636960678 4.582288799874654 0.9999887931079194 1.1881228201445102 0.9954797805950502 0.005975834441560706 4150845.543882632 0.01180058422568458 493.553617124546 0.002045687073774346 8.346268714418894e-11 10.078507636960678 0.18813402703659077 EQQIVIQSSGGLSKDDIENMVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQQIVIQSSGGLSKDDIENMVK 22 1 P38646;H0Y8S0 P38646 HSPA9 Stress-70 protein, mitochondrial 0 103473000.0 18765000.0 56473000.0 28235000.0 False True 28467876.905259397 46394951.92443704 22654339.874159876 1.0 1.6297299612064025 0.7957860696655789 24.762831567110222 -6.704742897147489 1.8139582831185053 1.3892183471715833 0.7980387749567495 0.4400149055281414 0.2655956448266399 0.38578804879291456 2.4710686593019724 0.11666607181487834 0.29828995625319354 1.973590758433971e-07 6.704742897147489 -0.5911795722148339 EQQIVIQSSGGLSKDDIENMVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQQIVIQSSGGLSKDDIENMVK 22 1 P38646;H0Y8S0 P38646 HSPA9 Stress-70 protein, mitochondrial 0 63333000.0 18765000.0 23741000.0 20827000.0 False True 24291662.41344976 22419792.479983766 17036699.7030662 1.0 0.9229418760393451 0.7013393901618422 24.53395788920267 -6.952397186762565 0.5318744467200391 1.0034486420980604 0.6107403969981967 0.9993762331082507 0.003161824228184775 0.08253717089073691 0.03208715861887271 0.0035178134096473072 0.018329886905521633 1.1158422803775301e-07 6.952397186762565 -0.3927082450998637 EQQK(ub)GVQPLTFG ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQQKGVQPLTFG 12 1 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 10654400.0 2944200.0 4549900.0 3160300.0 True False 2850737.982573601 6366698.797415049 2332522.623032228 1.0 2.2333510958686196 0.8182171203705167 21.442904013506013 -6.676394550147604 1.9151481667483339 1.7828957682389954 0.8238049722022223 0.3074876375793343 0.5231454882115923 0.44659305126919546 3.163835654609306 0.21946545692289127 0.5814170043302962 2.1067133621904992e-07 6.676394550147604 -0.9590907960367732 EQQLGLK(ub)QQIESEVANLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQQLGLKQQIESEVANLK 18 1 Q9UBW8 Q9UBW8 COPS7A COP9 signalosome complex subunit 7a 1 12239600.0 6042100.0 3175500.0 3022000.0 True False 5850296.842778329 4443493.710013732 2230447.541943298 1.0 0.7595330338662781 0.38125373838023063 22.480078397907274 -6.964454398091911 0.36729688484234096 1.029996178423788 0.09767900404540428 0.9999014511487682 0.002528267309717247 0.07814660705898444 0.015515816424081959 0.005007451102918853 0.03217439193788593 1.0852895015154379e-07 6.964454398091911 -0.9323171743783838 down EQQLGLK(ub)QQIESEVANLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQQLGLKQQIESEVANLK 18 1 Q9UBW8 Q9UBW8 COPS7A COP9 signalosome complex subunit 7a 1 9460600.0 6042100.0 2382300.0 1036200.0 True False 5024273.860414679 2369466.0770504726 1252864.6291525206 1.0 0.4716036869962555 0.24936232855927865 22.26048367334155 -11.248258006730781 0.16262523821138833 2.0966996453661992 7.423797773339808e-16 0.9995692510015386 0.006534095944277391 3.6557933956237822 0.0972725282502353 1.6425486049737643 0.18518792222128647 5.646014553419568e-12 11.248258006730781 -2.0966996453661984 EQQLPVNEETLFQK(ub)ATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQQLPVNEETLFQKATK 17 1 Q7Z3K3-5;Q7Z3K3-7;Q7Z3K3-2;Q7Z3K3-3;Q7Z3K3-6;Q7Z3K3 Q7Z3K3-5 POGZ Pogo transposable element with ZNF domain 1 9908700.0 3087700.0 3489800.0 3331200.0 True False 4229306.131955017 3335609.0967746503 2544439.168217542 1.0 0.7886894428313111 0.6016209488815989 22.01198956077831 -6.972562155054471 0.18713223056772152 1.1316353037581066 0.2535798207825633 0.9999960811404378 0.00032210600894533217 0.07547979307303106 0.005949876896756966 0.0067687460828914844 0.020557369573668605 1.0652164018605096e-07 6.972562155054471 -0.8780554829755434 EQQLPVNEETLFQK(ub)ATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQQLPVNEETLFQKATK 17 1 Q7Z3K3-5;Q7Z3K3-7;Q7Z3K3-2;Q7Z3K3-3;Q7Z3K3-6;Q7Z3K3 Q7Z3K3-5 POGZ Pogo transposable element with ZNF domain 1 31813500.0 4378300.0 5780200.0 21655000.0 True False 5667795.659195689 5458526.788795835 17714012.199063636 1.0 0.9630775555466038 3.125379470998327 22.434356315092597 -6.903018709400882 0.9420114196989189 0.9173931414238155 3.366772324044483 0.9880085594675985 0.11068027602203077 0.10921646801579142 0.16516335452286993 0.0875973160671589 0.23156004424158905 1.2502051702343903e-07 6.903018709400882 2.4493791826206675 up EQQQLNWK(ub)QDSNPLYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQQQLNWKQDSNPLYK 16 1 P26010;P26010-2 P26010 ITGB7 Integrin beta-7 1 89205100.0 8690000.0 9771100.0 70744000.0 True False 11392674.154079719 8313289.967449492 63424089.504365794 1.0 0.7297048835959643 5.5670941384427834 23.441603088694723 -6.893675003607579 1.0004109563551526 0.7625138911474606 6.014355981839571 0.9831474325016522 0.28811720088115395 0.11621119415299508 0.20484562519324523 0.21831651657960618 0.5519719568089877 1.277394366116984e-07 6.893675003607579 5.25184209069211 up EQQQLNWK(ub)QDSNPLYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQQQLNWKQDSNPLYK 16 1 P26010;P26010-2 P26010 ITGB7 Integrin beta-7 1 180320800.0 7302800.0 13618000.0 159400000.0 True False 7070976.611350614 19055738.416931838 117648358.10250206 1.0 2.694923129337298 16.63820495653291 22.753478056642987 -6.929579660080269 0.7502319100609345 0.784626719306688 19.470310752688043 0.9964550347014968 0.4171746464297998 0.09285663944254295 0.07875303032832649 0.37912058887368566 1.2645549284603017 1.1760352516767217e-07 6.929579660080269 18.685684033381357 EQQQLNWK(ub)QDSNPLYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQQQLNWKQDSNPLYK 16 1 P26010;P26010-2 P26010 ITGB7 Integrin beta-7 1 1062634000.0 13754000.0 263950000.0 784930000.0 True False 20865823.552088328 216846060.24923712 629788241.4529587 1.0 10.392403621544782 30.182764647692384 24.314638527591 -6.959012140492528 0.4491388633530366 0.35615524704635887 41.00243776547916 0.9997317898770999 0.19919959176928106 0.08005590190337514 0.022449501886776305 0.2641817802794392 1.637201206405272 1.0989751176843785e-07 6.959012140492528 40.6462825184328 EQQQLNWK(ub)QDSNPLYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQQQLNWKQDSNPLYK 16 1 P26010;P26010-2 P26010 ITGB7 Integrin beta-7 1 117290100.0 8690000.0 8877100.0 99723000.0 True False 11902927.8384199 8484880.369355902 76170481.25965369 1.0 0.7128397722423108 6.399306313005862 23.504813150217615 -6.8950118528008275 0.9922887310831134 0.730146042456641 6.939202445412876 0.9839161842969714 0.3317118139476744 0.11516988891532443 0.19885981568646932 0.25288951559352124 0.6429459987774346 1.2734683249398012e-07 6.8950118528008275 6.209056402956235 up EQQQLNWK(ub)QDSNPLYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQQQLNWKQDSNPLYK 16 1 P26010;P26010-2 P26010 ITGB7 Integrin beta-7 1 170411800.0 7302800.0 12859000.0 150250000.0 True False 6072601.768894306 12789726.014688345 181666580.3224918 1.0 2.1061361343009795 29.91577370560386 22.533883332077263 -6.915284916830241 0.8589826483049606 0.27604301544021853 33.947420800666194 0.992767179953859 1.1377393949535186 0.10102681118942837 0.12058402900628482 0.9565343007911898 2.747888426745941 1.2153883892655093e-07 6.915284916830241 33.67137778522598 up EQQQLNWK(ub)QDSNPLYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQQQLNWKQDSNPLYK 16 1 P26010;P26010-2 P26010 ITGB7 Integrin beta-7 1 1052434000.0 13754000.0 202850000.0 835830000.0 True False 17804824.131872516 191561219.18051922 683717516.3400303 1.0 10.758950369950828 38.4006891208829 24.08576484968345 -6.952735580855053 0.5279642056281258 0.5575776552621131 49.852511855881524 0.9993988114034889 0.3883801995615344 0.0824056267778322 0.031558327000862745 0.43460892388423006 2.285234554566741 1.1149731756973775e-07 6.952735580855053 49.29493420061941 EQSELVAQALK(ub)ADLVPYLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQSELVAQALKADLVPYLLK 20 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 31783800.0 16109000.0 6794400.0 8880400.0 True False 24438530.725650057 5581886.235110505 7125185.047582408 1.0 0.22840514831981693 0.29155537734942455 24.542654215385486 -10.383754214048032 5.124026314907337 1.0005147349759806 0.25998026283456777 0.9945680092101756 0.025780973043923246 0.0001516986842086967 1.8244165570565142e-05 0.02497874910985872 0.00832077327065159 4.132813295214028e-11 10.383754214048032 -0.7405344721414129 EQSELVAQALK(ub)ADLVPYLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQSELVAQALKADLVPYLLK 20 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 32252900.0 16109000.0 6118900.0 10025000.0 True False 20853418.055862617 5778377.836054607 8200552.865186484 1.0 0.2770949980753925 0.393247420793016 24.313780537477935 -9.944157346854272 5.74060955820711 1.000000577469961 0.33517120945379597 0.9776195881945285 0.0474190280095807 129993732.50886814 0.001395895757895565 992.1817276370524 0.01623279455959553 1.1372151929705366e-10 9.944157346854272 -0.664829368016165 EQSGTIYLQHADEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQSGTIYLQHADEER 15 0 P37198;M0QXN5 P37198 NUP62 Nuclear pore glycoprotein p62 0 11334900.0 2177100.0 3665200.0 5492600.0 False True 2854199.1830663937 3118366.4468377023 4924278.440739564 1.0 1.0925538992998736 1.7252749807913514 21.444654587527836 -6.933140548984015 0.7205453599310175 0.9914094573461082 1.8662078692535975 0.9971203374783548 0.0172956996321915 0.09103943859620943 0.06992923289603252 0.016062662221723686 0.0562943079458611 1.1664320682327674e-07 6.933140548984015 0.8747984119074893 EQSGTIYLQHADEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQSGTIYLQHADEER 15 0 P37198;M0QXN5 P37198 NUP62 Nuclear pore glycoprotein p62 0 9295200.0 2177100.0 2744700.0 4373400.0 False True 2982032.7039153012 2623430.0784908542 3340492.9930003057 1.0 0.8797455759108159 1.1202066927751526 21.507864649050727 -6.770699923439112 1.571512012670753 0.9310892245791469 1.121604130877104 0.7333570678690661 0.050691398592937406 0.26528165378654023 1.2930213473974401 0.02542261052357019 0.06048406570763987 1.6955089107710327e-07 6.770699923439112 0.1905149062979572 EQSILELGSLLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQSILELGSLLAK 13 0 O00231;O00231-2;J3QRY4 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 16323000.0 2428200.0 6342200.0 7552600.0 False True 3183393.714722252 5395968.481701973 6771129.401654877 1.0 1.6950364815848 2.1270160113530445 21.602134166496178 -8.812842188117973 0.13692251220381818 1.5618288358353396e-11 2.9960825841907055 0.9999008045881363 0.004623894865284016 0.3374980535121772 0.040842013540531824 0.4796207660442041 0.34575107425597223 1.5387136692494884e-09 8.812842188117973 2.9960825841750873 EQSILELGSLLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQSILELGSLLAK 13 0 O00231;O00231-2;J3QRY4 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 14167500.0 5263100.0 3573900.0 5330500.0 False True 5096025.771375289 5000976.907642292 3934282.1384277763 1.0 0.9813484334661545 0.7720294823717134 22.280941142864485 -6.924382672793889 0.7915378081282918 1.0039306181910483 0.7346196584378579 0.995314384751753 0.007074534153254238 0.09566119052585786 0.09274924291666042 0.006241480446681515 0.019557221002549273 1.190192823315865e-07 6.924382672793889 -0.2693109597531904 EQSILELGSLLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQSILELGSLLAK 13 0 O00231;O00231-2;J3QRY4 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 23640400.0 2428200.0 11329000.0 9883200.0 False True 3325971.159637652 10828447.320006879 7548991.710893265 1.0 3.2557249597998874 2.269710514181275 21.66534422801907 -10.111598768097844 5.084891452921699 0.999963460800603 2.762717736338041 0.8099313537305319 0.4025387119294518 0.0002443751780541317 4.269584488097232e-05 0.3897681164542824 0.12991881060561158 7.733947718262045e-11 10.111598768097844 1.762754275537438 EQSILELGSLLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQSILELGSLLAK 13 0 O00231;O00231-2;J3QRY4 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 9510300.0 5263100.0 1847000.0 2400200.0 False True 4376500.844863295 1837049.844399203 2902070.722729088 1.0 0.41975311087974565 0.6631029732657889 22.06134641829876 -10.319200243418141 5.769614161451673 1.0000541321874514 0.5414280420727728 0.8256226457684723 0.09934716530372628 6.918465214598029e-05 8.163789310194993e-06 0.09620378333195755 0.03206415972618613 4.7951230531895143e-11 10.319200243418141 -0.4586260901146786 EQSK(ub)QAVEMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQSKQAVEMK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 38389800.0 13932700.0 16419600.0 8037500.0 True False 18265904.62445873 13969859.6830995 7205856.601144117 1.0 0.764805246184924 0.3944976583035042 24.122649869589665 -6.9644394222190265 0.3675460660327761 1.029281047891113 0.11718153690448964 0.9999011191327728 0.0024783900462337946 0.07815170168232113 0.015533814098183371 0.004899911522043003 0.03149202945182739 1.0853269264391454e-07 6.9644394222190265 -0.9120995109866233 down EQSK(ub)QAVEMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQSKQAVEMK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 36799800.0 15048800.0 14724200.0 7026800.0 True False 14571084.081296647 20603649.845688645 5186270.280518582 1.0 1.4140093990765836 0.35592892413376753 23.796604881389445 -6.800585602204213 1.4535834313884808 1.2282590751730615 0.34112211595455255 0.8338473224752735 0.17745657544910257 0.21992660653563834 0.9173492934944745 0.09603994746184308 0.22326801425725584 1.582757564377384e-07 6.800585602204213 -0.887136959218509 down EQSK(ub)QAVEMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQSKQAVEMK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 27828600.0 7883800.0 12294200.0 7650600.0 True False 11960300.982983435 10100203.954976961 6138455.556622904 1.0 0.8444774064922836 0.5132358763676947 23.51175035986744 -6.95879599211737 0.4520832763873278 1.0104573082790853 0.3340787953784913 0.9997229022333971 0.0033790321639551937 0.08013406141483584 0.022741938264020163 0.004441343652887605 0.02739089485354392 1.0995222137631622e-07 6.95879599211737 -0.676378512900594 EQSK(ub)QAVEMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQSKQAVEMK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 28104540.0 13932700.0 10760100.0 3411740.0 True False 19083995.707060162 10284683.203107592 2605957.2789909127 1.0 0.5389166588055118 0.13655197365333893 24.185859931112557 -7.899839343040546 0.3930626538501376 1.058496664485581 4.800936422923071e-18 0.9978644004277057 0.016302527733079893 0.10593868238577928 0.0775210106879818 0.040413695888439384 0.08128530691580829 1.2593912075885612e-08 7.899839343040546 -1.058496664485581 down EQSK(ub)QAVEMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQSKQAVEMK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 31252500.0 15048800.0 12830700.0 3373000.0 True False 12513743.974877672 12761578.472405441 4078278.7050100835 1.0 1.0198049838661647 0.32590395913465625 23.57701015682372 -6.900329375778623 0.9591740102885155 1.0285897086793883 0.25257580124769735 0.9867297327323847 0.03715568208620324 0.11116355607019522 0.17605165708409024 0.029034759842360213 0.07566986452606166 1.2579709848958532e-07 6.900329375778623 -0.776013907431691 down EQSK(ub)QAVEMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQSKQAVEMK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 19804600.0 7883800.0 8279900.0 3640900.0 True False 10205734.512931272 7819116.286382941 2978293.5587887694 1.0 0.7661492934659093 0.29182549820545445 23.28287668195989 -6.959768965947794 0.4386788790972701 1.0171953131625 0.022326827012800546 0.9997615311207527 0.004549565307753449 0.07978377231137995 0.021437148637934413 0.006243568131224878 0.03931066477933902 1.0970616509287162e-07 6.959768965947794 -0.9948684861496995 down EQSTCNFQAIVISLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQSTCNFQAIVISLK 15 0 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 0 4951000.0 1163000.0 1983200.0 1804800.0 False True 1524704.2625080205 1687314.2904530524 1618056.608864063 1.0 1.1066502087936392 1.0612265267773864 20.540098008466178 -10.270923831367414 5.811013495346319 0.9999951388095504 1.0839383677854744 0.8199162827450477 0.018544140529711834 1.1694290892680012e-06 1.4670898320333874e-07 0.017956327901725307 0.005985095620108295 5.3589063632141255e-11 10.270923831367414 0.08394322897592399 EQSTCNFQAIVISLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQSTCNFQAIVISLK 15 0 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 0 1817500.0 0.0 0.0 1817500.0 False True 0.0 0.0 1341442.2261687424 0.0 EQSTCNFQAIVISLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQSTCNFQAIVISLK 15 0 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 0 9604400.0 1163000.0 2702600.0 5738800.0 False True 1592992.5288932482 2583190.1956969355 4383413.634296002 1.0 1.6215959264364157 2.7516849921081765 20.60330806998907 -6.961866523361006 0.4082773015980123 0.9432742221709539 3.471828022840322 0.9998332829477584 0.009362367356421127 0.07904097852288436 0.018716453075311945 0.014545917336030134 0.0944072604442813 1.0917758327148925e-07 6.961866523361006 2.528553800669368 EQTGLEAYALGLDTK(ub)NYFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQTGLEAYALGLDTKNYFK 19 1 P48449;P48449-3;C9J315 P48449 LSS Lanosterol synthase 1 102185000.0 14448000.0 29183000.0 58554000.0 True False 21918672.290284444 23975065.64218028 46980776.23487014 1.0 1.0938192480211195 2.143413415405394 24.38565707481674 -6.92442840595867 0.7911699505331614 0.9803260381051502 2.3312134217064164 0.9953258167516423 0.035436087359876654 0.09563491418725178 0.09261516627131196 0.031271652516563504 0.09803914300592909 1.1900674972503743e-07 6.92442840595867 1.3508873836012663 up EQTGLEAYALGLDTK(ub)NYFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQTGLEAYALGLDTKNYFK 19 1 P48449;P48449-3;C9J315 P48449 LSS Lanosterol synthase 1 17554600.0 1121200.0 3044400.0 13389000.0 True False 1535737.9392907238 2909888.341515484 10226793.955110693 1.0 1.8947818290270328 6.659205124432824 20.550500622660984 -6.93841195560319 0.6741746645440042 0.9447676753234661 7.886142468972233 0.9979484255041455 0.1125056581311492 0.08849862130272376 0.05796503612378027 0.10824051550225791 0.41301584832166177 1.1523596536916793e-07 6.93841195560319 6.941374793648767 EQTGLEAYALGLDTK(ub)NYFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQTGLEAYALGLDTKNYFK 19 1 P48449;P48449-3;C9J315 P48449 LSS Lanosterol synthase 1 93610000.0 14448000.0 21687000.0 57475000.0 True False 18703220.812657714 20480099.38559488 47015139.74330096 1.0 1.095003881456323 2.513745638477555 24.15678339690919 -6.920480261411773 0.8211668209496054 0.9692352312310122 2.7450696471703115 0.9943131123401246 0.0522059353707833 0.09788986555899903 0.10415911759434113 0.045095529681684315 0.13570694426432192 1.2009356540343944e-07 6.920480261411773 1.7758344159392994 up EQVANSAFVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQVANSAFVER 11 0 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 198057000.0 23799000.0 104630000.0 69628000.0 False True 31200719.469843864 89019611.84454557 62423562.47893791 1.0 2.8531268944161643 2.0007090714453417 24.895075961363425 -10.16895153406281 7.645542627587712 0.9999993682434843 2.426917982930753 0.7888608811676756 0.34799811898876615 3.747066597623642e-06 4.0781793582120404e-07 0.33694788042403057 0.11231590994624982 6.777171345521748e-11 10.16895153406281 1.4269186146872683 EQVANSAFVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQVANSAFVER 11 0 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 163757000.0 46275000.0 13142000.0 104340000.0 False True 44806025.45465436 18389669.134624638 77010223.86709586 1.0 0.41042848474109317 1.7187470454176648 25.41718942124929 -6.784180951604123 1.5194084984840357 0.6679845766410254 1.730535235307609 0.7819647257185558 0.24980764582407783 0.24412928963037647 1.113388250913282 0.1294562255941107 0.30443476308182105 1.643686727817398e-07 6.784180951604123 1.0625506586665838 EQVANSAFVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQVANSAFVER 11 0 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 474683600.0 9690900.0 455580000.0 9412700.0 False True 14701803.799689773 374278189.5372132 7552275.719267035 1.0 25.457977445264977 0.5136972185294976 23.809489837859395 -11.851845329478579 4.5258664181079174e-10 8.696227770235417 14.878277408936174 0.0 11.97701391955953 732263219.0219464 0.7720995356753407 589000223.9978245 589000228.2295679 1.406548365939324e-12 11.851845329478579 6.182049638700757 EQVANSAFVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQVANSAFVER 11 0 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 139891000.0 23799000.0 60928000.0 55164000.0 False True 32598133.443792306 58235999.498047344 42135399.33824228 1.0 1.7864826401321847 1.2925709200772095 24.958286022886316 -10.208666334635948 4.840858833440326 0.9999203371229288 1.5395267801059522 0.6140463957097432 0.20163861535698852 0.0001733965512199783 2.8344358692213994e-05 0.19526442095002278 0.06507858326852423 6.184914001928117e-11 10.208666334635948 0.5396064429830234 EQVANSAFVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQVANSAFVER 11 0 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 68178600.0 46275000.0 13655000.0 8248600.0 False True 38479712.83009041 13581437.804694705 9973344.122782735 1.0 0.3529506019097491 0.25918447382444515 25.197594696683566 -13.999999999999998 0.2720513155080924 6.049626892288878 0.22867364885801056 0.9995877553187804 0.006687159413752412 14.984575262577987 0.1651313694565695 41.90041882150531 0.03854786661186226 1.0000000000000041e-14 13.999999999999998 -5.820953243430868 EQVANSAFVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EQVANSAFVER 11 0 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 63729900.0 9690900.0 31455000.0 22584000.0 False True 12545061.086197738 29704501.598832738 18473943.731408603 1.0 2.367824388795848 1.472606917134418 23.580616159951845 -10.103349011173927 4.882221699802852 0.9999684044239057 1.9202156529664771 0.5848619740557754 0.3654710024415578 48175014.32329609 99694171.420371 12949.533646357138 0.12511044102013857 7.882264222597819e-11 10.103349011173927 0.9202472485425714 EQVAQLK(ub)QK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQVAQLKQK 9 1 U3KPR5;P05412;P17535;P17275 U3KPR5 JUND;JUN;JUNB Transcription factor AP-1;Transcription factor jun-D;Transcription factor jun-B 1 3562600.0 1233500.0 1255600.0 1073500.0 True False 1194343.2176837644 1756967.627867499 792318.1456903148 1.0 1.4710743125203605 0.663392343138087 20.187786051904116 -6.748585532864619 1.6549157588238907 1.2774612713564186 0.6619414730877214 0.6429504323602786 0.19793657022860822 0.3025078267668788 1.62958789463102 0.09449787439875847 0.22977177625466577 1.784080585155577e-07 6.748585532864619 -0.6155197982686972 EQVAQLK(ub)QK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQVAQLKQK 9 1 U3KPR5;P05412;P17535;P17275 U3KPR5 JUND;JUN;JUNB Transcription factor AP-1;Transcription factor jun-D;Transcription factor jun-B 1 1895600.0 619720.0 819580.0 456300.0 True False 848847.2313032885 783368.245611372 348531.3377934878 1.0 0.9228612837773148 0.41059371455846744 19.695145406928027 -6.933727173300899 0.7155360964906649 1.0068165856279079 0.29469649317508095 0.9972214198296186 0.013787921638354466 0.09074818958326683 0.06853417823943152 0.012852563913724203 0.045438922058697706 1.1648575709261221e-07 6.933727173300899 -0.7121200924528269 down EQVAQLK(ub)QK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQVAQLKQK 9 1 U3KPR5;P05412;P17535;P17275 U3KPR5 JUND;JUN;JUNB Transcription factor AP-1;Transcription factor jun-D;Transcription factor jun-B 1 3419930.0 1233500.0 1703400.0 483030.0 True False 1025709.9033153227 1694223.4461015747 584029.3397216188 1.0 1.651756935002253 0.5693903684013443 19.968191327338392 -6.74365489640671 1.673230927126961 1.386146388697189 0.568229115959309 0.6212399996489358 0.2738303875127408 0.311259121312662 1.712378717842852 0.12939255134202882 0.31626314392599 1.8044510429464478e-07 6.74365489640671 -0.81791727273788 EQVIAALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQVIAALR 8 0 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 0 8773100.0 1956500.0 3641600.0 3175000.0 False True 2564990.4467729516 3098287.4748456185 2846481.456750553 1.0 1.2079138457391196 1.1097434925466287 21.290522021893754 -10.104529080930536 4.077452406015096 0.9999657343241459 1.1588286691075869 0.7772869893287125 0.04007787904110601 18606784.760471098 17262194.320121814 7318.200749432685 0.01466700059110085 7.860875519278852e-11 10.104529080930536 0.15886293478344093 EQVIAALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQVIAALR 8 0 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 0 7301300.0 1581900.0 1275000.0 4444400.0 False True 1531683.4503882802 1784114.1490371614 3280278.3108579745 1.0 1.164806049569113 2.1416163437859352 20.546686738817616 -6.936094811395361 0.6949481816548717 0.9879518215009604 2.377288326476768 0.997606300674067 0.024650135365916308 0.08959423433902619 0.0630672746668852 0.023336696065390357 0.0856178305760806 1.1585244095691527e-07 6.936094811395361 1.3893365049758075 up EQVIAALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQVIAALR 8 0 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 0 9093400.0 1956500.0 3559200.0 3577700.0 False True 2679870.9224244547 3401942.775299534 2732720.9450443997 1.0 1.2694427730951414 1.0197211075271237 21.353732083416645 -10.650576227385862 2.882640958820474 0.9857989488428585 1.144581940055926 0.30888885131882904 0.1019484449506273 479886701.9445435 409686856.49658984 49970408.066185445 0.037309303971785626 2.2357527448652756e-11 10.650576227385862 0.1587829912130676 EQVIAALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQVIAALR 8 0 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 0 3266570.0 1581900.0 972770.0 711900.0 False True 1315419.940052295 967529.4949302725 860754.998546303 1.0 0.73552898619722 0.6543575723141944 20.327092014251892 -13.999999995147025 0.1654377229433612 2.3185615492254312 0.5791632050752237 0.9995231313154836 0.0032226129565543875 12.050414360437895 0.12869923265450162 5.097795333996152 0.06903161722446038 1.0000000111743878e-14 13.999999995147025 -1.7393983441502074 EQVK(ub)IAENVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQVKIAENVK 10 1 B8ZZD4;Q86VP1-3;Q86VP1-4;Q86VP1-2;Q86VP1;H7C3L5 B8ZZD4 TAX1BP1 Tax1-binding protein 1 1 4128890.0 1365100.0 1887900.0 875890.0 True False 1789659.3196472046 1606232.6789765628 785261.3049301557 1.0 0.8975075095818792 0.43877697632695495 20.77125355087325 -6.942303050098907 0.6377797757211755 1.0050150062316854 0.3062146865259488 0.9984502433559839 0.00960630181434883 0.08673155021901524 0.04994207382132508 0.009523056642111347 0.03909899298509256 1.142081114024003e-07 6.942303050098907 -0.6988003197057366 down EQVK(ub)IAENVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EQVKIAENVK 10 1 B8ZZD4;Q86VP1-3;Q86VP1-4;Q86VP1-2;Q86VP1;H7C3L5 B8ZZD4 TAX1BP1 Tax1-binding protein 1 1 7008700.0 1788900.0 2893300.0 2326500.0 True False 1732112.348694354 4048609.778360173 1717119.8564960544 1.0 2.337382896330003 0.9913443881341757 20.724101078861956 -6.647679307706348 2.0171915513030636 1.8694251574772014 0.9970330190526994 0.1846134419588975 0.5711381608072328 0.5141934024395227 4.007866258995297 0.22985781156239146 0.6324051766841535 2.2507159689673698e-07 6.647679307706348 -0.872392138424502 EQVK(ub)IAENVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EQVKIAENVK 10 1 B8ZZD4;Q86VP1-3;Q86VP1-4;Q86VP1-2;Q86VP1;H7C3L5 B8ZZD4 TAX1BP1 Tax1-binding protein 1 1 11609300.0 3573900.0 5471400.0 2564000.0 True False 5421867.587088015 4494985.921756686 2057224.276158876 1.0 0.8290475282836739 0.37943093281327683 22.370358449415303 -6.954366246581239 0.5086625998351859 1.0083666847575006 0.18043153530672001 0.9995008501041506 0.005847302529495704 0.08177852449356199 0.02906297625304725 0.006750599696141696 0.03710469883928542 1.1107945836512082e-07 6.954366246581239 -0.8279351494507805 down EQVK(ub)IAENVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQVKIAENVK 10 1 B8ZZD4;Q86VP1-3;Q86VP1-4;Q86VP1-2;Q86VP1;H7C3L5 B8ZZD4 TAX1BP1 Tax1-binding protein 1 1 3861100.0 1365100.0 1085600.0 1410400.0 True False 1869814.3604403897 1037634.6024008698 1077292.5680997905 1.0 0.5549399043852032 0.5761494782006381 20.834463612396142 -10.040233169071874 4.974828862079656 1.000007299101064 0.5655446912893094 0.9982157342625347 0.008658772264180582 7.009889192312865e-07 1.3525859049462537e-07 0.008383960924326847 0.0027946067296852495 9.115213197918996e-11 10.040233169071874 -0.4344626078117546 EQVK(ub)IAENVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EQVKIAENVK 10 1 B8ZZD4;Q86VP1-3;Q86VP1-4;Q86VP1-2;Q86VP1;H7C3L5 B8ZZD4 TAX1BP1 Tax1-binding protein 1 1 6152050.0 1788900.0 3528200.0 834950.0 True False 1487549.6117071586 3509192.886307136 1009534.1846273863 1.0 2.3590425883543316 0.678655808641443 20.504506354296232 -6.691510628263667 1.860992374956592 1.8508146596461574 0.6843421489953836 0.37755819306940963 0.5746024134580461 0.41341385946103204 2.777104719534934 0.24689477606040866 0.6417228462697716 2.0346484023458705e-07 6.691510628263667 -1.1664725106507738 EQWWLSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EQWWLSLR 8 0 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 0 7656200.0 1737500.0 2867200.0 3051500.0 False True 2277879.3259739373 2439424.9362580646 2735760.052054907 1.0 1.0709193013177098 1.2010118450349414 21.119259889491193 -6.961699690968472 0.4107800266597424 0.9936458000148911 1.2831193329804549 0.9998281262103995 0.0010912603747879372 0.07909948720105271 0.018928607503794808 0.0016755524316438913 0.010859024059075332 1.0921953143597129e-07 6.961699690968472 0.2894735329655638 EQWWLSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EQWWLSLR 8 0 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 0 7204800.0 1737500.0 1944400.0 3522900.0 False True 2379900.704171988 1858489.9787290462 2690863.576402973 1.0 0.7809107226495189 1.1306621203505944 21.182469951014085 -6.737349948766602 1.6964117907132308 0.8692441873974922 1.1307504496283645 0.5929826853268301 0.09205948094982593 0.32263160177966144 1.8220138840024507 0.04294920923174562 0.10570111577903206 1.830838562266025e-07 6.737349948766602 0.26150626223087226 ERDAVNQNTK(ub)LLQSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ERDAVNQNTKLLQSAK 16 2 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 10643500.0 4505600.0 3994500.0 2143400.0 True False 4362572.194240754 5589524.681042312 1581979.2393783117 1.0 1.2812451994310416 0.3626253432474448 22.056747575353928 -6.824522033654266 1.3521312742321814 1.1509356694703234 0.3405463437597871 0.8944884789782834 0.12483176757489643 0.1876649830766673 0.6728920005066125 0.07252417555931043 0.16699502484441725 1.4978832569629126e-07 6.824522033654266 -0.8103893257105363 down ERDAVNQNTK(ub)LLQSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ERDAVNQNTKLLQSAK 16 2 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 7047200.0 2749100.0 3235800.0 1062300.0 True False 3765516.5616340777 3092831.6566403257 811406.6187552521 1.0 0.8213565406012091 0.2154834816084663 21.844416359796035 -6.9490281660380395 0.5734626820715156 1.007424994266015 1.442396193139342e-22 0.9990926355855041 0.010113172118727972 0.0839545373766824 0.038216142142634434 0.010674940558101082 0.05047601047609985 1.124532040414555e-07 6.9490281660380395 -1.007424994266015 down ERDAVNQNTK(ub)LLQSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ERDAVNQNTKLLQSAK 16 2 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 12706730.0 4505600.0 7318400.0 882730.0 True False 3746606.031923404 7278974.326611344 1067304.7617176268 1.0 1.9428181838682728 0.28487242923956485 21.837152850788204 -6.752439652523709 1.6407222399631045 1.5527551386455591 0.2809363327037061 0.6594363582743981 0.396236716690941 0.29581068918688 1.5674472808324553 0.19071347636815456 0.4618381035155484 1.7683179176319698e-07 6.752439652523709 -1.271818805941853 EREAELGAK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EREAELGAKAK 11 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 2552970.0 1027500.0 933760.0 591710.0 True False 1347062.4503241556 794446.647767972 530485.5252831096 1.0 0.5897622991248825 0.3938091549916295 20.361385305562006 -13.14926981741453 0.10637294739212336 2.692154291972014 3.0626127922226375e-16 0.9997901501178722 0.0036588871586221926 8.933416479361174 0.08961832564573775 3.5060018295966344 0.3277549066992421 7.091370601366602e-14 13.14926981741453 -2.6921542919720136 EREAELGAK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EREAELGAKAK 11 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 4146300.0 1011500.0 1388100.0 1746700.0 True False 1534519.4505552815 1140382.7097251976 1401463.979394195 1.0 0.7431529846770848 0.9132917662836146 20.549355501894166 -10.090367313593802 6.206286588824296 1.00000038860729 0.828222375733293 0.5761173322856108 0.06945886673247778 3.7348574319991196e-07 5.473980955736306e-08 0.06725341085056513 0.022417752841776138 8.121433384820474e-11 10.090367313593802 -0.17177801287399685 EREAELGAK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EREAELGAKAK 11 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 2680500.0 1159800.0 1169800.0 350900.0 True False 964425.087851731 1163498.0552128796 424271.5676217137 1.0 1.2064162057465615 0.43992174505412746 19.879309655083297 -6.835003716435572 1.3052753602634115 1.1099788427140247 0.4170877919038357 0.9155296925189973 0.09411803536045207 0.17472337827774193 0.5803772795894482 0.05658032910932717 0.13023541130852676 1.4621646620619287e-07 6.835003716435572 -0.692891050810189 down EREAELGAK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EREAELGAKAK 11 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 2526230.0 1011500.0 1050200.0 464530.0 True False 1309406.6896458522 991755.4468000048 379990.3064803062 1.0 0.757408263332028 0.29020037050756176 20.320481823986615 -6.960776679903008 0.42434916732120515 1.0197096846488345 0.010148444162854674 0.9997979209011534 0.004187458353920252 0.07942487575184319 0.020115039985400773 0.006062383534276124 0.038846343213699994 1.0945190380871442e-07 6.960776679903008 -1.0095612404859797 down EREDGKEDEGGNEEEAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EREDGKEDEGGNEEEAGK 18 2 P82970 P82970 HMGN5 High mobility group nucleosome-binding domain-containing protein 5 0 3220340.0 1063700.0 510940.0 1645700.0 False True 1029933.4257399437 714961.0065168999 1214641.800058268 1.0 0.6941817681111228 1.1793401104402672 19.97411965483077 -6.736331037535442 1.7001028506951554 0.8172698745899707 1.179404190711913 0.5883622888962445 0.12850788918186845 0.32450013193942606 1.8401270615110037 0.05983326635779181 0.14742243903348767 1.835138989905997e-07 6.736331037535442 0.36213431612194236 EREEQETTSSK(ub)ITELQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EREEQETTSSKITELQLK 18 2 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 49171000.0 16683000.0 18107000.0 14381000.0 True False 21871574.558401816 15405506.180533199 12892992.072292846 1.0 0.7043620082951586 0.5894862319064309 24.382553749518813 -13.999999999992081 0.1307757253533208 2.4051166238941386 0.4301843350860335 0.9996421180754586 0.0032713031585760626 11.935610865664193 0.11253410769428072 4.307888700872005 0.14171407883673126 1.0000000000182342e-14 13.999999999992081 -1.9749322888081051 EREEQETTSSK(ub)ITELQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EREEQETTSSKITELQLK 18 2 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 53770000.0 24445000.0 15126000.0 14199000.0 True False 23669006.8555165 21165890.68104797 10479855.939130675 1.0 0.8942449850241547 0.4427670329855074 24.49649583649949 -6.943381694195384 0.627316183681181 1.0049258604963967 0.3078657209348415 0.9985741140914164 0.009124682369684806 0.08625723755010967 0.04783492913315864 0.009128869228611435 0.03831680707447025 1.1392480812476368e-07 6.943381694195384 -0.6970601395615552 down EREEQETTSSK(ub)ITELQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EREEQETTSSKITELQLK 18 2 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 129059000.0 38059000.0 45541000.0 45459000.0 True False 57738285.48559916 37413852.73654295 36474008.72461252 1.0 0.647990365870399 0.6317127087833204 25.78302493219159 EREEQETTSSK(ub)ITELQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EREEQETTSSKITELQLK 18 2 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 48905000.0 16683000.0 19666000.0 12556000.0 True False 22851155.941123016 18797091.09323464 9590531.398937158 1.0 0.822588193860571 0.4196956785751922 24.445763811041704 -6.957486807015249 0.4695203619537284 1.0106912571358508 0.21508950455450354 0.9996653110199749 0.004441834999584191 0.08061150203635387 0.024543942796135185 0.005565636322640719 0.03325405626280861 1.1028417354338706e-07 6.957486807015249 -0.7956017525813472 down EREEQETTSSK(ub)ITELQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EREEQETTSSKITELQLK 18 2 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 53925000.0 24445000.0 18329000.0 11151000.0 True False 20327100.597116373 18230258.038978357 13482622.54360137 1.0 0.8968449755969882 0.6632831120791536 24.276901111933768 -6.957548283227775 0.46871383936132394 1.006246747021536 0.544327217370345 0.999668168967901 0.0025659065729981066 0.08058889092242377 0.024457881247997106 0.0032216236100008097 0.019278966552343183 1.1026856345912916e-07 6.957548283227775 -0.461919529651191 EREEQETTSSK(ub)ITELQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EREEQETTSSKITELQLK 18 2 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 162670000.0 38059000.0 42011000.0 82600000.0 True False 49268125.755048506 39673050.919362985 67567647.54757132 1.0 0.8052478212102007 1.3714271958203659 25.55415125428404 -6.813847770363175 1.398335075700566 0.8943330101587011 1.3822243571296333 0.869621025251724 0.08480439947934686 0.20160540340260394 0.7761892285384714 0.04767709690696001 0.11010547928910155 1.5351549936281155e-07 6.813847770363175 0.48789134697093217 ERHPGSFDVVHVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ERHPGSFDVVHVK 13 1 P62701;C9JEH7;P22090 P62701 RPS4X;RPS4Y1 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1 0 8197900.0 2520600.0 1133500.0 4543800.0 False True 2440584.932706685 1586112.461124412 3353642.4689218863 1.0 0.6498902946865954 1.3741142231844365 21.218795527924303 -6.7752424613318665 1.554246560267984 0.8005325472898666 1.3790331524864885 0.7502361854651265 0.14778879516823978 0.2580455056960219 1.2308321703742922 0.07491704933666231 0.1775004131494798 1.6778670238200294e-07 6.7752424613318665 0.5785006051966219 ERPAYAVHGNMLHYVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ERPAYAVHGNMLHYVK 16 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 18987600.0 6328100.0 6433200.0 6226300.0 False True 8296200.381407579 5473391.636417196 5582062.202886922 1.0 0.6597467979056396 0.6728456336947636 22.984019309879812 -10.014216120098665 6.012213485570789 1.0000003950190104 0.6662962158071327 0.9988457408551291 0.005347577318082513 2.831419670522571e-08 4.645559610887094e-09 0.005177775646054519 0.0017259231579420137 9.67796127262676e-11 10.014216120098665 -0.33370417921187767 ERPAYAVHGNMLHYVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ERPAYAVHGNMLHYVK 16 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 8853870.0 2969000.0 983370.0 4901500.0 False True 2874750.7201484316 1376034.7692068042 3617650.108151913 1.0 0.47866229219894085 1.2584221938955193 21.455005429590646 -6.726530479506559 1.735904131803345 0.6850503730640254 1.2576685799090659 0.5430642644106041 0.21922479937968284 0.34279816924754863 2.0220454661494474 0.1001460901867184 0.2494855958624166 1.8770226811894822e-07 6.726530479506559 0.5726182068450405 ERPAYAVHGNMLHYVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ERPAYAVHGNMLHYVK 16 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 15458400.0 4649700.0 7136400.0 3672300.0 False True 7053934.838602958 5862853.663052306 2946468.2953737313 1.0 0.8311465582255722 0.41770562994841665 22.74999681811661 -6.95590619044199 0.489734942295201 1.0090696128727323 0.22225876067711164 0.9995869414401743 0.004971435451873102 0.08119728813514239 0.02679171749660921 0.005949284196138797 0.03409936901141816 1.106862845501837e-07 6.95590619044199 -0.7868108521956207 down ERPAYAVHGNMLHYVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ERPAYAVHGNMLHYVK 16 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 16563000.0 6328100.0 5000400.0 5234500.0 False True 8667769.580472378 4779465.793888458 3998218.9079114897 1.0 0.5514066507554745 0.4612742494815597 23.047229371402704 -13.999999999999943 0.22560766270066648 3.7754815175963103 0.4155785737450313 0.9995041200482863 0.005246522903505728 13.158296908143758 0.15042669710995693 16.31966845758614 0.048099531943930345 1.000000000000131e-14 13.999999999999943 -3.359902943851279 ERPAYAVHGNMLHYVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ERPAYAVHGNMLHYVK 16 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 6870900.0 2969000.0 2146900.0 1755000.0 False True 2468855.049001368 2135334.2235737126 2121962.3857968296 1.0 0.8649087051252514 0.8594924949746021 21.235410705024922 ERPAYAVHGNMLHYVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ERPAYAVHGNMLHYVK 16 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 16386500.0 4649700.0 6406400.0 5330400.0 False True 6019128.309289489 6049878.208321808 4360321.894522688 1.0 1.0051086963846345 0.7244108566008274 22.52112314020906 -6.902755395291508 0.943676951232875 1.0108045674895332 0.6932402799130062 0.9878881853576076 0.01443185487667555 0.10940564397597423 0.16619888386532639 0.011407716756786703 0.03011329691432685 1.2509634033948709e-07 6.902755395291508 -0.317564287576527 ERPPNPIEFLASYLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ERPPNPIEFLASYLLK 16 1 Q9C005 Q9C005 DPY30 Protein dpy-30 homolog 0 148609000.0 62403000.0 0.0 86206000.0 False True 51890859.42163436 0.0 104231276.02849072 1.0 0.0 2.0086635139643607 25.62897709434648 -6.771325500613316 1.5692740544880714 0.4274076473368714 2.02056942787785 0.7356703187100214 0.42160512200890443 0.2642749085489218 1.2845591160086813 0.21173929630810995 0.5034387765340415 1.6930683821329e-07 6.771325500613316 1.5931617805409788 ERPQIGGTIK(ub)QPPSNPPPRPPAEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ERPQIGGTIKQPPSNPPPRPPAEAR 25 3 P13498 P13498 CYBA Cytochrome b-245 light chain 1 16504100.0 1123200.0 1321600.0 14059300.0 True False 1472526.0770842715 1124422.4315564525 12604578.50232854 1.0 0.763601031625128 8.559833811083802 20.489861752410157 -6.899906618905389 0.9618514881519244 0.6750302303046614 9.37664834948632 0.9865199888120696 0.4203811086534693 0.11147426552610383 0.1778049415742322 0.32784890082320967 0.8526141251080878 1.2591961324169874e-07 6.899906618905389 8.701618119181658 up ERPTPSLNNNCTTSEDSLVLYNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ERPTPSLNNNCTTSEDSLVLYNR 23 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 21963000.0 2365100.0 9965200.0 9632700.0 False True 3100669.0036609815 8478431.004045373 8636000.60738302 1.0 2.7343876415169857 2.785205578920689 21.56414809583455 -10.620427756814836 0.6579274286234192 2.7656772301021177e-09 2.7774532222275456 0.9999146915358128 0.007664572273275786 2.1137644760815135 0.3285720507582509 3.492918225058963 0.008249718177644342 2.3964713602105508e-11 10.620427756814836 2.7774532194618686 ERPTPSLNNNCTTSEDSLVLYNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ERPTPSLNNNCTTSEDSLVLYNR 23 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 22432100.0 2365100.0 9207000.0 10860000.0 False True 3239541.384424268 8800204.296522489 8295091.66872075 1.0 2.7164969519555817 2.560575922444947 21.627358157357442 -10.274009276203103 5.055498793253768 0.9996498885573323 2.6385364372008517 0.9932544253005046 0.06365449374721621 0.00025124136138930577 3.6079263241692616e-05 0.06164532271465194 0.02054439951588018 5.3209689395644026e-11 10.274009276203103 1.6388865486435193 ERYDNLEMEYLQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ERYDNLEMEYLQKR 14 2 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 27659900.0 4817400.0 9608500.0 13234000.0 True False 7308347.99911519 7893788.103446844 10618294.099331748 1.0 1.0801056688053898 1.4528993557254373 22.801113901243106 -6.941418263710707 0.6462384529824732 0.9958964501091745 1.5577666328713882 0.9983437826603576 0.008031329193240597 0.08712560369656916 0.05170839797535137 0.00790459761578988 0.03189047276679272 1.1444102430067557e-07 6.941418263710707 0.5618701827622137 ERYDNLEMEYLQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ERYDNLEMEYLQKR 14 2 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 26955100.0 4817400.0 5865700.0 16272000.0 True False 6236219.265150696 5539268.638635295 13310662.964819396 1.0 0.8882414814356983 2.134412277515991 22.572240223335555 -6.8850107036916075 1.051421980434624 0.9248165786922171 2.2316858956092385 0.9775089410195118 0.08442732628772381 0.12328574629760615 0.246230399971612 0.06154778010143936 0.1509307112257715 1.3031346607902027e-07 6.8850107036916075 1.3068693169170214 up ESAEALATK(ub)LNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESAEALATKLNK 12 1 A0MZ66-2;A0MZ66-8;A0MZ66-4;A0MZ66-5;A0MZ66-6;A0MZ66;A0MZ66-3 A0MZ66-2 KIAA1598 Shootin-1 1 3464670.0 1492300.0 1183200.0 789170.0 True False 1240913.5700992756 1176825.866753189 954181.7982901903 1.0 0.9483544181558434 0.7689349373573647 20.242971204267487 -6.948115077282973 0.5791710309496427 1.0021514008434138 0.7062762612647816 0.9990449107076116 0.0030602473416153847 0.08425166298676753 0.03916426867385758 0.003209221890158811 0.014984556938216188 1.1268988163310136e-07 6.948115077282973 -0.2958751395786322 ESAK(ub)VGDQAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESAKVGDQAQR 11 1 P61158 P61158 ACTR3 Actin-related protein 3 1 8312570.0 4256100.0 3319300.0 737170.0 True False 5579788.316131024 2824073.3785300627 660894.7198339545 1.0 0.5061255407065783 0.11844440727676442 22.411778960005712 -8.048751446330275 0.39237664796659627 1.0676405117429846 7.62807599827342e-25 0.9975438797113946 0.017879142141241856 0.09631217146304329 0.08834282949120398 0.05114856167999425 0.08307185960406227 8.938168830589814e-09 8.048751446330275 -1.0676405117429846 down ESAK(ub)VGDQAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESAKVGDQAQR 11 1 P61158 P61158 ACTR3 Actin-related protein 3 1 12037030.0 3100800.0 8149400.0 786830.0 True False 3002366.8012921065 11403497.918559577 580735.6186059711 1.0 3.7981694687177923 0.19342593928098464 21.51766881213171 -6.699496290375735 1.8325596956004029 2.738413105448481 0.204218541980767 0.4152024844986528 1.1812530259072342 0.39658924647413446 2.588943616185707 0.5142979604223943 1.3235138250186316 1.9975778311314003e-07 6.699496290375735 -2.534194563467714 ESAK(ub)VGDQAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESAKVGDQAQR 11 1 P61158 P61158 ACTR3 Actin-related protein 3 1 10411520.0 3100800.0 6124500.0 1186220.0 True False 2578452.5887313737 6091506.102881935 1434253.1175384137 1.0 2.3624658174843627 0.5562456815403698 21.298074087565986 -6.704911169099995 1.8132298543368468 1.8419265929127935 0.5610716573490621 0.4409681237066433 0.5746133580485739 0.385393087811159 2.4666379939661547 0.2524907125425023 0.6454621874351539 1.972826218116961e-07 6.704911169099995 -1.2808549355637315 ESCLEAYTGIVQGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESCLEAYTGIVQGLK 15 0 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 0 14518400.0 2998600.0 5292400.0 6227400.0 False True 3931193.6384837087 4502794.549613621 5583048.385438868 1.0 1.1454013624600754 1.4201916514069992 21.906535997548104 -6.96113739881151 0.41909831510565276 0.9877352309562242 1.5882082108298092 0.9998100782968978 0.0024011257118269833 0.07929732386196227 0.01964857262684288 0.003552659671460046 0.022879937325054403 1.0936103233527492e-07 6.96113739881151 0.600472979873585 ESCLEAYTGIVQGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESCLEAYTGIVQGLK 15 0 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 0 12436500.0 2998600.0 4290300.0 5147600.0 False True 4107263.454118054 4100740.359875144 3931842.898149809 1.0 0.9984118149917143 0.9572901621900188 21.969746059070996 -6.915053095524699 0.8606196718869942 1.0010788896310603 0.9513589286797577 0.9926926478797973 0.001689982167666292 0.10117040227930124 0.121345417133389 0.0014191583073896918 0.004069226149142681 1.2160373225273167e-07 6.915053095524699 -0.0497199609513026 ESDLNGAQIK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESDLNGAQIKLR 12 1 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 17293600.0 11997000.0 0.0 5296600.0 True False 15728183.179113276 0.0 4748558.6405748045 1.0 0.0 0.30191399645451733 23.906848693524246 -10.349131034246073 5.727099909505927 1.0001589783890097 0.15095699822730232 0.9133796896939526 0.1232558729196817 0.00025024280366524684 2.843946135986591e-05 0.11936380001471394 0.03978066192834695 4.475782416131525e-11 10.349131034246073 -0.8492019801617073 ESDLNGAQIK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESDLNGAQIKLR 12 1 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 27639900.0 10864000.0 10298000.0 6477900.0 True False 10519128.266652934 14410045.103360547 4781143.657165612 1.0 1.3698896655764097 0.45451899967057985 23.326511815848722 -6.797058316667518 1.4683092612146889 1.2048525871782911 0.44283991807052137 0.8232990949701257 0.15804763606881372 0.22498830562656713 0.9579688672783884 0.08469941703451574 0.19730685443720256 1.5956648684251133e-07 6.797058316667518 -0.7620126691077698 down ESDLNGAQIK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESDLNGAQIKLR 12 1 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 25185600.0 11997000.0 7693900.0 5494700.0 True False 16432615.106734581 7353958.05767507 4196965.026898701 1.0 0.44752207788650733 0.25540457192225346 23.970058755047138 -13.999999999998106 0.14730957718579127 3.6610150843956863 0.03735653722501284 0.9995754669254996 0.0065031658290907205 11.948635310354813 0.12073115137240079 9.10908681058442 0.19604664072570518 1.0000000000043602e-14 13.999999999998106 -3.6236585471706735 ESDLNGAQIK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESDLNGAQIKLR 12 1 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 30228800.0 10864000.0 14474000.0 4890800.0 True False 9033897.35680393 14396025.689135946 5913443.667495801 1.0 1.5935564818315653 0.6545838893157291 23.106917091282998 -6.735878800379159 1.7018905064406395 1.3548406918431013 0.6545240899178497 0.5862631552371029 0.24942297770425587 0.3253204889227413 1.8484990834502943 0.11602167565780559 0.2859932961056951 1.8370509421081582e-07 6.735878800379159 -0.7003166019252516 ESDTGLAPPALWDLAADK(ub)QTLQSEQPLQVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESDTGLAPPALWDLAADKQTLQSEQPLQVAR 31 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 35821800.0 18489000.0 4650800.0 12682000.0 True False 17902076.815366905 6507888.693601604 9360203.748155164 1.0 0.36352702318958424 0.5228557471120049 24.093623628093756 -10.423372966946475 9.098161755169963 1.0000031583476021 0.4431913851517609 0.9421431951225474 0.06504567916311702 4.16718091982679e-06 2.640677999503346e-07 0.06298056531976132 0.020993402678458593 3.7724807560231944e-11 10.423372966946475 -0.5568117731958413 ESDTGLAPPALWDLAADK(ub)QTLQSEQPLQVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESDTGLAPPALWDLAADKQTLQSEQPLQVAR 31 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 196581000.0 36945000.0 50416000.0 109220000.0 True False 56048266.04129013 41418870.897994086 87632619.12717345 1.0 0.7389857675076205 1.5635206103006913 25.740166405443365 -6.82159772044723 1.3651101621496473 0.8595409467358971 1.5821212906310684 0.8879847388415383 0.1151602371519615 0.19141393764739062 0.7004914671727295 0.0662872318301744 0.15270785132238374 1.5080032570853683e-07 6.82159772044723 0.7225803438951713 ESDTGLAPPALWDLAADK(ub)QTLQSEQPLQVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESDTGLAPPALWDLAADKQTLQSEQPLQVAR 31 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 38764600.0 18489000.0 10689000.0 9586600.0 True False 15374422.701578407 10631416.23539963 11591113.736569734 1.0 0.6915001910483547 0.7539218845192632 23.874028903528032 -10.770612657113185 7.0098425908787885 1.0068385402096092 0.722711037783932 0.9633843456777184 0.02548354964735769 0.002757168095067748 9.022438001330982e-05 0.02497901646843566 0.008224780282205517 1.6958496374112943e-11 10.770612657113185 -0.2841275024256772 ESDTGLAPPALWDLAADK(ub)QTLQSEQPLQVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESDTGLAPPALWDLAADKQTLQSEQPLQVAR 31 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 199555000.0 36945000.0 40310000.0 122300000.0 True False 47826030.79482559 38066713.06466216 100042654.90397072 1.0 0.7959412987452157 2.091803422557796 25.511292727535814 -6.866627354158944 1.1517029739402163 0.8866276758968112 2.163012186085523 0.9612042323788103 0.11205627730007876 0.1401342947394504 0.34950667874570723 0.07565037714886957 0.17813993170191433 1.3594794459243658e-07 6.866627354158944 1.276384510188712 up ESDVPLK(ub)TEEFEVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESDVPLKTEEFEVTK 15 1 Q969H8;M0QYN0;M0QXF7 Q969H8 MYDGF Myeloid-derived growth factor 1 17795200.0 3449200.0 3828000.0 10518000.0 True False 3339707.0339966225 5356540.362756282 7763020.266763591 1.0 1.6038952842956762 2.324461453576542 21.67129012138338 -6.9687806824411425 0.2858117496409755 0.8519636268953588 3.0985265044776718 0.9999712485321004 0.002903045167961081 0.07670035568572255 0.010439431333985984 0.012879699348540061 0.06566747375496682 1.0745319111081336e-07 6.9687806824411425 2.246562877582313 ESDVPLK(ub)TEEFEVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESDVPLKTEEFEVTK 15 1 Q969H8;M0QYN0;M0QXF7 Q969H8 MYDGF Myeloid-derived growth factor 1 81992300.0 5708300.0 19313000.0 56971000.0 True False 8659908.432629477 15866444.25684227 45710656.878723696 1.0 1.8321722891502463 5.278422657044678 23.045920339716155 -6.944077766535879 0.6204675787382251 0.9622938896333788 6.331024024481956 0.9986507110825377 0.06803431888250452 0.0859545780017316 0.04650100971380549 0.06848653359720579 0.29170884332609964 1.1374235958930728e-07 6.944077766535879 5.368730134848578 ESDVPLK(ub)TEEFEVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESDVPLKTEEFEVTK 15 1 Q969H8;M0QYN0;M0QXF7 Q969H8 MYDGF Myeloid-derived growth factor 1 14042200.0 3449200.0 3635600.0 6957400.0 True False 2868162.6254683468 3616014.301189905 8412160.172617 1.0 1.2607424241153133 2.932943933485419 21.451695396817655 -6.934442990664158 0.7093825331581589 0.9782749124155423 3.3185973310518175 0.9973415590141576 0.04415513554611608 0.09039567923564364 0.0668554940580003 0.04134917426740736 0.14778408711008398 1.162939198671786e-07 6.934442990664158 2.3403224186362754 up ESDVPLK(ub)TEEFEVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESDVPLKTEEFEVTK 15 1 Q969H8;M0QYN0;M0QXF7 Q969H8 MYDGF Myeloid-derived growth factor 1 87246200.0 5708300.0 22842900.0 58695000.0 True False 7389506.877415146 21571672.53447707 48013112.261558145 1.0 2.919230321093206 6.497471760707416 22.817046661808604 -6.961394179012276 0.4153177919672369 0.833632454245112 8.717019099654385 0.9998184633035204 0.03069469627869125 0.07920679422312911 0.019318510612133372 0.04616775087187716 0.2982626359246527 1.0929639083310971e-07 6.961394179012276 7.8833866454092725 ESEAVEWQQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESEAVEWQQK 10 0 P26038 P26038 MSN Moesin 0 11297100.0 1061100.0 5300200.0 4935800.0 False True 1391112.3757070154 4509430.820017785 4425090.763536823 1.0 3.2416006778215336 3.1809728968070075 20.40780753652767 -10.092990757340916 4.469701258075309 0.9998062648730983 3.2112867874315025 0.9994365313916083 0.02475118836781444 3826002.0633832538 5123241.0115828775 9488.495612379395 0.00905800776593295 8.072522100148483e-11 10.092990757340916 2.2114805225584044 ESEAVEWQQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESEAVEWQQK 10 0 P26038 P26038 MSN Moesin 0 10938640.0 2726300.0 770940.0 7441400.0 False True 2639755.0988011677 1078780.3623989895 5492274.102785192 1.0 0.4086668353776123 2.08059986522215 21.331972660220803 -6.811118239138232 1.4099413600104265 0.6781581828994655 2.110571910163676 0.8627025325494249 0.2564993066613728 0.20527857106830802 0.8040955387106941 0.14304148817676937 0.3307022308668169 1.5448337925090513e-07 6.811118239138232 1.4324137272642106 up ESEAVEWQQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESEAVEWQQK 10 0 P26038 P26038 MSN Moesin 0 9290800.0 1061100.0 3637000.0 4592700.0 False True 1453417.3451492896 3476305.314049339 3507998.8496255744 1.0 2.391814935779692 2.413621153850511 20.47101759805056 -10.796331078415019 0.7318526937282823 1.8445463797860107e-15 2.4095175507934226 0.9999713519007761 0.0035395724815781666 2.514633851267544 0.37799746675769186 4.416409525058636 0.0033063928792812724 1.5983390922673087e-11 10.796331078415019 2.409517550793421 ESEDFIVEQYK(ub)HLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESEDFIVEQYKHLR 14 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 18884000.0 6326300.0 8110900.0 4446800.0 True False 6125475.069341542 11349624.667784719 3282049.6788595133 1.0 1.8528562338928507 0.5358032873705446 22.546390307905448 -6.73191047794481 1.7162012447131831 1.5121633185743255 0.5363059582384495 0.5680555169982007 0.3584718714506422 0.3327050139141096 1.920618143970969 0.16546400544328807 0.40971250793449926 1.8539137352544357e-07 6.73191047794481 -0.975857360335876 ESEDFIVEQYK(ub)HLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESEDFIVEQYKHLR 14 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 49091100.0 5902300.0 12300000.0 30888800.0 True False 8954220.615929255 10104968.899661368 24783615.140958026 1.0 1.1285146226668763 2.7678137722973695 23.09413643342068 -6.9225321087820415 0.8057298950712796 0.9670240895539013 3.048195407571016 0.9948557886010484 0.05772109353347582 0.09670460153788911 0.09806295979462035 0.05041153021709597 0.1548625809558439 1.1952751518865748e-07 6.9225321087820415 2.0811713180171143 up ESEDFIVEQYK(ub)HLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESEDFIVEQYKHLR 14 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 14488100.0 4074900.0 7555000.0 2858200.0 True False 5581500.650031893 7221195.118955947 2183152.02647676 1.0 1.2937730498902094 0.391140691968617 22.41222162852796 -6.81906287167027 1.3759018958582712 1.1584963377951603 0.37182599012947865 0.8822109797437261 0.1290129459709838 0.19470828742536217 0.72453510598061 0.07368789339210872 0.1698844807380045 1.5168307639624607e-07 6.81906287167027 -0.7866703476656816 down ESEDFIVEQYK(ub)HLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESEDFIVEQYKHLR 14 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 23179300.0 6326300.0 9848800.0 7004200.0 True False 5260598.752609421 9795742.559566256 8468745.836238261 1.0 1.8620965065444808 1.60984447483996 22.326795583339724 -10.156558960997607 4.657146455139939 0.9999289354576553 1.735970490612272 0.9190273679688589 0.1029814611404146 72085419.57260941 11.22605690858427 67143.76404377836 0.03525329322606675 6.973343184552299e-11 10.156558960997607 0.7360415551546167 ESEDFIVEQYK(ub)HLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESEDFIVEQYKHLR 14 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 49589500.0 5902300.0 13407900.0 30279300.0 True False 7640643.701726857 12661738.578508647 24768778.091854453 1.0 1.6571560031842574 3.2417135334103433 22.86526275551313 -6.956232147980324 0.48563836181351266 0.9639125067478643 4.001653894254119 0.9996039036824225 0.018726326648656637 0.08107566232705712 0.026321789628641387 0.022603543465117223 0.13069384565245656 1.1060324068418481e-07 6.956232147980324 3.0377413875062547 ESEK(ub)TAESQTPTPSATSFFSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESEKTAESQTPTPSATSFFSGK 22 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 17331600.0 7045900.0 6302100.0 3983600.0 True False 6822231.761230662 8818561.395017331 2940175.6545616523 1.0 1.292621198407741 0.4309697702253484 22.701812335576975 -6.815074024112117 1.3930299035046494 1.1585531032793672 0.4140730704808873 0.8726639887110071 0.12766013478432947 0.19997323282758672 0.7637861698130117 0.07203699603070113 0.16629250634974285 1.5308265149369146e-07 6.815074024112117 -0.74448003279848 down ESEK(ub)TAESQTPTPSATSFFSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESEKTAESQTPTPSATSFFSGK 22 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 32557200.0 10129000.0 9953200.0 12475000.0 True False 15366433.52908994 8176973.695293458 10009310.782013262 1.0 0.5321321749652426 0.6513750092410708 23.873279025925214 -10.109714145942434 7.6033989831510995 1.0000000694582458 0.5917535921031724 0.9398624925072839 0.048680683243172616 5.731623183630388e-08 6.743380072630767e-09 0.04713487659663866 0.0157116229569005 7.767582132203259e-11 10.109714145942434 -0.40824647735507347 ESEK(ub)TAESQTPTPSATSFFSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESEKTAESQTPTPSATSFFSGK 22 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 18017100.0 7290100.0 5380700.0 5346300.0 True False 9985446.977544863 5142962.882404533 4083614.0505047655 1.0 0.5150458356015467 0.40895656045121875 23.25139557764985 -13.999999999999998 0.2135735238672722 3.8466802230654045 0.3485926172753227 0.9994923171049036 0.005797133712179735 12.832699876825924 0.14645258075583942 15.356007613201935 0.0613048227871927 1.0000000000000041e-14 13.999999999999998 -3.4980876057900816 ESEK(ub)TAESQTPTPSATSFFSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESEKTAESQTPTPSATSFFSGK 22 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 15450200.0 7045900.0 5984400.0 2419900.0 True False 5858978.036294625 5952160.849389611 2925889.901646576 1.0 1.0159042775920555 0.49938570916660874 22.48221761101125 -6.899793779831964 0.962550217954063 1.0215966349838976 0.4453909897132969 0.9864640250860517 0.027902647348424608 0.11155793214857736 0.17826833942769835 0.021749356683203002 0.056531066144345464 1.259523341237117e-07 6.899793779831964 -0.5762056452706008 down ESEK(ub)TAESQTPTPSATSFFSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESEKTAESQTPTPSATSFFSGK 22 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 32339000.0 10129000.0 9184000.0 13026000.0 True False 13112190.172439802 8672902.326615177 10655401.658046784 1.0 0.6614381131265578 0.8126332456985803 23.644405348017663 -10.145016604826244 5.00206957847224 1.000013906259882 0.737035679411992 0.801321809067107 0.06172515440098669 9.57297525195768e-06 1.6362739098728618e-06 0.05976828249952108 0.019921707919472217 7.161160296910161e-11 10.145016604826244 -0.2629782268478901 ESELYQK(ub)EVSHLNALEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESELYQKEVSHLNALEER 18 1 P28340;M0R2B7;A0A087WYJ2;M0R3H8 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 57200400.0 12804900.0 14389800.0 30005700.0 True False 16787347.902828 12242897.931001063 26900997.998998504 1.0 0.7292931558854882 1.6024566926659545 24.000870992779827 -6.823427826897345 1.3569206778490368 0.8545730218654829 1.6229659931510074 0.892096223720991 0.11987908263314243 0.1890655623068539 0.6830597357494242 0.06940658820701025 0.15984827167658203 1.5016619382734828e-07 6.823427826897345 0.7683929712855245 ESELYQK(ub)EVSHLNALEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESELYQKEVSHLNALEER 18 1 P28340;M0R2B7;A0A087WYJ2;M0R3H8 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 84435100.0 8755700.0 12863400.0 62816000.0 True False 8477755.096127873 17999822.70174483 46362605.16039377 1.0 2.1231826701346987 5.4687360786783525 23.01525086000297 -6.951611220282119 0.5408659996603581 0.9510234545069897 6.795622482698756 0.9993217350302661 0.049432304178292336 0.0828451367402263 0.03333416662428883 0.054305490657274864 0.27709772144139044 1.1178635096034231e-07 6.951611220282119 5.844599028191767 ESELYQK(ub)EVSHLNALEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESELYQKEVSHLNALEER 18 1 P28340;M0R2B7;A0A087WYJ2;M0R3H8 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 316223000.0 10401000.0 57738000.0 248084000.0 True False 15779077.414953524 47434202.79094693 199050088.6609201 1.0 3.006145514312165 12.614811590459922 23.911509519259873 -6.940769355835811 0.6523737337164368 0.893410615639912 15.26561820032455 0.9982628497120436 0.21127248629535084 0.08741761856931632 0.053025882249968924 0.20687568936897327 0.8242368949869223 1.1461214595255945e-07 6.940769355835811 14.372207584684638 ESELYQK(ub)EVSHLNALEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESELYQKEVSHLNALEER 18 1 P28340;M0R2B7;A0A087WYJ2;M0R3H8 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 62494300.0 12804900.0 17204500.0 32484900.0 True False 17539217.569411147 16444348.302326612 24812635.66751624 1.0 0.937575934459356 1.4146945591683704 24.06408105430272 -6.873976068179257 1.1128046523376647 0.9636831368967432 1.4448377724101658 0.9684949155259652 0.03758343730294763 0.13310186687465383 0.30564805235675796 0.0261417996965359 0.06235831957136257 1.3366691717435135e-07 6.873976068179257 0.4811546355134225 ESELYQK(ub)EVSHLNALEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESELYQKEVSHLNALEER 18 1 P28340;M0R2B7;A0A087WYJ2;M0R3H8 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 61134900.0 8755700.0 17418200.0 34961000.0 True False 7280752.493277638 17324364.69935799 42271183.45859997 1.0 2.3794744726391506 5.805881122539079 22.795656135437245 -6.955600357811759 0.49354840227438945 0.927371429602035 7.404156804086075 0.9995706343192065 0.04186588170263981 0.08131183260853053 0.027235952965642584 0.04971479834391409 0.2826057758215651 1.107642579091482e-07 6.955600357811759 6.47678537448404 ESELYQK(ub)EVSHLNALEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESELYQKEVSHLNALEER 18 1 P28340;M0R2B7;A0A087WYJ2;M0R3H8 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 410766000.0 10401000.0 36995000.0 363370000.0 True False 13464299.534361359 34936195.728781335 297240388.4910535 1.0 2.5947280539639626 22.076186565256197 23.682635841352322 -6.9231372909137905 0.8011101445643259 0.6167942467145276 25.45626593068058 0.9950090403045138 0.6769137750745621 0.09636085882700947 0.09630393387256454 0.5931387259443454 1.8337245260235708 1.1936107158089604e-07 6.9231372909137905 24.839471683966053 ESENSGDSGYPSEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESENSGDSGYPSEKR 15 1 O00418 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 3781500.0 1340000.0 1634800.0 806700.0 True False 1756752.9765784577 1390894.2124004883 723230.4224128107 1.0 0.7917414861077767 0.4116858955442964 20.744479912338093 -6.961796580489822 0.4093346110283284 1.0188582166453433 0.17048036276702605 0.9998311214477682 0.0031652378749462444 0.07906558170000093 0.018805825118873402 0.004893051489561823 0.03173863474145209 1.0919516767307938e-07 6.961796580489822 -0.8483778538783172 down ESENSGDSGYPSEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESENSGDSGYPSEKR 15 1 O00418 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 3795200.0 1340000.0 1463600.0 991600.0 True False 1835434.2121383934 1398933.3125220274 757404.5026430466 1.0 0.7621811249187648 0.41265685124209595 20.807689973860985 -6.96559410738203 0.3477060155796918 1.0346814134655546 0.12840378504324648 0.9999248721020294 0.002090825342865388 0.07775994065263069 0.014152374440832052 0.004826485032715506 0.03008884582046539 1.0824451344003393e-07 6.96559410738203 -0.9062776284223082 down ESENSGDSGYPSEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESENSGDSGYPSEKR 15 1 O00418 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 9705200.0 1615500.0 1388100.0 6701600.0 True False 2091296.5962658208 1310851.0147620328 5481977.5642228145 1.0 0.6268125798620163 2.6213295493385917 20.9959662546937 -6.858336904110612 1.194139790744878 0.7983580915814954 2.714879049836492 0.9515868344651576 0.1904961091231593 0.14852095639199345 0.40338878179768267 0.12450608900415619 0.29010628817477074 1.3856804696657898e-07 6.858336904110612 1.9165209582549967 up ESESAPGDFSLSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESESAPGDFSLSVK 14 0 P62993;J3KT38 P62993 GRB2 Growth factor receptor-bound protein 2 0 14278800.0 2846300.0 5546900.0 5885600.0 False True 3731526.8636084115 4719324.141646854 5276614.5706617525 1.0 1.2647166466016637 1.4140631338130663 21.831334641580742 -11.693028916556417 0.08548705068896435 3.3397215283436756e-26 1.8729568112972939 0.9999181311165916 0.0015491563067936021 4.946830341409713 0.06073838203950929 1.2522818043203916 0.32847322435818893 2.0275477151584713e-12 11.693028916556417 1.8729568112972939 ESESAPGDFSLSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESESAPGDFSLSVK 14 0 P62993;J3KT38 P62993 GRB2 Growth factor receptor-bound protein 2 0 4715000.0 3378400.0 1336600.0 0.0 False True 3271154.541242662 1870311.350276918 0.0 1.0 0.5717587862927488 0.0 21.64136848851793 -7.723856539802599 0.6405622624952496 1.0012133804184267 4.0766975846495696e-19 0.9876034432749703 0.045610065349613114 0.11949031529223242 0.15221664519977188 0.04291780783457146 0.07790939204500683 1.8886151109974016e-08 7.723856539802599 -1.0012133804184267 down ESESAPGDFSLSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESESAPGDFSLSVK 14 0 P62993;J3KT38 P62993 GRB2 Growth factor receptor-bound protein 2 0 12673800.0 2846300.0 4153600.0 5673900.0 False True 3898654.0283653107 3970080.2178815883 4333841.677638544 1.0 1.0183207304358386 1.1116251008955789 21.894544703103634 -6.939395404501759 0.6651618437317947 0.9989410001735035 1.1363452465604418 0.9980836590549848 0.00213967649764141 0.0880434548185446 0.055873292312715976 0.0020734001745975413 0.0080521437038237 1.1497531166583231e-07 6.939395404501759 0.13740424638693827 ESESCDCLQGFQLTHSLGGGTGSGMGTLLISK ddPTM_RPMI8226_Bortezomib_8h_R1 2 ESESCDCLQGFQLTHSLGGGTGSGMGTLLISK 32 0 Q13885;Q9BVA1 Q13885;Q9BVA1 TUBB2A;TUBB2B Tubulin beta-2A chain;Tubulin beta-2B chain 0 228568500.0 42683400.0 129347000.0 56538100.0 False True 64753838.37452434 106264017.25727624 45363319.75347049 1.0 1.6410458426057253 0.700550282302917 25.948462377315956 -6.723217223817213 1.7480068184042756 1.3886638785219203 0.701770456239835 0.5275459641285891 0.26965324147186887 0.34909774524001597 2.086361338673185 0.12241380817162964 0.30611663730912964 1.891397349841626e-07 6.723217223817213 -0.6868934222820853 ESETNK(ub)GAFSLSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESETNKGAFSLSVK 14 1 E9PJX5;P51451 E9PJX5 BLK Non-specific protein-tyrosine kinase;Tyrosine-protein kinase Blk 1 7866700.0 3159600.0 2420700.0 2286400.0 True False 3059300.227477599 3387298.133783737 1687523.2494702695 1.0 1.1072133762355758 0.5516043290924856 21.544770263483848 -6.856685072741527 1.202367744268838 1.057730829273004 0.5263527579549695 0.9494846661125692 0.05408980179813039 0.15025359089835383 0.4146601500615164 0.035131192794811264 0.08172471044477768 1.3909609164641873e-07 6.856685072741527 -0.5313780713180346 ESETNK(ub)GAFSLSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESETNKGAFSLSVK 14 1 E9PJX5;P51451 E9PJX5 BLK Non-specific protein-tyrosine kinase;Tyrosine-protein kinase Blk 1 22538000.0 5123200.0 11690000.0 5724800.0 True False 7772268.956089783 9603828.16561312 4593290.770731025 1.0 1.2356530917639257 0.5909845370356178 22.889904394964777 -6.807790580258747 1.4239424109624859 1.1287660621534454 0.5802809620135659 0.8539527441049927 0.10178409111315163 0.20982375393145444 0.8389353333048699 0.05621423138010325 0.1301615711811689 1.5567161097016195e-07 6.807790580258747 -0.5484851001398795 ESETNK(ub)GAFSLSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESETNKGAFSLSVK 14 1 E9PJX5;P51451 E9PJX5 BLK Non-specific protein-tyrosine kinase;Tyrosine-protein kinase Blk 1 7173400.0 2913000.0 2295000.0 1965400.0 True False 3990014.820865035 2193599.311449885 1501212.998683587 1.0 0.5497722213909754 0.3762424617656242 21.9279626746562 -13.999999999999998 0.13200342822143493 3.1404915653175305 0.1392977746987462 0.9996366425994908 0.005010748806021855 11.93415343334749 0.11317806365013561 6.616349660671339 0.21089184836961336 1.0000000000000041e-14 13.999999999999998 -3.0011937906187844 ESETNK(ub)GAFSLSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESETNKGAFSLSVK 14 1 E9PJX5;P51451 E9PJX5 BLK Non-specific protein-tyrosine kinase;Tyrosine-protein kinase Blk 1 6707600.0 3159600.0 2184200.0 1363800.0 True False 2627347.3940130444 2172433.2810702473 1648964.2745012606 1.0 0.8268542203518982 0.6276156241305461 21.325175538918124 -6.96928820526821 0.27465409723926 1.0468166002623052 0.40162594902838733 0.9999762852908076 0.0007409120044392137 0.07653436025009668 0.009853830727168873 0.0037972770058925806 0.01841433767339125 1.0732769309772503e-07 6.96928820526821 -0.6451906512339178 ESEVK(ub)ALCAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESEVKALCAK 10 1 H3BTA2;P60510;H3BV22;I3L4X0;H3BPN5;H3BVE3 H3BTA2 PPP4C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 4 catalytic subunit 1 76682600.0 26584300.0 20889200.0 29209100.0 True False 34852274.74272742 17772612.785463843 26186822.525471676 1.0 0.5099412568234856 0.7513662370326645 25.054749485382786 -10.12742512592341 5.208744659321442 1.00001052964822 0.6306537469277175 0.7573184263177768 0.09856133544691995 1.2052219437250908e-05 2.0190272850478157e-06 0.0954343208340705 0.031810534230310245 7.45718425735097e-11 10.12742512592341 -0.36935678272050254 ESEVK(ub)ALCAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESEVKALCAK 10 1 H3BTA2;P60510;H3BV22;I3L4X0;H3BPN5;H3BVE3 H3BTA2 PPP4C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 4 catalytic subunit 1 60709900.0 26543700.0 15214100.0 18952100.0 True False 25701084.772786777 21289169.470483355 13987976.459187144 1.0 0.8283373895962977 0.5442562671128228 24.615325917144013 -6.963573015210444 0.3817538628074096 1.0191328951618457 0.3433869372261744 0.9998806363068178 0.0020532395522182066 0.0784486271804195 0.01658847623702817 0.003690641041299048 0.023984622353842553 1.0874942886590628e-07 6.963573015210444 -0.6757459579356713 ESEVK(ub)ALCAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESEVKALCAK 10 1 H3BTA2;P60510;H3BV22;I3L4X0;H3BPN5;H3BVE3 H3BTA2 PPP4C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 4 catalytic subunit 1 287656900.0 71170900.0 71425000.0 145061000.0 True False 107971458.58974294 58678650.70392787 116389629.76750506 1.0 0.5434644624639924 1.077966633846714 26.686074756738495 -6.680536669280241 1.8999137249178786 0.7112771277514647 1.0759411322661365 0.3265171990435983 0.1934693332786153 0.43738770687642836 3.0529513047138295 0.08169441034342478 0.21532077921333886 2.086715926415288e-07 6.680536669280241 0.36466400451467185 ESEVK(ub)ALCAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESEVKALCAK 10 1 H3BTA2;P60510;H3BV22;I3L4X0;H3BPN5;H3BVE3 H3BTA2 PPP4C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 4 catalytic subunit 1 69058100.0 26584300.0 16716000.0 25757800.0 True False 36413234.12369458 15977431.847580075 19674338.138542827 1.0 0.4387809056813041 0.540307352862691 25.117959546905677 -9.939712666783397 5.535947025934712 1.000000568623447 0.48954412927241614 0.9711858643738116 0.041447998502537574 3.525008439722175e-07 6.751473759988528e-08 0.04013190639766107 0.013377283993935004 1.1489135018185574e-10 9.939712666783397 -0.5104564393510309 ESEVK(ub)ALCAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESEVKALCAK 10 1 H3BTA2;P60510;H3BV22;I3L4X0;H3BPN5;H3BVE3 H3BTA2 PPP4C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 4 catalytic subunit 1 85618300.0 26543700.0 14488400.0 44586200.0 True False 22072262.63529055 14410348.113477778 53908968.27670346 1.0 0.6528713594789141 2.4423852310687146 24.39573119257829 -6.85639738618359 1.2037697365247022 0.8131799130128812 2.5232800796781953 0.9491134755749698 0.1747877614346764 0.15055888710395354 0.4166256303330709 0.11340176371540378 0.26373656034104936 1.391882625907971e-07 6.85639738618359 1.7101001666653142 up ESEVK(ub)ALCAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESEVKALCAK 10 1 H3BTA2;P60510;H3BV22;I3L4X0;H3BPN5;H3BVE3 H3BTA2 PPP4C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 4 catalytic subunit 1 302175100.0 71170900.0 74076200.0 156928000.0 True False 92132133.03817703 69953794.35178684 128368714.21725515 1.0 0.7592768347477628 1.393310997847653 26.457201078830945 -6.803825026819238 1.4401772665687222 0.867813712599907 1.4029177150271905 0.8431001693884009 0.10351435252125096 0.2153611380851738 0.8814083819065288 0.056533022864054976 0.1311848294743683 1.5709956162736477e-07 6.803825026819238 0.5351040024272835 ESEVK(ub)ALCAK(ub)AR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESEVKALCAKAR 12 2 H3BTA2;P60510;H3BV22;I3L4X0;H3BPN5;H3BVE3 H3BTA2 PPP4C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 4 catalytic subunit 2 34628800.0 8210800.0 10765000.0 15653000.0 True False 10764438.313500319 9158903.961641349 14033377.714178402 1.0 0.850848292767364 1.3036795144785505 23.359769706106928 -6.817951706653351 1.3805634824215383 0.9194325800137089 1.3131478382207795 0.8796125611476997 0.0653763692848322 0.19617688342917486 0.7352257897447743 0.03721594697877846 0.0858333916366352 1.52071662331987e-07 6.817951706653351 0.39371525820707065 ESEVK(ub)ALCAK(ub)AR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESEVKALCAKAR 12 2 H3BTA2;P60510;H3BV22;I3L4X0;H3BPN5;H3BVE3 H3BTA2 PPP4C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 4 catalytic subunit 2 40116700.0 13597000.0 7026700.0 19493000.0 True False 13165370.677621502 9832497.953756412 14387198.522534953 1.0 0.7468455081534235 1.0928061863833667 23.650244805970583 -6.710557792224222 1.7932937423856798 0.844454788176681 1.09200428559693 0.46772607280382517 0.10666856018474419 0.3739503383057926 2.344601981913226 0.047329918728356166 0.12015550644869184 1.9473418969653894e-07 6.710557792224222 0.24754949742024912 ESEVK(ub)ALCAK(ub)AR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESEVKALCAKAR 12 2 H3BTA2;P60510;H3BV22;I3L4X0;H3BPN5;H3BVE3 H3BTA2 PPP4C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 4 catalytic subunit 2 217786000.0 27383000.0 51443000.0 138960000.0 True False 41542012.965452604 42262594.72400645 111494495.09166838 1.0 1.017345855607746 2.683897267674295 25.308067789515768 -6.909176020612421 0.9013290901600627 0.9470459993190491 2.895516916430548 0.990606861841621 0.07654018918447682 0.10496537645422345 0.1417419853429529 0.062410296166444605 0.1713125286554949 1.232605154100846e-07 6.909176020612421 1.9484709171114991 up ESEVK(ub)ALCAK(ub)AR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESEVKALCAKAR 12 2 H3BTA2;P60510;H3BV22;I3L4X0;H3BPN5;H3BVE3 H3BTA2 PPP4C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 4 catalytic subunit 2 36948800.0 8210800.0 10652000.0 18086000.0 True False 11246554.648526825 10181359.4185465 13814459.292862179 1.0 0.9052869733647847 1.2283281168843758 23.42297976762982 -6.828204481373262 1.3358274854472667 0.949324005159292 1.2367114381217184 0.9022477587918099 0.04239244237827558 0.18304062480920144 0.6394079277288381 0.024920914272721282 0.057358336488563984 1.4852361753267366e-07 6.828204481373262 0.2873874329624263 ESEVK(ub)ALCAK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESEVKALCAKAR 12 2 H3BTA2;P60510;H3BV22;I3L4X0;H3BPN5;H3BVE3 H3BTA2 PPP4C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 4 catalytic subunit 2 58300900.0 13597000.0 9052900.0 35651000.0 True False 11306507.949232608 9004130.230840035 43105459.26840045 1.0 0.7963670366897996 3.812446730851686 23.43065008140486 -6.890738583306487 1.0179843827920803 0.8408006086624484 4.075661229129933 0.9813674851884199 0.18786763216322452 0.11854667572118736 0.21835451469121878 0.14047636504044633 0.35116038613920797 1.2860605508096314e-07 6.890738583306487 3.234860620467485 up ESEVK(ub)ALCAK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESEVKALCAKAR 12 2 H3BTA2;P60510;H3BV22;I3L4X0;H3BPN5;H3BVE3 H3BTA2 PPP4C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 4 catalytic subunit 2 165317000.0 27383000.0 49547000.0 88387000.0 True False 35447833.29962669 46789665.89468659 72301472.92720574 1.0 1.3199584160530156 2.0396584557388775 25.079194111608217 -6.9576839904418915 0.4669354755731211 0.9804135318828051 2.4085554880009843 0.9996744058978652 0.007845101501481414 0.08053913022465517 0.024269048819439334 0.009894677375024197 0.05941480988128374 1.1023411240707747e-07 6.9576839904418915 1.4281419561181792 up ESFDGSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESFDGSVR 8 0 P19338;H7BY16 P19338 NCL Nucleolin 0 24667400.0 1688400.0 14671000.0 8308000.0 False True 2213508.7504888605 12482143.987110093 7448367.85596335 1.0 5.639075962249244 3.364959751940603 21.077903646063287 -9.991399231042156 11.231674643872207 1.0000000015577335 4.502017856328498 0.7597259706662082 0.9284040551746614 0.0 0.0 0.8989233610607239 0.2996411203535746 1.0200014025972919e-10 9.991399231042156 3.5020178547707648 ESFDGSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESFDGSVR 8 0 P19338;H7BY16 P19338 NCL Nucleolin 0 24804900.0 5972400.0 2483500.0 16349000.0 False True 5782809.431126473 3475174.5012814105 12066706.440513212 1.0 0.600949165396318 2.0866512348761 22.463339129114804 -6.83520708544649 1.304426778655492 0.7874146060285466 2.1310717371852923 0.9159039717017624 0.18206200059739389 0.17447017653091718 0.5787151281294466 0.10952082049742003 0.2520878553569 1.4614801279921424e-07 6.83520708544649 1.3436571311567458 up ESFDGSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESFDGSVR 8 0 P19338;H7BY16 P19338 NCL Nucleolin 0 17415600.0 1688400.0 6651500.0 9075700.0 False True 2312647.1072943793 6357614.7364309095 6932206.579908739 1.0 2.7490639260863428 2.997520269324139 21.14111370758618 -10.284738219902286 0.42294190867080295 5.1854711830030475e-20 3.0125728576940145 0.9992144674431355 0.0249130822782306 1.6572828328221507 0.19616000124704047 1.9679691676730786 0.05951982574044648 5.191128507890981e-11 10.284738219902286 3.0125728576940145 ESFDGSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESFDGSVR 8 0 P19338;H7BY16 P19338 NCL Nucleolin 0 7458950.0 5972400.0 887880.0 598670.0 False True 4966315.22218113 883096.8142096198 723849.1290626705 1.0 0.1778173101589345 0.14575174886800016 22.24374440454908 -13.167558558224577 0.4719922821627172 9.999999997508072 0.14652935514684784 0.999907760019701 0.003797053488824546 17.861891735807593 0.2370658122782936 164.1606695916082 0.0069033215460164625 6.79894365065344e-14 13.167558558224577 -9.853470642361223 ESFNPESYELDK(ub)SFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESFNPESYELDKSFR 15 1 P49903-4;P49903;Q5T5U6;P49903-2 P49903-4 SEPHS1 Selenide, water dikinase 1 1 5311900.0 1981500.0 2148900.0 1181500.0 True False 1647705.0453338537 2137323.4491767455 1428546.1873612253 1.0 1.297151729449057 0.8669914505674023 20.65202657900625 -6.720830717367434 1.756283375008088 1.1806137425202314 0.8676252364254551 0.5165785571654455 0.12502858150286644 0.35364259446393476 2.1322580890390066 0.056515498398829786 0.14173888107719518 1.9018194412277712e-07 6.720830717367434 -0.31298850609477635 ESGAK(ub)EVHIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESGAKEVHIR 10 1 Q06203 Q06203 PPAT Amidophosphoribosyltransferase 1 4081400.0 681100.0 1177300.0 2223000.0 True False 659478.8533152904 1647402.0295383944 1640729.6114294997 1.0 2.49803617091993 2.487918457402125 19.330966873555344 -10.041396535066529 4.7676680488189955 0.9999599703430364 2.492977314194171 0.9999655566395897 0.004130539360485331 1429264.6975634003 0.029377238710494642 630.0634481774705 0.0014139934719151527 9.090828502707477e-11 10.041396535066529 1.4930173438511345 ESGAK(ub)EVHIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESGAKEVHIR 10 1 Q06203 Q06203 PPAT Amidophosphoribosyltransferase 1 2808770.0 466040.0 555230.0 1787500.0 True False 603297.9670218022 524330.9624136043 1462193.3412988335 1.0 0.8691077893101135 2.4236669460647997 19.202511195252242 -6.886443686169311 1.0431672698107417 0.9092128693025572 2.5484276667951224 0.9785236140907905 0.10317077452456798 0.12207703730005472 0.23907077230937582 0.07568591682918017 0.18642926286484052 1.29884197035503e-07 6.886443686169311 1.6392147974925653 up ESGCSFVLALMQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESGCSFVLALMQK 13 0 P07384 P07384 CAPN1 Calpain-1 catalytic subunit 0 6896800.0 1455400.0 2477800.0 2963600.0 False True 1908043.4941136467 2108121.898388753 2656955.1008585654 1.0 1.104860504958274 1.3925023769402147 20.863662627474138 -6.953444226788012 0.5196591308037288 0.9950993062586726 1.5150925536242523 0.9994445845752771 0.003910484848542697 0.08213150403767708 0.030461586328824525 0.004432486370597363 0.023758573815263223 1.1131553378883264e-07 6.953444226788012 0.5199932473655797 ESGCSFVLALMQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESGCSFVLALMQK 13 0 P07384 P07384 CAPN1 Calpain-1 catalytic subunit 0 3986200.0 1455400.0 1519600.0 1011200.0 False True 1993500.710706132 1452459.0473547915 772375.3863177177 1.0 0.7285972056866263 0.3874467574401462 20.92687268899703 -6.96802768406031 0.30159835392315143 1.0580542118568403 0.04727570271509558 0.9999626527735017 0.001531548392768903 0.07694800199958536 0.011308634183179645 0.005615402450706847 0.030544843354594592 1.0763965966445197e-07 6.96802768406031 -1.0107785091417447 down ESGLQAAHPNSIFLIDHAWTCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESGLQAAHPNSIFLIDHAWTCR 22 0 Q14166 Q14166 TTLL12 Tubulin--tyrosine ligase-like protein 12 0 11145200.0 1945400.0 3835300.0 5364500.0 False True 2664666.952458234 3665843.7643589303 4097515.585345526 1.0 1.3757230564881968 1.5377214708072418 21.345523796093698 -11.84375770728786 0.14202359599776213 9.98909611685128e-18 1.759877451913154 0.9996475834584955 0.004228178941005093 5.07357723872371 0.0957003827919798 1.6970023654336397 0.17000719536739614 1.4329871392383103e-12 11.84375770728786 1.759877451913154 ESGVDIAAGNMLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESGVDIAAGNMLVK 14 0 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 10801500.0 1849500.0 2581300.0 6370700.0 False True 1790788.6348651138 3612026.551301671 4702022.553096676 1.0 2.0170032805539537 2.625671428527266 20.772163636727985 -8.787498732842574 0.17590106313956183 2.0016336375136953e-24 3.459553358037257 0.9997587951692464 0.010415243062627241 0.3204413283303937 0.05259172493680018 0.5406114309549671 0.366195162491407 1.6311776685696382e-09 8.787498732842574 3.459553358037257 ESGVDIAAGNMLVK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESGVDIAAGNMLVKK 15 1 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 5354900.0 2068700.0 1472500.0 1813700.0 True False 2712085.733319295 1252808.7397600433 1626035.722238894 1.0 0.4619355223062005 0.5995517406630081 21.3709713543912 -10.25578710279023 8.340734665391441 1.0000002911574215 0.5307436314846846 0.9394054936523025 0.05618158588426839 3.0421399907398393e-07 2.716300326904128e-08 0.05439762026098945 0.018132528874441087 5.548976648666116e-11 10.25578710279023 -0.4692566596727369 ESGVDIAAGNMLVK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESGVDIAAGNMLVKK 15 1 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 10073100.0 3389200.0 2923000.0 3760900.0 True False 3281611.7011542846 4090169.1432436267 2775807.465418446 1.0 1.2463903458794157 0.8458671281681724 21.645973110442522 -6.740266859596267 1.6856786304722777 1.1465572353961468 0.8456175047444666 0.6061322360767577 0.10352235959380202 0.31734649019979017 1.7706764354275994 0.04858113071045545 0.11918068829257367 1.8185830560745077e-07 6.740266859596267 -0.3009397306516802 ESGVDIAAGNMLVK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESGVDIAAGNMLVKK 15 1 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 6335300.0 2068700.0 1170900.0 3095700.0 True False 2833554.2945154435 1119165.7663514907 2364559.4179428015 1.0 0.3949688800803005 0.8344853043824088 21.434181415914093 -9.778664543169294 6.063012719898703 1.0000000151633825 0.6147270922306722 0.506058645118917 0.17943182885471154 3.679938077233215e-08 7.258814582608105e-09 0.17373412640999433 0.05791137374410732 1.664697996420863e-10 9.778664543169294 -0.3852729229327103 ESGVDIAAGNMLVK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESGVDIAAGNMLVKK 15 1 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 9399500.0 3389200.0 3754700.0 2255600.0 True False 2818269.9670176636 3734472.6858504005 2727235.531283944 1.0 1.325094022061441 0.9676984686353332 21.4263783858768 -6.667368703674062 1.9477297657927828 1.2079843678087074 0.9691899296399399 0.26708142723645023 0.1381789862202764 0.46713911479917664 3.414297179332902 0.05717943073908628 0.15323782638738778 2.1509548597980173e-07 6.667368703674062 -0.23879443816876755 ESGYAGK(ub)ISQMPVILTPLHFDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESGYAGKISQMPVILTPLHFDR 22 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 8398600.0 1395400.0 4995800.0 2007400.0 True False 1911317.0892670993 4775069.0370986285 1533293.4637007383 1.0 2.4983133693057935 0.8022182568820565 20.866135711932735 -6.673552474891003 1.9250246089152445 1.953460213646357 0.8090039686882509 0.29472553077943875 0.63594024152411 0.45304166963766174 3.2400255624318626 0.26565048321338336 0.706416947854493 2.1205451565882457e-07 6.673552474891003 -1.1444562449581062 ESGYAGK(ub)ISQMPVILTPLHFDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESGYAGKISQMPVILTPLHFDR 22 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 15690800.0 7071400.0 6166900.0 2452500.0 True False 5880182.41613617 6133677.685666192 2965306.410921207 1.0 1.043110102984967 0.5042881667725014 22.48742948063971 -6.887536362773398 1.0368787280670417 1.0306846223416943 0.46012649388631793 0.9792727882981421 0.03519712021376233 0.12116346998765223 0.2337226847347997 0.02594508696923408 0.06413172749476721 1.2955782163104342e-07 6.887536362773398 -0.5705581284553765 ESGYAGK(ub)ISQMPVILTPLHFDRDPLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESGYAGKISQMPVILTPLHFDRDPLQK 27 2 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 8462700.0 3262200.0 3949100.0 1251400.0 True False 4276775.791189734 3359909.67347123 1121917.1322764251 1.0 0.7856174458321451 0.2623277878133342 22.028092145624854 -6.9559722039348335 0.48890548106303616 1.0115662069919988 0.014230338556949988 0.9995904219332115 0.006270349872439612 0.08117257604785366 0.026695967458759694 0.0075165868542427395 0.04315946498576692 1.106694613270861e-07 6.9559722039348335 -0.9973358684350488 down ESGYAGK(ub)ISQMPVILTPLHFDRDPLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESGYAGKISQMPVILTPLHFDRDPLQK 27 2 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 120489000.0 56677000.0 41556000.0 22256000.0 True False 54877819.65842123 58149527.511677206 16426485.934311718 1.0 1.0596180364602716 0.29932832675488785 25.709719827382788 -6.88794812543426 1.0344723456657332 1.0428834869711072 0.23651254839368935 0.9795511007686373 0.0493650472629952 0.12082259924276365 0.23171295575712272 0.036455223421488575 0.09023504776760544 1.2943504366837635e-07 6.88794812543426 -0.8063709385774178 down ESGYAGK(ub)ISQMPVILTPLHFDRDPLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESGYAGKISQMPVILTPLHFDRDPLQK 27 2 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 138689000.0 42018000.0 45190000.0 51481000.0 True False 63744377.92726822 37125491.428918496 41305757.78507609 1.0 0.5824120124174458 0.6479906013390796 25.925794770196838 -10.610345481946155 6.498600442218905 1.0011298598212526 0.615201306878281 0.9786813569801178 0.02677234681828943 0.00043942184157053446 2.634760608796009e-05 0.025990883714053902 0.00864073778051034 2.4527569673582615e-11 10.610345481946155 -0.38592855294297157 ESGYAGK(ub)ISQMPVILTPLHFDRDPLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESGYAGKISQMPVILTPLHFDRDPLQK 27 2 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 25765100.0 3262200.0 12836400.0 9666500.0 True False 4468323.497640198 12269245.403701656 7383471.787816666 1.0 2.7458274697839724 1.6524031421887897 22.091302207147745 -10.250297299862893 4.9647510980094856 0.999772608809991 2.199115305987332 0.6159094061613439 0.4463886124956261 0.0011237383530715228 0.00016969067436372703 0.4322928865281793 0.14407130517721214 5.6195650153887195e-11 10.250297299862893 1.1993426971773409 ESGYAGK(ub)ISQMPVILTPLHFDRDPLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESGYAGKISQMPVILTPLHFDRDPLQK 27 2 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 113686900.0 56677000.0 48721000.0 8288900.0 True False 47129436.716824025 48458530.302638635 10022070.666456597 1.0 1.0282009223619717 0.21264991403724903 25.490125102817064 -6.898890824896533 0.9682650377100136 1.0349472727466467 0.12895003411505326 0.9860060139202131 0.044713919446736985 0.11222592851528336 0.18206539091782836 0.034706243282789914 0.08980642154740863 1.2621447789358189e-07 6.898890824896533 -0.9059972386315934 down ESGYAGK(ub)ISQMPVILTPLHFDRDPLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESGYAGKISQMPVILTPLHFDRDPLQK 27 2 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 129888000.0 42018000.0 63609000.0 24261000.0 True False 54393129.29860544 60069103.23319513 19845746.9388817 1.0 1.1043509356380277 0.36485760600264844 25.696921092289287 -6.871165004421421 1.127978797139235 1.0594482341157891 0.3205915798579616 0.9658289122772608 0.0604091441050173 0.13573938578469388 0.32208501539894047 0.041534600658274294 0.09853397963032616 1.3453491094125046e-07 6.871165004421421 -0.7388566542578275 down ESHTAVVYTEK(ub)DNKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESHTAVVYTEKDNKK 15 2 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 2346490.0 482880.0 1063600.0 800010.0 True False 633060.3562165721 904915.0258803276 717232.6394377995 1.0 1.4294293063752566 1.1329609134337133 19.27198352774492 -10.20630777734084 4.519724291272598 0.9999272697288837 1.2811951099080132 0.5453496247463387 0.12103271460720402 8.872916770756935e-05 1.5581219372194352e-05 0.11721966560893256 0.03906314066660952 6.218594274472007e-11 10.20630777734084 0.28126784017912954 ESHTAVVYTEK(ub)DNKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESHTAVVYTEKDNKK 15 2 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 2517080.0 482880.0 1000500.0 1033700.0 True False 661413.7853413345 956294.6017889376 789561.3497197641 1.0 1.445834095059607 1.1937479490426657 19.33519358926781 -10.144398330737367 4.478266492906956 0.9999572409678991 1.3197910220589795 0.6821078835321 0.10291373822446316 4.8427974357472536e-05 9.252403374559209e-06 0.09966045850358862 0.03321526617739136 7.171362390510807e-11 10.144398330737367 0.3198337810910804 ESHTAVVYTEK(ub)DNKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESHTAVVYTEKDNKK 15 2 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 2269620.0 702670.0 1081300.0 485650.0 True False 584301.2385590408 1075474.8222787546 587197.1696081084 1.0 1.8406170504293446 1.004956229523335 19.15635282184246 -10.235333936798664 3.6725328574438847 0.9993876511768852 1.4227866385644894 0.2544480182738066 0.3411571036004002 52925913.73832747 92244036.39342062 397161.05028530414 0.1346557201564219 5.8165580022594185e-11 10.235333936798664 0.4233989873876042 ESIGNVQVLLEYHIAYLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESIGNVQVLLEYHIAYLK 18 0 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 0 35853900.0 7651900.0 10330000.0 17872000.0 False True 11608491.728822501 8486530.791341616 14339591.366424125 1.0 0.7310623110727271 1.2352673974708213 23.4686772017292 -6.76179952535723 1.6055746831019813 0.8441343411442579 1.2372822973201318 0.6982951567996311 0.11314758332300585 0.27991600644391995 1.4225494557030656 0.05559054079111645 0.13336303195517438 1.73061504393937e-07 6.76179952535723 0.39314795617587395 ESIGNVQVLLEYHIAYLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESIGNVQVLLEYHIAYLK 18 0 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 0 21881200.0 7651900.0 4955700.0 9273600.0 False True 9905535.39149886 4679910.938589594 7585899.955171396 1.0 0.47245411314223285 0.7658243250215204 23.23980352382165 -10.143481828176377 5.468239496122308 1.0000078907767678 0.6191392190817968 0.6920411420168686 0.119767887473036 1.1521697205392917e-05 1.8047986615107793e-06 0.11596715919227947 0.03865491946608318 7.18651227678345e-11 10.143481828176377 -0.38086867169497096 ESIK(ub)LVSIDSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESIKLVSIDSK 11 1 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98;O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;O75369-5;O75369-4 P21333-2;O75369-2 FLNA;FLNB Filamin-A;Filamin-B 1 5649900.0 1640200.0 1511100.0 2498600.0 True False 1588132.7488000893 2114490.1102823983 1844141.703606725 1.0 1.33143158963254 1.1612012314462143 20.59890007880198 -10.133236554947617 4.581362421934443 0.9999736649779526 1.2463164105443476 0.736258299641669 0.0694962527315749 1.8695588569453045e-05 3.537145431194313e-06 0.06729664609380002 0.022429819118711433 7.358062035906799e-11 10.133236554947617 0.24634274556639502 ESIK(ub)LVSIDSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESIKLVSIDSK 11 1 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98;O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;O75369-5;O75369-4 P21333-2;O75369-2 FLNA;FLNB Filamin-A;Filamin-B 1 19497300.0 2875000.0 7429600.0 9192700.0 True False 4361585.190653915 6103729.83227025 7375758.815696452 1.0 1.3994292362669964 1.691072968493511 22.056421138054983 -6.974554693465954 0.10162070592555275 0.2984023046753126 2.7995044124023187 0.9999997269648325 0.000147904241590187 0.07485056079576549 0.0029861848403376435 0.0257625107829505 0.047251582493856775 1.0603403945544932e-07 6.974554693465954 2.5011021077270064 ESIK(ub)LVSIDSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESIKLVSIDSK 11 1 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98;O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;O75369-5;O75369-4 P21333-2;O75369-2 FLNA;FLNB Filamin-A;Filamin-B 1 5700800.0 1640200.0 2323300.0 1737300.0 True False 1363898.9731802123 2310783.9217610583 2100561.3976323805 1.0 1.6942485970005448 1.5401150957203873 20.379305354236255 -10.101710239709714 4.663576106411406 0.999960094203569 1.6171818463641574 0.9553136333676715 0.06292473844063401 2.6117952618547892e-05 5.031027607007111e-06 0.060930544840054675 0.020308871998125415 7.912063430071463e-11 10.101710239709714 0.6172217521605884 ESIK(ub)LVSIDSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESIKLVSIDSK 11 1 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98;O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;O75369-5;O75369-4 P21333-2;O75369-2 FLNA;FLNB Filamin-A;Filamin-B 1 16112000.0 2875000.0 5107000.0 8130000.0 True False 3721744.1747225164 4822790.9605862 6650423.420844493 1.0 1.2958416092491833 1.7869104131372306 21.827547460147432 -6.963519287700717 0.3826148132290636 0.9672444670481215 2.132945321310243 0.9998792934705076 0.003565533739989602 0.0784670875585371 0.01665422892728963 0.0063746427954588306 0.041443676345908675 1.0876288332519709e-07 6.963519287700717 1.1657008542621217 ESILADK(ub)SLATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESILADKSLATR 12 1 B1AJY7;O75832;B1AJY5;O75832-2;B1AJY6 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 1 16707600.0 8530600.0 3936300.0 4240700.0 True False 11183699.210447913 3349019.3835772253 3801913.043666796 1.0 0.29945542351930754 0.33995129626832365 23.41489412876511 -10.015273545014002 6.033700342952463 1.0000007783124492 0.3197033598937617 0.9973494649624868 0.0165323708208203 1.7307495045794395e-07 2.8265988398570327e-08 0.016007417341784035 0.005335799738502021 9.654425931222476e-11 10.015273545014002 -0.6802974184186874 ESILADK(ub)SLATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESILADKSLATR 12 1 B1AJY7;O75832;B1AJY5;O75832-2;B1AJY6 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 1 38560600.0 17197400.0 15547600.0 5815600.0 True False 16651477.950380838 21755837.75966293 4292319.895739719 1.0 1.306540946364785 0.2577741092130233 23.98914689778772 -6.828451416439638 1.3347077560849843 1.1639776009575122 0.23040887778029895 0.9027766102287976 0.13728853647849884 0.18271733746674362 0.6371217662171669 0.08077331950925667 0.18590770664431674 1.4843919264089923e-07 6.828451416439638 -0.9335687231772133 down ESILADK(ub)SLATR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESILADKSLATR 12 1 B1AJY7;O75832;B1AJY5;O75832-2;B1AJY6 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 1 63857000.0 27398000.0 19487000.0 16972000.0 True False 41564769.062099524 16009392.597374048 13617476.760908151 1.0 0.38516736550262887 0.32762065249449757 25.308857860020293 -13.999999999999998 0.33509631274978874 7.902233934887102 0.31802733061617755 0.9997253200277313 0.005043420305743988 19.262965762645724 0.1853949824000491 93.94997223997069 0.0180973588054799 1.0000000000000041e-14 13.999999999999998 -7.584206604270924 ESILADK(ub)SLATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESILADKSLATR 12 1 B1AJY7;O75832;B1AJY5;O75832-2;B1AJY6 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 1 17779500.0 8530600.0 5773700.0 3475200.0 True False 11684593.350796858 5518598.84292732 2654429.333990636 1.0 0.472297039122116 0.2271734457758952 23.478104190288 -9.858325879648575 0.19658865298364592 1.595737048648436 1.4037040897494824e-10 0.9994631321108344 0.007471499402317847 1.3339215318046624 0.0865673088262941 0.5815313292697538 0.14662856896795495 1.385715645281103e-10 9.858325879648575 -1.5957370485080655 ESILADK(ub)SLATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESILADKSLATR 12 1 B1AJY7;O75832;B1AJY5;O75832-2;B1AJY6 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 1 39601100.0 17197400.0 19128600.0 3275100.0 True False 14300400.073996695 19025550.435070176 3959908.2676485404 1.0 1.3304208509288853 0.276908914936519 23.769552173221996 -6.82241519500596 1.3614504824601907 1.1776713287349443 0.25270684109814096 0.8898369682022654 0.1460197304601683 0.1903610523324555 0.6926581942465849 0.08426898877949049 0.19410702689710635 1.5051674052234185e-07 6.82241519500596 -0.9249644876368033 down ESILADK(ub)SLATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESILADKSLATR 12 1 B1AJY7;O75832;B1AJY5;O75832-2;B1AJY6 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 1 67129000.0 27398000.0 21859000.0 17872000.0 True False 35467251.09532092 20642527.434394684 14619479.382205747 1.0 0.5820165588507643 0.41219657376081364 25.079984182112742 -13.999999999991095 0.12397005687187285 2.987782862852374 0.15510455262889017 0.9996737051419113 0.004461635964021917 11.950280175168983 0.10885176052760293 5.823855139624991 0.2282546093884089 1.0000000000205042e-14 13.999999999991095 -2.832678310223484 ESILDLSK(ub)YIDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESILDLSKYIDK 12 1 Q9UK45;K7ENY5;K7EML7 Q9UK45 LSM7 U6 snRNA-associated Sm-like protein LSm7 1 40391200.0 10961100.0 22288000.0 7142100.0 True False 14370108.247443382 18962717.27794355 6403104.003860833 1.0 1.3195946023104768 0.4455849527090392 23.776567593610235 -6.807748722092584 1.4240008333894065 1.174646208238377 0.431073374974246 0.8538572406693785 0.1380359533440694 0.2098898075125848 0.839257235840796 0.07623034986189771 0.17652111225272588 1.556866156328024e-07 6.807748722092584 -0.743572833264131 down ESILDLSK(ub)YIDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESILDLSKYIDK 12 1 Q9UK45;K7ENY5;K7EML7 Q9UK45 LSM7 U6 snRNA-associated Sm-like protein LSm7 1 73871300.0 21848000.0 41099000.0 10924300.0 True False 21154447.198990557 57510045.02845358 8062898.108024873 1.0 2.718579430957564 0.3811443538174619 24.334457650369277 -6.709712023999395 1.7966476319208096 2.056875994727275 0.3867751861138263 0.4635723158268059 0.7242327304175283 0.375639038174961 2.36355702166814 0.3208372775842336 0.8152352630495362 1.9511379494995389e-07 6.709712023999395 -1.6701008086134488 ESILDLSK(ub)YIDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESILDLSKYIDK 12 1 Q9UK45;K7ENY5;K7EML7 Q9UK45 LSM7 U6 snRNA-associated Sm-like protein LSm7 1 56782100.0 19533400.0 15230700.0 22018000.0 True False 29633595.882824074 12512662.58699774 17666132.64916779 1.0 0.4222458400416469 0.5961521753560545 24.820730364677157 -10.347749841935059 5.000704463846695 1.0002686551406683 0.5091990076987485 0.9139404432718635 0.07099696409330668 0.00021276556363802334 2.7751261637324764e-05 0.06877947512444967 0.022914171630336405 4.490039463273644e-11 10.347749841935059 -0.49106964744191983 ESILDLSK(ub)YIDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESILDLSKYIDK 12 1 Q9UK45;K7ENY5;K7EML7 Q9UK45 LSM7 U6 snRNA-associated Sm-like protein LSm7 1 29216400.0 10961100.0 14774200.0 3481100.0 True False 15013714.882589657 14121426.992253993 2658935.87550495 1.0 0.9405684803985197 0.17710046422876524 23.839777655133126 -6.922435122118205 0.806466863674719 1.0154135334588 0.04681674703762469 0.9948308402202612 0.02693952546502346 0.09676039362760219 0.09834680472011861 0.023515519561873994 0.07216627959430225 1.195542110596423e-07 6.922435122118205 -0.9685967864211752 down ESILDLSK(ub)YIDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESILDLSKYIDK 12 1 Q9UK45;K7ENY5;K7EML7 Q9UK45 LSM7 U6 snRNA-associated Sm-like protein LSm7 1 60395800.0 21848000.0 31522000.0 7025800.0 True False 18167580.030509237 31352184.729372863 8494862.296371136 1.0 1.7257215697810282 0.4675835902253089 24.114862925803553 -6.750284298621781 1.6487123161522117 1.4265805652119905 0.4650146231871762 0.6502408645730016 0.3049574051922118 0.29954203760006765 1.602072716565849 0.14610864436673818 0.3546176341536195 1.7771156905662923e-07 6.750284298621781 -0.9615659420248144 ESILDLSK(ub)YIDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESILDLSKYIDK 12 1 Q9UK45;K7ENY5;K7EML7 Q9UK45 LSM7 U6 snRNA-associated Sm-like protein LSm7 1 53982300.0 19533400.0 20079800.0 14369100.0 True False 25286371.360878203 18962341.47843721 11754071.239416555 1.0 0.7499036223036252 0.4648381957089288 24.591856686769606 -6.969418847890023 0.2717071443684199 1.0694146541509133 0.13673761471221063 0.9999774881121694 0.0010373314552355913 0.07649172124256728 0.00970294935157678 0.005530116516593708 0.026450905647634138 1.072954120924157e-07 6.969418847890023 -0.9326770394387027 down ESIMK(ub)EFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESIMKEFR 8 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 13858300.0 3494400.0 6307400.0 4056500.0 True False 4581192.2398177385 5366360.506052629 3636772.2926956355 1.0 1.1713895041143543 0.7938484355854762 22.12729167302545 -6.783273554984706 1.5229203927669037 1.0966349132942443 0.7905354276271456 0.7788339485206843 0.07258729023983562 0.2455389839552951 1.1249619273719769 0.03753111325356166 0.08832578238669299 1.647124567904042e-07 6.783273554984706 -0.30609948566709877 ESIMK(ub)EFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESIMKEFR 8 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 39522900.0 7720100.0 8322800.0 23480000.0 True False 11711956.11491036 6837531.313666805 18839167.7083504 1.0 0.5838077983371215 1.6085415214599779 23.48147871712989 -6.796434401423336 1.4703239461021174 0.7693200192588114 1.6214889063492461 0.8215615521104077 0.17775223413822033 0.225887255400857 0.9644048175054573 0.09512142915912536 0.22172513143591824 1.5979588766143053e-07 6.796434401423336 0.8521688870904347 ESIMK(ub)EFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESIMKEFR 8 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 15790600.0 3494400.0 5981500.0 6314700.0 True False 4786374.11260926 5717217.55182462 4823297.915328806 1.0 1.1944777857550122 1.0077143578522778 22.19050173454834 -10.912451257847591 2.6516058126653705 0.9407641761011535 1.1010960716908627 0.2809284295400818 0.07624585140244713 54158183.32077561 32692478.55443757 19975630.44548016 0.030024570287734413 1.2233444109018809e-11 10.912451257847591 0.16033189558970917 ESIMK(ub)EFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESIMKEFR 8 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 56747100.0 7720100.0 11486000.0 37541000.0 True False 9993821.635921841 10846794.002994541 30708923.203188535 1.0 1.08534996902554 3.072790802350147 23.25260503922234 -6.915910861317735 0.8544950435446692 0.9493598884046517 3.3649737461315485 0.9929677900409473 0.08030602699485861 0.10063809083600998 0.11852025867632 0.06773328236247103 0.1956002714143727 1.2136379233598638e-07 6.915910861317735 2.415613857726897 up ESIVATTK(ub)SK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESIVATTKSK 10 1 Q6P0N0;G5E9K5;Q6P0N0-2;H7C1S6 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 4019400.0 1263300.0 1716100.0 1040000.0 True False 1656198.5338146007 1460064.5693054057 932390.776384434 1.0 0.8815758132224317 0.562970415290084 20.659444192995846 -6.953870735767605 0.5146008481451124 1.0056488168163116 0.4248096643669835 0.9994710648612822 0.004244387390723756 0.0819677296459585 0.029810790754362704 0.004850756812821779 0.026304198803878145 1.1120626744685829e-07 6.953870735767605 -0.5808391524493282 ESIVATTK(ub)SK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESIVATTKSK 10 1 Q6P0N0;G5E9K5;Q6P0N0-2;H7C1S6 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 3791650.0 1129600.0 1790000.0 872050.0 True False 1093741.4663117782 2504756.3347266833 643633.9440607715 1.0 2.2900808023426316 0.5884699116612805 20.06084032998781 -6.703970497662733 1.8164409365800385 1.7979697091498967 0.5931025637281403 0.436437263639329 0.5441782755944891 0.38738664938302286 2.487529488392477 0.2387416284873131 0.6110503771091484 1.9771039434673676e-07 6.703970497662733 -1.2048671454217565 ESIVATTK(ub)SK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESIVATTKSK 10 1 Q6P0N0;G5E9K5;Q6P0N0-2;H7C1S6 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 3290200.0 1263300.0 1009600.0 1017300.0 True False 1730376.1493988293 964992.5336992625 777034.691951161 1.0 0.5576778979729478 0.4490553641883702 20.722654254518737 -13.999999999925983 0.1972128597619687 3.4332023818496644 0.3765415610095786 0.9994870295143474 0.0053967202271887295 12.47714975645265 0.14082214987699987 11.69736816898962 0.07063052516839027 1.000000000170431e-14 13.999999999925983 -3.0566608208400856 ESIVATTK(ub)SK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESIVATTKSK 10 1 Q6P0N0;G5E9K5;Q6P0N0-2;H7C1S6 Q6P0N0 MIS18BP1 Mis18-binding protein 1 1 3732260.0 1129600.0 2143900.0 458760.0 True False 939312.4497648859 2132350.385169167 554684.5949334202 1.0 2.270118303768787 0.5905219238521326 19.841245605422085 -6.704528885143997 1.815590975771859 1.785201560679918 0.5952084095341985 0.43875442830272626 0.5357036312800583 0.3861417021088237 2.4778460362750905 0.2351629772569949 0.6012237330332195 1.974563545829231e-07 6.704528885143997 -1.1899931511457196 ESIVDVEGVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESIVDVEGVVR 11 0 P14868;P14868-2;C9J7S3;C9JLC1;H7C278;C9JQM9 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 8286300.0 1539300.0 2933700.0 3813300.0 False True 2018037.206602406 2496003.395473032 3418736.295756503 1.0 1.2368470647155887 1.6940898238007873 20.94452134301817 -6.960730207277018 0.4250168780874248 0.9808479434458116 1.9674800597563815 0.9997963309280927 0.004111310475545235 0.07944128877796192 0.02017504240635494 0.00593621548613801 0.03801131626602888 1.0946361657449479e-07 6.960730207277018 0.9866321163105699 ESIVDVEGVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESIVDVEGVVR 11 0 P14868;P14868-2;C9J7S3;C9JLC1;H7C278;C9JQM9 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 5954400.0 1539300.0 2343700.0 2071400.0 False True 2108420.8080183826 2240147.584420526 1582177.9818221137 1.0 1.062476511283318 0.7504090150339283 21.00773140454106 -6.854638935439616 1.2124641197132007 1.0335231289122997 0.7367689563525505 0.9467937400542287 0.031097965065862623 0.15242480758185176 0.42886657514701176 0.02004329158604368 0.046541444836611226 1.3975297591169858e-07 6.854638935439616 -0.29675417255974923 ESK(ub)DPADETEAD ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESKDPADETEAD 12 1 P16949 P16949 STMN1 Stathmin 1 8433800.0 3208800.0 3822800.0 1402200.0 True False 4206767.874063401 3252453.1411576928 1257113.7948521671 1.0 0.7731477558366167 0.2988312720088109 22.004280782920105 -6.959166786339988 0.44702441437466106 1.0157695598376628 0.03749928531182092 0.999738029365828 0.004728318539384563 0.08000015341329536 0.022241533225122432 0.006312355072716543 0.03925181874829911 1.0985838585493981e-07 6.959166786339988 -0.9782702745258419 down ESK(ub)DPADETEAD ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESKDPADETEAD 12 1 P16949 P16949 STMN1 Stathmin 1 10769900.0 5034900.0 3900500.0 1834500.0 True False 4875069.855464919 5457989.990838795 1353989.4161796751 1.0 1.1195716477211968 0.2777374389131804 22.216991460886067 -6.870909416866054 1.1293287077657612 1.0680063779341702 0.22758761130561514 0.9655796525335999 0.06899366120698346 0.13598301286947997 0.3235935577703666 0.04738760894351546 0.11236809789795955 1.346141096659493e-07 6.870909416866054 -0.8404187666285551 down ESK(ub)DPADETEAD ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESKDPADETEAD 12 1 P16949 P16949 STMN1 Stathmin 1 8463000.0 3208800.0 3588600.0 1665600.0 True False 4395180.07455946 3430043.786086739 1272219.584108771 1.0 0.7804102967113448 0.28945789763489693 22.067490844442997 -6.957808392510995 0.46529416990520034 1.0135783769620017 0.036321925677188276 0.9996800766903654 0.005313070575860245 0.08049351537421909 0.02409593874244168 0.006729730202341654 0.04053630756623251 1.1020254076995482e-07 6.957808392510995 -0.9772564512848134 down ESK(ub)DPADETEAD ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESKDPADETEAD 12 1 P16949 P16949 STMN1 Stathmin 1 11379430.0 5034900.0 5415400.0 929130.0 True False 4186742.433889186 5386226.165327267 1123406.787188267 1.0 1.286495706477899 0.26832479067614917 21.997396736320344 -6.831571300083253 1.3208983998304344 1.1529236584961313 0.24004081896096985 0.9089783345490295 0.12933976546469853 0.17887878590170767 0.6098387901286472 0.07686920924843613 0.17689162319855006 1.473766566209178e-07 6.831571300083253 -0.9128828395351615 down ESK(ub)EHVIANSGQFHCQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESKEHVIANSGQFHCQR 17 1 P55160;P55160-2;F8W050 P55160 NCKAP1L Nck-associated protein 1-like 1 29978000.0 3239100.0 6567900.0 20171000.0 True False 4913951.509929422 5395806.929763073 16184193.008736635 1.0 1.0980586436109483 3.2935190703518122 22.22845219081556 -6.916249650317152 0.8520712595347433 0.9447074727251373 3.6187280121913767 0.993074290229035 0.08811587150473515 0.100429125889953 0.11741789776794072 0.07444989010375733 0.21561018495962944 1.212691545124069e-07 6.916249650317152 2.6740205394662393 up ESK(ub)FFEHFIEGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESKFFEHFIEGGR 13 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8;F5H3F0;Q96FW1-2 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 5314400.0 1446600.0 1828000.0 2039800.0 True False 1896506.6088943265 1555269.5254881897 1828741.0631432394 1.0 0.8200707122212034 0.9642682258879157 20.85491296842928 -9.968232275594838 5.198176534643905 1.0000004671226834 0.8921694690727444 0.4271315096556334 0.058868388446159735 3.1867288408331354e-07 6.331583486678144e-08 0.05699931875241746 0.018999690672131805 1.0758896370197787e-10 9.968232275594838 -0.10783099804993901 ESK(ub)FFEHFIEGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESKFFEHFIEGGR 13 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8;F5H3F0;Q96FW1-2 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 8078100.0 1997900.0 1610300.0 4469900.0 True False 1934477.7580951713 2253301.187603565 3299099.0958743715 1.0 1.1648111115127684 1.7054210533404666 20.883512710630367 -6.9494278865285395 0.5650880523954093 0.9931089221409818 1.9031866042000811 0.9991556299126245 0.008755216893673746 0.08371625863555367 0.03691917835947428 0.009328446908508238 0.04499070852459577 1.1234975080318368e-07 6.9494278865285395 0.9100776820590993 ESK(ub)FFEHFIEGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESKFFEHFIEGGR 13 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8;F5H3F0;Q96FW1-2 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 10917800.0 1997900.0 2393000.0 6526900.0 True False 1661342.371977044 2380108.434026691 7891644.613024107 1.0 1.432641744515488 4.750161523679691 20.663917986064643 -6.930893483715281 0.7394218864841599 0.9511861790621686 5.4469897937386005 0.9967109442465729 0.09607353349785377 0.09217653835922196 0.07542691360137742 0.0879973973296624 0.2987171046755859 1.172482896735509e-07 6.930893483715281 4.495803614676432 up ESKDPADETEAD ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESKDPADETEAD 12 1 P16949 P16949 STMN1 Stathmin 0 18662700.0 6696200.0 1900500.0 10066000.0 False True 6483632.796314561 2659379.5609765714 7429412.626472943 1.0 0.4101681332860524 1.1458718992685681 22.628370954760538 -6.693261783839533 1.8550937651853547 0.6313460062387949 1.1434160522858925 0.3856478440627835 0.2492947707743176 0.40967582961428645 2.735977808365665 0.10741202211455553 0.27853622263471767 2.026460842108982e-07 6.693261783839533 0.5120700460470976 ESKPLTAQQTTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESKPLTAQQTTK 12 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 3167130.0 1400800.0 649730.0 1116600.0 False True 1356332.3707591537 909170.5772971894 824128.9627180294 1.0 0.6703154749512591 0.6076157883460052 20.371279325150187 -13.999999999999998 0.23338721980596686 3.114357573361517 0.5780968085835193 0.9995146014266787 0.003791824257142294 13.39922428175259 0.152942004796765 13.153568116846214 0.03187488378119406 1.0000000000000041e-14 13.999999999999998 -2.536260764777998 ESLEPDAYALFHKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESLEPDAYALFHKK 14 1 H0YKX0;Q96EP0-3;Q96EP0;A0A0B4J293;H0YMG4;Q96EP0-2 H0YKX0 RNF31 E3 ubiquitin-protein ligase RNF31 1 6994500.0 2740200.0 0.0 4254300.0 True False 2278597.711442758 0.0 5143854.460339286 1.0 0.0 2.2574649463166145 21.119714807250414 -6.786279905678893 1.5110714215194325 0.4383794152881084 2.2791060384790516 0.7890717375259892 0.42418202151032874 0.24094334599471898 1.0868637668698116 0.2210019714006052 0.5188768570078426 1.635761922189903e-07 6.786279905678893 1.8407266231909432 ESLK(ub)ELEEEAEEEQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESLKELEEEAEEEQR 15 1 Q9H2J4 Q9H2J4 PDCL3 Phosducin-like protein 3 1 6103900.0 2249200.0 2348600.0 1506100.0 True False 3080790.0223445324 2244831.0862183915 1150390.199103159 1.0 0.7286543613608687 0.37340753208090854 21.55486892516929 -6.967419288980887 0.313767994116812 1.0523496727152295 0.038358001668057355 0.9999546827413828 0.0017271610865924197 0.0771492998099893 0.012013211110199696 0.005527624282172282 0.031426119894189836 1.0779055573501589e-07 6.967419288980887 -1.0139916710471721 down ESLK(ub)EYQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESLKEYQK 8 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 18205500.0 5837800.0 7170700.0 5197000.0 True False 7653412.333335613 6100859.511169681 4659264.293144134 1.0 0.797142404649551 0.6087826044403739 22.86767169735807 -6.972016812629615 0.20436226947515249 1.1059952153330705 0.29470443253274775 0.9999941314979299 0.00038695210028711214 0.07565360491154546 0.00663440354112406 0.005901418735510788 0.01978144721402117 1.0665548314161225e-07 6.972016812629615 -0.8112907828003229 ESLK(ub)EYQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESLKEYQK 8 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 22729700.0 9264400.0 7640900.0 5824400.0 True False 8970306.693076165 10691951.216767104 4298814.911745375 1.0 1.1919270525075591 0.47922719465806723 23.096725880780426 -6.835017914793197 1.305377783229236 1.1022522768180585 0.4580118974653546 0.9155344818642208 0.08751018423131525 0.17470053590055787 0.5804132727460453 0.05260654489817488 0.1210779165193361 1.462116860401327e-07 6.835017914793197 -0.6442403793527038 down ESLK(ub)EYQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESLKEYQK 8 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 16635200.0 4825600.0 3451700.0 8357900.0 True False 7320787.998615501 2835717.1667448077 6705957.4016022915 1.0 0.38735135716006186 0.916015789949185 22.803567515717187 -10.331495841360752 8.311635117869102 1.0000009674116546 0.6516835735546336 0.3666064484459952 0.21582635091520733 3.869126779440453e-06 3.1133445028134206e-07 0.2089735448136737 0.06965765523060964 4.661268914348459e-11 10.331495841360752 -0.348317393857021 ESLK(ub)EYQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESLKEYQK 8 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 15085400.0 5837800.0 5663000.0 3584600.0 True False 7996192.420613069 5412789.934963277 2737991.3071543598 1.0 0.6769209206384103 0.34241188344795204 22.93088175888096 -7.219934655243781 0.2737152388733152 1.0920363328929132 3.941161480254271e-15 0.9999420896477813 0.002043038578747121 0.09316848039087218 0.014994042548446617 0.011287734418115697 0.04102539989364324 6.026502551323346e-08 7.219934655243781 -1.0920363328929092 down ESLK(ub)EYQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESLKEYQK 8 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 25328700.0 9264400.0 11452000.0 4612300.0 True False 7703759.082508684 11390305.802955978 5576710.605134305 1.0 1.478538682345034 0.7238947305343668 22.877131156214702 -6.735368960617707 1.7038082200448328 1.2862470149076304 0.7238972441131608 0.5839199197496765 0.20109531614363133 0.3262549638130452 1.8577868186943896 0.09344551147068218 0.2304690192351753 1.8392088133909184e-07 6.735368960617707 -0.5623497707944696 ESLK(ub)EYQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESLKEYQK 8 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 10356600.0 4825600.0 2709500.0 2821500.0 True False 6246834.326796872 2558713.943158077 2308015.951034774 1.0 0.4096016973240403 0.36946969141380015 22.574693837809637 -13.999999999999998 0.38192734893923813 9.867276751801144 0.36606217054005286 0.9998106075646607 0.00396677510744623 24.28026043971506 0.2017325801332801 177.16192288096988 0.010814884427003464 1.0000000000000041e-14 13.999999999999998 -9.501214581261092 ESLLLSEQK(ub)TSLP ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESLLLSEQKTSLP 13 1 Q9NPF0;Q9NPF0-2 Q9NPF0 CD320 CD320 antigen 1 92405000.0 30356000.0 40596000.0 21453000.0 True False 39797009.967922196 34539235.04196861 19233249.351706997 1.0 0.8678851770474328 0.4832837785353643 25.246156706375046 -6.952125214139575 0.5350084918602076 1.0058558246178648 0.327703569372711 0.9993576541663989 0.005555073978234817 0.08264352091887078 0.032516840298218976 0.006152719256089842 0.031826270539012505 1.1165412844163717e-07 6.952125214139575 -0.6781522552451538 down ESLLLSEQK(ub)TSLP ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESLLLSEQKTSLP 13 1 Q9NPF0;Q9NPF0-2 Q9NPF0 CD320 CD320 antigen 1 116500000.0 42085000.0 42365000.0 32050000.0 True False 40749034.711164325 59281565.43055636 23655143.520609763 1.0 1.4547968031820526 0.5805080706397392 25.280262548489958 -6.765341840856436 1.5923863181123532 1.262406544375545 0.5764434811319833 0.712405808643125 0.1914640799639341 0.2740206590489733 1.370523617233149 0.09481843409882389 0.2266761218652542 1.7165567231565282e-07 6.765341840856436 -0.6859630632435617 ESLLLSEQK(ub)TSLP ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESLLLSEQKTSLP 13 1 Q9NPF0;Q9NPF0-2 Q9NPF0 CD320 CD320 antigen 1 201790000.0 83845000.0 64535000.0 53410000.0 True False 127198994.89056614 53018225.03574357 42853490.08956537 1.0 0.4168132388259597 0.3369011691203516 26.92251202978308 -13.999999999999964 0.2800581115855597 5.754434593861476 0.31285793979804993 0.9996053062412416 0.005871826236824077 15.401408630698345 0.1676422394145212 41.941496206665285 0.03160239864794404 1.0000000000000819e-14 13.999999999999964 -5.441576654063426 ESLLLSEQK(ub)TSLP ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESLLLSEQKTSLP 13 1 Q9NPF0;Q9NPF0-2 Q9NPF0 CD320 CD320 antigen 1 83419000.0 30356000.0 29767000.0 23296000.0 True False 41579433.54005459 28451795.51369445 17793964.596180312 1.0 0.6842756885152383 0.42795110662195307 25.309366767897938 -7.3798587192272675 0.1874979941514496 1.2093473048073393 1.0436123166165627e-11 0.99997653836732 0.0011332090595051578 0.11810109769133778 0.013647469676124688 0.02524938070353134 0.054658608681513135 4.170050177273121e-08 7.3798587192272675 -1.2093473047969032 down ESLLLSEQK(ub)TSLP ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESLLLSEQKTSLP 13 1 Q9NPF0;Q9NPF0-2 Q9NPF0 CD320 CD320 antigen 1 105344000.0 42085000.0 42188000.0 21071000.0 True False 34995542.18161762 41960724.87033766 25476848.678703696 1.0 1.1990305694528915 0.728002685213036 25.060667823924234 -6.79188213267748 1.488596524994891 1.1109639653907666 0.7227143792886027 0.8074492536002464 0.08471760009892038 0.23254305081673943 1.017901043354049 0.04478921096770977 0.10473001792615069 1.614796752456215e-07 6.79188213267748 -0.38824958610216387 ESLLLSEQK(ub)TSLP ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESLLLSEQKTSLP 13 1 Q9NPF0;Q9NPF0-2 Q9NPF0 CD320 CD320 antigen 1 222074000.0 83845000.0 72403000.0 65826000.0 True False 108539005.3320381 68373709.40264793 53846343.431797 1.0 0.6299459737398723 0.4961013164536791 26.693638351875528 -13.999999999999998 0.1415077173847554 2.7701812777806256 0.33343213164898894 0.9995969913319933 0.004278328480281423 11.93585078063745 0.11796714147436943 5.829480140570655 0.14557662705716837 1.0000000000000041e-14 13.999999999999998 -2.436749146131637 ESLQQMAEVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESLQQMAEVTR 11 0 K7ELL7;P14314-2;P14314;K7EPW7;K7EKX1;K7EJ70 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 29919800.0 3903800.0 14863000.0 11153000.0 False True 5117919.604452973 12645498.335520219 9998994.547130376 1.0 2.4708278583582457 1.9537224731765037 22.287126054105208 -9.919953085626743 6.037012019935799 0.9999999716291024 2.212275165687095 0.8799225599598008 0.21110738949146332 1.0396491256575e-06 1.8617175048900186e-07 0.20440391489735404 0.06813461697994705 1.2023943154502908e-10 9.919953085626743 1.2122751940579928 ESLQQMAEVTR ddPTM_RPMI8226_Bortezomib_2h_R1 2 ESLQQMAEVTR 11 0 K7ELL7;P14314-2;P14314;K7EPW7;K7EKX1;K7EJ70 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 27238390.0 9262290.0 2418000.0 15558100.0 False True 8968263.673871214 3383520.0097034206 11482966.877004627 1.0 0.3772770441129214 1.2804002307001667 23.096397264438334 -6.721161029436276 1.7552014929880453 0.6216317422372684 1.2790859693845138 0.5180986887218981 0.2620043665412083 0.35299727850028967 2.125942654197393 0.11849913413860548 0.29706451619898283 1.9003735212180173e-07 6.721161029436276 0.6574542271472454 ESLQQMAEVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESLQQMAEVTR 11 0 K7ELL7;P14314-2;P14314;K7EPW7;K7EKX1;K7EJ70 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 25894700.0 3903800.0 8328900.0 13662000.0 False True 5347140.356228255 7960901.65801088 10435316.977722183 1.0 1.4888147921417778 1.9515696769708522 22.3503361156281 -6.971788934828534 0.21113244207526918 0.7611939258872149 2.69212535050821 0.9999931769813085 0.001014846836174291 0.07572639813296236 0.006913386286533289 0.013733591255923449 0.0478277962127328 1.0671146081450779e-07 6.971788934828534 1.930931424620995 ESLQQMAEVTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESLQQMAEVTR 11 0 K7ELL7;P14314-2;P14314;K7EPW7;K7EKX1;K7EJ70 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 11957800.0 7024900.0 3094800.0 1838100.0 False True 5841515.605836883 3078127.6981302975 2222438.2115858416 1.0 0.5269399083783344 0.38045575181981295 22.477911300303536 -13.999999999999998 0.16416216124477215 3.351414840432938 0.2428688415676914 0.9995260448030243 0.005755719286755625 12.040048103014447 0.12816807374769543 9.013029854752759 0.12608636952630722 1.0000000000000041e-14 13.999999999999998 -3.108545998865247 ESLVYFLIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESLVYFLIGK 10 0 G5EA36;P30260;P30260-2;I3L394 G5EA36 CDC27 Cell division cycle protein 27 homolog 0 1544870.0 430120.0 620130.0 494620.0 False True 563891.4852880056 527609.0212478079 443441.46713006636 1.0 0.9356570102815677 0.7863950400023867 19.105058032983923 -6.957044167063587 0.4752622439284253 1.003747411341896 0.7121310978389476 0.9996443760765406 0.0016872418281405474 0.08077438994914458 0.025164559203365626 0.002084750682226764 0.012315401577788461 1.1039663425577376e-07 6.957044167063587 -0.2916163135029485 ESLVYFLIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESLVYFLIGK 10 0 G5EA36;P30260;P30260-2;I3L394 G5EA36 CDC27 Cell division cycle protein 27 homolog 0 3218320.0 430120.0 1350900.0 1437300.0 False True 589146.9875559454 1291212.7711710897 1097839.3421226821 1.0 2.191664895933082 1.8634387772685188 19.168268094506814 -10.458393024774862 4.898125869216959 0.9977146927180418 2.0275518366009107 0.9289152939004048 0.13399775183077905 0.003349243847743204 0.0003703399420274572 0.12994397221530518 0.04324758843909896 3.480222217722208e-11 10.458393024774862 1.0298371438828688 ESLWPFLIDK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESLWPFLIDKR 11 1 Q9NZL9;Q9NZL9-2;Q9NZL9-4 Q9NZL9 MAT2B Methionine adenosyltransferase 2 subunit beta 1 13611200.0 6139900.0 4064200.0 3407100.0 True False 5944992.235311348 5687056.2545230165 2514678.299190934 1.0 0.9566128986247829 0.4229910149006673 22.503243495008288 -6.923041673306211 0.8018451062530243 1.0105338852081267 0.3306169376181764 0.9949849481572889 0.018580742883642767 0.09641507854852242 0.09658168770540805 0.01627268611287329 0.05025680859054876 1.1938735392400552e-07 6.923041673306211 -0.6799169475899502 down ESLWPFLIDK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESLWPFLIDKR 11 1 Q9NZL9;Q9NZL9-2;Q9NZL9-4 Q9NZL9 MAT2B Methionine adenosyltransferase 2 subunit beta 1 12474900.0 6139900.0 4629100.0 1705900.0 True False 5105598.8936893 4604162.119495594 2062595.802809576 1.0 0.9017868844312271 0.4039870435883667 22.283648770442564 -6.939502166049641 0.6641820478595443 1.005638399813789 0.27169110725067197 0.9980979186633756 0.011379174874400886 0.0879945778280826 0.05565015435945749 0.011035401080624075 0.04293950410076892 1.149470510405719e-07 6.939502166049641 -0.733947292563117 down ESMLVEWEQVK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESMLVEWEQVKQR 13 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BRI8;H3BM93;H3BNN5;H3BMX0;H3BP95;H3BNG7 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 21223400.0 3946600.0 6142800.0 11134000.0 True False 3821317.343259623 8595652.07427882 8217671.387159708 1.0 2.24939498663742 2.1504812735992114 21.865638641344656 -10.116703815699957 4.840210855575475 0.9999363469771598 2.1999381301263936 0.99492952212398 0.04038135427913103 2.7738880424637246e-05 5.062020048407712e-06 0.03910113147612813 0.013033026047734491 7.643568892772311e-11 10.116703815699957 1.2000017831492338 ESMLVEWEQVK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESMLVEWEQVKQR 13 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BRI8;H3BM93;H3BNN5;H3BMX0;H3BP95;H3BNG7 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 37451100.0 7830100.0 13626000.0 15995000.0 True False 11878834.15698756 11194333.83957608 12833581.23914245 1.0 0.9423764732830424 1.0803738034841806 23.50188991462065 -6.793301943819666 1.4832347345305987 0.9679313858772497 1.08197519871734 0.8117935841357313 0.024551084354221205 0.2304744127355724 1.0015846577645018 0.013026587396878878 0.0304251326583701 1.6095262208274882e-07 6.793301943819666 0.11404381284009035 ESMLVEWEQVK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESMLVEWEQVKQR 13 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BRI8;H3BM93;H3BNN5;H3BMX0;H3BP95;H3BNG7 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 23062100.0 3946600.0 7227500.0 11888000.0 True False 3281772.764024526 7188564.022953581 14373725.836098406 1.0 2.1904514845622804 4.3798662703482005 21.646043916778932 -6.961651368054194 0.41150666495813903 0.8939037144852849 5.75786412620244 0.999826611534014 0.01843175987099496 0.07911650394485055 0.018990579698021322 0.02820547855426677 0.18271142309356184 1.0923168470963778e-07 6.961651368054194 4.863960411717155 ESNSLEISLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESNSLEISLIK 11 0 Q96RS6;Q96RS6-2;Q96RS6-3 Q96RS6 NUDCD1 NudC domain-containing protein 1 0 4655500.0 1466800.0 1136300.0 2052400.0 False True 2009115.5987795522 1086094.5087583908 1567665.3905048291 1.0 0.5405833837625593 0.7802763521706345 20.938129144340156 -10.110112102433094 4.98906290184025 1.0000123373735603 0.66042986796541 0.7279656379431881 0.09785424459292058 1.3428805535625153e-05 2.395375706219854e-06 0.09475040510541344 0.031582321638085456 7.760467733958928e-11 10.110112102433094 -0.3395824694081503 ESQISAEIELLPTNDK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESQISAEIELLPTNDKK 17 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2;H7C4C3 E9PFW3 AP2M1 AP-2 complex subunit mu 1 45548500.0 18025000.0 18545000.0 8978500.0 True False 17452806.241386168 25950115.21089738 6626761.500773618 1.0 1.486873506299599 0.37969604481481345 24.05695569061954 -6.787178899039049 1.507650621717205 1.2731140112301194 0.3688280912387144 0.7920390583616983 0.20662421573503256 0.23958033985402075 1.0758558344176306 0.10789465059487241 0.2531296553362263 1.6323793829145277e-07 6.787178899039049 -0.904285919991405 down ESQISAEIELLPTNDK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESQISAEIELLPTNDKK 17 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2;H7C4C3 E9PFW3 AP2M1 AP-2 complex subunit mu 1 41911800.0 18025000.0 17361100.0 6525700.0 True False 14988586.142893132 17267572.30839148 7890193.698572278 1.0 1.1520481080584732 0.5264134737827443 23.837360966053815 -6.84249983617019 1.2708840508576402 1.0808745929475119 0.5048161879458203 0.9286421336419086 0.07116876688073069 0.16590230461180566 0.5194471118195725 0.04389351679279152 0.10119160912441597 1.4371435954929535e-07 6.84249983617019 -0.5760584050016916 ESQISAEIELLPTNDK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESQISAEIELLPTNDKK 17 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2;H7C4C3 E9PFW3 AP2M1 AP-2 complex subunit mu 1 67054500.0 36950500.0 17007000.0 13097000.0 True False 47833150.65324673 16060545.499645485 10713480.386568313 1.0 0.3357618154002021 0.22397605510522905 25.511507485477487 -13.999999999999998 0.2507366524724464 5.636671664892826 0.17934267054948294 0.9995440779798015 0.007313743549744477 14.027312095471183 0.15844906329666456 32.77279667480535 0.051378059254729366 1.0000000000000041e-14 13.999999999999998 -5.457328994343343 ESQK(ub)VELSESR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESQKVELSESR 11 1 P25205;P25205-2;J3KQ69;A0A499FHX9;Q7Z6P5 P25205 MCM3 DNA replication licensing factor MCM3 1 4311510.0 2016410.0 1633700.0 661400.0 True False 2643533.0369422166 1389958.3281127245 592964.6725967928 1.0 0.5257957092605485 0.224307645983754 21.334035925903017 -8.408603296872158 0.2568706507527344 1.2150787493442918 2.5086837015084792e-23 0.9993308120166144 0.008259372963868328 0.1291872042724967 0.06432149081786934 0.11779244027226847 0.1067245474913955 3.90298339069986e-09 8.408603296872158 -1.2150787493442918 down ESQK(ub)VELSESR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESQKVELSESR 11 1 P25205;P25205-2;J3KQ69;A0A499FHX9;Q7Z6P5 P25205 MCM3 DNA replication licensing factor MCM3 1 4522020.0 2016410.0 1605940.0 899670.0 True False 2761931.2684313282 1534984.2606665937 687186.4752852663 1.0 0.5557648295637734 0.24880650838047902 21.397245987425908 -8.18475323125898 0.25488745679266267 1.1907853812263676 9.713566429295425e-24 0.9994709649608168 0.0070928728495619495 0.08850808854596409 0.05457792175640935 0.08752197752639707 0.10183311680061172 6.535017708164764e-09 8.18475323125898 -1.1907853812263676 down ESQK(ub)VELSESR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESQKVELSESR 11 1 P25205;P25205-2;J3KQ69;A0A499FHX9;Q7Z6P5 P25205 MCM3 DNA replication licensing factor MCM3 1 4764160.0 610910.0 3172400.0 980850.0 True False 507998.73290179373 3155309.6515279054 1185941.2000620037 1.0 6.211254964169152 2.3345357443859407 18.954465372933115 -6.570502670018103 2.3045365235958117 4.568735850174721 2.3425960740694403 0.0 2.2693436259534097 0.7282848516185101 7.261559580347089 0.8319009792941625 2.543464448662196 2.6884213147503955e-07 6.570502670018103 -2.226139776105281 ESQSVEEALK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESQSVEEALKK 11 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 3226900.0 1213100.0 1104000.0 909800.0 True False 1590385.8476771116 939287.5033582943 815662.623417845 1.0 0.5906035348152779 0.5128709014917272 20.60094539332337 -13.999999999999998 0.2336180141354248 3.6284259355482895 0.4763545823113115 0.999514942350829 0.004706148993571418 13.406653831585219 0.15301503853803508 16.37902188309161 0.039461416903833986 1.0000000000000041e-14 13.999999999999998 -3.152071353236978 ESQSVEEALK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESQSVEEALKK 11 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 5401600.0 1929600.0 1798300.0 1673700.0 True False 1868345.9042096392 2516370.56801061 1235307.7600762728 1.0 1.3468440519182676 0.6611772248880441 20.833330148616714 -6.769183983716489 1.5775936205299634 1.1991475148623405 0.6574403865882501 0.7274275696700812 0.1461464875263986 0.2677491445515233 1.3149932852041932 0.07302596684925527 0.1739613987481008 1.701437561812446e-07 6.769183983716489 -0.5417071282740904 ESQSVEEALK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESQSVEEALKK 11 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 3080710.0 1213100.0 943940.0 923670.0 True False 1661615.8527948414 902233.6096078457 705518.1695807811 1.0 0.5429856775200398 0.4245976399383155 20.664155454846263 -13.999999999999998 0.1896402115348779 3.446834159105504 0.33935676106339807 0.999489609100896 0.005604945722501215 12.344896033040843 0.13809836640643883 11.16035992583515 0.08165060287414153 1.0000000000000041e-14 13.999999999999998 -3.1074773980421058 ESQSVEEALK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESQSVEEALKK 11 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 6165800.0 1929600.0 3025700.0 1210500.0 True False 1604547.895774013 3009399.9535455727 1463609.9532803767 1.0 1.8755438597199852 0.9121634555971608 20.61373542405099 -6.667507272124171 1.9464942713241418 1.560065664699558 0.9161244268655021 0.2678970791388856 0.37213015967822105 0.4668885576461493 3.4080474629260906 0.15405249021420814 0.4128893935283765 2.1502686734678244e-07 6.667507272124171 -0.643941237834056 ESQSVEEALK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESQSVEEALKK 11 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 6926500.0 1802200.0 1336700.0 3787600.0 True False 2332983.4266730156 1262311.4699462657 3098295.6640578844 1.0 0.5410717690979927 1.3280401517794977 21.15374462789293 -6.748645794284214 1.655069623660508 0.7297052814813991 1.3294244076770279 0.6430483343395901 0.1928321495959942 0.30240675919065774 1.6294312747804152 0.09205879409717221 0.22379389565941696 1.7838330485770864e-07 6.748645794284214 0.5997191261956287 ESSIIGVTLFSSTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESSIIGVTLFSSTK 14 0 Q08257-3;Q08257;Q08257-2 Q08257-3 CRYZ Quinone oxidoreductase 0 3557330.0 775630.0 1702600.0 1079100.0 False True 1016858.4412116057 1448578.716682821 967445.0834581181 1.0 1.4245628083264104 0.9514058636376066 19.955687422190476 -6.670200510922326 1.936619125598981 1.2709489280565252 0.9533148319277913 0.27995910979401895 0.18033647395779692 0.46065370839507674 3.330985626561693 0.07496030794498848 0.20022591981748183 2.136975234216065e-07 6.670200510922326 -0.31763409612873383 ESSIIGVTLFSSTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESSIIGVTLFSSTK 14 0 Q08257-3;Q08257;Q08257-2 Q08257-3 CRYZ Quinone oxidoreductase 0 6384400.0 3035300.0 1676700.0 1672400.0 False True 2938946.0629392182 2346215.0538749914 1234348.2690754351 1.0 0.7983185140623367 0.4199969113556894 21.486867451469543 -6.961278888817273 0.4170212241477097 1.0172685303584865 0.18684519450375833 0.9998147227907364 0.003272478849525209 0.07924743254404192 0.019466633419748896 0.004885408880559563 0.031518991223719164 1.0932540910394776e-07 6.961278888817273 -0.8304233358547282 down ESSIIGVTLFSSTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESSIIGVTLFSSTK 14 0 Q08257-3;Q08257;Q08257-2 Q08257-3 CRYZ Quinone oxidoreductase 0 5397330.0 775630.0 1562500.0 3059200.0 False True 1062401.3716126154 1493463.583503462 2336679.966201706 1.0 1.4057432750077672 2.1994323695712734 20.018897483713367 -6.960476220857248 0.4286690776367274 0.9680247920512199 2.6675207854013236 0.9997874565046496 0.007262181588253407 0.0795314362419153 0.020505949143493872 0.010336599088233374 0.06592137426499543 1.0952765239477196e-07 6.960476220857248 1.6994959933501037 up ESSLK(ub)YQTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESSLKYQTR 9 1 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 11277100.0 3602000.0 5900100.0 1775000.0 True False 4722256.881817616 5019828.07840967 1591340.0270022792 1.0 1.0630146144183326 0.33698717939922107 22.171045092899234 -6.885767101659416 1.0470781311290682 1.0430598469041414 0.2794802493027796 0.9780485632565397 0.048657144734184546 0.12264563508251848 0.2424379680906782 0.03558883389839152 0.08747540036783276 1.300867004681148e-07 6.885767101659416 -0.7635795976013618 down ESSLK(ub)YQTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESSLKYQTR 9 1 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 10723500.0 4893900.0 4404800.0 1424800.0 True False 4738545.823285428 6163659.610728554 1051602.1369162172 1.0 1.3007491835237834 0.22192507493514083 22.176012958529714 -6.832314794563594 1.3175635985809069 1.1604589491898356 0.19150357919179256 0.9104208973174643 0.13605200904074904 0.1779716369578223 0.6034154493647873 0.08105642934336708 0.1865288284788672 1.4712456962486567e-07 6.832314794563594 -0.9689553699980431 down ESSLK(ub)YQTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESSLKYQTR 9 1 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 6597400.0 2828400.0 1070000.0 2699000.0 True False 4290889.583737575 879050.1400518427 2165541.4669862753 1.0 0.20486431144335038 0.504683568459476 22.032845346419844 -10.459675427064953 6.07560257649334 1.0003364453515626 0.3547739399688628 0.860628980140723 0.12240069912497917 0.000558092527091041 4.963311118239787e-05 0.11857311808979297 0.03950465577293235 3.469960834538693e-11 10.459675427064953 -0.6455625053826999 ESSLK(ub)YQTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESSLKYQTR 9 1 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 9263500.0 3602000.0 3988200.0 1673300.0 True False 4933756.74038992 3811988.1367862457 1278101.002695251 1.0 0.7726339861022374 0.25905229421470044 22.234255154422126 -6.963441704072941 0.46978838032881814 1.0135964898974787 7.231363792682298e-17 0.9996718731156069 0.005614009208049569 0.07961130308443329 0.024392271089985724 0.007057708619037317 0.04185929380718618 1.0878231477820031e-07 6.963441704072941 -1.0135964898974787 down ESSLK(ub)YQTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESSLKYQTR 9 1 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 12913700.0 4893900.0 6813200.0 1206600.0 True False 4069494.686530084 6776495.939285687 1458894.4813119392 1.0 1.6651934604351994 0.3584952417165797 21.95641823396399 -6.7683077743069475 1.5808526719957843 1.3823569523415822 0.35159633958501185 0.7240872402609426 0.28022659738441347 0.26916800445006966 1.3272789396251055 0.13974265452440238 0.3331752455727851 1.704873756769004e-07 6.7683077743069475 -1.0307606127565703 ESSLK(ub)YQTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESSLKYQTR 9 1 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 4908590.0 2828400.0 948390.0 1131800.0 True False 3661419.556099187 895611.2627981892 925824.0132486824 1.0 0.2446076580615519 0.25285930745260976 21.803971668512293 -10.656881781194423 10.10650193594103 1.000255899295839 0.24873348275969256 0.9999095274748249 0.0033687217574065445 1.9429862485355304e-05 6.596473897059048e-07 0.0032627460305485246 0.001087250272036845 2.2035262007766357e-11 10.656881781194423 -0.7515224165361465 ESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSK 36 1 P08172 P08172 CHRM2 Muscarinic acetylcholine receptor M2 0 21528200.0 3940100.0 8564500.0 9023600.0 False True 5977419.759894087 7036098.06025607 7240081.504815628 1.0 1.1771129254574455 1.2112385938483787 22.511091427840356 -13.745446016783221 0.2344398912094018 1.4857340837475558e-09 1.2273017480341488 0.9995026349245227 0.0020648930116055246 11.934338149522427 0.15215121324936492 5.557701150847824 0.01725050928737321 1.7970244381366435e-14 13.745446016783221 1.2273017465484148 ESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSK 36 1 P08172 P08172 CHRM2 Muscarinic acetylcholine receptor M2 0 7936900.0 1853300.0 1810600.0 4273000.0 False True 1541101.065110894 1800845.9384240366 5166464.543880255 1.0 1.16854499629747 3.3524501804873443 20.555530045942103 -6.922317412025999 0.8073647141919481 0.9557193096042462 3.72409281614776 0.9948006108098857 0.07725816657419521 0.09682719804486645 0.09869232288798517 0.06739613072801663 0.20657766971171612 1.1958661912625634e-07 6.922317412025999 2.768373506543514 up ESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSK 36 1 P08172 P08172 CHRM2 Muscarinic acetylcholine receptor M2 0 20357400.0 3940100.0 7687000.0 8730300.0 False True 5100537.120982329 7259211.69258393 7141474.980442642 1.0 1.4232249507059473 1.4001417519469483 22.282217749932805 -10.15714698215115 4.842123655255945 0.9999658528906085 1.4116833513281906 0.9976476389506298 0.009423676437829365 3.4742310908315225e-06 6.047373086936647e-07 0.009125190956235842 0.003041478491121728 6.963907884841457e-11 10.15714698215115 0.4117174984375821 ESSPK(ub)QYMQLGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESSPKQYMQLGGR 13 1 Q5T8U5;O15260;B7Z1G8 Q5T8U5 SURF4 Surfeit locus protein 4 1 32461400.0 1417400.0 13024000.0 18020000.0 True False 2150299.425820128 10699765.443023548 14458339.10155341 1.0 4.975942101153024 6.723872465360945 21.036106136147346 -8.854425246144977 0.3594678337675565 6.803713180688111e-19 7.221733677369207 0.9978674135714283 0.11060294509790851 0.3687963184184846 0.1225540414689247 1.0339772668520715 0.4857158145939459 1.3982175657628017e-09 8.854425246144977 7.221733677369207 ESSPK(ub)QYMQLGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESSPKQYMQLGGR 13 1 Q5T8U5;O15260;B7Z1G8 Q5T8U5 SURF4 Surfeit locus protein 4 1 22544500.0 1417400.0 8669100.0 12458000.0 True False 1834852.241131027 8186656.964248637 10190771.82987462 1.0 4.461752712688338 5.554001353042409 20.807232458239795 -9.279962914952694 0.38627122046814233 4.2090273009095536e-23 5.749069923034944 0.9980472971621929 0.08578216559315884 0.6643799083518594 0.15108540338467763 1.2775431719026944 0.28513241248992194 5.248522762474208e-10 9.279962914952694 5.749069923034944 ESSTVFELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESSTVFELK 9 0 B8ZZU8;Q15370;Q15370-2;I3L0M9;A0A0B4J296 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 0 18762100.0 3436600.0 7204500.0 8121000.0 False True 4505415.880081739 6129616.682921052 7280716.8221326815 1.0 1.360499640004342 1.6159921782849027 22.10322885193107 -6.974835269613118 0.08279204656744103 0.14827172082301285 2.8346399996286364 0.9999998836752948 8.599083044396148e-05 0.07476297630323854 0.002405234092898569 0.029439754852037595 0.04826150754652155 1.0596555823967148e-07 6.974835269613118 2.686368278805624 ESSTVFELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESSTVFELK 9 0 B8ZZU8;Q15370;Q15370-2;I3L0M9;A0A0B4J296 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 0 13785300.0 3436600.0 4966400.0 5382300.0 False True 4707203.890622988 4746968.026311429 4111111.591948036 1.0 1.008447506547922 0.8733659487615565 22.166438913453963 -6.891999379750392 1.0104533846454666 1.0069140139627781 0.8612809582785077 0.9821483635282535 0.008254863953567686 0.11753694590979283 0.21247894605229037 0.006207668031180416 0.015591882928986668 1.282332414053016e-07 6.891999379750392 -0.14563305568427043 ESSTVFELK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESSTVFELKR 10 1 B8ZZU8;Q15370;Q15370-2;I3L0M9;A0A0B4J296 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 3718610.0 718630.0 735080.0 2264900.0 True False 984326.9312455343 702601.7350155048 1729977.267079708 1.0 0.7137889990741756 1.7575230466270517 19.90877804177957 -6.833605712565276 1.311668772570556 0.8474054763868536 1.7877457656157076 0.9129032163145439 0.12995553280254574 0.1764044253629853 0.5922699629460865 0.07775890732107346 0.17895758935268 1.4668789872407113e-07 6.833605712565276 0.940340289228854 ESSTVFELK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESSTVFELKR 10 1 B8ZZU8;Q15370;Q15370-2;I3L0M9;A0A0B4J296 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 3182120.0 587020.0 1352700.0 1242400.0 True False 488133.1393953463 1345412.7366100724 1502180.09579144 1.0 2.7562413366907315 3.0773983050038365 18.896915174167535 -10.16226365866048 0.3866977776479579 2.861248607844807e-13 3.1174245751518987 0.9990078547040732 0.028759875882394467 1.529653112932683 0.1767435366875854 1.7456228919448802 0.08474282242444267 6.882343448258696e-11 10.16226365866048 3.1174245751516128 ESSYACYYDEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESSYACYYDEK 11 0 Q99538;Q99538-2;Q99538-3 Q99538 LGMN Legumain 0 19013100.0 2811500.0 9024600.0 7177000.0 False True 3685903.726604734 7678164.85761528 6434392.886645276 1.0 2.0831159539503252 1.7456757864298071 21.813586958533765 -10.06830462168419 4.381292444244291 0.9999295447323651 1.9143958702038983 0.9073275956875946 0.13775937188115958 15784121.367222061 7254455.809082317 10876.141443613016 0.04715869796575394 8.544671645490809e-11 10.06830462168419 0.9144663254715333 ESSYACYYDEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESSYACYYDEK 11 0 Q99538;Q99538-2;Q99538-3 Q99538 LGMN Legumain 0 6324180.0 3302500.0 442780.0 2578900.0 False True 3197663.945197105 619584.3630671963 1903408.724658361 1.0 0.1937615627176248 0.5952497689812849 21.60858689773818 -10.905441481739704 11.057505245245244 1.0545166011667992 0.39450566584945557 0.752020250519673 0.16390687384854208 0.08207252945124253 0.0007018440083530084 0.059128308999093354 0.05290071606202699 1.2432501441536676e-11 10.905441481739704 -0.6600109353173437 ESSYACYYDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESSYACYYDEK 11 0 Q99538;Q99538-2;Q99538-3 Q99538 LGMN Legumain 0 15441300.0 2811500.0 6089400.0 6540400.0 False True 3850987.5279306737 5820350.173047029 4995692.223766215 1.0 1.5113915926324986 1.297249650260656 21.876797020056657 -10.041315368962609 4.316845965986339 0.9999714427945313 1.4043206214666715 0.8261840039101852 0.08742308214571491 11302876.024774363 6572840.333718046 2875.735795666352 0.02992724564254333 9.092527663338552e-11 10.041315368962609 0.40434917867214015 ESSYACYYDEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESSYACYYDEKR 12 1 Q99538;Q99538-2;Q99538-3 Q99538 LGMN Legumain 1 11598200.0 1203900.0 1141800.0 9252500.0 True False 1578324.558584186 971447.8907015411 8295140.056247097 1.0 0.6154931097143701 5.255661778264502 20.58996247360675 -6.886790286680595 1.0411528675137287 0.7311593722545668 5.630580864222911 0.9787642529339953 0.30640628892410104 0.12178729038424321 0.2373542021231209 0.22512279911149957 0.5551414232407219 1.2978058077542465e-07 6.886790286680595 4.8994214919683445 up ESSYACYYDEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESSYACYYDEKR 12 1 Q99538;Q99538-2;Q99538-3 Q99538 LGMN Legumain 1 8793080.0 823880.0 1021300.0 6947900.0 True False 797726.3803691119 1429110.4160091416 5128036.557467841 1.0 1.7914794485646635 6.428315126165281 19.605534462267546 -6.936342126473939 0.6927552591396686 0.9432240473829059 7.554738150549451 0.997644494365599 0.11620302387644928 0.08947567029497776 0.06250970601847063 0.1101954426424837 0.4059291168847959 1.1578648594223442e-07 6.936342126473939 6.611514103166545 ESSYACYYDEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESSYACYYDEKR 12 1 Q99538;Q99538-2;Q99538-3 Q99538 LGMN Legumain 1 127052410.0 790110.0 16757300.0 109505000.0 True False 1198654.634778284 13766828.889617525 87861288.75225358 1.0 11.485233936599249 73.29991992940097 20.192984608004192 -6.936209229043722 0.6939421793013634 0.2401159191688079 88.260770610824 0.9976238737132428 1.5549639327719602 0.08953966919748885 0.06281090195316034 1.4732358129018732 5.415061960345548 1.1582192291345554e-07 6.936209229043722 88.0206546916552 ESSYACYYDEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESSYACYYDEKR 12 1 Q99538;Q99538-2;Q99538-3 Q99538 LGMN Legumain 1 15818970.0 1203900.0 866570.0 13748500.0 True False 1649014.364174191 828282.0720362215 10501387.459245587 1.0 0.5022891795433307 6.36828137303981 20.65317253512964 -6.886280558625635 1.0441821991955726 0.6561354455501772 6.837438851543343 0.9784069353268482 0.3902480579815541 0.12221106003472232 0.23991671053344563 0.2860760421808946 0.7042507208706136 1.299329926583203e-07 6.886280558625635 6.181303405993166 up ESSYACYYDEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESSYACYYDEKR 12 1 Q99538;Q99538-2;Q99538-3 Q99538 LGMN Legumain 1 25855080.0 823880.0 932100.0 24099100.0 True False 685092.7240724992 927078.5922926349 29138110.388351206 1.0 1.3532162285736489 42.53163019326957 19.385939737701822 -6.90664582897275 0.9191295431523957 1.3203687950143059e-14 47.473074464673616 0.9905393605017927 1.896243597216441 0.10353564848984884 0.14701875698903363 1.5486204582166017 4.177426075440233 1.2398072482521251e-07 6.90664582897275 47.4730744646736 up ESSYACYYDEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESSYACYYDEKR 12 1 Q99538;Q99538-2;Q99538-3 Q99538 LGMN Legumain 1 104359010.0 790110.0 11188900.0 92380000.0 True False 1022812.9703965249 10566227.879166422 75567787.89884551 1.0 10.330557183949377 73.88231288223626 19.96411093009664 -6.933215507978293 0.7199152397473554 0.1393386950293877 88.06565420523195 0.997133204518869 1.7338461728175003 0.09100249513653465 0.06975230279819257 1.6109834908818863 5.652123972080913 1.1662307600577283e-07 6.933215507978293 87.92631551020256 ESTAEKDEL ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESTAEKDEL 9 1 P14625;Q58FF3 P14625 HSP90B1;HSP90B2P Endoplasmin;Putative endoplasmin-like protein 0 17717800.0 6137000.0 1987400.0 9593400.0 False True 5942184.294223964 2780979.1841540867 7080600.74416903 1.0 0.46800621563644657 1.1915821512051807 22.502561919741503 -6.709701721168182 1.7966000429809121 0.6728410288029782 1.1898446885260194 0.46358832969621155 0.22418914933895656 0.37564688879475566 2.363456090688722 0.09931763876578079 0.2523734364067276 1.9511842371781782e-07 6.709701721168182 0.5170036597230412 ESTGAQVQVAGDMLPNSTER ddPTM_RPMI8226_Bortezomib_1h_R1 2 ESTGAQVQVAGDMLPNSTER 20 0 Q15365;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8VXH9;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 0 108670990.0 24512790.0 42341800.0 41816400.0 False True 32136505.07219602 36024568.48704372 37489640.05923273 1.0 1.1209858821335115 1.1665748959014262 24.937709704949103 -13.999999999999444 0.13540357863605107 0.4239784230696866 1.226244739362643 0.999621871574903 0.0013667673289477662 11.932231763722633 0.11493185495308213 1.8213251773663488 0.05319698080241697 1.0000000000012802e-14 13.999999999999444 0.8022663162929564 ESTGAQVQVAGDMLPNSTER ddPTM_RPMI8226_Bortezomib_2h_R1 2 ESTGAQVQVAGDMLPNSTER 20 0 Q15365;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8VXH9;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 0 85301200.0 21718600.0 10491300.0 53091300.0 False True 21029154.93116056 14680530.801406747 39185095.82514032 1.0 0.6981036969609009 1.8633699715187635 24.325887539905565 -6.837929531117377 1.2920819353721078 0.8393344970154006 1.900126705198996 0.9208166694558292 0.13894822008770322 0.17123269560685514 0.5562129772193036 0.08435426420698798 0.19423016699187257 1.452347257205112e-07 6.837929531117377 1.0607922081835954 ESTGAQVQVAGDMLPNSTER ddPTM_RPMI8226_Bortezomib_8h_R1 2 ESTGAQVQVAGDMLPNSTER 20 0 Q15365;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8VXH9;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 0 252531900.0 23725000.0 183490900.0 45316000.0 False True 35992559.52983105 150745515.27405483 36359272.73729164 1.0 4.188241048795521 1.0101885837587252 25.10119536413172 -6.645416779952326 2.0247778687558 3.076265398584718 1.0234620244512167 0.1757697099178438 1.3623112996214786 0.519820661214252 4.0793848005275555 0.5466466010135697 1.5088162204343203 2.2624720359344925e-07 6.645416779952326 -2.052803374133501 ESTGAQVQVAGDMLPNSTER ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ESTGAQVQVAGDMLPNSTER 20 0 Q15365;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8VXH9;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 0 105998290.0 24512790.0 37693500.0 43792000.0 False True 33575830.89624172 36028076.53426423 33449231.524550498 1.0 1.073036037309117 0.9962294493297145 25.000919766471995 -6.6575725925656 1.9816119936837147 1.0471061385710132 0.9965514451583856 0.22531781439787923 0.031115229125158357 0.49020805437801795 3.697848675974039 0.012697617722998166 0.03448195176454375 2.2000239436692045e-07 6.6575725925656 -0.05055469341262764 ESTGAQVQVAGDMLPNSTER ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ESTGAQVQVAGDMLPNSTER 20 0 Q15365;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8VXH9;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 0 51071300.0 21718600.0 16041500.0 13311200.0 False True 18059978.197117247 15955081.255511545 16094510.375965098 1.0 0.8834496410443238 0.8911699781860268 24.10629281533984 -10.353754805003401 8.144026012444934 1.0000006149622191 0.8873098096153149 0.9964921830374844 0.0031518144399049408 3.519178514223388e-08 2.7919136346953373e-09 0.0030517478523072136 0.0010172437363406628 4.4283832049485405e-11 10.353754805003401 -0.11269080534690423 ESTGAQVQVAGDMLPNSTER ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ESTGAQVQVAGDMLPNSTER 20 0 Q15365;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8VXH9;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 0 110071700.0 23725000.0 52858500.0 33488200.0 False True 30712480.189666726 49916878.00864412 27393691.217948895 1.0 1.6252962216134779 0.8919400533196129 24.87232168622417 -6.680901590185453 1.8986577645168536 1.3953244998058276 0.894717489817832 0.3281512071671887 0.26496598568155033 0.4365936107625823 3.043704922801527 0.11194663148323106 0.2949139677660297 2.084963275938892e-07 6.680901590185453 -0.5006070099879957 ESTIHTAHQFLMDTIFQPFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESTIHTAHQFLMDTIFQPFLK 21 0 Q9NU22 Q9NU22 MDN1 Midasin 0 35886200.0 7136200.0 10077000.0 18673000.0 False True 10826137.126102442 8278680.618039634 14982273.365333365 1.0 0.7646938627887186 1.3838983555094864 23.36801523096763 -6.803745877397815 1.4407589435920098 0.8707816625318848 1.39323861956122 0.8428354834901569 0.10117297083195331 0.2154575056860176 0.882565906014711 0.05523584423793898 0.12816552652029842 1.5712819536107339e-07 6.803745877397815 0.5224569570293353 ESTIHTAHQFLMDTIFQPFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESTIHTAHQFLMDTIFQPFLK 21 0 Q9NU22 Q9NU22 MDN1 Midasin 0 18807600.0 7136200.0 5267500.0 6403900.0 False True 9237951.575532129 4974358.994495356 5238455.909562857 1.0 0.5384699144419168 0.5670581694146961 23.139141553060078 -10.735990830378281 6.861110591289252 1.006904632632442 0.552764041928453 0.9969448371515545 0.011671106219982174 0.0012369822020384153 4.759786375343144e-05 0.01133997790995035 0.003766833335150732 1.836577120123936e-11 10.735990830378281 -0.45414059070398904 ESTK(ub)MAEAIR ddPTM_RPMI8226_Bortezomib_1h_R1 2 ESTKMAEAIR 10 1 Q9Y232-2;Q9Y232;Q9Y232-3;Q9Y232-4;C9JQG7 Q9Y232-2 CDYL Chromodomain Y-like protein 1 49387200.0 17698800.0 18910100.0 12778300.0 True False 23203298.195422996 16088786.790992472 11456124.094108852 1.0 0.6933836153588757 0.49372826214717386 24.467826553701663 -8.519007275343784 0.12164955064172828 1.4988579347220856 7.739003609323223e-06 0.9999545831418366 0.0014032012971257975 0.15989321626236358 0.03005306256196292 0.1835527917176595 0.16112947268510258 3.0268627213752127e-09 8.519007275343784 -1.4988501957184763 ESTK(ub)MAEAIR ddPTM_RPMI8226_Bortezomib_2h_R1 2 ESTKMAEAIR 10 1 Q9Y232-2;Q9Y232;Q9Y232-3;Q9Y232-4;C9JQG7 Q9Y232-2 CDYL Chromodomain Y-like protein 1 64698200.0 18399900.0 25349100.0 20949200.0 True False 17815805.246096056 35471127.823810145 15461976.057471378 1.0 1.9909921181689425 0.8678797193777997 24.086654356680505 -6.673763041507197 1.9239240925161558 1.630491893463089 0.8723315746087106 0.2958238507240788 0.420591341869085 0.4525640666325472 3.2330017632891237 0.17576668151983602 0.4673309953731368 2.1195172646667408e-07 6.673763041507197 -0.7581603188543784 ESTK(ub)MAEAIR ddPTM_RPMI8226_Bortezomib_8h_R1 2 ESTKMAEAIR 10 1 Q9Y232-2;Q9Y232;Q9Y232-3;Q9Y232-4;C9JQG7 Q9Y232-2 CDYL Chromodomain Y-like protein 1 85479700.0 36658400.0 27804300.0 21017000.0 True False 55613472.88802347 22842405.42901254 16862980.737921648 1.0 0.4107351014565343 0.3032175453576671 25.728931095975373 -13.999999999999998 0.23926093656113356 4.886449458928692 0.2553442949904443 0.9995237446299695 0.006684157070331844 13.597432085467258 0.1548183855129804 25.238204492093402 0.052766238165800686 1.0000000000000041e-14 13.999999999999998 -4.631105163938248 ESTK(ub)MAEAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ESTKMAEAIR 10 1 Q9Y232-2;Q9Y232;Q9Y232-3;Q9Y232-4;C9JQG7 Q9Y232-2 CDYL Chromodomain Y-like protein 1 45113800.0 17698800.0 14485400.0 12929600.0 True False 24242524.652085822 13845387.131187899 9875894.773470683 1.0 0.5711198536410128 0.40737897208329593 24.531036615224554 -13.999999999999998 0.13343369194093763 3.0400098395613506 0.18776572421319979 0.9996303580941392 0.00480415996710382 11.93293068225442 0.11392070716900843 6.36613572415863 0.19559299894071833 1.0000000000000041e-14 13.999999999999998 -2.852244115348151 ESTK(ub)MAEAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ESTKMAEAIR 10 1 Q9Y232-2;Q9Y232;Q9Y232-3;Q9Y232-4;C9JQG7 Q9Y232-2 CDYL Chromodomain Y-like protein 1 58364150.0 18399900.0 31264700.0 8699550.0 True False 15300332.10377916 31096270.85554297 10518585.682825522 1.0 2.032391888269029 0.6874743379084854 23.86705963211478 -6.7016398921538105 1.8252068032029793 1.6400433080709675 0.6913728275916059 0.42530756509077383 0.4356557278924196 0.3921063979840028 2.540715601749682 0.19034732408854166 0.48850095256880277 1.9877424284187992e-07 6.7016398921538105 -0.9486704804793616 ESTK(ub)MAEAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ESTKMAEAIR 10 1 Q9Y232-2;Q9Y232;Q9Y232-3;Q9Y232-4;C9JQG7 Q9Y232-2 CDYL Chromodomain Y-like protein 1 79986100.0 36658400.0 26044000.0 17283700.0 True False 47455021.44509492 24594628.505484067 14138243.945738 1.0 0.5182724136778624 0.29792935531797904 25.500057418067822 -11.146481988186084 0.1473049143252763 2.0502498961399853 8.39111565098236e-08 0.999661818475039 0.00539123183390214 3.488902078887724 0.08786942956617647 1.4324089557868533 0.21107075746896473 7.137038044705716e-12 11.146481988186084 -2.0502498122288286 ESTLHLVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESTLHLVLR 9 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 970630000.0 375620000.0 193000000.0 402010000.0 False True 492441457.5092541 164205152.3081076 360413861.55221796 1.0 0.333451113435188 0.7318917935447077 28.875376983198446 -10.813574935724573 6.982228871077938 1.0233324231678178 0.532671453490288 0.6471716504970695 0.16266272650597033 0.05438037952721674 0.0014519507920780104 0.14496798897174265 0.05249916923385958 1.5361197193312004e-11 10.813574935724573 -0.4906609696775298 ESTLHLVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESTLHLVLR 9 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 548130000.0 181680000.0 142210000.0 224240000.0 False True 175912667.8466043 198995194.61535275 165504816.9441975 1.0 1.131215830282765 0.9408351255778667 27.390284137198243 -6.721261609197645 1.754460317346426 1.0797260019342851 0.9411061674801606 0.5184263628809358 0.05520851945153192 0.35296420710970466 2.1239249353948915 0.024977087919256902 0.06261644529763938 1.89993345810033e-07 6.721261609197645 -0.1386198344541245 ESTLHLVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESTLHLVLR 9 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 1306310000.0 216550000.0 635900000.0 453860000.0 False True 328522181.92560166 522418676.6906227 364154372.0660957 1.0 1.5902082277321887 1.1084620524910658 28.291415544178175 -10.13397089677494 4.273741405653504 0.9999336166438411 1.349335140051341 0.41214885688764835 0.1966720525961786 137361203.55217835 12.83284165599877 93959.7729655684 0.0673260747563362 7.345630915287596e-11 10.13397089677494 0.34940152340749986 ESTLHLVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESTLHLVLR 9 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 989840000.0 375620000.0 199680000.0 414540000.0 False True 514496864.7488235 190857477.346542 316634189.7192904 1.0 0.3709594565551304 0.6154249159008396 28.938587044721338 -10.275767140341408 5.632955673661844 1.000042196041053 0.493192186228008 0.8514219904831468 0.09980260585538013 5.2891744679874716e-05 6.800113037397912e-06 0.09664147354263436 0.03221115253216129 5.2994751455153694e-11 10.275767140341408 -0.5068500098130451 ESTLHLVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESTLHLVLR 9 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 416030000.0 181680000.0 78370000.0 155980000.0 False True 151074969.7886728 77947805.25477295 188594696.8299654 1.0 0.5159544652817615 1.248351709709266 27.17068941263252 -6.7284616434942714 1.7286183377271058 0.708208547247024 1.2478124963192831 0.5522055500118319 0.20350733080834918 0.3391354753518009 1.9845437702668574 0.09331785978300543 0.23198585970040034 1.8686947114372134e-07 6.7284616434942714 0.5396039490722592 ESTLHLVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESTLHLVLR 9 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 1116050000.0 216550000.0 589560000.0 309940000.0 False True 280328243.83866453 556750467.7351081 253534100.25295696 1.0 1.9860662632892998 0.9044186799774331 28.062541866270625 -6.666816454547326 1.9488472564171004 1.6311164292159424 0.9088616063463375 0.26498752492912847 0.41916894615931755 0.46843971835326365 3.4269306620530315 0.1733542183218576 0.46505834672788726 2.153691755053069e-07 6.666816454547326 -0.7222548228696049 ESTNYPGDYTLCVSCDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESTNYPGDYTLCVSCDGK 18 0 P41240;H3BU69 P41240 CSK Tyrosine-protein kinase CSK 0 5053100.0 1180900.0 2014400.0 1857800.0 False True 1548171.3358518665 1713859.3720697009 1665572.677275963 1.0 1.1070217697362714 1.075832266562084 20.562133712450766 -10.092556459531648 4.479575759336613 0.9999923449110119 1.0914270181511048 0.9197238382678645 0.012733061367683728 1.0011971199679834e-06 2.0283494495643851e-07 0.012329795151259109 0.004109577882964967 8.080598721765259e-11 10.092556459531648 0.09143467324009291 ESVFTVEGGHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESVFTVEGGHR 11 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6;F5H2D2;F5H0C5 Q99623 PHB2 Prohibitin-2 0 37828300.0 10708700.0 14637500.0 12482100.0 False True 14039209.403198306 12453642.056528125 11190572.028757825 1.0 0.8870614931985438 0.7970941744204253 23.742958358956585 -6.973694325426845 0.1449112735607666 1.112353406048062 0.5694461487005795 0.9999987447530541 9.282625016830517e-05 0.07512111121134159 0.00440815478577284 0.004833609686675213 0.011465208104466747 1.0624430858610622e-07 6.973694325426845 -0.5429072573474825 ESVFTVEGGHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESVFTVEGGHR 11 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6;F5H2D2;F5H0C5 Q99623 PHB2 Prohibitin-2 0 26907600.0 8372700.0 1589500.0 16945400.0 False True 8106913.2214842765 2224195.6391329975 12506891.38889675 1.0 0.27435789410433264 1.542743957805298 22.95072126949272 -6.75154869921947 1.6442307149713773 0.5741116770543919 1.5455498287390654 0.6555784927481243 0.30494450967141135 0.2973423953415083 1.5820842712194603 0.14648318857875134 0.355028863012481 1.77194933805582e-07 6.75154869921947 0.9714381516846735 ESVFTVEGGHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESVFTVEGGHR 11 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6;F5H2D2;F5H0C5 Q99623 PHB2 Prohibitin-2 0 34706300.0 10708700.0 9458900.0 14538700.0 False True 14667995.781736126 9040974.521600584 11104958.493925435 1.0 0.6163742242725462 0.7570876525443775 23.806168420479477 -10.059289856502875 5.631132325960305 1.0000015799893194 0.6867309397161251 0.8685679863201086 0.05744601653760867 1.139527779422692e-06 1.9031492621289264e-07 0.05562214728944881 0.018540622112962386 8.723889248697588e-11 10.059289856502875 -0.3132706402731943 ESVFTVEGGHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESVFTVEGGHR 11 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6;F5H2D2;F5H0C5 Q99623 PHB2 Prohibitin-2 0 15455490.0 8372700.0 6105600.0 977190.0 False True 6962271.023500772 6072707.920933288 1181515.9109839338 1.0 0.8722309000088029 0.1697026598068059 22.731126544926997 -6.948400138815628 0.6871983662519069 1.0077634065645684 2.2047498669932009e-16 0.9978588092014783 0.01689133212280476 0.0865001509483235 0.0597902746665356 0.01620012725556871 0.05931071032110566 1.1261593869480834e-07 6.948400138815628 -1.0077634065645682 down ESVK(ub)GSLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESVKGSLDR 9 1 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 41826700.0 16235000.0 17523000.0 8068700.0 True False 21284242.21996367 14908636.704119021 7233828.32443565 1.0 0.7004541928270007 0.3398677880883465 24.34328239116641 -7.067409491863117 0.30306093304510673 1.0641986933022174 2.9940584178306513e-14 0.9999602484490101 0.0017015622511779992 0.07370618287072625 0.01189821796747793 0.006501902039221941 0.031608484062383216 8.562301337880145e-08 7.067409491863117 -1.0641986933021874 down ESVK(ub)GSLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESVKGSLDR 9 1 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 47200000.0 19323000.0 17685000.0 10192000.0 True False 18709601.94187546 24746712.72605664 7522409.446553962 1.0 1.3226744643171182 0.40206143721943405 24.15727552890508 -6.811994357493662 1.4060018059330557 1.175448922513239 0.3851911555230499 0.864991313429551 0.14013896232931972 0.20410087455456521 0.7948074970187522 0.0783613450019096 0.18111888308505467 1.541720483393074e-07 6.811994357493662 -0.7902577669901891 down ESVK(ub)GSLDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESVKGSLDR 9 1 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 36782300.0 16997000.0 10706000.0 9079300.0 True False 25785691.64714594 8795430.65364021 7284772.375401449 1.0 0.3410973331255872 0.2825121961080984 24.620067407539047 -13.999999999999998 0.34257588523256816 8.741765764850186 0.27360445922177973 0.9997403128305835 0.005242125610341073 19.942789241839122 0.1879135484366801 111.94897294761718 0.017936080697382197 1.0000000000000041e-14 13.999999999999998 -8.468161305628406 ESVK(ub)GSLDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESVKGSLDR 9 1 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 31896000.0 16235000.0 10488000.0 5173000.0 True False 22237518.234378263 10024605.48082196 3951243.9412792297 1.0 0.45079695383113133 0.17768367403385749 24.406492452689303 -9.116723737943373 0.24953049620201917 1.3381014537810125 6.6778290851405924e-21 0.9991434187899723 0.010008230122788323 0.5570003647556379 0.08789567123812686 0.27437483181034766 0.11352019501739251 7.643218269971954e-10 9.116723737943373 -1.3381014537810125 ESVK(ub)GSLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESVKGSLDR 9 1 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 49285300.0 19323000.0 24332000.0 5630300.0 True False 16067930.654042952 24200918.686476145 6807569.698434114 1.0 1.5061627540934652 0.42367432652077197 23.937680804339355 -6.779558713558494 1.537705457384595 1.2867602573339547 0.4152293404936144 0.7658158853788263 0.214008109267598 0.25124379338482344 1.1734046705943133 0.10962293644381677 0.2587472109829296 1.6612740700178577e-07 6.779558713558494 -0.8715309168403403 down ESVK(ub)GSLDRK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESVKGSLDRK 10 2 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 4397820.0 1712500.0 1856000.0 829320.0 True False 2245104.083873589 1579092.034631335 743509.9217991728 1.0 0.7033491435759404 0.3311694665471181 21.09835089972821 -7.061705307535199 0.3156330571767795 1.0570453223536254 5.539726835866612e-11 0.9999526261588422 0.0018833403937978973 0.07342184435138463 0.012528124017224253 0.006248448281404776 0.03192149878180247 8.67550356255398e-08 7.061705307535199 -1.0570453222982281 down ESVK(ub)GSLDRK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESVKGSLDRK 10 2 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 3382960.0 1330600.0 1494900.0 557460.0 True False 1288360.831333616 2091821.3658005132 411444.50255847466 1.0 1.6236300537289807 0.3193550227171822 20.297105275098765 -6.776655755760392 1.5486440119165241 1.3546408856681085 0.31003812647923906 0.7554848645708586 0.26338115646174814 0.2557947544506744 1.211429572530392 0.13397887800938402 0.31706277151716933 1.6724157321599586e-07 6.776655755760392 -1.0446027591888694 ESVK(ub)GSLDRK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESVKGSLDRK 10 2 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 4684320.0 1712500.0 2164800.0 807020.0 True False 2345657.5285723875 2069151.9779637125 616418.4970986198 1.0 0.8821202382527846 0.2627913451090126 21.1615609612511 -6.938706999867378 0.6714893575228231 1.0071317117042882 0.1019473096098261 0.9979895231085626 0.014498041500551118 0.08836163882299038 0.0573342581543255 0.013978099368855901 0.05361525745619658 1.1515770472911166e-07 6.938706999867378 -0.905184402094462 down ESVK(ub)GSLDRK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESVKGSLDRK 10 2 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 4249590.0 1330600.0 2588900.0 330090.0 True False 1106452.8555746793 2574953.0818435834 399110.29283628165 1.0 2.3272144573265 0.3607115213498981 20.07751055053304 -6.724890451625667 1.7414217258142208 1.8032305583625747 0.3628473145483828 0.5355196110279545 0.5581932724613133 0.3459526062644601 2.052748063060712 0.254243036723588 0.634674828480688 1.884124289456102e-07 6.724890451625667 -1.440383243814192 ESVLIISTDPAHNISDAFDQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESVLIISTDPAHNISDAFDQK 21 0 O43681 O43681 ASNA1 ATPase ASNA1 0 10146300.0 1882300.0 2660100.0 5603900.0 False True 1822547.4168189282 3722291.802238242 4136070.476603592 1.0 2.0423566311021553 2.2693897774263037 20.797524918647106 -10.604982677925243 0.3123648108315625 2.319513597425583e-15 2.3321535512006153 0.999127943763633 0.01632187587536578 2.2081818427186093 0.1525723247969805 1.7861690335361122 0.07741049483363968 2.4832321484031503e-11 10.604982677925243 2.332153551200613 ESVLIISTDPAHNISDAFDQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESVLIISTDPAHNISDAFDQK 21 0 O43681 O43681 ASNA1 ATPase ASNA1 0 4668100.0 1221400.0 1437400.0 2009300.0 False True 1672984.5870939083 1373890.9151538408 1534744.7228324665 1.0 0.8212215018312785 0.9173693139029008 20.67399272347174 -10.132532634184537 4.394942126643739 1.0000144137712577 0.869295407874531 0.7113168224206671 0.039252180071371136 54821835.68460547 1.0349615212903254 11166.71129097805 0.013437065259709951 7.369997928914228e-11 10.132532634184537 -0.1307190058967267 ESVLIISTDPAHNISDAFDQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESVLIISTDPAHNISDAFDQK 21 0 O43681 O43681 ASNA1 ATPase ASNA1 0 6130400.0 1882300.0 2306600.0 1941500.0 False True 1565215.8500287232 2294173.8879757468 2347458.673518259 1.0 1.465723649510479 1.4997667404627808 20.577930194081382 -11.711238244196563 0.4221051063453469 2.2078310816877364e-18 1.5010505839739356 0.9997489391698992 0.0036125097965702463 4.672623654736087 0.21165751342338526 4.211628834608823 0.008209785018749345 1.9442931934456274e-12 11.711238244196563 1.5010505839739356 ESVLIISTDPAHNISDAFDQKFSK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESVLIISTDPAHNISDAFDQKFSK 24 1 O43681 O43681 ASNA1 ATPase ASNA1 1 25021000.0 3695000.0 9694000.0 11632000.0 True False 3072556.216254651 9641776.497891663 14064197.41970866 1.0 3.138030948590644 4.5773604874355955 21.55100797607178 -8.197348288551554 0.24281901611186066 4.639073740562728e-16 5.8717456032906465 0.9995287489297459 0.03190487125638875 0.0909153924233755 0.05351366679038361 0.4610945417462879 0.5236986329266061 6.348216235500064e-09 8.197348288551554 5.871745603290646 ESVLTATSILNNPIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESVLTATSILNNPIVK 16 0 Q5BKZ1;A0A0A0MRN4;Q5BKZ1-3 Q5BKZ1 ZNF326 DBIRD complex subunit ZNF326 0 6943700.0 1529700.0 3346400.0 2067600.0 False True 2005451.5136358724 2847130.1641650335 1853664.5858196698 1.0 1.419695337836018 0.924312840881895 20.935495655455313 -6.682231821425759 1.8942627877845484 1.2650226426117468 0.9261803543395314 0.3341746963775736 0.17779249218784962 0.43361791665686195 3.0101967015010445 0.07526525189756153 0.19791912713858742 2.0785868650370475e-07 6.682231821425759 -0.3388422882722154 ESVLTATSILNNPIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESVLTATSILNNPIVK 16 0 Q5BKZ1;A0A0A0MRN4;Q5BKZ1-3 Q5BKZ1 ZNF326 DBIRD complex subunit ZNF326 0 8847100.0 2812100.0 2270900.0 3764100.0 False True 2722831.424765716 3177682.2125870516 2778169.289420503 1.0 1.1670506604574218 1.0203236469769879 21.376676234708853 -10.765758108525446 2.868319565676538 0.980070112012037 1.0936871536272108 0.352163343368474 0.059901053305265003 44796137.6743987 26835077.561575152 6181769.596278785 0.021921542198047372 1.7149122059883635e-11 10.765758108525446 0.11361704161517383 ESVLTATSILNNPIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESVLTATSILNNPIVK 16 0 Q5BKZ1;A0A0A0MRN4;Q5BKZ1-3 Q5BKZ1 ZNF326 DBIRD complex subunit ZNF326 0 8708600.0 1529700.0 3256100.0 3922800.0 False True 2095271.428588136 3112234.7355172005 2996315.432602003 1.0 1.4853611293761249 1.430036887689067 20.998705716978204 -10.487591637709741 6.050669667791648 0.999636782942853 1.457699008532596 0.9891607517205334 0.022586027089951135 0.00011075020352526645 9.379039808751672e-06 0.0218856176538371 0.007289608898030828 3.2539311712680354e-11 10.487591637709741 0.4580622255897431 ESVNAK(ub)VLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESVNAKVLK 9 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 9853100.0 2178300.0 3485100.0 4189700.0 True False 2855772.394687208 2965136.6648134016 3756190.0344402543 1.0 1.038295863609317 1.3152974100555619 21.44544957035048 -6.93201978378907 0.7300142246621042 0.996087467571791 1.3752060056926525 0.9969207136445909 0.00779535703915118 0.09160220684939795 0.07263887316028833 0.007189309158429632 0.02479127969139644 1.1694461170243489e-07 6.93201978378907 0.3791185381208615 ESVNAK(ub)VLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESVNAKVLK 9 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 15674400.0 2757500.0 3889100.0 9027800.0 True False 2669964.671879189 5442037.911388579 6663148.351805321 1.0 2.0382434152427695 2.4955942009208787 21.348389222082737 -9.751417904097517 0.2150134004654432 5.073046997999434e-21 2.864522759299992 0.9993375084535644 0.016105788016156832 1.1971157256806926 0.09223765420529408 0.9903695892408463 0.24606016993700897 1.772483070908758e-10 9.751417904097517 2.864522759299992 ESVNAK(ub)VLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESVNAKVLK 9 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 8584100.0 2178300.0 2187700.0 4218100.0 True False 2983676.3763440796 2091040.1802435373 3221871.654496407 1.0 0.7008267373842012 1.0798328129822812 21.50865963187337 -6.696259040650526 1.843958178093805 0.8135497700476224 1.0786383324643962 0.39992653083544516 0.12637321803694326 0.4033738845511702 2.6637175173836978 0.05472677473998045 0.1414096230801008 2.0125234957108497e-07 6.696259040650526 0.2650885624167738 ESVNAK(ub)VLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESVNAKVLK 9 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 12394000.0 2757500.0 5488000.0 4148500.0 True False 2292983.427962709 5458435.054717286 5015932.169503213 1.0 2.3804947685849807 2.187513484979616 21.128794497517013 -10.178062762403199 4.516500286269343 0.9997510913094017 2.2840041268044327 0.983340470856313 0.07878427919972426 0.00019761088505672957 3.596246410680145e-05 0.07629681754407425 0.02542751676289904 6.63647155989088e-11 10.178062762403199 1.284253035495031 ESVNAK(ub)VLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESVNAKVLK 9 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 31770500.0 6521200.0 7764300.0 17485000.0 True False 8441821.952069726 7332209.8796317745 14302909.411250412 1.0 0.8685577498864564 1.694291764557258 23.00912297080944 -6.8661512357518975 1.1541835970555874 0.9271310037601856 1.7392568208206416 0.9606929091729286 0.07182367145048817 0.14060283893860823 0.3524756191418425 0.04839696851910679 0.11388257882954327 1.3609706647832324e-07 6.8661512357518975 0.812125817060456 ESVQGYTTK(ub)TK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESVQGYTTKTK 11 1 Q14694;Q14694-3;Q14694-2;H3BQP1;H3BNS8 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 1 4773650.0 1157300.0 889750.0 2726600.0 True False 1498147.6637935196 840234.6303468909 2230386.777278546 1.0 0.5608490075132508 1.4887629778969145 20.51474839827673 -6.7779912134538804 1.5436150283240557 0.7507016532575748 1.4956694039061627 0.7602858099245862 0.18556060318499834 0.25368545682272314 1.193786290700494 0.09469410406362436 0.22382410038393522 1.6672809442546148e-07 6.7779912134538804 0.7449677506485879 ESWHGK(ub)PLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESWHGKPLPK 10 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 33805400.0 14290200.0 17997100.0 1518100.0 True False 18734590.58649367 15312002.832146352 1361021.5746434708 1.0 0.8173118468457611 0.07264752161836256 24.159201114507912 -7.152161942611193 0.756747720544652 0.9966334278525448 2.5594209490845623e-23 0.9956216074965127 0.026540111676981854 0.08354196869240975 0.08419059945042595 0.023902850150505587 0.05732575966053951 7.044303473204398e-08 7.152161942611193 -0.9966334278525448 down ESWHGK(ub)PLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESWHGKPLPK 10 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 51578100.0 19732600.0 28552600.0 3292900.0 True False 19106199.414079145 39953802.07984197 2430390.705117501 1.0 2.0911433621068802 0.1272042991096687 24.187537491623225 -6.755912281031523 1.6278487395014567 1.6370224355842042 0.1214508887328805 0.6740241880736162 0.45870970229889824 0.28986024015776507 1.5128483539167634 0.22243717510163824 0.5367332309231382 1.7542347870862444e-07 6.755912281031523 -1.5155715468513238 ESWHGK(ub)PLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESWHGKPLPK 10 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 102176400.0 52505100.0 4485500.0 45185800.0 True False 79654075.33697487 3685027.47962854 36254806.82436028 1.0 0.0462628869149395 0.45515319424630934 26.247244840375625 -10.717113107827693 6.615069317808479 1.0100770791896423 0.25070804058062457 0.8174320934381086 0.16692876895527528 0.02456273303969263 0.0010503992428873663 0.1600263182623313 0.05387602851389059 1.9181691068851767e-11 10.717113107827693 -0.7593690386090177 ESWHGK(ub)PLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESWHGKPLPK 10 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 39288700.0 14290200.0 13292500.0 11706000.0 True False 19573673.11813441 12705193.397580666 8941283.892637663 1.0 0.6490960240778566 0.456801533298001 24.222411176030803 -11.025977386698923 0.10478758021018184 2.0058306698169157 1.145779570362344e-10 0.9998758091518525 0.002506177086038283 3.3589131637945107 0.06343817088748319 1.109584512601291 0.2977063174332445 9.419386410961441e-12 11.025977386698923 -2.0058306697023376 ESWHGK(ub)PLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESWHGKPLPK 10 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 67863200.0 19732600.0 36241700.0 11888900.0 True False 16408531.202399606 36046458.76868575 14374814.021937251 1.0 2.196812031744454 0.876057329240722 23.9679427670575 -6.668138040958275 1.9443101711284663 1.7651592770781743 0.8814778955647008 0.2706750221918319 0.5086024787960638 0.46541079974634314 3.3902726378970462 0.21074190409930688 0.5643509949704341 2.147147892438612e-07 6.668138040958275 -0.8836813815134735 ESWHGK(ub)PLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESWHGKPLPK 10 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 103273900.0 52505100.0 25096800.0 25672000.0 True False 67968886.98025152 23700141.018139776 20999959.416964293 1.0 0.3486910271905128 0.30896429748902415 26.018371162468075 -13.786019400477173 0.399594889586386 9.999999999998831 0.3065751034363803 0.9998334037516255 0.004089119427659277 22.335030883112037 0.20795758761954622 173.107996853296 0.010180125858065589 1.636743404421663e-14 13.786019400477173 -9.693424896562451 ESWHGKPLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESWHGKPLPK 10 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 10892500.0 521300.0 7011500.0 3359700.0 False True 683429.3482763804 5965411.530612932 3012070.47251806 1.0 8.728644073681929 4.407288741864172 19.382432676701608 -9.76752121391755 8.444558431727437 0.9998837949157556 6.567966407773065 0.6888189732444153 1.7641859279772145 0.0 0.0 1.7081656790908777 0.5693885596969591 1.7079642893460739e-10 9.76752121391755 5.568082612857309 ESWHGKPLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESWHGKPLPK 10 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 9473400.0 2896000.0 1072000.0 5505400.0 False True 2804068.0651902547 1500055.190406148 4063370.5815402446 1.0 0.5349567683566091 1.4490984124041035 21.419089938687197 -6.7684489580298415 1.58078858989577 0.7327311150887215 1.4538932669579454 0.7244495712656633 0.19591172759594488 0.26894446909879866 1.3261688248411316 0.09770883833071536 0.23288250372412145 1.7043196136381136e-07 6.7684489580298415 0.7211621518692239 ESWHGKPLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESWHGKPLPK 10 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 8432200.0 521300.0 3828500.0 4082400.0 False True 714038.6976027942 3659344.21084353 3118221.1996671776 1.0 5.124854189456203 4.367019897010937 19.4456427382245 -10.066823814568593 4.910634587087604 0.9999020361163311 4.745937043264945 0.9702177145035348 0.30938455445408375 53662746.03378934 12.785827321600916 59442.63772892422 0.10591056211996223 8.573856005471556e-11 10.066823814568593 3.746035007148614 ESYDYLK(ub)TLAGDVHIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESYDYLKTLAGDVHIVR 17 1 F8VXU5;Q9UBQ0;Q9UBQ0-2 F8VXU5 VPS29 Vacuolar protein sorting-associated protein 29 1 10161200.0 2561800.0 2608100.0 4991300.0 True False 2480477.0612584236 3649527.931061821 3683928.794209657 1.0 1.4713008187265 1.4851694666914939 21.242186184985833 -11.561071596616765 0.5620196913722905 7.757947865651469e-08 1.4838220124207464 0.9999308334847926 0.001875504190901374 4.70957868543551 0.27794204353814916 5.741362860853006 0.002544536141323347 2.7474411800238242e-12 11.561071596616765 1.4838219348412678 ESYDYNPNK(ub)TNRPFISQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESYDYNPNKTNRPFISQK 18 2 A0A5F9ZI63;O75530-3;O75530;O75530-2 A0A5F9ZI63 EED Polycomb protein EED 1 7724000.0 2562600.0 3529900.0 1631500.0 True False 2130915.4424287328 3510883.728069706 1972639.1067963084 1.0 1.6475941082242758 0.9257237840221256 21.023041915514202 -6.6702635178145 1.9363684482684562 1.4132718306461036 0.9286400097668049 0.28015516340087476 0.2750691526728092 0.4605707802955987 3.329575570418008 0.11434883769587412 0.3054143189436634 2.136665227049867e-07 6.6702635178145 -0.4846318208792987 ESYICK(ub)VNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESYICKVNR 9 1 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 10173400.0 1723100.0 2070100.0 6380200.0 True False 2614068.675483743 1700674.481234879 5119150.673458998 1.0 0.6505852341159946 1.9583076456519184 21.317865612706317 -6.835602582312648 1.3025989491168628 0.8138885286288872 1.9977247505570102 0.9166397477527645 0.15961384642630277 0.17399472463371837 0.5753616052944468 0.09614611008871649 0.22131624813479087 1.4601498147430498e-07 6.835602582312648 1.1838362219281229 ESYICK(ub)VNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESYICKVNR 9 1 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 3077200.0 1003600.0 0.0 2073600.0 True False 834537.8670184492 0.0 2507180.172756864 1.0 0.0 3.004273708650584 19.670617987560078 -6.816990829332348 1.3850287184480168 0.4593279617179985 3.065621826465913 0.8772799689760424 0.43758549812390607 0.19742287852570742 0.7449857194370402 0.2483347501202139 0.5728304303771828 1.5240849364048045e-07 6.816990829332348 2.6062938647479146 ESYICK(ub)VNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESYICKVNR 9 1 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 18901600.0 1723100.0 2590500.0 14588000.0 True False 2230586.917378911 2446336.3977674865 11933133.685520219 1.0 1.096723189178432 5.349773009312926 21.088991934798766 -6.911800324028122 0.883369397601908 0.8756956906419482 5.921142339390704 0.9915837548134838 0.18605710040600681 0.1032399527844814 0.13239290512125623 0.15369640819448438 0.42976423327707663 1.2251793716322872e-07 6.911800324028122 5.045446648748755 up ESYPVFYLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESYPVFYLFR 10 0 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 103232000.0 27638000.0 41654000.0 33940000.0 False True 36233685.64677271 35439385.566020295 30428214.37546895 1.0 0.978078407797216 0.8397769598185812 25.110828226665156 -6.934785156413426 0.7064416257359432 1.0017769492574788 0.8075870921693816 0.9973974478601738 0.003618492013198649 0.09022882929719696 0.06606645527697899 0.0033960392254310722 0.01220154223360026 1.1620233195459104e-07 6.934785156413426 -0.19418985708809722 ESYPVFYLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESYPVFYLFR 10 0 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 111343000.0 49250000.0 22214000.0 39879000.0 False True 47686585.70808706 31084166.04447962 29433493.555644214 1.0 0.6518429781230517 0.6172279503468971 25.507080155722456 -13.999999999999998 0.32631849371934235 4.706989792276971 0.6108302320174365 0.9997071489438025 0.00295813285261002 18.51734084430788 0.18248018982426167 47.02069315788851 0.011247483706893966 1.0000000000000041e-14 13.999999999999998 -4.096159560259535 ESYPVFYLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESYPVFYLFR 10 0 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 45007000.0 11056000.0 20584000.0 13367000.0 False True 16772760.301867705 16910624.376473926 10725006.591035776 1.0 1.008219522137383 0.6394300280939155 23.99961679772414 -6.901802532877704 0.949791878100396 1.0145838252657835 0.5992690573482566 0.9874422297525021 0.01926834159684254 0.11009094440871468 0.1700269381591719 0.015162001217303503 0.03981840312577005 1.253711088807057e-07 6.901802532877704 -0.41531476791752686 ESYPVFYLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESYPVFYLFR 10 0 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 185800000.0 27638000.0 60978000.0 97184000.0 False True 37856515.48886637 58283790.33271948 74231140.76730731 1.0 1.5395973343046006 1.9608550815813661 25.174038288188047 -6.973899659943972 0.13585333556859425 0.401015998856375 3.1103882309890354 0.9999990564252925 0.00038195831980793513 0.07505638818755844 0.004099002705454017 0.024876587371663504 0.05592601573003144 1.0619408812900416e-07 6.973899659943972 2.7093722321326603 ESYPVFYLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESYPVFYLFR 10 0 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 92017000.0 49250000.0 19579000.0 23188000.0 False True 40953557.144936875 19473524.04087278 28036503.59080159 1.0 0.47550262781703956 0.6845926348126213 25.287485431156732 -10.20319376288261 5.44387309558003 1.0000192969200965 0.5800476313147819 0.8432267003611764 0.08536063790919729 1.9992848779297465e-05 2.926362638216442e-06 0.08265387440009044 0.027550027420305025 6.263343597904854e-11 10.20319376288261 -0.4199716656053146 ESYPVFYLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESYPVFYLFR 10 0 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 53435000.0 11056000.0 23831000.0 18548000.0 False True 14312209.946341606 22504783.900867373 15172454.318551484 1.0 1.572418514348296 1.060105628371513 23.77074311981659 -10.283285869266217 3.7133216698009543 0.9993117939876646 1.3162620714711415 0.33692078731581954 0.2091508603142619 149400848.05502293 321438505.97767836 1243266.2560493124 0.07654137059262892 5.208517536650191e-11 10.283285869266217 0.3169502774834769 ESYSIYVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESYSIYVYK 9 0 Q16778 Q16778 HIST2H2BE Histone H2B type 2-E 0 1480390000.0 498740000.0 437930000.0 543720000.0 False True 653852969.8050299 372592551.03777003 487461070.13052344 1.0 0.5698414907389227 0.7455209238796877 29.284391016258404 -10.159810859972863 5.306142610565393 1.000011919755439 0.6576812073091669 0.8350494335417551 0.07172082824986215 1.011369656413176e-05 1.6013948159427813e-06 0.06944581019468506 0.02314779778225664 6.921323365409968e-11 10.159810859972863 -0.342330712446272 ESYSIYVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESYSIYVYK 9 0 Q16778 Q16778 HIST2H2BE Histone H2B type 2-E 0 1341220000.0 345050000.0 182890000.0 813280000.0 False True 334096576.62082094 255918930.75875032 600257570.122979 1.0 0.7660028526697613 1.7966588469544076 28.315689959019707 -6.84704414308419 1.2493784243846586 0.8753841979971487 1.8355454189634635 0.9358768323054487 0.11171528387239124 0.16073984779479877 0.4843365181027402 0.07002103603758143 0.1617459530455975 1.4221842244096467e-07 6.84704414308419 0.9601612209663147 ESYSIYVYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESYSIYVYK 9 0 Q16778 Q16778 HIST2H2BE Histone H2B type 2-E 0 1398180000.0 267770000.0 573210000.0 557200000.0 False True 406226666.6091829 470916196.9898288 447069175.770564 1.0 1.159244913487872 1.100541181853712 28.59770970705907 -10.114834153537155 4.238816452545153 0.9999773999068275 1.1298930476453695 0.8671623167751342 0.02396569814211906 2490900.1539802393 5958590.304785404 279.7032918820595 0.008204096789079528 7.676545819445609e-11 10.114834153537155 0.12991564773854192 ESYSIYVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESYSIYVYK 9 0 Q16778 Q16778 HIST2H2BE Histone H2B type 2-E 0 1443960000.0 498740000.0 534310000.0 410910000.0 False True 683137655.9417181 510702417.4731106 313861520.9570939 1.0 0.7475834673014734 0.4594411071139533 29.347601077781295 -6.969398254523801 0.2721738643811668 1.0697685939729646 0.12856827589206948 0.999977301151176 0.001052152527348122 0.07649845124093713 0.00972674363199402 0.0055740385535079165 0.026719536445406575 1.0730049994454098e-07 6.969398254523801 -0.9412003180808952 down ESYSIYVYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESYSIYVYK 9 0 Q16778 Q16778 HIST2H2BE Histone H2B type 2-E 0 817370000.0 345050000.0 247650000.0 224670000.0 False True 286924363.3068114 246315860.29532355 271647458.2432898 1.0 0.8584696588903302 0.9467563336641935 28.096095234453983 -10.305520940187161 4.981793363735751 1.0000337869339764 0.9026129962790104 0.6186658337662182 0.03604288404729875 1.3530289334510954e-05 1.8861941867738302e-06 0.03491047470513099 0.01163279080535416 4.948562500775866e-11 10.305520940187161 -0.097420790654966 ESYSIYVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESYSIYVYK 9 0 Q16778 Q16778 HIST2H2BE Histone H2B type 2-E 0 1619680000.0 267770000.0 765980000.0 585930000.0 False True 346633543.5358087 723352539.6494659 479296752.14949733 1.0 2.0867932522368267 1.3827189003708868 28.36883602915152 -10.147816166396126 4.870454713355546 0.9999480467910397 1.7347560763068604 0.5921815823380199 0.28743715051910373 0.0001621680163595343 2.8374770803951855e-05 0.27832940652239985 0.09276994141867129 7.115146287362298e-11 10.147816166396126 0.7348080295158207 ESYSVYVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESYSVYVYK 9 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 6376800000.0 1514500000.0 1936200000.0 2926100000.0 False True 1985524166.4388652 1647326507.2484863 2623335241.133166 1.0 0.8296683239081633 1.3212305775347202 30.88687277445042 -6.813132270526848 1.4013587664830853 0.9075077938445862 1.3304573269416087 0.8678348421249903 0.07409304669723628 0.2025645938653717 0.7834131327401838 0.041566892400856974 0.09602215640913367 1.5376862448844985e-07 6.813132270526848 0.42294953309702243 ESYSVYVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESYSVYVYK 9 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 4794800000.0 1284300000.0 604600000.0 2905900000.0 False True 1243530599.4902773 846019932.9473478 2144757614.8686364 1.0 0.6803370446164582 1.7247324800433312 30.21179486229679 -6.8245519572171185 1.3519589292745198 0.8284418851283037 1.7498544069827022 0.8945382678841233 0.14189299450255266 0.18764521789590524 0.672633908512852 0.08244445283460164 0.18984053400525802 1.4977800540406198e-07 6.8245519572171185 0.9214125218543985 ESYSVYVYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ESYSVYVYK 9 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 4636630000.0 971330000.0 2448600000.0 1216700000.0 False True 1473578623.7349112 2011628199.00088 976218711.7014446 1.0 1.3651312299185205 0.6624815913976376 30.45667689242329 -6.765481786228007 1.5917585203656914 1.2106359089234222 0.6591876101748656 0.7129766780500844 0.1537211233828739 0.27379950526407537 1.3683475294580507 0.07615434065395837 0.18203996614905343 1.7160036756780137e-07 6.765481786228007 -0.5514482987485566 ESYSVYVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESYSVYVYK 9 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 4951800000.0 1514500000.0 1810400000.0 1626900000.0 False True 2074451577.8235836 1730410541.8077896 1242659727.0572553 1.0 0.8341532578086274 0.5990304812807417 30.950082835973312 -6.9661781274771535 0.33722549875334634 1.0263361691940476 0.3990665666139636 0.9999354062312085 0.0013221381525205006 0.07756346069547387 0.013462926380221917 0.0033480111249934883 0.02039282858416877 1.080990488140354e-07 6.9661781274771535 -0.6272696025800839 ESYSVYVYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESYSVYVYK 9 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 3215010000.0 1284300000.0 1174700000.0 756010000.0 False True 1067952354.1369011 1168371657.9403064 914088195.604707 1.0 1.0940297602364126 0.8559260083690304 29.992200137731068 -6.799546466211297 1.4576081963186633 1.0519094262659607 0.8526696389518896 0.830893385369888 0.040266611127720224 0.2213945966480816 0.9286682135102071 0.021732454769017105 0.050559207328742445 1.5865491611592048e-07 6.799546466211297 -0.1992397873140711 ESYSVYVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ESYSVYVYK 9 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 4341630000.0 971330000.0 2305100000.0 1065200000.0 False True 1257405832.7767735 2176819158.65425 871344529.8749758 1.0 1.7311985533319056 0.692970007901709 30.22780321451574 -6.717476168109216 1.768681914057123 1.4460523881800307 0.694843014654572 0.5004729641196068 0.30778985499949857 0.3602330542877395 2.200982526542059 0.1382593557234071 0.34807984514869184 1.916566231338291e-07 6.717476168109216 -0.7512093735254587 ESYSVYVYK(ub)VLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ESYSVYVYKVLK 12 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 17388800.0 5247000.0 5078500.0 7063300.0 True False 6878867.812020272 4320807.595837952 6332457.47195786 1.0 0.6281277259446221 0.9205668207335509 22.713739701635767 -10.465479475792815 6.140463180031301 1.0001178232773407 0.7743472733391759 0.4425458076885894 0.11938776051237983 0.0001926749467976661 1.6772095685142672e-05 0.11565673880460686 0.03853223401712052 3.423895681414713e-11 10.465479475792815 -0.2257705499381648 ESYSVYVYK(ub)VLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ESYSVYVYKVLK 12 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 18896400.0 6995000.0 6527300.0 5374100.0 True False 6772947.553869416 9133684.929419821 3966461.990455819 1.0 1.3485539134585067 0.5856330584148346 22.691352393656107 -6.782453118258301 1.526024241224218 1.1967264697849063 0.5790852577421467 0.7760898717146275 0.14756341686986302 0.24676852279042513 1.1351578316446225 0.07614526738848083 0.17932775969066347 1.6502391336990115e-07 6.782453118258301 -0.6176412120427596 ESYSVYVYK(ub)VLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ESYSVYVYKVLK 12 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 15769000.0 5247000.0 4619400.0 5902600.0 True False 7186957.694843393 4415299.6336869765 4508527.4478628915 1.0 0.614348911063569 0.6273207161213343 22.776949763158658 -9.921490994064772 5.634578807327636 1.0000003176028889 0.6208348136015323 0.9991229494380238 0.0052957172413697 2.112804361152979e-08 4.0545344391172035e-09 0.00512756044818413 0.001709185389835223 1.1981439687626735e-10 9.921490994064772 -0.3791655040013566 ESYSVYVYK(ub)VLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ESYSVYVYKVLK 12 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 18942600.0 6995000.0 7721600.0 4226000.0 True False 5816652.4310423 7680002.208182402 5109637.061183701 1.0 1.320347450570672 0.8784497822002566 22.471757669090383 -6.7122631645675295 1.786978560033629 1.1964900196693393 0.87941228158067 0.4758192289594415 0.13494684566846749 0.37059565425449775 2.308210960233098 0.06006182455717545 0.15217705579271062 1.9397101369568375e-07 6.7122631645675295 -0.31707773808866935 ETAAVIFLHGLGDTGHSWADALSTIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETAAVIFLHGLGDTGHSWADALSTIR 26 0 O95372;Q5QPQ3;Q5QPQ2;Q5QPN5;Q5QPN9 O95372 LYPLA2 Acyl-protein thioesterase 2 0 116162000.0 13049000.0 62143000.0 40970000.0 False True 19796287.009684525 51053096.12452485 32872261.542211052 1.0 2.578922810098136 1.6605266192660089 24.238726528100464 -10.389031637894066 7.30129631455175 0.9999612519212345 2.1197247146820724 0.664653294264991 0.37493367487573964 0.0002364944815631574 1.9790087904662175e-05 0.36304037595042055 0.12100932322717384 4.082896417803323e-11 10.389031637894066 1.119763462760838 ETAAVIFLHGLGDTGHSWADALSTIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETAAVIFLHGLGDTGHSWADALSTIR 26 0 O95372;Q5QPQ3;Q5QPQ2;Q5QPN5;Q5QPN9 O95372 LYPLA2 Acyl-protein thioesterase 2 0 52594000.0 13049000.0 25328000.0 14217000.0 False True 16892187.73424493 23918474.534898616 11629651.878738757 1.0 1.4159488937249698 0.6884633335658695 24.009852850192914 -6.751603883895979 1.6437004671113955 1.2441036890987216 0.6868187861241801 0.6559542109794203 0.17480055688244803 0.29724254297761804 1.5804930626439404 0.08398810911375516 0.2035749466462091 1.771724195341052e-07 6.751603883895979 -0.5572849029745415 ETAEAYLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETAEAYLGK 9 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 61952000.0 10508000.0 23374000.0 28070000.0 False True 13776089.759616757 19886690.311138377 25165585.66645295 1.0 1.4435656748865153 1.826758253290667 23.71566311212659 -6.972833285107545 0.17793458562458556 0.6955384015922846 2.5851265923286793 0.9999968826773452 0.0005964294516254983 0.07539359356818254 0.005598505272170013 0.015029475880382693 0.043276186720400706 1.0645515947822812e-07 6.972833285107545 1.8895881907363945 ETAEAYLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETAEAYLGK 9 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 54036600.0 12534000.0 3660600.0 37842000.0 False True 12136115.030764721 5122296.66977681 27930044.964334268 1.0 0.42207054372770264 2.3013991622139676 23.532803329392255 -6.8241552856581045 1.353896141134082 0.6897429433776263 2.346168010456678 0.8936542205169747 0.256305223004701 0.1881376937805331 0.6764866694174626 0.14872245935470135 0.34244479330697697 1.4991487063842973e-07 6.8241552856581045 1.656425067079052 up ETAEAYLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETAEAYLGK 9 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 47399000.0 10508000.0 14329000.0 22562000.0 False True 14393091.568022579 13695897.400333535 17233320.278975815 1.0 0.9515604993969458 1.197332775764689 23.778873173649483 -6.85552804685136 1.2081507395601399 0.9739718494477775 1.2082551665248773 0.9479636090870789 0.024247823831507948 0.15148274333314576 0.4227256564964059 0.015679794434695547 0.036435617231850376 1.394671586475371e-07 6.85552804685136 0.23428331707709982 ETAEAYLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETAEAYLGK 9 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 22492100.0 12534000.0 6437500.0 3520600.0 False True 10422576.350347985 6402819.909756289 4256741.182584795 1.0 0.6143221881548043 0.40841544734212215 23.31320860482653 -10.682064101589567 0.11998886669695488 1.9153907353487891 2.9367003511107545e-18 0.9998309488482235 0.0031881062524897934 2.6725938916211125 0.06657847096175337 0.9540945760394308 0.2565122448676612 2.079389747846747e-11 10.682064101589567 -1.9153907353487891 ETAEAYLGK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETAEAYLGKK 10 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 4605670.0 741370.0 556100.0 3308200.0 True False 717835.6151554213 778153.630023189 2441683.1761273392 1.0 1.084027615228743 3.401451703672687 19.453293978161213 -6.914577816104108 0.8639738159550714 0.9382133606236063 3.7322322178484555 0.9925375801707567 0.0961277090484967 0.10146819770242878 0.12292096467026165 0.08052774752364328 0.23001972169653837 1.217368847341977e-07 6.914577816104108 2.794018857224849 up ETAEAYLGK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETAEAYLGKK 10 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 3635570.0 741370.0 1151200.0 1743000.0 True False 616482.003259733 1144998.2571046916 2107453.241278559 1.0 1.8573101097037004 3.418515431326643 19.23369925359549 -6.961835752618652 0.4087399949766514 0.9220290871305181 4.411615616820106 0.9998323399915013 0.012963857684467341 0.07905176329246871 0.018755522881460335 0.020097028496063107 0.13040260532298611 1.0918531902324686e-07 6.961835752618652 3.4895865296895883 ETALLIDPK(ub)NSCSSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETALLIDPKNSCSSSR 16 1 E9PLK3;P55786;P55786-2;A6NEC2;A6NEC2-2;E9PI82;E9PJ74 E9PLK3 NPEPPS;NPEPPSL1 Puromycin-sensitive aminopeptidase;Puromycin-sensitive aminopeptidase-like protein 1 5432280.0 834480.0 1552500.0 3045300.0 True False 1094011.361115816 1320873.0515976006 2730201.568580305 1.0 1.2073668506060131 2.4955879487354573 20.06119628966702 -6.9351040802512784 0.7036410664776199 0.9836180442705205 2.798058759481585 0.9974496554888719 0.03341085407597166 0.09007284467621261 0.06532401596125123 0.03142286603966339 0.1134694915957994 1.1611703018086673e-07 6.9351040802512784 1.8144407152110644 up ETALLIDPK(ub)NSCSSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETALLIDPKNSCSSSR 16 1 E9PLK3;P55786;P55786-2;A6NEC2;A6NEC2-2;E9PI82;E9PJ74 E9PLK3 NPEPPS;NPEPPSL1 Puromycin-sensitive aminopeptidase;Puromycin-sensitive aminopeptidase-like protein 1 6902880.0 834480.0 1349700.0 4718700.0 True False 1143009.8069740662 1290065.7911389598 3604240.244677034 1.0 1.1286568000271149 3.1532889942726547 20.12440635118991 -6.919850540529901 0.8258337247717621 0.955086579856612 3.4786602348162305 0.9941393037090183 0.07549452929277423 0.09825988237344713 0.10607036562066419 0.06499476079097136 0.1944131543112272 1.2026782568874631e-07 6.919850540529901 2.5235736549596184 up ETCAWFTDNYEQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETCAWFTDNYEQAR 14 0 Q13630 Q13630 TSTA3 GDP-L-fucose synthase 0 6034000.0 1123700.0 2704400.0 2205900.0 False True 1473181.5819262788 2300914.061668636 1977654.6284869479 1.0 1.5618672469825778 1.3424377909348 20.490503834863627 -10.158107725315196 4.660837918072545 0.9999472880818123 1.4521525189611793 0.8498799228478195 0.0895817003275544 5.0152970504354686e-05 9.059006488725683e-06 0.0867474131297396 0.028912369455139357 6.948519404766594e-11 10.158107725315196 0.4522052308793669 ETCSLWPGQALSLQVEQLLHHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETCSLWPGQALSLQVEQLLHHR 22 0 P19623;K7EKM4 P19623 SRM Spermidine synthase 0 205434000.0 121960000.0 28039000.0 55435000.0 False True 118088446.55752872 39235118.92145331 40914910.485647425 1.0 0.3322519693096249 0.34647682883790887 26.8152925815011 -9.915821437556563 5.746653898017473 1.0000003886538724 0.3393643991395549 0.9996523976286771 0.0058072745871488194 2.891544883088969e-08 5.452996125837513e-09 0.005622872790904605 0.00187428981318881 1.2138878442001642e-10 9.915821437556563 -0.6606359895143175 ETCSLWPGQALSLQVEQLLHHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETCSLWPGQALSLQVEQLLHHR 22 0 P19623;K7EKM4 P19623 SRM Spermidine synthase 0 70640000.0 17230000.0 30634000.0 22776000.0 False True 26139169.681727666 25167123.355465528 18274313.61692458 1.0 0.9628126547974614 0.6991160713761716 24.639709978448195 -6.932411231183237 0.7267258539796422 1.0036731777240993 0.6414989835250251 0.9969912944127493 0.0073466167049095355 0.0914050506488955 0.07168707940118177 0.006791814300076275 0.023551632222571898 1.1683925222637537e-07 6.932411231183237 -0.36217419419907415 ETCSLWPGQALSLQVEQLLHHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETCSLWPGQALSLQVEQLLHHR 22 0 P19623;K7EKM4 P19623 SRM Spermidine synthase 0 41645100.0 17230000.0 14863000.0 9552100.0 False True 22304574.654076185 14035860.984372946 7813715.812822719 1.0 0.6292817147180109 0.350318978685153 24.410836300540645 -7.8294794085882895 0.21027115231486906 1.2149846213691262 2.5974369841823516e-16 0.999856276880695 0.003190260527912433 0.12232403942577072 0.031150361153936226 0.05833533020977571 0.09112275274833453 1.4808824673907636e-08 7.8294794085882895 -1.214984621369126 down ETCVVVYTGYGNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETCVVVYTGYGNR 13 0 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;Q16637-4;Q16637-2;A0A0G2JRX5;A0A0G2JRY6;A0A0G2JQN8 A0A1W2PRV5 SMN1 Survival motor neuron protein 0 19344700.0 7970200.0 5615600.0 5758900.0 False True 10449009.383526586 4777774.369437357 5163024.271269541 1.0 0.45724663401774435 0.4941161484082234 23.316862838554346 -10.122604572709303 5.686283045994163 1.0000053762116192 0.4756813912129323 0.9963051399792919 0.015051916220328157 1.0259013149660077e-06 1.5830787269931512e-07 0.01457410466001759 0.004857985070793485 7.54041810097874e-11 10.122604572709303 -0.5243239849986869 ETCVVVYTGYGNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETCVVVYTGYGNR 13 0 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;Q16637-4;Q16637-2;A0A0G2JRX5;A0A0G2JRY6;A0A0G2JQN8 A0A1W2PRV5 SMN1 Survival motor neuron protein 0 34958300.0 6572300.0 15663000.0 12723000.0 False True 9970659.599490345 12867815.274422418 10208293.473311 1.0 1.2905681059536085 1.023833315283655 23.249257517221153 -10.560607973779678 3.3419885656876427 0.9946658049531261 1.1572007106890567 0.31652650519002556 0.1088940226742933 39628237.30771995 8815.299624069872 1630021.5790190762 0.03727731286933676 2.7503757248262043e-11 10.560607973779678 0.16253490573593066 ETCVVVYTGYGNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETCVVVYTGYGNR 13 0 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;Q16637-4;Q16637-2;A0A0G2JRX5;A0A0G2JRY6;A0A0G2JQN8 A0A1W2PRV5 SMN1 Survival motor neuron protein 0 19992400.0 7970200.0 4034400.0 7987800.0 False True 10916998.326556286 3856146.86802328 6101246.153904935 1.0 0.353224096283221 0.5588757982185698 23.380072900077238 -10.192204265560362 5.160870438158754 1.0000368662810881 0.4560499472506225 0.9031765631243126 0.08395695574716859 3.56156849809764e-05 5.574514150473614e-06 0.0812964673967501 0.02709699095043304 6.423855074013384e-11 10.192204265560362 -0.5439869190304656 ETCVVVYTGYGNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETCVVVYTGYGNR 13 0 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;Q16637-4;Q16637-2;A0A0G2JRX5;A0A0G2JRY6;A0A0G2JQN8 A0A1W2PRV5 SMN1 Survival motor neuron protein 0 26107900.0 6572300.0 12150000.0 7385600.0 False True 8507971.909401324 11473841.819291642 6041496.582655484 1.0 1.3485989306820614 0.710098322724787 23.020383839313602 -6.758466715696476 1.618306951051623 1.2028747789982257 0.7079472584286247 0.6846286771310002 0.14659111230420013 0.2855132129456581 1.4733707816022195 0.0714836066850779 0.1720430061595915 1.7439470083403207e-07 6.758466715696476 -0.494927520569601 ETDLLILFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETDLLILFK 9 0 P05455 P05455 SSB Lupus La protein 0 7087600.0 1563400.0 2792200.0 2732000.0 False True 2049632.5399871387 2375614.6439103526 2449318.847194496 1.0 1.1590441689246695 1.1950038845547726 20.96693385453939 -13.999999999999996 0.2089070413480439 0.0842977935261701 1.216409911611961 0.9994894228701522 0.00191457769485249 12.721258822946037 0.14487660970701943 4.7788505061940505 0.02146487405303069 1.0000000000000082e-14 13.999999999999996 1.132112118085791 ETDLLILFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETDLLILFK 9 0 P05455 P05455 SSB Lupus La protein 0 16681200.0 8145100.0 2876300.0 5659800.0 False True 7886538.258902335 4024821.589706347 4177328.589639537 1.0 0.510340717001293 0.5296783522129197 22.910960747554437 -10.486464628864903 9.556077300377746 1.0000059408543984 0.5200095346188041 0.9987841649764897 0.007894556516760394 9.99218505067571e-07 5.3710075176304445e-08 0.007643965887579395 0.002547957159592192 3.262386198324585e-11 10.486464628864903 -0.47999640623559436 ETDLLILFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETDLLILFK 9 0 P05455 P05455 SSB Lupus La protein 0 17890700.0 2344900.0 11886000.0 3659800.0 False True 3557384.7351528257 9764850.434258124 2936438.925852679 1.0 2.7449520255049458 0.8254487901844919 21.76238558125023 -6.66739784444872 1.9464436929056934 2.1162628411000837 0.8332619153006403 0.26764829030058 0.7416621376590555 0.4671120826397823 3.4092609732773953 0.30701772751685713 0.8231139168174033 2.1508105374761243e-07 6.66739784444872 -1.2830009257994432 ETDLLILFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETDLLILFK 9 0 P05455 P05455 SSB Lupus La protein 0 7501400.0 1563400.0 3139400.0 2798600.0 False True 2141431.229296395 3000690.9273924967 2137628.3189762337 1.0 1.4012548646628389 0.9982241268044779 21.030143916062283 -10.23558291380397 14.229614385980817 0.9999982554344683 1.1997394925959646 0.2466953413185452 0.1645366097381481 0.0 0.0 0.15931188733792617 0.05310396244597538 5.813224379071679e-11 10.23558291380397 0.19974123716149628 ETDLLILFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETDLLILFK 9 0 P05455 P05455 SSB Lupus La protein 0 11943500.0 8145100.0 1442000.0 2356400.0 False True 6773011.539111176 1434231.6597854118 2849112.345237403 1.0 0.2117568605196303 0.4206566501156874 22.691366022988714 -10.224752649266875 6.103583647320134 1.0000126805401384 0.3162067553247011 0.9345809007664251 0.08528298198085836 1.4716201071893577e-05 1.8690714192281426e-06 0.08257642027176117 0.027524964077229885 5.960014972158413e-11 10.224752649266875 -0.6838059252154373 ETDLLILFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETDLLILFK 9 0 P05455 P05455 SSB Lupus La protein 0 10466400.0 2344900.0 5424500.0 2697000.0 False True 3035519.274889334 5122621.806481272 2206173.6735568973 1.0 1.6875602961434093 0.7267862509742514 21.533511903342678 -6.71458551952312 1.77865654420344 1.4207007209463298 0.7287062181887873 0.48691257022908774 0.2895361298444617 0.3659479597307405 2.2594373887574486 0.12940117294456788 0.32694974607624466 1.9293653759087157e-07 6.71458551952312 -0.6919945027575425 ETDLQELFRPFGSISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETDLQELFRPFGSISR 16 1 O75821;K7ENA8;K7EP16 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 8641200.0 1827400.0 4240700.0 2573100.0 False True 2395739.0965667735 3608004.090119129 2306860.294918064 1.0 1.5060087700240807 0.9629013018253625 21.19203937203171 -6.66208253887073 1.9656429148467636 1.3251519110762136 0.9651622748239039 0.24447397282588346 0.2153402186919615 0.4795002767097924 3.563691067229532 0.088445230724761 0.23875272827393393 2.1772959318984116e-07 6.66208253887073 -0.3599896362523096 ETDLQELFRPFGSISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETDLQELFRPFGSISR 16 1 O75821;K7ENA8;K7EP16 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 16353900.0 1827400.0 3578500.0 10948000.0 False True 2503039.1636281363 3420390.037482969 8362307.881137624 1.0 1.3664948144579327 3.340861782209002 21.255249433554603 -6.938155934496728 0.6764996100479093 0.9769724816571868 3.8455963851111186 0.997912280445526 0.04697345514127058 0.08861803833553074 0.0585163694267359 0.04510992795280251 0.17135630170649482 1.1530391819475486e-07 6.938155934496728 2.8686239034539316 up ETDSSSASAATPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETDSSSASAATPSK 14 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 3834240.0 1307400.0 460140.0 2066700.0 False True 1265897.3026345791 643876.3015984003 1525369.270328993 1.0 0.5086323355444143 1.2049707880365983 20.271728938553693 -6.717127510044167 1.7699135226827054 0.7001422276782577 1.2036958802812594 0.4988375364366777 0.20684518982081196 0.36091403427909663 2.208015733621122 0.09285695034196433 0.23387382338600746 1.9181054969849847e-07 6.717127510044167 0.5035536526030017 ETDSSSASAATPSK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETDSSSASAATPSKK 15 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 28754300.0 5875100.0 5606200.0 17273000.0 True False 8047283.23860767 5358499.546775751 13193473.148601612 1.0 0.6658768416485948 1.6394940699122613 22.94007038115792 -6.8140677727057035 1.3973877332863855 0.8187625633416049 1.658155570303671 0.8701817489980069 0.14554147439429002 0.2013033232305927 0.7739258061426549 0.08187814698421128 0.18907448318698747 1.534377520787293e-07 6.8140677727057035 0.8393930069620661 ETDSSSASAATPSKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETDSSSASAATPSKK 15 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 4241930.0 1033000.0 755930.0 2453000.0 True False 1354273.0035862303 643148.1905920607 2199187.090837515 1.0 0.47490291018793807 1.6238875655158747 20.36908716585802 -6.7824647213631115 1.5264324583511808 0.7036272724190615 1.6336756665189025 0.7759594691192564 0.22229840237925383 0.24676472864912788 1.135820117031179 0.11468931442655785 0.2700477659250232 1.6501950446243351e-07 6.7824647213631115 0.930048394099841 ETDSSSASAATPSKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETDSSSASAATPSKK 15 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 11442000.0 1454800.0 7862400.0 2124800.0 True False 1408618.1703172585 11001897.32187435 1568251.1373663535 1.0 7.810418432552542 1.113325932046682 20.425849167172245 -6.642267892240906 2.03607627599891 5.445910371245481 1.1411777385136415 0.16341703749566627 2.9123222810277043 0.5276830580621698 4.183594918279517 1.1636348700848704 3.2253508410119798 2.2789358888666017e-07 6.642267892240906 -4.30473263273184 ETDSSSASAATPSKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETDSSSASAATPSKK 15 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 17699150.0 4999550.0 10084400.0 2615200.0 True False 7584682.866063927 8284760.030223177 2098304.57371712 1.0 1.0923014418034007 0.2766502714445114 22.854657428488387 -6.878770043844431 1.0866016214382093 1.0563317721379377 0.2201840309324168 0.9726812305016048 0.060278697926795737 0.1287267585959745 0.2788979914861442 0.042778463349983475 0.10313659937029154 1.3219954370437586e-07 6.878770043844431 -0.8361477412055209 down ETDSSSASAATPSKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETDSSSASAATPSKK 15 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 4769560.0 1033000.0 832560.0 2904000.0 True False 1414928.0157753448 795774.7462922521 2218135.0097573726 1.0 0.5624135909530265 1.5676663300372145 20.43229722738091 -6.788385656901062 1.502667473524562 0.7549170407048976 1.5779027170899849 0.7960763285054425 0.18584123889832035 0.23777176035628972 1.0606550342410854 0.09735287924255975 0.22820854000876803 1.6278498472101023e-07 6.788385656901062 0.8229856763850872 ETDSSSASAATPSKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETDSSSASAATPSKK 15 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 13241200.0 1454800.0 10158500.0 1627900.0 True False 1209730.658567596 10103774.144195637 1968286.3634408284 1.0 8.352085708201525 1.6270451190940423 20.20625444260652 -6.62495423359834 2.098466034434558 5.861346314240113 1.6533873383981346 0.09965792274095686 3.157695439420155 0.572328742010677 4.795755445735721 1.23347977994109 3.4999612099917146 2.3716236166429954e-07 6.62495423359834 -4.207958975841978 ETDSSSASAATPSKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETDSSSASAATPSKK 15 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 18586550.0 4999550.0 1435400.0 12151600.0 True False 6472016.030863988 1355518.7281819931 9940133.485945135 1.0 0.20944304243341572 1.535863545229533 22.625783750580837 -6.745202383469048 1.6671924697186256 0.5325097756814798 1.537644732217732 0.6283393960479886 0.33214776731968504 0.3084373616642183 1.6851034013630388 0.15747303946842112 0.3843085778686756 1.7980328272939378e-07 6.745202383469048 1.0051349565362522 ETEELMAWMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETEELMAWMR 10 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 4144450.0 726550.0 1508800.0 1909100.0 False True 952514.0859202088 1283692.9212563362 1711564.6453803114 1.0 1.3476891735581848 1.7968916897714913 19.861380901989723 -6.967619358621638 0.30981942400194307 0.9306488926883522 2.228207078267801 0.9999574077471026 0.002128917302221632 0.07708298506265825 0.011781189434742788 0.0071130913709200865 0.03988759474764223 1.0774091050113116e-07 6.967619358621638 1.2975581855794487 ETEELMAWMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETEELMAWMR 10 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 3796050.0 726550.0 1254100.0 1815400.0 False True 995175.1692754859 1198689.715245885 1386639.909336614 1.0 1.2045012297870767 1.3933626482522918 19.924590963512614 -6.972079445699745 0.2024494353303912 0.8910775071743768 1.7120147282575562 0.9999943806655497 0.0003807364005732344 0.07563357493152432 0.006556638880229591 0.006009877736071434 0.019927448166393448 1.0664010261306033e-07 6.972079445699745 0.8209372210831793 ETEGDVTSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETEGDVTSVK 10 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 8551500.0 2341200.0 1076200.0 5134100.0 False True 2266879.8875080897 1505932.2723088574 3789325.190301483 1.0 0.6643193936332823 1.6716038689050128 21.112276520046812 -6.816867330355582 1.3854580916264294 0.818480469481302 1.69213696895223 0.877012891914421 0.14686250042446022 0.19757992704830882 0.746055430164025 0.08331926212338972 0.19220849921643846 1.5245183973459805e-07 6.816867330355582 0.873656499470928 ETEGDVTSVK(ub)DAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETEGDVTSVKDAK 13 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 145624000.0 58417000.0 70099000.0 17108000.0 True False 76585252.71103275 59640502.44376191 15337828.271523945 1.0 0.778746564548062 0.20027130196195594 26.190563277132387 -7.050727248164667 0.5432927331002559 1.0070503762888134 3.89215053252806e-14 0.9993613534464388 0.008520776226161462 0.07434736949901373 0.03291222059660703 0.0094854136446305 0.042786449065607635 8.897597420677885e-08 7.050727248164667 -1.0070503762887746 down ETEGDVTSVK(ub)DAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETEGDVTSVKDAK 13 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 127850240.0 35834640.0 71558000.0 20457600.0 True False 34697088.968090214 100131482.57004037 15099140.845155241 1.0 2.8858756036314186 0.4351702489808707 25.048311292217647 -6.70113546067683 1.8265692058486527 2.1697297370001287 0.44224252552065907 0.4230740168119015 0.7958854911152214 0.3931704282767836 2.550966078348028 0.3474909304965983 0.8924878283276468 1.9900525254171737e-07 6.70113546067683 -1.7274872114794697 ETEGDVTSVK(ub)DAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETEGDVTSVKDAK 13 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 120126200.0 58417000.0 47005000.0 14704200.0 True False 80015343.56006615 44928163.67525138 11231370.802504921 1.0 0.5614943544112209 0.1403652137552059 26.25377333865528 -7.788666444810465 0.4073633932433851 1.0470230163062024 2.3149333593591674e-18 0.9978629730433659 0.016224559049451973 0.11383676096685054 0.07303603796454346 0.03303595801255192 0.07843136653666839 1.626797720493526e-08 7.788666444810465 -1.0470230163062024 down ETEHCVSLSLAQLSATIFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETEHCVSLSLAQLSATIFR 19 0 Q8TEX9;Q8TEX9-2;H0YN14 Q8TEX9 IPO4 Importin-4 0 27512000.0 6968300.0 11773000.0 8770700.0 False True 10571420.550968245 9672016.167131156 7037167.300665629 1.0 0.9149211423856644 0.6656784929458784 23.33366591833364 -6.951983544820375 0.5366244413961018 1.003753204620792 0.5654027265021403 0.9993478995942616 0.0036226972213917355 0.08269886652300426 0.03274047374652793 0.004003288332801688 0.020630073984799446 1.1169055659179054e-07 6.951983544820375 -0.4383504781186517 ETEHCVSLSLAQLSATIFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETEHCVSLSLAQLSATIFR 19 0 Q8TEX9;Q8TEX9-2;H0YN14 Q8TEX9 IPO4 Importin-4 0 13805300.0 6968300.0 3934000.0 2903000.0 False True 9020601.715728326 3715069.4417360667 2374683.7872953936 1.0 0.41184275271332177 0.26325115132340826 23.10479224042609 -13.999999999999767 0.19319290755870114 4.188436647138845 0.16000818069535863 0.9994879678519194 0.007198474429218866 12.404469790580853 0.139386947392165 14.90530590026641 0.09965279811689745 1.0000000000005358e-14 13.999999999999767 -4.028428466443486 ETEQLEIK(ub)EVHIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETEQLEIKEVHIEK 14 1 Q9BPX3;H0Y9Z8 Q9BPX3 NCAPG Condensin complex subunit 3 1 3339870.0 1443700.0 1120000.0 776170.0 True False 1200500.516754219 1113966.3376974054 938463.5583953975 1.0 0.9279182492226031 0.78172690915012 20.19520459389924 -6.959770729744248 0.4386535577975396 1.0053011699819052 0.6986569290055257 0.9997615960904368 0.0014020561017610157 0.07978312618580838 0.02143474518184171 0.0019242711465179772 0.01211599979664858 1.0970571954506919e-07 6.959770729744248 -0.30664424097637955 ETFASTASQLHSNVVNYVQQIVAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETFASTASQLHSNVVNYVQQIVAPK 25 0 A6NKB8;Q9H4A4 A6NKB8 RNPEP Aminopeptidase B 0 82206000.0 42611000.0 9993000.0 29602000.0 False True 41258337.12908217 13983257.012806563 21848348.159035552 1.0 0.3389195490127993 0.5295498965622415 25.29818234040513 -10.391104699692885 5.185268731678633 1.0003938678463713 0.4342347227875455 0.92153356469527 0.07782451349768417 0.0003545949098351547 4.163929974765962e-05 0.07540403129920635 0.02511775372525546 4.0634535563709616e-11 10.391104699692885 -0.5661591450588258 ETFASTASQLHSNVVNYVQQIVAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETFASTASQLHSNVVNYVQQIVAPK 25 0 A6NKB8;Q9H4A4 A6NKB8 RNPEP Aminopeptidase B 0 104378000.0 31068000.0 26474000.0 46836000.0 False True 47132427.37503858 21749507.857693892 37578844.07105191 1.0 0.46145528819533005 0.7973033888543949 25.49021664795715 -10.637461369927992 5.134425122044106 1.0050992015217648 0.6293793385248763 0.6188623424930545 0.137109412949603 0.008083857018021761 0.0005707957878793742 0.1340937526300879 0.04425187274684003 2.3042979320015444e-11 10.637461369927992 -0.37571986299688853 ETFASTASQLHSNVVNYVQQIVAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETFASTASQLHSNVVNYVQQIVAPK 25 0 A6NKB8;Q9H4A4 A6NKB8 RNPEP Aminopeptidase B 0 115606000.0 42611000.0 19570000.0 53425000.0 False True 35432934.48736862 19464572.52565913 64595920.49070965 1.0 0.5493356056241403 1.823047439487047 25.078587615839407 -6.8110824533572005 1.410111015635638 0.7547069354084078 1.845858306360309 0.8626029674131691 0.19547201973387912 0.20532881042199091 0.8044959524338429 0.10899593918913376 0.2519929263397382 1.544961091758416e-07 6.8110824533572005 1.0911513709519012 ETFASTASQLHSNVVNYVQQIVAPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETFASTASQLHSNVVNYVQQIVAPK 25 0 A6NKB8;Q9H4A4 A6NKB8 RNPEP Aminopeptidase B 0 69464000.0 31068000.0 15408000.0 22988000.0 False True 40218138.44183625 14550531.255279467 18804419.876798667 1.0 0.36179027222561644 0.4675606730031463 25.2613429700496 -10.278386811576492 7.26727180250482 1.0000033360874752 0.4146754726159831 0.9760950287499395 0.043180585299104214 2.334009822875454e-06 2.3181125297833663e-07 0.04180966041721226 0.013936473978576613 5.267604844708469e-11 10.278386811576492 -0.585327863471492 ETFGVNNAVYGIDAMNPSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETFGVNNAVYGIDAMNPSSR 20 0 O75822-3;O75822;H0YGJ7 O75822-3 EIF3J Eukaryotic translation initiation factor 3 subunit J 0 6103700.0 923900.0 2514500.0 2665300.0 False True 1211241.8470603258 2139346.4014442316 2389520.323362917 1.0 1.7662421477894015 1.9727854756358227 20.20805552413256 -10.892648680623303 0.25661543321593233 4.380887246901771e-14 2.068010635268749 0.9992082087754621 0.011775402163378008 2.764401795589957 0.1338868473179312 1.7526341166345307 0.09110861348484676 1.2804166691194045e-11 10.892648680623303 2.068010635268705 ETFGVNNAVYGIDAMNPSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETFGVNNAVYGIDAMNPSSR 20 0 O75822-3;O75822;H0YGJ7 O75822-3 EIF3J Eukaryotic translation initiation factor 3 subunit J 0 5965500.0 923900.0 2084000.0 2957600.0 False True 1265490.797458702 1991921.9891335808 2259075.793684023 1.0 1.5740311925884116 1.7851380651843465 20.271265585655453 -11.084337136569852 0.19122147262739167 5.959797727299462e-22 1.9655821857011881 0.9994210185547618 0.007982565929886307 3.261904737378006 0.10850743097600522 1.5611112200380217 0.1405425405911399 8.23498596685467e-12 11.084337136569852 1.9655821857011881 ETGANLAICQWGFDDEANHLLLQNNLPAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETGANLAICQWGFDDEANHLLLQNNLPAVR 30 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 139038000.0 17636000.0 88062000.0 33340000.0 False True 26755101.36430348 72346648.06845361 26750334.386558857 1.0 2.704031918375691 0.999821829202599 24.673310658951632 -6.646160473917133 2.0221431073064773 2.109043235700706 1.0069391036973685 0.17879753755244543 0.7279797446710911 0.5179070484509086 4.054685966294399 0.29240751023613115 0.8062724722953675 2.258601051972679e-07 6.646160473917133 -1.1021041320033373 ETGANLAICQWGFDDEANHLLLQNNLPAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETGANLAICQWGFDDEANHLLLQNNLPAVR 30 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 51863000.0 17636000.0 15470000.0 18757000.0 False True 22830149.657532647 14609080.900777085 15343418.463072572 1.0 0.6399029844273019 0.67206823841429 24.44443698104408 -9.932937547334344 5.725131529285327 1.0000002676107913 0.6559856118356544 0.9934860581184447 0.0131314099537294 4.485233570202829e-08 8.355908948933422e-09 0.012714442866979212 0.004238144338409028 1.1669774193556265e-10 9.932937547334344 -0.3440146557751369 ETGFHLTTTNQGASAAGPGFSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETGFHLTTTNQGASAAGPGFSLK 23 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-8;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 9333000.0 2128200.0 4282900.0 2921900.0 False True 2790090.8095181203 3643908.0146134435 2619569.8168439222 1.0 1.3060177117470908 0.9388833538706044 21.411880647761944 -6.685536949827541 1.8826016348022243 1.1926557624350553 0.9402278326075734 0.3494597084341593 0.1295443973371752 0.4263418402463591 2.9260880763021744 0.05512517567342502 0.14434522986419124 2.0628281541732777e-07 6.685536949827541 -0.25242792982748197 ETGFHLTTTNQGASAAGPGFSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETGFHLTTTNQGASAAGPGFSLK 23 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-8;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 11643100.0 3683700.0 2068400.0 5891000.0 False True 3566762.959855438 2894322.906563503 4347970.373788202 1.0 0.8114704955556706 1.2190242028207074 21.766183909602027 -6.780936269622415 1.5323726948751866 0.8933792360441067 1.2223392601015175 0.7706376020988318 0.0797581724609427 0.2491238587210756 1.1555382125373002 0.040993503494836894 0.09664595396403972 1.6560129566278508e-07 6.780936269622415 0.32896002405741076 ETGFHLTTTNQGASAAGPGFSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETGFHLTTTNQGASAAGPGFSLK 23 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-8;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 11423500.0 2128200.0 3835600.0 5459700.0 False True 2915053.0524424897 3666130.5093669626 4170231.3060510745 1.0 1.2576548156799938 1.4305850463191006 21.475090709284835 -7.999024256434611 0.060106911759796156 2.2513526933088464e-17 2.51498298638971 0.9999987065969814 0.00020112028574716576 0.11085405022208719 0.009823667937931033 0.19424423501524693 0.2096227958961641 1.0022492583831526e-08 7.999024256434611 2.51498298638971 ETGFHLTTTNQGASAAGPGFSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETGFHLTTTNQGASAAGPGFSLK 23 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-8;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 9489100.0 3683700.0 2451300.0 3354100.0 False True 3063159.7655797764 2438094.3603550433 4055426.8023938076 1.0 0.7959409717219159 1.3239357763718278 21.546589185036304 -6.801902150432695 1.4480113008985551 0.8876831718113933 1.3315824905048668 0.837712109319756 0.08757830715759925 0.21804488803521294 0.9023639231686492 0.04757538271478816 0.11052320134336835 1.5779667565360745e-07 6.801902150432695 0.44389931869347343 ETGGVEK(ub)LFSLPAQPLWNNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETGGVEKLFSLPAQPLWNNR 20 1 O60216 O60216 RAD21 Double-strand-break repair protein rad21 homolog 1 8030900.0 1086800.0 0.0 6944100.0 True False 1488619.329665677 0.0 5304046.598228697 1.0 0.0 3.563064440000192 20.505543443850463 -6.8317796355955025 1.3199920922258497 0.4663107927468294 3.662439277059634 0.9093817256205312 0.4517072108507438 0.17862275873019157 0.6080590863601834 0.2686392447790993 0.6181849585905707 1.4730597548347367e-07 6.8317796355955025 3.1961284843128044 ETGSSK(ub)GFGFVDFNSEEDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETGSSKGFGFVDFNSEEDAK 20 1 P19338;H7BY16 P19338 NCL Nucleolin 1 16346300.0 5095500.0 7102200.0 4148600.0 True False 4933746.141635681 9938145.497483723 3061957.204667754 1.0 2.014320399182301 0.6206150695164518 22.234252055204347 -6.711523343421035 1.7895845088152695 1.6225980365109118 0.6237116136425918 0.4724309949711074 0.42732754190323097 0.37201707546665813 2.3233710923636246 0.18994902298260216 0.48170482795008907 1.9430172514299022e-07 6.711523343421035 -0.9988864228683201 ETGSSK(ub)GFGFVDFNSEEDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETGSSKGFGFVDFNSEEDAK 20 1 P19338;H7BY16 P19338 NCL Nucleolin 1 8788300.0 2566200.0 3863700.0 2358400.0 True False 3514993.488947422 3692988.958452691 1801394.4927726511 1.0 1.0506389186964242 0.5124887139725786 21.745090586225977 -6.883848865266079 1.0580589907791056 1.0333209942799186 0.4714131091761523 0.9766613981685007 0.037066995025208084 0.12427719056698462 0.25212516092288434 0.026885513314199833 0.06570323691476888 1.3066255154661937e-07 6.883848865266079 -0.5619078851037663 ETGSSK(ub)GFGFVDFNSEEDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETGSSKGFGFVDFNSEEDAK 20 1 P19338;H7BY16 P19338 NCL Nucleolin 1 13437200.0 5095500.0 5332200.0 3009500.0 True False 4237134.018924377 5303474.3802411705 3638772.535644189 1.0 1.251665478730241 0.8587815536143731 22.014657330638624 -6.733689399504469 1.7096744499574708 1.150824478668548 0.8588486817572091 0.5763263826965894 0.10576708095345055 0.3293661378885824 1.8876718482210206 0.048990870417345726 0.12106787583123015 1.8463354167821776e-07 6.733689399504469 -0.2919757969113389 ETIEQEK(ub)QAGES ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETIEQEKQAGES 12 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 23779800.0 12850000.0 7131400.0 3798400.0 True False 16846474.43957703 6067422.91797947 3405378.004825614 1.0 0.36015980315296214 0.20214187942050588 24.005943365961564 -13.999999999999993 0.19641254168899197 4.5093492323509015 0.09581261889573023 0.9994871408404146 0.007811974317781418 12.462248322237139 0.14053845466754733 16.777006587199114 0.10337703613546492 1.0000000000000164e-14 13.999999999999993 -4.413536613455172 ETIEQEK(ub)QAGES ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETIEQEKQAGES 12 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 37804700.0 15794000.0 14249000.0 7761700.0 True False 15292628.115198508 19938700.007553376 5728677.923991154 1.0 1.303811212654638 0.37460388631943087 23.866333026629352 -6.8186506475815305 1.37783632731646 1.1639757677864868 0.3549194061705077 0.8812275176435205 0.1333201898354581 0.19523733105535715 0.7286811747460876 0.07604674778891592 0.17533030350244813 1.5182711944736088e-07 6.8186506475815305 -0.8090563616159792 down ETIEQEK(ub)QAGES ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETIEQEKQAGES 12 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 38376200.0 19926000.0 13663000.0 4787200.0 True False 30229198.785728708 11224730.900493754 3841007.8216957054 1.0 0.37132082064288724 0.1270628391086917 24.84943940555975 -9.78647430140011 0.25703501290469194 1.4869607620235898 4.1139300901128786e-25 0.9990201201004034 0.011510545559259434 1.214014177161622 0.11180804895534437 0.5515622388776048 0.10329104073700832 1.635029898239839e-10 9.78647430140011 -1.4869607620235898 ETIEQEK(ub)QAGES ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETIEQEKQAGES 12 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 25309800.0 12850000.0 7753600.0 4706200.0 True False 17600992.25819283 7411020.314273579 3594692.487231453 1.0 0.42105696119626046 0.2042323770444369 24.069153427484455 -11.63007297145268 0.17520195898006083 2.288674649582117 7.433721514538203e-15 0.999488970046749 0.0075932493146276875 4.448040952169145 0.10933534133190485 2.318272853456164 0.16375005900827308 2.3438349640995037e-12 11.63007297145268 -2.2886746495821093 ETIEQEK(ub)QAGES ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETIEQEKQAGES 12 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 41497400.0 15794000.0 21387000.0 4316400.0 True False 13133410.792835178 21271783.986012895 5218939.283221326 1.0 1.6196694310070265 0.39737881998395075 23.64673830206363 -6.768866261643197 1.5786768602896006 1.35593671299565 0.390776204560003 0.7262599861334351 0.26108509174630007 0.268259640979211 1.3192406899188032 0.13036889485478803 0.310670693805438 1.70268275851968e-07 6.768866261643197 -0.9651605084356472 ETIEQEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETIEQEKR 8 1 P63313 P63313 TMSB10 Thymosin beta-10 1 3360400.0 1189300.0 1158100.0 1013000.0 True False 1559183.8171975827 985315.9942384443 908184.4773821465 1.0 0.6319434459045461 0.5824742838945587 20.57235959134742 -13.999999999999998 0.2828246768940913 4.046824853503612 0.5679919078549283 0.999611444088586 0.003671551459273867 15.553173289873401 0.1685121419500049 27.45563714173057 0.01930988415531841 1.0000000000000041e-14 13.999999999999998 -3.4788329456486835 ETIEQEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETIEQEKR 8 1 P63313 P63313 TMSB10 Thymosin beta-10 1 3955230.0 1673600.0 1284900.0 996730.0 True False 1620472.4840823251 1797967.2706649797 735656.5117409466 1.0 1.1095327371036294 0.45397655249761887 20.62798309296357 -6.863958021987653 1.1656590848136068 1.06017045612897 0.4197588180728046 0.9582671510767207 0.058573638237464073 0.14277584050127884 0.36642541644238746 0.03912588850029007 0.0917726952456783 1.367861033843469e-07 6.863958021987653 -0.6404116380561654 down ETIEQEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETIEQEKR 8 1 P63313 P63313 TMSB10 Thymosin beta-10 1 3307940.0 1189300.0 997540.0 1121100.0 True False 1629016.349624024 953465.3843763489 856319.269779266 1.0 0.5853012982935427 0.5256664673604435 20.635569652870313 -13.999999999999998 0.2731510006711253 4.255643436695603 0.5064682199378651 0.9995901415613786 0.004270801229644477 15.03984120425367 0.16547515223392673 27.24158633520436 0.024383564572858573 1.0000000000000041e-14 13.999999999999998 -3.749175216757738 ETIEQEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETIEQEKR 8 1 P63313 P63313 TMSB10 Thymosin beta-10 1 3662790.0 1673600.0 1213700.0 775490.0 True False 1391672.5530510936 1207161.5571994137 937641.3735393618 1.0 0.8674178092776499 0.6737514305959998 20.408388368397848 -6.965694368240605 0.3459277743901099 1.019614565421318 0.5150602981976445 0.9999267502214796 0.001146550950239787 0.07772611390668133 0.01403349396209804 0.00268718992218466 0.016692111449905195 1.0821952708703855e-07 6.965694368240605 -0.5045542672236735 ETIGSAQCK(ub)ELFASALSNDLLQNCQVSEEDGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETIGSAQCKELFASALSNDLLQNCQVSEEDGR 32 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 17332900.0 10069000.0 2704200.0 4559700.0 True False 8372819.632332366 2689631.9378583254 5513112.18832923 1.0 0.32123371289070646 0.6584534757012884 22.99728211618078 -10.601319993594267 6.5927335978351085 1.00120036209038 0.48984359429640456 0.7531804091284949 0.13766939167804945 0.0024338460996455855 0.0001471811890570821 0.13356698434261793 0.044432605104299285 2.504263400565282e-11 10.601319993594267 -0.5113567677939754 ETIGSAQCK(ub)ELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAMESSQIVSR 45 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 37965000.0 13301000.0 12283000.0 12381000.0 True False 17218406.701907534 11599440.252375217 10127785.039787902 1.0 0.6736651336671109 0.5881952502995471 24.03744831393785 -13.999999999999998 0.18808051969212466 2.737908592952452 0.5256798736199813 0.9994905781358793 0.0040050113377214525 12.320093381068801 0.1375261758862352 7.841885558839194 0.05968853160436564 1.0000000000000041e-14 13.999999999999998 -2.2122287193324706 ETIIAFAWEPNGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETIIAFAWEPNGSK 14 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 8019600.0 1933000.0 3658100.0 2428500.0 False True 2534181.7191986297 3112325.7391621163 2177222.1158169224 1.0 1.2281383436647588 0.8591420651970504 21.273088549204196 -6.739463487522706 1.6886874573969017 1.1358257943617232 0.8589520673197685 0.6025212516857386 0.09585520838132057 0.3187872175561629 1.7847732846462567 0.04490934658406041 0.11026732805632274 1.8219502436324026e-07 6.739463487522706 -0.2768737270419547 ETIIAFAWEPNGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETIIAFAWEPNGSK 14 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 7910300.0 3232600.0 0.0 4677700.0 False True 3129982.8824357805 0.0 3452470.042007993 1.0 0.0 1.1030316048633628 21.57772333654835 -10.668165066408047 4.274275013241327 1.0171156446758292 0.5515158024362603 0.18061203810862492 0.4503107670138281 0.07413855943882017 0.005755770187228026 0.4401212176944871 0.1453371751050996 2.1470142830226682e-11 10.668165066408047 -0.46559984223956885 ETIIAFAWEPNGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETIIAFAWEPNGSK 14 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 51441000.0 12384000.0 20387000.0 18670000.0 False True 18787433.391672384 16748780.565641986 14979866.316648318 1.0 0.8914884868236425 0.7973343673057658 24.163264653480294 -6.972785203001651 0.17960476164830969 1.0731684897414875 0.613109275677469 0.9999967436253998 0.00014931733168093987 0.07540898026151253 0.005661624561282558 0.0036384677997447876 0.010578898811569554 1.0646694611568785e-07 6.972785203001651 -0.4600592140640185 ETIIAFAWEPNGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETIIAFAWEPNGSK 14 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 8743800.0 1933000.0 2758000.0 4052800.0 False True 2647682.3373608356 2636142.4405136346 3095612.1100360407 1.0 0.9956415100541465 1.16917806428459 21.336298610727088 -6.9011392011316035 0.954033295039101 0.9930087741132303 1.1878213089323948 0.9871247220389279 0.009168112526133991 0.11057174356555459 0.17272632990882858 0.0071916715183313025 0.01882083911616004 1.255627442404938e-07 6.9011392011316035 0.1948125348191645 ETIIAFAWEPNGSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETIIAFAWEPNGSK 14 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 10235000.0 3232600.0 2733200.0 4269200.0 False True 2688050.1284613786 2718475.709102277 5161869.981449474 1.0 1.0113188293323658 1.9203027230761103 21.358128611982625 -6.909617002961086 0.8983369566944746 0.9715137229676868 2.036817097204997 0.9907762208950835 0.04141187427475127 0.10467206503676905 0.1401445172672063 0.033840329985065525 0.09316884020450991 1.2313542028038068e-07 6.909617002961086 1.0653033742373101 ETIIAFAWEPNGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETIIAFAWEPNGSK 14 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 42181000.0 12384000.0 15533000.0 14264000.0 False True 16031332.125135185 14668574.895395638 11668098.360999495 1.0 0.9149941365382289 0.7278308670746912 23.934390975572743 -6.958122849200701 0.4611340582411008 1.0053941328233242 0.6298716754952358 0.9996940952634787 0.0019884736631404364 0.08037870994309097 0.023662042329339536 0.002546822771015118 0.01545967441294198 1.1012277603698951e-07 6.958122849200701 -0.3755224573280884 ETIMNQEK(ub)LAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETIMNQEKLAK 11 1 P20290;P20290-2;D6RDG3 P20290;P20290-2 BTF3 Transcription factor BTF3 1 11081770.0 4748600.0 4920770.0 1412400.0 True False 6225460.585507818 4186610.297011223 1266258.396697475 1.0 0.6724980809865198 0.2033999539962046 22.569749147042526 -7.324112032549975 0.4282122729950475 1.024950475411787 6.488197929712811e-24 0.9992069293404847 0.009206520910104616 0.10413521940573298 0.038324172379172045 0.013073271838233487 0.05512120128074745 4.741196634513783e-08 7.324112032549975 -1.024950475411787 down ETIMNQEK(ub)LAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETIMNQEKLAK 11 1 P20290;P20290-2;D6RDG3 P20290;P20290-2 BTF3 Transcription factor BTF3 1 24477500.0 6943300.0 12101500.0 5432700.0 True False 6722888.742070262 16933692.058488827 4009712.892493501 1.0 2.5188118840226745 0.5964270786457698 22.680649843749855 -6.696091207533455 1.8447123469114985 1.9466992279575352 0.6025259626922487 0.3991143697693088 0.6415774394865712 0.403698703154859 2.6679598184706355 0.27774926958739554 0.7177902643552309 2.0133013857812827e-07 6.696091207533455 -1.3441732652652867 ETIMNQEK(ub)LAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETIMNQEKLAK 11 1 P20290;P20290-2;D6RDG3 P20290;P20290-2 BTF3 Transcription factor BTF3 1 11082500.0 3880200.0 3155300.0 4047000.0 True False 5886547.080617503 2592212.0625285753 3247108.6761368844 1.0 0.4403620708418169 0.5516151712824252 22.488990198217554 -10.492067190928564 5.640044854669542 1.0006881395437728 0.4959886210623602 0.9647452623112722 0.045418888063684604 0.00039350926982657184 3.5438689239280526e-05 0.044033151418613185 0.014658883089492179 3.220570489161372e-11 10.492067190928564 -0.5046995184814126 ETIMNQEK(ub)LAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETIMNQEKLAK 11 1 P20290;P20290-2;D6RDG3 P20290;P20290-2 BTF3 Transcription factor BTF3 1 27285300.0 6943300.0 19159000.0 1183000.0 True False 5773661.590343955 19055786.66423625 1430359.8304260103 1.0 3.300468232517424 0.24773877166929684 22.46105511918413 -6.705082156814074 1.8127876890863797 2.421266331730689 0.2558609340435124 0.44185372117841115 0.9701719368077917 0.3849587545519408 2.4628072839669213 0.4264085680989739 1.0897662037518587 1.972049642170147e-07 6.705082156814074 -2.1654053976871763 ETIVLK(ub)EGSEYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETIVLKEGSEYR 12 1 P52566;F5H3P3;H0YGX7;F5H6Q0 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 8498900.0 2739700.0 4083800.0 1675400.0 True False 3591773.2312925444 3474512.9585277247 1502045.6795716176 1.0 0.9673530968650206 0.41819056573097957 21.776264836881765 -6.919087944999295 0.8314662914167983 1.0125199943990097 0.3314656150162774 0.9939236871850592 0.0208054816929732 0.09871155522033616 0.10841816859676016 0.01783997263168857 0.05298179459961457 1.2047919442819047e-07 6.919087944999295 -0.6810543793827324 down ETIVLK(ub)EGSEYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETIVLKEGSEYR 12 1 P52566;F5H3P3;H0YGX7;F5H6Q0 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 11372100.0 3555400.0 2726500.0 5090200.0 True False 3442535.7731275684 3815205.668509671 3756923.917273254 1.0 1.1082544728485215 1.091324583058744 21.715040215534984 -10.115472169816758 4.185978269166773 0.9999805089842202 1.0997895279677916 0.9788687892754334 0.0069115986234450635 4818439.998541952 0.014367666852518654 919.1554599581879 0.0023660240378651277 7.665276587275149e-11 10.115472169816758 0.09980901898357142 ETIVLK(ub)EGSEYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETIVLKEGSEYR 12 1 P52566;F5H3P3;H0YGX7;F5H6Q0 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 7843800.0 2739700.0 1755900.0 3348200.0 True False 3752641.127608631 1678318.5320151867 2557424.1183435335 1.0 0.44723661947517335 0.6814997841195785 21.839474898404656 -10.306563717721497 5.7380299652452145 1.0000457258098625 0.5643682017973761 0.8217701326986258 0.0956375364847432 5.594991371865353e-05 6.7616714098440005e-06 0.09261033119016591 0.030866882173141378 4.93669483983027e-11 10.306563717721497 -0.4356775240124864 ETIVLK(ub)EGSEYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETIVLKEGSEYR 12 1 P52566;F5H3P3;H0YGX7;F5H6Q0 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 9160500.0 3555400.0 2947100.0 2658000.0 True False 2956472.6309260624 2931223.3873464507 3213775.510796562 1.0 0.9914596728156747 1.087030360835745 21.49544549096926 -6.885094223790173 1.050936984837678 0.9942449047434206 1.0945026442007466 0.9775692121523359 0.006467098340551021 0.12321510732741828 0.24580656831204295 0.004716260492362315 0.011568451135774458 1.3028840762787924e-07 6.885094223790173 0.10025773945732597 ETK(ub)AADPPAENSSAPEAEQGGAE ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETKAADPPAENSSAPEAEQGGAE 23 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 59694000.0 24309000.0 23029000.0 12356000.0 True False 31869334.408690855 19593162.966338947 11077519.647121213 1.0 0.6147967420680063 0.34759181051802396 24.92566555294424 -8.114767078596847 0.19663401517254778 1.2703220275847251 2.2568731726399334e-15 0.99982409890771 0.0035516688142620658 0.09048286011357126 0.03787973933035284 0.09355342677430634 0.11033028513975487 7.677731520941879e-09 8.114767078596847 -1.270322027584723 down ETK(ub)AADPPAENSSAPEAEQGGAE ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETKAADPPAENSSAPEAEQGGAE 23 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 72234000.0 24748000.0 27757000.0 19729000.0 True False 23962388.28637031 38840514.850842826 14561383.04268672 1.0 1.6208949786918827 0.6076766167322797 24.51426837021763 -6.740844556974226 1.683324050550931 1.3690522373629246 0.6069355015132669 0.608903402478368 0.2608688011403889 0.31626186893793434 1.7598731864834252 0.12257594567865308 0.3005445229026859 1.8161655898848728e-07 6.740844556974226 -0.7621167358496577 ETK(ub)AADPPAENSSAPEAEQGGAE ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETKAADPPAENSSAPEAEQGGAE 23 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 58363000.0 24309000.0 23096000.0 10958000.0 True False 33296694.226024047 22075542.35174141 8369946.087094099 1.0 0.6629950169193553 0.25137468693670834 24.98887561446713 -7.3244533151716835 0.3612866679924854 1.0460076090396304 1.408311178003231e-13 0.9996388413728159 0.005817756361582888 0.10588160111045201 0.029090100522560777 0.012828573005399652 0.052783205368202364 4.73747231270342e-08 7.3244533151716835 -1.0460076090394896 down ETK(ub)AADPPAENSSAPEAEQGGAE ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETKAADPPAENSSAPEAEQGGAE 23 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 71782000.0 24748000.0 34839000.0 12195000.0 True False 20579058.522292327 34651315.3919999 14744918.11669076 1.0 1.6838144152446897 0.7165011023569559 24.294673645651905 -6.716752845381357 1.7707441750205348 1.417446504649869 0.7182480038852304 0.49730967855685526 0.2878707191084434 0.36164291715851876 2.214233061443481 0.12916646158342404 0.32553238969375325 1.9197609553329538e-07 6.716752845381357 -0.6991985007646386 ETK(ub)EEEEAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETKEEEEAER 10 1 O95071;E7EMW7;O95071-2;H0YAV7 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 3836510.0 930410.0 1316200.0 1589900.0 True False 1219776.5201032558 1119828.0905074156 1425392.3993977052 1.0 0.9180600479279767 1.16856848439503 20.21818541967606 -6.818604505497 1.3779564645741083 0.955772112817912 1.1738730957117443 0.8811353762602908 0.03595512724074241 0.19529857268991943 0.7290364357333944 0.020506909652733638 0.0472823494591126 1.5184325133999233e-07 6.818604505497 0.21810098289383228 ETK(ub)EEEEAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETKEEEEAER 10 1 O95071;E7EMW7;O95071-2;H0YAV7 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 3307370.0 719570.0 1227500.0 1360300.0 True False 696727.6442227042 1717647.1513279343 1003996.6218747401 1.0 2.4653064444489017 1.4410173475961856 19.410235281006692 -10.35239465165483 5.895454460323033 0.9998550431199278 1.9531618960225452 0.5358741109246392 0.4181642727309008 0.0007968357473834406 8.753160564666562e-05 0.4049458025225535 0.13496193868880874 4.442274061066985e-11 10.35239465165483 0.9533068529026174 ETK(ub)EEEEAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETKEEEEAER 10 1 O95071;E7EMW7;O95071-2;H0YAV7 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 3202570.0 930410.0 868960.0 1403200.0 True False 1274407.7203848376 830566.4739335495 1071793.0598111378 1.0 0.6517274343588724 0.841012685867506 20.281395481198953 -10.181716873995214 5.010270509543074 1.0000201548979102 0.7463700601128394 0.7053538252789526 0.07727538033963587 1.7398733379032455e-05 2.841695822439102e-06 0.07482750630379759 0.02494052176043076 6.58086718565943e-11 10.181716873995214 -0.25365009478507083 ETK(ub)EEEEAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETKEEEEAER 10 1 O95071;E7EMW7;O95071-2;H0YAV7 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 2692750.0 719570.0 967380.0 1005800.0 True False 598354.3373559839 962168.5319301034 1216108.1297062393 1.0 1.6080246634155717 2.032421349329553 19.190640556440968 -7.722215977800362 0.11216243659819203 1.463098618614686e-19 3.332594893716583 0.9999913720056188 0.0012445415849706592 0.13801240919940752 0.01383625612585037 0.1672338276774254 0.22275513125381494 1.895762910082323e-08 7.722215977800362 3.332594893716583 ETK(ub)MLMAAGDKDGDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETKMLMAAGDKDGDGK 16 2 B8ZZ19;P20472;H0Y3U0;B1AH72 B8ZZ19 PVALB Parvalbumin alpha 1 4707900.0 1497500.0 1093500.0 2116900.0 True False 1963237.0018106303 930354.0624296148 1897863.4947386617 1.0 0.47388779936990755 0.9667011639391083 20.90480291466911 -10.620211465299151 9.581520624156264 1.0000642316911488 0.720294481654508 0.30046084287942343 0.2011902136031207 0.00027611604737061375 1.0944405764108386e-05 0.19484592862289501 0.06493386222539994 2.3976651711827697e-11 10.620211465299151 -0.27976975003664073 ETK(ub)MLMAAGDKDGDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETKMLMAAGDKDGDGK 16 2 B8ZZ19;P20472;H0Y3U0;B1AH72 B8ZZ19 PVALB Parvalbumin alpha 1 9728000.0 2014900.0 2044200.0 5668900.0 True False 1950938.1024005 2860459.72036217 4184045.026645387 1.0 1.4661970653208136 2.144632380441592 20.895736575473865 -6.965755624126919 0.34483779951311827 0.9304180498803124 2.703124108770325 0.9999278849339597 0.003990959862542324 0.07770547100502703 0.013961013953856842 0.009442107559833593 0.058518645231120096 1.0820426413565288e-07 6.965755624126919 1.7727060588900128 ETK(ub)MLMAAGDKDGDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETKMLMAAGDKDGDGK 16 2 B8ZZ19;P20472;H0Y3U0;B1AH72 B8ZZ19 PVALB Parvalbumin alpha 1 6479700.0 1497500.0 1670300.0 3311900.0 True False 2051166.2184158568 1596500.6230565344 2529697.4307215703 1.0 0.7783380053370483 1.2332971399437778 20.968012976192 -6.774268362454272 1.5585535220242381 0.873552063130846 1.236251871685408 0.7464530374013123 0.09353481782100101 0.2595899299353338 1.245054762340178 0.047292570573265996 0.11212079342790665 1.681634611870337e-07 6.774268362454272 0.3626998085545621 ETK(ub)MLMAAGDKDGDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETKMLMAAGDKDGDGK 16 2 B8ZZ19;P20472;H0Y3U0;B1AH72 B8ZZ19 PVALB Parvalbumin alpha 1 8242800.0 2014900.0 2641800.0 3586100.0 True False 1675478.6252047375 2627568.0990437586 4335936.929747013 1.0 1.5682492509999517 2.5878795852839827 20.67614185090814 -6.962110169886674 0.40459744763655986 0.9467142061342906 3.2469233443890335 0.9998406318445214 0.00829304955911767 0.07895576603660466 0.018408182916342424 0.013117650574054635 0.08528650253724625 1.0911634998482142e-07 6.962110169886674 2.300209138254743 ETK(ub)PEPMEEDLPENKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETKPEPMEEDLPENKK 16 2 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 4753800.0 1571800.0 1664100.0 1517900.0 True False 2060645.0213328528 1415822.7666109933 1360842.268724936 1.0 0.6870774694106315 0.6603962616737963 20.97466456858704 -13.999999999999998 0.3486911916283079 4.8173248900380345 0.6566459177284514 0.9997522066447296 0.0024271229780794728 20.530085574667766 0.18999329605396853 58.01209061527866 0.007996365695064992 1.0000000000000041e-14 13.999999999999998 -4.160678972309583 ETK(ub)PEPMEEDLPENKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETKPEPMEEDLPENKK 16 2 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 4599900.0 1571800.0 1294700.0 1733400.0 True False 2152936.9362978577 1237495.872999638 1324006.620493605 1.0 0.574794297099853 0.6149769638725867 21.037874630109933 -9.881998184878269 6.823605790822573 1.0000000095231207 0.5948856310603046 0.9926752848173092 0.016404505016271425 2.395102686394242e-09 3.815466673982787e-10 0.015883594156055884 0.005294531227562753 1.3122053833337162e-10 9.881998184878269 -0.40511437846281617 ETKPEPMEEDLPENKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETKPEPMEEDLPENKK 16 2 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 0 8792560.0 2514440.0 615020.0 5663100.0 False True 2434620.4785348717 860600.693286931 4179764.2206416517 1.0 0.353484537271629 1.7168031968403505 21.215265464256163 -6.777752813302519 1.544671699764913 0.6328608827321773 1.7268430950757347 0.7593491628808855 0.27315411875027384 0.25407847699879593 1.1972748669750555 0.13930421188057893 0.3293160654302845 1.668196427093286e-07 6.777752813302519 1.0939822123435574 ETLK(ub)NSALSAQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETLKNSALSAQLR 13 1 P47897;P47897-2;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RQU2;F2Z2V6;A0A0U1RQC3 P47897 QARS Glutamine--tRNA ligase 1 4872370.0 701870.0 2524400.0 1646100.0 True False 920158.3669187491 2147769.360034128 1475777.3625061715 1.0 2.3341301206945158 1.603829748837663 19.811522656808584 -10.141087980518572 4.912188676588516 0.9999501714782114 1.9689799347630903 0.7012501448451711 0.2981438783897588 0.00019102987586278497 3.340243770504077e-05 0.2886938699095441 0.0962255229733864 7.226233978242181e-11 10.141087980518572 0.9690297632848789 ETLK(ub)NSALSAQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETLKNSALSAQLR 13 1 P47897;P47897-2;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RQU2;F2Z2V6;A0A0U1RQC3 P47897 QARS Glutamine--tRNA ligase 1 7476600.0 1518400.0 1473600.0 4484600.0 True False 1470199.2231301386 2062016.1647224813 3309948.724883824 1.0 1.4025420040233259 2.2513606814706058 20.487580233737738 -6.958997656561029 0.4493449979425848 0.972443361998493 2.7150718753429617 0.9997311754645568 0.008551800178369193 0.08006125546206565 0.02246985042570863 0.011334318438356661 0.07021811340443218 1.099011769648468e-07 6.958997656561029 1.7426285133444686 up ETLK(ub)NSALSAQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETLKNSALSAQLR 13 1 P47897;P47897-2;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RQU2;F2Z2V6;A0A0U1RQC3 P47897 QARS Glutamine--tRNA ligase 1 3958970.0 701870.0 1634700.0 1622400.0 True False 961370.306323564 1562473.5487699907 1239222.5343768457 1.0 1.625256717929164 1.2890168608554529 19.874732718331476 -10.112917193849777 4.5161193080716 0.9999601669375761 1.4571367894020573 0.711359892538806 0.13726934692298887 95673531.47893937 3.8617302130408895 44837.73154498341 0.04699094858902777 7.710504698604772e-11 10.112917193849777 0.4571766224644812 ETLK(ub)NSALSAQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETLKNSALSAQLR 13 1 P47897;P47897-2;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RQU2;F2Z2V6;A0A0U1RQC3 P47897 QARS Glutamine--tRNA ligase 1 6057500.0 1518400.0 2516300.0 2022800.0 True False 1262616.8765253215 2502744.192453559 2445758.127629526 1.0 1.9821881355974154 1.9370548367452276 20.267985509172014 -10.270449570952707 5.442648772280611 0.9998973371736505 1.9596214861713706 0.9983437128889603 0.018425592099572424 2.2955800763882536e-05 3.077059376257142e-06 0.0178423814821081 0.005946834278779662 5.3647616191879274e-11 10.270449570952707 0.9597241489977201 ETLK(ub)SLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETLKSLK 7 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 12453600.0 4814900.0 5382500.0 2256200.0 True False 6312380.527557928 4579451.980820674 2022750.0669986159 1.0 0.7254714700465512 0.3204417189629025 22.58975274689881 -6.981935648252678 0.3518065233337543 1.038764475453242 2.0582597541208883e-10 0.9999242851342403 0.0024288099398190764 0.0756883299840828 0.014233957477964186 0.005503139687238015 0.03389196579018952 1.0424718866114217e-07 6.981935648252678 -1.0387644752474159 down ETLK(ub)SLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETLKSLK 7 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 12416500.0 4182100.0 5814800.0 2419600.0 True False 4049341.524665807 8136679.963781419 1785834.173555925 1.0 2.009383479812299 0.441018413161214 21.94925589551046 -6.732879343191111 1.7124157427473305 1.6054650591824096 0.441388026341937 0.5727447535088754 0.42423273253630756 0.33084285710671835 1.9018282371504762 0.1962079695192866 0.48535643659603483 1.8497824589123898e-07 6.732879343191111 -1.1640770328404726 ETLK(ub)SLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETLKSLK 7 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 10114700.0 4814900.0 3098100.0 2201700.0 True False 6595098.647779968 2961215.6979533327 1681703.8054348496 1.0 0.44900248746849797 0.25499297209162175 22.6529628084217 -13.999999999998002 0.14547416909309793 3.6474969562285726 0.030024041258894442 0.9995820401563501 0.006451580337520735 11.94358827902309 0.11986898487510267 8.952405782643016 0.20194990895266385 1.0000000000046014e-14 13.999999999998002 -3.617472914969678 ETLK(ub)SLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETLKSLK 7 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 12833700.0 4182100.0 6179200.0 2472400.0 True False 3477601.4484434635 6145911.423124828 2989367.4089140035 1.0 1.7672845822731271 0.8596060972576406 21.729661170944738 -6.682642323221854 1.89212211054578 1.4843242822301712 0.8629627050638842 0.3362619660671232 0.3250098821839824 0.4327758043627126 2.9977253063817475 0.13770272208606904 0.3620070085299854 2.0766230811413978e-07 6.682642323221854 -0.621361577166287 ETLLAMFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETLLAMFK 8 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 4482600.0 1274500.0 1149400.0 2058700.0 False True 1670881.842275556 977914.0003261091 1845685.4724448419 1.0 0.5852681952628671 1.104617589195429 20.67217828501516 -6.694019131175406 1.852232325834509 0.7409764366474576 1.102911037945966 0.38929298268279067 0.17526152487214827 0.4080659022037591 2.7173488270462527 0.07561150360403811 0.1958988716159316 2.022930064300974e-07 6.694019131175406 0.3619346012985083 ETLLAMFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETLLAMFK 8 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 5157800.0 1274500.0 1756600.0 2126700.0 False True 1745717.0920674498 1678987.603700599 1624417.2607613623 1.0 0.9617753136117702 0.9305157566152759 20.735388346538052 -6.973423940927669 0.1561123102963271 1.033376701304327 0.8580878893709865 0.9999982227065577 3.743799429474079e-05 0.07520695249725416 0.00480024908190596 0.0015021176732685833 0.0038064164472184775 1.0631047511512851e-07 6.973423940927669 -0.17528881193334045 ETLLGK(ub)VVALPDHLGNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETLLGKVVALPDHLGNR 17 1 Q9Y4R8;H3BRS3 Q9Y4R8 TELO2 Telomere length regulation protein TEL2 homolog 1 116933100.0 5177100.0 18690000.0 93066000.0 True False 7854039.196707619 15354623.474363483 74671464.3077232 1.0 1.9549970518099882 9.50739644118725 22.905003367322703 -6.930311012582067 0.7442350823641789 0.886466748878665 11.070215409701445 0.9965990195138057 0.22192041953739927 0.09247663644428994 0.076891423711236 0.20255547689692627 0.682196769736421 1.1740564733040269e-07 6.930311012582067 10.183748660822781 ETLLGK(ub)VVALPDHLGNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETLLGKVVALPDHLGNR 17 1 Q9Y4R8;H3BRS3 Q9Y4R8 TELO2 Telomere length regulation protein TEL2 homolog 1 85510200.0 5177100.0 8961100.0 71372000.0 True False 6701858.005897725 8462406.907560024 58383028.338562526 1.0 1.2626956435234815 8.711469011606136 22.676129689415152 -6.914377557519524 0.8653856913146787 0.8000570848736581 9.770007876655043 0.9924714355535481 0.310185498630197 0.10159423279382873 0.12358953070404802 0.25958273800869314 0.7402888068744099 1.2179303206925613e-07 6.914377557519524 8.969950791781386 up ETLLNSATTSLNSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETLLNSATTSLNSK 14 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 39332900.0 8722900.0 15057000.0 15553000.0 False True 11435806.372683754 12810554.291726297 13943724.754910693 1.0 1.1202143403132767 1.2193040263621024 23.447054762261548 -6.973339107897467 0.15937810348221584 0.8988528343151894 1.4432931955152701 0.9999980928310692 0.000123698264040157 0.0752334571617723 0.0049167311448815735 0.004613751718870945 0.011918235136292022 1.0633124332888343e-07 6.973339107897467 0.5444403612000808 ETLLNSATTSLNSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETLLNSATTSLNSK 14 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 40374900.0 10674000.0 3541900.0 26159000.0 False True 10335159.712652212 4956199.140764491 19307173.14682154 1.0 0.47954741664003075 1.8681059300114993 23.30105734759231 -6.805190068351718 1.434705317081742 0.7147052320819274 1.8898052262272484 0.8468830690730083 0.22412521274196895 0.21343332784581456 0.8667277578687838 0.12286767061759574 0.28488067678887596 1.566065533791842e-07 6.805190068351718 1.175099994145321 ETLLNSATTSLNSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETLLNSATTSLNSK 14 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 40363900.0 8722900.0 18690000.0 12951000.0 False True 11947991.85750895 17864214.000435024 9892240.534217527 1.0 1.4951645609975797 0.8279416869539089 23.51026482378444 -6.707971164660173 1.8026247924450656 1.3050468116838456 0.8296131593292806 0.4553968531716126 0.20872695757851864 0.3791568799084683 2.4004381620033155 0.09219349656549765 0.23477634338759792 1.9589747369292498e-07 6.707971164660173 -0.47543365235456503 ETLLNSATTSLNSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETLLNSATTSLNSK 14 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 15326600.0 10674000.0 2702300.0 1950300.0 False True 8875903.938376779 2687742.173535448 2358098.7128316523 1.0 0.3028133463583858 0.26567420391245244 23.081462623026585 -13.580457429143099 0.42151081792449363 9.999999913761028 0.26450351834024116 0.9998595913868454 0.004002149770776638 20.861622167660453 0.21627760633082838 170.79960613038472 0.008979917126965886 2.6274990692412113e-14 13.580457429143099 -9.735496395420787 ETLPAEQDLTTK(ub)NVSIGIVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETLPAEQDLTTKNVSIGIVGK 21 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 27807100.0 8959000.0 12700000.0 6148100.0 True False 11745335.759079406 10805209.504212255 5511953.5887395535 1.0 0.9199574814929907 0.46928872037384634 23.485584619880512 -6.937195141955074 0.6851590510185964 1.0053872879570125 0.35716993496799 0.9977729803729853 0.011024370359816273 0.08906981805048288 0.06061303595799189 0.010515726165781844 0.039291420257054496 1.1555928818632538e-07 6.937195141955074 -0.6482173529890225 down ETLPAEQDLTTK(ub)NVSIGIVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETLPAEQDLTTKNVSIGIVGK 21 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 76282000.0 25934000.0 30000000.0 20348000.0 True False 25110739.365553882 41979156.44793329 15018248.373084761 1.0 1.671761067518345 0.5980806918686878 24.581801172443175 -6.737570598673481 1.6958946554923866 1.40082143137814 0.5978149290100716 0.5938689260271774 0.2822649694978202 0.32222271122527685 1.8187376412610787 0.13173079124475592 0.3240836715447872 1.8299086131880896e-07 6.737570598673481 -0.8030065023680684 ETLPAEQDLTTK(ub)NVSIGIVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETLPAEQDLTTKNVSIGIVGK 21 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 92986000.0 21208000.0 40700000.0 31078000.0 True False 32174086.512482848 33436767.009448558 24935419.67802872 1.0 1.0392452633107647 0.7750156222261142 24.93939585220314 -6.869109045616186 1.1387309127311807 1.0220827120770732 0.759796361270981 0.9637893990633128 0.0221530147627648 0.13771556036789698 0.3343047504232179 0.01510535294208406 0.035710060970604536 1.3517331182239692e-07 6.869109045616186 -0.2622863508060922 ETLPAEQDLTTK(ub)NVSIGIVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETLPAEQDLTTKNVSIGIVGK 21 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 31238000.0 8959000.0 12252000.0 10027000.0 True False 12271384.407871542 11710666.128054023 7658829.11254722 1.0 0.954306844184765 0.6241210329646608 23.548794681403404 -6.932039959918779 0.7298538984792496 1.004660649666338 0.5526746059781342 0.9969241697798233 0.009287539481262184 0.09159247245429555 0.07259220060283374 0.008566465171360385 0.02954816135254596 1.1693917890292682e-07 6.932039959918779 -0.4519860436882037 ETLPAEQDLTTK(ub)NVSIGIVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETLPAEQDLTTKNVSIGIVGK 21 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 57795000.0 25934000.0 19117000.0 12744000.0 True False 21565270.07100085 19014012.926572613 15408711.478401588 1.0 0.8816960262482892 0.7145151174861435 24.36220644787745 -6.9662294717414195 0.33628351769687304 1.018931874387109 0.5717545074602733 0.9999362896942532 0.0009347929096227992 0.07754618863861082 0.013402265109353034 0.002387795486087712 0.014510379140660274 1.0808626960940679e-07 6.9662294717414195 -0.44717736692683563 ETLPAEQDLTTK(ub)NVSIGIVGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETLPAEQDLTTKNVSIGIVGK 21 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 107344000.0 21208000.0 48433000.0 37703000.0 True False 27454174.07217916 45737660.97397135 30841440.865448967 1.0 1.6659638295336614 1.1233789362726563 24.71052217429559 -10.180914800556176 3.8504147256797383 0.9997248723294326 1.3946713827674266 0.4136491678955403 0.22150935575355515 54764070.63771516 97095957.69982448 183654.10637483935 0.0810641307683554 6.593032239850424e-11 10.180914800556176 0.394946510437994 ETLSGLAK(ub)NATDLQNSSMSEEELTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETLSGLAKNATDLQNSSMSEEELTK 25 1 Q5QNY5;P40855;P40855-5;H0YJ60 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 42805500.0 11229300.0 10831100.0 20745100.0 True False 10872832.018108051 15156014.713440342 15311335.970340138 1.0 1.3939344126901718 1.4082196749512936 23.374224428526453 -11.747842813080997 0.521694068577977 3.908756354882321e-16 1.4072676430728586 0.9999070561275811 0.0018236280273400086 5.3367232361823636 0.25781773770641697 5.974351153358191 0.0027966500583226864 1.7871342865043332e-12 11.747842813080997 1.4072676430728581 ETLSGLAK(ub)NATDLQNSSMSEEELTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETLSGLAKNATDLQNSSMSEEELTK 25 1 Q5QNY5;P40855;P40855-5;H0YJ60 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 91964400.0 9905400.0 41321000.0 40738000.0 True False 15027215.981740288 33946944.70755344 32686116.443900328 1.0 2.2590308643199575 2.1751278802153062 23.841074417220195 -10.146152416964 4.681900815909189 0.9998776260430304 2.2170793722806175 0.9964483262149216 0.034253249870025614 4.375800703847008e-05 7.980295711766006e-06 0.03316884166643051 0.011055188852046609 7.142456154219113e-11 10.146152416964 1.217201746237587 ETLSGLAK(ub)NATDLQNSSMSEEELTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETLSGLAKNATDLQNSSMSEEELTK 25 1 Q5QNY5;P40855;P40855-5;H0YJ60 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 38950600.0 11229300.0 14310100.0 13411200.0 True False 9337660.49233785 14233008.650967559 16215419.913617343 1.0 1.5242585294942619 1.7365613075055721 23.15462970396073 -11.111150280246951 0.17146898783782977 1.4317884256128809e-18 1.9589110598092547 0.9995214782333878 0.006771648300398839 3.3691276827873025 0.09973406240554421 1.4772965143749588 0.16537212615052338 7.74193854780804e-12 11.111150280246951 1.9589110598092547 ETLSGLAK(ub)NATDLQNSSMSEEELTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETLSGLAKNATDLQNSSMSEEELTK 25 1 Q5QNY5;P40855;P40855-5;H0YJ60 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 76210400.0 9905400.0 49297000.0 17008000.0 True False 12822735.564624852 46553578.61445427 13912718.516817119 1.0 3.630549688857774 1.0850039327956895 23.612200739312645 -6.6385162189747104 2.049576732734547 2.722184780563718 1.0955454729473226 0.14893633286695673 1.1259592377221344 0.5372006460954333 4.311018341129707 0.4476271678672599 1.2469878091451208 2.2987078611070612e-07 6.6385162189747104 -1.6266393076163954 ETLTLQK(ub)QLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETLTLQKQLR 10 1 Q9UJJ7;H3BRG3;H3BS55;H3BUN6;H3BU91 Q9UJJ7 RPUSD1 RNA pseudouridylate synthase domain-containing protein 1 1 6169300.0 1893200.0 1063500.0 3212600.0 True False 1833101.402285287 1488161.096079234 2371123.68406586 1.0 0.8118269367008156 1.293503829689854 20.805855163454993 -6.800735157862272 1.452793368431657 0.8962745845618735 1.3002840300854048 0.8343492115023732 0.08066978256739758 0.21970064205962836 0.915366657816689 0.04368070615606541 0.10154531751323119 1.582212612492676e-07 6.800735157862272 0.40400944552353135 ETLTLQK(ub)QLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETLTLQKQLR 10 1 Q9UJJ7;H3BRG3;H3BS55;H3BUN6;H3BU91 Q9UJJ7 RPUSD1 RNA pseudouridylate synthase domain-containing protein 1 1 42085000.0 1366900.0 4192100.0 36526000.0 True False 2073687.2337755945 3443987.001973202 29306620.0900855 1.0 1.660803493351638 14.132613449486536 20.98376688377061 -6.9178629213396485 0.8404225514139826 0.7030545968829166 16.04817334787663 0.9935664287707882 0.484549636528052 0.0994456752312865 0.11224982384006017 0.4128316689139397 1.2124582408746392 1.2081951239356202e-07 6.9178629213396485 15.345118750993715 up ETLTLQK(ub)QLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETLTLQKQLR 10 1 Q9UJJ7;H3BRG3;H3BS55;H3BUN6;H3BU91 Q9UJJ7 RPUSD1 RNA pseudouridylate synthase domain-containing protein 1 1 3626780.0 1068500.0 963180.0 1595100.0 True False 1463553.325126772 920623.5227896741 1218370.2321156955 1.0 0.6290331257386405 0.8324740965691572 20.481043881175662 -10.097853679184137 5.11083705740696 1.000006598223764 0.7307536111532995 0.700186075076672 0.083054428553953 6.244463020942192e-06 1.1022701620476575e-06 0.08041907540871741 0.026805701551220036 7.982635898455573e-11 10.097853679184137 -0.2692529870704645 ETLTLQK(ub)QLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETLTLQKQLR 10 1 Q9UJJ7;H3BRG3;H3BS55;H3BUN6;H3BU91 Q9UJJ7 RPUSD1 RNA pseudouridylate synthase domain-containing protein 1 1 5936400.0 1893200.0 2348100.0 1695100.0 True False 1574279.682980598 2335450.3192386418 2049537.5727431334 1.0 1.4835040714092889 1.3018891083334858 20.58626043888927 -10.290202687251755 5.0135245386899125 0.9998914897197927 1.3926965898715398 0.8617592137618025 0.07414399819888277 8.995198889045564e-05 1.2735115678507669e-05 0.07180933940897162 0.023929872520383134 5.1262208504681485e-11 10.290202687251755 0.3928051001517471 ETLTLQK(ub)QLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETLTLQKQLR 10 1 Q9UJJ7;H3BRG3;H3BS55;H3BUN6;H3BU91 Q9UJJ7 RPUSD1 RNA pseudouridylate synthase domain-containing protein 1 1 30303300.0 1366900.0 2407900.0 26528500.0 True False 1769478.995627202 2273898.248285789 21700585.205396425 1.0 1.2850665387411353 12.263827521560676 20.75489320586306 -6.912473966793104 0.8787241311201041 0.6860939724258098 13.760343404664257 0.991822052077977 0.47421820470423753 0.10280452251691294 0.1300635267750546 0.3930620132357527 1.104551652842143 1.223280444776545e-07 6.912473966793104 13.074249432238446 up ETMVTSTTEPSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETMVTSTTEPSR 12 0 K7ELL7;P14314-2;P14314;A0A0C4DGP4 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 10111000.0 2392700.0 1261300.0 6457000.0 False True 2316745.048197763 1764943.6675926072 4765717.99415217 1.0 0.7618204122053 2.057074859341776 21.14366785740317 -6.859258963917342 1.189624316595075 0.8710332303989103 2.1188670016922853 0.9527134267479692 0.12240771379838315 0.14757165020732194 0.3972891488986642 0.08028174770460285 0.18722946857646258 1.38274162299929e-07 6.859258963917342 1.247833771293375 up ETPCWIEIHLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETPCWIEIHLHR 12 0 K7EIU8;Q13485 K7EIU8 SMAD4 Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 4 0 34855000.0 10461000.0 13608000.0 10786000.0 False True 13714472.304468099 11577739.443568554 9669968.186617784 1.0 0.8441986819862249 0.7050922537841549 23.70919577649082 -6.972466930616414 0.19027096532542764 1.0939455087792354 0.4515442797885048 0.9999957714174412 0.0002476405782528371 0.07551016606491809 0.006071954422099233 0.004899722462101561 0.015152742401731499 1.0654499893425427e-07 6.972466930616414 -0.6424012289907306 ETPCWIEIHLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETPCWIEIHLHR 12 0 K7EIU8;Q13485 K7EIU8 SMAD4 Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 4 0 12301400.0 7077400.0 2641800.0 2582200.0 False True 6852731.810972889 3696684.5168050053 1905844.355660482 1.0 0.5394468394174882 0.2781145400450025 22.708247796006663 -8.95226342824193 0.19887937955273413 1.3908543352336453 2.1365606156708011e-10 0.9996042672652501 0.005936594161185618 0.43073279700625106 0.0638356808231332 0.24668360811949072 0.13817611737823404 1.1161860019894163e-09 8.95226342824193 -1.3908543350199893 down ETPCWIEIHLHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETPCWIEIHLHR 12 0 K7EIU8;Q13485 K7EIU8 SMAD4 Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 4 0 170686000.0 40646000.0 65528000.0 64512000.0 False True 61662953.6206328 53834016.42739921 51761174.92338591 1.0 0.8730366170683401 0.8394209470054692 25.8779006595889 -13.999999999999998 0.18653897125781668 1.6726617804841506 0.8144465440121287 0.9994916830954225 0.0015590343909586298 12.296411477280206 0.13695692356562816 3.003123646069676 0.023770521800124355 1.0000000000000041e-14 13.999999999999998 -0.8582152364720219 ETPCWIEIHLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETPCWIEIHLHR 12 0 K7EIU8;Q13485 K7EIU8 SMAD4 Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 4 0 44485000.0 10461000.0 17717000.0 16307000.0 False True 14328714.397895327 16934204.35771577 12455622.453207115 1.0 1.1818369664903887 0.869277041004925 23.77240583801371 -6.749003251351581 1.6534949248682784 1.1070530697276362 0.8687026754038524 0.6446258303294521 0.07640605162637422 0.3018180390139952 1.62323429467353 0.03650731358418028 0.08872418241241152 1.782365423695007e-07 6.749003251351581 -0.2383503943237838 ETPCWIEIHLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETPCWIEIHLHR 12 0 K7EIU8;Q13485 K7EIU8 SMAD4 Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 4 0 129361000.0 40646000.0 55279000.0 33436000.0 False True 52617048.25244231 52202675.0558537 27350991.082331635 1.0 0.9921247350364362 0.519812342020955 25.64902698168135 -6.910520982338857 0.8921817604510963 1.0143838715153326 0.45808926174198955 0.9911166346757384 0.021162259138677742 0.10407446481214971 0.13690685672492173 0.017370576711969513 0.0481253679707279 1.2287938176659666e-07 6.910520982338857 -0.556294609773343 ETPEHPLKQIK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETPEHPLKQIK 11 1 Q8N163;Q8N163-2;H0YB24;G3V119;E5RHJ4 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 1 15495800.0 4762200.0 4545000.0 6188600.0 True False 7224605.563454638 3733909.239752923 4965420.497440266 1.0 0.5168322626000159 0.6872929537575915 22.784487393313725 -10.04094144066 5.675053757410313 1.0000014358394067 0.6020626081786836 0.879028463655242 0.06959028575679367 1.2642007082477533e-06 2.1372457195057486e-07 0.06738074740402158 0.02246016814942791 9.100359716658109e-11 10.04094144066 -0.3979388276607231 ETPEHPLKQIK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETPEHPLKQIK 11 1 Q8N163;Q8N163-2;H0YB24;G3V119;E5RHJ4 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 1 14828800.0 4762200.0 3696100.0 6370500.0 True False 6164761.776996028 3490408.7858669744 5211134.366849919 1.0 0.5661871313327187 0.8453099333530462 22.555613715406174 -10.098897972455807 5.112939990395374 1.0000072683870447 0.7057485323422423 0.5970643119201478 0.11395140675651098 9.441499958711666e-06 1.6639665269390245e-06 0.11033569945673848 0.03677765838675286 7.963464117985411e-11 10.098897972455807 -0.29425873604480235 ETPEPVTK(ub)TEDIHLFQQQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETPEPVTKTEDIHLFQQQVK 20 1 Q5JPI3;Q5JPI3-2 Q5JPI3 C3orf38 Uncharacterized protein C3orf38 1 33376000.0 5414500.0 5692500.0 22269000.0 True False 5242619.661247454 7965544.935995333 16436080.84432009 1.0 1.5193825702969217 3.1350893077010307 22.32185645511063 -6.950632254068016 0.5518574775382997 0.9778973611142329 3.7527204699140064 0.9992499795876251 0.02489825115656291 0.08323282554213814 0.03491912781112838 0.026959930436663573 0.13408424056651894 1.1203861871820814e-07 6.950632254068016 2.7748231087997737 ETPEPVTK(ub)TEDIHLFQQQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETPEPVTKTEDIHLFQQQVK 20 1 Q5JPI3;Q5JPI3-2 Q5JPI3 C3orf38 Uncharacterized protein C3orf38 1 15908200.0 5414500.0 8048400.0 2445300.0 True False 4502396.653020517 8005041.671717685 2956600.924210246 1.0 1.777951231006569 0.6566726905828599 22.102261730544907 -6.720076328244223 1.7588654690303631 1.4732490327523686 0.6583900565877419 0.5129706783725659 0.32736103308637854 0.35516173202943296 2.1472869956884493 0.14777450633469402 0.37096053383049843 1.905125858329752e-07 6.720076328244223 -0.8148589761646268 ETPSQENGPTAK(ub)AYTGFSSNSER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETPSQENGPTAKAYTGFSSNSER 23 1 O15355 O15355 PPM1G Protein phosphatase 1G 1 13302300.0 5652500.0 3161100.0 4488700.0 True False 5473064.481522063 4423343.714918726 3312974.8118864554 1.0 0.8082023754429788 0.6053235482738393 22.38391742324288 -6.970414306784265 0.2480955276532653 1.065911592768919 0.3416866568149616 0.9999854336921637 0.0006150044346374041 0.07616856027131472 0.008547972837272847 0.004583981203402093 0.019505106519554224 1.0704975882912993e-07 6.970414306784265 -0.7242249359539573 ETQISK(ub)TNTQTYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETQISKTNTQTYR 13 1 D9J307;A0A140T953;Q2L6G2;D5H3J5;A0A140TA13;A0A140TA14;A0A140TA11;A0A140T9Y5;A0A140T997 D9J307 HLA-B 1 175753600.0 1001600.0 53952000.0 120800000.0 True False 1519500.4267683337 44323844.071099944 96923827.05147901 1.0 29.170010939297786 63.7866402299183 20.53516564938114 -7.346333728118235 0.4035799006317292 1.664401704590472e-19 80.97694228036326 0.998124544853849 1.1120048695020601 0.16177440425485873 0.0549699159837043 1.5982526191116178 6.624064176744541 4.5047041319823014e-08 7.346333728118235 80.97694228036326 ETQISK(ub)TNTQTYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETQISKTNTQTYR 13 1 D9J307;A0A140T953;Q2L6G2;D5H3J5;A0A140TA13;A0A140TA14;A0A140TA11;A0A140T9Y5;A0A140T997 D9J307 HLA-B 1 183849600.0 1001600.0 24598000.0 158250000.0 True False 1296590.944487677 23229099.67662019 129450123.78212051 1.0 17.915518981045114 99.8388306909472 20.306291971473588 -6.940518898987168 0.6547170699238269 0.08801997975652377 122.27240075705804 0.998231097179415 1.815324410055118 0.08753065862678501 0.05353735693962672 1.774111100657317 7.035009060031127 1.1467826163409528e-07 6.940518898987168 122.18438077730151 ETQK(ub)SIYYITGESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETQKSIYYITGESK 14 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 43764400.0 11595900.0 17843500.0 14325000.0 True False 15202337.194855332 15181319.353418218 12842786.4151029 1.0 0.9986174598571443 0.844790261555905 23.857789803684387 -6.908867768672478 0.9034096600404845 1.0049350163629187 0.8253846426174868 0.9904872603306075 0.007104603397885695 0.10517150575056754 0.14286337768522014 0.005784266746016372 0.01584468970038454 1.2334803386092308e-07 6.908867768672478 -0.17955037374543192 ETQK(ub)SIYYITGESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETQKSIYYITGESK 14 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 48447600.0 18577000.0 15315400.0 14555200.0 True False 17987283.30353567 21430919.088755894 10742756.47335971 1.0 1.1914483542127412 0.5972417452972489 24.1004739708409 -6.819996290816676 1.372000548616597 1.1031878850531138 0.5842814551129978 0.8843555638030063 0.08421515804819789 0.1934833524660438 0.7156717838759176 0.04823649775162702 0.11117145587593229 1.5135741753794467e-07 6.819996290816676 -0.518906429940116 ETQK(ub)SIYYITGESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETQKSIYYITGESK 14 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 47362300.0 18725800.0 17149500.0 11487000.0 True False 28408407.639355514 14089037.735344917 9216589.415069034 1.0 0.49594605632970096 0.32443175034917676 24.75981463142402 -13.999999999999998 0.15049006276739402 3.4391679755208497 0.13679103804797593 0.9995646121358274 0.0059827016471966305 11.959598238263888 0.1221992029513348 8.52909058054939 0.16920926058212415 1.0000000000000041e-14 13.999999999999998 -3.3023769374728738 ETQK(ub)SIYYITGESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETQKSIYYITGESK 14 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 43314800.0 11595900.0 13648300.0 18070600.0 True False 15883217.597414628 13045272.977107411 13802696.455689218 1.0 0.8213243253200058 0.8690113556044171 23.92099986520728 -9.977996420608083 5.169016529169383 1.0000008068608988 0.8451678404854659 0.933581116176323 0.01946814859468068 1.811507509353431e-07 3.581066831593783e-08 0.018850052129368838 0.006283317940181833 1.0519705439756248e-10 9.977996420608083 -0.15483296637543287 ETQK(ub)SIYYITGESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETQKSIYYITGESK 14 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 45603800.0 18577000.0 24895500.0 2131300.0 True False 15447598.60063941 24761383.000130128 2576944.9759822125 1.0 1.6029276549887308 0.16681848373996117 23.880879246275175 -6.792634746042241 1.4857055476119996 1.3358081397056323 0.15038393137558964 0.8098268873984806 0.2567669618826823 0.23141163117361607 1.0090081546405454 0.13601333646281477 0.31785193282317836 1.612000803555802e-07 6.792634746042241 -1.1854242083300426 ETQK(ub)SIYYITGESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETQKSIYYITGESK 14 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 45204100.0 18725800.0 18903000.0 7575300.0 True False 24240917.240702234 17851031.432927556 6196673.129141861 1.0 0.7364008240972993 0.25562865743121316 24.53094095351647 -7.058684670937511 0.43373236043606517 1.019328312729261 6.452095021664811e-11 0.9997788942686459 0.00458235876644457 0.07376016748376495 0.021219323074378182 0.0065707849353418635 0.037222592422973357 8.736054386168059e-08 7.058684670937511 -1.0193283126647399 down ETQTECEWTVDTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETQTECEWTVDTSK 14 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 9839500.0 1819700.0 3973300.0 4046500.0 False True 2385644.3219998647 3380499.1278020907 3627806.9967688564 1.0 1.4170172379125854 1.520682259008207 21.185947535602523 -12.046283585444382 0.2290162948219209 2.5460061816705648e-12 1.576644574548352 0.9993734439812996 0.005632828020769231 5.320522150448255 0.1378283907855994 2.5678134357415736 0.05397225666412676 8.989104196671411e-13 12.046283585444382 1.576644574545806 ETQTECEWTVDTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETQTECEWTVDTSK 14 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 7649000.0 1819700.0 3651900.0 2177400.0 False True 2492492.2655434576 3490546.98278163 1663142.9649606408 1.0 1.400424398918068 0.6672610334451781 21.249157597125414 -6.758404608607002 1.6184517423553504 1.2330515899272458 0.6647903318901162 0.6844145642046584 0.1683835426613946 0.28561423757934623 1.4741263757423733 0.08210226633333223 0.1976186337301951 1.7441964225567324e-07 6.758404608607002 -0.5682612580371297 ETSQTK(ub)VLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETSQTKVLK 9 1 M0R0N4;M0QYZ2;P53680;X6R390;P53680-2;M0QZ21;M0R1S0 M0R0N4 AP2S1 AP-2 complex subunit sigma 1 4080330.0 1167900.0 977930.0 1934500.0 True False 1531128.20995969 832026.6559412827 1734336.4970343173 1.0 0.5434075673931887 1.1327180086897994 20.546163662174038 -6.699886314701877 1.831472063924844 0.716434974339615 1.1309481523280023 0.4169059396481892 0.19273845938660733 0.39578171718305927 2.5809499860629943 0.08396195248021375 0.21594248785608142 1.9957846832974394e-07 6.699886314701877 0.41451317798838727 ETSQTK(ub)VLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETSQTKVLK 9 1 M0R0N4;M0QYZ2;P53680;X6R390;P53680-2;M0QZ21;M0R1S0 M0R0N4 AP2S1 AP-2 complex subunit sigma 1 4257300.0 659200.0 1290600.0 2307500.0 True False 638274.0568278373 1805943.3103900882 1703096.5264838364 1.0 2.8294167545606643 2.6682841144258123 19.283816483899848 -10.153998889406129 4.838147298273204 0.9998588524695822 2.7488504345010885 0.9936734541119047 0.06578212490004338 0.00010016075322319552 1.7513976745538024e-05 0.06369824701497055 0.021231089514149287 7.014570922096322e-11 10.153998889406129 1.7489915820315063 ETSQTK(ub)VLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETSQTKVLK 9 1 M0R0N4;M0QYZ2;P53680;X6R390;P53680-2;M0QZ21;M0R1S0 M0R0N4 AP2S1 AP-2 complex subunit sigma 1 4278980.0 1167900.0 822080.0 2289000.0 True False 1599704.1913107713 785757.7873449781 1748385.3434347864 1.0 0.49118942840372326 1.0929429034015272 20.60937372369693 -6.6825789744166 1.8925669209776637 0.6788206184932729 1.0907092883697307 0.33602784512547024 0.21552502508805788 0.4328243633484047 2.9994775250504784 0.09130099086374946 0.24002141574356284 2.0769260119672657e-07 6.6825789744166 0.4118886698764578 ETSQTK(ub)VLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETSQTKVLK 9 1 M0R0N4;M0QYZ2;P53680;X6R390;P53680-2;M0QZ21;M0R1S0 M0R0N4 AP2S1 AP-2 complex subunit sigma 1 4334000.0 659200.0 1117700.0 2557100.0 True False 548154.0075115204 1111678.7282539194 3091777.7873054543 1.0 2.028040866289855 5.640345130999476 19.064221759334124 -6.947853969046012 0.5819268925744856 0.9571250618588167 6.89052376050021 0.9990219352253639 0.06223314241770349 0.08435909319557922 0.0396181778238093 0.06506893938070304 0.30191662782262924 1.1275765385816891e-07 6.947853969046012 5.933398698641394 ETSSALTHAGAHLDLSAFSSWEELASLGLDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETSSALTHAGAHLDLSAFSSWEELASLGLDR 31 0 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 0 55504000.0 12787000.0 27080000.0 15637000.0 False True 19398813.854918823 22247362.422994275 12546340.096059443 1.0 1.1468413785182625 0.6467581054126232 24.209465105389786 -6.828112303593044 1.3365768211592037 1.07856797273455 0.6338365164904863 0.9019942758767067 0.06570300903172929 0.18315605553984737 0.6406139603918662 0.038606452120969956 0.08884227997407838 1.4855514459769664e-07 6.828112303593044 -0.44473145624406374 ETSVSK(ub)EDTDHEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETSVSKEDTDHEEK 14 1 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 4309510.0 1389500.0 2080700.0 839310.0 True False 1821647.9559371397 1770267.670505078 752466.252430018 1.0 0.9717946130784478 0.4130689741547316 20.79681274619352 -6.917382524236934 0.8439123837832249 1.013528998956924 0.328179335660653 0.9934223570867593 0.021920368714352444 0.09973663043383536 0.11377572220304519 0.018629365694242644 0.054480760943483315 1.2095323146974671e-07 6.917382524236934 -0.685349663296271 down ETSVSK(ub)EDTDHEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETSVSKEDTDHEEK 14 1 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 1 3862020.0 2139900.0 1265800.0 456320.0 True False 1779421.66364366 1258980.8841583724 551734.4022147057 1.0 0.7075225113199988 0.3100638895701305 20.762976991095478 -7.069889887941838 0.34292644885143375 1.0447550913017292 3.931267374896994e-11 0.9999267748506537 0.002419533135280398 0.07394267769162526 0.014445426651110886 0.006124101479404803 0.033330486751742855 8.513538651289056e-08 7.069889887941838 -1.0447550912624164 down ETSVTPSNLWGGQGLLGVSIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETSVTPSNLWGGQGLLGVSIR 21 0 Q9H8Y8-3;Q9H8Y8;Q9H8Y8-2 Q9H8Y8-3 GORASP2 Golgi reassembly-stacking protein 2 0 23907400.0 11905000.0 6741100.0 5261300.0 False True 11527082.291467544 9432856.384372087 3883207.694383279 1.0 0.8183212495458957 0.33687689531440806 23.45852405176169 -6.954201442798792 0.5106411287765004 1.0088140746984593 0.12523930307155082 0.9994910794181026 0.006311792701195328 0.08184125518907992 0.029310228259954153 0.007261929848591467 0.039736470417351365 1.1112161821168835e-07 6.954201442798792 -0.8835747716269085 down ETSVTPSNLWGGQGLLGVSIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETSVTPSNLWGGQGLLGVSIR 21 0 Q9H8Y8-3;Q9H8Y8;Q9H8Y8-2 Q9H8Y8-3 GORASP2 Golgi reassembly-stacking protein 2 0 61045000.0 13826000.0 26947000.0 20272000.0 False True 20975052.815993432 22138097.31212801 16265230.314466778 1.0 1.0554489424335447 0.7754559884619016 24.322171107643065 -6.8552488746185505 1.2094096861101484 1.0297828713032922 0.7630713272227104 0.947608525224802 0.027708694012558092 0.15177939238315843 0.4245686744419945 0.017899960370898815 0.04158762319283793 1.3955683944376878e-07 6.8552488746185505 -0.26671154408058173 ETSVTPSNLWGGQGLLGVSIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETSVTPSNLWGGQGLLGVSIR 21 0 Q9H8Y8-3;Q9H8Y8;Q9H8Y8-2 Q9H8Y8-3 GORASP2 Golgi reassembly-stacking protein 2 0 4761080.0 839980.0 1485500.0 2435600.0 False True 1150543.3056059764 1419865.698108413 1860361.4427565588 1.0 1.234082794789361 1.6169416950166255 20.133883855891114 -6.963779677280055 0.3784161482623282 0.9732284421264432 1.8913008602272092 0.9998857312768964 0.0027183178648547885 0.07837759145618314 0.016335588757090097 0.004990964130330129 0.03237600415917939 1.086976919995016e-07 6.963779677280055 0.918072418100766 ETSVTPSNLWGGQGLLGVSIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETSVTPSNLWGGQGLLGVSIR 21 0 Q9H8Y8-3;Q9H8Y8;Q9H8Y8-2 Q9H8Y8-3 GORASP2 Golgi reassembly-stacking protein 2 0 20862100.0 11905000.0 3264700.0 5692400.0 False True 9899534.980923321 3247112.4131077896 6882654.521316159 1.0 0.3280065598399385 0.695250285450703 23.238929327195965 -10.696457712539376 6.896755553960716 1.003938160607142 0.511628422645716 0.702197398075193 0.1499266231641746 0.009116117363878486 0.000401221031225557 0.14576572458438147 0.0483886095556636 2.0116030594135354e-11 10.696457712539376 -0.4923097379614261 ETSVTPSNLWGGQGLLGVSIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETSVTPSNLWGGQGLLGVSIR 21 0 Q9H8Y8-3;Q9H8Y8;Q9H8Y8-2 Q9H8Y8-3 GORASP2 Golgi reassembly-stacking protein 2 0 48752000.0 13826000.0 16363000.0 18563000.0 False True 17898029.551204726 15452384.665766995 15184724.472464498 1.0 0.8633567522927063 0.8484020226373135 24.093297429735514 -13.999999999999996 0.31240585762939016 2.3395949970339447 0.8451748409418145 0.9996772648947632 0.0012254190990270625 17.443300871404837 0.17793769339244245 15.20972064596348 0.0051319208069728 1.0000000000000082e-14 13.999999999999996 -1.4944201560921302 ETTDTDTADQVIASFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETTDTDTADQVIASFK 16 0 O43707;O43707-2;O43707-3;F5GXS2;H7C144 O43707 ACTN4 Alpha-actinin-4 0 8585900.0 2416000.0 1065300.0 5104600.0 False True 2339305.4024515375 1490679.8454661097 3767552.1252825097 1.0 0.6372318227042574 1.6105430788704216 21.15764879092907 -6.805761144325885 1.4321327108803565 0.8012763663280684 1.62599113424756 0.84849679616754 0.15632478967330582 0.2126441130807756 0.8603114167393043 0.08584597572017535 0.19900083330868878 1.5640075876585537e-07 6.805761144325885 0.8247147679194915 ETTYYDVLGVK(ub)PNATQEELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETTYYDVLGVKPNATQEELK 20 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 13751000.0 2627100.0 5188700.0 5935200.0 True False 3444153.5408725874 4414566.185394184 5321082.438458557 1.0 1.281756499240083 1.5449608663818293 21.715718029050176 -6.971945841667203 0.2064857137379129 0.8558659973353105 1.9781702747476781 0.9999938450251765 0.0005520303443106571 0.075676209629058 0.006721278367076893 0.008106213083051738 0.027500531194745687 1.0667291385077562e-07 6.971945841667203 1.1223042774123675 ETTYYDVLGVK(ub)PNATQEELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETTYYDVLGVKPNATQEELK 20 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 31375300.0 4505100.0 6057200.0 20813000.0 True False 4362088.066467064 8475871.547880715 15361450.923383798 1.0 1.9430766684968557 3.521582024322888 22.0565874662567 -6.9633716212850105 0.3849776549209687 0.8974609376872973 4.623461580100765 0.9998755439654841 0.01160523282083562 0.07851796617496754 0.016835789119293475 0.020449761667851372 0.1330735510270495 1.0879987056897755e-07 6.9633716212850105 3.7260006424134673 ETTYYDVLGVK(ub)PNATQEELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETTYYDVLGVKPNATQEELK 20 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 18544500.0 2627100.0 4150400.0 11767000.0 True False 3598409.8647080404 3967021.6044625724 8987876.948972097 1.0 1.1024373969651842 2.497735746314528 21.778928090573068 -6.921647756727167 0.8124175119276604 0.9710040108803123 2.7314910247442787 0.9946264474301526 0.050079877589881173 0.09721181307766509 0.10066287004361361 0.043529794679041146 0.1325180671189034 1.1977115655157529e-07 6.921647756727167 1.7604870138639663 up ETTYYDVLGVK(ub)PNATQEELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETTYYDVLGVKPNATQEELK 20 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 27954200.0 4505100.0 9071100.0 14378000.0 True False 3746190.2597696455 9022232.18382762 17384373.323639188 1.0 2.4083753248513333 4.640547360962963 21.836992741690977 -6.964325785163394 0.36944056489667787 0.8272519923085723 6.2993010323160945 0.9998985659696777 0.015095861001752324 0.07819050515360931 0.01567119584933413 0.02944695921117355 0.18963411156615753 1.0856109491438005e-07 6.964325785163394 5.472049040007522 ETTYYDVLGVK(ub)PNATQEELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETTYYDVLGVKPNATQEELK 20 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 29367400.0 5268400.0 12643000.0 11456000.0 True False 6820047.655689777 11939405.935909793 9371125.548486408 1.0 1.7506337988634253 1.3740557282863466 22.7013503895688 -10.23581772705686 4.67473773149523 0.9998494603332233 1.5623447635772547 0.7483179824232797 0.15373735354738535 0.00024127060365554092 3.9440283015713074e-05 0.14889499978984783 0.049618517497104477 5.8100821490153065e-11 10.23581772705686 0.5624953032440314 ETTYYDVLGVK(ub)PNATQEELKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETTYYDVLGVKPNATQEELKK 21 2 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 73564600.0 5242600.0 35137000.0 33185000.0 True False 5076176.532654157 49167387.337034315 24492852.97133962 1.0 9.685909664636188 4.825059336250695 22.2753108115442 -9.4044333008725 11.183080050562532 0.9999998185396972 7.255484500443442 0.6882976171219854 1.984433836764088 0.0 0.0 1.9214198003594485 0.6404732667864826 3.9406394350225025e-10 9.4044333008725 6.255484681903745 ETTYYDVLGVK(ub)PNATQEELKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETTYYDVLGVKPNATQEELKK 21 2 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 130818000.0 71971000.0 31881000.0 26966000.0 True False 109185268.78488798 26191586.462610092 21636158.28038231 1.0 0.23988205326683404 0.19816004962179393 26.702202980882106 -13.511114790220445 0.4178873459376738 9.999886260426187 0.196650134704762 0.999853455912644 0.00446150271699425 19.325031390439378 0.21477246916340006 156.31627161683625 0.010181640518904097 3.082373127426774e-14 13.511114790220445 -9.803236125721426 ETTYYDVLGVK(ub)PNATQEELKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETTYYDVLGVKPNATQEELKK 21 2 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 127838300.0 20327000.0 33229300.0 74282000.0 True False 27842441.216520242 31761119.65139944 56738121.485811606 1.0 1.140744786148783 2.0378285454418483 24.73078237599308 -6.934569736651166 0.7082800658701721 0.9883937907260302 2.245432752781068 0.9973626016462428 0.023606555837536222 0.09033341246367622 0.06655893288959984 0.02212466483172613 0.07923039980836445 1.1625998520389157e-07 6.934569736651166 1.2570389620550375 up ETTYYDVLGVK(ub)PNATQEELKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETTYYDVLGVKPNATQEELKK 21 2 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 28563600.0 5242600.0 12105000.0 11216000.0 True False 4359454.186559311 12039787.962345626 13561213.743075341 1.0 2.761764993302522 3.1107595498734892 22.055716086978475 -10.113755336969735 0.37555508784923874 2.65718847085589e-22 3.1624061098867466 0.9989445086313533 0.030013225558677886 1.4797616113306853 0.17057260161813803 1.6748301899952818 0.09512808432444193 7.695638577203235e-11 10.113755336969735 3.1624061098867466 ETTYYDVLGVK(ub)PNATQEELKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ETTYYDVLGVKPNATQEELKK 21 2 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 129072000.0 71971000.0 27703000.0 29398000.0 True False 93167878.26050584 26161303.697105814 24047865.648952823 1.0 0.2807974613735051 0.25811326927197814 26.473329302974555 ETTYYDVLGVKPNATQEELKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETTYYDVLGVKPNATQEELKK 21 2 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 159350500.0 27993000.0 7797500.0 123560000.0 True False 27104377.53759352 10911082.413425311 91195929.27945516 1.0 0.40255794099280606 3.3646199457252703 24.692022539471726 -6.854212790920599 1.214484209554934 0.679610931085465 3.49308088260785 0.9462222444297154 0.2965965408702952 0.15288858494774202 0.4318220474201679 0.19086242130221973 0.4430545171171427 1.398901735861377e-07 6.854212790920599 2.813469951522385 up ETVFTK(ub)SPYQEFTDHLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETVFTKSPYQEFTDHLVK 18 1 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 11277500.0 4084900.0 3478000.0 3714600.0 True False 5355343.458227873 2959095.9571378157 3330248.8249592497 1.0 0.5525501735264996 0.6218553209398182 22.352547672701657 -10.644597922777024 6.604089317872619 1.0018562212345785 0.587202747233185 0.9792970088698493 0.028293707951833343 0.0007761335921696481 4.176792487394014e-05 0.02749651228873179 0.009131754974992244 2.2667419246919297e-11 10.644597922777024 -0.4146534740013935 ETVFTK(ub)SPYQEFTDHLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETVFTKSPYQEFTDHLVK 18 1 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 15454400.0 5655900.0 4502800.0 5295700.0 True False 5476356.550383134 6300791.52179179 3908597.302405402 1.0 1.1505444292795322 0.7137222104597902 22.384784948849834 -6.81364992767031 1.3990631902345232 1.0816997325841646 0.7054200760464766 0.8691566307789138 0.06553654667619857 0.20186805566335908 0.7780360730033972 0.03682503169565407 0.08505478110258886 1.535854492241738e-07 6.81364992767031 -0.376279656537688 ETVFTK(ub)SPYQEFTDHLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETVFTKSPYQEFTDHLVK 18 1 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 12862000.0 4084900.0 3509000.0 5268100.0 True False 5595197.920271739 3353960.7772887396 4023883.279925208 1.0 0.599435591927345 0.7191672818840664 22.41575773422455 -10.556129764691983 9.39064830831033 1.000023128157045 0.6593014369057068 0.9152251846133426 0.04888025773918081 2.367013691691435e-05 1.118850783634074e-06 0.04733130672288172 0.015776035348514444 2.7788828295024044e-11 10.556129764691983 -0.34072169125133833 ETVFTK(ub)SPYQEFTDHLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETVFTKSPYQEFTDHLVK 18 1 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 14310900.0 5655900.0 5035800.0 3619200.0 True False 4703131.448853771 5008671.1458719615 4375957.986709902 1.0 1.0649651621139902 0.930434973867548 22.16519022428411 -6.77539059802695 1.553746487607987 1.0370054111555211 0.9295179309238666 0.7507594373128503 0.027424459980802493 0.2578089652755574 1.2289395609406577 0.013906532906455694 0.03294338952478495 1.6772948054281913e-07 6.77539059802695 -0.10748748023165455 ETVSEESNVLCLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETVSEESNVLCLSK 14 0 P13639 P13639 EEF2 Elongation factor 2 0 120238000.0 14883000.0 54040000.0 51315000.0 False True 19511757.12717702 45977442.6462701 46005416.048237756 1.0 2.356396830208093 2.3578304992408374 24.217840369606794 ETVSEESNVLCLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETVSEESNVLCLSK 14 0 P13639 P13639 EEF2 Elongation factor 2 0 54406800.0 26285000.0 4793800.0 23328000.0 False True 25450597.06268156 6707989.339336742 17217696.975001078 1.0 0.263569036231874 0.676514461825634 24.60119616606323 -10.400215445321239 5.884878475555018 1.000156524542227 0.4700417490320728 0.6871110629645746 0.1685842640535265 0.00034630997748435696 3.529621024329917e-05 0.163278481062258 0.05441033725932822 3.979097260548559e-11 10.400215445321239 -0.5301147755101543 ETVSEESNVLCLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETVSEESNVLCLSK 14 0 P13639 P13639 EEF2 Elongation factor 2 0 114145060.0 14883000.0 47583060.0 51679000.0 False True 20385647.297952037 45480683.07306259 39473484.562414326 1.0 2.231014910065261 1.936337070168965 24.281050431129685 -10.592785624290837 6.299330043308778 0.9970506813282786 2.083675990117113 0.9474567752981347 0.12030172437524674 0.004987385181141539 0.0003224044300230082 0.11658445896082568 0.03882721458544712 2.5539616738154147e-11 10.592785624290837 1.0866253087888347 ETVSEESNVLCLSK(ub)SPNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ETVSEESNVLCLSKSPNK 18 1 P13639 P13639 EEF2 Elongation factor 2 1 17588300.0 4236900.0 7116200.0 6235200.0 True False 5554616.930197967 6054490.698730348 5590041.316261753 1.0 1.0899924827965706 1.006377466980882 22.405255990036668 -10.907412434599797 4.207926860428869 0.9803523807398291 1.048184974888731 0.30689630509117527 0.034135687263879846 0.008587409149443651 0.00018894978509330804 0.045109520485527514 0.011017245690360375 1.2376207022637797e-11 10.907412434599797 0.06783259414890197 ETVSEESNVLCLSK(ub)SPNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETVSEESNVLCLSKSPNK 18 1 P13639 P13639 EEF2 Elongation factor 2 1 13393600.0 6586400.0 4067300.0 2739900.0 True False 6377318.337213077 5691394.100689292 2022237.9947618914 1.0 0.8924431555311794 0.31709848682975117 22.60451846746637 -6.938310989940234 0.6750927848635091 1.006685589040013 0.16936283294666812 0.9979342142272801 0.013626386225981392 0.08854567592271283 0.058182170965105945 0.013100306932859913 0.04989849803720056 1.1526275877474702e-07 6.938310989940234 -0.8373227560933449 down ETVSEESNVLCLSK(ub)SPNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ETVSEESNVLCLSKSPNK 18 1 P13639 P13639 EEF2 Elongation factor 2 1 55919400.0 11955000.0 8961400.0 35003000.0 True False 18136609.02757135 7362168.154262225 28084641.70764012 1.0 0.40592859134087445 1.5485056586347385 24.112401406934875 -6.765398388382439 1.5920381819405474 0.6572598900749751 1.5538493418825563 0.712668973376579 0.2501014597113646 0.27393268758699757 1.369472961186391 0.12388014814822665 0.2961520455699023 1.71633323259672e-07 6.765398388382439 0.8965894518075812 ETVSEESNVLCLSK(ub)SPNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ETVSEESNVLCLSKSPNK 18 1 P13639 P13639 EEF2 Elongation factor 2 1 17224600.0 4236900.0 5739400.0 7248300.0 True False 5803396.427917289 5485814.330342253 5536400.823424357 1.0 0.9452765115187884 0.9539932162468607 22.46846605155956 -10.326374416250559 5.211391249111529 1.0000155454330373 0.9496348638836491 0.9780285566400874 0.003558579803729239 6.429383516549732e-07 8.310939994121112e-08 0.003446643449386625 0.0011485266929972312 4.7165623916570936e-11 10.326374416250559 -0.05038068154938813 ETVSEESNVLCLSK(ub)SPNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETVSEESNVLCLSKSPNK 18 1 P13639 P13639 EEF2 Elongation factor 2 1 14066900.0 6586400.0 2540900.0 4939600.0 True False 5476883.426993132 2527211.6673708386 5972447.52187009 1.0 0.4614324370891906 1.0904828633807582 22.384923742900646 -6.680057918005848 1.9020163366859204 0.6592568142255485 1.0880723337330294 0.32429500927040134 0.22825501958447095 0.43836176828172346 3.0662233748644088 0.09630073365184245 0.2539367191164383 2.0890175185251883e-07 6.680057918005848 0.42881551950748087 ETVVEVPQVTWEDIGGLEDVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ETVVEVPQVTWEDIGGLEDVKR 22 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 65176000.0 11709000.0 10337000.0 43130000.0 True False 11337304.204182547 14464618.006742876 31832959.12773474 1.0 1.2758428058591393 2.8078067373362847 23.434574299764098 -6.937491788359825 0.6824960871570335 0.9818309868589011 3.192132666760517 0.9978166146845546 0.037157341445334335 0.0889297033550417 0.059960947878021295 0.035516290999651756 0.13337541195660002 1.154803819513946e-07 6.937491788359825 2.2103016799016157 up ETVVEVPQVTWEDIGGLEDVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ETVVEVPQVTWEDIGGLEDVKR 22 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 50091000.0 11709000.0 11616000.0 26766000.0 True False 9736552.296651067 11553422.30240454 32362646.8479988 1.0 1.1866030141263035 3.3238302288100567 23.214979575198374 -6.9240779072200835 0.7939000695186123 0.9594074719960453 3.7030151441766854 0.9952407244864029 0.0727292026786105 0.09583123122917264 0.09361434069039117 0.0640574464265383 0.20004666207029334 1.1910283326677203e-07 6.9240779072200835 2.74360767218064 up EVAEAYEVLSDKHK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVAEAYEVLSDKHK 14 1 P25686;C9JRD2;P25686-2;C9JXB9;C9J1G2;E7ETU0;C9JX00 P25686 DNAJB2 DnaJ homolog subfamily B member 2 1 33019100.0 7687500.0 17288000.0 8043600.0 True False 11662499.531531125 14202821.328239491 6453778.934364884 1.0 1.2178196697749284 0.5533787089908326 23.47537368733721 -6.818389536755874 1.378754616870978 1.1176003551473541 0.5393602341029968 0.88064900047994 0.09554577868890471 0.19558702983359016 0.7309952615361381 0.05446152582555497 0.12558663157112074 1.5191842989694573e-07 6.818389536755874 -0.5782401210443573 EVALVK(ub)DVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVALVKDVR 9 1 P27816-6;P27816;E7EVA0;P27816-2;P27816-5;H7C456 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 1 3264940.0 1125300.0 1167000.0 972640.0 True False 1475279.1974207019 992888.1489303719 872000.5430216887 1.0 0.6730171147714166 0.59107492639105 20.492556580488223 -13.999999998969482 0.19434132313888403 2.7799181705420577 0.5347892528898629 0.9994876013168079 0.003998720883464795 12.42465733015604 0.13979932746273038 8.38740399149895 0.054466891611025504 1.0000000023728551e-14 13.999999998969482 -2.245128917652195 EVCFTIENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVCFTIENK 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 63481000.0 16255000.0 19848000.0 27378000.0 False True 21310462.413643923 16886755.766898047 24545187.188320205 1.0 0.7924162056702431 1.151790454467345 24.345058562570678 -6.750057942411942 1.649428069999092 0.877950316372372 1.1525173325327984 0.64932997599379 0.08722848124673764 0.29993045004324964 1.6054530728267336 0.041774271174980386 0.10141852027331187 1.7780421725670928e-07 6.750057942411942 0.27456701616042645 EVCFTIENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVCFTIENK 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 17950300.0 6453600.0 3155300.0 8341400.0 False True 6248734.000522041 4415227.744672124 6156537.103363937 1.0 0.7065795638449742 0.9852455077859928 22.57513249731066 -10.593062956871991 8.76479219175465 1.000041787721282 0.8459125359296951 0.2896047154223531 0.11376489522441953 9.292187772163531e-05 4.314175657826299e-06 0.11018218097948657 0.03671746204893405 2.5523312808261798e-11 10.593062956871991 -0.15412925179158687 EVCFTIENK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVCFTIENK 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 95569000.0 16255000.0 17510000.0 61804000.0 False True 22264912.77485792 16736350.302173203 47207168.093334846 1.0 0.751691707549481 2.120249406350351 24.40826862409357 -6.859933382766835 1.1861217747985664 0.8653093945837399 2.1864217249719498 0.9535559080493601 0.1282950126227687 0.14686844724754522 0.39267588311730467 0.08436663104228549 0.19691562381802263 1.3805960205366151e-07 6.859933382766835 1.32111233038821 up EVCFTIENK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVCFTIENK 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 25368400.0 6453600.0 2521800.0 16393000.0 False True 5366454.342955624 2508214.562861891 19820700.507331826 1.0 0.46738766466062376 3.693444356486483 22.355537772744935 -6.864513162279787 1.1628118808580956 0.7068005103590582 3.8636138060911547 0.958888835830302 0.2863120078646201 0.14221955939886002 0.36289207408472884 0.19166850691675205 0.4499098655472427 1.3661136718881472e-07 6.864513162279787 3.1568132957320962 up EVCFTIENK(ub)TPQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVCFTIENKTPQGR 14 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 15190800.0 4496900.0 5977600.0 4716300.0 True False 5895479.448041552 5085765.380502297 4228302.517944138 1.0 0.8626550945219158 0.7172109673537677 22.49117771402796 -6.970399527399929 0.24845858910663135 1.0470412609676751 0.5285732648790413 0.9999853307570531 0.0004421942994757403 0.07617325282338278 0.008565032093725552 0.003278122775670011 0.013974816123584944 1.0705340187898594e-07 6.970399527399929 -0.5184679960886338 EVCFTIENK(ub)TPQGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVCFTIENKTPQGR 14 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 36907400.0 8380400.0 10328000.0 18199000.0 True False 12713679.48930647 8484887.706967678 14601959.673094925 1.0 0.6673825397363803 1.148523500641706 23.599878288004227 -6.72073394848968 1.7567823289734508 0.7977990717833708 1.1477996769335548 0.5159569612928663 0.13995385951560133 0.3538799849352721 2.1348812883059627 0.06324695931316404 0.15863015712826453 1.9022432491406857e-07 6.72073394848968 0.35000060515018394 EVCFTIENK(ub)TPQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVCFTIENKTPQGR 14 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 15303300.0 4496900.0 5614200.0 5192200.0 True False 6159525.4541531 5366146.080323292 3965909.296715635 1.0 0.8711947243768808 0.6438660455638826 22.55438777555085 -6.962414664663854 0.39995018671254445 1.0125034137736755 0.4942573838216812 0.9998495362681502 0.0018060162569020757 0.07884957876140265 0.01802502662965446 0.0029250589302742503 0.01904677435570079 1.0903987258247363e-07 6.962414664663854 -0.5182460299519942 EVCFTIENK(ub)TPQGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVCFTIENKTPQGR 14 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 9250100.0 3512800.0 2000700.0 3736600.0 True False 2921048.8434260758 1989921.8319921435 4517905.783913636 1.0 0.6812353844991443 1.5466724543416461 21.478055051277448 -6.806970652932371 1.4270024147482345 0.8256461538270606 1.5608214611626143 0.851845794125004 0.13755597276858775 0.21094734551303332 0.8471374974974895 0.0758051465567245 0.1756241094231997 1.5596578917763635e-07 6.806970652932371 0.7351753073355537 EVCFTIENK(ub)TPQGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVCFTIENKTPQGR 14 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 31969100.0 8380400.0 9800700.0 13788000.0 True False 10848593.002380732 9255282.429492304 11278725.476827053 1.0 0.8531320538489392 1.0396486875627031 23.371004610096676 -6.696775636395044 1.8425399569778165 0.9085120702093473 1.0390579694944637 0.4021783399854104 0.06203243524526446 0.40228630879627814 2.6529266319558604 0.02688300440584088 0.06940810891635757 2.010131010840198e-07 6.696775636395044 0.1305458992851164 EVDATSPAPSTSSTVK(ub)TEGAEATPGAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVDATSPAPSTSSTVKTEGAEATPGAQK 28 1 Q16666;Q16666-2;Q16666-3;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 11234100.0 4417000.0 3495700.0 3321400.0 True False 5790729.774288853 2974155.186131878 2977733.389118518 1.0 0.5136062814288598 0.5142242006076354 22.465313744033114 -9.985034886900126 5.154727130098652 1.000002786155605 0.5139152410156548 0.9999987873721116 0.0002522644626955705 8.262497781962488e-09 1.6268357105688497e-09 0.00024425543959040875 8.141800316207164e-05 1.035059016990705e-10 9.985034886900126 -0.4860875451399501 EVDATSPAPSTSSTVK(ub)TEGAEATPGAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVDATSPAPSTSSTVKTEGAEATPGAQK 28 1 Q16666;Q16666-2;Q16666-3;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 55692800.0 4981500.0 6063300.0 44648000.0 True False 4823365.009235243 8484407.309691781 32953349.38871091 1.0 1.7590224445893647 6.832024805424324 22.201608559827857 -6.93359675147381 0.716652377097056 0.9321942550019637 7.975773458251036 0.9971991401092938 0.13701541662131214 0.09081282793228065 0.06884287635115709 0.12761440860159698 0.45028654403908835 1.1652074387533431e-07 6.93359675147381 7.043579203249072 EVDATSPAPSTSSTVK(ub)TEGAEATPGAQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVDATSPAPSTSSTVKTEGAEATPGAQK 28 1 Q16666;Q16666-2;Q16666-3;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 206589800.0 6158800.0 15131000.0 185300000.0 True False 9343349.868591068 12430754.830957418 148675373.78012472 1.0 1.3304387618775873 15.912427113525638 23.155508461051642 -6.911783872394707 0.8834896317071349 0.5735844792333307 17.870681443319548 0.9915777261022193 0.6381164978002283 0.10325042502994856 0.13245266988748072 0.527086597427317 1.4736430091758332 1.2252257838813614e-07 6.911783872394707 17.297096964086215 up EVDATSPAPSTSSTVK(ub)TEGAEATPGAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVDATSPAPSTSSTVKTEGAEATPGAQK 28 1 Q16666;Q16666-2;Q16666-3;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 12206500.0 4417000.0 3876400.0 3913100.0 True False 6050084.264936791 3705127.830459405 2988906.372824232 1.0 0.6124092935254539 0.49402723035551954 22.528523805556006 -13.999999999999998 0.1661371607152275 2.9356584866212234 0.385187537164566 0.9995215851646035 0.004726441058178245 12.056270370094477 0.12898835260226457 7.519031493826824 0.1000185544529099 1.0000000000000041e-14 13.999999999999998 -2.5504709494566575 EVDATSPAPSTSSTVK(ub)TEGAEATPGAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVDATSPAPSTSSTVKTEGAEATPGAQK 28 1 Q16666;Q16666-2;Q16666-3;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 45704400.0 4981500.0 7109900.0 33613000.0 True False 4142337.9678680827 7071597.557495353 40641322.891047694 1.0 1.7071512784203984 9.811204012396017 21.982013835262133 -6.924069567414299 0.793968357268158 0.8460272256898625 11.248711404529036 0.9952385689168209 0.27583326790651663 0.0958361238409242 0.09363944789790324 0.24293265360480126 0.758586728715942 1.1910512043383601e-07 6.924069567414299 10.402684178839174 up EVDATSPAPSTSSTVK(ub)TEGAEATPGAQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVDATSPAPSTSSTVKTEGAEATPGAQK 28 1 Q16666;Q16666-2;Q16666-3;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 462471800.0 6158800.0 11323000.0 444990000.0 True False 7972688.008097748 10692865.096283058 364006385.98297566 1.0 1.341186947918 45.656670073287636 22.92663478314409 -6.905905242487828 0.924177702215645 3.594826626976969e-15 50.889867614287546 0.9904517448342077 2.0492240121838967 0.10338737762379879 0.14888744022712677 1.6723272129550582 4.489896628173558 1.2419232498332017e-07 6.905905242487828 50.88986761428754 up EVDCCTTLQLSNGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVDCCTTLQLSNGKR 15 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 38825200.0 14655000.0 15279000.0 8891200.0 True False 19212846.91922186 12999432.757075517 7971223.914412779 1.0 0.6766010686354861 0.41489030480109723 24.19556797456986 -7.436622059304381 0.19264563731417544 1.2056262111012142 1.1494822623169525e-12 0.9999666401609396 0.0013822065103029106 0.12404199789489351 0.015811387057198655 0.028525704642932814 0.06006102448063472 3.659130855242942e-08 7.436622059304381 -1.2056262111000646 down EVDCCTTLQLSNGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVDCCTTLQLSNGKR 15 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 113106600.0 39107000.0 27428000.0 46571600.0 True False 59328178.104661874 22533259.10405788 37366702.84694262 1.0 0.37980702971034375 0.6298306140637484 25.822214144300407 -10.312122128169905 5.738980532862379 1.0000558529882 0.5048188218870696 0.8394873957246558 0.1020717008879358 7.295208477514176e-05 8.743699671600426e-06 0.09884159375927862 0.03294349980483509 4.873914112461444e-11 10.312122128169905 -0.4952370311011304 EVDCCTTLQLSNGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVDCCTTLQLSNGKR 15 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 33623800.0 14655000.0 10157000.0 8811800.0 True False 20073349.53648369 9708230.15529259 6730634.324717619 1.0 0.48363777742462455 0.3353020039074478 24.258778036092753 -13.999999999999998 0.17491993810281972 3.639263823917096 0.21107827160194412 0.9995051539899 0.006337396671199938 12.143233043285026 0.13252542266724043 10.881601188302104 0.11572661957515121 1.0000000000000041e-14 13.999999999999998 -3.428185552315152 EVDCCTTLQLSNGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVDCCTTLQLSNGKR 15 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 81335000.0 39107000.0 17797000.0 24431000.0 True False 50624782.41421692 16806581.30517967 19984808.683228996 1.0 0.3319832798028953 0.39476334969129023 25.593340466392856 -10.19198205564054 5.647263530027183 1.000017409824799 0.363373314747062 0.9927593230461227 0.02562985620724773 5.618147660379867e-06 8.03820530923122e-07 0.02481667883349675 0.008272000521347633 6.427142727031882e-11 10.19198205564054 -0.6366440950777369 EVDEQMLNVQNK ddPTM_RPMI8226_Bortezomib_1h_R1 2 EVDEQMLNVQNK 12 0 P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P07437;P68371;Q13885;Q9BVA1 TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 278365400.0 14484300.0 146233600.0 117647500.0 False True 18989057.56616071 124416116.89410834 105474465.2545074 1.0 6.551990084848815 5.5544865713855796 24.17866496999565 -9.825622744533472 6.3724404777346 0.9999998434354685 6.053238328118534 0.9716050993173355 0.40722910410785823 9.567632966461268e-07 1.770272219009845e-07 0.3942979080726424 0.13143262819101897 1.4940917079466133e-10 9.825622744533472 5.053238484683065 EVDEQMLNVQNK ddPTM_RPMI8226_Bortezomib_2h_R1 2 EVDEQMLNVQNK 12 0 P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P07437;P68371;Q13885;Q9BVA1 TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 198199200.0 49411600.0 20102600.0 128685000.0 False True 47843055.80454238 28129673.013674103 94978538.03275096 1.0 0.5879572811693893 1.9852105271196616 25.511806203690377 -6.82772470653198 1.3380348996248947 0.7794626877833621 2.0210958116086966 0.9012528163125278 0.18420970294070577 0.18363261733494518 0.6437721420348649 0.10811908567735193 0.24884864501383996 1.4868778556287777e-07 6.82772470653198 1.2416331238253344 EVDEQMLNVQNK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EVDEQMLNVQNK 12 0 P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P07437;P68371;Q13885;Q9BVA1 TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 250263000.0 14484300.0 97302300.0 138476400.0 False True 19839537.133489642 93003162.65032251 105771126.33097973 1.0 4.687768773260885 5.331330344014699 24.241875031518543 -9.673452781305798 0.4762069702458714 2.878299227202738e-20 5.338689849263893 0.9986666899750068 0.0696803914284529 0.9754483155714376 0.20785926660327939 1.751459352870763 0.13610048052370688 2.1210319898873301e-10 9.673452781305798 5.338689849263893 EVDEQMLNVQNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVDEQMLNVQNK 12 0 P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P07437;P68371;Q13885;Q9BVA1 TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 50043300.0 43017000.0 7026300.0 0.0 False True 35770541.476218194 6988447.927288639 0.0 1.0 0.1953688045772207 0.0 25.092268621491897 -9.50755915599227 0.44887484810151146 1.2135576391371936 2.372356399925853e-22 0.9977973441921912 0.02031090855829176 0.9297994853499757 0.20974932226740828 0.3686031798080561 0.04460651277775114 3.1077125670780894e-10 9.50755915599227 -1.2135576391371936 EVDEQMLNVQNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVDEQMLNVQNK 12 0 P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P07437;P68371;Q13885;Q9BVA1 TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 29280000.0 3913000.0 14368000.0 10999000.0 False True 5065455.636761466 13568408.169512924 8997294.859270426 1.0 2.678615536782731 1.7762064273102054 22.272260614329127 -9.742352940513546 6.158816198194644 0.9999999779689493 2.227410982049078 0.7115390946190239 0.3684069762504883 1.1184681219889563e-07 2.157627019561601e-08 0.35670852622242616 0.1189028403023638 1.809868658766205e-10 9.742352940513546 1.2274110040801287 EVDEQMLNVQNK(ub)NSSYFVEWIPNNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVDEQMLNVQNKNSSYFVEWIPNNVK 26 1 P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P07437;P68371;Q13885;Q9BVA1 TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 10729070.0 5400500.0 4390600.0 937970.0 True False 7080107.798516389 3735539.5944247507 840917.8620435655 1.0 0.5276105535013915 0.11877190093345426 22.755339895621297 -7.93139726509871 0.41006312375375054 1.053034220371896 3.9678087059592205e-20 0.9973769727905145 0.01844124359014658 0.10333780207388629 0.08529971835455907 0.041436256438295536 0.08099156027094029 1.1711236056981905e-08 7.93139726509871 -1.053034220371896 down EVDEQMLNVQNK(ub)NSSYFVEWIPNNVK ddPTM_RPMI8226_Bortezomib_2h_R1 2 EVDEQMLNVQNKNSSYFVEWIPNNVK 26 1 P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P07437;P68371;Q13885;Q9BVA1 TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 181398300.0 60091000.0 35669000.0 85638300.0 True False 58183444.09715034 49911817.71137775 63207060.13606967 1.0 0.8578353943441153 1.0863409878337775 25.794105361729436 -6.738478113880795 1.6924507180747317 0.9152616850893837 1.0864257120596705 0.5979811609339919 0.05973404426828418 0.3205924529049618 1.8025307415636718 0.027929151710767274 0.06864561772299105 1.8260887718640783e-07 6.738478113880795 0.17116402697028688 EVDEQMLNVQNK(ub)NSSYFVEWIPNNVK ddPTM_RPMI8226_Bortezomib_8h_R1 2 EVDEQMLNVQNKNSSYFVEWIPNNVK 26 1 P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P07437;P68371;Q13885;Q9BVA1 TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 873357000.0 154327000.0 145464000.0 573566000.0 True False 234125341.81497267 119504812.68458049 460200428.69709164 1.0 0.5104309160134581 1.965615619093401 27.802705859854058 -6.815967476537869 1.3892647809163587 0.7350032760082735 1.9947106371682861 0.8748496848452401 0.2138798276463337 0.1987730160913301 0.7549026711892187 0.12101280265910384 0.27925453744300494 1.5276804589483002e-07 6.815967476537869 1.2597073611600127 EVDEQMLNVQNK(ub)NSSYFVEWIPNNVK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 EVDEQMLNVQNKNSSYFVEWIPNNVK 26 1 P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P07437;P68371;Q13885;Q9BVA1 TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 189415300.0 60091000.0 64216600.0 65107700.0 True False 49968328.98266797 63870652.42980282 78721419.04600798 1.0 1.2782227008623206 1.5754262879856022 25.574510637163712 -6.9702867778165345 0.2512499859137404 0.907120023241826 1.955247438748565 0.9999845310039014 0.0009240924129562528 0.07620982524179784 0.008696933001152207 0.006572992650631448 0.02842632029925626 1.0708119821053146e-07 6.9702867778165345 1.048127415506739 EVDEQMLNVQNK(ub)NSSYFVEWIPNNVK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 EVDEQMLNVQNKNSSYFVEWIPNNVK 26 1 P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P07437;P68371;Q13885;Q9BVA1 TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 926883000.0 154327000.0 129591000.0 642965000.0 True False 199779343.73996577 122379146.93035574 525951967.37801695 1.0 0.6125715734137426 2.6326644062991806 27.573832181946507 -6.857019433552774 1.2006772597107864 0.7912351555371788 2.725071576939761 0.9499112275911394 0.19591258283339982 0.1499102177210297 0.412362833687827 0.12740557416102746 0.2964799852995111 1.3898904358261337e-07 6.857019433552774 1.9338364214025823 up EVDFKPFGTLLHTYSVLSPTGGENFTFQIYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVDFKPFGTLLHTYSVLSPTGGENFTFQIYK 31 1 O14929;O14929-2 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 0 607681000.0 218610000.0 166065000.0 223006000.0 False True 331647352.53177494 136429403.27823272 178928766.35299802 1.0 0.41136888998732923 0.539515135541011 28.305074768301424 -9.874101930753447 6.730143280531385 1.0000000138783627 0.47544201276461256 0.9571580065854393 0.05231548567670522 1.085492347133085e-08 1.9066045890165484e-09 0.0506542519484396 0.016884750397878283 1.3362818487313804e-10 9.874101930753447 -0.5245580011137501 EVDGVWVYNRSSYPIFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVDGVWVYNRSSYPIFIK 18 1 K7EKF0;O15105-2;O15105-3;O15105 K7EKF0 SMAD7 Mothers against decapentaplegic homolog 7 0 9888470.0 3237970.0 4753500.0 1897000.0 False True 4245010.026546083 4044296.328997873 1700716.6373089156 1.0 0.9527177329869537 0.4006390153788846 22.01733653069524 -6.923792102253646 0.7960957220313317 1.0105983075395348 0.3033532933632868 0.9951711076856161 0.018907076984724863 0.09599168489328248 0.09442631127642771 0.016626540677018842 0.05176292933133289 1.1918123947706604e-07 6.923792102253646 -0.7072450141762481 down EVDGVWVYNRSSYPIFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVDGVWVYNRSSYPIFIK 18 1 K7EKF0;O15105-2;O15105-3;O15105 K7EKF0 SMAD7 Mothers against decapentaplegic homolog 7 0 17699600.0 5082200.0 5789000.0 6828400.0 False True 4920868.342855628 8100577.88923619 5039837.192391002 1.0 1.646168384284662 1.0241763935237362 22.230481487204504 -10.432285575170956 4.549348538130045 0.9991239328632613 1.3351723889045388 0.27910964116727455 0.25392716691154316 0.0022620083513262444 0.00028227613463571813 0.24648556568491045 0.08195464071633704 3.6958507508074235e-11 10.432285575170956 0.33604845604127753 EVDGVWVYNRSSYPIFIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVDGVWVYNRSSYPIFIK 18 1 K7EKF0;O15105-2;O15105-3;O15105 K7EKF0 SMAD7 Mothers against decapentaplegic homolog 7 0 42007700.0 17892900.0 17724400.0 6390400.0 False True 27144837.44620919 14561342.338630706 5127334.638988179 1.0 0.5364313699607074 0.18888802149390724 24.69417450868842 -8.054745469447793 0.31602922778816356 1.116053996678855 3.5262469452038533e-23 0.9989384926275129 0.010825368313361606 0.09438196170857366 0.06503903850168681 0.06134622871477458 0.08986310981580739 8.815653879385728e-09 8.054745469447793 -1.116053996678855 down EVDGVWVYNRSSYPIFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVDGVWVYNRSSYPIFIK 18 1 K7EKF0;O15105-2;O15105-3;O15105 K7EKF0 SMAD7 Mothers against decapentaplegic homolog 7 0 18281100.0 5082200.0 11250800.0 1948100.0 False True 4226074.479634474 11190189.707291052 2355438.7030033073 1.0 2.647892213262395 0.5573585402609933 22.01088676263878 -6.696527820165504 1.8429737618021795 2.0267311841628284 0.5639140478720973 0.40120103214576797 0.6960476562796392 0.40281290042778833 2.6573618594222985 0.3015649722581557 0.7789671690321343 2.0112783550052353e-07 6.696527820165504 -1.462817136290731 EVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLK(ub)EAALYPHLPPEADPR ddPTM_RPMI8226_Bortezomib_2h_R1 2 EVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPR 49 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 176684200.0 81732200.0 18994300.0 75957700.0 True False 79137656.04894441 26578823.043965943 56062099.687844574 1.0 0.3358555758528871 0.7084124358342347 26.23786099946601 -10.715745314960627 6.958388854139732 1.00502749322818 0.5221340058438799 0.6868779184529206 0.15209570118796994 0.011910041871479878 0.0004865322493636479 0.1478552901475248 0.04908867647756223 1.9242198259820625e-11 10.715745314960627 -0.48289348738430005 EVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLK(ub)EAALYPHLPPEADPR ddPTM_RPMI8226_Bortezomib_8h_R1 2 EVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPR 49 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 521009000.0 115623000.0 239776000.0 165610000.0 True False 175408544.17355773 196986099.42156133 132877110.91055848 1.0 1.123013136843857 0.7575292956030888 27.38614378246079 -6.815918988960021 1.3893492322587084 1.0665908978407386 0.7502225276209552 0.874747461132817 0.05373829723185485 0.1988459860829539 0.7552638966927632 0.03040218273790291 0.07016274541395105 1.5278510290647896e-07 6.815918988960021 -0.31636837021978337 EVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLK(ub)EAALYPHLPPEADPR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 EVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPR 49 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 187521500.0 81732200.0 49411300.0 56378000.0 True False 67963945.65038393 49145111.51952483 68166379.13758042 1.0 0.7231056268029842 1.002978542302971 26.018266274900288 -11.004272965705951 10.109068346177137 1.151280461175757 0.8630420845526494 0.24201905213213937 0.11425763930000676 0.06211394163749441 2.625469763185715e-05 0.017639223794845282 0.0368764945154917 9.90209376166417e-12 11.004272965705951 -0.2882383766231076 EVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLK(ub)EAALYPHLPPEADPR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 EVDPSTGELQSLQMPESEGPSSLDPSQEGPTGLKEAALYPHLPPEADPR 49 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 629349000.0 115623000.0 317614000.0 196112000.0 True False 149676252.7700669 299938501.6948555 160421628.2790475 1.0 2.0039150910306525 1.0717907838425624 27.157270104553238 -6.628563163688668 2.0852228860750994 1.662064717140849 1.0754846507270877 0.112510867445201 0.4307778488128007 0.562743022070378 4.660872307694349 0.1690565394404581 0.4773746481874447 2.3519973945568914e-07 6.628563163688668 -0.5865800664137613 EVDQAIK(ub)STAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVDQAIKSTAEK 12 1 Q9NX01;H3BUL8;H3BN11;H3BQ09 Q9NX01 TXNL4B Thioredoxin-like protein 4B 1 6241150.0 2788890.0 584060.0 2868200.0 True False 3610273.0822406574 551556.5475699977 2346217.0302172415 1.0 0.15277419048524804 0.6498724547343937 21.783676536490304 -10.216239154648143 11.236364559225297 1.0000000009344683 0.40132332273439025 0.6591592932575896 0.20293951657226736 4.872257585254473e-09 2.60583273112389e-10 0.1964953419929438 0.06549844733098129 6.078002093780167e-11 10.216239154648143 -0.5986766782000781 EVDRPGSK(ub)VNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVDRPGSKVNK 11 2 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 1 6460330.0 195730.0 3361200.0 2903400.0 True False 256603.92545201644 2859722.0618549814 2602984.019379388 1.0 11.144498498288694 10.143975836667908 17.96918371496121 -9.957072954164076 7.728893532929001 0.9999999161322483 10.644237167478302 0.9919926682574209 0.40846166617704316 5.8713373942245e-07 7.929997876044204e-08 0.39549130766606655 0.1318304358889847 1.1038931688515935e-10 9.957072954164076 9.644237251346054 EVDRPGSK(ub)VNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVDRPGSKVNK 11 2 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 1 13236900.0 2858200.0 5602000.0 4776700.0 True False 2767468.005499579 7838907.814044076 3525538.9720716523 1.0 2.832519761191967 1.273922215203795 21.40013520753284 -6.606698561005113 2.166298717869727 2.2270608144869333 1.2793873993548739 0.04008967125209628 0.790735743410631 0.6218740677989627 5.5254473917631115 0.30196680555957295 0.8781774655943838 2.47344033692422e-07 6.606698561005113 -0.9476734151320594 EVDRPGSK(ub)VNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVDRPGSKVNK 11 2 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 1 4510630.0 195730.0 2092700.0 2222200.0 True False 268096.67040436435 2000237.5943665272 1697362.1276456036 1.0 7.460881895137349 6.331157060195896 18.032393776484103 -9.414702937014402 10.624400932322818 1.0000000080722111 6.896019477028436 0.9732026361505128 0.46120823255941995 0.0 0.0 0.4465629576134033 0.1488543169863656 3.848549377386101e-10 9.414702937014402 5.896019468956225 EVDRPGSK(ub)VNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVDRPGSKVNK 11 2 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 1 8875500.0 2858200.0 4892300.0 1125000.0 True False 2376719.9397291047 4865944.208854477 1360232.29858771 1.0 2.0473359639542092 0.5723149269083623 21.180540482967118 -6.7159893510907205 1.7736088418831804 1.6399008669955162 0.5750955771310082 0.4935732816845767 0.44095410666987356 0.36317541126301467 2.2304089210290297 0.19757218534656618 0.4983609103808409 1.923138883735475e-07 6.7159893510907205 -1.064805289864508 EVEAK(ub)APILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVEAKAPILK 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 14479400.0 5350300.0 6027800.0 3101300.0 True False 7014295.112378896 5128475.73618037 2780407.2257702355 1.0 0.7311462740040102 0.39639153774173913 22.741866699688064 -6.968166988666837 0.29874111283735233 1.0589331237637853 0.05813413965988198 0.9999643469708808 0.0014742993186793768 0.07690206401394746 0.011147652391852381 0.005588657923046305 0.030062947422475627 1.0760513862754558e-07 6.968166988666837 -1.0007989841039033 down EVEAK(ub)APILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVEAKAPILK 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 17331500.0 5262400.0 5750800.0 6318300.0 True False 5095347.9924921235 8047124.430025825 4663347.685062977 1.0 1.5793081143590342 0.9152167215927766 22.28074924955203 -6.676186390510048 1.9158069053086542 1.367787568565639 0.9178353244825177 0.30663681883505434 0.24573257138956464 0.4470273223321801 3.168880938214661 0.10305749641914685 0.27310554209228444 2.10772336305511e-07 6.676186390510048 -0.4499522440831214 EVEAK(ub)APILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVEAKAPILK 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 27408200.0 10921000.0 7659400.0 8827800.0 True False 16567955.432045726 6292520.226834647 7082981.460637809 1.0 0.37980064906884403 0.42751089533581865 23.981892242024735 -10.015035280004222 7.5198319188676885 1.0000000233736597 0.40365577477648684 0.9952223897685422 0.019477626476102582 7.632349287598709e-09 1.0090145930973797e-09 0.018859131443952796 0.006286376913799518 9.659724048295231e-11 10.015035280004222 -0.5963442485971728 EVEAK(ub)APILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVEAKAPILK 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 13309300.0 5350300.0 4156400.0 3802600.0 True False 7328450.496420928 3972756.504623234 2904504.1970052924 1.0 0.5421004762962444 0.39633264882171143 22.805076761210955 -13.999999999999998 0.16017046178575073 3.2559051985122673 0.2533048629100261 0.9995359198481871 0.0055405838765123375 12.01079050868504 0.12647868120846803 8.417441426479161 0.13038461438343535 1.0000000000000041e-14 13.999999999999998 -3.0026003356022413 EVEAK(ub)APILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVEAKAPILK 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 17301200.0 5262400.0 8445300.0 3593500.0 True False 4375918.763848032 8399803.492639203 4344884.235533281 1.0 1.9195519720417993 0.9929078828950975 22.061154524986307 -6.647858878600023 2.0155358680620377 1.597667998615142 0.996743728224144 0.18574262885391812 0.3926738947025345 0.5137385858987968 3.9975996346444784 0.15811344023367163 0.43507050009325615 2.249785541457492e-07 6.647858878600023 -0.600924270390998 EVEAK(ub)APILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVEAKAPILK 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 24914500.0 10921000.0 7898000.0 6095500.0 True False 14137449.785093792 7458469.357100027 4986181.545111642 1.0 0.5275682298064867 0.35269313920880974 23.753018564117184 -13.999999999999998 0.13806686292247855 3.253170691591365 0.13115161760506377 0.9996107522514407 0.005394209933104542 11.932521204115867 0.1162721404319982 7.2517763935759 0.19780914836129848 1.0000000000000041e-14 13.999999999999998 -3.1220190739863014 EVEEDEYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVEEDEYK 8 0 P14625 P14625 HSP90B1 Endoplasmin 0 17818600.0 6833700.0 1853300.0 9131600.0 False True 6616767.934078255 2593332.354831826 6739760.017872073 1.0 0.3919334002142375 1.018587939764424 22.65769525099078 -10.92344450321827 12.431280611388734 1.0329423994557319 0.7052606699893313 0.2277735185513352 0.25583064448278287 0.1375337788491629 0.0008469720557577869 0.1458551537272314 0.08256898546094404 1.1927666750744005e-11 10.92344450321827 -0.3276817294664005 EVEEEPGIHSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVEEEPGIHSLK 12 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 15433600.0 4126000.0 1002900.0 10304700.0 False True 3995022.388458214 1403363.2000544071 7605589.935626444 1.0 0.3512779312848864 1.9037665364778207 21.929772157490476 -6.793214215537382 1.4835759546308593 0.6389422112251987 1.9217460717373138 0.8115439039307877 0.2763774671730389 0.23059020741304873 1.002551289481083 0.14661097488544167 0.342449824172353 1.6098513809179718e-07 6.793214215537382 1.2828038605121153 EVEPEPTEDK(ub)DLEADEEDTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVEPEPTEDKDLEADEEDTR 20 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 45476400.0 20090000.0 16981000.0 8405400.0 True False 26338184.551836725 14447500.991419567 7535689.8382901205 1.0 0.5485382245304395 0.2861127282124922 24.650652570613612 -8.853130263946978 0.1984065779451513 1.3743666506814485 6.252978047640438e-12 0.9996302774312076 0.005669029192146093 0.35937388061223435 0.06082142553114233 0.22277603443303512 0.13648671549933467 1.4023930023538716e-09 8.853130263946978 -1.3743666506751955 down EVEPEPTEDK(ub)DLEADEEDTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVEPEPTEDKDLEADEEDTR 20 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 30975500.0 14334000.0 9123200.0 7518300.0 True False 13878975.016034901 12766141.336859489 5549031.685834639 1.0 0.9198187418098445 0.3998156693432789 23.72639769078148 -6.934211849364157 0.7113700544836989 1.0068076677141604 0.28063041478300577 0.99730321770331 0.013816231173699652 0.09050908824910268 0.06739361454356224 0.01291898538181478 0.04601043953047466 1.1635583058298922e-07 6.934211849364157 -0.7261772529311546 down EVEPEPTEDK(ub)DLEADEEDTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVEPEPTEDKDLEADEEDTR 20 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 50132400.0 20090000.0 23038000.0 7004400.0 True False 27517815.911836054 22020104.98352178 5350104.9801461855 1.0 0.8002126714587993 0.19442331460052323 24.713862632136504 -7.019557908510749 0.5741452683364118 1.0059087030746696 1.4238021808060083e-13 0.9992109381853613 0.009621331835329787 0.07520145367029217 0.03642535923767572 0.010378589982191698 0.0449130457199253 9.559652188133385e-08 7.019557908510749 -1.0059087030745273 down EVEPEPTEDKDLEADEEDTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVEPEPTEDKDLEADEEDTR 20 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 0 9841010.0 2165300.0 884710.0 6791000.0 False True 2096563.7367252968 1237979.3167017004 5012233.37436695 1.0 0.5904801723964509 2.3906897207884312 20.999595258921683 -6.846899189881584 1.2498699275845697 0.7819021420632726 2.458497046600597 0.9356789248762831 0.1954010065936176 0.16090544716417382 0.48525562581226234 0.12242100713374683 0.2828001020903407 1.4226589819152388e-07 6.846899189881584 1.6765949045373245 up EVEQFTQVAK(ub)AYQDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVEQFTQVAKAYQDR 15 1 O96000-2;O96000;H3BPJ9 O96000-2 NDUFB10 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 1 180667200.0 7515200.0 19372000.0 153780000.0 True False 11401107.834713863 15914915.245873168 123385315.59583174 1.0 1.3959095446335272 10.822221610793875 23.44267068070631 -6.915725287362227 0.8558331172473446 0.7582865921854105 12.202263150995137 0.9929087237620781 0.3822953549485808 0.10075256145923647 0.11913120975263494 0.32213678541866747 0.9288103402439202 1.2141566214423383e-07 6.915725287362227 11.443976558809727 up EVEQLIK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVEQLIKK 8 1 P25789;H0YN18;P25789-2 P25789 PSMA4 Proteasome subunit alpha type-4 1 3736760.0 771560.0 1145500.0 1819700.0 True False 1011522.6317976692 974595.8651240277 1631414.8997949548 1.0 0.9634938799065568 1.6128308438295824 19.948097168426496 -6.893586685854646 1.0009063284602386 0.9680491970436185 1.6727714077051201 0.9830963169822288 0.03872717333088902 0.11628341342931894 0.20522916836160143 0.02933305145861677 0.07413936164039253 1.2776541623535182e-07 6.893586685854646 0.7047222106615016 EVEQLIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVEQLIKK 8 1 P25789;H0YN18;P25789-2 P25789 PSMA4 Proteasome subunit alpha type-4 1 7031200.0 1519500.0 2151800.0 3359900.0 True False 1471264.3042322474 3011024.961488757 2479841.3951605815 1.0 2.0465561169582007 1.685517271116451 20.488625011126285 -10.428458930434774 4.875096509964234 0.9985834939959207 1.8660366940374744 0.8846851405022471 0.14739349160645357 0.002272375848821296 0.0002664058053077456 0.14290995033913953 0.047571044860856664 3.728559428338066e-11 10.428458930434774 0.8674532000415537 EVEQLIK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVEQLIKK 8 1 P25789;H0YN18;P25789-2 P25789 PSMA4 Proteasome subunit alpha type-4 1 14594800.0 3254800.0 7498100.0 3841900.0 True False 4937769.557753178 6160005.472077309 3082546.7810354107 1.0 1.2475279374682446 0.6242791902257291 22.235428077808844 -6.798962055291779 1.460349287702335 1.1367524405258262 0.6159141215777335 0.8290530779528147 0.10593934208648224 0.22224432658483995 0.9358554699472089 0.05707536740390527 0.13280911669894913 1.5886855474512894e-07 6.798962055291779 -0.5208383189480927 EVEQLIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVEQLIKK 8 1 P25789;H0YN18;P25789-2 P25789 PSMA4 Proteasome subunit alpha type-4 1 6601500.0 1519500.0 3612600.0 1469400.0 True False 1263531.5752635836 3593138.2067550444 1776644.746262027 1.0 2.8437264862221467 1.4060944586140662 20.26903028656056 -6.583519600912403 2.2530353065368653 2.2528324778773157 1.4098360075755552 0.0 0.8002518756113842 0.688773074109487 6.581193881342049 0.2975928808587778 0.8937835755396953 2.609037967249705e-07 6.583519600912403 -0.8429964703017605 EVEVEVESMDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVEVEVESMDK 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 15571100.0 2246400.0 6256000.0 7068700.0 False True 2945052.154168543 5322629.185697006 6337298.7317583095 1.0 1.8073123690401023 2.1518460115513562 21.489861752410157 -10.169981124323401 0.19693974402475828 7.689288736064242e-20 2.4618734801344946 0.999424794256893 0.01157739460946489 1.749287495914813 0.09405119649811937 1.1190494055326252 0.2131858126825478 6.761123605245573e-11 10.169981124323401 2.4618734801344946 EVEVEVESMDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVEVEVESMDK 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 9025600.0 3019600.0 1206100.0 4799900.0 False True 2923744.4508454707 1687702.01972841 3542662.1960865716 1.0 0.5772399223332841 1.2116866763311431 21.47938578772477 -6.7270635923730175 1.7336393857823713 0.744761794067152 1.2111323398345692 0.5457344290330937 0.1777631102844389 0.3417697281722921 2.010914226725239 0.08129771778927378 0.20243180217518586 1.8747199786273068e-07 6.7270635923730175 0.4663705457674172 EVEVFK(ub)SSQEIQER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVEVFKSSQEIQER 14 1 A0A087X028;A0A0A0MRN5;Q9NZT2-2;Q9NZT2 A0A087X028 OGFR Opioid growth factor receptor 1 33754500.0 6316800.0 7963700.0 19474000.0 True False 9583047.41993832 6542515.514327896 15624955.3642426 1.0 0.6827176395595886 1.630478769387449 23.19205307690492 -6.81642948723558 1.3872302242270453 0.8283458729507225 1.649630984871483 0.8759818534478453 0.13871704174105812 0.19815945511174912 0.7502499729582672 0.0785977125741113 0.1813519477464992 1.526056147673367e-07 6.81642948723558 0.8212851119207605 EVEVFK(ub)SSQEIQER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVEVFKSSQEIQER 14 1 A0A087X028;A0A0A0MRN5;Q9NZT2-2;Q9NZT2 A0A087X028 OGFR Opioid growth factor receptor 1 13755100.0 3584800.0 6144000.0 4026300.0 True False 2980920.033566895 6110901.052511484 4868180.71449217 1.0 2.0500050265351573 1.63311348834374 21.50732624330341 -10.12356198258377 4.586978706517188 0.999923723622493 1.8415592574600428 0.8445582642463685 0.17019525785400966 118746983.95235392 16.332902547477854 100750.07721352555 0.05826236368000375 7.523813425148976e-11 10.12356198258377 0.8416355338375497 EVEVFK(ub)SSQEIQER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVEVFKSSQEIQER 14 1 A0A087X028;A0A0A0MRN5;Q9NZT2-2;Q9NZT2 A0A087X028 OGFR Opioid growth factor receptor 1 39162000.0 6316800.0 9960200.0 22885000.0 True False 8177222.122743377 9405906.114280539 18720164.819929436 1.0 1.1502568932449335 2.2893061407568815 22.96317939899737 -6.93111228803135 0.7376069498386805 0.983373964527635 2.5299099464752084 0.9967523672943216 0.032804948428217455 0.09206424577120688 0.07488124996724348 0.030087156729083877 0.10244106065098212 1.1718923303931956e-07 6.93111228803135 1.5465359819475735 up EVEVIGGADK(ub)YHSVCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVEVIGGADKYHSVCR 16 1 P04183 P04183 TK1 Thymidine kinase, cytosolic 1 11181900.0 4407700.0 4972500.0 1801700.0 True False 5778537.384227512 4230622.382653187 1615277.3671267633 1.0 0.7321268517186803 0.27953048664799757 22.46227294517369 -7.030791267467941 0.40285264389586417 1.025183941311905 8.890915444300213e-17 0.9998560730254396 0.003567116989125113 0.0732215935672041 0.01801222567262007 0.005892077518868425 0.035394648362606945 9.315554962075128e-08 7.030791267467941 -1.025183941311905 down EVEVIGGADK(ub)YHSVCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVEVIGGADKYHSVCR 16 1 P04183 P04183 TK1 Thymidine kinase, cytosolic 1 46918900.0 15590000.0 5615900.0 25713000.0 True False 23651169.781667676 4613698.767773028 20630814.279591754 1.0 0.19507275159595552 0.8722957244839096 24.49540820492103 -10.697291261048495 9.32990888512716 1.0006989323499238 0.5336842380425398 0.3873196414055814 0.2764751209443623 0.004024604294811999 0.0001305780566181495 0.2680366574227736 0.08923196158818304 2.0077458595064275e-11 10.697291261048495 -0.46701469430738396 EVEVIGGADK(ub)YHSVCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVEVIGGADKYHSVCR 16 1 P04183 P04183 TK1 Thymidine kinase, cytosolic 1 10519900.0 4407700.0 4076700.0 2035500.0 True False 6037345.803613727 3896577.914155888 1554756.8224384047 1.0 0.6454124114977055 0.2575232350460671 22.525483006696582 -7.411219107201399 0.3359992566659174 1.0613054184325905 4.0268327506247024e-14 0.9996334127949383 0.005805521558581233 0.11583436200839047 0.03127121944916744 0.01678698611754357 0.05894414927232662 3.879545884847786e-08 7.411219107201399 -1.0613054184325503 down EVEVIGGADK(ub)YHSVCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVEVIGGADKYHSVCR 16 1 P04183 P04183 TK1 Thymidine kinase, cytosolic 1 10710200.0 5782200.0 2505100.0 2422900.0 True False 4808155.49489247 2491604.5290765846 2929517.1877761465 1.0 0.518203816769929 0.6092808751480827 22.197052122628428 -10.099564021745412 7.366259286371131 1.0000001016010176 0.5637423459590059 0.9683463451278633 0.037182053383358754 6.201454698279458e-08 7.610419634113039e-09 0.036001376429711414 0.01200045612762862 7.951260429769991e-11 10.099564021745412 -0.43625775564201175 EVEVIGGADK(ub)YHSVCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVEVIGGADKYHSVCR 16 1 P04183 P04183 TK1 Thymidine kinase, cytosolic 1 43497200.0 15590000.0 6218200.0 21689000.0 True False 20181562.32484315 5872151.703762898 17741824.547933094 1.0 0.29096616056004654 0.8791105595473755 24.26653452701348 -10.375684985528286 8.247813312876971 1.0000029428915882 0.5850383600539554 0.3989383169526203 0.24010894543247321 1.2993498127710974e-05 9.837127890772288e-07 0.23248613501246812 0.07749482891128284 4.210319121508521e-11 10.375684985528286 -0.4149645828376328 EVFEDAAEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVFEDAAEIR 10 0 P19338;H7BY16 P19338 NCL Nucleolin 0 35735100.0 8478100.0 0.0 27257000.0 False True 11114871.202037182 0.0 24436707.107606266 1.0 0.0 2.1985596291144964 23.40598789487434 -6.783027701427508 1.5239781253906832 0.4360060744395952 2.2176944028467487 0.7780077050257055 0.42346855056761074 0.24588570660974637 1.1281214303928953 0.21881154562764793 0.5150331859213192 1.6480572670147273e-07 6.783027701427508 1.7816883284071534 EVFEDAAEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVFEDAAEIR 10 0 P19338;H7BY16 P19338 NCL Nucleolin 0 43757100.0 8478100.0 17704000.0 17575000.0 False True 11612682.682037696 16921778.740700994 13424146.968486834 1.0 1.4571808430514783 1.1559901648954105 23.46919795639723 -10.359318289154732 5.292755200881025 0.9998753821771982 1.306585503973456 0.5801010799010761 0.12296057946090705 0.00018088602514717728 2.1896031774983644e-05 0.11910418480423134 0.03968535637433635 4.372015679908573e-11 10.359318289154732 0.3067101217962578 EVFK(ub)SDYYNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVFKSDYYNK 10 1 Q86U86-5;Q86U86-4;Q86U86-7;Q86U86-3;Q86U86-9;Q86U86-2;Q86U86-8;Q86U86;E7EVG2;H0Y5B5 Q86U86-5 PBRM1 Protein polybromo-1 1 3098240.0 898180.0 977960.0 1222100.0 True False 869667.7675388746 1368464.527994028 901995.3477858722 1.0 1.5735486344017653 1.037172333451524 19.73010483900047 -10.362875448873316 3.447914488726709 0.9980649505411435 1.3053604838319686 0.3017446141055017 0.21897470883065973 41797663.43880977 78120700.04787363 858196.3873066156 0.08013653600983894 4.336352226143605e-11 10.362875448873316 0.30729553329082504 EVFSK(ub)YGPIADVSIVYDQQSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVFSKYGPIADVSIVYDQQSR 21 1 P62995-3;P62995 P62995-3 TRA2B Transformer-2 protein homolog beta 1 30558800.0 11418000.0 15806000.0 3334800.0 True False 14780826.082428422 14926382.205409355 2727900.617937544 1.0 1.0098476311248916 0.1845567089907442 23.81722356642351 -6.904199720611129 0.9343278989865382 1.0304718836651163 0.0901418970297337 0.9885425700994729 0.04139701702011289 0.10837988288694697 0.16049527863913118 0.03294891474845931 0.08768352029260834 1.2468100072489964e-07 6.904199720611129 -0.9403299866353826 down EVFSMAGVVVR ddPTM_RPMI8226_Bortezomib_1h_R1 2 EVFSMAGVVVR 11 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 45345000.0 13250300.0 14555000.0 17539700.0 False True 17371271.616087727 12383450.734945623 15724860.096682742 1.0 0.7128695589260818 0.9052221647446796 24.05020003064184 -10.243673876455851 6.771870412197598 1.0000014427300656 0.8090458618353807 0.5678509165375718 0.07852762249171191 1.710467785501549e-06 1.9106987762530705e-07 0.07603461792544595 0.025344681177305272 5.705925849433648e-11 10.243673876455851 -0.1909555808946849 EVFSMAGVVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVFSMAGVVVR 11 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 29546600.0 9185800.0 5439800.0 14921000.0 False True 8894201.807052713 7611940.508182239 11012742.479594957 1.0 0.8558317737007387 1.2381934566474908 23.084433708748374 -6.804531411466694 1.437128592286561 0.9209080010699753 1.2440951450754043 0.8451498612913967 0.062042312113666225 0.2143431926285979 0.8734137040563034 0.033953866032107614 0.07876409337696104 1.5684424519387016e-07 6.804531411466694 0.32318714400542903 EVFSMAGVVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EVFSMAGVVVR 11 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 48087900.0 13250300.0 16367700.0 18469900.0 False True 18149293.98589356 15644520.893254185 14107690.019530864 1.0 0.8619906044507188 0.7773134332661089 24.11341009216473 EVFSMAGVVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVFSMAGVVVR 11 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 22834500.0 9185800.0 4543100.0 9105600.0 False True 7638399.699938296 4518625.418565252 11009538.860462442 1.0 0.5915670292301872 1.4413410259941462 22.86483898418265 -6.775959343851295 1.551231515937444 0.7675326388541669 1.447289245214872 0.7530153078908051 0.17245323819250394 0.25687393532612296 1.220526651824135 0.08758176400713324 0.2073978760652067 1.6750996818735952e-07 6.775959343851295 0.6797566063607051 EVGEAFTILSDPKKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVGEAFTILSDPKKK 15 2 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 25798100.0 6024000.0 11511000.0 8263100.0 True False 7798186.750792514 10870402.731017772 6759300.586565818 1.0 1.3939654279134872 0.8667784964086535 22.894707274100263 -6.706676550539606 1.8069468220236682 1.24302486038013 0.868131423475162 0.4492633357027459 0.16610494761690334 0.3818426676303388 2.4281492246088727 0.07320980321529079 0.18674802818568467 1.9648230731402746e-07 6.706676550539606 -0.3748934369049679 EVGSIIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVGSIIGK 8 0 Q15365;F8VTZ0;H3BSP4;C9K0A2;F8WC71;C9IZV9;C9J7A9;C9JSA6;C9J5V4;C9JTY5;C9JZY3;C9J0A4;P57723-2;P57723;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP4;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 4;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 0 16761400.0 2122500.0 7896400.0 6742500.0 False True 2782618.05431924 6718287.899926116 6044850.778626974 1.0 2.4143765938332225 2.17236094233056 21.40801146543336 -10.289439028483912 5.213155484748611 0.9997444607925814 2.293368768082067 0.9744114422925357 0.09880247599207309 0.0002935008995106361 4.000483142445912e-05 0.09568306964681429 0.0318883620066915 5.1352426719478447e-11 10.289439028483912 1.2936243072894855 EVGSIIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVGSIIGK 8 0 Q15365;F8VTZ0;H3BSP4;C9K0A2;F8WC71;C9IZV9;C9J7A9;C9JSA6;C9J5V4;C9JTY5;C9JZY3;C9J0A4;P57723-2;P57723;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP4;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 4;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 0 15185500.0 3987600.0 1609100.0 9588800.0 False True 3861015.8207018874 2251622.021345647 7077205.622166076 1.0 0.5831682971286889 1.832990578339439 21.880549035129818 -6.816787058858833 1.385716203075187 0.7745750303076855 1.8584410041921202 0.8768355083119115 0.18234583121470693 0.19768862025314585 0.7467502103026914 0.10342886184290272 0.2386153896101125 1.524800203099479e-07 6.816787058858833 1.0838659738844347 EVGSIIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVGSIIGK 8 0 Q15365;F8VTZ0;H3BSP4;C9K0A2;F8WC71;C9IZV9;C9J7A9;C9JSA6;C9J5V4;C9JTY5;C9JZY3;C9J0A4;P57723-2;P57723;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP4;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 4;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 0 17443800.0 2122500.0 8018500.0 7302800.0 False True 2907245.60840578 7664216.15636642 5578029.04588709 1.0 2.636246533215739 1.9186645358614416 21.471221526956253 -10.647888269506796 6.121876251978873 0.9910718544170563 2.2774555345385457 0.8086340117571742 0.2929516236875362 0.03538525044998014 0.0020352493907708786 0.2811643233851563 0.09454972998218739 2.249633292229226e-11 10.647888269506796 1.2863836801214894 EVGSIIGK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVGSIIGKK 9 1 Q15365;F8VTZ0;H3BSP4;C9K0A2;F8WC71;C9IZV9;C9J7A9;C9JSA6;C9J5V4;C9JTY5;C9JZY3;C9J0A4;P57723-2;P57723;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP4;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 4;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 1 11243700.0 2917600.0 4472900.0 3853200.0 True False 3825001.85407859 3805560.7552276426 3454507.826504331 1.0 0.994917362241219 0.9031388632716081 21.86702901644171 -6.918319770984814 0.837093679996564 1.0021502641328 0.8888959920493841 0.9937012886233242 0.0035325993148942482 0.09917061173631729 0.11081147563754079 0.0030169175123959066 0.008896918183421048 1.206924849217659e-07 6.918319770984814 -0.11325427208341587 EVGSIIGK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVGSIIGKK 9 1 Q15365;F8VTZ0;H3BSP4;C9K0A2;F8WC71;C9IZV9;C9J7A9;C9JSA6;C9J5V4;C9JTY5;C9JZY3;C9J0A4;P57723-2;P57723;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP4;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 4;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 1 20351700.0 4347500.0 6105900.0 9898300.0 True False 4209490.992201182 8544017.711847851 7305638.287365101 1.0 2.0297032889907918 1.7355158381144118 22.00521436379794 -10.4394058260411 7.065187482075851 0.9999033802995295 1.882609563552602 0.9230845190074038 0.12010152389620381 0.00018280439049009835 1.4504510301116127e-05 0.11630024038681398 0.03876260015867741 3.63575134923214e-11 10.4394058260411 0.8827061832530724 EVGSIIGK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVGSIIGKK 9 1 Q15365;F8VTZ0;H3BSP4;C9K0A2;F8WC71;C9IZV9;C9J7A9;C9JSA6;C9J5V4;C9JTY5;C9JZY3;C9J0A4;P57723-2;P57723;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP4;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 4;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 1 35249500.0 6647300.0 5240200.0 23362000.0 True False 10084440.082724791 4305045.368130529 18744490.460071627 1.0 0.4268997914425921 1.8587537142673876 23.26562764778549 -6.798088065805328 1.4637769881977216 0.6830254284223274 1.877583174052814 0.8264953386156749 0.24509843084014366 0.22349794916241753 0.9456176032758468 0.13174102207368912 0.3067351819721563 1.5918858932739708e-07 6.798088065805328 1.1945577456304866 EVGSIIGK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVGSIIGKK 9 1 Q15365;F8VTZ0;H3BSP4;C9K0A2;F8WC71;C9IZV9;C9J7A9;C9JSA6;C9J5V4;C9JTY5;C9JZY3;C9J0A4;P57723-2;P57723;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP4;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 4;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 1 9981800.0 2917600.0 2666600.0 4397600.0 True False 3996315.565175357 2548780.7947330163 3358977.45141495 1.0 0.6377826658494063 0.8405185718279381 21.9302390779646 -10.137307077652002 5.213803210992841 1.0000082885522985 0.739150618838453 0.6882091179738418 0.08276658703214336 7.974552853715402e-06 1.3193384962747954e-06 0.0801409484872187 0.026712801099716316 7.289419132683537e-11 10.137307077652002 -0.2608576697138455 EVGSIIGK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVGSIIGKK 9 1 Q15365;F8VTZ0;H3BSP4;C9K0A2;F8WC71;C9IZV9;C9J7A9;C9JSA6;C9J5V4;C9JTY5;C9JZY3;C9J0A4;P57723-2;P57723;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP4;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 4;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 1 19462700.0 4347500.0 9777400.0 5337800.0 True False 3615138.876905844 9724727.205538044 6453909.300801321 1.0 2.6900010031872763 1.7852451926619062 21.785619639232216 -9.733041548160301 6.110804598710506 0.9999999776103397 2.2376230979282314 0.7138686126611588 0.3693650129472079 1.1224494834628946e-07 2.3546528368209157e-08 0.35763614127750026 0.11921204531611448 1.8490917112873991e-10 9.733041548160301 1.2376231203178918 EVHK(ub)QVVESAYEVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVHKQVVESAYEVIK 15 1 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 1 13298700.0 2733300.0 4505000.0 6060400.0 True False 3583382.7693148563 3832871.560352458 5433327.94346175 1.0 1.0696238183578988 1.516256647207299 21.77289072671537 -6.93443630462929 0.7094293336564643 0.9941963004094888 1.6192470732978905 0.9973406402290634 0.011795278477682575 0.09039867074264227 0.06686830521299722 0.01104531148398453 0.03947329753448108 1.1629571024495407e-07 6.93443630462929 0.6250507728884017 EVHK(ub)QVVESAYEVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVHKQVVESAYEVIK 15 1 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 1 20172100.0 3354100.0 5809000.0 11009000.0 True False 3247625.931441513 8128563.9935348015 8125412.637079343 1.0 2.5029249566087812 2.5019545996397263 21.630954038690525 -10.024792758233225 5.537542548861067 0.999994022143603 2.5024397781253214 0.9999996870879523 0.0003961465775177608 2.9236190555266763e-08 5.150490399513691e-09 0.0003835687964814707 0.00012785575756934882 9.445114819015537e-11 10.024792758233225 1.5024457559817184 EVHK(ub)QVVESAYEVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVHKQVVESAYEVIK 15 1 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 1 83727800.0 7529800.0 24148000.0 52050000.0 True False 11423257.102116816 19838600.730814863 41762294.68567457 1.0 1.7366851287220544 3.655900791897234 23.4454707277929 -6.954572747270016 0.5061656469300303 0.9635344925609571 4.512701170614951 0.9995129656084449 0.024706499990959026 0.08169997132059703 0.028753669524207184 0.02864909621458379 0.15836066677760968 1.1102665425836218e-07 6.954572747270016 3.5491666780539943 EVHK(ub)QVVESAYEVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVHKQVVESAYEVIK 15 1 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 1 13970300.0 2733300.0 4737700.0 6499300.0 True False 3743874.874655134 4528372.748521194 4964299.197285147 1.0 1.2095416914643344 1.3259789291816095 21.836100788238262 -12.911171997046978 0.07725020774957869 2.651307569079579e-14 1.7121314565609738 0.999918305684073 0.0012190759420218904 8.430766652549623 0.06750752966715788 1.650416328156611 0.3193145179856802 1.2269532150277152e-13 12.911171997046978 1.7121314565609473 EVHK(ub)QVVESAYEVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVHKQVVESAYEVIK 15 1 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 1 18715500.0 3354100.0 8184300.0 7177100.0 True False 2789082.7618240104 8140209.551443639 8677798.42683899 1.0 2.9185973477961933 3.1113449000573454 21.4113593141248 -10.331594437075951 0.4833985278939844 1.0196035025481757e-21 3.10808259002897 0.9994547290610766 0.022256346753356443 1.687482143592699 0.22664815016653583 2.2465827265577207 0.040357404560583524 4.660210809773723e-11 10.331594437075951 3.10808259002897 EVHK(ub)QVVESAYEVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVHKQVVESAYEVIK 15 1 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 1 59086800.0 7529800.0 10820000.0 40737000.0 True False 9747474.534548035 10217857.488455588 33323283.996917836 1.0 1.0482569051337731 3.418658225657314 23.21659704988535 -6.911300346652684 0.8868248880686289 0.9295912247103896 3.733677112325573 0.9914032620779384 0.10467596223656013 0.10356466265665282 0.1341465837156846 0.0862543820147372 0.24030443561254344 1.2265906598954726e-07 6.911300346652684 2.8040858876151833 up EVHK(ub)SGYLSSER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVHKSGYLSSER 12 1 P15311;E7EQR4 P15311 EZR Ezrin 1 6349300.0 2175300.0 2121600.0 2052400.0 True False 2106246.2921990217 2968765.9439978376 1514814.8693197947 1.0 1.4095056000779018 0.7192012040236072 21.006242715924525 -6.74603935104535 1.6650273805550542 1.2419420397839909 0.7182757165411922 0.6315426788587271 0.17205226624973066 0.3070009939714363 1.6733478479269501 0.08168215324086302 0.19909312468934595 1.7945710149464425e-07 6.74603935104535 -0.5236663232427987 EVIASK(ub)APLETPTQLLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVIASKAPLETPTQLLLR 18 1 X6R3U4;Q7Z736-4;Q7Z736-3;Q7Z736-2;Q7Z736 X6R3U4 PLEKHH3 Pleckstrin homology domain-containing family H member 3 1 15856300.0 1451200.0 3528100.0 10877000.0 True False 1405132.4503467176 4936888.728798445 8027987.396994458 1.0 3.513468589797541 5.713331433640683 20.42227469724515 -7.442189941087536 0.2402594927596291 3.220420919822075e-21 8.251395240428698 0.999903330657564 0.018932890327324307 0.12946223988024097 0.022139305621139412 0.18395674127058587 0.46078458305436154 3.612518326025688e-08 7.442189941087536 8.251395240428698 EVIASK(ub)APLETPTQLLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVIASKAPLETPTQLLLR 18 1 X6R3U4;Q7Z736-4;Q7Z736-3;Q7Z736-2;Q7Z736 X6R3U4 PLEKHH3 Pleckstrin homology domain-containing family H member 3 1 73878900.0 3060600.0 9889300.0 60929000.0 True False 4643153.959831431 8124477.149546438 48886356.44387058 1.0 1.749775523239681 10.528695982686173 22.14667368856662 -6.923752400218745 0.7964117880576373 0.8312176244486144 12.07417487501163 0.9951611389834739 0.3009241346063312 0.0960140769053851 0.09454304141312586 0.2645689248988703 0.8233070293718807 1.1919213520384698e-07 6.923752400218745 11.242957250563016 up EVIASK(ub)APLETPTQLLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVIASKAPLETPTQLLLR 18 1 X6R3U4;Q7Z736-4;Q7Z736-3;Q7Z736-2;Q7Z736 X6R3U4 PLEKHH3 Pleckstrin homology domain-containing family H member 3 1 14829400.0 1451200.0 3524700.0 9853500.0 True False 1206737.0990605543 3505711.7415018254 11913821.292563556 1.0 2.9051164037560664 9.872756296162995 20.202679972679427 -6.946934209977834 0.5915453728696975 0.9198265007799256 12.209579995569221 0.9989382036093855 0.12427238376637349 0.0847406800708781 0.04124095233717203 0.12863340402944343 0.5839867164026488 1.1299670771710957e-07 6.946934209977834 11.289753494789295 EVIASK(ub)APLETPTQLLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVIASKAPLETPTQLLLR 18 1 X6R3U4;Q7Z736-4;Q7Z736-3;Q7Z736-2;Q7Z736 X6R3U4 PLEKHH3 Pleckstrin homology domain-containing family H member 3 1 69479500.0 3060600.0 6362900.0 60056000.0 True False 3962007.03344547 6008799.021561372 49126424.226597436 1.0 1.5166048345794974 12.399378348371014 21.917800010659068 -6.916799066385139 0.8481305638779382 0.7310779588842184 14.031302660639602 0.9932445442493851 0.4320142690634842 0.10009188283434503 0.11564488762539689 0.3660480253812878 1.0650656968143184 1.211158366640577e-07 6.916799066385139 13.300224701755383 up EVIAVSCGPAQCQETIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVIAVSCGPAQCQETIR 17 0 P38117-2;P38117 P38117-2 ETFB Electron transfer flavoprotein subunit beta 0 5565190.0 862790.0 2613900.0 2088500.0 False True 1131126.0452702467 2223916.308902396 1872402.054306624 1.0 1.9661083026083637 1.655343418300719 20.109328272086156 -10.310781682668358 5.8817496653693295 0.999928382141272 1.8107258604544987 0.9007395332142346 0.12686923275480472 0.00011917002447540625 1.3964020332971865e-05 0.1228513412393537 0.04094686880045468 4.8889806381794075e-11 10.310781682668358 0.8107974783132267 EVIAVSCGPAQCQETIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVIAVSCGPAQCQETIR 17 0 P38117-2;P38117 P38117-2 ETFB Electron transfer flavoprotein subunit beta 0 6605390.0 862790.0 2766000.0 2976600.0 False True 1181786.7790230503 2643788.9740611687 2273588.385001305 1.0 2.2371116524477572 1.9238566764817053 20.172538333609047 -10.063780988071445 4.862270490887859 0.9999696982232433 2.080484164289565 0.9406978344309895 0.12788580845816722 4.2009233362656304e-05 8.088691261652482e-06 0.12382835944265491 0.041274967192095245 8.634138520785329e-11 10.063780988071445 1.0805144660663215 EVIK(ub)PYDWTYTTDYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVIKPYDWTYTTDYK 15 1 O75663;O75663-2 O75663 TIPRL TIP41-like protein 1 30643000.0 7496700.0 7367300.0 15779000.0 True False 9704625.9320495 6957303.278622819 12907383.906212203 1.0 0.716905868122783 1.3300238460078717 23.21024117418709 -6.781184696470781 1.5315275070191934 0.8399498409259395 1.3350383194242503 0.7714626059168797 0.1197762522978229 0.24874280094659632 1.1525318369478574 0.061596181683594764 0.14518127250014137 1.6550659484238317e-07 6.781184696470781 0.49508847849831084 EVIKSQEVFKDNCCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVIKSQEVFKDNCCK 15 2 O00463-3;O00463;O00463-2 O00463-3 TRAF5 TNF receptor-associated factor 5 0 9588800.0 3526800.0 4233100.0 1828900.0 False True 4623668.953579783 3601537.980494559 1639662.9720475886 1.0 0.7789350874063204 0.35462378221912105 22.140606676478086 -6.960841465247323 0.42340947345257307 1.018081025601434 0.09938194140042239 0.9998001413130838 0.003785829456871295 0.07940190699071203 0.020030869068421903 0.005501810372910286 0.03528827702426978 1.094355776735473e-07 6.960841465247323 -0.9186990842010117 down EVIKSQEVFKDNCCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVIKSQEVFKDNCCK 15 2 O00463-3;O00463;O00463-2 O00463-3 TRAF5 TNF receptor-associated factor 5 0 20273600.0 8932000.0 6939700.0 4401900.0 False True 13550497.016668094 5701256.314876414 3531862.5355786877 1.0 0.4207414907263885 0.2606445011746979 23.691842433158357 -13.999999999999924 0.18043138549225435 4.009491539462184 0.13403592285681604 0.9994976242603358 0.007118562975813807 12.210346716539538 0.1346595749874896 12.883932738998274 0.11909734099153531 1.0000000000001759e-14 13.999999999999924 -3.8754556166053677 EVIKSQEVFKDNCCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVIKSQEVFKDNCCK 15 2 O00463-3;O00463;O00463-2 O00463-3 TRAF5 TNF receptor-associated factor 5 0 8573000.0 3526800.0 3820900.0 1225300.0 False True 4830753.268186336 3652080.0039733616 935909.3758456297 1.0 0.7560063205928343 0.19373984219173518 22.203816738000977 -7.107923551961503 0.5263420994379333 1.007913700348355 3.0890026000027127e-24 0.9993090738830503 0.008873836034618434 0.07723289430273102 0.033745358315040996 0.009872958448284007 0.0435915265341086 7.799673946293005e-08 7.107923551961503 -1.007913700348355 down EVIKSQEVFKDNCCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVIKSQEVFKDNCCK 15 2 O00463-3;O00463;O00463-2 O00463-3 TRAF5 TNF receptor-associated factor 5 0 4531910.0 2240200.0 1456900.0 834810.0 False True 1862825.5576870576 1449051.3905279925 1009364.9112746723 1.0 0.7778781993560255 0.5418461793749122 20.82906115029026 -6.970355230961626 0.24956557521282183 1.0753069612590354 0.23750826509283 0.9999850185839573 0.0007240441125558509 0.07618767983595803 0.008617190646608128 0.005279924229788974 0.022637502804342402 1.0706432148873183e-07 6.970355230961626 -0.8377986961662054 EVIKSQEVFKDNCCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVIKSQEVFKDNCCK 15 2 O00463-3;O00463;O00463-2 O00463-3 TRAF5 TNF receptor-associated factor 5 0 18993100.0 8932000.0 5025300.0 5035800.0 False True 11562650.076042268 4745637.637406276 4119336.0716714254 1.0 0.4104281982241428 0.3562622793719808 23.462968755250806 -13.999999999999998 0.33780302750472657 7.728360910445218 0.347524193120167 0.9997308001193006 0.004783280912768023 19.50398512787014 0.18630111519557419 93.60594962949098 0.016867634736733327 1.0000000000000041e-14 13.999999999999998 -7.380836717325051 EVILVLSAPFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVILVLSAPFLR 12 0 O60343-2;O60343-3;O60343 O60343-2 TBC1D4 TBC1 domain family member 4 0 33353700.0 8744700.0 13021000.0 11588000.0 False True 13266349.22320394 10697300.81646265 9297626.720799161 1.0 0.8063485014967183 0.7008429044319777 23.66126807318478 -13.999999998839188 0.07384780041753214 2.087922539980822 0.34650413515364203 0.9999107758252886 0.0011701849107078664 12.320620089894375 0.07462304992167512 2.258237434921751 0.3244761034975131 1.0000000026728682e-14 13.999999998839188 -1.7414184048271801 EVILVLSAPFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVILVLSAPFLR 12 0 O60343-2;O60343-3;O60343 O60343-2 TBC1D4 TBC1 domain family member 4 0 22856100.0 8744700.0 6375600.0 7735800.0 False True 11320186.533807311 6020792.255397171 6327963.7760109175 1.0 0.531863343189293 0.558998189394909 23.43239439527723 -10.689952514540835 6.697898808124891 1.0038100735003515 0.545430766292104 0.9973346335044757 0.011077754575442578 0.0006333619869185774 2.931844852225959e-05 0.010778636926837967 0.00357532991533851 2.041961199093453e-11 10.689952514540835 -0.4583793072082475 EVIPMAAVK(ub)QALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVIPMAAVKQALR 13 1 Q5QP56;Q9H1R6;Q5TE64;Q07817-2;Q07817-3;Q07817 Q5QP56 BCL2L1 Bcl-2-like protein 1 1 42783900.0 10239400.0 14761800.0 17782700.0 True False 13423952.558490664 12559396.981045729 15942716.787703326 1.0 0.9355960493991687 1.1876320866181505 23.678306186491124 -6.8389178469082585 1.2872858874244808 0.9657301826916799 1.1957518068163508 0.9225904622352468 0.02974627967481807 0.17007285157908383 0.5479025561978751 0.01812186941604429 0.0417408622527967 1.4490459356479148e-07 6.8389178469082585 0.23002162412467098 EVIPMAAVK(ub)QALR ddPTM_RPMI8226_Bortezomib_2h_R1 2 EVIPMAAVKQALR 13 1 Q5QP56;Q9H1R6;Q5TE64;Q07817-2;Q07817-3;Q07817 Q5QP56 BCL2L1 Bcl-2-like protein 1 1 75235350.0 17347150.0 18492500.0 39395700.0 True False 16796474.21859985 25876651.68711352 29076784.324333426 1.0 1.540600208730627 1.7311242791737076 24.001655090002718 -11.271901639398243 0.19319392434780167 4.9178341662896745e-19 1.8878022213557393 0.9994112265198642 0.007514169032905021 3.623837883871849 0.11236507330696174 1.6834899190805612 0.12548634667137443 5.346854431983382e-12 11.271901639398243 1.8878022213557393 EVIPMAAVK(ub)QALR ddPTM_RPMI8226_Bortezomib_8h_R1 2 EVIPMAAVKQALR 13 1 Q5QP56;Q9H1R6;Q5TE64;Q07817-2;Q07817-3;Q07817 Q5QP56 BCL2L1 Bcl-2-like protein 1 1 170320300.0 30451500.0 79596800.0 60272000.0 True False 46197151.8028514 65392129.14736299 48359212.78184392 1.0 1.4155013154583012 1.0468007419206107 25.461300571987763 -10.468888515206272 6.613735825573631 0.9999289989507337 1.2311510286894558 0.34385876672803406 0.15052137883980796 0.00015763193547097966 1.2658519011271225e-05 0.1457862939896546 0.0485805661245628 3.3971246668390326e-11 10.468888515206272 0.23122202973872208 EVIPMAAVK(ub)QALR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EVIPMAAVKQALR 13 1 Q5QP56;Q9H1R6;Q5TE64;Q07817-2;Q07817-3;Q07817 Q5QP56 BCL2L1 Bcl-2-like protein 1 1 41431400.0 11737500.0 13277300.0 16416600.0 True False 16077170.944010735 12690664.983840328 12539337.19048997 1.0 0.7893593361690298 0.7799467477305936 23.93851022594435 EVIPMAAVK(ub)QALR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 EVIPMAAVKQALR 13 1 Q5QP56;Q9H1R6;Q5TE64;Q07817-2;Q07817-3;Q07817 Q5QP56 BCL2L1 Bcl-2-like protein 1 1 56101550.0 17347150.0 23027200.0 15727200.0 True False 14424923.834046531 22903147.903058685 19015684.805643223 1.0 1.5877482728193937 1.3182520077340938 23.782060365436994 -9.99596109685333 4.375640473141573 0.9999819903768712 1.4530001401697574 0.7902375454388532 0.11002138984914245 76394689.91406235 199248208.75662085 22458.413677787852 0.040263708757374075 1.0093432967848432e-10 9.99596109685333 0.45301814979288624 EVIPMAAVK(ub)QALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVIPMAAVKQALR 13 1 Q5QP56;Q9H1R6;Q5TE64;Q07817-2;Q07817-3;Q07817 Q5QP56 BCL2L1 Bcl-2-like protein 1 1 113821000.0 23536000.0 63580100.0 26704900.0 True False 30467815.963919736 60041811.54360034 21844882.215413302 1.0 1.9706634572921933 0.7169822162928321 24.860782750683164 -6.70000755803685 1.8311091819124412 1.6027398404576219 0.7207408798919038 0.41754422708758754 0.40972784705060783 0.39547852622844726 2.578051690701573 0.17852162296746443 0.45906081244984465 1.9952275916751014e-07 6.70000755803685 -0.881998960565718 EVITSDELMAHLGNCLLSIK(ub)PQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVITSDELMAHLGNCLLSIKPQEK 24 1 Q8N5J2-2;Q8N5J2-4;Q8N5J2;Q8N5J2-3 Q8N5J2-2 FAM63A Protein FAM63A 1 15814700.0 5360800.0 9198700.0 1255200.0 True False 7028060.714061041 7826289.816251757 1125323.9447285973 1.0 1.1135774340414701 0.16011869995334013 22.74469522388851 -6.877161479620416 1.0954617499994377 1.068074373205035 0.09610866147623819 0.9713248715370272 0.07200728717781757 0.13017635114202095 0.2877070361022016 0.05075614542145223 0.12190810008903294 1.3269009969152336e-07 6.877161479620416 -0.9719657117287969 down EVITSDELMAHLGNCLLSIK(ub)PQEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVITSDELMAHLGNCLLSIKPQEK 24 1 Q8N5J2-2;Q8N5J2-4;Q8N5J2;Q8N5J2-3 Q8N5J2-2 FAM63A Protein FAM63A 1 178396000.0 54405000.0 82653000.0 41338000.0 True False 82536362.53827 67902926.37916352 33167526.18091096 1.0 0.8227031612603314 0.40185350021370314 26.29852652291468 -6.956563318083013 0.4814372085391968 1.0099662116368382 0.1970016479280749 0.9996207136734284 0.004885353469840382 0.08095250883342842 0.025847597847224305 0.005951264964887377 0.03471486386262231 1.1051893262554621e-07 6.956563318083013 -0.8129645637087632 down EVITSDELMAHLGNCLLSIK(ub)PQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVITSDELMAHLGNCLLSIKPQEK 24 1 Q8N5J2-2;Q8N5J2-4;Q8N5J2;Q8N5J2-3 Q8N5J2-2 FAM63A Protein FAM63A 1 31429200.0 16363000.0 4655200.0 10411000.0 True False 13606559.503809176 4630121.513615147 12587891.964974789 1.0 0.34028598576436153 0.925134084148957 23.697798983494632 -10.539130282403468 9.062348001390214 1.0000244594844423 0.632710034956681 0.34463217134173196 0.23876323634655228 0.00011800120527500732 6.001154222628156e-06 0.2311968449743659 0.07706050317139854 2.8898128480006913e-11 10.539130282403468 -0.3673144245277613 EVITSDELMAHLGNCLLSIK(ub)PQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVITSDELMAHLGNCLLSIKPQEK 24 1 Q8N5J2-2;Q8N5J2-4;Q8N5J2;Q8N5J2-3 Q8N5J2-2 FAM63A Protein FAM63A 1 161363000.0 54405000.0 72879000.0 34079000.0 True False 70428344.98287947 68823219.5842103 27876971.680068836 1.0 0.9772090995598525 0.3958203431707147 26.06965284500713 -6.915168255409201 0.8597943039479529 1.0151943736869886 0.31174697786250466 0.9927301344881517 0.02383933563825216 0.10109898081378396 0.12096213143564623 0.020030735207342675 0.05748980476081186 1.2157149142113595e-07 6.915168255409201 -0.703447395824484 down EVK(ub)EWHGCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVKEWHGCR 9 1 Q92499;F1T0B3;A0A087X2G1;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 1 1618950.0 1095500.0 0.0 523450.0 True False 1060723.952146382 0.0 386342.74183660414 1.0 0.0 0.36422552828644716 20.016617820594213 -10.603653737087301 6.439749961730013 1.0022925699687326 0.1821127641432371 0.8705222762662898 0.14869444926623945 0.004902307501896019 0.00030172108453969677 0.14420912294815058 0.047990927140135725 2.4908424750542532e-11 10.603653737087301 -0.8201798058254955 EVK(ub)EWHGCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVKEWHGCR 9 1 Q92499;F1T0B3;A0A087X2G1;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 1 3441500.0 756270.0 752830.0 1932400.0 True False 1147316.8807429003 618481.6046123634 1550460.2929989903 1.0 0.5390678155209306 1.3513793085612495 20.129832477799134 -6.752777777222539 1.639625941703771 0.7298758294261912 1.3533365958596122 0.660824221402635 0.1937188833944372 0.29521880075605755 1.5623448663284565 0.09330093250141813 0.2258473498102511 1.7669417102584074e-07 6.752777777222539 0.623460766433421 EVK(ub)QNIHLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVKQNIHLIR 10 1 Q9UHA3 Q9UHA3 RSL24D1 Probable ribosome biogenesis protein RLP24 1 6340560.0 737760.0 1084800.0 4518000.0 True False 714340.2126294066 1517966.2971572673 3334600.2629052987 1.0 2.1249906841584667 4.668084204067145 19.446251812241194 -6.957581182835007 0.4682788577055606 0.931694152129151 5.9653336103314265 0.9996697043487337 0.027885137676991793 0.08057674751236715 0.024411581522738666 0.03504976905696952 0.20992249066978172 1.1026021047475485e-07 6.957581182835007 5.033639458202275 EVK(ub)QNIHLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVKQNIHLIR 10 1 Q9UHA3 Q9UHA3 RSL24D1 Probable ribosome biogenesis protein RLP24 1 3511260.0 737760.0 1521200.0 1252300.0 True False 613480.1283096161 1513004.9936654407 1514150.140019011 1.0 2.466265692801455 2.4681323324866318 19.22665708767547 EVK(ub)QNIHLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVKQNIHLIR 10 1 Q9UHA3 Q9UHA3 RSL24D1 Probable ribosome biogenesis protein RLP24 1 7115200.0 1245800.0 2534700.0 3334700.0 True False 1612712.6583893267 2393641.71681963 2727818.8169114566 1.0 1.4842332292537748 1.6914475140511553 20.62105798162739 -11.17433458300752 0.15848791861694556 2.814125353931544e-17 1.9399980750442787 0.9995902039465189 0.005865231879297111 3.5327975322005174 0.09445237136498118 1.4440949818477589 0.1812213657306933 6.693687251432781e-12 11.17433458300752 1.9399980750442787 EVLAGRPLFPHVLCHNCAVEFNFGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVLAGRPLFPHVLCHNCAVEFNFGQK 26 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 287927000.0 81557000.0 46731000.0 159639000.0 False True 123727931.61536045 38391487.939030506 128086281.67774065 1.0 0.31028958003096785 1.0352252721392712 26.882595984992122 -10.13905699817173 13.711377155262433 0.9999960696292162 0.6727574260851195 0.21364704636980947 0.29595375700815163 0.0 0.0 0.28655599303109114 0.09551866434369702 7.260106672621536e-11 10.13905699817173 -0.3272386435440967 EVLAGRPLFPHVLCHNCAVEFNFGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVLAGRPLFPHVLCHNCAVEFNFGQK 26 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 240506000.0 81557000.0 75041000.0 83908000.0 False True 105577144.22881539 70864902.3836595 68637604.96878462 1.0 0.6712144271498318 0.6501180295237727 26.65372230708457 -13.999999999999998 0.3904265243743888 6.212603409304503 0.6485934207727331 0.9998237825062829 0.002126533853189346 25.408520477221682 0.20486375958121705 111.78925726148175 0.005545748377086834 1.0000000000000041e-14 13.999999999999998 -5.56400998853177 EVLEK(ub)QPVLSQTEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVLEKQPVLSQTEAR 15 1 P28070 P28070 PSMB4 Proteasome subunit beta type-4 1 71714200.0 5358200.0 13889000.0 52467000.0 True False 7024652.088882619 11816815.338897962 47038218.13900204 1.0 1.6821922551295507 6.696163389137213 22.74399534382883 -6.9317087211513115 0.7326296667211402 0.9283790833548349 7.771778766218887 0.9968635373512871 0.14223477509276725 0.09176035094518038 0.07340431346318192 0.1309252448600601 0.4494914180876699 1.1702840307333831e-07 6.9317087211513115 6.843399682864052 up EVLEK(ub)QPVLSQTEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVLEKQPVLSQTEAR 15 1 P28070 P28070 PSMB4 Proteasome subunit beta type-4 1 177639000.0 14387000.0 16252000.0 147000000.0 True False 13930292.560045654 22741508.353060387 108496290.09452839 1.0 1.632521948482743 7.788514823135403 23.73172222154014 -6.926642254663016 0.7738574230609699 0.8938165893194386 8.950629413042758 0.9958361811926114 0.19758096438295536 0.09441909447344589 0.08649905241127999 0.17653266174598914 0.5676416908321394 1.1840164747722438e-07 6.926642254663016 8.05681282372332 up EVLEK(ub)QPVLSQTEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVLEKQPVLSQTEAR 15 1 P28070 P28070 PSMB4 Proteasome subunit beta type-4 1 1415264000.0 23904000.0 290060000.0 1101300000.0 True False 36264115.61648392 238296526.75087613 883627572.2830626 1.0 6.571138512545389 24.36644482463011 25.11203933012512 -6.950032860385436 0.5584852778842172 0.7653899766215485 31.020447372869864 0.9992038421089443 0.28117359326837915 0.08347260829111837 0.035908154530734905 0.3019564191731339 1.4787893952612474 1.121933561295985e-07 6.950032860385436 30.255057396248315 EVLEK(ub)QPVLSQTEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVLEKQPVLSQTEAR 15 1 P28070 P28070 PSMB4 Proteasome subunit beta type-4 1 71237200.0 5358200.0 10035000.0 55844000.0 True False 7339271.339910415 9591620.518692637 42654797.343281835 1.0 1.3068900268796595 5.8118572495512195 22.80720540535172 -6.920690496573302 0.8195845470413656 0.9030541431404189 6.550000375539238 0.9943706974784997 0.16503065422736876 0.09776719008194634 0.10351989171451487 0.14271320005273944 0.4303600316734215 1.2003544405696881e-07 6.920690496573302 5.646946232398819 up EVLEK(ub)QPVLSQTEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVLEKQPVLSQTEAR 15 1 P28070 P28070 PSMB4 Proteasome subunit beta type-4 1 114505000.0 14387000.0 24392000.0 75726000.0 True False 11963427.952166634 24260595.45456707 91559956.48253584 1.0 2.0278966489845716 7.653321175888713 23.512127496974415 -6.93781166932781 0.6796165197395773 0.9338289703419793 9.0774019041544 0.9978630010574951 0.13518790818683266 0.08877930424052956 0.05926312271288783 0.12950787507046718 0.48902047526430215 1.1539535582946104e-07 6.93781166932781 8.14357293381242 EVLEK(ub)QPVLSQTEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVLEKQPVLSQTEAR 15 1 P28070 P28070 PSMB4 Proteasome subunit beta type-4 1 1166364000.0 23904000.0 220280000.0 922180000.0 True False 30944199.218284212 208021224.35831767 754352702.3658515 1.0 6.722462678413819 24.377838865519 24.88316565221757 -6.95081908549521 0.5497806582082693 0.755513260799748 31.1738958899517 0.9992639857809319 0.26993324182725764 0.08315855715087037 0.03461441394105875 0.2930617055394827 1.4646015657476275 1.1199043060148561e-07 6.95081908549521 30.418382629151953 EVLELGQVLDTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVLELGQVLDTGK 13 0 A0A0J9YYJ0;Q8N129 A0A0J9YYJ0 CNPY4 Protein canopy homolog 4 0 75661400.0 6878400.0 15191000.0 53592000.0 False True 9017649.01052035 12924562.014054202 48046813.93076407 1.0 1.4332518374773613 5.328086497346563 23.1043199270889 -6.927993127190548 0.763085231068795 0.9361516024816519 6.08829051771012 0.9961288807011046 0.12109022944162233 0.09369350506033437 0.08288406857209292 0.10902943339384358 0.35638405960077285 1.1803393146433998e-07 6.927993127190548 5.152138915228468 up EVLELGQVLDTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVLELGQVLDTGK 13 0 A0A0J9YYJ0;Q8N129 A0A0J9YYJ0 CNPY4 Protein canopy homolog 4 0 135194000.0 41210000.0 20450000.0 73534000.0 False True 39901811.107213534 28615791.64534119 54273239.427286044 1.0 0.717155208029341 1.3601698249098877 25.249950894771853 -6.787129064452476 1.5076733022012452 0.8413253978463041 1.3664881246648568 0.7919170452772898 0.12003494026677354 0.23966169454686018 1.0762258202673938 0.06267640062005478 0.14706050641154933 1.6325667065453273e-07 6.787129064452476 0.5251627268185527 EVLELGQVLDTGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVLELGQVLDTGK 13 0 A0A0J9YYJ0;Q8N129 A0A0J9YYJ0 CNPY4 Protein canopy homolog 4 0 544740000.0 48420000.0 391880000.0 104440000.0 False True 73456679.97616093 321945952.22758526 83797388.22232175 1.0 4.382800207306771 1.1407728779672144 26.130390356222183 -6.6361743329262515 2.057840166346754 3.2184411611388786 1.1539817474186056 0.1403295557662172 1.4487660827572142 0.5430196185184273 4.389871197889589 0.5742048517274045 1.6047536589770635 2.3111368757099194e-07 6.6361743329262515 -2.064459413720273 EVLELGQVLDTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVLELGQVLDTGK 13 0 A0A0J9YYJ0;Q8N129 A0A0J9YYJ0 CNPY4 Protein canopy homolog 4 0 98234400.0 6878400.0 16524000.0 74832000.0 False True 9421530.361770693 15793915.042439178 57158222.81341713 1.0 1.6763640763209142 6.066766291530025 23.16752998861179 -6.934193214123548 0.7115292901220058 0.9424871651732674 7.072551816136508 0.9973001252602832 0.11670875808596373 0.09051822392029006 0.06743691127372094 0.10911651493409051 0.38850447897741264 1.1636082342888221e-07 6.934193214123548 6.1300646509632415 EVLELGQVLDTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVLELGQVLDTGK 13 0 A0A0J9YYJ0;Q8N129 A0A0J9YYJ0 CNPY4 Protein canopy homolog 4 0 134951000.0 41210000.0 25479000.0 68262000.0 False True 34267940.91254513 25341739.569814503 82535268.59217258 1.0 0.7395174292639556 2.408527223821531 25.03035617020613 -6.867017168892085 1.1496850270358965 0.8550157491440435 2.500917417744147 0.9616183657587675 0.14363034319869764 0.13975093661671273 0.34709772939078715 0.09711700185601391 0.22882290566827923 1.3582597496672246e-07 6.867017168892085 1.6459016686001036 up EVLELGQVLDTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVLELGQVLDTGK 13 0 A0A0J9YYJ0;Q8N129 A0A0J9YYJ0 CNPY4 Protein canopy homolog 4 0 401320000.0 48420000.0 252520000.0 100380000.0 False True 62680644.500891946 238467040.0170797 82111869.98577738 1.0 3.804476516090806 1.3100036006268079 25.901516678314632 -6.618062638230876 2.124333943515489 2.86343199888894 1.3195124244653507 0.07613756720657316 1.2066336166704474 0.590654704350111 5.062499130222628 0.4672135899289675 1.3378456371445826 2.4095578734365585e-07 6.618062638230876 -1.5439195744235892 EVLEYNAIGGK(ub)YNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVLEYNAIGGKYNR 14 1 P14324;P14324-2;A0A087WVN4;A0A087X1D8 P14324 FDPS Farnesyl pyrophosphate synthase 1 143056200.0 23296600.0 32767500.0 86992100.0 True False 30542068.20459534 27878716.7267146 77990991.97914638 1.0 0.9127972781659883 2.5535596167456633 24.86429442403736 -6.894351448570738 0.9962679372561151 0.9208145874114736 2.707333965982984 0.9835410191015462 0.0967005289417624 0.1156841539682765 0.2017839633668044 0.07350019016172882 0.18635673749770554 1.2754062810013117e-07 6.894351448570738 1.7865193785715103 up EVLEYNAIGGK(ub)YNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVLEYNAIGGKYNR 14 1 P14324;P14324-2;A0A087WVN4;A0A087X1D8 P14324 FDPS Farnesyl pyrophosphate synthase 1 255045800.0 22685600.0 31738200.0 200622000.0 True False 21965458.045469645 44411428.77252655 148073079.66900992 1.0 2.02187583252726 6.741178779995888 24.38873324846067 -6.941591141806617 0.6445902940877022 0.9481393460079222 8.075697096821527 0.9983649791590918 0.10111290109825206 0.08704816867559516 0.051359773520353674 0.09965573115987209 0.403418839599426 1.143954782254231e-07 6.941591141806617 7.1275577508136045 EVLEYNAIGGK(ub)YNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVLEYNAIGGKYNR 14 1 P14324;P14324-2;A0A087WVN4;A0A087X1D8 P14324 FDPS Farnesyl pyrophosphate synthase 1 634985100.0 28393100.0 140319000.0 466273000.0 True False 43074408.513654225 115277978.13264902 374113937.1752844 1.0 2.6762521439175857 8.685294820860824 25.360327650092366 -6.947394489114015 0.5867517858262222 0.929842095612291 10.732389017750016 0.9989806294800575 0.10534606301596633 0.084549170411391 0.04042463721637022 0.10958512988947068 0.5029257013952075 1.1287701364320995e-07 6.947394489114015 9.802546922137726 EVLEYNAIGGK(ub)YNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVLEYNAIGGKYNR 14 1 P14324;P14324-2;A0A087WVN4;A0A087X1D8 P14324 FDPS Farnesyl pyrophosphate synthase 1 192557100.0 23296600.0 18940500.0 150320000.0 True False 31909982.5869428 18103646.082142316 114817511.93757848 1.0 0.5673348781315262 3.5981690564933277 24.927504485560252 -6.870713207491409 1.1303919260146833 0.7542404596847062 3.778033748070293 0.965385981727324 0.24902116783648126 0.1361688989350066 0.3247714244322164 0.17090001099228877 0.40509858226644735 1.346749405508035e-07 6.870713207491409 3.023793288385587 up EVLEYNAIGGK(ub)YNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVLEYNAIGGKYNR 14 1 P14324;P14324-2;A0A087WVN4;A0A087X1D8 P14324 FDPS Farnesyl pyrophosphate synthase 1 282433400.0 22685600.0 44133800.0 215614000.0 True False 18864081.542480815 43896042.459526554 260697890.51350242 1.0 2.326964202348003 13.819802990483577 24.169138523894947 -6.928650352024422 0.7577954895867927 0.8161933822968622 16.10007580844944 0.9962661350269574 0.3517281718830379 0.09334485610549435 0.08115996498806428 0.317904636238793 1.0477290250963738 1.1785544390300578e-07 6.928650352024422 15.283882426152577 EVLEYNAIGGK(ub)YNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVLEYNAIGGKYNR 14 1 P14324;P14324-2;A0A087WVN4;A0A087X1D8 P14324 FDPS Farnesyl pyrophosphate synthase 1 555549100.0 28393100.0 116311000.0 410845000.0 True False 36755427.661674455 109838190.6044139 336075425.6256897 1.0 2.9883529479088105 9.143559115110543 25.131453972184815 -6.950743080660441 0.5506250906503578 0.9151890832245284 11.5061958997952 0.9992583164675816 0.09440972118161088 0.08318871940882323 0.03473801712531063 0.1023879622399622 0.5106869793405002 1.1201003149301848e-07 6.950743080660441 10.591006816570673 EVLLVALGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVLLVALGSR 10 0 Q10570 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 0 3516520.0 951220.0 1079100.0 1486200.0 False True 921024.041771503 1509990.2574321593 1096919.6349557014 1.0 1.6394688834917222 1.1909782863494853 19.812879290353663 -10.25604443106877 4.158062011288264 0.9996655804771343 1.415223584942 0.5333357010289658 0.18309551964321144 130442498.25378358 69959904.09689617 445771.41447499854 0.0670060993640181 5.545689741465375e-11 10.25604443106877 0.4155580044648658 EVLLVALGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVLLVALGSR 10 0 Q10570 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 0 5320200.0 1316100.0 1433800.0 2570300.0 False True 1802697.7362651778 1370449.97505745 1963248.07699014 1.0 0.7602217207510023 1.0890611540110933 20.781726085368874 -6.711213345344943 1.791035514621313 0.8527711846710873 1.0883112364733831 0.4707930134316525 0.10102234786438063 0.37264169040877937 2.3309341879020713 0.04487509884558961 0.11382979127980837 1.9444046663229208e-07 6.711213345344943 0.23554005180229587 EVLPALENNK(ub)EQIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVLPALENNKEQIQK 15 1 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 1 11258400.0 1875800.0 3331000.0 6051600.0 True False 2569333.951588958 3183825.405856026 4622336.7166142175 1.0 1.239163715517419 1.799040842376919 21.292962987390602 -6.956854405735439 0.4777095719174892 0.9862673840016539 2.075189641355673 0.9996351462696466 0.006396038672173321 0.0808445741400945 0.025433303604906983 0.007857797206734334 0.04618925563675723 1.1044488167826396e-07 6.956854405735439 1.0889222573540192 EVLPALENNK(ub)EQIQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVLPALENNKEQIQK 15 1 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 1 9397000.0 3468800.0 3920800.0 2007400.0 True False 2884460.8938955716 3899677.8721821345 2427138.0588310836 1.0 1.3519607356907082 0.8414529259064225 21.459870273504777 -6.721218742289062 1.755103026161561 1.2138506838153873 0.842202894839108 0.5181987242723867 0.14808447417990206 0.3529480274223626 2.12546030531639 0.06697949649201129 0.16789204335282407 1.9001209997267057e-07 6.721218742289062 -0.37164778897627926 EVLTLQLGHFAGFVGAHWWNQQDAALGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVLTLQLGHFAGFVGAHWWNQQDAALGR 28 0 A0A3B3IUD2;Q9BUK6-7;Q9BUK6-3;Q9BUK6-2;Q9BUK6;Q9BUK6-4 A0A3B3IUD2 MSTO1 Protein misato homolog 1 0 64091000.0 17534000.0 25402000.0 21155000.0 False True 26600359.90710461 20868814.63326812 16973704.977434125 1.0 0.7845312885294583 0.6381005759587737 24.664942429963652 -7.870556872208173 0.08283802390439132 1.55031660176801 0.00024357165569295375 0.9999964703463986 0.00027919248909667683 0.12569587784311323 0.011830072645202834 0.09896317459635791 0.11550277762330212 1.3472342892873157e-08 7.870556872208173 -1.550073030112317 EVLTLQLGHFAGFVGAHWWNQQDAALGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVLTLQLGHFAGFVGAHWWNQQDAALGR 28 0 A0A3B3IUD2;Q9BUK6-7;Q9BUK6-3;Q9BUK6-2;Q9BUK6;Q9BUK6-4 A0A3B3IUD2 MSTO1 Protein misato homolog 1 0 30790500.0 17534000.0 5048400.0 8208100.0 False True 22698108.64681204 4767452.102099744 6714310.022218163 1.0 0.21003741660957 0.2958092291606504 24.4360687520561 -10.515668103341817 6.258721487303349 1.0006951311169032 0.25292332304801873 0.9902107876985572 0.03501619584396552 0.0003399251013330447 2.630509167467259e-05 0.0339324086718995 0.011301428612601312 3.050225143105735e-11 10.515668103341817 -0.7477718080688844 EVMLILIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVMLILIR 8 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 3916700.0 1114300.0 1268400.0 1534000.0 False True 1460858.0908965506 1079159.6641844753 1375276.3951670418 1.0 0.7387162866190369 0.9414168314754063 20.478384609544033 -10.59106846506763 5.4705721030684344 1.000926509409013 0.8400665590472215 0.45356867474900564 0.08275215091370687 0.0009404021158911423 7.029595691339596e-05 0.0805777060632482 0.02670814186263573 2.5640797860806683e-11 10.59106846506763 -0.16085995036179146 EVMLILIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVMLILIR 8 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 5186900.0 1114300.0 1514900.0 2557700.0 False True 1526286.8228252344 1447966.7088956132 1953623.9374849938 1.0 0.9486858480605587 1.2799848025083103 20.541594671066925 -6.867355607196475 1.1480641752327814 0.9713973377641275 1.2984308072501343 0.9619681302201677 0.02839377444929876 0.13941173784994784 0.3450975004609453 0.019223887417932913 0.045313492918139346 1.357201693258305e-07 6.867355607196475 0.32703346948600676 EVNAVDSEHEK(ub)NVMNDAWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVNAVDSEHEKNVMNDAWR 19 1 A0A3B3ISG5;P14735;Q5T5N3 A0A3B3ISG5 IDE Insulin-degrading enzyme 1 36498800.0 10228900.0 11938400.0 14331500.0 True False 13410186.956808493 10157237.25551873 12848613.857455317 1.0 0.7574269686346017 0.9581233952097842 23.67682601478579 -10.03209209466253 6.063706273546052 1.0000001922498758 0.8577751820706836 0.40105125946803144 0.0819339730515521 2.1293035869036728e-07 3.3922045736210494e-08 0.07933233585380345 0.026444076093101693 9.287694149575667e-11 10.03209209466253 -0.1422250101791922 EVNAVDSEHEK(ub)NVMNDAWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVNAVDSEHEKNVMNDAWR 19 1 A0A3B3ISG5;P14735;Q5T5N3 A0A3B3ISG5 IDE Insulin-degrading enzyme 1 42225000.0 11248600.0 12571700.0 18404700.0 True False 10891519.35017234 17591645.37054943 13583956.940835152 1.0 1.6151690875223088 1.2472049586562235 23.37670188604087 -10.28485284032649 4.965218440551258 0.9998787159147473 1.431187023089496 0.6467525599322139 0.1502207265623999 0.00020174132146166262 2.9057060482216345e-05 0.14549122033855585 0.04848353101916565 5.1897586290070403e-11 10.28485284032649 0.4313083071747488 EVNAVDSEHEK(ub)NVMNDAWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVNAVDSEHEKNVMNDAWR 19 1 A0A3B3ISG5;P14735;Q5T5N3 A0A3B3ISG5 IDE Insulin-degrading enzyme 1 107749000.0 42382000.0 34053000.0 31314000.0 True False 64296592.53923277 27975976.092696592 25124774.17458621 1.0 0.4351082225022437 0.3907636965249048 25.938238946756815 -13.999999999999998 0.3607815149370221 8.42725981424026 0.38548380806573285 0.9997747016603811 0.004162795254988131 21.78129247661076 0.1941822539999785 124.60497974355663 0.012763609263069303 1.0000000000000041e-14 13.999999999999998 -8.041776006174528 EVNAVDSEHEK(ub)NVMNDAWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVNAVDSEHEKNVMNDAWR 19 1 A0A3B3ISG5;P14735;Q5T5N3 A0A3B3ISG5 IDE Insulin-degrading enzyme 1 44284800.0 10228900.0 16518200.0 17537700.0 True False 14010800.75562866 15788371.305617232 13395656.460269239 1.0 1.1268714458932303 0.956094993706031 23.74003607630868 -6.707703403653033 1.8029362957780237 1.078175605776519 0.9565140252843536 0.4544677601228714 0.05348198862340298 0.37967314551045445 2.4042228710131153 0.023616832517145733 0.06017577066311698 1.9601829005217315e-07 6.707703403653033 -0.12166158049216547 EVNAVDSEHEK(ub)NVMNDAWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVNAVDSEHEKNVMNDAWR 19 1 A0A3B3ISG5;P14735;Q5T5N3 A0A3B3ISG5 IDE Insulin-degrading enzyme 1 32867600.0 11248600.0 14955000.0 6664000.0 True False 9353709.297472825 14874434.446664928 8057411.589145337 1.0 1.5902177386123904 0.8614135133879219 23.157107161475146 -6.6912966685462765 1.8623820601957797 1.369583614310473 0.8639292452943097 0.37633379500059916 0.24955527960837526 0.41383614073805347 2.784089567143506 0.10717102403199164 0.27856653744041304 2.0356510401148015e-07 6.6912966685462765 -0.5056543690161632 EVNAVDSEHEK(ub)NVMNDAWR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 EVNAVDSEHEKNVMNDAWR 19 1 A0A3B3ISG5;P14735;Q5T5N3 A0A3B3ISG5 IDE Insulin-degrading enzyme 1 113206400.0 51150100.0 29650700.0 32405600.0 True False 66214812.769208506 28000612.479939967 26508113.30953483 1.0 0.4228753553609825 0.4003350942322946 25.980650659463794 EVNGHEVGNNPK(ub)ELQELLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVNGHEVGNNPKELQELLK 19 1 B8ZZG1;Q9NZW5;C9J4Q3;C9JGI8 B8ZZG1 MPP6 MAGUK p55 subfamily member 6 1 7965400.0 3071100.0 1668400.0 3225900.0 True False 2973609.6115351515 2334600.8205910614 2380940.0150744123 1.0 0.7851066971046693 0.8006901799880959 21.50378382583654 -10.237551918618598 5.400863451652747 1.0000157872103936 0.7928984385463631 0.9957715262903544 0.00636193024670135 1.2094595609508138e-06 1.7074483860315282e-07 0.006160381767030992 0.002053304157923897 5.786928032036727e-11 10.237551918618598 -0.20711734866403053 EVNGHEVGNNPK(ub)ELQELLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVNGHEVGNNPKELQELLK 19 1 B8ZZG1;Q9NZW5;C9J4Q3;C9JGI8 B8ZZG1 MPP6 MAGUK p55 subfamily member 6 1 14800400.0 5444200.0 5718500.0 3637700.0 True False 7047624.221225863 5400260.448034502 2975675.925953996 1.0 0.7662526091800026 0.4222239768391634 22.748705571246102 -6.965570771722556 0.348117739638066 1.0339745528203448 0.14292674127302143 0.9999244313983428 0.0020628803656237084 0.07776781040573462 0.014180011843253095 0.0047454153670874605 0.02960749681923067 1.0825032982747343e-07 6.965570771722556 -0.8910478115473234 down EVNK(ub)FQMAYSNLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVNKFQMAYSNLLR 14 1 P37108 P37108 SRP14 Signal recognition particle 14 kDa protein 1 5562600.0 0.0 4040500.0 1522100.0 True False 0.0 3437673.149745639 1364607.6930141812 0.0 EVNK(ub)FQMAYSNLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVNKFQMAYSNLLR 14 1 P37108 P37108 SRP14 Signal recognition particle 14 kDa protein 1 22850200.0 8910600.0 10878000.0 3061600.0 True False 8627737.880415838 15221642.128020585 2259675.1139687607 1.0 1.7642680316670603 0.26190817863138993 23.040550915923543 -6.768358474492275 1.5804477731025373 1.439247226407024 0.25389404493790835 0.7244590317893604 0.3219685166716561 0.26902904465484123 1.3258878216990828 0.16059445964127234 0.38290506256239426 1.704674738881811e-07 6.768358474492275 -1.1853531814691156 EVNK(ub)FQMAYSNLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVNKFQMAYSNLLR 14 1 P37108 P37108 SRP14 Signal recognition particle 14 kDa protein 1 20227600.0 8910600.0 9914500.0 1402500.0 True False 7409558.706511148 9861088.620625839 1695756.2655726804 1.0 1.330860448134436 0.22886062891741918 22.82095619135782 -6.826212256483087 1.3447551472753982 1.1773042988087214 0.20143739778603967 0.8980823524932304 0.1473966218594081 0.1855329050324969 0.6574908337440304 0.0860920886031289 0.19818086099580476 1.492065001567948e-07 6.826212256483087 -0.9758669010226818 down EVNLAVQNAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVNLAVQNAK 10 0 P49189;P49189-3 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 3708800.0 1044900.0 1469900.0 1194000.0 False True 1369874.0188259957 1250596.6496253249 1070456.333656745 1.0 0.9129282199958114 0.7814268457869896 20.385611790413478 -6.965143846533573 0.3555785269268492 1.0119194922643813 0.6779599757920314 0.9999160718093053 0.0008230662807091619 0.07791223190184174 0.014688261984150677 0.0017810671441750006 0.01126232167672647 1.0835679564085803e-07 6.965143846533573 -0.3339595164723499 EVNLAVQNAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVNLAVQNAK 10 0 P49189;P49189-3 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 4556000.0 1044900.0 1452900.0 2058200.0 False True 1431227.7673607543 1388706.0739021956 1572095.549959578 1.0 0.9702900583483155 1.0984244337703075 20.44882185193637 -6.845653860169853 1.255785517425865 0.9841855677267408 1.1031354684916577 0.9337477780965328 0.014095096420958178 0.16230780394398375 0.4947291518383512 0.00879152525063164 0.020296647136561673 1.4267442791711247e-07 6.845653860169853 0.11894990076491685 EVPAVPETLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVPAVPETLK 10 0 P18124 P18124 RPL7 60S ribosomal protein L7 0 21429600.0 4651200.0 1166400.0 15612000.0 False True 4503550.201938164 1632149.602695647 11522748.850039298 1.0 0.3624139910760246 2.558592295713796 22.102631312852868 -6.829021057688283 1.3321728198994311 0.6590657547056562 2.616558228486768 0.9039152289503698 0.2859498898768496 0.18202801510687347 0.6321148141500923 0.16854539255513393 0.38790924775423574 1.4824462038576155e-07 6.829021057688283 1.957492473781112 up EVPAVPETLKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVPAVPETLKK 11 1 P18124 P18124 RPL7 60S ribosomal protein L7 1 3087700.0 3087700.0 0.0 0.0 True False 4048004.601329336 0.0 0.0 1.0 0.0 0.0 21.94877949925542 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 EVPAVPETLKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVPAVPETLKK 11 1 P18124 P18124 RPL7 60S ribosomal protein L7 1 6448600.0 0.0 6448600.0 0.0 True False 0.0 9023559.609004756 0.0 0.0 EVPAVPETLKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVPAVPETLKK 11 1 P18124 P18124 RPL7 60S ribosomal protein L7 1 12440800.0 0.0 9127000.0 3313800.0 True False 0.0 9077831.039432349 4006700.258719958 0.0 EVPK(ub)QQAAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVPKQQAAYR 10 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 6096400.0 2007600.0 2313100.0 1775700.0 True False 2631983.0416260576 1967994.4963931818 1591967.597717152 1.0 0.7477230913985453 0.6048548081577392 21.327718762865107 -13.999999999602876 0.06578115889027825 2.514721282891092 0.03807819613328281 0.9999380018255359 0.0012863096830378164 12.404184154206085 0.06777560276500592 2.9639436016379386 0.5257201992062026 1.000000000914412e-14 13.999999999602876 -2.476643086757809 EVPK(ub)QQAAYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVPKQQAAYR 10 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 6630700.0 2611000.0 2141500.0 1878200.0 True False 2528115.2341891397 2996612.117774969 1386243.0752077752 1.0 1.1853146871036888 0.5483306522031994 21.269630793916832 -6.828862975358889 1.3330949128894534 1.099096827975741 0.531597159350712 0.9035680542513553 0.08307384385290703 0.18221249111247934 0.633720576363111 0.04893590835241517 0.11261495787439535 1.4829859095532957e-07 6.828862975358889 -0.567499668625029 EVPK(ub)QQAAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVPKQQAAYR 10 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 5839900.0 2007600.0 1615600.0 2216700.0 True False 2749863.9733500327 1544217.4499252466 1693161.1143695468 1.0 0.5615613953602212 0.6157254070668982 21.390928824388 -10.053895653722824 4.988620840558891 1.000007842645945 0.5886434012115069 0.987163836501585 0.02211236519344445 1.928784997368241e-06 3.6582470720972907e-07 0.0214106134040083 0.007136735176926042 8.832921001461211e-11 10.053895653722824 -0.4113644414344382 EVPK(ub)QQAAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVPKQQAAYR 10 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 6896700.0 2611000.0 2878100.0 1407600.0 True False 2171162.1869122847 2862595.10404188 1701922.651992944 1.0 1.31846212194443 0.7838763323403909 21.05003606935111 -6.745326406929721 1.6670326079570768 1.1883038647319943 0.783174112937112 0.6286707318411975 0.13380055960978463 0.3082653821530227 1.6839359138597723 0.06344384654119277 0.15479446679317418 1.7975194281496916e-07 6.745326406929721 -0.4051297517948823 EVPNTVHQFQLDITVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVPNTVHQFQLDITVK 16 0 A0A2Y9D025;P56556 A0A2Y9D025 NDUFA6 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 0 30852500.0 6423500.0 10538000.0 13891000.0 False True 9744919.120753186 8657411.566230202 11145437.761358403 1.0 0.8884026084724518 1.1437178311334175 23.216218781018473 -6.787948712002982 1.5049893800810124 0.9374605971399466 1.1462641193702021 0.7944548228607511 0.04738024926081887 0.23842964222807042 1.0669736735493216 0.024785514479941248 0.05810516563911549 1.6294884556797213e-07 6.787948712002982 0.20880352223025556 EVPNYK(ub)LITPAVVSER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVPNYKLITPAVVSER 16 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 24334500.0 5752400.0 7025100.0 11557000.0 True False 7541452.106320834 5976982.463625326 10361192.502572022 1.0 0.7925506095325786 1.3738988667564216 22.84641091044199 -6.810205572247799 1.4135338641589987 0.8869688696247734 1.3841307029771504 0.8603994982001079 0.08987901601895903 0.2065177594557694 0.813216267407007 0.04999490272631316 0.11564502526847042 1.5480836637783913e-07 6.810205572247799 0.49716183335237696 EVPNYK(ub)LITPAVVSER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVPNYKLITPAVVSER 16 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 44144000.0 10483000.0 10850000.0 22811000.0 True False 10150222.90310409 15182461.582002526 16836114.784668617 1.0 1.4957761742709614 1.6586940942469237 23.27500807415123 -11.539562580322157 0.19768851556136585 2.976649007270201e-09 1.7835835307297048 0.9993974660108258 0.006876027141879676 4.173194258749036 0.11830840880287365 1.886190261638179 0.10426179623866064 2.8869377515409976e-12 11.539562580322157 1.7835835277530558 EVPNYK(ub)LITPAVVSER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVPNYKLITPAVVSER 16 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 63392500.0 8028500.0 10483000.0 44881000.0 True False 12179821.461970413 8612226.745947162 36010250.677958906 1.0 0.7070897363181794 2.9565499617868194 23.5379896498517 -6.8741527520143 1.1119446318167179 0.8293705562807109 3.0990885125840713 0.9686524640673051 0.1767959877700354 0.1329329435566141 0.30469074371304883 0.12306044412710188 0.29363098414867883 1.3361254858074217e-07 6.8741527520143 2.2697179563033605 up EVPNYK(ub)LITPAVVSER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVPNYKLITPAVVSER 16 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 26496100.0 5752400.0 6938700.0 13805000.0 True False 7879217.732764843 6632125.290787504 10544543.322899606 1.0 0.8417238253498891 1.3382728692787997 22.90962097196488 -6.820950956517644 1.3676688107953592 0.9147706912017879 1.3493437595543027 0.8865775251818889 0.06975011475322451 0.19224612225806337 0.7063203958584187 0.04007314086048969 0.09234344521011033 1.5102506922996693e-07 6.820950956517644 0.43457306835251486 EVPNYK(ub)LITPAVVSER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVPNYKLITPAVVSER 16 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 44733000.0 10483000.0 20477000.0 13773000.0 True False 8717078.97564209 20366686.33663372 16652870.620843144 1.0 2.336411817943124 1.9103728057731073 23.055413349585507 -10.12923590301678 4.853835721964914 0.9999333215411423 2.123392311864264 0.9026337031358331 0.17392969841053124 0.00012550796586094696 2.25156258131629e-05 0.1684166055754726 0.05613556877655232 7.426156493260144e-11 10.12923590301678 1.1234589903231218 EVPNYK(ub)LITPAVVSER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVPNYKLITPAVVSER 16 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 46040500.0 8028500.0 13850000.0 24162000.0 True False 10393051.51539468 13079235.324871534 19764763.923055936 1.0 1.2584595876868263 1.9017286591699687 23.30911597194415 -6.955557497748517 0.4940837752676154 0.9864297438006913 2.2012255721048315 0.9995683041792912 0.007877459726332258 0.08132797558611439 0.02729884284783387 0.009344360311425466 0.05305637957282602 1.1077518965606337e-07 6.955557497748517 1.2147958283041402 EVQEFYK(ub)DTYNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVQEFYKDTYNK 12 1 A6NNI4;A0A2R8Y478;G8JLH6;P21926;A0A087WU13 A6NNI4 CD9 Tetraspanin;CD9 antigen 1 32426800.0 2203800.0 14966000.0 15257000.0 True False 3343325.719361076 12295200.370108278 12241447.262619337 1.0 3.67753590351883 3.6614581677548097 21.672852483901334 -10.175343357065419 4.905213780869488 0.9997593907532741 3.669497035643554 0.9999727955045711 0.0065637081634649305 1.727258465450142e-05 2.9038081216958183e-06 0.006355807631620662 0.002118427697219063 6.678157277688659e-11 10.175343357065419 2.66973764489028 EVQEFYK(ub)DTYNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVQEFYKDTYNK 12 1 A6NNI4;A0A2R8Y478;G8JLH6;P21926;A0A087WU13 A6NNI4 CD9 Tetraspanin;CD9 antigen 1 29662800.0 2203800.0 12825000.0 14634000.0 True False 2852862.5433925143 12111277.475918954 11970762.157520091 1.0 4.245307052724906 4.196052903160529 21.443978805993783 -10.172490826614622 4.369529767027647 0.9992208416981924 4.220679978067874 0.9998246217839465 0.020107922787349856 1762163.9481750012 20.555226342882175 13829.849972685604 0.0068834767458411505 6.72216507855082e-11 10.172490826614622 3.221459136369682 EVQMHSFPLQFTLHCALLANK ddPTM_RPMI8226_Bortezomib_8h_R1 2 EVQMHSFPLQFTLHCALLANK 21 0 P42704;B8ZZ38;A0A0C4DG06 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 243245400.0 77570000.0 67366400.0 98309000.0 False True 117679361.12661722 55344339.58391438 78878183.05963467 1.0 0.47029775700742105 0.6702805173692744 26.81028607853063 -10.129131609179977 5.2354627930826245 1.0000118516078973 0.5702891371879907 0.8602592502339528 0.08164262004122162 1.1294336832165396e-05 1.8787890980364e-06 0.07905230568341926 0.026350042313185783 7.42794006498325e-11 10.129131609179977 -0.4297227144199066 EVQMHSFPLQFTLHCALLANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVQMHSFPLQFTLHCALLANK 21 0 P42704;B8ZZ38;A0A0C4DG06 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 7599730.0 987770.0 836360.0 5775600.0 False True 1352975.262480555 799406.8497273321 4411522.2322157975 1.0 0.5908510465015403 3.260608197763852 20.367704030942477 -6.867808831459811 1.1456882156384556 0.771419996829851 3.4105445242195054 0.9624435403603211 0.22752319399221957 0.13896966901118685 0.342306021278026 0.15432404003776784 0.3640250439667263 1.3557860734178108e-07 6.867808831459811 2.6391245273896544 up EVQMHSFPLQFTLHCALLANK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVQMHSFPLQFTLHCALLANK 21 0 P42704;B8ZZ38;A0A0C4DG06 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 102113900.0 45074000.0 36351000.0 20688900.0 False True 58349181.54137146 34328034.89490289 16923732.486040544 1.0 0.5883207611157871 0.2900423285978925 25.798209083734804 -8.02813991058494 0.23705406936382067 1.196793194745459 2.6815406239504584e-09 0.9996726090254587 0.005266581757893633 0.09841884057622008 0.04387401096842658 0.0733106100041543 0.09888374888286615 9.372600143214227e-09 8.02813991058494 -1.1967931920639185 down EVQQK(ub)IEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVQQKIEK 8 1 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 1 12329400.0 4032100.0 5458200.0 2839100.0 True False 5286122.146911938 4643857.835896962 2545337.1665702397 1.0 0.8784999110566949 0.48151311979371914 22.333778331176173 -6.949517329868576 0.5641196577007105 1.0050844112160162 0.3358213952656347 0.9991628447200539 0.006406106116580345 0.08368018097137403 0.03676925128919606 0.006833307461402563 0.033030693171890606 1.123266146532669e-07 6.949517329868576 -0.6692630159503815 down EVQQK(ub)IEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVQQKIEK 8 1 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 1 13407800.0 5451400.0 5599500.0 2356900.0 True False 5278348.2909454955 7835409.5510067465 1739557.1845156038 1.0 1.4844434506998423 0.3295646836150712 22.331655119124683 -6.792746500612236 1.4852793389962387 1.2697864546224427 0.3163229235231479 0.8101365686964648 0.20632446505433547 0.23127047482680083 1.0078128609668067 0.10932318485311682 0.2554567802593389 1.6115860497704564e-07 6.792746500612236 -0.9534635310992947 down EVQQK(ub)IEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVQQKIEK 8 1 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 1 4976500.0 1669500.0 1066700.0 2240300.0 True False 2532753.5567988586 876339.0508348593 1797503.7230416278 1.0 0.34600249537995403 0.7097033654207907 21.272275275399 -10.697338037887596 6.919061135973344 1.0038013746932248 0.527852930400601 0.6920241819480998 0.1484802584343912 0.008744793435788533 0.00038252467928168274 0.14439277791426328 0.04792179734641418 2.0075296215587122e-11 10.697338037887596 -0.47594844429262384 EVQQK(ub)IEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVQQKIEK 8 1 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 1 10924600.0 4032100.0 3944200.0 2948300.0 True False 5522876.333405382 3769932.2022747872 2251972.26214451 1.0 0.6826030449880204 0.4077535193977363 22.396988392699065 -7.285194243250952 0.20821042710082432 1.1683017941509355 1.0272805170784457e-11 0.9999763137917412 0.0011777216756829305 0.10449952230511776 0.012448759971932708 0.017739968685536192 0.04557253921417935 5.1856805146958654e-08 7.285194243250952 -1.1683017941406626 down EVQQK(ub)IEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVQQKIEK 8 1 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 1 12231900.0 5451400.0 5089200.0 1691300.0 True False 4533080.637967691 5061783.469472894 2044943.0103123526 1.0 1.1166321258609324 0.45111551583365583 22.11206039455896 -6.861659488532658 1.1772287549188953 1.0635862667690699 0.4178370263040554 0.9556315777246179 0.06112094398991685 0.14510727666204407 0.38117431196766893 0.04046452717582513 0.0946457160153515 1.3751197241841077e-07 6.861659488532658 -0.6457492404650145 down EVQQK(ub)IEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVQQKIEK 8 1 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 1 3512480.0 1669500.0 1132600.0 710380.0 True False 2161200.660764956 1069569.8143645853 581098.1291143307 1.0 0.49489611667341044 0.26887745301199906 21.04340159749145 -10.843214573474128 0.16102416162953714 1.9428333055722737 7.694440459568346e-23 0.9996027424228193 0.006091850793906194 2.8787223354203655 0.08981111948969935 1.21317400759022 0.18801415916809347 1.4347803709815367e-11 10.843214573474128 -1.9428333055722737 EVQTNDLK(ub)EVVNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVQTNDLKEVVNK 13 1 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 10486600.0 2362800.0 3986600.0 4137200.0 True False 3097653.6813877514 3391814.819645085 3709122.230824689 1.0 1.094962564738854 1.1973973246625165 21.56274442872831 -6.970159538172947 0.2543633319375203 0.9691881078708554 1.3261886814121342 0.9999835903162431 0.00032647620745357707 0.07625106872851965 0.008845517323628182 0.002218770107865639 0.009748927014382321 1.0711257546762567e-07 6.970159538172947 0.3570005735412788 EVQTNDLK(ub)EVVNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVQTNDLKEVVNK 13 1 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 51490800.0 5265700.0 8882900.0 37342200.0 True False 7988451.874235256 7297677.092585516 29961497.80233232 1.0 0.9135283290774199 3.75060127719685 22.929484511805587 -6.899868456818731 0.9620830182325792 0.8816188229409503 4.047622420308634 0.9865012225133137 0.1530727911574352 0.11150270858826238 0.17795946759685516 0.11935786862311536 0.3103498509472601 1.2593067846708302e-07 6.899868456818731 3.166003597367683 up EVQTNDLK(ub)EVVNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVQTNDLKEVVNK 13 1 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 13310400.0 2362800.0 3206300.0 7741300.0 True False 3236391.0122691067 3064635.06418378 5912964.377078077 1.0 0.9469297907965377 1.8270241001974494 21.6259544902512 -6.892561835618504 1.007068765959755 0.9555747715766163 1.906642243351937 0.9824891976231453 0.05332232550219322 0.11709059032206788 0.20988597843544748 0.04020068344475495 0.10119448688118826 1.2806727370989674e-07 6.892561835618504 0.9510674717753207 EVQTNDLK(ub)EVVNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVQTNDLKEVVNK 13 1 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 12569600.0 3583900.0 3842100.0 5143600.0 True False 2980171.6436901316 3821401.8447028566 6219102.978680667 1.0 1.2822757550874118 2.0868271100586675 21.5069639947664 -6.952596397080613 0.5295778258235744 0.9872724217129099 2.418327225314906 0.9993895757894514 0.011376370813882507 0.08245969956313849 0.03177557265291458 0.012699951128801422 0.0665284262459934 1.1153305623355749e-07 6.952596397080613 1.431054803601996 up EVQTNDLK(ub)EVVNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVQTNDLKEVVNK 13 1 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 48276700.0 5265700.0 8439500.0 34571500.0 True False 6816552.452464831 7969834.40608327 28279841.73354552 1.0 1.16918845144387 4.148701551224721 22.700610833898036 -6.918585869613443 0.8351447931622514 0.930846013775625 4.613890721199639 0.9937789308806692 0.11405811667195304 0.0990115537113783 0.10997804030653911 0.09754329199843809 0.28835415890503363 1.2061855750830522e-07 6.918585869613443 3.6830447074240142 up EVSFQSTGESEWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVSFQSTGESEWK 13 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 29811000.0 12959000.0 0.0 16852000.0 False True 12547623.63839798 0.0 12437955.650836684 1.0 0.0 0.9912598599765383 23.580910826019245 -11.988032423841593 10.918582232431573 0.869183751563658 0.5460669369889314 0.0 0.48388740565016886 0.0 0.0 0.0 0.13845180291905168 1.0279395506780123e-12 11.988032423841593 -0.32311681457472663 EVSGIK(ub)AAYEAELGDAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVSGIKAAYEAELGDAR 17 1 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 18051400.0 5607700.0 8573600.0 3870100.0 True False 7351749.005044053 7294452.2996310415 3469659.1766205784 1.0 0.9922063844435248 0.47195016780905286 22.809656081957716 -6.910159574699183 0.8946482829207979 1.0160269839900795 0.4044859952057447 0.9909816251847784 0.023466697224799025 0.10431257346592923 0.13819590246799512 0.01922766852419359 0.053135870809706165 1.2298168108766663e-07 6.910159574699183 -0.6115409887843348 down EVSGIK(ub)AAYEAELGDAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVSGIKAAYEAELGDAR 17 1 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 38371520.0 13727100.0 13549420.0 11095000.0 True False 13291340.724334648 18959774.06529184 8188886.6571346335 1.0 1.4264756625025088 0.616106894479192 23.663983303723242 -6.763710675585279 1.598475578038636 1.2465760848933756 0.6125883645023351 0.7059339295635897 0.17948547098546375 0.27673140427612003 1.3943604897102109 0.08855977768111378 0.21205302420643524 1.7230160558247698e-07 6.763710675585279 -0.6339877203910405 EVSGIK(ub)AAYEAELGDAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVSGIKAAYEAELGDAR 17 1 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 23662700.0 5607700.0 11520000.0 6535000.0 True False 7681018.23239439 11011008.308454342 4991567.592549731 1.0 1.4335349787370444 0.6498575373116539 22.872866143480607 -6.7565764091669385 1.6257823391517896 1.2528965603451763 0.6475101276602196 0.676668560316255 0.18226520367846188 0.28870756763303074 1.5032487832492152 0.08849750084254245 0.2133626271138368 1.75155424108148e-07 6.7565764091669385 -0.6053864326849566 EVSGIK(ub)AAYEAELGDAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVSGIKAAYEAELGDAR 17 1 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 33851700.0 13727100.0 15354000.0 4770600.0 True False 11414691.863639848 15271284.954469604 5768110.403237807 1.0 1.3378622162473328 0.5053233562625935 23.44438857915752 -6.79658547332992 1.4703034695799466 1.1872294105275687 0.4948391262477701 0.8218426027590088 0.14430579052467565 0.22567527371169901 0.9635542490822026 0.07723316828819958 0.17996346887277945 1.5974031138273392e-07 6.79658547332992 -0.6923902842797987 EVSMK(ub)AEDAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVSMKAEDAQR 11 1 O75695 O75695 RP2 Protein XRP2 1 5252900.0 1937900.0 2180000.0 1135000.0 True False 2540605.6666502976 1854752.4975734442 1017561.0876887817 1.0 0.7300434388225515 0.40051909709797723 21.276741038018805 -6.968455474510433 0.29274013022938655 1.0623126870649156 0.05802986531640882 0.999967701202253 0.0013931653769929616 0.07680715274231006 0.010814871917857604 0.005673655749110491 0.029789262666393958 1.0753368422839262e-07 6.968455474510433 -1.0042828217485067 down EVSMK(ub)AEDAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVSMKAEDAQR 11 1 O75695 O75695 RP2 Protein XRP2 1 2559980.0 1189300.0 941960.0 428720.0 True False 1151546.3224899063 1318089.540256507 316425.37067568797 1.0 1.1446257215311115 0.27478301523424953 20.135141015958453 -6.864175016103399 1.1643818872893315 1.0795284185754113 0.22915908589502515 0.9585205392177204 0.07750824718279999 0.14256702798155083 0.36493580075647025 0.0518207338236448 0.12159869933092798 1.367177756325348e-07 6.864175016103399 -0.8503693326803861 down EVSMK(ub)AEDAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EVSMKAEDAQR 11 1 O75695 O75695 RP2 Protein XRP2 1 8342860.0 3757800.0 2484300.0 2100760.0 True False 5147160.210726615 2374535.4115184997 1604603.7545102916 1.0 0.46132922122183 0.3117454458025842 22.295345257954416 -13.999999999999998 0.17975882909039578 3.7928561305324395 0.19262697197991704 0.9994984307987008 0.006619427509955068 12.201614754983249 0.13440224926802252 11.901565185747325 0.11191382312730179 1.0000000000000041e-14 13.999999999999998 -3.6002291585525223 EVSQPDWTPPPEVTLVLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVSQPDWTPPPEVTLVLTK 19 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 15333100.0 3893100.0 7598100.0 3841900.0 False True 5103891.800834028 6464493.097161829 3444377.0421070745 1.0 1.2665811403183478 0.6748530683084285 22.28316631456043 -6.784223774614098 1.5193042928771612 1.1501181666005675 0.6695208140187152 0.7820768918564849 0.11295516239510048 0.24407159223550132 1.1129838447419758 0.058540494308804175 0.13765789562083877 1.6435246623388995e-07 6.784223774614098 -0.4805973525818523 EVSQPDWTPPPEVTLVLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVSQPDWTPPPEVTLVLTK 19 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 31729600.0 10323000.0 6818600.0 14588000.0 False True 9995302.015524507 9541302.53852926 10766965.169380803 1.0 0.9545787134505688 1.0772025850402283 23.252818729062128 -6.806404853858307 1.4294298206520264 0.9751379376625487 1.079178925590452 0.8502595672069229 0.01958742817592083 0.21175328282038408 0.853372294629727 0.010776364397043232 0.024972854254133245 1.561691139048973e-07 6.806404853858307 0.10404098792790328 EVSQPDWTPPPEVTLVLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVSQPDWTPPPEVTLVLTK 19 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 39741400.0 7499400.0 32242000.0 0.0 False True 11377138.079579113 26488163.192104217 0.0 1.0 2.3281921171061435 0.0 23.439634357386346 -6.754369997200873 1.6494916320805222 1.7790172460543945 6.256124433978941e-07 0.6572906049549758 0.5582641752669616 0.29470335887211035 1.5815897389729299 0.26795907693695137 0.6435643343184096 1.7604755701060366e-07 6.754369997200873 -1.779016620441951 EVSQPDWTPPPEVTLVLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVSQPDWTPPPEVTLVLTK 19 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 21871600.0 3893100.0 6439500.0 11539000.0 False True 5332484.277071629 6154981.597421157 8813725.853164697 1.0 1.1542428027188125 1.6528367258505667 22.34637637608332 -6.949761238184858 0.5614570987194138 0.9935281148806087 1.8374397600022148 0.9991824245031138 0.00796620404356682 0.08358172586158558 0.03635999541584409 0.008524366375121887 0.04145992859435716 1.1226354753043379e-07 6.949761238184858 0.8439116451216061 EVSQPDWTPPPEVTLVLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVSQPDWTPPPEVTLVLTK 19 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 22488000.0 10323000.0 6448700.0 5716300.0 False True 8584031.886440258 6413959.573133274 6911551.900815045 1.0 0.7471966155280791 0.8051638195488136 23.033224004496404 -10.850659594369837 7.2837764038135635 1.018286742378034 0.7761802175384463 0.9521025087723343 0.02366501194443479 0.006950069654528286 0.00014249819838963677 0.022661049343915347 0.0076378497623829636 1.4103938502239658e-11 10.850659594369837 -0.2421065248395876 EVSSATNALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVSSATNALR 10 0 P09012;M0QXK2;M0R221;M0R2B8;M0R0G9;M0QZG7 P09012 SNRPA U1 small nuclear ribonucleoprotein A 0 7403140.0 1918600.0 969440.0 4515100.0 False True 1857695.0931885417 1356542.4475628145 3332459.859903436 1.0 0.7302287940237003 1.7938680422434734 20.825082298363032 -6.83946041538306 1.2848350508004485 0.8564747911111085 1.8284944442764934 0.9235359402701523 0.12483786247743807 0.1694266598777936 0.5435235459919873 0.07619377352382038 0.17551732028451683 1.4472367582982802e-07 6.83946041538306 0.972019653165385 EVSSSFDHVIK(ub)ETTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVSSSFDHVIKETTR 15 1 Q9Y6C9;E9PIE4 Q9Y6C9 MTCH2 Mitochondrial carrier homolog 2 1 16007500.0 1058800.0 1998700.0 12950000.0 True False 1388097.053433785 1700501.7508715775 11610058.22517157 1.0 1.2250596935315048 8.364010424524247 20.404677011600995 -6.913617398752918 0.8707300611458817 0.8034394468961829 9.361740699348022 0.9922167039807926 0.3016886870445318 0.10207461262287763 0.12614867388624437 0.25150175615630227 0.7129644269791947 1.2200639677170424e-07 6.913617398752918 8.55830125245184 up EVSSSFDHVIK(ub)ETTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVSSSFDHVIKETTR 15 1 Q9Y6C9;E9PIE4 Q9Y6C9 MTCH2 Mitochondrial carrier homolog 2 1 20807700.0 1742800.0 2485900.0 16579000.0 True False 1687475.7679604893 3478532.8337972458 12236462.540661138 1.0 2.0613823912869913 7.251341188413227 20.686435354631797 -6.940303543087679 0.6567330140851771 0.9420346176842395 8.663496999861232 0.9982033966403567 0.1157711310490062 0.0876284087471816 0.05398097360494954 0.11295542958375922 0.4460952389877047 1.1473514185121615e-07 6.940303543087679 7.721462382176993 EVSSSFDHVIK(ub)ETTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVSSSFDHVIKETTR 15 1 Q9Y6C9;E9PIE4 Q9Y6C9 MTCH2 Mitochondrial carrier homolog 2 1 37742600.0 2571400.0 8138600.0 27032600.0 True False 3901001.7945208596 6686203.242827966 21689594.761190493 1.0 1.7139708195518015 5.560006353151272 21.895413231348723 -6.9381573702251025 0.6764872503063666 0.9551443512400426 6.543259491589597 0.997912476836047 0.09149984010182187 0.08861737074675222 0.05851340700476298 0.08787075797092632 0.33379712183377597 1.1530353701368927e-07 6.9381573702251025 5.588115140349554 EVSSSFDHVIK(ub)ETTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVSSSFDHVIKETTR 15 1 Q9Y6C9;E9PIE4 Q9Y6C9 MTCH2 Mitochondrial carrier homolog 2 1 18709300.0 1058800.0 1060500.0 16590000.0 True False 1450266.9729941282 1013643.6033954696 12671783.681775073 1.0 0.6989358664789601 8.737552407756842 20.467887073123887 -6.8981971203073735 0.9725809331721165 0.649050843579195 9.55115701183549 0.98564823606789 0.4457127410928138 0.1127450414111816 0.18499240936330777 0.34483891195493305 0.8893788401979457 1.2641624312497947e-07 6.8981971203073735 8.902106168256296 up EVSSSFDHVIK(ub)ETTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVSSSFDHVIKETTR 15 1 Q9Y6C9;E9PIE4 Q9Y6C9 MTCH2 Mitochondrial carrier homolog 2 1 39664900.0 2571400.0 23923500.0 13170000.0 True False 3328727.989871817 22592136.194553338 10773195.13561155 1.0 6.787017822812046 3.236430002208263 21.666539553441172 -9.40116709820916 9.861173585940485 0.9999999999606953 5.011723912510162 0.6299256420270947 1.4495214079033325 0.0 0.0 1.4034930786520108 0.467831022731724 3.9703875630069384e-10 9.40116709820916 4.011723912549466 EVSTYIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVSTYIK 7 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 218716000.0 19984000.0 108870000.0 89862000.0 False True 26199217.525331285 92627020.37193617 80563942.25717118 1.0 3.5354880458692217 3.0750514659178725 24.643020388600917 -10.617962870042831 8.588006111589356 0.9987927854802567 3.305269755893546 0.9709494721846426 0.1879724466321661 0.004344627250189734 0.00019327055923467847 0.1819949342197889 0.060667846279353524 2.4101114720839067e-11 10.617962870042831 2.3064769704132893 EVSTYIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVSTYIK 7 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 182353000.0 62374000.0 23263000.0 96716000.0 False True 60393971.511801444 32552037.21494235 71383178.18219313 1.0 0.5389948102449502 1.1819586689748383 25.84790121203852 -6.714253988380803 1.7798350412019885 0.7178184742925209 1.1806560396872947 0.4852764296825909 0.19414256339497568 0.3666387925320599 2.266508028412998 0.08671576310136225 0.21918684324224197 1.9308387745849228e-07 6.714253988380803 0.46283756539477383 EVSTYIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVSTYIK 7 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 604896000.0 10309000.0 578060000.0 16527000.0 False True 15639506.688852618 474900676.5966056 13260431.205958586 1.0 30.365451164460378 0.8478804012028227 23.898691671180956 -3.0502328178059153 19.046078386013054 9.999999999999998 12.024679251906942 0.0 13.898595783779838 0.0 0.0 4.436109139929653 0.0 0.0008907732818701488 3.0502328178059153 2.024679251906944 EVSTYIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVSTYIK 7 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 210275000.0 19984000.0 85701000.0 104590000.0 False True 27372624.847293787 81914446.44469137 79887996.09866501 1.0 2.9925681918221265 2.9185361851245037 24.706230450123808 -10.092787241904434 4.630366319392892 0.9998770111535639 2.9555521885219944 0.9989262703640024 0.03022344033698941 10511551.149877362 3.525409779098307 13805.107864706846 0.010346287499312108 8.076305864217156e-11 10.092787241904434 1.9556751773684304 EVSTYIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVSTYIK 7 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 76453800.0 62374000.0 9490300.0 4589500.0 False True 51866744.63671658 9439173.870222952 5549143.23054959 1.0 0.18198893985609693 0.10698846186350665 25.628306487472795 -13.947920118116583 0.3384158641795383 9.999999999946246 0.09490771783635465 0.9997303112730758 0.0066419990401721685 18.859669133881283 0.18630289776540915 121.13822958993839 0.02331754853503695 1.1274048061213021e-14 13.947920118116583 -9.90509228210989 EVSTYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVSTYIK 7 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 38827000.0 10309000.0 17740000.0 10778000.0 False True 13345203.720770253 16752753.405286714 8816514.591618944 1.0 1.2553389034603502 0.6606504311280814 23.669817993273405 -6.789998493214545 1.496124973197209 1.1427053858697618 0.65430547588676 0.8014105652837602 0.1085504675586166 0.23533759843479526 1.0406338485296742 0.05710657683080744 0.1337129563809768 1.6218157242416233e-07 6.789998493214545 -0.48839990998300176 EVSTYIK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVSTYIKK 8 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 112946000.0 39835000.0 43834000.0 29277000.0 True False 52224070.76268874 37294138.0635937 26247696.884814523 1.0 0.7141177912587836 0.5025976815190568 25.638211581461075 -7.481202617532214 0.14115714375417293 1.3185275417165598 4.678367338682456e-15 0.9999895675397568 0.0006582951194329851 0.1299032168279633 0.012058905353158204 0.03941087298576131 0.06607959793171055 3.3021544502265533e-08 7.481202617532214 -1.3185275417165552 EVSTYIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVSTYIKK 8 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 125635000.0 43952000.0 48458000.0 33225000.0 True False 42556767.81810849 67807532.10513169 24522375.7713653 1.0 1.593343093980898 0.576227402329429 25.34288524667985 -6.7485304900590295 1.6549423542195467 1.349491321769903 0.574384260049267 0.642817991832394 0.2493113737082566 0.3025867680596855 1.6300171500244136 0.11901994638910839 0.28943410893386895 1.784306715185273e-07 6.7485304900590295 -0.7751070617206359 EVSTYIK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVSTYIKK 8 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 326292000.0 73218000.0 48314000.0 204760000.0 True False 111077058.95279935 39691989.22099508 164289096.25050402 1.0 0.35733741598129315 1.4790551514360528 26.726985642859262 -6.751307534844923 1.6448251651276211 0.6227008997525664 1.4815339498717144 0.6546381833948751 0.2700719713195744 0.29777494819887523 1.5854086932351834 0.12968020292467058 0.31441979209593945 1.772933577419674e-07 6.751307534844923 0.858833050119148 EVSTYIK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVSTYIKK 8 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 107509000.0 39835000.0 34241000.0 33433000.0 True False 54563076.00039772 32728119.400154967 25536813.97424866 1.0 0.5998217439192103 0.4680237231138237 25.701421642983966 -13.999999999999998 0.15524419578514134 2.952321321936489 0.3314121337608512 0.9995496900125488 0.004800149354801253 11.981365741240218 0.12433535387623527 7.047611257306394 0.1238087721181533 1.0000000000000041e-14 13.999999999999998 -2.620909188175638 EVSTYIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVSTYIKK 8 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 142097000.0 43952000.0 71951000.0 26194000.0 True False 36548035.40374144 71563385.68184467 31671044.29262801 1.0 1.958063816325369 0.8665594181126854 25.123290522114125 -6.6748054375590735 1.919854308175009 1.6089505001052298 0.8708126659135305 0.300786751293474 0.4065134523860585 0.4501332971392688 3.2028916909616334 0.17017101883538263 0.4519044159352239 2.1144360878114758e-07 6.6748054375590735 -0.7381378341916993 EVSTYIK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVSTYIKK 8 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 234913000.0 73218000.0 43465000.0 118230000.0 True False 94782144.34255062 41046134.541194335 96713353.142244 1.0 0.4330576695210668 1.0203752385334712 26.49811196495171 -10.934909761082674 12.494403726363824 1.0420097174426777 0.7267164540272703 0.22401337751917405 0.239771393508706 0.13168210056865817 0.0006860035708068471 0.10895446058515425 0.07738588449634697 1.1616899679426864e-11 10.934909761082674 -0.3152932634154074 EVSTYIKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVSTYIKK 8 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 6393500.0 1244500.0 1281900.0 3867100.0 False True 1631551.551755145 1090645.516807063 3466969.5878425394 1.0 0.6684713796715763 2.124952523941361 20.637813141973997 -6.846865453792165 1.2501264412836384 0.8234525069388327 2.1797491670098643 0.9356206957628311 0.15815583346461337 0.16093637341935796 0.4855794627656146 0.09907098595715215 0.22884320288056884 1.4227694986655173e-07 6.846865453792165 1.3562966600710316 up EVSTYIKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVSTYIKK 8 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 8982800.0 1244500.0 6721500.0 1016800.0 False True 1704625.281347936 6424521.904971862 776652.7816533373 1.0 3.7688763479394476 0.45561496133578255 20.701023203496888 -6.684975716160668 1.8841653745276101 2.7440240736535455 0.4676835637445331 0.34702622120704796 1.1722628428091906 0.4275811494590007 2.9388955424834657 0.49845523142931036 1.3063423134129257 2.0654956460233057e-07 6.684975716160668 -2.276340509909012 EVSVPTFSWEEIQK(ub)HNLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVSVPTFSWEEIQKHNLR 18 1 O95864;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 96739600.0 36347000.0 45888100.0 14504500.0 True False 47651268.98484866 39041774.35041282 13003713.476988498 1.0 0.8193228676203075 0.27289333010466515 25.506011298782656 -6.951268706260229 0.544736000909996 1.0078036491487137 0.058972701578536804 0.9992971301124461 0.008194897179246602 0.0829802385060111 0.033884493918959604 0.008955954475790657 0.04528778474927452 1.1187454801702828e-07 6.951268706260229 -0.9488309475701768 down EVSVPTFSWEEIQK(ub)HNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVSVPTFSWEEIQKHNLR 18 1 O95864;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 140547000.0 56981000.0 27756000.0 55810000.0 True False 55172169.34482253 38839115.54562786 41191686.73588862 1.0 0.7039620882565968 0.7466026300043273 25.71743737191632 -10.22679973984876 4.653073195295147 1.0000693628508432 0.7252823591292233 0.9822517132314759 0.01740792827784437 1.2529303510367934e-05 2.081991267229021e-06 0.016859400271037765 0.005618384691982281 5.931987950030265e-11 10.22679973984876 -0.2747870037216199 EVSVPTFSWEEIQK(ub)HNLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVSVPTFSWEEIQKHNLR 18 1 O95864;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 252875600.0 32634600.0 57581000.0 162660000.0 True False 49509074.10883973 47305220.66759361 130510179.70358945 1.0 0.955485868380386 2.6360860519564264 25.561189633283863 -6.900815102943259 0.9560868404785166 0.9316809281033337 2.815451440802121 0.9869678754147746 0.08926743568171791 0.11080824305079758 0.17404948732238662 0.06991643530543323 0.18266870292850987 1.2565648212545045e-07 6.900815102943259 1.8837705126987871 up EVSVPTFSWEEIQK(ub)HNLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVSVPTFSWEEIQKHNLR 18 1 O95864;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 142255300.0 36347000.0 45466300.0 60442000.0 True False 49785468.14074193 43457448.52905182 46166844.44206432 1.0 0.8728942430791049 0.9273156639112466 25.569221360305548 -10.136815955674285 4.462402134207503 1.000011582296838 0.9001049535433778 0.8179331251069548 0.022217452076887075 3.1058710548000248e-06 6.008106687854286e-07 0.021514980455274803 0.007170651815534549 7.297667036057147e-11 10.136815955674285 -0.09990662875346024 EVSVPTFSWEEIQK(ub)HNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVSVPTFSWEEIQKHNLR 18 1 O95864;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 168535000.0 56981000.0 60236000.0 51318000.0 True False 47382226.18630759 59911496.71209013 62048356.532376945 1.0 1.264429756350351 1.309528097907471 25.497842647350595 -12.82982633836154 0.2663796981948878 5.766322753031378e-09 1.3257069290532044 0.9994958013918034 0.003065695097902705 8.00574945464944 0.15823550638108755 4.303217791358931 0.019076764485814503 1.479699958542622e-13 12.82982633836154 1.3257069232868817 EVSVPTFSWEEIQK(ub)HNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVSVPTFSWEEIQKHNLR 18 1 O95864;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 328365600.0 32634600.0 50658000.0 245073000.0 True False 42246133.02413892 47838837.76803913 200472228.66133115 1.0 1.1323838264842987 4.745339142562084 25.332315955376313 -6.914655594976826 0.8634331296281269 0.9039252076613309 5.261908295999292 0.9925629911924901 0.1496410732372085 0.10141913019792043 0.12266476200037695 0.1254065136035195 0.3584308593856261 1.2171508452665606e-07 6.914655594976826 4.357983088337961 up EVTAIETK(ub)LEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVTAIETKLEQK 12 1 Q14683;G8JLG1;V9GY57 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 1497200.0 0.0 0.0 1497200.0 True False 0.0 0.0 1810257.5977293502 0.0 EVTELIK(ub)VDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVTELIKVDK 10 1 A0A0B4J1Z5;P52657 A0A0B4J1Z5 GTF2A2 Transcription initiation factor IIA subunit 2 1 10550500.0 1129800.0 2260000.0 7160700.0 True False 1093935.117421254 3162429.785744308 5285097.853604683 1.0 2.890875094310109 4.831271772372849 20.061095742052014 -6.970801821228462 0.23825754777625816 0.28802803291021456 7.490121361936317 0.9999879788824481 0.005423149831262738 0.07604339028778637 0.008093397487051531 0.0469605030924466 0.1897611380322724 1.0695428253930802e-07 6.970801821228462 7.202093329026102 EVTELIK(ub)VDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVTELIKVDK 10 1 A0A0B4J1Z5;P52657 A0A0B4J1Z5 GTF2A2 Transcription initiation factor IIA subunit 2 1 35700600.0 2869600.0 15671000.0 17160000.0 True False 4353392.995861034 12874387.611918163 13768318.47850482 1.0 2.957322627237748 3.1626638099512214 22.053708832406045 -10.303528558261863 0.4790490387023623 1.3527295511012793e-20 3.160288479987786 0.9994203661689364 0.023466515041825807 1.652710324233108 0.22396502666054818 2.202810795736984 0.043363391608958184 4.971316823507123e-11 10.303528558261863 3.160288479987786 EVTELIK(ub)VDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVTELIKVDK 10 1 A0A0B4J1Z5;P52657 A0A0B4J1Z5 GTF2A2 Transcription initiation factor IIA subunit 2 1 8261400.0 1129800.0 1826900.0 5304700.0 True False 939478.7586263894 1817058.1270887412 6413888.243838425 1.0 1.9341130498207957 6.827071059292668 19.84150101748629 -6.938772975754935 0.6708809514627528 0.9437395712637338 8.10024575276457 0.9979987379665403 0.11431481489729196 0.08833088189933422 0.05719228688974057 0.11026846892811011 0.4234545026241794 1.1514021186418519e-07 6.938772975754935 7.156506181500836 EVTELIK(ub)VDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVTELIKVDK 10 1 A0A0B4J1Z5;P52657 A0A0B4J1Z5 GTF2A2 Transcription initiation factor IIA subunit 2 1 32707600.0 2869600.0 14431000.0 15407000.0 True False 3714753.768272602 13627902.16413148 12603084.089169879 1.0 3.6685882872039164 3.3927104931723213 21.824835154498494 -9.828016570976718 6.811912315135784 0.9999999737104213 3.53064939018822 0.9911656008925485 0.11262663779070499 4.46421171310746e-08 8.110670632438066e-09 0.1090502763754546 0.03635009104184065 1.4858789458835324e-10 9.828016570976718 2.5306494164777984 EVTWEVLEGEVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVTWEVLEGEVEK 13 0 P05455 P05455 SSB Lupus La protein 0 12510000.0 2428300.0 5569700.0 4512000.0 False True 3183524.81569065 4738722.470520555 4045141.5221601557 1.0 1.4885143810297305 1.2706486540399662 21.602193579449583 -10.116690756040729 4.508897065210844 0.9999605039815538 1.3795815175478772 0.8018763258031196 0.08894331063853089 62014543.62929385 2.187711563151939 25429.243581241695 0.030447660978345018 7.643798745810001e-11 10.116690756040729 0.3796210135663234 EVTWEVLEGEVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVTWEVLEGEVEK 13 0 P05455 P05455 SSB Lupus La protein 0 15483200.0 3723900.0 4075400.0 7683900.0 False True 3605686.832859802 5702728.472930245 5671256.077941125 1.0 1.5815928385569755 1.5728642948847127 21.781842668174292 -10.068199583599734 4.611465733879955 0.9999711752844557 1.5772285667417956 0.9998285348376745 0.0035634131052487417 563836.647012082 616649.1889187319 135.87465639619393 0.0012198510694766613 8.546738502253475e-11 10.068199583599734 0.5772573914573399 EVTWEVLEGEVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVTWEVLEGEVEK 13 0 P05455 P05455 SSB Lupus La protein 0 14699500.0 2428300.0 6930000.0 5341200.0 False True 3326108.132340047 6623809.685554568 4079718.5654669646 1.0 1.9914595142444929 1.2265742432723385 21.665403640972475 -10.167320901783524 4.735058110158008 0.999934533188698 1.609016878670507 0.4580792267848971 0.3122631042975447 0.0002290548790099656 4.027973848008414e-05 0.3023817641996903 0.10078248354506533 6.802665215178984e-11 10.167320901783524 0.6090823454818091 EVVEAHVDQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVVEAHVDQK 10 0 A0A096LPI6;P0DPI2;A0A0B4J2D5;A0A096LNH5;H7C1F6;H7C2G3;P0DPI2-2;A0A0B4J2D5-2 A0A096LPI6 C21orf33 0 11303870.0 1781370.0 4368700.0 5153800.0 False True 2335393.320811617 3716906.98905922 4620534.214740482 1.0 1.5915550309818847 1.9784822426120119 21.15523411463306 -8.45823297964509 0.1175458309232915 7.450681256441752e-11 2.991379077730075 0.9999616790576324 0.0024907893375061287 0.1358123269862644 0.02834698578360024 0.3528192830030806 0.32122437716460467 3.481504976962925e-09 8.45823297964509 2.9913790776555684 EVVEAHVDQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVVEAHVDQK 10 0 A0A096LPI6;P0DPI2;A0A0B4J2D5;A0A096LNH5;H7C1F6;H7C2G3;P0DPI2-2;A0A0B4J2D5-2 A0A096LPI6 C21orf33 0 7498250.0 2111300.0 1440730.0 3946220.0 False True 2044277.9371671928 2016021.0023076958 2912586.597937619 1.0 0.9861775474138055 1.4247507860764095 20.96315992573342 -6.899622522270255 0.9636459926941842 0.9815758472696637 1.4704358466041956 0.9863774152606117 0.023759333267070082 0.11168458931540602 0.17899001109604093 0.018504788509521045 0.048056045120620616 1.2600201134516604e-07 6.899622522270255 0.48885999933453184 EVVEAHVDQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVVEAHVDQK 10 0 A0A096LPI6;P0DPI2;A0A0B4J2D5;A0A096LNH5;H7C1F6;H7C2G3;P0DPI2-2;A0A0B4J2D5-2 A0A096LPI6 C21orf33 0 8370100.0 1781370.0 3111330.0 3477400.0 False True 2439990.6287141563 2973861.1528075705 2656109.739301059 1.0 1.2188002354643293 1.0885737461626213 21.218444176155952 -10.310752821951782 3.8479858888624707 0.9996590643146169 1.1536869908172978 0.6499837429135789 0.0531647417171379 28558595.68827724 47.05948037908918 86617.54128458191 0.019456303231596347 4.889305542544663e-11 10.310752821951782 0.15402792650268082 EVVEAHVDQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVVEAHVDQK 10 0 A0A096LPI6;P0DPI2;A0A0B4J2D5;A0A096LNH5;H7C1F6;H7C2G3;P0DPI2-2;A0A0B4J2D5-2 A0A096LPI6 C21orf33 0 3133870.0 2111300.0 558480.0 464090.0 False True 1755639.4964488377 555471.3573904 561129.073290285 1.0 0.31639260708930367 0.3196152025659541 20.743565201167698 -10.162734917358815 5.3733310631348985 1.0000216202229861 0.3180039082361729 0.9999832540355471 0.0013156190948684068 3.407771898942041e-07 5.309807914627405e-08 0.0012738830110465575 0.0004246142369364741 6.874879376580217e-11 10.162734917358815 -0.6820177119868132 EVVEEAENGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVVEEAENGR 10 0 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 81590800.0 2359800.0 42295000.0 36936000.0 False True 3093720.6523357057 35984750.864618696 33114217.03513023 1.0 11.631544961065192 10.703686840675019 21.560911503769663 -10.016553420660701 7.520132113156169 0.9999995911445994 11.167615900870105 0.9937929952548344 0.3787964914423042 2.597169778447271e-06 3.4302693775812056e-07 0.3667681257207482 0.12225604191315333 9.626016002869995e-11 10.016553420660701 10.167616309725506 EVVEEAENGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVVEEAENGR 10 0 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 75236900.0 21672000.0 8067900.0 45497000.0 False True 20984034.222653054 11289454.54354268 33579970.81925683 1.0 0.5380021031111019 1.6002628695203893 24.322788729806007 -6.788471869592508 1.5022288560410022 0.7412813447421457 1.6111260106453758 0.7964217603533283 0.19622034697294904 0.2376222396531363 1.0593535348175591 0.10281825260509823 0.24101450076917244 1.6275267314588224e-07 6.788471869592508 0.8698446659032301 EVVEEAENGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVVEEAENGR 10 0 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 77038800.0 2359800.0 35184000.0 39495000.0 False True 3232281.8311971505 33629454.542070925 30167094.42505759 1.0 10.404245761458084 9.333064380058872 21.624121565292555 -10.48953540374357 6.783103351021752 0.9969428014102917 9.868655070758479 0.9891770464112333 0.43730796773294756 0.020178849909059483 0.0015185595345744306 0.4225986119732196 0.14114053968279286 3.2394001372570097e-11 10.48953540374357 8.871712269348187 EVVEEAENGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVVEEAENGR 10 0 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 4946300.0 1692100.0 1646300.0 1607900.0 False True 2190456.806277555 1554681.9577859933 1315278.6984472144 1.0 0.7097523919807429 0.600458632499761 21.062800335693066 -13.999999999999998 0.135506695510124 2.381966611337201 0.45758967503441395 0.9996214390041017 0.0032803111410620177 11.932064628126925 0.11498286147623286 4.372594581171535 0.1273762933153773 1.0000000000000041e-14 13.999999999999998 -1.9243769363027872 EVVHTVSLHEIDVINSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVVHTVSLHEIDVINSR 17 0 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 0 10026600.0 2133000.0 3936300.0 3957300.0 False True 2921627.74215761 3762381.250396598 3022667.2431518007 1.0 1.287768868055071 1.0345832905185837 21.478340938856423 -9.625367065647971 6.195455687379042 0.9999999998216819 1.1611760792883954 0.35078998943217465 0.10336257920497864 7.74679029766266e-10 2.407109413249165e-10 0.1000803877136701 0.0333601289893377 2.3693702676405136e-10 9.625367065647971 0.16117607946671353 EVVIVSATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVVIVSATR 9 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 45578000.0 16295000.0 13107000.0 16176000.0 False True 21362902.801004466 11151486.690685844 14502262.691148642 1.0 0.5220024073770307 0.6788526272032075 24.348604358618886 -10.405606084083235 5.2156253442787275 1.0003172923488923 0.6004275172901059 0.8964037466207163 0.06403383410296414 0.00023643711199252903 2.69453579780858e-05 0.06204881575782248 0.02066683108954238 3.930012357020684e-11 10.405606084083235 -0.3998897750587864 EVVIVSATR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVVIVSATR 9 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 58441500.0 4267500.0 43942000.0 10232000.0 False True 6474109.496040202 36100206.77958697 8209640.7151550865 1.0 5.576088387393997 1.2680725774218675 22.626250335250983 -6.63196524713395 2.073285289571442 4.01053001209725 1.285569901906909 0.1245486615868372 1.9619400025552867 0.5539730819137085 4.540458901521831 0.7732730699624758 2.173211470709516 2.333644796406305e-07 6.63196524713395 -2.7249601101903407 EVVIVSATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVVIVSATR 9 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 41393000.0 16295000.0 12879000.0 12219000.0 False True 22319701.855817262 12309963.194842314 9333123.858204314 1.0 0.5515290156814494 0.41815629610535276 24.411814420141777 -13.999999999999938 0.16996433012757817 3.261440574412469 0.3004616168598626 0.9995137459519169 0.005488019572296584 12.091176437592194 0.13055132570454928 9.015079291878193 0.1087724938371986 1.0000000000001431e-14 13.999999999999938 -2.9609789575526064 EVVIVSATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVVIVSATR 9 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 23842000.0 4267500.0 13319000.0 6255500.0 False True 5524362.87500116 12577785.941658039 5117063.186850269 1.0 2.27678489379744 0.9262720973681865 22.397376657343433 -6.658785384008752 1.9766279346370859 1.8226268444646683 0.9318406919514833 0.23074975910136586 0.5437750173278292 0.48728723032562143 3.6584192178361206 0.22232951996430295 0.6029419555273675 2.193888825026413e-07 6.658785384008752 -0.8907861525131849 EVVK(ub)TDSAATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVVKTDSAATR 11 1 O75312;H7C0E5;H7BZM7 O75312 ZPR1 Zinc finger protein ZPR1 1 4074160.0 917560.0 1389400.0 1767200.0 True False 1202930.045663681 1182106.9358387806 1584347.0961793954 1.0 0.9826896751810601 1.3170733426192534 20.1981213168186 -6.894692869838952 0.9941766051261546 0.9840018210531769 1.3486269643485422 0.9837369252628494 0.019602446948648947 0.11541919623174986 0.20025215405323651 0.014922740198354207 0.03789060888151159 1.2744040124306445e-07 6.894692869838952 0.36462514329536533 EVVK(ub)TDSAATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVVKTDSAATR 11 1 O75312;H7C0E5;H7BZM7 O75312 ZPR1 Zinc finger protein ZPR1 1 7081300.0 1413300.0 2368500.0 3299500.0 True False 1368435.5651013071 3314254.4015643313 2435261.967121745 1.0 2.4219294543977834 1.7795956413493677 20.384096074105706 -10.619628540630144 5.976981302183689 0.9941356410610163 2.1007625478735754 0.7965683247778301 0.2622316810841505 0.020467580701544537 0.0013025429266217477 0.2535992219902096 0.08463491114057407 2.4008855588374844e-11 10.619628540630144 1.1066269068125592 EVVK(ub)TDSAATR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVVKTDSAATR 11 1 O75312;H7C0E5;H7BZM7 O75312 ZPR1 Zinc finger protein ZPR1 1 9637010.0 1248000.0 3400510.0 4988500.0 True False 1893307.2410212464 2793662.422194101 4002520.788462781 1.0 1.4755462619406687 2.114036592552104 20.85247711619813 -6.967033348960785 0.32124561625629666 0.9138272037829724 2.6963876659285595 0.999949133311319 0.003255239048493682 0.07727756755767905 0.012461861741558992 0.009629898600417441 0.05610156452913006 1.0788638743651524e-07 6.967033348960785 1.782560462145587 EVVK(ub)TDSAATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVVKTDSAATR 11 1 O75312;H7C0E5;H7BZM7 O75312 ZPR1 Zinc finger protein ZPR1 1 4722860.0 917560.0 1409700.0 2395600.0 True False 1256806.7281266472 1347414.7927454938 1829808.6189307012 1.0 1.072093872980696 1.4559188600606483 20.26133137834149 -6.938415100053709 0.6741480992624584 0.9955507888171224 1.5547699572935383 0.9979488438231291 0.009062730340701534 0.08849716905968749 0.05795871382683232 0.008719352351289376 0.033272337810474804 1.152351310217505e-07 6.938415100053709 0.5592191684764158 EVVK(ub)TDSAATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVVKTDSAATR 11 1 O75312;H7C0E5;H7BZM7 O75312 ZPR1 Zinc finger protein ZPR1 1 5204450.0 1413300.0 2128240.0 1662910.0 True False 1175221.5698058726 2116774.748697435 2010616.792572881 1.0 1.8011707775641759 1.7108406144255863 20.164501349539982 -10.155454039772565 4.596914397916771 0.9999020159076211 1.7560056960055133 0.989406209971677 0.03687713472273085 3.747151265437742e-05 6.884251138205443e-06 0.03571077323089117 0.011902044046808889 6.991107178711333e-11 10.155454039772565 0.7561036800978922 EVVK(ub)TDSAATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVVKTDSAATR 11 1 O75312;H7C0E5;H7BZM7 O75312 ZPR1 Zinc finger protein ZPR1 1 6717540.0 1248000.0 2773300.0 2696240.0 True False 1615560.6017578081 2618963.4170733704 2205551.9857586413 1.0 1.6210864601574286 1.3651929759607246 20.62360343829058 -10.10145590793304 4.57641081091748 0.9999706376665498 1.4931397179483765 0.8319826836006092 0.10446807763439608 12385525.443983076 27338422.34889998 2817.058328492416 0.035762199144323915 7.916698254061137e-11 10.10145590793304 0.4931690802818267 EVVNK(ub)DVLDVYIEHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVVNKDVLDVYIEHR 15 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 3775900.0 1692300.0 0.0 2083600.0 True False 2218621.6882565105 0.0 1868009.0593025074 1.0 0.0 0.8419682675916101 21.081232254431615 -9.726009572401747 11.050627164093973 0.9999683833767241 0.4209841298408093 0.3867147482483124 0.34373210635378026 0.0 0.0 0.3328171806472429 0.11093906021574762 1.879275394731208e-10 9.726009572401747 -0.5789842535359149 EVVNK(ub)DVLDVYIEHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVVNKDVLDVYIEHR 15 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 21244000.0 0.0 4195000.0 17049000.0 True False 0.0 5870085.376636008 12583355.44096335 0.0 EVVNK(ub)DVLDVYIEHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVVNKDVLDVYIEHR 15 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 6761700.0 1692300.0 0.0 5069400.0 True False 2317989.042687913 0.0 3872112.127570254 1.0 0.0 1.6704617909151969 21.144442315954507 -6.744595540251238 1.66997528154732 0.40817833328388403 1.6724315638783491 0.625308932144739 0.4201422698686652 0.309583444568885 1.6969039040843177 0.19889731691890541 0.48561625752868354 1.8005469893327773e-07 6.744595540251238 1.2642532305944651 EVVNK(ub)DVLDVYIEHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVVNKDVLDVYIEHR 15 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 14457800.0 0.0 7483700.0 6974100.0 True False 0.0 7443383.822701848 8432352.065404931 0.0 EVWALVQAGIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVWALVQAGIR 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 27293100.0 7456400.0 10460000.0 9376700.0 False True 11311903.93585804 8593331.27564698 7523391.135046391 1.0 0.7596715216442609 0.6650861939516393 23.43133843771674 -13.999999999999998 0.12883641666335946 2.1419845473122567 0.5306475048492535 0.9996509141819505 0.0026339909685933523 11.93866850496955 0.11150456078472508 3.4562018845810405 0.11951122806683907 1.0000000000000041e-14 13.999999999999998 -1.6113370424630031 EVWALVQAGIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVWALVQAGIR 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 3623070.0 1658000.0 743570.0 1221500.0 False True 1378700.4618539144 739564.2408229107 1476910.0024221228 1.0 0.5364212613872861 1.0712334138454902 20.394877618534018 -6.677481857161579 1.9108078226007321 0.7060270004638499 1.0691605195306144 0.3126315270433835 0.19658496675826412 0.4441519951815524 3.1331272886564236 0.08261852068804885 0.2186084126106425 2.1014455560033024e-07 6.677481857161579 0.3631335190667645 EVWALVQAGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVWALVQAGIR 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 20002200.0 7456400.0 6503500.0 6042300.0 False True 9652456.787617734 6141574.507964037 4942663.399233537 1.0 0.6362706037537003 0.5120627326272037 23.20246475980919 -13.999999999996401 0.14996906221180342 2.7586991891808488 0.37536080190636645 0.9995663426763056 0.004311596660516172 11.95758507038267 0.12196068572916512 6.128276039824513 0.12321137738139262 1.0000000000082868e-14 13.999999999996401 -2.3833383872744824 EVWFFGLQYQDTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVWFFGLQYQDTK 13 0 P26038;V9GZ54 P26038 MSN Moesin 0 2548780.0 651320.0 1489000.0 408460.0 False True 853886.8273918529 1266847.0040765395 366196.4774249863 1.0 1.483624016013983 0.42885832838470167 19.70368534477432 -6.782013694513074 1.5278497776648154 1.273117846911967 0.4199412538188671 0.7745282256017014 0.2047030026963855 0.24744646553012656 1.140998332083077 0.10550934562399251 0.2485603093107085 1.6519097080995991e-07 6.782013694513074 -0.8531765930930999 down EVWFFGLQYQDTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVWFFGLQYQDTK 13 0 P26038;V9GZ54 P26038 MSN Moesin 0 9549200.0 3527500.0 1331600.0 4690100.0 False True 3415521.443355877 1863314.8242022647 3461622.110015969 1.0 0.5455432955418628 1.0134974022047996 21.703674419088617 -10.938608602178485 11.433540254192367 1.0437973157710858 0.7795203488733516 0.2283859419725608 0.19104146406068814 0.1099107030510261 0.0005901550857067143 0.09532250589221875 0.06165836739517735 1.1518379885700927e-11 10.938608602178485 -0.26427696689773417 EVWFFGLQYQDTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVWFFGLQYQDTK 13 0 P26038;V9GZ54 P26038 MSN Moesin 0 83925000.0 23436000.0 23304000.0 37185000.0 False True 35554125.40110092 19145219.125016958 29835368.45123552 1.0 0.5384809472608806 0.8391534910407804 25.08351363194383 -10.188508693979648 7.125482338143387 1.00000051374616 0.6888172191508312 0.5881685596398984 0.12274905198756515 1.001759180380649e-06 1.1433228916344314e-07 0.11885145510275273 0.03961708617588234 6.478751255678751e-11 10.188508693979648 -0.3111832945953289 EVWFFGLQYQDTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVWFFGLQYQDTK 13 0 P26038;V9GZ54 P26038 MSN Moesin 0 8137100.0 3527500.0 2409500.0 2200100.0 False True 2933272.544746491 2396519.5452516987 2660130.7378869504 1.0 0.8170122307740819 0.9068815452049489 21.484079694522894 -10.087601975958282 4.501829578246757 1.0000107791804829 0.8619468879828838 0.7588245475971612 0.03668899400410196 43475123070.989555 8811227690.797558 5057224.898679839 0.012559682841632289 8.17331099266698e-11 10.087601975958282 -0.1380638911975991 EVWFFGLQYQDTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVWFFGLQYQDTK 13 0 P26038;V9GZ54 P26038 MSN Moesin 0 61183000.0 23436000.0 16023000.0 21724000.0 False True 30338363.992625 15131305.964651022 17770454.907063443 1.0 0.49875154666643573 0.5857420298399508 24.85463995403628 -10.81560833852765 7.287806015501031 1.0207405725208016 0.5422467882531934 0.9736284760092541 0.03551371604221298 0.011158813918212027 0.00028233317819132705 0.03206153149801982 0.011462002566119175 1.528944290419412e-11 10.81560833852765 -0.47849378426760825 EVWYFGLHYVDNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVWYFGLHYVDNK 13 0 P15311;E7EQR4 P15311 EZR Ezrin 0 25304400.0 9652900.0 11595900.0 4055600.0 False True 12655045.378816565 9865836.920464173 3635965.416062222 1.0 0.7795971191836829 0.28731350281434065 23.59320934492574 -6.957828799060307 0.4650261848743505 1.0136511899979719 0.03324645505439732 0.9996809951482079 0.00532117755921621 0.0804860699231102 0.024067775999135323 0.00674473094791278 0.04064719275577273 1.1019736271487314e-07 6.957828799060307 -0.9804047349435746 down EVWYFGLHYVDNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVWYFGLHYVDNK 13 0 P15311;E7EQR4 P15311 EZR Ezrin 0 75533000.0 23798000.0 21098000.0 30637000.0 False True 23042545.516366627 29522541.424616553 22612250.609701123 1.0 1.2812187526611296 0.9813260689293257 24.457796764715088 -6.660617037693622 1.970369227244788 1.180919657139399 0.9825657425954557 0.23839831970319236 0.11971781650977592 0.48296193078428346 3.6050154054480053 0.0490734781202057 0.13275021165545253 2.184655499147413e-07 6.660617037693622 -0.19835391454394324 EVWYFGLHYVDNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVWYFGLHYVDNK 13 0 P15311;E7EQR4 P15311 EZR Ezrin 0 544333000.0 139590000.0 160523000.0 244220000.0 False True 211768235.3959584 131876416.47807652 195949809.95457122 1.0 0.6227393651909015 0.9253031248439582 27.65791096470165 -9.902222401845373 6.3861422544693935 1.0000000220548295 0.7740212450174114 0.42653071164882583 0.12352113763474515 3.8784814884612517e-08 6.697608793913356e-09 0.11959883971607961 0.039866275746987194 1.2524996066683727e-10 9.902222401845373 -0.2259787770374181 EVWYFGLHYVDNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVWYFGLHYVDNK 13 0 P15311;E7EQR4 P15311 EZR Ezrin 0 37368700.0 9652900.0 10529600.0 17186200.0 False True 13221837.989813956 10064367.455269158 13127173.520899497 1.0 0.7611927678302141 0.992840294292867 23.65641940644863 -10.708092765734516 8.811477297996595 1.0003293917904719 0.8770165310801661 0.2731593572251494 0.09456970666856054 0.0006135612240690301 2.0326058026447428e-05 0.09180790258599525 0.03052224158192128 1.9584263070132434e-11 10.708092765734516 -0.12331286071030578 EVWYFGLHYVDNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVWYFGLHYVDNK 13 0 P15311;E7EQR4 P15311 EZR Ezrin 0 57840100.0 23798000.0 15187700.0 18854400.0 False True 19789091.43015651 15105880.845577573 22796767.86710413 1.0 0.763343830053652 1.1519865855167173 24.238202040149364 -6.7418923439731 1.6797169989651073 0.859498228801326 1.1523112809646099 0.6133948846604713 0.09942997513754286 0.31442064675916337 1.7425676907256575 0.04681448443961626 0.1146430457454494 1.8117891562321203e-07 6.7418923439731 0.2928130521632839 EVWYFGLHYVDNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVWYFGLHYVDNK 13 0 P15311;E7EQR4 P15311 EZR Ezrin 0 516584000.0 139590000.0 211650000.0 165344000.0 False True 180702006.73026657 199871491.44469747 135253088.57270753 1.0 1.1060834080445223 0.7484869206494175 27.4290372867941 -6.827222105712898 1.3401751343574047 1.0568043566495753 0.7393927944577917 0.9002115784257113 0.047370824916417885 0.1842734629537527 0.6482411173258169 0.027759531951432312 0.06389775804542053 1.4885995874207368e-07 6.827222105712898 -0.31741156219178357 EVYEEAGVK(ub)GK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVYEEAGVKGK 11 1 A0A024RBG1;Q9NZJ9;Q9NZJ9-2;F8VRL4;F8VRR0;A0A0C4DGJ4;Q9NZJ9-3;Q96G61;Q8NFP7 A0A024RBG1 NUDT4;NUDT11;NUDT10 Diphosphoinositol polyphosphate phosphohydrolase 2;Diphosphoinositol polyphosphate phosphohydrolase 3-beta;Diphosphoinositol polyphosphate phosphohydrolase 3-alpha 1 2013450.0 603790.0 608950.0 800710.0 True False 791574.5371106779 518097.03366850835 717860.2101526731 1.0 0.6545145269068553 0.9068763287572777 19.59436567983009 -10.351403141814068 5.317661312106961 1.0000779875934394 0.7806954278320847 0.5017193728744928 0.10302627418384316 9.529141566987852e-05 1.1622707674029934e-05 0.099790144722384 0.03325158701131457 4.452427517630174e-11 10.351403141814068 -0.21938255976135468 EVYEEAGVK(ub)GK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVYEEAGVKGK 11 1 A0A024RBG1;Q9NZJ9;Q9NZJ9-2;F8VRL4;F8VRR0;A0A0C4DGJ4;Q9NZJ9-3;Q96G61;Q8NFP7 A0A024RBG1 NUDT4;NUDT11;NUDT10 Diphosphoinositol polyphosphate phosphohydrolase 2;Diphosphoinositol polyphosphate phosphohydrolase 3-beta;Diphosphoinositol polyphosphate phosphohydrolase 3-alpha 1 1775970.0 394700.0 555270.0 826000.0 True False 382170.46454785665 776992.2066947976 609645.8205311595 1.0 2.0331037554512537 1.595219612934839 18.54385676060973 -10.138249931468945 4.620771673312681 0.9999179418804811 1.8141616842056845 0.8217268770472653 0.17876545265472102 125894884.27213031 75906439.86626187 122514.33471284035 0.06542145680306635 7.273610961397055e-11 10.138249931468945 0.8142437423252034 EVYEEAGVK(ub)GK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVYEEAGVKGK 11 1 A0A024RBG1;Q9NZJ9;Q9NZJ9-2;F8VRL4;F8VRR0;A0A0C4DGJ4;Q9NZJ9-3;Q96G61;Q8NFP7 A0A024RBG1 NUDT4;NUDT11;NUDT10 Diphosphoinositol polyphosphate phosphohydrolase 2;Diphosphoinositol polyphosphate phosphohydrolase 3-beta;Diphosphoinositol polyphosphate phosphohydrolase 3-alpha 1 11309300.0 1169700.0 3337400.0 6802200.0 True False 1774520.4165244824 2741814.894774782 5457742.188489833 1.0 1.5451019155613948 3.075615325508166 20.758997742567313 -6.952929226775478 0.5257020088045873 0.9750920879129306 3.7145956780572713 0.9994115683177157 0.021313264845775712 0.08233038453376135 0.031256079487731195 0.023931790792749163 0.12649858600216213 1.1144761353541123e-07 6.952929226775478 2.7395035901443405 EVYEEAGVK(ub)GK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVYEEAGVKGK 11 1 A0A024RBG1;Q9NZJ9;Q9NZJ9-2;F8VRL4;F8VRR0;A0A0C4DGJ4;Q9NZJ9-3;Q96G61;Q8NFP7 A0A024RBG1 NUDT4;NUDT11;NUDT10 Diphosphoinositol polyphosphate phosphohydrolase 2;Diphosphoinositol polyphosphate phosphohydrolase 3-beta;Diphosphoinositol polyphosphate phosphohydrolase 3-alpha 1 1748870.0 394700.0 671940.0 682230.0 True False 328210.53817475255 668320.1258503527 824881.1387248825 1.0 2.0362543188497866 2.5132682920914697 18.324262036044008 -9.649423559883587 0.2092439194707882 9.587113071285052e-17 2.9262175509686617 0.9993907262606534 0.015592422198282364 1.0860840763258564 0.08732660054237289 0.931980387407683 0.26383607612162235 2.2416945714369405e-10 9.649423559883587 2.9262175509686617 EVYEEAGVK(ub)GK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVYEEAGVKGK 11 1 A0A024RBG1;Q9NZJ9;Q9NZJ9-2;F8VRL4;F8VRR0;A0A0C4DGJ4;Q9NZJ9-3;Q96G61;Q8NFP7 A0A024RBG1 NUDT4;NUDT11;NUDT10 Diphosphoinositol polyphosphate phosphohydrolase 2;Diphosphoinositol polyphosphate phosphohydrolase 3-beta;Diphosphoinositol polyphosphate phosphohydrolase 3-alpha 1 13705700.0 1169700.0 2360000.0 10176000.0 True False 1514199.7082340624 2228663.925393269 8324072.414577319 1.0 1.4718427914587644 5.497341182481986 20.530124064659763 -6.928919328216046 0.7556102411384038 0.936265882415692 6.301462093440028 0.9963215287038821 0.12239657670021509 0.09320298710202467 0.08045789656711225 0.11080040949749492 0.36642701418694223 1.1778247384428657e-07 6.928919328216046 5.365196211024336 up EVYEGEVTELTPCETENPMGGYGK(ub)TISHVIIGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVYEGEVTELTPCETENPMGGYGKTISHVIIGLK 34 1 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 1 31813300.0 12851000.0 8121300.0 10841000.0 True False 16635872.831081415 7669342.515803538 8868049.238053532 1.0 0.4610123312240415 0.5330678665374882 23.98779422601622 -10.55368010446383 6.3459592126339635 1.0007399553407157 0.4970400988809965 0.9848401467132967 0.029416549110173135 0.00030837833439284853 2.1688587395444045e-05 0.028521007449640787 0.009494150400549429 2.7946015496174068e-11 10.55368010446383 -0.5036998564597193 EVYELLDSPGK(ub)VLLQSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVYELLDSPGKVLLQSK 17 1 P22234;E9PBS1;P22234-2 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 8594000.0 2618800.0 4240400.0 1734800.0 True False 2177648.2325108745 4217556.123546496 2097538.6591910752 1.0 1.9367481214739464 0.963212803553937 21.054339495739423 -6.65497083007162 1.9913624700451076 1.605463979575147 0.9673434685737873 0.2142889806984426 0.39933229375912943 0.49641796853333603 3.7789414961345855 0.16234200017136416 0.4423039638456715 2.2132433598531124e-07 6.65497083007162 -0.6381205110013598 EVYLHAIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EVYLHAIVR 9 0 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 0 22875200.0 6695900.0 8282300.0 7897000.0 False True 8778389.743187848 7046613.124152545 7079894.193372958 1.0 0.8027227464605128 0.8065139963587347 23.065524893757555 -10.276550805291244 5.648398406720905 1.0000160159863734 0.8046183714096455 0.9997176797359383 0.0015477712896814373 3.1219348636256693e-07 3.998484890141959e-08 0.0014987458937938826 0.0004995410357212402 5.289921102379338e-11 10.276550805291244 -0.1953976445767278 EVYLHAIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVYLHAIVR 9 0 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 0 22978800.0 7858400.0 3475400.0 11645000.0 False True 7608939.39347068 4863145.343971569 8594825.157488313 1.0 0.6391357707678275 1.1295694068563134 22.85926394047515 -6.70955680211191 1.79701790748733 0.7780453530822149 1.1283906111026076 0.4628984314901924 0.15207687912545587 0.3759628326446778 2.366432474992475 0.06735627816292515 0.17119368469451557 1.9518354334811505e-07 6.70955680211191 0.35034525802039274 EVYLHAIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVYLHAIVR 9 0 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 0 83621000.0 21016000.0 32378000.0 30227000.0 False True 31882808.475402698 26599892.92953135 24252620.201035287 1.0 0.8343020643884911 0.7606801709374494 24.926275382469516 -13.999999999999023 0.10989100838058433 1.7996620059743602 0.6254114228869467 0.9997436132098061 0.0016025313805197576 12.01323684694862 0.10057512216042552 2.131850992576918 0.12014950771232173 1.0000000000022497e-14 13.999999999999023 -1.1742505830874135 EVYLHAIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EVYLHAIVR 9 0 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 0 22658100.0 6695900.0 5357200.0 10605000.0 False True 9171555.17989365 5120501.190108639 8100317.416830899 1.0 0.5583023914345587 0.8831999871285545 23.128734955280446 -10.398426351994685 5.696097299029038 1.0001045608970813 0.7207511892815559 0.4962171581140262 0.1326388880178956 0.00017618988763341977 1.8607760713445198e-05 0.1284748951035669 0.04280901702939804 3.995523119638901e-11 10.398426351994685 -0.2793533716155254 EVYLHAIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EVYLHAIVR 9 0 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 0 14131700.0 7858400.0 2549500.0 3723800.0 False True 6534607.786147648 2535765.3374638744 4502429.363094142 1.0 0.388051650603928 0.6890129462151641 22.639669215909425 -10.522023127777612 6.379128072814315 1.0004121597957596 0.5385322984095887 0.75814620535027 0.12286693442907645 0.0007208344445044605 5.4010839453855034e-05 0.11906726941041745 0.03965513257028097 3.005916222277364e-11 10.522023127777612 -0.4618798613861709 EVYLHAIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVYLHAIVR 9 0 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 0 81619000.0 21016000.0 37459000.0 23144000.0 False True 27205626.287293382 35374373.72089256 18932029.47749385 1.0 1.300259488509348 0.6958865521995431 24.697401704561965 -6.771589288546544 1.5681191610690233 1.171865737449578 0.692259128068479 0.7367235684403843 0.1266013444497688 0.2638497187917213 1.2806173916558714 0.06362556821319415 0.15125103622201008 1.6920403345271007e-07 6.771589288546544 -0.479606609381099 EVYPHVSTIINICLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EVYPHVSTIINICLK 15 0 Q86VP6;Q86VP6-2;H0YH27;Q86VP6-3 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 125031000.0 17986000.0 66465000.0 40580000.0 False True 27286076.952730905 54603801.45658473 32559345.213154193 1.0 2.0011598424785557 1.193258571745526 24.70166165070025 -10.273192822153753 4.834470084458832 0.9998170219748137 1.5972092071127653 0.4214892916396077 0.32982431264283946 0.0006506737541863025 9.782092111191308e-05 0.3194475089481479 0.10645033916964672 5.3309815299786705e-11 10.273192822153753 0.5973921851379516 EVYPHVSTIINICLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EVYPHVSTIINICLK 15 0 Q86VP6;Q86VP6-2;H0YH27;Q86VP6-3 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 36956000.0 17986000.0 18970000.0 0.0 False True 23283231.557064075 17914302.824029807 0.0 1.0 0.7694079226126431 0.0 24.4727879727927 -7.300510064353781 0.8182668464828345 0.9889974958692576 1.5444553715759768e-18 0.9882809965671573 0.04628372659552496 0.10394948738114583 0.1374992060946144 0.03946672283705958 0.06985015940045933 5.005989514987861e-08 7.300510064353781 -0.9889974958692576 down EVYQQQQYGSGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EVYQQQQYGSGGR 13 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 10808400.0 3687500.0 1107100.0 6013800.0 False True 3570442.3309354526 1549170.8034502321 4438605.369867178 1.0 0.43388764188339396 1.2431527968984917 21.76767138562792 -6.718635866301754 1.7640617979807867 0.6550847124616584 1.241808605468341 0.5061229493645996 0.23826315869564144 0.3579862614648753 2.1763872522203074 0.10727062926479917 0.2697389028988776 1.911455244285316e-07 6.718635866301754 0.5867238930066826 EWAHATIIPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EWAHATIIPK 10 0 P30153;B3KQV6;E9PH38 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0 6741800.0 2310200.0 2948600.0 1483000.0 False True 3028694.572008622 2508680.3735527764 1329553.3859404959 1.0 0.8283041798727914 0.438985627084457 21.530264666550938 -6.957518082585694 0.4691085685414533 1.0103725586815047 0.24098111713498263 0.99966677312882 0.004284451950478529 0.08059996556284978 0.024499969321481966 0.005373990414843574 0.032134677914884446 1.1027623175184037e-07 6.957518082585694 -0.7693914415465221 down EWAHATIIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EWAHATIIPK 10 0 P30153;B3KQV6;E9PH38 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0 8387500.0 2310200.0 1368500.0 4708800.0 False True 3164343.3708075495 1308035.144975672 3596678.4207801293 1.0 0.4133670059459627 1.1366270974133401 21.59347472807383 -6.690931456430698 1.862909481789179 0.6325463411314264 1.1341701645019249 0.3748924802614336 0.24805672482934313 0.4146615324753532 2.7907455642821994 0.10648935369401172 0.2770006106352699 2.0373636041345317e-07 6.690931456430698 0.5016238233704985 EWAHATIIPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EWAHATIIPK 10 0 P30153;B3KQV6;E9PH38 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0 3595440.0 1505700.0 1149300.0 940440.0 False True 1252056.2638199264 1143108.4927818128 1137081.655896734 1.0 0.9129849239316751 0.9081713727684938 20.25586796363157 -13.999999999999998 0.4123506586900238 2.588407917749811 0.9079684262371198 0.9998544806814575 0.0005090274428097783 28.68553068773772 0.21318358911542656 40.94920429062949 0.0011914696041725019 1.0000000000000041e-14 13.999999999999998 -1.6804394915126912 EWEFQK(ub)YGH ddPTM_RPMI8226_Bortezomib_2h_R1 1 EWEFQKYGH 9 1 P62877 P62877 RBX1 E3 ubiquitin-protein ligase RBX1;E3 ubiquitin-protein ligase RBX1, N-terminally processed 1 37220600.0 10883500.0 15345100.0 10992000.0 True False 10538009.249826701 21472478.453639347 8112865.447068411 1.0 2.0376219022575315 0.7698669886062045 23.329099015373888 -6.689150133974344 1.8691751001696781 1.6510476243444605 0.7742681915471558 0.3664737523335254 0.4389190212711646 0.4185512793284892 2.834489580737846 0.1878870880453924 0.4898428457145003 2.0457373107523253e-07 6.689150133974344 -0.8767794327973047 EWEFQK(ub)YGH ddPTM_RPMI8226_Bortezomib_8h_R1 1 EWEFQKYGH 9 1 P62877 P62877 RBX1 E3 ubiquitin-protein ligase RBX1;E3 ubiquitin-protein ligase RBX1, N-terminally processed 1 50197800.0 15239700.0 15083000.0 19875100.0 True False 23119739.071307298 12391320.805983119 15946777.773434214 1.0 0.5359628310581299 0.6897473074523115 24.462621779928362 -10.387299261379665 5.277233220739577 1.0002262084816989 0.6128550692552094 0.8941808052036654 0.06278224958784481 0.00016718760164178209 1.941090735037991e-05 0.06082370537382995 0.020262883924257614 4.099215390448017e-11 10.387299261379665 -0.38737113922648947 EWEFQK(ub)YGH ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EWEFQKYGH 9 1 P62877 P62877 RBX1 E3 ubiquitin-protein ligase RBX1;E3 ubiquitin-protein ligase RBX1, N-terminally processed 1 35412500.0 10883500.0 15132100.0 9396900.0 True False 9050112.470800407 15050580.373813324 11361748.343643432 1.0 1.6630268874970373 1.255426203851208 23.109504290808164 -10.191756525186632 4.584575577672383 0.9999095217930504 1.4592265456789586 0.6285948502822303 0.1664022823070906 116882664.59479932 18.800724471416782 111644.74403076927 0.05696392727245008 6.430481228696753e-11 10.191756525186632 0.4593170238859082 EWEFQK(ub)YGH ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EWEFQKYGH 9 1 P62877 P62877 RBX1 E3 ubiquitin-protein ligase RBX1;E3 ubiquitin-protein ligase RBX1, N-terminally processed 1 41258400.0 15239700.0 7329800.0 18688900.0 True False 19728092.069397826 6921890.18658797 15287711.964307569 1.0 0.35086465342105694 0.7749209558901966 24.23374810202081 -10.133320061746693 5.656936392767173 1.0000054680776376 0.5628928046557886 0.5862068560725611 0.17312026054360566 1.1939112939147697e-05 1.8289141323088445e-06 0.16762506877258748 0.05587432383135059 7.356647352635676e-11 10.133320061746693 -0.43711266342184896 EWFLQAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EWFLQAAK 8 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6 P06744 GPI Glucose-6-phosphate isomerase 0 24891600.0 7756300.0 3151300.0 13984000.0 False True 7510080.502083972 4409630.523812402 10321170.888992414 1.0 0.5871615520750775 1.3743089552939403 22.84039694168887 -6.764180117818016 1.5965782735933447 0.7614512304207135 1.3778101722439806 0.7078519719908523 0.17376218754129913 0.2759528912571473 1.3872099883091897 0.0858316452784329 0.2054377230184412 1.7211546011286206e-07 6.764180117818016 0.6163589418232671 EWFLQAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EWFLQAAK 8 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6 P06744 GPI Glucose-6-phosphate isomerase 0 29550200.0 7326400.0 9130800.0 13093000.0 False True 10035168.068515472 8727371.064482188 10000703.058799338 1.0 0.8696786147372667 0.9965655772299155 23.258561443302035 -10.708132283851853 7.36691590658445 1.0004732795429767 0.9331220959841049 0.2702856202438978 0.05180138551977616 0.0004054921484412744 1.6065056214867345e-05 0.05050829981988199 0.016718825285713584 1.9582481104144604e-11 10.708132283851853 -0.06735118355887182 EWFLQAAK(ub)DPSAVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EWFLQAAKDPSAVAK 15 1 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6 P06744 GPI Glucose-6-phosphate isomerase 1 11052500.0 2758400.0 2968300.0 5325800.0 True False 2670836.1018718216 4153557.6694800123 3930813.2094247537 1.0 1.555152585577619 1.4717538102281504 21.348860015805727 -10.651534357563609 6.4376186208011985 0.9970676760073388 1.5134531979028845 0.9805969748946807 0.03404740746320027 0.0014383841387252741 7.785899824906483e-05 0.03309188453045572 0.01098875350720939 2.2308257171706113e-11 10.651534357563609 0.5163855218955457 EWHFHLPQLMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EWHFHLPQLMR 11 0 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 0 4601460.0 812060.0 1307000.0 2482400.0 False True 1064618.5240002272 1112000.6946460982 2225545.0608622287 1.0 1.0445062429196101 2.0904624620844507 20.021905143321632 -6.9158346577021215 0.8550569023154168 0.9732792532818759 2.2439640513417114 0.9929433051615931 0.04232854178047876 0.10068489054086147 0.11877514940682961 0.03568762674989126 0.10299058781635335 1.2138508933973973e-07 6.9158346577021215 1.2706847980598355 up EWHFHLPQLMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EWHFHLPQLMR 11 0 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 0 4623460.0 812060.0 1988600.0 1822800.0 False True 1112300.5270963477 1900737.0765791903 1392292.1817443997 1.0 1.7088341057798926 1.2517230261312275 20.085115204844524 -10.238863657960716 4.283141738198852 0.9997361006204903 1.4802785659705806 0.5954547457859087 0.18661481686915762 19612100.486184757 46882983.79361867 29359.925980634627 0.06388321801861749 5.7694756138929245e-11 10.238863657960716 0.48054246535009026 EWHHFLVVNMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 EWHHFLVVNMK 11 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 513464200.0 184812000.0 183889300.0 144762900.0 False True 242290321.72195366 156453733.23487723 129784223.77179044 1.0 0.6457283647277485 0.5356558316048942 27.852161536638427 -13.999999999999998 0.16367525049690881 2.75897214049384 0.43172014399647596 0.9995271872332948 0.004307822549360386 12.036235917717088 0.12796438117477615 6.720075942075216 0.09518465512532506 1.0000000000000041e-14 13.999999999999998 -2.327251996497364 EWHHFLVVNMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 EWHHFLVVNMK 11 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 661526300.0 228546000.0 163375300.0 269605000.0 False True 221290932.32975537 228611909.28093442 198987362.5233695 1.0 1.0330830408372529 0.899211551184798 27.721369095231434 -6.8413108101030655 1.2762048878956653 1.0175980459048888 0.8946905100721335 0.9266967090213643 0.015414918471035485 0.16727457596447878 0.5286355826607935 0.0094689037450942 0.021823872562595308 1.441083646798099e-07 6.8413108101030655 -0.12290753583275527 EWHHFLVVNMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 EWHHFLVVNMK 11 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 1433981000.0 256689000.0 551238000.0 626054000.0 False True 389415979.47957003 452865272.05784845 502314152.4907838 1.0 1.162934486312232 1.2899166417415513 28.536736844602743 -6.973916792247858 0.13505908882772968 0.817351123364334 1.6387992546074384 0.9999990780055664 0.00011379250820208278 0.07505099831584092 0.004072218727349516 0.007562632317800395 0.016921992258552232 1.0618989900485063e-07 6.973916792247858 0.8214481312431043 EWHHFLVVNMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EWHHFLVVNMK 11 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 772094000.0 184812000.0 275352000.0 311930000.0 False True 253141990.756508 263186038.1727014 238258558.4000059 1.0 1.0396775240100509 0.9412052014285605 27.915371598161318 -6.797369604289202 1.4669401750864803 1.0219655040666804 0.9399373255403172 0.8242655942272438 0.016958132203000652 0.22453942167017774 0.9542339738778737 0.009096169075613397 0.02118621055358622 1.5945215595129063e-07 6.797369604289202 -0.08202817852636324 EWHHFLVVNMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 EWHHFLVVNMK 11 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 488761400.0 228546000.0 125865000.0 134350400.0 False True 190046125.30450216 125186940.26275368 162442447.47393623 1.0 0.6587187192697163 0.8547527460171165 27.50177437066571 -10.192674593056616 5.319159470906405 1.0000123533781675 0.7567357326433548 0.6724753885232362 0.08003055629258904 1.1724912699147247e-05 1.7795803959034286e-06 0.07749318642352014 0.025829750975711562 6.4169020032428e-11 10.192674593056616 -0.2432766207348127 EWHHFLVVNMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 EWHHFLVVNMK 11 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 1558000000.0 256689000.0 851956000.0 449355000.0 False True 332288970.59664315 804543899.6704879 367577000.7716572 1.0 2.421217587288212 1.1061968145125385 28.307863166695192 -6.627732384020766 2.0883350828288405 1.9378395784850928 1.1114000027296784 0.1095165239328012 0.609971679418555 0.564925360645727 4.691843905917968 0.23911969055772275 0.6759523900171276 2.356500932647665e-07 6.627732384020766 -0.8264395757554144 EWLK(ub)DTCGANAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EWLKDTCGANAK 12 1 O75531 O75531 BANF1 Barrier-to-autointegration factor;Barrier-to-autointegration factor, N-terminally processed 1 7915200.0 3479700.0 2858900.0 1576600.0 True False 4561920.397462735 2432363.263904919 1413468.555815096 1.0 0.5331884495963058 0.3098406882770782 22.12120984210581 -10.719777063054234 0.14869670308661098 1.907860952142254 6.54184288721684e-17 0.9996830847252733 0.005118829967511508 2.682874643862885 0.0816081619800675 1.068216839834372 0.20659676430612883 1.906439101663826e-11 10.719777063054234 -1.907860952142254 EWLK(ub)DTCGANAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EWLKDTCGANAK 12 1 O75531 O75531 BANF1 Barrier-to-autointegration factor;Barrier-to-autointegration factor, N-terminally processed 1 23661900.0 7643000.0 7797100.0 8221800.0 True False 11594989.778145356 6405646.585979642 6596757.626257041 1.0 0.5524495241947716 0.5689317327981471 23.466998212351942 -9.921964530038041 7.0076887363922715 1.000000012252752 0.560690628510664 0.9989453867929659 0.0067288334854029705 1.291581510369844e-09 1.9395402115540671e-10 0.006515165201256206 0.0021717216690298065 1.1968382762162156e-10 9.921964530038041 -0.43930938374208794 EWLK(ub)DTCGANAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EWLKDTCGANAK 12 1 O75531 O75531 BANF1 Barrier-to-autointegration factor;Barrier-to-autointegration factor, N-terminally processed 1 8237200.0 3479700.0 2494300.0 2263200.0 True False 4766239.125356697 2384093.57845292 1728678.7720671091 1.0 0.5002043573033065 0.36269241357833426 22.1844199036287 -13.999999999999996 0.18107502311820967 3.6018236280073905 0.2546633392805406 0.9994968810781407 0.006142182424715223 12.21881330013269 0.13490470984900527 11.187865415640506 0.10174082199508938 1.0000000000000082e-14 13.999999999999996 -3.34716028872685 EWLK(ub)DTCGANAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EWLKDTCGANAK 12 1 O75531 O75531 BANF1 Barrier-to-autointegration factor;Barrier-to-autointegration factor, N-terminally processed 1 26740500.0 7643000.0 12122000.0 6975500.0 True False 9894014.16605364 11447400.043905616 5706030.5746741425 1.0 1.1570025928587855 0.576715423983476 23.238124534444392 -6.834650022194435 1.3069890765515624 1.0836603374548892 0.5595616180110705 0.9148639371960063 0.07150799541228085 0.1751393031757516 0.5834429010589487 0.04293531895170097 0.09881845708228107 1.463355950207199e-07 6.834650022194435 -0.5240987194438187 EWMPVTK(ub)LGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EWMPVTKLGR 10 1 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 16583800.0 4829900.0 7113600.0 4640300.0 True False 6332045.67281814 6052278.608595624 4160166.268900662 1.0 0.9558172700137831 0.6570019364767372 22.59424023094434 -6.933357214937055 0.7186997240139587 1.0040269141199012 0.5900599540778648 0.9971579064113032 0.008121889048919138 0.0909317739111301 0.06941230447796295 0.007553146446405138 0.02655621112473896 1.1658502899803664e-07 6.933357214937055 -0.41396696004203637 EWMPVTK(ub)LGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EWMPVTKLGR 10 1 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 19727100.0 4664200.0 7791400.0 7271500.0 True False 4516137.524054005 10902546.651614236 5366876.009675934 1.0 2.414130790646813 1.1883774533195008 22.106657988617062 -6.611439799552621 2.147713006359893 1.943827058500293 1.192742425641442 0.05509846687014375 0.6094441982740421 0.6086729186887657 5.322121451883131 0.2341192676705801 0.6767114610598457 2.4465843898860605e-07 6.611439799552621 -0.751084632858851 EWMPVTK(ub)LGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EWMPVTKLGR 10 1 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 36971400.0 7212000.0 8120400.0 21639000.0 True False 10941131.267824704 6671251.175025211 17362042.16528939 1.0 0.6097405297241788 1.5868598721913771 23.383258578768224 -6.798311441624232 1.4627179316856718 0.7842109348211491 1.5998049666285488 0.8271996424124031 0.16693790991459298 0.22317773665053814 0.9428535335237982 0.08979044584682884 0.2090452789241895 1.5910673302979246e-07 6.798311441624232 0.8155940318073996 EWMPVTK(ub)LGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EWMPVTKLGR 10 1 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 14255600.0 4829900.0 3633900.0 5791800.0 True False 6615644.553139732 3473342.2822996667 4423896.125865269 1.0 0.5250194828939602 0.6687022088823867 22.65745029246723 -10.770209746286753 10.48602415679978 1.0015698885747288 0.5968608458881787 0.9130161027006826 0.05865822725396281 0.0021581181280192446 4.7292840128030804e-05 0.056934959869191254 0.018931861439387333 1.697423668985606e-11 10.770209746286753 -0.40470904268655017 EWMPVTK(ub)LGR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 EWMPVTKLGR 10 1 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 21465300.0 6220100.0 8152600.0 7092600.0 True False 5172288.747151705 8108680.3256356055 8575629.867522838 1.0 1.5677160966894825 1.657995190667825 22.302371386323816 -11.534856677324901 0.31430939693310395 6.52901056732835e-13 1.6796527958778116 0.9994198947077582 0.00701472753528481 3.988053688185992 0.16614149595585193 2.7271370755591504 0.030689053305620596 2.918389960719884e-12 11.534856677324901 1.6796527958771588 EWMPVTK(ub)LGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 EWMPVTKLGR 10 1 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 40482900.0 10472800.0 8071900.0 21938200.0 True False 13557246.04975094 7622691.669229638 17945672.704941034 1.0 0.5622595947035772 1.3236960249217218 23.692560810688846 -6.750818577369021 1.6469051842016913 0.7428534862401203 1.3252948972472427 0.6524282760546557 0.18394921268359304 0.29863056867538057 1.5938886637292837 0.08822561838332528 0.2139966364704967 1.7749307874853644e-07 6.750818577369021 0.5824414110071224 EWQELDDAEK(ub)VQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EWQELDDAEKVQR 13 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 242964200.0 83316500.0 121798000.0 37849700.0 True False 109228738.33813375 103626213.16488543 33933376.1239595 1.0 0.9487083229332479 0.31066344480619834 26.70277724175989 -6.922882173869344 0.8030687754647753 1.012670129111807 0.20063091160851348 0.9949445943954085 0.022295026867338898 0.09650569296628375 0.09704585771774411 0.01950860503966495 0.060148933466477886 1.1943120829856815e-07 6.922882173869344 -0.8120392175032936 down EWQELDDAEK(ub)VQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EWQELDDAEKVQR 13 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 194365100.0 93747300.0 74365000.0 26252800.0 True False 90771343.27617763 104059332.30835202 19376404.11288187 1.0 1.146389692523827 0.2134638908441392 26.43573357143382 -6.8667818992661225 1.1509026371221234 1.081390405105015 0.1620490089069896 0.9613688455234254 0.08051863170202202 0.13998222396607923 0.3485499571609036 0.0543924334987838 0.12811180571929964 1.358995756797933e-07 6.8667818992661225 -0.9193413961980254 down EWQELDDAEK(ub)VQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EWQELDDAEKVQR 13 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 585280000.0 438454000.0 102040000.0 44786000.0 True False 665166773.2810338 83830164.7578412 35934027.46959891 1.0 0.1260287917635099 0.05402258337762272 29.309140863352585 -13.735003938471195 0.35619654445145804 9.999999999999817 0.044773886821920315 0.9997586678418923 0.006679557353358964 17.55989673357092 0.1920835836311742 118.95355600336644 0.02105013797157055 1.8407553081999112e-14 13.735003938471195 -9.955226113177897 EWQELDDAEK(ub)VQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EWQELDDAEKVQR 13 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 254802100.0 83316500.0 127395000.0 44090600.0 True False 114120861.5937527 121766267.66107127 33677308.35441053 1.0 1.0669939392372858 0.2951021214183869 26.76598730328278 -6.885767573514358 1.0470753993187494 1.0457795060577275 0.23396181653357276 0.9780489034375506 0.05173054074544015 0.12264522586290032 0.24243557564003254 0.03783685755849582 0.09300105819688853 1.3008655913079256e-07 6.885767573514358 -0.8118176895241548 down EWQELDDAEK(ub)VQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EWQELDDAEKVQR 13 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 226148400.0 93747300.0 116177000.0 16224100.0 True False 77955033.65956424 115551131.44167103 19616484.298237212 1.0 1.4822792835455874 0.2516384558809113 26.216138846868095 -6.800389835194138 1.4542182077674422 1.2659567223066306 0.23446047666128442 0.8333539302293477 0.20668593265051427 0.22018442114130785 0.9192222327400288 0.11180840585012627 0.2599754977882787 1.583471185147207e-07 6.800389835194138 -1.0314962456453463 down EWQELDDAEK(ub)VQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EWQELDDAEKVQR 13 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 589864600.0 438454000.0 110267000.0 41143600.0 True False 567587346.2204475 104130544.51751691 33655886.96898618 1.0 0.18346170895267497 0.05929640114970857 29.080267185445035 -13.999999999999998 0.26517512862183734 7.142242528879728 0.016115037624730967 0.9995730634145047 0.008621944725983977 14.652192505141684 0.16297836282886738 48.376600160874 0.05284310006155266 1.0000000000000041e-14 13.999999999999998 -7.126127491254997 EWQELDDAEK(ub)VQREPLLTLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EWQELDDAEKVQREPLLTLVK 21 2 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 42001800.0 23999800.0 12124700.0 5877300.0 True False 31068214.206784513 11449949.786532104 4807691.706190572 1.0 0.36854225705807464 0.15474631641817035 24.888935982302808 -11.332630320086647 0.2023510595235077 2.166982578951757 1.8387966523112382e-22 0.9993690187988638 0.009013845410518844 3.7450268585492044 0.11814359449550954 2.0821686892210147 0.13048046116476994 4.649108479991391e-12 11.332630320086647 -2.166982578951757 EWTDGLFTHVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EWTDGLFTHVLR 12 0 Q14204;A0A2R8YFZ7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 3690440.0 917240.0 1326300.0 1446900.0 False True 1202510.5225647958 1128421.209876908 1297188.6676448425 1.0 0.9383878050980667 1.0787337352176434 20.197618087673444 -6.78741472109825 1.5070119699745983 0.9654484508447331 1.0801143442287235 0.7927183139406541 0.02615045495175383 0.23923237829014904 1.073430693911475 0.01366160178258929 0.03204143141771969 1.6314932409345072e-07 6.78741472109825 0.11466589338399047 EWTDGLFTHVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EWTDGLFTHVLR 12 0 Q14204;A0A2R8YFZ7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 4986640.0 917240.0 1528600.0 2540800.0 False True 1256368.4154789713 1461061.3975957732 1940715.3694185717 1.0 1.1629243298342276 1.544702449940771 20.260828149196335 -6.956833535311653 0.47797425414734473 0.9906592530512602 1.7328304796457208 0.9996341357139605 0.004366411119818573 0.0808522476618468 0.02546253328572836 0.005361039057771947 0.03149594109509271 1.1045018933693274e-07 6.956833535311653 0.7421712265944606 EWTQK(ub)YAM ddPTM_RPMI8226_Bortezomib_1h_R1 1 EWTQKYAM 8 1 P61077;P61077-3;D6RAH7;H9KV45;A0A0A0MQU3;A0A087WY85;P62837-2;P62837;P51668;Q9Y2X8;A0A087WW00 P61077 UBE2D3;UBE2D2;UBE2D1;UBE2D4 Ubiquitin-conjugating enzyme E2 D3;Ubiquitin-conjugating enzyme E2 D2;Ubiquitin-conjugating enzyme E2 D1;Ubiquitin-conjugating enzyme E2 D4 1 77223000.0 30942000.0 33508000.0 12773000.0 True False 40565261.6427542 28508737.01316101 11451372.487267677 1.0 0.7027869625057199 0.2822950481157104 25.27374145791333 -7.126761585932489 0.3680383909301099 1.0371306580467252 8.203944476296785e-13 0.9998624851074305 0.003452786598317792 0.079147499893343 0.01827964266709462 0.007046399285586943 0.03729201075067344 7.468586478959746e-08 7.126761585932489 -1.0371306580459048 down EWTQK(ub)YAM ddPTM_RPMI8226_Bortezomib_2h_R1 2 EWTQKYAM 8 1 P61077;P61077-3;D6RAH7;H9KV45;A0A0A0MQU3;A0A087WY85;P62837-2;P62837;P51668;Q9Y2X8;A0A087WW00 P61077 UBE2D3;UBE2D2;UBE2D1;UBE2D4 Ubiquitin-conjugating enzyme E2 D3;Ubiquitin-conjugating enzyme E2 D2;Ubiquitin-conjugating enzyme E2 D1;Ubiquitin-conjugating enzyme E2 D4 1 175434900.0 78615000.0 77540000.0 19279900.0 True False 76119409.85667534 108502126.3657583 14229915.805397943 1.0 1.4254199627934074 0.18694201429295554 26.181761040850425 -6.813990463786796 1.397842533766185 1.2307796174162617 0.1632711138857023 0.8699553735438912 0.18528342390517985 0.20141055392191334 0.774879160348792 0.10420541004405132 0.24062570192630853 1.5346506802005196e-07 6.813990463786796 -1.0675085035305594 down EWTQK(ub)YAM ddPTM_RPMI8226_Bortezomib_8h_R1 2 EWTQKYAM 8 1 P61077;P61077-3;D6RAH7;H9KV45;A0A0A0MQU3;A0A087WY85;P62837-2;P62837;P51668;Q9Y2X8;A0A087WW00 P61077 UBE2D3;UBE2D2;UBE2D1;UBE2D4 Ubiquitin-conjugating enzyme E2 D3;Ubiquitin-conjugating enzyme E2 D2;Ubiquitin-conjugating enzyme E2 D1;Ubiquitin-conjugating enzyme E2 D4 1 208250000.0 96324000.0 62410000.0 49516000.0 True False 146130550.22766882 51272447.88844436 39729140.89636621 1.0 0.35086741142466643 0.2718742989365941 27.122682580323705 -13.999999999999998 0.2971022406500296 6.82364583065753 0.25184835210716605 0.9996433585097971 0.006160662032456869 16.402166947458017 0.17302602026963707 58.622478232120535 0.028908158753543765 1.0000000000000041e-14 13.999999999999998 -6.571797478550364 EWTQK(ub)YAM ddPTM_RPMI8226_Carfilzomib_1h_R1 2 EWTQKYAM 8 1 P61077;P61077-3;D6RAH7;H9KV45;A0A0A0MQU3;A0A087WY85;P62837-2;P62837;P51668;Q9Y2X8;A0A087WW00 P61077 UBE2D3;UBE2D2;UBE2D1;UBE2D4 Ubiquitin-conjugating enzyme E2 D3;Ubiquitin-conjugating enzyme E2 D2;Ubiquitin-conjugating enzyme E2 D1;Ubiquitin-conjugating enzyme E2 D4 1 102425100.0 43344000.0 45428200.0 13652900.0 True False 59369448.127557196 43421031.91303168 10428366.210301798 1.0 0.7313699770248863 0.17565206582173568 25.823217366717866 -7.189073567102197 0.5224438069784456 1.0081555175991306 4.744542557481656e-20 0.9989702431800466 0.01101560419657348 0.08618789842051669 0.040093837802624335 0.011911618335896327 0.04862209570933803 6.470330026246349e-08 7.189073567102197 -1.0081555175991306 down EWTQK(ub)YAM ddPTM_RPMI8226_Carfilzomib_2h_R1 2 EWTQKYAM 8 1 P61077;P61077-3;D6RAH7;H9KV45;A0A0A0MQU3;A0A087WY85;P62837-2;P62837;P51668;Q9Y2X8;A0A087WW00 P61077 UBE2D3;UBE2D2;UBE2D1;UBE2D4 Ubiquitin-conjugating enzyme E2 D3;Ubiquitin-conjugating enzyme E2 D2;Ubiquitin-conjugating enzyme E2 D1;Ubiquitin-conjugating enzyme E2 D4 1 209215500.0 78615000.0 113226000.0 17374500.0 True False 65371855.73500932 112616029.06439878 21007427.619388606 1.0 1.722698977995943 0.32135278069119066 25.9621663162847 -6.7665258062598665 1.5876928936188874 1.4163548843505558 0.3144733578458656 0.717123436561581 0.3043265290532054 0.2720817278373353 1.3529930687885992 0.1511332491127435 0.36092736025515826 1.711883451666935e-07 6.7665258062598665 -1.1018815265046902 EWTQK(ub)YAM ddPTM_RPMI8226_Carfilzomib_8h_R1 2 EWTQKYAM 8 1 P61077;P61077-3;D6RAH7;H9KV45;A0A0A0MQU3;A0A087WY85;P62837-2;P62837;P51668;Q9Y2X8;A0A087WW00 P61077 UBE2D3;UBE2D2;UBE2D1;UBE2D4 Ubiquitin-conjugating enzyme E2 D3;Ubiquitin-conjugating enzyme E2 D2;Ubiquitin-conjugating enzyme E2 D1;Ubiquitin-conjugating enzyme E2 D4 1 196131500.0 96324000.0 68884000.0 30923500.0 True False 124693316.82990324 65050544.846097514 25295740.301904645 1.0 0.5216842931111884 0.20286364133220622 26.893808902416154 -8.281883735734187 0.2823820225364396 1.1697852409021896 5.642448097414641e-14 0.9991448311917546 0.009579910129441625 0.09993640546792397 0.06661774933002503 0.0933745089802049 0.0990090858280219 5.225360575500755e-09 8.281883735734187 -1.1697852409021332 down EWYGWHFPELGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EWYGWHFPELGK 12 0 Q9Y2X3;H7BZ72 Q9Y2X3 NOP58 Nucleolar protein 58 0 3168010.0 779370.0 974540.0 1414100.0 False True 1021761.6174298159 829142.4307271668 1267782.4970050287 1.0 0.8114832428456533 1.240781093533406 19.962627216218934 -6.787328697929261 1.5068621014909527 0.8942716449324791 1.2450250546028805 0.7925981400830868 0.08001282221179584 0.2393537796532092 1.073684184937821 0.041800736970203076 0.09806490285898588 1.631816432052795e-07 6.787328697929261 0.35075340967040136 EWYGWHFPELGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EWYGWHFPELGK 12 0 Q9Y2X3;H7BZ72 Q9Y2X3 NOP58 Nucleolar protein 58 0 4833570.0 779370.0 1533100.0 2521100.0 False True 1067524.1506823138 1465362.5727162622 1925668.103684334 1.0 1.3726739313388534 1.803863736903313 20.025837277741825 -6.969212610412386 0.2763482112117041 0.9007318460643413 2.2888798999374096 0.9999755719163109 0.0016234240359474994 0.07655905484982663 0.009941268942447075 0.008135927820631913 0.03976357484359242 1.0734637656709973e-07 6.969212610412386 1.3881480538730684 EYADSFGK(ub)CPGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYADSFGKCPGGR 13 1 I3L1R7;Q99447;I3L1L9;Q99447-4;Q99447-2;I3L3V9 I3L1R7 PCYT2 Ethanolamine-phosphate cytidylyltransferase 1 14804600.0 2065900.0 2673700.0 10065000.0 True False 3134121.3375206687 2196557.345286554 8075648.3383537885 1.0 0.7008526820548052 2.5766865633677885 21.57962960416042 -6.866081160687024 1.1547107625408424 0.8342453704075053 2.678624459320065 0.9606083636190618 0.16331966485267413 0.14066301882281396 0.35301561320016006 0.11001358579173517 0.25881541950052056 1.3611902802887898e-07 6.866081160687024 1.84437908891256 up EYADSFGK(ub)CPGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYADSFGKCPGGR 13 1 I3L1R7;Q99447;I3L1L9;Q99447-4;Q99447-2;I3L3V9 I3L1R7 PCYT2 Ethanolamine-phosphate cytidylyltransferase 1 14682600.0 2065900.0 2516700.0 10100000.0 True False 2674348.2749771294 2376643.432642901 8261903.634751467 1.0 0.8886813489777151 3.08931477326831 21.35075592625287 -6.89499045034271 0.9924102921281331 0.8955068739113906 3.2981688991195055 0.9839038851845988 0.1284146351788643 0.11518784495267798 0.19895245135386086 0.09789032020747257 0.248855907674365 1.2735310842545537e-07 6.89499045034271 2.402662025208115 up EYAEDDNIYQQK(ub)IK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYAEDDNIYQQKIK 14 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 118781100.0 46031000.0 69206300.0 3543800.0 True False 60347086.76483811 58880989.8040446 3177121.5705299596 1.0 0.9757055884651628 0.052647472162337165 25.84678079125867 -6.98952943159749 0.9731151924021179 1.019344511997004 4.6142371039741847e-23 0.9908125226925942 0.042267710566445564 0.08720829002073492 0.14983230761169716 0.03458368906317753 0.07516085617166461 1.024402355483032e-07 6.98952943159749 -1.019344511997004 down EYAEDDNIYQQK(ub)IK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYAEDDNIYQQKIK 14 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 192955700.0 77648600.0 49357100.0 65950000.0 True False 75183687.69569466 69065647.42387615 48675716.54240913 1.0 0.9186254298062471 0.6474239031666508 26.163916344288033 -6.949066030547571 0.5690147575117858 1.0033934791480015 0.5494927588205627 0.9991258608948353 0.004456523389080833 0.08386316613451109 0.03753280733153166 0.004726734820193133 0.022590934121147727 1.1244340009510073e-07 6.949066030547571 -0.4539007203274388 EYAEDDNIYQQK(ub)IK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYAEDDNIYQQKIK 14 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 481681000.0 154199000.0 175841000.0 151641000.0 True False 233931156.45691928 144460799.6979963 121669089.88338852 1.0 0.6175355257759355 0.5201063925223448 27.801508780996336 -13.999999999999998 0.1920184694845562 3.064739231413069 0.4516117406757915 0.9994884240226606 0.004684531553414463 12.384310449289936 0.1389633255872071 9.573934774904599 0.06594354684585577 1.0000000000000041e-14 13.999999999999998 -2.6131274907372775 EYAEDDNIYQQK(ub)IK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYAEDDNIYQQKIK 14 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 152872300.0 46031000.0 47288600.0 59552700.0 True False 63049904.641001835 45199233.289511636 45487578.786355935 1.0 0.7168802799444399 0.7214535699198348 25.90999085278156 -10.24382841007048 5.955348812459693 1.0000088141871035 0.7191669249322128 0.9998011433984481 0.0018670378142554582 2.185053759557537e-07 2.774290145868184e-08 0.0018078082954594537 0.0006025838634451828 5.7038958892909144e-11 10.24382841007048 -0.28084188925489073 EYAEDDNIYQQK(ub)IK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYAEDDNIYQQKIK 14 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 195280400.0 77648600.0 74230200.0 43401600.0 True False 64568251.316230245 73830307.17905885 52476673.893674985 1.0 1.1434459765290321 0.8127318430332672 25.94432161972231 -6.788799819612165 1.5009601894065643 1.0802956491837172 0.809321305609767 0.7974810745579717 0.06093644908937116 0.23713435144603265 1.055396246264814 0.031956896967957456 0.07489014568226447 1.6262981965097889e-07 6.788799819612165 -0.2709743435739502 EYAEDDNIYQQK(ub)IK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYAEDDNIYQQKIK 14 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 452040000.0 154199000.0 153743000.0 144098000.0 True False 199613645.2167086 145187066.8990415 117873642.57033831 1.0 0.7273403916922643 0.5905089426244882 27.572635103088786 -13.999999999999998 0.08933269767428932 2.400245745831662 0.24410379034332572 0.999845528437013 0.002115498648929776 12.169757946138256 0.08667819190754862 3.243549482180308 0.31142743571249976 1.0000000000000041e-14 13.999999999999998 -2.1561419554883363 EYCELCK(ub)HR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYCELCKHR 9 1 O60337-5;O60337;D6RHY7 O60337-5 MARCH6 E3 ubiquitin-protein ligase MARCH6 1 9868880.0 769750.0 870530.0 8228600.0 True False 1009149.7042696025 740650.317299362 7377183.406304763 1.0 0.733935028832443 7.310296356519457 19.944708779037775 -6.897468995737265 0.9771088073206965 0.7072693510411607 7.966236070486903 0.985265124215002 0.36893919707813966 0.11329312000161139 0.1881034584985199 0.2844769411781241 0.7312112007743781 1.2662836642157147e-07 6.897468995737265 7.258966719445742 up EYCELCK(ub)HR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYCELCKHR 9 1 O60337-5;O60337;D6RHY7 O60337-5 MARCH6 E3 ubiquitin-protein ligase MARCH6 1 34397650.0 621650.0 16352000.0 17424000.0 True False 943088.4987026124 13433857.84124088 13980138.762789503 1.0 14.244535756423245 14.823782478549674 19.847033633087616 -9.662351436786942 0.846675071185193 4.903747946916843e-13 14.69368082428706 0.9997463315298634 0.10168487968468813 0.9967304552725321 0.44979932280246177 3.3586378189545645 0.08100725141929589 2.1759482538807321e-10 9.662351436786942 14.69368082428657 EYCELCK(ub)HR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYCELCKHR 9 1 O60337-5;O60337;D6RHY7 O60337-5 MARCH6 E3 ubiquitin-protein ligase MARCH6 1 9719450.0 769750.0 1332900.0 7616800.0 True False 1054347.376711588 1274008.070689132 5817868.712920089 1.0 1.208338066589254 5.517980924906822 20.007918840560666 -6.916968743382333 0.8469078897334293 0.8941315497011915 6.166694516110745 0.9932965822962634 0.17049759206866652 0.09998818720202043 0.11509994228598916 0.14459032220183943 0.4213217904125145 1.2106852646706806e-07 6.916968743382333 5.272562966409554 up EYCELCK(ub)HR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYCELCKHR 9 1 O60337-5;O60337;D6RHY7 O60337-5 MARCH6 E3 ubiquitin-protein ligase MARCH6 1 19967150.0 621650.0 7336500.0 12009000.0 True False 804738.1795534804 6928217.32569819 9823485.222745575 1.0 8.609281256597523 12.20705749066891 19.618159955180065 -8.612832215801646 0.41820831565251165 2.9791391973337833e-15 12.873523413274489 0.9965719721012188 0.2735391679261881 0.24645589717650782 0.13812092300872475 1.2767805938825998 0.8611904300277833 2.438752817800399e-09 8.612832215801646 12.873523413274485 EYDALK(ub)AAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYDALKAAK 9 1 Q96AG4 Q96AG4 LRRC59 Leucine-rich repeat-containing protein 59 1 4899900.0 1265700.0 1576200.0 2058000.0 True False 1225521.0463091512 2205584.879774412 1518948.061323397 1.0 1.7997119563281894 1.2394304168810053 20.224963829657135 -10.231901226187848 5.372677499395509 0.9999611964642856 1.5195711866046435 0.5341494811709193 0.2287339806579908 0.00010632934971550671 1.5201286484628877e-05 0.22148721412202615 0.07382357481664605 5.862714880711038e-11 10.231901226187848 0.5196099901403579 EYDQALADLK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYDQALADLKK 11 1 Q08752;H0Y8J0 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 16305900.0 6312600.0 5883700.0 4109600.0 True False 8275879.731305356 5005874.894482971 3684378.014066801 1.0 0.6048752588256129 0.44519472656542136 22.98048124880072 -13.999999999962876 0.12478897282704522 2.878549775234896 0.2060360354535632 0.9996698041161819 0.004237498984560811 11.947946312849083 0.10930531989745604 5.533990675555413 0.21236767831205755 1.0000000000854813e-14 13.999999999962876 -2.6725137397813326 EYDQALADLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYDQALADLKK 11 1 Q08752;H0Y8J0 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 17502400.0 7976700.0 3178000.0 6347700.0 True False 7723484.024724821 4446991.973051059 4685046.943081891 1.0 0.575775383080371 0.606597609069155 22.880820356109474 -9.93653550310323 5.38184655711043 1.000000772898539 0.5911864960729633 0.9957548667409233 0.012583121074526067 1.1668732729229193e-07 2.3057009148343446e-08 0.012183577553327772 0.004061184862832834 1.1573494161644195e-10 9.93653550310323 -0.4088142768255757 EYDQALADLK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYDQALADLKK 11 1 Q08752;H0Y8J0 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 27524100.0 5736700.0 5590400.0 16197000.0 True False 8702993.3089476 4592749.4420054415 12995655.8506027 1.0 0.527720667931987 1.4932397842064047 23.053080256406034 -6.773688492073919 1.5602368492789347 0.7303924761132847 1.4994570180759368 0.744502160028796 0.19925672027227828 0.26050669768544177 1.2519977079192754 0.1006317615939109 0.23875376004233356 1.6838814315509584e-07 6.773688492073919 0.7690645419626521 EYDQALADLK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYDQALADLKK 11 1 Q08752;H0Y8J0 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 14644100.0 6312600.0 3962000.0 4369500.0 True False 8646538.811600616 3786945.7394180656 3337514.09267728 1.0 0.4379724444580432 0.3859942302230239 23.043691310323613 -13.999999999999998 0.3368392344182898 7.376541320078921 0.377509965251242 0.999728855691014 0.004577750569271819 19.41754287528698 0.18597789674568377 88.02356829108594 0.016242849721035565 1.0000000000000041e-14 13.999999999999998 -6.999031354827679 EYDQALADLK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYDQALADLKK 11 1 Q08752;H0Y8J0 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 19971100.0 7976700.0 8012300.0 3982100.0 True False 6632979.477726242 7969136.149582977 4814738.698849881 1.0 1.2014413999536095 0.7258787269006226 22.66122563154375 -6.791623275710056 1.4897900411711753 1.1123508952133248 0.7205898016248793 0.8065331712630852 0.08572736244897962 0.23295401914786087 1.021369591935724 0.04528834351225375 0.10590944131813314 1.6157595231229824e-07 6.791623275710056 -0.39176109358844546 EYDQALADLK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYDQALADLKK 11 1 Q08752;H0Y8J0 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 39494500.0 5736700.0 9328800.0 24429000.0 True False 7426271.23726285 8809644.079325743 19983172.662707258 1.0 1.1862809474452716 2.6908756796328097 22.824206578498483 -6.929918043517677 0.7474671301456375 0.9770503515833294 2.999115042958891 0.9965220952826424 0.04464368119338679 0.0926803061855221 0.07788939911549633 0.040652791905079304 0.13620115602503502 1.1751192928635638e-07 6.929918043517677 2.0220646913755616 up EYEAAVEQLK(ub)SEQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYEAAVEQLKSEQIR 15 1 Q9NVI7-2;H0Y2W2;Q9NVI7-3;Q5T9A4 Q9NVI7-2 ATAD3A;ATAD3B ATPase family AAA domain-containing protein 3A;ATPase family AAA domain-containing protein 3B 1 5595100.0 1760400.0 1652400.0 2182300.0 True False 2307901.447737853 1405868.3610047519 1956496.5300997612 1.0 0.6091544170496312 0.8477383347618547 21.138150188500145 -10.339500779266054 5.840846676655165 1.000037668725367 0.7284463759057423 0.6333369127785214 0.09740147653818859 4.778417078665599e-05 5.4034468632376885e-06 0.09432163163714498 0.031436191377367716 4.57613913776871e-11 10.339500779266054 -0.2715912928196246 EYEAAVEQLK(ub)SEQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYEAAVEQLKSEQIR 15 1 Q9NVI7-2;H0Y2W2;Q9NVI7-3;Q5T9A4 Q9NVI7-2 ATAD3A;ATAD3B ATPase family AAA domain-containing protein 3A;ATPase family AAA domain-containing protein 3B 1 4602400.0 1867900.0 1859700.0 874800.0 True False 1553241.6120005604 1849681.4269784505 1057716.6353818031 1.0 1.1908523520665135 0.6809736664339517 20.566850832612047 -6.805322686910951 1.4340731920313075 1.1046017582346623 0.6729739781306042 0.8472726072081106 0.08220083388995598 0.2132467935419873 0.8651748675876267 0.04508208438812296 0.10452377213712416 1.565587384388493e-07 6.805322686910951 -0.4316277801040581 EYERPK(ub)PSNGVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYERPKPSNGVLR 13 2 Q9UIG8-4;Q9UIG8-3;Q9UIG8-2;Q9UIG8 Q9UIG8-4 SLCO3A1 Solute carrier organic anion transporter family member 3A1 1 12884100.0 2134000.0 3782000.0 6968100.0 True False 2762505.0674288194 3571528.375354805 5699977.298743728 1.0 1.2928585787822564 2.063336413731519 21.397545680252758 -6.954359200367626 0.5087443022924688 0.9856722794450723 2.404252317108272 0.9995004496488162 0.010023467363626862 0.08178115095925328 0.029073159145310664 0.01157025354861342 0.0635841985745558 1.110812605891272e-07 6.954359200367626 1.4185800376631998 up EYFGGFGEVESIELPMDNK ddPTM_RPMI8226_Bortezomib_2h_R1 2 EYFGGFGEVESIELPMDNK 19 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 33590500.0 13219900.0 3241500.0 17129100.0 False True 12800241.510707414 4535847.854199185 12642474.848014867 1.0 0.3543564276037248 0.9876747120309742 23.609667694984694 -10.817237583261807 9.498270116865266 1.0060429436211424 0.6710155698173524 0.2645906617931455 0.2585511069369311 0.033115492215498456 0.0006371955974210182 0.25056576451886176 0.08344701094251891 1.523219240096294e-11 10.817237583261807 -0.33502737380379 EYFGGFGEVESIELPMDNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYFGGFGEVESIELPMDNK 19 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 8066800.0 8066800.0 0.0 0.0 False True 6707901.619833025 0.0 0.0 1.0 0.0 0.0 22.67743009936838 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 EYFGGFGEVESIELPMDNK(ub)TNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYFGGFGEVESIELPMDNKTNK 22 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 15490600.0 8299000.0 3752300.0 3439300.0 True False 8035552.787642924 5250612.957985995 2538444.1532116425 1.0 0.65342274473766 0.31590162124443544 22.93796584357417 -7.386840911061288 0.2771825104850449 1.0991418985082069 1.8996138043560487e-11 0.9998614226618209 0.003287767199271743 0.11573607867682988 0.0226669161018092 0.018357924408647516 0.055806542285195236 4.103543947638893e-08 7.386840911061288 -1.0991418984892107 down EYFSWEGAFQHVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYFSWEGAFQHVGK 14 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 97208000.0 26230000.0 35960000.0 35018000.0 False True 34387784.01168136 30594908.17098213 31394673.27637514 1.0 0.8897028130858676 0.9129600577260379 25.035392814145307 -10.15236336280304 5.168028709567079 1.0000041074126274 0.9013314354058665 0.9599972087212038 0.009494730365552503 4.493674666428526e-07 7.369608671665355e-08 0.009193615887827385 0.0030644110484992952 7.041037173397888e-11 10.15236336280304 -0.09867267200676089 EYFSWEGAFQHVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYFSWEGAFQHVGK 14 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 98062000.0 30220000.0 13529000.0 54313000.0 False True 29260682.64159168 18931200.25280295 40086795.944925934 1.0 0.6469842308427142 1.3699884051216842 24.802460091656183 -6.773952545320929 1.5594106058731876 0.7985392307900834 1.3746668808851206 0.7453922798056238 0.14895011690296744 0.26009997450378464 1.2487800877008568 0.07526604639795825 0.17851645413015804 1.6828579342800495e-07 6.773952545320929 0.5761276500950372 EYFSWEGAFQHVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYFSWEGAFQHVGK 14 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 172987000.0 17435000.0 112590000.0 42962000.0 False True 26450169.66923516 92497434.83031476 34470541.86908649 1.0 3.4970450468565724 1.303225737307085 24.65677364099995 -6.614879791643334 2.1352194712649486 2.6627118157443608 1.311267427930331 0.0660127733059821 1.0752074303925017 0.5992534673326946 5.183988703070534 0.41476558489704346 1.1931673923404165 2.4272818493812444e-07 6.614879791643334 -1.3514443878140299 EYFSWEGAFQHVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYFSWEGAFQHVGK 14 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 102239000.0 26230000.0 30792000.0 45217000.0 False True 35927939.83909712 29431507.62447275 34537675.87334676 1.0 0.8191816106428987 0.9613041000408974 25.0986028756682 -9.920712603547898 5.011578612777714 1.000000428054616 0.8902428553589365 0.4429603365524136 0.05802126334380755 2.7753472416104813e-07 5.980049812834313e-08 0.056179065987013686 0.018726282219855415 1.2002933402544595e-10 9.920712603547898 -0.10975757269567943 EYFSWEGAFQHVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYFSWEGAFQHVGK 14 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 59358000.0 30220000.0 11999000.0 17139000.0 False True 25129268.972994756 11934359.005384965 20722685.65821759 1.0 0.47491867026495116 0.8246433941427936 24.58286536709046 -10.230300682003383 5.547337295417492 1.000018817326946 0.6497810322038604 0.5721201400982208 0.1427745206561364 3.3229186689980366e-05 4.61031157564441e-06 0.1382482555078007 0.04608027839698809 5.884361129622468e-11 10.230300682003383 -0.35023778512308557 EYFSWEGAFQHVGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYFSWEGAFQHVGK 14 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 115270000.0 17435000.0 60955000.0 36880000.0 False True 22569951.19523031 57562800.6662487 30168218.420755826 1.0 2.550417595870274 1.3366541274192587 24.4278999630924 -6.584699632015659 2.2495838637319734 2.0528191275864884 1.3399588462964351 0.0 0.6727573651928354 0.6851935050792046 6.52933612280073 0.2504597863559481 0.7507068688580429 2.60195851494137e-07 6.584699632015659 -0.7128602812900533 EYGFCIMDNHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYGFCIMDNHK 11 0 P11387 P11387 TOP1 DNA topoisomerase 1 0 6795000.0 1210700.0 1692300.0 3892000.0 False True 1587239.4244354786 1439815.4365337328 3489293.174700211 1.0 0.9071192501697222 2.1983407928146828 20.59808833479566 -6.889614719826832 1.0246791175667467 0.9299787683857701 2.3085549565505374 0.980649826899928 0.08179636927764122 0.11945550407155575 0.22368794087832322 0.060854984228318976 0.15150075607478536 1.2893929169820633e-07 6.889614719826832 1.3785761881647673 up EYGFCIMDNHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYGFCIMDNHK 11 0 P11387 P11387 TOP1 DNA topoisomerase 1 0 4605900.0 1210700.0 1375600.0 2019600.0 False True 1658328.5079372802 1314821.4434991137 1542612.0749676244 1.0 0.7928594589105632 0.9302210434085884 20.66129839631855 -10.156821593141123 5.6618962054693105 1.0000023298830312 0.8615402512057657 0.5753242554544417 0.05607763204676096 1.6492860376512678e-06 2.455826421654442e-07 0.054297847580026815 0.01809897791764933 6.9691274496195e-11 10.156821593141123 -0.13846207867726545 EYGGLDVLVNNAGIAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYGGLDVLVNNAGIAFK 17 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 9492300.0 4323000.0 1691600.0 3477700.0 False True 4185768.7312905593 2367064.701577464 2566786.041236334 1.0 0.5655029824946035 0.6132173576739728 21.997061172499894 -10.6060519510749 9.997167181448667 1.000047325647505 0.5893601703492275 0.9899755144507184 0.019479312097528883 2.054938818965256e-05 8.097748988715814e-07 0.018862913915940645 0.0062869209457754975 2.4771257217446216e-11 10.6060519510749 -0.4106871552982776 EYGGLDVLVNNAGIAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYGGLDVLVNNAGIAFK 17 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 7996430.0 4323000.0 897630.0 2775800.0 False True 3594766.041371814 892794.2890243955 3356206.946150904 1.0 0.24835949787811296 0.9336371011422283 21.77746644793417 -10.875155472136983 10.316813157965834 1.0210730523434306 0.5909982995102869 0.3220149349680339 0.27976341002574845 0.11402813475318864 0.0013798606744126831 0.2277836608043648 0.09029325232566 1.3330441331649543e-11 10.875155472136983 -0.43007475283314367 EYGGLNVLVNNAAVAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYGGLNVLVNNAAVAFK 17 0 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 0 2345350.0 594180.0 1056300.0 694870.0 False True 778975.7340473046 898704.1574251519 622971.5180637032 1.0 1.1536998113609744 0.7997316101580543 19.571218861883082 -6.788672222100877 1.501487911486018 1.0860498711323092 0.7960953286332413 0.7970543092386541 0.06528715809831 0.23732709701625648 1.0570013161378637 0.03422687713071375 0.08021671685101979 1.626776079830905e-07 6.788672222100877 -0.28995454249906794 EYGGLNVLVNNAAVAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYGGLNVLVNNAAVAFK 17 0 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 0 7517400.0 3240500.0 1254500.0 3022400.0 False True 3137632.1012600176 1755428.3921310755 2230742.7699435567 1.0 0.5594755329747316 0.7109637771259829 21.58124477032247 -10.424539252804518 7.14667702022648 1.0000281448754855 0.6352196550503573 0.8854674634419716 0.06184481670012063 2.7735883383628957e-05 2.233308015810989e-06 0.059885593463027964 0.0199603287607348 3.762363453905053e-11 10.424539252804518 -0.36480848982512826 EYGMIYLGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 EYGMIYLGK 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 90387600.0 23430800.0 25665300.0 41291500.0 False True 30718005.70418996 21836137.282555856 37019051.67603641 1.0 0.7108579083171858 1.2051254899984274 24.872581219656357 -6.748141041488896 1.656671752253228 0.8296032113325541 1.205973448239879 0.640958023663839 0.12148999551127829 0.3032972728253509 1.6371878522294274 0.05794440201149878 0.1409519296397301 1.7859074892933578e-07 6.748141041488896 0.37637023690732485 EYGMIYLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYGMIYLGK 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 46355100.0 11696000.0 4290100.0 30369000.0 False True 11324716.882066716 6003159.302575954 22414447.84952876 1.0 0.530093543626002 1.9792501731344132 23.43297164755643 -6.819403662168377 1.3744882332601729 0.7465719502670388 2.010475561491049 0.8830017623155417 0.20648663553433597 0.1942553633684533 0.7212838350779381 0.11805928719233018 0.27214710879362575 1.5156409750698135e-07 6.819403662168377 1.26390361122401 EYGMIYLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYGMIYLGK 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 41438100.0 6771100.0 23389000.0 11278000.0 False True 10272253.733717125 19215050.210908912 9048898.356676988 1.0 1.870577840950171 0.8809068186249472 23.292249408063046 -6.674359835103795 1.921524689678629 1.553567283082057 0.8847806353648616 0.29872315355341983 0.36943091842521353 0.4511502251492283 3.215333553247834 0.15453921137218798 0.41061600796287834 2.116606692049216e-07 6.674359835103795 -0.6687866477171954 EYGMIYLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYGMIYLGK 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 47454000.0 20445000.0 16259000.0 10750000.0 False True 28004069.005350325 15540623.618676988 8211071.403199639 1.0 0.5549416270795459 0.29320994037083936 24.739133130929577 -8.81413604215437 0.1962773100824368 1.3717284233350235 4.454803276184718e-16 0.999652658149825 0.005437622250470736 0.33286221290148627 0.058984963353473294 0.21458995470444447 0.13668288337546505 1.5341363414056802e-09 8.81413604215437 -1.371728423335023 down EYGMIYLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYGMIYLGK 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 24795300.0 11696000.0 8001600.0 5097700.0 False True 9725742.220653426 7958493.792606761 6163605.500898279 1.0 0.8182916647437184 0.6337414010222632 23.213376922990705 -6.970931941044313 0.23486414376448095 1.0706343900614732 0.3760944038369389 0.9999887651660224 0.0005011538539295527 0.07600147462030335 0.007940020846924535 0.0045765407172611615 0.018160792170477398 1.0692224255835959e-07 6.970931941044313 -0.6945399862245343 EYGMIYLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYGMIYLGK 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 41166100.0 6771100.0 19015000.0 15380000.0 False True 8765322.428335179 17956798.53447165 12580997.812126476 1.0 2.0486181405516457 1.4353148917211045 23.063375730155496 -10.619376336057716 6.436619906767935 0.9973669782033363 1.741966516136375 0.6611831718725436 0.25038000287100165 0.009479586251864994 0.0005605656440336096 0.24291865102751004 0.08080979844522952 2.402280211988705e-11 10.619376336057716 0.7445995379330388 EYHPDK(ub)NPNAGDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYHPDKNPNAGDK 13 1 O60884;I3L320 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 51211900.0 9892900.0 15835000.0 25484000.0 True False 12969687.702979892 13472479.72434655 22847160.13978937 1.0 1.0387667022430414 1.7615813628681318 23.62864040557551 -6.917985193024424 0.8395177712598203 0.982865283572079 1.8729124753328166 0.9936032689143414 0.028011504228112726 0.09937127032013669 0.11185776245503608 0.02388096383440342 0.07021497243536858 1.2078550154016683e-07 6.917985193024424 0.8900471917607375 EYHPDK(ub)NPNAGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYHPDKNPNAGDK 13 1 O60884;I3L320 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 63334000.0 11739000.0 18541000.0 33054000.0 True False 11366351.87060374 25944517.9900377 24396165.801255397 1.0 2.282572129157534 2.14634968888743 23.438265947225943 -10.424351130235218 6.169393131349427 0.9996588233947703 2.2144609090224816 0.9906521297267287 0.05561257836308619 0.00026104075109824456 2.4357058243990947e-05 0.05386049897996994 0.017948882486657228 3.7639935432253524e-11 10.424351130235218 1.2148020856277113 EYHPDK(ub)NPNAGDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYHPDKNPNAGDK 13 1 O60884;I3L320 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 35129000.0 12865000.0 11993000.0 10271000.0 True False 19517145.55748268 9852755.448263321 8240932.348060778 1.0 0.504825637501375 0.4222406562368075 24.218238733957048 -13.999999999999998 0.2520197093688478 4.479067407673719 0.389666707949065 0.9995465212850779 0.0054330093825564725 14.07895003490988 0.1588525637705053 24.826460750480255 0.03768925079768424 1.0000000000000041e-14 13.999999999999998 -4.089400699724655 EYHPDK(ub)NPNAGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYHPDKNPNAGDK 13 1 O60884;I3L320 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 54584900.0 9892900.0 14903000.0 29789000.0 True False 13550572.475570107 14244536.182369338 22753451.723712925 1.0 1.051212870013452 1.679150586791399 23.6918504670984 -6.923084757396557 0.8015116701738556 0.9876243552524507 1.7879639438698238 0.9949959042959916 0.021843851911910052 0.09639045640282588 0.09645555141241453 0.01913501080830458 0.0591241645215628 1.1937551071478735e-07 6.923084757396557 0.8003395886173731 EYHPDK(ub)NPNAGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYHPDKNPNAGDK 13 1 O60884;I3L320 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 46341000.0 11739000.0 15320000.0 19282000.0 True False 9761498.62587643 15237468.119218102 23313777.050105065 1.0 1.5609763114472615 2.388339940785665 23.21867122266022 -6.96553654646976 0.3487210385536254 0.9188594942691021 3.05832025207604 0.999923782364509 0.004978473979837726 0.07777934938932994 0.014220584623488977 0.011394321212556423 0.07117491298407934 1.0825886099940114e-07 6.96553654646976 2.1394607578069382 EYHPDK(ub)NPNAGDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYHPDKNPNAGDK 13 1 O60884;I3L320 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 38919200.0 12865000.0 9410200.0 16644000.0 True False 16653996.107062696 8886514.097769378 13614962.781861728 1.0 0.5335965038445486 0.817519272511889 23.989365056049497 -10.32124097518149 6.027942270935243 1.0000262794941992 0.6755578881782192 0.6351770952646304 0.11591098493220994 4.0939979446468885e-05 4.610051260514572e-06 0.11223940327556747 0.03741010952374546 4.772643824625986e-11 10.32124097518149 -0.32446839131598004 EYHPDK(ub)NPNAGDK(ub)FK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYHPDKNPNAGDKFK 15 2 O60884 O60884 DNAJA2 DnaJ homolog subfamily A member 2 2 6135700.0 0.0 3205600.0 2930100.0 True False 0.0 2633535.6345328824 2350964.4506915477 0.0 EYHPDK(ub)NPNAGDK(ub)FK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYHPDKNPNAGDKFK 15 2 O60884 O60884 DNAJA2 DnaJ homolog subfamily A member 2 2 6876200.0 0.0 2614900.0 4261300.0 True False 0.0 2469378.516318162 3485787.1246303366 0.0 EYHPDKNPNAGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYHPDKNPNAGDK 13 1 O60884;I3L320 O60884 DNAJA2 DnaJ homolog subfamily A member 2 0 6403300.0 1763700.0 1228600.0 3411000.0 False True 1707712.3089005684 1719186.3870643592 2517556.7721934407 1.0 1.0067189760851334 1.4742276899170759 20.703633519996043 -6.910029349647357 0.8955347305604845 0.9855383145806117 1.534683289985042 0.9909325927753919 0.021138190557652748 0.10439876807380213 0.13866212355098378 0.01730860797234435 0.04778932184851527 1.2301856319837276e-07 6.910029349647357 0.5491449754044303 EYHPDKNPNAGDK(ub)FK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYHPDKNPNAGDKFK 15 2 O60884 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 162532000.0 42871000.0 68534000.0 51127000.0 True False 65038441.28992149 56303572.24141403 41021726.04023981 1.0 0.8656968267494284 0.6307304607344062 25.95478934643618 -6.96257480437994 0.39748636667015014 1.013279999621037 0.4746025370302915 0.9998540927203798 0.0018433911490107094 0.07879388442965403 0.0178246314500602 0.0030246841840906153 0.019705103969823407 1.0899967314176333e-07 6.96257480437994 -0.5386774625907456 EYHPDKNPNAGDK(ub)FK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYHPDKNPNAGDKFK 15 2 O60884 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 160735600.0 42871000.0 57108000.0 60756600.0 True False 55497354.61374931 53929889.59803342 49699522.21536043 1.0 0.9717560408667199 0.8955295718374209 25.72591566852863 -6.953801745197896 0.5154232244692257 1.0013426402301475 0.8625677432369299 0.9994668139957263 0.001018840694354139 0.08199417275772293 0.02991571837838717 0.0011628110673013593 0.006293716435931047 1.1122393470602726e-07 6.953801745197896 -0.13877489699321766 EYK(ub)EAIHDMNFSNEDMIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYKEAIHDMNFSNEDMIR 18 1 A2RQR6;Q96EI5;Q96EI5-2 A2RQR6 TCEAL4 Transcription elongation factor A protein-like 4 1 23810700.0 3604100.0 9901600.0 10305000.0 True False 5467683.19500375 8134582.118446093 8268212.233158042 1.0 1.4877566655433325 1.5121966540990075 22.382498222978114 -11.603741030408736 0.48240272283737645 8.573017067046008e-11 1.511453258658208 0.9998469584261238 0.0029183416848748093 4.523479219810059 0.23825950507775964 4.703788638295862 0.005145991512188487 2.4903418652809262e-12 11.603741030408736 1.5114532585724778 EYK(ub)EAIHDMNFSNEDMIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYKEAIHDMNFSNEDMIR 18 1 A2RQR6;Q96EI5;Q96EI5-2 A2RQR6 TCEAL4 Transcription elongation factor A protein-like 4 1 19862500.0 3604100.0 7881600.0 8376800.0 True False 4665578.497432148 7442982.031516786 6852308.353226339 1.0 1.5952967109251879 1.4686942588143632 22.153624545070564 -10.076173880604479 4.510332936887067 0.9999676308450013 1.5319954848441262 0.9592559572927406 0.05168523478488704 17946259.28855928 0.4213110403336386 6753.682906890427 0.01769323059182615 8.391239550952143e-11 10.076173880604479 0.5320278539991249 EYK(ub)IDEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYKIDEK 7 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 15657900.0 6377300.0 6881700.0 2398900.0 True False 6174856.1022575265 9629598.697591403 1770556.1245426123 1.0 1.5594855229210642 0.28673641866654953 22.55797408610596 -6.787187943269509 1.5073659004859699 1.313832435021991 0.2741869529113017 0.7921799318315623 0.23744608640247442 0.23954592669212685 1.0752558460870743 0.12400709171422962 0.29095964057323925 1.6323453887879018e-07 6.787187943269509 -1.0396454821106893 down EYK(ub)IDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYKIDEK 7 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 15682100.0 5916900.0 5836800.0 3928400.0 True False 8104537.8282102 5578910.87628353 3000592.8279376244 1.0 0.6883687872816768 0.37023614320031784 22.950298485855317 -7.13839464816716 0.2564588757542569 1.1021003423463382 4.123854549915406e-12 0.9999739361622393 0.001312577035688003 0.08113894629139175 0.011026747856911647 0.009170468516216094 0.033926715830305404 7.271187634257063e-08 7.13839464816716 -1.1021003423422144 down EYK(ub)VVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYKVVGR 7 1 Q02543;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 1 126324000.0 27492000.0 53274000.0 45558000.0 True False 36042278.23290675 45325726.86042559 40844095.18319429 1.0 1.2575710827026192 1.133227342601874 25.103186871018792 -10.149878489361734 4.1701810985539955 0.9999478704814591 1.1953992126772195 0.7670399340716993 0.0507631194539781 7156423.17020217 8709075.484977966 2877.3395030462916 0.01737756586093585 7.081438872450865e-11 10.149878489361734 0.19545134219576044 EYK(ub)VVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYKVVGR 7 1 Q02543;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 1 245749000.0 68870000.0 80537000.0 96342000.0 True False 66683759.54753204 112695844.09490678 71107140.00195271 1.0 1.690004355776873 1.0663336993060162 25.990832108183163 -10.30331984583314 4.733306989311625 0.9998094166688543 1.378169027542008 0.32896271603376903 0.25461247931863673 0.0005123276380636176 7.540791126092133e-05 0.2466506323999375 0.08217582434453086 4.9737065038034327e-11 10.30331984583314 0.37835961087315373 EYK(ub)VVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYKVVGR 7 1 Q02543;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 1 116679000.0 27492000.0 35931000.0 53256000.0 True False 37656535.343364775 34343449.612072274 40678029.64174883 1.0 0.9120183070194141 1.0802382447252004 25.166396932541684 -6.76458309623341 1.5952270989496886 0.9491879161979532 1.0809960314890246 0.7094073025770362 0.0370337341984912 0.2752764167082979 1.3815732012868145 0.018308679016162215 0.04380172881873285 1.7195582960989204e-07 6.76458309623341 0.1318081152910714 EYK(ub)VVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYKVVGR 7 1 Q02543;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 1 221780000.0 68870000.0 104030000.0 48880000.0 True False 57268456.458310656 103469569.74166177 59100582.00441528 1.0 1.8067462638352028 1.0319918792894016 25.77123738361744 -10.459376775359127 4.833387436407089 0.9989777553329392 1.4193690715623621 0.28091906848254544 0.3162921530204282 0.0034921847321148516 0.0003906073518184577 0.3069549418743632 0.10208285343198552 3.472347846502526e-11 10.459376775359127 0.42039131622942294 EYLESLQCLESDK(ub)SDWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYLESLQCLESDKSDWR 17 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 1 15734900.0 5399200.0 8181900.0 2153800.0 True False 7078403.485927184 6961192.4127964 1930945.4367084557 1.0 0.9834410296949283 0.2727939203448114 22.754992570498896 -6.911919005723233 0.8825659172180317 1.0206906683021655 0.17708316684464215 0.9916256705090557 0.03101984974558275 0.10316305496193443 0.13198597715009192 0.025639736079145225 0.07175454918982622 1.2248446068480975e-07 6.911919005723233 -0.8436075014575233 down EYLESLQCLESDK(ub)SDWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYLESLQCLESDKSDWR 17 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 1 54901000.0 32200000.0 11386000.0 11315000.0 True False 48849754.13532391 9354079.340775961 9078585.29045933 1.0 0.19148672304190578 0.18584710304395335 25.541847965225227 EYLESLQCLESDK(ub)SDWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYLESLQCLESDKSDWR 17 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 1 18934400.0 5399200.0 8739500.0 4795700.0 True False 7395430.147893754 8353359.99233826 3663054.430541811 1.0 1.1295299698986851 0.49531323496917384 22.818202632021787 -6.853491301544098 1.2179717437955895 1.0693947612025614 0.46817882579512404 0.9452446348339548 0.06402226480130749 0.15366640992165995 0.4368910651136986 0.04108902541732945 0.09532854656150228 1.401227649756317e-07 6.853491301544098 -0.6012159354074373 down EYLESLQCLESDK(ub)SDWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYLESLQCLESDKSDWR 17 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 1 15636600.0 10137000.0 3384500.0 2115100.0 True False 8429364.645243144 3366267.0267293486 2557357.6308825486 1.0 0.39935003032867955 0.3033867602732925 23.006992462923225 -13.999999999999998 0.2581328820615889 5.354574805587395 0.2676804644620168 0.999558547507165 0.006476934016182656 14.335317397471677 0.16077197779207084 32.5261652887705 0.04237040196741372 1.0000000000000041e-14 13.999999999999998 -5.086894341125379 EYLESLQCLESDK(ub)SDWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYLESLQCLESDKSDWR 17 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 1 52875700.0 32200000.0 11887000.0 8788700.0 True False 41683534.75689224 11225478.000487199 7189246.779677239 1.0 0.26930244917943535 0.1724721001135471 25.312974287317676 -13.999999999999998 0.2848540234481665 7.117439399846756 0.14469015956972966 0.9996159636935722 0.007239043135473693 15.66706065408383 0.169151005560599 55.99471897660382 0.03744146750927925 1.0000000000000041e-14 13.999999999999998 -6.972749240277026 EYLESLQK(ub)ELVEDN ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYLESLQKELVEDN 14 1 Q96GN5-5;Q96GN5-4;Q96GN5-2;Q96GN5 Q96GN5-5 CDCA7L Cell division cycle-associated 7-like protein 1 6070500.0 2162500.0 2518300.0 1389700.0 True False 2835058.441679792 2142579.4562565153 1245907.1749437002 1.0 0.7557443701185299 0.43946437104326197 21.43494704440441 -6.967585789718741 0.31048999920821096 1.0484444785550393 0.13670357721291632 0.999956954378947 0.001505499671894619 0.07709416220067519 0.011820357735297517 0.004993143185599599 0.028066321472541372 1.0774923868418571e-07 6.967585789718741 -0.9117409013421229 down EYLESLQK(ub)ELVEDN ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYLESLQKELVEDN 14 1 Q96GN5-5;Q96GN5-4;Q96GN5-2;Q96GN5 Q96GN5-5 CDCA7L Cell division cycle-associated 7-like protein 1 10509500.0 2162500.0 6249000.0 2098000.0 True False 2962034.689365136 5972898.517320417 1602495.6096663096 1.0 2.0164849988980413 0.5410117631032129 21.4981571059273 -6.721326547476531 1.7544323711774354 1.6175389779082072 0.5431228385382882 0.5188044191993363 0.42767302535092117 0.35275392757746205 2.122667676870217 0.19349636351669153 0.4850121317193178 1.8996493900538028e-07 6.721326547476531 -1.074416139369919 EYLESLQK(ub)ELVEDN ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYLESLQKELVEDN 14 1 Q96GN5-5;Q96GN5-4;Q96GN5-2;Q96GN5 Q96GN5-5 CDCA7L Cell division cycle-associated 7-like protein 1 10066700.0 4299900.0 5766800.0 0.0 True False 3575557.367868302 5735733.103779824 0.0 1.0 1.6041507697020645 0.0 21.769736720077493 -6.820586181369508 1.475695761505006 1.3303681508038556 4.359282177363478e-22 0.8448962575154308 0.26052185543684864 0.20512108956513908 0.8946109763812179 0.1409465193236179 0.309240398528511 1.511519723719896e-07 6.820586181369508 -1.3303681508038556 EYLESLQK(ub)ELVEDN ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYLESLQKELVEDN 14 1 Q96GN5-5;Q96GN5-4;Q96GN5-2;Q96GN5 Q96GN5-5 CDCA7L Cell division cycle-associated 7-like protein 1 22397000.0 4640000.0 3935000.0 13822000.0 True False 6006571.468073916 3716013.7908570045 11306537.82569649 1.0 0.6186580498722664 1.8823613247245816 22.51811030944327 -6.825776331970567 1.3466825751315097 0.7955706645694213 1.9135244522833772 0.8971632686676697 0.16972006827404523 0.1860779564549731 0.6614551021105062 0.09899328147284633 0.22789158464494355 1.4935634186082171e-07 6.825776331970567 1.1179537877139558 EYLGAICSCTCFGGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYLGAICSCTCFGGQR 16 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 28566800.0 7162800.0 11078000.0 10326000.0 False True 9390500.164653873 9425205.581705786 9257564.573986223 1.0 1.003695800696809 0.9858436091436297 23.162770571276557 -6.8527407865402905 1.222042796998087 1.0019775998494658 0.9850923498010081 0.9441624463540088 0.0018180546460674078 0.15447380905504438 0.44258667129461465 0.0011633563097079064 0.002696799660052688 1.4036512393412143e-07 6.8527407865402905 -0.016885250048457645 EYLGAICSCTCFGGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYLGAICSCTCFGGQR 16 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 21964700.0 7162800.0 7337200.0 7464700.0 False True 9811080.727391714 7013018.24312423 5701691.6003222605 1.0 0.7148058850993317 0.5811481689681358 23.22598063279945 -13.999999999726779 0.10113658448057622 2.403870708700636 0.301421735170426 0.9997880107140419 0.002543396364668216 12.071856194644964 0.0949365760956435 3.527095156705278 0.2493212138896565 1.0000000006291156e-14 13.999999999726779 -2.10244897353021 EYLTK(ub)VDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYLTKVDK 8 1 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 24167300.0 7144100.0 8092800.0 8930400.0 True False 9365984.28356281 6885385.7854873305 8006367.874445729 1.0 0.7351481250690438 0.8548346475977767 23.158999186472297 -10.041590099154607 4.515856042851724 1.0000092190011607 0.7949913863869128 0.7964145499870535 0.04886181826499059 33815351.00072669 1.2975387247465653 3386.8893793912803 0.01672670003266459 9.086777643387943e-11 10.041590099154607 -0.20501783261424789 EYLTK(ub)VDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYLTKVDK 8 1 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 25959600.0 5437700.0 7907900.0 12614000.0 True False 5265083.189946493 11065565.709153706 9310014.988111435 1.0 2.101688674223239 1.7682560089247228 22.32802489578411 -10.179749176161701 5.621601915969623 0.999977110421419 1.9349723415740365 0.9129210386346795 0.13612331559314142 3.905512093831964e-05 5.698755098416008e-06 0.13180404867321835 0.043933611193533485 6.6107513724669e-11 10.179749176161701 0.9349952311526175 EYLTK(ub)VDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYLTKVDK 8 1 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 28188600.0 8070000.0 12436000.0 7682600.0 True False 12242779.996026808 10216698.63708852 6164130.742596793 1.0 0.8345080643778766 0.5034910979856911 23.545427855501025 -6.960043125220369 0.43482922233731136 1.0124944980337942 0.31270904229579005 0.9997717854202789 0.0031183263509751325 0.07968577954629612 0.021074752026848678 0.0043378968838950396 0.027455234605707136 1.096369321823673e-07 6.960043125220369 -0.6997854557380041 EYLTK(ub)VDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYLTKVDK 8 1 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 20861200.0 7144100.0 5018200.0 8698900.0 True False 9785466.83204321 4796479.331031732 6644398.979469147 1.0 0.4901635673962246 0.6790068469407701 23.22220924799519 -10.08080666941519 5.09928297792093 1.000008536012719 0.5845852071673029 0.8658092339995909 0.07709494604380723 7.481748930401443e-06 1.348557258690246e-06 0.07464839366629727 0.024882286841438804 8.30220266220773e-11 10.08080666941519 -0.4154233288454162 EYLTK(ub)VDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYLTKVDK 8 1 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 26854200.0 5437700.0 12260000.0 9156500.0 True False 4521688.480954783 12193952.94658053 11071081.815127432 1.0 2.6967698013565276 2.4484397502743716 22.108430171218387 -10.127287333723812 5.1018437504571885 0.9999445149587037 2.5726047758180375 0.9816416511814142 0.1013803188340987 6.398438277787304e-05 1.0944794777849972e-05 0.09816449252538328 0.03272035720517948 7.459550635212143e-11 10.127287333723812 1.5726602608593336 EYLTK(ub)VDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYLTKVDK 8 1 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 21496700.0 8070000.0 6836100.0 6590600.0 True False 10446774.083481979 6455665.025585147 5391178.425266628 1.0 0.617957751742003 0.5160615499277373 23.316554177593474 -13.999999999999998 0.1854974195911335 3.0171357622737167 0.43955356724538275 0.9994925268785811 0.004692618187474667 12.280812866175376 0.13656939492728332 8.941173874308635 0.07266839869022887 1.0000000000000041e-14 13.999999999999998 -2.577582195028334 EYLTK(ub)VDKLDASESLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYLTKVDKLDASESLR 16 2 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 26585800.0 5341300.0 12240000.0 9004500.0 True False 7002496.025222779 10413839.711146316 8072800.71726311 1.0 1.4871611027890597 1.1528461691638419 22.73943782871742 -10.120989243558913 4.703046892920229 0.9999806327788834 1.3200036358251588 0.5498785148812684 0.13648350016375627 3.363672321801737e-05 6.286918711928278e-06 0.13215927876772662 0.04404986025875549 7.568516402033387e-11 10.120989243558913 0.3200230030462754 EYLTK(ub)VDKLDASESLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYLTKVDKLDASESLR 16 2 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 21009500.0 6146100.0 7685300.0 7178100.0 True False 5950995.419705052 10754080.368310038 5297940.271615882 1.0 1.8071061410501037 0.8902611912745285 22.5046995767294 -6.674280091073095 1.9223924460071942 1.5132763584910733 0.8939078297243408 0.298029523161464 0.3425088877931015 0.4513823981402215 3.2199904365752086 0.14323548333984076 0.38053959941576 2.1169953735846846e-07 6.674280091073095 -0.6193685287667325 EYLTK(ub)VDKLDASESLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYLTKVDKLDASESLR 16 2 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 22553100.0 5341300.0 10141000.0 7070800.0 True False 7316122.953205081 9692937.088197513 5400822.667697105 1.0 1.3248734541771454 0.7382082972417908 22.802647890240312 -6.756352729095937 1.6259081604894028 1.1895520917709614 0.7364202738547992 0.6760463841457258 0.13658133430643263 0.28907313523797984 1.50520799927259 0.06630311753808481 0.15993441301973976 1.7524565981325577e-07 6.756352729095937 -0.4531318179161622 EYLTK(ub)VDKLDASESLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYLTKVDKLDASESLR 16 2 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 1 25264500.0 6146100.0 9438300.0 9680100.0 True False 5110754.468395867 9387454.004544122 11704164.154274564 1.0 1.8368039518616512 2.2901049593854186 22.285104852163677 -9.378667655283518 0.16958778912708916 1.8739293209598246e-21 2.889380333270784 0.9996957826787373 0.009320626164906606 0.8200877222731778 0.06490914874441366 0.7283375999471046 0.3172344060287372 4.1815023454030266e-10 9.378667655283518 2.889380333270784 EYNEYENIK(ub)LER ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYNEYENIKLER 12 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-14;A0A0C4DGN9 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 11316100.0 0.0 4586400.0 6729700.0 True False 0.0 3902126.997647177 6033375.1998407 0.0 EYNEYENIK(ub)LER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYNEYENIKLER 12 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-14;A0A0C4DGN9 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 25428300.0 3559900.0 7389400.0 14479000.0 True False 3446892.923090738 10340025.95521193 10686515.539310724 1.0 2.9998106079664066 3.1003329020526715 21.716865051746968 -10.4589762411366 0.5909948548825671 1.3594134340880223e-19 3.089167010610434 0.9997923801197426 0.01393761446270574 1.8422744301045333 0.2867457579406018 2.8716561444313258 0.017660819807180924 3.475551745561814e-11 10.4589762411366 3.089167010610434 EYNEYENIK(ub)LER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYNEYENIKLER 12 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-14;A0A0C4DGN9 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 9947600.0 0.0 3182900.0 6764700.0 True False 0.0 3042268.9535572333 5167017.183369721 0.0 EYNEYENIK(ub)LER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYNEYENIKLER 12 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-14;A0A0C4DGN9 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 18929900.0 3559900.0 4214400.0 11155600.0 True False 2960214.580309858 4191696.1907070978 13488184.382333402 1.0 1.4160109265688217 4.556488732962573 21.497270327181244 -6.931192323087145 0.7369395741948292 0.9542932868275529 5.221234919423845 0.996767439208294 0.09026400015591625 0.09202340102446424 0.07468175047387424 0.08282592678994354 0.28231893302365607 1.1716763851530491e-07 6.931192323087145 4.266941632596293 up EYNFTRPNEK(ub)GEYEIAEGISATVFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYNFTRPNEKGEYEIAEGISATVFR 25 2 Q7Z5Y7;Q7Z5Y7-3 Q7Z5Y7 KCTD20 BTB/POZ domain-containing protein KCTD20 1 35388400.0 6069400.0 19239000.0 10080000.0 True False 9207723.532575617 15805650.135006903 8087683.581779045 1.0 1.7165643689331853 0.878358646756277 23.1344130856603 -6.680324019658162 1.900549299656807 1.4532396717005465 0.8815256598850716 0.3256997136231119 0.303674253692647 0.437797915771878 3.0576427939782067 0.12819237128416788 0.33798163646662693 2.0877379242220516e-07 6.680324019658162 -0.5717140118154749 EYQAK(ub)ENDFDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYQAKENDFDR 11 1 M0QXB4;O14579-2;O14579;O14579-3 M0QXB4 COPE Coatomer subunit epsilon 1 3366490.0 845320.0 1433170.0 1088000.0 True False 1108222.7060905253 1219346.6224529038 975424.1968329474 1.0 1.1002721887502107 0.8801698354240992 20.079816400789465 -6.7828107158937 1.5246379533845953 1.0565681955466948 0.8782609776161708 0.7773179910038509 0.04245827957474678 0.24622150892335418 1.1306017748091524 0.021928673160240015 0.051628363937523576 1.6488808877379545e-07 6.7828107158937 -0.17830721793052395 EYQAK(ub)ENDFDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYQAKENDFDR 11 1 M0QXB4;O14579-2;O14579;O14579-3 M0QXB4 COPE Coatomer subunit epsilon 1 8093900.0 1506800.0 1534400.0 5052700.0 True False 1458967.4587806198 2147093.9217902916 3729246.292249137 1.0 1.471653057693827 2.5560859975355297 20.47651627466402 -6.957230113272237 0.47286173963491224 0.9721393627566296 3.1002706147737644 0.9996532549196251 0.012131298560248312 0.08070590769497656 0.024903405089990404 0.015075863157304074 0.08948715904481376 1.1034937728498091e-07 6.957230113272237 2.128131252017135 EYQAK(ub)ENDFDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYQAKENDFDR 11 1 M0QXB4;O14579-2;O14579;O14579-3 M0QXB4 COPE Coatomer subunit epsilon 1 32529800.0 2463400.0 10498100.0 19568300.0 True False 3737157.8986632586 8624632.032970311 15700616.927909432 1.0 2.307805093291683 4.2012185071241905 21.833510089640637 -6.965839412954773 0.3433410916332992 0.8024201335475307 5.769846904491416 0.9999294176179999 0.011040700223940516 0.07767725290572798 0.013861965029008416 0.02646407868613233 0.16348899988616347 1.081833902026207e-07 6.965839412954773 4.967426770943885 EYQAK(ub)ENDFDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYQAKENDFDR 11 1 M0QXB4;O14579-2;O14579;O14579-3 M0QXB4 COPE Coatomer subunit epsilon 1 3898320.0 845320.0 1243100.0 1809900.0 True False 1157857.6479140513 1188175.7316180207 1382438.8960605578 1.0 1.026184638291753 1.1939627453781583 20.143026462312356 -6.934459577380146 0.7092215171022687 0.9978215363961284 1.2326763576923419 0.9973445982776028 0.004428052874165027 0.09038712471961183 0.0668124124960432 0.004147147238424821 0.014826415854072102 1.1628947841681346e-07 6.934459577380146 0.2348548212962135 EYQAK(ub)ENDFDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYQAKENDFDR 11 1 M0QXB4;O14579-2;O14579;O14579-3 M0QXB4 COPE Coatomer subunit epsilon 1 7106340.0 1506800.0 2403300.0 3196240.0 True False 1252970.9625581894 2390352.945882302 3864559.0062559857 1.0 1.9077480782171685 3.084316493947888 20.256921550098298 -6.967570955636484 0.3107816021009345 0.8204047631499576 4.209101725505895 0.9999567567139248 0.005611097802482058 0.07709905259143476 0.011837422219074259 0.018550300882858112 0.10437801088191695 1.0775291910941344e-07 6.967570955636484 3.3886969623559375 EYQAK(ub)ENDFDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYQAKENDFDR 11 1 M0QXB4;O14579-2;O14579;O14579-3 M0QXB4 COPE Coatomer subunit epsilon 1 28363300.0 2463400.0 3865800.0 22034100.0 True False 3188919.860873551 3650664.831688691 18024119.888958134 1.0 1.1447966681384876 5.652108135455222 21.604636411733086 -6.913740832646431 0.8698782184563686 0.8764089075266059 6.283720226695883 0.9922582415807704 0.19002653512538928 0.10199579265842348 0.12573555325614275 0.15851428515934254 0.4497848059349406 1.219717254016962e-07 6.913740832646431 5.407311319169278 up EYSQK(ub)VLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYSQKVLER 9 1 E9PKV8;Q8N5M4 E9PKV8 TTC9C Tetratricopeptide repeat protein 9C 1 4240110.0 876210.0 1185100.0 2178800.0 True False 848395.1931631055 1658316.6102148553 1608106.9174010763 1.0 1.9546511149268628 1.8954691520652154 19.694376921307878 -10.566399477239724 6.461881097215036 0.9985402029625113 1.9250601334959065 0.9969396650362625 0.024160935164563874 0.0005086845756465872 3.4133376599380485e-05 0.023419546189100828 0.007797908293429358 2.7139417544113635e-11 10.566399477239724 0.9265199305333952 EYSQK(ub)VLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYSQKVLER 9 1 E9PKV8;Q8N5M4 E9PKV8 TTC9C Tetratricopeptide repeat protein 9C 1 7114200.0 778800.0 2498000.0 3837400.0 True False 1181496.5379065296 2052212.3830369175 3078936.2080078335 1.0 1.736960132505502 2.6059629539527385 20.172183971168817 -6.968947848472155 0.2821902216866849 0.81353324285102 3.5559496538945257 0.9999729715382928 0.0034123903692301993 0.07664562001219863 0.01024682323298431 0.015851679944825184 0.07954538103529528 1.0741183883106777e-07 6.968947848472155 2.7424164110435054 EYSQK(ub)VLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYSQKVLER 9 1 E9PKV8;Q8N5M4 E9PKV8 TTC9C Tetratricopeptide repeat protein 9C 1 3141670.0 876210.0 1370900.0 894560.0 True False 728607.437684571 1363514.689597656 1081608.360021885 1.0 1.871398257929875 1.4844871244508697 19.474782196742154 -10.07876628843435 4.42379955893267 0.9999483643140412 1.677942690891111 0.8036740532945312 0.1579558090107851 73146492.65842715 73813094.88291173 50421.80082409296 0.05780590726949986 8.341299431886743e-11 10.07876628843435 0.6779943265770698 EYSQK(ub)VLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYSQKVLER 9 1 E9PKV8;Q8N5M4 E9PKV8 TTC9C Tetratricopeptide repeat protein 9C 1 4440900.0 778800.0 1320900.0 2341200.0 True False 1008171.9524430953 1247390.753835582 1915125.6227406068 1.0 1.2372797624579712 1.8996021641940124 19.943310293261266 -6.9530594773106715 0.5241821040226243 0.9890982599557341 2.1775527544721225 0.9994200172893226 0.009167854701158967 0.08228000714886387 0.031054478672219284 0.010318205426776363 0.05473217631123169 1.1141419396563395e-07 6.9530594773106715 1.1884544945163884 EYTAAVEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYTAAVEAK 9 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6;U3KPZ5 Q99623 PHB2 Prohibitin-2 0 6578560.0 3330000.0 2310800.0 937760.0 False True 2769042.5440129894 2298351.261742111 1133841.2802876555 1.0 0.8300165942597845 0.40947051634838905 21.400955788996892 -6.955685166706339 0.4924964314266059 1.008998507080119 0.21257995730640816 0.9995751831742457 0.005115895359414827 0.08128007294985617 0.027112742246219332 0.006087817709294282 0.0346857296579837 1.1074263001030375e-07 6.955685166706339 -0.7964185497737108 down EYTINIHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYTINIHK 8 0 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2;B8ZZK4 H7C2W9 RPL31 60S ribosomal protein L31 0 120094000.0 37694000.0 37271000.0 45129000.0 False True 49417199.0292153 31710312.081220135 40459483.987935655 1.0 0.6416857431048064 0.8187328457045113 25.55850990512552 -10.152033278617365 4.9801537974976755 1.0000161444065696 0.7302092944040497 0.7558653670257707 0.07227917697002086 101143508.82407494 0.5902240096059344 18724.930330136383 0.02474308478992243 7.046390726270922e-11 10.152033278617365 -0.2698068500025199 EYTINIHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYTINIHK 8 0 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2;B8ZZK4 H7C2W9 RPL31 60S ribosomal protein L31 0 70981000.0 18994000.0 10665000.0 41322000.0 False True 18391045.866789963 14923590.117240274 30498528.56657207 1.0 0.8114595670814392 1.6583357350897299 24.132500189851935 -6.848306090112127 1.2434325191386604 0.8995233757923365 1.6910632559567236 0.9377742011405421 0.09055955543874306 0.1593342412493006 0.47494646763533976 0.05701711081808628 0.13179083381045287 1.4180577244040344e-07 6.848306090112127 0.791539880164387 EYTINIHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYTINIHK 8 0 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2;B8ZZK4 H7C2W9 RPL31 60S ribosomal protein L31 0 86482000.0 19119000.0 52275000.0 15088000.0 False True 29004920.786125977 42946117.823560804 12105850.18669467 1.0 1.4806493746434697 0.4173722892042961 24.789794343469183 -6.783787570027882 1.5209025352745191 1.2708141163796967 0.4078934212153771 0.7806406289744344 0.20361685506813887 0.24472754776404204 1.118292481391651 0.10541696579877877 0.24798621922685318 1.6451762447991468e-07 6.783787570027882 -0.8629206951643196 down EYTINIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYTINIHK 8 0 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2;B8ZZK4 H7C2W9 RPL31 60S ribosomal protein L31 0 100119000.0 37694000.0 19931000.0 42494000.0 False True 51630490.4420483 19050382.51699682 32457792.391401384 1.0 0.3689754320342855 0.6286555117626288 25.62171996664841 -10.348640543881036 5.840988305965754 1.0000785985780916 0.49881547189849784 0.832399588040198 0.10601394861661972 0.00010852592864529233 1.2102344851386366e-05 0.10266354678672969 0.03421585478815417 4.480840201589727e-11 10.348640543881036 -0.5012631266795937 EYTINIHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYTINIHK 8 0 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2;B8ZZK4 H7C2W9 RPL31 60S ribosomal protein L31 0 48110300.0 18994000.0 19668000.0 9448300.0 False True 15794352.576871697 19562044.580207657 11423895.845996687 1.0 1.2385467834150508 0.723289909503803 23.91290546528621 -6.780807888234054 1.5326256860205285 1.1349288495185395 0.7190973009189076 0.7702713173009118 0.10091424994021167 0.24932064294986717 1.1567860330627058 0.05185638112071848 0.12228188703952347 1.6565025614418664e-07 6.780807888234054 -0.4158315485996319 EYTINIHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYTINIHK 8 0 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2;B8ZZK4 H7C2W9 RPL31 60S ribosomal protein L31 0 39656000.0 19119000.0 20537000.0 0.0 False True 24749922.391832966 19394097.896526117 0.0 1.0 0.783602372140198 0.0 24.560920665561632 -7.276893867382243 0.8339944819150992 0.989016617024856 1.4092351208182847e-17 0.9885282174545181 0.04601090628054304 0.10139969989211706 0.13764330966167634 0.03911524351477053 0.06905195952930689 5.285744086810374e-08 7.276893867382243 -0.989016617024856 down EYVDICWVDAEEK(ub)GNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYVDICWVDAEEKGNK 16 1 Q7Z3T8 Q7Z3T8 ZFYVE16 Zinc finger FYVE domain-containing protein 16 1 27874600.0 9525300.0 12055000.0 6294300.0 True False 14450576.492708081 9903691.0638551 5050228.846110312 1.0 0.6853492017327205 0.349482863099525 23.784623713102253 -7.157902004309222 0.2755431139556569 1.0871530124836823 1.355997581299539e-12 0.9999587725551208 0.0017054964222338353 0.08375409832212198 0.012810689667801262 0.009153040287653727 0.03596955315734171 6.95181162945446e-08 7.157902004309222 -1.0871530124823263 down EYVEHTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYVEHTVK 8 0 O75937 O75937 DNAJC8 DnaJ homolog subfamily C member 8 0 3696870.0 1044900.0 613470.0 2038500.0 False True 1011730.2214493441 858431.7702037874 1504555.6963108582 1.0 0.8484789245240193 1.4871115485267623 19.94839321502451 -6.844122961666269 1.2630993909926687 0.9193855347175043 1.5098920818541617 0.9313159004913439 0.07140418387491211 0.1640366892649088 0.5065764677189116 0.0442945607557703 0.1021882207246365 1.4317824617420334e-07 6.844122961666269 0.5905065471366574 EYVESQLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYVESQLQR 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 47870000.0 0.0 23408000.0 24462000.0 False True 0.0 19915617.64366933 21930906.89607309 0.0 EYVESQLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYVESQLQR 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 45871300.0 11563000.0 4121300.0 30187000.0 False True 11195938.89426619 5766956.582295571 22280119.109411765 1.0 0.5150936099918355 1.9900179270201404 23.416472182246103 -6.818131368235078 1.3799827977602785 0.7381362434678931 2.0209344599981645 0.8800241776042979 0.21260254902985556 0.19591952150161251 0.7336279805237622 0.12108261148069834 0.27921875346070063 1.5200876541282466e-07 6.818131368235078 1.2827982165302714 EYVESQLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 EYVESQLQR 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 126915700.0 2418000.0 122110000.0 2387700.0 False True 3668282.7794786687 100318516.45021527 1915770.0484339138 1.0 27.347541746624124 0.5222525534703135 21.806673426585007 -12.948741420135889 3.6123315819643816e-11 8.79661044454687 16.486201862550036 0.0 12.89271946108865 0.0 0.6244666357269743 560926759.1435074 560926754.834514 1.1252747655534732e-13 12.948741420135889 7.689591418003166 EYVESQLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 EYVESQLQR 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 41324000.0 0.0 19109000.0 22215000.0 False True 0.0 18264701.194987297 16968274.532286476 0.0 EYVESQLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYVESQLQR 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 16520900.0 11563000.0 3117600.0 1840300.0 False True 9615146.827754404 3100804.870004851 2225098.221414187 1.0 0.3224916816719102 0.23141593792321252 23.19687745768038 -13.999999999999998 0.282802200552208 6.60781183763439 0.20474706080094732 0.9996113947868378 0.0067590033782014185 15.551896177695202 0.1685048120491155 50.52444079428099 0.035554379531646 1.0000000000000041e-14 13.999999999999998 -6.4030647768334426 EYVESQLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 EYVESQLQR 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 10818700.0 2418000.0 4718300.0 3682400.0 False True 3130148.6659057564 4455722.457280959 3012240.984614727 1.0 1.4234858892849511 0.9623316034234077 21.577799748677457 -6.665231546038571 1.9544207972935874 1.2714078850722617 0.9642335893139915 0.2580940990875368 0.1800871581547573 0.4721247387570846 3.472069686955781 0.0743061354996418 0.19975959432691592 2.161565768033111e-07 6.665231546038571 -0.30717429575827015 EYWMDPEGEMK(ub)PGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYWMDPEGEMKPGR 14 1 P53999 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 1 3605800.0 1461000.0 0.0 2144800.0 True False 1414621.3547109668 0.0 1583012.5373792134 1.0 0.0 1.119036222737251 20.43198451440749 -10.683737183677197 4.334365223365519 1.0187555370196666 0.5595181113684958 0.17121716679318022 0.45684462490005856 0.08339499130232113 0.006085023609060828 0.44552179903234296 0.14744596867013088 2.071394488344515e-11 10.683737183677197 -0.45923742565117076 EYWMDPEGEMK(ub)PGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 EYWMDPEGEMKPGR 14 1 P53999 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 1 3000100.0 1461000.0 1539100.0 0.0 True False 1214886.2332741665 1530808.562812569 0.0 1.0 1.2600427273646682 0.0 20.212389789841765 -6.895018487340785 1.3086078877518919 1.1354218533146478 2.906720497314363e-19 0.9431306969714857 0.12953196094116914 0.1379018442344471 0.47421093003891907 0.08070237028690093 0.16172117098658764 1.2734488708313477e-07 6.895018487340785 -1.1354218533146478 down EYWMDPEGEMKPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYWMDPEGEMKPGR 14 1 P53999 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 0 14450800.0 5948900.0 1399300.0 7102600.0 False True 5760055.42576323 1958047.7872531028 5242215.9865673315 1.0 0.3399355809139031 0.9100981846668111 22.457651263298885 -10.425011090729454 8.58937484958474 1.0000043173418616 0.625016882790393 0.36577181979504325 0.23276790826854965 1.9244621620695426e-05 1.2883466031366122e-06 0.22537915245551018 0.07512551935463574 3.75827806520294e-11 10.425011090729454 -0.37498743455146855 EYYLLHLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 EYYLLHLQR 9 0 P78318;A0A1W2PR95 P78318 IGBP1 Immunoglobulin-binding protein 1 0 11222900.0 0.0 4955400.0 6267500.0 False True 0.0 4216073.635997916 5618999.222105228 0.0 EYYLLHLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 EYYLLHLQR 9 0 P78318;A0A1W2PR95 P78318 IGBP1 Immunoglobulin-binding protein 1 0 12883400.0 3797900.0 1738000.0 7347500.0 False True 3677337.743365354 2431992.463550264 5422969.329724812 1.0 0.6613459609300398 1.474699825847904 21.810230255601986 -6.7935966967593275 1.4817547466479835 0.8116100748896377 1.4842519618890808 0.8128339532830753 0.14432220238559595 0.23002134583637746 0.9975611550518686 0.07664724499519945 0.17900522378988074 1.6084342160915168e-07 6.7935966967593275 0.6726418869994432 FAADAVK(ub)LER ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAADAVKLER 10 1 P37837 P37837 TALDO1 Transaldolase 1 7395100.0 0.0 3439800.0 3955300.0 True False 0.0 2825940.814719935 3173533.221330427 0.0 FAAFFGNVPIFHIPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAAFFGNVPIFHIPGR 16 0 Q92620;J3KTG2 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 0 34480900.0 12669000.0 12004000.0 9807900.0 False True 16609181.686770521 10213049.991225505 8793072.592020087 1.0 0.614903863647922 0.5294103441004507 23.985477659515418 -13.999999999999998 0.21149132735391424 3.2409129843702944 0.4797767240145874 0.9994909008814159 0.004618345536680642 12.782045249565655 0.14575295409586358 11.910913250316115 0.05011826986690788 1.0000000000000041e-14 13.999999999999998 -2.7611362603557073 FAAFFGNVPIFHIPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAAFFGNVPIFHIPGR 16 0 Q92620;J3KTG2 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 0 308985000.0 89815000.0 107640000.0 111530000.0 False True 86963871.98724534 150621213.33518443 82316947.17171928 1.0 1.73199755131965 0.9465648813773195 26.373912840690345 -6.661984534075108 1.965858147270499 1.470389911854467 0.9498217200051309 0.24420113728237292 0.31151711303813695 0.47966963222917863 3.565587019643501 0.12793432300729876 0.3454124203962143 2.177787325481027e-07 6.661984534075108 -0.5205681918493361 FAAFFGNVPIFHIPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAAFFGNVPIFHIPGR 16 0 Q92620;J3KTG2 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 0 88798000.0 30875000.0 20596000.0 37327000.0 False True 46839632.26484854 16920482.8827175 29949302.08899473 1.0 0.361242863458937 0.6394008799994488 25.481226413582647 -10.420111997761774 6.048848575726781 1.000155251435208 0.5003218717292603 0.8114151297021134 0.11355753473148332 0.00023782574994073068 2.2799826117679266e-05 0.10998525462660994 0.03665053673761704 3.800913640560975e-11 10.420111997761774 -0.49983337970594754 FAAFFGNVPIFHIPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAAFFGNVPIFHIPGR 16 0 Q92620;J3KTG2 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 0 108497000.0 12669000.0 21069000.0 74759000.0 False True 17353071.666851733 20138101.91413405 57102463.90993495 1.0 1.16049206162171 3.2906257178095735 24.04868772103831 -6.921991193781898 0.8098201234474685 0.9562874569029285 3.650372024067905 0.9947164210017002 0.0758894889912597 0.0970143461650316 0.09964634197271706 0.066085629266154 0.20188885804162293 1.196764797940639e-07 6.921991193781898 2.6940845671649765 up FAAFFGNVPIFHIPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAAFFGNVPIFHIPGR 16 0 Q92620;J3KTG2 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 0 186524000.0 89815000.0 45978000.0 50731000.0 False True 74685151.97913705 45730307.38808156 61338617.54635832 1.0 0.6123078841809964 0.8212960129410056 26.15431811612462 -10.175668035537702 5.04566653153807 1.0000196239273988 0.7168019485606506 0.7100074294385098 0.08531904629473261 1.883576173818342e-05 3.0772310108476246e-06 0.08261553070149127 0.02753660378430886 6.673166554339088e-11 10.175668035537702 -0.28321767536674824 FAAFFGNVPIFHIPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAAFFGNVPIFHIPGR 16 0 Q92620;J3KTG2 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 0 81020000.0 30875000.0 26305000.0 23840000.0 False True 39968296.13723744 24841103.626046635 19501364.619056933 1.0 0.6215202054335965 0.4879208398600713 25.252352735675096 -13.999999999999998 0.14510510423816572 2.817730567333538 0.3323291553816822 0.9995833883279616 0.004426687892334634 11.942680496927265 0.1196942271630665 6.1314562955587695 0.13962867328120987 1.0000000000000041e-14 13.999999999999998 -2.4854014119518557 FAAK(ub)GEGQLGPAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAAKGEGQLGPAER 14 1 P13639 P13639 EEF2 Elongation factor 2 1 245927300.0 117271700.0 77746400.0 50909200.0 True False 153744334.36075842 66146940.17309354 45641604.339529306 1.0 0.4302398553294386 0.2968669026361132 27.195958005711805 -13.99999999999998 0.20399527934350678 4.216520136101109 0.21358016549741599 0.9994875356680873 0.006902781657363779 12.612755106659302 0.14319431904177285 16.21509470332529 0.08246300760935864 1.000000000000045e-14 13.99999999999998 -4.002939970603693 FAAK(ub)GEGQLGPAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAAKGEGQLGPAER 14 1 P13639 P13639 EEF2 Elongation factor 2 1 301207000.0 106267300.0 85081800.0 109857900.0 True False 102893902.72927906 119055406.43572567 81082820.32364406 1.0 1.1570695957462964 0.7880235677033123 26.616582252867634 -6.791043606739137 1.4920166699046065 1.0876655356962723 0.7839764567509463 0.8047484965201501 0.06681876588126401 0.23378863587212836 1.028099084914626 0.03524738100875547 0.08246558957597792 1.617917577250863e-07 6.791043606739137 -0.30368907894532604 FAAK(ub)GEGQLGPAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAAKGEGQLGPAER 14 1 P13639 P13639 EEF2 Elongation factor 2 1 903830000.0 347607000.0 231490000.0 324733000.0 True False 527345232.4756991 190178800.86037466 260549380.2144696 1.0 0.36063434188558513 0.4940774357459961 28.9741725067547 -9.87145226598732 6.7166069088124845 1.0000000150616788 0.4273558888175426 0.9608666527599042 0.05447791494278455 1.226213032184601e-08 2.1064387103581236e-09 0.05274801589935967 0.01758267144244975 1.3444595302837844e-10 9.87145226598732 -0.5726441262441362 FAAK(ub)GEGQLGPAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAAKGEGQLGPAER 14 1 P13639 P13639 EEF2 Elongation factor 2 1 263235600.0 117271700.0 81976600.0 63987300.0 True False 160630216.63853014 78354602.75163516 48874817.59980979 1.0 0.48779491425301585 0.3042691382891795 27.259168067234697 -13.999999999999998 0.14289920483831403 3.453705996957338 0.08488814044866418 0.999591632527947 0.0059493963384330845 11.938087721707287 0.11864059766279389 8.155771424415887 0.1965309997899523 1.0000000000000041e-14 13.999999999999998 -3.3688178565086737 FAAK(ub)GEGQLGPAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAAKGEGQLGPAER 14 1 P13639 P13639 EEF2 Elongation factor 2 1 350749800.0 106267300.0 185264000.0 59218500.0 True False 88365968.389607 184265946.0599753 71600814.55459234 1.0 2.0852591718063196 0.810275899867958 26.39698752830191 -6.681213412990462 1.8974151714774272 1.6858975905543019 0.8150616026320237 0.3297665326397542 0.45983541512702436 0.43582767044694515 3.034618514422647 0.19438119298516746 0.5119019817922537 2.0834668126391883e-07 6.681213412990462 -0.8708359879222782 FAAK(ub)GEGQLGPAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAAKGEGQLGPAER 14 1 P13639 P13639 EEF2 Elongation factor 2 1 1006524000.0 347607000.0 270031000.0 388886000.0 True False 449984113.8583546 255003537.47367382 318112738.30732214 1.0 0.566694533474005 0.7069421530900027 28.74529882884715 -10.92426009455649 11.339967894066719 1.0502615421129358 0.6368183432820038 0.8994084670945366 0.05725585094985722 0.03044790030513566 0.0002033618755784981 0.02320028546214862 0.01847924643347758 1.1905287988697911e-11 10.92426009455649 -0.41344319883093195 FAANPNQNK(ub)NVALLSQLYHSPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAANPNQNKNVALLSQLYHSPAR 23 1 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 1 57316000.0 18284000.0 26877000.0 12155000.0 True False 23970501.062507845 22867056.365725454 10897317.198993064 1.0 0.9539665568982083 0.4546136591211066 24.514756730596993 -6.924902486656761 0.7875068981726718 1.0091960437833025 0.3642477851718839 0.9954380567907739 0.016680445747323098 0.09537234331133344 0.09128875529019898 0.014758682650737973 0.04651327550990309 1.188769115096295e-07 6.924902486656761 -0.6449482586114186 down FAANPNQNK(ub)NVALLSQLYHSPAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAANPNQNKNVALLSQLYHSPAR 23 1 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 1 90725000.0 34687000.0 30385000.0 25653000.0 True False 33585880.17170388 42517888.955681756 18933709.726496145 1.0 1.2659453537711092 0.563740167883044 25.001351501749475 -6.804064252744785 1.4390854959715143 1.1459850552518742 0.5530248608992435 0.843838295086137 0.11439116741690725 0.21499858407863062 0.8785418822769533 0.06251943214664814 0.145063998031901 1.570130490405783e-07 6.804064252744785 -0.5929601943526307 FAANPNQNK(ub)NVALLSQLYHSPAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAANPNQNKNVALLSQLYHSPAR 23 1 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 1 167276700.0 44752800.0 46723000.0 75800900.0 True False 67893269.46792923 38384915.601534836 60818818.8902853 1.0 0.5653714411215199 0.8958004138983807 26.016765225625196 -9.764073395458555 5.992329433345195 1.0000000105764744 0.7305859275091201 0.4698858950407082 0.1348970632588379 1.9135881971661992e-08 3.897569341195528e-09 0.1306135257010208 0.043537839954048085 1.7215776050090462e-10 9.764073395458555 -0.26941408306735426 FAANPNQNK(ub)NVALLSQLYHSPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAANPNQNKNVALLSQLYHSPAR 23 1 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 1 54875000.0 18284000.0 22458000.0 14133000.0 True False 25044088.906521175 21465731.30132531 10795076.478271656 1.0 0.8571176768077954 0.4310428907422042 24.577966792119884 -6.951585771749891 0.541153112607966 1.0062257783143282 0.26221967424865894 0.999319933031346 0.006302456748513186 0.08285513050021923 0.033374717176021904 0.006921061477310623 0.03529158873242542 1.1179290154300954e-07 6.951585771749891 -0.7440061040656694 down FAANPNQNK(ub)NVALLSQLYHSPAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAANPNQNKNVALLSQLYHSPAR 23 1 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 1 96244200.0 34687000.0 47287200.0 14270000.0 True False 28843777.39464824 47032454.46782565 17253791.02297478 1.0 1.6305927557377486 0.5981807024407317 24.78175677718375 -6.741430805644445 1.6817609056086211 1.3745819286110281 0.5974198198841424 0.6112333656625488 0.2649398770444486 0.3152267396624317 1.751181566273682 0.12460818711257908 0.3052625275160223 1.8137156247107297e-07 6.741430805644445 -0.7771621087268857 FAANPNQNK(ub)NVALLSQLYHSPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAANPNQNKNVALLSQLYHSPAR 23 1 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 1 180183100.0 44752800.0 69364600.0 66065700.0 True False 57933381.809572816 65504399.03361619 54042420.491326675 1.0 1.130684883008027 0.9328373176791968 25.787891547717646 -6.728561114984899 1.7282739848156836 1.0787710213942203 0.9329814601110109 0.552647993432053 0.054943445498200565 0.33895440937005805 1.9827435241211275 0.02519881241407511 0.06263609518334749 1.8682667516760172e-07 6.728561114984899 -0.1457895612832094 FAASGGFLHHMAGLSSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAASGGFLHHMAGLSSSK 18 0 Q8WUT1;F8WCX5;F6VRR5;Q9BY77-2;Q9BY77 Q8WUT1 POLDIP3 Polymerase delta-interacting protein 3 0 32467100.0 11286500.0 8726200.0 12454400.0 False True 14796710.798621481 7424284.974461191 11165738.15904068 1.0 0.5017523877774827 0.7546094744300148 23.818773175072337 -10.271365942966671 4.900300534566214 1.0000999544220337 0.6281809311034493 0.74247031304948 0.10322847335869371 0.00011275767339349222 1.676605981000347e-05 0.09997727991706197 0.033316846514226 5.3534537746357444e-11 10.271365942966671 -0.3719190233185844 FAASGGFLHHMAGLSSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAASGGFLHHMAGLSSSK 18 0 Q8WUT1;F8WCX5;F6VRR5;Q9BY77-2;Q9BY77 Q8WUT1 POLDIP3 Polymerase delta-interacting protein 3 0 30566700.0 11403100.0 2297300.0 16866300.0 False True 11041114.832241355 3214623.8702612347 12448510.051845858 1.0 0.29115029769223616 1.1274685791234362 23.396382514021848 -6.682078999169286 1.8941909958498175 0.552345300967568 1.1243618662957118 0.333761519387863 0.30029146559328324 0.4339428805233379 3.011927986308609 0.12711577248846284 0.334407025673794 2.0793184198780193e-07 6.682078999169286 0.5720165653281438 FAASGGFLHHMAGLSSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAASGGFLHHMAGLSSSK 18 0 Q8WUT1;F8WCX5;F6VRR5;Q9BY77-2;Q9BY77 Q8WUT1 POLDIP3 Polymerase delta-interacting protein 3 0 36043900.0 11286500.0 10560800.0 14196600.0 False True 15459424.056194028 10094188.936104558 10843655.468154768 1.0 0.6529472831208214 0.7014268726143204 23.88198323659523 -10.122949509990722 5.01033882747474 1.0000130205934343 0.6771870778668946 0.9833661567945566 0.019791709536153085 27616088.15793627 1.021136339995024 4148.355241396085 0.00677522860237626 7.534431520916482e-11 10.122949509990722 -0.32282594272653975 FAASGGFLHHMAGLSSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAASGGFLHHMAGLSSSK 18 0 Q8WUT1;F8WCX5;F6VRR5;Q9BY77-2;Q9BY77 Q8WUT1 POLDIP3 Polymerase delta-interacting protein 3 0 21561100.0 11403100.0 5213600.0 4944400.0 False True 9482182.892983329 5185513.301981422 5978251.179677401 1.0 0.5468691503323168 0.6304720386801668 23.176787789456125 -10.835664718124137 7.366588287650836 1.0253279123797634 0.5886705945062427 0.9699480405673511 0.03413073624585098 0.012724789057810697 0.0002838667169421667 0.029618876768592286 0.01101564775616489 1.4599409216822548e-11 10.835664718124137 -0.4366573178735207 FAAYFQQGDMESNGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 FAAYFQQGDMESNGK 15 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 155094900.0 41514000.0 45700700.0 67880200.0 False True 54425256.02214794 38882333.69993335 60856608.05685637 1.0 0.714417102312031 1.1181685214689894 25.697772953230704 -6.716687111392286 1.7711602640573147 0.8256409087635128 1.117427293095538 0.49682575103783166 0.12022615683133145 0.36181885181804374 2.2163523621838097 0.053934900825433896 0.13593108788010963 1.9200515487012932e-07 6.716687111392286 0.2917863843320252 FAAYFQQGDMESNGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 FAAYFQQGDMESNGK 15 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 95339800.0 25806500.0 15014300.0 54519000.0 False True 24987286.78326392 21009588.28854015 40238838.3650584 1.0 0.840811108095659 1.6103724551642686 24.574690920704594 -6.852755445436652 1.2216754926453748 0.9148050431127702 1.6428189304229173 0.9442249535502749 0.07833262813585753 0.154452434075329 0.4422052472495321 0.05013439551978927 0.1162402135172491 1.4036038622004666e-07 6.852755445436652 0.728013887310147 FAAYFQQGDMESNGK ddPTM_RPMI8226_Bortezomib_8h_R1 2 FAAYFQQGDMESNGK 15 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 128323000.0 19895500.0 85320000.0 23107500.0 False True 30182928.055880006 70093979.39179736 18540292.49662297 1.0 2.322305485472679 0.6142642112885098 24.847229433190478 -6.7000139334251685 1.830895055897791 1.8210830991667775 0.6193536442315196 0.4176420145054972 0.5581589302332054 0.395475998760507 2.5773916309482603 0.24321152218180767 0.6254476285770826 1.9951983022002292e-07 6.7000139334251685 -1.2017294549352577 FAAYFQQGDMESNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FAAYFQQGDMESNGK 15 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 138135700.0 41514000.0 47286700.0 49335000.0 False True 56862847.67366672 45197417.23779401 37683089.08621895 1.0 0.7948496968913678 0.66270140571363 25.760983014753595 -9.393290654389785 0.06679964351819755 1.780937916488205 4.18720324001445e-13 0.9999896553319905 0.0004462982948419913 0.8584425684121874 0.025345182982541747 0.3920613043895382 0.27829138450409957 4.0430521725170154e-10 9.393290654389785 -1.7809379164877863 FAAYFQQGDMESNGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FAAYFQQGDMESNGK 15 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 70023500.0 25806500.0 27215400.0 17001600.0 False True 21459248.171793155 27068785.238366056 20556555.95348339 1.0 1.2614041750980953 0.9579345832117131 24.35509619613887 -6.678820396957741 1.9063569182065734 1.1655744753435215 0.9591090303732878 0.3185512547917475 0.11081910973026357 0.44118428699306916 3.0989686558100065 0.04666564483627496 0.12325124878528426 2.0949786578508578e-07 6.678820396957741 -0.20646544497023378 FAAYFQQGDMESNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FAAYFQQGDMESNGK 15 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 85000600.0 19895500.0 42284400.0 22820700.0 False True 25755116.948936302 39931235.96902506 18667566.760155722 1.0 1.5504195165642312 0.7248100172547149 24.618355755282927 -6.726957022977165 1.7339158153906 1.3323419779758248 0.7255278580174451 0.5453334178583755 0.23144307623413016 0.34194768526604136 2.0125299627107056 0.10583074615210226 0.2635624552683958 1.8751800634276408e-07 6.726957022977165 -0.6068141199583796 FAAYFQQGDMESNGK(ub)YITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAAYFQQGDMESNGKYITK 19 1 P06744;A0A2U3TZU2;P06744-2;K7EQ48;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 1 39286500.0 3090900.0 4216600.0 31979000.0 True False 4001230.980747764 3981942.503310709 26159150.132249203 1.0 0.9951793641682114 6.537775564099149 21.932012483476512 -6.906697294243273 0.9179134032042517 0.8099550824865643 7.205722649466004 0.9896148649667412 0.26614865542878796 0.10664328744435442 0.1509064785453846 0.21440202059282595 0.579154340163934 1.2396603358745367e-07 6.906697294243273 6.39576756697944 up FACAVVCIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FACAVVCIQK 10 0 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 40122200.0 9264200.0 18139000.0 12719000.0 False True 12145455.914640414 15432731.905268213 11402959.889263093 1.0 1.2706589208121237 0.9388663521076802 23.533913310911988 -6.689901732323293 1.8676904196769466 1.1697108149586446 0.9400433501197699 0.36959117394334995 0.11447309693128423 0.41685507052342674 2.819410627454692 0.04904408448395456 0.1276864661485321 2.042199980346605e-07 6.689901732323293 -0.22966746483887468 FACAVVCIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FACAVVCIQK 10 0 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 41420000.0 9264200.0 8607800.0 23548000.0 False True 12689425.095591424 8227478.933811911 17986447.386283256 1.0 0.6483728673153453 1.417435955592041 23.59712337243488 -6.782393834161515 1.5265646147118488 0.8015191164477792 1.4239894351141005 0.7757630223479632 0.148857017710211 0.24687252473375118 1.1364868763181923 0.07679047789575029 0.1808325575377279 1.6504644177362906e-07 6.782393834161515 0.6224703186663213 FACHSASLTVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FACHSASLTVR 11 0 Q15233;Q15233-2;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 458751000.0 219470000.0 170720000.0 68561000.0 False True 287727295.3505035 145249241.46134785 61466965.403551124 1.0 0.504815649430855 0.21362924684873336 28.100126848437853 -8.632960764975037 0.25044712309870326 1.254535378309828 1.1461274757838195e-11 0.9992878350463671 0.008662818806206233 0.227722268171879 0.0710043513586094 0.1580240398800353 0.11170857106828383 2.3283015915480823e-09 8.632960764975037 -1.2545353782983668 down FACHSASLTVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FACHSASLTVR 11 0 Q15233;Q15233-2;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 269022000.0 135420000.0 40531000.0 93071000.0 False True 131121166.22516039 56715239.66637271 68692913.02984932 1.0 0.43254068964717474 0.5238888198408052 26.966325350404347 -10.798539793526139 7.224040994641243 1.018286685837772 0.47821475474399 0.9775297960767124 0.03729271798862001 0.01040562765527621 0.00029018625054412007 0.03420872140215675 0.012036172975394575 1.5902309674953013e-11 10.798539793526139 -0.5400719310937819 FACHSASLTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FACHSASLTVR 11 0 Q15233;Q15233-2;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 607070000.0 171390000.0 193810000.0 241870000.0 False True 260011160.28736535 159223091.25555834 194064288.48461282 1.0 0.6123702193382174 0.7463690722741755 27.95399830752835 -10.37937624203376 5.25169484364597 1.0001764729092102 0.6793696458061845 0.8841773386401801 0.054704802635265296 0.0001130945222716518 1.3365099718148125e-05 0.05299660626615608 0.0176558991303228 4.174685447093806e-11 10.37937624203376 -0.32080682710302566 FACHSASLTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FACHSASLTVR 11 0 Q15233;Q15233-2;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 504880000.0 219470000.0 135150000.0 150260000.0 False True 300613989.9537416 129178626.11871554 114771682.70183964 1.0 0.42971594947591596 0.381790889770302 28.163336909960744 -13.999999999999998 0.3508096532079084 8.048335660356114 0.3752404330105215 0.9997562487726332 0.0043841980066610785 20.74080331527622 0.1907227255786403 108.98089971349137 0.014259727978045963 1.0000000000000041e-14 13.999999999999998 -7.673095227345593 FACHSASLTVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FACHSASLTVR 11 0 Q15233;Q15233-2;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 286692000.0 135420000.0 69674000.0 81598000.0 False True 112607730.12319493 69298652.33279377 98659764.53347564 1.0 0.6153987142532734 0.876136695283175 26.746730625838623 -9.960027366461784 5.298605617834794 1.000000784920876 0.7457677047670035 0.5590104198816652 0.10644583501872958 9.870164708369432e-07 1.9391063348308625e-07 0.10306605447471298 0.03435524552444019 1.0964091052739578e-10 9.960027366461784 -0.2542330801538726 FACHSASLTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FACHSASLTVR 11 0 Q15233;Q15233-2;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 835940000.0 171390000.0 423810000.0 240740000.0 False True 221867733.60198012 400224600.941069 196927790.20099646 1.0 1.8038882646137828 0.8875909398987926 27.7251246296208 -6.674991238977308 1.919851669104521 1.510910409931144 0.8912187880391222 0.3012405352473181 0.3410884765744992 0.44977317134558 3.2006781568386544 0.14279613624971021 0.37902594282269936 2.1135316756816228e-07 6.674991238977308 -0.6196916218920216 FACNGTVIEHPEYGEVIQLQGDQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FACNGTVIEHPEYGEVIQLQGDQR 24 0 P41567;K7EM18;O60739;K7EQP2 P41567 EIF1;EIF1B Eukaryotic translation initiation factor 1;Eukaryotic translation initiation factor 1b 0 15905900.0 2204500.0 8105900.0 5595500.0 False True 2890120.848408369 6896531.316550722 5016531.335826056 1.0 2.386243232821472 1.7357514093532567 21.462698388608707 -10.117829873940469 4.939133868408452 0.9999533819527623 2.060997321091702 0.7800836383332995 0.26556217490663114 92590276.79837973 3.1874063711444425 49089.60562479521 0.09090899600803452 7.623775975081644e-11 10.117829873940469 1.0610439391389397 FACNGTVIEHPEYGEVIQLQGDQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FACNGTVIEHPEYGEVIQLQGDQR 24 0 P41567;K7EM18;O60739;K7EQP2 P41567 EIF1;EIF1B Eukaryotic translation initiation factor 1;Eukaryotic translation initiation factor 1b 0 14518100.0 7426100.0 1937300.0 5154700.0 False True 7190362.520341629 2710873.992886038 3804529.43231473 1.0 0.3770149259118633 0.5291151067212072 22.77763307894765 -10.294570411721041 8.548058953206963 1.0000005103663008 0.4530650163173106 0.9451770394461677 0.06209463879465911 6.039651949997363e-07 4.97836541198107e-08 0.060122931920780366 0.020040958495039986 5.074924531252187e-11 10.294570411721041 -0.5469354940489901 FACNGTVIEHPEYGEVIQLQGDQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FACNGTVIEHPEYGEVIQLQGDQR 24 0 P41567;K7EM18;O60739;K7EQP2 P41567 EIF1;EIF1B Eukaryotic translation initiation factor 1;Eukaryotic translation initiation factor 1b 0 20043500.0 2204500.0 9504100.0 8334900.0 False True 3019563.224372457 9084177.436144166 6366368.282653826 1.0 3.008440877416002 2.1083738970151624 21.5259084501316 -10.600096908985442 7.31130185103179 0.99814275840237 2.5584073872155684 0.7998861662585525 0.36745080605161395 0.011126440979644011 0.0006085770203190198 0.35585782559719 0.1185942376990327 2.5113259887252826e-11 10.600096908985442 1.5602646288131985 FADMECK(ub)LGEIDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FADMECKLGEIDR 13 1 Q9HCS7 Q9HCS7 XAB2 Pre-mRNA-splicing factor SYF1 1 3792520.0 1148600.0 929720.0 1714200.0 True False 1573268.4597478819 888641.896227098 1309341.2650571908 1.0 0.5648380546378613 0.8322427472212939 20.58533344001452 -10.345547212646592 6.022845222802926 1.0000344795249307 0.6985404009295776 0.6288829543787198 0.10916750860920209 5.054836693864352e-05 5.492819165497271e-06 0.10571305092678449 0.03523366189919943 4.5128696275568656e-11 10.345547212646592 -0.30149407859535315 FAEALGSTEAK(ub)AVPYQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAEALGSTEAKAVPYQK 17 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 13050700.0 4324300.0 4850600.0 3875800.0 True False 5669199.176580771 4126909.387490708 3474769.3952988395 1.0 0.7279527952623011 0.6129206766368289 22.43471352573103 -13.999999999897293 0.11776465841718727 2.299063333261112 0.42366823814937776 0.9997039765882738 0.002792424319545998 11.972896449538608 0.1053182868183423 3.6513546966111083 0.167929184197184 1.000000000236492e-14 13.999999999897293 -1.8753950951117342 FAEALGSTEAK(ub)AVPYQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAEALGSTEAKAVPYQK 17 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 13292600.0 4464000.0 3871000.0 4957600.0 True False 4322292.763470059 5416710.486998316 3659055.835187988 1.0 1.2532030529671079 0.8465543718168674 22.04336536343318 -6.738323029008635 1.6927946839220034 1.1509479496049062 0.8464009114434745 0.5973836059012443 0.10639037124556151 0.3208713296254514 1.8047295515203812 0.04973252937878755 0.12226647190507788 1.826740977512885e-07 6.738323029008635 -0.3045470381614317 FAEALGSTEAK(ub)AVPYQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAEALGSTEAKAVPYQK 17 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 11052700.0 4324300.0 2520500.0 4207900.0 True False 5923110.56981348 2409135.975821107 3214080.68442081 1.0 0.406734932165376 0.5426339161725326 22.497923587253922 -10.020928513749503 7.366717583114663 1.0000000322015765 0.474684424169415 0.9522048822571834 0.05548052789669784 2.931598482244162e-08 3.9117840209713e-09 0.053718793347549774 0.017906263381892187 9.529530102054739e-11 10.020928513749503 -0.5253156080321615 FAEALGSTEAK(ub)AVPYQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAEALGSTEAKAVPYQK 17 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 13025000.0 4464000.0 5008300.0 3552700.0 True False 3712013.788730924 4981319.293830283 4295553.144171159 1.0 1.341945255955882 1.1572029061992621 21.823770638867455 -10.160336034550461 4.038514500308499 0.9999060704366317 1.249574080979005 0.7087393654498032 0.07542074878112068 10334445.0780644 8701340.684054827 8041.573083018492 0.025818529598390375 6.912958750288344e-11 10.160336034550461 0.2496680105423733 FAEEK(ub)EWDSEASCPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAEEKEWDSEASCPK 15 1 H0YKR0;Q9NQS1 H0YKR0;Q9NQS1 AVEN Cell death regulator Aven 1 5121600.0 3337400.0 1784200.0 0.0 True False 4375363.719427572 1518004.3147571299 0.0 1.0 0.3469435713462766 0.0 22.060971520989927 -8.512337315055047 0.5113434410042147 1.0519735273297497 1.0417076944711513e-16 0.9935516906602845 0.033290945361100166 0.227206160913983 0.18448321583054308 0.08096775828383691 0.06647646368467075 3.073708548349196e-09 8.512337315055047 -1.0519735273297497 FAEEK(ub)EWDSEASCPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAEEKEWDSEASCPK 15 1 H0YKR0;Q9NQS1 H0YKR0;Q9NQS1 AVEN Cell death regulator Aven 1 15827200.0 4674100.0 6196700.0 4956400.0 True False 7090951.422481912 5090850.4699619105 3976765.367532705 1.0 0.7179361649300449 0.5608225371456279 22.75754778217793 -13.761927973347944 0.07124759648855922 2.5727835026302626 1.9310515841511028e-12 0.9999257573816562 0.0015655592305291511 11.339701261410054 0.06984058746426063 3.014624608289146 0.5011310998736784 1.7301032687165965e-14 13.761927973347944 -2.5727835026283317 FAEEK(ub)EWDSEASCPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAEEKEWDSEASCPK 15 1 H0YKR0;Q9NQS1 H0YKR0;Q9NQS1 AVEN Cell death regulator Aven 1 4869700.0 3337400.0 1532300.0 0.0 True False 4571326.969843787 1464597.9193615087 0.0 1.0 0.3203879155928235 0.0 22.12418158251282 -8.64406418774239 0.49930523381226183 1.065469106206422 4.301193261563629e-21 0.994387276742278 0.031236060206984616 0.29041130446645624 0.18874471270591456 0.09927727302902013 0.06345981414592751 2.2695293957818106e-09 8.64406418774239 -1.065469106206422 FAEEK(ub)EWDSEASCPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAEEKEWDSEASCPK 15 1 H0YKR0;Q9NQS1 H0YKR0;Q9NQS1 AVEN Cell death regulator Aven 1 13965000.0 4674100.0 4872600.0 4418300.0 True False 6050714.590285406 4601435.526640356 3614214.7355863773 1.0 0.7604780324671222 0.5973203134368792 22.52867410427038 -7.929340129538406 0.09513773555269082 1.5102611195197966 3.584408953887513e-07 0.9999930253095244 0.00043671313630011993 0.11815984081242326 0.014527395972044296 0.10209012749719117 0.11889689159780437 1.1766840604238701e-08 7.929340129538406 -1.5102607610789012 FAEEQLLK(ub)HGWTQGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAEEQLLKHGWTQGK 15 1 A0A0A0MRK1;E9PAV9;Q5T3I0;Q5T3I0-3;F8W895;E9PPY4;F2Z3C6 A0A0A0MRK1 GPATCH4 G patch domain-containing protein 4 1 4461000.0 1002700.0 1509200.0 1949100.0 True False 833789.4771416883 1501069.6400472533 2356647.79837983 1.0 1.8002981342401518 2.8264302476671315 19.669323639133726 -6.967733224351062 0.3075498720607431 0.8372714912505477 3.821959374760313 0.999958912623753 0.004791651040691117 0.07704531402916648 0.011649326953446958 0.01641844513128577 0.09131991749697373 1.0771266609608116e-07 6.967733224351062 2.9846878835097654 FAETQPK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAETQPKK 8 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 2236590.0 656580.0 1038300.0 541710.0 True False 860782.7383297643 883389.6872616998 485659.0456492424 1.0 1.0262632461424601 0.5642063020357494 19.715289621597446 -6.893430848119286 1.0018458013853657 1.0228236432131377 0.5216843153210569 0.9830055889843523 0.027623428271786946 0.11640439190718635 0.2059309659144172 0.020908098056553654 0.05281209669376683 1.278112704809166e-07 6.893430848119286 -0.5011393278920808 FAETQPK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAETQPKK 8 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 1927170.0 560220.0 909600.0 457350.0 True False 542436.1227489243 1272808.0235013373 337556.31479409843 1.0 2.346466192279156 0.6222968947632974 19.049093730299465 -6.698367542436225 1.8370159890036613 1.8374402261473926 0.6276313353781305 0.40973657054598134 0.5685311232098631 0.39890093480750466 2.6160188321581845 0.2470283116088479 0.636498289294719 2.002776364848023e-07 6.698367542436225 -1.2098088907692621 FAETQPK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAETQPKK 8 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 1896370.0 656580.0 724490.0 515300.0 True False 899335.3694073333 692479.6362319507 393596.7529366296 1.0 0.7699904393711307 0.437652922731163 19.778499683120337 -6.965871890075032 0.34275916740289947 1.0349138873840205 0.16163862553388852 0.9999300056839355 0.001931264817516312 0.07766632544939761 0.013823604527131822 0.004652901358982851 0.02870794501666225 1.081753004069826e-07 6.965871890075032 -0.8732752618501319 down FAETQPK(ub)KDTPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAETQPKKDTPR 12 2 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 4222650.0 1394400.0 719050.0 2109200.0 True False 2115406.744294896 590729.909536707 1692315.6955048 1.0 0.27925121782364754 0.7999954146259849 21.012503656574207 -9.980588788278201 6.570534883479905 1.0000000922648686 0.5396233162259596 0.5103121034442997 0.21259292811354988 2.873493333463441e-07 4.4348366224210275e-08 0.20584226046793208 0.06861407250876808 1.0457098809968628e-10 9.980588788278201 -0.46037677603890903 FAETQPK(ub)KDTPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAETQPKKDTPR 12 2 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 4186700.0 1394400.0 1591600.0 1200700.0 True False 1805078.287733246 1503026.0608711557 982184.9202223838 1.0 0.8326653038182643 0.5441231701123485 20.783629978666657 -6.962837962236236 0.39339806807875916 1.017063883543282 0.34930029815333186 0.9998614078698512 0.00221665002408964 0.07870249593449222 0.017496243837023504 0.0037192468404986024 0.024237386035241237 1.0893364552042609e-07 6.962837962236236 -0.6677635853899501 FAEYGEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAEYGEIK 8 0 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 13387600.0 2579200.0 5622000.0 5186400.0 False True 3381356.177008327 4783219.514384364 4649761.079461757 1.0 1.414586119885289 1.3751172121641613 21.689170560633563 -10.343751674851548 5.231847952950263 0.9998544398420274 1.3948516660247503 0.9925619140635822 0.01611311410371453 2.7367636670755434e-05 3.4328511143362984e-06 0.015607158595083426 0.005200485214922802 4.5315661616356554e-11 10.343751674851548 0.3949972261827229 FAEYGEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAEYGEIK 8 0 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 7777400.0 2579200.0 2455500.0 2742700.0 False True 3532799.940259212 2347007.8907473614 2094930.7476795919 1.0 0.6643478063960662 0.5929944472105829 21.752380622156455 -13.999999999999998 0.21762702995183156 3.0046546390880398 0.5539485902345375 0.9994956286894172 0.003985280829192266 12.936139303022141 0.1478044183333177 11.13082274461569 0.040115936762011334 1.0000000000000041e-14 13.999999999999998 -2.4507060488535024 FAEYTHK(ub)SPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAEYTHKSPR 10 1 Q9NZD8;H0YMB7;H0YKB0;Q9NZD8-2 Q9NZD8 SPG21 Maspardin 1 10963300.0 4009200.0 3920600.0 3033500.0 True False 3881930.140525127 5486116.025658907 2238935.3469506907 1.0 1.4132443982922307 0.5767582789750615 21.888342724772755 -6.772384334589291 1.5654212358551207 1.2363038409615645 0.5716337427720499 0.7395659631886158 0.17427790213952868 0.2625901962079372 1.270281094351336 0.08773736699123297 0.20838983427624194 1.688945615550121e-07 6.772384334589291 -0.6646700981895146 FAEYTHK(ub)SPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAEYTHKSPR 10 1 Q9NZD8;H0YMB7;H0YKB0;Q9NZD8-2 Q9NZD8 SPG21 Maspardin 1 19086600.0 8232600.0 0.0 10854000.0 True False 10657262.988807166 0.0 8878683.371444782 1.0 0.0 0.8331110324263984 23.345333635190165 -9.640708910245628 11.222470386797267 0.9999999999722372 0.4165555162131992 0.3953799192847005 0.3401161547546611 0.0 0.0 0.32931605078522674 0.1097720169284089 2.2871312598957857e-10 9.640708910245628 -0.583444483759038 FAFQAEVNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAFQAEVNR 9 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 272954000.0 70884000.0 121010000.0 81060000.0 False True 92929610.44163239 102955779.69328561 72672688.78242522 1.0 1.1078899309273496 0.7820186530112464 26.469635024336824 -6.8174502440573335 1.3826858459276645 1.058305734482751 0.7752750011857253 0.8784741982407603 0.047251186528092175 0.1968038062859227 0.7399671513207674 0.026858090875328373 0.061955132327212205 1.5224735485604682e-07 6.8174502440573335 -0.28303073329702555 FAFQAEVNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAFQAEVNR 9 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 499550000.0 119020000.0 218540000.0 161990000.0 False True 180562041.5275231 179539829.53918636 129972605.49726062 1.0 0.9943387215846199 0.7198224189188117 27.427919394687358 -6.911357033630027 0.8864457472618086 1.0081391076084094 0.6832967762237676 0.9914236146308937 0.01210980266770646 0.10352738086738385 0.1339513443062609 0.009981467324363502 0.02781933230896365 1.226430567648915e-07 6.911357033630027 -0.3248423313846418 FAFQAEVNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAFQAEVNR 9 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 502780000.0 119020000.0 237270000.0 146490000.0 False True 154073736.23494744 224065715.9229073 119830323.1143308 1.0 1.4542758642604012 0.7777465909673354 27.199045716779807 -6.725784048571835 1.7384155947848565 1.2746626165655073 0.7784385894269488 0.5396129733161773 0.19103967716354256 0.34424222327892295 2.0360391273154015 0.08715327116258076 0.21732023979678436 1.8802515329596045e-07 6.725784048571835 -0.4962240271385585 FAFSPLSEEEEEDEQK(ub)EPMLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAFSPLSEEEEEDEQKEPMLK 21 1 Q8NBN3-3;Q8NBN3 Q8NBN3-3 TMEM87A Transmembrane protein 87A 1 8278400.0 1751300.0 4091500.0 2435600.0 True False 2295971.2596133277 3481064.1485420833 2183587.4759249296 1.0 1.5161619005319522 0.9510517463065609 21.13067315215971 -6.666407027296761 1.9503481949560042 1.3304770350555932 0.9533786091824682 0.2631781997618796 0.2194375111582688 0.46938879598331607 3.4387737424113136 0.0906961961629063 0.24343740761045085 2.1557230861116093e-07 6.666407027296761 -0.37709842587312503 FAGASIK(ub)IAPAEGPDVSER ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAGASIKIAPAEGPDVSER 19 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 29825500.0 8813900.0 11250000.0 9761600.0 True False 11555108.25392903 9571543.852156531 8751563.27187913 1.0 0.8283387435078302 0.7573761387223158 23.462027439956067 -13.999999999999998 0.12129084427110122 1.8174480878635577 0.6460606806878373 0.9996866292667691 0.0018030531273866704 11.958993660934109 0.10734740393991177 2.352498373513068 0.09879078117149291 1.0000000000000041e-14 13.999999999999998 -1.1713874071757204 FAGASIK(ub)IAPAEGPDVSER ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAGASIKIAPAEGPDVSER 19 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 52611000.0 17253000.0 16401000.0 18957000.0 True False 16705312.958814716 22950004.830085106 13991593.002190312 1.0 1.3738147191055956 0.8375534799428894 23.993803674714453 -6.71928763215149 1.7621045167242715 1.2275988718998625 0.8384351873413124 0.5090707300415942 0.15731631402449744 0.35669362134316546 2.1641535147780813 0.07090182238398626 0.17812420521852526 1.9085887862941722e-07 6.71928763215149 -0.3891636845585501 FAGASIK(ub)IAPAEGPDVSER ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAGASIKIAPAEGPDVSER 19 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 124009600.0 29459700.0 33441000.0 61108900.0 True False 44692518.692559 27473192.274274446 49030699.13001762 1.0 0.6147156857115897 1.097067262359973 25.413530015788762 -6.6939489874000015 1.8521916264775236 0.7593540876174444 1.095493219718769 0.3890555598548866 0.16281945764585873 0.4082363726172397 2.718240280752664 0.07024188410296299 0.18202243253715975 2.023256818191638e-07 6.6939489874000015 0.3361391321013246 FAGASIK(ub)IAPAEGPDVSER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAGASIKIAPAEGPDVSER 19 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 38319900.0 8813900.0 18876000.0 10630000.0 True False 12072637.016691504 18041995.905415285 8119412.931722053 1.0 1.4944536045000447 0.6725467617800681 23.52523750147896 -6.743811761184186 1.6728413828605466 1.2928916535211326 0.6716621912146767 0.6218992125893539 0.20773930603009583 0.3109570270666723 1.710009328831692 0.09818758211266862 0.239933402655253 1.8037994028489005e-07 6.743811761184186 -0.6212294623064558 FAGASIK(ub)IAPAEGPDVSER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAGASIKIAPAEGPDVSER 19 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 45614000.0 17253000.0 17554000.0 10807000.0 True False 14346633.93749431 17459433.117803805 13066693.73407766 1.0 1.216970698065581 0.9107846335946733 23.77420895014873 -6.716363513460771 1.7723935381338916 1.132513805424571 0.9113568805477519 0.4952751947726123 0.09134535714433437 0.3624473298630387 2.223126868427083 0.04095369945914882 0.10325169757824319 1.9214827348460464e-07 6.716363513460771 -0.22115692487681904 FAGASIK(ub)IAPAEGPDVSER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAGASIKIAPAEGPDVSER 19 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 118592100.0 29459700.0 45705400.0 43427000.0 True False 38136162.38750362 43161854.31172444 35523731.598648705 1.0 1.1317828436210884 0.9314972817057505 25.18465633788121 -6.729216674351102 1.7259002189892028 1.0793751970611072 0.9316295388097063 0.5556890273817238 0.055401998785253224 0.3377206850427723 1.9704112943861114 0.025440975238441257 0.06319060140759233 1.865448765476282e-07 6.729216674351102 -0.14774565825140085 FAGGLHFSGPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAGGLHFSGPK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 238613000.0 69770000.0 72648000.0 96195000.0 False True 91469145.65364116 61809201.57968606 86241664.16759671 1.0 0.6757382627551151 0.9428497834030403 26.44678184018457 -9.990722720776258 6.489867631803488 1.0000000537386597 0.8092940242560156 0.40463608684673946 0.1090478216677277 8.472437208174465e-08 1.3212459068225063e-08 0.10558512920823093 0.03519503310494078 1.021591519843867e-10 9.990722720776258 -0.19070602948264415 FAGGLHFSGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAGGLHFSGPK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 150182800.0 47849000.0 16693800.0 85640000.0 False True 46330059.68621838 23359721.39701694 63208314.85507077 1.0 0.504202272892078 1.3643046282082192 25.465445205183105 -6.750397496782115 1.648378286996257 0.7086043802186771 1.3660651764882974 0.6506723835146424 0.20834168664490646 0.29935535522720347 1.6004745482470366 0.09983922466445198 0.24228113411938704 1.7766525485723116e-07 6.750397496782115 0.6574607962696203 FAGGLHFSGPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAGGLHFSGPK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 108012900.0 30046000.0 37022800.0 40944100.0 False True 45581978.656830445 30415792.07954328 32851480.688563496 1.0 0.6672766952161583 0.7207120370067724 25.441960215766013 -10.425472931451374 5.969436927572777 1.000113795823628 0.6939943661114817 0.9776416712754803 0.021814886936370854 3.305028119692021e-05 3.1808946907601108e-06 0.02112997635099632 0.007040724483663444 3.7542835330483685e-11 10.425472931451374 -0.30611942971214623 FAGGLHFSGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAGGLHFSGPK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 182562000.0 69770000.0 58365000.0 54427000.0 False True 95565854.46335512 55786241.312755 41572463.559250824 1.0 0.5837465863306472 0.43501377968834937 26.509991901707462 -13.999999999999986 0.143309011470979 2.9949484230387626 0.2580857074614929 0.9995900772365499 0.004841315761246385 11.938828059863622 0.11883747259923397 6.649068663244444 0.1585492190818321 1.0000000000000327e-14 13.999999999999986 -2.73686271557727 FAGGLHFSGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAGGLHFSGPK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 108341900.0 47849000.0 30219500.0 30273400.0 False True 39788563.570113346 30056701.555398896 36603427.97161347 1.0 0.7554105717446807 0.9199484647670882 25.24585048061738 -10.111155511053758 4.716650945880873 1.00001042327306 0.8376795184316481 0.5647704073012585 0.0671723135502309 93618758.7633311 2.139899983021774 10597.82009166216 0.02299486960594649 7.741845301536993e-11 10.111155511053758 -0.16233090484141188 FAGGLHFSGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAGGLHFSGPK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 170986000.0 30046000.0 84970000.0 55970000.0 False True 38895139.29520442 80241344.80536698 45784034.300696984 1.0 2.0630172885191422 1.1771145477384093 25.213086537858462 -10.280702287412332 4.374252008220146 0.9995573623382452 1.6200659181366943 0.3951104133489661 0.3616682794677339 256256557.36002606 837.6386123622947 1142465.020382944 0.12380867187005558 5.239594922241775e-11 10.280702287412332 0.6205085557984491 FAGLHFFNPVPVMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 FAGLHFFNPVPVMK 14 0 A0A0D9SFP2;E9PF18;Q16836;Q16836-3;Q16836-2;A0A1W2PQV5;A0A1W2PNM1;A0A0A0MSE2;A0A1W2PQC2;A0A1W2PRT2 A0A0D9SFP2 HADH Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 0 221123380.0 56380310.0 61586870.0 103156200.0 False True 73915132.39769876 52398349.05973902 92482585.9681423 1.0 0.7088988054274306 1.2511996254101496 26.139366416948672 -6.760912305511778 1.6091873265885621 0.8311030050556485 1.253260296424765 0.6946263692624202 0.12245369945802258 0.2813860194833867 1.4363162560807494 0.060036808440665404 0.14413951143064915 1.734154129778385e-07 6.760912305511778 0.4221572913691165 FAGLHFFNPVPVMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 FAGLHFFNPVPVMK 14 0 A0A0D9SFP2;E9PF18;Q16836;Q16836-3;Q16836-2;A0A1W2PQV5;A0A1W2PNM1;A0A0A0MSE2;A0A1W2PQC2;A0A1W2PRT2 A0A0D9SFP2 HADH Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 0 298948400.0 117308300.0 53460600.0 128179500.0 False True 113584412.22781691 74807696.373346 94605443.64742574 1.0 0.6586088258598704 0.8329086869567548 26.759189619076565 -10.516588827199119 7.174799745342937 1.0000864696369842 0.7457587564083413 0.7393696623486544 0.07115762032089186 9.845722971822255e-05 6.633622154718463e-06 0.06892136209281556 0.022966023204880382 3.043765378370578e-11 10.516588827199119 -0.2543277132286429 FAGLHFFNPVPVMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAGLHFFNPVPVMK 14 0 A0A0D9SFP2;E9PF18;Q16836;Q16836-3;Q16836-2;A0A1W2PQV5;A0A1W2PNM1;A0A0A0MSE2;A0A1W2PQC2;A0A1W2PRT2 A0A0D9SFP2 HADH Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 0 30452900.0 13249900.0 0.0 17203000.0 False True 20101066.997441847 0.0 13802819.50965725 1.0 0.0 0.6866709867398512 24.26076874825562 -10.46475764696892 8.209516586754507 1.0000265010184364 0.34333549627660015 0.5494176471676396 0.28033225644767823 0.00013597937112362602 8.865429261244974e-06 0.271441428827701 0.0904768467188837 3.4295911753994766e-11 10.46475764696892 -0.6566910047418362 FAGLHFFNPVPVMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FAGLHFFNPVPVMK 14 0 A0A0D9SFP2;E9PF18;Q16836;Q16836-3;Q16836-2;A0A1W2PQV5;A0A1W2PNM1;A0A0A0MSE2;A0A1W2PQC2;A0A1W2PRT2 A0A0D9SFP2 HADH Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 0 275743610.0 56380310.0 89183700.0 130179600.0 False True 77225634.22758846 85243269.24294251 99433859.61302026 1.0 1.103820902159581 1.287575823851221 26.202576478471563 -6.962362718897636 0.4007491233953493 0.9899818418121706 1.4081325820217216 0.999848033680803 0.0014657792457166902 0.0788676962412533 0.018090409352680564 0.0023641783969256145 0.015391369513592339 1.0905291557224871e-07 6.962362718897636 0.418150740209551 FAGLHFFNPVPVMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FAGLHFFNPVPVMK 14 0 A0A0D9SFP2;E9PF18;Q16836;Q16836-3;Q16836-2;A0A1W2PQV5;A0A1W2PNM1;A0A0A0MSE2;A0A1W2PQC2;A0A1W2PRT2 A0A0D9SFP2 HADH Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 0 226140300.0 117308300.0 48538800.0 60293200.0 False True 97547049.08884045 48277311.850202516 72900229.35574092 1.0 0.4949130937444782 0.7473340304671587 26.53959489451084 -10.124767343037053 5.370376120903955 1.0000075538609652 0.6211235621056486 0.7502425251640468 0.1030504158949219 9.320425230127332e-06 1.5190199878015013e-06 0.09978012388650162 0.03325937871497822 7.502960446245496e-11 10.124767343037053 -0.3788839917553166 FAGLHFFNPVPVMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAGLHFFNPVPVMK 14 0 A0A0D9SFP2;E9PF18;Q16836;Q16836-3;Q16836-2;A0A1W2PQV5;A0A1W2PNM1;A0A0A0MSE2;A0A1W2PQC2;A0A1W2PRT2 A0A0D9SFP2 HADH Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 0 70338900.0 13249900.0 31127900.0 25961100.0 False True 17152256.744575955 29395605.0013768 21236446.183380824 1.0 1.7138039290761287 1.238113823715728 24.03189507034807 -10.17854555991944 4.022628954065446 0.999777071139623 1.475958876267401 0.5717052095716243 0.19419967278865127 137307961.24257556 269965066.57634485 419155.78244182136 0.07106981036743318 6.629098010781305e-11 10.17854555991944 0.47618180512777797 FAHIDGDHLTLLNVYHAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAHIDGDHLTLLNVYHAFK 19 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 25298000.0 8637000.0 7860300.0 8800700.0 False True 11323190.64082697 6687573.87920942 7890087.986275474 1.0 0.5906086094759069 0.6968078376978765 23.43277720127755 -10.053566051175967 7.23670118009774 1.0000000504366373 0.6437082235868954 0.9375291823586925 0.043355653370200906 3.530996963412251e-08 4.581280087138096e-09 0.041978937122000966 0.013992976955560777 8.83962718454055e-11 10.053566051175967 -0.3562918268497419 FAHIDGDHLTLLNVYHAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAHIDGDHLTLLNVYHAFK 19 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 71942400.0 21520600.0 25557200.0 24864600.0 False True 20837440.332780868 35762323.23903736 18351815.337989166 1.0 1.716253180232367 0.8807135159071632 24.312674732326677 -6.679795391002691 1.90252241410939 1.4532792338007485 0.8838982920212091 0.3230994638627688 0.30358169279525266 0.4390545448924367 3.0723578188423386 0.12804382265267664 0.33780691309830013 2.09028069207083e-07 6.679795391002691 -0.5693809417795395 FAHIDGDHLTLLNVYHAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAHIDGDHLTLLNVYHAFK 19 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 77362600.0 8637000.0 33843000.0 34882600.0 False True 11830332.306148734 32347704.356164962 26644048.309697803 1.0 2.734302259569874 2.2521808872477522 23.49598726280044 -10.488177807320643 5.919261946246205 0.998605172847825 2.493241573408812 0.9274860948898651 0.19682522604659894 0.0036250827984191073 0.0003134506213535122 0.19068379707092664 0.06352506854933217 3.249542285286667e-11 10.488177807320643 1.494636400560987 FAHIDGDHLTLLNVYHAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAHIDGDHLTLLNVYHAFK 19 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 43022000.0 21520600.0 6660400.0 14841000.0 False True 17895332.42423001 6624519.103214107 17944184.482969075 1.0 0.37018139401783945 1.0027298771311406 24.093080007760953 -10.904628644363239 11.018623846524818 1.0278893187022562 0.6864556355745026 0.24676330010419345 0.2582368368665149 0.12842625352882547 0.0011115873844766114 0.18149811261982773 0.0833455807134411 1.245579223876905e-11 10.904628644363239 -0.3414336831277536 FAIATK(ub)EGDLPQVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAIATKEGDLPQVER 15 1 J3KNI1;Q9H9E3;A0A6I8PIQ6;A0A0A0MS45;Q9H9E3-3;Q9H9E3-2;J3KRB5 J3KNI1 COG4 Conserved oligomeric Golgi complex subunit 4 1 4471000.0 891500.0 1593300.0 1986200.0 True False 1168765.1332982816 1355585.8506347556 1780687.0769757316 1.0 1.1598445333574092 1.5235627982421007 20.156553614617955 -6.957445334673839 0.47005592600979273 0.9903984180449436 1.7079209876259476 0.9996634010590829 0.0040193521834563485 0.08062663371032665 0.024601253593236245 0.005029525553763027 0.03001954224520724 1.1029470547845975e-07 6.957445334673839 0.717522569581004 FAIATK(ub)EGDLPQVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAIATKEGDLPQVER 15 1 J3KNI1;Q9H9E3;A0A6I8PIQ6;A0A0A0MS45;Q9H9E3-3;Q9H9E3-2;J3KRB5 J3KNI1 COG4 Conserved oligomeric Golgi complex subunit 4 1 37974100.0 3214900.0 7833200.0 26926000.0 True False 4877238.34067244 6435304.25892905 21604064.29791496 1.0 1.3194565878119038 4.429569110402823 22.21763304497955 -6.926637009147602 0.773900071507919 0.9463429189383007 5.016611277323011 0.9958349677777396 0.09983400217441536 0.09442207160618099 0.08651370621966421 0.08919582926962111 0.2867912711117386 1.1840307757003824e-07 6.926637009147602 4.07026835838471 up FAIATK(ub)EGDLPQVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAIATKEGDLPQVER 15 1 J3KNI1;Q9H9E3;A0A6I8PIQ6;A0A0A0MS45;Q9H9E3-3;Q9H9E3-2;J3KRB5 J3KNI1 COG4 Conserved oligomeric Golgi complex subunit 4 1 4360100.0 891500.0 1214100.0 2254500.0 True False 1221111.6418816268 1160457.047508196 1722033.5328849843 1.0 0.9503283792463338 1.410217930795812 20.219763676140847 -6.880153876643655 1.0789104630041477 0.969149331468567 1.442910287151602 0.97381063386605 0.03335122650285883 0.12749525676859638 0.271446577452152 0.02380836447248621 0.05759873952196954 1.3177897443877338e-07 6.880153876643655 0.473760955683035 FAIATK(ub)EGDLPQVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAIATKEGDLPQVER 15 1 J3KNI1;Q9H9E3;A0A6I8PIQ6;A0A0A0MS45;Q9H9E3-3;Q9H9E3-2;J3KRB5 J3KNI1 COG4 Conserved oligomeric Golgi complex subunit 4 1 46010500.0 3214900.0 6447600.0 36348000.0 True False 4161751.4251531875 6088785.3921040865 29733036.961974893 1.0 1.4630343742550573 7.144356768227806 21.988759367072 -6.923076088294139 0.8015888757405251 0.8879934707312082 8.128617707987207 0.9949935106912547 0.1976755383602658 0.09639534751017405 0.09648401772385454 0.17315358650261678 0.5349588731519362 1.1937789363444346e-07 6.923076088294139 7.240624237255998 up FAIGSQVSEHSIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAIGSQVSEHSIIK 14 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 23371300.0 4858100.0 9660000.0 8853200.0 False True 6369016.1459073275 8218765.654385079 7937155.789891029 1.0 1.2904293953888597 1.2462137963006066 22.602639098627435 -10.089355810935132 4.4521777067595565 0.9999765036805471 1.268321595832133 0.9800407050685095 0.01805094279454293 12551774.109573416 0.20973219086510736 3046.480914738547 0.006179317837336558 8.140370824094795e-11 10.089355810935132 0.26834509215158586 FAIGSQVSEHSIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAIGSQVSEHSIIK 14 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 18292700.0 4546400.0 2735300.0 11011000.0 False True 4402077.020573535 3827519.5544010615 8126888.7770806225 1.0 0.8694803694966664 1.8461487018738694 22.069752956767957 -6.873217782795199 1.1170049863883755 0.9245410664289287 1.9069386522873284 0.9677869848878863 0.07770286745445973 0.13380340050452927 0.3100816145604982 0.05387681549889004 0.12831095272589044 1.3390050569887196e-07 6.873217782795199 0.9823975858583996 FAIGSQVSEHSIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAIGSQVSEHSIIK 14 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 31731400.0 3857400.0 24770000.0 3104000.0 False True 5851957.813714237 20349599.97110669 2490493.0394684714 1.0 3.4774003194993646 0.42558287649168064 22.480487938567382 -6.690797124326832 1.863612373943434 2.5520317017708756 0.436052408939891 0.37410990265097244 1.0476008226278777 0.4149799122221974 2.7949495892142915 0.4495988085547745 1.1695989989152686 2.0379938807825202e-07 6.690797124326832 -2.1159792928309846 FAIGSQVSEHSIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAIGSQVSEHSIIK 14 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 24027700.0 4858100.0 5829600.0 13340000.0 False True 6654270.855216077 5572028.996090745 10189366.745924013 1.0 0.8373613153607963 1.5312521788825117 22.665849160150326 -6.844938549683433 1.2592311042756443 0.9134524965072259 1.5564035499165694 0.9326196135156933 0.07691380886505451 0.16311000822762411 0.5002541129864497 0.04785071683089933 0.11043159093927106 1.4290961535701677e-07 6.844938549683433 0.6429510534093434 FAIGSQVSEHSIIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAIGSQVSEHSIIK 14 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 11678500.0 4546400.0 3619500.0 3512600.0 False True 3780533.0396698606 3600001.0350855035 4247068.419572619 1.0 0.952246944362078 1.1234046561707867 21.850158232202233 -6.832256529746109 1.3178856225104874 0.9745217252168742 1.1282234357328074 0.9102976607924059 0.021598431850000196 0.1780427797398329 0.6039827835742911 0.012864963764301282 0.029604161354228765 1.4714430913711043e-07 6.832256529746109 0.15370171051593318 FAIGSQVSEHSIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAIGSQVSEHSIIK 14 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 12118000.0 3857400.0 5590600.0 2670000.0 False True 4993480.340721617 5279478.19546763 2184087.396513502 1.0 1.0572742526717713 0.4373878031925676 22.25161426065983 -6.88429825342741 1.0555045912173955 1.0380003161322746 0.3896630588864689 0.9769916187079478 0.042425827469581935 0.12389218680217479 0.24983914387659092 0.030832554291230132 0.07544784944795394 1.3052741781305072e-07 6.88429825342741 -0.6483372572458057 down FAIGSQVSEHSIIK(ub)DFTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAIGSQVSEHSIIKDFTK 18 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 11015400.0 3339400.0 2615300.0 5060700.0 True False 3233392.5748951472 3659602.9286093274 3735150.8522542785 1.0 1.1318152200334044 1.155180129148222 21.624617248910354 -13.999999998716993 0.24336690152540477 0.11305700617993578 1.165185924099125 0.9995306708425863 0.0014799581043927752 13.744682127762681 0.15612237452440778 5.936236849230314 0.011195455983879306 1.0000000029542339e-14 13.999999998716993 1.052128917919189 FAIGSQVSEHSIIK(ub)DFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAIGSQVSEHSIIKDFTK 18 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 11154300.0 3339400.0 4403600.0 3411300.0 True False 2776859.0605035992 4379876.932753832 4124587.0579308984 1.0 1.5772773616963895 1.4853426004209522 21.40502252434463 -10.684736720148457 6.54907789040236 0.9954221238234402 1.5313099810586033 0.9780375711066471 0.03753220912490065 0.002518305835549134 0.00012122745127746586 0.036479419506855466 0.012113468407259517 2.0666326189685136e-11 10.684736720148457 0.5358878572351631 FAIVMMGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAIVMMGR 8 0 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 0 12955900.0 4235400.0 5010400.0 3710100.0 False True 5552650.415671942 4262867.85038623 3326214.441792201 1.0 0.7677176719705969 0.5990318483591562 22.404745138772206 -7.144095963403731 0.10575977647114837 1.391005581081726 3.871959970920416e-12 0.9999994763321358 0.00011881283276260593 0.08280256395881619 0.0039593448115557645 0.018704579133676923 0.032397352754122415 7.176357021651592e-08 7.144095963403731 -1.3910055810778539 FAIVMMGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAIVMMGR 8 0 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 0 11469800.0 5365900.0 1872700.0 4231200.0 False True 5195562.4416451575 2620478.8760014875 3122921.786720874 1.0 0.5043686618020361 0.601074825256457 22.30884850475784 -9.923065750874608 5.66007704086968 1.000000358960754 0.5527217435286241 0.966127409489731 0.03948012590996743 1.788696089463893e-07 3.4015694082357794e-08 0.03822649829639004 0.012742155845943137 1.193807351949693e-10 9.923065750874608 -0.4472786154321299 FAIVMMGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAIVMMGR 8 0 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 0 31505700.0 8156700.0 10496000.0 12853000.0 False True 12374310.234645842 8622906.794377698 10312598.916329969 1.0 0.6968393899027285 0.833387778452212 23.56084477333993 -10.036211944922897 4.602157672189609 1.0000083351210474 0.7651135841844782 0.7977882970409181 0.0557456462319753 17615318.276393574 19207410.641010366 1241.2313768920656 0.01908321792082232 9.20000482421692e-11 10.036211944922897 -0.2348947509365692 FAIVMMGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAIVMMGR 8 0 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 0 18341800.0 4235400.0 6820300.0 7286100.0 False True 5801341.837381308 6518956.594283958 5565273.241939793 1.0 1.123698064519945 0.9593079321889995 22.467955200295098 -6.705427639537653 1.8120341340579582 1.0764014567374054 0.9597523673706928 0.443163062912848 0.05216463308426408 0.3843195428888442 2.457008999465716 0.02293717473173532 0.05858499350676381 1.9704814938519008e-07 6.705427639537653 -0.11664908936671259 FAIVMMGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAIVMMGR 8 0 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 0 12711800.0 5365900.0 4750500.0 2595400.0 False True 4461983.599675462 4724908.1135995835 3138086.1402262636 1.0 1.0589254774363683 0.7032939655929057 22.089253780192116 -6.864347538848741 1.163674476752336 1.0324169011709854 0.6845947580914222 0.9587035257355541 0.03162598081189292 0.1423843952903068 0.3639513536129186 0.021157785482518197 0.04965274512871113 1.3666347551439142e-07 6.864347538848741 -0.34782214307956316 FAIVMMGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAIVMMGR 8 0 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 0 35728700.0 8156700.0 14772000.0 12800000.0 False True 10559008.94259449 13949925.214368371 10470531.339090962 1.0 1.321139634430567 0.9916206526593028 23.33197109543238 -6.652028190398619 2.000939990828693 1.2080502402214932 0.9929966227842886 0.2024194003408919 0.13699737249043273 0.5036078963660272 3.867012003310685 0.055477876517403886 0.1517927290715283 2.2282905044752323e-07 6.652028190398619 -0.21505361743720464 FAK(ub)AGPEGIEPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAKAGPEGIEPR 12 1 Q14146 Q14146 URB2 Unhealthy ribosome biogenesis protein 2 homolog 1 35304100.0 5669700.0 6447800.0 23186600.0 True False 8601349.410591489 5297139.713108663 18603758.346952192 1.0 0.6158498463724653 2.1628883398277003 23.036131582075065 -6.840979598736644 1.2777905382348642 0.7956533657568002 2.214779301115722 0.9261262553313808 0.17876300496818665 0.16766384739172818 0.5313364052249567 0.10967932940800976 0.25275675316550195 1.442183097414691e-07 6.840979598736644 1.419125935358922 up FAK(ub)AGPEGIEPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAKAGPEGIEPR 12 1 Q14146 Q14146 URB2 Unhealthy ribosome biogenesis protein 2 homolog 1 7665400.0 1351200.0 1240800.0 5073400.0 True False 1850775.1548070125 1185977.3532231036 3875167.409952834 1.0 0.6408003425714724 2.0938077755625115 20.819698206429873 -6.841294546539515 1.2763804246588537 0.8089377617412749 2.1428331216466865 0.9266573212856715 0.16735013725420916 0.16729056349279467 0.5288546506919262 0.10278764314950466 0.23688977549650247 1.4411376138533876e-07 6.841294546539515 1.3338953599054117 up FAK(ub)AGPEGIEPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAKAGPEGIEPR 12 1 Q14146 Q14146 URB2 Unhealthy ribosome biogenesis protein 2 homolog 1 40538500.0 5669700.0 5242400.0 29626400.0 True False 7339538.4164954005 4950655.831560039 24234699.1925347 1.0 0.6745186891363063 3.3019377810010386 22.807257904167514 -6.875870744980916 1.102512166241332 0.8074260543623792 3.4740443111681274 0.9702019415512068 0.20186906285993889 0.131353441007 0.29489180858758546 0.1415249200633377 0.33894424283915187 1.3308504476572496e-07 6.875870744980916 2.666618256805748 up FAK(ub)AIADDQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAKAIADDQR 10 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 9959700.0 1007400.0 2346000.0 6606300.0 True False 1528299.4508051309 1927337.9706183365 5300561.9093558425 1.0 1.2610996945677015 3.468274431796352 20.543495818106706 -6.9290847794151995 0.7542666166485273 0.9652713468526649 3.9110133841669046 0.9963553127124997 0.06684045423032339 0.09311577008558385 0.08002865866733819 0.06056669692297411 0.2007256084927979 1.1773761133547035e-07 6.9290847794151995 2.94574203731424 up FAK(ub)AIADDQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAKAIADDQR 10 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 7613300.0 1007400.0 2266400.0 4339500.0 True False 1304099.158822769 2140272.8476742837 3549755.5270300917 1.0 1.6411887341498954 2.721998172466051 20.314622140199155 -6.963246290691869 0.38697760818021654 0.9313439506301174 3.4704898331302703 0.9998722971445129 0.008030163128501437 0.07856128559221426 0.016990738635221686 0.013981129663793659 0.09103468462186787 1.0883127304041339e-07 6.963246290691869 2.539145882500153 FAK(ub)EFMDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAKEFMDR 8 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 2976120.0 993890.0 1129100.0 853130.0 True False 1302999.4148444517 960642.6811973286 764856.2914008197 1.0 0.7372548830438327 0.5869966499502427 20.313405005339817 -13.37130154120586 0.0677674143322761 2.44742524416585 9.823047208310062e-08 0.9999419497138803 0.0013004090665366876 9.965885023305738 0.06368047298562922 2.4826461136979456 0.5084745826466586 4.253030123834437e-14 13.37130154120586 -2.447425145935378 FAK(ub)EFMDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAKEFMDR 8 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 11329500.0 1643800.0 1853700.0 7832000.0 True False 2493764.7778771883 1522892.7519757957 6284001.7671124535 1.0 0.6106801914461856 2.5198855252345393 21.249893959995283 -6.8535898561770425 1.217601161897831 0.7914144727434589 2.6016770918800485 0.9453701703008357 0.19252915124522857 0.1535553884750878 0.43627538063776833 0.12360374037257459 0.2867690592193203 1.400909704642178e-07 6.8535898561770425 1.8102626191365896 up FAK(ub)EFMDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAKEFMDR 8 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 3166560.0 993890.0 747370.0 1425300.0 True False 1361357.9918673357 714348.7221779086 1088673.4949749247 1.0 0.5247324557136195 0.7996967009989947 20.37661506686271 -10.22018322387274 5.626602492392304 1.000013833175471 0.6622145783562954 0.668015172496355 0.11225368307648516 1.947988278935717e-05 2.6999281492831963e-06 0.10869360849528877 0.03622972042546624 6.023054266966858e-11 10.22018322387274 -0.3377992548191757 FAK(ub)EFMDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAKEFMDR 8 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 10170300.0 1643800.0 2350200.0 6176300.0 True False 2127931.5041422197 2219409.3040081644 5052276.774189653 1.0 1.0429890716350008 2.374266636099385 21.021020282087733 -6.913773890840832 0.8696353595552356 0.963536078267345 2.5609611691147096 0.9922696032567466 0.05608977223886538 0.10197518634091493 0.12562009289315662 0.04679611897747506 0.13282041055672006 1.2196244135200432e-07 6.913773890840832 1.5974250908473646 up FALGLSGGSLVSMLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FALGLSGGSLVSMLAR 16 0 O95336;M0R261;M0R0U3 O95336 PGLS 6-phosphogluconolactonase 0 106191000.0 31957000.0 33444000.0 40790000.0 False True 48481105.3696443 27475656.900835305 32727838.621107887 1.0 0.5667291760645121 0.675063787666853 25.530919256857473 -9.986287198605178 6.999885032358678 1.0000000304007823 0.6208964818656898 0.942288295760577 0.04422741998472421 2.1022738029018632e-08 3.0082953180387724e-09 0.042823019090304254 0.01427433842054621 1.032078667214199e-10 9.986287198605178 -0.37910354853509254 FALGLSGGSLVSMLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FALGLSGGSLVSMLAR 16 0 O95336;M0R261;M0R0U3 O95336 PGLS 6-phosphogluconolactonase 0 71853000.0 31957000.0 20597000.0 19299000.0 False True 41368966.466646135 19450758.84378186 15786780.024462221 1.0 0.4701775389884129 0.38160924414658426 25.302045578949922 -13.999999999999998 0.2516907056815265 4.7162947943604205 0.34656570108010737 0.9995458919160859 0.005818453051405604 14.065616734919173 0.15874891829514157 26.454406915704638 0.04049306832141861 1.0000000000000041e-14 13.999999999999998 -4.369729093280313 FALGSVVAVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FALGSVVAVTK 11 0 Q01780;Q01780-2;K7EJ37 Q01780 EXOSC10 Exosome component 10 0 6523400.0 1967000.0 1448400.0 3108000.0 False True 2578756.048455093 1232304.3658189797 2786413.9740411756 1.0 0.47786775587292984 1.0805263939993426 21.298243869271488 -6.677566947877399 1.9103550446470206 0.6689255260961512 1.0782007010944477 0.31309453481984895 0.22141016182623535 0.4439553345836221 3.1302890338457914 0.09306804557675846 0.24624443921838113 2.101033863021074e-07 6.677566947877399 0.40927517499829646 FALGSVVAVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FALGSVVAVTK 11 0 Q01780;Q01780-2;K7EJ37 Q01780 EXOSC10 Exosome component 10 0 4696000.0 1967000.0 1031200.0 1697800.0 False True 2694253.056176282 985638.1742776146 1296814.607288589 1.0 0.36582984364373133 0.4813262081361595 21.36145393079438 -10.222647573199774 5.9606547075822975 1.0000134032674957 0.42357802589153165 0.9707697143123516 0.04715119335883829 8.398682327399758e-06 1.0952541352849932e-06 0.045655007042026276 0.015217982219380264 5.988973987856831e-11 10.222647573199774 -0.5764353773759641 FALPYIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FALPYIR 7 0 P06132;Q5T446;A0A1B0GVN9;A0A494C0Q8;A0A494C085;A0A494C0S8;H0Y5R6 P06132 UROD Uroporphyrinogen decarboxylase 0 3649240.0 1104900.0 932940.0 1611400.0 False True 1448534.5998668193 793748.9885716375 1444667.7856402681 1.0 0.5479668822854602 0.9973305337498277 20.46616271472649 -10.942205037618535 10.09766587857262 1.0593066245739577 0.7726487080176441 0.2544552543626243 0.1834519425069272 0.10668993301943624 0.0006106493826005962 0.07737186571468548 0.059208859846560796 1.1423388903476945e-11 10.942205037618535 -0.2866579165563137 FALPYIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FALPYIR 7 0 P06132;Q5T446;A0A1B0GVN9;A0A494C0Q8;A0A494C085;A0A494C0S8;H0Y5R6 P06132 UROD Uroporphyrinogen decarboxylase 0 4008600.0 1104900.0 1111400.0 1792300.0 False True 1513411.3887997842 1062294.6730916807 1368995.6535771799 1.0 0.7019206284248574 0.90457602189902 20.52937277624938 -10.08358375150971 4.999783323435395 1.0000051527107148 0.8032483259989206 0.5568908006111644 0.08273371794218014 4.752027021466426e-06 8.709930238482691e-07 0.08010867499201636 0.026702192646217645 8.249283868421876e-11 10.08358375150971 -0.19675682671179417 FALQLGDPSTGLLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FALQLGDPSTGLLIR 15 0 Q86TN4-2;Q86TN4;Q86TN4-4;F5H6B6;F5H8A0;Q86TN4-3 Q86TN4-2 TRPT1 tRNA 2-phosphotransferase 1 0 7395600.0 3512100.0 2132700.0 1750800.0 False True 2920466.762410816 2121210.721792193 2116884.1852154345 1.0 0.7263259247097732 0.7248444709118922 21.47776753500477 FALTFGLDQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FALTFGLDQLK 11 0 Q8N3U4-2;Q8N3U4 Q8N3U4-2 STAG2 Cohesin subunit SA-2 0 4638250.0 896850.0 1979100.0 1762300.0 False True 1175779.0351077542 1683825.9944713772 1579954.1011752756 1.0 1.4320939089690974 1.3437508698481606 20.165185528386967 -10.021441381452435 4.661630626282694 0.9999912346992845 1.3879223894223915 0.9625593174498663 0.036065894771565306 24909710.844961006 1.1095008217742486 2845.6691346234015 0.012346315065305806 9.518283117021177e-11 10.021441381452435 0.387931154723107 FALTFGLDQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FALTFGLDQLK 11 0 Q8N3U4-2;Q8N3U4 Q8N3U4-2 STAG2 Cohesin subunit SA-2 0 7413500.0 2986100.0 2336800.0 2090600.0 False True 2891307.8900085012 3269896.4262510133 1543009.1433443592 1.0 1.1309402355767095 0.5336716814824666 21.463290816235645 -6.849245600505369 1.238668537927905 1.0698345095393815 0.5101333039969659 0.9392057084630206 0.06320155072678252 0.15829138077524166 0.46772796249304416 0.03993285242796314 0.09236679092247499 1.4149933521820504e-07 6.849245600505369 -0.5597012055424156 FALTFGLDQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FALTFGLDQLK 11 0 Q8N3U4-2;Q8N3U4 Q8N3U4-2 STAG2 Cohesin subunit SA-2 0 5700950.0 896850.0 1715300.0 3088800.0 False True 1228439.6814599396 1639512.374261435 2359289.0558328414 1.0 1.3346299366631953 1.9205575100186796 20.22839558990986 -6.962559556565631 0.39771964240249663 0.966969435232352 2.309533860810174 0.9998536673152999 0.0046022868974220366 0.0787991578205473 0.017843524822692736 0.0075421483505537755 0.04913353950271905 1.090035001209708e-07 6.962559556565631 1.3425644255778217 FALTFGLDQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FALTFGLDQLK 11 0 Q8N3U4-2;Q8N3U4 Q8N3U4-2 STAG2 Cohesin subunit SA-2 0 7773300.0 2986100.0 1898900.0 2888300.0 False True 2483074.4566598157 1888670.248797861 3492230.1760096774 1.0 0.760617646294209 1.4064137974772446 21.24369609166992 -6.806331898794745 1.429778144717486 0.8689603268142614 1.416800251463568 0.850057585983605 0.10322170588476569 0.21184909677162528 0.8541931945214832 0.056776359773508166 0.13157419284156116 1.5619535021485555e-07 6.806331898794745 0.5478399246493066 FAMEPEEFDSDTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAMEPEEFDSDTLR 14 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 10850300.0 3073200.0 1513400.0 6263700.0 False True 2975642.948184631 2117708.512276742 4623049.063027873 1.0 0.7116809876563671 1.5536303056279939 21.504769995035254 -6.81426012997792 1.39639300515385 0.8436360731693829 1.5698626191039928 0.8706923524713205 0.12563002755970357 0.20105017063351743 0.7717819162410154 0.07072280742840971 0.16331613847690143 1.5336980663320376e-07 6.81426012997792 0.7262265459346099 FAMK(ub)EMGTPDVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAMKEMGTPDVR 12 1 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2;B8ZZK4 H7C2W9 RPL31 60S ribosomal protein L31 1 8989100.0 2159100.0 4078900.0 2751100.0 True False 2830601.0087541398 3470344.019427668 2466442.562414629 1.0 1.2260096031531849 0.8713494253646891 21.432676975841343 -6.734563963954817 1.706774711680334 1.135315988494712 0.8713853066293491 0.5802288475167388 0.09497958927889932 0.3277382864423912 1.8724025930254096 0.04406499862705507 0.10877613935151316 1.8426210832389516e-07 6.734563963954817 -0.26393068186536284 FAMK(ub)EMGTPDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAMKEMGTPDVR 12 1 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2;B8ZZK4 H7C2W9 RPL31 60S ribosomal protein L31 1 6441500.0 2159100.0 1488500.0 2793900.0 True False 2957377.617483585 1422733.1481887377 2134038.3621766916 1.0 0.48107929801650856 0.7215981988774677 21.495887037364234 -10.380499342019348 5.963129889737916 1.0000806196921648 0.6013387484469893 0.785550226295473 0.09819143010073496 0.00010526358714501846 1.0935580203238321e-05 0.09509255141955694 0.031691147793369505 4.1639035187957016e-11 10.380499342019348 -0.39874187124517546 FAMK(ub)EMGTPDVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAMKEMGTPDVR 12 1 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2;B8ZZK4 H7C2W9 RPL31 60S ribosomal protein L31 1 9860400.0 2615500.0 4741400.0 2503500.0 True False 2174904.136296087 4715857.137105791 3026970.275123854 1.0 2.168305746632588 1.3917718140344595 21.052520381716263 -10.106069031494926 4.809947346542111 0.9999608851453691 1.7800387803403763 0.5736328342077521 0.31701865049397027 0.0001329852810080288 2.471533949018395e-05 0.30696732553852846 0.10231732948000243 7.833051258226326e-11 10.106069031494926 0.7800778951950073 FANFSGGK(ub)ITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FANFSGGKITK 11 1 K7EMM6;E9PEW0;A0A075B784;Q9P275 K7EMM6 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 47746700.0 15964000.0 13851000.0 17931700.0 True False 20928958.595595904 11784484.790775135 16076299.697012257 1.0 0.5630707680436118 0.7681366286612658 24.31899719050423 -10.081738410129896 4.91871328207494 1.000009156781785 0.6656036983524432 0.7800011907869338 0.08371778703959325 116338897.64357193 9.186265208829695 13408.697525535117 0.028658825264727482 8.284410107670512e-11 10.081738410129896 -0.3344054584293419 FANFSGGK(ub)ITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FANFSGGKITK 11 1 K7EMM6;E9PEW0;A0A075B784;Q9P275 K7EMM6 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 53760600.0 16120600.0 16250900.0 21389100.0 True False 15608860.376970323 22739969.117323972 15786653.050754242 1.0 1.4568628694299204 1.0113904967749112 23.895861872346583 -10.53507909137619 3.212456653793953 0.9924872304728365 1.2341266833078268 0.26916488625595913 0.18186333529692258 56465178.261674486 72823552.45466934 3707383.467531003 0.06655517064922531 2.9168957562544215e-11 10.53507909137619 0.24163945283499033 FANFSGGK(ub)ITK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FANFSGGKITK 11 1 K7EMM6;E9PEW0;A0A075B784;Q9P275 K7EMM6 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 103234200.0 38135500.0 26400900.0 38697800.0 True False 57854341.57849825 21689453.123826787 31049162.868151724 1.0 0.3748975881852874 0.5366781821554987 25.78592189214834 -10.51333672227154 9.489930791565335 1.0000131028986294 0.45578788517101054 0.9378406103373877 0.0660466509185671 1.8310221006784267e-05 9.390147890907107e-07 0.06395092849891144 0.02131646492336544 3.066643400624346e-11 10.51333672227154 -0.5442252177276189 FANFSGGK(ub)ITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FANFSGGKITK 11 1 K7EMM6;E9PEW0;A0A075B784;Q9P275 K7EMM6 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 39741100.0 15964000.0 9494800.0 14282300.0 True False 21866322.2108786 9075288.340895154 10909114.89320167 1.0 0.41503496808348295 0.4989003083369152 24.382207252027122 -10.710570323116709 6.846140593821422 1.0056669507749867 0.45696763821055625 0.9824258368479346 0.03423788178763391 0.002968636842264893 0.0001255029004671389 0.03323116627075973 0.011050228831077024 1.9472857102512425e-11 10.710570323116709 -0.5486993125644304 FANFSGGK(ub)ITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FANFSGGKITK 11 1 K7EMM6;E9PEW0;A0A075B784;Q9P275 K7EMM6 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 33222300.0 16120600.0 5256700.0 11845000.0 True False 13404993.163668416 5228381.113726741 14321734.734907921 1.0 0.3900323595760745 1.0683880670468489 23.67626714778086 -6.669788569291769 1.938366623528104 0.6105786962599825 1.0656270228711795 0.2779718367261582 0.2591156320978513 0.4616242595288019 3.343720893195784 0.10763148087199076 0.28761803667466 2.1390031823739275e-07 6.669788569291769 0.455048326611197 FANFSGGK(ub)ITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FANFSGGKITK 11 1 K7EMM6;E9PEW0;A0A075B784;Q9P275 K7EMM6 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 1 91333700.0 38135500.0 19566500.0 33631700.0 True False 49367156.51308891 18477607.074664176 27511075.690383244 1.0 0.37428947461790985 0.5572748692359691 25.55704821424079 -10.365655129530834 5.035619332243164 1.000341506586598 0.46578217192687754 0.9191219788693565 0.07470347453294497 0.00028659275367086883 3.6102397685301324e-05 0.0723764152470078 0.024110442730788915 4.30868624695971e-11 10.365655129530834 -0.5345593346597204 FANFTGGK(ub)IAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FANFTGGKIAK 11 1 E7EWZ4;C9JPC9;Q9H9J4-2;Q9H9J4 E7EWZ4 USP42 Ubiquitin carboxyl-terminal hydrolase 42 1 6574400.0 1187300.0 2291500.0 3095600.0 True False 1556561.7978295558 1949617.1321970397 2775297.0070919762 1.0 1.2525150847949331 1.782966157181684 20.56993142441743 -6.9590734366199785 0.4483072202271355 0.9825949780955201 2.0738554424130697 0.9997342580823786 0.005319020538874158 0.08003387380413256 0.022367491289018476 0.007072408048748593 0.043888297961610846 1.0988200197770309e-07 6.9590734366199785 1.0912604643175496 FANFTGGK(ub)IAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FANFTGGKIAK 11 1 E7EWZ4;C9JPC9;Q9H9J4-2;Q9H9J4 E7EWZ4 USP42 Ubiquitin carboxyl-terminal hydrolase 42 1 10914600.0 2279000.0 3145800.0 5489800.0 True False 2206654.3924615313 4401934.34513028 4051856.689530219 1.0 1.994845391361855 1.8361990456558797 21.07342926086929 -10.18387254649739 4.919752230251138 0.999911587287074 1.9155222184422411 0.9779752245907357 0.06476709942954129 6.281511526004192e-05 1.0420223606751928e-05 0.0627164665655577 0.020903491455102913 6.548283199982827e-11 10.18387254649739 0.9156106311551672 FANFTGGK(ub)IAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FANFTGGKIAK 11 1 E7EWZ4;C9JPC9;Q9H9J4-2;Q9H9J4 E7EWZ4 USP42 Ubiquitin carboxyl-terminal hydrolase 42 1 9688200.0 1187300.0 2811300.0 5689600.0 True False 1626276.895576057 2687087.4702741043 4345833.660990202 1.0 1.6522939467342606 2.672259362973258 20.63314148594032 -6.964557542406099 0.3655712065550205 0.9175180433743606 3.442292855567607 0.9999037260335041 0.006752326083724408 0.07811147975781353 0.01539164266392076 0.013541389933512126 0.08683636170349898 1.0850317774271076e-07 6.964557542406099 2.5247748121932467 FANSLVGVQQQLQAFNTYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FANSLVGVQQQLQAFNTYR 19 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 6236700.0 2828100.0 0.0 3408600.0 False True 2738323.5135236764 0.0 2515785.404191903 1.0 0.0 0.9187319875709604 21.384861470187584 -9.402049674541765 17.21768478650618 1.0000000027662077 0.45936600983728687 0.31586902252536475 0.37507076332031186 0.0 0.0 0.36316070499721825 0.12105356833240605 3.9623271062171537e-10 9.402049674541765 -0.5406339929289208 FANSLVGVQQQLQAFNTYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FANSLVGVQQQLQAFNTYR 19 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 2828100.0 2828100.0 0.0 0.0 False True 2351690.4560730155 0.0 0.0 1.0 0.0 0.0 21.16526674562186 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 FAPSPTGFLHLGGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAPSPTGFLHLGGLR 15 0 H3BTB7;Q5JPH6;Q5JPH6-2 H3BTB7 EARS2 Probable glutamate--tRNA ligase, mitochondrial 0 7487700.0 2186400.0 1694800.0 3606500.0 False True 2866391.5731277205 1441942.446278658 3233333.9759908277 1.0 0.50305145319181 1.1280154485183302 21.450804276628805 -6.694863026724784 1.8492298322788874 0.6898718113831247 1.1259846429636449 0.39321176877929387 0.20997208404022735 0.40631168028361003 2.6975265379096993 0.09071181499122713 0.23477400980203533 2.0190030419369893e-07 6.694863026724784 0.43611283158052017 FAPSPTGFLHLGGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAPSPTGFLHLGGLR 15 0 H3BTB7;Q5JPH6;Q5JPH6-2 H3BTB7 EARS2 Probable glutamate--tRNA ligase, mitochondrial 0 7478800.0 2186400.0 2790300.0 2502100.0 False True 2994771.1652383497 2667015.319711816 1911155.51236705 1.0 0.8905572988911665 0.6381641223712476 21.514014338151696 -6.95716718185065 0.47367566459061267 1.0064337590257835 0.5118765457731473 0.9996502645244477 0.0028334681521688778 0.08072907288825812 0.024991680946111438 0.0035143060276466758 0.020826425488407206 1.1036536861491845e-07 6.95716718185065 -0.49455721325263613 FAPSPTGFLHLGGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAPSPTGFLHLGGLR 15 0 H3BTB7;Q5JPH6;Q5JPH6-2 H3BTB7 EARS2 Probable glutamate--tRNA ligase, mitochondrial 0 6124800.0 2920900.0 1870300.0 1333600.0 False True 2428857.767810073 1860224.322674517 1612449.5941302842 1.0 0.7658844199641002 0.6638715595043321 21.211846578572114 -13.999999999517879 0.11301501819411275 2.1242444898891306 0.4846011128537559 0.9997277836893239 0.0023215988253049978 11.995772472782038 0.10249325603911527 3.0608745581261694 0.15913212296540222 1.0000000011101247e-14 13.999999999517879 -1.6396433770353747 FAQFFLCPLFDESCKDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAQFFLCPLFDESCKDR 17 1 A0A3B3ISG5;P14735;Q5T5N3 A0A3B3ISG5 IDE Insulin-degrading enzyme 0 4706410.0 803610.0 2501200.0 1401600.0 False True 1053540.4921703096 2128030.709601237 1256575.8770965596 1.0 2.01988506888564 1.1927172106199677 20.006814333627148 -10.278051489754922 4.837521988740404 0.9998049047967782 1.6063011397534894 0.4173698983661682 0.33768986406597945 0.0007107662496427139 0.00010607440318546218 0.32707043752028664 0.1089889349755457 5.271673569971784e-11 10.278051489754922 0.6064962349567112 FAQFFLCPLFDESCKDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAQFFLCPLFDESCKDR 17 1 A0A3B3ISG5;P14735;Q5T5N3 A0A3B3ISG5 IDE Insulin-degrading enzyme 0 6214410.0 803610.0 2880400.0 2530400.0 False True 1100726.3337436826 2753134.403790959 1932771.635223845 1.0 2.5011979085003517 1.7559056924261014 20.07002439515004 -10.257200259457548 8.871904235764807 0.9999997099525857 2.1285518004632267 0.7535266127237318 0.3042642731083367 1.745749002681961e-06 1.4646430525905823e-07 0.29460269026688374 0.09820087188287442 5.530950103084867e-11 10.257200259457548 1.128552090510641 FAQHGTFEYEYSQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAQHGTFEYEYSQR 14 0 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 83410000.0 34407000.0 34133000.0 14870000.0 False True 45107910.19786198 29040489.44939194 13331395.043112053 1.0 0.6438003738592261 0.29554450615501876 25.42687711326992 -7.440254055179529 0.2900500059254947 1.0921405608812735 5.322236434261148e-11 0.9997914644551381 0.004153141853865127 0.12021875783048969 0.026802700756858953 0.020269353325491613 0.06040085959846906 3.6286572214903576e-08 7.440254055179529 -1.0921405608280512 down FAQHGTFEYEYSQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAQHGTFEYEYSQR 14 0 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 51460900.0 15534000.0 7348900.0 28578000.0 False True 15040881.672881704 10283354.094007218 21092564.478377085 1.0 0.6836935704738522 1.4023489405149965 23.84238580222526 -6.78709691145675 1.5082158148445757 0.8225454721766784 1.4093605959461466 0.7916816173887663 0.13422825590878362 0.23971045173951802 1.0772848294946382 0.07006850009399015 0.16437984807710004 1.632687578109884e-07 6.78709691145675 0.5868151237694682 FAQHGTFEYEYSQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAQHGTFEYEYSQR 14 0 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 98751000.0 34407000.0 32028000.0 32316000.0 False True 47128197.71421325 30612897.05756732 24683626.368911568 1.0 0.6495664706553136 0.5237549400593206 25.490087174792812 -13.999999999999998 0.14260581857940424 2.678214787153776 0.37283837068002496 0.9995927519233202 0.0040664627173343975 11.937564141963174 0.11849908744240714 5.567238555317434 0.13516761886253775 1.0000000000000041e-14 13.999999999999998 -2.305376416473751 FAQHGTFEYEYSQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAQHGTFEYEYSQR 14 0 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 38479000.0 15534000.0 13601000.0 9344000.0 False True 12917209.272882214 13527728.71341289 11297787.198225392 1.0 1.0472640357242158 0.8746306543119526 23.622791077659535 -6.833741753780295 1.3111805849575435 1.025196372571823 0.869622362126917 0.9131399660527162 0.021468020308845318 0.17623905573013596 0.5912425987646821 0.012850430300066952 0.02957277166846443 1.4664195645305891e-07 6.833741753780295 -0.15557401044490593 FAQHGTFEYEYSQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAQHGTFEYEYSQR 14 0 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 60890000.0 12356000.0 32455000.0 16079000.0 False True 15995085.573172666 30648850.719762105 13152786.984472139 1.0 1.9161417161260506 0.8223017578932058 23.93112537505597 -6.684543038752194 1.8860045246019759 1.5772763138696648 0.8263297942858324 0.3449581560370356 0.38790308129236706 0.4284866298811365 2.950594436903338 0.1648123160825354 0.4321268509210499 2.067554476313152e-07 6.684543038752194 -0.7509465195838324 FAQIVQK(ub)GGQ ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAQIVQKGGQ 10 1 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 1 123035000.0 0.0 83416000.0 39619000.0 True False 0.0 70970657.95302136 35519605.93228353 0.0 FAQIVQK(ub)GGQ ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAQIVQKGGQ 10 1 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 1 249300000.0 122870000.0 0.0 126430000.0 True False 118969559.10563776 0.0 93314190.18130071 1.0 0.0 0.7843535008685992 26.826017235611967 -10.823497081216482 9.361107906452721 1.0135367481478714 0.3921767504347402 0.4446603219669448 0.32021097584895175 0.08522379490034752 0.001606884837196687 0.29208063856591565 0.10334764806131799 1.5014224964015958e-11 10.823497081216482 -0.6213599977131312 FAQIVQK(ub)GGQ ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAQIVQKGGQ 10 1 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 1 598430000.0 223140000.0 120020000.0 255270000.0 True False 338519693.71913606 98601493.27945998 204815772.61118418 1.0 0.29127254664618696 0.605033551699702 28.33466452555639 -10.515841971829456 6.301922280361562 1.0004905602813925 0.4481530491738007 0.8048614652323167 0.128092393927321 0.0008835972007612748 6.788424941786508e-05 0.12412885726973134 0.04134164237136286 3.0490042390665766e-11 10.515841971829456 -0.5523375111075918 FAQIVQK(ub)GGQ ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAQIVQKGGQ 10 1 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 1 94884000.0 0.0 66153000.0 28731000.0 True False 0.0 63230141.72128289 21945329.53351893 0.0 FAQIVQK(ub)GGQ ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAQIVQKGGQ 10 1 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 1 405851000.0 122870000.0 239150000.0 43831000.0 True False 102171849.06392683 237861651.48244157 52995859.44835372 1.0 2.32805468102683 0.5186933576507488 26.606422511046244 -6.710012168015886 1.795283704865991 1.8164694098024239 0.5229747356419207 0.4650510852395341 0.5596366640903239 0.375080064597399 2.3565793081723516 0.24807421358323373 0.6301869486684736 1.9497899699879584e-07 6.710012168015886 -1.2934946741605033 FAQIVQK(ub)GGQ ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAQIVQKGGQ 10 1 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 1 489071000.0 223140000.0 169330000.0 96601000.0 True False 288859128.7469856 159906636.64696702 79020609.209963 1.0 0.5535800005373233 0.2735610591665873 28.10579084764884 -8.492429609994371 0.22037300565879206 1.2794583067317724 4.244629376013588e-22 0.9995888623638376 0.006065715146716318 0.15643447388821377 0.056449038942849236 0.14239708836947274 0.11898206561691504 3.2178840417873386e-09 8.492429609994371 -1.2794583067317724 down FAQK(ub)MLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAQKMLR 7 1 P18124 P18124 RPL7 60S ribosomal protein L7 1 3290370.0 884170.0 1279700.0 1126500.0 True False 1159155.4323144595 1088773.7482315314 1009940.5861510242 1.0 0.9392819270644329 0.871272788787694 20.144642601064774 -6.969660117668121 0.2662561878471054 1.0176926146529675 0.7908279278579672 0.9999795686846101 0.0002376002028495196 0.07641380474431911 0.009427895321747594 0.0013643669494343654 0.006358396620196913 1.0723582130332906e-07 6.969660117668121 -0.22686468679500027 FAQK(ub)MLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAQKMLR 7 1 P18124 P18124 RPL7 60S ribosomal protein L7 1 2689730.0 884170.0 869880.0 935680.0 True False 1211071.542795824 831445.8252915152 714691.6549344962 1.0 0.68653733153706 0.5901316558760781 20.207852662587666 -13.999999999427613 0.16514234629886904 2.561714973917195 0.5005389317357787 0.9995237957009113 0.003818309601176558 12.047928407284505 0.12857615831405125 6.025814835987496 0.0822154722432985 1.0000000013179688e-14 13.999999999427613 -2.0611760421814163 FAQK(ub)MLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAQKMLR 7 1 P18124 P18124 RPL7 60S ribosomal protein L7 1 4734270.0 1244000.0 2525900.0 964370.0 True False 1034441.118544192 2512292.4753481047 1166015.3082569153 1.0 2.428647150921213 1.1271935031912619 19.98042009716887 -6.623866782256386 2.101960667559686 1.9453200682385878 1.1321990721310806 0.09617649309206378 0.6137530416515394 0.5750870425612917 4.8332315888498565 0.23944454713796184 0.68053350365643 2.3775694827845345e-07 6.623866782256386 -0.8131209961075072 FAQK(ub)MLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAQKMLR 7 1 P18124 P18124 RPL7 60S ribosomal protein L7 1 5994100.0 1863800.0 2510800.0 1619500.0 True False 2412725.8409905485 2371071.7728294153 1324767.6174732673 1.0 0.9827356811729459 0.5490750730838866 21.202232560172288 -6.915289265111327 0.8589277547337452 1.0112869460356613 0.48619470043236 0.9927693676437543 0.017739431400004006 0.10102363298480341 0.120560254684569 0.014914584712248604 0.04284890007973251 1.2153762205088033e-07 6.915289265111327 -0.5250922456033013 FAQPGSFEYEYAMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAQPGSFEYEYAMR 14 0 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 58548000.0 15356000.0 21509000.0 21683000.0 False True 20131864.707715556 18299941.041425347 19439451.158022754 1.0 0.9090037762081661 0.9656060896620553 24.26297747183991 -10.573545872919166 6.05389643530715 1.0001642571380267 0.9373049329351106 0.6206122761003591 0.023107797703849988 5.136341241404848e-05 3.618195154918267e-06 0.022432537998216973 0.007458009639545081 2.669648767115392e-11 10.573545872919166 -0.06285932420291607 FAQPGSFEYEYAMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 FAQPGSFEYEYAMR 14 0 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 66025800.0 20422900.0 7068700.0 38534200.0 False True 19774586.218430277 9891268.772783516 28440937.018779423 1.0 0.500201049140774 1.4382569983826994 24.237144170951865 -6.761983417941272 1.6052305246886942 0.7104035635460116 1.4419973768083651 0.6989336030425868 0.21027884321251647 0.2795942634007131 1.4204019050630607 0.10334016003961115 0.24783629527761517 1.729882407634455e-07 6.761983417941272 0.7315938132623535 FAQPGSFEYEYAMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAQPGSFEYEYAMR 14 0 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 92683400.0 6925500.0 77323000.0 8434900.0 False True 10506489.82186912 63524106.52264359 6767738.317852001 1.0 6.046177895724888 0.6441483723483977 23.324777415106407 -6.661497433116951 1.9674081308743132 4.244159586027875 0.6665441928557484 0.24201348330126027 2.147784122575147 0.48093433280343023 3.5800653144176544 0.8814714661102545 2.381585738651129 2.1802312833321406e-07 6.661497433116951 -3.5776153931721266 FAQPGSFEYEYAMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FAQPGSFEYEYAMR 14 0 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 60832600.0 17773200.0 20050200.0 23009200.0 False True 24344432.34267021 19164315.866855126 17574900.849348906 1.0 0.7872155570152471 0.7219269113350462 24.537088524811896 -13.999999999884738 0.16547986699060813 2.0609772503281287 0.66147334332084 0.9995230362940731 0.0025929272917244333 12.050767880682468 0.1287167192543084 4.103097188333072 0.05550223202550657 1.0000000002654017e-14 13.999999999884738 -1.3995039070072888 FAQPGSFEYEYAMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FAQPGSFEYEYAMR 14 0 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 41177400.0 20422900.0 10620500.0 10134000.0 False True 16982546.237874746 10563285.258495815 12252972.54567809 1.0 0.62200833199779 0.7215038530765967 24.01754944638614 -10.034096728399204 7.076085356756721 1.0000000480156352 0.671756092537195 0.9355334670367836 0.04061887638923461 3.077982302221071e-08 4.1410524273252935e-09 0.03932906380975302 0.013109685983096862 9.244922431290825e-11 10.034096728399204 -0.3282439554784402 FAQPGSFEYEYAMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAQPGSFEYEYAMR 14 0 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 31765500.0 6925500.0 14022000.0 10818000.0 False True 8965196.272014197 13241663.37367137 8849235.002053596 1.0 1.4770076384168649 0.9870653952861482 23.095903737198856 -6.652288871141546 2.0001259607084774 1.3089764119230858 0.9891192636968286 0.20333743891347578 0.20347986990056033 0.5030488846792641 3.8599110725364936 0.08242748148472931 0.22544178791307068 2.2269533976228037e-07 6.652288871141546 -0.3198571482262572 FAQPGTFEFEYASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAQPGTFEFEYASR 14 0 Q8WXF1;Q8WXF1-2 Q8WXF1 PSPC1 Paraspeckle component 1 0 6649100.0 2489100.0 0.0 4160000.0 False True 2410084.8829644527 0.0 3070371.202675087 1.0 0.0 1.2739680765510917 21.2006525282588 -6.697322907597054 1.8402777737850757 0.3774472557970616 1.2700220321362403 0.4050637005357993 0.42231764859524595 0.40105228521456265 2.638615868891129 0.1832061757450199 0.4727455129207412 2.0075995626627828e-07 6.697322907597054 0.8925747763391787 FAQPGTFEFEYASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAQPGTFEFEYASR 14 0 Q8WXF1;Q8WXF1-2 Q8WXF1 PSPC1 Paraspeckle component 1 0 7521600.0 1866700.0 2811000.0 2843900.0 False True 2556869.435670704 2686800.7252660734 2172229.391959017 1.0 1.050816552375615 0.8495660207183046 21.28594706180845 -6.839793518416963 1.2834049655645712 1.0270335224222402 0.8429758094318139 0.9240913406844924 0.023542627634685852 0.16903947044421322 0.5409501543111721 0.014384722849473876 0.03313685047794506 1.4461271560687195e-07 6.839793518416963 -0.18405771299042628 FAQPGTFEFEYASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAQPGTFEFEYASR 14 0 Q8WXF1;Q8WXF1-2 Q8WXF1 PSPC1 Paraspeckle component 1 0 2489100.0 2489100.0 0.0 0.0 False True 2069796.9358266436 0.0 0.0 1.0 0.0 0.0 20.981057803693076 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 FAQPGTFEFEYASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAQPGTFEFEYASR 14 0 Q8WXF1;Q8WXF1-2 Q8WXF1 PSPC1 Paraspeckle component 1 0 12590300.0 1423700.0 5076600.0 6090000.0 False True 1843007.715322592 4794082.747309949 4981682.488676875 1.0 2.6012277145952227 2.703017707012096 20.81363067981225 -10.570664191815247 0.5337563637141368 1.2455626757390735e-12 2.6960052470776237 0.9997222529964982 0.012998044861204195 2.017845648920266 0.25626483168668746 2.744052242925299 0.019478693851698054 2.6874216292378543e-11 10.570664191815247 2.696005247076378 FASFPDYLVIQIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FASFPDYLVIQIK 13 0 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 34844100.0 15162000.0 8484100.0 11198000.0 False True 14680690.609259205 11871845.37399703 8264907.8672008775 1.0 0.8086707696509442 0.5629781382347332 23.807416501269923 -6.96771041717018 0.3080037428153429 1.0387544436304532 0.32510708877348 0.9999586142566503 0.0011507066673391863 0.07705283091377858 0.011675610236246107 0.003922927957056679 0.021855437881702036 1.0771832282640547e-07 6.96771041717018 -0.7136473548569733 FASFPDYLVIQIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FASFPDYLVIQIK 13 0 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 232404000.0 71106000.0 83246000.0 78052000.0 False True 107873000.54491735 68390100.89603326 62624987.98859316 1.0 0.6339871937422955 0.5805436733218214 26.684758578010285 -13.999999999999998 0.2709687430293671 3.8397715829072196 0.5629697194556997 0.9995854140656847 0.003795724940087549 14.930735415175105 0.16479260158962822 23.370400738696663 0.02208926987353527 1.0000000000000041e-14 13.999999999999998 -3.27680186345152 FASFPDYLVIQIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FASFPDYLVIQIK 13 0 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 27581500.0 15162000.0 5380200.0 7039300.0 False True 12607874.790487975 5351215.794713914 8511185.083954189 1.0 0.424434401803478 0.6750689727959118 23.5878217767042 -10.358447213353642 5.885881799184502 1.0000753959857787 0.5497516872997019 0.811423839421944 0.10232113513880721 0.00010125093392792975 1.103618618718901e-05 0.09908849912972871 0.03302400436313621 4.380793546160691e-11 10.358447213353642 -0.45032370868607674 FASFPDYLVIQIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FASFPDYLVIQIK 13 0 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 186321000.0 71106000.0 58835000.0 56380000.0 False True 92048118.70880672 55560780.52987839 46119418.50765216 1.0 0.6036058238804897 0.5010359706921385 26.455884900102735 -13.999999999999998 0.18979887174011367 3.1234366434116576 0.4273022562414916 0.9994895188755044 0.004861107483087902 12.347443053168385 0.13815615223713976 9.695912708743448 0.07065162005703449 1.0000000000000041e-14 13.999999999999998 -2.696134387170166 FASFPDYLVIQIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 FASFPDYLVIQIKK 14 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 82098000.0 23281000.0 27880000.0 30937000.0 True False 22541957.398375105 39012629.39227928 22833671.609894037 1.0 1.730667337482034 1.0129409441409005 24.42610945950514 -10.562966343607101 5.810746988364207 0.9989264507785383 1.3718041408114392 0.26351853535035896 0.2930105731023121 0.004086029629245621 0.0003073150994429743 0.2844665521122833 0.0945687558239954 2.7354807088439305e-11 10.562966343607101 0.37287769003290094 FASNVVEK(ub)CVTHASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FASNVVEKCVTHASR 15 1 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72;H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;H0YDK8;H0YC97;H0YDC5 A0A0C4DG68;H0YEH2 PUM2;PUM1 Pumilio homolog 2;Pumilio homolog 1 1 8554200.0 1657100.0 2907600.0 3989500.0 True False 2145148.6163244126 2745789.5040141838 3263451.9357268265 1.0 1.2799996620835223 1.5213174093823678 21.032646170711903 -6.972859233987704 0.17702950036474485 0.805940920153481 2.0018827012889173 0.9999969532013355 0.0003717870617695874 0.0753853871880038 0.005564430232430251 0.009541731196436653 0.027330349353180836 1.0644879902520255e-07 6.972859233987704 1.1959417811354363 FASPWASSPCRPQDIDFHVPSEYLTNIHIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FASPWASSPCRPQDIDFHVPSEYLTNIHIR 30 1 F8VUB4;F8VV52;F8VP97;Q9NZN8-3;Q9NZN8-2;Q9NZN8-5;Q9NZN8;H0YI11;H0YH84;Q9NZN8-4;H0YHT8;H0YI80 F8VUB4 CNOT2 CCR4-NOT transcription complex subunit 2 0 23067800.0 7583700.0 6047200.0 9436900.0 False True 11505027.342734639 4968029.913010752 7571692.578659796 1.0 0.43181382929507206 0.6581203462711698 23.455761076472434 -10.242598329811573 5.552089062690183 1.0000283714335854 0.5449670877831064 0.8435180812994523 0.09238924867638885 3.2447954856416716e-05 4.426456788615719e-06 0.08946107149431623 0.029818501791012926 5.720074302098307e-11 10.242598329811573 -0.45506128365047893 FASTMVHALNTILLTSTELFQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FASTMVHALNTILLTSTELFQLR 23 0 Q08AM6;H3BQD9;Q08AM6-2 Q08AM6 VAC14 Protein VAC14 homolog 0 67847800.0 25584000.0 34017000.0 8246800.0 False True 38812798.4409356 27946400.573965892 6616816.36529916 1.0 0.7200305491111152 0.17048027019665885 25.210029120816216 -7.223020623894129 0.5171973111562006 1.008788444674301 9.556004026518852e-22 0.9988248555985477 0.011811629716265953 0.09050913859524191 0.04268849804101433 0.012770631910163362 0.05095316229801099 5.983831782029543e-08 7.223020623894129 -1.008788444674301 down FASVLPEYLK(ub)VFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FASVLPEYLKVFK 13 1 Q86XI2;Q86XI2-2;H0Y6U5 Q86XI2 NCAPG2 Condensin-2 complex subunit G2 1 2663080.0 312960.0 743320.0 1606800.0 True False 410293.5907089508 632419.5534386665 1440543.7495139518 1.0 1.5413829700481105 3.511007196151469 18.646297092170467 -6.947055146876322 0.5902892867640056 0.9772536640736511 4.174294553545803 0.9989494561927319 0.03497181944659307 0.08469024941756205 0.041025584142536584 0.03624575694495817 0.16501978325298286 1.1296524618715272e-07 6.947055146876322 3.1970408894721514 FASVLPEYLK(ub)VFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FASVLPEYLKVFK 13 1 Q86XI2;Q86XI2-2;H0Y6U5 Q86XI2 NCAPG2 Condensin-2 complex subunit G2 1 2600130.0 312960.0 563870.0 1723300.0 True False 428669.76942599367 538956.3589312624 1316292.032477573 1.0 1.2572763403702272 3.0706434798053097 18.70950715369336 -6.9325316115118545 0.7257174780869851 0.9748480099413221 3.468104212219671 0.9970127233952704 0.050364156740068805 0.09134453558313137 0.07139723533510597 0.04659552729410015 0.16185505338728517 1.1680687051531555e-07 6.9325316115118545 2.493256202278349 up FASVLPEYLK(ub)VFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FASVLPEYLKVFK 13 1 Q86XI2;Q86XI2-2;H0Y6U5 Q86XI2 NCAPG2 Condensin-2 complex subunit G2 1 5589000.0 1241500.0 1332600.0 3014900.0 True False 1032362.2577754139 1325421.0192996094 3645301.650677411 1.0 1.2838720219738498 3.5310295617862764 19.97751787321511 -6.930292717546995 0.7443857668494852 0.9661946902498864 3.9958161863058397 0.9965953930047473 0.0660613731572635 0.09248645311345223 0.07693799228320397 0.060289830937339806 0.20300334230525913 1.1741059325020506e-07 6.930292717546995 3.0296214960559533 up FASYLTFSPSEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FASYLTFSPSEVK 13 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 27371100.0 8104000.0 10296000.0 8971100.0 False True 10624422.479247643 8759876.933493659 8042856.628867694 1.0 0.8245038213233761 0.757015889059152 23.3408810857941 -13.999999999999998 0.1323451198339437 1.8344378609092604 0.6652593540567932 0.999635129085723 0.001956232773338194 11.933813926362827 0.11335617863792802 2.585161442549941 0.08167975689299796 1.0000000000000041e-14 13.999999999999998 -1.1691785068524672 FASYLTFSPSEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FASYLTFSPSEVK 13 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 18573200.0 5906100.0 2582100.0 10085000.0 False True 5718614.088335698 3613145.995473615 7443435.956485149 1.0 0.6318219658926413 1.301615363706319 22.447234120147822 -6.75748179785042 1.6221164946727218 0.7854720130365708 1.3037485361100272 0.6805433038189452 0.15480497278526353 0.28716611134547165 1.4886659482540552 0.0753221759885292 0.18145196953695364 1.7479065191380704e-07 6.75748179785042 0.5182765230734564 FASYLTFSPSEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FASYLTFSPSEVK 13 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 24304900.0 0.0 15031000.0 9273900.0 False True 0.0 12348600.612260979 7440909.600105233 0.0 FASYLTFSPSEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FASYLTFSPSEVK 13 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 23997200.0 8104000.0 7556600.0 8336600.0 False True 11100267.802365342 7222724.4256654475 6367666.777666422 1.0 0.6506801956729699 0.5736498335931628 23.40409114731699 -13.999999999999998 0.2124440676425732 3.040812181888016 0.5293395808449183 0.9994915238213854 0.004183184343293995 12.805058979373936 0.14607401983983068 10.920933382755198 0.04486018199059103 1.0000000000000041e-14 13.999999999999998 -2.511472601043098 FASYLTFSPSEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FASYLTFSPSEVK 13 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 14529100.0 5906100.0 3307000.0 5316000.0 False True 4911183.834593133 3289184.534611892 6427551.021593124 1.0 0.6697335398939275 1.30875797731681 22.2276393955821 -6.766237169246915 1.5886860217019985 0.809650737747778 1.3118628582541698 0.715946391180619 0.13906696671614857 0.272599667239729 1.3571976488186615 0.06901915779555595 0.16487933017038914 1.7130215668848354e-07 6.766237169246915 0.5022121205063919 FATEAAITILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FATEAAITILR 11 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 14816900.0 3698500.0 5227100.0 5891300.0 False True 4848769.316324949 4447237.055076216 5281724.789340017 1.0 0.917188829772362 1.0892918274246175 22.209187187440634 -6.775910915699848 1.5522437613707694 0.9528599474523015 1.0904737346522977 0.7524894880307975 0.034963285771785806 0.25698810486118545 1.222790793708868 0.017747675439067887 0.042014796305033894 1.6752864825528237e-07 6.775910915699848 0.13761378719999617 FATEAAITILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FATEAAITILR 11 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 29869700.0 12701000.0 6806700.0 10362000.0 False True 12297813.707175903 9524650.806471566 7647881.346663282 1.0 0.7744995194482278 0.6218895105071126 23.55189852171347 -7.986848538171174 0.08676026800635961 1.5475178501881943 0.00028241769600982766 0.999994599333506 0.00036089810062644724 0.11068111571724688 0.013988884431539002 0.11333350521492287 0.12724592217685857 1.030745534134051e-08 7.986848538171174 -1.5472354324921844 FATEAAITILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FATEAAITILR 11 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 168951000.0 35854000.0 72261000.0 60836000.0 False True 54393139.27850626 59365459.97223008 48811737.934633926 1.0 1.0914144827762986 0.8973877695255981 25.696921356990956 -6.778635356484032 1.5416521834957604 1.0518540561390397 0.8959287522579108 0.7623641800894296 0.03863516774225615 0.2527072649156453 1.186296564829418 0.019742258909697327 0.04662784017250387 1.664809875920095e-07 6.778635356484032 -0.1559253038811289 FATEAAITILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FATEAAITILR 11 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 17708200.0 3698500.0 5942900.0 8066800.0 False True 5065935.398204369 5680323.027457749 6161587.9809610015 1.0 1.121278220300865 1.2162784355965117 22.272397248963525 -6.973865913533002 0.1373966258633719 0.8679026877255004 1.472126749170559 0.9999990048695462 8.810754719689165e-05 0.07506712495539049 0.004151200612389132 0.00551880495483606 0.012521021788678628 1.0620234015320934e-07 6.973865913533002 0.6042240614450586 FATEAAITILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FATEAAITILR 11 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 26351900.0 12701000.0 6283200.0 7367700.0 False True 10561444.24970239 6249351.154482451 8908252.005604144 1.0 0.5917136905455475 0.8434691122717586 23.332303797147745 -10.341340354386455 6.015906457640399 1.0000307923688425 0.7175914014086529 0.6265573443655603 0.10277872053473554 4.2451833957045176e-05 4.647933876702558e-06 0.09952590114083024 0.033171689414627954 4.556796621366562e-11 10.341340354386455 -0.28243939096018966 FATEAAITILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FATEAAITILR 11 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 123872000.0 35854000.0 53787000.0 34231000.0 False True 46413709.78800039 50793706.16742709 28001309.239720505 1.0 1.0943685906477376 0.6032982359656123 25.468047679083405 -6.856908520273736 1.2012346567866066 1.0508375653792241 0.5808819695459277 0.9497738140408306 0.04768361569616191 0.1500200661385199 0.4131100642537004 0.03099682714182861 0.07212342847804765 1.390245441470341e-07 6.856908520273736 -0.4699555958332964 FATHAAALSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FATHAAALSVR 11 0 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 216616000.0 98505000.0 87741000.0 30370000.0 False True 129141008.92377703 74650384.81173934 27227603.729610845 1.0 0.5780532879048536 0.21083623208861105 26.94437196250358 -7.791999165236463 0.3264923484242139 1.0884097392451337 1.047852516214611e-12 0.9991528399382754 0.00938473514514654 0.11756581384479453 0.05271995619924181 0.03851302893740333 0.08111171389665471 1.6143616598107737e-08 7.791999165236463 -1.088409739244086 down FATHAAALSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FATHAAALSVR 11 0 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 65103500.0 47970500.0 17133000.0 0.0 False True 46447702.73522414 23974296.24741471 0.0 1.0 0.5161567706390251 0.0 25.469103908086236 -7.879599545506165 0.6030408411928178 1.0081392839851715 4.490718282030621e-18 0.9886227414631819 0.0435530677270533 0.11387104632980193 0.1593734166670823 0.04417724086064632 0.07742489867504788 1.3194728380368762e-08 7.879599545506165 -1.0081392839851715 down FATHAAALSVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FATHAAALSVR 11 0 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 250508000.0 81668000.0 103910000.0 64930000.0 False True 123896326.73054755 85366448.64746444 52096557.04017005 1.0 0.6890151701843531 0.42048508147841046 26.884558174291858 -7.241803539494469 0.20196538403815173 1.1740340135052847 2.2667544352171592e-13 0.9999837446638542 0.000954700507353472 0.09779272528151314 0.010734328357537215 0.01593669232748866 0.04140509138981665 5.730552036421261e-08 7.241803539494469 -1.174034013505058 down FATHAAALSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FATHAAALSVR 11 0 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 210388600.0 98505000.0 51669600.0 60214000.0 False True 134924960.49753186 49386666.22348197 45992693.346257016 1.0 0.3660306146569921 0.34087609273080605 27.007582024026473 FATHAAALSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FATHAAALSVR 11 0 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 111927500.0 47970500.0 36247000.0 27710000.0 False True 39889596.203476004 36051730.21653378 33504032.88343592 1.0 0.9037877955102541 0.8399190784617759 25.249509183520512 FATHAAALSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FATHAAALSVR 11 0 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 235504000.0 81668000.0 93055000.0 60781000.0 False True 105720835.9169526 87876407.44808085 49719481.66572559 1.0 0.8312118106700446 0.4702902813290464 26.655684496384307 -6.958716320683213 0.45316509745587424 1.0112697307345302 0.2758485396416305 0.9997195785796643 0.0036998766119617807 0.08016293581826173 0.022850221171662556 0.004847402585678105 0.029840714996169707 1.0997239398982335e-07 6.958716320683213 -0.7354211910928997 down FATHGAALTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FATHGAALTVK 11 0 Q8WXF1;Q8WXF1-2;X6RDA4 Q8WXF1 PSPC1 Paraspeckle component 1 0 25479300.0 10877000.0 7067000.0 7535300.0 False True 14259852.333017843 6012631.146950237 6755619.439701556 1.0 0.42164750423315017 0.4737510096131444 23.76545570633514 -10.465074162704886 9.480459940459454 1.0000046863275693 0.44769925804369515 0.9933693715842636 0.021271166998557363 2.1069568920682783e-06 1.1888767451707593e-07 0.020595893449094918 0.006865239628317466 3.427092584810581e-11 10.465074162704886 -0.5523054282838742 FATHGAALTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FATHGAALTVK 11 0 Q8WXF1;Q8WXF1-2;X6RDA4 Q8WXF1 PSPC1 Paraspeckle component 1 0 15647400.0 4396700.0 2073200.0 9177500.0 False True 4257129.165131899 2901039.5715951747 6773637.430901585 1.0 0.6814544400851629 1.5911280039095825 22.02144943277437 -6.812085319939691 1.4056395342894463 0.8268150923119572 1.6078299118308208 0.8652242336915067 0.13836290085959368 0.20397295756348321 0.7938848425950009 0.07738840415293916 0.1788614150072113 1.541397605745018e-07 6.812085319939691 0.7810148195188636 FATHGAALTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FATHGAALTVK 11 0 Q8WXF1;Q8WXF1-2;X6RDA4 Q8WXF1 PSPC1 Paraspeckle component 1 0 20140800.0 6612000.0 8859700.0 4669100.0 False True 10030887.401949115 7278617.313847948 3746250.3384607723 1.0 0.7256204782473812 0.37347147748192583 23.257945906628198 -6.9677187944681735 0.30784130786161834 1.0556531888397291 0.0322798938639928 0.9999587214419178 0.0016475446906238222 0.07705010510295433 0.01166619578709006 0.00562691071599702 0.03133021039018601 1.0771624502016086e-07 6.9677187944681735 -1.0233732949757364 down FATHGAALTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FATHGAALTVK 11 0 Q8WXF1;Q8WXF1-2;X6RDA4 Q8WXF1 PSPC1 Paraspeckle component 1 0 22642200.0 10877000.0 4197100.0 7568100.0 False True 14898520.839872634 4011658.2440463244 5780670.649912101 1.0 0.2692655389862595 0.3880029911722109 23.82866576785803 -9.971542981171545 5.850882892913256 1.0000006450265781 0.32863426510553534 0.9770782525001517 0.04847436186974845 4.0792537951190404e-07 7.160182798679652e-08 0.046935144516090384 0.01564503301984724 1.0677191174926849e-10 9.971542981171545 -0.6713663799210428 FATHGAALTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FATHGAALTVK 11 0 Q8WXF1;Q8WXF1-2;X6RDA4 Q8WXF1 PSPC1 Paraspeckle component 1 0 12024800.0 4396700.0 5405300.0 2222800.0 False True 3656050.8568354035 5376180.57603196 2687577.2029340137 1.0 1.4704884550444854 0.7351038889159001 21.801854708208648 -6.733859720935447 1.70885541276552 1.2819029491735534 0.7351962521351711 0.5772407835558739 0.19772901339854257 0.329026872578074 1.8839569504143474 0.09162492147976903 0.22640050102576054 1.8456114636882274e-07 6.733859720935447 -0.5467066970383823 FATHGAALTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FATHGAALTVK 11 0 Q8WXF1;Q8WXF1-2;X6RDA4 Q8WXF1 PSPC1 Paraspeckle component 1 0 19257700.0 6612000.0 8071100.0 4574600.0 False True 8559364.34200532 7621936.189932886 3742069.739359801 1.0 0.8904792324972102 0.43719014518350263 23.029072228720647 -6.94409153013766 0.6203346252242963 1.0049599640737377 0.2986812768078778 0.9986521647591466 0.008944527959861759 0.08594869806725178 0.046475437396356685 0.00900507192939169 0.03836682475230475 1.1373875493900288e-07 6.94409153013766 -0.7062786872658599 down FATLAELVQYYMEHHGQLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 FATLAELVQYYMEHHGQLK 19 0 Q06124;Q06124-1;A0A1W2PPU4;Q06124-3 Q06124 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 0 484976800.0 211949800.0 77729800.0 195297200.0 False True 205221569.61445493 108767714.49555196 144143004.52958596 1.0 0.530001377047702 0.7023774586676446 27.612607131079038 -10.05086591004267 4.946467023608706 1.0000077491928245 0.6161894178544278 0.8685984637405515 0.07037224064943422 6.014013021819285e-06 1.1538334626781665e-06 0.06813900425301686 0.022712543004275474 8.894757042356496e-11 10.05086591004267 -0.3838183313383967 FATLAELVQYYMEHHGQLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 FATLAELVQYYMEHHGQLK 19 0 Q06124;Q06124-1;A0A1W2PPU4;Q06124-3 Q06124 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 0 144970500.0 48628200.0 39422200.0 56920100.0 False True 73772534.59761982 32387000.40294554 45669817.28603391 1.0 0.4390116264758303 0.6190626028390164 26.136580467287054 -10.519997650115949 6.9401028442667805 1.0002196448424028 0.5290371146574252 0.901211665154751 0.07350550329662012 0.0002499227470975013 1.7285577098490274e-05 0.07120370934480451 0.023723799176867018 3.019968060825112e-11 10.519997650115949 -0.4711825301849776 FATLAELVQYYMEHHGQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FATLAELVQYYMEHHGQLK 19 0 Q06124;Q06124-1;A0A1W2PPU4;Q06124-3 Q06124 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 0 452036700.0 211949800.0 91813900.0 148273000.0 False True 176245649.66818145 91319280.29706769 179276198.76310697 1.0 0.518136365175509 1.017195029214231 27.393012406513314 -10.934778394859823 12.005241708570464 1.0382923659659695 0.7676656971948873 0.22419053839420755 0.20373984643498766 0.11483192103737684 0.000623853344712232 0.1084833610877314 0.06575675268346365 1.1620414112888514e-11 10.934778394859823 -0.2706266687710822 FATLAELVQYYMEHHGQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FATLAELVQYYMEHHGQLK 19 0 Q06124;Q06124-1;A0A1W2PPU4;Q06124-3 Q06124 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 0 90433500.0 38053000.0 32748500.0 19632000.0 False True 49260358.6367708 30926017.1867549 16059177.44133076 1.0 0.6278073900109594 0.3260061007623939 25.553923795532114 -7.686040751706206 0.2371903602067779 1.1631375983444883 3.208426800940056e-21 0.9998248175746117 0.0036484898748520202 0.12937177477087586 0.030328463251227365 0.04123834076507564 0.07938966107520995 2.0604365646353323e-08 7.686040751706206 -1.1631375983444883 down FAVALDSEQNNIHVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAVALDSEQNNIHVK 15 0 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 13878400.0 4349100.0 5102300.0 4427000.0 False True 5701712.216744312 4341056.728609628 3968936.506782589 1.0 0.7613601956025026 0.6960955509341471 22.44296379310487 -13.999999999999998 0.18193153175467472 2.245633861958517 0.6452732877209129 0.9994959342409657 0.002932712737893021 12.23032596447364 0.13523002673752207 5.387782624304455 0.04794059641598263 1.0000000000000041e-14 13.999999999999998 -1.6003605742376044 FAVALDSEQNNIHVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAVALDSEQNNIHVK 15 0 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 10450300.0 2507000.0 2100700.0 5842600.0 False True 2427416.6572624194 2939520.465005781 4312247.785757084 1.0 1.2109665871374962 1.7764761450637532 21.21099033243793 -6.953950519079529 0.5136460055266887 0.9898964935270497 2.02251074880354 0.9994759481627361 0.007504626548852564 0.08193713363486893 0.029689385736460638 0.008590440438990737 0.046685181644850825 1.1118583985733555e-07 6.953950519079529 1.0326142552764903 FAVALDSEQNNIHVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAVALDSEQNNIHVK 15 0 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 12951500.0 4349100.0 3263800.0 5338600.0 False True 5957079.800008279 3119594.5240567056 4077732.6319182822 1.0 0.5236784848932811 0.6845187187038547 22.50617385462776 -10.404840324522224 6.350850092027377 1.0000657381012212 0.604098601798568 0.8898479934752359 0.06566275049097481 6.112822757320411e-05 5.728534952642235e-06 0.06358818237873708 0.021192561593143176 3.936947971883666e-11 10.404840324522224 -0.39596713630265323 FAVGIVIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAVGIVIGR 9 0 Q96I24;Q96I24-2;Q96AE4;E9PEB5;Q96AE4-2 Q96I24;Q96AE4;Q96AE4-2 FUBP3;FUBP1 Far upstream element-binding protein 3;Far upstream element-binding protein 1 0 24127400.0 7131900.0 10130000.0 6865500.0 False True 9349989.965417849 8618643.486430733 6155123.918526282 1.0 0.9217810412960766 0.6583027298737011 23.15653338599828 -6.948822286739234 0.5716354944049096 1.003258372363329 0.5639794389354119 0.9991055246689005 0.004371673639728605 0.083962312353892 0.037947646214376844 0.004622926553316384 0.02196176814799727 1.1250652563828496e-07 6.948822286739234 -0.43927893342791713 FAVGIVIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAVGIVIGR 9 0 Q96I24;Q96I24-2;Q96AE4;E9PEB5;Q96AE4-2 Q96I24;Q96AE4;Q96AE4-2 FUBP3;FUBP1 Far upstream element-binding protein 3;Far upstream element-binding protein 1 0 114915000.0 58341000.0 24156000.0 32418000.0 False True 56488996.889248855 33801616.77187584 23926753.28084637 1.0 0.5983752347053813 0.4235648462258351 25.7514665462664 -13.999999999999998 0.11319031029866301 2.9281599888746337 0.11712291139264021 0.9997268995244507 0.00398806836938538 11.994827502575077 0.1025992762638526 5.255799753490466 0.27201013350226316 1.0000000000000041e-14 13.999999999999998 -2.8110370774819935 FAVGIVIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAVGIVIGR 9 0 Q96I24;Q96I24-2;Q96AE4;E9PEB5;Q96AE4-2 Q96I24;Q96AE4;Q96AE4-2 FUBP3;FUBP1 Far upstream element-binding protein 3;Far upstream element-binding protein 1 0 1192610000.0 321070000.0 443620000.0 427920000.0 False True 487086663.3611316 364452544.9811203 343341424.4360008 1.0 0.7482293653170935 0.7048877546077331 28.85960324121759 -13.99999999930364 0.24751818188494845 2.7292827189271267 0.6870446845658832 0.9995380849183726 0.00279635166362848 13.901041695039575 0.15743571983705817 11.934504964878867 0.020281796091788932 1.0000000016034289e-14 13.99999999930364 -2.0422380343612434 FAVGIVIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAVGIVIGR 9 0 Q96I24;Q96I24-2;Q96AE4;E9PEB5;Q96AE4-2 Q96I24;Q96AE4;Q96AE4-2 FUBP3;FUBP1 Far upstream element-binding protein 3;Far upstream element-binding protein 1 0 55248900.0 7131900.0 18833000.0 29284000.0 False True 9768756.162350614 18000895.78759728 22367722.322911426 1.0 1.8427009015716698 2.289720610400534 23.21974344752117 -9.454096901149605 0.1727836220089658 7.774028944352441e-22 2.8557386396823237 0.9996662709629252 0.009768438664171916 0.8964361134748456 0.06790322585954454 0.762951203528872 0.3087557626817649 3.514820080083835e-10 9.454096901149605 2.8557386396823237 FAVGIVIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FAVGIVIGR 9 0 Q96I24;Q96I24-2;Q96AE4;E9PEB5;Q96AE4-2 Q96I24;Q96AE4;Q96AE4-2 FUBP3;FUBP1 Far upstream element-binding protein 3;Far upstream element-binding protein 1 0 108936000.0 58341000.0 21245000.0 29350000.0 False True 48513126.44452307 21130548.968197674 35486949.30093267 1.0 0.43556353747601495 0.7314916992932539 25.531871821700676 -10.058547419624016 5.177545545563212 1.000005561252223 0.5835276183835635 0.7253364876353832 0.12081216616573624 7.755591120235806e-06 1.410309558658457e-06 0.11697743817175761 0.03899195896439108 8.738815702455505e-11 10.058547419624016 -0.41647794286865947 FAVGIVIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAVGIVIGR 9 0 Q96I24;Q96I24-2;Q96AE4;E9PEB5;Q96AE4-2 Q96I24;Q96AE4;Q96AE4-2 FUBP3;FUBP1 Far upstream element-binding protein 3;Far upstream element-binding protein 1 0 1018190000.0 321070000.0 373120000.0 324000000.0 False True 415631444.23588145 352355544.00116026 265035324.5207398 1.0 0.8477595929945798 0.6376690892769064 28.63072956331004 -6.966606333961967 0.32932849136418213 1.0257969580013273 0.45276110326742985 0.9999425225153132 0.0011261864057829332 0.07742008757894663 0.012960842951380417 0.003072928543822427 0.018334497642266443 1.0799251763941965e-07 6.966606333961967 -0.5730358547338974 FAVLHGEAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FAVLHGEAPR 10 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 4575190.0 514890.0 2609300.0 1451000.0 False True 675025.7762018536 2220002.610971739 1300864.4389748226 1.0 3.288767168956063 1.9271329848977854 19.36458306769446 -10.255575878038195 5.986164519571483 0.9999437623453508 2.60795007692693 0.6502711184056517 0.5558848278789694 0.00041723155440156296 5.188624571946844e-05 0.5382516661101238 0.17941105673204905 5.5516761218120384e-11 10.255575878038195 1.608006314581579 FAVLHGEAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FAVLHGEAPR 10 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 3851360.0 921220.0 506340.0 2423800.0 False True 891976.3753503335 708524.2025282171 1788934.0675586234 1.0 0.7943306819644594 2.005584583847302 19.76664597425025 -6.863186419279411 1.1694370538589467 0.8873087537101291 2.0679378765541716 0.9574025508440951 0.10922589931061757 0.14356064746341382 0.37125950692590987 0.07274406250416998 0.17047375499554487 1.3702934465783218e-07 6.863186419279411 1.1806291228440426 up FAVLHGEAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FAVLHGEAPR 10 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 3941190.0 514890.0 1634100.0 1792200.0 False True 705258.7473790591 1561900.0587539272 1368919.271517616 1.0 2.214648261447858 1.9410170757965173 19.427793129217353 -10.04271542527592 4.556213473358532 0.99995502203925 2.0778326686796507 0.9538907150946008 0.1117094639821323 19329602.343692057 1.178072844770713 9506.075533186904 0.03824112078538141 9.063262834800363e-11 10.04271542527592 1.0778776466404008 FAVSIGYWHDPYIQHFVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FAVSIGYWHDPYIQHFVR 18 0 Q9UIC8-3;Q9UIC8;Q9UIC8-2;H3BUP7;I3L2Q8 Q9UIC8-3 LCMT1 Leucine carboxyl methyltransferase 1 0 206742000.0 42367000.0 82220000.0 82155000.0 False True 64273836.44258587 67547198.61220792 65917028.2401844 1.0 1.0509283769383528 1.0255654849398377 25.93772825221554 -10.199925365907228 4.738312624678689 0.9999938113938276 1.0382469309392666 0.7519862927030909 0.01035435730020181 6.770307622691733e-07 1.1432829631549682e-07 0.010027185530606731 0.003341854448613453 6.310657846688138e-11 10.199925365907228 0.038253119545438974 FAVSIGYWHDPYIQHFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FAVSIGYWHDPYIQHFVR 18 0 Q9UIC8-3;Q9UIC8;Q9UIC8-2;H3BUP7;I3L2Q8 Q9UIC8-3 LCMT1 Leucine carboxyl methyltransferase 1 0 190724000.0 42367000.0 74732000.0 73625000.0 False True 54844916.67842394 70573098.50529234 60226005.45629472 1.0 1.286775562429761 1.0981146312870178 25.70885457430799 -10.229099092301178 3.673200846840507 0.9997215783380218 1.1924450967540088 0.581126882560189 0.0770205031835604 54727452.456190124 136508968.07533905 199489.96859445985 0.028186606233795628 5.900664302649483e-11 10.229099092301178 0.192723518415987 FCADCQSK(ub)GPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FCADCQSKGPR 11 1 Q8WU79 Q8WU79 SMAP2 Stromal membrane-associated protein 2 1 4387700.0 941300.0 1235600.0 2210800.0 True False 1428020.918247839 1015097.5262131366 1773834.4109719382 1.0 0.7108421965265374 1.242162764077999 20.4455856820465 -6.75889306527304 1.6164420486710551 0.8318140707617755 1.2440126246867123 0.6865329772921721 0.12160248923905118 0.2847680545432783 1.466196643094653 0.05936090201925841 0.14282103693035408 1.742235804872625e-07 6.75889306527304 0.41219855392493676 FCADCQSK(ub)GPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FCADCQSKGPR 11 1 Q8WU79 Q8WU79 SMAP2 Stromal membrane-associated protein 2 1 4388330.0 941300.0 937930.0 2509100.0 True False 1218531.4057969777 885733.3709932665 2052469.5455400886 1.0 0.7268859602465105 1.6843796850666115 20.216712004138948 -6.830496912276949 1.3259254957589952 0.8541223387818409 1.7103637345188891 0.9068190371168094 0.12293717517248048 0.18020175554646717 0.6194580632098228 0.07279926105890178 0.16750868749485437 1.4774169856104e-07 6.830496912276949 0.8562413957370483 FCADHPFLFFIQHSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FCADHPFLFFIQHSK 15 0 A0A2R8YD12;A0A024QZX5;A0A087X1N8;P35237 A0A2R8YD12 SERPINB6 Serpin B6 0 7827900.0 2202400.0 3147200.0 2478300.0 False True 2887367.7280719425 2677650.0276895138 2221869.289532253 1.0 0.9273671661757926 0.769513792071064 21.46132342670116 -6.958387508141232 0.4575932902834264 1.004713401950674 0.6858298037083611 0.9997056354299064 0.0016507676617505092 0.08028225118451446 0.023298246103256565 0.0021351987243871796 0.013043850691830517 1.1005568769076047e-07 6.958387508141232 -0.31888359824231294 FCADHPFLFFIQHSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FCADHPFLFFIQHSK 15 0 A0A2R8YD12;A0A024QZX5;A0A087X1N8;P35237 A0A2R8YD12 SERPINB6 Serpin B6 0 16860800.0 5193900.0 3928100.0 7738800.0 False True 7879526.024952132 3227099.864614615 6209222.787963467 1.0 0.4095550740482794 0.7880198337185119 22.909677419562055 -10.112507717689164 5.427532021180507 1.0000061161981424 0.5987874538832731 0.5997488594567868 0.15450759113674972 1.143506819037846e-05 1.8698913714640402e-06 0.14960361257949142 0.04986711061119021 7.71777800480768e-11 10.112507717689164 -0.40121866231486925 FCADHPFLFFIQHSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FCADHPFLFFIQHSK 15 0 A0A2R8YD12;A0A024QZX5;A0A087X1N8;P35237 A0A2R8YD12 SERPINB6 Serpin B6 0 12117500.0 2202400.0 4225500.0 5689600.0 False True 3016686.797622093 4038803.4381400845 4345833.660990202 1.0 1.3388209347167483 1.4405982299573858 21.52453348822405 -12.50175460494771 0.18988123362007586 3.092182779383004e-10 1.5192293767237552 0.9994441069279358 0.00444082129626218 6.649184420536278 0.12643463503448676 2.6048840734433214 0.06974999804791428 3.149527429809367e-13 12.50175460494771 1.519229376414537 FCADHPFLFFIQHSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FCADHPFLFFIQHSK 15 0 A0A2R8YD12;A0A024QZX5;A0A087X1N8;P35237 A0A2R8YD12 SERPINB6 Serpin B6 0 20463100.0 5193900.0 6819700.0 8449500.0 False True 6723605.937075231 6440177.700001905 6911777.699191339 1.0 0.9578457988576562 1.0279867326962893 22.680803741654504 -6.7439737236324655 1.6722193308625057 0.9750341292315362 1.0280638378905576 0.6225901666744088 0.01771069830284266 0.31068641554083354 1.707303055861862 0.008373765809070448 0.02045895047031523 1.8031268331738044e-07 6.7439737236324655 0.053029708659021346 FCANTCVECR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FCANTCVECR 10 0 Q13642;A0A0D9SFZ9;Q5JXI8;A0A494C0D6;Q5JXI2;Q5JXI3;Q5JXH7;Q5JXH8;Q5JXH9;A0A0D9SFB0;A0A0D9SFI6;Q5JXI0;A0A0D9SGB2;Q13642-3;Q13642-1;Q13642-5;Q13642-4;A0A494C0J3;A0A0D9SGD1;A0A0D9SEY7 Q13642 FHL1 Four and a half LIM domains protein 1 0 2986910.0 884460.0 1121400.0 981050.0 False True 1159535.625122825 954091.4911829629 879540.3568961044 1.0 0.8228220595481056 0.7585281019743901 20.145115714791906 -13.999999999999998 0.1410213981483995 1.847143595543004 0.679931621310676 0.9995988902666537 0.002044982926777833 11.93522527377189 0.11773049656438354 2.7807507031543692 0.07031383991638482 1.0000000000000041e-14 13.999999999999998 -1.1672119742323281 FCDNSSAIQGK(ub)EVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FCDNSSAIQGKEVR 14 1 O15067 O15067 PFAS Phosphoribosylformylglycinamidine synthase 1 55127600.0 6102800.0 7383800.0 41641000.0 True False 9258393.774442686 6066103.2001072895 33410638.098101303 1.0 0.65520038873832 3.6086862270137647 23.14233049340942 -6.8778044269548975 1.0919277288312 0.7918960317457071 3.8094163372778618 0.9718728059648091 0.22113648097983732 0.12959476141899007 0.2841654038736162 0.1562963066370436 0.3759574153061541 1.324938051716258e-07 6.8778044269548975 3.0175203055321544 up FCDNSSAIQGK(ub)EVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FCDNSSAIQGKEVR 14 1 O15067 O15067 PFAS Phosphoribosylformylglycinamidine synthase 1 33553600.0 6102800.0 4765800.0 22685000.0 True False 7900194.904172724 4500579.040525106 18556562.76775613 1.0 0.5696794946347451 2.3488740458738464 22.91345681550187 -6.842816603588963 1.269264422521166 0.771099367811612 2.410727411635321 0.9291879344962357 0.2016901995035766 0.16553398381757262 0.5168098223290472 0.1245398179613468 0.2871670738003952 1.4360957482280192e-07 6.842816603588963 1.639628043823709 up FCEVPACK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FCEVPACKR 9 1 Q13415 Q13415 ORC1 Origin recognition complex subunit 1 1 3029690.0 1160800.0 603990.0 1264900.0 True False 1589979.1294404825 577303.7246721644 966156.671433229 1.0 0.3630888695220289 0.6076536814500338 20.60057639769523 -10.26941229201329 5.612753457766572 1.0000408211597334 0.4853712754860609 0.8551542894483055 0.09984316637726262 5.100526395655723e-05 6.63915154957058e-06 0.0966803696494996 0.03222424338430731 5.377590253357166e-11 10.26941229201329 -0.5146695456736725 FCFTPHTEEGCLSER ddPTM_RPMI8226_Bortezomib_1h_R1 1 FCFTPHTEEGCLSER 15 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 21696700.0 1530300.0 12930000.0 7236400.0 False True 2006238.119446278 11000894.400745247 6487646.744450313 1.0 5.483344321949926 3.233737152916277 20.936061418223694 -9.249704077705037 9.101053185040785 0.9999999999999878 4.35854073741835 0.7482280331241291 0.9183982809790382 0.0 0.0 0.8892353118517247 0.2964117706172415 5.627246274192204e-10 9.249704077705037 3.3585407374183625 FCFTPHTEEGCLSER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FCFTPHTEEGCLSER 15 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 13123300.0 1530300.0 5533900.0 6059100.0 False True 2096093.264802524 5289393.999839888 4628065.371081567 1.0 2.5234535546004007 2.2079482095552576 20.999271479746586 -10.52255674865925 5.214167929107414 0.995575275196729 2.3657008820778334 0.9615126057143362 0.12880451774693022 0.006627886238433325 0.000606891881544436 0.12476352201825784 0.0415714793458392 3.0022250986286545e-11 10.52255674865925 1.3701256068811043 FCGLMVQLLHK ddPTM_RPMI8226_Bortezomib_1h_R1 2 FCGLMVQLLHK 11 0 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 0 112396900.0 39045900.0 45883100.0 27467900.0 False True 51189553.02103346 39037520.33092303 24625785.19870194 1.0 0.7626071732816804 0.48107052602282663 25.60934607321413 -6.96886684352747 0.28394827332505135 1.0591482015937062 0.17590384443775797 0.9999721453458819 0.0011194352552483299 0.07667213550641937 0.010340020042408533 0.005084861724484519 0.025715243128953232 1.0743187523936767e-07 6.96886684352747 -0.8832443571559482 down FCGLMVQLLHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FCGLMVQLLHK 11 0 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 0 46288700.0 27502000.0 14791100.0 3995600.0 False True 26628964.063833725 20697263.36456754 2949032.494569369 1.0 0.7772462839693282 0.11074529551732033 24.666492969251234 -7.175722332507848 0.6568185598961578 0.9992011143212733 3.0625715944922293e-22 0.9973141899895483 0.019579570230503038 0.08490707943708196 0.06320551816881483 0.018470160667159556 0.053960607198952716 6.672332304558844e-08 7.175722332507848 -0.9992011143212733 down FCGLMVQLLHK ddPTM_RPMI8226_Bortezomib_8h_R1 2 FCGLMVQLLHK 11 0 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 0 464209600.0 124985600.0 183400000.0 155824000.0 False True 189612292.8713023 150670837.08925986 125025318.09991463 1.0 0.7946258905878343 0.6593734836842803 27.49847725861758 -8.62409262213903 0.07150570875159948 1.6761754830850737 1.537485207348385e-07 0.9999935106975284 0.00035669002429552626 0.21254075630309022 0.01861039697450546 0.22503696915875268 0.2007614389911596 2.3763334310998934e-09 8.62409262213903 -1.6761753293365529 FCGLMVQLLHK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FCGLMVQLLHK 11 0 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 0 214537100.0 39045900.0 59482200.0 116009000.0 False True 53482224.40577203 56854079.722668655 88610063.48035224 1.0 1.0630462804111176 1.6568133518169275 25.67255613473702 -6.9271918327404505 0.7694819347087911 0.9899690163536918 1.7704331007516467 0.9959573209216482 0.01881305680565829 0.09412168869535606 0.08501349549249444 0.01686174070590505 0.054578402897798486 1.1825191084037819e-07 6.9271918327404505 0.7804640843979549 FCGLMVQLLHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FCGLMVQLLHK 11 0 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 0 54839700.0 27502000.0 3978200.0 23359500.0 False True 22869131.54517877 3956768.646989121 28243863.44787522 1.0 0.1730178795452895 1.2350212508978962 24.44689824468551 -6.698889327859347 1.8345558289891772 0.48591275642252085 1.2318199674698749 0.4123313506014371 0.3491527669749103 0.3978926251172325 2.6026463796539114 0.1518681665426193 0.391141045033777 2.0003715634156478e-07 6.698889327859347 0.745907211047354 FCGLMVQLLHK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FCGLMVQLLHK 11 0 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 0 427979300.0 124985600.0 174886900.0 128106800.0 False True 161796323.0345039 165154290.27705944 104792676.88677007 1.0 1.0207542864978423 0.6476826847568253 27.26960358071003 -6.893732719625113 1.0000178105911899 1.018288863051383 0.6131437605540426 0.9831826026143702 0.022199677276337208 0.11616762201743122 0.2045643670905883 0.016825985517827477 0.042553186839773306 1.2772246167419234e-07 6.893732719625113 -0.4051451024973405 FCIWTESAFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FCIWTESAFR 10 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 53437000.0 15178000.0 21234000.0 17025000.0 False True 19898504.983961098 18065969.969483733 15263416.315331737 1.0 0.9079058946411073 0.7670634717349164 24.246156706375046 -6.964933567690411 0.35919392564706826 1.0122486971818114 0.6579002289707353 0.9999117619633393 0.0008997630707400255 0.0779835450658106 0.014939705207371819 0.0018927324779743617 0.012035540358702222 1.0840927307169643e-07 6.964933567690411 -0.35434846821107613 FCIWTESAFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FCIWTESAFR 10 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 30784900.0 20605000.0 5441100.0 4738800.0 False True 19950905.553606767 7613759.604961652 3497566.1190472837 1.0 0.3816247630717304 0.17530863998376184 24.249950894771853 -12.32667720753066 0.17960763826351275 2.730181658826246 3.563406252935431e-23 0.9994658644127506 0.008098401593291185 6.198156871692044 0.12053817774285483 4.060149717694499 0.1518435837101687 4.713275137754514e-13 12.32667720753066 -2.730181658826246 FCIWTESAFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FCIWTESAFR 10 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 183364000.0 46322000.0 76765000.0 60277000.0 False True 70273860.59181584 63065685.982317425 48363224.52965235 1.0 0.89742737130429 0.6882107247610753 26.06648482139968 -6.9596585985746415 0.4402185471649992 1.0074636732453806 0.5700144042405512 0.9997573260840442 0.0020211681132022725 0.07982329389884765 0.021583605642632866 0.0027591468247510024 0.017334191201262013 1.0973404829285951e-07 6.9596585985746415 -0.4374492690048294 FCIWTESAFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FCIWTESAFR 10 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 59184000.0 15178000.0 18648000.0 25358000.0 False True 20789716.770027295 17824069.69931044 19368962.66440337 1.0 0.8573502898802137 0.9316607281695999 24.309366767897938 -10.193426921672208 4.489359860211013 1.0000252483313081 0.8945055090231041 0.7287908786994699 0.030337109401388306 42625177.02770821 0.3019447875430905 11124.992477684895 0.01038519946698897 6.405795622270534e-11 10.193426921672208 -0.10551973930820402 FCIWTESAFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FCIWTESAFR 10 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 35453400.0 20605000.0 2281400.0 12567000.0 False True 17133970.456272565 2269109.6453775554 15194701.596757118 1.0 0.13243338146102956 0.8868173104147322 24.03035617020613 -10.66074511615353 10.459374597905892 1.0001387184094235 0.509625345937881 0.36036474845155353 0.3079759493487614 0.000996498767771141 3.2321902683330344e-05 0.29827745533253186 0.09939881023834762 2.184011313995933e-11 10.66074511615353 -0.4905133724715425 FCIWTESAFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FCIWTESAFR 10 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 181512000.0 46322000.0 78149000.0 57041000.0 False True 59964742.143129155 73799939.45150784 46660123.29008492 1.0 1.230722201312158 0.7781259724041238 25.83761114349213 -6.768155814319312 1.5818164519556015 1.13264892014841 0.775773891690591 0.7233510373839283 0.09719132229259984 0.2694198110427267 1.330179487848841 0.04844202154401991 0.11549408560152659 1.7054703978407601e-07 6.768155814319312 -0.35687502845781904 FCLFHSFFVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FCLFHSFFVTK 11 0 I3L1L3;Q9BQG0;Q9BQG0-2;I3L2H8 I3L1L3 MYBBP1A Myb-binding protein 1A 0 6530600.0 1350100.0 3605200.0 1575300.0 False True 1769994.174386998 3067318.212959535 1412303.0673446152 1.0 1.7329538465977377 0.7979139636624726 20.755313181272662 -6.697640834226842 1.8392494216245654 1.456196673497216 0.8008212847921415 0.4063015673332353 0.30952717911576116 0.40050837814756557 2.6323458254132333 0.13434140192996227 0.3465045980978038 2.0061304309492415e-07 6.697640834226842 -0.6553753887050745 FCLFHSFFVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FCLFHSFFVTK 11 0 I3L1L3;Q9BQG0;Q9BQG0-2;I3L2H8 I3L1L3 MYBBP1A Myb-binding protein 1A 0 54947000.0 15709000.0 16314000.0 22924000.0 False True 23831701.481733013 13402639.238136217 18393061.35205387 1.0 0.5623870057456591 0.7717896838441075 24.506378621682988 -10.083253740406725 4.973965006588732 1.0000091720220976 0.6670883447931789 0.7711680112273911 0.08548828535815137 23253862.099155154 47140378.052644104 1530.1368137048314 0.029264917028770723 8.255554705316179e-11 10.083253740406725 -0.3329208272289187 FCLFHSFFVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FCLFHSFFVTK 11 0 I3L1L3;Q9BQG0;Q9BQG0-2;I3L2H8 I3L1L3 MYBBP1A Myb-binding protein 1A 0 13137400.0 1350100.0 4557700.0 7229600.0 False True 1849268.4550806314 4356325.74370159 5522117.378285773 1.0 2.3557021868475263 2.9861091087745826 20.818523242795553 -9.35495116173353 0.23413002654568593 1.0466758732422939e-19 3.4459292111142457 0.9992360713056784 0.02290331525481281 0.7715103629570299 0.08949989248360532 0.8771056022439893 0.2958635478215591 4.416201066252712e-10 9.35495116173353 3.4459292111142457 FCLFHSFFVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FCLFHSFFVTK 11 0 I3L1L3;Q9BQG0;Q9BQG0-2;I3L2H8 I3L1L3 MYBBP1A Myb-binding protein 1A 0 6136170.0 1199800.0 556770.0 4379600.0 False True 997686.8601521864 553770.5694998077 5295354.111017538 1.0 0.5550544881540647 5.307631404717297 19.928227548321008 -6.8839805075064735 1.0573888085898653 0.7065859091246633 5.671192691080728 0.9767553846072117 0.3267597757796527 0.12416087257783263 0.2514949547858717 0.23713800771946864 0.5797034108611204 1.3062295144787672e-07 6.8839805075064735 4.964606781956065 up FCLFHSFFVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FCLFHSFFVTK 11 0 I3L1L3;Q9BQG0;Q9BQG0-2;I3L2H8 I3L1L3 MYBBP1A Myb-binding protein 1A 0 47365000.0 15709000.0 14844000.0 16812000.0 False True 20335610.17068385 14017918.351075307 13752388.50568729 1.0 0.6893286325523572 0.6762712498055731 24.277504943775437 FCLGLLSNVNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FCLGLLSNVNR 11 0 P84022;P84022-4;P84022-3;P84022-2;H0YNV1;H0YKE2;H0YAK7;H3BVD1;O15198-2;Q99717;Q15797;O15198;Q15796-2;Q15796;B7Z5N5 P84022;Q15796-2 SMAD3;SMAD5;SMAD9;SMAD1;SMAD2 Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 9;Mothers against decapentaplegic homolog 5;Mothers against decapentaplegic homolog 1;Mothers against decapentaplegic homolog 2 0 35845900.0 6698900.0 12637000.0 16510000.0 False True 8782322.77223989 10751608.858640186 14801703.575102905 1.0 1.2242329435471249 1.6853973554570005 23.06617112739972 -6.959495431647648 0.4424932709315466 0.9839328683220101 1.9437520150065715 0.9997510091769954 0.0045023560990427435 0.07988194601556202 0.021801573210488423 0.0060995265034338815 0.03819277819667714 1.0977528374970616e-07 6.959495431647648 0.9598191466845614 FCLGLLSNVNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FCLGLLSNVNR 11 0 P84022;P84022-4;P84022-3;P84022-2;H0YNV1;H0YKE2;H0YAK7;H3BVD1;O15198-2;Q99717;Q15797;O15198;Q15796-2;Q15796;B7Z5N5 P84022;Q15796-2 SMAD3;SMAD5;SMAD9;SMAD1;SMAD2 Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 9;Mothers against decapentaplegic homolog 5;Mothers against decapentaplegic homolog 1;Mothers against decapentaplegic homolog 2 0 17465400.0 7587500.0 5601300.0 4276600.0 False True 7346638.965687527 7837928.300393611 3156430.164750071 1.0 1.066872666126735 0.42964274949295533 22.8086529476344 -6.880978232953349 1.0743677039209725 1.042003409044333 0.3836340203972595 0.9744643013260098 0.04569247659544743 0.12676528880948587 0.26710115650832955 0.032733110530255176 0.07935482487710162 1.3152907535403618e-07 6.880978232953349 -0.6583693886470736 down FCLGLLSNVNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FCLGLLSNVNR 11 0 P84022;P84022-4;P84022-3;P84022-2;H0YNV1;H0YKE2;H0YAK7;H3BVD1;O15198-2;Q99717;Q15797;O15198;Q15796-2;Q15796;B7Z5N5 P84022;Q15796-2 SMAD3;SMAD5;SMAD9;SMAD1;SMAD2 Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 9;Mothers against decapentaplegic homolog 5;Mothers against decapentaplegic homolog 1;Mothers against decapentaplegic homolog 2 0 42172700.0 9936700.0 16098000.0 16138000.0 False True 15074700.37007679 13225186.125751924 12948317.226463316 1.0 0.8773100493595121 0.8589435881701281 23.84562599111963 -13.999999999999998 0.26741169928641073 1.933943162059005 0.8526925179463778 0.9995777854918685 0.0012866152726417842 14.757589966940623 0.1636766118860582 7.481219504157309 0.007727861810227848 1.0000000000000041e-14 13.999999999999998 -1.0812506441126273 FCLGLLSNVNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FCLGLLSNVNR 11 0 P84022;P84022-4;P84022-3;P84022-2;H0YNV1;H0YKE2;H0YAK7;H3BVD1;O15198-2;Q99717;Q15797;O15198;Q15796-2;Q15796;B7Z5N5 P84022;Q15796-2 SMAD3;SMAD5;SMAD9;SMAD1;SMAD2 Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 9;Mothers against decapentaplegic homolog 5;Mothers against decapentaplegic homolog 1;Mothers against decapentaplegic homolog 2 0 46645900.0 6698900.0 16097000.0 23850000.0 False True 9175664.360965602 15385781.314339347 18217121.206168503 1.0 1.6768029767732506 1.9853735369469663 23.12938118892261 -10.294280613696955 0.17388389565674683 2.5174665156356492e-20 2.3299490496800397 0.9995606676621165 0.008625847546492281 1.9629663663326744 0.08633621515606046 1.0970738990899616 0.22758019185848086 5.0783120803940304e-11 10.294280613696955 2.3299490496800397 FCLGLLSNVNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FCLGLLSNVNR 11 0 P84022;P84022-4;P84022-3;P84022-2;H0YNV1;H0YKE2;H0YAK7;H3BVD1;O15198-2;Q99717;Q15797;O15198;Q15796-2;Q15796;B7Z5N5 P84022;Q15796-2 SMAD3;SMAD5;SMAD9;SMAD1;SMAD2 Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 9;Mothers against decapentaplegic homolog 5;Mothers against decapentaplegic homolog 1;Mothers against decapentaplegic homolog 2 0 18213200.0 7587500.0 1823200.0 8802500.0 False True 6309342.433242816 1813378.0597231325 10643062.051838493 1.0 0.28741157718255433 1.6868734205583884 22.589058223068676 -6.768292516863635 1.5810737268519837 0.5903875049485804 1.694226417791354 0.7239605164784609 0.30018948607888774 0.2691976259186862 1.3278204413579733 0.14968181485739268 0.35685373616622995 1.7049336526984002e-07 6.768292516863635 1.1038389128427735 FCLGLLSNVNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FCLGLLSNVNR 11 0 P84022;P84022-4;P84022-3;P84022-2;H0YNV1;H0YKE2;H0YAK7;H3BVD1;O15198-2;Q99717;Q15797;O15198;Q15796-2;Q15796;B7Z5N5 P84022;Q15796-2 SMAD3;SMAD5;SMAD9;SMAD1;SMAD2 Mothers against decapentaplegic homolog 3;Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 9;Mothers against decapentaplegic homolog 5;Mothers against decapentaplegic homolog 1;Mothers against decapentaplegic homolog 2 0 40620700.0 9936700.0 17729000.0 12955000.0 False True 12863254.031640084 16742365.564956477 10597322.929525254 1.0 1.3015653367161093 0.8238446433117732 23.61675231321208 -6.736099081102609 1.7009162583963615 1.1802389298102975 0.8237942496092137 0.5872880090354353 0.12672252003922385 0.3249426663083345 1.8442981658207125 0.058975477204479786 0.14534832114239735 1.8361193983788132e-07 6.736099081102609 -0.3564446802010839 FCLGQLSNVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FCLGQLSNVHR 11 0 K7EIU8;Q13485;A0A087WUF3 K7EIU8 SMAD4 Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 4 0 10110100.0 2218000.0 3565100.0 4327000.0 False True 2907819.4791425564 3033200.976650954 3879283.547514852 1.0 1.0431187349860418 1.334086787484743 21.47150627715467 -6.933401643298233 0.7183143480799594 0.9960850056152325 1.399349209114942 0.9971657256928115 0.00789915876136333 0.09090934634061727 0.06930476120796698 0.007348131791616124 0.025852762617450533 1.1657310295002026e-07 6.933401643298233 0.4032642034997095 FCLGQLSNVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FCLGQLSNVHR 11 0 K7EIU8;Q13485;A0A087WUF3 K7EIU8 SMAD4 Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 4 0 11301100.0 2218000.0 2870500.0 6212600.0 False True 3038054.5391962407 2743671.818525883 4745311.8325133 1.0 0.9031015681672914 1.5619574208726146 21.534716338677562 -6.869522262996993 1.136702325138123 0.9453594327259633 1.6001809333463126 0.9641998041850496 0.05495679768048824 0.13730942831475518 0.3319018663871555 0.03753411528678407 0.088785296415457 1.3504475988348676e-07 6.869522262996993 0.6548215006203493 FCLICNYLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FCLICNYLSK 10 0 P40937;P40937-2;F5H5S0;E9PEP3 P40937 RFC5 Replication factor C subunit 5 0 22720300.0 8113400.0 6143100.0 8463800.0 False True 10636745.970277358 5226573.425616255 7588047.166502483 1.0 0.491369582409983 0.7133805007382932 23.342553528343835 -10.304980678289905 5.737591275196349 1.00004090127444 0.6023750415741361 0.8104977142856632 0.09063557787185458 4.742545252177428e-05 5.744663716939211e-06 0.0877665225029373 0.02925250697263009 4.954722338154778e-11 10.304980678289905 -0.3976658597003039 FCLICNYLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FCLICNYLSK 10 0 P40937;P40937-2;F5H5S0;E9PEP3 P40937 RFC5 Replication factor C subunit 5 0 22532300.0 8113400.0 6045300.0 8373600.0 False True 11113143.236390775 5778198.656866228 6395928.139705342 1.0 0.519942786118792 0.575528273473649 23.405763589866726 -10.123641296407998 5.20486246827823 1.0000118705666041 0.5477355298524814 0.9887977144430397 0.02269268019105857 3.2702205735373992e-06 5.505711336907488e-07 0.021972696039392135 0.00732403103783131 7.522439500420198e-11 10.123641296407998 -0.4522763407141227 FCLICNYVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FCLICNYVSR 10 0 P35249;C9JZI1;P35249-2;C9J8M3 P35249 RFC4 Replication factor C subunit 4 0 35377600.0 11087000.0 9694600.0 14596000.0 False True 14535164.36666072 8248203.469254819 13085745.934718454 1.0 0.5674654418200945 0.9002819372812327 23.79304405007341 -9.793195310386636 6.110069434535075 1.0000000112571208 0.7338736895503271 0.4601948184332969 0.13587176531138448 2.0818235434267062e-08 4.1709232461509575e-09 0.13155727498787906 0.04385242368905674 1.609921460430213e-10 9.793195310386636 -0.26612632170679373 FCLICNYVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FCLICNYVSR 10 0 P35249;C9JZI1;P35249-2;C9J8M3 P35249 RFC4 Replication factor C subunit 4 0 21512200.0 5656200.0 9711400.0 6144600.0 False True 8580868.923609292 7978324.794485479 4930117.116726142 1.0 0.9297805228715263 0.5745475383223115 23.032692315919476 -6.939545050681942 0.6637894019892175 1.0040203550516649 0.48002332205003473 0.9981035999312122 0.008109836527935467 0.08797503013831887 0.05556096342069324 0.007867314891102995 0.03063604541150261 1.1493570109520012e-07 6.939545050681942 -0.5239970330016301 FCLICNYVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FCLICNYVSR 10 0 P35249;C9JZI1;P35249-2;C9J8M3 P35249 RFC4 Replication factor C subunit 4 0 29379900.0 11087000.0 8512100.0 9780800.0 False True 15186163.51490923 8136007.27624949 7470776.481899066 1.0 0.5357513283892834 0.4919462690207784 23.8562541115963 -13.999999999999998 0.33392028381280686 6.1747418984666815 0.48453999885996296 0.9997229200603062 0.003826356393881897 19.159970304132628 0.18500301403181263 69.7719457269011 0.013835350588011636 1.0000000000000041e-14 13.999999999999998 -5.690201899606719 FCLICNYVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FCLICNYVSR 10 0 P35249;C9JZI1;P35249-2;C9J8M3 P35249 RFC4 Replication factor C subunit 4 0 23633100.0 5656200.0 12615000.0 5361900.0 False True 7322062.40037062 11912964.16052378 4386089.217739984 1.0 1.6269957163873368 0.5990237419334168 22.803818638011926 -6.741643584591787 1.6809539057941894 1.3723454152418846 0.5982285489169807 0.6122366953642575 0.2634269821545557 0.31482137492231627 1.7473258466793742 0.12395192345533151 0.30358748570918687 1.8128272275662594e-07 6.741643584591787 -0.7741168663249038 FCLQYGAALIYTSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FCLQYGAALIYTSVK 15 0 Q9Y6G9;E9PHI6;B4E2E0;O43237-2;O43237 Q9Y6G9 DYNC1LI1;DYNC1LI2 Cytoplasmic dynein 1 light intermediate chain 1;Cytoplasmic dynein 1 light intermediate chain 2 0 33298100.0 9757800.0 8754300.0 14786000.0 False True 14803295.990734885 7192026.767341909 11863540.619065981 1.0 0.4858395570718351 0.8014121062289883 23.81941509547659 -10.406179673008374 6.069675533948421 1.000088635868914 0.6436258316504151 0.6296853701561669 0.1288319537107315 0.00015456377407852863 1.5121426717469883e-05 0.12477183616397426 0.041580334265085624 3.924825269221972e-11 10.406179673008374 -0.35646280421849896 FCLQYGAALIYTSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FCLQYGAALIYTSVK 15 0 Q9Y6G9;E9PHI6;B4E2E0;O43237-2;O43237 Q9Y6G9 DYNC1LI1;DYNC1LI2 Cytoplasmic dynein 1 light intermediate chain 1;Cytoplasmic dynein 1 light intermediate chain 2 0 25475400.0 9757800.0 6278500.0 9439100.0 False True 12631664.454993876 5929095.955754938 7721280.6533448035 1.0 0.46938358574042827 0.6112639138615044 23.59054141756904 -10.399403091642625 8.952560709496888 1.0000019300643177 0.5403237498010189 0.9333147714968495 0.057922401405881264 2.2313550503597897e-06 1.4968478037612996e-07 0.056083359166322046 0.018694374668109935 3.9865471809914086e-11 10.399403091642625 -0.45967818026329876 FCLQYTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FCLQYTR 7 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 60776000.0 16399000.0 19509000.0 24868000.0 False True 21499247.808141876 16598333.245486407 22294897.910700094 1.0 0.7720425102128704 1.037008276273596 24.35778284949386 -6.679035557264857 1.9050032295321704 0.8556406971312343 1.0359976364282883 0.31970039244234827 0.09663502516818884 0.4407598440050216 3.09161600058582 0.040713116210675505 0.10752319007091694 2.0939410102852068e-07 6.679035557264857 0.1803569392970541 FCLQYTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FCLQYTR 7 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 25469500.0 10319000.0 8625900.0 6524600.0 False True 15654677.419950519 7086540.750535688 5235009.950166226 1.0 0.452678810328248 0.3344054821273202 23.900090444841904 -13.999999999999998 0.21530819695718292 4.236467374072204 0.2682247450357197 0.9994936467458888 0.006524219103382796 12.876230719212101 0.14703321230557895 17.67560101881926 0.06754199715573696 1.0000000000000041e-14 13.999999999999998 -3.968242629036484 FCLQYTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FCLQYTR 7 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 42650000.0 16399000.0 11293000.0 14958000.0 False True 22462153.466311567 10794037.919042941 11425228.469680008 1.0 0.4805433252529279 0.5086435050323831 24.42099291101675 -10.698812374020399 6.730327710913067 1.004748423726548 0.4945934151426676 0.9976869125429402 0.011471850356689784 0.0008206052293874672 3.6722712834592005e-05 0.011151476804102934 0.003702523781803596 2.0007260461837805e-11 10.698812374020399 -0.5101550085838804 FCLQYTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FCLQYTR 7 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 29276500.0 10319000.0 10522000.0 8435500.0 False True 13358148.917899702 9936441.450418632 6900325.5555392075 1.0 0.7438486807931871 0.5165630056940662 23.671216766934354 -6.972536266083631 0.18798091520025886 1.1581654787283702 0.09605008335873899 0.9999959999536682 0.00039491921516056886 0.07548799577390994 0.005982776622733108 0.008164086670486738 0.024916932879437664 1.0652799029628633e-07 6.972536266083631 -1.0621153953696312 FCNIMGSSNGVDQEHFSNVVK(ub)GEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FCNIMGSSNGVDQEHFSNVVKGEK 24 1 Q9NYL9;H0YNJ8 Q9NYL9 TMOD3 Tropomodulin-3 1 11709100.0 4254700.0 4892800.0 2561600.0 True False 5577952.902573413 4162813.3119850196 2296550.204602273 1.0 0.7462976802949497 0.411719181698854 22.411304322351096 -6.967308594932299 0.31593416540382074 1.048062517872974 0.09922690671204361 0.9999531284962406 0.0016493947715796003 0.07718607873192804 0.012141920513681452 0.005157815203264941 0.0295383383149321 1.0781803315929861e-07 6.967308594932299 -0.9488356111609305 down FCNIMGSSNGVDQEHFSNVVK(ub)GEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FCNIMGSSNGVDQEHFSNVVKGEK 24 1 Q9NYL9;H0YNJ8 Q9NYL9 TMOD3 Tropomodulin-3 1 40670800.0 7391800.0 15947000.0 17332000.0 True False 11213901.01296544 13101133.255520292 13906322.603114523 1.0 1.1682939987050756 1.2400967858585628 23.41878490426714 -13.999999999999964 0.11635385621999873 0.19521715137342607 1.3605380070931783 0.9997110015435257 0.0017105774767193426 11.979100880970966 0.10448940282300377 2.2407487514339794 0.10687409842483873 1.0000000000000819e-14 13.999999999999964 1.1653208557197523 FCNIMGSSNGVDQEHFSNVVK(ub)GEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FCNIMGSSNGVDQEHFSNVVKGEK 24 1 Q9NYL9;H0YNJ8 Q9NYL9 TMOD3 Tropomodulin-3 1 15025000.0 4254700.0 6986200.0 3784100.0 True False 5827777.568944203 6677526.583726008 2890373.5159858335 1.0 1.1458101316889744 0.4959649680846471 22.474514383873988 -6.8477887787062315 1.2457180049474974 1.0776861651973058 0.47107445407237025 0.9370257005878263 0.06986617471407294 0.15990561082286692 0.47862767340973916 0.04391058053780473 0.10147833289162765 1.4197478552733824e-07 6.8477887787062315 -0.6066117111249355 down FCNIMGSSNGVDQEHFSNVVK(ub)GEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FCNIMGSSNGVDQEHFSNVVKGEK 24 1 Q9NYL9;H0YNJ8 Q9NYL9 TMOD3 Tropomodulin-3 1 46332800.0 7391800.0 17072000.0 21869000.0 True False 9568830.814161366 16121928.1925059 17889066.394889068 1.0 1.6848378350097166 1.8695143369463896 23.18991122635959 -11.075280814281003 0.24819573907626805 4.831664501971231e-10 1.9598903963017904 0.999247576501878 0.01026008376658752 3.109381085097503 0.13325494029990026 1.8435360195403914 0.08538663032189499 8.408512724268847e-12 11.075280814281003 1.959890395818624 FCQLLWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FCQLLWR 7 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 17252000.0 5046100.0 6578400.0 5627500.0 False True 6615485.96650191 5596928.3624023665 5045220.282791732 1.0 0.8460343489114633 0.762637893623937 22.657415708550822 -13.999999982727694 0.07501069761301767 1.857778494327946 0.4888636960579152 0.9999064287999642 0.0009510522228323003 12.308681888675848 0.07557764523278213 1.7955185300959777 0.25028278197514764 1.0000000397709556e-14 13.999999982727694 -1.368914798270031 FCQLLWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FCQLLWR 7 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 17220800.0 5733400.0 8062700.0 3424700.0 False True 8697986.967685282 6623848.190837375 2747806.543900664 1.0 0.7615380679973726 0.31591292952142846 23.05225011651775 -6.9613503359287145 0.41596533207347663 1.0205742304099066 0.0401773683352358 0.9998170483968661 0.003834792874998041 0.07922223250464842 0.01937470601604558 0.005751410869319763 0.03713773401736892 1.0930742512638452e-07 6.9613503359287145 -0.9803968620746708 down FCQLLWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FCQLLWR 7 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 18127200.0 5046100.0 6135300.0 6945800.0 False True 6911779.535725038 5864222.159276029 5305345.093241306 1.0 0.848438832425936 0.7675801963618015 22.720625770073713 -13.999999203286947 0.0779828411728438 1.827618250697026 0.5168423006441452 0.9998948718324404 0.0009877489627045867 12.278647490028973 0.07798169774246505 1.769736694916761 0.22829829128916723 1.0000018345012816e-14 13.999999203286947 -1.3107759500528808 FCQLLWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FCQLLWR 7 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 9195500.0 4168900.0 1414800.0 3611800.0 False True 3466625.06358431 1407178.1915841878 4367010.680923641 1.0 0.40592165745471154 1.2597297373741303 21.725100378129607 -6.719558417147388 1.7606084208997168 0.638410819175048 1.258394322145573 0.510591968587082 0.25000316926750654 0.35616316738344456 2.1573066519391926 0.11275197048026164 0.2832283708078993 1.907399141611835e-07 6.719558417147388 0.6199835029705248 FCQLLWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FCQLLWR 7 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 16088500.0 5733400.0 5292700.0 5062400.0 False True 7421999.322210122 4998156.592342776 4141095.1446104753 1.0 0.6734245552119541 0.5579487365646028 22.8233764386102 -13.999999999999998 0.144852056592323 2.5679641034494174 0.4230631256548944 0.9995843178379388 0.003816688292326145 11.94211542533134 0.11957450670876589 5.280047964994379 0.12102222358671118 1.0000000000000041e-14 13.999999999999998 -2.144900977794523 FCQQYNK(ub)GIGGMDGTQQQIFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FCQQYNKGIGGMDGTQQQIFK 21 1 Q53R41 Q53R41 FASTKD1 FAST kinase domain-containing protein 1 1 21846100.0 3369200.0 4164900.0 14312000.0 True False 5111322.721513448 3421641.05448777 11483226.926827557 1.0 0.6694237951530932 2.2466252969108957 22.28526525321335 -6.851983625251427 1.225517273409654 0.8232552462176419 2.312118899150501 0.9431430233931876 0.1619357731691365 0.15528281898631147 0.4477990296951361 0.10334395847285667 0.23946154140889137 1.4061005390994774e-07 6.851983625251427 1.4888636529328592 up FCTGLTQIETLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FCTGLTQIETLFK 13 0 P12277 P12277 CKB Creatine kinase B-type 0 7022200.0 1120100.0 1208600.0 4693500.0 False True 1534231.2395643413 1155200.0556942632 3584991.96566674 1.0 0.7529504196657426 2.336669905564386 20.549084511767845 -6.867048684068082 1.149668081441753 0.8624989823534983 2.4243342692508696 0.9616438356366763 0.13624941611864036 0.13971204642518437 0.34699426603849615 0.09213384216613643 0.21706939563068833 1.3581611892577541e-07 6.867048684068082 1.5618352868973713 up FCVTWNTNSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FCVTWNTNSR 10 0 Q12788;J3KNP2 Q12788 TBL3 Transducin beta-like protein 3 0 24641200.0 6648100.0 7154100.0 10839000.0 False True 8715723.480291974 6086736.16646339 9717484.255029688 1.0 0.6983626982001827 1.1149371910436234 23.05518899478903 -6.712543617482372 1.7869178147467817 0.8150352007507824 1.1140002369764128 0.4768419770413088 0.12705932114410382 0.3699739163557167 2.3045531566766204 0.056561695179774954 0.14320993050002806 1.938457941097502e-07 6.712543617482372 0.2989650362256304 FCVTWNTNSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FCVTWNTNSR 10 0 Q12788;J3KNP2 Q12788 TBL3 Transducin beta-like protein 3 0 19429400.0 5179300.0 5391200.0 8858900.0 False True 7857376.757549164 4429098.238362137 7107934.532006193 1.0 0.5636866316874489 0.9046192834239587 22.905616307946413 -9.833465443266531 6.288147737296287 1.0000000122825967 0.7341529575556143 0.44773026570907004 0.13918517223506263 2.3893403987935777e-08 4.47099372381614e-09 0.13476546955069207 0.04492182117540351 1.4673528392630477e-10 9.833465443266531 -0.26584705472698245 FCVTWNTNSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FCVTWNTNSR 10 0 Q12788;J3KNP2 Q12788 TBL3 Transducin beta-like protein 3 0 22523300.0 6648100.0 4936200.0 10939000.0 False True 9106082.228147203 4718102.362169474 8355433.495776821 1.0 0.5181264833723621 0.9175662251269704 23.118399056311922 -10.029683507126467 7.169945438441425 1.0000000311436386 0.7178463542496666 0.39950207260789106 0.16307059171464608 8.128258619934802e-08 1.082878154028475e-08 0.15789244031395588 0.052630807163917735 9.339346593991745e-11 10.029683507126467 -0.28215367689397197 FCVTWNTNSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FCVTWNTNSR 10 0 Q12788;J3KNP2 Q12788 TBL3 Transducin beta-like protein 3 0 21261300.0 5179300.0 8393400.0 7688600.0 False True 6704705.949266209 7926299.911608421 6289353.691698019 1.0 1.1821994837038168 0.9380506377593416 22.676742630038863 -6.706963044417141 1.8062923962439392 1.1123623326574623 0.9386813788859345 0.450491691439035 0.07681590560715376 0.3812423906128168 2.4228427267338546 0.033868896013025215 0.08635282972328087 1.9635273528951928e-07 6.706963044417141 -0.1736809537715278 FDAGELITQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDAGELITQR 10 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2 P35232 PHB Prohibitin 0 24045300.0 1799500.0 8461800.0 13784000.0 False True 2359161.9263827913 7199332.423838052 12357763.905464476 1.0 3.051648275316354 5.238200806509345 21.16984301391769 -6.970316654621456 0.25050899917824876 0.31042114774743673 8.043510493276276 0.9999847478127016 0.006758419345937181 0.07620011779459464 0.008661800985916087 0.04860051939739617 0.2093864561020656 1.0707383193220807e-07 6.970316654621456 7.73308934552884 FDAGELITQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDAGELITQR 10 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2 P35232 PHB Prohibitin 0 16101100.0 6205500.0 0.0 9895600.0 False True 6008509.799218967 0.0 7303645.498363369 1.0 0.0 1.2155502349871767 22.518575794560284 -6.688095677949435 1.8728729468385468 0.3719697185703822 1.2112976125403854 0.36171251836899154 0.42309088852866933 0.42074676777075837 2.859792664501268 0.18080927412410414 0.47202705263905553 2.0507103439916074e-07 6.688095677949435 0.8393278939700032 FDAGELITQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FDAGELITQR 10 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2 P35232 PHB Prohibitin 0 20044400.0 1799500.0 8207900.0 10037000.0 False True 2464823.7796589886 7845247.838104369 7666467.318503689 1.0 3.1828838649024105 3.1103510854493437 21.23305307544058 -10.13132354279164 4.438644735824728 0.9997059013845844 3.1466174751849882 0.9991444431175767 0.029611383666376334 5169001.758622958 9.459697607084745 15808.129766446871 0.010136764176819912 7.390544855540631e-11 10.13132354279164 2.146911573800404 FDAGELITQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FDAGELITQR 10 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2 P35232 PHB Prohibitin 0 9357400.0 6205500.0 1681100.0 1470800.0 False True 5160148.200262044 1672043.5806277776 1778337.4797891611 1.0 0.32403014714632955 0.3446291483835393 22.29898106999456 -10.650996434929827 10.295249009041283 1.0001698950036901 0.3343296478054331 0.9992823320115884 0.008409507040353884 3.280151137018477e-05 1.111947161405742e-06 0.008144416062912564 0.002714156726425386 2.233590558026411e-11 10.650996434929827 -0.665840247198257 FDAMPFTLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDAMPFTLR 9 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 12821900.0 2231500.0 4408800.0 6181600.0 False True 2925518.1098767393 3751024.2253678017 5541987.330094244 1.0 1.282174331002806 1.8943609719536976 21.480260718244814 -6.958423172114291 0.4571200246085341 0.9816333241660495 2.2194613365510527 0.9997071548172626 0.0063884313596806516 0.08026935968269655 0.02324998423902122 0.008274269221574876 0.05058945476103301 1.1004665036219992e-07 6.958423172114291 1.2378280123850032 FDAMPFTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDAMPFTLR 9 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 8542200.0 3251800.0 1515500.0 3774900.0 False True 3148573.3889453267 2120647.0532280966 2786140.4454274466 1.0 0.6735263216902329 0.8848897901537294 21.586266864318254 -10.522373471092195 6.366959189475109 1.0002008882826539 0.7792080559219812 0.5926582044140665 0.08628877466673508 0.0002462827819781822 1.8475249442615528e-05 0.08362403837576028 0.02784958227074245 3.003492341605941e-11 10.522373471092195 -0.2209928323606727 FDAMPFTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FDAMPFTLR 9 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 13389000.0 2231500.0 4743200.0 6414300.0 False True 3056545.85402002 4533629.740335122 4899374.446655194 1.0 1.4832526508223054 1.6029121369834696 21.543470779767706 -11.751277244401534 0.2379056084488379 8.430131497769422e-13 1.6635267335841104 0.9993419771307279 0.0066856810778953245 4.562939840817689 0.1381267064297844 2.3500558364845396 0.05896141791780071 1.7730572373307072e-12 11.751277244401534 1.6635267335832673 FDASFFGVHPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDASFFGVHPK 11 0 P49327;A0A0U1RQF0;A0A0U1RRG3 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 66237100.0 17105800.0 15154300.0 33977000.0 False True 22425869.45280285 12893337.510998731 30461385.970397964 1.0 0.5749314441580005 1.3583146033426503 24.418660583845746 -6.75936126132367 1.6150168958626512 0.7528991221950831 1.3610725095878307 0.6883030976448998 0.17876800496934428 0.2839903719887887 1.4597797162746216 0.08734482774583269 0.21002405474597896 1.740358580032126e-07 6.75936126132367 0.6081733873927475 FDASFFGVHPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDASFFGVHPK 11 0 P49327;A0A0U1RQF0;A0A0U1RRG3 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 24976200.0 6812100.0 2681500.0 15482600.0 False True 6595853.614255016 3752236.933837769 11427242.591956088 1.0 0.5688781397040714 1.7324888119498942 22.653127949856398 -6.80639012673536 1.4296219893653426 0.7640174278287397 1.751212309300197 0.8501915458254701 0.18590966504280684 0.21177048067620327 0.8536939250875074 0.10227099818553922 0.23698756653911332 1.561744097602051e-07 6.80639012673536 0.9871948814714573 FDASFFGVHPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FDASFFGVHPK 11 0 P49327;A0A0U1RQF0;A0A0U1RRG3 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 45120800.0 17105800.0 11982700.0 16032300.0 False True 23430276.526863407 11453264.692510054 12245800.935583029 1.0 0.48882328295949024 0.5226485876742815 24.481870645368637 -10.032476995111681 5.231758931361124 1.000004286588426 0.5057359353155425 0.9964997111925538 0.013809122828925862 4082791.2025798745 7829204.993657456 136.05766868346407 0.0047272295092041705 9.27946642820705e-11 10.032476995111681 -0.4942683512728835 FDASFFGVHPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FDASFFGVHPK 11 0 P49327;A0A0U1RQF0;A0A0U1RRG3 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 21123700.0 6812100.0 7101700.0 7209900.0 False True 5664562.977198461 7063441.732522919 8717456.755188912 1.0 1.2469526353498686 1.5389460387816765 22.433533225290674 -6.96890953943423 0.28302530287662103 0.9379710454697362 1.8568622301334141 0.9999725813449318 0.001153432657148465 0.07665817822487296 0.01029101926764901 0.005301192467597584 0.026700499191455243 1.0742131402789622e-07 6.96890953943423 0.9188911846636779 FDASFFGVHPK(ub)QAHTMDPQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDASFFGVHPKQAHTMDPQLR 21 1 P49327;A0A0U1RQF0;A0A0U1RRG3 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 11968000.0 2637400.0 1987200.0 7343400.0 True False 2553677.1806397717 2780699.3231110983 5419943.242722168 1.0 1.088900094417749 2.122407359791777 21.284144729710878 -6.923853958766631 0.7956012802135043 0.9802073116164814 2.3048093241616274 0.9951868186657775 0.03534404758358294 0.09595610000201013 0.094243362385046 0.03109191202628281 0.09686531328002647 1.1916426571568269e-07 6.923853958766631 1.3246020125451459 up FDASFFGVHPK(ub)QAHTMDPQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FDASFFGVHPKQAHTMDPQLR 21 1 P49327;A0A0U1RQF0;A0A0U1RRG3 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 92820600.0 10873900.0 6372700.0 75574000.0 True False 16496501.288574463 5235441.894867645 60636765.77473904 1.0 0.31736680422616226 3.6757349157870394 23.975656742691694 -6.853769866400618 1.2166849506400506 0.6341719058270834 3.8201354020590332 0.945622529362353 0.33796146888447 0.15335887948243615 0.43496138472583223 0.2171213254996426 0.5038195331639874 1.4003291635016216e-07 6.853769866400618 3.18596349623195 up FDASFFGVHPK(ub)QAHTMDPQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FDASFFGVHPKQAHTMDPQLR 21 1 P49327;A0A0U1RQF0;A0A0U1RRG3 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 4765700.0 1647900.0 1313500.0 1804300.0 True False 2257173.1628230275 1255465.226836352 1378161.5007249382 1.0 0.5562113033747718 0.610569682213164 21.106085670868136 -10.100961355169263 4.973754269564956 1.0000140647451687 0.5833904927929875 0.9873925923159824 0.022191715239200167 3.4611802261198243e-06 6.255991579415157e-07 0.021487760695459213 0.007162345294569903 7.925718527728161e-11 10.100961355169263 -0.41662357195218125 FDASFFGVHPK(ub)QAHTMDPQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FDASFFGVHPKQAHTMDPQLR 21 1 P49327;A0A0U1RQF0;A0A0U1RRG3 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 14835000.0 2637400.0 4271300.0 7926300.0 True False 2193114.956630588 4248289.6591133345 9583652.68292958 1.0 1.9371030443567048 4.369881594193088 21.064550005145154 -6.9546485801546725 0.5052401077323873 0.9534150758841017 5.459437201193109 0.9995173955649951 0.031199290281124163 0.08167107801397776 0.028639798004388956 0.03623797190425345 0.20072682852319196 1.1100726940133375e-07 6.9546485801546725 4.506022125309007 FDASFFGVHPK(ub)QAHTMDPQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FDASFFGVHPKQAHTMDPQLR 21 1 P49327;A0A0U1RQF0;A0A0U1RRG3 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 117584000.0 14541000.0 22449000.0 80594000.0 True False 18823611.145961776 21199693.41574303 65926718.96427313 1.0 1.1262288224802708 3.502341737356616 24.16604008731589 -6.917889785677833 0.8402273514298266 0.9434798280271093 3.8675130801041204 0.9935744136166108 0.09226523812835795 0.09942944247565624 0.11216498458188262 0.07862011209402989 0.2309571257509912 1.2081203904082312e-07 6.917889785677833 2.9240332520770114 up FDDAVVQSDMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDDAVVQSDMK 11 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 11775750.0 711650.0 5812900.0 5251200.0 False True 932980.0416284035 4945637.97850673 4707856.197067254 1.0 5.300904368623705 5.046041701867773 19.831486693614913 -10.166443485507289 4.312546692697362 0.9989402393852755 5.173473035474178 0.9972108908753733 0.10404724878276456 18369661.66064463 31169218.01734736 255531.1795266305 0.03807739630236445 6.816422706746965e-11 10.166443485507289 4.1745327960889025 FDDAVVQSDMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDDAVVQSDMK 11 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 12577500.0 2374600.0 1474700.0 8728200.0 False True 2299219.6227903245 2063555.4004589065 6442022.579612669 1.0 0.8975025178127974 2.8018300277877124 21.13271284902846 -6.894186945595495 0.99731091833262 0.9077099279486583 2.979696256334217 0.9834448099457086 0.11252587414759246 0.1158107540125743 0.20254181356229117 0.085464059195337 0.21653325327959497 1.2758894735755033e-07 6.894186945595495 2.0719863283855586 up FDDAVVQSDMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FDDAVVQSDMK 11 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 9164450.0 711650.0 4277300.0 4175500.0 False True 974766.2366181259 4088314.7428603913 3189332.8971218676 1.0 4.194148903889485 3.2718951245039065 19.894696755137804 -9.799176905425064 11.235199513136832 0.9999999999047352 3.733022014196696 0.921316321382911 0.3765085288079992 0.0 0.0 0.3645528181607393 0.12151760514820302 1.587899802063937e-10 9.799176905425064 2.7330220142919606 FDDCSSK(ub)ETAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDDCSSKETAIK 12 1 Q8IX18-3;Q8IX18-2;Q8IX18;J3KSW6;J3KTK0 Q8IX18-3 DHX40 Probable ATP-dependent RNA helicase DHX40 1 3772510.0 1341200.0 1447300.0 984010.0 True False 1758326.1881992754 1231368.4815312147 882194.0844904307 1.0 0.7003071954426585 0.501723793009019 20.74577129989938 -8.341515069466091 0.1218485142625619 1.4741026467224505 6.24755348346487e-12 0.9999632729602449 0.0012412033230724492 0.09764667105293033 0.026738198208366357 0.15261253388722437 0.14782039346798842 4.554963807465152e-09 8.341515069466091 -1.474102646716203 FDDGAGGDNEVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDDGAGGDNEVQR 13 0 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 0 5017760.0 1241100.0 587860.0 3188800.0 False True 1201701.959843794 822595.5636494008 2353557.618050557 1.0 0.6845254406977317 1.9585202460321276 20.196647699672923 -6.841177771895237 1.2769381872292598 0.8321955654475454 2.0014032923374097 0.926458460121141 0.1469122189670835 0.16742605449194725 0.5297992900932617 0.09019730352220261 0.20786441549071688 1.4415251641590863e-07 6.841177771895237 1.1692077268898644 FDDPGLMLMGFKPLVLLKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FDDPGLMLMGFKPLVLLKK 19 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 43134300.0 6919600.0 4047700.0 32167000.0 True False 8957558.605707798 3822441.9367857343 26312936.061292097 1.0 0.4267280969113678 2.937512018567802 23.0946741467652 -6.846676162574921 1.2511151565017944 0.6947580288655023 3.03157729956373 0.9353150259803567 0.27322332186419346 0.16115165451421803 0.48710340454661566 0.17102687300369734 0.39499524288142807 1.4233897609122598e-07 6.846676162574921 2.3368192706982276 up FDEILEASDGIMVAR ddPTM_RPMI8226_Bortezomib_2h_R1 2 FDEILEASDGIMVAR 15 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 22799300.0 9045100.0 1448100.0 12306100.0 False True 8757968.251537425 2026333.8817417386 9082763.234913433 1.0 0.23137031598464908 1.037085654348997 23.062164789218354 -9.887425220824468 13.868282874728763 0.9999995202153673 0.6342279851668229 0.21555531963564256 0.32893190948787465 0.0 0.0 0.31848695187063325 0.10616231729021107 1.2959098150767846e-10 9.887425220824468 -0.3657715350485444 FDEISFVNFAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDEISFVNFAR 11 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 14385500.0 4087200.0 5694700.0 4603600.0 False True 5358358.780501099 4845072.957766743 4127263.632849405 1.0 0.9042083884710768 0.7702477198556373 22.353359752505295 -6.966396617586534 0.3332272442886424 1.015718576921087 0.6543309929090247 0.9999390913034412 0.0007353584168642138 0.07749031173288198 0.013206885038992387 0.0019328558244311226 0.01165443848343992 1.080446787176582e-07 6.966396617586534 -0.3613875840120623 FDEISFVNFAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDEISFVNFAR 11 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 19621600.0 5973800.0 3211800.0 10436000.0 False True 5784164.988892804 4494288.489315731 7702498.526710865 1.0 0.7769986675597961 1.331652631192539 22.463677273975346 -6.797587184671708 1.46573399862147 0.8765771009979471 1.3388603464265718 0.8249909468529389 0.09533155308178085 0.224236318349179 0.9513110309832239 0.05117250818339095 0.11918808921547708 1.5937229085223042e-07 6.797587184671708 0.46228324542862476 FDEISFVNFAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FDEISFVNFAR 11 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 18159100.0 4087200.0 6966500.0 7105400.0 False True 5598348.292426896 6658696.994865207 5427250.860306474 1.0 1.1894038468225863 0.9694378728897821 22.416569814028186 -6.678874062538128 1.906091249418362 1.1199598672859188 0.9702862001774047 0.31891214957893865 0.08029379563777972 0.44101511235333263 3.096943389976672 0.03381519061138844 0.08930749394104298 2.0947197982424878e-07 6.678874062538128 -0.14967366710851404 FDEISFVNFAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FDEISFVNFAR 11 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 11578300.0 5973800.0 2926800.0 2677700.0 False True 4967479.384211655 2911032.7474756883 3237594.689714053 1.0 0.5860180832814212 0.6517580525858314 22.244082549409622 -10.62260757630209 6.534768168931454 1.0013028083954185 0.6188880679336421 0.9781711904000006 0.02683823008367228 0.000510953501397108 2.9508337213497583e-05 0.026064803244452157 0.008662001512978806 2.384473079765874e-11 10.62260757630209 -0.38241474046177637 FDELK(ub)MTNPAIQNDFSYYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDELKMTNPAIQNDFSYYR 19 1 Q9NUQ9;A0A1W2PRQ0;A0A087X178 Q9NUQ9 FAM49B Protein FAM49B 1 18342100.0 2130600.0 2347500.0 13864000.0 True False 2062965.2692314761 3284868.9920507753 10232602.488915233 1.0 1.5923045535684173 4.96014287856975 20.976288102458756 -6.936982854676251 0.6870565368649234 0.9595068288979254 5.793032030174592 0.9977414465251814 0.08288540555852486 0.08917037751833862 0.0610817384424052 0.07894532100535659 0.29392258488737083 1.156157884747517e-07 6.936982854676251 4.833525201276666 FDELK(ub)MTNPAIQNDFSYYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FDELKMTNPAIQNDFSYYR 19 1 Q9NUQ9;A0A1W2PRQ0;A0A087X178 Q9NUQ9 FAM49B Protein FAM49B 1 46731800.0 6785800.0 18649000.0 21297000.0 True False 10294554.708431076 15320940.244697949 17087638.615193292 1.0 1.4882567219882121 1.6598715630894447 23.295378091672525 -11.5017729931945 0.1869860368300959 2.864383096475019e-09 1.8071157609364585 0.9994372585983363 0.006631261400567662 4.123273577044199 0.11294000205695351 1.7926414126645256 0.1189856785422073 3.149394080057017e-12 11.5017729931945 1.8071157580720754 FDELK(ub)MTNPAIQNDFSYYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FDELKMTNPAIQNDFSYYR 19 1 Q9NUQ9;A0A1W2PRQ0;A0A087X178 Q9NUQ9 FAM49B Protein FAM49B 1 26794100.0 6785800.0 9913300.0 10095000.0 True False 8784351.868115498 9361616.140508942 8257813.583447131 1.0 1.0657150670943336 0.940059518041446 23.066504413764974 -6.764594488243887 1.595052387550137 1.0379530996223043 0.93949159758227 0.709442167624742 0.027661463005449936 0.27528909327962553 1.3813146547629551 0.013676226260472952 0.03272041128221496 1.7195131908304432e-07 6.764594488243887 -0.09846150204003434 FDFLCQYHKPASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDFLCQYHKPASK 13 1 J3KQ32;Q9NTK5;Q9NTK5-3;C9JTK6 J3KQ32 OLA1 Obg-like ATPase 1 0 74083100.0 6535700.0 8099400.0 59448000.0 False True 8568365.991808822 6891001.091213921 53296891.22548255 1.0 0.804237482129215 6.2201931239203905 23.030588674446253 -6.8985141615009 0.970623880733371 0.7655525463799429 6.77182117227725 0.9858121678685019 0.29876295102263717 0.1125068932123094 0.18365691915158439 0.2314879526615479 0.5979186802943387 1.263239911331838e-07 6.8985141615009 6.006268625897308 up FDFLCQYHKPASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FDFLCQYHKPASK 13 1 J3KQ32;Q9NTK5;Q9NTK5-3;C9JTK6 J3KQ32 OLA1 Obg-like ATPase 1 0 95123700.0 6535700.0 10253000.0 78335000.0 False True 8952124.910651412 9799988.557863042 59833886.359966815 1.0 1.0947108821284235 6.683763570900949 23.093798735969145 -6.910579169477132 0.8917875611682107 0.830105871593684 7.415059737092258 0.9911381649207714 0.250152004274272 0.10403610614644751 0.1367012914099532 0.2053911153134041 0.5692690217786448 1.2286291938699985e-07 6.910579169477132 6.584953865498574 up FDGAEGSWFQK(ub)ISSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDGAEGSWFQKISSR 15 1 M0QZR4;Q92888;Q92888-3;M0QYS3;M0QYC1;Q92888-2;Q92888-4 M0QZR4 ARHGEF1 Rho guanine nucleotide exchange factor 1 1 7463500.0 1743300.0 2625400.0 3094800.0 True False 2285483.182141217 2233700.553729049 2774579.783417834 1.0 0.9773428092506662 1.2140014002721269 21.124067772151164 -6.88341684284779 1.0605273427420325 0.9852059491121612 1.2319143825664147 0.9763399589567774 0.016400642662706834 0.12464787617999747 0.25434449941296433 0.011873436321329327 0.028980052521726845 1.3079259519230246e-07 6.88341684284779 0.24670843345425353 FDGAEGSWFQK(ub)ISSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDGAEGSWFQKISSR 15 1 M0QZR4;Q92888;Q92888-3;M0QYS3;M0QYC1;Q92888-2;Q92888-4 M0QZR4 ARHGEF1 Rho guanine nucleotide exchange factor 1 1 6470700.0 1844600.0 1914500.0 2711600.0 True False 1786044.1826829906 2678969.833985608 2001350.6137436938 1.0 1.4999460035536563 1.1205493308330539 20.76833633922856 -10.668676628225965 11.54141023561943 0.9999534660873441 1.310247667193355 0.47134625609441805 0.15488804304586365 0.00018548681626037917 5.324768186189028e-06 0.1499919670505148 0.049989900936940626 2.1444867724058462e-11 10.668676628225965 0.3102942011060108 FDGAEGSWFQK(ub)ISSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FDGAEGSWFQKISSR 15 1 M0QZR4;Q92888;Q92888-3;M0QYS3;M0QYC1;Q92888-2;Q92888-4 M0QZR4 ARHGEF1 Rho guanine nucleotide exchange factor 1 1 17342000.0 3630700.0 6219100.0 7492200.0 True False 4700012.721796538 5873001.6179717295 6128696.476463843 1.0 1.2495714300379228 1.303974444163037 22.164233231145925 -13.117337205140233 0.2260770052459639 1.0185571944811243e-08 1.3323886163932153 0.9994557909037024 0.00308746775440074 8.838075166124204 0.14578602071559427 3.977995809802228 0.028944484403324464 7.632429384113552e-14 13.117337205140233 1.3323886062076433 FDGALNVDLTEFQTNLVPYPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FDGALNVDLTEFQTNLVPYPR 21 0 F8VVB9;P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 795520000.0 237520000.0 326890000.0 231110000.0 False True 360335205.0379547 268553925.4967724 185431007.2008886 1.0 0.7452891689239335 0.5146069676465747 28.424764370209903 -6.972304297366881 0.19546148362521873 1.1456120676922934 0.10794588109153883 0.9999952190192798 0.000433426229162623 0.07556182798735733 0.00627635821585824 0.007776895531305386 0.024778442600364697 1.0658490504623166e-07 6.972304297366881 -1.0376661866007546 FDGALNVDLTEFQTNLVPYPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FDGALNVDLTEFQTNLVPYPR 21 0 F8VVB9;P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 455134000.0 237520000.0 50254000.0 167360000.0 False True 307474322.219163 47457320.72318364 136902197.25861427 1.0 0.15434563894853237 0.4452475779783408 28.195890692302353 -10.394204930737716 5.883188859372085 1.0001910809568941 0.29979660855815576 0.8853857529012952 0.11876021930154457 0.0002977272773084669 3.065704317431157e-05 0.11501968917342165 0.03832969596223488 4.0345496956076096e-11 10.394204930737716 -0.7003944723987383 FDGILGMAYPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDGILGMAYPR 11 0 A0A1B0GW44;A0A1B0GVD5;A0A1B0GWE8;A0A1B0GU92;A0A1B0GU03;P07339;C9JH19;A0A1B0GVP3;A0A1B0GV23;F8WD96;H7C469;F8W787 A0A1B0GW44 CTSD Cathepsin D;Cathepsin D light chain;Cathepsin D heavy chain 0 5117300.0 2655700.0 2461600.0 0.0 False True 3481648.4178353813 2094338.875241648 0.0 1.0 0.6015365780510789 0.0 21.73133909412401 -7.647955496724957 0.6626086501340869 0.9982177257993978 3.4550300210574275e-21 0.9872642797097961 0.046387477304576596 0.12101984657838906 0.14873122090609575 0.042546507065969484 0.07756519606169189 2.2492850840672855e-08 7.647955496724957 -0.9982177257993978 down FDGILGMAYPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDGILGMAYPR 11 0 A0A1B0GW44;A0A1B0GVD5;A0A1B0GWE8;A0A1B0GU92;A0A1B0GU03;P07339;C9JH19;A0A1B0GVP3;A0A1B0GV23;F8WD96;H7C469;F8W787 A0A1B0GW44 CTSD Cathepsin D;Cathepsin D light chain;Cathepsin D heavy chain 0 7289200.0 2704700.0 1243600.0 3340900.0 False True 2618840.7789779278 1740175.9652883285 2465818.0651483634 1.0 0.66448330087768 0.9415685309859557 21.320496918298016 -9.995825432552856 6.575998021937701 1.0000000490861671 0.8030259159318162 0.4025565879119153 0.11311957150449567 8.147523202883929e-08 1.2409436291372652e-08 0.1095275818871907 0.036509184713918334 1.009658643277881e-10 9.995825432552856 -0.19697413315435097 FDGILGMAYPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FDGILGMAYPR 11 0 A0A1B0GW44;A0A1B0GVD5;A0A1B0GWE8;A0A1B0GU92;A0A1B0GU03;P07339;C9JH19;A0A1B0GVP3;A0A1B0GV23;F8WD96;H7C469;F8W787 A0A1B0GW44 CTSD Cathepsin D;Cathepsin D light chain;Cathepsin D heavy chain 0 8665900.0 2655700.0 2863100.0 3147100.0 False True 3637584.057593979 2736598.774994408 2403819.7965590297 1.0 0.7523121752420717 0.6608286594891768 21.7945491556469 -13.999999999999998 0.13839317988979896 2.1815907744101817 0.5453910183654762 0.9996094157973544 0.0028316142655711693 11.932739355145127 0.11643508627212658 3.811212889629193 0.10309267075437308 1.0000000000000041e-14 13.999999999999998 -1.6361997560447055 FDILCVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDILCVVR 8 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 49766000.0 19621000.0 16152000.0 13993000.0 False True 25723321.01003426 13742184.56000289 12545138.590334037 1.0 0.5342305744519644 0.48769513802049036 24.616573578083056 -13.999999999999918 0.32560875847507503 5.938218301951227 0.47902391638122 0.9997056552080401 0.003968560530265834 18.459201179019335 0.18224422869676674 62.28230578884782 0.015161527403087103 1.0000000000001882e-14 13.999999999999918 -5.459194385570006 FDILCVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FDILCVVR 8 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 58347000.0 19621000.0 18461000.0 20265000.0 False True 26875413.937587615 17645331.977636743 15478824.37077586 1.0 0.6565603796322632 0.5759473847257612 24.679783639605947 -13.999999999999181 0.20361111571570348 2.9359316071439 0.5254177734131976 0.9994874394720716 0.004162750349291266 12.604650269007823 0.14306167158275027 9.733102625611314 0.04998175234657859 1.0000000000018855e-14 13.999999999999181 -2.4105138337307026 FDKDHDVMLFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDKDHDVMLFLK 12 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 18578000.0 4778100.0 7019400.0 6780500.0 False True 6264135.371186217 5972132.881406893 6078918.9031487005 1.0 0.9533850288225766 0.970432237322093 22.57868395967164 -10.13097032013103 4.709005584120872 1.0000030800719284 0.9619086330719163 0.8694022349088949 0.0069594937285442455 2.250634420581949e-07 4.1533820639740555e-08 0.006739045646126607 0.0022461669421872314 7.396558217233883e-11 10.13097032013103 -0.03809444700001208 FDKDHDVMLFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FDKDHDVMLFLK 12 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 15743600.0 4778100.0 3741600.0 7223900.0 False True 6544692.693297357 3576283.7401833953 5517763.600890583 1.0 0.5464402849420248 0.8430897919074968 22.64189402119453 -10.420676120748444 6.98929581752471 1.0000272626651807 0.6947650384247613 0.5853422166926361 0.12110665408560176 5.145283196262649e-05 4.264764015492161e-06 0.11727146328902276 0.03908700453236983 3.795979682467089e-11 10.420676120748444 -0.3052622242404194 FDKDHDVMLFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FDKDHDVMLFLK 12 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 8165700.0 3489800.0 1853900.0 2822000.0 False True 2901923.3243533145 1843912.6727296612 3412067.1525462386 1.0 0.6354105421240143 1.1757950749117771 21.46857796983268 -6.724973393673847 1.74162234204431 0.7793727633830079 1.17518652647795 0.5358004612847131 0.1533344047307412 0.3457351239073473 2.052071131480216 0.06983890961120229 0.17429120628247055 1.8837644916404602e-07 6.724973393673847 0.3958137630949421 FDLLWLIQDRPDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FDLLWLIQDRPDR 13 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 41676000.0 9945000.0 14500000.0 17231000.0 False True 15087292.076888064 11912361.710982913 13825285.297384396 1.0 0.7895626100611676 0.9163529960796005 23.84683055305699 -10.273596978225086 5.1587472646320425 1.0000263094320792 0.8529578031084376 0.6419989665657715 0.05176195833939062 1.56656133157424e-05 2.205893245064287e-06 0.05012726344992462 0.016706100217945722 5.3260228062631345e-11 10.273596978225086 -0.14706850632364155 FDLLWLIQDRPDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FDLLWLIQDRPDR 13 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 30594800.0 9945000.0 12765000.0 7884800.0 False True 12873998.54525754 12054616.528663192 6449847.304880028 1.0 0.9363537277316076 0.5009979830435813 23.61795687514944 -6.933130233921403 0.720645135739408 1.005913483594132 0.40405693283596 0.9971182632599321 0.011904355877763255 0.09104520130255071 0.06995730105957826 0.011054811054208734 0.03873667275023403 1.1664597728507277e-07 6.933130233921403 -0.6018565507581719 FDLMYAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 FDLMYAK 7 0 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q6PEY2;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 59159500.0 6307500.0 26771800.0 26080200.0 False True 8269193.581916891 22777551.795659076 23381671.0829436 1.0 2.754507022966439 2.82756363741136 22.979315212856623 -10.571712779076655 0.6061658737515473 1.725901992399245e-20 2.8186456704345404 0.9998496794740676 0.010358044586269122 2.0196185298416247 0.2967924428417036 3.117428792801533 0.012589875657243248 2.6809407804850493e-11 10.571712779076655 2.8186456704345404 FDLMYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDLMYAK 7 0 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q6PEY2;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 36171000.0 10729000.0 4064000.0 21378000.0 False True 10388413.767757677 5686776.393480023 15778460.473747134 1.0 0.5474152763466126 1.5188517541261635 23.308472046644685 -6.779992657823838 1.5356789257665278 0.7437378078265885 1.5265776998628235 0.767454250332647 0.19139454040040035 0.2505756240535661 1.1671763539057862 0.0981587361722061 0.23163613849865677 1.659614964626722e-07 6.779992657823838 0.782839892036235 FDLMYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FDLMYAK 7 0 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q6PEY2;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 109731700.0 4600900.0 100860000.0 4270800.0 False True 6979901.670845079 82860744.97722314 3426674.508041859 1.0 11.871334136887766 0.4909344958762121 22.734775281979246 -6.656515961796463 1.9851243421961504 8.017492342691117 0.538413773223746 0.221044377284625 4.632598339849053 0.49269490792470394 3.7285691779297334 1.8877851553988696 5.134150573055736 2.2053830795886508e-07 6.656515961796463 -7.479078569467371 FDLMYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FDLMYAK 7 0 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q6PEY2;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 69871400.0 6307500.0 30641300.0 32922600.0 False True 8639553.203778304 29287466.048770964 25146959.94223074 1.0 3.389928316659105 2.9106782896172585 23.042525274379514 -10.100420353779157 5.009476314128848 0.999932999765861 3.1503033031457903 0.9640829615613856 0.19565300427098342 0.00014640974153245655 2.629038800601755e-05 0.1894459899956643 0.06314673559430375 7.935597761069899e-11 10.100420353779157 2.1503703033799293 FDLMYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FDLMYAK 7 0 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q6PEY2;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 17119200.0 10729000.0 3830700.0 2559500.0 False True 8921638.875289895 3810063.2587655853 3094679.616209103 1.0 0.4270586729662697 0.3468734455034245 23.08887732207896 -13.999999999997641 0.2770318295530387 5.59395329073732 0.32201968894940286 0.9995986293231932 0.0058266575309599885 15.239998236441469 0.16669230235038235 39.5964646259944 0.03217277494388301 1.0000000000054318e-14 13.999999999997641 -5.271933601787918 FDLMYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FDLMYAK 7 0 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q6PEY2;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 12519600.0 4600900.0 4687300.0 3231400.0 False True 5955955.74729768 4426447.634532157 2643318.356963947 1.0 0.7431968641708786 0.4438109464065891 22.505901604071695 -6.969107095868123 0.2786874098399437 1.0670071836428572 0.11089401030746068 0.9999745560737278 0.0011464555975207323 0.07659350904713472 0.010062865731794655 0.005572168711684741 0.027525696174097367 1.0737246020509107e-07 6.969107095868123 -0.9561131733353965 down FDLMYAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 2 FDLMYAKR 8 1 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 428908500.0 127039200.0 211580000.0 90289300.0 True False 166549621.4493629 180013088.73238057 80947029.35212213 1.0 1.0808375736063203 0.48602349646728527 27.31137683401331 -6.872586767233588 1.120254321174448 1.046523581729927 0.4494216169589946 0.9672006483821409 0.04770689925933637 0.1344021958109925 0.31366208819777597 0.03299390684274109 0.0784888502014678 1.340952001264051e-07 6.872586767233588 -0.5971019647709324 down FDLMYAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 2 FDLMYAKR 8 1 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 400309200.0 138283100.0 127474500.0 134551600.0 True False 133893378.68284212 178375732.6207357 99308499.49852349 1.0 1.33222220826364 0.7416983608559089 26.996509377135126 -6.754108280462294 1.635173380910263 1.1943863916605535 0.7401851819707377 0.6662498811870423 0.13963805007924862 0.29293010644487283 1.5422776505118299 0.06743298639624258 0.162974965572577 1.7615367965322803e-07 6.754108280462294 -0.4542012096898158 FDLMYAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 2 FDLMYAKR 8 1 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 604573900.0 202449300.0 90181600.0 311943000.0 True False 307130389.1263483 74087988.88794313 250287329.3205261 1.0 0.2412265002453553 0.8149220597560669 28.194276026452787 -10.201823402999214 7.3606548017574625 1.0000006291747017 0.5280742800031646 0.47430453908966874 0.2342102314169574 2.418174136804643e-06 2.6213947286276815e-07 0.2267733821686791 0.07559102714910512 6.283137978770536e-11 10.201823402999214 -0.4719263491715371 FDLMYAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FDLMYAKR 8 1 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 413940200.0 127039200.0 141175700.0 145725300.0 True False 174009025.34529257 134938090.76839027 111307985.44676146 1.0 0.775466045514752 0.6396678863403142 27.3745868955362 -11.99590277620795 0.062234192752321976 2.1531958054091764 7.726453816300728e-15 0.9999704867038416 0.000807180967782532 5.768638836996422 0.04755763454426811 1.373085448682904 0.47398189710213895 1.0094788488297898e-12 11.99590277620795 -2.153195805409169 FDLMYAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FDLMYAKR 8 1 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 399462900.0 138283100.0 165619000.0 95560800.0 True False 114988524.63003087 164726777.57420245 115542121.45678265 1.0 1.4325497096706095 1.0048143658554882 26.776914652569403 -10.632633715107719 2.859746860856708 0.980539207966009 1.2186820375604184 0.25844052654779615 0.17462222577136263 68904432.1187095 68677313.23979962 9960071.880309347 0.06160119223680153 2.3300556030470724e-11 10.632633715107719 0.23814282959440936 FDLMYAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FDLMYAKR 8 1 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 464516800.0 202449300.0 98996500.0 163071000.0 True False 262074609.72231337 93487257.7500825 133393751.249758 1.0 0.3567200113324174 0.5089915096738984 27.965402348545236 -10.247364419301144 8.336556419405673 1.0000003015119576 0.43285576050460645 0.9487086287878773 0.06216457888428058 3.4826590455130955e-07 3.152318753972198e-08 0.06019062607552177 0.02006353156190133 5.657643532870366e-11 10.247364419301144 -0.5671445410073512 FDLSQNHPLGMAIFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDLSQNHPLGMAIFLK 16 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 24373600.0 4972300.0 14646000.0 4755300.0 False True 6518733.4518217 12460873.889660865 4263267.172058553 1.0 1.9115483063935677 0.6540023769290885 22.63616025459722 -6.712278813934201 1.787181636478517 1.5590860144428809 0.6567605919986856 0.4759167635111945 0.3839861587732676 0.37048958734427306 2.308140188000335 0.17089489873555358 0.4329416829680893 1.9396402427041321e-07 6.712278813934201 -0.9023254224441952 FDLSQNHPLGMAIFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDLSQNHPLGMAIFLK 16 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 27851600.0 11604000.0 6105600.0 10142000.0 False True 11235637.371708464 8543597.920283377 7485505.94652181 1.0 0.7604017144409012 0.6662288661407361 23.42157863180199 -13.999999999996279 0.12903827153879988 2.1385251255601485 0.5327211968591106 0.9996499904388773 0.0026286680335442097 11.938274193005755 0.11161212761272561 3.4503616350028325 0.11869136365471256 1.000000000008569e-14 13.999999999996279 -1.605803928701038 FDLSQNHPLGMAIFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FDLSQNHPLGMAIFLK 16 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 43818800.0 4972300.0 13333000.0 25513500.0 False True 6810693.681355034 12743903.973665077 19487736.767026417 1.0 1.8711609374758418 2.8613438922346597 22.69937031612011 -6.969457341134383 0.27083323474030646 0.7563206462856267 4.005985270797847 0.9999778354571829 0.003579938590008779 0.07647917673575337 0.009658504996388474 0.019311307212597245 0.09198732635772273 1.0728590249545292e-07 6.969457341134383 3.2496646245122207 FDLSQNHPLGMAIFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FDLSQNHPLGMAIFLK 16 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 37203000.0 11604000.0 12644000.0 12955000.0 False True 9649240.144362379 12575884.262362512 15663830.602847794 1.0 1.3033030657559124 1.6233227040161782 23.201983907236265 -6.97044665271454 0.24728455266901425 0.8949872176661933 2.0409793114412054 0.9999856595624973 0.0009637464293882377 0.07615803667017873 0.008509930951029015 0.007271002052979393 0.03080883252163979 1.0704178613954795e-07 6.97044665271454 1.145992093775012 FDQK(ub)QELGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDQKQELGR 9 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6RBK5 P43243 MATR3 Matrin-3 1 22568600.0 8183900.0 7932500.0 6452200.0 True False 10729172.153000345 6749001.920642815 5784588.237872735 1.0 0.629032867065657 0.5391458124991602 23.355035428392064 -13.999999999999998 0.19911070806385736 3.0552211027384755 0.48025488456375376 0.9994869133163152 0.004518200929247916 12.513501406753766 0.14149258824453367 10.012093462123799 0.057617430502127594 1.0000000000000041e-14 13.999999999999998 -2.5749662181747217 FDQK(ub)QELGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDQKQELGR 9 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6RBK5 P43243 MATR3 Matrin-3 1 29704900.0 10005000.0 10317000.0 9382900.0 True False 9687396.75146011 14436631.902444264 6925237.009033672 1.0 1.4902488535187057 0.7148707941573551 23.207677598397094 -6.735817573563034 1.7018525633986967 1.2930967405831875 0.7148033314883301 0.5860994994309501 0.20601230374830293 0.3254315282916674 1.848973414975524 0.09582657841623296 0.2362522678944207 1.837309947722527e-07 6.735817573563034 -0.5782934090948574 FDQK(ub)QELGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FDQKQELGR 9 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6RBK5 P43243 MATR3 Matrin-3 1 95838000.0 15326000.0 25992000.0 54520000.0 True False 23250662.480682388 21353524.5235771 43744098.103035115 1.0 0.9184049934628096 1.8814129764852732 24.470768487700113 -6.886309424101744 1.0439942685056862 0.9435862395780651 1.9584830170147507 0.9784280361521048 0.06403830487931624 0.12218750434905372 0.2397622311184326 0.0469502327092088 0.11559301495243712 1.2992435692102015e-07 6.886309424101744 1.0148967774366855 FDQK(ub)QELGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FDQKQELGR 9 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6RBK5 P43243 MATR3 Matrin-3 1 32017200.0 10005000.0 14477000.0 7535200.0 True False 8319600.7966516325 14399009.527540479 9110775.481171666 1.0 1.7307332262066721 1.0950976740180196 22.98808287383137 -10.253874588830913 4.4697194487823815 0.9998090631303658 1.4129154501165344 0.3600647869094974 0.2594971275532877 0.0004939732794990709 8.245789239337334e-05 0.2513722005743905 0.08375233778155157 5.5734667063203924e-11 10.253874588830913 0.41310638698616864 FDQK(ub)QELGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FDQKQELGR 9 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6RBK5 P43243 MATR3 Matrin-3 1 94776000.0 15326000.0 22309000.0 57141000.0 True False 19839809.120625135 21067484.53881293 46741924.31617159 1.0 1.061879396657679 2.355966432538883 24.241894809792562 -6.9168660435878975 0.847641545296681 0.9680962232643556 2.5503165840224544 0.993265236332737 0.05130201925240162 0.10005110043326428 0.11542743864618853 0.043483488663642794 0.1265953122930033 1.210971595341368e-07 6.9168660435878975 1.582220360758099 up FDQLFDDESDPFEVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDQLFDDESDPFEVLK 16 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 10257600.0 3549700.0 1509800.0 5198100.0 False True 3437016.716507539 2112671.0135029857 3836561.670342642 1.0 0.6146816229773061 1.116247602729466 21.712725437840867 -6.7014472499729 1.8254459516094075 0.7610792099194008 1.1148107106264233 0.42459251448361546 0.1626041631940499 0.39250723045065117 2.543742734361164 0.0710323391305516 0.18236857386899627 1.9886243368762233e-07 6.7014472499729 0.35373150070702253 FDSEK(ub)AGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDSEKAGDR 9 1 P17980;R4GNH3;E9PM69;E9PKD5 P17980 PSMC3 26S protease regulatory subunit 6A 1 23773900.0 3228700.0 9062600.0 11482600.0 True False 4232856.966775272 7710495.405738118 10294490.700876836 1.0 1.8215818456091664 2.4320431287144375 22.013200308438712 -7.3274152807804125 0.13196884524837954 1.2405787401934081e-11 4.053967294041969 0.9999960549795903 0.0011653792782625703 0.11470394753611507 0.00831328695179835 0.0878368439829238 0.15612467339393352 4.70527184023115e-08 7.3274152807804125 4.053967294029563 FDSEK(ub)AGDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDSEKAGDR 9 1 P17980;R4GNH3;E9PM69;E9PKD5 P17980 PSMC3 26S protease regulatory subunit 6A 1 25372100.0 5967000.0 10828700.0 8576400.0 True False 5777580.851170672 15152656.380924484 6329983.553515053 1.0 2.622664532310994 1.0956114187882722 22.462034113158893 -6.631853152315782 2.0735413149792987 2.0675868566598297 1.1017803464102534 0.12423499784623415 0.6957105878483556 0.554225277546042 4.543440543096555 0.27417563700407094 0.770702952113789 2.334247206204448e-07 6.631853152315782 -0.9658065102495763 FDSEK(ub)AGDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FDSEKAGDR 9 1 P17980;R4GNH3;E9PM69;E9PKD5 P17980 PSMC3 26S protease regulatory subunit 6A 1 5670790.0 1343260.0 1526530.0 2801000.0 True False 2037823.6254600969 1254108.794666671 2247381.122278089 1.0 0.6154157695485153 1.1028339715958877 20.958597760334612 -6.6963325409083545 1.8437118010630262 0.7603411423625405 1.1013004712778205 0.40032402214273555 0.1624484481227907 0.4031879393724712 2.661835423597547 0.07035784687422827 0.1817813886853835 2.012182923851038e-07 6.6963325409083545 0.34095932891528 FDSEK(ub)AGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FDSEKAGDR 9 1 P17980;R4GNH3;E9PM69;E9PKD5 P17980 PSMC3 26S protease regulatory subunit 6A 1 19339900.0 3228700.0 3895200.0 12216000.0 True False 4422437.642336737 3723097.184296124 9330832.396417364 1.0 0.8418653885934513 2.109884446327008 22.076410369961604 -6.875653617628972 1.1038166003226948 0.9066520944518524 2.1925602948045007 0.9700042284979737 0.09771247921281019 0.13154661400535672 0.2961813847812336 0.06843936913383106 0.1638154450860872 1.3315159782868308e-07 6.875653617628972 1.2859082003526483 up FDSEK(ub)AGDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FDSEKAGDR 9 1 P17980;R4GNH3;E9PM69;E9PKD5 P17980 PSMC3 26S protease regulatory subunit 6A 1 18057600.0 5967000.0 8522000.0 3568600.0 True False 4961824.882920577 8476090.294515435 4314777.760657873 1.0 1.708260669112193 0.8695949297828007 22.24243938859317 -6.682875487826547 1.892068999800025 1.4469714650206116 0.8727415010607297 0.33718756321080967 0.2999918619923433 0.43214757681833593 2.9936111806822465 0.12712127516880273 0.33399499273179034 2.0755084801837332e-07 6.682875487826547 -0.5742299639598819 FDSK(ub)HLAAALENLNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDSKHLAAALENLNK 15 1 E7EQI7;Q12768 E7EQI7 KIAA0196 WASH complex subunit strumpellin 1 4955600.0 3290100.0 1665500.0 0.0 True False 3185657.5764096905 2330542.8354677632 0.0 1.0 0.7315735541465002 0.0 21.60315977047328 -7.367764957673605 0.7782118130958124 0.9897388773023766 4.014451248356751e-17 0.9876818309609992 0.04690227332725063 0.11048830435923188 0.13823024897890196 0.04039339123199163 0.07207535418197711 4.287805157538411e-08 7.367764957673605 -0.9897388773023766 down FDTGNLCMVTGGANLGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 FDTGNLCMVTGGANLGR 17 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 182652300.0 49883200.0 60875000.0 71894100.0 False True 65397358.26959594 51792687.28889146 64455188.18890405 1.0 0.7919691048586366 0.9855931477108316 25.962729023354935 -10.479640457379137 7.5968039456741145 1.000012391077304 0.8887811263029461 0.3055186564058817 0.07904668448711039 1.6591023584762985e-05 1.1364134346138732e-06 0.07654514669447407 0.025512207715957556 3.314053709875246e-11 10.479640457379137 -0.11123126477435785 FDTGNLCMVTGGANLGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 FDTGNLCMVTGGANLGR 17 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 73459800.0 39715400.0 10008900.0 23735500.0 False True 38454656.36611082 14005505.965723988 17518460.50026309 1.0 0.36420832453639373 0.4555614886654324 25.19665496485808 -10.754307431770771 7.034105907768905 1.0110333952717996 0.40988490660091303 0.9823437486536845 0.03729477308414472 0.00637018857962127 0.00022250250548360622 0.035646589010623946 0.012036836254623094 1.7607292064059638e-11 10.754307431770771 -0.6011484886708865 FDTGNLCMVTGGANLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FDTGNLCMVTGGANLGR 17 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 129028000.0 11417000.0 99945000.0 17666000.0 False True 17320423.694502883 82109033.87615079 14174307.356717123 1.0 4.740590376100925 0.8183580036333483 24.045970886105373 -6.65688533798405 1.9835826233676244 3.413871251032737 0.8346627925830111 0.2225831630289592 1.593841871493011 0.49188065504875955 3.7169511040564833 0.6498673262368543 1.7667046342928414 2.203508154387917e-07 6.65688533798405 -2.579208458449726 FDTGNLCMVTGGANLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FDTGNLCMVTGGANLGR 17 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 143732900.0 49883200.0 40212400.0 53637300.0 False True 68326367.08279249 38435683.203375794 40969274.43486879 1.0 0.5625307600037109 0.5996114850541587 26.025939084877827 -10.656900548400898 5.7323294968397365 1.0045225272250755 0.5810711225289406 0.9941583874817448 0.015138142611005944 0.0008812566858394507 5.274616072556805e-05 0.014762977244301295 0.004885814518744897 2.2034309816582687e-11 10.656900548400898 -0.42345140469613496 FDTGNLCMVTGGANLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FDTGNLCMVTGGANLGR 17 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 52086100.0 29921000.0 7217100.0 14948000.0 False True 24880637.22504886 7178220.049817815 18073557.68825695 1.0 0.28850627839189996 0.7264105627512303 24.56852009942464 -10.50367343159613 7.78707543640655 1.0000672218513977 0.5074584205729951 0.6278114076777763 0.17877367547649795 0.00020866464945497803 1.330000616600413e-05 0.17312023788667827 0.057698955655063784 3.135642689387534e-11 10.50367343159613 -0.4926088012784027 FDTGNLCMVTGGANLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FDTGNLCMVTGGANLGR 17 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 68538800.0 16479900.0 31948100.0 20110800.0 False True 21333555.41739463 30170160.150363054 16450840.754233615 1.0 1.4142115348369624 0.7711251327952667 24.34662108725487 -6.732802684878098 1.7132486899951505 1.2484887557879643 0.7713233121769298 0.5721482101777517 0.17408872021916966 0.33098769878837286 1.9045836914261596 0.08048764790269032 0.19907593765594922 1.8501089970661407e-07 6.732802684878098 -0.4771654436110344 FDTIYQILLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDTIYQILLK 10 0 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 0 16984100.0 5817100.0 5573600.0 5593400.0 False True 7626274.432876542 4742040.605722633 5014648.623681434 1.0 0.6218030373100526 0.6575489339937072 22.862547016966523 -9.702532456757025 5.9578805605921525 1.0000000067071904 0.6396759860946372 0.9926728772912539 0.014593201222771246 1.3020344730340587e-09 2.827186964355261e-10 0.014129806531821009 0.004709935440423535 1.983661403462916e-10 9.702532456757025 -0.3603240206125532 FDTIYQILLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDTIYQILLK 10 0 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 0 14970300.0 6183600.0 3605600.0 5181100.0 False True 5987305.002731516 5045334.882955611 3824014.4803317045 1.0 0.8426721004949369 0.6386871018909377 22.513475334590815 -6.96756593919835 0.310878133496859 1.0311014768645952 0.44376537793423554 0.9999566894316411 0.0009734211659647419 0.07710068979464402 0.011843076903974764 0.0032147277810949623 0.018094636041229323 1.0775416374639786e-07 6.96756593919835 -0.5873360989303597 FDTIYQILLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FDTIYQILLK 10 0 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 0 21387100.0 5817100.0 6356800.0 9213200.0 False True 7967839.071216618 6075935.556873489 7037231.911810121 1.0 0.7625575143482094 0.8832045739015658 22.925757078489415 -10.142278489171717 4.90398399527973 1.0000110157085784 0.8228810441242346 0.7418461911142571 0.04925395581440657 5.932405050971122e-06 1.0375384558560823e-06 0.047692903243996054 0.01589664588334747 7.206452208326083e-11 10.142278489171717 -0.17712997158434385 FDTIYQILLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FDTIYQILLK 10 0 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 0 11559500.0 6183600.0 2892900.0 2483000.0 False True 5141937.379927547 2877315.3735043057 3002183.819905144 1.0 0.5595780657960577 0.5838623845604761 22.29388061002509 -10.490918790169601 6.137629391695413 1.0003214961447777 0.5717202251782677 0.9975944623481504 0.009914031620653407 4.3646102015137015e-05 3.6201749049950677e-06 0.009606226314514533 0.00319973994671368 3.229097882492208e-11 10.490918790169601 -0.42860127096651 FDTIYQILLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FDTIYQILLK 10 0 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 0 5428400.0 2084200.0 3344200.0 0.0 False True 2698037.985724061 3158092.3302119384 0.0 1.0 1.1705144059950716 0.0 21.363479229482092 -6.927407181635693 1.2450645788818726 1.0907387857823907 2.5452173485907318e-21 0.9628681709541161 0.09949087578912606 0.11828092223591759 0.3663940257079558 0.06590353339806024 0.1277855035409136 1.1819328908294485e-07 6.927407181635693 -1.0907387857823907 down FDTIYQILLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDTIYQILLKK 11 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 16147200.0 6855300.0 4235200.0 5056700.0 True False 6637682.253901496 5926337.44627623 3732198.572251706 1.0 0.8928323501464458 0.5622743646787243 22.662248138527602 -6.9508245276100515 0.5497166661471349 1.0045792112137517 0.43500590553629576 0.9992644127304344 0.005052674692008322 0.08315632756883289 0.03460507591772218 0.005486051197331238 0.02742112187066366 1.1198902726575074e-07 6.9508245276100515 -0.5695733056774559 FDTIYQILLKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDTIYQILLKK 11 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 5548970.0 1401400.0 3434700.0 712870.0 True False 1837248.9711769042 2922256.1483557373 639109.0507318962 1.0 1.5905607754858613 0.3478619723066145 20.809115712999194 -6.777469919105574 1.5456308897308353 1.335489943115448 0.338771637727315 0.7583617293874376 0.24948863322626438 0.2545291202778981 1.2008428164957805 0.12715484322333864 0.3006849771981374 1.6692834241520758e-07 6.777469919105574 -0.9967183053881331 down FDTQYPYGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDTQYPYGEK 10 0 P30040;F8W1G0 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 11251800.0 4024100.0 1302600.0 5925100.0 False True 3896357.1481809784 1822734.9729692629 4373138.560810138 1.0 0.4678049017709298 1.1223659419547167 21.893694493226494 -6.690503115553319 1.8648288612933257 0.6664956536419797 1.1201031538893178 0.3726510867853007 0.22505958493225295 0.4156103063803094 2.8026668908586245 0.09653776153041269 0.25121311277821323 2.039374029440421e-07 6.690503115553319 0.4536075002473381 FDVQK(ub)ALSGVLEQDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDVQKALSGVLEQDR 15 1 Q9Y450;Q9Y450-4;E9PN23;G5E991;E9PMN1;E9PLR4;Q9Y450-2;E9PJ90 Q9Y450 HBS1L HBS1-like protein 1 23314400.0 6848300.0 7604300.0 8861800.0 True False 6630904.465069888 10640736.645900639 6540628.73169858 1.0 1.6047187381380088 0.9863856078990642 22.660774238798393 -6.651275534292003 2.004164274469763 1.3920095300564495 0.9889938431155848 0.1991890672826555 0.25802056673807594 0.5053972253400829 3.8926024510853727 0.10436332452189245 0.28577851594469356 2.2321556021220904e-07 6.651275534292003 -0.40301568694086465 FDVQK(ub)ALSGVLEQDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FDVQKALSGVLEQDR 15 1 Q9Y450;Q9Y450-4;E9PN23;G5E991;E9PMN1;E9PLR4;Q9Y450-2;E9PJ90 Q9Y450 HBS1L HBS1-like protein 1 16576600.0 6848300.0 6595600.0 3132700.0 True False 5694664.881130369 6560068.193675902 3787733.086031755 1.0 1.1519673818582548 0.665137135388361 22.44117951423267 -6.822800292349706 1.359494560348774 1.0816852238072516 0.6538362828535439 0.8907667197324541 0.06721441915484887 0.18985223277118832 0.6886673305879953 0.03884234690272685 0.08947534582720403 1.5038333356404556e-07 6.822800292349706 -0.42784894095370773 FDVQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDVQLK 6 0 P62244;I3L3P7;H3BVC7 P62244 RPS15A 40S ribosomal protein S15a 0 27351000.0 6159000.0 12001000.0 9191000.0 False True 8074508.643840845 10210497.57953161 8240003.486297431 1.0 1.2645348503428846 1.0204959644922573 22.944943039822718 -10.755380003198766 2.926984422113682 0.9725982086786886 1.1425154074142079 0.312582604672204 0.09962845858556124 174293998.67785758 113243841.53820354 33936011.42316611 0.03646028419482139 1.7563861216448023e-11 10.755380003198766 0.16991719873551925 FDVQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDVQLK 6 0 P62244;I3L3P7;H3BVC7 P62244 RPS15A 40S ribosomal protein S15a 0 15512900.0 4935600.0 3447700.0 7129600.0 False True 4778922.079610852 4824384.589517983 5262143.87658469 1.0 1.0095131306076521 1.1011152282719763 22.188253813938168 -6.9268212200204795 0.7724461636242609 0.9984304997440118 1.1184833505781895 0.9958755160974816 0.002927858475607382 0.09432278229193038 0.08601740037744934 0.0026185879921224865 0.008437952558483078 1.183528662270104e-07 6.9268212200204795 0.12005285083417772 FDVQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FDVQLK 6 0 P62244;I3L3P7;H3BVC7 P62244 RPS15A 40S ribosomal protein S15a 0 47516000.0 3042900.0 41437000.0 3036100.0 False True 4616301.7657881025 34042243.60124126 2436013.5042300997 1.0 7.3743540453815015 0.5276980639098708 22.13830610478421 -6.662248060806566 1.9647218484413616 5.0955860515193825 0.5560954873500519 0.2451427852861523 2.7126299555153564 0.4792345482491189 3.558443849467754 1.1144984280396384 3.0082312596143153 2.1764662608254255e-07 6.662248060806566 -4.539490564169331 FDVQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FDVQLK 6 0 P62244;I3L3P7;H3BVC7 P62244 RPS15A 40S ribosomal protein S15a 0 33144000.0 6159000.0 15010000.0 11975000.0 False True 8436148.740716698 14346808.568567654 9146751.632866565 1.0 1.700634852408827 1.0842330918989342 23.00815310134561 -10.434277604428553 4.551641969452114 0.9989561936559593 1.3924339721537644 0.3508330972675483 0.25164496496854005 0.002673374551185867 0.0003322728829647126 0.24427292169798556 0.08121806320646857 3.6789373791447014e-11 10.434277604428553 0.3934777784978051 FDVQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FDVQLK 6 0 P62244;I3L3P7;H3BVC7 P62244 RPS15A 40S ribosomal protein S15a 0 8739600.0 4935600.0 2143800.0 1660200.0 False True 4104170.0841533076 2132250.9238890167 2007340.1441025021 1.0 0.5195327874256218 0.48909769891191474 21.968659089372444 -13.999999999999996 0.39232337564718694 8.710259578784767 0.4869816763228384 0.99982662584068 0.003081086147521568 25.67043986478415 0.2055679321551516 167.99442467365455 0.007957328117148003 1.0000000000000082e-14 13.999999999999996 -8.223277902461929 FDVQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FDVQLK 6 0 P62244;I3L3P7;H3BVC7 P62244 RPS15A 40S ribosomal protein S15a 0 8102000.0 3042900.0 2857300.0 2201800.0 False True 3939094.0345263104 2698288.7432314367 1801094.9923758162 1.0 0.6850023684585421 0.4572358457526399 21.90943242687666 -7.753621010788331 0.15437901545806654 1.3151661627039928 5.251819438163624e-16 0.9999660876809114 0.0012959002861068986 0.1317514018141944 0.01999042608652994 0.06276890877309843 0.09136954209754697 1.7635143145494153e-08 7.753621010788331 -1.3151661627039923 down FDVQLK(ub)DLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDVQLKDLEK 10 1 P62244;I3L3P7;H3BVC7 P62244 RPS15A 40S ribosomal protein S15a 1 106236000.0 38376000.0 28800000.0 39060000.0 True False 50311307.6337126 24503152.26152074 35018445.889976926 1.0 0.4870307176254284 0.6960352957813358 25.584379351194446 -10.222724135718126 5.499427033321865 1.0000217062633707 0.5915330067033544 0.8358669371808207 0.08532576173136969 2.270952588204352e-05 3.2097624241421154e-06 0.0826206973588846 0.027538771182323642 5.98791827443027e-11 10.222724135718126 -0.4084886995600163 FDVQLK(ub)DLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FDVQLKDLEK 10 1 P62244;I3L3P7;H3BVC7 P62244 RPS15A 40S ribosomal protein S15a 1 191431000.0 38683000.0 62239000.0 90509000.0 True False 58684939.106109686 51131964.17447345 72619856.47849603 1.0 0.871296195468832 1.2374530430574406 25.806486962012634 -6.811730993833219 1.4073062069460716 0.9299993022021833 1.2441114884763422 0.8642764794793587 0.05587427240694781 0.2044553692495229 0.7977499968008567 0.03121608005801428 0.07215214822370893 1.5426556928061573e-07 6.811730993833219 0.31411218627415893 FDVQLK(ub)DLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FDVQLKDLEK 10 1 P62244;I3L3P7;H3BVC7 P62244 RPS15A 40S ribosomal protein S15a 1 79025400.0 38376000.0 23292400.0 17357000.0 True False 52564644.27240519 22263264.75033351 13257634.078635903 1.0 0.4235406718432038 0.2522158051699353 25.647589412717338 -13.999999999999998 0.17005703936699074 3.9075348175137665 0.10117940843335856 0.9995135693435282 0.007054737628430871 12.092078899086061 0.1305887489521204 11.597978830872362 0.13960655615384074 1.0000000000000041e-14 13.999999999999998 -3.806355409080408 FDVQLK(ub)DLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FDVQLKDLEK 10 1 P62244;I3L3P7;H3BVC7 P62244 RPS15A 40S ribosomal protein S15a 1 96148000.0 31171000.0 48076000.0 16901000.0 True False 25920067.609438106 47817005.04566116 20434920.95860525 1.0 1.8447870494076128 0.7883822398350695 24.627566145538776 -6.693749633707997 1.8532378867667505 1.5277550128944626 0.7918721667068016 0.38800080857188535 0.3570177024431538 0.4086386839976827 2.7239286014146575 0.15395461540732858 0.3990025486116224 2.0241857646110762e-07 6.693749633707997 -0.735882846187661 FDVQLK(ub)DLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FDVQLKDLEK 10 1 P62244;I3L3P7;H3BVC7 P62244 RPS15A 40S ribosomal protein S15a 1 381130000.0 38683000.0 58367000.0 284080000.0 True False 50075906.05592733 55118825.14128354 232380354.90695003 1.0 1.100705498563002 4.640562162717851 25.577613284105084 -6.912987495326367 0.8751496667150209 0.9004819531327996 5.1285032181578165 0.9920008648795996 0.15141299222163274 0.10247526387275999 0.12829866415066132 0.1258249519740459 0.354958990355151 1.2218348400407106e-07 6.912987495326367 4.228021265025017 up FDVQLK(ub)DLEK(ub)WQNNLLPSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FDVQLKDLEKWQNNLLPSR 19 2 P62244;I3L3P7;H3BVC7 P62244 RPS15A 40S ribosomal protein S15a 2 13273000.0 3354300.0 7499800.0 2418900.0 True False 2789249.070685516 7459397.088806249 2924680.8062700527 1.0 2.6743388273220603 1.0485549092793105 21.411445337322068 -6.639327605117494 2.0467269822423138 2.095495606693228 1.0553054512915592 0.15200599706094065 0.7165247658043826 0.5351416055108708 4.283597668105975 0.28515921331858973 0.793502988431794 2.2944172275389857e-07 6.639327605117494 -1.040190155401669 FDVSGYPTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDVSGYPTLK 10 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 23780500.0 1697700.0 12911000.0 9171800.0 False True 2225701.140550187 10984729.126683814 8222790.118118039 1.0 4.935401670310696 3.694471808593938 21.08582845490952 -9.07176592015364 9.702278675101866 1.0000000000007574 4.314936739464763 0.9048949834889832 0.5066074946854787 42249100.9382344 39503498.4972354 0.4905205974708349 0.17342522104031866 8.476841832837088e-10 9.07176592015364 3.314936739464005 FDVSGYPTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDVSGYPTLK 10 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 17094400.0 5836400.0 2309200.0 8948800.0 False True 5651126.676683839 3231275.6023189155 6604840.821754517 1.0 0.5717931639456848 1.1687653099346784 22.43010709858987 -6.714146956827044 1.780129485211387 0.7378779333833709 1.1675606211446217 0.4849276551278855 0.18033107507781232 0.36678968536155754 2.268109576629757 0.08053438656906634 0.20359539090800208 1.9313146870141442e-07 6.714146956827044 0.42968268776125074 FDVSGYPTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FDVSGYPTLK 10 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 19414100.0 1697700.0 9934800.0 7781600.0 False True 2325385.5686174277 9495847.686009731 5943746.347082629 1.0 4.083558363035488 2.5560261606923618 21.149038516432412 -9.086643413997818 10.846305763409356 0.999999342932602 3.3197922618694116 0.7546059420997239 0.6236124102367463 0.0 0.0 0.6038101198330452 0.20127003994434836 8.191370806633477e-10 9.086643413997818 2.31979291893681 FDVSSTSVFK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDVSSTSVFKQR 12 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 14996800.0 3582100.0 5069800.0 6344900.0 True False 4696167.789105742 4313405.601925622 5688390.612578451 1.0 0.9184947803466351 1.2112835120104706 22.16305252466019 -6.832441323218963 1.3171166719529643 0.9565187242349131 1.2195539172802778 0.9106419632582965 0.03688248720420607 0.17781903339387048 0.6024615166493467 0.02198152207480978 0.05058124846681047 1.4708171215542656e-07 6.832441323218963 0.2630351930453647 FDVSSTSVFK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDVSSTSVFKQR 12 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 17626200.0 3771700.0 7205800.0 6648700.0 True False 3651969.4480242007 10083113.517750578 4907206.013275443 1.0 2.761007084329737 1.34371496889996 21.80024326526834 -6.592165873959383 2.2211795442014264 2.190280553264933 1.3479931418654125 0.0 0.7626873349545591 0.6631399713106765 6.1715060660107035 0.2863368071432338 0.8494084130653291 2.557608850006686e-07 6.592165873959383 -0.8422874113995205 FDVSSTSVFK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FDVSSTSVFKQR 12 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 37811000.0 12358000.0 11914000.0 13539000.0 True False 18747989.490817767 9787853.615493117 10863010.715645505 1.0 0.52207484009349 0.5794227013497047 24.160232555438885 -10.17413548353492 5.138295019405541 1.0000242236008174 0.5507487707245825 0.9879262626363949 0.02341216633516723 6.877636645275536e-06 1.1054091667760277e-06 0.02267002421521189 0.007556244190560227 6.696756632209537e-11 10.17413548353492 -0.44927545287623494 FDVSSTSVFK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FDVSSTSVFKQR 12 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 13847100.0 3582100.0 6148600.0 4116400.0 True False 4906499.172612642 5876934.521298811 3144191.099919156 1.0 1.1977856949621017 0.6408216916594156 22.226262586183083 -6.8106872454628276 1.4114793057811283 1.1077042016626013 0.6309077169309366 0.8616600539415618 0.08574713068635782 0.20585988374775088 0.8081740291359236 0.04776451304874358 0.11046354736966635 1.54636764593748e-07 6.8106872454628276 -0.4767964847316647 FDVSSTSVFK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FDVSSTSVFKQR 12 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 14153300.0 3771700.0 5839700.0 4541900.0 True False 3136335.664640778 5808240.377010305 5491590.290627127 1.0 1.851919245281278 1.7509574477437537 21.580648540702615 -10.306515617428904 5.513093347128377 0.9998796001398655 1.8014383465125337 0.9882375835890753 0.04121748124691587 6.1005455575228986e-05 7.673791469266198e-06 0.03991455527264068 0.013302884870151023 4.9372416338291996e-11 10.306515617428904 0.8015587463726681 FDVSSTSVFK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FDVSSTSVFKQR 12 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 41451000.0 12358000.0 14805000.0 14288000.0 True False 15997674.612598559 13981088.735359065 11687730.607260281 1.0 0.8739450622622751 0.730589344407337 23.931358877531334 -6.969449919524037 0.2710038689246063 1.0352063167551866 0.5650126028389187 0.9999777654179566 0.0005189494336004108 0.07648156939728129 0.009667166192625849 0.002792928139330653 0.013314538327307142 1.0728773590803474e-07 6.969449919524037 -0.47019371391626785 FDYVMQFLNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FDYVMQFLNK 10 0 O94925-3;O94925 O94925-3 GLS Glutaminase kidney isoform, mitochondrial 0 8375500.0 2625300.0 2729400.0 3020800.0 False True 3441793.7234413642 2322184.15911787 2708236.5935597103 1.0 0.6747017240754265 0.7868677820853864 21.714729204446087 -10.93466600949016 11.109983022782789 1.0506104415868935 0.7307847530804312 0.8848052771725102 0.04579160143063663 0.025516534902509137 0.00015005375694761226 0.01970842282038314 0.014779175811418625 1.162342159647725e-11 10.93466600949016 -0.3198256885064623 FDYVMQFLNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FDYVMQFLNK 10 0 O94925-3;O94925 O94925-3 GLS Glutaminase kidney isoform, mitochondrial 0 7219600.0 2705200.0 1287700.0 3226700.0 False True 2619324.906751613 1801885.32526679 2381530.471074931 1.0 0.6879197462759287 0.9092153726085147 21.320763595139546 -10.052947354820114 5.66952926862108 1.0000008605711659 0.7985675606641341 0.5248772382300009 0.09034356113759681 9.827743611717548e-07 1.6415642362459442e-07 0.08747515101822026 0.029158258976887872 8.852229100540797e-11 10.052947354820114 -0.20143329990703174 FDYVMQFLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FDYVMQFLNK 10 0 O94925-3;O94925 O94925-3 GLS Glutaminase kidney isoform, mitochondrial 0 9307000.0 2625300.0 2670000.0 4011700.0 False True 3595944.356064871 2552030.5714907153 3064219.0835549696 1.0 0.7096969026193343 0.8521319520383844 21.77793926596898 -10.116388455945154 4.845405679162448 1.0000114592794502 0.7809144273274167 0.7592979967246918 0.058148865432438135 7.198700825832811e-06 1.3127703842972506e-06 0.056305340819447366 0.018767465617682583 7.649121229949524e-11 10.116388455945154 -0.21909703195203356 FDYVMQFLNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FDYVMQFLNK 10 0 O94925-3;O94925 O94925-3 GLS Glutaminase kidney isoform, mitochondrial 0 6866800.0 2705200.0 1667100.0 2494500.0 False True 2249493.6606798596 1658119.0014065583 3016088.4167351522 1.0 0.7371076568872964 1.34078547072838 21.101168870573822 -6.788333486361207 1.502884974872697 0.852750642751971 1.3469232753839737 0.7959099810155952 0.11164576011504183 0.23784512772621338 1.061291353784701 0.0584775530066174 0.1370841995390459 1.6280454078493027e-07 6.788333486361207 0.49417263263200273 FEAHPNDLYVEGLPENIPFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEAHPNDLYVEGLPENIPFR 20 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 0 9486700.0 2577500.0 1306000.0 5603200.0 False True 2495678.673352169 1827492.6107000287 4135553.827603138 1.0 0.7322627829508838 1.6570858547459983 21.251000763859462 -6.829254573947153 1.3311618059724504 0.8568597988411414 1.6816079827624444 0.9043852604810955 0.12014613048596638 0.1817364189060578 0.630068554508746 0.070869699718204 0.16310286575669927 1.48164932004969e-07 6.829254573947153 0.824748183921303 FEDCSSAK(ub)TILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FEDCSSAKTILK 12 1 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 1 27016400.0 2872700.0 2272700.0 21871000.0 True False 3718766.77938274 2146222.2471361407 17890702.415410817 1.0 0.5771327901053214 4.8109234799554725 21.82639284220594 -6.882326803513165 1.0667900638084056 0.7289344248524989 5.124620990487125 0.975512156029355 0.29794916941257427 0.12558658734328854 0.26002894559857226 0.21468531823907622 0.5223497793558141 1.3112128493352742e-07 6.882326803513165 4.395686565634627 up FEDENFILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FEDENFILK 9 0 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 332735000.0 14535000.0 173240000.0 144960000.0 False True 19055525.75714023 147393267.28423086 129960929.75450735 1.0 7.734935743192582 6.820117765882693 24.18370607801656 -9.18983281894786 10.407096252513265 0.9999999679878249 7.277526748800221 0.9843219988812042 0.37347287532343343 0.0 0.0 0.36161355659648525 0.1205378521988284 6.459028205696427e-10 9.18983281894786 6.277526780812396 FEDENFILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEDENFILK 9 0 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 293872000.0 116220000.0 40892000.0 136760000.0 False True 112530659.71561153 57220388.84896287 100938453.28794347 1.0 0.5084871002584606 0.8969862395105122 26.745742885815762 -9.886475507656444 6.58837782639651 1.0000000137031773 0.7027366698844747 0.4383987784396932 0.15860410944637757 3.1941684426244735e-08 5.209943166078158e-09 0.15356777549645736 0.051189256210483224 1.2987468055058134e-10 9.886475507656444 -0.29726334381870256 FEDENFILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FEDENFILK 9 0 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 681171400.0 8530000.0 666130000.0 6511400.0 False True 12940633.626531463 547253897.0025551 5224418.935951999 1.0 42.28957505454376 0.40372203454092565 23.625404923541538 -4.181032148383997 14.349125672968228 9.999999999999998 18.31583688092493 0.0 20.130451294770403 0.0 0.0 6.933603006677858 0.0 6.591251021049472e-05 4.181032148383997 8.315836880924932 FEDENFILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FEDENFILK 9 0 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 354005000.0 14535000.0 138060000.0 201410000.0 False True 19908982.29360565 131960052.69663249 153841106.16915697 1.0 6.628166661186659 7.727221005092134 24.24691613953945 -9.410985615799655 0.5113026348954902 1.0010854101749511e-18 7.709056926128274 0.9981914054984609 0.12530983843975008 0.7523177463934498 0.21778640236821645 1.7638191937304006 0.21713175788093877 3.881632220717701e-10 9.410985615799655 7.709056926128274 FEDENFILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FEDENFILK 9 0 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 133981000.0 116220000.0 17761000.0 0.0 False True 96642079.41897573 17665317.967717513 0.0 1.0 0.18279116171675544 0.0 26.52614816125004 -9.631877033655497 0.44429245310004883 1.2464586172664271 9.036540543669934e-22 0.9980678790675865 0.019110807609904946 1.052421595307497 0.21194697895606876 0.4399426302957286 0.04228899083414563 2.3341188522414397e-10 9.631877033655497 -1.2464586172664271 FEDENFILK(ub)HTGPGILSMANAGPNTNGSQFFICTAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FEDENFILKHTGPGILSMANAGPNTNGSQFFICTAK 36 1 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 101601000.0 12686000.0 31564000.0 57351000.0 True False 19245589.47082979 25931157.589342408 46015549.7121637 1.0 1.3473818314916164 2.390965981162005 24.198024524168755 -6.9514199644796015 0.5430349077705218 0.9849350255977425 2.8018565045758974 0.9993080328268905 0.015548883885094268 0.08292059787834255 0.03364155517104862 0.017031606984861346 0.08646647148784917 1.1183559058343392e-07 6.9514199644796015 1.816921478978155 up FEDENFILK(ub)HTGPGILSMANAGPNTNGSQFFICTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FEDENFILKHTGPGILSMANAGPNTNGSQFFICTAK 36 1 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 89211000.0 12686000.0 27534000.0 48991000.0 True False 16422277.078445185 26001708.69566876 40075140.69010981 1.0 1.5833193272446313 2.4402913492861376 23.969150846261204 -6.965600497262114 0.34759200991946987 0.9148554882107569 3.137565951613745 0.9999249942279977 0.005122938618107606 0.07775776035848501 0.01414472669825227 0.011837284234892297 0.07377825994917045 1.0824292082396075e-07 6.965600497262114 2.222710463402988 FEDSPSYVK(ub)WGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FEDSPSYVKWGK 12 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 1 23881300.0 7347600.0 3096700.0 13437000.0 True False 9511613.042849116 2924365.9227819275 10991603.87526292 1.0 0.3074521544987033 1.155598301334017 23.181258593016004 -6.6895702428564805 1.8675052082636332 0.5656632868274771 1.1526928776858505 0.36867731668560755 0.29292103321937907 0.4175548489227138 2.8229749818494554 0.12548274336347154 0.32699565460509594 2.0437593513160195e-07 6.6895702428564805 0.5870295908583734 FEEHVQSVDIAAFNKI ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEEHVQSVDIAAFNKI 16 1 P29692;E9PRY8;P29692-2;P29692-4;E9PQZ1;H0YE72;P29692-3 P29692;P29692-3 EEF1D Elongation factor 1-delta 0 9167200.0 1678900.0 2900800.0 4587500.0 False True 1625604.2384833954 4059104.5674721627 3385896.1279499936 1.0 2.496982027593073 2.0828538999805137 20.632544638130923 -10.298191172222197 5.40523522112405 0.999792459650972 2.2899179637867877 0.9282423943357382 0.16906710013102721 0.00042292404499466905 5.491242275932067e-05 0.16372374403676454 0.054566171933225376 5.032790214732008e-11 10.298191172222197 1.2901255041358157 FEELCSDLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FEELCSDLFR 10 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066;P48741 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6;HSPA7 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 20190900.0 2168500.0 8222900.0 9799500.0 False True 2842924.499783871 6996075.372613154 8785541.743441595 1.0 2.460872729172027 3.0903183479228877 21.438944354856062 -9.445249474195807 0.2511585508166459 1.6747742389048396e-15 3.478170808390392 0.9990859076590942 0.026472285966177195 0.8501394005255296 0.09891969940064425 0.9585360127112895 0.27292492758171893 3.5871581632743334e-10 9.445249474195807 3.47817080839039 FEELCSDLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEELCSDLFR 10 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066;P48741 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6;HSPA7 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 7219200.0 3992600.0 1142600.0 2084000.0 False True 3865857.098438749 1598846.1385802852 1538137.881340117 1.0 0.4135812829775807 0.3978775837216807 21.882356878579447 FEELCSDLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FEELCSDLFR 10 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066;P48741 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6;HSPA7 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 22299000.0 2168500.0 11859000.0 8271500.0 False True 2970253.0515090358 11335030.167531237 6317942.056889839 1.0 3.8161833254484767 2.1270719858969627 21.502154416378954 -10.13708004599686 6.059936803568946 0.9999883698978544 2.971627655672745 0.6449686935742334 0.6895768167751214 0.00010835126293243903 1.543146187473808e-05 0.6676838037952687 0.22255996060838415 7.293230743468719e-11 10.13708004599686 1.9716392857748903 FEELNADLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FEELNADLFR 10 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;P54652;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 127497000.0 23596000.0 49014000.0 54887000.0 False True 30934584.50398903 41701302.2550756 49207819.75328118 1.0 1.3480479186555165 1.590705695333836 24.88271732082156 -7.024148237128525 0.07199231236284366 0.00011001205588292832 2.9327900227057504 0.9999999414208235 5.839106929196763e-05 0.07189923093767353 0.0020789145415153203 0.033540970453536954 0.050722293627500685 9.459142386725043e-08 7.024148237128525 2.9326800106498676 FEELNADLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEELNADLFR 10 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;P54652;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 111433000.0 37933000.0 19286000.0 54214000.0 False True 36728837.67847442 26987000.375161353 40013727.01486231 1.0 0.734763256365653 1.0894362453052266 25.130409905447625 -6.706535348649261 1.807606503630404 0.8363650668855144 1.0885194836223353 0.4486355184547668 0.11183162638801639 0.3820691438994465 2.431307456304546 0.049274908298431175 0.1257077554798314 1.9654619986850044e-07 6.706535348649261 0.25215441673682093 FEELNADLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FEELNADLFR 10 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;P54652;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 175997700.0 6500700.0 156750000.0 12747000.0 False True 9862037.164829187 128776737.8066601 10227549.862791417 1.0 13.057823211812094 1.0370625958768187 23.23345425893199 -6.645471141357774 2.024642530252058 8.852253680471005 1.087399797291493 0.17587593018552572 5.152197833139251 0.5197508084731838 4.078377680227061 2.0675067331363723 5.706052725367719 2.2621888560471202e-07 6.645471141357774 -7.764853883179512 FEELNADLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FEELNADLFR 10 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;P54652;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 137623000.0 23596000.0 51567000.0 62460000.0 False True 32320078.857923537 49288599.430734836 47708234.40407893 1.0 1.5250148258425837 1.476117512392234 24.94592738234445 -10.087353946666004 4.83296908326434 0.9999805612358725 1.5005661691222496 0.9928942275722596 0.019962244641064362 13878049.10339743 0.4298940047683643 3002.133917846645 0.006833607302699406 8.177980173642761e-11 10.087353946666004 0.5005856078863771 FEELNADLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FEELNADLFR 10 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;P54652;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 68810000.0 37933000.0 18272000.0 12605000.0 False True 31542970.216830242 18173565.10929198 15240647.221064955 1.0 0.5761526255886704 0.48317096063873755 24.9108151808819 -13.999999999999998 0.2131771570311607 3.4838389857457313 0.4300623718285703 0.9994920321032965 0.005069851379369914 12.82292054060254 0.1463195812157774 13.36101431738 0.05387679525477804 1.0000000000000041e-14 13.999999999999998 -3.0537766139171607 FEELNADLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FEELNADLFR 10 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;P54652;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 31237200.0 6500700.0 14755000.0 9981500.0 False True 8415284.297954319 13933871.279312579 8164969.418838784 1.0 1.6557814074920534 0.9702547329058884 23.004580581024438 -6.656237091412622 1.9862541054338139 1.4234202733224115 0.9731279085306015 0.21972869089505032 0.2794700312877638 0.4934288814802832 3.7381180511213308 0.11383462393234109 0.3096915311964902 2.206799661082842e-07 6.656237091412622 -0.45029236479181 FEELNMDLFR ddPTM_RPMI8226_Bortezomib_1h_R1 2 FEELNMDLFR 10 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 35350140.0 7738640.0 11864100.0 15747400.0 False True 10145431.981096352 10094022.525899597 14118010.107727148 1.0 0.9949327485224341 1.3915632310218795 23.274326958948034 -6.904007459703698 0.9355860075182634 0.9852730121044779 1.436757196739241 0.98845657502398 0.01996139836235552 0.10851568555548922 0.16125154020827798 0.015873096725937102 0.04219458712089462 1.247362088616122e-07 6.904007459703698 0.45148418463476303 FEELNMDLFR ddPTM_RPMI8226_Bortezomib_2h_R1 2 FEELNMDLFR 10 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 29917000.0 12964000.0 3735300.0 13217700.0 False True 12552464.916134818 5226824.769332176 9755587.847499639 1.0 0.41639827748999847 0.7771850319979704 23.58146735692183 -10.65072950814941 5.18113379546825 1.0062504654593183 0.5967916547440393 0.6248099315021642 0.14729057574988805 0.010739426930198007 0.0007239651551376069 0.14402167269304914 0.04753782891105105 2.2349637930526435e-11 10.65072950814941 -0.409458810715279 FEELNMDLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FEELNMDLFR 10 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 42761040.0 7738640.0 22772100.0 12250300.0 False True 10599824.336882576 21765953.32473548 9357031.44284804 1.0 2.053425852445483 0.8827534443462255 23.337537020470926 -6.669601535989355 1.9388537061484221 1.672626189783319 0.8874992079181302 0.2772798570197287 0.44751300891781165 0.4620162400539448 3.3480096941488156 0.18584598785221226 0.4967796787755747 2.1399245640725054e-07 6.669601535989355 -0.7851269818651888 FEELNMDLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FEELNMDLFR 10 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 20219500.0 10873000.0 5058800.0 4287700.0 False True 9041381.255571542 5031547.240306815 5184238.245915139 1.0 0.5565020540646088 0.5733900716464613 23.108111759922643 -10.013015472848425 7.410657506359335 1.000000021102748 0.5649460628685956 0.9988711345810486 0.006894504307115144 2.3942031108821797e-09 3.221538572748606e-10 0.006675575388873577 0.0022251916968176596 9.704753909689189e-11 10.013015472848425 -0.4350539582341524 FEETTADGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEETTADGR 9 0 Q01469;I6L8B7 Q01469 FABP5 Fatty acid-binding protein, epidermal 0 3283010.0 976660.0 482650.0 1823700.0 False True 945656.4628966562 675374.6619864992 1346018.2601727312 1.0 0.7141860585584618 1.4233691757889753 19.850956652411117 -6.797308327554788 1.4667983092499637 0.8417583366406765 1.4325287679145144 0.8241865918774187 0.12215604664170342 0.2246293484400875 0.9543754215945492 0.06552416369600693 0.15264704183767622 1.5947465542376834e-07 6.797308327554788 0.590770431273838 FEEYEWCGQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 FEEYEWCGQKR 11 1 Q5TDE7;Q5TDE8;Q5VTB9-3;Q5VTB9;H0Y7B1 Q5TDE7 RNF220 E3 ubiquitin-protein ligase RNF220 1 16782500.0 7870100.0 6948500.0 1963900.0 True False 10317777.31415681 5911810.88504086 1760694.4670590295 1.0 0.5729732969647819 0.17064668226975754 23.298628878847467 -7.7604791144603125 0.3752614484480876 1.0591051947785544 8.973048489822106e-21 0.9985526554059616 0.012882913242358714 0.11699008490704402 0.062334555387380475 0.032833386192646676 0.07834213708643624 1.735884740832627e-08 7.7604791144603125 -1.0591051947785544 down FEEYEWCGQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FEEYEWCGQKR 11 1 Q5TDE7;Q5TDE8;Q5VTB9-3;Q5VTB9;H0Y7B1 Q5TDE7 RNF220 E3 ubiquitin-protein ligase RNF220 1 19097600.0 7870100.0 7940600.0 3286900.0 True False 10779888.651455503 7589758.035947264 2510601.9158304073 1.0 0.7040664594362478 0.2328968319623065 23.361838940370358 -7.187553224682583 0.4252283671684943 1.02290080709196 2.925907568124866e-11 0.9996108048583482 0.006231698264992105 0.08658702889824145 0.0272205182854835 0.008932133569037288 0.044134497217815184 6.49302051902024e-08 7.187553224682583 -1.022900807062701 down FEEYEWCGQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FEEYEWCGQKR 11 1 Q5TDE7;Q5TDE8;Q5VTB9-3;Q5VTB9;H0Y7B1 Q5TDE7 RNF220 E3 ubiquitin-protein ligase RNF220 1 11035800.0 5439600.0 2477600.0 3118600.0 True False 4523268.41513906 2464252.6770349047 3770684.841222784 1.0 0.5447947039329405 0.8336195191518081 22.108934178758048 -10.411572799148065 6.381487076673178 1.0000546299112465 0.6892071115423748 0.6068987799596842 0.11791223705664387 9.166183176442268e-05 8.452246668661847e-06 0.11418802541030312 0.038056010869536874 3.8763876463810805e-11 10.411572799148065 -0.3108475183688717 FEGGVVIAADMLGSYGSLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FEGGVVIAADMLGSYGSLAR 20 0 P28070 P28070 PSMB4 Proteasome subunit beta type-4 0 35503100.0 5865100.0 17512000.0 12126000.0 False True 8897785.496244976 14386846.778119514 9729290.784985395 1.0 1.6169019565813336 1.0934508130243563 23.085014888422972 -10.170078550597008 4.438201257844867 0.9999335835302313 1.355176384811329 0.3803704202129595 0.2136980345730156 23962007.57296422 54908637.525955684 10304.903257513577 0.07315452215254457 6.759607037050157e-11 10.170078550597008 0.35524280128109764 FEGGVVIAADMLGSYGSLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FEGGVVIAADMLGSYGSLAR 20 0 P28070 P28070 PSMB4 Proteasome subunit beta type-4 0 18684700.0 5865100.0 5703200.0 7116400.0 False True 7592487.568405237 5385811.906484281 5821288.22043023 1.0 0.7093606486622859 0.7667168589981586 22.85614121051542 -10.711885805203535 6.801353856865901 1.0028752158745478 0.7380387538302234 0.9652937580835473 0.023415574817105773 0.0010299943759234287 4.3631851731808756e-05 0.02287456329361295 0.007557344275710369 1.9413962875076907e-11 10.711885805203535 -0.2648364620443243 FEGK(ub)PLLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FEGKPLLQR 9 1 A0A087WZT3;Q9H3K6;H3BV85;H3BTW0;A0A0B4J295;Q9H3K6-2;H3BVE0 A0A087WZT3;H3BVE0 BOLA2;BOLA2B BolA-like protein 2 1 9045200.0 2554200.0 2923100.0 3567900.0 True False 3348580.9349079877 2486984.874154556 3198727.933713486 1.0 0.7426981525900892 0.9552488041628836 21.675118407608462 -10.021831155439033 6.1452775917886955 1.0000001472090456 0.8489734786038698 0.4023296308346792 0.08677344014159671 1.7495624103585064e-07 2.7910811736713477e-08 0.0840181035178659 0.028006007380124112 9.509744406588301e-11 10.021831155439033 -0.15102666860517577 FEGK(ub)PLLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEGKPLLQR 9 1 A0A087WZT3;Q9H3K6;H3BV85;H3BTW0;A0A0B4J295;Q9H3K6-2;H3BVE0 A0A087WZT3;H3BVE0 BOLA2;BOLA2B BolA-like protein 2 1 17052200.0 4162800.0 4121500.0 8767900.0 True False 4030654.192601516 5767236.443338564 6471323.9586382 1.0 1.4308437707021948 1.6055269565215158 21.942582582724167 -11.59140251103398 0.15878806487043243 2.293523594916566e-13 1.8068081273363232 0.9995690485174128 0.005282673118889269 4.4173636424397245 0.10080278811721276 1.6691518533665597 0.15423602317608842 2.562108333010389e-12 11.59140251103398 1.8068081273360939 FEGK(ub)PLLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FEGKPLLQR 9 1 A0A087WZT3;Q9H3K6;H3BV85;H3BTW0;A0A0B4J295;Q9H3K6-2;H3BVE0 A0A087WZT3;H3BVE0 BOLA2;BOLA2B BolA-like protein 2 1 42386900.0 5973400.0 7871500.0 28542000.0 True False 9062084.514035525 6466769.324689787 22900661.189597003 1.0 0.7136072627301074 2.5270853691695363 23.111411514976997 -6.866501544945022 1.1523685741885836 0.8409786438066384 2.626494801125818 0.9610690768523424 0.15706046094996584 0.1402574195427098 0.3502956803293861 0.10597965317862912 0.2495094136516964 1.359873325706909e-07 6.866501544945022 1.7855161573191793 up FEGK(ub)PLLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FEGKPLLQR 9 1 A0A087WZT3;Q9H3K6;H3BV85;H3BTW0;A0A0B4J295;Q9H3K6-2;H3BVE0 A0A087WZT3;H3BVE0 BOLA2;BOLA2B BolA-like protein 2 1 10314100.0 2554200.0 2331100.0 5428800.0 True False 3498556.7646596204 2228104.2940831496 4146629.2496455996 1.0 0.636863839566692 1.1852399513800747 21.738328469131353 -6.728150242140942 1.7299324350545355 0.7810158235974514 1.184806815677328 0.5506641129611702 0.1526776046113216 0.3397287973785046 1.9909282422139858 0.06996363523791711 0.17397757075208348 1.870035098572212e-07 6.728150242140942 0.40379099207987657 FEGK(ub)PLLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FEGKPLLQR 9 1 A0A087WZT3;Q9H3K6;H3BV85;H3BTW0;A0A0B4J295;Q9H3K6-2;H3BVE0 A0A087WZT3;H3BVE0 BOLA2;BOLA2B BolA-like protein 2 1 16115700.0 4162800.0 6901600.0 5051300.0 True False 3461552.643308489 6864419.710939665 6107503.475427647 1.0 1.9830464587066854 1.7643826643035554 21.722987858158444 -10.101269015102377 5.477344677585584 0.999989561278752 1.8737145615054325 0.9551317471907289 0.08926912025252337 1.13812140887368e-05 1.867571290070917e-06 0.08643548544568593 0.028811484672224198 7.920105832584556e-11 10.101269015102377 0.8737250002266804 FEGK(ub)TFYVIGTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FEGKTFYVIGTQK 13 1 A2A2Y4-5;A2A2Y4-2;A2A2Y4;Q5JV61;A2A2Y4-3 A2A2Y4-5 FRMD3 FERM domain-containing protein 3 1 14035300.0 4873700.0 5413200.0 3748400.0 True False 6389467.896977945 4605571.660488336 3360551.52519174 1.0 0.7208067611806382 0.5259517035497111 22.60726436053478 -7.821690795526149 0.12249282587406382 1.407884918488203 3.606708711284469e-11 0.9999846165022154 0.0007630291638578885 0.12858668220467623 0.016857764551719258 0.07901085547015031 0.10227697936741391 1.5076801065761043e-08 7.821690795526149 -1.4078849184521358 FEGK(ub)TFYVIGTQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEGKTFYVIGTQK 13 1 A2A2Y4-5;A2A2Y4-2;A2A2Y4;Q5JV61;A2A2Y4-3 A2A2Y4-5 FRMD3 FERM domain-containing protein 3 1 10927900.0 2872100.0 3641600.0 4414200.0 True False 2780926.7576080533 5095709.87069312 3257988.596838553 1.0 1.8323783094079298 1.1715477899320272 21.407134317666767 -10.109026142495486 4.50032858575493 0.9999549310266982 1.501963049502078 0.4348082999876455 0.2697829299384912 187960060.19536084 7.790763806713992 95613.61713465645 0.09235387271177024 7.779897182899024e-11 10.109026142495486 0.5020081184753797 FEGK(ub)TFYVIGTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FEGKTFYVIGTQK 13 1 A2A2Y4-5;A2A2Y4-2;A2A2Y4;Q5JV61;A2A2Y4-3 A2A2Y4-5 FRMD3 FERM domain-containing protein 3 1 9493500.0 4873700.0 2823000.0 1796800.0 True False 6675638.596790227 2698270.525587376 1372432.846257591 1.0 0.40419661526984935 0.2055882484287694 22.670474422057673 -13.999999999999998 0.15455815342014 3.9069576679153655 3.093659950615048e-17 0.9995534838510016 0.007132940769576906 11.966422482389412 0.12391323710783429 10.434967189803233 0.1865598122697764 1.0000000000000041e-14 13.999999999999998 -3.9069576679153655 FEGLK(ub)EFLQQTDDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEGLKEFLQQTDDR 14 1 Q6Q0C0;Q6Q0C0-2 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 4559300.0 2182000.0 2377300.0 0.0 True False 2112733.6043664156 3326568.287455722 0.0 1.0 1.5745327667343663 0.0 21.0106794379276 -6.825098190815395 1.464812690999366 1.3127331380967753 2.189277134686049e-21 0.8538205970113047 0.24873739470578987 0.2000515618766774 0.8602752518306317 0.1357091015870459 0.29597540929925314 1.4958974063627833e-07 6.825098190815395 -1.3127331380967753 down FEGLK(ub)EFLQQTDDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FEGLKEFLQQTDDR 14 1 Q6Q0C0;Q6Q0C0-2 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 7750400.0 2182000.0 1099900.0 4468500.0 True False 1814429.6789898938 1093974.6203869442 5402842.689990383 1.0 0.6029302943258555 2.9777085067293347 20.791084713361876 -6.863912271777228 1.1657154118353439 0.7818658183570039 3.1016564487117964 0.9582261933354971 0.21227963584821688 0.14283112498145623 0.36660226817981106 0.14178075906503218 0.3325781269916024 1.3680051370477595e-07 6.863912271777228 2.3197906303547926 up FEHSAK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FEHSAKLR 8 1 Q9UPT9;Q9UPT9-2 Q9UPT9 USP22 Ubiquitin carboxyl-terminal hydrolase 22 1 42370000.0 13640100.0 20878700.0 7851200.0 True False 17882303.19091629 17763679.344535176 7038833.138028329 1.0 0.9933664111879408 0.39362005346178564 24.092029227808837 -6.909315375125398 0.9003644227625349 1.0189741513252515 0.3172321908848215 0.9906610101749265 0.027474271315158814 0.10487330554356605 0.14122865648698063 0.022417629194077807 0.06159473271664425 1.2322097046010495e-07 6.909315375125398 -0.70174196044043 down FEHSAK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEHSAKLR 8 1 Q9UPT9;Q9UPT9-2 Q9UPT9 USP22 Ubiquitin carboxyl-terminal hydrolase 22 1 51321900.0 16646800.0 23556300.0 11118800.0 True False 16118356.445997614 32962453.43448164 8206452.723149936 1.0 2.045025716171367 0.5091370668370905 23.94220130707897 -6.7235102028661915 1.7468455894345227 1.63338749027908 0.5110702080706203 0.5289773425556248 0.4395712319159191 0.34853099763452766 2.0803361328962486 0.19966756781649128 0.4991522906438347 1.890121826094481e-07 6.7235102028661915 -1.1223172822084595 FEHSAK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FEHSAKLR 8 1 Q9UPT9;Q9UPT9-2 Q9UPT9 USP22 Ubiquitin carboxyl-terminal hydrolase 22 1 37716400.0 13640100.0 14721400.0 9354900.0 True False 18683213.579842463 14070959.870840233 7145465.290213237 1.0 0.7531338123769861 0.3824537604131744 24.15523928933173 -6.965240110425455 0.35390680416075343 1.0342493270695008 0.08875473696728488 0.9999180098569036 0.0022980717450801456 0.07787957221429435 0.014573144539006069 0.005039849171866524 0.03178013681195555 1.0833278039002854e-07 6.965240110425455 -0.9454945901022159 down FEHSAK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FEHSAKLR 8 1 Q9UPT9;Q9UPT9-2 Q9UPT9 USP22 Ubiquitin carboxyl-terminal hydrolase 22 1 42520980.0 16646800.0 25208900.0 665280.0 True False 13842551.778280897 25073094.65212515 804386.9720928291 1.0 1.811305823790747 0.05810973185991042 23.722606582513247 -6.780849653465484 1.5324087969172606 1.458858818991291 0.04380129945589179 0.770473792023078 0.3432196964282817 0.24923336421691555 1.156047712155878 0.1763928472769731 0.41594479460447514 1.6563432665643587e-07 6.780849653465484 -1.4150575195353992 FEIPYFTTSGIQVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FEIPYFTTSGIQVR 14 0 E7ENJ6;Q9BXS5;Q9BXS5-2;K7EJL1 E7ENJ6 AP1M1 AP-1 complex subunit mu-1 0 2985100.0 920970.0 881530.0 1182600.0 False True 1207400.5886861677 750009.1601770269 1060235.8963002232 1.0 0.6211767388594277 0.8781144437356274 20.20347297899511 -10.021116204202688 5.282021649223001 1.0000016907128 0.749645591296911 0.5586709316969802 0.10489437877357437 2.088368334869389e-06 3.8709628368259916e-07 0.10156423106047602 0.03385451517475768 9.525412583963316e-11 10.021116204202688 -0.250356099415889 FEIPYFTTSGIQVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEIPYFTTSGIQVR 14 0 E7ENJ6;Q9BXS5;Q9BXS5-2;K7EJL1 E7ENJ6 AP1M1 AP-1 complex subunit mu-1 0 6123900.0 3222800.0 1429300.0 1471800.0 False True 3120493.978071534 2000026.9437010325 1086291.4269464419 1.0 0.6409328003052419 0.3481152133540633 21.573342996906465 -7.618121986391054 0.2263172749766631 1.1712060521991967 1.814557423679211e-11 0.999879301083854 0.002928817823244884 0.1310954646389939 0.026042533136650108 0.03747899874748369 0.07489214751309517 2.4092286197571653e-08 7.618121986391054 -1.1712060521810512 down FEIPYFTTSGIQVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FEIPYFTTSGIQVR 14 0 E7ENJ6;Q9BXS5;Q9BXS5-2;K7EJL1 E7ENJ6 AP1M1 AP-1 complex subunit mu-1 0 4415070.0 920970.0 1069900.0 2424200.0 False True 1261477.497278432 1022628.2803138285 1851653.887966189 1.0 0.8106591536671027 1.467845357496293 20.266683040518 -6.8296674608346235 1.329511375208259 0.8988076707612468 1.4853954814068693 0.9051866380824719 0.085049677735454 0.1812222036116441 0.6266153576759926 0.050230522254846095 0.11558915360791963 1.4802413747627278e-07 6.8296674608346235 0.5865878106456225 FEIPYFTTSGIQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FEIPYFTTSGIQVR 14 0 E7ENJ6;Q9BXS5;Q9BXS5-2;K7EJL1 E7ENJ6 AP1M1 AP-1 complex subunit mu-1 0 7187000.0 3222800.0 1594000.0 2370200.0 False True 2679900.994247769 1585412.805615773 2865797.861433411 1.0 0.5915937973151834 1.0693670652701937 21.35374827234074 -6.680346185730125 1.9004945746446256 0.7416792475830345 1.0675604757227057 0.3257728230264806 0.1730787867867889 0.43775957966484264 3.057224994305359 0.07306503516692707 0.19263019987490437 2.087631370328218e-07 6.680346185730125 0.32588122813967124 FEIVYNLLSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FEIVYNLLSLR 11 0 O75489 O75489 NDUFS3 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial 0 7870300.0 0.0 3648800.0 4221500.0 False True 0.0 3445741.0724470187 3453230.3162478474 0.0 FEK(ub)EAAEMGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FEKEAAEMGK 10 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 30603200.0 10119000.0 13552000.0 6932200.0 True False 13266106.992535403 11530094.425282268 6214922.442357858 1.0 0.8691392608072619 0.4684812542108157 23.661241730732243 -6.950992367865082 0.5478452686079006 1.0056130782243013 0.3132546901564553 0.9992768470907949 0.006080646063805546 0.08308978031914231 0.03433266695309905 0.006618211763146663 0.033224653424852285 1.1194575562384797e-07 6.950992367865082 -0.6923583880678461 down FEK(ub)EAAEMGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 FEKEAAEMGK 10 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 33664300.0 11856600.0 12647100.0 9160600.0 True False 11480218.72297471 17697152.983755235 6761164.047890717 1.0 1.5415344786366245 0.5889403513157797 23.45264679294508 -6.752490957467442 1.6406097463518123 1.3174685068754544 0.5866784173140704 0.6596437421761707 0.22758981645218604 0.2957114516565857 1.5667346976960848 0.10955057838505385 0.2652690727262101 1.7681090315040174e-07 6.752490957467442 -0.7307900895613839 FEK(ub)EAAEMGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FEKEAAEMGK 10 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 59537000.0 17707000.0 17865000.0 23965000.0 True False 26862813.555098746 14676851.170117911 19228307.245767362 1.0 0.5463631402575901 0.7157964747932257 24.67910708176207 -10.23671310601769 4.985324955039565 1.0000577694629933 0.6310798075251028 0.8634120912618268 0.06917086917282961 4.442066007472165e-05 6.801271971609377e-06 0.06698486301459369 0.022324802028936178 5.798115922091488e-11 10.23671310601769 -0.36897796193789045 FEK(ub)EAAEMGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FEKEAAEMGK 10 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 37152900.0 14200700.0 12076700.0 10875500.0 True False 19451082.54948784 11543111.46169363 8306930.887953263 1.0 0.5934431377958225 0.42706779259296235 24.21334711481201 -13.999999999999998 0.12285564006274537 2.934361366691342 0.17145957896595967 0.9996790525400061 0.004311278649609487 11.953701611376005 0.10822981498418481 5.625319367032438 0.22689400943046062 1.0000000000000041e-14 13.999999999999998 -2.7629017877253825 FEK(ub)EAAEMGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FEKEAAEMGK 10 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 38030700.0 11856600.0 19503400.0 6670700.0 True False 9859288.236439757 19398331.3130782 8065512.528168036 1.0 1.9675184301217916 0.8180623524483281 23.233052068379358 -6.683514439042612 1.8893068835497566 1.6102200832417128 0.8223037684267046 0.34028924305209596 0.4097464733543437 0.43078299451236013 2.9758530145997106 0.1738288984130369 0.4564239196097224 2.072457155196551e-07 6.683514439042612 -0.7879163148150082 FEK(ub)EAAEMGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FEKEAAEMGK 10 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 57399000.0 17707000.0 15219000.0 24473000.0 True False 22922060.55715187 14372049.271423811 20019165.1141854 1.0 0.6269963922130734 0.873358006548816 24.45023340385452 -10.700743439902446 5.142301905490555 1.0072237796821955 0.7501771993809834 0.5782478930041983 0.10057670788848583 0.008508315404740396 0.0004951415235694383 0.09947305039911589 0.032460992889039274 1.9918496795890333e-11 10.700743439902446 -0.2570465803012121 FEK(ub)EQQQLNWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FEKEQQQLNWK 11 1 P26010;P26010-2;H3BRX4 P26010 ITGB7 Integrin beta-7 1 83809500.0 9879700.0 14870400.0 59059400.0 True False 12952382.375150913 12651794.284365196 52948499.82576809 1.0 0.976792833775322 4.087935199268788 23.626714146270327 -6.9052199407431205 0.9276887407548715 0.8885152562073035 4.451434911028099 0.9889888553210562 0.15332613271032125 0.10766392817273676 0.15654748613157068 0.12263586352683756 0.3282969555789544 1.243884508969134e-07 6.9052199407431205 3.5629196548207958 up FEK(ub)EQQQLNWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEKEQQQLNWK 11 1 P26010;P26010-2;H3BRX4 P26010 ITGB7 Integrin beta-7 1 191518300.0 8439200.0 10252100.0 172827000.0 True False 8171302.215384538 14345816.993995206 127558424.00113636 1.0 1.7556341224273393 15.610538031621868 22.96213458037206 -6.918162041060449 0.8382621819424362 0.6735599204568768 17.752842504397698 0.9936543551551184 0.5350299917299778 0.09926603102797175 0.11131368061883788 0.4565469568765851 1.3444106289871802 1.2073632677260254e-07 6.918162041060449 17.07928258394082 up FEK(ub)EQQQLNWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FEKEQQQLNWK 11 1 P26010;P26010-2;H3BRX4 P26010 ITGB7 Integrin beta-7 1 768596900.0 18606900.0 207912000.0 542078000.0 True False 28228027.64660114 170808479.17612943 434936045.69877255 1.0 6.051024227216811 15.407950252278502 24.750624992295073 -6.961515243917361 0.41352524792313733 0.556417045457081 21.25180408064538 0.9998223332186895 0.07956098519458596 0.07916421942905771 0.01916367538831419 0.12063165437037572 0.7803653639581184 1.0926592737197922e-07 6.961515243917361 20.695387035188297 FEK(ub)EQQQLNWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FEKEQQQLNWK 11 1 P26010;P26010-2;H3BRX4 P26010 ITGB7 Integrin beta-7 1 102587500.0 9879700.0 9448900.0 83258900.0 True False 13532492.078853521 9031416.354666157 63594862.59087047 1.0 0.6673875219760189 4.699419901397663 23.68992420779322 -6.8868918665353815 1.040625407264867 0.7669366854231006 5.025769115472682 0.978831991872464 0.26586867101817274 0.12169988080898651 0.2368849931081394 0.1954243845852248 0.48203763637540264 1.2975022913274742e-07 6.8868918665353815 4.258832430049581 up FEK(ub)EQQQLNWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FEKEQQQLNWK 11 1 P26010;P26010-2;H3BRX4 P26010 ITGB7 Integrin beta-7 1 130296200.0 8439200.0 14200000.0 107657000.0 True False 7017568.719950283 14123501.781520681 130167580.95027298 1.0 2.0125918740729825 18.5488145745148 22.742539855806335 -6.9194213107516855 0.8290054467676733 0.6274706860940094 21.180271985175246 0.9940186728889131 0.6221576857788363 0.09851360101619556 0.10738692466623882 0.5344157068715918 1.59208418025642 1.2038674972062492e-07 6.9194213107516855 20.552801299081235 up FEK(ub)EQQQLNWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FEKEQQQLNWK 11 1 P26010;P26010-2;H3BRX4 P26010 ITGB7 Integrin beta-7 1 223869900.0 18606900.0 147311000.0 57952000.0 True False 24086998.846832816 139113013.3532237 47405330.63773432 1.0 5.77543986437794 1.9680878858832018 24.521751314387522 -6.589544925778786 2.230088367767056 4.232893006881796 1.9789173415610561 0.0 2.069560540718279 0.6708396568866615 6.288766455190389 0.7748226063943976 2.307676652328179 2.5730905762010836e-07 6.589544925778786 -2.2539756653207403 FEK(ub)NFYQEHPDLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEKNFYQEHPDLAR 14 1 J3KTA4;P17844;P17844-2;J3QRQ7;J3QR02;J3KRX8;J3KTQ4;X6RLV5 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 8335800.0 1738700.0 2431400.0 4165700.0 True False 1683505.9202162616 3402270.6995834946 3074578.201678756 1.0 2.0209437096285603 1.8262948557280978 20.68303736387947 -10.22182375056733 4.810716703538353 0.9998333107817633 1.9236192826805723 0.9677634755601495 0.07946506185333964 0.0001420928362377801 2.2984788080031916e-05 0.07695533307090963 0.025647238429178872 6.00034538456626e-11 10.22182375056733 0.923785971898809 FEK(ub)NFYQEHPDLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FEKNFYQEHPDLAR 14 1 J3KTA4;P17844;P17844-2;J3QRQ7;J3QR02;J3KRX8;J3KTQ4;X6RLV5 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 30966900.0 4230600.0 4183200.0 22553100.0 True False 6418129.498288857 3436675.276509218 18095469.899625108 1.0 0.535463685708659 2.8194304749459413 22.613721468425716 -6.853738224360438 1.2169153108057071 0.7510766621310025 2.917540357357741 0.9455755091640908 0.2299306521097737 0.15338685991634685 0.43523394674062005 0.14769662832351269 0.3426980093235045 1.4004311930868357e-07 6.853738224360438 2.1664636952267387 up FEK(ub)NFYQEHPDLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FEKNFYQEHPDLAR 14 1 J3KTA4;P17844;P17844-2;J3QRQ7;J3QR02;J3KRX8;J3KTQ4;X6RLV5 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 6885300.0 1738700.0 1883500.0 3263100.0 True False 1445806.0874700847 1873353.2116545208 3945399.123130271 1.0 1.295715399104849 2.7288577336356705 20.463442639313747 -6.940503760750605 0.6548590913979341 0.9840424404596021 3.1211274938456577 0.9982291551672859 0.03177167437385271 0.08753754001394339 0.05356848555461273 0.03104670272504576 0.12307645227944591 1.1468225905285685e-07 6.940503760750605 2.1370850533860555 up FEK(ub)NFYQEHPDLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FEKNFYQEHPDLAR 14 1 J3KTA4;P17844;P17844-2;J3QRQ7;J3QR02;J3KRX8;J3KTQ4;X6RLV5 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 33765600.0 4230600.0 3898100.0 25636900.0 True False 5476595.097593422 3681167.3082947116 20971247.25680787 1.0 0.6721634962409994 3.8292491745506725 22.384847790518165 -6.881265591945505 1.0726706988512145 0.7931809651861542 4.058532511771339 0.974693923206036 0.22546657806436046 0.12651695453608666 0.2655375008442846 0.161721595619036 0.39238737922489697 1.3144207548958425e-07 6.881265591945505 3.2653515465851846 up FELALQLGELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FELALQLGELK 11 0 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 0 152020000.0 51158000.0 66443000.0 34419000.0 False True 77610426.15077332 54585727.528471515 27616069.563616406 1.0 0.7033298261038813 0.35582937671243847 26.209747140665428 -7.035448154847322 0.28929484185904386 1.0712722593148611 1.6908794384519106e-13 0.9999711662754778 0.0014135860854396845 0.07255141837789472 0.01063859871270274 0.006328389372830662 0.03030297432372918 9.216199031944267e-08 7.035448154847322 -1.071272259314692 down FELALQLGELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FELALQLGELK 11 0 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 0 106750000.0 51158000.0 38889000.0 16703000.0 False True 66225039.474940784 36724792.963821545 13663225.38725283 1.0 0.5545454295684945 0.20631509615668744 25.980873462757877 -7.964741416540557 0.3096647652090991 1.1136753333183271 5.66618719598824e-22 0.9991199780749296 0.009636128793123807 0.10246807727534682 0.058428000512992 0.05405661003570608 0.08817641638020607 1.0845724875707926e-08 7.964741416540557 -1.1136753333183271 down FELAVDAVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FELAVDAVHR 10 0 Q8WWM7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7-3;H3BUF6;Q8WWM7-7;H3BSK9;H3BSQ5;H3BUE3 Q8WWM7 ATXN2L Ataxin-2-like protein 0 4335500.0 1427000.0 1356600.0 1551900.0 False True 1870810.819087659 1154200.5679853838 1391324.2748759647 1.0 0.6169520489240352 0.7437012126936885 20.835232246468724 -10.916271230559877 11.119372110548246 1.0374709854313386 0.6803266308088618 0.8945290176761979 0.05174512942668516 0.027979685585978464 0.00021068641139894938 0.029164265591688575 0.01670066870974158 1.2126312875596898e-11 10.916271230559877 -0.35714435462247685 FELAVDAVHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FELAVDAVHR 10 0 Q8WWM7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7-3;H3BUF6;Q8WWM7-7;H3BSK9;H3BSQ5;H3BUE3 Q8WWM7 ATXN2L Ataxin-2-like protein 0 3818360.0 942500.0 882160.0 1993700.0 False True 912580.853398417 1234411.0884036259 1471490.1602820493 1.0 1.3526594205945972 1.6124490830618186 19.79959285976002 -6.974470336113497 0.1066683328131566 0.42425494489528287 2.5474697206023174 0.9999996649304247 0.00014516992843515052 0.07487702398530616 0.0031453241683193247 0.02150615647908582 0.04064910768846264 1.0605463750580899e-07 6.974470336113497 2.1232147757070345 FELAVDAVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FELAVDAVHR 10 0 Q8WWM7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7-3;H3BUF6;Q8WWM7-7;H3BSK9;H3BSQ5;H3BUE3 Q8WWM7 ATXN2L Ataxin-2-like protein 0 4538800.0 1427000.0 2049100.0 1062700.0 False True 1954600.4632249936 1958563.9865324474 811712.1469935112 1.0 1.0020277920639158 0.4152828991221186 20.898442307991616 -6.906121119842991 0.9217482283591696 1.020469641639401 0.3454262247474144 0.9893735322610661 0.028463503665295473 0.10703916380209319 0.1530956879786747 0.022865447927284836 0.061544700793202095 1.2413060730214046e-07 6.906121119842991 -0.6750434168919865 down FELFVMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 FELFVMK 7 0 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 0 21492700.0 7226400.0 6731330.0 7534970.0 False True 9473880.380557157 5727041.802518837 6755323.584935976 1.0 0.6045085616947626 0.7130471690142552 23.175524025551432 -10.214194467950353 7.897011952555276 1.0000002125795666 0.6587778653545109 0.9294674546551667 0.044310700887511385 1.658657313866861e-07 1.6515141039027547e-08 0.04290367849958957 0.014301217216342484 6.10668519134075e-11 10.214194467950353 -0.34122234722505573 FELFVMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FELFVMK 7 0 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 0 14458500.0 5152100.0 2814400.0 6492000.0 False True 4988549.405616954 3938204.5969021083 4791550.444174675 1.0 0.789448851096435 0.9605097703912757 22.25018893206798 -9.99318965241027 5.606890932127681 1.0000002830779275 0.8749793108012632 0.4159554862942011 0.06983532786763622 2.47077650971797e-07 4.4297345783198655e-08 0.06761791810017093 0.022539255150641292 1.0158050032876932e-10 9.99318965241027 -0.1250209722766643 FELFVMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FELFVMK 7 0 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 0 19056800.0 3461900.0 10521000.0 5073900.0 False True 5251955.398791236 8643445.34905181 4071041.441030627 1.0 1.6457575688935102 0.7751477558182611 22.32442323380023 -6.708065516062163 1.8021878221678556 1.3977824927978038 0.7773154742784899 0.4558658269126531 0.2722027112307281 0.37897924026001906 2.398187674601963 0.1202539212020708 0.3062102794141239 1.9585491917186317e-07 6.708065516062163 -0.6204670185193139 FELFVMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FELFVMK 7 0 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 0 25345610.0 7226400.0 8446410.0 9672800.0 False True 9898195.366117097 8073219.677657269 7388283.857569237 1.0 0.8156254124153808 0.7464273621897142 23.238734087074324 -13.999999999999998 0.1360012627871121 1.8781200600805668 0.6565206491041309 0.9996193439133284 0.002088015490210456 11.932021451893734 0.11523385222109057 2.7875755085769143 0.08017888119907764 1.0000000000000041e-14 13.999999999999998 -1.2215994109764359 FELFVMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FELFVMK 7 0 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 0 11399500.0 5152100.0 3098800.0 3148600.0 False True 4284199.426729523 3082106.149336356 3806957.702518456 1.0 0.7194123901204987 0.8886042229422116 22.030594207502258 -10.294817807824103 5.457884881558942 1.0000277608866173 0.8040083069306229 0.6414723433998776 0.06907227650993589 2.333594832194427e-05 3.0151058953801234e-06 0.06688840846623834 0.02229298138396451 5.0720344208094084e-11 10.294817807824103 -0.1960194539559944 FELFVMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FELFVMK 7 0 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 0 17289100.0 3461900.0 6368800.0 7458400.0 False True 4481497.794251093 6014370.681374859 6101047.729646561 1.0 1.342044771078578 1.3613858602079514 22.095549555892678 -11.987672186152146 0.44748564851590206 3.1602857068960666e-11 1.3614787675017026 0.9998285883392435 0.0021731795114265868 5.928216957114125 0.22394475213298135 5.611960431138806 0.004389791148199922 1.0287925575787247e-12 11.987672186152146 1.3614787674700997 FELGSSSIAHMVMGTTNQFSTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FELGSSSIAHMVMGTTNQFSTR 22 0 Q9NZ08;Q9NZ08-2;H0Y9X5 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 7095100.0 2830700.0 2023000.0 2241400.0 False True 2740840.97794684 2830794.449805631 1654310.0994413318 1.0 1.0328196610392824 0.6035775562143605 21.386187195560545 -6.888452979113739 1.0315231224911923 1.0239264157727785 0.5677629860381309 0.9798883075585328 0.027664227069437393 0.12040599011904457 0.229267640754631 0.020475361734984713 0.050767715801765194 1.2928466692105536e-07 6.888452979113739 -0.45616342973464763 FELLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FELLAR 6 0 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 0 2636520.0 1429000.0 389300.0 818220.0 False True 1383637.1771950528 544749.5201726806 603903.6359261556 1.0 0.3937083573289146 0.4364609782677317 20.400034252699808 -9.978613865056206 6.185683304003805 1.000000281268975 0.4150846677982846 0.9960091617913859 0.017453684411259333 6.768334917385679e-08 1.1195366006394759e-08 0.016899465321643662 0.005633152421210399 1.0504760007774426e-10 9.978613865056206 -0.5849156134706903 FELSCYSLAPQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FELSCYSLAPQIK 13 0 P00966;Q5T6L6 P00966 ASS1 Argininosuccinate synthase 0 71559000.0 13718000.0 27646000.0 30195000.0 False True 17984430.845300984 23521324.563263964 27070711.05089227 1.0 1.3078715009438107 1.5052303452775306 24.100245167323717 -9.246219757773195 0.07575851465102128 2.3134648781771754e-15 2.358256856531649 0.9999846822258052 0.0008136480341310126 0.7108971289476761 0.027313218683445682 0.4887251011199088 0.3489376862257638 5.672574942575765e-10 9.246219757773195 2.358256856531647 FELSCYSLAPQIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FELSCYSLAPQIK 13 0 P00966;Q5T6L6 P00966 ASS1 Argininosuccinate synthase 0 26085700.0 13954000.0 4682500.0 7449200.0 False True 13511037.908033442 6552246.668914918 5498031.048790206 1.0 0.48495509475397586 0.4069288448610722 23.68763516990824 -13.999999999999998 0.26570992381698627 4.885317727969487 0.37993284991122617 0.9995741895235778 0.005429539767638701 14.677186964578773 0.16314547358381265 30.724837048248677 0.033116115047923174 1.0000000000000041e-14 13.999999999999998 -4.505384878058261 FELSCYSLAPQIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FELSCYSLAPQIK 13 0 P00966;Q5T6L6 P00966 ASS1 Argininosuccinate synthase 0 77417600.0 6285400.0 65806000.0 5326200.0 False True 9535411.324290833 54062405.15537523 4273474.235443611 1.0 5.669645840830674 0.4481688403474758 23.18486374202219 -6.670947318485198 1.934152779871756 3.978285309375698 0.4693212579252414 0.28310216324391513 1.9831530737217398 0.4590076119982681 3.311396937446005 0.8252090244406953 2.201921031282561 2.133303675018287e-07 6.670947318485198 -3.5089640514504565 FELSCYSLAPQIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FELSCYSLAPQIK 13 0 P00966;Q5T6L6 P00966 ASS1 Argininosuccinate synthase 0 65520000.0 13718000.0 26131000.0 25671000.0 False True 18789915.31501083 24976446.01633857 19608038.5108407 1.0 1.3292473966812113 1.0435405472624077 24.16345522884661 -9.990912166642365 7.877713665336665 0.9999999979052773 1.1863939719718095 0.36203896326179896 0.11663933284904288 4.211004093193155e-09 6.408728430120104e-10 0.11293555093357785 0.03764518280309058 1.0211459832488922e-10 9.990912166642365 0.18639397406653224 FELSCYSLAPQIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FELSCYSLAPQIK 13 0 P00966;Q5T6L6 P00966 ASS1 Argininosuccinate synthase 0 25619600.0 13954000.0 2169300.0 9496300.0 False True 11603369.267014198 2157613.5503276642 11481932.424069751 1.0 0.18594715902572198 0.989534346434215 23.468040445342517 -10.92796832955721 12.494144925180768 1.0519034559615132 0.5877407532544187 0.2597661165201801 0.3280630954981812 0.16546147732739364 0.000953922287501652 0.1108096545639685 0.10588190878080911 1.180406712361774e-11 10.92796832955721 -0.4641627027070946 FELSCYSLAPQIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FELSCYSLAPQIK 13 0 P00966;Q5T6L6 P00966 ASS1 Argininosuccinate synthase 0 21475200.0 6285400.0 9623600.0 5566200.0 False True 8136574.203756845 9088038.200175706 4553208.714035007 1.0 1.1169366827601166 0.5595977619097587 22.95599006411464 -6.851924785686023 1.2258274111658003 1.0625160254201758 0.5364833069433681 0.9430573073949049 0.05726239255035862 0.15534671483381382 0.4482442300114881 0.036535304811942636 0.08465225902430054 1.4062910548736552e-07 6.851924785686023 -0.5260327184768077 FELYFQGPSSNK(ub)PR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FELYFQGPSSNKPR 14 1 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 52590000.0 18032000.0 18434000.0 16124000.0 True False 23640126.622136403 15683719.055169214 14455643.152329437 1.0 0.6634363388089097 0.6114875517964994 24.49473442716518 -13.999999999999998 0.2630458307183665 3.503430091377325 0.5930473185863308 0.9995686090067545 0.003576850379479184 14.553944324141842 0.16231200734388132 19.40283334917238 0.022352753487816023 1.0000000000000041e-14 13.999999999999998 -2.910382772790994 FELYFQGPSSNK(ub)PR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FELYFQGPSSNKPR 14 1 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 69279000.0 18074000.0 24373000.0 26832000.0 True False 17500250.763207406 34105266.00351587 19803894.257254317 1.0 1.948844417430801 1.1316348848491988 24.060872258968786 -10.210060616399378 4.289625409049211 0.9997943202416406 1.5402396511591006 0.3681682030336204 0.3336243948146658 234762056.47165045 205.6613847687674 512027.2287870183 0.11420850420474027 6.165089469788727e-11 10.210060616399378 0.5404453309174599 FELYFQGPSSNK(ub)PR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FELYFQGPSSNKPR 14 1 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 118488000.0 40997000.0 19000000.0 58491000.0 True False 62195446.28216992 15609301.552322427 46930228.212483935 1.0 0.25097177503165974 0.7545605187809032 25.89030561970203 -9.881654943061868 6.06031507620312 1.0000000829922064 0.5027661469096959 0.5651974356023757 0.20558924373327483 2.3023532595011242e-07 4.307187230444055e-08 0.19906096191259123 0.06635364309474504 1.3132428862534646e-10 9.881654943061868 -0.49723393608251054 FELYFQGPSSNK(ub)PR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FELYFQGPSSNKPR 14 1 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 58302000.0 18032000.0 22144000.0 18126000.0 True False 24698917.696477268 21165604.85958443 13845012.116688037 1.0 0.8569446288977761 0.5605513685590648 24.557944488688072 -6.959348376529983 0.44452220756822397 1.010111704151984 0.3957411507608466 0.9997452617455737 0.002920904974414728 0.07993471609355372 0.021997630067692425 0.003930817120183689 0.02453804723103859 1.0981246071445824e-07 6.959348376529983 -0.6143705533911374 FELYFQGPSSNK(ub)PR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FELYFQGPSSNKPR 14 1 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 72106000.0 18074000.0 33522000.0 20510000.0 True False 15029331.813961186 33341410.332403988 24798546.1724746 1.0 2.218422664767583 1.6500098926180142 23.841277534403062 -10.1756980537476 5.26502815999473 0.9999572972744775 1.934216278693174 0.7826883819031398 0.23205354250922422 0.00011632807393555358 1.821211362061321e-05 0.22469508370259555 0.07489495879702886 6.672705324459517e-11 10.1756980537476 0.9342589814186966 FELYFQGPSSNK(ub)PR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FELYFQGPSSNKPR 14 1 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 101005000.0 40997000.0 18153000.0 41855000.0 True False 53071424.671686605 17142769.592230514 34237819.46856654 1.0 0.3230131789052219 0.6451271975525518 25.66143194179448 -10.553767047505335 6.441938521737112 1.0006886291092056 0.48407018822922787 0.7737857346056372 0.13150249744721731 0.0013021817409294002 9.020185703369503e-05 0.12748334022610697 0.04244224854981301 2.794042143846408e-11 10.553767047505335 -0.5166184408799778 FELYFQGPSSNKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FELYFQGPSSNKPR 14 1 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 100132000.0 36494000.0 29006000.0 34632000.0 False True 49986818.01326765 27724419.00998496 26452634.868428793 1.0 0.5546346039195026 0.5291922134633106 25.575044357214413 -13.999999999999998 0.40758882550575737 8.88345424333546 0.5279604069072821 0.9998482206992805 0.0026634735033054823 27.922711183269687 0.21132145310063735 195.21767662003592 0.006376916417704123 1.0000000000000041e-14 13.999999999999998 -8.35549383642818 FENAFLSHVVSQHQALLGTIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FENAFLSHVVSQHQALLGTIR 21 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 247471390.0 146969390.0 68907000.0 31595000.0 False True 192678293.54359755 58626344.197382264 28325852.48064056 1.0 0.3042706218701112 0.1470111238774867 27.521618810956173 -13.999999999999998 0.20894676640431042 5.006334633915941 0.053434106269777654 0.9994894475049911 0.008374739480494735 12.722245891752372 0.14489106906463045 20.914178585065606 0.09384494424924124 1.0000000000000041e-14 13.999999999999998 -4.952900527646163 FENAFLSHVVSQHQALLGTIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FENAFLSHVVSQHQALLGTIR 21 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 2198211100.0 864862800.0 582778300.0 750570000.0 False True 837408203.8159627 815484714.3386862 553973200.3826545 1.0 0.9738198295916211 0.6615330466769601 29.641355810860695 -6.923480477353164 0.798490612433746 1.0060649987291785 0.6069093540025537 0.9950943280549959 0.010769149626899146 0.09616702704990895 0.09531856269070833 0.009454038686102739 0.029334367290295857 1.192667878119889e-07 6.923480477353164 -0.3991556447266248 FENAFLSHVVSQHQALLGTIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FENAFLSHVVSQHQALLGTIR 21 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 988500000.0 288970000.0 339010000.0 360520000.0 False True 438388616.5367867 278511016.8027806 289263063.97847056 1.0 0.6353062244247618 0.6598325163267498 28.707635095994174 -10.674561520565808 6.64331575048919 1.0024270742878427 0.647569370375756 0.9963808774800634 0.010012816740404273 0.0003619163155438442 1.7729298957597812e-05 0.00974818996073744 0.003231622707017722 2.115623972469361e-11 10.674561520565808 -0.3548577039120867 FENAFLSHVVSQHQALLGTIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FENAFLSHVVSQHQALLGTIR 21 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 543046390.0 146969390.0 97827000.0 298250000.0 False True 201307945.18142593 93504679.6693718 227809492.65156204 1.0 0.46448578860164724 1.1316468033402853 27.584828872479065 -6.6930345788825 1.8559648238649784 0.665221958654263 1.1294088355578473 0.38455371181082865 0.22634747592447055 0.4101571194659583 2.741609287463468 0.09748676001541227 0.25286456271742963 2.0275212801887682e-07 6.6930345788825 0.4641868769035843 FENAFLSHVVSQHQALLGTIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FENAFLSHVVSQHQALLGTIR 21 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 2240512380.0 864862800.0 563739580.0 811910000.0 False True 719171738.118378 560702602.988995 981676627.1523097 1.0 0.7796504969119094 1.3650100179419487 29.42176108629497 -6.804738024740046 1.4365899160934563 0.879144611633473 1.3740583866082032 0.8456287395337251 0.09484327797156986 0.2140641709535215 0.8716428440430162 0.05192714240293009 0.12042662224879817 1.5676964513109426e-07 6.804738024740046 0.4949137749747302 FENAFLSHVVSQHQALLGTIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FENAFLSHVVSQHQALLGTIR 21 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 1008561800.0 288970000.0 398916000.0 320675800.0 False True 374077361.45028365 376715973.92465353 262316094.81156766 1.0 1.0070536545278765 0.7012348830588897 28.478761418086624 -6.901620368199982 0.9509551398629712 1.0121557083715658 0.6680550285756796 0.9873557018183844 0.016027150250053857 0.11022275341025195 0.17076421762204075 0.012600682768663048 0.03306000765701821 1.254237067814427e-07 6.901620368199982 -0.3441006797958862 FENLCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FENLCK 6 0 P08238;Q58FF7;P07900;P07900-2;Q58FG0;Q58FF8 P08238;Q58FF7;P07900;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA5P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 2 0 48820500.0 1400500.0 27781000.0 19639000.0 False True 1836069.0624612935 23636183.08948982 17606944.670590285 1.0 12.873253829463781 9.58947843006938 20.808188895067467 -9.405782949718803 11.723425352199314 0.9999999990631059 11.231366129766581 0.9282831251038268 1.340595693070053 0.0 0.0 1.2980261983144263 0.432675399438142 3.9284121925110895e-10 9.405782949718803 10.231366130703474 FENLCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FENLCK 6 0 P08238;Q58FF7;P07900;P07900-2;Q58FG0;Q58FF8 P08238;Q58FF7;P07900;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA5P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 2 0 163184100.0 2494800.0 159040000.0 1649300.0 False True 3784793.9943107427 130658069.41480824 1323315.1320861303 1.0 34.52184441510209 0.34963993656598535 21.851783346028046 -3.037146586654936 1.3683572129666098e-22 8.075204629310093 23.50913132231292 0.0 16.412197549262196 0.0 0.3989339639070151 1078185871.2048337 1078185872.6127067 0.0009180226855973785 3.037146586654936 15.433926693002828 FENLCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FENLCK 6 0 P08238;Q58FF7;P07900;P07900-2;Q58FG0;Q58FF8 P08238;Q58FF7;P07900;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA5P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 2 0 43145500.0 1400500.0 22347000.0 19398000.0 False True 1918302.6970894204 21359635.64835323 14816591.914350362 1.0 11.13465339998819 7.723802889309964 20.871398956590358 -9.666435238898407 7.333568564571685 0.999999998608412 9.429228144649649 0.8906277289295749 1.3924738900142488 3.325419570458761e-08 0.0 1.3482570465125374 0.44941901550417923 2.1555830557215486e-10 9.666435238898407 8.429228146041236 FENLCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FENLCK 6 0 P08238;Q58FF7;P07900;P07900-2;Q58FG0;Q58FF8 P08238;Q58FF7;P07900;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA5P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 2 0 7099400.0 2494800.0 2178700.0 2425900.0 False True 3229567.7798600807 2057453.4297687782 1984411.0918359987 1.0 0.6370677347598248 0.6144509814009763 21.622909668120496 -13.999999999999998 0.39473802922115575 6.91480865074733 0.6129566092111371 0.9998301926104983 0.0023020545520099126 26.008788984703326 0.2064632915632074 131.49916454680687 0.0058727482879550735 1.0000000000000041e-14 13.999999999999998 -6.3018520415361925 FENVNGYTNCCFGFHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FENVNGYTNCCFGFHR 16 0 P08243-2;P08243;F8WEJ5;C9J057;C9JT45;C9JM09;C9JLN6 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 26977300.0 8535600.0 9037200.0 9404500.0 False True 11190254.258867975 7688884.986729693 8431412.554334054 1.0 0.6871054766817705 0.7534603199612186 23.415739481029917 -10.836521508058809 7.287335253105483 1.0180051374937718 0.7202828983214946 0.9595037171666699 0.02708925133283227 0.007730206881074865 0.00017341330135493775 0.025586431522613584 0.008743018272773862 1.4570635431310886e-11 10.836521508058809 -0.29772223917227714 FENVNGYTNCCFGFHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FENVNGYTNCCFGFHR 16 0 P08243-2;P08243;F8WEJ5;C9J057;C9JT45;C9JM09;C9JLN6 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 20700100.0 8535600.0 5793500.0 6371000.0 False True 11691441.985916771 5537524.013457483 4866301.014863712 1.0 0.47363909602663645 0.41622761509876544 23.478949542552808 -13.999999999999998 0.31289711330114117 6.175142883994058 0.40390411060869424 0.9996783454023865 0.004711603936068819 17.47860280853256 0.1780918396388513 58.98583514756838 0.01966190100263726 1.0000000000000041e-14 13.999999999999998 -5.771238773385363 FEPDNK(ub)NTQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FEPDNKNTQR 10 1 Q7Z3D4 Q7Z3D4 LYSMD3 LysM and putative peptidoglycan-binding domain-containing protein 3 1 2538990.0 474690.0 1005200.0 1059100.0 True False 720139.4344874806 825814.2063365531 849768.4207799789 1.0 1.146742098527462 1.180005399072132 19.457916744835885 -13.999999999995254 0.20854444619211512 0.15637460382308743 1.1998762292169003 0.9994892387253315 0.0017673846172551082 12.712643099965012 0.14474981537345094 4.391324557678107 0.01990580438022274 1.000000000010929e-14 13.999999999995254 1.0435016253938127 FEPDNK(ub)NTQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FEPDNKNTQR 10 1 Q7Z3D4 Q7Z3D4 LYSMD3 LysM and putative peptidoglycan-binding domain-containing protein 3 1 2680100.0 474690.0 1332200.0 873210.0 True False 614495.5625387934 1258061.8989020824 714294.7398912193 1.0 2.0473083543588 1.1624082962293572 19.229043066928334 -10.26703328958149 4.20390246372875 0.999503316127867 1.6048583252954713 0.3838404817918336 0.3612589360465921 255626196.07868928 1050.6341434726723 1241089.9833027697 0.12366854272063424 5.4071287458290946e-11 10.26703328958149 0.6053550091676043 FEPIHGNFLLTGAYDNTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FEPIHGNFLLTGAYDNTAK 19 0 O43172-2;O43172 O43172-2 PRPF4 U4/U6 small nuclear ribonucleoprotein Prp4 0 5656400.0 1071200.0 2611700.0 1973500.0 False True 1404353.5735155556 2222044.5403268626 1769301.1511487297 1.0 1.5822543426612712 1.2598687285849184 20.421474777429907 -10.145485136047922 4.580504180904654 0.9999627092920192 1.4210615356279508 0.6946062614677724 0.1316133760913649 6.897474757441107e-05 1.2867494097201319e-05 0.12744959411837017 0.04247803443722876 7.153438766685776e-11 10.145485136047922 0.42109882633593154 FEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIK 34 2 H3BQQ9;B0QYN7;P63279 H3BQQ9 UBE2I SUMO-conjugating enzyme UBC9 0 320912000.0 113822000.0 105980000.0 101110000.0 False True 172676295.50282094 87067040.97448069 81125564.18191265 1.0 0.5042211539282084 0.46981297546186546 27.363494806599522 -13.999999999999996 0.3788680619120776 8.303172149913495 0.46672992287574133 0.9998056883558755 0.0033765790234813234 23.892565263819545 0.20062184220263213 142.25237067005833 0.009357810611295609 1.0000000000000082e-14 13.999999999999996 -7.836442227037754 FEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FEPPLFHPNVYPSGTVCLSILEEDKDWRPAITIK 34 2 H3BQQ9;B0QYN7;P63279 H3BQQ9 UBE2I SUMO-conjugating enzyme UBC9 0 219258000.0 113822000.0 33644000.0 71792000.0 False True 147344822.76704922 31771681.824547093 58726592.648126416 1.0 0.21562808402693473 0.3985657014971785 27.134621128691972 -10.699172322939265 10.068696195313345 1.0006482313360658 0.3070968928461893 0.9503188511797293 0.07468396959375916 0.0010875287133809213 3.249258609337253e-05 0.07236373863653701 0.024104147538774184 1.9990685053881878e-11 10.699172322939265 -0.6935513384898766 FEPVHFVASSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FEPVHFVASSSK 12 0 O15226;O15226-2 O15226 NKRF NF-kappa-B-repressing factor 0 5965100.0 1222400.0 1793200.0 2949500.0 False True 1602578.2377384386 1525661.549838853 2644314.0336018144 1.0 0.9520044100885018 1.6500374030621276 20.611963360141345 -6.890421771809542 1.0198585472166688 0.9628722910679106 1.7105789975925008 0.9811677613747319 0.04368692550573689 0.1188026655331298 0.2198416328757251 0.03262012116409418 0.08144896877934872 1.286999055514879e-07 6.890421771809542 0.7477067065245901 FEPVHFVASSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FEPVHFVASSSK 12 0 O15226;O15226-2 O15226 NKRF NF-kappa-B-repressing factor 0 5589100.0 1222400.0 1434100.0 2932600.0 False True 1674354.3141178903 1370736.720065483 2239980.278792861 1.0 0.8186658633167712 1.3378173663158999 20.675173421664237 -6.812353529393791 1.4046822916304074 0.9014451741449039 1.347390763774883 0.8658599636488371 0.07879095533581544 0.20361482011181722 0.7913841343299569 0.04410003221540733 0.10190490567523426 1.540445970861922e-07 6.812353529393791 0.4459455896299791 FEPYANPTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEPYANPTK 9 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 12708200.0 3266400.0 1126600.0 8315200.0 False True 3162709.9199369634 1576457.2551413875 6137199.669347085 1.0 0.49845142142305865 1.9404876908437454 21.59272980894178 -6.812761614272957 1.4029038145207555 0.7275412293220089 1.967339645358192 0.8669172561132484 0.21805515194318786 0.20305590935921053 0.7871210986313022 0.12219869834527627 0.2823323301991807 1.5389991704093778e-07 6.812761614272957 1.239798416036183 FEPYANPTK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 FEPYANPTKR 10 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 39550000.0 12926000.0 15144000.0 11480000.0 True False 16946111.175562058 12884574.230849639 10292159.723935876 1.0 0.7603263130617512 0.607346406341189 24.014450903270898 -9.251910201385886 0.08082387586105359 1.7221445287567099 3.989116877774458e-11 0.9999808151255971 0.0007077813579114209 0.707941614933777 0.028899278084524735 0.3568474634453375 0.24868795461528212 5.598733539533492e-10 9.251910201385886 -1.7221445287168187 FEPYANPTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEPYANPTKR 10 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 69853000.0 15556000.0 22241000.0 32056000.0 True False 15062183.294923892 31121947.285282813 23659571.940613586 1.0 2.0662308163366476 1.5707929904549163 23.8444275710382 -10.20071749238198 5.054374914154507 0.9999253292575894 1.8185119033965051 0.7844473419357477 0.202261645449866 0.00017020573770909427 2.691595706055266e-05 0.19585670868295382 0.06527966536662608 6.299158084789063e-11 10.20071749238198 0.8185865741389158 FEPYANPTK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FEPYANPTKR 10 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 37730000.0 12926000.0 12871000.0 11933000.0 True False 17705091.512015585 12302316.661294777 9114671.167849407 1.0 0.6948462623277486 0.5148050865291333 24.07766096479379 -10.24089672898504 0.09661599713801408 1.8442968031854534 4.902475920891002e-16 0.9999311336832436 0.0016618878458703557 1.968892374472644 0.048518452436784335 0.6817902559147831 0.28640525915924453 5.7425299776564425e-11 10.24089672898504 -1.844296803185453 FEPYANPTK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FEPYANPTKR 10 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 61469000.0 15556000.0 32095000.0 13818000.0 True False 12935503.24764746 31922097.864641298 16707279.91278666 1.0 2.4677894051355804 1.2915832954411852 23.624832846472476 -6.5909876989972105 2.225070285412798 1.9928254977795732 1.2950443678645298 0.0 0.6358857795213838 0.6667231520147233 6.2245011816472005 0.2384370085545277 0.7086123946329693 2.5645566742632054e-07 6.5909876989972105 -0.6977811299150434 FEQIYLSK(ub)PTHWER ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEQIYLSKPTHWER 14 1 P30876;C9J2Y9 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 8414900.0 1894000.0 3130400.0 3390500.0 True False 1833876.0067231841 4380385.044820344 2502426.337180261 1.0 2.3885939009842474 1.3645559067276634 20.806464667072376 -10.10113038231398 4.6631136401542665 0.9999445482023704 1.8765749038732118 0.49417740611937 0.41806176058265726 291039682.5584831 19.212776534338143 176239.49017989667 0.14311366042979726 7.922634443162314e-11 10.10113038231398 0.8766303556708414 FEQIYLSK(ub)PTHWER ddPTM_RPMI8226_Bortezomib_8h_R1 1 FEQIYLSKPTHWER 14 1 P30876;C9J2Y9 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 35702000.0 7211000.0 8352000.0 20139000.0 True False 10939614.194714919 6861520.345526149 16158517.822762746 1.0 0.627217763204213 1.4770646875800386 23.38305852398861 -6.787446298485677 1.50631397283791 0.7909644263654442 1.485507328571151 0.7930385702054754 0.1582329526710403 0.23916137444594263 1.0720278758679118 0.08269352447592523 0.19398921643550676 1.6313746199908652e-07 6.787446298485677 0.6945429022057069 FEQIYLSK(ub)PTHWER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FEQIYLSKPTHWER 14 1 P30876;C9J2Y9 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 6666500.0 1746900.0 2998900.0 1920700.0 True False 2392776.138197432 2866398.6819638666 1467070.2180581882 1.0 1.1979385100869622 0.6131247276493602 21.190253997784463 -6.815399189018688 1.391752410298662 1.10720741690034 0.6015830481797843 0.8734548701794177 0.08639551013313329 0.19952623877862605 0.7606235418384407 0.04879747448076818 0.11262653036535131 1.5296807836822078e-07 6.815399189018688 -0.5056243687205558 FEQIYLSK(ub)PTHWER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FEQIYLSKPTHWER 14 1 P30876;C9J2Y9 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 7530900.0 1894000.0 3431000.0 2205900.0 True False 1574944.9184266066 3412516.5219998187 2667143.491070785 1.0 2.166752933435268 1.6934836640098507 20.586869942506652 -10.306362226664586 5.219316404331438 0.9997770419391607 1.930118298722659 0.8373956379033639 0.19321137017235626 0.0005013859930669954 6.663325609570464e-05 0.18711957990375797 0.06235870158123746 4.9389857522957146e-11 10.306362226664586 0.9303412567834983 FEQIYLSK(ub)PTHWER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FEQIYLSKPTHWER 14 1 P30876;C9J2Y9 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 36563400.0 7211000.0 9574400.0 19778000.0 True False 9334781.650060548 9041576.223425996 16178606.939417258 1.0 0.9685900069625464 1.733153226922273 23.15418484608106 -6.897319125136639 0.9780548331534392 0.9658308232290217 1.8091785601831036 0.9851844303842328 0.04299706867002947 0.11340680489853104 0.18875681912517198 0.03313037261271345 0.0850971755729605 1.2667207212135391e-07 6.897319125136639 0.8433477369540819 FEQK(ub)GFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEQKGFR 7 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;O60361;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 1 7133200.0 1980900.0 3144400.0 2007900.0 True False 1918017.4137898386 4399975.317829374 1481970.7542911805 1.0 2.2940226122011054 0.7726576117799332 20.871184388050498 -6.681428732520617 1.897140984421098 1.8177265987877866 0.7784395036867447 0.33045935417695416 0.5482733847526406 0.43539949310853077 3.031079004669123 0.23180892138615294 0.6101898837116067 2.0824341034442448e-07 6.681428732520617 -1.039287095101042 FEQK(ub)GFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FEQKGFR 7 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;O60361;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 1 13888300.0 2894500.0 5363400.0 5630400.0 True False 4391168.116294876 4406259.365564537 4517548.972108017 1.0 1.0034367277384941 1.0287806917125681 22.066173338564763 -6.9316472430731935 0.7331799749432287 0.9996371748500383 1.0342082502728236 0.9968514590465712 0.0007201291407857827 0.09179162744728947 0.07356478308272592 0.0006626173952144405 0.0022727775603627407 1.1704497061187309e-07 6.9316472430731935 0.03457107542278526 FEQK(ub)GFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FEQKGFR 7 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;O60361;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 1 5796400.0 2291100.0 1827500.0 1677800.0 True False 3138181.5846494623 1746755.0072656495 1281538.1953756583 1.0 0.556613745938084 0.4083696754975405 21.581497402730857 -13.999999999999998 0.15305326687390775 3.1546658560281444 0.2508613789633941 0.9995563700365698 0.005294075166696462 11.970497558931806 0.12335907904576589 7.664640268922719 0.14240734731892465 1.0000000000000041e-14 13.999999999999998 -2.9038044770647504 FEQK(ub)GFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FEQKGFR 7 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;O60361;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 1 7992200.0 1980900.0 4266000.0 1745300.0 True False 1647206.1187493473 4243018.2112653 2110234.1606445583 1.0 2.575887840003194 1.2810990298207297 20.651589663484774 -6.597611903981265 2.1992499396819425 2.0614684181960024 1.2851648220530312 0.01371174894228 0.6815663531087988 0.6477087343767644 5.916760795285572 0.25755708420155454 0.7586951807656492 2.5257368236141065e-07 6.597611903981265 -0.7763035961429712 FEQK(ub)GFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FEQKGFR 7 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;O60361;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 1 12931400.0 2894500.0 4241500.0 5795400.0 True False 3746987.3091249852 4005456.7964218496 4740696.6658256 1.0 1.068980614550633 1.2652022210698841 21.837299660657212 -6.952639941090717 0.5290671094725271 0.9968844180176339 1.3461919202951822 0.9993925078522848 0.002769011786126104 0.08244264777175536 0.0317066840644078 0.003093513028058291 0.016224546140540946 1.1152187406738289e-07 6.952639941090717 0.34930750227754825 FEQLK(ub)QER ddPTM_RPMI8226_Bortezomib_1h_R1 1 FEQLKQER 8 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 23578600.0 9315700.0 9200000.0 5062900.0 True False 12212972.91336714 7827395.861319122 4539039.674766109 1.0 0.6409083125658955 0.3716572293219545 23.54191109183487 -7.797925786584001 0.1988654102659054 1.2303992741408407 1.5263146145678708e-16 0.9998930749493451 0.0026615487680884094 0.1257968183138591 0.028134390474477713 0.057530301650865284 0.09009325456109628 1.5924808312342655e-08 7.797925786584001 -1.2303992741408405 down FEQLK(ub)QER ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEQLKQER 8 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 26675500.0 8748400.0 11658700.0 6268400.0 True False 8470686.830632057 16314079.709317314 4626517.992030889 1.0 1.9259453259824983 0.5461797944530635 23.01404752199541 -6.72588214335883 1.7382656073901896 1.5597651886093618 0.5475999976937284 0.5400876107982957 0.38938656278229894 0.34400121983647947 2.034351134493171 0.17766134156809615 0.44292118663637264 1.8798268855079975e-07 6.72588214335883 -1.0121651909156335 FEQLK(ub)QER ddPTM_RPMI8226_Bortezomib_8h_R1 1 FEQLKQER 8 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 40479600.0 18585700.0 14151600.0 7742300.0 True False 28195865.696673546 11626136.41304453 6212031.011429367 1.0 0.41233479184915195 0.22031708755664278 24.748980302857966 -13.999999999999988 0.15639577080184658 3.873223348163316 0.02384098993434493 0.9995463157675801 0.00706481535983071 11.987602636991193 0.1248425137796519 10.45237030454746 0.17829559879230164 1.0000000000000286e-14 13.999999999999988 -3.849382358228971 FEQLK(ub)QER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FEQLKQER 8 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 15361200.0 9315700.0 2029200.0 4016300.0 True False 12759966.037326612 1939543.2343329447 3067732.658294947 1.0 0.15200222544944217 0.24041855983949617 23.60512115335776 -10.353496698285099 5.768832330138492 1.0001498211880089 0.19621039518836864 0.9910067200615221 0.03609581736382956 6.956631185915325e-05 7.79608335895579e-06 0.034955999042972107 0.011649874959820127 4.431015831472016e-11 10.353496698285099 -0.8039394259996402 FEQLK(ub)QER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FEQLKQER 8 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 27283000.0 8748400.0 14293400.0 4241200.0 True False 7274682.219832807 14216398.617182227 5128015.310906842 1.0 1.954229502757436 0.7049126210525659 22.794452797429685 -6.702531006163192 1.82151099455144 1.5910400386756263 0.7084016053526334 0.429796587306281 0.40260562809651723 0.39025548695032947 2.518974484853463 0.17620309562333336 0.4517933948864694 1.9836680291326477e-07 6.702531006163192 -0.8826384333229929 FEQMK(ub)QDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FEQMKQDR 8 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;Q4VXU2;A0A6I8PS38;A0A6I8PLA1;Q4VXU2-2;H0YAW6 P11940 PABPC1;PABPC1L Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like 1 23589400.0 2551100.0 14015500.0 7022800.0 True False 3344516.8048875458 11924442.031991092 6296148.023454428 1.0 3.565370643246636 1.8825284460384484 21.67336636358503 -10.433909757853694 6.236868910312419 0.9994919770638772 2.7239495446424593 0.5832062949296254 0.6870174501306943 0.004854391435747137 0.0004406097613032305 0.6653621136025805 0.22173392857583862 3.68205475191125e-11 10.433909757853694 1.724457567578582 FEQMK(ub)QDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEQMKQDR 8 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;Q4VXU2;A0A6I8PS38;A0A6I8PLA1;Q4VXU2-2;H0YAW6 P11940 PABPC1;PABPC1L Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like 1 42531800.0 14347200.0 17247000.0 10937600.0 True False 13891755.989260212 24133817.041916836 8072714.43903342 1.0 1.7372761989610828 0.5811154792291541 23.727725639115878 -6.734435954133499 1.7069679626621441 1.4414886226763113 0.5812187528325201 0.5797067364368502 0.3098417256859586 0.3280021051363747 1.8742283135836768 0.1437262609916448 0.35488192346152 1.843164282315046e-07 6.734435954133499 -0.8602698698437912 FEQMK(ub)QDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FEQMKQDR 8 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;Q4VXU2;A0A6I8PS38;A0A6I8PLA1;Q4VXU2-2;H0YAW6 P11940 PABPC1;PABPC1L Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like 1 17366800.0 6577100.0 6960800.0 3828900.0 True False 9977941.550417345 5718590.855021365 3072116.2367335134 1.0 0.5731233066585938 0.30789078300473877 23.25031078756107 -8.575257585190043 0.19787357862692337 1.3306864880774232 2.555789569441843e-19 0.9997015747424007 0.004925261302744249 0.19247172322938505 0.05243543914342593 0.16484708810750456 0.12943022999017428 2.6591474202239368e-09 8.575257585190043 -1.3306864880774232 down FEQMK(ub)QDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FEQMKQDR 8 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;Q4VXU2;A0A6I8PS38;A0A6I8PLA1;Q4VXU2-2;H0YAW6 P11940 PABPC1;PABPC1L Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like 1 22502200.0 2551100.0 11645100.0 8306000.0 True False 3494310.610885271 11130580.97680395 6344293.867439638 1.0 3.1853438964843646 1.8156067316043019 21.73657642510792 -10.338579051581448 6.047724351024499 0.9998499841489212 2.5004753140443343 0.6153856968093481 0.5591928559471084 0.0011311863164969078 0.0001237142332995887 0.541487897357625 0.18047871820010888 4.585861649744114e-11 10.338579051581448 1.500625329895413 FEQMK(ub)QDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FEQMKQDR 8 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;Q4VXU2;A0A6I8PS38;A0A6I8PLA1;Q4VXU2-2;H0YAW6 P11940 PABPC1;PABPC1L Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like 1 23724400.0 14347200.0 4682500.0 4694700.0 True False 11930332.488727659 4657274.443096522 5676340.064159757 1.0 0.39037256065553366 0.47579060093446945 23.508130914550154 -10.711497082751686 6.854278574891725 1.0059709190982369 0.43308158079562303 0.9832587770996116 0.034871768918648925 0.0031870222254595736 0.0001341445095967721 0.03381940064695512 0.01125481502289339 1.943134744233542e-11 10.711497082751686 -0.5728893383026139 FEQMK(ub)QDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FEQMKQDR 8 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;Q4VXU2;A0A6I8PS38;A0A6I8PLA1;Q4VXU2-2;H0YAW6 P11940 PABPC1;PABPC1L Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like 1 17742600.0 6577100.0 9759000.0 1406500.0 True False 8514185.604023466 9215903.071149545 1150531.4319087071 1.0 1.0824174500958113 0.13513111945375159 23.02143710965352 -6.885712142189439 1.0473939018876461 1.0562525901044921 0.06017837337286941 0.9780096941641068 0.06353573986641334 0.12269201747871583 0.2427120624741445 0.046460150737344476 0.11417707919231969 1.3010316383296555e-07 6.885712142189439 -0.9960742167316228 down FESGTCSK(ub)MELIDDNTVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FESGTCSKMELIDDNTVVR 19 1 H0YBR2;H0YBB3;A0A2U3TZN9;Q6NXG1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1 H0YBR2 ESRP1 Epithelial splicing regulatory protein 1 1 14076400.0 3603500.0 6327900.0 4145000.0 True False 4724223.396343634 5383801.985961003 3716115.1616475745 1.0 1.1396162997134844 0.7866086867364704 22.171645757000988 -6.7993848534447245 1.4582984854636198 1.0770916623551854 0.78180196102759 0.8304070982066275 0.05977931266360297 0.22162747569761534 0.9305466566496312 0.03224890844543812 0.07503150108579512 1.5871396690375492e-07 6.7993848534447245 -0.29528970132759536 FESGTCSK(ub)MELIDDNTVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FESGTCSKMELIDDNTVVR 19 1 H0YBR2;H0YBB3;A0A2U3TZN9;Q6NXG1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1 H0YBR2 ESRP1 Epithelial splicing regulatory protein 1 1 18922000.0 6004300.0 6641200.0 6276500.0 True False 5813696.783087656 9293065.793400483 4632496.359036098 1.0 1.5984778945531681 0.7968245561949961 22.471024398118022 -6.706822646456187 1.8062702852628418 1.3691090054663688 0.7988557711178698 0.450148435613533 0.2523231138119562 0.3814825275252228 2.4241015718515104 0.11124458976912495 0.28373541265162217 1.9641622211995793e-07 6.706822646456187 -0.5702532343484991 FESGTCSK(ub)MELIDDNTVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FESGTCSKMELIDDNTVVR 19 1 H0YBR2;H0YBB3;A0A2U3TZN9;Q6NXG1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1 H0YBR2 ESRP1 Epithelial splicing regulatory protein 1 1 45886100.0 9865100.0 10728000.0 25293000.0 True False 14966077.935415655 8813504.581753414 20293827.46368429 1.0 0.5888987495446071 1.355988359225437 23.835192857252217 -6.761123066286362 1.6081181138231349 0.7615397314348734 1.3589587213625853 0.695557990469559 0.17294024841912467 0.28104734461527986 1.4326815169500358 0.08483872294693152 0.203665510683999 1.7333127582859052e-07 6.761123066286362 0.5974189899277119 FESGTCSK(ub)MELIDDNTVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FESGTCSKMELIDDNTVVR 19 1 H0YBR2;H0YBB3;A0A2U3TZN9;Q6NXG1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1 H0YBR2 ESRP1 Epithelial splicing regulatory protein 1 1 15477800.0 3603500.0 6306100.0 5568200.0 True False 4935811.330925894 6027475.650515959 4253105.840678715 1.0 1.2211722139276509 0.8616832280501467 22.23485581852388 -6.740234698644098 1.6857130815148944 1.131559544047633 0.8614563359310035 0.6060522345896548 0.09292674074390365 0.3173899198405024 1.7709638195131174 0.04360748396711998 0.10698641179795967 1.81871773319053e-07 6.740234698644098 -0.27010320811662947 FESGTCSK(ub)MELIDDNTVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FESGTCSKMELIDDNTVVR 19 1 H0YBR2;H0YBB3;A0A2U3TZN9;Q6NXG1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1 H0YBR2 ESRP1 Epithelial splicing regulatory protein 1 1 20474200.0 6004300.0 5981300.0 8488600.0 True False 4992841.485590749 5949077.549704901 10263527.01314811 1.0 1.1915214145840263 2.0556484804832005 22.2514296735523 -6.942120780194101 0.6395383872289753 0.9905432013730717 2.3039650428374796 0.9984285961685423 0.01820315537062616 0.08681247995398092 0.05030451328777742 0.01801818568010736 0.0737068224492718 1.14256053688967e-07 6.942120780194101 1.3134218414644079 up FESGTCSK(ub)MELIDDNTVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FESGTCSKMELIDDNTVVR 19 1 H0YBR2;H0YBB3;A0A2U3TZN9;Q6NXG1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1 H0YBR2 ESRP1 Epithelial splicing regulatory protein 1 1 50319100.0 9865100.0 15947000.0 24507000.0 True False 12770566.420193098 15059535.43146036 20046977.463054854 1.0 1.1792378611842849 1.5697798205219884 23.606319179344666 -6.9583352352176595 0.45829382884725023 0.9884203683152364 1.7762958333084595 0.999703383104193 0.004096966004539519 0.08030125709380297 0.02336982627423012 0.005288795355566616 0.03226888262109862 1.1006893510472663e-07 6.9583352352176595 0.7878754649932231 FETSK(ub)YYVTIIDAPGHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FETSKYYVTIIDAPGHR 17 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 64105000.0 16132800.0 17450200.0 30522000.0 True False 21150257.03025745 14846698.180346861 27363876.227697786 1.0 0.7019630144024847 1.2937845714381233 24.334171860134756 -6.769777528157723 1.5751579362251977 0.8290055381494454 1.297096956258256 0.7297590448298331 0.12560139857338373 0.26679069050611354 1.306304267851964 0.06285158557021595 0.1496523950581202 1.6991138182022012e-07 6.769777528157723 0.4680914181088105 FETSK(ub)YYVTIIDAPGHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FETSKYYVTIIDAPGHR 17 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 63134000.0 18440500.0 30246500.0 14447000.0 True False 17855116.421319373 42324085.18341378 10662897.299290132 1.0 2.3704177662419474 0.5971900181260322 24.089834205019443 -6.700374813242845 1.8299462504522432 1.8506789828847983 0.6024963123769201 0.4191973777411949 0.5784318827587959 0.3947268399711966 2.5701735600670683 0.2521710148161253 0.64811792733633 1.993541067865255e-07 6.700374813242845 -1.248182670507878 FETSK(ub)YYVTIIDAPGHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FETSKYYVTIIDAPGHR 17 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 288357000.0 79750000.0 50190000.0 158417000.0 True False 120986580.50596516 41233202.363740146 127105810.5133624 1.0 0.34080806475646425 1.0505777581431481 26.85027179576284 -11.961610012151185 14.619769396113677 0.9273938068264141 0.7261236203059841 0.0 0.33103214157258326 0.0 0.0 0.0 0.09623146815316296 1.0924208684514268e-12 11.961610012151185 -0.20127018652043005 FETSK(ub)YYVTIIDAPGHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FETSKYYVTIIDAPGHR 17 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 68313200.0 16132800.0 19280400.0 32900000.0 True False 22097532.132527098 18428528.176243316 25129697.596769106 1.0 0.8339631804004446 1.137217380024927 24.397381921657647 -6.758052916264871 1.6199058891336424 0.9033229410622144 1.138215858458647 0.6829290746734427 0.06981715437467151 0.2862000490227909 1.4797436996481172 0.03401400750516165 0.08189548591886997 1.7456094475709987e-07 6.758052916264871 0.2348929173964326 FETSK(ub)YYVTIIDAPGHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FETSKYYVTIIDAPGHR 17 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 64046500.0 18440500.0 32036000.0 13570000.0 True False 15334092.802664125 31863415.7093519 16407424.259409107 1.0 2.0779459286835666 1.0699964106489888 23.87023948045372 -6.63034200234428 2.0793571410663434 1.7100048908382997 1.0740719066219346 0.11863649038414636 0.4623449846707048 0.5581469771033041 4.5994265516722805 0.1818363940886703 0.5121204699177148 2.342383486426871e-07 6.63034200234428 -0.635932984216365 FETSK(ub)YYVTIIDAPGHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FETSKYYVTIIDAPGHR 17 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 187724000.0 79750000.0 56464000.0 51510000.0 True False 103237947.10752027 53321728.7641549 42135708.537232436 1.0 0.5164935012570657 0.40814167384933503 26.62139811785529 -13.999999999999998 0.2101657806818051 3.7981969959197723 0.3444249781400666 0.9994901051326952 0.005809978727878221 12.750563886356074 0.145304471782262 14.733885353386157 0.06410775755624178 1.0000000000000041e-14 13.999999999999998 -3.4537720177797055 FETVQK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FETVQKLR 8 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX45;Q5JX52;Q5JX61;Q5JX55;Q5JX54;E7EV27;Q5JX57 Q99829 CPNE1 Copine-1 1 9379200.0 3307500.0 4832000.0 1239700.0 True False 4336164.529875557 4111084.4349884773 1111427.736042099 1.0 0.9480923536604043 0.25631585895427167 22.047988068158997 -6.921938228630045 0.8102375638151194 1.0142242902756233 0.13963719345478331 0.9947021719646482 0.02467482723746841 0.09704510662649239 0.09980831476054948 0.021480910042041827 0.0655861045523649 1.196910760409151e-07 6.921938228630045 -0.87458709682084 down FETVQK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FETVQKLR 8 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX45;Q5JX52;Q5JX61;Q5JX55;Q5JX54;E7EV27;Q5JX57 Q99829 CPNE1 Copine-1 1 19892400.0 5087400.0 6139000.0 8666000.0 True False 4925903.271701969 8590334.714462068 6396114.625572664 1.0 1.7439105562245412 1.29846533169189 22.23195686772418 -10.252224395586122 4.88326698248928 0.9998837477024612 1.5211879439588156 0.646057702843599 0.18185225141288344 0.00023021487230916377 3.525371041604587e-05 0.17611665377697572 0.05869256176573055 5.5946845508426795e-11 10.252224395586122 0.5213041962563544 FETVQK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FETVQKLR 8 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX45;Q5JX52;Q5JX61;Q5JX55;Q5JX54;E7EV27;Q5JX57 Q99829 CPNE1 Copine-1 1 12919800.0 3307500.0 4154900.0 5457400.0 True False 4530372.131826666 3971322.779583063 4168474.518681088 1.0 0.8765996840930169 0.9201174643903569 22.11119812968189 -10.19436910849702 6.889900293416156 1.0000002859922772 0.8983585747656271 0.879132969979864 0.017766059411171084 7.806037237079635e-08 9.114911497168456e-09 0.017201961502653015 0.005733971018933089 6.391913534506966e-11 10.19436910849702 -0.10164171122665011 FETVQK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FETVQKLR 8 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX45;Q5JX52;Q5JX61;Q5JX55;Q5JX54;E7EV27;Q5JX57 Q99829 CPNE1 Copine-1 1 19625000.0 5087400.0 9646400.0 4891200.0 True False 4230398.510033538 9594432.928539505 5913927.305646409 1.0 2.267973786815522 1.3979598592472853 22.012362143158455 -10.183221490197473 4.5365659597708365 0.9998371983109943 1.8329668230435436 0.5499951890911668 0.35518169865273924 249274328.63735273 132.12303133495396 427443.2801343836 0.12158814272172985 6.558107175166065e-11 10.183221490197473 0.8331296247325494 FETVQK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FETVQKLR 8 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX45;Q5JX52;Q5JX61;Q5JX55;Q5JX54;E7EV27;Q5JX57 Q99829 CPNE1 Copine-1 1 20035000.0 8109200.0 9459000.0 2466800.0 True False 10497519.256229516 8932598.334870744 2017867.711505437 1.0 0.8509246915236565 0.1922232922133464 23.32354509880898 -6.942597307436236 0.6349578397767123 1.0071920555532228 0.00015367609374161115 0.9984844921760527 0.013663061232507968 0.08660188773951191 0.049365307460826326 0.013577775874006912 0.05607675789328769 1.1413075561359103e-07 6.942597307436236 -1.0070383794594813 down FEVK(ub)K(ub)EPVETDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FEVKKEPVETDR 12 2 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 2 71282000.0 19900000.0 23405000.0 27977000.0 True False 26089092.711874153 19913065.23197545 25082208.414333947 1.0 0.7632716649786846 0.9614059289581223 24.636943437311334 -10.068966429800792 6.166887849968504 1.0000002495927134 0.862338797086609 0.3915940784843013 0.08088797455193097 2.7759517351358504e-07 4.191784641496309e-08 0.07831958638290011 0.02610648152900506 8.53166059703883e-11 10.068966429800792 -0.1376614525061044 FEVK(ub)K(ub)EPVETDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FEVKKEPVETDR 12 2 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 2 86632000.0 19900000.0 19272000.0 47460000.0 True False 27257567.77727917 18420499.316018414 36250925.469381824 1.0 0.675793947080378 1.3299398451684 24.700153498834226 -6.771924637381827 1.566929106400506 0.8145050654050625 1.3339049989455085 0.737942386969904 0.13671083897885464 0.2633182741346129 1.2761580541590796 0.06875775767904377 0.1633952503248241 1.6907342973521763e-07 6.771924637381827 0.519399933540446 FEVK(ub)KEPVETDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FEVKKEPVETDR 12 2 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 7632000.0 2429000.0 2088200.0 3114800.0 True False 3184442.522469463 1776648.6997398485 2792510.3752713823 1.0 0.5579151412543311 0.876922838320176 21.602609401628825 -9.985065087805806 5.527158484026106 1.0000006941236834 0.7174189897869043 0.5112936164534037 0.1302343469731762 1.1138606518607542e-06 2.0465765599622313e-07 0.12609917426092582 0.04203295474409717 1.0349870413286358e-10 9.985065087805806 -0.2825817043367791 FEVK(ub)KEPVETDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FEVKKEPVETDR 12 2 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 27571200.0 11104000.0 8811000.0 7656200.0 True False 16845579.81113777 7238608.209342785 6142948.714168337 1.0 0.42970371400079943 0.3646623495919572 24.005866749914144 -13.999999999999998 0.30645147795760924 6.39975639847041 0.3497038340366116 0.9996641697771842 0.005230299326789164 17.021095969082808 0.17601365743972175 58.49087227235681 0.02287224938877907 1.0000000000000041e-14 13.999999999999998 -6.050052564433798 FEVK(ub)KEPVETDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FEVKKEPVETDR 12 2 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 8957500.0 2429000.0 2129800.0 4398700.0 True False 3327066.941256839 2035698.3936932343 3359817.654070157 1.0 0.611859764061202 1.0098437192252423 21.665819463151717 -10.903564464313938 11.342757607679127 1.0152390323127862 0.8108517416443021 0.2314611588981096 0.16247626932776615 0.05842340133536858 0.0004967117527012311 0.1467892572813452 0.05243899043836242 1.2486350902236527e-11 10.903564464313938 -0.20438729066848416 FEVK(ub)KEPVETDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FEVKKEPVETDR 12 2 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 41758000.0 11104000.0 11364000.0 19290000.0 True False 14374346.892563073 10731583.410241168 15779417.932114432 1.0 0.7465788526220569 1.097748513379645 23.776993072006594 -6.713103440847673 1.7842455633137313 0.8446952856889611 1.0969966802522182 0.4797406360231198 0.10674041908341553 0.3688928933823839 2.2911405497524284 0.047574428155072304 0.12040408471745619 1.935960799264186e-07 6.713103440847673 0.25230139456325706 FEVQGLQPNGEEMTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FEVQGLQPNGEEMTLK 16 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 10777350.0 2624300.0 849150.0 7303900.0 False True 2540993.032969195 1188220.0232587503 5390789.477696777 1.0 0.46762033891540994 2.1215286337867463 21.276960989062324 -6.820066129394881 1.3715185212286507 0.7130658402763845 2.1577063130704857 0.8845473408223717 0.23422510625468143 0.19339761388043217 0.7148049124241512 0.13419873957783524 0.30931157260688485 1.5133307981917678e-07 6.820066129394881 1.4446404727941011 up FEVYEK(ub)ND ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FEVYEKND 8 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 2979780.0 753940.0 1352900.0 872940.0 True False 626934.5152051502 1345611.6591703747 1055467.717981471 1.0 2.1463352655421333 1.683537422781856 19.257955232420013 -10.248170529938914 5.0812200932796205 0.9998615860479758 1.9149363441623999 0.8390005469644475 0.1889364281386559 0.0002962988021564675 4.384113852761922e-05 0.1829640980666479 0.0609789699725419 5.6471519037768955e-11 10.248170529938914 0.9150747581144241 FEVYEK(ub)ND ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FEVYEKND 8 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 22306400.0 1820600.0 1668800.0 18817000.0 True False 2356802.589391242 1575929.8130069035 15392499.078724585 1.0 0.6686728112488893 6.531093927005759 21.16839948988349 -6.8935118198676175 1.00135999786951 0.7110091945071104 7.071456440132076 0.9830530665231182 0.35003965251884395 0.11634064906970772 0.20556581681334327 0.2650415769152591 0.6696894270761723 1.2778744301417988e-07 6.8935118198676175 6.360447245624965 up FFADLLDYIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FFADLLDYIK 10 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 42785000.0 13133000.0 15075000.0 14577000.0 False True 19923721.150907096 12384748.468487417 11695849.560673947 1.0 0.6216082013335927 0.5870313819435007 24.24798378875574 -13.999999999999998 0.3385898754455214 5.339045846010057 0.5815069465600058 0.9997323812028973 0.0030601006004629303 19.574937084000386 0.1865639022275566 60.75011664559898 0.010736901404328958 1.0000000000000041e-14 13.999999999999998 -4.757538899450052 FFADLLDYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FFADLLDYIK 10 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 43536000.0 13133000.0 14770000.0 15633000.0 False True 17000927.390132464 13948036.516126525 12787954.408125706 1.0 0.8204279799596184 0.7521915784163623 24.01911011084819 -13.999999999999556 0.13414146383270062 1.854410870770379 0.6614735102334367 0.9996272848354383 0.0020177496790636297 11.932447329625376 0.11428459003629361 2.6788961860369636 0.0808231067393975 1.0000000000010225e-14 13.999999999999556 -1.1929373605369422 FFALPYVDHFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FFALPYVDHFLR 12 0 Q9HD33;Q9HD33-2;Q9HD33-3 Q9HD33 MRPL47 39S ribosomal protein L47, mitochondrial 0 18510560.0 7291900.0 7616860.0 3601800.0 False True 7060422.625884265 10658311.919400167 2658380.5283161374 1.0 1.509585542418616 0.376518612153645 22.751323112879916 -6.784439077164279 1.5183965722500228 1.2868874097940004 0.3662379571973087 0.7827960984892428 0.21594536759200525 0.24376309018301423 1.1102454777037647 0.11197961969480662 0.2632817113037884 1.6427100829047407e-07 6.784439077164279 -0.9206494525966917 down FFALPYVDHFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FFALPYVDHFLR 12 0 Q9HD33;Q9HD33-2;Q9HD33-3 Q9HD33 MRPL47 39S ribosomal protein L47, mitochondrial 0 36834000.0 11701000.0 13206000.0 11927000.0 False True 17751272.457684014 10849286.121051058 9569623.222210195 1.0 0.6111835727221185 0.5390950561444277 24.081419108693225 -13.999999999999998 0.2369912256449136 3.536584162277902 0.5062978622469776 0.9995200971647678 0.004434609666681703 13.519145757234307 0.1540952877296205 16.200803712890803 0.03585893495583755 1.0000000000000041e-14 13.999999999999998 -3.030286300030925 FFALPYVDHFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFALPYVDHFLR 12 0 Q9HD33;Q9HD33-2;Q9HD33-3 Q9HD33 MRPL47 39S ribosomal protein L47, mitochondrial 0 17774800.0 2694100.0 4747100.0 10333600.0 False True 3690181.5753149614 4537357.425439544 7893016.507172434 1.0 1.229575654431659 2.138923612857385 21.815260375138713 -6.945099742474369 0.6102763834123611 0.9899455484646649 2.425932259249769 0.9987584496139127 0.017328730090353944 0.085515156629661 0.04458010142953635 0.01760964820266111 0.07668603287584314 1.1347501727380288e-07 6.945099742474369 1.4359867107851043 up FFALPYVDHFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FFALPYVDHFLR 12 0 Q9HD33;Q9HD33-2;Q9HD33-3 Q9HD33 MRPL47 39S ribosomal protein L47, mitochondrial 0 23315100.0 7291900.0 12546600.0 3476600.0 False True 6063537.93594244 12479008.9754949 4203540.986017803 1.0 2.058040884270533 0.6932488970013275 22.531728388314193 -6.69983079455437 1.83241779734528 1.6571443810624134 0.6974445592826786 0.4163921238976107 0.4466289581560346 0.39584695213335497 2.584180267763474 0.19449944733127186 0.5001303566753093 1.9960398404492264e-07 6.69983079455437 -0.9596998217797348 FFALPYVDHFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FFALPYVDHFLR 12 0 Q9HD33;Q9HD33-2;Q9HD33-3 Q9HD33 MRPL47 39S ribosomal protein L47, mitochondrial 0 42079900.0 11701000.0 18466900.0 11912000.0 False True 15147175.16119243 17439200.781290244 9744138.227441514 1.0 1.1513170340810517 0.6432973887042861 23.852545430785675 -6.826883908585134 1.3416904934067109 1.0810477369003828 0.6304698120432473 0.8995003057280012 0.06751603882305843 0.18469892351361075 0.6513227522976988 0.039521406525261496 0.09097402835204346 1.48975925257446e-07 6.826883908585134 -0.45057792485713555 FFAPWCGHCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FFAPWCGHCK 10 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 13853500.0 5034500.0 2996600.0 5822400.0 False True 6600278.254167351 2549518.9606553162 5219953.900404546 1.0 0.38627446639019725 0.7908687633144434 22.654095416135473 -10.111842973288425 5.568830734902524 1.0000046590578542 0.5885716148523097 0.5796123742496739 0.16517493005104367 9.554613952880626e-06 1.523939317937313e-06 0.15993174894017317 0.05330997944151325 7.729600116917787e-11 10.111842973288425 -0.4114330442055445 FFAPWCGHCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFAPWCGHCK 10 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 14536300.0 5034500.0 5576100.0 3925700.0 False True 6895890.702246826 5329729.464303139 2998530.5123293735 1.0 0.772884851925887 0.43482860181533756 22.717305477658364 -6.9653850545405716 0.3513814284361469 1.0321541693276923 0.16412782425194786 0.9999208633746879 0.0020656793891330187 0.07783053966162803 0.01440060015906263 0.004624302973172132 0.029030439593196712 1.0829663077343632e-07 6.9653850545405716 -0.8680263450757445 down FFAPWCGHCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FFAPWCGHCK 10 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 13067000.0 4719700.0 3482000.0 4865300.0 False True 6109744.689195776 3288223.639076003 3979865.322193692 1.0 0.5381932971586789 0.6513963389061942 22.54268066404462 -9.978986977114007 7.0267064503414565 1.0000000271216563 0.5947948180324522 0.944700449204408 0.046214948268734464 1.9644870098212692e-08 2.846805067460883e-09 0.044747434581595386 0.014915810415886863 1.049573901021631e-10 9.978986977114007 -0.4052052090892041 FFCFQVLEHQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FFCFQVLEHQVK 12 0 O43592;F8WDU6 O43592 XPOT Exportin-T 0 17345000.0 6064200.0 5957300.0 5323500.0 False True 7950224.92579633 5068494.061373526 4772675.286617823 1.0 0.6375283855086457 0.6003195294678748 22.922564246669666 -13.999999999999998 0.3216806335767191 4.753913676212017 0.5930701889300386 0.999697322291431 0.0031364765035138014 18.144576352290834 0.18095145337734603 45.8815406436374 0.01230727257945007 1.0000000000000041e-14 13.999999999999998 -4.160843487281978 FFCFQVLEHQVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FFCFQVLEHQVK 12 0 O43592;F8WDU6 O43592 XPOT Exportin-T 0 15455600.0 7191900.0 0.0 8263700.0 False True 10910638.098317886 0.0 6630376.072891622 1.0 0.0 0.6076982861262569 23.37923214299117 -10.12043905845589 6.758785255384564 1.0000007905691068 0.3038491430631282 0.6363270774956622 0.24809178642886517 2.955766905221927e-06 3.8449182204472875e-07 0.2402141148744061 0.08007127976415332 7.578110637962199e-11 10.12043905845589 -0.6961516475059786 FFCFQVLEHQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFCFQVLEHQVK 12 0 O43592;F8WDU6 O43592 XPOT Exportin-T 0 18123500.0 6064200.0 5603400.0 6455900.0 False True 8306298.618843017 5355823.260034114 4931149.383434093 1.0 0.644790598773359 0.5936638699995296 22.985774308192557 -13.999999999999998 0.2730205699739669 3.786646864293593 0.5771837216955481 0.9995898577512503 0.0036596775562711833 15.033290171861681 0.1654348750188219 23.294154421287647 0.020918271777481706 1.0000000000000041e-14 13.999999999999998 -3.209463142598045 FFDEESYSLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FFDEESYSLLR 11 0 P51571;A6NLM8 P51571 SSR4 Translocon-associated protein subunit delta 0 4536500.0 1677000.0 2859500.0 0.0 False True 2198563.2400911017 2432873.746243701 0.0 1.0 1.106574376338108 0.0 21.068129600557306 -6.956806730696608 1.1920341247171913 1.0618139836172928 9.956018625303963e-20 0.9740034456620269 0.08036360724330685 0.1049129580501258 0.29575242938420193 0.056176822832361376 0.10617004173338244 1.1045700652272548e-07 6.956806730696608 -1.0618139836172928 down FFDEESYSLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFDEESYSLLR 11 0 P51571;A6NLM8 P51571 SSR4 Translocon-associated protein subunit delta 0 7828500.0 1677000.0 3107800.0 3043700.0 False True 2297032.2192209614 2970487.1198797235 2324840.746969183 1.0 1.2931847864489965 1.0121062854563063 21.131339662080197 -10.59863903339734 3.5191951066719307 0.9940956727991719 1.1526455359667265 0.2822457754312391 0.11474981756328256 83819273.19539459 21887.075289857956 4010560.6921081766 0.03928191177293029 2.5197703807177437e-11 10.59863903339734 0.1585498631675546 FFEHEVK(ub)LNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FFEHEVKLNK 10 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 4326200.0 1441500.0 1372000.0 1512700.0 True False 1889820.4595058563 1167302.9480141117 1356180.3148430123 1.0 0.6176792838401877 0.7176238927996481 20.849817748487865 -10.021625330891887 7.033252466813816 1.0000000436955838 0.6676515883199197 0.9364826269605661 0.040802215748779826 2.7961367537270748e-08 3.933972008760449e-09 0.039506580819071185 0.01316885850694874 9.514252413966216e-11 10.021625330891887 -0.33234845537566415 FFEHEVK(ub)LNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FFEHEVKLNK 10 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 10323500.0 1784400.0 8539100.0 0.0 True False 2707065.257114033 7015230.888707181 0.0 1.0 2.591452448466657 0.0 21.368298235222095 -6.741231555970815 1.6867811217668092 1.9462817660484966 6.7674567102814574e-09 0.6073330522783541 0.6686792133371615 0.3162470965191819 1.768056414119198 0.31381567125925375 0.7676723331232398 1.8145479289954506e-07 6.741231555970815 -1.9462817592810397 FFEHEVK(ub)LNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFEHEVKLNK 10 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 5181300.0 1441500.0 1422000.0 2317800.0 True False 1974461.5050727571 1359171.338074831 1770383.376589403 1.0 0.6883757088111712 0.8966411206503446 20.913027810010757 -10.255300069514856 4.979648851954203 1.0000406120428744 0.7925084158822134 0.5696043438986818 0.08502399834659316 3.834278644457714e-05 5.734015239321411e-06 0.08234022740753008 0.027441377468622286 5.5552029589500416e-11 10.255300069514856 -0.207532196160661 FFEHEVK(ub)LNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FFEHEVKLNK 10 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 5242000.0 0.0 2548200.0 2693800.0 True False 0.0 2534472.340821903 3257061.1252760664 0.0 FFEHEVK(ub)LNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FFEHEVKLNK 10 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 29347600.0 1784400.0 6860200.0 20703000.0 True False 2309940.9757825593 6478423.839399548 16935266.430718753 1.0 2.8045841462268513 7.331471500037546 21.139424557314545 -6.955388711539378 0.49617604277011623 0.9062569667893209 9.423780833261107 0.9995591009956083 0.055922133932810085 0.08139143683524332 0.027545899502432167 0.06606365572361972 0.37338795895090365 1.1081825020342432e-07 6.955388711539378 8.517523866471786 FFEHFIEGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FFEHFIEGGR 10 0 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8;F5H3F0;Q96FW1-2 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 2845570.0 989480.0 675990.0 1180100.0 False True 1297217.8621379512 575134.9269883822 1057994.57231853 1.0 0.44336032040177087 0.8155874222814384 20.306989363664098 -10.073680508893515 5.560226066858273 1.000002619829682 0.6294738713414914 0.5691837586218897 0.15196107800713873 4.9352932473792765e-06 8.21768572270424e-07 0.147136722367005 0.04904522703271644 8.439553898404012e-11 10.073680508893515 -0.37052874848819073 FFEHFIEGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFEHFIEGGR 10 0 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8;F5H3F0;Q96FW1-2 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 3899300.0 989480.0 996320.0 1913500.0 False True 1355317.4956915667 952299.2880103501 1461570.709769533 1.0 0.7026392642592045 1.0783972865514801 20.37019942518699 -6.6957644806862415 1.8457513179979006 0.8145927944998045 1.077203305734022 0.3976104425224186 0.12561915567057724 0.4043966106478174 2.6753143078788506 0.05435526110373138 0.14053447915018014 2.014816595254251e-07 6.6957644806862415 0.2626105112342175 FFEVILIDPFHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FFEVILIDPFHK 12 0 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 87422000.0 23151900.0 33029600.0 31240500.0 False True 35123124.93060885 27135209.818557348 25065801.481802452 1.0 0.7725739059997405 0.7136552209213675 25.06591787244848 -13.999999999880247 0.1896288560782387 2.217581513153312 0.6712281731768764 0.9994896139443123 0.0027892297211257206 12.344678469885984 0.13809385104977426 5.553111662651992 0.04063898820644973 1.0000000002757418e-14 13.999999999880247 -1.5463533399764353 FFEVILIDPFHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFEVILIDPFHK 12 0 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 37806300.0 18500000.0 5226300.0 14080000.0 False True 25339949.943701707 4995384.784937062 10754593.986702401 1.0 0.19713475346381554 0.4244125979173639 24.594910338806887 -10.283656523051974 5.098786455688358 1.0001534175811297 0.31077367570391096 0.9245944940153783 0.09278579145911191 0.0001618544929588058 2.2739436884073315e-05 0.0898591569588261 0.02994648542372617 5.2040741618674756e-11 10.283656523051974 -0.6893797418772187 FFEVILIDPFHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FFEVILIDPFHK 12 0 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 68785300.0 23151900.0 24586900.0 21046500.0 False True 29970590.9421768 23218617.40137788 17216252.95532638 1.0 0.7747133663855439 0.5744382214065193 24.83704419454093 -6.972515145505906 0.1886746913608504 1.1381086118934083 0.20557928466861108 0.9999959319833103 0.000350565640029449 0.0754946911903873 0.0060097293894668955 0.007151161263168116 0.02191299040724227 1.0653317108375417e-07 6.972515145505906 -0.9325293272247972 FFEVILIDPFHK(ub)AIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FFEVILIDPFHKAIR 15 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 14839000.0 3744800.0 1303400.0 9790800.0 True False 3625923.3737998884 1823854.4171412059 7226295.762295971 1.0 0.5030041258786576 1.9929532473056568 21.789917006428585 -6.816799217527121 1.3859123474174082 0.7312297479098472 2.023235270431494 0.8768023302106105 0.217406530639427 0.19767879402978178 0.7469604596939564 0.12330500976462717 0.28443544991335035 1.5247575148288924e-07 6.816799217527121 1.292005522521647 FFEVILIDPFHK(ub)AIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FFEVILIDPFHKAIR 15 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 67555700.0 6050700.0 19116000.0 42389000.0 True False 9179354.265422493 15704600.446010284 34010795.570241295 1.0 1.7108611337910333 3.7051403167165917 23.129961238122384 -6.952947499601197 0.5254886594571592 0.9674931934537473 4.538344994455266 0.9994127602022947 0.027748033600706476 0.0823233058383762 0.031227709662159275 0.0311672624326488 0.16482525975920875 1.1144292450512741e-07 6.952947499601197 3.5708518010015187 FFEVILIDPFHK(ub)AIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FFEVILIDPFHKAIR 15 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 12789600.0 3744800.0 2714600.0 6330200.0 True False 3113967.1227687243 2699975.9109940855 7653815.552462146 1.0 0.867053441654019 2.4578986388452626 21.57032228186286 -6.88660757716239 1.042219834971674 0.907442193004984 2.585977556686963 0.9786374697198894 0.10532858983668923 0.12193972688658627 0.23826051433807496 0.07732463425285163 0.1905652649534363 1.2983519149919368e-07 6.88660757716239 1.6785353636819789 up FFEVILIDPFHK(ub)AIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FFEVILIDPFHKAIR 15 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 64731800.0 6050700.0 9849100.0 48832000.0 True False 7832750.427128192 9300988.926945286 39945077.058631964 1.0 1.1874486508253794 5.0997510300194095 22.901087560214833 -6.916883895614004 0.847505442929687 0.9036084187255201 5.687563003442154 0.9932708917476641 0.15503959463448055 0.10004023114696584 0.11536747157545368 0.1314234793486673 0.38268180377067884 1.2109218183971006e-07 6.916883895614004 4.783954584716634 up FFGDSAASMAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FFGDSAASMAIK 12 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 32170300.0 13242000.0 9649400.0 9278900.0 False True 17360390.23571043 8209747.133066604 8318808.437493779 1.0 0.47290107086297534 0.47918326284981416 24.04929604199373 -9.81229302464667 6.459050874412678 1.0000000111644272 0.47604216685676987 0.9998921931451552 0.002564694139413977 4.1482367152461565e-10 7.447594152357503e-11 0.002483254496336882 0.000827751474110068 1.5406605966299001e-10 9.81229302464667 -0.5239578443076573 FFGDSAASMAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FFGDSAASMAIK 12 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 20961900.0 8310200.0 2635700.0 10016000.0 False True 8046397.2497735005 3688148.754993926 7392509.126440795 1.0 0.45836026242648464 0.91873529195304 22.93991153474618 -10.171703792596478 7.753778988151646 1.0000001177512983 0.6885477771897642 0.3789731618780957 0.1879473187764667 3.8256075630597545e-07 4.0918025185353534e-08 0.1819792793998446 0.06065973629879937 6.734358116988682e-11 10.171703792596478 -0.31145234056153404 FFGDSAASMAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFGDSAASMAIK 12 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 27234800.0 13242000.0 6763600.0 7229200.0 False True 18137925.251594514 6464761.78776577 5521811.850047516 1.0 0.3564223414801784 0.3044345906962038 24.112506103516623 -13.999999999999998 0.35659209719727303 9.244119335059779 0.29786650068236936 0.999767065102089 0.004828222576343336 21.334018560681972 0.19272145342049277 133.6389914359438 0.015171035290898902 1.0000000000000041e-14 13.999999999999998 -8.94625283437741 FFGDSAASMAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FFGDSAASMAIK 12 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 18451100.0 8310200.0 5999100.0 4141800.0 False True 6910299.504281304 5966781.657571887 5007831.230480514 1.0 0.8634620907350171 0.7246909091824301 22.720316810180456 -6.9709231298924115 0.2350963727592986 1.0529596072078413 0.5312037600616467 0.9999887114963922 0.00037758707125349586 0.07600429260925226 0.007950458778449257 0.0034355240299701667 0.013649969000228725 1.0692441186448042e-07 6.9709231298924115 -0.5217558471461946 FFGPLSSNTLHQVASYLCLLPTLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FFGPLSSNTLHQVASYLCLLPTLPK 25 0 O60306;H0YH15 O60306 AQR Intron-binding protein aquarius 0 1113060000.0 530840000.0 250990000.0 331230000.0 False True 805323089.6023402 206198873.5061793 265762245.31673366 1.0 0.25604490442214695 0.33000698570304765 29.584992456925743 -10.352603832783199 5.806750877238544 1.0001230651864566 0.2930259451041581 0.9918581677810898 0.030194893242083295 4.81147550287077e-05 5.364264820840167e-06 0.02924108866656857 0.009745359888924037 4.440134922331306e-11 10.352603832783199 -0.7070971200822984 FFGPLSSNTLHQVASYLCLLPTLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FFGPLSSNTLHQVASYLCLLPTLPK 25 0 O60306;H0YH15 O60306 AQR Intron-binding protein aquarius 0 1108260000.0 530840000.0 241860000.0 335560000.0 False True 687182844.4207667 228400278.38797325 274491523.1363566 1.0 0.3323719156296664 0.39944466798749645 29.356118779018193 -10.20340589657323 5.4120009015840465 1.000030973056746 0.3659082918186653 0.9916781452159406 0.02738233648709796 1.0233780735680692e-05 1.5063404317011913e-06 0.02651412433567894 0.008837611099520297 6.260284977996417e-11 10.20340589657323 -0.6341226812380807 FFHLAFEEEFGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FFHLAFEEEFGR 12 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 41937000.0 10794000.0 18924000.0 12219000.0 False True 16375287.14710203 15546864.346113125 9803909.294222057 1.0 0.9494101817240186 0.5987015193169957 23.96501686930852 -6.932861131130442 0.7229224735259306 1.004808425494038 0.52116037185546 0.997071248194936 0.00965729042806951 0.0911793339317305 0.07060059922998578 0.008953035010713942 0.031248892035063223 1.1671827727139472e-07 6.932861131130442 -0.4836480536385779 FFIINK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FFIINK 6 0 H3BU51;Q9UFM8;Q9Y639-3;Q9Y639-1;Q9Y639-4;Q9Y639-5;Q9Y639 H3BU51 NPTN;DKFZp566H1924 Neuroplastin 0 64382000.0 17434000.0 24282000.0 22666000.0 False True 22856142.831096187 20659220.250494678 20320739.747624606 1.0 0.9038804317580411 0.8890712618394159 24.446078621221066 -13.999999998789525 0.26330493806552163 1.7159331794072403 0.8838275299089057 0.9995691354978987 0.0010207190207492647 14.565703047609707 0.16239206508205262 5.559658907152206 0.006363559409632536 1.0000000027872223e-14 13.999999998789525 -0.8321056494983347 FFIINK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FFIINK 6 0 H3BU51;Q9UFM8;Q9Y639-3;Q9Y639-1;Q9Y639-4;Q9Y639-5;Q9Y639 H3BU51 NPTN;DKFZp566H1924 Neuroplastin 0 57081000.0 20363000.0 10172000.0 26546000.0 False True 19716587.71114264 14233732.646279225 19592806.237070385 1.0 0.7219166346028105 0.9937219626496373 24.2329065547619 -10.76991464016796 9.35594420891164 1.0010004027171922 0.8578192986641726 0.26731413400933945 0.11096406051408651 0.0023307266027276594 5.731809915056965e-05 0.108146487719615 0.03581349653321742 1.6985774721299825e-11 10.76991464016796 -0.14318110405301954 FFIINK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FFIINK 6 0 H3BU51;Q9UFM8;Q9Y639-3;Q9Y639-1;Q9Y639-4;Q9Y639-5;Q9Y639 H3BU51 NPTN;DKFZp566H1924 Neuroplastin 0 45618000.0 14975000.0 11772000.0 18871000.0 False True 22718169.819145195 9671194.624944182 15141138.57854687 1.0 0.42570306947851116 0.666477040143746 24.437343279899395 -10.313186405171097 5.753408105569761 1.0000507517234443 0.5460900548111323 0.8257444558483276 0.09829556191228753 6.399718789361449e-05 7.639464040791664e-06 0.09518486645543404 0.03172475619103112 4.86198477819458e-11 10.313186405171097 -0.453960696912312 FFIINK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFIINK 6 0 H3BU51;Q9UFM8;Q9Y639-3;Q9Y639-1;Q9Y639-4;Q9Y639-5;Q9Y639 H3BU51 NPTN;DKFZp566H1924 Neuroplastin 0 77405000.0 17434000.0 20742000.0 39229000.0 False True 23879820.93613493 19825549.85537844 29963918.146615624 1.0 0.8302218809931875 1.2547798506007322 24.509288682743957 -6.7982129255118755 1.4635050107480976 0.9061121236976408 1.2603646949961989 0.8267935737760518 0.07261487690900963 0.22332408599012113 0.9445567678394444 0.03903956995455911 0.090879913166249 1.5914282917054397e-07 6.7982129255118755 0.354252571298558 FFIINK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FFIINK 6 0 H3BU51;Q9UFM8;Q9Y639-3;Q9Y639-1;Q9Y639-4;Q9Y639-5;Q9Y639 H3BU51 NPTN;DKFZp566H1924 Neuroplastin 0 41502000.0 20363000.0 10746000.0 10393000.0 False True 16932736.73385478 10688109.165086009 12566128.248197384 1.0 0.6312097880619935 0.7421203344568077 24.013311830196177 -10.502576017581262 9.07683527598599 1.0000095713516692 0.6866650612594011 0.9141018338305322 0.04527904096009588 8.770389557107227e-06 4.806638349770442e-07 0.04384258039844896 0.014613747630891235 3.143576130123562e-11 10.502576017581262 -0.31334451009226816 FFIINK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FFIINK 6 0 H3BU51;Q9UFM8;Q9Y639-3;Q9Y639-1;Q9Y639-4;Q9Y639-5;Q9Y639 H3BU51 NPTN;DKFZp566H1924 Neuroplastin 0 37130400.0 14975000.0 15717000.0 6438400.0 False True 19385432.701380778 14842335.133646613 5266677.263562745 1.0 0.7656437368348982 0.27168221337600645 24.208469601991844 -6.959005810372619 0.4492268916410558 1.0160556986130422 0.001713384853206304 0.9997315272444894 0.00497395792037487 0.08005820688397164 0.022458191353452377 0.006594749378341166 0.04086349635502495 1.0989911360665156e-07 6.959005810372619 -1.014342313759836 down FFLQDPQSQELDVQVK(ub)DDSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FFLQDPQSQELDVQVKDDSR 20 1 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 15690500.0 3176900.0 2953500.0 9560100.0 True False 3076051.04844714 4132847.9522990314 7056023.01314762 1.0 1.3435563608040206 2.293857579739991 21.552648014994013 -6.953260156543097 0.5218266532249257 0.9840768397010429 2.695878345590556 0.9994329182821515 0.01303150795672404 0.08220244478617161 0.030744414526516828 0.01472047369043838 0.07850990326370429 1.1136272347514704e-07 6.953260156543097 1.7118015058895133 up FFLQDPQSQELDVQVK(ub)DDSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FFLQDPQSQELDVQVKDDSR 20 1 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 56873700.0 9932700.0 18476000.0 28465000.0 True False 15068632.077637635 15178813.44635312 22838880.273347292 1.0 1.0073119688733392 1.5156571715120029 23.845045120007114 -6.91003201068085 0.8955176663733146 0.9842764276379122 1.5813970239852826 0.990933572517333 0.022983491611130582 0.10439697854938756 0.1386529813575658 0.018819846446800757 0.05196276212524065 1.23017809434446e-07 6.91003201068085 0.5971205963473704 FFLSHPAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FFLSHPAYR 9 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3;K7EMQ3;Q9UQ16-3;E5RIK2;E5RHK8;Q9UQ16-2;Q9UQ16-5;Q9UQ16;Q9UQ16-4 P50570 DNM2;DNM3 Dynamin-2;Dynamin-3 0 5624600.0 1852700.0 2468700.0 1303200.0 False True 2428907.64157232 2100379.582917232 1168357.3651771108 1.0 0.8647424656944058 0.48102173387736996 21.211876202328472 -6.952700240029481 0.5283750267425019 1.006123330918324 0.3222700136270144 0.9993964701223542 0.005400201017332229 0.0824193683034081 0.03161350650405532 0.006039272200059092 0.03172508285148977 1.115063910619103e-07 6.952700240029481 -0.6838533172913095 down FFLSHPAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFLSHPAYR 9 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3;K7EMQ3;Q9UQ16-3;E5RIK2;E5RHK8;Q9UQ16-2;Q9UQ16-5;Q9UQ16;Q9UQ16-4 P50570 DNM2;DNM3 Dynamin-2;Dynamin-3 0 6597900.0 1852700.0 1925500.0 2819700.0 False True 2537693.257334926 1840425.0432229869 2153744.9335443694 1.0 0.7252354231164222 0.8487018386951236 21.275086263851364 -10.030944530124374 4.526670774817186 1.000008457944504 0.7869686309014946 0.7987696847698914 0.050404953145696 69756414.96130943 13663.451179066387 6359.274380283211 0.0172549561489816 9.312268079864651e-11 10.030944530124374 -0.2130398270430095 FFLSHPAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FFLSHPAYR 9 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3;K7EMQ3;Q9UQ16-3;E5RIK2;E5RHK8;Q9UQ16-2;Q9UQ16-5;Q9UQ16;Q9UQ16-4 P50570 DNM2;DNM3 Dynamin-2;Dynamin-3 0 3557460.0 879360.0 1498500.0 1179600.0 False True 731226.8022532312 1490427.2830710392 1426248.9061458323 1.0 2.0382558167703615 1.950487730688936 19.479959426081642 -10.21623068640969 5.262235089384017 0.9999253265449243 1.9943717737298976 0.994190928114199 0.03583117110091055 3.139320845361797e-05 4.675732873485516e-06 0.03469595842867156 0.011564460745617228 6.078120608923698e-11 10.21623068640969 0.9944464471849733 FFMGNQVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FFMGNQVLK 9 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 8165300.0 1987500.0 2578100.0 3599700.0 False True 2605631.7469773786 2193457.5293550882 3227237.574760624 1.0 0.8418140943744539 1.2385624248339504 21.31320177205204 -6.798501912579203 1.461930468306812 0.9125550334625994 1.2438444675326517 0.827772265250244 0.06767707895045695 0.22290272298766098 0.9406587398729855 0.0364204881701144 0.08478252298470988 1.5903696800156027e-07 6.798501912579203 0.3312894340700523 FFMGNQVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFMGNQVLK 9 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 8014300.0 1987500.0 2049400.0 3977400.0 False True 2722332.4601679547 1958850.731540477 3038020.037124298 1.0 0.719548681214206 1.1159621690500163 21.37641183357493 -6.716676367314526 1.7714874184916902 0.8287689999190518 1.1152220702279387 0.49665190875803966 0.1180660836619027 0.3618357142948483 2.2173291894240257 0.052959570264378586 0.13346016868422234 1.9200990497384427e-07 6.716676367314526 0.2864530703088869 FFPLESWQIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FFPLESWQIGK 11 0 P30046;J3KQ18;H7C342 P30046 DDT D-dopachrome decarboxylase 0 22627500.0 6088500.0 6918100.0 9620900.0 False True 7982082.461117876 5885946.446542583 8625421.55818942 1.0 0.737394843415119 1.0805979016384961 22.92833375241181 -6.702232611062394 1.8227190723847135 0.8372890879267705 1.0796259717525227 0.42819372527488375 0.11080472190366773 0.39093528257086 2.5265418978506453 0.04846725997252961 0.12431135699806023 1.9850314363134758e-07 6.702232611062394 0.24233688382575225 FFPLESWQIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFPLESWQIGK 11 0 P30046;J3KQ18;H7C342 P30046 DDT D-dopachrome decarboxylase 0 33740500.0 6088500.0 17261000.0 10391000.0 False True 8339582.985525836 16498351.94550611 7936859.80936255 1.0 1.9783185770967946 0.9517094347688306 22.9915438139347 -6.657075505079746 1.9831469905212458 1.6312371877015635 0.9559973254841557 0.22329863151798623 0.41683780170768675 0.4914145940188851 3.7120836256056537 0.16999506283579674 0.461985404152707 2.2025435024425278e-07 6.657075505079746 -0.6752398622174077 FFPLESWQIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FFPLESWQIGK 11 0 P30046;J3KQ18;H7C342 P30046 DDT D-dopachrome decarboxylase 0 12097000.0 8612700.0 0.0 3484300.0 False True 7161841.657303501 0.0 4212851.020417033 1.0 0.0 0.5882357111485218 22.771899191480475 -10.040854365228027 6.4311876252920595 1.0000004789461203 0.2941178555742551 0.6575337941203512 0.24014622346620035 1.6491056188886715e-06 2.4621081594395345e-07 0.2325207404048989 0.07750686034493004 9.10218450889261e-11 10.040854365228027 -0.7058826233718651 FFQEENTEK(ub)LK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FFQEENTEKLK 11 1 O00232;O00232-2 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 1 15335400.0 3254900.0 3933100.0 8147400.0 True False 4937921.265064151 3231207.5755494414 6537062.818867724 1.0 0.6543659572723995 1.3238491397417609 22.23547240227974 -6.766374356954404 1.5881806990937166 0.8008352461707775 1.3271223257407632 0.7165393615790059 0.1455415698783605 0.2723415293119579 1.355076573614228 0.07225542496540255 0.17258689829858995 1.712480532177234e-07 6.766374356954404 0.5262870795699857 FFQMVGLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 FFQMVGLK 8 0 B8ZZ19;P20472;H0Y3U0 B8ZZ19 PVALB Parvalbumin alpha 0 128234300.0 37985000.0 29168000.0 61081300.0 False True 49798702.847263254 24816248.095973525 54761193.00920242 1.0 0.49833121501351174 1.0996509924597742 25.56960482778615 -6.68533641636956 1.8832574121021015 0.6841201049591857 1.0974501505822 0.34862226290957055 0.21237555190216145 0.4267407837697805 2.9306875678256867 0.09034555201919596 0.23663499678979202 2.0637808754237443e-07 6.68533641636956 0.41333004562301434 FFQMVGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FFQMVGLK 8 0 B8ZZ19;P20472;H0Y3U0 B8ZZ19 PVALB Parvalbumin alpha 0 87861000.0 31299000.0 13323000.0 43239000.0 False True 30305430.37720638 18642943.37852716 31913408.75780486 1.0 0.6151684086476157 1.0530590841504064 24.853072995081696 -6.67460556738446 1.9209146299143023 0.7553414484259109 1.0513335372103765 0.29961448614675223 0.16329703825076156 0.450657270472364 3.2100814312522328 0.0683299335663613 0.18147989521537528 2.1154094134916765e-07 6.67460556738446 0.2959920887844656 FFQMVGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FFQMVGLK 8 0 B8ZZ19;P20472;H0Y3U0 B8ZZ19 PVALB Parvalbumin alpha 0 27976400.0 11359000.0 12576000.0 4041400.0 False True 17232433.454134908 10331714.54326352 3242615.518591451 1.0 0.5995505260915099 0.1881693335547678 24.038623108335013 -7.634419001070632 0.376664056552529 1.0522960995976771 3.7364310751836796e-18 0.9988435296657296 0.011271199653825047 0.12185544998696353 0.05351513284710922 0.025902525482427222 0.07326310909486772 2.3204969339660812e-08 7.634419001070632 -1.0522960995976771 down FFQMVGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FFQMVGLK 8 0 B8ZZ19;P20472;H0Y3U0 B8ZZ19 PVALB Parvalbumin alpha 0 115777300.0 37985000.0 31769000.0 46023300.0 False True 52029081.00602755 30365340.53396576 35153544.419616535 1.0 0.5836224654909423 0.6756518420062813 25.632814889309042 -10.548273626336076 6.658293682597374 1.0003638317144978 0.6296371537486196 0.9557411921617855 0.0375708356348423 0.00020310893980273015 1.37797806709327e-05 0.03641240489142792 0.012125935059736697 2.829608645011865e-11 10.548273626336076 -0.3707266779658782 FFQMVGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FFQMVGLK 8 0 B8ZZ19;P20472;H0Y3U0 B8ZZ19 PVALB Parvalbumin alpha 0 92089500.0 31299000.0 34220000.0 26570500.0 False True 26026505.280799534 34035650.0678618 32126268.70188868 1.0 1.3077303195589165 1.2343673633966181 24.633478270515972 -10.08169356288766 4.493466171772542 0.9999800857999945 1.271048841442076 0.9479176665679593 0.029950301486280324 20810210.640781086 0.16858840462245347 4362.5681751118 0.010252784822672539 8.2852656380678e-11 10.08169356288766 0.27106875564208144 FFQMVGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FFQMVGLK 8 0 B8ZZ19;P20472;H0Y3U0 B8ZZ19 PVALB Parvalbumin alpha 0 39226000.0 11359000.0 17859000.0 10008000.0 False True 14704449.419364557 16865130.950677283 8186646.690751738 1.0 1.1469406619514284 0.5567462240354674 23.809749430427463 -6.840808829218933 1.2787727805350846 1.078159312907522 0.5370385112822721 0.9258126603757348 0.06832872642156176 0.16785817148257406 0.5328748974842469 0.0418944317835396 0.09653097683513671 1.4427502916776463e-07 6.840808829218933 -0.5411208016252499 FFSDCK(ub)IQNGAQGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FFSDCKIQNGAQGIR 15 1 P31943;G8JLB6;E9PCY7;D6RBM0;D6RIU0;E7EN40;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;D6RDL0;D6RF17 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 37088800.0 8467400.0 19535000.0 9086400.0 True False 11100843.39841825 16620454.146833606 8146226.4909033915 1.0 1.4972244495586562 0.7338385200591282 23.404165955245634 -6.730932980709829 1.7199608596980291 1.2989133998424731 0.7342232482998079 0.563570871242487 0.20900542159971355 0.334469688579927 1.938872778780482 0.0962842832129539 0.2386588817240793 1.8580911691727778e-07 6.730932980709829 -0.5646901515426652 FFSDCK(ub)IQNGAQGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FFSDCKIQNGAQGIR 15 1 P31943;G8JLB6;E9PCY7;D6RBM0;D6RIU0;E7EN40;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;D6RDL0;D6RF17 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 20710700.0 11223000.0 6611500.0 2876200.0 True False 10866732.008159611 9251506.428517018 2122836.9358495376 1.0 0.8513605030077347 0.19535191760094406 23.373414802875974 -6.9426225104480395 0.6346997629882761 1.0071620113198452 0.00390936833469501 0.9984875871046707 0.013595350058350386 0.08659040887013798 0.04931299200331071 0.013513522862904864 0.05584175739449698 1.1412413256070984e-07 6.9426225104480395 -1.0032526429851503 down FFSDCK(ub)IQNGAQGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFSDCKIQNGAQGIR 15 1 P31943;G8JLB6;E9PCY7;D6RBM0;D6RIU0;E7EN40;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;D6RDL0;D6RF17 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 28579000.0 8467400.0 12385000.0 7726600.0 True False 11598026.602881083 11837789.748281866 5901736.214322065 1.0 1.0206727535304345 0.5088569302691551 23.467376016768526 -6.897487956930628 0.9770242730938208 1.0227708178626864 0.4577939895077297 0.9852741849798002 0.02870536861313222 0.11327762675186737 0.1880368832636539 0.02213565428245771 0.056899813713006946 1.2662283797802066e-07 6.897487956930628 -0.5649768283549568 FFSDCK(ub)IQNGAQGIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FFSDCKIQNGAQGIR 15 1 P31943;G8JLB6;E9PCY7;D6RBM0;D6RIU0;E7EN40;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;D6RDL0;D6RF17 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 24120500.0 11223000.0 5737500.0 7160000.0 True False 9332421.763200535 5706590.948695424 8657122.895900443 1.0 0.6114801809748428 0.9276394826085851 23.15382007831025 -9.944132555067434 6.60639765552425 1.000000024382485 0.7695598317917102 0.4146372178849219 0.12907149440623755 4.634943925982941e-08 7.469944072703803e-09 0.12497295104315727 0.04165764569211985 1.1372801129788776e-10 9.944132555067434 -0.23044019259077475 FFSDCK(ub)IQNGTSGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FFSDCKIQNGTSGIR 15 1 P55795 P55795 HNRNPH2 Heterogeneous nuclear ribonucleoprotein H2 1 44122000.0 12065000.0 14568000.0 17489000.0 True False 15817331.837626185 12394511.185619246 15679406.046333995 1.0 0.7836031584122961 0.9912800848646234 23.915002922096072 -10.63901345519228 8.329457365128642 1.0001108040904554 0.8874416216516927 0.28143772285353585 0.08478375019295202 0.00017462743103108805 7.568115656297957e-06 0.08217195747078003 0.02736383771052609 2.2960775105679873e-11 10.63901345519228 -0.11266918243876267 FFSDCK(ub)IQNGTSGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FFSDCKIQNGTSGIR 15 1 P55795 P55795 HNRNPH2 Heterogeneous nuclear ribonucleoprotein H2 1 18906200.0 8912300.0 6151200.0 3842700.0 True False 8629383.91484638 8607406.23808423 2836181.5914710443 1.0 0.9974531580725784 0.3286655941441602 23.040826132816075 -6.907734091490853 0.9110139639690459 1.0222203808797725 0.2462940014291812 0.9900382198276217 0.03152672779390857 0.10593622921091074 0.14703158244271855 0.025525529378098773 0.0694045094416335 1.2367044073084115e-07 6.907734091490853 -0.7759263794505913 down FFSDCK(ub)IQNGTSGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFSDCKIQNGTSGIR 15 1 P55795 P55795 HNRNPH2 Heterogeneous nuclear ribonucleoprotein H2 1 37076000.0 12065000.0 11372000.0 13639000.0 True False 16525756.544365456 10869547.437824897 10417749.10402231 1.0 0.6577337266614234 0.6303946857775958 23.978212983618963 -13.999999999999998 0.35823726829022157 5.4294248880839024 0.627019373277111 0.9997700833733155 0.002549812095072456 21.50739359130263 0.193289861139193 72.77461189668666 0.007934697992933181 1.0000000000000041e-14 13.999999999999998 -4.802405514806791 FFSDCK(ub)IQNGTSGIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FFSDCKIQNGTSGIR 15 1 P55795 P55795 HNRNPH2 Heterogeneous nuclear ribonucleoprotein H2 1 19476700.0 8912300.0 4203400.0 6361000.0 True False 7410972.331833924 4180755.4498904245 7691055.690059047 1.0 0.5641304895893265 1.037793064888668 22.821231408250352 -6.664787856989244 1.9556872385994672 0.7205450911082887 1.0358454401629478 0.25614024409809666 0.18537414904973665 0.47326138071088053 3.484399120945513 0.07644397526478502 0.20564955160743303 2.1637752207712745e-07 6.664787856989244 0.3153003490546591 FFSDCK(ub)IQNGTSGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FFSDCKIQNGTSGIR 15 1 P55795 P55795 HNRNPH2 Heterogeneous nuclear ribonucleoprotein H2 1 77988000.0 13227000.0 14068000.0 50693000.0 True False 17122612.243149463 13285103.433234135 41467394.154104486 1.0 0.7758806451129753 2.421791346159524 24.029399481765235 -6.872514934080123 1.1206455163724578 0.8710847120007545 2.5229314807548815 0.9671323434042629 0.13213284185482288 0.1344694191389635 0.31408419088869344 0.09135543148423868 0.2172934336386925 1.341173815681467e-07 6.872514934080123 1.651846768754127 up FFSTLYENCFHILGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FFSTLYENCFHILGK 15 0 Q9HAV4 Q9HAV4 XPO5 Exportin-5 0 3607780.0 929580.0 1350900.0 1327300.0 False True 1218688.3820655246 1149350.9857669563 1189963.7283606336 1.0 0.9431049008762601 0.9764298617041001 20.21689784612629 -10.07763249489288 4.8897258576173535 1.0000012429511371 0.9597673812898504 0.6602536266503541 0.013604858288879699 1.843498621364381e-07 3.47664209968288e-08 0.013173254315359605 0.004390949131532902 8.363104146110895e-11 10.07763249489288 -0.04023386166128673 FFSTLYENCFHILGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFSTLYENCFHILGK 15 0 Q9HAV4 Q9HAV4 XPO5 Exportin-5 0 9789780.0 929580.0 2728900.0 6131300.0 False True 1273270.846954931 2608328.174734463 4683213.218087242 1.0 2.04852579557002 3.6780966353602613 20.28010790764918 -6.9646610757117475 0.36382191416677845 0.8655704310941897 4.9172288479752595 0.9999059879813998 0.010683732596163632 0.0780761557430463 0.015266599491639254 0.021702471199303925 0.13887433553150658 1.084773142924122e-07 6.9646610757117475 4.05165841688107 FFTGSLAEVEK(ub)SNSQVVEEQSYLLNIAEVQAVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSR 34 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 171652000.0 58531000.0 71894000.0 41227000.0 True False 88795806.18927461 59063953.98961418 33078465.37956402 1.0 0.6651660311942564 0.3725228341196082 26.40398820415614 -7.391086798092079 0.2266785314821454 1.1517368589027719 4.7267176483830406e-11 0.9999430593181853 0.0019344552899336121 0.1180635880998815 0.017595578481165705 0.022203053919778306 0.05565340027643255 4.063621055212715e-08 7.391086798092079 -1.1517368588555048 down FFTGSLAEVEK(ub)SNSQVVEEQSYLLNIAEVQAVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FFTGSLAEVEKSNSQVVEEQSYLLNIAEVQAVSR 34 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 118854000.0 58531000.0 23495000.0 36828000.0 True False 75769533.31849872 22187482.5962351 30125681.887190774 1.0 0.2928285502692696 0.3975962443975586 26.17511452624859 -10.02949497576698 5.442495176538301 1.0000034208298483 0.34521239734329984 0.9811611031245748 0.04277123202612206 1.7753089803937875e-06 3.165770313960613e-07 0.04141328324034233 0.013804355777480064 9.343401773184763e-11 10.02949497576698 -0.6547910234865484 FFTSSTSLTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FFTSSTSLTLK 11 0 Q99567;J3KMX1;I3L245 Q99567 NUP88 Nuclear pore complex protein Nup88 0 46279000.0 12805000.0 19346000.0 14128000.0 False True 16576324.92428587 18269378.09349926 11556848.965521656 1.0 1.1021368232673159 0.6971900598177699 23.982620851913165 -6.8398846775686355 1.2830827490305794 1.0543329962358075 0.6839140449080736 0.924230257249197 0.04733205345294311 0.16893531843545362 0.5403220872908798 0.0289278614112069 0.06663645919046998 1.4458236433698792e-07 6.8398846775686355 -0.37041895132773384 FFVGGNWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FFVGGNWK 8 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 146592200.0 51503200.0 45793400.0 49295600.0 False True 67521193.95769821 38961203.22127517 44194964.18878513 1.0 0.5770218347395372 0.654534696416552 26.008837079240354 -10.799297065939305 7.171421790142685 1.0139719342570228 0.6157782655780446 0.9703798844506878 0.031644493268603205 0.006956063504964512 0.0001946755802318051 0.030149875018106963 0.010213216285706074 1.58746052302284e-11 10.799297065939305 -0.3981936686789782 FFVGGNWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FFVGGNWK 8 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 98028000.0 37903000.0 10890000.0 49235000.0 False True 36699790.01205321 15238433.790599765 36338876.48166058 1.0 0.4152185553539966 0.9901657875896813 25.129268472526995 -10.887949987883234 11.078204595681806 1.017056636167908 0.7026921715047846 0.26282472175139004 0.23472122466714793 0.08792565743264566 0.0008893186273884889 0.20208606642852361 0.07575594951143945 1.2943448859421036e-11 10.887949987883234 -0.3143644646631235 FFVGGNWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FFVGGNWK 8 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 115036000.0 35721000.0 40479000.0 38836000.0 False True 54191368.554903865 33255206.186129496 31160047.577576544 1.0 0.6136624165975262 0.5750001966827395 25.69155974577803 -13.999999999999998 0.3253724722449368 5.090268219232465 0.5677765298209094 0.9997051566825309 0.0032948410194301608 18.440266671573593 0.1821688083574095 51.490995093096636 0.012607832872824005 1.0000000000000041e-14 13.999999999999998 -4.522491689411556 FFVGGNWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFVGGNWK 8 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 110576200.0 51503200.0 34389000.0 24684000.0 False True 70545324.86164632 32869580.270784404 18854147.58293766 1.0 0.46593562840979624 0.26726289261427977 26.072047140763246 -13.999999999999998 0.13732613537636498 3.545758025966045 0.01329062942325212 0.9996138063134766 0.00608042306090077 11.93222658952532 0.11590173841990618 8.15312615561916 0.22666463869523618 1.0000000000000041e-14 13.999999999999998 -3.532467396542793 FFVGGNWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FFVGGNWK 8 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 77437000.0 37903000.0 27631000.0 11903000.0 False True 31518023.887604862 27482146.318675898 14391862.266746225 1.0 0.8719501710094154 0.4566232425633173 24.90967374796127 -6.949684778119676 0.5622980192434168 1.0053679986270756 0.30327797625196773 0.9991762816194945 0.006656694237286556 0.08361265377913404 0.0364887693445843 0.007115952405790861 0.034542390437166864 1.1228331391975492e-07 6.949684778119676 -0.7020900223751079 down FFVGGNWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FFVGGNWK 8 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 238496000.0 35721000.0 99125000.0 103650000.0 False True 46241538.66617847 93608606.61212207 84786763.5388107 1.0 2.024340221200043 1.8335627659558091 25.46268606787048 -10.229181886105604 4.76257158708363 0.9998018857059779 1.9289514935798238 0.969337722610177 0.07788456997167478 54907808.95150664 41.94337300672935 119291.16606893436 0.026661959908041793 5.899539508524441e-11 10.229181886105604 0.9291496078738458 FFVMGITSYGHGCGRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FFVMGITSYGHGCGRR 16 1 Q86WS5 Q86WS5 TMPRSS12 Transmembrane protease serine 12 0 7765300.0 2673800.0 2758700.0 2332800.0 False True 3505377.6931160283 2347112.7133283764 2091424.2337977025 1.0 0.6695748415178514 0.5966330640789173 21.741138467662505 -13.999999999999998 0.21229278608690574 2.9292052960225528 0.5546133096185952 0.9994914219650013 0.003957842720931669 12.80134339724416 0.14602269631460046 10.312579681545252 0.04252341829185194 1.0000000000000041e-14 13.999999999999998 -2.3745919864039573 FFVMGITSYGHGCGRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFVMGITSYGHGCGRR 16 1 Q86WS5 Q86WS5 TMPRSS12 Transmembrane protease serine 12 0 7306800.0 2673800.0 2328700.0 2304300.0 False True 3662376.116728085 2225810.3340188907 1760071.798548176 1.0 0.6077503410565592 0.48058193436467667 21.804348529185397 -13.999999999999998 0.15752934499359084 2.922031668499566 0.35209747735818797 0.9995430859870728 0.0047253770488306914 11.994165885579207 0.12533847643374163 7.045506082621022 0.1167500896187824 1.0000000000000041e-14 13.999999999999998 -2.569934191141378 FFVMGITSYGHGCGRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FFVMGITSYGHGCGRR 16 1 Q86WS5 Q86WS5 TMPRSS12 Transmembrane protease serine 12 0 10781700.0 1907500.0 2683400.0 6190800.0 False True 2469296.352446334 2534066.431101825 5064137.922972208 1.0 1.0262301762975203 2.050842507403035 21.235668561150227 -6.912399662247953 0.8792519653757954 0.9706314262795683 2.1902763161417904 0.991795431240432 0.04432093750331292 0.10285285454251086 0.1303254027537276 0.03672203536543247 0.1031342929047177 1.2234897568378891e-07 6.912399662247953 1.219644889862222 up FFVTTLPAFFHAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFVTTLPAFFHAK 13 0 Q9H1E5 Q9H1E5 TMX4 Thioredoxin-related transmembrane protein 4 0 3519580.0 526080.0 1755000.0 1238500.0 False True 720585.9927774377 1677458.2969910915 945991.8077081612 1.0 2.327908554710411 1.3128090431815305 19.45881108242281 -10.1595762503374 4.61761488409041 0.9998931105557525 1.8203587989558212 0.4654754821104157 0.4144126402685446 49679688.29213881 109304268.59062627 34189.58654619076 0.14186446588903787 6.925063334247298e-11 10.1595762503374 0.8204656884000687 FFWHLTLPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 FFWHLTLPER 10 0 P55212;D6RHU3;D6RBM3 P55212 CASP6 Caspase-6;Caspase-6 subunit p18;Caspase-6 subunit p11 0 3596700.0 1021100.0 1449200.0 1126400.0 False True 1338671.9883464677 1232985.0089373551 1009850.9331917574 1.0 0.9210508770414644 0.7543677181436572 20.352371073110177 -6.958972144860666 0.4496856746956935 1.0053924849947222 0.6634217465656143 0.9997301538637382 0.0016819326285175528 0.08007035135242285 0.022503553744621745 0.002226849681646054 0.013788090169833669 1.0990763306402678e-07 6.958972144860666 -0.34197073842910797 FFWHLTLPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFWHLTLPER 10 0 P55212;D6RHU3;D6RBM3 P55212 CASP6 Caspase-6;Caspase-6 subunit p18;Caspase-6 subunit p11 0 4769700.0 1021100.0 1597200.0 2151400.0 False True 1398628.264189938 1526630.42276591 1643283.6294738331 1.0 1.0915197853877983 1.1749252260575438 20.41558113463307 -6.972232740546775 0.19771154271002878 0.9488652144060015 1.3198769467351334 0.9999949555278871 0.00016034633511175707 0.07558473635619212 0.006365966245256795 0.002759600824009616 0.008906463955363538 1.0660246802608163e-07 6.972232740546775 0.371011732329132 FFWHLTLPER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FFWHLTLPER 10 0 P55212;D6RHU3;D6RBM3 P55212 CASP6 Caspase-6;Caspase-6 subunit p18;Caspase-6 subunit p11 0 7122200.0 1649500.0 3499400.0 1973300.0 False True 2135310.2665060135 3304655.313780171 1614179.6477678288 1.0 1.5476230155477801 0.755946184068648 21.026014281993263 -6.72070337829233 1.7576336050640753 1.3329344068717521 0.7572026183598082 0.5154665336395647 0.23042220647512082 0.35394466724542567 2.137476326652719 0.10409763165286376 0.2610242443409385 1.902377153670161e-07 6.72070337829233 -0.575731788511944 FFYLLEPGVPAGTCPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FFYLLEPGVPAGTCPK 16 0 Q9Y5Y6 Q9Y5Y6 ST14 Suppressor of tumorigenicity 14 protein 0 5144100.0 1651000.0 1567400.0 1925700.0 False True 2164476.9883067408 1333550.029677348 1726447.036618754 1.0 0.6161072799025585 0.7976278084477787 21.045587031906216 -10.109508107178854 5.168928096966139 1.0000073143433166 0.7068675441747404 0.7766402789291523 0.0741054454641761 6.24650773135211e-06 1.0761904697056284e-06 0.07175407887270992 0.02391742967862162 7.77126811667472e-11 10.109508107178854 -0.2931397701685762 FFYLLEPGVPAGTCPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FFYLLEPGVPAGTCPK 16 0 Q9Y5Y6 Q9Y5Y6 ST14 Suppressor of tumorigenicity 14 protein 0 6544100.0 1651000.0 2172600.0 2720500.0 False True 2261419.3165973774 2076607.3481725613 2077973.930456242 1.0 0.9182761166545214 0.9188804195689128 21.108797093429107 -10.187116476565357 5.474356687672399 1.0000028888558208 0.9185782681117071 0.9999586657745827 0.0002467056317579712 8.698793953694469e-09 1.2914029764821983e-09 0.00023888017584519606 7.962390026272242e-05 6.49955350758244e-11 10.187116476565357 -0.08142462074411372 FFYSDQNVDSRDPVQLNLLYVQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FFYSDQNVDSRDPVQLNLLYVQAR 24 1 Q9Y490;Q9Y4G6 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 7767400.0 2856500.0 1477200.0 3433700.0 False True 2765821.971069047 2067053.6634962321 2534310.96120804 1.0 0.7473560066837105 0.9162957658581606 21.39927686618794 -10.176652457393281 4.68761309249424 1.0000232393720812 0.8318258862696809 0.5692023095569676 0.06896936787864572 96745989.31223457 1.5670293361547134 24267.494999477523 0.02361004910185859 6.658057517423298e-11 10.176652457393281 -0.16819735310240025 FFYSDQNVDSRDPVQLNLLYVQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FFYSDQNVDSRDPVQLNLLYVQAR 24 1 Q9Y490;Q9Y4G6 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 42366200.0 9538200.0 19950000.0 12878000.0 False True 14470146.735824406 16389766.62993855 10332657.65537208 1.0 1.1326607068442267 0.7140672340102153 23.78657621593417 -6.821478033503758 1.3654636311758015 1.0713980425237386 0.7046354801871691 0.8877525446686566 0.05851928328627368 0.19156562978533606 0.7014174770375078 0.0336744524265455 0.07758540665646245 1.5084189040270661e-07 6.821478033503758 -0.36676256233656945 FFYSDQNVDSRDPVQLNLLYVQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FFYSDQNVDSRDPVQLNLLYVQAR 24 1 Q9Y490;Q9Y4G6 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 6782700.0 2856500.0 1850000.0 2076200.0 False True 2375306.3144063368 1840033.682803751 2510323.820735823 1.0 0.7746511141084693 1.0568421451627519 21.179682141622216 -6.694024443590387 1.852258718087061 0.8592564481741913 1.0559133681322557 0.38928287789032556 0.09523027389924625 0.4080628685919865 2.717421138585514 0.041084083359516 0.10644065157040224 2.0229053193900888e-07 6.694024443590387 0.19665691995806434 FFYSDQNVDSRDPVQLNLLYVQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FFYSDQNVDSRDPVQLNLLYVQAR 24 1 Q9Y490;Q9Y4G6 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 31286000.0 9538200.0 14977000.0 6770800.0 False True 12347387.926030714 14143516.784158893 5538583.874274765 1.0 1.145466301770724 0.4485632027967911 23.557702538026618 -6.8522200799496815 1.2242218751340175 1.0778048874455668 0.4194713546901301 0.9434832823882666 0.07136009003142019 0.15503650589172638 0.44599931200497467 0.04558253018119611 0.10564834996030613 1.405335186098988e-07 6.8522200799496815 -0.6583335327554367 down FGAILAQGILDAGGHNVTISLQSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGAILAQGILDAGGHNVTISLQSR 24 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 355780000.0 113200000.0 116490000.0 126090000.0 False True 171732676.02852973 95701449.35947572 101168256.23278964 1.0 0.5572698892992092 0.5891031256974222 27.35558932994249 -9.963399689713572 5.457787547348448 1.0000009390611329 0.5731865074973621 0.9958453108012008 0.012995864342854782 1.4850371840210904e-07 2.8205861213950077e-08 0.012583219289744055 0.004194397180301627 1.0879283906653122e-10 9.963399689713572 -0.42681443156377075 FGAILAQGILDAGGHNVTISLQSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGAILAQGILDAGGHNVTISLQSR 24 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 187174000.0 113200000.0 15935000.0 58039000.0 False True 146539631.50559607 15048203.242009215 47476497.530429706 1.0 0.10269033085042631 0.3239840106232058 27.12671565203494 -10.388320433020098 5.06879177593327 1.000624183468022 0.21333717073674446 0.9439749203355841 0.09034276645794663 0.0006377241803770729 7.695776643180095e-05 0.08753870390647916 0.029158002495124992 4.0895880864234493e-11 10.388320433020098 -0.7872870127312777 FGALTAEK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGALTAEKLR 10 1 O95372;Q5QPQ0 O95372 LYPLA2 Acyl-protein thioesterase 2 1 3979470.0 1075300.0 934270.0 1969900.0 True False 1409728.7132200133 794880.5577559362 1766073.644615095 1.0 0.5638535629598692 1.2527755362101842 20.426986127871285 -6.735656251334273 1.7029549542452702 0.7391926901849162 1.2527813527305116 0.5851462652066344 0.1832780129421867 0.3257261179822907 1.853074287124719 0.08520816397359272 0.2100697767254769 1.8379925582662092e-07 6.735656251334273 0.5135886625455954 FGALTAEK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGALTAEKLR 10 1 O95372;Q5QPQ0 O95372 LYPLA2 Acyl-protein thioesterase 2 1 4682400.0 1075300.0 1724300.0 1882800.0 True False 1472867.468889863 1648114.7245024159 1438121.4174831882 1.0 1.1189837234606324 0.9764092478511568 20.490196189394176 -6.6852711848808815 1.8832904233329326 1.0749243501668593 0.9769293763001594 0.3483267348257376 0.05037125308361661 0.4269304603370783 2.931987597347612 0.021427150082590846 0.05613119846858487 2.0640908807662515e-07 6.6852711848808815 -0.09799497386669986 FGALTAEK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGALTAEKLR 10 1 O95372;Q5QPQ0 O95372 LYPLA2 Acyl-protein thioesterase 2 1 6115900.0 1509800.0 1789600.0 2816500.0 True False 1255465.5954807226 1779959.0695922144 3405417.127975364 1.0 1.4177680981458207 2.712473476161979 20.259791063159046 -6.950718115358674 0.5509073992501532 0.9821901509944299 3.2089691014423694 0.9992564136443124 0.019879747233485935 0.08319873975219769 0.034779411341674414 0.021551931593392575 0.10742520380989326 1.1201647054469739e-07 6.950718115358674 2.2267789504479394 up FGALTAEK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGALTAEKLR 10 1 O95372;Q5QPQ0 O95372 LYPLA2 Acyl-protein thioesterase 2 1 21306600.0 1973600.0 3387000.0 15946000.0 True False 2554864.1054721233 3198510.4725877116 13043991.619776914 1.0 1.2519297859079852 5.105552029886327 21.284815124841092 -6.920188447418302 0.823333077417348 0.9155486962349223 5.729674414140019 0.9942330037028725 0.1426784215090159 0.09806098696002596 0.10504231611222589 0.12305481897566108 0.3692714172274786 1.2017428657498559e-07 6.920188447418302 4.814125717905097 up FGANAILGVSLAVCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGANAILGVSLAVCK 15 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;E5RI09;E5RG95;P06733-2;P13929;P13929-3;P13929-2;E5RGZ4;K7EPM1;K7EKN2;P09104;P09104-2 P06733;P06733-2;P13929;P09104 ENO1;ENO3;ENO2 Alpha-enolase;Enolase;Beta-enolase;Gamma-enolase 0 8568800.0 3387500.0 4092100.0 1089200.0 False True 4441045.304596669 3481574.630880871 976500.0323441599 1.0 0.7839538649329459 0.21988067343817483 22.082467858121557 -7.0087856069648025 0.5261554695983824 1.0085704065476662 2.704656210868501e-14 0.999480749460635 0.00749414059032216 0.07522684585804336 0.030029311349794505 0.008594805914646557 0.042491072103416516 9.799736380482853e-08 7.0087856069648025 -1.008570406547639 down FGANAILGVSLAVCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGANAILGVSLAVCK 15 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;E5RI09;E5RG95;P06733-2;P13929;P13929-3;P13929-2;E5RGZ4;K7EPM1;K7EKN2;P09104;P09104-2 P06733;P06733-2;P13929;P09104 ENO1;ENO3;ENO2 Alpha-enolase;Enolase;Beta-enolase;Gamma-enolase 0 49155000.0 31582000.0 11904000.0 5669000.0 False True 30579446.697112817 16657329.278539933 4184118.833645453 1.0 0.5447230436681724 0.1368278136321054 24.866058967098837 -7.869230512398186 0.397741038056943 1.0548303239247865 1.5511872124108013e-25 0.9978404175248088 0.01638417868385867 0.1082697577434766 0.07659505455645291 0.038180602398667426 0.08052473986909697 1.3513551080950663e-08 7.869230512398186 -1.0548303239247865 down FGANAILGVSLAVCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGANAILGVSLAVCK 15 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;E5RI09;E5RG95;P06733-2;P13929;P13929-3;P13929-2;E5RGZ4;K7EPM1;K7EKN2;P09104;P09104-2 P06733;P06733-2;P13929;P09104 ENO1;ENO3;ENO2 Alpha-enolase;Enolase;Beta-enolase;Gamma-enolase 0 1705213640.0 437945200.0 623857800.0 643410640.0 False True 664394886.4827722 512525501.3667613 516240244.98709834 1.0 0.771416986786293 0.7770081550747824 29.307465728735227 -10.120261630514223 4.775351141794466 1.0000142115009962 0.7742125709285277 0.9995403048020443 0.0022825849023844244 3184127.6050985167 0.056464588809077176 497.56703383529515 0.0007813895242443061 7.581207254020329e-11 10.120261630514223 -0.22580164057246854 FGANAILGVSLAVCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGANAILGVSLAVCK 15 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;E5RI09;E5RG95;P06733-2;P13929;P13929-3;P13929-2;E5RGZ4;K7EPM1;K7EKN2;P09104;P09104-2 P06733;P06733-2;P13929;P09104 ENO1;ENO3;ENO2 Alpha-enolase;Enolase;Beta-enolase;Gamma-enolase 0 6706900.0 3387500.0 1300600.0 2018800.0 False True 4639950.293745387 1243135.1914909473 1542001.0184911082 1.0 0.267919937238699 0.3323313658272831 22.14567791964445 -10.097573682338096 4.992995856558625 1.0000218378163 0.3001256515302187 0.9936875659932389 0.026295855617235936 73199162.71803331 0.7048620255299847 18377.796518196417 0.009001770805078671 7.987784095427537e-11 10.097573682338096 -0.6998961862860813 FGANAILGVSLAVCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGANAILGVSLAVCK 15 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;E5RI09;E5RG95;P06733-2;P13929;P13929-3;P13929-2;E5RGZ4;K7EPM1;K7EKN2;P09104;P09104-2 P06733;P06733-2;P13929;P09104 ENO1;ENO3;ENO2 Alpha-enolase;Enolase;Beta-enolase;Gamma-enolase 0 44751300.0 31582000.0 5359300.0 7810000.0 False True 26261832.319825318 5330428.387162236 9443034.890640011 1.0 0.20297244770458162 0.359572583346036 24.646464242533114 -10.082847476029634 7.384440870061064 1.000000121312617 0.2812725157751473 0.9656186692019749 0.06393173766203292 1.2770991700508094e-07 1.586384666811876e-08 0.06190164896099099 0.020633879604929576 8.263281045745223e-11 10.082847476029634 -0.7187276055374698 FGANAILGVSLAVCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGANAILGVSLAVCK 15 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;E5RI09;E5RG95;P06733-2;P13929;P13929-3;P13929-2;E5RGZ4;K7EPM1;K7EKN2;P09104;P09104-2 P06733;P06733-2;P13929;P09104 ENO1;ENO3;ENO2 Alpha-enolase;Enolase;Beta-enolase;Gamma-enolase 0 1249561490.0 437945200.0 466908200.0 344708090.0 False True 566928694.590501 440924348.2247058 281974754.6236866 1.0 0.7777421612839521 0.4973725220018369 29.078592050827677 -6.9679753002810125 0.3026656479461738 1.0471105102379077 0.21918555855944566 0.9999620030296773 0.0012676693046766328 0.07696530049638958 0.011369194933675004 0.004591022554387254 0.025075007146967237 1.0765264373973063e-07 6.9679753002810125 -0.827924951678462 down FGANAILGVSLAVCK(ub)AGAVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGANAILGVSLAVCKAGAVEK 21 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 1 19182600.0 9460200.0 3706300.0 6016100.0 True False 9159891.129251683 5186244.918099163 4440302.93086865 1.0 0.5661906724564807 0.4847549897933558 23.126899020460574 -13.999999999999982 0.23523082496423958 3.806477610907705 0.44708071890726564 0.9995173662109834 0.004968298387862547 13.459866245799075 0.15353238691480098 17.695485515178767 0.040939040596808245 1.0000000000000409e-14 13.999999999999982 -3.359396892000439 FGANAILGVSLAVCK(ub)AGAVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGANAILGVSLAVCKAGAVEK 21 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 1 97707000.0 22938000.0 32045000.0 42724000.0 True False 34798622.99242416 26326319.38127223 34279582.673405536 1.0 0.7565333659036912 0.9850844581082526 25.052526882891687 -10.525033017638451 8.108365359326038 1.0000181981285894 0.8708089120493187 0.2987510634540218 0.09330559267616091 3.069942871117819e-05 1.7984185003845375e-06 0.09035546722473685 0.030114250545231987 2.985155661078973e-11 10.525033017638451 -0.12920928607927074 FGANAILGVSLAVCK(ub)AGAVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGANAILGVSLAVCKAGAVEK 21 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 1 75637000.0 22938000.0 33206000.0 19493000.0 True False 29693693.175577406 31358056.909580067 15945474.015070299 1.0 1.056051085466579 0.5369986791735694 24.823653204984137 -6.8801658664626375 1.078931064913446 1.0348112356622845 0.500104969787077 0.973816511380149 0.03763783022482921 0.12748060934035998 0.27143045660293813 0.026869280869409828 0.06500114337086596 1.3177533639061682e-07 6.8801658664626375 -0.5347062658752075 FGAPPHAGGGIGLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGAPPHAGGGIGLER 15 0 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 12876400.0 2411400.0 4608900.0 5856100.0 False True 3161368.7520308155 3921270.0853514946 5250166.947677771 1.0 1.240370988937159 1.660725894220705 21.592117894885497 -6.962582430358253 0.39736610694138064 0.9762104606900046 1.940170084862829 0.9998543131754563 0.0032958000636702563 0.07879119757746776 0.017814898520850067 0.0054113142208079435 0.03525408043337725 1.0899775918273254e-07 6.962582430358253 0.9639596241728243 FGAPPHAGGGIGLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGAPPHAGGGIGLER 15 0 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 7286950.0 2087900.0 772450.0 4426600.0 False True 2021620.7573586765 1080893.3132735337 3267140.6648465237 1.0 0.5346667070661469 1.6160996828679013 20.947080951929177 -6.789767406803517 1.4971746964465187 0.7398403988136054 1.6275411184110768 0.8005801227048102 0.19779281062341458 0.23570704701856146 1.043755356108231 0.10398549708046144 0.24350598757711034 1.6226789157343822e-07 6.789767406803517 0.8877007195974714 FGAPPHAGGGIGLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGAPPHAGGGIGLER 15 0 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 9578900.0 2411400.0 2402900.0 4764600.0 False True 3302959.7456347174 2296731.9326723027 3639299.6100172037 1.0 0.6953557141311597 1.1018298405928206 21.65532795640839 -6.706136908360226 1.8091316928091772 0.8119759807952056 1.1007643335578985 0.44668932155742214 0.12845572156406676 0.3828822033725954 2.4403604873136273 0.05655888012508278 0.14435484979289326 1.9672660248075568e-07 6.706136908360226 0.2887883527626929 FGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGAPPHAGGGIGLERVTMLFLGLHNVRQTSMFPR 34 2 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 51362000.0 14403000.0 16901000.0 20058000.0 False True 11976732.661086824 16809950.958414175 24252035.0622865 1.0 1.4035506539300813 2.024929147920528 23.51373104841802 -6.9648188780195115 0.36115231087695554 0.9471557276025169 2.502655995870461 0.9999093567755364 0.004013566888755644 0.07802253416689559 0.015077338345316736 0.008317545158835041 0.05303717193227364 1.0843790586865796e-07 6.9648188780195115 1.5555002682679442 up FGAQNEEMLPSILVLLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGAQNEEMLPSILVLLKR 18 1 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 1 14031400.0 4373800.0 5910500.0 3747100.0 True False 5661970.320487427 5581575.47925294 3065166.248492789 1.0 0.9858009073372244 0.5413603524910239 22.432872756116787 -6.913703539773389 0.8701249443014103 1.0122019294322198 0.47912843667909066 0.9922459107043483 0.018750654509869947 0.10201992172709447 0.12585657919237225 0.015638235044854724 0.044361538267139344 1.2198219956511e-07 6.913703539773389 -0.5330734927531291 FGAQQDTIEVPEKDLVDK(ub)AR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGAQQDTIEVPEKDLVDKAR 20 2 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 46871000.0 12563000.0 13056000.0 21252000.0 True False 19058989.478325266 10726054.7930064 17051532.884917498 1.0 0.5627819253064045 0.8946714044996594 24.183968292732374 -10.35170140275946 5.9842466193052966 1.0000357954987453 0.728726664903032 0.4711151697591389 0.13549331250358912 6.471640181143983e-05 7.010958291259742e-06 0.13120811385568065 0.04373027857073969 4.449370768375055e-11 10.35170140275946 -0.2713091305957134 FGAQQDTIEVPEKDLVDK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGAQQDTIEVPEKDLVDKAR 20 2 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 9922400.0 4072500.0 4054200.0 1795700.0 True False 3386464.1923402078 4032359.2199043087 2171172.5676212893 1.0 1.1907284385362884 0.6411325926706184 21.691348310451147 -6.812993117134026 1.4020721378857337 1.1035816626842767 0.6308589284825159 0.8674671574552184 0.0829469900220613 0.2027438590080707 0.7849540930402358 0.04651233041376531 0.10744615699161497 1.5381790177625037e-07 6.812993117134026 -0.4727227342017608 FGAQQDTIEVPEKDLVDK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGAQQDTIEVPEKDLVDKAR 20 2 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 61647000.0 12563000.0 19623000.0 29461000.0 True False 16263051.15375269 18530962.799996696 24099400.295387372 1.0 1.1394517931969173 1.4818498735292023 23.955094614824823 -6.955846929474578 0.49047349934883466 0.9925389333709586 1.643293648014878 0.9995838220120301 0.0041300009882176015 0.08121941268173205 0.026877247401507435 0.004934846178356976 0.02823998942976139 1.1070138910278566e-07 6.955846929474578 0.6507547146439195 FGATLEIVTDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGATLEIVTDK 11 0 P62495;B7Z7P8;P62495-2 P62495 ETF1 Eukaryotic peptide chain release factor subunit 1 0 7231100.0 2440400.0 1443000.0 3347700.0 False True 2362930.8378074234 2019197.4251455918 2470836.941152738 1.0 0.8545309040950247 1.0456662131700143 21.17214597205426 -6.703189699928053 1.8190500903435711 0.9099582243176909 1.0451423028612552 0.43299987310507126 0.06136856659599646 0.38888792866626626 2.5037851640130717 0.02688954627293352 0.06889324455246877 1.9806616833561023e-07 6.703189699928053 0.1351840785435643 FGATLEIVTDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGATLEIVTDK 11 0 P62495;B7Z7P8;P62495-2 P62495 ETF1 Eukaryotic peptide chain release factor subunit 1 0 38729000.0 9593000.0 16099000.0 13037000.0 False True 14553282.34224107 13226007.66793888 10460231.2356799 1.0 0.9087989469942627 0.7187540920111856 23.79484123898229 -6.959234162244979 0.44609691944292224 1.0063790219093103 0.6136889435401871 0.9997407273143556 0.0018864627805380509 0.07997585490839407 0.022150850395241384 0.0025258778457994723 0.015729438441598947 1.0984134388376084e-07 6.959234162244979 -0.3926900783691232 FGATLEIVTDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGATLEIVTDK 11 0 P62495;B7Z7P8;P62495-2 P62495 ETF1 Eukaryotic peptide chain release factor subunit 1 0 31845700.0 9593000.0 14991000.0 7261700.0 False True 12418327.60630023 14156737.671851909 5940145.1113341255 1.0 1.1399874540811539 0.4783369628870552 23.56596756107474 -6.8514315842239135 1.228242444069719 1.0748008936079483 0.4511591640402451 0.942351244304177 0.06835800700671021 0.15589087423579934 0.4518461377539893 0.043534640206435105 0.10083326633115097 1.4078890000772088e-07 6.8514315842239135 -0.6236417295677033 down FGAVFLWDSGSSVGEITGHNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGAVFLWDSGSSVGEITGHNK 21 0 O75083;D6RD66 O75083 WDR1 WD repeat-containing protein 1 0 9810900.0 3560300.0 2481800.0 3768800.0 False True 3447280.2253096905 3472795.682416023 2781638.218423529 1.0 1.0074016196649753 0.8069080656689688 21.717027147760273 -6.898328611992882 0.9717882631650125 1.008722353816554 0.7865639147624535 0.985715842590066 0.011093289369614314 0.11264551400648833 0.18444595952664958 0.008587889206306482 0.022162273933421097 1.2637797377227308e-07 6.898328611992882 -0.2221584390541005 FGAVWTGDNTAEWDHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGAVWTGDNTAEWDHLK 17 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 20870400.0 4221900.0 6138500.0 10510000.0 False True 5534951.78493776 5222659.727685587 9422526.01903885 1.0 0.9435781792892917 1.7023682202038921 22.40013931904389 -6.888993131513304 1.0283446305571862 0.9582395944990654 1.7663523977390232 0.9802450944573462 0.0485140647836464 0.11996291330361085 0.22666201301404387 0.03599357935612167 0.08941141111809695 1.2912396947630135e-07 6.888993131513304 0.8081128032399578 FGAVWTGDNTAEWDHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGAVWTGDNTAEWDHLK 17 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 16711500.0 4221900.0 4157100.0 8332500.0 False True 5782850.52255753 3973425.57630864 6364535.113224268 1.0 0.6871050117600738 1.100587865516794 22.463349380566783 -6.70432711437455 1.815355474079466 0.806531933450181 1.0994651280530905 0.438119947386023 0.13197579806598023 0.38661642290864523 2.479896278048571 0.05793240950451914 0.1482008157298338 1.9754811300635233e-07 6.70432711437455 0.29293319460290945 FGDEPVTK(ub)HSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGDEPVTKHSR 11 1 Q9NR19;Q9NR19-2 Q9NR19 ACSS2 Acetyl-coenzyme A synthetase, cytoplasmic 1 4021000.0 1082900.0 1768400.0 1169700.0 True False 1419692.3868185175 1504561.6131692089 1048670.6645546851 1.0 1.0597800108943884 0.7386604832788606 20.437146935612237 -6.858617237301752 1.1928297375222452 1.0323200469817109 0.7235260562890506 0.9519196479208416 0.0305751682155011 0.14823768463178197 0.4015949136450512 0.02000380186886219 0.04662068242547969 1.384786313972128e-07 6.858617237301752 -0.3087939906926602 FGDEPVTK(ub)HSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGDEPVTKHSR 11 1 Q9NR19;Q9NR19-2 Q9NR19 ACSS2 Acetyl-coenzyme A synthetase, cytoplasmic 1 3690170.0 1249600.0 1458000.0 982570.0 True False 1209932.1319964584 2040187.003369558 725205.4405318414 1.0 1.6861995391453326 0.5993769578920185 20.20649469485861 -6.7360896887582635 1.701292731907502 1.410130436981287 0.5993012731897788 0.5871505195110106 0.2883499285741098 0.32493230317804095 1.845115629781741 0.13417622100478935 0.33064468933039487 1.8361591079603313e-07 6.7360896887582635 -0.8108291637915083 FGDEPVTK(ub)HSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGDEPVTKHSR 11 1 Q9NR19;Q9NR19-2 Q9NR19 ACSS2 Acetyl-coenzyme A synthetase, cytoplasmic 1 4268800.0 1249600.0 2247600.0 771600.0 True False 1039097.766666256 2235491.7326863296 932937.9925246899 1.0 2.151377670513596 0.8978346623897007 19.986899970292885 -6.665141293113615 1.9542631333654055 1.7379376374550233 0.9029522427087946 0.2579054526521606 0.4896284129057798 0.47233329643775923 3.4728048113364123 0.20202642457620723 0.543272904416533 2.1620150205878998e-07 6.665141293113615 -0.8349853947462287 FGDEPVTK(ub)HSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGDEPVTKHSR 11 1 Q9NR19;Q9NR19-2 Q9NR19 ACSS2 Acetyl-coenzyme A synthetase, cytoplasmic 1 1370600.0 1370600.0 0.0 0.0 True False 1774268.7185651055 0.0 0.0 1.0 0.0 0.0 20.758793096202268 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 FGDPECQVILPLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGDPECQVILPLLK 14 0 P22102;P22102-2 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 12434060.0 959260.0 6155400.0 5319400.0 False True 1257599.1494870542 5237038.31356127 4768999.5152878435 1.0 4.164314452420978 3.792145945099445 20.262240716340564 -10.223874639992777 4.654440369714379 0.9992730089657192 3.9782301987760533 0.9884237696411667 0.15193715693271564 0.0011464131457411032 0.00019116351918629866 0.14713924698477523 0.049037506531546926 5.972076469383552e-11 10.223874639992777 2.978957189810334 FGDPECQVILPLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGDPECQVILPLLK 14 0 P22102;P22102-2 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 15846860.0 959260.0 9462100.0 5425500.0 False True 1313924.3450267734 9044033.135019597 4144108.641679957 1.0 6.883222134707695 3.1539933462421033 20.325450777863455 -9.403659387204277 9.967606212930681 0.9999046103988085 5.018607740489287 0.6075797672570321 1.5224512786358277 0.0 0.0 1.4741071114420892 0.49136903714736296 3.947667923205685e-10 9.403659387204277 4.018703130090478 FGDYNK(ub)EVHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGDYNKEVHK 10 1 P15311;E7EQR4 P15311 EZR Ezrin 1 26886400.0 10473000.0 11597000.0 4816400.0 True False 10140540.34763036 16227742.577556066 3554840.35109719 1.0 1.6002838134112018 0.3505572907589569 23.2736311938779 -6.776063485886539 1.550972701431165 1.3416253834372696 0.34180982260339166 0.7533176772348976 0.2534663696104471 0.2567264456773546 1.2194519873660021 0.1287485085594731 0.30483695035946146 1.6746980479983014e-07 6.776063485886539 -0.9998155608338779 FGDYNK(ub)EVHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGDYNKEVHK 10 1 P15311;E7EQR4 P15311 EZR Ezrin 1 35767900.0 12806000.0 8971900.0 13990000.0 True False 19427638.24400489 7370794.347225356 11224870.367965173 1.0 0.37939734385881335 0.5777784323027024 24.211607191961328 -10.052791066224708 5.12207693119905 1.0000073367561795 0.4785878880789027 0.9020651062510359 0.08098874022408777 249494537396.24957 46135731582.361694 22326960.556035582 0.02772471416145603 8.855415305935624e-11 10.052791066224708 -0.5214194486772767 FGDYNK(ub)EVHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGDYNKEVHK 10 1 P15311;E7EQR4 P15311 EZR Ezrin 1 31677900.0 10473000.0 17308000.0 3896900.0 True False 8708763.532566972 17214758.368630983 4711723.772770177 1.0 1.9767167065973608 0.541032461743896 23.054036469312177 -6.723518532643819 1.7465548897924659 1.5919819729316436 0.5428042315715098 0.5290791135814175 0.41083980646314233 0.3485432596576407 2.0796689531534933 0.1866362959853524 0.4666167998832066 1.8900855738643245e-07 6.723518532643819 -1.0491777413601338 FGDYNK(ub)EVHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGDYNKEVHK 10 1 P15311;E7EQR4 P15311 EZR Ezrin 1 34617500.0 12806000.0 13215000.0 8596500.0 True False 16577619.443998806 12479573.633081388 7032025.207538697 1.0 0.7527964841537647 0.424187877595678 23.982733514053777 -6.967186998614893 0.318290427007694 1.0459152926209718 0.12049656720412447 0.9999513887931089 0.0016444194046693894 0.07722646572025431 0.012283088122833569 0.0050160315450887855 0.028949261221124473 1.0784822491131432e-07 6.967186998614893 -0.9254187254168473 down FGDYQCNSAMGISQMLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGDYQCNSAMGISQMLK 17 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 4953700.0 1079000.0 1814400.0 2060300.0 False True 1414579.449050863 1543698.592475806 1847119.9197931255 1.0 1.0912774065193565 1.3057731900689515 20.431941776480976 -6.956774296246358 0.47873569174911973 0.9947897358022936 1.4111846455045969 0.9996312161458748 0.0024612483485608083 0.0808742042167856 0.025546756398316058 0.003016615048788098 0.017694919896579155 1.1046525610041e-07 6.956774296246358 0.4163949097023033 FGDYQCNSAMGISQMLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGDYQCNSAMGISQMLK 17 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 3021280.0 1079000.0 1197100.0 745180.0 False True 1477935.4588786021 1144208.1637196776 569183.8314638418 1.0 0.7741935933980884 0.385120898239843 20.495151838003867 -6.962851827613661 0.3931843934837599 1.0230637582049609 0.12219942037615943 0.9998617823615367 0.0029856523304865115 0.07869771832032081 0.0174792176485215 0.005015510057200507 0.032684732232887474 1.0893016773735071e-07 6.962851827613661 -0.9008643378288015 down FGEDAGYTK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGEDAGYTKR 10 1 Q5VVQ6-2;Q5VVQ6 Q5VVQ6-2 YOD1 Ubiquitin thioesterase OTU1 1 8342400.0 3521000.0 2454000.0 2367400.0 True False 4616065.0974125005 2087872.7656170796 2122444.1577043342 1.0 0.45230574559865294 0.4597951096690672 22.13823213885609 -10.41553325968244 9.186065724632588 1.0000023259948525 0.45605042763426934 0.9998578412240989 0.00305752007840811 1.456521223900877e-07 9.268437916485486e-09 0.002960443739603103 0.0009868103620307815 3.841198409068835e-11 10.41553325968244 -0.5439518983605831 FGEDAGYTK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGEDAGYTKR 10 1 Q5VVQ6-2;Q5VVQ6 Q5VVQ6-2 YOD1 Ubiquitin thioesterase OTU1 1 12502100.0 4928800.0 3997800.0 3575500.0 True False 7477349.943546106 3284361.3550460343 2868800.857802677 1.0 0.43924135955156834 0.3836654535981445 22.834095622763204 -13.999999999999998 0.32677949042818505 6.987186730661295 0.3734479758502595 0.9997081182609467 0.004755816655744422 18.5549577344737 0.18263032868593218 76.22366424533855 0.018026552250747632 1.0000000000000041e-14 13.999999999999998 -6.613738754811036 FGEDAGYTK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGEDAGYTKR 10 1 Q5VVQ6-2;Q5VVQ6 Q5VVQ6-2 YOD1 Ubiquitin thioesterase OTU1 1 8914000.0 3521000.0 2888000.0 2505000.0 True False 4822808.8514472265 2760398.610661124 1913370.5920944263 1.0 0.5723632629215202 0.39673365688550205 22.20144220037898 -13.999999999999998 0.12230209440151561 3.0352219060949657 0.1249197809478676 0.9996817246311027 0.00451972489447292 11.95550435010491 0.10791884621753478 5.896785296300076 0.24125979746020404 1.0000000000000041e-14 13.999999999999998 -2.910302125147098 FGEDAGYTK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGEDAGYTKR 10 1 Q5VVQ6-2;Q5VVQ6 Q5VVQ6-2 YOD1 Ubiquitin thioesterase OTU1 1 11877000.0 4928800.0 3876800.0 3071400.0 True False 6380428.761172999 3661052.6720189163 2512436.715225312 1.0 0.5737941459824177 0.3937723951271603 22.605221944855654 -13.999999999989422 0.11793407428954113 3.034867702116594 0.09828265040937985 0.9997031364466815 0.004379839977172337 11.972164069733294 0.10541705378865121 5.7260154427728125 0.26219644270474995 1.0000000000243572e-14 13.999999999989422 -2.936585051707214 FGEDAGYTKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGEDAGYTKR 10 1 Q5VVQ6-2;Q5VVQ6 Q5VVQ6-2 YOD1 Ubiquitin thioesterase OTU1 0 2716500.0 946310.0 1076800.0 693390.0 False True 916269.907033906 1506771.855437818 511770.3577458844 1.0 1.6444628857401304 0.5585366864252442 19.80541311225855 -6.745935346982938 1.6650010369828114 1.3807952857447514 0.5570442639982939 0.6312583736539151 0.27077002237441733 0.3071848107666314 1.6741892644088796 0.12854154992441183 0.3133936892131698 1.795000827052813e-07 6.745935346982938 -0.8237510217464575 FGEDAGYTKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGEDAGYTKR 10 1 Q5VVQ6-2;Q5VVQ6 Q5VVQ6-2 YOD1 Ubiquitin thioesterase OTU1 0 3383600.0 1225100.0 1269800.0 888700.0 False True 1678052.577082647 1213696.0373329269 678807.3633510238 1.0 0.7232765253654804 0.40452091467309925 20.67835648862281 -6.969274281049748 0.2749752080772335 1.074610413526869 0.04354008436352397 0.9999761520858457 0.0011881500535333605 0.0765389625469475 0.00987035907510057 0.006063545140707509 0.02944801370277481 1.073311342609578e-07 6.969274281049748 -1.0310703291633452 down FGEDAGYTKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGEDAGYTKR 10 1 Q5VVQ6-2;Q5VVQ6 Q5VVQ6-2 YOD1 Ubiquitin thioesterase OTU1 0 2899260.0 946310.0 1270000.0 682950.0 False True 786898.693641121 1263158.2579247365 825751.6873959784 1.0 1.6052361862235114 1.0493748357556392 19.585818387692825 -10.207476792529663 4.855647228422486 0.9999535816013942 1.3273055109900453 0.31614008384218917 0.22692944606599702 0.00011406197592160929 1.8617146272941714e-05 0.21975459844760328 0.07324116378110977 6.201877838516082e-11 10.207476792529663 0.3273519293886511 FGESDTENQNNK(ub)SVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGESDTENQNNKSVK 15 1 Q9BQI3-2;Q9BQI3 Q9BQI3-2 EIF2AK1 Eukaryotic translation initiation factor 2-alpha kinase 1 1 2343640.0 397220.0 671620.0 1274800.0 True False 384610.46852723486 939801.3684520301 940891.6368197601 1.0 2.443514790563953 2.4463495245531366 18.553038505671008 FGESDTENQNNK(ub)SVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGESDTENQNNKSVK 15 1 Q9BQI3-2;Q9BQI3 Q9BQI3-2 EIF2AK1 Eukaryotic translation initiation factor 2-alpha kinase 1 1 9159730.0 893930.0 2271900.0 5993900.0 True False 1356157.165036959 1866461.6945642785 4809203.037780304 1.0 1.3762871610189902 3.5461988932892154 20.371092951397543 -6.936679929383808 0.689755482624752 0.973687809354423 4.078311292548234 0.9976959493893266 0.053864390501566876 0.08931437822668169 0.06175422535254406 0.05119728954980817 0.18965217902690162 1.1569645992070573e-07 6.936679929383808 3.104623483193811 up FGESDTENQNNK(ub)SVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGESDTENQNNKSVK 15 1 Q9BQI3-2;Q9BQI3 Q9BQI3-2 EIF2AK1 Eukaryotic translation initiation factor 2-alpha kinase 1 1 2346900.0 397220.0 1093900.0 855780.0 True False 330306.0298296813 1088006.9435778519 1034719.6413203481 1.0 3.2939360632891583 3.1326089985517065 18.333443781105284 -10.353088910564951 5.54188133597021 0.99942465227377 3.213272530920456 0.9960310209409159 0.06586149838469998 0.0004682847189882747 5.466367353500199e-05 0.06378321357838007 0.021256707200005512 4.435178358282794e-11 10.353088910564951 2.213847878646686 FGEVVDCTIK(ub)TDPVTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGEVVDCTIKTDPVTGR 17 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 1 6282100.0 1387400.0 2205100.0 2689600.0 True False 1818894.8356007119 1876107.6754124796 2411305.992464973 1.0 1.0314547266240779 1.3256984105233387 20.79463070134969 -6.927306430579518 0.7685662156615628 0.9950504460491075 1.3821630519184323 0.9959822200221405 0.009297762943306259 0.09406023067467056 0.08470585769202153 0.008338825609270933 0.027028894006938118 1.1822071167424706e-07 6.927306430579518 0.3871126058693247 FGEVVDCTIK(ub)TDPVTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGEVVDCTIKTDPVTGR 17 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 1 8972300.0 1387400.0 4167500.0 3417400.0 True False 1900359.2730752302 3983366.0699204328 2610280.5035622735 1.0 2.096112101726115 1.3735721137289072 20.85784076287258 -10.164351057591313 4.879886606182461 0.9999385790490641 1.7348421077298903 0.5796770649443778 0.2949757148998695 206636818.91686144 16.277495765297342 142611.482453712 0.10097803310305067 6.849343428090779e-11 10.164351057591313 0.7349035286808262 FGEVVDCTIK(ub)TDPVTGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGEVVDCTIKTDPVTGR 17 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 1 6092000.0 2783700.0 1142300.0 2166000.0 True False 2314769.8888195055 1136146.2031712017 2618900.5855475366 1.0 0.49082468571017124 1.131387010949556 21.14243735168248 -6.6949335885880865 1.849006607076091 0.682262177956706 1.1293058832511778 0.39353032457146175 0.2151353397035025 0.40616334002659593 2.69594946604358 0.09295241658017049 0.24054929460320984 2.0186750316818103e-07 6.6949335885880865 0.4470437052944718 FGEVVDCTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGEVVDCTLK 10 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 130184400.0 5540400.0 68125000.0 56519000.0 False True 7263518.053309929 57961015.5491702 50670956.0485306 1.0 7.979744130016696 6.9760900539705055 22.79223704987612 -10.443113649489236 6.623985273808799 0.9986737408289105 7.477917091993601 0.9823148276030894 0.40974006076294534 0.008023574270632838 0.0006745503500903311 0.396646876803215 0.13224303596740858 3.6048429640003035e-11 10.443113649489236 6.4792433511646905 FGEVVDCTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGEVVDCTLK 10 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 43015900.0 29871000.0 2521900.0 10623000.0 False True 28922761.455558706 3528907.8215347594 7840517.6168311285 1.0 0.12201144164457138 0.27108468286745313 24.785701967124602 -10.616226982023345 8.290294167164761 1.000528894060694 0.1965480622560127 0.974830761509968 0.06085889588314855 0.0005952592301718167 2.755559795840187e-05 0.05895914158655864 0.019642124185333776 2.4197640375895617e-11 10.616226982023345 -0.8039808318046813 FGEVVDCTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGEVVDCTLK 10 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 82275400.0 5540400.0 58257000.0 18478000.0 False True 7588835.603680277 55683013.109863184 14113876.966355618 1.0 7.33749102205603 1.8598211508905214 22.855447111399013 -6.6107040492442914 2.1500968644807616 5.231906995423944 1.8791061948437027 0.05281669457751914 2.7317643552859825 0.6107779839598293 5.351151731556993 1.0485483132359958 3.0341939187143914 2.450732729168149e-07 6.6107040492442914 -3.352800800580241 FGEVVDCTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGEVVDCTLK 10 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 33870500.0 29871000.0 1121900.0 2877600.0 False True 24839060.009673245 1115856.1020202853 3479292.85548088 1.0 0.044923443221512 0.1400734510132797 24.56610724255888 -10.55459571521981 6.003817663146648 1.0019218578608342 0.09249844756405862 0.9918225452110431 0.03884482801861258 0.0010006783020922493 7.423710523539837e-05 0.03766427104986666 0.012537114333531461 2.7887159766932514e-11 10.55459571521981 -0.9094234102967755 FGEVVDCTLK(ub)LDPITGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGEVVDCTLKLDPITGR 17 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 14834700.0 4520000.0 5820100.0 4494600.0 True False 5925763.77174227 4951763.766572108 4029541.907247576 1.0 0.8356330014681312 0.6800038041446977 22.49856968429551 -6.971787007143404 0.2111881410674597 1.080255944520148 0.43103047611793355 0.9999931668894186 0.0003414839648549535 0.07572704698084418 0.0069157094393185415 0.00461671566796394 0.016082933913153626 1.067119344713496e-07 6.971787007143404 -0.6492254684022145 FGEVVDCTLK(ub)LDPITGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGEVVDCTLKLDPITGR 17 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 17193200.0 4520000.0 6736200.0 5937000.0 True False 6191166.148407128 6438572.410365464 4534802.876353133 1.0 1.0399611730694693 0.73246344350165 22.561779745818402 -6.87421469316377 1.111493180429518 1.0232956029357976 0.7129461623756956 0.9687147057688514 0.024146326418057758 0.13288124144009428 0.3042685691190219 0.0168120980823619 0.040123582306334074 1.3359349348097433e-07 6.87421469316377 -0.31034944056010194 FGEVVDCTLK(ub)LDPITGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGEVVDCTLKLDPITGR 17 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 32626000.0 17157000.0 9328100.0 6140900.0 True False 14266805.68397322 9277847.67381713 7424933.797686466 1.0 0.6503100889808506 0.5204342136675592 23.76615901796271 -13.999999999999998 0.13756651742099427 2.6671698379545417 0.3548943885910912 0.9996128112777546 0.003985031276660219 11.93233225105277 0.11602242947821254 5.347900620061104 0.14776212303513456 1.0000000000000041e-14 13.999999999999998 -2.3122754493634505 FGEVVDCTLK(ub)LDPITGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGEVVDCTLKLDPITGR 17 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 69676000.0 19125000.0 20436000.0 30115000.0 True False 24757689.510110658 19298718.63531222 24634379.0059941 1.0 0.7795040255041134 0.9950193048480473 24.56137334678307 -10.749149604176438 8.807666499351033 1.0006960893485228 0.8872616651854285 0.26732393234997487 0.08798374436100294 0.0012098119544794988 3.445652563413437e-05 0.08569897601434143 0.02839663138726126 1.7817648858620858e-11 10.749149604176438 -0.11343442416309435 FGFAIGSQTTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGFAIGSQTTK 11 0 Q8WW12;Q8WW12-2 Q8WW12 PCNP PEST proteolytic signal-containing nuclear protein 0 200696000.0 54873000.0 46877000.0 98946000.0 False True 71939034.39088787 39883134.32511487 88708017.07705215 1.0 0.5544018579455197 1.2330999133940046 26.10027145909174 -6.7295531447332655 1.7245409813978776 0.7317191907804402 1.2326902520264271 0.5573867524025048 0.18732482728297167 0.33704933413939897 1.9635271054077519 0.08608124080491074 0.21373887353865995 1.8640040656137944e-07 6.7295531447332655 0.5009710612459869 FGFAIGSQTTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGFAIGSQTTK 11 0 Q8WW12;Q8WW12-2 Q8WW12 PCNP PEST proteolytic signal-containing nuclear protein 0 150070000.0 46629000.0 22312000.0 81129000.0 False True 45148787.91842415 31221297.95554293 59878881.08217001 1.0 0.6915201801641779 1.3262566691792594 25.428183921296384 -6.774532801421785 1.5570818395088803 0.8241003691150153 1.33046052870275 0.7476738257393123 0.1301834446138189 0.2591227308460335 1.2404244403493074 0.06587834946128787 0.1561763528764631 1.6806109876194753e-07 6.774532801421785 0.5063601595877347 FGFAIGSQTTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGFAIGSQTTK 11 0 Q8WW12;Q8WW12-2 Q8WW12 PCNP PEST proteolytic signal-containing nuclear protein 0 108385000.0 32735000.0 34805000.0 40845000.0 False True 49661388.24906289 28593775.817293797 32771967.847000565 1.0 0.5757747985998631 0.6599084117955356 25.565621255811763 -10.101887007977602 5.318627808059938 1.0000063902003913 0.6178416051974147 0.9649242653140252 0.03434740375871401 2.6026851071909673e-06 4.394286612943649e-07 0.03325728650476243 0.011085576895097666 7.908843685836593e-11 10.101887007977602 -0.38216478500297657 FGFAIGSQTTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGFAIGSQTTK 11 0 Q8WW12;Q8WW12-2 Q8WW12 PCNP PEST proteolytic signal-containing nuclear protein 0 149996000.0 54873000.0 42567000.0 52556000.0 False True 75161030.98706724 40686249.18975484 40143355.22479629 1.0 0.541321062995472 0.5340979853203937 26.16348152061463 FGFAIGSQTTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGFAIGSQTTK 11 0 Q8WW12;Q8WW12-2 Q8WW12 PCNP PEST proteolytic signal-containing nuclear protein 0 94717000.0 46629000.0 22639000.0 25449000.0 False True 38774079.51494943 22517039.21351034 30770268.23711877 1.0 0.5807240170544563 0.7935783033935138 25.20858919673066 -10.268930540453082 4.787149713012794 1.0000989901480306 0.6871511602235026 0.7422903051616823 0.08689739851758245 9.18371210828415e-05 1.402495718543279e-05 0.08416456523891676 0.028046014773695963 5.38355878395425e-11 10.268930540453082 -0.31294782992452796 FGFAIGSQTTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGFAIGSQTTK 11 0 Q8WW12;Q8WW12-2 Q8WW12 PCNP PEST proteolytic signal-containing nuclear protein 0 127093000.0 32735000.0 63465000.0 30893000.0 False True 42376102.80331878 59933116.95978129 25270790.988948196 1.0 1.4143140353880652 0.596345329494742 25.336747577904212 -6.769030680299153 1.5784425895679974 1.2379364026393629 0.5919419810069088 0.7267396910961055 0.17456679255244772 0.26799915950046366 1.3176577498730213 0.08718589876873542 0.2077001975076969 1.7020382653574464e-07 6.769030680299153 -0.6459944216324541 FGFELPQGPLGTSFKGK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGFELPQGPLGTSFKGK 17 1 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 50638200.0 8230200.0 13046000.0 29362000.0 True False 7968936.805983704 18255335.833991256 21671211.35888123 1.0 2.2908119713389765 2.719460812213843 22.92595582590475 -9.974669519828463 0.2727294949689244 4.21823339365486e-15 2.9148606201531035 0.9989854661410517 0.023276925326787268 1.4058805698452184 0.12213246337662148 1.2634704528609764 0.17167236787012577 1.0600600802950257e-10 9.974669519828463 2.9148606201530995 FGFELPQGPLGTSFKGK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGFELPQGPLGTSFKGK 17 1 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 102069000.0 15395000.0 32358000.0 54316000.0 True False 23355340.525258128 26583462.085792065 43580418.79245154 1.0 1.1382177047276538 1.8659723134980872 24.477249144268065 -6.938659418757153 0.6719251515591704 0.9916109463433062 2.0547160251357215 0.9979829159757972 0.017060231808897076 0.08838365885248542 0.057436107136702046 0.016442755757814575 0.0630153732768324 1.1517032204717082e-07 6.938659418757153 1.0631050787924154 FGFGFGGTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGFGFGGTGK 10 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 131031000.0 34470000.0 35232000.0 61329000.0 False True 45190503.80795486 29975522.93326037 54983263.389308654 1.0 0.6633146437279549 1.216699500031464 25.429516305247592 -6.7420156178630055 1.6792058057555823 0.8001435794088889 1.2171757277645574 0.6139986712108445 0.14145635895193423 0.31418428246901886 1.740232890709874 0.06662010699142598 0.16312644863291706 1.8112749553591806e-07 6.7420156178630055 0.4170321483556685 FGFGFGGTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGFGFGGTGK 10 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 124080000.0 30558000.0 13019000.0 80503000.0 False True 29587953.016603485 18217554.59318811 59416849.26176742 1.0 0.6157085143053054 2.008143288196559 24.81850655422268 -6.833103904152657 1.3139345440025711 0.7950559735646334 2.048057313280395 0.9119454888993999 0.17423642842432466 0.1770153668119331 0.5965668478281252 0.10408050250342524 0.23952862977201633 1.4685748817821166e-07 6.833103904152657 1.2530013397157616 up FGFGFGGTGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGFGFGGTGK 10 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 26750700.0 10249000.0 8072500.0 8429200.0 False True 15548482.302265061 6631899.3042696165 6763164.925350396 1.0 0.42653033108598 0.43497267410885215 23.890270429014024 -10.05863009749392 5.473678630130965 1.0000040044746314 0.43075150259706085 0.9998350649150665 0.0034465721078500845 1.6843012704382953e-07 2.8962646500012068e-08 0.0033371525557752482 0.0011123763644189332 8.737152227717963e-11 10.05863009749392 -0.5692525018775706 FGFGFGGTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGFGFGGTGK 10 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 103233000.0 34470000.0 24907000.0 43856000.0 False True 47214490.51672426 23806526.38356529 33498116.04267189 1.0 0.5042207619529977 0.7094880337807781 25.492726366770484 -10.229655598374618 5.518707420990943 1.000022041850675 0.6068543978668657 0.8302522899260719 0.08380001281195196 2.2727656614656054e-05 3.1723763381033794e-06 0.08114355629625333 0.027046337836043304 5.893108018491036e-11 10.229655598374618 -0.3931676439838092 FGFGFGGTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGFGFGGTGK 10 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 71721000.0 30558000.0 19218000.0 21945000.0 False True 25410330.948933575 19114468.819525663 26533598.037784256 1.0 0.7522321868982923 1.0442051341679917 24.598911829656956 -6.681802864573657 1.8950429170091003 0.843496132874347 1.0431228725048902 0.33264213529178543 0.10496745308191632 0.43449990036404734 3.018238014727004 0.04441632645940318 0.11689401685476707 2.080640919586397e-07 6.681802864573657 0.19962673963054323 FGFGFGGTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGFGFGGTGK 10 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 39866500.0 10249000.0 20349000.0 9268500.0 False True 13267532.537993439 19216560.261791367 7581728.102840984 1.0 1.4483899102385507 0.5714497462983146 23.661396751106473 -6.767722696950498 1.5833111055963065 1.2579295517497553 0.5669495109810686 0.7217463363425639 0.18886514920913156 0.2701150887282361 1.3360377694276995 0.09404613555180152 0.22432705573383463 1.7071720941273888e-07 6.767722696950498 -0.6909800407686867 FGFGFGNGMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGFGFGNGMK 10 0 V9GZ50;Q9ULX6-2;Q9ULX6 V9GZ50 AKAP8L A-kinase anchor protein 8-like 0 21606700.0 7017500.0 4797100.0 9792100.0 False True 9200010.45756667 4081391.378949343 8778907.424455784 1.0 0.44362899344234435 0.9542279832122861 23.133204070392846 -10.540084080664759 9.242027618885627 1.000016908848552 0.6989284883273157 0.31674062010765003 0.20845116468615418 7.262916397496506e-05 3.6145081589662893e-06 0.20184328199662077 0.06727732411058453 2.8834732003526132e-11 10.540084080664759 -0.3010884205212363 FGFGFGNGMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGFGFGNGMK 10 0 V9GZ50;Q9ULX6-2;Q9ULX6 V9GZ50 AKAP8L A-kinase anchor protein 8-like 0 15576900.0 4371200.0 2113400.0 9092300.0 False True 4232438.648673903 2957291.6412354074 6710753.866846803 1.0 0.6987204982078071 1.5855525440278735 22.013057725006718 -6.815039313754089 1.39323938092135 0.8367552436471865 1.602922720558498 0.8725832586095557 0.13142920361921084 0.20000626299613872 0.7641597391241075 0.07415462796000859 0.17117804905028314 1.5309488689203824e-07 6.815039313754089 0.7661674769113115 FGFGFGNGMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGFGFGNGMK 10 0 V9GZ50;Q9ULX6-2;Q9ULX6 V9GZ50 AKAP8L A-kinase anchor protein 8-like 0 19016700.0 7017500.0 5024800.0 6974400.0 False True 9612059.390806856 4802787.721208451 5327190.362276793 1.0 0.4996627180437444 0.5542194597103522 23.196414131915738 -10.427057680759678 5.3691570738076 1.0003969153744636 0.5269410888770432 0.9901231850581069 0.02227269651868925 0.00010590884802329189 1.1301504631332793e-05 0.02158301512232345 0.0071884818909986785 3.740609041270947e-11 10.427057680759678 -0.47345582649742046 FGFGFGNGMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGFGFGNGMK 10 0 V9GZ50;Q9ULX6-2;Q9ULX6 V9GZ50 AKAP8L A-kinase anchor protein 8-like 0 10399700.0 4371200.0 2541900.0 3486600.0 False True 3634846.476993862 2528206.2801723564 4215631.939783035 1.0 0.695546922318234 1.1597826666037079 21.793463000440994 -6.72976358501359 1.7239081519087889 0.8167359062125797 1.1595042011963446 0.558255295766487 0.12798721883234648 0.33667937690146355 1.9600551273484361 0.058834588551340314 0.14604339245302836 1.8631010688378416e-07 6.72976358501359 0.3427682949837648 FGFIFNCDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGFIFNCDIK 10 0 O00442-2;O00442 O00442-2 RTCA RNA 3-terminal phosphate cyclase 0 18765200.0 6515900.0 4790200.0 7459100.0 False True 9885096.676098034 3935351.3839965705 5984805.61556033 1.0 0.3981095494505553 0.6054372366465035 23.236823644883632 -10.082458670224066 5.041937775467864 1.000011782586193 0.5017733930466843 0.8850544814503426 0.08464117387001012 1.1210620912472037e-05 2.040221315676539e-06 0.08195540068620913 0.027317821399244012 8.27068213038992e-11 10.082458670224066 -0.4982383895395086 FGFIGFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGFIGFK 7 0 Q9Y4C8 Q9Y4C8 RBM19 Probable RNA-binding protein 19 0 7857300.0 2093200.0 1798400.0 3965700.0 False True 2744205.470577634 1530085.7301082958 3555367.405680533 1.0 0.5575696668902218 1.2955908162853986 21.387957075720312 -6.744368871978715 1.670847500084861 0.7380951982616072 1.2964367413466906 0.6243374375351043 0.18588261532162106 0.30996422132963125 1.700693869363248 0.08795574557495896 0.21479691390953742 1.8014869814731565e-07 6.744368871978715 0.5583415430850834 FGFIGFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGFIGFK 7 0 Q9Y4C8 Q9Y4C8 RBM19 Probable RNA-binding protein 19 0 5625790.0 1921600.0 922990.0 2781200.0 False True 1860599.8598306621 1291544.7203292637 2052720.2857884488 1.0 0.6941550132368657 1.1032572505811498 20.827336392422264 -6.706614437228532 1.8074202880380097 0.8113222990260875 1.1021965221349022 0.44891010283721255 0.12895231757886377 0.38193864663686605 2.430049201637182 0.05682434075205237 0.14494834368117612 1.9651041045590956e-07 6.706614437228532 0.2908742231088146 FGFIGFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGFIGFK 7 0 Q9Y4C8 Q9Y4C8 RBM19 Probable RNA-binding protein 19 0 5757700.0 2093200.0 1457300.0 2207200.0 False True 2867112.6066030497 1392911.6673533407 1685904.8187109036 1.0 0.48582384387185273 0.5880148602563472 21.451167137243203 -9.980948949870093 5.8934911488514095 1.0000004569706291 0.5369193520640673 0.9647633790705745 0.041719307740134284 2.5045735885510234e-07 4.3304887981952474e-08 0.04039458574855117 0.013464848674345083 1.0448430304464381e-10 9.980948949870093 -0.46308110490656185 FGFPAFSGISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGFPAFSGISR 11 0 P53004 P53004 BLVRA Biliverdin reductase A 0 27133800.0 6750600.0 7827200.0 12556000.0 False True 8850101.972903384 6659412.270186631 11256825.565656675 1.0 0.7524672925324418 1.2719430352466026 23.077262647678506 -6.777158419054642 1.5472163062489412 0.8593215447889321 1.2756772756463532 0.7571063147150284 0.10455806253645888 0.25501888467880374 1.2056567527524806 0.05324002263014097 0.12591146632005104 1.6704811561468558e-07 6.777158419054642 0.41635573085742117 FGFPAFSGISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGFPAFSGISR 11 0 P53004 P53004 BLVRA Biliverdin reductase A 0 15711900.0 6750600.0 4316100.0 4645200.0 False True 9246479.24810555 4125400.43056595 3548099.430897018 1.0 0.4461590536107217 0.3837243707245614 23.140472709201397 -13.999999999999998 0.30812983895563567 6.295451512202606 0.3696188058395171 0.9996678777598572 0.005047640068332938 17.137706110753403 0.17655270643767634 58.124773785592666 0.02180303502237502 1.0000000000000041e-14 13.999999999999998 -5.925832706363089 FGFPEGSVELYAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGFPEGSVELYAEK 14 0 P23396;E9PPU1;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 0 13910900.0 3840700.0 5719900.0 4350300.0 False True 5035194.893391703 4866513.215995576 3900172.6870242367 1.0 0.9664994740089389 0.7745822693264378 22.263616189917325 -6.93682153072121 0.6884961118860372 1.0023179126795316 0.7273336172285212 0.997717265936107 0.0047449697770939 0.0892470490076899 0.06143958654880455 0.004514392436065375 0.016762273277575162 1.1565874333982394e-07 6.93682153072121 -0.27498429545101044 FGFPEGSVELYAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGFPEGSVELYAEK 14 0 P23396;E9PPU1;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 0 61639000.0 19293000.0 12506000.0 29840000.0 False True 18680554.27545427 17499711.01792843 22024008.819188613 1.0 0.9367875684996436 1.1789804785464824 24.155033926463915 -6.837388557783391 1.294622199623428 0.9663539506443901 1.1865357076559695 0.9198420146291411 0.029040081938448713 0.17187412014695583 0.5607269511500036 0.01759704194630628 0.040512815773505906 1.454157482088543e-07 6.837388557783391 0.22018175701157938 FGFPEGSVELYAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGFPEGSVELYAEK 14 0 P23396;E9PPU1;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 0 191080000.0 27295000.0 113950000.0 49835000.0 False True 41408510.53179087 93614732.20458637 39985090.40654356 1.0 2.2607606746133704 0.9656249377974006 25.303423973969664 -6.652265854338076 2.000044437755677 1.8166105947611622 0.9710213365552164 0.20348262432238162 0.5378020164709799 0.5029793673506895 3.858980892255294 0.2178615523985444 0.5959117513519613 2.2270714251573978e-07 6.652265854338076 -0.8455892582059458 FGFPEGSVELYAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGFPEGSVELYAEK 14 0 P23396;E9PPU1;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 0 16258100.0 3840700.0 4889500.0 7527900.0 False True 5260710.581014871 4673465.722585718 5749965.061967112 1.0 0.888371570839036 1.0930015961565893 22.326826251440217 -6.758579069031742 1.6178840297532184 0.9350456948125027 1.093695580930213 0.685125281432422 0.04694199608919639 0.28530585124328484 1.4715575105737335 0.022896557968602516 0.05510007872019542 1.743495902170787e-07 6.758579069031742 0.15864988611771025 FGFPEGSVELYAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGFPEGSVELYAEK 14 0 P23396;E9PPU1;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 0 38843600.0 19293000.0 8514600.0 11036000.0 False True 16042984.324817592 8468730.159784233 13343576.575301293 1.0 0.5278774814161967 0.8317390521076264 23.93543920189819 -10.103191646259651 5.202081062380705 1.0000069205460282 0.6798082667614835 0.596854917071658 0.12405096677393798 9.957021394132652e-06 1.7165681700530932e-06 0.12011442650813575 0.04003727736615044 7.885120847855815e-11 10.103191646259651 -0.3201986537845447 FGFPEGSVELYAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGFPEGSVELYAEK 14 0 P23396;E9PPU1;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 0 106251000.0 27295000.0 41625000.0 37331000.0 False True 35333915.564887375 39308532.15868425 30537141.04840658 1.0 1.112487295287098 0.864244467679446 25.074550296062114 -6.783478315978951 1.5220203134243089 1.0634042216372372 0.8620483005013336 0.7796163719901049 0.047645922781079666 0.2451979112430285 1.1220637085098035 0.02464924211283817 0.058002384724837576 1.6463481652936265e-07 6.783478315978951 -0.20135592113590361 FGFPEGSVELYAEK(ub)VATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGFPEGSVELYAEKVATR 18 1 P23396;E9PPU1;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 1 64412500.0 9883500.0 12141000.0 42388000.0 True False 12957364.21195014 10329610.125247339 38002096.37440709 1.0 0.797199951801979 2.932857003383376 23.627268939140198 -6.883627318902209 1.0593935755044024 0.8671129672236796 3.095124937417866 0.9764942087223502 0.14757051900378756 0.12446413907474319 0.2532977931011904 0.10693165253933307 0.2611367769288553 1.3072922335392046e-07 6.883627318902209 2.2280119701941867 up FGFPEGSVELYAEK(ub)VATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGFPEGSVELYAEKVATR 18 1 P23396;E9PPU1;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 1 328978800.0 54447000.0 53089000.0 221442800.0 True False 52718609.78778094 74287714.55547768 163440287.53839895 1.0 1.4091364482964042 3.1002389516022664 25.65180899057573 -6.944121667759484 0.6200329820189028 0.9814919080694207 3.617480328470989 0.9986554557096212 0.03333503539244894 0.08593558113834551 0.04641754595277913 0.0335699053276084 0.14312037991283222 1.1373086237579292e-07 6.944121667759484 2.6359884204015684 up FGFPEGSVELYAEK(ub)VATR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGFPEGSVELYAEKVATR 18 1 P23396;E9PPU1;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 1 1280880000.0 105210000.0 223190000.0 952480000.0 True False 159611261.8812865 183360000.70857078 764221910.5131856 1.0 1.1487911225521654 4.788019977447382 27.249987208197215 -6.915504054515139 0.8574099868425825 0.9059731018376116 5.318204505360328 0.9928381610239778 0.14823995727721895 0.10088975012113466 0.11985674559702658 0.12477125363058479 0.35909114207564974 1.2147752794389098e-07 6.915504054515139 4.412231403522717 up FGFPEGSVELYAEK(ub)VATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGFPEGSVELYAEKVATR 18 1 P23396;E9PPU1;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 1 248487100.0 9883500.0 9201800.0 229401800.0 True False 13537697.041544635 8795234.049716586 175221819.5183742 1.0 0.6496846563138231 12.943251646173758 23.69047900066309 -6.900340597442964 0.9591075592461289 0.4936442598575976 14.242652528025546 0.9867351345104635 0.6581529590424909 0.11115516349344831 0.17600729602999787 0.5143309581456995 1.3405093117529774 1.2579384808085194e-07 6.900340597442964 13.749008268167948 up FGFPEGSVELYAEK(ub)VATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGFPEGSVELYAEKVATR 18 1 P23396;E9PPU1;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 1 424677000.0 54447000.0 74960000.0 295270000.0 True False 45275092.91107358 74556175.60160491 357009591.8257717 1.0 1.6467371088126388 7.885342003096204 25.432214266010007 -6.926790378714763 0.7726840479835265 0.8929908416027829 9.06733900025277 0.9958689654209422 0.19954179585465434 0.0943389055785926 0.08609830389147888 0.17843452593279954 0.5747696055445524 1.1836127132238312e-07 6.926790378714763 8.174348158649988 up FGFPEGSVELYAEK(ub)VATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGFPEGSVELYAEKVATR 18 1 P23396;E9PPU1;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 1 1338801700.0 105210000.0 196091700.0 1037500000.0 True False 136196418.99915 185179024.51654202 848685645.6489749 1.0 1.3596467945144557 6.2313359770073795 27.021113530289664 -6.921719338694383 0.8118638870733945 0.8990256592895229 7.048896695626665 0.9946455314486032 0.17458113709207757 0.09717071261932628 0.1004464469171641 0.15180553946314962 0.4624871190748345 1.1975141706870364e-07 6.921719338694383 6.149871036337142 up FGGALDAAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGGALDAAAK 10 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 13207600.0 2690400.0 5605300.0 4911900.0 False True 3527140.453870665 4769011.089288268 4403663.706271825 1.0 1.3520899299756497 1.2485081793210897 21.75006759563218 -10.122865159125086 4.576123287812422 0.9999710611431701 1.300299054654452 0.9180781957419593 0.04228707265172365 1.2549509256406259e-05 2.4054044848554085e-06 0.04094824359558401 0.013648094008319407 7.535895038344942e-11 10.122865159125086 0.3003279935112818 FGGALDAAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGGALDAAAK 10 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 10324750.0 2326600.0 880950.0 7117200.0 False True 2252743.3565164534 1232717.9290935593 5252991.808576713 1.0 0.5472074417743625 2.3318199089929696 21.103251533420817 -6.839443936424964 1.2849948183138358 0.7591079088355027 2.38986699288316 0.9234923675513929 0.20951142859337088 0.16944793516379475 0.543747228589752 0.12786089330312334 0.2945210136071898 1.4472916735858536e-07 6.839443936424964 1.6307590840476576 up FGGALDAAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGGALDAAAK 10 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 11455400.0 2690400.0 4270500.0 4494500.0 False True 3685113.585326225 4081815.1893449826 3432991.667133095 1.0 1.1076497629810886 0.9315836778553975 21.813277657155073 -6.741226384734048 1.6820787746278312 1.0639589958580458 0.9314497740098654 0.6105064809943757 0.045228784185136574 0.31559357062708615 1.7537277952533248 0.021267011215739935 0.0521198216724364 1.8145695353322156e-07 6.741226384734048 -0.13250922184818037 FGGALDAAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGGALDAAAK 10 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 4556500.0 2326600.0 1063700.0 1166200.0 False True 1934670.985856043 1057969.6369720823 1410047.0281004324 1.0 0.5468473165239295 0.7288303997987142 20.883656808855093 -10.154265736526467 5.296829326608676 1.0000120002916606 0.6378388581611578 0.84077865757989 0.07429428264084792 1.0528833977479079e-05 1.6809928509707264e-06 0.07193751226419894 0.023978376615453035 7.01026222560478e-11 10.154265736526467 -0.3621731421305028 FGGK(ub)ELRDEEQTAESIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGGKELRDEEQTAESIK 17 2 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 40470800.0 10233800.0 7938500.0 22298500.0 True False 15525422.790996186 6521812.651216397 17891191.701220248 1.0 0.42007311098791184 1.1523803211076522 23.888129220912894 -6.695660976059945 1.8464097788894103 0.6383641550746517 1.1500277503005587 0.3969679777101235 0.24499464789367262 0.4046266924325877 2.6787421649859597 0.10598093819081843 0.27401761238046485 2.0152968401116776e-07 6.695660976059945 0.511663595225907 FGGK(ub)ELRDEEQTAESIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGGKELRDEEQTAESIK 17 2 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 44759300.0 10233800.0 9885500.0 24640000.0 True False 13247855.838356623 9335363.234947106 20155772.82775012 1.0 0.7046697479843005 1.5214366063218283 23.659255543005344 -6.808880488320991 1.41904962331779 0.8388250448151624 1.5353847073770952 0.8569007629806791 0.1277375341944358 0.2083507928515405 0.827089917296902 0.07078071688982607 0.16382897909341088 1.552814263620042e-07 6.808880488320991 0.6965596625619328 FGGLVLSPVGK(ub)QYASPADR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGGLVLSPVGKQYASPADR 19 1 Q9UJK0 Q9UJK0 TSR3 Ribosome biogenesis protein TSR3 homolog 1 15537400.0 5066400.0 7999100.0 2471900.0 True False 6642099.463087387 6805665.460247592 2216131.500139117 1.0 1.0246256470667447 0.3336492493758912 22.66320789617391 -6.898633255721532 0.9698444669046583 1.0298155075355626 0.2630937433980375 0.9858746743592596 0.038041868048555944 0.11241914139255457 0.18313771897248304 0.02949210478726926 0.07622246750652117 1.2628935473943137e-07 6.898633255721532 -0.7667217641375251 down FGGLVLSPVGK(ub)QYASPADR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGGLVLSPVGKQYASPADR 19 1 Q9UJK0 Q9UJK0 TSR3 Ribosome biogenesis protein TSR3 homolog 1 27966400.0 12701000.0 11671000.0 3594400.0 True False 12297813.707175903 16331291.163460989 2652918.810311376 1.0 1.32798329461858 0.21572280028631188 23.55189852171347 -6.827732294282662 1.3380226415901642 1.1755457295577083 0.18715724489407068 0.9012615435865587 0.1466311927810076 0.18362553347796773 0.64373634275978 0.08606397235237724 0.1980839191267949 1.4868518779560767e-07 6.827732294282662 -0.9883884846636376 down FGGLVLSPVGK(ub)QYASPADR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGGLVLSPVGKQYASPADR 19 1 Q9UJK0 Q9UJK0 TSR3 Ribosome biogenesis protein TSR3 homolog 1 14070300.0 5066400.0 6812700.0 2191200.0 True False 6939584.994311908 6511692.38741379 1673683.689180559 1.0 0.938340317576794 0.24117921900984116 22.7264179576968 -6.924272458882363 0.7924093632236382 1.0131463826992244 0.1169179533849784 0.9952873666749916 0.023622003500625523 0.09572324022492348 0.09306714560523296 0.020827533679830514 0.06518037315137687 1.190494905101605e-07 6.924272458882363 -0.896228429314246 down FGGLVLSPVGK(ub)QYASPADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGGLVLSPVGKQYASPADR 19 1 Q9UJK0 Q9UJK0 TSR3 Ribosome biogenesis protein TSR3 homolog 1 22980700.0 14072000.0 2724300.0 6184400.0 True False 18216481.400589682 2572690.310147832 5058902.657302664 1.0 0.1412287177514178 0.27771019803741587 24.118740986900296 -10.351750841340476 7.4090053087169645 1.0000124461997884 0.2094694618633302 0.9781339792693418 0.05571833100673623 1.1455249521334179e-05 1.0022788130852526e-06 0.053949889295380415 0.017983014005630193 4.4488642962311595e-11 10.351750841340476 -0.7905429843364582 FGGPEMYGYPDPSYLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGGPEMYGYPDPSYLKR 17 1 Q8TDB6;Q8TDB6-2 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 9297700.0 2302500.0 4034900.0 2960300.0 True False 3018599.7974417144 3432908.6479170155 2653996.5532027283 1.0 1.1372519970439376 0.8792144475236532 21.525448067971656 -6.7621977663434105 1.6041007192272907 1.0795060902600535 0.8781651281549399 0.6998926164980155 0.057748429978759584 0.27925102892120174 1.416653478641613 0.028397462066421533 0.0680989441154227 1.7290288254318348e-07 6.7621977663434105 -0.20134096210511365 FGGPEMYGYPDPSYLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGGPEMYGYPDPSYLKR 17 1 Q8TDB6;Q8TDB6-2 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 18787700.0 5250700.0 6545000.0 6992000.0 True False 5084019.40258787 9158452.631724115 5160585.444496207 1.0 1.8014196851928368 1.0150601395953294 22.277538105560808 -10.259327735172675 4.93499123880792 0.9999096965537994 1.4082399123944245 0.2643586240000254 0.3210299401813034 0.0003190314776319878 4.788236984946524e-05 0.31090432970668347 0.10361196766284404 5.5039219271640555e-11 10.259327735172675 0.4083302158406251 FGGPEMYGYPDPSYLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGGPEMYGYPDPSYLKR 17 1 Q8TDB6;Q8TDB6-2 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 49824300.0 8688500.0 9710800.0 31425000.0 True False 13181089.714433597 7977831.869173297 25213834.975933217 1.0 0.6052482793161924 1.912879399365857 23.651966310780697 -6.8257319174677615 1.3467405181583516 0.7883635482422606 1.9451293444955862 0.8970898609645105 0.17567722143002132 0.18613783978364912 0.6617173484369399 0.10245988557181267 0.23588994869662092 1.4937161704196033e-07 6.8257319174677615 1.1567657962533255 FGGPEMYGYPDPSYLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGGPEMYGYPDPSYLKR 17 1 Q8TDB6;Q8TDB6-2 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 8649600.0 2302500.0 3486000.0 2861100.0 True False 3153796.4727228726 3331976.9933395674 2185367.1062041367 1.0 1.0564971526088556 0.6929321930268286 21.588658129494547 -6.867203251356808 1.148703796397183 1.0314749094984061 0.6727343679486869 0.9618157997472874 0.031215133923548823 0.1395692405552179 0.3459410839130396 0.02112217983200047 0.049781833796757345 1.3576778998105297e-07 6.867203251356808 -0.35874054154971924 FGGPEMYGYPDPSYLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGGPEMYGYPDPSYLKR 17 1 Q8TDB6;Q8TDB6-2 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 16581300.0 5250700.0 5672600.0 5658000.0 True False 4366189.69545015 5642040.577877061 6841061.640363795 1.0 1.2922115096731663 1.5668264820222126 22.057943380995084 -6.971875410923169 0.20858612000699567 0.8536041368309761 2.0130879069198273 0.9999935498842771 0.0005877695123249624 0.07569872283136618 0.006807768076848458 0.008316524523985668 0.028550584467588326 1.066902146967296e-07 6.971875410923169 1.1594837700888512 FGGPEMYGYPDPSYLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGGPEMYGYPDPSYLKR 17 1 Q8TDB6;Q8TDB6-2 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 56331500.0 8688500.0 12910000.0 34733000.0 True False 11247434.525939697 12191547.151197946 28411950.390675455 1.0 1.0839402641625397 2.526082754707274 23.423092632873146 -6.918854005726807 0.8331817017150436 0.9668466844589216 2.7526199986234836 0.9938566201326895 0.0549015546340879 0.09885082893142316 0.10914279633492936 0.04701845497090223 0.13933608614252715 1.2054410984554042e-07 6.918854005726807 1.785773314164562 up FGGSYIVQGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGGSYIVQGLK 11 0 Q9UNS1-2;Q9UNS1 Q9UNS1-2 TIMELESS Protein timeless homolog 0 4254310.0 809710.0 1619600.0 1825000.0 False True 1061537.6512427938 1377961.9931513518 1636166.5066361455 1.0 1.2980811293298025 1.5413174508889118 20.017724111832596 -6.973444770886065 0.15520508598695154 0.7370104411381723 2.1088144617157947 0.999998307545945 0.0002879315845153912 0.07519992133275565 0.004768072691874022 0.011792003511338208 0.029722160566357313 1.0630537629448612e-07 6.973444770886065 1.3718040205776223 FGGVVELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGGVVELR 8 0 P49247 P49247 RPIA Ribose-5-phosphate isomerase 0 7751600.0 3276900.0 1159500.0 3315200.0 False True 4296047.633544744 986507.1196955997 2972174.9056439186 1.0 0.2296313271744651 0.6918393740414663 22.034578558992425 -10.322746145594905 5.6125956422286345 1.0000852412716117 0.4607353506175726 0.6447554698113784 0.18869564497211458 0.0002013008621835379 2.4290222025425195e-05 0.18273243025466612 0.060901257539902644 4.756131507583728e-11 10.322746145594905 -0.539349890654039 FGGVVELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGGVVELR 8 0 P49247 P49247 RPIA Ribose-5-phosphate isomerase 0 4362140.0 1959700.0 1536900.0 865540.0 False True 1629577.379430106 1528620.4146492365 1046520.4121952056 1.0 0.9380471488772285 0.6422035709413159 20.63606642847005 -6.940836403153328 0.6517395837947112 1.0032788396349552 0.5604229239949586 0.9982713616640893 0.00649126029411596 0.08738724306506739 0.05288828562921523 0.006359516674096942 0.025370316467472905 1.1459445324836522e-07 6.940836403153328 -0.4428559156399966 FGHEFLEFEFRPDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGHEFLEFEFRPDGK 15 1 P61326;Q96A72;P61326-2;F5H6N1 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 0 6861300.0 2202600.0 1473500.0 3185200.0 False True 2132679.6686422816 2061876.2342009894 2350900.5660482417 1.0 0.9668007176687873 1.1023223977864829 21.02423585653733 -6.841925064140173 1.2733224067009905 0.9823397435893474 1.1069550285653655 0.9277207258604824 0.015505950298626663 0.16657028233421448 0.523760867117892 0.009545220361036968 0.022004270391107198 1.4390468588934464e-07 6.841925064140173 0.12461528497601815 FGHEFLEFEFRPDGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGHEFLEFEFRPDGK 15 1 P61326;Q96A72;P61326-2;F5H6N1 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 0 22332200.0 2958100.0 14370000.0 5004100.0 False True 4487653.9660776835 11805561.226677535 4015037.441625053 1.0 2.6306754745165604 0.8946851677903079 22.09753000626237 -6.6602813251524315 1.9715774630689298 2.0494245943016427 0.9018885271683009 0.2367832146490244 0.6942633467735072 0.4838769592511226 3.615929878632096 0.28444460622000095 0.7697966501692297 2.1863449053469077e-07 6.6602813251524315 -1.1475360671333417 FGHEFLEFEFRPDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGHEFLEFEFRPDGK 15 1 P61326;Q96A72;P61326-2;F5H6N1 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 0 6233800.0 1502600.0 2328900.0 2402300.0 False True 2058151.8262381742 2226001.4973575803 1834926.2169215332 1.0 1.081553590449251 0.8915407471543798 20.972917980555877 -6.790056720822121 1.4959551655511851 1.0455766795405115 0.8895123827070393 0.8015573094749683 0.034671397149890974 0.23526475408521555 1.0400840113356715 0.01824218488145118 0.042710435352644065 1.6215982954619231e-07 6.790056720822121 -0.15606429683347223 FGHLGLAINLITYDDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGHLGLAINLITYDDR 16 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 107249000.0 30064000.0 44066000.0 33119000.0 False True 45609285.97280677 36202078.01077055 26573015.133426644 1.0 0.7937435817862838 0.5826229147562197 25.44282424875594 -6.970834294075121 0.23742449089623013 1.0782704730878676 0.292009104015278 0.9999881752176973 0.0005859199718385103 0.07603296115334857 0.008055579600056333 0.005139923499287422 0.02067775799462081 1.0694628570692921e-07 6.970834294075121 -0.7862613690725896 FGHLGLAINLITYDDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGHLGLAINLITYDDR 16 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 69506000.0 30064000.0 19330000.0 20112000.0 False True 38918440.65003752 18254268.50756438 16451822.36654665 1.0 0.46903905199364104 0.4227256306203211 25.21395057084839 -13.999999999999998 0.3453712604114501 7.346294502603217 0.4159294403405697 0.999745791698842 0.004175657856953555 20.207737864762628 0.18886260329299887 93.87619209996397 0.014040669364017084 1.0000000000000041e-14 13.999999999999998 -6.930365062262648 FGHLGLAINLITYDDRFNLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGHLGLAINLITYDDRFNLK 20 1 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 196792900.0 40912900.0 59620000.0 96260000.0 False True 62067860.43363645 48980345.186813906 77234168.80774312 1.0 0.7891418335449819 1.2443504298061414 25.8873430792625 -6.780753083407214 1.5329784481718878 0.880724184732954 1.248039442945366 0.7700377409898068 0.08919789223599939 0.24940291556489474 1.1577195371541276 0.04582673459923524 0.10806208934888414 1.656711613290846e-07 6.780753083407214 0.36731525821241207 FGHLGLAINLITYDDRFNLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGHLGLAINLITYDDRFNLK 20 1 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 121370600.0 40912900.0 38053000.0 42404700.0 False True 52962555.56382784 35935317.09872465 34687479.70896491 1.0 0.678504213328928 0.6549434659957313 25.65846940135495 -13.999999999999998 0.37086699100723564 5.502662835095612 0.6525340572669944 0.9997923804664426 0.002268000238071983 22.921308415484347 0.19774625292047823 82.08214788434498 0.0065669187383723005 1.0000000000000041e-14 13.999999999999998 -4.850128777828617 FGIEK(ub)EVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGIEKEVR 8 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 20488500.0 5496400.0 9147100.0 5845000.0 True False 7205833.627213317 7782388.335116534 5240215.469199057 1.0 1.0800122147874494 0.7272184927235941 22.780733911629373 -6.847108664167034 1.2490318535979323 1.042612967582687 0.7138878246698983 0.9359812436150796 0.038212065188596496 0.16066712107244327 0.4838115614334194 0.0239566157807368 0.05534200354538847 1.4219729529012961e-07 6.847108664167034 -0.32872514291278865 FGIEK(ub)EVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGIEKEVR 8 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 89350200.0 18866000.0 39525000.0 30959200.0 True False 28621101.289348435 32471454.939765476 24840100.550100625 1.0 1.1345284939070455 0.8678946452471087 24.770575849697277 -6.769542967241365 1.5762956737989617 1.0772071463442723 0.8664240233416353 0.7287796389341433 0.05669004183221053 0.26716743555400546 1.3100438734671256 0.028349541047251934 0.06750945755280245 1.7000317514404684e-07 6.769542967241365 -0.21078312300263702 FGIEK(ub)EVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGIEKEVR 8 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 39130000.0 18866000.0 0.0 20264000.0 True False 24422408.904457387 0.0 16576159.926198356 1.0 0.0 0.6787274748795564 24.541702171789726 -10.428762281727167 8.05553457879293 1.000016532449682 0.33936374065480945 0.5581480830646042 0.27708933131043345 8.227453615990618e-05 5.8341220685232645e-06 0.2682972784795343 0.08943019713142154 3.725955968149212e-11 10.428762281727167 -0.6606527917948725 FGIIMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGIIMR 6 0 O43719;Q5H918;Q5H919;K7ERC0 O43719 HTATSF1;CFAP52 HIV Tat-specific factor 1 0 23061500.0 6449800.0 7702900.0 8908800.0 False True 8455750.259952053 6553657.345669033 7987002.8352438975 1.0 0.7750533239739029 0.9445646559681135 23.011501336767413 -10.499293469368682 4.962563756045929 1.0004591262073168 0.8598089899710016 0.47697983748887063 0.06920271150091149 0.00035267214164925255 3.5583397261718883e-05 0.06722285050292205 0.022335079096282313 3.1674263887359034e-11 10.499293469368682 -0.14065013623631517 FGIIMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGIIMR 6 0 O43719;Q5H918;Q5H919;K7ERC0 O43719 HTATSF1;CFAP52 HIV Tat-specific factor 1 0 18183100.0 4212900.0 2457200.0 11513000.0 False True 4079163.795524874 3438372.7741287183 8497399.917403422 1.0 0.8429111814291086 2.0831229985728106 21.959842007870897 -6.875114710931134 1.1066445049127898 0.9077093992379422 2.1631931730270892 0.969528428118496 0.09624559485990852 0.13204732163942856 0.2991638020816851 0.06726240063980474 0.16082567260381797 1.3331692534199153e-07 6.875114710931134 1.2554837737891469 up FGIIMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGIIMR 6 0 O43719;Q5H918;Q5H919;K7ERC0 O43719 HTATSF1;CFAP52 HIV Tat-specific factor 1 0 6023100.0 2247600.0 2057700.0 1717800.0 False True 3409773.521569997 1690487.358116519 1378276.0770615123 1.0 0.49577702079701486 0.4042133790829892 21.701244487412723 -13.999999999999998 0.23993634181089127 4.336444641979878 0.36370429031767154 0.9995248560160156 0.005710051253653186 13.62115376836404 0.1550332296544203 21.774153164298845 0.044758164805535704 1.0000000000000041e-14 13.999999999999998 -3.972740351662207 FGIIMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGIIMR 6 0 O43719;Q5H918;Q5H919;K7ERC0 O43719 HTATSF1;CFAP52 HIV Tat-specific factor 1 0 19200200.0 6449800.0 5702300.0 7048100.0 False True 8834465.359291213 5450353.531015556 5383483.940175937 1.0 0.6169420909306544 0.6093729185902713 23.074711398290304 FGIIMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGIIMR 6 0 O43719;Q5H918;Q5H919;K7ERC0 O43719 HTATSF1;CFAP52 HIV Tat-specific factor 1 0 9750600.0 4212900.0 3219700.0 2318000.0 False True 3503213.013114814 3202354.837039589 2802683.082778944 1.0 0.9141193598708053 0.800032162556679 21.740247283305173 -6.9671977589295615 0.3180977099898263 1.01597713224525 0.6945049275006412 0.9999515287340376 0.0005702166041033856 0.0772230419725792 0.012271488892020703 0.0017428681779788613 0.010052410604586677 1.07845552838542e-07 6.9671977589295615 -0.3214722047446088 FGIK(ub)AAEEQLSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGIKAAEEQLSAR 13 1 Q96CS2;Q96CS2-2 Q96CS2 HAUS1 HAUS augmin-like complex subunit 1 1 11184600.0 2431600.0 2982800.0 5770200.0 True False 2354410.188990546 4173847.5950965155 4258811.517710525 1.0 1.7727784285906671 1.8088655654079084 21.16693426016327 -11.179418740755125 0.5206582420587391 2.654952801468097e-11 1.8065864737240138 0.9998499259093758 0.004570501551007124 3.274989086955011 0.2547364741444409 3.829599895862114 0.007071944523344436 6.615783113914097e-12 11.179418740755125 1.8065864736974644 FGIK(ub)AAEEQLSAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGIKAAEEQLSAR 13 1 Q96CS2;Q96CS2-2 Q96CS2 HAUS1 HAUS augmin-like complex subunit 1 1 42401200.0 2639300.0 8096900.0 31665000.0 True False 4004011.058675789 6651944.933631557 25406398.870737493 1.0 1.6613203200871018 6.345236938266581 21.93301452808217 -6.932434614618258 0.7265291622902023 0.9348090188422328 7.369287942103639 0.9969954767929904 0.1304157369864143 0.09139330368046981 0.07163050838856112 0.12058444578017954 0.41828480006255103 1.1683296149594685e-07 6.932434614618258 6.4344789232614055 up FGIK(ub)AAEEQLSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGIKAAEEQLSAR 13 1 Q96CS2;Q96CS2-2 Q96CS2 HAUS1 HAUS augmin-like complex subunit 1 1 7723900.0 2431600.0 2909900.0 2382400.0 True False 2021983.1381447394 2894223.791130076 2880548.8250269857 1.0 1.4313787966529024 1.4246156511819474 20.947339535597546 -10.14609621082198 4.900212488161354 0.9999720022980825 1.427997223918962 0.9998127605343711 0.0027610425819977105 1930695.8714782489 0.03357667874622596 609.9265924199111 0.0009451783144402569 7.143380586604353e-11 10.14609621082198 0.4280252216208795 FGIK(ub)AAEEQLSAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGIKAAEEQLSAR 13 1 Q96CS2;Q96CS2-2 Q96CS2 HAUS1 HAUS augmin-like complex subunit 1 1 39563900.0 2639300.0 8557600.0 28367000.0 True False 3416625.8783809217 8081362.037265025 23204497.069999497 1.0 2.365304930926367 6.791641196897945 21.704140850174618 -6.949694625269511 0.5621855521030588 0.9427581008758165 8.42652509935873 0.9991771052298316 0.07091379567456726 0.08360858696464837 0.036471542820405455 0.07581644511438249 0.36812580570353526 1.1228076804793894e-07 6.949694625269511 7.483766998482914 FGILIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGILIGR 7 0 C9JFV4;Q8IZL8;E7EV54 C9JFV4 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 0 17351600.0 4586200.0 5483800.0 7281600.0 False True 6012552.612823976 4665638.415684981 6528169.882039331 1.0 0.7759829669903917 1.0857567995522586 22.519546182560806 -6.712702493764876 1.785592220843377 0.8626619920903077 1.0850882706998557 0.4779391570935887 0.09436049771543037 0.3696587811023537 2.299106682252429 0.04202815340188118 0.10642199828601964 1.937748932168037e-07 6.712702493764876 0.222426278609548 FGILIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGILIGR 7 0 C9JFV4;Q8IZL8;E7EV54 C9JFV4 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 0 14289100.0 4723700.0 2576800.0 6988600.0 False True 4573748.729122656 3605729.6778344805 5158076.006494013 1.0 0.7883532505569315 1.1277567509668251 22.124945679016452 -6.73808577667033 1.6936618239057748 0.8737907095942706 1.1278747229792687 0.5962975176930296 0.0889301446962032 0.32131023891910665 1.808955999549745 0.04155094236034526 0.10217900538781671 1.8277391872288043e-07 6.73808577667033 0.2540840133849981 FGILIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGILIGR 7 0 C9JFV4;Q8IZL8;E7EV54 C9JFV4 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 0 18930500.0 4586200.0 6334600.0 8009700.0 False True 6281842.077394854 6054716.426279062 6117973.824949584 1.0 0.9638441004537346 0.973913980895039 22.582756244083697 -10.226329308087319 5.336196395999521 1.0000023152243116 0.9688790416064815 0.9271927195341328 0.004111011475354812 1.1324328796569611e-07 1.6419795647981526e-08 0.003980765887558262 0.0013268232483406811 5.938417015104124e-11 10.226329308087319 -0.031123273617830072 FGILSNCNHTYCLSCIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGILSNCNHTYCLSCIR 17 0 C9J494;Q9H000-2;Q9H000 C9J494 MKRN2 Probable E3 ubiquitin-protein ligase makorin-2 0 6739200.0 1629300.0 2251800.0 2858100.0 False True 2231696.2401769287 2152308.0302931825 2183075.6444171984 1.0 0.9644269643625638 0.9782136139836506 21.089709242273845 -10.053050739230432 4.2205369439372635 1.0000027467389747 0.9713202891653496 0.8522879243511979 0.005628376164968853 1168668.0923337243 2783693.2379916864 15.280234433274126 0.001926742542006003 8.850122065793417e-11 10.053050739230432 -0.028682457573625086 FGIQAQMVTTDFQK ddPTM_RPMI8226_Bortezomib_1h_R1 2 FGIQAQMVTTDFQK 14 0 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 23679500.0 9109000.0 9419300.0 5151200.0 False True 11941987.211681472 8013977.156143835 4618203.237799515 1.0 0.6710756772796309 0.38671982777556974 23.509539593099646 -7.3659979253727865 0.21774200224512788 1.161455773985497 1.1624897788722799e-11 0.999957254821936 0.001638347798233883 0.11543324690989247 0.015868880081536103 0.021499153191742063 0.053295873258572275 4.305286671246932e-08 7.3659979253727865 -1.161455773973872 down FGIQAQMVTTDFQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGIQAQMVTTDFQK 14 0 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 34617000.0 14714000.0 8622000.0 11281000.0 False True 14246912.124036383 12064809.563136028 8326167.677254243 1.0 0.8468368063266941 0.5844191081383117 23.764145927623773 -6.962953724413379 0.391587129713927 1.0158344608850527 0.4059684981167157 0.999864551817242 0.0019971497140997196 0.07866238382133788 0.01735240977422692 0.003385273660837565 0.022059379556078923 1.0890461288017973e-07 6.962953724413379 -0.6098659627683369 FGIQAQMVTTDFQK ddPTM_RPMI8226_Bortezomib_8h_R1 2 FGIQAQMVTTDFQK 14 0 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 125798000.0 29137000.0 56319000.0 40342000.0 False True 44202959.20002896 46268434.42764459 32368386.01747327 1.0 1.0467270803809503 0.7322674002660904 25.397639619355402 -6.869100511401809 1.1389217641072598 1.0262857734791138 0.7141693483009861 0.963773117157845 0.026369509966016096 0.13771608021161041 0.3344452262771009 0.017979044408083462 0.04249850619773028 1.3517596810610258e-07 6.869100511401809 -0.31211642517812765 FGIQAQMVTTDFQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGIQAQMVTTDFQK 14 0 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 23284700.0 7679000.0 8723700.0 6882000.0 False True 10518133.817172201 8338258.088581865 5256613.339239059 1.0 0.7927507135313862 0.4997667295938909 23.32637542097665 -6.9662234905072635 0.33639352090558233 1.0331356944631371 0.24969802623924556 0.9999361885398401 0.001639303777602698 0.07754819218363784 0.013409338488457568 0.004183111941007973 0.025427265680368853 1.080877582162539e-07 6.9662234905072635 -0.7834376682238916 down FGIQAQMVTTDFQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGIQAQMVTTDFQK 14 0 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 26287000.0 14714000.0 6590000.0 4983000.0 False True 12235342.940722847 6554498.361987419 6024922.261211165 1.0 0.5357020554096695 0.49241956603916986 23.54455120305805 -13.999999999999998 0.3356821784144453 6.230857956384279 0.48525494419864185 0.9997265110406551 0.0037995597466525827 19.31463626259956 0.18559028624738208 71.53702286566536 0.013582426001926814 1.0000000000000041e-14 13.999999999999998 -5.7456030121856365 FGIQAQMVTTDFQK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FGIQAQMVTTDFQK 14 0 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 109672100.0 29137000.0 56561100.0 23974000.0 False True 37718420.876135685 53413425.06379716 19610977.994013004 1.0 1.41610978994064 0.5199310453216985 25.16876594144785 -6.780454415719359 1.5341680475132298 1.235471725449281 0.5127387801072703 0.7689770290770475 0.17600093024428468 0.2498665657573386 1.1616588524406328 0.09035522245824698 0.21311347240927614 1.6578513385870708e-07 6.780454415719359 -0.7227329453420108 FGIVTSSAGTGTTEDTEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGIVTSSAGTGTTEDTEAK 19 0 P82979;H0YHG0 P82979 SARNP SAP domain-containing ribonucleoprotein 0 18984900.0 3873400.0 9082200.0 6029300.0 False True 5078064.910058959 7727171.162138311 5405445.873129492 1.0 1.5216763273017309 1.064469629449209 22.27584740558995 -10.316571561937751 3.7419997637660125 0.9991914528631322 1.2930729783972301 0.35394438439535103 0.1866538530551893 133762338.9847605 194071698.2782307 1177770.5856764184 0.06830830559023254 4.8242348099851774e-11 10.316571561937751 0.29388152553409796 FGIVTSSAGTGTTEDTEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGIVTSSAGTGTTEDTEAK 19 0 P82979;H0YHG0 P82979 SARNP SAP domain-containing ribonucleoprotein 0 9656300.0 3247200.0 1139500.0 5269600.0 False True 3144119.4134274144 1594508.2924139998 3889333.6753886146 1.0 0.5071398642190315 1.2370184347256836 21.584224581414322 -6.724849632294069 1.7423225374160705 0.7017064568763107 1.2361677416912715 0.5351139311978361 0.20728338493466258 0.3459682748695407 2.055094988556122 0.09438048598443738 0.23554873290460862 1.8843013865913033e-07 6.724849632294069 0.5344612848149608 FGIVTSSAGTGTTEDTEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGIVTSSAGTGTTEDTEAK 19 0 P82979;H0YHG0 P82979 SARNP SAP domain-containing ribonucleoprotein 0 15561100.0 3873400.0 6528200.0 5159500.0 False True 5305500.65469915 6239762.538129483 3940932.3632379966 1.0 1.176093067221252 0.7428012207947732 22.33905746711284 -6.79637130075429 1.4706228413397575 1.0976115938894895 0.7373390617401999 0.8213408601470913 0.07520365763346352 0.2259892800661947 0.9652441066850904 0.04023622363261234 0.09379148763672149 1.5981910683735266e-07 6.79637130075429 -0.36027253214928956 FGIYDIDNK(ub)TPELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGIYDIDNKTPELR 14 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX45;Q5JX52;Q5JX61;Q5JX55;Q5JX54;E7EV27;Q5JX57 Q99829 CPNE1 Copine-1 1 17162100.0 4955900.0 2020200.0 10186000.0 True False 4798577.667222511 2826876.3952038256 7517981.026550107 1.0 0.5891071461681819 1.566710293740359 22.194175413381476 -6.7925049200581915 1.4862266627018035 0.7711098677544236 1.5778550815345092 0.8094140623620554 0.17496995241770255 0.23160592816761538 1.01056934736725 0.0926522171868705 0.21654029143369072 1.6124827596546836e-07 6.7925049200581915 0.8067452137800856 FGIYDIDNK(ub)TPELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGIYDIDNKTPELR 14 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX45;Q5JX52;Q5JX61;Q5JX55;Q5JX54;E7EV27;Q5JX57 Q99829 CPNE1 Copine-1 1 17355000.0 4955900.0 4170500.0 8228600.0 True False 4121050.43359579 4148032.6887205685 9949162.215252291 1.0 1.0065474217216108 2.414229666820949 21.974580688815752 -6.907920498590936 0.909779673674772 0.9534973789739194 2.5882834916134927 0.9901128737902162 0.06613719085578396 0.10580923821174151 0.14634536832598247 0.05359672204526504 0.14590387083959733 1.2361737051582158e-07 6.907920498590936 1.6347861126395733 up FGK(ub)ITNDFYPEEDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGKITNDFYPEEDGK 15 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 12581800.0 3058600.0 6162400.0 3360800.0 True False 4009854.2195245335 5242993.940847062 3013056.6550700045 1.0 1.307527319900609 0.7514130165628007 21.93511835697892 -6.7565965141054685 1.6253494582343295 1.1793829915904313 0.7497206293643722 0.6768999847905646 0.12929105664925647 0.2886700516139408 1.5021979832076198 0.06278828488051377 0.15139752321389457 1.7514731576767361e-07 6.7565965141054685 -0.429662362226059 FGK(ub)ITNDFYPEEDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGKITNDFYPEEDGK 15 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 13793300.0 4682100.0 4889300.0 4221900.0 True False 4533469.298351968 6841622.987362662 3116057.735714893 1.0 1.509136278886849 0.6873450619479566 22.11218408403583 -6.739139592277095 1.6900048273533212 1.3032349785939399 0.6869669063402362 0.6010316013677763 0.21392120294706884 0.3193621557475273 1.7906809763906615 0.1001547523045633 0.24598823853909696 1.8233095543214042e-07 6.739139592277095 -0.6162680722537037 FGK(ub)ITNDFYPEEDGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGKITNDFYPEEDGK 15 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 42854000.0 8778000.0 18384000.0 15692000.0 True False 13316867.757760031 15103231.565152397 12590469.321952078 1.0 1.1341429411095123 0.9454527559316894 23.666751452195527 -6.715746130661425 1.7745702028767445 1.0819746137610475 0.9458120186545903 0.4925490963526321 0.056478494822077466 0.3635693563325536 2.2351289573543753 0.025293988647642034 0.06381851908729799 1.924216211876335e-07 6.715746130661425 -0.13616259510645723 FGK(ub)ITNDFYPEEDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGKITNDFYPEEDGK 15 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 14327100.0 4682100.0 4543000.0 5102000.0 True False 3893373.602199166 4518525.957285103 6168804.611017325 1.0 1.1605682934545045 1.5844368512523137 21.892589359470108 -6.954285557471486 0.5096323168832844 0.9921754007138037 1.7714137361864895 0.9994960801310633 0.005534241915252386 0.08180922245376164 0.029183920257798913 0.006378415325313422 0.03498201548887169 1.1110009812836237e-07 6.954285557471486 0.7792383354726857 FGK(ub)ITNDFYPEEDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGKITNDFYPEEDGK 15 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 36426000.0 8778000.0 10718000.0 16930000.0 True False 11363294.040248442 10121533.878120799 13848913.716469523 1.0 0.8907218137866215 1.2187411209651964 23.437877774287976 -6.816900770351545 1.3853270159492101 0.9409094182846716 1.2254316365665197 0.8770852671322256 0.04781238020577232 0.19753952567143207 0.7457554727810245 0.027127835230464366 0.06257990988435098 1.524401016332542e-07 6.816900770351545 0.2845222182818481 FGK(ub)LSAFPEPPEDGTLLSEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGKLSAFPEPPEDGTLLSEAK 21 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 91489000.0 32988000.0 34607000.0 23894000.0 True False 31940813.996718246 48425755.573120914 17635444.595365025 1.0 1.5161090001681363 0.5521288404602643 24.9288977438381 -6.7612726239786145 1.6077383667032923 1.299308275434669 0.5483899016080813 0.6961359775718027 0.2171173395908481 0.2807760012878706 1.4306852765503102 0.10653871595934078 0.25570261446097675 1.7327159613277758e-07 6.7612726239786145 -0.7509183738265877 FGK(ub)LSAFPEPPEDGTLLSEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGKLSAFPEPPEDGTLLSEAK 21 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 68940000.0 13672000.0 41245000.0 14023000.0 True False 18726907.871907547 39422659.52102422 10711056.212750537 1.0 2.1051344829950605 0.5719607468576442 24.15860937019199 -6.713282348166119 1.7833718958877056 1.677116259663849 0.5751815380422811 0.4807346663313844 0.4654657412176265 0.36851742695955536 2.2866236048977036 0.20754214568008036 0.5251928234193847 1.9351634457666035e-07 6.713282348166119 -1.1019347216215678 FGK(ub)LSAFPEPPEDGTLLSEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGKLSAFPEPPEDGTLLSEAK 21 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 97809000.0 32988000.0 55175000.0 9646000.0 True False 27430983.616186306 54877761.32361993 11662934.001935154 1.0 2.000575775607186 0.4251737438628764 24.709303019272376 -6.735080947077585 1.7046174819991267 1.5986917247262185 0.4251857771188996 0.5827424390462834 0.4204757405431148 0.3267688865079675 1.8623150773933688 0.195295147010225 0.48186520435116037 1.8404289364871457e-07 6.735080947077585 -1.1735059476073189 FGK(ub)LSAFPEPPEDGTLLSEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGKLSAFPEPPEDGTLLSEAK 21 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 106019000.0 39021000.0 45017000.0 21981000.0 True False 50513453.71890347 42511764.37687663 17980683.544106126 1.0 0.8415929073756365 0.3559583085362718 25.590164349670868 -6.950962562398206 0.5481771728416853 1.0067898964755182 0.1680182410489933 0.9992746543655698 0.0073796474617434295 0.08310157045545774 0.034380841066759614 0.00802858479829144 0.04027381674388983 1.1195343868257299e-07 6.950962562398206 -0.8387716554265249 down FGLALAVAGGVVNSALYNVDAGHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGLALAVAGGVVNSALYNVDAGHR 24 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2;D6RBK0 P35232 PHB Prohibitin 0 305382900.0 71839000.0 116540000.0 117003900.0 False True 108985015.13439527 95742526.46882398 93878027.8803688 1.0 0.8784925739631153 0.8613847304108988 26.699554544766702 -13.999999999999844 0.2761724242685903 1.9697063037440508 0.856037261656465 0.9995967334936512 0.0012391760999604605 15.195076232366704 0.16642341286387377 8.303406136549453 0.006892786631167833 1.0000000000003599e-14 13.999999999999844 -1.1136690420875857 FGLALAVAGGVVNSALYNVDAGHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGLALAVAGGVVNSALYNVDAGHR 24 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2;D6RBK0 P35232 PHB Prohibitin 0 251492000.0 71839000.0 113632000.0 66021000.0 False True 92997001.65839677 107308279.3094442 54005855.43266597 1.0 1.1538896673638646 0.5807268457002962 26.47068086685915 -6.835235006475122 1.3042800545485609 1.0819810429942263 0.5635784153931681 0.9159572847990161 0.07021673871027317 0.17443813002413947 0.578464563301986 0.04224372197889421 0.09723516786364605 1.4613861716595032e-07 6.835235006475122 -0.5184026276010582 FGLCAYMSQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGLCAYMSQGR 11 0 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 0 36721000.0 13295000.0 10783000.0 12643000.0 False True 17429873.748963162 9174218.431804793 11334823.64021961 1.0 0.5263502515243711 0.6503101401347715 24.05505878373799 -10.208891033065939 8.042871604637998 1.0000001785505392 0.5883301958295868 0.9363272975492326 0.05060641261128685 1.6199489041770243e-07 1.5977661308347892e-08 0.04899946948748048 0.01633314943790125 6.18171483392404e-11 10.208891033065939 -0.41166998272095245 FGLCAYMSQGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGLCAYMSQGR 11 0 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 0 155591000.0 40298000.0 44013000.0 71280000.0 False True 61135012.17842492 36158536.27486148 57191476.75686615 1.0 0.5914538165025858 0.935494648957468 25.86549551609312 -10.05719005447371 7.142841675908268 1.0000000436049998 0.7634742327300269 0.38657684729652864 0.14045408169947018 9.752343170092926e-08 1.3050497788017697e-08 0.13599410414979476 0.0453313599440753 8.76617114992039e-11 10.05719005447371 -0.23652581087497293 FGLCAYMSQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGLCAYMSQGR 11 0 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 0 46554000.0 13295000.0 13880000.0 19379000.0 False True 18210520.783865657 13266735.704977958 14802079.323033089 1.0 0.728520390077595 0.8128311924032171 24.118268845260882 -10.341208820189053 8.08773769431347 1.000001077257797 0.7706757912404061 0.9079565327087639 0.034419740917071937 6.685713260952687e-07 5.446455854512864e-08 0.03332692725664372 0.011108923612716131 4.558176941371435e-11 10.341208820189053 -0.22932528601739088 FGLCAYMSQGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGLCAYMSQGR 11 0 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 0 12541890.0 6533500.0 715790.0 5292600.0 False True 5432894.733125779 711933.8971968099 6399258.189782504 1.0 0.1310413568030249 1.1778726634927335 22.37328966318254 -6.6862918798839495 1.8792018500462218 0.45335644218975635 1.1741428378356564 0.35333484036730123 0.36778635395054343 0.4246696739194688 2.9045174251695913 0.156726522582042 0.4101035162847203 2.0592454739612413e-07 6.6862918798839495 0.7207863956459001 FGLCAYMSQGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGLCAYMSQGR 11 0 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 0 205259000.0 40298000.0 99434000.0 65527000.0 False True 52166555.39233673 93900410.49048923 53601758.36379795 1.0 1.8000117083498903 1.0275119367316334 25.63662183818557 -10.429126302188719 4.918513517090585 0.9993559784291193 1.4137618225408168 0.2766779521794751 0.3153717111470688 0.002230544573547506 0.0002588901205578297 0.3058161896022258 0.10178578209476721 3.722834224725971e-11 10.429126302188719 0.41440584411169756 FGLESHAHTIQICK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGLESHAHTIQICK 14 0 Q8NE71-2;Q8NE71;H0YGW7;A0A0G2JIC2 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 33773300.0 6807600.0 6437300.0 20528400.0 False True 8924829.52489217 5476879.9323988715 18404318.09031752 1.0 0.6136677364114743 2.0621478582852686 23.08939318149767 -6.835750365714117 1.302022692121664 0.794241179002014 2.105907308689311 0.9168904858484423 0.1765523560148509 0.17382218112624753 0.5742392597222946 0.10639672177400789 0.24490345749400738 1.4596530338600288e-07 6.835750365714117 1.3116661296872971 up FGLESHAHTIQICK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGLESHAHTIQICK 14 0 Q8NE71-2;Q8NE71;H0YGW7;A0A0G2JIC2 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 14251600.0 6807600.0 5021700.0 2422300.0 False True 9324553.68847263 4799824.689458782 1850202.628834464 1.0 0.514751145182692 0.19842264741547416 23.15260324302056 -8.333163643501694 0.28182745565347933 1.176182353462546 1.0639897348995579e-14 0.999115623920899 0.009803454060780738 0.11063593613225192 0.06878704887572604 0.10033948081596919 0.09990751612801896 4.64340277404754e-09 8.333163643501694 -1.1761823534625353 down FGLNVSSISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGLNVSSISR 10 0 P82979;F8VZQ9;H0YHG0 P82979 SARNP SAP domain-containing ribonucleoprotein 0 208040000.0 60628000.0 58481000.0 88931000.0 False True 79483895.12238722 49755862.75715259 79729273.2063885 1.0 0.6259867194548004 1.0030871421641259 26.244159238058025 -10.972363748285048 10.554993267852456 1.094745146288344 0.8145369307896656 0.2438605205990778 0.15395060290428222 0.08280621716369121 0.0002168122472810901 0.035961022302814144 0.04968734343223967 1.0657031555213845e-11 10.972363748285048 -0.28020821549867836 FGLNVSSISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGLNVSSISR 10 0 P82979;F8VZQ9;H0YHG0 P82979 SARNP SAP domain-containing ribonucleoprotein 0 158936000.0 48970000.0 21256000.0 88710000.0 False True 47415474.15482281 29743631.64857568 65474189.75704502 1.0 0.6272979903450009 1.3808612256677262 25.49885462720012 -6.772216851411858 1.5658228380612977 0.7868305455313991 1.385472444964573 0.7389891703775409 0.15717440528648186 0.262876174625485 1.272256877540821 0.07910330517997277 0.18792955005165493 1.6895970733526e-07 6.772216851411858 0.5986418994331739 FGLNVSSISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGLNVSSISR 10 0 P82979;F8VZQ9;H0YHG0 P82979 SARNP SAP domain-containing ribonucleoprotein 0 194567000.0 51360000.0 80849000.0 62358000.0 False True 77916874.9189513 66420864.273879774 50032913.96751768 1.0 0.8524580117332784 0.6421319389357137 26.215432479345548 -6.966089740338041 0.3388314152715774 1.0231239141198454 0.4644887062322869 0.9999338746289856 0.0011941057814611237 0.07759310859525226 0.013566837668318869 0.0029797721153190086 0.018220291795230048 1.0812105125338701e-07 6.966089740338041 -0.5586352078875585 FGLNVSSISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGLNVSSISR 10 0 P82979;F8VZQ9;H0YHG0 P82979 SARNP SAP domain-containing ribonucleoprotein 0 167754000.0 60628000.0 52424000.0 54702000.0 False True 83043810.01009451 50107734.33701479 41782514.22305356 1.0 0.6033891548439778 0.5031382136486107 26.307369299580916 -13.999999999999998 0.19312008656091242 3.149493128510306 0.43343213950927684 0.9994879933382059 0.004854369720136715 12.40321283173061 0.13936082265596503 10.043380186301558 0.06727138569653861 1.0000000000000041e-14 13.999999999999998 -2.716060989001029 FGLNVSSISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGLNVSSISR 10 0 P82979;F8VZQ9;H0YHG0 P82979 SARNP SAP domain-containing ribonucleoprotein 0 115859000.0 48970000.0 39148000.0 27741000.0 False True 40720724.73883368 38937101.95373043 33541514.840108152 1.0 0.9561986483162397 0.823696411476709 25.279259902634397 -6.951263742394108 0.5447972990679129 1.001891560134555 0.7718340704692283 0.9992967299157391 0.0019876250442545863 0.08298230285140452 0.033893257365938165 0.002172038153305319 0.010981818820883733 1.1187582671955726e-07 6.951263742394108 -0.2300574896653268 FGLNVSSISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGLNVSSISR 10 0 P82979;F8VZQ9;H0YHG0 P82979 SARNP SAP domain-containing ribonucleoprotein 0 198956000.0 51360000.0 99619000.0 47977000.0 False True 66486532.45695596 94075115.07786117 39245678.28559117 1.0 1.4149499395049114 0.5902801189248245 25.986558801437997 -6.769929822148047 1.5749813282131846 1.238028177907214 0.5856821503108541 0.7301997064239513 0.17487534986630787 0.26654272860549894 1.3048856650120253 0.08752458258274187 0.2083362479847796 1.6985180946345352e-07 6.769929822148047 -0.6523460275963598 FGLSVGHHLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGLSVGHHLGK 11 0 B4DLR8;H3BNV2;P15559-3;P15559-2;P15559 B4DLR8 NQO1 NAD(P)H dehydrogenase [quinone] 1 0 57223800.0 24641000.0 17533000.0 15049800.0 False True 32304589.623783417 14917144.743098699 13492591.063875427 1.0 0.4617654926690769 0.41766792957313587 24.945235812322228 -13.999999999999998 0.35452248863656727 7.806747397768035 0.41193526051785656 0.9997632301005525 0.004073528333606717 21.118608341689413 0.1920044715958296 108.48637162839445 0.012957606298074426 1.0000000000000041e-14 13.999999999999998 -7.394812137250178 FGLSVGHHLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGLSVGHHLGK 11 0 B4DLR8;H3BNV2;P15559-3;P15559-2;P15559 B4DLR8 NQO1 NAD(P)H dehydrogenase [quinone] 1 0 52076400.0 10172000.0 5886300.0 36018100.0 False True 9849095.427871287 8236730.286648989 26583879.090161428 1.0 0.8362930735080935 2.6991188464814253 23.231559798294096 -6.8854874104678405 1.048748416867524 0.8888140566608893 2.8458381173913163 0.9778477292448319 0.12535213845491042 0.12287917856559322 0.24386819610688681 0.09157177874331003 0.22487146934243085 1.3017050494689134e-07 6.8854874104678405 1.957024060730427 up FGLSVGHHLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGLSVGHHLGK 11 0 B4DLR8;H3BNV2;P15559-3;P15559-2;P15559 B4DLR8 NQO1 NAD(P)H dehydrogenase [quinone] 1 0 36321400.0 12191400.0 10263000.0 13867000.0 False True 18495245.11072632 8431487.464815015 11126181.371877981 1.0 0.4558732481963796 0.6015698253939523 24.140651084310434 -10.433851632462257 9.115941229966007 1.000003253136959 0.5287215367952381 0.9331133878481664 0.05948037856734531 3.932622525727853e-06 2.4429878571722205e-07 0.05759202597472455 0.019197209634786744 3.6825475861641315e-11 10.433851632462257 -0.4712817163417208 FGLSVGHHLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGLSVGHHLGK 11 0 B4DLR8;H3BNV2;P15559-3;P15559-2;P15559 B4DLR8 NQO1 NAD(P)H dehydrogenase [quinone] 1 0 54491580.0 24641000.0 11502180.0 18348400.0 False True 33751443.597986676 10993975.654977208 14014885.817159813 1.0 0.32573349412624875 0.41523811497046076 25.00844587384512 -10.721772311164115 6.906514389353502 1.0075408782483104 0.37048580455154057 0.985064973084583 0.0365401084482658 0.004232688024549159 0.0001705128557679778 0.03529548285512007 0.011793269290728856 1.89770057347345e-11 10.721772311164115 -0.6370550736967698 FGLSVGHHLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGLSVGHHLGK 11 0 B4DLR8;H3BNV2;P15559-3;P15559-2;P15559 B4DLR8 NQO1 NAD(P)H dehydrogenase [quinone] 1 0 25298500.0 10172000.0 7244600.0 7881900.0 False True 8458468.696006035 7205571.901859489 9529968.84821197 1.0 0.8518766411303094 1.1266777936663501 23.011965073728373 -6.760305697514628 1.6113571626195635 0.9139944358381062 1.1276957133791137 0.6922054830046975 0.062303686688827714 0.2824014790152564 1.4452360434812772 0.030506490771236718 0.07328867005842202 1.736578030645097e-07 6.760305697514628 0.21370127754100743 FGLSVGHHLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGLSVGHHLGK 11 0 B4DLR8;H3BNV2;P15559-3;P15559-2;P15559 B4DLR8 NQO1 NAD(P)H dehydrogenase [quinone] 1 0 61612400.0 12191400.0 34035000.0 15386000.0 False True 15782007.628421606 32140922.3308305 12585905.873691665 1.0 2.0365547329319713 0.7974844626881231 23.911777406402884 -6.684737382318704 1.885095250258395 1.6530019743177156 0.8020048500177654 0.3460700717851969 0.438863048129701 0.42799541443821587 2.9444730734551263 0.18653473638295148 0.4890000050854192 2.0666294679692612e-07 6.684737382318704 -0.8509971242999501 FGLYLPLFKPSVSTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGLYLPLFKPSVSTSK 16 1 Q9UJS0;Q9UJS0-2 Q9UJS0 SLC25A13 Calcium-binding mitochondrial carrier protein Aralar2 0 32610400.0 9939100.0 13782000.0 8889300.0 False True 13030256.35038132 11725779.321815226 7969520.508186675 1.0 0.8998886135860312 0.6116165556446211 23.635362131217036 -6.952368374530486 0.5322075746389762 1.0044756350442032 0.49389357289432806 0.9993742798170053 0.004118432550351293 0.08254842359531629 0.032132580709014355 0.004579908657152912 0.0238455438170631 1.1159163107292014e-07 6.952368374530486 -0.5105820621498751 FGLYLPLFKPSVSTSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGLYLPLFKPSVSTSK 16 1 Q9UJS0;Q9UJS0-2 Q9UJS0 SLC25A13 Calcium-binding mitochondrial carrier protein Aralar2 0 29960200.0 13016000.0 7753500.0 9190700.0 False True 12602814.2045982 10849512.98396836 6783379.954910074 1.0 0.8608801818255689 0.5382432720808599 23.58724258727652 -6.9570500685901 0.4751860335666966 1.0081061146534307 0.37767464936002354 0.9996446638494478 0.0036458511194403733 0.08077220676776932 0.025156230901832954 0.004505615592639151 0.026620436292012616 1.1039513411182869e-07 6.9570500685901 -0.6304314652934071 FGLYLPLFKPSVSTSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGLYLPLFKPSVSTSK 16 1 Q9UJS0;Q9UJS0-2 Q9UJS0 SLC25A13 Calcium-binding mitochondrial carrier protein Aralar2 0 15267200.0 4370600.0 3403500.0 7493100.0 False True 6630519.7336598355 2796118.8333331277 6012085.500657606 1.0 0.4217043226850875 0.9067291467571165 22.660690529825782 -10.166160380509318 7.6934432564566135 1.0000001291104068 0.6642167347211082 0.3898872315577092 0.19801055525994174 4.385319567099914e-07 4.753173255930302e-08 0.19172297000200322 0.06390763190791982 6.820867599634942e-11 10.166160380509318 -0.3357833943892986 FGLYLPLFKPSVSTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGLYLPLFKPSVSTSK 16 1 Q9UJS0;Q9UJS0-2 Q9UJS0 SLC25A13 Calcium-binding mitochondrial carrier protein Aralar2 0 57240100.0 9939100.0 14280000.0 33021000.0 False True 13613853.864078153 13649062.382354856 25222119.888842326 1.0 1.00258622713511 1.8526803754955845 23.698572192739928 -6.907566257246138 0.91214703721556 0.9716105240872136 1.9570088051684988 0.989970229472232 0.0401946163770705 0.10604976822128352 0.14765960452560167 0.032516836882318996 0.08831756704976183 1.2371824273392154e-07 6.907566257246138 0.9853982810812852 FGLYLPLFKPSVSTSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGLYLPLFKPSVSTSK 16 1 Q9UJS0;Q9UJS0-2 Q9UJS0 SLC25A13 Calcium-binding mitochondrial carrier protein Aralar2 0 29478300.0 13016000.0 7602500.0 8859800.0 False True 10823380.706568498 7561543.823521909 10712343.216913227 1.0 0.6986304952696486 0.9897409605496105 23.367647862710797 -10.697139865725951 9.235831167249838 1.000248566253997 0.8441857279990392 0.27639911974335873 0.11884534978668418 0.0006092318446802494 1.9977839603480323e-05 0.11525187876699242 0.03835717170816858 2.0084458829506853e-11 10.697139865725951 -0.15606283825495781 FGLYLPLFKPSVSTSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGLYLPLFKPSVSTSK 16 1 Q9UJS0;Q9UJS0-2 Q9UJS0 SLC25A13 Calcium-binding mitochondrial carrier protein Aralar2 0 13721900.0 4370600.0 4533200.0 4818100.0 False True 5657827.857406001 4280923.434996942 3941255.237880789 1.0 0.7566372719158088 0.696602183242771 22.43181685191823 -13.999999999999998 0.19657034495186806 2.3355546489224204 0.6562681416891821 0.9994871143663738 0.0029708838489722 12.465146129821923 0.14059424838769582 6.391843526690094 0.039228328410083876 1.0000000000000041e-14 13.999999999999998 -1.6792865072332384 FGMAAALAGTMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGMAAALAGTMR 12 0 P49748-2;P49748;P49748-3;J3KSR4 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 7717700.0 2373000.0 2742600.0 2602100.0 False True 3111025.9801646923 2333414.77057107 2332859.6531057092 1.0 0.7500467001717366 0.7498682646752477 21.56895901218691 FGMAAALAGTMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGMAAALAGTMR 12 0 P49748-2;P49748;P49748-3;J3KSR4 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 9295100.0 2373000.0 2503700.0 4418400.0 False True 3250362.2279137424 2393078.2553712786 3374864.9198043984 1.0 0.7362497123612236 1.0383042513912575 21.6321690737098 -6.675954208823978 1.9162510875781376 0.8325197361192408 1.0371212780703312 0.305705641307235 0.11188387674783973 0.4475783033633722 3.173940565095737 0.046911265142020174 0.12437079443442166 2.1088504913567963e-07 6.675954208823978 0.20460154195109037 FGMTPSK(ub)GVLFYGPPGCGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGMTPSKGVLFYGPPGCGK 19 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 1497300.0 1497300.0 0.0 0.0 True False 1962974.7998738247 0.0 0.0 1.0 0.0 0.0 20.904610221328245 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 FGMTPSK(ub)GVLFYGPPGCGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGMTPSKGVLFYGPPGCGK 19 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 8482100.0 1497300.0 0.0 6984800.0 True False 2050892.2730110572 0.0 5335134.096471515 1.0 0.0 2.6013721767251257 20.967820282851136 -6.802494118268035 1.4456984812063336 0.4499928348999153 2.6395353725468884 0.8393597408567064 0.4294259300202359 0.21721589552791243 0.8960101438602266 0.23364973372102169 0.542581127631929 1.5758173641907676e-07 6.802494118268035 2.189542537646973 FGNDVQHFK(ub)VLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGNDVQHFKVLR 12 1 P62993 P62993 GRB2 Growth factor receptor-bound protein 2 1 65040200.0 36317000.0 27248000.0 1475200.0 True False 47611938.69432833 23182704.61187212 1322560.4551176138 1.0 0.4869094863098635 0.027777916450924964 25.50482003891021 -7.993169777214632 0.5324066319096429 1.0216375557454915 1.4691743043475002e-18 0.9924080506680186 0.03460105554036667 0.10660780164459092 0.1398674361269501 0.04354761998402805 0.07700566856522166 1.0158514919860184e-08 7.993169777214632 -1.0216375557454915 FGNDVQHFK(ub)VLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGNDVQHFKVLR 12 1 P62993 P62993 GRB2 Growth factor receptor-bound protein 2 1 103270500.0 73211000.0 28171000.0 1888500.0 True False 70886956.87867533 39419827.20982428 1393845.1962144012 1.0 0.5560942230499785 0.019662928944742256 26.079016861809997 -7.765881877974268 0.5947410066213865 1.0064535405541006 4.612198396157554e-17 0.9902682171116483 0.039540286960668886 0.11609107592503697 0.1378618554607614 0.03941652020515272 0.07738807011984833 1.7144235433293497e-08 7.765881877974268 -1.0064535405541006 down FGNDVQHFK(ub)VLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGNDVQHFKVLR 12 1 P62993 P62993 GRB2 Growth factor receptor-bound protein 2 1 91930600.0 74268000.0 14701900.0 2960700.0 True False 112669985.71808174 12078231.078531003 2375516.3472790923 1.0 0.10720007641389662 0.021083843511110516 26.74752800466468 -13.88501525341619 0.3316966074399624 9.999999986794801 0.006029506219185848 0.9997143560977729 0.007479812519139026 17.550718997484317 0.18394647066025466 109.9135005116488 0.02743835977239665 1.3031210090562017e-14 13.88501525341619 -9.993970480575616 FGNDVQHFK(ub)VLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGNDVQHFKVLR 12 1 P62993 P62993 GRB2 Growth factor receptor-bound protein 2 1 120634100.0 73211000.0 46064000.0 1359100.0 True False 60878190.297217704 45815844.089011915 1643281.5262316042 1.0 0.7525822279757521 0.02699294309191557 25.859422137244273 -7.306703226350241 0.7559328943931733 0.9917870851976796 7.121554179177332e-18 0.9911943136057654 0.03874672800032825 0.10258383789990766 0.11531378314443015 0.03373532395779712 0.06741659639063353 4.935109277612464e-08 7.306703226350241 -0.9917870851976796 down FGNDVQHFK(ub)VLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGNDVQHFKVLR 12 1 P62993 P62993 GRB2 Growth factor receptor-bound protein 2 1 97123200.0 74268000.0 20917000.0 1938200.0 True False 96141390.04114501 19752950.562479235 1585467.4876114123 1.0 0.20545730152253563 0.016490998173969505 26.51865432675713 -9.817064353617514 0.3903529825313985 1.3450528094007816 7.617134117489656e-21 0.9984143954308398 0.016968426277817552 1.2344837858186948 0.18345759994868394 0.5717773241346693 0.04967672672307977 1.5238269368785216e-10 9.817064353617514 -1.3450528094007816 FGNEEQQLAWAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGNEEQQLAWAKR 13 1 M0QY01 M0QY01 EPS15L1 1 14585500.0 3698900.0 4737400.0 6149200.0 True False 3581480.4441754976 6629068.525214639 4538540.047954245 1.0 1.850929700313004 1.2672245789685093 21.772124633901754 -9.975515091433886 6.023913450051272 0.9999996232631279 1.5590771396408374 0.5501966168267151 0.2382966179241788 1.2059597412771904e-06 2.0432829105951087e-07 0.23072985944115412 0.07690990272311599 1.0579981506509949e-10 9.975515091433886 0.5590775163777095 FGNEEQQLAWAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGNEEQQLAWAKR 13 1 M0QY01 M0QY01 EPS15L1 1 14612500.0 3698900.0 7127700.0 3785900.0 True False 3075799.2390539497 7089301.665362314 4577514.185976193 1.0 2.3048648869367794 1.4882356845189086 21.55252990933603 -10.125818266080097 4.834863646099744 0.9999476451464566 1.8965502857318062 0.6164295082682404 0.33338747584962924 0.00019124337887583412 3.4577173526422036e-05 0.32282007350140846 0.1076003451471771 7.484826433994576e-11 10.125818266080097 0.8966026405853496 FGNEEQQLAWAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGNEEQQLAWAKR 13 1 M0QY01 M0QY01 EPS15L1 1 29207900.0 10103000.0 13260000.0 5844900.0 True False 13078532.659903169 12522069.343523217 4781188.173738492 1.0 0.957452159898183 0.36557527499984016 23.640697351604853 -6.921373323519046 0.8144823047218546 1.0124244093302182 0.2670502216981696 0.9945538083180526 0.021369299957874885 0.09737061544934002 0.10147848386830635 0.01854695164177888 0.056307234233916884 1.1984686455940069e-07 6.921373323519046 -0.7453741876320485 down FGNEVIPVTVTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGNEVIPVTVTVK 13 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 116208000.0 32879000.0 45337000.0 37992000.0 False True 43104687.40068889 38572896.32224184 34060952.284997545 1.0 0.8948654693555528 0.7901913768304742 25.36134142730835 -6.971179701285594 0.22826380901331322 1.0435058817739433 0.6385663462360273 0.9999901732623327 0.00026844314459081723 0.07592178026496671 0.007646547636564664 0.002724310569143564 0.010431581256444026 1.0686126198706671e-07 6.971179701285594 -0.40493953553791606 FGNEVIPVTVTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGNEVIPVTVTVK 13 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 102428000.0 37693000.0 24059000.0 40676000.0 False True 36496456.347105026 33665884.16602751 30021735.346156675 1.0 0.9224425474583906 0.8225931597476329 25.121253055364548 -6.967672327146188 0.30876821334852 1.0156081070120935 0.7262593407662491 0.9999581041616643 0.0004699885340878765 0.07706546518085387 0.011719974401208273 0.0015886895765080337 0.008875363223246717 1.0772777073238782e-07 6.967672327146188 -0.2893487662458444 FGNEVIPVTVTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGNEVIPVTVTVK 13 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 174045000.0 25943000.0 104300000.0 43802000.0 False True 39357427.68735112 85686850.10038044 35144515.50090136 1.0 2.177145589418662 0.8929576338190482 25.230132596677997 -6.665637231515811 1.9528147807191323 1.7541805472521932 0.8982443695109722 0.25980358271619897 0.5005371602035631 0.4712652524248169 3.4604094699985115 0.20665855661815669 0.5553049924219154 2.1595475374785797e-07 6.665637231515811 -0.855936177741221 FGNEVIPVTVTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGNEVIPVTVTVK 13 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 137551000.0 32879000.0 39704000.0 64968000.0 False True 45035254.82156584 37949745.99642976 49623896.45796032 1.0 0.8426675089724801 1.1018899893999743 25.42455148883124 -6.74240265151772 1.6778016860516383 0.9066491217306022 1.1021257461018024 0.615705017284666 0.06610213862986206 0.3134946795992016 1.7336547693246624 0.031155689984357842 0.07625545033101352 1.8096615061469165e-07 6.74240265151772 0.19547662437120017 FGNEVIPVTVTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGNEVIPVTVTVK 13 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 80484000.0 37693000.0 20288000.0 22503000.0 False True 31343399.583027475 20178704.517147277 27208273.25788377 1.0 0.643794380494517 0.8680702674197828 24.901658330798824 -10.442272476356258 5.928556113451956 1.0001205011928314 0.7559323239571498 0.6122593549153124 0.09156024742950672 0.0001459023801682935 1.3725706637415977e-05 0.08869635760418217 0.029550942789092444 3.611831852093427e-11 10.442272476356258 -0.24418817723568154 FGNEVIPVTVTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGNEVIPVTVTVK 13 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 108735000.0 25943000.0 50184000.0 32608000.0 False True 33583724.91298303 47391216.28471859 26673678.586334188 1.0 1.4111363884593326 0.7942441958254157 25.001258918770446 -6.727066712195655 1.7340329805389154 1.2482236151462562 0.7948096191823556 0.5455978023404886 0.17287497728154488 0.3417490407645197 2.0117867642388676 0.07905123600889437 0.19680701533085437 1.8747065113301978e-07 6.727066712195655 -0.45341399596390064 FGNICVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGNICVVR 8 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 21597500.0 3405900.0 4730600.0 13461000.0 False True 4465167.882782523 4024812.9197343756 12068184.847029695 1.0 0.9013799761603287 2.7027393289206545 22.090282988591056 -6.893953460231329 0.9986861113045085 0.912183275470397 2.8702364351838607 0.9833109674219603 0.10682454413131277 0.11599463670535569 0.2035718758890841 0.08104786490699864 0.20515536533835937 1.2765756015924067e-07 6.893953460231329 1.9580531597134638 up FGNICVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGNICVVR 8 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 31746100.0 3405900.0 3064200.0 25276000.0 False True 4665153.270986691 2928813.5120456438 19306329.37556036 1.0 0.6278064925026982 4.138412663873105 22.153493050113948 -6.880691120995024 1.075982284007178 0.767171310249342 4.390483114236748 0.9742367234912697 0.2527281288504449 0.12701757522127577 0.2686262108852931 0.18082625727445178 0.43804545522441385 1.3161605793721342e-07 6.880691120995024 3.6233118039874057 up FGNQADHFLGSLAFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGNQADHFLGSLAFAK 16 0 Q9H488;Q9H488-2 Q9H488 POFUT1 GDP-fucose protein O-fucosyltransferase 1 0 8364800.0 1915700.0 3153000.0 3296100.0 False True 2511501.2516651875 2682584.690297737 2955051.1904237852 1.0 1.0681199893964284 1.1766074926160253 21.260118563334796 -6.964243059443494 0.37082077592548224 0.9917344735721795 1.2567741259941767 0.9998966659329978 0.000739249593649007 0.07821884330674331 0.01577189108931857 0.0014281869243787195 0.009209723867707402 1.0858177592807677e-07 6.964243059443494 0.26503965242199723 FGNQADHFLGSLAFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGNQADHFLGSLAFAK 16 0 Q9H488;Q9H488-2 Q9H488 POFUT1 GDP-fucose protein O-fucosyltransferase 1 0 5445130.0 3512100.0 813330.0 1119700.0 False True 2920466.762410816 808948.4298566355 1353824.0930921421 1.0 0.2769928561655181 0.4635642872287216 21.47776753500477 -10.874955851364422 11.07335575863975 1.025971085603305 0.37027857170336864 0.9382318252641749 0.07616746778094931 0.035351124435008076 0.00039919635327519544 0.05338476583162298 0.024582944519867225 1.333656999495405e-11 10.874955851364422 -0.6556925138999364 FGNSSVGFGSNSHSQAPEK(ub)VTLLVDGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGNSSVGFGSNSHSQAPEKVTLLVDGTR 28 1 Q7Z5Y7 Q7Z5Y7 KCTD20 BTB/POZ domain-containing protein KCTD20 1 27872700.0 4085700.0 10428000.0 13359000.0 True False 5356392.265975082 8872183.048025632 11976738.828576596 1.0 1.656372910621872 2.2359711973776326 22.352830187091396 -6.972590319535995 0.1861896904397852 0.5870743619841241 3.3210414335025487 0.999996171284101 0.0009879409522839911 0.07547081875312048 0.005913440899790676 0.02114313714762808 0.0638651606486839 1.0651473236287281e-07 6.972590319535995 2.7339670715184248 FGNSSVGFGSNSHSQAPEK(ub)VTLLVDGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGNSSVGFGSNSHSQAPEKVTLLVDGTR 28 1 Q7Z5Y7 Q7Z5Y7 KCTD20 BTB/POZ domain-containing protein KCTD20 1 76172000.0 16445000.0 21539000.0 38188000.0 True False 15922962.476537872 30139635.024401177 28185417.184556756 1.0 1.8928409250986589 1.7701113863759546 23.924605439326754 -10.286349054590946 5.432795771103233 0.9998896607668938 1.8314761557373433 0.9839224181235076 0.05010412437309123 6.697084996084318e-05 8.797153134423222e-06 0.048519453402190896 0.016171036606088665 5.1719098403633145e-11 10.286349054590946 0.8315864949704496 FGNSSVGFGSNSHSQAPEK(ub)VTLLVDGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGNSSVGFGSNSHSQAPEKVTLLVDGTR 28 1 Q7Z5Y7 Q7Z5Y7 KCTD20 BTB/POZ domain-containing protein KCTD20 1 207591000.0 38309000.0 123700000.0 45582000.0 True False 58117553.76304733 101624768.52748875 36572697.720699646 1.0 1.748607123793026 0.6292883191507198 25.792470643710285 -6.7264048350900225 1.7358452304728818 1.4522766960251126 0.6303137386046165 0.5428045951661238 0.31479404952247303 0.3429867217479886 2.0228579002874385 0.14379750191664264 0.35835253748646284 1.8775657954758167e-07 6.7264048350900225 -0.8219629574204961 FGNSSVGFGSNSHSQAPEK(ub)VTLLVDGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGNSSVGFGSNSHSQAPEKVTLLVDGTR 28 1 Q7Z5Y7 Q7Z5Y7 KCTD20 BTB/POZ domain-containing protein KCTD20 1 33839700.0 4085700.0 10720000.0 19034000.0 True False 5596293.701890925 10246354.953700554 14538561.217535036 1.0 1.8309180145849788 2.5978910314558044 22.416040248614287 -6.972085405110421 0.2022654122936391 0.5566132044363428 3.89342417126131 0.9999944053850606 0.0015433679700640904 0.07563163816755983 0.006549179700816317 0.02444300431209701 0.08096295963538716 1.0663863930226029e-07 6.972085405110421 3.3368109668249675 FGNSSVGFGSNSHSQAPEK(ub)VTLLVDGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGNSSVGFGSNSHSQAPEKVTLLVDGTR 28 1 Q7Z5Y7 Q7Z5Y7 KCTD20 BTB/POZ domain-containing protein KCTD20 1 62525000.0 16445000.0 29790000.0 16290000.0 True False 13674746.137025088 29629515.357147984 19696163.683550034 1.0 2.1667323883201406 1.4403312124545877 23.70501071476103 -10.106359780861219 4.73487682385254 0.9999631145104362 1.8035318003984713 0.6199911595639975 0.2965520383324476 0.00014769275187679682 2.787439640095654e-05 0.28715205664704657 0.0957117587982102 7.8278089799917e-11 10.106359780861219 0.8035686858880351 FGNSSVGFGSNSHSQAPEK(ub)VTLLVDGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGNSSVGFGSNSHSQAPEKVTLLVDGTR 28 1 Q7Z5Y7 Q7Z5Y7 KCTD20 BTB/POZ domain-containing protein KCTD20 1 201025600.0 38309000.0 125293600.0 37423000.0 True False 49591755.68328525 118320901.01807389 30612397.992406297 1.0 2.385898611328124 0.6172880465840033 25.563596965802734 -6.69769438330192 1.838891748452037 1.862546464880642 0.6227507831833075 0.40660853135113284 0.5852603993670105 0.4004071163231423 2.630654916436902 0.25405140881665145 0.6552676726049322 2.0058830877042718e-07 6.69769438330192 -1.2397956816973346 FGPALSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGPALSVK 8 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAP2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 20268600.0 3287000.0 7049800.0 9931800.0 False True 4309288.831353276 5997997.31990517 8904152.608552814 1.0 1.3918763755785608 2.0662696229058706 22.03901836807327 -6.962873746495459 0.39283953477349154 0.9598693424801499 2.522618898097815 0.9998623845848539 0.005165918973660085 0.07869008579791453 0.017451775057224044 0.00869484271128496 0.05666158411107049 1.089246701606613e-07 6.962873746495459 1.562749555617665 up FGPALSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGPALSVK 8 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAP2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 18048900.0 2742700.0 1366200.0 13940000.0 False True 2655634.4897780754 1911730.784638879 10288695.808964109 1.0 0.7198772240673216 3.874289119442755 21.34062516327109 -6.885241187731335 1.0501031173290494 0.8106749551023357 4.121612444900392 0.9776742677311738 0.21300621067765502 0.12309013044350164 0.24507250242872455 0.15543863084816803 0.38144082366401605 1.3024432588317754e-07 6.885241187731335 3.3109374897980564 up FGPALSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGPALSVK 8 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAP2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 28130500.0 3287000.0 4093500.0 20750000.0 False True 4502292.727834999 3912635.63460571 15849277.359664388 1.0 0.8690318180371104 3.52026807623541 22.10222842959616 -6.895282776074632 0.9906220966527579 0.8750565230724355 3.7733583853489123 0.9840692649307565 0.15399830868648226 0.11496087687606062 0.19765399134724887 0.11755095271105322 0.2992108560174654 1.2726741527110583e-07 6.895282776074632 2.898301862276477 up FGPALSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGPALSVK 8 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAP2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 7548400.0 2742700.0 1935700.0 2870000.0 False True 2280676.5722115375 1925271.999893635 3470103.7306193155 1.0 0.8441670438288967 1.5215238201243102 21.121030438705365 -6.846168832519407 1.2533994966156885 0.9170389221597682 1.5466710963848627 0.9345501511322248 0.07410209289164749 0.16171972406797291 0.49083049834812353 0.046303836400493 0.10692233563499615 1.4250534945893205e-07 6.846168832519407 0.6296321742250944 FGPIPLGSLGWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGPIPLGSLGWK 12 0 A0A3B3ISG8;Q16795 A0A3B3ISG8 NDUFA9 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial 0 8400600.0 4295100.0 1796800.0 2308700.0 False True 5630917.693807567 1528724.4438715444 2069817.8706141762 1.0 0.271487620135651 0.3675809136564714 22.42493863273348 -10.765587728870033 7.103427065052618 1.0147121379602042 0.3195342668960612 0.9852637354830328 0.03922992280491714 0.008826545418904349 0.0002912746014881876 0.036680125280344714 0.012661403141370558 1.715585121451724e-11 10.765587728870033 -0.695177871064143 FGPIPLGSLGWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGPIPLGSLGWK 12 0 A0A3B3ISG8;Q16795 A0A3B3ISG8 NDUFA9 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial 0 9266700.0 4295100.0 1994100.0 2977500.0 False True 5883114.540713148 1905994.0683931229 2274275.8235373837 1.0 0.3239770456962885 0.3865768391552848 22.48814869425637 -10.066150645918457 5.650144236482004 1.0000034118460919 0.3552769424456931 0.9929789715494683 0.02555625866358367 1.098368948580505e-06 1.815211151584629e-07 0.024744871896320585 0.008248247016204597 8.587156028237376e-11 10.066150645918457 -0.6447264694003988 FGPIPLGSLGWKTVK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGPIPLGSLGWKTVK 15 1 A0A3B3ISG8;Q16795 A0A3B3ISG8 NDUFA9 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial 1 2103270.0 488270.0 882660.0 732340.0 True False 640126.6984134058 750970.568581732 656564.481901323 1.0 1.173159267443554 1.025678953133277 19.287997956240464 -10.693922579003589 3.04639840984365 0.9883979737027101 1.0994191103294155 0.3773012997695726 0.060208586875810585 44725680.95217981 38750515.59789465 3944891.5999301956 0.02203408312141667 2.023379851282923e-11 10.693922579003589 0.11102113662670543 FGPYYTEPVIAGLDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGPYYTEPVIAGLDPK 16 0 P49720;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 8224900.0 3233800.0 1527300.0 3463800.0 False True 3131144.789092628 2137158.8547642846 2556526.8682273985 1.0 0.6825487157952891 0.8164831205292977 21.578258791846178 -10.111644930888584 5.106104600914133 1.000007290313824 0.7495159184952821 0.8234316481828995 0.0546784917686424 15484710.218546752 30664450.461050007 870.0102229460911 0.018717902593111953 7.733125691616229e-11 10.111644930888584 -0.25049137181854186 FGQAATMEGIGAIGGTPPAFNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGQAATMEGIGAIGGTPPAFNR 22 0 Q15233;Q15233-2 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 16829500.0 3300800.0 7694400.0 5834300.0 False True 4327380.76499267 6546425.512536288 5230622.602557404 1.0 1.5127916557505372 1.2087271461923836 22.045062637992082 -10.316172696014933 5.133196386760986 0.999888571108249 1.360759400971515 0.6524043866667523 0.1241338162180392 0.00015834740001590447 2.109456402045963e-05 0.12022896370145872 0.040064016909442515 4.828667532124601e-11 10.316172696014933 0.3608708298632659 FGQAATMEGIGAIGGTPPAFNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGQAATMEGIGAIGGTPPAFNR 22 0 Q15233;Q15233-2 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 27170100.0 7954400.0 3521700.0 15694000.0 False True 7701891.926018419 4927933.175422886 11583270.590092028 1.0 0.639834111249395 1.5039513279797645 22.87678144851059 -6.79349682574824 1.4822088363097956 0.799606774424185 1.5140606484521217 0.8124542362647057 0.1534777988886314 0.23020040458666088 0.9989629903217468 0.08148479441561231 0.19031180269923267 1.608804136570781e-07 6.79349682574824 0.7144538740279367 FGQAATMEGIGAIGGTPPAFNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGQAATMEGIGAIGGTPPAFNR 22 0 Q15233;Q15233-2 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 17750900.0 3300800.0 6304800.0 8145300.0 False True 4521194.96076598 6026233.088814484 6221547.897719258 1.0 1.3328850317468992 1.3760848518386397 22.108272699514973 -12.302895164899656 0.3179233392164256 5.36085441112568e-12 1.3854601827475275 0.9995649090610372 0.00350498613411034 6.304635111660987 0.17361760191174533 4.132761043927633 0.01449605950101687 4.978572491023103e-13 12.302895164899656 1.3854601827421666 FGQFCTVGILINSGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGQFCTVGILINSGSR 16 0 Q10713 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 20780500.0 6280500.0 9054900.0 5445100.0 False True 8233796.320448509 7703944.215723751 4881693.285087381 1.0 0.9356491120130238 0.5928848729186765 22.973126330454416 -6.938405059110987 0.6742428068863063 1.0039742717236402 0.504635048338093 0.997947369729389 0.008095721043070943 0.08850202394857573 0.057981096170355684 0.007788381014989989 0.02971436200764444 1.1523779530318701e-07 6.938405059110987 -0.49933922338554715 FGQFCTVGILINSGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGQFCTVGILINSGSR 16 0 Q10713 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 158647000.0 41310000.0 52699000.0 64638000.0 False True 62670290.165535 43294451.71083368 51862270.96815819 1.0 0.6908289653115903 0.8275415804070971 25.901278337079365 -10.01547362377052 4.526212218313687 1.0000079968764561 0.7591852728496773 0.8053346155163753 0.055812691472287394 38542263.23793313 3687.1328692680777 3383.642603861093 0.019106168810602443 9.649979177392912e-11 10.01547362377052 -0.24082272402677884 FGQFCTVGILINSGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGQFCTVGILINSGSR 16 0 Q10713 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 39764500.0 6280500.0 10462000.0 23022000.0 False True 8602570.574130729 9999754.246792467 17584677.7529732 1.0 1.1624146713615215 2.044118976001553 23.036336391977308 -6.937988653613087 0.678023539843997 0.9896743472028271 2.2684432898642055 0.9978883282416371 0.021080356934938954 0.08869641577505515 0.05888021872739449 0.020219908641322174 0.07658338218843672 1.1534833933592089e-07 6.937988653613087 1.2787689426613784 up FGQFCTVGILINSGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGQFCTVGILINSGSR 16 0 Q10713 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 44946100.0 19506000.0 7423100.0 18017000.0 False True 16220103.262317514 7383110.286930015 21784271.398804218 1.0 0.4551826932003837 1.343041474305121 23.95127966844978 -6.740673699625262 1.684271054440062 0.6760858518066625 1.3436336561316609 0.6079292011441836 0.22890595117170068 0.3166071132902526 1.7637711789657693 0.10750627133203246 0.2636116738783173 1.81688023466636e-07 6.740673699625262 0.6675478043249984 FGQFCTVGILINSGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGQFCTVGILINSGSR 16 0 Q10713 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 145792000.0 41310000.0 57191000.0 47291000.0 False True 53476609.341838986 54008270.575070605 38684523.246636786 1.0 1.0099419398457572 0.7233914738190182 25.672404659171814 -6.8988632646414825 0.9684421114444975 1.0122881539162363 0.6939996572744931 0.9859917669724295 0.015717712967068944 0.11224630186461665 0.18218340804689567 0.012198267370874654 0.03156007957018182 1.2622248769734806e-07 6.8988632646414825 -0.3182884966417432 FGQGFGK(ub)TNIYTQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGQGFGKTNIYTQK 14 1 Q9H5V9-2;Q9H5V9-3;Q9H5V9 Q9H5V9-2 CXorf56 UPF0428 protein CXorf56 1 10856600.0 2326900.0 3722200.0 4807500.0 True False 2253033.8331806622 5208493.871016577 3548271.5280914614 1.0 2.3117690441708194 1.5748860384765198 21.103437547609218 -10.068798006256289 4.963417112560519 0.9999814281408217 1.9433275413254878 0.6860358168649132 0.30083122737600343 7.499479557709518e-05 1.4070115081422755e-05 0.2912855168894677 0.0970928611329268 8.534969898082777e-11 10.068798006256289 0.9433461131846661 FGQGFGK(ub)TNIYTQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGQGFGKTNIYTQK 14 1 Q9H5V9-2;Q9H5V9-3;Q9H5V9 Q9H5V9-2 CXorf56 UPF0428 protein CXorf56 1 7313500.0 2326900.0 2810400.0 2176200.0 True False 1934920.4491482938 2795259.817379279 2631233.358388067 1.0 1.4446381083055306 1.3598664273491314 20.883842823043494 -10.078634614695689 4.85078549628902 0.999986349394184 1.402252267831264 0.967764418151149 0.034607893843763206 5.109283584941025e-06 9.704469936620843e-07 0.03351008531063309 0.011169649706752792 8.34382881378182e-11 10.078634614695689 0.40226591843708015 FGQGGAGPVGGQGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGQGGAGPVGGQGPR 15 0 P23246 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 20387100.0 4502000.0 2720100.0 13165000.0 False True 4359086.47427021 3806250.1151341056 9716691.558465755 1.0 0.87317609723981 2.229066024686401 22.055594393058147 -6.88399670236498 1.05721045812843 0.9163216042969734 2.332855553747574 0.9767707637999444 0.09319590196140189 0.12415076319788496 0.2513670597108581 0.06764058404665668 0.16537329195529943 1.3061808060363852e-07 6.88399670236498 1.4165339494506006 up FGQHLIKPSVVFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGQHLIKPSVVFLK 14 1 E9PBZ0;P49789 E9PBZ0 FHIT Bis(5-adenosyl)-triphosphatase 0 5916400.0 1755400.0 1069200.0 3091800.0 False True 1699675.78785738 1496137.1358043405 2281964.827988183 1.0 0.8802485429826464 1.3425883008340311 20.69682814871185 -6.837940467728224 1.291958344920759 0.9362687728813708 1.3571824474051024 0.9208500630886003 0.05511961645585113 0.17121759196493536 0.5560414131746482 0.0334651604455365 0.07705857545064722 1.4523106839640638e-07 6.837940467728224 0.42091367452373163 FGQSSVLAIHAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGQSSVLAIHAR 12 0 H3BS42;Q9H5H4 H3BS42 ZNF768 Zinc finger protein 768 0 2812100.0 1390800.0 1421300.0 0.0 False True 1823352.2685263574 1209247.580184008 0.0 1.0 0.6632001950787755 0.0 20.798161883833224 -7.505289580641076 0.713252692968026 0.9932545733377254 5.1727206720036523e-17 0.9870822371071626 0.04721670523881003 0.11918874697128556 0.1425812539267884 0.04174415972357122 0.07564356334565431 3.1239956419832145e-08 7.505289580641076 -0.9932545733377254 down FGQVYTEAK(ub)RPPGFDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGQVYTEAKRPPGFDR 16 2 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 46924900.0 3383100.0 6457700.0 37084100.0 True False 4435276.861987003 5494236.331917445 33246993.06780579 1.0 1.238758369067411 7.496035558175086 22.080592733590926 -6.914958299619835 0.8612720039198799 0.8353002840010622 8.39673219142984 0.9926623056244298 0.2576290121370437 0.1012301535080433 0.12165267845917323 0.2162383049209661 0.6195708756971574 1.2163027828197162e-07 6.914958299619835 7.561431907428777 up FGQVYTEAK(ub)RPPGFDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGQVYTEAKRPPGFDR 16 2 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 78801700.0 3179700.0 6647500.0 68974500.0 True False 3078762.16397978 9301881.416254554 50908009.259354085 1.0 3.0213056159656135 16.53521985392582 21.553918992049592 -6.933590303151999 0.7167082628706848 0.819335494250238 19.58150919594499 0.9971980407661896 0.3650557899069076 0.09081594461555721 0.06885826928448348 0.3399948769932292 1.1995522753071433 1.165224739660067e-07 6.933590303151999 18.76217370169475 FGQVYTEAK(ub)RPPGFDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGQVYTEAKRPPGFDR 16 2 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 146724100.0 6238100.0 49528000.0 90958000.0 True False 9463653.766197627 40689341.4359698 72980111.43169239 1.0 4.299538258817582 7.7116210329210775 23.173965862050164 -7.141932181448675 0.2637360201617662 9.009025978013949e-13 11.531512453493491 0.9999709637496784 0.014765303757132725 0.08565053185775597 0.012136994230791034 0.09986866441018447 0.38008091484886936 7.212200946667145e-08 7.141932181448675 11.53151245349259 FGQVYTEAK(ub)RPPGFDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGQVYTEAKRPPGFDR 16 2 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 61499300.0 3383100.0 5082300.0 53033900.0 True False 4633923.494839853 4857747.181081381 40508385.08745571 1.0 1.0483011181541448 8.741703468467744 22.143802795113817 -6.908276808242074 0.907385144641481 0.7486214199340863 9.700167648447717 0.9902549817185843 0.35914602733762385 0.10556869497816306 0.1450282596224764 0.2915550623563475 0.795536016627447 1.2351599230239707e-07 6.908276808242074 8.951546228513632 up FGQVYTEAK(ub)RPPGFDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGQVYTEAKRPPGFDR 16 2 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 47794500.0 3179700.0 8965600.0 35649200.0 True False 2644061.434594021 8917300.533267736 43103282.896722674 1.0 3.3725769063444364 16.301921858839453 21.33432426748387 -6.937904542474928 0.6787771912960482 0.8482682643055476 19.58364160533525 0.9978763659718731 0.309875270460799 0.08873572810559714 0.05906116412878085 0.2970506977394514 1.1234633150080602 1.1537068136439936e-07 6.937904542474928 18.7353733410297 FGQVYTEAK(ub)RPPGFDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGQVYTEAKRPPGFDR 16 2 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 107829100.0 6238100.0 38288000.0 63303000.0 True False 8075343.421334444 36157239.14214305 51782503.543630905 1.0 4.477486251125663 6.412421223699969 22.945092184142613 -8.544026972423422 0.31713001603260077 9.643409502231207e-23 7.302544659621712 0.9984681670870921 0.08764412769660732 0.1960438076825932 0.09221399897795811 0.7807499942530346 0.5937752224226143 2.857413074510138e-09 8.544026972423422 7.302544659621712 FGQYNK(ub)EDPTSFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGQYNKEDPTSFR 13 1 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 28214800.0 5656800.0 10163000.0 12395000.0 True False 7416119.580529119 8646720.015063712 11112484.301235624 1.0 1.1659358942600537 1.4984230203638087 22.82223307607692 -6.960008650910162 0.43531289656839456 0.9875136949439236 1.689708026849482 0.9997705167209963 0.0031392993606488436 0.07969804302093747 0.021119991089938877 0.004359497096740579 0.027574375575720646 1.0964563551106773e-07 6.960008650910162 0.7021943319055584 FGQYNK(ub)EDPTSFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGQYNKEDPTSFR 13 1 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 39868400.0 5381000.0 5412400.0 29075000.0 True False 5210183.1004104875 7573599.54529313 21459385.26869665 1.0 1.4536148537076248 4.118739179628055 22.312902643058766 -6.936282179268159 0.6932987552516426 0.9673081793443448 4.765073080569422 0.9976350852531333 0.06690521275164224 0.08950471178338734 0.0626473317810376 0.0634199682110506 0.23338572429836452 1.1580246946415623e-07 6.936282179268159 3.7977649012250776 up FGQYNK(ub)EDPTSFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGQYNKEDPTSFR 13 1 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 123395600.0 8570600.0 19928000.0 94897000.0 True False 13002226.794789046 16371692.701825356 76140566.35516733 1.0 1.2591452956647937 5.855963563539938 23.63225538828724 -6.918509107647897 0.8357161483685656 0.8930224544279439 6.57238940587181 0.9937565489648404 0.1762482394266068 0.09905683343434585 0.11022046814874328 0.15066918629710613 0.44508514637317514 1.206398788380733e-07 6.918509107647897 5.679366951443866 up FGQYNK(ub)EDPTSFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGQYNKEDPTSFR 13 1 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 33499300.0 5656800.0 4549500.0 23293000.0 True False 7748271.829271987 4348488.046815369 17791673.134393387 1.0 0.5612203782509713 2.2962117910188313 22.88544313759981 -6.839680085554725 1.283926520042283 0.7665740536447442 2.3529000064298455 0.9238966620742346 0.20319778471932884 0.1691718722387849 0.5418620859456089 0.1241071172207295 0.28588722423798635 1.44650491764218e-07 6.839680085554725 1.5863259527851015 up FGQYNK(ub)EDPTSFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGQYNKEDPTSFR 13 1 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 42331900.0 5381000.0 7726900.0 29224000.0 True False 4474539.91871889 7685273.656030426 35334603.28349086 1.0 1.7175561723965587 7.8968126165712125 22.093307918493043 -6.928751535227576 0.7569670620057035 0.9015507139844015 9.125982206836808 0.9962871840950827 0.18864511107852905 0.09329128291341542 0.08089337143476767 0.17060548535169803 0.5630034162879273 1.1782798879416095e-07 6.928751535227576 8.224431492852407 up FGQYNK(ub)EDPTSFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGQYNKEDPTSFR 13 1 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 98981600.0 8570600.0 16048000.0 74363000.0 True False 11094810.651783252 15154914.692674233 60829697.02881407 1.0 1.3659462219157752 5.482716103770279 23.40338171037969 -6.924345961612387 0.7918172221151925 0.9225867653509149 6.217835712627094 0.9953055952286554 0.13925249863730077 0.09568192974043709 0.0928517918486466 0.12282965623130772 0.3847249529675147 1.1902934353046104e-07 6.924345961612387 5.295248947276179 up FGSALVPTGNLQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGSALVPTGNLQLR 14 0 Q9BXR0;K7EL95 Q9BXR0 QTRT1 Queuine tRNA-ribosyltransferase 0 23615700.0 7273800.0 2528900.0 13813000.0 False True 7042897.200476818 3538702.9580392796 10194960.918882445 1.0 0.5024498948812859 1.4475521406435161 22.7477375943424 -6.763692177590025 1.5988659792460675 0.7123216974899157 1.4516135785980968 0.7057489031096571 0.20939422167348745 0.276757551661372 1.395222812873915 0.10329896746011023 0.2473180199000123 1.7230894461691865e-07 6.763692177590025 0.7392918811081811 FGSALVPTGNLQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGSALVPTGNLQLR 14 0 Q9BXR0;K7EL95 Q9BXR0 QTRT1 Queuine tRNA-ribosyltransferase 0 26014200.0 13307000.0 6006300.0 6700900.0 False True 18226957.508153465 5740921.8058219915 5118285.429367475 1.0 0.3149687381042012 0.28080854564333696 24.11957042722201 -13.541721038730744 0.43159574718213894 9.999373082922043 0.28015025168821917 0.9998714330285132 0.0037562034873602247 21.14285300586179 0.2202948689072666 177.61573318312463 0.008055277429998243 2.8726251687852574e-14 13.541721038730744 -9.719222831233823 FGSALVPTGNLQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGSALVPTGNLQLR 14 0 Q9BXR0;K7EL95 Q9BXR0 QTRT1 Queuine tRNA-ribosyltransferase 0 15702300.0 7273800.0 3004800.0 5423700.0 False True 6048486.983976477 2988612.5459938985 6557770.593644587 1.0 0.49410911421505366 1.084200166259313 22.528142869776676 -6.679758885989625 1.9026291634585728 0.6798454187735273 1.081954481918379 0.32302083580479257 0.21442041687674493 0.439089010724646 3.072906133775716 0.09043346899043045 0.23859593596080395 2.0904563998779007e-07 6.679758885989625 0.40210906314485173 FGSALVPTGNLQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGSALVPTGNLQLR 14 0 Q9BXR0;K7EL95 Q9BXR0 QTRT1 Queuine tRNA-ribosyltransferase 0 10664000.0 2983400.0 3904600.0 3776000.0 False True 3862070.1116059646 3687305.577580748 3088806.7450318313 1.0 0.9547484822970901 0.7997800805711973 21.880942924381277 -6.948443554616621 0.5756801890744621 1.0018839586973076 0.7450363231040656 0.9990733871280582 0.0026097253080844224 0.08411688421544389 0.03859625336720955 0.002747261449032571 0.012930482925267597 1.1260468120247032e-07 6.948443554616621 -0.256847635593242 FGSGMNMGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGSGMNMGR 9 0 P52272-2;P52272;A0A087X0X3;M0R019;M0QYL3;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 11017700.0 2382100.0 3402000.0 5233600.0 False True 3122956.1682892162 2894434.8608921384 4692077.276236131 1.0 0.9268253234811605 1.5024473682595723 21.57448089012821 -6.874996480022875 1.1073835400077017 0.957062739862441 1.5395119465408729 0.9694176620785185 0.0447431461979971 0.13215157559976443 0.29988959072436683 0.03125312324930988 0.07470243430294358 1.3335322404608154e-07 6.874996480022875 0.5824492066784319 FGSGMNMGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGSGMNMGR 9 0 P52272-2;P52272;A0A087X0X3;M0R019;M0QYL3;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 10124900.0 3041900.0 1092400.0 5990600.0 False True 2945336.549551873 1528601.0167907432 4421482.145852255 1.0 0.5189902719345661 1.5011806194185089 21.49000106267647 -6.773570880500226 1.5610417789834412 0.7253581819216711 1.507429701093837 0.7439134973295726 0.2029289024120107 0.26070975697262855 1.254309895158969 0.10244140821587366 0.24303750556438922 1.6843375063388214e-07 6.773570880500226 0.7820715191721658 FGSGMNMGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGSGMNMGR 9 0 P52272-2;P52272;A0A087X0X3;M0R019;M0QYL3;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 11601400.0 2382100.0 4188800.0 5030500.0 False True 3262826.7438319945 4003724.965490754 3842399.5063996017 1.0 1.227072498734217 1.177629033985094 21.637690951651102 -10.099173422845396 4.519756494182755 0.9999828372025515 1.2023507663675552 0.9571406909348289 0.020185209985312497 3.4911916841846346e-06 6.958261300052967e-07 0.01954590241793959 0.006514748505624167 7.958414908501335e-11 10.099173422845396 0.20236792916500368 FGSITNQLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGSITNQLLK 10 0 E7ENN3;A0A0C4DG40;Q8NF91-4;Q8NF91;H0Y325;Q8NF91-8;Q8NF91-2 E7ENN3 SYNE1 Nesprin-1 0 20099900.0 3662200.0 7620800.0 8816900.0 False True 4801179.664795243 6483806.345645733 7904611.765676838 1.0 1.3504610946323021 1.6463894954062186 22.194957493377185 -6.973081907564946 0.16907703816058564 0.7352687837183653 2.2694997755561843 0.9999975224139049 0.00041582036320409035 0.07531480349935417 0.005268717993195162 0.012577627810318123 0.034392338325784616 1.0639423406927177e-07 6.973081907564946 1.534230991837819 FGSITNQLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGSITNQLLK 10 0 E7ENN3;A0A0C4DG40;Q8NF91-4;Q8NF91;H0Y325;Q8NF91-8;Q8NF91-2 E7ENN3 SYNE1 Nesprin-1 0 12540700.0 5201700.0 2344900.0 4994100.0 False True 5036574.880766621 3281230.7984919576 3685995.3902114597 1.0 0.6514805946839252 0.7318456446040988 22.26401153274175 -10.605469803505509 6.595808448239144 1.000770512823378 0.6916631196440136 0.9515199918895058 0.03280889424295392 0.00037261963811539817 2.2288333721854778e-05 0.03184209380252129 0.010589025084203408 2.4804483972696226e-11 10.605469803505509 -0.3091073931793643 FGSITNQLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGSITNQLLK 10 0 E7ENN3;A0A0C4DG40;Q8NF91-4;Q8NF91;H0Y325;Q8NF91-8;Q8NF91-2 E7ENN3 SYNE1 Nesprin-1 0 23182100.0 3662200.0 7498900.0 12021000.0 False True 5016214.307233748 7167573.802453836 9181887.380266305 1.0 1.4288810970690926 1.8304416075336638 22.258167554900076 -6.971918993326907 0.20728840662725126 0.7823484278720447 2.4881503952999084 0.9999937339304857 0.0008487882537388633 0.07568479693640189 0.006754265566426058 0.01228787813512815 0.04187645273847843 1.0667950863689305e-07 6.971918993326907 1.7058019674278637 FGSITNQLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGSITNQLLK 10 0 E7ENN3;A0A0C4DG40;Q8NF91-4;Q8NF91;H0Y325;Q8NF91-8;Q8NF91-2 E7ENN3 SYNE1 Nesprin-1 0 13869200.0 5201700.0 4241700.0 4425800.0 False True 4325444.024382087 4218849.120188475 5351214.317412875 1.0 0.9753563094117625 1.2371479753867174 22.044416808176027 -6.883840285203904 1.0581219935099577 0.9837873508765155 1.2571254498432256 0.9766544851425722 0.01803420169926741 0.124283930776122 0.25217647267821125 0.013080081867172452 0.03196411621926473 1.3066513298372547e-07 6.883840285203904 0.27333809896671013 FGSLLPIHPVTSG ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGSLLPIHPVTSG 13 0 Q15257;Q15257-2;A6PVN5;F6WIT2;Q15257-3;Q15257-4;B7ZBQ0;Q68CR8 Q15257 PPP2R4;DKFZp781M17165 Serine/threonine-protein phosphatase 2A activator 0 10523700.0 2762000.0 4013300.0 3748400.0 False True 3621008.7472460456 3414531.283720874 3360551.52519174 1.0 0.9429779163935443 0.9280705349711194 21.78796023125101 -13.999944868713513 0.18833992948836029 1.3039334861598264 0.9171953337177721 0.9994903713759581 0.0006997430157609088 12.323901831731408 0.1376213167861262 1.3738554545639148 0.01038897110260245 1.0001269525362142e-14 13.999944868713513 -0.38673815244205434 FGSLLPIHPVTSG ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGSLLPIHPVTSG 13 0 Q15257;Q15257-2;A6PVN5;F6WIT2;Q15257-3;Q15257-4;B7ZBQ0;Q68CR8 Q15257 PPP2R4;DKFZp781M17165 Serine/threonine-protein phosphatase 2A activator 0 10388600.0 2762000.0 3385400.0 4241200.0 False True 3783186.040243465 3235821.8339792765 3239515.91025584 1.0 0.8553166034020988 0.8562930492435848 21.8511702927739 -9.293165661987064 9.668719800756687 0.9999999823261716 0.8558048263228297 0.999965602071738 0.0003986323456663147 0.0 0.0 0.00038597410893897755 0.0001286580363129925 5.091366234281307e-10 9.293165661987064 -0.14419515600334187 FGTINIVHPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGTINIVHPK 10 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 7225400.0 1729600.0 1913700.0 3582100.0 False True 2267522.349470226 1628183.419544173 3211458.6539295 1.0 0.7180451473497381 1.4162853365832584 21.112685339840247 -6.797084858311722 1.4677159627685556 0.843854147152615 1.4252525831405338 0.8235277476230687 0.12048418350951762 0.2249417804793958 0.9569188047864321 0.06458823308085314 0.1504876258158798 1.5955673533130113e-07 6.797084858311722 0.5813984359879188 FGTIVNIQVAFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGTIVNIQVAFK 12 0 Q9P2N5;U3KPZ7 Q9P2N5 RBM27 RNA-binding protein 27 0 37522500.0 8616500.0 17529000.0 11377000.0 False True 13071860.450528529 14400812.995297903 9128330.963283759 1.0 1.101665141683458 0.6983191870683317 23.639961151307993 -6.839933008830472 1.2828622613772618 1.0540816548214962 0.68508331263212 0.9243128020405633 0.047121680034291985 0.16887892349690983 0.539935848013559 0.028804036749777398 0.06635192818152698 1.4456627511737893e-07 6.839933008830472 -0.3689983421893762 FGTLGLTVTYCCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGTLGLTVTYCCR 13 0 Q9UHI6 Q9UHI6 DDX20 Probable ATP-dependent RNA helicase DDX20 0 29956000.0 11667000.0 9045500.0 9243500.0 False True 17699691.971951064 7431259.852185927 7416518.173430028 1.0 0.419852495962209 0.4190196182613281 24.07722091749125 FGTTLK(ub)NCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGTTLKNCR 9 1 O14977;U3KQI8 O14977 AZIN1 Antizyme inhibitor 1 1 24198700.0 8066300.0 10042000.0 6090400.0 True False 10574997.414160315 8543772.743409418 5460223.83124208 1.0 0.8079219699826109 0.5163333490683069 23.334153974783376 -6.96505750361835 0.3570657866041038 1.0259836159210363 0.28832470686293316 0.9999143230956126 0.0018405295064063548 0.07794147568567665 0.014791285611046479 0.0039363067978908034 0.024949777787283665 1.0837834040391107e-07 6.96505750361835 -0.7376589090581032 FGTTLK(ub)NCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGTTLKNCR 9 1 O14977;U3KQI8 O14977 AZIN1 Antizyme inhibitor 1 1 16954900.0 6069500.0 8557200.0 2328200.0 True False 5876827.0447763335 11974134.585208474 1718374.5754971467 1.0 2.0375169277530096 0.2923983575498514 22.486606009710528 -6.7456531992211595 1.6659370318593087 1.6132476032518455 0.29005043156898125 0.6300417708561938 0.4359104923026116 0.307695692404462 1.6787457149366334 0.20682507907674957 0.504427374382962 1.796167362748642e-07 6.7456531992211595 -1.3231971716828643 FGTTLK(ub)NCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGTTLKNCR 9 1 O14977;U3KQI8 O14977 AZIN1 Antizyme inhibitor 1 1 177855000.0 21567000.0 78151000.0 78137000.0 True False 32718715.75889847 64204343.45345008 62693187.70133635 1.0 1.9623124552493627 1.9161261757129253 24.96361278643284 -10.320326886007608 5.575411096718383 0.9998474859009547 1.9392193154811566 0.998189634401501 0.018855469663680992 3.575155034897993e-05 4.358309936049417e-06 0.018259623684327073 0.006085576666023211 4.782699712069969e-11 10.320326886007608 0.9393718295802018 FGTTLK(ub)NCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGTTLKNCR 9 1 O14977;U3KQI8 O14977 AZIN1 Antizyme inhibitor 1 1 21695700.0 8066300.0 9125800.0 4503600.0 True False 11048629.09356114 8722591.981014982 3439942.4345534733 1.0 0.7894727850080773 0.31134563441524016 23.397364036306268 -6.957485112941785 0.4695380045116527 1.0126855182005383 0.06854732321608695 0.99966524818213 0.005271695110764993 0.0806120539205169 0.024545837092511943 0.00660516221185496 0.039463769902618524 1.10284603735029e-07 6.957485112941785 -0.9441381949844514 down FGTTLK(ub)NCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGTTLKNCR 9 1 O14977;U3KQI8 O14977 AZIN1 Antizyme inhibitor 1 1 16173700.0 6069500.0 4551800.0 5552400.0 True False 5047058.174440495 4527278.549938442 6713381.16860302 1.0 0.8970133478678054 1.330157279066285 22.267011285144804 -6.843985655371351 1.2638321233564753 0.9452113704922646 1.3455589105116839 0.9310854123190581 0.04850223065161655 0.16419048329525526 0.5077168480817262 0.030071961474069556 0.06936917984807936 1.4322352048316733e-07 6.843985655371351 0.4003475400194193 FGTTLK(ub)NCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGTTLKNCR 9 1 O14977;U3KQI8 O14977 AZIN1 Antizyme inhibitor 1 1 165319000.0 21567000.0 115700000.0 28052000.0 True False 27918906.64912717 109261193.2915259 22946823.8378265 1.0 3.9135197758520297 0.8219098307183849 24.73473910852529 -6.659559662685527 1.9744216101076548 2.876079233759006 0.8348032126632758 0.23373993063680598 1.2406418461355195 0.4854932823753966 3.637812250515121 0.5077392365811845 1.3752726274903093 2.189980951300261e-07 6.659559662685527 -2.0412760210957304 FGTVLTEHVAAAELGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGTVLTEHVAAAELGAR 17 0 H0Y8X4;O43598;O43598-2 H0Y8X4 DNPH1 2-deoxynucleoside 5-phosphate N-hydrolase 1 0 17940300.0 5261000.0 2952900.0 9726400.0 False True 5093992.4347258 4132008.369170074 7178764.054254559 1.0 0.8111532206059298 1.40926083935988 22.28036538633878 -6.821808651072252 1.363985811579957 0.8983944815205668 1.4228366551856244 0.8885036043817007 0.08335815799836765 0.19114022170497683 0.6982453686251235 0.04801807601634442 0.11062659581542567 1.5072710192816107e-07 6.821808651072252 0.5244421736650576 FGTVLTEHVAAAELGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGTVLTEHVAAAELGAR 17 0 H0Y8X4;O43598;O43598-2 H0Y8X4 DNPH1 2-deoxynucleoside 5-phosphate N-hydrolase 1 0 15814500.0 3738300.0 5876800.0 6199400.0 False True 5120450.533758923 5617143.544021221 4735229.400650776 1.0 1.0970018179040342 0.9247681174598993 22.287839323733795 -6.753885391783661 1.6353928578403176 1.0567698493956554 0.9243200014487577 0.6655625094162946 0.040771183861560104 0.2933085259885741 1.5445196146031763 0.019684348093703518 0.047596339621500304 1.7624410847387586e-07 6.753885391783661 -0.13244984794689774 FGTVLTEHVAAAELGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGTVLTEHVAAAELGAR 17 0 H0Y8X4;O43598;O43598-2 H0Y8X4 DNPH1 2-deoxynucleoside 5-phosphate N-hydrolase 1 0 7459400.0 5261000.0 0.0 2198400.0 False True 4374754.601817514 0.0 2658075.275746861 1.0 0.0 0.6075941435989461 22.060770661773056 -10.12000712889521 6.75699913241874 1.0000007881788537 0.30379707179947285 0.6364410105971443 0.248049270420126 2.9451307851880504e-06 3.834682322230762e-07 0.24017294530012545 0.08005755778133714 7.585651231655695e-11 10.12000712889521 -0.6962037163793808 FGVEQPEGDEDLTK(ub)EK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGVEQPEGDEDLTKEK 16 1 P24928;P24928-2 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 28472300.0 9975700.0 7429600.0 11067000.0 True False 9659026.863922108 10396278.024852164 8168220.697116626 1.0 1.0763276851091281 0.8456566911130703 23.20344641580614 -6.817513461215987 1.3824845316536678 1.0412464777225243 0.8408796826396019 0.878600013487389 0.03343122932708852 0.1967275083532246 0.7394598988962574 0.019005587646142425 0.04383893829257244 1.5222519490438737e-07 6.817513461215987 -0.20036679508292243 FGVEQPEGDEDLTK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGVEQPEGDEDLTKEK 16 1 P24928;P24928-2 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 58752000.0 15254000.0 23278000.0 20220000.0 True False 23141433.216777317 19123859.028155874 16223508.137259183 1.0 0.8263904335143452 0.7010589182305829 24.463974881755757 -6.974661995612178 0.09483860717563293 1.337739084182327 0.1865407583263171 0.9999997938153898 5.535647540007535e-05 0.0748166841586917 0.002774708308223236 0.012126904093988315 0.021360980589866657 1.0600784461521719e-07 6.974661995612178 -1.1511983258560097 FGVEQPEGDEDLTK(ub)EK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGVEQPEGDEDLTKEK 16 1 P24928;P24928-2 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 34665700.0 9975700.0 12507000.0 12183000.0 True False 8295236.5484415535 12439622.308554871 14730408.972172521 1.0 1.499610316825978 1.775767199181313 22.983851691240417 -10.050072394253315 0.12591489830319408 5.318107389004708e-21 2.318835172938549 0.9998407384117916 0.0040516764535244625 1.6703647269591615 0.05996263401606404 0.8470567336223846 0.307485393693993 8.911023843954354e-11 10.050072394253315 2.318835172938549 FGVEQPEGDEDLTK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGVEQPEGDEDLTKEK 16 1 P24928;P24928-2 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 62935000.0 15254000.0 17463000.0 30218000.0 True False 19746603.701292954 16491168.698789272 24718634.062863357 1.0 0.8351394978220723 1.2517916719645743 24.235101203848206 -6.799344171780484 1.4584995622161367 0.9089630716676139 1.25745643883863 0.8302638991651969 0.07058516115164021 0.2216944956763168 0.9310942590818787 0.03807323710351215 0.08858344823718886 1.5872883481251701e-07 6.799344171780484 0.3484933671710161 FGVFNYSPFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGVFNYSPFR 10 0 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;A0A087WYS3;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-18;Q9ULU4-21;Q9ULU4-8;Q9ULU4-23;Q9ULU4-15;Q9ULU4-17;Q9ULU4-6;Q9ULU4-3;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 0 8372200.0 1951900.0 3221800.0 3198500.0 False True 2558959.8022264866 2741119.998478038 2867549.9021784705 1.0 1.0711852511684858 1.1205920076132057 21.287126054105208 -6.975026272021391 0.06686823264340878 0.7751546505393617 1.4178552867880694 0.9999999383800744 1.0846241875140879e-05 0.07470209123090728 0.0019273062580817788 0.0074159791218819885 0.011055116774347295 1.059189649081522e-07 6.975026272021391 0.6427006362487077 FGVFNYSPFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGVFNYSPFR 10 0 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;A0A087WYS3;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-18;Q9ULU4-21;Q9ULU4-8;Q9ULU4-23;Q9ULU4-15;Q9ULU4-17;Q9ULU4-6;Q9ULU4-3;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 0 8370800.0 1951900.0 2473900.0 3945000.0 False True 2673570.1781141274 2364594.917906701 3013272.2498253505 1.0 0.884433458026761 1.1270593435294975 21.3503361156281 -6.777186875865227 1.5468860715725448 0.9343240611017186 1.1288126015216644 0.757290178064792 0.048816600229374785 0.25497056033455445 1.2048810490176698 0.02486112421775042 0.05879992703929132 1.670371702744929e-07 6.777186875865227 0.1944885404199458 FGVFNYSPFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGVFNYSPFR 10 0 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;A0A087WYS3;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-18;Q9ULU4-21;Q9ULU4-8;Q9ULU4-23;Q9ULU4-15;Q9ULU4-17;Q9ULU4-6;Q9ULU4-3;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 0 8509300.0 2450700.0 2979600.0 3079000.0 False True 2037865.6344182086 2963548.3033957067 3722804.664312493 1.0 1.4542412676004381 1.8268155669523907 20.958627500637014 -6.973390950927702 0.15734226336767215 0.6088881324396241 2.682030735571378 0.9999982022510016 0.0004532808218530806 0.07521695303555989 0.004844001583107541 0.01769106805175693 0.045155551848422265 1.0631855100816147e-07 6.973390950927702 2.073142603131754 FGVIFAGAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGVIFAGAQK 10 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 35045000.0 11324000.0 10143000.0 13578000.0 False True 14845873.661771975 8629703.937104333 12173078.809372928 1.0 0.5812863650676054 0.8199637883702677 23.823558660898705 -10.178958369447274 5.432777674342256 1.000010367613041 0.7006250767188862 0.6771816121546159 0.09743965003580925 1.223637844200474e-05 1.8493223378546692e-06 0.09434880113855755 0.03144851182072164 6.622799854211722e-11 10.178958369447274 -0.2993852908941548 FGVIFAGAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGVIFAGAQK 10 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 27104600.0 9299700.0 3692900.0 14112000.0 False True 9004486.113898426 5167494.228219089 10415643.849074725 1.0 0.573879970811778 1.1567171871138962 23.102212513186405 -6.7107141005414075 1.792689237184035 0.7382212864112387 1.155374947606213 0.4684742646915383 0.17954474078413957 0.37364497989366746 2.3411937019155387 0.07968887582008312 0.20226981847423237 1.9466411490214715e-07 6.7107141005414075 0.4171536611949742 FGVIFAGAQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGVIFAGAQK 10 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 37254300.0 7933300.0 13683000.0 15638000.0 False True 12035396.101918163 11241161.744233048 12547142.445621122 1.0 0.9340084571409717 1.042520108135153 23.52078028794079 -6.7420898392670505 1.6790310422524766 0.9608308261712468 1.0426134018790716 0.6143014132388316 0.02772587072146446 0.31404429937814093 1.7391402441162112 0.013059237956870723 0.03197314813784312 1.8109654329291758e-07 6.7420898392670505 0.08178257570782477 FGVIFAGAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGVIFAGAQK 10 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 34851000.0 11324000.0 10208000.0 13319000.0 False True 15510788.819593402 9756976.806658156 10173326.51341543 1.0 0.6290445263707694 0.6558871139141789 23.886768722421596 -10.748831593806075 6.898917691973474 1.0066149625363823 0.6424658201425854 0.9957903796116332 0.010958440476223519 0.00112318983123033 4.0891851473225795e-05 0.010688790794782878 0.003536821455401573 1.7830700537562377e-11 10.748831593806075 -0.3641491423937969 FGVIFAGAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGVIFAGAQK 10 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 23429600.0 9299700.0 6815300.0 7314600.0 False True 7733112.5965638505 6778584.626168861 8844049.041110815 1.0 0.8765661357602466 1.1436596752827057 22.88261778862068 -6.781049905969306 1.531883475215765 0.9302048593884219 1.1458420391537703 0.7710707532113463 0.05222194783976977 0.2489369385671088 1.1539330143817794 0.02684886319451406 0.06329392291643228 1.6555797053363518e-07 6.781049905969306 0.21563717976534835 FGVIFAGAQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGVIFAGAQK 10 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 40607300.0 7933300.0 21443000.0 11231000.0 False True 10269813.23872214 20249678.20008808 9187073.239791445 1.0 1.9717669376631939 0.8945706242399576 23.29190661003324 -6.66906374503653 1.9403999657153708 1.620788098559611 0.8989241544745347 0.2748761220656145 0.4128782197205334 0.4633688996454797 3.362541768901004 0.1713416118276037 0.45839017809603466 2.1425760942106532e-07 6.66906374503653 -0.7218639440850764 FGVLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGVLFR 6 0 Q9P1F3 Q9P1F3 ABRACL Costars family protein ABRACL 0 52381800.0 16232500.0 13016000.0 23133300.0 False True 21280964.69575362 11074063.535970632 20739688.02628274 1.0 0.5203741322018329 0.9745652193305463 24.3430602159075 -10.644053732904126 9.657582734527438 1.000092200444079 0.7474696757661896 0.29187577244157004 0.1854227348642207 0.0003682335331372099 1.3571854807746369e-05 0.17959958513671753 0.05984493034477998 2.2695840311717565e-11 10.644053732904126 -0.2526225246778895 FGVLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGVLFR 6 0 Q9P1F3 Q9P1F3 ABRACL Costars family protein ABRACL 0 44216400.0 15526500.0 5425200.0 23264700.0 False True 15033619.756276395 7591510.652044251 17170977.143960353 1.0 0.5049689146803694 1.1421718403374963 23.84168908369098 -6.69936185766848 1.8332645189747887 0.6924076631257354 1.140244977476316 0.41446220481440676 0.20898412558964624 0.39686912938938396 2.592723463660255 0.09096110010576813 0.23410203409263902 1.9981962625726113e-07 6.69936185766848 0.4478373143505805 FGVLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGVLFR 6 0 Q9P1F3 Q9P1F3 ABRACL Costars family protein ABRACL 0 50910600.0 16232500.0 13413600.0 21264500.0 False True 22234093.916818287 12820942.799156524 16242263.056124525 1.0 0.5766343727395395 0.7305115790591571 24.40627027743039 -10.247673175671581 4.7687085138574385 1.0000895328645503 0.6535729758985728 0.871099632045695 0.06282010642404388 5.9813266123379225e-05 9.436399347806767e-06 0.06084096688513489 0.02027510216522432 5.6536227295736785e-11 10.247673175671581 -0.3465165569659775 FGVLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGVLFR 6 0 Q9P1F3 Q9P1F3 ABRACL Costars family protein ABRACL 0 32376100.0 15526500.0 8113200.0 8736400.0 False True 12910972.690575864 8069492.581255883 10563140.847450381 1.0 0.625010429086111 0.8181522105736277 23.622094359125256 -10.088645933194789 4.781100851782761 1.000012229891515 0.7215813198264569 0.7347943378640043 0.07884980212116222 1.027946900988753e-05 1.9596576357143865e-06 0.0763493450662811 0.0254486642039172 8.153687579507579e-11 10.088645933194789 -0.27843091006505816 FGVPVIADGGIQNVGHIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGVPVIADGGIQNVGHIAK 19 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 36884400.0 13956000.0 6205400.0 16723000.0 False True 13512974.419128187 8683248.580733506 12342744.620753711 1.0 0.6425860296488093 0.9133995401694859 23.687841933798367 -9.830642925119843 6.786966284060306 1.0000000015614339 0.7779927849091381 0.47258775702583555 0.11055915270461769 4.299959952441051e-09 7.050923672485659e-10 0.1070484400965045 0.03568281309964388 1.4769203511753298e-10 9.830642925119843 -0.22200721665229572 FGVPVIADGGIQNVGHIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGVPVIADGGIQNVGHIAK 19 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 34635400.0 5776400.0 13729000.0 15130000.0 False True 7912091.181340474 13122407.38426819 11556605.612131199 1.0 1.6585258035467914 1.4606259391178134 22.91562762157258 -10.34039271850382 5.217610104842499 0.9997975651116675 1.5595758713323427 0.914238240477509 0.08079228133630104 0.00019031936737901338 2.4060044720253945e-05 0.07825461904688068 0.026075596676446284 4.566750463199887e-11 10.34039271850382 0.5597783062206751 FGVSSSSSGPSQTLTSTGNFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGVSSSSSGPSQTLTSTGNFK 21 0 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 5711900.0 1691800.0 1449700.0 2570400.0 False True 2217966.1834145053 1233410.4108863394 2304439.665017838 1.0 0.5560997368262549 1.038987736715719 21.08080593870472 -6.665051919441774 1.955566174707196 0.7154579841807376 1.0369739605596056 0.2571290194287884 0.188777731920616 0.4725241766636348 3.4790591429654905 0.07786078906228745 0.20932638971472262 2.162459988489965e-07 6.665051919441774 0.321515976378868 FGVSSSSSGPSQTLTSTGNFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGVSSSSSGPSQTLTSTGNFK 21 0 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 3876200.0 1691800.0 2184400.0 0.0 False True 2317304.1791759226 2087885.9851551754 0.0 1.0 0.9009978076756705 0.0 21.144016000227612 -7.115643336887156 0.9730140678530089 0.9982772219649539 8.507608250040124e-19 0.9896176896500508 0.04584078786896924 0.08540138864057414 0.15345595002975423 0.03799962722890516 0.06697728438602911 7.662256092034594e-08 7.115643336887156 -0.9982772219649539 down FGVVLDEIK(ub)PSSAPELQAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGVVLDEIKPSSAPELQAVR 20 1 M0QXB4;O14579-2;O14579;O14579-3;M0R061 M0QXB4 COPE Coatomer subunit epsilon 1 16354100.0 2675400.0 4163200.0 9515500.0 True False 2590470.891439919 5825587.470801189 7023105.091118948 1.0 2.2488527047540083 2.7111306729314912 21.30478294175169 -9.860526579943457 0.25506997070392706 4.759754239374481e-14 2.9644345854291525 0.9990635333861436 0.02211739444046597 1.2883125258793964 0.11178334122962329 1.1544398055868508 0.2008418579991761 1.3787115696793323e-10 9.860526579943457 2.964434585429105 FGVVLDEIK(ub)PSSAPELQAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGVVLDEIKPSSAPELQAVR 20 1 M0QXB4;O14579-2;O14579;O14579-3;M0R061 M0QXB4 COPE Coatomer subunit epsilon 1 14243600.0 2675400.0 4271800.0 7296400.0 True False 2224713.6403160207 4248786.96551409 8822043.505258096 1.0 1.9098129703158333 3.9654737335115744 21.085188217185966 -6.957591357862852 0.46814546925250117 0.9447142914476352 5.014581869513161 0.99967017356751 0.022527225157740062 0.0805730110277292 0.024397396474815442 0.028324822748301233 0.16968857639528906 1.1025762723316137e-07 6.957591357862852 4.069867578065526 FGVVLDEIKPSSAPELQAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGVVLDEIKPSSAPELQAVR 20 1 M0QXB4;O14579-2;O14579;O14579-3;M0R061 M0QXB4 COPE Coatomer subunit epsilon 0 11702500.0 1077100.0 6216100.0 4409300.0 False True 1412088.5306512373 5288682.1101680165 3953067.932992194 1.0 3.7452907486819846 2.7994476601046316 20.429399110289957 -10.535486589110926 5.7467867577578575 0.995135726786838 3.272369204393138 0.8850030245925441 0.38613882395876714 0.02401658047590395 0.0019412628535918968 0.37312176878948905 0.12462576954303475 2.9141601218103826e-11 10.535486589110926 2.2772334776062997 FGVVLDEIKPSSAPELQAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGVVLDEIKPSSAPELQAVR 20 1 M0QXB4;O14579-2;O14579;O14579-3;M0R061 M0QXB4 COPE Coatomer subunit epsilon 0 13150600.0 4413100.0 2840700.0 5896800.0 False True 4273008.556108812 3975006.324054805 4352251.179791932 1.0 0.9302593879368731 1.0185449251136727 22.02682077514343 -6.696115548350974 1.8445467347722426 0.9565307160750696 1.0182655818768123 0.39925556503399184 0.029459729579182796 0.40365277384144893 2.667176383532455 0.012754422699421748 0.03296135265965013 2.0131885498360627e-07 6.696115548350974 0.0617348658017427 FGVVLDEIKPSSAPELQAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGVVLDEIKPSSAPELQAVR 20 1 M0QXB4;O14579-2;O14579;O14579-3;M0R061 M0QXB4 COPE Coatomer subunit epsilon 0 11268800.0 1077100.0 4296200.0 5895500.0 False True 1475332.9775330334 4106379.678366455 4503104.321633808 1.0 2.783357886592426 3.052263041773552 20.49260917181285 -10.243360274549921 0.4161968525939606 6.417112095821535e-24 3.0716359589221236 0.9991594075217334 0.026404056355957124 1.609194007452569 0.19216200541532444 1.9102893812950215 0.06551280600162053 5.710047558334335e-11 10.243360274549921 3.0716359589221236 FGVVLDEIKPSSAPELQAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGVVLDEIKPSSAPELQAVR 20 1 M0QXB4;O14579-2;O14579;O14579-3;M0R061 M0QXB4 COPE Coatomer subunit epsilon 0 8988400.0 4413100.0 2291400.0 2283900.0 False True 3669688.1834785966 2279055.7733927104 2761452.930439529 1.0 0.6210488901082413 0.7525034260054959 21.807226050577707 -10.360554946716976 5.2603911265957795 1.0001355575553008 0.6867761580568545 0.8833141998920553 0.05366608955382363 8.535523649200333e-05 1.0375761992301715e-05 0.051984314393260685 0.01732065592482919 4.359584032755578e-11 10.360554946716976 -0.31335939949844627 FGVVVVGVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGVVVVGVGR 10 0 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 FGVVVVGVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGVVVVGVGR 10 0 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 43711000.0 0.0 0.0 43711000.0 False True 0.0 0.0 32261777.79810835 0.0 FGVVVVGVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGVVVVGVGR 10 0 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 164718000.0 0.0 71992000.0 92726000.0 False True 0.0 59144465.12393659 74398665.45675044 0.0 FGVVVVGVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGVVVVGVGR 10 0 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 FGVVVVGVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGVVVVGVGR 10 0 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 22548000.0 0.0 0.0 22548000.0 False True 0.0 0.0 27262682.54982726 0.0 FGVVVVGVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGVVVVGVGR 10 0 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 169649000.0 0.0 103210000.0 66439000.0 False True 0.0 97466272.77111854 54347783.72170816 0.0 FGYALSNGTVGVYDK(ub)TSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGYALSNGTVGVYDKTSR 18 1 Q9BXC9;H3BRL0;H3BQ79 Q9BXC9 BBS2 Bardet-Biedl syndrome 2 protein 1 8731000.0 1635900.0 1276000.0 5819100.0 True False 2240736.4385352237 1219622.1008322695 4444748.428126413 1.0 0.5442952057447418 1.983610545036684 21.095541534468918 -6.821563893179417 1.3650554414987641 0.7547564393430072 2.016108425687586 0.8879480982395812 0.20105512154412267 0.19145882575504197 0.7005774502242617 0.11572804593126682 0.26663482210696265 1.5081207202788214e-07 6.821563893179417 1.2613519863445788 FGYHIIMVEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGYHIIMVEGR 11 0 Q9Y237;Q9Y237-2 Q9Y237 PIN4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 0 25751500.0 8126700.0 6610800.0 11014000.0 False True 10654182.399074739 5624494.408696567 9874376.933748232 1.0 0.5279142216661341 0.9268075732029678 23.344916549302273 -10.091951859571587 7.415069428613055 1.0000000503904387 0.7273608974345512 0.38380988427452845 0.16284752884231316 1.357314423152331e-07 1.6476888457343667e-08 0.15767646998895812 0.05255881393144255 8.09185590352649e-11 10.091951859571587 -0.2726391529558875 FGYHIIMVEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGYHIIMVEGR 11 0 Q9Y237;Q9Y237-2 Q9Y237 PIN4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 0 23089300.0 8275600.0 4972200.0 9841500.0 False True 8012895.607834412 6957625.389680457 7263715.91132857 1.0 0.8683035110151454 0.9065032501143095 22.933892250680696 -9.133746008908618 9.141122918378723 1.0000000000127025 0.8874033789388233 0.9205357021674847 0.015594978185388903 0.0 0.0 0.015099772698224932 0.005033257566074976 7.349435640223083e-10 9.133746008908618 -0.11259662107387924 FGYHIIMVEGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FGYHIIMVEGR 11 0 Q9Y237;Q9Y237-2 Q9Y237 PIN4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 0 59718000.0 17446000.0 0.0 42272000.0 False True 26466857.473442897 0.0 33916920.671524234 1.0 0.0 1.28148650460512 24.65768357167716 -6.698506126390444 1.8362931531015945 0.378123802942341 1.2775551225774968 0.4104207321715123 0.4222303171731008 0.39865222166767483 2.612373964213711 0.18351529188340457 0.47280828878612763 2.0021373781682116e-07 6.698506126390444 0.8994313196351558 FGYHIIMVEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGYHIIMVEGR 11 0 Q9Y237;Q9Y237-2 Q9Y237 PIN4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 0 25224700.0 8126700.0 6605000.0 10493000.0 False True 11131360.60580976 6313169.2601858415 8014769.510118492 1.0 0.5671516253719089 0.7200170575675507 23.408126610825164 -10.156254608655383 5.598422865841294 1.0000067346229182 0.6435843414696949 0.878762294927418 0.06240705136501373 5.2459459359518e-06 7.905214242485592e-07 0.06042650892243549 0.020141789218532827 6.978231796457754e-11 10.156254608655383 -0.3564223931532233 FGYHIIMVEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGYHIIMVEGR 11 0 Q9Y237;Q9Y237-2 Q9Y237 PIN4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 0 15997400.0 8275600.0 3476500.0 4245300.0 False True 6881528.071241404 3457771.404468775 5132972.601950579 1.0 0.5024714523681373 0.7459059308937191 22.714297526114972 -10.132377128547642 5.139752252466429 1.0000130497755715 0.6241886916304461 0.760634408146121 0.09938170969971354 138800040.5160433 3.1559733501397305 21436.425661769077 0.03402100262847038 7.372637339450118e-11 10.132377128547642 -0.3758243581451254 FGYHIIMVEGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FGYHIIMVEGR 11 0 Q9Y237;Q9Y237-2 Q9Y237 PIN4 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 0 56144000.0 17446000.0 38698000.0 0.0 False True 22584190.912072744 36544422.28172408 0.0 1.0 1.618141753406303 0.0 24.42880989376961 -6.818512690893817 1.480877863811808 1.3387023895393304 1.0854957434726655e-18 0.8406999592787769 0.26609875758753776 0.20743264482858564 0.9107689581320475 0.1434051020638891 0.3154844570045744 1.5187535605750054e-07 6.818512690893817 -1.3387023895393304 FGYPFVIIAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGYPFVIIAGK 11 0 Q7L3T8 Q7L3T8 PARS2 Probable proline--tRNA ligase, mitochondrial 0 3785200.0 1084700.0 1243500.0 1457000.0 False True 1422052.2042497415 1057974.647125037 1306243.6165308866 1.0 0.7439773617053759 0.9185623513871249 20.439542997312287 -10.075321088048241 4.901544003746716 1.0000049526574817 0.8312698568053666 0.5546458601117473 0.07127402358285813 3.857580487869168e-06 7.276268380522568e-07 0.06901280224706433 0.023003592195472954 8.4077330072863e-11 10.075321088048241 -0.1687350958521151 FGYPFVIIAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGYPFVIIAGK 11 0 Q7L3T8 Q7L3T8 PARS2 Probable proline--tRNA ligase, mitochondrial 0 3527090.0 1084700.0 684090.0 1758300.0 False True 1485742.90291531 653864.6418168852 1343025.7533252002 1.0 0.44009272434273683 0.9039422303077661 20.50275305883518 -10.097617071565812 7.436255678295067 1.000000063899951 0.6720174773252559 0.3999874016153848 0.18936576784273068 2.0076703966414535e-07 2.424917827530469e-08 0.1833526545492885 0.06111753876638965 7.986986096638825e-11 10.097617071565812 -0.32798258657469526 FGYQFTQQGPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGYQFTQQGPR 11 0 Q9NYL9;H0YNJ8;H0YKU1 Q9NYL9 TMOD3 Tropomodulin-3 0 24346100.0 6331100.0 4886000.0 13129000.0 False True 8300133.410459613 4157027.845478831 11770537.022260817 1.0 0.5008386781157339 1.4181141965053103 22.98470309482731 -6.758921340063931 1.616447808515985 0.7096723060196469 1.4212975716894443 0.6865837506962884 0.20991780483286682 0.284731991833953 1.466046786133028 0.1024738764109284 0.24653199195704448 1.7421223801077022e-07 6.758921340063931 0.7116252656697973 FGYQFTQQGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FGYQFTQQGPR 11 0 Q9NYL9;H0YNJ8;H0YKU1 Q9NYL9 TMOD3 Tropomodulin-3 0 17663700.0 6331100.0 5400100.0 5932500.0 False True 8671878.76154432 5161505.726257318 4531365.683672728 1.0 0.5952004021488577 0.5225356359647452 23.0479131563502 -13.999999999999998 0.24157480173122184 3.699977628330357 0.4908837674551359 0.9995276002521923 0.00456553238933716 13.679588235508737 0.15555455859495615 17.83395722186959 0.03518126798300275 1.0000000000000041e-14 13.999999999999998 -3.209093860875221 FGYVDFESAEDLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FGYVDFESAEDLEK 14 0 P19338 P19338 NCL Nucleolin 0 15811100.0 2885400.0 7788900.0 5136800.0 False True 3782787.3422533516 6626826.4808944 4605293.211664964 1.0 1.751836907899479 1.2174338113655785 21.85101824370246 -10.155176634493248 5.773461043189299 0.999993575430349 1.4846353596325486 0.5230273943547221 0.21816915057863104 1.8042567639159863e-05 2.6405162045733417e-06 0.21124417166710122 0.07041379057059434 6.995574169746143e-11 10.155176634493248 0.4846417842021996 FGYVDFESAEDLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FGYVDFESAEDLEK 14 0 P19338 P19338 NCL Nucleolin 0 46389200.0 14219000.0 6302200.0 25868000.0 False True 13767625.6280871 8818701.325538825 19092394.77663442 1.0 0.6405390125910994 1.3867601641988543 23.714776437195795 -6.775715053198294 1.5525235879448358 0.7953315398434216 1.3919005788324152 0.7519513407245526 0.15175996636544647 0.25728898802346667 1.2245682269328764 0.07701458431107498 0.18238690994205528 1.6760421905270975e-07 6.775715053198294 0.5965690389889936 FGYVDFESAEDLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FGYVDFESAEDLEK 14 0 P19338 P19338 NCL Nucleolin 0 20206000.0 14219000.0 5987000.0 0.0 False True 11823728.508504715 5954746.842673543 0.0 1.0 0.5036268245156628 0.0 23.49518171263007 -7.91750708607141 0.5951762000877036 1.010001762457695 2.524300840550133e-18 0.9889122999588499 0.04298816562868394 0.1127100030548211 0.1610813767848197 0.04469431479275643 0.07710625308000281 1.2091854533709251e-08 7.91750708607141 -1.010001762457695 down FHADSVCK(ub)ASNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FHADSVCKASNR 12 1 Q9BW61 Q9BW61 DDA1 DET1- and DDB1-associated protein 1 1 2661240.0 1007600.0 905650.0 747990.0 True False 975614.2895323547 1267280.7679023577 552068.9797809946 1.0 1.2989567511457922 0.5658680748163499 19.89595136345087 -6.795990516236117 1.4721964253529918 1.1658017249913346 0.5567203758201849 0.8201599287873745 0.12763544306684402 0.2265489751589993 0.9697392408223803 0.0682173570156329 0.1590536539499252 1.5995929588219992e-07 6.795990516236117 -0.6090813491711498 FHADSVCK(ub)ASNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FHADSVCKASNR 12 1 Q9BW61 Q9BW61 DDA1 DET1- and DDB1-associated protein 1 1 2858650.0 1007600.0 1326300.0 524750.0 True False 837864.0442484943 1319154.9586500623 634472.7988301334 1.0 1.5744260273553718 0.7572502999567325 19.676356638885146 -6.717762949972115 1.7671504682417551 1.35029750549466 0.7586613421354689 0.5020622911413766 0.24178853585963545 0.3596689710221385 2.1937870249158595 0.10868707607635658 0.2735878310740309 1.9153010644442536e-07 6.717762949972115 -0.5916361633591911 FHADSVCK(ub)ASNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FHADSVCKASNR 12 1 Q9BW61 Q9BW61 DDA1 DET1- and DDB1-associated protein 1 1 2770170.0 731860.0 648510.0 1389800.0 True False 947407.1971173643 612419.8484138949 1136870.6605522356 1.0 0.6464167153018034 1.1999810261219714 19.85362510604167 -6.734174768189981 1.708081290010854 0.7882097818105861 1.199906453780683 0.5784773247864502 0.14859549825062907 0.3284666937773724 1.879251051303444 0.06888979597091589 0.17013861762957252 1.8442730999755954e-07 6.734174768189981 0.41169667197009685 FHAFLLYLGYTPQAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FHAFLLYLGYTPQAAR 16 0 Q9Y613 Q9Y613 FHOD1 FH1/FH2 domain-containing protein 1 0 14773000.0 2976400.0 4007700.0 7788900.0 False True 4515416.403986891 3292494.622696978 6249420.50100385 1.0 0.7291674406351244 1.3840186467600017 22.10642760603723 -6.794432818615825 1.4789778406113185 0.8494985527296404 1.3918187204950616 0.8152437523390608 0.11548305555772331 0.22881117834878653 0.9886443764690964 0.06145102097373737 0.14339625072006779 1.605340570393932e-07 6.794432818615825 0.5423201677654212 FHAIYWPAFLLGAGMSPPQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FHAIYWPAFLLGAGMSPPQR 20 0 Q96GW9 Q96GW9 MARS2 Methionine--tRNA ligase, mitochondrial 0 51966400.0 27943000.0 9125400.0 14898000.0 False True 42391573.90693645 7496901.07292438 11953403.76997463 1.0 0.1768488494761379 0.2819759369212455 25.3372741957279 -10.689519996233217 6.813973315273833 1.005904995121646 0.22941239387814794 0.9862334153655885 0.04291795373091022 0.0038464311220960347 0.00017526313758853743 0.04151659669422304 0.013851710004426315 2.0439958220778164e-11 10.689519996233217 -0.7764926012434982 FHAIYWPAFLLGAGMSPPQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FHAIYWPAFLLGAGMSPPQR 20 0 Q96GW9 Q96GW9 MARS2 Methionine--tRNA ligase, mitochondrial 0 48386300.0 27943000.0 11995000.0 8448300.0 False True 36172764.33887695 11327467.705547588 6910796.086878294 1.0 0.3131490753493038 0.19104970861878157 25.10840051782035 -13.999999999999998 0.24295768499951037 5.612327990306794 0.1385583274224128 0.9995299684083577 0.007719672336455604 13.729689139336761 0.15599257591526994 30.77701524379279 0.05864284699744648 1.0000000000000041e-14 13.999999999999998 -5.473769662884382 FHALGPIYYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FHALGPIYYR 10 0 Q9UL25 Q9UL25 RAB21 Ras-related protein Rab-21 0 3160270.0 1090900.0 685770.0 1383600.0 False True 1430180.464290628 583455.7891105236 1240438.3444283681 1.0 0.4079595573275564 0.8673299456957886 20.447765771230138 -9.930871579400565 6.7103835598461385 1.0000000242589937 0.6376447515116885 0.4534399267025554 0.18753717574106793 6.811548114232512e-08 1.0887034742926915e-08 0.18158210313886958 0.06052736320332509 1.172542034217374e-10 9.930871579400565 -0.36235527274730517 FHDFLGDSWGILFSHPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FHDFLGDSWGILFSHPR 17 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 26220920.0 12477000.0 10408920.0 3335000.0 False True 16357467.827439867 8855949.709652364 2989926.191578933 1.0 0.5414010165312013 0.18278661606555585 23.96344609736047 -7.991541905819315 0.3291912843521931 1.1009183623331527 8.522855441440121e-20 0.9988371213166951 0.011405328505708781 0.09936699412777802 0.06513850481657464 0.05368850727155072 0.0871926765915137 1.0196663659414453e-08 7.991541905819315 -1.1009183623331527 down FHDFLGDSWGILFSHPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FHDFLGDSWGILFSHPR 17 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 465518200.0 165458900.0 96358900.0 203700400.0 False True 160206497.787123 134835511.27502525 150345154.35898933 1.0 0.8416357210067106 0.9384460457949896 27.255357422046213 -10.268564766934 4.9774384307298405 1.0000251510802132 0.8900408834048132 0.6323686847312726 0.039522649594295634 1.1033417934240713e-05 1.6213552043386736e-06 0.03827639063236661 0.012755880306358717 5.3880948598093314e-11 10.268564766934 -0.10998426767539993 FHDFLGDSWGILFSHPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FHDFLGDSWGILFSHPR 17 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 1160848800.0 357976200.0 349966700.0 452905900.0 False True 543076066.9657613 287512408.08269256 363388850.3492919 1.0 0.5294146171623119 0.6691306659481315 29.016579045062883 -10.684026605787015 10.096760960198745 1.0002585479879733 0.5992726415552273 0.9164467925029456 0.057038838067176564 0.00033216999727986605 1.0395129065873917e-05 0.05526125227029101 0.018409205826766365 2.0700145314929718e-11 10.684026605787015 -0.400985906432746 FHDFLGDSWGILFSHPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FHDFLGDSWGILFSHPR 17 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 68676030.0 12477000.0 16551400.0 39647630.0 False True 17090084.078246817 15820104.419839494 30283676.36257116 1.0 0.9256890924238447 1.7720027721290068 24.026656158883362 -6.885501183645559 1.0485913773870414 0.949502723004608 1.8386975542725725 0.9778605598609209 0.056935057685045504 0.1228708712141859 0.24375891482801762 0.041595098030968045 0.10215592638001236 1.3016637679619177e-07 6.885501183645559 0.8891948312679645 FHDFLGDSWGILFSHPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FHDFLGDSWGILFSHPR 17 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 409548160.0 165458900.0 126215800.0 117873460.0 False True 137586406.42209944 125535850.43352537 142520255.5006991 1.0 0.9124146323612499 1.0358600039560826 27.03576269748049 -6.716160309042729 1.773314157689268 0.9464954497883682 1.0356247282147717 0.4942221378284536 0.036874785940924214 0.36284886603136374 2.2278275849184896 0.01652525073530457 0.04167022732578534 1.9223819982657113e-07 6.716160309042729 0.0891292784264035 FHDFLGDSWGILFSHPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FHDFLGDSWGILFSHPR 17 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 886162600.0 357976200.0 274432000.0 253754400.0 False True 463407247.6658443 259159617.95488387 207573702.94001743 1.0 0.5592480895805061 0.4479293407376649 28.787705367155333 -13.999999999999982 0.19323426901540947 3.389696154997056 0.370615879292405 0.9994879530413168 0.005394225426831629 12.405179124263535 0.139401721888294 11.174552433559079 0.07463169004461863 1.0000000000000409e-14 13.999999999999982 -3.019080275704651 FHFGDSLCTHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FHFGDSLCTHK 11 0 O75439;G3V0E4 O75439 PMPCB Mitochondrial-processing peptidase subunit beta 0 7548200.0 1893000.0 2075100.0 3580100.0 False True 2481741.331838074 1765503.1686764474 3209665.594744149 1.0 0.7113969316733131 1.2933118990152555 21.242921322696663 -6.771828036337148 1.5672568674651441 0.8348558376471683 1.296830645532019 0.7375990369536508 0.12169461303031386 0.2634701248127324 1.277408674333158 0.06119265865706684 0.14543289540680512 1.691110412804029e-07 6.771828036337148 0.4619748078848508 FHFGDSLCTHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FHFGDSLCTHK 11 0 O75439;G3V0E4 O75439 PMPCB Mitochondrial-processing peptidase subunit beta 0 6816100.0 1893000.0 2225600.0 2697500.0 False True 2592893.2564014755 2127265.632924998 2060406.0567563705 1.0 0.8204215995676217 0.7946358962790034 21.306131384219555 -13.999999999904475 0.2733624629854186 2.4114180711826796 0.7863517775679902 0.9995905982326896 0.001848144570661547 15.050492422357548 0.1655408597131116 11.829044055984838 0.01053231522954852 1.0000000002199552e-14 13.999999999904475 -1.6250662936146894 FHGGNLFFLPGGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FHGGNLFFLPGGAR 14 0 H3BRW3;P55789 H3BRW3 GFER FAD-linked sulfhydryl oxidase ALR 0 4854800.0 1307100.0 1657200.0 1890500.0 False True 1713620.7579744041 1409952.2197150069 1694889.1949565108 1.0 0.8227912816495345 0.9890690148734921 20.70861643074192 -10.511480424542382 7.407868266591064 1.000022623604438 0.905930148267336 0.29910536236408025 0.06788260033088694 2.5369965568036626e-05 1.673088086665167e-06 0.06574284320457753 0.02190901504823159 3.079779156822806e-11 10.511480424542382 -0.09409247533710208 FHGGNLFFLPGGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FHGGNLFFLPGGAR 14 0 H3BRW3;P55789 H3BRW3 GFER FAD-linked sulfhydryl oxidase ALR 0 4736400.0 1307100.0 1451700.0 1977600.0 False True 1790370.1930493233 1387559.0938700645 1510531.6099504721 1.0 0.7750123964624328 0.8436979211420876 20.77182649226481 -10.105744946087365 6.923856905631614 1.0000001226114497 0.8093551588022602 0.911285228754085 0.028040748030082788 5.308491249600107e-08 6.8364980221433536e-09 0.027150355334980298 0.009050112511309062 7.838898730708e-11 10.105744946087365 -0.1906449638091895 FHGGNLFFLPGGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FHGGNLFFLPGGAR 14 0 H3BRW3;P55789 H3BRW3 GFER FAD-linked sulfhydryl oxidase ALR 0 4081330.0 2194600.0 802830.0 1083900.0 False True 1824907.1372645362 798504.9954407226 1310538.4786126388 1.0 0.43755924843258054 0.7181398175564616 20.799391621800904 -10.49341713944588 6.308491450564399 1.0002689636744422 0.5778495329945299 0.7511366887590982 0.11454653768220224 0.0004335837136508626 3.481749204018589e-05 0.11097816882125039 0.036969736067407465 3.2105753026027216e-11 10.49341713944588 -0.4224194306799123 FHGTVK(ub)AENGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FHGTVKAENGK 11 1 P04406;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 22631800.0 14656000.0 4865400.0 3110400.0 True False 19214157.92890589 4139501.2851806628 2788565.6450636 1.0 0.21544016139022015 0.14513077572181635 24.195666415089903 -13.978269524716131 0.34144278519313803 9.999999999603805 0.13422707312089308 0.9997373240612213 0.006280022685526794 19.526647915876957 0.18736997986188628 126.85124260951784 0.02162405844716831 1.0513092250430798e-14 13.978269524716131 -9.865772926482911 FHGTVK(ub)AENGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FHGTVKAENGK 11 1 P04406;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 17877500.0 7307000.0 6836000.0 3734500.0 True False 7075043.284649586 9565650.449269053 2756322.4174014726 1.0 1.3520271275263047 0.38958382394376945 22.754307543609087 -6.807703049412439 1.4240438792373007 1.1923789484819363 0.3735963498493494 0.8537815584733305 0.15203936254996145 0.2099454937798912 0.8395152942102765 0.08395894026296893 0.19443525310601584 1.5570298931288218e-07 6.807703049412439 -0.8187825986325868 down FHHTFSTEIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FHHTFSTEIAK 11 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 93551000.0 45837000.0 0.0 47714000.0 False True 60092750.88613942 0.0 42777012.985006675 1.0 0.0 0.7118498047469703 25.840687630332805 -10.580411111081776 8.707797220912354 1.0001429688900458 0.35592490445418035 0.5218807291468062 0.2906114658549854 0.0008067840679584486 3.887522744325494e-05 0.28144348749413095 0.09379444728944031 2.627779310317443e-11 10.580411111081776 -0.6442180644358655 FHHTFSTEIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FHHTFSTEIAK 11 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 19514000.0 19514000.0 0.0 0.0 False True 29604164.664494116 0.0 0.0 1.0 0.0 0.0 24.819296810274246 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 FHINIHILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FHINIHILK 9 0 Q9Y4K3 Q9Y4K3 TRAF6 TNF receptor-associated factor 6 0 23812400.0 6734700.0 8933400.0 8144300.0 False True 10217032.272520667 7339164.973027222 6534575.5352265015 1.0 0.7183264941588131 0.6395766755872585 23.284472863668928 -13.999999999999998 0.17879323098909236 2.4561287300527597 0.5762360351785509 0.9994996419430814 0.0034608938721540235 12.189378923484169 0.13403176087025254 6.164359514807912 0.05940615158690547 1.0000000000000041e-14 13.999999999999998 -1.8798926948742087 FHINIHILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FHINIHILK 9 0 Q9Y4K3 Q9Y4K3 TRAF6 TNF receptor-associated factor 6 0 20948000.0 6734700.0 9024500.0 5188800.0 False True 8718201.910783906 8522278.64182694 4244491.641583992 1.0 0.9775271012346457 0.48685401932866507 23.055599185761377 -6.916472535781312 0.8504729896190976 1.0122629674726382 0.4138093386439941 0.9931437123187329 0.019606042416862857 0.10029220734233764 0.1166962012395738 0.01658432074870536 0.048119879426410356 1.2120693360411372e-07 6.916472535781312 -0.5984536288286442 down FHKPLATFSFANHTIQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FHKPLATFSFANHTIQIR 18 1 C9JSX1;C9JES0;H7BXH9;Q8WXB1-2;Q8WXB1 C9JSX1 METTL21A Protein N-lysine methyltransferase METTL21A 0 55133000.0 23597000.0 16143000.0 15393000.0 False True 35798374.17177759 13262155.52416531 12350566.80300843 1.0 0.370468096135517 0.34500356758506817 25.0933907313777 FHKPLATFSFANHTIQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FHKPLATFSFANHTIQIR 18 1 C9JSX1;C9JES0;H7BXH9;Q8WXB1-2;Q8WXB1 C9JSX1 METTL21A Protein N-lysine methyltransferase METTL21A 0 50776700.0 23597000.0 18829000.0 8350700.0 False True 30546781.666409507 17781149.597978782 6830958.285417727 1.0 0.5820956784305583 0.22362284708144323 24.86451705347015 -7.790792170838722 0.3139286783331522 1.0971581114836988 4.971545898734108e-10 0.9992836381829704 0.008491550042650793 0.11843348114681104 0.049834470152721536 0.03969201988716769 0.08161976132898834 1.6188545459718808e-08 7.790792170838722 -1.0971581109865443 down FHLGLFTDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FHLGLFTDR 9 0 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 0 20871800.0 9348400.0 5124800.0 6398600.0 False True 12255842.93003439 4360199.816313935 5736534.25170523 1.0 0.3557649882758167 0.46806525544213495 23.54696637723387 -9.929388098101153 5.774617800351454 1.0000003864252285 0.4119151218605058 0.9733789742372237 0.04584639209101786 2.280986722052966e-07 4.2268282978764036e-08 0.04439060736582115 0.014796859420764488 1.176554100849217e-10 9.929388098101153 -0.5880852645647228 FHLGLFTDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FHLGLFTDR 9 0 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 0 22995700.0 6642700.0 6932200.0 9420800.0 False True 10077461.546419758 5695094.748474185 7558774.750716684 1.0 0.5651318759432522 0.7500673374836252 23.26462894237494 -10.217608753193987 5.473699590816562 1.0000178632142576 0.6575996067134099 0.8204839657447047 0.07549958602010437 1.6459219819996535e-05 2.3527125707499448e-06 0.07310596984985267 0.024367386608436816 6.058864593900713e-11 10.217608753193987 -0.3424182565008477 FHLGLFTDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FHLGLFTDR 9 0 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 0 27269800.0 9348400.0 8154500.0 9766900.0 False True 12804756.111010885 7794207.226674564 7460159.375619576 1.0 0.6086962655987083 0.5826084707075788 23.61017643875676 -13.999999999999998 0.3847832522335255 6.984645519070473 0.580505904077862 0.9998151146918351 0.0025958263761801416 24.65028261474954 0.20277258541400509 122.44110399327998 0.006970934730772684 1.0000000000000041e-14 13.999999999999998 -6.404139614992611 FHLGLFTDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FHLGLFTDR 9 0 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 0 27439700.0 6642700.0 11147000.0 9650000.0 False True 8599106.0971928 10526659.650999475 7893799.017361542 1.0 1.2241574335774192 0.9179790234171542 23.03575526446739 -6.710477097239472 1.7937145196640982 1.1377410561033512 0.9186946037357558 0.467287209568345 0.09445166499028329 0.37410948169569697 2.3466797661094807 0.04190135573120638 0.10637920076059201 1.9477037604728956e-07 6.710477097239472 -0.21904645236759535 FHLISPLIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FHLISPLIQK 10 0 O43847-2;G3V1R5;O43847;F5H7V1;H0Y5G9 O43847-2 NRD1 Nardilysin 0 6298200.0 1223100.0 2047700.0 3027400.0 False True 1603495.9445172485 1742191.1418720828 2714153.6888713813 1.0 1.0864955086597303 1.6926476790613334 20.6127892743153 -6.932644777776058 0.7247516109792083 0.9916262782527954 1.825906563605753 0.997033061789653 0.01678534818552518 0.09128742296061781 0.07112105977489842 0.015540379264694097 0.05407071375349408 1.1677643753573113e-07 6.932644777776058 0.8342802853529576 FHLISPLIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FHLISPLIQK 10 0 O43847-2;G3V1R5;O43847;F5H7V1;H0Y5G9 O43847-2 NRD1 Nardilysin 0 5825700.0 1223100.0 1630400.0 2972200.0 False True 1675313.1230346793 1558363.5369881887 2270227.5743804574 1.0 0.9301924013854516 1.3551064234894454 20.675999335838192 -6.864728836862262 1.1615446476511129 0.9615314220230986 1.377627823845471 0.9591372437523945 0.037608796739043056 0.14201313883663594 0.36142470861338777 0.025199471409257573 0.05917565968800506 1.3654354158643523e-07 6.864728836862262 0.4160964018223723 FHMVDGNVSGEFTDLVPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FHMVDGNVSGEFTDLVPEK 19 0 O95433;O95433-2;G3V438;H0YJ63 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 0 11298800.0 4446900.0 1463300.0 5388600.0 False True 4305735.593609995 2047603.3210086932 3977164.0054651364 1.0 0.4755524988685966 0.9236897898160581 22.037828298606453 -10.174763879390145 7.773882606428699 1.000000115446464 0.6996211443423284 0.3746244843284201 0.18295128292240798 3.6605319878680587e-07 3.904823377306795e-08 0.17714188397116465 0.059047272660480606 6.68707386798334e-11 10.174763879390145 -0.3003789711041356 FHMVDGNVSGEFTDLVPEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FHMVDGNVSGEFTDLVPEK 19 0 O95433;O95433-2;G3V438;H0YJ63 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 0 9794100.0 4446900.0 2901000.0 2446200.0 False True 3697794.381072481 2885371.737196585 2957689.1100491164 1.0 0.7802953436150046 0.7998522376442386 21.81823357404073 -10.712547610797268 6.747493951389294 1.0024125893496443 0.7900737906296218 0.993532891057756 0.007984068554217709 0.00029268937200565507 1.2468946808547276e-05 0.007808449910075893 0.00257684704545529 1.938440117160738e-11 10.712547610797268 -0.21233879872002248 FHPNGSTLASAGFDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FHPNGSTLASAGFDR 15 0 Q96DI7;Q96DI7-2 Q96DI7 SNRNP40 U5 small nuclear ribonucleoprotein 40 kDa protein 0 13519700.0 4010800.0 3406000.0 6102900.0 False True 5258197.640642447 2897838.076484015 5471430.451150544 1.0 0.5511086259074044 1.0405524525856438 22.326136939088418 -6.665504652260329 1.953240450992492 0.7123738502229351 1.038542468160274 0.2592918525748379 0.1908792191617605 0.4715396748955418 3.4637881716363825 0.07879482030569848 0.21176707597559385 2.1602068940278948e-07 6.665504652260329 0.32616861793733887 FHPNGSTLASAGFDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FHPNGSTLASAGFDR 15 0 Q96DI7;Q96DI7-2 Q96DI7 SNRNP40 U5 small nuclear ribonucleoprotein 40 kDa protein 0 10392200.0 4010800.0 2712400.0 3669000.0 False True 5493701.14779453 2592557.19929267 2802457.7654269254 1.0 0.47191449435385896 0.5101219906277545 22.38934700061131 -9.956791307186172 6.018023570745283 1.0000002683167495 0.49101824397711724 0.9957915469828614 0.01559814503707036 5.615633496659671e-08 9.760358788094334e-09 0.015102846866453908 0.0050342796633074845 1.1046092935646057e-10 9.956791307186172 -0.5089820243396322 FHQLDIDDLQSIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FHQLDIDDLQSIR 13 0 P16152;E9PQ63;A8MTM1;P16152-2;O75828 P16152;O75828 CBR1;CBR3 Carbonyl reductase [NADPH] 1;Carbonyl reductase [NADPH] 3 0 11452000.0 1483000.0 3625800.0 6343200.0 False True 1944227.3613924289 3084844.7732577007 5686866.512270904 1.0 1.586668737677047 2.925000761329708 20.89076550944759 -6.957393249214418 0.4707426972326581 0.9649048590652561 3.6016976522556265 0.9996609407140665 0.014833988367878343 0.08064590100614989 0.024674893662348325 0.018530527684930947 0.1104539990952792 1.1030793404835214e-07 6.957393249214418 2.6367927931903705 FHQLDIDDLQSIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FHQLDIDDLQSIR 13 0 P16152;E9PQ63;A8MTM1;P16152-2;O75828 P16152;O75828 CBR1;CBR3 Carbonyl reductase [NADPH] 1;Carbonyl reductase [NADPH] 3 0 9981500.0 1938100.0 1032800.0 7010600.0 False True 1876576.0763623042 1445202.425980848 5174313.546508168 1.0 0.7701272781769322 2.7573161630294494 20.83967134756711 -6.878091115171578 1.0903340091731735 0.8608088690007332 2.893122443155708 0.9721152902381474 0.1482117087210083 0.12933706842273288 0.2825868026959384 0.10488126098831402 0.2524560603892862 1.324063716907624e-07 6.878091115171578 2.032313574154975 up FHQLDIDDLQSIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FHQLDIDDLQSIR 13 0 P16152;E9PQ63;A8MTM1;P16152-2;O75828 P16152;O75828 CBR1;CBR3 Carbonyl reductase [NADPH] 1;Carbonyl reductase [NADPH] 3 0 9445000.0 1483000.0 3789100.0 4172900.0 False True 2031305.176568089 3621685.033121907 3187346.9635731815 1.0 1.7829349695454335 1.5691128050774905 20.95397557097048 -10.105374636766129 4.643047462681118 0.9999525568346913 1.6760238873249989 0.930205451057372 0.08729253315361875 60795481.76622892 3.634960711981055 30836.38957556205 0.029882555936815533 7.845585564899499e-11 10.105374636766129 0.6760713304903075 FHTITTSYYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FHTITTSYYR 10 0 P61026 P61026 RAB10 Ras-related protein Rab-10 0 9927900.0 3596400.0 3998700.0 2332800.0 False True 2990565.9475340266 3977158.209420194 2820577.694351479 1.0 1.3299015233888074 0.9431585003759181 21.511987101385635 -6.680786805819257 1.89881377611759 1.2085879860726445 0.9446139461403983 0.3277362324725094 0.1397968745179693 0.43684604213375 3.0457975453318373 0.05905724814444327 0.15561856714799982 2.0855144061680747e-07 6.680786805819257 -0.2639740399322462 FHVEEEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FHVEEEGK 8 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 42081100.0 2283100.0 26292000.0 13506000.0 False True 2993166.209571849 22369336.085413318 12108528.678700175 1.0 7.473469403028271 4.045391345117522 21.513240962783378 -9.43072400828567 10.247715147314576 0.9998712320623032 5.759430374072979 0.7198945310842492 1.399507008693393 0.0 0.0 1.3550668335002756 0.4516889445000918 3.7091636217427274e-10 9.43072400828567 4.7595591420106755 FHVEEEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FHVEEEGK 8 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 32088800.0 12178000.0 3677800.0 16233000.0 False True 11791416.055900168 5146364.719473627 11981090.32043863 1.0 0.43645010023189695 1.0160857918709054 23.491233649208567 -10.872979574258036 12.17197174623618 1.007784605054727 0.7262679460515612 0.22920280763792722 0.23663528020346405 0.04907695346734506 0.0005121405576580634 0.2249383033576095 0.07637370827942848 1.3397396965936142e-11 10.872979574258036 -0.2815166590031658 FHVEEEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FHVEEEGK 8 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 36827100.0 2283100.0 17995000.0 16549000.0 False True 3127223.768457587 17199921.398492698 12640467.037353564 1.0 5.500060971644528 4.0420730888688885 21.57645102430627 -9.861112063147251 6.687568215250647 0.9999999087834907 4.771067030256861 0.8991924123329741 0.5952210606607327 8.081763176147304e-07 1.3868821950439552e-07 0.5763203138113223 0.19210677127082953 1.3768541465865848e-10 9.861112063147251 3.771067121473371 FHVEEEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FHVEEEGK 8 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 14091900.0 12178000.0 1264400.0 649500.0 False True 10126546.576873917 1257588.4262362518 785307.4470513053 1.0 0.12418729491732329 0.07754938379928246 23.271638924642843 -13.329072340244984 0.4245086472684486 9.99999999939993 0.07623575857640802 0.9998582105755222 0.005052151938117137 17.007980754006457 0.21721399667565316 139.27178381726804 0.011191222143053238 4.687352986052717e-14 13.329072340244984 -9.923764240823523 FHVELHFSPGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FHVELHFSPGAK 12 0 A0A087WZV0;O43314-2;O43314;H0Y9S9;A0A087WWN8 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 0 12620500.0 3453400.0 4226400.0 4940700.0 False True 4527440.8427731665 3595837.594378168 4429483.758540932 1.0 0.7942318230657722 0.9783636964823966 22.110264359832502 -10.309431342648947 6.8737993809651625 1.0000020367541522 0.8862977598016953 0.3370527149672895 0.07517152254224534 2.34640637305112e-06 2.3573735118134212e-07 0.0727858173320476 0.024261504576264303 4.904205469504711e-11 10.309431342648947 -0.11370427695245688 FHVELHFSPGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FHVELHFSPGAK 12 0 A0A087WZV0;O43314-2;O43314;H0Y9S9;A0A087WWN8 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 0 12362100.0 3913200.0 4214300.0 4234600.0 False True 3788977.6079773833 5897091.967284168 3125431.2247230583 1.0 1.5563807911844931 0.8248745566990731 21.85337718318625 -6.70337852299856 1.8189880158296243 1.3443418484119152 0.8269186973468484 0.43357049888429733 0.2347132210656052 0.38852465379305173 2.501543140080452 0.10285538942196547 0.26340299590375155 1.9798007160973973e-07 6.70337852299856 -0.5174231510650668 FHVELHFSPGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FHVELHFSPGAK 12 0 A0A087WZV0;O43314-2;O43314;H0Y9S9;A0A087WWN8 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 0 48310000.0 14367000.0 14708000.0 19235000.0 False True 21795789.36839123 12083242.4858715 15433193.819000002 1.0 0.5543842565938403 0.7080814352785766 24.37754611829304 -10.330438056152012 5.526708123971015 1.0000734985543704 0.6312328459362028 0.8847339789267329 0.06274661044718234 5.6835979169803264e-05 6.885697250921061e-06 0.060766199620138864 0.020251381441072244 4.672635926837958e-11 10.330438056152012 -0.3688406526181677 FHVELHFSPGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FHVELHFSPGAK 12 0 A0A087WZV0;O43314-2;O43314;H0Y9S9;A0A087WWN8 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 0 16065100.0 3453400.0 7534100.0 5077600.0 False True 4730215.304625914 7201218.550063005 3878375.456454551 1.0 1.5223870556210353 0.8199152061137034 22.173474421355394 -6.707590992559244 1.8039952813461135 1.3219392369494154 0.8216920530543861 0.45360411325594285 0.22021532242837746 0.3799150058134767 2.4086576471603185 0.09720330417526028 0.24764735077512262 1.960690332304329e-07 6.707590992559244 -0.5002471838950293 FHVELHFSPGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FHVELHFSPGAK 12 0 A0A087WZV0;O43314-2;O43314;H0Y9S9;A0A087WWN8 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 0 8366200.0 3913200.0 2366800.0 2086200.0 False True 3253999.184153641 2354049.5786269833 2522414.7745010504 1.0 0.723432750103552 0.7751737575057585 21.633782458620527 -10.589533622871748 6.430032659373509 1.000575223323165 0.7493032538046566 0.9690417674607287 0.021123177818828862 0.00017457200341667136 1.1143949607687695e-05 0.02049787002562284 0.006817476325941832 2.573157544084073e-11 10.589533622871748 -0.2512719695185085 FHVELHFSPGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FHVELHFSPGAK 12 0 A0A087WZV0;O43314-2;O43314;H0Y9S9;A0A087WWN8 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 0 45973000.0 14367000.0 17785000.0 13821000.0 False True 18598364.715909004 16795249.11572851 11305719.81543564 1.0 0.9030497773474614 0.6078878432663894 24.14867244038549 -6.951119276179918 0.5464165402146023 1.0041714179596577 0.4929848503724465 0.9992862238406226 0.004455181561572825 0.08303936085582403 0.034126065105625984 0.004858124185450155 0.024470088393176787 1.1191304792837661e-07 6.951119276179918 -0.5111865675872111 FHVLLNILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FHVLLNILR 9 0 Q96BD8;K7EP61;Q96BD8-2 Q96BD8 SKA1 Spindle and kinetochore-associated protein 1 0 83608700.0 12625000.0 36427000.0 34556700.0 False True 19153048.01113243 29926317.244549956 27726553.098260302 1.0 1.5624832782310012 1.447631368236776 24.191070664749766 -10.081951580189854 4.520682425484689 0.9999713664368709 1.5050573232039894 0.9626637255061439 0.04688809617093889 7261168.44339278 8096870.18958699 2089.5206333069646 0.016051042098709622 8.280344767370161e-11 10.081951580189854 0.5050859567671185 FHVLLNILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FHVLLNILR 9 0 Q96BD8;K7EP61;Q96BD8-2 Q96BD8 SKA1 Spindle and kinetochore-associated protein 1 0 73053300.0 12625000.0 36850000.0 23578300.0 False True 16343311.375955416 34799265.10624665 19287291.33378816 1.0 2.129266481298519 1.1801336271524498 23.962196986842216 -6.603507835996715 2.1771558014872583 1.7576965051210702 1.1832865336549105 0.030888629379357546 0.48766167513277403 0.6307568068038135 5.655361684884764 0.18556273469362236 0.5422138723857187 2.4916794133540037e-07 6.603507835996715 -0.5744099714661597 FHYGTAFGGSK(ub)VK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FHYGTAFGGSKVK 13 1 Q9NW08;Q9NW08-2 Q9NW08 POLR3B DNA-directed RNA polymerase III subunit RPC2 1 9261000.0 1952600.0 3036100.0 4272300.0 True False 1890615.7817992044 4248430.563052343 3153256.463747305 1.0 2.2471147252401145 1.6678462615743683 20.850424772371994 -10.165434022476479 5.319962978166439 0.9999652259051423 1.957480493407575 0.7846140985219484 0.23648536001234963 9.754403047229965e-05 1.5302017475040183e-05 0.22898423804365003 0.07632532174563751 6.832285053925763e-11 10.165434022476479 0.9575152675024327 FHYGTAFGGSK(ub)VK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FHYGTAFGGSKVK 13 1 Q9NW08;Q9NW08-2 Q9NW08 POLR3B DNA-directed RNA polymerase III subunit RPC2 1 25025200.0 8707200.0 16318000.0 0.0 True False 13209458.981586715 13405925.406884084 0.0 1.0 1.0148731621462492 0.0 23.6550680436982 -7.012508597264059 1.1031279896752912 1.026721848951951 4.4348503286404584e-21 0.9847725940824533 0.0586084065188836 0.08958807910944674 0.2124845636718681 0.04477153117303213 0.08154905091062331 9.716087174865653e-08 7.012508597264059 -1.026721848951951 down FHYGTAFGGSK(ub)VK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FHYGTAFGGSKVK 13 1 Q9NW08;Q9NW08-2 Q9NW08 POLR3B DNA-directed RNA polymerase III subunit RPC2 1 6019800.0 1952600.0 4067200.0 0.0 True False 1623673.4148467768 4045289.186324005 0.0 1.0 2.4914426443976434 0.0 20.63083004780627 -6.745836480609293 1.6736121136036635 1.8826025519281304 5.155358526716887e-07 0.6252656826260002 0.6266646293162094 0.30854470157142666 1.7004668837039503 0.29640890322321567 0.7204306541647474 1.7954095023439126e-07 6.745836480609293 -1.8826020363922777 FHYGTAFGGSK(ub)VK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FHYGTAFGGSKVK 13 1 Q9NW08;Q9NW08-2 Q9NW08 POLR3B DNA-directed RNA polymerase III subunit RPC2 1 29059700.0 8707200.0 9469500.0 10883000.0 True False 11271642.0445718 8942514.000640502 8902405.669009905 1.0 0.7933639096485539 0.7898055699255574 23.42619436579065 FIAEVQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FIAEVQKR 8 1 Q9Y5V3;Q9Y5V3-2 Q9Y5V3 MAGED1 Melanoma-associated antigen D1 1 5885240.0 604940.0 3097600.0 2182700.0 True False 783106.7551501349 2925215.8369907625 1785470.996393267 1.0 3.7353985491160127 2.279984158802157 19.578849467300945 -9.723784367579269 6.321874750004516 0.999999983370685 3.0076913539619836 0.7172926610454052 0.594170436772514 1.4282246131499004e-07 2.983277205906523e-08 0.5753030687479327 0.19176768386753407 1.8889289922086408e-10 9.723784367579269 2.0076913705912984 FIAVGYVDDTQFVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIAVGYVDDTQFVR 14 0 O78179;A0A140T912;A0A1W2PRZ0;A0A140T930;A0A140T937;A0A140T9M5;A0A140T9Z4;D9J307;A0A140T953;A0A140TA13;Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913;A0A140T955;A0A140T933;A0A1W2PPQ2;A0A1W2PRT9;A0A140T975;A0A140T941;A0A1W2PQS8;Q9GJ45;A0A1W2PS39;A0A140T9Z6;Q5RJ27;B0UXQ0;Q5SRN5;P04439;P04439-2;A0A1W2PS24;Q5SRN7;Q5SUL5;A0A0G2JIF2;A0A0G2JL56;A0A0G2JI36;A0A1W2PQD0;A0A1W2PSE7 O78179;D9J307;Q53Z42;Q5SRN5 HLA-C;HLA-B;HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 0 4137600.0 1367400.0 1698100.0 1072100.0 False True 1792674.6419204364 1444750.0991419572 961169.3763093764 1.0 0.805918745854653 0.5361649871276729 20.77368224209205 -6.9664931088975965 0.3314282522940061 1.032322075957071 0.30091201222444997 0.9999406963892882 0.0014646813786251933 0.07745788122381378 0.013092923686303357 0.0039163564346567665 0.023501636409028626 1.0802067607642953e-07 6.9664931088975965 -0.7314100637326211 FIAVGYVDDTQFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIAVGYVDDTQFVR 14 0 O78179;A0A140T912;A0A1W2PRZ0;A0A140T930;A0A140T937;A0A140T9M5;A0A140T9Z4;D9J307;A0A140T953;A0A140TA13;Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913;A0A140T955;A0A140T933;A0A1W2PPQ2;A0A1W2PRT9;A0A140T975;A0A140T941;A0A1W2PQS8;Q9GJ45;A0A1W2PS39;A0A140T9Z6;Q5RJ27;B0UXQ0;Q5SRN5;P04439;P04439-2;A0A1W2PS24;Q5SRN7;Q5SUL5;A0A0G2JIF2;A0A0G2JL56;A0A0G2JI36;A0A1W2PQD0;A0A1W2PSE7 O78179;D9J307;Q53Z42;Q5SRN5 HLA-C;HLA-B;HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 0 6018100.0 1884200.0 1773600.0 2360300.0 False True 1824387.1023589373 2481807.729201812 1742066.622517789 1.0 1.3603514988638254 0.9548777341526326 20.798980445428043 -6.672205355719733 1.9292077878129037 1.229565222389686 0.9564861402503159 0.2890439802113155 0.15299055368103376 0.4560480627118393 3.274282114084202 0.0637900540057042 0.16996398111657102 2.1271329953962474e-07 6.672205355719733 -0.27307908213937016 FIAVGYVDDTQFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIAVGYVDDTQFVR 14 0 O78179;A0A140T912;A0A1W2PRZ0;A0A140T930;A0A140T937;A0A140T9M5;A0A140T9Z4;D9J307;A0A140T953;A0A140TA13;Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913;A0A140T955;A0A140T933;A0A1W2PPQ2;A0A1W2PRT9;A0A140T975;A0A140T941;A0A1W2PQS8;Q9GJ45;A0A1W2PS39;A0A140T9Z6;Q5RJ27;B0UXQ0;Q5SRN5;P04439;P04439-2;A0A1W2PS24;Q5SRN7;Q5SUL5;A0A0G2JIF2;A0A0G2JL56;A0A0G2JI36;A0A1W2PQD0;A0A1W2PSE7 O78179;D9J307;Q53Z42;Q5SRN5 HLA-C;HLA-B;HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 0 5665600.0 1367400.0 1874600.0 2423600.0 False True 1872964.732595553 1791773.9735267803 1851195.5956088018 1.0 0.95665120775859 0.9883771773125789 20.836892303614942 -9.988420322272178 4.569210042762222 1.000000656127751 0.9725141925336825 0.5001875701761823 0.012952072842940344 17832320.94726263 3.0123382155123966 123.1084858070629 0.004433839037703326 1.0270218366875113e-10 9.988420322272178 -0.027486463594068478 FIAYQFTDTPLQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIAYQFTDTPLQIK 14 0 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 5227000.0 1606400.0 1765500.0 1855100.0 False True 2106005.9563997295 1502094.2818650976 1663152.047375735 1.0 0.7132431308185689 0.7897185866553461 21.00607808605637 -9.856622271293887 6.063664416849867 1.0000000289935236 0.7514808587368005 0.9336886573782375 0.03122097410836915 1.2247825389236869e-08 2.302919930538916e-09 0.03022958179691702 0.010076526064425093 1.3911620718531645e-10 9.856622271293887 -0.2485191702567231 FIAYQFTDTPLQIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIAYQFTDTPLQIK 14 0 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 6341000.0 2357500.0 1163500.0 2820000.0 False True 2282662.4529302553 1628091.6175723434 2081357.4018134023 1.0 0.7132423874070216 0.911811292616463 21.12228610716645 -10.080053344987396 5.220497339548028 1.0000029536567168 0.8125268406475745 0.5430633215688891 0.08106541609209446 2.7868332410721087e-06 4.912276221359541e-07 0.07849248839737483 0.026163750539685525 8.316616106912307e-11 10.080053344987396 -0.18747611300914224 FIAYQFTDTPLQIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIAYQFTDTPLQIK 14 0 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 7031000.0 1606400.0 2289000.0 3135600.0 False True 2200329.4913277 2187864.4112892337 2395035.8597090915 1.0 0.9943349029826688 1.0884896417326586 21.06928814757926 -6.892595990433469 1.0068736857662284 0.9952513002709776 1.0970128189873758 0.9825093788241522 0.0057016201851604826 0.11706310544550855 0.2097342008781436 0.004299216640135937 0.010823471218870334 1.2805720233615462e-07 6.892595990433469 0.10176151871639816 FIAYQFTDTPLQIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIAYQFTDTPLQIK 14 0 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 5006310.0 2357500.0 917510.0 1731300.0 False True 1960365.7049581427 912567.191518523 2093306.8253732442 1.0 0.4655086493354096 1.0678144491504151 20.902691382600725 -6.672564262881087 1.9284240255153786 0.6595921688840959 1.0654028069384671 0.2904398799929835 0.22690666513046498 0.45522824417699737 3.2662187964048632 0.09464763294337382 0.2520192576843968 2.1253758284883677e-07 6.672564262881087 0.40581063805437123 FICHVVGITYQHIDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FICHVVGITYQHIDR 15 0 Q9UBQ5-2;Q9UBQ5;A0A087WVB9;K7EQM4;B4DQ48;K7EK53 Q9UBQ5-2 EIF3K Eukaryotic translation initiation factor 3 subunit K 0 24830200.0 9220900.0 10946000.0 4663300.0 False True 12088689.195322623 9312899.467173826 4180786.449532241 1.0 0.7703812478508579 0.34584282728932086 23.527154482501498 -6.961551771053659 0.4129823437212104 1.0202450790960849 0.08014715479630424 0.9998234916343826 0.0036001607382736586 0.07915137706063026 0.01911698998143903 0.005472072309695081 0.035412325917465244 1.0925673774662032e-07 6.961551771053659 -0.9400979242997807 down FICHVVGITYQHIDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FICHVVGITYQHIDR 15 0 Q9UBQ5-2;Q9UBQ5;A0A087WVB9;K7EQM4;B4DQ48;K7EK53 Q9UBQ5-2 EIF3K Eukaryotic translation initiation factor 3 subunit K 0 15872600.0 4805600.0 5737900.0 5329100.0 False True 7290446.536419647 4713926.914582673 4275801.049172493 1.0 0.6465896006553382 0.5864937117106063 22.797575750974993 -13.999999999999998 0.24926319931454613 3.4487075794249926 0.562160181618087 0.9995413091304357 0.003906926066874598 13.968891680357334 0.15798500107971916 17.119496478658554 0.027847965472133102 1.0000000000000041e-14 13.999999999999998 -2.886547397806906 FICHVVGITYQHIDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FICHVVGITYQHIDR 15 0 Q9UBQ5-2;Q9UBQ5;A0A087WVB9;K7EQM4;B4DQ48;K7EK53 Q9UBQ5-2 EIF3K Eukaryotic translation initiation factor 3 subunit K 0 42024900.0 9220900.0 11152000.0 21652000.0 False True 12630115.91545293 10659267.765267598 16538243.536937522 1.0 0.8439564479551608 1.3094292758392663 23.59036454402439 -6.816296955449134 1.3876555869913545 0.9155599646079164 1.318817482732703 0.875659227552936 0.06820974607892621 0.19835989026694537 0.7514793158182864 0.038634404684515754 0.08915294211929306 1.5265219187551182e-07 6.816296955449134 0.4032575181247866 FICHVVGITYQHIDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FICHVVGITYQHIDR 15 0 Q9UBQ5-2;Q9UBQ5;A0A087WVB9;K7EQM4;B4DQ48;K7EK53 Q9UBQ5-2 EIF3K Eukaryotic translation initiation factor 3 subunit K 0 16975300.0 4805600.0 7578100.0 4591600.0 False True 6220943.932537931 7156372.073314714 3755975.9137945366 1.0 1.15036755690469 0.6037630228668895 22.568702073067442 -6.833374852043154 1.312896995942155 1.0801756856619393 0.5880282311207385 0.9124321668801088 0.06822481894565016 0.17668477167019264 0.5944397237979597 0.040787334321990124 0.09385914405854882 1.4676589521874906e-07 6.833374852043154 -0.4921474545412008 FICIYPAYLNNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FICIYPAYLNNK 12 0 A0A087WYR0;P09132;A0A2U3TZN1;A0A087WWU9;D6RBG4;A0A2R8Y4M3;P09132-2 A0A087WYR0 SRP19 Signal recognition particle 19 kDa protein 0 32550900.0 10671000.0 12242000.0 9637900.0 False True 13989784.338111006 10415541.318942243 8640662.561264938 1.0 0.7445104990337985 0.6176408693968228 23.737870386775967 -13.99999999759335 0.0912042725010557 2.3015426496576175 0.30640029623150755 0.999836733992668 0.0020318035194039456 12.152934731033637 0.0880393415400753 3.054327270578624 0.27934310229224363 1.0000000055415185e-14 13.99999999759335 -1.99514235342611 FICIYPAYLNNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FICIYPAYLNNK 12 0 A0A087WYR0;P09132;A0A2U3TZN1;A0A087WWU9;D6RBG4;A0A2R8Y4M3;P09132-2 A0A087WYR0 SRP19 Signal recognition particle 19 kDa protein 0 18573000.0 11957000.0 3078500.0 3537500.0 False True 11577431.579930883 4307761.104165418 2610922.6272747866 1.0 0.37208262250780977 0.2255182947313409 23.464811895268596 -13.999999999999895 0.2044025483426579 4.550527286104003 0.13435783998349782 0.9994876455301291 0.007603641790059083 12.621413337803116 0.1433348307549555 17.95020163973213 0.09035142980274238 1.0000000000002414e-14 13.999999999999895 -4.416169446120506 FICIYPAYLNNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FICIYPAYLNNK 12 0 A0A087WYR0;P09132;A0A2U3TZN1;A0A087WWU9;D6RBG4;A0A2R8Y4M3;P09132-2 A0A087WYR0 SRP19 Signal recognition particle 19 kDa protein 0 34217700.0 10671000.0 8067700.0 15479000.0 False True 14616357.072931956 7711242.3376837615 11823179.000011811 1.0 0.5275762147302913 0.8089005311663579 23.80108044829886 -10.266160329327192 5.878050742276163 1.0000161168191024 0.6682383729483236 0.6496495673703901 0.11485017125094552 2.42586670577082e-05 3.02852657324373e-06 0.1112085969619219 0.037067733380330856 5.418008358224816e-11 10.266160329327192 -0.33177774387077885 FICTTSAIQNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FICTTSAIQNR 11 0 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 0 31672700.0 9028900.0 9224800.0 13419000.0 False True 11836975.335991967 7848495.7979887705 12030530.604137234 1.0 0.6630490961761429 1.0163517505655972 23.496797145074158 -11.031160751611502 11.95078252140867 1.377857233939276 0.83970042337087 0.2153658704790825 0.14423520467083975 0.045885213386884414 0.00011964229814423581 0.004412994468431246 0.04655171213558172 9.307632950044392e-12 11.031160751611502 -0.538156810568406 FICTTSAIQNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FICTTSAIQNR 11 0 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 0 8573500.0 5624400.0 0.0 2949100.0 False True 5445856.500640911 0.0 2176642.2388964174 1.0 0.0 0.3996877697089986 22.37672753691681 -10.703293838056819 6.692630701808661 1.008268561478503 0.19984388485450694 0.8423646368513281 0.16317184870301285 0.02001395553116667 0.0008872831324357918 0.15706879123927164 0.05266348771638707 1.9801868035625946e-11 10.703293838056819 -0.808424676623996 FICTTSAIQNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FICTTSAIQNR 11 0 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 0 30650900.0 9028900.0 7555000.0 14067000.0 False True 12367128.326848013 7221195.118955947 10744664.318958987 1.0 0.583902335943206 0.868808347014012 23.56000720659705 -10.061105792610995 5.481117837422004 1.0000019543268002 0.7263553414784489 0.5515719841629352 0.11631239196309856 2.7777793230481224e-06 4.757949326524069e-07 0.11261979302700353 0.03753966308580416 8.687487793562616e-11 10.061105792610995 -0.27364661284835123 FIDFFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIDFFK 6 0 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 9307800.0 2555900.0 3038300.0 3713600.0 False True 3350809.651370807 2584997.483200642 3329352.295366568 1.0 0.7714545892343143 0.9935963667779634 21.676078303367834 -10.717244763750802 8.757251575782702 1.0003924505556507 0.8825254780196581 0.2716026393622464 0.09068900092279848 0.0006971574621952467 2.2509923290242655e-05 0.08809712634598904 0.029269749188182294 1.9175877040341854e-11 10.717244763750802 -0.11786697253599265 FIDK(ub)QLELLAQDYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIDKQLELLAQDYK 14 1 O95140;O95140-2 O95140 MFN2 Mitofusin-2 1 13513100.0 2702500.0 4699200.0 6111400.0 True False 3543003.671047225 3998097.6773381294 5479050.952688299 1.0 1.1284486409116221 1.5464423583475504 21.75654152961497 -6.949609290926644 0.5631149152469102 0.9946197315110797 1.700355026279932 0.9991702767943589 0.006719889838287346 0.0836429772486576 0.036614326760195194 0.007176537015893909 0.03477062118124207 1.1230283221716531e-07 6.949609290926644 0.7057352947688523 FIDK(ub)QLELLAQDYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIDKQLELLAQDYK 14 1 O95140;O95140-2 O95140 MFN2 Mitofusin-2 1 25262400.0 7388500.0 5331900.0 12542000.0 True False 7153956.111760435 7460955.475491179 9256873.94806513 1.0 1.0429132299576267 1.2939517385139805 22.770309837008753 -6.9363728838191365 0.692479685526522 0.9969289590007391 1.3549890429107763 0.9976492642251581 0.006285736341982134 0.0894608175137377 0.06243995027603629 0.005962033875710765 0.02197369986279663 1.157782860710384e-07 6.9363728838191365 0.3580600839100372 FIDK(ub)QLELLAQDYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FIDKQLELLAQDYK 14 1 O95140;O95140-2 O95140 MFN2 Mitofusin-2 1 94812900.0 8227000.0 34990000.0 51595900.0 True False 12480960.474264264 28745761.121882234 41397947.74971363 1.0 2.3031689893703278 3.3168879778985105 23.573225625506193 -7.461486753561828 0.174434069930382 3.3369718819004723e-13 5.151455137818881 0.9999757762970863 0.004667411951703302 0.13082942629048244 0.015203960973062664 0.13955588959745377 0.26863313466754096 3.455518691123215e-08 7.461486753561828 5.151455137818547 FIDK(ub)QLELLAQDYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIDKQLELLAQDYK 14 1 O95140;O95140-2 O95140 MFN2 Mitofusin-2 1 15826600.0 7388500.0 6325700.0 2112400.0 True False 6143865.116048045 6291622.198546856 2554093.07336594 1.0 1.0240495322908152 0.4157143793236177 22.55071511244303 -6.897692504844152 0.9757105342967956 1.0269184367116289 0.3547626133102948 0.9853838155872492 0.034005397663480603 0.11312484216111517 0.18714038688756732 0.026247675361952136 0.06753681226616876 1.2656321405936825e-07 6.897692504844152 -0.6721558234013341 down FIDPLAK(ub)EEENVGIDITEPLYMQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FIDPLAKEEENVGIDITEPLYMQR 24 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 44144000.0 11863000.0 15619000.0 16662000.0 True False 17997038.301470418 12831667.418196004 13368748.39678597 1.0 0.7129877262720286 0.7428304687051591 24.10125617191411 -9.97332651536023 6.011961686013031 1.0000001829752314 0.7279090976914221 0.9910585063330176 0.012183248581231002 2.987439381015743e-08 5.116715647417868e-09 0.011796387624401704 0.003932126571462128 1.0633432648929479e-10 9.97332651536023 -0.2720910852838093 FIDTTLAITSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIDTTLAITSR 11 0 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 0 18903100.0 5263200.0 7573800.0 6066100.0 False True 6900106.168901303 6443818.562441172 5438438.162140011 1.0 0.9338723788748913 0.7881673164176788 22.718187129500347 -6.9581072990505 0.4613342049604352 1.0041909268703058 0.7119619505296103 0.999693430186017 0.0015493901213548345 0.08038428834721933 0.023682773753736917 0.0019833654321950523 0.012034991028468988 1.1012671911348909e-07 6.9581072990505 -0.29222897634069545 FIDTTLAITSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIDTTLAITSR 11 0 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 0 29386000.0 13228000.0 5723000.0 10435000.0 False True 12808084.38064111 8008223.745050727 7701760.456710217 1.0 0.6252475785648965 0.6013202464805049 23.610551381795105 -13.999999999999998 0.3911552337072078 6.96908228460966 0.5996163417407449 0.999824879068236 0.002415885540776066 25.507422709896613 0.20512315132183412 128.78759494918435 0.0062764132100371324 1.0000000000000041e-14 13.999999999999998 -6.369465942868914 FIDTTLAITSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FIDTTLAITSR 11 0 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 0 99572000.0 21379000.0 46182000.0 32011000.0 False True 32433506.014257465 37940461.27838708 25684011.819080252 1.0 1.1697921668323124 0.7918974842802934 24.950981649645268 -6.784551113679581 1.517908731677947 1.0955756186720558 0.7884543625531117 0.7831966523126355 0.07195662591948179 0.24358945297563905 1.1087373295029859 0.037324898406796585 0.08775067732511901 1.642286361711256e-07 6.784551113679581 -0.30712125611894403 FIDTTLAITSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIDTTLAITSR 11 0 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 0 21104800.0 5263200.0 5577600.0 10264000.0 False True 7209147.2726319395 5331163.18934331 7839854.593715438 1.0 0.7394998309414466 1.0874870906685248 22.78139719102324 -6.70634685567104 1.8082796706945052 0.8392568267116743 1.0865833814107715 0.44774050608229543 0.10983798264028054 0.382451765161266 2.4354341440956593 0.0483807135321173 0.12345487462713324 1.9663152358545856e-07 6.70634685567104 0.24732655469909715 FIDTTLAITSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIDTTLAITSR 11 0 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 0 24941800.0 13228000.0 6336500.0 5377300.0 False True 10999668.099760896 6302364.016803233 6501668.568173944 1.0 0.5729594711080628 0.5910786133915508 23.39095665722938 -10.361984515949368 8.940465404695377 1.0000008260401188 0.5820190422583468 0.9985926174686678 0.007397108861905467 1.2179450477180757e-07 8.690419328510395e-09 0.0071622340504743824 0.0023874066193536 4.3452571619030615e-11 10.361984515949368 -0.417981783781772 FIDTTLAITSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FIDTTLAITSR 11 0 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 0 79650000.0 21379000.0 35080000.0 23191000.0 False True 27675536.943093155 33127767.162201677 18970475.959754556 1.0 1.1970053997622332 0.6854600869627906 24.722107971737717 -6.802311857279398 1.4465859385947324 1.1083797744162192 0.6779995469992535 0.838799991325631 0.08458219405410325 0.21747557435650508 0.8982273613173646 0.045994506190763736 0.10681292079546936 1.5764788285151675e-07 6.802311857279398 -0.4303802274169657 FIDTTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIDTTSK 7 0 P39023;G5E9G0;Q92901 P39023 RPL3;RPL3L 60S ribosomal protein L3;60S ribosomal protein L3-like 0 7333650.0 312650.0 3604600.0 3416400.0 False True 409887.17770690663 3066807.7306207498 3062903.700422865 1.0 7.482077745827163 7.47255309999724 18.64486733401673 -10.032892604666774 4.986542579424932 0.999902615549135 7.477315422967814 0.9999983783051466 0.003888420570506787 672173.1806284413 0.15959442614472155 752.2626532197442 0.0013311097579043285 9.27059044587563e-11 10.032892604666774 6.477412807418679 FIDTTSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIDTTSK 7 0 P39023;G5E9G0;Q92901 P39023 RPL3;RPL3L 60S ribosomal protein L3;60S ribosomal protein L3-like 0 4597410.0 2168100.0 583210.0 1846100.0 False True 2099274.852257941 816088.7943999721 1362551.0281871336 1.0 0.3887479495703967 0.6490579481393773 21.001459636397414 -10.367323102134993 5.901971880042242 1.000088754715164 0.5189029488549104 0.8199595795564399 0.10627111190643906 0.00012413226599881504 1.3306699472224407e-05 0.10291539266823001 0.0342988538830483 4.292169833238629e-11 10.367323102134993 -0.4811858058602536 FIDTTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIDTTSK 7 0 P39023;G5E9G0;Q92901 P39023 RPL3;RPL3L 60S ribosomal protein L3;60S ribosomal protein L3-like 0 5831950.0 312650.0 2866800.0 2652500.0 False True 428245.1540485588 2740135.2967601456 2026034.1299522785 1.0 6.398520265449265 4.731014725557283 18.708077395539622 -9.808713868056387 6.968945507921777 0.9999999772275286 5.564767495503402 0.909022662805368 0.6807562860003856 2.4032369078133995e-07 3.9462843387915044e-08 0.6591394396260809 0.21971314654205687 1.55341012650228e-10 9.808713868056387 4.564767518275873 FIDTTSK(ub)FGHGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIDTTSKFGHGR 12 1 P39023;G5E9G0;Q92901 P39023 RPL3;RPL3L 60S ribosomal protein L3;60S ribosomal protein L3-like 1 13091900.0 5078400.0 3146600.0 4866900.0 True False 4917188.971775614 4403053.789302225 3592112.8861296605 1.0 0.8954412398172014 0.7305216266342793 22.22940236955181 -6.964408987085656 0.3680583882534146 1.0129649135811132 0.607274851951726 0.9999004316189727 0.0011068904936226344 0.07816212828580987 0.015570864722062256 0.002180394773812204 0.014021281805652406 1.0854029882557144e-07 6.964408987085656 -0.40569006162938714 FIDTTSK(ub)FGHGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FIDTTSKFGHGR 12 1 P39023;G5E9G0;Q92901 P39023 RPL3;RPL3L 60S ribosomal protein L3;60S ribosomal protein L3-like 1 52114300.0 6252700.0 5123600.0 40738000.0 True False 9485803.033600615 4209253.549130485 32686116.443900328 1.0 0.4437424574620057 3.445793290048249 23.17733848144836 -6.858840904527451 1.191498389295226 0.6990550211599994 3.5880359423860884 0.952221301003928 0.2850317409788914 0.14800503328168307 0.3999127135866984 0.1866595321631182 0.43518930075569195 1.3840733148855022e-07 6.858840904527451 2.888980921226089 up FIDTTSK(ub)FGHGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIDTTSKFGHGR 12 1 P39023;G5E9G0;Q92901 P39023 RPL3;RPL3L 60S ribosomal protein L3;60S ribosomal protein L3-like 1 5337300.0 1439300.0 1966300.0 1931700.0 True False 1971448.1056199924 1879422.3643154297 1475472.2446103012 1.0 0.9533207386782205 0.748420534329148 20.91082430424363 -6.942746147540811 0.6335022779073916 1.0022362152636617 0.6883955977997145 0.9985019011176455 0.004229241164153668 0.08653591085740375 0.04907042757224784 0.0042081736469753534 0.017433226913783607 1.1409164776457584e-07 6.942746147540811 -0.3138406174639472 FIDTTSK(ub)FGHGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIDTTSKFGHGR 12 1 P39023;G5E9G0;Q92901 P39023 RPL3;RPL3L 60S ribosomal protein L3;60S ribosomal protein L3-like 1 21020600.0 5078400.0 10645600.0 5296600.0 True False 4222914.611265931 10588250.039813833 6404094.571288596 1.0 2.507332260890713 1.5165105527361817 22.009807644986086 -10.530051741909762 5.324127474584416 0.9968151986381019 2.0119214068134514 0.5817168518088078 0.4045012685085859 0.015316188048161306 0.0013519223573913103 0.39228688460832317 0.130552223037792 2.9508576401005925e-11 10.530051741909762 1.0151062081753497 FIDTTSK(ub)FGHGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FIDTTSKFGHGR 12 1 P39023;G5E9G0;Q92901 P39023 RPL3;RPL3L 60S ribosomal protein L3;60S ribosomal protein L3-like 1 72027600.0 6252700.0 7847900.0 57927000.0 True False 8094243.409143481 7411157.466141461 47384880.38121271 1.0 0.9156084258313276 5.854145716409447 22.94846480354081 -6.903012431479763 0.9420131905805232 0.8112977876660334 6.405472160580956 0.9880067222581415 0.2528033149915708 0.10922217603402415 0.1651722023750403 0.2000741316409991 0.5288933149364763 1.2502232426403195e-07 6.903012431479763 5.594174372914923 up FIEIAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIEIAAR 7 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4;A0A1W2PPE9 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 39256500.0 16574000.0 12723000.0 9959500.0 False True 21728674.50284433 10824777.993865566 8928986.478269977 1.0 0.4981793984924658 0.4109310246743838 24.373096833829724 -13.999999999999998 0.24610917866990994 4.422646256904889 0.37452816013904694 0.9995355295910106 0.005594366374699993 13.847098950945895 0.15699014979657397 23.376001433337432 0.04115463670761043 1.0000000000000041e-14 13.999999999999998 -4.048118096765842 FIEIAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FIEIAAR 7 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4;A0A1W2PPE9 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 70434000.0 13849000.0 46409000.0 10176000.0 False True 21009945.497518633 38126951.35482796 8164709.139700764 1.0 1.8147096744887283 0.3886116287481589 24.324569083692197 -6.751709693729163 1.6431718853692863 1.4780485810779067 0.38533710228260915 0.6564911433582867 0.3423805324219736 0.2970431490935452 1.5784246505839588 0.1645534734877048 0.39883107885084407 1.7712925918680746e-07 6.751709693729163 -1.0927114787952976 FIEIAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIEIAAR 7 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4;A0A1W2PPE9 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 52447000.0 16574000.0 17629000.0 18244000.0 False True 22701855.69550879 16850092.48869283 13935142.94697432 1.0 0.7422341466132375 0.6138327691745117 24.436306895352615 -13.999999999963759 0.09065093609325561 2.316196258832884 0.2959086341166026 0.9998393499823305 0.0020352282080641705 12.157867941852182 0.08763902757919592 3.0768926980436873 0.28548028036370876 1.0000000000834485e-14 13.999999999963759 -2.0202876247162815 FIEIAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FIEIAAR 7 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4;A0A1W2PPE9 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 41241000.0 13849000.0 17175000.0 10217000.0 False True 17927803.50460248 16219196.151961623 8357610.83527284 1.0 0.9046951093477671 0.46618152821271436 24.095695405784646 -6.941675348651271 0.643789405208448 1.004815186597449 0.34186307370540947 0.9983752011557137 0.009370185011189098 0.08701058796368792 0.05119112124593744 0.009241409996406318 0.037472210385199975 1.1437329984451005e-07 6.941675348651271 -0.6629521128920396 down FIEK(ub)AQNMSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIEKAQNMSK 10 1 Q9HCN4-2;Q9HCN4-4;Q9HCN4;Q9HCN4-5;Q9HCN4-3 Q9HCN4-2 GPN1 GPN-loop GTPase 1 1 3586980.0 1047210.0 900370.0 1639400.0 True False 1013966.8917637717 1259892.4363675227 1209991.9590542165 1.0 1.2425380420222294 1.1933249190705466 19.9515791152867 -10.07901864111772 4.49029647370281 0.9999840470883641 1.217931480558488 0.9631631021474569 0.02009117335451471 13956140.520371813 0.36091258661868136 2301.9496387792174 0.006877743027014289 8.336454014903751e-11 10.07901864111772 0.2179474334701239 FIEK(ub)AQNMSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIEKAQNMSK 10 1 Q9HCN4-2;Q9HCN4-4;Q9HCN4;Q9HCN4-5;Q9HCN4-3 Q9HCN4-2 GPN1 GPN-loop GTPase 1 1 4222790.0 1047210.0 2530430.0 645150.0 True False 870801.5142690205 2516798.07133897 780047.8821634314 1.0 2.890208652716519 0.8957814948429772 19.731984390720978 -6.658341431223807 1.9792487655348836 2.2183845153132284 0.9041945318897633 0.22844041990946806 0.8051321492337242 0.4883496338510907 3.6759919698697328 0.3288892091872225 0.892110976990605 2.1961326505544202e-07 6.658341431223807 -1.3141899834234652 FIEK(ub)AQNMSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FIEKAQNMSK 10 1 Q9HCN4-2;Q9HCN4-4;Q9HCN4;Q9HCN4-5;Q9HCN4-3 Q9HCN4-2 GPN1 GPN-loop GTPase 1 1 10637000.0 1245100.0 2991300.0 6400600.0 True False 1611806.4945902636 2824831.525435969 5235756.475702 1.0 1.752587258406641 3.2483778253002873 20.620247120849996 -6.960166949093173 0.4330742139728739 0.942486324897507 4.116132008743015 0.9997763419485063 0.013975072328720297 0.07964153560975323 0.02091132597575561 0.01956503705399078 0.12411086129991956 1.0960567750384577e-07 6.960166949093173 3.173645683845508 FIFNYVYHPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIFNYVYHPK 10 0 J3QQW9;Q15022 J3QQW9 SUZ12 Polycomb protein SUZ12 0 21536800.0 6907500.0 7490600.0 7138700.0 False True 9055799.392325154 6373031.678130114 6400055.8032457335 1.0 0.7037514196186035 0.7067355984795578 23.110410568692814 -10.42904505424056 5.929296353349977 1.0001213674702796 0.7052435090490805 0.9999231293461616 0.0012182859184234718 1.9553935366720167e-06 1.882936345115895e-07 0.0011800827262697712 0.000393200089414356 3.723530758874569e-11 10.42904505424056 -0.29487785842119907 FIFNYVYHPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIFNYVYHPK 10 0 J3QQW9;Q15022 J3QQW9 SUZ12 Polycomb protein SUZ12 0 23392600.0 8732800.0 4313800.0 10346000.0 False True 8455582.04409305 6036322.836169824 7636072.226653 1.0 0.7138861410950076 0.9030806143011115 23.01147263599077 -10.210323515152826 4.819022511628687 1.000029973448697 0.8084833782833535 0.5773929788375094 0.0772383202533473 2.4877014888485792e-05 4.076573972343223e-06 0.07479737733931481 0.024928560668939365 6.161358582264937e-11 10.210323515152826 -0.19154659516534356 FIFNYVYHPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIFNYVYHPK 10 0 J3QQW9;Q15022 J3QQW9 SUZ12 Polycomb protein SUZ12 0 25242600.0 6907500.0 6307100.0 12028000.0 False True 9461389.418168629 6028431.467209401 9187234.124435822 1.0 0.6371613301988239 0.9710237807983731 23.173620630215705 -10.428180665545318 8.484945050624516 1.0000027554676276 0.8040925563544258 0.3146451052356263 0.1362987747073419 7.104656826126784e-06 4.788408600834953e-07 0.13197257716777505 0.04399024037916765 3.7309491884618194e-11 10.428180665545318 -0.19591019911320184 FIFNYVYHPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIFNYVYHPK 10 0 J3QQW9;Q15022 J3QQW9 SUZ12 Polycomb protein SUZ12 0 17559300.0 8732800.0 3154600.0 5671900.0 False True 7261710.128635629 3137605.5436609252 6857868.066097452 1.0 0.432075294673107 0.9443874713553111 22.791877911425047 -10.46623944816749 8.930368019452768 1.0000053352433638 0.6882313830142103 0.3305577229349007 0.20915057031433035 2.2217369950352502e-05 1.327676720655616e-06 0.20251263376472978 0.06750305630643208 3.417909441919988e-11 10.46623944816749 -0.3117739522291535 FIFNYVYHPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FIFNYVYHPK 10 0 J3QQW9;Q15022 J3QQW9 SUZ12 Polycomb protein SUZ12 0 52651000.0 11727000.0 22633000.0 18291000.0 False True 15180832.673729049 21373453.65399405 14962225.68150882 1.0 1.4079236701542428 0.9855998022691775 23.85574758943878 -6.654035674651891 1.9938307193510354 1.263845966827692 0.9873620598240247 0.2107198829423511 0.17393332939065062 0.4987013066222324 3.8044127061304476 0.07063264914005091 0.19273930487997948 2.2180142159308962e-07 6.654035674651891 -0.2764839070036673 FIGATANFSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIGATANFSR 10 0 E9PN81;Q8TDP1 E9PN81 RNASEH2C Ribonuclease H2 subunit C 0 5911300.0 2055600.0 2113800.0 1741900.0 False True 1709322.4785204518 2102412.5398435513 2106123.236364383 1.0 1.2299683449218715 1.2321392030059723 20.70499316895606 FIGATANFSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FIGATANFSR 10 0 E9PN81;Q8TDP1 E9PN81 RNASEH2C Ribonuclease H2 subunit C 0 24987100.0 3697400.0 12088000.0 9201700.0 False True 4786357.186650104 11415292.173794014 7527085.017415103 1.0 2.3849645416420326 1.5726124741398981 22.19049663276567 -10.252362914404456 5.59408496059967 0.9999356851519571 1.9787885078909702 0.6593604790683314 0.3316413428126315 0.000266054523031952 3.555739354611539e-05 0.3211312279937939 0.10703678313558428 5.592900403105064e-11 10.252362914404456 0.9788528227390131 FIGELFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIGELFK 7 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;A0A0A0MSA7;O43432;O43432-3;A0A0U1RQK7;O43432-4 Q04637-7 EIF4G1;EIF4G3 Eukaryotic translation initiation factor 4 gamma 1;Eukaryotic translation initiation factor 4 gamma 3 0 6520500.0 2093400.0 1627400.0 2799700.0 False True 2744467.6725144377 1384598.263555517 2510013.9006187506 1.0 0.5045052187796295 0.9145722231514266 21.388094915021128 -10.033009079160431 7.192582764712317 1.0000000322052007 0.7095387209655287 0.40082746582612405 0.1674091535104239 8.654714490364506e-08 1.1417712491405277e-08 0.16209323521011001 0.054031071962379364 9.268104477044293e-11 10.033009079160431 -0.290461311239672 FIGELFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIGELFK 7 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;A0A0A0MSA7;O43432;O43432-3;A0A0U1RQK7;O43432-4 Q04637-7 EIF4G1;EIF4G3 Eukaryotic translation initiation factor 4 gamma 1;Eukaryotic translation initiation factor 4 gamma 3 0 3860060.0 1698400.0 661660.0 1500000.0 False True 1644485.2216571583 925864.2885113182 1107105.000964576 1.0 0.5630116198784193 0.6732228337381707 20.649204612622007 -10.019283669191559 7.15042259701475 1.0000000371017033 0.618117226808303 0.9412054411953197 0.04499353964819131 2.6629385546400053e-08 3.6768787657219765e-09 0.0435648116556559 0.014521602478697247 9.565690626378638e-11 10.019283669191559 -0.3818828102934002 FIGELFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIGELFK 7 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;A0A0A0MSA7;O43432;O43432-3;A0A0U1RQK7;O43432-4 Q04637-7 EIF4G1;EIF4G3 Eukaryotic translation initiation factor 4 gamma 1;Eukaryotic translation initiation factor 4 gamma 3 0 8164300.0 2093400.0 2698200.0 3372700.0 False True 2867386.5520078475 2578984.602245789 2576137.722936875 1.0 0.8994199266366409 0.8984270785300889 21.45130497654402 FIGFCIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIGFCIQK 8 0 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 0 32844600.0 8855500.0 9632100.0 14357000.0 False True 11609646.256784001 8195028.225631728 12871475.362068592 1.0 0.7058809583317864 1.1086879890545547 23.468820678503008 -6.710915193170771 1.7916743280750504 0.8193562857731213 1.107779273746169 0.46959109294345525 0.12392202945517901 0.37322833149711954 2.335993931771569 0.05502644509043187 0.13965213865771278 1.945739998790316e-07 6.710915193170771 0.28842298797304766 FIGFCIQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FIGFCIQK 8 0 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 0 67809000.0 16512000.0 21574000.0 29723000.0 False True 25049911.188896544 17723951.141568642 23848236.021946326 1.0 0.7075454682420128 0.9520287653761078 24.57830215275914 -10.045879471254077 6.514788608924145 1.000000103537686 0.8297871173359794 0.39257237912209564 0.09980988810196621 1.5008544187457615e-07 2.1993918004437866e-08 0.09664056764351532 0.03221350286714462 8.997472516628573e-11 10.045879471254077 -0.17021298620170655 FIGFCIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIGFCIQK 8 0 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 0 28720200.0 8855500.0 8676700.0 11188000.0 False True 12129617.660889233 8293334.703990088 8545624.824092777 1.0 0.6837259784973384 0.7045254898385882 23.5320307400259 -10.431254288782979 5.959854547762653 1.0001247099848416 0.6941257341679635 0.9965439635772145 0.008491364947549368 1.4076415702095157e-05 1.3433020047375275e-06 0.008225056700432845 0.002740576252368955 3.704637437565795e-11 10.431254288782979 -0.30599897581687807 FIGFCIQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FIGFCIQK 8 0 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 0 64594000.0 16512000.0 25871000.0 22211000.0 False True 21375109.500180274 24431256.107563246 18168825.90410542 1.0 1.1429768866146486 0.849999196680241 24.34942847485159 -6.7740035087989545 1.5590310884610732 1.081589157077306 0.8480928461022451 0.7456407222730861 0.06032874821522749 0.26002133315858805 1.2477713232634202 0.030490865393246743 0.0723205949557921 1.6826604662831018e-07 6.7740035087989545 -0.23349631097506085 FIGGLSWDTTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIGGLSWDTTK 11 0 D6RF44 D6RF44 HNRNPD 0 130782000.0 35355000.0 35709000.0 59718000.0 False True 46350747.37830707 30381356.392591815 53538954.21550536 1.0 0.6554663756470689 1.1550828679962666 25.466089265851647 -6.721181746643698 1.755046517338161 0.7906472450747195 1.1543541759770564 0.5179947654677495 0.14496158763126274 0.3530781697641511 2.126048877168355 0.06556637054695055 0.1643687988770573 1.900282869609428e-07 6.721181746643698 0.36370693090233686 FIGGLSWDTTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIGGLSWDTTK 11 0 D6RF44 D6RF44 HNRNPD 0 74699000.0 0.0 18899000.0 55800000.0 False True 0.0 26445469.256982997 41184306.035882235 0.0 FIGGLSWDTTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIGGLSWDTTK 11 0 D6RF44 D6RF44 HNRNPD 0 119770000.0 35355000.0 33090000.0 51325000.0 False True 48426698.93295 31627974.386002924 39203092.071555465 1.0 0.6531102693948636 0.8095346768491234 25.529299327374538 -10.137001179427662 5.0952991512332915 1.0000107645075227 0.731322473121586 0.7973090666137432 0.06385999693144179 7.809284420383442e-06 1.3225893328677216e-06 0.061834652320563094 0.020610725383490843 7.294555292457526e-11 10.137001179427662 -0.26868829138593664 FIGGLSWDTTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIGGLSWDTTK 11 0 D6RF44 D6RF44 HNRNPD 0 38564800.0 0.0 9909800.0 28655000.0 False True 0.0 9856413.940458713 34646628.01424962 0.0 FIGGLSWDTTK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIGGLSWDTTKK 12 1 D6RF44 D6RF44 HNRNPD 1 5233700.0 2342200.0 1776000.0 1115500.0 True False 1947643.077053221 1766432.3354916002 1348745.8925107475 1.0 0.9069589578826773 0.6925015719776524 20.893297884246863 -6.957177857470349 0.4735363513525738 1.005474061045607 0.585142250446821 0.9996507770068125 0.0024061294150972243 0.0807251163626396 0.024976552397340535 0.002985285451666294 0.017696268700059754 1.1036265569944008e-07 6.957177857470349 -0.420331810598786 FIGGLSWDTTKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIGGLSWDTTKK 12 1 D6RF44 D6RF44 HNRNPD 0 18849900.0 1183800.0 7358300.0 10307800.0 False True 1551973.2639355077 6260470.322428755 9241247.735399479 1.0 4.033877688429631 5.9545147781511645 20.565672273550312 -8.323010847643577 0.28849003439607324 1.1758347592022912e-18 7.1417616417063465 0.9989909258375008 0.06479044684508009 0.1122589663534672 0.07243829771067106 0.6125986850981234 0.6194694087224661 4.753233533472965e-09 8.323010847643577 7.1417616417063465 FIGGLSWDTTKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIGGLSWDTTKK 12 1 D6RF44 D6RF44 HNRNPD 0 11299300.0 1183800.0 2297800.0 7817700.0 False True 1621482.8509921136 2196275.5981915267 5971320.270585468 1.0 1.3544858626458633 3.6826293086799415 20.628882335073204 -6.933954183354786 0.7135962840891583 0.9692561636291204 4.212549954901852 0.9972597799250094 0.06228698209847652 0.09063623601714829 0.06800074233036997 0.058145424710250415 0.20626914816379582 1.1642488473715753e-07 6.933954183354786 3.2432937912727313 up FIGGLSWDTTKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIGGLSWDTTKK 12 1 D6RF44 D6RF44 HNRNPD 0 11007900.0 4270900.0 2109200.0 4627800.0 False True 3551442.582950472 2097837.3209565803 5595451.5834703995 1.0 0.5907000527131531 1.5755433046651717 21.75997373042659 -6.793847892259333 1.481111276683397 0.7723835294023694 1.5871289437194314 0.8135020119292108 0.1744541477715406 0.22965972851178004 0.9951726318349046 0.09269587918597834 0.21641379639728736 1.6075041683225504e-07 6.793847892259333 0.8147454143170619 FIHVSHLNANIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIHVSHLNANIK 12 0 A0A3B3ISG8;Q16795 A0A3B3ISG8 NDUFA9 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial 0 7910300.0 3001900.0 1094600.0 3813800.0 False True 2906606.3276569843 1531679.4882635898 2814851.368452465 1.0 0.5269648915607629 0.9684322715699574 21.470904254628067 -10.551802199302772 9.278833138346501 1.0000175052003812 0.7476985815653602 0.303375072459958 0.1802283031843142 6.527016583202593e-05 3.1528948420962484e-06 0.1745173849370709 0.05816843472900585 2.8067116719612542e-11 10.551802199302772 -0.25231892363502106 FIHVSHLNANIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIHVSHLNANIK 12 0 A0A3B3ISG8;Q16795 A0A3B3ISG8 NDUFA9 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial 0 11529100.0 4927400.0 2402300.0 4199400.0 False True 6749192.937978151 2296158.442656238 3207588.2093578153 1.0 0.34021229853062934 0.4752550769897992 22.68628356571143 -9.870958160633863 6.699698040566577 1.0000000161539033 0.4077336877633126 0.9624717820973525 0.05513098344551685 1.3296157393909152e-08 2.255796344922054e-09 0.05338034677695444 0.01779344839536653 1.3459900187396343e-10 9.870958160633863 -0.5922663283905907 FIHVSHLNANIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIHVSHLNANIK 12 0 A0A3B3ISG8;Q16795 A0A3B3ISG8 NDUFA9 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial 0 7477700.0 3001900.0 2910900.0 1564900.0 False True 2496212.8567184964 2895218.403931585 1892113.3547199168 1.0 1.1598443602832886 0.7579935940267832 21.251309530062343 -6.798760285736135 1.4608860788412135 1.0883316951833117 0.7526090905379031 0.8285452452366512 0.06840201460913213 0.2225264372371158 0.9377068238623496 0.03683661396727104 0.0857370514640314 1.5894238088474087e-07 6.798760285736135 -0.3357226046454086 FIHVSHLNANIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FIHVSHLNANIK 12 0 A0A3B3ISG8;Q16795 A0A3B3ISG8 NDUFA9 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial 0 9564100.0 2492100.0 4890100.0 2181900.0 False True 3226072.57663513 4617961.636256621 1784816.5881845732 1.0 1.4314500143928144 0.5532475001062063 21.621347464350215 -6.77309656401089 1.562433459408261 1.2464837653688432 0.5476980744301178 0.7423389637324467 0.18199749113479374 0.2614421902476513 1.259951436033696 0.09178906768149482 0.21789631703769025 1.6861780673197402e-07 6.77309656401089 -0.6987856909387254 FIIDNTK(ub)GQMLGLGNPSFSDPFTGGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIIDNTKGQMLGLGNPSFSDPFTGGGR 27 1 Q9Y263;E5RIM3;H0YBW4 Q9Y263 PLAA Phospholipase A-2-activating protein 1 18004000.0 5144300.0 4286400.0 8573300.0 True False 4980997.012347454 5997981.873280698 6327695.536513052 1.0 1.2041729514015422 1.2703672619813364 22.24800311499181 -13.9998669662462 0.15743904840606415 3.602447135796173e-08 1.3373533632214996 0.9995420805636896 0.0024623490423589267 11.997968557998222 0.12534946259375057 3.664864671513761 0.0608761964596546 1.0003063684595975e-14 13.9998669662462 1.3373533271970282 FIIDNTK(ub)GQMLGLGNPSFSDPFTGGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FIIDNTKGQMLGLGNPSFSDPFTGGGR 27 1 Q9Y263;E5RIM3;H0YBW4 Q9Y263 PLAA Phospholipase A-2-activating protein 1 73256300.0 15855300.0 12351700.0 45049300.0 True False 13184384.45888564 12285158.940479508 54468900.345570944 1.0 0.9317961698393816 4.1313191765173025 23.652326881690627 -6.902029787710665 0.9483392511894302 0.8742824692456397 4.481366677512816 0.9875495828053873 0.16653011501990614 0.10992680242873391 0.16911005459637285 0.1311815130990535 0.3449253617518347 1.2530552265166044e-07 6.902029787710665 3.6070842082671764 up FIIPNVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIIPNVVK 8 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2 P00338 LDHA L-lactate dehydrogenase A chain 0 76235000.0 17511000.0 25794000.0 32930000.0 False True 22957090.576765217 21945635.744224515 29522719.486864813 1.0 0.9559415062131439 1.285995687830959 24.452436480596354 -6.873257168302713 1.1167737182767508 0.9745192616366427 1.3065560623481445 0.9678246995377464 0.026245061411525192 0.1337675278010661 0.3098424207822836 0.01820058141079783 0.04334982289426642 1.3388836301581567e-07 6.873257168302713 0.33203680071150177 FIIPNVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIIPNVVK 8 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2 P00338 LDHA L-lactate dehydrogenase A chain 0 76847000.0 27863000.0 11780000.0 37204000.0 False True 26978504.316435125 16483815.431888446 27459156.303924043 1.0 0.6109981205239245 1.0178161095163496 24.68530703195379 -10.989482002710727 12.161291961773566 1.1382448262143885 0.8144071150200953 0.21722038992304804 0.16608274853610416 0.06863263824974086 5.935860414121847e-05 0.017729082204167704 0.053602976597723805 1.0245142355977232e-11 10.989482002710727 -0.32383771119429317 FIIPNVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FIIPNVVK 8 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2 P00338 LDHA L-lactate dehydrogenase A chain 0 163223000.0 14096000.0 138770000.0 10357000.0 False True 21384662.555637415 114005409.2850412 8309934.410365639 1.0 5.331176444258978 0.3885931979868898 24.350073106256296 -6.675265791663456 1.9189907615958246 3.752095642863351 0.4082656461437791 0.3023397887776055 1.8376162036020227 0.44921666138022137 3.194133977114295 0.7696079007485436 2.041972463854011 2.112195963527794e-07 6.675265791663456 -3.343829996719572 FIIPNVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIIPNVVK 8 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2 P00338 LDHA L-lactate dehydrogenase A chain 0 99421000.0 17511000.0 32391000.0 49519000.0 False True 23985289.916981656 30959858.517286867 37823632.07581792 1.0 1.2907852531466462 1.5769512149627458 24.515646542119246 -6.971322239468907 0.22436906002556906 0.8751016285100062 2.000756836078425 0.9999909392671552 0.0007089822627852769 0.07587594617324145 0.007476312806029235 0.007667942467645813 0.02874219182992053 1.068261952029602e-07 6.971322239468907 1.125655207568419 FIIPNVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIIPNVVK 8 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2 P00338 LDHA L-lactate dehydrogenase A chain 0 45677900.0 27863000.0 7982600.0 9832300.0 False True 23169319.04019038 7939596.149377956 11888188.47058129 1.0 0.34267714711880964 0.5131004692006522 24.465712307388067 -10.628451770794625 9.968447139432136 1.000113167458088 0.42788880816107083 0.9376011529338281 0.06957502989508454 0.00017501987949780526 6.52349772451146e-06 0.06737860284604089 0.022455244341295477 2.3526007395456388e-11 10.628451770794625 -0.5722243592970173 FIIPNVVK(ub)YSPNCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FIIPNVVKYSPNCK 14 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2 P00338 LDHA L-lactate dehydrogenase A chain 1 84889000.0 46443000.0 12550000.0 25896000.0 True False 70457426.43810077 10310354.44640244 20777644.249380007 1.0 0.1463345309022951 0.29489644030120615 26.070248443432753 -10.115853089477895 5.944554384659576 1.0000043240651912 0.22061548855223273 0.9734724981188736 0.060650145540236906 3.475760402164435e-06 5.168374036131924e-07 0.05872457621793398 0.019574750301853853 7.658556321294507e-11 10.115853089477895 -0.7793888355129586 FIIPNVVK(ub)YSPNCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FIIPNVVKYSPNCK 14 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2 P00338 LDHA L-lactate dehydrogenase A chain 1 82265000.0 46443000.0 16755000.0 19067000.0 True False 60121379.02839575 15822569.521171302 15597001.643941188 1.0 0.2631770890301467 0.2594252143912836 25.841374765525202 FIIPQIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIIPQIVK 8 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 169835000.0 38183000.0 39026000.0 92626000.0 False True 50058282.76469798 33203472.92215656 83041950.05133139 1.0 0.6632962836186674 1.6589052892939846 25.577105464839303 -6.815465612410117 1.3912881762366822 0.8176398390308149 1.678611165242225 0.873640402604333 0.1469835424858093 0.19945037266521037 0.7597833002931607 0.08304153718143908 0.19167523481421356 1.5294468437636735e-07 6.815465612410117 0.8609713262114101 FIIPQIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIIPQIVK 8 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 117923000.0 54221000.0 18563000.0 45139000.0 False True 52499784.03407479 25975302.704766184 33315741.75902659 1.0 0.49476970586978053 0.63458816777995 25.645808152254865 -10.476074286679042 9.25062452546578 1.0000061968306546 0.5646789368248881 0.9281864846446286 0.057080648050113425 7.2952476057620025e-06 4.1309880461970584e-07 0.05526888618540759 0.018422699940734682 3.341378803854792e-11 10.476074286679042 -0.4353272600057665 FIIPQIVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FIIPQIVK 8 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 122260000.0 11390000.0 97584000.0 13286000.0 False True 17279462.72053846 80169372.77272797 10660016.276539337 1.0 4.6395755510058905 0.6169182716467675 24.042555023931357 -6.668454991632456 1.9429613775546624 3.326255930003724 0.6333572020435086 0.2721200697497289 1.5465759039619515 0.46471222052521816 3.380728927169495 0.6411704499338106 1.7164356962593768 2.145581462908007e-07 6.668454991632456 -2.6928987279602152 FIIPQIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIIPQIVK 8 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 130955000.0 38183000.0 38929000.0 53843000.0 False True 52300286.95677635 37208988.05901209 41126392.331393234 1.0 0.711449023019004 0.7863511793994974 25.640315526362194 -9.786692964134419 5.7711109082422665 1.0000000249871697 0.7489001012078373 0.9374395157341083 0.030578677299400222 9.850085677244202e-09 2.025867254593783e-09 0.02960767984794009 0.009869225660072105 1.6342068849748702e-10 9.786692964134419 -0.2510999237793323 FIIPQIVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIIPQIVK 8 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 90599000.0 54221000.0 17041000.0 19337000.0 False True 45087163.897576 16949196.750626344 23380277.295813832 1.0 0.3759206675569491 0.5185572849276248 25.42621342768914 -10.084213860328347 7.641329111677208 1.0000000555538475 0.44723897624328646 0.952435380742502 0.058231155199126514 5.511236510033892e-08 6.596956075995149e-09 0.05638207946021332 0.01879402452638637 8.237323832648462e-11 10.084213860328347 -0.5527610793105611 FIIPQIVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FIIPQIVK 8 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 44352000.0 11390000.0 17357000.0 15605000.0 False True 14744579.530465895 16391067.691970762 12765050.120821424 1.0 1.1116673526093315 0.8657452791004123 23.813681346023806 -6.783221174495391 1.5230364150183768 1.0629631854362411 0.8635864865808048 0.7787291618190688 0.047292659299895755 0.24559251805680868 1.1253624071928219 0.024450588571646822 0.05754665635261306 1.6473232404582716e-07 6.783221174495391 -0.1993766988554363 FIITALPTIYHCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIITALPTIYHCK 13 0 Q9H3N1 Q9H3N1 TMX1 Thioredoxin-related transmembrane protein 1 0 18073200.0 8431300.0 4256200.0 5385700.0 False True 11053515.948825354 3621191.5505376584 4828439.427282348 1.0 0.3276054033216896 0.4368238531193744 23.398002005332042 -10.109322253452246 5.497410432048333 1.000007841808687 0.38221462822449487 0.977095796667846 0.04458824541765773 4.285496296389446e-06 6.943098781345798e-07 0.04317293065849057 0.014390794328173714 7.774594496097226e-11 10.109322253452246 -0.6177932135841921 FIITALPTIYHCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIITALPTIYHCK 13 0 Q9H3N1 Q9H3N1 TMX1 Thioredoxin-related transmembrane protein 1 0 5817200.0 3014300.0 1505400.0 1297500.0 False True 2918612.6964443983 2106514.070557289 957645.8258343572 1.0 0.7217518354263144 0.3281167888432096 21.47685134542935 -6.9832431510826725 0.33954249883517457 1.043414774157562 3.8686409140395904e-14 0.9999365168308744 0.002196192191388342 0.07542859215136084 0.013428949412284653 0.005536746488090023 0.033216709849429905 1.0393381023825595e-07 6.9832431510826725 -1.0434147741575233 down FIITALPTIYHCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIITALPTIYHCK 13 0 Q9H3N1 Q9H3N1 TMX1 Thioredoxin-related transmembrane protein 1 0 18206300.0 8431300.0 4329900.0 5445100.0 False True 11548579.457315268 4138590.7009354536 4159079.525354628 1.0 0.35836361660168753 0.36013775899685424 23.461212066854934 -9.95782494563732 5.383718206910195 1.0000014401529107 0.3592506877974152 0.9999942497460502 0.0007242906112861482 1988287.2053128846 1.9948615161069578 38.697208900183135 0.00024794393946750215 1.1019834048215353e-10 9.95782494563732 -0.6407507523554955 FIK(ub)AVTHQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIKAVTHQVK 10 1 Q8WU90;F8WB26;F8WF67 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 1 6405300.0 1655700.0 4409400.0 340200.0 True False 1376787.9099466372 4385645.687002628 411334.24709292396 1.0 3.1854185058703854 0.2987636978224677 20.392874903063756 -6.704229294223013 1.815636716941986 2.3513921987793776 0.3065953050650178 0.43771285314577213 0.9217990510755407 0.38680292715678827 2.481781140977297 0.40457700963914334 1.0351258609740643 1.9759261360122802e-07 6.704229294223013 -2.0447968937143597 FIK(ub)FQEMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIKFQEMK 8 1 P33993;P33993-3;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 6167920.0 793020.0 1365800.0 4009100.0 True False 1039656.8996166035 1162027.9638467028 3594276.7900027293 1.0 1.1177033156565654 3.4571759119072825 19.987676067989455 -6.917349395904657 0.84414904625627 0.94328690707317 3.8123613001791066 0.9934124562334697 0.09184495537914504 0.09975665773637882 0.11388006621899247 0.07804257424761454 0.228166790700519 1.2096245823140428e-07 6.917349395904657 2.8690743931059366 up FIK(ub)FQEMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIKFQEMK 8 1 P33993;P33993-3;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 7902630.0 780830.0 2118600.0 5003200.0 True False 756042.9790547327 2964568.0283530485 3692711.82721731 1.0 3.9211633603946643 4.884261780771039 19.528108724632713 -9.326347439967996 0.3608757870127573 1.2464254737981657e-24 5.106954761493833 0.998238805384916 0.06930947827602642 0.706334172894253 0.1413331540700892 1.2170705223701541 0.2711005219078391 4.716855370906905e-10 9.326347439967996 5.106954761493833 FIK(ub)FQEMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIKFQEMK 8 1 P33993;P33993-3;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 5450620.0 793020.0 1117600.0 3540000.0 True False 1086220.924559693 1068220.7365910208 2703924.90858853 1.0 0.9834286123921165 2.489295545180723 20.050886129512346 -6.9044117322115985 0.932946847306937 0.9447421650513035 2.662327230309572 0.9886364872656814 0.07525933464215567 0.10823062611592142 0.15966783023813141 0.05996171224892789 0.15976488049140286 1.2462014946267682e-07 6.9044117322115985 1.7175850652582687 up FIK(ub)FQEMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIKFQEMK 8 1 P33993;P33993-3;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 7186030.0 780830.0 1754600.0 4650600.0 True False 649294.7416341326 1745147.6215391667 5623018.958055108 1.0 2.6877587475096636 8.660194819848996 19.30851400006699 -6.947691906163914 0.5836334059967353 0.9295382580806265 10.715671098930164 0.9990074837630332 0.10353190946150963 0.08442601210949319 0.039901686756749835 0.10805266286354415 0.4994152836881343 1.1279973875934191e-07 6.947691906163914 9.786132840849538 FIK(ub)GACPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIKGACPK 8 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WYT6 P52701 MSH6 DNA mismatch repair protein Msh6 1 3972800.0 1006200.0 1455200.0 1511400.0 True False 1319137.94405466 1238089.832325174 1355014.8263725336 1.0 0.9385597904337686 1.027197218061667 20.3311640063911 -6.720264100777534 1.7584540659684724 0.9626311459863885 1.0270603384093457 0.5137426119714922 0.02585338640338838 0.35479500576021394 2.1442216948331434 0.011673460725565936 0.029294677207890554 1.904302331897331e-07 6.720264100777534 0.0644291924229572 FIK(ub)GACPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIKGACPK 8 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WYT6 P52701 MSH6 DNA mismatch repair protein Msh6 1 4307900.0 1006200.0 1106100.0 2195600.0 True False 1378219.3315325757 1057228.8446164348 1677044.4998014066 1.0 0.7670976748242238 1.2168197480850442 20.39437406791399 -6.765957675212112 1.589977347483327 0.8657249811500046 1.2189690369362642 0.7148459762554467 0.09806202961891314 0.2730146835183197 1.3614628554315868 0.04863300323062466 0.11619897913108172 1.7141243518009772e-07 6.765957675212112 0.3532440557862596 FIK(ub)IDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIKIDGK 7 1 P62701;C9JEH7;P22090 P62701 RPS4X;RPS4Y1 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1 1 4269360.0 909160.0 1211300.0 2148900.0 True False 1191917.5643179652 1030578.761610419 1926552.4417043363 1.0 0.8646392942452636 1.616347052328859 20.18485302856193 -6.860304949058208 1.184070824323102 0.9264900182326593 1.6529821981517534 0.9540181422292467 0.0701529907014512 0.1464945126357827 0.39008534997753147 0.04620149518534539 0.10789419240236753 1.3794153388043858e-07 6.860304949058208 0.7264921799190941 FIK(ub)IDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIKIDGK 7 1 P62701;C9JEH7;P22090 P62701 RPS4X;RPS4Y1 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1 1 5644180.0 859580.0 1244500.0 3540100.0 True False 832293.1034103038 1741435.3399817662 2612841.609276462 1.0 2.092334218373636 3.1393286794885085 19.666732157094053 -6.971641312329159 0.21540697724986105 0.48827429908115766 4.772796519744373 0.999992510799352 0.0023902914794054733 0.07577364120906234 0.0070925941896923935 0.030047722263142253 0.10717695495648275 1.0674773963187032e-07 6.971641312329159 4.284522220663216 FIK(ub)IDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIKIDGK 7 1 P62701;C9JEH7;P22090 P62701 RPS4X;RPS4Y1 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1 1 4029020.0 909160.0 739660.0 2380200.0 True False 1245301.0211251825 706979.3754714692 1818045.7817577438 1.0 0.5677176549913074 1.4599247498529007 20.24806309008482 -6.7749354040034095 1.55549172949234 0.7536326909695752 1.4659197515745346 0.7491619891932195 0.18245517632666394 0.2584897379380955 1.2349052109775496 0.09242068978280475 0.219025306888369 1.6790537382742336e-07 6.7749354040034095 0.7122870606049594 FIK(ub)IDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIKIDGK 7 1 P62701;C9JEH7;P22090 P62701 RPS4X;RPS4Y1 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1 1 3966280.0 859580.0 1772100.0 1334600.0 True False 714778.8558506564 1762553.34556569 1613658.6895068074 1.0 2.465872250051493 2.2575635475204376 19.44713743252833 -10.212930126708144 4.949571609382839 0.9998268477170911 2.3617178987877545 0.9827517270189717 0.08504167170324331 0.00016251123227846844 2.5841964906438684e-05 0.08235138575025001 0.027447081519140146 6.12448920215428e-11 10.212930126708144 1.3618910510706634 FIK(ub)IDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FIKIDGK 7 1 P62701;C9JEH7;P22090 P62701 RPS4X;RPS4Y1 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1 1 6489890.0 920990.0 1909900.0 3659000.0 True False 1192239.7104270237 1803612.3860629704 2993099.5445104516 1.0 1.5127934175393065 2.5104846939198286 20.18524290099336 -6.960580568810435 0.42717253108851666 0.9591609981544246 3.1021989700665302 0.9997911298904826 0.009063852976037071 0.07949437342620728 0.020369791916355778 0.012976042774227346 0.08289509224004497 1.0950133934243202e-07 6.960580568810435 2.1430379719121055 FIKPLSNAYHELAQVYSTNNPSELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIKPLSNAYHELAQVYSTNNPSELR 25 1 Q9UNS2;Q9UNS2-2 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 0 26268800.0 10679000.0 4269800.0 11320000.0 False True 10340000.990389073 5974753.406712846 8354952.40727932 1.0 0.5778290942395768 0.8080223991317954 23.30173298804904 -10.085966691069059 5.17397244241133 1.000005728755044 0.6929257466851069 0.7035003667280987 0.09397602320049546 6.210288230519735e-06 1.097018951993617e-06 0.09099359035320335 0.030330631066236152 8.204144649561955e-11 10.085966691069059 -0.30707998206993703 FIKPLSNAYHELAQVYSTNNPSELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIKPLSNAYHELAQVYSTNNPSELR 25 1 Q9UNS2;Q9UNS2-2 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 0 22131400.0 10679000.0 4848100.0 6604300.0 False True 8880061.659914335 4821982.3230274925 7985228.59516694 1.0 0.5430122568624157 0.8992312104332812 23.082138263483316 -9.832333952912578 6.324345547518841 1.0000000114998213 0.7211217336477668 0.4497060709150269 0.14542577882642585 2.358049079902613e-08 4.478838048058234e-09 0.14080791012136717 0.04693596829195597 1.4711807955465656e-10 9.832333952912578 -0.27887827785205455 FIKWYNAWNEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIKWYNAWNEKR 12 2 A0A0C4DGC1;O95715 A0A0C4DGC1 CXCL14 C-X-C motif chemokine 14 1 7372000.0 1501000.0 3311900.0 2559100.0 True False 1248148.0055746224 3294058.1373393238 3094195.9780584993 1.0 2.6391566726277826 2.4790297017972587 20.251357588658955 -10.151307826796035 4.458644002930061 0.9997444177300776 2.559093187262006 0.992150828884283 0.0653715622631844 17603570.38741094 11597725.447817657 49492.92087071248 0.025840379066201416 7.058170956055833e-11 10.151307826796035 1.5593487695319286 FILLACDGLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FILLACDGLFK 11 0 Q9H0C8;H7C2I8;F8SNU7 Q9H0C8 ILKAP;ILKAP3 Integrin-linked kinase-associated serine/threonine phosphatase 2C 0 4825350.0 668550.0 1762600.0 2394200.0 False True 915731.0018844197 1684722.503861249 1828739.270096796 1.0 1.83975698146549 1.99702671017314 19.804564339962297 -10.953405943462618 0.31686764192011013 2.708110259853352e-14 2.036337400230273 0.9992630790755769 0.011881088593470663 2.7785771754720114 0.16009396346868793 2.0959190608500777 0.05280087726576935 1.1132534675402716e-11 10.953405943462618 2.036337400230246 FILNLPTFSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FILNLPTFSVR 11 0 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 42233400.0 11265000.0 21961000.0 9007400.0 False True 14768524.090415176 18684504.403307546 8075400.653081875 1.0 1.2651571876050807 0.5467980824382336 23.81602232011575 -6.806753233443581 1.4279246272641748 1.1450715648934895 0.5351163881671254 0.8512480763209938 0.11439350461488511 0.21125154033719035 0.8494939663217702 0.06300071404957214 0.1459739117766957 1.5604388939099585e-07 6.806753233443581 -0.6099551767263641 FILNLPTFSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FILNLPTFSVR 11 0 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 202237000.0 67520000.0 68188000.0 66529000.0 False True 65376614.55857948 95415823.99572235 49103059.072781496 1.0 1.459479427620511 0.7510798686093424 25.96227133519854 -6.7316219211449395 1.7172968697857278 1.2760092658563191 0.7513726104366094 0.5667973228444259 0.1931304033665455 0.33319620655818105 1.9257904409334132 0.08909472353221765 0.220679346668563 1.855145934135554e-07 6.7316219211449395 -0.5246366554197097 FILNLPTFSVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FILNLPTFSVR 11 0 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 1005680000.0 311410000.0 319860000.0 374410000.0 False True 472431737.12053454 262778483.92241314 300407699.3902674 1.0 0.5562252983341989 0.6358753567684688 28.81553064476629 -10.798087065593478 7.175306816193045 1.014372754443652 0.5960503275513338 0.9716667562166391 0.03251700019113751 0.007329308619871226 0.00020624630502822096 0.030865001587782458 0.010494816684074915 1.5918895595074473e-11 10.798087065593478 -0.41832242689231824 FILNLPTFSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FILNLPTFSVR 11 0 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 138849000.0 11265000.0 30638000.0 96946000.0 False True 15429974.925178366 29284311.85368265 74049351.46554331 1.0 1.8978846041996489 4.799058444658317 23.87923238163864 -6.9497712231830615 0.5613489833614542 0.9623210581516004 5.873595325009991 0.9991832122235138 0.046334304584853714 0.08357772499729937 0.03634346072658956 0.04958719421025203 0.24123750926620177 1.1226096647430453e-07 6.9497712231830615 4.911274266858391 FILNLPTFSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FILNLPTFSVR 11 0 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 188869000.0 67520000.0 64846000.0 56503000.0 False True 56145871.64317033 64496661.72707685 68317516.05964565 1.0 1.1487338220872083 1.2167860977175853 25.742676610632817 -13.999999999999497 0.10511554039582723 0.27522522550813394 1.350885670893614 0.9997678862001101 0.0013791252430429622 12.043750041406176 0.09755033571792335 1.870866978973297 0.11930112873527982 1.0000000000011576e-14 13.999999999999497 1.0756604453854801 FILNLPTFSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FILNLPTFSVR 11 0 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 811520000.0 311410000.0 340580000.0 159530000.0 False True 403126383.80881387 321626423.60611874 130497176.9160296 1.0 0.7978302500752539 0.32371281602327223 28.58665696685874 -6.956816870832308 0.4781875733112782 1.0115765422806 0.0902597369485924 0.9996333202333259 0.005427482363947412 0.08085840704549195 0.025486104013896668 0.006660537852197838 0.03911340330206926 1.1045442754462149e-07 6.956816870832308 -0.9213168053320075 down FILSIAYSPDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FILSIAYSPDGK 12 0 H0YN81;Q9GZS3;H0YMF9;H0YL19;H3BQA8 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 0 54290000.0 29216000.0 11002000.0 14072000.0 False True 28288554.072029855 15395155.974672046 10386121.049049009 1.0 0.5442185533934347 0.3671492372004346 24.753715101588213 -13.999999999999687 0.1308041531596919 3.166262953823203 0.12168982332926387 0.9996419910847743 0.005044014607944566 11.935565416706464 0.11254904504166194 6.642709566173925 0.21836177755124453 1.0000000000007199e-14 13.999999999999687 -3.0445731304939394 FILSIAYSPDGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FILSIAYSPDGK 12 0 H0YN81;Q9GZS3;H0YMF9;H0YL19;H3BQA8 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 0 400540000.0 123190000.0 141270000.0 136080000.0 False True 186888236.39535886 116059264.75245206 109183728.35401721 1.0 0.6210089355593825 0.5842193733533924 27.47760052118254 -13.999999999999998 0.32979477145120895 5.120472957086294 0.5776883036094131 0.999714415234449 0.0031758817576940613 18.80588425619274 0.18362745689866158 53.74260801436624 0.011798290125541126 1.0000000000000041e-14 13.999999999999998 -4.542784653476881 FILSIAYSPDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FILSIAYSPDGK 12 0 H0YN81;Q9GZS3;H0YMF9;H0YL19;H3BQA8 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 0 14462600.0 2476500.0 3827300.0 8158800.0 False True 3392128.97489607 3658197.230811394 6231859.475760485 1.0 1.0784369515087426 1.837152868266579 21.693759594150265 -6.926743788100046 0.7730481857792351 0.9869631629800906 1.9807410996016053 0.9958587727188243 0.02429368947032452 0.0943640699130956 0.08622273065677395 0.021718214974684357 0.06992002866596066 1.1837396966515731e-07 6.926743788100046 0.9937779366215147 FILSIAYSPDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FILSIAYSPDGK 12 0 H0YN81;Q9GZS3;H0YMF9;H0YL19;H3BQA8 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 0 51300300.0 29216000.0 8727300.0 13357000.0 False True 24294398.48825329 8680284.302666588 16149886.944209823 1.0 0.3572957077683416 0.6647576375277839 24.53412037702249 -10.52295433585759 6.365413037191414 1.0004494614824568 0.5110266726481708 0.7712874943143389 0.12552080720701267 0.0008013397287765464 6.005495271445098e-05 0.12164141005758435 0.04051166632627267 2.999477884230367e-11 10.52295433585759 -0.489422788834286 FILSIAYSPDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FILSIAYSPDGK 12 0 H0YN81;Q9GZS3;H0YMF9;H0YL19;H3BQA8 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 0 325390000.0 123190000.0 100340000.0 101860000.0 False True 159471883.43793657 94755990.79405113 83322525.17185976 1.0 0.5941861897613341 0.5224903812231408 27.24872684327499 -13.999999999999998 0.24383473110192752 3.7368825240439563 0.49192341600922124 0.9995314929824348 0.00455083387632 13.761923167093666 0.15627041286164584 18.381025306073287 0.0342609512276149 1.0000000000000041e-14 13.999999999999998 -3.244959108034735 FILSLASCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FILSLASCK 9 0 A0A087WV29;Q9H0A0-2;Q9H0A0;E9PMU0 A0A087WV29 NAT10 N-acetyltransferase 10 0 11093800.0 2815000.0 4102300.0 4176500.0 False True 3690492.260498776 3490252.8306401568 3744355.8438169155 1.0 0.9457418101097558 1.0145952299899579 21.81538183396055 -6.696637590621936 1.8432569372395338 0.9661967841461825 1.0143753979399637 0.40148796322820945 0.022917503009807653 0.40254088886109823 2.6566270355161095 0.009928814443865296 0.025637035606848022 2.0107700569424942e-07 6.696637590621936 0.04817861379378119 FILSLASCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FILSLASCK 9 0 A0A087WV29;Q9H0A0-2;Q9H0A0;E9PMU0 A0A087WV29 NAT10 N-acetyltransferase 10 0 12426400.0 2815000.0 3934400.0 5677000.0 False True 3855781.572514611 3760565.198679057 4336209.52148505 1.0 0.9753055581482389 1.1245993684899325 21.878591895483442 -6.864414607217507 1.1631481134854147 0.9864082459488481 1.1324657163814658 0.9587885595247599 0.01326434587149742 0.14232752998023765 0.3634096854996118 0.008876698877473851 0.020836234243233196 1.366423721178456e-07 6.864414607217507 0.14605747043261763 FILSLASCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FILSLASCK 9 0 A0A087WV29;Q9H0A0-2;Q9H0A0;E9PMU0 A0A087WV29 NAT10 N-acetyltransferase 10 0 12240700.0 3488800.0 5023600.0 3728300.0 False True 4516320.374529366 4744032.243900691 3049787.6555885035 1.0 1.0504197777145192 0.6752815129742238 22.106716399622577 -6.8730073408298304 1.118125704615589 1.0291031368924513 0.6520244361229754 0.9675905464529103 0.02992704290921966 0.13400095221474564 0.3112940182851557 0.020732567102458556 0.049355887333264264 1.3396540432158745e-07 6.8730073408298304 -0.3770787007694758 FIMESGAK(ub)GCEVVVSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FIMESGAKGCEVVVSGK 17 1 P23396;P23396-2;E9PL09;H0YEU2 P23396 RPS3 40S ribosomal protein S3 1 120886000.0 13534000.0 25638000.0 81714000.0 True False 20532067.46793396 21062698.58939169 65563192.08348146 1.0 1.0258440180116515 3.1932094605609027 24.29137557054545 -6.909503131541118 0.8991093941242605 0.9318349844200345 3.4703507851653894 0.9907327690833805 0.09894762432907857 0.1047475610200184 0.1405553489302035 0.08081125412605045 0.2223157895356993 1.231677104524265e-07 6.909503131541118 2.5385158007453548 up FIMESGAK(ub)GCEVVVSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIMESGAKGCEVVVSGK 17 1 P23396;P23396-2;E9PL09;H0YEU2 P23396 RPS3 40S ribosomal protein S3 1 19368200.0 0.0 1789200.0 17579000.0 True False 0.0 1779561.2244716054 21254687.623887453 0.0 FIMESGAK(ub)GCEVVVSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FIMESGAKGCEVVVSGK 17 1 P23396;P23396-2;E9PL09;H0YEU2 P23396 RPS3 40S ribosomal protein S3 1 123339000.0 13534000.0 21517000.0 88288000.0 True False 17520029.7950242 20319560.03503689 72220489.91137983 1.0 1.15979026706951 4.122167071421928 24.0625018926379 -6.918046187743335 0.8390945074111298 0.9299216179314396 4.579042442240902 0.9936206644956386 0.11466432392888316 0.09933502298795963 0.11167335786002117 0.09778625994069677 0.28766019845574126 1.207685389475124e-07 6.918046187743335 3.6491208243094624 up FINLNGLQHEGIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FINLNGLQHEGIFR 14 0 E7EQN5;P98171;P98171-2;E9PCM6 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 0 12095120.0 1736500.0 8800720.0 1557900.0 False True 2276568.3162899194 7487686.880937879 1396703.4524320303 1.0 3.289023583153622 0.6135126463976323 21.11842932237505 -6.680228279986319 1.9014711405311935 2.4480483698013513 0.6237822954859977 0.324965565109828 0.970103099308285 0.4380333040587338 3.0623333749391706 0.4093855775711527 1.0792551497256397 2.088198214152692e-07 6.680228279986319 -1.8242660743153536 FINLNGLQHEGIFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FINLNGLQHEGIFR 14 0 E7EQN5;P98171;P98171-2;E9PCM6 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 0 14159900.0 7801100.0 2665200.0 3693600.0 False True 7553458.350606256 3729428.2588343886 2726135.354375168 1.0 0.4937378463912569 0.3609122110478524 22.848705902888934 -13.999999999999998 0.18783307035639057 3.693865282684702 0.2635159742816164 0.9994907467907861 0.006213806215129033 12.31622556189288 0.1374349500395382 12.134652612324098 0.09294490943534471 1.0000000000000041e-14 13.999999999999998 -3.430349308403086 FINLNGLQHEGIFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FINLNGLQHEGIFR 14 0 E7EQN5;P98171;P98171-2;E9PCM6 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 0 10762700.0 3765800.0 4839800.0 2157100.0 False True 5712993.916857231 3976099.8764700033 1730748.239509482 1.0 0.695974813615291 0.3029494280402773 22.445815563078597 -7.129697352919913 0.3379958324867992 1.0488670378003038 6.695578375669303e-14 0.9999073389035098 0.0027467127175181375 0.07960767880239836 0.016075963446359767 0.007241542740046735 0.03623810243596279 7.418270186969532e-08 7.129697352919913 -1.0488670378002367 down FINLNGLQHEGIFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FINLNGLQHEGIFR 14 0 E7EQN5;P98171;P98171-2;E9PCM6 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 0 15932600.0 1736500.0 7541000.0 6655100.0 False True 2378530.9771479997 7207813.685247751 5083302.446086871 1.0 3.030363596058921 2.137160497351207 21.18163938389794 -10.034856990168798 4.7086042382322315 0.9999570064033133 2.5837620467047966 0.807394877561747 0.36464863825623683 126094915.9585354 0.9883878163085688 61804.25459864651 0.12482892793447099 9.228752728512577e-11 10.034856990168798 1.5838050403014834 FINLNGLQHEGIFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FINLNGLQHEGIFR 14 0 E7EQN5;P98171;P98171-2;E9PCM6 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 0 13792900.0 7801100.0 3052300.0 2939500.0 False True 6486960.297327252 3035856.65406589 3554135.85928762 1.0 0.46799371584202837 0.547889257276939 22.62911117832321 -10.706612684235152 6.821587203436204 1.0049051194332825 0.5079414865595993 0.9806103776706694 0.03261721820648702 0.002442974204290155 0.00010506886184041 0.03170791079597681 0.010527161909444792 1.9651120365535874e-11 10.706612684235152 -0.4969636328736833 FINNNAVTK(ub)MAQSSSK ddPTM_RPMI8226_Bortezomib_1h_R1 2 FINNNAVTKMAQSSSK 16 1 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21;A0A590UJ56 A0A590UJC4 CUL1 Cullin-1 1 88292380.0 20828800.0 37465280.0 29998300.0 True False 27306758.506386124 31875606.262517646 26894363.680012662 1.0 1.1673156392789361 0.9848977011944857 24.702754730994492 -6.665498866767686 1.9535513940505893 1.1072071155816468 0.9856506292573758 0.2592324245510118 0.07114648108708999 0.47149629260762216 3.464655738855685 0.02936674953392706 0.07891764724087268 2.1602356716082188e-07 6.665498866767686 -0.12155648632427096 FINNNAVTK(ub)MAQSSSK ddPTM_RPMI8226_Bortezomib_2h_R1 2 FINNNAVTKMAQSSSK 16 1 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21;A0A590UJ56 A0A590UJC4 CUL1 Cullin-1 1 150202410.0 38433700.0 48903310.0 62865400.0 True False 37213643.231043756 68430656.7103927 46399065.818425626 1.0 1.8388593743841666 1.2468294364610708 25.149328302029843 -9.807935916911829 5.6531575288047815 0.9999999009789973 1.5428444054263941 0.5285222835503178 0.24169521007386766 163375696.28518063 5.770169834800338e-05 210.4874214282658 0.08273869912194623 1.5561952417976993e-10 9.807935916911829 0.5428445044473968 FINNNAVTK(ub)MAQSSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FINNNAVTKMAQSSSK 16 1 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21;A0A590UJ56 A0A590UJC4 CUL1 Cullin-1 1 92690000.0 31514000.0 21967000.0 39209000.0 True False 47809041.982006155 18046817.221045602 31459323.96408482 1.0 0.37747707280639226 0.6580203798253296 25.510780160847645 -10.4402034044871 6.116546322102371 1.0001816567650261 0.5177487263159049 0.7975669304334451 0.11453132549156005 0.0002838211127023185 2.5975712854415292e-05 0.11093552169897303 0.03696482635398937 3.6290804474963305e-11 10.4402034044871 -0.4824329304491213 FINNNAVTK(ub)MAQSSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FINNNAVTKMAQSSSK 16 1 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21;A0A590UJ56 A0A590UJC4 CUL1 Cullin-1 1 93302180.0 20828800.0 35347200.0 37126180.0 True False 28529770.237155367 33785443.82644075 28357740.92167832 1.0 1.1842171719434575 0.9939701822325576 24.765964792517384 -6.653532438429552 1.99608155994228 1.119205578637782 0.9947724210013795 0.20840805103785986 0.07855856441025359 0.49995356312787625 3.822177491755759 0.031875515316631575 0.0870242835578622 2.2205858167179793e-07 6.653532438429552 -0.12443315763640239 FINNNAVTK(ub)MAQSSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FINNNAVTKMAQSSSK 16 1 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21;A0A590UJ56 A0A590UJC4 CUL1 Cullin-1 1 140109500.0 38433700.0 75442200.0 26233600.0 True False 31959324.451601215 75035777.89449583 31718924.46953829 1.0 2.347852440001635 0.9924779391871382 24.92973357746412 -6.647482322424331 2.0177631789262156 1.8763785334914913 0.9981985637058182 0.18379412205647405 0.5756402558656435 0.5147414599290883 4.014134605279305 0.23161407643562495 0.637435426210954 2.2517370698601652e-07 6.647482322424331 -0.8781799697856731 FINNNAVTK(ub)MAQSSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FINNNAVTKMAQSSSK 16 1 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21;A0A590UJ56 A0A590UJC4 CUL1 Cullin-1 1 72496000.0 31514000.0 25394000.0 15588000.0 True False 40795494.23381063 23980801.576879956 12751143.946386702 1.0 0.5878296617621331 0.3125625558868402 25.281906482940094 -8.27488974765877 0.2086019859347111 1.2695141788859363 5.200403206835969e-10 0.9997290960724298 0.004649612991870174 0.09189972275683865 0.04590852487329714 0.11186891651658143 0.11512125526967973 5.3101923452996e-09 8.27488974765877 -1.269514178365896 down FINPDWIALHTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FINPDWIALHTSR 13 0 A0A3B3IS62;A0A3B3ITD6;A0A3B3ITI5;S4R350;Q9Y672 A0A3B3IS62 ALG6 Dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase 0 4535700.0 1558900.0 1444000.0 1532800.0 False True 2043732.9964090742 1228560.8286679157 1374200.559655826 1.0 0.6011356820223333 0.672397305357576 20.96277529695099 -10.745245664366047 6.939177799176305 1.0062001223672474 0.6367664936900316 0.9719429710343926 0.02909243590229259 0.0028106091544030064 0.00010318425664588971 0.02837108467042108 0.009389543312515495 1.7978536479599707e-11 10.745245664366047 -0.36943362867721585 FINQLLGVVPLSTPTEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FINQLLGVVPLSTPTEDK 18 0 Q14CX7-2;Q14CX7 Q14CX7-2 NAA25 N-alpha-acetyltransferase 25, NatB auxiliary subunit 0 3562880.0 439100.0 765280.0 2358500.0 False True 601447.1362313206 731467.3991574586 1801470.8748322146 1.0 1.2161790373478998 2.995227288170771 19.19807841275503 -6.92957335575106 0.7502874561049748 0.9725135569171576 3.356518196445905 0.9964537053449241 0.05323674086353144 0.09285995864887628 0.07877029781865061 0.04837871308889936 0.16135248937329408 1.1760523234275949e-07 6.92957335575106 2.3840046395287477 up FINWFSHHLSNFQFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FINWFSHHLSNFQFR 15 0 Q09161 Q09161 NCBP1 Nuclear cap-binding protein subunit 1 0 66928000.0 13736000.0 29163000.0 24029000.0 False True 20838516.236112054 23958634.79844102 19279657.61771516 1.0 1.1497284416498887 0.9251933966538619 24.312749221338017 -6.726940157985332 1.7341150307720143 1.0904098149260202 0.9253930757234604 0.5451474200191782 0.06295886660197283 0.3420030176639861 2.013337165266648 0.028786407036992936 0.07168771423895345 1.8752528838566947e-07 6.726940157985332 -0.16501673920255977 FINWFSHHLSNFQFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FINWFSHHLSNFQFR 15 0 Q09161 Q09161 NCBP1 Nuclear cap-binding protein subunit 1 0 72605000.0 13736000.0 24319000.0 34550000.0 False True 17781522.77703947 22965626.271880932 28262254.51293694 1.0 1.291544405945675 1.5894169957946909 24.083875543430466 -6.970857090358427 0.23682211310593632 0.8887372499637048 2.0008060139789103 0.9999883169001844 0.0008224769138577309 0.07602557057796777 0.008028306592328312 0.00728333713325174 0.029206607146488494 1.0694067220285525e-07 6.970857090358427 1.1120687640152056 FINYVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FINYVK 6 0 P06748-2;P06748 P06748-2 NPM1 Nucleophosmin 0 44533300.0 8224300.0 22096000.0 14213000.0 False True 10782136.944234485 18799362.929533396 12742375.10072304 1.0 1.743565586929959 1.1818042347845295 23.362139802721167 -10.391717102841492 5.534956113817684 0.999801177195316 1.4626849108572473 0.47492615068431965 0.22933811166205068 0.0005629142817688907 6.186335708944631e-05 0.2221496501003833 0.07401855725981332 4.057727676420259e-11 10.391717102841492 0.46288373366193125 FINYVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FINYVK 6 0 P06748-2;P06748 P06748-2 NPM1 Nucleophosmin 0 29765700.0 13765000.0 4444700.0 11556000.0 False True 13328037.609580062 6219491.888804296 8529136.927431079 1.0 0.46664723427354277 0.6399394402444077 23.667961041086915 -10.632915413911851 7.003507963831695 1.0011998932440276 0.5532933372589759 0.8985784034156317 0.07074624683831726 0.0013285125393627908 6.963317231576942e-05 0.06865800562961963 0.02283325298429016 2.3285447363964203e-11 10.632915413911851 -0.4479065559850517 FINYVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FINYVK 6 0 P06748-2;P06748 P06748-2 NPM1 Nucleophosmin 0 145617700.0 9939800.0 128150000.0 7527900.0 False True 15079403.296717148 105280631.25947993 6040007.265404215 1.0 6.981750483614957 0.40054683508061295 23.846076005424262 -6.667432098744409 1.946313162397753 4.82646309783031 0.4273189684210453 0.2678050046735403 2.5424186563187425 0.4670315024201521 3.408246354708135 1.0525135843953735 2.8216695228697373 2.1506409023603506e-07 6.667432098744409 -4.399144129409264 FINYVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FINYVK 6 0 P06748-2;P06748 P06748-2 NPM1 Nucleophosmin 0 33309300.0 8224300.0 12835000.0 12250000.0 False True 11265045.963350587 12267907.26033084 9356802.29666934 1.0 1.0890241637932891 0.8306048929680822 23.42534986424406 -6.813676517006435 1.3988637395828163 1.0483109094111676 0.8256863120187271 0.8692553130583849 0.038757176857369395 0.20182338531785463 0.7776225771624841 0.021780444708720554 0.050307843338234154 1.5357604636437637e-07 6.813676517006435 -0.22262459739244045 FINYVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FINYVK 6 0 P06748-2;P06748 P06748-2 NPM1 Nucleophosmin 0 20799300.0 13765000.0 5176400.0 1857900.0 False True 11446207.392894534 5148513.705765052 2246378.300040986 1.0 0.4498008404915934 0.196255250576315 23.44836631652119 -9.605114886647318 0.21948396158960248 1.493417335865373 6.641358256512202e-17 0.9993243751492787 0.008720438955372245 1.0272961483410188 0.09010192517240621 0.4616257377136134 0.12911899390958093 2.4824763133739077e-10 9.605114886647318 -1.493417335865373 FINYVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FINYVK 6 0 P06748-2;P06748 P06748-2 NPM1 Nucleophosmin 0 33521800.0 9939800.0 10786000.0 12796000.0 False True 12867267.04275022 10185749.61834398 10467259.298047494 1.0 0.7916016341700871 0.8134796039649338 23.61720232751671 -10.16211390412308 5.074011367280848 1.0000110671086748 0.8025406190672623 0.9908769581104381 0.008931643768428855 1.1182587385027638e-06 1.8465828154649954e-07 0.008648511430428562 0.0028826756306581432 6.88471704479397e-11 10.16211390412308 -0.19747044804141256 FIPTSIFVKPQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIPTSIFVKPQGR 13 1 Q7Z392;D6RHE5 Q7Z392 TRAPPC11 Trafficking protein particle complex subunit 11 0 7110500.0 1973700.0 1740800.0 3396000.0 False True 2587539.8133379915 1481079.4255852518 3044614.4967322517 1.0 0.5723890384027066 1.176644502642308 21.303149630221505 -6.716609228792612 1.7717253656745273 0.738910224377523 1.1755167805034643 0.4964255731589132 0.18001844767539824 0.3619211726006498 2.218410003863955 0.08073962984954294 0.20348347368909975 1.9203959049425814e-07 6.716609228792612 0.43660655612594135 FIPTSIFVKPQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIPTSIFVKPQGR 13 1 Q7Z392;D6RHE5 Q7Z392 TRAPPC11 Trafficking protein particle complex subunit 11 0 5345200.0 1973700.0 1684700.0 1686800.0 False True 2703430.2272369806 1610264.383442104 1288412.580736479 1.0 0.5956374857463446 0.4765843659495111 21.366359691744396 -13.999999999999998 0.17140341460338557 3.0468118348089144 0.37311965886124165 0.9995110705042257 0.00495337204463277 12.105459543351273 0.1311298679231847 8.239513892172884 0.0958360010724971 1.0000000000000041e-14 13.999999999999998 -2.673692175947673 FIQSSGQPVPLVVESCIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIQSSGQPVPLVVESCIR 18 0 E7EQN5;P98171;P98171-2;A0A0B4J1X7;E9PCM6;H7C2Z8 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 0 3308700.0 1111500.0 2197200.0 0.0 False True 1457187.2637813112 1869386.3246185195 0.0 1.0 1.2828730878195964 0.0 20.47475486001995 -6.887997010265152 1.3231363949395087 1.1473978108529574 2.330644643711453e-20 0.937473374629315 0.1376121193750964 0.14286976489084618 0.5025605913960447 0.0845971690083 0.17084079548501746 1.294204750878697e-07 6.887997010265152 -1.1473978108529574 down FIQSSGQPVPLVVESCIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIQSSGQPVPLVVESCIR 18 0 E7EQN5;P98171;P98171-2;A0A0B4J1X7;E9PCM6;H7C2Z8 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 0 3816300.0 1111500.0 1293400.0 1411400.0 False True 1522451.5871580788 1236253.3112981638 1078056.3886954375 1.0 0.8120148592743406 0.7081055304410813 20.53796492154284 -13.99999999965233 0.07090936704243408 2.0800411358755335 0.33795617496079816 0.9999212955221308 0.0010716852906932127 12.350822199719616 0.07217351090180311 2.194545636610034 0.3404529446851061 1.0000000008005405e-14 13.99999999965233 -1.7420849609147353 FISDIANDALQHCK(ub)MK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FISDIANDALQHCKMK 16 1 Q12962;A0A087WWP5 Q12962 TAF10 Transcription initiation factor TFIID subunit 10 1 5250900.0 1634700.0 1847200.0 1769000.0 True False 1582807.3432895397 2584796.5930207428 1305645.8311375561 1.0 1.6330456160563258 0.8248924524345709 20.59405423301431 -6.697730763890142 1.838726227039708 1.3939571354811287 0.8273757257381215 0.4069487774499595 0.2673276121322649 0.4002471029960552 2.629147488052806 0.11605160431523268 0.29931915434921247 2.005715063119073e-07 6.697730763890142 -0.5665814097430072 FISDIANDALQHCK(ub)MK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FISDIANDALQHCKMK 16 1 Q12962;A0A087WWP5 Q12962 TAF10 Transcription initiation factor TFIID subunit 10 1 11466600.0 5204400.0 3271700.0 2990500.0 True False 7895455.2926049465 2687839.5730912266 2399426.3642172897 1.0 0.34042869897682976 0.3038996834627946 22.91259103103278 -13.677547550668466 0.41481550700141845 9.999901255755082 0.3024424064950804 0.9998526163290212 0.0038834249937110743 21.970884456698236 0.21372267065094386 177.15210217442984 0.008985658895275809 2.1011277051135845e-14 13.677547550668466 -9.697458849260002 FISLASLEYSDYSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FISLASLEYSDYSK 14 0 Q14232;H0YGG4;Q14232-2;F5H0D0 Q14232 EIF2B1 Translation initiation factor eIF-2B subunit alpha 0 3818580.0 692230.0 953750.0 2172600.0 False True 948166.137812358 911610.1713705149 1659476.6261015376 1.0 0.9614456106540714 1.750196046792327 19.854780344950473 -6.8954107520739 0.9898378993068238 0.9629509836897563 1.8256835759845804 0.9841409993643433 0.04572288724260461 0.11486236137975063 0.1970881083981083 0.03492196808612149 0.08893841164719966 1.2722991819057373e-07 6.8954107520739 0.8627325922948241 FISVGYVDDTQFVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FISVGYVDDTQFVR 14 0 O19617;P10321;A0A140T9U8;A0A140T9H5;A2AEA2;A0A140T921;P10321-2;A0A140TA05;A0A140T9L3;A0A140T9E1;A0A140T942;F8W9Z8;A0A140TA12;A0A140T9Z7;Q5QT33;A0A140T9J9;A0A1W2PR11;A0A140T962;A0A140T9B3;P01889;A0A1W2PPR8;F6U0H7;P01893;P13747 O19617;Q5QT33;P01889;P01893;P13747 HLA-C;HLA-B;HLA-H;HLA-E HLA class I histocompatibility antigen, Cw-7 alpha chain;HLA class I histocompatibility antigen, B-7 alpha chain;Putative HLA class I histocompatibility antigen, alpha chain H;HLA class I histocompatibility antigen, alpha chain E 0 5719000.0 1963100.0 3755900.0 0.0 False True 2573643.110687444 3195534.3603835325 0.0 1.0 1.2416384956848099 0.0 21.295380576985618 -6.90099780791846 1.296487169770842 1.1259114014047364 1.0611780873526574e-20 0.9475275199730624 0.12312204892483278 0.13386312892300803 0.45154994771174445 0.07758778723580197 0.15448119245175418 1.2560363034646853e-07 6.90099780791846 -1.1259114014047364 down FISVGYVDDTQFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FISVGYVDDTQFVR 14 0 O19617;P10321;A0A140T9U8;A0A140T9H5;A2AEA2;A0A140T921;P10321-2;A0A140TA05;A0A140T9L3;A0A140T9E1;A0A140T942;F8W9Z8;A0A140TA12;A0A140T9Z7;Q5QT33;A0A140T9J9;A0A1W2PR11;A0A140T962;A0A140T9B3;P01889;A0A1W2PPR8;F6U0H7;P01893;P13747 O19617;Q5QT33;P01889;P01893;P13747 HLA-C;HLA-B;HLA-H;HLA-E HLA class I histocompatibility antigen, Cw-7 alpha chain;HLA class I histocompatibility antigen, B-7 alpha chain;Putative HLA class I histocompatibility antigen, alpha chain H;HLA class I histocompatibility antigen, alpha chain E 0 10446100.0 1963100.0 3696800.0 4786200.0 False True 2688911.1207827497 3533463.1523171845 3655798.1348831663 1.0 1.3140870016144615 1.3595831065695296 21.35859063850851 -12.441012243556253 0.2984648097437141 5.603021794591055e-06 1.3716487321465 0.9995305934930706 0.0034636660628948215 6.70572643742151 0.1673310121191656 4.098517392655382 0.016547773712099895 3.6223278626757763e-13 12.441012243556253 1.3716431291247055 FISVGYVDDTQFVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FISVGYVDDTQFVR 14 0 O19617;P10321;A0A140T9U8;A0A140T9H5;A2AEA2;A0A140T921;P10321-2;A0A140TA05;A0A140T9L3;A0A140T9E1;A0A140T942;F8W9Z8;A0A140TA12;A0A140T9Z7;Q5QT33;A0A140T9J9;A0A1W2PR11;A0A140T962;A0A140T9B3;P01889;A0A1W2PPR8;F6U0H7;P01893;P13747 O19617;Q5QT33;P01889;P01893;P13747 HLA-C;HLA-B;HLA-H;HLA-E HLA class I histocompatibility antigen, Cw-7 alpha chain;HLA class I histocompatibility antigen, B-7 alpha chain;Putative HLA class I histocompatibility antigen, alpha chain H;HLA class I histocompatibility antigen, alpha chain E 0 12097900.0 7307600.0 1927300.0 2863000.0 False True 6076593.181570362 1916917.2523609027 3461640.062983657 1.0 0.3154592047028426 0.5696678977099257 22.534831278258807 -10.288281595848034 5.6500959316265185 1.000053078434163 0.4425635512065803 0.8650715946980323 0.10378026434122144 6.9395496426768e-05 8.74134151577319e-06 0.10049432789360205 0.03349493628820894 5.148946794349148e-11 10.288281595848034 -0.5574895272275827 FITDNTVEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 FITDNTVEER 10 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 11668800.0 3559200.0 5069500.0 3040100.0 False True 4666145.667341826 4313150.360756225 2725539.614698381 1.0 0.9243497027844199 0.5841094147090882 22.153799915281382 -6.942193185275223 0.6388420152727919 1.0037219228135372 0.4861204176215666 0.9984371896933298 0.0071505352033747974 0.08678040916175 0.05016072390188482 0.007082089571724326 0.02901268540562451 1.1423700663769213e-07 6.942193185275223 -0.5176015051919707 FITDNTVEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 FITDNTVEER 10 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 14000700.0 5735000.0 3385200.0 4880500.0 False True 5552945.56418028 4736928.013584784 3602150.6381384023 1.0 0.8530478029787861 0.6486918692980467 22.404821822507177 -6.966485101112943 0.33158173037524546 1.0244423327070906 0.4705916727960241 0.9999405603864123 0.001110628275007888 0.07746061354662072 0.013102613997427801 0.002965305093264558 0.017801831668391922 1.080226678454318e-07 6.966485101112943 -0.5538506599110665 FITDNTVEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FITDNTVEER 10 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 9280200.0 3559200.0 2580700.0 3140300.0 False True 4875132.423763409 2466676.1407663277 2398625.816508631 1.0 0.5059711052653112 0.49201244356291496 22.217009976804274 FITIFGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FITIFGTR 8 0 P08758;D6RBL5;D6RBE9 P08758 ANXA5 Annexin A5;Annexin 0 143806000.0 44245000.0 41942000.0 57619000.0 False True 58005623.46918951 35684417.08863549 51657138.60047567 1.0 0.6151889240116479 0.8905539758212249 25.789689436138584 -9.965507934669015 6.132166594524841 1.0000001120070183 0.7528714499164114 0.5178184528352043 0.11241731165484219 1.720342349569573e-07 2.9094980664564485e-08 0.10884764262451774 0.036282531322037966 1.0826599344782934e-10 9.965507934669015 -0.2471286620906069 FITIFGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FITIFGTR 8 0 P08758;D6RBL5;D6RBE9 P08758 ANXA5 Annexin A5;Annexin 0 125114000.0 60726000.0 17107000.0 47281000.0 False True 58798286.36973188 23937914.3118265 34896687.70040407 1.0 0.4071192510832975 0.5934983798842163 25.809270773662373 -10.524806395338919 6.83539073190446 1.0002822069639885 0.5003088154837623 0.9055179103756593 0.07608896071111923 0.0003274094693415965 2.2761224516303973e-05 0.07371296723595672 0.02455760647203292 2.98671377292396e-11 10.524806395338919 -0.49997339148022624 FITIFGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FITIFGTR 8 0 P08758;D6RBL5;D6RBE9 P08758 ANXA5 Annexin A5;Annexin 0 63123000.0 21657000.0 20233000.0 21233000.0 False True 32855252.338779826 16622263.068849467 17036288.243245494 1.0 0.5059240725790993 0.5185255638148657 24.969620686734658 -9.971240287508396 5.467729088918788 1.000001156752063 0.5122248181960388 0.999499678743821 0.005144537257615419 7.254154267873782e-08 1.3656679509353006e-08 0.004981188579976934 0.0016603922597431423 1.0684635535362205e-10 9.971240287508396 -0.4877763385560242 FITIFGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FITIFGTR 8 0 P08758;D6RBL5;D6RBE9 P08758 ANXA5 Annexin A5;Annexin 0 138003000.0 44245000.0 35038000.0 58720000.0 False True 60603572.17616664 33489905.304828353 44851545.37636119 1.0 0.5526061270361686 0.7400808857600609 25.852899497661475 -10.207824503615191 5.448784098147231 1.0000170682261715 0.6463435063980765 0.8259290363514158 0.07653624975428897 1.586997389434435e-05 2.307332081245321e-06 0.07410947742762239 0.024701968389941528 6.196914389227532e-11 10.207824503615191 -0.35367356182809506 FITIFGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FITIFGTR 8 0 P08758;D6RBL5;D6RBE9 P08758 ANXA5 Annexin A5;Annexin 0 84075000.0 60726000.0 23349000.0 0.0 False True 50496359.6179378 23223214.302586373 0.0 1.0 0.45989878237354753 0.0 25.58967604909665 -8.059123388668185 0.5692377874911158 1.0176730834867551 1.6692551463053202e-18 0.9900581575068107 0.04074955834635272 0.11342625926911767 0.16726399599285263 0.047886078050042524 0.07537952754528873 8.727233811838823e-09 8.059123388668185 -1.0176730834867551 FITIFGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FITIFGTR 8 0 P08758;D6RBL5;D6RBE9 P08758 ANXA5 Annexin A5;Annexin 0 93819000.0 21657000.0 42938000.0 29224000.0 False True 28035413.42329241 40548462.55446456 23905531.863562033 1.0 1.4463301090746905 0.8526905418737579 24.740747008827107 -6.705576109717136 1.8113472110337565 1.2756347025186492 0.8542823468714876 0.4438824372802075 0.18821752497978606 0.3840474857041557 2.453469490147512 0.08278578556293553 0.21142137163117908 1.9698079698922676e-07 6.705576109717136 -0.42135235564716156 FITRPDVKQSK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 FITRPDVKQSK 11 2 J3KR97;Q9BTW9;Q9BTW9-4;Q9BTW9-5 J3KR97 TBCD Tubulin-specific chaperone D 1 2775600.0 732920.0 1204900.0 837780.0 True False 960865.217607376 1025133.6166634148 751094.5621532229 1.0 1.0668859668123607 0.7816856603712877 19.873974550049024 -6.844912088863678 1.2594638648973586 1.0355916926794184 0.7713600625368418 0.9325591809638576 0.03162559129972524 0.16314316466751505 0.5005701356712058 0.01967242303179573 0.04539735457227815 1.4291832286064264e-07 6.844912088863678 -0.26423163014257667 FITRPDVKQSK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 FITRPDVKQSK 11 2 J3KR97;Q9BTW9;Q9BTW9-4;Q9BTW9-5 J3KR97 TBCD Tubulin-specific chaperone D 1 4012180.0 969380.0 1123800.0 1919000.0 True False 938607.5625117846 1572539.2005395794 1416356.3312340113 1.0 1.6753958345821824 1.5089973571529032 19.840162558875324 -10.106057694384294 4.485959336995837 0.9999527571315405 1.5921965957488566 0.9440958263669962 0.06793189430834155 10427282.868641846 11745397.9877252 4831.878636856513 0.02325489502174886 7.833255740050318e-11 10.106057694384294 0.5922438386173161 FITRPDVKQSK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 FITRPDVKQSK 11 2 J3KR97;Q9BTW9;Q9BTW9-4;Q9BTW9-5 J3KR97 TBCD Tubulin-specific chaperone D 1 10046100.0 1428100.0 1471700.0 7146300.0 True False 2166532.1080949055 1209063.636555416 5733830.672665437 1.0 0.5580640287018782 2.646547748469493 21.046956186892203 -6.851419379229941 1.228280759888418 0.7638598196950686 2.732322518510298 0.9423377396132686 0.21579319567154148 0.15590308114543827 0.4519127118587053 0.1374259106977214 0.3183019932437267 1.4079285665900928e-07 6.851419379229941 1.9684626988152296 up FITRPDVKQSK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FITRPDVKQSK 11 2 J3KR97;Q9BTW9;Q9BTW9-4;Q9BTW9-5 J3KR97 TBCD Tubulin-specific chaperone D 1 2664310.0 732920.0 873190.0 1058200.0 True False 1003900.3304182626 834609.5785468097 808274.954313102 1.0 0.831366972654626 0.8051346630958316 19.937184611571915 -13.999999999254207 0.2619345384253495 2.2470252367161283 0.7957231025395038 0.9995663023759722 0.0017981418452489204 14.50346994264721 0.16196355192380504 9.584458469504128 0.011352722234934538 1.0000000017172513e-14 13.999999999254207 -1.4513021341766246 FITVGWGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FITVGWGR 8 0 O95163 O95163 IKBKAP Elongator complex protein 1 0 9142000.0 3263300.0 2936000.0 2942700.0 False True 4950664.679186405 2412047.8609272954 2361074.055168774 1.0 0.48721697332239694 0.47692061736582697 22.239190804615394 FITVGWGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FITVGWGR 8 0 O95163 O95163 IKBKAP Elongator complex protein 1 0 13691500.0 3263300.0 5255000.0 5173200.0 False True 4224406.17925982 4962554.630483746 4231730.68151448 1.0 1.1747342513719314 1.0017338536930045 22.010317126707843 -6.643896355355225 2.0306235280401035 1.1139294651762086 1.002461182387195 0.16959623496685772 0.07469173783836591 0.5236323012759166 4.131375669294767 0.02990630550608083 0.08270163793190596 2.2704066211686981e-07 6.643896355355225 -0.11146828278901366 FIVIADFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FIVIADFR 8 0 P49247 P49247 RPIA Ribose-5-phosphate isomerase 0 23001100.0 4134600.0 12059000.0 6807500.0 False True 5352321.205150518 11387906.04928706 5568604.85084857 1.0 2.127657442966712 1.0404093172677908 22.351733267361208 -6.637646936436471 2.0528540169441754 1.7387306340406998 1.044898331371607 0.14568547789768005 0.4827747894154868 0.539327682325078 4.34089999070552 0.19170091707985065 0.534631705972736 2.3033135557328793e-07 6.637646936436471 -0.6938323026690929 FIWNHGITLPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FIWNHGITLPLK 12 0 Q15545 Q15545 TAF7 Transcription initiation factor TFIID subunit 7 0 3607110.0 784310.0 1369800.0 1453000.0 False True 1028238.0052688454 1165431.1794385803 1302657.4981601743 1.0 1.1334255040824561 1.266883242483902 19.971742811753195 -6.971122429622161 0.22980675724322613 0.9455919690819293 1.4585291571760524 0.9999898589229838 0.000346918602874472 0.07594019421108533 0.007714584772849578 0.003434031612549429 0.013259978191326101 1.0687535501850598e-07 6.971122429622161 0.512937188094123 FIWNHGITLPLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIWNHGITLPLK 12 0 Q15545 Q15545 TAF7 Transcription initiation factor TFIID subunit 7 0 4384800.0 2463900.0 0.0 1920900.0 False True 2385684.8431706717 0.0 1417758.664235233 1.0 0.0 0.5942774328695379 21.18597204017563 -10.06531354218991 6.531535339485079 1.000000551990992 0.29713871643476664 0.6509706719348798 0.24261274603025126 1.950123054295662e-06 2.7948536822382745e-07 0.23490896499344296 0.07830292707939972 8.603723755560957e-11 10.06531354218991 -0.7028618355562254 FIWNHGITLPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIWNHGITLPLK 12 0 Q15545 Q15545 TAF7 Transcription initiation factor TFIID subunit 7 0 5643610.0 784310.0 1711500.0 3147800.0 False True 1074290.6021807955 1635880.2708263525 2404354.47097598 1.0 1.5227539620150614 2.238085734060386 20.034952873276087 -6.966738290667763 0.32684667004337253 0.9095825235744198 2.874564733740579 0.9999446235586967 0.003776428947980536 0.07737593308916464 0.012806056241830462 0.010558342464925327 0.06255398365938472 1.079597100105662e-07 6.966738290667763 1.9649822101661591 FIWNHGITLPLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIWNHGITLPLK 12 0 Q15545 Q15545 TAF7 Transcription initiation factor TFIID subunit 7 0 6221300.0 2463900.0 1344900.0 2412500.0 False True 2048842.0192773575 1337654.7567582526 2916942.5958603113 1.0 0.6528833088019417 1.4237030324520286 20.966377315609908 -6.784275702950013 1.5191207138996032 0.8045452667383259 1.430658086301559 0.7822569558213208 0.1470830785040009 0.243986935509504 1.1123336008083022 0.07623719431557356 0.17926269874480183 1.6433281588092576e-07 6.784275702950013 0.6261128195632331 FIYEGSSDFSCLPTFGVIIGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FIYEGSSDFSCLPTFGVIIGQK 22 0 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ET17;A0A2R8Y7L2;E7EPL9;E7ER27 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 48932000.0 15013000.0 14325000.0 19594000.0 False True 22775818.597317323 11768591.828264145 15721237.311644737 1.0 0.5167143291899209 0.6902600336611603 24.4409995718093 -10.036152866265752 4.884442702166829 1.0000077696442384 0.6034871814202262 0.8743759618144483 0.07084973718608373 5.9946295509681205e-06 1.182900311680661e-06 0.06860130673463496 0.022866654347790186 9.201256419445129e-11 10.036152866265752 -0.39652058822401226 FIYEGSSDFSCLPTFGVIIGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FIYEGSSDFSCLPTFGVIIGQK 22 0 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ET17;A0A2R8Y7L2;E7EPL9;E7ER27 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 29789000.0 15013000.0 4208000.0 10568000.0 False True 19434624.45047277 3973821.1008707173 8644732.436836977 1.0 0.20447120606820113 0.4448108816749831 24.21212589390175 -10.161740150202196 5.247378940097277 1.0000269691700387 0.3246410438822234 0.9132567353745609 0.09811826169835842 3.09583589234725e-05 4.945500756995736e-06 0.09500638203022087 0.03166753279286676 6.890644583960503e-11 10.161740150202196 -0.6753859252878154 FIYFNHMNLAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FIYFNHMNLAEK 12 0 P86790;P86791 P86790 CCZ1B;CCZ1 Vacuolar fusion protein CCZ1 homolog B;Vacuolar fusion protein CCZ1 homolog 0 3546260.0 976960.0 858300.0 1711000.0 False True 1338168.5133512884 820377.4679814543 1306897.0391511226 1.0 0.6130599097171355 0.9766311388377761 20.351828372947907 -10.548312525918435 9.064333695248404 1.0000165133429304 0.794845525183013 0.29802050093083143 0.14842733275034695 4.953617480937769e-05 2.4683323737495756e-06 0.14372569906701402 0.04790471565534004 2.829355209451954e-11 10.548312525918435 -0.2051709881599174 FIYGNQDLFATSQSK(ub)EFDPLGPLPPGWEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIYGNQDLFATSQSKEFDPLGPLPPGWEK 29 1 A0A590UJQ1;Q96J02-3;Q96J02-2;Q96J02;A0A590UK44;A0A590UJW8;A0A590UK95 A0A590UJQ1 ITCH E3 ubiquitin-protein ligase Itchy homolog 1 75577500.0 49380000.0 6350500.0 19847000.0 True False 47812458.92924541 8886287.767420003 14648475.3027626 1.0 0.1858571587077387 0.30637360283937576 25.510883267634135 -10.589988616582716 6.496621722128671 1.0016353699867035 0.24611538077355724 0.9811938906335556 0.04920063228952449 0.0011672300065550276 7.366546525993791e-05 0.047712990955739075 0.015879435790016935 2.5704631570332716e-11 10.589988616582716 -0.7555199892131463 FIYGNQDLFATSQSK(ub)EFDPLGPLPPGWEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FIYGNQDLFATSQSKEFDPLGPLPPGWEK 29 1 A0A590UJQ1;Q96J02-3;Q96J02-2;Q96J02;A0A590UK44;A0A590UJW8;A0A590UK95 A0A590UJQ1 ITCH E3 ubiquitin-protein ligase Itchy homolog 1 381410000.0 118460000.0 141430000.0 121520000.0 True False 179712480.5860394 116190711.50236648 97501518.73589179 1.0 0.6465366852845752 0.5425417222996476 27.421115363018245 -13.999999998831202 0.171502954592392 2.789647453999157 0.45225877111021245 0.9995108907144277 0.004330150940609849 12.106532009160212 0.13117035914750566 7.2091947662976 0.08363972822648681 1.0000000026912578e-14 13.999999998831202 -2.3373886828889443 FIYGNQDLFATSQSK(ub)EFDPLGPLPPGWEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FIYGNQDLFATSQSKEFDPLGPLPPGWEK 29 1 A0A590UJQ1;Q96J02-3;Q96J02-2;Q96J02;A0A590UK44;A0A590UJW8;A0A590UK95 A0A590UJQ1 ITCH E3 ubiquitin-protein ligase Itchy homolog 1 81691000.0 49380000.0 29372000.0 2939000.0 True False 41061657.90491331 29213767.206114512 3553531.3115993636 1.0 0.7114609759246686 0.08654135007963619 25.29128854306841 -7.333704358417808 0.6225961219736279 0.9993494855324034 2.4137818848702357e-24 0.9956108333961672 0.025258323288424287 0.10318306828595727 0.07931805307172371 0.023604306288912948 0.06345158379443046 4.637625139526959e-08 7.333704358417808 -0.9993494855324034 down FIYGNQDLFATSQSK(ub)EFDPLGPLPPGWEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FIYGNQDLFATSQSKEFDPLGPLPPGWEK 29 1 A0A590UJQ1;Q96J02-3;Q96J02-2;Q96J02;A0A590UK44;A0A590UJW8;A0A590UK95 A0A590UJQ1 ITCH E3 ubiquitin-protein ligase Itchy homolog 1 353752000.0 118460000.0 136650000.0 98642000.0 True False 153348805.19569728 129045307.37499587 80690168.15239148 1.0 0.8415149189477785 0.5261871329836453 27.192241685110695 -6.960146448466998 0.4333668665143793 1.0120870875208716 0.34345523977406694 0.9997755865976219 0.002950154363809922 0.07964887539885261 0.020938497722199013 0.004125779549469086 0.026162146167730316 1.096108515001766e-07 6.960146448466998 -0.6686318477468047 FIYMAVQHYIETLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FIYMAVQHYIETLQR 15 0 Q06124;Q06124-1 Q06124 PTPN11 Tyrosine-protein phosphatase non-receptor type 11 0 7443700.0 4919600.0 0.0 2524100.0 False True 4763429.9908528915 0.0 1862962.4886231204 1.0 0.0 0.39109685503944125 22.18356935478261 -10.684108349766063 6.656257632318078 1.006351023169143 0.19554842751972937 0.8494243319549127 0.15966462247564514 0.01502437176522873 0.0007130230945729005 0.15434987680806841 0.05153153531888898 2.0696249449155105e-11 10.684108349766063 -0.8108025956494137 FK(ub)AQQDQLVLIFAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FKAQQDQLVLIFAGK 15 1 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 6037400.0 2750200.0 2075300.0 1211900.0 True False 3605538.832974682 1765673.3294560397 1086504.2133656684 1.0 0.48971136111694685 0.3013430900893303 21.781783449752837 -13.999999999999998 0.13847770162209402 3.4344827424165887 0.06389611890871252 0.9996090721925623 0.005835585711384014 11.932779533133635 0.11647702077462797 7.8568244095943065 0.2120652490019228 1.0000000000000041e-14 13.999999999999998 -3.3705866235078763 FK(ub)AQQDQLVLIFAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FKAQQDQLVLIFAGK 15 1 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 16503800.0 7108700.0 5220100.0 4175000.0 True False 6883038.209605655 7304513.152461878 3081442.2526847296 1.0 1.0612338519736868 0.44768634995871576 22.714614088089167 -6.8823394026361555 1.0666184290789635 1.0392704280594134 0.40219735128975426 0.9755259567712488 0.04316712365100931 0.12558012551939307 0.2599095183829419 0.031106131896096102 0.07569334354931921 1.311174810877461e-07 6.8823394026361555 -0.6370730767696591 down FK(ub)AQQDQLVLIFAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FKAQQDQLVLIFAGK 15 1 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 14911100.0 7108700.0 6265600.0 1536800.0 True False 5911199.01880635 6231845.9691757765 1858137.7746396363 1.0 1.0542439781420478 0.314341941242041 22.495019363523443 -6.889261109833835 1.0267636277162335 1.0404630132248083 0.25162182417044543 0.980420411408028 0.0471185829598522 0.11974389735236037 0.22537574246331038 0.035000055468911544 0.08702520097876607 1.2904431902591023e-07 6.889261109833835 -0.7888411890543628 down FK(ub)EIAEAYDVLSDPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FKEIAEAYDVLSDPR 15 1 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 9972500.0 1958500.0 3244900.0 4769100.0 True False 1896328.4895286974 4540605.491929958 3519929.6400667666 1.0 2.394419277568547 1.8561813839234096 20.854777464554736 -10.588280366761255 7.033063144159498 0.9985690811047623 2.1253003307458536 0.8535464016076771 0.2197346999434979 0.00493379702570689 0.00028882695102259537 0.21291304687639648 0.07091906945542088 2.580593703222138e-11 10.588280366761255 1.1267312496410913 FK(ub)EIAEAYDVLSDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FKEIAEAYDVLSDPR 15 1 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 24151000.0 2993700.0 8907300.0 12250000.0 True False 4541661.768786302 7317722.721947456 9828782.13063426 1.0 1.611243437862397 2.1641378488783567 22.114788837530067 -6.97231837468352 0.19501293825713872 0.6489623462656671 3.1416029903973937 0.9999952697999009 0.001034054755451089 0.07555734892082436 0.006258571015952319 0.018709628158852944 0.05945888808323689 1.0658145023572293e-07 6.97231837468352 2.4926406441317264 FK(ub)EIAEAYDVLSDPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FKEIAEAYDVLSDPR 15 1 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 6970200.0 1958500.0 2759100.0 2252600.0 True False 1628579.526261091 2744236.1806615274 2723608.2451543817 1.0 1.685048925404197 1.6723827121953747 20.635182739989013 -10.066098041498796 4.71773980990913 0.9999738467570052 1.6787158188144213 0.9997388644280715 0.00517095994685312 3587353.022741586 0.13252785667189276 1038.7371134481068 0.0017701571205312476 8.58819622040428e-11 10.066098041498796 0.6787419720574162 FK(ub)EIAEAYDVLSDPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FKEIAEAYDVLSDPR 15 1 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 24647300.0 2993700.0 8705600.0 12948000.0 True False 3875403.6646493184 8221125.707162574 10591596.857699206 1.0 2.12135984237051 2.7330306141560685 21.885915159622517 -9.078778690475746 0.1961106518064063 3.0588948768658187e-12 3.3935229181876743 0.9995829810190009 0.01465482879315296 0.5375073502480908 0.06730605367102929 0.6815810332965904 0.3438142451345632 8.341061234838228e-10 9.078778690475746 3.3935229181846154 FK(ub)GYQQQDSQELLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FKGYQQQDSQELLR 14 1 Q9Y5T5-2;Q9Y5T5;Q9Y5T5-3;Q9Y5T5-5 Q9Y5T5-2 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 16893500.0 3724000.0 6021900.0 7147600.0 True False 4882200.063267302 5123455.993182353 6408034.916620558 1.0 1.0494154124756607 1.3125301777027396 22.219099984551754 -6.938412454811531 0.6741699893575168 0.9969498543738667 1.3802886677891835 0.9979485008636538 0.006213011811639531 0.08849835119176172 0.05796391226017193 0.0059775005776395536 0.022808695312244855 1.1523583290899525e-07 6.938412454811531 0.3833388134153167 FK(ub)GYQQQDSQELLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FKGYQQQDSQELLR 14 1 Q9Y5T5-2;Q9Y5T5;Q9Y5T5-3;Q9Y5T5-5 Q9Y5T5-2 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 22639700.0 6737300.0 7094900.0 8807500.0 True False 6523428.09931157 9927930.569414727 6500551.530663665 1.0 1.5218885558748538 0.9964931676566928 22.63719887766876 -10.752459113264473 3.0137206351741828 0.9534868845507932 1.2591908618441587 0.24499422951793404 0.21449176969425512 29754881.18682747 32232418.426853202 10273939.19726749 0.07849595164812954 1.7682386810609068e-11 10.752459113264473 0.3057039772933655 FK(ub)GYQQQDSQELLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FKGYQQQDSQELLR 14 1 Q9Y5T5-2;Q9Y5T5;Q9Y5T5-3;Q9Y5T5-5 Q9Y5T5-2 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 38571100.0 7996100.0 11564000.0 19011000.0 True False 12130668.293213148 9500313.850055601 15253467.51718271 1.0 0.7831649188998784 1.25743010595028 23.532155696677055 -6.78236911488729 1.526369703279321 0.877600859870174 1.261488213483517 0.7757712118084595 0.09179541238416966 0.24691041231912725 1.1363235926395634 0.047357483158705214 0.11153723161931706 1.6505583619270313e-07 6.78236911488729 0.38388735361334303 FK(ub)GYQQQDSQELLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FKGYQQQDSQELLR 14 1 Q9Y5T5-2;Q9Y5T5;Q9Y5T5-3;Q9Y5T5-5 Q9Y5T5-2 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 12847200.0 3724000.0 4040900.0 5082300.0 True False 5100863.437315959 3862359.67653065 3881965.413254094 1.0 0.7571972321931046 0.7610408435668216 22.282310046074645 -9.956493324756677 5.341998781024429 1.0000006417872298 0.7591190378790184 0.9998090770195652 0.0015691477760038832 1.1993523594977073e-08 2.3415336653759097e-09 0.001519324840630623 0.0005064402665145576 1.1053674590991606e-10 9.956493324756677 -0.24088160390821145 FK(ub)GYQQQDSQELLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FKGYQQQDSQELLR 14 1 Q9Y5T5-2;Q9Y5T5;Q9Y5T5-3;Q9Y5T5-5 Q9Y5T5-2 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 16803000.0 6737300.0 6748400.0 3317300.0 True False 5602363.46299661 6712045.02974747 4010932.0925377863 1.0 1.1980738261771595 0.7159357151726828 22.417604153103035 -6.795126852948212 1.475551813489654 1.1099683450783977 0.7100403274556534 0.8175958901641296 0.08450910008924334 0.22777924436729988 0.9794918245012718 0.045066204512854424 0.10514172810870283 1.6027771675976365e-07 6.795126852948212 -0.3999280176227443 FK(ub)GYQQQDSQELLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FKGYQQQDSQELLR 14 1 Q9Y5T5-2;Q9Y5T5;Q9Y5T5-3;Q9Y5T5-5 Q9Y5T5-2 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 26614000.0 7996100.0 11947000.0 6670900.0 True False 10351109.076695213 11282138.947742963 5456864.6492142035 1.0 1.0899449386678668 0.5271768086668072 23.303282018769504 -6.865971267829836 1.1551060002170992 1.0498246971145788 0.4966345009595603 0.960499137174876 0.049058566078677465 0.14078110683987632 0.3535930923965143 0.03303362047288486 0.07771119818671886 1.3615347562658936e-07 6.865971267829836 -0.5531901961550185 FK(ub)NWDDVLTVDYTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FKNWDDVLTVDYTR 14 1 Q13045;Q13045-2;Q13045-3 Q13045 FLII Protein flightless-1 homolog 1 4683000.0 1252500.0 1832900.0 1597600.0 True False 1041509.245158039 1823025.8038978365 1931650.7735322004 1.0 1.7503692956860981 1.8546650281909796 19.99024421512084 -11.17076610059808 0.35308865209011053 3.2029821351049776e-11 1.8712219150532032 0.9994331490242194 0.009063915255153538 3.1648196228603878 0.17803861115513983 2.53846691455959 0.0307226505295186 6.748914083123959e-12 11.17076610059808 1.8712219150211735 FK(ub)QISQAYEVLSDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FKQISQAYEVLSDAK 15 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 16705500.0 4447800.0 4488800.0 7768900.0 True False 5831108.872556472 3819088.5372053534 6965048.752550991 1.0 0.6549506484400437 1.1944638498058737 22.475338828876694 -6.733969970382915 1.7088753874806892 0.7932723436827145 1.1943752874458369 0.5775123797416493 0.1450108113877116 0.32884827854399323 1.883105077022968 0.06719970108112963 0.16599962913688085 1.8451429985626373e-07 6.733969970382915 0.4011029437631224 FK(ub)QISQAYEVLSDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FKQISQAYEVLSDAK 15 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 34616700.0 7309600.0 5901100.0 21406000.0 True False 7077560.749072751 8257440.003829961 15799126.433765123 1.0 1.1667070473272574 2.2322841150936084 22.754820796642743 -6.934511297230483 0.7087873665090164 0.9861874023672288 2.4784911064723487 0.9973529365607031 0.028084821264451682 0.09036206031213566 0.06669525169490628 0.026311814893889077 0.09413966028745004 1.1627563040226474e-07 6.934511297230483 1.49230370410512 up FK(ub)QISQAYEVLSDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FKQISQAYEVLSDAK 15 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 80078000.0 16332000.0 33679000.0 30067000.0 True False 24776838.029133823 27668719.314771984 24124244.27116575 1.0 1.1167171243658187 0.9736611363725783 24.562488749561034 -6.689769876719873 1.8670208429377086 1.073189418637111 0.9741541716367015 0.3694241371667719 0.04936537431767821 0.4171749964443424 2.8191581106049552 0.021152598952154277 0.05510313701322861 2.0428201042562422e-07 6.689769876719873 -0.09903524700040944 FK(ub)QISQAYEVLSDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FKQISQAYEVLSDAK 15 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 23614900.0 4447800.0 5622100.0 13545000.0 True False 6092271.857275488 5373697.032201488 10345949.968031537 1.0 0.8820514182708595 1.6982088472752968 22.538548890399586 -6.870217478091575 1.1328832690400117 0.9331975317356845 1.7462176602698436 0.9649028975116871 0.0674755784972757 0.13664971054996872 0.3276437871336106 0.04621613237952263 0.10946514754056658 1.3482875426009854e-07 6.870217478091575 0.8130201285341591 FK(ub)QISQAYEVLSDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FKQISQAYEVLSDAK 15 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 31561400.0 7309600.0 8277800.0 15974000.0 True False 6078256.270185389 8233205.84838534 19314089.544568945 1.0 1.3545341759889673 3.1775707844545784 22.53522607207702 -6.939182057271073 0.667128275071896 0.9792197113735526 3.6575800733379946 0.9980548090303739 0.042075333832591044 0.08814174685965513 0.056323584228907715 0.04070771282248854 0.15747899027697407 1.1503180718085958e-07 6.939182057271073 2.678360361964442 up FK(ub)QISQAYEVLSDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FKQISQAYEVLSDAK 15 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 77143000.0 16332000.0 36828000.0 23983000.0 True False 21142095.95184979 34778489.42558619 19618340.086360812 1.0 1.644987777219094 0.9279278710606903 24.333615071653483 -6.66971676128687 1.9388202549868665 1.4117996785950866 0.9308564666605088 0.2776591228316305 0.2739955697790571 0.46173248729462946 3.3460607205598234 0.11379429078779482 0.3040930441718784 2.13935688304552e-07 6.66971676128687 -0.4809432119345778 FK(ub)QVAEAYEVLSDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FKQVAEAYEVLSDAK 15 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 11871000.0 2663900.0 2656100.0 6551000.0 True False 3492398.6972442963 2259820.2333967085 5873165.3616292635 1.0 0.6470682271127397 1.6816995626139504 21.735786837828517 -6.814646893224545 1.3949134766738511 0.8086845265413596 1.701788992994912 0.8716174578657983 0.15386909003418542 0.2005294473188573 0.7680914495934289 0.08671346816422049 0.2001975203163762 1.532332831410454e-07 6.814646893224545 0.8931044664535523 FK(ub)QVAEAYEVLSDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FKQVAEAYEVLSDAK 15 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 18978900.0 2731100.0 7220500.0 9027300.0 True False 4143278.3701547557 5931945.360976011 7243050.198193858 1.0 1.4317033110074249 1.7481447180492782 21.98234132175581 -6.9745175822807495 0.10386656459224385 0.26620699557719935 2.921686059856833 0.9999997006999082 0.0001676553180408872 0.07486220215601946 0.0030568018354446332 0.02714943634416375 0.05046620142882403 1.0604310062747257e-07 6.9745175822807495 2.6554790642796338 FK(ub)QVAEAYEVLSDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FKQVAEAYEVLSDAK 15 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 14244700.0 2731100.0 5292000.0 6221600.0 True False 3535462.7880294533 4997495.547958127 5089332.6390069 1.0 1.4135336298486574 1.4395096042980897 21.75346764384826 -11.811473625619374 0.43959072310107217 2.874969616504617e-22 1.4398998223207236 0.9997973867178135 0.0028659663202064882 5.117725698813129 0.21975403669228102 4.783740566580804 0.006003603402431407 1.5435701603451187e-12 11.811473625619374 1.4398998223207236 FK(ub)SQTDQLVLIFAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FKSQTDQLVLIFAGK 15 1 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 1 57177900.0 13535000.0 24407900.0 19235000.0 True False 13105338.833684433 34154101.75551701 14196776.462369058 1.0 2.606121229596239 1.0832819084295113 23.64365131870632 -6.633712491440721 2.06740221399737 2.0553048869113524 1.0895498043502638 0.13081212181357982 0.6883061995292458 0.549448867227753 4.4802916505703285 0.2718780815308218 0.7621691424396329 2.3242749872272745e-07 6.633712491440721 -0.9657550825610886 FK(ub)SQTDQLVLIFAGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FKSQTDQLVLIFAGK 15 1 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 1 83791600.0 26722600.0 33200000.0 23869000.0 True False 40540137.883745566 27275200.607216027 19151281.68784566 1.0 0.6727949639794375 0.47240297363478634 25.272847659870262 -9.188694586173726 0.1186639508851907 1.609305624195275 5.814122633339565e-13 0.9999234372618302 0.0019027223533423644 0.6390633889956328 0.04136007337216617 0.33403162772436024 0.2046317140413568 6.475978732373993e-10 9.188694586173726 -1.6093056241946937 FK(ub)SQTDQLVLIFAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FKSQTDQLVLIFAGK 15 1 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 1 30301500.0 10013700.0 8886800.0 11401000.0 True False 13716035.500067336 8494151.791282281 8708318.610965483 1.0 0.6192862209521535 0.6349005593433125 23.709360207609446 -9.941204386305575 6.991694951258539 1.0000000147511028 0.6270933901563749 0.9986867786600416 0.006374526954919006 1.4617457304151448e-09 2.2362492177193574e-10 0.006172109460000541 0.002057369728028701 1.1449739705757885e-10 9.941204386305575 -0.3729066245947279 FK(ub)SQTDQLVLIFAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FKSQTDQLVLIFAGK 15 1 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 1 47600300.0 13535000.0 24853900.0 9211400.0 True False 11254952.202166915 24720007.10758708 11137461.151298521 1.0 2.1963671336452 0.9895609462609913 23.424056594140595 -6.648145096718823 2.014965457421926 1.7774460196213857 0.9946071141334111 0.18666412373643437 0.5108531762579908 0.5130702295828983 3.9906333734231936 0.2057561723963538 0.5658571380266201 2.2483033277276623e-07 6.648145096718823 -0.7828389054879746 FK(ub)SQTDQLVLIFAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FKSQTDQLVLIFAGK 15 1 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 1 95457300.0 26722600.0 53429700.0 15305000.0 True False 34592932.48119655 50456290.226518996 12519647.042561492 1.0 1.4585722171413245 0.3619134356234966 25.04397398196271 -6.793105017781107 1.4837450357377744 1.25526407807464 0.34920343590146585 0.8112847153639714 0.19535760249754291 0.2307464452318537 1.0034220313605224 0.10361498239597139 0.2420677586862587 1.6102562082143058e-07 6.793105017781107 -0.9060606421731742 down FK(ub)TEAQAFTETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FKTEAQAFTETK 12 1 Q9NX02;A0A0G2JPQ2;A0A0G2JMG8;Q9NX02-5;A0A0G2JNC8;Q9NX02-3;A0A0G2JPB6;F5GYZ4;K7ELX1;K7EPE6;F5H5B1 Q9NX02 NLRP2 NACHT, LRR and PYD domains-containing protein 2 1 2975380.0 832120.0 931160.0 1212100.0 True False 1139777.251197463 890018.2722656539 925826.9439830945 1.0 0.7808703598274055 0.8122876141021504 20.120320472668055 -10.431852863264913 8.8863699935967 1.0000018181518344 0.7965789869985584 0.982424592421638 0.01282604034873312 4.620110402723129e-07 2.9529626890894755e-08 0.012418871183063104 0.004139586722368984 3.699534968912095e-11 10.431852863264913 -0.20342283115327597 FKDFYQFTFNFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FKDFYQFTFNFAK 13 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 0 54853000.0 16181000.0 14093000.0 24579000.0 False True 24547759.989555143 11577994.04088842 19720949.87664159 1.0 0.47165175339072707 0.8033706490951794 24.54908804722801 -10.331930273751269 6.612530667237254 1.00001385680286 0.6375112012429589 0.6142217737841336 0.1354236720859032 2.766587622676514e-05 2.7950404203520083e-06 0.13112841361135336 0.043707802222579785 4.65660849660277e-11 10.331930273751269 -0.36250265555990113 FKDFYQFTFNFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FKDFYQFTFNFAK 13 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 0 43022000.0 16181000.0 13387000.0 13454000.0 False True 20946623.475194808 12642001.68188125 11005510.04969763 1.0 0.6035341064325728 0.5254073556404191 24.32021436932046 -13.999999999999961 0.22835663355544994 3.4838875226868993 0.4868225927117814 0.9995075936614815 0.004610530727980275 13.24059943372613 0.15131911163287837 14.898128510698232 0.04097336851749876 1.00000000000009e-14 13.999999999999961 -2.9970649299751178 FKDIFQEIFDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FKDIFQEIFDK 11 1 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 4843420.0 520720.0 2144850.0 2177850.0 False True 682668.9626596534 1824846.7405598175 1952506.9734123452 1.0 2.673106352235908 2.860108017516205 19.38082663610713 -10.406259518782065 0.45380892531608763 5.454341231531117e-21 2.8630375691290633 0.9994074008498973 0.020357828549396422 1.8008751136561045 0.21316954181751666 2.195940982228332 0.041680121809041404 3.9241037497984994e-11 10.406259518782065 2.8630375691290633 FKDIFQEIFDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FKDIFQEIFDK 11 1 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 7610300.0 3055000.0 1293700.0 3261600.0 False True 2958020.6972224507 1810281.1565563758 2407289.114097374 1.0 0.6119906998136322 0.8138175356101437 21.49620071631008 -10.162555717924855 5.199719671367253 1.0000126926251758 0.7129041177116968 0.7295803302862345 0.08239546068432388 115419186.06345204 2.1467685134515255 17539.900338482745 0.0282061577829195 6.877716688010576e-11 10.162555717924855 -0.28710857491347896 FKDIFQEIFDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FKDIFQEIFDK 11 1 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 18512320.0 520720.0 6731000.0 11260600.0 False True 713244.2559288845 6433602.163559563 8601078.199336715 1.0 9.02019484921171 12.059092138267852 19.444036697630022 -8.823706655544404 0.45433362482895795 7.033181110661846e-13 12.360960103837991 0.9965056492265014 0.2757636518222292 0.3612613625653309 0.16504034696680606 1.4762400407322849 0.6739340706470383 1.5006981406604332e-09 8.823706655544404 12.360960103837288 FKDIFQEIFDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FKDIFQEIFDK 11 1 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 5096100.0 3055000.0 1395200.0 645900.0 False True 2540367.8594473484 1387683.780674484 780954.703695824 1.0 0.546253085163962 0.30741795948627654 21.276605991744358 -9.63519661425643 0.16754065207493457 1.5900506264522125 1.2116128022370473e-20 0.9996816616184175 0.005125071935346639 1.0863911028448698 0.069092508786011 0.47543496572248184 0.17200181635398745 2.3163457540620973e-10 9.63519661425643 -1.5900506264522125 FKDPLKDGEAK(ub)IK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FKDPLKDGEAKIK 13 3 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 42401900.0 2985900.0 13724000.0 25692000.0 True False 3865306.4108883343 12960247.335634416 21016319.62218161 1.0 3.3529676454953696 5.437167817531854 21.8821513534477 -7.358758201237708 0.23173537708062167 3.5280384036380355e-25 8.043283395715356 0.9999430183693142 0.013682423622430846 0.11999358231793018 0.017761372404843385 0.1477401605511358 0.39021865053597354 4.3776576876430204e-08 7.358758201237708 8.043283395715356 FKFQVVINGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FKFQVVINGR 10 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 16187400.0 0.0 5250400.0 10937000.0 False True 0.0 4313425.098437562 8775297.156142604 0.0 FKFQVVINGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FKFQVVINGR 10 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 12512500.0 0.0 6430300.0 6082200.0 False True 0.0 6072448.152312007 4975302.008642107 0.0 FKFTIGDHSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FKFTIGDHSR 10 1 O75083;D6RD66 O75083 WDR1 WD repeat-containing protein 1 0 14199700.0 3028600.0 3439800.0 7731300.0 False True 4594607.620318073 2825940.814719935 6203205.166250834 1.0 0.615055963043108 1.3501055321501867 22.13151022988258 -6.764386312499514 1.5957251109430912 0.7776246055058593 1.3534100157474684 0.708675868736196 0.16202863393745315 0.27562406025964703 1.384103984267387 0.08007544229841061 0.19162791539136048 1.7203376239282847e-07 6.764386312499514 0.5757854102416091 FKFTIGDHSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FKFTIGDHSR 10 1 O75083;D6RD66 O75083 WDR1 WD repeat-containing protein 1 0 18553500.0 3028600.0 7324500.0 8200400.0 False True 3920582.4026311734 6916885.136247041 6708011.34320949 1.0 1.764249396111403 1.710973180593685 21.90263655197503 -10.433727718668061 4.613260486244165 0.9981992051519862 1.737611288352838 0.9961025820134942 0.021749923909281176 0.00040367449314908214 4.9550426462749065e-05 0.02110285596343208 0.007019757756574684 3.683598448120193e-11 10.433727718668061 0.7394120832008518 FKGQILMPNIGYGSNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FKGQILMPNIGYGSNK 16 1 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 50848000.0 17663000.0 16680000.0 16505000.0 False True 23156364.04873534 14191409.01813076 14797220.927139517 1.0 0.6128513521493807 0.6390131410957693 24.464905407147512 -10.710164458564506 6.760127103107657 1.004107950206207 0.6259322466225802 0.9963448483288252 0.010680505612839555 0.0006658011396407539 2.8545701930503344e-05 0.010412338689600066 0.003447118363966877 1.949106372703515e-11 10.710164458564506 -0.37817570358362673 FKGQILMPNIGYGSNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FKGQILMPNIGYGSNK 16 1 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 59242500.0 24544000.0 6443500.0 28255000.0 False True 23764864.15470638 9016423.152408604 20854167.868169397 1.0 0.3794014177279863 0.8775210214715008 24.502326819106926 -10.077494827156594 7.254872438324618 1.0000000753957392 0.6284612195997769 0.42587729845661826 0.20335647667482679 2.480566934598306e-07 3.1544871509442795e-08 0.19689910295228885 0.0656330206254184 8.365755600744423e-11 10.077494827156594 -0.37153885579596235 FKGQILMPNIGYGSNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FKGQILMPNIGYGSNK 16 1 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 55350000.0 17663000.0 12894000.0 24793000.0 False True 24193488.424627237 12324300.445243943 18937404.0278631 1.0 0.5094056809392848 0.7827479731524033 24.528115468670403 -10.137052102982116 5.4153295111987525 1.0000075121073495 0.6460768270457353 0.6909132183029543 0.11159152350786565 1.0121225921978963e-05 1.612687391545891e-06 0.10805032140139482 0.036016009343600525 7.293700013558564e-11 10.137052102982116 -0.3539306850616142 FKGQILMPNIGYGSNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FKGQILMPNIGYGSNK 16 1 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 43144900.0 24544000.0 8263900.0 10337000.0 False True 20409423.483560022 8219380.730444272 12498418.907112146 1.0 0.4027247872564876 0.6123847112673093 24.282732094541203 -10.08662331483748 5.113028307246396 1.0000105253635863 0.5075547492606683 0.8803211656559432 0.08559330556050991 1.026990361036922e-05 1.8344829762163907e-06 0.08287713135461226 0.027625120581272897 8.191749912267817e-11 10.08662331483748 -0.4924557761029179 FKGQILMPNIGYGSNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FKGQILMPNIGYGSNK 16 1 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 56547000.0 11040000.0 25158000.0 20349000.0 False True 14291497.630934456 23757935.18434066 16645690.798372012 1.0 1.6623824736825175 1.1647268346699944 23.768653771093863 -10.264845837799218 5.325024916945051 0.9999496712360615 1.4135546541762951 0.47937289687980733 0.20316706386671082 0.00012140821882380435 1.6761074554856447e-05 0.1967395273680864 0.06557188790444796 5.434432041540174e-11 10.264845837799218 0.4136049829402336 FKGQILMPNIGYGSNKK ddPTM_RPMI8226_Bortezomib_1h_R1 2 FKGQILMPNIGYGSNKK 17 2 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 145760200.0 71806900.0 24552800.0 49400500.0 False True 94139541.2790088 20889617.946064796 44289010.14305696 1.0 0.22190057081489895 0.4704612911995621 26.488297487324623 -10.235464274778069 5.4572950887899685 1.000043970410913 0.34618093101341363 0.9022050659208034 0.10147448917367358 5.4290661916579446e-05 7.605899260623997e-06 0.09825882861105799 0.03275075055285414 5.814812632011842e-11 10.235464274778069 -0.6538630393974993 FKGQILMPNIGYGSNKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FKGQILMPNIGYGSNKK 17 2 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 77965900.0 33477000.0 8821400.0 35667500.0 False True 32414290.959383324 12343831.022993295 26325111.747935984 1.0 0.3808144697183323 0.8121452288104226 24.950126679500332 -9.816403533516281 5.735204322228401 1.0000000657200154 0.5964798492626728 0.5385196439513731 0.17609004503012624 1.480417889924267e-07 3.056616073773452e-08 0.1704984809026371 0.05683281765196461 1.526147348501446e-10 9.816403533516281 -0.4035202164573426 FKGQILMPNIGYGSNKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FKGQILMPNIGYGSNKK 17 2 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 143876900.0 35714800.0 37426100.0 70736000.0 False True 54181962.70162308 30747120.043546062 56754998.595309876 1.0 0.567478889845107 1.0474887908335169 25.691309319261464 -6.669296710550226 1.939716544626224 0.7237593611840025 1.0455490404116152 0.27599626480594064 0.18375489389439745 0.4627358690501483 3.3558504085436125 0.07628087142715392 0.20400155763298838 2.1414270754955168e-07 6.669296710550226 0.3217896792276127 FKGQILMPNIGYGSNKK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FKGQILMPNIGYGSNKK 17 2 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 186820500.0 71806900.0 68896500.0 46117100.0 False True 98355851.43850787 65852424.81974168 35225190.79148819 1.0 0.6695323547772107 0.35814026594554976 26.551507548847514 -7.301384270291856 0.24787688097173088 1.120817701847128 1.2588272024954478e-13 0.9999432939546353 0.0019735187175906038 0.10594315749701863 0.01614294131801125 0.015937430576323533 0.04768784067843203 4.995922925772742e-08 7.301384270291856 -1.120817701847002 down FKGQILMPNIGYGSNKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FKGQILMPNIGYGSNKK 17 2 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 54164900.0 33477000.0 17699200.0 2988700.0 False True 27837608.78255939 17603850.896583863 3613623.3518125215 1.0 0.6323765462072624 0.12981083899981027 24.73053195493461 -7.508530428152529 0.4858786164763148 1.0168169345304945 1.5182613576434138e-19 0.9973834576072415 0.018244651908741416 0.11647667549782806 0.06753737387615734 0.021574185999327204 0.06867192616017362 3.1007701303912446e-08 7.508530428152529 -1.0168169345304945 down FKGQILMPNIGYGSNKK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FKGQILMPNIGYGSNKK 17 2 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 290198500.0 42606500.0 132523000.0 115069000.0 False True 55154954.14967475 125147978.55292058 94127622.70764524 1.0 2.2690251579813627 1.7066032264700977 25.716987142161702 -10.022144877561887 5.207901541242592 0.9999934590938703 1.987814192222397 0.8044222989831399 0.22960779207223542 2.1278901387511946e-05 3.995447358252578e-06 0.22231858214066336 0.07410559623599945 9.502877315205893e-11 10.022144877561887 0.9878207331285268 FKIPEMHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FKIPEMHLK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 10637700.0 2321500.0 2713100.0 5603100.0 False True 3043508.9814379783 2308316.055580966 5023344.960730401 1.0 0.7584390483678964 1.6505109698598628 21.53730419255962 -6.834579171709212 1.3072511154610924 0.8712760958501661 1.676854568450588 0.914742980220659 0.10999975666318197 0.1752234630299902 0.5839755099133515 0.0660331293373958 0.15198346396633355 1.4635947005045283e-07 6.834579171709212 0.8055784726004219 FKIPEMHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FKIPEMHLK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7936400.0 2000400.0 1235000.0 4701000.0 False True 1936898.3969636015 1728141.9404399185 3469667.0730229807 1.0 0.8922212663034147 1.791352132079948 20.885316846424203 -6.876966984665766 1.096639195018624 0.9355471713164463 1.8514640890455094 0.9711525577387901 0.06808637412945084 0.130347566170286 0.2888462313283464 0.04795186704695549 0.1151114154443321 1.327495370910377e-07 6.876966984665766 0.9159169177290631 FKIPEMHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FKIPEMHLK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 11300700.0 2321500.0 2896600.0 6082600.0 False True 3179821.2861785684 2768618.634224723 4646015.155079263 1.0 0.8706837224654161 1.461093167491413 21.600514254082512 -6.8493010649131 1.2383944674130818 0.9310292110026585 1.4843875000461229 0.9392911815162522 0.06243610989563292 0.15822713791445542 0.46730250040378524 0.03945749236043118 0.0912707345277218 1.4148126527714124e-07 6.8493010649131 0.5533582890434644 FKIPEMHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FKIPEMHLK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5433080.0 2000400.0 2589600.0 843080.0 False True 1663421.232745822 2575649.3108046483 1019364.1300385114 1.0 1.548404733630221 0.6128117821099586 20.66572212185848 -6.74786132014099 1.6580071523636328 1.323296434220832 0.6112785105933425 0.6396314754691204 0.2304217032825073 0.3037822238207352 1.6424134225857112 0.10982189712345389 0.26719349091760536 1.7870581310427232e-07 6.74786132014099 -0.7120179236274895 FKMPDLHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FKMPDLHLK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7101200.0 1815600.0 2345300.0 2940300.0 False True 2380269.182295409 1995390.3819077983 2636065.9613491814 1.0 0.8383045063766892 1.107465483717726 21.18269330504349 -6.744050536652913 1.6721481901402615 0.9042452737274482 1.1077582659405367 0.62288862258821 0.06793441394782243 0.31052548902420873 1.706338494836741 0.03212253172616844 0.07846949369825738 1.8028079450084372e-07 6.744050536652913 0.2035129922130885 FKMPDLHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FKMPDLHLK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7331900.0 1815600.0 3863500.0 1652800.0 False True 2486876.3847451247 3692797.7951139994 1262442.6804844984 1.0 1.4849140945509711 0.5076419110449206 21.24590336656638 -6.7717709476821435 1.5676818449968764 1.2774889477027693 0.5017685827845021 0.7373629863236353 0.20446645980256567 0.26353366527626176 1.278435748567951 0.10279136316935582 0.24429002640667716 1.6913327263921737e-07 6.7717709476821435 -0.7757203649182672 FKMPDMHFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FKMPDMHFK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7968800.0 2127300.0 939900.0 4901600.0 False True 2788910.9008025066 799670.583701505 4394429.451467251 1.0 0.2867322091470905 1.5756793987942599 21.411270413685497 -6.756496979921808 1.6255820197817852 0.5838823374435472 1.579596871086255 0.6764750422414245 0.2998724643506728 0.28887342409040273 1.5036375109992872 0.1456040779628295 0.3511409139055604 1.7518746166795594e-07 6.756496979921808 0.9957145336427077 FKMPDMHFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FKMPDMHFK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7403000.0 2127300.0 3565300.0 1710400.0 False True 2913820.298120903 3407773.2571295346 1306438.746793736 1.0 1.1695207351418266 0.4483594089986424 21.474480475208388 -6.84475970973835 1.2602036271508408 1.0902019984982185 0.42233033692643485 0.9323138214003172 0.08010015672096167 0.16331661018681876 0.5017655101493455 0.049798192743599944 0.11490862562471815 1.4296847682511535e-07 6.84475970973835 -0.6678716615717837 down FKMPDMHFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FKMPDMHFK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7305200.0 1720400.0 2548700.0 3036100.0 False True 2227091.7141539557 2406862.604512638 2483560.953016726 1.0 1.0807200211900456 1.1151588132777908 21.08672954048562 -13.999999999753957 0.11635603506873607 0.6139973255842387 1.1729243389856183 0.9997109795591603 0.0008204689440846297 11.97918134139953 0.10449155868729629 1.0747670981853967 0.051258983565321076 1.0000000005665354e-14 13.999999999753957 0.5589270134013796 FKMPDVHFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FKMPDVHFK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 4888600.0 1301300.0 2131700.0 1455600.0 False True 1782425.776310219 2037514.4454107718 1111817.259023012 1.0 1.14311320700748 0.623766371536981 20.765410570605574 -6.833217005815487 1.313336325463268 1.0763203054750785 0.6088368781705246 0.912172876290914 0.06490996781621071 0.17688123341797915 0.5955156348826137 0.03879017597369147 0.08927555414981747 1.468192476198468e-07 6.833217005815487 -0.46748342730455394 FKMPEMHFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FKMPEMHFK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 46862500.0 10236000.0 7924500.0 28702000.0 False True 13419495.12556501 6742195.48945907 25732192.36902502 1.0 0.5024179692583777 1.9175231354273177 23.677827059032406 -6.811687446758739 1.4074418335449737 0.7293605890533191 1.9432450200874942 0.8641885998360956 0.21600496642037603 0.20450565527505832 0.7981012853812393 0.12066659237403735 0.27891756392588146 1.5428103839506864e-07 6.811687446758739 1.2138844310341752 FKMPEMHFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FKMPEMHFK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 24419800.0 4779900.0 2572900.0 17067000.0 False True 4628164.69088498 3600272.3874962456 12596640.700974926 1.0 0.7779049856602693 2.721735621418918 22.142008772251767 -6.878475713349852 1.0882310820560748 0.8649268568222954 2.855547876732584 0.9724364819690575 0.1442283300878988 0.12899047698791558 0.2804990368853832 0.10222808547983278 0.24629122491614805 1.3228916847942102e-07 6.878475713349852 1.9906210199102885 up FKMPEMHFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FKMPEMHFK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 34155600.0 10316000.0 16349000.0 7490600.0 False True 15650126.200621169 13431393.214679958 6010079.626753392 1.0 0.8582290674529419 0.38402755030274743 23.8996709551251 -6.9489823538791935 0.5699055750223223 1.0059095896796182 0.21329540470418606 0.9991189901028961 0.00781801215716423 0.0838969578096156 0.037673392182767426 0.008283597200307741 0.0395093924773642 1.1246506695012445e-07 6.9489823538791935 -0.7926141849754321 down FKMPEMHFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FKMPEMHFK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 37597000.0 10236000.0 17345000.0 10016000.0 False True 14020525.817498965 16578640.547755254 7650427.085995124 1.0 1.182454978048221 0.5456590705354756 23.741037120555298 -6.830109537243348 1.327451819278992 1.0974831417485562 0.5284884448995738 0.9060907026028636 0.08205186823291657 0.18067383139686644 0.6226168589300338 0.048532008424290035 0.11168368911998171 1.4787353762327708e-07 6.830109537243348 -0.5689946968489824 FKMPEMHFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FKMPEMHFK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 18749100.0 4779900.0 8910600.0 5058600.0 False True 3974698.6354737813 8862596.829184378 6116329.871676263 1.0 2.229753156651073 1.5388160040835903 21.922414047686043 -10.301706621729009 5.304506803903232 0.9998252206676862 1.8842845803673953 0.6859262328824316 0.28207391135386706 0.0005831545456559918 7.676722205990217e-05 0.2731696081955069 0.09103896342272738 4.992216119720463e-11 10.301706621729009 0.8844593596997091 FKMPEMHFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FKMPEMHFK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 29558100.0 10316000.0 9195100.0 10047000.0 False True 13354265.358760884 8683384.601857482 8218549.09092554 1.0 0.6502330430449973 0.61542502489917 23.67079727721755 -13.999999999999998 0.3261811012726946 4.721065688988403 0.608981474552509 0.9997068599740255 0.0029734288986228087 18.50567071396781 0.18243071060876567 47.14622998597374 0.011315860083047953 1.0000000000000041e-14 13.999999999999998 -4.112084214435893 FKMPEMHFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FKMPEMHFR 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 6125100.0 2191500.0 1002800.0 2930800.0 False True 2873077.7225161907 853186.1488837847 2627548.9302187483 1.0 0.296958951787973 0.9145415418548397 21.454165590517615 -10.59433527405721 9.177794077412987 1.0000745871668326 0.60575024682149 0.35206505001093025 0.25212703661504304 0.0003848618341750539 1.7011309875061656e-05 0.24416653186739135 0.08137365116155737 2.5448648658868485e-11 10.59433527405721 -0.3943243403453426 FKMPEMHFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FKMPEMHFR 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 6339800.0 2191500.0 2431700.0 1716600.0 False True 3001756.773060668 2324259.453443437 1311174.4344867424 1.0 0.7742997281800292 0.4368023572908725 21.517375652040506 -6.965308926204448 0.35270988747915005 1.031614777850864 0.16805137624207364 0.9999193724588632 0.0020780635133753242 0.07785628481077984 0.014491163843085466 0.004601735899681961 0.028957449100849016 1.083156159673236e-07 6.965308926204448 -0.8635634016087903 down FKMPEMHFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FKMPEMHFR 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7432700.0 1315400.0 3798800.0 2318500.0 False True 1702811.230410434 3587393.4405864184 1896556.7898189356 1.0 2.106747581011512 1.1137798224186026 20.699487079475396 -6.620131951111651 2.1158912104376477 1.7342727805951144 1.1175441011232903 0.08333707320204697 0.475919494830796 0.5850671353984237 4.977348428017769 0.1847888488698548 0.5278105128044701 2.3981041955308293e-07 6.620131951111651 -0.6167286794718241 FKMPEMNIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FKMPEMNIK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 6637900.0 1623800.0 2182800.0 2831300.0 False True 2128817.524901566 1857134.7484877585 2538344.2357473546 1.0 0.8723785513620431 1.1923728577275428 21.02162086143379 -6.79846892495064 1.462064720950719 0.9294481214969533 1.196629526522662 0.8276745867926005 0.054599043105808806 0.22294995139357301 0.9410338922355423 0.029379884249979015 0.0683942576411952 1.590490484029842e-07 6.79846892495064 0.26718140502570875 FKMPEMNIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FKMPEMNIK 9 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 8846200.0 1623800.0 3406900.0 3815500.0 False True 2224162.7415450164 3256371.892888285 2914357.4826891306 1.0 1.4640888600742605 1.3103166545558935 21.08483092295668 -10.110614140616379 4.759081899466375 0.9999773392441637 1.3872027573192278 0.8942241626240718 0.06277724003799716 1.5094966849853654e-05 2.820874695628134e-06 0.060787354508491105 0.020261267096977946 7.751501927892428e-11 10.110614140616379 0.38722541807506417 FKMPFLSISSPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FKMPFLSISSPK 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 13840300.0 5675800.0 3158600.0 5005900.0 False True 7441028.764525395 2687349.1921263654 4487937.487983494 1.0 0.3611529100570236 0.6031340060637091 22.827070665237482 -10.253502018131144 5.567414190632971 1.0000361531388735 0.4821434580603908 0.8592844304930126 0.09878836876936141 4.433411708722636e-05 5.94437190930922e-06 0.09565808370635001 0.031883808920219074 5.578250099677148e-11 10.253502018131144 -0.5178926950784828 FKMPFLSISSPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FKMPFLSISSPK 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 8887300.0 3416600.0 1351400.0 4119300.0 False True 3308141.903152283 1891021.0674578988 3040331.7536489125 1.0 0.5716263457912645 0.9190451445724932 21.657589689741226 -9.937663301765463 6.703423281399766 1.000000019260848 0.745335745181876 0.41739223053456476 0.1418331306774561 4.0875185533616976e-08 6.410710387941587e-09 0.13732934849537842 0.045776446087852425 1.1543478495692948e-10 9.937663301765463 -0.2546642740789721 FKMPFLSISSPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FKMPFLSISSPK 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 12180400.0 3206800.0 0.0 8973600.0 False True 4864950.0484831305 0.0 7199964.026731405 1.0 0.0 1.4799666913283769 22.213993561344818 -6.7247018059808275 1.7425169455807694 0.3946933557117691 1.4782828046110907 0.5346025719966332 0.4205777449133271 0.34623453155289247 2.0569938423910554 0.19146857326074113 0.4779983958137198 1.8849428792896586e-07 6.7247018059808275 1.0835894488993216 FKMPFLSISSPK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FKMPFLSISSPK 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 26131000.0 6810500.0 11399400.0 7921100.0 False True 9328525.896842193 10895736.815225195 6050299.320175303 1.0 1.1680019904231085 0.648580428149253 23.15321769227293 -6.819640998605806 1.3734445363164736 1.0905872872559785 0.6373306643455459 0.8835376720742378 0.0738550385449636 0.19395932465002824 0.7190249690854107 0.04225759097128136 0.09740554725068222 1.514812922741304e-07 6.819640998605806 -0.45325662291043267 FKMPFLSISSPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FKMPFLSISSPK 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7259900.0 3416600.0 1774800.0 2068500.0 False True 2841054.281043473 1765238.800129781 2501013.786336601 1.0 0.6213323032608294 0.8803118627561101 21.437994965175502 -10.100679754788345 5.297225563358315 1.000004291482624 0.7508220830082531 0.5524360206318827 0.10572796242979063 5.358655251720528e-06 9.095843625324316e-07 0.10237242181320194 0.03412355314314251 7.930859300160233e-11 10.100679754788345 -0.24918220847437078 FKMPFLSISSPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FKMPFLSISSPK 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 28130800.0 3206800.0 14359000.0 10565000.0 False True 4151265.815478326 13559909.02742458 8642278.40605437 1.0 3.266451639127848 2.081841729775758 21.985119883437267 -10.130402693559194 10.677905774160195 0.9999999874772126 2.674146684451808 0.7270014918473858 0.48361497035954254 1.033165852091765e-08 1.306921221056923e-09 0.46825818503357064 0.1560860605149251 7.406231901983482e-11 10.130402693559194 1.6741466969745953 FKPGYLEATLNWFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FKPGYLEATLNWFR 14 1 D6R967;H0Y9D8;Q9H2U2-4;Q9H2U2-6;Q9H2U2-3;Q9H2U2;Q9H2U2-2 D6R967 PPA2 Inorganic pyrophosphatase 2, mitochondrial 0 7031700.0 2943500.0 2174200.0 1914000.0 False True 2850060.2036904413 3042369.3983032173 1412665.981230797 1.0 1.0674754850314254 0.49566180370561513 21.44256096391674 -6.877463425371087 1.0937937082872267 1.0405739055098862 0.4570498771595074 0.9715835959745994 0.043009852188382096 0.1299033139939499 0.2860349703597472 0.030355197346569246 0.07295951342718103 1.325978781946612e-07 6.877463425371087 -0.5835240283503788 down FKPGYLEATLNWFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FKPGYLEATLNWFR 14 1 D6R967;H0Y9D8;Q9H2U2-4;Q9H2U2-6;Q9H2U2-3;Q9H2U2;Q9H2U2-2 D6R967 PPA2 Inorganic pyrophosphatase 2, mitochondrial 0 8719300.0 2943500.0 3230800.0 2545000.0 False True 2447650.669159831 3213395.0391364065 3077147.7332495335 1.0 1.3128487163731666 1.2571841938154438 21.222966239351017 -10.047889960170403 4.339753591316959 0.9999793281991544 1.285016455135736 0.9721882215632236 0.02272494632547601 7868456.09026936 0.15612124689431298 1653.9387239367013 0.007779353552893492 8.955916582996209e-11 10.047889960170403 0.28503712693658156 FKPLSDK(ub)IQQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FKPLSDKIQQQR 12 2 P35249;C9JZI1;P35249-2;C9J8M3 P35249 RFC4 Replication factor C subunit 4 1 10262600.0 3646100.0 5432400.0 1184100.0 True False 4780072.408882624 4621907.095329347 1061580.6906892397 1.0 0.9669115235034172 0.22208464639919373 22.188601041744562 -6.9162043221392295 0.8524119230399342 1.0187885810078081 0.11187253181606512 0.9930595809464283 0.02992198174969038 0.10045740287715035 0.11757124692954954 0.025275289308882384 0.07316865200385758 1.212818122755445e-07 6.9162043221392295 -0.906916049191743 down FKPLSDK(ub)IQQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FKPLSDKIQQQR 12 2 P35249;C9JZI1;P35249-2;C9J8M3 P35249 RFC4 Replication factor C subunit 4 1 16013700.0 5929500.0 5670200.0 4414000.0 True False 5741271.268144199 7934340.429702369 3257840.9828384216 1.0 1.3819831983425954 0.567442440999915 22.45293879214476 -6.779184707925673 1.539084757744907 1.2165160228533125 0.561157910441656 0.7644904154200086 0.16148059830648515 0.25183854114428267 1.1782554057161478 0.08264268644916004 0.19513229836274615 1.6627053418833814e-07 6.779184707925673 -0.6553581124116565 FKPLSDK(ub)IQQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FKPLSDKIQQQR 12 2 P35249;C9JZI1;P35249-2;C9J8M3 P35249 RFC4 Replication factor C subunit 4 1 8620700.0 3646100.0 3576300.0 1398300.0 True False 4994161.702147609 3418287.2407574 1068050.3388924685 1.0 0.6844566605217158 0.21385978320108887 22.251811103267453 -7.273438768167943 0.4275559816651639 1.024020856826145 2.997996863575418e-15 0.9993741328639648 0.008080961116921354 0.09802974478418357 0.034032266875147786 0.01143154416928004 0.051105848092162565 5.3279633878456404e-08 7.273438768167943 -1.024020856826142 down FKPLSDK(ub)IQQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FKPLSDKIQQQR 12 2 P35249;C9JZI1;P35249-2;C9J8M3 P35249 RFC4 Replication factor C subunit 4 1 20584600.0 5929500.0 13458000.0 1197100.0 True False 4930641.97138889 13385499.08279616 1447408.075234976 1.0 2.7147578673260795 0.29355367589735215 22.233344067579036 -6.716492792818956 1.7721395783695553 2.047167022191084 0.2981273377172559 0.49575001526022755 0.7219093039238982 0.3622180252851715 2.2212012769860277 0.3237112459157846 0.8159449137782928 1.92091083928648e-07 6.716492792818956 -1.749039684473828 FKVEYHAGGSTQNSIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FKVEYHAGGSTQNSIK 16 1 P55263;A0A5K1VW54;P55263-3;P55263-4;P55263-2;A0A5F9ZH31;A0A5K1VW94;A0A5F9ZH72;A0A5F9ZH83 P55263 ADK Adenosine kinase 0 11658500.0 4601600.0 3389700.0 3667200.0 False True 6032742.161957788 2883969.9729471104 3287753.3222663463 1.0 0.47805291449936327 0.5449848897900489 22.524382492544895 -10.42638687624209 5.990415838808444 1.0001789231852896 0.5115189021450506 0.9861145358530363 0.027324864489792513 6.531903375709222e-05 6.254599784669949e-06 0.026466714910729005 0.008819062092194978 3.746391192312063e-11 10.42638687624209 -0.488660021040239 FKVEYHAGGSTQNSIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FKVEYHAGGSTQNSIK 16 1 P55263;A0A5K1VW54;P55263-3;P55263-4;P55263-2;A0A5F9ZH31;A0A5K1VW94;A0A5F9ZH72;A0A5F9ZH83 P55263 ADK Adenosine kinase 0 10910500.0 2466900.0 1709200.0 6734400.0 False True 2388589.609812789 2391692.4733602526 4970458.612330549 1.0 1.0012990358556013 2.0809177901096705 21.187727570984716 -6.907157747453997 0.9148498636125934 0.9634938898996055 2.212289835557886 0.9898045281895075 0.05141966713541355 0.10632855625911417 0.14917591407587452 0.04151501688377217 0.11246744285858572 1.238346703951559e-07 6.907157747453997 1.2487959456582807 up FKVEYHAGGSTQNSIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FKVEYHAGGSTQNSIK 16 1 P55263;A0A5K1VW54;P55263-3;P55263-4;P55263-2;A0A5F9ZH31;A0A5K1VW94;A0A5F9ZH72;A0A5F9ZH83 P55263 ADK Adenosine kinase 0 9797100.0 4601600.0 2589600.0 2605900.0 False True 6302935.873564206 2475182.9093379667 1990440.0901951538 1.0 0.3927031718217834 0.31579570697259735 22.587592554067786 -13.999999999999998 0.2913688159050661 6.2736360876379615 0.29512570421464757 0.9996305262544226 0.005882310905092889 16.047609520722585 0.17120664822213966 50.767632379404475 0.02886759004019263 1.0000000000000041e-14 13.999999999999998 -5.978510383423314 FKVEYHAGGSTQNSIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FKVEYHAGGSTQNSIK 16 1 P55263;A0A5K1VW54;P55263-3;P55263-4;P55263-2;A0A5F9ZH31;A0A5K1VW94;A0A5F9ZH72;A0A5F9ZH83 P55263 ADK Adenosine kinase 0 6558700.0 2466900.0 2779000.0 1312800.0 False True 2051336.6521998919 2764028.975411687 1587300.41029862 1.0 1.3474282597385907 0.773788353362852 20.968132846418992 -6.74273721722393 1.676464479908296 1.206064054986142 0.7732353645392809 0.6171897898868512 0.1459700390418298 0.31291965528369803 1.7278193272450024 0.06884907652312282 0.16845823462247583 1.808267941283472e-07 6.74273721722393 -0.43282869044686123 FKWWGLQSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FKWWGLQSK 9 1 P48739;P48739-2;P48739-3;A0A0A0MSW4 P48739 PITPNB Phosphatidylinositol transfer protein beta isoform 0 6073500.0 1873200.0 1038100.0 3162200.0 False True 2455783.340094604 883219.5264821057 2835005.877964285 1.0 0.3596487980279569 1.154420193214224 21.227751854804662 -6.69226905081874 1.8582595857287267 0.5993941544835728 1.1517561877225908 0.3810655708945291 0.27070069721230233 0.4118339111263903 2.758940229694121 0.11645893271985583 0.30241309715951287 2.0310983304819316e-07 6.69226905081874 0.552362033239018 FKWWGLQSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FKWWGLQSK 9 1 P48739;P48739-2;P48739-3;A0A0A0MSW4 P48739 PITPNB Phosphatidylinositol transfer protein beta isoform 0 7253600.0 1873200.0 1214700.0 4165700.0 False True 2565772.661326598 1161030.5375242603 3181847.4552845336 1.0 0.45250717455379125 1.240112775088734 21.290961916327554 -6.719797950793968 1.7604775904546222 0.6668331978990862 1.2388351367026338 0.5113899756435093 0.23039248996032172 0.3556985871576306 2.1544521120172795 0.1039264623911288 0.26091342763835773 1.9063474121585907e-07 6.719797950793968 0.5720019388035475 FLAAGTHLGGTNLDFQMEQYIYK ddPTM_RPMI8226_Bortezomib_2h_R1 2 FLAAGTHLGGTNLDFQMEQYIYK 23 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 47617700.0 29922000.0 7427300.0 10268400.0 False True 28972142.488474738 10393059.622857817 7578797.99460309 1.0 0.35872595984201816 0.26158914542195055 24.788163039990263 -13.999999999999998 0.26572813716806104 5.838013351665764 0.2279870600264378 0.9995742281104981 0.006759854241779515 14.678088985146857 0.1631516661598393 38.26408439805762 0.041223328014838245 1.0000000000000041e-14 13.999999999999998 -5.610026291639326 FLAAGTHLGGTNLDFQMEQYIYK ddPTM_RPMI8226_Bortezomib_8h_R1 2 FLAAGTHLGGTNLDFQMEQYIYK 23 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 1330116000.0 444736000.0 524500000.0 360880000.0 False True 674697026.5567513 430898877.0627951 289551909.8206773 1.0 0.6386553669309089 0.4291584198886669 29.329664562878452 -9.62545450438342 0.126033540946777 1.6706414625706194 2.3481084405139535e-10 0.9998745643297827 0.0026406554776992864 1.0982002013254304 0.0519160448492701 0.4673237083973194 0.21636279052830432 2.368893278191495e-10 9.62545450438342 -1.6706414623358086 FLAAGTHLGGTNLDFQMEQYIYK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FLAAGTHLGGTNLDFQMEQYIYK 23 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 52299700.0 29922000.0 11100200.0 11277500.0 False True 24881468.769356366 11040401.019382821 13635573.108731478 1.0 0.44371982706181756 0.5480212295796959 24.56856831542454 -9.922585696523038 5.763893636553193 1.000000310771111 0.49587052832049233 0.9688947291829009 0.042580869272612724 1.7001861654684094e-07 3.1762970319925166e-08 0.04122877457710857 0.0137429164630733 1.1951276755856186e-10 9.922585696523038 -0.5041297824506188 FLAAGTHLGGTNLDFQMEQYIYK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FLAAGTHLGGTNLDFQMEQYIYK 23 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 959722600.0 444736000.0 244219400.0 270767200.0 False True 575719519.0571803 230628375.70389372 221490347.9060866 1.0 0.4005915520835203 0.3847191915063214 29.100790884970902 FLALYLHGAA ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLALYLHGAA 10 0 Q9BZE1;A6NHR2 Q9BZE1 MRPL37 39S ribosomal protein L37, mitochondrial 0 29385700.0 9054500.0 10990000.0 9341200.0 False True 13736338.472617693 9028748.63473808 7494907.725606595 1.0 0.6572893244248588 0.5456263137769284 23.711494158078228 -13.999999999999998 0.15680653438863287 2.6769139520427134 0.4318942384082984 0.9995451343492459 0.004123172843619233 11.989911461177163 0.12502237982227216 6.117204987141059 0.10325703887654275 1.0000000000000041e-14 13.999999999999998 -2.245019713634415 FLALYLHGAA ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLALYLHGAA 10 0 Q9BZE1;A6NHR2 Q9BZE1 MRPL37 39S ribosomal protein L37, mitochondrial 0 26436300.0 9054500.0 9431500.0 7950300.0 False True 11721228.74087827 8906628.734045185 6503426.976966794 1.0 0.7598715911910284 0.5548417423410418 23.482620480170677 -6.972961537473699 0.17342585071411132 1.173004100081528 0.13620052201768504 0.9999972225970044 0.0003031300590342339 0.07535294038842036 0.005429609817522977 0.008374402754520626 0.023488275296286457 1.0642372663509117e-07 6.972961537473699 -1.036803578063843 FLASVLHNGLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLASVLHNGLGR 12 0 H0Y6Y8;B1AL05;Q8N983-4;Q8N983-3;Q8N983-2;Q8N983;Q8N983-6;Q8N983-7;M0R051 H0Y6Y8 MRPL43 39S ribosomal protein L43, mitochondrial 0 11492500.0 3148100.0 3890200.0 4454200.0 False True 4127189.5862437636 3309797.323880833 3993322.1117034084 1.0 0.801949427017513 0.967564495949848 21.976728280712862 -10.078959865224556 5.841384168557827 1.0000004802478473 0.8847569615171597 0.3923216081291354 0.06761206876671433 4.2286323719922115e-07 6.663320847694252e-08 0.06546537722398668 0.021821701361338007 8.337582317722968e-11 10.078959865224556 -0.11524351873068761 FLASVLHNGLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLASVLHNGLGR 12 0 H0Y6Y8;B1AL05;Q8N983-4;Q8N983-3;Q8N983-2;Q8N983;Q8N983-6;Q8N983-7;M0R051 H0Y6Y8 MRPL43 39S ribosomal protein L43, mitochondrial 0 12377700.0 6873300.0 1349200.0 4155200.0 False True 6655110.853754201 1887942.5959850517 3066828.4666719995 1.0 0.2836831177530346 0.46082304773961463 22.666031266540152 -10.688402699883566 10.143564352390241 1.0004335880686428 0.3722530827540734 0.9436448511982038 0.07231707358990967 0.0007095224799886804 2.1795654990197602e-05 0.07006187820582026 0.023340235138348042 2.0492611186751707e-11 10.688402699883566 -0.6281805053145694 FLASVLHNGLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLASVLHNGLGR 12 0 H0Y6Y8;B1AL05;Q8N983-4;Q8N983-3;Q8N983-2;Q8N983;Q8N983-6;Q8N983-7;M0R051 H0Y6Y8 MRPL43 39S ribosomal protein L43, mitochondrial 0 11258500.0 3148100.0 4046500.0 4063900.0 False True 4312037.644203639 3867712.250013927 3104090.518647721 1.0 0.8969569769904523 0.7198662847529465 22.039938342235754 -6.962898172615128 0.39245781950230196 1.0105828122608902 0.5998522761149075 0.9998630460515908 0.0013538559746016346 0.07868162726854791 0.017421437861158323 0.0022835885092615665 0.014881246293896236 1.0891854405885739e-07 6.962898172615128 -0.41073053614598265 FLASVLHNGLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLASVLHNGLGR 12 0 H0Y6Y8;B1AL05;Q8N983-4;Q8N983-3;Q8N983-2;Q8N983;Q8N983-6;Q8N983-7;M0R051 H0Y6Y8 MRPL43 39S ribosomal protein L43, mitochondrial 0 9718600.0 6873300.0 1617300.0 1228000.0 False True 5715453.488818158 1608587.283891085 1484769.1223695192 1.0 0.28144525837506357 0.25978150732472144 22.44643654197443 FLASVSTVLTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLASVSTVLTSK 12 0 G3V1N2;P69905 G3V1N2;P69905 HBA2;HBA1 Hemoglobin subunit alpha 0 9836200.0 4118000.0 3297600.0 2420600.0 False True 5398737.878768734 2805610.9339441243 2170139.5320347706 1.0 0.5196790429440126 0.4019716424035213 22.364190741625215 -13.999999999999998 0.19750937300129023 3.645144727231015 0.3236234071824852 0.9994869979902514 0.005858802597152886 12.482736516265295 0.1409271076746424 12.74258694130599 0.07636596110895047 1.0000000000000041e-14 13.999999999999998 -3.32152132004853 FLASVSTVLTSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLASVSTVLTSK 12 0 G3V1N2;P69905 G3V1N2;P69905 HBA2;HBA1 Hemoglobin subunit alpha 0 22809300.0 10990000.0 5083800.0 6735500.0 False True 10641128.465621855 7113787.851666776 4971270.489331268 1.0 0.6685181815677906 0.4671751220175456 23.343147817440585 -9.269924311885042 0.11918711484033082 1.6216760684247247 2.9856319050995e-13 0.9999175193140946 0.0019950728576620036 0.716577753757259 0.04297624725234572 0.35615066608790286 0.20832081706936695 5.371253975284033e-10 9.269924311885042 -1.621676068424426 FLASVSTVLTSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLASVSTVLTSK 12 0 G3V1N2;P69905 G3V1N2;P69905 HBA2;HBA1 Hemoglobin subunit alpha 0 19403900.0 3653100.0 7918900.0 7831900.0 False True 5542019.777383589 6505710.424351903 6283921.532156282 1.0 1.1738879841066312 1.1338684783840574 22.401980428588526 -10.09027297591196 4.3555006993935095 0.9999836140323431 1.1538782312600155 0.9517208120785333 0.016337894847481247 1784463.13727392 4134018.490735762 155.0199048881106 0.005592896179708565 8.123197718583058e-11 10.09027297591196 0.1538946172276724 FLASVSTVLTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLASVSTVLTSK 12 0 G3V1N2;P69905 G3V1N2;P69905 HBA2;HBA1 Hemoglobin subunit alpha 0 12702600.0 4118000.0 3085200.0 5499400.0 False True 5640535.88476561 2948885.662607928 4200554.983698237 1.0 0.5228023937534912 0.7447084939293475 22.427400803148107 -10.08728836155712 5.188080810668539 1.0000067382860027 0.633755443840784 0.7841092759750506 0.09059278604251259 7.060926622157778e-06 1.2422230258020137e-06 0.08771770092068172 0.029238695968779684 8.179215266979991e-11 10.08728836155712 -0.36625129444521876 FLASVSTVLTSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLASVSTVLTSK 12 0 G3V1N2;P69905 G3V1N2;P69905 HBA2;HBA1 Hemoglobin subunit alpha 0 15810900.0 10990000.0 2385600.0 2435300.0 False True 9138671.939550374 2372748.2992954766 2944509.97044502 1.0 0.2596381963364599 0.322203268693973 23.12355309287486 -10.413839996897785 7.0029799265209425 1.0000556962079792 0.29092073260453544 0.9941949340368289 0.0255420838327026 2.2212784791217272e-05 1.8592133439951904e-06 0.024732938580720357 0.008243672109290912 3.8562040205893774e-11 10.413839996897785 -0.7091349636034437 FLASVSTVLTSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLASVSTVLTSK 12 0 G3V1N2;P69905 G3V1N2;P69905 HBA2;HBA1 Hemoglobin subunit alpha 0 17934000.0 3653100.0 8435500.0 5845400.0 False True 4729009.9633665485 7966057.009599556 4781597.178868934 1.0 1.6845084005550661 1.011120132101593 22.173106750680976 -10.523285182878823 5.171316037911832 0.9988084721761845 1.347814266328299 0.26238195346306037 0.274909609414564 0.0037887373891968843 0.0003492623756726282 0.2670379154353637 0.08872669491458081 2.997193741866681e-11 10.523285182878823 0.3490057941521145 FLATTPNSLLVSWQPPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLATTPNSLLVSWQPPR 17 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1;H0Y4K8 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 16581200.0 3835700.0 6982100.0 5763400.0 False True 5028639.844971642 5940397.896012633 5167058.654436581 1.0 1.1813130546528796 1.0275260932841213 22.2617367995196 -10.733815633634935 2.919593030336987 0.9825746723943133 1.1044195738653206 0.3806900633418756 0.06278326523207516 21244162.830820423 14790855.530836811 2637309.37698707 0.024817265353241365 1.8457988300048337e-11 10.733815633634935 0.12184490147100735 FLATTPNSLLVSWQPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLATTPNSLLVSWQPPR 17 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1;H0Y4K8 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 27537700.0 13535000.0 8304200.0 5698500.0 False True 13105338.833684433 11620110.365830904 4205891.8986644205 1.0 0.8866699681174155 0.32092965714507793 23.64365131870632 -6.939841074688539 0.661040165917332 1.006367832956584 0.16907801811027648 0.998143012533649 0.012799853939852241 0.08783920499020666 0.05494035062577737 0.012444745231630494 0.048726329248289735 1.1485738526307131e-07 6.939841074688539 -0.8372898148463075 down FLATTPNSLLVSWQPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLATTPNSLLVSWQPPR 17 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1;H0Y4K8 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 26469700.0 3835700.0 10960000.0 11674000.0 False True 5253861.945894959 10475750.960126692 8916841.633576984 1.0 1.99391439440311 1.6971975520871934 22.32494686104249 -9.962327228671901 5.416462082496452 0.9999979740573881 1.845555973247462 0.915453215999785 0.12113414363542184 2.9636054624814294e-06 5.675766777042281e-07 0.11728791154205423 0.03909587674524959 1.0906182766046505e-10 9.962327228671901 0.8455579991900739 FLAVGLVDNTVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLAVGLVDNTVR 12 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 21603700.0 7464500.0 7706800.0 6432400.0 False True 9786031.786320828 6556975.480871111 5766836.951937732 1.0 0.670034149085498 0.5892926855192488 23.222292538166347 -13.999999999998629 0.1977196090703259 2.8185565426478103 0.5356613829869055 0.9994869780190097 0.004024059859458709 12.48670378035056 0.14100134048788193 8.773473684173883 0.05229995631506732 1.0000000000031577e-14 13.999999999998629 -2.282895159660905 FLAVGLVDNTVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLAVGLVDNTVR 12 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 17562700.0 7892600.0 3194200.0 6475900.0 False True 7642053.733190822 4469660.717532945 4779667.517164326 1.0 0.5848769026734789 0.6254428042563173 22.865528971004863 -9.950687420710668 7.113298861910806 1.0000000135626577 0.6051598539638374 0.9921455395549267 0.016560959972321206 3.5538567341564863e-09 5.37452652094818e-10 0.01603508102038283 0.0053450268475003304 1.1202438781692852e-10 9.950687420710668 -0.39484015959882024 FLAVGLVDNTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLAVGLVDNTVR 12 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 34332000.0 6107200.0 19271000.0 8953800.0 False True 9265068.896125771 15831939.484989755 7184077.505410045 1.0 1.7087773078093298 0.7753938568567038 23.14337027366408 -6.703704041755258 1.8178791213648549 1.4385301235852523 0.7779933269168308 0.4350182033410872 0.2989879536447171 0.3878963689342542 2.4946830737654264 0.13109170310854962 0.3355730387822031 1.9783173428762429e-07 6.703704041755258 -0.6605367966684216 FLAVGLVDNTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLAVGLVDNTVR 12 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 32248500.0 7464500.0 10857000.0 13927000.0 False True 10224327.370527647 10377301.840702137 10637729.435568493 1.0 1.0149618126093507 1.0404331796175175 23.285502599689238 -6.963070235493214 0.3897837892446793 0.998431865578209 1.057877977953747 0.9998675073437719 0.00019204277206131211 0.07862234644123324 0.01721011577951994 0.0003289037953109992 0.0021427939195207096 1.0887540023139031e-07 6.963070235493214 0.059446112375538096 FLAVGLVDNTVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLAVGLVDNTVR 12 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 15432300.0 7892600.0 3639500.0 3900200.0 False True 6563046.601464545 3619893.2911158134 4715713.787512704 1.0 0.5515568471368211 0.7185251109538657 22.64593424643914 -10.064272455797347 4.956361188346525 1.0000084031171836 0.6350409790428169 0.8643200942386198 0.06816450827377556 6.32958977339289e-06 1.1949833516227184e-06 0.06600152019988369 0.022000000444312672 8.624373256679995e-11 10.064272455797347 -0.3649674240743668 FLAVGLVDNTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLAVGLVDNTVR 12 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 29055200.0 6107200.0 14618000.0 8330000.0 False True 7905890.790909689 13804495.449745256 6814025.4730177885 1.0 1.746102471541584 0.8618921830861433 22.91449659575653 -6.6830342786888455 1.891403760825532 1.4707806630094042 0.8651968193847617 0.3379689827070337 0.3160087516281176 0.4317964313864376 2.9891813028974155 0.13394583334815674 0.351867439300784 2.0747497518282734e-07 6.6830342786888455 -0.6055838436246426 FLCFGSEGGTYYIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLCFGSEGGTYYIK 14 0 P10155-3;P10155-5;P10155-4;P10155;P10155-2 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 0 8861400.0 2974900.0 4154900.0 1731600.0 False True 3900122.7089725807 3535005.1156733483 1552430.6426800832 1.0 0.9063830498309075 0.398046615074079 21.89508808530963 -6.937983293825705 0.6780680817194 1.0059539622253055 0.2687330706219071 0.9978876047682406 0.012155430425106944 0.0886989142329525 0.05889099921284041 0.011658837183943335 0.04415437545141937 1.1534976290083929e-07 6.937983293825705 -0.7372208916033984 down FLCFGSEGGTYYIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLCFGSEGGTYYIK 14 0 P10155-3;P10155-5;P10155-4;P10155;P10155-2 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 0 22349700.0 6117500.0 8488900.0 7743300.0 False True 9280694.74915664 6973989.470921573 6212833.3609910505 1.0 0.7514512285360228 0.6694362360701095 23.145801378302636 -13.999999999999998 0.1549677099517222 2.211959877413521 0.5841610234577539 0.9995505132359304 0.0029796973783752477 11.979901527517015 0.12421278806770328 4.366896297253726 0.0772595862678571 1.0000000000000041e-14 13.999999999999998 -1.6277988539557673 FLCFGSEGGTYYIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLCFGSEGGTYYIK 14 0 P10155-3;P10155-5;P10155-4;P10155;P10155-2 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 0 12232600.0 2974900.0 4225000.0 5032700.0 False True 4074800.9236496347 4038325.529793369 3844079.9117100276 1.0 0.9910485457965401 0.9433785806318705 21.958298146832522 -6.938410485605489 0.6742027796387771 1.0005526434916254 0.9311036963607817 0.9979479775966753 0.0011257564208028783 0.0884995202862219 0.05797139299029462 0.0010830599854615283 0.004132422771781076 1.1523635541992347e-07 6.938410485605489 -0.06944894713084371 FLCFGSEGGTYYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLCFGSEGGTYYIK 14 0 P10155-3;P10155-5;P10155-4;P10155;P10155-2 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 0 14278600.0 6117500.0 8161100.0 0.0 False True 7919224.343953047 7706927.61081654 0.0 1.0 0.973192231471683 0.0 22.916927700395085 -7.045053145048575 1.0576171227028734 1.0140877540686677 4.170766409532018e-19 0.9875540420210963 0.05190001892138394 0.08560496177226809 0.18467490614835771 0.04117894512204517 0.07390186931824896 9.014608181974138e-08 7.045053145048575 -1.0140877540686677 down FLCIFLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLCIFLEK 8 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 11924100.0 3851800.0 3947600.0 4124700.0 False True 5843462.2042994015 3243119.937260421 3309451.237079767 1.0 0.5549997285640444 0.5663510982658185 22.478391976950096 -9.965372579779194 5.1044785008971925 1.0000019465320824 0.560675413415215 0.9994995392084945 0.004634177296295937 1.2125051732508595e-07 2.4573351611821765e-08 0.0044870463289734125 0.0014956742879303386 1.0829974155215035e-10 9.965372579779194 -0.4393265331168674 FLCIFLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLCIFLEK 8 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 2948450.0 524250.0 1106300.0 1317900.0 False True 718079.3923235479 1057420.0079551241 1006639.1630024927 1.0 1.4725669880784968 1.4018493968267611 19.453783834612445 -10.632516545214482 6.388388741436303 0.9980363633651075 1.437208192452629 0.9807557721526028 0.02887033573424334 0.0008103812612611731 4.6616069390278336e-05 0.028055676625363197 0.009317860791511772 2.3306843220601752e-11 10.632516545214482 0.4391718290875215 FLCIFLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLCIFLEK 8 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 9684200.0 3851800.0 2070900.0 3761500.0 False True 4986231.030329118 1955652.5945325952 3076945.596249271 1.0 0.39221058603927383 0.6170884536904774 22.249518299042546 -10.181878897703891 5.374761287807489 1.0000198475524786 0.5046495198647805 0.8661221677115447 0.09180600503214184 2.1835265233574426e-05 3.323559061421969e-06 0.08889433984409867 0.029630260714221836 6.578412497237336e-11 10.181878897703891 -0.4953703276876982 FLCSGGHNALFETFNWALSMGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLCSGGHNALFETFNWALSMGGK 23 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 360562000.0 89142000.0 112370000.0 159050000.0 False True 135234931.15313795 92316695.54918282 127613697.78590848 1.0 0.6826394243114955 0.9436444910923251 27.01089260666822 -9.987715871600216 6.4353320824825 1.0000000571645995 0.8131419587227849 0.405958274976675 0.10655487231569241 8.743020308956555e-08 1.3736503859347216e-08 0.10317134300004357 0.034390437161326066 1.028689077093967e-10 9.987715871600216 -0.18685809844181456 FLDFIGHILT ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLDFIGHILT 10 0 P48426;P48426-2;H7BXS3 P48426 PIP4K2A Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 0 60198000.0 20540000.0 26707000.0 12951000.0 False True 31160681.675141398 21940927.18725657 10391229.17337505 1.0 0.7041221824347977 0.33347245999642905 24.893223458541442 -7.055071379871052 0.31403705747054844 1.0576185503564517 6.422258210267981e-16 0.9999548279556654 0.0018326696696392313 0.07311842237710993 0.012307789175841691 0.00618143905507268 0.03166870796470294 8.80904077276836e-08 7.055071379871052 -1.057618550356451 down FLDFIGHILT ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLDFIGHILT 10 0 P48426;P48426-2;H7BXS3 P48426 PIP4K2A Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 0 48421000.0 20540000.0 15000000.0 12881000.0 False True 26589434.903930634 14165236.81394029 10536790.170221156 1.0 0.5327392953299014 0.39627732624974044 24.66434978063389 -13.999999999999998 0.1725626525971768 3.3726344893216718 0.27912843288211303 0.9995090231823605 0.005728007108375541 12.117475239808478 0.13159290806394983 9.62663778994092 0.10871248405779767 1.0000000000000041e-14 13.999999999999998 -3.093506056439559 FLDGIYVSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLDGIYVSEK 10 0 P32969;D6RAN4;A0A2R8Y5Y7;H0Y9V9;H0Y9R4 P32969 RPL9 60S ribosomal protein L9 0 31869700.0 10132000.0 9721700.0 12016000.0 False True 13283150.118427558 8271260.2548897965 10772699.585610913 1.0 0.6226881561336248 0.8110048813395607 23.66309398870546 -10.152382915631897 5.108405266340125 1.0000132449458252 0.7168465187362569 0.7508984416435825 0.07687998113224513 1.1597669488984891e-05 1.924447360140954e-06 0.07444220176639017 0.02481290721499273 7.0407201785903e-11 10.152382915631897 -0.2831667262095683 FLDGIYVSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLDGIYVSEK 10 0 P32969;D6RAN4;A0A2R8Y5Y7;H0Y9V9;H0Y9R4 P32969 RPL9 60S ribosomal protein L9 0 16315000.0 7619300.0 2393900.0 6301800.0 False True 7377429.492093958 3349796.7540235813 4651169.5300523685 1.0 0.45406015165762004 0.6304593673225622 22.814686796856417 -10.577272799161042 7.650234350148301 1.0002670895773578 0.5422597594900922 0.8997803496691439 0.07201467823437895 0.0003282451454092917 1.8137695552890857e-05 0.0697670501939577 0.023242637457019596 2.646837023430323e-11 10.577272799161042 -0.4580073300872656 FLDGIYVSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLDGIYVSEK 10 0 P32969;D6RAN4;A0A2R8Y5Y7;H0Y9V9;H0Y9R4 P32969 RPL9 60S ribosomal protein L9 0 27584600.0 10132000.0 8977700.0 8474900.0 False True 13878074.207004622 8581035.528716197 6473303.166044323 1.0 0.6183160142194029 0.4664410255694612 23.72630405022835 -13.999999999999922 0.1271646958326431 2.8137717012862424 0.24588852114577073 0.9996586341582102 0.004147107829956418 11.942021007883154 0.11060448869355038 5.428510376813289 0.19596137730887161 1.00000000000018e-14 13.999999999999922 -2.5678831801404716 FLDGIYVSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLDGIYVSEK 10 0 P32969;D6RAN4;A0A2R8Y5Y7;H0Y9V9;H0Y9R4 P32969 RPL9 60S ribosomal protein L9 0 17218000.0 7619300.0 6804200.0 2794500.0 False True 6335785.54222167 6767544.424072045 3378817.029691869 1.0 1.0681460694925884 0.5332909403538733 22.595092072290694 -6.87491109689915 1.1077497407831196 1.0399634819017785 0.49889353680777104 0.9693453991819158 0.04161840130639981 0.13223515513876896 0.30031778956137617 0.029060888191615276 0.06945526735617197 1.3337944412172527e-07 6.87491109689915 -0.5410699450940074 FLDGNELTLADCNLLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLDGNELTLADCNLLPK 17 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 12276700.0 635700.0 7081900.0 4559100.0 False True 833408.8561275573 6025308.125029987 4087368.0659752586 1.0 7.2297145401437675 4.904397206633075 19.668664905198924 -9.549006501376589 8.251314421988623 1.0000000014394987 6.067055873201972 0.8635965828910107 0.9493068261920707 0.0 4.141151323868642e-18 0.9191623820705738 0.3063874606901912 2.8248376868557985e-10 9.549006501376589 5.067055871762474 FLDGNELTLADCNLLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLDGNELTLADCNLLPK 17 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 10647600.0 635700.0 3901700.0 6110200.0 False True 870735.4691465506 3729309.9928034944 4667096.603519103 1.0 4.282942552528346 5.359947732568592 19.731874966721815 -9.26872719092936 0.3749563167798711 3.419713013907003e-23 5.579447401141098 0.9980969035390674 0.08089412697423924 0.657471762790244 0.14556280371543975 1.2369334820904632 0.29025956227401245 5.386080115668271e-10 9.26872719092936 5.579447401141098 FLDGNELTLADCNLLPK(ub)LHIVQVVCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLDGNELTLADCNLLPKLHIVQVVCK 26 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 119318000.0 35467000.0 42129000.0 41722000.0 True False 53806031.98501649 34610750.79462064 33475628.412597805 1.0 0.6432503850917457 0.622153821376753 25.68126458099084 -13.999999999999998 0.4024783119283744 7.110245289008996 0.6209872276562739 0.9998412424607733 0.0021843109620837188 27.139681097659007 0.20938121231722404 144.95148669741747 0.00536153336553169 1.0000000000000041e-14 13.999999999999998 -6.489258061352722 FLDGNELTLADCNLLPK(ub)LHIVQVVCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLDGNELTLADCNLLPKLHIVQVVCK 26 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 82928000.0 35467000.0 23356000.0 24105000.0 True False 45912730.65908991 22056218.06842597 19718137.338186525 1.0 0.4803943863020752 0.4294699325247535 25.45239090308329 -13.999999999999998 0.3284040666865099 6.6021871437471225 0.4202818617561191 0.9997115194735274 0.004378437042468905 18.689422882312126 0.1831675091687648 72.25745262659909 0.016416779724959876 1.0000000000000041e-14 13.999999999999998 -6.181905281991003 FLDGNEMTLADCNLLPK(ub)LHIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLDGNEMTLADCNLLPKLHIVK 22 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 1 11474800.0 4579300.0 4547900.0 2347600.0 True False 4433932.628082087 6363900.186985195 1732693.133509625 1.0 1.435272188548774 0.39078021225124193 22.080155418494144 -6.793489330805332 1.4821366647508196 1.2421711185793245 0.3785401907769613 0.8125188558098215 0.18548405287091604 0.23017477261282923 0.9987388354224697 0.09848189000125959 0.2300208146083312 1.6088319011399915e-07 6.793489330805332 -0.8636309278023632 down FLDGNEMTLADCNLLPK(ub)LHIVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLDGNEMTLADCNLLPKLHIVK 22 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 1 52242000.0 11643000.0 25320000.0 15279000.0 True False 17663282.217316028 20801448.173937045 12259098.952976389 1.0 1.1776660712324771 0.6940442213485272 24.07425011584249 -6.807263506395667 1.4259185768788816 1.0971460817027114 0.686096546719821 0.85257319045173 0.07669253097216687 0.21056307537448588 0.8442835883981044 0.04229642991980007 0.09797113285222935 1.5586065377514937e-07 6.807263506395667 -0.41104953498289043 FLDGNEMTLADCNLLPK(ub)LHIVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLDGNEMTLADCNLLPKLHIVK 22 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 1 10045000.0 4579300.0 3459300.0 2006400.0 True False 3807890.847386989 3440664.064282709 2425928.9634545604 1.0 0.9035616308812332 0.6370794386397016 21.86056069392842 -6.953282761074872 0.5215606838888968 1.0044742318701039 0.5242428957095899 0.9994343590333116 0.0036504096570498692 0.08219371726940598 0.0307095818022172 0.004125248742129191 0.02201503467058415 1.1135692732342039e-07 6.953282761074872 -0.48023133616051394 FLDK(ub)ALELNMLSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLDKALELNMLSLK 14 1 Q9Y617 Q9Y617 PSAT1 Phosphoserine aminotransferase 1 15355700.0 6442700.0 6182200.0 2730800.0 True False 6238180.015055682 8650784.699747099 2015521.5577560428 1.0 1.3867481667519468 0.323094484752225 22.572693754463444 -6.808301142233921 1.421505679818495 1.2111978177858624 0.30517103417240576 0.8554016028353881 0.1671579569046562 0.2091143294133056 0.8331047683088034 0.09246927199973827 0.2140853418977075 1.5548870902701455e-07 6.808301142233921 -0.9060267836134567 down FLDK(ub)ALELNMLSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLDKALELNMLSLK 14 1 Q9Y617 Q9Y617 PSAT1 Phosphoserine aminotransferase 1 13791000.0 3835200.0 5503300.0 4452500.0 True False 5818278.79067683 4521193.11752084 3572461.4233999196 1.0 0.7770671155815992 0.6140065734086869 22.472160996097653 -6.974538236108192 0.10263536334886898 1.3857934009391586 0.001137865836232308 0.9999997143902759 8.435493657918739e-05 0.07485568912917717 0.0030180484301386575 0.01421463021247763 0.02622946533303722 1.0603805763495463e-07 6.974538236108192 -1.3846555351029264 FLDK(ub)ALELNMLSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLDKALELNMLSLK 14 1 Q9Y617 Q9Y617 PSAT1 Phosphoserine aminotransferase 1 6612230.0 773130.0 3455400.0 2383700.0 True False 1058977.0540526554 3302729.0025202325 1820719.15384251 1.0 3.1187918471706673 1.7193187962616407 20.01423989863262 -10.430793817675918 6.13882154747027 0.9995452805479319 2.419055321716149 0.5782206645476372 0.5713324805838575 0.003556648253770205 0.0003297797867971964 0.5533445020737418 0.18439676520405424 3.708567451052479e-11 10.430793817675918 1.419510041168217 FLDK(ub)ALELNMLSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLDKALELNMLSLK 14 1 Q9Y617 Q9Y617 PSAT1 Phosphoserine aminotransferase 1 16322400.0 6442700.0 8717300.0 1162400.0 True False 5357390.510003749 8670338.174651427 1405452.4656696473 1.0 1.6183883102158554 0.2623389993776399 22.35309902989772 -6.782679027753312 1.5251578967104709 1.348912950886193 0.25061643324684824 0.7768937885066326 0.26182730544848776 0.24640410474740954 1.1322072779599546 0.1351836458249247 0.3183067095611473 1.6493809424032732e-07 6.782679027753312 -1.0982965176393447 FLDKYMPQFMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLDKYMPQFMK 11 1 H0YG54;H0YGR4;F5GYG5;Q9Y3B8-2;Q9Y3B8-3;Q9Y3B8 H0YG54 REXO2 Oligoribonuclease, mitochondrial 0 5642600.0 1124100.0 1127400.0 3391100.0 False True 1473705.9857998854 959196.3145707801 3040221.5017281286 1.0 0.6508735960993983 2.0629769648916665 20.491017295155867 -6.841283526950608 1.2763960024653513 0.814292639210123 2.1106223530438215 0.9266436779527856 0.16265275397398307 0.16730375991601434 0.5289085011282549 0.09990031516287179 0.23023937235915046 1.4411741810818514e-07 6.841283526950608 1.2963297138336984 up FLDQNLQK(ub)YQAECSQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLDQNLQKYQAECSQFK 17 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 4033900.0 1026300.0 0.0 3007600.0 True False 1405750.8447146511 0.0 2297266.823466344 1.0 0.0 1.6341920277719333 20.422909483117543 -6.741064871427271 1.682506937452993 0.40577140411139745 1.6354452971551867 0.6099197461715352 0.4201470998784098 0.3158493835690002 1.7559528609845814 0.19750630537123284 0.48415183544756646 1.8152444958542051e-07 6.741064871427271 1.2296738930437892 FLEFQYLTGGLVDPEVHGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLEFQYLTGGLVDPEVHGR 19 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 4967930.0 2502800.0 1679800.0 785330.0 False True 3281195.037149681 1429180.3878091164 704071.5850172966 1.0 0.43556703323878654 0.21457779164170376 21.645789920804937 -11.32245663193879 0.17499223187768495 2.1380271263232102 1.0154054680252759e-14 0.9994984158707546 0.007406554190072186 3.77893150257506 0.10462232470895949 1.8324889458305704 0.16597962836060884 4.759303143752512e-12 11.32245663193879 -2.1380271263232 FLEFQYLTGGLVDPEVHGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLEFQYLTGGLVDPEVHGR 19 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 17180500.0 9633700.0 3751200.0 3795600.0 False True 9327883.466720777 5249073.72224958 2801418.494440762 1.0 0.5627293416536319 0.300327346973772 23.153118334381215 -8.729501373879115 0.1958115835345273 1.358642238894782 3.5191241259568744e-24 0.9996753657013264 0.0051998536628533815 0.27859289664044945 0.05637732750702473 0.19625149615396256 0.1347915843548082 1.864226280812603e-09 8.729501373879115 -1.358642238894782 down FLEFQYLTGGLVDPEVHGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLEFQYLTGGLVDPEVHGR 19 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 8356700.0 2502800.0 2024000.0 3829900.0 False True 3428152.79562685 1934572.9875270466 2925356.4992664414 1.0 0.5643193588088897 0.8533331720214442 21.70899998232783 -10.214891883741275 7.232384165951804 1.0000006108698463 0.7088262654151672 0.575071468650235 0.11798939516446759 1.162164433957245e-06 1.2616353670618648e-07 0.1142429806449698 0.03808091354175575 6.09688658441881e-11 10.214891883741275 -0.291174345454679 FLEFQYLTGGLVDPEVHGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLEFQYLTGGLVDPEVHGR 19 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 15447000.0 9633700.0 2730000.0 3083300.0 False True 8010848.395272656 2715292.9481374263 3728003.774431545 1.0 0.3389519828810852 0.46536940789336445 22.93352360981549 -10.174012377329387 6.043824149810482 1.0000060878020554 0.4021606953905856 0.9675525347785654 0.05160969764612431 4.233620802300983e-06 5.785783413372334e-07 0.04997138308677507 0.016656958290517367 6.698655180749211e-11 10.174012377329387 -0.5978453924114697 FLEIGKFDLSQNHPLGMAIFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLEIGKFDLSQNHPLGMAIFLK 22 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 34362800.0 6631400.0 7753400.0 19978000.0 False True 10060318.620279098 6369745.192409307 16029339.543331526 1.0 0.6331554131466062 1.5933232483333448 23.262172661662866 -6.803167188982017 1.4430887573952509 0.798402113027936 1.6076153482527333 0.8412221674609496 0.1576364638174856 0.2162696764185371 0.8888285135521962 0.08592484346757388 0.19944381129114255 1.5733770498455617e-07 6.803167188982017 0.8092132352247974 FLEIGKFDLSQNHPLGMAIFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLEIGKFDLSQNHPLGMAIFLK 22 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 31118600.0 6631400.0 7635200.0 16852000.0 False True 8584478.024436496 7210294.408119789 13785108.916121949 1.0 0.8399222862001663 1.6058179515261597 23.033298983755316 -6.852146902779482 1.2246255507341626 0.9143894568423985 1.6377367748244336 0.9433748562328501 0.07849232349696272 0.15511593152537118 0.446567507141175 0.05012371959297326 0.11616400909561907 1.405572000336426e-07 6.852146902779482 0.7233473179820351 FLEMCNDLLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLEMCNDLLAR 11 0 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 0 5916500.0 1148100.0 1951400.0 2817000.0 False True 1505170.218216217 1660258.726497625 2525523.8625720707 1.0 1.1030371890198598 1.6778991718060159 20.52149521849525 -6.937393243361276 0.6833864298427892 0.9931644580936219 1.82171292398103 0.9978021238203524 0.013982869889033387 0.08897622893545065 0.0601781272275883 0.013356103949100246 0.05007189576768628 1.1550658837526882e-07 6.937393243361276 0.828548465887408 FLEMCNDLLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLEMCNDLLAR 11 0 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 0 4967900.0 1148100.0 2148100.0 1671700.0 False True 1572583.59623589 2053189.8391832274 1276878.889742215 1.0 1.3056157040539584 0.811962488225447 20.58470528001814 -6.739223106229145 1.6895251870712877 1.1819941783055827 0.8117175534929266 0.601566373537033 0.1284080409135971 0.3191681892038631 1.7885782341193608 0.06013327986562379 0.14768858114752284 1.8229589692847585e-07 6.739223106229145 -0.3702766248126561 FLESTDSFNNELK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLESTDSFNNELKR 14 1 Q969G3;Q969G3-2;A0A2R8Y855;A0A2U3TZQ7;Q969G3-4;Q969G3-3;Q969G3-5;Q969G3-6;B4DGM3;A0A2R8YES3;A0A2R8Y4T4;A0A2R8Y7I9;A0A2R8Y765;A0A2R8Y7U4;J3QKS7;J3QR61 Q969G3 SMARCE1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 1 25923700.0 9070900.0 7885500.0 8967300.0 True False 8782949.244659623 11034221.27233927 6618495.116766424 1.0 1.2563230146238757 0.7535618084996595 23.06627403598579 -6.76811044481234 1.5816424650280279 1.1473752982138783 0.7509311692197388 0.7232878333493445 0.10797624975174129 0.26950096469639545 1.3302235880071291 0.05381961226861402 0.12833868800023743 1.7056485727799166e-07 6.76811044481234 -0.3964441289941395 FLESTDSFNNELK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLESTDSFNNELKR 14 1 Q969G3;Q969G3-2;A0A2R8Y855;A0A2U3TZQ7;Q969G3-4;Q969G3-3;Q969G3-5;Q969G3-6;B4DGM3;A0A2R8YES3;A0A2R8Y4T4;A0A2R8Y7I9;A0A2R8Y765;A0A2R8Y7U4;J3QKS7;J3QR61 Q969G3 SMARCE1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 1 23565600.0 9070900.0 8105800.0 6388900.0 True False 7542855.259005228 8062132.4465246685 7724789.451064014 1.0 1.0688435837210966 1.0241200693651888 22.846679311420065 -10.168264363044091 4.8607479627125105 0.9999957886141604 1.0464818265433014 0.5902033234310974 0.018258298279883425 8.333500366702135e-07 1.426141088992179e-07 0.01768012306194944 0.005892840430594931 6.787903146755135e-11 10.168264363044091 0.046486037929140966 FLETVELQISLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLETVELQISLK 12 0 P62906 P62906 RPL10A 60S ribosomal protein L10a 0 30040600.0 8854000.0 12101000.0 9085600.0 False True 13432165.314104281 9941482.00445547 7289827.177640061 1.0 0.74012504849211 0.5427142241903073 23.67918855543375 -7.1375368236264505 0.13171411852154874 1.3099012684997133 2.673909017339084e-11 0.9999987202384795 0.00021176863749546802 0.08168679036110482 0.004932981167635327 0.01595588174677275 0.03173830496937137 7.285563979372719e-08 7.1375368236264505 -1.3099012684729743 FLFENQTPAHVYYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLFENQTPAHVYYR 14 0 E7ET15;O15042-2;O15042;O15042-3 E7ET15 U2SURP U2 snRNP-associated SURP motif-containing protein 0 11423200.0 3182800.0 3134700.0 5105700.0 False True 4172681.6222790433 2667014.9789648973 4577411.141332699 1.0 0.6391609090722388 1.0969950635324532 21.99254341576254 -6.696577411543127 1.8427104314430933 0.7751785023528578 1.0955607195334884 0.4013315051901205 0.15241391300665555 0.4027869806341775 2.656446408936549 0.06604056701462169 0.1705831750469793 2.011048703526598e-07 6.696577411543127 0.32038221718063065 FLFENQTPAHVYYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLFENQTPAHVYYR 14 0 E7ET15;O15042-2;O15042;O15042-3 E7ET15 U2SURP U2 snRNP-associated SURP motif-containing protein 0 9898000.0 3182800.0 2806400.0 3908800.0 False True 4359567.1719358815 2682403.968476239 2985621.944262952 1.0 0.6152913495045674 0.6848436614264108 22.055753477285432 -10.7414242360271 6.921399600276975 1.0056790811719551 0.6500675054655335 0.9712236873760305 0.028394612439901934 0.0025081847301127126 9.370284239627062e-05 0.027712218195312867 0.009164321758479504 1.8137430611812483e-11 10.7414242360271 -0.35561157570642166 FLFSLFGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLFSLFGQK 9 0 A8MU58;Q13155-2;Q13155 A8MU58 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 0 143662000.0 31813000.0 47564000.0 64285000.0 False True 41707151.077530265 40467636.603019826 57633404.865262866 1.0 0.9702805288185166 1.3818590667611645 25.313791432523725 -6.889544681431767 1.0251003917548036 0.9776433062115446 1.4169408010344446 0.9806042468574915 0.026100083294137943 0.11951224045599493 0.22402565141117664 0.019411879235383765 0.0483142231757026 1.2896008733263077e-07 6.889544681431767 0.43929749482290004 FLFSLFGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLFSLFGQK 9 0 A8MU58;Q13155-2;Q13155 A8MU58 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 0 120322000.0 53015000.0 32810000.0 34497000.0 False True 51332067.843943805 45911204.10188968 25461200.812183283 1.0 0.8943961548844231 0.49600964624274757 25.613357042977704 -6.946221469255265 0.5988933581092948 1.00449837784789 0.36555263072623007 0.9988703989143035 0.007293863517883791 0.08503946081431898 0.04252207975137991 0.007494185758850388 0.033467360505880714 1.1318230408413252e-07 6.946221469255265 -0.63894574712166 down FLFSLFGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLFSLFGQK 9 0 A8MU58;Q13155-2;Q13155 A8MU58 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 0 159711000.0 48556000.0 48080000.0 63075000.0 False True 73663001.91909279 39499748.3492454 50608198.6032454 1.0 0.5362223547803503 0.6870232991431783 26.13443685544242 -10.37343304937941 5.0657381759627755 1.0002601534410405 0.611622826961721 0.8984130232145046 0.06156422773661108 0.00018100447997055691 2.2387983318776957e-05 0.05964868033143694 0.019869769062146388 4.232207481872496e-11 10.37343304937941 -0.3886373264793195 FLFSLFGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLFSLFGQK 9 0 A8MU58;Q13155-2;Q13155 A8MU58 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 0 218640000.0 31813000.0 70777000.0 116050000.0 False True 43575125.813999094 67649838.11175981 88641380.12477368 1.0 1.5524874994170732 2.034219717531979 25.377001494046617 -6.9727311607542415 0.18145270342317632 0.6346889095923067 2.9650641510167315 0.9999965940396525 0.0007798006643641242 0.07542605019540888 0.005731805514196311 0.01831458275447271 0.05382430360691227 1.0648019535389965e-07 6.9727311607542415 2.3303752414244245 FLFSLFGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLFSLFGQK 9 0 A8MU58;Q13155-2;Q13155 A8MU58 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 0 120087000.0 53015000.0 38239000.0 28833000.0 False True 44084321.46271727 38032998.917152755 34861846.99127063 1.0 0.8627330001964031 0.7907992191907453 25.39376231841198 -13.99999999822162 0.08140034236018488 1.7340584397908647 0.5814452863086105 0.9998808274079869 0.0009473598822271297 12.244785022777588 0.08068075368342377 1.6083152569538206 0.18980487093996726 1.0000000040948716e-14 13.99999999822162 -1.1526131534822541 FLFSLFGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLFSLFGQK 9 0 A8MU58;Q13155-2;Q13155 A8MU58 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 0 164082000.0 48556000.0 63793000.0 51733000.0 False True 62856699.18185279 60242863.471446216 42318124.8254057 1.0 0.9584159565419686 0.6732476470483081 25.90556317753487 -6.933077930229127 0.7210785225607875 1.0038803207914127 0.6098343926946457 0.9971093574843632 0.007808070265395388 0.09107089451261913 0.0700794254301488 0.007248532614260493 0.025380274207978476 1.1666002623792404e-07 6.933077930229127 -0.394045928096767 FLGCVDIK(ub)DLPVSEQQER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLGCVDIKDLPVSEQQER 18 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 91156000.0 26695000.0 26000000.0 38461000.0 True False 34557203.73711917 24553077.144163128 31461492.643185716 1.0 0.7105053212910789 0.9104177780852033 25.042483147980207 -10.083715619770485 5.186758937342531 1.0000033508202455 0.8104615503697621 0.545153343025533 0.08161391872983695 3.162492107280836e-06 5.585015569481016e-07 0.07902373462690364 0.02634077900477535 8.246779453498562e-11 10.083715619770485 -0.1895418004504834 FLGSGGFIGYAPNLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLGSGGFIGYAPNLSK 16 0 Q02809;Q02809-2;Q5JXB8;Q5JXB7 Q02809 PLOD1 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 0 14879000.0 3995000.0 5161400.0 5722600.0 False True 5237483.687635031 4391339.238979621 5130480.247055342 1.0 0.8384444708337634 0.9795696851844506 22.320442414808298 -10.222747269298218 6.045802571460911 1.0000018192444209 0.9090070780155983 0.3566234798258371 0.05761412750001566 1.4128117359158789e-06 1.8156684462350158e-07 0.05578575419337741 0.0185948796928191 5.98759932426283e-11 10.222747269298218 -0.09099474122882256 FLGSGGFIGYAPNLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLGSGGFIGYAPNLSK 16 0 Q02809;Q02809-2;Q5JXB8;Q5JXB7 Q02809 PLOD1 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 0 9364300.0 4992400.0 0.0 4371900.0 False True 4833918.994701596 0.0 3226768.23581135 1.0 0.0 0.6675263361566824 22.204761866399227 -10.378466028415266 7.841230836536752 1.000008913274763 0.3337631680783413 0.5704812249666713 0.27251648557557157 4.246415959645395e-05 3.365718982151806e-06 0.26386647650621214 0.08795431751676357 4.183444113025566e-11 10.378466028415266 -0.6662457451964217 FLGSGGFIGYAPNLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLGSGGFIGYAPNLSK 16 0 Q02809;Q02809-2;Q5JXB8;Q5JXB7 Q02809 PLOD1 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 0 14091900.0 3995000.0 4040600.0 6056300.0 False True 5472059.460815584 3862072.931522622 4625926.673413755 1.0 0.7057805126530914 0.8453721503830813 22.38365247633119 -10.068624898424467 4.687050673111138 1.000009675341559 0.7755763315126991 0.775095568487552 0.056988047484780556 5.761987255878319e-06 1.1449180075452044e-06 0.05518081785296756 0.018392813234173418 8.538372576889231e-11 10.068624898424467 -0.22443334382885993 FLHCTEK(ub)DLIPYLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLHCTEKDLIPYLEK 15 1 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 1 7754500.0 2727300.0 3331400.0 1695800.0 True False 3575516.711210771 2834368.1056954917 1520334.8832622324 1.0 0.7927156645104015 0.42520704168304785 21.769720315504543 -6.962331439987137 0.4012327046180594 1.0199297866394907 0.18454716610504915 0.999847120665289 0.0029387459552707184 0.07887865347127798 0.018130078585289276 0.004728144057380921 0.030777143208263535 1.090607701026816e-07 6.962331439987137 -0.8353826205344416 down FLHCTEK(ub)DLIPYLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLHCTEKDLIPYLEK 15 1 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 1 20837100.0 6612100.0 5406300.0 8818700.0 True False 8559493.793976609 5105434.65248036 7213787.087503242 1.0 0.596464554489554 0.8427819753289205 23.029094047899886 -10.335277352353062 5.880737533987514 1.0000345686604273 0.7196232649092368 0.6333715701539445 0.1005586659691414 4.558144126978823e-05 5.152159914750338e-06 0.09737749214986349 0.032455169884609635 4.620858264824959e-11 10.335277352353062 -0.2804113037511905 FLHFPYLLTLQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLHFPYLLTLQLK 13 0 Q96K76-2;Q96K76-4;Q96K76 Q96K76-2 USP47 Ubiquitin carboxyl-terminal hydrolase 47 0 141876000.0 35976000.0 53717000.0 52183000.0 False True 54578222.19790104 44130781.65716334 41869007.17737864 1.0 0.8085785846439775 0.7671376144419162 25.7018220660049 -13.999999999999998 0.21504933029709583 2.130683414788767 0.7438911256810913 0.999493437027202 0.002282774396493312 12.869712029052431 0.1469473245710888 6.163743466792686 0.023707280305601805 1.0000000000000041e-14 13.999999999999998 -1.3867922891076758 FLHFPYLLTLQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLHFPYLLTLQLK 13 0 Q96K76-2;Q96K76-4;Q96K76 Q96K76-2 USP47 Ubiquitin carboxyl-terminal hydrolase 47 0 95269000.0 35976000.0 29456000.0 29837000.0 False True 46571641.19297999 27816747.70609498 24406972.15347317 1.0 0.5972894017376386 0.5240736965299855 25.47294838809735 -13.999999999999998 0.23976955171823805 3.662585670950827 0.4916306834047493 0.9995245801665965 0.004562348113993504 13.615354726910597 0.15498109193012646 17.35528735474684 0.03582465672848049 1.0000000000000041e-14 13.999999999999998 -3.1709549875460774 FLHK(ub)HDLDLICR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLHKHDLDLICR 12 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62136 PPP1CC;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 33636600.0 1549800.0 7130800.0 24956000.0 True False 2351159.905556675 5858253.0268053105 20023435.661396604 1.0 2.491643810767637 8.516407418344322 21.164941231287678 -6.944651641584452 0.6147661181942847 0.9337562014289482 10.390623068240936 0.9987118854963849 0.11661692062353445 0.08570712841675676 0.04541705070479083 0.1180095858570901 0.5088903463597044 1.1359216013363686e-07 6.944651641584452 9.456866866811987 FLHK(ub)HDLDLICR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLHKHDLDLICR 12 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62136 PPP1CC;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 24838800.0 1549800.0 5507000.0 17782000.0 True False 2006246.6511252031 5200530.6089579435 14545858.45872777 1.0 2.592169116415086 7.250284231288175 20.936067553380127 -6.952013557332368 0.5362829761991383 0.9296930755310536 9.126506831641795 0.9993499722422471 0.06761505952376044 0.0826871400205611 0.032693099045206335 0.07475445590866464 0.38553733390011635 1.1168283833036805e-07 6.952013557332368 8.19681375611074 FLHLLNRPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLHLLNRPR 9 1 A3KMH1-2;A3KMH1-3;A3KMH1 A3KMH1-2 VWA8 von Willebrand factor A domain-containing protein 8 0 9647300.0 2669700.0 2332600.0 4645000.0 False True 3500002.553411579 1984585.1724035863 4164379.957986251 1.0 0.5670239213023257 1.1898219771088678 21.73892454389403 -6.719746105172698 1.7602683518489601 0.7365101273791131 1.188834361233548 0.5112947992017722 0.1822036864322946 0.35581441663026897 2.154532189056406 0.0821926892539622 0.20639295926899004 1.906575003504436e-07 6.719746105172698 0.45232423385443477 FLHLLNRPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLHLLNRPR 9 1 A3KMH1-2;A3KMH1-3;A3KMH1 A3KMH1-2 VWA8 von Willebrand factor A domain-containing protein 8 0 4762740.0 1705300.0 861140.0 2196300.0 False True 1651166.1849340287 1204997.692785774 1621023.1424123321 1.0 0.7297858348727744 0.9817443920565143 20.65505389982036 -10.491530289770232 8.187944221187466 1.0000099025875506 0.8557651135607829 0.3040763969319594 0.10286165023800331 1.8595558070196006e-05 1.1547378798379646e-06 0.09960219871325673 0.03319845486126658 3.224554415656485e-11 10.491530289770232 -0.14424478902676774 FLHLLNRPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLHLLNRPR 9 1 A3KMH1-2;A3KMH1-3;A3KMH1 A3KMH1-2 VWA8 von Willebrand factor A domain-containing protein 8 0 9220400.0 2669700.0 3186400.0 3364300.0 False True 3656760.2359297583 3045614.3119842787 2569721.6299334457 1.0 0.8328723010219206 0.702731780083491 21.80213460541692 -6.973925248976724 0.13466986113456278 1.1882541764913555 0.34396961615439875 0.9999990895773151 0.00011595096633035356 0.07504831439399812 0.004059109625587508 0.0077831448062282635 0.017375263802424854 1.0618783125939596e-07 6.973925248976724 -0.8442845603369566 FLHLLNRPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLHLLNRPR 9 1 A3KMH1-2;A3KMH1-3;A3KMH1 A3KMH1-2 VWA8 von Willebrand factor A domain-containing protein 8 0 3571400.0 1705300.0 1866100.0 0.0 False True 1418032.507599206 1856046.9489081495 0.0 1.0 1.3088888575978572 0.0 20.435459175254636 -6.8805023940596115 1.338917082774393 1.161284288686033 2.0258829422098912e-18 0.9307733832867779 0.14698073923048965 0.14847504405496628 0.5350399874702938 0.08907397939456255 0.18141179089112208 1.316732654178657e-07 6.8805023940596115 -1.161284288686033 down FLHVFFSSPLPGEEPIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLHVFFSSPLPGEEPIGR 18 0 Q14669-4;Q14669;Q14669-2;Q14669-3 Q14669-4 TRIP12 E3 ubiquitin-protein ligase TRIP12 0 15666500.0 6507200.0 5281200.0 3878100.0 False True 8423698.67608848 4987296.577452093 3172325.5926663033 1.0 0.5920554342249965 0.37659533117812843 23.006022400003104 -10.3647843944072 0.13241187743893718 1.8233828607513929 1.6483724374711714e-19 0.9997950935768256 0.0037005379957541756 2.11637608531745 0.06762798475728062 0.7992439643027115 0.22808908238257966 4.317333577555998e-11 10.3647843944072 -1.8233828607513929 FLIATGERPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLIATGERPR 10 1 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9;E9PKD3 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 10893800.0 3338600.0 3460700.0 4094500.0 False True 4376936.931048396 2944377.049702948 3670840.4172173673 1.0 0.6727026448145985 0.8386779327748048 22.061490165108477 -10.127122579598375 5.187390203807081 1.0000072441082282 0.7556902887944374 0.7428582398059081 0.06775912756992349 5.67691941143203e-06 9.553723836891088e-07 0.06560943817864465 0.02186916438585548 7.462381030110439e-11 10.127122579598375 -0.24431695531379072 FLIATGERPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLIATGERPR 10 1 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9;E9PKD3 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 11824700.0 3338600.0 4410100.0 4076000.0 False True 4572970.642272576 4215247.199749517 3113332.7478550375 1.0 0.9217743846382349 0.6808118816848212 22.12470022663137 -6.950854753961602 0.5493777377557072 1.0033447941923221 0.5879334423888007 0.9992666760360898 0.0036784333321459284 0.0831442885470294 0.03455560278539686 0.003995683188408684 0.019987551059581065 1.1198123324106207e-07 6.950854753961602 -0.4154113518035214 FLIATGERPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLIATGERPR 10 1 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9;E9PKD3 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 4085340.0 2065400.0 1406100.0 613840.0 False True 1717471.6127340612 1398525.0602110033 742191.1059245147 1.0 0.8142929698760357 0.4321417020354781 20.711854822949064 -6.95948353893158 0.4426517581425478 1.0132924014205864 0.2181769382383462 0.9997505636469666 0.003733684897335614 0.07988611320715093 0.021816839444341384 0.005055520240638903 0.031648183853427096 1.0977828987621879e-07 6.95948353893158 -0.7951154631822402 down FLICTDVAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLICTDVAAR 10 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 9240800.0 3169700.0 3213400.0 2857700.0 False True 4155507.3954184647 2733973.245735092 2562012.6169940336 1.0 0.6579156251170087 0.6165342455697966 21.986593212905074 -13.999999999999998 0.2979588918297431 4.084062161984345 0.6061354426784671 0.9996452725972723 0.003236582436444122 16.456633490550114 0.1732975827690254 31.253294999561646 0.015087439422705936 1.0000000000000041e-14 13.999999999999998 -3.477926719305878 FLIDNPSEK(ub)ITEIELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLIDNPSEKITEIELR 16 1 Q9P2I0 Q9P2I0 CPSF2 Cleavage and polyadenylation specificity factor subunit 2 1 6122900.0 1993300.0 2456900.0 1672700.0 True False 1930023.782577254 3437952.982564238 1234569.6900756306 1.0 1.7813008386732794 0.6396655322179761 20.88018719443145 -6.7225060203188525 1.7502718764608791 1.4740727242822829 0.6411965003681974 0.524235422944525 0.32867984513745085 0.3505202778462939 2.0998665532472445 0.1490274800798668 0.37302021465393687 1.8944972520920425e-07 6.7225060203188525 -0.8328762239140854 FLIDNPSEK(ub)ITEIELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLIDNPSEKITEIELR 16 1 Q9P2I0 Q9P2I0 CPSF2 Cleavage and polyadenylation specificity factor subunit 2 1 6000300.0 1993300.0 4007000.0 0.0 True False 1657517.2681624878 3985413.4956727703 0.0 1.0 2.4044476472278156 0.0 20.660592469865726 -6.750213523955931 1.661225026227627 1.827339983657013 1.8665563918721685e-10 0.6418898351876354 0.5901826164946655 0.3013696825294507 1.6385136763947226 0.2812513768387145 0.6794111231746129 1.7774053212740238e-07 6.750213523955931 -1.8273399834703574 FLIDNPSEK(ub)ITEIELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLIDNPSEKITEIELR 16 1 Q9P2I0 Q9P2I0 CPSF2 Cleavage and polyadenylation specificity factor subunit 2 1 14842900.0 2870600.0 5343700.0 6628600.0 True False 3716048.2879855507 5046318.397510182 5422262.815179559 1.0 1.3579797694840408 1.4591475661687212 21.825337818188082 -12.37308883397492 0.2017797506982241 4.4471967879413973e-10 1.5289988152718008 0.9994177635735362 0.004752978007127448 6.256978047515734 0.13013199011907792 2.615989655238235 0.06332882094153564 4.235563196805741e-13 12.37308883397492 1.5289988148270812 FLIIPLHSLMPTVNQTQVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLIIPLHSLMPTVNQTQVFK 20 0 Q9H2U1-3;Q9H2U1;E7EWK3 Q9H2U1-3 DHX36 ATP-dependent RNA helicase DHX36 0 259131000.0 113000000.0 88546000.0 57585000.0 False True 109412876.85307278 123902879.56128985 42501760.98703 1.0 1.1324341624585492 0.38845300671605887 26.705207298681266 -6.8608974909341605 1.1812692390447943 1.072024808052488 0.3518163342120725 0.954718032318992 0.06895498662450172 0.14587522819282794 0.38629386515853587 0.045513679977494635 0.10634661010832416 1.377534578064494e-07 6.8608974909341605 -0.7202084738404154 down FLIIPLHSLMPTVNQTQVFK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FLIIPLHSLMPTVNQTQVFK 20 0 Q9H2U1-3;Q9H2U1;E7EWK3 Q9H2U1-3 DHX36 ATP-dependent RNA helicase DHX36 0 357131100.0 116390000.0 120977500.0 119763600.0 False True 96783441.95125276 120325770.19534627 144805615.035679 1.0 1.2432474787986063 1.496181703360103 26.528256911524036 -6.970634198241481 0.24256108583906683 0.9120147001014327 1.8347535213097308 0.9999869144086375 0.0007327838745271398 0.07609744621163476 0.008290407654508327 0.00593804311973652 0.024547520198708702 1.0699557124386741e-07 6.970634198241481 0.9227388212082981 FLILPDMLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 FLILPDMLK 9 0 P62318;P62318-2 P62318 SNRPD3 Small nuclear ribonucleoprotein Sm D3 0 43516220.0 11881320.0 19030200.0 12604700.0 False True 15576525.57886654 16190968.339138592 11300486.556820082 1.0 1.0394467146836452 0.7254818476433553 23.89287013322521 -6.875392368941288 1.1051264332791684 1.0232341975881898 0.7051034105949948 0.969777149111434 0.02427576241085093 0.13179212739102691 0.29758932740220917 0.016985088760630436 0.040635992335348814 1.3323171891324784e-07 6.875392368941288 -0.31813078699319497 FLILPDMLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 FLILPDMLK 9 0 P62318;P62318-2 P62318 SNRPD3 Small nuclear ribonucleoprotein Sm D3 0 28631280.0 15268500.0 7021500.0 6341280.0 False True 14783809.825054357 9825221.566638773 4680308.533677757 1.0 0.6645933411553911 0.3165833833810527 23.81751476775728 -7.301787982187806 0.2886605108972688 1.0851353974729783 3.764935422429555e-11 0.999885452520405 0.0029862521917666035 0.10494303122696826 0.01984238867903833 0.013920768834339908 0.048664207693870365 4.991280968647888e-08 7.301787982187806 -1.0851353974353288 down FLILPDMLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLILPDMLK 9 0 P62318;P62318-2 P62318 SNRPD3 Small nuclear ribonucleoprotein Sm D3 0 17496100.0 2417700.0 11135000.0 3943400.0 False True 3667827.657545735 9147872.251847913 3163985.2615463776 1.0 2.4940845388490955 0.8626319328382798 21.80649442105827 -6.665826902409764 1.9519178264691646 1.9570857734590663 0.8693101142440587 0.26067032062263196 0.6352756217123718 0.47085613384459735 3.4543497931968608 0.26237696153035966 0.7049060988478199 2.158604596920197e-07 6.665826902409764 -1.0877756592150076 FLILPDMLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FLILPDMLK 9 0 P62318;P62318-2 P62318 SNRPD3 Small nuclear ribonucleoprotein Sm D3 0 57246820.0 11881320.0 19076400.0 26289100.0 False True 16274165.084600102 18233541.570781086 20080156.021009825 1.0 1.1203979728603772 1.2338670473492523 23.9560801947481 -6.971842129157254 0.2095741564297305 0.940268640484036 1.417162467300428 0.9999934040390923 0.0002451746646428881 0.07570937651090685 0.006848648253294308 0.003409391131167317 0.011769751804388126 1.0669839111839747e-07 6.971842129157254 0.4768938268163919 FLILPDMLK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FLILPDMLK 9 0 P62318;P62318-2 P62318 SNRPD3 Small nuclear ribonucleoprotein Sm D3 0 27269670.0 15268500.0 6133140.0 5868030.0 False True 12696434.25923794 6100099.557487023 7095007.942294789 1.0 0.4804576964629722 0.5588189406118063 23.597920043191557 -10.699628514251017 6.794161372900096 1.0043731664506064 0.5196383185374764 0.9804320773884756 0.031990843962382894 0.002128459204448399 9.409954786610957e-05 0.031111234199823787 0.010325000491452416 1.996969747700914e-11 10.699628514251017 -0.48473484791312993 FLILPDMLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLILPDMLK 9 0 P62318;P62318-2 P62318 SNRPD3 Small nuclear ribonucleoprotein Sm D3 0 12242400.0 2417700.0 5790000.0 4034700.0 False True 3129760.309991876 5467781.410180943 3300425.9995179903 1.0 1.7470288036834156 1.0545299552113487 21.57762074315072 -10.178539739705064 4.74151279912671 0.9999489566032574 1.4007793794496117 0.3087202893184646 0.28271147104457645 0.00015256601446213275 2.643234362506283e-05 0.27376898066424554 0.09124473492703394 6.629186851491209e-11 10.178539739705064 0.4008304228463543 FLILPDMLK(ub)NAPMLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLILPDMLKNAPMLK 15 1 P62318;P62318-2 P62318 SNRPD3 Small nuclear ribonucleoprotein Sm D3 1 17092100.0 5298400.0 3789600.0 8004100.0 True False 8038060.164925466 3113316.271720059 6422086.126678341 1.0 0.387321842315288 0.7989596985976144 22.938415945341728 -10.114538598942886 5.8817863416472855 1.0000025197032596 0.5931407704565022 0.5657000654906372 0.16805045111752978 5.552640258857813e-06 8.360062229013217e-07 0.16271515565679515 0.05423804987506085 7.681771790928025e-11 10.114538598942886 -0.40686174924675744 FLILPDMLK(ub)NAPMLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLILPDMLKNAPMLK 15 1 P62318;P62318-2 P62318 SNRPD3 Small nuclear ribonucleoprotein Sm D3 1 11572700.0 5298400.0 0.0 6274300.0 True False 6858883.247078189 0.0 5132441.779754565 1.0 0.0 0.7482911714441167 22.709542267434177 -10.749295101969542 9.45565180043205 1.0026662145770802 0.3741455869101785 0.4825903639217277 0.3054885915112621 0.017185740046106717 0.0004556580799664756 0.2960501108132697 0.09859601894828993 1.7811680571008045e-11 10.749295101969542 -0.6285206276669016 FLINLEGGDIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLINLEGGDIR 11 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 4846090.0 2095500.0 696990.0 2053600.0 False True 2028979.4995187086 975301.7417548331 1515700.5533205671 1.0 0.4806858531523769 0.7470260560444817 20.95232285773461 -10.39876264873888 4.985402422235832 1.000388453639504 0.6138559545983793 0.7370233092283669 0.10873293251267371 0.0004699267282552563 5.667297141562127e-05 0.10538399967364674 0.035093403067131886 3.992430376429845e-11 10.39876264873888 -0.38653249904112474 FLINLEGGDIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLINLEGGDIR 11 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 6596600.0 1717000.0 2186500.0 2693100.0 False True 2351821.300180314 2089893.2002114088 2057045.2461355275 1.0 0.888627550082643 0.8746605220293795 21.165347012517984 -13.999999998681155 0.29277256487095743 1.9748478161483722 0.8709596734604679 0.999633658872087 0.0010734373162947098 16.132418523524372 0.17164829664696193 9.4873290536583 0.005209716592194627 1.000000003036754e-14 13.999999998681155 -1.1038881426879044 FLIPNASQAESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLIPNASQAESK 12 0 P63104;E7EX29;E7ESK7;B0AZS6;P63104-2 P63104 YWHAZ 14-3-3 protein zeta/delta 0 15481000.0 5056300.0 3035600.0 7389100.0 False True 4895790.524178684 4247730.910444878 5453673.04175156 1.0 0.8676292193194839 1.113951468065817 22.22311040019097 -6.760739280115657 1.6097113111312324 0.9231824905314463 1.1148837511577712 0.6939755046015964 0.055681441403461394 0.2816742007386076 1.438664348282828 0.027290496745829628 0.06553495657706045 1.7348451643114897e-07 6.760739280115657 0.19170126062632487 FLIPNASQAESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLIPNASQAESK 12 0 P63104;E7EX29;E7ESK7;B0AZS6;P63104-2 P63104 YWHAZ 14-3-3 protein zeta/delta 0 7125220.0 5056300.0 1155000.0 913920.0 False True 4204537.482069928 1148777.7857504499 1105016.446511359 1.0 0.2732233427932 0.2628152207522598 22.003515675625245 FLIQNVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLIQNVLR 8 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 9176400.0 2655500.0 2724800.0 3796100.0 False True 3481386.2158985813 2318270.461187213 3403315.9867624515 1.0 0.6659044177863053 0.9775749588541474 21.731230441085785 -10.497277395643895 8.623786907816699 1.0000082353496784 0.8217396887066748 0.3037039694592566 0.12723896557889375 2.0147495333885324e-05 1.174548512854124e-06 0.12320428658038374 0.04106619955630953 3.182164337952347e-11 10.497277395643895 -0.17826854664300362 FLIQNVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLIQNVLR 8 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 5746700.0 2263500.0 1061900.0 2421300.0 False True 2191646.43147726 1485922.2077353457 1787088.8925570182 1.0 0.67799357888844 0.8154093045712884 21.06358364285183 -10.131305850268562 4.710606487201464 1.0000200187324533 0.7467014417281448 0.8191794612798756 0.05609973510297293 78342606.67516814 0.6443450058024 17411.915546812488 0.019204431489703206 7.39084594167993e-11 10.131305850268562 -0.2533185770043085 FLIQNVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLIQNVLR 8 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 8918600.0 2655500.0 2557100.0 3706000.0 False True 3637310.1121891853 2444118.866801094 2830719.1274658446 1.0 0.6719577906240317 0.778245197729957 21.794440502608676 -10.708416833163225 9.85775211276208 1.0003671282468116 0.7251014941769944 0.8991841574384736 0.04339165224883066 0.00035055276237490443 1.0369016320517463e-05 0.042066976281618894 0.014004595543678739 1.9569654884379028e-11 10.708416833163225 -0.2752656340698172 FLK(ub)FGMTPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLKFGMTPSK 10 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 32759100.0 8607000.0 14742000.0 9410100.0 True False 11283860.350306572 12542551.063865937 8436433.120053038 1.0 1.1115478811757156 0.747654867939218 23.42775738048278 -6.824424743326796 1.3526519893700923 1.0598690587284925 0.7389329034609834 0.8942563042941297 0.04949937938795385 0.1877910948938481 0.6739076755658455 0.028747702083443065 0.06619275765072755 1.4982188492464595e-07 6.824424743326796 -0.32093615526750907 FLK(ub)FGMTPSK ddPTM_RPMI8226_Bortezomib_2h_R1 2 FLKFGMTPSK 10 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 59897200.0 23626000.0 16871700.0 19399500.0 True False 22876005.562218536 23608657.7947532 14318188.977474855 1.0 1.0320271050180498 0.6259042444508947 24.44733182565153 -6.887833837803621 1.0351513470156202 1.0229682168491505 0.5924261324494822 0.9794737304778942 0.02641374499115265 0.12091665521222403 0.23227506065221556 0.01949617402284948 0.048238514867739946 1.2946910988765244e-07 6.887833837803621 -0.43054208439966835 FLK(ub)FGMTPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLKFGMTPSK 10 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 91878000.0 28673000.0 63205000.0 0.0 True False 43499037.27708509 51925573.927081056 0.0 1.0 1.1937177734835753 0.0 25.374480135725896 -6.918164948327601 1.2626288514771908 1.1019182186117498 2.0512202934422555e-16 0.9581734462035686 0.10697736818453829 0.12333962508250769 0.39360938204998336 0.0696422758643039 0.1362453151263517 1.2073551853856626e-07 6.918164948327601 -1.1019182186117495 down FLK(ub)FGMTPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLKFGMTPSK 10 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 47192000.0 8607000.0 14890000.0 23695000.0 True False 11789240.495429235 14232110.565354621 18098729.013843283 1.0 1.2072118276722323 1.5351904154351825 23.490967442005672 -6.9643489415454365 0.36905960398332965 0.9745077747296754 1.7792939854088283 0.9998990830931774 0.0022134406796949866 0.0781826313099156 0.015643484066995395 0.004329281747278654 0.027869141804957778 1.0855530664104211e-07 6.9643489415454365 0.8047862106791529 FLK(ub)FGMTPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FLKFGMTPSK 10 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 61110300.0 23626000.0 23450500.0 14033800.0 True False 19646065.809264503 23324167.501940195 16968202.695040178 1.0 1.1872182312929649 0.8636946887879443 24.227737101085808 -6.74978216798691 1.6505980411156032 1.1101101555705115 0.8630585391856651 0.6481341831074195 0.07866907047787695 0.30038479304236615 1.6101084002474249 0.037651153281439025 0.09142962251260175 1.7791715773655855e-07 6.74978216798691 -0.2470516163848464 FLK(ub)NEVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLKNEVER 8 1 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 1 1609440.0 694040.0 771730.0 143670.0 True False 950645.3437257707 737632.4168301615 109738.10497652939 1.0 0.77592808053867 0.11543537839931307 19.858547691149806 -7.1725387783962455 0.6488720491685204 0.9996253549959997 6.667541026271964e-21 0.9974948214713969 0.01879377650020328 0.08447435375973583 0.061051123158359796 0.017847129876950578 0.053371943831408704 6.721422904724741e-08 7.1725387783962455 -0.9996253549959997 down FLK(ub)NIGWGTDQGIGGFGEEPGIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLKNIGWGTDQGIGGFGEEPGIK 23 1 A0A1W2PNR9;Q9Y5U9 A0A1W2PNR9 IER3IP1 Immediate early response 3-interacting protein 1 1 87383700.0 7332700.0 53669000.0 26382000.0 True False 9492324.699126191 50682272.97115741 21580746.7021795 1.0 5.339289855500089 2.273494363732216 23.178330020236057 -6.555773014000169 2.364261434663508 3.996626501040278 2.2778176563107166 0.0 1.8966046162462193 0.7749717775460495 8.114002644678257 0.684545043909479 2.136326592442243 2.781166477358704e-07 6.555773014000169 -1.7188088447295615 FLK(ub)PLLIGELAPEEPSQDHGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLKPLLIGELAPEEPSQDHGK 21 1 O95864;O95864-4;O95864-2;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 59016400.0 3872200.0 5675500.0 49468700.0 True False 5076491.698438136 4828737.522925728 44350153.46127757 1.0 0.9511957883061971 8.736378604720777 22.275400381714995 -6.9054888485839205 0.9259203307874839 0.7232365146035172 9.651098404304411 0.9891046423447535 0.3818794964000242 0.10747688770906193 0.15551273614742778 0.3058374562680511 0.8200446661913213 1.2431145549922104e-07 6.9054888485839205 8.927861889700894 up FLK(ub)PLLIGELAPEEPSQDHGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLKPLLIGELAPEEPSQDHGK 21 1 O95864;O95864-4;O95864-2;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 143033900.0 6327900.0 10980000.0 125726000.0 True False 6127024.278217332 15364371.259943567 92794588.90084812 1.0 2.5076400161439962 15.145131582185742 22.54675513730244 -6.929238270361733 0.7530230147031811 0.8022855359710165 17.68988369056498 0.9963862773650376 0.381284172095202 0.09303557324208706 0.07963348732845799 0.34580538024878416 1.148305145208867 1.1769600715895175e-07 6.929238270361733 16.887598154593963 FLK(ub)PLLIGELAPEEPSQDHGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLKPLLIGELAPEEPSQDHGK 21 1 O95864;O95864-4;O95864-2;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 79009400.0 3872200.0 5925200.0 69212000.0 True False 5303856.982270362 5663405.071983824 52865551.06588403 1.0 1.0677899292751205 9.967378691130257 22.338610443237886 -6.908568834038454 0.9054155028001335 0.7118206403636714 11.083014156961639 0.990370359646763 0.4132653608930484 0.10537251781075048 0.14395349531959897 0.3359690926819289 0.9184949700800272 1.234329663066835e-07 6.908568834038454 10.371193516597968 up FLK(ub)PLLIGELAPEEPSQDHGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLKPLLIGELAPEEPSQDHGK 21 1 O95864;O95864-4;O95864-2;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 97854900.0 6327900.0 10087000.0 81440000.0 True False 5261929.223501434 10032659.328887254 98468727.46398507 1.0 1.9066503753182837 18.71342682151495 22.327160412736717 -6.918047189208204 0.839086640114732 0.602431854547675 21.305531892655175 0.9936209836803043 0.6505233033804998 0.09933439096639657 0.11166997041768943 0.5547724943469049 1.6320034399859766 1.207682604606454e-07 6.918047189208204 20.7031000381075 up FLK(ub)SGDAAIVDMVPGKPMCVESFSDYPPLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLKSGDAAIVDMVPGKPMCVESFSDYPPLGR 31 2 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 39691000.0 16165000.0 13495000.0 10031000.0 True False 15651850.923273653 18883623.8754953 7403580.176450426 1.0 1.2064786438398882 0.4730162721804109 23.89982993861744 -6.831539298434371 1.3210894274080738 1.1102137947424249 0.4526614215375117 0.9089068252535148 0.09320610067450291 0.17891851662220812 0.6101698512505234 0.0553871143315101 0.12745377245682857 1.4738751669393988e-07 6.831539298434371 -0.6575523732049131 down FLK(ub)SGDAAIVDMVPGKPMCVESFSDYPPLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLKSGDAAIVDMVPGKPMCVESFSDYPPLGR 31 2 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 537816000.0 47425000.0 61819000.0 428572000.0 True False 71947192.2319172 50786916.45594838 343864556.3502198 1.0 0.7058915696423563 4.779402026444537 26.100435050522083 -6.889542703774182 1.0250603316251334 0.7787206093005792 5.126669785391636 0.9806048331166373 0.25831706730561604 0.1195159154708918 0.22400945301551775 0.19212259401987167 0.4781939025293784 1.2896067458272542e-07 6.889542703774182 4.347949176091056 up FLLADNLYCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLLADNLYCK 10 0 P61758;P61758-2 P61758 VBP1 Prefoldin subunit 3 0 4919100.0 1344800.0 1647000.0 1927300.0 False True 1763045.823061724 1401274.0199557187 1727881.4839670386 1.0 0.7948029493199736 0.9800547787047199 20.749638541341763 -10.345059378174692 7.015114292693939 1.0000028638068885 0.8874288640370729 0.3299127883690325 0.07562874265162588 3.3874753114829385e-06 3.1624040006474185e-07 0.07322907771081269 0.024409071732029462 4.517941693622678e-11 10.345059378174692 -0.11257399976981564 FLLDTNK(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLLDTNKSR 9 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 35848500.0 10614000.0 18056000.0 7178500.0 True False 13915056.786122203 15362115.181736747 6435737.681034296 1.0 1.1039922738265595 0.4625017188181942 23.730143460404573 -6.8653453521058925 1.1585016849480336 1.057440614032244 0.42812225340160365 0.9598090617298101 0.05635695523607888 0.1413922689141583 0.35761848882256164 0.03785206918966712 0.08895616231890618 1.3634984478467887e-07 6.8653453521058925 -0.6293183606306405 down FLLDTNK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLLDTNKSR 9 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 37812000.0 13192000.0 11053000.0 13567000.0 True False 12773227.180935722 15466520.540633542 10013395.698724257 1.0 1.2108545727361375 0.7839362407700252 23.60661973504146 -6.77240461020639 1.5651415879924964 1.120570173621239 0.7813082218671014 0.7396889032233902 0.08892549583116208 0.262571026092148 1.2697045641647715 0.044773963668191696 0.10635194344326969 1.688866766712136e-07 6.77240461020639 -0.33926195175413765 FLLDTNK(ub)SR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLLDTNKSR 9 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 76042000.0 28125000.0 21204000.0 26713000.0 True False 42667681.21291871 17419980.532391824 21433163.841276173 1.0 0.4082710856834068 0.5023278329638111 25.346640373215006 -10.806029630409327 7.271705467732786 1.0211671510621452 0.45529945932360916 0.9781263858754089 0.03839850628381666 0.012161375343350848 0.00032440030784276736 0.03431371727695176 0.012393064613038565 1.563040998125673e-11 10.806029630409327 -0.565867691738536 FLLDTNK(ub)SR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLLDTNKSR 9 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 25954800.0 10614000.0 9060900.0 6279900.0 True False 14538282.632564858 8660559.47761058 4796716.958600311 1.0 0.5957071888402734 0.3299369726005986 23.793353521927465 -8.340890852650938 0.1960377848521538 1.3005572332217215 2.946080725499296e-23 0.999769991561687 0.004178141287204045 0.10279023957842433 0.044785693682005 0.12560420254131882 0.1213868667057903 4.561515420352768e-09 8.340890852650938 -1.3005572332217215 down FLLDTNK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLLDTNKSR 9 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 41029900.0 13192000.0 20874000.0 6963900.0 True False 10969732.5046905 20761547.618835382 8420019.292564401 1.0 1.892621138205334 0.7675683330440485 23.387025010475735 -6.695322444596345 1.8478044982129118 1.5568232503286437 0.7712263872246032 0.3952462499836852 0.3771215512927231 0.40536246678254817 2.687466673399016 0.16303578206334612 0.4216833349064311 2.0168683713862956e-07 6.695322444596345 -0.7855968631040404 FLLDTNK(ub)SR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLLDTNKSR 9 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 59104000.0 28125000.0 16808000.0 14171000.0 True False 36408366.92663329 15872620.024580568 11592023.406738915 1.0 0.4359607794704326 0.318388996411129 25.117766695307456 -13.999999999999998 0.22040584948034203 4.409723555974424 0.2557436376535961 0.9994983021410382 0.006663587662375136 13.010656592499586 0.1487227760354856 19.312732936258136 0.06489320958247823 1.0000000000000041e-14 13.999999999999998 -4.153979918320828 FLLELQISNNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLLELQISNNR 11 0 P13489;H0YCR7 P13489 RNH1 Ribonuclease inhibitor 0 198475000.0 53891000.0 74009000.0 70575000.0 False True 81756586.95983651 60801515.715043694 56625820.3158787 1.0 0.7436895053472922 0.6926147778612202 26.28483163447318 -13.999999999999998 0.22677715067791346 2.594251775639612 0.6670078594212744 0.9995055644028563 0.0029905139027620767 13.193007235405192 0.15080768043818255 9.453630540823331 0.02705439557247812 1.0000000000000041e-14 13.999999999999998 -1.9272439162183375 FLLELQISNNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLLELQISNNR 11 0 P13489;H0YCR7 P13489 RNH1 Ribonuclease inhibitor 0 134299000.0 53891000.0 34430000.0 45978000.0 False True 69762961.8504247 32513940.23359759 37610475.77411907 1.0 0.46606307087862914 0.5391181047438585 26.055957956565628 -10.586949575024201 6.441470608232225 1.0010865802995477 0.5025905878114224 0.9840792454404862 0.029824592685259492 0.0004662917570497903 2.9900305988551075e-05 0.028933082250250104 0.009625845898119127 2.5885134443009117e-11 10.586949575024201 -0.49849599248812526 FLLFSSLVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLLFSSLVTK 10 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 9796700.0 1817000.0 5810200.0 2169500.0 False True 2382104.5958530274 4943340.80798221 1945020.9513134903 1.0 2.0751988878187815 0.8165136638834206 21.183805331227074 -6.680471873043099 1.8999499575717607 1.6799859338868863 0.8212544408051593 0.32642207782379806 0.4556449395561052 0.43746290723555176 3.0534833816917573 0.1923934339422696 0.5071666941644049 2.0870272852578258e-07 6.680471873043099 -0.858731493081727 FLLFSSLVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLLFSSLVTK 10 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 12073100.0 5605900.0 2689900.0 3777300.0 False True 5427943.773014518 3763991.0976431887 2787911.8134289905 1.0 0.6934469580094379 0.5136220878501597 22.37197434556855 -10.362792568191779 0.09600434572965724 1.868285017121202 1.6670881747311478e-13 0.9999286303743309 0.0016963349049487191 2.1653527301870046 0.04987043751820763 0.7322875019765052 0.29313987366373395 4.3371798537993726e-11 10.362792568191779 -1.8682850171210352 FLLFSSLVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLLFSSLVTK 10 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 38415000.0 10524000.0 12111000.0 15780000.0 False True 15965677.407458015 9949697.4263251 12661076.083380293 1.0 0.6231929389777923 0.7930184081926865 23.928470430501772 -10.02191532111718 4.630615247216642 1.000008186592696 0.7081056735691529 0.7975292742283355 0.06933095753637526 22057486.654039707 23869210.645962376 1565.9976588385944 0.023733830468597096 9.507901609666603e-11 10.02191532111718 -0.2919025130235431 FLLFSSLVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLLFSSLVTK 10 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 17954600.0 1817000.0 5381600.0 10756000.0 False True 2488794.0025787014 5143823.1174286315 8215654.326773518 1.0 2.0667934397539485 3.3010583914382123 21.247015392749965 -6.969212895123654 0.276340081717537 0.7158206940375422 4.689454888023876 0.9999755756542718 0.004646716932009857 0.07655894136805147 0.00994084850379561 0.02328990992898179 0.1138229828294882 1.0734630619385248e-07 6.969212895123654 3.973634193986334 FLLFSSLVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLLFSSLVTK 10 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 10523100.0 5605900.0 2558200.0 2359000.0 False True 4661554.233478202 2544418.4688370572 2852255.993216366 1.0 0.5458304980265238 0.6118680273485021 22.152379621002826 -10.54275926980852 6.3060556368494955 1.0005508737541589 0.5788492626875679 0.9818935957201386 0.02695970845215485 0.00020905793425434247 1.5158446644062358e-05 0.026136090855864463 0.008701208487816933 2.8657660288598357e-11 10.54275926980852 -0.421701611066591 FLLFSSLVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLLFSSLVTK 10 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 40350000.0 10524000.0 16684000.0 13142000.0 False True 13623525.459053827 15755520.7335853 10750290.8483073 1.0 1.156493653639015 0.7890975710081671 23.69959675259422 -6.790949683944287 1.4923990060065646 1.0873548273874787 0.7850791997229289 0.8044442831986521 0.06656958283858966 0.2339286716729334 1.0292459352784145 0.03510716221041077 0.08214284139975635 1.618267514401737e-07 6.790949683944287 -0.30227562766454974 FLLGYFPWDSTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLLGYFPWDSTK 12 0 Q8TC07-2;Q8TC07-3;Q8TC07;C9JA93 Q8TC07-2 TBC1D15 TBC1 domain family member 15 0 3376120.0 972230.0 893190.0 1510700.0 False True 1274602.9450887116 759929.5336273502 1354387.2556576573 1.0 0.596208832370507 1.0625954230502683 20.28161646867186 -6.677742423062344 1.9101785010907708 0.7439991124713604 1.060780063188272 0.3137486402316122 0.1712215128489287 0.44353043022616584 3.1269959938436274 0.07198187672714489 0.190379426326181 2.100185119025288e-07 6.677742423062344 0.3167809507169116 FLLGYFPWDSTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLLGYFPWDSTK 12 0 Q8TC07-2;Q8TC07-3;Q8TC07;C9JA93 Q8TC07-2 TBC1D15 TBC1 domain family member 15 0 6464630.0 972230.0 2603100.0 2889300.0 False True 1331689.7045278428 2488086.434699436 2206906.847001367 1.0 1.8683680036270909 1.6572230298828032 20.34482653019475 -10.181696722058852 4.668564425151052 0.9998950231988898 1.7627955166754885 0.9456574104825655 0.08619957480040265 0.00010352744915880996 1.814621964196689e-05 0.08347486991226295 0.027820793103333366 6.581172555170496e-11 10.181696722058852 0.7629004934765987 FLLGYFPWDSTK(ub)EER ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLLGYFPWDSTKEER 15 1 Q8TC07-2;Q8TC07-3;Q8TC07;C9JA93 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 9123000.0 2810500.0 4551800.0 1760700.0 True False 3684592.716920718 3872689.182777435 1578519.6538269925 1.0 1.051049459277527 0.42841089235669727 21.81307372656788 -6.887022479444598 1.0398647638844263 1.0358820992898663 0.3778865262668002 0.9789219631945685 0.04097821882026234 0.12159102009308086 0.23624078353064878 0.030138047491479796 0.07437076301181038 1.2971121296406647e-07 6.887022479444598 -0.6579955730230661 down FLLGYFPWDSTK(ub)EER ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLLGYFPWDSTKEER 15 1 Q8TC07-2;Q8TC07-3;Q8TC07;C9JA93 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 19758000.0 9615900.0 5943500.0 4198600.0 True False 9310648.51797754 8316770.544943037 3098860.7046999093 1.0 0.893253625554067 0.3328297377692273 23.150450229168936 -6.938722572483625 0.6713413055354777 1.0064510700149814 0.18721566986188629 0.9979917666900366 0.013112826356666885 0.08835424397571755 0.057299719172109416 0.012644050903121347 0.04851232673377883 1.1515357556176735e-07 6.938722572483625 -0.819235400153095 down FLLGYFPWDSTK(ub)EER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLLGYFPWDSTKEER 15 1 Q8TC07-2;Q8TC07-3;Q8TC07;C9JA93 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 10767700.0 2810500.0 5694000.0 2263200.0 True False 3849617.8009066875 5442420.252459983 1728678.7720671091 1.0 1.4137559970701892 0.4490520517802986 21.87628378809077 -6.790172722427913 1.4957505645499436 1.231200326604736 0.4387609894869209 0.8018319292386772 0.17591149794475733 0.2351060409547268 1.0391363868852452 0.09257152216341887 0.21669531209633602 1.621165218611681e-07 6.790172722427913 -0.7924393371178151 down FLLGYFPWDSTK(ub)EER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLLGYFPWDSTKEER 15 1 Q8TC07-2;Q8TC07-3;Q8TC07;C9JA93 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 21614100.0 9615900.0 8596600.0 3401600.0 True False 7996046.906598944 8550288.409508502 4112858.8327786303 1.0 1.0693144386699578 0.5143615189881374 22.930855504603212 -6.875601050234486 1.1040961291589735 1.040897175493282 0.4782134049783171 0.9699579023609093 0.042793761824695915 0.13159519797959562 0.29647342389433745 0.029966902583257956 0.07172056841483174 1.3316771559321152e-07 6.875601050234486 -0.562683770514965 FLLGYFPWDSTK(ub)EER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLLGYFPWDSTKEER 15 1 Q8TC07-2;Q8TC07-3;Q8TC07;C9JA93 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 48896800.0 18103000.0 20812000.0 9981800.0 True False 23434690.363478884 19653793.90478165 8165214.821917043 1.0 0.8386624102962562 0.3484242674117805 24.482142397196828 -6.9511633584913355 0.54592695260321 1.0069493689268374 0.1572671230565364 0.9992894163148116 0.007385812611673914 0.08302202225097005 0.03405550426157759 0.008059006377678743 0.040639099366995474 1.1190168896420125e-07 6.9511633584913355 -0.8496822458703011 down FLLK(ub)SCPLLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLLKSCPLLTK 11 1 P08910;H3BMT2;H3BUZ6 P08910 ABHD2 Abhydrolase domain-containing protein 2 1 74913500.0 21908200.0 31796400.0 21208900.0 True False 28721862.359310593 27052501.06139642 19014406.478134442 1.0 0.9418783755374057 0.66201857805264 24.77564596244742 -6.940649705930068 0.6534942459236339 1.0031096055387776 0.5850854347129143 0.9982477236895815 0.006176344431412355 0.08747158265795538 0.05326987705338004 0.006042207546680632 0.02401887411954738 1.1464372641753157e-07 6.940649705930068 -0.4180241708258633 FLLK(ub)SCPLLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLLKSCPLLTK 11 1 P08910;H3BMT2;H3BUZ6 P08910 ABHD2 Abhydrolase domain-containing protein 2 1 47325700.0 14628600.0 18860400.0 13836700.0 True False 14164223.100290796 26391456.0756867 10212453.177897684 1.0 1.8632476973018643 0.7210034115946691 23.75574813708211 -6.704559497133256 1.8145260722551715 1.5336255854111056 0.724084824709295 0.4392834901369186 0.3640923061324078 0.3861096981625535 2.47453664139546 0.15988709403674978 0.40890171274322595 1.9744243702460056e-07 6.704559497133256 -0.8095407607018106 FLLK(ub)SCPLLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLLKSCPLLTK 11 1 P08910;H3BMT2;H3BUZ6 P08910 ABHD2 Abhydrolase domain-containing protein 2 1 169179900.0 22356900.0 79689000.0 67134000.0 True False 33917051.808323696 65467875.33700119 53864935.47412247 1.0 1.9302348478571036 1.588137311536709 25.01550743534014 -10.381321311108422 5.4956606679976945 0.9996977960758828 1.7591860796969137 0.8678388596278146 0.13966073437472576 0.0005173238193569428 5.823818132472535e-05 0.13527774894597994 0.04507530819603055 4.156030144233414e-11 10.381321311108422 0.7594882836210308 FLLK(ub)SCPLLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLLKSCPLLTK 11 1 P08910;H3BMT2;H3BUZ6 P08910 ABHD2 Abhydrolase domain-containing protein 2 1 76331600.0 21908200.0 17616300.0 36807100.0 True False 30008253.58684356 16837953.616686128 28114021.046019454 1.0 0.5611107480132849 0.9368762818755108 24.838856023970312 -10.125996700150843 7.5018831581447145 1.0000000696649465 0.7489935149443979 0.37301800962571086 0.15340563681449454 1.7879807407123347e-07 2.065261548725064e-08 0.1485344112023685 0.0495114563830734 7.48175185261889e-11 10.125996700150843 -0.25100655472054856 FLLK(ub)SCPLLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLLKSCPLLTK 11 1 P08910;H3BMT2;H3BUZ6 P08910 ABHD2 Abhydrolase domain-containing protein 2 1 47816600.0 14628600.0 9841800.0 23346200.0 True False 12164329.05686138 9788780.26995565 28227782.479367454 1.0 0.8047118936193374 2.3205375608813674 23.536153412516388 -6.874522359381079 1.1098442586149353 0.8858608544996552 2.417308278553888 0.9689943359296562 0.11855299898162253 0.13259521407621422 0.30252122017004 0.08264867346200147 0.19737121792996593 1.3349888567227123e-07 6.874522359381079 1.531447424054233 up FLLK(ub)SCPLLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLLKSCPLLTK 11 1 P08910;H3BMT2;H3BUZ6 P08910 ABHD2 Abhydrolase domain-containing protein 2 1 133541500.0 22356900.0 78708000.0 32476600.0 True False 28941447.770383976 74327830.61010739 26566192.038056344 1.0 2.5682139746363233 0.9179289249393304 24.78663375743259 -6.657719439154198 1.9806639199773162 2.0113508200617054 0.9248031592247479 0.22593498737484952 0.6680808587277327 0.4899774972894168 3.692592422314938 0.2727186702273051 0.7405713297997625 2.1992801824381896e-07 6.657719439154198 -1.0865476608369575 FLLLGLRPFIPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLLLGLRPFIPEK 13 1 C9JUH3;A0A0A0MT72;Q9BSQ5-3;Q9BSQ5-4;Q9BSQ5;Q9BSQ5-2 C9JUH3 CCM2 Cerebral cavernous malformations 2 protein 0 8399110.0 661310.0 2392300.0 5345500.0 False True 905814.1782307785 2286600.275721816 4083002.9940282446 1.0 2.524359113243255 4.507550325612146 19.78885559574485 -6.967514607920698 0.31189703077337266 0.7012371677863626 6.393885378971065 0.9999559915483652 0.009526455350012229 0.07711773892452761 0.011902854743346668 0.03111278806034369 0.17574886918693988 1.077669004631129e-07 6.967514607920698 5.692648211184703 FLLLSAHSHFISLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLLLSAHSHFISLR 14 0 Q68CP9-3;Q68CP9;F8WCU9 Q68CP9-3 ARID2 AT-rich interactive domain-containing protein 2 0 34538400.0 9043400.0 11556000.0 13939000.0 False True 13719498.96109901 9493741.51255989 11183950.54031926 1.0 0.6919889377504926 0.8151865146118544 23.7097244591671 -10.017936937112227 4.828918527164089 1.0000044602563734 0.7535877264154391 0.8421237370531485 0.05029520016106062 69450698.3324802 12.060202737510293 3444.279784803914 0.017217384786296076 9.595399539568291e-11 10.017936937112227 -0.2464167338409342 FLLLSAHSHFISLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLLLSAHSHFISLR 14 0 Q68CP9-3;Q68CP9;F8WCU9 Q68CP9-3 ARID2 AT-rich interactive domain-containing protein 2 0 30334400.0 9043400.0 9749000.0 11542000.0 False True 11706859.57206457 9206459.579940265 9441474.430920923 1.0 0.7864158208499511 0.8064907905319536 23.480850781259548 -10.758757563584174 6.901506477065556 1.004402788420961 0.7964533056909578 0.9927575357498788 0.008195572053791404 0.0005644611566205806 1.9730736642806815e-05 0.008067632938777247 0.0026451095064147553 1.742779474516066e-11 10.758757563584174 -0.20794948273000313 FLLMLQSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLLMLQSVK 9 0 Q9BXJ9;A0A0B4J1W3;Q6N069 Q9BXJ9;Q6N069 NAA15;NAA16 N-alpha-acetyltransferase 15, NatA auxiliary subunit;N-alpha-acetyltransferase 16, NatA auxiliary subunit 0 6996100.0 1329200.0 3536800.0 2130100.0 False True 1742594.0719911093 3009123.2263384177 1909697.6853620051 1.0 1.7268067616574392 1.0958935968260015 20.732805109797628 -10.241467445554724 4.709514026100285 0.9998898735051197 1.4113501792430805 0.36175277650193227 0.25756922097824675 0.0002979059688393584 4.798144345241149e-05 0.24945672646785105 0.0831301086113696 5.7349885405354785e-11 10.241467445554724 0.4114603057379608 FLLMLQSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLLMLQSVK 9 0 Q9BXJ9;A0A0B4J1W3;Q6N069 Q9BXJ9;Q6N069 NAA15;NAA16 N-alpha-acetyltransferase 15, NatA auxiliary subunit;N-alpha-acetyltransferase 16, NatA auxiliary subunit 0 5667700.0 2878100.0 1706100.0 1083500.0 False True 2786736.2908922904 2387354.627193966 799698.8456967436 1.0 0.8566848018581458 0.28696610020486957 21.41014505586261 -6.945018104990686 0.6111085121149692 1.0062920355954117 0.10763376644326182 0.9987499277641924 0.010888226773026519 0.08555032314608553 0.04473405356282698 0.011056046061849466 0.04805882068392458 1.1349635000080037e-07 6.945018104990686 -0.8986582691521499 down FLLMLQSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLLMLQSVK 9 0 Q9BXJ9;A0A0B4J1W3;Q6N069 Q9BXJ9;Q6N069 NAA15;NAA16 N-alpha-acetyltransferase 15, NatA auxiliary subunit;N-alpha-acetyltransferase 16, NatA auxiliary subunit 0 13587700.0 3969600.0 5049100.0 4569000.0 False True 6022173.416632975 4148048.656201646 3665935.1473361594 1.0 0.6887959494399347 0.6087395519383433 22.521852822340954 -13.999999999999998 0.1906293166315042 2.671883559415647 0.5516685528907507 0.999489073021175 0.003814760860537806 12.361022048228767 0.13845885245355766 7.6780447503894225 0.05478153709054128 1.0000000000000041e-14 13.999999999999998 -2.120215006524896 FLLMLQSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLLMLQSVK 9 0 Q9BXJ9;A0A0B4J1W3;Q6N069 Q9BXJ9;Q6N069 NAA15;NAA16 N-alpha-acetyltransferase 15, NatA auxiliary subunit;N-alpha-acetyltransferase 16, NatA auxiliary subunit 0 8672300.0 1329200.0 2324900.0 5018200.0 False True 1820641.1602793678 2222178.2305838116 3833004.513073153 1.0 1.2205470682882014 2.1053047666378135 20.79601517132052 -6.94480881993607 0.613206260631543 0.9902547168845693 2.381925897597486 0.9987282304621258 0.017033024442709155 0.08563988624334995 0.045124529449763084 0.01726155067940858 0.07468994301552681 1.135510566917329e-07 6.94480881993607 1.3916711807129167 up FLLMLQSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLLMLQSVK 9 0 Q9BXJ9;A0A0B4J1W3;Q6N069 Q9BXJ9;Q6N069 NAA15;NAA16 N-alpha-acetyltransferase 15, NatA auxiliary subunit;N-alpha-acetyltransferase 16, NatA auxiliary subunit 0 6502800.0 2878100.0 1674700.0 1950000.0 False True 2393267.671448584 1665678.058698077 2357735.984218699 1.0 0.6959848572599839 0.9851534838105347 21.190550331296887 -10.603324296680901 8.875226875767138 1.0000480823230522 0.8405691706742373 0.28841024762565726 0.11805259744504558 0.00011234996885384563 5.0215180233468345e-06 0.11433829845777961 0.03810131199009913 2.4927326567240923e-11 10.603324296680901 -0.1594789116488149 FLLMLQSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLLMLQSVK 9 0 Q9BXJ9;A0A0B4J1W3;Q6N069 Q9BXJ9;Q6N069 NAA15;NAA16 N-alpha-acetyltransferase 15, NatA auxiliary subunit;N-alpha-acetyltransferase 16, NatA auxiliary subunit 0 13621000.0 3969600.0 5897600.0 3753800.0 False True 5138725.452514268 5569393.375592952 3070646.917240597 1.0 1.0838083153222298 0.597550296394643 22.292979144433403 -6.862483093000859 1.1732088602695323 1.045801923284231 0.5728712041501676 0.9565831130093091 0.044225167066904256 0.14426092573382965 0.37592056169454263 0.029371249325215818 0.06876050227492242 1.3725143916840486e-07 6.862483093000859 -0.4729307191340635 FLLQEEISK(ub)CK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLLQEEISKCK 11 1 Q14790;Q14790-9;Q14790-7;Q14790-3;E7ETB7;E7EQ06;Q14790-2;Q14790-4;A0A0A0MS31;Q14790-8;C9JB29;Q14790-5;Q14790-6 Q14790;Q14790-2;Q14790-5 CASP8 Caspase-8;Caspase-8 subunit p18;Caspase-8 subunit p10 1 19445100.0 2571800.0 2724300.0 14149000.0 True False 3901608.6237647827 2238127.3799469457 11352443.948272988 1.0 0.5736422065284722 2.9096829136384943 21.895637635617476 -6.859627921758703 1.1875951052417364 0.7688948086083878 3.0220123592023116 0.9531856036747575 0.21977439455728554 0.14718957410300076 0.3946757287912984 0.14435612197172892 0.33683466643401494 1.381567404269015e-07 6.859627921758703 2.253117550593924 up FLLQVFTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLLQVFTK 8 0 Q96IR7 Q96IR7 HPDL 4-hydroxyphenylpyruvate dioxygenase-like protein 0 5553700.0 1677700.0 2176200.0 1699800.0 False True 2199480.9468699135 1851519.442761161 1523921.0016329451 1.0 0.8417983549237208 0.6928548318646001 21.06873167319765 -6.9718541521852 0.20921521356609293 1.0787655899850876 0.451733329511754 0.999993457752669 0.0003207206618713797 0.07570555381467342 0.006833785710704427 0.004488089628197259 0.015462307941322985 1.066954373162316e-07 6.9718541521852 -0.6270322604733336 FLLQVFTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLLQVFTK 8 0 Q96IR7 Q96IR7 HPDL 4-hydroxyphenylpyruvate dioxygenase-like protein 0 9808400.0 4428800.0 3065500.0 2314100.0 False True 4288210.168202554 4289570.136371316 1707967.788488083 1.0 1.0003171412116987 0.39829386188970184 22.031944184353353 -6.906775154743256 0.9174137847138006 1.0205937224255255 0.3256287393244767 0.9896466818551971 0.028869046367262747 0.10658941900446188 0.15061992773556898 0.023264899780802695 0.06287360797185307 1.2394381089617517e-07 6.906775154743256 -0.6949649831010487 down FLLQVFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLLQVFTK 8 0 Q96IR7 Q96IR7 HPDL 4-hydroxyphenylpyruvate dioxygenase-like protein 0 38206700.0 11864700.0 12353000.0 13989000.0 False True 17999617.32575706 10148510.635570468 11224068.018403495 1.0 0.5638181330137597 0.6235725913095995 24.10146289920531 -10.351012215015338 5.775885545680616 1.0000725057773499 0.5936953621618232 0.9840371710693049 0.02439465544687515 2.2780582481049863e-05 2.5596602475139005e-06 0.02362421660464577 0.00787334119018398 4.4564371399611874e-11 10.351012215015338 -0.4063771436155267 FLLQVFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLLQVFTK 8 0 Q96IR7 Q96IR7 HPDL 4-hydroxyphenylpyruvate dioxygenase-like protein 0 10132400.0 1677700.0 3157200.0 5297500.0 False True 2297991.0281377523 3017704.4645357686 4046339.6054372163 1.0 1.313192448354012 1.760816102365853 21.13194173472054 -6.966047941074609 0.3395862910699452 0.9512155322268667 2.1376594723525453 0.9999331458972252 0.0025527902612757455 0.077607122241153 0.01361589557261358 0.0063268475778456785 0.038755505624539034 1.0813145801190256e-07 6.966047941074609 1.1864439401256786 FLLQVFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLLQVFTK 8 0 Q96IR7 Q96IR7 HPDL 4-hydroxyphenylpyruvate dioxygenase-like protein 0 8553000.0 4428800.0 2046900.0 2077300.0 False True 3682743.429106523 2035872.943422162 2511653.8256499995 1.0 0.5528142219552039 0.682006192937355 21.81234945978763 -10.52289196969665 9.351038700516101 1.0000132214084831 0.6174102074462835 0.9212178375548067 0.052742401295120166 1.4538306957306131e-05 7.417689174552437e-07 0.05106937141755943 0.017022536821249067 2.9999086503592296e-11 10.52289196969665 -0.38260301396219965 FLLQVFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLLQVFTK 8 0 Q96IR7 Q96IR7 HPDL 4-hydroxyphenylpyruvate dioxygenase-like protein 0 41728700.0 11864700.0 15056000.0 14808000.0 False True 15359088.038201837 14218120.364712337 12113095.942910865 1.0 0.9257138398678598 0.7886598418332267 23.87258922129776 -6.9615919039672765 0.41238670088422436 1.006578181210472 0.7026894740504377 0.99982475221193 0.0011588306246411396 0.07913731336468652 0.019065885951870105 0.0017661587589817146 0.011434300741612169 1.0924664185821059e-07 6.9615919039672765 -0.30388870716003424 FLLSLPEHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLLSLPEHR 9 0 Q15008;Q15008-4;C9J7B7 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 0 6270200.0 1536800.0 1777700.0 2955700.0 False True 2014759.682392368 1512474.089420328 2649872.517076414 1.0 0.7506970199167299 1.3152300694889325 20.942176335771123 -6.7866488012226425 1.5095652205020462 0.8600556769528772 1.3207030646420042 0.7903271027139778 0.10577177808069894 0.2403824924857682 1.0821692323526333 0.05516121671042735 0.12947542282879596 1.6343730740634448e-07 6.7866488012226425 0.46064738768912694 FLLSLPEHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLLSLPEHR 9 0 Q15008;Q15008-4;C9J7B7 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 0 3998780.0 1298700.0 918080.0 1782000.0 False True 1257473.4793724376 1284674.1317239527 1315240.7411459154 1.0 1.0216311936575315 1.0459391491916852 20.262096542650138 -6.969612128537604 0.26727797501643336 0.993754304504752 1.0745441729633447 0.9999791064994433 8.55800426441553e-05 0.07642868059540732 0.009479080935646214 0.00048455916265945445 0.002269359219175425 1.072476714151128e-07 6.969612128537604 0.0807898684585927 FLLSLPEHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLLSLPEHR 9 0 Q15008;Q15008-4;C9J7B7 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 0 7360100.0 1536800.0 2922800.0 2900500.0 False True 2104996.4904584195 2793661.0315929134 2215461.6376726045 1.0 1.3271570970574487 1.0524775921075897 21.005386397294014 -10.250033814702679 4.486344926436379 0.9999180185869827 1.1898173445842712 0.38902715589879533 0.11213743832747779 9.19942828914591e-05 1.5378693410864867e-05 0.10862342498740724 0.03619220259318147 5.62297542307431e-11 10.250033814702679 0.18989932599728854 FLMANGQLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLMANGQLVK 10 0 P31150;G5E9U5;P50395;Q5SX86;V9GYJ7;V9GYF8;Q5SX90 P31150;P50395 GDI1;GDI2 Rab GDP dissociation inhibitor alpha;Rab GDP dissociation inhibitor beta 0 18720300.0 6147600.0 5427400.0 7145300.0 False True 8059563.133443093 4617653.075839505 6405972.8985574 1.0 0.5729408653278725 0.7948288005805013 22.942270209281318 -10.525446361915488 7.632607630911628 1.0000754675107455 0.6838848329542027 0.7301828257138643 0.09058537024144205 0.00011635882372002215 7.234581168469128e-06 0.0877296926226403 0.029236302529594825 2.982315859840254e-11 10.525446361915488 -0.31619063455654284 FLMANGQLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLMANGQLVK 10 0 P31150;G5E9U5;P50395;Q5SX86;V9GYJ7;V9GYF8;Q5SX90 P31150;P50395 GDI1;GDI2 Rab GDP dissociation inhibitor alpha;Rab GDP dissociation inhibitor beta 0 10380400.0 6147600.0 0.0 4232800.0 False True 8420533.852643287 0.0 3233099.817252408 1.0 0.0 0.3839542568001798 23.00548027080421 -10.661759160707641 6.59881173278897 1.004736265451275 0.19197712840009973 0.8551794518418099 0.15674866895499648 0.01092942397525606 0.0005602177044612401 0.15187255266760677 0.05059041536690676 2.1789177626793556e-11 10.661759160707641 -0.8127591370511753 FLMANGQLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLMANGQLVK 10 0 P31150;G5E9U5;P50395;Q5SX86;V9GYJ7;V9GYF8;Q5SX90 P31150;P50395 GDI1;GDI2 Rab GDP dissociation inhibitor alpha;Rab GDP dissociation inhibitor beta 0 20648000.0 8915000.0 6003100.0 5729900.0 False True 11540643.240922177 5669022.207850997 4687116.99373885 1.0 0.49122237725442447 0.4061400128130394 23.46022030194069 -13.999999999999998 0.2516371398698615 4.567712502875119 0.37245856543788897 0.9995457895827945 0.005588166715691163 14.063531168604932 0.15873290676153437 25.386744954882708 0.03891097188986917 1.0000000000000041e-14 13.999999999999998 -4.195253937437229 FLMSLVNQVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLMSLVNQVPK 11 0 O00303;H0YDT6 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 38813000.0 12640000.0 12526000.0 13647000.0 False True 16571162.405934105 10657169.625965571 12234939.351267654 1.0 0.6431153931693565 0.7383271644773902 23.982171470057423 -10.029664456902067 7.002126632759208 1.0000000496521082 0.6907212788233742 0.9336377811403657 0.038870042868541815 3.013861367332863e-08 4.164801393352551e-09 0.037635763343014904 0.012545252391352455 9.339756271199209e-11 10.029664456902067 -0.309278770828734 FLMSLVNQVPK ddPTM_RPMI8226_Bortezomib_2h_R1 2 FLMSLVNQVPK 11 0 O00303;H0YDT6 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 43652200.0 17887600.0 6803700.0 18960900.0 False True 17319767.929177195 9520452.890826773 13994471.475192798 1.0 0.5496870933696776 0.8080057153431864 24.04591626346392 -10.194731789447312 5.531514492082575 1.0000112813224338 0.6788464043564054 0.673296658330313 0.10545813581576083 1.4672458377130245e-05 2.1357863810727555e-06 0.10211298516380876 0.034036466978029686 6.386577851781235e-11 10.194731789447312 -0.32116487696602836 FLMSLVNQVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLMSLVNQVPK 11 0 O00303;H0YDT6 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 43838000.0 12640000.0 14202000.0 16996000.0 False True 17313349.583156183 13574508.680266354 12981894.843607534 1.0 0.7840486680562799 0.7498199456584278 24.045381531580315 -13.999999998955603 0.25926375401185997 2.5748169025427625 0.7372210651091636 0.9995608327010109 0.0023209743060896796 14.384672129448575 0.1611269691675364 11.863232572018674 0.015022569297542596 1.000000002404812e-14 13.999999998955603 -1.8375958374335988 FLMSLVNQVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLMSLVNQVPK 11 0 O00303;H0YDT6 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 33839300.0 15888000.0 9191000.0 8760300.0 False True 13211575.957741247 9141486.258729333 10592038.22694925 1.0 0.6919300383216531 0.801724053271851 23.65529923456664 -10.3692088015258 4.93485872820148 1.0001952323841388 0.7468270457966912 0.8763830673020889 0.04482321890679247 9.635270316926746e-05 1.2316035924362128e-05 0.04343314696445828 0.014466631695754675 4.273573704726852e-11 10.3692088015258 -0.25336818658744753 FLNAENAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLNAENAQK 9 0 P43487-2;P43487;F6WQW2;C9JXG8;C9JGV6 P43487-2 RANBP1 Ran-specific GTPase-activating protein 0 5469280.0 1461200.0 645480.0 3362600.0 False True 1414815.0058204415 903223.5301337319 2481834.1841623187 1.0 0.6384039796142527 1.754175757220726 20.432181995078647 -6.819477378832308 1.374367476918463 0.8050035655954224 1.7782156810073728 0.8831251648633347 0.15890623046471203 0.19416385153412227 0.720828730870558 0.09086668597618161 0.20943890613064545 1.5153837336833878e-07 6.819477378832308 0.9732121154119504 FLNALTLNMIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLNALTLNMIR 11 0 Q6NVY1;Q6NVY1-2;B8ZZZ0 Q6NVY1 HIBCH 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial 0 4187990.0 1296000.0 2260400.0 631590.0 False True 1699068.5504818545 1923157.1309701889 566239.1254390816 1.0 1.1318890755907307 0.3332644379054021 20.696312629877585 -6.864487178685631 1.1627614259793508 1.0726130084981529 0.2911240625836635 0.9588702084071663 0.0708925337498481 0.14225579416392523 0.36294020709345687 0.047456120280425285 0.11140565706403224 1.3661954081445123e-07 6.864487178685631 -0.7814889459144894 down FLNALTLNMIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLNALTLNMIR 11 0 Q6NVY1;Q6NVY1-2;B8ZZZ0 Q6NVY1 HIBCH 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial 0 15064100.0 1296000.0 7119700.0 6648400.0 False True 1775166.2230831056 6805128.112300541 5078184.848096041 1.0 3.8335159963112675 2.8606813165227187 20.759522691400477 -10.507934369928368 5.791466429016862 0.9966829702196481 3.347098656416967 0.8858590953351377 0.39715809492763754 0.01700050632227631 0.001444427188750417 0.3843327505451624 0.12818222395551662 3.105028780975235e-11 10.507934369928368 2.350415686197319 FLNEFFLNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLNEFFLNVK 10 0 B4DKY1;P49589-2;P49589;P49589-3 B4DKY1 CARS Cysteine--tRNA ligase, cytoplasmic 0 3261900.0 2232200.0 0.0 1029700.0 False True 2161340.032844506 0.0 759990.679662148 1.0 0.0 0.3516293910782451 21.043494631390875 -10.567845142840246 6.339772674342614 1.0015005874574652 0.17581469553913925 0.8798824358850987 0.1435520977845427 0.0030487875215703102 0.000207822250987729 0.13917971705473922 0.04633124033605605 2.7049226912920247e-11 10.567845142840246 -0.8256858919183259 FLNEFFLNVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLNEFFLNVK 10 0 B4DKY1;P49589-2;P49589;P49589-3 B4DKY1 CARS Cysteine--tRNA ligase, cytoplasmic 0 14907200.0 2934100.0 4717500.0 7255600.0 False True 4451244.2114426615 3875625.2670042627 5821527.47975755 1.0 0.8706835848370945 1.3078427520989184 22.08577722378145 -6.827463760873601 1.3391773075570488 0.9307713938256416 1.3190109279112843 0.9007134515519458 0.05777726770474953 0.1839601187253021 0.6461069640705841 0.03388321512539556 0.07798864609451624 1.487771514018651e-07 6.827463760873601 0.3882395340856427 FLNEFFLNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLNEFFLNVK 10 0 B4DKY1;P49589-2;P49589;P49589-3 B4DKY1 CARS Cysteine--tRNA ligase, cytoplasmic 0 2943450.0 513250.0 1085400.0 1344800.0 False True 703012.395059724 1037443.4390621817 1027185.9370253818 1.0 1.475711447412028 1.4611206633677034 19.42319060062445 -10.24003574496294 5.19679114763568 0.9999473699277138 1.4684160553899661 0.9992728241248089 0.005956662643060275 3.6328274944532645e-06 5.31241930360064e-07 0.0057681594652920455 0.001922504601232754 5.7539257723096825e-11 10.24003574496294 0.4684686854622523 FLNEFFLNVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLNEFFLNVK 10 0 B4DKY1;P49589-2;P49589;P49589-3 B4DKY1 CARS Cysteine--tRNA ligase, cytoplasmic 0 10146300.0 2934100.0 4496200.0 2716000.0 False True 3798250.2897576815 4245982.517522549 2221715.868513361 1.0 1.1178785476492208 0.5849314023629287 21.856903545873898 -6.848692124306327 1.2413625917005262 1.062840843967302 0.5641547545904531 0.9383864856030693 0.056736513219562586 0.1588987101791546 0.4718485167932462 0.03577583184832716 0.08272238652830578 1.4167978061412488e-07 6.848692124306327 -0.498686089376849 FLNEHLQEACTPELK(ub)PVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLNEHLQEACTPELKPVEK 19 1 Q8N3C0;Q8N3C0-4 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 1 41377600.0 17610000.0 16762000.0 7005600.0 True False 23086880.5354826 14261174.937764272 6280727.714460381 1.0 0.6177177083688739 0.27204748189377204 24.46056991571153 -7.61230596045703 0.29011200124034026 1.103218558656868 7.809418050521513e-12 0.9996501544245955 0.005560942489828144 0.1270988238316207 0.0356071848826313 0.030024854103873403 0.07280185345687698 2.4417097621200223e-08 7.61230596045703 -1.1032185586490586 down FLNEHLQEACTPELK(ub)PVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLNEHLQEACTPELKPVEK 19 1 Q8N3C0;Q8N3C0-4 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 1 97750000.0 31397000.0 33532000.0 32821000.0 True False 47631544.428160414 27547952.613288224 26333914.96404468 1.0 0.5783552253871806 0.5528671236718437 25.505413992311425 -13.999999999999977 0.39923114322497455 8.072545794899158 0.5513438103378908 0.9998366782857112 0.0026203136513340266 26.657349682671086 0.20815426511335935 163.27142759612025 0.006535816931669441 1.0000000000000532e-14 13.999999999999977 -7.521201984561267 FLNEHLQEACTPELK(ub)PVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLNEHLQEACTPELKPVEK 19 1 Q8N3C0;Q8N3C0-4 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 1 37071700.0 17610000.0 10400000.0 9061700.0 True False 24120892.892356083 9940493.611799046 6921513.091569674 1.0 0.41211134497219176 0.28695094839391716 24.523779977234422 -13.999999999999886 0.2174163256156177 4.507921964793735 0.21832214351059384 0.9994954397714062 0.006982711841368475 12.930626468659117 0.1477347465220844 19.448425972915945 0.07046653352001528 1.0000000000002617e-14 13.999999999999886 -4.289599821283141 FLNEHLQEACTPELK(ub)PVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLNEHLQEACTPELKPVEK 19 1 Q8N3C0;Q8N3C0-4 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 1 19358900.0 7684400.0 4892400.0 6782100.0 True False 6389919.0766406655 4866043.670134633 8200205.753112634 1.0 0.7615188254767116 1.2833035371433341 22.607366230000597 -6.782420174921979 1.5262172915725953 0.8653891617432373 1.2877707484834262 0.7759160137053234 0.10096122249330751 0.24684175366418726 1.1357905977207512 0.05209151349951791 0.12267936469396194 1.6503643170642426e-07 6.782420174921979 0.4223815867401889 FLNEHLQEACTPELK(ub)PVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLNEHLQEACTPELKPVEK 19 1 Q8N3C0;Q8N3C0-4 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 1 107762000.0 31397000.0 50413000.0 25952000.0 True False 40644035.427395836 47607472.23341138 21229002.290006895 1.0 1.171327397311584 0.5223153180232106 25.276540314403874 -6.836513608747644 1.2983916657326644 1.0912244016894426 0.5023878919858212 0.9183093802714474 0.07849112112872751 0.17290897401803448 0.5677134895973646 0.04742702742227138 0.1091875082295578 1.4570900456621327e-07 6.836513608747644 -0.5888365097036213 FLNEQK(ub)NLHSEISGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLNEQKNLHSEISGK 15 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 14770100.0 5529400.0 5264400.0 3976300.0 True False 5353872.223640533 7366502.37348332 2934787.743556957 1.0 1.3759204676114283 0.5481617081928333 22.352151277126193 -6.783237609629683 1.5232877055626632 1.2119607924968043 0.5409296428801696 0.778669671073601 0.15920497184294266 0.2455756815693435 1.1257073196870073 0.08230143391502005 0.19367545021392027 1.6472609014981178e-07 6.783237609629683 -0.6710311496166347 FLNEQK(ub)NLHSEISGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLNEQKNLHSEISGK 15 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 13124730.0 4735200.0 4633100.0 3756430.0 True False 6485931.403968454 4428394.322387133 2869238.6001042956 1.0 0.6827692194952284 0.4423788075138654 22.628882335073204 -7.57503996531708 0.16889362694432866 1.2637644451650518 1.2604354326039087e-12 0.9999694606164364 0.0012620000344315064 0.133709710553003 0.01726111101641768 0.04272566133787891 0.0738865198228927 2.660480221716547e-08 7.57503996531708 -1.2637644451637915 down FLNEQK(ub)NLHSEISGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLNEQKNLHSEISGK 15 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 17901500.0 5529400.0 10086100.0 2286000.0 True False 4597941.093953577 10031764.177365892 2763992.0307302256 1.0 2.181794845209728 0.6011368945907014 22.13255655256047 -6.70655101449679 1.8073386909325306 1.7290643532547507 0.6051832678949344 0.44884245161185 0.4982757669090554 0.38201847928700433 2.4302272934310856 0.21957056555019755 0.5601914064727995 1.96539110192268e-07 6.70655101449679 -1.1238810853598165 FLNLWLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLNLWLK 7 0 O60566;O60566-3 O60566 BUB1B Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 0 2508670.0 759640.0 1136100.0 612930.0 False True 995895.3963642238 966598.3084831152 549509.8832397225 1.0 0.9705821635604851 0.5517746996781507 19.925634691557704 -6.92107790285977 0.8167111893849166 1.0088869221191186 0.48253925835109596 0.9944746596582396 0.015216942160218195 0.09754196040405681 0.1023646035026168 0.013186262686584573 0.03991431899004949 1.1992841587036927e-07 6.92107790285977 -0.5263476637680227 FLNLWLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLNLWLK 7 0 O60566;O60566-3 O60566 BUB1B Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 0 3174140.0 759640.0 1099000.0 1315500.0 False True 1040499.4364991114 1050442.5460929964 1004805.99357294 1.0 1.0095560932039904 0.9656958555919393 19.988844753080595 -6.849631413900232 1.2368564792390702 1.0050978629127272 0.9639547737218725 0.9397725105362977 0.004621623609706902 0.1578591527706358 0.46490188374890207 0.002924164500674601 0.006765165948885212 1.413736875314483e-07 6.849631413900232 -0.04114308919085463 FLNLWLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLNLWLK 7 0 O60566;O60566-3 O60566 BUB1B Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 0 10772200.0 1721400.0 6062400.0 2988400.0 False True 2228386.2338669044 5725022.110722102 2444541.8635733947 1.0 2.5691336733791914 1.0970009715646991 21.087567878030793 -6.631082893650956 2.076170939837431 2.032926090502999 1.1029015653477867 0.12154195974680826 0.6728843266437977 0.5561754584095402 4.569919405042841 0.2649253199158137 0.7455182359126784 2.338390868133013e-07 6.631082893650956 -0.9300245251552124 FLNSGGFIGFATTIHQIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLNSGGFIGFATTIHQIVR 19 0 O60568 O60568 PLOD3 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 0 38531400.0 18128000.0 9661400.0 10742000.0 False True 17552536.562765505 13519247.403535413 7928347.946907641 1.0 0.7702161653498003 0.4516924330883424 24.065176197424506 -6.9665353568311685 0.3306437002594062 1.0385162247492232 0.17295502816979297 0.9999413846111405 0.0017212331354929985 0.07744375005703355 0.013043455421423456 0.004637166481252781 0.02776798137522371 1.0801016839426937e-07 6.9665353568311685 -0.8655611965794303 down FLNSGGFIGFATTIHQIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLNSGGFIGFATTIHQIVR 19 0 O60568 O60568 PLOD3 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 0 141383200.0 45045100.0 41859100.0 54479000.0 False True 68336709.93792173 34389016.55835897 43711201.77100606 1.0 0.50322903443257 0.6396445162594758 26.026157455284192 -10.428857631923062 9.033520711699094 1.0000029688516012 0.5714367753460426 0.9293763128382655 0.05569138724863845 3.3299119693882856e-06 2.1054310228046768e-07 0.053923327264764426 0.017974317945097053 3.72513801708389e-11 10.428857631923062 -0.4285661935055586 FLNSGGFIGFATTIHQIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLNSGGFIGFATTIHQIVR 19 0 O60568 O60568 PLOD3 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 0 5193630.0 1320100.0 622330.0 3251200.0 False True 1808176.644361115 594833.4028298947 2483333.520565827 1.0 0.32896863516344543 1.3733909949065102 20.786104193700766 -6.7332250171604215 1.7117527372456371 0.5976300121401577 1.3731127925262088 0.5740498952345122 0.28202019606429485 0.33021445976620584 1.8970093744396992 0.1304935391581377 0.3226005208258413 1.848310721952228e-07 6.7332250171604215 0.7754827803860511 FLNSGGFIGFATTIHQIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLNSGGFIGFATTIHQIVR 19 0 O60568 O60568 PLOD3 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 0 39823500.0 18128000.0 12045000.0 9650500.0 False True 15074235.206566798 11980111.194254698 11668374.931129497 1.0 0.7947408959783111 0.7740608243956811 23.845581472858782 -13.999999999999844 0.3243934582523707 3.1604459145120978 0.7701535381980033 0.9997030858444981 0.0017573049074197846 18.361315369090793 0.1818488825565269 26.985259089015035 0.00676920400562121 1.0000000000003599e-14 13.999999999999844 -2.3902923763140946 FLNSGGFIGFATTIHQIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLNSGGFIGFATTIHQIVR 19 0 O60568 O60568 PLOD3 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 0 113958200.0 45045100.0 42578100.0 26335000.0 False True 58311769.92166731 40208591.305842035 21542300.219918758 1.0 0.6895450328442432 0.3694331392934471 25.79728377737664 -7.128100107199437 0.25870621623749895 1.0994734524317333 2.7463451922123405e-12 0.9999744770627679 0.0013005694267051774 0.07975504804586989 0.010865091422986039 0.008805409312633591 0.03327756628475181 7.445603289886141e-08 7.128100107199437 -1.099473452428987 down FLNTPSDK(ub)SEDGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLNTPSDKSEDGR 13 1 Q9BUB7;D4PHA6;Q9BUB7-3 Q9BUB7 TMEM70 Transmembrane protein 70, mitochondrial 1 9844400.0 1471600.0 2975100.0 5397700.0 True False 1929281.850994671 2531226.676848969 4839197.782394486 1.0 1.3120046070738478 2.5082896933382557 20.87963249307857 -6.945847990285661 0.6027063282180173 0.9866017126477041 2.895216166105466 0.9988338541043073 0.022199346347012445 0.08519706729002921 0.043201391638813716 0.022723750316703647 0.1006223767717892 1.1327967900646178e-07 6.945847990285661 1.9086144534577616 up FLNTPSDK(ub)SEDGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLNTPSDKSEDGR 13 1 Q9BUB7;D4PHA6;Q9BUB7-3 Q9BUB7 TMEM70 Transmembrane protein 70, mitochondrial 1 14920800.0 2609100.0 4136000.0 8175700.0 True False 2526275.5486491327 5787526.368955063 6034238.904257385 1.0 2.2909323458598205 2.388590946654277 21.268580576220337 -10.71004962604094 0.48780670596822284 1.477747886415022e-20 2.3858585268121972 0.9996666385323211 0.011554270733824087 2.254317600670447 0.23416696284374397 2.702548813281851 0.020304304153401998 1.9496218072895564e-11 10.71004962604094 2.3858585268121972 FLNTPSDK(ub)SEDGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLNTPSDKSEDGR 13 1 Q9BUB7;D4PHA6;Q9BUB7-3 Q9BUB7 TMEM70 Transmembrane protein 70, mitochondrial 1 42722200.0 6270200.0 11751000.0 24701000.0 True False 9512351.813021973 9653942.239017945 19818836.523167122 1.0 1.0148849021544957 2.0834843908985836 23.181370643271915 -6.909933652908804 0.8961764185676048 0.9668442014900339 2.221391747865226 0.9908966828349542 0.04840095572311332 0.10446234630723109 0.13900179350688777 0.039613448644185124 0.109302257354948 1.2304567331120452e-07 6.909933652908804 1.2545475463751918 up FLNTPSDK(ub)SEDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLNTPSDKSEDGR 13 1 Q9BUB7;D4PHA6;Q9BUB7-3 Q9BUB7 TMEM70 Transmembrane protein 70, mitochondrial 1 9286100.0 1471600.0 1954600.0 5859900.0 True False 2015690.2884946717 1868239.3090021585 4475912.308428797 1.0 0.9268483951457491 2.220535731097575 20.942842554601462 -6.893504789218621 1.0014018377151341 0.9362158157504628 2.339763702478339 0.9830489591328356 0.0772532041634908 0.1163461983853823 0.20559734840574026 0.058492395298408134 0.14779059072617023 1.2778951173935977e-07 6.893504789218621 1.4035478867278763 up FLNTPSDK(ub)SEDGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLNTPSDKSEDGR 13 1 Q9BUB7;D4PHA6;Q9BUB7-3 Q9BUB7 TMEM70 Transmembrane protein 70, mitochondrial 1 14041500.0 2609100.0 6473500.0 4958900.0 True False 2169582.2527280133 6438625.970610854 5995783.062636972 1.0 2.967680051085864 2.763565684176264 21.048985851654614 -9.729453840159987 6.429924616886992 0.9999999874034685 2.865622867632675 0.9911022710337689 0.08332934135573214 1.4952046173217022e-08 2.804717328952083e-09 0.08068328963115212 0.026894429275914313 1.8644303323529552e-10 9.729453840159987 1.8656228802292065 FLNTPSDK(ub)SEDGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLNTPSDKSEDGR 13 1 Q9BUB7;D4PHA6;Q9BUB7-3 Q9BUB7 TMEM70 Transmembrane protein 70, mitochondrial 1 39904200.0 6270200.0 13989000.0 19645000.0 True False 8116897.504120041 13210499.852680715 16069811.574722013 1.0 1.6275306970397523 1.979797276800054 22.952496965364364 -9.571991247015786 0.1410030484305404 3.433141873901575e-19 2.592757031852731 0.999815913531888 0.0054980714527760296 1.0419367560643942 0.05772204759209417 0.7260522810304852 0.3187739328010305 2.6792223226369886e-10 9.571991247015786 2.592757031852731 FLNVPMFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLNVPMFR 8 0 O14980 O14980 XPO1 Exportin-1 0 7630800.0 2439800.0 3307700.0 1883300.0 False True 3198601.4270568113 2814204.053313613 1688434.1818892334 1.0 0.8798232969911162 0.5278663879803379 21.609009800904605 -6.95199057076135 0.5365470617697111 1.0053027075287855 0.38622948696612946 0.9993483705652568 0.005114091202824296 0.0826961701627807 0.03272972525088391 0.005651979772011833 0.029131488557812283 1.116887496959096e-07 6.95199057076135 -0.619073220562656 FLNVPMFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLNVPMFR 8 0 O14980 O14980 XPO1 Exportin-1 0 4979900.0 1434900.0 753000.0 2792000.0 False True 1389349.8849245491 1053676.826843126 2060691.4417953936 1.0 0.7583955908272505 1.4832055367444772 20.40597853342409 -6.8168375648136434 1.3854059467958368 0.8693391609665633 1.497990670772211 0.8769523299639634 0.1057017576056281 0.19764024409027167 0.7462061171205482 0.05996644768443489 0.13834943773987132 1.524622887900834e-07 6.8168375648136434 0.6286515098056478 FLNVPMFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLNVPMFR 8 0 O14980 O14980 XPO1 Exportin-1 0 6857700.0 2439800.0 1980300.0 2437600.0 False True 3341859.993115864 1892803.7980236209 1861889.0839478509 1.0 0.5663923090502722 0.5571415582290368 21.672219862427497 FLPFLTKPAGFSLDWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLPFLTKPAGFSLDWK 16 1 Q9NZJ4;Q9NZJ4-2 Q9NZJ4 SACS Sacsin 0 13694800.0 4857300.0 3134400.0 5703100.0 False True 7368879.216195915 2575041.8308210215 4575879.785242468 1.0 0.3494482342934035 0.6209736448366845 22.81301377586347 -10.38637284085426 5.944069979549985 1.0001159275170004 0.48521093956513095 0.8273676639902433 0.11084978467179442 0.0001703348718812506 1.7584387910605872e-05 0.1073537391044244 0.03577661416371129 4.1079690144544756e-11 10.38637284085426 -0.5149049879518695 FLPFLTKPAGFSLDWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLPFLTKPAGFSLDWK 16 1 Q9NZJ4;Q9NZJ4-2 Q9NZJ4 SACS Sacsin 0 9441000.0 4857300.0 2534300.0 2049400.0 False True 6287870.601697278 2393263.977171255 1676430.228619765 1.0 0.3806159714109326 0.2666133473178103 22.58414009795592 -13.999999999999988 0.23802486902474848 5.060845556683156 0.2152534796132341 0.9995217413836764 0.007046884186362275 13.55453517960647 0.15442493524583456 26.13296555602526 0.0563599741120977 1.0000000000000286e-14 13.999999999999988 -4.845592077069922 FLPGMAIGYSSSK ddPTM_RPMI8226_Bortezomib_1h_R1 2 FLPGMAIGYSSSK 13 0 P19623;K7EQ47 P19623 SRM Spermidine synthase 0 316370200.0 77906100.0 121792000.0 116672100.0 False True 102135651.54374565 103621108.34149781 104599990.28980993 1.0 1.0145439596781338 1.024128095418364 26.60591130139169 FLPGMAIGYSSSK ddPTM_RPMI8226_Bortezomib_2h_R1 2 FLPGMAIGYSSSK 13 0 P19623;K7EQ47 P19623 SRM Spermidine synthase 0 252875100.0 98270600.0 32263900.0 122340600.0 False True 95151053.59360693 45147043.5240158 90295926.7206712 1.0 0.47447759976300635 0.9489745337590046 26.50371629554905 -10.42023248029555 8.770802355693853 1.0000023701675402 0.7117260667610058 0.3298185435381037 0.19371256213421076 8.978037456369379e-06 5.935094373966584e-07 0.1875629227299673 0.06252046059141399 3.799859332460449e-11 10.42023248029555 -0.28827630340653443 FLPGMAIGYSSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FLPGMAIGYSSSK 13 0 P19623;K7EQ47 P19623 SRM Spermidine synthase 0 270845400.0 77906100.0 83378700.0 109560600.0 False True 106710090.50319035 79694753.3375106 83684642.75138536 1.0 0.7468342774494033 0.7842242692961019 26.66912136291458 -10.371659920899432 4.953035500981218 1.0001810914352822 0.765529273372703 0.9812849942245535 0.015264400252044017 3.054810078778229e-05 3.8753135200930964e-06 0.014791043268807492 0.004926563997143062 4.249521972143819e-11 10.371659920899432 -0.23465181806257918 FLPGMAIGYSSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLPGMAIGYSSSK 13 0 P19623;K7EQ47 P19623 SRM Spermidine synthase 0 176720000.0 89991000.0 37770000.0 48959000.0 False True 74831503.77725919 37566525.513242014 59196100.539160654 1.0 0.5020148415707535 0.791058545547363 26.157142431311986 -10.224551958713704 5.712519667726455 1.0000131396001228 0.6465366935590521 0.6659859742924024 0.118001598017822 1.974763305511204e-05 2.6805687189969138e-06 0.11425879957210766 0.038084851995736455 5.962769773707958e-11 10.224551958713704 -0.35347644604107076 FLPGMAIGYSSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FLPGMAIGYSSSK 13 0 P19623;K7EQ47 P19623 SRM Spermidine synthase 0 255124800.0 59991900.0 114999000.0 80133900.0 False True 77660697.16714297 108599204.55775446 65550352.44324854 1.0 1.398380500293797 0.8440608291497783 26.210681322720678 -6.713908535553035 1.7821160526732613 1.2439440045003343 0.8452553083602649 0.4832851001098507 0.1677770987156233 0.3672594412814748 2.2761887427613336 0.07486698141241019 0.18924138560355663 1.9323752414194636e-07 6.713908535553035 -0.3986886961400694 FLPLFDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLPLFDR 7 0 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 0 46574000.0 11898000.0 16156000.0 18520000.0 False True 15598393.220395887 13745587.775594765 16603728.056384351 1.0 0.8812181858334959 1.064451179155679 23.894894089942962 -6.731715452369409 1.7167911696863019 0.9286535328641815 1.0643798543238596 0.5672178367877826 0.049926950575675734 0.33306400589574076 1.9239027421615302 0.023037676299403585 0.0570597630518566 1.8547464462418503e-07 6.731715452369409 0.1357263214596781 FLPLFDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLPLFDR 7 0 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 0 25977200.0 11385000.0 5515200.0 9077000.0 False True 11023589.40683392 7717448.121388042 6699461.395836957 1.0 0.7000848667861049 0.6077386546784588 23.394090722627976 -13.999999999999998 0.16497539528905855 2.493626468357549 0.5217632250376003 0.9995241736711252 0.0036525867626036644 12.046596254621111 0.12850713596797697 5.756622162872388 0.07887781370990227 1.0000000000000041e-14 13.999999999999998 -1.9718632433199488 FLPLFDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLPLFDR 7 0 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 0 43436000.0 11898000.0 17423000.0 14115000.0 False True 16297012.13136015 16653194.24984373 10781327.707550017 1.0 1.021855669960396 0.6615524134515206 23.958104151465854 -6.892472170813237 1.0076142125318999 1.0182277606519528 0.6290158240415107 0.9824350231216675 0.02185980369316939 0.11716136712394991 0.21030042832780907 0.016473803717256475 0.04145357485818802 1.2809371731700307e-07 6.892472170813237 -0.38921193661044207 FLPLFDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLPLFDR 7 0 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 0 27357700.0 11385000.0 12169000.0 3803700.0 False True 9467131.941017376 12103443.181642635 4599036.083678283 1.0 1.2784698953231184 0.4857897948746716 23.174495998062252 -6.811784849389797 1.4071214923706556 1.1514433927417016 0.47136062869616596 0.8644205931716924 0.12090060716734623 0.2043706653074365 0.7972058582480903 0.06755516000893226 0.15613878703615472 1.542464404559744e-07 6.811784849389797 -0.6800827640455356 down FLPLFDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLPLFDR 7 0 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 0 93947000.0 25155000.0 36571000.0 32221000.0 False True 32563643.379180882 34535791.7015073 26357108.615378875 1.0 1.0605628890895937 0.8094029377630985 24.9567587886012 -6.843035283161991 1.2683359232736982 1.0322152019568405 0.8006391077384502 0.9295293079589294 0.028409440354344128 0.16528551897410032 0.5151957821322114 0.017554875100251548 0.040479448686317254 1.4353728153652391e-07 6.843035283161991 -0.23157609421839032 FLPVFDIVIHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLPVFDIVIHR 11 0 Q5JWT2;Q9ULK4-4;Q9ULK4-5;Q9ULK4-3;Q9ULK4 Q5JWT2 MED23 Mediator of RNA polymerase II transcription subunit 23 0 1584480.0 365830.0 708200.0 510450.0 False True 479606.67270275956 602539.3205419789 457633.5305821489 1.0 1.2563197195452867 0.9541850783751945 18.871492205349526 -6.681909186611191 1.8949922161666228 1.1618980439220084 0.9553148629918607 0.33290040783308106 0.10858942527205755 0.43431513821815243 3.01697256848018 0.045951930763929484 0.12090446145842769 2.0801316087050198e-07 6.681909186611191 -0.2065831809301476 FLPVFDIVIHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLPVFDIVIHR 11 0 Q5JWT2;Q9ULK4-4;Q9ULK4-5;Q9ULK4-3;Q9ULK4 Q5JWT2 MED23 Mediator of RNA polymerase II transcription subunit 23 0 1328930.0 365830.0 543230.0 419870.0 False True 501087.2371840217 519228.30237861496 320705.3534940862 1.0 1.0362034070086106 0.6400190020731037 18.934702266872417 -6.884563788210661 1.053969989243337 1.024143230263512 0.6093581672021054 0.9771860154930313 0.02701277986977018 0.12366636703841899 0.24848265205851994 0.019654065082898076 0.04813252266878266 1.3044763559733063e-07 6.884563788210661 -0.4147850630614066 FLQDYFDGNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLQDYFDGNLK 11 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 15471400.0 3501700.0 5657700.0 6312000.0 False True 4590762.61051104 4813593.213541875 5658894.788979372 1.0 1.0485389077885752 1.2326698784255865 22.130302401179897 -6.946094065782477 0.6002009746707332 0.9979269484270826 1.2927107436487266 0.9988579719293833 0.0033868030284652673 0.08509322770986608 0.042753884722555834 0.0034753294576945794 0.01547489110536731 1.1321551181410863e-07 6.946094065782477 0.294783795221644 FLQDYFDGNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLQDYFDGNLK 11 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 15713900.0 3501700.0 6281100.0 5931100.0 False True 4796373.119884344 6003580.233179914 4530296.334838824 1.0 1.2516916601610593 0.9445254198547557 22.193512462702788 -6.688899475500125 1.8700611819876745 1.1579529052567192 0.9455925560553121 0.365427443699898 0.10647107661176475 0.41902222603862826 2.8401712709573523 0.045558828097339896 0.11881478685172767 2.0469183743437375e-07 6.688899475500125 -0.21236034920140712 FLQDYFDGNLKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLQDYFDGNLKR 12 1 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 12173700.0 4459100.0 3971800.0 3742800.0 False True 5845923.281985821 3379222.9219551412 3355530.959472746 1.0 0.5780477708915882 0.573995038527583 22.47899946562092 FLQDYFDGNLKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLQDYFDGNLKR 12 1 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 32108600.0 2542800.0 25915000.0 3650800.0 False True 3857613.5035807947 21290265.775180817 2929217.7797975186 1.0 5.519025105915437 0.7593341782629335 21.879277175541848 -6.657903059948632 1.9802240482664235 3.913841011993281 0.77919960891859 0.22676391028021448 1.925065470684698 0.4894397671874742 3.6871684069471824 0.7860003825177019 2.1337115288623143 2.1983505178161094e-07 6.657903059948632 -3.134641403074691 FLQDYFDGNLKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLQDYFDGNLKR 12 1 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 11615500.0 4459100.0 4858500.0 2297900.0 False True 6107749.772646499 4643835.405089007 1755183.3467360414 1.0 0.7603185424992983 0.28736988450257306 22.54220952714381 -6.960307531853656 0.4310787996045485 1.0185726984820889 0.010946616987668677 0.9997814326707952 0.004377246930552019 0.07959146509196172 0.020726846204855813 0.006173619132827379 0.039259636410984164 1.0957020347482392e-07 6.960307531853656 -1.0076260814944202 down FLQDYFDGNLKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLQDYFDGNLKR 12 1 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 14053500.0 2542800.0 5792200.0 5718500.0 False True 3291704.7260815385 5469858.978247 4677791.676764974 1.0 1.6617100965669989 1.4210848378048297 21.650403497634297 -10.327677221692557 5.334000056803794 0.9998596066678119 1.5413974671859385 0.8709638535575319 0.09823485053216506 0.000164050655515695 2.0677678356228414e-05 0.09513986172307859 0.031705161677341914 4.702434752409354e-11 10.327677221692557 0.5415378605181266 FLQEFYQDDELGK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLQEFYQDDELGKK 14 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 86146300.0 32224300.0 34120000.0 19802000.0 True False 42246369.36056513 29029428.998718347 17753078.99419671 1.0 0.6871461249357883 0.42022732989614764 25.3323240261845 -7.272377382768935 0.1998955598115537 1.1796815508109564 2.0627226641456902e-13 0.9999815776673908 0.0010169540190769534 0.10269724119212673 0.011471852916511826 0.01767383150428222 0.04426626817758848 5.341000482847405e-08 7.272377382768935 -1.17968155081075 down FLQEFYQDDELGK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLQEFYQDDELGKK 14 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 94535000.0 31125000.0 27536000.0 35874000.0 True False 30136953.911963638 38531268.39834298 26477523.203068756 1.0 1.2785389164047865 0.8785733050664362 24.84503026833416 -6.7194786094997845 1.7616542237824155 1.169557723618301 0.8792343465321597 0.5098717551263596 0.11721764076488932 0.356318597843281 2.160925914081848 0.05284361835957547 0.13271547047993448 1.9077496849239574e-07 6.7194786094997845 -0.2903233770861413 FLQEFYQDDELGK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLQEFYQDDELGKK 14 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 502129100.0 61784100.0 53502000.0 386843000.0 True False 93730996.72274104 43954150.08696605 310383311.49068993 1.0 0.4689393223565485 3.31142655410795 26.48202288843686 -6.858415485352322 1.1937438853765887 0.7130035239171285 3.444948726821502 0.9516842865703083 0.27124002626027727 0.14844060825045405 0.40285907804203647 0.1773322226597369 0.41322840241252623 1.3854297673292206e-07 6.858415485352322 2.731945202904374 up FLQEFYQDDELGK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLQEFYQDDELGKK 14 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 102137100.0 32224300.0 34677800.0 35235000.0 True False 44138494.53896366 33145620.13185047 26913218.687603615 1.0 0.7509458688626289 0.6097448263407744 25.395534087707393 -13.999999999560938 0.06553766497766013 2.498753810481048 0.04661857132149442 0.9999387410644273 0.0012627356552489543 12.406718519959856 0.06756282655359516 2.9274097025402157 0.5225548671420389 1.000000001010978e-14 13.999999999560938 -2.4521352391595532 FLQEFYQDDELGK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLQEFYQDDELGKK 14 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 116324900.0 31125000.0 52388200.0 32811700.0 True False 25881816.571292583 52105974.368356496 39672474.7658403 1.0 2.013227094196744 1.5328319268688406 24.625435543768436 -10.172131552920392 4.719698785444505 0.9999043012569643 1.7730295105379434 0.7754070490909357 0.19612050582639323 137491787.72335005 26.454281783897613 142992.47774512882 0.06713726564136771 6.727728345899784e-11 10.172131552920392 0.7731252092809792 FLQEFYQDDELGK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLQEFYQDDELGKK 14 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 676589100.0 61784100.0 51506000.0 563299000.0 True False 79980735.39668639 48639645.82258721 460784361.93582827 1.0 0.6081420179665209 5.761191862645947 26.25314921052931 -6.888559267357648 1.0308899258839146 0.7134806551246655 6.192054798303795 0.9799591774578853 0.3315861103983878 0.12031901012505382 0.22874929064052324 0.24553602566710414 0.6090224449404232 1.2925302995720567e-07 6.888559267357648 5.47857414317913 up FLQFFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLQFFK 6 0 Q92973-2;Q92973;Q92973-3;O14787-2;O14787;A0A075B780 Q92973-2;O14787-2 TNPO1;TNPO2 Transportin-1;Transportin-2 0 6419300.0 1941200.0 1969600.0 2508500.0 False True 2544931.998607538 1675743.3574406689 2248944.483231108 1.0 0.658462920957241 0.8836953146337977 21.279195676869794 -10.526990833239722 5.02961300523586 1.0009563841151128 0.7710791177955141 0.5793655627715704 0.09195073967555636 0.0009901047676771108 9.311412463515952e-05 0.08939189616245026 0.029676973619570977 2.971728756084667e-11 10.526990833239722 -0.2298772663195987 FLQFFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLQFFK 6 0 Q92973-2;Q92973;Q92973-3;O14787-2;O14787;A0A075B780 Q92973-2;O14787-2 TNPO1;TNPO2 Transportin-1;Transportin-2 0 5098200.0 1941200.0 2016200.0 1140800.0 False True 2658914.0989574986 1927117.617318195 871366.5355135009 1.0 0.7247761851628736 0.32771518863852894 21.342405738392685 -6.971913548781131 0.34337127995584615 1.0415866426860292 9.050017645820165e-20 0.9999308252009637 0.0022951688771082183 0.07682659578596426 0.013784019911660712 0.005533748750976639 0.033939227184528985 1.0668084603613043e-07 6.971913548781131 -1.0415866426860292 down FLQFFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLQFFK 6 0 Q92973-2;Q92973;Q92973-3;O14787-2;O14787;A0A075B780 Q92973-2;O14787-2 TNPO1;TNPO2 Transportin-1;Transportin-2 0 11280100.0 2526100.0 4290500.0 4463500.0 False True 3270086.2468753243 4051729.9033473865 3651188.799377537 1.0 1.2390284529097508 1.1165420492705258 21.640897255903326 -10.201912508106561 4.221946867102748 0.9999240701328433 1.177785251101091 0.7374650973236412 0.050004864927478784 35158929.2496521 3.5720393311467866 25952.33960495965 0.017117995310716956 6.281848986444955e-11 10.201912508106561 0.17786118096824755 FLQFVTGTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLQFVTGTSK 10 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 8864700.0 3236300.0 2044400.0 3584000.0 False True 4242820.640373785 1739383.4890087857 3213162.0601555873 1.0 0.4099592314737936 0.7573174386821389 22.01659226121877 -10.279044532916156 6.10194742745199 1.0000166049808406 0.583638335078 0.6570279313560619 0.14180839427140138 3.2035235134433626e-05 3.7848821856841663e-06 0.13731085502464838 0.0457684624471291 5.2596333090954215e-11 10.279044532916156 -0.41637826990284055 FLQFVTGTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLQFVTGTSK 10 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 9213100.0 3236300.0 2471500.0 3505300.0 False True 4432847.567719024 2362300.9578424385 2677420.333919598 1.0 0.5329082315045608 0.6039955791435656 22.07980232274166 -10.65042698700068 6.624043804212862 1.0020866146516623 0.5684519053241 0.980054824351594 0.029021288147234044 0.0008977149663886741 4.737536609557424e-05 0.028206994887414193 0.00936658047331034 2.2365211680235755e-11 10.65042698700068 -0.4336347093275623 FLQFVTGTSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLQFVTGTSK 10 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 5713000.0 2190600.0 1973400.0 1549000.0 False True 1821580.9600344894 1962768.9025107706 1872888.7382332117 1.0 1.0775084641165815 1.0281666197245225 20.796759686306945 -10.197263344399591 4.78345592583045 0.999992360108703 1.0528375419207456 0.6045789037686831 0.020143723622057953 1.641454837743463e-06 2.7549582911569073e-07 0.01950689654290081 0.006501358843141717 6.349458011774394e-11 10.197263344399591 0.052845181812042674 FLQHGTLVGLLPVPHPILIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLQHGTLVGLLPVPHPILIR 20 0 Q8IV36-2;Q8IV36;Q8IV36-3 Q8IV36-2 HID1 Protein HID1 0 7802200.0 2383700.0 2261700.0 3156800.0 False True 1982152.1658149457 2249515.7731876993 3816872.284605937 1.0 1.1348855108017548 1.9256202174754131 20.918636288881878 -6.936328646034352 0.6928792515660885 0.9903140330462654 2.117638115218175 0.9976423704577051 0.019824177654101664 0.0894821358430627 0.06254097771652646 0.018797558352175562 0.06922896467180614 1.1579007999423906e-07 6.936328646034352 1.1273240821719095 FLQHSNQK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLQHSNQKLK 10 1 P36956;P36956-4;P36956-3;P36956-2;P36956-6;P36956-5 P36956 SREBF1 Sterol regulatory element-binding protein 1;Processed sterol regulatory element-binding protein 1 1 6182260.0 741560.0 1829400.0 3611300.0 True False 718019.5837094217 2559888.960194967 2665392.193322243 1.0 3.565207716160203 3.712144144526442 19.453663667977008 -10.280542093543689 0.5979539023450309 4.424951321594528e-20 3.6954177242179798 0.9997297154482451 0.020473628560920037 1.5954893109582355 0.28846689490921584 2.683410875629567 0.0255589204906475 5.2415279557852357e-11 10.280542093543689 3.6954177242179798 FLQHSNQK(ub)LK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLQHSNQKLK 10 1 P36956;P36956-4;P36956-3;P36956-2;P36956-6;P36956-5 P36956 SREBF1 Sterol regulatory element-binding protein 1;Processed sterol regulatory element-binding protein 1 1 6646980.0 678480.0 1311700.0 4656800.0 True False 1029303.7635321293 1077616.8866411226 3736381.438852049 1.0 1.0469376726489403 3.6300085273470577 19.97323737611349 -6.910839027197626 0.8900034051568204 0.9221294460613124 3.969886040325779 0.9912343025143919 0.11505463781814652 0.10386581600220623 0.13577778039041533 0.09458924651400555 0.26265162446105195 1.227894270223403e-07 6.910839027197626 3.0477565942644667 up FLQHSNQK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLQHSNQKLK 10 1 P36956;P36956-4;P36956-3;P36956-2;P36956-6;P36956-5 P36956 SREBF1 Sterol regulatory element-binding protein 1;Processed sterol regulatory element-binding protein 1 1 5941260.0 741560.0 2858200.0 2341500.0 True False 616639.9966781598 2842802.309291718 2831096.8241272196 1.0 4.610149073374897 4.59116638456529 19.234068943411284 -10.220954609677209 4.324117537310953 0.9984594401828625 4.6006577290792245 0.9999791548862887 0.007749650621320296 284670.9991197412 336511.474397775 3436.729322795661 0.0026529114604236723 6.012365724884662e-11 10.220954609677209 3.602198288896362 FLQHSNQK(ub)LK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLQHSNQKLK 10 1 P36956;P36956-4;P36956-3;P36956-2;P36956-6;P36956-5 P36956 SREBF1 Sterol regulatory element-binding protein 1;Processed sterol regulatory element-binding protein 1 1 5324880.0 678480.0 1469100.0 3177300.0 True False 878305.734840256 1387343.2935573116 2599064.0018510716 1.0 1.5795676135595744 2.9591791317675757 19.74436369820594 -6.956503771948838 0.4821944954398959 0.9675597264233534 3.628919876254054 0.9996177268719945 0.016066896498349394 0.08097460453909501 0.02593250363995792 0.019539539178302062 0.1137983314650353 1.1053408691979769e-07 6.956503771948838 2.6613601498307005 FLQLCIFPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLQLCIFPR 9 0 Q8NI27;A0A0C4DG98;H0Y815 Q8NI27 THOC2 THO complex subunit 2 0 685780.0 685780.0 0.0 0.0 False True 939331.3985076628 0.0 0.0 1.0 0.0 0.0 19.841274708604427 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 FLQVHASSGHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLQVHASSGHK 11 0 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 0 25051900.0 10346000.0 6407100.0 8298800.0 False True 13563706.190806532 5451185.654680191 7440119.783710721 1.0 0.40189499669161216 0.5485314765040862 23.693248103196716 -10.244340573823775 8.331641059325339 1.0000002655215476 0.4752132365982632 0.9446821509284973 0.059864092203081275 2.95217920035866e-07 2.68498462768721e-08 0.05796318739950583 0.019321052678196584 5.6971732461000114e-11 10.244340573823775 -0.5247870289232844 FLQVHASSGHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLQVHASSGHK 11 0 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 0 13400900.0 5131100.0 2190300.0 6079500.0 False True 4968216.039122144 3064898.212263608 4487096.568909418 1.0 0.6169011548872094 0.9031605174927665 22.244296478750826 -10.292922166594009 5.658920868526735 1.0000239253296899 0.760030836189985 0.48373234559116673 0.11686489541300413 3.5279306582678426e-05 4.408284852436519e-06 0.11316521834750118 0.037717982807568225 5.094221605179223e-11 10.292922166594009 -0.23999308913970485 FLQVHASSGHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLQVHASSGHK 11 0 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 0 19158100.0 4410400.0 7290600.0 7457100.0 False True 6690899.243429572 5989535.468282204 5983200.916436966 1.0 0.8951764554164967 0.8942297139375455 22.67376868853963 FLQVHASSGHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLQVHASSGHK 11 0 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 0 24700400.0 10346000.0 5177200.0 9177200.0 False True 14171195.7901372 4948454.185289044 7009734.3703668555 1.0 0.349191011017789 0.49464663915274226 23.756458164719607 -10.086930237919828 7.640213629736028 1.000000061085872 0.421918825087362 0.954668781309434 0.05938201152444207 6.179235097234087e-08 7.3450801497100505e-09 0.0574963909935071 0.019165461808205088 8.18596271252103e-11 10.086930237919828 -0.5780812359985099 FLQVHASSGHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLQVHASSGHK 11 0 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 0 13048400.0 5131100.0 5115400.0 2801900.0 False True 4266736.99627179 5087842.324872597 3387764.3354781345 1.0 1.1924433892499764 0.7939941783236959 22.024701754185102 -6.775360280347501 1.553761837028376 1.109623615298751 0.791275392622167 0.7506812093659864 0.08123790145335226 0.2578578965837511 1.2291774632626675 0.04119332332750726 0.09759016282393225 1.6774118998499888e-07 6.775360280347501 -0.31834822267658414 FLQVHASSGHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLQVHASSGHK 11 0 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 0 22083100.0 4410400.0 9334100.0 8338600.0 False True 5709349.74198128 8814649.129666673 6821060.361261244 1.0 1.543897208617628 1.1947175544537887 22.44489501063208 -10.173926575483842 7.009173266737089 0.9999994038046254 1.369307381535708 0.598631815912509 0.14255199687715037 1.3340434740534798e-06 1.5728179153194794e-07 0.13802559958350544 0.046008459156151246 6.699978738337672e-11 10.173926575483842 0.3693079777310826 FLSAIVSSVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLSAIVSSVDK 11 0 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 14851800.0 6247400.0 4087300.0 4517100.0 False True 8190401.8999076625 3477490.772170614 4049713.8230828173 1.0 0.4245812128230019 0.49444628878693647 22.965502815424614 -10.428510516760326 6.002729158408064 1.0002005802020895 0.45951375080579937 0.98762333611501 0.028522297825404816 7.659156296386656e-05 7.291863569463769e-06 0.027626630848495527 0.009205532039446657 3.7281165692515156e-11 10.428510516760326 -0.5406868293962901 FLSAIVSSVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLSAIVSSVDK 11 0 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 16359700.0 6247400.0 5321600.0 4790700.0 False True 8557232.609636873 5086474.115822101 3659235.327563578 1.0 0.5944064334647023 0.4276190089121415 23.028712876947505 -13.999999999962682 0.12210626640345358 2.9305155106008844 0.1688170040734898 0.9996826722270965 0.004281645976424989 11.956185849083768 0.107808754196568 5.586111072217647 0.22970506772964117 1.0000000000859271e-14 13.999999999962682 -2.7616985065273947 FLSFPTTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLSFPTTK 8 0 G3V1N2 G3V1N2 HBA2 0 12368500.0 2549800.0 3530200.0 6288500.0 False True 3342812.492298324 3003507.92061182 5637826.343551458 1.0 0.8984972766291125 1.6865517753510653 21.672631001749366 -6.874531035276351 1.1097996785860433 0.9406710010612097 1.736869202792515 0.9690021028410796 0.06162696744951271 0.13258705915309915 0.3024731664311996 0.042964474040025485 0.10260403603697596 1.3349621879338973e-07 6.874531035276351 0.7961982017313053 FLSFPTTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLSFPTTK 8 0 G3V1N2 G3V1N2 HBA2 0 9840400.0 4188700.0 1821700.0 3830000.0 False True 4055732.011278455 2549114.310039999 2826808.102462883 1.0 0.6285213872492681 0.6969908501355373 21.951530896524215 -10.74656810575228 6.937477223761418 1.0058852657291855 0.6627561186924562 0.9700122296762865 0.02795254117229832 0.0025661663321082813 9.374412660866213e-05 0.027296120630888526 0.009021643870374043 1.7923874493977965e-11 10.74656810575228 -0.34312914703672925 FLSFPTTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLSFPTTK 8 0 G3V1N2 G3V1N2 HBA2 0 14392900.0 2549800.0 4112000.0 7731100.0 False True 3492529.965754088 3930318.243434392 5905173.407002483 1.0 1.1253498987762527 1.690801071116213 21.735841063272257 -6.9421251896240594 0.6394934699141182 0.9938120073494439 1.853313099896096 0.9984291492584515 0.011909647997714616 0.08681047199465797 0.05029525267420503 0.011789078183694795 0.048229999534847134 1.1425489364312382e-07 6.9421251896240594 0.8595010925466522 FLSGIINFIHFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLSGIINFIHFR 12 0 Q9BZD4;E9PQC4;B1AQT3;B1AQT4;E9PP32 Q9BZD4 NUF2 Kinetochore protein Nuf2 0 106698000.0 22445000.0 45650000.0 38603000.0 False True 34050705.949296415 37503400.834922016 30973100.12970405 1.0 1.1013986285854653 0.9096169746326227 25.02118137313879 -6.763114219706261 1.601326246655691 1.0586714371187913 0.9088207994850924 0.7033249204167134 0.04266882022349112 0.27772086292718445 1.40432112549404 0.021019543484004116 0.05034748026321666 1.72538405528353e-07 6.763114219706261 -0.14985063763369888 FLSGIINFIHFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLSGIINFIHFR 12 0 Q9BZD4;E9PQC4;B1AQT3;B1AQT4;E9PP32 Q9BZD4 NUF2 Kinetochore protein Nuf2 0 82832000.0 22445000.0 31098000.0 29289000.0 False True 29055494.95709459 29367368.962661017 23958702.53051835 1.0 1.0107337357710464 0.824584216028585 24.79230769523124 -6.893224965196869 1.0030871698969035 1.0092425240393372 0.8075228235666467 0.9828842134373232 0.011164061845935417 0.11656637150724312 0.206864500271356 0.008442143818898686 0.02130653506387324 1.278718754327421e-07 6.893224965196869 -0.2017197004726905 FLSHSLVELLNQISPTFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLSHSLVELLNQISPTFK 18 0 I3L2B0;A0A494C0R8;K7EIG1;O75153;I3L4B5 I3L2B0 CLUH Clustered mitochondria protein homolog 0 2147148700.0 938968700.0 634190000.0 573990000.0 False True 1424484165.7069776 521013839.5509132 460540624.9112458 1.0 0.36575614674686946 0.32330343572662845 30.407792439015534 -13.915298641108778 0.3847549648729627 9.99994997266765 0.3198472039196365 0.9998133895223911 0.004227624370290324 23.01856391439892 0.20254838514331652 171.47621288094786 0.01134998728667208 1.2153499819959645e-14 13.915298641108778 -9.680102768748014 FLSHSLVELLNQISPTFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLSHSLVELLNQISPTFK 18 0 I3L2B0;A0A494C0R8;K7EIG1;O75153;I3L4B5 I3L2B0 CLUH Clustered mitochondria protein homolog 0 234275000.0 68808000.0 55737000.0 109730000.0 False True 57216900.71124498 55436733.71807168 132674035.66580383 1.0 0.9688873921683171 2.3187910218235412 25.769938016999948 -6.901624798756094 0.950932533571979 0.9463505679540221 2.465259351834471 0.9873576488509921 0.07074000398500528 0.11021937915446675 0.17074869756527764 0.055617541084167575 0.1459244451236826 1.25422427248869e-07 6.901624798756094 1.518908783880449 up FLSHSLVELLNQISPTFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLSHSLVELLNQISPTFK 18 0 I3L2B0;A0A494C0R8;K7EIG1;O75153;I3L4B5 I3L2B0 CLUH Clustered mitochondria protein homolog 0 2241708700.0 938968700.0 826370000.0 476370000.0 False True 1215513491.9901829 780381783.062388 389675547.9689656 1.0 0.6420181990614142 0.3205851276327197 30.178918761107983 -7.499241511836324 0.2592834663258223 1.123159648667332 3.721936160180883e-14 0.999845852614751 0.003445373093405347 0.12574558017636964 0.025645600143057033 0.02580171665489261 0.06495279959222482 3.167805351653315e-08 7.499241511836324 -1.1231596486672948 down FLSHSLVELLNQISPTFKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLSHSLVELLNQISPTFKK 19 1 I3L2B0;A0A494C0R8;K7EIG1;O75153;I3L4B5 I3L2B0 CLUH Clustered mitochondria protein homolog 0 74614800.0 9990700.0 22510100.0 42114000.0 False True 15156622.318005584 18492996.782785963 33790149.440778054 1.0 1.2201265159729469 2.229398393112721 23.85344494621675 -6.941756275097483 0.6430274033091983 0.9889252040946857 2.516220507744827 0.9983848918893343 0.021511147895625336 0.08697466640098063 0.051031030130790044 0.02122927680164523 0.08621624804784195 1.1435198950608318e-07 6.941756275097483 1.5272953036501415 up FLSHSLVELLNQISPTFKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLSHSLVELLNQISPTFKK 19 1 I3L2B0;A0A494C0R8;K7EIG1;O75153;I3L4B5 I3L2B0 CLUH Clustered mitochondria protein homolog 0 55981500.0 9990700.0 17212800.0 28778000.0 False True 12933158.096139213 16254892.548732763 23540699.2872156 1.0 1.2568386180622928 1.8201818235132328 23.6245712683092 -6.958200725233367 0.46009535581074806 0.9835951715087673 2.1161381584023156 0.999697520139644 0.005957483079996433 0.08035030444486584 0.023554802860865254 0.0076520754241868735 0.046537293580762494 1.1010303101050146e-07 6.958200725233367 1.1325429868935482 FLSLDYIPQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLSLDYIPQR 10 0 Q14790;Q14790-9;Q14790-7;Q14790-3;E7ETB7;E7EQ06;E7EQ01;E7EVN1;Q14790-2;Q14790-4;A0A0A0MS31;Q14790-8;Q14790-5;Q14790-6 Q14790;Q14790-2;Q14790-5 CASP8 Caspase-8;Caspase-8 subunit p18;Caspase-8 subunit p10 0 3815000.0 1364700.0 1104500.0 1345800.0 False True 1789134.9157735985 939712.9053072786 1206549.5258251661 1.0 0.525233115190175 0.6743759317354052 20.770830752118407 -10.902300643625344 11.224285397245875 1.0320380973263292 0.5998045234627901 0.9056617878540226 0.060887299889555775 0.03128671067540875 0.00027232784552230267 0.03778487750979483 0.019651291538982187 1.2522739787230725e-11 10.902300643625344 -0.4322335738635391 FLSNGHVTIPGQQDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLSNGHVTIPGQQDK 15 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 14794300.0 4172700.0 1919500.0 8702100.0 False True 4040239.9225205015 2685966.3600602658 6422758.952595884 1.0 0.6648036778926305 1.589697412966765 21.94600953674506 -6.808661376493022 1.4202167882351415 0.8170310044714604 1.605377608457338 0.8562885835225601 0.1449353867462514 0.20863155561454577 0.8296456769134634 0.0802507335329132 0.1857460847033467 1.5535978927702328e-07 6.808661376493022 0.7883466039858775 FLSNGHVTIPGQQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLSNGHVTIPGQQDK 15 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 22925400.0 7369500.0 6994700.0 8561200.0 False True 10094203.303249171 6685651.02562028 6539220.883448622 1.0 0.6623257749790189 0.6478194154603312 23.267023712988024 FLSNGHVTIPGQQDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLSNGHVTIPGQQDK 15 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 8354600.0 4172700.0 2446200.0 1735700.0 False True 3469784.931952852 2433021.8350673164 2098626.845029946 1.0 0.7012024902932448 0.6048290848530501 21.726414812179335 -13.999999997795552 0.15827538991282725 2.466299619474105 0.5082630805251815 0.9995410103393002 0.0036042743719243617 11.998693044036223 0.12566295525354412 5.401963701023285 0.08782515717795279 1.0000000050759296e-14 13.999999997795552 -1.9580365389489236 FLSPPALQGYVAWLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLSPPALQGYVAWLR 15 0 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 0 18413900.0 4491300.0 4974700.0 8947900.0 False True 6813630.4580118 4086925.9174914956 7179343.642996106 1.0 0.5998161982333351 1.0536737627962025 22.69999227331097 -6.673883145272162 1.923340082272312 0.7454280136988268 1.0518854141412035 0.29649536573953417 0.16983766991331525 0.45225092767161423 3.228868696288165 0.07099210419618279 0.1887363405805394 2.1189311950347404e-07 6.673883145272162 0.3064574004423767 FLSQLEITFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLSQLEITFR 10 0 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 8791400.0 4778800.0 1657600.0 2355000.0 False True 4627099.609782868 2319488.324269805 1738154.8515143825 1.0 0.5012834215554417 0.375646732964097 22.141676726146756 -13.999999999999941 0.19359708967997474 3.7074850404900976 0.28870464997323836 0.9994878299349971 0.00610211909742654 12.4115156558092 0.13953222437378157 12.692515844948312 0.08399356862710161 1.000000000000135e-14 13.999999999999941 -3.4187803905168592 FLSQLEITFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLSQLEITFR 10 0 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 325858000.0 112870000.0 133260000.0 79728000.0 False True 171232041.90229836 109478711.83486785 63969725.853976235 1.0 0.6393587941755332 0.3735850203227507 27.351377451306284 -7.853626979381239 0.1947398151466251 1.2435424321481272 4.990908641121361e-09 0.9998902538355045 0.0026892675043729 0.12108004251481805 0.029223476382468614 0.06395860454540778 0.09450049173933611 1.4007899609278849e-08 7.853626979381239 -1.2435424271572186 down FLSQLEITFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLSQLEITFR 10 0 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 10092500.0 4778800.0 2752400.0 2561300.0 False True 3973783.9367355164 2737572.2748913723 3096855.987886847 1.0 0.6889081838556884 0.7793216836119504 21.922082001581032 -10.207684802296015 7.638483015459393 1.0000002358347317 0.7341149337338196 0.9201967397401409 0.036911156710348864 1.48272635493333e-07 1.533838899752674e-08 0.03573910575973106 0.011913024602369444 6.198908097196261e-11 10.207684802296015 -0.2658853021009121 FLSQLEITFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLSQLEITFR 10 0 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 269091000.0 112870000.0 79828000.0 76393000.0 False True 146112440.00032377 75385501.62554835 62490257.858373076 1.0 0.5159417064377358 0.4276860879076046 27.122503773398734 -13.999999999999998 0.23936676506611282 4.194200424830652 0.3884288574235792 0.9995239178362366 0.005489357191398485 13.601106928677945 0.15485174379712374 20.75887074752376 0.04328598441420913 1.0000000000000041e-14 13.999999999999998 -3.805771567407073 FLSQPFQVAEVFTGHMGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 FLSQPFQVAEVFTGHMGK 18 0 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 0 264144200.0 82758300.0 106034000.0 75351900.0 False True 108496932.73251715 90214140.51729476 67555208.21446376 1.0 0.8314902388964686 0.6226462491894674 26.69307901656924 -6.968234811908136 0.29734198106418414 1.0373839195075276 0.4102332458274201 0.9999651525209021 0.000911119616538345 0.07687973609181194 0.011069424523745005 0.003511296185517273 0.01878373102582148 1.0758833537595966e-07 6.968234811908136 -0.6271506736801076 FLSQPFQVAEVFTGHMGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 FLSQPFQVAEVFTGHMGK 18 0 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 0 696136400.0 271698000.0 177577600.0 246860800.0 False True 263073095.7099662 248485261.73495027 182200550.81474382 1.0 0.9445483623642807 0.692585269212086 27.970888471796858 -6.941959952529815 0.6410728637028065 1.002760439648204 0.6205337376142877 0.9984094809061533 0.005335158319654296 0.08688383415719138 0.050622947171142206 0.0052740056253641225 0.021505663743051795 1.1429837275549793e-07 6.941959952529815 -0.3822267020339163 FLSQPFQVAEVFTGHMGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLSQPFQVAEVFTGHMGK 18 0 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 0 196884000.0 35707000.0 111983000.0 49194000.0 False True 54170129.531366795 91998758.72282761 39470784.33750384 1.0 1.6983300486582082 0.7286448210290616 25.69099420479043 -6.713471847450925 1.7830106494531628 1.4277881136254464 0.7306988477791247 0.4815178064933252 0.2941176264893774 0.36812653899807285 2.2834528183672305 0.13117165547009696 0.33181963928791885 1.9343192441692618e-07 6.713471847450925 -0.6970892658463217 FLSQPFQVAEVFTGHMGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FLSQPFQVAEVFTGHMGK 18 0 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 0 563412900.0 82758300.0 159638500.0 321016100.0 False True 113356279.96896479 152585143.21607524 245198708.71410918 1.0 1.3460669603647077 2.1630800585661496 26.75628907809213 -6.956677193703256 0.47998085750367375 0.9803858439274069 2.562823266554841 0.9996264059435697 0.00942515209971585 0.08091021956824374 0.025685025888606446 0.011519198867617373 0.06739666426829465 1.1048995744241567e-07 6.956677193703256 1.5824374226274343 up FLSQPFQVAEVFTGHMGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FLSQPFQVAEVFTGHMGK 18 0 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 0 626021500.0 271698000.0 157741000.0 196582500.0 False True 225928925.26223466 156891217.9238629 237686991.85521623 1.0 0.6944273193074326 1.052043210400501 27.751293747231134 -6.680418552924214 1.900093204763736 0.8067355972070587 1.0506961463371636 0.32614519295464994 0.1294968041026501 0.43761239754632775 3.0549286360579897 0.05467534402095364 0.14414148620515088 2.0872835339072264e-07 6.680418552924214 0.2439605491301049 FLSQPFQVAEVFTGHMGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLSQPFQVAEVFTGHMGK 18 0 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 0 60988600.0 7812000.0 43052600.0 10124000.0 False True 10112787.997541681 40656684.963723 8281535.881012257 1.0 4.020324066281844 0.8189171851546198 23.269677453315126 -6.65934394134397 1.9753813571028545 2.9452453416459545 0.8323485706756019 0.23270270075407118 1.286198330943602 0.48603761845994564 3.645267111096895 0.5261928770107352 1.4255630842628941 2.1910690217197087e-07 6.65934394134397 -2.1128967709703526 FLSSAAAVSK(ub)EHPVVISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLSSAAAVSKEHPVVISK 18 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 7279700.0 1922800.0 2923400.0 2433500.0 True False 1861761.7664875078 4090728.8653296023 1796093.3465648624 1.0 2.197235403027625 0.9647278072282369 20.828237044854525 -6.652830672583995 1.9989247303524984 1.775156746345672 0.9699559580165881 0.20546883548810335 0.5106423095936673 0.5015923323500548 3.8449691889468447 0.20697477669162767 0.5655254082686128 2.2241769076975772e-07 6.652830672583995 -0.805200788329084 FLSSAAAVSK(ub)EHPVVISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLSSAAAVSKEHPVVISK 18 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 5436500.0 1922800.0 1420500.0 2093200.0 True False 1598893.394482936 1412847.4845528277 2530878.442136706 1.0 0.8836408289808005 1.582893800718442 20.6086423202888 -6.86413590740023 1.1645767032940755 0.9360241154302823 1.6195439578004185 0.9584770457850947 0.06233698427373598 0.14260650678195325 0.36518110606914655 0.041671143405873266 0.09777766256469839 1.3673008777528661e-07 6.86413590740023 0.6835198423701362 FLTAFLVQISAHSDQNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLTAFLVQISAHSDQNK 17 0 Q07960 Q07960 ARHGAP1 Rho GTPase-activating protein 1 0 48503000.0 12768000.0 16229000.0 19506000.0 False True 19369989.465832785 13332808.152244238 15650630.550216476 1.0 0.6883229428576777 0.8079834311641222 24.20731983355823 -10.112247327723384 4.639898619343368 1.0000191449417772 0.7481531870061416 0.8552031299607343 0.0488511898034505 9.675491561874758e-06 1.8512451995913062e-06 0.047303554608040005 0.015766653710299696 7.722406740866559e-11 10.112247327723384 -0.2518659579356356 FLTAFLVQISAHSDQNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLTAFLVQISAHSDQNK 17 0 Q07960 Q07960 ARHGAP1 Rho GTPase-activating protein 1 0 40506000.0 12768000.0 16131000.0 11607000.0 False True 16528427.694906835 15233295.669711392 9494645.097877245 1.0 0.9216421519879636 0.5744433332157166 23.97844615565068 -6.942532865566034 0.635572090718388 1.0037917964611829 0.4734023165089783 0.9984770853326167 0.0072167295975703 0.0866301430180314 0.049490369385495156 0.0071678550966065456 0.029565434872728575 1.1414769192140971e-07 6.942532865566034 -0.5303894799522046 FLTGPLNLNDPDAK(ub)CR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLTGPLNLNDPDAKCR 16 1 P86790;P86791 P86790 CCZ1B;CCZ1 Vacuolar fusion protein CCZ1 homolog B;Vacuolar fusion protein CCZ1 homolog 1 88106900.0 7187900.0 12927000.0 67992000.0 True False 10904569.805878708 10620075.850887995 54553351.39804779 1.0 0.9739105751024363 5.002797209720076 23.378429519823616 -6.905442430207352 0.9262283390215766 0.856575735512612 5.47570882199287 0.9890846482138589 0.19778624896698013 0.10750907523438616 0.15569208336487803 0.15836641802699084 0.42450991027012763 1.2432474289884925e-07 6.905442430207352 4.619133086480258 up FLTINIMNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLTINIMNK 9 0 Q4J6C6-4;Q4J6C6-3;Q4J6C6;Q4J6C6-2 Q4J6C6-4 PREPL Prolyl endopeptidase-like 0 12462400.0 2755400.0 4133300.0 5573700.0 False True 4180143.246722719 3395680.3213796997 4472055.751960505 1.0 0.8123358748631287 1.0698331344186944 21.99512095129432 -6.711305257963994 1.790731867816146 0.8847814145689686 1.06924708563422 0.4712277884751921 0.07906467708780159 0.37245283647043526 2.3290237800076206 0.03512670620702798 0.08909138487901735 1.94399320262075e-07 6.711305257963994 0.18446567106525136 FLTINIMNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLTINIMNK 9 0 Q4J6C6-4;Q4J6C6-3;Q4J6C6;Q4J6C6-2 Q4J6C6-4 PREPL Prolyl endopeptidase-like 0 6236820.0 806820.0 2016900.0 3413100.0 False True 1105123.1574906704 1927786.6890036052 2606996.0750009893 1.0 1.7444089158179457 2.3590095432626 20.075775725185412 -6.9733216847496315 0.16004710817732243 0.37836997520750626 3.7413564149804275 0.9999980611044499 0.0007736978199145503 0.0752388440270128 0.004940712802987849 0.028433863985709157 0.07373971035980521 1.0633550924109697e-07 6.9733216847496315 3.3629864397729214 FLTINIMNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLTINIMNK 9 0 Q4J6C6-4;Q4J6C6-3;Q4J6C6;Q4J6C6-2 Q4J6C6-4 PREPL Prolyl endopeptidase-like 0 11236800.0 2755400.0 4927700.0 3553700.0 False True 3566919.6170540657 4653469.163203564 2906963.064041211 1.0 1.3046184559232887 0.8149785742696619 21.76624727338677 -6.738455125186973 1.6921441526906484 1.181574105116068 0.8147776379046255 0.5979998766806807 0.12799418749439379 0.32065723079771413 1.8021609620176056 0.059850644476285415 0.14712971956796658 1.8261854355531058e-07 6.738455125186973 -0.36679646721144243 FLTK(ub)GDNNAVDDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLTKGDNNAVDDR 13 1 H0YNG3;P67812-2;P67812-4;P67812;P67812-3;H0YKT4;H0YNX5;P0C7V7 H0YNG3;P0C7V7 SEC11A;SEC11B Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11A;Putative signal peptidase complex catalytic subunit SEC11B 1 24268400.0 2685000.0 5694400.0 15889000.0 True False 3520061.0015769894 4844817.716597351 14244958.69805028 1.0 1.376344817441195 4.046793135592971 21.747168999865735 -6.932397984750339 0.7268370970593295 0.9627849054360823 4.630078277491086 0.996988947378284 0.07442417447464204 0.09141161363677332 0.07171902833996383 0.0687983066297479 0.238523226741321 1.168428159993048e-07 6.932397984750339 3.667293372055004 up FLTK(ub)GDNNAVDDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLTKGDNNAVDDR 13 1 H0YNG3;P67812-2;P67812-4;P67812;P67812-3;H0YKT4;H0YNX5;P0C7V7 H0YNG3;P0C7V7 SEC11A;SEC11B Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11A;Putative signal peptidase complex catalytic subunit SEC11B 1 75178600.0 4057700.0 6731500.0 64389400.0 True False 3928890.5345726856 9419423.054308759 47523884.49940561 1.0 2.3974765831273626 12.096006259582492 21.90569054179648 -6.93283886278572 0.7231091094176861 0.8669267549076171 14.239093120930931 0.9970673844623741 0.26721630318787215 0.09119030602037151 0.07065350794818587 0.2476960087583506 0.8642592804640858 1.1672426212632098e-07 6.93283886278572 13.372166366023315 FLTK(ub)GDNNAVDDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLTKGDNNAVDDR 13 1 H0YNG3;P67812-2;P67812-4;P67812;P67812-3;H0YKT4;H0YNX5;P0C7V7 H0YNG3;P0C7V7 SEC11A;SEC11B Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11A;Putative signal peptidase complex catalytic subunit SEC11B 1 250819900.0 9194900.0 69489000.0 172136000.0 True False 13949335.537232576 57088145.02996489 138113244.15011117 1.0 4.092535080082436 9.901062583337328 23.733693066554856 -6.961254539990412 0.41737825110018933 0.735890041259769 13.475880111336554 0.999813931657948 0.05033141968025955 0.07925599914282164 0.019497805954173497 0.07502211469045625 0.4838741096447493 1.0933153863170245e-07 6.961254539990412 12.739990070076786 FLTK(ub)GDNNAVDDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLTKGDNNAVDDR 13 1 H0YNG3;P67812-2;P67812-4;P67812;P67812-3;H0YKT4;H0YNX5;P0C7V7 H0YNG3;P0C7V7 SEC11A;SEC11B Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11A;Putative signal peptidase complex catalytic subunit SEC11B 1 37703100.0 2685000.0 3085700.0 31932400.0 True False 3677717.059396711 2949363.570954645 24390624.78842154 1.0 0.8019549963526709 6.632001427652662 21.810379061388627 -6.8990379623556555 0.9673534003822324 0.7511681435352044 7.232095717590667 0.986080883180132 0.31887920564956634 0.11211607418918748 0.18145094495695877 0.2476789901620646 0.6413473093587899 1.261717241105238e-07 6.8990379623556555 6.480927574055462 up FLTK(ub)GDNNAVDDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLTKGDNNAVDDR 13 1 H0YNG3;P67812-2;P67812-4;P67812;P67812-3;H0YKT4;H0YNX5;P0C7V7 H0YNG3;P0C7V7 SEC11A;SEC11B Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11A;Putative signal peptidase complex catalytic subunit SEC11B 1 47256100.0 4057700.0 8607700.0 34590700.0 True False 3374157.3365890407 8561328.611605324 41823455.44067374 1.0 2.5373234729652623 12.395229762152516 21.686095817230758 -6.934444669556881 0.7093577589517003 0.8719359576576556 14.668900879457304 0.9973419949527321 0.2602835196080163 0.09039470102898525 0.06684907101590683 0.24374668775229258 0.8712033116995659 1.1629347029978458e-07 6.934444669556881 13.796964921799649 FLTK(ub)GDNNAVDDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLTKGDNNAVDDR 13 1 H0YNG3;P67812-2;P67812-4;P67812;P67812-3;H0YKT4;H0YNX5;P0C7V7 H0YNG3;P0C7V7 SEC11A;SEC11B Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11A;Putative signal peptidase complex catalytic subunit SEC11B 1 179511700.0 9194900.0 82440000.0 87876800.0 True False 11902979.308576016 77852141.52941571 71884124.0921116 1.0 6.540559259254007 6.0391707175630875 23.504819388647306 -10.386057061678903 6.041201934403686 0.9989660695611562 6.289864988408549 0.9933072515279046 0.2046910150034954 0.0028504246077183577 0.00028967458056140306 0.1981885351365456 0.06606374101890128 4.110957039499054e-11 10.386057061678903 5.290898918847393 FLTK(ub)GDNNEVDDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLTKGDNNEVDDR 13 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 84080900.0 5408400.0 9197100.0 69475400.0 True False 7090464.775020101 7824928.530015021 62286752.06309536 1.0 1.1035847124694076 8.78457957827155 22.75744876754211 -6.9098393145426655 0.8968284353762944 0.7609706945676853 9.773814797782471 0.9908607824997229 0.34850862564603785 0.10452438673339168 0.13934436133202513 0.28510213213495794 0.7861373905823026 1.2307240445586544e-07 6.9098393145426655 9.012844103214785 up FLTK(ub)GDNNEVDDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLTKGDNNEVDDR 13 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 186237500.0 7651900.0 12420000.0 166165600.0 True False 7408994.622938292 17379370.76944435 122641844.49885273 1.0 2.345712428463332 16.553102106344205 22.820846355997308 -6.9253269679120075 0.784211693809125 0.7424928526237826 19.150512982906722 0.9955371837549737 0.4700415737937897 0.09513787163373554 0.09010987919778304 0.41687114165805295 1.320091042318064 1.1876077747996862e-07 6.9253269679120075 18.40802013028294 FLTK(ub)GDNNEVDDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLTKGDNNEVDDR 13 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 671504000.0 27596000.0 231797000.0 412111000.0 True False 41865149.53783841 190431014.3117726 330657080.2153318 1.0 4.548676319420714 7.898146402569959 25.319246442498326 -7.418270122647583 0.27588570797605594 1.961732297931524e-18 11.042472675322395 0.9998232563756281 0.03744458402681067 0.12897785422558164 0.026025985902350102 0.21757539433988576 0.6349660134858409 3.817067828608056e-08 7.418270122647583 11.042472675322395 FLTK(ub)GDNNEVDDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLTKGDNNEVDDR 13 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 117607700.0 5408400.0 7704100.0 104495200.0 True False 7408031.636514396 7363707.387948189 79815585.90619782 1.0 0.9940167306592305 10.774196145813491 22.820658829065003 -6.906756136063998 0.9175392163895909 0.6652530096736031 11.954211210096954 0.9896388524484043 0.4691499664700647 0.10660241787507943 0.15069113555842698 0.37804240811800105 1.0215428199042618 1.2394923877817434e-07 6.906756136063998 11.288958200423352 up FLTK(ub)GDNNEVDDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLTKGDNNEVDDR 13 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 164530000.0 7651900.0 25790000.0 131088100.0 True False 6362893.886646539 25651064.151085824 158498015.62710732 1.0 4.031351867256237 24.909737369617076 22.601251631431584 -6.932991305090661 0.7218194764921945 0.7150477402727392 29.54179177894278 0.9970941281818945 0.5729657722260335 0.09111414795332862 0.0702882434048253 0.5316167149004927 1.859039177321146 1.1668329777201891e-07 6.932991305090661 28.826744038670043 FLTK(ub)GDNNEVDDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLTKGDNNEVDDR 13 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 595284000.0 27596000.0 200346000.0 367342000.0 True False 35723565.998484366 189196568.9817119 300489525.2472152 1.0 5.296127743510793 8.411520990372686 25.090372764590775 -8.040396657421258 0.3145150247014819 2.6765513214296844e-18 10.196697538666374 0.9988435501814368 0.10332952764615015 0.100919450020407 0.06749748242950333 0.5817866382247066 0.8665961540785899 9.11178245964891e-09 8.040396657421258 10.196697538666374 FLTLPPVLHLQLMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLTLPPVLHLQLMR 14 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 35090010.0 16529000.0 14777000.0 3784010.0 False True 16004295.94251716 20677533.161037017 2792864.263133308 1.0 1.2919989254950537 0.1745071618998096 23.931955875766647 -6.8372724032171055 1.2949118988063424 1.1554321137739583 0.13966874374926144 0.9196885720405968 0.13410893198595236 0.17199768466875814 0.5613904525488431 0.08124307031975611 0.18706307978486436 1.4545464569161678e-07 6.8372724032171055 -1.0157633700246969 down FLTLPPVLHLQLMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 FLTLPPVLHLQLMR 14 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 2510249800.0 883104100.0 849060100.0 778085600.0 False True 1339733483.2576547 697538691.4181596 624296640.1129662 1.0 0.5206548168983923 0.4659856963453251 30.319298884053637 -13.999999999999998 0.30644993941511495 5.538560261497203 0.4534124323040608 0.9996641662010496 0.004396194086480184 17.02095956267987 0.1760128019212109 49.16160115693465 0.0192248509685184 1.0000000000000041e-14 13.999999999999998 -5.085147829193142 FLTLPPVLHLQLMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FLTLPPVLHLQLMR 14 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 182958350.0 12951000.0 35585100.0 134422250.0 False True 17739334.687615186 34012832.617810585 102674483.06313977 1.0 1.9173679969833834 5.787955685554685 24.08044856669846 -6.9436503498160365 0.6246802694137347 0.9577409364236038 6.954292638112837 0.9986040044025 0.07752518216291161 0.08614006564456222 0.04731736805177886 0.07774373839743437 0.328156647725936 1.1385435575518235e-07 6.9436503498160365 5.996551701689233 FLTLPPVLHLQLMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FLTLPPVLHLQLMR 14 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 638487460.0 192329000.0 266665100.0 179493360.0 False True 159930085.11936158 265228522.17742217 217024591.69247207 1.0 1.6584029326281704 1.3569966622008536 27.252866114864172 -9.9878828841799 4.349029597261071 0.9999808005447111 1.5076997972550712 0.7909306914769285 0.12304859510723241 7963434.180467745 4573778.360414346 1390.8354691703619 0.042122807437962255 1.02829355978183e-10 9.9878828841799 0.5077189967103601 FLTLPPVLHLQLMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FLTLPPVLHLQLMR 14 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 2198336100.0 883104100.0 747361100.0 567870900.0 False True 1143195666.0342865 705769797.8017933 464524223.04748297 1.0 0.6173657045517753 0.40633833459052937 30.090425206146087 -10.106296928161782 0.12675929736408306 1.7699128997807247 8.105005254460832e-11 0.9998384196663798 0.003123362352126835 1.7306887982317247 0.06060018441945306 0.661200278824536 0.23081452238617614 7.828941931362792e-11 10.106296928161782 -1.7699128996996747 FLTPLK(ub)NLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLTPLKNLVK 10 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 4091110.0 991210.0 1646100.0 1453800.0 True False 1299485.9088912935 1400508.2964475458 1303374.7218343175 1.0 1.0777402716451487 1.0029925780005895 20.30950955920749 -6.6369939602465085 2.0551623873152236 1.0509529061445526 1.003300494371471 0.1432185476395771 0.0332878002154474 0.5410072013622819 4.363372075285842 0.013206670608076426 0.03686487143318466 2.3067792689832224e-07 6.6369939602465085 -0.04765241177308166 FLTPLK(ub)NLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLTPLKNLVK 10 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 5167400.0 2223700.0 2943700.0 0.0 True False 2153109.860691841 4119134.761192708 0.0 1.0 1.9131094220473914 0.0 21.037990503056765 -6.784385481849856 1.5678145772191185 1.5186873832068568 3.996755459328519e-18 0.756019911360073 0.38591409407984784 0.2502968481222032 1.2232163587531828 0.1953381845065617 0.4500269248983939 1.6429128186055105e-07 6.784385481849856 -1.5186873832068568 FLTPLK(ub)NLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLTPLKNLVK 10 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 12728500.0 4232600.0 3990800.0 4505100.0 True False 6421163.644508438 3278610.559737286 3614665.010344526 1.0 0.5105944562776011 0.5629299003204645 22.614403335836503 -10.840117775916275 11.103865752567344 1.0077712925506115 0.5367621782990328 0.9905178373416096 0.02136585556116614 0.004020708540692786 5.789323841358013e-05 0.02023571621383057 0.006895800230489129 1.4450478364265727e-11 10.840117775916275 -0.47100911425157865 FLTPLK(ub)NLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLTPLKNLVK 10 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 6479910.0 991210.0 3833100.0 1655600.0 True False 1357687.1234430573 3663740.9676333647 1264581.3781523085 1.0 2.698516399229167 0.9314232685254942 20.372719620730383 -6.655171675891733 1.989843989112457 2.0976480410214693 0.9388183854661682 0.21526287234157426 0.7240364050493264 0.4960640611736896 3.7704415316778217 0.29448791162156857 0.8023574964281827 2.212220049807637e-07 6.655171675891733 -1.158829655555301 FLTPLK(ub)NLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLTPLKNLVK 10 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 8386300.0 2223700.0 3763500.0 2399100.0 True False 1849105.0766131189 3743225.278503743 2900740.717814914 1.0 2.024344276508048 1.5687268152051181 20.81839577849104 -10.15421074137283 5.770858894891593 0.9999895258899538 1.796535545856612 0.8029632155557349 0.18600504968252685 2.507538007143317e-05 3.6753054037607986e-06 0.180100981087459 0.06003287164422491 7.011149998476142e-11 10.15421074137283 0.7965460199666581 FLTPLK(ub)NLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLTPLKNLVK 10 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 10184400.0 4232600.0 2357600.0 3594200.0 True False 5479184.137019312 2226397.487503042 2940092.4796063066 1.0 0.4063374093344866 0.5365931142452393 22.385529657928952 -9.90363298006037 6.859806759498502 1.0000000159297016 0.47146526179036885 0.9564325587873952 0.053176668852999036 1.2976189666752298e-08 2.0691251347744756e-09 0.05148809013668206 0.017162696072868213 1.2484381169238994e-10 9.90363298006037 -0.5285347541393327 FLTVMMK ddPTM_RPMI8226_Bortezomib_1h_R1 3 FLTVMMK 7 0 P62244;I3L3P7;I3L246;H3BV27;H3BT37;I3L303;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 79647700.0 25633900.0 34386100.0 19627700.0 False True 33606291.139040746 29255827.915968016 17596813.886193037 1.0 0.8705461663391127 0.5236166589579607 25.00222799678418 -6.953955954891524 0.513585941719305 1.0062013139839456 0.37264795505395254 0.9994762540441493 0.004602829721908556 0.08193514102567445 0.029681750303826516 0.005269324740194573 0.02864032512985242 1.1118444821741214e-07 6.953955954891524 -0.6335533589299931 FLTVMMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 FLTVMMK 7 0 P62244;I3L3P7;I3L246;H3BV27;H3BT37;I3L303;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 38173300.0 15405300.0 6646400.0 16121600.0 False True 14916267.183934886 9300342.180518132 11898869.322366988 1.0 0.6235033246477901 0.7977109269792583 23.83038320858413 -10.229853761046556 5.947320589512831 1.0000076064348158 0.7106071258135224 0.7862986224378623 0.07111995583763683 7.173123459785839e-06 9.288881676637947e-07 0.06886341099720576 0.02295386704518025 5.890419686734931e-11 10.229853761046556 -0.2894004806212934 FLTVMMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLTVMMK 7 0 P62244;I3L3P7;I3L246;H3BV27;H3BT37;I3L303;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 95327000.0 34585000.0 33776000.0 26966000.0 False True 52467973.502179414 27748408.906907503 21636158.28038231 1.0 0.5288637440086168 0.4123688573465409 25.644933733307646 -13.999999999999988 0.1962411076392411 3.5824247224751167 0.33384671593226023 0.9994871692088371 0.005753046250187276 12.459095939282127 0.14047768259499563 12.33097404509357 0.07631208430072149 1.0000000000000286e-14 13.999999999999988 -3.2485780065428562 FLTVMMK ddPTM_RPMI8226_Carfilzomib_1h_R1 3 FLTVMMK 7 0 P62244;I3L3P7;I3L246;H3BV27;H3BT37;I3L303;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 77712500.0 25633900.0 23445100.0 28633500.0 False True 35111445.560100324 22409217.959422093 21870857.025443405 1.0 0.6382311409270859 0.6228982224046292 25.06543805830707 FLTVMMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FLTVMMK 7 0 P62244;I3L3P7;I3L246;H3BV27;H3BT37;I3L303;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 34338800.0 15405300.0 11481300.0 7452200.0 False True 12810189.520505495 11419447.958040392 9010420.564920304 1.0 0.8914347394908624 0.703379177216478 23.610788484018407 -6.962755755597464 0.39467955206901334 1.0109642389427587 0.5770417028814167 0.9998591463594785 0.0014542653027254135 0.07873100795724272 0.017598626337300787 0.002422807069923223 0.015788400712393715 1.0895426728012282e-07 6.962755755597464 -0.433922536061342 FLTVMMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLTVMMK 7 0 P62244;I3L3P7;I3L246;H3BV27;H3BT37;I3L303;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 111668000.0 34585000.0 41054000.0 36029000.0 False True 44770964.27227074 38769308.81063364 29472091.688758425 1.0 0.8659475944020648 0.6582858369885994 25.416060055400095 -6.964716300268489 0.3628882702566945 1.0173140448450038 0.4997709991477704 0.9999071758669207 0.0013543997457196987 0.07805736848050174 0.015200195547033946 0.002770416045319649 0.01770677252270328 1.0846352127642126e-07 6.964716300268489 -0.5175430456972334 FLTWILNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLTWILNR 8 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 55640000.0 18251000.0 23435000.0 13954000.0 False True 23927237.742935415 19938589.34891455 12510173.936219621 1.0 0.8333009252102856 0.5228423803292248 24.512150520152403 -6.9614152090041275 0.41501456137752446 1.0144820364021054 0.3300453412392135 0.9998191220106202 0.0026591993333942104 0.07919950139604146 0.01929223416996729 0.004005080963911629 0.025880450333817324 1.0929109846432617e-07 6.9614152090041275 -0.684436695162892 FLTWILNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLTWILNR 8 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 60237000.0 25890000.0 17463000.0 16884000.0 False True 25068136.12146953 24436066.968341947 12461573.89085726 1.0 0.974785953368657 0.49710811487833684 24.579351396391466 -6.917824868649303 0.840699665747777 1.0113884745187545 0.42380417737021153 0.9935550760128121 0.018572972173259695 0.09946871662317773 0.11237036201436391 0.01582085125842262 0.046448960730499096 1.2083009900957038e-07 6.917824868649303 -0.587584297148543 down FLTWILNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLTWILNR 8 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 99172000.0 32986000.0 33355000.0 32831000.0 False True 50042173.5996209 27402539.64619548 26341938.45966153 1.0 0.5475889170090539 0.5263947699478243 25.576641119048798 FLTWILNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLTWILNR 8 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 91488000.0 18251000.0 31687000.0 41550000.0 False True 24998887.914729733 30286963.565103553 31736745.74911111 1.0 1.21153243569919 1.2695263028245078 24.575360581675294 -13.727066030002984 0.1846206602926337 8.477601250395182e-16 1.3139706991550462 0.9994853034196021 0.002627867965194536 11.03447548581743 0.1345306623121129 3.979696894754895 0.04167264111887449 1.874709456134013e-14 13.727066030002984 1.3139706991550453 FLTWILNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLTWILNR 8 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 62501000.0 25890000.0 24486000.0 12125000.0 False True 21528682.121470373 24354089.05790957 14660281.4403342 1.0 1.131239196180125 0.6809651123843584 24.359756671825743 -6.828696876344336 1.3336407551706242 1.0701936108806744 0.6691614733804093 0.9032513516823872 0.05881160018114273 0.18243058446140892 0.6350253987940041 0.034628081815705695 0.0796975381983598 1.483553196540215e-07 6.828696876344336 -0.4010321375002651 FLTWILNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLTWILNR 8 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 152151000.0 32986000.0 60229000.0 58936000.0 False True 42701027.25126851 56877203.2044539 48210252.73442695 1.0 1.3319867662613258 1.1290185702264288 25.347767441141247 -10.217275356742404 4.1263888712189 0.9998683419417611 1.2305026681243267 0.6323027363745294 0.08286141915074573 58348440.42254074 18.411254354804477 75276.10665981434 0.028365667744616678 6.063517610668913e-11 10.217275356742404 0.23063432618256563 FLVEDYCFADLAPQK(ub)PAPPLDTDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLVEDYCFADLAPQKPAPPLDTDR 24 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9JHC7 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 95379700.0 5124700.0 26331000.0 63924000.0 True False 7774544.565754486 21632027.324958015 51289393.381115474 1.0 2.7824173032904493 6.597092980473263 22.89032673370282 -6.958698581671268 0.45340245726467804 0.881173786883126 8.650424015892211 0.9997188456105198 0.03914697232246834 0.08016931990655757 0.022874045708257032 0.05125248375211286 0.31538443002200367 1.0997688596826958e-07 6.958698581671268 7.769250229009085 FLVEDYCFADLAPQK(ub)PAPPLDTDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLVEDYCFADLAPQKPAPPLDTDR 24 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9JHC7 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 100721700.0 5124700.0 16098000.0 79499000.0 True False 6634025.172939307 15202132.148720711 65030997.728624314 1.0 2.2915397141891116 9.802645608565173 22.66145305579527 -6.936499355464419 0.6913656995437206 0.9084468424965749 11.635269773810816 0.9976684460839379 0.18740684393629292 0.08940069226535001 0.06215865319486652 0.17790720231345392 0.6570533224339498 1.1574457498539081e-07 6.936499355464419 10.72682293131424 FLVEEK(ub)IK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLVEEKIK 8 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 7554800.0 1539000.0 2378600.0 3637200.0 True False 1490145.2874060099 3328387.384235134 2684508.2063389 1.0 2.233599241875984 1.801507697958763 20.507021567932203 -10.132408300402073 4.837263243767853 0.9999353173513373 2.0175534699232083 0.8808726586742583 0.1764006341482103 61592043.50674735 5.733844497452995 44373.94821399086 0.06038662904770791 7.372108181148614e-11 10.132408300402073 1.0176181525718708 FLVEEK(ub)IK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLVEEKIK 8 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 23668800.0 5930300.0 10572000.0 7166500.0 True False 8996698.663003461 8685344.00058699 5750038.133811469 1.0 0.9653923428938623 0.6391275676995803 23.10096427118151 -6.92717623681428 0.7696186075307391 1.005515624223166 0.5767222180498315 0.9959535296521288 0.010341690560577217 0.09413089227041477 0.0850595987298327 0.0092680788405444 0.029992793671438915 1.1825615745474362e-07 6.92717623681428 -0.4287934061733345 FLVEEK(ub)IK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLVEEKIK 8 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 6063400.0 1539000.0 2944800.0 1579600.0 True False 1279746.6892600579 2928935.7779029636 1909887.056754799 1.0 2.288684004798213 1.4923946065131724 20.28742684336648 -10.11246965977023 5.325114329241743 0.999983271673198 1.8905393056562774 0.6251372302655549 0.32508378556641443 6.456347123908969e-05 1.0761008834296827e-05 0.31476691819456143 0.1049203406347697 7.718454355652463e-11 10.11246965977023 0.8905560339830794 FLVEEK(ub)IK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLVEEKIK 8 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 21569900.0 5930300.0 11228000.0 4411600.0 True False 7676890.253689382 10603151.92979477 3608734.066838568 1.0 1.3811780003887741 0.47007758969906754 22.87209059327396 -6.793104959110752 1.4843165282014719 1.2121844255280076 0.4595974378571868 0.8111027488149012 0.16237685932619594 0.2307565909987101 1.0043289545697502 0.08609948271109517 0.20109765364993465 1.6102564257494426e-07 6.793104959110752 -0.7525869876708209 down FLVEYK(ub)SAVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLVEYKSAVEK 11 1 O14929;F8W9G7;F8WEW1 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 123071000.0 37128000.0 44223000.0 41720000.0 True False 48675167.54806344 37625100.779903874 37403214.60649863 1.0 0.7729834877866959 0.7684249791141546 25.53668260916315 FLVEYK(ub)SAVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLVEYKSAVEK 11 1 O14929;F8W9G7;F8WEW1 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 209886000.0 66480000.0 88032000.0 55374000.0 True False 64369628.789312184 123183636.68081544 40869888.21560823 1.0 1.9136918916218548 0.634925025735028 25.939876813261698 -6.714848852736507 1.7776127170039964 1.55889930574561 0.6374356093360845 0.48825185860024556 0.3847456971212135 0.36540287631249674 2.2535556108155594 0.17204032089424123 0.43456304843012644 1.928195865347676e-07 6.714848852736507 -0.9214636964095255 FLVEYK(ub)SAVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLVEYKSAVEK 11 1 O14929;F8W9G7;F8WEW1 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 269731000.0 128409000.0 105222000.0 36100000.0 True False 194805840.95536637 86444311.9967617 28964819.176807914 1.0 0.44374599638707796 0.1486855785984584 27.537461694173203 -8.792223099337274 0.2889892727789477 1.229200997945436 6.016979577379089e-17 0.9987904305682468 0.012275484093815243 0.324762118993259 0.09136406193855705 0.17794925766540728 0.09971487140546614 1.6135294654003623e-09 8.792223099337274 -1.229200997945436 FLVEYK(ub)SAVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLVEYKSAVEK 11 1 O14929;F8W9G7;F8WEW1 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 133836000.0 37128000.0 53053000.0 43655000.0 True False 50855224.94647336 50708943.03718987 33344588.10294694 1.0 0.9971235618476282 0.6556767399621791 25.599892670686042 -6.90874554327352 0.9042368360173362 1.0109958641187526 0.6127145607661594 0.9904394572874538 0.01580501771245401 0.10525336661662776 0.1433108656577452 0.012860050844821027 0.035198388853129876 1.233827531239256e-07 6.90874554327352 -0.39828130335259326 FLVEYK(ub)SAVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLVEYKSAVEK 11 1 O14929;F8W9G7;F8WEW1 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 325217000.0 128409000.0 137048000.0 59760000.0 True False 166227981.8198064 129421158.32512589 48884293.18938091 1.0 0.7785762475623409 0.2940798092728588 27.308588016265652 -6.958249567632527 0.4594398374346205 1.0142014788118063 0.038941966638958145 0.999699664063808 0.0051086963950828 0.08033245139920427 0.023487349345828575 0.006573767471619794 0.040026741106722545 1.1009064910369236e-07 6.958249567632527 -0.9752595121728482 down FLVGFTNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLVGFTNK 8 0 C9J3L8;C9J5W0;A0A3B3IRT8;E9PAL7;C9IZQ1;P43307;P43307-2 C9J3L8 SSR1 Translocon-associated protein subunit alpha 0 55207000.0 20533000.0 16718000.0 17956000.0 False True 26918961.841854885 14223739.566253584 16098085.366114337 1.0 0.5283910891443754 0.5980202899609697 24.682119436177288 -10.60786326040698 6.495955789391571 1.0012387225650523 0.5632056895527227 0.9812978724719154 0.028426002199739633 0.000511228662005818 3.08609398538864e-05 0.027591918225171142 0.00917445275990391 2.4668159031827193e-11 10.60786326040698 -0.43803303301232965 FLVGFTNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLVGFTNK 8 0 C9J3L8;C9J5W0;A0A3B3IRT8;E9PAL7;C9IZQ1;P43307;P43307-2 C9J3L8 SSR1 Translocon-associated protein subunit alpha 0 17464400.0 8167800.0 2454700.0 6841900.0 False True 7908517.659827689 3434874.5110913906 5049801.137399687 1.0 0.4343259582689267 0.6385268838749375 22.91497587650961 -10.116018325244832 5.140658019612431 1.0000132394879955 0.536426421071215 0.8729617399885666 0.08336467879230036 1.2649911698793504e-05 2.1751540553108846e-06 0.08071980568812522 0.026905834385015485 7.655643029104974e-11 10.116018325244832 -0.4635868184167805 FLVGFTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLVGFTNK 8 0 C9J3L8;C9J5W0;A0A3B3IRT8;E9PAL7;C9IZQ1;P43307;P43307-2 C9J3L8 SSR1 Translocon-associated protein subunit alpha 0 41455000.0 20533000.0 10676000.0 10246000.0 False True 28124604.983460974 10204299.019189095 7826105.8229938 1.0 0.36282461656580994 0.27826544862038205 24.74532949770018 -13.999999999999998 0.28464665908416054 6.3283086084798725 0.2539541551445087 0.9996155013402154 0.006316980363353064 15.655213073681763 0.16908453481213057 48.69326727792057 0.032727799104417 1.0000000000000041e-14 13.999999999999998 -6.0743544533353635 FLVGFTNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLVGFTNK 8 0 C9J3L8;C9J5W0;A0A3B3IRT8;E9PAL7;C9IZQ1;P43307;P43307-2 C9J3L8 SSR1 Translocon-associated protein subunit alpha 0 14560000.0 8167800.0 3836100.0 2556100.0 False True 6791887.594891686 3815434.1678937715 3090568.691928932 1.0 0.5617634441953125 0.4550382568541638 22.695381151943888 -13.999999999999998 0.19839444377182794 3.4213737892306204 0.3846191823953911 0.9994869332517159 0.005341151026860444 12.499614505740126 0.14123994848131888 11.736904145512018 0.06877970326824127 1.0000000000000041e-14 13.999999999999998 -3.0367546068352294 FLVQNIHTLAELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLVQNIHTLAELK 13 0 Q8TDN6 Q8TDN6 BRIX1 Ribosome biogenesis protein BRX1 homolog 0 6325700.0 1008500.0 2329200.0 2988000.0 False True 1381369.7036877386 2226288.2423656117 2282295.9397916747 1.0 1.6116527215142027 1.6521977669691186 20.39766805712881 -11.41047325170578 0.4522623046341069 3.519724167423605e-13 1.6523206966978563 0.9997665873375079 0.004558172041342274 3.807684274921908 0.22323836516910364 3.768247529327494 0.009096710600607507 3.8862143249821715e-12 11.41047325170578 1.6523206966975044 FLVTVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLVTVIK 7 0 O14980 O14980 XPO1 Exportin-1 0 14308100.0 4075300.0 4642700.0 5590100.0 False True 5342757.765261334 3950027.2571028573 5011690.076025599 1.0 0.7393236659138798 0.938034306666804 22.349153177767214 -9.815029330717401 5.2945412400903145 1.0000000858646882 0.8386789865970236 0.4677386755411984 0.08112327940053601 109751100.83368124 50.724705310108995 114.88730539343986 0.027770656289061904 1.5309840609272433e-10 9.815029330717401 -0.1613210992676647 FLVTVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLVTVIK 7 0 O14980 O14980 XPO1 Exportin-1 0 5693700.0 2499400.0 1072100.0 2122200.0 False True 2420057.9151023915 1500195.120927641 1566332.1553646785 1.0 0.6199005038539205 0.6472292029004635 21.206610142787362 -10.756138109858254 6.929846048890778 1.0074829308927435 0.6335648533774417 0.9958457071638679 0.011156894666352588 0.0012976992056271566 4.566609147071722e-05 0.010868321271541779 0.0036008722698478205 1.7533228395038282e-11 10.756138109858254 -0.3739180775153018 FLVTVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLVTVIK 7 0 O14980 O14980 XPO1 Exportin-1 0 12108000.0 4075300.0 2828900.0 5203800.0 False True 5582048.540841487 2703909.8440786833 3974769.6156251356 1.0 0.4843938250080269 0.7120628899128032 22.412363239290105 -10.323851074088951 5.792965471643705 1.0000486487738856 0.5982283574604145 0.8059121119390336 0.09294550653888686 5.840581322600061e-05 6.816959986579659e-06 0.09000495793778113 0.029998033244159304 4.74404637639081e-11 10.323851074088951 -0.4018202913134711 FLVTVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLVTVIK 7 0 O14980 O14980 XPO1 Exportin-1 0 6013000.0 2499400.0 1559600.0 1954000.0 False True 2078361.8421940145 1551198.125243636 2362572.365724789 1.0 0.7463561415302544 1.1367473737059899 20.987015418221638 -6.731348661362761 1.718164407145266 0.8475839521341358 1.13657733184345 0.5654850740573947 0.10661579658283166 0.3337599415872737 1.9308512288271258 0.049159724888890206 0.12180761179058788 1.8563135664950576e-07 6.731348661362761 0.28899337970931416 FLVTVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLVTVIK 7 0 O14980 O14980 XPO1 Exportin-1 0 8502200.0 2315900.0 3353000.0 2833300.0 False True 2997978.2032138705 3166402.602476116 2317668.472112999 1.0 1.0561793274819984 0.7730771590095048 21.51555846354071 -6.855134301134788 1.209973758375506 1.0301695146153877 0.7605823132167371 0.947456589296682 0.0280529067437616 0.15190132663204506 0.42536765581450564 0.018114543399203133 0.04208199158137049 1.3959366151558434e-07 6.855134301134788 -0.26958720139865067 FLVYVANFDEKDPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLVYVANFDEKDPR 14 1 P50395;P50395-2;Q5SX87;Q5SX86 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 46079900.0 17131900.0 18115900.0 10832100.0 False True 22460086.805555582 15413078.335225116 9711298.200840218 1.0 0.6862430438787368 0.4323802612569642 24.420860167805017 -7.373718425092126 0.18497508153371658 1.213249976028424 3.86084694250542e-16 0.9999784783497331 0.0010770052705601737 0.11743026190248758 0.01325616786269013 0.025112245064002624 0.05407817001403641 4.2294274039529905e-08 7.373718425092126 -1.2132499760284237 down FLVYVANFDEKDPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLVYVANFDEKDPR 14 1 P50395;P50395-2;Q5SX87;Q5SX86 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 38556700.0 14215600.0 8651900.0 15689200.0 False True 13764333.559226045 12106648.789062459 11579727.85408893 1.0 0.8795666522443099 0.8412850360144896 23.714431423503857 -13.999999999997968 0.16038608717562475 1.5936038846558198 0.8038121739241444 0.9995353501561917 0.001457728076390745 12.012350118343027 0.1265720722242615 2.218144721194662 0.03416997670816261 1.0000000000046792e-14 13.999999999997968 -0.7897917107316754 FLVYVANFDEKDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLVYVANFDEKDPR 14 1 P50395;P50395-2;Q5SX87;Q5SX86 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 124615900.0 34159300.0 49620600.0 40836000.0 False True 51822155.47934065 40765416.24248261 32764746.70094539 1.0 0.7866406919089673 0.6322536451423241 25.62706568811786 -6.9746403131125785 0.09626628245240677 1.4060793136926883 0.008907614867296383 0.9999997813876452 7.025902931597527e-05 0.07482365801167122 0.0028190111077134104 0.014648855298063418 0.026023843198610466 1.0601313727382265e-07 6.9746403131125785 -1.397171698825392 FLVYVANFDEKDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLVYVANFDEKDPR 14 1 P50395;P50395-2;Q5SX87;Q5SX86 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 68874500.0 17131900.0 20789700.0 30952900.0 False True 23466026.402189355 19871142.311655633 23642462.514985856 1.0 0.8468047368173793 1.0075187894947581 24.48407022932791 -11.137341452216221 9.833583324245183 2.632743782943698 0.9271617631560686 0.2149926449769406 0.06561123725905912 0.042197430984590764 0.000589354459612935 0.0011414088460916817 0.021175935769033295 7.288842195373897e-12 11.137341452216221 -1.7055820197876295 FLVYVANFDEKDPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLVYVANFDEKDPR 14 1 P50395;P50395-2;Q5SX87;Q5SX86 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 32989500.0 14215600.0 8062900.0 10711000.0 False True 11820901.257859185 8019463.557339655 12950620.577931527 1.0 0.6784138859131299 1.0955696435854452 23.494836698938133 -6.700817883060806 1.8278263711139937 0.8004657897166146 1.0943518331059157 0.4214557405489733 0.1357258236839974 0.3938567246414919 2.5587483020320043 0.05922476073333418 0.15216401972427585 1.9915082824965022e-07 6.700817883060806 0.293886043389301 FLVYVANFDEKDPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLVYVANFDEKDPR 14 1 P50395;P50395-2;Q5SX87;Q5SX86 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 125111600.0 34159300.0 51827900.0 39124400.0 False True 44219887.2304692 48943631.80461438 32004160.650244556 1.0 1.1068239850890063 0.7237503904847695 25.39819201021031 -6.832281224686965 1.3175758675329696 1.0569981569384692 0.7129458952023146 0.9103710693588307 0.04832223771993849 0.1780205026321292 0.6035829161536718 0.028787701279676888 0.06625169271011314 1.4713594242545713e-07 6.832281224686965 -0.34405226173615466 FLYIWPNAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLYIWPNAR 9 0 Q9HCC0-2;Q9HCC0;D6RD67 Q9HCC0-2 MCCC2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial 0 7095800.0 2327400.0 2273700.0 2494700.0 False True 3051243.938573663 1934472.8228131833 2236572.3748521637 1.0 0.6339948105615815 0.7330034634653543 21.540966093358165 -10.09657351000664 7.314354577694774 1.00000007805365 0.683499137013469 0.9316247692338302 0.04042011328909528 5.14644328921116e-08 6.298752996922624e-09 0.03913661631912895 0.01304553546837359 8.006201016405058e-11 10.09657351000664 -0.316500941040181 FLYIWPNAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLYIWPNAR 9 0 Q9HCC0-2;Q9HCC0;D6RD67 Q9HCC0-2 MCCC2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial 0 12946900.0 2024400.0 5421800.0 5500700.0 False True 2620625.706889831 5120072.063854758 4499629.041948255 1.0 1.9537593828808462 1.7170056105755114 21.321479883549692 -9.98941625174297 5.138307234883282 0.9999946421774185 1.8353824967340484 0.9431827528642911 0.0966543228249683 5.935330207526153e-06 1.1675700237892238e-06 0.09358574491102209 0.03119504855040078 1.0246693559246103e-10 9.98941625174297 0.8353878545566299 FLYNLTLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FLYNLTLQR 9 0 Q15393;Q15393-2;I3L4G7;H3BMB0 Q15393 SF3B3 Splicing factor 3B subunit 3 0 14430200.0 3950100.0 5858700.0 4621400.0 False True 5178619.352822816 4984604.797033738 4143221.859599062 1.0 0.9625354669708786 0.8000630240067038 22.304136088407553 -6.943022455368084 0.6308194709491718 1.0017723785172266 0.7520574360859753 0.9985335743370318 0.003323112620501654 0.08641446321383099 0.04853100291076499 0.0033143432599440155 0.013808312895962009 1.1401908320187567e-07 6.943022455368084 -0.24971494243125125 FLYNLTLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FLYNLTLQR 9 0 Q15393;Q15393-2;I3L4G7;H3BMB0 Q15393 SF3B3 Splicing factor 3B subunit 3 0 16534100.0 8329800.0 3128500.0 5075800.0 False True 8065375.058501989 4377726.364911976 3746295.709263992 1.0 0.542780259214017 0.4644911962667989 22.94331019290467 -13.999999999999998 0.24827827983457756 4.152365927834899 0.4324928048194281 0.9995394827632551 0.005067935700487385 13.930394509976576 0.1576746585261744 21.878551827096448 0.03647907658544441 1.0000000000000041e-14 13.999999999999998 -3.7198731230154714 FLYNLTLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FLYNLTLQR 9 0 Q15393;Q15393-2;I3L4G7;H3BMB0 Q15393 SF3B3 Splicing factor 3B subunit 3 0 20913700.0 3950100.0 8140300.0 8823300.0 False True 5410558.717438713 7780634.629627667 6739418.261567568 1.0 1.4380464266194892 1.2456048651400498 22.367346149930444 -10.152458795119996 4.4392740749623485 0.9999409344911835 1.3418256458912343 0.8079428905880791 0.07856393852703276 4.5935610010294115e-05 8.769833597583913e-06 0.07608232204272587 0.02535640212186339 7.039490138613973e-11 10.152458795119996 0.34188471140005083 FLYNLTLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FLYNLTLQR 9 0 Q15393;Q15393-2;I3L4G7;H3BMB0 Q15393 SF3B3 Splicing factor 3B subunit 3 0 15540900.0 8329800.0 2934100.0 4277000.0 False True 6926597.772708519 2918293.4209267474 5171300.925386344 1.0 0.4213170039157048 0.7465860000939829 22.723715468338945 -10.199959409051198 5.633020112310072 1.0000129568436746 0.5839515020048465 0.6856759542993973 0.13279051163074762 2.160836708058621e-05 3.069089050477415e-06 0.1285778606256785 0.042857953340010635 6.310163191050909e-11 10.199959409051198 -0.41606145483882817 FLYNLTLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLYNLTLQR 9 0 Q15393;Q15393-2;I3L4G7;H3BMB0 Q15393 SF3B3 Splicing factor 3B subunit 3 0 16609700.0 5365100.0 8145800.0 3098800.0 False True 6945227.711931755 7692479.069266321 2534850.1963730496 1.0 1.1075920600919684 0.3649772623031827 22.7275905656891 -6.870117126852955 1.1334231264118226 1.0608985749867108 0.321379270019685 0.964802661430106 0.06147395349079859 0.1367453589536728 0.32824902700379693 0.04208817611225145 0.09966976928778377 1.3485991237140937e-07 6.870117126852955 -0.7395193049670258 down FLYVGGALHALPTGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FLYVGGALHALPTGLR 16 0 A0A494C0M9;A0A494C134;D3DVG2;A0A1W2PRF9;A0A494C146;P50336 A0A494C0M9 PPOX Protoporphyrinogen oxidase 0 19431200.0 5948800.0 6099400.0 7383000.0 False True 9024764.51553461 5010914.41517029 5923746.813916139 1.0 0.555240461570476 0.6563879648847799 23.105457857368002 -9.753151326852974 6.0155580766235 1.000000012451176 0.6058142132263563 0.952941722441572 0.04129329531732801 6.9026968572001994e-09 1.3865560593354268e-09 0.03998206245805535 0.013327353755499425 1.765422564444898e-10 9.753151326852974 -0.3941857992248198 FLYVGGALHALPTGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FLYVGGALHALPTGLR 16 0 A0A494C0M9;A0A494C134;D3DVG2;A0A1W2PRF9;A0A494C146;P50336 A0A494C0M9 PPOX Protoporphyrinogen oxidase 0 21438500.0 5948800.0 8712300.0 6777400.0 False True 7700838.868378887 8227452.846272802 5543982.741996491 1.0 1.0683839756804019 0.7199193278489623 22.87658417946045 -6.855766064686728 1.206961651390417 1.0367603282341524 0.7043614457068166 0.9482786854323485 0.034285648534874896 0.15122989085093524 0.4210594140023428 0.022190734165749883 0.05157666153074392 1.3939074373161714e-07 6.855766064686728 -0.33239888252733585 FMCGEK(ub)QFSEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FMCGEKQFSEER 12 1 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 1 4336700.0 1672200.0 0.0 2664500.0 True False 1390508.3910205755 0.0 3221634.630743956 1.0 0.0 2.3168753612334623 20.40718101997587 -6.78940224908785 1.498711004488626 0.44066904018849445 2.341120698903894 0.7993986653010878 0.42495574778556156 0.2362345899122871 1.04825842345612 0.2231929056423167 0.522779809579814 1.624043848801299e-07 6.78940224908785 1.9004516587153995 FMEDTAAEK(ub)LHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FMEDTAAEKLHK 12 1 Q03154;A0A1B0GV31;A0A1B0GU86;A0A1B0GW23;Q03154-4;C9JMV9;Q03154-2;A0A1B0GVA5 Q03154 ACY1;ABHD14A-ACY1 Aminoacylase-1 1 9811000.0 1824900.0 1942500.0 6043600.0 True False 2392461.5723567363 1652686.5718056953 5418266.24630477 1.0 0.6907891816952727 2.264724461579298 21.190064321698756 -6.855705417780258 1.2072593174478445 0.8337996491708004 2.334914779513261 0.9481993483283144 0.1549672501320226 0.15129414390314605 0.4214785735687915 0.10027678643659639 0.23305528909080447 1.3941021026418648e-07 6.855705417780258 1.5011151303424606 up FMELNLAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FMELNLAQK 9 0 P61758;P61758-2 P61758 VBP1 Prefoldin subunit 3 0 15428100.0 4407000.0 5772100.0 5249000.0 False True 5777619.677448703 4910925.179469579 4705883.831963363 1.0 0.8499910782701707 0.8145021816391694 22.462043808270394 -13.999999999999547 0.20249636866843432 1.8419157419521055 0.7920128005907525 0.9994872023419202 0.0018205600368952856 12.581302834529863 0.1426743086376676 4.199791757609884 0.022183851081554802 1.000000000001043e-14 13.999999999999547 -1.049902941361353 FMELNLAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FMELNLAQK 9 0 P61758;P61758-2 P61758 VBP1 Prefoldin subunit 3 0 9349800.0 3080100.0 1266400.0 5003300.0 False True 2982323.9114614977 1772080.1241887559 3692785.6342173754 1.0 0.5941943855858173 1.2382241982587712 21.50800552717395 -6.73647175604563 1.7004096824232648 0.7575533908712436 1.238259773009593 0.5886577042890854 0.17052121161501396 0.32423688713225 1.8395080544167632 0.07939232447894339 0.19552141860354222 1.834544471202088e-07 6.73647175604563 0.4807063821383494 FMELNLAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FMELNLAQK 9 0 P61758;P61758-2 P61758 VBP1 Prefoldin subunit 3 0 14468500.0 4407000.0 4250500.0 5811000.0 False True 6036386.994696938 4062698.8554761442 4438561.4813016765 1.0 0.6730348566195788 0.7353010145308813 22.525253869793286 -10.724207680438642 6.848621164069635 1.003821625506139 0.7041679355752346 0.9678426902321944 0.02542005252104215 0.0014970313033254143 6.0284978075051804e-05 0.024840674420954306 0.008204286672809513 1.887088723915453e-11 10.724207680438642 -0.29965368993090435 FMELNLAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FMELNLAQK 9 0 P61758;P61758-2 P61758 VBP1 Prefoldin subunit 3 0 6396100.0 3080100.0 2074800.0 1241200.0 False True 2561239.6215658863 2063622.640584445 1500729.181339613 1.0 0.8057124461173184 0.5859386090638796 21.288410802608226 -6.9695228392530995 0.2693367496725316 1.0550753279130272 0.3299744961118188 0.9999784178740079 0.0007857756362093756 0.07645783732395968 0.009582714168820554 0.004325624983224157 0.020458903296011965 1.0726972339300674e-07 6.9695228392530995 -0.7251008318012084 FMINLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FMINLLK 7 0 Q08AM6;H3BQD9;A0A087WT26 Q08AM6 VAC14 Protein VAC14 homolog 0 2876670.0 861560.0 900010.0 1115100.0 False True 1129513.5033589075 765732.016211502 999720.1487945019 1.0 0.6779308206005462 0.8850891519415831 20.107270087609383 -10.117165627800148 4.792219444513961 1.0000128438478177 0.7815099876650216 0.5972923707443978 0.0845720346316995 1.160614027683044e-05 2.1380571683638523e-06 0.08189133266002967 0.027295506806048392 7.635445334589636e-11 10.117165627800148 -0.2185028561827962 FMINLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FMINLLK 7 0 Q08AM6;H3BQD9;A0A087WT26 Q08AM6 VAC14 Protein VAC14 homolog 0 3753860.0 861560.0 981900.0 1910400.0 False True 1180102.014783548 938516.4112909135 1459202.8659230312 1.0 0.7952841360609442 1.2365056983575062 20.170480149132274 -6.780545099489487 1.5337915500229018 0.8841672863969208 1.2400581944407105 0.7693042773033683 0.0865917060171318 0.24972572139185553 1.1604360859117504 0.04446480948334565 0.10486861058474688 1.6575052036003293e-07 6.780545099489487 0.35589090804378976 FMLQDVLDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FMLQDVLDLR 10 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;H7C044 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 1721500.0 1721500.0 0.0 0.0 False True 1431503.5253808897 0.0 0.0 1.0 0.0 0.0 20.449099792608184 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 FMNPFNMPNLYQK ddPTM_RPMI8226_Bortezomib_1h_R1 3 FMNPFNMPNLYQK 13 0 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 0 76190000.0 19502300.0 28123700.0 28564000.0 False True 25567704.160541862 23927753.585324 25608471.285235565 1.0 0.9358585125625489 1.0015944773311567 24.607819284513234 -9.899488982592972 4.377768346032141 1.0000004636819733 0.9687264951341105 0.2318191130754833 0.026836595300520332 8036295.196921461 9086273.563915186 27.576181219837306 0.009186881391963287 1.2604076121610236e-10 9.899488982592972 -0.031273968547862796 FMNPFNMPNLYQK ddPTM_RPMI8226_Bortezomib_2h_R1 3 FMNPFNMPNLYQK 13 0 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 0 71894830.0 32298100.0 11156730.0 28440000.0 False True 31272814.49458607 15611670.47057834 20990710.818288315 1.0 0.4992090006251604 0.6712127180597133 24.89840572916236 -10.083200367317685 5.6071609466032015 1.0000030004354061 0.585210859342337 0.885764648974555 0.07022022359643869 2.633859274760784e-06 4.3076208079626344e-07 0.06799093040755427 0.022663479712946022 8.256569342967223e-11 10.083200367317685 -0.41479214109306917 FMNPFNMPNLYQK ddPTM_RPMI8226_Carfilzomib_1h_R1 3 FMNPFNMPNLYQK 13 0 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 0 79934900.0 19502300.0 27462200.0 32970400.0 False True 26712827.339840766 26248829.19864883 25183470.566702582 1.0 0.9826301373759898 0.9427482252746332 24.671029346036125 -6.957265452483417 0.4724904272238917 1.0010283066706114 0.922708488657155 0.9996545586373975 0.00044542706182625617 0.08069424534591446 0.024863028676574136 0.0005540423810520595 0.0032910753704718234 1.1034039835143782e-07 6.957265452483417 -0.07831981801345633 FMNPFNMPNLYQK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FMNPFNMPNLYQK 13 0 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 0 56295000.0 30255200.0 13071600.0 12968200.0 False True 25158539.33261916 13001180.69629055 15679790.66181789 1.0 0.516770092428774 0.6232393087101185 24.584544828131488 -10.72582528795072 6.035343706235086 1.0095219322102136 0.5700047005694462 0.9560399662340264 0.04346587553388615 0.005594312411731604 0.000254139119792307 0.04227693310672747 0.014028551005922114 1.880072998054825e-11 10.72582528795072 -0.4395172316407674 FMQASEDLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FMQASEDLLK 10 0 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 9472600.0 2615500.0 1272700.0 5584400.0 False True 2532472.3841523165 1780895.747042821 4121678.1115910453 1.0 0.7032241528820985 1.6275313157938647 21.272115106281987 -6.82031138069781 1.37062910527335 0.8400924114167653 1.6478282755313411 0.8850776644920187 0.1306228539567933 0.19307652738847444 0.7126529622312305 0.07489068872429486 0.17258809706370382 1.512476443393799e-07 6.82031138069781 0.8077358641145759 FMQASEDLLK(ub)EHYVDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FMQASEDLLKEHYVDLK 17 1 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 19609000.0 4682500.0 8673000.0 6253500.0 True False 6138802.845394504 7379022.207089214 5606447.807807747 1.0 1.202029515025907 0.9132803168640374 22.549525906123367 -6.718629839814112 1.76435247422902 1.1230939178735035 0.9137685224143612 0.505966744650427 0.08502958304335097 0.3580009831232623 2.1772463368352897 0.03827790883947505 0.09624317855466381 1.911481768779205e-07 6.718629839814112 -0.2093253954591423 FMQASEDLLK(ub)EHYVDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FMQASEDLLKEHYVDLK 17 1 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 10227700.0 3102400.0 4514200.0 2611100.0 True False 3003916.0101679037 6316743.601242017 1927174.5786790685 1.0 2.1028362909816987 0.6415540821234044 21.518413044823422 -6.704838512857829 1.8138651813564768 1.6815418367694546 0.6455094252907905 0.4405205621519742 0.46512024181147843 0.3855030036702658 2.4691091114867234 0.20432859362703903 0.5223147012795887 1.973156293989742e-07 6.704838512857829 -1.036032411478664 FMQASEDLLK(ub)EHYVDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FMQASEDLLKEHYVDLK 17 1 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 9020300.0 3102400.0 4597500.0 1320400.0 True False 2579783.0596233937 4572732.354967704 1596489.5351601874 1.0 1.7725259253525172 0.6188464294331977 21.2988183202577 -6.726202416912436 1.7366140204756326 1.4668335214729993 0.6199318164898472 0.5418357144786253 0.3248585685324078 0.3433752132659022 2.026851741331464 0.1483361503833333 0.36974428111604707 1.8784411048450152e-07 6.726202416912436 -0.8469017049831521 FMQASEDLLK(ub)EHYVDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FMQASEDLLKEHYVDLK 17 1 Q32Q12;P22392-2;J3KPD9;E7ERL0;E5RHP0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 28026200.0 9560000.0 8382200.0 10084000.0 True False 12375608.45577297 7915723.201454016 8248815.470577595 1.0 0.6396229510446003 0.666538174672914 23.560996122296444 -10.762971403415344 6.9534233015996705 1.0077995299506741 0.6530805628590806 0.9955058875492481 0.010988094033711633 0.0013376139491439651 4.559659457770465e-05 0.01071142949628359 0.003546392099927179 1.725951535373497e-11 10.762971403415344 -0.35471896709159356 FMQTFVLAPEGSVANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FMQTFVLAPEGSVANK 16 0 Q13283;E5RIZ6 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 4666900.0 1825900.0 1525500.0 1315500.0 False True 2393772.582040755 1297901.346352426 1179384.6791670406 1.0 0.5421991028261886 0.49268869065313786 21.190854666322934 -13.999999999999998 0.3141278741244105 5.533773314084512 0.48220227574036656 0.9996810302298439 0.004078716829753644 17.56888133917436 0.178490268869048 52.181963043018634 0.016872065047660565 1.0000000000000041e-14 13.999999999999998 -5.051571038344146 FMQTFVLAPEGSVANK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FMQTFVLAPEGSVANK 16 0 Q13283;E5RIZ6 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 15765700.0 3441300.0 7944700.0 4379700.0 False True 4454830.688164383 7502570.461047415 3582639.5395169305 1.0 1.684142672577946 0.804214523581178 22.08693917054671 -6.699190938329116 1.833778129704191 1.4251600273547311 0.8068727572648758 0.4137436457716007 0.28882773140400875 0.3971994100237477 2.596192758797831 0.1256814701113382 0.323539980290097 1.9989828201133822e-07 6.699190938329116 -0.6182872700898553 FMQTFVLAPEGSVPNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FMQTFVLAPEGSVPNK 16 0 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 10058200.0 2159200.0 4597400.0 3301600.0 False True 2830732.1097225444 3911485.8405248374 2959982.1031835047 1.0 1.3817930093385713 1.045659563834046 21.43274379357245 -10.500182437112537 6.574976551826716 0.9998894473485945 1.2137262865863085 0.3502496362682208 0.1372259044949505 0.00022249723547468627 1.6913894147662787e-05 0.13293676606172608 0.044289470231432745 3.160949539108526e-11 10.500182437112537 0.21383683923771402 FMQTFVLAPEGSVPNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FMQTFVLAPEGSVPNK 16 0 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 8379620.0 2239600.0 820620.0 5319400.0 False True 2168505.1238950626 1148297.8454767668 3926089.561420638 1.0 0.5295343012213859 1.8105050885785354 21.048269421429623 -6.807291362362708 1.4258667171074102 0.7427681753014105 1.8315585938851853 0.8526454386788835 0.20308924063418246 0.2105157053105049 0.8440375949356514 0.11201118042286003 0.2594399839859878 1.5585065707894385e-07 6.807291362362708 1.0887904185837747 FMQTFVLAPEGSVPNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FMQTFVLAPEGSVPNK 16 0 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 9753700.0 2159200.0 2933700.0 4660800.0 False True 2957514.590185987 2804079.4335514284 3560015.0321891047 1.0 0.9481202367881102 1.203718502015988 21.49595385509534 -6.853871951772357 1.2163722898851763 0.9721960627530398 1.2147188760676373 0.9457360310443588 0.025697306046350583 0.15325214544720744 0.4344107008753248 0.016513836001091627 0.038318197645108534 1.4000000404545033e-07 6.853871951772357 0.24252281331459746 FMSVQRPGPYDRPGTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FMSVQRPGPYDRPGTAR 17 2 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 18567400.0 4910100.0 6939000.0 6718300.0 False True 6437188.649476043 5903728.248010154 6023154.762484171 1.0 0.9171283567230377 0.9356809455901883 22.617999318686863 -10.13853114431298 5.116408734016607 1.0000028788801874 0.9264046511565145 0.9545065639411957 0.0075740626890368305 2.487394699821124e-07 4.186580669313118e-08 0.0073338415226489925 0.0024445182214315395 7.2689027027679e-11 10.13853114431298 -0.07359822772367286 FMSVQRPGPYDRPGTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FMSVQRPGPYDRPGTAR 17 2 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 15020800.0 3867800.0 2085000.0 9068000.0 False True 3745018.806126682 2917551.3731313623 6692818.765831177 1.0 0.7790485239642534 1.787125542569246 21.836541532717835 -6.849263316999227 1.23862573389956 0.8821611960262319 1.8268584366085563 0.9392276401221311 0.10665492038232229 0.15827030083214444 0.46763120175460193 0.06739129587836849 0.15587730128961308 1.414935630496047e-07 6.849263316999227 0.9446972405823244 FMSVQRPGPYDRPGTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FMSVQRPGPYDRPGTAR 17 2 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 22178000.0 4910100.0 8120100.0 9147800.0 False True 6725496.660463237 7761327.132420144 6987278.044854838 1.0 1.1540154614968705 1.0389237252812151 22.681209380209754 -9.991790049134195 4.4724974070430354 0.9999970134208213 1.0964695933164796 0.4836754912412228 0.04698600460520578 32355908.87564919 8.121422778087366 995.1664457005332 0.01608455912358148 1.0190839244615389e-10 9.991790049134195 0.09647257989565838 FMSVQRPGPYDRPGTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FMSVQRPGPYDRPGTAR 17 2 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 7016400.0 3867800.0 2085200.0 1063400.0 False True 3216247.0725926254 2073966.6137202044 1285752.023393931 1.0 0.6448405756490513 0.39976780215379504 21.61694680815211 -8.094371422090148 0.17038331016073166 1.319478289407999 3.939593822191086e-09 0.9999032661759629 0.0024235549039577186 0.0930632360678647 0.03165418298236968 0.0984854258249633 0.11490228988214289 8.046899510662122e-09 8.094371422090148 -1.3194782854684053 down FMSVQRPGPYDRPGTAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FMSVQRPGPYDRPGTAR 17 2 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 42469000.0 9375100.0 3833900.0 29260000.0 False True 12136251.760849077 3620540.09473104 23934980.23295326 1.0 0.2983244057618115 1.9721888359440825 23.53281958325133 -6.7928432389132425 1.4850501378798429 0.6092822568440384 1.9913880826474988 0.8103822777692214 0.2988590457037015 0.23113606134748213 1.0069370776434912 0.15838208560683859 0.37004264669538467 1.6112271119052256e-07 6.7928432389132425 1.3821058258034604 FMTFQMSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FMTFQMSLR 9 0 Q8N3U4-2;Q8N3U4 Q8N3U4-2 STAG2 Cohesin subunit SA-2 0 17465200.0 6238500.0 4293100.0 6933600.0 False True 8075861.229219624 4054185.211061804 5671755.94474384 1.0 0.5020127384548388 0.7023097331368962 22.945184689795845 -10.1927560921733 5.41342729599148 1.0000169726983232 0.6021612357958055 0.8402612526361284 0.08177090566421828 1.675106815864427e-05 2.4977783922558353e-06 0.07917771317002698 0.026391446320119572 6.415697929049196e-11 10.1927560921733 -0.39785573690251774 FMVLLWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FMVLLWK 7 0 A6NIL9 A6NIL9 CRYM-AS1 Putative uncharacterized protein CRYM-AS1 0 9226500.0 2178700.0 4303600.0 2744200.0 False True 2856296.798560811 3661519.6553014074 2460256.508225155 1.0 1.2819114796285596 0.8613448397466232 21.44571446730617 -6.726083937795785 1.7375494133902072 1.1703885735058417 0.8617702520567498 0.54101084278981 0.11854967454631168 0.34362384472741087 2.0305471790482557 0.054109693615813206 0.13486682869308486 1.878953628978709e-07 6.726083937795785 -0.30861832144909185 FMVLLWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FMVLLWK 7 0 A6NIL9 A6NIL9 CRYM-AS1 Putative uncharacterized protein CRYM-AS1 0 12113600.0 6242200.0 4110600.0 1760800.0 False True 6044044.7778075235 5751984.016495816 1299593.6571322817 1.0 0.9516779289286385 0.21502052101005598 22.527082918192495 -6.920231158502092 0.8230312513758359 1.0161201058272429 0.09560251408620797 0.994244227248375 0.027251007399855805 0.09803670485995722 0.10491857894143998 0.023508023188045582 0.07057183419133248 1.201624685071727e-07 6.920231158502092 -0.9205175917410349 down FMVLLWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FMVLLWK 7 0 A6NIL9 A6NIL9 CRYM-AS1 Putative uncharacterized protein CRYM-AS1 0 30287200.0 6388200.0 10060000.0 13839000.0 False True 9691366.439977508 8264714.400861248 11103715.58415083 1.0 0.8527914460822337 1.1457327150841488 23.208268662951777 -6.770080957061138 1.5740863506703064 0.9155724869004911 1.1473871155872286 0.7308663969491529 0.06204270608510533 0.26631185609907165 1.3022446236221141 0.03106727318463094 0.07394923749682804 1.6979271114799542e-07 6.770080957061138 0.23181462868673752 FMVLLWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FMVLLWK 7 0 A6NIL9 A6NIL9 CRYM-AS1 Putative uncharacterized protein CRYM-AS1 0 14238400.0 2178700.0 3939000.0 8120700.0 False True 2984224.2671536705 3764961.9554688893 6202757.911066342 1.0 1.2616216538778704 2.07851600810903 21.508924528829063 -6.950548257210006 0.5527937596355353 0.988885199626826 2.3898131920723307 0.9992435961379909 0.012633199927195254 0.08326637009299763 0.03505728594916049 0.013663076663249505 0.06780476965858699 1.1206029019339125e-07 6.950548257210006 1.4009279924455047 up FMVLLWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FMVLLWK 7 0 A6NIL9 A6NIL9 CRYM-AS1 Putative uncharacterized protein CRYM-AS1 0 10356400.0 6242200.0 1445400.0 2668800.0 False True 5190665.876347706 1437613.3433105631 3226833.7408630084 1.0 0.27696125652420284 0.6216608461674857 22.30748819362677 -10.609095468297259 6.576333925123468 1.0014797475436685 0.4493110513475763 0.7728853496294683 0.14072301819546534 0.0030597455190224665 0.0001818741701412155 0.1365518555767453 0.04541815882492337 2.4598268160405265e-11 10.609095468297259 -0.5521686961960922 FMVLLWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FMVLLWK 7 0 A6NIL9 A6NIL9 CRYM-AS1 Putative uncharacterized protein CRYM-AS1 0 20955500.0 6388200.0 8120600.0 6446700.0 False True 8269650.830247783 7668681.471418898 5273466.748727948 1.0 0.9273283272576964 0.6376891669282172 22.979394985044227 -6.94495820315873 0.6117052390089663 1.0031962770082579 0.546693674115594 0.9987437818957425 0.005546989876220344 0.0855758524670056 0.044844847636349175 0.005629320472104697 0.024437820957423348 1.1351200552592266e-07 6.94495820315873 -0.45650260289266387 FMYDPQTDQNIK(ub)INDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FMYDPQTDQNIKINDR 16 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 20568900.0 5047200.0 6757300.0 8764400.0 True False 6616928.07715433 5749137.179749093 7857543.962061284 1.0 0.8688529046580723 1.1874912150232246 22.657730167558533 -6.794969453898733 1.4766668501127886 0.9271723103916544 1.1913475061701047 0.8169495316686466 0.05594474921623902 0.2280244079158856 0.9821136712716049 0.029814254789610965 0.06955090191443639 1.6033581589162002e-07 6.794969453898733 0.2641751957784503 FMYDPQTDQNIK(ub)INDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FMYDPQTDQNIKINDR 16 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 21348600.0 7149500.0 6221100.0 7978000.0 True False 6922543.035938446 8705217.672607914 5888322.465130251 1.0 1.2575173064890597 0.8506010630141222 22.7228706868643 -6.735692980601523 1.7025596303905595 1.153981912208024 0.850583841334312 0.5854191903951405 0.10821433942369121 0.32566258226554884 1.8518192240024995 0.05031870741147197 0.12406167816378762 1.8378371216486333e-07 6.735692980601523 -0.30339807087371196 FMYDPQTDQNIK(ub)INDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FMYDPQTDQNIKINDR 16 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 32571600.0 15195000.0 7984400.0 9392200.0 True False 23051925.903299548 6559521.437598061 7535827.553252497 1.0 0.2845541611193172 0.32690663612509063 24.45838395174554 -10.130949304859149 5.864405871950344 1.000005559838166 0.30573039862217866 0.9972167503308788 0.017290325518110803 1.2568788303357446e-06 1.8623770270693175e-07 0.016741419561939645 0.005580428565165827 7.396916141290732e-11 10.130949304859149 -0.6942751612159874 FMYDPQTDQNIK(ub)INDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FMYDPQTDQNIKINDR 16 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 16356700.0 5047200.0 5274500.0 6035000.0 True False 6913286.2354514245 5041455.149560975 4609657.29472649 1.0 0.7292414891934208 0.6667823575838804 22.720940229081425 -13.999999999999998 0.20606804161064585 2.5411411997205073 0.6285604897907593 0.999488183018397 0.003271880996426969 12.657526238008721 0.14390828319684595 7.883372957093276 0.03804391420130547 1.0000000000000041e-14 13.999999999999998 -1.912580709929748 FMYDPQTDQNIK(ub)INDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FMYDPQTDQNIKINDR 16 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 16917600.0 7149500.0 6699700.0 3068400.0 True False 5945126.026552817 6663607.386313679 3709988.2533213575 1.0 1.1208521663883821 0.6240386220159798 22.503275962298577 -6.842419829924797 1.271116746845373 1.0642835220712787 0.6069000769337898 0.9285353324636383 0.05655306812593424 0.16599022235881736 0.5199263687252998 0.03487204457330253 0.08039786165608089 1.4374083721814148e-07 6.842419829924797 -0.45738344513748896 FMYDPQTDQNIK(ub)INDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FMYDPQTDQNIKINDR 16 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 30729700.0 15195000.0 9675700.0 5859000.0 True False 19670227.03822908 9137238.789376136 4792722.11841671 1.0 0.46452126717286557 0.24365362479558855 24.229510273837988 -11.383003770602096 0.16301452726043653 2.153880259212746 1.4495910101073282e-18 0.9995605923721806 0.006656635782180223 3.935686388717156 0.09955469031729204 1.814969923112168 0.18418237593607537 4.139960804354352e-12 11.383003770602096 -2.153880259212746 FMYDPQTDQNIK(ub)INDRFEFPEQLPLDEFLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FMYDPQTDQNIKINDRFEFPEQLPLDEFLQK 31 2 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 90476000.0 27123000.0 31612000.0 31741000.0 True False 41147573.95690655 25970591.6143167 25467377.43742548 1.0 0.631157298399061 0.6189278003144781 25.294304036692743 FNADEFEDMVAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNADEFEDMVAEK 13 0 F8W7C6;P27635;X1WI28;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 0 16256770.0 948270.0 8025800.0 7282700.0 False True 1243191.1530597438 6828381.924323373 6529156.064591268 1.0 5.4926242899310775 5.251932535492792 20.245616711546134 -10.26541421954435 4.361011243382917 0.9972771349955083 5.372278412784833 0.9977323181842644 0.09826199782175556 17379763.529428255 2210.221043379769 477537.33588693273 0.033637695386190804 5.427324395167998e-11 10.26541421954435 4.375001277789324 FNADEFEDMVAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNADEFEDMVAEK 13 0 F8W7C6;P27635;X1WI28;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 0 13829800.0 4803300.0 1095100.0 7931400.0 False True 4650821.870693485 1532379.1408710575 5853928.403100291 1.0 0.32948566586201333 1.258686865645837 22.149054254147256 -6.713146056713497 1.7845355934045177 0.5891017093715623 1.256660336920544 0.47980286135113714 0.2824165794231783 0.3687767932606415 2.29128470992085 0.1258647411412334 0.31847652561060424 1.9357708392223777e-07 6.713146056713497 0.6675586275489818 FNADEFEDMVAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNADEFEDMVAEK 13 0 F8W7C6;P27635;X1WI28;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 0 21718770.0 948270.0 9571500.0 11199000.0 False True 1298871.0450331916 9148599.481282175 8554026.850644901 1.0 7.0435009820766235 6.585739888001207 20.308826773069026 -10.057617787662187 5.846024295351133 0.999982003016701 6.814620435039539 0.9953731841287402 0.1868801840993773 4.38494616428053e-05 7.069627763588933e-06 0.1809465101181308 0.06031532006243104 8.757541667778763e-11 10.057617787662187 5.814638432022838 FNADEFEDMVAEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 2 FNADEFEDMVAEKR 14 1 F8W7C6;P27635;X1WI28;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 58770000.0 10879900.0 11331600.0 36558500.0 True False 14263654.261101488 9640969.450230852 32775777.113894545 1.0 0.6759116053817154 2.297852746142172 23.76584030300501 -6.8547637940388375 1.2119747885871233 0.8260806741600872 2.3688655957494924 0.9469409908732018 0.16142720348226103 0.1522972776580143 0.4281148370106408 0.10408471202639623 0.24169588649990173 1.3971280304869317e-07 6.8547637940388375 1.5427849215894052 up FNADEFEDMVAEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 2 FNADEFEDMVAEKR 14 1 F8W7C6;P27635;X1WI28;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 95775900.0 18530900.0 21226800.0 56018200.0 True False 17942646.722801823 29702771.93629964 41345352.91002253 1.0 1.6554286775625386 2.3043062458271635 24.096889382351627 -6.971249116374062 0.2263725117607503 0.7238333324585512 3.2543618334709605 0.9999905540486475 0.0016365373614339437 0.07589942097563072 0.007563611958262466 0.017127589021382082 0.06490916019318858 1.0684418327322705e-07 6.971249116374062 2.5305285010124092 FNADEFEDMVAEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 2 FNADEFEDMVAEKR 14 1 F8W7C6;P27635;X1WI28;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 328235300.0 31923300.0 92708000.0 203604000.0 True False 48429980.00584427 76163533.0690898 163361580.1571968 1.0 1.5726525813122119 3.373149857536245 25.52939707153936 -6.950391023498671 0.5545330352999428 0.9757428826572286 4.0553048033580055 0.9992316209440498 0.028028332822162275 0.0833290848119882 0.035315319558585585 0.030247133648374978 0.1494987742504833 1.1210086829416123e-07 6.950391023498671 3.079561920700777 FNADEFEDMVAEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNADEFEDMVAEKR 14 1 F8W7C6;P27635;X1WI28;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 80055400.0 8142400.0 8394400.0 63518600.0 True False 11152865.320086304 8023507.651431333 48516814.88663036 1.0 0.7194122246756626 4.350165943387804 23.410911069605685 -6.888241052702437 1.032761735112358 0.7966088745267585 4.651857287710276 0.9797472659861467 0.23472972590438979 0.12058066546240781 0.23029201855029405 0.17356914175799726 0.43004742998934686 1.2934777046657374e-07 6.888241052702437 3.855248413183517 up FNADEFEDMVAEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FNADEFEDMVAEKR 14 1 F8W7C6;P27635;X1WI28;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 86277600.0 18530900.0 21769100.0 45977600.0 True False 15409264.40806315 21651825.537471976 55591303.58359671 1.0 1.4051173997729771 3.6076545973542804 23.877294657785903 -6.937955372945088 0.6783161399845807 0.9741849338626604 4.167512429417783 0.9978836753351047 0.05270958041483787 0.08871187377680864 0.058950515075965194 0.0505463608623849 0.1913383838339789 1.1535717899895769e-07 6.937955372945088 3.193327495555123 up FNADEFEDMVAEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FNADEFEDMVAEKR 14 1 F8W7C6;P27635;X1WI28;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 421343100.0 31923300.0 99409800.0 290010000.0 True False 41325341.15231981 93877557.24176264 237231155.75388846 1.0 2.2716704720172114 5.7405734384499185 25.30052339363181 -6.953567079715244 0.5182074154321141 0.9402270765431345 7.226348438188499 0.999452291868216 0.04688652735307054 0.08208425183423995 0.030273494720759304 0.053269290719216995 0.2864840689018657 1.1128404937980825e-07 6.953567079715244 6.286121361645364 FNAHGDANTIVCNSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNAHGDANTIVCNSK 15 0 P09382 P09382 LGALS1 Galectin-1 0 46477300.0 7838400.0 20849200.0 17789700.0 False True 10276218.30717357 17738580.629545074 15948992.494852094 1.0 1.7261778700402088 1.552029357309245 23.292806108388447 -10.052754707735934 4.47830647388923 0.9999661671144354 1.6391036135345844 0.947249952605762 0.07109583279458767 49646739.47711981 67265182.11486953 23879.300984705038 0.026018411281315844 8.856156699181891e-11 10.052754707735934 0.639137446420149 FNAHGDANTIVCNSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNAHGDANTIVCNSK 15 0 P09382 P09382 LGALS1 Galectin-1 0 16412300.0 7531500.0 1889400.0 6991400.0 False True 7292416.65503466 2643847.273090837 5160142.602495821 1.0 0.36254747886155597 0.7076039187822978 22.79796556199301 -10.651892844629192 6.790768907061347 1.0020112543663482 0.5350756988220554 0.707653592960599 0.14086870171118948 0.004303750002813004 0.00022061772013300785 0.13685001764838395 0.04546517797744145 2.2289850486261948e-11 10.651892844629192 -0.4669355555442928 FNAHGDANTIVCNSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FNAHGDANTIVCNSK 15 0 P09382 P09382 LGALS1 Galectin-1 0 120069200.0 4240400.0 110209200.0 5619600.0 False True 6432996.814764818 90541507.19159018 4508883.596841827 1.0 14.074545627596468 0.7008993983166873 22.617059543672624 -6.65140171784183 2.0037416544282047 9.4751256712918 0.7577358871929785 0.19950816744734134 5.578551987781354 0.5052422181421167 3.8899199419709074 2.256760066471978 6.178595447833153 2.231507147179134e-07 6.65140171784183 -8.71738978409882 FNAHGDANTIVCNSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNAHGDANTIVCNSK 15 0 P09382 P09382 LGALS1 Galectin-1 0 47455600.0 7838400.0 19877360.0 19739840.0 False True 10736468.304795211 18999112.509560596 15077696.346766148 1.0 1.7695867924348134 1.4043441398725147 23.35601616991134 -10.192841706515209 4.6601946887657215 0.9998983578502176 1.586965466157831 0.774952487814671 0.1491096885275176 0.000157501485406182 2.727920703432519e-05 0.14439965929063328 0.04812494503339157 6.414433299536321e-11 10.192841706515209 0.5870671083076133 FNAHGDANTIVCNSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNAHGDANTIVCNSK 15 0 P09382 P09382 LGALS1 Galectin-1 0 11658600.0 7531500.0 1632900.0 2494200.0 False True 6262775.952022162 1624103.2435947256 3015725.688122196 1.0 0.259326416278763 0.48153178578078637 22.578370837427286 -10.070566839015324 5.202944943556372 1.0000091887213172 0.37042910102969884 0.914554235684191 0.09071496223542647 253836660.062962 173487687.23617154 30307.747149958566 0.03319827878191848 8.500278616897936e-11 10.070566839015324 -0.6295800876916183 FNAHGDANTIVCNSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNAHGDANTIVCNSK 15 0 P09382 P09382 LGALS1 Galectin-1 0 15611500.0 4240400.0 5894500.0 5476600.0 False True 5489281.390780296 5566465.89331807 4479914.994661374 1.0 1.0140609484271315 0.8161204856770075 22.388185865765074 -6.8898442589216735 1.0233268331090823 1.0106753527068066 0.799149093823526 0.9807975848851634 0.01249631445366212 0.11926866666593097 0.22259794486081613 0.009306565989632459 0.0231879470632984 1.2887116099537646e-07 6.8898442589216735 -0.2115262588832807 FNAHGDANTIVCNSK(ub)DGGAWGTEQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNAHGDANTIVCNSKDGGAWGTEQR 25 1 P09382 P09382 LGALS1 Galectin-1 1 17114300.0 6658700.0 5762800.0 4692800.0 True False 8729620.182942526 4903012.703218458 4207234.07251622 1.0 0.5616524660258221 0.4819492697674358 23.057487454323713 -13.999999999999998 0.23975453681033668 3.897994351291946 0.44662651502057205 0.9995245555109864 0.004966265517871501 13.61477859267887 0.15497569224900576 18.88758427973659 0.03900226074886428 1.0000000000000041e-14 13.999999999999998 -3.451367836271374 FNAHGDANTIVCNSK(ub)DGGAWGTEQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FNAHGDANTIVCNSKDGGAWGTEQR 25 1 P09382 P09382 LGALS1 Galectin-1 1 68810000.0 25059000.0 19065000.0 24686000.0 True False 38016335.05829442 15662701.794475103 19806801.279741842 1.0 0.41199925691042666 0.5210076470909151 25.180116120761927 -9.949177927182774 5.853672549756492 1.0000003766719603 0.4665034520009102 0.9696381934155779 0.04450248893824979 2.1877775341956944e-07 3.9268585797838256e-08 0.04308937980697154 0.014363116543427961 1.12414432613601e-10 9.949177927182774 -0.5334969246710501 FNAHGDANTIVCNSK(ub)DGGAWGTEQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNAHGDANTIVCNSKDGGAWGTEQR 25 1 P09382 P09382 LGALS1 Galectin-1 1 19103800.0 6658700.0 5681200.0 6763900.0 True False 9120601.334601438 5430185.798783923 5166406.126893211 1.0 0.5953758529257344 0.5664545502381592 23.120697515846604 -13.999999999999996 0.374536656622326 6.7994411872505935 0.5636669364807342 0.9997985635818121 0.002808910906104361 23.359280322068447 0.19906032412145788 108.9796982848277 0.007969980307013694 1.0000000000000082e-14 13.999999999999996 -6.235774250769859 FNAHGDANTIVCNSK(ub)DGGAWGTEQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNAHGDANTIVCNSKDGGAWGTEQR 25 1 P09382 P09382 LGALS1 Galectin-1 1 15112400.0 8006300.0 3022300.0 4083800.0 True False 6657593.189228588 3006018.270020418 4937703.6986422185 1.0 0.45151726526094993 0.7416649768614576 22.6665692869316 -10.616975047897059 7.9974990827571935 1.0003487415950694 0.5965911210612038 0.7204717920691424 0.11845230724290923 0.0007371583279095597 3.5304708306297884e-05 0.11478536224496781 0.038230317772636 2.4155996171404304e-11 10.616975047897059 -0.40375762053386555 FNAHGDANTIVCNSK(ub)DGGAWGTEQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNAHGDANTIVCNSKDGGAWGTEQR 25 1 P09382 P09382 LGALS1 Galectin-1 1 63069000.0 25059000.0 22063000.0 15947000.0 True False 32439369.48673793 20835174.655064296 13044809.63003776 1.0 0.6422805062096618 0.40212895122301384 24.951242442854376 -8.24060657591875 0.16430876861890287 1.351683841522215 5.734320809978969e-08 0.9998968192843226 0.002495232814674151 0.08640077037868837 0.034208859370773066 0.1208944933120314 0.1257349336301403 5.74636785604271e-09 8.24060657591875 -1.3516837841790068 down FNALFAQGNYSEAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNALFAQGNYSEAAK 15 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 22982300.0 6405200.0 6362100.0 10215000.0 False True 8397279.228045031 5412899.479271566 9158049.789199034 1.0 0.6446015825213592 1.0905972685311212 23.001490530544118 -6.694404528015904 1.8504252017640512 0.7781173857615598 1.0891573041901668 0.3912421257633646 0.1501765450398282 0.4072848428393813 2.707036359831927 0.06483895289048082 0.16793487930610473 2.0211356942033092e-07 6.694404528015904 0.311039918428607 FNALFAQGNYSEAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNALFAQGNYSEAAK 15 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 16867200.0 6405200.0 4851300.0 5610700.0 False True 8773375.534021523 4636953.524896224 4285568.215993692 1.0 0.5285255950705607 0.4884742707496167 23.06470059206701 -13.999999999999998 0.3492326780077094 6.770710145076603 0.48288451892902756 0.9997532443126506 0.0036486240965330975 20.583919491878294 0.19018260436992618 88.08712523414194 0.011981366955946126 1.0000000000000041e-14 13.999999999999998 -6.287825626147576 FNAPGAQQFCFLLSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNAPGAQQFCFLLSTR 16 0 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;K7EMY3;Q8TDI0;Q12873-3;Q12873;Q12873-2;A0A5F9ZHX5;F2Z2R5;F6T542 A0A2R8YFD8 CHD4;CHD5;CHD3 Chromodomain-helicase-DNA-binding protein 4;Chromodomain-helicase-DNA-binding protein 5;Chromodomain-helicase-DNA-binding protein 3 0 3051140.0 1252800.0 1095400.0 702940.0 False True 1642432.9321324588 931970.589835758 630206.5118766094 1.0 0.5674329658171982 0.3837030417177391 20.64740302939664 -13.999999999997359 0.11705906684131671 3.0670025277123716 0.07849246890476486 0.9997074862212778 0.004418529667952323 11.975977418759374 0.10490518319173639 5.78243982231711 0.27082482731043983 1.0000000000060821e-14 13.999999999997359 -2.9885100588076066 FNAPGAQQFCFLLSTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FNAPGAQQFCFLLSTR 16 0 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;K7EMY3;Q8TDI0;Q12873-3;Q12873;Q12873-2;A0A5F9ZHX5;F2Z2R5;F6T542 A0A2R8YFD8 CHD4;CHD5;CHD3 Chromodomain-helicase-DNA-binding protein 4;Chromodomain-helicase-DNA-binding protein 5;Chromodomain-helicase-DNA-binding protein 3 0 94773000.0 26929000.0 24618000.0 43226000.0 False True 40853261.77360677 20224725.558688063 34682362.153371185 1.0 0.4950577917319257 0.8489496468009736 25.283947933690104 -10.098310580220968 6.025559364056703 1.000001209722595 0.6720037192664438 0.5338739980614695 0.1444757448410544 2.347839418304264e-06 3.514796847494868e-07 0.13988855325622676 0.04662934614168854 7.974242154396794e-11 10.098310580220968 -0.32799749045615123 FNAPGAQQFCFLLSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNAPGAQQFCFLLSTR 16 0 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;K7EMY3;Q8TDI0;Q12873-3;Q12873;Q12873-2;A0A5F9ZHX5;F2Z2R5;F6T542 A0A2R8YFD8 CHD4;CHD5;CHD3 Chromodomain-helicase-DNA-binding protein 4;Chromodomain-helicase-DNA-binding protein 5;Chromodomain-helicase-DNA-binding protein 3 0 3966730.0 1252800.0 727230.0 1986700.0 False True 1715994.0156470016 695098.5739719834 1517482.3773708576 1.0 0.40507051168817865 0.8843168236800075 20.71061309091953 -10.049154824386477 7.189255734312689 1.0000000518482162 0.644693667684109 0.4229227379462315 0.19565148758177556 1.6264400454303512e-07 2.1203075682774788e-08 0.18943876649466376 0.06314624608874363 8.929870803700234e-11 10.049154824386477 -0.3553063841641072 FNASQLITQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNASQLITQR 10 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6 Q99623 PHB2 Prohibitin-2 0 26890500.0 4605800.0 8781700.0 13503000.0 False True 6038248.402630642 7471504.590798502 12105839.089922125 1.0 1.2373629060280864 2.0048594033740077 22.525698677264142 -6.949755101934435 0.5615267271603395 0.9900412335385449 2.2889571551764063 0.9991819177080481 0.012265742170698453 0.08358425045592421 0.03637063456896583 0.01312406183106663 0.06382112307411957 1.122651337401059e-07 6.949755101934435 1.2989159216378614 up FNASQLITQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNASQLITQR 10 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6 Q99623 PHB2 Prohibitin-2 0 17123300.0 6184500.0 2164500.0 8774300.0 False True 5988176.4327241415 3028796.1377183837 6476047.606642312 1.0 0.505796075273708 1.0814724114092658 22.51368529821321 -6.679483999105968 1.903376885923219 0.6871573341402546 1.0792847863076656 0.32173096724294503 0.2094812339617723 0.4397803177273658 3.0798612149481372 0.08831808380336273 0.2331164775851645 2.0917799740114206e-07 6.679483999105968 0.39212745216741096 FNASQLITQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNASQLITQR 10 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6 Q99623 PHB2 Prohibitin-2 0 19875600.0 4605800.0 7858300.0 7411500.0 False True 6308688.727064934 7511094.322076967 5661056.344633872 1.0 1.190595169144039 0.8973427901661004 22.588908738787033 -6.7312800674633095 1.718420935045812 1.1145354742903708 0.8974718595037678 0.5652299967565911 0.08011408731353657 0.3338554174318768 1.931951243224545 0.03693518801546818 0.09152459813586765 1.8566067819227598e-07 6.7312800674633095 -0.21706361478660297 FNASQLITQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNASQLITQR 10 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6 Q99623 PHB2 Prohibitin-2 0 9951700.0 6184500.0 2406500.0 1360700.0 False True 5142685.769804299 2393535.706847148 1645216.0788340403 1.0 0.46542522992576935 0.3199137867792859 22.294090573647487 -13.999999999999998 0.1826021217378039 3.796243045248315 0.20737938863970104 0.999495230164557 0.006569292315659705 12.239490279607345 0.13548361577845966 12.150444588151004 0.10628815602039073 1.0000000000000041e-14 13.999999999999998 -3.588863656608614 FNAVLCSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNAVLCSR 8 0 P50995-2;P50995;H0Y6E1 P50995-2 ANXA11 Annexin A11 0 48003500.0 13521000.0 9318500.0 25164000.0 False True 17726161.937550247 7928216.123228515 22560270.670132585 1.0 0.44726072971463515 1.2727104011355101 24.079376862429474 -6.726265343118472 1.7370034057723658 0.6659895468205446 1.2718816469290133 0.5418374739141589 0.23243374764634728 0.34326458217833533 2.0272600652567405 0.10612221622010432 0.26444013846703684 1.8781689517002573e-07 6.726265343118472 0.6058921001084687 FNAVLCSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNAVLCSR 8 0 P50995-2;P50995;H0Y6E1 P50995-2 ANXA11 Annexin A11 0 30183200.0 13521000.0 7820700.0 8841500.0 False True 18520079.09128598 7475155.614403549 6753319.796408329 1.0 0.4036243893753531 0.3646485397346863 24.142586923952365 -13.963034607908652 0.3878542934683564 9.999925317771858 0.3616583030515266 0.9998191726445727 0.003909859341316679 24.30471410459612 0.2037339666043795 183.01485828672955 0.010326416946223462 1.0888433225056423e-14 13.963034607908652 -9.63826701472033 FNAVLCSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNAVLCSR 8 0 P50995-2;P50995;H0Y6E1 P50995-2 ANXA11 Annexin A11 0 13632500.0 7062200.0 2057900.0 4512400.0 False True 5872532.208507061 2046813.68423883 5455921.977019719 1.0 0.34854022278052 0.9290578209373066 22.48555129019272 -10.546484182936876 9.112592009114715 1.0000266099652348 0.6387990218589289 0.34045009228260703 0.23699531703169593 0.00012813281046058258 6.376559044616342e-06 0.2294865634860325 0.07648990966607544 2.8412916633213278e-11 10.546484182936876 -0.36122758810630595 FNAVLCSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNAVLCSR 8 0 P50995-2;P50995;H0Y6E1 P50995-2 ANXA11 Annexin A11 0 35648000.0 0.0 22857000.0 12791000.0 False True 0.0 21584987.85708221 10463169.246743156 0.0 FNECGHVLYADIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNECGHVLYADIK 13 0 P52272-2;P52272;A0A087X0X3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 29122000.0 11270000.0 6795000.0 11057000.0 False True 14775079.138835246 5781212.486702543 9912927.706233347 1.0 0.3912813212287328 0.6709221394407235 23.816662522052543 -10.44721898569352 6.143781648217773 1.0001883270826792 0.5311017303347578 0.789421478885486 0.11416288597896128 0.00029460933332821896 2.650737765294943e-05 0.1105813437453126 0.03684591301262441 3.570927347386808e-11 10.44721898569352 -0.4690865967479214 FNECGHVLYADIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNECGHVLYADIK 13 0 P52272-2;P52272;A0A087X0X3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 33450700.0 11270000.0 9306700.0 12874000.0 False True 15436823.560298286 8895499.220858674 9833426.348352754 1.0 0.576251920358594 0.6370109958141378 23.879872583575434 -10.431570613756008 5.993733325015489 1.0001540939084368 0.6066314580864364 0.9824214843542222 0.02480478868489103 5.109616630633424e-05 4.8458293911878455e-06 0.024026432233087893 0.008005711123564708 3.7019400911441166e-11 10.431570613756008 -0.3935226358220004 FNEENYGVK(ub)TTYDSSLSSYTVPLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNEENYGVKTTYDSSLSSYTVPLEK 25 1 Q8WWM7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7-3;H3BUF6;Q8WWM7-7;H3BSK9 Q8WWM7 ATXN2L Ataxin-2-like protein 1 6830100.0 2246800.0 1620500.0 2962800.0 True False 2175476.5638361396 2267574.10079586 2186753.7979052262 1.0 1.042334419267344 1.0051837993828814 21.05290004429524 -6.614561205125439 2.1361314687414987 1.028194924539556 1.0053189899853197 0.06507137913632355 0.018230207500307037 0.6001194849218071 5.195334742174593 0.007030024763827572 0.020234150751471537 2.429063090012919e-07 6.614561205125439 -0.02287593455423642 FNFFALLPHQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNFFALLPHQR 11 0 Q7L592;Q7L592-2 Q7L592 NDUFAF7 NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 0 10730000.0 4337200.0 3556200.0 2836600.0 False True 4199517.960063246 4976209.205338006 2093609.3638240758 1.0 1.184947713680706 0.4985356375979269 22.0017923075638 -6.834967116704452 1.3055329915247398 1.0985369437444636 0.47811318706788375 0.9154569808779803 0.08431752542514162 0.1747579475738451 0.5807500134423726 0.050680695275103486 0.11664957904043549 1.4622878897121333e-07 6.834967116704452 -0.6204237566765799 down FNFFALLPHQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNFFALLPHQR 11 0 Q7L592;Q7L592-2 Q7L592 NDUFAF7 NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 0 10912800.0 4337200.0 2805200.0 3770400.0 False True 3606573.9705384756 2790087.830811394 4558773.207640096 1.0 0.7736117028523951 1.2640176646534864 21.782197582998077 -6.781182806388326 1.5312786243168044 0.8720105417028534 1.2680464693342801 0.7715501887040719 0.09578582899666463 0.2487396559433776 1.1521019268503934 0.04926434581493667 0.11612797405990084 1.6550731514117774e-07 6.781182806388326 0.3960359276314267 FNFLNPNDPYHAYYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNFLNPNDPYHAYYR 15 0 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 73086600.0 24746400.0 18397000.0 29943200.0 False True 32442770.044478517 15652239.310944358 26844964.899456136 1.0 0.4824569322991036 0.8274560052255747 24.951393669920208 -9.92378797901023 5.539268872908691 1.000000377090977 0.6549564687614612 0.5714916833286197 0.140845281736957 6.558861616349651e-07 1.274827342513358e-07 0.13637300699564595 0.04545761921280949 1.191823710032867e-10 9.92378797901023 -0.3450439083295159 FNFLNPNDPYHAYYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNFLNPNDPYHAYYR 15 0 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 67469700.0 22824000.0 8514900.0 36130800.0 False True 22099464.61322598 11914943.974616904 26667059.579233885 1.0 0.5391507976843071 1.206683512290805 24.397508083185713 -6.72095590367538 1.7556980704544307 0.7199110147040558 1.2057104545300372 0.5170645082624615 0.19390515792606017 0.3534844005781372 2.12992294175608 0.08767249493696007 0.21985845933190198 1.9012713167323962e-07 6.72095590367538 0.4857994398259814 FNFLNPNDPYHAYYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FNFLNPNDPYHAYYR 15 0 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 44217100.0 8221200.0 28179000.0 7816900.0 False True 12472161.450227477 23150237.2864681 6271886.288731026 1.0 1.8561527910662083 0.50287083868824 23.572208172947985 -6.735709549899251 1.7021784738744221 1.5119111527527018 0.5027588176758431 0.5856540380309794 0.35977409454085035 0.3256210604382724 1.850701298478056 0.16731760562446438 0.4125678086662508 1.8377670054237628e-07 6.735709549899251 -1.0091523350768588 FNFLNPNDPYHAYYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNFLNPNDPYHAYYR 15 0 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 71045600.0 24746400.0 19183000.0 27116200.0 False True 33895812.82631463 18335431.630302045 20711912.035668984 1.0 0.5409350035136948 0.6110463301705964 25.0146037314431 -10.642273474012761 6.598128347581278 1.0018494810439207 0.5759906668421785 0.9799057806757481 0.028622829249833528 0.0007815053526594373 4.23703315039231e-05 0.027812825383153484 0.00923797841716199 2.2789065990206838e-11 10.642273474012761 -0.4258588142017422 FNFLNPNDPYHAYYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNFLNPNDPYHAYYR 15 0 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 51106000.0 22824000.0 15805000.0 12477000.0 False True 18979167.2746404 15719855.327953134 15085883.012870088 1.0 0.8282689698908815 0.7948653802650002 24.17791335861999 -13.999999999999966 0.23019848690044956 2.0850839658087112 0.7786549094491367 0.9995100617661472 0.001989196216437421 13.297522408734173 0.15191540746266385 6.595716794279521 0.017318141448684547 1.0000000000000778e-14 13.999999999999966 -1.3064290563595744 FNFLNPNDPYHAYYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNFLNPNDPYHAYYR 15 0 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 42400200.0 8221200.0 20160000.0 14019000.0 False True 10642505.464079574 19038078.27793572 11467685.847087195 1.0 1.7888718349445776 1.0775362893439668 23.343334495040434 -10.22758560905584 4.415069352906415 0.9998315664688063 1.4332040621519113 0.3308842051970282 0.2904015204635013 32153568.493679237 74484444.98550019 32743.95661680825 0.09941215582522633 5.921263541596107e-11 10.22758560905584 0.433372495683105 FNFSGSK(ub)VQTPEVDVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNFSGSKVQTPEVDVK 16 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 14177000.0 5620500.0 6288200.0 2268300.0 True False 7368529.928999423 5350025.071211617 2033598.0750700098 1.0 0.7260641027128325 0.2759842322233946 22.81294539004323 -7.055392687591128 0.40010832933020396 1.0262655169041615 2.032441188994742e-12 0.999852415131516 0.0036260624378646987 0.07348006348352941 0.018270052156904408 0.0060796070082655244 0.03551834440131391 8.802525916699896e-08 7.055392687591128 -1.026265516902129 down FNFSGSK(ub)VQTPEVDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNFSGSKVQTPEVDVK 16 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 24128400.0 9430500.0 8170700.0 6527200.0 True False 9131133.93949472 11433303.119637622 4817530.50819732 1.0 1.2521230326263613 0.5275938936083444 23.122362600103607 -6.812711460529731 1.4031202656846797 1.136969377172982 0.5141177300707536 0.8667924185458752 0.10960606234116921 0.20312141868601427 0.7876293034286243 0.06141438208688725 0.14189665334986323 1.5391769093157748e-07 6.812711460529731 -0.6228516471022285 FNFSGSK(ub)VQTPEVDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNFSGSKVQTPEVDVK 16 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 25965400.0 9430500.0 13456000.0 3078900.0 True False 7841878.591986337 13383509.857193116 3722683.7547748457 1.0 1.7066713926009778 0.47471836130937795 22.902767875537883 -6.751127014930426 1.6455579689287212 1.4149625871481688 0.4720394705561945 0.653860610781035 0.29696657162910045 0.29807960984342274 1.5884027436319434 0.14253629253440034 0.34564683902531307 1.7736706725399393e-07 6.751127014930426 -0.9429231165919743 FNFSGSK(ub)VQTPEVDVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNFSGSKVQTPEVDVK 16 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 21665400.0 9025500.0 6640000.0 5999900.0 True False 11683687.669202812 6270478.162970898 4907979.764172801 1.0 0.5366865616837169 0.4200711199350022 23.477992361579343 -13.999999999999998 0.19372162406963356 3.5164084484341336 0.33947207305933796 0.9994877893955679 0.005668445986641752 12.41369804637728 0.1395769427596236 11.806966818440804 0.07788711140643845 1.0000000000000041e-14 13.999999999999998 -3.1769363753747957 FNGDSK(ub)VSISFENYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNGDSKVSISFENYR 15 1 B4E1Q4;O14730-2;O14730 B4E1Q4 RIOK3 Serine/threonine-protein kinase RIO3 1 8692900.0 1324800.0 1589100.0 5779000.0 True False 1282744.949158858 2223635.9170470233 4265306.533716182 1.0 1.7334980882248971 3.32513999490943 20.290802914215956 -6.95841898672981 0.4571701318327537 0.9522720275442682 4.170224691705556 0.9997069945557022 0.01661320873117622 0.0802707860908707 0.02325509899413881 0.021514291919702246 0.13152831942893564 1.1004771090931985e-07 6.95841898672981 3.217952664161288 FNGGGHINHSIFWTNLSPNGGGEPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNGGGHINHSIFWTNLSPNGGGEPK 25 0 P04179-4;P04179;F5H3C5;F5H4R2;F5GYZ5;P04179-3 P04179-4 SOD2 Superoxide dismutase [Mn], mitochondrial 0 28719500.0 7037100.0 13040000.0 8642400.0 False True 9225706.247373348 11094482.82952188 7748167.351754646 1.0 1.2025618995489469 0.8398454431562491 23.13722792608883 -6.755146449088994 1.6307699453853823 1.1183659793680367 0.8388298906528854 0.6708456929698108 0.08514880901635657 0.29114165053944757 1.5248043635514168 0.0412208715653486 0.09953960801925013 1.757330921855838e-07 6.755146449088994 -0.27953608871515134 FNGGGHINHSIFWTNLSPNGGGEPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNGGGHINHSIFWTNLSPNGGGEPK 25 0 P04179-4;P04179;F5H3C5;F5H4R2;F5GYZ5;P04179-3 P04179-4 SOD2 Superoxide dismutase [Mn], mitochondrial 0 30759800.0 12617000.0 5377800.0 12765000.0 False True 12216480.241196616 7525183.584856518 9421463.558208542 1.0 0.6159862281346774 0.7712093313454826 23.542325346257112 -10.107653945651403 5.1374590842013586 1.0000079781200473 0.6935977812644607 0.8385870653001067 0.06336956652816587 5.790825508437487e-06 1.0059186743661236e-06 0.06135891569623345 0.020452439651397075 7.804517420590634e-11 10.107653945651403 -0.30641019685558657 FNGGGHINHSIFWTNLSPNGGGEPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FNGGGHINHSIFWTNLSPNGGGEPK 25 0 P04179-4;P04179;F5H3C5;F5H4R2;F5GYZ5;P04179-3 P04179-4 SOD2 Superoxide dismutase [Mn], mitochondrial 0 52125000.0 15322000.0 15496000.0 21307000.0 False True 23244594.188243266 12730617.729199398 17095662.110810146 1.0 0.5476807909014103 0.7354682973754324 24.4703919032446 -10.199320323020224 5.425463380246259 1.0000162308244123 0.6415745441383728 0.8292755165825698 0.07666392848866214 1.5051861861294313e-05 2.221194918898098e-06 0.07423288801714942 0.024743176524260644 6.319455747046514e-11 10.199320323020224 -0.3584416866860395 FNGGGHINHSIFWTNLSPNGGGEPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNGGGHINHSIFWTNLSPNGGGEPK 25 0 P04179-4;P04179;F5H3C5;F5H4R2;F5GYZ5;P04179-3 P04179-4 SOD2 Superoxide dismutase [Mn], mitochondrial 0 29454600.0 7037100.0 9320500.0 13097000.0 False True 9638906.040476948 8908689.491228174 10003758.34118192 1.0 0.9242427982820506 1.0378520445341866 23.20043798761172 -6.7269706467279535 1.7342298844276147 0.9542562969542652 1.0377483691292553 0.5451663503949484 0.03185488087761516 0.3419567894462094 2.0133908913113556 0.014564496381236712 0.036266048772865656 1.8751212402414514e-07 6.7269706467279535 0.0834920721749901 FNGGGHINHSIFWTNLSPNGGGEPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNGGGHINHSIFWTNLSPNGGGEPK 25 0 P04179-4;P04179;F5H3C5;F5H4R2;F5GYZ5;P04179-3 P04179-4 SOD2 Superoxide dismutase [Mn], mitochondrial 0 26798700.0 12617000.0 7154900.0 7026800.0 False True 10491594.527871422 7116355.133563537 8496071.391747663 1.0 0.67829109432876 0.8097979167206132 23.322730621691388 -10.067672429829816 4.983090840631211 1.0000057848416761 0.7440445058743218 0.8347360613730019 0.05368743543100526 3.4504307239623084e-06 6.455965058191945e-07 0.051983810683873886 0.017327545276329365 8.557118972437418e-11 10.067672429829816 -0.2559612789673543 FNGGGHINHSIFWTNLSPNGGGEPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNGGGHINHSIFWTNLSPNGGGEPK 25 0 P04179-4;P04179;F5H3C5;F5H4R2;F5GYZ5;P04179-3 P04179-4 SOD2 Superoxide dismutase [Mn], mitochondrial 0 60397000.0 15322000.0 25136000.0 19939000.0 False True 19834631.04177339 23737159.50368018 16310306.591416774 1.0 1.1967532672368717 0.8223145949660423 24.24151822533705 -6.763959347196978 1.5978210989958483 1.1137242187767271 0.820685261041005 0.7068026822042983 0.08280807539921904 0.27632762022055846 1.3912817466149496 0.04087631258011667 0.09784205964402558 1.7220297606864944e-07 6.763959347196978 -0.2930389577357221 FNGLLCHILDYSFGGGAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FNGLLCHILDYSFGGGAGR 19 0 P46531 P46531 NOTCH1 Neurogenic locus notch homolog protein 1;Notch 1 extracellular truncation;Notch 1 intracellular domain 0 64320000.0 26806000.0 13839000.0 23675000.0 False True 40666661.78110222 11369322.325399486 18995625.872878857 1.0 0.27957353339198365 0.4671056103677071 25.277343232845084 -10.889504155824243 11.197158433057787 1.0362904871154974 0.3733395718798454 0.9370615600859513 0.07655964983247666 0.039128888050796014 0.0003861311571918484 0.041819649304626005 0.024709520732721115 1.2897212163181745e-11 10.889504155824243 -0.6629509152356521 FNGLLCHILDYSFGGGAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNGLLCHILDYSFGGGAGR 19 0 P46531 P46531 NOTCH1 Neurogenic locus notch homolog protein 1;Notch 1 extracellular truncation;Notch 1 intracellular domain 0 14732110.0 7508000.0 767410.0 6456700.0 False True 6243234.66079565 763275.8100110405 7806766.117592246 1.0 0.12225646663644181 1.2504361187342166 22.57386226186914 -6.699073063909236 1.8340841286672545 0.4544499106075562 1.247026666059589 0.4131302522547937 0.3705721150301028 0.39750300194618526 2.598934014853646 0.1612250645772466 0.41511742987620215 1.9995254494345047e-07 6.699073063909236 0.7925767554520329 FNGLLCHILDYSFGGGAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNGLLCHILDYSFGGGAGR 19 0 P46531 P46531 NOTCH1 Neurogenic locus notch homolog protein 1;Notch 1 extracellular truncation;Notch 1 intracellular domain 0 50977000.0 26806000.0 11512000.0 12659000.0 False True 34700895.425256275 10871347.080138702 10355191.892308783 1.0 0.3132872206008331 0.2984128151566944 25.048469554937533 FNGQFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNGQFK 6 0 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 7903700.0 2244600.0 1208700.0 4450400.0 False True 2173346.401631923 1691340.21328723 3284706.730861829 1.0 0.778219345069537 1.5113590398637822 21.051486707988612 -6.82556635997171 1.347598396684244 0.881085576293165 1.529360258869276 0.8967140697291149 0.09865984000616432 0.1863463468349973 0.6633758654728071 0.057507336172287024 0.13239167151528533 1.4942856988413263e-07 6.82556635997171 0.6482746825761111 FNHFSLTLNTNHGHILVDYSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FNHFSLTLNTNHGHILVDYSK 21 0 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 0 4346519600.0 1166879600.0 1332175000.0 1847465000.0 False True 1770241663.5256217 1094437962.9192188 1482312732.9773264 1.0 0.6182421222306625 0.8373504948613317 30.721299176425177 -10.192758329680395 5.40417471155966 1.0000118145991055 0.7277963085459525 0.6729703543502101 0.08945061855294673 1.2733614357228896e-05 1.9020795017537221e-06 0.08661394670045024 0.028870062996936847 6.415664875134731e-11 10.192758329680395 -0.27221550605315303 FNHFSLTLNTNHGHILVDYSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNHFSLTLNTNHGHILVDYSK 21 0 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 0 10268800.0 2504000.0 2011200.0 5753600.0 False True 2082186.946008568 2000365.2664080549 6956651.158359337 1.0 0.9607039705261046 3.341031011502034 20.989668173970887 -6.903149414420267 0.9411621205357739 0.9094034553141561 3.6074840972378484 0.9880685309420107 0.1215689781849036 0.10912353264155049 0.164642042784569 0.09627503777785022 0.25468512465917936 1.249828965813929e-07 6.903149414420267 2.698080641923692 up FNHFSLTLNTNHGHILVDYSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNHFSLTLNTNHGHILVDYSK 21 0 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 0 3716297100.0 1166879600.0 1620493500.0 928924000.0 False True 1510548644.8356655 1530311612.19673 759869363.5651352 1.0 1.0130833041548386 0.5030419683358177 30.492425498517626 -6.901012446928707 0.9548341116094089 1.020620589810459 0.44838787320123935 0.9870636245679126 0.027002823481440417 0.11066424387051742 0.17324188473806926 0.02116895781335933 0.055363798079609575 1.2559939662506669e-07 6.901012446928707 -0.5722327166092196 FNILTSNQK(ub)TLTPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNILTSNQKTLTPEK 15 1 A0A494C164;P52630-4;P52630;B4DLC8 A0A494C164 STAT2 Signal transducer and activator of transcription 2 1 24025400.0 2944700.0 3820700.0 17260000.0 True False 3811972.1987149236 3608074.686334777 14118857.102555463 1.0 0.9465112803160307 3.70381953659451 21.862106166819046 -6.90247649294112 0.9454672652720346 0.8930201526084294 4.008265945820675 0.9877589412330305 0.14243544031568442 0.10960565301728123 0.16731238095658596 0.11243946578086193 0.2963600836729844 1.251767025596084e-07 6.90247649294112 3.1152457932122455 up FNK(ub)GVHEDTHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNKGVHEDTHK 11 1 Q01831;Q01831-2 Q01831 XPC DNA repair protein complementing XP-C cells 1 2801400.0 1130300.0 821120.0 849980.0 True False 939894.5307801439 816696.4635804413 1027706.8881365173 1.0 0.8689235194320749 1.0934278841727978 19.842139349889468 -6.748439185796781 1.6555140268786084 0.9227813392998876 1.0938242170724153 0.6422589505660068 0.05507564800727856 0.30278181934620296 1.6322069665823782 0.026285175065804193 0.06392089559572106 1.7846818798293332e-07 6.748439185796781 0.1710428777725277 FNK(ub)YINTDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FNKYINTDAK 10 1 Q8TEL6-3;Q8TEL6 Q8TEL6-3 TRPC4AP Short transient receptor potential channel 4-associated protein 1 13150100.0 1068100.0 9909700.0 2172300.0 True False 1620385.7885695463 8141236.6101605045 1742943.9528470878 1.0 5.024258215290492 1.0756351759822171 20.62790590650501 -6.641812291400794 2.0382789635163996 3.6280909080894297 1.0922323054444247 0.16143375992890518 1.7211009678120803 0.5288302976055298 4.201420421511316 0.687158511448782 1.9054338863345346 2.281327883125895e-07 6.641812291400794 -2.535858602645005 FNK(ub)YINTDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNKYINTDAK 10 1 Q8TEL6-3;Q8TEL6 Q8TEL6-3 TRPC4AP Short transient receptor potential channel 4-associated protein 1 14877100.0 1068100.0 8544100.0 5264900.0 True False 1382676.5053986502 8068613.324132469 4306742.222435935 1.0 5.835503310158686 3.1147865792325913 20.39903222859746 -9.63439346285892 8.849961866279813 0.999994259996601 4.475144944695641 0.6850685156382359 1.1107279542419568 0.0 0.0 1.0754577172342972 0.3584859057447657 2.3206333922608063e-10 9.63439346285892 3.47515068469904 FNLASHLPGFFVRPDLGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNLASHLPGFFVRPDLGPR 19 1 H7BXU7;A0A1W2PNZ9;Q15652-3;Q15652 H7BXU7 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 0 10514500.0 3995000.0 3248700.0 3270800.0 False True 3868180.911752438 4545922.851746698 2414079.358103288 1.0 1.1752094732526912 0.6240864667856537 21.88322383941933 -6.821216937239133 1.3667554842174237 1.0943222464647888 0.611753825346909 0.8871179501520852 0.07724648392787686 0.19191217831218393 0.7041154026099653 0.04441109475421629 0.10232087711324321 1.5093260326456138e-07 6.821216937239133 -0.4825684211178798 FNLASHLPGFFVRPDLGPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNLASHLPGFFVRPDLGPR 19 1 H7BXU7;A0A1W2PNZ9;Q15652-3;Q15652 H7BXU7 JMJD1C Probable JmjC domain-containing histone demethylation protein 2C 0 10380100.0 3995000.0 2804800.0 3580300.0 False True 3322019.508508073 2789689.985690792 4328924.176563175 1.0 0.8397572556530978 1.3031001670749687 21.663629114853606 -6.813319548720914 1.4005532380333368 0.9130048567724866 1.311834689174028 0.8683086227284607 0.06972355428834892 0.20231226603265856 0.7814958509671976 0.039137560221913545 0.09040400344468066 1.5370233006542142e-07 6.813319548720914 0.39882983240154146 FNLILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNLILR 6 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 278411000.0 69179000.0 92092000.0 117140000.0 False True 90694338.93038899 78352232.57180443 105019476.48622365 1.0 0.8639153611554792 1.1579496330727952 26.43450916588106 -6.780872900826168 1.5326148443775225 0.9230324528591871 1.16033682806695 0.7704159749367657 0.05756957792162288 0.24922239030188245 1.1563562567176076 0.02958458936105396 0.06975220994436182 1.6562546064952753e-07 6.780872900826168 0.23730437520776282 FNLILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNLILR 6 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 265961000.0 84383000.0 42538000.0 139040000.0 False True 81704307.85391885 59523645.23273956 102621252.88940975 1.0 0.7285251756757227 1.2560078603552804 26.28390881058301 -6.766793333682638 1.5865402122690297 0.8436555798346396 1.258635885472524 0.7182332461536923 0.1143245976424595 0.2716362737228539 1.348840988604919 0.056813714284359676 0.13565230057521188 1.710829248221246e-07 6.766793333682638 0.41498030563788435 FNLILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FNLILR 6 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 172252000.0 43953000.0 69041000.0 59258000.0 False True 66679914.39471712 56720094.13020491 47545630.32629598 1.0 0.8506323777569021 0.7130427619454607 25.990748916370354 -6.972109326742476 0.20153574688926112 1.0802912152676822 0.4795787506459213 0.9999944954508533 0.00027487077015108085 0.07562401918499963 0.0065196499128047335 0.00441113457473939 0.014550567502474169 1.0663276563785944e-07 6.972109326742476 -0.600712464621761 FNLILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNLILR 6 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 307369000.0 69179000.0 87020000.0 151170000.0 False True 94756345.79218063 83175168.66334161 115466759.44387794 1.0 0.8777794032471574 1.2185649254258848 26.49771922740395 -6.809699940579248 1.4156654568474099 0.9333671130569127 1.224493483499962 0.8590777919716936 0.052918163934493834 0.20720719342853647 0.8184905045647112 0.029392087219585878 0.06800329897488681 1.5498870851977932e-07 6.809699940579248 0.29112637044304923 FNLILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNLILR 6 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 191310000.0 84383000.0 38468000.0 68459000.0 False True 70168203.30073507 38260765.24869986 82773460.38134755 1.0 0.5452721239664269 1.1796434351694514 26.064314086017287 -6.714298542662809 1.7796672643825158 0.7216742910514868 1.1783610907717363 0.4854955203177538 0.19149771122021592 0.3665484681692572 2.265546714701225 0.08554149133011406 0.2162078355959579 1.9306406999460697e-07 6.714298542662809 0.4566867997202495 FNLILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNLILR 6 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 191431000.0 43953000.0 88671000.0 58807000.0 False True 56898024.94315789 83736380.90192659 48104729.41077511 1.0 1.471692224564573 0.8454551710508856 25.761875238462803 -6.70516230052965 1.8121781120591618 1.2913986425107127 0.8471072504820263 0.44227075793517123 0.1989244104438779 0.3848604749298896 2.460501462688949 0.0874517527982765 0.22350426959803474 1.9716857581922166e-07 6.70516230052965 -0.4442913920286864 FNLMAIVSDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNLMAIVSDR 10 0 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;H0Y636;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 6958600.0 1255400.0 2774800.0 2928400.0 False True 1645841.5573108923 2360810.656085685 2625397.259196324 1.0 1.434409433641332 1.5951701107158263 20.650394025688676 -11.718433978430564 0.17240473990855854 5.15732040265902e-21 1.7530503514464377 0.9994982903947961 0.005630902834236415 4.65767092446547 0.10917429291618552 1.8360860230320595 0.12602537978695183 1.912344017584426e-12 11.718433978430564 1.7530503514464377 FNLMAIVSDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNLMAIVSDR 10 0 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;H0Y636;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 19155100.0 10461000.0 4286600.0 4407500.0 False True 10128921.281061891 5998261.734323684 3253043.527834245 1.0 0.5921915639268194 0.32116386706612887 23.27197720110185 -8.293954042254416 0.20286701550887354 1.2819407541163765 1.872125745930939e-08 0.9997512116982998 0.004400711594899025 0.09419253122176797 0.04506761682112725 0.11637498660550576 0.11743836554479951 5.082132196612739e-09 8.293954042254416 -1.281940735395119 down FNLMAIVSDRK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNLMAIVSDRK 11 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;H0Y636;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 5164300.0 1299300.0 1765100.0 2099900.0 False True 1703394.8824390965 1501753.96030591 1882622.491663147 1.0 0.8816240883356089 1.1052178863936788 20.69998148989432 -6.762887582033536 1.6017686596427234 0.9314866626779068 1.1061483237716168 0.7025637619782575 0.04981172557580344 0.27810211287402814 1.4069118844120874 0.024529949539949567 0.05877853894609441 1.7262846862901988e-07 6.762887582033536 0.17466166109370995 FNLMAIVSDRK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FNLMAIVSDRK 11 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;H0Y636;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 10548200.0 0.0 4977200.0 5571000.0 False True 0.0 4088979.772958907 4469889.40814396 0.0 FNLMAIVSDRK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNLMAIVSDRK 11 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;H0Y636;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 5488100.0 1299300.0 1368200.0 2820600.0 False True 1779686.322262249 1307748.3999676413 2154432.3720804537 1.0 0.7348196047859133 1.2105685957859396 20.76319155141721 -6.755415390261069 1.6295037274450856 0.8450914934931625 1.2119354683065562 0.67201883346518 0.11147523572588251 0.29071169727549695 1.5202151208069572 0.05400249588856527 0.13038233038634628 1.7562430141092662e-07 6.755415390261069 0.3668439748133937 FNLMAIVSDRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNLMAIVSDRK 11 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;H0Y636;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 13425400.0 0.0 5975600.0 7449800.0 False True 0.0 5643052.607025431 6094012.841403116 0.0 FNLTYVSHDGDDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNLTYVSHDGDDK 13 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 33334400.0 9096600.0 6561800.0 17676000.0 False True 11925730.691599708 5582805.0176960705 15847057.08016466 1.0 0.46813106568208085 1.328812253938207 23.507574327327205 -6.739555571569022 1.6883715047920091 0.6833690833925151 1.3292605296038955 0.6028740274015847 0.22347182711421335 0.3186467760891587 1.7833588407127334 0.10471733662824899 0.2570876218457415 1.821563974010417e-07 6.739555571569022 0.6458914462113804 FNLTYVSHDGDDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNLTYVSHDGDDK 13 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 15937700.0 4869200.0 1088900.0 9979600.0 False True 4714629.911265332 1523703.4485384857 7365643.378417388 1.0 0.3231862261124008 1.5622951360015795 22.168713096080822 -6.75841516806595 1.618602425830569 0.6060824237340408 1.5664412483634809 0.6843602477030641 0.28460798224813444 0.28560881904475405 1.4744074274787278 0.1387641884759221 0.33397401480081496 1.7441540145884404e-07 6.75841516806595 0.9603588246294401 FNLTYVSHDGDDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNLTYVSHDGDDK 13 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 21122800.0 9096600.0 3866600.0 8159600.0 False True 12459858.84637173 3695760.826863673 6232470.5322369905 1.0 0.29661337840435215 0.5002039436467505 23.570784388850097 -10.196099424326778 5.800043931780511 1.0000130810594503 0.3984086610257897 0.9208984231909934 0.08311550021482565 1.4059428560643252e-05 1.9487526522999577e-06 0.0804779841671221 0.026825412345303324 6.366497541023496e-11 10.196099424326778 -0.6016044200336605 FNLTYVSHDGDDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNLTYVSHDGDDK 13 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 10725200.0 4869200.0 3116600.0 2739400.0 False True 4048955.5421345523 3099810.2572033335 3312195.8744454854 1.0 0.7655826854471109 0.8180371061074537 21.949118371515098 -10.778823058962276 7.011585782321314 1.005856781005822 0.7918098957773135 0.9545529854282329 0.02141442756185728 0.001997932880328665 6.302372177552208e-05 0.021129510252655855 0.006911476776303194 1.664090499015123e-11 10.778823058962276 -0.21404688522850857 FNNFLK(ub)ALQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNNFLKALQEK 11 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 5581400.0 1694800.0 2057100.0 1829500.0 True False 2221899.2124665473 1750188.6985129951 1640200.8898031928 1.0 0.7876994098981193 0.7381977006879593 21.083361945469488 -13.999999999999998 0.20455138100813822 2.2011479686622493 0.7074532654391155 0.9994876855348374 0.002570346894647617 12.624574680977352 0.14338597176452914 6.078925765457737 0.030483020959998358 1.0000000000000041e-14 13.999999999999998 -1.4936947032231338 FNNFLK(ub)ALQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNNFLKALQEK 11 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 4091900.0 1694800.0 2397100.0 0.0 True False 2321413.3602478746 2291188.195850335 0.0 1.0 0.9869798438679132 0.0 21.14657200699238 -7.033692964054693 1.072996560475786 1.0180021608970855 2.2180966501572004e-18 0.9867751555368698 0.053861750415243694 0.08664513503171933 0.19308123616931003 0.04223195457716204 0.07614482822544208 9.253521448594607e-08 7.033692964054693 -1.0180021608970855 down FNNFLK(ub)ALQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNNFLKALQEK 11 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 17830000.0 5291600.0 5795400.0 6743000.0 True False 6850080.513030151 5472880.8954339605 5515843.189022679 1.0 0.7989513240061199 0.8052231179663509 22.707689514341382 -10.496513152467095 6.0947400529430436 1.00016898664404 0.8020872209862354 0.9992473858429748 0.0025604491624059453 5.884286318487308e-06 4.861011074337338e-07 0.002481247083316304 0.0008263814137340788 3.18776903368593e-11 10.496513152467095 -0.19808176565780455 FNNWGGSLSLGHPFGATGCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNNWGGSLSLGHPFGATGCR 20 0 P55084-2;P55084;B5MD38;F5GZQ3 P55084-2 HADHB Trifunctional enzyme subunit beta, mitochondrial;3-ketoacyl-CoA thiolase 0 261369000.0 74798000.0 91505000.0 95066000.0 False True 98060902.3448624 77852810.68369633 85229482.25746402 1.0 0.7939230500847536 0.8691484599818121 26.547174701405893 -10.807052090731277 9.858032363784636 1.0021106732214073 0.831535755793084 0.8699086099988348 0.030710644989917504 0.001439187188901079 2.8168664867317935e-05 0.030039284675627925 0.009911818049769894 1.559365456106526e-11 10.807052090731277 -0.1705749174283233 FNNWGGSLSLGHPFGATGCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNNWGGSLSLGHPFGATGCR 20 0 P55084-2;P55084;B5MD38;F5GZQ3 P55084-2 HADHB Trifunctional enzyme subunit beta, mitochondrial;3-ketoacyl-CoA thiolase 0 180216300.0 113030000.0 30729300.0 36457000.0 False True 109441924.51949406 42999669.74118254 26907818.013443664 1.0 0.392899429811501 0.2458638965970557 26.70559026422992 -13.99999999999992 0.1991759383698145 4.364268632536352 0.14959323119157117 0.9994869134932673 0.007393724158978654 12.514717992708713 0.1415149267679058 16.39657564494043 0.0942030358465348 1.0000000000001841e-14 13.99999999999992 -4.214675401344781 FNNWGGSLSLGHPFGATGCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FNNWGGSLSLGHPFGATGCR 20 0 P55084-2;P55084;B5MD38;F5GZQ3 P55084-2 HADHB Trifunctional enzyme subunit beta, mitochondrial;3-ketoacyl-CoA thiolase 0 252716000.0 64806000.0 64300000.0 123610000.0 False True 98315439.9532236 52825162.62180692 99178429.31981231 1.0 0.5373028147658192 1.0087777603090553 26.55091466668538 -10.87604850156643 11.047977937507207 1.0096947209255531 0.7730402875377985 0.23604168469711717 0.19247884051456907 0.04518179742952504 0.0005069110582319879 0.1832014244076261 0.06212227865085326 1.3303058424771691e-11 10.87604850156643 -0.2366544333877546 FNNWGGSLSLGHPFGATGCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNNWGGSLSLGHPFGATGCR 20 0 P55084-2;P55084;B5MD38;F5GZQ3 P55084-2 HADHB Trifunctional enzyme subunit beta, mitochondrial;3-ketoacyl-CoA thiolase 0 328232000.0 74798000.0 91574000.0 161860000.0 False True 102452841.93994603 87527957.88527763 123632001.61133868 1.0 0.8543243528235478 1.2067210559547685 26.610384762928785 -6.794469035115283 1.478668403434664 0.9190522009283358 1.2109314486070717 0.8154080233186795 0.06211892144574294 0.22875491914046148 0.9879600491578575 0.03306055893920053 0.07715058049673822 1.6052067041022743e-07 6.794469035115283 0.29187924767873585 FNNWGGSLSLGHPFGATGCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNNWGGSLSLGHPFGATGCR 20 0 P55084-2;P55084;B5MD38;F5GZQ3 P55084-2 HADHB Trifunctional enzyme subunit beta, mitochondrial;3-ketoacyl-CoA thiolase 0 193479000.0 113030000.0 14980000.0 65469000.0 False True 93989453.07801455 14899299.766702792 79158265.2055455 1.0 0.15852097526661688 0.8422037006624706 26.485995539664195 -10.684476341146935 9.189260134414884 1.0006298341254407 0.5003623379759987 0.41592133630674866 0.279112303862532 0.0036054355009322633 0.00012379652936568054 0.27054191641078773 0.0900831087150975 2.0678720293279876e-11 10.684476341146935 -0.500267496149442 FNNWGGSLSLGHPFGATGCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNNWGGSLSLGHPFGATGCR 20 0 P55084-2;P55084;B5MD38;F5GZQ3 P55084-2 HADHB Trifunctional enzyme subunit beta, mitochondrial;3-ketoacyl-CoA thiolase 0 310066000.0 64806000.0 136270000.0 108990000.0 False True 83892644.51724091 128686454.70904295 89154938.33183776 1.0 1.5339420452122758 1.0627265220315636 26.32204098877783 -10.273888078101205 4.0039918836781005 0.9996311090392275 1.2983342836514435 0.3483000687890494 0.19237293187452942 181618179.80969635 113502364.79602297 684336.73482839 0.07040128251574342 5.322454063957067e-11 10.273888078101205 0.29870317461221607 FNSLNELVDYHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNSLNELVDYHR 12 0 P62993;P62993-2 P62993 GRB2 Growth factor receptor-bound protein 2 0 11119500.0 1774400.0 5500400.0 3844700.0 False True 2326255.583314046 4679761.760391268 3446887.32496657 1.0 2.0117143593157354 1.4817319944079586 21.14957818226731 -10.158660334107637 4.72130187840721 0.9999203948644402 1.7467231768675608 0.725793423043845 0.21636439446920355 0.00018131597666426943 3.2310883748162636e-05 0.20951609739472432 0.06983130803817783 6.939683531484658e-11 10.158660334107637 0.7468027820031207 FNSLNELVDYHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNSLNELVDYHR 12 0 P62993;P62993-2 P62993 GRB2 Growth factor receptor-bound protein 2 0 4555600.0 2756300.0 1799300.0 0.0 False True 2668802.765222342 2517769.873225544 0.0 1.0 0.9434079977865223 0.0 21.34776125803747 -7.0718037029286185 1.0234223532984723 1.006588037983478 8.394719346208512e-21 0.9887893271392731 0.04856185563759571 0.0844162880399841 0.16924385565292227 0.03939213665392099 0.0700693611002762 8.476104396168092e-08 7.0718037029286185 -1.006588037983478 down FNSSVLSFEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNSSVLSFEIK 11 0 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 0 4998400.0 1793900.0 1243600.0 1960900.0 False True 1736953.626431214 1740175.9652883285 1447281.4642609567 1.0 1.001855166889939 0.8332297663205755 20.728127806498097 -6.90441235504929 0.9329425109116258 1.0061876005665886 0.8138535907924044 0.9886367663392293 0.008427367838123884 0.10823018871830757 0.15966525238384893 0.006714394821851154 0.017890227411170967 1.246199707404646e-07 6.90441235504929 -0.19233400977418424 FNSVAGHFFFPLLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNSVAGHFFFPLLQR 15 0 Q9Y4R8 Q9Y4R8 TELO2 Telomere length regulation protein TEL2 homolog 0 3369970.0 877740.0 1772800.0 719430.0 False True 1150725.640046251 1508305.1503202755 644990.2848598594 1.0 1.3107426286770254 0.5605074419250233 20.134112471493662 -6.79422613885547 1.479454461597977 1.1727250354227508 0.551578667035311 0.8147108953020247 0.13248541773716557 0.229109516218293 0.9905272608604737 0.07047113279461979 0.16449347548226034 1.6061047301521615e-07 6.79422613885547 -0.6211463683874398 FNSVAGHFFFPLLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNSVAGHFFFPLLQR 15 0 Q9Y4R8 Q9Y4R8 TELO2 Telomere length regulation protein TEL2 homolog 0 6781100.0 1874500.0 2856100.0 2050500.0 False True 1814995.0235494226 3996555.624364741 1513412.5363185746 1.0 2.201965059137758 0.8338383944210104 20.79153416189208 -6.674704962670475 1.9211408806880679 1.7640926386289193 0.8392903516439889 0.2999289046002782 0.5100226495341111 0.4503607716769787 3.2089826337631018 0.2134116857064867 0.5666150015245501 2.1149253233790958e-07 6.674704962670475 -0.9248022869849304 FNSVAGHFFFPLLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FNSVAGHFFFPLLQR 15 0 Q9Y4R8 Q9Y4R8 TELO2 Telomere length regulation protein TEL2 homolog 0 35202800.0 9361800.0 10019000.0 15822000.0 False True 14202535.03925698 8231031.1711957045 12694774.76497105 1.0 0.5795466195608358 0.8938386513310225 23.759645126487033 -10.297475038314872 5.783454212235296 1.0000227740859042 0.7366926354459282 0.4834263142825259 0.12830918467659838 3.768136193126327e-05 4.577161101940933e-06 0.12424556853587358 0.04141161128482565 5.041095926766586e-11 10.297475038314872 -0.263330138639976 FNSVAGHFFFPLLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNSVAGHFFFPLLQR 15 0 Q9Y4R8 Q9Y4R8 TELO2 Telomere length regulation protein TEL2 homolog 0 10895740.0 877740.0 3156000.0 6862000.0 False True 1202264.1980316078 3016557.4845036347 5241336.927326122 1.0 2.5090637228010753 4.359555026180964 20.197322533016553 -6.968389178010457 0.29412633602408955 0.6558153762900256 6.270307441604974 0.9999669508461715 0.007898279559051228 0.07682890771004652 0.010891111224570359 0.031630848629943226 0.1670257954106556 1.0755010085664743e-07 6.968389178010457 5.614492065314948 FNSVAGHFFFPLLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNSVAGHFFFPLLQR 15 0 Q9Y4R8 Q9Y4R8 TELO2 Telomere length regulation protein TEL2 homolog 0 9561200.0 1874500.0 3512400.0 4174300.0 False True 1558729.8044301332 3493478.004043185 5047126.830217497 1.0 2.2412338521495005 3.2379741606741854 20.571939437326357 -7.215285131962256 0.16633775516797103 4.4305036210772076e-08 5.265363805009586 0.9999945294963242 0.002141182551719853 0.09603231745969446 0.008122231959027218 0.07495477566511231 0.16827748487405061 6.091368428567252e-08 7.215285131962256 5.26536376070455 FNSVAGHFFFPLLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNSVAGHFFFPLLQR 15 0 Q9Y4R8 Q9Y4R8 TELO2 Telomere length regulation protein TEL2 homolog 0 29468000.0 9361800.0 12039000.0 8067200.0 False True 12119034.64866687 11369019.066868477 6599052.376462079 1.0 0.9381125969566481 0.5445196393747413 23.530771448579483 -6.934615645904294 0.7078847998952028 1.0050847725562186 0.45332157785927435 0.9973700775892684 0.010344606049754257 0.09031123720597826 0.06645300244428244 0.00969805432151301 0.0347541177865189 1.1624769601484345e-07 6.934615645904294 -0.5517631946969443 FNVLHWHIVDDQSFPYQSITFPELSNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FNVLHWHIVDDQSFPYQSITFPELSNK 27 0 P07686;Q5URX0 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 110748000.0 34557000.0 39024000.0 37167000.0 False True 52425495.455105245 32059862.304096323 29820926.159125227 1.0 0.6115318896995623 0.5688248799606002 25.64376525500638 -13.999999999999998 0.31175553127305894 4.793874964509639 0.5595438946930733 0.9996758478470427 0.0034923992014311957 17.395634402285964 0.1777220042127459 42.85306050334987 0.014693802384826135 1.0000000000000041e-14 13.999999999999998 -4.234331069816566 FNVLHWHIVDDQSFPYQSITFPELSNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNVLHWHIVDDQSFPYQSITFPELSNK 27 0 P07686;Q5URX0 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 78795000.0 34557000.0 20096000.0 24142000.0 False True 44734717.720308244 18977639.93419625 19748403.717838574 1.0 0.4242262140302041 0.44145586971868567 25.414891577098828 -9.893851896258859 6.9909564326202505 1.000000010487506 0.4328410419090832 0.9993083208809856 0.007033977480116895 1.148839491214794e-09 1.8871807364158805e-10 0.0068106195110026945 0.0022702064698389176 1.2768741760764817e-10 9.893851896258859 -0.5671589685784229 FNVLQYVVPEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNVLQYVVPEVK 12 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 13525400.0 2858300.0 6943100.0 3724000.0 False True 3747258.979816578 5907216.543991832 3338676.2031304175 1.0 1.5764100041681615 0.8909648949040186 21.837404257689276 -6.683716667406121 1.8888419037499495 1.36347793767428 0.8935021748267713 0.3411768802186784 0.24410008598275498 0.43029928409886076 2.971284813803062 0.10358131819405997 0.2718789063635814 2.0714923442842294e-07 6.683716667406121 -0.46997576284750875 FNVLQYVVPEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNVLQYVVPEVK 12 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 14846800.0 6303500.0 2392900.0 6150400.0 False True 6103398.842861455 3348397.4488086477 4539425.731955019 1.0 0.5486119349262155 0.7437537425993942 22.541181439567872 -10.250445893595195 5.573028203603597 1.000023523000543 0.6461828387627931 0.8142384826450974 0.07966630938064462 2.3285721197260845e-05 3.1316693898108247e-06 0.07714169418655392 0.025712190790414317 5.617642611725707e-11 10.250445893595195 -0.35384068423774984 FNVLQYVVPEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNVLQYVVPEVK 12 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 25220300.0 2858300.0 11355000.0 11007000.0 False True 3915090.752653118 10853298.554036383 8407373.296280766 1.0 2.7721703632748453 2.1474274358987433 21.900614319212167 -10.21070298137246 5.338416627175812 0.9999107318151803 2.4597988995870628 0.8792247852135313 0.2550502320816239 0.00027099576685047895 4.0066578266396226e-05 0.24696612458706538 0.08231710844140293 6.155977426357419e-11 10.21070298137246 1.4598881677718825 FNVLQYVVPEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNVLQYVVPEVK 12 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 11299800.0 6303500.0 2157200.0 2839100.0 False True 5241639.542398162 2145578.7354293237 3432742.683484774 1.0 0.4093335144613312 0.6548986544607417 22.321586715002148 -10.318829082277555 5.766111062804079 1.0000552625538819 0.5321160844610449 0.8287789435522557 0.10025154860228667 7.122914052243847e-05 8.41473410425649e-06 0.09707955673499732 0.03235604818067879 4.799222861389338e-11 10.318829082277555 -0.467939178092837 FNVWDTAGQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNVWDTAGQEK 11 0 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 35606600.0 3139600.0 17812000.0 14655000.0 False True 4116046.0039296458 15154519.030632187 13138641.180686412 1.0 3.68181478442271 3.1920540169237106 21.972827676257285 -10.586045456167133 8.562598179759597 0.9993044675827055 3.43693440067321 0.9705977311836196 0.199943996067736 0.002655066301911562 0.00012835762896589754 0.19361370173504866 0.06453164724537516 2.5939078521536598e-11 10.586045456167133 2.4376299330905047 FNVWDTAGQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNVWDTAGQEK 11 0 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 37813000.0 11142000.0 5341000.0 21330000.0 False True 10788303.308822455 7473689.15294705 15743033.113716254 1.0 0.6927585310690346 1.459268678592112 23.36296465226057 -6.797921195657834 1.464363450460063 0.8300294237237663 1.4693163948276353 0.8260104918844009 0.131381026482662 0.22374542553445428 0.9474235863987365 0.07058826442557278 0.16437612144731562 1.5924976654351724e-07 6.797921195657834 0.639286971103869 FNVWDTAGQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNVWDTAGQEK 11 0 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 42956600.0 3139600.0 20317000.0 19500000.0 False True 4300394.964499775 19419327.760665536 14894501.615106309 1.0 4.515707957286292 3.463519452994906 22.036037737780177 -10.358273355537257 11.956294731106293 0.9999999364754826 3.9896137051405987 0.9149963492235273 0.4295541581226874 7.263651444855334e-07 3.8358249864545415e-08 0.41591402517455683 0.1386380083919429 4.382547627093975e-11 10.358273355537257 2.989613768665116 FNVWDTAGQEK(ub)FGGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FNVWDTAGQEKFGGLR 16 1 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 1 29263900.0 10495000.0 13792000.0 4976900.0 True False 13759046.633724585 11734287.36079492 4461938.129795856 1.0 0.8528416011057911 0.3242912280607632 23.713877173172477 -6.947350684526239 0.5872138217681389 1.0061619006597697 0.1445021969812949 0.998976601496592 0.009281582255950056 0.08456744124865573 0.040502639757078136 0.009650405660560026 0.04424284220981288 1.1288839942089881e-07 6.947350684526239 -0.8616597036784748 down FNVWDTAGQEK(ub)FGGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNVWDTAGQEKFGGLR 16 1 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 1 52513800.0 25740000.0 17611000.0 9162800.0 True False 24922897.789363634 24643164.140151765 6762787.8018921325 1.0 0.9887760383412859 0.27134837445661286 24.570968484712054 -6.910300682915259 0.8936737171254704 1.0220028769787246 0.17803080865560028 0.991034651491674 0.03227592342637829 0.10422023671912563 0.13768770294248292 0.026463972449664076 0.07320666064358568 1.2294172914854405e-07 6.910300682915259 -0.8439720683231243 down FNVWDTAGQEK(ub)FGGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FNVWDTAGQEKFGGLR 16 1 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 1 62590200.0 28255200.0 17952000.0 16383000.0 True False 42865204.13181371 14748325.340383792 13144892.869076008 1.0 0.3440628742845033 0.30665648596130507 25.353303678000643 -13.711561583448018 0.4101863681242976 9.999860632694425 0.3049399609438633 0.9998469852113807 0.003938513872007796 22.111984792925085 0.21195225550822536 176.19655405278667 0.009314269858358232 1.942846174512791e-14 13.711561583448018 -9.69492067175056 FNVWDTAGQEK(ub)FGGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FNVWDTAGQEKFGGLR 16 1 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 1 29775600.0 10495000.0 11643000.0 7637600.0 True False 14375285.116710797 11128573.761747733 5833756.1813095305 1.0 0.7741462984140142 0.4058184678735854 23.77708723469537 -6.963830517757066 0.37758887290804855 1.0259965574701193 0.14099294836465717 0.9998869663568688 0.0026035660736261875 0.07836011766128541 0.01627340373842465 0.004806010262656094 0.031159848304307212 1.0868496810064794e-07 6.963830517757066 -0.8850036091054622 down FNVWDTAGQEK(ub)FGGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FNVWDTAGQEKFGGLR 16 1 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 1 57965200.0 25740000.0 26276000.0 5949200.0 True False 21403950.475343622 26134445.972622328 7193150.214007112 1.0 1.2210103925781375 0.33606647624667674 24.35137376014633 -6.840569074001831 1.2797216289068845 1.117564602638751 0.3066248494348586 0.9254361194902837 0.10268795500009835 0.16813178309871188 0.5346145263075571 0.06291427261426286 0.14496735153911633 1.4435469916623894e-07 6.840569074001831 -0.8109397532038922 down FNVWDTAGQEK(ub)FGGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNVWDTAGQEKFGGLR 16 1 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 1 56955200.0 28255200.0 18228000.0 10472000.0 True False 36576913.39325899 17213595.776300237 8566203.45179378 1.0 0.47061367894078915 0.2341970017998431 25.124430000093092 -10.26995016334315 0.18423611584375477 1.7329773293579618 1.4600329984420806e-21 0.9995044214437627 0.007127559709431892 1.9020464040728766 0.09009112701094195 0.8175066326848514 0.15841049851332545 5.3709342599288485e-11 10.26995016334315 -1.7329773293579618 FNYQGTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 FNYQGTKR 8 1 K7EMW4;Q969V3-2;Q969V3;K7ENM2;A0A0C4DGP7 K7EMW4 NCLN Nicalin 1 7165500.0 891500.0 1800000.0 4474000.0 True False 863199.8204824287 2518749.386875996 3302125.1828770074 1.0 2.917921583287989 3.82544702225668 19.719335039228987 -9.067902204181916 0.26861541858433785 1.466387470448851e-13 4.350600054769887 0.9989624313976204 0.037938878958111495 0.5183459586392009 0.09405944873214546 0.8491417459150199 0.3526202383529371 8.552592812179763e-10 9.067902204181916 4.350600054769741 FNYQGTK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 FNYQGTKR 8 1 K7EMW4;Q969V3-2;Q969V3;K7ENM2;A0A0C4DGP7 K7EMW4 NCLN Nicalin 1 13380300.0 1062600.0 3552300.0 8765400.0 True False 1612041.8864656882 2918364.3107534177 7032914.847988697 1.0 1.8103526560043477 4.362737039921444 20.620457799921592 -6.9503508383073225 0.5549780240479913 0.9656987439354394 5.328326769855879 0.999228533003939 0.03979977523109199 0.08334516114349981 0.035381611711366424 0.042926611332517704 0.21194848353245094 1.121112414475188e-07 6.9503508383073225 4.36262802592044 FNYQGTK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FNYQGTKR 8 1 K7EMW4;Q969V3-2;Q969V3;K7ENM2;A0A0C4DGP7 K7EMW4 NCLN Nicalin 1 11855900.0 1062600.0 2215900.0 8577400.0 True False 1375556.6469774432 2092583.2170673527 7016401.211556163 1.0 1.5212628441478262 5.10077227788004 20.39158412201404 -6.933050528903045 0.7213114470847409 0.9512472937881131 5.896175790408946 0.9971045830048865 0.09807915057935358 0.09108448936855107 0.07014500072442899 0.09103513633375492 0.3186253807841665 1.1666738700440692e-07 6.933050528903045 4.9449284966208324 up FPDEDEILEK(ub)DEALEDEDNKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FPDEDEILEKDEALEDEDNKK 21 2 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 11971400.0 4537200.0 5707900.0 1726300.0 True False 5948313.138307306 4856303.569219938 1547679.035838892 1.0 0.8164169330537097 0.2601878885413404 22.50404916681399 -6.951227944018803 0.5451973058627565 1.007920692864598 0.042767675170726355 0.9992941503701888 0.008356628226682365 0.08299639510792481 0.03395063661208191 0.009127113253029003 0.0461036384080833 1.1188504889038016e-07 6.951227944018803 -0.9651530176938717 down FPDEDEILEK(ub)DEALEDEDNKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FPDEDEILEKDEALEDEDNKK 21 2 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 14519900.0 4537200.0 7224500.0 2758200.0 True False 6214725.453219649 6905297.701773294 2106769.9669121145 1.0 1.1111187056856842 0.33899646617867324 22.56725922833688 -6.870393481095785 1.1320854014348367 1.0629899361366506 0.29345207741699775 0.965070581658312 0.06369790952920712 0.13647432880353647 0.3266740111913486 0.04365823723646176 0.10342828964657236 1.3477412437425914e-07 6.870393481095785 -0.7695378587196529 down FPDEDEILEK(ub)DEALEDEDNKKDDGISFSNQTGPAWAGSER ddPTM_RPMI8226_Bortezomib_2h_R1 1 FPDEDEILEKDEALEDEDNKKDDGISFSNQTGPAWAGSER 40 3 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 59096500.0 38708000.0 8985500.0 11403000.0 True False 37479235.72768793 12573457.008763472 8416212.217332706 1.0 0.3354779457115445 0.2245566659491724 25.159588198235408 -13.999999999999998 0.2519010192873541 5.666083232615275 0.1807565763458721 0.9995462942166959 0.0072934713405835416 14.074183726451905 0.15881570319741192 33.26764477583462 0.050654250456494264 1.0000000000000041e-14 13.999999999999998 -5.485326656269403 FPDEDEILEK(ub)DEALEDEDNKKDDGISFSNQTGPAWAGSER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FPDEDEILEKDEALEDEDNKKDDGISFSNQTGPAWAGSER 40 3 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 67940200.0 38708000.0 20396000.0 8836200.0 True False 32187417.05515155 20286122.699710995 10683808.566027312 1.0 0.6302500963327292 0.3319250049707665 24.939993473669684 -7.683605317769139 0.23299769161188205 1.1682616653552762 2.946690924539579e-14 0.9998386043693315 0.0034715277396968154 0.12972885266736392 0.02956643647390446 0.04163892718598927 0.07943002944407423 2.0720235264713577e-08 7.683605317769139 -1.1682616653552467 down FPEHELTFDPQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FPEHELTFDPQR 12 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 4560870.0 1303700.0 816370.0 2440800.0 False True 1262314.7571093 1142350.7983133083 1801481.2575695566 1.0 0.904965098347809 1.4271252454458725 20.267640259281265 -6.859784531776957 1.1869411247486332 0.9484715116475579 1.452291659197407 0.953362358847384 0.04904126043102073 0.14702777317916718 0.39374023726297863 0.032229605155180405 0.07520950124637708 1.3810692899750794e-07 6.859784531776957 0.5038201475498492 FPFLGVHFTPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FPFLGVHFTPR 11 0 C9JVN9;Q9H9P8-2;Q9H9P8 C9JVN9 L2HGDH L-2-hydroxyglutarate dehydrogenase, mitochondrial 0 13089700.0 3441600.0 5437200.0 4210900.0 False True 4511970.928501814 4625990.954039604 3775196.4618050107 1.0 1.025270558552923 0.8367067345131484 22.10532634152866 -6.8731047035479715 1.1174806714533037 1.0146005328629981 0.8249888473739528 0.9676877055983738 0.015022715580085362 0.13391590152393248 0.3106582874469414 0.010411808508896883 0.024793366259647696 1.3393537452729063e-07 6.8731047035479715 -0.18961168548904528 FPFLGVHFTPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FPFLGVHFTPR 11 0 C9JVN9;Q9H9P8-2;Q9H9P8 C9JVN9 L2HGDH L-2-hydroxyglutarate dehydrogenase, mitochondrial 0 11254600.0 4302300.0 3574100.0 3378200.0 False True 4165725.8414599607 5001256.76868527 2493348.0761723532 1.0 1.200572711461127 0.598538687149539 21.990136463868062 -6.816892855140465 1.3853286940171297 1.1084575159814245 0.5862573861764442 0.8770764906614458 0.0877558958311409 0.197547581244733 0.7457845529438837 0.04979069593260319 0.1148618817694479 1.5244287994757115e-07 6.816892855140465 -0.5222001298049803 FPFLGVHFTPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FPFLGVHFTPR 11 0 C9JVN9;Q9H9P8-2;Q9H9P8 C9JVN9 L2HGDH L-2-hydroxyglutarate dehydrogenase, mitochondrial 0 18444500.0 3441600.0 5547300.0 9455600.0 False True 4714052.5257429145 5302201.943532007 7222382.024194823 1.0 1.1247651388221225 1.5320962133438694 22.16853640305155 -6.949535111138568 0.5639225311026965 0.9947780218064505 1.6816819268433136 0.9991643065789141 0.006568209018585738 0.08367292582501912 0.03673882397139663 0.007007850240884453 0.03388987493158779 1.1232201577149808e-07 6.949535111138568 0.6869039050368632 FPFLGVHFTPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FPFLGVHFTPR 11 0 C9JVN9;Q9H9P8-2;Q9H9P8 C9JVN9 L2HGDH L-2-hydroxyglutarate dehydrogenase, mitochondrial 0 15158800.0 4302300.0 4570000.0 6286500.0 False True 3577553.074206335 4545380.502926028 7600978.084508116 1.0 1.270527762592146 2.1246304182906806 21.770541739302338 -6.950297462145678 0.5555701561056734 0.9885595556121475 2.447108264580513 0.9992244083034645 0.013347960376691639 0.0833665549054179 0.03546999670899592 0.014386040118697062 0.07093270538719608 1.1212502111947063e-07 6.950297462145678 1.4585487089683657 up FPGYDSESK(ub)EFNAEVHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FPGYDSESKEFNAEVHR 17 1 P46777;A0A2R8Y6J3 P46777 RPL5 60S ribosomal protein L5 1 15803600.0 1484500.0 3433100.0 10886000.0 True False 1921714.513869765 3242044.9670625557 8904859.699792514 1.0 1.687058584229577 4.633809879418956 20.873962597414987 -6.943275360884008 0.6283527360684023 0.9678537730115524 5.511380992491701 0.9985622166193773 0.05976694417938239 0.0863036400575141 0.04803992785234226 0.05973931626820044 0.2501929650471114 1.1395270506043043e-07 6.943275360884008 4.543527219480149 FPHGIPFLADYVHSLGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FPHGIPFLADYVHSLGLK 18 0 P17050 P17050 NAGA Alpha-N-acetylgalactosaminidase 0 5804300.0 2538200.0 1247600.0 2018500.0 False True 2110625.7613254543 1240878.9311707893 2440559.017510485 1.0 0.5879199211477113 1.1563201123717146 21.009239363952666 -6.712254084480971 1.7872563097097522 0.7472472424700158 1.15507065235829 0.47577233027396504 0.17358825680421472 0.37055765144191344 2.3087390766239824 0.07725309789775249 0.195718256188135 1.9397506922040194e-07 6.712254084480971 0.40782340988827426 FPLFGGWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FPLFGGWK 8 0 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 16232900.0 4567700.0 4605600.0 7059600.0 False True 5988298.933669729 3918462.4324881933 6329140.312464951 1.0 0.6543531770694176 1.0569178964795514 22.513714811321417 -6.6794452043964245 1.903755476728329 0.7811953184819439 1.0553819646731164 0.321591107481615 0.1465114006375192 0.43978109906874 3.0811250751781767 0.06176212284444969 0.16301546389008914 2.0919668371296468e-07 6.6794452043964245 0.2741866461911725 FPLFGGWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FPLFGGWK 8 0 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 7444100.0 2831600.0 1226200.0 3386300.0 False True 2741712.407939476 1715828.054548527 2499326.443177561 1.0 0.6258234997878758 0.9115932203319314 21.38664581680906 -9.85872490706196 5.840165580122271 1.0000000499947503 0.768708360059532 0.46621861527891695 0.1166649998797643 7.589226917967603e-08 1.4843236031406619e-08 0.11296042481127501 0.03765346680144237 1.384443041985476e-10 9.85872490706196 -0.23129168993521831 FPLFGGWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FPLFGGWK 8 0 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 13044200.0 4567700.0 3735700.0 4740800.0 False True 6256502.12745116 3570644.4216920882 3621120.6798408153 1.0 0.570709375455249 0.5787771834924678 22.57692487284431 -10.04238046231737 5.094619005306079 1.00000562269452 0.5747432794718949 0.9997301303026991 0.0032936688458153193 2.1034976880925907e-07 3.954111226329437e-08 0.0031891233286475106 0.0010630270480003424 9.070255851083037e-11 10.04238046231737 -0.4252623432226251 FPLFGGWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FPLFGGWK 8 0 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 5699700.0 2831600.0 1199500.0 1668600.0 False True 2354600.8611493027 1193038.0554178902 2017496.545265292 1.0 0.5066837760500763 0.8568316518327158 21.167051092243337 -9.980337548541467 6.33403603827952 1.000000110708042 0.6817577139413875 0.5241304727499214 0.1429472716978528 2.2359595999720934e-07 3.614301412199859e-08 0.13840814810367047 0.04613603355595875 1.0463150000895619e-10 9.980337548541467 -0.31824239676665456 FPQATDQTLVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FPQATDQTLVDK 12 0 F5H2J1;Q8WXR4-6;Q8WXR4-3;Q8WXR4-5;Q8WXR4-2;Q8WXR4-4;Q8WXR4;Q8WXR4-7 F5H2J1 MYO3B Myosin-IIIb 0 5889300.0 2283400.0 1774200.0 1831700.0 False True 2993559.512477057 1509496.2757774326 1642173.254907085 1.0 0.504247959489665 0.5485687684051582 21.513430520875087 -10.000281315029198 7.4174839367639125 1.0000000181974285 0.526408364859819 0.9934743276337155 0.018093894471725915 5.45596921208949e-09 7.039004178226102e-10 0.01751933877243087 0.00583977932975238 9.993524579532346e-11 10.000281315029198 -0.47359165333760944 FPQATDQTLVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FPQATDQTLVDK 12 0 F5H2J1;Q8WXR4-6;Q8WXR4-3;Q8WXR4-5;Q8WXR4-2;Q8WXR4-4;Q8WXR4;Q8WXR4-7 F5H2J1 MYO3B Myosin-IIIb 0 9836100.0 4246800.0 1678300.0 3911000.0 False True 4111987.658580795 2348453.9422188816 2886591.7725149654 1.0 0.5711237817842633 0.7019942694845633 21.971404503863017 -10.707327427984007 10.115578097394545 1.0003979986774685 0.6365590256344148 0.9113716900436256 0.05342765287581951 0.00048004125422328056 1.388888792973763e-05 0.051783301480710066 0.01724370081791664 1.9618805969198713e-11 10.707327427984007 -0.3638389730430537 FPQATDQTLVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FPQATDQTLVDK 12 0 F5H2J1;Q8WXR4-6;Q8WXR4-3;Q8WXR4-5;Q8WXR4-2;Q8WXR4-4;Q8WXR4;Q8WXR4-7 F5H2J1 MYO3B Myosin-IIIb 0 7564500.0 2283400.0 2865200.0 2415900.0 False True 3127634.6865647864 2738605.9900506414 1845314.1770223246 1.0 0.8756156854938095 0.5900031052057142 21.576640582397978 -6.957257451628987 0.4725087116415666 1.0073628102553684 0.4464978115528971 0.9996545439746184 0.0031901777218338086 0.08069586219690952 0.024865200550518655 0.003967913207320652 0.023569190298376803 1.1034243113249714e-07 6.957257451628987 -0.5608649987024714 FPQATDQTLVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FPQATDQTLVDK 12 0 F5H2J1;Q8WXR4-6;Q8WXR4-3;Q8WXR4-5;Q8WXR4-2;Q8WXR4-4;Q8WXR4;Q8WXR4-7 F5H2J1 MYO3B Myosin-IIIb 0 7550300.0 4246800.0 2180700.0 1122800.0 False True 3531402.3651394504 2168952.1362649426 1357572.288759362 1.0 0.6141900333068655 0.38442866272072435 21.751809779297293 -9.055059318306352 0.15057468265494434 1.5090360802310678 3.612537688904822e-12 0.9998369084103196 0.003243547567097291 0.5159072269806254 0.04977961488849542 0.28971103770673307 0.1718193530464408 8.809285427708974e-10 9.055059318306352 -1.5090360802274554 FPQLDSTSFANSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FPQLDSTSFANSR 13 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 10706000.0 0.0 5508700.0 5197300.0 False True 0.0 4686823.432744414 4659533.252021946 0.0 FPQLDSTSFANSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FPQLDSTSFANSR 13 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 10531600.0 0.0 4840200.0 5691400.0 False True 0.0 4626343.959599012 4347208.538062364 0.0 FPSPEDIPSDK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FPSPEDIPSDKQR 13 1 Q13568-5;Q13568-4;Q13568;Q13568-3;Q13568-2 Q13568-5 IRF5 Interferon regulatory factor 5 1 3520700.0 1390800.0 2129900.0 0.0 True False 1823352.2685263574 1812127.2222851731 0.0 1.0 0.9938437314418369 0.0 20.798161883833224 -7.028263434249783 1.080535504684998 1.020050829005087 4.920931976464886e-18 0.9863360565568065 0.05493499643197657 0.08726974670402686 0.19756185197598145 0.04280742077433068 0.07736922164760889 9.369934732211885e-08 7.028263434249783 -1.020050829005087 down FPSPEDIPSDK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FPSPEDIPSDKQR 13 1 Q13568-5;Q13568-4;Q13568;Q13568-3;Q13568-2 Q13568-5 IRF5 Interferon regulatory factor 5 1 7237600.0 1390800.0 2607600.0 3239200.0 True False 1905016.344956774 2492387.609819924 2474167.673418066 1.0 1.3083287271619066 1.2987645381458428 20.861371945356115 -10.004195089908306 4.7581936502091144 0.9999944538345871 1.3035466326643619 0.9992559802928729 0.003904563851523393 496649.60133557284 1044215.4081275346 16.90180243318859 0.001336636213774347 9.903869521256943e-11 10.004195089908306 0.3035521788297748 FPTLWSGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FPTLWSGAR 9 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 9977600.0 2565900.0 2996000.0 4415700.0 False True 3363919.7482109456 2549008.47831653 3958805.722385329 1.0 0.757749491399783 1.1768430933855558 21.681711857485862 -6.749983784253573 1.650047328857517 0.8575523315101518 1.1776684710084828 0.6488707585068165 0.10179462269740848 0.3000595074272977 1.607387449566173 0.04873575759067612 0.11831264448019 1.7783458089169704e-07 6.749983784253573 0.32011613949833106 FPTLWSGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FPTLWSGAR 9 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 9794100.0 3065900.0 1690700.0 5037500.0 False True 2968574.682688815 2365805.3268840252 3718027.6282393653 1.0 0.796949910231389 1.2524622169423496 21.501338977862616 -6.785502422784485 1.5140364827183066 0.8858490301355277 1.2567390394323164 0.7864973402807035 0.0860946557449489 0.2421191790614866 1.096430511359281 0.04476932022779922 0.10517931014935085 1.6386929195363024e-07 6.785502422784485 0.3708900092967886 FPTLWSGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FPTLWSGAR 9 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 12247600.0 2565900.0 3149300.0 6532400.0 False True 3514582.5708402283 3010153.512657572 4989581.659001052 1.0 0.8564753998475378 1.4196797367626497 21.744921919008753 -6.839144750693556 1.2865395278004719 0.9236409966763464 1.437871754599544 0.9229421080313723 0.06633444300228358 0.1698034826624731 0.5463521335818395 0.04043767762809326 0.09313109270706868 1.4482890572052985e-07 6.839144750693556 0.5142307579231977 FPTLWSGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FPTLWSGAR 9 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 5633200.0 3065900.0 1005100.0 1562200.0 False True 2549431.692399228 999685.3268032708 1888848.797203308 1.0 0.3921208517897114 0.7408901375293345 21.281744253296893 -10.259109016651175 5.894789927517053 1.0000186031672682 0.5665054946595777 0.6731834888960353 0.1423844646695122 3.481263714667136e-05 4.375590661651993e-06 0.13786907175262378 0.045954388368638695 5.50669449945669e-11 10.259109016651175 -0.43351310850769054 FPVVAMGVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FPVVAMGVLK 10 0 X6RLT1;H0UI80;Q8IXH7-4;Q8IXH7 X6RLT1 NELFCD;TH1L Negative elongation factor C/D 0 2752740.0 652040.0 1068900.0 1031800.0 False True 893116.8087184465 1021672.4636203841 788110.0905880356 1.0 1.1439404718923665 0.8824266690478176 19.768489348930256 -6.757279725086785 1.622765272948333 1.0838910113978573 0.8815994040351081 0.679745376858562 0.060520327122890266 0.2875104545592918 1.4915751287417498 0.029435108631400406 0.07092695820517873 1.748719991331553e-07 6.757279725086785 -0.2022916073627492 FQALQDNCK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQALQDNCKK 10 1 Q8N3C0;Q8N3C0-4 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 1 12455500.0 1312300.0 3724200.0 7419000.0 True False 1990855.0419809157 3059587.412692592 5952631.398136789 1.0 1.5368207871369075 2.989987353480983 20.924956748781046 -6.953735543359619 0.5162078832868506 0.9745631795092916 3.6166762164556183 0.9994627650411397 0.019484383149528346 0.08201952050858921 0.030016165588721 0.022208987197504602 0.11999026883253242 1.1124089045951149e-07 6.953735543359619 2.6421130369463266 FQALQDNCK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQALQDNCKK 10 1 Q8N3C0;Q8N3C0-4 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 1 10909320.0 1312300.0 4227720.0 5369300.0 True False 1698798.2193002987 3992443.665535444 4392142.493670392 1.0 2.3501576703911615 2.585440956889764 20.696083070873495 -10.433252246279876 0.3679342055241365 1.0279373472196475e-20 2.6207586074309557 0.9991494240108691 0.02037332223605771 1.897187409031038 0.17367405708411893 1.8757254294224814 0.0658206616568908 3.6876335177130915e-11 10.433252246279876 2.6207586074309557 FQAVVALAVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQAVVALAVGR 11 0 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 0 12959400.0 2601300.0 4662700.0 5695400.0 False True 3946362.280503662 3830604.7551586237 4569701.693617504 1.0 0.9706672836609759 1.1579529117722784 21.912091972495354 -6.86686372762578 1.1504764780704877 0.9836851779287877 1.1682905478414485 0.9614559178112865 0.01614783440091975 0.13990187782210414 0.34804265916521643 0.010911846942041718 0.025704137455673404 1.3587397233403016e-07 6.86686372762578 0.18460536991266074 FQDLGAAYEVLSDSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQDLGAAYEVLSDSEK 16 0 Q9UBS4 Q9UBS4 DNAJB11 DnaJ homolog subfamily B member 11 0 8914630.0 747030.0 4347600.0 3820000.0 False True 979363.5642488095 3698955.02681207 3424743.044027437 1.0 3.7768967131723334 3.496906735196219 19.901484998178656 -9.914498982640053 6.565927920422669 0.999999803314486 3.636901724184357 0.9916150312143448 0.1143054298560527 3.2902445705070015e-07 5.4253817737817844e-08 0.11067576314904967 0.03689191885108828 1.217589845116563e-10 9.914498982640053 2.636901920869871 FQDLGAAYEVLSDSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQDLGAAYEVLSDSEK 16 0 Q9UBS4 Q9UBS4 DNAJB11 DnaJ homolog subfamily B member 11 0 7101530.0 747030.0 3459900.0 2894600.0 False True 1023227.1787266742 3307030.177640728 2210955.0961582945 1.0 3.2319608454459425 2.1607665845131816 19.964695059701548 -10.48468150244764 6.207949520864967 0.9989273766701353 2.6963637149795514 0.7697867888977598 0.437313225780501 0.006494744625977977 0.000539125088182939 0.42359418483738054 0.14114223671034373 3.275808440247198e-11 10.48468150244764 1.6974363383094162 FQDTDGK(ub)HLLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQDTDGKHLLPK 12 1 P52209-2;P52209;K7EPF6;K7ELN9 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 14038100.0 4572300.0 5517200.0 3948600.0 True False 5994329.578216178 4694055.265877165 3540036.7496457486 1.0 0.7830826124302035 0.5905642496719725 22.515166977130693 -6.9725335206150305 0.18806797174415732 1.1338185843452566 0.23457946868958268 0.9999959911685012 0.00033481998380548427 0.07548888971827654 0.005986159694619743 0.006910080677682186 0.02110028345823215 1.0652866373375587e-07 6.9725335206150305 -0.8992391156556739 FQDTDGK(ub)HLLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQDTDGKHLLPK 12 1 P52209-2;P52209;K7EPF6;K7ELN9 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 14603200.0 3887100.0 5577500.0 5138600.0 True False 3763706.13819097 7804624.836278257 3792646.5053043724 1.0 2.073654145599571 1.0076893269694305 21.843722559365965 -6.644533805454293 2.028270491257592 1.6996905770296447 1.01216883957673 0.17213175646657397 0.45886952020023525 0.5220390897347728 4.110003045614372 0.1838916730060356 0.5081049286205632 2.2670766011812852e-07 6.644533805454293 -0.6875217374529146 FQDTDGK(ub)HLLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQDTDGKHLLPK 12 1 P52209-2;P52209;K7EPF6;K7ELN9 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 50480000.0 12246000.0 15665000.0 22569000.0 True False 18578077.30252099 12869458.358796371 18108227.257655885 1.0 0.6927228339743222 0.9747094364387563 24.14709786508976 -10.411440652165018 8.120361068192462 1.0000027639850884 0.8337161354991008 0.3167724360889801 0.11512054838981815 5.760572391623398e-06 4.1768937428636557e-07 0.11146684337607206 0.03715499722666924 3.8775673318155504e-11 10.411440652165018 -0.16628662848598752 FQDTDGK(ub)HLLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQDTDGKHLLPK 12 1 P52209-2;P52209;K7EPF6;K7ELN9 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 12465100.0 4572300.0 4386100.0 3506700.0 True False 6262802.871761472 4192307.599106903 2678489.6827535024 1.0 0.6693979812153623 0.42768225946095473 22.578377038653585 -7.771121880979726 0.16861044434718842 1.2852202812985043 1.6926795115899413e-10 0.9999491491132643 0.0016728123113005844 0.12976679510477948 0.02254037184778485 0.061280197957181086 0.09123085456995514 1.693862365954968e-08 7.771121880979726 -1.2852202811292364 down FQDTDGK(ub)HLLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQDTDGKHLLPK 12 1 P52209-2;P52209;K7EPF6;K7ELN9 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 14830600.0 3887100.0 7100100.0 3843400.0 True False 3232295.8777275975 7061850.352040486 4647037.170126227 1.0 2.184778442066752 1.4376892914250274 21.62412783480024 -10.069381338398282 4.733036538803254 0.9999706080654097 1.8112338667564372 0.6112158316237799 0.30499786863032924 211661261.52217656 3.078026041659117 73703.56791078746 0.1044088828913263 8.523513661965523e-11 10.069381338398282 0.8112632586910274 FQDTDGK(ub)HLLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQDTDGKHLLPK 12 1 P52209-2;P52209;K7EPF6;K7ELN9 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 46002000.0 12246000.0 13608000.0 20148000.0 True False 15852688.404748503 12850702.83760663 16481270.735937877 1.0 0.8106323993447911 1.039651465741362 23.918224187182208 -6.687068761505234 1.8764316766331104 0.8809590476128561 1.0388425835790929 0.3569695471903137 0.08013662044879657 0.42297237011437144 2.8850078877326695 0.03419141449299819 0.08938034573254772 2.0555651142033167e-07 6.687068761505234 0.15788353596623672 FQEAEERPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQEAEERPK 9 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 5364500.0 1733600.0 1051000.0 2579900.0 False True 1678567.816924662 1470669.780892596 1904146.7946590062 1.0 0.8761455843869567 1.1343877652483723 20.6787993948103 -6.776293365749789 1.550354588916718 0.9295326642673191 1.1361990985657182 0.7540398188341961 0.05230031997151034 0.2563772749786135 1.2168881113813246 0.02657750677639868 0.06290775296069749 1.6738118348318228e-07 6.776293365749789 0.20666643429839915 FQEYHIQQNEALAAK(ub)AGLLGQPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQEYHIQQNEALAAKAGLLGQPR 23 1 Q9Y5J7 Q9Y5J7 TIMM9 Mitochondrial import inner membrane translocase subunit Tim9 1 50177000.0 11083000.0 21167000.0 17927000.0 True False 14347161.978591176 19989037.84271157 14664469.946553402 1.0 1.3932398527694327 1.0221164275161674 23.77426204889343 -10.633366451945545 5.818146711329772 0.9984715084915613 1.2076781401428318 0.2945455899686843 0.15151050391073884 0.0030247909316751245 0.00019060854592265405 0.14771736179542522 0.04889980486848209 2.326127673562267e-11 10.633366451945545 0.2092066316512705 FQFVSGADEK(ub)VLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQFVSGADEKVLR 13 1 Q6IA86-4;Q6IA86-7;Q6IA86-2;Q6IA86-3;Q6IA86-5;Q6IA86;Q6IA86-6 Q6IA86-4 ELP2 Elongator complex protein 2 1 24019900.0 7625200.0 7354200.0 9040500.0 True False 7383142.1998234475 10290770.411646359 6672521.840813488 1.0 1.3938198849661112 0.9037509586329039 22.815803514514094 -6.69276833755181 1.8563819920369988 1.2462548021661837 0.9053771574294763 0.383483113434095 0.16646548578040202 0.41075657526519566 2.7465170912909946 0.07167630768299323 0.1860149451381016 2.028764619635628e-07 6.69276833755181 -0.34087764473670734 FQFVSGADEK(ub)VLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQFVSGADEKVLR 13 1 Q6IA86-4;Q6IA86-7;Q6IA86-2;Q6IA86-3;Q6IA86-5;Q6IA86;Q6IA86-6 Q6IA86-4 ELP2 Elongator complex protein 2 1 45715400.0 16825000.0 8268400.0 20622000.0 True False 21780294.170332626 7808256.271492249 16869007.59958856 1.0 0.35850095551638744 0.7745077944156592 24.376520103813373 -10.1044967086851 5.547579682851488 1.0000046677636103 0.5665043749660826 0.5914691463241619 0.16983408080227752 9.804822775794735e-06 1.5826439051302853e-06 0.16444291266643746 0.05481371388041785 7.86146148959792e-11 10.1044967086851 -0.43350029279752766 FQGVSLPVHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQGVSLPVHLR 11 0 C9JG87;Q9NYK5;Q9NYK5-2 C9JG87 MRPL39 39S ribosomal protein L39, mitochondrial 0 6478000.0 2779600.0 3698400.0 0.0 False True 3644082.51768469 3146613.13625029 0.0 1.0 0.8634856979719348 0.0 21.797124197648166 -7.160596851866077 0.9276996750702952 0.9932635702297475 4.757809539689034e-17 0.9896406977377132 0.04506333014058712 0.08880495523980873 0.14474410795117085 0.037760781866258614 0.06630031035298412 6.908808391206222e-08 7.160596851866077 -0.9932635702297475 down FQGVSLPVHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQGVSLPVHLR 11 0 C9JG87;Q9NYK5;Q9NYK5-2 C9JG87 MRPL39 39S ribosomal protein L39, mitochondrial 0 10028400.0 2779600.0 2962100.0 4286700.0 False True 3807293.235865583 2831224.6276451913 3274269.7473577517 1.0 0.7436318802487816 0.8599993603101996 21.860334259171058 -10.04151822494741 4.523427200632442 1.0000088738301476 0.8018156202819371 0.7945497093242291 0.04750682484806635 32877377.762902748 0.6597289465352695 3133.4916870367283 0.016262849745886907 9.088281597530996e-11 10.04151822494741 -0.1981932535482105 FQHGVIAAVDSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQHGVIAAVDSR 12 0 X5D2R7;P28062-2;P28062;Q5JNW7;A0A140T998 X5D2R7 PSM8;PSMB8 Proteasome subunit beta type;Proteasome subunit beta type-8 0 27665300.0 8863500.0 7976800.0 10825000.0 False True 11620134.334256086 6786692.533322872 9704932.8407322 1.0 0.5840459617851184 0.8351824997514974 23.470123411288302 -10.317426155010912 5.804932447999465 1.00003167234857 0.7096142307683069 0.6406321920872813 0.10252606229779143 4.2030189496432925e-05 4.941888248136168e-06 0.09928124241438305 0.03309014431929694 4.814751143586644e-11 10.317426155010912 -0.29041744158026317 FQHGVIAAVDSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQHGVIAAVDSR 12 0 X5D2R7;P28062-2;P28062;Q5JNW7;A0A140T998 X5D2R7 PSM8;PSMB8 Proteasome subunit beta type;Proteasome subunit beta type-8 0 18196500.0 6982900.0 1818500.0 9395100.0 False True 6761231.661746209 2544636.533352219 6934241.46304151 1.0 0.3763569510196344 1.0255885036855281 22.688854648736605 -10.935992950419717 13.12764979629593 1.0431965108288737 0.7009727273596724 0.22048758298800597 0.2650476714910506 0.14190056378854193 0.0006918694027434932 0.1086755831928193 0.08554376813632444 1.1587961658813441e-11 10.935992950419717 -0.34222378346920124 FQHGVIAAVDSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQHGVIAAVDSR 12 0 X5D2R7;P28062-2;P28062;Q5JNW7;A0A140T998 X5D2R7 PSM8;PSMB8 Proteasome subunit beta type;Proteasome subunit beta type-8 0 14996900.0 8863500.0 2589200.0 3544200.0 False True 12140575.477081077 2474800.582660587 2707132.9550902434 1.0 0.2038454097445796 0.22298225979491307 23.533333472811194 -9.826460562015782 6.2444981436322875 1.0000000369471673 0.21341383541521658 0.9995562717798135 0.007812586319174773 12176125.411417907 19160590.416851673 4.542148909252321 0.0026744546622002796 1.4912121652589752e-10 9.826460562015782 -0.7865862015319507 FQHGVIAAVDSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQHGVIAAVDSR 12 0 X5D2R7;P28062-2;P28062;Q5JNW7;A0A140T998 X5D2R7 PSM8;PSMB8 Proteasome subunit beta type;Proteasome subunit beta type-8 0 11986300.0 6982900.0 3357900.0 1645500.0 False True 5806590.7449214095 3339810.326209037 1989566.4420676217 1.0 0.5751757740340353 0.34263934371606036 22.46925992417088 -9.568331668412283 0.15563494421185453 1.5981056092182409 3.858384965471586e-12 0.9997545894006615 0.0042636452526556064 1.0168510901723744 0.06278583259478086 0.4492410596394347 0.18241078448091963 2.70189415363742e-10 9.568331668412283 -1.5981056092143824 FQHGVIAAVDSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQHGVIAAVDSR 12 0 X5D2R7;P28062-2;P28062;Q5JNW7;A0A140T998 X5D2R7 PSM8;PSMB8 Proteasome subunit beta type;Proteasome subunit beta type-8 0 16500100.0 5202400.0 7640600.0 3657100.0 False True 6734609.354635282 7215393.8933728 2991545.325014807 1.0 1.071390115360827 0.44420472925512633 22.68316283298123 -6.878591292147889 1.0875882342429188 1.0434772455344667 0.40093342805600024 0.9725329317102953 0.04646298649254943 0.1288869952280624 0.2798678404238194 0.03294880895944367 0.07940366683968633 1.322539670449952e-07 6.878591292147889 -0.6425438174784666 down FQIAQYK(ub)CLVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQIAQYKCLVIK 12 1 K7ES52;P04183;K7ERV3;K7ERJ1;K7ENW5 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 1 48284200.0 32261000.0 8413700.0 7609500.0 True False 48942295.59502119 6912209.498461853 6105478.989637669 1.0 0.14123182033915507 0.1247485209961988 25.544578435548786 FQIAQYK(ub)CLVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQIAQYKCLVIK 12 1 K7ES52;P04183;K7ERV3;K7ERJ1;K7ENW5 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 1 32216800.0 12171000.0 18456000.0 1589800.0 True False 16670947.608907769 17640552.894169528 1214321.9829587706 1.0 1.0581613779857164 0.07284060939102965 23.99083277644328 -6.909532079366935 1.0291806229775602 1.0478190196379298 1.0122054773225866e-14 0.9826498019948728 0.0594585835302802 0.11129386924696617 0.21301075119505872 0.04469871994673035 0.10643915756322422 1.231595010029567e-07 6.909532079366935 -1.0478190196379196 down FQIAQYK(ub)CLVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQIAQYKCLVIK 12 1 K7ES52;P04183;K7ERV3;K7ERJ1;K7ENW5 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 1 21254000.0 15724000.0 2217600.0 3312400.0 True False 13075202.691309374 2205653.348640863 4005007.5251928247 1.0 0.16868980165843875 0.30630557856321505 23.64032997546236 -10.219337048853033 11.468160543610995 1.0000000008507206 0.2374976901108269 0.9761530249328857 0.056181405662231294 1.2690993135091023e-09 0.0 0.05439741212408619 0.018132470708028734 6.034800965447155e-11 10.219337048853033 -0.7625023107398937 FQIAQYK(ub)CLVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQIAQYKCLVIK 12 1 K7ES52;P04183;K7ERV3;K7ERJ1;K7ENW5 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 1 45114600.0 32261000.0 8117100.0 4736500.0 True False 41762500.45938194 7665376.2494956525 3874505.600594088 1.0 0.1835468701628862 0.09277475146303604 25.315704757641235 -13.999999999999998 0.3101322279873157 8.898210088467353 0.07270100752602915 0.9996722870721215 0.007385259958413307 17.279147384356055 0.1771979030566047 88.07503005455598 0.03143870722788353 1.0000000000000041e-14 13.999999999999998 -8.825509080941323 FQIATVTEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQIATVTEK 9 0 P28070 P28070 PSMB4 Proteasome subunit beta type-4 0 25510600.0 5240000.0 10324000.0 9946600.0 False True 6869690.744232188 8783699.442636816 8917421.246524435 1.0 1.2786164282593995 1.2980819047802883 22.711813723417773 -12.287846275538662 0.40703167755617053 1.331954348781732e-10 1.2991391194567983 0.9997809052545884 0.00201542924341678 7.024580150006186 0.20791530208592962 5.984457800446577 0.004885037956643719 5.15411049075353e-13 12.287846275538662 1.2991391193236028 FQIATVTEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQIATVTEK 9 0 P28070 P28070 PSMB4 Proteasome subunit beta type-4 0 18220200.0 5240000.0 6164200.0 6816000.0 False True 7177369.6056755185 5891845.261716514 5206201.179926385 1.0 0.8208919960116762 0.7253633943847021 22.775023784940664 -13.999999998801188 0.0780363351621549 1.97770428798728 0.4294337688300241 0.9998946590809473 0.0011683645036599964 12.278092129224937 0.07802435787114906 2.091469049362665 0.26942631926454536 1.000000002760366e-14 13.999999998801188 -1.5482705191572559 FQIATVTEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQIATVTEK 9 0 P28070 P28070 PSMB4 Proteasome subunit beta type-4 0 9193500.0 4519500.0 2822000.0 1852000.0 False True 3758164.497797806 2806797.3258768576 2239244.637319503 1.0 0.7468532384682931 0.5958346524298355 21.841596785353886 -11.420940522755892 0.07247868483861163 2.072529067264024 7.354616728330602e-09 0.9999586223107968 0.0010725894564368342 4.301567995595008 0.049038279208301096 1.151891596932263 0.4047029740665099 3.7936693625517315e-12 11.420940522755892 -2.072529059909407 FQINIYVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQINIYVK 8 0 A0A1W2PRF6;A0A1W2PPX5;A0A1W2PPU6;A0A1W2PQR6;A0A1W2PQB7;A0A1W2PS43;A0A1W2PRS1;Q14108-2;Q14108 A0A1W2PRF6 SCARB2 Lysosome membrane protein 2 0 31545700.0 7360200.0 9792500.0 14393000.0 False True 11165961.502695981 8044951.8658482935 11548217.241323985 1.0 0.7204889488384738 1.0342340190350567 23.4126041514172 -6.671707138508787 1.9310750830252696 0.8218547058266636 1.0329827336406907 0.28673772383773544 0.11868315313451175 0.45720935006119845 3.2885376520846066 0.04944694672645579 0.13182831244064408 2.1295746160589272e-07 6.671707138508787 0.21112802781402706 FQINIYVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQINIYVK 8 0 A0A1W2PRF6;A0A1W2PPX5;A0A1W2PPU6;A0A1W2PQR6;A0A1W2PQB7;A0A1W2PS43;A0A1W2PRS1;Q14108-2;Q14108 A0A1W2PRF6 SCARB2 Lysosome membrane protein 2 0 23187500.0 7360200.0 6932800.0 8894500.0 False True 9527923.991232233 6546983.585579009 7275792.265276921 1.0 0.687136420442025 0.7636282858650254 23.183730473509648 -10.513606821471694 7.021089169864726 1.0001056132879722 0.7253823531535258 0.9450114855803035 0.031227673293331766 5.164522993288761e-05 3.577787619411007e-06 0.030247604694374042 0.010078688217156673 3.064736767113243e-11 10.513606821471694 -0.27472326013444637 FQIYFDNCPLLTIPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQIYFDNCPLLTIPGR 16 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 94510000.0 36972000.0 27667000.0 29871000.0 False True 56089227.01525453 22729607.68674237 23966983.757075578 1.0 0.40524016636136956 0.42730101719100716 25.741220365096392 -10.171705256700859 6.4849300884971 1.0000024818598081 0.41627059177625436 0.9989299160987053 0.009006304637379817 3.23170214057123e-07 4.1277937884643186e-08 0.008720353989473734 0.002906772322619931 6.734335413991033e-11 10.171705256700859 -0.5837318900835538 FQIYFDNCPLLTIPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQIYFDNCPLLTIPGR 16 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 63463000.0 36972000.0 10455000.0 16036000.0 False True 47860982.82707515 9873170.059316382 13117612.543254877 1.0 0.20628849380274508 0.2740773751063505 25.512346687188842 -10.37384166627955 6.953347733739854 1.0000336365040328 0.24018293491089826 0.9940656223019964 0.02767469490465465 1.4431440916157705e-05 1.2995946890708574e-06 0.026797086590828852 0.008931969373091559 4.2282273755687e-11 10.37384166627955 -0.7598507015931345 FQK(ub)ENPGFDFSGAEISGNYTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQKENPGFDFSGAEISGNYTK 21 1 E5RFP0;Q8WVJ2 E5RFP0 NUDCD2 NudC domain-containing protein 2 1 9120300.0 2000100.0 1945500.0 5174700.0 True False 1936607.9202993857 2722348.2956484715 3819290.8323275885 1.0 1.405730229187339 1.9721549170041366 20.885100469214812 -6.966423066032185 0.33272464637167787 0.9331474448051654 2.463356204424045 0.9999395459139186 0.003099850097365912 0.07748131545257382 0.013174978227089873 0.008186712479458654 0.04929783402858779 1.080380990190443e-07 6.966423066032185 1.5302087596188794 FQK(ub)ENPGFDFSGAEISGNYTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQKENPGFDFSGAEISGNYTK 21 1 E5RFP0;Q8WVJ2 E5RFP0 NUDCD2 NudC domain-containing protein 2 1 8309900.0 2000100.0 3750500.0 2559300.0 True False 1663171.7694535651 3730295.3120840327 3094437.797133804 1.0 2.2428803690611105 1.860564166592655 20.66550574464909 -10.087784769541063 4.897662559776989 0.9999657119457173 2.0517222678276155 0.9098294868883816 0.15607993610246404 6.105617254237193e-05 1.1371955728507074e-05 0.15112887083867796 0.05037458276280551 8.16987158809433e-11 10.087784769541063 1.0517565558818982 FQK(ub)IPNGENETMIPVLTSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQKIPNGENETMIPVLTSK 19 1 B4E2Q0;P98194-2;P98194;P98194-5;P98194-8;P98194-9;P98194-6;P98194-7;D6REJ1;D6RHV9 B4E2Q0 ATP2C1 Calcium-transporting ATPase;Calcium-transporting ATPase type 2C member 1 1 25849700.0 8454900.0 8921100.0 8473700.0 True False 8186503.827478281 12483341.75292191 6254183.764449005 1.0 1.5248684928261005 0.7639627240454738 22.964816027582916 -6.72111396611846 1.7553632360282405 1.3189414106994013 0.7650770914281234 0.5177662279489448 0.22083644716911402 0.35314616023159356 2.12720478519073 0.09987053505713893 0.2503791773467708 1.900579470713052e-07 6.72111396611846 -0.5538643192712779 FQK(ub)IPNGENETMIPVLTSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQKIPNGENETMIPVLTSK 19 1 B4E2Q0;P98194-2;P98194;P98194-5;P98194-8;P98194-9;P98194-6;P98194-7;D6REJ1;D6RHV9 B4E2Q0 ATP2C1 Calcium-transporting ATPase;Calcium-transporting ATPase type 2C member 1 1 23906000.0 8454900.0 9627500.0 5823600.0 True False 7030623.96557821 9575634.746590864 7041287.834715902 1.0 1.361989318938543 1.0015167742137685 22.745221303017193 -10.156840374666345 13.008081672306858 0.9999996536419204 1.1817530465815744 0.2531557479630141 0.14716230014318346 0.0 0.0 0.14248928441097036 0.047496428136990114 6.968826068832477e-11 10.156840374666345 0.18175339293965398 FQLLVQQVALGTMMHCQTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQLLVQQVALGTMMHCQTLK 20 0 P43897;C9JT21;P43897-2;C9JG32;F8VPA7;F8VS27;P43897-4;P43897-3 P43897 TSFM Elongation factor Ts, mitochondrial;Elongation factor Ts 0 8288600.0 1360200.0 2050200.0 4878200.0 False True 1863102.6980228678 1959615.384895232 3726069.629682642 1.0 1.0518021293054773 1.9999271288892246 20.82927577009043 -6.918178740058993 0.8381267119655721 0.9776758506652637 2.1465929217455435 0.9936598412600252 0.03659944860671052 0.09925514428496518 0.11125545682556895 0.031233799410515666 0.09199100850617195 1.207316844456386e-07 6.918178740058993 1.1689170710802799 FQLLVQQVALGTMMHCQTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQLLVQQVALGTMMHCQTLK 20 0 P43897;C9JT21;P43897-2;C9JG32;F8VPA7;F8VS27;P43897-4;P43897-3 P43897 TSFM Elongation factor Ts, mitochondrial;Elongation factor Ts 0 8833740.0 5067900.0 787240.0 2978600.0 False True 4214183.39603706 782998.9818650944 3601411.4885096443 1.0 0.18580087962033454 0.8545929661951459 22.006821669145246 -10.637062083111573 9.044416339604497 1.0002503233735764 0.5201969229124428 0.4069682275049479 0.27303322601992663 0.0013788410045359931 5.5330870763765225e-05 0.26449401016702095 0.08812109477803848 2.3064174589779542e-11 10.637062083111573 -0.48005340046113365 FQLQLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQLQLLR 7 0 Q9P2R3;Q9P2R3-2;Q9P2R3-4 Q9P2R3 ANKFY1 Rabankyrin-5 0 3697300.0 1103400.0 1271800.0 1322100.0 False True 1446568.0853408002 1082052.397437573 1185301.7744787126 1.0 0.7480134591678412 0.8193888600822163 20.46420279723869 -9.940773799462766 6.3145807331933135 1.000000044308274 0.7837011596250151 0.9244983954403494 0.02913888540451557 1.8164432571695645e-08 3.0959026329360734e-09 0.028213610150259864 0.009404534824887376 1.1461097326665879e-10 9.940773799462766 -0.21629888468325886 FQMAYSNLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQMAYSNLLR 10 0 P37108 P37108 SRP14 Signal recognition particle 14 kDa protein 0 57579000.0 17497000.0 17237000.0 22845000.0 False True 22938736.441189047 14665306.789299741 20481218.544713832 1.0 0.6393249613769726 0.892866030229003 24.45128258824894 -10.105709223632816 5.622667696470222 1.0000021914861252 0.7660954958029487 0.5315720122553216 0.10350770792136012 2.843535874813422e-06 4.523335658955909e-07 0.10022184652390384 0.03340696908194069 7.839543537934835e-11 10.105709223632816 -0.23390669568317657 FQMAYSNLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQMAYSNLLR 10 0 P37108 P37108 SRP14 Signal recognition particle 14 kDa protein 0 49319000.0 22087000.0 6674000.0 20558000.0 False True 21385860.27481255 9338963.004450215 15173243.07321982 1.0 0.4366886758092818 0.7094988407405938 24.350153906929304 -10.462711211859268 6.209435857524611 1.0001968213642107 0.5730937582749458 0.7655331894459736 0.11137428345437272 0.0003036042192220463 2.6270196503769864e-05 0.10788654472556157 0.03594589541788079 3.445789855888185e-11 10.462711211859268 -0.42710306308926493 FQMAYSNLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQMAYSNLLR 10 0 P37108 P37108 SRP14 Signal recognition particle 14 kDa protein 0 23545300.0 9423300.0 0.0 14122000.0 False True 14295835.03550924 0.0 11330780.51010752 1.0 0.0 0.7925931211407476 23.769091556052075 -10.737498928342225 10.294980153568421 1.001197789018579 0.39629656057313634 0.43615744466812745 0.3235747867391277 0.008906218660272636 0.0002270901968478578 0.3136685714205065 0.10443331335777147 1.8302106225025013e-11 10.737498928342225 -0.6049012284454427 FQMAYSNLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQMAYSNLLR 10 0 P37108 P37108 SRP14 Signal recognition particle 14 kDa protein 0 57654000.0 17497000.0 18726000.0 21431000.0 False True 23966113.73864591 17898623.401398953 16369439.185299657 1.0 0.7468304455443274 0.683024346951319 24.51449264977183 -13.99999999944473 0.1935357074657179 2.374131243645003 0.6388427072648051 0.9994878488970025 0.0030978246928860063 12.410466230073194 0.1395104317318898 6.43910666241735 0.042677556505051784 1.0000000012785555e-14 13.99999999944473 -1.735288536380198 FQMAYSNLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQMAYSNLLR 10 0 P37108 P37108 SRP14 Signal recognition particle 14 kDa protein 0 44024500.0 22087000.0 12190000.0 9747500.0 False True 18366319.120004468 12124330.050474431 11785657.182652187 1.0 0.6601393546118174 0.6416994665967298 24.13055918236358 -13.999999999999998 0.4152204030341741 7.3203575029034615 0.640990194379628 0.9998581788058771 0.001961742954465788 29.15350369885457 0.21427594328866154 166.91532628061785 0.004529813797060171 1.0000000000000041e-14 13.999999999999998 -6.679367308523833 FQMAYSNLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQMAYSNLLR 10 0 P37108 P37108 SRP14 Signal recognition particle 14 kDa protein 0 46145300.0 9423300.0 22977000.0 13745000.0 False True 12198647.611013118 21698309.751593698 11243551.035609785 1.0 1.7787471565293964 0.9217047163046945 23.540217878144524 -6.667537873181123 1.9464516083960046 1.4981241501218394 0.9252281062483122 0.2680897533628074 0.33098432035995395 0.4667620440797599 3.4070250116105574 0.13702337904924503 0.3672246996524007 2.1501171675686385e-07 6.667537873181123 -0.5728960438735272 FQMTQEVVCDECPNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQMTQEVVCDECPNVK 16 0 Q9UBS4 Q9UBS4 DNAJB11 DnaJ homolog subfamily B member 11 0 9227400.0 1706400.0 3788900.0 3732100.0 False True 2237106.9248011084 3223610.889016522 3345938.0928311017 1.0 1.44097309488375 1.4956540770301243 21.09320278244617 -11.877412167242035 0.3380851380508467 4.3286064040456334e-14 1.5053420076658643 0.9995566144081054 0.004672292227481651 4.941154601823996 0.17845787713655592 3.5200859705158343 0.01699696212403821 1.32613529142456e-12 11.877412167242035 1.505342007665821 FQMTQEVVCDECPNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQMTQEVVCDECPNVK 16 0 Q9UBS4 Q9UBS4 DNAJB11 DnaJ homolog subfamily B member 11 0 7437200.0 1706400.0 3084100.0 2646700.0 False True 2337302.1937260893 2947834.2642451436 2021603.9704975323 1.0 1.2612122951657159 0.8649305066003142 21.15641284396906 -6.72891900896211 1.7270230684394874 1.1573856452234483 0.8652067537383684 0.554282946571395 0.10981739277164743 0.33828369017370596 1.9761338700615572 0.0503993379950595 0.1252229807130902 1.8667277821189404e-07 6.72891900896211 -0.2921788914850799 FQNVADLHLYLYSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQNVADLHLYLYSAK 15 0 P41250 P41250 GARS Glycine--tRNA ligase 0 66685000.0 29521000.0 18557000.0 18607000.0 False True 28583872.01397844 25966906.873476584 13733268.50196522 1.0 0.9084460936845059 0.4804551495070089 24.768698023507223 -6.941316225254434 0.6472026870798177 1.0047161837408554 0.36042895773894595 0.9983312675267982 0.009250195608952018 0.08717125501696218 0.051913455462234324 0.009096844917179638 0.036627980006730836 1.1446791563331248e-07 6.941316225254434 -0.6442872260019095 down FQNVADLHLYLYSAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQNVADLHLYLYSAK 15 0 P41250 P41250 GARS Glycine--tRNA ligase 0 447834000.0 95384000.0 178150000.0 174300000.0 False True 144704501.50446367 146357740.60769674 139849528.601596 1.0 1.0114249320929527 0.9664490540902909 27.10853456139115 -6.839348055592301 1.285293671986727 1.0060787997062117 0.9649876694093902 0.923339551947108 0.005284896946373139 0.16956863080599097 0.5444054811863288 0.0032243994256517146 0.007427665945805123 1.4476112329074586e-07 6.839348055592301 -0.04109113029682154 FQNVADLHLYLYSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQNVADLHLYLYSAK 15 0 P41250 P41250 GARS Glycine--tRNA ligase 0 16318300.0 4422200.0 3738600.0 8157500.0 False True 6057206.8454615 3573416.2901030746 6230866.508986144 1.0 0.5899445703724875 1.0286699245964768 22.530221247649873 -11.794959791079574 13.581569830784112 0.9015867041054002 0.828376522735917 0.0 0.20528180686114264 0.0 0.0 0.0 0.05960666820735165 1.603393833171662e-12 11.794959791079574 -0.07321018136948321 FQNVADLHLYLYSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQNVADLHLYLYSAK 15 0 P41250 P41250 GARS Glycine--tRNA ligase 0 57847000.0 29521000.0 13924000.0 14402000.0 False True 24548019.502044294 13848988.6483024 17413391.612675715 1.0 0.5641591024135 0.7093603462073824 24.5491032989415 -10.388051736350576 5.139890386077195 1.0002599243697028 0.6367597243104186 0.8929820392210523 0.05927815955215802 0.00017668666178042306 2.1035966665531964e-05 0.057436352556160926 0.019131943728266498 4.092119084961811e-11 10.388051736350576 -0.3635002000592842 FQNVADLHLYLYSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQNVADLHLYLYSAK 15 0 P41250 P41250 GARS Glycine--tRNA ligase 0 316392000.0 95384000.0 125340000.0 95668000.0 False True 123476468.29973306 118364718.81728488 78257405.63657454 1.0 0.9586014278442135 0.633783964784355 26.8796608834836 -6.930459318552756 0.7430131909511309 1.0048563211815846 0.566314121929746 0.9966277117317246 0.009509345709397217 0.09240015356087339 0.07651726201702183 0.00868723903467854 0.029316531876701964 1.1736556165909955e-07 6.930459318552756 -0.4385421992518387 FQNVADLHLYLYSAK(ub)AQVSGQSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQNVADLHLYLYSAKAQVSGQSAR 24 1 P41250 P41250 GARS Glycine--tRNA ligase 1 18841000.0 7341200.0 5534300.0 5965500.0 True False 7108157.624369712 7744174.850993238 4402956.588836117 1.0 1.0894770853762437 0.6194230377982834 22.76104424300578 -6.857419762629776 1.1986819682946934 1.0482525398655862 0.5977548019842338 0.9504289202304401 0.04537431991904326 0.14948353903683875 0.40960374775554964 0.029553012931784348 0.06879840281883615 1.388609836581737e-07 6.857419762629776 -0.4504977378813524 FQNVADLHLYLYSAK(ub)AQVSGQSAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQNVADLHLYLYSAKAQVSGQSAR 24 1 P41250 P41250 GARS Glycine--tRNA ligase 1 46141000.0 18323000.0 0.0 27818000.0 True False 27797330.590731006 0.0 22319760.106937483 1.0 0.0 0.8029461690245893 24.72844301016667 -9.743616690033283 10.31502998227345 0.9999871714640496 0.4014730681621012 0.4255696360688346 0.3278014009224711 0.0 0.0 0.31739234162124014 0.10579744720708002 1.8046097936694026e-10 9.743616690033283 -0.5985141033019483 FQNVADLHLYLYSAK(ub)AQVSGQSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQNVADLHLYLYSAKAQVSGQSAR 24 1 P41250 P41250 GARS Glycine--tRNA ligase 1 21113200.0 7341200.0 9691800.0 4080200.0 True False 6104533.070302745 9639588.349728316 4933350.9552867375 1.0 1.579086924210938 0.8081455040822763 22.541449518440057 -6.705680550874957 1.8103389871252713 1.3575600201917601 0.8101551441429561 0.444720782497145 0.2441942837211041 0.3838072854408249 2.449130069570336 0.10744881672390422 0.27443677475100825 1.9693343182612207e-07 6.705680550874957 -0.5474048760488041 FQNVADLHLYLYSAK(ub)AQVSGQSAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQNVADLHLYLYSAKAQVSGQSAR 24 1 P41250 P41250 GARS Glycine--tRNA ligase 1 69529000.0 18323000.0 32605000.0 18601000.0 True False 23719484.700327177 30790503.087901488 15215808.862377413 1.0 1.2981101181964876 0.6414898575839437 24.49956933225912 -6.783261707039122 1.5230422151912633 1.1680828631290028 0.6357354514688701 0.7787951149491281 0.12625471611691275 0.24554228509555517 1.1251685292636329 0.06527598567286952 0.1536171948802093 1.6471695035623562e-07 6.783261707039122 -0.5323474116601327 FQPFHGLFDGVPTTAYFSASPPALCPQGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQPFHGLFDGVPTTAYFSASPPALCPQGR 29 0 A0A3B3IT68;F5H2B5;Q96BZ4 A0A3B3IT68 PLD4 Phospholipase D4 0 86075000.0 34468000.0 26744000.0 24863000.0 False True 52290475.948333696 21971324.24817426 19948817.15215996 1.0 0.42017831832097535 0.38150001105116454 25.640044865877947 -13.999999999999998 0.3846985761264181 9.863087435034956 0.3783777934219983 0.9998149827115196 0.003847870498704281 24.640154132868936 0.20274955186390733 181.211149410373 0.010338210099724606 1.0000000000000041e-14 13.999999999999998 -9.484709641612957 FQPFHGLFDGVPTTAYFSASPPALCPQGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQPFHGLFDGVPTTAYFSASPPALCPQGR 29 0 A0A3B3IT68;F5H2B5;Q96BZ4 A0A3B3IT68 PLD4 Phospholipase D4 0 65810000.0 34468000.0 14274000.0 17068000.0 False True 44619505.46585597 13479639.35214556 13961799.132469097 1.0 0.3021019442373815 0.3129079757092565 25.411171187970396 -9.969880842840338 5.080416311664869 1.0000039287111366 0.30750495996808785 0.9998174079650726 0.00441154390337478 6062508.40231533 1.1919264681693176 286.9133990359273 0.0015101888140074203 1.0718133377880925e-10 9.969880842840338 -0.6924989687430487 FQQQLEQLSAMGFLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQQQLEQLSAMGFLNR 16 0 Q9UMX0-2;Q9UMX0;Q9UMX0-3 Q9UMX0-2 UBQLN1 Ubiquilin-1 0 4899900.0 1182100.0 2049900.0 1667900.0 False True 1549744.5474726823 1744062.9104476185 1495321.7076265346 1.0 1.1253873506390648 0.9648827028074399 20.563598997425704 -6.698270702180555 1.8368697738440087 1.0779921240591293 0.9653730533965865 0.40941161809589244 0.05294455880178204 0.3991517834488953 2.6170607910715824 0.023004315137254604 0.059291313971231184 2.003222999582312e-07 6.698270702180555 -0.11261907066254273 FQQQLEQLSAMGFLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQQQLEQLSAMGFLNR 16 0 Q9UMX0-2;Q9UMX0;Q9UMX0-3 Q9UMX0-2 UBQLN1 Ubiquilin-1 0 16752300.0 5289400.0 4453900.0 7009000.0 False True 5121490.892271177 6232365.496781669 5173132.634507141 1.0 1.2169045357840835 1.0100833416132589 22.28813241661709 -10.814306018619758 2.69516764406466 0.964161377356492 1.1134939384704903 0.28648271485044785 0.08443440070016286 37173295.55472103 24138149.881701007 8636765.267926242 0.03111924345208443 1.5335360205172967e-11 10.814306018619758 0.14933256111399829 FQQQLEQLSAMGFLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQQQLEQLSAMGFLNR 16 0 Q9UMX0-2;Q9UMX0;Q9UMX0-3 Q9UMX0-2 UBQLN1 Ubiquilin-1 0 10488100.0 1182100.0 3279800.0 6026200.0 False True 1619154.3150513386 3134887.5911517795 4602935.673484799 1.0 1.9361265087647817 2.8428023386633496 20.626809058948595 -6.971515928398657 0.2189709176847085 0.5764098625017791 4.228090488827724 0.9999919152757275 0.0021392061602066572 0.07581381709735172 0.007243874419239645 0.025313222283188927 0.0920976484801829 1.0677856291884385e-07 6.971515928398657 3.6516806263259447 FQQQLEQLSAMGFLNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQQQLEQLSAMGFLNR 16 0 Q9UMX0-2;Q9UMX0;Q9UMX0-3 Q9UMX0-2 UBQLN1 Ubiquilin-1 0 13041700.0 5289400.0 2825200.0 4927100.0 False True 4398370.460150841 2809980.086841705 5957333.829663556 1.0 0.6388684428244676 1.354441123965545 22.068537692051365 -6.7694871050324625 1.5762716127550471 0.7927281467882141 1.3584018832161713 0.7286403140039484 0.15217983816496783 0.26726286648475434 1.310424896614234 0.07609969332172119 0.18124494750304873 1.7002504363208342e-07 6.7694871050324625 0.5656737364279572 FQQSDDLK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQQSDDLKK 9 1 Q8N543;A0A0A0MTR2;H3BUA6;H3BR79 Q8N543 OGFOD1 Prolyl 3-hydroxylase OGFOD1 1 15796520.0 635520.0 1840000.0 13321000.0 True False 964130.3027354362 1511637.6240143832 10688098.511198286 1.0 1.5678768935335359 11.085740673095689 19.878868615089534 -6.919127401295988 0.8311661113362522 0.7833152729169786 12.590226869955686 0.9939351879182826 0.3602917513759235 0.09868813899989341 0.10829268718790043 0.3090018743425444 0.9180349134105756 1.2046824921219845e-07 6.919127401295988 11.806911597038708 up FQQSDDLK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQQSDDLKK 9 1 Q8N543;A0A0A0MTR2;H3BUA6;H3BR79 Q8N543 OGFOD1 Prolyl 3-hydroxylase OGFOD1 1 3185040.0 334940.0 1122800.0 1727300.0 True False 278517.4503578712 1116751.2535416507 2088470.4438671547 1.0 4.009627591042215 7.4985263622930916 18.087408196099304 -6.9691858627738545 0.276943055888342 0.2025333763729786 11.411492795166444 0.9999753171873443 0.013192584535150731 0.0765677928621926 0.009972097345268272 0.06560045302568687 0.3214916640286557 1.0735298809595452e-07 6.9691858627738545 11.208959418793466 FQQSDDLK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQQSDDLKK 9 1 Q8N543;A0A0A0MTR2;H3BUA6;H3BR79 Q8N543 OGFOD1 Prolyl 3-hydroxylase OGFOD1 1 22408220.0 635520.0 1764700.0 20008000.0 True False 822693.1679720543 1666492.8937040295 16366749.29941654 1.0 2.02565544310031 19.894111117709553 19.649994937181983 -6.918701680255804 0.8342919766306849 0.5869905640428827 22.691302464503423 0.9938127343202563 0.6823786559980791 0.09894194618956488 0.10961477800760946 0.5839316310286374 1.7280402523040463 1.205863971865162e-07 6.918701680255804 22.10431190046054 up FQQVPTDALANK(ub)LFGAPEPSTIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQQVPTDALANKLFGAPEPSTIAR 24 1 Q6PKG0-3;Q6PKG0;A0A0B4J210;E5RH50;H0YC33 Q6PKG0-3 LARP1 La-related protein 1 1 8028200.0 2709500.0 3828300.0 1490400.0 True False 3552180.7388353213 3257132.5625965255 1336187.7049263094 1.0 0.9169388615243899 0.3761598305846382 21.760273558778987 -6.934132162216885 0.7120583152032548 1.0070985345005685 0.2524785053981376 0.9972898467218664 0.014399028212697465 0.0905483503398952 0.06758080001980771 0.013457019543815547 0.047868243154911595 1.163771822586265e-07 6.934132162216885 -0.754620029102431 down FQQVPTDALANK(ub)LFGAPEPSTIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQQVPTDALANKLFGAPEPSTIAR 24 1 Q6PKG0-3;Q6PKG0;A0A0B4J210;E5RH50;H0YC33 Q6PKG0-3 LARP1 La-related protein 1 1 36629600.0 18022000.0 9188500.0 9419100.0 True False 17449901.474744033 12857515.967394484 6951955.143056951 1.0 0.7368245594970092 0.39839509427138053 24.05671555495595 -6.967689432617774 0.30842489597605055 1.0531172080130706 0.07136923491882036 0.9999583372574102 0.0015894118455277238 0.07705979132627468 0.011700037373354705 0.005393182974271424 0.03009229863229901 1.0772352776336835e-07 6.967689432617774 -0.9817479730942502 down FQQVPTDALANK(ub)LFGAPEPSTIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQQVPTDALANKLFGAPEPSTIAR 24 1 Q6PKG0-3;Q6PKG0;A0A0B4J210;E5RH50;H0YC33 Q6PKG0-3 LARP1 La-related protein 1 1 12883400.0 2709500.0 5439600.0 4734300.0 True False 3711275.3714843104 5199260.485648286 3616155.845969115 1.0 1.4009363265245558 0.9743701245544728 21.82348362030188 -6.66016347564976 1.9726270965909354 1.2580456978849552 0.9761589003811344 0.2362172703340295 0.1707033422029607 0.4840235168197828 3.6209574328657244 0.06991531497526657 0.18919899993833603 2.1869382691420599e-07 6.66016347564976 -0.28188679750382084 FQQVPTDALANK(ub)LFGAPEPSTIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQQVPTDALANKLFGAPEPSTIAR 24 1 Q6PKG0-3;Q6PKG0;A0A0B4J210;E5RH50;H0YC33 Q6PKG0-3 LARP1 La-related protein 1 1 38969300.0 18022000.0 14336000.0 6611300.0 True False 14986091.509970581 14258769.122526795 7993692.262802603 1.0 0.9514668393049727 0.5334074102966888 23.837120830390226 -6.928747855385642 0.7570076001973906 1.0066618287116078 0.45025828166281434 0.9962861780120106 0.012764347045045246 0.09329356668249424 0.08090617668395335 0.01154340062635696 0.03809106981146784 1.1782898717251756e-07 6.928747855385642 -0.5564035470487935 FQSEK(ub)AAGSVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQSEKAAGSVSK 12 1 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 13642000.0 1642900.0 6441000.0 5558100.0 True False 2153857.809866233 5480027.906821354 4983001.1290599285 1.0 2.54428490205753 2.313523718341185 21.038491580686372 -10.218983837693656 5.462000308517602 0.9999225466572179 2.4289043101994476 0.980814749384628 0.0942078587580578 8.887011801094426e-05 1.270799825650052e-05 0.09122122382374705 0.030405455670920744 6.039711057945817e-11 10.218983837693656 1.4289817635422297 FQSEK(ub)AAGSVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQSEKAAGSVSK 12 1 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 17593500.0 8772500.0 1645000.0 7176000.0 True False 8494021.789323725 2301857.0785616753 5296390.32461453 1.0 0.270997312657582 0.6235432938577636 23.01801637889352 -10.630974761739386 6.635334061574749 1.001967465228553 0.4472703032598806 0.7662145007463006 0.14392629413487934 0.0042001214905381685 0.00023359017989095464 0.13972553249231023 0.046452011688811475 2.3389731600247294e-11 10.630974761739386 -0.5546971619686725 FQSEK(ub)AAGSVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQSEKAAGSVSK 12 1 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 51487500.0 12703700.0 20467000.0 18316800.0 True False 19272441.664873097 16814503.940599132 14696476.451461378 1.0 0.8724636054416539 0.7625643240756516 24.200036025396454 -6.972861044294619 0.1769668151504779 1.0884508489239224 0.543614096307804 0.9999969552610268 0.00016919663061191532 0.07538484262396074 0.005562075141595513 0.004347869753341945 0.01244904595079955 1.0644835530647398e-07 6.972861044294619 -0.5448367526161184 FQSEK(ub)AAGSVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQSEKAAGSVSK 12 1 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 13030600.0 1642900.0 6911200.0 4476500.0 True False 2250324.5277031125 6605840.331717854 3419242.896411459 1.0 2.9355056350296196 1.519444353166897 21.101701642209264 -6.565791797817579 2.323065238755426 2.3290848376132254 1.5220727918307762 0.0 0.8438531626962845 0.7431129988002259 7.522588578464694 0.3078046338965594 0.947370815110672 2.7177418508361644e-07 6.565791797817579 -0.8070120457824492 FQSEK(ub)AAGSVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQSEKAAGSVSK 12 1 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 15531700.0 8772500.0 1974000.0 4785200.0 True False 7294722.437643827 1963365.6701916778 5785763.195735035 1.0 0.2691487835177782 0.7931437070008409 22.798421654327797 -9.985614088225702 6.556441876098613 1.0000001047792255 0.531146245260901 0.516319169485282 0.2139200317237214 3.2763364077200817e-07 5.084086576466178e-08 0.20712722636753356 0.06904239335717524 1.0336795199268662e-10 9.985614088225702 -0.4688538595183245 FQSEK(ub)AAGSVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQSEKAAGSVSK 12 1 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 39635900.0 12703700.0 15571500.0 11360700.0 True False 16445190.07736433 14704932.3365514 9293169.17062582 1.0 0.8941783139856636 0.5650995292184082 23.971162347488903 -6.950640120513312 0.5517706304513283 1.0045040203355509 0.4392671368692763 0.9992505688221383 0.0050694758266295135 0.08322970050020813 0.03490633173693855 0.005489855254208427 0.02730911924477554 1.1203658936319676e-07 6.950640120513312 -0.5652368834662745 FQSGDFHVINGVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQSGDFHVINGVLR 14 0 P55060-3;P55060;P55060-4;P55060-2 P55060-3 CSE1L Exportin-2 0 36532100.0 7938100.0 13059000.0 15535000.0 False True 10406925.972669749 11110648.10358332 13927587.222242476 1.0 1.0676205569984505 1.338299826367416 23.311040648419016 -6.944858400543786 0.6127045145163488 0.9970167432868449 1.4230652207420855 0.9987334425871965 0.005201940797442307 0.08561853756827968 0.045030888719793334 0.005274204695865958 0.022846264931967127 1.1353809403787049e-07 6.944858400543786 0.42604847745524066 FQSGDFHVINGVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQSGDFHVINGVLR 14 0 P55060-3;P55060;P55060-4;P55060-2 P55060-3 CSE1L Exportin-2 0 23837400.0 4348900.0 2166500.0 17322000.0 False True 4210846.549967507 3031594.7481482443 12784848.551138911 1.0 0.7199489965198655 3.0361706130653388 22.005678871657445 -6.876677902649987 1.098117907371903 0.8329876196850791 3.1902370292894853 0.970907407327697 0.17606111757670134 0.1306154866702185 0.2903915523505458 0.12384908801296293 0.2971383972769662 1.3283792936924355e-07 6.876677902649987 2.3572494096044063 up FQSGDFHVINGVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQSGDFHVINGVLR 14 0 P55060-3;P55060;P55060-4;P55060-2 P55060-3 CSE1L Exportin-2 0 31051300.0 7938100.0 8994200.0 14119000.0 False True 10873030.089086408 8596806.504157979 10784382.989932615 1.0 0.7906541629813805 0.991847065773986 23.374250709941908 -10.644667378844908 8.285134639500082 1.0001237223624027 0.8912506143881581 0.28034433927100444 0.08213665861854336 0.00018792220319342203 8.059707340737503e-06 0.07961851693832361 0.026509492578561864 2.2663794370280592e-11 10.644667378844908 -0.10887310797424454 FQSLGVAFYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQSLGVAFYR 10 0 P51149;C9J8S3;C9J592;C9IZZ0 P51149 RAB7A Ras-related protein Rab-7a 0 42728000.0 13184000.0 15016000.0 14528000.0 False True 17284351.674037617 12775671.331909558 13024781.922416411 1.0 0.7391466901879559 0.7535591827826903 24.042963154176178 -10.433115003072146 8.961000628971153 1.000002110440076 0.7463529364870785 0.9975843732197428 0.005883875463123415 2.480797898596709e-07 1.5697931960270867e-08 0.005697085279432627 0.0018990126399862912 3.688799046289262e-11 10.433115003072146 -0.2536491739529976 FQSLGVAFYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQSLGVAFYR 10 0 P51149;C9J8S3;C9J592;C9IZZ0 P51149 RAB7A Ras-related protein Rab-7a 0 19415600.0 9581000.0 3696200.0 6138400.0 False True 9276856.399374256 5172111.93542837 4530568.891947302 1.0 0.5575285110349708 0.48837329122103246 23.145204578840154 -13.999999999999998 0.26126321925999957 4.260545967684313 0.46340166471358835 0.999564922221211 0.004727545609446531 14.473294863012946 0.16175331283414235 24.93380595805974 0.030033839645495018 1.0000000000000041e-14 13.999999999999998 -3.7971443029707244 FQSLGVAFYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQSLGVAFYR 10 0 P51149;C9J8S3;C9J592;C9IZZ0 P51149 RAB7A Ras-related protein Rab-7a 0 31716400.0 7128800.0 7756600.0 16831000.0 False True 10814910.785089973 6372374.127407595 13504345.472710636 1.0 0.5892211460674182 1.2486783979141522 23.366518428407485 -6.738235810265058 1.69299041160802 0.7550960111468789 1.2489324196923932 0.5970971259337406 0.1726001770358725 0.3210022370021607 1.805826133603484 0.08067264019105834 0.19836069500769174 1.827107876147848e-07 6.738235810265058 0.49383640854551436 FQSLGVAFYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQSLGVAFYR 10 0 P51149;C9J8S3;C9J592;C9IZZ0 P51149 RAB7A Ras-related protein Rab-7a 0 32582700.0 13184000.0 7793700.0 11605000.0 False True 18058481.08420343 7449348.5636805985 8864138.012477372 1.0 0.41251246596796454 0.4908573412761295 24.10617321569907 -10.630076224356314 6.577841703906767 1.002021762628045 0.4516849036224825 0.9849192587644311 0.031984161411162865 0.0009509129975014877 5.34772179727851e-05 0.031053531492983906 0.010322843707320312 2.343817408636481e-11 10.630076224356314 -0.5503368590055625 FQSLGVAFYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQSLGVAFYR 10 0 P51149;C9J8S3;C9J592;C9IZZ0 P51149 RAB7A Ras-related protein Rab-7a 0 17115600.0 9581000.0 4098700.0 3435900.0 False True 7967026.010266806 4076619.4895717506 4154330.804193345 1.0 0.5116864792857918 0.5214405976382925 22.92560985427443 -10.544501758986598 6.297610081909995 1.0006543183312582 0.5165635384620422 0.9996947702695032 0.0039821021423906144 3.662918638470271e-05 2.649332591006978e-06 0.0038605233963260126 0.0012852179400313145 2.8542909532673684e-11 10.544501758986598 -0.484090779869216 FQSLGVAFYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQSLGVAFYR 10 0 P51149;C9J8S3;C9J592;C9IZZ0 P51149 RAB7A Ras-related protein Rab-7a 0 41895800.0 7128800.0 18525000.0 16242000.0 False True 9228372.129656319 17494067.465216253 13286122.656993385 1.0 1.8956829242935789 1.4397038253688395 23.137644750499934 -10.195628190144795 4.760612015440939 0.9999099859641394 1.6676933747249036 0.7408605767819005 0.1861526877038536 0.00019546395101227248 3.3026273402905355e-05 0.18026804791680676 0.060080521598678896 6.373409301638345e-11 10.195628190144795 0.6677833887607643 FQSSHHPTDITSLDQYVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQSSHHPTDITSLDQYVER 19 0 P14625 P14625 HSP90B1 Endoplasmin 0 100162000.0 4937000.0 57777000.0 37448000.0 False True 6472454.809976016 49156896.81298204 33573240.186581075 1.0 7.594784089835026 5.18709534052436 22.625881556734058 -9.438832181038938 9.083397850713974 1.0000179292161977 6.3909397151745555 0.8698674136023434 0.9829348159298497 0.0 0.0 0.9517225289197109 0.31724084770040906 3.6405568641625195e-10 9.438832181038938 5.390921785958358 FQSSHHPTDITSLDQYVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQSSHHPTDITSLDQYVER 19 0 P14625 P14625 HSP90B1 Endoplasmin 0 70779600.0 20286400.0 7386200.0 43107000.0 False True 19642419.33621395 10335548.178524151 31815983.51771994 1.0 0.5261850896070074 1.619758898999884 24.227469300045254 -6.7889721994908845 1.5006526456914198 0.7348305178325485 1.6310279999136161 0.797911990844541 0.2012927363007966 0.23688710843727112 1.053921283162865 0.10559246944611236 0.2473812872112504 1.625652815395092e-07 6.7889721994908845 0.8961974820810676 FQSSHHPTDITSLDQYVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQSSHHPTDITSLDQYVER 19 0 P14625 P14625 HSP90B1 Endoplasmin 0 119404000.0 4937000.0 52010000.0 62457000.0 False True 6762342.317408406 49712026.225929745 47705942.94229201 1.0 7.351302831558124 7.054647739361233 22.68909161825695 -9.981540818679157 6.742092494265518 0.9999991566737011 7.2029752854597096 0.9982875400294744 0.12110893424689116 1.5356175735221006e-06 2.3221771130455923e-07 0.117263235312033 0.03908774045124513 1.0434200586522287e-10 9.981540818679157 6.202976128786008 FQSSHHPTDITSLDQYVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQSSHHPTDITSLDQYVER 19 0 P14625 P14625 HSP90B1 Endoplasmin 0 25669900.0 20286400.0 2485600.0 2897900.0 False True 16869040.439899437 2472209.5794470296 3503837.4916242855 1.0 0.146553064962702 0.2077081683518196 24.00787457547953 -9.980382763054875 6.603194032214691 1.0000001522651256 0.17713061665761617 0.9958745670787892 0.024966466411776196 5.5943224033735905e-08 8.646457237173654e-09 0.024173681659167466 0.00805789238553385 1.0462060736283689e-10 9.980382763054875 -0.8228695356075094 FQSSHHPTDITSLDQYVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQSSHHPTDITSLDQYVER 19 0 P14625 P14625 HSP90B1 Endoplasmin 0 10764500.0 3227700.0 3722700.0 3814100.0 False True 4178321.2774789133 3515528.4724837006 3119972.9359708466 1.0 0.841373422247912 0.7467048914566364 21.994491997010503 -13.999999680936329 0.05351080881516984 2.0912900193703594 0.24577068273774968 0.9999690151911403 0.0005816621709915647 12.530023335113444 0.05661977874490658 1.9459565656381863 0.4758726350253127 1.0000007346715235e-14 13.999999680936329 -1.8455193366326097 FQTEIQTVNK(ub)QFPCEPFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQTEIQTVNKQFPCEPFK 18 1 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 1 28453100.0 8554200.0 11408000.0 8490900.0 True False 11214639.038990645 9705970.868035706 7612343.11846403 1.0 0.8654733187836312 0.6787862803250034 23.418879849946578 -6.966517897730853 0.33097027742186785 1.0224886430988227 0.5156506491345911 0.9999410977889932 0.001010828517803636 0.07744962655581501 0.013064029890068624 0.002714722688758699 0.016270587515758175 1.080145106052552e-07 6.966517897730853 -0.5068379939642316 FQTEIQTVNK(ub)QFPCEPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQTEIQTVNKQFPCEPFK 18 1 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 1 17349300.0 10203000.0 3986500.0 3159800.0 True False 9879111.349839846 5578330.239322867 2332153.588031906 1.0 0.5646591117138587 0.23606916709868986 23.23594984303299 -7.993956997149099 0.28051035399777036 1.142523485203395 9.62356119486207e-24 0.9993862144897613 0.007751672928710924 0.10052707483481627 0.05260911290856799 0.06134776311327787 0.09198459333629207 1.0140117859044815e-08 7.993956997149099 -1.142523485203395 down FQTEIQTVNK(ub)QFPCEPFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQTEIQTVNKQFPCEPFK 18 1 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 1 81346000.0 27217000.0 28190000.0 25939000.0 True False 41290178.82922705 23159274.25052468 20812145.28053245 1.0 0.5608906259841989 0.5040458983384367 25.29929533110248 -13.999999999999998 0.2882101008513537 4.745897012095619 0.4882742585715913 0.9996234577897792 0.004300367551693084 15.860158222241123 0.17020828938208657 35.188084101262326 0.02164377786926688 1.0000000000000041e-14 13.999999999999998 -4.257622753524028 FQTEIQTVNK(ub)QFPCEPFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQTEIQTVNKQFPCEPFK 18 1 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 1 27811900.0 8554200.0 8393700.0 10864000.0 True False 11716918.908562886 8022838.579745926 8298146.951103321 1.0 0.684722548850511 0.7082192012986385 23.48208991146947 -10.693293817562834 6.697779572058253 1.0026788596842948 0.6964708750745751 0.9955256995572311 0.00959246819357159 0.0003864460204343622 1.7696197695633242e-05 0.009353880217732377 0.003095955796893922 2.0263113751123268e-11 10.693293817562834 -0.30620798460971976 FQTEIQTVNK(ub)QFPCEPFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQTEIQTVNKQFPCEPFK 18 1 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 1 66764000.0 27217000.0 21491000.0 18056000.0 True False 35232943.02727752 20295006.957892716 14769993.270205181 1.0 0.5760236078541671 0.4192097509075577 25.07042165319493 -13.999999999999956 0.13818568381462995 3.022252625359714 0.22083607277376757 0.9996102652152734 0.004843150442606545 11.932604837188205 0.11633160100407694 6.5137392892152 0.177136455760684 1.0000000000001022e-14 13.999999999999956 -2.8014165525859465 FQTMEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQTMEEK 7 0 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 0 5823620.0 2064200.0 675620.0 3083800.0 False True 1998673.100885953 945398.589311756 2276060.2679830347 1.0 0.4730131149974894 1.138785660833742 20.930611096285713 -6.695765723361939 1.8462967311188565 0.6714105529899619 1.1366356294653808 0.39740866946242026 0.22262474939824853 0.4043705232231797 2.676858386001341 0.09631317126808157 0.24896481436776977 2.0148108301337165e-07 6.695765723361939 0.4652250764754189 FQTMEEK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQTMEEKK 8 1 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 1 2144700.0 647580.0 653660.0 843460.0 True False 848983.6511736413 556136.4759467231 756186.8502396302 1.0 0.6550614669409899 0.8906965984495365 19.695377246592262 -10.090232992121157 5.18486442916981 1.0000043575123956 0.7728790326948769 0.5533161587428541 0.09619763961293949 4.84561561966503e-06 8.502172542178894e-07 0.09314475008593187 0.031047654680254243 8.123945623987296e-11 10.090232992121157 -0.22712532481751868 FQTMEEK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQTMEEKK 8 1 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 1 2817950.0 876070.0 963930.0 977950.0 True False 848259.637386474 1348832.2758285445 721795.5571288706 1.0 1.5901172428578088 0.8509134766246278 19.69414639044962 -6.694101716557465 1.8521562976144545 1.3685391503612074 0.8533555979953193 0.38957740071790703 0.24937449867198022 0.4078938819510997 2.7160958064967478 0.10759260388896105 0.27870625459375564 2.0225454207567208e-07 6.694101716557465 -0.5151835523658881 FQTMEEK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQTMEEKK 8 1 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 1 1759400.0 647580.0 522170.0 589650.0 True False 887007.8261914795 499098.8028147227 450386.81422294583 1.0 0.5626768874832697 0.5077596847783846 19.758587308115153 -13.999999999999998 0.2925806576522684 4.823747947010401 0.4931798991672891 0.9996332391131065 0.004217894972283721 16.120985582878276 0.1715903590041023 37.158262963324525 0.020502075179770315 1.0000000000000041e-14 13.999999999999998 -4.330568047843112 FQVDK(ub)VNFHMFDVGGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQVDKVNFHMFDVGGQR 17 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;P38405;P38405-2;A0A590UJQ9;K7EPE2;K7EQ80;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;P63092-3;A0A590UJF0;A0A590UJG5 P63092;P63092-2;P63092-3 GNAS;GNAL Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha 1 49290000.0 2932000.0 8068000.0 38290000.0 True False 3843880.393528392 6864285.848817678 34328118.103615366 1.0 1.7857698851333879 8.930589557731983 21.874132015126772 -6.927795432731704 0.7646740684024897 0.8820020733121683 10.318286843205795 0.9960869153343231 0.22317992248960783 0.09379873855578288 0.08340804489596063 0.20072259197917347 0.6544944856610284 1.1808767372229816e-07 6.927795432731704 9.436284769893627 up FQVDK(ub)VNFHMFDVGGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQVDKVNFHMFDVGGQR 17 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;P38405;P38405-2;A0A590UJQ9;K7EPE2;K7EQ80;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;P63092-3;A0A590UJF0;A0A590UJG5 P63092;P63092-2;P63092-3 GNAS;GNAL Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha 1 148403600.0 11697100.0 17235500.0 119471000.0 True False 11325781.963168815 24117725.031945154 88177961.04682581 1.0 2.1294534108439884 7.785595849679831 23.43310732555944 -6.939770209499591 0.6616978592969964 0.9362548817160213 9.300621652790106 0.9981336473364926 0.1282462990832743 0.08787162299230393 0.055088235355549665 0.1246218390549005 0.48730782666429134 1.1487612843101137e-07 6.939770209499591 8.364366771074085 FQVDK(ub)VNFHMFDVGGQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQVDKVNFHMFDVGGQR 17 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;P38405;P38405-2;A0A590UJQ9;K7EPE2;K7EQ80;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;P63092-3;A0A590UJF0;A0A590UJG5 P63092;P63092-2;P63092-3 GNAS;GNAL Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha 1 323254200.0 19644200.0 180768000.0 122842000.0 True False 29801687.583389144 148508538.05316958 98562224.85643877 1.0 4.9832257867150185 3.3072699182101135 24.828890692860423 -9.44343752449699 10.44585877079987 1.000000000005022 4.145247852693021 0.824436615926492 0.6842061182100074 0.0 0.0 0.662479725300145 0.22082657510004827 3.6021556553620305e-10 9.44343752449699 3.1452478526879997 FQVDK(ub)VNFHMFDVGGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQVDKVNFHMFDVGGQR 17 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;P38405;P38405-2;A0A590UJQ9;K7EPE2;K7EQ80;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;P63092-3;A0A590UJF0;A0A590UJG5 P63092;P63092-2;P63092-3 GNAS;GNAL Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha 1 93274400.0 2932000.0 8642400.0 81700000.0 True False 4016039.6343207285 8260550.19140501 62404142.664317116 1.0 2.056889608561395 15.53872679219017 21.937342076649664 -6.922531108451687 0.8057293862633458 0.7287801072037203 17.844629973138193 0.9948555710456847 0.47471616859322635 0.09670569902693975 0.09806384434075369 0.4145952177903123 1.2736262149085738 1.1952779050217017e-07 6.922531108451687 17.11584986593447 up FQVDK(ub)VNFHMFDVGGQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQVDKVNFHMFDVGGQR 17 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;P38405;P38405-2;A0A590UJQ9;K7EPE2;K7EQ80;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;P63092-3;A0A590UJF0;A0A590UJG5 P63092;P63092-2;P63092-3 GNAS;GNAL Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha 1 111042400.0 11697100.0 16530300.0 82815000.0 True False 9726656.919391679 16441247.992892347 100131233.60670319 1.0 1.6903287665173052 10.294516855742616 23.213512600993717 -6.922855386032794 0.8032798275553082 0.8289698640469616 11.777360266987108 0.9949376862874615 0.30083389983576786 0.09652089759649497 0.09712570673989837 0.26319732603133933 0.8112530598433602 1.194385751947429e-07 6.922855386032794 10.948390402940147 up FQVDK(ub)VNFHMFDVGGQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQVDKVNFHMFDVGGQR 17 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;P38405;P38405-2;A0A590UJQ9;K7EPE2;K7EQ80;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;P63092-3;A0A590UJF0;A0A590UJG5 P63092;P63092-2;P63092-3 GNAS;GNAL Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha 1 227737200.0 19644200.0 126884000.0 81209000.0 True False 25429804.145072762 119822793.85999984 66429795.27470606 1.0 4.711903920943745 2.6122810421871607 24.600017014952872 -10.128206316911106 7.20224356770234 0.9999985992756221 3.6620924815654528 0.6818727289395154 0.8571674508711907 1.9278199209011487e-05 2.3387359484831418e-06 0.8299492602988993 0.276649605177932 7.443782638871177e-11 10.128206316911106 2.6620938822898306 FQVTLCFGEEFPDPQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQVTLCFGEEFPDPQR 16 0 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 0 31032200.0 11258000.0 9900500.0 9873700.0 False True 17079209.07004582 8133678.422040429 7922158.8672035625 1.0 0.47623273353480927 0.46384811115742774 24.0257378302037 FQVVINGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQVVINGR 8 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 54939000.0 17848000.0 12376000.0 24715000.0 False True 17281425.009501267 17317801.33998742 18241400.065892972 1.0 1.0021049381324834 1.0555495311216474 24.042718849848132 -6.915204196007712 0.8595288418640625 0.9986049458002483 1.0632844485378241 0.9927419064373636 0.0021898756144744977 0.10107681267662547 0.12083992058992615 0.001840354620767519 0.005283592668101706 1.2156143103226392e-07 6.915204196007712 0.06467950273757583 FQVVINGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQVVINGR 8 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 71987000.0 20720000.0 25632000.0 25635000.0 False True 31433754.834904023 21057769.336269934 20568231.01378036 1.0 0.6699094475626374 0.6543357967194364 24.9058112799098 FQVVINGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQVVINGR 8 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 83346000.0 20720000.0 37776000.0 24850000.0 False True 26822448.45226104 35673732.39222721 20327554.982532073 1.0 1.3299953751694147 0.7578560554869304 24.676937602002248 -6.750265676147991 1.6485533348089412 1.193969557260379 0.7566722783017383 0.6502944642162776 0.13866834559379143 0.2995538068910724 1.6017813457410164 0.06644133268311718 0.1612761151331867 1.7771918946197593e-07 6.750265676147991 -0.4372972789586407 FQVYVEVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQVYVEVSK 9 0 Q13287 Q13287 NMI N-myc-interactor 0 23355800.0 6661800.0 7897300.0 8796700.0 False True 10106437.642816776 6487965.113113466 7058028.389269417 1.0 0.6419636020536706 0.6983695579704053 23.268771224191052 -10.461808731494532 6.071927629578241 1.0001780066490296 0.6701665800120571 0.9785365779015422 0.023027635074987094 5.5519499702675046e-05 4.921013076224487e-06 0.022308306075508433 0.007432137262330547 3.452957782610729e-11 10.461808731494532 -0.33001142663697247 FQVYVEVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQVYVEVSK 9 0 Q13287 Q13287 NMI N-myc-interactor 0 21355200.0 6661800.0 8042400.0 6651000.0 False True 8623831.423710067 7594833.370162221 5440586.245022965 1.0 0.8806797114889382 0.6308780839644897 23.039897546283502 -6.959140998441848 0.44737519053594094 1.0082752337421101 0.4934229154678684 0.9997370012291767 0.0024941997373545527 0.0800094029444509 0.02227591999191356 0.0033261001014705705 0.020671056063461864 1.0986490931101544e-07 6.959140998441848 -0.5148523182742417 FQWDLNAWTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FQWDLNAWTK 10 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 8163300.0 2400000.0 3159800.0 2603500.0 False True 3146423.241633058 2688370.156803928 2334114.7945354586 1.0 0.8544210204246422 0.741831157248891 21.58528131748884 -6.9739940538054 0.1314825581686225 1.1706318817319554 0.4227030697782317 0.9999991784295712 9.561785795440368e-05 0.07502674842508324 0.00395221152792911 0.006969758635411924 0.015268071665984857 1.0617100936293491e-07 6.9739940538054 -0.7479288119537237 FQWDLNAWTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQWDLNAWTK 10 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 19926600.0 6856900.0 4206800.0 8862900.0 False True 6639231.462777296 5886597.178172184 6541440.608699292 1.0 0.8866383422803167 0.985270756920245 22.66258481857543 -10.147059852293138 4.96744282381846 1.0000037115632705 0.9359545496001177 0.359869205731016 0.04026651466163861 1.6552188273272406e-06 2.842323623372849e-07 0.038990144602791474 0.012995961724447839 7.127547950569147e-11 10.147059852293138 -0.0640491619631528 FQWDLNAWTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQWDLNAWTK 10 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 58571000.0 12527000.0 28389000.0 17655000.0 False True 19004374.846372727 23322761.14573058 14165481.511538623 1.0 1.2272311683108104 0.7453800309691492 24.179828232380533 -6.778466925668165 1.5418323521925472 1.1289198305839547 0.741744029345428 0.7619338448571069 0.09603285145934054 0.25296247294000446 1.1876835691565937 0.049062166032135354 0.11591591658615194 1.665455658168434e-07 6.778466925668165 -0.3871758012385267 FQWDLNAWTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQWDLNAWTK 10 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 10821200.0 2400000.0 2917400.0 5503800.0 False True 3287344.8575613005 2788499.6214483203 4203915.794319085 1.0 0.848252843030577 1.2788180055553215 21.64849137901173 -6.811467894886475 1.408421934258083 0.9174409581028993 1.2866008379778158 0.8636008810130853 0.06585423479404505 0.2048119275829965 0.8004629087435516 0.036763150895618255 0.0849828549115146 1.543590528659781e-07 6.811467894886475 0.3691598798749165 FQWDLNAWTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQWDLNAWTK 10 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 15117400.0 6856900.0 4350200.0 3910300.0 False True 5701816.162174972 4326764.609152909 4727925.650815574 1.0 0.75883972511356 0.8291964378262409 22.442990094009705 -10.002763406878367 6.5422613450838165 1.0000000616093578 0.7940180814698986 0.919539189075942 0.02872300768761571 2.5810949135337332e-08 3.927351055360608e-09 0.027810940895059266 0.009270310868925958 9.936572214013023e-11 10.002763406878367 -0.20598198013945923 FQWDLNAWTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQWDLNAWTK 10 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 65717000.0 12527000.0 29046000.0 24144000.0 False True 16216448.444086595 27429564.566513963 19750039.73836031 1.0 1.69146559193214 1.2179016759716126 23.950954554472982 -10.660245707935315 5.475315405991521 0.9937274165697413 1.4546836339509004 0.5513958319826255 0.1933316591162585 0.014914138622382741 0.0009254515225607812 0.18859297876921843 0.06239752467099311 2.1865242185035412e-11 10.660245707935315 0.4609562173811591 FQWDLNAWTK(ub)SAEAFGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FQWDLNAWTKSAEAFGK 17 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 18050100.0 10445000.0 2709200.0 4895900.0 True False 10113429.192303944 3790997.6882913606 3613516.9161483115 1.0 0.3748478993827545 0.3572988792859798 23.269768923558463 FQWDLNAWTK(ub)SAEAFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQWDLNAWTKSAEAFGK 17 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 94160000.0 21348000.0 22682000.0 50130000.0 True False 32386476.747853886 18634219.884725127 40221783.52724043 1.0 0.5753703939394994 1.241931434542529 24.9488881933242 -6.734639196968045 1.7067180786383194 0.7457849675471805 1.2418533821964284 0.580480585371338 0.17844777704339845 0.32759823537807486 1.8715510330159444 0.08279489207457706 0.20434808518953707 1.8423019128702623e-07 6.734639196968045 0.4960684146492479 FQWDLNAWTK(ub)SAEAFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FQWDLNAWTKSAEAFGK 17 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 21263500.0 10445000.0 6150000.0 4668500.0 True False 8685480.291956661 6116868.72932058 5644661.76529487 1.0 0.7042637279351392 0.6498963299153654 23.05017419899274 -13.999999999999998 0.23819491284821348 2.940510471832141 0.6254425167385037 0.9995220134725104 0.0033632863467110458 13.560410821966283 0.15447916761843386 12.503436293389338 0.026850699094674652 1.0000000000000041e-14 13.999999999999998 -2.3150679550936375 FQWDLNAWTK(ub)SAEAFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQWDLNAWTKSAEAFGK 17 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 108906100.0 21348000.0 22666000.0 64892100.0 True False 27635406.831991795 21404617.1749847 53082403.64917382 1.0 0.7745359894686227 1.920811369699961 24.72001451541665 -6.855649572921962 1.2076326858920186 0.8788320117563536 1.9718488964224188 0.9481127213490211 0.1129452551808317 0.15135540355949623 0.4219554531333088 0.0730661267264598 0.1697954400735826 1.3942813783253504e-07 6.855649572921962 1.0930168846660653 FQYCVAVGAQTFPSVSAPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQYCVAVGAQTFPSVSAPSK 20 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 45905000.0 12474000.0 18128000.0 15303000.0 False True 18923969.971553706 14892916.76528952 12278355.342456838 1.0 0.7869869159418654 0.6488255562080008 24.173711440915408 -9.050542121221278 0.07182242076760262 1.7239074298378072 0.0005565977903719048 0.9999897458589008 0.0004625161324770304 0.5217864421691234 0.023453836255420586 0.3114422623551914 0.24129620993849998 8.901391012827346e-10 9.050542121221278 -1.7233508320474353 FQYCVAVGAQTFPSVSAPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FQYCVAVGAQTFPSVSAPSK 20 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 6100500.0 2003000.0 0.0 4097500.0 False True 2743563.2290397077 0.0 3129754.890661442 1.0 0.0 1.1407628071166809 21.38761939432856 -10.692206387501367 4.432602864294503 1.0185676193238247 0.5703814035582775 0.15903480972150874 0.46571446583035575 0.08605121737585693 0.00597526879726171 0.45407329344871306 0.1503086975207077 2.0313914139706107e-11 10.692206387501367 -0.4481862157655472 FQYCVAVGAQTFPSVSAPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQYCVAVGAQTFPSVSAPSK 20 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 35869000.0 12474000.0 13221000.0 10174000.0 False True 16147838.899300396 12485239.727806967 8322436.39405557 1.0 0.7731833222802271 0.5153901055091736 23.944837763007857 -6.9694579810688415 0.2708185052617336 1.063453016202092 0.21736187723986447 0.9999778404716987 0.0009319317660391461 0.07647896453898978 0.009657756685528384 0.00502813215837117 0.023949297017678273 1.0728574440941182e-07 6.9694579810688415 -0.8460911389622277 FQYCVAVGAQTFPSVSAPSKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FQYCVAVGAQTFPSVSAPSKK 21 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 153042000.0 35045000.0 49939000.0 68058000.0 False True 53165827.13268404 41026995.27481209 54606306.46911886 1.0 0.7716798080169522 1.027094083062789 25.663995901156422 -6.671046959880537 1.933951503557082 0.8543905124948935 1.0260590283712314 0.2835220816270938 0.09696305637706686 0.4587466010307565 3.308964364936383 0.04035161246360804 0.1076510505975506 2.1328142813445222e-07 6.671046959880537 0.1716685158763379 FQYCVAVGAQTFPSVSAPSKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FQYCVAVGAQTFPSVSAPSKK 21 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 123844000.0 35045000.0 44745000.0 44054000.0 False True 45366443.34022634 42254901.415983856 36036624.03221199 1.0 0.9314131394231762 0.794345365845737 25.43512222324887 -6.960059943463609 0.4345882446817841 1.0051868685006151 0.7152752952637463 0.999772411446284 0.001289777786563896 0.07967970994949088 0.021052248963516377 0.001795765713465674 0.011369269660252531 1.0963268652655567e-07 6.960059943463609 -0.2899115732368688 FRGDAGLGK(ub)LIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FRGDAGLGKLIK 12 2 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18;H3BVE6 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 7155000.0 1474100.0 2760600.0 2920300.0 True False 1427305.5023815439 3862921.9763388233 2155385.8228778993 1.0 2.7064436940047587 1.5101082559280479 20.444862733569142 -10.501309071243698 5.361468625991822 0.9976508365772921 2.108275974964463 0.53364089214283 0.488401897416175 0.013732397853456901 0.0012773025008254299 0.4734939195611879 0.157631034579076 3.152760122587782e-11 10.501309071243698 1.1106251383871708 FRGDAGLGK(ub)LIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FRGDAGLGKLIK 12 2 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18;H3BVE6 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 6690400.0 2450200.0 1611000.0 2629200.0 True False 3356105.154165294 1539820.6931354105 2008237.11007372 1.0 0.45881181381469066 0.5983832501735763 21.67835648862281 -10.29114914735061 8.4967605946104 1.0000004471527033 0.5285975319942164 0.938309702182545 0.05697980029110091 4.826633811565433e-07 4.025014510034996e-08 0.05517050700983738 0.01839015146647153 5.115061416496026e-11 10.29114914735061 -0.47140291515848687 FRGDAGLGK(ub)LIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FRGDAGLGKLIK 12 2 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18;H3BVE6 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 6609500.0 1474100.0 3383900.0 1751500.0 True False 1225779.4637025658 3365670.2590484386 2117730.551978999 1.0 2.745738820653888 1.727660329356655 20.22526800900342 -10.129045976872336 5.164437465388391 0.9999607104986638 2.2366995750067358 0.6630108075923433 0.4156288036352278 0.00018802782415737408 3.1709533443818826e-05 0.4024435536863039 0.134143619556212 7.429404818481953e-11 10.129045976872336 1.2367388645080721 FRGDAGLGK(ub)LIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FRGDAGLGKLIK 12 2 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18;H3BVE6 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 14136300.0 2596100.0 2452500.0 9087700.0 True False 3360702.626781607 2316016.2190792356 7433831.847676326 1.0 0.6891464304585555 2.2119873946703135 21.680331460126034 -6.853535993296306 1.2179361599483636 0.8334759066686708 2.2771353354935377 0.9452900383777123 0.15366835122107542 0.15361095856370385 0.4367129829625204 0.0986324520182729 0.22881398081625923 1.401083461654801e-07 6.853535993296306 1.443659428824867 up FRLNLYELK(ub)EGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FRLNLYELKEGR 12 2 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 22757100.0 7533200.0 4179900.0 11044000.0 True False 11428415.150690105 3433964.187292238 8861148.559242837 1.0 0.3004759751910901 0.7753611014653906 23.446122014153165 -10.556325106754882 5.860523494935662 1.001160249551868 0.5379185383290576 0.557992482407855 0.19387104096819907 0.002945674425908978 0.00022300445965239675 0.18813984517706528 0.06257160941514417 2.7776331920684603e-11 10.556325106754882 -0.46324171122281055 FRLNLYELK(ub)EGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FRLNLYELKEGR 12 2 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 40450900.0 7533200.0 26376600.0 6541100.0 True False 9751875.90157205 24908719.023105167 5350686.917353737 1.0 2.5542489747115997 0.5486828351139271 23.217248336245614 -6.699801821544979 1.831445414639157 1.965303540759734 0.5546444678262559 0.416699550304526 0.6560903235251239 0.3959335246797627 2.5817281354658923 0.28580045226216666 0.7352189532523999 1.9961730063367523e-07 6.699801821544979 -1.410659072933478 FRPLQLETINVTMAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FRPLQLETINVTMAGK 16 1 P46063;F8WA66;F8WD97;F5H2L2 P46063 RECQL ATP-dependent DNA helicase Q1 0 5972800.0 1577200.0 2004500.0 2391100.0 False True 2067724.4736265242 1705436.4134798006 2143691.909050787 1.0 0.8247890060945515 1.0367396316062485 20.979612527213412 -6.687139476500172 1.8762334415498625 0.8898623644160867 1.0359895760920095 0.35719604716959785 0.0741453166603715 0.4228636897294382 2.88372790593421 0.031638072452974356 0.08269657362036179 2.0552304393476243e-07 6.687139476500172 0.1461272116759228 FRQDLMNIAGTTLSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FRQDLMNIAGTTLSSK 16 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 22026300.0 4540700.0 7543300.0 9942300.0 False True 5952901.672201354 6417869.043553102 8913566.169275915 1.0 1.0781076854541434 1.4973481270319255 22.505161633991047 -6.93823651959528 0.6757717794518666 0.9951197598453684 1.6047699395366535 0.9979236637562169 0.009951000316686507 0.08858042355617163 0.0583431691536275 0.009561717069563144 0.03637245409444963 1.1528252507099163e-07 6.93823651959528 0.6096501796912851 FRQDLMNIAGTTLSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FRQDLMNIAGTTLSSK 16 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 27645400.0 8163400.0 3127000.0 16355000.0 False True 7904257.335419244 4375627.407089579 12071134.860517075 1.0 0.5535785617052528 1.5271687583381062 22.914198486197385 -6.782016331754762 1.527850964539138 0.7478872473231568 1.5353966376596753 0.774509566188205 0.18895655047184143 0.24745615697270346 1.1410467180664852 0.09739285121076428 0.22943774487831703 1.6518996769522982e-07 6.782016331754762 0.7875093903365185 FRQDLMNIAGTTLSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FRQDLMNIAGTTLSSK 16 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 23223000.0 4540700.0 10846000.0 7836300.0 False True 6219519.497803593 10366787.85707429 5985527.333664492 1.0 1.666814914035609 0.9623777746461386 22.56837169551394 -6.6586106975720085 1.9780757825246513 1.429723264792982 0.9653390839830261 0.22957358697723018 0.2840118391137247 0.487771484634825 3.6675054798085647 0.11606698528051235 0.3147438560306897 2.1947714512712223e-07 6.6586106975720085 -0.4643841808099559 FSAIASQLVHAPPMQLGFPSLHSFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSAIASQLVHAPPMQLGFPSLHSFIK 26 0 O95235-2;O95235 O95235-2 KIF20A Kinesin-like protein KIF20A 0 12929000.0 6025000.0 1886700.0 5017300.0 False True 5833739.672918268 2640069.1490105228 3703118.6142263706 1.0 0.4525517587400083 0.6347761164964573 22.47598957760868 -10.102921862181946 5.549262840005137 1.0000047991289118 0.5436639376181208 0.893181986539987 0.0743927825353443 4.417089281867645e-06 7.139280426380262e-07 0.07203125946273178 0.024010167319726994 7.89002061291172e-11 10.102921862181946 -0.456340861510791 FSAIASQLVHAPPMQLGFPSLHSFIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSAIASQLVHAPPMQLGFPSLHSFIK 26 0 O95235-2;O95235 O95235-2 KIF20A Kinesin-like protein KIF20A 0 46614000.0 12073000.0 11160000.0 23381000.0 False True 18315623.65452685 9168410.80652201 18759735.101743642 1.0 0.5005786851410853 1.0242476835948213 24.12657149045455 -10.967093455666276 12.844538645231077 1.0897744920145016 0.7624131843679534 0.21535030521952248 0.21378697338766106 0.09446703010290543 0.00024201571283288725 0.03557890989014693 0.06899944896387496 1.0787145690697017e-11 10.967093455666276 -0.32736130764654825 FSAIASQLVHAPPMQLGFPSLHSFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSAIASQLVHAPPMQLGFPSLHSFIK 26 0 O95235-2;O95235 O95235-2 KIF20A Kinesin-like protein KIF20A 0 17461600.0 6025000.0 5452400.0 5984200.0 False True 5010054.452756239 5423026.838983339 7235468.552185409 1.0 1.0824287221069837 1.444189603209777 22.256394853042956 -6.942750395374641 0.6334641736512594 0.9960519203321833 1.5501792853731589 0.9985023627512782 0.0074659449013842185 0.0865340784211573 0.04906268236047858 0.007429009694541437 0.030778658568415516 1.1409053183975731e-07 6.942750395374641 0.5541273650409756 FSAIASQLVHAPPMQLGFPSLHSFIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSAIASQLVHAPPMQLGFPSLHSFIK 26 0 O95235-2;O95235 O95235-2 KIF20A Kinesin-like protein KIF20A 0 28247000.0 12073000.0 7743200.0 8430800.0 False True 15628736.494408667 7312284.113180167 6896480.907313135 1.0 0.46787429782287315 0.44126925486141627 23.897697812546998 -13.815029032701492 0.42862759461426214 9.99999999978908 0.4406698764663746 0.9998721078664625 0.002910312091193802 26.616392128084865 0.21931456959054382 223.76074069222494 0.0063198742699641835 1.5309851114995667e-14 13.815029032701492 -9.559330123322706 FSALQQAVPTESTDNRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSALQQAVPTESTDNRR 17 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;H7C044 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 7890330.0 2011100.0 751130.0 5128100.0 False True 1947258.7313204848 1051060.126091204 3784896.7702976237 1.0 0.5397639816350721 1.943705122190409 20.893013156306758 -6.818400655555271 1.3788261363714647 0.7515285686242612 1.9733046963382328 0.8806557516554646 0.20187957212254645 0.1955678304328907 0.7310150994792302 0.11506995799135974 0.265331566549408 1.51914540533865e-07 6.818400655555271 1.2217761277139716 FSASGELGNGNIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSASGELGNGNIK 13 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 191507000.0 57679000.0 61428000.0 72400000.0 False True 75617727.56423049 52263181.84446861 64908742.50983941 1.0 0.6911498603297186 0.8583799672465063 26.172221158854377 -10.075027896595683 4.889536822937235 1.000006760062206 0.7747649144016039 0.707491095428554 0.0682714052694389 5.031217373475486e-06 9.517279594692125e-07 0.06610548738586979 0.022034501301622704 8.413410969653404e-11 10.075027896595683 -0.22524184566060212 FSASGELGNGNIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSASGELGNGNIK 13 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 100042700.0 35191000.0 9590700.0 55261000.0 False True 34073880.967579514 13420316.524839783 40786486.305535555 1.0 0.39385934750458557 1.1970014905065534 25.022162941960048 -6.704848499572572 1.8137342215315828 0.6254041268036563 1.194827725821123 0.4405047592671637 0.2556410814303657 0.38554118471608106 2.468981869592627 0.11230851164263653 0.2870951841747973 1.9731109212684438e-07 6.704848499572572 0.5694235990174668 FSASGELGNGNIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSASGELGNGNIK 13 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 177203000.0 57679000.0 54197000.0 65327000.0 False True 79004485.01636596 51802397.33448782 49898108.05179746 1.0 0.6556893235081126 0.6315857642950391 26.23543122037727 -13.999999999999998 0.377595539449445 6.031261414206315 0.6293783981604603 0.999803614098581 0.0023582146229647913 23.733421259765567 0.2001564432205749 96.96847383863863 0.006580408418346847 1.0000000000000041e-14 13.999999999999998 -5.401883016045855 FSAYIK(ub)NSNPALNDNLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSAYIKNSNPALNDNLEK 18 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 52042600.0 18997000.0 28259000.0 4786600.0 True False 24905250.967209708 24042867.352719236 4291328.548309354 1.0 0.9653734220295195 0.17230617567192252 24.569946613159182 -6.916053471860839 0.8534871581409957 1.0201088603895523 0.05534764791275408 0.9930124715183594 0.03195520968367701 0.10054996379159253 0.11805960466441301 0.026971996549425278 0.07798170561130323 1.2132394629678676e-07 6.916053471860839 -0.9647612124767982 down FSAYIK(ub)NSNPALNDNLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSAYIKNSNPALNDNLEK 18 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 86191600.0 44774000.0 33983000.0 7434600.0 True False 43352673.878048524 47552589.11900385 5487255.226780821 1.0 1.0968778823832117 0.12657247491161724 25.36961764201009 -6.882328711287779 1.0666767921868143 1.0621193437450158 0.05464732882126368 0.9755178543902965 0.0682775086149818 0.12558950853420986 0.2599640961654929 0.049198368891447276 0.11971548435222402 1.311207089434568e-07 6.882328711287779 -1.0074720149237522 down FSAYIK(ub)NSNPALNDNLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSAYIKNSNPALNDNLEK 18 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 168764700.0 103011700.0 25961000.0 39792000.0 True False 156276280.06402922 21328056.71578121 31927093.758546863 1.0 0.13647660865131114 0.20429903850709624 27.219523578825452 -10.223556072016649 7.6066280546825356 1.0000010298048967 0.1703878235798209 0.9950124615479171 0.02768839104372953 4.835571069244295e-07 4.9367395714434854e-08 0.02680920249759074 0.008936389782970254 5.976458772956113e-11 10.223556072016649 -0.8296132062250758 FSAYIK(ub)NSNPALNDNLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSAYIKNSNPALNDNLEK 18 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 90315400.0 44774000.0 41024000.0 4517400.0 True False 37231564.824515805 40802995.569373526 5461967.453902331 1.0 1.0959248090079214 0.14670260247309827 25.150022917444367 -6.882012489820141 1.0685417536248678 1.0611894581464132 0.0767890160863466 0.9752715784760909 0.06709328661586891 0.12586099086978103 0.26165665336557264 0.04827838777459596 0.11736692611221726 1.3121621621707124e-07 6.882012489820141 -0.9844004420600666 down FSAYIK(ub)NSNPALNDNLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSAYIKNSNPALNDNLEK 18 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 163093700.0 103011700.0 38317000.0 21765000.0 True False 133350676.31417863 36184625.26664995 17803993.327758953 1.0 0.2713493944447478 0.13351258366183424 26.9906499009179 -13.999999999999998 0.23414435117674046 5.689740554520811 0.06908421467092005 0.9995157254247302 0.008366007395208354 13.42390878508207 0.15318409901899135 29.336439124216053 0.06975008060550188 1.0000000000000041e-14 13.999999999999998 -5.620656339849891 FSCPICEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSCPICEKR 9 1 Q9Y2Y9;A0A087X1K6;H0YK05 Q9Y2Y9 KLF13 Krueppel-like factor 13 1 16988800.0 2774900.0 7994500.0 6219400.0 True False 4209726.172363672 6567819.013686406 4990132.863940148 1.0 1.560153498059641 1.185381818109631 22.00529496351347 -10.337536144641668 5.290148164987332 0.9998833442160859 1.3727676580846546 0.5688004630495068 0.15299989765392713 0.0002105727091940281 2.6369225496635187e-05 0.14818757134714616 0.04938050463208212 4.5968872883265674e-11 10.337536144641668 0.3728843138685687 FSCPICEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSCPICEKR 9 1 Q9Y2Y9;A0A087X1K6;H0YK05 Q9Y2Y9 KLF13 Krueppel-like factor 13 1 10053000.0 3139900.0 1875000.0 5038100.0 True False 4300805.882606972 1792156.3002041574 3848204.5429265136 1.0 0.4167024388270753 0.8947635973269944 22.036175585861265 -10.090373586176423 7.376650432260937 1.0000000671273175 0.6557330180770444 0.4087922646328347 0.19516765069476585 2.1543874273803793e-07 2.672099271777233e-08 0.18897030182096197 0.06299008840493787 8.121316086544434e-11 10.090373586176423 -0.34426704905027306 FSCPICEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSCPICEKR 9 1 Q9Y2Y9;A0A087X1K6;H0YK05 Q9Y2Y9 KLF13 Krueppel-like factor 13 1 14751600.0 2774900.0 7976700.0 4000000.0 True False 3592162.7514565284 7532789.6329171555 3272041.0434659244 1.0 2.097006776728812 0.9108832950676294 21.77642128560592 -6.663730643869848 1.959996258443345 1.703977381129352 0.9158310666609277 0.2513896598902655 0.4666729098801108 0.4756941829114147 3.5168612979627962 0.19212020946217037 0.5174552922179046 2.1690489653183035e-07 6.663730643869848 -0.7881463144684242 FSDAGQPMSFVLEFHFEPNEYFTNEVLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSDAGQPMSFVLEFHFEPNEYFTNEVLTK 29 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;P55209-3;B7Z4K9 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 46047000.0 17163000.0 11343000.0 17541000.0 False True 26037525.783371523 9318753.026736494 14074013.66150657 1.0 0.3578970254035342 0.5405280739268525 24.63408902709095 -10.9100815882296 11.467382007270347 1.0512690486856542 0.4492125496651938 0.9238218132686572 0.07455881334526754 0.03772623028920373 0.00029581964692463805 0.02786810321100735 0.02406375353326738 1.2300376695038075e-11 10.9100815882296 -0.6020564990204604 FSDFLGLYEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSDFLGLYEK 10 0 Q13596;Q13596-2;Q13596-3 Q13596 SNX1 Sorting nexin-1 0 4398310.0 927410.0 2069900.0 1401000.0 False True 1215843.491051215 1761078.9884070044 1256037.9593409535 1.0 1.4484421731652157 1.0330589163700556 20.213526099737 -10.521461802565168 7.003982998207286 0.9998928742612175 1.2407505447676355 0.3093417425140297 0.1695795044739359 0.0002837957165913768 1.939007222217876e-05 0.164267219715687 0.054731549723805006 3.009803878043126e-11 10.521461802565168 0.24085767050641793 FSDFLGLYEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSDFLGLYEK 10 0 Q13596;Q13596-2;Q13596-3 Q13596 SNX1 Sorting nexin-1 0 4042410.0 927410.0 1774900.0 1340100.0 False True 1270298.5393128863 1696479.0491905885 1023595.9802258434 1.0 1.3354963393945383 0.8057916690823826 20.27673616125989 -6.735574048688001 1.7031379592892228 1.2006383061893047 0.8057853589869732 0.584815604260748 0.1409834731902998 0.325880489558823 1.8542947662639875 0.06553712656111219 0.1615954475865145 1.8383404838286196e-07 6.735574048688001 -0.39485294720233144 FSDSYASVIK(ub)ALEHSALAINHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSDSYASVIKALEHSALAINHK 22 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ISY3 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 1 22899000.0 8603400.0 4007100.0 10288500.0 True False 8330289.776263058 5607155.926750443 7593633.201616013 1.0 0.6731045470624427 0.9115689136353782 22.98993525117026 -10.166014912414495 6.18655767064641 1.0000014383442677 0.7923367303489095 0.5027694785114194 0.0973526699899522 1.9313877151343922e-06 2.604197932663437e-07 0.09426197049895109 0.03142043913165879 6.823152650096788e-11 10.166014912414495 -0.2076647079953582 FSDSYASVIK(ub)ALEHSALAINHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSDSYASVIKALEHSALAINHK 22 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ISY3 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 1 44475800.0 22679000.0 9646800.0 12150000.0 True False 34405701.05698788 7925253.169207573 9748547.174465833 1.0 0.23034709149162752 0.2833410416000193 25.03614430487062 -10.11223267342728 7.701162165212443 1.000000108203125 0.25684406654582465 0.9962007240958992 0.021634689536678225 4.019022751454526e-08 4.661203959116493e-09 0.020947700878207843 0.006982566022993551 7.722667320609165e-11 10.11223267342728 -0.7431560416573002 FSDSYASVIK(ub)ALEHSALAINHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSDSYASVIKALEHSALAINHK 22 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ISY3 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 1 23125500.0 8603400.0 10929700.0 3592400.0 True False 7154108.295243642 10870819.536724411 4343554.2306191055 1.0 1.5195212440314605 0.6071412468702615 22.770340526604535 -6.752267164695043 1.6416636967585874 1.304649716509938 0.6050321312550324 0.6586023304560981 0.21833379076538437 0.2960983940854359 1.5707750916472993 0.10503551909466931 0.2543728588929133 1.7690203762389393e-07 6.752267164695043 -0.6996175852549056 FSDSYASVIK(ub)ALEHSALAINHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSDSYASVIKALEHSALAINHK 22 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ISY3 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 1 45648100.0 22679000.0 7311100.0 15658000.0 True False 29358412.569924165 6904230.85802659 12808404.664647374 1.0 0.23517044191617967 0.43627715341015316 24.80727062696307 -10.640549832452047 7.310975480846607 1.0015646504616038 0.3357237976659413 0.9356802332173626 0.082101471168224 0.00209732370603129 0.00010311639361513939 0.07962629938583093 0.026498135877805005 2.287969167011251e-11 10.640549832452047 -0.6658408527956625 FSDVK(ub)IYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSDVKIYK 8 1 Q92989;Q92989-2;E9PL17 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 3608080.0 577640.0 609340.0 2421100.0 True False 559303.1343841496 852652.6396661209 1786941.2785568864 1.0 1.524491080503204 3.194942364348616 19.093270889773354 -6.950098744386081 0.5577573694566227 0.9778908979345974 3.821069535645806 0.9992090176884119 0.02632178463812953 0.0834460967748265 0.03579829187422612 0.028292490219191703 0.13879312738340643 1.1217633729374642e-07 6.950098744386081 2.8431786377112087 FSDVK(ub)IYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSDVKIYK 8 1 Q92989;Q92989-2;E9PL17 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 3006140.0 577640.0 1056600.0 1371900.0 True False 480333.2537908893 1050907.886081321 1658757.947051092 1.0 2.1878724360375608 3.4533481368608805 18.87367616520763 -6.97032180525915 0.250381292150245 0.6002763348042615 5.078026278101484 0.9999847848051375 0.003907457390814543 0.07619843031276802 0.008655753927095628 0.02815203841919585 0.12120839719819612 1.0707256206747925e-07 6.97032180525915 4.477749943297223 FSDVK(ub)IYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSDVKIYK 8 1 Q92989;Q92989-2;E9PL17 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 10346500.0 1523000.0 1756100.0 7067400.0 True False 1971553.522818227 1658371.491264036 5781205.717647776 1.0 0.8411496173299344 2.9323098007422397 20.910901445915627 -6.888580698501897 1.0307712885278502 0.8837860586136856 3.107226895446484 0.9799731184482826 0.13451918949816702 0.12030109997528046 0.22864937288770001 0.09961942126658377 0.24711048340492425 1.292466518610069e-07 6.888580698501897 2.2234408368327983 up FSEECLSSLGK(ub)ALGNIAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSEECLSSLGKALGNIAR 18 1 D6RA96;Q9NZ71-8;Q9NZ71-4;Q9NZ71;Q9NZ71-6;Q9NZ71-2;Q9NZ71-7;Q9NZ71-9 D6RA96 RTEL1-TNFRSF6B;RTEL1 Regulator of telomere elongation helicase 1 1 18370700.0 4891500.0 1960200.0 11519000.0 True False 6332143.175880065 1851113.1468457163 9422660.194920994 1.0 0.2923359588419985 1.4880680889865376 22.594262445897954 -6.746377289330176 1.663563892225776 0.5820820822614342 1.4897617305813213 0.6331487611809299 0.2973246439469633 0.30638567211297774 1.6671343140439534 0.14126701792211105 0.3442309279231251 1.7931751455844943e-07 6.746377289330176 0.9076796483198871 FSEGNILELLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSEGNILELLHR 12 0 Q9BPX3 Q9BPX3 NCAPG Condensin complex subunit 3 0 2024420.0 416640.0 1050600.0 557180.0 False True 546219.0747474995 893854.5752067241 499528.3584479607 1.0 1.6364396933957788 0.9145201651532903 19.05912017038387 -6.673957440933106 1.9235347870655528 1.4048471466289016 0.9173929664420145 0.29665484579160284 0.27010159931030164 0.45206721578424514 3.228411837477974 0.11290044908079234 0.30007285108303555 2.118568736069131e-07 6.673957440933106 -0.48745418018688713 FSEGNILELLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSEGNILELLHR 12 0 Q9BPX3 Q9BPX3 NCAPG Condensin complex subunit 3 0 4830440.0 416640.0 1633400.0 2780400.0 False True 570683.0672726425 1561230.987068518 2123726.7841354674 1.0 2.7357233403293595 3.7213769006411783 19.122330231906762 -8.70914493277505 0.2369670979338045 1.911945936020255e-20 4.531752645075892 0.999363860695585 0.028373923623658044 0.27346027169392406 0.07033052991734606 0.6358215220094907 0.42003241734727703 1.9536873623341187e-09 8.70914493277505 4.531752645075892 FSELQK(ub)AMGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSELQKAMGPK 11 1 P30154;P30154-2;P30154-4;P30154-3;P30154-5 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 8425800.0 2813700.0 1360600.0 4251500.0 True False 3854000.927383432 1300484.1930974799 3247383.2623909977 1.0 0.33743743647213076 0.8426005399525732 21.877925488111757 -9.998058971223498 6.824485682661565 1.0000000595705412 0.5900189882125133 0.46758080891701725 0.20623197340131402 1.8689850052631443e-07 2.746834469661311e-08 0.19968327638912753 0.06656108320323113 1.0044793865184404e-10 9.998058971223498 -0.40998107135802786 FSELQK(ub)AMGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FSELQKAMGPK 11 1 P30154;P30154-2;P30154-4;P30154-3;P30154-5 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 18466180.0 2412180.0 5394700.0 10659300.0 True False 2005834.5476928675 5365637.680335886 12888110.346965302 1.0 2.675015088611122 6.425310782381999 20.935771178730267 -6.957778952151728 0.46568072884321615 0.8966711784404687 8.356285314161937 0.999678748494797 0.04065485459745591 0.08050426474239895 0.024136614325219054 0.05144299228326531 0.3096389229338505 1.1021001153575397e-07 6.957778952151728 7.459614135721468 FSELQK(ub)AMGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FSELQKAMGPK 11 1 P30154;P30154-2;P30154-4;P30154-3;P30154-5 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 86789200.0 8866800.0 10397400.0 67525000.0 True False 11478247.390758136 9818775.549950836 55236142.865009084 1.0 0.8554246319744384 4.812245370271702 23.452399038482245 -6.898419636256232 0.9712159687766801 0.8282805489248392 5.2144878884259915 0.9857631900327706 0.2186071612528127 0.11257753451954122 0.1840580991804417 0.16930692078132922 0.4371114551063839 1.2635148884783108e-07 6.898419636256232 4.386207339501152 up FSFDLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSFDLGK 7 0 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 5725200.0 1164500.0 1392900.0 3167800.0 False True 1526670.7770340417 1185084.7494816761 2840026.443683278 1.0 0.7762542961515344 1.8602743213574664 20.541957551203826 -6.852893791043724 1.221098975103745 0.8802416428530933 1.9060759622581316 0.9444038129796561 0.11018140943495758 0.1543035196796148 0.4413053494621239 0.07055105339612677 0.16358486691278645 1.4031568118437938e-07 6.852893791043724 1.0258343194050383 FSFDLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSFDLGK 7 0 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 4512700.0 1164500.0 1237900.0 2110300.0 False True 1595047.1194292244 1183205.48481212 1611890.6029927589 1.0 0.7417997063532024 1.0105598658236263 20.605167612726717 -11.061229075957966 11.029812103194658 1.5863227599808158 0.8761797860884143 0.2205789978041841 0.1097208756485958 0.04224699523398858 0.0002345233107025488 0.0028371079755475782 0.035412260343192205 8.685022022950359e-12 11.061229075957966 -0.7101429738924016 FSFITHLQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSFITHLQDK 10 0 Q68CP9-3;Q68CP9;F8WCU9;F8VWP4;F8W108 Q68CP9-3 ARID2 AT-rich interactive domain-containing protein 2 0 5408500.0 1991600.0 1440200.0 1976700.0 False True 2611006.886681837 1225327.7738556298 1772170.0458452986 1.0 0.4692931987677831 0.6787305138430474 21.316174832171647 -10.19473348527513 5.419797446044661 1.0000184084029353 0.5740118563053532 0.8465320264809201 0.08550242583903955 1.9019430703659744e-05 2.825858333942793e-06 0.08279094098617922 0.02759578927787921 6.386552913598304e-11 10.19473348527513 -0.4260065520975821 FSFITHLQDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSFITHLQDK 10 0 Q68CP9-3;Q68CP9;F8WCU9;F8VWP4;F8W108 Q68CP9-3 ARID2 AT-rich interactive domain-containing protein 2 0 5634020.0 2267600.0 691620.0 2674800.0 False True 2195616.2792214826 967787.4727506533 1974189.6377200314 1.0 0.4407816984732002 0.8991505739882908 21.066194510536054 -10.059817498366446 7.282657486314474 1.0000000469387342 0.6699661362307504 0.40871599515754087 0.1871283098308791 1.425114566627196e-07 1.853640374909294e-08 0.1811862311935864 0.0603954022982447 8.713296680140351e-11 10.059817498366446 -0.3300339107079838 FSFITHLQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSFITHLQDK 10 0 Q68CP9-3;Q68CP9;F8WCU9;F8VWP4;F8W108 Q68CP9-3 ARID2 AT-rich interactive domain-containing protein 2 0 6731700.0 1991600.0 2507400.0 2232700.0 False True 2727948.3409662903 2396614.777137015 1705382.24389989 1.0 0.8785411150007661 0.6251519569816383 21.37938489369454 -6.959210961526515 0.44641421502822987 1.008477474353956 0.4852303493062591 0.9997398071317016 0.00251890778699902 0.07998418446077421 0.022181842238926434 0.003369281889097237 0.020971171723018465 1.0984721194396495e-07 6.959210961526515 -0.5232471250476969 FSFLSK(ub)PVDENHQQDGDEDSLVSHFYTNPIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSFLSKPVDENHQQDGDEDSLVSHFYTNPIAK 32 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 31681100.0 9485500.0 16021100.0 6174500.0 True False 12435582.35771266 13630814.329758683 5535621.969986236 1.0 1.0961138720861536 0.4451437665525164 23.567970734686448 -6.869352200256751 1.1374462176631923 1.0541570733244094 0.40747464479711626 0.9640360495446508 0.0544104218496585 0.13748125267219774 0.33283385462811294 0.037137034674172856 0.08783057502239912 1.350976515964594e-07 6.869352200256751 -0.6466824285272932 down FSFLSK(ub)PVDENHQQDGDEDSLVSHFYTNPIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSFLSKPVDENHQQDGDEDSLVSHFYTNPIAK 32 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 303351000.0 145975000.0 82050000.0 75326000.0 True False 141341103.5276752 114812992.88509741 55595860.868438326 1.0 0.8123114226472452 0.39334531485069674 27.074605837171198 -6.957840771344756 0.46486563120189406 1.0116364700243687 0.17699240996109347 0.9996815440900352 0.004525466700592165 0.08048163982659141 0.024050919641530426 0.005738564331216281 0.03459397636934452 1.101943249235997e-07 6.957840771344756 -0.8346440600632753 down FSFLSK(ub)PVDENHQQDGDEDSLVSHFYTNPIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSFLSKPVDENHQQDGDEDSLVSHFYTNPIAK 32 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 325922000.0 120642000.0 129951000.0 75329000.0 True False 183022734.11160713 106760228.73820278 60440190.132126406 1.0 0.5833167625673238 0.33023323810292343 27.447447622651765 -8.735930605701583 0.18126975171474297 1.388127644786192 6.201631800583066e-09 0.9997517319029843 0.004350952442698833 0.28195076165937416 0.05198479588101943 0.20295543694883245 0.1419381703005956 1.8368318204191138e-09 8.735930605701583 -1.3881276385845602 down FSFLSK(ub)PVDENHQQDGDEDSLVSHFYTNPIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSFLSKPVDENHQQDGDEDSLVSHFYTNPIAK 32 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 40084500.0 9485500.0 16288500.0 14310500.0 True False 12992545.685999054 15568820.211133543 10930654.633998899 1.0 1.1982886639306352 0.8413019971734964 23.63118079620934 -6.755943918526913 1.6277990000078848 1.1157557272364507 0.8402552032519823 0.6741816502926544 0.08335901516236695 0.28977865506505474 1.5123498011144392 0.040424330387949736 0.0975367482552486 1.7541069992007596e-07 6.755943918526913 -0.27550052398446834 FSFLSK(ub)PVDENHQQDGDEDSLVSHFYTNPIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSFLSKPVDENHQQDGDEDSLVSHFYTNPIAK 32 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 238288900.0 145975000.0 73785000.0 18528900.0 True False 121384680.2889778 73387505.55982417 22403207.322046056 1.0 0.6045862244322114 0.1845637132190919 26.855011112605474 -7.607893035903207 0.3861553673941944 1.047203784384907 2.3322615864874038e-23 0.9987843594750382 0.011608680316809039 0.12163186086036293 0.053595244341976746 0.024321596921713536 0.0720007113471549 2.4666467825679605e-08 7.607893035903207 -1.047203784384907 down FSFLSK(ub)PVDENHQQDGDEDSLVSHFYTNPIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSFLSKPVDENHQQDGDEDSLVSHFYTNPIAK 32 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 310390000.0 120642000.0 118256000.0 71492000.0 True False 156173447.2093477 111674949.64462136 58481189.56986651 1.0 0.7150700175998747 0.37446307688574954 27.218573944744215 -6.968754424075534 0.28637681373423163 1.0695032984974928 0.009559294693938061 0.9999709713690758 0.001377715229486331 0.07670897190866863 0.010469708518355964 0.006069161913871709 0.0310196022559371 1.0745968815508986e-07 6.968754424075534 -1.0599440038035548 down FSFLSK(ub)PVDENHQQDGDEDSLVSHFYTNPIAK(ub)PIPQTPESAGNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNK 44 2 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 2 47758600.0 11952000.0 8359600.0 27447000.0 True False 18132057.80824196 6867764.066147082 22022088.419552557 1.0 0.37876363172774175 1.2145388379217705 24.11203933012512 -6.707625368178027 1.8033393792475456 0.6171673572261022 1.212471049727683 0.4539966344695161 0.2618835260699981 0.37985357936271325 2.406419789043034 0.11562299217609454 0.29462201267283433 1.9605351443412162e-07 6.707625368178027 0.5953036925015808 FSFLSK(ub)PVDENHQQDGDEDSLVSHFYTNPIAK(ub)PIPQTPESAGNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNK 44 2 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 2 83491000.0 11952000.0 52972000.0 18567000.0 True False 15472099.609142106 50024061.63386962 15187996.51350795 1.0 3.233178618130894 0.9816377154483747 23.88316565221757 -6.648016963374504 2.0153444981367863 2.451336198306388 0.9910264990885161 0.18620641409085392 0.9536018530639324 0.5133634041821215 3.994238705139948 0.38402228075784056 1.0563236700519179 2.248966760348294e-07 6.648016963374504 -1.4603096992178721 FSFLSK(ub)PVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNK 44 2 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 141409000.0 44307000.0 38207000.0 58895000.0 True False 67216958.27558362 31388662.337346483 47254377.43540445 1.0 0.46697534584435857 0.7030127314250915 26.002321923013064 -10.341008200063262 5.842229433969298 1.0000586236756552 0.5849940386347259 0.8047557421919762 0.09636185914889746 7.359015392097578e-05 8.300903230523048e-06 0.09331508937383162 0.031100656307771538 4.5602830544295876e-11 10.341008200063262 -0.41506458504092936 FSFLSK(ub)PVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNK 44 2 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 256771000.0 44307000.0 137115000.0 75349000.0 True False 57356284.92154103 129484429.71622816 61636255.14602846 1.0 2.257545618468017 1.0746207713826323 25.773448245105513 -6.631756933345785 2.0741328835266164 1.8274265744823963 1.0794137348229262 0.12385209762082372 0.539180536941864 0.5544266014700194 4.547656155220264 0.21244980055408122 0.5972181541039397 2.3347644214887799e-07 6.631756933345785 -0.7480128396594701 FSFLSKPVDENHQQDGDEDSLVSHFYTNPIAK(ub)PIPQTPESAGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSFLSKPVDENHQQDGDEDSLVSHFYTNPIAKPIPQTPESAGNK 44 2 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 50026200.0 30576000.0 7730800.0 11719400.0 True False 29605381.616456248 10817748.755589424 8649737.565536166 1.0 0.3653980514669787 0.29216774428363324 24.81935611458145 -13.999999999999998 0.3047566333307041 6.949787908377337 0.275022080110619 0.9996604150627538 0.005856803824839261 16.904956743715065 0.17546903708871367 63.59460653799487 0.025935180742314268 1.0000000000000041e-14 13.999999999999998 -6.674765828266717 FSFSGNTLVSSSADPEGHFETPIWIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSFSGNTLVSSSADPEGHFETPIWIER 27 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 103740000.0 17744000.0 62737000.0 23259000.0 False True 26918945.2601611 51541092.18358171 18661848.455218147 1.0 1.9146772537132182 0.693260760213993 24.682118547497595 -6.7062267430924765 1.8082512602846164 1.564450741745549 0.6963820967556461 0.4474134586170566 0.3856720018809125 0.38267714280581505 2.436611689068313 0.16986902432277518 0.4335985939660658 1.9668591337535306e-07 6.7062267430924765 -0.868068644989903 FSFTLPYPVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSFTLPYPVK 10 0 H3BPZ1;H3BS72;Q9P035;H3BRL8;Q9P035-2 H3BPZ1 HACD3 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 0 15443700.0 3841100.0 5579400.0 6023200.0 False True 5035719.2972653145 4746975.268330864 5399977.042614153 1.0 0.9426608172756461 1.0723347994290808 22.263766435437095 -6.7865379685966705 1.5104560784181842 0.9678080397548628 1.073579390628132 0.7898086694018528 0.024324863875019077 0.2405545077466583 1.0842925360653497 0.012679485761718803 0.02975832921923146 1.63479022183523e-07 6.7865379685966705 0.10577135087326905 FSFTLPYPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSFTLPYPVK 10 0 H3BPZ1;H3BS72;Q9P035;H3BRL8;Q9P035-2 H3BPZ1 HACD3 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 0 6910200.0 3054300.0 1222100.0 2633800.0 False True 2957342.918339293 1710090.9031673097 1943928.7676936649 1.0 0.5782524889361217 0.657322745914527 21.495870110010493 -10.822918350677998 7.2812928962784165 1.0196300496275104 0.6177876174253244 0.9689002331953284 0.0322802972379723 0.009758638160417402 0.00023733058431730714 0.029651256435873064 0.010418421134440999 1.503424590127829e-11 10.822918350677998 -0.40184243220218596 FSFTLPYPVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSFTLPYPVK 10 0 H3BPZ1;H3BS72;Q9P035;H3BRL8;Q9P035-2 H3BPZ1 HACD3 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 0 11783400.0 3841100.0 2678700.0 5263600.0 False True 5261258.47182447 2560346.1767236665 4020446.0872447956 1.0 0.4866413977634906 0.7641605347419108 22.326976496959986 -10.100408740941816 5.270144056790195 1.0000068012873709 0.625400966252328 0.70839768629807 0.11329671324375 9.054026115492191e-06 1.5453258202612554e-06 0.10970106114412081 0.036566356964235484 7.935809958189458e-11 10.100408740941816 -0.37460583503504286 FSFTLPYPVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSFTLPYPVK 10 0 H3BPZ1;H3BS72;Q9P035;H3BRL8;Q9P035-2 H3BPZ1 HACD3 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 0 5623190.0 3054300.0 833790.0 1735100.0 False True 2539785.778432093 829298.2077756431 2097901.3878040332 1.0 0.3265228960718099 0.8260150937214665 21.27627538544477 -9.944526642082426 6.573341803172107 1.000000048876839 0.5762689948968935 0.48967541288076355 0.20391683579053885 1.4615099284089015e-07 2.3721852071940723e-08 0.19744165079377174 0.06581387575233492 1.1362485916073824e-10 9.944526642082426 -0.4237310539799455 FSFTLPYPVKIK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSFTLPYPVKIK 12 1 H3BPZ1;H3BS72;Q9P035;H3BRL8;Q9P035-2 H3BPZ1 HACD3 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 1 9547800.0 1185000.0 6352400.0 2010400.0 True False 1534005.8598421514 5998883.355791618 1644527.8284459738 1.0 3.9106000262664584 1.0720479442074589 20.548872563213955 -6.640322726582212 2.04301088910614 2.902875262788657 1.0837952136953213 0.1559347445840258 1.245253705339155 0.5325682073113355 4.248709905427294 0.49625755849726016 1.3791427654941228 2.289165928963051e-07 6.640322726582212 -1.8190800490933356 FSGHVSWVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSGHVSWVGK 10 0 C9J7L8;H7C5Q2;Q9Y305-3;Q9Y305-2;Q9Y305;Q9Y305-4 C9J7L8 ACOT9 Acyl-coenzyme A thioesterase 9, mitochondrial 0 9231700.0 3107100.0 2652400.0 3472200.0 False True 4073438.1891991985 2256672.2589742206 3112930.051694258 1.0 0.553996931868963 0.7642021081719745 21.95781558606699 -10.043264740511308 4.945537832437151 1.000006324950776 0.6590995200173116 0.7781115427639359 0.08581590388328679 118799462.20374753 0.11921633361238276 8556.640627283832 0.029377066466826685 9.051806458262346e-11 10.043264740511308 -0.34090680493346437 FSGHVSWVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSGHVSWVGK 10 0 C9J7L8;H7C5Q2;Q9Y305-3;Q9Y305-2;Q9Y305;Q9Y305-4 C9J7L8 ACOT9 Acyl-coenzyme A thioesterase 9, mitochondrial 0 3744230.0 0.0 593530.0 3150700.0 False True 0.0 830529.6242180612 2325437.1510260566 0.0 FSGHVSWVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSGHVSWVGK 10 0 C9J7L8;H7C5Q2;Q9Y305-3;Q9Y305-2;Q9Y305;Q9Y305-4 C9J7L8 ACOT9 Acyl-coenzyme A thioesterase 9, mitochondrial 0 6331200.0 3107100.0 1138700.0 2085400.0 False True 4255878.8362203 1088388.4688226515 1592871.4701611656 1.0 0.2557376538917784 0.37427556832793085 22.02102564758988 -9.959301494644382 5.779404846853176 1.00000066232086 0.3150066111512934 0.9780337008681567 0.04839290092503836 4.129984225673744e-07 7.429853473845305e-08 0.04685627021880284 0.015618741612917956 1.0982431555793184e-10 9.959301494644382 -0.6849940511695665 FSGHVSWVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSGHVSWVGK 10 0 C9J7L8;H7C5Q2;Q9Y305-3;Q9Y305-2;Q9Y305;Q9Y305-4 C9J7L8 ACOT9 Acyl-coenzyme A thioesterase 9, mitochondrial 0 2081750.0 0.0 808950.0 1272800.0 False True 0.0 804592.0257859974 1538936.5952377222 0.0 FSGWYDADLSPAGHEEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSGWYDADLSPAGHEEAK 18 0 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 70197000.0 17587000.0 23729000.0 28881000.0 False True 23056727.312750272 20188725.694917567 25892671.166114252 1.0 0.8756110709499213 1.1229985424599143 24.458684414636807 -6.769985132618508 1.5743800346859267 0.9286536826064616 1.124393816795113 0.7305682288676105 0.05242383210300362 0.2664442605157214 1.3033526188366946 0.02624582535618598 0.06248014448718368 1.6983017901297876e-07 6.769985132618508 0.19574013418865144 FSGWYDADLSPAGHEEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSGWYDADLSPAGHEEAK 18 0 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 60200800.0 19704000.0 7359800.0 33137000.0 False True 19078507.305424303 10298606.520849962 24457425.61130877 1.0 0.5398014821590321 1.2819360141637055 24.185444964102953 -6.739006357822686 1.6904974444566994 0.7258630827746633 1.2822622434016737 0.6003777104456572 0.19336081899039248 0.3196299963082216 1.7931767328025752 0.0905038998671002 0.22231714036784325 1.8238690017257384e-07 6.739006357822686 0.5563991606270104 FSGWYDADLSPAGHEEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSGWYDADLSPAGHEEAK 18 0 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 55573000.0 17587000.0 18722000.0 19264000.0 False True 24089389.170804445 17894800.134625174 14714239.95453375 1.0 0.7428498916158941 0.6108183088497292 24.521894476159698 -13.999999999991978 0.08519887050525604 2.3469567400919646 0.2518372484559087 0.9998643585896004 0.0018820280780461195 12.208055798596323 0.08359835223159022 3.031263453698275 0.32406407282314376 1.0000000000184713e-14 13.999999999991978 -2.095119491636056 FSGWYDADLSPAGHEEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSGWYDADLSPAGHEEAK 18 0 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 37261100.0 19704000.0 10108000.0 7449100.0 False True 16384749.035204787 10053546.197719082 9006672.36925308 1.0 0.6135917111771267 0.5496985245182004 23.96585023953723 -13.999999999999998 0.25324259340355587 3.73182521130265 0.5247890168875045 0.999548877355106 0.004225239674991265 14.128800642344828 0.1592362144680635 19.67249120095068 0.02896400338767012 1.0000000000000041e-14 13.999999999999998 -3.2070361944151458 FSGWYDADLSPAGHEEAKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSGWYDADLSPAGHEEAKR 19 1 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 15878300.0 3579000.0 7498600.0 4800700.0 False True 4692103.659085306 6379838.109313864 4303969.615566113 1.0 1.359696752854256 0.9172793118567083 22.161803455409345 -6.690479954096388 1.864609301028497 1.2254065018657867 0.9187963385994612 0.37268450462004055 0.15211186774769392 0.4156573817323361 2.8022295667295603 0.06525097519621864 0.16982168563088612 2.0394827946568466e-07 6.690479954096388 -0.3066101632663255 FSGWYDADLSPAGHEEAKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSGWYDADLSPAGHEEAKR 19 1 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 43057900.0 2490500.0 38238000.0 2329400.0 False True 3778270.579938633 31414130.14514235 1868993.068987711 1.0 8.314420441971782 0.4946689310478308 21.84929459300847 -6.661150769294529 1.9684937894290258 5.70348491181981 0.5268491382760869 0.24076537855366797 3.11340409184499 0.4816274109855554 3.5887755790984386 1.277192806548818 3.452517509318639 2.1819722887411414e-07 6.661150769294529 -5.176635773543723 FSGWYDADLSPAGHEEAKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSGWYDADLSPAGHEEAKR 19 1 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 12666700.0 3579000.0 3688200.0 5399500.0 False True 4902253.0188382985 3525243.1287535825 4124249.306193152 1.0 0.7191067281119182 0.8412967038511789 22.225013516932236 -10.111810436277336 4.757105917372931 1.0000130861659315 0.7802017159792004 0.8118305126491023 0.049883848715444004 69528147.07334171 0.2667294896760556 9966.256585143472 0.01707656824667531 7.730179234351822e-11 10.111810436277336 -0.21981137018673114 FSGWYDADLSPAGHEEAKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSGWYDADLSPAGHEEAKR 19 1 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 9832500.0 2490500.0 4465300.0 2876700.0 False True 3224001.345094408 4216802.12968583 2353170.117434607 1.0 1.30794056153297 0.7298911711110652 21.62042091510092 -6.7619827166588395 1.6049439374986803 1.178429294205343 0.7275659914502726 0.6990138184728129 0.12956044114324675 0.2796095005030773 1.4199240255998435 0.06367897089848185 0.15273635539448308 1.7298852009859069e-07 6.7619827166588395 -0.45086330275507036 FSHEEIAMATVTALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSHEEIAMATVTALR 15 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BU78;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 39453300.0 8849000.0 16352100.0 14252200.0 False True 11601124.693837907 13912430.419986565 12777519.060755996 1.0 1.1992311769027306 1.1014034757804945 23.467761341251222 -10.40241207300554 4.262812358827309 0.9995738094249406 1.1503173263426645 0.7589192842500527 0.03993799174669552 0.00016222205010138396 2.2741341750197295e-05 0.03877875891540581 0.01288993140916952 3.959022108410999e-11 10.40241207300554 0.15074351691772392 FSHEEIAMATVTALR ddPTM_RPMI8226_Bortezomib_2h_R1 2 FSHEEIAMATVTALR 15 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BU78;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 144291300.0 43426300.0 31784900.0 69080100.0 False True 42047755.87685477 44476776.32606376 50985949.45142192 1.0 1.0577681352679762 1.212572428377496 25.32552546893149 -6.953957154598823 0.5135667584589475 0.9972324708017212 1.2799410291957263 0.9994763480205442 0.0020536817925020513 0.08193459588129363 0.029679331080620992 0.002351132928453066 0.01277966379528701 1.1118414107878762e-07 6.953957154598823 0.2827085583940051 FSHEEIAMATVTALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSHEEIAMATVTALR 15 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BU78;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 201091000.0 12434000.0 173553000.0 15104000.0 False True 18863287.04716201 142581111.17422187 12118687.779681621 1.0 7.5586567080138485 0.6424483574566016 24.16907776087333 -6.6582055125451545 1.9796357234419513 5.228013643086165 0.6715795396475779 0.22788930673725072 2.79374103082423 0.48868670758989347 3.679790891491458 1.141025919344397 3.0956939673221293 2.1968200692864904e-07 6.6582055125451545 -4.556434103438587 FSHEEIAMATVTALR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FSHEEIAMATVTALR 15 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BU78;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 73545900.0 34399000.0 18789400.0 20357500.0 False True 47117239.89802139 17959222.179763205 15549477.775873166 1.0 0.381160318784237 0.3300167371757729 25.48975169357376 -13.999999999999998 0.35325290458743547 8.764828668275682 0.3232520952683289 0.9997608575873238 0.004708779870657817 20.987908244337603 0.1915631018145712 122.47708577208277 0.015091983526482524 1.0000000000000041e-14 13.999999999999998 -8.441576573007353 FSHEEIAMATVTALR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FSHEEIAMATVTALR 15 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BU78;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 86204800.0 43426300.0 17814100.0 24964400.0 False True 36110892.56128262 17718131.907477997 30184340.617656045 1.0 0.4906589300557756 0.8358791067385328 25.105930744365768 -9.97144823247368 5.615803639418219 1.0000005638171954 0.6632690183968268 0.5591926048607893 0.14093554696553504 9.949478712791157e-07 1.8213097621867767e-07 0.13646048430642702 0.04548675219034293 1.0679520839164264e-10 9.97144823247368 -0.33673154542036854 FSHEEIAMATVTALR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FSHEEIAMATVTALR 15 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BU78;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 90988100.0 18702800.0 53888700.0 18396600.0 False True 24211143.287304487 50889746.47302556 15048607.56505632 1.0 2.101914224749165 0.6215570816495604 24.529167871428598 -6.707362955518977 1.8044041117206069 1.6792181446629855 0.6252595285229485 0.4527556416168421 0.4645321095389933 0.38035131030419417 2.412280666829605 0.20499211870190126 0.5224876371664036 1.9617201115037453e-07 6.707362955518977 -1.053958616140037 FSHQGVQLIDFSPCER ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSHQGVQLIDFSPCER 16 0 P55884;P55884-2;C9JQN7 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 27400300.0 5997600.0 12187000.0 9215700.0 False True 7862911.680841025 10368747.104553936 8262147.767236566 1.0 1.318690521453865 1.0507745861330644 22.906632218913458 -10.122792702648226 4.0331809333890405 0.9999486501267696 1.1847325537977647 0.387971680444839 0.10937622279699584 25435705.996681765 1.3473928413359137 12644.7382684285 0.03744239026913479 7.537152410884405e-11 10.122792702648226 0.18478390367099506 FSHQGVQLIDFSPCER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSHQGVQLIDFSPCER 16 0 P55884;P55884-2;C9JQN7 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 28605600.0 5997600.0 10223000.0 12385000.0 False True 8215074.799045704 9771314.057059776 9459918.077081632 1.0 1.18943701622715 1.151531581694245 22.96984228043635 -10.151315195230682 4.448614990463506 0.9999714101131684 1.170484298966219 0.9642492769438581 0.015474828866068366 4.388709715250149e-06 8.372792584731439e-07 0.014985950190235827 0.004994479537684823 7.058051204982794e-11 10.151315195230682 0.1705128888530506 FSHVAMILGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSHVAMILGK 10 0 Q92600;Q92600-3;Q92600-2;H7C0W0 Q92600 RQCD1 Cell differentiation protein RCD1 homolog 0 6725700.0 2496700.0 2487000.0 1742000.0 False True 3273197.878077194 2115949.294250074 1561754.5504439254 1.0 0.6464471055728125 0.47713416927954316 21.64226939110537 -13.999999999999826 0.09748903920064572 2.7596675819958065 0.10205546874939389 0.9998062280128635 0.0030322531794548047 12.100025165965041 0.09246729215504167 4.312178121820007 0.33503682763208265 1.0000000000004009e-14 13.999999999999826 -2.6576121132464126 FSILNAK(ub)GEETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSILNAKGEETK 12 1 D6RDG8;O43791;A0A590UJA7;D6RGZ4;H0Y977;D6RFL7 D6RDG8 SPOP Speckle-type POZ protein 1 15423100.0 5319700.0 4520200.0 5583200.0 True False 6974178.21604808 3845803.779601601 5005504.021836122 1.0 0.5514346867064758 0.7177195458409854 22.733591800104072 -10.098189827058592 4.936442441727 1.0000129140280232 0.6345771162718379 0.865575037882629 0.06788550947823635 9.648745322494353e-06 1.7626216859853825e-06 0.06573218376317459 0.021909953970566227 7.976459656291943e-11 10.098189827058592 -0.3654357977561853 FSILNAK(ub)GEETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSILNAKGEETK 12 1 D6RDG8;O43791;A0A590UJA7;D6RGZ4;H0Y977;D6RFL7 D6RDG8 SPOP Speckle-type POZ protein 1 19795300.0 5571100.0 5280500.0 8943700.0 True False 5394248.47996596 7389031.187443725 6601076.66475124 1.0 1.3697980756515602 1.223724989545327 22.362990548546563 -10.217448337730703 5.374810637592451 0.9999815353701323 1.2967615325984854 0.8462290203366336 0.05963408768579656 1.3195572271640655e-05 1.9211993198817364e-06 0.05774404644424568 0.01924681903942575 6.061102971627031e-11 10.217448337730703 0.296779997228353 FSILNAK(ub)GEETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSILNAKGEETK 12 1 D6RDG8;O43791;A0A590UJA7;D6RGZ4;H0Y977;D6RFL7 D6RDG8 SPOP Speckle-type POZ protein 1 34730300.0 9898500.0 6614800.0 18217000.0 True False 15016748.177282706 5434337.258331703 14616401.965205241 1.0 0.36188508951310466 0.9733400196000418 23.840069100470973 -10.905178365376416 10.660808462641617 1.0324167386942698 0.6676125545567558 0.2826412092513447 0.24962542990369296 0.12930016156220883 0.0011500471689081988 0.16248871517974148 0.08056626106723917 1.2440035927525791e-11 10.905178365376416 -0.3648041841375139 FSILNAK(ub)GEETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSILNAKGEETK 12 1 D6RDG8;O43791;A0A590UJA7;D6RGZ4;H0Y977;D6RFL7 D6RDG8 SPOP Speckle-type POZ protein 1 15397000.0 5319700.0 5086800.0 4990500.0 True False 7286536.849487026 4862048.356201865 3811846.682573747 1.0 0.6672646356745117 0.5231355802231483 22.796801861626964 -13.99999999999978 0.11395723521133407 2.5957535616792304 0.27318527538776977 0.9997230309411415 0.0033233171130530406 11.990871939039405 0.10306230222978223 4.372201221088575 0.22184306225470696 1.0000000000005072e-14 13.99999999999978 -2.3225682862914607 FSILNAK(ub)GEETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSILNAKGEETK 12 1 D6RDG8;O43791;A0A590UJA7;D6RGZ4;H0Y977;D6RFL7 D6RDG8 SPOP Speckle-type POZ protein 1 18049100.0 5571100.0 7138500.0 5339500.0 True False 4632616.491576803 7100043.483618688 6455964.762941409 1.0 1.5326206036109946 1.3935892976852036 22.14339582398084 -10.036580193441651 4.769824253018096 0.9999889296409947 1.4631049505880123 0.9366830090002818 0.05675929300306733 7.097222493725003e-06 1.4333254900346812e-06 0.054958342827900214 0.018318983039889224 9.192207229817344e-11 10.036580193441651 0.46311602094701754 FSINGHFYNHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSINGHFYNHK 11 0 P50749;P50749-2;Q9H2L5-3;Q9H2L5-2;Q9H2L5 P50749;Q9H2L5 RASSF2;RASSF4 Ras association domain-containing protein 2;Ras association domain-containing protein 4 0 21185400.0 6805700.0 6194100.0 8185600.0 False True 8922338.606492551 5269964.424412698 7338632.6338196425 1.0 0.5906483330029509 0.8225010232720279 23.08899046935653 -10.164684440700427 5.375675667416799 1.0000094866321942 0.7065746781374106 0.6810766306475262 0.09465346444207477 1.0762126816362361e-05 1.672226692177765e-06 0.09165078375414754 0.03054927428704263 6.844087595268754e-11 10.164684440700427 -0.29343480849478365 FSINGHFYNHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSINGHFYNHK 11 0 P50749;P50749-2;Q9H2L5-3;Q9H2L5-2;Q9H2L5 P50749;Q9H2L5 RASSF2;RASSF4 Ras association domain-containing protein 2;Ras association domain-containing protein 4 0 11747700.0 3820600.0 1363300.0 6563800.0 False True 3699317.144290704 1907672.799515579 4844543.870220856 1.0 0.5156824151883713 1.3095778710667247 21.818827558048373 -6.741572429449297 1.6807516606104194 0.7123668202874707 1.310224703239766 0.6120937263664461 0.20348373842761486 0.3149615479132634 1.7475730911003513 0.09574948804292827 0.23457335866077642 1.8131242669087164e-07 6.741572429449297 0.5978578829522954 FSINGHFYNHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSINGHFYNHK 11 0 P50749;P50749-2;Q9H2L5-3;Q9H2L5-2;Q9H2L5 P50749;Q9H2L5 RASSF2;RASSF4 Ras association domain-containing protein 2;Ras association domain-containing protein 4 0 17698400.0 6805700.0 5816100.0 5076600.0 False True 9321951.207127068 5559125.470729271 3877611.6358589064 1.0 0.5963478404048135 0.41596566530988605 23.152200530879423 -13.999999999999998 0.10896264832145883 2.951310911596075 0.08006431146590964 0.999748333773971 0.003873499278218897 12.018836863868872 0.09999616467919945 5.1696222418965485 0.2984323660182095 1.0000000000000041e-14 13.999999999999998 -2.8712466001301653 FSINGHFYNHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSINGHFYNHK 11 0 P50749;P50749-2;Q9H2L5-3;Q9H2L5-2;Q9H2L5 P50749;Q9H2L5 RASSF2;RASSF4 Ras association domain-containing protein 2;Ras association domain-containing protein 4 0 8957100.0 3820600.0 2202800.0 2933700.0 False True 3176998.181278083 2190933.0791784357 3547123.1061037886 1.0 0.6896236491696824 1.1165014594615874 21.59923283348265 -6.711752319789954 1.7891770802535913 0.8095234532388791 1.1155401836353744 0.4732662323548833 0.1307563986502273 0.3715929985115393 2.319893598738267 0.05813698533943062 0.14737021353104082 1.9419930897405479e-07 6.711752319789954 0.30601673039649535 FSINGHFYNHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSINGHFYNHK 11 0 P50749;P50749-2;Q9H2L5-3;Q9H2L5-2;Q9H2L5 P50749;Q9H2L5 RASSF2;RASSF4 Ras association domain-containing protein 2;Ras association domain-containing protein 4 0 16347300.0 3198100.0 7325500.0 5823700.0 False True 4140003.493975684 6917829.485367963 4763846.356208126 1.0 1.6709718954185488 1.1506865545259142 21.981200554618646 -10.311151898791017 3.7933892362260924 0.9990042586863194 1.4108292250621042 0.45395148707888944 0.21240560128495442 37735920.03711345 524.2217329596818 330052.9645565943 0.07271208693256541 4.884814782319038e-11 10.311151898791017 0.4118249663757848 FSIQTMCPIEGEGNIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSIQTMCPIEGEGNIAR 17 0 A8MU58;Q13155-2;Q13155 A8MU58 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 0 9277800.0 1477000.0 4224600.0 3576200.0 False True 1936361.3032883464 3594306.147361821 3206169.1293327035 1.0 1.8562166788077914 1.6557700899558145 20.88491673775775 -10.160125650322735 4.555325877598483 0.9999067905685612 1.7559933843195576 0.9499150337257399 0.08183197806055867 57301225.6057082 14.689546755692387 67843.00709231303 0.028013262560630758 6.916308389475067e-11 10.160125650322735 0.7560865937509964 FSIQTMCPIEGEGNIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSIQTMCPIEGEGNIAR 17 0 A8MU58;Q13155-2;Q13155 A8MU58 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 0 10484100.0 1477000.0 4976600.0 4030500.0 False True 2023086.8144241858 4756717.356584538 3078578.910753129 1.0 2.351217615907601 1.521723580423492 20.94812679928064 -10.275181759140557 5.41533978759294 0.9998887353802308 1.9364705981655985 0.6295499277606029 0.33863952193654107 0.00045495974655344987 6.0893728671974384e-05 0.3279246198656762 0.10929543573562893 5.3066230714381126e-11 10.275181759140557 0.9365818627853677 FSISAHGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSISAHGK 8 0 Q8NE71-2;Q8NE71;H0YGW7;Q5STZ8 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 26048700.0 8610700.0 5125000.0 12313000.0 False True 11288711.086137405 4360369.977093538 11038968.87463609 1.0 0.3862593296809673 0.9778768178585064 23.42837743678919 -10.905345576177597 10.688465241050654 1.0309473605698984 0.6820680737699382 0.2780080482748477 0.24152682815700505 0.12374772754322512 0.0010958776072648323 0.16247324587660375 0.07795244859286508 1.2435247222917385e-11 10.905345576177597 -0.3488792867999603 FSISAHGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSISAHGK 8 0 Q8NE71-2;Q8NE71;H0YGW7;Q5STZ8 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 14041100.0 3070100.0 1263800.0 9707200.0 False True 2972641.355987775 1768441.9306299358 7164593.110242213 1.0 0.5949059166077243 2.410177432205406 21.503313984419993 -6.848127514677271 1.243996715622652 0.7841120665282569 2.480201729282004 0.93754511149963 0.19443615171779066 0.15953304510903496 0.4760126653639577 0.12235661779703003 0.2828389107572043 1.4186409285540713e-07 6.848127514677271 1.6960896627537472 up FSISAHGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSISAHGK 8 0 Q8NE71-2;Q8NE71;H0YGW7;Q5STZ8 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 16513300.0 8610700.0 3935200.0 3967400.0 False True 11794308.485417953 3761329.852033808 3030381.831167835 1.0 0.31891058782159015 0.25693594795442964 23.491587498312082 -13.999999999999998 0.33920490978898576 8.839417423337212 0.24710874141595357 0.9997336144997814 0.005494216169092554 19.631198461039233 0.18677435236911713 110.30740755254642 0.019202483552635617 1.0000000000000041e-14 13.999999999999998 -8.592308681921258 FSISAHGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSISAHGK 8 0 Q8NE71-2;Q8NE71;H0YGW7;Q5STZ8 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 8023300.0 3070100.0 3028200.0 1925000.0 False True 2552924.178490773 3011886.485549365 2327508.599805639 1.0 1.1797790592158988 0.9117029872707015 21.28371925985427 -6.726008106479618 1.7377793952659286 1.10866978609238 0.9119755332397713 0.5406342480512998 0.07560168725675177 0.343789439640152 2.0320176425146106 0.03450242200797175 0.08600526385054821 1.879281738067702e-07 6.726008106479618 -0.19669425285260866 FSISPDEDSSSYSSNSDFNYSYPTK(ub)QAALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSISPDEDSSSYSSNSDFNYSYPTKQAALK 30 1 Q96QD8;F8VUY8 Q96QD8 SLC38A2 Sodium-coupled neutral amino acid transporter 2 1 8305200.0 3674400.0 4630800.0 0.0 True False 4817173.982940213 3939902.690717019 0.0 1.0 0.8178867328998273 0.0 22.19975560032654 -7.223517493592546 0.8733242421301742 0.9898914710588422 5.532480139053116e-16 0.9891091834953907 0.04538391968464421 0.09541944400339317 0.13919272304178734 0.038342905936783495 0.06739055856294625 5.97698968599215e-08 7.223517493592546 -0.9898914710588417 down FSISPDEDSSSYSSNSDFNYSYPTK(ub)QAALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSISPDEDSSSYSSNSDFNYSYPTKQAALK 30 1 Q96QD8;F8VUY8 Q96QD8 SLC38A2 Sodium-coupled neutral amino acid transporter 2 1 32401800.0 9898100.0 8497700.0 14006000.0 True False 9583890.23344602 11890875.924920093 10337408.429006562 1.0 1.2407149534562818 1.0786234167134867 23.192179954019117 -10.431942007275724 4.887837520829021 0.9997329171925706 1.1596691850849086 0.5640383078498308 0.0661735927739912 0.00019291723352807044 2.242051655173827e-05 0.06417890304791585 0.02135743523101954 3.6987756741143105e-11 10.431942007275724 0.15993626789233795 FSISPDEDSSSYSSNSDFNYSYPTK(ub)QAALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSISPDEDSSSYSSNSDFNYSYPTKQAALK 30 1 Q96QD8;F8VUY8 Q96QD8 SLC38A2 Sodium-coupled neutral amino acid transporter 2 1 95238000.0 29645000.0 38661000.0 26932000.0 True False 44973632.33980357 31761642.490228266 21608878.39528504 1.0 0.7062280905008838 0.4804788332865048 25.422576073613047 -7.376455301330039 0.1561961792282666 1.2715440459704874 8.446568032284281e-12 0.9999895310866012 0.0006881775502759468 0.11863554143782788 0.010976994741094398 0.028691700927218834 0.05474930798109753 4.20285782311038e-08 7.376455301330039 -1.2715440459620408 down FSISPDEDSSSYSSNSDFNYSYPTK(ub)QAALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSISPDEDSSSYSSNSDFNYSYPTKQAALK 30 1 Q96QD8;F8VUY8 Q96QD8 SLC38A2 Sodium-coupled neutral amino acid transporter 2 1 31109100.0 9898100.0 10343000.0 10868000.0 True False 8230708.710178673 10287280.206075251 13140448.552045533 1.0 1.2498656638587242 1.596514834232334 22.972585229453394 -6.966522207983798 0.3308877471168425 0.9582018677792379 1.8995417416523583 0.9999411714152665 0.0018760088664472522 0.07744813262054936 0.013058826282860378 0.005042286019779085 0.030213972263225915 1.0801343859634996e-07 6.966522207983798 0.9413398738731205 FSISPDEDSSSYSSNSDFNYSYPTK(ub)QAALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSISPDEDSSSYSSNSDFNYSYPTKQAALK 30 1 Q96QD8;F8VUY8 Q96QD8 SLC38A2 Sodium-coupled neutral amino acid transporter 2 1 90634000.0 29645000.0 31847000.0 29142000.0 True False 38376036.89031268 30074686.454237107 23838455.022170976 1.0 0.7836840093779696 0.6211807407395044 25.193702395705497 -6.974280797721225 0.1171644470719585 1.305370445562619 0.09532711889565915 0.999999500024657 0.00010956815865970444 0.07493647440303343 0.0034814137855102515 0.0118338582477305 0.023809401733407835 1.0610093285004441e-07 6.974280797721225 -1.21004332666696 FSK(ub)SATSPEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSKSATSPEGK 11 1 P13639 P13639 EEF2 Elongation factor 2 1 38740400.0 11205100.0 16655600.0 10879700.0 True False 14689994.61034275 14170649.403020311 9753973.009451661 1.0 0.9646463309825325 0.6639875145076094 23.80833053079101 -6.928976602613582 0.7551458305160959 1.0047499876827215 0.6038423226756333 0.996333232138138 0.009128934789211377 0.09317280862715231 0.08030929699456416 0.008266811826614635 0.027359157327870465 1.1776694181312535e-07 6.928976602613582 -0.4009076650070882 FSK(ub)SATSPEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSKSATSPEGK 11 1 P13639 P13639 EEF2 Elongation factor 2 1 43368700.0 19523300.0 4600600.0 19244800.0 True False 18903543.52801411 6437643.571812055 14204009.54837536 1.0 0.34055221246068434 0.7513940191861768 24.17215336167966 -10.846182550699181 9.397520775863143 1.0162771697967579 0.5459731158237119 0.6195358025212516 0.1677254652467671 0.05271310008299458 0.0008628000716168235 0.149661458537028 0.05413316113630165 1.4250084817418341e-11 10.846182550699181 -0.470304053973046 FSK(ub)SATSPEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSKSATSPEGK 11 1 P13639 P13639 EEF2 Elongation factor 2 1 64130700.0 6333000.0 19329700.0 38468000.0 True False 9607624.004316948 15880164.011364583 30864782.93887666 1.0 1.6528710953123502 3.212530270232092 23.195748261404194 -6.9564285872087614 0.48315054076158176 0.9636514741554595 3.967122839273967 0.999613928843838 0.018237999237265014 0.08100254775584172 0.026040048251912765 0.02213320153451355 0.12864652300716461 1.1055322415578449e-07 6.9564285872087614 3.0034713651185077 FSK(ub)SATSPEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSKSATSPEGK 11 1 P13639 P13639 EEF2 Elongation factor 2 1 41528300.0 11205100.0 15599900.0 14723300.0 True False 15347928.27644173 14910644.836029243 11245959.775881784 1.0 0.9715086340946943 0.7327347100744369 23.871540592313902 -6.929241369724446 0.7529923430765625 1.0037350921064032 0.6846492730921104 0.996387037356566 0.007203355094073638 0.09303370335263086 0.07962382667628554 0.006533226554636661 0.021695760570073552 1.1769516721893493e-07 6.929241369724446 -0.3190858190142928 FSK(ub)SATSPEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSKSATSPEGK 11 1 P13639 P13639 EEF2 Elongation factor 2 1 51223600.0 19523300.0 22671000.0 9029300.0 True False 16234488.97883746 22548866.82315881 10917284.8832338 1.0 1.3889483588028233 0.6724748094913905 23.952558637113935 -6.759290557427479 1.615298008415685 1.226121701018449 0.6699621006415443 0.6880218517879417 0.16357538685686093 0.28410178848454154 1.4608470708778027 0.07990892519061567 0.19215644634933163 1.740641936497467e-07 6.759290557427479 -0.5561596003769048 FSK(ub)SATSPEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSKSATSPEGK 11 1 P13639 P13639 EEF2 Elongation factor 2 1 47370800.0 6333000.0 15419700.0 25618100.0 True False 8198193.342093107 14561580.139994312 20955868.663903616 1.0 1.7761937944582005 2.5561569225632956 22.966874583496644 -6.971065084666209 0.23133571206040968 0.6880454274457543 3.666627073684988 0.9999895402501708 0.0020546465472462603 0.07595856197776041 0.007782343796018547 0.019845044919083392 0.07726633687969177 1.0688946794746318e-07 6.971065084666209 2.978581646239234 FSK(ub)SQLDIIIHSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSKSQLDIIIHSLK 14 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 7000500.0 1609400.0 2524800.0 2866300.0 True False 2109938.9854517705 2148109.681593318 2569722.771491064 1.0 1.0180909004500784 1.2179133089674852 21.008769849460954 -6.9246233146729 0.7896632338539347 0.9962814607817809 1.2538338630254584 0.9953721653335527 0.006716955486966591 0.09552706147843702 0.09206790477985356 0.005933920241796076 0.018643426934934707 1.1895335220485322e-07 6.9246233146729 0.2575524022436775 FSK(ub)SQLDIIIHSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSKSQLDIIIHSLK 14 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 32316300.0 10914200.0 9575600.0 11826500.0 True False 10567734.695131047 13399187.016094325 8728784.862605028 1.0 1.2679337060068168 0.8259844814827446 23.333162817246606 -6.742592704939097 1.6772806135425786 1.1589387943668206 0.8255797436136612 0.6165034817911605 0.11256980129888408 0.31313984762344305 1.7307175583403707 0.05307420040432978 0.12986664229424974 1.8088697458753885e-07 6.742592704939097 -0.3333590507531594 FSK(ub)SQLDIIIHSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSKSQLDIIIHSLK 14 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 10622900.0 1609400.0 5482300.0 3531200.0 True False 2204438.6723996513 5240073.858458268 2697203.2873468413 1.0 2.377055857378043 1.2235329207007555 21.071979910983845 -6.602654052601887 2.180506181461319 1.9244831051733244 1.2273488337240044 0.02831629057086904 0.5947993411280936 0.6331781394874588 5.693359618619666 0.22609428430013787 0.6613822563008847 2.49658264620789e-07 6.602654052601887 -0.69713427144932 FSK(ub)SQLDIIIHSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSKSQLDIIIHSLK 14 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 28574200.0 10914200.0 7934200.0 9725800.0 True False 9075640.88104102 7891456.889784598 11759419.812981648 1.0 0.869520620441232 1.2957123322879636 23.113568092680882 -6.824525745413853 1.3520223488715395 0.9299713141738519 1.3059622365487609 0.8944900224370732 0.05791513166549383 0.18767987176839462 0.6728212197404609 0.0336485889621635 0.07748320523325433 1.4978704551452246e-07 6.824525745413853 0.37599092237490894 FSK(ub)SQLDIIIHSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSKSQLDIIIHSLK 14 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 30130800.0 7574200.0 5330600.0 17226000.0 True False 9804951.209802879 5033947.424026007 14091044.753686 1.0 0.5134087173216245 1.4371356320057904 23.225079020797125 -6.763557737791241 1.5988913099221136 0.7186179696688881 1.4411405628542093 0.705403254081652 0.20478084318882964 0.2769747616616496 1.3962558370115192 0.10101289995071354 0.24192307807539448 1.7236229267146291e-07 6.763557737791241 0.7225225931853212 FSK(ub)VPTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSKVPTK 7 1 O43681 O43681 ASNA1 ATPase ASNA1 1 2837440.0 821180.0 1146300.0 869960.0 True False 682847.5544422189 1140124.6543772647 1051864.613759434 1.0 1.6696620599433363 1.5404091395167188 19.381204007566637 -10.157455642339158 4.5044032212425344 0.9999030338969178 1.605035599743939 0.9669048849477798 0.05276728384891346 36939538.25900964 6.945463442463422 37150.63964978002 0.018063644781910287 6.958960280043837e-11 10.157455642339158 0.6051325658470211 FSK(ub)VSSPAPMEGGEEEEELLGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSKVSSPAPMEGGEEEEELLGPK 23 1 O14497;A0A1B0GTU5;O14497-3;H0Y488;O14497-2 O14497 ARID1A AT-rich interactive domain-containing protein 1A 1 4953400.0 1935500.0 3017900.0 0.0 True False 2651106.6549207903 2884559.199139268 0.0 1.0 1.088058525968829 0.0 21.33816328080816 -6.966592357116089 1.1753478061940161 1.0540422175803714 1.0729729468149266e-20 0.9766917537459519 0.07533845873811693 0.10132395990657576 0.2769067738115049 0.05357643305913094 0.10048999171548921 1.0799599320525462e-07 6.966592357116089 -1.0540422175803714 down FSLCILTPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSLCILTPEK 10 0 A0A494BZV2;Q6WCQ1-3;Q6WCQ1;Q6WCQ1-2;J3KSK7 A0A494BZV2 MPRIP Myosin phosphatase Rho-interacting protein 0 3010350.0 810990.0 587560.0 1611800.0 False True 1110834.9191806838 561599.6563989081 1231126.036062992 1.0 0.5055653605246098 1.108288922868063 20.0832130035354 -6.688709691203279 1.870807558036576 0.6896391773430508 1.1061809281377797 0.3643565228068274 0.20916783899642444 0.4195177207654213 2.8456688864184585 0.08947267811809376 0.23338932639201307 2.0478130618730642e-07 6.688709691203279 0.4165417507947289 FSLDFNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSLDFNLR 8 0 H0YJV7;P25490;Q96MM3;O15391 H0YJV7 YY1;ZFP42;YY2 Transcriptional repressor protein YY1;Zinc finger protein 42 homolog;Transcription factor YY2 0 5728300.0 2447600.0 1853700.0 1427000.0 False True 2369902.2777485033 2593892.0769177987 1053225.890917633 1.0 1.0945143608968106 0.44441743476369727 21.176396140551386 -6.86997804193133 1.1341529249778866 1.0534517403639148 0.4063507895545339 0.9646642985174515 0.053909986812451266 0.1368790016844081 0.329078144031896 0.03688873945456859 0.08733614777631604 1.3490310883130478e-07 6.86997804193133 -0.6471009508093808 down FSLDFNLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSLDFNLR 8 0 H0YJV7;P25490;Q96MM3;O15391 H0YJV7 YY1;ZFP42;YY2 Transcriptional repressor protein YY1;Zinc finger protein 42 homolog;Transcription factor YY2 0 39295900.0 9469900.0 11783000.0 18043000.0 False True 14366530.64242559 9680231.58900081 14476793.141472153 1.0 0.6738044020463967 1.0076749565911862 23.776208373239065 -10.915462452199327 11.043463689422216 1.0185575332063486 0.8407396793187916 0.23276845391105794 0.13630208312913225 0.056903968652033995 0.00043559830413195805 0.12058703117333287 0.04399130816770896 1.214891651825768e-11 10.915462452199327 -0.177817853887557 FSLDFNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSLDFNLR 8 0 H0YJV7;P25490;Q96MM3;O15391 H0YJV7 YY1;ZFP42;YY2 Transcriptional repressor protein YY1;Zinc finger protein 42 homolog;Transcription factor YY2 0 4494530.0 2447600.0 962130.0 1084800.0 False True 2035287.847064922 956946.8147221472 1311626.6644515097 1.0 0.47017762922436507 0.644442832173837 20.956801415985662 -10.381190812764725 6.296769033023509 1.0000561824867293 0.5573102306991017 0.8958801438771853 0.07114347119146025 5.6119074246167526e-05 5.514994676577473e-06 0.06889306561240305 0.022961456592992688 4.157279150530585e-11 10.381190812764725 -0.44274595178762766 FSLDFNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSLDFNLR 8 0 H0YJV7;P25490;Q96MM3;O15391 H0YJV7 YY1;ZFP42;YY2 Transcriptional repressor protein YY1;Zinc finger protein 42 homolog;Transcription factor YY2 0 30953700.0 9469900.0 9840800.0 11643000.0 False True 12258972.229636455 9293150.829241572 9524093.467268445 1.0 0.7580693271149668 0.7769079894188556 23.547334695331514 -10.56850281833932 6.32988927579019 1.000431633118093 0.7674886582669113 0.9951006287825069 0.007690851680188648 4.6932689515866235e-05 3.1993025498984807e-06 0.007460163764115374 0.0024822117062935026 2.700829581325765e-11 10.56850281833932 -0.23294297485118165 FSLFAGGMLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSLFAGGMLR 10 0 Q9BVK6 Q9BVK6 TMED9 Transmembrane emp24 domain-containing protein 9 0 4806000.0 1214100.0 1938100.0 1653800.0 False True 1591696.857361126 1648943.0346546299 1482680.6403697855 1.0 1.0359655024942453 0.931509435049034 20.602134166496178 -6.813726787236064 1.3986493297984388 1.0195162494254084 0.9295190065173325 0.8693840470141911 0.01565896064134024 0.20175377853207124 0.7771049947528141 0.008801233684722217 0.020328443402681654 1.5355827073830494e-07 6.813726787236064 -0.08999724290807587 FSLFAGGMLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSLFAGGMLR 10 0 Q9BVK6 Q9BVK6 TMED9 Transmembrane emp24 domain-containing protein 9 0 4484800.0 1214100.0 1247100.0 2023600.0 False True 1662985.579818826 1191998.9983917898 1545667.357350211 1.0 0.7167825222643556 0.9294532532979652 20.66534422801907 -10.494955440902412 5.2807262896778235 1.0003807867560475 0.823117887781159 0.479800702549257 0.08682246237617602 0.0003900623015958063 3.730533571004353e-05 0.08424466041987648 0.028021829238303445 3.199223336730724e-11 10.494955440902412 -0.17726289897488845 FSLGWSSLVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSLGWSSLVHR 11 0 Q8IWA4 Q8IWA4 MFN1 Mitofusin-1 0 2853750.0 629250.0 874900.0 1349600.0 False True 824952.8436656685 744368.3303334886 1209956.33827734 1.0 0.9023162184954676 1.4666975786166307 19.65395212815394 -6.862266800240855 1.1741258178177993 0.9466414406268199 1.4952484136139692 0.9563427840783263 0.05145805793853364 0.14449076365878796 0.37720531054526885 0.03414805197937691 0.07993188804434824 1.3731981186821056e-07 6.862266800240855 0.5486069729871493 FSLVGIGGQDLNEGNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSLVGIGGQDLNEGNR 16 0 P13796;P13796-2 P13796 LCP1 Plastin-2 0 156079000.0 41527000.0 44299000.0 70253000.0 False True 54442299.14803999 37689761.87614958 62983893.47436122 1.0 0.6922882109306817 1.1568926085045537 25.698224658669815 -6.728100151914514 1.7299309480750025 0.8144326242195066 1.1565333847420896 0.5505371199281852 0.12937523638370577 0.33981091569437566 1.9913468107867285 0.05928386287201197 0.1474390766082007 1.8702507952652703e-07 6.728100151914514 0.342100760522583 FSLVGIGGQDLNEGNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSLVGIGGQDLNEGNR 16 0 P13796;P13796-2 P13796 LCP1 Plastin-2 0 131668000.0 43658000.0 14728000.0 73282000.0 False True 42272100.687180996 20608967.20550536 54087245.78712399 1.0 0.4875311818074616 1.2795021990361113 25.33320247224322 -6.7320292818755885 1.7159193486414022 0.692296831724252 1.2792007746766 0.5686168098975011 0.21539713659975687 0.3324434289564041 1.9185590119000338 0.09944139637896099 0.24618387485608986 1.8534066550926622e-07 6.7320292818755885 0.586903942952348 FSLVGIGGQDLNEGNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSLVGIGGQDLNEGNR 16 0 P13796;P13796-2 P13796 LCP1 Plastin-2 0 109149000.0 11402000.0 97747000.0 0.0 False True 17297667.597856008 80303284.14920324 0.0 1.0 4.642434229638948 0.0 24.044074183468947 -6.697606844516047 1.8404026621691203 3.267454293755475 0.015130870961872375 0.4054564494676087 1.5382625913892183 0.4007176391242925 2.63724965128816 0.6673737911737402 1.720760856263434 2.0062874452895293e-07 6.697606844516047 -3.2523234227936024 FSLVGIGGQDLNEGNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSLVGIGGQDLNEGNR 16 0 P13796;P13796-2 P13796 LCP1 Plastin-2 0 141125000.0 41527000.0 39095000.0 60503000.0 False True 56880654.12497838 37367653.630123466 46213437.498398796 1.0 0.6569483808681089 0.8124631864615773 25.761434720192707 -10.173138201472387 5.134925946416807 1.0000150609933047 0.7347057836646275 0.795089128002362 0.0634886535261047 1.0947378319473746e-05 1.7627709989199474e-06 0.06147611215451004 0.02049087481487009 6.712152243921543e-11 10.173138201472387 -0.26530927732867726 FSLVGIGGQDLNEGNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSLVGIGGQDLNEGNR 16 0 P13796;P13796-2 P13796 LCP1 Plastin-2 0 82158000.0 43658000.0 17614000.0 20886000.0 False True 36303561.37733306 17519109.885894753 25253166.03404701 1.0 0.48257276204403465 0.6956112589497732 25.113607747677495 -10.24018683937037 5.549376303599736 1.0000249606239173 0.5890920104968871 0.8322244267354854 0.0869726021648208 2.686025869009013e-05 3.6776526391337425e-06 0.08421596613905825 0.02807028664671383 5.751924285241195e-11 10.24018683937037 -0.41093295012703024 FSLVGIGGQDLNEGNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSLVGIGGQDLNEGNR 16 0 P13796;P13796-2 P13796 LCP1 Plastin-2 0 49437000.0 11402000.0 20994000.0 17041000.0 False True 14760113.76702129 19825665.44479082 13939712.855425712 1.0 1.3431919128623222 0.9444177108289904 23.815200505561396 -6.678959219875089 1.9054563186713134 1.217344159207463 0.9459437139384735 0.3193918009197093 0.14548618541825864 0.4408585921220082 3.093763816447505 0.06128435897199516 0.16185687740694923 2.0943091016307577e-07 6.678959219875089 -0.27140044526898943 FSLVPHNYGLVLYENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSLVPHNYGLVLYENK 16 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 0 13381900.0 3048300.0 5280400.0 5053200.0 False True 3996350.819779188 4492584.902837988 4530343.337717132 1.0 1.1241718020857385 1.1336200303774755 21.930251805042065 -13.337145896395596 0.3727103642340776 1.0465486868968781e-06 1.1345795947983481 0.99977590703244 0.0009114054163347454 14.019845367964768 0.19732603396825446 10.991529841704981 0.002619137917865571 4.6010198147833474e-14 13.337145896395596 1.1345785482496613 FSLVPHNYGLVLYENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSLVPHNYGLVLYENK 16 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 0 17804200.0 5729600.0 5043300.0 7031300.0 False True 5547716.984224479 7057115.990462057 5189591.595521476 1.0 1.2720757043897002 0.9354463485211358 22.403462760037154 -6.691656454747745 1.8604561709984904 1.1703111502773564 0.9365849867541244 0.37816273661210587 0.1150309633000685 0.4131520961870582 2.7738544359111956 0.049438175840207946 0.12847579294830203 2.0339653270888907e-07 6.691656454747745 -0.23372616352323206 FSLVPHNYGLVLYENK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSLVPHNYGLVLYENK 16 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 0 21461800.0 3048300.0 8153500.0 10260000.0 False True 4175338.8872100473 7793251.409981119 7836799.311332849 1.0 1.8664955397640917 1.8769253282263232 21.993461866564957 -11.079053328794924 0.733978015696871 2.246929926769436e-12 1.8749473735047895 0.9999829262889081 0.001698051095736406 3.337131689978941 0.38051597840683277 5.572344018292867 0.0015792976377175126 8.335788197837308e-12 11.079053328794924 1.8749473735025426 FSLVPHNYGLVLYENK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSLVPHNYGLVLYENK 16 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 0 14611200.0 5729600.0 3402100.0 5479500.0 False True 4764416.264317366 3383772.2120360225 6625238.115654544 1.0 0.7102175847602689 1.3905665979006963 22.18386803547143 -6.7909707206611785 1.4923684022090211 0.8382413391772464 1.398004830359729 0.8044612727687984 0.12326935514226414 0.2339177375112435 1.0291634554806928 0.06501061219177587 0.1521043539789211 1.6181891293140053e-07 6.7909707206611785 0.5597634911824826 FSLYFLAYEDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSLYFLAYEDK 11 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 6681620.0 2715900.0 829020.0 3136700.0 False True 2629685.2411084985 1160052.0092821887 2315104.1710170563 1.0 0.44113720955941815 0.8803731088520557 21.326458696496708 -9.926955359563477 6.739659556668141 1.0000000198864694 0.6607551592057402 0.4430119609404055 0.17931730499659104 5.355792760709453e-08 8.445254221247653e-09 0.17362324433337673 0.05787441132821398 1.1831631649280684e-10 9.926955359563477 -0.3392448606807291 FSLYFLAYEDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSLYFLAYEDK 11 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 38557000.0 11795000.0 15711000.0 11051000.0 False True 17893877.330004517 12907249.299396722 8866765.006174637 1.0 0.7213221070736748 0.49551949209503154 24.09296269546271 -7.088705961646442 0.1599547633395667 1.2367682676218243 1.9509837972886146e-12 0.9999977611666113 0.00030867211366432715 0.07539760915846325 0.0054379758907601465 0.01200921940316978 0.028643151365237672 8.152560649656183e-08 7.088705961646442 -1.2367682676198735 down FSLYFLAYEDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSLYFLAYEDK 11 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 25799000.0 11795000.0 5407500.0 8596500.0 False True 15268860.014209438 5106567.871425468 7032025.207538697 1.0 0.3344432961382327 0.46054683853245004 23.86408901755516 -10.152432154780671 5.998065351169974 1.0000049681337708 0.39749506733915335 0.9681905990869878 0.051481555603906735 3.420247271143955e-06 4.833390961871123e-07 0.049847212389553225 0.016615600624227393 7.039921965785933e-11 10.152432154780671 -0.6025099007946175 FSLYFLAYEDKNDIPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSLYFLAYEDKNDIPK 16 1 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 9485400.0 2882200.0 5118100.0 1485100.0 False True 3778592.1112645078 4354499.430197545 1331436.0980851194 1.0 1.1524132009952008 0.35236301216951244 21.84941736132346 -6.857376237507398 1.1988647234948349 1.0821880582426955 0.3155077547131508 0.9503741906749998 0.0772672382219195 0.14953285972595234 0.4098825141509125 0.050317482635767644 0.11713497468136363 1.3887490104472145e-07 6.857376237507398 -0.7666803035295446 down FSLYFLAYEDKNDIPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSLYFLAYEDKNDIPK 16 1 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 97073800.0 50473300.0 21488000.0 25112500.0 False True 48871052.71918756 30068270.45843964 18534782.89114861 1.0 0.615257269599072 0.37925892445266596 25.54247684586577 -8.79992700995055 0.15838678967181766 1.4478118814037289 1.240670752109305e-06 0.9998390145444286 0.0032459691534260583 0.322999310529936 0.04649547377689939 0.22543356742549686 0.15661939460455193 1.5851595811878898e-09 8.79992700995055 -1.4478106407329767 FSLYFLAYEDKNDIPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSLYFLAYEDKNDIPK 16 1 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 1075762000.0 327209000.0 351205000.0 397348000.0 False True 496399975.18214875 288529723.7728107 318811993.6361849 1.0 0.5812444363377289 0.6422482062357078 28.88692780243866 -10.45588991230839 6.060212582800871 1.0001957459474209 0.6117463212867733 0.981820761474763 0.02490468477270096 6.589904325260517e-05 5.916686273223902e-06 0.024125833588845232 0.008037952447267996 3.5003388456998444e-11 10.45588991230839 -0.3884494246606476 FSLYFLAYEDKNDIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSLYFLAYEDKNDIPK 16 1 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 10390400.0 2882200.0 4327000.0 3181200.0 False True 3947827.2285263333 4135818.8325244705 2429866.0788705745 1.0 1.0476190048641798 0.6154945336292258 21.912627422846352 -6.87956627153305 1.082174340546544 1.0293501910231015 0.5851187170352736 0.9733356693224086 0.03159062512711029 0.12801688744737774 0.27459091806163033 0.022495166694251636 0.05434149588085836 1.3195739348444426e-07 6.87956627153305 -0.4442314739878279 FSLYFLAYEDKNDIPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSLYFLAYEDKNDIPK 16 1 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 86194500.0 50473300.0 18290600.0 17430600.0 False True 41970785.29631552 18192064.907400176 21075257.87001151 1.0 0.4334459024048139 0.5021411374893107 25.322882121300047 -10.403731487619444 5.934517193735254 1.0001539977655174 0.46779351994786716 0.9876586950096211 0.028044712286260168 5.7157914616392166e-05 5.7428784723918505e-06 0.027161911875869985 0.00905139196948851 3.947012596272604e-11 10.403731487619444 -0.5323604778176503 FSLYFLAYEDKNDIPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSLYFLAYEDKNDIPK 16 1 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 891338000.0 327209000.0 297861000.0 266268000.0 False True 423578500.7536628 281284773.50913745 217809956.140396 1.0 0.664067635653496 0.5142139078183904 28.65805412453111 -13.999999999997149 0.109249582982993 2.623084240946386 0.236319106199712 0.9997468749957954 0.0032315064096565638 12.017101601906472 0.10017565585670404 4.308382245253919 0.2468764566822079 1.0000000000065647e-14 13.999999999997149 -2.386765134746674 FSMGSVVAGLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSMGSVVAGLLK 12 0 Q9H845;H0Y8Z9 Q9H845 ACAD9 Acyl-CoA dehydrogenase family member 9, mitochondrial 0 7671700.0 1174500.0 2415300.0 4081900.0 False True 1539780.8738741775 2054946.6547656585 3659544.144349635 1.0 1.334570840326971 2.3766655414689044 20.554293625005155 -6.950604291168361 0.5521726254543787 0.985770272525079 2.774604722235221 0.9992478362025445 0.016078014067347893 0.08324405692070977 0.03496556298711252 0.017402381423964945 0.0864865631427162 1.1204583277605412e-07 6.950604291168361 1.788834449710142 up FSMGSVVAGLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSMGSVVAGLLK 12 0 Q9H845;H0Y8Z9 Q9H845 ACAD9 Acyl-CoA dehydrogenase family member 9, mitochondrial 0 11862600.0 4817300.0 3097800.0 3947500.0 False True 4664377.448356708 4334767.694813587 2913531.3275384423 1.0 0.9293346738782375 0.6246345540850043 22.1532531076137 -6.943154062931986 0.6295425657673629 1.0033237849469674 0.5342367906370308 0.9985484604424678 0.0062051318559515215 0.08635689863067521 0.04827618545480344 0.006195729693396694 0.02588272233357491 1.1398453636562418e-07 6.943154062931986 -0.4690869943099366 FSMGSVVAGLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSMGSVVAGLLK 12 0 Q9H845;H0Y8Z9 Q9H845 ACAD9 Acyl-CoA dehydrogenase family member 9, mitochondrial 0 5105000.0 1734700.0 0.0 3370300.0 False True 2631666.7235573395 0.0 2704158.727745033 1.0 0.0 1.027546042794394 21.32754536587633 -12.106613187112012 14.806980173192276 0.8907137399116883 0.5623957192574869 0.0 0.4913082111566383 0.0 0.0 0.0 0.14157655160916813 7.823242868260393e-13 12.106613187112012 -0.32831802065420146 FSMGSVVAGLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSMGSVVAGLLK 12 0 Q9H845;H0Y8Z9 Q9H845 ACAD9 Acyl-CoA dehydrogenase family member 9, mitochondrial 0 17295000.0 1174500.0 4680500.0 11440000.0 False True 1608744.3896690612 4473700.0336562935 8738107.614195693 1.0 2.7808644197208916 5.431632066790444 20.617503686528046 -6.96538513560866 0.3513800546390496 0.7478686537901889 7.554264035459423 0.9999208655171623 0.01619728272017818 0.07783051490541137 0.014400507367852752 0.036260223079706284 0.2276337786441483 1.0829661055812075e-07 6.96538513560866 6.806395381669234 FSMGSVVAGLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSMGSVVAGLLK 12 0 Q9H845;H0Y8Z9 Q9H845 ACAD9 Acyl-CoA dehydrogenase family member 9, mitochondrial 0 9083000.0 4817300.0 1598500.0 2667200.0 False True 4005798.3925747094 1589888.5632225908 3224899.1882605683 1.0 0.39689679994122146 0.8050577867918556 21.933658383047977 -10.052976218947128 6.053675935162817 1.0000007379425229 0.6009772933665725 0.5603038671042055 0.16663102511587544 1.659574470782877e-06 2.5933267127234246e-07 0.1613400944062976 0.053779932102929015 8.851640782279755e-11 10.052976218947128 -0.3990234445759504 FSMGSVVAGLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSMGSVVAGLLK 12 0 Q9H845;H0Y8Z9 Q9H845 ACAD9 Acyl-CoA dehydrogenase family member 9, mitochondrial 0 8475800.0 1734700.0 4655700.0 2085400.0 False True 2245603.346049097 4396606.202310789 1705878.598010962 1.0 1.9578730188686955 0.7596526790950308 21.09867168796878 -6.693830505879983 1.8531158166279937 1.5983617981468785 0.7636258561997196 0.3883114538014375 0.40480352376710005 0.40846460623075787 2.7225111854650126 0.17457518271984016 0.4523711770263239 2.023808865835418e-07 6.693830505879983 -0.8347359419471589 FSMPGFK ddPTM_RPMI8226_Bortezomib_1h_R1 2 FSMPGFK 7 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 101132600.0 20623500.0 38805200.0 41703900.0 False True 27037608.218258083 33015615.421484835 37388780.48005654 1.0 1.2210997050837469 1.382843488900341 24.688464198809584 -6.974536557258824 0.1027211037080874 0.6178585113550559 1.9901939092062475 0.9999997133654805 8.381367297226306e-05 0.07485616038714962 0.003020744090349421 0.014084142191942138 0.02600196903204465 1.0603846754638004e-07 6.974536557258824 1.3723353978511916 FSMPGFK ddPTM_RPMI8226_Bortezomib_2h_R1 2 FSMPGFK 7 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 95704040.0 31551800.0 12709440.0 51442800.0 False True 30550205.37958213 17784385.67085403 37968387.42908033 1.0 0.5821363702759267 1.242819383939594 24.864678743080702 -6.7357948417098665 1.7021689398017612 0.7501655564872753 1.2428555800840575 0.5858630339532209 0.1755949024160892 0.3254898767935738 1.8500265345979687 0.08166687752838689 0.20132977263100982 1.837406118764894e-07 6.7357948417098665 0.49269002359678216 FSMPGFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSMPGFK 7 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 149986100.0 25406000.0 117930000.0 6650100.0 False True 38542759.42739246 96884470.10870448 5335704.820157622 1.0 2.5136879545746376 0.13843598381193017 25.199956527741985 -6.734540404234046 1.7067228558430723 1.9062794016980429 0.13863702500399033 0.580207816093 0.6361211200392126 0.3277670539491751 1.8724172030921076 0.29512532535795827 0.7285859522538981 1.8427210449413001e-07 6.734540404234046 -1.7676423766940526 FSMPGFK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FSMPGFK 7 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 96706700.0 20623500.0 39191900.0 36891300.0 False True 28248565.279131465 37460272.26771801 28178334.740172863 1.0 1.3260946847233925 0.9975138369589877 24.751674260332475 -9.009924489488006 11.444213251707316 0.9999999991487235 1.16180426084124 0.2443255522973794 0.13414256937916796 0.0 0.0 0.1298829843056651 0.04329432810188836 9.774071473569013e-10 9.009924489488006 0.1618042616925165 FSMPGFK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FSMPGFK 7 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 53167220.0 31551800.0 12243000.0 9372420.0 False True 26236719.68173844 12177044.528954785 11332149.688826164 1.0 0.46412221789412117 0.4319194558728959 24.64508401851498 -13.996195993373032 0.3999672793054566 9.999421621136332 0.4300084312112477 0.9998376603172252 0.0033195691893019652 26.662138795259942 0.20828600217553997 208.20750556313448 0.008244031073652649 1.0087975216682808e-14 13.996195993373032 -9.569413189925084 FSMPGFK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FSMPGFK 7 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 62489300.0 28703900.0 16897600.0 16887800.0 False True 37157764.38845834 15957233.705815839 13814393.683460971 1.0 0.42944547306436853 0.3717767715797211 25.147160368227354 -13.999999999999998 0.3239279456440467 6.988661452902434 0.3608230294154385 0.9997021027567655 0.004893704342489763 18.323318055082183 0.18169023091913877 74.52169496899903 0.01890990723584298 1.0000000000000041e-14 13.999999999999998 -6.627838423486995 FSMPGFK(ub)GEGPDVDVNLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSMPGFKGEGPDVDVNLPK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 12836200.0 3300100.0 5954100.0 3582000.0 True False 4326463.05821386 5065771.488900025 3211369.000970231 1.0 1.1708805601107761 0.7422619719064503 22.0447566534953 -6.79851921200971 1.4619140534817792 1.0944617213192782 0.7365573936224886 0.8277954627996751 0.07310884075330476 0.22288648314013668 0.9405759987859694 0.03934430078515736 0.09158561585615328 1.5903063314285148e-07 6.79851921200971 -0.3579043276967896 FSMPGFK(ub)GEGPDVDVNLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSMPGFKGEGPDVDVNLPK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 35412000.0 15072000.0 10332000.0 10008000.0 True False 14593547.609995697 14457621.480668226 7386604.566435638 1.0 0.9906858748153623 0.5061555122742232 23.798827301216775 -6.9110617253838456 0.8884763177369381 1.0145029445054679 0.442095549492337 0.991316038680674 0.021492502443967488 0.10372003626177323 0.1349909413558011 0.017689096694461094 0.0491965050863025 1.2272647901350922e-07 6.9110617253838456 -0.5724073950131309 FSMPGFK(ub)GEGPDVDVNLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSMPGFKGEGPDVDVNLPK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 49666000.0 12865000.0 21704000.0 15097000.0 True False 19517145.55748268 17830751.625874 12113071.332749829 1.0 0.9135942329967339 0.6206374439886164 24.218238733957048 -6.948672455523521 0.5732316557576852 1.003598017991504 0.5163110089448308 0.9990929519189536 0.004889405458012145 0.08402321708868586 0.038202421585800686 0.005161135227940039 0.024428769358546733 1.1254534698732869e-07 6.948672455523521 -0.4872870090466732 FSMPGFK(ub)GEGPDVDVNLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSMPGFKGEGPDVDVNLPK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 14735500.0 3300100.0 6472500.0 4962900.0 True False 4520236.151849191 6186523.548304752 3790765.2341338997 1.0 1.3686283947297526 0.83862106022561 22.10796671501819 -6.7197190650870136 1.7609235472911733 1.2243441818564476 0.8394937194469834 0.5109372724671072 0.15512556811775027 0.3558552769047614 2.156483931164465 0.0699605944549601 0.17564569922652165 1.9066937145601103e-07 6.7197190650870136 -0.3848504624094642 FSMPGFK(ub)GEGPDVDVNLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSMPGFKGEGPDVDVNLPK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 31786300.0 15072000.0 12477000.0 4237300.0 True False 12533035.802811949 12409783.9245094 5123299.838938409 1.0 0.9901658400852175 0.4087836274902311 23.57923257665105 -6.910570835303649 0.8918225831261573 1.0176776936314755 0.3327210720516313 0.9911354860665162 0.026024738894521244 0.10404241109361437 0.1367231088853601 0.021367065676415203 0.05921989252394912 1.2286527716669196e-07 6.910570835303649 -0.6849566215798442 down FSMPGFK(ub)GEGPDVDVSLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSMPGFKGEGPDVDVSLPK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 3431350.0 720050.0 1567000.0 1144300.0 True False 986271.9436195896 1497764.7586239532 874039.9075982637 1.0 1.5186123546485564 0.8862057906570499 19.911625968522582 -6.688799881849675 1.8708890485142213 1.3255118178199887 0.8884372748366316 0.3646729587633154 0.21939188058034234 0.4192799162724187 2.8444783490930763 0.09384848516522475 0.24473950494750848 2.047387833335832e-07 6.688799881849675 -0.43707454298335713 FSMPGFK(ub)GEGPDVDVSLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSMPGFKGEGPDVDVSLPK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 8558500.0 3949900.0 3354400.0 1254200.0 True False 3284516.8602393134 3336329.1814037315 1516447.4212344058 1.0 1.015774716151295 0.46169573357705823 21.647249740602675 -6.900346008127481 0.9590651876019305 1.0228183827521493 0.4031227885663078 0.9867380290036628 0.02966050985781471 0.11115147271532638 0.1759814653311959 0.023179586068320768 0.06041553698984253 1.2579228088022055e-07 6.900346008127481 -0.6196955941858415 down FSMPGFK(ub)GEGPEVDVNLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSMPGFKGEGPEVDVNLPK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 11304000.0 4659200.0 3679800.0 2965000.0 True False 4511296.246317135 5149163.329903498 2188377.5519066444 1.0 1.141393304442619 0.48508841637105066 22.105110596915324 -6.850317642652248 1.2334243495200263 1.0754806236103718 0.45867261773862056 0.9407764133108554 0.06863423306984152 0.15711569759912067 0.45978541601659184 0.04353633573217907 0.10077443800210147 1.4115047934645866e-07 6.850317642652248 -0.6168080058717512 down FSMPGFK(ub)GEGPEVDVNLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSMPGFKGEGPEVDVNLPK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 29884800.0 4719800.0 11318000.0 13847000.0 True False 7160281.6635994315 9298214.472062392 11110134.380644295 1.0 1.2985822218882148 1.5516337069705852 22.7715849091441 -6.973042025638606 0.17052475515529406 0.777997376518532 2.0789986418551654 0.999997425664922 0.00036169702313997086 0.07532739284802972 0.005322062482314916 0.010612987784288461 0.0292669345728107 1.0640400486309724e-07 6.973042025638606 1.3010012653366334 FSMPGFK(ub)GEGPEVDVNLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSMPGFKGEGPEVDVNLPK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 32069800.0 4719800.0 10379000.0 16971000.0 True False 6109874.141167077 9801399.526125748 13882452.13716504 1.0 1.604190086353159 2.2721338961187314 22.54271123123655 -6.969832847228594 0.2621463639347555 0.8173207787935193 3.078875860953101 0.9999810499513038 0.00226173993914573 0.07635697510078358 0.009223966345268826 0.013752567648629003 0.06282089185310294 1.0719317946914591e-07 6.969832847228594 2.261555082159582 FSMPGFK(ub)GEGPEVDVTLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSMPGFKGEGPEVDVTLPK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 10570000.0 2474000.0 5537900.0 2558100.0 True False 2057240.6167832217 5508066.233512909 3092986.8826819723 1.0 2.677404961081085 1.5034638425126383 20.972279112014636 -10.495462776944951 5.414383217130912 0.9979777572861993 2.0904344017961534 0.5349681320276125 0.47925945476081777 0.011713575935516066 0.0010915227202808904 0.4646037651306125 0.154680323900089 3.1954882359768376e-11 10.495462776944951 1.0924566445099542 FSMPSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSMPSLK 7 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5966680.0 839180.0 2467200.0 2660300.0 False True 1100173.1066306795 2099103.377070278 2385037.675399528 1.0 1.9079755398665026 2.1678749107981683 20.069299111645865 -10.586435140644262 0.26159498807329723 8.447833510244151e-10 2.2868411290489963 0.9991437375955772 0.014650146996475091 2.2545776864710243 0.1305772493384347 1.5699923244095526 0.11129404701026488 2.5915814300734456e-11 10.586435140644262 2.286841128204213 FSMPSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSMPSLK 7 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5111580.0 839180.0 1867300.0 2405100.0 False True 1149447.523986789 1784796.5116646527 1837064.9145893422 1.0 1.5527429259877774 1.5982155568247205 20.132509173168756 -11.536183979247978 0.41327375425166035 2.739604296478872e-10 1.6005469041581037 0.999699738003213 0.0047118096716479265 4.094336607669937 0.2067813058324648 3.659736370264736 0.01121459161041868 2.9094843183052104e-12 11.536183979247978 1.6005469038841433 FSMVVQDGIVK ddPTM_RPMI8226_Bortezomib_1h_R1 2 FSMVVQDGIVK 11 0 P30044-2;P30044;P30044-3;P30044-4 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 115596400.0 34789200.0 39708000.0 41099200.0 False True 45608978.09909201 33783721.18057174 36846649.03536458 1.0 0.7407252385083435 0.8078814867395184 25.442814510182508 -10.547091510219055 5.365270946281448 1.0008385873891064 0.7743033626239305 0.9377322989312035 0.02741642353434599 0.0002760047569203688 2.3298870853128175e-05 0.026641610996942885 0.008848612646757304 2.837321113330635e-11 10.547091510219055 -0.22653522476517585 FSMVVQDGIVK ddPTM_RPMI8226_Bortezomib_2h_R1 2 FSMVVQDGIVK 11 0 P30044-2;P30044;P30044-3;P30044-4 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 88438800.0 29621900.0 18886900.0 39930000.0 False True 28681568.99870831 26428537.66388235 29471135.125676986 1.0 0.9214467194968508 1.0275286936709855 24.773620611708147 -6.70837414880117 1.8011224417847667 0.9516269375831068 1.0272664489085963 0.4573306681832532 0.03311045913718094 0.3783479052808047 2.391565808555759 0.01463526021182926 0.03725223732156752 1.9571578370216187e-07 6.70837414880117 0.07563951132548952 FSMVVQDGIVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSMVVQDGIVK 11 0 P30044-2;P30044;P30044-3;P30044-4 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 128054000.0 14660000.0 88824000.0 24570000.0 False True 22240291.7895605 72972663.21492039 19713728.73058643 1.0 3.281101880559564 0.8863970363842065 24.406672380357058 -6.657164704922841 1.9828311938930958 2.4717126195634815 0.8963909085942356 0.2236929874729704 0.9718992644556427 0.49118582249020476 3.7092701737701543 0.3964109899227104 1.0771745991389992 2.2020911679822906e-07 6.657164704922841 -1.575321710969246 FSMVVQDGIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FSMVVQDGIVK 11 0 P30044-2;P30044;P30044-3;P30044-4 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 113331100.0 34789200.0 38982300.0 39559600.0 False True 47651707.38277985 37259933.08877254 30216437.235536393 1.0 0.7819223095086276 0.634110274219804 25.5060245717054 -7.932087991036628 0.08348614195809649 1.5543998218303614 4.5904246568717534e-07 0.9999958494593124 0.00030612786390046197 0.1183008498212496 0.012729632149365037 0.1070875164412787 0.12222753294533824 1.1692624664351312e-08 7.932087991036628 -1.5543993627878958 FSMVVQDGIVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSMVVQDGIVK 11 0 P30044-2;P30044;P30044-3;P30044-4 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 52174000.0 24648000.0 15581000.0 11945000.0 False True 20495904.09154118 15497062.060413633 14442644.272560177 1.0 0.7561053170037711 0.7046600241714036 24.28883229407762 -13.999999999999998 0.21872847302489942 2.463614638722044 0.676804296691125 0.9994966492543104 0.0028901869450402907 12.965333573015107 0.14816934061882658 8.190960690622452 0.028711730889688557 1.0000000000000041e-14 13.999999999999998 -1.786810342030919 FSNLVLQALLVLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSNLVLQALLVLLK 14 0 I3L0N3;P46459;P46459-2;I3L2G1;K7EQD6 I3L0N3 NSF Vesicle-fusing ATPase 0 381166000.0 81816000.0 194290000.0 105060000.0 False True 124120853.5507969 159617431.50530145 84294844.95056623 1.0 1.2859839981681842 0.6791352342422321 26.887170282196987 -6.7785451932011505 1.5414067560947706 1.1622381264994819 0.6745348493175474 0.7622425232575759 0.12086789026801703 0.25284689080365735 1.1864719964971329 0.06176511186152109 0.14592600009667003 1.6651555406997284e-07 6.7785451932011505 -0.4877032771819345 FSNLVLQALLVLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSNLVLQALLVLLK 14 0 I3L0N3;P46459;P46459-2;I3L2G1;K7EQD6 I3L0N3 NSF Vesicle-fusing ATPase 0 181869000.0 81816000.0 22753000.0 77300000.0 False True 105912424.83446878 21486775.54850554 63232193.16497897 1.0 0.20287303951436636 0.5970233734503292 26.658296604289436 -10.711598520072167 6.351745658049545 1.0088376315260381 0.39994820651048696 0.7555156559406311 0.16091120001511758 0.020098399463340872 0.0009125684015845868 0.1554949535784012 0.05193386648973342 1.9426809430159e-11 10.711598520072167 -0.6088894250155512 FSNNIISTFQNLYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSNNIISTFQNLYR 14 0 A0A0A0MT33;Q9UPN6;Q9UPN6-2 A0A0A0MT33 SCAF8 Protein SCAF8 0 8581200.0 1975500.0 2636600.0 3969100.0 False True 2589899.630769216 2243229.5573863056 3558415.6062956364 1.0 0.8661453636023929 1.3739588839737258 21.30446475797063 -6.836638740838779 1.2979483852688956 0.9287336477118494 1.3895766052302159 0.9185130344436218 0.06134509671325234 0.17276181884954125 0.5668128470603017 0.03708012249000802 0.0853622761384194 1.4566702787353944e-07 6.836638740838779 0.46084295751836646 FSNNIISTFQNLYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSNNIISTFQNLYR 14 0 A0A0A0MT33;Q9UPN6;Q9UPN6-2 A0A0A0MT33 SCAF8 Protein SCAF8 0 30647400.0 12853000.0 6528400.0 11266000.0 False True 12444988.55037649 9135224.165156258 8315096.627244598 1.0 0.7340484186206742 0.6681481942378362 23.569061567224526 -13.999999992645288 0.19593966290173429 2.456139947228021 0.6235957082991185 0.9994872225453966 0.0032483400938718866 12.453529378117834 0.14037022050431058 6.938414429400528 0.04326867702457304 1.0000000169348513e-14 13.999999992645288 -1.8325442389289028 FSNNIISTFQNLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSNNIISTFQNLYR 14 0 A0A0A0MT33;Q9UPN6;Q9UPN6-2 A0A0A0MT33 SCAF8 Protein SCAF8 0 14505000.0 1975500.0 4032100.0 8497400.0 False True 2705895.735880151 3853948.489628357 6490489.129446379 1.0 1.4242782670910181 2.398647162705701 21.367674819493523 -6.957254368860596 0.472546509704545 0.9748908913503391 2.8881503117943828 0.9996544069240157 0.010885101141144934 0.0806969682038066 0.02486929431682209 0.013537541696143535 0.08040626654050956 1.1034321438298804e-07 6.957254368860596 1.9132594204440436 up FSNNIISTFQNLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSNNIISTFQNLYR 14 0 A0A0A0MT33;Q9UPN6;Q9UPN6-2 A0A0A0MT33 SCAF8 Protein SCAF8 0 21826200.0 12853000.0 3684100.0 5289100.0 False True 10687838.98444412 3664253.022063406 6395026.355964677 1.0 0.34284320968875315 0.5983460609083349 23.349466842658803 -10.310528645400453 5.7228170307129105 1.0000599887658954 0.47059463529862683 0.8512860796395905 0.10430860221904992 7.984545797677625e-05 9.61972976206429e-06 0.10100775020435028 0.033665456605044296 4.891829983071655e-11 10.310528645400453 -0.5294653534672686 FSNQYK(ub)ATIGADFLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSNQYKATIGADFLTK 16 1 P51149;C9J8S3;C9J4V0;C9J4S4;C9J592;C9IZZ0;C9J7D1 P51149 RAB7A Ras-related protein Rab-7a 1 15156900.0 7183500.0 4849700.0 3123700.0 True False 6955463.724549094 6786210.500851401 2305509.2610086952 1.0 0.9756661481677606 0.331467369008262 22.729715272561148 -6.914883558418342 0.8618230156910641 1.0169992529408727 0.2388985014674437 0.9926374513958446 0.02656301883958699 0.10127660768624416 0.1219082313972021 0.022286889181202182 0.06381630799989813 1.2165121240804034e-07 6.914883558418342 -0.7781007514734289 down FSNTGEDWYVLVGVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSNTGEDWYVLVGVAK 16 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 38221400.0 6061400.0 16540000.0 15620000.0 False True 9195586.947697269 13588307.772390144 12532700.153510788 1.0 1.477698797224998 1.3629037738204617 23.132510233086634 -10.06502865515692 4.945028096791583 0.9999899977160445 1.4203012855257755 0.9470161698497539 0.046864872069201785 5.1680456338489245e-06 9.771654360279694e-07 0.04537779651126912 0.015125572419007853 8.609369448840604e-11 10.06502865515692 0.42031128780973104 FSNTGEDWYVLVGVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSNTGEDWYVLVGVAK 16 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 24988900.0 6061400.0 9212200.0 9715300.0 False True 7846601.788056719 8699532.971825372 7947215.087396116 1.0 1.108700709785846 1.0128225315948287 22.903636555179084 -10.733947641774202 3.3600700354085786 0.9922433393374627 1.0607616206961255 0.34874550139447513 0.039142102357489286 0.002557312831414591 0.00020248953650092816 0.04261326731326149 0.012633059231191311 1.8452378663007114e-11 10.733947641774202 0.06851828135866278 FSNVYHLSIHISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSNVYHLSIHISK 13 0 Q9GZP4-2;Q9GZP4;X6R8S9;X6RHB9 Q9GZP4-2 PITHD1 PITH domain-containing protein 1 0 22490900.0 6354200.0 6428000.0 9708700.0 False True 6152489.399113228 8994733.921577157 7165700.215243178 1.0 1.461966585895067 1.1646830657320575 22.5527388362116 -10.177901476504388 4.82407752652069 0.999966111733714 1.313324825813203 0.5969542373484673 0.12136548889361462 4.4247219394890525e-05 7.54043085140289e-06 0.11752432457203443 0.039170543106873824 6.638936633944584e-11 10.177901476504388 0.3133587140794891 FSNVYHLSIHISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSNVYHLSIHISK 13 0 Q9GZP4-2;Q9GZP4;X6R8S9;X6RHB9 Q9GZP4-2 PITHD1 PITH domain-containing protein 1 0 102399800.0 19170800.0 36699000.0 46530000.0 False True 29083505.17321325 30149776.71940429 37333325.10517648 1.0 1.0366624153395756 1.2836597543119235 24.793697819000986 -6.933434480929002 0.7180327174246085 0.9966803914341674 1.3391084375341789 0.997171409784027 0.0066996176630624415 0.09089300583494478 0.06922631690790423 0.006233567023781787 0.021942182904895625 1.1656428902316733e-07 6.933434480929002 0.34242804610001143 FSNVYHLSIHISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSNVYHLSIHISK 13 0 Q9GZP4-2;Q9GZP4;X6R8S9;X6RHB9 Q9GZP4-2 PITHD1 PITH domain-containing protein 1 0 11365810.0 6354200.0 4070800.0 940810.0 False True 5283798.838788987 4048869.792409461 1137529.021186048 1.0 0.7662800791518088 0.21528620901221937 22.333144111645876 -7.052638561856015 0.5119706323184603 1.009370971609254 1.4250228831399781e-11 0.9995163810872548 0.007234501391402724 0.07411355541333405 0.029104858257342405 0.008447057220387954 0.041130860967556665 8.858525469015935e-08 7.052638561856015 -1.0093709715950039 down FSNVYHLSIHISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSNVYHLSIHISK 13 0 Q9GZP4-2;Q9GZP4;X6R8S9;X6RHB9 Q9GZP4-2 PITHD1 PITH domain-containing protein 1 0 60544500.0 19170800.0 35209000.0 6164700.0 False True 24816978.51296363 33249588.198801585 5042787.855163598 1.0 1.3397919566007206 0.20319910631060104 24.564824141093435 -6.826570924289848 1.343128534649386 1.1820371208288842 0.1746945165023454 0.8988475039869755 0.15150099896174152 0.18508071278250035 0.6541799630235177 0.0885928304827945 0.20393288020736186 1.4908332687643074e-07 6.826570924289848 -1.0073426043265388 down FSPAGPILSIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSPAGPILSIR 11 0 P11940;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YBN4;E5RJB9;Q4VXU2;E5RH24;Q4VXU2-2;E5RHG7;E5RGC4;E5RFD8 P11940 PABPC1;PABPC3;PABPC1L Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like 0 95691000.0 27604000.0 28342000.0 39745000.0 False True 36189111.3175163 24113484.076250736 35632568.660960905 1.0 0.6663187682251622 0.9846212676605294 25.10905234463395 -10.625541512878312 9.137129895437695 1.0000661293427462 0.8254700181822175 0.28615561579423476 0.12994645124486337 0.0001751193734536869 7.176676028556667e-06 0.12586754133592506 0.041940036797509135 2.368418731077083e-11 10.625541512878312 -0.17459611116052864 FSPAGPILSIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSPAGPILSIR 11 0 P11940;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YBN4;E5RJB9;Q4VXU2;E5RH24;Q4VXU2-2;E5RHG7;E5RGC4;E5RFD8 P11940 PABPC1;PABPC3;PABPC1L Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like 0 62773000.0 26327000.0 11335000.0 25111000.0 False True 25491263.79567122 15861124.611244112 18533675.786147635 1.0 0.6222180562870938 0.7270599031380671 24.603499564701902 -10.213425178683062 7.849079151719497 1.0000002180105396 0.6746389797125817 0.9277511319827216 0.042801504745983994 1.6331216799448783e-07 1.6364773476817056e-08 0.04144240655709735 0.01381412625615114 6.117511878692525e-11 10.213425178683062 -0.32536123829795793 FSPAGPVLSIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSPAGPVLSIR 11 0 B1ANR0;Q13310-2;Q13310;Q13310-3;B1ANR1 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 22184900.0 6552900.0 6830000.0 8802000.0 False True 8590915.35837387 5810990.623131482 7891253.474745957 1.0 0.6764111134522242 0.9185579353955656 23.0343804274202 -10.497888890252309 5.44291649508263 1.0003745496318948 0.7974845244238943 0.48256362149812027 0.09885602609962867 0.00045013089281786725 4.152470949923581e-05 0.09589184904202247 0.03190564522967535 3.17768694497434e-11 10.497888890252309 -0.20289002520800048 FSPAGPVLSIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSPAGPVLSIR 11 0 B1ANR0;Q13310-2;Q13310;Q13310-3;B1ANR1 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 13704900.0 5188300.0 2977300.0 5539300.0 False True 5023600.256431832 4166151.41641439 4088391.154562051 1.0 0.8293158698446138 0.8138368791043015 22.26029023836899 -13.999999999999998 0.3396948155245288 2.9704695965286954 0.8113972008523699 0.9997345896489968 0.001374116283313324 19.67580682141977 0.18693844049966513 27.83614967986456 0.004787679145970368 1.0000000000000041e-14 13.999999999999998 -2.1590723956763256 FSPAGPVLSIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSPAGPVLSIR 11 0 B1ANR0;Q13310-2;Q13310;Q13310-3;B1ANR1 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 28622700.0 6552900.0 7603800.0 14466000.0 False True 8975684.215463944 7267838.973595927 11049428.73662193 1.0 0.8097253422835865 1.2310402718474867 23.09759048894309 -6.783966591155221 1.520780321465407 0.8928145666946024 1.234779915201898 0.7810445369425567 0.08060940460545699 0.24446779736032234 1.1170235167421185 0.04174100996710825 0.09815474142190585 1.6444982241838534e-07 6.783966591155221 0.34196534850729554 FSPAGPVLSIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSPAGPVLSIR 11 0 B1ANR0;Q13310-2;Q13310;Q13310-3;B1ANR1 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 11694000.0 5188300.0 3257800.0 3247900.0 False True 4314301.330661435 3240249.5847773314 3927020.873407129 1.0 0.7510485096970642 0.9102333315241727 22.040695513803268 -10.751947688404853 5.422682108795739 1.0076506732123338 0.8306409206106234 0.6014696903555592 0.0649869313787118 0.0062261834358248 0.00028480700700046725 0.06517664849136814 0.020974441912572903 1.770322184144671e-11 10.751947688404853 -0.17700975260171037 FSPDSTLLATCSADQTCK(ub)IWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSPDSTLLATCSADQTCKIWR 21 1 A0A0A0MR05;Q9BVC4-3;Q9BVC4-5;Q9BVC4;H3BSZ4 A0A0A0MR05 MLST8 Target of rapamycin complex subunit LST8 1 71897100.0 7343600.0 9475500.0 55078000.0 True False 11140778.089073427 7784522.992580592 44191809.15845498 1.0 0.6987414101906797 3.9666716996900875 23.409346660448417 -6.884358732451702 1.0552326808853085 0.7999365632258019 4.218490213263497 0.9770329149888182 0.22348127730244896 0.12383735835193384 0.24957041137127003 0.1624532877710883 0.3975716263077396 1.305092420784663e-07 6.884358732451702 3.418553650037695 up FSPGFFPGTGDVSDVGLGK(ub)GR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSPGFFPGTGDVSDVGLGKGR 21 1 A0A3B3IT84;A0A3B3ISS7;A0A3B3IRI9;A0A3B3IS68;A0A3B3IRP8;E7EVA8;A0A3B3IU62;A0A3B3IT30;A0A3B3IT95;A0A3B3ITZ3;A0A3B3ISE4;A0A3B3ISJ4;A6NGJ7;A0A3B3IRV1;Q9BY41-4;Q9BY41;A0A3B3IT04;A0A3B3IRZ0;A0A3B3IRZ8;A6NMT1;Q9BY41-5 A0A3B3IT84 HDAC8 Histone deacetylase 8 1 8456200.0 2403100.0 2032300.0 4020800.0 True False 1998284.1253806662 2021351.596520032 4861530.689921303 1.0 1.0115436392885178 2.432852579957917 20.930330296165767 -6.908679539822371 0.9046796884771761 0.9541346224749745 2.611438168329385 0.9904136595240947 0.06586874264464403 0.10529770105805736 0.14355152360547796 0.053577986587295616 0.14658079883724395 1.2340150608239533e-07 6.908679539822371 1.6573035458544103 up FSPLMTAAVLGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSPLMTAAVLGTR 13 0 Q6P996;Q6P996-5;Q6P996-4;Q6P996-3;H3BND4 Q6P996 PDXDC1 Pyridoxal-dependent decarboxylase domain-containing protein 1 0 808600.0 0.0 808600.0 0.0 False True 0.0 1131478.1967932945 0.0 0.0 FSPLMTAAVLGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSPLMTAAVLGTR 13 0 Q6P996;Q6P996-5;Q6P996-4;Q6P996-3;H3BND4 Q6P996 PDXDC1 Pyridoxal-dependent decarboxylase domain-containing protein 1 0 4925900.0 1893400.0 1721200.0 1311300.0 False True 2593441.147211073 1645151.692752744 1001597.9470712246 1.0 0.634350887245659 0.38620423222185707 21.306436200413568 -8.187838620779074 0.17359643546073908 1.3245537925448967 4.386374239265053e-13 0.999880825401747 0.002752173006984905 0.08607371588625792 0.034902976290410996 0.11021686689929071 0.11993641520584584 6.488755040075497e-09 8.187838620779074 -1.3245537925444582 down FSPNSSNPIIVSCGWDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSPNSSNPIIVSCGWDK 17 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RBD0;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 68493000.0 14681000.0 27115000.0 26697000.0 False True 19246933.171006236 23069547.69344219 23934650.53570697 1.0 1.1986090193420724 1.2435565875898793 24.198125247605347 -13.679323057757607 0.21251151495480283 1.765253484268224e-07 1.2697214513461303 0.9994767219345964 0.0024207118726312198 11.163464322079934 0.14441794212899178 4.669753624411995 0.026180177089765867 2.0925552918890866e-14 13.679323057757607 1.269721274820782 FSPNSSNPIIVSCGWDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSPNSSNPIIVSCGWDK 17 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RBD0;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 16921500.0 11789000.0 1495300.0 3637200.0 False True 11414764.647972353 2092381.0878864853 2684508.2063389 1.0 0.18330479448458561 0.23517858572894532 23.444397778289833 -10.00425902982374 6.094463692095531 1.0000006753619295 0.20924169010673577 0.9967828574327826 0.021177386595585976 1.9433715941157346e-07 3.168549065337485e-08 0.020504933814434405 0.006834972133379523 9.902411510638903e-11 10.00425902982374 -0.7907589852551937 FSPNSSNPIIVSCGWDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSPNSSNPIIVSCGWDK 17 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RBD0;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 129019700.0 8311700.0 110110000.0 10598000.0 False True 12609456.566663709 90460010.20664328 8503300.65473158 1.0 7.173981664348425 0.6743590106184439 23.588002764978906 -6.6578121879981795 1.9806359938315432 4.981304755142591 0.7015566031939248 0.22630730182679137 2.6301335381767665 0.48968348716185395 3.690471372138503 1.0737128262588658 2.91500524009687 2.1988105496814094e-07 6.6578121879981795 -4.279748151948666 FSPNSSNPIIVSCGWDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSPNSSNPIIVSCGWDK 17 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RBD0;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 71283000.0 14681000.0 24297000.0 32305000.0 False True 20108962.43910729 23223478.20056552 24675224.342359453 1.0 1.1548819721996801 1.2270759576521877 24.26133530912824 -13.999999999999998 0.10204149371170369 0.23947404161266744 1.3760884549528885 0.9997834494790451 0.001394001512591609 12.065266225746722 0.09553864784135131 1.9225738839896467 0.13275355132437994 1.0000000000000041e-14 13.999999999999998 1.136614413340221 FSPNSSNPIIVSCGWDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSPNSSNPIIVSCGWDK 17 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RBD0;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 18914500.0 11789000.0 0.0 7125500.0 False True 9803075.841251997 0.0 8615409.105410434 1.0 0.0 0.8788475418252114 23.22480305372411 -9.094005000415365 11.979150313837138 1.0000031651255346 0.4394237708759827 0.35169194682895966 0.35878800653318255 0.0 0.0 0.3473949935283826 0.1157983311761275 8.053691682202119e-10 9.094005000415365 -0.5605793942495518 FSPNSSNPIIVSCGWDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSPNSSNPIIVSCGWDK 17 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RBD0;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 30123700.0 8311700.0 11681000.0 10131000.0 False True 10759659.498101272 11030942.08157575 8287261.9528383305 1.0 1.0252129338779123 0.7702160049117504 23.359129087071356 -6.882592152033364 1.065278257374913 1.0162317926160152 0.751224705753444 0.9757151858179225 0.017878522765274678 0.12535686864202006 0.2586432147624117 0.012897049911663617 0.03140314876197777 1.3104119593046197e-07 6.882592152033364 -0.26500708686257113 FSPNSSNPIIVSCGWDK(ub)LVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSPNSSNPIIVSCGWDKLVK 20 1 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RBD0;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 130594300.0 8374300.0 14310000.0 107910000.0 True False 12704425.343336735 11756268.695459686 86581541.20136674 1.0 0.9253680019164077 6.81506946292359 23.59882778395005 -6.9040299217392755 0.9354262832003704 0.7814604416479217 7.486514657187046 0.9884671233540346 0.29629339664069315 0.10849984254939485 0.1611572843594495 0.23563557030493137 0.6264675634461556 1.2472975757838647e-07 6.9040299217392755 6.705054215539124 up FSPNSSNPIIVSCGWDK(ub)LVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSPNSSNPIIVSCGWDKLVK 20 1 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RBD0;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 92401200.0 8374300.0 9211900.0 74815000.0 True False 10840696.432131756 8699249.667089095 61199437.666725844 1.0 0.8024622515306834 5.64534188830628 23.3699541060425 -6.897391887525528 0.9776288774711479 0.783990060846708 6.127561730308363 0.9852228507959533 0.27203580609939276 0.11334991795798426 0.18845352366591595 0.2096821551216962 0.5387457735777477 1.2665085105848564e-07 6.897391887525528 5.343571669461655 up FSPNTSQFLLVSSWDTSVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSPNTSQFLLVSSWDTSVR 19 0 O43684-2;O43684;J3QT28;J3QSX4 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 37387100.0 7621100.0 16301000.0 13465000.0 False True 11561765.87704089 13391959.189705698 10803636.848080834 1.0 1.1582970397540369 0.934427920698037 23.46285842774955 -6.716701044616517 1.770861287264206 1.0966397971759787 0.934831476737596 0.49710048264722717 0.06663995757519169 0.3617423592258956 2.215091520225911 0.029899013669978217 0.07535971627040526 1.919989949761541e-07 6.716701044616517 -0.16180832043838267 FSPNTSQFLLVSSWDTSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSPNTSQFLLVSSWDTSVR 19 0 O43684-2;O43684;J3QT28;J3QSX4 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 23605000.0 7621100.0 7507700.0 8476200.0 False True 9865664.184340095 7089889.895201291 6933618.573156462 1.0 0.7186429380451821 0.7028030189961554 23.233984749841998 -13.999999999999998 0.4097514784926018 6.05038417438418 0.7020814068309972 0.9998510974113766 0.0016658809270348489 28.26575232858533 0.2121650398463703 127.36868561208126 0.003947454023303117 1.0000000000000041e-14 13.999999999999998 -5.348302767553183 FSPSQQEK(ub)LFGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSPSQQEKLFGEK 13 1 F8W9S7;Q14C86-3;Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;B0QZ65;B4DGD8;C9IZ08;A0A0A0MQV8;H0Y4E7;H0Y7I9 F8W9S7 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 4897100.0 1285200.0 1934900.0 1677000.0 True False 1068700.7440136625 1924476.3096524223 2027652.9464280803 1.0 1.8007625805749599 1.8973065732254777 20.02742649762232 -11.111514081886224 0.37918941492716135 1.7788968109648274e-09 1.9079832307234983 0.9994949351385096 0.009038331282896045 3.0341748904818893 0.18842989563061466 2.6296528210878605 0.02617229654726342 7.735455963524501e-12 11.111514081886224 1.9079832289446015 FSQLPFK(ub)VEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSQLPFKVEAK 11 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 3143980.0 1278900.0 798680.0 1066400.0 True False 1751743.890972978 763391.6767184299 814538.2831974024 1.0 0.43578954700644984 0.4649870836683667 20.74036043431358 -10.71732347838192 6.7985513319609545 1.0065805938702106 0.45038831533750856 0.9978878555663445 0.011919844427983535 0.0011905126101755515 4.950018326948684e-05 0.011556765069685324 0.003847113246580288 1.9172401782493737e-11 10.71732347838192 -0.556192278532702 FSQMLQDKPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSQMLQDKPLR 11 1 Q9H6F5 Q9H6F5 CCDC86 Coiled-coil domain-containing protein 86 0 11196600.0 8093200.0 1536700.0 1566700.0 False True 11085474.750506317 1468803.5128126526 1196677.7271993344 1.0 0.1324980251969422 0.10795006566089355 23.402167221113608 FSQWLDDHPSEK(ub)DR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSQWLDDHPSEKDR 14 1 Q9UP83-3;Q9UP83;Q9UP83-2 Q9UP83-3 COG5 Conserved oligomeric Golgi complex subunit 5 1 10664240.0 4174100.0 698240.0 5791900.0 True False 4041595.480286825 977050.8732734965 4274827.636724481 1.0 0.2417488039164565 1.0577079417213482 21.946493500198404 -12.00398198706296 14.694988606742044 0.9420136962226294 0.684755535611739 0.0 0.380669381431238 0.0 0.0 0.0 0.11064949720733258 9.908730418081537e-13 12.00398198706296 -0.25725816061089046 FSQWLDDHPSEK(ub)DR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSQWLDDHPSEKDR 14 1 Q9UP83-3;Q9UP83;Q9UP83-2 Q9UP83-3 COG5 Conserved oligomeric Golgi complex subunit 5 1 25233240.0 3956640.0 6589600.0 14687000.0 True False 6002512.149130054 5413634.395220209 11784108.012459224 1.0 0.9018947835040715 1.9631960285439987 22.51713498780851 -6.8842868928353145 1.0555718161539054 0.93492352627897 2.044886413531125 0.9769832068817781 0.07264868429976765 0.1239017969806949 0.24989814122504214 0.052794083063742885 0.12918352232007033 1.3053083228919075e-07 6.8842868928353145 1.1099628872521548 FSQWLDDHPSEK(ub)DR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSQWLDDHPSEKDR 14 1 Q9UP83-3;Q9UP83;Q9UP83-2 Q9UP83-3 COG5 Conserved oligomeric Golgi complex subunit 5 1 10996200.0 4174100.0 4094100.0 2728000.0 True False 3470949.0939833694 4072044.2706847796 3298412.187153129 1.0 1.1731789088302573 0.950291144537579 21.72689877563268 -6.699285544719829 1.833128502800571 1.107609044191552 0.9509561413940297 0.4143499981456007 0.0731101108916677 0.3969939937136229 2.593003614783249 0.031821639213319985 0.08191790540586472 1.9985474105915543e-07 6.699285544719829 -0.1566529027975223 FSQWLDDHPSEK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSQWLDDHPSEKDR 14 1 Q9UP83-3;Q9UP83;Q9UP83-2 Q9UP83-3 COG5 Conserved oligomeric Golgi complex subunit 5 1 37188240.0 3956640.0 6214600.0 27017000.0 True False 5121948.477034469 5868752.046927546 22100183.21782972 1.0 1.1458045845719762 4.3147999861617885 22.28826130990096 -6.916514549984422 0.8501827456014255 0.9209159114195696 4.786981858559535 0.9931565572466132 0.12652010537483596 0.10026607189090048 0.11656412677621683 0.10704395253059622 0.3106972833482106 1.2119520845764376e-07 6.916514549984422 3.866065947139966 up FSSELEQIELHNSIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSSELEQIELHNSIR 15 0 D6RA57;H0Y9X1;Q96EY4 D6RA57 TMA16 Translation machinery-associated protein 16 0 5318800.0 1607100.0 1217900.0 2493800.0 False True 2106923.663178537 1036194.0673370167 2235765.498218752 1.0 0.4918042762753913 1.0611516388998365 21.006706613546392 -6.671320135644997 1.9326813059951662 0.6759911341251318 1.0588650830076938 0.284929528698426 0.2158046634612154 0.4580830373961476 3.300008637008982 0.08985268646536541 0.2396523990784458 2.1314731407284957e-07 6.671320135644997 0.382873948882562 FSSELEQIELHNSIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSSELEQIELHNSIR 15 0 D6RA57;H0Y9X1;Q96EY4 D6RA57 TMA16 Translation machinery-associated protein 16 0 4539900.0 1607100.0 1435500.0 1497300.0 False True 2201288.300244487 1372074.863436303 1143668.5778614697 1.0 0.6233053904315546 0.5195451126208447 21.069916675069283 -13.999999999999956 0.1809131259876173 2.9600023681967276 0.437895293393697 0.9994970649986961 0.004629329688250368 12.21667563127775 0.13484317666792858 8.41869110849573 0.0768740561865813 1.0000000000001022e-14 13.999999999999956 -2.5221070748030305 FSSLCFFNDHVGFHGTIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSSLCFFNDHVGFHGTIK 18 0 F8VWC0;F8VZA0;Q9H0K6 F8VWC0 PUS7L Pseudouridylate synthase 7 homolog-like protein 0 22125700.0 5655600.0 4431100.0 12039000.0 False True 8579958.679743405 3640335.5846576765 9659486.373118857 1.0 0.4242835799725023 1.12581968441458 23.03253926918503 -6.68858857658037 1.871303034681569 0.6386028865646439 1.1233691146193157 0.3640117725497575 0.24355456584967475 0.41963693123411516 2.8479064966008316 0.10416080054124847 0.27173833431408884 2.048384228912584e-07 6.68858857658037 0.48476622805467173 FSSLCFFNDHVGFHGTIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSSLCFFNDHVGFHGTIK 18 0 F8VWC0;F8VZA0;Q9H0K6 F8VWC0 PUS7L Pseudouridylate synthase 7 homolog-like protein 0 22012700.0 5655600.0 9459300.0 6897800.0 False True 7321285.688542842 8932881.63960702 5642471.177404812 1.0 1.220124718474814 0.7706940307267035 22.80366559127748 -6.773493595809722 1.5608373176290218 1.125689722588016 0.7678095631213999 0.7438565153835861 0.0928664746477589 0.26080207093953295 1.2543354037087124 0.046882342941484224 0.11125680640435488 1.6846372685773e-07 6.773493595809722 -0.3578801594666161 FSSLK(ub)GVPTEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSSLKGVPTEVK 12 1 Q99871-3;Q99871;Q99871-2;A6NDA1 Q99871-3 HAUS7 HAUS augmin-like complex subunit 7 1 9642800.0 1034900.0 1354400.0 7253500.0 True False 1356763.921985856 1152328.7994098507 6502977.400485083 1.0 0.8493215221430862 4.793005839193354 20.37173828182015 -6.898016838103263 0.9737318761785358 0.8269952632341805 5.190669897439204 0.9855532133944337 0.2193065167936792 0.11287940117998725 0.18577217071572805 0.16953037425273007 0.43685446896937763 1.2646873131193886e-07 6.898016838103263 4.363674634205023 up FSSYYLSLPPEMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSSYYLSLPPEMR 13 0 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 5560900.0 1144600.0 1745800.0 2670500.0 False True 1500581.6843221665 1485333.4450750996 2394182.2772448375 1.0 0.9898384477123918 1.5955027988538477 20.517090423654565 -6.903088477615723 0.9415673356529044 0.9769073587624947 1.6632128544482736 0.9880401704718554 0.03096537172512167 0.10916701558693395 0.16488945633134708 0.02451543529530162 0.06483013247739623 1.25000434434153e-07 6.903088477615723 0.6863054956857789 FSSYYLSLPPEMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSSYYLSLPPEMR 13 0 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 5157700.0 1144600.0 1496600.0 2516500.0 False True 1567789.5516519444 1430475.2634056206 1922154.5289443608 1.0 0.9124153569580568 1.2260284085443929 20.580300485177457 -6.832186238930855 1.3182767703565534 0.9532684818032321 1.234840700334994 0.9101464606786525 0.03960522411973099 0.17813024837061092 0.6046760530087346 0.023584220339549666 0.054268489846749 1.471681264567568e-07 6.832186238930855 0.28157221853176184 FSTYFTHCPILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSTYFTHCPILR 12 0 Q7Z478;A0A087WYN9 Q7Z478 DHX29 ATP-dependent RNA helicase DHX29 0 14723600.0 5152500.0 4138100.0 5433000.0 False True 6754977.396880972 3520711.6101874644 4870845.277015985 1.0 0.521202574536091 0.7210749926809582 22.687519511419577 -10.226902833708861 5.509266709246847 1.0000208584324863 0.6211387836085012 0.827307439026531 0.08159757301860379 2.0906367091915916e-05 2.933679104195199e-06 0.07901085377378503 0.026335503449320913 5.93057996770195e-11 10.226902833708861 -0.37888207482398517 FSTYFTHCPILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSTYFTHCPILR 12 0 Q7Z478;A0A087WYN9 Q7Z478 DHX29 ATP-dependent RNA helicase DHX29 0 13572200.0 5152500.0 3178800.0 5240900.0 False True 7057518.491076918 3038350.1051141215 4003107.359723625 1.0 0.430512524898889 0.5672117423121033 22.75072957294247 -10.11194915198984 7.747820608869195 1.0000000659931 0.4988621336057195 0.9471439303780276 0.05580722181669264 6.358231138408035e-08 7.378618587881834e-09 0.0540351174201362 0.018011703391179485 7.727710572798971e-11 10.11194915198984 -0.5011379323873806 FSVCVLGDQQHCDEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSVCVLGDQQHCDEAK 16 0 P62906 P62906 RPL10A 60S ribosomal protein L10a 0 121631000.0 44277000.0 33994000.0 43360000.0 False True 58047575.779077925 28922227.707574144 38873523.13848945 1.0 0.4982503975299271 0.6696838346262278 25.790732481784172 -10.103730070401472 6.20486875614907 1.0000011425898876 0.5839671160780735 0.8870364161520192 0.06998740762292396 1.106203631328088e-06 1.5972972785732983e-07 0.06776520232777504 0.022588338680649016 7.875351189365984e-11 10.103730070401472 -0.4160340265118141 FSVCVLGDQQHCDEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSVCVLGDQQHCDEAK 16 0 P62906 P62906 RPL10A 60S ribosomal protein L10a 0 121948000.0 32487000.0 89461000.0 0.0 False True 49285154.117834404 73495985.58801666 0.0 1.0 1.491239845010879 0.0 25.55464980156368 -6.839260786972324 1.4310629187994532 1.2638137371538225 1.0142272973242313e-22 0.8788558513310676 0.21596762804861655 0.18510479910129618 0.7610638301520093 0.12101161044052933 0.259127053428289 1.4479021500923843e-07 6.839260786972324 -1.2638137371538225 down FSVCVLGDQQHCDEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSVCVLGDQQHCDEAK 16 0 P62906 P62906 RPL10A 60S ribosomal protein L10a 0 131078000.0 44277000.0 36220000.0 50581000.0 False True 60647403.44093409 34619680.63647707 38634809.548394494 1.0 0.5708353313129716 0.6370397965350953 25.853942543307063 -10.602271667568909 6.47571611769732 1.0010524170650075 0.6039375639240573 0.9794741330570029 0.027027859748006297 0.000411656021996304 2.5283252246089706e-05 0.02623267662041228 0.008723204223971508 2.4987817905109672e-11 10.602271667568909 -0.3971148531409502 FSVLLLHGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSVLLLHGIR 10 0 Q96IU4;F8W9U3;B4DQI4 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 304825870.0 71725000.0 103617000.0 129483870.0 False True 94032169.58588815 88157747.49590266 116086121.22938561 1.0 0.9375275279103302 1.2345362415928687 26.48665106953635 -6.851768929638409 1.2265062768031816 0.9666053721285426 1.246822319988772 0.9428458214187893 0.030566438536516263 0.155518226779286 0.449304327119604 0.01949185532984171 0.045159763001368536 1.40679582366079e-07 6.851768929638409 0.28021694786022944 FSVLLLHGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSVLLLHGIR 10 0 Q96IU4;F8W9U3;B4DQI4 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 259243000.0 108254000.0 93259000.0 57730000.0 False True 104817536.02524382 130497805.0392602 42608781.13712323 1.0 1.244999739431307 0.40650431934272435 26.64330485975536 -6.828487983569828 1.334516741399634 1.1310621235877536 0.38461020573338167 0.9028296392714419 0.1097358728257815 0.1826945556348528 0.6368430676585966 0.06456986683123402 0.1486156472855179 1.4842669474603855e-07 6.828487983569828 -0.7464519178543719 down FSVLLLHGIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSVLLLHGIR 10 0 Q96IU4;F8W9U3;B4DQI4 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 783831000.0 212390000.0 250470000.0 320971000.0 False True 322211157.7888644 205771671.56895766 257530941.1634128 1.0 0.6386236683454453 0.7992614002900712 28.263431212820425 -10.036412204538715 4.549041663775578 1.0000098063648934 0.7189425343029826 0.8032128298729122 0.06558007952130979 45362002.355771706 1.9792402779590788 5523.554047221095 0.022449805537327575 9.195763543709946e-11 10.036412204538715 -0.28106727206191084 FSVLLLHGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSVLLLHGIR 10 0 Q96IU4;F8W9U3;B4DQI4 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 362366270.0 71725000.0 121717270.0 168924000.0 False True 98243670.79524367 116339398.54621364 129027630.29898563 1.0 1.1841923006794455 1.3133429283999467 26.54986113105924 -6.974939896844219 0.07502509758000958 0.501414047906684 1.9993537772111936 0.9999999209244841 3.569264462829143e-05 0.07473141264111259 0.0021707528183249666 0.016835608004879384 0.026349142070449277 1.0594003282308852e-07 6.974939896844219 1.4979397293045096 FSVLLLHGIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSVLLLHGIR 10 0 Q96IU4;F8W9U3;B4DQI4 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 271472000.0 108254000.0 71565000.0 91653000.0 False True 90017997.46534006 71179465.14045963 110817218.54440838 1.0 0.7907248233095399 1.2310562516909656 26.423710135189637 -6.7774642606659175 1.5457436821392652 0.8811132909805751 1.2342715322993785 0.7583213542316388 0.0884097639364164 0.2545320265154253 1.201045841675704 0.0450567547195799 0.10654289730601832 1.6693051734522672e-07 6.7774642606659175 0.35315824131880336 FSVLLLHGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSVLLLHGIR 10 0 Q96IU4;F8W9U3;B4DQI4 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 806413000.0 212390000.0 334492000.0 259531000.0 False True 274943041.83280534 315877226.15790117 212299021.01293853 1.0 1.1488824159805004 0.7721563695437652 28.034557534912874 -6.799474012120161 1.4579401834544914 1.0822000167863144 0.7670159744432807 0.8306554555760326 0.06375179812652366 0.22150779688338648 0.9295792229071655 0.03440012980723622 0.08003204143321974 1.5868138699493375e-07 6.799474012120161 -0.31518404234303365 FSVLNSQHMFEVLAAMNHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSVLNSQHMFEVLAAMNHR 19 0 Q9NYY8-2;Q9NYY8 Q9NYY8-2 FASTKD2 FAST kinase domain-containing protein 2 0 10351100.0 3362700.0 2357700.0 4630700.0 False True 3255952.929148918 3299141.9052430717 3417780.751977767 1.0 1.0132646193092978 1.0497021383141276 21.634648412240896 -6.953414166933216 0.5200269556312075 0.9993809580857436 1.0652119154312942 0.9994425444411386 0.0004960956628068994 0.08214334240316687 0.03050937693867754 0.0005619883086212061 0.0030097592670106756 1.1132323880173533e-07 6.953414166933216 0.06583095734555067 FSVLNSQHMFEVLAAMNHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSVLNSQHMFEVLAAMNHR 19 0 Q9NYY8-2;Q9NYY8 Q9NYY8-2 FASTKD2 FAST kinase domain-containing protein 2 0 9109900.0 3362700.0 2821200.0 2926000.0 False True 2796234.0428686114 2806001.635635647 3537813.071704565 1.0 1.0034931241867777 1.265206351638284 21.415053687675172 -6.909808481024117 0.8970253262782328 0.9918475830303749 1.2988916339596548 0.9908493313221766 0.011881275766244212 0.1045452970556044 0.13945064103884114 0.00971814140460887 0.026791437894890753 1.2308114251295487e-07 6.909808481024117 0.3070440509292799 FSVPGFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSVPGFK 7 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5373800.0 1230900.0 1895200.0 2247700.0 False True 1613721.820052555 1612443.5474317393 2015129.5654608596 1.0 0.9992078730020679 1.2487465562033682 20.621960471719287 -6.906183827185768 0.9213291790424374 0.9913107199140991 1.2784955971754637 0.9894000457582145 0.012091922704419073 0.1069960444479978 0.15285553276131827 0.009716695060691973 0.026163669217134478 1.2411268550267532e-07 6.906183827185768 0.28718487726136455 FSVPGFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSVPGFK 7 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 4703060.0 1558800.0 825360.0 2318900.0 False True 1509316.7472439809 1154930.5521955392 1711510.5244911679 1.0 0.7652009124688026 1.133963780377044 20.525464172885666 -6.734696544500262 1.7061629499005804 0.8594418776492484 1.1339368154551734 0.5808573230835402 0.09867297726552078 0.3275107081307477 1.8697934429518996 0.04579251138297612 0.11302935984738263 1.8420586574352953e-07 6.734696544500262 0.27449493780592504 FSVSFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSVSFAK 7 0 F8W9A8;B7WPL9;Q6PFW1-5;Q6PFW1-2;Q6PFW1 F8W9A8 PPIP5K1 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 1 0 5726110.0 1628900.0 828810.0 3268400.0 False True 1577191.4611147814 1159758.1551870513 2412307.990101745 1.0 0.735331241501471 1.5294959740630927 20.588926374179582 -6.816847683216615 1.3853422547228502 0.8568706118580262 1.5457047824928958 0.8769998895661185 0.11579533038630069 0.19761247694806003 0.746026958534571 0.06569603911353612 0.15156923547043938 1.5245873669129016e-07 6.816847683216615 0.6888341706348696 FSVSGLK(ub)AEGPDVAVDLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSVSGLKAEGPDVAVDLPK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 17591500.0 7883100.0 4866400.0 4842000.0 True False 11959239.031806579 3997952.898643258 3884976.577676011 1.0 0.33429826831041454 0.3248514865656248 23.511622257763758 FSVSPVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSVSPVVR 8 0 P13639 P13639 EEF2 Elongation factor 2 0 61755000.0 8709000.0 24889000.0 28157000.0 False True 11417583.338075977 21175658.21656212 25243583.74101587 1.0 1.854653265016633 2.2109393024382133 23.444753984340778 -10.135048512920998 0.20486241364271404 7.935170726379146e-18 2.5092427895914997 0.9993763630778856 0.012689337014339386 1.690334776752768 0.09675955721291843 1.1287841670357524 0.2087296888380039 7.327426774520457e-11 10.135048512920998 2.5092427895914997 FSVSPVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSVSPVVR 8 0 P13639 P13639 EEF2 Elongation factor 2 0 37884100.0 13602000.0 5960100.0 18322000.0 False True 13170211.955358356 8339999.0115108965 13522918.55178197 1.0 0.6332471367795818 1.0267806317483077 23.650775228065932 -11.801633547105702 17.162227501941246 0.9014265051850469 0.8470124958375502 0.0 0.18386352534046008 0.0 0.0 0.0 0.05341583333028615 1.5789430024620385e-12 11.801633547105702 -0.05441400934749663 FSVSPVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSVSPVVR 8 0 P13639 P13639 EEF2 Elongation factor 2 0 62991000.0 8709000.0 29506000.0 24776000.0 False True 11928952.651875589 28202327.356706027 18924419.07773711 1.0 2.364191407220631 1.5864275456539452 23.50796404586367 -10.069732193058623 5.132261102155213 0.9999840736328399 1.9753094764371881 0.6770714729699878 0.3175207668787871 5.957446510771642e-05 1.0797556976659931e-05 0.30744331629084165 0.10247938684833052 8.51663052860082e-11 10.069732193058623 0.9753254028043482 FSWNVWPSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSWNVWPSSR 10 0 A0A2R8YFH5;Q15437;Q5QPE2;G3V4V1;G3V1W4;G3V3G5;G3V2R6;A0A2R8YF30;G3V5K1;A0A2R8Y633;A0A2R8Y7S7;G3V5X8;G3V4Q2;F5H365;Q15436 A0A2R8YFH5;F5H365 SEC23B;SEC23A Protein transport protein Sec23B;Protein transport protein Sec23A 0 33890800.0 9324800.0 10537000.0 14029000.0 False True 12224903.101491643 8964920.672904309 12577413.655670417 1.0 0.733332656993448 1.0288354477129362 23.54331969417011 -6.66894145636144 1.9407026250879431 0.8296393069766124 1.0276474945848428 0.2745803289938151 0.11330090616969912 0.4635312365196855 3.3646112792584253 0.047012685029445105 0.12579910684365106 2.14317948590687e-07 6.66894145636144 0.19800818760823047 FSWNVWPSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSWNVWPSSR 10 0 A0A2R8YFH5;Q15437;Q5QPE2;G3V4V1;G3V1W4;G3V3G5;G3V2R6;A0A2R8YF30;G3V5K1;A0A2R8Y633;A0A2R8Y7S7;G3V5X8;G3V4Q2;F5H365;Q15436 A0A2R8YFH5;F5H365 SEC23B;SEC23A Protein transport protein Sec23B;Protein transport protein Sec23A 0 26301200.0 10495000.0 3698200.0 12108000.0 False True 10161841.969672564 5174910.545858232 8936551.56778604 1.0 0.5092492641887619 0.8794224112573947 23.27665859778351 -9.762987423294991 6.0754867744558245 1.0000000093280532 0.6943358377223984 0.47619658954353183 0.15112255446882497 1.898328031688643e-08 3.94772295878095e-09 0.1463237885332389 0.048774594724150924 1.7258878711385707e-10 9.762987423294991 -0.30566417160565484 FSWNVWPSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSWNVWPSSR 10 0 A0A2R8YFH5;Q15437;Q5QPE2;G3V4V1;G3V1W4;G3V3G5;G3V2R6;A0A2R8YF30;G3V5K1;A0A2R8Y633;A0A2R8Y7S7;G3V5X8;G3V4Q2;F5H365;Q15436 A0A2R8YFH5;F5H365 SEC23B;SEC23A Protein transport protein Sec23B;Protein transport protein Sec23A 0 31626800.0 9324800.0 10328000.0 11974000.0 False True 12772430.55324484 9871674.8098712 9145987.812270915 1.0 0.7728892921921817 0.7160726201754429 23.606529755693 -13.999999999999995 0.19458424860363333 2.2373540555376232 0.6771398669576097 0.9994875329118562 0.0027768707935448655 12.429032408484389 0.1398868229929724 5.840587508041654 0.03769531960387529 1.0000000000000123e-14 13.999999999999995 -1.5602141885800136 FSWNVWPSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSWNVWPSSR 10 0 A0A2R8YFH5;Q15437;Q5QPE2;G3V4V1;G3V1W4;G3V3G5;G3V2R6;A0A2R8YF30;G3V5K1;A0A2R8Y633;A0A2R8Y7S7;G3V5X8;G3V4Q2;F5H365;Q15436 A0A2R8YFH5;F5H365 SEC23B;SEC23A Protein transport protein Sec23B;Protein transport protein Sec23A 0 24808500.0 10495000.0 5105300.0 9208200.0 False True 8727057.507332236 5077796.735577292 11133592.04609364 1.0 0.5818452246144895 1.2757555495353963 23.057063873217785 -6.743506815648111 1.6737645751232113 0.7522302395788594 1.276494891880321 0.6207321720111472 0.17568218221800141 0.3114504519090196 1.7144698540681669 0.08299114879069072 0.2028814846037463 1.805066408901509e-07 6.743506815648111 0.5242646523014616 FSWSSNLMQHQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSWSSNLMQHQR 12 0 Q6DD87 Q6DD87 ZNF787 Zinc finger protein 787 0 5781600.0 1232600.0 1788500.0 2760500.0 False True 1615950.5365153807 1521662.7715183964 2474869.9405858 1.0 0.9416518248137066 1.5315258014781716 20.623951607874208 -6.882574521163293 1.0652884190092156 0.9624378294302012 1.5754581005238664 0.9757054482632083 0.04136520374547163 0.1253761480761795 0.2586869016918464 0.029837944598030346 0.07265473779697068 1.310465158626576e-07 6.882574521163293 0.6130202710936652 FSYDQK(ub)YHVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSYDQKYHVR 10 1 Q8NB14;Q8NB14-2 Q8NB14 USP38 Ubiquitin carboxyl-terminal hydrolase 38 1 7414850.0 3838500.0 2921100.0 655250.0 True False 5032310.672086872 2485283.2663586186 587451.0156018272 1.0 0.49386522977286396 0.11673584042819328 22.26278955975356 -8.118426444558606 0.38471513766046544 1.0761388397474287 5.0639686907766647e-20 0.9975997952852363 0.017728733445694846 0.09535561713040938 0.09065924904043289 0.05773543124224703 0.08399618726118196 7.613310729512795e-09 8.118426444558606 -1.0761388397474287 FSYDQK(ub)YHVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSYDQKYHVR 10 1 Q8NB14;Q8NB14-2 Q8NB14 USP38 Ubiquitin carboxyl-terminal hydrolase 38 1 6755600.0 2117800.0 2591700.0 2046100.0 True False 2050571.5982251132 3626579.3255369533 1510165.028315745 1.0 1.768569958091668 0.7364605213604242 20.967594687337492 -6.7073203778723505 1.804742264857507 1.4737839563085164 0.7390681149932563 0.45239460223496997 0.3240095757001553 0.38047574267863565 2.413988840424171 0.1429612611673034 0.3643757931915861 1.961912445331739e-07 6.7073203778723505 -0.7347158413152601 FSYDQK(ub)YHVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSYDQKYHVR 10 1 Q8NB14;Q8NB14-2 Q8NB14 USP38 Ubiquitin carboxyl-terminal hydrolase 38 1 6790610.0 3838500.0 2023400.0 928710.0 True False 5257697.181562105 1933999.4975109831 709367.8253828399 1.0 0.36784155319808204 0.13491987097896743 22.325999621276452 -10.18251287520242 0.23869091432224723 1.6374466001608414 6.990720048222091e-22 0.9991577278880611 0.010607195126187102 1.7242124056361607 0.11341803110115554 0.8095206970136064 0.11013356150895762 6.568816421107653e-11 10.18251287520242 -1.6374466001608414 FSYDQK(ub)YHVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSYDQKYHVR 10 1 Q8NB14;Q8NB14-2 Q8NB14 USP38 Ubiquitin carboxyl-terminal hydrolase 38 1 8244370.0 2117800.0 5140100.0 986470.0 True False 1761044.534447662 5112409.261070034 1192736.316078061 1.0 2.9030550682089937 0.6772891274167314 20.747999962771768 -6.680298676109236 1.9006680852557816 2.2037520072269103 0.6857095399514086 0.3255529436851653 0.8065056406230037 0.4378651031926841 3.05848081915793 0.34043995377546105 0.8975961098952321 2.0878597591388692e-07 6.680298676109236 -1.5180424672755017 FSYDQK(ub)YHVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSYDQKYHVR 10 1 Q8NB14;Q8NB14-2 Q8NB14 USP38 Ubiquitin carboxyl-terminal hydrolase 38 1 7723000.0 3638500.0 2109000.0 1975500.0 True False 4710109.975557529 1991632.296040002 1615979.270341735 1.0 0.42284199442800807 0.3430873756085608 22.167329314796877 -13.999999999999998 0.2788523644690061 5.674175189054944 0.31880497853601875 0.9996026406985639 0.005834440354162863 15.336503603357427 0.16726334055624995 40.8536845532809 0.03172166089394075 1.0000000000000041e-14 13.999999999999998 -5.355370210518926 FSYIGLSQNNLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSYIGLSQNNLR 12 0 Q96S59 Q96S59 RANBP9 Ran-binding protein 9 0 6518600.0 1721100.0 2156900.0 2640600.0 False True 2256378.76715611 1835098.9275303518 2367376.042423785 1.0 0.8132938291398966 1.049192660772807 21.105577835478723 -6.695724295734948 1.8458155561759069 0.8835843715021403 1.0484449079899154 0.39749046385392783 0.0788737577842534 0.40446280716111466 2.675890011541122 0.034127225857118894 0.08824228006043748 2.015003033387973e-07 6.695724295734948 0.1648605364877751 FSYK(ub)SITTDDWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FSYKSITTDDWK 12 1 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 1 193788000.0 60181000.0 71880000.0 61727000.0 True False 78897873.79363297 61155784.18604547 55340082.16719419 1.0 0.7751258842032409 0.701414113033552 26.233483086012836 -13.999999999999998 0.15593250028915012 2.098490109275582 0.6255984239574092 0.9995476602222249 0.0027010127239852624 11.985085782632053 0.12463934527459535 3.9837592809364613 0.0687640176763596 1.0000000000000041e-14 13.999999999999998 -1.4728916853181726 FSYK(ub)SITTDDWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FSYKSITTDDWK 12 1 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 1 117407000.0 16275000.0 80366000.0 20766000.0 True False 15758359.033484612 112456562.90315334 15326761.63335359 1.0 7.136311760900784 0.9726115264150328 23.909613974544353 -6.647185015592262 2.0186193136991326 4.990641868546454 0.9984413944190618 0.18277693490779356 2.6208539504881583 0.5153990869535658 4.022251861407865 1.0541524814262027 2.9025496893386173 2.253279078892179e-07 6.647185015592262 -3.992200474127393 FSYK(ub)SITTDDWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FSYKSITTDDWK 12 1 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 1 259047000.0 88717000.0 108047000.0 62283000.0 True False 134590175.08147615 88765168.6749358 49972737.75039136 1.0 0.6595219050811139 0.37129558468989005 27.00399785791359 -7.464380945743236 0.22140120271132965 1.164571774559879 4.2303489560924864e-13 0.9999319392878111 0.0021199075055329556 0.12522600293823716 0.019716682660887587 0.027231376795455467 0.06226071091356004 3.432567247436267e-08 7.464380945743236 -1.164571774559456 down FSYK(ub)SITTDDWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FSYKSITTDDWK 12 1 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 1 195012000.0 60181000.0 13628000.0 121203000.0 True False 82431542.03037363 13025869.898230528 92577347.6541399 1.0 0.158020456458656 1.1230815944220458 26.296693147535727 -6.676133590859779 1.9157579846425141 0.46543250607428976 1.1192955129791007 0.3064941383261929 0.3571561445478973 0.4471510511729303 3.1694814047073305 0.14978542573177664 0.39699729331632266 2.107979626549685e-07 6.676133590859779 0.6538630069048109 FSYK(ub)SITTDDWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FSYKSITTDDWK 12 1 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 1 179738000.0 16275000.0 88783000.0 74680000.0 True False 13533383.60474818 88304708.35695426 90295242.71869358 1.0 6.524954212187749 6.672037485659798 23.69001924997863 -10.06599018081817 0.8040768746751988 1.1128705981553673e-18 6.640675314521953 0.999909126200495 0.025164993063021612 1.3596297703358828 0.42399902580847826 3.4316699887418336 0.021130699786586785 8.590329435926368e-11 10.06599018081817 6.640675314521953 FSYK(ub)SITTDDWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FSYKSITTDDWK 12 1 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 1 192760000.0 88717000.0 59129000.0 44914000.0 True False 114845905.37351581 55838419.17143166 36740112.856557146 1.0 0.4862029603043066 0.3199079038740344 26.77512418000604 -13.999999999999998 0.15777256861815248 3.5188324766379027 0.15234631714820104 0.9995424053520836 0.006192310169069427 11.995570700302677 0.1254438742684113 9.248232474514158 0.15230176131422565 1.0000000000000041e-14 13.999999999999998 -3.3664861594897015 FTASAGIQVVGDDLTVTNPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTASAGIQVVGDDLTVTNPK 20 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 16031200.0 8356300.0 5862400.0 1812500.0 False True 10955190.222524302 4987752.771456221 1624959.8867276802 1.0 0.4552867335156997 0.1483278568168263 23.38511119926627 -8.634090487949857 0.30034261261938083 1.1937105097170042 6.116910210839202e-22 0.9987011840677035 0.012692273247161047 0.23505922140643318 0.08884407255021151 0.14300075610402138 0.09713781145144604 2.3222528901484944e-09 8.634090487949857 -1.1937105097170042 FTASAGIQVVGDDLTVTNPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTASAGIQVVGDDLTVTNPK 20 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 94717000.0 43721000.0 19372000.0 31624000.0 False True 42333100.78666543 27107340.623645443 23340725.70033582 1.0 0.6403343983766014 0.5513587539443354 25.33528283030008 -13.999999999999991 0.19617197830514962 2.970923257457076 0.49134449984921846 0.9994871808638978 0.0043921289632978654 12.457796795065901 0.1404528226825246 9.406529789999972 0.058315780788663334 1.0000000000000205e-14 13.999999999999991 -2.4795787576078574 FTASAGIQVVGDDLTVTNPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTASAGIQVVGDDLTVTNPK 20 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 697200000.0 151100000.0 323830000.0 222270000.0 False True 229229746.88967192 266040006.40466166 178338237.0755982 1.0 1.1605823852028527 0.7779890677165571 27.772219032275437 -6.792669420060799 1.4854955021847818 1.0894372197626179 0.7736058652088271 0.8099215425119083 0.068388987907818 0.2313835051980731 1.0085876174607227 0.036230785309100476 0.08466890617483996 1.6118721067455522e-07 6.792669420060799 -0.31583135455379074 FTASAGIQVVGDDLTVTNPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTASAGIQVVGDDLTVTNPK 20 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 13371300.0 8356300.0 1603400.0 3411600.0 False True 11445849.930516459 1532556.4862652519 2605850.3441075217 1.0 0.1338962589557646 0.2276677013875492 23.44832126078916 -10.375467963936424 5.812758304817608 1.000191931261325 0.18078198017165567 0.9902690180971734 0.0382820310671118 9.524091009562736e-05 1.0232853482339652e-05 0.037074853963347615 0.012355472398492495 4.2124235887179216e-11 10.375467963936424 -0.8194099510896693 FTASAGIQVVGDDLTVTNPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTASAGIQVVGDDLTVTNPK 20 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 76708000.0 43721000.0 17090000.0 15897000.0 False True 36355948.66870626 16997932.77790058 19220989.200576738 1.0 0.46754199519848366 0.528688974003349 25.115688105734357 -10.159647192802241 5.284570849020838 1.0000181844365432 0.4981154846021689 0.9889897923326477 0.024963149564908374 5.348429836116694e-06 8.504951470470806e-07 0.024171340365890408 0.008056821877700335 6.923932210184879e-11 10.159647192802241 -0.5019026998343743 FTASAGIQVVGDDLTVTNPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTASAGIQVVGDDLTVTNPK 20 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 509810000.0 151100000.0 229830000.0 128880000.0 False True 195601928.62628606 217039758.46319285 105425162.42047203 1.0 1.1095992763847722 0.5389781336046827 27.543345354367887 -6.856942294687683 1.201108238641692 1.0590455390426556 0.5129196633066878 0.949809890212891 0.05539020510360209 0.14998757748977076 0.4129215567461092 0.03601022675496793 0.08378907253123564 1.3901373284243913e-07 6.856942294687683 -0.5461258757359678 FTASAGIQVVGDDLTVTNPK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTASAGIQVVGDDLTVTNPKR 21 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 14182500.0 5747200.0 3265700.0 5169600.0 True False 5564758.281858228 4569711.040400516 3815526.6753243064 1.0 0.8211876974599807 0.6856590137550764 22.407887591457776 -6.974193552534977 0.12168237933298434 1.2377046976115085 0.2656555599652496 0.9999994117272357 9.856871809772187e-05 0.0749638115155446 0.0036283644696357654 0.009363053438894486 0.019351164392510972 1.0612224955079004e-07 6.974193552534977 -0.9720491376462589 FTASAGIQVVGDDLTVTNPK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTASAGIQVVGDDLTVTNPKR 21 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 68616200.0 9526200.0 13287000.0 45803000.0 True False 14451941.858506918 10915831.038195165 36750016.97383189 1.0 0.755319329752889 2.542912041415358 23.784760020011188 -6.872319928093844 1.1216866897392488 0.8594572616194649 2.652353166161456 0.966947356394752 0.14386819365630107 0.1346531569900552 0.31522000410745926 0.09938958672871083 0.23631554343948788 1.3417761619229372e-07 6.872319928093844 1.792895904541991 up FTASAGIQVVGDDLTVTNPK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTASAGIQVVGDDLTVTNPKR 21 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 12634600.0 5747200.0 3371800.0 3515600.0 True False 4779051.444129564 3353635.4441501037 4250695.70570218 1.0 0.7017366277296729 0.8894433875416011 22.188292866892052 -10.436990903444322 5.7457837739025095 1.0001190072967898 0.7955900076356368 0.6125812981005248 0.07663096380173144 0.00011689089914220804 1.1453713394815435e-05 0.07424062542674921 0.02473253721732734 3.656024492932136e-11 10.436990903444322 -0.204528999661153 FTASAGIQVVGDDLTVTNPK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTASAGIQVVGDDLTVTNPKR 21 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 71164200.0 9526200.0 12383000.0 49255000.0 True False 12331853.68947537 11693875.164468156 40291095.39897851 1.0 0.948265804876383 3.2672375470497976 23.555886342103637 -6.9018008731979315 0.9498359994421977 0.9082884280541869 3.519733303603173 0.987440173008341 0.12116922311431702 0.11009191670526515 0.17004914310838448 0.09534499326664274 0.25038306830022183 1.253715879940716e-07 6.9018008731979315 2.611444875548986 up FTASAGIQVVGDDLTVTNPKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTASAGIQVVGDDLTVTNPKR 21 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 168535000.0 27747000.0 69321000.0 71467000.0 False True 42094227.5774171 56950125.94255496 57341516.12490108 1.0 1.3529200847744696 1.3622180385527234 25.32711907288537 -11.781347712060683 0.565899139976606 6.905128460124241e-14 1.3612841321364806 0.9999436459525817 0.0012656738564787036 5.850067686311533 0.2806405113779309 7.123537103252439 0.0016966120827391473 1.6544448239714222e-12 11.781347712060683 1.3612841321364115 FTASAGIQVVGDDLTVTNPKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTASAGIQVVGDDLTVTNPKR 21 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 126830000.0 27747000.0 52091000.0 46992000.0 False True 35919038.47513936 49192090.058330916 38439938.17863773 1.0 1.3695269179429241 1.070182828118942 25.09824539497782 -10.111562059601944 5.593763815055265 0.9999976426498655 1.2198548730309724 0.418345243664379 0.12220671293124026 3.592711508316067e-06 5.70853221607571e-07 0.11832741039860627 0.03944204699810022 7.734601453454605e-11 10.111562059601944 0.21985723038110694 FTATASLGVIHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTATASLGVIHK 12 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 18753100.0 3034700.0 4350400.0 11368000.0 False True 3978521.088076606 3701337.2777263788 10191748.409556018 1.0 0.9303299381318021 2.561692695333472 21.923800815317374 -6.89692481584623 0.9805189343456435 0.9263332125930267 2.7226195817381584 0.9849728125281617 0.09232492774974832 0.11370389772374037 0.19046711500573182 0.07100928832130096 0.18205931570836406 1.2678713380983657e-07 6.89692481584623 1.7962863691451316 up FTATASLGVIHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTATASLGVIHK 12 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 20714600.0 3020500.0 1935100.0 15759000.0 False True 2924615.8808381055 2707795.5214131894 11631245.140133819 1.0 0.9258636456002619 3.977016337885938 21.47981572284055 -6.901331610788691 0.9528070495016515 0.877737642769481 4.306094947303787 0.9872173618597174 0.1606785572038105 0.11043185198550153 0.17194153403855858 0.12615444588431268 0.3304819950676748 1.2550712729265152e-07 6.901331610788691 3.4283573045343063 up FTATASLGVIHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTATASLGVIHK 12 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 142785000.0 11284000.0 43453000.0 88048000.0 False True 17118652.97090045 35698472.650161415 70645274.20719068 1.0 2.0853552385718848 4.126801000480513 24.029065847921455 -6.961227652604762 0.41777256727120754 0.9075712665516954 5.381312793233662 0.9998130541016832 0.017723389614592692 0.07926546153109891 0.01953228158488494 0.026372754179698282 0.17004148956860138 1.0933830761073505e-07 6.961227652604762 4.473741526681967 FTATASLGVIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTATASLGVIHK 12 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 22369600.0 3034700.0 3004900.0 16330000.0 False True 4156710.599683872 2872133.5821245187 12473190.32690697 1.0 0.6909630856531007 3.000735804858675 21.987010876840266 -6.873166265950048 1.1171658961263942 0.8213682618098477 3.14443013203028 0.9677445050103028 0.183872580865796 0.13385745402581797 0.31031149909449496 0.1274685619803452 0.3035705087665272 1.3391639017600932e-07 6.873166265950048 2.323061870220432 up FTATASLGVIHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTATASLGVIHK 12 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 11323800.0 3020500.0 1421300.0 6882000.0 False True 2511679.580838205 1413643.1747940392 8320994.381227223 1.0 0.5628278326498455 3.312920344103095 21.260220998274825 -6.866222611306515 1.1539772594654711 0.7576147269029476 3.462769536884379 0.9607608717619397 0.23902089546115188 0.1405234466963403 0.3521328517991877 0.16109720920898107 0.37907265179330446 1.3607470099635125e-07 6.866222611306515 2.7051548099814315 up FTATASLGVIHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTATASLGVIHK 12 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 171631000.0 11284000.0 102943000.0 57404000.0 False True 14607360.440893527 97214131.55583021 46957061.01477948 1.0 6.6551470369470564 3.214616439758854 23.800192170013904 -9.416291977670655 9.735319828786917 1.0000738673082816 4.934881738352963 0.6355710598003406 1.4045907352381692 0.0 0.0 1.3599891514250269 0.4533297103870353 3.834493644911296e-10 9.416291977670655 3.934807871044681 FTDEEVDELYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTDEEVDELYR 11 0 J3QRS3;P19105;O14950 J3QRS3 MYL12A;MYL12B Myosin regulatory light chain 12A;Myosin regulatory light chain 12B 0 18444700.0 6219500.0 1961200.0 10264000.0 False True 6022065.376882183 2744317.3875228935 7575550.486600259 1.0 0.45571032789811966 1.257965500620713 22.521826939690275 -6.724004541354676 1.744832377033641 0.6702768462507672 1.2570088246788715 0.5313022220779569 0.22893534012291428 0.34763237792971646 2.0703976286194905 0.1040936900696373 0.260098641159131 1.8879716067466449e-07 6.724004541354676 0.5867319784281043 FTDINDSLGK(ub)LDFSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTDINDSLGKLDFSR 15 1 Q9NZC7-2;Q9NZC7;A0A087WZG5 Q9NZC7-2 WWOX WW domain-containing oxidoreductase 1 3704500.0 1317400.0 1252000.0 1135100.0 True False 1804478.3813963586 1196682.5001896564 867012.758118317 1.0 0.6631736420491933 0.4804783293925622 20.78315042841463 -11.892494635405695 0.09397981813460098 2.21257749898256 1.0003640876128852e-09 0.999885668134404 0.002300856985168686 5.362183669802006 0.06782838757066799 1.662519721253109 0.35097377858056505 1.280870916313138e-12 11.892494635405695 -2.212577497982196 FTDLLQLVEFHQLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTDLLQLVEFHQLNR 15 0 Q14451-4;Q14451;Q14451-3 Q14451-4 GRB7 Growth factor receptor-bound protein 7 0 5709100.0 2583100.0 1998700.0 1127300.0 False True 2501100.904417452 2796791.3330828035 832026.3117249092 1.0 1.1182241100881225 0.3326640321689468 21.25413183210739 -6.868563340892879 1.1415933208200262 1.066323374158388 0.2878820030734724 0.963232147823209 0.06631374049872776 0.1382438194048016 0.33761064667196117 0.04511766167723424 0.10656541574176871 1.3534326811027346e-07 6.868563340892879 -0.7784413710849156 down FTDLLQLVEFHQLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTDLLQLVEFHQLNR 15 0 Q14451-4;Q14451;Q14451-3 Q14451-4 GRB7 Growth factor receptor-bound protein 7 0 3845700.0 674600.0 1681300.0 1489800.0 False True 924017.8503795231 1607014.6066843981 1137939.9233941217 1.0 1.7391596991598668 1.231512922533622 19.817561196646615 -10.620435384273694 5.619071924607313 0.9964252810190928 1.4853363108467434 0.5492880282227433 0.20724592871715528 0.009329327716729084 0.0006301891086315127 0.20171013511127772 0.06688833587423594 2.3964292716578477e-11 10.620435384273694 0.48891102982765067 FTDLLQLVEFHQLNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTDLLQLVEFHQLNR 15 0 Q14451-4;Q14451;Q14451-3 Q14451-4 GRB7 Growth factor receptor-bound protein 7 0 4802870.0 2583100.0 844770.0 1375000.0 False True 2147962.1007327163 840219.0563362832 1662506.1427183112 1.0 0.3911703358498115 0.7739923074765586 21.034537107541667 -10.142744814683882 5.34324006597225 1.0000109660854508 0.5825813216630763 0.6131853093908084 0.15628641546923075 2.0416831152706077e-05 3.2758102834522857e-06 0.1513276437144689 0.05044122369581114 7.19871840304227e-11 10.142744814683882 -0.4174296444223745 FTEEIPLK(ub)ILAHNNFVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTEEIPLKILAHNNFVGR 18 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 22243500.0 9004800.0 7324800.0 5913900.0 True False 8718947.552978314 10249630.83832739 4364872.176802936 1.0 1.1755582627430998 0.5006191573330355 23.05572256995316 -6.837621482689754 1.293372070108386 1.0934408089433496 0.4794413397922664 0.9202934460304479 0.08072152157393198 0.1715925942383505 0.5586035901556716 0.04895714312349807 0.11272759392414831 1.4533777837599521e-07 6.837621482689754 -0.6139994691510833 FTEEIPLK(ub)ILAHNNFVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTEEIPLKILAHNNFVGR 18 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 13221700.0 2949400.0 4850600.0 5421700.0 True False 4039872.884538047 4636284.453210813 4141206.123416509 1.0 1.147631271012371 1.0250832740966427 21.94587846830824 -10.217739487771926 3.8672122844473833 0.9999190113975907 1.0863572725823363 0.3983517809327679 0.05003001033504507 35231181.10553014 3.7353696518259643 25566.3943683931 0.017126603244351044 6.057040983590132e-11 10.217739487771926 0.08643826118474562 FTEEIPLK(ub)ILAHNNFVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTEEIPLKILAHNNFVGR 18 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 21004300.0 9004800.0 6019100.0 5980400.0 True False 7487890.180278725 5986673.913602196 7230873.989754607 1.0 0.7995141180581993 0.9656757532046829 22.836127845387438 -10.052138860176646 5.7542695718780035 1.000000412513617 0.8825949356692697 0.3996365081832053 0.06783520348930655 3.5898689792081183e-07 5.9020543808438115e-08 0.06568138432808929 0.02189371778337877 8.868724004484765e-11 10.052138860176646 -0.11740547684434732 FTELQK(ub)AVGPEITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTELQKAVGPEITK 14 1 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 30916100.0 6425100.0 12787000.0 11704000.0 True False 6221138.717421935 17892915.783324078 8638371.287526246 1.0 2.8761480166349633 1.3885514662026412 22.56874724479538 -6.588098484915174 2.2359440544567453 2.2712964394199746 1.3927380816624741 0.0 0.8133847358303963 0.6751223888620455 6.360214087027805 0.3040057505546833 0.9071297862609786 2.5816746781464925e-07 6.588098484915174 -0.8785583577575005 FTELQK(ub)AVGPEITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTELQKAVGPEITK 14 1 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 36679100.0 6425100.0 17306000.0 12948000.0 True False 5342755.330191554 17212769.143027972 15655366.935212161 1.0 3.221702675726093 2.930204729148784 22.349152520229655 -10.08244831353029 5.435121747135871 0.999978610644098 3.075953702438597 0.9854279116470156 0.1190035383679847 3.0845664838626935e-05 5.20685137083586e-06 0.11522586022953511 0.038408226852657136 8.270879365093701e-11 10.08244831353029 2.075975091794499 FTEWLHEVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTEWLHEVLK 10 0 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 0 3346500.0 0.0 1241900.0 2104600.0 False True 0.0 1056613.3608882846 1886836.1807487323 0.0 FTEWLHEVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTEWLHEVLK 10 0 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 0 2617400.0 0.0 1071200.0 1546200.0 False True 0.0 1498935.746234203 1141203.834994285 0.0 FTEWLHEVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTEWLHEVLK 10 0 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 0 4315800.0 0.0 2122900.0 2192900.0 False True 0.0 2029103.258508481 1674982.18419316 0.0 FTEYETQVK(ub)VMSQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTEYETQVKVMSQR 14 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 15982700.0 4650700.0 6989700.0 4342300.0 True False 6097112.737442863 5946864.0056372 3893000.4502828196 1.0 0.9753573964799808 0.6384990105850575 22.53969479142911 -6.921601438025441 0.8127711724313085 1.0070123829150197 0.5821268081268818 0.9946140859298764 0.012102692405405877 0.09723875212489698 0.10080198479864184 0.010517095237714814 0.03200208744947704 1.1978393115625764e-07 6.921601438025441 -0.42488557478813793 FTEYETQVK(ub)VMSQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTEYETQVKVMSQR 14 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 20092200.0 4279900.0 4516300.0 11296000.0 True False 4144036.9171988117 6319682.142193361 8337238.727263883 1.0 1.5250062363018693 2.0118640093823035 21.982605424670652 -6.97203152631098 0.20390779678685383 0.7244283253406459 2.82594142301317 0.9999941926072227 0.00099570957091027 0.07564886090809278 0.0066158876614341765 0.0153098504639189 0.05118624915101737 1.0665186976802133e-07 6.97203152631098 2.101513097672524 FTEYETQVK(ub)VMSQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTEYETQVKVMSQR 14 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 63919900.0 8410900.0 16957000.0 38552000.0 True False 12759950.219155148 13930890.864354292 30932180.302058168 1.0 1.0917668662563695 2.424161518719955 23.605119364888136 -6.920828307330461 0.8185667346840311 0.9714703594287759 2.6431650151846755 0.9944078177452921 0.048667833430643015 0.09768673151422563 0.10310884378296957 0.04211730053058068 0.12717653647004365 1.1999736033311696e-07 6.920828307330461 1.6716946557558996 up FTEYETQVK(ub)VMSQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTEYETQVKVMSQR 14 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 14014400.0 4650700.0 4273800.0 5089900.0 True False 6370189.470441813 4084969.384433341 3887770.449781002 1.0 0.6412634040773708 0.6103068782836942 22.602904852952 -13.999999999999998 0.3469400895895027 5.329306386081313 0.6058551335760194 0.999748835421153 0.0028028811966526275 20.359396920236073 0.18940020942237315 64.86333766763327 0.00933412047500501 1.0000000000000041e-14 13.999999999999998 -4.723451252505293 FTEYETQVK(ub)VMSQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTEYETQVKVMSQR 14 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 15023300.0 4279900.0 5420600.0 5322800.0 True False 3558926.4817180717 5391398.151895145 6435772.870153472 1.0 1.5148944996729596 1.8083466751037247 21.763010700104928 -9.789197761293057 0.12409295727512937 1.3668823003247403e-18 2.4151801019679358 0.999865812585147 0.0038702819329064827 1.3170104368145836 0.054667499374265065 0.754289909025615 0.321951898377163 1.6248087107911792e-10 9.789197761293057 2.4151801019679358 FTEYETQVK(ub)VMSQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTEYETQVKVMSQR 14 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 90463900.0 8410900.0 13838000.0 68215000.0 True False 10888075.853625616 13067903.135420375 55800569.94500701 1.0 1.2002031682272767 5.124924798023518 23.376245686980585 -6.917483483788969 0.8431709973998056 0.9053030511291152 5.722602207072579 0.9934530521312477 0.1536606202028701 0.09967532358908805 0.11345075221024228 0.13065954096669458 0.3824530768014999 1.2092511698681552e-07 6.917483483788969 4.817299155943464 up FTFGLDWVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTFGLDWVPK 10 0 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 0 16684700.0 4177600.0 7601700.0 4905400.0 False True 5476874.055935946 6467555.991194514 4397836.26391943 1.0 1.1808845566176287 0.8029829094121612 22.38492127441844 -6.7765903361899085 1.5495798819501414 1.1028772464487975 0.8003255594649935 0.7549851611868739 0.07638907009955485 0.25591414287085984 1.2135636342924512 0.03884020908858035 0.09189509441586931 1.6726676740201117e-07 6.7765903361899085 -0.30255168698380397 FTFGLDWVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTFGLDWVPK 10 0 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 0 30163200.0 11194000.0 9033200.0 9936000.0 False True 10838652.597285824 12640203.867515676 7333463.526389338 1.0 1.1662154270615694 0.6766028766551442 23.369682083999646 -6.815135112519263 1.3930798156367097 1.0900518381891022 0.6670138411709722 0.8727531555876539 0.07251619862658609 0.19988530402513613 0.7635395917857091 0.04092157435884225 0.09444856894004149 1.530611202100584e-07 6.815135112519263 -0.42303799701813005 FTFGLDWVPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTFGLDWVPK 10 0 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 0 39252000.0 11362000.0 14400000.0 13490000.0 False True 17236984.673464276 11830207.492286477 10823695.587122958 1.0 0.6863269717062904 0.6279343975855389 24.039004084977574 -13.999999999999998 0.23641715035462585 3.0407556699310336 0.6012230796455228 0.9995191965157602 0.0035824370237403694 13.499669588132674 0.15391184629931842 12.979415756847992 0.02914613877933758 1.0000000000000041e-14 13.999999999999998 -2.439532590285511 FTFGLDWVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTFGLDWVPK 10 0 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 0 25172600.0 4177600.0 10552000.0 10443000.0 False True 5722171.615395041 10085777.749202276 7976578.480336154 1.0 1.762578689892366 1.3939774995345846 22.44813133594133 -10.228087930660632 4.669796979235415 0.9998562976159364 1.5782780947161907 0.7664478546725599 0.15048080583580858 106076051.7904916 41.86397661599436 163906.29265911743 0.051513582390997445 5.914418741002354e-11 10.228087930660632 0.5784217971002543 FTFGLDWVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTFGLDWVPK 10 0 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 0 24314100.0 11194000.0 5172600.0 7947500.0 False True 9308306.978282712 5144734.177119286 9609285.504911844 1.0 0.5527035355755356 1.032334400587706 23.150087359433922 -11.846667570348883 17.63129956052113 0.9017921609917685 0.8132670712734588 0.0 0.22416737614192897 0.0 0.0 0.0 0.06511674733387544 1.4234179220058465e-12 11.846667570348883 -0.08852508971830975 FTFGLDWVPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTFGLDWVPK 10 0 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 0 31412900.0 11362000.0 12052000.0 7998900.0 False True 14708332.978503387 11381295.605440557 6543182.275644901 1.0 0.773799153314969 0.44486226176738947 23.810130407070023 -6.965767649433994 0.3446233698410708 1.0338201925592818 0.17383264676660684 0.9999281056507763 0.001932571307812568 0.0777014180481895 0.013946788713732236 0.004580734617502717 0.028376804250783438 1.0820126807757943e-07 6.965767649433994 -0.859987545792675 down FTFGLDWVPK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTFGLDWVPKK 11 1 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 1 20829400.0 5529700.0 6892000.0 8407700.0 True False 8388959.175220517 5662068.752558228 6745914.4097741805 1.0 0.6749429380086822 0.8041420000827282 23.000060394781187 -10.186824730164444 4.865668594122106 1.0000287802883958 0.7395424690450002 0.8442048315144391 0.052745296223697904 1.646917989101693e-05 2.7524524556153533e-06 0.051076051760661705 0.017023471155083184 6.503921185455952e-11 10.186824730164444 -0.2604863112433956 FTFGLDWVPKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTFGLDWVPKK 11 1 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 1 11436700.0 3520500.0 2894800.0 5021400.0 True False 3408743.654524273 4050708.736182576 3706144.701229009 1.0 1.1883289407246131 1.087246527414876 21.70080867884832 -10.356971969897705 5.769806546282373 0.9999731431107127 1.1377877340697364 0.7124347262446847 0.041266722429663304 1.4259680172234313e-05 1.5892543553811833e-06 0.03996411581268005 0.013318777393553964 4.395699851145191e-11 10.356971969897705 0.1378145909590237 FTFGLDWVPKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTFGLDWVPKK 11 1 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 1 19001500.0 9172000.0 0.0 9829500.0 True False 13914594.563018354 0.0 7886695.016577096 1.0 0.0 0.5667930158409383 23.73009553691668 -9.95589150381711 6.084955978778286 1.000000317632318 0.2833965079203666 0.6806453293455017 0.2313922797642873 9.96941692632404e-07 1.711796588975395e-07 0.22404471164304676 0.07468153716395057 1.1069002771408592e-10 9.95589150381711 -0.7166038097119514 FTFIEK(ub)CNNPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTFIEKCNNPR 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 13537300.0 4393300.0 4939900.0 4204100.0 True False 5759658.844777721 4202886.175579387 3769100.0605748063 1.0 0.7297109583825683 0.6543964082164774 22.457551930032817 -13.999999999999998 0.17927013990797772 2.399290909394013 0.5941171899143196 0.9994990351474506 0.0033212455884528693 12.195394360432124 0.13421507246686265 5.943091251540791 0.05658334085382052 1.0000000000000041e-14 13.999999999999998 -1.8051737194796935 FTFIEK(ub)CNNPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTFIEKCNNPR 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 79667900.0 11709300.0 13535000.0 54423600.0 True False 17763864.164495263 11119573.50056233 43666751.60528869 1.0 0.6259659158386882 2.458178648571614 24.082442108769353 -6.853524444701772 1.217935587397631 0.7996276195792162 2.5365697084114367 0.9452835039039282 0.18489674340550818 0.15362076325191065 0.4367375846370172 0.11867509739970383 0.27531753303113465 1.4011207192314375e-07 6.853524444701772 1.7369420888322205 up FTFIEK(ub)CNNPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTFIEKCNNPR 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 18992000.0 4393300.0 6613400.0 7985300.0 True False 6017621.734468367 6321198.120410751 6099336.602415815 1.0 1.0504479010708712 1.013579262963538 22.52076199155571 -10.163025842666327 3.9095561292525525 0.9999829015602874 1.0320135820220184 0.5013199636919232 0.01505155852476105 1357117.478101128 3533858.711308485 92.48740431606757 0.005152548718581303 6.870275572655117e-11 10.163025842666327 0.032030680461731076 FTFIEK(ub)CNNPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTFIEKCNNPR 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 88023000.0 11709300.0 14804000.0 61509700.0 True False 15157919.674809866 13980144.386238141 50315565.742818944 1.0 0.9222996747681012 3.3194242232616977 23.853568430861802 -6.899406563892471 0.9649904534504007 0.8987069919971301 3.568051054510976 0.9862693709707965 0.13031968382058232 0.11184416607061118 0.17988436696635365 0.10139653241542236 0.26304589398760364 1.260646830063915e-07 6.899406563892471 2.669344062513846 up FTFPDPPPLSPPVLGLHGVTFGYQGQKPLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTFPDPPPLSPPVLGLHGVTFGYQGQKPLFK 31 1 Q8NE71-2;Q8NE71;H0YGW7 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 160896000.0 44401000.0 47397000.0 69098000.0 False True 67359563.14790416 38938635.03554873 55440750.01327078 1.0 0.578071371247607 0.8230568522473528 26.005379446226357 -10.221585598238141 5.5545578968996505 1.0000142087537691 0.7005641117474641 0.665763313514276 0.10001490380666932 1.759925984470438e-05 2.4661524032582307e-06 0.09684360710656108 0.0322796714013058 6.003636672314404e-11 10.221585598238141 -0.299450097006305 FTFPDPPPLSPPVLGLHGVTFGYQGQKPLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTFPDPPPLSPPVLGLHGVTFGYQGQKPLFK 31 1 Q8NE71-2;Q8NE71;H0YGW7 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 152743000.0 114200000.0 21846000.0 16697000.0 False True 94962359.91780277 21728311.261908494 20188265.501794677 1.0 0.2288097229335499 0.2125922894004443 26.500852452175835 FTFPDPPPLSPPVLGLHGVTFGYQGQKPLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTFPDPPPLSPPVLGLHGVTFGYQGQKPLFK 31 1 Q8NE71-2;Q8NE71;H0YGW7 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 116886000.0 44401000.0 28669000.0 43816000.0 False True 57477969.77455806 27073544.94792357 35841937.59012575 1.0 0.4710247257186066 0.6235769588018879 25.776505768318806 -10.691578001216008 10.215941456439866 1.0003198811163763 0.547300842260277 0.9215158694718913 0.06227918836269436 0.0004540401746273228 1.3707584578895678e-05 0.06034075708852944 0.020100521612002493 2.034332787841567e-11 10.691578001216008 -0.4530190388560993 FTFQVIIDGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTFQVIIDGR 10 0 P19525-2;P19525;C9JZT2;F8WBH4 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 0 39090000.0 10438000.0 14022000.0 14630000.0 False True 15835209.120015863 11519664.54561395 11738374.08744322 1.0 0.7274715766811679 0.7412831746317639 23.916632583956403 -10.125117003854905 7.59774936966961 1.0000000598581529 0.7343773756592628 0.9979763300227276 0.005638561251904988 5.720766123446338e-09 6.638668366523846e-10 0.00545951467659009 0.0018198378187665345 7.496922065467064e-11 10.125117003854905 -0.2656226841988901 FTFQVIIDGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTFQVIIDGR 10 0 P19525-2;P19525;C9JZT2;F8WBH4 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 0 30648100.0 10438000.0 8297100.0 11913000.0 False True 13512196.763740405 7835359.091262936 9744956.237702379 1.0 0.5798730752862405 0.7211970346563256 23.687758906048852 -10.397494308678954 5.123825322304574 1.0002859365678713 0.6505350549712617 0.8907455162745722 0.05769526481449584 0.0001886062472217631 2.217809242281417e-05 0.055908264839503265 0.01862106664845344 4.004107155788893e-11 10.397494308678954 -0.3497508815966096 FTFYDGPPFATGLPHYGHILAGTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTFYDGPPFATGLPHYGHILAGTIK 25 0 A0A0A0MSX9;P41252;Q5TCD1 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 86470100.0 36900200.0 21220500.0 28349400.0 False True 35728823.34914828 29693956.31344562 20923841.67623007 1.0 0.8310924774452019 0.5856291843635221 25.090585066903238 -6.965778191799452 0.34443551402704026 1.0252925290547932 0.38321653495093216 0.9999282984847548 0.0014405585390035983 0.07769786577264876 0.013934337203893756 0.003420106583919964 0.02117847043953751 1.0819864155683443e-07 6.965778191799452 -0.642075994103861 FTFYDGPPFATGLPHYGHILAGTIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTFYDGPPFATGLPHYGHILAGTIK 25 0 A0A0A0MSX9;P41252;Q5TCD1 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 50641000.0 15764000.0 14285000.0 20592000.0 False True 23915140.502771623 11735730.140785579 16521982.17420577 1.0 0.4907238633795807 0.6908586705685869 24.51142093147372 -10.16979343846733 5.349051383984266 1.0000148295282802 0.5907912669739662 0.8478904514831123 0.0817046928976402 1.4450000045912134e-05 2.242769008709954e-06 0.07911309301394566 0.026370076241569586 6.764046141829334e-11 10.16979343846733 -0.409223562554314 FTFYDGPPFATGLPHYGHILAGTIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTFYDGPPFATGLPHYGHILAGTIK 25 0 A0A0A0MSX9;P41252;Q5TCD1 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 75415200.0 36900200.0 14366000.0 24149000.0 False True 30684151.256032456 14288607.506572263 29198444.24763968 1.0 0.46566735339512266 0.9515806386171203 24.870990342337514 -10.46590036737039 8.953544656708878 1.0000048124792627 0.7086239960061218 0.32406578798236063 0.19837326800556 1.905695361522145e-05 1.1370828217928755e-06 0.19207726020881394 0.06402469694318957 3.4205790590930337e-11 10.46590036737039 -0.29138081647314085 FTGLSK(ub)EELLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTGLSKEELLK 11 1 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5H0E2;H0YFS2;F5H867;F5GZR9 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 1 19530700.0 7416400.0 8000800.0 4113500.0 True False 9722972.220519774 6807111.826874133 3687874.479478238 1.0 0.7001060655617338 0.37929497234345594 23.212965968786488 -7.043489390877642 0.2604848359436682 1.0931620982910015 2.5272878449249624e-12 0.9999822691318344 0.0010672114275928192 0.0725630520707947 0.009250770667672192 0.007025705282578862 0.029367458212029584 9.047125381542706e-08 7.043489390877642 -1.0931620982884742 down FTGLSK(ub)EELLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTGLSKEELLK 11 1 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5H0E2;H0YFS2;F5H867;F5GZR9 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 1 19315200.0 6777600.0 7024700.0 5512900.0 True False 6562448.797870677 9829699.34332656 4068906.106545073 1.0 1.4978706342845691 0.6200286252694748 22.645802830708966 -6.752852062210981 1.6393971444679445 1.2917431112181255 0.6179069724611327 0.6611398852409454 0.20924384371266222 0.2950805350463113 1.5612064599676105 0.10079256868582094 0.24395857647748936 1.7666395051302708e-07 6.752852062210981 -0.6738361387569928 FTGLSK(ub)EELLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTGLSKEELLK 11 1 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5H0E2;H0YFS2;F5H867;F5GZR9 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 1 63641000.0 15559000.0 13397000.0 34685000.0 True False 23604140.51526413 11006200.678761251 27829494.547024418 1.0 0.46628262832293565 1.179009018736686 24.492536616039647 -6.706301914033003 1.8084982542433152 0.6706440431798076 1.1771495080290972 0.4474443105393626 0.225040905745974 0.38257267438699205 2.4367768587528253 0.09911459825773819 0.2529228203709863 1.966518724509764e-07 6.706301914033003 0.5065054648492896 FTGLSK(ub)EELLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTGLSKEELLK 11 1 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5H0E2;H0YFS2;F5H867;F5GZR9 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 1 15952700.0 7416400.0 4003000.0 4533300.0 True False 10158443.500674032 3826134.2238491895 3462627.9062441792 1.0 0.37664571581220274 0.34086205293305294 23.27617603030938 -13.775698583126644 0.40860729606741136 9.999999906041932 0.3391482103344049 0.9998459894235174 0.003755777090300506 23.16656993185767 0.21139806252171559 184.1577230031803 0.008947777104764857 1.6761057535230744e-14 13.775698583126644 -9.660851695707526 FTGLSK(ub)EELLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTGLSKEELLK 11 1 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5H0E2;H0YFS2;F5H867;F5GZR9 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 1 17631400.0 6777600.0 7563100.0 3290700.0 True False 5635874.698589322 7522356.079142187 3978770.155522291 1.0 1.3347273460542082 0.705972075021148 22.426208106143243 -6.762078849613622 1.6046489304557987 1.193924423541106 0.703435927359181 0.699402555255594 0.14083212288520686 0.2794351104932162 1.418548264317262 0.06923226336610062 0.16603606569054716 1.729502325820335e-07 6.762078849613622 -0.4904884961819249 FTGLSK(ub)EELLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTGLSKEELLK 11 1 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5H0E2;H0YFS2;F5H867;F5GZR9 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 1 52063000.0 15559000.0 13483000.0 23021000.0 True False 20141432.21374182 12732659.19749044 18831414.21540728 1.0 0.6321625524129002 0.9349590443999926 24.263662938132097 -9.980618727705261 6.67385083306451 1.000000034051588 0.7835607984064449 0.40520578622718584 0.12361615021219059 6.263421692657665e-08 9.620709449998703e-09 0.11969084060881101 0.039896940924506616 1.045637794251849e-10 9.980618727705261 -0.2164392356451431 FTIPLSGYGGTSNLILEGVKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTIPLSGYGGTSNLILEGVKK 21 1 A0A0A0MR42;K7ENP4;Q8TEP8-1;Q8TEP8;H0Y966;K7EPA2;Q8TEP8-2;C9JT09 A0A0A0MR42 CEP192 Centrosomal protein of 192 kDa 1 10518300.0 1711400.0 3856500.0 4950400.0 True False 1657072.5437729992 5396420.561381821 3653741.73118335 1.0 3.256598862651285 2.204937704697057 20.660205331962377 -10.66539383960215 7.159930010528383 0.9930420350737693 2.7307682836741702 0.7831419441303629 0.42933886988206027 0.047254821082104916 0.0022083635097195865 0.4119446331551408 0.13856852441106104 2.1607581531851436e-11 10.66539383960215 1.737726248600401 FTIPLSGYGGTSNLILEGVKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTIPLSGYGGTSNLILEGVKK 21 1 A0A0A0MR42;K7ENP4;Q8TEP8-1;Q8TEP8;H0Y966;K7EPA2;Q8TEP8-2;C9JT09 A0A0A0MR42 CEP192 Centrosomal protein of 192 kDa 1 7620700.0 1711400.0 2933200.0 2976100.0 True False 1423104.927875025 2917398.2694053864 3598388.7500683437 1.0 2.0500233062657123 2.5285477406373995 20.440610607396653 -9.658720908008553 0.21174312914837387 3.4840204926774334e-23 2.9326649266701055 0.9993712954193015 0.016007232944287086 1.0946372384449483 0.08858677738353782 0.9425638007298622 0.260873934609402 2.1942145571803033e-10 9.658720908008553 2.9326649266701055 FTIQLQLSQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTIQLQLSQK 10 0 E5RFU8;H0Y2V6;Q5SW79-2;Q5SW79-3;Q5SW79 E5RFU8 CEP170 Centrosomal protein of 170 kDa 0 31856400.0 12466000.0 10178000.0 9212400.0 False True 18911833.386675365 8361656.378923045 7391565.102061645 1.0 0.44213885602515846 0.39084339159150433 24.172785894746767 -13.999999999999998 0.33768114836334123 7.361751328872406 0.3825560347708241 0.9997305546193779 0.004528258056255712 19.493164430378968 0.186261505156941 88.41920267020635 0.015980855714283596 1.0000000000000041e-14 13.999999999999998 -6.979195294101581 FTIQLQLSQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTIQLQLSQK 10 0 E5RFU8;H0Y2V6;Q5SW79-2;Q5SW79-3;Q5SW79 E5RFU8 CEP170 Centrosomal protein of 170 kDa 0 31779700.0 12466000.0 12690000.0 6623700.0 False True 16137482.741596824 11983790.344593486 5418254.564901305 1.0 0.7426059278566066 0.33575587045772187 23.943912216839216 -6.964372240023404 0.36866739465314663 1.0317635701119197 0.03246598538447137 0.9998996140992163 0.0027398155852385118 0.07817462986323251 0.015615007757495374 0.0053737003705179405 0.034578434999814237 1.0854948316023433e-07 6.964372240023404 -0.9992975847274483 down FTITPPTAQVVGVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTITPPTAQVVGVLK 15 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 38856500.0 8453500.0 13550000.0 16853000.0 False True 11082620.363810446 11528392.817486329 15109213.225391231 1.0 1.0402226584546308 1.3633249835688097 23.401795695321027 -6.930018443573019 0.7466315057533465 0.9950902472829707 1.4296894871815733 0.9965421001808117 0.009562903812470698 0.09262781385009529 0.07763045978052029 0.008713295210290444 0.029232105161684438 1.1748476605714715e-07 6.930018443573019 0.4345992398986026 FTITPPTAQVVGVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTITPPTAQVVGVLK 15 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 54714000.0 28518000.0 10153000.0 16043000.0 False True 27612711.699963946 14207145.847195534 11840857.02031645 1.0 0.5145146916959294 0.42881905801131115 24.71882923862748 -13.999999999999998 0.24396034273230535 4.276227312747785 0.39232692279855247 0.9995317131089062 0.005442523152043153 13.766628463911875 0.15631086550548068 22.02377966917435 0.0409215992592032 1.0000000000000041e-14 13.999999999999998 -3.883900389949232 FTITPPTAQVVGVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTITPPTAQVVGVLK 15 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 101615000.0 19656000.0 65516000.0 16443000.0 False True 29819589.046084654 53824157.921155654 13193033.842777077 1.0 1.8049932827032982 0.44242842590445886 24.82975703969805 -6.746613756248993 1.6622694127611088 1.4752593261521707 0.4403851605596862 0.6343254304991937 0.33822257949019197 0.30598414506641586 1.6623635702535087 0.16080383504075346 0.39180277448039524 1.792199054010495e-07 6.746613756248993 -1.0348741655924845 FTITPPTAQVVGVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTITPPTAQVVGVLK 15 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 42358500.0 8453500.0 12647000.0 21258000.0 False True 11578987.397247696 12088213.721963728 16237298.222252827 1.0 1.043978485099403 1.4023072713692049 23.46500575684392 -6.929755497861443 0.7487873837426556 0.9945015257333996 1.4754166400667048 0.996490207195512 0.010674516347154004 0.09276451861407005 0.07830079986055276 0.009710977097146944 0.032466136562011895 1.17555919319453e-07 6.929755497861443 0.48091511433330525 FTITPPTAQVVGVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTITPPTAQVVGVLK 15 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 48114700.0 28518000.0 8630700.0 10966000.0 False True 23713980.561610308 8584204.706040183 13258939.89894473 1.0 0.36198919383179545 0.5591191181293764 24.499234514061758 -10.195683416060488 5.724819678557104 1.0000134085076477 0.4605541559805944 0.9089632019016107 0.08047795459381744 1.3773133058137715e-05 1.9350438913570436e-06 0.07792437878505619 0.025974148156548995 6.372598895332842e-11 10.195683416060488 -0.5394592525270534 FTITPPTAQVVGVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTITPPTAQVVGVLK 15 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 68001000.0 19656000.0 29127000.0 19218000.0 False True 25445079.4776855 27506056.845309228 15720521.193332031 1.0 1.0809970890219123 0.6178216580977243 24.600883361790498 -6.861764590427319 1.1766850319411153 1.0441732847433502 0.5946136656004909 0.9557556866813792 0.04248450804177301 0.14500081278856727 0.3804808561477393 0.028138033407080165 0.06582311772124409 1.374786977148304e-07 6.861764590427319 -0.44955961914285936 FTITPSTTQVVGILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTITPSTTQVVGILK 15 0 P47755 P47755 CAPZA2 F-actin-capping protein subunit alpha-2 0 27732400.0 5456500.0 12505000.0 9770900.0 False True 7153524.340821157 10639302.744108234 8759900.99709103 1.0 1.4872812668569102 1.2245573761597737 22.770222761748347 -10.115027319308986 4.402769822320998 0.9999594382713793 1.3559193215267482 0.7098968145600697 0.10725657934521696 74770931.015399 3.3616785421142237 34252.29144532342 0.03671677995181799 7.6731321997974e-11 10.115027319308986 0.35595988325536887 FTITPSTTQVVGILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTITPSTTQVVGILK 15 0 P47755 P47755 CAPZA2 F-actin-capping protein subunit alpha-2 0 34147000.0 13706000.0 5780000.0 14661000.0 False True 13270910.532285104 8087984.142301811 10820844.279427752 1.0 0.6094520886585428 0.8153806969840616 23.66176402326529 -10.02444305882424 4.931805197781309 1.0000044412716091 0.7124163928177822 0.7222500628280292 0.08407000231867233 4.105425972767277e-06 8.121408832217832e-07 0.0814016861460025 0.027133476572914664 9.452723207686537e-11 10.02444305882424 -0.2875880484538269 FTITPSTTQVVGILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTITPSTTQVVGILK 15 0 P47755 P47755 CAPZA2 F-actin-capping protein subunit alpha-2 0 33558300.0 3518400.0 24929000.0 5110900.0 False True 5337670.0294945175 20480225.17883402 4100728.3748129564 1.0 3.836922302365236 0.7682618730932117 22.34777869130349 -6.66378189904711 1.959211540745917 2.8204169672039425 0.7809131475884589 0.25177364233574384 1.2068236126187872 0.47563354420104276 3.513460971071654 0.49694258415012615 1.3386647492741395 2.1687929905507354e-07 6.66378189904711 -2.0395038196154838 FTITPSTTQVVGILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTITPSTTQVVGILK 15 0 P47755 P47755 CAPZA2 F-actin-capping protein subunit alpha-2 0 34906500.0 5456500.0 13139000.0 16311000.0 False True 7473915.506368014 12558475.535137294 12458677.735589704 1.0 1.6803074003762917 1.6669545869196023 22.833432823271238 -10.090775327169002 4.780630625343436 0.9999696789234573 1.6736309936560207 0.9997053983096972 0.005451263294382546 694933.7454194593 1466840.1101320074 138.83737469415848 0.0018661125202351306 8.113806995054521e-11 10.090775327169002 0.6736613147325634 FTITPSTTQVVGILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTITPSTTQVVGILK 15 0 P47755 P47755 CAPZA2 F-actin-capping protein subunit alpha-2 0 24081300.0 13706000.0 6187000.0 4188300.0 False True 11397146.278751368 6153669.402976654 5064054.165488808 1.0 0.5399307205918242 0.4443265043399626 23.442169298699568 -13.999999999999998 0.22084235350752593 3.7865524712630374 0.3935985385435291 0.9994987501889775 0.005430879222343608 13.022695419375417 0.14886713238996327 15.832636034803986 0.05261737085552521 1.0000000000000041e-14 13.999999999999998 -3.392953932719508 FTITPSTTQVVGILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTITPSTTQVVGILK 15 0 P47755 P47755 CAPZA2 F-actin-capping protein subunit alpha-2 0 24155500.0 3518400.0 14874000.0 5763100.0 False True 4554638.158032593 14046248.824703189 4714274.934399617 1.0 3.083943957201325 1.0350492774240445 22.11890501339594 -6.642208978168565 2.0361936525084956 2.3604605419969955 1.0435455916635612 0.16325470556455957 0.891159997609686 0.5278058385274823 4.184943991191473 0.35604857199650414 0.9870031088530757 2.279245058120224e-07 6.642208978168565 -1.3169149503334343 FTK(ub)LNESTFDTQITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTKLNESTFDTQITK 15 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 11509500.0 0.0 4277300.0 7232200.0 True False 0.0 3639143.5127848126 6483881.320161055 0.0 FTK(ub)SISIGPISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTKSISIGPISK 12 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 17302100.0 3798000.0 6356200.0 7147900.0 True False 4979214.779884313 5407879.736273546 6408303.875498357 1.0 1.086090874834524 1.2870109362197963 22.247486817142455 -6.9569184137118345 0.47688510457278793 0.9950331096558227 1.3864016042613725 0.9996382761228936 0.0022871660319875994 0.08082087153685964 0.025342479841186785 0.0028152608566573154 0.016576304674085014 1.1042860509003754e-07 6.9569184137118345 0.3913684946055498 FTK(ub)SISIGPISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTKSISIGPISK 12 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 37038500.0 8794200.0 7157000.0 21087300.0 True False 8515032.934701707 10014827.423261937 15563903.52456017 1.0 1.1761349016570504 1.8278148357044957 23.02158067933826 -6.946669096283872 0.5942988058432365 0.9925579152185336 2.0444258884621185 0.9989131997497759 0.011737997914697025 0.08485168750338692 0.04171667958351153 0.012115953041944114 0.05466607214575884 1.1306570725836122e-07 6.946669096283872 1.051867973243585 FTK(ub)SISIGPISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTKSISIGPISK 12 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 40712000.0 14398000.0 0.0 26314000.0 True False 21842818.63479483 0.0 21113026.366164103 1.0 0.0 0.9665889150648261 24.380655700325516 -11.896971356667603 13.712776886342047 0.858346195886999 0.5349650117791782 0.0 0.4791465669934492 0.0 0.0 0.0 0.13639323684422616 1.267735474958765e-12 11.896971356667603 -0.3233811841078208 FTK(ub)SISIGPISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTKSISIGPISK 12 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 26477000.0 3798000.0 12629200.0 10049800.0 True False 5202223.237090758 12071200.184820427 7676244.222127967 1.0 2.320392577303355 1.4755699385212766 22.310696878665347 -10.113600279455262 4.857222314049536 0.9999555546876399 1.897981257918073 0.6010224276784477 0.3448973980478135 240401674.60309252 12.175726105822829 119500.07767162999 0.11806755308176595 7.698386665615577e-11 10.113600279455262 0.8980257032304332 FTK(ub)SISIGPISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTKSISIGPISK 12 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 37050000.0 8794200.0 12348000.0 15907800.0 True False 7312766.949116828 12281478.873113891 19234047.43064316 1.0 1.679457168342708 2.6302010667748794 22.801985954772537 -6.966386670695474 0.33339679990901316 0.8886622448974774 3.452278681083478 0.9999389420707586 0.005224342381002758 0.07749350552306113 0.013217677047922928 0.013709945451215094 0.0827028867557435 1.080471533541112e-07 6.966386670695474 2.5636164361860003 FTK(ub)SISIGPISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTKSISIGPISK 12 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 35800000.0 14398000.0 0.0 21402000.0 True False 18638494.827010382 0.0 17507055.603064436 1.0 0.0 0.9392955689583745 24.151782022417965 -10.055028037646647 13.334326868041824 0.9999999999976751 0.4696477847572022 0.2982812937889039 0.38346581026753795 0.0 0.0 0.37128917701784686 0.12376305808384228 8.809919951506154e-11 10.055028037646647 -0.5303522152404729 FTLAGHTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTLAGHTK 8 0 P61964;V9GZ59;V9GYQ5 P61964 WDR5 WD repeat-containing protein 5 0 6588900.0 1740300.0 1952700.0 2895900.0 False True 2281550.1530891745 1661364.7715649856 2596260.047434312 1.0 0.7281736802127843 1.137936873278471 21.121582936812658 -6.72783967943404 1.7309419162686377 0.836023855521189 1.1376053971844493 0.5492691435964445 0.1142903344096944 0.34031599755821557 1.9965273291161703 0.05234411007225565 0.13021542866940267 1.8713728334202098e-07 6.72783967943404 0.30158154166326034 FTLAGHTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTLAGHTK 8 0 P61964;V9GZ59;V9GYQ5 P61964 WDR5 WD repeat-containing protein 5 0 4311400.0 1740300.0 1124300.0 1446800.0 False True 2383735.9398391414 1074624.7084370852 1105095.6377813239 1.0 0.45081533171396604 0.463598177680661 21.18479299833555 -9.974607171969069 5.472256861872814 1.00000132868332 0.4572067546963276 0.9995842163304892 0.005218575016633498 8.459669287248882e-08 1.583684506602943e-08 0.0050528759530642725 0.0016842878436938 1.0602122747713003e-10 9.974607171969069 -0.5427945739869924 FTLLQSVHIYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTLLQSVHIYK 11 0 P82664 P82664 MRPS10 28S ribosomal protein S10, mitochondrial 0 5208800.0 1972800.0 1797100.0 1438900.0 False True 1910174.5438561246 2514691.4017526954 1062008.9239252852 1.0 1.3164720521697537 0.5559748072976499 20.86527304111947 -6.793698791857947 1.4816389368770264 1.176032785846831 0.5470571633283705 0.8130331411516595 0.1348748722159526 0.22989323896058986 0.9968907918350608 0.07163892226597626 0.16727529311746708 1.608056145550844e-07 6.793698791857947 -0.6289756225184604 FTLLQSVHIYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTLLQSVHIYK 11 0 P82664 P82664 MRPS10 28S ribosomal protein S10, mitochondrial 0 20172600.0 4116000.0 4314600.0 11742000.0 False True 6244272.919906619 3544625.919876331 9421188.553298583 1.0 0.5676603129527111 1.5087727064689982 22.574102164229853 -6.781782111905515 1.5287877490174033 0.7557658518724353 1.5166671425669944 0.7736900763771584 0.18297618772406452 0.24781571598285795 1.1440984388421978 0.09425452878092921 0.22208513717474118 1.6527908051153424e-07 6.781782111905515 0.7609012906945591 FTLLQSVHIYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTLLQSVHIYK 11 0 P82664 P82664 MRPS10 28S ribosomal protein S10, mitochondrial 0 16221700.0 4116000.0 6347500.0 5758200.0 False True 5328243.138489702 5994256.04509906 4710266.684121373 1.0 1.1249967182988088 0.8840187209355662 22.345228486322302 -6.765742070738013 1.5908473397934766 1.0720842698876631 0.882879038753264 0.7139748176951963 0.052626584589413335 0.27337098606236965 1.3647017613166985 0.026086213937968464 0.062339340237179235 1.714975536070615e-07 6.765742070738013 -0.18920523113439913 FTLPPLVFAAYQLAFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTLPPLVFAAYQLAFR 16 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 1692650000.0 974920000.0 237230000.0 480500000.0 False True 1262053158.5462544 224027941.95807 393053930.346344 1.0 0.17751070185991644 0.3114400749958097 30.233125532893006 -10.46077185796985 6.4361623764858935 1.0002556752772387 0.24447538924025014 0.9769750248791305 0.0546764376256253 0.00020065888137338315 1.6811352511471448e-05 0.05295738294226286 0.017646744362832943 3.461211532083633e-11 10.46077185796985 -0.7557802860369885 FTLSANVGDLK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTLSANVGDLKLR 13 1 Q9H269-2;Q9H269;Q5JUA9;Q5JUB0 Q9H269-2 VPS16 Vacuolar protein sorting-associated protein 16 homolog 1 20407900.0 3401600.0 5227300.0 11779000.0 True False 5160475.890270741 4294447.473918685 9450875.487080894 1.0 0.832180513044385 1.8313961130792262 22.299072683979627 -6.86370290283214 1.1667873132014548 0.907877447063544 1.8833422155666775 0.9579899718762069 0.08954542190153783 0.1430413291286231 0.36794018334019196 0.059757918221091846 0.1401364817193899 1.3686647973819402e-07 6.86370290283214 0.9754647685031335 FTLSANVGDLK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTLSANVGDLKLR 13 1 Q9H269-2;Q9H269;Q5JUA9;Q5JUB0 Q9H269-2 VPS16 Vacuolar protein sorting-associated protein 16 homolog 1 6124000.0 2143700.0 1892700.0 2087600.0 True False 1782581.5320122053 1882503.649428463 2524107.508028183 1.0 1.056054724915423 1.415984325372726 20.765536633729464 -6.934416528613522 0.7095986546103666 0.995319921916052 1.4989377852690442 0.9973373893260928 0.009510528668889181 0.09040833274759069 0.06691401079504475 0.008904698854253596 0.03181367828013093 1.1630100600223258e-07 6.934416528613522 0.5036178633529922 FTLSANVGDLK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTLSANVGDLKLR 13 1 Q9H269-2;Q9H269;Q5JUA9;Q5JUB0 Q9H269-2 VPS16 Vacuolar protein sorting-associated protein 16 homolog 1 11070800.0 3401600.0 2790400.0 4878800.0 True False 4403438.255560393 2635111.787041266 3990908.4607153917 1.0 0.5984214230127577 0.906316434816797 22.070199006072077 -9.931667222306377 5.974515259741788 1.0000001025733765 0.7523689289146955 0.46307843069474286 0.12569761221164102 1.7164803496911122e-07 3.096211634827183e-08 0.12170624046784964 0.04056872989610104 1.1703958621241662e-10 9.931667222306377 -0.24763117365868093 FTLWGLETIPGPDAK(ub)VR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTLWGLETIPGPDAKVR 17 1 E9PN81;Q8TDP1 E9PN81 RNASEH2C Ribonuclease H2 subunit C 1 17874200.0 1651100.0 2802100.0 13421000.0 True False 1598686.734266445 3920993.1427584616 9905637.47863037 1.0 2.4526338141897472 6.196109135274432 20.608455836974613 -6.954808280396354 0.503300311275634 0.9271272078226324 7.88398323358242 0.9995265764067064 0.04762770970161602 0.08161057126003136 0.028402427073279952 0.055514359977849405 0.30884265274003625 1.1096645693557532e-07 6.954808280396354 6.956856025759787 FTLWGLETIPGPDAK(ub)VR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTLWGLETIPGPDAKVR 17 1 E9PN81;Q8TDP1 E9PN81 RNASEH2C Ribonuclease H2 subunit C 1 42285200.0 2938900.0 6037300.0 33309000.0 True False 4458526.162369665 4959896.645359798 26725461.55014669 1.0 1.1124520670578861 5.994236789661981 22.088135452195605 -6.911863497162333 0.8829540428040853 0.8576129498703733 6.650923005538431 0.991605896092639 0.2133130314609455 0.10319845109404058 0.13218032563450796 0.17626759809305528 0.49309255125457163 1.2250011681433447e-07 6.911863497162333 5.793310055668058 up FTLWGLETIPGPDAK(ub)VR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTLWGLETIPGPDAKVR 17 1 E9PN81;Q8TDP1 E9PN81 RNASEH2C Ribonuclease H2 subunit C 1 14173600.0 1651100.0 2083500.0 10439000.0 True False 1372962.8061320845 2072275.7719576312 12621746.635517443 1.0 1.5093458924758885 9.193072513796256 20.38886111240889 -6.920355862705003 0.8220833071100342 0.8326277232302906 10.442341039610021 0.9942791740708535 0.2834820046480002 0.09796295072713444 0.1045327454543466 0.24470968583677394 0.7355339904256271 1.201279697642521e-07 6.920355862705003 9.60971331637973 up FTLWWSPTINR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTLWWSPTINR 11 0 Q6P2Q9;I3L3Z8 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 53709400.0 9403400.0 19634000.0 24672000.0 False True 12327948.462655142 16704683.732732564 22119178.110535353 1.0 1.355025435362242 1.7942302547370819 23.555429399961163 -6.968261271173659 0.2967930495563643 0.9208650480267564 2.242090333843908 0.9999654658772428 0.0019089942729563901 0.07687101564869854 0.011038839218847244 0.007404993119238042 0.039526304213426455 1.0758178078745858e-07 6.968261271173659 1.3212252858171518 FTLWWSPTINR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTLWWSPTINR 11 0 Q6P2Q9;I3L3Z8 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 37913200.0 12540000.0 8481200.0 16892000.0 False True 12141924.564048974 11867787.388873706 12467478.450862383 1.0 0.9774222633546118 1.0268123792975408 23.533493779293394 -6.782452502509822 1.5266690493255695 0.9872564206535884 1.0272316120748721 0.7758463479542648 0.009558037044491628 0.2467891016232859 1.1363140178829676 0.004930654269867648 0.011608927845189895 1.65024147343161e-07 6.782452502509822 0.039975191421283696 FTLWWSPTINR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTLWWSPTINR 11 0 Q6P2Q9;I3L3Z8 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 41899000.0 11667000.0 11193000.0 19039000.0 False True 17699691.971951064 9195521.69869183 15275933.304909863 1.0 0.5195300411591397 0.8630620989968547 24.07722091749125 -9.883305493783258 6.464792516300644 1.0000000186356204 0.6912960700779749 0.5184632327014522 0.1402463753318643 3.767151180579309e-08 6.5729776017725875e-09 0.13579297710041033 0.045264323002176345 1.3082613349610078e-10 9.883305493783258 -0.3087039485576455 FTLWWSPTINR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTLWWSPTINR 11 0 Q6P2Q9;I3L3Z8 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 49317400.0 9403400.0 15237000.0 24677000.0 False True 12880091.097329991 14563778.957979053 18848800.838768117 1.0 1.1307201826389324 1.463405863851027 23.618639461484054 -6.955078179718375 0.4999994786146393 0.9933373100806246 1.615137666590698 0.9995418755548382 0.004175498105056908 0.08150847751831332 0.028002622639797085 0.0048967863033123815 0.027443544846430752 1.10897516462499e-07 6.955078179718375 0.6218003565100734 FTLWWSPTINR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTLWWSPTINR 11 0 Q6P2Q9;I3L3Z8 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 32013800.0 12540000.0 6717800.0 12756000.0 False True 10427565.61619307 6681609.878021104 15423220.622919837 1.0 0.6407641173358014 1.4790816179539514 23.31389905472767 -6.790258132606622 1.4952847707495764 0.7992908676203703 1.4880631450082784 0.8021653508136413 0.15274196950833396 0.23496661967887233 1.0378519183285781 0.08040176586440072 0.18820624123046623 1.6208464247926414e-07 6.790258132606622 0.6887722773879081 FTLWWSPTINR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTLWWSPTINR 11 0 Q6P2Q9;I3L3Z8 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 34690000.0 11667000.0 12835000.0 10188000.0 False True 15103161.490952233 12120720.967128223 8333888.537707709 1.0 0.8025287271402954 0.551797618180819 23.8483472395837 -6.967878813220658 0.3046215643572916 1.0411645788089468 0.3052532759846826 0.99996078862801 0.0011484675999511164 0.0769971620968583 0.01148078160078261 0.004067310047085053 0.022379320654111065 1.0767656354875433e-07 6.967878813220658 -0.7359113028242641 FTMVQVWPVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTMVQVWPVR 10 0 P38606;P38606-2;C9JVW8;C9JA17 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 36503600.0 20099000.0 7875900.0 8528700.0 False True 16713209.036671788 7833470.963456258 10312011.737746678 1.0 0.4686993949676698 0.6169977121162231 23.99448543033371 -10.565611161579488 9.671904769683987 1.0000287536260324 0.5428485535419867 0.9268486511318405 0.06054253445456466 3.754001735092507e-05 1.6860096302427324e-06 0.058623720043944616 0.019540018973309828 2.7188724771587676e-11 10.565611161579488 -0.4571802000840457 FTNMLGQPGSTALDLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTNMLGQPGSTALDLFK 17 0 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 0 6675150.0 898750.0 3505900.0 2270500.0 False True 1178269.9535073796 2982833.3858911665 2035570.4401739025 1.0 2.531536492984572 1.7275925895543542 20.16823868231962 -10.1580834827022 5.921242184353908 0.99998831261113 2.1295645412694846 0.7246803817262666 0.3282087242043082 5.0639668371469316e-05 7.2009120313175265e-06 0.31779000889565046 0.10592891024359449 6.948907286665713e-11 10.1580834827022 1.1295762286583546 FTNMLGQPGSTALDLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTNMLGQPGSTALDLFK 17 0 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 0 13620400.0 5257300.0 3123400.0 5239700.0 False True 5090409.889200529 4370589.908315821 3867265.3823693926 1.0 0.858592923447711 0.7597159102204957 22.27935039877017 -6.974958480745465 0.07289652348206589 1.3980085843125656 0.2178270595735811 0.9999999281263248 2.5797498626438862e-05 0.07472340197696671 0.0021069491769799453 0.013355842574141564 0.02063919899122562 1.059354996386537e-07 6.974958480745465 -1.1801815247389844 FTNMLGQPGSTALDLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTNMLGQPGSTALDLFK 17 0 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 0 13199670.0 898750.0 2908300.0 9392620.0 False True 1231042.162805508 2779801.6895380015 7174276.603081014 1.0 2.258088125270151 5.827807381293143 20.23144874384251 -6.952696243070762 0.5284159887115839 0.9430522211911089 7.304455676467117 0.9993962364361588 0.05024570591843855 0.08242081556475138 0.031619029085272365 0.056188457779355876 0.29513736147812175 1.1150741729759006e-07 6.952696243070762 6.361403455276008 FTNMLGQPGSTALDLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTNMLGQPGSTALDLFK 17 0 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 0 13365800.0 5257300.0 2436000.0 5672500.0 False True 4371677.887879727 2422876.7844918557 6858593.523323358 1.0 0.554221250199876 1.5688698250935844 22.059755674204446 -6.787270420328669 1.5070976776136187 0.7499680051129313 1.5788834119851325 0.7924018351222565 0.1891970816895931 0.2394421307994464 1.0744168947548889 0.09882630781096122 0.23185724084922646 1.632035418779766e-07 6.787270420328669 0.8289154068722012 FTPGTFTNQIQAAFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTPGTFTNQIQAAFR 15 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 153553000.0 26275000.0 77717000.0 49561000.0 False True 34446779.44746194 66121926.53849335 44432903.142681666 1.0 1.919538708672089 1.2899000677392938 25.037865770729862 -10.390209748525919 5.486715125608358 0.9997272230829851 1.6047193882056867 0.5515459655080999 0.25704889877082265 0.0008580827853071359 9.536621482616428e-05 0.2489957999082966 0.0829621753416933 4.0718357536916555e-11 10.390209748525919 0.6049921651227016 FTPGTFTNQIQAAFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTPGTFTNQIQAAFR 15 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 293553000.0 106080000.0 68233000.0 119240000.0 False True 102712548.46525636 95478792.73039435 88007466.87667735 1.0 0.9295728141989495 0.8568326673974683 26.614037206603943 -6.970720198629498 0.24036870468264201 1.025999797059612 0.7583008413353008 0.9999874565903576 0.00020693122739007328 0.07606972026128087 0.008189686594115744 0.0017342344130493914 0.007086767689684145 1.0697438573492031e-07 6.970720198629498 -0.2676989557243111 FTPGTFTNQIQAAFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTPGTFTNQIQAAFR 15 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 307266000.0 50693000.0 175490000.0 81083000.0 False True 76904987.15471958 144172438.39037183 65056909.51005864 1.0 1.8746825625277297 0.8459387605016481 26.196573821697562 -6.681466991211588 1.8967896062444425 1.5526924868953298 0.8498184714893809 0.33082169064863653 0.3705928396068016 0.4352599528850325 3.0289591605705826 0.15670597319353644 0.41250903901048486 2.0822506618004284e-07 6.681466991211588 -0.7028740154059488 FTPGTFTNQIQAAFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTPGTFTNQIQAAFR 15 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 226315000.0 26275000.0 74460000.0 125580000.0 False True 35989577.55517635 71170110.9937075 95920590.40128452 1.0 1.9775200440904082 2.6652324622101142 25.101075832252754 -7.906353748939999 0.15441999621370944 9.87258672645821e-20 4.009967476509471 0.999951112472416 0.004777264477392874 0.12067206055014752 0.024330629579420716 0.24560277255867652 0.32137240138653134 1.2406413475902379e-08 7.906353748939999 4.009967476509471 FTPGTFTNQIQAAFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTPGTFTNQIQAAFR 15 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 224128000.0 106080000.0 49779000.0 68269000.0 False True 88210220.14081024 49510830.64664208 82543732.25980824 1.0 0.5612822478802093 0.9357615492631516 26.39444248203822 -10.11436552533565 7.454004278078524 1.0000000629472863 0.7485218985716805 0.375503211321225 0.15288053460368792 1.5985399389464784e-07 1.9234543433107265e-08 0.14802597861756817 0.049341980373280844 7.684833715407357e-11 10.11436552533565 -0.2514781643756058 FTPGTFTNQIQAAFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTPGTFTNQIQAAFR 15 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 260943000.0 50693000.0 129120000.0 81130000.0 False True 65623087.80842032 121934358.4943978 66365172.46409766 1.0 1.8581015091879294 1.0113082861605625 25.96770014379001 -10.222628424009176 4.049506212153524 0.9996929606674195 1.4347048977282688 0.260013922387319 0.34570188585690026 245485488.7114232 295757782.15856194 864105.4353755513 0.12651394335350985 5.989238063357567e-11 10.222628424009176 0.4350119370608493 FTPSPVDFTITPETLQNVK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTPSPVDFTITPETLQNVKER 21 1 A8MTY9;O14972;O14972-2;A8MY26 A8MTY9 DSCR3 Down syndrome critical region protein 3 1 6390900.0 1337100.0 2450400.0 2603400.0 True False 1752951.0484948172 2084809.8715843875 2334025.1415761863 1.0 1.189314369830534 1.3314833540732995 20.741354278439406 -6.974283873417872 0.11698344755717871 0.7320953878416125 1.7923476719837963 0.9999995028824571 9.556166553532346e-05 0.07493539576868413 0.0034755534390313904 0.010375237967331835 0.020852243764326924 1.0610018144024893e-07 6.974283873417872 1.0602522841421838 FTPSPVDFTITPETLQNVK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTPSPVDFTITPETLQNVKER 21 1 A8MTY9;O14972;O14972-2;A8MY26 A8MTY9 DSCR3 Down syndrome critical region protein 3 1 9879700.0 1337100.0 2061900.0 6480700.0 True False 1831462.0037688394 1970798.4402085068 4950092.13420612 1.0 1.0760793487131792 2.7028090804066185 20.804564339962297 -6.9166614748866175 0.8491121752872799 0.9596097286109869 2.9460018142785707 0.9932023099465797 0.06475426342173682 0.10017631163213239 0.11608507953621211 0.054827631885196224 0.15934178469889224 1.2115421419411474e-07 6.9166614748866175 1.9863920856675836 up FTPTVPHCSLATLIGLCLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTPTVPHCSLATLIGLCLR 19 0 H0YKV4;Q9H5X1 H0YKV4 FAM96A MIP18 family protein FAM96A 0 52782000.0 15505000.0 19641000.0 17636000.0 False True 23522218.567335278 16135910.094166579 14150236.869866608 1.0 0.68598589235856 0.6015689731544579 24.487520802835867 -13.999999999999998 0.18437346294027981 2.6518884909429765 0.537455252323479 0.9994935099255325 0.0038579695868517596 12.26446899566173 0.13615002758285843 7.2657955497289946 0.06076196687955569 1.0000000000000041e-14 13.999999999999998 -2.1144332386194975 FTPTVPHCSLATLIGLCLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTPTVPHCSLATLIGLCLR 19 0 H0YKV4;Q9H5X1 H0YKV4 FAM96A MIP18 family protein FAM96A 0 34182400.0 15505000.0 5495400.0 13182000.0 False True 20071528.14924264 5189576.15915516 10783011.25874195 1.0 0.2585541130983083 0.5372292123730911 24.258647124928316 -10.384796506261795 5.897232660441247 1.00014180008943 0.3978916627376129 0.8615786060864884 0.11376863287377952 0.0002121533806013494 2.2131634283058546e-05 0.11018153644943714 0.03671866837007747 4.122906574351353e-11 10.384796506261795 -0.6022501373518171 FTQAGSEVSALLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTQAGSEVSALLGR 14 0 P06576;H0YH81;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 119863000.0 21108000.0 51891000.0 46864000.0 False True 27672792.410162766 44149065.06953375 42014962.83123087 1.0 1.595396099358593 1.5182769490151264 24.721964895186076 -10.589597341318226 6.248071003754846 0.9984812010541475 1.556836524186611 0.9858183352774315 0.031483761289746226 0.0006675934458652532 4.3850539916513e-05 0.03055252979296071 0.010161340262596344 2.5727800454489836e-11 10.589597341318226 0.5583553231324634 FTQAGSEVSALLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTQAGSEVSALLGR 14 0 P06576;H0YH81;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 166842000.0 48795000.0 21141000.0 96906000.0 False True 47246029.43403258 29582711.5488586 71523411.48231542 1.0 0.6261417499678689 1.513850207924461 25.49368975425364 -6.7922943806986105 1.487038665583706 0.7916645304969107 1.5239092884102268 0.8086692339713522 0.15917682030891128 0.23197063783329125 1.0132704276473212 0.08424153057492856 0.19691537611106608 1.613264656282571e-07 6.7922943806986105 0.7322447579133161 FTQAGSEVSALLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTQAGSEVSALLGR 14 0 P06576;H0YH81;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 159083000.0 9280000.0 134380000.0 15423000.0 False True 14078438.458875965 110398839.0842679 12374637.289858963 1.0 7.841696322127635 0.8789779723089378 23.74698398735082 -6.650193132627776 2.0077437511553944 5.4389633941954525 0.908216125264254 0.19481025972721167 2.9199870372338697 0.5081043462560725 3.926106553789632 1.1793768634111097 3.2344842783705245 2.2377257909639167e-07 6.650193132627776 -4.530747268931199 FTQAGSEVSALLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTQAGSEVSALLGR 14 0 P06576;H0YH81;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 130335000.0 21108000.0 63931000.0 45296000.0 False True 28912198.02225166 61106317.02845429 34598017.700402796 1.0 2.1135133683514864 1.1966581604682966 24.785174956708968 -10.2546360810909 4.490639809140621 0.9997054661978112 1.655085764415777 0.4049974977748967 0.3743045712412772 264537453.72978765 407.15570955273967 805653.9551278107 0.12813441065088363 5.563702748316704e-11 10.2546360810909 0.6553802982179658 FTQAGSEVSALLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTQAGSEVSALLGR 14 0 P06576;H0YH81;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 89292000.0 48795000.0 20793000.0 19704000.0 False True 40575204.485019125 20680983.981912643 23824015.29899755 1.0 0.5096951264792349 0.5871569989941438 25.274095029687917 -10.715745234269647 6.847761497729692 1.0051076369781098 0.5484260627367491 0.9784076766802655 0.031623677030341246 0.0024777529440623003 0.00010285287901005518 0.03076614812037133 0.010206497873696142 1.9242201834979944e-11 10.715745234269647 -0.4566815742413607 FTQAGSEVSALLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTQAGSEVSALLGR 14 0 P06576;H0YH81;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 53589000.0 9280000.0 27133000.0 17176000.0 False True 12013142.936147831 25623024.698176082 14050144.240642697 1.0 2.1329159932889663 1.1695643942074043 23.51811030944327 -6.606619978264328 2.166405288067999 1.75863350315356 1.172924759287044 0.0399133112399771 0.48886255308084503 0.622083858723532 5.527647722298579 0.18667695842720253 0.5429867548563189 2.4738879302392853e-07 6.606619978264328 -0.5857087438665161 FTQISPVWLQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTQISPVWLQLK 12 0 Q9BWS9-3;Q9BWS9;E9PPA0;Q9BWS9-2;E9PI70;E9PIP0;E9PRL3;E9PPH0 Q9BWS9-3 CHID1 Chitinase domain-containing protein 1 0 17961100.0 4458800.0 8222300.0 5280000.0 False True 5845529.979080617 6995564.8902743645 4733676.249336353 1.0 1.1967374926327252 0.8097941959543014 22.478902400501905 -6.768486594095003 1.5802010756594305 1.113062728383052 0.8077395434262041 0.7247351626656868 0.08288342594144392 0.2688945710970568 1.3248708103887972 0.04134850974691472 0.0985657343678298 1.704171923286462e-07 6.768486594095003 -0.30532318495684796 FTQISPVWLQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTQISPVWLQLK 12 0 Q9BWS9-3;Q9BWS9;E9PPA0;Q9BWS9-2;E9PI70;E9PIP0;E9PRL3;E9PPH0 Q9BWS9-3 CHID1 Chitinase domain-containing protein 1 0 44987900.0 32321000.0 3497900.0 9169000.0 False True 31294987.54662093 4894629.711307524 6767363.835896126 1.0 0.1564029927801016 0.21624433707840957 24.899428266394214 -10.014755730222078 6.878436102437803 1.000000135991554 0.1863236649293963 0.9959598042199325 0.02443012650884826 5.094596828842055e-08 7.276629237307997e-09 0.023654372155766663 0.007884789426208457 9.665943890246478e-11 10.014755730222078 -0.8136764710621577 FTQISPVWLQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTQISPVWLQLK 12 0 Q9BWS9-3;Q9BWS9;E9PPA0;Q9BWS9-2;E9PI70;E9PIP0;E9PRL3;E9PPH0 Q9BWS9-3 CHID1 Chitinase domain-containing protein 1 0 31005800.0 4458800.0 12284000.0 14263000.0 False True 6107338.854539305 11741252.26224419 10894373.155705692 1.0 1.9224825315722338 1.7838167187347733 22.542112462024797 -10.087180980236038 4.377442239915329 0.9999148845504289 1.853149625224314 0.9805719535032857 0.056610081294151925 7387215.356977061 4255695.537343476 5643.502500400087 0.01937913642008378 8.181237865856038e-11 10.087180980236038 0.8532347406738852 FTQVTPTSLSAQWTPPNVQLTGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTQVTPTSLSAQWTPPNVQLTGYR 24 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 21027400.0 11423000.0 3999200.0 5605200.0 False True 11060383.11763406 5596101.41555249 4137029.9676044206 1.0 0.5059590934630807 0.37404038572665443 23.39889802377492 -13.999999999999998 0.18533480934107188 3.6070836573973497 0.27482621844310273 0.9994926643339149 0.0060685374756048 12.278429709056898 0.13650896589947345 11.543266251341576 0.09420487697080636 1.0000000000000041e-14 13.999999999999998 -3.332257438954247 FTQVTPTSLSAQWTPPNVQLTGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTQVTPTSLSAQWTPPNVQLTGYR 24 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 3316590.0 1247100.0 774690.0 1294800.0 False True 1708186.5716102945 740461.6342427515 988994.9072430597 1.0 0.4334781964388843 0.5789735873586348 20.70403412697402 -10.33127965507017 8.692057714034346 1.0000007602780983 0.5062258918989154 0.9388628397312576 0.059398244613359595 8.751430414247094e-07 6.72915844935725e-08 0.057512191731257295 0.01917070101512468 4.663589812564691e-11 10.33127965507017 -0.49377486837918283 FTQVTPTSLSAQWTPPNVQLTGYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTQVTPTSLSAQWTPPNVQLTGYR 24 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 20100900.0 11423000.0 5228200.0 3449700.0 False True 9498730.624702804 5200034.648883558 4171016.3203893546 1.0 0.5474452170861784 0.4391130231172186 23.179303299209195 -13.999999999999888 0.20083053779382262 3.52367388124676 0.3693301019878568 0.9994869837610134 0.005502333244797383 12.547437454883006 0.14209481145477612 12.44294471029827 0.06855552684680095 1.0000000000002576e-14 13.999999999999888 -3.154343779258903 FTVAELK(ub)QLVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTVAELKQLVAR 12 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 3767130.0 979730.0 1769500.0 1017900.0 True False 948629.0074270891 2476070.577820595 751281.4536545603 1.0 2.6101569300904006 0.7919655078777497 19.855484458636848 -6.6730012095029965 1.9268766176461862 2.0250916138427786 0.7992301442336097 0.2923880613890595 0.6834894537161976 0.4542379851683945 3.254292572011176 0.28528546253241266 0.7592013428132207 2.1232385488075125e-07 6.6730012095029965 -1.225861469609169 FTVDEK(ub)NYTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTVDEKNYTK 10 1 Q9BV57;Q9BV57-2;A0A0G2JQN5 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 10465400.0 5131500.0 2686000.0 2647900.0 True False 6727446.193516696 2285259.2699459945 2373920.70845033 1.0 0.3396919431549405 0.35287100634682145 22.681627516482017 -10.004338047213674 5.650807260268165 1.0000015455995468 0.3462814747505244 0.9996952688177311 0.0053803300192601005 14838809.194801034 4.985296421843059 298.410347408593 0.0018418300737871396 9.900609987556655e-11 10.004338047213674 -0.6537200708490224 FTVDEK(ub)NYTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTVDEKNYTK 10 1 Q9BV57;Q9BV57-2;A0A0G2JQN5 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 16849040.0 4380900.0 4747540.0 7720600.0 True False 4241830.727483419 6643257.480094043 5698343.246964734 1.0 1.5661297932167453 1.3433688454478783 22.016255619826588 -10.067681650487788 4.451082657357871 0.9999690791856606 1.4547493192927268 0.8474806171540201 0.09094177622800588 13844012.48589243 15656541.815893807 3487.2725500788783 0.03113178964257365 8.556937295181625e-11 10.067681650487788 0.4547802401070662 FTVDEK(ub)NYTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTVDEKNYTK 10 1 Q9BV57;Q9BV57-2;A0A0G2JQN5 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 51040500.0 9770700.0 9085000.0 32184800.0 True False 14822866.233851198 7463710.768571023 25823460.172901057 1.0 0.5035268247598454 1.742136761237691 23.821321106561356 -6.7979361399105995 1.4644916736508204 0.7253535065152537 1.7583450240247636 0.8260145797115289 0.21229718543618017 0.22371654160073692 0.9474954520316338 0.11405786562483611 0.26557733660259286 1.5924428678745852e-07 6.7979361399105995 1.03299151750951 FTVDEK(ub)NYTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTVDEKNYTK 10 1 Q9BV57;Q9BV57-2;A0A0G2JQN5 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 11276600.0 5131500.0 2701300.0 3443800.0 True False 7028754.22357327 2581947.633995458 2630445.36728734 1.0 0.36734071954544034 0.37424062410167436 22.74483757800491 -10.081503544886315 7.72656304949658 1.000000050347092 0.370790671824479 0.9999098180166971 0.002816874239446379 2.444999565439005e-09 2.840407780838743e-10 0.0027274269982828538 0.000909142251478036 8.288891505187138e-11 10.081503544886315 -0.629209378522613 FTVDEK(ub)NYTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTVDEKNYTK 10 1 Q9BV57;Q9BV57-2;A0A0G2JQN5 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 17739400.0 4380900.0 6816600.0 6541900.0 True False 3642912.456776726 6779877.622810832 7909781.043671951 1.0 1.8611146172888586 2.1712794741904338 21.796660895260864 -10.388874945204355 0.2251826157024469 1.9162465034933255e-16 2.377556859459235 0.9992533386389258 0.013539386008517519 2.0186519500940823 0.11096556144572284 1.3210224368176293 0.16158591074646003 4.084369785470213e-11 10.388874945204355 2.377556859459235 FTVDEK(ub)NYTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTVDEKNYTK 10 1 Q9BV57;Q9BV57-2;A0A0G2JQN5 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 33601300.0 9770700.0 12667600.0 11163000.0 True False 12648363.759290881 11962636.924284665 9131448.542052533 1.0 0.9457853325492387 0.7219470214354808 23.592447428653806 -6.9441475595028495 0.6197799837265863 1.0024502104135469 0.6534281095900186 0.9986582098782534 0.00440845736820697 0.08592445966482028 0.046368994529379204 0.0044405421928562575 0.018941928202929743 1.1372408217791428e-07 6.9441475595028495 -0.34902210082352825 FTVLFPSGTPLPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTVLFPSGTPLPAR 14 0 Q0VDF9 Q0VDF9 HSPA14 Heat shock 70 kDa protein 14 0 14048300.0 3394700.0 4214900.0 6438700.0 False True 4450484.574321569 3586053.3495515143 5772485.088371591 1.0 0.8057669428273823 1.2970464208948633 22.085530996394272 -6.799426825338603 1.4581456447063073 0.8927563776493185 1.3037416450965202 0.8305248403118695 0.08316741825418053 0.22156785142947028 0.9301000807843253 0.04487078044378482 0.10439446828604702 1.5869862891497974e-07 6.799426825338603 0.41098526744720176 FTVLFPSGTPLPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTVLFPSGTPLPAR 14 0 Q0VDF9 Q0VDF9 HSPA14 Heat shock 70 kDa protein 14 0 7571400.0 3394700.0 0.0 4176700.0 False True 4649812.328318072 0.0 3190249.4818366445 1.0 0.0 0.6861028481531469 22.148741057917164 -10.462174733912295 8.198449949953242 1.0000255975175725 0.343051427004492 0.5500415260671903 0.28010031484090964 0.00013105749376746145 8.597413631616767e-06 0.2712164681805306 0.09040198788719142 3.45004902238442e-11 10.462174733912295 -0.6569741705130805 FTVLLMPNGPMR ddPTM_RPMI8226_Bortezomib_1h_R1 3 FTVLLMPNGPMR 12 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 293840400.0 82351300.0 119858600.0 91630500.0 False True 107963351.79112354 101976164.08516344 82149454.84182101 1.0 0.944544258707867 0.7609013010336636 26.685966431099377 -6.949211443845594 0.5674388867545852 1.0023147198321944 0.6942415035507504 0.999137905671149 0.0030001704928748984 0.08380402833601591 0.03728542386615071 0.0031878606982284788 0.01529158035313865 1.1240575736810163e-07 6.949211443845594 -0.308073216281444 FTVLLMPNGPMR ddPTM_RPMI8226_Bortezomib_2h_R1 3 FTVLLMPNGPMR 12 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 177489700.0 81251300.0 50627600.0 45610800.0 False True 78672021.95621297 70843464.6994462 33663963.18532999 1.0 0.9004912157828616 0.4279026056310917 26.229347327117885 -6.940959655208945 0.6505765540958437 1.0052293592499606 0.29678116972046825 0.9982868869300004 0.01032937388141635 0.08733160325088737 0.05263676770227318 0.010129524547935094 0.04050587213619834 1.1456193614644687e-07 6.940959655208945 -0.7084481895294923 down FTVLLMPNGPMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 FTVLLMPNGPMR 12 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 123622300.0 56913100.0 25857900.0 40851300.0 False True 86341333.60494101 21243355.716305166 32777022.64923916 1.0 0.2460392355474283 0.37962145453082796 26.36354804066131 -10.320888584552758 12.367395246350762 1.0000000027429754 0.3128303450996816 0.9724391218222409 0.0545347125363423 4.11675903111753e-09 2.544840237093903e-10 0.052803008360865336 0.01760100278695521 4.776517964273451e-11 10.320888584552758 -0.6871696576432937 FTVLLMPNGPMR ddPTM_RPMI8226_Carfilzomib_1h_R1 3 FTVLLMPNGPMR 12 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 377050600.0 82351300.0 107901500.0 186797800.0 False True 112798801.07020332 103134054.9474553 142680006.8614517 1.0 0.9143187158812716 1.2649071223075412 26.74917649262227 -6.842118820335997 1.2727296085269748 0.9544276150324077 1.276914769980522 0.9280005986979502 0.04004273977956743 0.1663425247724029 0.5225205656791608 0.024662798753464055 0.056847892380924775 1.4384049855367418e-07 6.842118820335997 0.3224871549481142 FTVLLMPNGPMR ddPTM_RPMI8226_Carfilzomib_2h_R1 3 FTVLLMPNGPMR 12 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 194126300.0 81251300.0 49530900.0 63344100.0 False True 67564055.99290162 49264067.21058615 76589058.43997318 1.0 0.7291460893905172 1.1335769783865512 26.00975260255216 -6.726213294943662 1.7367851348454926 0.83631931159877 1.1331856072354518 0.5417179888032508 0.11389861320402886 0.34339283974186524 2.0274021018641406 0.052004952554229024 0.12961608802281607 1.8783940550068518e-07 6.726213294943662 0.29686629563668177 FTVLLMPNGPMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FTVLLMPNGPMR 12 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 157479100.0 56913100.0 65696200.0 34869800.0 False True 73675129.87492178 62040148.71839887 28523854.194362 1.0 0.8420772223099489 0.38715716202722583 26.13467436275376 -6.952359713055236 0.5323089317572337 1.007057925652942 0.20144315266186147 0.9993736851859197 0.006501846221370152 0.0825518397832584 0.032146412625680625 0.007229324490082702 0.03763099437831562 1.1159385665447664e-07 6.952359713055236 -0.8056147729910805 down FTVLPNIDPEIDEKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTVLPNIDPEIDEKK 15 1 O43196-3;O43196-2;O43196;O43196-4;A0A024RCV8;A0A0G2JK88;A0A140T982;A0A140T9J3;A0A0G2JK42;H7C2J4;A0A140T927;A2ABF0;A0A0G2JHB4;A0A0G2JJ70;A0A140T9I9;A2ABE9;A0A140T9P6;A0A140T940;A0A0G2JIC1 O43196-3 MSH5 MutS protein homolog 5 1 11232500.0 2128200.0 2718200.0 6386100.0 True False 2060641.4559177854 3803591.435225735 4713388.831106576 1.0 1.845828843393651 2.2873405839577696 20.974662072372976 -9.510616422386397 0.1750996334016121 8.445327938528588e-20 2.829074732270013 0.9996441219037416 0.01007612148932711 0.9553650250024345 0.07012981517590443 0.7892570010086871 0.301989349070102 3.085912286721211e-10 9.510616422386397 2.829074732270013 FTVNLSGCPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTVNLSGCPR 10 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 16751600.0 6264300.0 4336900.0 6150400.0 False True 8212557.963567487 3689851.425103792 5514015.6068027215 1.0 0.4492938060799929 0.6714126866761821 22.96940021721957 -10.242589390972094 5.5542441664330875 1.0000273061463703 0.560353246378072 0.8393230354269859 0.090679653283204 3.066362174609743e-05 4.181603829707315e-06 0.08780563915062081 0.029266732250466863 5.720192036387651e-11 10.242589390972094 -0.4396740597682982 FTVNLSGCPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTVNLSGCPR 10 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 13189400.0 6264300.0 3256500.0 3668600.0 False True 8580380.996342191 3112617.0621945783 2802152.2371886657 1.0 0.3627597729659655 0.3265766681436664 23.03261027874246 -13.740062372954009 0.41054854949051106 9.999999999999034 0.32493493512746413 0.9998480045964994 0.0038129895794785933 22.69540655518251 0.2121202440013885 181.19404365978147 0.009001117940755967 1.819439533696371e-14 13.740062372954009 -9.67506506487157 FTVTVTMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTVTVTMR 8 0 A2IDC7;Q4TT37;A2IDC6;Q13084 A2IDC7 MRPL28 39S ribosomal protein L28, mitochondrial 0 35552500.0 9560500.0 12520000.0 13472000.0 False True 14503977.466172805 10285708.180793526 10809253.29501263 1.0 0.7091646553355848 0.7452613133344098 23.78994525299243 -10.236248350051811 8.171764150310448 1.0000001565400707 0.7272129844487606 0.9870377117058035 0.014736398919479032 4.204044634077419e-08 3.928789400561448e-09 0.014268465191478076 0.004756152299850945 5.80432403997142e-11 10.236248350051811 -0.2727871720913101 FTVTVTMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTVTVTMR 8 0 A2IDC7;Q4TT37;A2IDC6;Q13084 A2IDC7 MRPL28 39S ribosomal protein L28, mitochondrial 0 21724500.0 9560500.0 12164000.0 0.0 False True 12376255.715629451 11487062.706984626 0.0 1.0 0.9281533099286321 0.0 23.561071575084878 -7.086759060785717 1.005477678132742 1.003272900787246 2.745871245132461e-17 0.9892030726139577 0.047321446647383636 0.08440301688446572 0.16276141484950415 0.038739065693528606 0.06864495790466052 8.189189844992142e-08 7.086759060785717 -1.003272900787246 down FTVVLHIFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTVVLHIFR 9 0 O43824 O43824 GTPBP6 Putative GTP-binding protein 6 0 16596600.0 3223800.0 9161800.0 4211000.0 False True 4890740.291349596 7526805.208529881 3378694.0042531327 1.0 1.5389909829893798 0.690834884491645 22.221621425876794 -6.734970508287753 1.7048313524064453 1.322541516580828 0.690834167115702 0.5823138835642141 0.22650400917006347 0.32697512859220906 1.863876246781529 0.10518707055279666 0.25958620434384905 1.8408970073434024e-07 6.734970508287753 -0.6317073494651261 FTVVLHIFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTVVLHIFR 9 0 O43824 O43824 GTPBP6 Putative GTP-binding protein 6 0 7433700.0 3223800.0 4209900.0 0.0 False True 4173272.650598417 3975615.364200478 0.0 1.0 0.9526373417347662 0.0 21.992747747969243 -7.063177445392917 1.0341484775677496 1.0087686059143468 2.934672948256776e-20 0.9884692860795785 0.049464812304379914 0.08462318841784264 0.17362825599214346 0.03987337226991726 0.07110761678136204 8.646145796768342e-08 7.063177445392917 -1.0087686059143468 down FTVVVATQLPESTSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTVVVATQLPESTSLR 16 0 Q13564;Q13564-4;Q13564-3;Q13564-2;J3QRA5;J3KRK3 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 0 36203000.0 10006000.0 12856000.0 13341000.0 False True 15179833.536585413 10561746.355613526 10704145.50243198 1.0 0.6957748469479798 0.7051556577767186 23.855652634328585 -9.997772510996192 4.967964040591694 1.0000030774523616 0.7004652523771558 0.9992649290915824 0.0038296999987258245 1.3334314631881468e-07 2.689412842590191e-08 0.0037081299950612284 0.0012360303575630566 1.0051421587245883e-10 9.997772510996192 -0.29953782507520577 FTVVVATQLPESTSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTVVVATQLPESTSLR 16 0 Q13564;Q13564-4;Q13564-3;Q13564-2;J3QRA5;J3KRK3 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 0 26195400.0 10006000.0 9902800.0 6286600.0 False True 12952964.2477473 9351700.474739177 5142503.3059632145 1.0 0.7219737734060038 0.39701362619429503 23.626778956421035 -6.9690713021534645 0.2794770926812505 1.0720424596601217 0.03704975590359602 0.9999742056428395 0.0012514908719077364 0.07660520322575014 0.010104140678463552 0.006020541524563225 0.029847001698080355 1.0738131000112653e-07 6.9690713021534645 -1.0349927037565256 down FTVWLHGVLDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTVWLHGVLDK 11 0 Q6PJT7;Q6PJT7-5;Q6PJT7-9;Q6PJT7-2;Q6PJT7-11;Q6PJT7-10;Q6PJT7-3;Q6PJT7-4;G3V256;A0A3B3IT62;G3V3Y4;G3V3R9;G3V572;G3V240;G3V473 Q6PJT7 ZC3H14 Zinc finger CCCH domain-containing protein 14 0 39314000.0 10546000.0 13676000.0 15092000.0 False True 15999053.015873464 11235410.948924294 12109059.584941426 1.0 0.7022547483139833 0.7568610200195862 23.931483178715716 -10.610667302596024 6.492676128765748 1.0008021640866087 0.7295578841667865 0.9703300260968233 0.022292917072417616 0.00025958494252815626 1.5565972209097628e-05 0.021645934219721528 0.007195008046654711 2.4509401000360442e-11 10.610667302596024 -0.27124427991982225 FTVWLHGVLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTVWLHGVLDK 11 0 Q6PJT7;Q6PJT7-5;Q6PJT7-9;Q6PJT7-2;Q6PJT7-11;Q6PJT7-10;Q6PJT7-3;Q6PJT7-4;G3V256;A0A3B3IT62;G3V3Y4;G3V3R9;G3V572;G3V240;G3V473 Q6PJT7 ZC3H14 Zinc finger CCCH domain-containing protein 14 0 29229200.0 10546000.0 10269000.0 8414200.0 False True 13652004.89273867 9697521.122823521 6882901.936982747 1.0 0.7103367746360472 0.5041678486830661 23.702609500808165 -7.725177942241823 0.13368912757283705 1.3647705960493637 7.501132755515734e-15 0.999982513635631 0.0008504360204444365 0.13440682243077992 0.01647303401531554 0.06487874635563341 0.09125134440459895 1.8828774653987594e-08 7.725177942241823 -1.3647705960493561 FTYCSQVLGLHCYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTYCSQVLGLHCYK 14 0 Q14258 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 0 46323000.0 13889000.0 14788000.0 17646000.0 False True 18208613.501267318 12581688.043172527 15820161.192384355 1.0 0.6909745238041789 0.8688284361290481 24.11811773638898 -10.193843670446553 5.247499429601472 1.000012951252602 0.7799014807218834 0.6712640215679655 0.07260855565921395 1.1002190109648836e-05 1.6902263194621386e-06 0.07030706658607619 0.023434310571652687 6.399651572281261e-11 10.193843670446553 -0.22011147053071856 FTYCSQVLGLHCYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTYCSQVLGLHCYK 14 0 Q14258 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 0 17065800.0 4593800.0 7535400.0 4936600.0 False True 6969130.451765548 6190648.99565108 3960878.846211354 1.0 0.8882957549004914 0.5683462052583491 22.732547229552043 -6.952486809140601 0.5308414930594099 1.0050157994242728 0.43708079175174164 0.9993822631049145 0.0045465965461048705 0.08250227969688384 0.031946674951111864 0.005066132925711205 0.02646102501526514 1.1156120354056466e-07 6.952486809140601 -0.5679350076725311 FTYCSQVLGLHCYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTYCSQVLGLHCYK 14 0 Q14258 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 0 44836200.0 13889000.0 9800200.0 21147000.0 False True 19024138.636112053 9367194.7590724 16152514.13613604 1.0 0.4923846981061933 0.8490536389108819 24.181327797911873 -10.045216578565748 6.164870586253246 1.0000004280063564 0.6707191685085312 0.5319284942801774 0.145609485345104 8.564285685757463e-07 1.3290373569988e-07 0.1409859607167912 0.04699525931594688 9.011216446634422e-11 10.045216578565748 -0.32928125949782516 FTYCSQVLGLHCYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTYCSQVLGLHCYK 14 0 Q14258 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 0 19763000.0 4593800.0 8233200.0 6936000.0 False True 5946764.6573357545 7775015.182435548 5673719.16936991 1.0 1.3074361657888238 0.954085035527844 22.503673551644493 -6.676730569130671 1.9138704217235296 1.1950894035342854 0.9554733826048878 0.30910127694869427 0.13039332376073068 0.4458052630818716 3.15431895106179 0.05473106393899189 0.14493750643503112 2.1050840025557858e-07 6.676730569130671 -0.2396160209293976 FTYTPGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FTYTPGTR 8 0 Q12968-5 Q12968-5 NFATC3 Nuclear factor of activated T-cells, cytoplasmic 3 0 108851800.0 14100000.0 7509800.0 87242000.0 False True 18485236.544594243 6389367.112971132 78215034.72435662 1.0 0.3456470301344137 4.231216329618976 24.13987016916648 -6.86357715419435 1.1674528142251246 0.6409732310735125 4.432713997281494 0.9578463725205014 0.34874151113268975 0.14316647630985296 0.3687593325398967 0.2326154083267637 0.5454006573466298 1.3690611474625258e-07 6.86357715419435 3.791740766207982 up FTYTPGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FTYTPGTR 8 0 Q12968-5 Q12968-5 NFATC3 Nuclear factor of activated T-cells, cytoplasmic 3 0 39849300.0 5749900.0 3067400.0 31032000.0 False True 5567372.5718361335 4292228.816279687 22903788.259955104 1.0 0.7709613037203471 4.113931296033486 22.408565201756375 -6.8904830525841145 1.0194815079062405 0.8224535636768344 4.404236138792825 0.9812070393720733 0.20902760011622615 0.1187536677813237 0.21954623657428 0.15611979189076122 0.38990685965827837 1.2868174673570293e-07 6.8904830525841145 3.581782575115991 up FTYTPGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FTYTPGTR 8 0 Q12968-5 Q12968-5 NFATC3 Nuclear factor of activated T-cells, cytoplasmic 3 0 26782500.0 6201900.0 14939000.0 5641600.0 False True 9408735.719623137 12273018.731060266 4526535.287198875 1.0 1.3044280439786715 0.4810992063214401 23.165569445989913 -6.806594891574262 1.4287511561323174 1.1665902351362971 0.4677838054457013 0.8507644599520513 0.13130788119214087 0.21147923749924868 0.8514460990615309 0.07227722279783025 0.1674683856623509 1.561007926835425e-07 6.806594891574262 -0.6988064296905958 down FTYTPGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FTYTPGTR 8 0 Q12968-5 Q12968-5 NFATC3 Nuclear factor of activated T-cells, cytoplasmic 3 0 26457600.0 14100000.0 4609900.0 7747700.0 False True 19313151.03817267 4406219.375099272 5917852.828890209 1.0 0.22814606308366395 0.30641570695499165 24.20308023068937 -10.390743789279412 5.907378234164377 1.000184429608031 0.26728088511768516 0.9915146049575917 0.03195344830568715 7.763391104516094e-05 8.006723002052524e-06 0.030946384245074884 0.01031293109515183 4.066831799248492e-11 10.390743789279412 -0.7329035444903458 FTYTPGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FTYTPGTR 8 0 Q12968-5 Q12968-5 NFATC3 Nuclear factor of activated T-cells, cytoplasmic 3 0 13217900.0 5749900.0 3205900.0 4262100.0 False True 4781296.613759845 3188629.1803786755 5153285.404276165 1.0 0.6668963333507245 1.0778008185992465 22.18897047719065 -6.69106008811354 1.8625558524643155 0.7913711762925287 1.0764016728390937 0.37538803168590684 0.14084961532414708 0.41441993270616356 2.788186113405091 0.06047642458511431 0.15728010792995 2.0367602561457115e-07 6.69106008811354 0.285030496546565 FTYTPGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FTYTPGTR 8 0 Q12968-5 Q12968-5 NFATC3 Nuclear factor of activated T-cells, cytoplasmic 3 0 12080400.0 6201900.0 3793900.0 2084600.0 False True 8028481.807725766 3582766.1298938687 1705224.1898022674 1.0 0.44625699051172935 0.21239684296990485 22.936695768082362 -10.438705076943126 0.1904661998917144 1.781102355417461 1.0611636058881938e-10 0.9994513517452882 0.007735740388683091 2.14912386507762 0.0964340409236483 0.9506148626869994 0.151086762586052 3.641622494575632e-11 10.438705076943126 -1.7811023553113445 FVADGIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVADGIFK 8 0 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 0 16868900.0 3421700.0 7104000.0 6343200.0 False True 4485881.8357899375 6044110.891175112 5686866.512270904 1.0 1.3473629293917366 1.2677254373708844 22.09696018770531 -10.067231481266434 4.2967596071286325 0.9999724536957129 1.3075441834059738 0.9521180115388849 0.03251187017508723 11278823.459543504 0.33338574446836583 3370.1023978770368 0.011129677895926149 8.565811612233907e-11 10.067231481266434 0.3075717297102609 FVADGIFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVADGIFK 8 0 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 0 12933500.0 4195700.0 1255800.0 7482000.0 False True 4062509.800110061 1757247.488910486 5522239.744811294 1.0 0.4325521845788234 1.3593172734405923 21.95393986261186 -6.741007062551818 1.6828612930122806 0.6627639397044368 1.3599951960728482 0.6094888985949226 0.2384135832910549 0.31601209678290615 1.75760176969952 0.11205502594888529 0.27468531759843656 1.8154861388677645e-07 6.741007062551818 0.6972312563684114 FVADGIFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVADGIFK 8 0 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 0 16241900.0 3421700.0 5803000.0 7017200.0 False True 4686794.957965632 5546604.272045188 5359881.883770459 1.0 1.1834535800671697 1.1436134782599898 22.1601702492282 -10.142065929321966 4.626335160540352 0.9999824403553079 1.1635335291659834 0.9573838064117796 0.016264653462903452 2.946088477002917e-06 5.463132893008586e-07 0.015749873386605454 0.0052493943391148275 7.209980176983637e-11 10.142065929321966 0.16355108881067548 FVADGIFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVADGIFK 8 0 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 0 8162200.0 4195700.0 2176700.0 1789800.0 False True 3488910.451025611 2164973.6850588787 2164038.904899809 1.0 0.6205300237564012 0.6202620947934223 21.734345138046137 FVADGIFK(ub)AELNEFLTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVADGIFKAELNEFLTR 17 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 1 184732600.0 9922600.0 29452000.0 145358000.0 True False 15053309.63922871 24196060.490473673 116627927.5873253 1.0 1.6073581870274616 7.7476601745701545 23.843577378782374 -6.9260182294197215 0.7787829833400136 0.8915672260783465 8.889267506982977 0.9956961352181372 0.1999490162135677 0.09475856782520448 0.08819998052683689 0.1780198494548513 0.5682393543561509 1.1857189768174215e-07 6.9260182294197215 7.99770028090463 up FVADGIFK(ub)AELNEFLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVADGIFKAELNEFLTR 17 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 1 175132600.0 9922600.0 12454000.0 152756000.0 True False 12845001.30368753 11760923.95205415 124955975.4089203 1.0 0.9156031730940998 9.72798464201386 23.614703700874824 -6.904738873870983 0.9308328740175773 0.6797120407660757 10.747386652537884 0.988779788988339 0.4379434091332586 0.10800032525435149 0.158404663999708 0.3494731702477776 0.9329016234528262 1.245263120017195e-07 6.904738873870983 10.067674611771809 up FVCIYHVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVCIYHVR 8 0 Q15269;A0A0B4J2E5 Q15269 PWP2 Periodic tryptophan protein 2 homolog 0 4610020.0 996440.0 993080.0 2620500.0 False True 1306342.4895386857 844916.3349955213 2349355.7976109684 1.0 0.6467801068721958 1.79842255490029 20.31710175348427 -6.824369588337478 1.3527851882571018 0.8104068984100993 1.8260151226471133 0.8941498618678083 0.15672710488297845 0.18786783179514957 0.6743157275321076 0.09101063183822726 0.20956914077815966 1.4984091337090241e-07 6.824369588337478 1.0156082242370141 FVCIYHVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVCIYHVR 8 0 Q15269;A0A0B4J2E5 Q15269 PWP2 Periodic tryptophan protein 2 homolog 0 3349810.0 996440.0 991570.0 1361800.0 False True 1364850.7957784934 947759.1587164978 1040170.8871513731 1.0 0.6944049574121457 0.7621132583639466 20.38031181500716 -10.114652747124197 5.157627746987691 1.0000073767187856 0.7282591078876522 0.9555092216816267 0.027641798115161077 2.3447619761410163e-06 4.024617752666774e-07 0.026764782385077405 0.00892135197973946 7.679753010836114e-11 10.114652747124197 -0.27174826883113334 FVCPVILFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVCPVILFK 9 0 Q8NCE2-3;Q8NCE2-2;Q8NCE2;B4DJ23 Q8NCE2-3 MTMR14 Myotubularin-related protein 14 0 2329470.0 694840.0 615530.0 1019100.0 False True 910941.9688401318 523695.32331714756 913653.3078974775 1.0 0.5748942756298178 1.0029764124939793 19.796999625134593 -10.945096217783034 11.149938889816742 1.0515515464220053 0.7889353440618986 0.2447855782846482 0.17476380055291138 0.10148287880865314 0.0004997145485640522 0.07667651346473983 0.056404774088445 1.134759382296286e-11 10.945096217783034 -0.26261620236010674 FVDFQK(ub)VR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVDFQKVR 8 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 6197300.0 1238000.0 2662400.0 2296900.0 True False 1623029.988809055 2265180.297953918 2059238.821420582 1.0 1.3956490721505765 1.268762028809836 20.630258226207225 -10.082038052028123 6.007921648561363 0.9999989852434601 1.3322055504802182 0.9013748878270508 0.051801418525913474 7.04099263555622e-07 1.0760734220173757e-07 0.05015666102054894 0.016718835938392435 8.278696242266785e-11 10.082038052028123 0.33220656523675807 FVDFQK(ub)VR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVDFQKVR 8 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 9117000.0 2039600.0 2273000.0 4804400.0 True False 1974854.0144205927 3180620.7535384116 3545983.5110894656 1.0 1.6105599352221394 1.795567411665024 20.913314579345187 -11.188573309208287 0.22317750743336906 9.280485744579124e-11 1.9094915709175062 0.9993059962363491 0.00895495565513924 3.3800254699487953 0.12433604559431144 1.7926236673595652 0.09917467118346941 6.477787405409745e-12 11.188573309208287 1.9094915708247013 FVDFQK(ub)VR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVDFQKVR 8 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 31481700.0 6428700.0 3592300.0 21460700.0 True False 9752807.90092412 2951225.9982319963 17218983.23844103 1.0 0.30260269947000135 1.7655411050195564 23.217386209882324 -6.777056654404942 1.547229452310111 0.6036163361589865 1.7761033007312734 0.7569017570483735 0.2945766491542804 0.2551592111589444 1.2062708183244428 0.14998476106804978 0.35479778474509266 1.670872632104297e-07 6.777056654404942 1.172486964572287 FVDFQK(ub)VR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVDFQKVR 8 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 7318300.0 1238000.0 2904000.0 3176300.0 True False 1695722.0556920401 2775691.6777562 2426123.3579519037 1.0 1.6368789144653864 1.4307317344892232 20.693468287730116 -10.253040101284927 5.048351329675363 0.9999095471378598 1.5338053244774585 0.8993989246495991 0.08415923381013607 8.570245803332892e-05 1.2680364716268056e-05 0.08150054533770083 0.02716227591455409 5.5841862986688396e-11 10.253040101284927 0.5338957773395987 FVDFQK(ub)VR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVDFQKVR 8 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 9466200.0 2039600.0 4428300.0 2998300.0 True False 1696017.769600266 4404443.868951274 3625230.6674271408 1.0 2.596932619396645 2.1374956869004804 20.693719854779463 -10.5364912689096 5.751374606639982 0.9970486339491789 2.367214153148448 0.9219210919264428 0.1875643422675219 0.007102598386818504 0.0005724048282672458 0.18172106412866756 0.06053613116203813 2.9074264099857504e-11 10.5364912689096 1.370165519199269 FVDFQK(ub)VR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVDFQKVR 8 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 25959600.0 6428700.0 4032900.0 15498000.0 True False 8322078.878622143 3808465.5697959824 12677523.02290872 1.0 0.45763391880113213 1.5233601132374381 22.988512531974774 -6.7683574720789546 1.580713915615364 0.6882594913372975 1.5289888646339531 0.7242399565095888 0.2284855314907559 0.2690984501861585 1.326719194435666 0.11395086657076883 0.2716641469271838 1.704678673517659e-07 6.7683574720789546 0.8407293732966556 FVDGLMIHSGDPVNYYVDTAVR ddPTM_RPMI8226_Bortezomib_2h_R1 2 FVDGLMIHSGDPVNYYVDTAVR 22 0 P23396;P23396-2;E9PL09;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 0 64490400.0 29388400.0 12470800.0 22631200.0 False True 28455481.32839684 17450455.474362865 16703409.79855297 1.0 0.6132546230011711 0.5870014850841403 24.762203247274353 -13.999999999999998 0.38212724199085946 6.815957737944651 0.5847803694462703 0.9998109251846343 0.002596159162560215 24.305322839670797 0.20180085662501027 116.38906277923398 0.007070474053661078 1.0000000000000041e-14 13.999999999999998 -6.231177368498381 FVDGLMIHSGDPVNYYVDTAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FVDGLMIHSGDPVNYYVDTAVR 22 0 P23396;P23396-2;E9PL09;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 0 52117200.0 29388400.0 11621100.0 11107700.0 False True 24437756.726868257 11558494.827692261 13430268.713797966 1.0 0.4729769166980943 0.5495704398690558 24.54260852270863 -10.672112480131638 6.700188476341171 1.0031056860203436 0.5112736782836836 0.9819121664273374 0.03126917489514935 0.0014565204880072572 7.127773718193727e-05 0.03039875624548402 0.0100920828015467 2.127587939822205e-11 10.672112480131638 -0.4918320077366599 FVEDTK(ub)NEVHER ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVEDTKNEVHER 12 1 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 1 3431120.0 751340.0 1408580.0 1271200.0 True False 985014.0159869096 1198425.3546018363 1139668.4182114347 1.0 1.216658174555115 1.1570073112813253 19.909784727585464 -10.05755984196055 4.32064736032138 0.9999847248044965 1.1868327429138044 0.9289778010331488 0.02435236305660056 8506780.738000073 7752248.594482111 1455.417967678169 0.008912052149637955 8.758710219932264e-11 10.05755984196055 0.18684801810930785 FVEDTK(ub)NEVHER ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVEDTKNEVHER 12 1 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 1 5823240.0 1447160.0 2488200.0 1887880.0 True False 1401220.6979353337 3481751.235791582 1393387.5928140006 1.0 2.484798605188934 0.9944097991609209 20.418252773301965 -6.647060621031426 2.0190064376917087 1.9657444932067318 1.0006899044742792 0.18212854050267413 0.6341951284426094 0.5158533888387734 4.0271749365896135 0.2550427436967087 0.7023772756437423 2.2539245759440317e-07 6.647060621031426 -0.9650545887324526 FVEDTK(ub)NEVHER ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVEDTKNEVHER 12 1 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 1 9481000.0 3215600.0 1394900.0 4870500.0 True False 4878300.291849301 1145969.1965965566 3907843.5401840163 1.0 0.23491157330171947 0.8010666228795446 22.217947137673 -10.15830680986158 7.1562012111976046 1.000000456805193 0.5179890980940858 0.4914707214214097 0.2311318311276308 1.684406959401512e-06 1.980490337191274e-07 0.22379264659629328 0.07459747772797826 6.945334870144726e-11 10.15830680986158 -0.48201135871110723 FVEDTK(ub)NEVHER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVEDTKNEVHER 12 1 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 1 4555630.0 751340.0 810090.0 2994200.0 True False 1029130.7022000453 774297.545190606 2287031.6274846834 1.0 0.7523801821628054 2.2222946245754156 19.972994789108355 -6.86357304536124 1.167631390955415 0.8641645685355795 2.2984609236625837 0.9578327718778766 0.1319478340257168 0.14316170280074855 0.3688864441014098 0.08800521980467435 0.20631747455889604 1.3690741001262532e-07 6.86357304536124 1.434296355127004 up FVEDTK(ub)NEVHER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVEDTKNEVHER 12 1 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 1 11148000.0 3215600.0 2360200.0 5572200.0 True False 4162657.5889522554 2228852.7952174577 4558116.775600212 1.0 0.5354398596542892 1.0950016133196998 21.98907345976545 -6.686281954349235 1.87938580965862 0.7077455715048167 1.0929983016377633 0.3531793374895018 0.19662646033733563 0.42471591256628677 2.9054332304819757 0.08378408991753536 0.21922710732484968 2.0592925372946518e-07 6.686281954349235 0.3852527301329467 FVEK(ub)CSPIGVYTSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVEKCSPIGVYTSGK 15 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 5261900.0 2299600.0 2962300.0 0.0 True False 3014797.8693580762 2520336.3869549586 0.0 1.0 0.835988512719627 0.0 21.5236298475191 -7.197437154037054 0.894706694753628 0.9908997130033645 1.0033127887731955e-19 0.9893704068577986 0.04514704666701578 0.09254053682646975 0.14084454685932807 0.038027620302655184 0.0667611106789886 6.346917394210841e-08 7.197437154037054 -0.9908997130033645 down FVEK(ub)CSPIGVYTSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVEKCSPIGVYTSGK 15 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 7789100.0 2299600.0 2649600.0 2839900.0 True False 3149824.264353321 2532531.9109444995 2169174.109576432 1.0 0.8040232401550963 0.6886651214561577 21.58683990904199 -13.999999999978465 0.05693262634005904 2.2916027070634377 0.12815084547486816 0.999961646676621 0.0007958701356473494 12.495653034342933 0.0598192666503778 2.364591419628261 0.528664553524139 1.0000000000495856e-14 13.999999999978465 -2.1634518615885696 FVEKPQVFVSNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVEKPQVFVSNK 12 1 Q9Y5P6;Q9Y5P6-2 Q9Y5P6 GMPPB Mannose-1-phosphate guanyltransferase beta 0 5455200.0 1977000.0 2018000.0 1460200.0 False True 2707950.3264161227 1928838.0873663938 1115330.833762985 1.0 0.7122871008934434 0.41187270788644276 21.368769844245058 -6.97058113049277 0.24390750198119462 1.1027758667613754 0.012652573360906963 0.9999865664383824 0.0008800669383004748 0.07611458763187495 0.008352629071816605 0.006986729496194024 0.029087618351958517 1.0700864615327912e-07 6.97058113049277 -1.0901232934004685 down FVELPGAEMGK(ub)VTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVELPGAEMGKVTVR 15 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 52897900.0 6512900.0 11242000.0 35143000.0 True False 9880545.456768656 9235777.2658531 28196970.64627593 1.0 0.9347436643314202 2.853786845032895 23.23615925749582 -6.899025662894445 0.9673834477470207 0.9180661947213619 3.0513003740824733 0.9860759919146614 0.10498032698150507 0.11212684633762991 0.1814819961244146 0.08153562832005562 0.21112894421921544 1.2617529741450523e-07 6.899025662894445 2.1332341793611116 up FVELPGAEMGK(ub)VTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVELPGAEMGKVTVR 15 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 47273800.0 6512900.0 6706900.0 34054000.0 True False 8431077.438452272 6333655.119161072 27856521.42354714 1.0 0.7512272500635183 3.3040286519608673 23.00728557958827 -6.882963332074655 1.0630945616705467 0.8388190140646213 3.4955774842218488 0.9759998071664041 0.17804363814319998 0.12503928944771084 0.25667757022711957 0.12864398406125377 0.31358462074470933 1.3092924632287396e-07 6.882963332074655 2.6567584701572273 up FVETPGQK(ub)YK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVETPGQKYK 10 1 P05455;E7ERC4 P05455 SSB Lupus La protein 1 5536300.0 1229300.0 1517700.0 2789300.0 True False 1190276.5443848001 2123725.5247009457 2058698.6527936596 1.0 1.784228660742536 1.7295969264501532 20.182865372152722 -10.424150348169718 4.562713972793821 0.9982151286239341 1.7569127935969258 0.9961080609496915 0.0223033121326349 0.00040576144590319233 5.1210186524500204e-05 0.0216382890685963 0.007198363037534103 3.76573410672118e-11 10.424150348169718 0.7586976649729916 FVETPGQK(ub)YK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVETPGQKYK 10 1 P05455;E7ERC4 P05455 SSB Lupus La protein 1 13773800.0 3467700.0 5145200.0 5160900.0 True False 5260754.422828028 4226998.860368915 4140845.8528971714 1.0 0.8034967080057319 0.7871201580763342 22.326838274550383 -13.999999999986587 0.35202759129919187 3.446991210222574 0.7849179538925046 0.999758550053649 0.001502948208628913 20.862744073166354 0.19113552215513785 38.211830320980916 0.004852472514700816 1.0000000000308852e-14 13.999999999986587 -2.6620732563300695 FVETPGQK(ub)YK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVETPGQKYK 10 1 P05455;E7ERC4 P05455 SSB Lupus La protein 1 6348100.0 1229300.0 3260400.0 1858400.0 True False 1022217.4172237742 3242835.578061274 2246982.847729243 1.0 3.172354064234637 2.1981457269939613 19.963270647587 -10.354384748753168 7.628895837545621 0.9999799892221422 2.685249895614296 0.799595794578618 0.39771888823414847 0.0001353870653285338 1.1457436952287972e-05 0.38509418318093935 0.12836321921691551 4.4219644954415846e-11 10.354384748753168 1.6852699063921537 FVETPGQK(ub)YK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVETPGQKYK 10 1 P05455;E7ERC4 P05455 SSB Lupus La protein 1 12972200.0 3467700.0 2463500.0 7041000.0 True False 4489006.00858618 2326404.0594094605 5759610.246760896 1.0 0.5182448085299323 1.2830480145814942 22.097964596642832 -6.736452108623189 1.6997502138674063 0.7121843200206398 1.2831526294827282 0.5888807113641774 0.20243701404523926 0.324274810151793 1.8381527523049304 0.09427414480381206 0.23224162160793177 1.8346274676182091e-07 6.736452108623189 0.5709683094620884 FVFDRPLPVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVFDRPLPVSR 11 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 12808400.0 4353100.0 8455300.0 0.0 False True 5706956.255480368 7193802.198501256 0.0 1.0 1.2605322130501835 0.0 22.44429007394649 -6.894863473980913 1.3089251512744575 1.1356766106759844 3.3135657818625234e-19 0.9430116933171961 0.12970375941764398 0.13800889548310957 0.4748162282870715 0.08078554244916836 0.1619151567907363 1.2739034859138072e-07 6.894863473980913 -1.1356766106759844 down FVFDRPLPVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVFDRPLPVSR 11 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 20912600.0 8352000.0 4870600.0 7690000.0 False True 8086870.331653654 6815455.979843452 5675758.304945052 1.0 0.8427804206488104 0.701848560960472 22.947150048173874 -6.972421727771617 0.19172659388299926 1.0933874296579 0.44738463197510037 0.9999956217278518 0.0002547516843559573 0.07552454840939808 0.006128962256535741 0.004902984092438544 0.015290371154605117 1.0655608907677292e-07 6.972421727771617 -0.6460027976827997 FVFDRPLPVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVFDRPLPVSR 11 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 17616700.0 4353100.0 7172800.0 6090800.0 False True 5962558.708104215 6855881.978722329 4652278.483963559 1.0 1.1498221341458532 0.7802486670093925 22.50750013546938 -6.796636455285827 1.469476115225145 1.0830180096981328 0.7755527526640417 0.8221978048981468 0.06399850948641198 0.2255848781374838 0.9619837349433675 0.0342671864506207 0.07986624878703934 1.59721560521593e-07 6.796636455285827 -0.3074652570340911 FVFDRPLPVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVFDRPLPVSR 11 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 25803600.0 5257900.0 14035000.0 6510700.0 False True 6806455.198703834 13253939.912243458 5325819.405423396 1.0 1.9472602882580392 0.7824659459211017 22.698472207690347 -6.690511543780139 1.8655599234979945 1.5936175243136759 0.7865691338946157 0.37244980962296204 0.40058631201584527 0.4155329953246365 2.804543181067687 0.17179174493597113 0.44691089810212287 2.0393344522852303e-07 6.690511543780139 -0.8070483904190602 FVFFNIPQIQYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVFFNIPQIQYK 12 0 E7EPW2;P82663-3;P82663-2;P82663 E7EPW2 MRPS25 28S ribosomal protein S25, mitochondrial 0 27619700.0 8484500.0 6872200.0 12263000.0 False True 12871606.800035885 5645802.2172563225 9839212.674936164 1.0 0.43862450935345404 0.7644121536488151 23.617688824821315 -10.24645363262672 5.861141387133595 1.0000152674514018 0.6015183315011452 0.666081152072999 0.1330022488378413 2.653547284694995e-05 3.411472174675913e-06 0.12878380188818983 0.042926291229756254 5.669520988322457e-11 10.24645363262672 -0.3984969359502566 FVFFNIPQIQYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVFFNIPQIQYK 12 0 E7EPW2;P82663-3;P82663-2;P82663 E7EPW2 MRPS25 28S ribosomal protein S25, mitochondrial 0 50643000.0 22205000.0 11672000.0 16766000.0 False True 18464441.34829083 11609120.619289383 20271693.08277473 1.0 0.6287285057971161 1.0978774120697232 24.138246277892744 -6.695774392370691 1.845847578637359 0.7685089389518245 1.0963808725331865 0.39759981740782613 0.15684247106140017 0.4043743519571044 2.675485450429971 0.06786385249619471 0.17544998653014093 2.0147706126335552e-07 6.695774392370691 0.327871933581362 FVFFNIPQIQYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVFFNIPQIQYK 12 0 E7EPW2;P82663-3;P82663-2;P82663 E7EPW2 MRPS25 28S ribosomal protein S25, mitochondrial 0 23840100.0 8484500.0 10556000.0 4799600.0 False True 10983352.50449851 9968549.320530232 3926122.0480547603 1.0 0.9076053342044117 0.3574611710264892 23.388815146913764 -6.9359973669605 0.6958074214431592 1.0068055264257247 0.22508610137894272 0.9975911602223129 0.013920902773601357 0.08964115769531417 0.0632871712873439 0.013170480126558656 0.04824350694841547 1.1587843816088839e-07 6.9359973669605 -0.781719425046782 down FVFLLCTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVFLLCTR 8 0 Q9HCK8;Q9HCK8-2;A0A2R8Y840;H0YJG4;Q9P2D1;Q3L8U1;Q3L8U1-3;Q3L8U1-2;H3BTW3;Q8TD26 Q9HCK8 CHD8;CHD7;CHD9;CHD6 Chromodomain-helicase-DNA-binding protein 8;Chromodomain-helicase-DNA-binding protein 7;Chromodomain-helicase-DNA-binding protein 9;Chromodomain-helicase-DNA-binding protein 6 0 13040000.0 3646700.0 3316900.0 6076400.0 False True 5532310.509480918 2724973.279942012 4875396.876619265 1.0 0.49255609844605214 0.8812587197092651 22.399450701574786 -9.811112473113456 6.283841409168301 1.000000010589906 0.6869074090775118 0.46382602246825566 0.15868718063006101 2.3569520002679914e-08 4.372236530644428e-09 0.15364820653804348 0.051216067319657964 1.544854303036877e-10 9.811112473113456 -0.31309260151239426 FVFMLSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVFMLSTR 8 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 7009900.0 1524400.0 3350000.0 2135500.0 False True 1998503.1623105993 2850193.058197721 1914538.9451624611 1.0 1.4261638970350328 0.9579864476916505 20.930488424917765 -6.667147507370862 1.9477797642317187 1.2726836479273795 0.959910983035665 0.2664112594141682 0.1811449699670373 0.46765928051634553 3.417832427518507 0.07494983283132617 0.20097339775388906 2.1520506702848985e-07 6.667147507370862 -0.3127726648917145 FVFMLSTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVFMLSTR 8 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 5085200.0 2462900.0 1485200.0 1137100.0 False True 2384716.587623301 2078248.10521568 839259.397731212 1.0 0.8714864131032615 0.351932553363773 21.185386388206524 -6.944630155428245 0.6149807394379625 1.0057113184165125 0.1904186202919509 0.9987096240153439 0.010064112591552493 0.08571636211371504 0.04545742198935865 0.010182269526044289 0.04388829184743618 1.1359778009744817e-07 6.944630155428245 -0.8152926981245616 down FVFMLSTR ddPTM_RPMI8226_Bortezomib_8h_R1 2 FVFMLSTR 8 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 95518400.0 29196800.0 20826900.0 45494700.0 False True 44293680.171994574 17110176.973687593 36502652.60396465 1.0 0.3862893511500494 0.8241052100936979 25.40059753376066 -10.310886352078565 5.92508028571638 1.0000326081714255 0.6051972806219326 0.5202034050909005 0.17873757595171552 7.699709695417511e-05 8.954769986770029e-06 0.17307617423204824 0.057687304583539295 4.887802485841527e-11 10.310886352078565 -0.3948353275494929 FVFMLSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVFMLSTR 8 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 9775900.0 1524400.0 3245900.0 5005600.0 False True 2088011.8753610216 3102485.4052440934 3823380.3735680105 1.0 1.4858562069756749 1.831110454248226 20.993698486440657 -7.177723835558797 0.09241950661337794 2.488422286377957e-11 3.2556882517689756 0.9999996500518628 0.00020158985293484193 0.08910322978888635 0.0038024334362676787 0.050823607312889915 0.08098051626617195 6.641652736173757e-08 7.177723835558797 3.2556882517440915 FVFMLSTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVFMLSTR 8 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 7831200.0 2462900.0 2250800.0 3117500.0 False True 2048010.4749698474 2238674.493651183 3769354.8363086097 1.0 1.0930971892046317 1.8404958775243108 20.9657916636408 -6.9300298805528815 0.746543227019432 0.9886474786353421 1.9940517801056443 0.9965442430825773 0.02211489010118722 0.09262195714424613 0.07760292589786286 0.02015144211385913 0.06761535624091028 1.174816721812929e-07 6.9300298805528815 1.0054043014703022 FVFMLSTR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FVFMLSTR 8 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 93997300.0 29196800.0 30785200.0 34015300.0 False True 37795833.15496992 29071976.557634313 27824864.426451623 1.0 0.7691846992348024 0.7361886775286715 25.17172385585311 -13.999999999999998 0.2739971907141718 2.820375136206178 0.7256534872518239 0.9995919822699793 0.0023706053267724164 15.082953308148294 0.16574182611448396 15.3307184092929 0.013435705761617203 1.0000000000000041e-14 13.999999999999998 -2.094721648954354 FVFSLVDAMNGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 FVFSLVDAMNGK 12 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 92399900.0 21077500.0 34950100.0 36372300.0 False True 27632806.61480032 29735681.31442276 32608843.30373801 1.0 1.0761006556060841 1.1800771365103568 24.719878765761788 -6.966762186844279 0.326397065476275 0.9867882106283118 1.2727751677370565 0.9999449911886493 0.0005473971419321544 0.07736799245765327 0.012778169237561737 0.0015372755453352328 0.009095889551250486 1.0795376990904293e-07 6.966762186844279 0.28598695710874467 FVFSLVDAMNGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 FVFSLVDAMNGK 12 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 205755300.0 103058000.0 43601300.0 59096000.0 False True 99786480.20109712 61011526.46777575 43616984.75800166 1.0 0.6114207690743355 0.4371031493454973 26.57234102618582 -13.999999999995415 0.10833773052400644 2.880673489868918 0.10953335376545384 0.9997515110537931 0.0037089257454265886 12.022680508724742 0.09960385362051284 4.961511563966023 0.2910837434170606 1.0000000000105569e-14 13.999999999995415 -2.7711401361034644 FVFSLVDAMNGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVFSLVDAMNGK 12 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 22051000.0 5541900.0 9512200.0 6996900.0 False True 8407467.467159975 7814673.590842174 5613959.648149793 1.0 0.9294919809522563 0.6677349237541774 23.00323986055355 -6.946590826899083 0.5951022142477882 1.0029829853558316 0.5809568653608426 0.9989058068023244 0.004728271216747328 0.08488441644440042 0.041856509732822594 0.0048765577292376894 0.021962982059742085 1.1308608601335128e-07 6.946590826899083 -0.42202611999498907 FVFSLVDAMNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FVFSLVDAMNGK 12 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 150815370.0 21077500.0 54922570.0 74815300.0 False True 28870421.348020125 52495909.25274865 57145467.00946991 1.0 1.8183284760528344 1.9793776585594873 24.78308882728468 -10.969401286514762 0.30756082658066936 1.963371942876219e-15 2.0237089271645328 0.9992499454123048 0.011743434240203101 2.81882460998 0.15643895292317891 2.062654934985083 0.05613491520193271 1.0729975083760133e-11 10.969401286514762 2.023708927164531 FVFSLVDAMNGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FVFSLVDAMNGK 12 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 170201400.0 103058000.0 41185400.0 25958000.0 False True 85697293.2435107 40963526.07553816 31385697.78376871 1.0 0.47800256606867875 0.36623907939058914 26.352746301620098 -13.9999999999999 0.21661519217408481 4.104024769246836 0.3044824985356175 0.9994947358219796 0.006208657657888074 12.90975886726761 0.14746862572207686 17.111013816137866 0.06326329144753975 1.0000000000002291e-14 13.9999999999999 -3.7995422707112185 FVFSLVDAMNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVFSLVDAMNGK 12 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 27512800.0 5541900.0 10302000.0 11668900.0 False True 7174098.797180769 9728684.643814187 9545279.933024874 1.0 1.3560845646058433 1.3305197214144746 22.774366182646 -10.271309663013508 5.169629366943421 0.9999413061659079 1.3433021430101848 0.9958581713767015 0.01043680352910716 7.061874070124762e-06 9.954178315630173e-07 0.010107114320925132 0.0033684638546193552 5.3541475703509306e-11 10.271309663013508 0.3433608368442769 FVGGVYGGNIKPTPFLCLTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVGGVYGGNIKPTPFLCLTLK 21 1 Q8NAV1 Q8NAV1 PRPF38A Pre-mRNA-splicing factor 38A 0 609110000.0 161670000.0 135390000.0 312050000.0 False True 245265209.66018033 111228596.69310185 250373180.72362614 1.0 0.45350336008605224 1.0208263172364438 27.869767364334148 -10.945585913131824 12.52806271424111 1.0546991239239727 0.7371648386612488 0.22250610637387347 0.23160862739755075 0.12269838364671141 0.0005329243566980585 0.07776034782994211 0.0747513630623894 1.1334805881921838e-11 10.945585913131824 -0.31753428526272387 FVGGVYGGNIKPTPFLCLTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVGGVYGGNIKPTPFLCLTLK 21 1 Q8NAV1 Q8NAV1 PRPF38A Pre-mRNA-splicing factor 38A 0 402564000.0 161670000.0 93474000.0 147420000.0 False True 209285001.99213538 88272089.7297502 120591072.65693672 1.0 0.42177933865068523 0.5762050386270314 27.640893686426597 -10.5040720801249 9.444414926607376 1.0000103775646625 0.4989921886390248 0.9334851174871536 0.06304402801902874 1.3776077025094619e-05 7.234197709841465e-07 0.06104337888772263 0.020347372549627676 3.132765734090598e-11 10.5040720801249 -0.5010181889256378 FVGHTK(ub)DVLSVAFSSDNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVGHTKDVLSVAFSSDNR 18 1 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RFZ9;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 61519200.0 18492700.0 40497000.0 2529500.0 True False 24244108.783561546 34455005.456069596 2267771.6046773316 1.0 1.4211702217501778 0.093539078912852 24.53113088527232 -6.8213739264626305 1.365776650289637 1.2266993859543889 0.06365732095066627 0.8875502597516925 0.1857561043837703 0.19169690118218036 0.7022275918421131 0.10686473015629139 0.246237687257983 1.50878053849174e-07 6.8213739264626305 -1.1630420650037225 down FVGHTK(ub)DVLSVAFSSDNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVGHTKDVLSVAFSSDNR 18 1 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RFZ9;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 98340000.0 43237000.0 44804000.0 10299000.0 True False 41864465.10173728 62694470.849773414 7601382.936622775 1.0 1.4975581485972869 0.18157124229702232 25.31922285627801 -6.804240824194992 1.438374446682267 1.2730592518495396 0.1614037476759358 0.8443409307400762 0.21405444839503926 0.21474134526270658 0.8766021133966218 0.11704748715087789 0.27155703980254325 1.569492250966865e-07 6.804240824194992 -1.1116555041736038 down FVGHTK(ub)DVLSVAFSSDNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVGHTKDVLSVAFSSDNR 18 1 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RFZ9;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 148212000.0 89284000.0 11186000.0 47742000.0 True False 135450355.53472856 9189770.903383099 38305772.77393807 1.0 0.06784604490039085 0.2828030433933909 27.01318893947911 -10.732933564846775 10.007333508889328 1.001752508703935 0.17532454414690074 0.9515143047824798 0.08775582715801045 0.0034329742210787227 9.161582299488987e-05 0.08501107219434569 0.028323071426302582 1.849551528032855e-11 10.732933564846775 -0.8264279645570343 FVGHTK(ub)DVLSVAFSSDNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVGHTKDVLSVAFSSDNR 18 1 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RFZ9;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 49906400.0 18492700.0 26112400.0 5301300.0 True False 25329950.93642664 24958667.825840525 4049242.1237006686 1.0 0.985342130684818 0.15985984867730285 24.59434094679521 -6.910752031980876 0.8906085204894553 1.0249550734186992 0.05145010889694226 0.9912019384774121 0.03682851820711548 0.10392286028724154 0.13608964516411146 0.030264486833839383 0.08398429468576421 1.2281402591369334e-07 6.910752031980876 -0.9735049645217569 down FVGHTK(ub)DVLSVAFSSDNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVGHTKDVLSVAFSSDNR 18 1 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RFZ9;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 92240300.0 43237000.0 41522000.0 7481300.0 True False 35953481.22387079 41298312.744528264 9045605.240377108 1.0 1.148659638474976 0.2515919163447074 25.099628131712286 -6.864329220215865 1.163600642402051 1.0817936166227593 0.2044044809597142 0.9586924809804552 0.07978530240077182 0.14241212804603331 0.363961189830514 0.053375341624681986 0.1252719021763222 1.3666924013019808e-07 6.864329220215865 -0.8773891356630451 down FVGHTK(ub)DVLSVAFSSDNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVGHTKDVLSVAFSSDNR 18 1 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RFZ9;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 138983600.0 89284000.0 22306000.0 27393600.0 True False 115579898.05075671 21064651.49145012 22408245.882072024 1.0 0.18225186080541111 0.1938766711165594 26.78431526157156 -10.303885589921052 5.559598645657314 1.0001094976816236 0.1880642659609848 0.99984628240494 0.004745808936544476 6.4419560134377245e-06 8.06599036310352e-07 0.00459572026863275 0.001531703247952447 4.9672316043952637e-11 10.303885589921052 -0.8120452317206388 FVGNIYTLK(ub)CR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVGNIYTLKCR 11 1 B9EGQ5;A0A669KBG4;M0QXA7;A0A669KBH9;A0A2R8YFV2;A0A669KAV7;O95785-2;O95785-4;O95785-3;O95785 B9EGQ5 WIZ Protein Wiz 1 135467700.0 35718400.0 82129300.0 17620000.0 True False 46827168.297477685 69875928.57750396 15796851.422974722 1.0 1.4922091409329952 0.3373437258179374 25.480842463155945 -6.790883651401454 1.4927535788874344 1.2747696061489342 0.32474857279000074 0.8042244413938758 0.209365921011919 0.23401533839869615 1.0301327414588652 0.11039130056147077 0.25829293289150723 1.6185135834804193e-07 6.790883651401454 -0.9500210333589334 down FVGNIYTLK(ub)CR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVGNIYTLKCR 11 1 B9EGQ5;A0A669KBG4;M0QXA7;A0A669KBH9;A0A2R8YFV2;A0A669KAV7;O95785-2;O95785-4;O95785-3;O95785 B9EGQ5 WIZ Protein Wiz 1 115469800.0 35718400.0 44835400.0 34916000.0 True False 48924457.73346575 42854423.77715919 26669559.91759237 1.0 0.8759304806325021 0.5451171285920992 25.544052524678836 -6.954067103211276 0.5122554351753391 1.0059771838205316 0.40050131373348646 0.9994829944441467 0.004365468689395292 0.08189260922945793 0.029513359350992165 0.005008809614714809 0.02730712092119114 1.1115599659328541e-07 6.954067103211276 -0.6054758700870451 FVGNIYTLK(ub)CR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVGNIYTLKCR 11 1 B9EGQ5;A0A669KBG4;M0QXA7;A0A669KBH9;A0A2R8YFV2;A0A669KAV7;O95785-2;O95785-4;O95785-3;O95785 B9EGQ5 WIZ Protein Wiz 1 67868000.0 40508000.0 10547000.0 16813000.0 True False 33684196.80867208 10490181.217584414 20328520.565471247 1.0 0.31142738172351764 0.6035032000596083 25.005568563241027 -10.447572827148207 6.107896179191436 1.000229223800827 0.4574652908919228 0.8214436870315843 0.11923945352154308 0.0003723505986265881 3.367728884440538e-05 0.11550067427442517 0.03848436814165076 3.568019119020879e-11 10.447572827148207 -0.5427639329089042 FVGSFK(ub)TK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVGSFKTK 8 1 Q9NX01 Q9NX01 TXNL4B Thioredoxin-like protein 4B 1 1756130.0 579190.0 698450.0 478490.0 True False 481622.1474675327 694687.3112185291 578540.0467122077 1.0 1.4423907099607782 1.2012322310223669 18.87754221061023 -10.070027495444469 4.288876558862414 0.9999681769626291 1.3218114703102661 0.7036427689660568 0.09845253693395699 68868251.96750988 89207798.29670796 28513.038696075193 0.036029925554754115 8.51084153847762e-11 10.070027495444469 0.32184329334763706 FVHTSVHGVGHSFVQSAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVHTSVHGVGHSFVQSAFK 19 0 Q96G03;Q96G03-2 Q96G03 PGM2 Phosphoglucomutase-2 0 23246900.0 8980900.0 4981700.0 9284300.0 False True 8695806.245396124 6970918.7892223075 6852463.30697026 1.0 0.801641457100423 0.7880193180015025 23.05188836480436 -13.999999999999998 0.3804195772236283 3.9508219786991767 0.7868313083680759 0.9998081917522252 0.0013416929649851077 24.087823837294756 0.2011828018020595 58.22104551425316 0.003687490617597593 1.0000000000000041e-14 13.999999999999998 -3.163990670331101 FVHTSVHGVGHSFVQSAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVHTSVHGVGHSFVQSAFK 19 0 Q96G03;Q96G03-2 Q96G03 PGM2 Phosphoglucomutase-2 0 29124800.0 7652400.0 6960400.0 14512000.0 False True 10481699.078334209 6652866.513035205 11084564.484021664 1.0 0.6347126036833814 1.0575160001429142 23.3213692602093 -6.678190863440657 1.908572837714455 0.768498641689895 1.0558741806669454 0.3157320956957397 0.15488003000704595 0.4425653695109703 3.115340537452722 0.06515685237869415 0.17222990416351874 2.098017645632012e-07 6.678190863440657 0.28737553897705037 FVHTSVHGVGHSFVQSAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVHTSVHGVGHSFVQSAFK 19 0 Q96G03;Q96G03-2 Q96G03 PGM2 Phosphoglucomutase-2 0 20539000.0 8980900.0 6370300.0 5187800.0 False True 7468016.27132921 6335981.929494458 6272544.994322948 1.0 0.8484156567546867 0.8399211740344155 22.832293640238635 FVIATSTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVIATSTK 8 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 127036000.0 41035000.0 42755000.0 43246000.0 False True 53797282.38350528 36376120.65768469 38771318.76492429 1.0 0.6761702273057185 0.7206928872082192 25.681029959839776 -10.511712610262691 6.871405523077856 1.0001330960683639 0.6984315572569688 0.9839154284908704 0.018176299792099896 3.707727504132988e-05 2.6347455995244268e-06 0.01760681559172099 0.005866375532539686 3.078133062628895e-11 10.511712610262691 -0.30170153881139505 FVIATSTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVIATSTK 8 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 58881200.0 15966000.0 7705200.0 35210000.0 False True 15459168.06934656 10781926.54208717 25987444.722641755 1.0 0.6974454572019482 1.6810377250617607 23.88195934734737 -6.824142644444716 1.3540536378450685 0.8375765134249403 1.7044431158893811 0.8936044718802582 0.1341722287692825 0.1881556776350141 0.6767286806742276 0.07784706284877549 0.17923999917503375 1.4991923434446306e-07 6.824142644444716 0.8668666024644408 FVIATSTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVIATSTK 8 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 97610000.0 41035000.0 22901000.0 33674000.0 False True 56206748.42917838 21889158.09652019 25720894.73779945 1.0 0.38944003537406124 0.45761221662214263 25.744240021362668 -10.313541717567116 5.698502367313685 1.0000706310206682 0.42352612600061396 0.9896202953516432 0.027831176451737254 2.49771069025861e-05 3.0088365962519983e-06 0.026950698962065048 0.008982473575242634 4.858008635162305e-11 10.313541717567116 -0.5765445050200542 FVIATSTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVIATSTK 8 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 37771200.0 15966000.0 13803000.0 8002200.0 False True 13276436.413727151 13728640.499319026 9675423.022007631 1.0 1.0340606523844245 0.7287665696198222 23.662364622781645 -6.879197815680444 1.0842105411675849 1.020896875719469 0.7074561324682374 0.9730348913491501 0.02243090416401084 0.12834553002208693 0.27657085036088175 0.015947713341381196 0.038489969770315456 1.3206939376677116e-07 6.879197815680444 -0.3134407432512316 FVIATSTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVIATSTK 8 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 52320000.0 15512000.0 24353000.0 12455000.0 False True 20080589.78723329 22997734.141992535 10188317.79909203 1.0 1.145271846378431 0.5073714421261418 24.259298307535126 -6.846833063630231 1.2502628886128984 1.0773609084740021 0.483384849404176 0.9355716102428653 0.06929194367154712 0.16097454804606276 0.48581347718685775 0.0434006351989311 0.10025014687638249 1.422875614342569e-07 6.846833063630231 -0.5939760590698262 FVIFPIEYHDIWQMYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVIFPIEYHDIWQMYK 16 0 P31350;P31350-2;A0A286YFD6;C9JXC1 P31350 RRM2 Ribonucleoside-diphosphate reductase subunit M2 0 10689300.0 4177400.0 2090400.0 4421500.0 False True 4044790.723593148 2925107.6212919904 3263376.5078432458 1.0 0.723178977896167 0.8068097290690627 21.947633629248923 -10.248829012709471 7.708657059996451 1.0000003806788624 0.7649943534826149 0.9132578667654434 0.034142111196543354 2.2335514414849885e-07 2.1790800588126556e-08 0.03305801070930348 0.01101931900571451 5.638596108682741e-11 10.248829012709471 -0.23500602719624752 FVIFPIEYHDIWQMYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVIFPIEYHDIWQMYK 16 0 P31350;P31350-2;A0A286YFD6;C9JXC1 P31350 RRM2 Ribonucleoside-diphosphate reductase subunit M2 0 47648000.0 12180000.0 14349000.0 21119000.0 False True 18477950.477274697 11788308.840751283 16944820.393213492 1.0 0.6379662536301988 0.9170292134970953 24.13930141012958 -9.801031415543477 5.888995540778086 1.000000019347007 0.7774977335630135 0.4587643237199964 0.11392697629969514 2.8930085380958963e-08 5.861522943996039e-09 0.11030933033455011 0.03676977349071182 1.5811336607278463e-10 9.801031415543477 -0.22250228578399356 FVIFPIEYHDIWQMYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVIFPIEYHDIWQMYK 16 0 P31350;P31350-2;A0A286YFD6;C9JXC1 P31350 RRM2 Ribonucleoside-diphosphate reductase subunit M2 0 9396300.0 4177400.0 2160800.0 3058100.0 False True 3473693.1901981523 2149159.341514782 3697534.570943183 1.0 0.6186957868297477 1.0644390187874542 21.7280389046832 -6.680190052805798 1.9010127937672663 0.7587892476239595 1.062753331336695 0.3250871666980816 0.16159842578266323 0.4380982218721684 3.0611137067928635 0.0682028497939865 0.17984977873247338 2.08838202823903e-07 6.680190052805798 0.30396408371273553 FVIHCNSPVWGADK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVIHCNSPVWGADK 14 0 O75367-2;O75367-3;O75367;B4DJC3 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 0 5724000.0 2453700.0 3270300.0 0.0 False True 3216824.461664604 2782383.987529556 0.0 1.0 0.86494741030717 0.0 21.617205781287606 -7.1587315986389966 0.9294642035779233 0.9934192049251201 2.781638691630918e-18 0.9896493807182826 0.04507161765229302 0.08863272924405809 0.14500490318940779 0.037755655583465046 0.06629596578565002 6.93854487386592e-08 7.1587315986389966 -0.9934192049251201 down FVIHCNSPVWGADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVIHCNSPVWGADK 14 0 O75367-2;O75367-3;O75367;B4DJC3 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 0 10048900.0 2453700.0 2766000.0 4829200.0 False True 3360899.1987492414 2643788.9740611687 3688642.420495965 1.0 0.786631439302034 1.0975165282757344 21.680415842810497 -6.7219571062225185 1.7519701924044067 0.8704656279746533 1.0970968520874238 0.5219049787148806 0.08976507426850426 0.3515130466184177 2.109559495765576 0.04066360378755456 0.10185830595658686 1.8968932616055675e-07 6.7219571062225185 0.22663122411277048 FVINYDYPNSSEDYIHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVINYDYPNSSEDYIHR 17 0 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 29370100.0 7089100.0 11281000.0 11000000.0 False True 9293878.750942064 9597918.772993587 9861825.519450739 1.0 1.0327140078108619 1.0611097673779213 23.147849392722883 -6.972780834708545 0.17974132640829196 0.9779731800833569 1.1166182790737016 0.9999966838136366 4.510098260372086e-05 0.07541026414195898 0.00566679694528933 0.001095991239666698 0.0031891412998773386 1.0646801700464701e-07 6.972780834708545 0.13864509899034472 FVINYDYPNSSEDYIHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVINYDYPNSSEDYIHR 17 0 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 33148500.0 12012000.0 4808500.0 16328000.0 False True 11630685.635036366 6728559.1259962395 12051206.97049973 1.0 0.5785178395439626 1.036156194798747 23.47143281116114 -6.6645973922501796 1.9561558969899315 0.7297249996405822 1.0342799852078275 0.2553332761103593 0.17926365828091373 0.473750456489452 3.4894151617586115 0.07390757915923145 0.19889083946941535 2.1647243768940756e-07 6.6645973922501796 0.30455498556724525 FVINYDYPNSSEDYIHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVINYDYPNSSEDYIHR 17 0 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 32874100.0 7089100.0 12098000.0 13687000.0 False True 9710131.845724108 11563470.357263941 10454412.492613327 1.0 1.1908664620610645 1.0766499012283717 23.211059454245774 -10.69576337000329 5.867938468067446 0.9978067985132305 1.1337581816447182 0.646469569352373 0.04662871570260866 0.001358647073689065 7.044200156338716e-05 0.04584863608781901 0.01504935328093696 2.0148217480374392e-11 10.69576337000329 0.1359513831314877 FVINYDYPNSSEDYIHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVINYDYPNSSEDYIHR 17 0 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 22671400.0 12012000.0 5235000.0 5424400.0 False True 9988510.221827026 5206798.015933857 6558616.96040815 1.0 0.5212787393014718 0.6566161334125856 23.251838086595416 -10.503704110604486 9.327710225411144 1.0000096514623045 0.5889474363570391 0.9248108649067239 0.05525125978169629 1.1089759293138965e-05 5.900998370848991e-07 0.053498055894161234 0.017832267415957438 3.1354211921901706e-11 10.503704110604486 -0.4110622151052654 FVINYDYPNSSEDYIHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVINYDYPNSSEDYIHR 17 0 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 17565800.0 6013200.0 6389900.0 5162700.0 False True 7784205.937892675 6034296.44782646 4223141.573775387 1.0 0.7751974313079457 0.5425269587508713 22.892118447691704 -6.970693473713511 0.24104870389345046 1.082466371977489 0.22851963148434895 0.9999872965262178 0.0006656657372908019 0.07607834084706293 0.008220851527791256 0.005520659052249548 0.022640861123699917 1.0698096875532485e-07 6.970693473713511 -0.85394674049314 FVINYDYPNSSEDYVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVINYDYPNSSEDYVHR 17 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 29254000.0 7300000.0 10345000.0 11609000.0 False True 9570370.693300555 8801566.324494168 10407812.041391237 1.0 0.919668276867837 1.0875035434810176 23.1901433756477 -6.776554209926098 1.5493326237179266 0.9543107246804841 1.0886914269641512 0.7550019215757077 0.03392509398064659 0.2559619695389566 1.2133379239075557 0.01725076641767718 0.04082276283859212 1.6728068186547554e-07 6.776554209926098 0.13438070228366716 FVINYDYPNSSEDYVHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVINYDYPNSSEDYVHR 17 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 25763600.0 9096900.0 3321700.0 13345000.0 False True 8808123.888891298 4648072.132436658 9849544.158581512 1.0 0.5277028560303009 1.1182340624209022 23.07040333030549 -6.693720256602988 1.853239873986555 0.704938010536666 1.1162873604979386 0.3878804415552314 0.19960012261001928 0.4087168475890734 2.7244081800160926 0.08607085608315256 0.22308557200738063 2.0243226918148112e-07 6.693720256602988 0.4113493499612726 FVINYDYPNSSEDYVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVINYDYPNSSEDYVHR 17 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 40126000.0 7300000.0 13658000.0 19168000.0 False True 9999007.275082292 13054544.399033796 14640913.177351693 1.0 1.305584048485089 1.4642366761585537 23.253353437170592 -11.815178394596385 0.10442376237674876 2.3968075236606823e-21 1.8226973972869978 0.999841619644006 0.002424630607204715 5.169901206988453 0.07402313599811224 1.4232625615753178 0.2629922579718705 1.5304586679703978e-12 11.815178394596385 1.8226973972869978 FVINYDYPNSSEDYVHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVINYDYPNSSEDYVHR 17 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 18454600.0 9096900.0 4869200.0 4488500.0 False True 7564475.41100052 4842968.6531394785 5427024.597520837 1.0 0.6402253150425563 0.7174356849159257 22.850808605739765 -9.968392919116177 5.381070769232525 1.0000009027834442 0.6788304999782849 0.9584552826986289 0.03152100151023985 3.4137347555275485e-07 6.545772615095124e-08 0.030520164197895657 0.01017335949159311 1.0754917440102522e-10 9.968392919116177 -0.3211704028051593 FVK(ub)QDQVCIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVKQDQVCIAR 11 1 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 1 7833100.0 1926500.0 3502000.0 2404600.0 True False 2525660.156252536 2979515.2506890832 2155795.0585519313 1.0 1.179697610271509 0.8535570604045976 21.268229097652508 -6.757128605432083 1.6233317573980353 1.1047504295078325 0.8525338526437207 0.679117901742822 0.07555325075548311 0.287767270427446 1.4939128478423815 0.036734451101213775 0.08852893093455769 1.749328592074538e-07 6.757128605432083 -0.2522165768641118 FVK(ub)QDQVCIAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVKQDQVCIAR 11 1 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 1 19022600.0 4508000.0 2589600.0 11925000.0 True False 6838965.578945343 2127465.6473628534 9568018.523086837 1.0 0.3110800343713582 1.399044696546396 22.705346697508105 -6.735602149933868 1.702953122434227 0.5880189706722644 1.399072521823317 0.5849869500667098 0.2894999968725549 0.3258248606393822 1.8535722515403044 0.13458776313894047 0.33185426413093644 1.838221536918677e-07 6.735602149933868 0.8110535511510527 FVK(ub)QDQVCIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVKQDQVCIAR 11 1 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 1 6568600.0 1926500.0 1990800.0 2651300.0 True False 2638779.111704936 1902839.8733047661 2025117.5452375056 1.0 0.7211061603694924 0.7674448900457839 21.3314391591754 -10.309463343996681 5.644089014317751 1.0000323833624865 0.744275525207651 0.9759652658543685 0.01891770717262273 7.709776309987753e-06 9.432458856199725e-07 0.018319307630514432 0.0061056637356649715 4.903844112386218e-11 10.309463343996681 -0.2557568581548355 FVK(ub)QDQVCIAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVKQDQVCIAR 11 1 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 1 10474900.0 4508000.0 2483300.0 3483600.0 True False 5835694.86596491 2345102.1720038624 2849620.5447544768 1.0 0.4018548306356845 0.48830869505773977 22.476473019600554 -10.728280461998585 6.917354116665407 1.0073223196702084 0.44508176284731765 0.9821212477068525 0.03529464235429866 0.003984007047284937 0.0001564950632553638 0.0341597856771903 0.011391296837378799 1.8694744669962598e-11 10.728280461998585 -0.5622405568228908 FVLDKVPFLSSLEGHIYLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVLDKVPFLSSLEGHIYLK 19 1 H7C3S1;Q9NQW6-2;Q9NQW6 H7C3S1 ANLN Actin-binding protein anillin 0 19957800.0 3448900.0 7673700.0 8835200.0 False True 5232233.448363927 6304268.280108244 7088918.847394273 1.0 1.204890481727174 1.3548552291012388 22.31899548081831 -6.974533190151064 0.10302287175074978 0.6474315859840187 1.9161245493626031 0.9999997095937102 7.816717641277595e-05 0.07485763165218054 0.0030302348128279873 0.013007432227334342 0.02405736000117317 1.0603928967133414e-07 6.974533190151064 1.2686929633785844 FVLDKVPFLSSLEGHIYLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVLDKVPFLSSLEGHIYLK 19 1 H7C3S1;Q9NQW6-2;Q9NQW6 H7C3S1 ANLN Actin-binding protein anillin 0 10637800.0 3448900.0 3303700.0 3885200.0 False True 4464669.037982779 3119846.190814303 3178133.465518455 1.0 0.698785545865211 0.7118407744181628 22.090121802910758 -9.769199183046947 6.036695364120728 1.0000000109494211 0.7053131601457503 0.9985301587366272 0.0053297747408704394 7.79275214484339e-10 1.6559938572097828e-10 0.005160532355298106 0.0017201774005007932 1.7013780163650466e-10 9.769199183046947 -0.29468685080367085 FVLHAVQLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVLHAVQLVK 10 0 A0A494C1B8;A0A494C0U1;Q5VZU9;P29144 A0A494C1B8 TPP2 Tripeptidyl-peptidase 2 0 5889700.0 2087600.0 2517100.0 1285000.0 False True 2736863.81634716 2141558.491578952 1152040.5265903813 1.0 0.7824863183865864 0.4209345454857114 21.384092218726117 -6.9634948238400804 0.38300763865926746 1.024010400950015 0.16656380242628233 0.999878676205428 0.002630612743494548 0.07847551467136396 0.016684300598415774 0.004691711222978876 0.03050754810171033 1.0876901012411551e-07 6.9634948238400804 -0.8574465985237327 down FVLHAVQLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVLHAVQLVK 10 0 A0A494C1B8;A0A494C0U1;Q5VZU9;P29144 A0A494C1B8 TPP2 Tripeptidyl-peptidase 2 0 7197500.0 2087600.0 2098800.0 3011100.0 False True 2859442.135268743 2006068.076196523 2299940.1955511104 1.0 0.7015592487266694 0.8043317845755084 21.44730228024901 -10.880323868456268 10.58466720965133 1.0133678238514006 0.7529455166510889 0.8851228880039648 0.04195671206692458 0.012614562849165456 0.00014262697238176734 0.03871843737292167 0.013541470591401554 1.3172740352534989e-11 10.880323868456268 -0.2604223072003117 FVLINWTGEGVNDVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVLINWTGEGVNDVR 15 0 Q9UJU6;F8WBG8;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 Q9UJU6;Q9UJU6-2 DBNL Drebrin-like protein 0 6763800.0 2187600.0 2667600.0 1908600.0 False True 2867964.7847485356 2269604.478223356 1711116.380583971 1.0 0.7913641374862125 0.5966308895016653 21.451595878865888 -6.971955820963349 0.2061884080494674 1.1070452374317714 0.27553664971975544 0.9999938853460819 0.00040724455040274315 0.07567305110439725 0.006709081562082421 0.006011789634237479 0.02036088945280929 1.0667046272967661e-07 6.971955820963349 -0.831508587712016 FVLINWTGEGVNDVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVLINWTGEGVNDVR 15 0 Q9UJU6;F8WBG8;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 Q9UJU6;Q9UJU6-2 DBNL Drebrin-like protein 0 19028400.0 9002600.0 3527000.0 6498800.0 False True 8716817.390774095 4935349.493062021 4796569.320179052 1.0 0.5661870923538687 0.5502661241080666 23.055370056086 FVLINWTGEGVNDVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVLINWTGEGVNDVR 15 0 Q9UJU6;F8WBG8;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 Q9UJU6;Q9UJU6-2 DBNL Drebrin-like protein 0 22813000.0 5631000.0 10474000.0 6708000.0 False True 8542638.681242514 8604832.866264472 5382160.859779156 1.0 1.0072804419503918 0.6300349412643458 23.026250332887916 -6.9025001030262985 0.9453197851469789 1.0146267952480625 0.5883620641475171 0.9877698135342199 0.01947982740996331 0.10958857378870453 0.1672195977769136 0.015379225343127582 0.04054049072987837 1.2516989760951233e-07 6.9025001030262985 -0.4262647311005454 FVLINWTGEGVNDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVLINWTGEGVNDVR 15 0 Q9UJU6;F8WBG8;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 Q9UJU6;Q9UJU6-2 DBNL Drebrin-like protein 0 13678000.0 2187600.0 4053200.0 7437200.0 False True 2996414.837667129 3874116.221859996 5680686.533941975 1.0 1.2929171799443515 1.8958277947804771 21.51480594038878 -6.959479476083934 0.44271588417253244 0.9790428383884129 2.2333147638831004 0.9997503840234224 0.005892285507096281 0.07988769396036886 0.02182300453439635 0.007976636589493298 0.049929936895733495 1.097793168626794e-07 6.959479476083934 1.2542719254946875 FVLINWTGEGVNDVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVLINWTGEGVNDVR 15 0 Q9UJU6;F8WBG8;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 Q9UJU6;Q9UJU6-2 DBNL Drebrin-like protein 0 15844700.0 9002600.0 3186800.0 3655300.0 False True 7486060.7828022 3169632.075869729 4419606.329802357 1.0 0.4234045338172187 0.590378098446056 22.835775331520278 -10.820849340759574 10.841802874388831 1.0056315315095434 0.5068913161317287 0.920814854457918 0.06816667231238019 0.009203115357187337 0.00015207256659393136 0.06546215443862954 0.022000698886018886 1.5106041004837203e-11 10.820849340759574 -0.49874021537781477 FVLINWTGEGVNDVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVLINWTGEGVNDVR 15 0 Q9UJU6;F8WBG8;Q9UJU6-2;Q9UJU6-3;Q9UJU6-6 Q9UJU6;Q9UJU6-2 DBNL Drebrin-like protein 0 12051400.0 5631000.0 6420400.0 0.0 False True 7289440.503604355 6063099.096014812 0.0 1.0 0.8317646728876978 0.0 22.797376654980365 -7.203392569004423 0.889687594814593 0.990627420508029 6.257196075339627e-20 0.9893140868908786 0.04519245170716004 0.0931872064196167 0.1403999618488885 0.03809302470097669 0.06688799780454073 6.260477095701097e-08 7.203392569004423 -0.990627420508029 down FVLK(ub)NYGENPEAYNEELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVLKNYGENPEAYNEELK 18 1 Q9H3S7;R4GMM7 Q9H3S7 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 1 18863600.0 5131900.0 7653100.0 6078600.0 True False 6727970.597390294 6511287.311550151 5449644.782048484 1.0 0.9677936633783458 0.8099983053080436 22.68173997005815 -6.940259237440736 0.6571479402205641 1.0017636238618919 0.7671195185607761 0.9981976445082535 0.003524720787219289 0.08764859450211532 0.05407271431748173 0.003437824691387557 0.013565695976988533 1.1474684744317317e-07 6.940259237440736 -0.2346441053011158 FVLK(ub)NYGENPEAYNEELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVLKNYGENPEAYNEELK 18 1 Q9H3S7;R4GMM7 Q9H3S7 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 1 16060300.0 4383500.0 4466400.0 7210400.0 True False 4244348.191906586 6249856.811968303 5321779.932636649 1.0 1.4725127462176544 1.2538509311711474 22.01711158423176 -10.16121366259684 4.647773687592877 0.9999541189207507 1.3631818386983094 0.7862447944292081 0.08926831219583617 4.2445641364410594e-05 7.660249283357404e-06 0.08644456960411322 0.028811223871320027 6.899003057276103e-11 10.16121366259684 0.36322771977755874 FVLK(ub)NYGENPEAYNEELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVLKNYGENPEAYNEELK 18 1 Q9H3S7;R4GMM7 Q9H3S7 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 1 16317300.0 5131900.0 5265700.0 5919700.0 True False 7029302.1143828565 5033043.962658687 4521588.780048449 1.0 0.7160090547766372 0.6432486051206557 22.74495003158104 -13.999999999999998 0.19120421623147835 2.5287489957799463 0.5916773105794536 0.9994887895757845 0.0034800733775563544 12.370548730791917 0.13866760942501855 7.048701260481794 0.04956318062378585 1.0000000000000041e-14 13.999999999999998 -1.9370716852004928 FVLK(ub)NYGENPEAYNEELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVLKNYGENPEAYNEELK 18 1 Q9H3S7;R4GMM7 Q9H3S7 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 1 20866600.0 4383500.0 9347500.0 7135600.0 True False 3645074.4719762555 9297143.162166512 8627620.968713311 1.0 2.550604448179042 2.3669258433657356 21.797516859666036 -10.10772535584134 4.14454051300573 0.9997096240356728 2.4587651459752604 0.988249020759138 0.07498647751363258 2987196.806797046 910660.0517619571 7787.375983946058 0.02566986564741522 7.803234244595041e-11 10.10772535584134 1.4590555219395878 FVLK(ub)NYGENPEAYNEELKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVLKNYGENPEAYNEELKK 19 2 Q9H3S7;R4GMM7 Q9H3S7 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 1 11646900.0 3676700.0 3453400.0 4516800.0 True False 3559985.1710238312 4832360.629243085 3333714.5789045277 1.0 1.3574103253506884 0.9364405801571838 21.76343980103974 -6.681786726607867 1.8957586923724556 1.2257806774321032 0.9380298211995463 0.33217656314194877 0.1514213217838096 0.4345933037229234 3.021333577050483 0.06405857145314528 0.16855086695973293 2.0807182356409165e-07 6.681786726607867 -0.2877508562325569 FVLK(ub)NYGENPEAYNEELKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVLKNYGENPEAYNEELKK 19 2 Q9H3S7;R4GMM7 Q9H3S7 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 1 12434200.0 3676700.0 4554700.0 4202800.0 True False 3057338.955427196 4530162.927062836 5081586.048448384 1.0 1.4817339500486773 1.66209443000354 21.543845076474017 -11.447842666594644 0.1770638907402051 3.541775090277765e-18 1.8345738083707854 0.9994819279694953 0.006361228049074078 4.038863014852751 0.10755272355284083 1.6981396028621332 0.13524758594715042 3.56580289638635e-12 11.447842666594644 1.8345738083707854 FVLLSAQGSLMFHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVLLSAQGSLMFHK 14 0 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 0 17814800.0 6097800.0 0.0 11717000.0 False True 9250808.408893729 0.0 9401129.814256456 1.0 0.0 1.0162495426041045 23.141148014579155 -12.07179526686693 14.613017070045151 0.8832639875424914 0.5573122941718581 0.0 0.4889419856946372 0.0 0.0 0.0 0.14059175850586886 8.476269043975121e-13 12.07179526686693 -0.32595169337063323 FVLLSAQGSLMFHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVLLSAQGSLMFHK 14 0 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 0 21302200.0 6097800.0 7863600.0 7340800.0 False True 7893722.305607994 7425983.74734005 6004849.722968664 1.0 0.9407455012781935 0.7607120557943361 22.912274336671604 -6.951165588155992 0.5459038781628509 1.00255242871332 0.6905067186404525 0.9992895640817899 0.0027121012477567576 0.08302117632995737 0.03405217448868662 0.0029593910655848618 0.014924102167249424 1.1190111446323289e-07 6.951165588155992 -0.3120457100728675 FVLMNK(ub)MDDLNLHYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVLMNKMDDLNLHYR 15 1 Q8NCJ5;F8VWW7;B7Z1Y3 Q8NCJ5 SPRYD3 SPRY domain-containing protein 3 1 14591500.0 3611400.0 2404900.0 8575200.0 True False 3496758.083780412 3365189.1113878204 6329097.86951428 1.0 0.9623740135175866 1.8099902017447462 21.737586558839112 -6.896513859515408 0.9830603302114158 0.961309654007575 1.8929176833767871 0.9847500784802024 0.04828523543080371 0.11401662475375617 0.19225229766316299 0.03706681847893227 0.09485897146629135 1.26907164427907e-07 6.896513859515408 0.9316080293692122 FVLMNK(ub)MDDLNLHYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVLMNKMDDLNLHYR 15 1 Q8NCJ5;F8VWW7;B7Z1Y3 Q8NCJ5 SPRYD3 SPRY domain-containing protein 3 1 13936000.0 3611400.0 8332700.0 1991900.0 True False 3003039.1121466956 8287810.091188543 2408397.0804949887 1.0 2.759807575487778 0.8019865844415751 21.51799183427339 -6.669873381261692 1.9381234655368456 2.123437961841837 0.8099677571806467 0.27831353452903274 0.747557039192923 0.4614368169402547 3.3416233054287954 0.310554393450972 0.8297692489460754 2.138585504119899e-07 6.669873381261692 -1.3134702046611901 FVLNLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVLNLIK 7 0 Q8TDN6 Q8TDN6 BRIX1 Ribosome biogenesis protein BRX1 homolog 0 15450900.0 2871300.0 4604100.0 7975500.0 False True 3764302.105708749 3917186.2266412345 7150271.766398124 1.0 1.0406142006245007 1.8994946647758122 21.84395098615732 -6.916761788884721 0.8483814493652735 0.978749071996879 2.0281879995352186 0.9932334755607518 0.03411971272766065 0.10011485713353406 0.11575874230517715 0.028904279993239315 0.08407600565882646 1.211262330416603e-07 6.916761788884721 1.0494389275383396 FVLNLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVLNLIK 7 0 Q8TDN6 Q8TDN6 BRIX1 Ribosome biogenesis protein BRX1 homolog 0 12778400.0 2871300.0 3714100.0 6193000.0 False True 3932897.2039649007 3549998.7811137373 4730340.948838631 1.0 0.9026421482704533 1.2027624175047842 21.907161047680212 -6.819371249474243 1.3746827808833944 0.9474918915988083 1.2092217785567594 0.8829145001329173 0.042778025881822036 0.19429805971421465 0.7216638949804268 0.024455364592181863 0.056372861127114995 1.515754096103225e-07 6.819371249474243 0.2617298869579511 FVLNLIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVLNLIK 7 0 Q8TDN6 Q8TDN6 BRIX1 Ribosome biogenesis protein BRX1 homolog 0 7971900.0 3381900.0 2154800.0 2435200.0 False True 2812199.693572831 2143191.6647056895 2944389.060907372 1.0 0.7621050772474899 1.047005683002048 21.423267612773788 -6.685122959694276 1.8835346280642455 0.8501809783825055 1.0459729930733164 0.3477961365304706 0.10071422894023191 0.42723684230474923 2.934655512432186 0.04283591819172345 0.1122470223982676 2.0647954774978335e-07 6.685122959694276 0.19579201469081087 FVLNSNITNIPQIQVTLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVLNSNITNIPQIQVTLLK 19 0 Q9NR09;A0A3B3IUB9;H7C3P0 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 0 17722600.0 7995200.0 0.0 9727400.0 False True 12129302.927414315 0.0 7804775.126329129 1.0 0.0 0.6434644408698039 23.531993305184407 -10.272419840136624 7.392788541103151 1.0000028350121093 0.321732220434902 0.5970125870666212 0.2626932579593829 1.2274738077779998e-05 1.2078842083070475e-06 0.2543527139507807 0.08478388443647156 5.340478363072274e-11 10.272419840136624 -0.6782706145772073 FVLPLQDHTIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVLPLQDHTIKK 12 1 P53618;E9PP73;E9PP63;E9PKQ1 P53618 COPB1 Coatomer subunit beta 1 3608000.0 1793500.0 1459600.0 354900.0 True False 1491374.7155217086 1451736.8450920836 429107.94912780274 1.0 0.9734219240697272 0.2877264477275876 20.50821135699579 -6.915081424546392 0.8604220196200898 1.0179734262065991 0.18876355866334338 0.992701741355739 0.028164772756622415 0.10115303748831442 0.12125327987822031 0.02365462713892588 0.06784149253388615 1.2159580030204143e-07 6.915081424546392 -0.8292098675432558 down FVLSGANIMCPGLTSPGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVLSGANIMCPGLTSPGAK 19 0 Q9ULC4;Q9ULC4-3;A0A3B3IRV3;Q9ULC4-2 Q9ULC4 MCTS1 Malignant T-cell-amplified sequence 1 0 10321500.0 2946700.0 4291800.0 3083000.0 False True 3863152.23588339 3651480.169305368 2764000.7342242394 1.0 0.9452074229402925 0.7154780773458681 21.881347100537937 -6.943795090672663 0.6232599008868044 1.0025096281926151 0.6459370220892002 0.9986198954196541 0.004578963028579748 0.08607721530144334 0.047040617654534565 0.004597744408058869 0.01946622577219357 1.138164169098453e-07 6.943795090672663 -0.3565726061034149 FVLSGANIMCPGLTSPGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVLSGANIMCPGLTSPGAK 19 0 Q9ULC4;Q9ULC4-3;A0A3B3IRV3;Q9ULC4-2 Q9ULC4 MCTS1 Malignant T-cell-amplified sequence 1 0 12199400.0 2946700.0 3178900.0 6073800.0 False True 4036174.621573287 3038445.6867834646 4639293.533837571 1.0 0.7528033278201152 1.1494283495665978 21.94455716206083 -6.738178658372944 1.6935251382816094 0.8526097999246863 1.1495630047930627 0.5966951637210245 0.10386647468828583 0.3211084817635154 1.807602459580849 0.0485352149753337 0.11933263314712846 1.8273483340577024e-07 6.738178658372944 0.2969532048683764 FVLSQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVLSQAK 7 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 15042800.0 1329500.0 7918600.0 5794700.0 False True 1742987.3748963126 6737175.746461047 5195120.030687388 1.0 3.8653038131511597 2.9805838559194595 20.733130688850625 -10.249341388150366 5.8415971271236975 0.9999001709419688 3.422943834535306 0.9090935317987938 0.3611854100791752 0.0004696557134467144 6.035058344532919e-05 0.3497300431599485 0.11657208984413472 5.631947683000173e-11 10.249341388150366 2.423043663593337 FVLSQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVLSQAK 7 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 10297900.0 4447700.0 1539000.0 4311200.0 False True 4306510.198047897 2153530.725778978 3181967.3867723136 1.0 0.5000640023458331 0.7388737609897386 22.038087816973963 -10.050553339182917 5.109926775383733 1.0000053553423136 0.6194688816663024 0.7719726405141827 0.097493675717628 5.948167148164974e-06 1.1052621529928045e-06 0.09439917449886112 0.03146594853383506 8.901161090096489e-11 10.050553339182917 -0.3805364736760112 FVLSQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVLSQAK 7 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 14021700.0 1329500.0 6330900.0 6361300.0 False True 1821052.078386562 6051179.904513329 4858891.955085937 1.0 3.3229032691226643 2.6681784737265053 20.796340750373517 -10.120775248162639 5.320114801433919 0.9999580751232543 2.995540871425796 0.9252968889707741 0.26729027844903275 0.00013292246295140215 2.196777140566914e-05 0.2588080668545468 0.08626756641907382 7.572246651505799e-11 10.120775248162639 1.9955827963025419 FVMEVEVDGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVMEVEVDGQK 11 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;Q96SI9-2;Q96SI9 Q12906-7;Q96SI9-2 ILF3;STRBP Interleukin enhancer-binding factor 3;Spermatid perinuclear RNA-binding protein 0 2697900.0 1668100.0 1029800.0 0.0 False True 1615147.0785717757 1441004.5103360552 0.0 1.0 0.8921816034303766 0.0 20.623234114964504 -7.125669824744917 0.9623825670952699 0.9969046230755387 2.327021536110901e-19 0.9896740891175354 0.04554027349970075 0.08600012158308343 0.15100641895171618 0.037868334826084545 0.06666019670139524 7.487385175992183e-08 7.125669824744917 -0.9969046230755387 down FVMEVEVDGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVMEVEVDGQK 11 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;Q96SI9-2;Q96SI9 Q12906-7;Q96SI9-2 ILF3;STRBP Interleukin enhancer-binding factor 3;Spermatid perinuclear RNA-binding protein 0 32615400.0 4390600.0 19636000.0 8588800.0 False True 6660861.195855676 16131802.38323175 6891219.915395231 1.0 2.421879379992005 1.0345839243254134 22.667277287561824 -6.6404753157218215 2.042875980801627 1.9295148784860836 1.0403791601782084 0.1563314503852804 0.6083130847918403 0.5322121281425886 4.245652487944003 0.24244910715963744 0.6735487881546653 2.288361772986518e-07 6.6404753157218215 -0.8891357183078752 FVMEVEVDGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVMEVEVDGQK 11 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;Q96SI9-2;Q96SI9 Q12906-7;Q96SI9-2 ILF3;STRBP Interleukin enhancer-binding factor 3;Spermatid perinuclear RNA-binding protein 0 3060140.0 889850.0 977390.0 1192900.0 False True 1218851.5922920525 934205.6780034881 911161.5885466834 1.0 0.7664638450746187 0.747557450233332 20.21709104302748 -13.999999999999998 0.3562704438713925 3.9855902405820873 0.7451581318759259 0.9997664695903394 0.0017544220732994742 21.299516477332794 0.19260269332419494 48.26802932120452 0.005522973621524506 1.0000000000000041e-14 13.999999999999998 -3.2404321087061616 FVMEVEVDGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVMEVEVDGQK 11 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;Q96SI9-2;Q96SI9 Q12906-7;Q96SI9-2 ILF3;STRBP Interleukin enhancer-binding factor 3;Spermatid perinuclear RNA-binding protein 0 3871800.0 1668100.0 2203700.0 0.0 False True 1387099.0593597793 2191828.230699799 0.0 1.0 1.58015263287068 0.0 20.40363939039878 -6.824219859895567 1.466944058352929 1.3160668016807628 4.8793363662905185e-21 0.8521277415018048 0.25096752825125845 0.2010190033896277 0.8668426174670544 0.13670074059564322 0.29848136578199225 1.498925818017097e-07 6.824219859895567 -1.3160668016807628 FVMEVEVDGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVMEVEVDGQK 11 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;Q96SI9-2;Q96SI9 Q12906-7;Q96SI9-2 ILF3;STRBP Interleukin enhancer-binding factor 3;Spermatid perinuclear RNA-binding protein 0 16783100.0 4390600.0 9088800.0 3303700.0 False True 5683718.251664929 8583000.2903027 2702460.498824596 1.0 1.5101030540682563 0.47547404342799104 22.438403609654273 -6.772645947730187 1.5643497303282925 1.2915906166054234 0.4690665685648446 0.7405751481483239 0.21514382252418346 0.2621694582324847 1.2665320994750533 0.10838109897917694 0.25736834973201145 1.687928523852994e-07 6.772645947730187 -0.8225240480405789 down FVMLLPSSTHTIPFYPNPLHPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVMLLPSSTHTIPFYPNPLHPR 22 0 Q9Y3I1-3;Q9Y3I1-2;Q9Y3I1 Q9Y3I1-3 FBXO7 F-box only protein 7 0 20884000.0 8689300.0 7160700.0 5034000.0 False True 8413462.927782342 10020004.852557182 3715444.383237114 1.0 1.1909489515274183 0.44160703091330406 23.004268296135997 -6.839137699329069 1.286477752513637 1.1015923365440126 0.4173907844019216 0.9229480363292013 0.08825477289656698 0.1698084911503639 0.5463038808858419 0.05380174278154737 0.12391585425984458 1.4483125723484953e-07 6.839137699329069 -0.684201552142091 down FVMLLPSSTHTIPFYPNPLHPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVMLLPSSTHTIPFYPNPLHPR 22 0 Q9Y3I1-3;Q9Y3I1-2;Q9Y3I1 Q9Y3I1-3 FBXO7 F-box only protein 7 0 12450400.0 1018900.0 3145300.0 8286200.0 False True 1395614.864737173 3006330.245883806 6329170.2196458345 1.0 2.1541259855024317 4.535040704684501 20.41246943824052 -6.9594340629906695 0.44333741761012946 0.9177710467433582 5.864740387840311 0.9997486312170687 0.02333572810361645 0.07990390059420016 0.0218829607454999 0.03152588421553966 0.1971535609327173 1.0979079681287087e-07 6.9594340629906695 4.946969341096953 FVMLLPSSTHTIPFYPNPLHPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVMLLPSSTHTIPFYPNPLHPR 22 0 Q9Y3I1-3;Q9Y3I1-2;Q9Y3I1 Q9Y3I1-3 FBXO7 F-box only protein 7 0 22441700.0 8689300.0 6394500.0 7357900.0 False True 7225537.951258874 6360051.559291134 8896402.870914238 1.0 0.8802184144895467 1.231244362831733 22.784673571570274 -6.8145931795640085 1.3949557412037343 0.9350652850924487 1.2380638509689883 0.8715362081749111 0.05221943582088171 0.2005942920689939 0.7683694113526429 0.029426489876656726 0.06794505738277487 1.5325223624753507e-07 6.8145931795640085 0.3029985658765396 FVMQEEFSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVMQEEFSR 9 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 16648400.0 3667300.0 6422300.0 6558800.0 False True 4807865.814183716 5464117.87392933 5880158.2924521435 1.0 1.1364955023930994 1.223028786515849 22.19696520083226 FVMQEEFSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVMQEEFSR 9 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 13578700.0 4963500.0 2183700.0 6431500.0 False True 4805936.409382542 3055662.7978450605 4746897.209135774 1.0 0.6358100768623459 0.9877153596681998 22.196386128637688 -10.715532560493072 9.644587773320547 1.0003397304333548 0.8117627185729134 0.27615091109913037 0.1436647301106921 0.0010513050799294851 3.10083779938828e-05 0.13934591616360453 0.04636759226300784 1.9251627038544468e-11 10.715532560493072 -0.1885770118604414 FVMQEEFSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVMQEEFSR 9 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 18522600.0 3667300.0 8417900.0 6437400.0 False True 5023199.9150560675 8045969.343727236 4917018.702414627 1.0 1.6017617215693531 0.9788618381834291 22.26017526235515 -6.6540212263003395 1.9940259887971106 1.3892336569903638 0.9814710187010319 0.21056121307738807 0.2565860682060825 0.49876588309407943 3.805683266556295 0.10419091930535367 0.2843022912176129 2.2180880072949417e-07 6.6540212263003395 -0.4077626382893319 FVMQEEFSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVMQEEFSR 9 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 8751600.0 4963500.0 2375100.0 1413000.0 False True 4127370.1703328774 2362304.8648795607 1708451.7670261625 1.0 0.5723511018855472 0.4139322853342165 21.976791404071964 -13.999999999999961 0.13795335524290184 3.0394157320212662 0.21296109461212945 0.9996112180771083 0.004880751504366226 11.93246644530348 0.11621551364431996 6.558848796353892 0.17942995085733338 1.00000000000009e-14 13.999999999999961 -2.8264546374091366 FVNQLK(ub)GESR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVNQLKGESR 10 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463;A0A087WYS0 B9A067 IMMT MICOS complex subunit MIC60 1 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 FVNVVPTFGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVNVVPTFGK 10 0 E9PR30;P62861 E9PR30 FAU 40S ribosomal protein S30 0 76808000.0 18743000.0 22160000.0 35905000.0 False True 24572254.507470217 18853814.379003476 32189895.02507993 1.0 0.7672806080236441 1.3100098330535308 24.550526895437486 -6.790169861748566 1.4955117868108403 0.869962067657632 1.3158207256065255 0.8019190636039193 0.09894456794463309 0.235096967602162 1.03872523672407 0.05207435980948295 0.12191124220480261 1.6211758971934402e-07 6.790169861748566 0.44585865794889357 FVNVVPTFGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVNVVPTFGK 10 0 E9PR30;P62861 E9PR30 FAU 40S ribosomal protein S30 0 54148000.0 20482000.0 10368000.0 23298000.0 False True 19831810.121279966 14507996.468405748 17195554.87498177 1.0 0.7315518038788779 0.8670693582594643 24.241313027800082 -10.12336710222473 4.993851758100845 1.0000084091038086 0.7993105810685825 0.7451663987709993 0.05532480990575825 5.17996032767945e-06 9.092556592626732e-07 0.053570261023046246 0.01785600561613256 7.527190333087384e-11 10.12336710222473 -0.20069782803522607 FVNVVPTFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVNVVPTFGK 10 0 E9PR30;P62861 E9PR30 FAU 40S ribosomal protein S30 0 69546800.0 11768000.0 52983000.0 4795800.0 False True 17852916.356040113 43527769.69193157 3847908.0279261894 1.0 2.438132169773202 0.21553386299400548 24.089656428590715 -6.7320166735977764 1.715747375865687 1.863502995508592 0.21632876617139918 0.5686502839128725 0.604466529278216 0.3324690330122839 1.918275249378284 0.2790768460728151 0.6909690416388168 1.853460463294683e-07 6.7320166735977764 -1.647174229337193 FVNVVPTFGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVNVVPTFGK 10 0 E9PR30;P62861 E9PR30 FAU 40S ribosomal protein S30 0 67468000.0 18743000.0 23833000.0 24892000.0 False True 25672793.610529825 22779979.254808355 19013022.266832095 1.0 0.887319845295879 0.7405903134372493 24.613736956960377 -6.967500753501929 0.3121663864955979 1.0220343286161766 0.6011970502342904 0.9999558021643188 0.0007060574109100777 0.07712231071384432 0.011918700612354977 0.002299186636813011 0.012999732436482938 1.077703383874841e-07 6.967500753501929 -0.4208372783818862 FVNVVPTFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVNVVPTFGK 10 0 E9PR30;P62861 E9PR30 FAU 40S ribosomal protein S30 0 31012000.0 20482000.0 10530000.0 0.0 False True 17031690.506448656 10473272.799958644 0.0 1.0 0.6149285530988942 0.0 24.02171830323436 -7.615366271939784 0.6730132513004812 0.9970037188248545 3.474778958182131e-21 0.9871638829975041 0.04665865260591959 0.12119867196588119 0.14726114570714002 0.04239066772765947 0.07728041071023427 2.4245644220778605e-08 7.615366271939784 -0.9970037188248545 down FVNVVPTFGKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVNVVPTFGKK 11 1 E9PR30;P62861 E9PR30 FAU 40S ribosomal protein S30 1 9078800.0 3143000.0 3422800.0 2513000.0 True False 3043227.1853912203 4789541.889666203 1854769.9116159836 1.0 1.5738364564624139 0.6094746788934013 21.537170608402743 -6.745520212012881 1.666515770877513 1.3392292949531655 0.6082037144421569 0.6294495609567221 0.24109475412782896 0.30791681154213224 1.6810899186956427 0.11435635784451101 0.27893473741752906 1.7967174592135008e-07 6.745520212012881 -0.7310255805110085 FVPLPASAK(ub)WASGLTPAQNCPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVPLPASAKWASGLTPAQNCPR 22 1 A0A0G2JKZ1;A2AB90;A0A0G2JH37;A0A0A0MSV9;O15533;O15533-3;Q6P1N7;O15533-2;C9JA35 A0A0G2JKZ1 TAPBP Tapasin 1 49844700.0 6633900.0 9209800.0 34001000.0 True False 8697107.142778996 7835733.739519219 30482902.68062223 1.0 0.9009586303676901 3.5049473555044646 23.052104176631232 -6.898058826446509 0.9734719813444563 0.8858941122908102 3.767742641317882 0.9855751430520934 0.1447087047790228 0.11284780521317975 0.18559396044819504 0.11188591075120924 0.2883696320224459 1.2645650468685045e-07 6.898058826446509 2.8818485290270717 up FVPLPASAK(ub)WASGLTPAQNCPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVPLPASAKWASGLTPAQNCPR 22 1 A0A0G2JKZ1;A2AB90;A0A0G2JH37;A0A0A0MSV9;O15533;O15533-3;Q6P1N7;O15533-2;C9JA35 A0A0G2JKZ1 TAPBP Tapasin 1 48567700.0 9912500.0 7959200.0 30696000.0 True False 9597833.113328185 11137350.066679683 22655796.73973903 1.0 1.1604025549489523 2.3605116355146554 23.194277297082696 -6.931364370314123 0.7355095120471482 0.9826427243456807 2.6156700716831343 0.9967996435334779 0.03434389274364211 0.09193545051047176 0.0742553967940638 0.03154683513642775 0.10778590902950572 1.1712123135204939e-07 6.931364370314123 1.6330273473374537 up FVPLPASAK(ub)WASGLTPAQNCPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVPLPASAKWASGLTPAQNCPR 22 1 A0A0G2JKZ1;A2AB90;A0A0G2JH37;A0A0A0MSV9;O15533;O15533-3;Q6P1N7;O15533-2;C9JA35 A0A0G2JKZ1 TAPBP Tapasin 1 299970700.0 7363700.0 81837000.0 210770000.0 True False 11171271.25858027 67232547.95460051 169111217.11622727 1.0 6.018343516899342 15.138045903803361 23.413290033926348 -6.961874449297284 0.40815849536855575 0.5416340997568354 20.952183690969804 0.9998335244843629 0.07550859215769098 0.07903821425971913 0.018706433659170213 0.11738121328100568 0.7618869770866489 1.091755907831942e-07 6.961874449297284 20.41054959121297 FVPLPASAK(ub)WASGLTPAQNCPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVPLPASAKWASGLTPAQNCPR 22 1 A0A0G2JKZ1;A2AB90;A0A0G2JH37;A0A0A0MSV9;O15533;O15533-3;Q6P1N7;O15533-2;C9JA35 A0A0G2JKZ1 TAPBP Tapasin 1 82981400.0 6633900.0 8763500.0 67584000.0 True False 9086632.104406651 8376299.592980868 51622051.13617148 1.0 0.9218266456412052 5.681098402909574 23.115314238154124 -6.903165918313809 0.9410242131569292 0.8189456990375489 6.214088980509071 0.9880769499977121 0.24299152058122017 0.10911266907490656 0.164563435576691 0.1924495878662319 0.5091694426206793 1.249781471191888e-07 6.903165918313809 5.395143281471522 up FVPLPASAK(ub)WASGLTPAQNCPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVPLPASAKWASGLTPAQNCPR 22 1 A0A0G2JKZ1;A2AB90;A0A0G2JH37;A0A0A0MSV9;O15533;O15533-3;Q6P1N7;O15533-2;C9JA35 A0A0G2JKZ1 TAPBP Tapasin 1 106629400.0 9912500.0 5603900.0 91113000.0 True False 8242682.94820684 5573710.678412948 110164307.04108624 1.0 0.6762010274367625 13.36510305361824 22.974682572516972 -6.901047114768979 0.9546523689081804 0.48749249729545785 14.725573356146043 0.987079313503748 0.6714172372590455 0.11063769801678729 0.17311666452251553 0.5264448071010585 1.3770143641182317 1.2558937097147047e-07 6.901047114768979 14.238080858850585 up FVPLPASAK(ub)WASGLTPAQNCPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVPLPASAKWASGLTPAQNCPR 22 1 A0A0G2JKZ1;A2AB90;A0A0G2JH37;A0A0A0MSV9;O15533;O15533-3;Q6P1N7;O15533-2;C9JA35 A0A0G2JKZ1 TAPBP Tapasin 1 169471700.0 7363700.0 59968000.0 102140000.0 True False 9532454.810227558 56630728.08389137 83551568.04490232 1.0 5.940833626940581 8.764958209427672 23.184416356018797 -8.437891667520377 0.35248324037323187 5.602577006882912e-20 9.796149490788633 0.9978665652013222 0.1482232554952606 0.15868941820028953 0.10098409535031247 0.8769819388254372 0.7762606172829859 3.648449442326113e-09 8.437891667520377 9.796149490788633 FVPYLIAGIQHSCQDIGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVPYLIAGIQHSCQDIGAK 19 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 142741100.0 32572100.0 68467600.0 41701400.0 False True 42702338.5286651 58252500.96461454 37386539.15607481 1.0 1.3641524790383779 0.8755150290183307 25.347811743221854 -6.707252082586788 1.8057832665721067 1.2245090760620034 0.8767917894243149 0.4517127504329339 0.15352015408696673 0.3806103967334646 2.417765139868258 0.06771106506263223 0.17254311653271928 1.9622209915190285e-07 6.707252082586788 -0.3477172866376885 FVPYLIAGIQHSCQDIGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVPYLIAGIQHSCQDIGAK 19 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 208020900.0 130500200.0 36163100.0 41357600.0 False True 126357542.58319785 50603214.41807515 30524803.858594973 1.0 0.40047640515607824 0.2415748457477041 26.91293654386115 -13.999999999999726 0.18638894940028564 4.174739946572999 0.1233407686795482 0.999491806049205 0.00736212867133131 12.294127069346603 0.13690104183821747 14.159075637577423 0.11250051022042021 1.0000000000006298e-14 13.999999999999726 -4.051399177893451 FVPYLIAGIQHSCQDIGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVPYLIAGIQHSCQDIGAK 19 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 274610400.0 68259800.0 102055000.0 104295600.0 False True 103555107.05982554 83842487.8906455 83681528.94561462 1.0 0.8096412651305385 0.8080869338223018 26.625823464257493 FVPYLIAGIQHSCQDIGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVPYLIAGIQHSCQDIGAK 19 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 198318500.0 32572100.0 65242300.0 100504100.0 False True 44614885.59790523 62359679.45856517 76767101.52691302 1.0 1.3977325868452544 1.7206611761550141 25.411021804744745 -6.973497484458407 0.15309961552435108 0.640495779935777 2.486413987125279 0.9999984070019655 0.0003719540386535391 0.07518332144582639 0.004693680772482143 0.015981969997109383 0.03978643513937921 1.0629247399821671e-07 6.973497484458407 1.8459182071895022 FVPYLIAGIQHSCQDIGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVPYLIAGIQHSCQDIGAK 19 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 199372000.0 130500200.0 19842000.0 49029800.0 False True 108516698.43910016 19735107.207671374 59281704.49181845 1.0 0.18186239990287545 0.5462910809536606 26.693341819295426 -10.648043786953934 6.522407632711667 1.0032196066791714 0.36407674048284605 0.80237045489937 0.14877738603498344 0.006984353668074063 0.00037688259041101466 0.1444439137706483 0.04801769486714689 2.2488278604125812e-11 10.648043786953934 -0.6391428661963254 FVPYLIAGIQHSCQDIGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVPYLIAGIQHSCQDIGAK 19 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 274328000.0 68259800.0 124206200.0 81862000.0 False True 88363656.70181715 117294015.78397535 66963955.97505196 1.0 1.327401107672395 0.7578223726188879 26.396949786349943 -6.750895125268364 1.6472558679071834 1.1923158745207925 0.756662574840293 0.6525215431041811 0.13758039381816387 0.29848556487662314 1.5939258579506939 0.06598039495754218 0.15998681684043656 1.7746179692116337e-07 6.750895125268364 -0.4356532996804995 FVPYLIAGIQHSCQDIGAK(ub)SLTQVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVPYLIAGIQHSCQDIGAKSLTQVR 25 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 16864800.0 6444500.0 4362700.0 6057600.0 True False 6239922.875040956 6104748.861179949 4470932.835895336 1.0 0.9783372300318504 0.716504502608294 22.573096766923946 -6.923290093602497 0.7999471618384799 1.0051212157336615 0.6709120611126245 0.9950470902998589 0.009067287838017565 0.09627444347915556 0.09586515364174242 0.007951735562076982 0.024622950769244693 1.193190828261711e-07 6.923290093602497 -0.33420915462103706 FVPYLIAGIQHSCQDIGAK(ub)SLTQVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVPYLIAGIQHSCQDIGAKSLTQVR 25 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 51171000.0 15595000.0 16631000.0 18945000.0 True False 23658755.14721662 13663068.111403923 15200512.446111504 1.0 0.5775057912550966 0.642489951458828 24.495870829597397 -10.582439313772497 6.417306735960438 1.0008155525932834 0.6099978713569864 0.9796017963328573 0.026529672310403155 0.0003101576435589123 2.018127374880964e-05 0.02573721352003156 0.008562414919877626 2.6155359050439244e-11 10.582439313772497 -0.390817681236297 FVPYLIAGIQHSCQDIGAK(ub)SLTQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVPYLIAGIQHSCQDIGAKSLTQVR 25 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 18476000.0 6444500.0 4359300.0 7672200.0 True False 5358887.289757273 4335815.5856466945 9276421.547755236 1.0 0.8090887811605909 1.7310350164456256 22.353502042358222 -6.8527075635144845 1.2220400841708698 0.8978412087784523 1.769842890138032 0.9441409597677773 0.09390715877790996 0.1545057611887201 0.4426674847368833 0.060087905864571606 0.1393017763390329 1.4037586211455937e-07 6.8527075635144845 0.8720016813595798 FVPYLIAGIQHSCQDIGAK(ub)SLTQVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVPYLIAGIQHSCQDIGAKSLTQVR 25 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 41309000.0 15595000.0 15712000.0 10002000.0 True False 20188034.92340787 14837613.388041971 8181738.629186548 1.0 0.7349706617971952 0.4052766235162336 24.266997151689846 -6.96818026307617 0.2984678466701578 1.0582311601125192 0.07170786952039902 0.9999645056411205 0.0014493379246992015 0.07689769695161694 0.011132343750382577 0.005511727058691753 0.029617149301007322 1.0760184967756714e-07 6.96818026307617 -0.9865232905921202 down FVQAVIPTIEYDYTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVQAVIPTIEYDYTR 15 0 Q9NT62 Q9NT62 ATG3 Ubiquitin-like-conjugating enzyme ATG3 0 3015900.0 1345000.0 1670900.0 0.0 False True 1842282.8472583145 1597074.1130725981 0.0 1.0 0.8668995184150816 0.0 20.813063145959838 -7.156255118180367 0.9318216778463038 0.9936319413945057 1.816949327299854e-21 0.989659931402024 0.04508506105807796 0.08840732105653808 0.14536234000580278 0.037750434154647045 0.06629368779824367 6.978223609429121e-08 7.156255118180367 -0.9936319413945057 down FVQLEGAHPLEKSK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVQLEGAHPLEKSK 14 1 Q9BVI4;F5H303 Q9BVI4 NOC4L Nucleolar complex protein 4 homolog 1 4358060.0 757160.0 2049800.0 1551100.0 True False 992644.0923478695 1743977.830057818 1390607.051201823 1.0 1.7569014347658511 1.4009120307286211 19.920917013696872 -10.098614123128868 4.562795306225289 0.9999562764340294 1.5789067327667445 0.7790541487174732 0.1453320656852299 101149795.64052255 3.879719068023638 47443.90371773619 0.049751031680853174 7.968670637702515e-11 10.098614123128868 0.5789504563327151 FVQLEGAHPLEKSK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVQLEGAHPLEKSK 14 1 Q9BVI4;F5H303 Q9BVI4 NOC4L Nucleolar complex protein 4 homolog 1 11672400.0 2082300.0 1309900.0 8280200.0 True False 2016198.5262933907 1832949.901038261 6111367.219324577 1.0 0.9091118147020885 3.031133660512988 20.94320627105763 -6.896891390900946 0.9806878869019509 0.9040926471296065 3.2403501190345794 0.9849559597186799 0.12015336684143425 0.11373063608358451 0.19059476543092083 0.09239883507696435 0.23687309460458697 1.2679689220252087e-07 6.896891390900946 2.3362574719049727 up FVQLEGAHPLEKSK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVQLEGAHPLEKSK 14 1 Q9BVI4;F5H303 Q9BVI4 NOC4L Nucleolar complex protein 4 homolog 1 26925600.0 2481600.0 6213000.0 18231000.0 True False 3764768.629261486 5104241.607609429 14627634.859068833 1.0 1.3557915798429026 3.8854007508924275 21.844129773484614 -6.932359660816909 0.7271662812986641 0.964697537860985 4.437356731820033 0.9969818972129135 0.0705706802155851 0.09143135720317697 0.07181392985123294 0.06522000150784778 0.22599027845322328 1.1685312714546874e-07 6.932359660816909 3.472659193959048 up FVQLEGAHPLEKSK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVQLEGAHPLEKSK 14 1 Q9BVI4;F5H303 Q9BVI4 NOC4L Nucleolar complex protein 4 homolog 1 29048200.0 2481600.0 3655600.0 22911000.0 True False 3212480.1196491867 3452162.6464693397 18741433.086711958 1.0 1.0746098085881157 5.833945235047426 21.615256095577063 -6.91030895020082 0.8936366189068153 0.8540778076488768 6.453073884263628 0.9910374462024976 0.21408497337097082 0.10421384576651851 0.13766480841287515 0.17554244140582229 0.4856148756592805 1.2293938883626622e-07 6.91030895020082 5.5989960766147515 up FVSFLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVSFLGR 7 0 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 0 6643400.0 2821900.0 2014000.0 1807500.0 False True 3699538.2273184736 1713519.0505105115 1620477.2387642935 1.0 0.4631710622307901 0.43802148787062534 21.81891377554334 -13.744375592369394 0.4388390187502985 9.999999999950054 0.4377550435298961 0.999882782662612 0.0028062176272816777 26.350378353162363 0.22340405550316755 227.05408986333 0.005828454018788303 1.8014591049903704e-14 13.744375592369394 -9.562244956420159 FVSFLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVSFLGR 7 0 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 0 7828800.0 2821900.0 3184800.0 1822100.0 False True 3865232.688980102 3044085.0052747712 1391757.5073274449 1.0 0.7875554333257999 0.3600708209095376 21.88212383706623 -6.959925509198157 0.43648201323348806 1.0158579395942744 0.11519827531643818 0.9997674271973737 0.004058436328606911 0.07972774170805916 0.021229686953930155 0.005612493898775449 0.03544430835270286 1.0966662817591946e-07 6.959925509198157 -0.9006596642778362 down FVSFLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVSFLGR 7 0 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 0 11870000.0 3826400.0 4209700.0 3833900.0 False True 4953350.229620263 3975426.4943762897 3136169.5391359995 1.0 0.8025732706328453 0.6331410850745409 22.239973200527277 -6.972905647636121 0.17539974296413863 1.1392436558648564 0.2919096504135598 0.999997076927179 0.00025624425509351845 0.07537063300804091 0.00550328830643447 0.0067980798083976625 0.019287774051082618 1.0643742330356859e-07 6.972905647636121 -0.8473340054512966 FVSISDLLVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVSISDLLVPK 11 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 77655000.0 22681000.0 31663000.0 23311000.0 False True 29735010.64311643 26939003.821407333 20899001.334901463 1.0 0.9059692005741264 0.7028415622827269 24.82565925631269 -6.9585105835714645 0.45594793743873324 1.006166549791724 0.5945112686020138 0.9997108801648875 0.002108594905226616 0.08023764797226547 0.02313086502492409 0.002740217501975333 0.01678832912881941 1.100245032466418e-07 6.9585105835714645 -0.4116552811897103 FVSISDLLVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVSISDLLVPK 11 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 93520000.0 34763000.0 32518000.0 26239000.0 False True 33659467.59330412 45502606.979129754 19366218.74687297 1.0 1.351851655199133 0.575357251067319 25.004509021313904 -6.783506708906243 1.5220488884788455 1.1983251950511027 0.568501005623459 0.7796199794920902 0.14903352246694684 0.2451828336910117 1.1220600145486972 0.07710115195014505 0.18141266359067343 1.646240535292049e-07 6.783506708906243 -0.6298241894276437 FVSISDLLVPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVSISDLLVPK 11 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 62233000.0 14360000.0 33855000.0 14018000.0 False True 21785169.856622715 27813310.739677697 11247336.155692346 1.0 1.2767084637268697 0.5162840698381401 24.3768430260463 -6.808259434558581 1.421964553510038 1.1511183338498396 0.503520776915309 0.8551910199650292 0.11958508953876615 0.20919212073407806 0.83400468502823 0.06613492559882202 0.15309886712658174 1.5550364217554362e-07 6.808259434558581 -0.6475975569345306 FVSISDLLVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVSISDLLVPK 11 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 177842000.0 22681000.0 75825000.0 79336000.0 False True 31066778.630978294 72474800.780256 60598470.776208945 1.0 2.33287144576965 1.9505875229620064 24.88886931783558 -10.133607405406428 5.095577326299242 0.9999560677133952 2.1417294843676253 0.9224388097029391 0.15606675796429936 7.78960701019446e-05 1.3244721235885516e-05 0.1511167637593244 0.050370329540128086 7.351781560166859e-11 10.133607405406428 1.1417734166542302 FVSISDLLVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVSISDLLVPK 11 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 67365000.0 34763000.0 15386000.0 17216000.0 False True 28906974.762019053 15303112.564118098 20815786.002209805 1.0 0.5293917018333201 0.7200956230660193 24.78491429674818 -10.180786554936944 5.376028983764236 1.0000147983335188 0.6247436624495873 0.8377330446873145 0.07785454982829389 1.3809468926105051e-05 2.1043279440412785e-06 0.07538531399138043 0.025127447909246328 6.594979426357222e-11 10.180786554936944 -0.37527113588393146 FVSISDLLVPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVSISDLLVPK 11 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 40231000.0 14360000.0 15089000.0 10782000.0 False True 18589303.077918403 14249283.885702994 8819786.63266241 1.0 0.7665313662365982 0.47445493764309715 24.147969348138748 -6.96809774028714 0.3001685441048377 1.0505544750653144 0.1812776925849963 0.9999635084445231 0.0012987469475472704 0.07692493907451424 0.011227868978197076 0.004841589237938608 0.02619034558055762 1.076222976657318e-07 6.96809774028714 -0.8692767824803181 down FVSSHQGFSGILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVSSHQGFSGILK 13 0 Q96PZ0;Q96PZ0-2;E7EUH7 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 8088700.0 3899400.0 2759900.0 1429400.0 False True 5112151.161843319 2348133.6780059393 1281499.3997729893 1.0 0.45932399173409 0.2506771335984735 22.285499065471654 -12.902960982066833 0.1460850658607057 2.895817991192235 2.317457685074554e-24 0.9995978847706731 0.006331906197329438 7.9729123832703355 0.1100905974426356 4.570505730453085 0.21156537489011965 1.2503713611745775e-13 12.902960982066833 -2.895817991192235 FVSSHQGFSGILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVSSHQGFSGILK 13 0 Q96PZ0;Q96PZ0-2;E7EUH7 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 6830110.0 2160300.0 972110.0 3697700.0 False True 2091722.4589884358 1360278.5924866786 2729161.4413778065 1.0 0.6503150485578828 1.3047435761136486 20.996260009052463 -6.761572124530818 1.606824260792916 0.7972820123675558 1.307300749094489 0.6972819638856639 0.14711156951682325 0.28026721299306057 1.4265692414739506 0.07222928757747901 0.1732911022068241 1.7315214481354474e-07 6.761572124530818 0.5100187367269332 FVSSHQGFSGILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVSSHQGFSGILK 13 0 Q96PZ0;Q96PZ0-2;E7EUH7 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 10446200.0 3899400.0 2925800.0 3621000.0 False True 5341113.557322732 2796528.4816732393 2765794.3768358915 1.0 0.5235852882849054 0.5178310378823445 22.348709126994546 FVSSHQGFSGILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVSSHQGFSGILK 13 0 Q96PZ0;Q96PZ0-2;E7EUH7 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 4303800.0 2160300.0 1071700.0 1071800.0 False True 1796385.1675168958 1065926.5393842047 1295908.424556719 1.0 0.5933730464149911 0.7213978649957486 20.77666528448674 -10.78810983035024 10.426089485703535 1.0021165080533034 0.6573854557053705 0.9052050929241984 0.05226591332254047 0.0025805799590903566 5.244524855256801e-05 0.05078780459790196 0.01686875098937663 1.6288840459898955e-11 10.78810983035024 -0.3447310523479329 FVSSLLTALFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVSSLLTALFR 11 0 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 0 327909000.0 140030000.0 97242000.0 90637000.0 False True 135584824.29854685 136071237.71033087 66896450.64828404 1.0 1.0035875210540746 0.49339187474981305 27.01462046903001 -6.905316920085151 0.9270542611640206 1.0182300871865362 0.43366162429172767 0.9890306156335751 0.02510152580389972 0.10759638366225098 0.15617507456016644 0.020086494341140196 0.053802550592312454 1.2436067766040782e-07 6.905316920085151 -0.5845684628948085 down FVSSLLTALFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVSSLLTALFR 11 0 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 0 3742500000.0 1292600000.0 1188800000.0 1261100000.0 False True 1960968701.7179992 976649351.8632054 1011843032.2402353 1.0 0.49804433441878276 0.5159914237049079 30.868919363388546 -10.113133983936972 7.920368339228276 1.0000000466149805 0.5070178790800659 0.9990069850958576 0.007326868519862905 6.031346469019455e-09 6.806894592539865e-10 0.00709421057358673 0.002364736646440032 7.706656747681932e-11 10.113133983936972 -0.49298216753491464 FVSSLLTALFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVSSLLTALFR 11 0 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 0 666410000.0 140030000.0 188280000.0 338100000.0 False True 116441149.38082258 187265698.26934606 408795146.80222666 1.0 1.6082432994275133 3.5107446892786656 26.795025744464287 -6.950508603368188 0.5532306911291142 0.9741789118706384 4.234682691079629 0.9992406018618918 0.029470739557802685 0.08328213367998823 0.03512195337803132 0.03185569114651017 0.15792725101867602 1.1207052247604292e-07 6.950508603368188 3.260503779208991 FVSSLLTALFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVSSLLTALFR 11 0 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 0 3748600000.0 1292600000.0 1455500000.0 1000500000.0 False True 1673296180.9552426 1374500145.512673 818419265.9969152 1.0 0.8214326675436535 0.48910603831636085 30.640045685480995 -6.961428053411303 0.4148169852537651 1.015535344807251 0.28257308125482594 0.9998195505086506 0.002843749160746753 0.0791948761814065 0.01927514629020253 0.004286806668346396 0.027705087935822128 1.092878661906746e-07 6.961428053411303 -0.7329622635524251 down FVSVSK(ub)LK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVSVSKLK 8 1 E9PIZ0;C9JST7;A6NGW1;O95070 E9PIZ0 YIF1A Protein YIF1A 1 6255680.0 391720.0 620060.0 5243900.0 True False 513548.713421876 527549.4649749498 4701311.531040703 1.0 1.027262752660374 9.154558093846521 18.970141606440592 -6.9076329952227065 0.9116785868936658 0.72913893477548 10.153468318622112 0.9899978364583245 0.3838100924325919 0.10600484415032349 0.1474022987051259 0.3105982572613248 0.8439869526345848 1.2369923242833916e-07 6.9076329952227065 9.424329383846633 up FVTDSNAVVQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVTDSNAVVQLK 12 0 Q14008-2;Q14008;Q14008-3;E9PQH5 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 4757500.0 1103800.0 1701200.0 1952500.0 False True 1447092.489214406 1447387.5912256634 1750474.0297025067 1.0 1.0002039275398475 1.2096490326287297 20.464725702297294 -6.90710837907814 0.9151974620462081 0.9929073246216182 1.2351070309509364 0.9897839240496087 0.009984296561451136 0.1063614690324066 0.14936787650534358 0.008059162139490707 0.021825586555585915 1.2384874808735977e-07 6.90710837907814 0.2421997063293182 FVTDSNAVVQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVTDSNAVVQLK 12 0 Q14008-2;Q14008;Q14008-3;E9PQH5 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 4100900.0 1103800.0 1583700.0 1413400.0 False True 1511904.6890734038 1513726.8974044381 1079584.0298867302 1.0 1.0012052402140184 0.7140556132201504 20.527935763820185 -6.905955690065896 0.922850653411576 1.0100673682816732 0.6799873461770694 0.9893034085473231 0.013970603538661594 0.10715314026944792 0.15372948160284494 0.011213956505904524 0.030152717275729095 1.2417789966040514e-07 6.905955690065896 -0.33008002210460385 FVTHVSDWGALATISTLEAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVTHVSDWGALATISTLEAVR 21 0 A0A3B3IRL2;O75629 A0A3B3IRL2 CREG1 Protein CREG1 0 10841800.0 5388700.0 3080600.0 2372500.0 False True 5217638.668125249 4310699.645116777 1751071.0765256337 1.0 0.8261782617203838 0.33560604478477835 22.314965607432462 -6.9528149261613805 0.5270346859552832 1.0079055038665266 0.131721407743925 0.999404078844658 0.0068675648000274744 0.08237470520582539 0.03143382291353818 0.007695747687408414 0.0405527030888285 1.1147694894640961e-07 6.9528149261613805 -0.8761840961226015 down FVTHVSDWGALATISTLEAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVTHVSDWGALATISTLEAVR 21 0 A0A3B3IRL2;O75629 A0A3B3IRL2 CREG1 Protein CREG1 0 11798200.0 5388700.0 3195500.0 3214000.0 False True 4480942.809886724 3178285.2072429145 3886032.5401430186 1.0 0.7092893933460535 0.8672354691894083 22.09537088286674 -10.079817406077964 4.857732064228634 1.0000071745922776 0.7882624316432764 0.7055503151102613 0.06448121545534147 5.010528908099765e-06 9.491226116203206e-07 0.06243578362137797 0.02081122279917515 8.321135497597651e-11 10.079817406077964 -0.21174474294900125 FVTHVSDWGALATISTLEAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVTHVSDWGALATISTLEAVR 21 0 A0A3B3IRL2;O75629 A0A3B3IRL2 CREG1 Protein CREG1 0 14946000.0 4538400.0 6069800.0 4337800.0 False True 5875048.265238499 5732010.294216975 3548364.90958662 1.0 0.9756533113322912 0.6039720440394668 22.48616927321189 -6.920213553997374 0.8231588107158677 1.0081381191950844 0.5437432027548275 0.9942396188710798 0.013754356370184595 0.09804637563859014 0.10497025483713936 0.011864160022515514 0.0356107274687111 1.201673394961152e-07 6.920213553997374 -0.464394916440257 FVTLSATNAK(ub)TNDVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVTLSATNAKTNDVR 15 1 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 220163900.0 78889700.0 98616600.0 42657600.0 True False 103425160.66894147 83903387.68449597 38243800.752592936 1.0 0.8112473516291294 0.36977269849267475 26.6240119578719 -6.956872706721522 0.47747130826491824 1.0108529548149272 0.15183931820660193 0.9996360532664647 0.005038232907726856 0.0808377580754545 0.025407034055182253 0.00619309193130002 0.03642158078327233 1.1044022767564583e-07 6.956872706721522 -0.8590136366083253 down FVTLSATNAK(ub)TNDVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVTLSATNAKTNDVR 15 1 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 278781000.0 99820400.0 65402400.0 113558200.0 True False 96651656.04092458 91517919.38901031 83813900.74702364 1.0 0.9468841315068567 0.8671750095159764 26.526291116167563 -6.965250061737428 0.35373802272725346 1.007379077030443 0.8039748938406929 0.9999181925127489 0.0004936887685044344 0.07787623002865061 0.014561555761714183 0.001084172174537101 0.006834568038141654 1.0833029810902238e-07 6.965250061737428 -0.20340418318975007 FVTLSATNAK(ub)TNDVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVTLSATNAKTNDVR 15 1 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 421026000.0 125442000.0 117746000.0 177838000.0 True False 190304685.03861168 96733306.34630308 142688241.35083577 1.0 0.5083075402304282 0.7497883792082427 27.50373583830816 -10.093734224094572 5.252502654507309 1.0000064439822198 0.6290479597189004 0.7588248178736103 0.09858413969399586 7.439365664630656e-06 1.283494846201735e-06 0.0954553400038365 0.031817894269366355 8.058714608044905e-11 10.093734224094572 -0.37095848426331945 FVTLSATNAK(ub)TNDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVTLSATNAKTNDVR 15 1 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 228132700.0 78889700.0 71239000.0 78004000.0 True False 108057354.00398076 68091425.42413004 59581061.742807835 1.0 0.6301415211557151 0.5513836822305764 26.68722201939479 -13.999999999999998 0.21738819485813635 3.206671544896592 0.5081869718286952 0.9994954140575661 0.004393249599849253 12.929871527471667 0.1477252204446278 12.231630446794986 0.04434974715826663 1.0000000000000041e-14 13.999999999999998 -2.698484573067897 FVTLSATNAK(ub)TNDVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVTLSATNAKTNDVR 15 1 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 296200600.0 99820400.0 133941000.0 62439200.0 True False 83005085.39351185 133219433.24779294 75494948.03375798 1.0 1.6049550773452508 0.9095219609238436 26.30669639160184 -6.676773938885498 1.9137756434218378 1.3838717985836564 0.9122572398793828 0.30927754034910204 0.2565780737440182 0.4457047092338051 3.1533507973504675 0.10770096400744908 0.2851890533544646 2.1048737939934776e-07 6.676773938885498 -0.4716145587042736 FVTLSATNAK(ub)TNDVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVTLSATNAKTNDVR 15 1 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 322330600.0 125442000.0 118440000.0 78448600.0 True False 162387141.8314929 111848709.88287252 64171759.75061025 1.0 0.6887781176599347 0.39517759243031986 27.27486216040061 -7.162574154366318 0.22971616798039785 1.1312367543547308 1.2215635892668046e-10 0.9999819137720882 0.0010502220123520826 0.08481541978405711 0.010174767271392104 0.010983933066898537 0.03502082967787401 6.877424724987779e-08 7.162574154366318 -1.1312367542325745 down FVTPLK(ub)EALEAYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVTPLKEALEAYR 13 1 Q9NRF9 Q9NRF9 POLE3 DNA polymerase epsilon subunit 3 1 18848900.0 4499800.0 4335100.0 10014000.0 True False 4356956.312065992 6066128.037247854 7391032.986439509 1.0 1.392285715706753 1.6963752805992247 22.05488921650387 -6.973970602973973 0.13256284932834475 0.5463872009298935 2.5501594514895407 0.9999991514691565 0.00026251521148762147 0.07503413361401715 0.003988359547965845 0.01860446573208304 0.04101730121971541 1.061767424905003e-07 6.973970602973973 2.0037722505596474 FVTPLK(ub)EALEAYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVTPLKEALEAYR 13 1 Q9NRF9 Q9NRF9 POLE3 DNA polymerase epsilon subunit 3 1 21744500.0 2721300.0 9328700.0 9694500.0 True False 4128411.0536787896 7663920.599534222 7778377.825749712 1.0 1.8563850595024862 1.8841093400373663 21.977155192115397 -11.094328335899638 0.5834507213103665 2.7081567490514696e-12 1.881050728514706 0.9999122636271881 0.0038440670526765997 3.1298895990886457 0.28764276542519823 4.147687102206834 0.004929741919215169 8.04769788010693e-12 11.094328335899638 1.881050728511998 FVTPLK(ub)EALEAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVTPLKEALEAYR 13 1 Q9NRF9 Q9NRF9 POLE3 DNA polymerase epsilon subunit 3 1 13822000.0 4499800.0 6065400.0 3256800.0 True False 3741783.0749398354 6032724.486312357 3937781.822258184 1.0 1.6122592799983089 1.0523811090576116 21.835294491938146 -10.217784685069109 4.423387092910811 0.9998847832885535 1.3323201945341658 0.31961134967309124 0.22856930617558827 0.00025980050859912535 4.594263805558354e-05 0.22138769613271142 0.07377042635307893 6.056410656362866e-11 10.217784685069109 0.3324354112456124 FVTPLK(ub)EALEAYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVTPLKEALEAYR 13 1 Q9NRF9 Q9NRF9 POLE3 DNA polymerase epsilon subunit 3 1 16878500.0 2721300.0 9263600.0 4893600.0 True False 3522776.4948425745 8748072.516641142 4003015.0125762075 1.0 2.4832891128484933 1.136323867959467 21.748281514207846 -6.623213655607677 2.1054289760099043 1.9820194500043 1.1416115474094763 0.09349156257074198 0.6373548089777269 0.5768902519421163 4.863962374245921 0.2483854651684674 0.7062956344119763 2.381147751197925e-07 6.623213655607677 -0.8404079025948237 FVTTLFVNQSSK(ub)CR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVTTLFVNQSSKCR 14 1 Q5VXN5;A0A5F9ZHD5;P17707-2;P17707 Q5VXN5 AMD1 S-adenosylmethionine decarboxylase proenzyme;S-adenosylmethionine decarboxylase alpha chain;S-adenosylmethionine decarboxylase beta chain 1 28505100.0 8912400.0 12016000.0 7576700.0 True False 12207555.128553893 11485093.388401663 5787239.507034663 1.0 0.940818474088856 0.47407031515246734 23.541270957322013 -6.9303621299042675 0.7438130335001796 1.0070032706841778 0.3773594640192887 0.9966089524656305 0.013697526415557009 0.09245021294467974 0.07676201335007495 0.012506094013102282 0.042148867815640215 1.1739182926599087e-07 6.9303621299042675 -0.6296438066648891 down FVTVQTISGTGALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVTVQTISGTGALR 14 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 89881000.0 28889000.0 28031000.0 32961000.0 False True 37873758.761473946 23848884.063982185 29550511.90423784 1.0 0.6296941429600543 0.780237105335774 25.174695272057598 -10.104461844494919 5.120886825407474 1.000007654610113 0.7049656252791757 0.8366306086406434 0.061458907033267375 5.371128577077904e-06 9.393504720147978e-07 0.05950887462136364 0.019835776951040284 7.862092615485051e-11 10.104461844494919 -0.29504202933093737 FVTVQTISGTGALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVTVQTISGTGALR 14 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 82582000.0 24015000.0 10703000.0 47864000.0 False True 23252656.97014638 14976763.715407655 35326982.51077891 1.0 0.6440882749285822 1.519266488820375 24.470892239728766 -6.796303422472533 1.4710109472852924 0.8026984107632528 1.5302663141962733 0.8211193708823429 0.1519881604309188 0.22607732783604864 0.9661527123394811 0.08129947981838653 0.18950978402160057 1.598440877998708e-07 6.796303422472533 0.7275679034330206 FVTVQTISGTGALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVTVQTISGTGALR 14 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 46412700.0 9063700.0 23141000.0 14208000.0 False True 13750295.545227787 19011307.748541765 11399782.572412372 1.0 1.3826108454185102 0.8290572762538773 23.712959292088993 -6.720770092641971 1.7566846717540738 1.232584999817263 0.8298906505644231 0.5160992341587816 0.1609888315808417 0.3538168776575914 2.134288872322582 0.07275687581197343 0.18247206389872886 1.9020849415600668e-07 6.720770092641971 -0.40269434925284 FVTVQTISGTGALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVTVQTISGTGALR 14 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 82394000.0 28889000.0 24820000.0 28685000.0 False True 39570043.995870195 23723370.331235804 21910193.786119223 1.0 0.5995285305649835 0.5537065813827734 25.23790533358049 -13.999999999999998 0.30598189761048966 4.781463385162288 0.5431157951351192 0.9996631300389869 0.003679226370342547 16.988736109390274 0.17586268070109537 40.810048660288714 0.016145240921612458 1.0000000000000041e-14 13.999999999999998 -4.238347590027169 FVTVQTISGTGALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVTVQTISGTGALR 14 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 53693000.0 24015000.0 14717000.0 14961000.0 False True 19969536.54488645 14637716.599904202 18089275.92815177 1.0 0.7330023191575993 0.9058435526278574 24.251297515163042 -10.734084825687239 5.758901303992642 1.0053123091829583 0.8194229358927325 0.5927270579848491 0.07056213808589831 0.004930078339219722 0.00022764436241076526 0.06998657268744257 0.022773832139956002 1.8446550889789002e-11 10.734084825687239 -0.1858893732902258 FVTVQTISGTGALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVTVQTISGTGALR 14 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 33071200.0 9063700.0 16368000.0 7639500.0 False True 11733138.322237382 15457106.411371639 6249189.387889476 1.0 1.3173889190478867 0.5326102204084323 23.484085614181442 -6.796940737061243 1.4685178087992623 1.175806075126807 0.5225974215842353 0.8230059209339303 0.13560614558486772 0.22516688446263813 0.9589687745671225 0.0726583533508479 0.16929018678746083 1.5960969325074595e-07 6.796940737061243 -0.6532086535425716 FVVDVDK(ub)NIDINDVTPNCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVVDVDKNIDINDVTPNCR 19 1 P62195;J3QRW1;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 10648800.0 3065800.0 4945000.0 2638000.0 True False 4019293.4892494357 4207225.275459025 2365045.065482826 1.0 1.046757418116457 0.5884230827653433 21.938510496316606 -6.881758336483391 1.0699877492534482 1.0297085772379613 0.5548315326674201 0.9750744733449996 0.032511333478476574 0.1260819622148812 0.26299439596337676 0.023368562389545412 0.056770158299410706 1.3129302769078668e-07 6.881758336483391 -0.47487704457054114 FVVDVDK(ub)NIDINDVTPNCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVVDVDKNIDINDVTPNCR 19 1 P62195;J3QRW1;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 51689000.0 14165000.0 22019000.0 15505000.0 True False 13715339.828528978 30811301.527568083 11443775.359970476 1.0 2.2464847326260315 0.8343778209684991 23.70928703286945 -6.673712761362426 1.9246865149327592 1.7930834152564314 0.8400395918762666 0.2954590229265597 0.5290321857731547 0.45260638073985643 3.235990603414626 0.22103214104218005 0.5875964469459273 2.1197626645246822e-07 6.673712761362426 -0.9530438233801648 FVVDVDK(ub)NIDINDVTPNCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVVDVDKNIDINDVTPNCR 19 1 P62195;J3QRW1;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 195656000.0 86728000.0 61328000.0 47600000.0 True False 131572716.66609858 50383539.24214894 38191839.136178896 1.0 0.3829330313974654 0.2902717227698584 26.971285117387083 -13.999999999999998 0.26696815805594093 5.686165331113478 0.2585988804849853 0.999576851532197 0.006479898353636023 14.73663796349888 0.16353969457404935 37.41243607735944 0.0390763618383865 1.0000000000000041e-14 13.999999999999998 -5.427566450628492 FVVDVDK(ub)NIDINDVTPNCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVVDVDKNIDINDVTPNCR 19 1 P62195;J3QRW1;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 19564700.0 3065800.0 6577800.0 9921100.0 True False 4199309.110129772 6287171.046124219 7577940.511468256 1.0 1.49719177160786 1.8045683974986242 22.001720557839498 -9.15605694088832 0.11119660135700285 1.022358956872704e-06 2.6048015785191847 0.9999390971465878 0.002587002826962173 0.618882802148245 0.038724788484403534 0.5323122208877952 0.3415228508607249 6.981408639615272e-10 9.15605694088832 2.6048005561602277 FVVDVDK(ub)NIDINDVTPNCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVVDVDKNIDINDVTPNCR 19 1 P62195;J3QRW1;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 39266000.0 14165000.0 14618000.0 10483000.0 True False 11778825.115899084 14539249.932554167 12674946.832084415 1.0 1.2343548519902088 1.0760790407674654 23.489692308303727 -10.266778236675647 4.078257151198394 0.9998457092292413 1.1552169463884439 0.5618445221004131 0.0646158294404269 45720912.66102461 18.255706929260505 68149.92723927386 0.022119717084378685 5.4103051825475874e-11 10.266778236675647 0.15537123715920254 FVVDVDK(ub)NIDINDVTPNCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVVDVDKNIDINDVTPNCR 19 1 P62195;J3QRW1;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 194610000.0 86728000.0 69237000.0 38645000.0 True False 112271105.66446434 65383900.08578563 31612006.531185135 1.0 0.5823751329321833 0.28156849746952173 26.742411439479532 -8.052749675121774 0.2411771000939708 1.1939087791326883 1.1485493021721857e-10 0.9996371042560317 0.005611846831771137 0.09560688268110513 0.045791152562346144 0.07513964868687939 0.09934672855383789 8.856259325118216e-09 8.052749675121774 -1.1939087790178333 down FVVQNVSAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVVQNVSAQK 10 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 4874140.0 1751600.0 613240.0 2509300.0 False True 1695996.416777366 858109.9300043534 1852039.0526136062 1.0 0.5059621126056882 1.0920064655164445 20.69370169116928 -6.683167544079456 1.8903123675284033 0.6883201571191068 1.0898531195180048 0.338858808423638 0.20923970722479293 0.431503620043193 2.9836531592677633 0.08872479321163174 0.2330878269674764 2.0741132023660055e-07 6.683167544079456 0.401532962398898 FVVQNVSAQK(ub)DGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVVQNVSAQKDGEK 14 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 17846000.0 5029100.0 7129500.0 5687400.0 True False 6593198.801873678 6065806.390573328 5098922.405393101 1.0 0.9200096300523392 0.773360937325911 22.652547152299768 -6.961710363935355 0.4106206475884803 1.007175312772996 0.6807474898107121 0.9998284591007577 0.0012291673869781502 0.07909573950092033 0.01891503613780764 0.001888700476135375 0.012241615238474569 1.0921684735370242e-07 6.961710363935355 -0.326427822962284 FVVQNVSAQK(ub)DGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVVQNVSAQKDGEK 14 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 25449300.0 7933300.0 7725600.0 9790400.0 True False 7681461.733968868 10810472.368471762 7226000.534295714 1.0 1.407345729611048 0.9407064416321937 22.8729494422089 -6.676045040282889 1.9161500153968647 1.2586492132884752 0.9425437361805253 0.3059776993891501 0.17279544422712523 0.4473993407017364 3.172481507102245 0.07245586005630816 0.19205640347633376 2.108409477378798e-07 6.676045040282889 -0.3161054771079499 FVVQNVSAQK(ub)DGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVVQNVSAQKDGEK 14 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 77378000.0 13862000.0 14392000.0 49124000.0 True False 21029667.44794597 11823635.154790763 39414619.868185945 1.0 0.5622359547081479 1.8742388564035846 24.325922700444206 -6.816759781571022 1.3859748116765944 0.7632501467221475 1.9009077660161373 0.8767369856989382 0.1914882987909763 0.19772604167639604 0.7471993137116382 0.10859811446975279 0.2505262535196778 1.5248959761795623e-07 6.816759781571022 1.1376576192939898 FVVQNVSAQK(ub)DGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVVQNVSAQKDGEK 14 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 15706300.0 5029100.0 5787000.0 4890200.0 True False 6888494.176317314 5531311.204950106 3735235.476830406 1.0 0.8029782799217264 0.5422426703461795 22.71575721382266 -6.967255263952267 0.3169676119424725 1.0370024313260346 0.29984597642084826 0.9999523714591384 0.0012938584166697325 0.07720375534320774 0.012203686421616244 0.004001972381504494 0.022997375743171112 1.0783127393181034e-07 6.967255263952267 -0.7371564549051863 FVVQNVSAQK(ub)DGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVVQNVSAQKDGEK 14 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 26927400.0 7933300.0 13458000.0 5536100.0 True False 6596890.454780252 13385499.08279616 6693672.913965713 1.0 2.0290619003831925 1.014670921072417 22.653354717643175 -6.64285543261113 2.034339730559861 1.6714857881377714 1.0189218240834272 0.16561665183981067 0.4399919848107334 0.5261702972486636 4.165338218583462 0.1759248708849181 0.4871774416563452 2.275854888344048e-07 6.64285543261113 -0.6525639640543441 FVVQNVSAQK(ub)DGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVVQNVSAQKDGEK 14 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 63249000.0 13862000.0 19148000.0 30239000.0 True False 17944632.26087082 18082396.967555214 24735812.278341524 1.0 1.0076772098018858 1.3784518912811166 24.097049022536655 -6.911375903286125 0.8863249693964299 0.9890129740243513 1.4278035349599176 0.9914299171500489 0.016350754284300256 0.10351589575935054 0.13388976993031532 0.013478202441566788 0.037569760025835466 1.226377281638489e-07 6.911375903286125 0.43879056093556634 FVWNGHLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVWNGHLLR 9 0 F8WDN7;E9PGZ4;A0A5F9ZHN7;Q9NTJ5-2;Q9NTJ5 F8WDN7 SACM1L Phosphatidylinositide phosphatase SAC1 0 5450000.0 1702900.0 1277000.0 2470100.0 False True 2232518.3909070604 1086476.577707014 2214517.746872297 1.0 0.4866596316214821 0.9919370679730661 21.090240629266923 -10.943989006163367 10.291782493732741 1.0691338613566035 0.739298349797276 0.26196507743574615 0.20627864960049752 0.11264458468170269 0.0006130452820761111 0.06875633726791264 0.06657614788174014 1.1376560843630241e-11 10.943989006163367 -0.32983551155932744 FVYHLSDLCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVYHLSDLCK 10 0 D6RD17;D6RHJ6;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 0 107563500.0 29259200.0 27440200.0 50864100.0 False True 38359094.54649582 23346229.12106184 45601170.854899526 1.0 0.6086230500765187 1.188796852324693 25.193065330639076 -6.724973909672082 1.7413645397574211 0.7631668601834557 1.1881599298528742 0.535916715378477 0.16460035063479025 0.34573442110529573 2.051408997207021 0.07497715238604823 0.1871323473048479 1.8837622534849772e-07 6.724973909672082 0.4249930696694185 FVYHLSDLCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVYHLSDLCK 10 0 D6RD17;D6RHJ6;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 0 38043400.0 19889000.0 7634900.0 10519500.0 False True 19257634.581688166 10683555.385477517 7764127.371764562 1.0 0.5547698675119929 0.4031713936013393 24.19892717181434 -13.999999999745299 0.1503934757858377 3.154187634051044 0.2371351528699095 0.9995649314990918 0.005283258332631036 11.959202246486656 0.122154878674333 7.527715196052494 0.14971253623137273 1.000000000586471e-14 13.999999999745299 -2.9170524811811345 FVYHLSDLCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FVYHLSDLCK 10 0 D6RD17;D6RHJ6;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 0 140361600.0 18858000.0 112981000.0 8522600.0 False True 28608964.704470087 92818657.82541788 6838104.374411722 1.0 3.2443906581112727 0.23901963755239572 24.76996395485579 -6.7068363701384355 1.806701832608379 2.384305395629472 0.24682636880625106 0.4498618202104888 0.946265975966183 0.3815290889907608 2.4256732171714637 0.4171312573313971 1.0637074541704368 1.9641001547597812e-07 6.7068363701384355 -2.1374790268232213 FVYHLSDLCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVYHLSDLCK 10 0 D6RD17;D6RHJ6;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 0 111762600.0 29259200.0 45770400.0 36733000.0 False True 40077116.940149 43748112.38552764 28057421.939882025 1.0 1.0915982916351215 0.7000858365581252 25.256275392161967 -6.845067064670475 1.2586856877464425 1.0487445961455675 0.6858644654293312 0.9328122854154456 0.0433407983145457 0.1629662765946657 0.4993300611982161 0.02697522524951063 0.062255648746815696 1.4286733227263044e-07 6.845067064670475 -0.36288013071623626 FVYHLSDLCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVYHLSDLCK 10 0 D6RD17;D6RHJ6;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 0 37015700.0 19889000.0 4002200.0 13124500.0 False True 16538584.732094381 3980639.354225495 15868772.269168373 1.0 0.2406880285530576 0.9595000132250624 23.979332447248616 -9.817343366593446 11.031829019703085 0.9999919394330088 0.6000940208890918 0.29213060014328507 0.29345376394418365 0.0 0.0 0.2841353851427527 0.09471179504758422 1.5228482669650104e-10 9.817343366593446 -0.399897918543917 FVYHLSDLCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVYHLSDLCK 10 0 D6RD17;D6RHJ6;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 0 53662000.0 18858000.0 21978000.0 12826000.0 False True 24412052.746753808 20754904.979785327 10491799.605873497 1.0 0.850190895255427 0.42977949108637103 24.54109027694824 -6.9529406563959695 0.5255691321735907 1.0068486219112087 0.2541808124356725 0.9994123103851049 0.005851389585823489 0.08232596731965411 0.031238403548186716 0.006571615260974637 0.03474691695126237 1.1144468053207161e-07 6.9529406563959695 -0.7526678094755362 down FVYHLSDLCK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 FVYHLSDLCKK 11 1 D6RD17;D6RHJ6;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 1 139163700.0 27092500.0 45965200.0 66106000.0 True False 35518529.86414321 39107371.33094627 59265985.25352823 1.0 1.1010413854551475 1.66859342096134 25.082068533016578 -6.937246766072793 0.6846999382972574 0.9932249546539256 1.8099942962110778 0.9977805713680465 0.013863193828270762 0.08904541204743704 0.060500046177508364 0.013228304287306383 0.04946966228096487 1.15545552594476e-07 6.937246766072793 0.8167693415571522 FVYHLSDLCK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 FVYHLSDLCKK 11 1 D6RD17;D6RHJ6;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 1 135398600.0 51515200.0 48437400.0 35446000.0 True False 49879878.17399483 67778706.41770406 26161629.24279356 1.0 1.3588386519564695 0.5244926451410837 25.571954605762677 -6.78983457756783 1.4970659238577686 1.2005967296177316 0.5156678798701446 0.8007714683571296 0.15253062296669098 0.2355953080374746 1.0431327559004357 0.08019855145316873 0.18778126281412205 1.6224279612347854e-07 6.78983457756783 -0.6849288497475869 FVYHLSDLCK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FVYHLSDLCKK 11 1 D6RD17;D6RHJ6;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 1 206343100.0 27092500.0 28040600.0 151210000.0 True False 37109329.397283174 26801673.574135788 115497312.26770374 1.0 0.7222354596388362 3.1123524500057247 25.14527859453947 -6.877948026653041 1.091145423351399 0.8320892849913102 3.2752343506202224 0.9719937489056831 0.178610610514673 0.1294648742069302 0.28338282826347516 0.12631584966295478 0.303942277799135 1.3245000326743928e-07 6.877948026653041 2.4431450656289124 up FVYHLSDLCK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FVYHLSDLCKK 11 1 D6RD17;D6RHJ6;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 1 187156600.0 51515200.0 14961400.0 120680000.0 True False 42837171.3103117 14880799.968594631 145913630.0387243 1.0 0.3473805462269762 3.406238684196223 25.352359881196953 -6.850909984887678 1.2306051955336836 0.6514329079433666 3.530741024545478 0.9416290777510605 0.31780178348346755 0.1564601740623822 0.4554842276849601 0.20202453759089084 0.46780124671095696 1.409580928399052e-07 6.850909984887678 2.8793081166021115 up FVYHLSDLCK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FVYHLSDLCKK 11 1 D6RD17;D6RHJ6;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 1 652801100.0 26428100.0 188222000.0 438151000.0 True False 34211696.42573365 177747280.23956457 358412013.8089098 1.0 5.195512026871169 10.47630054203674 25.027986307759413 -6.968008053779227 0.3020013818396935 0.10564713064361134 15.732106711310973 0.999962409133686 0.023771230182768884 0.0769545186561764 0.011331475890171215 0.08675193497071 0.47261576957417467 1.0764452512928709e-07 6.968008053779227 15.626459580667362 FWDLSTETPHFTCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FWDLSTETPHFTCK 14 0 Q9NVX2 Q9NVX2 NLE1 Notchless protein homolog 1 0 3552900.0 1039400.0 1331500.0 1182000.0 False True 1362663.4655639173 1132845.3901463503 1059697.978544617 1.0 0.8313464173471031 0.7776666839057561 20.3779978757735 -13.999999999999998 0.16019599099841342 1.8309401949719162 0.7250108083459558 0.9995358498248056 0.0020407889728509434 12.011016678941704 0.12649019067074688 3.1010273526405863 0.04800303734787099 1.0000000000000041e-14 13.999999999999998 -1.1059293866259603 FWEVISDEHGIDPTGTYHGDSDLQLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FWEVISDEHGIDPTGTYHGDSDLQLDR 27 0 P07437;Q5JP53 P07437 TUBB Tubulin beta chain 0 31878700.0 15687000.0 1690700.0 14501000.0 False True 15189024.771629667 2365805.3268840252 10702753.079324855 1.0 0.15575755273656008 0.7046372785773349 23.85652590717199 -10.078085450428755 6.527676065286528 1.000000546719857 0.43019741573784764 0.5896462792590407 0.2240792097447765 1.7829889728510948e-06 2.5184916419675443e-07 0.21696397040763185 0.07232125396440221 8.354386237589884e-11 10.078085450428755 -0.5698031309820093 FWEVISDEHGIDPTGTYHGDSDLQLDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FWEVISDEHGIDPTGTYHGDSDLQLDR 27 0 P07437;Q5JP53 P07437 TUBB Tubulin beta chain 0 429007000.0 19473000.0 387233000.0 22301000.0 False True 29541964.666992635 318128245.68476176 17893197.57512448 1.0 10.76868953269746 0.6056874611022952 24.81626243889497 -6.655140405805743 1.9899071632498295 7.312860373511684 0.6481002780520485 0.21526108603839567 4.164139874991682 0.4960625499926518 3.770618963666395 1.693638666593839 4.614735251397494 2.2123793398850985e-07 6.655140405805743 -6.664760095459636 FWEVISDEHGIDPTGTYHGDSDLQLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FWEVISDEHGIDPTGTYHGDSDLQLDR 27 0 P07437;Q5JP53 P07437 TUBB Tubulin beta chain 0 22144700.0 15687000.0 3291000.0 3166700.0 False True 13044435.551931456 3273270.7297876426 3828842.328833513 1.0 0.2509323394451497 0.29352303620884435 23.636931182606265 -10.020841532166784 6.016226493032106 1.0000009357426272 0.27222768782693973 0.997437961590374 0.01738757914364969 2.1822717853843825e-07 3.552723448062659e-08 0.01683547268519742 0.0056118170378213015 9.531438891268895e-11 10.020841532166784 -0.7277732479156874 FWEVISDEHGIDPTGTYHGDSDLQLDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FWEVISDEHGIDPTGTYHGDSDLQLDR 27 0 P07437;Q5JP53 P07437 TUBB Tubulin beta chain 0 56168000.0 19473000.0 17226000.0 19469000.0 False True 25208182.370216236 16267357.957129013 15925841.768809516 1.0 0.6453205438702747 0.6317727131181852 24.58738876098742 FWNLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FWNLIK 6 0 O60306;H0YH15 O60306 AQR Intron-binding protein aquarius 0 3073600.0 775830.0 727170.0 1570600.0 False True 1017120.6431484082 618679.0704864588 1408089.378259032 1.0 0.6082651794101748 1.3843877692821318 19.95605938022971 -6.769478498254659 1.5763906324685413 0.7751618874700014 1.388673278660403 0.7285817139551576 0.16507478370769024 0.26727461705852495 1.3106932023798439 0.08254340268608637 0.19658645086976062 1.7002841319428838e-07 6.769478498254659 0.6135113911904017 FWNLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FWNLIK 6 0 O60306;H0YH15 O60306 AQR Intron-binding protein aquarius 0 2623730.0 775830.0 696600.0 1151300.0 False True 1062675.3170174118 665821.9086518481 879386.6517677886 1.0 0.6265525301938849 0.8275214806305508 20.019269441752602 -10.062056896018856 5.0096324996847725 1.0000054620229104 0.7270370054107157 0.710960537048692 0.08204523045729625 5.005217005906944e-06 9.370624786932209e-07 0.07944154167651214 0.02647998426565909 8.668483043214756e-11 10.062056896018856 -0.2729684566121947 FWSFFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FWSFFLR 7 0 Q6PKG0-3;Q6PKG0;Q659C4-7;Q659C4-6;Q659C4-5;A0A3B3ISF0;Q659C4-2;Q659C4;Q659C4-9 Q6PKG0-3;A0A3B3ISF0 LARP1;LARP1B La-related protein 1;La-related protein 1B 0 2457740.0 722100.0 859180.0 876460.0 False True 946680.0928263472 730993.6930574091 785772.3267979816 1.0 0.772165485042578 0.8300294183350051 19.85251745930125 -9.933058275203999 5.306148916004765 1.000000433799124 0.8010974516875085 0.9403143973249225 0.023622851850640687 1.2122735273573034e-07 2.4408670885119877e-08 0.02287277771055335 0.00762424264997298 1.1666530608312143e-10 9.933058275203999 -0.1989029821116155 FWSFFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FWSFFLR 7 0 Q6PKG0-3;Q6PKG0;Q659C4-7;Q659C4-6;Q659C4-5;A0A3B3ISF0;Q659C4-2;Q659C4;Q659C4-9 Q6PKG0-3;A0A3B3ISF0 LARP1;LARP1B La-related protein 1;La-related protein 1B 0 22986100.0 8549500.0 8534700.0 5901900.0 False True 12970216.552172415 7011616.103084538 4735386.878105335 1.0 0.5405936034206109 0.3650969788405108 23.62869923139846 -13.999999999990518 0.1333468502542294 3.1851353200009824 0.12946168524244964 0.9996307367387578 0.005144122230354322 11.932985640466724 0.11387579915454343 6.815073080202276 0.20985390161443274 1.0000000000218336e-14 13.999999999990518 -3.055673634758533 FWSFFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FWSFFLR 7 0 Q6PKG0-3;Q6PKG0;Q659C4-7;Q659C4-6;Q659C4-5;A0A3B3ISF0;Q659C4-2;Q659C4;Q659C4-9 Q6PKG0-3;A0A3B3ISF0 LARP1;LARP1B La-related protein 1;La-related protein 1B 0 3460000.0 722100.0 1383400.0 1354500.0 False True 989079.8840187573 1322276.813707961 1034594.9968031541 1.0 1.3368756508679382 1.0460176306482578 19.91572752082414 -10.826249254587996 9.174917614440389 0.9951258491857063 1.191446640758087 0.3661497889680396 0.11874228952238824 0.012013228257269633 0.000227501176479143 0.1166654312033998 0.038323909150895764 1.49193789604763e-11 10.826249254587996 0.1963207915723807 FWSFFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FWSFFLR 7 0 Q6PKG0-3;Q6PKG0;Q659C4-7;Q659C4-6;Q659C4-5;A0A3B3ISF0;Q659C4-2;Q659C4;Q659C4-9 Q6PKG0-3;A0A3B3ISF0 LARP1;LARP1B La-related protein 1;La-related protein 1B 0 2970260.0 833930.0 943530.0 1192800.0 False True 693449.7443629884 938447.0166139578 1442208.9651159307 1.0 1.353302130749254 2.079759891527196 19.403431805889127 -6.959499815658206 0.44243492158055886 0.9746746171413044 2.486825340823614 0.9997511732327239 0.007090505510372656 0.07988039846378621 0.0217959514288882 0.009607657545393382 0.060164480557021074 1.0977417562240082e-07 6.959499815658206 1.5121507236823093 up FWSFFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FWSFFLR 7 0 Q6PKG0-3;Q6PKG0;Q659C4-7;Q659C4-6;Q659C4-5;A0A3B3ISF0;Q659C4-2;Q659C4;Q659C4-9 Q6PKG0-3;A0A3B3ISF0 LARP1;LARP1B La-related protein 1;La-related protein 1B 0 35026500.0 8549500.0 12162000.0 14315000.0 False True 11067496.285840068 11485174.008742772 11709816.884303672 1.0 1.0377391337765423 1.0580366671805799 23.39982555349091 -13.999999034929026 0.07640669437819529 0.7917645572992822 1.122895150109199 0.9999010255878056 0.00023916778240611826 12.294040823697577 0.07671046875658627 0.4402640515825537 0.05917629068560763 1.000002222160508e-14 13.999999034929026 0.33113059280991686 FWVLAAHPNLNLFAAGHDGGMIVFK ddPTM_RPMI8226_Bortezomib_8h_R1 2 FWVLAAHPNLNLFAAGHDGGMIVFK 25 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 416694700.0 123379700.0 157406000.0 135909000.0 False True 187176025.16428623 129315669.4813088 109046526.57896918 1.0 0.6908773138429838 0.5825881091515752 27.479820415218622 -13.999999999999998 0.14622606313465764 2.4867367198838344 0.45811960275529234 0.9995793196921726 0.0036274871714990597 11.945537354496025 0.12022345938449622 5.052640691427128 0.11180370162173683 1.0000000000000041e-14 13.999999999999998 -2.028617117128542 FWVLAAHPNLNLFAAGHDGGMIVFK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FWVLAAHPNLNLFAAGHDGGMIVFK 25 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 344558600.0 123379700.0 107455700.0 113723200.0 False True 159717453.82748234 101475695.83384821 93026744.49857111 1.0 0.6353450634359377 0.5824457018896212 27.25094673731107 -13.999999999999998 0.2719000128485733 3.843473910200769 0.5652072973029418 0.9995874269839018 0.003770472213329477 14.977006514893711 0.16508393579672234 23.567199263031576 0.021763549512819707 1.0000000000000041e-14 13.999999999999998 -3.278266612897827 FWYFVSQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FWYFVSQLK 9 0 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 118291000.0 29023000.0 54658000.0 34610000.0 False True 38049434.059131764 46503239.45521529 31028889.202562742 1.0 1.2221795305271994 0.8154888494357484 25.181371659697096 -6.758360463667265 1.6185506620288588 1.1293184587647853 0.8141184795504048 0.6842475849280933 0.09342906494369149 0.2856947055555985 1.4747001718105202 0.0455518999802495 0.10965032846421387 1.7443737247390116e-07 6.758360463667265 -0.3151999792143805 FWYFVSQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FWYFVSQLK 9 0 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 231185900.0 91736000.0 64437000.0 75012900.0 False True 88823890.89374769 90167030.13451578 55364771.15123697 1.0 1.0151213736220446 0.6233094564328987 26.404444433559423 -6.897923812480743 0.9743153281546483 1.017231032601721 0.5838752822534411 0.9855043047650476 0.021821298309910524 0.11294916653769341 0.18617088053192551 0.016861206519462636 0.04342967316804236 1.2649582374126976e-07 6.897923812480743 -0.43335575034828 FWYFVSQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FWYFVSQLK 9 0 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 280280000.0 106390000.0 74151000.0 99739000.0 False True 161401408.15084195 60918174.70559274 80025542.9328434 1.0 0.3774327337259663 0.49581688195714757 27.26607792460043 -9.963008882334599 6.014079588540298 1.0000003267763413 0.43662480784264357 0.9679444400022598 0.04833012613376007 2.1171861574822433e-07 3.652292640616436e-08 0.04679547060285382 0.015598481136293687 1.0889078224022169e-10 9.963008882334599 -0.5633755189336977 FWYFVSQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FWYFVSQLK 9 0 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 191904000.0 29023000.0 60511000.0 102370000.0 False True 39753587.41708401 57837423.936882034 78192314.3763298 1.0 1.4548982291853876 1.966924734514069 25.244581721219987 -6.9695903259942655 0.26778926945028775 0.8692539668597211 2.5679167651447146 0.9999790089383351 0.0018096082084542876 0.0764358604461857 0.009504748804931861 0.010174491514152366 0.0477677709369559 1.0725305562052097e-07 6.9695903259942655 1.6986627982849933 FWYFVSQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FWYFVSQLK 9 0 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 227215200.0 91736000.0 78801200.0 56678000.0 False True 76282548.59386657 78376682.2947864 68529107.75053704 1.0 1.0274523300482412 0.8983589171278299 26.1848497089937 -6.851117916253371 1.229702882103812 1.0146645468667708 0.8930864497432044 0.9419140861984003 0.013382673131049407 0.15623157447006833 0.4540624637553865 0.00851336813376377 0.0197147953673368 1.4089062112504783e-07 6.851117916253371 -0.12157809712356638 FWYFVSQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FWYFVSQLK 9 0 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 332630000.0 106390000.0 139450000.0 86790000.0 False True 137723952.2604275 131689484.91359818 70995110.54060198 1.0 0.9561843292485644 0.5154884780416017 27.03720424669288 -6.926102911325328 0.7781254848771727 1.007758007126943 0.43338744932558065 0.9957150416451696 0.014322941811509038 0.094712846698115 0.08797111099801058 0.012758060695123254 0.0407633132530293 1.1854877992223635e-07 6.926102911325328 -0.5743705578013623 FWYFVSQLKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FWYFVSQLKK 10 1 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 17908400.0 4422300.0 6231000.0 7255100.0 False True 5797678.1256141225 5301359.088247764 6504411.847833369 1.0 0.9143934819055196 1.1218994409325518 22.467043809679268 -6.794656371972104 1.4774789848417964 0.9524425861278166 1.1244046812747754 0.816119521585227 0.03651116897760441 0.2284765629768075 0.9850921463837956 0.01944543384909212 0.04538099816053788 1.6045144329765503e-07 6.794656371972104 0.17196209514695882 FWYFVSQLKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FWYFVSQLKK 10 1 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 15281200.0 6910900.0 2596600.0 5773700.0 False True 6691517.2623354 3633435.921090116 4261394.762712772 1.0 0.54299133942935 0.6368353537244715 22.67390193993124 -9.956441602278971 5.801279527836837 1.0000003621609883 0.5899133465767208 0.9622086493621014 0.03831165840699774 1.7943396996615885e-07 3.2300806893119597e-08 0.0370951363556146 0.012365034581214983 1.1054991111250525e-10 9.956441602278971 -0.4100870155842675 FWYFVSQLKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FWYFVSQLKK 10 1 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 64061000.0 13688000.0 17384000.0 32989000.0 False True 20765696.726842023 14281689.378188074 26468709.69040767 1.0 0.6877539225412729 1.2746362445038435 24.307698941825297 -6.762157129458685 1.6042276767492762 0.8191168928547576 1.2770208053605863 0.6997475921714666 0.13137590077005215 0.27931414182163505 1.417185104905073 0.06459823770484568 0.15491850917392744 1.729190618029523e-07 6.762157129458685 0.4579039125058286 FWYFVSQLKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FWYFVSQLKK 10 1 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 22978900.0 4422300.0 10723000.0 7833600.0 False True 6057343.818163901 10249222.403780892 5983465.018056236 1.0 1.692032466944832 0.9878034329360458 22.53025387120216 -10.52668961838608 5.674013725505553 0.9992988604353342 1.3399179499404374 0.23701468749199728 0.2875002992291052 0.0025550140183530027 0.00021313173120940377 0.2789216511055711 0.0927903225786643 2.973790581343665e-11 10.52668961838608 0.3406190895051032 FWYFVSQLKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FWYFVSQLKK 10 1 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 14449200.0 6910900.0 4094800.0 3443500.0 False True 5746719.554780587 4072740.4996458376 4163519.929054916 1.0 0.708707021601185 0.7245037606874974 22.454307215365517 -10.571999204307456 9.650734136024486 1.0000209831021547 0.716605391146399 0.9976751096734567 0.006448991726890725 2.911765385034044e-06 1.2913104224016964e-07 0.006244670354486473 0.002081403129839769 2.679173233461212e-11 10.571999204307456 -0.2834155919557557 FWYFVSQLKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FWYFVSQLKK 10 1 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 90239000.0 13688000.0 42499000.0 34052000.0 False True 17719385.830818027 40133893.2903765 27854885.403025433 1.0 2.264970900998982 1.5720006138463036 24.078825263917746 -10.312760033789333 5.4990112593686105 0.9998472672701343 1.9184857574226633 0.7008105529958732 0.28290393507240497 0.0005298197030562349 6.621379042714539e-05 0.27396506456274383 0.09130685242598696 4.866760406675913e-11 10.312760033789333 0.918638490152529 FYALSASFEPFSNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYALSASFEPFSNK 14 0 P27797 P27797 CALR Calreticulin 0 342305000.0 122990000.0 207540000.0 11775000.0 False True 161241081.0368541 176575840.98458382 10556635.953775682 1.0 1.0951045468631206 0.0654711310907349 27.2646441199463 -6.897403031463644 1.075986399376877 1.0618978036425468 1.776504567599204e-12 0.9769641800563371 0.07051230339886112 0.11916995671352308 0.2542391312286042 0.051008916107983124 0.11932579259931698 1.26647601256341e-07 6.897403031463644 -1.0618978036407702 down FYALSASFEPFSNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYALSASFEPFSNK 14 0 P27797 P27797 CALR Calreticulin 0 846300000.0 389700000.0 272020000.0 184580000.0 False True 377329186.81099564 380639004.56556046 136232960.71869424 1.0 1.0087716982153907 0.36104538286600496 28.491248457547755 -6.903832338121378 0.9367345936691677 1.0241722391163106 0.28750962092322596 0.9883780333139917 0.032696758009239234 0.10863873785044548 0.1619427859025679 0.02597839974544982 0.06898730688614188 1.2478651667779448e-07 6.903832338121378 -0.7366626181930847 down FYALSASFEPFSNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FYALSASFEPFSNK 14 0 P27797 P27797 CALR Calreticulin 0 2956037200.0 953487200.0 1024000000.0 978550000.0 False True 1446509791.6515024 841259199.4514825 785139163.5862988 1.0 0.5815786414352605 0.542781782824915 30.429928943115684 -13.999999999999998 0.33646409795056875 5.736435487649231 0.5364201613793994 0.9997280964419106 0.003413273174897083 19.38410328120187 0.1858522369608038 65.1854737898493 0.012140218254228969 1.0000000000000041e-14 13.999999999999998 -5.200015326269832 FYALSASFEPFSNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYALSASFEPFSNK 14 0 P27797 P27797 CALR Calreticulin 0 725400000.0 122990000.0 217460000.0 384950000.0 False True 168462726.67977682 207851898.1559444 294032738.29411155 1.0 1.2338153504486526 1.7453875055283006 27.327854181469192 -6.9582513527173875 0.45941953557255927 0.9850018321312847 2.014803252291098 0.9996997304692791 0.005393702000332462 0.08033184821435652 0.023485254072508035 0.0069408980599943845 0.04226367469852315 1.1009019659794962e-07 6.9582513527173875 1.0298014201598131 FYALSASFEPFSNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYALSASFEPFSNK 14 0 P27797 P27797 CALR Calreticulin 0 817350000.0 389700000.0 212160000.0 215490000.0 False True 324052816.63719606 211017051.96953738 260547962.68681407 1.0 0.6511810456064896 0.8040293103778792 28.27165373298203 -10.003911049888075 4.558331334279858 1.0000073988610445 0.7276051779771338 0.8089645061189634 0.06240004287541513 86725375.93463537 120185794.57185681 9214.351552457743 0.0228360715620446 9.910349031212067e-11 10.003911049888075 -0.27240222088391075 FYALSASFEPFSNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FYALSASFEPFSNK 14 0 P27797 P27797 CALR Calreticulin 0 2740277200.0 953487200.0 1053700000.0 733090000.0 False True 1234307976.4426033 995060668.723258 599675142.1386092 1.0 0.8061688717196177 0.4858391532613536 30.201055265208133 -6.963597230568405 0.3813659419336231 1.0216684180383357 0.25898740619331145 0.9998812378921798 0.0023104612512614385 0.07844030845126711 0.016558916658156904 0.004163105766193269 0.02704997550983597 1.0874336539275026e-07 6.963597230568405 -0.7626810118450242 down FYAPWCGHCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYAPWCGHCK 10 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 52819600.0 13249100.0 15564100.0 24006400.0 False True 17369698.404466923 13241996.94838663 21522448.013649285 1.0 0.7623619385919342 1.2390801217431853 24.05006936850985 -6.771169072052175 1.5699281785121177 0.8638987368129294 1.2418832148577343 0.7350085797189704 0.1001849902594068 0.26455496826087177 1.2869804023868918 0.05029495065869154 0.11959737718418577 1.6936783183969564e-07 6.771169072052175 0.37798447804480495 FYAPWCGHCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYAPWCGHCK 10 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 58273900.0 13249100.0 17818800.0 27206000.0 False True 18147650.31346479 17031506.497108188 20780503.125158038 1.0 0.9384965107285282 1.1450795428728193 24.11327943003274 -6.826927602627764 1.341581617363903 0.9670601048012102 1.1502975858618123 0.8995847880442229 0.027444408014376795 0.18463667387402838 0.6509964122455099 0.01606664964032202 0.03698192306585716 1.4896093765511541e-07 6.826927602627764 0.18323748106060211 FYAPWCGHCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FYAPWCGHCK 10 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 45160600.0 11817600.0 8618000.0 24725000.0 False True 15298116.159722017 8138400.72416916 20225303.69992377 1.0 0.531987117838504 1.3220780577659885 23.866850671746583 -6.746248711743385 1.6640552872654522 0.723562933016403 1.3231790117561952 0.6325406581270839 0.19663535082292682 0.30663246373770847 1.669423041921494 0.0934008792033716 0.2276233399685325 1.793706113110214e-07 6.746248711743385 0.5996160787397923 FYAYNPLAGGLLTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYAYNPLAGGLLTGK 15 0 O43488;H3BLU7;A0A499FJT0;Q8NHP1 O43488 AKR7A2;AKR7L Aflatoxin B1 aldehyde reductase member 2;Aflatoxin B1 aldehyde reductase member 4 0 47291000.0 11209000.0 15084000.0 20998000.0 False True 14695107.54811042 12833525.996971484 18825328.38703882 1.0 0.8733196375021898 1.2810609466726555 23.80883258179607 -6.823239762667965 1.3576581579149485 0.9319308128895447 1.290605549344216 0.8916831699748398 0.05607809027239957 0.18931886851176977 0.6847615949626005 0.03244941490578276 0.0747391874631194 1.502312349600633e-07 6.823239762667965 0.3586747364546712 FYAYNPLAGGLLTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYAYNPLAGGLLTGK 15 0 O43488;H3BLU7;A0A499FJT0;Q8NHP1 O43488 AKR7A2;AKR7L Aflatoxin B1 aldehyde reductase member 2;Aflatoxin B1 aldehyde reductase member 4 0 75228000.0 40398000.0 13386000.0 21444000.0 False True 39115587.60274721 18731099.6070678 15827173.09378958 1.0 0.47886535151404086 0.40462572758789356 25.22124030181604 -13.999999999999998 0.27449478621859214 5.121162754235323 0.3810367779818458 0.9995930698823112 0.005343759140184047 15.108329647297941 0.1658969679535512 34.83922811596868 0.030156121598314312 1.0000000000000041e-14 13.999999999999998 -4.740125976253477 FYAYNPLAGGLLTGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FYAYNPLAGGLLTGK 15 0 O43488;H3BLU7;A0A499FJT0;Q8NHP1 O43488 AKR7A2;AKR7L Aflatoxin B1 aldehyde reductase member 2;Aflatoxin B1 aldehyde reductase member 4 0 30896300.0 7322200.0 16766000.0 6808100.0 False True 11108312.724523867 13773976.306644112 5462476.05090377 1.0 1.239970160025766 0.49174669334292687 23.405136362232554 -6.820417310193319 1.370206072639635 1.1292860465410903 0.4752839538646533 0.8853107745761237 0.10564014805328908 0.19294053235539163 0.711688066114493 0.060585939326620375 0.13961602809861254 1.512107577714817e-07 6.820417310193319 -0.654002092676437 down FYAYNPLAGGLLTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYAYNPLAGGLLTGK 15 0 O43488;H3BLU7;A0A499FJT0;Q8NHP1 O43488 AKR7A2;AKR7L Aflatoxin B1 aldehyde reductase member 2;Aflatoxin B1 aldehyde reductase member 4 0 53326000.0 11209000.0 20404000.0 21713000.0 False True 15353270.211835284 19502483.81299498 16584836.593271963 1.0 1.2702495001984149 1.0802152482464165 23.872042643318963 -10.351476537294253 3.9667633831444826 0.9995340541211717 1.1752323741921222 0.5313337094303726 0.0775811585412861 55785337.15179142 27585252.08990759 251748.23516183955 0.028391797550294834 4.4516751239034786e-11 10.351476537294253 0.17569832007095054 FYAYNPLAGGLLTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYAYNPLAGGLLTGK 15 0 O43488;H3BLU7;A0A499FJT0;Q8NHP1 O43488 AKR7A2;AKR7L Aflatoxin B1 aldehyde reductase member 2;Aflatoxin B1 aldehyde reductase member 4 0 60117600.0 40398000.0 10050000.0 9669600.0 False True 33592726.934845865 9995858.655231189 11691468.65282108 1.0 0.2975602032731212 0.3480357124771992 25.001645577250315 -10.16357177511356 8.081283592867422 1.0000001178432114 0.3227979578751603 0.9958506467756512 0.02060654034285783 4.376190534179748e-08 4.525178918764778e-09 0.01995220046034396 0.006650732297569973 6.861644678005462e-11 10.16357177511356 -0.6772021599680511 FYAYNPLAGGLLTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FYAYNPLAGGLLTGK 15 0 O43488;H3BLU7;A0A499FJT0;Q8NHP1 O43488 AKR7A2;AKR7L Aflatoxin B1 aldehyde reductase member 2;Aflatoxin B1 aldehyde reductase member 4 0 27251400.0 7322200.0 11355000.0 8574200.0 False True 9478732.242140252 10723084.268152805 7013783.578721376 1.0 1.131278318051907 0.7399495417266579 23.176262684325003 -6.816232573650119 1.3880400773538384 1.0710398568692063 0.7320739062666116 0.8755054177383743 0.05737742219721383 0.19842625898880284 0.7521800076663024 0.03249133503673235 0.07497488455657395 1.526748234116185e-07 6.816232573650119 -0.3389659506025947 FYCDYCDTYLTHDSPSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYCDYCDTYLTHDSPSVR 18 0 P09234;A0A0A0MRR7 P09234 SNRPC U1 small nuclear ribonucleoprotein C 0 14234700.0 1860300.0 8404900.0 3969500.0 False True 2438871.315170827 7150921.682043604 3558774.218132705 1.0 2.932061908130126 1.4591890092747417 21.217782206973357 -6.5773668204459135 2.277553431614959 2.317789112832023 1.462710148948374 0.0 0.8399113839476439 0.7073196701091761 6.897593091594599 0.3101913698957049 0.9393757575348617 2.646264066388255e-07 6.5773668204459135 -0.8550789638836491 FYCDYCDTYLTHDSPSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYCDYCDTYLTHDSPSVR 18 0 P09234;A0A0A0MRR7 P09234 SNRPC U1 small nuclear ribonucleoprotein C 0 14889000.0 1860300.0 5999500.0 7029200.0 False True 2548103.182717206 5734422.252306572 5369047.730918211 1.0 2.2504670498435586 2.107076262584018 21.28099226849625 -10.53886116032564 6.378553722923731 0.9986509413776784 2.1787716562137884 0.9890238218080523 0.058539043766975 0.0011238954373422407 8.125225899046255e-05 0.0567226729526428 0.018893395134366754 2.8916041520246685e-11 10.53886116032564 1.18012071483611 FYDLSSK(ub)YYQTIGNHASYYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYDLSSKYYQTIGNHASYYK 20 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 30155900.0 9933500.0 11495000.0 8727400.0 True False 9618166.479822999 16085013.445633085 6441432.123612153 1.0 1.6723575620547062 0.6697151829431314 23.197330467209284 -6.726020559168445 1.7376087105188096 1.406417190248455 0.6707273293277237 0.5406778968542149 0.28274499275927717 0.3438032630672654 2.031681312826006 0.1290447790867151 0.321684668634425 1.879227853488985e-07 6.726020559168445 -0.7356898609207313 FYDLSSK(ub)YYQTIGNHASYYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FYDLSSKYYQTIGNHASYYK 20 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 129851900.0 36491000.0 39641900.0 53719000.0 True False 55359514.84944419 32567493.221421637 43101416.10412591 1.0 0.5882907989709129 0.7785728654115662 25.7223279639895 -10.023937560594785 4.789359284779853 1.0000066906796727 0.6834318321835934 0.786800135181376 0.07768232835651204 19948546.629756346 41751508.008450024 844.5471755557205 0.026592729916307466 9.463732135962924e-11 10.023937560594785 -0.31657485849607936 FYDLSSK(ub)YYQTIGNHASYYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYDLSSKYYQTIGNHASYYK 20 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 26414700.0 5282500.0 9030200.0 12102000.0 True False 7235583.004194826 8631215.905121908 9243756.848513672 1.0 1.1928846507763042 1.2775414010390882 22.786677835338153 -13.999999999921474 0.11186068034074671 0.07215951211887979 1.4287623881100355 0.9997336219189151 0.0018955540915838395 12.002170543304674 0.10179147208611271 2.5066403522590703 0.1342619523390413 1.000000000180812e-14 13.999999999921474 1.3566028759911557 FYDLSSK(ub)YYQTIGNHASYYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYDLSSKYYQTIGNHASYYK 20 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 48960600.0 9933500.0 26406100.0 12621000.0 True False 8260145.378664575 26263845.09809956 15259992.747089325 1.0 3.1795863019478308 1.8474242337798201 22.97773574264356 -10.336600253602418 6.0037042839957415 0.9998425553278953 2.513505267863827 0.6324942715153488 0.5438528869504003 0.0011462351626751242 0.00012665872970014778 0.526635552061254 0.1755277644954762 4.606804118197665e-11 10.336600253602418 1.5136627125359317 FYDLSSK(ub)YYQTIGNHASYYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FYDLSSKYYQTIGNHASYYK 20 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 100956000.0 36491000.0 22842000.0 41623000.0 True False 47238318.84514761 21570822.62026828 34048041.08804551 1.0 0.4566382366607881 0.7207716514988334 25.49345428608195 -10.450494639985369 6.176585322254039 1.0001659918433483 0.5887049440798149 0.7637581493112489 0.10783201506201447 0.00024657975042039404 2.193724682254797e-05 0.10444945022749917 0.03480263321026408 3.5440950433704316e-11 10.450494639985369 -0.4114610477635334 FYDSNTVK(ub)QK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYDSNTVKQK 10 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 2689470.0 1013400.0 1009000.0 667070.0 True False 1328577.2137795603 858461.1330511954 598047.995387274 1.0 0.6461507273702443 0.45014169231906087 20.34145064562814 -10.657257309632907 0.1093283045189801 1.9168900566289535 5.663140807796332e-19 0.9998751157682882 0.0025427976970032245 2.64884236472773 0.060734998654564644 0.9080927427598465 0.27707422020360933 2.2016216656450268e-11 10.657257309632907 -1.9168900566289535 FYDSNTVK(ub)QK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYDSNTVKQK 10 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 3842800.0 1093300.0 1454300.0 1295200.0 True False 1058593.7899421623 2035009.5740743112 955948.2648328779 1.0 1.9223705952266135 0.9030359651789639 20.013717665112864 -6.668415132265787 1.9431501936308382 1.5895459425615326 0.9071959773483685 0.2720151380136273 0.391946430873335 0.46474263866139426 3.381582991756219 0.1624798192911153 0.4349792868525732 2.1457783925179743e-07 6.668415132265787 -0.682349965213164 FYDSNTVK(ub)QK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYDSNTVKQK 10 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 2546620.0 1013400.0 891510.0 641710.0 True False 1388081.366105261 852120.1403706701 490151.3144323006 1.0 0.6138834229592649 0.3531142528104015 20.40466070715103 -8.22296854814298 0.1888631317873716 1.2984169318956387 8.319115528103448e-16 0.9998265259507775 0.0035000117487401544 0.08660032173357683 0.039426897407450576 0.11041030971206565 0.11785847468317352 5.984549339426848e-09 8.22296854814298 -1.2984169318956378 down FYDSNTVK(ub)QK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYDSNTVKQK 10 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 4077230.0 1093300.0 2141700.0 842230.0 True False 909127.3914022216 2130162.2370058345 1018336.3989684678 1.0 2.343084431457192 1.1201250876379427 19.79412294054714 -6.623737803076075 2.1022827534981583 1.888773427337102 1.1248098440302134 0.09579603579938656 0.5770108328166356 0.5754153072753667 4.83723111708638 0.22508118437937397 0.63985683372181 2.3782756913979347e-07 6.623737803076075 -0.7639635833068885 FYDSNTVKQK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FYDSNTVKQK 10 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 3661980.0 878700.0 842080.0 1941200.0 True False 1137494.4717664951 795217.5077521886 1587921.5183940115 1.0 0.6990957121024416 1.395981745676545 20.117428103141492 -6.789352519975078 1.4988267086442844 0.8316827803706148 1.4032712238096587 0.7992455483251957 0.127867998150345 0.23631941126903047 1.0487845555418465 0.06715172026962167 0.1572993309312378 1.62422982142381e-07 6.789352519975078 0.5715884434390439 FYEAFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYEAFSK 7 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 22006400.0 4122600.0 11755000.0 6128800.0 False True 5404768.523315197 10001199.820631107 5494650.56760088 1.0 1.8504399915533356 1.0166301376086595 22.36580140052806 -10.227249751725182 4.242018621810518 0.9997773334579195 1.4335350646009029 0.264952737977454 0.3404014475249501 239934139.09251148 217.87776736190148 535645.988763538 0.11652846962349764 5.925844463111314e-11 10.227249751725182 0.4337577311429833 FYEAFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYEAFSK 7 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 8934010.0 4991600.0 964510.0 2977900.0 False True 4833144.390263703 1349643.872853203 2197898.6549149393 1.0 0.2792475796030511 0.4547554298900263 22.204530665270386 -10.648030663571994 9.958203891013845 1.0001978883658225 0.3670015047560114 0.9454864679264421 0.07165077984264526 0.00031488435091376607 1.1129510323494029e-05 0.069395827086684 0.023125189756111577 2.248895815853095e-11 10.648030663571994 -0.6331963836098111 FYEAFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYEAFSK 7 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 29811700.0 4122600.0 15781000.0 9908100.0 False True 5646836.629075936 15083743.239211624 7568010.843724869 1.0 2.6711846348705097 1.3402213205100852 22.42901146205095 -6.589260404553926 2.2310206443817666 2.13157491315601 1.3439853402408057 0.0 0.7243062914559056 0.6717541579788072 6.302091406181803 0.27109281117064865 0.8077644595637539 2.574776848481454e-07 6.589260404553926 -0.7875895729152043 FYEAFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYEAFSK 7 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 6673920.0 4991600.0 1038500.0 643820.0 False True 4150736.565373947 1032905.3943738902 778439.7853126571 1.0 0.24884869904549917 0.18754256577170325 21.984935940704663 -13.925479485242882 0.35559791530091345 9.999999999059325 0.17963330303554792 0.9997631847405882 0.005684543526196868 20.095795778327943 0.19214694760975337 136.6619373999572 0.017958671239977554 1.1871907790189866e-14 13.925479485242882 -9.820366696023777 FYEAFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FYEAFSK 7 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 21351900.0 6140800.0 7128100.0 8083000.0 False True 7949386.653264706 6731414.968896514 6611976.9385837745 1.0 0.8467841938638137 0.8317593830799921 22.92241212073635 -13.999999999999993 0.3283194398849085 2.651073489445923 0.8290458568267531 0.9997113374894714 0.0012915023828111807 18.682155706944158 0.18313724447898144 21.280973791935374 0.004845110313451763 1.0000000000000164e-14 13.999999999999993 -1.82202763261917 FYEAFSK(ub)NLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYEAFSKNLK 10 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 24837500.0 2814500.0 10885100.0 11137900.0 True False 3689836.7556567662 9261085.509787478 9985456.950280946 1.0 2.5098903076374897 2.7062056159998336 21.815125559860775 -10.444659522387424 0.4214680673437058 9.686414219966665e-23 2.7176324178529874 0.9993231904717635 0.019830780259126487 1.8722619394202311 0.19834044240782345 2.0986569737777216 0.04724635999317903 3.592034321174242e-11 10.444659522387424 2.7176324178529874 FYEAFSK(ub)NLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYEAFSKNLK 10 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 30092800.0 10034000.0 10896200.0 9162600.0 True False 9715476.162333911 15247109.482932352 6762640.187892016 1.0 1.5693630685898978 0.6960688364519082 23.211853274368288 -6.730794631625201 1.7205220691272387 1.3423471766344388 0.6965343215814442 0.5628178806318486 0.23933271569935338 0.3347735999097006 1.9418494054442894 0.11022278566848641 0.2732448800416829 1.8586831779891173e-07 6.730794631625201 -0.6458128550529946 FYEAFSK(ub)NLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FYEAFSKNLK 10 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 132029000.0 38485000.0 37162000.0 56382000.0 True False 58384558.630370826 30530150.75196872 45238072.9868915 1.0 0.5229148163173296 0.7748294077769955 25.7990835241896 -10.027038258469473 5.079897432315588 1.0000040079239447 0.6488721120450832 0.7214776061774817 0.1028437013135429 4.668293017856902e-06 8.941322327496847e-07 0.09957912200352094 0.03319266186976956 9.396405308067747e-11 10.027038258469473 -0.3511318958788615 FYEAFSK(ub)NLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYEAFSKNLK 10 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 29308400.0 2814500.0 13362900.0 13131000.0 True False 3855096.709002616 12772482.892799003 10029728.241433904 1.0 3.3131420187130605 2.601680061102482 21.878335621383666 -10.006530823319673 5.436141803626204 0.9999922188694718 2.9574110399105837 0.9098491253472702 0.2904531279344735 2.7391301627103115e-05 5.0054126561737745e-06 0.2812311479841105 0.09374334394390822 9.85074726302737e-11 10.006530823319673 1.957418821041112 FYEAFSK(ub)NLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYEAFSKNLK 10 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 32464500.0 10034000.0 14704400.0 7726100.0 True False 8343715.581569466 14625184.478605138 9341591.788549783 1.0 1.7528383291145355 1.119596143615506 22.992258549802564 -10.267528930646153 4.478161273256577 0.9997755328134029 1.4362172363662542 0.38752136203298493 0.2585200397045226 0.0005910113684409047 9.666887181772948e-05 0.2504408525091163 0.08343698403274666 5.400961349139274e-11 10.267528930646153 0.4364417035528513 FYEAFSK(ub)NLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FYEAFSKNLK 10 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 133212000.0 38485000.0 40250000.0 54477000.0 True False 49819591.1527639 38010052.117406435 44562744.98122324 1.0 0.7629539150743855 0.8944823502179821 25.57020984628205 -10.245380927237397 4.795399671878434 1.0000412107898786 0.8287181326458377 0.6933561942459587 0.053696258795955056 2.3663892212821236e-05 3.7238145155123076e-06 0.052003677479761694 0.01733039300569502 5.683541988077177e-11 10.245380927237397 -0.1713230781440409 FYEAK(ub)LQQQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYEAKLQQQQR 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 68449540.0 26529000.0 31253000.0 10667540.0 True False 34779775.90720141 26590174.223239828 9563765.291069234 1.0 0.7645297742626954 0.27498064727579186 25.051745301323812 -6.959279956667691 0.445467776583394 1.0165390879145006 0.003710271507060593 0.9997425481819804 0.004845447414456989 0.07995937376331314 0.022089520173511016 0.006500894214600678 0.040522714133854984 1.0982976221291283e-07 6.959279956667691 -1.0128288164074402 down FYEAK(ub)LQQQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYEAKLQQQQR 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 87384000.0 37022000.0 28767000.0 21595000.0 True False 35846756.8748182 40253813.1179232 15938621.663886666 1.0 1.122941560891967 0.4446321802428745 25.09533926564186 -6.859986362179364 1.1858063479183214 1.06670145057192 0.41179484610358336 0.9536195688583495 0.06354884516800526 0.14682112936648675 0.39230315739944843 0.0417984585729395 0.09756844453929972 1.3804276124449076e-07 6.859986362179364 -0.6549066044683365 down FYEAK(ub)LQQQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FYEAKLQQQQR 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 88060000.0 50057000.0 19193000.0 18810000.0 True False 75940128.65689155 15767859.194406547 15092195.255284121 1.0 0.2076354026952997 0.1987380785654556 26.178359107367935 FYEAK(ub)LQQQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYEAKLQQQQR 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 61999100.0 26529000.0 25970000.0 9500100.0 True False 36337488.219268225 24822559.528694395 7256372.04070109 1.0 0.6831115948056103 0.19969382575137223 25.114955362846704 -7.292532987873856 0.4433899457164249 1.0209310944545233 8.401053096241687e-25 0.9991897570215387 0.009366982768573716 0.10012038790906412 0.03790249281415456 0.012379435872007042 0.053252516320890356 5.098788670377356e-08 7.292532987873856 -1.0209310944545233 down FYEAK(ub)LQQQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYEAKLQQQQR 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 108073000.0 37022000.0 59896000.0 11155000.0 True False 30785433.352687318 59573328.35957481 13487458.925107468 1.0 1.935114171598125 0.43811171246449654 24.875744541076138 -6.737764598987006 1.694596003586289 1.5578015723581502 0.43760013987608154 0.5950427932747167 0.39292045632646716 0.32184771243815813 1.8138088287192846 0.18348533184166946 0.4514156367325302 1.829091371475396e-07 6.737764598987006 -1.1202014324820686 FYEAK(ub)LQQQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FYEAKLQQQQR 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 79763900.0 50057000.0 25074000.0 4632900.0 True False 64799773.270986155 23678609.858182576 3789759.737568316 1.0 0.3654119245010473 0.05848415119787412 25.949485429460385 -8.745102239069134 0.38865352154525423 1.1318783123750442 3.1989819986634316e-19 0.9971843268791443 0.020803540900866186 0.31408613159504617 0.13286869660448605 0.1396855537808698 0.07615278535053713 1.7984474852922797e-09 8.745102239069134 -1.1318783123750442 FYEEVHDLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYEEVHDLER 10 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2;Q99733;Q99733-2;C9J6D1;C9JZI7;E9PKT8;E9PNW0;E9PJJ2;E9PS34;E9PNJ7;A8MXH2 P55209;Q99733 NAP1L1;NAP1L4 Nucleosome assembly protein 1-like 1;Nucleosome assembly protein 1-like 4 0 26572800.0 1725800.0 13994000.0 10853000.0 False True 2262540.5126709724 11906149.748184755 9730035.669327175 1.0 5.262292401619504 4.300491246382449 21.109512194406747 -9.934816022727853 6.1937051553449045 0.9999990445319228 4.7813918240014255 0.9537244685102044 0.3926536773932995 67212692.40970007 1.1613764641900617 916.1783774758859 0.13441579774704165 1.1619407347927334e-10 9.934816022727853 3.7813927794695026 FYEEVHDLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYEEVHDLER 10 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2;Q99733;Q99733-2;C9J6D1;C9JZI7;E9PKT8;E9PNW0;E9PJJ2;E9PS34;E9PNJ7;A8MXH2 P55209;Q99733 NAP1L1;NAP1L4 Nucleosome assembly protein 1-like 1;Nucleosome assembly protein 1-like 4 0 15087900.0 5735400.0 1887500.0 7465000.0 False True 5553332.866399234 2641188.5931824646 5509692.554800372 1.0 0.47560422843786854 0.9921415998916775 22.404922442889482 -10.936163561705063 10.428263732564291 1.057462678264797 0.7338729141647731 0.2614076094723813 0.2108754988567149 0.11817053145522392 0.0007233780508127451 0.08564363286032133 0.06805977459960313 1.1583410256873436e-11 10.936163561705063 -0.3235897641000238 FYEEVHDLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYEEVHDLER 10 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2;Q99733;Q99733-2;C9J6D1;C9JZI7;E9PKT8;E9PNW0;E9PJJ2;E9PS34;E9PNJ7;A8MXH2 P55209;Q99733 NAP1L1;NAP1L4 Nucleosome assembly protein 1-like 1;Nucleosome assembly protein 1-like 4 0 20490500.0 1725800.0 9383400.0 9381300.0 False True 2363874.8979913727 8968810.361245684 7165630.153938297 1.0 3.7941137954748134 3.031306842856643 21.17272225592964 -10.106178160583482 5.72394735371677 0.9999815364472486 3.412710319165973 0.9302596131085781 0.31141463436118366 7.337593690425276e-05 1.1457493499075569e-05 0.30152821433506155 0.10050864105371851 7.831083224114305e-11 10.106178160583482 2.412728782718724 FYEQFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYEQFSK 7 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 16075200.0 1869800.0 10429000.0 3776400.0 False True 2451325.907168958 8873033.851923607 3385654.3537867106 1.0 3.6196875437795604 1.381152275136198 21.225130874581236 -6.607797689426134 2.1613183738917496 2.7527438423383037 1.3889030832019842 0.04375838733381643 1.130051349538763 0.6187441748581134 5.473571592847205 0.432195504035838 1.2554217339839786 2.467188377981595e-07 6.607797689426134 -1.3638407591363195 FYEQFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYEQFSK 7 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 12194500.0 5375300.0 2033200.0 4786000.0 False True 5204664.0437904615 2845067.36299793 3532403.0230776384 1.0 0.5466380421599546 0.6786995266855023 22.31137361123503 -10.569331074889805 9.565040466398036 1.0000294250224264 0.6126687844227329 0.919805493413272 0.05391387529367474 3.3832891028513726e-05 1.5233506413927839e-06 0.0522058290909938 0.017400628428492142 2.6956836535416726e-11 10.569331074889805 -0.38736064059969355 FYEQFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FYEQFSK 7 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 111467300.0 3944500.0 103900000.0 3622800.0 False True 5984094.881577182 85358233.2255948 2906751.992070353 1.0 14.264184461443163 0.4857463074355938 22.51270161956571 -6.65483796229784 1.9912585829483778 9.5741393911081 0.5437486558477009 0.21382998639785067 5.654656674411901 0.4968446273912734 3.781454854837833 2.2987131566493084 6.265301627531763 2.2139205816887486e-07 6.65483796229784 -9.030390735260399 FYEQFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYEQFSK 7 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 12976400.0 1869800.0 5880200.0 5226400.0 False True 2561115.5894450527 5620393.320778921 3992031.961086744 1.0 2.19450982374316 1.5587082354028952 21.288340936104127 -10.287887457027269 5.883384398341886 0.9999433533653866 1.876609029573031 0.7170816063016479 0.2595649115141343 0.00019287509148251073 2.3345179464214862e-05 0.25133873787925576 0.0837742149628352 5.153621781160745e-11 10.287887457027269 0.8766656762076445 FYEQFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYEQFSK 7 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 6820180.0 5375300.0 945950.0 498930.0 False True 4469800.116166072 940853.979593626 603253.9562083257 1.0 0.21049128711389323 0.13496217739726601 22.091778886669307 -13.999999999999998 0.33191626144178804 9.694244941249279 0.12188425171732203 0.9997188058364261 0.006559927076132108 18.98640597391256 0.18433330970926415 115.34862261189069 0.02403168100545685 1.0000000000000041e-14 13.999999999999998 -9.572360689531957 FYEQFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FYEQFSK 7 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 14424000.0 3944500.0 4698000.0 5781500.0 False True 5106233.007719302 4436552.170126091 4729326.323199557 1.0 0.8688503175274558 0.9261869397753767 22.28382794165816 -10.097604605071929 4.336918418383624 1.0000116531981862 0.8975186286432563 0.8098698908227442 0.02340757805228845 32837216.381228954 18657276.69977086 4435.582134964136 0.008566296622946903 7.987215367667046e-11 10.097604605071929 -0.10249302455492992 FYEQFSK(ub)NIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYEQFSKNIK 10 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 14717700.0 4540500.0 6144300.0 4032900.0 True False 5952639.470264548 5227594.39029382 3615614.1943084453 1.0 0.878197716560431 0.6073968047904906 22.50509808754163 -6.957923932833292 0.4637749666230185 1.007602737681295 0.46700604945286983 0.9996852546340457 0.002910984051973441 0.08045135674000718 0.02393666304307183 0.0037019529706615105 0.022362231300484856 1.1017322622872054e-07 6.957923932833292 -0.5405966882284252 FYEQFSK(ub)NIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYEQFSKNIK 10 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 22159800.0 6552600.0 7199800.0 8407400.0 True False 6344591.299711898 10074717.686461003 6205249.723406377 1.0 1.5879222491318687 0.9780377380160251 22.597095802126635 -6.654526089617982 1.992323598098722 1.3801357140277666 0.9805997233533083 0.2125595308150321 0.2506560944029978 0.49758577617198524 3.7907882086325957 0.10185236383749498 0.2777252221698727 2.215510998670097e-07 6.654526089617982 -0.39953599067445833 FYEQFSK(ub)NIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FYEQFSKNIK 10 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 106169100.0 22671000.0 35061100.0 48437000.0 True False 34393564.47210952 28804172.77137539 38863405.7193087 1.0 0.8374872803525006 1.129961558675428 25.035635305512436 -6.755863687517001 1.6279498805457726 0.9051240205737309 1.1308218142120354 0.6739658725676854 0.06831849965802594 0.2898843725648248 1.5131361696610008 0.03312701356601954 0.0799408312094596 1.75443108062982e-07 6.755863687517001 0.22569779363830456 FYEQFSK(ub)NIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYEQFSKNIK 10 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 15814980.0 4540500.0 4377700.0 6896780.0 True False 6219245.552398793 4184278.738881989 5267902.607642713 1.0 0.6727952295223482 0.8470324194887042 22.56830814906452 -10.044941810062573 4.848051558264028 1.000005625947079 0.7599138254408906 0.7168404656719274 0.07113203495094084 4.325571367443425e-06 8.52098886076184e-07 0.06887491078771928 0.0229577655605355 9.016919447657791e-11 10.044941810062573 -0.2400918005061885 FYEQFSK(ub)NIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYEQFSKNIK 10 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 24216400.0 6552600.0 11716600.0 5947200.0 True False 5448777.229399251 11653480.350236982 7190732.023254076 1.0 2.1387331248118993 1.319696460419778 22.37750107756091 -10.22901588499535 4.950046282116513 0.9998887119794062 1.7292147926166346 0.5138367235458738 0.3343703180680631 0.00041072686060770563 6.397136930222022e-05 0.3238015434035692 0.10791755611158028 5.901794930452558e-11 10.22901588499535 0.7293260806372284 FYEQFSK(ub)NIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FYEQFSKNIK 10 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 93811500.0 22671000.0 37072700.0 34067800.0 True False 29348056.412220567 35009571.65547756 27867809.96514712 1.0 1.192909375794287 0.9495623687551223 24.806761627604885 -6.695448429034785 1.8471042736658958 1.1203189203281887 0.9503447498402351 0.39602420752533296 0.08149911762588745 0.4050578847606881 2.683443464606952 0.035243651930931735 0.09114998342565925 2.0162833831161857e-07 6.695448429034785 -0.1699741704879536 FYEQMNGPVAGASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYEQMNGPVAGASR 14 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;E9PK06;E9PK72;E9PKK3;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;P29692-3;E9PL71;E9PN91 E9PI39;P29692;P29692-3 EEF1D Elongation factor 1-delta 0 37415800.0 2062800.0 19848000.0 15505000.0 False True 2704350.776183618 16886755.766898047 13900691.334462151 1.0 6.244291944526756 5.1401214135685525 21.366850862304815 -9.750089076800055 7.431174313863687 0.9999996995593918 5.6922066790477075 0.9601244373008436 0.45077573164448465 1.867737020402035e-08 0.0 0.4364617253832881 0.1454872417944296 1.777914710043089e-10 9.750089076800055 4.692206979488316 FYEQMNGPVAGASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYEQMNGPVAGASR 14 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;E9PK06;E9PK72;E9PKK3;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;P29692-3;E9PL71;E9PN91 E9PI39;P29692;P29692-3 EEF1D Elongation factor 1-delta 0 25461100.0 7654700.0 3216400.0 14590000.0 False True 7411705.738470944 4500725.293304416 10768441.309382107 1.0 0.6072455453733284 1.452896497696584 22.821374173560915 -6.780403976065177 1.5341842339232397 0.7777302114672516 1.4596937900969826 0.7688542394050673 0.16612090220878503 0.24994712418710965 1.162026177419792 0.0852791236878397 0.2011645340137441 1.6580438952688634e-07 6.780403976065177 0.681963578629731 FYEQMNGPVAGASR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FYEQMNGPVAGASR 14 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;E9PK06;E9PK72;E9PKK3;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;P29692-3;E9PL71;E9PN91 E9PI39;P29692;P29692-3 EEF1D Elongation factor 1-delta 0 120433500.0 3474000.0 113460000.0 3499500.0 False True 5270311.9834197275 93212176.53297381 2807822.2911146637 1.0 17.686272999818044 0.5327620641715337 22.329456936046277 -6.5452311117019315 2.407350908427346 9.999999999999998 0.5474971752060734 0.2651492594202147 6.839353547253278 0.5452933763816558 5.911736981235002 2.6512112618759116 8.401081108996188 2.849501489319175e-07 6.5452311117019315 -9.452502824793925 FYEQMNGPVAGASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYEQMNGPVAGASR 14 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;E9PK06;E9PK72;E9PKK3;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;P29692-3;E9PL71;E9PN91 E9PI39;P29692;P29692-3 EEF1D Elongation factor 1-delta 0 29419800.0 2062800.0 12756000.0 14601000.0 False True 2825472.905073943 12192397.741548905 11152544.517034203 1.0 4.315170646178902 3.9471426170842503 21.430060923827707 -10.147753807242959 4.8113316050779895 0.9997515348853169 4.1311566316488 0.9897449737852824 0.1502468137799834 0.00040046898890614183 7.09358271350063e-05 0.14548625706112986 0.048491950624118235 7.116168005048326e-11 10.147753807242959 3.131405096763483 FYEQMNGPVAGASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYEQMNGPVAGASR 14 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;E9PK06;E9PK72;E9PKK3;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;P29692-3;E9PL71;E9PN91 E9PI39;P29692;P29692-3 EEF1D Elongation factor 1-delta 0 10495000.0 7654700.0 1641300.0 1199000.0 False True 6365222.210707579 1632457.9911274563 1449705.356450368 1.0 0.25646520059917705 0.227754084376139 22.60177944899519 -13.25907589750918 0.4722596020586465 9.999367203492726 0.22846064072924446 0.9999094166303574 0.003402180363939387 19.539615824389593 0.2372623233159013 180.20830800973548 0.00617784875639098 5.507114454024006e-14 13.25907589750918 -9.770906562763482 FYFLEAYNAKSK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYFLEAYNAKSK 12 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 8589980.0 2359100.0 3487180.0 2743700.0 True False 2284211.6618060507 4879629.159403459 2025042.6607643354 1.0 2.1362421184494336 0.8865389729965747 21.12326491060705 -6.667393446689732 1.9464587947619771 1.7268959137231616 0.891636832902708 0.26748922760282656 0.482946931159796 0.4672130016146266 3.4100460597955924 0.19991777567810165 0.5359823399502991 2.1508323171547935e-07 6.667393446689732 -0.8352590808204536 FYFLEAYNAKSK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYFLEAYNAKSK 12 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 7917000.0 2359100.0 3273300.0 2284600.0 True False 1961696.175850161 3255666.0832008193 2762299.2972030938 1.0 1.6596178976542466 1.408117796837712 20.903670186041325 -10.259752741904544 5.018219116507056 0.9998970300070358 1.5338678472462661 0.8573059405424108 0.10267448621083601 0.00011830623827292792 1.7451937619737977e-05 0.09943317597217291 0.03313804793110492 5.498538345855969e-11 10.259752741904544 0.5339708172392303 FYFLEAYNAKSK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FYFLEAYNAKSK 12 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 15914100.0 3900100.0 4453800.0 7560200.0 True False 5048756.332464453 4205942.114795153 6184321.174202776 1.0 0.8330649842913104 1.2249197162549572 22.267496619771592 -6.790953456778376 1.4925658379064697 0.9068164610043503 1.2291951320364645 0.8043938301186208 0.07101006602203015 0.233928215120589 1.029502633437427 0.03744613370992253 0.0876083838142623 1.6182534561334938e-07 6.790953456778376 0.32237867103211415 FYGDEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYGDEEK 7 0 P27797;K7EJB9 P27797 CALR Calreticulin 0 4193970.0 1263000.0 542570.0 2388400.0 False True 1222906.7563312477 759221.0304651709 1762806.3895358613 1.0 0.6208331310089854 1.4414887974160242 20.221882975391544 -6.781065152704533 1.531590350151753 0.7856014820210024 1.4482221571230032 0.7711689778568691 0.16042048888103133 0.24893134199820965 1.1534293695264415 0.08248811443586739 0.19447534782540624 1.6555215840767356e-07 6.781065152704533 0.6626206751020007 FYGDEEKDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYGDEEKDK 9 1 P27797;K7EJB9 P27797 CALR Calreticulin 0 19687690.0 7617300.0 127390.0 11943000.0 False True 7375492.980999207 178257.49133007377 8814770.01767995 1.0 0.024168891732295302 1.1951431640418637 22.814308052241692 -6.685519686548807 1.88223256544145 0.3856845279844959 1.1909094120581736 0.34966587359941803 0.4130871862952995 0.42632551416604436 2.9247008143622195 0.17580026456630998 0.4604158228990276 2.062910153569249e-07 6.685519686548807 0.8052248840736778 FYGK(ub)NSSYVHGGLDSNGKPADAVYGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYGKNSSYVHGGLDSNGKPADAVYGQK 27 2 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 7694200.0 3896600.0 1619100.0 2178500.0 True False 3772904.565891005 2265615.073494959 1607885.496400884 1.0 0.6004962579698631 0.42616649011930874 21.847244177540823 -13.999999999999998 0.11278518685559845 2.9190877852757415 0.11881603998773552 0.9997289461348495 0.003954635556400689 11.996990301380327 0.10235376624312972 5.216850747923371 0.27283411835538196 1.0000000000000041e-14 13.999999999999998 -2.800271745288006 FYGPAGPYGIFAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYGPAGPYGIFAGR 14 0 O15173;O15173-2 O15173 PGRMC2 Membrane-associated progesterone receptor component 2 0 4386100.0 1168300.0 1377000.0 1840800.0 False True 1531652.6138332922 1171556.967503961 1650331.674200449 1.0 0.7648973121730822 1.0774843194176627 20.5466576935258 -6.705497204001875 1.811451786858066 0.8547997478048864 1.0766498388613697 0.4435660524485744 0.09914421060022614 0.3842202420808927 2.4547650706338366 0.04360425388523896 0.11137622603447471 1.9701658911504369e-07 6.705497204001875 0.22185009105648323 FYGPAGPYGIFAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYGPAGPYGIFAGR 14 0 O15173;O15173-2 O15173 PGRMC2 Membrane-associated progesterone receptor component 2 0 3786160.0 1168300.0 937560.0 1680300.0 False True 1600252.0821203613 896135.4991036837 1283447.7468647745 1.0 0.5599964587556037 0.8020284811404116 20.60986775504869 -10.103910998571822 5.255157564673894 1.0000062328232497 0.6810124699476806 0.698432782714351 0.09880915937725297 7.2156987333609866e-06 1.2303012594925894e-06 0.09567342563086258 0.03189051905990642 7.872070981628334e-11 10.103910998571822 -0.31899376287556913 FYK(ub)NWHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYKNWHK 7 1 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2 P39023 RPL3 60S ribosomal protein L3 1 1341280.0 291730.0 323310.0 726240.0 True False 399590.46470681607 309025.0951568034 554717.0693822975 1.0 0.7733545278252285 1.388213980004001 18.6081626314302 -6.806926249308176 1.4274932362023205 0.8760249212297367 1.3982230071120065 0.8516317333978469 0.09779396886550036 0.2110213761078856 0.8480729624591593 0.05387777162205568 0.1248083751120246 1.5598173642226013e-07 6.806926249308176 0.5221980858822698 FYLPGTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYLPGTSR 8 0 Q96SB8;Q96SB8-2;C9JMN1 Q96SB8 SMC6 Structural maintenance of chromosomes protein 6 0 9076000.0 3366100.0 3029600.0 2680300.0 False True 4610638.135432131 2895742.2544525373 2047268.342511251 1.0 0.6280567178324297 0.4440314512601348 22.136535010024378 -13.999999999995259 0.09212211905538344 2.8885917447657476 7.533611260002069e-12 0.9998340106951532 0.002979405275180136 12.10271130437263 0.08839188316296769 4.444589151630692 0.3969202279066452 1.0000000000109167e-14 13.999999999995259 -2.888591744758214 FYNELTEILVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYNELTEILVR 11 0 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 8572200.0 2421900.0 2821300.0 3329000.0 False True 2345018.1101810345 3947859.802885141 2457035.0321407127 1.0 1.6835093024421752 1.047768041309937 21.16116763379936 -10.295278176523444 4.389852662862031 0.9997052680970843 1.3656386718797662 0.3060587927767361 0.25954028304711935 0.0007492549106915827 0.00012028112138869611 0.25149908276224303 0.08376626615753507 5.066660719723747e-11 10.295278176523444 0.3659334037826819 FYNLVLLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYNLVLLPR 9 0 Q13895;H7BY94 Q13895 BYSL Bystin 0 14273700.0 4002100.0 6821900.0 3449700.0 False True 5246791.856391532 5804099.1115579335 3092758.135859022 1.0 1.106218670460026 0.5894569901970647 22.323004127799663 -6.853130034553651 1.2199027454978941 1.0568706316795773 0.5675182154563799 0.9447388438264578 0.05238170365538699 0.154044271193941 0.43957119140488743 0.03357121186503016 0.07785687010807786 1.4023937430947643e-07 6.853130034553651 -0.48935241622319736 FYNLVLLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYNLVLLPR 9 0 Q13895;H7BY94 Q13895 BYSL Bystin 0 10228600.0 5910300.0 2718900.0 1599400.0 False True 5722680.761634655 3804570.9488761947 1180469.1590284936 1.0 0.6648232021576961 0.20627905140934305 22.448259698061044 -7.348823823102623 0.4170294431014984 1.0283552685945128 1.300741513239636e-22 0.999222009408626 0.009074462888704385 0.10710572132052631 0.0386645361002939 0.013724895606125997 0.05659895254275832 4.4789496142727226e-08 7.348823823102623 -1.0283552685945128 down FYNLVLLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYNLVLLPR 9 0 Q13895;H7BY94 Q13895 BYSL Bystin 0 20491100.0 4002100.0 8353100.0 8135900.0 False True 5481784.522685874 7984032.421992185 6214367.984120175 1.0 1.456465935308289 1.1336395946251754 22.386214189322555 -10.343439742310734 9.275177699972357 0.9999997600183247 1.2950527649667323 0.526914312890231 0.13179330170058573 6.53911054428801e-07 4.633252838857285e-08 0.1276084202369016 0.04253610521900483 4.534822133715939e-11 10.343439742310734 0.2950530049484076 FYNLVLLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYNLVLLPR 9 0 Q13895;H7BY94 Q13895 BYSL Bystin 0 14237700.0 5910300.0 4122900.0 4204500.0 False True 4914676.320684675 4100689.1193684204 5083641.510588464 1.0 0.8343762339158775 1.0343797188011459 22.22866497349532 -6.686809726971798 1.8776027102100414 0.8958554480502297 1.033665553459277 0.35556531514391576 0.07009328876679985 0.4235838166546679 2.892642802190248 0.029891533519554533 0.07815840100661847 2.0567915197815774e-07 6.686809726971798 0.13781010540904726 FYPPKVELFFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYPPKVELFFK 11 1 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 2128740.0 647280.0 800320.0 681140.0 False True 848590.3482684373 680915.3756229262 610662.1667562445 1.0 0.8024076363964606 0.7196195054566797 19.694708744174996 -13.999999999898376 0.11919761902311653 1.9423406114147703 0.586044741795566 0.999696886081102 0.0020477729143799934 11.966866327970184 0.1061492284175738 2.6742110649736324 0.11852708402026241 1.000000000233997e-14 13.999999999898376 -1.3562958696192045 FYPPKVELFFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FYPPKVELFFK 11 1 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 18984500.0 5027500.0 6614600.0 7342400.0 False True 7627085.059482639 5434172.949894316 5891171.421711762 1.0 0.7124835907183297 0.7724014319713609 22.8627003585286 -10.775598334373278 7.020856918913547 1.0068451376464278 0.7424425113449605 0.9609927484892522 0.02446135625983513 0.002658099520250217 8.495846718077114e-05 0.02402053606176073 0.007894868784999 1.6764926958255865e-11 10.775598334373278 -0.26440262630146727 FYPPKVELFFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYPPKVELFFK 11 1 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 2491580.0 647280.0 805100.0 1039200.0 False True 886596.9080842844 769528.0198903288 793762.3629958181 1.0 0.867957030837258 0.8952911472598538 19.757918805697887 -10.229975472833477 5.396866390978896 1.0000082707299962 0.8816240890485438 0.9615482701823614 0.011159106300909565 1.1105700721619657e-06 1.584639491982947e-07 0.010805512932572505 0.003601586071825303 5.888769117630077e-11 10.229975472833477 -0.11838418168145237 FYPPKVELFFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FYPPKVELFFK 11 1 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 16439500.0 5027500.0 5833100.0 5578900.0 False True 6508197.856840861 5508482.857293001 4563597.444348012 1.0 0.8463914248554929 0.7012075454269032 22.63382668062105 -6.971807997509469 0.21057026271791224 1.0754613682688732 0.46808201171855823 0.9999932588626502 0.00031669847383304016 0.07572028767191114 0.006889997711142208 0.004327969080301388 0.015024792051618698 1.0670677698367209e-07 6.971807997509469 -0.6073793565503149 FYQASTSELYGK(ub)VQEIPQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYQASTSELYGKVQEIPQK 19 1 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 1 9367100.0 2290600.0 4622500.0 2454000.0 True False 3002998.782201958 3932841.0183638777 2200083.620430194 1.0 1.3096378998462697 0.7326288753327352 21.517972459167105 -6.760950415512318 1.6088425674579454 1.1796482767411498 0.7304205651296445 0.6947967924103291 0.13025354989669005 0.281354593381361 1.4355152131200641 0.06387116818531818 0.15335184147119132 1.7340019617956611e-07 6.760950415512318 -0.4492277116115053 FYQASTSELYGK(ub)VQEIPQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYQASTSELYGKVQEIPQK 19 1 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 1 17743900.0 5710600.0 5622000.0 6411300.0 True False 5529320.128824397 7866893.918342699 4731988.195122783 1.0 1.4227597127777987 0.8557992818058924 22.398670670566755 -6.707074625643462 1.805644922517847 1.2606752326794686 0.8572429292318637 0.4512092351537301 0.17823208835411894 0.38097747552443095 2.4194392133672857 0.078606342724452 0.20040773681076976 1.9630229379043234e-07 6.707074625643462 -0.40343230344760483 FYQASTSELYGK(ub)VQEIPQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYQASTSELYGKVQEIPQK 19 1 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 1 17691700.0 5710600.0 7486900.0 4494200.0 True False 4748616.922474643 7446566.583666701 5433916.441167014 1.0 1.5681548343946172 1.1443156038653968 22.17907594600103 -10.444904066452418 5.768058632178227 0.9997761737789497 1.3562352191300073 0.4850434964543463 0.1730316412950746 0.0004983527359111854 4.795934230867816e-05 0.16764093829659565 0.05584572209189643 3.590012275193423e-11 10.444904066452418 0.35645904535105766 FYQK(ub)LLELEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYQKLLELEK 10 1 P56937-3;P56937-2;P56937 P56937-3 HSD17B7 3-keto-steroid reductase 1 2779430.0 0.0 981330.0 1798100.0 True False 0.0 976043.380511245 2174074.3965249425 0.0 FYSFLVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYSFLVLK 8 0 O60216;E5RI01;E5RFZ5;Q9H4I0;E5RG18 O60216 RAD21;RAD21L1 Double-strand-break repair protein rad21 homolog;Double-strand-break repair protein rad21-like protein 1 0 13291600.0 4340000.0 5455700.0 3495900.0 False True 5689782.028619787 4641730.826152036 3134177.803040714 1.0 0.8158011682704154 0.550843211088878 22.4399419543248 -6.965944378776991 0.341456864826274 1.028257794342805 0.32956182962377323 0.9999313082911011 0.0015279139953786175 0.07764193531599056 0.013738053616645393 0.0037238269183693775 0.02290896134684263 1.0815724622242175e-07 6.965944378776991 -0.6986959647190318 FYSFLVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYSFLVLK 8 0 O60216;E5RI01;E5RFZ5;Q9H4I0;E5RG18 O60216 RAD21;RAD21L1 Double-strand-break repair protein rad21 homolog;Double-strand-break repair protein rad21-like protein 1 0 12254500.0 5980800.0 3566700.0 2707000.0 False True 5790942.777724408 4990901.910094783 1997955.4917407383 1.0 0.8618461797434637 0.34501385498508574 22.465366810461788 -6.946414195692818 0.5969159179081965 1.0058630996524354 0.17467992966424073 0.9988889822519453 0.009396273320510934 0.08495841344301096 0.04217371541573218 0.009673346775145707 0.04339017527276416 1.1313208842662678e-07 6.946414195692818 -0.8311831699881946 down FYSFLVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 FYSFLVLK 8 0 O60216;E5RI01;E5RFZ5;Q9H4I0;E5RG18 O60216 RAD21;RAD21L1 Double-strand-break repair protein rad21 homolog;Double-strand-break repair protein rad21-like protein 1 0 52851000.0 11392000.0 21195000.0 20264000.0 False True 17282496.86675807 17412586.652709153 16258811.517973267 1.0 1.0075272564464515 0.9407675084985083 24.042808328302282 -6.87888721812885 1.0860393643110966 1.0045994939462617 0.9361370803168847 0.9727743119994342 0.004926171521375933 0.12861796157149769 0.27831059807882186 0.003497660402165356 0.008434478494361014 1.3216388058157532e-07 6.87888721812885 -0.068462413629377 FYSFLVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYSFLVLK 8 0 O60216;E5RI01;E5RFZ5;Q9H4I0;E5RG18 O60216 RAD21;RAD21L1 Double-strand-break repair protein rad21 homolog;Double-strand-break repair protein rad21-like protein 1 0 17603800.0 4340000.0 5955900.0 7307900.0 False True 5944615.284090026 5692748.644472494 5581924.530924895 1.0 0.9576311287474532 0.9389883557080935 22.503152015847693 -13.999999999076287 0.11145516119528673 1.2039383116887985 0.9054943263700569 0.9997356277858184 0.00041503255893302396 12.004252261648892 0.10154147062731382 0.5494471166821444 0.029739710585283397 1.000000002126927e-14 13.999999999076287 -0.2984439853187416 FYSFLVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYSFLVLK 8 0 O60216;E5RI01;E5RFZ5;Q9H4I0;E5RG18 O60216 RAD21;RAD21L1 Double-strand-break repair protein rad21 homolog;Double-strand-break repair protein rad21-like protein 1 0 11604000.0 5980800.0 2992300.0 2630900.0 False True 4973300.194364232 2976179.885974951 3181009.0260928078 1.0 0.5984315785617712 0.6396173369340429 22.245772085896064 -10.065484066440685 7.599651085945455 1.000000030123312 0.6190244581467153 0.9913109725215662 0.016814015446937693 8.568054058453582e-09 1.0853317816906996e-09 0.016280101665173467 0.005426700150738659 8.600346195836741e-11 10.065484066440685 -0.3809755719765968 FYSFLVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FYSFLVLK 8 0 O60216;E5RI01;E5RFZ5;Q9H4I0;E5RG18 O60216 RAD21;RAD21L1 Double-strand-break repair protein rad21 homolog;Double-strand-break repair protein rad21-like protein 1 0 52722000.0 11392000.0 20883000.0 20447000.0 False True 14747168.569891809 19720842.692367636 16725855.803936943 1.0 1.337262987054356 1.1341740432861718 23.81393465039473 -10.20016368941934 4.039860016417975 0.9998655119756641 1.2357185152098447 0.6423711933813481 0.08291071426086699 58746134.86347473 49356542.39654587 86954.3902680063 0.03034221969093395 6.307195759053525e-11 10.20016368941934 0.23585300323418057 FYSQAIELNPSNAIYYGNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYSQAIELNPSNAIYYGNR 19 0 P53041;H0YDU8 P53041 PPP5C Serine/threonine-protein phosphatase 5;Serine/threonine-protein phosphatase 0 6876000.0 2066200.0 3340900.0 1468900.0 False True 2708808.20910926 2842450.7427262003 1316912.3186837467 1.0 1.0493362849269001 0.4861593058730387 21.369226819799454 -6.885555352492558 1.0482972327197424 1.033562174272446 0.44173388140610104 0.9778984105539927 0.03785829258236679 0.1228243491755241 0.24349666271595077 0.02766464000518338 0.06795355997327673 1.30150142367403e-07 6.885555352492558 -0.5918282928663449 down FYSQAIELNPSNAIYYGNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYSQAIELNPSNAIYYGNR 19 0 P53041;H0YDU8 P53041 PPP5C Serine/threonine-protein phosphatase 5;Serine/threonine-protein phosphatase 0 10075100.0 4147500.0 2145600.0 3782000.0 False True 4015839.8827267243 3002349.269156185 2791380.7424320113 1.0 0.7476267373283849 0.6950926391359721 21.93727031744722 -13.999999999999979 0.22059995217091657 2.526946643589635 0.667153068913392 0.9994984990266326 0.0029804787677084293 13.015944603288725 0.148786342687872 8.66067741172352 0.028958895401355968 1.000000000000049e-14 13.999999999999979 -1.859793574676243 FYSQAIELNPSNAIYYGNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYSQAIELNPSNAIYYGNR 19 0 P53041;H0YDU8 P53041 PPP5C Serine/threonine-protein phosphatase 5;Serine/threonine-protein phosphatase 0 9198400.0 2066200.0 3102000.0 4030200.0 False True 2830129.9769554827 2964943.3830577577 3078349.7645744346 1.0 1.0476350581775402 1.0877061441135558 21.432436881322346 -6.973122497885599 0.16758076911795794 0.9634215684779246 1.1729902840600857 0.9999975936526051 5.531184545730739e-05 0.07530175089690834 0.0052137959762784125 0.0017268471736158746 0.004680732180628309 1.0638429064505196e-07 6.973122497885599 0.20956871558216106 FYSQAIELNPSNAIYYGNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYSQAIELNPSNAIYYGNR 19 0 P53041;H0YDU8 P53041 PPP5C Serine/threonine-protein phosphatase 5;Serine/threonine-protein phosphatase 0 8627700.0 4147500.0 2513400.0 1966800.0 False True 3448830.0154035687 2499859.815329163 2378048.786544274 1.0 0.7248428609598027 0.6895233386171988 21.717675592881495 -13.999999999999998 0.2894280716622458 3.363397959886821 0.6798430689850696 0.9996261810846622 0.0026833428047336456 15.93171765904342 0.17059211699696536 22.41157564341941 0.013373734990935615 1.0000000000000041e-14 13.999999999999998 -2.6835548909017515 FYSVNVDYSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYSVNVDYSK 10 0 O00483 O00483 NDUFA4 Cytochrome c oxidase subunit NDUFA4 0 33937000.0 11021000.0 11655000.0 11261000.0 False True 14448637.727515815 9916119.430834183 10095819.743139531 1.0 0.6863013398107451 0.6987385200968235 23.784430140577324 -9.95990311416549 6.10118267057238 1.0000001386742652 0.6925199299537455 0.9987744270812401 0.005077457590120709 9.58021086406474e-09 1.6269631455514708e-09 0.004916229406177227 0.0016387423906140356 1.0967228344244291e-10 9.95990311416549 -0.30748020872051973 FYSVNVDYSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYSVNVDYSK 10 0 O00483 O00483 NDUFA4 Cytochrome c oxidase subunit NDUFA4 0 24023700.0 11021000.0 6086200.0 6916500.0 False True 15095761.5313263 5817291.559628024 5282965.149788859 1.0 0.38535926442373536 0.3499634741066755 23.847640202100216 -13.794817756937892 0.40796379129816424 9.999960468645975 0.3482387686370338 0.999845444043654 0.0037101844363813348 23.468585241427128 0.21116455432333742 186.33184268696792 0.008865983768191239 1.60391830198389e-14 13.794817756937892 -9.651721700008942 FYTLIPHDFGMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 FYTLIPHDFGMK 12 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 174375800.0 49116500.0 52330100.0 72929200.0 False True 64392207.144862585 44522653.06113216 65383185.97028431 1.0 0.6914292122487732 1.0153897322263288 25.940382765692114 -11.04268872097288 11.873674533858797 1.4709533537914212 0.8534094722314144 0.21445549276201092 0.1322563284586212 0.04297008050258691 0.0001544879771579588 0.0033372440100354413 0.042685546462564825 9.06382014226924e-12 11.04268872097288 -0.6175438815600068 FYTLIPHDFGMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 FYTLIPHDFGMK 12 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 122721700.0 49405400.0 17807200.0 55509100.0 False True 47837052.620148696 24917707.82332123 40969601.47269512 1.0 0.5208871880377102 0.8564407552031948 25.511625167851093 -10.149596689339756 5.791151233016834 1.0000037018191679 0.6886639716204409 0.5344116302054076 0.1369891701544054 6.547523589208576e-06 9.614445773334123e-07 0.13264077056792017 0.04421306455155893 7.086035286353892e-11 10.149596689339756 -0.31133973019872696 FYTLIPHDFGMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 FYTLIPHDFGMK 12 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 154761800.0 49116500.0 42035800.0 63609500.0 False True 67276197.37350406 40178519.36219836 48586246.17877461 1.0 0.5972174547728257 0.7221907312780097 26.003592827215005 -10.717828377025715 10.101766485318258 1.000480203013832 0.6597040930254184 0.908138368366555 0.05102012648690901 0.0005524895650224888 1.5432676518165985e-05 0.04946356422915695 0.016466675017099554 1.9150125434709304e-11 10.717828377025715 -0.34077610998841357 FYTLIPHDFGMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 FYTLIPHDFGMK 12 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 97280200.0 49405400.0 23942600.0 23932200.0 False True 41082779.130324125 23813616.461565968 28936312.370009597 1.0 0.5796495993132218 0.7043416483149031 25.29203044328537 -10.57070420996017 9.500617658843014 1.0000298753616812 0.6419956238140642 0.9166042378454913 0.05090531583937263 3.221563064266065e-05 1.4556952557450442e-06 0.04929295224458087 0.01642962003994324 2.6871740076862262e-11 10.57070420996017 -0.35803425154761703 FYTLIPHDFGMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 FYTLIPHDFGMK 12 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 49457400.0 11606500.0 22119300.0 15731600.0 False True 15024843.048318934 20888341.510572616 12868610.21984712 1.0 1.3902535582832412 0.8564888284331819 23.840846584625893 -6.710650781993876 1.7924470760301183 1.239747309944599 0.8576924528826317 0.46844926363794837 0.16443266367733253 0.3737395193312793 2.341012369395748 0.07298523663919532 0.1853010210370192 1.946924982873875e-07 6.710650781993876 -0.3820548570619673 FYVEDLK(ub)AR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYVEDLKAR 9 1 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 5488770.0 1843200.0 2662900.0 982670.0 True False 2416453.0495741884 2265605.699902901 880992.7348362425 1.0 0.9375748890722835 0.364580944368642 21.204459533547908 -6.927632781763112 0.7659768658487945 1.0095214190840889 0.2537399381444292 0.9960521249614631 0.017967694122988997 0.0938858454857354 0.08384035860336206 0.016144555115110426 0.052537142024072836 1.1813190792847378e-07 6.927632781763112 -0.7557814809396597 down FYVEDLK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FYVEDLKAR 9 1 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 21905100.0 4318300.0 5224800.0 12362000.0 True False 5590124.476418866 4934035.287031681 10112242.844831433 1.0 0.882634243270467 1.8089477054560184 22.414448977529098 -6.875102549366157 1.106689539120413 0.9310517574558104 1.8687433988236328 0.9695184988041693 0.07189630838066206 0.13205957631690476 0.29922057488249965 0.05024333059015 0.12013164116344836 1.3332065867321986e-07 6.875102549366157 0.9376916413678225 FYVHIKPAPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYVHIKPAPAR 11 1 O14526;O14526-2;M0QZI3;A0A0C3SFZ9;O14526-3 O14526 FCHO1 F-BAR domain only protein 1 0 8107000.0 2355400.0 2439300.0 3312300.0 False True 3087952.2097260486 2075365.9483169275 2969574.9698251574 1.0 0.6720848663979311 0.961664808306281 21.55821899442863 -10.237334902883063 7.53363018285693 1.0000003289360313 0.8168748380970741 0.3477733867927625 0.11822051623670861 6.531295208927082e-07 6.6111758515665e-08 0.1144667273198514 0.038155507547068 5.7898204663674553e-11 10.237334902883063 -0.18312549083895724 FYVHIKPAPAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYVHIKPAPAR 11 1 O14526;O14526-2;M0QZI3;A0A0C3SFZ9;O14526-3 O14526 FCHO1 F-BAR domain only protein 1 0 5777760.0 2461000.0 747360.0 2569400.0 False True 2382876.902083294 1045784.7454309146 1896397.059652251 1.0 0.4388748510326359 0.7958434856598237 21.18427299406215 -10.188967739015169 7.147635045843776 1.0000006107010964 0.6173591683462453 0.6050566557267474 0.1457318348357688 1.418331430093778e-06 1.6091129339001696e-07 0.1411044672986222 0.0470347474442652 6.471906896579383e-11 10.188967739015169 -0.3826414423548511 FYVHIKPAPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYVHIKPAPAR 11 1 O14526;O14526-2;M0QZI3;A0A0C3SFZ9;O14526-3 O14526 FCHO1 F-BAR domain only protein 1 0 6192400.0 2355400.0 1881300.0 1955700.0 False True 3226255.032291625 1798177.9453728404 1493803.9389058137 1.0 0.5573576569040128 0.46301483421313944 21.62142905595152 -13.999999999999998 0.21725866564215202 3.6394437111187607 0.4112057169664666 0.9994952988380551 0.00525897314680086 12.926513920043993 0.1476825450298269 14.617004311852417 0.05317210517550909 1.0000000000000041e-14 13.999999999999998 -3.2282379941522943 FYVHIKPAPAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYVHIKPAPAR 11 1 O14526;O14526-2;M0QZI3;A0A0C3SFZ9;O14526-3 O14526 FCHO1 F-BAR domain only protein 1 0 5258200.0 2461000.0 1639800.0 1157400.0 False True 2046430.540785576 1630966.0719251833 1399406.9887870364 1.0 0.7969809086699293 0.6838282369700354 20.964678269496428 -13.999999999999822 0.06918729795874858 2.1829461586489405 0.26621378056389106 0.9999271445585856 0.0011164594402489555 12.368654580238163 0.07071400483800869 2.373563577947073 0.3851587555586612 1.000000000000409e-14 13.999999999999822 -1.9167323780850494 FYVHIKPAPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FYVHIKPAPAR 11 1 O14526;O14526-2;M0QZI3;A0A0C3SFZ9;O14526-3 O14526 FCHO1 F-BAR domain only protein 1 0 8852200.0 2007900.0 3886500.0 2957800.0 False True 2599266.1316262083 3670212.8584919292 2419510.7495908774 1.0 1.4120188824973041 0.9308437947741548 21.309672924227424 -6.68003338653305 1.9019366446961101 1.2606878288069192 0.932683700493896 0.32415963968743455 0.17462327067211672 0.4384743905016417 3.0666868809963743 0.07367397127513739 0.194289885957479 2.0891355216911228e-07 6.68003338653305 -0.32800412831302317 FYVHNDIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 FYVHNDIFR 9 0 Q13283;E5RIZ6 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 11406400.0 4590000.0 5115700.0 1700700.0 False True 6017534.449623223 4352457.500842414 1524727.8782663532 1.0 0.7232958177937702 0.25338083080884083 22.52074106529413 -7.099681377448827 0.42214565373670504 1.0221027175801713 2.413707576276411e-12 0.9997690517329728 0.004683542866438362 0.07630131309950353 0.021726067481390002 0.0069661791369465265 0.0381606288192918 7.949112118576341e-08 7.099681377448827 -1.0221027175777577 down FYVHNDIFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 FYVHNDIFR 9 0 Q13283;E5RIZ6 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 6087900.0 3258400.0 1574300.0 1255200.0 False True 3154963.875557986 2202926.199866044 926425.4648071557 1.0 0.6982413386512817 0.293640593473771 21.589192055720044 -7.130671373905897 0.35065163039569053 1.0436123134447164 7.775077736362921e-17 0.9998887136712128 0.0030528058820385034 0.07967502098260516 0.01707265451925321 0.007173318751491605 0.036817296089749936 7.401651384323017e-08 7.130671373905897 -1.0436123134447164 down FYVHNDIFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 FYVHNDIFR 9 0 Q13283;E5RIZ6 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 26301800.0 6249900.0 14398000.0 5653900.0 False True 9481555.228893196 11828564.407912552 4536404.186807596 1.0 1.2475341990169821 0.47844515770828255 23.176692288467375 -6.820064376317731 1.371444321625951 1.1334117940940274 0.46160991306598115 0.8845721772546195 0.10890697541605157 0.19339061910662153 0.7146893098995694 0.06240056954612947 0.14383147383733544 1.5133369069292902e-07 6.820064376317731 -0.6718018810280462 down FYVHNDIFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 FYVHNDIFR 9 0 Q13283;E5RIZ6 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 18009400.0 4590000.0 5261400.0 8158000.0 False True 6287047.040085988 5028933.950876875 6231248.419283963 1.0 0.7998880744509419 0.9911248284852562 22.58395112681702 -10.610853926147682 8.055724858807496 1.0000766012359366 0.8955064514770604 0.28473550761310995 0.07807207790836707 0.00010748685300050326 5.192378881535787e-06 0.07564822880510695 0.02519765479524281 2.4498871166281592e-11 10.610853926147682 -0.10457014975887613 FYVHNDIFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 FYVHNDIFR 9 0 Q13283;E5RIZ6 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 9622000.0 3258400.0 4208500.0 2155100.0 False True 2709503.971595173 4185827.975178158 2605721.4459434426 1.0 1.544868735775953 0.9616968542066281 21.36959733115432 -6.66148196773385 1.9680166259243075 1.3503002560194113 0.9641387539063011 0.24182855492652966 0.2319113457090474 0.48089591526874903 3.582154994828549 0.09516280598545396 0.25706730744878353 2.1803089235366914e-07 6.66148196773385 -0.3861615021131102 FYVHNDIFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 FYVHNDIFR 9 0 Q13283;E5RIZ6 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 26923400.0 6249900.0 12510000.0 8163500.0 False True 8090618.75394723 11813807.502826182 6677826.7645835215 1.0 1.4601859093981524 0.8253789935813699 22.947818610559825 -6.712257610808797 1.7870244159162376 1.2822585648280858 0.826762216093086 0.47583832603339515 0.19385328184657943 0.37057736371329264 2.308217443641602 0.08627844311625653 0.2186007383649129 1.939734942132685e-07 6.712257610808797 -0.4554963487349998 GAAAAATGQPGTAPAGTPGAPPLAGMAIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAAAAATGQPGTAPAGTPGAPPLAGMAIVK 30 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 11544400.0 1620700.0 5384900.0 4538800.0 False True 2124753.3948811246 4581493.910175804 4069168.515243911 1.0 2.1562473655593943 1.9151250799491357 21.018863976867472 -10.102328664722352 4.4902188465856865 0.9999252137126049 2.0356862224380805 0.9609362306541425 0.09843776184416411 7563253.254140422 8508108.698100235 5848.357947872018 0.033697863707740985 7.900804857805603e-11 10.102328664722352 1.0357610087254756 GAAAAATGQPGTAPAGTPGAPPLAGMAIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAAAAATGQPGTAPAGTPGAPPLAGMAIVK 30 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 9767500.0 1620700.0 3651700.0 4495100.0 False True 2219916.5877706674 3490355.8194429427 3433449.959490479 1.0 1.5722914269261365 1.546657193520272 21.082074038390363 -10.21651278543606 5.341792508111545 0.9999634786239585 1.559474310223295 0.9984279784046451 0.01046513196562592 4.552154943448624e-06 6.676437524532495e-07 0.01013347990187623 0.0033776068181799977 6.074173805032963e-11 10.21651278543606 0.5595108315993366 GAAVDGGK(ub)LDVGNAEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAAVDGGKLDVGNAEVK 17 1 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 74798900.0 26539100.0 24900000.0 23359800.0 True False 34793017.10500995 21185017.059439816 20942751.97902415 1.0 0.6088870360250914 0.6019239985947795 25.05229445307746 GAAVDGGK(ub)LDVGNAEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAAVDGGKLDVGNAEVK 17 1 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 51884840.0 17009000.0 11738640.0 23137200.0 True False 16469058.605255881 16425940.168198915 17076873.218878374 1.0 0.9973818517445068 1.0369064576300988 23.97325475513829 -6.891062181333414 1.016055519832634 0.9979300615545802 1.040377827911266 0.9815701462446902 0.002449945790618007 0.11828647658846396 0.21683670813251124 0.0018345931453146818 0.004591610819948501 1.2851026485861333e-07 6.891062181333414 0.0424477663566859 GAAVDGGK(ub)LDVGNAEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAAVDGGKLDVGNAEVK 17 1 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 80296300.0 12054700.0 36092000.0 32149600.0 True False 18287861.216617648 29651100.611916874 25795217.468329716 1.0 1.6213542010573538 1.410510346879183 24.124383024557602 -10.11416961955446 4.724375892421663 0.9999677660907923 1.5159322739040537 0.8886868391051218 0.08607664304884474 3.055312719659578e-05 5.7287586681132725e-06 0.08334878333042778 0.027781117081775476 7.688301046963929e-11 10.11416961955446 0.5159645078132614 GAAVDGGK(ub)LDVGNAEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAAVDGGKLDVGNAEVK 17 1 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 52611210.0 26539100.0 10677610.0 15394500.0 True False 36351322.46221046 10205837.88406555 11758636.15967969 1.0 0.2807556147283273 0.3234720324660416 25.115504514600353 -10.323353278526897 5.940095480309207 1.0000667480317726 0.3021138235971834 0.9971980319318564 0.017438904516166625 1.5416809873371558e-05 1.7560999759556105e-06 0.016886747311613107 0.005628382230600562 4.7494871988758994e-11 10.323353278526897 -0.6979529244345892 GAAVDGGK(ub)LDVGNAEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAAVDGGKLDVGNAEVK 17 1 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 44319500.0 17009000.0 18606400.0 8704100.0 True False 14143737.126461538 18506163.630118772 10524087.066788692 1.0 1.3084352080819972 0.7440810708436573 23.753660030572565 -6.7583105872140505 1.6188957193908817 1.179532196773035 0.7421941933619197 0.6840138780699465 0.12969880442422152 0.28576166473507564 1.4756896798557542 0.06322464261212482 0.15218930646100792 1.7445740684555858e-07 6.7583105872140505 -0.4373380034111153 GAAVK(ub)AMDEMNGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAAVKAMDEMNGK 13 1 O43390;O43390-3;B4DT28;A0A286YEZ8;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 10494200.0 4193000.0 3336800.0 2964400.0 True False 5497063.605069758 2838962.4467445267 2657672.324532707 1.0 0.5164507181845679 0.48347127038545173 22.39022974183935 -13.999999999999998 0.38143352415036597 8.23977674770529 0.4806462423123192 0.9998098196760808 0.0032560195802063658 24.217063138611795 0.20155302026315802 144.05339689750656 0.00890050867366878 1.0000000000000041e-14 13.999999999999998 -7.759130505392971 GAAVK(ub)AMDEMNGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAAVKAMDEMNGK 13 1 O43390;O43390-3;B4DT28;A0A286YEZ8;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 9785300.0 3007400.0 3091000.0 3686900.0 True False 2911931.733167529 4325252.4193520555 2721190.285370862 1.0 1.4853550205475285 0.9344965935759822 21.473545102959985 -6.674084210995513 1.9228799740875837 1.3087128136979964 0.9366808786884696 0.29718787655431345 0.2059777443077848 0.4518571765787085 3.2247727411859883 0.08611821278084306 0.22886916669758747 2.1179504185263296e-07 6.674084210995513 -0.3720319350095268 GAAVK(ub)AMDEMNGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAAVKAMDEMNGK 13 1 O43390;O43390-3;B4DT28;A0A286YEZ8;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 26512700.0 6261200.0 8371700.0 11879800.0 True False 9498698.155033844 6877704.726609345 9531752.322898697 1.0 0.724068142218468 1.0034798629586241 23.1792983676123 -10.962312018528172 10.106155093242592 1.0566734139508784 0.8637740025699209 0.24066078013749792 0.11406935732773503 0.0756560453142349 0.0002821371020072396 0.05736701467645012 0.03681572677024174 1.090656473615945e-11 10.962312018528172 -0.19289941138095756 GAAVK(ub)AMDEMNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAAVKAMDEMNGK 13 1 O43390;O43390-3;B4DT28;A0A286YEZ8;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 11143000.0 4193000.0 4100500.0 2849500.0 True False 5743265.411564393 3919326.3514598105 2176506.7872946383 1.0 0.6824212482968353 0.37896677783898297 22.45343980336224 -7.203729518736818 0.23991197928551727 1.122624375448441 3.376115199318893e-14 0.99997150452518 0.0013535074267104466 0.0911150528379875 0.012037679481582013 0.01207864194167943 0.03870455092322361 6.255621754311418e-08 7.203729518736818 -1.1226243754484073 down GAAVK(ub)AMDEMNGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAAVKAMDEMNGK 13 1 O43390;O43390-3;B4DT28;A0A286YEZ8;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 10477470.0 3007400.0 5620600.0 1849470.0 True False 2500786.3504098067 5590320.7121982565 2236185.6260169023 1.0 2.2354251538849628 0.8941929907968571 21.25395037839426 -6.664574908742361 1.9568526720169197 1.7922080562656424 0.8997414561833735 0.2552309630481765 0.5254445908039248 0.47363431738606065 3.4912154330526852 0.216591295454641 0.5827499818916563 2.1648364479871816e-07 6.664574908742361 -0.8924666000822689 GAAVK(ub)AMDEMNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAAVKAMDEMNGK 13 1 O43390;O43390-3;B4DT28;A0A286YEZ8;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 26335900.0 6261200.0 9957800.0 10116900.0 True False 8105246.826703523 9403639.676390292 8275728.008160104 1.0 1.1601916483788115 1.0210334348973698 22.95042468970475 -10.742204001908327 2.9087467892656242 0.9838952633333294 1.0906125416830144 0.36115473401592935 0.056811103619259944 32377738.50378666 43173265.99389496 3894838.7924679755 0.022456560313660386 1.810489448465442e-11 10.742204001908327 0.10671727834968492 GACPK(ub)SYGFNAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GACPKSYGFNAAR 13 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WYT6 P52701 MSH6 DNA mismatch repair protein Msh6 1 5591500.0 1071000.0 1684600.0 2835900.0 True False 1404091.3715787525 1433264.2465193677 2542468.27187367 1.0 1.020777048795488 1.8107569944076596 20.421205391743214 -6.912543606597673 0.8782375362709819 0.9774634351939588 1.918603069273545 0.9918463314838041 0.034077674957354004 0.10276042309758147 0.12982311965980717 0.02825543950513235 0.07944301180410292 1.2230843055555185e-07 6.912543606597673 0.9411396340795861 GACPK(ub)SYGFNAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GACPKSYGFNAAR 13 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WYT6 P52701 MSH6 DNA mismatch repair protein Msh6 1 3176400.0 1085200.0 0.0 2091200.0 True False 1050750.920008448 0.0 1543451.985344744 1.0 0.0 1.46890376772864 20.002989288998496 -6.723427979413088 1.7472678482446402 0.39384392003407453 1.4670223764551535 0.5285310940530149 0.4206356753161508 0.3486918883016193 2.082286134566422 0.1910286314174446 0.4775786786049961 1.8904797101168917e-07 6.723427979413088 1.0731784564210791 GACPK(ub)SYGFNAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GACPKSYGFNAAR 13 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WYT6 P52701 MSH6 DNA mismatch repair protein Msh6 1 15597600.0 1986200.0 2865400.0 10746000.0 True False 3013210.6106701917 2354046.982527616 8622048.389860885 1.0 0.7812420991057223 2.86141578000855 21.52287008405887 -6.880920229936899 1.0747042254237864 0.8627133770000641 3.011432765519517 0.9744180114648833 0.14927932693535562 0.12681574911198804 0.2674143414317348 0.10691366025540336 0.25914863718543474 1.3154664314022809e-07 6.880920229936899 2.148719388519453 up GACPK(ub)SYGFNAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GACPKSYGFNAAR 13 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WYT6 P52701 MSH6 DNA mismatch repair protein Msh6 1 6257900.0 1071000.0 1993200.0 3193700.0 True False 1466977.642686731 1905133.8333690274 2439413.836316157 1.0 1.2986795285303905 1.6628841267467682 20.484415453266106 -6.968470476698065 0.2924231710528187 0.9308681720087606 2.0419860539291514 0.9999678710132319 0.0015364327069092565 0.0768022183513971 0.010797494693512126 0.006281254277990471 0.03293619834764756 1.0752996966900648e-07 6.968470476698065 1.1111178819203908 GACPK(ub)SYGFNAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GACPKSYGFNAAR 13 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WYT6 P52701 MSH6 DNA mismatch repair protein Msh6 1 6138300.0 1085200.0 1474100.0 3579000.0 True False 902391.8825113804 1466158.7307140583 4327352.352573705 1.0 1.624747251309154 4.795424733354836 19.783394564432772 -6.939472942103464 0.6644478714977726 0.9640669710048482 5.637361935300434 0.9980940599544945 0.07254135564931974 0.08800788648067595 0.055710636882941374 0.07033475165758128 0.27353367363535147 1.149547861594759e-07 6.939472942103464 4.673294964295586 GACPK(ub)SYGFNAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GACPKSYGFNAAR 13 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WYT6 P52701 MSH6 DNA mismatch repair protein Msh6 1 15610600.0 1986200.0 1808400.0 11816000.0 True False 2571175.053855255 1707760.9502886382 9665609.242398342 1.0 0.6641947415163344 3.759218660707522 21.29399640615132 -6.88002742588097 1.079682292504003 0.7918174238401088 3.9786450353809153 0.9737059928344275 0.22485148980278594 0.1276041293364498 0.27215901775954426 0.16042524032620534 0.38796467229699316 1.3181734927120588e-07 6.88002742588097 3.1868276115408065 up GADFLVTEVENGGSLGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GADFLVTEVENGGSLGSK 18 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 191795000.0 21044000.0 81344000.0 89407000.0 False True 27588887.790385865 69207792.27642864 80156021.29250298 1.0 2.5085386842069823 2.905373420686993 24.717583961727748 -10.054278828861934 0.31989222413051965 9.027107043448525e-18 3.018298701134906 0.9988782462354788 0.027491174850006145 1.455501158976644 0.1444059904217418 1.4545184249088643 0.13054374663668786 8.825131210828506e-11 10.054278828861934 3.018298701134906 GADFLVTEVENGGSLGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GADFLVTEVENGGSLGSK 18 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 271519000.0 107400000.0 23409000.0 140710000.0 False True 103990645.78778778 32756335.77632234 103853829.79048349 1.0 0.3149930989289914 0.9986843432284911 26.63187851936413 -10.89937294220959 11.293355673792828 1.0250657741908171 0.6568387210787526 0.25144325217680685 0.2791157816903821 0.13269016465123817 0.0011823056948168725 0.2035720365123593 0.09008423117920956 1.2607444290673844e-11 10.89937294220959 -0.3682270531120645 GADFLVTEVENGGSLGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GADFLVTEVENGGSLGSK 18 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 416285300.0 7793300.0 396100000.0 12392000.0 False True 11823005.866547184 325412860.25657445 9942715.768393455 1.0 27.523699466082455 0.8409634470812579 23.495093535383077 -3.3112393140145424 17.054460035809193 9.999999999996978 12.896326477537572 0.0 12.54283319343861 0.0 0.0 3.885651906014983 0.0 0.0004883831660905951 3.3112393140145424 2.896326477540594 GADFLVTEVENGGSLGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GADFLVTEVENGGSLGSK 18 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 187125000.0 21044000.0 73888000.0 92193000.0 False True 28824535.492716674 70623383.84505843 70418912.17443575 1.0 2.4501135105161853 2.443019843016345 24.78079402325064 -10.020251909781585 4.807018388369928 0.9999723589317057 2.4465666768012118 0.9999819648424564 0.00289597776450008 239651.96517352623 249777.82687108524 58.97076169925945 0.0009913702242132776 9.544388092037696e-11 10.020251909781585 1.446594317869506 GADFLVTEVENGGSLGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GADFLVTEVENGGSLGSK 18 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 55933300.0 7793300.0 30973000.0 17167000.0 False True 10088580.478909561 29249325.322544817 14042782.14829489 1.0 2.899250829558359 1.3919482703886528 23.266219857475527 -6.5883631612954385 2.2351650105837173 2.2867497246907136 1.3962284516976848 0.0 0.8233480991896305 0.6743168878873199 6.348729525018024 0.30780818460092846 0.9180645727252037 2.5801017819621775e-07 6.5883631612954385 -0.8905212729930287 GADFLVTEVENGGSLGSKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GADFLVTEVENGGSLGSKK 19 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 214581000.0 42038000.0 30253000.0 142290000.0 True False 54419019.69286439 28569393.955475662 116394680.01869161 1.0 0.5249891327833268 2.1388602859002566 25.697607632247465 -6.827884863209656 1.3373159269687638 0.7457909810173574 2.1804482944282175 0.9015838685791158 0.21244210869183908 0.18343365159265604 0.6423286886897275 0.1247544219054802 0.2871339454918816 1.486329634262785e-07 6.827884863209656 1.43465731341086 up GADINAPDKHHITPLLSAVYEGHVSCVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GADINAPDKHHITPLLSAVYEGHVSCVK 28 1 P58546 P58546 MTPN Myotrophin 0 17540900.0 4132000.0 7921900.0 5487000.0 False True 5417092.014344921 6739983.399324344 4919257.875020564 1.0 1.2442069253164416 0.9080993754571548 22.36908716585802 -6.711860036373197 1.7887343895500127 1.1498475114607252 0.9088501548904223 0.4738784620580033 0.10287794676971906 0.37133925005244844 2.3172145615387962 0.045751468634264124 0.11596187077969701 1.9415114835275689e-07 6.711860036373197 -0.24099735657030286 GADK(ub)SSNFLYLQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GADKSSNFLYLQVK 14 1 Q9BUP3-3;Q9BUP3 Q9BUP3-3 HTATIP2 Oxidoreductase HTATIP2 1 11816000.0 5120700.0 4648900.0 2046400.0 True False 4958146.181429462 6505230.013693226 1510386.449315938 1.0 1.3120286848456193 0.3046272526157115 22.241369376471763 -6.823505577132213 1.3565820620850049 1.167608749461621 0.2809243368547771 0.8922804260785123 0.13820069505337038 0.188955369879076 0.6822978652476515 0.08003454131064316 0.18432231037349403 1.5013931250078328e-07 6.823505577132213 -0.8866844126068438 down GADK(ub)SSNFLYLQVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GADKSSNFLYLQVK 14 1 Q9BUP3-3;Q9BUP3 Q9BUP3-3 HTATIP2 Oxidoreductase HTATIP2 1 39523000.0 21871000.0 8716900.0 8935100.0 True False 33179905.984275427 7161301.089549437 7169073.568606552 1.0 0.21583247080155413 0.2160667233959044 24.983806462614663 -10.012311212502274 5.349550860583217 1.000004074226828 0.215949597097164 0.9999999328072939 9.563322673620851e-05 4.653473040660815e-09 8.590356422782709e-10 9.259695252119497e-05 3.086549040463504e-05 9.72050409360543e-11 10.012311212502274 -0.7840544771296639 GADK(ub)SSNFLYLQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GADKSSNFLYLQVK 14 1 Q9BUP3-3;Q9BUP3 Q9BUP3-3 HTATIP2 Oxidoreductase HTATIP2 1 15401700.0 5120700.0 10281000.0 0.0 True False 4258088.935473663 10225614.212381275 0.0 1.0 2.4014562324409963 0.0 22.02177465190604 -6.750371380050967 1.6607645058596083 1.8254442729965372 1.3873806832765534e-10 0.6424783064837503 0.5889300568952218 0.3011190700582135 1.636315518144003 0.28073198498460056 0.6780107231258087 1.7767593925550984e-07 6.750371380050967 -1.825444272857799 GADNLVAINLIVQHIQDILNGGPSKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GADNLVAINLIVQHIQDILNGGPSKR 26 1 Q9BZX2;A0A2R8Y653;Q9BZX2-2 Q9BZX2 UCK2 Uridine-cytidine kinase 2 0 15535100.0 7519800.0 3551700.0 4463600.0 False True 11408086.371018903 2917871.385441243 3581367.5035346164 1.0 0.2557722032026162 0.31393236227880605 23.443553473841682 -10.682517639749785 10.26951922179912 1.0003926490540818 0.2848522827407112 0.995064036072566 0.023743785515960843 0.0002135539993103446 6.602003187208494e-06 0.02300045959696896 0.0076632738232697666 2.0772193533889062e-11 10.682517639749785 -0.7155403663133706 GADPFKGDPFQNDPFAEQQTTSTDPFGGDPFK(ub)ESDPFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GADPFKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFR 38 2 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 67992000.0 24787000.0 20646000.0 22559000.0 True False 37603691.17243087 16961559.99206572 18100203.76203906 1.0 0.4510610385105247 0.48134114491689095 25.164370947784406 -9.938968261669272 5.16847408427257 1.0000015398696949 0.4662010917402694 0.99759245757967 0.01236180169680732 33870753.30276144 11.35344249401281 706.0653119973159 0.0042317735222065405 1.1508844927484423e-10 9.938968261669272 -0.5338004481294254 GADPFKGDPFQNDPFAEQQTTSTDPFGGDPFK(ub)ESDPFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GADPFKGDPFQNDPFAEQQTTSTDPFGGDPFKESDPFR 38 2 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 70376000.0 24787000.0 24091000.0 21498000.0 True False 32087260.124816403 22750314.672309026 17585584.588107627 1.0 0.7090139383609712 0.5480550386571296 24.935497269876855 -13.551986513221093 0.07410629694175001 2.5452534096580863 1.2850158770703973e-22 0.9999195099951164 0.0016779869867072567 10.549855914818375 0.07035413550363327 2.882445249437653 0.4791502236043051 2.805520760520125e-14 13.551986513221093 -2.5452534096580863 GAEAANVTGPGGVPVQGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAEAANVTGPGGVPVQGSK 19 0 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 0 42980600.0 1235600.0 25531000.0 16214000.0 False True 1619883.5655674208 21721874.319058545 14536330.815670414 1.0 13.409528178927909 8.973688680259285 20.627458687733235 -9.694950786207217 9.163790611844659 1.0000000000687466 11.191608427036828 0.8755967834117124 1.8109238921035464 0.0 0.0 1.7534195188415374 0.584473172947179 2.0185950957893878e-10 9.694950786207217 10.191608426968081 GAEAANVTGPGGVPVQGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAEAANVTGPGGVPVQGSK 19 0 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 0 39986100.0 11250000.0 3533100.0 25203000.0 False True 10892874.907938654 4943885.254873097 18601578.22620677 1.0 0.4538641356534836 1.7076830848989246 23.376881432595752 -6.788321326471393 1.5030439085775242 0.6940943121362084 1.7204052840020139 0.7958261154857617 0.2319303556934238 0.2378693751491739 1.0616415673841895 0.12146971110402141 0.284740709452018 1.628090992425546e-07 6.788321326471393 1.0263109718658054 GAEAANVTGPGGVPVQGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAEAANVTGPGGVPVQGSK 19 0 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 0 41234600.0 1235600.0 17770000.0 22229000.0 False True 1692434.7108344778 16984862.64246818 16978968.020625547 1.0 10.03575649550083 10.032273571282309 20.690668749256126 -10.000933984220753 5.334544020514698 0.9999577024578936 10.034015033413866 0.9999998885205402 0.0014218979361419366 7.153102508099643e-07 1.3392431487114324e-07 0.0013767527388966229 0.00045891557427425885 9.978517326925378e-11 10.000933984220753 9.034057330955973 GAEAANVTGPGGVPVQGSK(ub)YAADR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAEAANVTGPGGVPVQGSKYAADR 24 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 701342100.0 281202500.0 307226100.0 112913500.0 True False 368659200.66888356 261389163.43795788 101230294.16277291 1.0 0.70902655613559 0.27459044553643003 28.457712522019342 -7.114303550132992 0.3832510924540822 1.032008087819195 2.137953363527222e-14 0.9998438862631599 0.003724263643327243 0.0777274479642911 0.0189781084088699 0.006837561126658871 0.03718850837718933 7.685930443850675e-08 7.114303550132992 -1.0320080878191737 down GAEAANVTGPGGVPVQGSK(ub)YAADR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAEAANVTGPGGVPVQGSKYAADR 24 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 801608400.0 369446100.0 248036200.0 184126100.0 True False 357718235.78007114 347078348.15169555 135897950.7454022 1.0 0.9702562336382619 0.3799022167518282 28.414248425094552 -6.9173637209128 0.8440509332899983 1.014304280884677 0.290245812137006 0.9934166196133873 0.023170142109959692 0.09974804338266026 0.11383648717277411 0.0196895793144952 0.05757160523756289 1.2095846840492941e-07 6.9173637209128 -0.724058468747671 down GAEAANVTGPGGVPVQGSK(ub)YAADR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAEAANVTGPGGVPVQGSKYAADR 24 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 1499264200.0 625567200.0 661494000.0 212203000.0 True False 949031177.4882921 543445227.4237887 170260984.038121 1.0 0.5726315850466283 0.179405048092028 29.821880242413677 -7.77332071409474 0.36302860456594094 1.0657752309430748 8.713166962847894e-14 0.9987149178101457 0.012012789904666641 0.11679991349261672 0.06019178249360213 0.034335313175491926 0.07910803307434992 1.6853080138163013e-08 7.77332071409474 -1.0657752309429878 down GAEAANVTGPGGVPVQGSK(ub)YAADR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAEAANVTGPGGVPVQGSKYAADR 24 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 599561900.0 281202500.0 185499500.0 132859900.0 True False 385170663.4618259 177303518.72518465 101481127.95553151 1.0 0.46032456660022114 0.26347055365910355 28.520922583542234 -13.999956884747915 0.14025410832227925 3.578495594427312 0.02060008587277216 0.9996019315533486 0.006212041579662814 11.934001423580883 0.11735321869885922 8.420523579718223 0.2171590330636385 1.00009928146481e-14 13.999956884747915 -3.55789550855454 GAEAANVTGPGGVPVQGSK(ub)YAADR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAEAANVTGPGGVPVQGSKYAADR 24 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 866905020.0 369446100.0 393969900.0 103489020.0 True False 307210801.38729066 391847505.9517977 125128095.60283503 1.0 1.2755004191985044 0.4073036984304797 28.19465370052883 -6.821360871301632 1.3659059057904905 1.1482955559752033 0.38778107585154487 0.8874919926586219 0.12150303424920642 0.19172443374992862 0.702476534474449 0.06989430950530617 0.161045175355954 1.5088258940505204e-07 6.821360871301632 -0.7605144801236584 down GAEAANVTGPGGVPVQGSK(ub)YAADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAEAANVTGPGGVPVQGSKYAADR 24 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 1651302200.0 625567200.0 880885000.0 144850000.0 True False 809809072.1730362 831862975.3898516 118488786.28650986 1.0 1.0272334602990258 0.14631694106433982 29.593006564506126 -6.899767457052561 0.962753733008433 1.03685934585609 0.05429087452288524 0.9864497745113504 0.047609844098319164 0.11157608050339585 0.17839417778110836 0.03710591094654554 0.09642932139578438 1.2595996838138952e-07 6.899767457052561 -0.9825684713332047 down GAEEMETVIPVDVMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAEEMETVIPVDVMR 15 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 40965800.0 2536800.0 20107000.0 18322000.0 False True 3325769.366406145 17107113.976472132 16426215.197034245 1.0 5.143806467541743 4.939072252861766 21.665256694209436 -10.191026167526323 4.396397676594995 0.9988807744371992 5.041439360314707 0.9980789666991149 0.08358239354168287 14676230.258324916 348.33951032388353 166682.84718051524 0.028612476411324732 6.441304535820244e-11 10.191026167526323 4.042558585877508 GAEEMETVIPVDVMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 GAEEMETVIPVDVMR 15 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 46472400.0 16340400.0 5615100.0 24516900.0 False True 15821682.946282735 7857238.712359661 18095188.39876561 1.0 0.49661206959059306 1.1436955512382472 23.915399731096834 -6.699087643924154 1.8340285401717717 0.6871326048926205 1.1417420643929441 0.4132294099190357 0.21252295064526366 0.39745616169625697 2.5984796208819816 0.09246497432150641 0.23807205443175483 1.9994583230427587e-07 6.699087643924154 0.4546094595003236 GAEEMETVIPVDVMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAEEMETVIPVDVMR 15 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 32549800.0 2536800.0 16346000.0 13667000.0 False True 3474723.5144422976 15623779.671006473 10439136.080700405 1.0 4.496409457059817 3.00430697214075 21.728466755732327 -9.318958809698174 10.01803737573938 0.9999959768994173 3.7503582146023904 0.8191755920411438 0.6091482886695885 0.0 0.0 0.5898052943449842 0.19660176478166136 4.797789507175959e-10 9.318958809698174 2.750362237702973 GAEEWILTGSYDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAEEWILTGSYDK 13 0 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 0 7062300.0 2560500.0 2322200.0 2179600.0 False True 3356840.295917275 1975736.811864705 1954075.900199533 1.0 0.5885703928982491 0.5821176248915265 21.678672470741855 GAEEWILTGSYDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAEEWILTGSYDK 13 0 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 0 4408000.0 2560500.0 1847500.0 0.0 False True 3507186.044910719 1765871.3411344942 0.0 1.0 0.5035009031519591 0.0 21.741882532264746 -7.917893737324024 0.5950981865333748 1.010021149015955 2.5109221343633125e-18 0.9889153074641482 0.042982309309560485 0.11269991608173316 0.161098693671881 0.04470018747515121 0.07710265341843457 1.2081093977688606e-08 7.917893737324024 -1.010021149015955 down GAEEWILTGSYDK(ub)TSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAEEWILTGSYDKTSR 16 1 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 1 10315300.0 3422800.0 2886200.0 4006300.0 True False 3314145.0875459984 4038674.7113341675 2956929.84357625 1.0 1.2186173521825674 0.8922149650864402 21.660205331962377 -6.726202030409161 1.7368253098080197 1.1321162853436086 0.892531700875728 0.5416421202651143 0.09193254938164203 0.3434262712267011 2.027687811551681 0.04197451229240678 0.10461781538374298 1.878442776576966e-07 6.726202030409161 -0.23958458446788067 GAEEWILTGSYDK(ub)TSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAEEWILTGSYDKTSR 16 1 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 1 6099600.0 2308200.0 2059700.0 1731700.0 True False 3161603.9167595813 1968695.6434829338 1322708.1254810034 1.0 0.6226888931427902 0.41836617119221087 21.59222520864626 -10.582390507902085 0.11827687913192021 1.8920025234554396 8.116316111817203e-10 0.9998438733644393 0.0030103841637730317 2.500520468213075 0.06418921672547175 0.8908508834949475 0.25743376951179003 2.615829854621588e-11 10.582390507902085 -1.892002522643808 GAEEWILTGSYDK(ub)TSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAEEWILTGSYDKTSR 16 1 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 1 10187900.0 3422800.0 3593100.0 3172000.0 True False 2846209.85575005 3573743.2571254913 3835250.5343290786 1.0 1.2556148134704979 1.3474939406105004 21.440610607396653 -13.301056475200363 0.15013549558999081 2.6785773878272644e-08 1.4518266103393407 0.9995698678171282 0.0030491254601782694 9.294922857909194 0.11622180338558966 2.798620828365316 0.09064016615510263 4.99969515236487e-14 13.301056475200363 1.4518265835535669 GAEEWILTGSYDK(ub)TSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAEEWILTGSYDKTSR 16 1 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 1 18256800.0 5752700.0 3280800.0 9223300.0 True False 7446983.55266999 3098220.595945021 7544754.039049819 1.0 0.41603698652378607 1.0131288709970059 22.828224740556717 -10.831109922616141 12.060970029614607 1.0026212098042926 0.714582928760396 0.23351712969789218 0.24376174108603837 0.017247588055097362 0.00024151777986895312 0.23693417526592372 0.07867376363906256 1.4753330701013378e-11 10.831109922616141 -0.2880382810438966 GAEGK(ub)PGVEAGQEPAEAGER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAEGKPGVEAGQEPAEAGER 20 1 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 22525400.0 5985500.0 6797600.0 9742300.0 True False 5795493.578797053 9511917.129015705 7190499.367264785 1.0 1.6412609210396287 1.2407052599577357 22.46650010430213 -10.239279847858404 4.463392052542937 0.9998225709892561 1.4409830905040129 0.6177454334851304 0.1635261638905333 115398044.40813622 65.40341322552341 210430.90190034066 0.055979355438000235 5.7639493007944364e-11 10.239279847858404 0.44116051951475677 GAEGK(ub)PGVEAGQEPAEAGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAEGKPGVEAGQEPAEAGER 20 1 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 69274000.0 14976000.0 28337000.0 25961000.0 True False 22719686.892254982 23280040.952008452 20829796.9708895 1.0 1.0246638108355486 0.9168170789356374 24.43743961691929 -6.846554733056605 1.2515075279416699 1.013133049485689 0.9127818674886038 0.9351504370455567 0.011749363202835754 0.16129084787349018 0.48785902671549236 0.007352054092932436 0.016980767922128923 1.4237877988931707e-07 6.846554733056605 -0.10035118199708515 GAEGK(ub)PGVEAGQEPAEAGER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAEGKPGVEAGQEPAEAGER 20 1 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 53996000.0 14976000.0 23128000.0 15892000.0 True False 19386727.22109372 21840906.468854032 12999819.065690128 1.0 1.1265906937138952 0.6705525340835085 24.208565939011738 -6.832640763859156 1.3159676995057752 1.0675293062925515 0.6575966679001909 0.9110705558714841 0.05732156234692811 0.1775755735137961 0.6004738424018444 0.034189673516450816 0.07868415630288843 1.470141834679638e-07 6.832640763859156 -0.4099326383923606 GAEIEYAMAYSK ddPTM_RPMI8226_Bortezomib_1h_R1 2 GAEIEYAMAYSK 12 0 Q969H8;M0QYN0;M0QXF7 Q969H8 MYDGF Myeloid-derived growth factor 0 21800000.0 5886500.0 7653500.0 8260000.0 False True 7717258.504947088 6511627.633109336 7405334.435514834 1.0 0.8437747198613482 0.9595809743534836 22.879657001823926 -10.104691523351708 4.886994649895305 1.000004142687394 0.9016778473615817 0.4900872068857378 0.04727770542351689 2.134028297653096e-06 3.909938997155904e-07 0.04577837011245564 0.015258813812385306 7.857935806887392e-11 10.104691523351708 -0.09832629532581227 GAEIEYAMAYSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAEIEYAMAYSK 12 0 Q969H8;M0QYN0;M0QXF7 Q969H8 MYDGF Myeloid-derived growth factor 0 17479600.0 5898200.0 2402600.0 9178800.0 False True 5710964.869511447 3361970.7093934845 6774596.921902424 1.0 0.588686988312903 1.1862438443754544 22.445303079336487 -6.721485090564128 1.7539788360883306 0.7501606049936199 1.1853907486859334 0.5195201118228396 0.17305107804484868 0.35243679307793985 2.119770559105816 0.07831507145155187 0.19625700165793 1.8989560326077864e-07 6.721485090564128 0.4352301436923135 GAEIEYAMAYSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAEIEYAMAYSK 12 0 Q969H8;M0QYN0;M0QXF7 Q969H8 MYDGF Myeloid-derived growth factor 0 30514600.0 3121100.0 22424000.0 4969500.0 False True 4734936.882973888 18422262.000488333 3987276.146790773 1.0 3.8907090961934427 0.8420970005172426 22.174913763924387 -6.658193244612201 1.9791325211007804 2.8634788792923818 0.8548069073722606 0.227977325424207 1.2313330890432848 0.4887720287655206 3.6783704139083016 0.5029659842841211 1.3648792048657308 2.1968821258474046e-07 6.658193244612201 -2.008671971920121 GAEIEYAMAYSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAEIEYAMAYSK 12 0 Q969H8;M0QYN0;M0QXF7 Q969H8 MYDGF Myeloid-derived growth factor 0 20187900.0 4400700.0 9845900.0 5941300.0 False True 6027757.71444584 9410875.581962723 4538087.304914419 1.0 1.5612564452298843 0.7528649159269711 22.523189998338157 -6.720003392413114 1.7596269573618732 1.3414660447106896 0.7541520579033292 0.512401203027542 0.23617852418978585 0.355303554212073 2.1500679119273753 0.10658071250584239 0.2675236483672524 1.9054458338582214e-07 6.720003392413114 -0.5873139868073605 GAEIEYAMAYSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAEIEYAMAYSK 12 0 Q969H8;M0QYN0;M0QXF7 Q969H8 MYDGF Myeloid-derived growth factor 0 10924500.0 5898200.0 2199700.0 2826600.0 False True 4904614.634563784 2187849.7794937347 3417628.9912782405 1.0 0.446079853873845 0.6968190665161614 22.225708354770763 -10.382639110996832 5.963479586324708 1.0000892037244535 0.5714494601950072 0.7957064834489 0.1023638549134818 0.00012142850126724304 1.2570892457689887e-05 0.09913385661794318 0.033037792111125446 4.143438422699484e-11 10.382639110996832 -0.42863974352944634 GAEIEYAMAYSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAEIEYAMAYSK 12 0 Q969H8;M0QYN0;M0QXF7 Q969H8 MYDGF Myeloid-derived growth factor 0 17598600.0 3121100.0 9255100.0 5222400.0 False True 4040325.476078762 8740045.549113251 4271976.786349111 1.0 2.16320333618164 1.057334814148481 21.946040086016836 -6.634360637467527 2.0655357674895845 1.763906344054455 1.0619238018594983 0.133206944602692 0.49840826624240087 0.5476365959214551 4.458478764619462 0.19701543834458135 0.5517263531249325 2.3208087999195087e-07 6.634360637467527 -0.7019825421949566 GAEIIVCTPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAEIIVCTPGR 11 0 A0A0C4DG89;Q7L014;D6RJA6 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 6733000.0 1979700.0 2385300.0 2368000.0 False True 2595405.871442071 2029422.5378265772 2122982.075459944 1.0 0.7819287765959242 0.8179769102087926 21.307528735240687 -10.088904642365895 6.934299367870534 1.000000096221149 0.7999528434023946 0.9762254525258255 0.014716588921866716 2.1898350303900007e-08 2.8630066401925473e-09 0.014249282852560784 0.004749758650614157 8.14883187520313e-11 10.088904642365895 -0.20004725281875446 GAEIIVCTPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAEIIVCTPGR 11 0 A0A0C4DG89;Q7L014;D6RJA6 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 6354500.0 1979700.0 2812400.0 1562400.0 False True 2711648.5893808804 2688138.8686368875 1193393.2986380572 1.0 0.9913301005019384 0.44009880310875055 21.37073879676358 -6.910319287607024 0.8935579944318491 1.0168953638682368 0.36837283486795064 0.9910414871132667 0.02479060945885426 0.10420727000810223 0.13762495024706867 0.02032849596750564 0.056240737956321105 1.2293646257464242e-07 6.910319287607024 -0.6485225290002861 down GAEILEVLHSLPAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAEILEVLHSLPAVR 15 0 Q15008;Q15008-4;Q15008-3;Q15008-2;H7C531 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 0 766140.0 0.0 766140.0 0.0 False True 0.0 1072063.6973673205 0.0 0.0 GAELEYESLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAELEYESLKR 11 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 4031720.0 826720.0 1398600.0 1806400.0 True False 800476.226123648 1957068.27360265 1333249.6491616059 1.0 2.4448799473781566 1.665570576178063 19.610499030254125 -9.955975421144876 5.069782588759679 0.999994625135171 2.055225261793136 0.709691237245606 0.31815171858713404 109151543.1397258 3.1949403932354095 6848.571942411456 0.10891179560406275 1.106686415018329e-10 9.955975421144876 1.0552306366579651 GAELEYESLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAELEYESLKR 11 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 5016770.0 1343400.0 921270.0 2752100.0 True False 1840091.284019939 880565.245167511 2102110.66127867 1.0 0.4785443270204466 1.142394771136741 20.81134590720224 -6.697178409628045 1.8405483986972337 0.6753188574988639 1.1403456581941216 0.40441459654304523 0.2202267540170904 0.4013982987938891 2.6415063489898105 0.09552089053200588 0.24654878313567813 2.0082676400543096e-07 6.697178409628045 0.4650268006952577 GAELEYESLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAELEYESLKR 11 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 4622620.0 826720.0 2196900.0 1599000.0 True False 687454.3099058304 2185064.8636494917 1933343.5070593324 1.0 3.178487402237406 2.8123229125207865 19.3909043056884 -10.070351862264175 4.722142877851885 0.9999197456636864 2.9954051573821094 0.9753668736330576 0.14948602709289935 51874871.610007375 7.957900131372496 45857.723775065475 0.05117304314844952 8.504487315617244e-11 10.070351862264175 1.995485411718423 GAENSK(ub)GYDFEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAENSKGYDFEIK 13 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 8227200.0 1638000.0 1693600.0 4895600.0 True False 1586002.5865958708 2369863.312007328 3613295.4951481163 1.0 1.4942367257381988 2.278240606721545 20.596963693245 -6.964311396528812 0.3696869635162182 0.939495148051399 2.8602584443831467 0.9998982299350115 0.005309271560753221 0.07819549973638504 0.015689127757746796 0.010338697911790418 0.06659611421185022 1.0856469171762321e-07 6.964311396528812 1.9207632963317476 GAENSK(ub)GYDFEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAENSKGYDFEIK 13 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 26540100.0 2011100.0 5490500.0 19038500.0 True False 3050985.731104034 4510677.377527702 15275532.130128998 1.0 1.478432800108659 5.006753055053251 21.54084400203865 -6.931642942583534 0.7331808141869948 0.9494813586476393 5.762366082627378 0.9968514061620485 0.10025824157721179 0.09179368009450434 0.07356643652541932 0.09224941804133892 0.3164172191467944 1.1704612962539719e-07 6.931642942583534 4.812884723979739 up GAENSK(ub)GYDFEIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAENSKGYDFEIK 13 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 7402500.0 1638000.0 3115300.0 2649200.0 True False 1362069.5757036877 3098517.260561365 3203135.471483166 1.0 2.2748597544736833 2.351668026817445 20.377368968679278 -10.751990209911428 0.5209769956385909 7.657591787624333e-12 2.3470664855228294 0.9997576113789481 0.009650685478927324 2.327089832226743 0.2515061978649339 2.945676162416765 0.01502757633464236 1.7701488614696212e-11 10.751990209911428 2.347066485515172 GAENSK(ub)GYDFEIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAENSKGYDFEIK 13 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 24224900.0 2011100.0 5164500.0 17049300.0 True False 2603408.5947076385 4877091.035039634 13946502.340590911 1.0 1.873348288453096 5.357016324268952 21.3119703241311 -6.944938652081998 0.6118945748470425 0.9615659525388206 6.450808207988072 0.9987418278821464 0.0667610870638848 0.08558405131162906 0.04488008277654852 0.06773994329503352 0.29394895375732266 1.1351711572643656e-07 6.944938652081998 5.489242255449252 GAFGK(ub)PQGTVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAFGKPQGTVAR 12 1 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 19176600.0 4152800.0 4804800.0 10219000.0 True False 5444361.015772411 4087942.5689637084 9161635.907569751 1.0 0.7508581001738984 1.682775238642024 22.376331304497427 -6.83555617220229 1.3027458888292314 0.8672907707830688 1.7108497684880197 0.9165596226481975 0.11379470602455731 0.17405516810306243 0.5756996148711065 0.06853723459629886 0.15776869742043065 1.4603058594035853e-07 6.83555617220229 0.8435589977049509 GAFGK(ub)PQGTVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAFGKPQGTVAR 12 1 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 33545000.0 6017000.0 10238000.0 17290000.0 True False 5825993.628539288 14326086.790464677 12761230.31111834 1.0 2.45899458596843 2.190395514441693 22.474072693033847 -10.21533663997411 4.9289336064398634 0.9998202941112966 2.3246950502069446 0.9700877239210857 0.1096551117774853 0.00021657230607977215 3.447761507918175e-05 0.10618705647289878 0.03539103514412959 6.090646025485569e-11 10.21533663997411 1.324874756095648 GAFGK(ub)PQGTVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAFGKPQGTVAR 12 1 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 20077500.0 4152800.0 4010700.0 11914000.0 True False 5688202.385200247 3833494.012388698 9100158.576532118 1.0 0.6739376964439256 1.59983030846603 22.43954136602032 -6.811538396436674 1.408114683144001 0.8226231148745262 1.6165969400252966 0.8638022654693897 0.14151668161660458 0.2047035655047864 0.7996746391235662 0.0790191634548711 0.182658514650376 1.543339968965804e-07 6.811538396436674 0.7939738251507704 GAFGK(ub)PQGTVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAFGKPQGTVAR 12 1 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 27926500.0 6017000.0 15335000.0 6574500.0 True False 5003402.098296148 15252387.311240816 7949197.552946573 1.0 3.0484032687348566 1.588758488080257 22.254477968468123 -6.558237175972222 2.3536945325205005 2.4126482403494487 1.5909588872688962 0.0 0.8947626717452144 0.7671637282424771 7.962912621915427 0.3237961213684708 1.00717048080653 2.765430981704518e-07 6.558237175972222 -0.8216893530805525 GAFGK(ub)PQGTVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAFGKPQGTVAR 12 1 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 35778300.0 7340300.0 11201000.0 17237000.0 True False 9502163.048944589 10577654.503529675 14100042.866555525 1.0 1.1131838560383935 1.483877175536535 23.179824531691285 -6.949462889877672 0.5647076083302193 0.9952660448716515 1.6196548316832537 0.9991584696200174 0.005994917879670643 0.08370210107892452 0.03686021849284366 0.006390275354390418 0.030847175593472838 1.123406959815374e-07 6.949462889877672 0.6243887868116023 GAFGKPQGTVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAFGKPQGTVAR 12 1 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 0 15221000.0 1067000.0 9167500.0 4986500.0 False True 1398847.3328426986 7799744.7346351165 4470544.813885559 1.0 5.575837013453564 3.195877569284593 20.415807087817385 -9.915605739652932 8.423859042368399 0.9999999890306637 4.385857291369079 0.729626702638853 0.9716143744553082 4.806836465788792e-08 3.3282702091458827e-09 0.9407615728002839 0.31358719093342885 1.2144908868504487e-10 9.915605739652932 3.3858573023384153 GAFGKPQGTVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAFGKPQGTVAR 12 1 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 0 12574700.0 1067000.0 5946100.0 5561600.0 False True 1461498.7345907965 5683381.6408767635 4248064.624747445 1.0 3.8887352457872963 2.906649540094782 20.479017149340276 -10.4693645608324 5.823074727947491 0.9980507675241919 3.39769239294104 0.8882361035768477 0.40093481043796964 0.010147182301569952 0.0009246746385244033 0.38825167299654745 0.12940115364508978 3.39340299778166e-11 10.4693645608324 2.399641625416848 GAFHTK(ub)GYYAAVEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAFHTKGYYAAVEAK 15 1 Q15477 Q15477 SKIV2L Helicase SKI2W 1 12634000.0 1665700.0 3017100.0 7951200.0 True False 1612823.2652580822 4221843.7639686465 5868542.189113019 1.0 2.617672906208401 3.638676546604715 20.621156924553393 -8.420344370536657 0.21809217545055054 1.0909956807565955e-15 4.687231321726023 0.9996115688105383 0.021411024732462692 0.13129577695630315 0.054580896413537014 0.494053524439295 0.4432375190637528 3.798880474957195e-09 8.420344370536657 4.687231321726022 GAFHTK(ub)GYYAAVEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAFHTKGYYAAVEAK 15 1 Q15477 Q15477 SKIV2L Helicase SKI2W 1 10589600.0 1665700.0 4549500.0 4374400.0 True False 1385103.353021752 4524990.940494959 5289066.815059625 1.0 3.2668976871821185 3.8185358540364196 20.40156219998767 -9.767892607667218 0.37341984404140444 3.051448600192805e-20 3.9125864298188113 0.9986350845717245 0.04505859978679151 1.1031063160517796 0.1608670678575423 1.4645910514234548 0.15073590406382567 1.7065043211954884e-10 9.767892607667218 3.9125864298188113 GAFIQLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAFIQLLR 8 0 Q13823;H0YG10 Q13823 GNL2 Nucleolar GTP-binding protein 2 0 10508500.0 2202900.0 3386400.0 4919200.0 False True 2888023.2329139467 2881162.320083811 4410208.372298368 1.0 0.9976243567738846 1.5270681766117833 21.461650917461625 -6.905890107823674 0.9232756756954972 0.9814012116674603 1.5897985030464328 0.9892756955014606 0.025788496999150076 0.10719905477901051 0.15397696593545201 0.020693354506625194 0.05561981060176243 1.2419665301869462e-07 6.905890107823674 0.6083972913789725 GAFIQLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAFIQLLR 8 0 Q13823;H0YG10 Q13823 GNL2 Nucleolar GTP-binding protein 2 0 10994900.0 3549800.0 2370500.0 5074600.0 False True 3437113.542062277 3317053.011994197 3745410.0252632233 1.0 0.965069373298607 1.0896963336904977 21.71276607999992 -6.831901693799641 1.3195709988630575 0.9813592806610366 1.0931777768351902 0.9095911518229065 0.015782935732231065 0.17847796347461978 0.6071539032927997 0.009389578376677131 0.0216056190850896 1.4726458104446577e-07 6.831901693799641 0.11181849617415363 GAFIQLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAFIQLLR 8 0 Q13823;H0YG10 Q13823 GNL2 Nucleolar GTP-binding protein 2 0 10305600.0 2202900.0 3662000.0 4440700.0 False True 3017371.661134083 3500200.731385401 3391898.1190873142 1.0 1.1600164396287351 1.1241234093822121 21.524860978984517 -10.085877598378206 4.294455620355848 0.9999835157915199 1.1420699245217645 0.9543154611525144 0.014653268303251447 10185678.952771468 0.15644835234914328 1698.0760186872387 0.005016203484603421 8.205827849167905e-11 10.085877598378206 0.14208640873024458 GAFIQLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAFIQLLR 8 0 Q13823;H0YG10 Q13823 GNL2 Nucleolar GTP-binding protein 2 0 6569200.0 3549800.0 1251500.0 1767900.0 False True 2951815.982803993 1244757.9210966998 2137559.716153965 1.0 0.4216922492283132 0.7241507358881671 21.493171355434196 -10.115813701646077 5.902593771428342 1.0000025793789842 0.5729214925582242 0.7266575092939458 0.12347816011522905 4.191311213333727e-06 6.276494844862526e-07 0.1195579367041526 0.039852404812209655 7.659250936631351e-11 10.115813701646077 -0.42708108682075996 GAFK(ub)AFTGEGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAFKAFTGEGQK 12 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 5349560.0 2113900.0 2562800.0 672860.0 True False 2771343.3710367205 2180440.229716159 603238.9017288747 1.0 0.7867809714609587 0.21767021294918482 21.402154041962948 -7.006940486788363 0.531846943694449 1.0082221245039122 1.1327201508828038e-14 0.9994529057227893 0.007723788454473574 0.07542062661701973 0.030731791547651724 0.008781844427787268 0.042898647293196625 9.841459582087022e-08 7.006940486788363 -1.008222124503901 down GAFK(ub)AFTGEGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAFKAFTGEGQK 12 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 10158400.0 3399700.0 3726800.0 3031900.0 True False 3291778.384401697 5214930.67500526 2237754.434949661 1.0 1.5842289686682867 0.6798010599842942 21.650435780391444 -6.732328799985643 1.7148817026806293 1.350679120543397 0.6801229789359663 0.56993510664497 0.24555456104401652 0.33190554120591564 1.9132814365968474 0.11342747826752944 0.280708190888246 1.852128864333426e-07 6.732328799985643 -0.6705561416074307 GAFK(ub)AFTGEGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAFKAFTGEGQK 12 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 12628500.0 3279500.0 3906300.0 5442700.0 True False 4975241.263565054 3209190.244938792 4366947.959379848 1.0 0.6450320848640048 0.8777359183282445 22.246335057052676 -10.630944510838253 5.032442030246887 1.0033147379697078 0.7613840015961235 0.5836706216511992 0.09500094219616902 0.003576925676300825 0.0002623145308895281 0.09312491062754251 0.030661422249980554 2.3391360875153818e-11 10.630944510838253 -0.2419307363735843 GAFK(ub)AFTGEGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAFKAFTGEGQK 12 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 10461900.0 3399700.0 5175500.0 1886700.0 True False 2827001.182246536 5147618.554243685 2281200.246884829 1.0 1.8208759821433895 0.8069328945494197 21.43084105582572 -6.691314931379756 1.8616208833509387 1.5140021671600385 0.8103720604074935 0.37661499470786186 0.3470809634088534 0.4138647478841175 2.7818444353949965 0.1490887705486213 0.38761277878464895 2.035565439270549e-07 6.691314931379756 -0.703630106752545 GAFK(ub)AFTGEGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAFKAFTGEGQK 12 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 13957300.0 3279500.0 5346900.0 5330900.0 True False 4245377.398609568 5049340.314697158 4360730.899653123 1.0 1.1893737212505302 1.0271715539545045 22.017461379145125 -10.736627380465134 2.981713682709477 0.9822518838595504 1.108272637584507 0.372688556606372 0.06621875787719346 49386745.497321695 54861598.3089975 6592394.135482538 0.024233584684282355 1.8338872011155784e-11 10.736627380465134 0.12602075372495647 GAFNSK(ub)QLLYLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAFNSKQLLYLEK 13 1 A0A0D9SGK2;Q93096;Q12974-3;Q12974-4;Q12974 A0A0D9SGK2;Q12974-4 PTP4A1;PTP4A2 Protein tyrosine phosphatase type IVA 1;Protein tyrosine phosphatase type IVA 2 1 46206500.0 13731900.0 28262700.0 4211900.0 True False 18002653.879908763 24046015.327141725 3776092.991397691 1.0 1.3356928088240059 0.20975201859609535 24.101706262830977 -6.826803604834486 1.3421239690269149 1.1798057162197308 0.18138282623165447 0.8993319228599814 0.14975233756831582 0.18478782739967306 0.6520960331935981 0.08763458360419953 0.20171915734933543 1.4900347437945385e-07 6.826803604834486 -0.9984228899880764 down GAFNSK(ub)QLLYLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAFNSKQLLYLEK 13 1 A0A0D9SGK2;Q93096;Q12974-3;Q12974-4;Q12974 A0A0D9SGK2;Q12974-4 PTP4A1;PTP4A2 Protein tyrosine phosphatase type IVA 1;Protein tyrosine phosphatase type IVA 2 1 60273000.0 32446200.0 21923600.0 5903200.0 True False 31416213.141151916 30677807.81006368 4356974.827796057 1.0 0.9764960427353033 0.13868555093576446 24.905005955227637 -6.912905925169425 0.8757153114472557 1.0236176834173256 0.02340407352805751 0.991972629307217 0.035892221099165886 0.10252777097980159 0.12857725317008936 0.02981429554357154 0.08405587018197448 1.22206434933469e-07 6.912905925169425 -1.0002136098892682 down GAGALLQHGLVNFTFNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAGALLQHGLVNFTFNK 17 0 M0R259;M0QWZ7;M0R2C6;Q9NP81;Q9NP81-2 M0R259 SARS2 Serine--tRNA ligase, mitochondrial 0 8491900.0 0.0 2175800.0 6316100.0 False True 0.0 2079665.9615915734 4824367.264162716 0.0 GAGGEENKENERPSAGSK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAGGEENKENERPSAGSK 18 2 Q9UHB9-4;Q9UHB9;Q9UHB9-2;K7EQC2;K7EN53 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 1 15500600.0 6672600.0 5824200.0 3003800.0 True False 8637812.236609904 5500078.15011673 2457139.2215907373 1.0 0.636744351400182 0.2844631434770681 23.04223452580244 -7.481308416102302 0.29540501239937067 1.0905883714233662 8.642732051244184e-13 0.9997395484058589 0.004714510356319513 0.1228792725987065 0.029624226111168887 0.02206733657448029 0.06363811876918239 3.301350109663109e-08 7.481308416102302 -1.090588371422502 down GAGGEENKENERPSAGSK(ub)ANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAGGEENKENERPSAGSKANK 21 3 Q9UHB9-4;Q9UHB9;Q9UHB9-2;K7EQC2 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 1 34923800.0 13564000.0 18652000.0 2707800.0 True False 11279066.987084744 18551517.973867863 3273988.4605473755 1.0 1.6447741639543894 0.2902712134165266 23.4271443960637 -6.777275930859279 1.5465710061676512 1.3663874725328387 0.28046304003792727 0.7575774218829872 0.2723687343814037 0.25484454993843325 1.203807601085535 0.13873842761014435 0.3281059418458109 1.6700292169485536e-07 6.777275930859279 -1.0859244324949113 GAGGSFQK(ub)AQTEWNTGTWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAGGSFQKAQTEWNTGTWR 19 1 Q969E2-2;Q969E2 Q969E2-2 SCAMP4 Secretory carrier-associated membrane protein 4 1 40541000.0 3629000.0 11013000.0 25899000.0 True False 5505458.315437583 9047644.105038268 20780051.29806507 1.0 1.6433952609664153 3.774445306360191 22.392431238815217 -6.949206364444192 0.5674887507126032 0.9731455724012205 4.547859384527695 0.9991375286595524 0.03482136125090291 0.08380598461399037 0.03729325517858817 0.03699764947539242 0.17745056845936838 1.1240707204587031e-07 6.949206364444192 3.5747138121264745 GAGGSFQK(ub)AQTEWNTGTWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAGGSFQKAQTEWNTGTWR 19 1 Q969E2-2;Q969E2 Q969E2-2 SCAMP4 Secretory carrier-associated membrane protein 4 1 30315000.0 3629000.0 8305000.0 18381000.0 True False 4697812.038284524 7842819.449318278 15035846.604986796 1.0 1.6694621635356444 3.2006062572221086 22.163557560907666 -6.957339839592141 0.47143865886138947 0.9601184867099193 3.972870776346179 0.9996584317206985 0.017022726019283754 0.08066555195295495 0.024749734475538958 0.021228197780440865 0.1263610451272507 1.1032150057434145e-07 6.957339839592141 3.0127522896362597 GAGHPCYLDKPEEWHTGLLDFLQGLQ ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAGHPCYLDKPEEWHTGLLDFLQGLQ 26 1 Q96IU4;F8W9U3;Q96IU4-2 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 59855400.0 22900100.0 21186300.0 15769000.0 False True 34741125.921563014 17405439.23568257 12652250.23820177 1.0 0.5010038901726963 0.3641865340451966 25.05014117517214 -13.999999999999996 0.18156805698080117 3.60165626557219 0.2572468267782881 0.999496330864838 0.006132361352327966 12.225421697446825 0.1350922496815809 11.22502833732916 0.10080748161264033 1.0000000000000082e-14 13.999999999999996 -3.3444094387939023 GAGHPCYLDKPEEWHTGLLDFLQGLQ ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAGHPCYLDKPEEWHTGLLDFLQGLQ 26 1 Q96IU4;F8W9U3;Q96IU4-2 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 37957300.0 22900100.0 4834500.0 10222700.0 False True 29644630.878456715 4565455.825132951 8362273.493759788 1.0 0.15400616198769235 0.28208391354391266 24.82126749726459 -10.161078040485057 5.369148545371045 1.0000244841546122 0.21804503776557554 0.9802760643566538 0.052287523120078415 1.5325162376491555e-05 2.394531911259056e-06 0.05062875682793774 0.016875725521426486 6.901157824403587e-11 10.161078040485057 -0.7819794463890366 GAGPGCYLAGSLTLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAGPGCYLAGSLTLSK 16 0 A0A494C1B8;A0A494C0U1;Q5VZU9;P29144;A0A494C1L2 A0A494C1B8 TPP2 Tripeptidyl-peptidase 2 0 6798900.0 1412700.0 2970400.0 2415800.0 False True 1852063.3806062613 2527227.8985285102 2165836.1899899216 1.0 1.364547199081944 1.1694179652107526 20.82070204012628 -10.145242644171438 4.229045027141833 0.9999385682555523 1.2669825820715712 0.713966019167003 0.07966117626366909 55699454.48911959 4.490513293859222 35154.36931936056 0.027270139480736942 7.157434063035436e-11 10.145242644171438 0.26704401381601894 GAGPGCYLAGSLTLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAGPGCYLAGSLTLSK 16 0 A0A494C1B8;A0A494C0U1;Q5VZU9;P29144;A0A494C1L2 A0A494C1B8 TPP2 Tripeptidyl-peptidase 2 0 14156500.0 5093600.0 5342500.0 3720400.0 False True 6593765.609866648 5045185.178565061 3043325.3745276597 1.0 0.765144755982173 0.4615458835803549 22.652671173424807 -6.967610778557749 0.30999043124207626 1.0467772099106365 0.17026304932462774 0.9999572922088833 0.0014404551090811302 0.07708583871199291 0.011791169217342187 0.004803750368111579 0.026954035438951883 1.0774303908683927e-07 6.967610778557749 -0.8765141605860087 down GAGSK(ub)TLQQNAESR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAGSKTLQQNAESR 14 1 O95816;O95816-2 O95816 BAG2 BAG family molecular chaperone regulator 2 1 59767350.0 9566650.0 15974900.0 34225800.0 True False 12541970.793570373 13591507.189672502 30684442.533056147 1.0 1.0836819359075667 2.446540742128541 23.58026072931403 -6.919453676811782 0.8287804674827732 0.9693333291295427 2.6635673897372008 0.9940275907472154 0.05124237423099888 0.0984941100668648 0.10729162911419705 0.044023322682890456 0.13118754513825592 1.2037777815927717e-07 6.919453676811782 1.694234060607658 up GAGSK(ub)TLQQNAESR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAGSKTLQQNAESR 14 1 O95816;O95816-2 O95816 BAG2 BAG family molecular chaperone regulator 2 1 167591800.0 18944200.0 24579200.0 124068400.0 True False 18342826.740530822 34393802.738834724 91571164.06778225 1.0 1.875054658987604 4.992205692345338 24.128712648307957 -6.947539553429047 0.5852327141551171 0.9634240710236986 6.0594077422512775 0.9989937835427601 0.05434897154201021 0.08448903910888679 0.04016910074266625 0.05662622099866395 0.26077495381912685 1.128393164286776e-07 6.947539553429047 5.095983671227579 GAGSK(ub)TLQQNAESR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAGSKTLQQNAESR 14 1 O95816;O95816-2 O95816 BAG2 BAG family molecular chaperone regulator 2 1 60880050.0 6261250.0 24148500.0 30470300.0 True False 9498774.008689327 19839011.501908343 24447831.849393107 1.0 2.0885865358792546 2.5737881359245542 23.179309888481146 -9.669406287070379 0.2179405506759402 1.6492165669495997e-21 2.960029754806988 0.9993244809447085 0.01710317243189262 1.1020339604968796 0.09140970266543275 0.9638694834195555 0.2551470573211932 2.1408868417666548e-10 9.669406287070379 2.960029754806988 GAGSK(ub)TLQQNAESR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAGSKTLQQNAESR 14 1 O95816;O95816-2 O95816 BAG2 BAG family molecular chaperone regulator 2 1 62357820.0 9566650.0 12199870.0 40591300.0 True False 13103699.033995342 11660839.403824892 31004470.944064833 1.0 0.8898891353939683 2.3660853979955547 23.643470790836922 -6.888933489858304 1.028699148281051 0.9186420413218768 2.4904173043136093 0.9802058170661021 0.09446591729417692 0.12001160174287566 0.22695034208673134 0.07006753896139568 0.17401759607431241 1.2914170328685045e-07 6.888933489858304 1.5717752629917325 up GAGSK(ub)TLQQNAESR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAGSKTLQQNAESR 14 1 O95816;O95816-2 O95816 BAG2 BAG family molecular chaperone regulator 2 1 85615700.0 18944200.0 28794700.0 37876800.0 True False 15752941.67035763 28639577.235799573 45796663.75746399 1.0 1.8180462947876443 2.9071817007765444 23.909117923742233 -6.967163038933886 0.31875402170925965 0.8486454392337721 3.9116477091719126 0.9999510409471846 0.005466259283364265 0.0772344253501105 0.01231100307416475 0.016593317355152647 0.09590908789206637 1.0785417497619869e-07 6.967163038933886 3.0630022699381403 GAGSK(ub)TLQQNAESR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAGSKTLQQNAESR 14 1 O95816;O95816-2 O95816 BAG2 BAG family molecular chaperone regulator 2 1 32819910.0 6261250.0 17127800.0 9430860.0 True False 8105311.552689164 16174622.873453764 7714540.24879527 1.0 1.995558439463981 0.9517882438751852 22.950436210573596 -6.656918723156217 1.9842307217471378 1.64245809267204 0.9561924556990001 0.22247133934148988 0.42420223446185235 0.49175853809404685 3.7187468735929494 0.1729362940012047 0.46998671850970036 2.203338772379369e-07 6.656918723156217 -0.6862656369730399 GAGTGGLGLAVEGPSEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAGTGGLGLAVEGPSEAK 18 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 6236900.0 1254000.0 3250600.0 1732300.0 False True 1644006.143753273 2765623.150739561 1553058.2133949555 1.0 1.6822462380983756 0.9446790812163981 20.648784259794997 -6.663660513187191 1.9597080893379861 1.437831438229964 0.9477228712336727 0.25125316944742526 0.29023464970346335 0.47589610657699183 3.517079597724339 0.11948897530458585 0.32192328400911835 2.1693992556713126e-07 6.663660513187191 -0.49010856699629124 GAGTGGLGLAVEGPSEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAGTGGLGLAVEGPSEAK 18 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 6103900.0 1254000.0 2410100.0 2439800.0 False True 1717637.6880757797 2303613.812865085 1863569.4892582763 1.0 1.341152344791501 1.0849607587185512 20.71199432131789 -9.95486566200228 5.730337122496544 0.9999997814674346 1.2130565517551806 0.47974764580519624 0.10458977704605363 2.9195556571959386e-07 5.3194542289841804e-08 0.10126872029211076 0.0337562053901631 1.109517963466549e-10 9.95486566200228 0.21305677028774594 GAGTGGLGLTVEGPCEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAGTGGLGLTVEGPCEAK 18 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 4720000.0 1037700.0 1047800.0 2634500.0 False True 1421365.7327880703 1001504.7313887554 2012285.359230645 1.0 0.7046073422807658 1.415740729364187 20.438846392722574 -6.793889283863702 1.4806677503432488 0.8357307323689556 1.424143981573592 0.8136824525955615 0.1259115403644789 0.22961552384986006 0.9943397061405814 0.06691820589903776 0.1562460111254457 1.6073509681123733e-07 6.793889283863702 0.5884132492046363 GAGTNEK(ub)VLTEIIASR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAGTNEKVLTEIIASR 16 1 P08758;D6RBL5;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 1 39462800.0 9472800.0 11442000.0 18548000.0 True False 14370930.154443983 9400085.703245966 14881979.670122795 1.0 0.6541041952207344 1.0355613387711566 23.776650107062782 -6.6679378500741135 1.9445093562246794 0.7788293686476467 1.0340125992072662 0.27003044504970164 0.14699851818501092 0.4658618316603113 3.3939030564450823 0.06090023389431691 0.16315925022520747 2.148137862463105e-07 6.6679378500741135 0.25518323055961945 GAGTNEK(ub)VLTEIIASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAGTNEKVLTEIIASR 16 1 P08758;D6RBL5;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 1 18447700.0 4138300.0 3445400.0 10864000.0 True False 5668341.343352472 3293170.8355858107 8298146.951103321 1.0 0.5809760979634484 1.4639462319669483 22.434495208231823 -6.777647096591873 1.5449141843637608 0.7620129448441901 1.4704462578372484 0.7590123411740137 0.17703334051226707 0.2542505523728476 1.1984264335227506 0.09026730849923599 0.21342666912274086 1.6686025517680047e-07 6.777647096591873 0.7084333129930582 GAGWLFGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAGWLFGAK 9 0 O00743-2;O00743;O00743-3 O00743-2 PPP6C Serine/threonine-protein phosphatase 6 catalytic subunit;Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed 0 8917300.0 2034400.0 1798100.0 5084800.0 False True 2667118.101157624 1529830.488938903 4558673.672845739 1.0 0.5735893315991153 1.7092132781323455 21.346850278795703 -6.804995840576388 1.435405489514019 0.766195494736628 1.7268954005333348 0.846361760365606 0.1835910971699885 0.21371163390480885 0.8687174110581529 0.10059555264153318 0.23327588538981608 1.566766075623701e-07 6.804995840576388 0.9606999057967068 GAGWLFGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAGWLFGAK 9 0 O00743-2;O00743;O00743-3 O00743-2 PPP6C Serine/threonine-protein phosphatase 6 catalytic subunit;Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed 0 6720300.0 2034400.0 2614600.0 2071300.0 False True 2786572.6575927977 2499078.3266740204 1582101.5997625466 1.0 0.8968286973837132 0.5677589620538577 21.410060340318594 -6.950065643417945 0.5581216019666736 1.004346845761645 0.444564643769996 0.9992064302035256 0.005192349042104354 0.08345937795476185 0.03585323099090039 0.0055786140311309676 0.02734358823448217 1.1218488745274821e-07 6.950065643417945 -0.559782201991649 GAGYTFGQDISETFNHANGLTLVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAGYTFGQDISETFNHANGLTLVSR 25 0 P67775;H0YC23;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0 12803000.0 4974400.0 2518500.0 5310100.0 False True 4816490.394848901 3524150.1838040003 3919225.5104146614 1.0 0.7316842544880767 0.8137098154718966 22.199550858057695 -10.266571060312204 7.756984163841201 1.0000004649523322 0.7726970349799867 0.9110227991940127 0.0334867950459838 2.692325962018558e-07 2.5474842687280966e-08 0.03242351607174191 0.010807816627579691 5.412886736762062e-11 10.266571060312204 -0.22730342997234554 GAGYTFGQDISETFNHANGLTLVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAGYTFGQDISETFNHANGLTLVSR 25 0 P67775;H0YC23;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0 8072300.0 4974400.0 1332000.0 1765900.0 False True 4136434.0032847524 1324824.2516187017 2135141.52540092 1.0 0.320281733146632 0.5161792799559715 21.97995613349197 -10.309488997243195 5.247128584216703 1.0001385322614629 0.4182305065513521 0.9216259870708685 0.07997483859115836 0.00012963723968336484 1.7060147520252916e-05 0.07745352304430814 0.0258117681649058 4.903554456837316e-11 10.309488997243195 -0.5819080257101108 GAHNGQGLGNAFLSHISACDGIFHLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAHNGQGLGNAFLSHISACDGIFHLTR 27 0 J3KQ32;Q9NTK5;Q9NTK5-3 J3KQ32 OLA1 Obg-like ATPase 1 0 13083300.0 3550100.0 6827400.0 2705800.0 False True 4654215.479217303 5808778.532996756 2425829.7718663462 1.0 1.2480682424213017 0.5212113153545476 22.15010657499692 -6.814574574671452 1.3950135111115773 1.1344831549724843 0.507093397729659 0.871497048134717 0.10814416299645925 0.20061758123714182 0.7685230587283177 0.060938255407533067 0.14070738337654248 1.5325880161408184e-07 6.814574574671452 -0.6273897572428253 GAHNGQGLGNAFLSHISACDGIFHLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAHNGQGLGNAFLSHISACDGIFHLTR 27 0 J3KQ32;Q9NTK5;Q9NTK5-3 J3KQ32 OLA1 Obg-like ATPase 1 0 58984000.0 18346000.0 18691000.0 21947000.0 False True 17763616.27209267 26154413.77227736 16198422.304113032 1.0 1.4723586330429215 0.911887650351994 24.08242197600815 -6.683263897041478 1.8902177834938625 1.2979905973713968 0.9139622455469937 0.3390944634750054 0.2000563513516302 0.4313499119895818 2.982438956431175 0.08483688818763235 0.222826335725101 2.0736530887991282e-07 6.683263897041478 -0.3840283518244031 GAHNGQGLGNAFLSHISACDGIFHLTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAHNGQGLGNAFLSHISACDGIFHLTR 27 0 J3KQ32;Q9NTK5;Q9NTK5-3 J3KQ32 OLA1 Obg-like ATPase 1 0 47765000.0 9226000.0 18571000.0 19968000.0 False True 13996516.510947136 15256859.954114748 16021316.047714677 1.0 1.0900469371919688 1.1446645338633994 23.73856447440154 GAHNGQGLGNAFLSHISACDGIFHLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAHNGQGLGNAFLSHISACDGIFHLTR 27 0 J3KQ32;Q9NTK5;Q9NTK5-3 J3KQ32 OLA1 Obg-like ATPase 1 0 35937100.0 3550100.0 10984000.0 21403000.0 False True 4862667.907845159 10498690.560769316 16348052.208621547 1.0 2.1590391858410296 3.36195120013162 22.21331663651981 -6.97065858862965 0.24194479940314864 0.5783526360636203 4.977513963214729 0.9999870720844029 0.0034672401214137978 0.07608960488249629 0.008262018803434688 0.028362604803968766 0.11686949632474652 1.069895624402915e-07 6.97065858862965 4.399161327151109 GAHNGQGLGNAFLSHISACDGIFHLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAHNGQGLGNAFLSHISACDGIFHLTR 27 0 J3KQ32;Q9NTK5;Q9NTK5-3 J3KQ32 OLA1 Obg-like ATPase 1 0 43774500.0 18346000.0 7307500.0 18121000.0 False True 15255511.865604281 7268133.0470748255 21910017.31796256 1.0 0.47642669161838247 1.436203354628946 23.862827251442425 -6.758581955987103 1.6178255774489863 0.6953388258126958 1.4394622279700033 0.6851198516738728 0.22017407920076584 0.28531961626911234 1.471515193435505 0.10739502025183924 0.2584480346927905 1.7434843123893788e-07 6.758581955987103 0.7441234021573075 GAHNGQGLGNAFLSHISACDGIFHLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAHNGQGLGNAFLSHISACDGIFHLTR 27 0 J3KQ32;Q9NTK5;Q9NTK5-3 J3KQ32 OLA1 Obg-like ATPase 1 0 55168000.0 9226000.0 28220000.0 17722000.0 False True 11943238.871648673 26649532.19262631 14496777.843075791 1.0 2.2313488392070937 1.213806237894882 23.509690796493988 -6.59905768878717 2.1936717955765697 1.828577176162108 1.2170231513546523 0.018019684532746494 0.5323452327213406 0.6433597114861843 5.849345344998441 0.2015142336176243 0.5924601465988336 2.517342518530891e-07 6.59905768878717 -0.6115540248074556 GAHSVGLMWWMLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAHSVGLMWWMLAR 14 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 25553500.0 9963400.0 7735300.0 7854800.0 False True 9647117.320689432 10824045.629056612 5797392.2410510285 1.0 1.1219979263487458 0.6009455517471324 23.2016664807786 -6.845013155794222 1.2588732824600273 1.0649239970408253 0.5820319335483658 0.9327307190052248 0.05771267313100777 0.16303322835757636 0.4996987362836236 0.03591422923557713 0.08288710010360188 1.4288506746312752e-07 6.845013155794222 -0.4828920634924595 GAHSVGLMWWMLAR ddPTM_RPMI8226_Bortezomib_8h_R1 3 GAHSVGLMWWMLAR 14 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 402195100.0 66347700.0 109204100.0 226643300.0 False True 100654311.56659086 89715775.13947225 181847152.4137126 1.0 0.8913257042160395 1.8066504015916516 26.58483373108506 -6.877275961860266 1.0949408464129844 0.9347998095773198 1.8682078342742663 0.9714181240279699 0.06902640092636503 0.1300674435614142 0.2871351398267334 0.048677155756939004 0.11693524407628379 1.3265512651442878e-07 6.877275961860266 0.9334080246969465 GAHSVGLMWWMLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAHSVGLMWWMLAR 14 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 14173300.0 1062600.0 4883700.0 8227000.0 False True 1455471.9356852677 4667921.985763756 6283952.040383564 1.0 3.2071535502098136 4.317466992192428 20.47305559110156 -8.876404663284928 0.2770082928582225 3.6375302976214025e-14 4.948389275688132 0.9989070611712199 0.04558275096781966 0.38036880346231444 0.09055107507946585 0.795087072476842 0.4086304020580774 1.329215315642912e-09 8.876404663284928 4.948389275688095 GAHSVGLMWWMLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAHSVGLMWWMLAR 14 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 27924800.0 9963400.0 8685800.0 9275600.0 False True 8285008.553459167 8639007.871403696 11215085.074471254 1.0 1.0427276949275721 1.3536600477966578 22.982071756212875 -6.931901572520029 0.7310068946099043 0.9955895445287289 1.4206998402911724 0.9968991310907775 0.008776812969727762 0.09166207121474455 0.07292848549589014 0.008088576960228426 0.027845579019084597 1.1697644736490503e-07 6.931901572520029 0.4251102957624434 GAHSVGLMWWMLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 4 GAHSVGLMWWMLAR 14 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 402524100.0 85612900.0 159392500.0 157518700.0 False True 110827586.73255707 150522167.2577316 128851912.87834892 1.0 1.3581651617206396 1.1626339314712963 26.723741794714467 -10.176846079033465 4.307560715288843 0.9999291224550222 1.2603995465574769 0.7028019081078402 0.0798252905479894 5.682598359446896e-05 1.0859041692753458e-05 0.07731245711326261 0.025763501732054474 6.655089815222056e-11 10.176846079033465 0.2604704241024547 GAHVTINAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAHVTINAR 9 0 Q9UJU6;H0Y5J4;Q9UJU6-5;Q9UJU6-2;Q9UJU6-3 Q9UJU6;Q9UJU6-2 DBNL Drebrin-like protein 0 32674200.0 11220000.0 8029200.0 13425000.0 False True 14709528.654634576 6831274.657576462 12035909.7816933 1.0 0.4644115265667681 0.8182389840140193 23.810247682489116 -10.14893316174893 7.484550459789673 1.0000001530551856 0.641325255290401 0.5780796835516862 0.14444945462201556 3.689171585742139e-07 4.190760142489507e-08 0.13986264242625918 0.04662086100998418 7.096869809253147e-11 10.14893316174893 -0.3586748977647847 GAHVTINAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAHVTINAR 9 0 Q9UJU6;H0Y5J4;Q9UJU6-5;Q9UJU6-2;Q9UJU6-3 Q9UJU6;Q9UJU6-2 DBNL Drebrin-like protein 0 2585100.0 0.0 2585100.0 0.0 False True 0.0 3617343.9111184096 0.0 0.0 GAHVTINAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAHVTINAR 9 0 Q9UJU6;H0Y5J4;Q9UJU6-5;Q9UJU6-2;Q9UJU6-3 Q9UJU6;Q9UJU6-2 DBNL Drebrin-like protein 0 13893400.0 4200700.0 5974600.0 3718100.0 False True 6372769.012306057 4908385.950237131 2983215.9052988794 1.0 0.7702124368165318 0.46811925860456843 22.603488939027645 -6.967356068029302 0.31500474679724955 1.0438732170175409 0.18478569164331715 0.9999538004302443 0.0014804299713561484 0.0771702880091559 0.012086575029228922 0.004675528988606043 0.026693243732274854 1.0780624812306418e-07 6.967356068029302 -0.8590875253742237 down GAHVTINAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAHVTINAR 9 0 Q9UJU6;H0Y5J4;Q9UJU6-5;Q9UJU6-2;Q9UJU6-3 Q9UJU6;Q9UJU6-2 DBNL Drebrin-like protein 0 23345100.0 11220000.0 6073800.0 6051300.0 False True 15368337.209099112 5805439.432629332 4622107.570435524 1.0 0.3777532568189689 0.3007552155804415 23.873457744012008 -13.999999999999998 0.294696225722733 6.506370037321332 0.2807484127815531 0.9996379756506512 0.005956583427747036 16.251083083179346 0.1722610964915272 54.39799204508638 0.02847692035166161 1.0000000000000041e-14 13.999999999999998 -6.225621624539779 GAHVTINAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAHVTINAR 9 0 Q9UJU6;H0Y5J4;Q9UJU6-5;Q9UJU6-2;Q9UJU6-3 Q9UJU6;Q9UJU6-2 DBNL Drebrin-like protein 0 8122000.0 0.0 5097400.0 3024600.0 False True 0.0 5069939.294445316 3657029.8758296757 0.0 GAIEVLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAIEVLIR 8 0 P49756;P49756-2;P49756-3;E9PQU5 P49756 RBM25 RNA-binding protein 25 0 5634800.0 1803800.0 1923700.0 1907300.0 False True 2364799.2680240455 1636691.458523869 1709950.8921134924 1.0 0.6921058715869101 0.7230850056640433 21.17328629736377 -10.014346818535975 6.003087878889267 1.0000003540147886 0.7075954388763901 0.9916518385870297 0.012647178527136956 5.992053362449341e-08 9.83331697621753e-09 0.012245592824275103 0.004081859317661993 9.675049183813509e-11 10.014346818535975 -0.2924049151383985 GAIEVLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAIEVLIR 8 0 P49756;P49756-2;P49756-3;E9PQU5 P49756 RBM25 RNA-binding protein 25 0 8402300.0 3063600.0 1929000.0 3409700.0 False True 2966347.6949298577 2699259.7596021113 2516597.2811926054 1.0 0.9099606779797734 0.8483824352398153 21.500256279844905 -6.975160660882996 0.053070357509457995 1.3827843708060152 0.37403011234303046 0.9999999726987386 8.51439887141329e-06 0.07466220081053956 0.0015212377861858351 0.012163942178120118 0.01669919632534117 1.0588619422469094e-07 6.975160660882996 -1.0087542584629847 GAIEVLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAIEVLIR 8 0 P49756;P49756-2;P49756-3;E9PQU5 P49756 RBM25 RNA-binding protein 25 0 20260000.0 5297600.0 8617200.0 6345200.0 False True 8036846.506437638 7079393.333509099 5091068.438800044 1.0 0.88086705747564 0.6334659290459287 22.93819809784552 -6.959302252366716 0.44515781440717417 1.00838505918635 0.4962190309371581 0.999743439310276 0.002445235429810762 0.07995130079841313 0.022059362953114822 0.0032839245269491893 0.02047984198475742 1.0982412394540264e-07 6.959302252366716 -0.5121660282491918 GAIEVLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAIEVLIR 8 0 P49756;P49756-2;P49756-3;E9PQU5 P49756 RBM25 RNA-binding protein 25 0 9744900.0 1803800.0 2768600.0 5172500.0 False True 2470713.6058621136 2646274.0974641186 3950862.030981404 1.0 1.071056593198606 1.5990772955665242 21.23649635888666 -6.93149522869046 0.7344105292819549 0.9923995581736036 1.7117253581211702 0.996824161129753 0.015060121717360543 0.0918685509304295 0.0739295789408272 0.01384467755363811 0.04738991690769282 1.1708594657170459e-07 6.93149522869046 0.7193257999475666 GAIEVLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAIEVLIR 8 0 P49756;P49756-2;P49756-3;E9PQU5 P49756 RBM25 RNA-binding protein 25 0 5471200.0 3063600.0 1119100.0 1288500.0 False True 2547519.1404919513 1113071.1861760418 1557919.392649123 1.0 0.4369235812536807 0.6115437438276806 21.28066155527918 -10.399874625625657 5.1453238515543696 1.0003886460945244 0.5242336625406575 0.9082381114200345 0.07128838285144451 0.0003180773297197245 3.7098927586958425e-05 0.06907958236956632 0.02300822663012937 3.9822211477842596e-11 10.399874625625657 -0.4761549835538669 GAIEVLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAIEVLIR 8 0 P49756;P49756-2;P49756-3;E9PQU5 P49756 RBM25 RNA-binding protein 25 0 20798200.0 5297600.0 8010700.0 7489900.0 False True 6857847.631307837 7564897.503028765 6126815.052863857 1.0 1.1031008429661027 0.8934020384024532 22.70932441993797 -6.7730205265982955 1.5628394559460552 1.0589090267181362 0.8920847034105004 0.7419580510552901 0.04348962003038922 0.2615949971770253 1.2613519755362361 0.02192839582453167 0.05205652190997928 1.6864733136268225e-07 6.7730205265982955 -0.16682432330763586 GAIQFVTHYQHSSTQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAIQFVTHYQHSSTQR 16 0 A0A2R8YFH5;Q15437 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 0 30863000.0 11974900.0 11490800.0 7397300.0 False True 15699209.86509656 9776417.430787584 6631898.355912087 1.0 0.6227330875118188 0.4224351679415744 23.90418861489581 -11.057763288464775 0.11299990810089515 2.0146264973074275 3.306084843671534e-11 0.9998413061354643 0.003016447661326405 3.4015159968039335 0.06837986448394638 1.171065223198086 0.27939072065124326 8.754608137727043e-12 11.057763288464775 -2.014626497274367 GAIQFVTHYQHSSTQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAIQFVTHYQHSSTQR 16 0 A0A2R8YFH5;Q15437 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 0 18626100.0 3094300.0 1066400.0 14465400.0 False True 2996073.1402341896 1492219.0812025326 10676477.78730198 1.0 0.49805829542795893 3.563490371422457 21.514641412668627 -6.864891899035461 1.1608696755796095 0.7232734750711475 3.726347843986355 0.9593085314214194 0.2708070071034662 0.14184149271826527 0.36049728117595975 0.18155959716202696 0.4264020426257461 1.3649228395318637e-07 6.864891899035461 3.0030743689152075 up GAIQFVTHYQHSSTQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAIQFVTHYQHSSTQR 16 0 A0A2R8YFH5;Q15437 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 0 25164100.0 11974900.0 6967400.0 6221800.0 False True 16402344.139504524 6659557.229889299 4752338.9819932515 1.0 0.4060125292609833 0.2897353537746714 23.9673986764187 -13.999999999999998 0.22929445177408048 4.737465340475663 0.23281953124671817 0.9995088384487735 0.006893730708928009 13.269384632841705 0.151622680808113 22.569766489504303 0.060624225302884804 1.0000000000000041e-14 13.999999999999998 -4.504645809228945 GAIQFVTHYQHSSTQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAIQFVTHYQHSSTQR 16 0 A0A2R8YFH5;Q15437 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 0 8846800.0 3094300.0 3910400.0 1842100.0 False True 2573047.550732552 3889333.8990463708 2227274.593091927 1.0 1.511567051273137 0.8656173464255712 21.295046688102904 -6.695643837728096 1.8462368781963057 1.3190156038206216 0.8676812682733476 0.39691093247460774 0.2161171114159681 0.4047083020024778 2.6787107515531576 0.09349278798870692 0.24175513427413886 2.0153763702668177e-07 6.695643837728096 -0.451334335547274 GAIQLGIGYTVGHLSSK(ub)PER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAIQLGIGYTVGHLSSKPER 20 1 O60331-4;O60331;O60331-2;O60331-3 O60331-4 PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1 46028500.0 13789500.0 25687000.0 6552000.0 True False 18078168.037707966 21854599.727141783 5874061.891221941 1.0 1.2088946004681904 0.32492572693038657 24.107745152981096 -6.84440346253749 1.2618712785376334 1.1111437979283525 0.29323898315044195 0.93174722761793 0.09855378606230993 0.16372196955267643 0.504507041050295 0.06119393031633724 0.14118395652780494 1.4308580047774657e-07 6.84440346253749 -0.8179048147779105 down GAIQLGIGYTVGHLSSK(ub)PER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAIQLGIGYTVGHLSSKPER 20 1 O60331-4;O60331;O60331-2;O60331-3 O60331-4 PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1 129433000.0 36838000.0 51347000.0 41248000.0 True False 35668597.85410172 71850124.87106766 30443911.386524532 1.0 2.014380412848363 0.8535213946747174 25.088151168250256 -6.67575502330615 1.9165915580370505 1.6442134828989576 0.8580264384761627 0.30502427917059527 0.4303181996336368 0.44798838389885887 3.177692944927446 0.1803907930705742 0.47843786271682837 2.1098179197634403e-07 6.67575502330615 -0.786187044422795 GAIQLGIGYTVGHLSSK(ub)PER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAIQLGIGYTVGHLSSKPER 20 1 O60331-4;O60331;O60331-2;O60331-3 O60331-4 PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1 373321000.0 82498000.0 198286000.0 92537000.0 True False 125155497.41167557 162900314.08441076 74247021.38959216 1.0 1.3015833699144728 0.5932381950859935 26.899146421394615 -6.791008265706235 1.4921886711183825 1.1683326939256462 0.5854813339590964 0.8046173669379395 0.12829281199445147 0.23384620113712512 1.0285951379426979 0.06766799374070133 0.15831952905723565 1.618049241840819e-07 6.791008265706235 -0.5828513599665498 GAIQLGIGYTVGHLSSK(ub)PER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAIQLGIGYTVGHLSSKPER 20 1 O60331-4;O60331;O60331-2;O60331-3 O60331-4 PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1 82491500.0 13789500.0 34622000.0 34080000.0 True False 18887850.797225676 33092285.560356442 26031005.899631917 1.0 1.7520408179641682 1.3781878192015078 24.170955214503987 -10.223866036925195 4.666897860418537 0.9998651042150206 1.5651143185856569 0.7528764684232995 0.15262484763929662 0.00021426748213437103 3.563395193916279e-05 0.14781333131802776 0.04925945775900515 5.972194773180867e-11 10.223866036925195 0.5652492143706362 GAIQLGIGYTVGHLSSK(ub)PER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAIQLGIGYTVGHLSSKPER 20 1 O60331-4;O60331;O60331-2;O60331-3 O60331-4 PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1 111425800.0 36838000.0 60212000.0 14375800.0 True False 30632429.200105242 59887626.004853725 17381713.313810844 1.0 1.955040052933444 0.5674284987411683 24.868556443684533 -6.721488214006075 1.75381648224217 1.5801042689015012 0.5693865627012897 0.5195928160553709 0.4018126443482115 0.35243544312470765 2.119340847949034 0.1818527890867406 0.45574617133553347 1.898942375382457e-07 6.721488214006075 -1.0107177062002115 GAIQLGIGYTVGHLSSK(ub)PER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAIQLGIGYTVGHLSSKPER 20 1 O60331-4;O60331;O60331-2;O60331-3 O60331-4 PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1 357377000.0 82498000.0 235547000.0 39332000.0 True False 106795287.27869867 222438602.387546 32173979.580400456 1.0 2.082850358434435 0.30126778437739044 26.670272743487065 -6.742206289667348 1.6787976451053699 1.6426539462064207 0.29975272589265795 0.6147068503841787 0.45495129618514846 0.3138509372019554 1.737663825286154 0.21432192763604935 0.524622044805576 1.8104799112669926e-07 6.742206289667348 -1.3429012203137627 GAIQLGITHTVGSLSTK(ub)PER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAIQLGITHTVGSLSTKPER 20 1 A6PW58;A2A5X0;A6PW57;Q99755-2;Q99755-4;Q99755-3;Q99755 A6PW58 PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 1 1585425100.0 571486600.0 801877500.0 212061000.0 True False 749224466.8841069 682240502.6940141 190118961.9527494 1.0 0.9105955996489712 0.2537543424648434 29.48082277250261 -6.931716504844669 0.7325650699836171 1.0093797588617925 0.11281804023475843 0.9968649793397675 0.018629342039369043 0.09175631361304848 0.07338523319635376 0.017148908829075864 0.05888186663178615 1.1702630563697044e-07 6.931716504844669 -0.8965617186270342 down GAIQLGITHTVGSLSTK(ub)PER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAIQLGITHTVGSLSTKPER 20 1 A6PW58;A2A5X0;A6PW57;Q99755-2;Q99755-4;Q99755-3;Q99755 A6PW58 PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 1 1745260000.0 517610000.0 572710000.0 654940000.0 True False 501178753.87538916 801396089.6431953 483391566.2211592 1.0 1.5990224714163577 0.964509294305296 28.900750015880973 -5.529858229522813 18.620695996657382 1.2535892945876081 1.2071706346603186 0.0 0.29843975187599564 106996675.18183963 0.0 0.09117513139707187 0.0 2.9521727724981657e-06 5.529858229522813 -0.04641865992728955 GAIQLGITHTVGSLSTK(ub)PER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAIQLGITHTVGSLSTKPER 20 1 A6PW58;A2A5X0;A6PW57;Q99755-2;Q99755-4;Q99755-3;Q99755 A6PW58 PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 1 5274266000.0 1623430300.0 2442694700.0 1208141000.0 True False 2462862453.752645 2006776745.9241996 969351401.802988 1.0 0.8148147871053412 0.3935873074543788 31.197688912261615 -6.957452793108663 0.46995825719927187 1.0111302911744913 0.18000474153100984 0.9996637501138197 0.004652883238893531 0.08062389410190055 0.024590799102442752 0.0058236996586413115 0.0347663223452889 1.1029281132865392e-07 6.957452793108663 -0.8311255496434814 down GAIQLGITHTVGSLSTK(ub)PER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAIQLGITHTVGSLSTKPER 20 1 A6PW58;A2A5X0;A6PW57;Q99755-2;Q99755-4;Q99755-3;Q99755 A6PW58 PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 1 1448746600.0 571486600.0 468760000.0 408500000.0 True False 782780639.8646641 448048633.2179735 312020713.32158625 1.0 0.5723808311041484 0.3986055574592799 29.5440328340255 -13.999999999992857 0.12393420705777389 3.0336346256041637 0.1354015184332142 0.9996738765026498 0.004563539969640383 11.9503760648431 0.10883174001590196 5.956762008799057 0.2336792580289671 1.0000000000164468e-14 13.999999999992857 -2.8982331071709497 GAIQLGITHTVGSLSTK(ub)PER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAIQLGITHTVGSLSTKPER 20 1 A6PW58;A2A5X0;A6PW57;Q99755-2;Q99755-4;Q99755-3;Q99755 A6PW58 PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 1 1641580000.0 517610000.0 831800000.0 292170000.0 True False 430415649.0109797 827318928.300627 353261396.1585526 1.0 1.9221395183973027 0.8207447776824236 28.68115529131525 -6.684616336939542 1.8857542554842248 1.581016980263445 0.824798852231243 0.34529340628452043 0.3904365847267499 0.4283259969363431 2.948769221863145 0.16590745287359987 0.4349560814634598 2.0672055536037672e-07 6.684616336939542 -0.756218128032202 GAIQLGITHTVGSLSTK(ub)PER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAIQLGITHTVGSLSTKPER 20 1 A6PW58;A2A5X0;A6PW57;Q99755-2;Q99755-4;Q99755-3;Q99755 A6PW58 PIP5K1A Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 1 3764693600.0 1623430300.0 1563003300.0 578260000.0 True False 2101562525.9454043 1476020792.3646777 473022613.4486514 1.0 0.7023444575843292 0.22508138949416148 30.968815234354064 -7.202923100245068 0.43256555610795877 1.0216036755272244 1.5212918105912085e-12 0.9995404659513846 0.006842158746086386 0.08858699221456359 0.029171712827142017 0.00947301523211582 0.045654498965048244 6.267248279035871e-08 7.202923100245068 -1.0216036755257032 down GAK(ub)AEEILEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAKAEEILEK 10 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 6114500.0 1936300.0 2411600.0 1766600.0 True False 2538508.0511558726 2051798.680343171 1583809.1784237889 1.0 0.8082695185500454 0.623913395784829 21.275549405064048 -6.971603334811942 0.2164941661082873 1.0888718482051123 0.3381264245747942 0.9999923317122211 0.00042515689717438453 0.07578579361094606 0.007138559829017943 0.005246335439568466 0.018826870832802656 1.0675707475250498e-07 6.971603334811942 -0.7507454236303182 GAK(ub)AEEILEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAKAEEILEK 10 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 11393800.0 3425000.0 3857300.0 4111500.0 True False 3316275.2497502128 5397540.005553763 3034574.8076439016 1.0 1.6275910770555957 0.9150551685576975 21.661132324339242 -6.67411031657255 1.9225523338796138 1.3991543455696533 0.9178599014078134 0.29751885746680584 0.26633528786933214 0.451729539163733 3.2227188167853993 0.1113658336653639 0.29598305021746907 2.1178231116910155e-07 6.67411031657255 -0.48129444416184 GAK(ub)AEEILEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAKAEEILEK 10 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 42870700.0 3802100.0 4535600.0 34533000.0 True False 5768063.670742695 3726186.7431954495 27707537.413648445 1.0 0.6460030533462655 4.803611574918837 22.459655659172977 -6.886201125597401 1.0446188707421094 0.7558405668257223 5.13565067773157 0.9783523325484297 0.2769064841582636 0.1222784736336517 0.2402992340754653 0.2029197631151144 0.49942449163116914 1.299567597459108e-07 6.886201125597401 4.379810110905847 up GAK(ub)AEEILEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAKAEEILEK 10 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 6607700.0 1936300.0 2789200.0 1882200.0 True False 2652202.4365399797 2665963.9213490286 1437663.125125801 1.0 1.0051887007641098 0.5420638731488961 21.33875946658694 -6.904366235038417 0.9332430620597346 1.0170169660685557 0.48889855367503204 0.988616388698852 0.023163960085480922 0.10826263317578629 0.1598450354290137 0.018451499092134227 0.04915016640940454 1.2463320549207472e-07 6.904366235038417 -0.5281184123935236 GAK(ub)AEEILEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAKAEEILEK 10 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 12068200.0 3425000.0 5696800.0 2946400.0 True False 2848039.253226571 5666110.207673736 3562478.6173856277 1.0 1.9894775682092674 1.2508530608732522 21.44153759977352 -10.15696820557349 4.567728932567942 0.999931872683026 1.6201653143691443 0.48452366059542784 0.30154219265654353 211083345.7424211 33.54536991016356 194143.59382024498 0.10322591306019764 6.96677515567619e-11 10.15696820557349 0.6202334416861184 GAK(ub)AEEILEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAKAEEILEK 10 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 71547500.0 3802100.0 5553400.0 62192000.0 True False 4921893.400595645 5244348.408169064 50873694.14380814 1.0 1.0655144232775124 10.336203977447262 22.230781981265427 -6.908447550206563 0.9062188848653355 0.6986764064343531 11.495427344052413 0.990322944932584 0.4314369153171105 0.1054542686705301 0.14439337060714233 0.35053381495384933 0.9575611998492386 1.2346744179352838e-07 6.908447550206563 10.796750937618059 up GAK(ub)EHGAVAVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAKEHGAVAVER 12 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 GAK(ub)EHGAVAVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAKEHGAVAVER 12 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 83093000.0 30003000.0 32354000.0 20736000.0 True False 29050571.187811892 45273120.9238811 15304619.533334296 1.0 1.5584244671538625 0.5268268026260123 24.792063194165692 -6.759735986560965 1.6139296367312956 1.3244789128603724 0.5231671641030385 0.689708734200611 0.23486227609801755 0.2833613846394817 1.4547255472869316 0.11483226818360483 0.2759807438418975 1.738857582350265e-07 6.759735986560965 -0.8013117487573339 GAK(ub)EHGAVAVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAKEHGAVAVER 12 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 33430000.0 19306000.0 0.0 14124000.0 True False 29288613.457657196 0.0 11332385.209230874 1.0 0.0 0.38692119125455365 24.803836560907467 -10.670927635611346 6.622733276592271 1.0053366299859434 0.19346059562728618 0.8528015904197602 0.15795991487391292 0.012446420120099144 0.0006184407990154344 0.1529409881148131 0.0509813433062505 2.1334003617145334e-11 10.670927635611346 -0.8118760343586573 GAK(ub)EHGAVAVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAKEHGAVAVER 12 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 GAK(ub)EHGAVAVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAKEHGAVAVER 12 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 69737000.0 30003000.0 33553000.0 6181000.0 True False 24948823.858264785 33372243.329250954 7473418.522285005 1.0 1.3376279186081048 0.2995499332851031 24.57246846959997 -6.819112069514379 1.3756281184184804 1.1821430136820918 0.27729962305287975 0.8823561905085402 0.14828793518663702 0.19463079106227316 0.7239358717070621 0.08471329645983373 0.19530623643291609 1.516658943734707e-07 6.819112069514379 -0.9048433906292122 down GAK(ub)EHGAVAVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAKEHGAVAVER 12 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 62921000.0 19306000.0 32855000.0 10760000.0 True False 24991997.578154042 31026590.36813386 8801790.406923339 1.0 1.2414610025112505 0.35218434938618687 24.574962882999916 -6.834367168194409 1.3081850793108003 1.128685560612428 0.3260302792884495 0.9143487037713469 0.10988518236014688 0.1754809157509126 0.5857474597952375 0.0659183466615691 0.15171869254558398 1.4643093376466436e-07 6.834367168194409 -0.8026552813239785 down GAK(ub)LTPEEEEILNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAKLTPEEEEILNK 14 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 70923100.0 25239000.0 21611300.0 24072800.0 True False 33088573.414823677 18386978.280187596 21581977.578603078 1.0 0.555689665120172 0.6522486572036482 24.97982975665601 -10.569438937891151 5.577978559268136 1.0015706109927023 0.6039691611619248 0.9573179837865702 0.039420043446993604 0.0007726911354934138 5.9643536390240585e-05 0.038304017136849534 0.012722764314748145 2.695014226604484e-11 10.569438937891151 -0.3976014498307775 GAK(ub)LTPEEEEILNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAKLTPEEEEILNK 14 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 94002700.0 26663500.0 27883900.0 39455300.0 True False 25817081.78736201 39018086.68261755 29120773.296371713 1.0 1.5113283137104097 1.1279653345881613 24.621822600223247 -10.394300059129755 5.48206799951712 0.9998471793289075 1.319646824149288 0.4810468261017963 0.15650728085380128 0.00029246143729673007 3.231372188718391e-05 0.15160940535228085 0.050512507692246855 4.033666059710385e-11 10.394300059129755 0.3197996448203805 GAK(ub)LTPEEEEILNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAKLTPEEEEILNK 14 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 52501700.0 32259800.0 7331900.0 12910000.0 True False 48940475.10728953 6023465.16060383 10358332.841345998 1.0 0.12307737404262864 0.21165166089291104 25.544524771178562 -10.224511429433733 5.5379067124195815 1.0000422543610858 0.16736451746772357 0.9915841814265366 0.03616030118584665 1.886571896824837e-05 2.641792057131725e-06 0.03501382770693558 0.011670687023862031 5.963326257965554e-11 10.224511429433733 -0.8326777368933622 GAK(ub)LTPEEEEILNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAKLTPEEEEILNK 14 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 57719600.0 25239000.0 27860600.0 4620000.0 True False 34570540.358329065 26629626.569316234 3528851.1518867244 1.0 0.7702982450750259 0.10207682944234106 25.0430398181789 -7.198564887044049 0.6614394222419846 0.9985062422115552 1.1168613437291785e-21 0.9968903908456062 0.021238712371052248 0.0876636748990185 0.0675766061123099 0.019813271108433946 0.055737862247988317 6.330457725797762e-08 7.198564887044049 -0.9985062422115552 down GAK(ub)LTPEEEEILNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAKLTPEEEEILNK 14 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 80871600.0 26663500.0 32783700.0 21424400.0 True False 22171881.643330436 32607087.701045025 25904142.984766692 1.0 1.4706504493205077 1.168333089697823 24.402227875657523 -10.1674811362909 4.815588035971408 0.9999687169215146 1.3194917695086632 0.5982528176544679 0.12342054524827133 4.14641033097503e-05 7.168486703416154e-06 0.11951311830030285 0.0398338096931891 6.800155810394834e-11 10.1674811362909 0.31952305258714864 GAK(ub)LTPEEEEILNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAKLTPEEEEILNK 14 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 107740400.0 32259800.0 28781600.0 46699000.0 True False 41760947.03572649 27179878.658940226 38200261.17220383 1.0 0.6508444034012888 0.9147364675308611 25.31565109327101 -10.33054590256106 5.642444568521003 1.000036267808085 0.7827904354660732 0.47460361692379105 0.10773348404788433 4.9160267020304295e-05 5.832467825556564e-06 0.10432989157759975 0.03477083246219559 4.671475736085601e-11 10.33054590256106 -0.21724583234201178 GAKPQGHIGVDASAPQIGGSITGPSVEVQAPDIDVQGPGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAKPQGHIGVDASAPQIGGSITGPSVEVQAPDIDVQGPGSK 41 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 182043000.0 42739000.0 82424000.0 56880000.0 False True 64838187.63942886 67714793.21834864 45637643.06861031 1.0 1.044365915884584 0.7038698139190048 25.950340429339803 -6.874129410499217 1.1120663113571858 1.0258397176662097 0.6823032426537129 0.9686312995599169 0.026769330888922395 0.1329548415787263 0.3048217041561121 0.018631251927091624 0.04445352865670045 1.3361972989033406e-07 6.874129410499217 -0.34353647501249684 GAKPQGHIGVDASAPQIGGSITGPSVEVQAPDIDVQGPGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAKPQGHIGVDASAPQIGGSITGPSVEVQAPDIDVQGPGSK 41 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 118487000.0 42739000.0 53033000.0 22715000.0 False True 55326478.01164031 50081666.93024635 18581103.07558211 1.0 0.9052025129759663 0.3358446758832683 25.721466751432253 -6.93581430443428 0.6974228453503607 1.0070823394566086 0.19953720996079938 0.9975625263986176 0.01448075810633556 0.08972934054293592 0.06370229148211999 0.013683325329657946 0.04997349873924557 1.1592729319349166e-07 6.93581430443428 -0.8075451294958093 down GALAK(ub)LVEAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GALAKLVEAIR 11 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 12075490.0 993090.0 4443700.0 6638700.0 True False 1301950.607097239 3780717.2814069353 5951791.006907064 1.0 2.9038868761974195 4.571441477474223 20.312243286454798 -7.223935982996775 0.20765995717129113 1.506512724610817e-13 7.10370659611275 0.9999841651953356 0.005806183713136286 0.09809803865798929 0.010958183802101593 0.09278330101811237 0.2515246553968269 5.97123298816389e-08 7.223935982996775 7.103706596112599 GALAK(ub)LVEAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GALAKLVEAIR 11 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 30163600.0 5064700.0 10848700.0 14250200.0 True False 4903923.870776621 15180642.485223116 10517645.12316358 1.0 3.095611368620003 2.1447407015920765 22.225505151920252 -10.04960722952203 7.829519714647141 0.9999999418761809 2.6201760351060397 0.7947022466391525 0.38819132426638403 3.973672347624316e-07 4.864356622122925e-08 0.37586465030851013 0.1252882111688257 8.920573388892005e-11 10.04960722952203 1.6201760932298588 GALAK(ub)LVEAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GALAKLVEAIR 11 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 15572590.0 993090.0 3937300.0 10642200.0 True False 1360262.210248147 3763337.0670900373 8128731.542988933 1.0 2.7666261980500857 5.97585633251257 20.37545334797769 -6.961881422540838 0.40805265561611503 0.8385140010404889 8.022689586998773 0.9998337392941337 0.026557510932341395 0.07903575697174518 0.01869751089441069 0.04130566087492719 0.2681180617858578 1.091738378208507e-07 6.961881422540838 7.184175585958284 GALAK(ub)LVEAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GALAKLVEAIR 11 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 27578200.0 5064700.0 9757100.0 12756400.0 True False 4211522.454253032 9704536.565667285 15423704.26107047 1.0 2.304282280595963 3.662263333178895 22.00591042735453 -6.970617737260683 0.24298195989802565 0.5300683176965957 5.475900489371112 0.9999868071566896 0.0039479675071382656 0.07610279119210216 0.008309827440888606 0.03178709095092334 0.13169702008313117 1.0699962675342539e-07 6.970617737260683 4.945832171674516 GALAK(ub)LVEAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GALAKLVEAIR 11 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 13508500.0 6228700.0 2866800.0 4413000.0 True False 8063174.936032745 2707260.0598802655 3609879.281203779 1.0 0.33575608632550585 0.4476994868450562 22.942916592017237 -9.912378915043393 5.67037523390582 1.00000041388368 0.39172778658770246 0.9752275885771708 0.045700701894375216 2.3907237059375544e-07 4.5990051863544614e-08 0.04424954433513862 0.014749838111724319 1.2235482070362106e-10 9.912378915043393 -0.6082726272959775 GALALAQAVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GALALAQAVQR 11 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 11551900.0 1830400.0 4751200.0 4970300.0 False True 2399672.125618815 4042339.4800325464 4456021.034484188 1.0 1.6845382487368474 1.8569291141534983 21.194405868883987 -11.119596285587686 0.25812914837882767 1.3071006937412574e-15 1.9331991503038037 0.9992472596386168 0.010153579687119014 3.1734052132885404 0.1380993116826421 1.9298186752969957 0.07561684361412502 7.592830665773236e-12 11.119596285587686 1.9331991503038024 GALALAQAVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GALALAQAVQR 11 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 6311900.0 2520700.0 1081600.0 2709600.0 False True 2440681.75826142 1513488.5204694867 1999874.4737424063 1.0 0.6201089164314465 0.8193917404319786 21.218852762964513 -10.122001041397164 4.885240193880607 1.0000143982341176 0.7197503284302879 0.7250385188458655 0.08135687222194861 113509550.57735889 2.1891482856129274 18384.109275525538 0.027850621326772334 7.550904170277344e-11 10.122001041397164 -0.2802640698038298 GALALAQAVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GALALAQAVQR 11 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 7838400.0 1830400.0 2794300.0 3213700.0 False True 2507148.3447000883 2670838.5864855843 2454690.248229085 1.0 1.0652894122246592 0.9790765885146384 21.257615930406878 -6.704169796961799 1.8158632775260175 1.0403750153075533 0.979310824275498 0.4374446088576204 0.027538997377278787 0.38691361496412185 2.483074903382697 0.0120855745208987 0.03092349624337124 1.9761968515096765e-07 6.704169796961799 -0.06106419103205529 GALEALLCGGPQGACSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GALEALLCGGPQGACSEK 18 0 Q8WU39;Q8WU39-3 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 110053000.0 17846000.0 39878000.0 52329000.0 False True 23396278.820909835 33928357.84322653 46914497.05521259 1.0 1.4501604337568381 2.0052119148658774 24.479775751561704 -6.968309641134269 0.2957896297887351 0.8987895001784256 2.5738714717638906 0.9999660309185194 0.002396124286714897 0.07685511331695434 0.010983086991187432 0.009406341293243192 0.05000684783013796 1.0756979943162365e-07 6.968309641134269 1.675081971585465 GALEALLCGGPQGACSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GALEALLCGGPQGACSEK 18 0 Q8WU39;Q8WU39-3 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 159613800.0 5646600.0 145020000.0 8947200.0 False True 8566305.02175527 119140047.95356825 7178781.99830293 1.0 13.907985724416333 0.838025494080757 23.030241617734436 -6.64901982438555 2.0120972817619895 9.38245895749398 0.8927997417886682 0.19014300845884746 5.510589348357699 0.5108546558184466 3.963197672447465 2.22202331812593 6.103163946912081 2.2437794988914163e-07 6.64901982438555 -8.489659215705313 GALEALLCGGPQGACSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GALEALLCGGPQGACSEK 18 0 Q8WU39;Q8WU39-3 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 138957000.0 17846000.0 49708000.0 71403000.0 False True 24444148.47001626 47511736.197625674 54539081.99094542 1.0 1.9436854695881363 2.2311712783877207 24.542985813084595 -10.469179837114375 0.2560830032178441 1.4837386330835333e-11 2.372223258864894 0.9991365306169013 0.01545298153079472 2.0867442696727867 0.12593775388665723 1.4777214619978092 0.12636717076603168 3.3948466618729156e-11 10.469179837114375 2.3722232588500565 GALEALLCGGPQGACSEK(ub)VSATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GALEALLCGGPQGACSEKVSATR 23 1 Q8WU39;Q8WU39-3 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 1 60297800.0 57131800.0 3166000.0 0.0 True False 47507623.067880206 3148944.1295982017 0.0 1.0 0.06628292316580232 0.0 25.501655690914703 -12.742527309520316 0.4052992369516397 6.084411462912219 2.0828020904946184e-82 0.9997470835905123 0.007261211868444747 11.044718155425517 0.23305998893277433 47.74823364708029 0.0171957049865645 1.809142143306231e-13 12.742527309520316 -6.084411462912219 GALEALLCGGPQGACSEK(ub)VSATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GALEALLCGGPQGACSEKVSATR 23 1 Q8WU39;Q8WU39-3 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 1 111983000.0 69591000.0 23813000.0 18579000.0 True False 90086921.34369202 22487785.61669067 15197812.636638362 1.0 0.24962320036331542 0.1687016540243056 26.424814337595755 -13.999999999999998 0.3145393550964858 8.449295596147207 0.1516389626619488 0.9996819265677717 0.0066748742625386565 17.599353401256725 0.17862418510202258 86.0190525917154 0.027530776163717078 1.0000000000000041e-14 13.999999999999998 -8.297656633485259 GALINVPPPFLGLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GALINVPPPFLGLPR 15 0 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 12067700.0 2314400.0 5437700.0 4315600.0 False True 3034200.8126814845 4626416.355988586 3869063.110158332 1.0 1.5247561521480104 1.2751506406522366 21.532885140035198 -10.034098913426103 4.324988556121302 0.9999746953958482 1.3999533964163275 0.7739261413024967 0.10190102362147292 13182552.406460986 7645976.666089652 3037.049598758113 0.034883430562537204 9.24487591825827e-11 10.034098913426103 0.3999787010204794 GALINVPPPFLGLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GALINVPPPFLGLPR 15 0 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 17577700.0 5605200.0 5073200.0 6899300.0 False True 5427265.994131356 7098955.216388505 5092166.355436596 1.0 1.3080168217413317 0.9382562713791601 22.371794187237978 -6.685636694754733 1.8818485975796975 1.1938951483787248 0.9395968139838882 0.35002998107415617 0.13038793693449854 0.4261658220938176 2.9225164181785592 0.05549936555037852 0.14532795160770312 2.0623544363936507e-07 6.685636694754733 -0.2542983343948366 GALINVPPPFLGLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GALINVPPPFLGLPR 15 0 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 16832800.0 2314400.0 5983500.0 8534900.0 False True 3170096.224308287 5719129.185211509 6519132.401783122 1.0 1.804086936338792 2.0564462213463544 21.59609520155809 -10.675926798297894 0.2387004372026554 4.673962204977315e-15 2.1984047939354032 0.9992166100727574 0.012608286962421346 2.436059326547272 0.12242107832992584 1.5332660565838927 0.12233556835971689 2.108983595800948e-11 10.675926798297894 2.1984047939353983 GALINVPPPFLGLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GALINVPPPFLGLPR 15 0 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 8314900.0 5605200.0 0.0 2709700.0 False True 4660972.152462942 0.0 3276285.7417627727 1.0 0.0 0.7029189693895778 22.152199462672254 -10.539145682059223 8.5293568043985 1.0000760582274328 0.35145948704376234 0.5316196932468213 0.2869654675879156 0.00041509130729264204 2.242780439721763e-05 0.27788508335759665 0.0926177064087185 2.8897103798922565e-11 10.539145682059223 -0.6486165711836704 GALLSVGWSTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GALLSVGWSTGR 12 0 Q9NRG9-2;Q9NRG9;F8VZ44 Q9NRG9-2;F8VZ44 AAAS Aladin 0 8945800.0 3020000.0 3399600.0 2526200.0 False True 3959249.245721599 2892392.931537013 2264813.0570214996 1.0 0.730540754579308 0.5720309372967305 21.9167954612054 -11.409563244226174 0.07728664741579219 2.0753237619524163 7.102573177240238e-09 0.9999484396525484 0.0012685313519339768 4.260663869060808 0.05193927586604036 1.1790791490864625 0.38831707904532353 3.894365917877234e-12 11.409563244226174 -2.075323754849843 GALLSVGWSTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GALLSVGWSTGR 12 0 Q9NRG9-2;Q9NRG9;F8VZ44 Q9NRG9-2;F8VZ44 AAAS Aladin 0 14013100.0 4779500.0 4259700.0 4973900.0 False True 4627777.388666033 5960620.424042044 3671086.376198465 1.0 1.2880093235772965 0.7932720327450029 22.14188803705569 -6.748885573494205 1.6538750325908038 1.1695783003531683 0.7923662500079457 0.6441975592163669 0.12101758464632803 0.3019943924826917 1.6248829843241535 0.05781031920311728 0.14051761594966805 1.7828484447142e-07 6.748885573494205 -0.37721205034522265 GALLSVGWSTGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GALLSVGWSTGR 12 0 Q9NRG9-2;Q9NRG9;F8VZ44 Q9NRG9-2;F8VZ44 AAAS Aladin 0 61856000.0 12803000.0 19335000.0 29718000.0 False True 19423087.024675496 15884518.184955504 23844224.27413791 1.0 0.8178163525074814 1.2276227895105298 24.211269179142203 -6.785902326695822 1.5131390887783027 0.8976309951472001 1.2314742087935024 0.7876169302656733 0.0772593707839554 0.2415209221782592 1.0925388859851928 0.040203431373864645 0.09439566360794499 1.6371846846530616e-07 6.785902326695822 0.3338432136463023 GALLSVGWSTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GALLSVGWSTGR 12 0 Q9NRG9-2;Q9NRG9;F8VZ44 Q9NRG9-2;F8VZ44 AAAS Aladin 0 17620800.0 3020000.0 6681400.0 7919400.0 False True 4136575.6124313045 6386193.655564831 6049000.825162709 1.0 1.5438358328016384 1.4623208643845775 21.98000552272829 -10.647730942259615 6.428156848185817 0.9972635036678514 1.5030783485931078 0.9806893796956834 0.03327834650348088 0.0013100489355285204 7.179182983541293e-05 0.032343721210911586 0.010740540149775114 2.2504483906071764e-11 10.647730942259615 0.5058148449252564 GALLSVGWSTGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GALLSVGWSTGR 12 0 Q9NRG9-2;Q9NRG9;F8VZ44 Q9NRG9-2;F8VZ44 AAAS Aladin 0 15260600.0 4779500.0 6262000.0 4219100.0 False True 3974366.017750778 6228265.3630903205 5101294.303085694 1.0 1.567109152824102 1.2835491950921727 21.922293312489966 -10.083738506683382 4.54541038207109 0.9999717650666102 1.4253291739764236 0.7499905101783301 0.11576286804779572 13586304.406080676 30140457.322138816 2287.760740120373 0.03962871321685218 8.246344867387797e-11 10.083738506683382 0.42535740890981333 GALLSVGWSTGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GALLSVGWSTGR 12 0 Q9NRG9-2;Q9NRG9;F8VZ44 Q9NRG9-2;F8VZ44 AAAS Aladin 0 35407890.0 12803000.0 21702000.0 902890.0 False True 16573735.884859951 20494264.622408774 738573.2844337369 1.0 1.2365506947127238 0.04456287282268212 23.982395501234652 -6.86184853367795 1.2228994016217383 1.1264579737974196 5.117495594720358e-13 0.9473956358467565 0.11818351409842258 0.14891572967719532 0.4294807828291695 0.07600687380696465 0.17250368605244096 1.3745212750952279e-07 6.86184853367795 -1.1264579737969078 down GALNPADITVLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GALNPADITVLFK 13 0 X6RLT1;H0UI80;Q8IXH7-4;Q8IXH7 X6RLT1 NELFCD;TH1L Negative elongation factor C/D 0 3527450.0 737050.0 1381700.0 1408700.0 False True 966279.6876023526 1175555.745824416 1262941.2372045706 1.0 1.216579175684986 1.3070141630921888 19.88208130895811 -13.867307907266875 0.12090888943233115 1.6338092411903506e-15 1.4504952522811945 0.9996909671757112 0.002264496594857421 11.44997553277997 0.10599859119563691 2.768798465829535 0.12638959966217453 1.3573507671776425e-14 13.867307907266875 1.450495252281193 GALNPADITVLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GALNPADITVLFK 13 0 X6RLT1;H0UI80;Q8IXH7-4;Q8IXH7 X6RLT1 NELFCD;TH1L Negative elongation factor C/D 0 5391450.0 737050.0 2412400.0 2242000.0 False True 1009557.3030273156 2305812.1912600026 1712485.775439401 1.0 2.283983469136089 1.696273971080437 19.945291370481 -10.180689910520176 5.355297287015844 0.9999594469026551 1.990128720108499 0.7909872232417496 0.23993139787144302 0.0001161803035081293 1.777389611087304e-05 0.23232203082455805 0.07743752568224122 6.596447183580625e-11 10.180689910520176 0.9901692732058438 GALPLDTVTFYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GALPLDTVTFYK 12 0 P30040;P30040-2 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 94450000.0 14963000.0 39098000.0 40389000.0 False True 19616637.9018981 33264730.802810315 36209933.718645066 1.0 1.6957406752964344 1.8458786821538569 24.22557446326628 -11.16794134124324 0.28199910894328417 2.310935836320021e-23 1.8981794392650693 0.9992667886072184 0.009978101921103202 3.226265665579004 0.1486823817116454 2.1031763102283745 0.05857760198852724 6.792953766596976e-12 11.16794134124324 1.8981794392650693 GALPLDTVTFYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GALPLDTVTFYK 12 0 P30040;P30040-2 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 114659000.0 5336800.0 106180000.0 3142200.0 False True 8096315.772341502 87231349.41187356 2521142.792724816 1.0 10.774202966474189 0.31139383191272035 22.948834128416067 -6.661574216086763 1.9678323932074926 7.283837056547997 0.3556742091662086 0.24195078562782357 4.160176907683088 0.48083727917933605 3.5811889474845273 1.707237785567169 4.6110330537649595 2.17984585399296e-07 6.661574216086763 -6.928162847381788 GALPLDTVTFYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GALPLDTVTFYK 12 0 P30040;P30040-2 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 84825000.0 14963000.0 29053000.0 40809000.0 False True 20495225.459870722 27769342.394576695 31170754.687737092 1.0 1.3549176343021236 1.5208788382820604 24.288784524789172 -11.78501164424543 0.1272728504057169 3.1929930493365477e-12 1.7954227743564333 0.9997297733636645 0.0035714698516877553 4.995487265823107 0.08693391343508013 1.5641321077971906 0.20483619684157608 1.640545786516155e-12 11.78501164424543 1.7954227743532403 GALPLDTVTFYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GALPLDTVTFYK 12 0 P30040;P30040-2 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 45445400.0 28805000.0 8036900.0 8603500.0 False True 23952633.777866095 7993603.62450025 10402452.071910549 1.0 0.333725455773757 0.4342926196919163 24.51368096440486 -10.82078521401928 7.380931393103857 1.0292955934143686 0.3840090377328524 0.9804012287549017 0.04105637274638762 0.016614859523730065 0.00040342127835243886 0.03337082742653002 0.013250887325203603 1.5108271686391254e-11 10.82078521401928 -0.6452865556815162 GALPLDTVTFYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GALPLDTVTFYK 12 0 P30040;P30040-2 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 19651200.0 5336800.0 7263400.0 7051000.0 False True 6908592.804055349 6859185.404958248 5767790.349369564 1.0 0.9928484134905015 0.8348719504764945 22.719960450508516 -6.9163702869256865 0.8512255637493261 1.0039620737637704 0.8114096552752001 0.9931115674923495 0.006325366736093942 0.10035448881076785 0.11703322953981979 0.0053476854589082825 0.015502555876010134 1.212354735229964e-07 6.9163702869256865 -0.1925524184885703 GALQNIIPASTGAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GALQNIIPASTGAAK 15 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 341348000.0 23058000.0 133620000.0 184670000.0 False True 30229261.293989625 113684416.84668048 165562119.87972432 1.0 3.7607408180127755 5.4768827550755415 24.849442388776918 -8.373496475921142 0.27958474060037836 1.1774680177595208e-17 6.590741477616371 0.9990716611089184 0.05618997010024392 0.12441212417395905 0.07170330720782062 0.6087028643744009 0.576591909228833 4.231589434223114e-09 8.373496475921142 6.590741477616371 GALQNIIPASTGAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GALQNIIPASTGAAK 15 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 275411000.0 87844000.0 47557000.0 140010000.0 False True 85055440.30337463 66546758.10647872 103337180.7900335 1.0 0.7823927296022525 1.214939108203447 26.341900180496264 -6.769960779136416 1.5748770301021586 0.8751764163295435 1.2173517238354683 0.7302876129456107 0.09170864040951428 0.26650661061885267 1.3045428788398385 0.04590275222291431 0.10925936118034384 1.6983970267114555e-07 6.769960779136416 0.34217530750592484 GALQNIIPASTGAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GALQNIIPASTGAAK 15 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 839392000.0 16232000.0 809010000.0 14150000.0 False True 24625130.718154542 664635844.6760198 11353246.29783467 1.0 26.990144835496288 0.46104308755870455 24.55362804709254 -8.250524338026347 5.849317946857613e-11 8.778556315942179 16.1275113577071 0.0 12.731946988862306 0.0 0.7682477633642041 1480874204.175319 1480874196.7704866 5.616628016787038e-09 8.250524338026347 7.3489550417649205 GALQNIIPASTGAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GALQNIIPASTGAAK 15 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 328008000.0 23058000.0 174880000.0 130070000.0 False True 31583165.719020218 167153223.34917465 99350144.87573719 1.0 5.292478430954455 3.1456677193035754 24.91265245029981 -9.064289869153614 11.294375362547253 1.0000000000221303 4.219073075208623 0.7498668492030987 0.8764318029822344 0.0 0.0 0.8486014442586178 0.2828671480862059 8.62402746303164e-10 9.064289869153614 3.219073075186493 GALQNIIPASTGAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GALQNIIPASTGAAK 15 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 109991900.0 87844000.0 13448000.0 8699900.0 False True 73046178.14903219 13375552.954780983 10519008.866207318 1.0 0.18311092097784448 0.1440049176117873 26.12230545593054 -13.32122404785451 0.44011492499108895 9.999999999967885 0.1436295196302521 0.9998774079335915 0.004369342742183965 18.030799449660705 0.2235799886055386 153.81733910538173 0.009035006352126299 4.772829849731966e-14 13.32122404785451 -9.856370480337633 GALQNIIPASTGAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GALQNIIPASTGAAK 15 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 62490000.0 16232000.0 25689000.0 20569000.0 False True 21012643.98055508 24259384.567554116 16825653.055762637 1.0 1.154513662821468 0.8007394534135234 24.32475436918499 -6.787987130209904 1.504149819414697 1.08658834955672 0.7971732501029937 0.7947501734143614 0.06560649846367177 0.2383966793436393 1.06552806342037 0.03433376820319683 0.08051064349762137 1.6293443155664263e-07 6.787987130209904 -0.28941509945372623 GALQNIIPASTGAAK(ub)AVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GALQNIIPASTGAAKAVGK 19 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 85606400.0 27103400.0 34005000.0 24498000.0 True False 35532819.869698934 28931586.550451852 21963181.9614095 1.0 0.8142215184875781 0.6181097374750966 25.082648849097968 -6.970440651807654 0.2474392192634142 1.0642304910143165 0.3623755588918789 0.9999856160024939 0.0005913369939405304 0.07616002944527504 0.008517177959043809 0.004451032264287886 0.01887513130308901 1.0704326521021587e-07 6.970440651807654 -0.7018549321224377 GALQNIIPASTGAAK(ub)AVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GALQNIIPASTGAAKAVGK 19 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 175354000.0 52102000.0 71744000.0 51508000.0 True False 50448050.52919289 100391753.3400174 38016509.59312223 1.0 1.9900026321517315 0.7535773770112907 25.588295184361666 -6.693497921627718 1.8536254746914078 1.6186447136569757 0.7576318797449931 0.38681250610282647 0.418413978516523 0.40930287831930345 2.7291822979193547 0.1803821489517622 0.4677295984985143 2.0253592994200476e-07 6.693497921627718 -0.8610128339119826 GALQNIIPASTGAAK(ub)AVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GALQNIIPASTGAAKAVGK 19 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 268687400.0 69274400.0 40665000.0 158748000.0 True False 105094329.437021 33408013.032904852 127371388.21827997 1.0 0.3178859716967412 1.2119720340820934 26.647109587164046 -6.702801832009537 1.8210203706982284 0.577600868494776 1.2094447906483194 0.4308377299352415 0.2877838322166398 0.38971300932255326 2.514410669405385 0.1259889401155734 0.32287726496834024 1.9824314002499437e-07 6.702801832009537 0.6318439221535435 GALQNIIPASTGAAK(ub)AVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GALQNIIPASTGAAKAVGK 19 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 166230200.0 52102000.0 92583200.0 21545000.0 True False 43325121.50995937 92084435.92527358 26049959.887175303 1.0 2.1254282207634585 0.601266862718136 25.368700459795942 -6.708876256308638 1.7990695030724604 1.6926757095027467 0.6049425627619547 0.45982433808149725 0.47433305220042965 0.377339805235156 2.3800160266714525 0.209863154258134 0.5339069732228329 1.9548963857967554e-07 6.708876256308638 -1.087733146740792 GALQNIIPASTGAAK(ub)AVGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GALQNIIPASTGAAKAVGK 19 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 173550400.0 69274400.0 54475000.0 49801000.0 True False 89677076.40257299 51443418.362626486 40737729.00141164 1.0 0.5736518230332327 0.4542713772083097 26.418235909256495 -13.999999999999998 0.17857486723706512 3.2025868292746495 0.35803288274560424 0.9994999257296446 0.005238304140596969 12.186639131072907 0.13394753162428186 9.310492833184158 0.0902251914492029 1.0000000000000041e-14 13.999999999999998 -2.8445539465290453 GALQYLVPILTQTLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GALQYLVPILTQTLTK 16 0 Q14974;Q14974-2 Q14974 KPNB1 Importin subunit beta-1 0 264613000.0 89307000.0 48206000.0 127100000.0 False True 74262727.47092137 47946304.70985823 153676022.35599822 1.0 0.6456308075761463 2.069356022725832 26.146134966698995 -6.840827022860207 1.2786793101827734 0.8115071193644097 2.116916520575209 0.9258449570657029 0.16479682477236318 0.16783696307130974 0.532720375699265 0.10104879314187777 0.23283376942267914 1.4426898526609368e-07 6.840827022860207 1.3054094012107993 up GALTVGITNTVGSSISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GALTVGITNTVGSSISR 17 0 Q06210-2;Q06210;A0A6I8PRN4;A0A6I8PTT9 Q06210-2 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 0 6190300.0 1835300.0 1386900.0 2968100.0 False True 1777039.406092428 1940696.4025879535 2190665.568908636 1.0 1.0920953108492932 1.2327613903203982 20.76104424300578 -6.964955482477755 0.35882960086338056 0.9877155751535085 1.3419527232546486 0.9999122043854929 0.0008967923458770963 0.07797622149115155 0.014914201507545844 0.0018917935964120037 0.012023104543346751 1.0840380280595714e-07 6.964955482477755 0.35423714810114015 GALVLGSSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GALVLGSSLK 10 0 P46976-2;P46976;C9JQ42;G5E9W8;P46976-3 P46976-2;P46976-3 GYG1 Glycogenin-1 0 17428200.0 4202800.0 4550000.0 8675400.0 False True 5509911.499973099 3871157.7357610897 7777752.828312992 1.0 0.7025807466744229 1.4115930588632803 22.39359771578389 -6.792752649946866 1.4852332908665435 0.834361447167277 1.4197240904796382 0.8101261024818474 0.12667172745305288 0.23128278024777227 1.0078003948357817 0.06711940590427357 0.15683949021100813 1.611563230894884e-07 6.792752649946866 0.5853626433123612 GALVLGSSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GALVLGSSLK 10 0 P46976-2;P46976;C9JQ42;G5E9W8;P46976-3 P46976-2;P46976-3 GYG1 Glycogenin-1 0 17522500.0 3280600.0 10667000.0 3574900.0 False True 4976910.043985828 8763390.508348588 2868319.4480656707 1.0 1.760809504471233 0.5763253550326454 22.246818880335812 -6.733258462482399 1.7115106750123366 1.4561818822473762 0.5766201378124571 0.5742587494913025 0.3197514734220441 0.3301513629019692 1.8961024530870052 0.147968514053828 0.36580450009977783 1.848168387730752e-07 6.733258462482399 -0.8795617444349191 GALVLGSSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GALVLGSSLK 10 0 P46976-2;P46976;C9JQ42;G5E9W8;P46976-3 P46976-2;P46976-3 GYG1 Glycogenin-1 0 12614500.0 4202800.0 3405300.0 5006400.0 False True 5756688.73639944 3254842.5861787787 3823991.43004452 1.0 0.5654018716694663 0.6642692709552787 22.456807777306782 -10.343899317050074 5.928380871034937 1.0000496628265132 0.614835571312383 0.952910171167217 0.040362446741043036 2.6497335432088796e-05 2.9325475163149576e-06 0.03908579174464171 0.013026923670019994 4.530025878010444e-11 10.343899317050074 -0.3852140915141302 GALVLGSSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GALVLGSSLK 10 0 P46976-2;P46976;C9JQ42;G5E9W8;P46976-3 P46976-2;P46976-3 GYG1 Glycogenin-1 0 7046400.0 3104800.0 2410200.0 1531400.0 False True 2581778.765961419 2397215.7742127557 1851608.6596064153 1.0 0.9285132428146164 0.7171833171836092 21.299933949936353 -6.951780637108028 0.5389393031242514 1.0031332127649768 0.6328218160115813 0.9993337210680854 0.0030993434663310637 0.08277848416625719 0.03306327435300661 0.003413913359397827 0.017498185866767473 1.1174275198290121e-07 6.951780637108028 -0.3703113967533955 GALVLGSSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GALVLGSSLK 10 0 P46976-2;P46976;C9JQ42;G5E9W8;P46976-3 P46976-2;P46976-3 GYG1 Glycogenin-1 0 16470600.0 3280600.0 9291100.0 3898900.0 False True 4246801.370293811 8774042.117466709 3189340.2060923222 1.0 2.0660354352432746 0.7509982050023853 22.017945202428262 -6.691078905424282 1.8628546343321832 1.667663158233156 0.7555144703957778 0.3754066827703264 0.45075948955762807 0.41432595635515546 2.7885551394243526 0.19352703622093448 0.5032230145509823 2.0366720083738747e-07 6.691078905424282 -0.9121486878373782 GALWILGEYCSTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GALWILGEYCSTK 13 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 6875000.0 1558100.0 2986000.0 2330900.0 False True 2042684.1886618624 2540500.439336834 2089720.8275716153 1.0 1.243706909486133 1.023026877659716 20.962034741251244 -10.603102013775452 2.8840439098504596 0.9904487454643027 1.1333668936404888 0.3274947556651868 0.09009224762433328 67042588.20832679 70538090.42492685 4870685.66603081 0.03432676389531516 2.4940088269354382e-11 10.603102013775452 0.1429181481761861 GALWILGEYCSTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GALWILGEYCSTK 13 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 9478700.0 1558100.0 3395700.0 4524900.0 False True 2134171.676069277 3245666.745921731 3456211.813240742 1.0 1.5208086501736395 1.6194628820144414 21.025244802774136 -11.65896321828218 0.28261770220118854 4.2268929301459714e-22 1.6519761610539312 0.9993718689907078 0.00681113275772578 4.295714451966698 0.15490602047637397 2.619862729941314 0.03846667260664286 2.192990658520528e-12 11.65896321828218 1.6519761610539312 GAMSTQQIK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAMSTQQIKK 10 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 2229060.0 472220.0 810970.0 945870.0 True False 619084.9929849843 689976.4371363015 848000.445825717 1.0 1.1145100348976424 1.3697641768652675 19.239777962293964 -6.957869742375569 0.4644835820126057 0.9928837372212717 1.5017579911911179 0.9996828470817489 0.0027524793874209356 0.08047105149391913 0.024010848078702022 0.003493821241994041 0.021077036714358097 1.1018697429669341e-07 6.957869742375569 0.5088742539698462 GAMSTQQIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAMSTQQIKK 10 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 2228220.0 589160.0 670160.0 968900.0 True False 570457.4382898789 937758.3828382307 715116.0236230517 1.0 1.6438709006046954 1.253583485153303 19.121759725790874 -10.12614666779322 4.332493079596958 0.9999295709081265 1.4487271929144427 0.6380118632273599 0.15933417026974162 23502099.116182107 27465227.701350693 13162.420286336868 0.054544324866622675 7.479168750528207e-11 10.12614666779322 0.44879762200631623 GAMSTQQIK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAMSTQQIKK 10 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 1584830.0 472220.0 551670.0 560940.0 True False 646812.4952656655 527295.3952712681 428457.5249219346 1.0 0.8152214113530567 0.6624138031624669 19.302988023816855 -6.973304603333946 0.16071673926629568 1.1531437132216311 0.3204344579726897 0.99999802312451 0.00019397897624360514 0.07524431132584183 0.004964762322373698 0.007024415802962111 0.018288779957956653 1.063396916491902e-07 6.973304603333946 -0.8327092552489415 GAMSTQQIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAMSTQQIKK 10 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 1796940.0 589160.0 726460.0 481320.0 True False 489912.64421342086 722546.4157889796 581961.7866277664 1.0 1.4748474535681027 1.1878888889714923 18.90216500122515 -10.14399444461278 4.376340889500643 0.9999511796236197 1.3313681710430352 0.6400235860324051 0.1171503436471979 61912071.01697632 4.580056456768517 37087.39772009626 0.04287263580541179 7.178034731765048e-11 10.14399444461278 0.3314169914194155 GANEATK(ub)TLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GANEATKTLNR 11 1 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 18360120.0 6250200.0 8144500.0 3965420.0 True False 8194072.727022906 6929372.347012348 3555116.377394582 1.0 0.8456566810983074 0.43386439147291256 22.966149266932437 -6.954053109399954 0.5124195754111354 1.0074304192052788 0.25395001791606014 0.9994821666326746 0.005437692346154453 0.08189789440873897 0.029534094295256552 0.006237313398018087 0.03399199217925086 1.1115957831299241e-07 6.954053109399954 -0.7534804012892187 down GANEATK(ub)TLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GANEATKTLNR 11 1 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 28485500.0 9499000.0 12354300.0 6632200.0 True False 9197459.44448972 17287436.416823406 4895027.85826484 1.0 1.8795882190250335 0.5322152152785512 23.13280397908045 -6.73055507559289 1.7211275461555553 1.5290152580203054 0.532928421705212 0.5618113730253569 0.3697439243229846 0.33522936402169107 1.9457023062671193 0.17022036120846074 0.42213776283453747 1.859708707003507e-07 6.73055507559289 -0.9960868363150933 GANEATK(ub)TLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GANEATKTLNR 11 1 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 10247310.0 2844310.0 1996200.0 5406800.0 True False 4315026.216914386 1639962.5136182143 4338143.610115376 1.0 0.3800585283096909 1.0053574166271282 22.040937894173936 -10.919141607305475 11.116451840636332 1.0387875950169636 0.692707972468869 0.24357464866026035 0.2552772021845478 0.1392748259839091 0.0010130498843279965 0.1402804598596969 0.0823903627272647 1.2046430869447872e-11 10.919141607305475 -0.34607962254809466 GANEATK(ub)TLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GANEATKTLNR 11 1 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 16473070.0 6250200.0 7100600.0 3122270.0 True False 8561067.845304033 6786872.013455797 2384854.131169125 1.0 0.7927599846295543 0.2785697034835764 23.029359328455328 -6.955623705697486 0.49325763947974677 1.0109274927288217 0.038477323890238314 0.9995718951735365 0.006275044233597855 0.08130306435477992 0.02720185143209852 0.007455798208480883 0.04240964054087718 1.1075830332802871e-07 6.955623705697486 -0.9724501688385834 down GANEATK(ub)TLNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GANEATKTLNR 11 1 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 27236100.0 9499000.0 16135200.0 1601900.0 True False 7898839.377050865 16048276.475013547 1936849.8836512477 1.0 2.0317258914822216 0.24520689574705543 22.913209254514726 -6.750103549644169 1.6493452384555294 1.6065852086114398 0.24160295788258532 0.6494645998163567 0.4335411192747134 0.2998644875426334 1.604967493189122 0.20763787075540746 0.5040568287870615 1.7778554621024128e-07 6.750103549644169 -1.3649822507288545 GANEATK(ub)TLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GANEATKTLNR 11 1 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 7922160.0 2844310.0 3160150.0 1917700.0 True False 3682015.3647321807 2984284.8745048945 1568698.2772636528 1.0 0.8105031019396528 0.42604338164616956 21.812064216266386 -6.959763767534754 0.43875022044388284 1.01392714770436 0.20766086607030226 0.9997613373940449 0.0036888437779416666 0.07978561594516545 0.021443918762295996 0.005061115798586263 0.0318625396558917 1.0970747826031029e-07 6.959763767534754 -0.8062662816340578 down GANFLTQILLRPGASDLTGSFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GANFLTQILLRPGASDLTGSFR 22 1 Q5QPK2;H0Y368;O60762;Q5QPJ9 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 0 58499000.0 13043000.0 21675000.0 23781000.0 False True 19787184.57102575 17806926.902452055 19080674.926417414 1.0 0.8999222116989106 0.9642945846048824 24.238063016648837 -10.028739552003563 4.794321944546829 1.0000014972032996 0.9321083981503845 0.5972783469071075 0.026279911197169034 4.205754376100957e-07 8.517993577195937e-08 0.025445975770396492 0.008481804866464396 9.359668086074902e-11 10.028739552003563 -0.06789309905291507 GANFLTQILLRPGASDLTGSFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GANFLTQILLRPGASDLTGSFR 22 1 Q5QPK2;H0Y368;O60762;Q5QPJ9 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 0 31890300.0 13043000.0 12127000.0 6720300.0 False True 16884420.615967236 11452121.789510265 5497274.356101013 1.0 0.678265606501193 0.32558264693443834 24.009189338741287 -7.209341379333456 0.29374082816435665 1.0766616275532013 4.992431122964962e-14 0.9999240885595001 0.0023997049223641684 0.09124913310338736 0.016090661632284998 0.010259684297867383 0.0407417143385012 6.175307961597978e-08 7.209341379333456 -1.0766616275531513 down GANLK(ub)DYYSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GANLKDYYSR 10 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 5164660.0 965460.0 1670300.0 2528900.0 True False 1249807.0020617738 1577346.3366882969 2068666.1487052436 1.0 1.2620719311751254 1.655188477334996 20.253273897278966 -6.9652570996824 0.3536163734657131 0.9635563683648708 1.9670431222116498 0.9999183423236044 0.0024331247603940993 0.07787386731808263 0.01455321332383343 0.005348546427456926 0.03370995288161116 1.0832854258015649e-07 6.9652570996824 1.0034867538467789 GANPVEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GANPVEIR 8 0 P10809;E7ESH4;E7EXB4;P10809-2 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 40916700.0 12252000.0 3670700.0 24994000.0 False True 11863066.966405716 5136429.652447618 18447321.59607239 1.0 0.4329765369270151 1.5550212814537943 23.499973703202947 -6.7693566143232715 1.5772415990704367 0.6744927299211346 1.5611277028076271 0.7279480363077289 0.23892894471909543 0.2674869305766194 1.3131952863637184 0.11941896291790746 0.28439718129424396 1.7007613804602292e-07 6.7693566143232715 0.8866349728864925 GANPVEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GANPVEIR 8 0 P10809;E7ESH4;E7EXB4;P10809-2 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 141968560.0 1470600.0 139600000.0 897960.0 False True 2231007.715261096 114687289.30022176 720477.8124101514 1.0 51.40604782121959 0.32293828814744074 21.089264072036517 -6.2373473075203 22.739171660712657 9.999999999999998 0.32289829547888727 0.0 24.46399256167538 2802.876629937804 5036713.585880669 10.565047959999218 115.8747689127391 5.789655095634334e-07 6.2373473075203 -9.67710170452111 GANPVEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GANPVEIR 8 0 P10809;E7ESH4;E7EXB4;P10809-2 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 13976680.0 12252000.0 997920.0 726760.0 False True 10188080.855629759 992544.0068883885 878722.1558414261 1.0 0.09742207791175173 0.08625001786826803 23.280378978637223 GANPVEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GANPVEIR 8 0 P10809;E7ESH4;E7EXB4;P10809-2 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 5696300.0 1470600.0 2119200.0 2106500.0 False True 1903720.6898598038 2001264.6570734829 1723138.6145152436 1.0 1.0512385917394544 0.9051425577783373 20.860390394128967 -6.81195441921103 1.4063919732815369 1.0278609976417878 0.9024731864232152 0.8648372403857026 0.022250996561968696 0.20415525455466235 0.7955033199303201 0.012439277216454556 0.028748751542798344 1.5418622685233344e-07 6.81195441921103 -0.12538781121857268 GAPAAATAPAPTAHKAK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAPAAATAPAPTAHKAK 17 1 Q92522 Q92522 H1FX Histone H1x 1 3058900.0 1049900.0 1020600.0 988400.0 True False 1016571.4991862036 1428130.902358689 729508.3886355908 1.0 1.404850424689214 0.7176164088995063 19.95528025808652 -6.7470899628163545 1.6608626269295423 1.2388879600214975 0.7165679331563843 0.636266688145567 0.17010107803461152 0.3051411296115689 1.6551972368529564 0.08094162291460257 0.1970894482288577 1.790234973747775e-07 6.7470899628163545 -0.5223200268651131 GAPAAATAPAPTAHKAK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAPAAATAPAPTAHKAK 17 1 Q92522 Q92522 H1FX Histone H1x 1 1325970.0 455830.0 471300.0 398840.0 True False 624362.6693425698 450476.4076193171 304642.2063676413 1.0 0.7214979846467305 0.487925081569047 19.25202475556371 -7.009970806164 0.16897234012545845 1.2117373911941203 3.255392026741999e-12 0.9999977000523369 0.0003173960498690959 0.07239409744438152 0.0052121901394755026 0.009976370523602014 0.026510028472329614 9.773029143119566e-08 7.009970806164 -1.2117373911908649 down GAPNNSCSEIK(ub)MNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAPNNSCSEIKMNK 14 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77;A0A0D9SF91;A0A0D9SES7 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 5227900.0 1695100.0 2313800.0 1219000.0 True False 2222292.5153717487 1968590.059121761 1092869.5734736773 1.0 0.8858375058660772 0.4917757522532358 21.08361729725768 -6.948262431945217 0.5776057434623728 1.0047538526088213 0.3534485199435133 0.9990577686122137 0.0066830189528288815 0.08419108381474202 0.03890862388984342 0.007020328862758685 0.03289700617926543 1.1265165281974561e-07 6.948262431945217 -0.651305332665308 down GAPPSSNIEDFHGLLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAPPSSNIEDFHGLLPK 17 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;H0Y8T4;D6R991 P43243 MATR3 Matrin-3 0 10733900.0 1024600.0 5256400.0 4452900.0 False True 1343260.522240514 4472165.609286725 3992156.6232329267 1.0 3.3293359964359714 2.9719898390031907 20.35730770856016 -9.915815568251732 6.100149099036501 0.999999476577515 3.1506629177200876 0.9797141054338939 0.14588595787756928 1.0388550920535736e-06 1.8425541351735334e-07 0.14125350499512068 0.04708449044184696 1.2139042494878856e-10 9.915815568251732 2.1506634411425725 GAPPSSNIEDFHGLLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAPPSSNIEDFHGLLPK 17 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;H0Y8T4;D6R991 P43243 MATR3 Matrin-3 0 8514200.0 3100000.0 1271900.0 4142300.0 False True 3001592.1968542053 1779776.3028708778 3057307.363663703 1.0 0.5929440730610102 1.0185618708856885 21.51729655176559 -10.98948538214072 12.191155552463394 1.1446002488748013 0.8057529719671642 0.21735622253847053 0.173757738352919 0.06885088076238387 5.9382424422202646e-05 0.016962105205515738 0.05608006890962676 1.0245062634479277e-11 10.98948538214072 -0.33884727690763705 GAPPSSNIEDFHGLLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAPPSSNIEDFHGLLPK 17 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;H0Y8T4;D6R991 P43243 MATR3 Matrin-3 0 9734100.0 1024600.0 4992200.0 3717300.0 False True 1403422.3087738794 4771628.097002231 2839350.300196651 1.0 3.3999944757690463 2.0231617257654193 20.420517770083052 -9.99626260148338 6.071185819347406 0.9999986211748803 2.711578100767382 0.6732545777637569 0.5620896164441705 1.049074835773231e-05 1.7351924020588346e-06 0.5442413686138636 0.18141364363028792 1.0086428134071865e-10 9.99626260148338 1.7115794795925017 GAQDMK(ub)CVSIQYLEAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAQDMKCVSIQYLEAVR 17 1 Q03154;A0A1B0GV31;A0A1B0GU86;A0A1B0GW23;Q03154-4;C9JMV9;A0A1B0GVA5;Q03154-3;F8WC59;C9JYZ0 Q03154 ACY1;ABHD14A-ACY1 Aminoacylase-1 1 7842700.0 1094100.0 2307400.0 4441200.0 True False 1434375.695279473 1963144.9141747532 3981667.2269986053 1.0 1.3686406710846108 2.7758886602040613 20.451991517162867 -6.945948970107052 0.6016775196551658 0.9842060204569135 3.2325687073847136 0.9988438079032613 0.02601956332954102 0.08515437535228934 0.043017114679363026 0.02666098897465876 0.11832660785293751 1.132533428855347e-07 6.945948970107052 2.2483626869278 up GAQDMK(ub)CVSIQYLEAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAQDMKCVSIQYLEAVR 17 1 Q03154;A0A1B0GV31;A0A1B0GU86;A0A1B0GW23;Q03154-4;C9JMV9;A0A1B0GVA5;Q03154-3;F8WC59;C9JYZ0 Q03154 ACY1;ABHD14A-ACY1 Aminoacylase-1 1 50601500.0 3495700.0 7966800.0 39139000.0 True False 5303232.469902229 6545062.29510749 31403159.494766917 1.0 1.234164697145203 5.921512902364975 22.338440560462487 -6.917280833082943 0.8446456430588647 0.8860978624816657 6.6320618034206875 0.9933917096826617 0.18427514198698972 0.09979829019325596 0.11409886641181889 0.15652683617847224 0.4573497894867104 1.2098155629157928e-07 6.917280833082943 5.7459639409390215 up GAQDMK(ub)CVSIQYLEAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAQDMKCVSIQYLEAVR 17 1 Q03154;A0A1B0GV31;A0A1B0GU86;A0A1B0GW23;Q03154-4;C9JMV9;A0A1B0GVA5;Q03154-3;F8WC59;C9JYZ0 Q03154 ACY1;ABHD14A-ACY1 Aminoacylase-1 1 14131100.0 1094100.0 2627000.0 10410000.0 True False 1498618.3369407607 2510930.453672704 7951372.400679831 1.0 1.6754969506101534 5.3058021543440805 20.515201578685758 -6.938208463060109 0.676023572671818 0.9577123560808626 6.235257680902829 0.9979197255732876 0.08623839400170134 0.08859350477264001 0.058403076322018 0.08284819799287851 0.31499901582773804 1.1528997285776426e-07 6.938208463060109 5.277545324821967 GAQDMK(ub)CVSIQYLEAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAQDMKCVSIQYLEAVR 17 1 Q03154;A0A1B0GV31;A0A1B0GU86;A0A1B0GW23;Q03154-4;C9JMV9;A0A1B0GVA5;Q03154-3;F8WC59;C9JYZ0 Q03154 ACY1;ABHD14A-ACY1 Aminoacylase-1 1 21577700.0 3495700.0 5279000.0 12803000.0 True False 4525252.560548701 4985219.009386053 10472985.36987355 1.0 1.10164437071366 2.3143427310946967 22.109566882554937 -6.923474954244025 0.7985101613470624 0.9764447666282831 2.5264506762351604 0.9950935595331234 0.041822569237610595 0.0961695735484728 0.09532678939225177 0.03671454635641084 0.11391680980772487 1.192683045885123e-07 6.923474954244025 1.5500059096068775 up GAQGGDYFYSFGGCHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAQGGDYFYSFGGCHR 16 0 Q9BYN0 Q9BYN0 SRXN1 Sulfiredoxin-1 0 4748400.0 1330600.0 1829600.0 1588200.0 False True 1744429.4855487293 1556630.8117249438 1423868.2990901535 1.0 0.892343786103391 0.8162372345146759 20.734323850487733 -6.974857976052988 0.08103054448435415 1.2621049875641925 0.4445652691216817 0.9999998882066364 2.4536418338727263e-05 0.07475580909500118 0.0023518141307198944 0.009010977350977743 0.014617544049340361 1.0596001813318132e-07 6.974857976052988 -0.8175397184425108 GAQLAK(ub)DIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAQLAKDIAR 10 1 P09661;H0YMA0;H0YLR3 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 1 2319190.0 0.0 2018400.0 300790.0 True False 0.0 2007526.4785789708 363683.79830417543 0.0 GASDEEIK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 GASDEEIKR 9 1 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 10016700.0 3297600.0 3454600.0 3264500.0 True False 4323185.534003826 2939187.1459253277 2926720.8552951794 1.0 0.6798660670025102 0.6769824779147656 22.043663321644853 GASDEEIK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 GASDEEIKR 9 1 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 12486700.0 3348000.0 4936000.0 4202700.0 True False 3241719.572602548 6906970.54089995 3101886.7917025466 1.0 2.130650226279391 0.9568646276248566 21.628327864154336 -6.654666228259938 1.991686931192611 1.7309442807637667 0.9617720302202127 0.2132778918640409 0.4820223486566769 0.4971882512218884 3.785447383810253 0.19591277051717407 0.5341309623457713 2.2147962103683746e-07 6.654666228259938 -0.769172250543554 GASDEEIK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GASDEEIKR 9 1 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 9823100.0 3297600.0 3244100.0 3281400.0 True False 4516811.834289231 3100764.9351958944 2506400.9025543476 1.0 0.6864941575950846 0.5549048741696712 22.106873383167745 -13.999999999999998 0.11891816688969435 2.4954904450861077 0.3417860386959668 0.9996982659971122 0.0032430622285390905 11.968045822379588 0.10598828042274572 4.236049526872389 0.18910924249343575 1.0000000000000041e-14 13.999999999999998 -2.153704406390141 GASDEEIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GASDEEIKR 9 1 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 10009700.0 3348000.0 3897400.0 2764300.0 True False 2784010.341548196 3876403.932626668 3342302.3493208936 1.0 1.3923812978622014 1.2005351774168447 21.408733139588612 -10.168513118581327 4.343999644909867 0.9999335705130432 1.296458237645913 0.7609886837382311 0.07832085082682944 54887902.36968059 5.445154400745892 39770.21837478097 0.026811310431447227 6.784016279483539e-11 10.168513118581327 0.29652466713286985 GASK(ub)EILSEVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GASKEILSEVER 12 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 27257200.0 8636600.0 11448000.0 7172600.0 True False 11322666.236953365 9740003.023954498 6430448.156437493 1.0 0.8602216845504473 0.5679270254783876 23.432710385093724 -6.959164023904736 0.4470596810441286 1.009714369176135 0.4069035724855933 0.9997379255288187 0.0029142686325652274 0.08000110682301381 0.022244991629749637 0.0038901458100099114 0.024188567153156544 1.0985908463803664e-07 6.959164023904736 -0.6028107966905417 GASK(ub)EILSEVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GASKEILSEVER 12 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 38072000.0 10235000.0 10216000.0 17621000.0 True False 9910095.527355747 14295302.075736219 13005531.481331175 1.0 1.4424989180251173 1.3123517775818418 23.240467533514764 -9.950729964534323 4.894040616678232 0.9999975655151394 1.377425347740505 0.9181217281680469 0.05313234763880248 7095635.932836206 14432034.834249897 124.65926235392132 0.018188615375451304 1.1201341435866761e-10 9.950729964534323 0.37742778222536555 GASK(ub)EILSEVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GASKEILSEVER 12 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 30490600.0 8636600.0 10703000.0 11151000.0 True False 11829784.41533914 10230106.069912042 8517363.46205386 1.0 0.8647753594433328 0.7199931260801156 23.495920446616616 -6.970256448179854 0.2519852268120242 1.0448394352286008 0.5356778217882856 0.9999843120203651 0.00045281999418812264 0.07621960534318889 0.00873188689997359 0.0031862271968361774 0.01383144850759921 1.0708867665518203e-07 6.970256448179854 -0.5091616134403152 GASK(ub)EILSEVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GASKEILSEVER 12 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 30235500.0 10235000.0 12961000.0 7039500.0 True False 8510855.987379257 12891176.520442916 8511426.903029507 1.0 1.5146744980245506 1.0000670808730752 23.02087280894904 -10.760308017639804 3.9123440888944017 0.9702969152708695 1.2573707894420667 0.2500977649613063 0.21008759831397456 0.05667505888000782 0.003472227492266432 0.21180551897133165 0.06780548079264165 1.736568753373993e-11 10.760308017639804 0.28707387417119723 GASNK(ub)YLVEFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GASNKYLVEFR 11 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 1245480000.0 150390000.0 181180000.0 913910000.0 True False 197162746.37883177 154148650.23410863 819347360.0437487 1.0 0.7818345659373442 4.155690540389618 27.554811741383823 -6.89146540977078 1.0136932240276897 0.8250354557675985 4.454322184946636 0.9818190967134941 0.20786459652148181 0.11796145649303179 0.2149765712200873 0.15593722874364144 0.3908546450783824 1.283910025912969e-07 6.89146540977078 3.6292867291790376 up GASNK(ub)YLVEFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GASNKYLVEFR 11 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 1848870000.0 256270000.0 320260000.0 1272340000.0 True False 248134849.12510568 448141488.1338374 939075984.6181782 1.0 1.806040101638007 3.7845388825038073 27.886549126853502 -6.9558537740989115 0.49039507606835325 0.9568566492952233 4.717674919931069 0.9995841553730972 0.023856741010167316 0.08121696111687901 0.02686813295064126 0.028510467173073456 0.16318054136598145 1.1069964442611513e-07 6.9558537740989115 3.7608182706358457 GASNK(ub)YLVEFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GASNKYLVEFR 11 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 3668030000.0 295160000.0 1787170000.0 1585700000.0 True False 447779299.0864037 1468235550.2770581 1272285699.962999 1.0 3.278926813438391 2.841323175409898 28.73821259279251 -9.963384756280885 5.411913602473461 0.9999952794019284 3.0601249944215785 0.9672672529701565 0.17865093714591804 1.0899278605525825e-05 2.087058955035035e-06 0.1729784532452994 0.057659342026309755 1.0879658002696094e-10 9.963384756280885 2.06012971501965 GASNK(ub)YLVEFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GASNKYLVEFR 11 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 1430940000.0 150390000.0 231770000.0 1048780000.0 True False 205993247.1369353 221529635.03910273 801079764.3021132 1.0 1.0754218311430352 3.88886420033755 27.618021802906714 -6.9126491643021115 0.8775129053103393 0.9200183260110273 4.2738196062660805 0.9918832023032734 0.12112132258755114 0.10269187661496786 0.12946224154798758 0.10048130831279026 0.2827343941869745 1.2227870641943796e-07 6.9126491643021115 3.353801280255053 up GASNK(ub)YLVEFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GASNKYLVEFR 11 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 1649000000.0 256270000.0 402750000.0 989980000.0 True False 213099859.6859484 400580305.8103846 1196980240.8496552 1.0 1.87977742641751 5.616992158576174 27.66695440228778 -6.943495262094187 0.6262017488375374 0.9592156715741621 6.737662425762399 0.998586814204693 0.07524464070579306 0.08620762127373435 0.04761548003371176 0.07535401209896576 0.3170373750968376 1.1389502071069668e-07 6.943495262094187 5.778446754188237 GASNK(ub)YLVEFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GASNKYLVEFR 11 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 2947120000.0 295160000.0 1729050000.0 922910000.0 True False 382090438.47342575 1632826847.5428972 754949849.8562849 1.0 4.2734041031399945 1.9758407273224434 28.50933891488496 -6.55382298748773 2.3709329869051037 3.2629811514207105 1.9787182873999147 0.0 1.4314216091109668 0.7817223747974695 8.22772377149943 0.5157175943389791 1.614660438866741 2.7936822760398073e-07 6.55382298748773 -1.2842628640207958 GASNYVAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 GASNYVAKR 9 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 2802450.0 848700.0 1032700.0 921050.0 True False 1112653.918822491 878625.1854330711 825748.5813354636 1.0 0.7896661941054502 0.7421432373233753 20.085573494223006 -13.999999999999998 0.20900609969775533 2.21149352537063 0.7138810595665966 0.9994894754350465 0.0025316504135812225 12.72358214605976 0.14491087947745457 6.326971344777092 0.028347492771345222 1.0000000000000041e-14 13.999999999999998 -1.4976124658040333 GASNYVAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 GASNYVAKR 9 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 3259660.0 903660.0 1155500.0 1200500.0 True False 874973.8079384766 1616897.1758528948 886053.0357719815 1.0 1.8479378024611524 1.012662353699031 19.73888030541282 -10.27334914783641 4.684942852681349 0.9998303891196273 1.4303000780812385 0.26136704766199725 0.34099977402750176 0.000604342838534524 9.373574297257476e-05 0.3303006263052062 0.1100572038218612 5.329062971505918e-11 10.27334914783641 0.4304696889616112 GASNYVAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GASNYVAKR 9 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 2189180.0 848700.0 775570.0 564910.0 True False 1162487.3252551157 741302.7529329796 431489.8926866513 1.0 0.6376867401718085 0.37117814819353656 20.148783555745897 -7.864739831830078 0.195572278391218 1.2432843352925462 2.9644696322325716e-09 0.9998858778188953 0.002753022570720416 0.11989227956418277 0.029723914794809073 0.06492518043808347 0.09517017992097884 1.3654008477797005e-08 7.864739831830078 -1.2432843323280767 down GASNYVAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GASNYVAKR 9 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 2534430.0 903660.0 1134100.0 496670.0 True False 751433.3289257598 1127990.3781987757 600521.4006573842 1.0 1.5011183757464384 0.7991679069065016 19.519285580847097 -6.715116637146011 1.7778303118102243 1.3064690335988653 0.8006178755004439 0.4889978104799937 0.2110085804070958 0.3648677133653847 2.2512106011961834 0.09436041966043905 0.23816689303132138 1.9270073132050687e-07 6.715116637146011 -0.5058511580984214 GASQAGMTGYGMPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GASQAGMTGYGMPR 14 0 P37802;P37802-2;C9J5W6;Q9UI15 P37802 TAGLN2;TAGLN3 Transgelin-2;Transgelin-3 0 33655400.0 2281400.0 18125000.0 13249000.0 False True 2990937.493109027 15420820.65069664 11878120.573382076 1.0 5.155848521149457 3.9713703816106762 21.51216632955612 -10.085724790629241 6.058062160663417 0.999989705425388 4.563609451380157 0.923482002635316 0.483561175558861 6.732025267808513e-05 1.0162286939182227e-05 0.4682074385589069 0.1560686983176132 8.208715601043129e-11 10.085724790629241 3.5636197459547687 GASQAGMTGYGMPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GASQAGMTGYGMPR 14 0 P37802;P37802-2;C9J5W6;Q9UI15 P37802 TAGLN2;TAGLN3 Transgelin-2;Transgelin-3 0 27418600.0 10159000.0 2114600.0 15145000.0 False True 9836508.105755456 2958970.807493323 11178070.159738986 1.0 0.3008151648613998 1.1363860060460447 23.2297148287316 -6.68469406451489 1.8850500184392507 0.5595023025187134 1.1333455014929157 0.3458177436015075 0.29603073727702883 0.4281713727947076 2.9454534886640586 0.12582318492588596 0.3298872574343536 2.0668356099266538e-07 6.68469406451489 0.5738431989742023 GASQAGMTGYGMPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GASQAGMTGYGMPR 14 0 P37802;P37802-2;C9J5W6;Q9UI15 P37802 TAGLN2;TAGLN3 Transgelin-2;Transgelin-3 0 33124400.0 2281400.0 16004000.0 14839000.0 False True 3124895.232516816 15296890.36184925 11334333.818798074 1.0 4.895169029244226 3.6271084229820114 21.57537639107901 -10.183491377282943 16.19759957430609 1.0000126121618869 4.261138726113119 0.8981519843931052 0.5176835747623297 0.0 0.0 0.5012449658917667 0.16708165529725552 6.554032984351432e-11 10.183491377282943 3.261126113951232 GASWIDTADGSANHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GASWIDTADGSANHR 15 0 J3KQJ1;Q8NBJ7;C9J660;C9JL30;A8MXB9;A0A494C1B1;Q8NBJ7-2;H7C3B2;E9PBT8;J3QT17;Q8NBJ7-5 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 9821700.0 3036600.0 3844100.0 2941000.0 False True 3981012.0064762337 3270575.2641844386 2636693.532064056 1.0 0.8215436825771762 0.6623174026540823 21.924703791835476 -6.972473777732395 0.1900230187389698 1.1078823081004303 0.37162884539908936 0.9999957970429345 0.00028271874237330725 0.07550788389218747 0.006062275640989909 0.005620272660966407 0.01735631008604716 1.0654331915188439e-07 6.972473777732395 -0.736253462701341 GASWIDTADGSANHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GASWIDTADGSANHR 15 0 J3KQJ1;Q8NBJ7;C9J660;C9JL30;A8MXB9;A0A494C1B1;Q8NBJ7-2;H7C3B2;E9PBT8;J3QT17;Q8NBJ7-5 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 10318400.0 3036600.0 3828900.0 3452900.0 False True 4159313.081029443 3659726.537520903 2637396.134707718 1.0 0.8798872472988039 0.6340941600998582 21.987913853358368 -6.959594188540256 0.44111554365031064 1.00868699194471 0.49569352376242315 0.9997548505103555 0.0023844254025108644 0.07984640682353257 0.021669334164252107 0.0032451807195519465 0.020361246082408368 1.0975032411092387e-07 6.959594188540256 -0.5129934681822867 GATYGK(ub)PVHHGVNQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GATYGKPVHHGVNQLK 16 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 53704110.0 3704600.0 4516300.0 45483210.0 True False 4856766.475397433 3842485.644399514 40777043.734957926 1.0 0.7911612929845634 8.395924313330529 22.211564689228016 -6.900585388204136 0.9575532992644302 0.6888803801768861 9.203748558172204 0.986855489771788 0.4054836402614559 0.11097587998105667 0.17499687303736078 0.3172410956933452 0.8278637135050442 1.2572296416124015e-07 6.900585388204136 8.514868177995318 up GATYGK(ub)PVHHGVNQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GATYGKPVHHGVNQLK 16 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 107633500.0 12517300.0 16790200.0 78326000.0 True False 12119945.163123623 23494614.419736296 57810070.87036752 1.0 1.9385083103528769 4.7698294086562 23.530879835541494 -6.9513247793935555 0.5441051592201701 0.9594045140932478 5.880606889031788 0.9993011894594169 0.042359134234503173 0.08295809556415842 0.03379421513286407 0.04633194783226324 0.23463278129293452 1.1186010447295366e-07 6.9513247793935555 4.92120237493854 GATYGK(ub)PVHHGVNQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GATYGKPVHHGVNQLK 16 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 97043500.0 7057200.0 6859300.0 83127000.0 True False 10706288.350428812 5635204.323044492 66696912.014141575 1.0 0.5263452784567295 6.229695094235922 23.35195507833161 -6.886747055413943 1.0414616735662223 0.6692293303229047 6.690029014586799 0.9787321685110334 0.3768649492471154 0.12182096999419872 0.23759716263427033 0.27683459450234715 0.6825288163739689 1.2979350025376391e-07 6.886747055413943 6.020799684263895 up GATYGK(ub)PVHHGVNQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GATYGKPVHHGVNQLK 16 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 20159700.0 3704600.0 3098100.0 13357000.0 True False 5074290.7330506705 2961215.6979533327 10202351.69605 1.0 0.5835723362608839 2.0105966001511173 22.274774750750908 -6.828613391267919 1.3342064167328056 0.777271242891994 2.0478901057057852 0.903051591077173 0.18656292637725866 0.18252919581926869 0.635966917339586 0.1098081836711029 0.2527028307749284 1.4838384095978935e-07 6.828613391267919 1.2706188628137913 up GATYGK(ub)PVHHGVNQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GATYGKPVHHGVNQLK 16 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 69832380.0 12517300.0 23027040.0 34288040.0 True False 10408689.56041256 22902988.765010413 41457510.63401542 1.0 2.2003719711381833 3.9829711889660975 23.31128511097577 -6.965423259401826 0.35071191493559056 0.8291381839954999 5.4144220873900055 0.9999216068179817 0.010850573298033277 0.0778176266278579 0.014355131434936714 0.02442500725301957 0.15314726262960254 1.0828710434391727e-07 6.965423259401826 4.585283903394505 GATYGK(ub)PVHHGVNQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GATYGKPVHHGVNQLK 16 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 51775200.0 7057200.0 21406000.0 23312000.0 True False 9135684.51820931 20214737.282613706 19069455.20131943 1.0 2.2127227841900132 2.0873592080932806 23.12308140042406 -10.056033859606995 5.074683623766265 0.9999813626889735 2.1500409961466223 0.9911666779912515 0.051179465645222674 1.0791799944689823e-05 2.007519508141144e-06 0.049555105500093566 0.01651810150683164 8.789539868403244e-11 10.056033859606995 1.1500596334576487 GATYGKPVHHGVNQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GATYGKPVHHGVNQLK 16 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 31087580.0 1047600.0 16850400.0 13189580.0 False True 1373413.7449728306 14336386.002344748 11824848.784985187 1.0 10.438504824071318 8.609822661429028 20.389334876456193 -9.429474611030635 8.926586712366154 1.0000487677829275 9.524163742750337 0.9666345884969235 0.7465563672320269 0.0 0.0 0.7228500186880522 0.24095003136116913 3.719849668650867e-10 9.429474611030635 8.52411497496741 GATYGKPVHHGVNQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GATYGKPVHHGVNQLK 16 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 24860620.0 5629700.0 3336120.0 15894800.0 False True 5450988.255041987 4668250.113635965 11731475.046221143 1.0 0.8564043610473725 2.152173972374626 22.3780863811215 -6.879399650502645 1.0831028095805855 0.9116814343996084 2.242967986603631 0.9731996551540644 0.09494354358783702 0.1281650328880217 0.27548914022005744 0.06755980179332044 0.16313595940722395 1.3200802985230165e-07 6.879399650502645 1.3312865522040225 up GATYGKPVHHGVNQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GATYGKPVHHGVNQLK 16 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 53441080.0 1719100.0 50807000.0 914980.0 False True 2608000.383044575 41740093.89309719 734133.8019500202 1.0 16.004634878300855 0.2814929808764038 21.314512650785982 -6.613308282845038 2.141073203875583 9.999999999999998 0.33876290393561065 0.254965060590156 6.256610218184142 0.5012520167902643 4.358137257355511 2.480278400765776 7.15022267597327 2.436080958535265e-07 6.613308282845038 -9.661237096064388 GATYGKPVHHGVNQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GATYGKPVHHGVNQLK 16 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 39316800.0 1047600.0 19416200.0 18853000.0 False True 1434926.0303255087 18558328.08321278 14400309.689723043 1.0 12.93329948095156 10.035576319189342 20.452544937979084 -9.816677705143432 10.258535033599253 1.0000002183520165 11.48443790007045 0.9458135999709398 1.1829905270269716 0.0 0.0 1.145425771951338 0.3818085508247154 1.525184190390913e-10 9.816677705143432 10.484437681718433 GATYGKPVHHGVNQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GATYGKPVHHGVNQLK 16 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 7409540.0 5629700.0 1084700.0 695140.0 False True 4681344.98799698 1078856.505803907 840490.5600357872 1.0 0.23045866274972407 0.17954040178427658 22.158491656555775 -13.669936710253824 0.3888448129780108 9.999999980332086 0.1756834861179573 0.9998143915398077 0.005113600408811821 19.313695389143135 0.20379251642972032 144.52877582512528 0.013450919546892764 2.1382736774766147e-14 13.669936710253824 -9.824316494214129 GATYGKPVHHGVNQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GATYGKPVHHGVNQLK 16 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 17105000.0 1719100.0 1734700.0 13651200.0 False True 2225408.8385271253 1638162.4200761472 11166821.673140518 1.0 0.7361175132028127 5.017874234979321 21.08563897287843 -6.892232835003166 1.0091133099061755 0.7820985420338572 5.4026217695013345 0.9822882585151296 0.260741824731483 0.11734894977035974 0.2114307266258163 0.19628371451105409 0.49342469918089754 1.281643280752381e-07 6.892232835003166 4.620523227467477 up GAVDGGLSIPHSTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAVDGGLSIPHSTK 14 0 P46777;A0A2R8Y6J3;Q5T7N0 P46777 RPL5 60S ribosomal protein L5 0 38194000.0 3085200.0 15463600.0 19645200.0 False True 4044727.0771193015 13156491.156640708 17612503.154064883 1.0 3.252751274879813 4.354435495462082 21.94761092766041 -8.920007035153464 0.2825412962860741 6.370769629070466e-14 4.945289967159288 0.9988371430642111 0.04760658227780974 0.40979491579354377 0.09423339731152357 0.8265611888660295 0.39850019489252186 1.2022449592460966e-09 8.920007035153464 4.945289967159224 GAVDGGLSIPHSTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAVDGGLSIPHSTK 14 0 P46777;A0A2R8Y6J3;Q5T7N0 P46777 RPL5 60S ribosomal protein L5 0 25586300.0 10605700.0 3478600.0 11502000.0 False True 10269027.858766671 4867623.120659352 8489281.147396363 1.0 0.4740101193224304 0.8266879069910267 23.291796276274667 -9.959631665233026 5.547257864949105 1.000000592165813 0.6503490131561881 0.567201733505767 0.14398010390220467 1.0545653469555253e-06 1.977266821286325e-07 0.1394083729579153 0.04646937871625852 1.097408538047399e-10 9.959631665233026 -0.34965157900962496 GAVDGGLSIPHSTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAVDGGLSIPHSTK 14 0 P46777;A0A2R8Y6J3;Q5T7N0 P46777 RPL5 60S ribosomal protein L5 0 30472700.0 3085200.0 15481500.0 11906000.0 False True 4225881.814395058 14797476.13952568 9094048.01176696 1.0 3.5016303790417203 2.1519882503076553 22.0108209891833 -9.986562036382422 5.989878060359729 0.9999984464779358 2.8268093146749522 0.709538751126155 0.5509890917946315 1.1431893462822838e-05 1.93238155461153e-06 0.5334933469944925 0.17783096470507542 1.0314257358874303e-10 9.986562036382422 1.8268108681970165 GAVDGGLSIPHSTK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAVDGGLSIPHSTKR 15 1 P46777;A0A2R8Y6J3;Q5T7N0 P46777 RPL5 60S ribosomal protein L5 1 6247400.0 1357800.0 3018000.0 1871600.0 True False 1129070.8607389901 3001741.4349739016 2262942.906699338 1.0 2.658594371135596 2.004252332947655 20.106704602138954 -10.380952022932801 5.633714290165612 0.9995667119263595 2.3314233520416314 0.8466324502674814 0.26713401846888774 0.0014542193762161534 0.0001597931249120812 0.258727302749099 0.08621713372795253 4.159565592093798e-11 10.380952022932801 1.331856640115272 GAVEALAAALAHISGATSVDQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GAVEALAAALAHISGATSVDQR 22 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 20657000.0 5825100.0 6750000.0 8081900.0 False True 8837102.571853273 5545409.76200929 6484508.922577397 1.0 0.6275144728626064 0.7337822402594902 23.075141998849137 -10.302821386845041 8.221551123011558 1.0000005920788473 0.6806483565610492 0.9233206175568771 0.04338363437118926 4.708459414422103e-07 3.9970431692397846e-08 0.042006101591499034 0.014002007784797314 4.979418323999405e-11 10.302821386845041 -0.3193522355177981 GAVEALAAALAHISGATSVDQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAVEALAAALAHISGATSVDQR 22 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 12074400.0 5825100.0 2481100.0 3768200.0 False True 7540706.779887361 2343024.6039378126 3082426.2649970753 1.0 0.3107168429075041 0.4087715322943665 22.846268320941586 -10.792160116140561 7.225707384095952 1.0201633805260928 0.35974418760093546 0.9827130775034619 0.040030659314151666 0.01205517980133438 0.00034675409479882385 0.03593467621621683 0.012919839738451018 1.613763483140332e-11 10.792160116140561 -0.6604191929251573 GAVHQLCQSLAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAVHQLCQSLAGK 13 0 P09417;P09417-2 P09417 QDPR Dihydropteridine reductase 0 4534840.0 722640.0 2113200.0 1699000.0 False True 947388.0380557138 1797918.797189084 1523203.7779588026 1.0 1.8977638781241954 1.6077929177624115 19.853595930664067 -9.976134353662726 4.972638137290627 0.9999938996663975 1.752778397956528 0.8998593063496344 0.11838014889767641 61526743.774334066 3.5385845688190782 4297.524489947597 0.043322698471911544 1.0564906219315787e-10 9.976134353662726 0.7527844982901304 GAVIVVSHDAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAVIVVSHDAR 11 0 Q8NE71-2;Q8NE71;H0YGW7;A0A0G2JIC2 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 4850600.0 1387400.0 1445000.0 2018200.0 False True 1818894.8356007119 1229411.6325658844 1809376.0239414095 1.0 0.6759113328065811 0.9947667058738123 20.79463070134969 -10.834591687712193 9.865719082741414 1.0038434280431474 0.8353390193401967 0.26230630201326277 0.1301721609599144 0.011176396978535837 0.00018738274458326962 0.12800822263788064 0.04201288429479832 1.4635525215397013e-11 10.834591687712193 -0.1685044087029507 GAVIVVSHDAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAVIVVSHDAR 11 0 Q8NE71-2;Q8NE71;H0YGW7;A0A0G2JIC2 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 3960400.0 1387400.0 1317700.0 1255300.0 False True 1900359.2730752302 1259479.6569488086 958823.9937150225 1.0 0.6627587082050401 0.5045488015344692 20.85784076287258 -13.999999999977012 0.10096717918402986 2.66086073286868 0.17257455902179164 0.999788862983863 0.0030023270698336757 12.073150378500364 0.09482373366648227 4.167955055320758 0.2959176450058266 1.0000000000529315e-14 13.999999999977012 -2.4882861738468884 GAVIVVSHDAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAVIVVSHDAR 11 0 Q8NE71-2;Q8NE71;H0YGW7;A0A0G2JIC2 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 3587740.0 944940.0 1379800.0 1263000.0 False True 1223243.457552102 1303012.9170583196 1033146.9594743663 1.0 1.0652114335978944 0.8445963500527132 20.22228013594358 -6.827524010902425 1.338844850666879 1.0349098827734808 0.8389508542316483 0.9008422395062775 0.029140405613666702 0.18389171458807482 0.6455157833706053 0.017093002296651883 0.039343876944561706 1.487565128575525e-07 6.827524010902425 -0.19595902854183256 GAVLVCDMSSNFLSKPVDVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAVLVCDMSSNFLSKPVDVSK 21 1 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 6100250.0 735650.0 2767200.0 2597400.0 False True 964444.2740447327 2354344.546461117 2328645.964020122 1.0 2.4411410900780757 2.414495089751671 19.87933835565374 -10.077996378038682 4.784900589844748 0.9999446678933552 2.4278180899341932 0.9997388642905821 0.010878184147421577 3777829.851061375 0.20784340395407236 2303.0686564190737 0.0037238917663849603 8.356099870843094e-11 10.077996378038682 1.427873422040838 GAVSAEQVIAGFNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAVSAEQVIAGFNR 14 0 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 0 17339100.0 3387600.0 6024300.0 7927200.0 False True 4441176.405565071 5125497.922537483 7106969.387071817 1.0 1.1540856418391565 1.60024478608108 22.082510446276448 -6.952244768684841 0.5336316985079229 0.9931418428265758 1.7815687135033516 0.9993658705647079 0.006409687781266002 0.08259669535907799 0.032327434844511095 0.007113261331928792 0.03691304136568552 1.116233960194572e-07 6.952244768684841 0.7884268706767757 GAVSAEQVIAGFNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAVSAEQVIAGFNR 14 0 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 0 13688600.0 5621000.0 1436000.0 6631600.0 False True 5442564.431779845 2009402.2886410744 4894585.016264445 1.0 0.369201378105496 0.8993159525469876 22.37585515117891 -10.257410550838706 7.969674139572698 1.0000004415481973 0.634258665326267 0.38825538788850533 0.21641836876571716 1.6980156595394042e-06 1.582857143850322e-07 0.209546437418079 0.06984872817024983 5.5282725890178815e-11 10.257410550838706 -0.3657417762219304 GAVSAEQVIAGFNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAVSAEQVIAGFNR 14 0 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 0 14615800.0 3387600.0 5482900.0 5745300.0 False True 4640087.266447785 5240647.348474327 4388378.468167708 1.0 1.1294286179419852 0.9457534344019413 22.14572050779934 -6.717326893296422 1.768702042955283 1.0789645308143134 0.946076954889588 0.5000089399588118 0.05448245101131401 0.3605216697518885 2.202605124888917 0.024471318157031397 0.0616315353215732 1.917225102797529e-07 6.717326893296422 -0.13288757592472544 GAVVGIDLGTTNSCVAVMEGK ddPTM_RPMI8226_Bortezomib_8h_R1 2 GAVVGIDLGTTNSCVAVMEGK 21 0 P38646;A0A3B3ITI4 P38646 HSPA9 Stress-70 protein, mitochondrial 0 118450400.0 18908400.0 54491000.0 45051000.0 False True 28685425.18920367 44766655.30987382 36146650.10344524 1.0 1.5606063014440743 1.2601050835059524 24.773814566681438 -10.10040846401821 4.48431389103686 0.9999662309038813 1.4103556924900569 0.713169384537977 0.12267910859304898 85398714.65351616 2.1931973240271714 33455.55689436275 0.04199632193111656 7.935815018382255e-11 10.10040846401821 0.4103894615861756 GAVVGIDLGTTNSCVAVMEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GAVVGIDLGTTNSCVAVMEGK 21 0 P38646;A0A3B3ITI4 P38646 HSPA9 Stress-70 protein, mitochondrial 0 48390000.0 13556000.0 18911000.0 15923000.0 False True 17548509.22870905 17858586.22589496 13025177.383776966 1.0 1.0176697059074757 0.7422383983744902 24.06484514091233 -6.891594450791228 1.0129199466170857 1.0142385550806878 0.7177968015105926 0.9818987678128732 0.016936216967038273 0.11785833178289892 0.21437558125638487 0.012712721450398394 0.03187993738533664 1.2835285970539663e-07 6.891594450791228 -0.2964417535700953 GAVWGATLNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAVWGATLNK 10 0 Q9Y3F4;Q9Y3F4-2 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 0 29500600.0 9019200.0 7295400.0 13186000.0 False True 11824258.542057041 6206954.757246475 11821639.209043406 1.0 0.5249339512637774 0.9997784780327393 23.49524638424681 -10.944450011115947 10.410623462756947 1.0627503918684282 0.7623562146485201 0.2503498858065979 0.19385446628955075 0.10964937476982725 0.0005850768430627251 0.07289484095992403 0.0625662599606131 1.1364490995891739e-11 10.944450011115947 -0.30039417721990813 GAVWGATLNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAVWGATLNK 10 0 Q9Y3F4;Q9Y3F4-2 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 0 17149000.0 4537700.0 1814300.0 10797000.0 False True 4393653.197311403 2538759.4514495106 7968941.796943007 1.0 0.5778242700181815 1.8137393733805438 22.06698956783714 -6.814513069999151 1.3954551603452074 0.771112104387637 1.8376713942026388 0.8712888744363061 0.1840210797079911 0.20071130251851715 0.769411190552894 0.10366535090895161 0.23934990410217538 1.5328050762292615e-07 6.814513069999151 1.0665592898150018 GAVWGATLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAVWGATLNK 10 0 Q9Y3F4;Q9Y3F4-2 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 0 26310800.0 9019200.0 7787000.0 9504600.0 False True 12353841.974715376 7442944.591834542 7259809.233381499 1.0 0.6024801520909873 0.5876559897916906 23.5584564457697 GAVWGATLNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAVWGATLNK 10 0 Q9Y3F4;Q9Y3F4-2 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 0 10766300.0 4537700.0 3993200.0 2235400.0 False True 3773298.604194518 3971687.839011861 2702811.804678191 1.0 1.052577136248058 0.7162994738008966 21.847394843271417 -6.866938325256671 1.150081973504815 1.0292539101574392 0.697711100024768 0.9615354874311399 0.028967133186777377 0.13982900289542868 0.34757699969514216 0.01958031378354547 0.046129179216052404 1.3585063562034508e-07 6.866938325256671 -0.3315428101326712 GAVYSFDPVGSYQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAVYSFDPVGSYQR 14 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 27355900.0 4422900.0 10896000.0 12037000.0 False True 5798464.731424528 9270359.272275338 10791526.70705714 1.0 1.5987609999652197 1.861100689044969 22.467239535502507 -10.638682141654584 0.16993786821352463 2.1042699301524756e-22 2.1544342001601495 0.9995572846317381 0.00758257692090922 2.516780778040826 0.09098152060015866 1.2365319287479506 0.20333279157127757 2.2978298050066435e-11 10.638682141654584 2.1544342001601495 GAVYSFDPVGSYQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAVYSFDPVGSYQR 14 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 21673600.0 6486400.0 2989200.0 12198000.0 False True 6280492.782475858 4182803.1484720707 9002977.867843917 1.0 0.6659991967737205 1.433482718579738 22.58244633018353 -6.788426180682643 1.502559632370784 0.8129396204665432 1.4412996122160506 0.7961755076806448 0.1418516412658478 0.2377214000717617 1.0602863084380458 0.07431460199127989 0.17419440439755468 1.627697960513761e-07 6.788426180682643 0.6283599917495074 GAVYSFDPVGSYQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAVYSFDPVGSYQR 14 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 21128200.0 4422900.0 8519100.0 8186200.0 False True 6058165.654378288 8142697.993103586 6252788.160081186 1.0 1.3440863881328151 1.0321256493807234 22.5304495970254 -10.601525280003353 6.952322335422677 0.999680788897054 1.188106018756769 0.3264993181615513 0.12735743828738522 0.0006311886159044134 3.617666112997319e-05 0.12351935242791176 0.04110443645855682 2.503079941463866e-11 10.601525280003353 0.18842522985971488 GAYGGGYGGYDDYNGYNDGYGFGSDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAYGGGYGGYDDYNGYNDGYGFGSDR 26 0 P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 7506700.0 2314700.0 3511200.0 1680800.0 False True 3034594.115586687 2987342.6465504044 1506886.9393720727 1.0 0.9844290645679489 0.4965695186819875 21.53307213470495 -6.913697249814238 0.8701701789966642 1.0133968068623003 0.4282676135534144 0.9922437515609757 0.020585005918661435 0.1020239098342055 0.12587828801811934 0.017167553675764544 0.04869734497175 1.2198396626637053e-07 6.913697249814238 -0.5851291933088858 down GAYGGGYGGYDDYNGYNDGYGFGSDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GAYGGGYGGYDDYNGYNDGYGFGSDR 26 0 P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 21013200.0 7600800.0 1550400.0 11862000.0 False True 7359516.764467564 2169482.8052291907 8754986.347627863 1.0 0.29478604026064004 1.1896142950441742 22.811179609465974 -6.696567296081823 1.8428786048042654 0.5606286691436422 1.1868080332562387 0.40139223412557856 0.2978704997760347 0.40271393706105396 2.6564743277644127 0.12906003744288788 0.33335074317469277 2.0110955448361211e-07 6.696567296081823 0.6261793641125966 GAYGGGYGGYDDYNGYNDGYGFGSDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GAYGGGYGGYDDYNGYNDGYGFGSDR 26 0 P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 14240300.0 7600800.0 3033300.0 3606200.0 False True 6320401.9725327045 3016959.010837088 4360239.74681511 1.0 0.47733657193770784 0.6898674745315098 22.59158488490025 -10.228335959633556 5.515389833229121 1.0000230930134095 0.583602023234585 0.8365515125300226 0.08676537765474858 2.4639298433840156e-05 3.4474352030872665e-06 0.08401486660155082 0.028003405223673897 5.911041934586175e-11 10.228335959633556 -0.41642106977882454 GAYPIIFTAWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GAYPIIFTAWK 11 0 Q6NXE6-2;Q6NXE6;B4E1N1;F5GWV0;F5H4P3;F5H6J3;F5H2X2;F5H2K4 Q6NXE6-2 ARMC6 Armadillo repeat-containing protein 6 0 7818000.0 2050000.0 3580800.0 2187200.0 False True 2687569.8522282373 3046558.5978490775 1960889.5251038787 1.0 1.1335737358875366 0.7296143478756932 21.357870821385767 -6.817593646581567 1.3822727488732116 1.07217482030896 0.7212436317767823 0.8787576829656034 0.0585109086369338 0.19662506516252096 0.7388491049982406 0.033269254496623914 0.07673312820813445 1.5219709160894766e-07 6.817593646581567 -0.35093118853217775 GAYPIIFTAWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GAYPIIFTAWK 11 0 Q6NXE6-2;Q6NXE6;B4E1N1;F5GWV0;F5H4P3;F5H6J3;F5H2X2;F5H2K4 Q6NXE6-2 ARMC6 Armadillo repeat-containing protein 6 0 11626100.0 2050000.0 3641900.0 5934200.0 False True 2807940.399166945 3480988.8158472055 4532664.178685329 1.0 1.2396946946879426 1.6142309074758396 21.421080882908658 -6.9645694691667375 0.3653686698430433 0.9696423611594364 1.8972259426706448 0.9999039896841863 0.002476705753820356 0.07810739424136091 0.015377124348816176 0.004974225043316558 0.03189038297253716 1.0850019802799152e-07 6.9645694691667375 0.9275835815112085 GCAFVTFSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCAFVTFSTR 10 0 Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3;V9GYD9 Q5VZZ6 CELF2 CUGBP Elav-like family member 2 0 20265200.0 6604400.0 6648300.0 7012500.0 False True 8658432.35710057 5656399.554870427 6286913.768649855 1.0 0.6532821787574226 0.7261030067982351 23.04567441236358 -10.262241323463817 7.012236676813563 1.0000020818700728 0.6896925927778308 0.9603346913320843 0.02972897855782468 9.675890823372678e-07 1.0181665006674788e-07 0.028785152914295113 0.00959498657118436 5.467120881661515e-11 10.262241323463817 -0.310309489092242 GCAFVTFSTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GCAFVTFSTR 10 0 Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3;V9GYD9 Q5VZZ6 CELF2 CUGBP Elav-like family member 2 0 38562400.0 9714400.0 12156000.0 16692000.0 False True 14737455.0177699 9986666.824738491 13392818.883636517 1.0 0.6776384940749216 0.9087606284455445 23.812984073973702 -9.948785644797518 5.953239612755106 1.000000114135439 0.7931995612601737 0.516318705826748 0.09435521624537735 1.4292576122115953e-07 2.515425537846093e-08 0.09135909565640334 0.030453015095481234 1.1251601834804793e-10 9.948785644797518 -0.20680055287526544 GCAFVTFTTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCAFVTFTTR 10 0 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4 G5EA30 CELF1 CUGBP Elav-like family member 1 0 33922000.0 13309000.0 8720000.0 11893000.0 False True 17448227.884539355 7419009.990293777 10662426.445711603 1.0 0.4252013464856029 0.6110893619838287 24.05657718190645 -10.210796282773112 5.4761100465436945 1.000022969399738 0.518145354234675 0.8995900834400832 0.07588846454502465 2.128236343912533e-05 3.067140105550006e-06 0.07348218683137306 0.024492896612655413 6.15465505260339e-11 10.210796282773112 -0.481877615165063 GCAFVTFTTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GCAFVTFTTR 10 0 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4 G5EA30 CELF1 CUGBP Elav-like family member 1 0 11174900.0 6817700.0 2201200.0 2156000.0 False True 6601275.8453202965 3080150.639106358 1591278.9213864156 1.0 0.4665992925125079 0.24105626831432705 22.654313454072685 -10.98100034552419 0.16936043435325737 1.9919101099474403 7.668165993706948e-11 0.9995452333478766 0.006786143072851022 3.1157903639722537 0.09627517292000859 1.3826892273566236 0.17563040748984765 1.0447193880429255e-11 10.98100034552419 -1.9919101098707588 GCAFVTFTTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GCAFVTFTTR 10 0 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4 G5EA30 CELF1 CUGBP Elav-like family member 1 0 47496000.0 12080000.0 15755000.0 19661000.0 False True 18326243.1662954 12943397.155623145 15774994.73227757 1.0 0.70627662408343 0.8607871558361757 24.127407731548324 -10.180937852759739 4.69751578435721 1.0000272729048536 0.7835318899615314 0.7235308650356009 0.06307866048367329 2.0316250079203642e-05 3.5422878282395056e-06 0.0610843195289457 0.020358550124008026 6.592682293226493e-11 10.180937852759739 -0.21649538294332216 GCAFVTFTTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCAFVTFTTR 10 0 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4 G5EA30 CELF1 CUGBP Elav-like family member 1 0 32991500.0 13309000.0 7858500.0 11824000.0 False True 18229696.96220143 7511285.485415652 9031414.722923946 1.0 0.41203567459130075 0.4954231955501089 24.119787243429343 -10.703904075244719 6.82167191768849 1.0052184140803075 0.45372943507107744 0.982823940772533 0.03404281287745297 0.002709406870674994 0.00011760222853584557 0.033054351157368815 0.010987270611035892 1.9774063513337783e-11 10.703904075244719 -0.5514889790092301 GCAFVTFTTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GCAFVTFTTR 10 0 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4 G5EA30 CELF1 CUGBP Elav-like family member 1 0 12399700.0 6817700.0 1091900.0 4490100.0 False True 5669219.62532052 1086017.7179748188 5428959.150123262 1.0 0.19156388175972608 0.9576201856558565 22.43471872950696 -10.814255737623075 11.169986190850883 1.0035813335574553 0.5745920346478227 0.2913715651094193 0.31274117646466076 0.02789054246407612 0.0004637875014635985 0.30279100979720996 0.10093678067674548 1.533713577881181e-11 10.814255737623075 -0.42898929890963255 GCAFVTFTTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GCAFVTFTTR 10 0 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4 G5EA30 CELF1 CUGBP Elav-like family member 1 0 58750000.0 12080000.0 27666000.0 19004000.0 False True 15637798.132399302 26126362.779631454 15545466.997506592 1.0 1.6707187647793798 0.9940956435099765 23.898534053640773 -6.648166306512103 2.0149012543839047 1.435853540527035 0.9969264800223028 0.18673400609951796 0.28639825998918195 0.5130264708040702 3.9900672585974246 0.11535550705312635 0.3172328180765433 2.2481935292236809e-07 6.648166306512103 -0.4389270605047322 GCALQCAILSPAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCALQCAILSPAFK 14 0 P34932;A0A087WYC1;A0A087WTS8;Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;O95757;E9PDE8;D6RJ96 P34932;Q92598-2;O95757 HSPA4;HSPH1;HSPA4L Heat shock 70 kDa protein 4;Heat shock protein 105 kDa;Heat shock 70 kDa protein 4L 0 35360900.0 8335900.0 14041000.0 12984000.0 False True 10928445.62497043 11946137.531389324 11640540.231322577 1.0 1.0931232072101422 1.0651597336701828 23.381584882365345 -10.042920623353663 4.388690374361694 0.9999951784263642 1.0791414704492523 0.9143823657490545 0.01141604030349578 5.573973671458268e-07 1.2153963019980856e-07 0.011054230385922705 0.0036845111596420306 9.058981581176033e-11 10.042920623353663 0.07914629202288814 GCALQCAILSPAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCALQCAILSPAFK 14 0 P34932;A0A087WYC1;A0A087WTS8;Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;O95757;E9PDE8;D6RJ96 P34932;Q92598-2;O95757 HSPA4;HSPH1;HSPA4L Heat shock 70 kDa protein 4;Heat shock protein 105 kDa;Heat shock 70 kDa protein 4L 0 43581900.0 8335900.0 15998000.0 19248000.0 False True 11417907.499227198 15291155.461688569 14702018.825003404 1.0 1.339225726143212 1.2876281250306578 23.444794943888237 -10.068670769669835 4.355389203267138 0.9999732685524645 1.3134269256221802 0.9800791049309456 0.02106463257639675 14732875.676614728 13519125.841658346 4787.907507412566 0.007708865949956474 8.537470780720475e-11 10.068670769669835 0.31345365706971573 GCALQCAILSPAFK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCALQCAILSPAFK 14 0 P34932;A0A087WYC1;A0A087WTS8;Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;O95757;E9PDE8;D6RJ96 P34932;Q92598-2;O95757 HSPA4;HSPH1;HSPA4L Heat shock 70 kDa protein 4;Heat shock protein 105 kDa;Heat shock 70 kDa protein 4L 1 6739600.0 2197500.0 2645100.0 1897000.0 True False 2880943.780620271 2250461.390519042 1700716.6373089156 1.0 0.7811542195504123 0.5903331570540918 21.458110077023726 -6.972731410977388 0.18145698593282072 1.144696803025334 0.22162297622884766 0.9999965926749824 0.00030890475656953264 0.07542608354288652 0.00573196975899802 0.00725439914557525 0.021320308508003354 1.0648013400427877e-07 6.972731410977388 -0.9230738267964863 GCALQCAILSPAFK(ub)VR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCALQCAILSPAFKVR 16 1 P34932;A0A087WYC1;A0A087WTS8;Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;O95757;E9PDE8;D6RJ96 P34932;Q92598-2;O95757 HSPA4;HSPH1;HSPA4L Heat shock 70 kDa protein 4;Heat shock protein 105 kDa;Heat shock 70 kDa protein 4L 1 64084500.0 21715000.0 33955000.0 8414500.0 True False 28468575.288359135 28889046.355553333 7543848.257583476 1.0 1.0147696561185529 0.2649886122214262 24.762866959334215 -6.902407500413923 0.9459195750152748 1.0291475356009652 0.18232167780483083 0.9877265465098154 0.03877727870682703 0.10965489788020524 0.16759271118689484 0.0306009942423058 0.08062496084761293 1.25196589855982e-07 6.902407500413923 -0.8468258577961343 down GCALQCAILSPAFK(ub)VR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GCALQCAILSPAFKVR 16 1 P34932;A0A087WYC1;A0A087WTS8;Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;O95757;E9PDE8;D6RJ96 P34932;Q92598-2;O95757 HSPA4;HSPH1;HSPA4L Heat shock 70 kDa protein 4;Heat shock protein 105 kDa;Heat shock 70 kDa protein 4L 1 165748000.0 34693000.0 32817000.0 98238000.0 True False 52631817.398037 26960549.949608684 78821216.24075492 1.0 0.5122481282703003 1.4975963236202954 25.649431876748213 -6.772107775964511 1.5663636425062892 0.7209930073264704 1.503588498147535 0.7385670962350268 0.20568444463585817 0.26303386830065234 1.2739054630914006 0.1034859638159462 0.24586850639441632 1.6900214782423672e-07 6.772107775964511 0.7825954908210645 GCALQCAILSPAFK(ub)VR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCALQCAILSPAFKVR 16 1 P34932;A0A087WYC1;A0A087WTS8;Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;O95757;E9PDE8;D6RJ96 P34932;Q92598-2;O95757 HSPA4;HSPH1;HSPA4L Heat shock 70 kDa protein 4;Heat shock protein 105 kDa;Heat shock 70 kDa protein 4L 1 74869000.0 21715000.0 31427000.0 21727000.0 True False 29743622.32580988 30038451.22480854 16595530.081610998 1.0 1.0099123400562688 0.557952555335209 24.826077020857106 -6.901885971721569 0.949259674326696 1.0178308600154327 0.5086506045847713 0.9874816950754604 0.023580749110527308 0.11003061166680819 0.1696903235788317 0.018562710243921515 0.04877088690301889 1.2534702426534315e-07 6.901885971721569 -0.5091802554306614 GCALQCAILSPAFK(ub)VR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GCALQCAILSPAFKVR 16 1 P34932;A0A087WYC1;A0A087WTS8;Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;O95757;E9PDE8;D6RJ96 P34932;Q92598-2;O95757 HSPA4;HSPH1;HSPA4L Heat shock 70 kDa protein 4;Heat shock protein 105 kDa;Heat shock 70 kDa protein 4L 1 48951800.0 26111000.0 3793800.0 19047000.0 True False 21712453.413430378 3773362.0463896645 23029639.636622347 1.0 0.17378791675636376 1.060665010909233 24.372019417682147 -12.04224901430483 14.739929468597632 0.9465069451818211 0.6555038182833832 0.0 0.4142798655544012 0.0 0.0 0.0 0.12036441652094636 9.073001563047232e-13 12.04224901430483 -0.2910031268984379 GCALQCAILSPAFK(ub)VR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GCALQCAILSPAFKVR 16 1 P34932;A0A087WYC1;A0A087WTS8;Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;O95757;E9PDE8;D6RJ96 P34932;Q92598-2;O95757 HSPA4;HSPH1;HSPA4L Heat shock 70 kDa protein 4;Heat shock protein 105 kDa;Heat shock 70 kDa protein 4L 1 128005000.0 34693000.0 41528000.0 51784000.0 True False 44910772.401269 39216930.29395415 42359843.348709844 1.0 0.8732187891038373 0.9432000627874512 25.420558198840663 -10.134878354725496 4.252245245243273 1.000014004855754 0.9082094259475806 0.6964069139512117 0.0285697355366353 39911361.52579995 0.4925072268056678 7516.156685918628 0.009780180354517184 7.330298250111762e-11 10.134878354725496 -0.0918045789081734 GCAVVEFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCAVVEFK 8 0 P52272-2;P52272;M0R019;M0R2T0;M0R0N3;M0QYL3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 82205000.0 30391000.0 21473000.0 30341000.0 False True 39842895.30686263 18269312.101098448 27201604.371423215 1.0 0.45853374762028654 0.6827215783873505 25.247819153311305 -10.267993992721387 5.627842524825747 1.0000326001444704 0.5706276630038118 0.8302447057253348 0.09152429865348587 3.7439715530524105e-05 4.869849912558044e-06 0.08862473269564439 0.02953934037151767 5.395180852234388e-11 10.267993992721387 -0.4294049371406585 GCAVVEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GCAVVEFK 8 0 P52272-2;P52272;M0R019;M0R2T0;M0R0N3;M0QYL3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 35134800.0 11149000.0 4159800.0 19826000.0 False True 10795081.09765405 5820829.8330704225 14632975.83274909 1.0 0.5392113111901851 1.3555225477582635 23.36387074580668 -6.753542918255317 1.6365538892748976 0.7302095140606214 1.3576113908795375 0.6641306964135157 0.1936714610895442 0.2939124703368416 1.5497835214272664 0.09343965386377949 0.22602486116890252 1.7638314488629035e-07 6.753542918255317 0.6274018768189161 GCAVVEFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GCAVVEFK 8 0 P52272-2;P52272;M0R019;M0R2T0;M0R0N3;M0QYL3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 83255000.0 14872000.0 52503000.0 15880000.0 False True 22561911.288836516 43133429.44218867 12741311.03954875 1.0 1.9117808278738693 0.5647265817348136 24.427385952255364 -6.724393762105895 1.7433004233178893 1.552105050817884 0.5662644931469782 0.5331854838804557 0.3834910272802258 0.34688671480773065 2.0625014042032688 0.17450300791567327 0.43585418860612574 1.8862803383328825e-07 6.724393762105895 -0.9858405576709057 GCAVVEFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCAVVEFK 8 0 P52272-2;P52272;M0R019;M0R2T0;M0R0N3;M0QYL3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 76207000.0 30391000.0 19975000.0 25841000.0 False True 41627373.98589398 19092438.451508258 19737888.01210062 1.0 0.4586510419316385 0.4741564533662171 25.311029214834196 -9.862402779560083 5.870830112681992 1.0000001118337145 0.466403747648213 0.9993671107402726 0.006330057713642332 9.265054360581527e-09 1.78900659442696e-09 0.006129053395190649 0.0020430173417517127 1.3727682322254157e-10 9.862402779560083 -0.5335963641855015 GCAVVEFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GCAVVEFK 8 0 P52272-2;P52272;M0R019;M0R2T0;M0R0N3;M0QYL3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 23950100.0 11149000.0 5363200.0 7437900.0 False True 9270887.484444683 5334307.377088153 8993130.501036035 1.0 0.5753826034496062 0.9700398711693258 23.144276021240955 -10.500339604735105 8.985587951761124 1.0000073592835559 0.772711237309466 0.3066323788832924 0.16111815486571462 2.3754305308075045e-05 1.3209005480002393e-06 0.15600702936565178 0.052000660880548354 3.159805824274641e-11 10.500339604735105 -0.22729612197408988 GCAVVEFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GCAVVEFK 8 0 P52272-2;P52272;M0R019;M0R2T0;M0R0N3;M0QYL3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 48789000.0 14872000.0 22385000.0 11532000.0 False True 19252097.17094721 21139255.07200353 9433294.328312255 1.0 1.0980234976116876 0.48998788259534504 24.198512274347813 -6.865584358113109 1.1571042303612797 1.054209358798311 0.4572295200817242 0.9600791874356278 0.053256711659531795 0.14116421507283297 0.3560141468802247 0.035805476808827286 0.08418489445239426 1.3627482779098952e-07 6.865584358113109 -0.5969798387165868 down GCAYIVMVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCAYIVMVHR 10 0 O95104-2;O95104-3;O95104 O95104-2 SCAF4 Splicing factor, arginine/serine-rich 15 0 16928800.0 7605200.0 3709100.0 5614500.0 False True 9970490.848861558 3155716.737958564 5033565.398086931 1.0 0.3165056551171588 0.5048462983807531 23.24923309980392 -10.348231719138589 4.968995795614861 1.0003401890244012 0.41067597674891665 0.9288482111164508 0.07688974563774331 0.0002899366214879221 3.803005596014018e-05 0.07449000539198701 0.02481605869568484 4.4850602433151594e-11 10.348231719138589 -0.5896642122754846 GCAYIVMVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCAYIVMVHR 10 0 O95104-2;O95104-3;O95104 O95104-2 SCAF4 Splicing factor, arginine/serine-rich 15 0 19590700.0 7605200.0 7605400.0 4380100.0 False True 10417047.962802172 7269368.280305437 3345610.590991137 1.0 0.6978338111011237 0.32116686060560024 23.31244316132681 -7.100666937303096 0.32024408054087344 1.0561988571915892 1.1757533778235467e-14 0.9999392746605186 0.0021639185912191825 0.07641146831459891 0.013812080857988188 0.006832686566796794 0.03378072700277417 7.931093369844316e-08 7.100666937303096 -1.0561988571915775 down GCAYVCMVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCAYVCMVHR 10 0 A0A0A0MT33;Q9UPN6;Q9UPN6-2 A0A0A0MT33 SCAF8 Protein SCAF8 0 3750400.0 1343100.0 1103900.0 1303400.0 False True 1760817.1065988997 939202.422968497 1168536.671095645 1.0 0.5333901059052125 0.6636331886579226 20.747813635730296 -10.429068896448545 8.982474150009054 1.0000029874391747 0.5985116472815761 0.9268469050155832 0.05317151587853735 3.181094656883163e-06 2.0224461597081983e-07 0.051483481488878546 0.017161032957514862 3.723326347440267e-11 10.429068896448545 -0.4014913401575986 GCAYVCMVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCAYVCMVHR 10 0 A0A0A0MT33;Q9UPN6;Q9UPN6-2 A0A0A0MT33 SCAF8 Protein SCAF8 0 3156580.0 1343100.0 726280.0 1087200.0 False True 1839680.3659127424 694190.548113214 830425.75158685 1.0 0.37734302163343303 0.45139675727029954 20.811023697253187 -10.488369033924808 6.172931170738574 1.0004067810001214 0.4143698894533951 0.9881496508250279 0.030232310976213716 0.00016936056094531997 1.403706913819484e-05 0.029291656872027897 0.009757436410686595 3.248111776319889e-11 10.488369033924808 -0.5860368915467262 GCAYVCMVHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GCAYVCMVHR 10 0 A0A0A0MT33;Q9UPN6;Q9UPN6-2 A0A0A0MT33 SCAF8 Protein SCAF8 0 3898110.0 715710.0 1915700.0 1266700.0 False True 926500.7037532715 1809089.6109643583 1036173.5974395713 1.0 1.9526046808552902 1.1183732438000455 19.821432546534975 -10.211993493630898 4.370100302201017 0.9998549073241587 1.5354889620878076 0.3545772887964399 0.340573559188634 239697355.04912895 162.43376497035354 464959.5724802317 0.11658738785117216 6.13771200289822e-11 10.211993493630898 0.5356340547636489 GCCFVTFYTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCCFVTFYTR 10 0 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4;E9PQK4;E9PSH0;E9PKU1;F5H4Y5;F5H0D8;Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3;V9GYD9 G5EA30;Q5VZZ6 CELF1;CELF2 CUGBP Elav-like family member 1;CUGBP Elav-like family member 2 0 90215000.0 27431000.0 32975000.0 29809000.0 False True 35962306.64218187 28055258.535543263 26724650.628118847 1.0 0.7801295621743 0.7431294909423928 25.09998222328725 -13.999999999999998 0.2507454667366932 2.5348597260701187 0.7283574853267625 0.9995440923582879 0.0024208743722975326 14.02766678275902 0.15845188859067402 10.849366311278127 0.0170048509273951 1.0000000000000041e-14 13.999999999999998 -1.8065022407433562 GCCFVTFYTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GCCFVTFYTR 10 0 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4;E9PQK4;E9PSH0;E9PKU1;F5H4Y5;F5H0D8;Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3;V9GYD9 G5EA30;Q5VZZ6 CELF1;CELF2 CUGBP Elav-like family member 1;CUGBP Elav-like family member 2 0 87661000.0 24825000.0 23825000.0 39011000.0 False True 37661339.95060291 19573242.604425363 31300458.750871286 1.0 0.5197171059260737 0.8311031628700775 25.16658099463898 -10.127413235425747 5.263081560290016 1.0000082954441876 0.6754101343978359 0.59163776944383 0.12712282542251505 1.2374187453624287e-05 2.0514858375511855e-06 0.12308928983612585 0.04102871548189801 7.457388429518753e-11 10.127413235425747 -0.32459816104635164 GCCFVTFYTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCCFVTFYTR 10 0 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4;E9PQK4;E9PSH0;E9PKU1;F5H4Y5;F5H0D8;Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3;V9GYD9 G5EA30;Q5VZZ6 CELF1;CELF2 CUGBP Elav-like family member 1;CUGBP Elav-like family member 2 0 92622000.0 27431000.0 31108000.0 34083000.0 False True 37572981.99490172 29733545.699600462 26033297.361418914 1.0 0.7913544286592693 0.6928728032539812 25.16319228481014 -13.999999999937469 0.09994149618610622 2.030581406992354 0.48292706161708265 0.9997940089460179 0.0018377364189966637 12.080892065948909 0.09413572523420002 2.568229033479175 0.1872502076103505 1.0000000001439837e-14 13.999999999937469 -1.5476543453752711 GCCFVTFYTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GCCFVTFYTR 10 0 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4;E9PQK4;E9PSH0;E9PKU1;F5H4Y5;F5H0D8;Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3;V9GYD9 G5EA30;Q5VZZ6 CELF1;CELF2 CUGBP Elav-like family member 1;CUGBP Elav-like family member 2 0 110238000.0 24825000.0 47509000.0 37904000.0 False True 32136451.87390832 44865082.38623259 31005860.92788309 1.0 1.3960807671695297 0.964819048771742 24.93770731673143 -6.665155081672576 1.9541877400491774 1.2538509862414413 0.966578185652927 0.2579834764352721 0.16843432891456475 0.4722964848500079 3.4722718002756543 0.06949991070883335 0.18689188243547333 2.1619463791485286e-07 6.665155081672576 -0.28727280058851434 GCEVVVSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCEVVVSGK 9 0 P23396;P23396-2;E9PL09;H0YEU2;E9PSF4;E9PJN9 P23396;E9PSF4 RPS3 40S ribosomal protein S3 0 23384600.0 4147700.0 10706000.0 8530900.0 False True 5437674.866383933 9108706.531661147 7648204.302171121 1.0 1.67511054917457 1.4065210756628403 22.374558460539973 -10.031917575911645 4.451307011633268 0.9999749984903343 1.5408158123358604 0.8438913355932833 0.10965119360053327 14386182.538278243 8105541.20162787 3433.1492875333743 0.037536520331749326 9.291427106273937e-11 10.031917575911645 0.5408408138455261 GCEVVVSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCEVVVSGK 9 0 P23396;P23396-2;E9PL09;H0YEU2;E9PSF4;E9PJN9 P23396;E9PSF4 RPS3 40S ribosomal protein S3 0 20531300.0 4147700.0 6742600.0 9641000.0 False True 5681216.777377922 6444689.637203485 7363994.3626276795 1.0 1.1343854476501656 1.2962002069610197 22.437768522062864 -6.968651092352922 0.28859011193540224 0.9678445573281266 1.4677307080366966 0.9999698644627459 0.00066474128407054 0.07674284799383699 0.010588877430486764 0.00284859957196059 0.01469819073600326 1.0748525908965882e-07 6.968651092352922 0.49988615070857 GCEVVVSGK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCEVVVSGKLR 11 1 P23396;P23396-2;E9PL09;H0YEU2;E9PSF4;E9PJN9 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 243809000.0 46817000.0 45722000.0 151270000.0 True False 61377540.37647291 38900455.8229601 135618031.48430145 1.0 0.6337897475909825 2.2095709709522056 25.87120749708396 -6.845524343397657 1.2566130671727689 0.8050937193805212 2.2672871022716783 0.9335121539288995 0.17361758378737818 0.16245674106155375 0.495930900224418 0.1082289986880262 0.249817888220196 1.4271698311368464e-07 6.845524343397657 1.462193382891157 up GCEVVVSGK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GCEVVVSGKLR 11 1 P23396;P23396-2;E9PL09;H0YEU2;E9PSF4;E9PJN9 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 124829000.0 40152000.0 28552000.0 56125000.0 True False 38877396.73809362 39952962.49671298 41424178.7860912 1.0 1.0276655807451602 1.0655080396754586 25.2124282823635 -6.966745069931947 0.32673115516543966 0.9952102750796115 1.0991961257245026 0.9999446737086829 0.0001996379774561236 0.07737384514896208 0.012798886012836677 0.000558797294584099 0.003309545009769053 1.0795802479071291e-07 6.966745069931947 0.10398585064489119 GCEVVVSGK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GCEVVVSGKLR 11 1 P23396;P23396-2;E9PL09;H0YEU2;E9PSF4;E9PJN9 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 619874000.0 58062000.0 122638000.0 439174000.0 True False 88084298.90078184 100752290.72493252 352371066.40319735 1.0 1.1438166844969715 4.00038452710066 26.392381544688458 -6.917356139505639 0.844099532620175 0.9307655591676209 4.434142891661367 0.9934143800304603 0.11213112989767524 0.09975302666288131 0.11385885381424712 0.09528300231298346 0.2785880058356195 1.209605799753984e-07 6.917356139505639 3.5033773324937467 up GCEVVVSGK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCEVVVSGKLR 11 1 P23396;P23396-2;E9PL09;H0YEU2;E9PSF4;E9PJN9 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 350798200.0 46817000.0 28999600.0 274981600.0 True False 64126510.081853144 27718301.783146877 210036609.50382137 1.0 0.43224403991058213 3.275347578337319 25.934417558606853 -6.854786795259966 1.211767000105428 0.6952926661718438 3.399944607913017 0.9469852349768793 0.28286009136111323 0.15227023365990988 0.42786499170013353 0.18240646283832115 0.42360106850432333 1.397054037375944e-07 6.854786795259966 2.704651941741173 up GCEVVVSGK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GCEVVVSGKLR 11 1 P23396;P23396-2;E9PL09;H0YEU2;E9PSF4;E9PJN9 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 245289550.0 40152000.0 27655150.0 177482400.0 True False 33388167.035198066 27506166.217832495 214593149.25410095 1.0 0.8238297774428671 6.427221626987644 24.992833557797777 -6.89964241700954 0.9635439827830273 0.7647401891688951 7.011101510347542 0.9863870404357027 0.30346303254963247 0.11166834691257271 0.17891601795557588 0.23637281126193002 0.6138935569707679 1.2599623940963964e-07 6.89964241700954 6.246361321178647 up GCEVVVSGK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GCEVVVSGKLR 11 1 P23396;P23396-2;E9PL09;H0YEU2;E9PSF4;E9PJN9 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 455471000.0 58062000.0 101069000.0 296340000.0 True False 75162403.57312657 95444421.30320857 242409160.70517296 1.0 1.2698425910548397 3.225138489209298 26.163507866780908 -6.931986597923824 0.7303073300795363 0.9723478472720998 3.647633987537851 0.9969143796300715 0.05507491729080994 0.09161944535248456 0.07272403619182537 0.05078227279032734 0.17502808646762663 1.1695354816505888e-07 6.931986597923824 2.6752861402657513 up GCFAVPMVHSTFLIDLR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GCFAVPMVHSTFLIDLR 17 0 Q8NBJ5 Q8NBJ5 COLGALT1 Procollagen galactosyltransferase 1 0 91250700.0 32790900.0 25004500.0 33455300.0 False True 49746192.63590032 20542251.613949824 26842845.291021105 1.0 0.41294118254037204 0.5395959744595497 25.568082776289923 -9.848674386516612 6.619312920831633 1.000000012534993 0.47626857850037185 0.9579811443441205 0.05170660228018444 9.582184360026074e-09 1.6905581880791117e-09 0.050064703872018834 0.01668823412665878 1.4168556732701568e-10 9.848674386516612 -0.5237314340346212 GCFAVPMVHSTFLIDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GCFAVPMVHSTFLIDLR 17 0 Q8NBJ5 Q8NBJ5 COLGALT1 Procollagen galactosyltransferase 1 0 64018100.0 32790900.0 19585200.0 11642000.0 False True 42448466.45527253 18495266.403225537 9523275.457007585 1.0 0.43571106208780924 0.22434910497985014 25.339209098382373 -12.370654122416015 0.15948866169221337 2.6534562120643805 6.668637151544706e-14 0.9995474163350121 0.0069651579446689555 6.358822381731367 0.11108170589490399 3.5884293178733935 0.1859871886207771 4.259375000678854e-13 12.370654122416015 -2.653456212064314 GCGITFTLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCGITFTLGK 10 0 Q7L5Y1;J3QL81;A0A3F2YNX7;Q7L5Y1-4;Q7L5Y1-5;X6RM24;J3QL99;J3QSB6;Q7L5Y1-3 Q7L5Y1 ENOSF1 Mitochondrial enolase superfamily member 1 0 17839200.0 4658900.0 4697700.0 8482600.0 False True 6107863.016851782 3996821.4714911818 7604901.922844815 1.0 0.6543731351642675 1.2451002751474054 22.542236276003027 -6.748141809222734 1.6569455635581576 0.7963129980930747 1.2460941940405925 0.6408517406078011 0.14522262187323964 0.30329379298575054 1.637759031204247 0.06925619946845099 0.1684499332239643 1.78590433221802e-07 6.748141809222734 0.44978119594751786 GCGITFTLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCGITFTLGK 10 0 Q7L5Y1;J3QL81;A0A3F2YNX7;Q7L5Y1-4;Q7L5Y1-5;X6RM24;J3QL99;J3QSB6;Q7L5Y1-3 Q7L5Y1 ENOSF1 Mitochondrial enolase superfamily member 1 0 14944800.0 4658900.0 3220000.0 7065900.0 False True 6381421.232038486 3077729.7528839335 5397079.94677844 1.0 0.4822953447159891 0.8457488936292007 22.60544633752592 -10.25177137003679 5.490841650637387 1.000026176149408 0.6640221191725819 0.5325712408482036 0.14837929000690198 4.755043730336974e-05 6.4795866050571165e-06 0.14367880762683255 0.04788920992655906 5.6005235783505804e-11 10.25177137003679 -0.3360040569768261 GCGTVLLSGPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCGTVLLSGPR 11 0 J3QQ67;Q07020;G3V203;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 93809000.0 29304000.0 25871000.0 38634000.0 False True 38417827.78033968 22011147.644368134 34636524.28349639 1.0 0.5729409733996553 0.901574250411462 25.19527261270152 -9.880658922227534 6.094126244301938 1.0000000396391473 0.7372576119054547 0.4601211867826551 0.13416397352997828 7.219271684120374e-08 1.3181913280333277e-08 0.1299037291104715 0.04330123626183047 1.3162581636640578e-10 9.880658922227534 -0.2627424277336926 GCGTVLLSGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GCGTVLLSGPR 11 0 J3QQ67;Q07020;G3V203;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 22462400.0 11939000.0 3570900.0 6952500.0 False True 11560002.9800782 4996778.9919975 5131431.679470807 1.0 0.43224720621687057 0.44389535956988957 23.462638433965655 -9.935311789865654 5.205030808984726 1.000001561705907 0.4380712828941503 0.9996778384717265 0.0047553387129026905 6512305.096261556 1.9901139071360323 125.98354707269323 0.0016278789230477647 1.1606150827605389e-10 9.935311789865654 -0.5619302788117567 GCGTVLLSGPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GCGTVLLSGPR 11 0 J3QQ67;Q07020;G3V203;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 87135400.0 10565000.0 67306000.0 9264400.0 False True 16027877.40495952 55294718.435821734 7433287.279269227 1.0 3.4499089953552953 0.46377240675481696 23.934080044158186 -6.688692426302909 1.8712600482504687 2.5378203612648207 0.47430313095526716 0.36426239157145435 1.0364153624055732 0.41946278919389984 2.846759826002227 0.44327069069831027 1.1561295181592515 2.0478944720514733e-07 6.688692426302909 -2.0635172303095537 GCGTVLLSGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCGTVLLSGPR 11 0 J3QQ67;Q07020;G3V203;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 79109000.0 29304000.0 19507000.0 30298000.0 False True 40138480.71082352 18645116.238977306 23142236.40689695 1.0 0.46451973041295425 0.5765598497268618 25.25848267422441 -10.167455854218828 5.918133600174743 1.0000056708098952 0.5205397900700299 0.9606566404058829 0.04574018717329915 3.422431201781789e-06 4.814057185922924e-07 0.04428826951893767 0.014762581931212212 6.800551687019368e-11 10.167455854218828 -0.4794658807398653 GCGTVLLSGPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GCGTVLLSGPR 11 0 J3QQ67;Q07020;G3V203;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 19928800.0 11939000.0 3145000.0 4844800.0 False True 9927807.487378705 3128057.2607663777 5857825.2801757725 1.0 0.3150803704385988 0.5900421908485705 23.24304370939993 -10.38323297936285 5.9207202054922785 1.000122076072893 0.45256128064384726 0.8408971645768778 0.11225269312520435 0.00018092526865126838 1.884708577003578e-05 0.10871213491350995 0.03622940092007039 4.13777642264256e-11 10.38323297936285 -0.5475607954290458 GCGTVLLSGPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GCGTVLLSGPR 11 0 J3QQ67;Q07020;G3V203;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 37999300.0 10565000.0 18744000.0 8690300.0 False True 13676600.76728466 17700879.922699753 7108754.5700079845 1.0 1.2942455675858753 0.5197749565822378 23.705206366250636 -6.803755821370403 1.4405958139777302 1.1615830331040269 0.5080741486110727 0.8428988038622582 0.12651833275228314 0.21544084626818263 0.8822774123314615 0.06907927428701136 0.16029487077555912 1.5712459766263434e-07 6.803755821370403 -0.6535088844929542 GCGVVK(ub)FESPEVAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GCGVVKFESPEVAER 15 1 P52272-2;P52272;A0A087X0X3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 20226900.0 9086100.0 3251400.0 7889400.0 True False 7555494.732479411 3233884.062847633 9539037.063535903 1.0 0.4280175127309501 1.2625297748577176 22.849094795227323 -6.722253546650051 1.751506338089608 0.652847243618281 1.2613697740736975 0.5230038928847224 0.24062802273794479 0.35095348081216204 2.1053627626334133 0.10904089898069534 0.27297955930683276 1.8955989233075865e-07 6.722253546650051 0.6085225304554166 GCGVVK(ub)FESPEVAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GCGVVKFESPEVAER 15 1 P52272-2;P52272;A0A087X0X3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 72913200.0 15947200.0 16828800.0 40137200.0 True False 20643964.766307827 15892262.486295871 32832641.44245015 1.0 0.7698260807067926 1.5904232454433833 24.29921673765606 -6.831847227082811 1.3198767726028602 0.8771653560693254 1.6133112922340107 0.9094732008864773 0.10398324049692997 0.1785456937514628 0.6076955002070181 0.061848671536870785 0.14231038535739185 1.472830512796751e-07 6.831847227082811 0.7361459361646853 GCHLLVATPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCHLLVATPGR 11 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 18663300.0 5541300.0 5533100.0 7588900.0 False True 7264697.962025536 4707583.047854871 6803673.4258690635 1.0 0.6480080895947264 0.9365390634866904 22.792471386762998 -9.969681205036702 6.553359799071642 1.0000000367656268 0.7922735765407055 0.4086669365137571 0.11779227683727822 6.332865537007448e-08 9.854674997975795e-09 0.11405190201968625 0.038017293875217795 1.0723061454504803e-10 9.969681205036702 -0.20772646022492125 GCHLLVATPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GCHLLVATPGR 11 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 5953090.0 2621600.0 835790.0 2495700.0 False True 2538378.7429912873 1169525.305587271 1842001.3006048573 1.0 0.4607371176647477 0.7256605444285269 21.27547591425939 -10.108265869733112 5.308321462581647 1.0000075122617826 0.5931988310463359 0.7586787660430513 0.10815453608121027 150693034.29322273 0.2134212595226609 13836.893010681883 0.03702417444245204 7.793528542339906e-11 10.108265869733112 -0.4068086812154468 GCHLLVATPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GCHLLVATPGR 11 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 24615400.0 3331600.0 16110000.0 5173800.0 False True 5054280.772585247 13235044.631995484 4151196.162242905 1.0 2.618581204230529 0.821322824952517 22.2690743796229 -6.669415657359646 1.9393179711542805 2.033647598624283 0.8285897236246116 0.2765027478650506 0.6876300340621068 0.4624687671439808 3.3526563988271048 0.28549937598246666 0.7633996444371298 2.140840650729423e-07 6.669415657359646 -1.2050578749996712 GCHLLVATPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCHLLVATPGR 11 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 17554900.0 5541300.0 5135600.0 6878000.0 False True 7590068.358001858 4908692.210841847 5253558.05685647 1.0 0.6467256919586026 0.6921621531007539 22.85568144828589 -10.385575789525575 5.080123347538999 1.0002499737293085 0.6694439225296487 0.9860276611788236 0.01854935758611366 5.255618383679592e-05 6.356437126866581e-06 0.017973765028461732 0.005986779417807307 4.115515204259204e-11 10.385575789525575 -0.3308060511996598 GCITIIGGGDTATCCAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCITIIGGGDTATCCAK 17 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 587540000.0 186290000.0 182940000.0 218310000.0 False True 244227994.03492603 155646065.0945349 195721375.37739006 1.0 0.6372982168140668 0.8013879659896841 27.86365333428356 -10.04164845647641 4.6190184923680295 1.0000096302875665 0.7193430913892452 0.7959418161817947 0.0669893596280384 21251434.207697596 23100084.701924223 1839.4267473591474 0.02293223971916968 9.085556710580359e-11 10.04164845647641 -0.28066653889832127 GCITIIGGGDTATCCAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GCITIIGGGDTATCCAK 17 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 620970000.0 155180000.0 465790000.0 0.0 False True 235419405.1776261 382666135.26611954 0.0 1.0 1.6254655599753742 0.0 27.8106580030083 -6.817456800641893 1.4834689668418275 1.343085950752987 3.274042679738854e-21 0.8385018358176451 0.2690266170191236 0.2086448692099768 0.9191399068556085 0.144698045706777 0.3187753041793362 1.5224505638078958e-07 6.817456800641893 -1.343085950752987 GCITIIGGGDTATCCAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCITIIGGGDTATCCAK 17 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 367220000.0 186290000.0 180930000.0 0.0 False True 255166447.29795617 172935914.34450024 0.0 1.0 0.6777376734902929 0.0 27.92686339580645 -7.474295379078524 0.7262597738424538 0.9923174160231472 3.155545662899707e-17 0.9871434220461323 0.04725482071773278 0.1178326166966639 0.14139867312097984 0.0415032771610544 0.07498478334906272 3.355093448211119e-08 7.474295379078524 -0.9923174160231472 down GCITIIGGGDTATCCAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GCITIIGGGDTATCCAK 17 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 155180000.0 155180000.0 0.0 0.0 False True 200883569.05510974 0.0 0.0 1.0 0.0 0.0 27.58178432510075 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 GCITIIGGGDTATCCAK(ub)WNTEDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GCITIIGGGDTATCCAKWNTEDK 23 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 21786600.0 2490000.0 3428600.0 15868000.0 True False 3777512.043383745 2816739.5422259294 12731682.844808534 1.0 0.7456599766927033 3.370388419305739 21.84900492429133 -6.883113802652006 1.062308081606601 0.8348221730798969 3.5678543965011262 0.976110427142373 0.18268210039365024 0.12490640268960182 0.2559363732899254 0.1320796648539559 0.3220778696328547 1.3088389095322101e-07 6.883113802652006 2.733032223421229 up GCITIIGGGDTATCCAK(ub)WNTEDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GCITIIGGGDTATCCAKWNTEDK 23 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 28812100.0 2490000.0 5828100.0 20494000.0 True False 3223354.0852379417 5503761.111688363 16764302.286197685 1.0 1.7074640160986492 5.200887598099598 21.620131246383778 -6.940084142975729 0.6587796286185984 0.9608435521898047 6.145291208511699 0.998174909099889 0.07845388202231536 0.08772825119087922 0.054434877666834795 0.07641776333854755 0.30056064096185664 1.147931192458272e-07 6.940084142975729 5.184447656321894 GCK(ub)GLGLGTEGPQGTGGLEPDLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCKGLGLGTEGPQGTGGLEPDLAR 24 1 H0YKX0;Q96EP0-3;Q96EP0 H0YKX0 RNF31 E3 ubiquitin-protein ligase RNF31 1 16818300.0 5150900.0 5111400.0 6556000.0 True False 6752879.781386558 4348799.044081146 5877648.00959265 1.0 0.6439917760816725 0.8703913293101454 22.687071443386895 -10.751722432108306 5.7476717064023335 1.0090833454839496 0.7571915526961255 0.6053064032937081 0.09242723056730644 0.011002169545495995 0.0004752513260390489 0.09152177181516945 0.029830760393604223 1.7712406384893297e-11 10.751722432108306 -0.25189179278782414 GCK(ub)GLGLGTEGPQGTGGLEPDLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GCKGLGLGTEGPQGTGGLEPDLAR 24 1 H0YKX0;Q96EP0-3;Q96EP0 H0YKX0 RNF31 E3 ubiquitin-protein ligase RNF31 1 25900100.0 7033700.0 8770400.0 10096000.0 True False 6810419.043552726 12272466.457031794 7451554.726492234 1.0 1.8020134118839382 1.0941404161534607 22.69931213899413 -10.272476720201446 5.6546559573985 0.999965531489721 1.448076914018687 0.34820981062275524 0.2889879403725266 0.00012559695393189355 1.615876716897907e-05 0.279832841725595 0.0932704566931277 5.3397789600712016e-11 10.272476720201446 0.4481113825289661 GCK(ub)GLGLGTEGPQGTGGLEPDLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GCKGLGLGTEGPQGTGGLEPDLAR 24 1 H0YKX0;Q96EP0-3;Q96EP0 H0YKX0 RNF31 E3 ubiquitin-protein ligase RNF31 1 84676000.0 18190000.0 37550000.0 28936000.0 True False 27595559.867128618 30848909.12051093 23216786.91690066 1.0 1.117893939062916 0.8413232791321664 24.717932819874733 -6.790861997305777 1.4927486199413722 1.0658159121402064 0.8383054497204206 0.8041634566988467 0.05014706965427545 0.23405871768896655 1.0303029519690232 0.026440263024120815 0.06186818937475745 1.6185942852236036e-07 6.790861997305777 -0.22751046241978579 GCK(ub)GLGLGTEGPQGTGGLEPDLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCKGLGLGTEGPQGTGGLEPDLAR 24 1 H0YKX0;Q96EP0-3;Q96EP0 H0YKX0 RNF31 E3 ubiquitin-protein ligase RNF31 1 18989900.0 5150900.0 7280100.0 6558900.0 True False 7055326.927838552 6958441.109928675 5009822.904785684 1.0 0.9862677068120558 0.7100766493212637 22.750281504909786 -6.917235106153628 0.8449761254702051 1.0067221511159234 0.6682522030941891 0.9933778461312213 0.010868021864135442 0.09982612949576566 0.11424480997715124 0.009229317461608454 0.02695601847931578 1.2099429512790424e-07 6.917235106153628 -0.33846994802173436 GCK(ub)GLGLGTEGPQGTGGLEPDLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GCKGLGLGTEGPQGTGGLEPDLAR 24 1 H0YKX0;Q96EP0-3;Q96EP0 H0YKX0 RNF31 E3 ubiquitin-protein ligase RNF31 1 23085500.0 7033700.0 7708100.0 8343700.0 True False 5848833.195742991 7666574.93536194 10088329.093090018 1.0 1.310787071332787 1.7248447263691327 22.479717414428407 -6.967152581325105 0.31895439472680626 0.9425946268113452 2.1063718772787365 0.9999508894001611 0.0020807485940652973 0.0772378910229144 0.01232308502245988 0.006303109402226871 0.036455323476354995 1.078567720857499e-07 6.967152581325105 1.1637772504673913 GCK(ub)GLGLGTEGPQGTGGLEPDLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GCKGLGLGTEGPQGTGGLEPDLAR 24 1 H0YKX0;Q96EP0-3;Q96EP0 H0YKX0 RNF31 E3 ubiquitin-protein ligase RNF31 1 76497000.0 18190000.0 33200000.0 25107000.0 True False 23547313.578505263 31352390.814854473 20537783.619574726 1.0 1.331463596062777 0.8721922163691007 24.489059141967182 -6.713063951230699 1.7841457471023066 1.2031368811190934 0.8731656878703197 0.4796578001339462 0.1396124008808456 0.36897454147565123 2.2913159911443883 0.06222625646633577 0.15750750771786085 1.93613684070491e-07 6.713063951230699 -0.3299711932487738 GCLGNSK(ub)TEDQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCLGNSKTEDQR 12 1 P63092;P63092-4;A0A0A0MR13;Q5JWD1;P63092-2;P63092-3 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 138106000.0 41382000.0 61811000.0 34913000.0 True False 54252202.74385804 52589039.73739087 31300537.66914401 1.0 0.9693438621410545 0.5769450102685016 25.69317837915345 -6.922485072931721 0.806092488270471 1.0079074609785108 0.5099055859584514 0.9948435555592053 0.013831109008470479 0.09673179831991328 0.09820232505106018 0.012076450845026614 0.03708005476922056 1.1954046120341422e-07 6.922485072931721 -0.49800187502005944 GCLGNSK(ub)TEDQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GCLGNSKTEDQR 12 1 P63092;P63092-4;A0A0A0MR13;Q5JWD1;P63092-2;P63092-3 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 116917000.0 62813000.0 37165000.0 16939000.0 True False 60819035.69709782 52005178.31291471 12502167.740892624 1.0 0.8550806127857812 0.20556339964280634 25.85801960642629 -6.942272313651107 0.6380816419121589 1.007101943874366 0.01804898989531796 0.9984465459771974 0.013615412622299518 0.0867453211738566 0.050004080549948454 0.013493915382406043 0.055367273736416464 1.1421619457182395e-07 6.942272313651107 -0.989052953979048 down GCLGNSK(ub)TEDQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GCLGNSKTEDQR 12 1 P63092;P63092-4;A0A0A0MR13;Q5JWD1;P63092-2;P63092-3 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 74366000.0 40277000.0 16168000.0 17921000.0 True False 61103153.6431193 13282694.07883941 14378906.49494668 1.0 0.21738148175491342 0.23532183917917726 25.86474350625025 -10.055438103123649 5.969923666886463 1.0000017765649805 0.22635166091807127 0.9995968548855019 0.007324120248935692 1.7318338925375355e-07 2.740978534139045e-08 0.007091565153738127 0.0023638496457875965 8.801605457157478e-11 10.055438103123649 -0.7736501156469092 GCLGNSK(ub)TEDQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCLGNSKTEDQR 12 1 P63092;P63092-4;A0A0A0MR13;Q5JWD1;P63092-2;P63092-3 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 127078000.0 41382000.0 51127000.0 34569000.0 True False 56682043.70650076 48868040.085620165 26404514.170903046 1.0 0.8621432272036369 0.4658356058512188 25.756388440676343 -6.952405779120895 0.5317847938075219 1.0061713751526955 0.3037618791829873 0.9993767607990752 0.0056525280743369 0.08253400196041868 0.03207491153331256 0.0062897649719544585 0.032780197299533395 1.1158202040623388e-07 6.952405779120895 -0.7024094959697083 down GCLGNSK(ub)TEDQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GCLGNSKTEDQR 12 1 P63092;P63092-4;A0A0A0MR13;Q5JWD1;P63092-2;P63092-3 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 121554000.0 62813000.0 41620000.0 17121000.0 True False 52231792.587714024 41395784.79907686 20700921.941440143 1.0 0.7925399981162812 0.3963280009330834 25.638424881860566 -6.960937491070302 0.4220199644893764 1.0171371066142598 0.15673531345885852 0.9998033888879767 0.0035114979494513423 0.07936800532419501 0.01990695343296221 0.0051322746925422 0.032963463685362564 1.0941138330736859e-07 6.960937491070302 -0.8604017931554013 down GCLGNSK(ub)TEDQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GCLGNSKTEDQR 12 1 P63092;P63092-4;A0A0A0MR13;Q5JWD1;P63092-2;P63092-3 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 61400000.0 40277000.0 12722000.0 8401000.0 True False 52139370.47836487 12014009.516463222 6872104.201539312 1.0 0.23042106964924733 0.13180259252249465 25.6358698283427 -13.999999999999998 0.28966914775173186 7.619094807316718 0.10483903286298442 0.9996267220226785 0.007498659919026716 15.946068908740845 0.1706692348158713 62.885112050253255 0.03730140876355081 1.0000000000000041e-14 13.999999999999998 -7.5142557744537335 GCLGNSK(ub)TEDQRNEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCLGNSKTEDQRNEEK 16 2 P63092;P63092-4;A0A0A0MR13;Q5JWD1;P63092-2;P63092-3 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 19524100.0 7483000.0 4844500.0 7196600.0 True False 9810285.465475073 4121719.4837130993 6451964.86666175 1.0 0.420142665391185 0.6576735090296689 23.225863686771053 -10.29015485434561 5.685771710297874 1.0000424394803187 0.5389080872104288 0.834005023951605 0.09697156084786812 5.217296217838671e-05 6.5137161237064595e-06 0.09390092195661826 0.031297436684958414 5.1267854801255e-11 10.29015485434561 -0.46113435226988986 GCLGNSK(ub)TEDQRNEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GCLGNSKTEDQRNEEK 16 2 P63092;P63092-4;A0A0A0MR13;Q5JWD1;P63092-2;P63092-3 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 15623620.0 9300200.0 4680700.0 1642720.0 True False 9004970.241672093 6549727.919528044 1212442.3514563523 1.0 0.7273458705302566 0.13464146120611933 23.102290077852945 -7.2484239026058 0.5713469000551774 1.0036025452381663 8.504201683869077e-28 0.9979099151552404 0.016515216250961976 0.09344020988133193 0.05527774298498257 0.016409761541053166 0.055275741757395684 5.6438582477531724e-08 7.2484239026058 -1.0036025452381663 down GCLGNSK(ub)TEDQRNEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GCLGNSKTEDQRNEEK 16 2 P63092;P63092-4;A0A0A0MR13;Q5JWD1;P63092-2;P63092-3 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 77975700.0 46429000.0 14099100.0 17447600.0 True False 70436187.41456367 11583005.448228914 13999074.212445261 1.0 0.16444679749707697 0.19874832421084102 26.06981348497971 -10.474850374484173 6.049267442365871 1.000544748926474 0.1815975608548507 0.9986842220735961 0.014003539641195065 0.00010294436618788985 8.936799864901964e-06 0.013567107415063685 0.0045196229848586 3.350808631694135e-11 10.474850374484173 -0.8189471880716234 GCLGNSK(ub)TEDQRNEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCLGNSKTEDQRNEEK 16 2 P63092;P63092-4;A0A0A0MR13;Q5JWD1;P63092-2;P63092-3 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 30386800.0 7483000.0 18089800.0 4814000.0 True False 10249667.320471339 17290532.82103101 3677032.3474421445 1.0 1.6869360029371074 0.35874650683521436 23.289073748293944 -6.7661181161979655 1.5891450511611764 1.3959529460693771 0.35231720810008493 0.7155643384519322 0.28924246198283904 0.2727482869871171 1.358702582332113 0.14351372858913214 0.3428765343922519 1.713491221473097e-07 6.7661181161979655 -1.0436357379692922 GCLGNSK(ub)TEDQRNEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GCLGNSKTEDQRNEEK 16 2 P63092;P63092-4;A0A0A0MR13;Q5JWD1;P63092-2;P63092-3 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 16736500.0 9300200.0 5235000.0 2201300.0 True False 7733528.36871759 5206798.015933857 2661581.652338776 1.0 0.6732758668081633 0.34416136146923215 22.88269535328722 -7.249916304413419 0.2676604376329135 1.0988298327654604 4.469440250868653e-15 0.9999382552382442 0.002103879007288498 0.09788055836450667 0.01572922038155547 0.01268242329880016 0.04349309899070254 5.624497079224918e-08 7.249916304413419 -1.098829832765456 down GCLGNSK(ub)TEDQRNEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GCLGNSKTEDQRNEEK 16 2 P63092;P63092-4;A0A0A0MR13;Q5JWD1;P63092-2;P63092-3 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 97377000.0 46429000.0 22905000.0 28043000.0 True False 60103255.75241449 21630316.614886824 22939461.745478716 1.0 0.35988593869173024 0.3816675396084044 25.84093980707216 -10.200887825954714 5.09267094015178 1.000053602882112 0.3707767391497255 0.9991020723159341 0.008892301339388228 5.412373419389248e-06 8.492634996014829e-07 0.008610663769113859 0.002869977916180922 6.296687991884649e-11 10.200887825954714 -0.6292768637323867 GCLGNSK(ub)TEDQRNEEK(ub)AQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GCLGNSKTEDQRNEEKAQR 19 3 P63092;P63092-4;A0A0A0MR13;Q5JWD1;P63092-2;P63092-3 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 2 3948830.0 2079800.0 1085300.0 783730.0 True False 2692342.0989870955 1024902.1009446259 641099.181748887 1.0 0.38067305834953563 0.23811951014326124 21.36043030511009 -13.999999999999849 0.2063794077945133 4.529562824644909 0.15114824616243447 0.9994883008552395 0.007481015768684418 12.664360270250237 0.14401478898511297 18.094344118373208 0.08663566741316771 1.0000000000003477e-14 13.999999999999849 -4.378414578482475 GCLLYGPPGTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCLLYGPPGTGK 12 0 A0A087X2I1;P62333;H0YJC0;H0YJS8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 0 4290100.0 1093400.0 3196700.0 0.0 False True 1433457.9885006608 2719764.8206390017 0.0 1.0 1.8973453302832866 0.0 20.45106819230518 -6.785855610241032 1.5639577361060077 1.5089234478310536 1.8719803233159804e-18 0.7602788381976922 0.37943354631928766 0.24827901004764386 1.2078211445002198 0.19256771054229446 0.44274606169358277 1.6373608038101038e-07 6.785855610241032 -1.5089234478310536 GCLTLYTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCLTLYTGR 9 0 F8WAF5;C9JT95;C9JMP5;H7C0W4;Q96AH0-2;Q96AH0-3;Q96AH0;Q9BQ15 F8WAF5 NABP1;NABP2 SOSS complex subunit B2;SOSS complex subunit B1 0 12873800.0 4883200.0 3340700.0 4649900.0 False True 6401922.488976063 2842280.58194661 4168772.952990365 1.0 0.44397297637404076 0.6511751681106541 22.610073778940126 -10.135129946630835 5.251591067418933 1.000012989835128 0.5475740722420259 0.8640730846402241 0.08458994055796945 1.28655257094139e-05 2.118667549958806e-06 0.08190620755538654 0.027301285919644508 7.3260529518467e-11 10.135129946630835 -0.45243891759310206 GCLTLYTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCLTLYTGR 9 0 F8WAF5;C9JT95;C9JMP5;H7C0W4;Q96AH0-2;Q96AH0-3;Q96AH0;Q9BQ15 F8WAF5 NABP1;NABP2 SOSS complex subunit B2;SOSS complex subunit B1 0 10418000.0 4883200.0 1997600.0 3537200.0 False True 6688651.003518062 1909339.4268201727 2701786.2109207213 1.0 0.2854595681275504 0.4039358922299354 22.673283840463018 -9.972208507987219 5.8640622779496 1.0000006157555754 0.3446977301942599 0.9760711114714739 0.04836775677596939 3.893662310774096e-07 6.818966585427674e-08 0.04683192308255708 0.015610626373788652 1.0660841634648122e-10 9.972208507987219 -0.6553028855613154 GCLYLK(ub)DWHLCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GCLYLKDWHLCR 12 1 A0A087WT84;Q9H9V9-2;Q9H9V9 A0A087WT84 JMJD4 JmjC domain-containing protein 4 1 32093700.0 4400000.0 8880700.0 18813000.0 True False 6675121.683087733 7295869.699774202 15094602.303969193 1.0 1.0929942623007478 2.261322417868918 22.670362705747905 -6.922740011019775 0.8041219715506995 0.9766793669766555 2.4621494158738213 0.9949093898057195 0.04094913442637912 0.09658579146762108 0.09744857107027155 0.03580414713085231 0.11023231110915088 1.194703095554991e-07 6.922740011019775 1.4854700488971657 up GCQLLVYPGAFNLTTGPAHWELLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GCQLLVYPGAFNLTTGPAHWELLQR 25 0 Q9NQR4 Q9NQR4 NIT2 Omega-amidase NIT2 0 79452000.0 26730000.0 24011000.0 28711000.0 False True 40551364.22475803 19726049.45120075 23036258.26552166 1.0 0.4864460130581083 0.5680760365506327 25.273247114466326 -10.742353454087617 6.955437332709763 1.0076309209332204 0.5272610248047006 0.9781267440838438 0.03332531754134805 0.003948122580418729 0.00014624800877476886 0.03230523869228815 0.010755699987059573 1.8098665185109104e-11 10.742353454087617 -0.48036989612851977 GCQLLVYPGAFNLTTGPAHWELLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GCQLLVYPGAFNLTTGPAHWELLQR 25 0 Q9NQR4 Q9NQR4 NIT2 Omega-amidase NIT2 0 62980000.0 26730000.0 16969000.0 19281000.0 False True 34602511.92707235 16024660.233050177 15772055.83976664 1.0 0.4631068480468548 0.4558066730244194 25.044373436558775 GCSMYVALFPCNECAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCSMYVALFPCNECAK 16 0 D6RBJ9;P32321;P32321-2;D6R9S0;D6RBN2 D6RBJ9 DCTD Deoxycytidylate deaminase 0 5724500.0 1732100.0 1802500.0 2189900.0 False True 2270799.873680262 1533574.0260899705 1963310.1550041093 1.0 0.6753453018316946 0.8645896883119836 21.114769135795566 -10.227918230364823 5.359309823282373 1.0000167480073958 0.7699674962424509 0.6633021900059113 0.0772586972605684 1.5461524343790995e-05 2.22749037612399e-06 0.07481085427375074 0.024935137319972916 5.916730247988169e-11 10.227918230364823 -0.23004925176494495 GCSMYVALFPCNECAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCSMYVALFPCNECAK 16 0 D6RBJ9;P32321;P32321-2;D6R9S0;D6RBN2 D6RBJ9 DCTD Deoxycytidylate deaminase 0 6645400.0 1732100.0 1804700.0 3108600.0 False True 2372504.1782424743 1724962.3866551702 2374412.703626637 1.0 0.7270640037114724 1.0008044349939043 21.177979197318457 -11.002323985679983 8.804242641114284 1.142629661520012 0.8639342193525095 0.24779601006233876 0.11175406310189337 0.06945043863989236 1.833225090723541e-05 0.02401914093751174 0.03606846877205381 9.946631172483031e-12 11.002323985679983 -0.2786954421675025 GCTDNLTLTVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCTDNLTLTVAR 12 0 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 0 30767100.0 8739600.0 7588500.0 14439000.0 False True 11457700.2344068 6456325.379741326 12944990.788668124 1.0 0.5634922582765223 1.1298070750529046 23.44981416263696 -6.700862526696839 1.8278956564068831 0.729170924712878 1.1281431546763836 0.4215948049177498 0.18422708460037238 0.393747654271071 2.5583180372140606 0.08038886081790265 0.20651126996283864 1.9913035743892383e-07 6.700862526696839 0.39897222996350556 GCTDNLTLTVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCTDNLTLTVAR 12 0 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 0 16992400.0 8739600.0 8252800.0 0.0 False True 11970866.298809495 7888164.007639918 0.0 1.0 0.6589467972275654 0.0 23.513024224159853 -7.5145419583686435 0.7095270800735051 0.9935459726328547 5.547323509163438e-17 0.9870717304930098 0.04719421544942855 0.11952440178273345 0.1429491941395708 0.04180994075012501 0.07582308537878032 3.058144776570531e-08 7.5145419583686435 -0.9935459726328547 down GCTVWLTGLSGAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCTVWLTGLSGAGK 14 0 O43252;O95340;O95340-2 O43252 PAPSS1;PAPSS2 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase;Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 2;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 0 18980700.0 5214000.0 4716000.0 9050700.0 False True 6835604.492447825 4012391.182824024 8114220.384444809 1.0 0.5869841046621452 1.1870523511723996 22.704637494528516 -6.72149940692754 1.753945323331856 0.7491289863826138 1.1861949787156854 0.519571061175044 0.17376736816130567 0.352413371932468 2.119559719996949 0.07864075957116437 0.19706854559472387 1.8988934352280974e-07 6.72149940692754 0.43706599233307153 GCTVWLTGLSGAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GCTVWLTGLSGAGK 14 0 O43252;O95340;O95340-2 O43252 PAPSS1;PAPSS2 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase;Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 2;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 0 6405400.0 3345300.0 949300.0 2110800.0 False True 3239105.2826246424 1328360.4405341016 1557918.1573573498 1.0 0.41010103859845304 0.4809717565262253 21.6271639310207 -10.438338034796354 6.031229351253666 1.000227175196462 0.44553639756336155 0.9878951416936947 0.028932849437960134 8.841651868147714e-05 8.23386734547604e-06 0.028025307920387477 0.009338037002628788 3.644701497363293e-11 10.438338034796354 -0.5546907776331005 GCTVWLTGLSGAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCTVWLTGLSGAGK 14 0 O43252;O95340;O95340-2 O43252 PAPSS1;PAPSS2 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase;Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 2;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 0 15684100.0 5214000.0 4778100.0 5692000.0 False True 7141756.703051933 4566987.742936253 4347666.830419748 1.0 0.6394768028130406 0.6087671438823772 22.767847556051407 -13.999999999999998 0.3488347709161635 5.40189417799952 0.6044586813656702 0.9997524821934539 0.002794649659215351 20.544561438409467 0.1900455680513887 66.97516117911523 0.009199267771071067 1.0000000000000041e-14 13.999999999999998 -4.797435496633851 GCWDSIHVVEVQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCWDSIHVVEVQEK 14 0 P47756-2;B1AK88;B1AK87;P47756;B1AK85 P47756-2 CAPZB F-actin-capping protein subunit beta 0 21676200.0 2706700.0 10441000.0 8528500.0 False True 3548509.9117200826 8883243.498699239 7646052.631148699 1.0 2.5033728859991347 2.1547220724662988 21.758781905415244 -10.339160584404029 5.905731947884871 0.9998337353025188 2.329047479232719 0.950919885503689 0.14233609859362367 0.0003116323349728904 3.487095580148531e-05 0.13783286184022148 0.04593877828476891 4.57972515827027e-11 10.339160584404029 1.3292137439302 GCWDSIHVVEVQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCWDSIHVVEVQEK 14 0 P47756-2;B1AK88;B1AK87;P47756;B1AK85 P47756-2 CAPZB F-actin-capping protein subunit beta 0 17699200.0 2706700.0 8220400.0 6772100.0 False True 3707440.1358171552 7857195.5467723925 5172669.455777504 1.0 2.1193047652651016 1.3952132108095112 21.821991966938135 -10.115235612211233 4.831911050113341 0.9999598090605021 1.757258988042701 0.5932113615874886 0.295609139264418 0.00012799734641944183 2.3437712296633453e-05 0.2862374521166969 0.09540743944383669 7.669452954882086e-11 10.115235612211233 0.7572991789821989 GCYFVLDWLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GCYFVLDWLQK 11 0 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3;Q9Y4W2-4 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 0 1199120.0 0.0 669310.0 529810.0 False True 0.0 569451.5569499457 474990.34349638235 0.0 GCYFVLDWLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GCYFVLDWLQK 11 0 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3;Q9Y4W2-4 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 0 2179160.0 0.0 730360.0 1448800.0 False True 0.0 698090.2802224566 1106623.2789726167 0.0 GDADQASNILASFGLSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDADQASNILASFGLSAR 18 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 0 10238800.0 3436600.0 3858600.0 2943600.0 False True 4505415.880081739 3282911.9207049976 2639024.5090050222 1.0 0.7286590201847111 0.5857449299346688 22.10322885193107 -13.999999999717904 0.08044522863848806 2.459217384157782 0.16246550834138437 0.9998848331702148 0.001843747596994019 12.254145455732882 0.07993329407374178 3.17553770923738 0.38419706498967043 1.0000000006495503e-14 13.999999999717904 -2.2967518758163976 GDADQASNILASFGLSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDADQASNILASFGLSAR 18 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 0 46068000.0 17034000.0 14519000.0 14515000.0 False True 16493264.993940203 20316512.415584773 10713086.059333857 1.0 1.2318065842663215 0.6495430749017831 23.97537368604954 -6.798684746348189 1.4613920176166433 1.128110789757873 0.6417739141153121 0.828265389866774 0.09918770830477217 0.22263597907477417 0.938856511767854 0.05339965670618414 0.12428238021547428 1.589700290702561e-07 6.798684746348189 -0.4863368756425609 GDADQASNILASFGLSAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDADQASNILASFGLSAR 18 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 0 78974000.0 10170000.0 50612000.0 18192000.0 False True 15428633.526591433 41579893.16663915 14596343.22616315 1.0 2.6949822286578855 0.9460554754253628 23.879106956080747 -6.653310911181814 1.9966135055302896 2.0969877040027334 0.953397344324565 0.2075908895747769 0.7228528821060085 0.5004966213296513 3.828034308540905 0.2932295570999842 0.8008649176740003 2.2217187939185655e-07 6.653310911181814 -1.1435903596781682 GDADQASNILASFGLSAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDADQASNILASFGLSAR 18 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 0 18339500.0 3436600.0 6564900.0 8338000.0 False True 4707203.890622988 6274841.010778801 6368736.126500334 1.0 1.33302936447657 1.3529764748850608 22.166438913453963 -12.032859161578003 0.4375353153707039 2.9698820588939157e-13 1.353300520992196 0.9998156576523254 0.0021981266118410677 6.059135919092103 0.219778361980732 5.595635314261516 0.0046336579084470106 9.271304360350166e-13 12.032859161578003 1.353300520991899 GDADQASNILASFGLSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDADQASNILASFGLSAR 18 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 0 29822100.0 17034000.0 6115000.0 6673100.0 False True 14164525.734149333 6082057.2812675405 8068414.357071684 1.0 0.42938658133849655 0.5696212148931679 23.755778961483816 -10.18964333742909 8.08382194723773 1.0000001408061836 0.4995038981160423 0.9443937580436025 0.05725054941252084 1.4534729723092546e-07 1.450966092887356e-08 0.05543262180279096 0.018477535369659834 6.461846877240435e-11 10.18964333742909 -0.5004962426901414 GDADQASNILASFGLSAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDADQASNILASFGLSAR 18 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 0 47340000.0 10170000.0 19208000.0 17962000.0 False True 13165265.480670623 18139057.914810997 14693100.30568374 1.0 1.3777965922102327 1.116050437969238 23.650233278173197 -10.230422768026767 4.39021892970009 0.9998967359224519 1.2469235150945472 0.5426682259095059 0.10685742002065558 75342504.14990026 14.365096788797047 78648.821110605 0.03658013711140672 5.882707189003485e-11 10.230422768026767 0.24702677917209537 GDAEAVK(ub)GIGSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDAEAVKGIGSGK 13 1 Q99538;Q99538-2;Q99538-3;G3V4E4;G3V2T4 Q99538 LGMN Legumain 1 9553680.0 1113700.0 615480.0 7824500.0 True False 1460071.485086143 523652.78312224883 7014895.797903844 1.0 0.3586487295115922 4.804487910049124 20.47760757449425 -6.870288056879607 1.1324999685365182 0.6365947058532355 5.066367044186898 0.964973444505256 0.3672273400066334 0.1365826711411327 0.3272164959739893 0.2515982959432487 0.5960007149373624 1.348068445254325e-07 6.870288056879607 4.429772338333663 up GDAEAVK(ub)GIGSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDAEAVKGIGSGK 13 1 Q99538;Q99538-2;Q99538-3;G3V4E4;G3V2T4 Q99538 LGMN Legumain 1 23599890.0 982590.0 1776300.0 20841000.0 True False 951398.2182925723 2485585.853282127 15382116.883401802 1.0 2.612560971306932 16.16790591746885 19.859689797968336 -6.929187805691254 0.7534420503332616 0.7875185950387642 18.89393163666688 0.9963758826737065 0.40948883151139526 0.09306227993798766 0.07976627272603075 0.37127372390858093 1.2320544874246657 1.1770968413519905e-07 6.929187805691254 18.106413041628116 GDAEAVK(ub)GIGSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDAEAVKGIGSGK 13 1 Q99538;Q99538-2;Q99538-3;G3V4E4;G3V2T4 Q99538 LGMN Legumain 1 92012400.0 1093400.0 15968000.0 74951000.0 True False 1658767.7382473005 13118385.64144657 60136901.997809626 1.0 7.908512650063845 36.2539616675641 20.661680462648103 -6.9442908547947875 0.6183562096233303 0.6893869083302151 44.970552983993244 0.9986736354445599 0.5555230031604566 0.08586247133191546 0.04609681824989178 0.5602962283438107 2.397407262937627 1.1368656515183962e-07 6.9442908547947875 44.28116607566303 GDAEAVK(ub)GIGSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDAEAVKGIGSGK 13 1 Q99538;Q99538-2;Q99538-3;G3V4E4;G3V2T4 Q99538 LGMN Legumain 1 20366890.0 982590.0 2536300.0 16848000.0 True False 817067.1211176335 2522636.4484838694 20370838.903649546 1.0 3.0874286619601774 24.931659073229 19.640095073402613 -6.92546505055425 0.7831171960375541 0.6061273225979714 28.938812524446185 0.9955694678940727 0.7204086516887758 0.09506192354435654 0.0897226266151825 0.6394105259896303 2.0280391230291444 1.1872302384520365e-07 6.92546505055425 28.332685201848214 GDAEAVK(ub)GIGSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDAEAVKGIGSGK 13 1 Q99538;Q99538-2;Q99538-3;G3V4E4;G3V2T4 Q99538 LGMN Legumain 1 119930400.0 1093400.0 12117000.0 106720000.0 True False 1415427.8541362078 11442678.298300952 87298055.03967093 1.0 8.084254004796357 61.67608951919789 20.432806784740553 -6.931151925964567 0.7372745883948866 0.21886467967303122 73.00809740990823 0.9967598452574344 1.541915335634738 0.09204412125631976 0.07478200395992245 1.41450701634872 4.818789081510094 1.1717853769960707e-07 6.931151925964567 72.7892327302352 GDAEK(ub)PEEELEEDDDEELDETLSER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDAEKPEEELEEDDDEELDETLSER 25 1 Q9NS69 Q9NS69 TOMM22 Mitochondrial import receptor subunit TOM22 homolog 1 12829100.0 3445400.0 3145200.0 6238500.0 True False 3336027.6629166077 4401094.762001318 4604449.699011664 1.0 1.3192620705529605 1.3802192800122364 21.669699821232392 -12.533527715140393 0.2564128700789414 4.121550512990388e-15 1.4046792886626351 0.9994471053349312 0.0039205993033089 6.821826782618502 0.15269346947350854 3.5563527063799274 0.027149508641800987 2.92733405328526e-13 12.533527715140393 1.404679288662631 GDAMIMEETGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDAMIMEETGK 11 0 Q9UQ80;F8VR77;F8W0A3;H0YIN7 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 12144000.0 3926500.0 1112700.0 7104800.0 False True 3801855.4067574367 1557006.912653846 5243839.740568743 1.0 0.409538697838538 1.3792843702704518 21.858272233367245 -6.74191454339328 1.6797756402398913 0.6494545452394752 1.3800825019395788 0.6134522970179065 0.2480786700095356 0.3143717507980706 1.7424518001583336 0.1168017083910803 0.28601089166579446 1.8116965470867365e-07 6.74191454339328 0.7306279567001036 GDANSEVTVYYQSGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDANSEVTVYYQSGTR 16 0 O43847-2;G3V1R5;O43847;H0Y5G9 O43847-2 NRD1 Nardilysin 0 2691000.0 1440500.0 1250500.0 0.0 False True 1888509.4498218452 1063930.274410821 0.0 1.0 0.563370373662249 0.0 20.84881657215283 -7.746136312825333 0.6346095531227025 1.002137851005276 2.335091667311216e-19 0.9877265709936066 0.04534891716237892 0.1188050034805265 0.15324661214899138 0.04304195579815079 0.0779318898770301 1.794170398811043e-08 7.746136312825333 -1.002137851005276 down GDATVSYEDPPTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDATVSYEDPPTAK 14 0 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2;H7BY36 B0QYK0 EWSR1 RNA-binding protein EWS 0 11374200.0 1293200.0 4853600.0 5227400.0 False True 1695397.723366613 4129461.799184619 4686518.792761529 1.0 2.435689126079865 2.764259222582497 20.69319232423168 -10.213115151623546 0.33458573313241957 8.989399273533799e-14 2.841589911897592 0.9989604645927409 0.024699502680567392 1.6367298501364944 0.15447358858300736 1.5989789350517702 0.1025980294452751 6.121880507386528e-11 10.213115151623546 2.8415899118975023 GDATVSYEDPPTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDATVSYEDPPTAK 14 0 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2;H7BY36 B0QYK0 EWSR1 RNA-binding protein EWS 0 10143800.0 2447100.0 1736300.0 5960400.0 False True 2369418.149974815 2429613.6446848838 4399192.431832833 1.0 1.025405180048405 1.8566551589383211 21.1761013941837 -6.913421866557646 0.8721143405422765 0.9769633793588104 1.972327977081143 0.9921498480652329 0.03526130138117896 0.10219870006714064 0.12681757937065652 0.02936641596848932 0.08312098734643085 1.2206134002052801e-07 6.913421866557646 0.9953645977223327 GDATVSYEDPPTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDATVSYEDPPTAK 14 0 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2;H7BY36 B0QYK0 EWSR1 RNA-binding protein EWS 0 10661800.0 1293200.0 4116900.0 5251700.0 False True 1771330.9874159477 3935001.7452322603 4011356.6221566033 1.0 2.2214943300758927 2.2646002642388416 20.756402385754573 -10.83257343914145 0.5980575436150226 5.542945556523964e-19 2.259487175850905 0.9998926916415047 0.006072866495361585 2.5079123965791723 0.29427578142563987 3.572290126657507 0.007511956852101493 1.4703697550430562e-11 10.83257343914145 2.259487175850905 GDATVSYEDPPTAK(ub)AAVEWFDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDATVSYEDPPTAKAAVEWFDGK 23 1 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2;H7BY36 B0QYK0 EWSR1 RNA-binding protein EWS 1 38016000.0 13792000.0 13857000.0 10367000.0 True False 13354180.509359103 19390172.36330035 7651571.696666493 1.0 1.4519926812215096 0.5729720136180568 23.67078811069309 -6.766953795887881 1.5862934636531745 1.2602583366265732 0.5686056576857019 0.7187212445548702 0.19034886966347775 0.27137628891513016 1.3472177038978945 0.09461437966197164 0.2258403625064524 1.710197251416133e-07 6.766953795887881 -0.6916526789408712 GDATVSYEDPPTAK(ub)AAVEWFDGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDATVSYEDPPTAKAAVEWFDGK 23 1 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2;H7BY36 B0QYK0 EWSR1 RNA-binding protein EWS 1 131641000.0 31601000.0 40982000.0 59058000.0 True False 47941027.34255802 33668441.90617253 47385160.41395907 1.0 0.7022887028598261 0.9884051936428676 25.514757489471695 -10.664526132910272 9.080941509564417 1.000138976038695 0.8453469483459257 0.2803456860980641 0.1168065682356963 0.0003289474839442353 1.2152080702589071e-05 0.1131981535676 0.03769915779204097 2.1650795955132022e-11 10.664526132910272 -0.15479202769276923 GDATVSYEDPPTAK(ub)AAVEWFDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDATVSYEDPPTAKAAVEWFDGK 23 1 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2;H7BY36 B0QYK0 EWSR1 RNA-binding protein EWS 1 39223300.0 13792000.0 18967000.0 6464300.0 True False 11468659.089197332 18864821.00634528 7815955.24245381 1.0 1.6449020639313108 0.6815055868053388 23.451193386127365 -6.726326083774661 1.7367892507316516 1.3896807073488449 0.6824683136177321 0.5420951687518656 0.27118828192465994 0.3431606999845596 2.0261774868006763 0.12383011059068708 0.30854318349819104 1.8779062883647645e-07 6.726326083774661 -0.7072123937311128 GDCLQK(ub)GESVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDCLQKGESVK 11 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 3202210.0 1099900.0 1647020.0 455290.0 True False 1064984.276554821 2304683.6750958366 336035.8905927743 1.0 2.1640541797963353 0.3155313162742986 20.022400699959476 -6.73648697990528 1.6994432809720172 1.6954129175524846 0.31523485989992234 0.5890963922787611 0.4891447735738108 0.32422131101139234 1.8371668523333018 0.227823621864273 0.5612539192667599 1.834480163781185e-07 6.73648697990528 -1.3801780576525622 GDCLQK(ub)GESVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDCLQKGESVK 11 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 22862800.0 3481100.0 3602400.0 15779300.0 True False 5281083.202499249 2959523.5743203354 12660514.43868711 1.0 0.5604008611187482 2.3973328866880146 22.332402440308886 -6.843548580572816 1.265883455034424 0.7661479028879359 2.4620930627096196 0.9303732675065318 0.20665240116536585 0.16469617904854494 0.5111357356252025 0.12792887568742278 0.2950528860183678 1.4336773346448314e-07 6.843548580572816 1.6959451598216837 up GDCLQK(ub)GESVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDCLQKGESVK 11 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 20479400.0 3481100.0 2140300.0 14858000.0 True False 4506352.57273967 2021190.4235250924 12153996.455954181 1.0 0.44852025910087523 2.6970806788349164 22.103528762401336 -6.841840400306152 1.2737004975049886 0.706643899476922 2.77382676491696 0.9275857055772878 0.257490221164872 0.1666647578329175 0.5244041409911999 0.15846215175895553 0.36529091463182467 1.4393274222113885e-07 6.841840400306152 2.067182865440038 up GDDLLPAGTEDYIHIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDDLLPAGTEDYIHIR 16 0 P41567;K7EM18;O60739 P41567 EIF1;EIF1B Eukaryotic translation initiation factor 1;Eukaryotic translation initiation factor 1b 0 16749800.0 4377300.0 2829900.0 9542600.0 False True 4238345.007512884 3959893.827733548 7043106.788136369 1.0 0.934301908106642 1.6617587231930784 22.015069599311026 -6.884845138062545 1.0523693527616091 0.9559478024339993 1.718361494534956 0.9773895924695787 0.04940144433706595 0.1234264665187875 0.24706475194713537 0.03598778188004294 0.08820714090119139 1.303631548155758e-07 6.884845138062545 0.7624136921009566 GDDLSTAILK(ub)QK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDDLSTAILKQK 12 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 601400000.0 221820000.0 274690000.0 104890000.0 True False 290808168.107936 233707322.73323342 94036988.97592616 1.0 0.8036477250752148 0.32336433184718355 28.115492550788723 -6.95592821120779 0.48946376045868467 1.0105619025403967 0.09610273295565165 0.999588082406303 0.005768587389458916 0.08118912832771051 0.02676036392165461 0.006907098405305836 0.03961231833115456 1.1068067237904579e-07 6.95592821120779 -0.914459169584745 down GDDLSTAILK(ub)QK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDDLSTAILKQK 12 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 1232410000.0 457720000.0 534880000.0 239810000.0 True False 443189929.1432603 748460373.3623508 176996566.85420987 1.0 1.688802755083391 0.39936955967471016 28.723349857678798 -6.761576660014335 1.6064015001417171 1.3993054228607709 0.39426477073119115 0.6974332398830925 0.2897824096487793 0.28027072272309483 1.4257698752498291 0.14230328391508554 0.3414652006319478 1.7315033653683192e-07 6.761576660014335 -1.0050406521295798 GDDLSTAILK(ub)QK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDDLSTAILKQK 12 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 915960000.0 445480000.0 318650000.0 151830000.0 True False 675825728.9504373 261784417.87618637 121820733.95054697 1.0 0.387354915123962 0.1802546555008131 29.332076034611898 -12.329430436493185 0.17739906422351245 2.720470232247449 1.995100885967442e-20 0.9994738046766908 0.007983743881663547 6.208755471529848 0.11950043684815334 4.0005869477269425 0.15525363540465287 4.683489635797218e-13 12.329430436493185 -2.720470232247449 GDDLSTAILK(ub)QK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDDLSTAILKQK 12 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 580940000.0 221820000.0 238860000.0 120260000.0 True False 303832848.46010387 228306375.39560792 91857064.83244523 1.0 0.7514209755552047 0.30232762947784736 28.178702612311614 -6.961983617830973 0.4065144329139958 1.0229815397642346 0.014195014837832056 0.9998368364879312 0.00368794938686524 0.07900002037371948 0.018568229169104982 0.005778737386537204 0.03753934531326159 1.0914815078153191e-07 6.961983617830973 -1.0087865249264025 down GDDLSTAILK(ub)QK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDDLSTAILKQK 12 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 1060360000.0 457720000.0 492140000.0 110500000.0 True False 380614460.43412125 489488744.1378583 133605039.10572603 1.0 1.2860487317784963 0.3510246009921399 28.503755133113074 -6.824581134296496 1.3518182544166522 1.153505160289053 0.3285136545214315 0.8946317661292873 0.12698196593674002 0.18758595747502826 0.6722705147523866 0.07378935375663277 0.16991115396854575 1.4976794325006054e-07 6.824581134296496 -0.8249915057676214 down GDDLSTAILK(ub)QK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDDLSTAILKQK 12 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 940807000.0 445480000.0 397630000.0 97697000.0 True False 576682641.7236131 375501540.9551386 79917148.4558727 1.0 0.6511407033733909 0.1385808114789323 29.103202356704347 -7.444360012243789 0.49121935599800065 1.0146834530996194 2.524354896707238e-29 0.9977127611709583 0.016919714630859964 0.11322250817845268 0.0618157578596632 0.01941459872316165 0.06540544685400952 3.5945124134009356e-08 7.444360012243789 -1.0146834530996194 down GDDLSTAILK(ub)QK(ub)NRPNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDDLSTAILKQKNRPNR 17 3 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 2 13048400.0 5355900.0 4400800.0 3291700.0 True False 5185879.886171438 6158062.389868821 2429505.0211167266 1.0 1.1874672235062338 0.4684846302736775 22.306157360623054 -6.837455427431948 1.2942502512624672 1.0997823302371736 0.446016073438414 0.9199743035715644 0.08614492122089629 0.1717928504081165 0.5601019951551033 0.0522137622505267 0.1202149373890032 1.4539335982536875e-07 6.837455427431948 -0.6537662567987597 down GDDLSTAILK(ub)QK(ub)NRPNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDDLSTAILKQKNRPNR 17 3 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 2 14318200.0 5355900.0 6693000.0 2269300.0 True False 4453668.1566003505 6656943.480543509 2743800.1379423016 1.0 1.4947102582570948 0.6160764658399573 22.08656263605733 -6.753935499255865 1.6352417052189927 1.2895138782020055 0.6137891325555159 0.6657331186328883 0.20793456788801204 0.29323634876328775 1.5438733558747249 0.1003999831474972 0.24274916780162656 1.762237751799941e-07 6.753935499255865 -0.6757247456464895 GDECILK(ub)DNNER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDECILKDNNER 12 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 7959300.0 2230200.0 2235500.0 3493600.0 True False 2923813.7972875205 1901972.1139107514 3132115.784977559 1.0 0.6505106842560385 1.0712432467085573 21.47942000568851 -6.68616179489269 1.8797581413532984 0.7801151618043036 1.0697380521276825 0.35267725864451405 0.1479255677304803 0.4249592793217491 2.9081384349144397 0.06302136153299094 0.164928365276557 2.0598623757720543e-07 6.68616179489269 0.28962289032337885 GDEEGVPAVVIDMSGLR ddPTM_RPMI8226_Bortezomib_1h_R1 2 GDEEGVPAVVIDMSGLR 17 0 P13796 P13796 LCP1 Plastin-2 0 56457100.0 10802300.0 21114600.0 24540200.0 False True 14161919.909622004 17964383.98406616 22001015.510220457 1.0 1.2684991935211167 1.5535333945274152 23.75551352683092 -6.970367988182145 0.24925077617699531 0.9087056766042809 1.921667117372208 0.9999851086583866 0.0008721479777694183 0.07618354797977611 0.008602337404829033 0.006389732101643882 0.027351366458494796 1.070611765648253e-07 6.970367988182145 1.012961440767927 GDEEGVPAVVIDMSGLR ddPTM_RPMI8226_Bortezomib_2h_R1 2 GDEEGVPAVVIDMSGLR 17 0 P13796 P13796 LCP1 Plastin-2 0 85732200.0 25866700.0 17571400.0 42294100.0 False True 25045575.767215703 24587751.653640456 31216006.4141972 1.0 0.9817203598020481 1.2463680892917823 24.578052441986582 -6.890342231015527 1.0203341256893144 0.9858966466955807 1.2692853292402766 0.9811171980118464 0.016583006066988544 0.1188667750077341 0.22021859700726526 0.012377766195807868 0.03089688140059575 1.287234790266337e-07 6.890342231015527 0.28338868254469585 GDEEGVPAVVIDMSGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GDEEGVPAVVIDMSGLR 17 0 P13796 P13796 LCP1 Plastin-2 0 70497700.0 10802300.0 24315200.0 35380200.0 False True 14796202.231181027 23240874.06438619 27024125.4380915 1.0 1.5707323880319195 1.826423092619115 23.818723588353812 -10.676676994851155 0.16342868468563737 3.482819211897283e-18 2.131732725383047 0.9995932120291124 0.0069675909248177355 2.595614116861703 0.08859275528430069 1.227805191417774 0.20971197922485516 2.1053437003412163e-11 10.676676994851155 2.131732725383047 GDEEGVPAVVIDMSGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GDEEGVPAVVIDMSGLR 17 0 P13796 P13796 LCP1 Plastin-2 0 53383800.0 25866700.0 15830300.0 11686800.0 False True 21509307.139105316 15745019.031831482 14130455.846342081 1.0 0.732009586826998 0.6569461189501542 24.35845771742086 -13.999999999999998 0.1785287184142332 2.384292088433012 0.5964047808016257 0.9994999850358529 0.003292622996551996 12.186051170103376 0.13392963388009466 5.849650379640573 0.05675381729605736 1.0000000000000041e-14 13.999999999999998 -1.7878873076313861 GDFCIQVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDFCIQVGR 9 0 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 0 1410380000.0 382440000.0 458450000.0 569490000.0 False True 501382543.55422854 390051047.0241033 510564637.7338188 1.0 0.7779509917897972 1.0183135497987221 28.901336526379332 -10.097129828502654 12.231317312273532 0.9999959367712461 0.8981331921668201 0.19321332208561148 0.0981276034295899 0.0 0.0 0.09501164346275044 0.03167054782091681 7.995951873505096e-11 10.097129828502654 -0.10186274460442601 GDFCIQVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDFCIQVGR 9 0 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 0 564210000.0 299270000.0 131660000.0 133280000.0 False True 289769837.6621155 184232524.59782988 98369969.68570569 1.0 0.6357891700676355 0.33947622181577586 28.11033219070884 -7.645796756594239 0.23045980889891707 1.1681803852894974 5.400298830081334e-13 0.9998597076109053 0.003199577782756721 0.1306916727575839 0.027704656731200678 0.03903442291111732 0.07681455265338678 2.2604934002622545e-08 7.645796756594239 -1.1681803852889574 down GDFCIQVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDFCIQVGR 9 0 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 0 2257090000.0 593700000.0 1019800000.0 643590000.0 False True 900686305.2839073 837808722.2662325 516384154.4044816 1.0 0.9301892538514227 0.5733229775728754 29.746449484879278 -6.93931337625068 0.6659276807812776 1.0040571292622977 0.47900293850537257 0.9980724715224225 0.008204226865444204 0.08808150822062621 0.056048206274031405 0.007945197027271747 0.030808910236168 1.1499702991198359e-07 6.93931337625068 -0.5250541907569252 GDFCIQVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDFCIQVGR 9 0 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 0 1218340000.0 382440000.0 402830000.0 433070000.0 False True 523838403.05239403 385031638.61932784 330787785.3566198 1.0 0.7350198770761318 0.631469139011434 28.964546587902223 -13.999999999998659 0.1299131963705461 2.2592324651812397 0.48629346796134637 0.999646008592365 0.002919819672846167 11.936907604272337 0.11207857472961512 3.8385172522304574 0.12910552125178282 1.000000000003088e-14 13.999999999998659 -1.7729389972198932 GDFCIQVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDFCIQVGR 9 0 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 0 529234000.0 299270000.0 68424000.0 161540000.0 False True 248856264.9089388 68055386.33089943 195317267.12343 1.0 0.2734726664639212 0.7848597550674494 27.890737466143115 -9.930512799421054 6.343633915136986 1.0000000773450175 0.5291662107672045 0.5305714990277752 0.20877290468779142 2.2825213571771128e-07 3.869897998793295e-08 0.2021435273762953 0.06738116524958103 1.1735110965487985e-10 9.930512799421054 -0.470833866577813 GDFCIQVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDFCIQVGR 9 0 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 0 2137910000.0 593700000.0 979250000.0 564960000.0 False True 768556353.5766127 924753876.6700683 462143076.9791277 1.0 1.2032349643153202 0.6013131956146914 29.517575806971728 -6.815640578109906 1.3907686140215743 1.1100489398593396 0.5893768274753676 0.8740186286330937 0.08873979731053762 0.1992162368116171 0.7583191858768815 0.0501564468234404 0.11575056821272671 1.5288307943983586e-07 6.815640578109906 -0.520672112383972 GDFDENLNYPEQK(ub)VVTVGQFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDFDENLNYPEQKVVTVGQFK 21 1 F8VXU5;Q9UBQ0;Q9UBQ0-2 F8VXU5 VPS29 Vacuolar protein sorting-associated protein 29 1 17381000.0 5363500.0 4806400.0 7211100.0 True False 4459987.893337437 4780506.969204294 8718907.669640739 1.0 1.071865458725945 1.9549173401715951 22.088608363271156 -6.923054427124414 0.8017434130786159 0.9825768670328133 2.107828849072738 0.9949882881380763 0.03073892666782888 0.09640764847697046 0.09654325895520154 0.026922563919858058 0.08315981449181978 1.1938384795670977e-07 6.923054427124414 1.1252519820399245 GDFGTQK(ub)EAAWAISNLTISGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDFGTQKEAAWAISNLTISGR 21 1 O00629;O00505 O00629;O00505 KPNA4;KPNA3 Importin subunit alpha-3;Importin subunit alpha-4 1 11073200.0 1909100.0 2536300.0 6627800.0 True False 1848496.6654885071 3549057.8166297744 4891780.350262004 1.0 1.9199698235278426 2.646356058732321 20.81792101036757 -6.973784734820857 0.14098656753255176 0.040751132178895554 4.544536792151116 0.9999988910877033 0.0007093830408951219 0.07509260595770413 0.004273367221814025 0.04063737466720196 0.09417883916345127 1.0622219344485119e-07 6.973784734820857 4.503785659972221 GDFGTQK(ub)EAAWAISNLTISGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDFGTQKEAAWAISNLTISGR 21 1 O00629;O00505 O00629;O00505 KPNA4;KPNA3 Importin subunit alpha-3;Importin subunit alpha-4 1 9185800.0 1909100.0 3486300.0 3790400.0 True False 1587501.2374700296 3467518.6099236337 4582955.115170539 1.0 2.184261988639298 2.8868986095874214 20.598326285801846 -8.742402922741944 0.191921455747441 3.045077717741097e-11 3.726359971620281 0.9996829173769828 0.013865145701241033 0.29156343533645884 0.05651551957551117 0.5556988402377658 0.37976908780433194 1.809660375983159e-09 8.742402922741944 3.7263599715898303 GDFILVGDLMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDFILVGDLMR 11 0 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 0 2468160.0 465090.0 778770.0 1224300.0 False True 609737.4939379664 662580.5516216836 1097621.180314867 1.0 1.0866652587532912 1.800153658299611 19.21782873726769 -6.9295654593639995 0.7503455723336849 0.9889738745659743 1.9450238543309204 0.996452313908345 0.021354267288508023 0.09286367107368612 0.07878849761489674 0.0194048669604209 0.06471309523128793 1.176073706726627e-07 6.9295654593639995 0.9560499797649461 GDGEVLEEIVTK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDGEVLEEIVTKER 14 1 F5GYV5;H7BZV4;A0A0C4DG62;F8WCT1;Q66PJ3-7;Q66PJ3-4;Q66PJ3-3;Q66PJ3-2;Q66PJ3;F8WEP2;A0A0C4DH18;Q66PJ3-5 F5GYV5 ARL6IP4 ADP-ribosylation factor-like protein 6-interacting protein 4 1 7094190.0 965590.0 0.0 6128600.0 True False 934937.873987243 0.0 4523335.805940997 1.0 0.0 4.838113773966885 19.834510976476295 -6.85279943390469 1.2214508876358408 0.46479235871417013 5.042286237782893 0.9442898089322324 0.4922071841033799 0.15440193280472245 0.44187364519245087 0.31507648273527306 0.7305564518038662 1.4034617023079232e-07 6.85279943390469 4.577493879068722 GDGEVLEEIVTK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDGEVLEEIVTKER 14 1 F5GYV5;H7BZV4;A0A0C4DG62;F8WCT1;Q66PJ3-7;Q66PJ3-4;Q66PJ3-3;Q66PJ3-2;Q66PJ3;F8WEP2;A0A0C4DH18;Q66PJ3-5 F5GYV5 ARL6IP4 ADP-ribosylation factor-like protein 6-interacting protein 4 1 6672690.0 965590.0 1933300.0 3773800.0 True False 802930.8678899399 1922884.929169995 4562884.131920271 1.0 2.394832489406262 5.682785796878491 19.61491625191057 -6.956708982562504 0.47956945324887124 0.9207592116668222 7.293843048726463 0.9996280012975101 0.03786328433538163 0.08089835631899649 0.025639277203351157 0.046318787185999404 0.27123254868592506 1.1048187025432325e-07 6.956708982562504 6.3730838370596405 GDGGIYIGSIMK(ub)GGAVAADGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDGGIYIGSIMKGGAVAADGR 21 1 I3L2N2;O14641;I3L0M7;I3L2W9;A0A3B3ITC6;Q92997-2;Q92997;O14640-2;P54792-2;P54792;O14640 I3L2N2;Q92997-2;O14640-2 DVL2;DVL3;DVL1;DVL1P1 Segment polarity protein dishevelled homolog DVL-2;Segment polarity protein dishevelled homolog DVL-3;Segment polarity protein dishevelled homolog DVL-1;Putative segment polarity protein dishevelled homolog DVL1P1 1 27399100.0 4141900.0 9810200.0 13447000.0 True False 4010417.651661439 13727464.019517146 9924827.298647087 1.0 3.422951226496353 2.4747615237867864 21.93532105852425 -10.38630408889108 6.1481773674849 0.999671400366165 2.9488563751415646 0.8492292755246663 0.3870968251666207 0.0017438137323187585 0.00017406327666118942 0.37485989667853653 0.1249349631033402 4.10861938719189e-11 10.38630408889108 1.9491849747753998 GDGGIYIGSIMK(ub)GGAVAADGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDGGIYIGSIMKGGAVAADGR 21 1 I3L2N2;O14641;I3L0M7;I3L2W9;A0A3B3ITC6;Q92997-2;Q92997;O14640-2;P54792-2;P54792;O14640 I3L2N2;Q92997-2;O14640-2 DVL2;DVL3;DVL1;DVL1P1 Segment polarity protein dishevelled homolog DVL-2;Segment polarity protein dishevelled homolog DVL-3;Segment polarity protein dishevelled homolog DVL-1;Putative segment polarity protein dishevelled homolog DVL1P1 1 12790700.0 2847300.0 3941900.0 6001500.0 True False 3900023.755389292 3767733.8238798757 4584069.304772332 1.0 0.9660797113539091 1.1753952263592713 21.89505148090879 -6.865350008423635 1.1583130147568466 0.9812597249062758 1.1866223466472672 0.9598232475785492 0.018386187152159728 0.14139678067505884 0.35748557311184637 0.012349913445522163 0.029027091340864286 1.3634838290840716e-07 6.865350008423635 0.2053626217409914 GDGGIYIGSIMK(ub)GGAVAADGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDGGIYIGSIMKGGAVAADGR 21 1 I3L2N2;O14641;I3L0M7;I3L2W9;A0A3B3ITC6;Q92997-2;Q92997;O14640-2;P54792-2;P54792;O14640 I3L2N2;Q92997-2;O14640-2 DVL2;DVL3;DVL1;DVL1P1 Segment polarity protein dishevelled homolog DVL-2;Segment polarity protein dishevelled homolog DVL-3;Segment polarity protein dishevelled homolog DVL-1;Putative segment polarity protein dishevelled homolog DVL1P1 1 21016500.0 4141900.0 7703100.0 9171500.0 True False 3444173.367281505 7661601.871354367 11089218.245775266 1.0 2.224511095793557 3.2197038485690443 21.715726333958525 -7.117351838051742 0.1638193411352175 2.1557488838155204e-16 5.327950819039332 0.999997405257084 0.0014622928639418861 0.07970614355417716 0.006058144304636329 0.0559588416968935 0.1334133638784695 7.632172225003945e-08 7.117351838051742 5.327950819039332 GDGLCCYLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDGLCCYLKR 10 1 O43719;Q5H918;Q5H919 O43719 HTATSF1 HIV Tat-specific factor 1 1 6382300.0 2070300.0 2089100.0 2222900.0 True False 2835745.8577538203 1996796.6542701367 1697896.8020625554 1.0 0.7041521893826512 0.5987478734809651 21.435296811990636 -13.999999999999998 0.14373714307358787 2.418572056827144 0.47399620349906985 0.9995884634440787 0.003445621204939407 11.939668149099655 0.11904271083312222 4.741557727841354 0.11182992407478522 1.0000000000000041e-14 13.999999999999998 -1.9445758533280741 GDGPHGSCAFQK(ub)QCIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDGPHGSCAFQKQCIK 16 1 G5E9U9;Q9H0J9 G5E9U9 PARP12 Poly [ADP-ribose] polymerase 12 1 6127200.0 1608600.0 1825100.0 2693500.0 True False 2440363.804412481 1499396.645428615 2161128.544397012 1.0 0.6144152124849253 0.8855763802468398 21.218664807152237 -10.122922415986462 5.658790925328081 1.0000027211259115 0.7499957963658546 0.5312618717011006 0.11070108317908542 3.800369776230923e-06 5.890686103605227e-07 0.10718703031082698 0.0357286209632956 7.534901580509825e-11 10.122922415986462 -0.2500069247600569 GDGPICLVLAPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDGPICLVLAPTR 13 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QRQ7 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 61688000.0 17387000.0 20660000.0 23641000.0 False True 22794525.375947498 17577608.532049246 21194856.100485 1.0 0.771132903280229 0.9298222161207863 24.4421840341558 -9.966743057077517 6.097716974520951 1.0000000748510636 0.8504775597004902 0.5420699144096044 0.06478464068210477 6.592957850365118e-08 1.1113452086574027e-08 0.0627274899257225 0.020909152870976173 1.0795852515233632e-10 9.966743057077517 -0.14952251515057335 GDGPICLVLAPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDGPICLVLAPTR 13 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QRQ7 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 28245700.0 19424000.0 4939400.0 3882300.0 False True 18807395.75216004 6911728.178630711 2865409.163496511 1.0 0.3675005444513441 0.1523554457648618 24.164796757859673 -11.209028184828288 0.20564964093452293 2.103397794179894 1.0793167915784342e-08 0.9993529981986585 0.009150932180717898 3.4873041137510445 0.11776394876481365 1.8999947728014581 0.12804218734328332 6.1797629343285936e-12 11.209028184828288 -2.103397783386726 GDGPICLVLAPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDGPICLVLAPTR 13 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QRQ7 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 84023000.0 17387000.0 32590000.0 34046000.0 False True 23815443.766007647 31150066.03928183 26005035.99937997 1.0 1.307977560499757 1.0919400140045923 24.505394095678692 -10.238157044959241 3.7308728200483063 0.9997232788136419 1.199958787028588 0.5332011152476834 0.08819695961550938 62724455.28924324 113713795.95018987 211396.4073445494 0.03227679447488232 5.778870402429869e-11 10.238157044959241 0.20023550821494607 GDGPICLVLAPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDGPICLVLAPTR 13 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QRQ7 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 30152100.0 19424000.0 2284300.0 8443800.0 False True 16151916.629101582 2271994.022501952 10209359.54027992 1.0 0.1406640508785444 0.6320834718701612 23.94520203329395 -10.642612115842692 5.482397422755111 1.0067384730740407 0.38637376155821224 0.6752128941942859 0.2006211385205698 0.01658486657939753 0.0010811379398050153 0.19496823220702508 0.0647501940322781 2.2771303105086355e-11 10.642612115842692 -0.6203647115158285 GDGPVQGIINFEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDGPVQGIINFEQK 14 0 P00441 P00441 SOD1 Superoxide dismutase [Cu-Zn] 0 145100000.0 34342000.0 61537000.0 49221000.0 False True 45022694.56840109 52355919.46934731 44128083.08117136 1.0 1.162878409905146 0.9801297657591199 25.424149067608166 -6.671649344112669 1.9314517988036661 1.1038187552445708 0.9808625902037139 0.28632594801988276 0.06916142532833415 0.4573912112056516 3.291125939152976 0.028810716754851844 0.07681191316185648 2.1298580312847152e-07 6.671649344112669 -0.12295616504085694 GDGPVQGIINFEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDGPVQGIINFEQK 14 0 P00441 P00441 SOD1 Superoxide dismutase [Cu-Zn] 0 115675000.0 34342000.0 42379000.0 38954000.0 False True 47039165.457654305 40506555.65138769 29753867.482812867 1.0 0.8611240283982629 0.6325339149479162 25.487359129131058 -6.963668059804378 0.3802248628082881 1.0156622949726044 0.46990930552682597 0.999882991916726 0.001638773654102893 0.07841595382920565 0.016472226593867986 0.002974191210277644 0.019313558842253213 1.0872563184612488e-07 6.963668059804378 -0.5457529894457784 GDGPVQGIINFEQK(ub)ESNGPVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDGPVQGIINFEQKESNGPVK 21 1 P00441 P00441 SOD1 Superoxide dismutase [Cu-Zn] 1 17612300.0 4211200.0 9235900.0 4165200.0 True False 5520923.981318806 7857939.721256227 3734225.059419658 1.0 1.4233015610874555 0.6763768296856079 22.396478305840837 -6.752974492810418 1.6390072305329528 1.248012843164418 0.674563800482167 0.661618573743395 0.17790565209799272 0.29487689514565146 1.559432898387647 0.08571710462393191 0.20743829938238073 1.7661415475034617e-07 6.752974492810418 -0.5734490426822509 GDGPVQGIINFEQK(ub)ESNGPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDGPVQGIINFEQKESNGPVK 21 1 P00441 P00441 SOD1 Superoxide dismutase [Cu-Zn] 1 12865300.0 5929500.0 6935800.0 0.0 True False 5741271.268144199 9705301.109719193 0.0 1.0 1.6904446169561191 0.0 22.45293879214476 -6.808658176686316 1.505197774905881 1.3822308310065836 2.1891059324896045e-18 0.8191262520271368 0.2951391610037434 0.2190713071606414 0.9919820943224484 0.15617520329485612 0.34814316358321007 1.5536093394532496e-07 6.808658176686316 -1.3822308310065836 GDGPVQGIINFEQK(ub)ESNGPVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDGPVQGIINFEQKESNGPVK 21 1 P00441 P00441 SOD1 Superoxide dismutase [Cu-Zn] 1 12738600.0 4211200.0 5695700.0 2831700.0 True False 5768194.443400896 5444045.140838839 2162910.7806921285 1.0 0.9438040264171572 0.3749718914497771 22.45968836736373 -6.925998425654808 0.778939150766909 1.010052790387772 0.26926559472379963 0.9956915957366356 0.018531647834915725 0.094769552201052 0.08825454606516811 0.016497331434927143 0.052647317769115215 1.1857730466622798e-07 6.925998425654808 -0.7407871956639724 down GDGPVQGIINFEQK(ub)ESNGPVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDGPVQGIINFEQKESNGPVK 21 1 P00441 P00441 SOD1 Superoxide dismutase [Cu-Zn] 1 26442700.0 7682300.0 11679000.0 7081400.0 True False 9944888.790772445 11029053.38333391 5792657.861299906 1.0 1.10901726659502 0.5824758811455724 23.245523807462313 -6.852706740231425 1.2219812036448012 1.0583373073929696 0.560304021118722 0.9441527556047279 0.053627102616499396 0.15450092465558962 0.44260154333175916 0.03431534554711116 0.07955631937626872 1.4037612822242765e-07 6.852706740231425 -0.4980332862742476 GDGVVLVAPPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDGVVLVAPPLR 12 0 P62310 P62310 LSM3 U6 snRNA-associated Sm-like protein LSm3 0 10027400.0 1054900.0 4621900.0 4350600.0 False True 1382984.1156661334 3932330.5360250887 3900441.6459020413 1.0 2.8433663781677114 2.8203083475209256 20.399353155761027 -10.127578850477727 4.227532858595096 0.999627498204906 2.8318373630818323 0.9998811824738709 0.009413402517960705 3311187.2963026147 4767542.494504237 15673.717654151716 0.003444952147306149 7.454545150674575e-11 10.127578850477727 1.8322098648769263 GDGVVLVAPPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDGVVLVAPPLR 12 0 P62310 P62310 LSM3 U6 snRNA-associated Sm-like protein LSm3 0 8591700.0 2745100.0 1126400.0 4720200.0 False True 2657958.30309177 1576177.3940984025 3483838.0170353204 1.0 0.5930030551137591 1.3107195899133846 21.34188704173564 -6.752909117049488 1.6394943839999576 0.7615165255688977 1.3124321011672564 0.6612326461563487 0.17105142817273103 0.2949951930326883 1.561009426031715 0.08239490431824678 0.19939276035726228 1.7664074305467078e-07 6.752909117049488 0.5509155755983587 GDGVVLVAPPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDGVVLVAPPLR 12 0 P62310 P62310 LSM3 U6 snRNA-associated Sm-like protein LSm3 0 12261100.0 1054900.0 6733700.0 4472500.0 False True 1444925.0376005932 6436182.868631859 3416187.6140288673 1.0 4.454336869488833 2.3642663287928793 20.46256321728392 -9.855306742731333 8.396054934436197 1.0000039751379675 3.40930159914086 0.6392153726321785 0.8532677251910924 7.49500948655713e-09 1.3406007813523e-18 0.8261729346898388 0.2753909741263172 1.3953824525654376e-10 9.855306742731333 2.4092976240028925 GDINILLIGDPSVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDINILLIGDPSVAK 15 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 17330200.0 4174500.0 8474700.0 4681000.0 False True 5472809.925915509 7210307.7941218605 4196655.023322634 1.0 1.3174782043824949 0.7668190710315239 22.383850321045724 -6.7503410327848155 1.6483604497803308 1.1865987395875677 0.7656801012595619 0.6505567073838029 0.13340903808333512 0.2994358746879229 1.600813834022577 0.06392919928054196 0.15516081381084937 1.776883551798066e-07 6.7503410327848155 -0.4209186383280058 GDINILLIGDPSVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDINILLIGDPSVAK 15 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 27184000.0 8949600.0 6798400.0 11436000.0 False True 8665499.846763372 9513036.573187659 8440568.527353913 1.0 1.0978058671065405 0.9740428915368946 23.046851539211428 -6.696060309280344 1.8450434311771284 1.0609664044254299 0.9744383223926303 0.39888371017462476 0.041315518851554045 0.4037549530478966 2.6693200399108985 0.017884006289391095 0.04621581646043972 2.0134446289293204e-07 6.696060309280344 -0.0865280820327996 GDINILLIGDPSVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDINILLIGDPSVAK 15 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 69120000.0 10773000.0 39775000.0 18572000.0 False True 16343428.611796388 32676840.486506604 14901236.059603224 1.0 1.9993871091969684 0.9117570378621646 23.962207335721697 -6.665117530524758 1.954846197662816 1.6405710273521354 0.9162513571158197 0.25752594317968514 0.4250029258419368 0.4724325250581344 3.4757380095104327 0.17533061102012246 0.4714139478420876 2.1621333193038812e-07 6.665117530524758 -0.7243196702363157 GDINILLIGDPSVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDINILLIGDPSVAK 15 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 21175700.0 4174500.0 4846200.0 12155000.0 False True 5717925.461620697 4632078.85975967 9284239.340082921 1.0 0.8100978039764 1.623707654533045 22.447060382568615 -6.845215030390732 1.2578971124387908 0.8989346915076198 1.6533621773150824 0.9330598581487689 0.08991741988575522 0.16279741248182225 0.49810448468813034 0.05599629047754289 0.12924803756184605 1.4281866514038836e-07 6.845215030390732 0.7544274858074626 GDINILLIGDPSVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDINILLIGDPSVAK 15 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 19917100.0 8949600.0 4916900.0 6050600.0 False True 7441988.934504105 4890411.683771764 7315752.485186485 1.0 0.6571377257896495 0.9830372699518086 22.827256814645704 -10.60582754973697 9.105462507615226 1.0000463381696487 0.8200874981822448 0.288936450485877 0.1330479317671537 0.00012518797252116252 5.419173512821065e-06 0.12885616447155912 0.04294103533179394 2.4784059912024813e-11 10.60582754973697 -0.17995883998740392 GDINILLIGDPSVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDINILLIGDPSVAK 15 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 40904000.0 10773000.0 16546000.0 13585000.0 False True 13945860.867577622 15625200.554897042 11112669.393871136 1.0 1.1204185028995717 0.7968435580557597 23.733333657814146 -6.805909473463359 1.4314579052538015 1.0659515757694735 0.7916864820954438 0.848930899553904 0.051900168663098725 0.2124298914155951 0.8586031661557283 0.028514047392156815 0.0660955032377755 1.5634735069966329e-07 6.805909473463359 -0.27426509367402974 GDINLLMLGDPGTAK(ub)SQLLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 GDINLLMLGDPGTAKSQLLK 20 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 22424100.0 4009900.0 7548800.0 10865400.0 True False 3882607.9194082865 10563075.206471942 8019425.784987002 1.0 2.72061341905514 2.065474019382614 21.88859459506523 -10.328193099058725 5.55154463142675 0.9997403437669873 2.3930437192188965 0.857719750530255 0.2674595399318978 0.000859703194336417 0.00010403425968585184 0.2590119634970076 0.08632219532836836 4.696852274313152e-11 10.328193099058725 1.393303375451909 GDINLLMLGDPGTAK(ub)SQLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDINLLMLGDPGTAKSQLLK 20 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 7291070.0 630170.0 0.0 6660900.0 True False 863160.8787039194 0.0 5087732.6055416195 1.0 0.0 5.894303983263367 19.71926995304998 -6.863227731105163 1.1692434648203365 0.4520077186349517 6.197946421562644 0.9574487260021929 0.5312652318938446 0.14351800508737692 0.37100494403950335 0.35387602066569185 0.8293333117757388 1.3701631049919418e-07 6.863227731105163 5.745938702927693 up GDINLLMLGDPGTAK(ub)SQLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDINLLMLGDPGTAKSQLLK 20 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 14516300.0 3122600.0 6108200.0 5285500.0 True False 2596580.2546351226 6075293.914217226 6390673.612609194 1.0 2.3397289197483095 2.4611885579894106 21.30818138599763 -10.645963173295097 0.46396541048560613 2.409060136484124e-21 2.461046365825352 0.9995734229924056 0.013673645287864578 2.1533400806602034 0.22163816956072915 2.4989461790066843 0.026507380109707632 2.2596273708647432e-11 10.645963173295097 2.461046365825352 GDINQK(ub)LQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDINQKLQK 9 1 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4;F5GYR7;F5H592 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 5741400.0 1255700.0 2017800.0 2467900.0 True False 1646234.8602160986 1716752.1053227957 2212545.3817684115 1.0 1.0428354706918552 1.3440034804499124 20.650738741959895 -6.932579444662971 0.7252992718302389 0.9958299533690562 1.4101007975296143 0.9970215191283641 0.008353895776633966 0.09132011824745496 0.071277730806167 0.007731159944243853 0.026874372209393375 1.167940061266488e-07 6.932579444662971 0.41427084416055804 GDINQK(ub)LQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDINQKLQK 9 1 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4;F5GYR7;F5H592 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 8364800.0 1729900.0 2424100.0 4210800.0 True False 1674985.2713993846 3392055.771514504 3107865.158707753 1.0 2.0251257306164696 1.8554582012003324 20.67571697894086 -10.183845626820492 4.602222107438729 0.999835130998472 1.9402919659184106 0.9761627838701119 0.06926647886554117 48615718.14928837 26.288077354194566 84937.4532852688 0.023711758090895034 6.548689106893259e-11 10.183845626820492 0.9404568349199386 GDINQK(ub)LQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDINQKLQK 9 1 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4;F5GYR7;F5H592 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 11673900.0 2227200.0 1977500.0 7469200.0 True False 3378825.23013023 1624599.6747219784 5992909.3461333485 1.0 0.4808179068378039 1.7736665669157337 21.68809029829725 -6.7977202558410665 1.4652930277291993 0.7127117388603024 1.7905075598465234 0.825390436814412 0.22196916693555285 0.22402702314560166 0.949855663478035 0.1191883342415147 0.2775708468995264 1.5932346543722477e-07 6.7977202558410665 1.077795820986221 GDINQK(ub)LQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDINQKLQK 9 1 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4;F5GYR7;F5H592 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 8053300.0 1729900.0 2651300.0 3672100.0 True False 1438488.4975639838 2637016.9206581553 4439919.132127934 1.0 1.8331859622957194 3.086516951401933 20.456122254375135 -6.965209994009485 0.35442953314637093 0.8848896773261492 4.077394499044717 0.9999174093634678 0.007793396738256511 0.07788977539053105 0.01460906441807096 0.017019850447585607 0.10741824210676082 1.0834029305330035e-07 6.965209994009485 3.1925048217185674 GDINQK(ub)LQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDINQKLQK 9 1 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4;F5GYR7;F5H592 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 8384400.0 2227200.0 1108800.0 5048400.0 True False 2883154.304675478 1047094.305286465 4129643.000958346 1.0 0.3631766442706311 1.4323350624215618 21.4592166203897 -6.745383268443641 1.6671776385248491 0.6234698840305642 1.4337027822069093 0.6287750108884822 0.2675573137844955 0.30816365065403095 1.6837554936931736 0.12686431258711459 0.30947025216299107 1.797284097079515e-07 6.745383268443641 0.810232898176345 GDINVCIVGDPSTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDINVCIVGDPSTAK 15 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 30031400.0 7098400.0 11423000.0 11510000.0 False True 9306071.141003393 9718732.926505243 10319055.611716183 1.0 1.0443432872207075 1.1088520015981276 23.149740785258846 -6.965761626524462 0.34473859796708034 0.9933762466293957 1.161978315980503 0.9999279708578799 0.0003792578989504983 0.0777035140260427 0.013954422503677734 0.0008980487121494651 0.00556459901061087 1.0820276865148708e-07 6.965761626524462 0.16860206935110733 GDINVCIVGDPSTAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDINVCIVGDPSTAK 15 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 88479000.0 10970000.0 54006000.0 23503000.0 False True 16642292.014425553 44368207.349196024 18857621.748269133 1.0 2.6659913977436296 1.133114461152546 23.98835080262644 -6.626431040801289 2.093982400919695 2.1004320045275855 1.139246636864514 0.10469536685590075 0.7152710886990101 0.568268228839794 4.743781011172609 0.2798747226884217 0.7922950270895216 2.3635726678820483e-07 6.626431040801289 -0.9611853676630715 GDINVCIVGDPSTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDINVCIVGDPSTAK 15 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 25190300.0 7098400.0 8150400.0 9941500.0 False True 9722870.307047158 7790288.378231443 7593522.45161946 1.0 0.8012333942771019 0.7809959622844767 23.212950846781737 -13.999999999999998 0.32286945694621 3.073153119145898 0.7771056258624128 0.9996998526008242 0.001711944940807279 18.23882717551627 0.18134305782974056 25.580675918864163 0.006663090174229512 1.0000000000000041e-14 13.999999999999998 -2.2960474932834853 GDINVCIVGDPSTAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDINVCIVGDPSTAK 15 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 7974600.0 4016000.0 0.0 3958600.0 False True 3339481.938965814 0.0 4786324.957501603 1.0 0.0 1.4332537336566205 21.67119288098904 -6.719085852473987 1.7624244599631618 0.39103246805091774 1.43093692961816 0.5083060531483607 0.42085032036437536 0.3570834632180528 2.1671121122994226 0.18963256184395078 0.4765936689083913 1.9094757510718492e-07 6.719085852473987 1.0399044615672421 GDINVCIVGDPSTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDINVCIVGDPSTAK 15 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 42941000.0 10970000.0 16858000.0 15113000.0 False True 14200881.251028182 15919837.480627036 12362589.072475135 1.0 1.1210457435149948 0.8705508379333888 23.759477124718888 -6.775305676907786 1.5541294411731807 1.0689571093836812 0.8688498770081414 0.750439395221971 0.051096685616395805 0.2579373899216315 1.2301579313476139 0.025904493199217327 0.06136870441665187 1.6776228125406296e-07 6.775305676907786 -0.20010723237553973 GDINVCIVGDPSTAK(ub)SQFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDINVCIVGDPSTAKSQFLK 20 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 65729000.0 10414000.0 16639000.0 38676000.0 True False 15798799.36538085 13669640.448899629 31031671.647706997 1.0 0.8652328656602384 1.9641791081735749 23.913311588726135 -6.8762163162048315 1.1007263936644125 0.9200125148022855 2.036610869497672 0.9705011769659334 0.08405309889085331 0.1310323832416249 0.29301317274579747 0.059011110288137734 0.14142428005879523 1.3297919016442904e-07 6.8762163162048315 1.1165983546953866 GDINVCIVGDPSTAK(ub)SQFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDINVCIVGDPSTAKSQFLK 20 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 50344000.0 10414000.0 9794000.0 30136000.0 True False 13481128.290629685 9248955.290382063 24651557.221472263 1.0 0.6860668551615762 1.8285974801238853 23.684437910818584 -6.833443875074054 1.3123682091278426 0.8326110783730797 1.8615812354821253 0.9126050296387948 0.14247788821978968 0.17659738822942767 0.5936068951445024 0.08520739470478568 0.1961012669835324 1.4674257136274844e-07 6.833443875074054 1.0289701571090455 GDINVLLCGDPGTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDINVLLCGDPGTAK 15 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 37034500.0 9217500.0 13868000.0 13949000.0 False True 12084231.762396969 11798948.457040621 12505691.288256228 1.0 0.9763921024550294 1.0348768158494555 23.52662242297414 -6.797137985822008 1.467610099132507 0.9869268686490122 1.0356278916383495 0.823653221465652 0.010088375401368508 0.22486781752643706 0.9564788000166717 0.005408594647039946 0.01260073995960731 1.5953721785184277e-07 6.797137985822008 0.048701022989337206 GDINVLLCGDPGTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDINVLLCGDPGTAK 15 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 14985800.0 6592600.0 2660900.0 5732300.0 False True 6383321.521606795 3723411.2464101897 4230838.664686156 1.0 0.5833031022809801 0.6627957953183564 22.60587588607376 -10.836249684553412 7.3491067266707715 1.0235974914793073 0.6230494487996685 0.9677226524038194 0.032452756036877486 0.011500716886070147 0.0002562547824502891 0.02880104912127362 0.010474081972446562 1.457975799928896e-11 10.836249684553412 -0.40054804267963884 GDINVLLCGDPGTAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDINVLLCGDPGTAK 15 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 70284600.0 8061000.0 53687000.0 8536600.0 False True 12229126.338038698 44106135.391554475 6849337.268275298 1.0 3.6066464743570714 0.5600839404995297 23.543818004070207 -6.680153544356267 1.9011332589118868 2.6490128137313445 0.5716101598032204 0.3249009744155441 1.10471926603379 0.4381931041252944 3.062130959513786 0.4662227445130184 1.2294833351405863 2.0885575929717354e-07 6.680153544356267 -2.0774026539281243 GDINVLLCGDPGTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDINVLLCGDPGTAK 15 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 34498500.0 9217500.0 10743000.0 14538000.0 False True 12625458.843571376 10268338.737649722 11104423.81950848 1.0 0.8133042026332492 0.879526356791589 23.58983248449703 -10.57448829339913 8.7686839959148 1.00002852136563 0.8464152806264074 0.8776279304111884 0.027035081225976615 1.5076982674391944e-05 7.316247259256827e-07 0.026181457119298878 0.00872553494596435 2.663861901381271e-11 10.57448829339913 -0.15361324073922256 GDINVLLCGDPGTAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDINVLLCGDPGTAK 15 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 12874900.0 6592600.0 1638000.0 4644300.0 False True 5482039.00169971 1629175.7688824583 5615401.657183021 1.0 0.2971842718334056 1.0243271993216323 22.386281161508037 -9.265924407542093 14.595753236701832 0.999986736808421 0.6607557355775187 0.2249371206247449 0.29685485716872173 0.0 0.0 0.2874284794691836 0.09580949315639452 5.420952382395309e-10 9.265924407542093 -0.33923100123090233 GDINVLLCGDPGTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDINVLLCGDPGTAK 15 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 33236300.0 8061000.0 15591000.0 9584300.0 False True 10435123.406065477 14723347.14440953 7840055.743222617 1.0 1.4109413536836084 0.7513141376618064 23.314944326162657 -6.738271320003227 1.6933496225621738 1.2450039406251998 0.7510968995511411 0.5969986691344886 0.17266813701584524 0.32096234198729007 1.8064720614896277 0.08069477897132948 0.19836994865488508 1.8269584902527283e-07 6.738271320003227 -0.4939070410740587 GDINVLLCGDPGTAK(ub)SQFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDINVLLCGDPGTAKSQFLK 20 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 7155100.0 3778500.0 1616000.0 1760600.0 True False 3658553.5857463325 2261277.2273286697 1299446.0431321538 1.0 0.6180795700624887 0.3551802680148721 21.80284195905939 -8.14033123418239 0.19132673689666552 1.2832369393536587 3.098994169488631e-13 0.9998363838450063 0.0033863147385332637 0.08849649360653497 0.03749201599399565 0.0983729571656776 0.11287863172838566 7.238836471195367e-09 8.14033123418239 -1.2832369393533487 down GDINVLLCGDPGTAK(ub)SQFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDINVLLCGDPGTAKSQFLK 20 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 11051200.0 3778500.0 1531000.0 5741700.0 True False 3141990.1659318563 1522752.1991202938 6942262.9233787125 1.0 0.4846457559387916 2.209511346869466 21.583247234493665 -6.826617989806705 1.3428361237191375 0.7239083271282359 2.252835294316655 0.8989508659543415 0.22980708798785515 0.18503099073368073 0.6536908652103436 0.13440825444358134 0.3094075343397375 1.490671712402598e-07 6.826617989806705 1.5289269671884194 up GDK(ub)ADK(ub)ASASAPAPASATEILLTPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDKADKASASAPAPASATEILLTPAR 26 2 Q9NQX7-2;Q9NQX7-3;Q9NQX7;C9JG41 Q9NQX7-2 ITM2C Integral membrane protein 2C;CT-BRI3 2 35980000.0 12508000.0 11784000.0 11688000.0 True False 16398109.127644312 10025873.13367224 10478637.879212752 1.0 0.6114042207933834 0.6390150106726404 23.967026130918 -10.757546805566667 6.936393567901331 1.0077989766528375 0.6252096157333402 0.9959460538596403 0.01127205776656362 0.0013665833273675183 4.776719795734528e-05 0.0109710579470602 0.00363804100061573 1.7476449019359716e-11 10.757546805566667 -0.38258936091949725 GDK(ub)EEQEVSWTQYTQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDKEEQEVSWTQYTQR 16 1 E7EQN5;P98171;P98171-2;A0A0B4J1X7;E9PCM6 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 1 37654800.0 4211100.0 9025700.0 24418000.0 True False 6388546.572647907 7414993.316884033 19591771.597210404 1.0 1.1606698382118372 3.066702476756002 22.607056317251146 -6.923560322025877 0.7978806635003843 0.9630930672445238 3.400726847808706 0.9951140764207215 0.06561295729506593 0.09612180259009419 0.0950901578890483 0.057625755452415994 0.1789558748608256 1.19244862729567e-07 6.923560322025877 2.437633780564182 up GDK(ub)EEQEVSWTQYTQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDKEEQEVSWTQYTQR 16 1 E7EQN5;P98171;P98171-2;A0A0B4J1X7;E9PCM6 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 1 27317000.0 4211100.0 4800900.0 18305000.0 True False 5451351.963190963 4533725.69466973 14973677.825160952 1.0 0.8316699646771482 2.7467824360392377 22.378182639343596 -6.8854829141846325 1.0487657527232876 0.8856817574260248 2.897611705736538 0.9778448576114743 0.1288780884102763 0.12288334942913222 0.2438863272771264 0.09414583682817596 0.23119111964531583 1.3017185261882756e-07 6.8854829141846325 2.011929948310513 up GDK(ub)VDILYNNIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDKVDILYNNIK 12 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 1 14494000.0 4746500.0 4113000.0 5634500.0 True False 6222707.465171383 3499356.432348426 5051495.989940476 1.0 0.5623527141416166 0.8117842624313932 22.56911099480921 -10.176981131669939 5.472780163009867 1.0000098004938784 0.6870684882864608 0.6772760724777995 0.1018300031772115 1.2177246089546099e-05 1.8312547057343327e-06 0.09859956340881554 0.03286549220410983 6.65302060244272e-11 10.176981131669939 -0.3129413122074176 GDK(ub)VDILYNNIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDKVDILYNNIK 12 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 1 5088700.0 1006800.0 4081900.0 0.0 True False 974839.6850944579 5711823.95682729 0.0 1.0 5.8592443908085645 0.0 19.89480545787761 -6.686566351638376 1.8791746429709082 4.056263509804936 0.02134969611181492 0.3541936498454936 2.0565819611377276 0.42407015406100584 2.900803917748714 0.8765135547575493 2.2919600130046707 2.057944453165351e-07 6.686566351638376 -4.034913813693121 GDK(ub)VDILYNNIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDKVDILYNNIK 12 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 1 37203000.0 3588500.0 12124200.0 21490300.0 True False 5444016.854490988 9960541.783193035 17242732.78546691 1.0 1.8296309598997997 3.1672813009832415 22.376240102707765 -6.964029420961295 0.3743403931719273 0.9020644427272114 4.141728409649219 0.9998917130376997 0.0092911345049006 0.07829193277159212 0.01603109348395063 0.01752350073958286 0.11334750609583205 1.0863520270025549e-07 6.964029420961295 3.2396639669220075 GDK(ub)VDILYNNIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDKVDILYNNIK 12 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 1 14147300.0 4746500.0 4343600.0 5057200.0 True False 6501409.319339468 4151685.3896356085 3862793.516303364 1.0 0.6385823727919676 0.5941471035845836 22.632321056332103 -13.999999999999998 0.29562332875503405 4.21517663037963 0.582710063097214 0.9996400497862047 0.0034483144745815187 16.30874697154596 0.17255397769871345 31.993141493010633 0.01636685596033117 1.0000000000000041e-14 13.999999999999998 -3.6324665672824157 GDK(ub)VDILYNNIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDKVDILYNNIK 12 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 1 9781100.0 1006800.0 6385700.0 2388600.0 True False 837198.8088024862 6351298.966637789 2888045.216361429 1.0 7.586368852725162 3.449652801695258 19.675210733311886 -9.62358190739294 10.030904750705703 0.9999999087142708 5.51801082721021 0.6139676829136552 1.6888072559673812 0.0 0.0 1.6351805943289783 0.5450601981096593 2.3791295577999026e-10 9.62358190739294 4.518010918495939 GDK(ub)VDILYNNIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDKVDILYNNIK 12 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 1 37487500.0 3588500.0 11373200.0 22525800.0 True False 4645383.989910179 10740271.422153698 18426335.534226164 1.0 2.312030920475396 3.9665903990387776 22.147366424800214 -6.967980057411135 0.30257188504960547 0.7216749047509957 5.608980937745155 0.9999620612335723 0.0074762921189176134 0.07696374931977595 0.011363861765525913 0.027105541388556215 0.14799071059695654 1.0765146455175823e-07 6.967980057411135 4.887306032994159 GDKADK(ub)ASASAPAPASATEILLTPAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDKADKASASAPAPASATEILLTPAR 26 2 Q9NQX7-2;Q9NQX7-3;Q9NQX7;C9JG41 Q9NQX7-2 ITM2C Integral membrane protein 2C;CT-BRI3 1 32253400.0 14908000.0 9181100.0 8164300.0 True False 22616525.920789074 7542660.972738297 6550622.526460196 1.0 0.33350219212072246 0.28963876014392087 24.430874001064733 -13.837303765563922 0.38795332068822563 9.999810840292266 0.28627137952101617 0.999816806915678 0.004399137554515271 21.978627876067208 0.20364545694899783 164.89717056559763 0.01161760285653648 1.4544414214039904e-14 13.837303765563922 -9.71353946077125 GDKADK(ub)ASASAPAPASATEILLTPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDKADKASASAPAPASATEILLTPAR 26 2 Q9NQX7-2;Q9NQX7-3;Q9NQX7;C9JG41 Q9NQX7-2 ITM2C Integral membrane protein 2C;CT-BRI3 1 29547700.0 14908000.0 8823800.0 5815900.0 True False 19298699.880613323 8332747.773256422 4757465.8761733705 1.0 0.43177767542917006 0.2465174289254855 24.202000323157183 -13.999999999999998 0.15671226317970863 3.7798552690697185 0.057625504069032045 0.9995454048554647 0.006835123217903456 11.989379324582432 0.12498117577474947 10.134207636232874 0.17147579745525948 1.0000000000000041e-14 13.999999999999998 -3.7222297650006864 GDLAPLWK(ub)GIGHVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDLAPLWKGIGHVIK 15 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 1 5865700.0 2304600.0 1860200.0 1700900.0 True False 3021352.9177781492 1582665.4110028096 1524907.184184889 1.0 0.5238267273214393 0.5047100506571339 21.52676328135782 GDLDLELVLLCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDLDLELVLLCK 12 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7ER69;K7EJ09;K7EKY0 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 65349000.0 13942000.0 30283000.0 21124000.0 False True 21151033.29672935 24878762.047841065 16948832.141021907 1.0 1.1762433399264776 0.8013240725994583 24.334224809620736 -6.778846753847954 1.5401191959405944 1.0999404771246997 0.7984473772596798 0.7633906648613202 0.07449670182020852 0.25235855918127886 1.182207118048407 0.03809915943859257 0.0899942424524117 1.6639997095620144e-07 6.778846753847954 -0.3014930998650198 GDLDLELVLLCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDLDLELVLLCK 12 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7ER69;K7EJ09;K7EKY0 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 36854000.0 13942000.0 6410000.0 16502000.0 False True 18048193.837906547 6053277.865157153 13498805.324818667 1.0 0.3353952156942973 0.7479310919449005 24.105351131713185 -9.173620478415323 9.3517783286595 1.00000010325134 0.5416633442905123 0.6220466920287264 0.16841706623638286 0.0 0.0 0.163069123186857 0.054356374395618995 6.70470264536055e-10 9.173620478415323 -0.4583367589608276 GDLGIEIPAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDLGIEIPAEK 11 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70;P30613-2;P30613 P14618 PKM;PKLR Pyruvate kinase PKM;Pyruvate kinase;Pyruvate kinase PKLR 0 148535500.0 9714500.0 65847000.0 72974000.0 False True 12735803.575351836 56022884.269595735 65423350.49603617 1.0 4.398849584805101 5.136962902180187 23.6023866546521 -9.587370980308187 0.43546447992553067 1.989090199733295e-20 5.1891030584407805 0.9984319823949174 0.07133961843778204 0.9087592893701065 0.18479069759373268 1.5708526649721646 0.1705356731439591 2.586002972167667e-10 9.587370980308187 5.1891030584407805 GDLGIEIPAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDLGIEIPAEK 11 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70;P30613-2;P30613 P14618 PKM;PKLR Pyruvate kinase PKM;Pyruvate kinase;Pyruvate kinase PKLR 0 137527000.0 45047000.0 16761000.0 75719000.0 False True 43617007.6424811 23453754.707460325 55885922.37869107 1.0 0.5377203979627747 1.2812874013911162 25.378387461071533 -6.738540465624728 1.691982602901683 0.7244962397413028 1.2815968100343091 0.5985070309953121 0.19423622429687926 0.3204074118107576 1.8004743274379347 0.0908375564230362 0.22327028327258513 1.8258266187601405e-07 6.738540465624728 0.5571005702930063 GDLGIEIPAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDLGIEIPAEK 11 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70;P30613-2;P30613 P14618 PKM;PKLR Pyruvate kinase PKM;Pyruvate kinase;Pyruvate kinase PKLR 0 519502300.0 7167600.0 502660000.0 9674700.0 False True 10873773.221749919 412956395.6994947 7762491.304428347 1.0 37.977286014526385 0.7138728338477458 23.374349309611336 -3.5167884521390316 15.336646311980346 9.999999999999998 18.163235033566668 0.0 17.79476224889939 0.0 0.0 6.0122590488392245 0.0 0.0003042366622728661 3.5167884521390316 8.16323503356667 GDLGIEIPAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDLGIEIPAEK 11 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70;P30613-2;P30613 P14618 PKM;PKLR Pyruvate kinase PKM;Pyruvate kinase;Pyruvate kinase PKLR 0 159356500.0 9714500.0 78445000.0 71197000.0 False True 13306213.174491385 74979040.5170747 54381734.948242284 1.0 5.63488947109407 4.086943011892711 23.665596716174992 -9.520283579972503 7.019783023251461 0.9999999998417298 4.860916241501453 0.8924133396024352 0.631946495732084 0.0 0.0 0.611879558842343 0.20395985446706694 3.0179804351967345e-10 9.520283579972503 3.8609162416597234 GDLGIEIPAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDLGIEIPAEK 11 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70;P30613-2;P30613 P14618 PKM;PKLR Pyruvate kinase PKM;Pyruvate kinase;Pyruvate kinase PKLR 0 56212500.0 45047000.0 7229400.0 3936100.0 False True 37458576.42046636 7190453.787276447 4759120.311529854 1.0 0.19195747608143954 0.1270502183027329 25.15879273650581 -13.811018208557972 0.3590698937031754 9.999988596526416 0.11905431404881721 0.9997664464625834 0.006068642926827841 18.788555342389817 0.19320274283896363 128.76868258475932 0.01879583288167175 1.5451896533935735e-14 13.811018208557972 -9.880934282477599 GDLGIEIPAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDLGIEIPAEK 11 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70;P30613-2;P30613 P14618 PKM;PKLR Pyruvate kinase PKM;Pyruvate kinase;Pyruvate kinase PKLR 0 29292600.0 7167600.0 11392000.0 10733000.0 False True 9278599.49451865 10758025.185627185 8779704.129879942 1.0 1.1594449347644014 0.946231609098611 23.145475631703786 -6.706542609370715 1.8072682640707647 1.098370597170396 0.9467778760360328 0.4486417025141226 0.06722740310633595 0.3821446931746135 2.4308120876787784 0.029624661265781078 0.07558515615198727 1.965429139522838e-07 6.706542609370715 -0.15159272113436328 GDLGIEIPAEK(ub)VFLAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDLGIEIPAEKVFLAQK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70;P30613-2;P30613 P14618 PKM;PKLR Pyruvate kinase PKM;Pyruvate kinase;Pyruvate kinase PKLR 1 23771300.0 4621200.0 11001700.0 8148400.0 True False 6058437.951764465 9360289.24429071 7305281.732972037 1.0 1.5450004306084557 1.2058028473898028 22.53051444062374 -10.165362830090341 4.676963402902606 0.9999531271298295 1.3754016390024604 0.6202264484922939 0.13847683348992174 6.769015741122695e-05 1.2079613603032345e-05 0.13409632318745068 0.04469320582688304 6.833405138489779e-11 10.165362830090341 0.37544851187263084 GDLGIEIPAEK(ub)VFLAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDLGIEIPAEKVFLAQK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70;P30613-2;P30613 P14618 PKM;PKLR Pyruvate kinase PKM;Pyruvate kinase;Pyruvate kinase PKLR 1 66831000.0 20283500.0 20629600.0 25917900.0 True False 19639611.39512654 28867106.86194279 19129224.469666515 1.0 1.4698410412084835 0.9740123714674581 24.22726304784223 -8.825103558332689 18.642396408427576 0.9999999955190958 1.2219267063379708 0.2108042413473834 0.20242120678474496 0.0 0.0 0.19599349069913122 0.06533116356637707 1.4958789184337037e-09 8.825103558332689 0.22192671081887505 GDLGIEIPAEK(ub)VFLAQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDLGIEIPAEKVFLAQK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70;P30613-2;P30613 P14618 PKM;PKLR Pyruvate kinase PKM;Pyruvate kinase;Pyruvate kinase PKLR 1 168582700.0 36796800.0 6466900.0 125319000.0 True False 55823435.80641875 5312831.1688796785 100549644.72073114 1.0 0.09517205618269725 1.80120845784934 25.734367585970194 -6.762612126948471 1.602597269781469 0.4761335934101869 1.8082669735972314 0.7015481640205097 0.3807296055657297 0.2785548432704502 1.4105693433388788 0.18739195882956922 0.4491858614238105 1.7273799447985285e-07 6.762612126948471 1.3321333801870445 GDLGIEIPAEK(ub)VFLAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDLGIEIPAEKVFLAQK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70;P30613-2;P30613 P14618 PKM;PKLR Pyruvate kinase PKM;Pyruvate kinase;Pyruvate kinase PKLR 1 30359300.0 4621200.0 12804900.0 12933200.0 True False 6329782.523234297 12239137.177858245 9878644.527615009 1.0 1.9335794133420678 1.5606609692124729 22.59372450214663 -10.223308152929768 5.575848968438288 0.9999651138121866 1.7471201912772982 0.842561893616324 0.15224331729847304 6.603066413421061e-05 9.197447687024146e-06 0.14741581014285407 0.049136319372345395 5.979871437071292e-11 10.223308152929768 0.7471550774651117 GDLGIEIPAEK(ub)VFLAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDLGIEIPAEKVFLAQK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70;P30613-2;P30613 P14618 PKM;PKLR Pyruvate kinase PKM;Pyruvate kinase;Pyruvate kinase PKLR 1 55390800.0 20283500.0 17862100.0 17245200.0 True False 16866628.961407624 17765873.321950734 20851091.58720423 1.0 1.0533150022212894 1.2362334901012773 24.007668323276505 -6.94840181581665 0.5761287744700962 0.9977802956148439 1.3007555659784715 0.999069769265104 0.003085473538138009 0.08413404313406213 0.03866878467576779 0.0032464732242992174 0.015264397925114468 1.1261550383623292e-07 6.94840181581665 0.3029752703636276 GDLGIEIPAEK(ub)VFLAQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDLGIEIPAEKVFLAQK 17 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70;P30613-2;P30613 P14618 PKM;PKLR Pyruvate kinase PKM;Pyruvate kinase;Pyruvate kinase PKLR 1 147961200.0 36796800.0 6928400.0 104236000.0 True False 47634182.97336675 6542828.449446927 85266117.55167845 1.0 0.13735573995475384 1.7900195244107049 25.505493908062643 -6.764860752552571 1.594148671586587 0.5019725226244843 1.7975585571422346 0.7105159284172633 0.3631290157081485 0.2748196077663129 1.3774643636893333 0.17963879904119218 0.42965858459364165 1.7184592868844757e-07 6.764860752552571 1.2955860345177501 GDLLEGANAYHCEKCNK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDLLEGANAYHCEKCNK 17 1 Q93008;Q93008-3 Q93008 USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X 1 7192700.0 2271700.0 1716300.0 3204700.0 True False 3111608.8803841705 1640468.1909548757 2447815.862868267 1.0 0.5272089950946334 0.7866720905379505 21.569229298738275 -10.102912738484868 5.292319836545278 1.000006133335008 0.6569405428159955 0.6997821440179983 0.10592536515423633 7.665690181099243e-06 1.299534104191941e-06 0.10256362717711089 0.03418726459845802 7.89018636890716e-11 10.102912738484868 -0.34306559051901264 GDLNDCFIPCTPK(ub)GCLELIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDLNDCFIPCTPKGCLELIK 20 1 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 1 52494000.0 20783000.0 13095000.0 18616000.0 True False 31529330.440821 10758094.938298 14936539.440317329 1.0 0.34120911506479384 0.47373474893012646 24.910191197380144 -9.8270242885006 6.510219636306203 1.00000001368925 0.4074719320004607 0.9638384176385261 0.054103363468470396 1.0803063238681521e-08 1.9184672284172194e-09 0.05238535798286462 0.017461785473887208 1.4892777855269132e-10 9.8270242885006 -0.5925280816887892 GDLNDCFIPCTPK(ub)GCLELIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDLNDCFIPCTPKGCLELIK 20 1 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 1 42829000.0 20783000.0 6897000.0 15149000.0 True False 26904003.194176733 6513175.887049748 12392037.441866314 1.0 0.24208947047922963 0.46060199117685663 24.681317519472593 -10.088548108716028 5.105579616964496 1.0000132023079562 0.35134573082935333 0.9215644292594023 0.0892073630282099 50586535.650110565 99958235.12746036 5544.595446576074 0.030538044351782815 8.155524397865198e-11 10.088548108716028 -0.6486674714786029 GDNITLLQSVSN ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDNITLLQSVSN 12 0 P62304;A6NHK2 P62304 SNRPE Small nuclear ribonucleoprotein E 0 5730700.0 1575600.0 1496500.0 2658600.0 False True 2065626.8581321044 1273228.0333113105 2383513.575091978 1.0 0.6163882059815291 1.1538935823323535 20.97814823371964 -6.715101893837039 1.777190108044593 0.7654018876668631 1.1528213933595153 0.4892360067617155 0.1615292946848675 0.3649010928321328 2.2496398900627956 0.07224916343509176 0.18240851024190757 1.9270727318268432e-07 6.715101893837039 0.38741950569265216 GDNITLLQSVSN ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDNITLLQSVSN 12 0 P62304;A6NHK2 P62304 SNRPE Small nuclear ribonucleoprotein E 0 5204700.0 1575600.0 1669200.0 1959900.0 False True 2158141.8989889957 1595449.2246937465 1497011.9854075306 1.0 0.7392698438601982 0.6936578109663788 21.04135829524253 -13.999999999999998 0.24523324876618569 2.7705925970608276 0.6744679991552112 0.9995339601968081 0.0029133126879462927 13.814012776383944 0.15671294302319552 12.01474905681366 0.021622483899020495 1.0000000000000041e-14 13.999999999999998 -2.0961245979056162 GDNPFPK(ub)NADGTICYDSTHYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDNPFPKNADGTICYDSTHYK 21 1 P14550;Q5T621 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 1 15657000.0 2631900.0 3890400.0 9134700.0 True False 3450446.387355856 3309967.4846604248 8189528.870229701 1.0 0.9592867452715058 2.3734693865234915 21.71835158604551 -6.900269958347587 0.9595425193770141 0.941638194477791 2.522737182246652 0.9867006318744286 0.07579782094736555 0.11120742443741734 0.17629388287561198 0.05921457841616908 0.1542788563277236 1.2581431043233046e-07 6.900269958347587 1.5810989877688613 up GDNPFPK(ub)NADGTICYDSTHYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDNPFPKNADGTICYDSTHYK 21 1 P14550;Q5T621 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 1 106898700.0 12188700.0 20228000.0 74482000.0 True False 18491149.01332986 16618155.357914653 59760600.05337976 1.0 0.8987086387079025 3.231848924601693 24.140331538728066 -6.896751570907024 0.9815829055201286 0.8941628843380448 3.4612114626856 0.9848794820712429 0.13240589781351586 0.11383581451461604 0.1912146533953256 0.10175503757656501 0.26068550408762864 1.2683772070853136e-07 6.896751570907024 2.5670485783475554 up GDNPFPK(ub)NADGTICYDSTHYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDNPFPKNADGTICYDSTHYK 21 1 P14550;Q5T621 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 1 26230000.0 2631900.0 3944600.0 19653500.0 True False 3604984.554423165 3770314.5289521636 15011748.076538023 1.0 1.0458614931723205 4.1641643257858725 21.781561647568402 -6.91010218766117 0.8950511861487414 0.9037630900849705 4.568017543932011 0.9909597816536907 0.14080502235181894 0.10435016115123909 0.13840570956245063 0.11533725032878159 0.31860370097868956 1.2299793278095193e-07 6.91010218766117 3.6642544538470405 up GDNPFPK(ub)NADGTICYDSTHYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDNPFPKNADGTICYDSTHYK 21 1 P14550;Q5T621 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 1 117655700.0 12188700.0 22057000.0 83410000.0 True False 15778512.425196633 20829508.560338736 68230235.85887323 1.0 1.320118652445093 4.3242502220879 23.911457860820516 -6.927253994241627 0.7690001578495832 0.9493632360871825 4.8999585957627 0.9959704475813187 0.09504852211915006 0.09408896207283864 0.08485128061302231 0.08521913070235167 0.2760401876166952 1.1823498640185934e-07 6.927253994241627 3.9505953596755177 up GDNSSVSSLCISPDGK(ub)MLLSAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDNSSVSSLCISPDGKMLLSAGR 23 1 Q15061;C9JEE7 Q15061 WDR43 WD repeat-containing protein 43 1 47056000.0 12552000.0 17127000.0 17377000.0 True False 16455793.553740894 14571718.360523127 15578994.731954161 1.0 0.8855068771332841 0.946717925275174 23.972092263961056 -10.137016878990435 4.414398519469742 1.0000116347839383 0.9161124012871509 0.714630787892526 0.024989305786584915 3.1991416711808776e-06 6.254149376796638e-07 0.02419954215994961 0.008065263758406934 7.294291602119367e-11 10.137016878990435 -0.0838992334967874 GDNSSVSSLCISPDGK(ub)MLLSAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDNSSVSSLCISPDGKMLLSAGR 23 1 Q15061;C9JEE7 Q15061 WDR43 WD repeat-containing protein 43 1 40395600.0 21891000.0 11089000.0 7415600.0 True False 21196082.18752758 15516895.528371075 5473231.896768599 1.0 0.732064321655711 0.2582190354021752 24.337294290747156 -7.066549345588218 0.4261680684923127 1.0208266805966548 3.809119933403295e-18 0.9997913101863343 0.0044305468287211495 0.07404309496429969 0.020786366421223848 0.006538687406400187 0.03704704754084137 8.579276293745861e-08 7.066549345588218 -1.0208266805966548 down GDNSSVSSLCISPDGK(ub)MLLSAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDNSSVSSLCISPDGKMLLSAGR 23 1 Q15061;C9JEE7 Q15061 WDR43 WD repeat-containing protein 43 1 159892000.0 40282000.0 38592000.0 81018000.0 True False 61110739.00866824 31704956.079327736 65004756.78854918 1.0 0.5188115312241692 1.0637206789354747 25.86492259177052 -6.673619315911771 1.9247152113195032 0.6938140598731427 1.0615470288946345 0.29507761430111257 0.2042306332372726 0.4528752812653207 3.2378352712378775 0.08532344440983697 0.22687816350563328 2.1202188146659706e-07 6.673619315911771 0.3677329690214918 GDNSSVSSLCISPDGK(ub)MLLSAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GDNSSVSSLCISPDGKMLLSAGR 23 1 Q15061;C9JEE7 Q15061 WDR43 WD repeat-containing protein 43 1 85942200.0 17947100.0 18112400.0 49882700.0 True False 24582627.872141033 17312134.278302822 38101433.62645449 1.0 0.7042426207786473 1.549933303494946 24.551135811633216 -6.812224380361574 1.4052007211114415 0.8392354143494818 1.565488147029801 0.8655510269056408 0.12848625389226287 0.20378026506409655 0.7926343138532632 0.07188890284958172 0.16612957442909196 1.540904131623004e-07 6.812224380361574 0.7262527326803192 GDNSSVSSLCISPDGK(ub)MLLSAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDNSSVSSLCISPDGKMLLSAGR 23 1 Q15061;C9JEE7 Q15061 WDR43 WD repeat-containing protein 43 1 65966400.0 21891000.0 5456400.0 38619000.0 True False 18203336.435732234 5427005.290189404 46694054.345918946 1.0 0.29813245002363775 2.5651371390500075 24.117699566181432 -6.823554923926731 1.3564120892518245 0.6229932237412174 2.6185081124039917 0.8923632750801996 0.31089031309867554 0.18890510625245488 0.6819378274289257 0.18006423369193067 0.4146807371861557 1.501222538615207e-07 6.823554923926731 1.9955148886627745 up GDNSSVSSLCISPDGK(ub)MLLSAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GDNSSVSSLCISPDGKMLLSAGR 23 1 Q15061;C9JEE7 Q15061 WDR43 WD repeat-containing protein 43 1 167117900.0 48833900.0 31142000.0 87142000.0 True False 63216446.2100807 29408920.323981863 71283050.15242691 1.0 0.4652099585960626 1.127602932875083 25.913796598865503 -6.691879898748429 1.859952130179068 0.6653108571501413 1.1253540404840847 0.37917263828493053 0.2260930169001788 0.4126228547899214 2.769044044497025 0.09719761923048925 0.2524910840916985 2.0329191234761675e-07 6.691879898748429 0.46004318333394345 GDPEMEQK(ub)MNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDPEMEQKMNR 11 1 O15067;J3KT98 O15067 PFAS Phosphoribosylformylglycinamidine synthase 1 2277480.0 362050.0 403530.0 1511900.0 True False 350556.92092615017 564661.6333811497 1115888.0339722263 1.0 1.6107559134458047 3.1831864309628166 18.419289192197752 -6.95482880304936 0.5030481572126966 0.9693241827131462 3.892790893982165 0.9995277592687156 0.01998508246670465 0.08160276102015734 0.028371707689070998 0.02330514999729464 0.1297266018330156 1.1096121332236107e-07 6.95482880304936 2.9234667112690187 GDSHK(ub)LDFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDSHKLDFR 9 1 J3KNZ9;Q9HAH7;Q9HAH7-1 J3KNZ9 FBRS Probable fibrosin-1 1 10252200.0 3610600.0 4454200.0 2187400.0 True False 4733531.565100138 3789650.722335611 1961068.8310224146 1.0 0.800596905337303 0.41429296584418746 22.174485511952415 -6.960663115463847 0.42598708464031904 1.0160139214132837 0.18415955591150127 0.9997940028760952 0.003489658559124286 0.07946511692215404 0.020262491396885542 0.00501922274638473 0.032106201420756465 1.0948052832475564e-07 6.960663115463847 -0.8318543655017825 down GDSHK(ub)LDFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDSHKLDFR 9 1 J3KNZ9;Q9HAH7;Q9HAH7-1 J3KNZ9 FBRS Probable fibrosin-1 1 12306100.0 3262800.0 4727700.0 4315600.0 True False 3159224.1999664246 6615495.264629794 3185214.894775147 1.0 2.094025256168936 1.0082269231822796 21.591138893462546 -6.644481967130932 2.0287163198055898 1.7130124080499245 1.0128156557271688 0.1718021378367549 0.46758592194912474 0.5221889328963014 4.113022733559533 0.1873592292570572 0.517673491639434 2.2673472204705442e-07 6.644481967130932 -0.7001967523227557 GDSHK(ub)LDFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDSHKLDFR 9 1 J3KNZ9;Q9HAH7;Q9HAH7-1 J3KNZ9 FBRS Probable fibrosin-1 1 12987300.0 3262800.0 6058600.0 3665900.0 True False 2713162.766548223 6025961.119262061 4432422.7407935 1.0 2.2210098094956874 1.6336737314262122 21.371544168896822 -9.965224488034396 5.387182523441703 0.999997529895966 1.927341770463742 0.7687261083522348 0.23977894980941133 7.113346957258365e-06 1.3662400081680359e-06 0.232165588872691 0.07738832328049576 1.0833667739441236e-10 9.965224488034396 0.9273442405677761 GDSVIVVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDSVIVVLR 9 0 P62316;P62316-2;K7EJB5 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 33385300.0 12077000.0 11541000.0 9767300.0 False True 15833063.953834374 9819127.786465641 8756673.490557378 1.0 0.6201659903033293 0.5530624720578312 23.916437131516705 -13.999999999999998 0.24383980258621446 3.5617339631035505 0.5244547746282716 0.9995315017606557 0.004259438536122394 13.762137077413023 0.15627231032800162 17.20539679209353 0.03206557865445917 1.0000000000000041e-14 13.999999999999998 -3.037279188475279 GDSVIVVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDSVIVVLR 9 0 P62316;P62316-2;K7EJB5 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 29983100.0 11515000.0 7850100.0 10618000.0 False True 11149462.627992317 10984685.867730696 7836827.266827896 1.0 0.9852211029572021 0.7028883389547782 23.410470842284198 -6.917740675853858 0.8413113161964876 1.0067510850055934 0.6596440930013476 0.9935300004560765 0.010996411023119067 0.09951951962732959 0.11263667130345513 0.009362883394189505 0.02746822996190006 1.2085352553321693e-07 6.917740675853858 -0.3471069920042458 GDSVIVVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDSVIVVLR 9 0 P62316;P62316-2;K7EJB5 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 79794000.0 19394000.0 41941000.0 18459000.0 False True 29422115.89131899 34456300.86347129 14810570.559132889 1.0 1.1711020713380318 0.5033822385120423 24.81039766594184 -6.838719464308119 1.2882989359434112 1.0910433311121135 0.4819669046184162 0.9222372984589357 0.07896948088997444 0.17029736466869627 0.5495890282484032 0.048074913127410294 0.11072205373639668 1.4497080006257178e-07 6.838719464308119 -0.6090764264936973 GDSVIVVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDSVIVVLR 9 0 P62316;P62316-2;K7EJB5 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 36959000.0 12077000.0 13584000.0 11298000.0 False True 16542193.268653287 12983813.963719085 8629645.089613901 1.0 0.7848907187127857 0.5216747833533472 23.979647193039597 -6.968420040298796 0.2934798799850453 1.0493362670091564 0.2490572254928413 0.9999673019218821 0.0011184946024989048 0.07681877032537043 0.010855512497778419 0.004514415700453398 0.0237751306247428 1.075424582905387e-07 6.968420040298796 -0.8002790415163151 GDSVIVVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDSVIVVLR 9 0 P62316;P62316-2;K7EJB5 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 23250100.0 11515000.0 7126000.0 4609100.0 False True 9575232.700993855 7087610.823599745 5572841.499929434 1.0 0.7402024624283117 0.5820058555183734 23.190876117718474 -10.356085062543698 0.0802506605585476 1.8875369733746636 6.645353811928612e-05 0.9999623329653025 0.0010575569100106416 2.1750296091991363 0.041908877216853796 0.6993798237531457 0.3254550323747329 4.404685832309331e-11 10.356085062543698 -1.8874705198365445 GDSVIVVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDSVIVVLR 9 0 P62316;P62316-2;K7EJB5 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 61076000.0 19394000.0 28372000.0 13310000.0 False True 25105915.31289341 26793073.25900759 10887716.572132854 1.0 1.0672016106597684 0.433671365351151 24.581523988034288 -6.880676210652983 1.0760630599969259 1.0420300484936658 0.3881948181434964 0.9742249799192857 0.04561706764613339 0.12703084787084942 0.26870395171335515 0.03263681645356107 0.07905868511876912 1.316205767008903e-07 6.880676210652983 -0.6538352303501693 down GDTHPLTLDEILDETQHLDIGLKQK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDTHPLTLDEILDETQHLDIGLKQK 25 1 E5RIW4;E5RH41;P29084 E5RIW4 GTF2E2 Transcription initiation factor IIE subunit beta 1 18381400.0 2322400.0 12172000.0 3887000.0 True False 1931178.4997644937 12106427.020047164 4699753.728542599 1.0 6.268932168374667 2.433619538077776 20.881050088777567 -6.564263457350875 2.3284241145598195 4.621104386405921 2.4402629189479392 0.0 2.2980119000916552 0.7479118078379792 7.60362661963654 0.8369817177589349 2.58230808656286 2.72732279694921e-07 6.564263457350875 -2.180841467457982 GDTNIKPILQVINIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDTNIKPILQVINIR 15 1 P27694;I3L524;I3L2M5 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 0 3958300.0 1359400.0 0.0 2598900.0 False True 1782186.5644483278 0.0 2329990.7584091397 1.0 0.0 1.3073775803771608 20.765216939582395 -6.702296701950222 1.8225380049004571 0.3804373153894391 1.30367825447045 0.42851116012354595 0.42193904786658215 0.3907807522764567 2.5250957519137747 0.18457828473985002 0.47337036765348667 1.9847385174635358e-07 6.702296701950222 0.9232409390810108 GDTNIKPILQVINIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDTNIKPILQVINIR 15 1 P27694;I3L524;I3L2M5 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 0 7077300.0 1359400.0 2070400.0 3647500.0 False True 1862006.9164036834 1978922.8821027663 2786035.622620528 1.0 1.0627902961418085 1.4962541750390121 20.828427001105286 -6.9329443209026875 0.7222106042431563 0.9940745113881616 1.5923051643204185 0.9970860396100487 0.01190989729244436 0.09113734751870492 0.07039890177633305 0.011047214646245055 0.038605593533595765 1.166959218480432e-07 6.9329443209026875 0.5982306529322569 GDTPGHATPGHGGATSSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDTPGHATPGHGGATSSAR 19 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 6360370.0 1082000.0 713570.0 4564800.0 False True 1047652.5022568564 998502.2222183915 3369141.938935391 1.0 0.9530853217716894 3.215896427181317 19.998728835430807 -6.902165494485939 0.9474611425771136 0.9114281523544521 3.464157841606741 0.9876135878246676 0.11750617314163034 0.10982940793955989 0.1685601278190809 0.09262321960101295 0.24372077182687205 1.2526637375019467e-07 6.902165494485939 2.552729689252289 up GDTVLLK(ub)GK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDTVLLKGK 9 1 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 1 4959600.0 1116600.0 1830300.0 2012700.0 True False 1463873.4131697817 1557226.374453519 1804445.1111816824 1.0 1.0637711980037923 1.2326510577676575 20.481359372885905 -6.9542158929675715 0.5104668376941834 0.9969038005707647 1.3069333694146281 0.9994919431255777 0.002212469338070788 0.081835732903829 0.029288373368917847 0.002546282692028897 0.01393849639299358 1.1111792095212834e-07 6.9542158929675715 0.31002956884386346 GDTVLLK(ub)GK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDTVLLKGK 9 1 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 1 12208000.0 2514500.0 4119600.0 5573900.0 True False 2434678.5738677117 5764577.7634302005 4113928.3765842984 1.0 2.3676956068466306 1.6897213540795832 21.215299889682775 -10.272196621005605 6.808925804055414 0.9999886045072817 2.028708480463107 0.7542820862906536 0.2767818296706622 4.788056701842751e-05 5.117286862956186e-06 0.26799581269407435 0.08933095140394101 5.343223973249762e-11 10.272196621005605 1.0287198759558254 GDTVLLK(ub)GK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDTVLLKGK 9 1 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 1 17012300.0 4356900.0 5704000.0 6951400.0 True False 6609735.832055666 4686076.634444583 5577452.743093141 1.0 0.7089657973497537 0.8438238508782463 22.65616118275169 -10.056468521965664 4.574164549645222 1.0000105355434517 0.7763948241025266 0.7856666867397019 0.05505556984430379 76316516.98446968 1.8890231018016383 8684.771450871785 0.018846985944632976 8.780747283950909e-11 10.056468521965664 -0.22361571144092507 GDTVLLK(ub)GK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDTVLLKGK 9 1 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 1 4867000.0 1116600.0 1862700.0 1887700.0 True False 1529437.1949803967 1780399.7548748187 1441864.1384018555 1.0 1.1640881761723068 0.9427416458381191 20.544569434408796 -6.708130174586161 1.8016271923240477 1.1010672198389768 0.943283901991192 0.456353674626248 0.06916611049350826 0.3788330053068519 2.3957388203390755 0.03056311422668466 0.07782830626281974 1.958257621185971e-07 6.708130174586161 -0.15778331784778477 GDTVLLK(ub)GK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDTVLLKGK 9 1 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 1 10018800.0 2514500.0 5384500.0 2119800.0 True False 2090918.161237435 5355492.629760428 2563040.379152203 1.0 2.5613114511334927 1.2257966029791234 20.99570516511705 -6.608130715034538 2.1606655358779014 2.044437883722324 1.2305024502039368 0.044562120800028415 0.6734567311505234 0.6178698871134891 5.463310663348724 0.2576390565044294 0.7478815844218185 2.465297214262896e-07 6.608130715034538 -0.8139354335183873 GDTVLLK(ub)GK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDTVLLKGK 9 1 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 1 12254400.0 4356900.0 4950000.0 2947500.0 True False 5640092.937338619 4674528.1486002905 2411085.2439039545 1.0 0.8288033903934308 0.4274903393775758 22.427287504844138 -6.956825898653272 0.4780752269605944 1.0098093114007867 0.22980702929871963 0.9996337500326795 0.004591828172023244 0.08085511599584853 0.025473678232927458 0.005636491283813845 0.03310737395164593 1.1045213151629516e-07 6.956825898653272 -0.780002282102067 down GDVAEGDLIEHFSQFGTVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDVAEGDLIEHFSQFGTVEK 20 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 11147400.0 2529600.0 1975200.0 6642600.0 False True 2449299.232633037 2763907.6605319274 4902703.786271522 1.0 1.1284483429820378 2.0016761206433054 21.223937609075 -6.933252918284926 0.7195912438733528 0.9881900141758077 2.196758280017862 0.9971398379020493 0.02379985445690913 0.09098351300602632 0.06966142454322884 0.02211874556608352 0.07764717485351699 1.1661303047834889e-07 6.933252918284926 1.2085682658420547 up GDVDVSLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDVDVSLPK 9 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 8874750.0 2961100.0 841550.0 5072100.0 False True 2867101.501324195 1177585.303625275 3743564.8502616175 1.0 0.4107232698533335 1.3056966586403098 21.45116154919559 -6.729143616082923 1.7266881311197702 0.6450323026417212 1.3050484691166508 0.5551563379485238 0.24773444560051008 0.33783915476040066 1.9729696328862532 0.11372403068053402 0.28243634155325636 1.865762603035254e-07 6.729143616082923 0.6600161664749297 GDVGLGLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDVGLGLVK 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 8453360.0 2925100.0 830360.0 4697900.0 False True 2832244.3016187893 1161927.0782701944 3467379.05602098 1.0 0.4102495952083253 1.2242514016319759 21.433514283026394 -6.71237804945068 1.7867792125247104 0.6383134931789072 1.2224704621977516 0.4763350527123723 0.2484279090228023 0.37033185277566566 2.3061676875253445 0.11058473563588285 0.2801246633486322 1.9391970889912566e-07 6.71237804945068 0.5841569690188444 GDVGLGLVK(ub)EGLVMVEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDVGLGLVKEGLVMVEVR 18 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 38104100.0 3667700.0 5820400.0 28616000.0 True False 4747909.951175577 5496489.623457195 23408181.62495522 1.0 1.1576650947426395 4.930207578844114 22.17886114242017 -6.9156824746357755 0.8561205680031876 0.903120950646341 5.4820275481113505 0.9928954863193025 0.1531261952915104 0.10077941118647882 0.11926522169984737 0.12900166195754148 0.37182488397705116 1.214276318835956e-07 6.9156824746357755 4.57890659746501 up GDVGSADIQDLEK(ub)WLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDVGSADIQDLEKWLAK 17 1 Q9Y5M8;H7C4H2 Q9Y5M8 SRPRB Signal recognition particle receptor subunit beta 1 9757600.0 3860700.0 3334500.0 2562400.0 True False 3738144.1917403345 4665983.239187787 1891230.569647749 1.0 1.2482084691910953 0.5059276669494297 21.833890788673855 -6.8165234371218935 1.386706317262268 1.1342708942163406 0.49088037675595303 0.8762420195250419 0.10853720812392789 0.19802977324316057 0.7491509473184282 0.061518997458790456 0.14194929881403798 1.525726055303038e-07 6.8165234371218935 -0.6433905174603876 GDVLHMHYTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDVLHMHYTGK 11 0 A0A494C1N0;P26885 A0A494C1N0 FKBP2 Peptidyl-prolyl cis-trans isomerase FKBP2 0 6206100.0 2626800.0 913800.0 2665500.0 False True 3443760.2379673864 777464.6019645019 2389699.629281454 1.0 0.22576037477666724 0.693921604336755 21.7155532720077 -10.441508472924589 7.048776253209628 1.0000624942141614 0.45984098956746483 0.6396357857069065 0.19112602162936596 0.00018772618108093766 1.4874165343586221e-05 0.1850781940939152 0.06168565823311775 3.618191317062373e-11 10.441508472924589 -0.5402215046466965 GDVLTIVAVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDVLTIVAVTK 11 0 P41240;H3BUM9;H3BN15 P41240 CSK Tyrosine-protein kinase CSK 0 7525000.0 2413800.0 3185100.0 1926100.0 False True 3164515.1752724485 2709895.4954225575 1726805.6484558252 1.0 0.8563382841699438 0.5456777903765799 21.593553055452382 -6.958489144237279 0.45622785659831716 1.009404447724483 0.38016720108197544 0.999709994393746 0.003228916766532307 0.08024529925508506 0.023159277055922783 0.0041927531306935086 0.025674965038632147 1.1002993483837586e-07 6.958489144237279 -0.6292372466425076 GDVLTIVAVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDVLTIVAVTK 11 0 P41240;H3BUM9;H3BN15 P41240 CSK Tyrosine-protein kinase CSK 0 19992200.0 3013600.0 11153000.0 5825600.0 False True 4571851.523671181 9162660.011213265 4674167.606548818 1.0 2.0041464522136714 1.0223795725534581 22.124347120395914 -6.640937650007679 2.0408820479755896 1.6561930723479121 1.0264621136076202 0.1582074218606423 0.4295456233487695 0.5310705218774012 4.228724105144745 0.17131934444135852 0.4757045232836869 2.2859269615811275e-07 6.640937650007679 -0.629730958740292 GDVLTIVAVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDVLTIVAVTK 11 0 P41240;H3BUM9;H3BN15 P41240 CSK Tyrosine-protein kinase CSK 0 6658200.0 2413800.0 2221700.0 2022700.0 False True 3306247.090492279 2123537.9478205703 1544979.9188141301 1.0 0.642280473811892 0.4672911239020834 21.656763116975274 -13.999999998262158 0.09383116903074724 2.8034501109060175 0.056191714996287 0.9998241486119386 0.002939952694905522 12.130215903520172 0.08991738392627983 4.309731924321148 0.36817541963676753 1.0000000040015288e-14 13.999999998262158 -2.7472583959097303 GDVPTK(ub)RPPVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDVPTKRPPVLR 12 2 P62424;Q5T8U3;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 28189400.0 7462100.0 6208300.0 14519000.0 True False 9782885.3630792 5282045.839763866 13016713.156082312 1.0 0.5399271936374119 1.3305597145406243 23.22182860557246 -6.748928871519761 1.653706423987263 0.7291382242831631 1.3320184972020417 0.644477558207832 0.19331528783133134 0.3018728150393418 1.6239097755971972 0.09235668159280673 0.22447880874853882 1.7826707082407815e-07 6.748928871519761 0.6028802729188786 GDVPTK(ub)RPPVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDVPTKRPPVLR 12 2 P62424;Q5T8U3;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 30257600.0 7462100.0 5588500.0 17207000.0 True False 10221040.02567009 5341581.591301821 13143060.989288937 1.0 0.5226064644973961 1.2858829391412425 23.28503866709535 -6.737610548927487 1.6956085174611297 0.7151684319282113 1.286087585366003 0.594112830721012 0.2005942629459598 0.3221488162402464 1.8176973039055733 0.09362816577937952 0.23034595153650578 1.8297402897241373e-07 6.737610548927487 0.5709191534377916 GDVPTK(ub)RPPVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDVPTKRPPVLR 12 2 P62424;Q5T8U3;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 42491100.0 8737100.0 15429000.0 18325000.0 True False 7265285.769157916 15345880.914583288 22156672.77477314 1.0 2.1122198633574127 3.0496629422109036 22.79258811455169 -6.973101314467814 0.16835605566035977 0.1531840475720056 5.0337644927735585 0.9999975698277341 0.0013060108244810974 0.0753086030876289 0.005242233012538045 0.04010970743341106 0.10921450746688767 1.0638947983793906e-07 6.973101314467814 4.880580445201553 GDVTAQIALQPALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDVTAQIALQPALK 14 0 P04179-4;P04179;F5H3C5;F5H4R2;F5GYZ5;P04179-3 P04179-4 SOD2 Superoxide dismutase [Mn], mitochondrial 0 11154500.0 2247600.0 4909800.0 3997100.0 False True 2946625.365789361 4177276.978250507 3583518.4348906004 1.0 1.4176478037381828 1.2161432113140804 21.4906322170698 -10.128156226232619 4.3346471848242425 0.9999509493527792 1.3168955075142454 0.7673132323617506 0.08226390548178518 57422421.16493884 3.274729597717375 30201.488799358674 0.028161122922331226 7.444641239755977e-11 10.128156226232619 0.31694455816146627 GDVTAQIALQPALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDVTAQIALQPALK 14 0 P04179-4;P04179;F5H3C5;F5H4R2;F5GYZ5;P04179-3 P04179-4 SOD2 Superoxide dismutase [Mn], mitochondrial 0 17118700.0 3933300.0 2891400.0 10294000.0 False True 3808439.5444795704 4045951.098451808 7597692.58661956 1.0 1.0623645330845586 1.9949621092535412 21.860768563738436 -6.920462655311748 0.8212894356410859 0.9797642331291558 2.146963423722511 0.9943084751611749 0.034329442288267224 0.09790021713973124 0.10420959056016803 0.029651040927376762 0.08921543308975809 1.2009843404043927e-07 6.920462655311748 1.167199190593355 GDVTAQIALQPALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDVTAQIALQPALK 14 0 P04179-4;P04179;F5H3C5;F5H4R2;F5GYZ5;P04179-3 P04179-4 SOD2 Superoxide dismutase [Mn], mitochondrial 0 76745000.0 10098000.0 43649000.0 22998000.0 False True 15319404.262686335 35859494.91880642 18452435.219618533 1.0 2.3407891262553755 1.204513889914333 23.868856859386987 -6.605769891370716 2.1699436518296165 1.898345071717551 1.2084744181478952 0.03728831970502833 0.5786887158488343 0.6244018099583011 5.565301784881635 0.22073707868757042 0.642718317256799 2.4787350543905595e-07 6.605769891370716 -0.6898706535696557 GDVTAQIALQPALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDVTAQIALQPALK 14 0 P04179-4;P04179;F5H3C5;F5H4R2;F5GYZ5;P04179-3 P04179-4 SOD2 Superoxide dismutase [Mn], mitochondrial 0 11577900.0 2247600.0 4015300.0 5315000.0 False True 3078598.4591061603 3837890.769178531 4059706.4658610267 1.0 1.2466357078255745 1.3186865776057464 21.55384227859269 -13.349170722104141 0.18034641585928976 1.312327510438166e-06 1.377349410881327 0.9994828580219024 0.0031031023607121892 9.482363517516458 0.13006671895506505 3.3768979085997692 0.05358514550134282 4.475373416919232e-14 13.349170722104141 1.3773480985538165 GDVTAQIALQPALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDVTAQIALQPALK 14 0 P04179-4;P04179;F5H3C5;F5H4R2;F5GYZ5;P04179-3 P04179-4 SOD2 Superoxide dismutase [Mn], mitochondrial 0 10452900.0 3933300.0 4531100.0 1988500.0 False True 3270713.2247346235 4506690.064947073 2404286.156214809 1.0 1.3778921462344758 0.7350953724809934 21.641173839172712 -6.747386410804841 1.6594670077943983 1.2229020338707575 0.7340651625817786 0.6376495289893396 0.15877693919194688 0.3046361126832327 1.64972554575992 0.07560850799828917 0.184067193261461 1.7890133822028315e-07 6.747386410804841 -0.4888368712889789 GDVTAQIALQPALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDVTAQIALQPALK 14 0 P04179-4;P04179;F5H3C5;F5H4R2;F5GYZ5;P04179-3 P04179-4 SOD2 Superoxide dismutase [Mn], mitochondrial 0 43199000.0 10098000.0 19291000.0 13810000.0 False True 13072060.06133842 18217438.89184813 11296721.702566093 1.0 1.3936165230549655 0.8641883260601732 23.639983181479437 -6.707623256556678 1.803577364796976 1.2425751943507735 0.8655140201654882 0.45379271761426376 0.16593154307478675 0.3799049434252756 2.4074307907774193 0.07325339291909613 0.18664332826503785 1.9605446768545293e-07 6.707623256556678 -0.3770611741852853 GDVTITNDGATILK(ub)QMQVLHPAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDVTITNDGATILKQMQVLHPAAR 24 1 P50991 P50991 CCT4 T-complex protein 1 subunit delta 1 9415100.0 2844800.0 4004700.0 2565600.0 True False 2365577.246008456 3983125.8862292855 3102055.0980058913 1.0 1.6837860158446278 1.3113311362967017 21.173760840980677 -10.151338396294289 4.478807443160256 0.9999235276475803 1.497558576084496 0.7040954196449312 0.1520540679027279 106380770.80350183 13.419109292414213 86316.00824982031 0.05205215183636849 7.05767415685583e-11 10.151338396294289 0.49763504843691575 GDVVIVLTGWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDVVIVLTGWR 11 0 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 1243170.0 871200.0 371970.0 0.0 False True 724441.4007039389 369966.1237797357 0.0 1.0 0.5106915803269112 0.0 19.466509470867813 -7.895997004413895 0.5995855278952199 1.0089357456659742 3.1885746336571556e-18 0.9887466366099776 0.043311042381911316 0.11333111678027287 0.1601145702309145 0.044387130262797427 0.07729550991769807 1.2705828691404347e-08 7.895997004413895 -1.0089357456659742 down GDVVIVLTGWRPGSGFTNTMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 GDVVIVLTGWRPGSGFTNTMR 21 1 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 34631100.0 12203000.0 11672700.0 10755400.0 False True 15998251.174020104 9931178.659828229 9642534.381081872 1.0 0.620766517027541 0.6027242775598239 23.931410871795183 GDVVIVLTGWRPGSGFTNTMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 GDVVIVLTGWRPGSGFTNTMR 21 1 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 236146500.0 95787400.0 57537900.0 82821200.0 False True 92746681.41837192 80513083.52618457 61127843.13725813 1.0 0.8680966509518256 0.6590838852930591 26.46679232560092 -6.964329865695851 0.3693798602280285 1.0161866648692532 0.5037256185751635 0.9998986470349538 0.0014130524524990796 0.07818919444345618 0.015666772278150207 0.002757568776427473 0.017757242625742863 1.0856007490374508e-07 6.964329865695851 -0.5124610462940897 GDVVIVLTGWRPGSGFTNTMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GDVVIVLTGWRPGSGFTNTMR 21 1 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 672560000.0 202404000.0 225921000.0 244235000.0 False True 307061665.7144746 185603632.4211703 195961845.19799656 1.0 0.6044506792774201 0.6381840101792917 28.193953173282885 -9.944815191244965 5.7672585422823515 1.000000310993817 0.6213173452792724 0.9940836765677173 0.01377157467328051 5.5064609271205777e-08 1.0060127752162828e-08 0.013334280767812528 0.004444756613251913 1.1354939085534571e-10 9.944815191244965 -0.3786829657145445 GDVVIVLTGWRPGSGFTNTMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GDVVIVLTGWRPGSGFTNTMR 21 1 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 40254570.0 12203000.0 6960270.0 21091300.0 False True 16714778.87367525 6652742.256865064 16109969.328958541 1.0 0.3980155709593457 0.963815881185886 23.994620933318075 -10.73881516276321 10.005040038237729 1.000777572059292 0.6809157260726167 0.29778040627105284 0.23098700939390843 0.0040148278348175435 0.00010480803768344933 0.22412533095842155 0.07455073671440528 1.8246721238644136e-11 10.73881516276321 -0.3198618459866752 GDVVIVLTGWRPGSGFTNTMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GDVVIVLTGWRPGSGFTNTMR 21 1 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 199219000.0 95787400.0 39404600.0 64027000.0 False True 79651467.20131828 39192319.59859929 77414749.6726003 1.0 0.4920476794173935 0.9719186901722137 26.247197601035197 -10.653433141061026 9.714234511967476 1.0001152206445691 0.7319831847948036 0.2937473137798182 0.19590651978382134 0.0004890730413620781 1.744825759836347e-05 0.18976595781361613 0.06322855737801615 2.2210935909281933e-11 10.653433141061026 -0.2681320358497655 GDVVIVLTGWRPGSGFTNTMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GDVVIVLTGWRPGSGFTNTMR 21 1 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 536522000.0 202404000.0 183859000.0 150259000.0 False True 262015967.97931683 173627085.0249498 122913403.78753664 1.0 0.6626584111036151 0.4691065385650055 27.965079495375335 -10.223244758740933 0.10825956483965166 1.82357578037915 5.911859899670485e-12 0.9998989996811279 0.002204639096563106 1.9272990615182057 0.053841401357098535 0.69140604193974 0.2645353880941736 5.980744385690607e-11 10.223244758740933 -1.823575780373238 GDVVPK(ub)DVNAAIATIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDVVPKDVNAAIATIK 16 1 P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 122872000.0 38194000.0 54362000.0 30316000.0 True False 50072703.87122211 46251401.501416296 27179191.131606273 1.0 0.9236849206379286 0.5427945573202161 25.57752102569033 -6.93984644096182 0.6610011780501897 1.004286921712701 0.4405465465993642 0.9981435667162375 0.008616528677949712 0.08783708470859329 0.0549315178141116 0.008377735058214361 0.03280479554151817 1.1485596605943092e-07 6.93984644096182 -0.5637403751133369 GDVVPK(ub)DVNAAIATIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDVVPKDVNAAIATIK 16 1 P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 150456000.0 58365000.0 46596000.0 45495000.0 True False 56512235.022385806 65202025.794929914 33578494.679255575 1.0 1.153768308209751 0.5941809710048516 25.752059912185366 -6.833445924004603 1.3124318874565692 1.0819877559675914 0.578033540198208 0.9125958079582245 0.06978596975033392 0.17659541614041455 0.5936685754896946 0.04173354915845661 0.0960443048447785 1.4674187905685795e-07 6.833445924004603 -0.5039542157693835 GDVVPK(ub)DVNAAIATIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDVVPKDVNAAIATIK 16 1 P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 555502000.0 104470000.0 93252000.0 357780000.0 True False 158488627.78004003 76610452.0187985 287064626.1794552 1.0 0.4833813825754303 1.811263244564529 27.23980408379198 -6.801205393162776 1.4510564094993388 0.7153942813841474 1.8301299392830628 0.8356479517110962 0.22156758740113108 0.21903988316259965 0.9104095940354461 0.12011873750892903 0.27914050412658553 1.5805003881668486e-07 6.801205393162776 1.1147356578989154 GDVVPK(ub)DVNAAIATIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDVVPKDVNAAIATIK 16 1 P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 126823000.0 38194000.0 48205000.0 40424000.0 True False 52315353.954040155 46075143.7073821 30876683.758413218 1.0 0.8807193342868295 0.5902030938286084 25.640731087213222 -6.956019011519145 0.48832048302141495 1.0064555726336621 0.4521827501261494 0.9995928618050453 0.0034725413682117423 0.08115512271372526 0.026628609719028907 0.00416779045031694 0.023961021018656537 1.1065753418729429e-07 6.956019011519145 -0.5542728225075128 GDVVPK(ub)DVNAAIATIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GDVVPKDVNAAIATIK 16 1 P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 126578000.0 58365000.0 45535000.0 22678000.0 True False 48533083.50790336 45289693.91701015 27419864.948775217 1.0 0.9331715737706004 0.5649726530215216 25.532465187619643 -6.937666103459329 0.680935432124111 1.0043472539516514 0.47214838971869666 0.9978418555819266 0.008885974478482796 0.08884791009519083 0.059581751340300484 0.008503851276462613 0.0320296901498877 1.154340402735424e-07 6.937666103459329 -0.5321988642329547 GDVVPK(ub)DVNAAIATIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDVVPKDVNAAIATIK 16 1 P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 352450000.0 104470000.0 0.0 247980000.0 True False 135238474.41156933 0.0 202850184.48966992 1.0 0.0 1.4999443418175424 27.01093040588443 -6.726963378247132 1.7339615590812474 0.39620089406608117 1.498632223545314 0.5453231579098374 0.4204848688019388 0.3419391341493464 2.0126024625381023 0.19227029515224817 0.47881676240035903 1.8751526230874083e-07 6.726963378247132 1.102431329479233 GDVVPK(ub)DVNAAIATIKTK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDVVPKDVNAAIATIKTK 18 2 P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 2 56267000.0 16425000.0 27159000.0 12683000.0 True False 15903597.365590433 38003730.33231396 9360941.818155803 1.0 2.38963106639886 0.5886053075268025 23.922849801701044 -6.700632742457447 1.8284199627500575 1.8623615964697682 0.5938627499090535 0.42066598793872545 0.5865121955936193 0.39420761946164956 2.56254813524818 0.25585421187491786 0.6575232582186213 1.992357447434698e-07 6.700632742457447 -1.2684988465607145 GDYDAFFEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDYDAFFEAR 10 0 O75368 O75368 SH3BGRL SH3 domain-binding glutamic acid-rich-like protein 0 5241700.0 1123000.0 1847800.0 2270900.0 False True 1472263.87514747 1572115.4426679846 2035929.0520109707 1.0 1.0678217873888354 1.3828560806105772 20.48960483939356 -6.94146075091778 0.6458343136711964 0.9965337276044334 1.471589457872426 0.9983490013209516 0.006777834303184752 0.08710656845335431 0.05162270321906489 0.006673152532273103 0.0269446711928875 1.1442982903601526e-07 6.94146075091778 0.47505573026799264 GDYLAVVLATQGHTQVLIHQLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GDYLAVVLATQGHTQVLIHQLSR 23 0 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 31088900.0 5817900.0 11950000.0 13321000.0 False True 8826179.645462755 9817429.134223843 10688098.511198286 1.0 1.1123078759529506 1.210954109311913 23.073357681127156 -6.972649769030475 0.18420990869480555 0.9278669398964343 1.398073922778145 0.9999963485483049 0.00016458166431062822 0.07545191093879672 0.0058372202611345425 0.003660886782667948 0.010932196044339385 1.0650015282324134e-07 6.972649769030475 0.4702069828817106 GDYPLEAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GDYPLEAVR 9 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 72441400.0 2722400.0 37379000.0 32340000.0 False True 3569092.7637591013 31802198.90220084 28993767.027185217 1.0 8.910443355556156 8.123567793359314 21.767125968070605 -10.43596770413954 6.647856059301779 0.9986620519328719 8.517005574457734 0.9918486593116866 0.3212406030746519 0.006368644202379104 0.0005403435657739712 0.3109638561312089 0.10367995881947958 3.664648254127163e-11 10.43596770413954 7.518343522524862 GDYPLEAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDYPLEAVR 9 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 64344800.0 25067000.0 6017800.0 33260000.0 False True 24271261.80598211 8420738.92241243 24548208.221387826 1.0 0.3469427749461703 1.0114104663210157 24.53274577698212 -10.940097917714814 11.803631397507663 1.0629801761478432 0.6791766206363885 0.2371246067125582 0.2712677990722504 0.1370589784426374 0.0006955576344072857 0.08007032943245486 0.08755130568076379 1.1478947835178876e-11 10.940097917714814 -0.38380355551145473 GDYPLEAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GDYPLEAVR 9 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 89921400.0 2722400.0 40865000.0 46334000.0 False True 3728944.8500937046 39059449.17751616 35390863.47868384 1.0 10.474665286759238 9.490851943759505 21.830336029593497 -10.484230325791133 6.758782127652623 0.9970662689139136 9.982758615259195 0.9910838448240173 0.40164011541518313 0.01772450952213019 0.0013525753377449233 0.38819940731137154 0.12962878984765186 3.2792133563522396e-11 10.484230325791133 8.985692346345282 GDYPLEAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GDYPLEAVR 9 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 7965700.0 2209100.0 3627700.0 2128900.0 False True 2859723.4978711344 3425815.3059954075 1741462.0443586537 1.0 1.197953336588551 0.6089616865599249 21.447444231175954 -6.81606875502714 1.3888859477575584 1.1071366456470582 0.5971643381988196 0.8750846858643944 0.08649361546106375 0.1986375705819974 0.7539611687003144 0.048951647742155914 0.11295610605668718 1.527324241828005e-07 6.81606875502714 -0.5099723074482385 GDYPQAMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GDYPQAMK 8 0 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 5021730.0 1233000.0 743530.0 3045200.0 False True 1193859.0899100774 1040425.4064577277 2247570.7659582174 1.0 0.8714809103108588 1.8826097526530594 20.18720113600683 -6.875000807903824 1.1073513088419946 0.9245837424097542 1.9477245506243182 0.9694219703030361 0.07859018821742547 0.1321480040312545 0.29986000873142904 0.05489642378875141 0.13121766526260847 1.3335189514593155e-07 6.875000807903824 1.0231408082145639 GEAHLAVNDFELAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEAHLAVNDFELAR 14 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 29313600.0 6402600.0 11754000.0 11157000.0 False True 8393870.602866596 10000349.016733153 10002580.665501079 1.0 1.191387083488984 1.1916529499614983 23.00090479260976 GEAHLAVNDFELAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEAHLAVNDFELAR 14 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 24338900.0 7832600.0 4882300.0 11624000.0 False True 7583958.400348479 6831827.850858155 8579325.687474802 1.0 0.9008261240652686 1.1312464065046277 22.85451962008783 -6.789747694859896 1.4973400839936362 0.9445522597983039 1.1336795376229392 0.800481531671799 0.042153580945595036 0.23574265582757736 1.0441577901119112 0.02215932775277313 0.0518899786096888 1.6227525682502371e-07 6.789747694859896 0.18912727782463523 GEAHLAVNDFELAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEAHLAVNDFELAR 14 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 40164700.0 3301700.0 31503000.0 5360000.0 False True 5008920.286602444 25881043.515937567 4300593.650628541 1.0 5.166990495968285 0.8585869617712838 22.25606822163901 -6.6537699991325425 1.9948372100412401 3.6958875104645164 0.8766227506007289 0.20948618216084525 1.7768863857633486 0.4994229087439935 3.813490349238202 0.7212928931358789 1.9688845265228894 2.21937148013953e-07 6.6537699991325425 -2.8192647598637874 GEAHLAVNDFELAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEAHLAVNDFELAR 14 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 23386900.0 6402600.0 8950400.0 8033900.0 False True 8769814.243759166 8554941.73298521 6136458.28336423 1.0 0.9754986246228801 0.699725001328403 23.06411485413265 -6.924338777778317 0.7918794662694603 1.0051870472887856 0.6504904240321913 0.9953037914814195 0.009329789162740175 0.09568569786353426 0.09287389061259409 0.008229169649598207 0.025772942107914077 1.1903131245744767e-07 6.924338777778317 -0.35469662325659435 GEAHLAVNDFELAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEAHLAVNDFELAR 14 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 14906000.0 7832600.0 3892300.0 3181100.0 False True 6513153.943013857 3871331.4073389396 3846253.3022554354 1.0 0.5943865969099977 0.5905362188438684 22.634924895522108 GEAHLAVNDFELAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEAHLAVNDFELAR 14 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 13193000.0 3301700.0 5481100.0 4410200.0 False True 4274115.736236984 5176071.966725873 3607588.852473358 1.0 1.2110275636295682 0.8440550221622101 22.027194543731458 -6.7507377442159235 1.6469175767132291 1.1239732048267816 0.843275005905608 0.6522444273710577 0.08867877327079011 0.2987475367141835 1.59446302207669 0.04252986527404164 0.10317913659266603 1.7752611776028634e-07 6.7507377442159235 -0.28069819892117365 GEALASISHVAHVTITTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEALASISHVAHVTITTK 18 0 A0A669KBB4;A0A669KBK2;H0Y818;A0A669KAW3;P40692;A0A669KB03 A0A669KBB4 MLH1 DNA mismatch repair protein Mlh1 0 15642900.0 3726400.0 7960500.0 3956000.0 False True 4823898.258325566 7517491.177158111 3236048.5919877975 1.0 1.5583851015480423 0.6708368250517518 22.201768048751838 -6.73665915440672 1.69909752526087 1.3335174349433823 0.6707029465554035 0.5897940733660001 0.23463477107142833 0.3238869989746958 1.8346485690104153 0.10930928645960153 0.2692075721454169 1.8337530347936252e-07 6.73665915440672 -0.6628144883879787 GEALK(ub)FHKPGENYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEALKFHKPGENYK 14 2 P47897;P47897-2;A0A1B0GVU9;B4DDN1;A0A0U1RQT0;C9J165;A0A0U1RR66;A0A0U1RQJ6 P47897 QARS Glutamine--tRNA ligase 1 22161520.0 1996200.0 2374020.0 17791300.0 True False 2584120.25098473 2241903.7000687 14553465.954153815 1.0 0.867569417179552 5.6318841774518535 21.301241776144995 -6.900508430347844 0.9580686893553236 0.8046712412204761 6.137138463327293 0.9868169834943482 0.2543622827568191 0.11103130987825684 0.17532554617939342 0.1989348122737649 0.5189153647427568 1.257452444975324e-07 6.900508430347844 5.332467222106817 up GEALSALDSK(ub)ANNLSSLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEALSALDSKANNLSSLSK 19 1 O75396 O75396 SEC22B Vesicle-trafficking protein SEC22b 1 11506200.0 4763000.0 4103900.0 2639300.0 True False 6524009.8152351985 3922576.1282175127 2015951.6980897489 1.0 0.6012523339645066 0.3090050069179841 22.63732752187987 -7.973570600136618 0.2279526719556701 1.2036207279999656 3.730799405006807e-17 0.9997421697415936 0.0045475609498403175 0.10529495568350711 0.039789344041584754 0.06936167027328613 0.09752843112107144 1.062745806275025e-08 7.973570600136618 -1.2036207279999656 down GEANIFTK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEANIFTKQR 10 1 Q9BVS4;H0Y8R4 Q9BVS4 RIOK2 Serine/threonine-protein kinase RIO2 1 3656820.0 526580.0 950440.0 2179800.0 True False 690351.4794079735 808638.0567861036 1954255.206118068 1.0 1.1713425420331822 2.8308119333560113 19.3969715442877 -6.926722460966446 0.7732127330282096 0.9714625303629005 3.1447093913629454 0.9958541106856891 0.05316151260316155 0.09437571657257401 0.08627923958725998 0.047519829322977256 0.1529485273046015 1.1837978286233082e-07 6.926722460966446 2.173246861000045 up GEANIFTK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEANIFTKQR 10 1 Q9BVS4;H0Y8R4 Q9BVS4 RIOK2 Serine/threonine-protein kinase RIO2 1 6251200.0 1221700.0 1107900.0 3921600.0 True False 1182917.8022247702 1550290.2476221758 2894415.314521781 1.0 1.3105646433813665 2.44684398956387 20.173918397488162 -6.9469251934831835 0.5916380838935411 0.9869287965729845 2.827817010913736 0.9989373687276879 0.020273008873679204 0.08474442595045117 0.0412568962816046 0.020982447210709812 0.09523897361212956 1.1299905369392786e-07 6.9469251934831835 1.8408882143407517 up GEANIFTK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEANIFTKQR 10 1 Q9BVS4;H0Y8R4 Q9BVS4 RIOK2 Serine/threonine-protein kinase RIO2 1 3001460.0 526580.0 883080.0 1591800.0 True False 721270.8562894292 844062.6056449527 1215849.6241500615 1.0 1.1702436030581138 1.6857046330763839 19.460181605810593 -6.951243204086793 0.5450244939864404 0.9926519102740791 1.887306201356708 0.9992952676902209 0.007739013583090137 0.082990345597621 0.033925847157379285 0.008454491931482571 0.04272326193646458 1.118811175867876e-07 6.951243204086793 0.8946542910826288 GEANIFTK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEANIFTKQR 10 1 Q9BVS4;H0Y8R4 Q9BVS4 RIOK2 Serine/threonine-protein kinase RIO2 1 5223400.0 1221700.0 2129700.0 1872000.0 True False 1015897.6804866873 2118226.8833876476 2263426.54484995 1.0 2.0850789642248873 2.2280064108086233 19.95432367292244 -10.759737061791366 0.38975938040320074 9.160791657200524e-17 2.242309739948803 0.9993910844143223 0.013530288344741426 2.3767068103924625 0.1886839444871521 2.267710496598868 0.03751598429964212 1.7388532772754862e-11 10.759737061791366 2.242309739948803 GEASNPDFGK(ub)TIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEASNPDFGKTIR 13 1 Q96BD0;E1P5H9;Q96BD0-3;Q96BD0-4 Q96BD0 SLCO4A1 Solute carrier organic anion transporter family member 4A1 1 21023700.0 1598100.0 1477200.0 17948400.0 True False 2095124.576022415 1256807.5180805 16091271.741209988 1.0 0.5998724526760808 7.6803412672287 20.998604598387903 -6.893516238017258 1.0013703421393767 0.6510024506731815 8.332944713040089 0.9830544314568218 0.4227522340648761 0.11633578260016002 0.20556328362624143 0.3201027719973765 0.8087988796775148 1.2778614301798565e-07 6.893516238017258 7.681942262366907 up GEASNPDFGK(ub)TIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEASNPDFGKTIR 13 1 Q96BD0;E1P5H9;Q96BD0-3;Q96BD0-4 Q96BD0 SLCO4A1 Solute carrier organic anion transporter family member 4A1 1 28362300.0 1598100.0 1123800.0 25640400.0 True False 2188960.7570286337 1074146.8000903628 19584665.600613937 1.0 0.49071085292019784 8.947015398850182 21.061814659910794 -6.892586101507882 1.0069914460265121 0.5733983407679206 9.712192724793521 0.982501477836144 0.5121807548370636 0.11706871828205132 0.20980736654523335 0.3861815422236001 0.9721357921409463 1.280601182437129e-07 6.892586101507882 9.138794384025601 up GEATVSFDDPPSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEATVSFDDPPSAK 14 0 Q92804-2;Q92804;A0A075B7D9;H3BPE7;P35637-2;P35637 Q92804-2;H3BPE7 TAF15;FUS TATA-binding protein-associated factor 2N;RNA-binding protein FUS 0 37587300.0 6056300.0 17848000.0 13683000.0 False True 7939867.949292621 15185147.970959103 12267214.416604055 1.0 1.9125189572342924 1.545014916488248 22.920683582928568 -10.193942545221757 4.754062292311306 0.9998927211573033 1.7287669368644247 0.8398243046194761 0.1500328963841864 0.0001706307252741425 2.8931110898614813e-05 0.14528990707262449 0.04842290908836669 6.398194744915293e-11 10.193942545221757 0.7288742157071214 GEATVSFDDPPSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEATVSFDDPPSAK 14 0 Q92804-2;Q92804;A0A075B7D9;H3BPE7;P35637-2;P35637 Q92804-2;H3BPE7 TAF15;FUS TATA-binding protein-associated factor 2N;RNA-binding protein FUS 0 30318600.0 8640700.0 2522900.0 19155000.0 False True 8366405.708180045 3530307.12674969 14137730.862317609 1.0 0.42196222008430934 1.6898213349246014 22.996176528935038 -6.782751939679308 1.5251343656472938 0.673864902321944 1.7007455145231327 0.7769917085203442 0.2447472442622805 0.24633336961644123 1.131891829152472 0.12637134220812798 0.2975066243016899 1.649104057819552e-07 6.782751939679308 1.0268806122011886 GEATVSFDDPPSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEATVSFDDPPSAK 14 0 Q92804-2;Q92804;A0A075B7D9;H3BPE7;P35637-2;P35637 Q92804-2;H3BPE7 TAF15;FUS TATA-binding protein-associated factor 2N;RNA-binding protein FUS 0 40720300.0 6056300.0 18124000.0 16540000.0 False True 8295477.775353544 17323221.751946714 12633592.65199272 1.0 2.088272938710684 1.5229493700203771 22.98389364445146 -10.042090534120842 5.324308284188674 0.9999936038275358 1.8056111543667894 0.7302887252864498 0.23079238048115702 1.7523218780805312e-05 3.1524233777092826e-06 0.22346553492363316 0.07448792050228724 9.076313033494641e-11 10.042090534120842 0.8056175505392537 GEATVSFDDPPSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEATVSFDDPPSAK 14 0 Q92804-2;Q92804;A0A075B7D9;H3BPE7;P35637-2;P35637 Q92804-2;H3BPE7 TAF15;FUS TATA-binding protein-associated factor 2N;RNA-binding protein FUS 0 17391400.0 8640700.0 5580500.0 3170200.0 False True 7185124.897913817 5550436.738857478 3833074.1626513423 1.0 0.7724899452296276 0.533473560600772 22.776581804369314 -6.9705023157227135 0.24589337448634524 1.0797894734310995 0.21920983678866954 0.9999860386706607 0.0007116947441992604 0.07614003441992574 0.00844491226812959 0.005482800311193645 0.023064427638400314 1.0702806760005621e-07 6.9705023157227135 -0.86057963664243 GEATVSFDDPPSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEATVSFDDPPSAK 14 0 Q92804-2;Q92804;A0A075B7D9;H3BPE7;P35637-2;P35637 Q92804-2;H3BPE7 TAF15;FUS TATA-binding protein-associated factor 2N;RNA-binding protein FUS 0 6805300.0 1585200.0 5220100.0 0.0 False True 2052072.648963525 4929596.846163309 0.0 1.0 2.40225259503029 0.0 20.968650376508954 -6.750329314030829 1.6608871155723257 1.825948938876209 1.5026333692375834e-10 0.6423215237224731 0.5892635044379081 0.30118586974504846 1.6369009723736552 0.280870267359656 0.6783835719793155 1.776931498854759e-07 6.750329314030829 -1.8259489387259455 GEDKDEGPVAEQVKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEDKDEGPVAEQVKK 15 2 Q8WWM7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7-3;H3BUF6 Q8WWM7 ATXN2L Ataxin-2-like protein 1 1769140.0 624420.0 565830.0 578890.0 True False 604598.1288902268 791768.8697644692 427261.3426722548 1.0 1.3095787630335618 0.7066865116776271 19.20561698855796 -6.767126276526353 1.5853773145881973 1.1782182369904186 0.7036523539681495 0.7194618000205182 0.13038053447587666 0.2711096836285672 1.3443265999353662 0.06483929992376646 0.15475973426068437 1.7095181791303005e-07 6.767126276526353 -0.4745658830222691 GEDNWAELMEVNHDDK(ub)VVTTER ddPTM_RPMI8226_Bortezomib_1h_R1 2 GEDNWAELMEVNHDDKVVTTER 22 1 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 47869800.0 15201700.0 17194600.0 15473500.0 True False 19929575.91347222 14629232.704025853 13872450.652292822 1.0 0.7340463624284458 0.696073549809716 24.24840767523948 -13.99999999976479 0.2741717244244789 3.0994893279945885 0.6839699495014011 0.999592363441047 0.0027299588505565213 15.091723413850604 0.1657949304196099 17.704741084626285 0.015448856968865284 1.0000000005415891e-14 13.99999999976479 -2.4155193784931877 GEDNWAELMEVNHDDK(ub)VVTTER ddPTM_RPMI8226_Bortezomib_2h_R1 2 GEDNWAELMEVNHDDKVVTTER 22 1 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 64381600.0 27452400.0 19875300.0 17053900.0 True False 26580938.588684004 27811610.938320246 12586971.983966498 1.0 1.046299055450215 0.4735337671381177 24.66388871214137 -6.887322234259508 1.0381245570690532 1.0327800150012534 0.42678512476418967 0.9791270997188752 0.03753158806265964 0.12134136511984377 0.23477019910825536 0.02763972657543644 0.06827242155145079 1.296217157516905e-07 6.887322234259508 -0.6059948902370638 down GEDNWAELMEVNHDDK(ub)VVTTER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEDNWAELMEVNHDDKVVTTER 22 1 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 87412900.0 50786900.0 22117000.0 14509000.0 True False 77047440.3197292 18170048.549090255 11641289.790479392 1.0 0.2358293601148685 0.15109249239391614 26.199243692341938 -13.999999999999998 0.3105112910679873 8.408857629638701 0.13242946012012477 0.9996731197636725 0.006902455304118317 17.306250365677215 0.1773206617728359 82.86624754445087 0.0293029784695892 1.0000000000000041e-14 13.999999999999998 -8.276428169518576 GEDNWAELMEVNHDDK(ub)VVTTER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEDNWAELMEVNHDDKVVTTER 22 1 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 36605400.0 12164000.0 14559000.0 9882400.0 True False 16661359.519739859 13915735.239825226 7548380.654416746 1.0 0.8352100693426786 0.4530471025172742 23.990002789546647 -6.95705056205981 0.47518165833157605 1.0096020851851428 0.26285086208713926 0.9996446805609106 0.004318423115267318 0.08077205481739433 0.02515574714415607 0.005336848814456348 0.031531866248887874 1.1039500867476656e-07 6.95705056205981 -0.7467512230980036 down GEDNWAELMEVNHDDK(ub)VVTTER ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GEDNWAELMEVNHDDKVVTTER 22 1 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 84190500.0 27452400.0 47462900.0 9275200.0 True False 22827886.947526157 47207207.93705193 11214601.43632064 1.0 2.0679622273216025 0.4912676088723998 24.444293987575648 -6.724259150661736 1.7438462791936906 1.646748519660322 0.4930885963691597 0.5326286269257285 0.4491827584504818 0.3470930047453572 2.0649645603010685 0.20434087692176942 0.5104480439345582 1.8868650896619695e-07 6.724259150661736 -1.1536599232911624 GEDVPLTEQTVSQVLQSAK(ub)EQIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEDVPLTEQTVSQVLQSAKEQIK 23 1 F8VVA7;P61923;P61923-4;P61923-3;F8VYK5;F8W651;P61923-2 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 54675000.0 24161000.0 16949000.0 13565000.0 True False 23394022.280062757 23716824.087867353 10011919.558722967 1.0 1.0137984739836594 0.42796913839205375 24.479636598779372 -6.901506451050026 0.951691894802318 1.0233601195034192 0.364559303191612 0.9873010861838121 0.03076066009022613 0.11030500666050859 0.17123056371317685 0.02417125129990218 0.06337860606392698 1.2545661022797582e-07 6.901506451050026 -0.6588008163118072 down GEDVPLTEQTVSQVLQSAK(ub)EQIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEDVPLTEQTVSQVLQSAKEQIK 23 1 F8VVA7;P61923;P61923-4;P61923-3;F8VYK5;F8W651;P61923-2 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 71467000.0 15226000.0 26448000.0 29793000.0 True False 23098955.16970316 21728147.760832828 23904400.491264205 1.0 0.9406550037090726 1.0348693400044984 24.461324260200115 -6.7364288876354665 1.6997977256185337 0.964546343039294 1.0348830157875164 0.5889034706285539 0.024936997665725352 0.3242608278195577 1.8381591982335166 0.011612806525297103 0.028608966399828833 1.8347255646528753e-07 6.7364288876354665 0.07033667274822242 GEDVPLTEQTVSQVLQSAK(ub)EQIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEDVPLTEQTVSQVLQSAKEQIK 23 1 F8VVA7;P61923;P61923-4;P61923-3;F8VYK5;F8W651;P61923-2 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 53772200.0 24161000.0 20790000.0 8821200.0 True False 20090942.01378313 20678000.143508095 10665672.135379482 1.0 1.0292200400221265 0.530869688840993 24.26004187421365 -6.892981672349482 1.0045568007772863 1.0248944376651952 0.48541331087198564 0.9827398120202652 0.03000006593033667 0.11675805132461377 0.2079732756942121 0.022660665716924877 0.05713600090465527 1.27943529643505e-07 6.892981672349482 -0.5394811267932096 GEDVPLTEQTVSQVLQSAK(ub)EQIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEDVPLTEQTVSQVLQSAKEQIK 23 1 F8VVA7;P61923;P61923-4;P61923-3;F8VYK5;F8W651;P61923-2 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 59644000.0 15226000.0 20347000.0 24071000.0 True False 19710357.149330467 19214671.563549515 19690324.989317086 1.0 0.9748515167926427 0.998983673412835 24.232450582292564 -10.102865574580527 4.777032683386501 1.0000006777150052 0.986917595102599 0.28153253728798877 0.009851911685880732 7.110808026755447e-08 1.3346749029933558e-08 0.009539566658899986 0.0031796908239085614 7.891043281020802e-11 10.102865574580527 -0.013083082612406205 GEELK(ub)GHNTLPSPWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEELKGHNTLPSPWR 15 1 P47897;P47897-2;A0A1B0GVU9;B4DDN1;A0A0U1RQQ5 P47897 QARS Glutamine--tRNA ligase 1 56861300.0 2616000.0 4169300.0 50076000.0 True False 3968663.2552176127 3425255.8401104184 40178456.6509095 1.0 0.8630754538337877 10.123926891022252 21.920221722833965 -6.903546878541413 0.9385902056661839 0.6515354540302304 11.169111134336005 0.9882493298678069 0.4697746677394287 0.10884081448518249 0.16306865737876658 0.37273888356273904 0.9882324216011269 1.2486856519004821e-07 6.903546878541413 10.517575680305773 up GEENLMDAQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEENLMDAQVK 11 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 16779620.0 880120.0 9035100.0 6864400.0 False True 1153845.8430942046 7687098.298543955 6154137.7359743295 1.0 6.662153652978364 5.333587474277429 20.13801905824729 -10.09160293359008 5.987822082447198 0.9999818274300937 5.997870563628068 0.9496696227389356 0.5423848712233739 0.00013159772258600777 1.9964443660237895e-05 0.5251637690699139 0.17505396445682572 8.098359769942247e-11 10.09160293359008 4.997888736197974 GEENLMDAQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEENLMDAQVK 11 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 16263700.0 3192800.0 1653900.0 11417000.0 False True 3091446.311650361 2314310.8949745614 8426545.197341703 1.0 0.7486175277419171 2.725761455272763 21.5598505202279 -6.874990024140623 1.10741025514179 0.8525006005960319 2.8530594227211328 0.9694122558812944 0.15369575166709398 0.1321579293002309 0.29992137677992087 0.10735395451174122 0.2565997902359569 1.3335520638559327e-07 6.874990024140623 2.0005588221251007 up GEENLMDAQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEENLMDAQVK 11 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 14837420.0 880120.0 5581800.0 8375500.0 False True 1205524.14834869 5335177.619455763 6397379.398837063 1.0 4.425608252446717 5.306720240818157 20.201229119770183 -9.461382892694434 0.41279947341061013 1.4359400484583656e-19 5.407869279149393 0.9982274443263823 0.0782118119089932 0.8060026105915802 0.1697734521264755 1.4388697642022863 0.2149235036883024 3.456345172004993e-10 9.461382892694434 5.407869279149393 GEEPGK(ub)SCGYSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEEPGKSCGYSVR 13 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 10775000.0 2831700.0 4403300.0 3540000.0 True False 3712386.122221806 3746344.803928963 3173714.7580777863 1.0 1.0091474002404774 0.8548988854042927 21.823915341116187 -6.892813563903127 1.0055677936344902 1.0077376120797736 0.8408758788626294 0.9826396173900408 0.009309566960208092 0.11689089588200326 0.20873998536673974 0.0070266555804036155 0.01770504413710214 1.279930641234478e-07 6.892813563903127 -0.16686173321714426 GEEPGK(ub)SCGYSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEEPGKSCGYSVR 13 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 3180200.0 1610600.0 1569600.0 0.0 True False 1559472.3845978659 2196349.4653558694 0.0 1.0 1.4083926634726733 0.0 20.57262657477336 -6.855924788057758 1.3926881080093647 1.2162985100936479 1.6027765092805853e-21 0.9032335730718373 0.18404363751380942 0.16911672167773514 0.6593336342400289 0.10643219233738695 0.22319817364800576 1.393398093376251e-07 6.855924788057758 -1.2162985100936479 down GEEPGK(ub)SCGYSVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEEPGKSCGYSVR 13 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 38780600.0 5713300.0 8591100.0 24476200.0 True False 8667493.79817844 7057951.082429323 19638468.34170042 1.0 0.8143012555616275 2.2657608760940375 23.04718346846611 -6.874766074511904 1.1085245127082528 0.8912358010587722 2.3588534983430587 0.9692151069984152 0.11315634897707223 0.13236969893687545 0.30113455768022657 0.07896630844166282 0.18867310569907753 1.3342399047479133e-07 6.874766074511904 1.4676176972842865 up GEEPGK(ub)SCGYSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEEPGKSCGYSVR 13 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 9864960.0 2831700.0 3656160.0 3377100.0 True False 3878656.0138151413 3494618.761895697 2579498.5335577186 1.0 0.9009870299011911 0.6650495749996815 21.88712540263908 -6.956481507644571 0.482473410275815 1.0055334213945022 0.5506251307094953 0.9996166200807305 0.0027509933813040467 0.08098280069721274 0.02596384564976838 0.0033435206263609735 0.019461350513680566 1.1053975364532129e-07 6.956481507644571 -0.45490829068500693 GEEPGK(ub)SCGYSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEEPGKSCGYSVR 13 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 6734910.0 1610600.0 0.0 5124310.0 True False 1339285.2616778726 0.0 6195779.528867543 1.0 0.0 4.6261836116268436 20.353031850207636 -6.85012003763674 1.234510555745125 0.4663237459559242 4.811547576293813 0.9404821466502991 0.4848718333165954 0.15732317613461594 0.46132449174450524 0.30732928349247884 0.7112333918277916 1.4121471776130823e-07 6.85012003763674 4.345223830337888 GEEPGK(ub)SCGYSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEEPGKSCGYSVR 13 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 45837600.0 5713300.0 7976700.0 32147600.0 True False 7395979.4759798795 7532789.6329171555 26297066.662231285 1.0 1.0184979092196778 3.5555894587913572 22.81830979055856 -6.908498431415129 0.9058986765715158 0.9176672768055878 3.8731502294329485 0.9903424714473715 0.11796463161937232 0.10541945560277058 0.14421509832646195 0.09586779116483866 0.2619648748609357 1.234529774037449e-07 6.908498431415129 2.955482952627361 up GEETK(ub)AMESQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEETKAMESQR 11 1 D6RDG8;O43791;A0A590UJA7;D6RGZ4;H0Y977 D6RDG8 SPOP Speckle-type POZ protein 1 1842760.0 603320.0 415050.0 824390.0 True False 584167.9368406719 580781.6294571563 608457.5278301236 1.0 0.9942031953998886 1.041579808574938 19.15602364973777 -6.8762921615866865 1.1003199872029297 0.9965569474424201 1.04470683032929 0.9705671024496644 0.003619977303148681 0.1309627378251189 0.2925939241614865 0.0025422775362404274 0.006093728291127294 1.3295596864716605e-07 6.8762921615866865 0.04814988288686983 GEETK(ub)AMESQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEETKAMESQR 11 1 D6RDG8;O43791;A0A590UJA7;D6RGZ4;H0Y977 D6RDG8 SPOP Speckle-type POZ protein 1 4290510.0 808260.0 890950.0 2591300.0 True False 1226189.5117210217 731953.0114758782 2079128.4191928606 1.0 0.5969330225705025 1.6956012095346453 20.225750538965418 -6.807418053190125 1.425461475212512 0.7796535148163978 1.713688759107906 0.8529518253203763 0.17401739103789474 0.2103440430686931 0.8428681884459376 0.09600614503609177 0.22234254339082096 1.5580519951534744e-07 6.807418053190125 0.9340352442915082 GEETK(ub)AMESQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEETKAMESQR 11 1 D6RDG8;O43791;A0A590UJA7;D6RGZ4;H0Y977 D6RDG8 SPOP Speckle-type POZ protein 1 1685210.0 603320.0 407720.0 674170.0 True False 501687.31160778314 405523.53143391636 815135.8299901127 1.0 0.8083192898267931 1.6247886106144582 18.936428925172045 -6.844828034888742 1.2597284591469338 0.8979997638790341 1.6543235705251178 0.9324471109115978 0.09060552256971768 0.16323610878510475 0.5010841925349857 0.05634732575188817 0.13003598515417425 1.4294598615408892e-07 6.844828034888742 0.7563238066460837 GEETK(ub)AMESQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEETKAMESQR 11 1 D6RDG8;O43791;A0A590UJA7;D6RGZ4;H0Y977 D6RDG8 SPOP Speckle-type POZ protein 1 3972580.0 808260.0 783320.0 2381000.0 True False 1046308.503186513 739727.5534063795 1947682.431123094 1.0 0.7069879974725936 1.8614800751322038 19.996876861057867 -6.839410597519362 1.2850284564067946 0.8441044796924786 1.8990346846347304 0.9234502832647637 0.13556995226101196 0.1694897949855314 0.5439052391856258 0.08273082764021408 0.1905774594358299 1.4474027801611328e-07 6.839410597519362 1.0549302049422518 GEETPVIVGSALCALEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEETPVIVGSALCALEGR 18 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 4263370.0 584270.0 1784800.0 1894300.0 False True 765983.6280787295 1518514.7970959109 1698296.0074086864 1.0 1.9824376676361999 2.2171440030231713 19.546954031153565 -10.622075861164998 0.2939910858738985 1.3752480774792125e-13 2.2951494779868415 0.9991229617658995 0.015613723790797458 2.259420564828876 0.14504396803927874 1.7235135290177794 0.08639975928295693 2.387394224135042e-11 10.622075861164998 2.295149477986704 GEETPVIVGSALCALEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEETPVIVGSALCALEGR 18 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 15453870.0 584270.0 6540100.0 8329500.0 False True 800290.4083030606 6251136.756781438 6362243.651437337 1.0 7.81108544089186 7.949918661311794 19.610164092676456 -10.03599086467926 0.8710234952499939 2.1484775640146064e-19 7.917277791338056 0.999941260337644 0.024862562063988396 1.3456518324458715 0.47637641967569794 3.7575460415920725 0.019212101449357703 9.204689334785698e-11 10.03599086467926 7.917277791338056 GEEVTLSNPK(ub)GSQEGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEEVTLSNPKGSQEGTK 17 1 Q14669-4;Q14669;Q14669-2;Q14669-3 Q14669-4 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 6548900.0 1494400.0 1876700.0 3177800.0 True False 1446961.0899932012 2626076.0968612144 2345438.8480434814 1.0 1.8148906111038228 1.620941201711583 20.46459469642629 -10.029312634330486 4.505456694665386 0.9999709174510272 1.7179159063268228 0.9481025120568856 0.07917951503531762 10447036.949102461 5813873.003419482 2898.450457366309 0.02710525388897448 9.347325486413434e-11 10.029312634330486 0.7179449888757956 GEEVTLSNPK(ub)GSQEGTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEEVTLSNPKGSQEGTK 17 1 Q14669-4;Q14669;Q14669-2;Q14669-3 Q14669-4 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 6772800.0 1494400.0 2986300.0 2292100.0 True False 1242659.8131450466 2970212.2091658623 2771367.512527014 1.0 2.3902054108022974 2.230190019191948 20.244999971860565 -10.123139090740288 4.674151749008687 0.9998960514346438 2.310197715014673 0.9889368281112435 0.06532601013712307 7.10854015606232e-05 1.3335529904235478e-05 0.06325659564825191 0.02108387910217207 7.531143264866502e-11 10.123139090740288 1.310301663580029 GEEVTLSNPK(ub)GSQEGTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEEVTLSNPKGSQEGTK 17 1 Q14669-4;Q14669;Q14669-2;Q14669-3 Q14669-4 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 20750300.0 4002800.0 6747600.0 9999900.0 True False 5181703.5069841 6372090.128382898 8180020.807638734 1.0 1.2297288179059935 1.5786354423045212 22.304995037323618 -6.965049858133047 0.35719909956254214 0.9689561565590923 1.851312818415156 0.9999141648965767 0.0022039889354309983 0.07794408691264557 0.014800546981966938 0.00470870666242759 0.0298517330209633 1.0838024835424635e-07 6.965049858133047 0.8823566618560637 GEFGGFGSVSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEFGGFGSVSGK 12 0 Q09028-3;Q09028;Q09028-2;Q09028-4;C9JPP3 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 86869000.0 17093000.0 33330000.0 36446000.0 False True 22409088.528847456 28357293.919322416 32674917.53471838 1.0 1.2654371855784217 1.4581100651485943 24.417580633824944 -6.974610537414573 0.09815479074590282 0.5090622009292025 2.2193667848019687 0.9999997634620601 9.115779032305202e-05 0.07483283015994677 0.002877778918222285 0.017820319485686086 0.03201640359331283 1.0602040589800418e-07 6.974610537414573 1.7103045838727662 GEFGGFGSVSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEFGGFGSVSGK 12 0 Q09028-3;Q09028;Q09028-2;Q09028-4;C9JPP3 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 52591000.0 13101000.0 0.0 39490000.0 False True 12685115.926124822 0.0 29146384.32539404 1.0 0.0 2.2976837180784027 23.5966333681054 -6.788407837848932 1.502583984788187 0.43993716571744224 2.3210937509236222 0.7961478560379505 0.42470154316760744 0.23773845412980119 1.0603891106437584 0.22249206286645934 0.5215423330422618 1.6277667093116063e-07 6.788407837848932 1.88115658520618 GEFGGFGSVSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEFGGFGSVSGK 12 0 Q09028-3;Q09028;Q09028-2;Q09028-4;C9JPP3 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 61370000.0 17093000.0 21827000.0 22450000.0 False True 23412744.020956393 20862610.967763238 17147772.37226343 1.0 0.8910792749918348 0.7324119016939971 24.480790695347835 -6.965739907880781 0.3451309973164879 1.0162183223644758 0.6019587128195559 0.9999275790788412 0.0009349798768249991 0.07771090552976843 0.01398047078060089 0.002206435521413588 0.013683086773930127 1.0820817990177362e-07 6.965739907880781 -0.4142596095449199 GEFGGFGSVSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEFGGFGSVSGK 12 0 Q09028-3;Q09028;Q09028-2;Q09028-4;C9JPP3 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 13101000.0 13101000.0 0.0 0.0 False True 10894061.972706946 0.0 0.0 1.0 0.0 0.0 23.377038643539677 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 GEFTIETEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEFTIETEGK 10 0 P41250;H7C443 P41250 GARS Glycine--tRNA ligase 0 9736200.0 3311600.0 1066000.0 5358600.0 False True 3206475.0706781964 1491659.3591165605 3955021.9054458435 1.0 0.4652022318081089 1.2334485122347523 21.612556760049312 -6.719503100273667 1.7609918866306327 0.6744628721013468 1.2322256568999412 0.5101970855821389 0.22505902496362465 0.3562965988022192 2.159063058217027 0.10148490473145788 0.25492479508489196 1.9076421059637204e-07 6.719503100273667 0.5577627847985944 GEFTYYEIQDNTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEFTYYEIQDNTGK 14 0 Q16666;Q16666-2;Q16666-3;Q16666-6 Q16666 IFI16 Gamma-interferon-inducible protein 16 0 15056800.0 2016000.0 6210700.0 6830100.0 False True 2642995.5229717703 5284087.769118985 6123386.77094551 1.0 1.9992798789070914 2.3168358469485435 21.333742550492875 -10.34267052960858 0.2551570936860085 3.576468041408088e-11 2.477037899000272 0.9991197849395647 0.016646830649708923 1.9058242150290037 0.1229517371290349 1.4019345677876647 0.139891131482912 4.542861226788236e-11 10.34267052960858 2.4770378989645074 GEFTYYEIQDNTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEFTYYEIQDNTGK 14 0 Q16666;Q16666-2;Q16666-3;Q16666-6 Q16666 IFI16 Gamma-interferon-inducible protein 16 0 7628400.0 1909700.0 1285700.0 4433000.0 False True 1849077.6188169296 1799086.7148369246 3271864.3128506425 1.0 0.9729644102165975 1.7694575282048113 20.818374355414 -6.899043126601464 0.9673014959310512 0.9660086219566153 1.8514555794060161 0.9860837515345144 0.043560914480861274 0.11211370845719143 0.18142196977463895 0.03383521318488324 0.08761795383625025 1.2617022379691042e-07 6.899043126601464 0.8854469574494008 GEFTYYEIQDNTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEFTYYEIQDNTGK 14 0 Q16666;Q16666-2;Q16666-3;Q16666-6 Q16666 IFI16 Gamma-interferon-inducible protein 16 0 9923000.0 2016000.0 3613900.0 4293100.0 False True 2761369.680351494 3454225.9484308306 3279158.1991698933 1.0 1.2509103627121536 1.1875114811691894 21.396952612015767 -10.053945249162783 4.380594747883351 0.9999848623111207 1.219210921929455 0.9409696037742183 0.025882485099468923 17934293.666010078 0.26702517866792497 2844.5611106011293 0.008860263069604808 8.831912359608845e-11 10.053945249162783 0.2192260596183342 GEFVTTVQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEFVTTVQQR 10 0 P40925;P40925-3;A0A5K1VW95;P40925-2;B9A041;B8ZZ51 P40925 MDH1 Malate dehydrogenase, cytoplasmic 0 52728800.0 9405800.0 21542000.0 21781000.0 False True 12331094.885896757 18328017.570058312 19527311.05810514 1.0 1.4863252403499319 1.5835829047458547 23.555797567466097 -11.770980428692628 0.2704132488001615 2.754327231122913e-10 1.6194228031644566 0.9993700853827442 0.006407200882935511 4.578489057004315 0.15128906480205948 2.647667121853208 0.04022611394956338 1.6944141568240684e-12 11.770980428692628 1.6194228028890238 GEFVTTVQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEFVTTVQQR 10 0 P40925;P40925-3;A0A5K1VW95;P40925-2;B9A041;B8ZZ51 P40925 MDH1 Malate dehydrogenase, cytoplasmic 0 42843800.0 9405800.0 11660000.0 21778000.0 False True 12883378.442187535 11144822.645536259 16634484.93198899 1.0 0.865054356320214 1.2911586046031367 23.61900762898899 -6.82153785142315 1.3650721422851613 0.9273719085929727 1.3007804050414942 0.8878913168946041 0.05953556943184404 0.1915062212560414 0.7007602675356583 0.03426731900902727 0.07895539225090614 1.5082111549755138e-07 6.82153785142315 0.3734084964485215 GEGDCDVVK(ub)SK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEGDCDVVKSK 11 1 Q9NV66;A0A087WUV9;Q9NV66-2;Q6NUM6;A0A087X1V1 Q9NV66 TYW1;TYW1B S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase 1 1629950.0 549440.0 576560.0 503950.0 True False 720321.1607845287 490539.4954132775 451806.08822974557 1.0 0.6810010896792378 0.6272286763555116 19.45828076122037 -13.999999999999998 0.25050504192445544 3.2241477801285416 0.6057112678120287 0.9995436391713918 0.0035146340054414294 14.018194433681568 0.1583775490050239 15.693765520268855 0.02474636862852257 1.0000000000000041e-14 13.999999999999998 -2.6184365123165128 GEGDCDVVK(ub)SK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEGDCDVVKSK 11 1 Q9NV66;A0A087WUV9;Q9NV66-2;Q6NUM6;A0A087X1V1 Q9NV66 TYW1;TYW1B S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase 1 976130.0 549440.0 0.0 426690.0 True False 752582.8160577011 0.0 325914.6099563952 1.0 0.0 0.43306145583239974 19.52149082274326 -10.756023541387933 6.514027029733927 1.02017217475877 0.21653072791620429 0.813571565566832 0.1767965990093689 0.04866767932385744 0.0018227977972025394 0.16085041098464384 0.05706085696911637 1.7537854334861382e-11 10.756023541387933 -0.8036414468425657 GEGLQLMNLMLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEGLQLMNLMLR 12 0 A0A087WUB9;Q8WYA6-3;Q8WYA6-2;Q8WYA6-4;Q8WYA6 A0A087WUB9 CTNNBL1 Beta-catenin-like protein 1 0 3803030.0 906300.0 2026300.0 870430.0 False True 1188168.0766216845 1723983.9384555356 780366.2533541374 1.0 1.450959651564899 0.6567810301493295 20.180307501554694 -6.752664205406134 1.6399759879424394 1.2643145797741453 0.6548743834379553 0.6603763193081804 0.18952636729215605 0.2954119837902279 1.5639902082064758 0.09126217656244219 0.22094450232235355 1.767403841437304e-07 6.752664205406134 -0.60944019633619 GEGLQLMNLMLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEGLQLMNLMLR 12 0 A0A087WUB9;Q8WYA6-3;Q8WYA6-2;Q8WYA6-4;Q8WYA6 A0A087WUB9 CTNNBL1 Beta-catenin-like protein 1 0 11102400.0 906300.0 3509600.0 6686500.0 False True 1241383.601836587 3354534.2673048037 5107286.412790166 1.0 2.7022543735408444 4.114188720742002 20.243517563077585 -7.362857091360154 0.19879111151638137 9.698962619446734e-25 6.304603793652914 0.9999716369201593 0.00678069166723373 0.11993275560956486 0.014628094093353847 0.12658405148663263 0.2912549334899553 4.336535526482065e-08 7.362857091360154 6.304603793652914 GEGPDVDVNLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEGPDVDVNLPK 12 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 21477500.0 8317500.0 3341400.0 9818600.0 False True 8053465.515269309 4675638.445170807 7246814.108313846 1.0 0.5805747148610535 0.8998379759091216 22.94117829737422 -10.35666236760566 5.958283974589936 1.000038145066007 0.74020634538509 0.46889655515790385 0.13033868053079278 6.605414846682698e-05 7.132154271488441e-06 0.12621837888937154 0.042066628255200626 4.3988345995953384e-11 10.35666236760566 -0.25983179968091696 GEGPEFDVNLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEGPEFDVNLSK 12 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 16440100.0 2997200.0 5929600.0 7513300.0 False True 3929358.2249260913 5044926.793399772 6735895.7886626655 1.0 1.2839060489310983 1.7142483334640133 21.905862268239606 -6.965082846267418 0.35663205491391775 0.9614610495698058 2.0513637296676963 0.999914837549193 0.0027096805281464718 0.07793291457955301 0.014761180129552343 0.0058149337189648265 0.03683210182159551 1.0837201632145892e-07 6.965082846267418 1.0899026800978904 GEGPEFDVNLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEGPEFDVNLSK 12 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 17214500.0 6598800.0 2164200.0 8451500.0 False True 6389324.706000505 3028376.346153903 6237798.610434733 1.0 0.47397440034778904 0.9762844897484289 22.607232028698828 -10.738727375052864 10.064475179830422 1.0006449950331453 0.725129445048109 0.2853344546721034 0.20506723528056142 0.002974177301080656 7.720921010344484e-05 0.1989769903337024 0.06618516559120102 1.8250409979471406e-11 10.738727375052864 -0.27551554998503636 GEGPEFDVNLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEGPEFDVNLSK 12 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 16242400.0 2997200.0 7178000.0 6067200.0 False True 4105345.8362844787 6860852.225528233 4634252.317906312 1.0 1.671199577119576 1.128833599583054 21.969072329762497 -10.41683339166303 4.055633139597622 0.9982742982024988 1.4000165883584788 0.42038627183516264 0.2214199831609341 0.0034689671326176477 0.0004988080865474212 0.21525703402732646 0.07146299227143196 3.829716344986331e-11 10.41683339166303 0.40174229015597995 GEGPEFDVNLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEGPEFDVNLSK 12 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 11111900.0 6598800.0 2748100.0 1765000.0 False True 5487194.576406282 2733295.439844862 2134053.3395620543 1.0 0.4981225655086891 0.3889151933372309 22.387637304133104 -13.999999999999984 0.21432797087574762 3.9554189970988496 0.32722755845229073 0.9994928789081265 0.005992156093724741 12.85149494043029 0.14670547128547287 16.02839468064999 0.06278194053355204 1.0000000000000368e-14 13.999999999999984 -3.628191438646559 GEGPEFDVNLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEGPEFDVNLSK 12 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7155900.0 0.0 4363300.0 2792600.0 False True 0.0 4120478.5193510414 2284375.454495733 0.0 GEGPEVDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEGPEVDVK 9 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 4877110.0 997600.0 763110.0 3116400.0 False True 965931.7340586326 1067823.8025660776 2300121.350004002 1.0 1.1054857863291403 2.381246281597353 19.8815617065463 -6.923280954184282 0.8000141671483848 0.9750392329941211 2.6033462453456107 0.9950449145635448 0.0441882030720798 0.09627944545615773 0.09589039087796163 0.03874987716649877 0.11997985861548165 1.1932159383775192e-07 6.923280954184282 1.6283070123514896 up GEGPEVDVNLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEGPEVDVNLPK 12 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 34834800.0 2169800.0 18528000.0 14137000.0 False True 2844628.812373092 15763694.62157833 12674238.851679564 1.0 5.541564703630941 4.4554983049286685 21.439808980912026 -10.055695920608764 6.492651625508081 0.9999970429400437 4.998531504279826 0.9475694944961444 0.4433847506005207 1.8978303566592765e-05 2.762759347970899e-06 0.4293057577604799 0.14310181291983468 8.796381963749473e-11 10.055695920608764 3.998534461339782 GEGPEVDVNLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEGPEVDVNLPK 12 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 31484900.0 10222000.0 4455900.0 16807000.0 False True 9897508.205239914 6235164.107211521 12404742.500807753 1.0 0.6299731182754176 1.253319749130439 23.2386339276042 -6.745898051135641 1.665088961777283 0.7813495748997562 1.25417580574579 0.6310897652642666 0.15546653362884466 0.30726385556573316 1.6747756333948653 0.07379953009937426 0.17993929576826714 1.7951549827102636e-07 6.745898051135641 0.4728262308460337 GEGPEVDVNLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEGPEVDVNLPK 12 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 46733800.0 2169800.0 18957000.0 25607000.0 False True 2972033.6966402177 18119417.05758412 19559153.99271932 1.0 6.096639172721192 6.58106737310222 21.503019042434918 -9.777199164710686 0.6045292875828966 2.0844458578229428e-22 6.527866662949995 0.9992990604476212 0.06683727453871127 1.0540732232614412 0.28243922604513644 2.28867265027481 0.08329215703971181 1.670324438388242e-10 9.777199164710686 6.527866662949995 GEGPEVDVNLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEGPEVDVNLPK 12 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 13074200.0 10222000.0 1835000.0 1017200.0 False True 8500045.911381615 1825114.4907810201 1229891.816998594 1.0 0.21471819209084275 0.1446923734084496 23.019039203038478 -13.970932371944489 0.34223711650584254 9.999999998709614 0.13393840885379393 0.9997386842538563 0.006268012758651393 19.49884527304446 0.1876278513006775 126.98650062385154 0.021476280891897955 1.069221364718395e-14 13.970932371944489 -9.86606158985582 GEGQLGPAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEGQLGPAER 10 0 P13639 P13639 EEF2 Elongation factor 2 0 26452180.0 496180.0 13666000.0 12290000.0 False True 650496.7850139547 11627086.069650771 11018348.694004524 1.0 17.874163773770753 16.93835995479694 19.311182401086437 -9.287837538600142 10.712816313663238 1.0000000141033059 17.40626185514371 0.9975658173044277 0.3820403093057211 0.0 0.0 0.369908944392271 0.12330297962673273 5.154214179843126e-10 9.287837538600142 16.406261841040404 GEGQLGPAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEGQLGPAER 10 0 P13639 P13639 EEF2 Elongation factor 2 0 16551600.0 4700100.0 2027300.0 9824200.0 False True 4550897.898204667 2836811.4622298377 7250947.300317451 1.0 0.6233520341884538 1.5933003689619045 22.117719788368976 -6.801420210842177 1.4502601844060998 0.7925601790372729 1.6071404945049577 0.836241531780054 0.16156841110991593 0.21873733316328828 0.9081431441581053 0.0876399785452235 0.20363051845835242 1.5797188091129971e-07 6.801420210842177 0.8145803154676847 GEGQLGPAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEGQLGPAER 10 0 P13639 P13639 EEF2 Elongation factor 2 0 19889380.0 496180.0 9065200.0 10328000.0 False True 679631.1547603195 8664669.48939238 7888739.111836807 1.0 12.749076361056586 11.607382999707937 19.37439246260933 -10.167063830540037 6.3308401898559525 0.9999404080973696 12.178229680382286 0.9922370002008758 0.4660943630046143 0.00039203096684483344 5.1582365718990345e-05 0.4512960009179399 0.15043130880648944 6.806693097996127e-11 10.167063830540037 11.178289272284916 GEHSIVYLKPSYAFGSVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEHSIVYLKPSYAFGSVGK 19 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 201581000.0 58022000.0 58766000.0 84793000.0 False True 76067403.88584733 49998341.868073866 76019433.7518897 1.0 0.6572899732861301 0.9993693733254048 26.180775032177458 -10.98673914067613 9.283319875119101 1.129297591383693 0.8283296733056783 0.2513826272246351 0.13965333026893778 0.0766179532476052 0.0001094457955889925 0.027721773396079414 0.04507291853116669 1.0310052085886703e-11 10.98673914067613 -0.3009679180780146 GEHSIVYLKPSYAFGSVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEHSIVYLKPSYAFGSVGK 19 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 175782600.0 55079000.0 21677600.0 99026000.0 False True 53330547.293720335 30333578.72719061 73088119.88367872 1.0 0.5687843134278576 1.3704738389640496 25.668458797668123 -6.760628486903939 1.6103479225129533 0.7497193471857567 1.3734694742379148 0.6934414696991227 0.18138543635509433 0.2818596203155052 1.4407624734166158 0.08887026623746999 0.21341614915383836 1.735287798503235e-07 6.760628486903939 0.623750127052158 GEHSIVYLKPSYAFGSVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEHSIVYLKPSYAFGSVGK 19 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 131511000.0 25659000.0 81606000.0 24246000.0 False True 38926578.92417002 67042771.70941179 19453767.472600695 1.0 1.7222877931300578 0.49975538591503604 25.214252222716148 -6.746643701608797 1.6622959674459883 1.4264401029410896 0.4979512493845774 0.634297072914231 0.30347553225739166 0.3059853848335597 1.6624575964300798 0.14428338190431805 0.3515202397635477 1.7920754830291958e-07 6.746643701608797 -0.9284888535565121 GEHSIVYLKPSYAFGSVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEHSIVYLKPSYAFGSVGK 19 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 202988000.0 58022000.0 49597000.0 95369000.0 False True 79474301.38559254 47405640.54465363 72844806.38620889 1.0 0.5964901825893564 0.916583161049523 26.24398509370035 -9.870713783326948 6.352234423861068 1.0000000163283622 0.7565366718194034 0.4354600002493292 0.13067741124597923 3.0179696214752384e-08 5.342595902176702e-09 0.12652786879728967 0.04217595312341213 1.346747619840272e-10 9.870713783326948 -0.2434633445089588 GEHSIVYLKPSYAFGSVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEHSIVYLKPSYAFGSVGK 19 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 118389000.0 55079000.0 30182000.0 33128000.0 False True 45800628.91342086 30019403.575342078 40054911.633434385 1.0 0.655436492631776 0.8745493802967665 25.4488640731024 -10.683016331067668 5.900214208697357 1.0031681765015221 0.7649929364642718 0.6053336524039736 0.08945246180783287 0.0037712474896278905 0.0002026065860430278 0.0876176785946795 0.028870657904915963 2.074835494552553e-11 10.683016331067668 -0.23817524003725032 GEHSIVYLKPSYAFGSVGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEHSIVYLKPSYAFGSVGK 19 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 141386000.0 25659000.0 68788000.0 46939000.0 False True 33216081.314506102 64959887.33048821 38396583.63481172 1.0 1.9556758280850841 1.1559636813040675 24.985378544808597 -10.130564020501897 4.1997546203695695 0.9998809156857404 1.555819754761989 0.39175681358746783 0.32648111705492244 41789401.194406964 25200931.92037408 43863.685817086145 0.11176317187305315 7.403481227252944e-11 10.130564020501897 0.5559388390762485 GEIGDATPFNDAVNVQK(ub)ISNLLSDYGYHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEIGDATPFNDAVNVQKISNLLSDYGYHLR 30 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 243764000.0 28635000.0 35775000.0 179354000.0 True False 43441388.49891304 29390671.738649204 143904603.28634927 1.0 0.6765592158589635 3.312615187011114 25.37256688034834 -6.876191479793309 1.1007659923403603 0.8080406212294255 3.486344247712279 0.9704838453209486 0.20167282835742736 0.13105973836418036 0.2930972987565676 0.14157700513692342 0.3393065825244636 1.3298679518928753e-07 6.876191479793309 2.6783036264828537 up GEIGDATPFNDAVNVQK(ub)ISNLLSDYGYHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEIGDATPFNDAVNVQKISNLLSDYGYHLR 30 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 153087000.0 28635000.0 24992000.0 99460000.0 True False 37068571.98023631 23601173.23026637 81359300.54578021 1.0 0.6366895720409652 2.194832339081155 25.14369320244079 -6.845299450343336 1.257655216886224 0.8066544708176159 2.2516634429306834 0.9331683558522976 0.17207438530291247 0.16270431416661607 0.4976133587364492 0.10718345652769233 0.2473825409334409 1.4279090615725498e-07 6.845299450343336 1.4450089721130674 up GEIIAK(ub)QGGGGGGGSVPGIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEIIAKQGGGGGGGSVPGIER 21 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 190802200.0 37199000.0 52913800.0 100689400.0 True False 48768249.235628426 45019267.29637698 90271026.76892571 1.0 0.9231265834223844 1.851020452523786 25.539438845229686 -6.886794192951095 1.0411214623574672 0.9462448825572151 1.9260011558732375 0.9787672828210722 0.06126813854679708 0.12178439495557264 0.23733048458977113 0.04501576809336429 0.11100888529696111 1.297794134666161e-07 6.886794192951095 0.9797562733160224 GEIIAK(ub)QGGGGGGGSVPGIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEIIAKQGGGGGGGSVPGIER 21 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 330845100.0 69217400.0 97798700.0 163829000.0 True False 67020131.52468928 136850230.92348287 120917270.13535014 1.0 2.0419272211226436 1.804193268269041 25.9980911819958 -10.066952853514437 5.502311545213244 0.999993223532685 1.923060244696292 0.9526087503134018 0.09705447983929637 8.07382849269082e-06 1.368938919277476e-06 0.09397328426212238 0.03132419867413668 8.57130889276268e-11 10.066952853514437 0.9230670211636071 GEIIAK(ub)QGGGGGGGSVPGIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEIIAKQGGGGGGGSVPGIER 21 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 329573000.0 54780000.0 44907000.0 229886000.0 True False 83105264.95444234 36892994.99000756 184448931.33738697 1.0 0.44393089908602074 2.2194614437304354 26.308436542928625 -6.822536946002028 1.360861357527152 0.7010283680424769 2.260374469827386 0.8901217835026514 0.24580167515604068 0.19020312655594906 0.6914400763215086 0.14191205236055618 0.3268842840092979 1.504745502680921e-07 6.822536946002028 1.559346101784909 up GEIIAK(ub)QGGGGGGGSVPGIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEIIAKQGGGGGGGSVPGIER 21 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 147376500.0 37199000.0 52168500.0 58009000.0 True False 50952475.56517622 49863523.17184025 44308468.93285646 1.0 0.9786280768253738 0.8696038502816016 25.602648906752577 -6.939362208024741 0.6655035794359341 1.0012383046008984 0.8407502051622239 0.9980787104522021 0.0025029369862730848 0.08805958839298077 0.05595089760563122 0.0024247499173016256 0.009410226479440356 1.1498410045161476e-07 6.939362208024741 -0.16048809943867448 GEIIAK(ub)QGGGGGGGSVPGIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEIIAKQGGGGGGGSVPGIER 21 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 234276500.0 69217400.0 89779100.0 75280000.0 True False 57557334.9507402 89295442.1685439 91020699.94460699 1.0 1.5514172476013075 1.5813918421084998 25.778496457430077 -11.495504183889008 0.47655119275940716 1.6719566907491846e-15 1.5806751009511677 0.9998249664090739 0.0035361951648263928 4.126937080600047 0.23498239710053445 4.271601824000913 0.006385603290071328 3.1951835830266858e-12 11.495504183889008 1.580675100951166 GEIIAK(ub)QGGGGGGGSVPGIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEIIAKQGGGGGGGSVPGIER 21 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 377798000.0 54780000.0 53829000.0 269189000.0 True False 70913789.87523468 50833368.83050614 220199364.11238724 1.0 0.7168333397487581 3.1051698759832855 26.079562865021074 -6.877313005448048 1.0946330010211212 0.8300075889779867 3.265972264730228 0.9714545596213245 0.1800069007314006 0.1300388666823364 0.2868717198011093 0.1269632057904061 0.30505041127551435 1.3264381204357716e-07 6.877313005448048 2.4359646757522415 up GEINK(ub)VVNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEINKVVNK 9 1 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3;J3QLR1 Q9Y265 RUVBL1 RuvB-like 1 1 6358600.0 2678800.0 2540400.0 1139400.0 True False 3511932.7415361023 2161382.222401641 1021505.8178965623 1.0 0.6154395261727771 0.2908671358693961 21.743833784817753 -7.684502489011723 0.26520940472047155 1.1313411958304025 3.589207049740716e-11 0.9997182603449556 0.004865114078837785 0.1275224394447195 0.03490099430471384 0.03749184905425313 0.07805565224950665 2.067747531290873e-08 7.684502489011723 -1.1313411957945103 down GEINK(ub)VVNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEINKVVNK 9 1 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3;J3QLR1 Q9Y265 RUVBL1 RuvB-like 1 1 10003600.0 3104400.0 4643200.0 2256000.0 True False 3005852.521262647 6497253.9739681175 1665085.9214507185 1.0 2.1615345157515784 0.5539479763801843 21.519342796122526 -6.712838344423198 1.7848625786588683 1.7119916923889176 0.5573603628449323 0.4786870485661717 0.4892516467890301 0.369392156526697 2.295599576390019 0.21798311112628155 0.5519284724044188 1.9371428841731645e-07 6.712838344423198 -1.1546313295439852 GEINK(ub)VVNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEINKVVNK 9 1 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3;J3QLR1 Q9Y265 RUVBL1 RuvB-like 1 1 14818500.0 5554700.0 2797000.0 6466800.0 True False 8426886.002965335 2297853.496939252 5188634.145500872 1.0 0.2726812129807691 0.6157237849989955 23.006568178184853 -10.603324002779287 6.55409951790795 1.0013965697394196 0.44420249899185904 0.7777808944345447 0.14004654358276752 0.0028638241730982814 0.00017332832631571034 0.13587967609821855 0.045199827582497465 2.4927343436402974e-11 10.603324002779287 -0.5571940707475606 GEINK(ub)VVNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEINKVVNK 9 1 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3;J3QLR1 Q9Y265 RUVBL1 RuvB-like 1 1 5818120.0 2678800.0 2198600.0 940720.0 True False 3669224.7518480094 2101458.582202058 718541.3107365547 1.0 0.572725500432661 0.19582918990575884 21.807043846340644 -7.798987858532969 0.3411006387607605 1.0795367752785958 2.066193772580894e-21 0.9989692633834928 0.010547034068910319 0.11619173347567921 0.056555630210066155 0.03765597138024736 0.08077653731558297 1.5885911598403507e-08 7.798987858532969 -1.0795367752785958 down GEINK(ub)VVNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEINKVVNK 9 1 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3;J3QLR1 Q9Y265 RUVBL1 RuvB-like 1 1 10420800.0 3104400.0 5804600.0 1511800.0 True False 2581446.148238415 5773329.467677106 1827910.3902265795 1.0 2.2364710073912795 0.7080954958033697 21.299748071556802 -6.6914623139318055 1.8610093137903194 1.7741372691495678 0.7132615611144821 0.37727199995241356 0.5227890916375628 0.41359070267484555 2.7782669665152775 0.2246232754589814 0.5839041144590842 2.0348747652180986e-07 6.6914623139318055 -1.0608757080350857 GEINK(ub)VVNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEINKVVNK 9 1 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3;J3QLR1 Q9Y265 RUVBL1 RuvB-like 1 1 18502400.0 5554700.0 5104000.0 7843700.0 True False 7190668.649506502 4819957.913223418 6416227.083158421 1.0 0.6703073313709448 0.8922990887083595 22.777694500277303 -9.884406229129171 5.212528361930661 1.0000001984414542 0.7813032100438239 0.5640890287282683 0.09062775544353775 123476295.43964161 77.7723608365078 496.07911549894834 0.031024291243237145 1.3049496969720306e-10 9.884406229129171 -0.2186969883976303 GEK(ub)EEEDKDDEEKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEKEEEDKDDEEKPK 15 3 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 75084400.0 34545400.0 39300300.0 1238700.0 True False 45289353.93812943 33436848.431369558 1110531.206449423 1.0 0.7382937826193814 0.02452080036218973 25.43266862340736 -7.335215949896895 0.7449493402232401 0.9918925855248176 3.212952862331868e-19 0.9907425777494263 0.039664464598376255 0.10560481846103568 0.11776068710119622 0.03460927922997085 0.06871204429307294 4.62151162819352e-08 7.335215949896895 -0.9918925855248176 down GEK(ub)EEEDKDDEEKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEKEEEDKDDEEKPK 15 3 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 29988210.0 21927800.0 3030500.0 5029910.0 True False 21231713.991670866 4240594.453848728 3712425.676934482 1.0 0.1997292566917725 0.17485284882750657 24.3397175058962 GEK(ub)EEEDKDDEEKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEKEEEDKDDEEKPK 15 3 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 45451520.0 34545400.0 5128700.0 5777420.0 True False 47317767.934332564 4902097.075657099 4412912.385699866 1.0 0.10359949950429218 0.0932612119790623 25.49587868493025 GEK(ub)EEEDKDDEEKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEKEEEDKDDEEKPK 15 3 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 48314000.0 21927800.0 25084000.0 1302200.0 True False 18233937.266248643 24948867.513215832 1574483.9993074792 1.0 1.3682655122103908 0.08634909599156504 24.120122781330476 -6.829860478632667 1.328356796063801 1.1967886316380818 0.051895769172158455 0.9056611373158923 0.16552014775633317 0.1809544402720568 0.6244895547153909 0.09783489818223744 0.22516764018497173 1.479583642599591e-07 6.829860478632667 -1.1448928624659234 down GEKDTAK(ub)SLQPLAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEKDTAKSLQPLAPR 15 2 Q14764 Q14764 MVP Major vault protein 1 4163840.0 707240.0 1198300.0 2258300.0 True False 684789.0533236038 1676787.4390519485 1666783.4824521975 1.0 2.4486189300394177 2.4340101150310627 19.385300114198685 -10.299829512037876 5.660559338037942 0.9998431797403116 2.441314522535256 0.999922955673448 0.00596402375292013 1.1804515192742877e-05 1.4601244654532043e-06 0.005775244985299271 0.001924880389278882 5.0138401983434386e-11 10.299829512037876 1.4414713427949446 GELGCFLSHYNIWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GELGCFLSHYNIWK 14 0 Q8NBJ5;M0QX72 Q8NBJ5 COLGALT1 Procollagen galactosyltransferase 1 0 5758050.0 565050.0 1100900.0 4092100.0 False True 773964.2549020903 1052258.597810535 3125630.259444952 1.0 1.359570020379882 4.038468494698579 19.56190741229704 -6.9314455877194225 0.7348284581940255 0.9613687149594555 4.609242940038823 0.9968148317332278 0.07650458396210039 0.09189407586458764 0.07405342261888152 0.07030857980918324 0.24049609044306025 1.1709933056002511e-07 6.9314455877194225 3.6478742250793674 up GELLLQLCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GELLLQLCR 9 0 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 0 7747200.0 2388500.0 3082300.0 2276400.0 False True 3131346.630266903 2622432.8547113 2040859.964770697 1.0 0.8374776619628901 0.6517515324059613 21.578351788464225 -6.969384080859546 0.27251058298230607 1.044787442013761 0.43883956736614793 0.9999771645345172 0.0006798670174006209 0.07650320470936366 0.009743925367227351 0.0035855235888476653 0.017214607453094753 1.073040018681006e-07 6.969384080859546 -0.6059478746476131 GELLLQLCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GELLLQLCR 9 0 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 0 20029900.0 4665900.0 7380100.0 7983900.0 False True 7078511.422981606 6063063.49401551 6405878.665532314 1.0 0.8565449897178566 0.9049753942240634 22.755014569677975 -10.131375958401724 6.717102471801088 1.0000001744957525 0.8807601929178109 0.8898980045857339 0.019771629846132503 5.166746211504008e-08 6.667563636489999e-09 0.019143826236211182 0.006381266093454034 7.389652934142056e-11 10.131375958401724 -0.11923998157794158 GEMK(ub)GSAITGPVAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 GEMKGSAITGPVAK 14 1 P62829;J3KTJ3 P62829 RPL23 60S ribosomal protein L23 1 47484000.0 13899900.0 14537600.0 19046500.0 True False 18222903.506823096 12368646.74712097 17075750.886928953 1.0 0.6787418230300045 0.9370488561570541 24.119249510352844 -9.921221371201908 6.178717879076491 1.0000000415020076 0.8078953408252043 0.4244492096445579 0.10545340468901605 6.026899661169913e-08 1.0588553678816847e-08 0.10210484286248445 0.03403494001343702 1.1988880429330164e-10 9.921221371201908 -0.1921047006768033 GEMK(ub)GSAITGPVAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 GEMKGSAITGPVAK 14 1 P62829;J3KTJ3 P62829 RPL23 60S ribosomal protein L23 1 59235800.0 19731600.0 26378400.0 13125800.0 True False 19105231.158531755 36911432.68153871 9687759.21444054 1.0 1.9320065994100941 0.5070736456446543 24.187464377507585 -6.730212977167327 1.722317132277736 1.5607356399711771 0.5078654901729268 0.5603281519239367 0.39178642732732216 0.3358316798886751 1.9517268632236509 0.1802539188414642 0.4472033612373491 1.8611741966312355e-07 6.730212977167327 -1.0528701497982502 GEMK(ub)GSAITGPVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEMKGSAITGPVAK 14 1 P62829;J3KTJ3 P62829 RPL23 60S ribosomal protein L23 1 36391600.0 23324100.0 5371400.0 7696100.0 True False 35384364.92011515 4412831.703060248 6174962.461679535 1.0 0.1247113439233061 0.17451104394893968 25.076608690198704 -10.641058767671495 6.207884778762375 1.0050274957970118 0.14961119395712266 0.9974345468469568 0.020330642401078115 0.001415678132329109 8.185473444380965e-05 0.01969939926100254 0.006561686619756156 2.2852895426369867e-11 10.641058767671495 -0.8554163018398891 GEMK(ub)GSAITGPVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GEMKGSAITGPVAK 14 1 P62829;J3KTJ3 P62829 RPL23 60S ribosomal protein L23 1 48313100.0 13899900.0 11070800.0 23342400.0 True False 19039068.660673507 10581655.44976009 17829405.871818345 1.0 0.5557864010237654 0.9364641826543857 24.182459571875736 -10.131638459657182 7.535439103565278 1.0000000726329912 0.7461252918390756 0.37225783734699713 0.15541105356827647 1.8966580634993486e-07 2.17221194992811e-08 0.15047614817449365 0.05015870185720697 7.385187744885726e-11 10.131638459657182 -0.25387478079391557 GEMK(ub)GSAITGPVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GEMKGSAITGPVAK 14 1 P62829;J3KTJ3 P62829 RPL23 60S ribosomal protein L23 1 72651600.0 19731600.0 31710700.0 21209300.0 True False 16407699.658092082 31539868.165018857 25644066.56927673 1.0 1.9222602084542528 1.562928814133271 23.96786965294186 -10.179144521032848 4.732318467428506 0.9999031322773425 1.7425945112980221 0.8506225588254567 0.1466964274563053 0.00014995247551970054 2.601037550722185e-05 0.14205657064030036 0.04734606837177264 6.61996173269308e-11 10.179144521032848 0.7426913790206796 GEMK(ub)GSAITGPVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GEMKGSAITGPVAK 14 1 P62829;J3KTJ3 P62829 RPL23 60S ribosomal protein L23 1 71989000.0 34365100.0 23639800.0 13984100.0 True False 44486299.387393706 22324224.348945707 11439137.288982963 1.0 0.5018224634632529 0.2571384324276819 25.406857756487728 -9.745799592483264 0.1857688381819689 1.584128071810172 6.4066172417997685e-21 0.999552163738096 0.006541250411053796 1.2047206334140885 0.0792534754768211 0.5246181448756465 0.1560615802273287 1.795562007401033e-10 9.745799592483264 -1.584128071810172 GEMMDLQHGSLFLQTPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEMMDLQHGSLFLQTPK 17 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 91958000.0 18764600.0 36019100.0 37174300.0 False True 24600572.3166449 30645190.6813521 33327860.03706524 1.0 1.2457104772565546 1.3547595400662855 24.552188543547633 -13.271407816279337 0.11688596078584745 4.5585958680350046e-21 1.5431142954853942 0.9997274862488792 0.002449263698420814 9.333965637753055 0.09801052513817038 2.293231159705708 0.15942929921704718 5.3529376362856054e-14 13.271407816279337 1.5431142954853942 GEMMDLQHGSLFLQTPK ddPTM_RPMI8226_Bortezomib_2h_R1 3 GEMMDLQHGSLFLQTPK 17 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 111829370.0 29066900.0 16375570.0 66386900.0 False True 28144187.169916656 22914420.498469416 48998179.32569012 1.0 0.8141795092580488 1.740969779296533 24.746333646655533 -6.85455391066341 1.2128560221803084 0.9003042620607893 1.7814176763259777 0.9466803175378763 0.09244454443575545 0.15251850143389356 0.4294489229601668 0.059563929692754904 0.1383025664924563 1.3978033897806847e-07 6.85455391066341 0.8811134142651884 GEMMDLQHGSLFLQTPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEMMDLQHGSLFLQTPK 17 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 120876400.0 5483000.0 107498000.0 7895400.0 False True 8318111.860993189 88314142.01429245 6334870.729323251 1.0 10.617089970673666 0.7615755636840958 22.987824655632682 -6.651767675993947 2.0020835234721965 7.231853541688389 0.8029481917851093 0.2012431467244803 4.102916961289596 0.5042615687270836 3.8762387930200766 1.6608037408082783 4.545340387615671 2.229627560187731e-07 6.651767675993947 -6.42890534990328 GEMMDLQHGSLFLQTPK ddPTM_RPMI8226_Carfilzomib_1h_R1 3 GEMMDLQHGSLFLQTPK 17 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 140328400.0 27269200.0 57347400.0 55711800.0 False True 37351360.1624211 54813602.24550822 42553820.260537416 1.0 1.4675128832565443 1.1392843547194424 25.154657444410798 -10.217116387549643 8.906480043241583 0.9999999676962223 1.3033986189879934 0.5325431550843382 0.1339987356567411 8.609731076637165e-08 7.380390543675077e-09 0.12974372950278798 0.04324790596761735 6.065737507482869e-11 10.217116387549643 0.303398651291771 GEMMDLQHGSLFLQTPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEMMDLQHGSLFLQTPK 17 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 44729000.0 22513000.0 11299000.0 10917000.0 False True 18720556.995004326 11238130.044324104 13199694.225495147 1.0 0.6003095980169316 0.7050908917409643 24.158120024452085 -10.067444463411574 7.273572166497959 1.0000000572393222 0.6527002448789508 0.9360943228312637 0.042776784035428374 3.9725538101990304e-08 5.091169117891665e-09 0.0414184498323552 0.013806147681127093 8.561611886614085e-11 10.067444463411574 -0.34729981236037133 GEMMDLQHGSLFLQTPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEMMDLQHGSLFLQTPK 17 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 21269000.0 5483000.0 10889000.0 4897000.0 False True 7097851.5860881945 10283017.57779972 4005796.247463153 1.0 1.4487507174642056 0.5643674284926615 22.75895097772513 -6.768787495090461 1.5793799814062113 1.257791567442572 0.5596526438586774 0.7258051788051465 0.1890647006247488 0.26839122149436956 1.3211170791158204 0.09437302058634413 0.2248717205435507 1.7029915964615909e-07 6.768787495090461 -0.6981389235838945 GEMMDLQHGSLFLQTPK(ub)IVADKDYSVTANSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEMMDLQHGSLFLQTPKIVADKDYSVTANSK 31 2 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 1 9784800.0 4284000.0 2813200.0 2687600.0 True False 3562335.8133788696 2798044.7332235198 3249564.7339416235 1.0 0.7854522649759903 0.9122005628266182 21.764392091788523 -10.226947229836517 5.0650156731164575 1.0000183633086202 0.848826413942683 0.6547835565405731 0.05174477591704766 1.0731353844683857e-05 1.63784167415685e-06 0.050107747477834454 0.01670055461495019 5.92997374004081e-11 10.226947229836517 -0.15119194936593716 GEMMDLQHGSLFLQTPK(ub)IVADKDYSVTANSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEMMDLQHGSLFLQTPKIVADKDYSVTANSK 31 2 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 1 53795300.0 12553000.0 16962300.0 24280000.0 True False 16250105.956623212 16018333.093939967 19861289.133838147 1.0 0.985737147603719 1.222225208060449 23.953945789281644 -6.892564661660163 1.0071198595115947 0.9880633609715752 1.24361505340334 0.9824886027726135 0.01432828818984541 0.11708571494474714 0.2099054388328832 0.010802403530120663 0.02719064083021299 1.2806644035306576e-07 6.892564661660163 0.2555516924317649 GEMMDLQHGSLFLR ddPTM_RPMI8226_Bortezomib_1h_R1 3 GEMMDLQHGSLFLR 14 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 0 145424200.0 30863100.0 50787400.0 63773700.0 False True 40461822.978685535 43210117.8877347 57175009.284526944 1.0 1.0679231608149962 1.4130606353214874 25.27005798517204 -6.939446266300799 0.664697010993282 0.9960865693579064 1.50463586113303 0.9980904470131926 0.007902752230406134 0.08802016891454498 0.05576728399000799 0.007660833680946294 0.029778498516051924 1.1496184727928809e-07 6.939446266300799 0.5085492917751235 GEMMDLQHGSLFLR ddPTM_RPMI8226_Bortezomib_2h_R1 3 GEMMDLQHGSLFLR 14 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 0 137329200.0 38253100.0 15801700.0 83274400.0 False True 37038776.279188275 22111401.214776922 61462336.461549595 1.0 0.5969797989033753 1.6594051595620527 25.142533098524844 -6.803917711976182 1.439865948621132 0.7787259137135226 1.6755280343641514 0.8433608241506876 0.1733196636610789 0.2152189189694833 0.8804440148103708 0.09467851947273373 0.219683066276302 1.5706603772942725e-07 6.803917711976182 0.8968021206506288 GEMMDLQHGSLFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEMMDLQHGSLFLR 14 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 0 109105200.0 5755600.0 100370000.0 2979600.0 False True 8731665.99072268 82458189.30561058 2390680.753994927 1.0 9.443580342310584 0.2737943430881351 23.057825513814084 -6.664641012822498 1.9562928577179597 6.414140747391075 0.3115460413469566 0.255537044081687 3.59113938264106 0.4735588631024959 3.4886272598776555 1.4805550875794031 3.9836342404543426 2.1645069627241468e-07 6.664641012822498 -6.102594706044118 GEMMDLQHGSLFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 3 GEMMDLQHGSLFLR 14 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 0 139318600.0 30863100.0 51171600.0 57283900.0 False True 42274022.11391677 48910669.5101477 43754622.61895326 1.0 1.156991151169553 1.0350238853792213 25.333268046694933 -10.561788099571588 6.524237423959299 0.9998671667608071 1.0960075182743871 0.4524019879751564 0.04979292775145451 9.633961144364195e-05 6.470760443761776e-06 0.048278311007338606 0.016070598328357708 2.7429121638084287e-11 10.561788099571588 0.09614035151358002 GEMMDLQHGSLFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GEMMDLQHGSLFLR 14 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 0 71738100.0 33971200.0 15391300.0 22375600.0 False True 28248557.97933151 15308384.011966141 27054234.506914806 1.0 0.5419173616991974 0.9577209047877577 24.751673887521097 -10.392210294481258 8.615860023010997 1.000001450851846 0.7498191332434776 0.32555131940351223 0.16975108563472197 4.730725034000737e-06 3.3372812626150135e-07 0.16436173450936042 0.05478692730532564 4.0531222725721465e-11 10.392210294481258 -0.2501823176083684 GEMMDLQHGSLFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEMMDLQHGSLFLR 14 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 0 18979000.0 5755600.0 7970200.0 5253200.0 False True 7450737.659837546 7526651.363631116 4297171.502383801 1.0 1.010188750061994 0.5767444377416847 22.828951835906533 -6.901516910335712 0.9516176221915497 1.017278658218007 0.5298174146132588 0.9873062921672193 0.02275510317252373 0.1102976673999064 0.17118488172419252 0.017881499302699697 0.04688943995309324 1.2545358884322108e-07 6.901516910335712 -0.4874612436047481 GEMQVVPVLVHLLSAISSVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEMQVVPVLVHLLSAISSVR 20 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 805550000.0 325640000.0 232300000.0 247610000.0 False True 494019687.47288424 190844250.03181592 198669774.96868145 1.0 0.3863089971334209 0.4021495094354636 28.87999329575407 -9.874528300978383 6.702252695376125 1.0000000173425396 0.3942292533317952 0.9994874210176512 0.006466862067448302 1.6724620917503572e-09 2.923464816392731e-10 0.00626151245893912 0.0020871707574439896 1.3349705928205356e-10 9.874528300978383 -0.6057707640107444 GEMQVVPVLVHLLSAISSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEMQVVPVLVHLLSAISSVR 20 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 506559000.0 325640000.0 84064000.0 96855000.0 False True 421547399.3240492 79385764.50180508 79228383.81622304 1.0 0.188319900986461 0.1879465605606052 28.65111961784652 GENHLTVTWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GENHLTVTWK 10 0 Q7KZ85;Q7KZ85-2 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 19887000.0 6626800.0 5021800.0 8238400.0 False True 8687798.974022476 4272567.014823085 7385969.396313 1.0 0.4917893505131224 0.850154270189481 23.050559290498654 -9.971809566943543 6.306771743705081 1.0000001078129024 0.6709718103512908 0.5291831282027184 0.14630186582014224 2.217358696164239e-07 3.6147023544698926e-08 0.1416562188982661 0.047218724153366365 1.0670639137216623e-10 9.971809566943543 -0.32902829746161155 GENHLTVTWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GENHLTVTWK 10 0 Q7KZ85;Q7KZ85-2 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 11627630.0 3237730.0 1396700.0 6993200.0 False True 3134950.033393799 1954409.5936942783 5161471.128496978 1.0 0.6234260746983886 1.6464285151330884 21.580011018045443 -6.807054797821701 1.4268224443343414 0.7940450273761684 1.6631544174777513 0.8520142256475269 0.1625137559280971 0.21084276057214893 0.8465168224533071 0.08957273992944759 0.2074955835713937 1.5593557361346797e-07 6.807054797821701 0.8691093901015828 GENHLTVTWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GENHLTVTWK 10 0 Q7KZ85;Q7KZ85-2 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 8266500.0 0.0 5742200.0 2524300.0 False True 0.0 4717459.545986626 2025370.9985600081 0.0 GENHLTVTWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GENHLTVTWK 10 0 Q7KZ85;Q7KZ85-2 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 17223140.0 6626800.0 3661640.0 6934700.0 False True 9076907.042536343 3499856.6373757594 5296866.684629624 1.0 0.3855781072753832 0.5835541401721275 23.113769352021546 -10.093455807871583 5.140212805361077 1.0000112808776929 0.4845661237227076 0.9003758929347543 0.08082337698656339 1.0448953582294322e-05 1.8428801286859617e-06 0.07825860870561077 0.026085632753909224 8.06388252132821e-11 10.093455807871583 -0.5154451571549853 GENHLTVTWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GENHLTVTWK 10 0 Q7KZ85;Q7KZ85-2 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 13856700.0 0.0 9323400.0 4533300.0 False True 0.0 8804544.594072718 3708285.9155860236 0.0 GENLVSMTVEGPPPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GENLVSMTVEGPPPK 15 0 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 19478600.0 4227500.0 8973300.0 6277800.0 False True 5542293.439168235 7634518.617649448 5628233.476909801 1.0 1.3775016969861498 1.0155062229535186 22.402051666290305 -10.209407825922987 4.675786004342462 0.9999604885822502 1.196503959970914 0.2820701263677525 0.14778403343322422 6.08839436146905e-05 1.0294103436019681e-05 0.14312002040667385 0.04769709169298976 6.174363218383026e-11 10.209407825922987 0.1965434713886638 GENLVSMTVEGPPPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GENLVSMTVEGPPPK 15 0 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 15169400.0 4071800.0 2558900.0 8538700.0 False True 3942542.9377906374 3580682.114487215 6302158.314490805 1.0 0.9082163900271418 1.5985008695992728 21.910695036654555 -6.873393128965395 1.1159384450174272 0.9468518629310932 1.6416315897250255 0.9679563804296285 0.05478911303101346 0.13364567486090945 0.30899638985409844 0.03801785842740737 0.09058185550960542 1.3384645435198052e-07 6.873393128965395 0.6947797267939323 GENLVSMTVEGPPPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GENLVSMTVEGPPPK 15 0 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 19786000.0 4227500.0 6324300.0 9234200.0 False True 5790520.993891838 6044871.514336618 7053272.144318708 1.0 1.0439253256681191 1.218072113331234 22.465261727813196 -6.9450791399014 0.6104873774664562 0.9980750712506198 1.2729989289783137 0.9987562912731006 0.003321019957255315 0.08552403427537969 0.04461907902776905 0.0033741856803653388 0.014687013281001627 1.1348040056296583e-07 6.9450791399014 0.2749238577276939 GENLVSMTVEGPPPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GENLVSMTVEGPPPK 15 0 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 6523300.0 4071800.0 0.0 2451500.0 False True 3385882.1113249534 0.0 2964097.3155446877 1.0 0.0 0.8754283870754099 21.69110031208883 -9.081223831217972 11.700652148430914 0.9999818899151006 0.43771419319149146 0.3548645590876951 0.3573921426000726 0.0 0.0 0.34604345401973435 0.1153478180065781 8.29423180570535e-10 9.081223831217972 -0.5622676967236091 GENLVSMTVEGPPPK(ub)DTGIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GENLVSMTVEGPPPKDTGIAR 21 1 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 1 16213100.0 5739600.0 4353700.0 6119800.0 True False 5557399.539698197 6092155.11424556 4516840.789935334 1.0 1.096224065001525 0.8127615726870392 22.40597853342409 -6.815140115997361 1.3930387557090589 1.052131893831359 0.8072084913175558 0.8727693968990582 0.04198097543460464 0.19987900754121116 0.7634662330430918 0.023690832298171746 0.05467976652726585 1.5305935681314016e-07 6.815140115997361 -0.2449234025138033 GENLVSMTVEGPPPK(ub)DTGIAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GENLVSMTVEGPPPKDTGIAR 21 1 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 1 32509400.0 9876600.0 9769800.0 12863000.0 True False 12785453.396891968 9226102.041655576 10522065.985525543 1.0 0.7216092973205284 0.8229716740497732 23.607999986453155 -10.348532527935754 4.937822554157626 1.0001382134794135 0.7722904856850827 0.8706163737179288 0.04138101701730373 6.300152433100639e-05 8.312037989023522e-06 0.0400912170060325 0.013355665813061628 4.4819547964204526e-11 10.348532527935754 -0.2278477277943307 GENMSK(ub)ILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GENMSKILK 9 1 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 1 4328700.0 1346200.0 1226000.0 1756500.0 True False 1764881.2366193463 1043085.57891057 1574754.2295377492 1.0 0.5910230996101553 0.8922720673002406 20.751139673440964 -10.368396665464973 5.611643921298812 1.000073769342531 0.7416475834552154 0.4951144482570924 0.1229843760634862 0.00011353893988154212 1.2779026814751976e-05 0.11911300339383636 0.03969303669479857 4.281572817380908e-11 10.368396665464973 -0.2584261858873156 GENMSK(ub)ILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GENMSKILK 9 1 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 1 8093300.0 1242800.0 2263400.0 4587100.0 True False 1203347.9942743261 3167187.4234750685 3385600.899949732 1.0 2.631979642252221 2.813484475030354 20.19862248283847 -10.428172563073398 0.45209544874251256 4.611369315831626e-18 2.8166239840786003 0.9994159533001488 0.019707683947107087 1.8320254093325066 0.21269353763582666 2.209798453825826 0.04061417196391778 3.7310187960536496e-11 10.428172563073398 2.8166239840786003 GENMSK(ub)ILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GENMSKILK 9 1 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 1 14159600.0 3448200.0 2616800.0 8094600.0 True False 5231171.49718707 2149811.5948482817 6494698.762010777 1.0 0.4109617885791526 1.2415381077647976 22.318702637005085 -6.7162258062690645 1.7730890376192174 0.6401999158532404 1.239962192750781 0.494602567819341 0.2479903489656563 0.3626815958198246 2.2262744342122187 0.1111489334061809 0.2802512761387269 1.9220921000512796e-07 6.7162258062690645 0.5997622768975405 GENMSK(ub)ILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GENMSKILK 9 1 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 1 4454900.0 1346200.0 906200.0 2202500.0 True False 1843926.5196870966 866161.0875973362 1682314.8619113641 1.0 0.4697373123872195 0.9123546106364602 20.814349734963855 -10.092213973442185 7.435644728392474 1.0000000549439017 0.6910459615118415 0.3938054657310164 0.18069775533998636 1.6455520842396534e-07 2.033611609901241e-08 0.17495987796020762 0.05831994976073578 8.086973622405313e-11 10.092213973442185 -0.30895409343206015 GENMSK(ub)ILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GENMSKILK 9 1 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 1 8502400.0 3448200.0 1616100.0 3438100.0 True False 4463762.874183713 1526162.6143339248 2812401.0778850517 1.0 0.34190046768848886 0.6300516306882351 22.089828959097535 -10.446558344084721 6.1200039372401465 1.000210823122837 0.485976049188497 0.8092665383709007 0.11763721968982056 0.0003385250550722517 3.061335247475626e-05 0.1139474534405516 0.03796724939606817 3.576363516877038e-11 10.446558344084721 -0.51423477393434 GENSWFSTQVDTVATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GENSWFSTQVDTVATK 16 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 8101700.0 1152900.0 3760900.0 3187900.0 False True 1511463.064699482 3199788.379873379 2858046.6884960923 1.0 2.117013941395637 1.8909140125526958 20.527514293889556 -10.168083158454005 4.663211291859957 0.9998674701002896 2.003963976983457 0.9633552043540212 0.0923049094559349 0.0001271986187001278 2.2691912876398446e-05 0.08938545599020149 0.0297912814201717 6.790735915523848e-11 10.168083158454005 1.0040965068831673 GENSWFSTQVDTVATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GENSWFSTQVDTVATK 16 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 6043300.0 1152900.0 2643600.0 2246800.0 False True 1579158.2859510116 2526797.010783841 1716152.1142985043 1.0 1.600091031572643 1.0867511696365455 20.590724355412448 -10.229362482466366 4.290867529778483 0.9998305181010295 1.343421100615926 0.3737226467349132 0.20957012110047973 147747356.61420515 74.4039251224873 247402.6599350797 0.07174142668549947 5.897086762942849e-11 10.229362482466366 0.3435905825148965 GEPPLPEEDLSK(ub)LFKPPQPPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEPPLPEEDLSKLFKPPQPPAR 22 2 A0A087WZK9;B3KS98;O15372 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 13520600.0 4170000.0 4964100.0 4386500.0 True False 5466910.382337444 4223475.629910241 3932627.058279158 1.0 0.7725525634287866 0.7193509282655765 22.382294295324986 -13.999999999999998 0.2041033825318849 2.2845760392298367 0.686163486464611 0.9994875620767939 0.0027552239823634057 12.615089903641781 0.14323211545165265 6.480737729101904 0.03286824582530454 1.0000000000000041e-14 13.999999999999998 -1.5984125527652258 GEPPLPEEDLSK(ub)LFKPPQPPAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEPPLPEEDLSKLFKPPQPPAR 22 2 A0A087WZK9;B3KS98;O15372 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 41317000.0 10625000.0 10641000.0 20051000.0 True False 16118901.791547075 8742030.411487533 16087911.061334517 1.0 0.5423465273590753 0.9980773671424185 23.94225011813567 -10.915540389602228 10.939050974441088 1.027379118468053 0.7702119472521859 0.2531640364839617 0.18605133625321052 0.09428048788361794 0.0007279316839864316 0.13671190210970677 0.06004781057069337 1.2146736499662205e-11 10.915540389602228 -0.2571671712158671 GEPPLPEEDLSK(ub)LFKPPQPPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEPPLPEEDLSKLFKPPQPPAR 22 2 A0A087WZK9;B3KS98;O15372 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 15543600.0 4170000.0 6244700.0 5128900.0 True False 5711761.690012767 5968788.505538608 3917559.453011219 1.0 1.0449995692178933 0.685875858557128 22.445504356847877 -6.875484114556127 1.1046291634536334 1.0265272037011353 0.6625256755835749 0.969858787505805 0.02773384438763529 0.1317076885201598 0.29707290385860513 0.019412029944841928 0.04645140965567638 1.332035764075152e-07 6.875484114556127 -0.36400152811756037 GEPPLPEEDLSK(ub)LFKPPQPPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEPPLPEEDLSKLFKPPQPPAR 22 2 A0A087WZK9;B3KS98;O15372 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 41956000.0 10625000.0 12259000.0 19072000.0 True False 13754271.950061472 11576775.87347294 15601091.695245514 1.0 0.8416858351721918 1.1342724465452922 23.71337644022812 -6.759757585375657 1.6134383974895143 0.9080144994206416 1.13532658566881 0.6899603291186891 0.06658488005045092 0.28332275541633595 1.453578501909697 0.03256274414228282 0.07827041435135054 1.7387711057074413e-07 6.759757585375657 0.22731208624816834 GEQYDQAK(ub)LSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEQYDQAKLSR 11 1 A5YKK6-2;A5YKK6;A5YKK6-3;A5YKK6-4 A5YKK6-2 CNOT1 CCR4-NOT transcription complex subunit 1 1 6504150.0 451050.0 1314100.0 4739000.0 True False 583893.1165247281 1240969.1798132625 3876550.626246257 1.0 2.1253362039946344 6.639144248384171 19.15534477783613 -6.944811068851502 0.6131727449716327 0.9502797631468215 8.050549368143189 0.9987285709200544 0.08688829183662815 0.08563870781434935 0.04511836097611861 0.08805667473309763 0.3810456337451585 1.1355046868964414e-07 6.944811068851502 7.100269604996368 GERPDYK(ub)GEEELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GERPDYKGEEELR 13 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 20266700.0 7732800.0 5350200.0 7183700.0 True False 10137775.684541712 4551971.014916262 6440399.634916208 1.0 0.4490108241255723 0.6352872499178159 23.27323781153332 -10.060386903403874 5.60127616208521 1.0000024985709854 0.542149037021543 0.889565057410879 0.07604703238394019 2.372887237361345e-06 3.980425410134277e-07 0.07363262508479598 0.024544074162546496 8.701880131695618e-11 10.060386903403874 -0.4578534615494424 GERPDYK(ub)GEEELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GERPDYKGEEELR 13 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 35824000.0 6952200.0 8744800.0 20127000.0 True False 6731506.216441876 12236644.24352956 14855134.902942652 1.0 1.817816674318928 2.2068069797898433 22.682497922281712 -9.865395513957793 0.18389169931138774 3.9323682610196516e-20 2.6221586602162823 0.9995406223723962 0.010779519463357255 1.362180314059287 0.08180117446659294 0.9493871358172743 0.2585635948241039 1.3633409702358655e-10 9.865395513957793 2.6221586602162823 GERPDYK(ub)GEEELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GERPDYKGEEELR 13 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 19615100.0 7732800.0 5490000.0 6392300.0 True False 10591825.13106251 5247433.6469977675 4882570.39355098 1.0 0.49542298726294925 0.46097535912219023 23.336447873056212 -13.999999999999998 0.3812880420517401 8.547638904810157 0.4580169168028147 0.9998095872040377 0.0033998093899739188 24.198488324948663 0.20149994579052322 149.9976925990843 0.009300740753312163 1.0000000000000041e-14 13.999999999999998 -8.089621988007343 GERPDYK(ub)GEEELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GERPDYKGEEELR 13 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 28086700.0 6952200.0 13098000.0 8036500.0 True False 5781062.334680807 13027438.474250562 9716894.99342235 1.0 2.253467912999048 1.6808147760542793 22.46290319771599 -10.217341918539722 5.291603748173259 0.9999301875448479 1.967141344526837 0.791800218180342 0.23378466418720004 0.0001925791083771218 2.8483954868058583e-05 0.2263772039722968 0.07545367591620465 6.062588361691496e-11 10.217341918539722 0.9672111569819892 GERPDYK(ub)GEEELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GERPDYKGEEELR 13 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 20266900.0 5637700.0 12182000.0 2447200.0 True False 7298113.785681094 11504060.991161356 2001834.7103924516 1.0 1.5763060605786023 0.2742948067376057 22.799092213636282 -6.786347380023067 1.510672796193569 1.323618226681669 0.26175380659764297 0.789394267994316 0.24446975433745619 0.24080866460138403 1.085663200956901 0.12740196955055436 0.2991204185188312 1.6355078010947141e-07 6.786347380023067 -1.061864420084026 down GERPDYK(ub)GEEELRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GERPDYKGEEELRR 14 3 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 7100700.0 2350400.0 2197500.0 2552800.0 True False 3081397.1613059803 1869641.5657879098 2288660.744186715 1.0 0.6067512455926014 0.7427347480312204 21.555153212661878 -10.36726108541417 5.165469980062578 1.0001753205351889 0.6747429968118883 0.8841003879141568 0.05551503240193335 0.00011214684702380608 1.3737294407550185e-05 0.05378093610655822 0.017917399663059764 4.292782793604952e-11 10.36726108541417 -0.32543232372330055 GERPDYK(ub)GEEELRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GERPDYKGEEELRR 14 3 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 9817900.0 3652400.0 3605500.0 2560000.0 True False 5540957.826206741 2962070.355099922 2054014.8779121418 1.0 0.5345773146098303 0.3706967174876136 22.401703955648493 -13.999999999999998 0.14547193256618976 3.236310800684662 0.1806595937291905 0.9995820481693406 0.00544955609226583 11.943572853175697 0.11986784334806584 7.56187688645728 0.170591950139826 1.0000000000000041e-14 13.999999999999998 -3.0556512069554715 GERPDYK(ub)GEEELRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GERPDYKGEEELRR 14 3 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 7617800.0 2350400.0 2355500.0 2911900.0 True False 3219406.397171706 2251426.2214031424 2224169.192462975 1.0 0.6993296103844026 0.6908631337804818 21.61836327418477 GERPDYK(ub)GEEELRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GERPDYKGEEELRR 14 3 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 12539400.0 3652400.0 7322500.0 1564500.0 True False 4728103.799567491 6914996.438005175 1279777.0531256113 1.0 1.462530589670585 0.27067448333995553 22.172830277740943 -6.801482749965326 1.4499536366187449 1.2547203164269978 0.25363183717104504 0.8364350179380923 0.19842224106684925 0.21864839731299798 0.9073750958131982 0.10765196240817043 0.2501245587296121 1.5794913433718094e-07 6.801482749965326 -1.0010884792559527 down GESDPAYQQYQDAANNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GESDPAYQQYQDAANNLR 18 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 13086600.0 3873100.0 1943200.0 7270300.0 False True 3750150.5605277503 2719129.893654133 5365990.325675169 1.0 0.7250721937071978 1.4308733047027384 21.838517087217056 -6.801053524731027 1.4515015744135018 0.848514043565136 1.4408848635266323 0.8352668500411349 0.11789688870830019 0.21924869324990487 0.9118261864044724 0.06389422384801027 0.14850711161858102 1.5810531699726023e-07 6.801053524731027 0.5923708199614962 GESELDAK(ub)IPSTGDATEWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GESELDAKIPSTGDATEWR 19 1 P26010;P26010-2;F5H6T4;F8VNX4;F8W186;H3BRM2 P26010 ITGB7 Integrin beta-7;Integrin beta 1 39865600.0 2249100.0 4466500.0 33150000.0 True False 2948591.8803153806 3800115.610280641 29719955.99725385 1.0 1.2887899595905357 10.079372528854353 21.491594719634612 -6.913889150544046 0.8688386162689408 0.760150778196241 11.315205333754227 0.9923081838689303 0.36954873820930756 0.1019018358459198 0.12523531031342608 0.30849763630481675 0.8763775933633798 1.219300773912211e-07 6.913889150544046 10.555054555557986 up GESELDAK(ub)IPSTGDATEWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GESELDAKIPSTGDATEWR 19 1 P26010;P26010-2;F5H6T4;F8VNX4;F8W186;H3BRM2 P26010 ITGB7 Integrin beta-7;Integrin beta 1 54463810.0 2249100.0 6020200.0 46194510.0 True False 3080653.049642135 5754207.657860837 35284318.14379712 1.0 1.8678532003236379 11.453518969913192 21.554804781157504 -6.924626110425868 0.7896648417299794 0.8216274948161167 13.176642245567665 0.9953723010570652 0.3222142497942546 0.09552587366894745 0.09206739769854706 0.2846540070638365 0.8943308728607281 1.1895258644997724e-07 6.924626110425868 12.355014750751549 up GESENAGTNQETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GESENAGTNQETR 13 0 Q08170 Q08170 SRSF4 Serine/arginine-rich splicing factor 4 0 3568450.0 1150100.0 452350.0 1966000.0 False True 1113590.7050329112 632975.713974087 1451045.6212642358 1.0 0.5684096599525587 1.3030331653328153 20.086787643724307 -6.747541749524967 1.6594849222209287 0.7454645300020615 1.3041757057756322 0.6381017531301154 0.18133759084608034 0.30435268652759206 1.6483807620747575 0.08635980483676008 0.21015772782797315 1.788373601210175e-07 6.747541749524967 0.5587111757735708 GESLSSGK(ub)TETWNGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GESLSSGKTETWNGK 15 1 Q96B67 Q96B67 ARRDC3 Arrestin domain-containing protein 3 1 3865000.0 1089400.0 1397100.0 1378500.0 True False 1428213.9497646063 1188658.1258531474 1235866.0435057129 1.0 0.8322689510553081 0.8653227646385924 20.44578068394604 -10.282383714795833 5.553175338370535 1.0000156500104247 0.848795857846948 0.9653993609804251 0.013494162888700081 2.6148613920337164e-06 3.379243760575618e-07 0.01306701887378085 0.0043552223449102425 5.2193483701669904e-11 10.282383714795833 -0.1512197921634767 GESLSSGK(ub)TETWNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GESLSSGKTETWNGK 15 1 Q96B67 Q96B67 ARRDC3 Arrestin domain-containing protein 3 1 3166450.0 1089400.0 1111900.0 965150.0 True False 1492180.6199280347 1062772.5814384012 737201.4478881969 1.0 0.7122278410837805 0.49404303878692035 20.50899074546893 -7.383887973888448 0.1486650035131994 1.2899091147087796 5.860361797448922e-11 0.9999912416044221 0.0006131911519339095 0.11977824754410044 0.010551532292070627 0.03025888877083053 0.05568803975597167 4.131540611934501e-08 7.383887973888448 -1.289909114650176 down GESLSSGK(ub)TETWNGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GESLSSGKTETWNGK 15 1 Q96B67 Q96B67 ARRDC3 Arrestin domain-containing protein 3 1 2875330.0 970530.0 1289400.0 615400.0 True False 807038.6967690473 1282453.7462741397 744077.2947118907 1.0 1.5890858163411505 0.9219846553712723 19.62227832550906 -6.673531248994101 1.9243156608263032 1.3748417961415347 0.9245994894331713 0.2950890579973997 0.2500249539721517 0.45301516033228684 3.2372022833793412 0.1044631682013014 0.2778753101939092 2.1206487995648268e-07 6.673531248994101 -0.4502423067083634 GESLSSGK(ub)TETWNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GESLSSGKTETWNGK 15 1 Q96B67 Q96B67 ARRDC3 Arrestin domain-containing protein 3 1 6373300.0 2154600.0 1495900.0 2722800.0 True False 2789172.173515525 1412651.8499982161 2227278.338287257 1.0 0.506477105792176 0.798544585894084 21.411405562926785 -10.285129636914085 5.80212736048297 1.0000247270530773 0.6525108458431294 0.6536629082573366 0.11923604945170009 3.8141626992092664e-05 4.699466889445883e-06 0.115458011536674 0.03848326948283207 5.1864520021474676e-11 10.285129636914085 -0.347513881209948 GESPVDYDGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GESPVDYDGGR 11 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 22661540.0 459440.0 13213000.0 8989100.0 False True 602330.2892232897 11241671.903870597 8058994.161535874 1.0 18.663633732195063 13.379692679788723 19.200195283604266 -9.45800627262856 11.219900782741933 1.0000000293062625 16.021663205991892 0.9150817484728921 2.1571599015567133 0.0 0.0 2.0886611557058465 0.6962203644862983 3.483322839455812e-10 9.45800627262856 15.02166317668563 GESPVDYDGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GESPVDYDGGR 11 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 19881700.0 5102100.0 2137600.0 12642000.0 False True 4940136.628248347 2991154.827436738 9330680.948129442 1.0 0.6054801825384594 1.888749573195079 22.23611951197837 -6.824162435544309 1.3536453923588638 0.7881949633252031 1.9193725027500113 0.8937029904853051 0.17497744366820447 0.1881366527577747 0.6761957444487686 0.10154393757106808 0.23383811230355667 1.4991240257704064e-07 6.824162435544309 1.131177539424808 GESPVDYDGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GESPVDYDGGR 11 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 23697440.0 459440.0 10443000.0 12795000.0 False True 629307.383899153 9981593.72961706 9773084.521296674 1.0 15.861237266551155 15.529906006732665 19.263405345127158 -9.462273909604034 8.439045811882137 0.9999999493064107 15.695571636642661 0.9996188924302541 0.1352654204008813 0.0 0.0 0.13097018013135744 0.043656726710452474 3.4492612575208654e-10 9.462273909604034 14.695571687336251 GESQTDIEITR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GESQTDIEITR 11 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 3888450.0 701750.0 1685500.0 1501200.0 False True 920001.0457566674 1434029.9700275413 1345870.224527225 1.0 1.558726456498866 1.4629007550967463 19.811275975505485 -10.078206752997518 4.65055282324971 0.9999740208528298 1.5108136058108315 0.9742850079483335 0.03912067882575279 27172614.860639248 0.40045679966146897 7678.299394774099 0.013392048904234554 8.352053104107535e-11 10.078206752997518 0.5108395849580016 GESSGK(ub)NVTLPAVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GESSGKNVTLPAVFK 15 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 16158200.0 4612200.0 0.0 11546000.0 True False 4465788.235590636 0.0 8521756.22742465 1.0 0.0 1.9082311515600963 22.090483410563674 -6.764306115473863 1.5962123943864486 0.42226247048898063 1.9167374296735034 0.7083097065845922 0.4209046102666275 0.27574557029992025 1.38557494098208 0.20796002886559903 0.49766904407398316 1.7206553316255243e-07 6.764306115473863 1.4944749591845228 GESSGK(ub)NVTLPAVFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GESSGKNVTLPAVFK 15 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 18715200.0 4612200.0 5983500.0 8119500.0 True False 3835248.655104113 5951265.697868247 9817249.90967371 1.0 1.5517287751207598 2.559742742262224 21.87088868599795 -6.961774762755978 0.4096545236091367 0.9501570388360016 3.1987018601818393 0.9998304634199607 0.008408463766474404 0.07907313058063631 0.01883294931687177 0.012978803033206475 0.08417104783706378 1.0920065346911867e-07 6.961774762755978 2.248544821345838 GETHQGIGLFPSNFVTADLTAEPEMIK(ub)TEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GETHQGIGLFPSNFVTADLTAEPEMIKTEK 30 1 Q92783;Q92783-2;A6NMU3 Q92783 STAM Signal transducing adapter molecule 1 1 13888500.0 4605800.0 3679300.0 5603400.0 True False 4459591.4000874525 5148463.6772960285 4135701.4416032643 1.0 1.1544698191845708 0.9273722793353139 22.088480101875174 -6.723560053738897 1.7463383292767385 1.0936215900416453 0.9276507706362829 0.5292204351853184 0.06497533665739302 0.3485054306428495 2.0789356273076347 0.029519812949593743 0.07380195743979197 1.8899048792556923e-07 6.723560053738897 -0.1659708194053624 GETIEGALCK(ub)DGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GETIEGALCKDGR 13 1 Q6SJ93;Q6SJ93-2 Q6SJ93 FAM111B Protein FAM111B 1 10858500.0 1869700.0 0.0 8988800.0 True False 2836471.5933793476 0.0 7212159.740069009 1.0 0.0 2.542651848480705 21.435665985141235 -6.800020273895127 1.455881312537836 0.44826995355092675 2.577754113800543 0.8322183385248215 0.42840606618993604 0.22072139782453307 0.9236359673132437 0.23149538216656107 0.5383538932369386 1.584819207619666e-07 6.800020273895127 2.129484160249616 GETK(ub)SFYPEEVSSMVLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GETKSFYPEEVSSMVLTK 18 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 12059100.0 3158900.0 5024400.0 3875800.0 True False 4141348.490831116 4274779.104957802 3474769.3952988395 1.0 1.0322191224481831 0.8390429839439804 21.981669178658287 -6.8640299779014 1.1651296005934053 1.0177072753374479 0.8289387331888359 0.9583575798320291 0.017243470479833017 0.1427121312504612 0.3658624073881108 0.01152211064568269 0.027031585976854483 1.367634419089403e-07 6.8640299779014 -0.18876854214861194 GETK(ub)SFYPEEVSSMVLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GETKSFYPEEVSSMVLTK 18 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 63679700.0 8386700.0 18816000.0 36477000.0 True False 12723237.049898153 15458137.789920984 29267304.96156295 1.0 1.2149532174317794 2.3003033620125177 23.60096243245202 -6.939587857905235 0.6633967766537677 0.9877266731080402 2.589463248685545 0.9981092912330362 0.024746212728483954 0.08795535066765639 0.055471820265567934 0.024013876835624667 0.09358494347724854 1.1492437275474274e-07 6.939587857905235 1.6017365755775046 up GETK(ub)SFYPEEVSSMVLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GETKSFYPEEVSSMVLTK 18 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 63761700.0 8386700.0 17064000.0 38311000.0 True False 10856748.47657229 16114373.39953847 31338791.104055744 1.0 1.4842725180850949 2.886572455066222 23.37208875454447 -6.952244165437638 0.5336457374807658 0.97844655030678 3.456454886941168 0.9993657882390239 0.020147059167119608 0.08259706815421448 0.032329338503049566 0.022358089051311935 0.11601956384288327 1.1162355106758938e-07 6.952244165437638 2.478008336634388 GETTLWNPGCDHAGIATQVVVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GETTLWNPGCDHAGIATQVVVEK 23 0 P26640;A0A140T936;P26640-2 P26640 VARS Valine--tRNA ligase 0 10265300.0 1734600.0 2323900.0 6206800.0 False True 2375928.4958024337 2221222.413890366 4740881.673058554 1.0 0.9348860531007613 1.995380619170272 21.180059987826695 -6.892290820933041 1.0087661993471215 0.9461079448764704 2.0907826625012955 0.9823233545839163 0.06452275621781273 0.11730285419374849 0.21116417085662323 0.04858479788405041 0.12216152397758546 1.2814721703206592e-07 6.892290820933041 1.144674717624825 GEVPCTVTSASPLEEATLSELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEVPCTVTSASPLEEATLSELK 22 0 P48047;H7C068 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 7462800.0 3587500.0 1087000.0 2788300.0 False True 3473616.776198218 1521044.7686301144 2057960.582793015 1.0 0.4378850249263414 0.5924546993480952 21.728007168054404 -10.577910045932338 9.75357428168061 1.0000370428069192 0.5151698621373122 0.9291687009990176 0.0631028053402369 5.083363637106026e-05 2.1998673110337822e-06 0.06110365469433078 0.020366342848475494 2.6429561279294692e-11 10.577910045932338 -0.484867180669607 GEVQVSDK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEVQVSDKER 10 1 Q9Y3A5;A0A087X020 Q9Y3A5 SBDS Ribosome maturation protein SBDS 1 2345490.0 733970.0 1118800.0 492720.0 True False 1005338.5437934464 1069367.7166231512 376349.6838869326 1.0 1.063689165430884 0.37435119364552705 19.939249974416644 -6.88429872616631 1.0554978273434765 1.0422573692272579 0.32127809425015014 0.9769921225220575 0.0471787249142274 0.12389197114236651 0.24983464215480852 0.03428677391170599 0.08390081064596402 1.305272757312218e-07 6.88429872616631 -0.7209792749771078 down GEVQVSDK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GEVQVSDKER 10 1 Q9Y3A5;A0A087X020 Q9Y3A5 SBDS Ribosome maturation protein SBDS 1 2651690.0 1021500.0 487590.0 1142600.0 True False 1322351.8867753232 460455.18787394266 934658.5240660417 1.0 0.34820927203938506 0.7068152837481804 20.33467470816156 -10.683452857587973 6.8831297733724135 1.0031300802117424 0.5275122778939922 0.6983086966058119 0.14640029123017972 0.00706129074989604 0.00032474036615656477 0.1423398309884089 0.04725049081786681 2.0727510432849933e-11 10.683452857587973 -0.4756178023177502 GEVSPK(ub)LPEYICPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEVSPKLPEYICPR 14 1 Q9Y4L5 Q9Y4L5 RNF115 E3 ubiquitin-protein ligase RNF115 1 6697400.0 1468700.0 3448500.0 1780200.0 True False 1925479.9229110335 2933997.24214772 1596001.9808842011 1.0 1.5237745183610958 0.828885288230525 20.87678664947403 -6.705089585780551 1.8130382889797305 1.323611955832397 0.8307646480832047 0.44164225656030276 0.22089297513812 0.3850132905705983 2.4639053912136424 0.09707826995325572 0.2480736677907141 1.9720159089177293e-07 6.705089585780551 -0.4928473077491924 GEVSPK(ub)LPEYICPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEVSPKLPEYICPR 14 1 Q9Y4L5 Q9Y4L5 RNF115 E3 ubiquitin-protein ligase RNF115 1 7009200.0 1468700.0 2518500.0 3022000.0 True False 2011718.0801251212 2407224.3424342247 2308265.8400436556 1.0 1.1966012366327714 1.147410197705282 20.939996710996923 -10.105559034744575 4.379344426248833 0.9999791801392867 1.172005717181523 0.9422046660692556 0.02008215759051218 2211395.304157505 5102906.772194476 245.45814889905554 0.0068746567824472336 7.842255098842877e-11 10.105559034744575 0.17202653704223636 GEWK(ub)CER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEWKCER 7 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 1 7792650.0 545250.0 1018500.0 6228900.0 True False 714828.0302085117 866543.7700819054 5584393.179827888 1.0 1.212240893560286 7.81221908463627 19.44723668163371 -6.913747615253992 0.8698312352471289 0.8190685488155256 8.737213261412885 0.9922605169630586 0.2782163989980015 0.10199148853370717 0.12571284774777636 0.23208750575090595 0.6585833973053711 1.2196982051936096e-07 6.913747615253992 7.918144712597359 up GEWK(ub)CER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEWKCER 7 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 1 8570770.0 545250.0 656720.0 7368800.0 True False 746843.6598272094 627703.9389173731 5628441.205199757 1.0 0.8404756881280874 7.536304460965711 19.510446743156603 -6.901441847236194 0.9520918322363102 0.7325180920250326 8.260133003280252 0.987270532666767 0.351960065463625 0.11035226386434732 0.1714878591932622 0.2764804737039097 0.7247138529138493 1.2547527401185925e-07 6.901441847236194 7.5276149112552195 up GEWTCIAYSQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEWTCIAYSQLR 12 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 23031500.0 6289900.0 8340200.0 8401400.0 False True 8246119.81147825 7095874.66984497 7532103.71991941 1.0 0.8605107410600332 0.9134118703241542 22.975283992249132 -10.632872089584566 8.79690781837323 1.0000666249269121 0.8869613059828418 0.8589132532325069 0.02159679558568521 2.8236662106043287e-05 1.178401559947517e-06 0.020923294493949387 0.006970335802900397 2.328777038833017e-11 10.632872089584566 -0.11310531894407028 GEWTCIAYSQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEWTCIAYSQLR 12 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 19782200.0 6289900.0 7528700.0 5963600.0 False True 8615446.00815619 7196057.139918411 4555120.504197335 1.0 0.8352506803601285 0.5287155766381718 23.038494053772023 -6.961433133011679 0.4147486112189109 1.0143402944179212 0.338161800398813 0.9998196986749456 0.002622167047364857 0.07919318124972129 0.019269220733886438 0.003953987868187873 0.025555427246707632 1.0928658794408637e-07 6.961433133011679 -0.6761784940191082 GEWTCK(ub)PIAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEWTCKPIAEK 11 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 1 14195050.0 623340.0 1380610.0 12191100.0 True False 853805.64313011 1319610.0851332592 9311813.263585776 1.0 1.5455626180865685 10.906244692232333 19.703548172380668 -6.918867947920554 0.8330731046030796 0.7849138238462756 12.37715364827729 0.9938607494982642 0.35625057002208704 0.09884265081888828 0.10909745042954425 0.30512001316900894 0.9043276634431437 1.2054024006955238e-07 6.918867947920554 11.592239824431013 up GEYK(ub)MALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GEYKMALK 8 1 O60239;O60239-2;C9JK30 O60239 SH3BP5 SH3 domain-binding protein 5 1 7052000.0 1822300.0 2176700.0 3053000.0 True False 2389052.9471783 1851944.8447101456 2737104.846443919 1.0 0.7751794898047235 1.1456861388010264 21.188007397076184 -6.742428748469886 1.6776484786437587 0.8666127259161098 1.1460276643134482 0.6158779180772598 0.09445655907818457 0.31343146393023563 1.732987635478885 0.04452337149394602 0.10897300653338973 1.8095527660343338e-07 6.742428748469886 0.27941493839733833 GEYK(ub)MALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GEYKMALK 8 1 O60239;O60239-2;C9JK30 O60239 SH3BP5 SH3 domain-binding protein 5 1 10997400.0 1685200.0 5182300.0 4129900.0 True False 1631704.2484318444 7251619.415337491 3048155.2956557316 1.0 4.444199628889051 1.8680807496733387 20.637948157278885 -6.5719234700456 2.297733790844821 3.3565434858146546 1.8733815878035083 0.0 1.4992715916270474 0.7239152801910144 7.176535625921027 0.5505588397143493 1.680664833660959 2.6796404807058256e-07 6.5719234700456 -1.4831618980111463 GEYK(ub)MALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GEYKMALK 8 1 O60239;O60239-2;C9JK30 O60239 SH3BP5 SH3 domain-binding protein 5 1 21661500.0 4167800.0 14544000.0 2949700.0 True False 6322857.306993878 11948509.56720933 2366690.50210056 1.0 1.8897325982657824 0.37430711894805874 22.592145230744162 -6.747552907710805 1.6587012159164887 1.5246822821603694 0.37179626288914375 0.6385340612764436 0.37383415013791166 0.30429088518556213 1.6463631414756583 0.1780916640760216 0.4335090341478237 1.788327653703416e-07 6.747552907710805 -1.1528860192712256 GEYK(ub)MALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GEYKMALK 8 1 O60239;O60239-2;C9JK30 O60239 SH3BP5 SH3 domain-binding protein 5 1 6492100.0 1822300.0 1728600.0 2941200.0 True False 2496053.5558058154 1652224.7362842157 2246549.1359154186 1.0 0.6619348100288731 0.900040438110773 21.251217458599076 -10.07049540047085 5.647131182021171 1.000001234338425 0.7809876240697716 0.5300910336766775 0.09720621561444155 1.5107183928657481e-06 2.486055908670675e-07 0.09412004507689718 0.03137317118518856 8.501676971019713e-11 10.07049540047085 -0.2190136102686534 GEYK(ub)MALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GEYKMALK 8 1 O60239;O60239-2;C9JK30 O60239 SH3BP5 SH3 domain-binding protein 5 1 12467700.0 1685200.0 9110600.0 1671900.0 True False 1401318.4670182262 9061519.3894875 2021486.5600078166 1.0 6.466424016211613 1.4425604226205664 20.41835343271316 -6.626100338713324 2.094216846085793 4.611538872238702 1.4623210882269682 0.10369079488920074 2.3471260871743156 0.5692928658905763 4.752541980136982 0.9182026014396084 2.601399975044429 2.3653731422639327e-07 6.626100338713324 -3.149217784011734 GFAEHGK(ub)QQQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFAEHGKQQQGR 12 1 O15037;G3V3G3 O15037 KHNYN Protein KHNYN 1 77175000.0 15157000.0 39261000.0 22757000.0 True False 19870973.780596804 33403411.83817933 20402323.94055822 1.0 1.6810153446428682 1.026740016157651 24.244159238058025 -10.245419960658353 3.844879386989123 0.999557682344263 1.3538776804915602 0.2806031396634949 0.2671067846854643 190097403.005704 354908777.7281479 1017461.0462748808 0.09775105255947977 5.683031186934456e-11 10.245419960658353 0.3543199981472972 GFAEHGK(ub)QQQGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFAEHGKQQQGR 12 1 O15037;G3V3G3 O15037 KHNYN Protein KHNYN 1 53344180.0 16732000.0 23526180.0 13086000.0 True False 16200851.818633739 32920306.361407954 9658384.028414948 1.0 2.032010830661632 0.5961651977648583 23.949566334248026 -6.713816806398284 1.781321002538255 1.6319890393243164 0.5991154886352326 0.48318901062579156 0.4346384544658948 0.36753148942206726 2.275548444715001 0.19398884076144324 0.4906066709311642 1.9327834295859334e-07 6.713816806398284 -1.0328735506890838 GFAEHGK(ub)QQQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFAEHGKQQQGR 12 1 O15037;G3V3G3 O15037 KHNYN Protein KHNYN 1 60764000.0 15157000.0 23095000.0 22512000.0 True False 20760952.502523627 22074586.535047986 17195129.249193486 1.0 1.0632742660706285 0.8282437545725952 24.307369299580916 -6.835048251558248 1.3053121067692712 1.0337094761841692 0.8212467130871635 0.9155766983389688 0.028852098216308082 0.1746658905222954 0.5802392404225524 0.017345494519780222 0.03992053300876595 1.4620147307442428e-07 6.835048251558248 -0.21246276309700574 GFAEHGK(ub)QQQGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFAEHGKQQQGR 12 1 O15037;G3V3G3 O15037 KHNYN Protein KHNYN 1 41374600.0 16732000.0 15129000.0 9513600.0 True False 13913399.35328087 15047497.07412864 11502849.77408359 1.0 1.0815111887506013 0.8267461805709719 23.729971609682302 -6.8206448969392 1.3692943163908933 1.0439048433572775 0.8211168235717886 0.8858114442145326 0.035897529960542525 0.19264828781882262 0.7096136905792771 0.020601391289205084 0.04746994477524887 1.5113153837011512e-07 6.8206448969392 -0.2227880197854889 GFAFISFHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFAFISFHR 9 0 O75821;K7ENA8;K7EP16 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 293312000.0 106380000.0 120430000.0 66502000.0 False True 139465210.18538544 102462313.43246327 59621010.972228505 1.0 0.7346800918757035 0.4274973729504062 27.055330043500167 -6.969203445102887 0.27655277617140944 1.0705449732780037 0.0823158440448896 0.9999754841561662 0.0011582613468683362 0.07656204809811135 0.009951862413372823 0.0057891116776890685 0.02832031389871637 1.0734864201874042e-07 6.969203445102887 -0.9882291292331141 down GFAFISFHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFAFISFHR 9 0 O75821;K7ENA8;K7EP16 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 316035000.0 133870000.0 83462000.0 98703000.0 False True 129620370.12673329 116788811.84858026 72849723.2734709 1.0 0.9010066221412014 0.5620237251463159 26.94971721784238 -6.948445275839783 0.5756585293144789 1.0041213923443777 0.44226687590797814 0.9990735647188093 0.005708146230516204 0.08411610634188772 0.0385927668049578 0.0060091177845706875 0.028284416128352464 1.1260423492141114e-07 6.948445275839783 -0.5618545164363995 GFAFISFHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFAFISFHR 9 0 O75821;K7ENA8;K7EP16 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 812770000.0 227210000.0 211200000.0 374360000.0 False True 344694181.27599174 173509709.88686845 300367581.9121834 1.0 0.5033729007103305 0.8714031110135954 28.360741704119356 -10.300783347878125 5.918307018486986 1.0000227418459022 0.6873880058619642 0.4903206062742028 0.15024770419536695 4.508836235519471e-05 5.3272536948911004e-06 0.14548728133685473 0.04849223801287907 5.0028404440814846e-11 10.300783347878125 -0.312634735983938 GFAFISFHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFAFISFHR 9 0 O75821;K7ENA8;K7EP16 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 393740000.0 106380000.0 126420000.0 160940000.0 False True 145711560.8114048 120834346.38496503 122929286.66334395 1.0 0.8292708259529354 0.8436481359392749 27.118540105023058 -10.471680951753951 6.044221793289233 1.0001047967626082 0.8364594809461051 0.9942369008553212 0.005869512223392201 8.294101689734465e-06 7.249842203367478e-07 0.005686760435780884 0.001894376924296563 3.375351830064009e-11 10.471680951753951 -0.1636453158165031 GFAFISFHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFAFISFHR 9 0 O75821;K7ENA8;K7EP16 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 267707000.0 133870000.0 59118000.0 74719000.0 False True 111318836.44655226 58799519.59999572 90342397.43837793 1.0 0.5282081764143057 0.8115643346825154 26.730122493276657 -10.2792315841708 5.9578001850729025 1.0000167675421043 0.6698862555484104 0.6440869763660194 0.11567966720540795 2.576532231771051e-05 3.1171665087361653e-06 0.11201204004711296 0.037335452048446245 5.2573684652756785e-11 10.2792315841708 -0.3301305119936939 GFAFISFHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFAFISFHR 9 0 O75821;K7ENA8;K7EP16 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 1051890000.0 227210000.0 507080000.0 317600000.0 False True 294127823.97867936 478860552.2408561 259800058.8511944 1.0 1.6280695439257988 0.8832896369233899 28.131868026211805 -6.683156738073937 1.8906638604646289 1.3962673026195518 0.8860569410536584 0.3385275904503695 0.2660114595346334 0.4316118305211987 2.9855865460728404 0.11278471053877967 0.2962653913189007 2.074164810568466e-07 6.683156738073937 -0.5102103615658934 GFAFISFHRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFAFISFHRR 10 1 O75821;K7ENA8;K7EP16 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 12544500.0 6125900.0 1023000.0 5395600.0 False True 8031114.223299993 870372.3876227681 4837315.07024986 1.0 0.10837504777327536 0.6023217869589959 22.937168728039907 -10.253915927031093 5.350461804746634 1.0000656796329632 0.3553484178745437 0.6942886961338501 0.20165291185299952 0.00015800544603226255 2.2032787137912293e-05 0.1952693576136936 0.06508319744337508 5.57293622268035e-11 10.253915927031093 -0.6447172617584196 GFAFITFMFPEHAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFAFITFMFPEHAVK 15 0 Q9Y4C8 Q9Y4C8 RBM19 Probable RNA-binding protein 19 0 7013500.0 2198100.0 1784500.0 3030900.0 False True 2845483.781028721 1685191.0062984272 2479307.299660216 1.0 0.5922335658821377 0.8713131019020878 21.440242525601565 -10.06544381513421 5.441387115266818 1.000002204042521 0.7317733338919331 0.55190068562166 0.11393374348422443 3.0464401871996037e-06 5.233941629952984e-07 0.11031677926512898 0.036771957590364265 8.601143330563444e-11 10.06544381513421 -0.26822887015058783 GFAFVEFSHLQDATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFAFVEFSHLQDATR 15 0 P98175-4;P98175-3;P98175-2;P98175;P98175-5 P98175-4 RBM10 RNA-binding protein 10 0 6367500.0 1580700.0 2634800.0 2152000.0 False True 2072313.0075205737 2241698.110369959 1929331.683441638 1.0 1.0817372193460517 0.9310039923698562 20.98281049720023 -6.759408157475798 1.614442694722352 1.047511094856454 0.9304641944913766 0.6886730256895082 0.0343762343860678 0.28389873027615103 1.4582155124835103 0.016800552418519875 0.04040211722854277 1.7401706621152887e-07 6.759408157475798 -0.11704690036507748 GFAFVEFSHLQDATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFAFVEFSHLQDATR 15 0 P98175-4;P98175-3;P98175-2;P98175;P98175-5 P98175-4 RBM10 RNA-binding protein 10 0 8758900.0 3201500.0 1623700.0 3933700.0 False True 3099870.1349124997 2272051.87748364 2903345.9615295683 1.0 0.7329506652212621 0.9366024495124604 21.563776346229435 -10.525646407038304 5.33612617547956 1.0004862515997435 0.8347765573668606 0.4674103654704552 0.08314049278679939 0.0004823500938844764 4.287818503481479e-05 0.08073448329175181 0.026833478663228973 2.980942459104798e-11 10.525646407038304 -0.16570969423288284 GFAFVEFSHLQDATR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFAFVEFSHLQDATR 15 0 P98175-4;P98175-3;P98175-2;P98175;P98175-5 P98175-4 RBM10 RNA-binding protein 10 0 19683100.0 3182700.0 9393000.0 7107400.0 False True 4828388.586537124 7716745.762156024 5702619.27471591 1.0 1.5982031321324126 1.1810605489824042 22.203110357536115 -10.325658253566385 4.948290089495239 0.9998206027191792 1.3896318405575512 0.5377357278086365 0.1702977464511648 0.0003371938380414867 4.5952239658858924e-05 0.16496530492684497 0.054963361325097305 4.7243465397766005e-11 10.325658253566385 0.389811237838372 GFAFVEFSHLQDATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFAFVEFSHLQDATR 15 0 P98175-4;P98175-3;P98175-2;P98175;P98175-5 P98175-4 RBM10 RNA-binding protein 10 0 5391700.0 3201500.0 1118400.0 1071800.0 False True 2662189.1004977725 1112374.9572149813 1295908.424556719 1.0 0.4178422024968065 0.48678301038585564 21.34418162166371 -10.385831475449395 5.8881865171596 1.0001324933005913 0.45231260644246946 0.9882559479836605 0.028144966963903915 4.896455298627422e-05 5.107267081916245e-06 0.02725775079706275 0.009083749027562857 4.113092954719111e-11 10.385831475449395 -0.5478198868581219 GFAFVEFSHLQDATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFAFVEFSHLQDATR 15 0 P98175-4;P98175-3;P98175-2;P98175;P98175-5 P98175-4 RBM10 RNA-binding protein 10 0 14683400.0 3182700.0 7658800.0 3841900.0 False True 4120067.890396301 7232581.047373721 3142713.621222934 1.0 1.7554519099630743 0.7627819989443531 21.974236679628564 -6.703256749181973 1.8192930294472187 1.46759729186591 0.7655486571286517 0.43305876798812815 0.31869892271629213 0.3887702171714433 2.5038522545859103 0.13963633559197494 0.3576661816547243 1.980355919311703e-07 6.703256749181973 -0.7020486347372582 GFAFVQYVNER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFAFVQYVNER 11 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;G3V4M8;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 419950000.0 131960000.0 140750000.0 147240000.0 False True 173000837.90245798 119750648.63920303 132005017.22581173 1.0 0.6921969285878332 0.7630310860126546 27.366203784445254 -9.948222877871215 5.450138606107962 1.0000005044912892 0.7276140072994823 0.9517285545009332 0.02891792367781079 1.7728060180332448e-07 3.421956228845983e-08 0.027999711353941466 0.009333219733866768 1.1266191321888713e-10 9.948222877871215 -0.27238649719180685 GFAFVQYVNER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFAFVQYVNER 11 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;G3V4M8;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 310533000.0 111070000.0 49783000.0 149680000.0 False True 107544143.64664431 69661611.51491538 110474317.69625165 1.0 0.6477490001110723 1.0272462446605641 26.680353723543885 -11.844014544485203 13.525952633059406 0.900770636001464 0.8537478606195246 0.0 0.17694340721347987 0.0 0.0 0.0 0.051443066290811384 1.4321399362259427e-12 11.844014544485203 -0.04702277538193944 GFAFVQYVNER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFAFVQYVNER 11 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;G3V4M8;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 441003000.0 84103000.0 195930000.0 160970000.0 False True 127590399.75289279 160964760.691923 129154208.9443428 1.0 1.2615742328863855 1.0122564800680824 26.926944540004627 -10.65396903159247 2.8738822354205884 0.9861348132079989 1.136915356532134 0.28678530301218186 0.10178354783029912 25108990.662167534 20022405.698683858 2521324.993731181 0.03724896475156075 2.218354599244868e-11 10.65396903159247 0.15078054332413504 GFAFVQYVNER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFAFVQYVNER 11 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;G3V4M8;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 433430000.0 131960000.0 113710000.0 187760000.0 False True 180749178.08491257 108685916.21131435 143414955.03858274 1.0 0.6013079415512238 0.7934473426551854 27.429413845968146 -10.121922951950113 4.883446965459534 1.0000155904291905 0.6973776421016511 0.7678500778902555 0.07844058203680754 1.3315235480388382e-05 2.394110057700654e-06 0.07595367713780285 0.025316588990516378 7.552262002279707e-11 10.121922951950113 -0.30263794832753943 GFAFVQYVNER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFAFVQYVNER 11 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;G3V4M8;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 227611000.0 111070000.0 54456000.0 62085000.0 False True 92359626.2352922 54162634.71933034 75066686.45139383 1.0 0.5864319392257769 0.8127651606141901 26.46075899897816 -10.119221995203336 5.180675286159057 1.000008216316923 0.6995985499196145 0.7013856368370438 0.09240015070828593 8.768974270455417e-06 1.4909285237276132e-06 0.08946850737927396 0.029822020406502076 7.599377257115709e-11 10.119221995203336 -0.3004096663973086 GFAFVQYVNER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFAFVQYVNER 11 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;G3V4M8;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 483863000.0 84103000.0 244550000.0 155210000.0 False True 108872991.41797854 230940577.5232731 126963372.58908644 1.0 2.1211925429389566 1.1661604125641816 26.698070862097076 -6.607067220412323 2.1647563307924815 1.7505607378402273 1.1695057630611747 0.04126602998645312 0.48374883997637363 0.6208370885593282 5.508843085869914 0.18482258120353046 0.5372615617855113 2.4713415993810145e-07 6.607067220412323 -0.5810549747790525 GFAFVTFDDHDSVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFAFVTFDDHDSVDK 15 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 367223000.0 120939000.0 117344000.0 128940000.0 False True 158552200.17494193 99836732.60332952 115598525.67981628 1.0 0.6296773711949285 0.7290881208350827 27.24038265646783 -10.080905457728665 7.258113569084703 1.0000000684060195 0.6793827460150069 0.9327460772625168 0.04058426859432412 4.4928760026327314e-08 5.727937163240612e-09 0.0392955572935958 0.013098516365318823 8.300314387407988e-11 10.080905457728665 -0.3206173223910126 GFAFVTFDDHDSVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFAFVTFDDHDSVDK 15 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 382630300.0 133753300.0 68325000.0 180552000.0 False True 129507374.70435491 95607528.81016794 133260014.75610386 1.0 0.73824003481211 1.0289762653309562 26.948459012581903 -6.669529387736305 1.9393954192688794 0.8328455965139454 1.0277884745103465 0.2767641768042183 0.11120325563828595 0.46222885475084385 3.3514384068351735 0.046172377400533086 0.1234208521014566 2.1402800939041379e-07 6.669529387736305 0.1949428779964011 GFAFVTFDDHDSVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFAFVTFDDHDSVDK 15 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 437255000.0 69652000.0 282230000.0 85373000.0 False True 105667176.24327873 231863851.42694524 68498989.1296849 1.0 2.1942845419955437 0.6482522914398593 26.65495205611036 -6.700435670576639 1.8290340257042197 1.7413138077883135 0.6527873305535467 0.41959483379718565 0.5040883902739766 0.3947143990349306 2.5674086171291046 0.21982966706541907 0.5650992156816868 1.9932617341428526e-07 6.700435670576639 -1.0885264772347667 GFAFVTFDDHDSVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFAFVTFDDHDSVDK 15 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 382309100.0 120939000.0 118449000.0 142921100.0 False True 165653416.553586 113215531.5215372 109166079.73244974 1.0 0.683448213003889 0.6590028868926854 27.30359271799072 -13.9999999999952 0.3631853171940549 5.224969329773713 0.6561923714397923 0.9997790054566104 0.002308764887409207 22.044583154078058 0.19502357635806314 72.29431526789007 0.006981384729569106 1.0000000000110518e-14 13.9999999999952 -4.56877695833392 GFAFVTFDDHDSVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFAFVTFDDHDSVDK 15 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 261854300.0 133753300.0 65416000.0 62685000.0 False True 111221795.22586566 65063591.02394062 75792143.67730719 1.0 0.584989577733497 0.6814504614261164 26.72886428801618 -10.022987955530494 5.972653389490961 1.000000535859956 0.6332200195797719 0.9506839093050167 0.039379990864269174 2.809987192991439e-07 4.594755952007555e-08 0.03812956787670682 0.012709837399241445 9.484447665493597e-11 10.022987955530494 -0.36678051628018404 GFAFVTFDDHDSVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFAFVTFDDHDSVDK 15 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 305221000.0 69652000.0 163190000.0 72379000.0 False True 90165887.04618177 154108333.0444608 59206764.67125507 1.0 1.7091644977166205 0.6566426240661299 26.42607837820281 -6.725195868304236 1.7407158013341728 1.4290366695329615 0.657793139210633 0.5368828218955566 0.2982447515749564 0.34531281323221963 2.047522112957595 0.13590269938956206 0.33908699898794364 1.8827997488175307e-07 6.725195868304236 -0.7712435303223285 GFAFVTFDDHDSVDKIVIQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFAFVTFDDHDSVDKIVIQK 20 1 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 61573900.0 7750900.0 27965000.0 25858000.0 False True 11758681.966691969 22974427.258457735 20747154.96603599 1.0 1.9538267404064382 1.7644116087844763 23.48722302143648 -10.202921090603922 4.569906023467205 0.9998043509682797 1.8591191746042726 0.9648251387703852 0.07732840370270978 54375762.13097879 40.18151867502088 111945.41680057198 0.02647156939791007 6.26727727997804e-11 10.202921090603922 0.8593148236359929 GFAFVTFDDHDSVDKIVIQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFAFVTFDDHDSVDKIVIQK 20 1 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 40114900.0 7750900.0 21999000.0 10365000.0 False True 10033692.843080604 20774736.31132484 8478676.353881074 1.0 2.0704975362736393 0.8450205210066906 23.25834934352893 -6.675883320434534 1.9167089491283986 1.6798059073961433 0.8498428976384602 0.30533304456329136 0.4541164267747624 0.4477150915702544 3.17642275583642 0.190372807276697 0.504723126955858 2.1091947398389164e-07 6.675883320434534 -0.8299630097576831 GFAFVTFDDHDTVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFAFVTFDDHDTVDK 15 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 103055000.0 31830000.0 35180000.0 36045000.0 False True 41729438.24215847 29931281.13056597 32315409.168054733 1.0 0.7172701668513466 0.7744031678674044 25.314562163516243 -10.728186010190413 6.854355976243349 1.0034833976184905 0.7458366673593777 0.9634863590198519 0.02332444999387574 0.0012548343014099103 4.976121999106345e-05 0.02282445671518007 0.007527933865477365 1.8698810907356242e-11 10.728186010190413 -0.2576467302591128 GFAFVTFDDHDTVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFAFVTFDDHDTVDK 15 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 124238800.0 43265000.0 18566800.0 62407000.0 False True 41891576.25706369 25980620.064582918 46060734.53013079 1.0 0.6201872162831807 1.0995225925012575 25.32015683381739 -6.695554458224295 1.847009415532447 0.7631312143545694 1.0979719373996462 0.39644597371884893 0.16045747759931703 0.4048070349018927 2.6816527993207275 0.06939472761904368 0.17943181467539832 2.0157911852939433e-07 6.695554458224295 0.3348407230450767 GFAFVTFDDHDTVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFAFVTFDDHDTVDK 15 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 138849000.0 19874000.0 92564000.0 26411000.0 False True 30150310.984019466 76045230.99416706 21190854.273647465 1.0 2.5222038682942016 0.7028403217757597 24.84566954702641 -6.68474754344587 1.8846420201342418 1.9590200878397044 0.7094459734290266 0.3459215343832934 0.6444963901163075 0.4281942748963829 2.9443220695331958 0.2739707981566497 0.7183140828966389 2.0665811158946945e-07 6.68474754344587 -1.2495741144106778 GFAFVTFDDHDTVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFAFVTFDDHDTVDK 15 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 110496000.0 31830000.0 32806000.0 45860000.0 False True 43598411.173406795 31356522.445065375 35028812.51634746 1.0 0.7192125034178204 0.8034424093351725 25.377772225039134 -10.234360301275778 7.659336481325819 1.0000003262198516 0.7613274563764966 0.9145708043998526 0.03438671509669103 1.915816301020742e-07 1.910858364279108e-08 0.03329483936806369 0.01109826457502197 5.829612647406179e-11 10.234360301275778 -0.238672869843355 GFAFVTFDDHDTVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFAFVTFDDHDTVDK 15 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 76163000.0 43265000.0 19301000.0 13597000.0 False True 35976764.46448109 19197021.682051443 16440069.834575186 1.0 0.533595001323817 0.45696354520168236 25.100562109251666 -13.999999999999998 0.25414790807548526 4.3126629417592115 0.42734455486552836 0.9995506387022173 0.005087033970707808 14.166323625718746 0.1595220507226556 24.017094877203025 0.034567845713317745 1.0000000000000041e-14 13.999999999999998 -3.885318386893683 GFAFVTFDDHDTVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFAFVTFDDHDTVDK 15 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 92628000.0 19874000.0 47875000.0 24879000.0 False True 25727284.775107946 45210714.16449273 20351277.28009721 1.0 1.7573060880577527 0.79103867578703 24.61679586911886 -6.697664328338128 1.8392437590907227 1.4713336101640686 0.7940416542792059 0.4064592029631331 0.31980771643343214 0.40041256857005736 2.6317356394003637 0.1388060112636479 0.3579993328397585 2.006021907864735e-07 6.697664328338128 -0.6772919558848627 GFAFVTFESPADAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFAFVTFESPADAK 14 0 P38159;H3BT71;H0Y6E7;Q96E39;H3BR27;P38159-3;A0A1B0GUK8;O75526;Q8N7X1 P38159 RBMX;RBMXL1;RBMXL2;RBMXL3 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1;RNA-binding motif protein, X-linked-like-2;RNA-binding motif protein, X-linked-like-3 0 64751000.0 19011000.0 21086000.0 24654000.0 False True 24923605.10278591 17940050.99258425 22103040.577867143 1.0 0.719801606493073 0.886831599470195 24.571009427907967 -10.279741273052265 5.353183567465698 1.0000274213879152 0.8033166033625599 0.6489725293450384 0.0681897090891513 2.231947447606078e-05 3.0029813458234544e-06 0.06603359966034901 0.0220081339737437 5.251202026202635e-11 10.279741273052265 -0.19671081802535528 GFAFVTFESPADAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFAFVTFESPADAK 14 0 P38159;H3BT71;H0Y6E7;Q96E39;H3BR27;P38159-3;A0A1B0GUK8;O75526;Q8N7X1 P38159 RBMX;RBMXL1;RBMXL2;RBMXL3 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1;RNA-binding motif protein, X-linked-like-2;RNA-binding motif protein, X-linked-like-3 0 53637400.0 20238000.0 9150400.0 24249000.0 False True 19595555.767721135 12804202.43870563 17897459.445593312 1.0 0.6534237962159465 0.9133427833200312 24.224023155343275 -10.306558141434168 5.558544493418185 1.000030280603845 0.783383289767985 0.4808096911488938 0.1061114821443548 3.9824572579979026e-05 4.968169112212701e-06 0.10275634735254024 0.03424733359887072 4.936758226787185e-11 10.306558141434168 -0.21664699083586003 GFAFVTFESPADAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFAFVTFESPADAK 14 0 P38159;H3BT71;H0Y6E7;Q96E39;H3BR27;P38159-3;A0A1B0GUK8;O75526;Q8N7X1 P38159 RBMX;RBMXL1;RBMXL2;RBMXL3 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1;RNA-binding motif protein, X-linked-like-2;RNA-binding motif protein, X-linked-like-3 0 84513000.0 17464000.0 45419000.0 21630000.0 False True 26494164.789419115 37313624.58973326 17354821.019234203 1.0 1.4083714239082212 0.655043144676338 24.659171312326674 -6.759485188385212 1.6143283568008397 1.2373603204839128 0.6523554731543244 0.6888614521643771 0.1717504416396688 0.2838002266152913 1.457550032582938 0.0839464824643832 0.20184572071351162 1.739862035027082e-07 6.759485188385212 -0.5850048473295884 GFAFVTFESPADAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFAFVTFESPADAK 14 0 P38159;H3BT71;H0Y6E7;Q96E39;H3BR27;P38159-3;A0A1B0GUK8;O75526;Q8N7X1 P38159 RBMX;RBMXL1;RBMXL2;RBMXL3 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1;RNA-binding motif protein, X-linked-like-2;RNA-binding motif protein, X-linked-like-3 0 63227000.0 19011000.0 20195000.0 24021000.0 False True 26039880.452957503 19302718.124065567 18347734.52802401 1.0 0.7412752204810235 0.7046013349089761 24.63421948943086 -13.999999999999998 0.2752084262303868 3.0539672209082336 0.6930294653330451 0.999594628273244 0.002646859395202832 15.145155544674433 0.16612194612690778 17.458711031749708 0.014845320221040303 1.0000000000000041e-14 13.999999999999998 -2.3609377555751885 GFAFVTFESPADAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFAFVTFESPADAK 14 0 P38159;H3BT71;H0Y6E7;Q96E39;H3BR27;P38159-3;A0A1B0GUK8;O75526;Q8N7X1 P38159 RBMX;RBMXL1;RBMXL2;RBMXL3 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1;RNA-binding motif protein, X-linked-like-2;RNA-binding motif protein, X-linked-like-3 0 40580700.0 20238000.0 9401700.0 10941000.0 False True 16828793.695415888 9351051.17600866 13228712.514531681 1.0 0.5556578412721203 0.7860760999248058 24.00442843077755 -10.0981056200409 4.9339433197991385 1.0000116808823778 0.670866970596736 0.7312185413771835 0.09406786019259462 130934157.5718036 4.922176877276498 17375.458060858175 0.03220193060142386 7.978006392500435e-11 10.0981056200409 -0.32914471028564185 GFAFVTFESPADAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFAFVTFESPADAK 14 0 P38159;H3BT71;H0Y6E7;Q96E39;H3BR27;P38159-3;A0A1B0GUK8;O75526;Q8N7X1 P38159 RBMX;RBMXL1;RBMXL2;RBMXL3 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1;RNA-binding motif protein, X-linked-like-2;RNA-binding motif protein, X-linked-like-3 0 65899000.0 17464000.0 30421000.0 18014000.0 False True 22607492.266905744 28728044.607791837 14735636.839248788 1.0 1.2707311482682995 0.6518032458124394 24.430297634419123 -6.787816623232047 1.5051244826384007 1.1517409936580183 0.6456174006603743 0.7941575821707444 0.11493778223410658 0.23861658873730385 1.0679410371675757 0.06011657843676548 0.14096997693320867 1.629984132855852e-07 6.787816623232047 -0.506123592997644 GFAFVYFENVDDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFAFVYFENVDDAK 14 0 P62995-3;P62995;H7BXF3 P62995-3 TRA2B Transformer-2 protein homolog beta 0 11378900.0 3400700.0 4922200.0 3056000.0 False True 4458350.632425643 4187826.9465853255 2739794.435221951 1.0 0.9393220255327621 0.6145309467800469 22.088078652895664 -6.938297152306148 0.6752227867624208 1.0037754203768574 0.531166048640645 0.9979321922922498 0.007695543785927738 0.08855228699517707 0.05821296095398274 0.007397674508366616 0.0281703288954668 1.1526643137330883e-07 6.938297152306148 -0.4726093717362124 GFAFVYFENVDDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFAFVYFENVDDAK 14 0 P62995-3;P62995;H7BXF3 P62995-3 TRA2B Transformer-2 protein homolog beta 0 36876100.0 14427000.0 8643100.0 13806000.0 False True 13969022.781940546 12094334.903171072 10189794.428877955 1.0 0.8657967770520705 0.7294564972756392 23.735727763200853 -6.970928432697402 0.23495623270676924 1.0521227827611603 0.5392114119205623 0.9999887431203403 0.00037052907884504456 0.07600257529137193 0.007944155956378821 0.0033787612417608705 0.013414351398618702 1.0692310630830386e-07 6.970928432697402 -0.512911370840598 GFAFVYFENVDDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFAFVYFENVDDAK 14 0 P62995-3;P62995;H7BXF3 P62995-3 TRA2B Transformer-2 protein homolog beta 0 126649000.0 28067000.0 50717000.0 47865000.0 False True 42579690.972550824 41666155.096270375 38404461.77002525 1.0 0.9785452675814542 0.9019431774359953 25.343662143499483 -6.947487005781326 0.5857840218902634 1.0008971873526593 0.8757645656796489 0.9989890068431903 0.001338253173088704 0.08451083132144564 0.04026166935453245 0.001393517590888736 0.0064094017569405045 1.1285297029633643e-07 6.947487005781326 -0.12513262167301042 GFAFVYFENVDDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFAFVYFENVDDAK 14 0 P62995-3;P62995;H7BXF3 P62995-3 TRA2B Transformer-2 protein homolog beta 0 13449900.0 3400700.0 3571200.0 6478000.0 False True 4658030.690461965 3413412.575620844 4948029.818597883 1.0 0.7328016499784623 1.062257882656234 22.151288714418556 -6.69095753632014 1.8628563867617791 0.8326351280903359 1.0611372579706297 0.3749677791415311 0.11298410883444153 0.4146219720403157 2.7903505944977947 0.04850482543876463 0.12616501104447014 2.0372412617507103e-07 6.69095753632014 0.22850212988029384 GFAFVYFENVDDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFAFVYFENVDDAK 14 0 P62995-3;P62995;H7BXF3 P62995-3 TRA2B Transformer-2 protein homolog beta 0 31825600.0 14427000.0 7578300.0 9820300.0 False True 11996689.72446709 7537474.193725219 11873679.326063007 1.0 0.6282961689300541 0.9897463049199977 23.51613303863513 -10.762013280140232 9.855831721348796 1.0008618427114049 0.8090212372179264 0.271259523995537 0.14756140010582527 0.002805988768642496 6.775553066008658e-05 0.14346572387319623 0.04762523709607591 1.7297634645697447e-11 10.762013280140232 -0.19184060549347848 GFAFVYFENVDDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFAFVYFENVDDAK 14 0 P62995-3;P62995;H7BXF3 P62995-3 TRA2B Transformer-2 protein homolog beta 0 111091000.0 28067000.0 43050000.0 39974000.0 False True 36333284.783282444 40654229.65600856 32699142.167876747 1.0 1.1189252471528326 0.8999775925275595 25.114788465591932 -6.759194048137352 1.6153651221537229 1.0691487003649387 0.899206150919964 0.6876844852178001 0.050015003020912524 0.28429355190416083 1.46188310581036 0.02443062945002222 0.058760711079359276 1.7410287864144525e-07 6.759194048137352 -0.16994254944497467 GFAFVYFER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFAFVYFER 9 0 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 0 20645400.0 5280500.0 8160100.0 7204800.0 False True 6922786.636434747 6942644.887820677 6459316.409321709 1.0 1.0028685343675645 0.9330514933576334 22.72292145361906 -6.897318971287832 0.9780729046858675 1.003120102965578 0.9261095659702051 0.9851842211152098 0.003926346526385316 0.11340534165957407 0.18876358690988895 0.00302536458540182 0.007770667569104629 1.266721169949397e-07 6.897318971287832 -0.07701053699537297 GFAFVYFER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFAFVYFER 9 0 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 0 27055400.0 9905300.0 7351400.0 9798700.0 False True 9590861.673387105 10286852.357044555 7232126.515301046 1.0 1.072568107784173 0.7540643126330224 23.193229006682003 -6.846798949693498 1.250377208164783 1.0386447357090436 0.7420925330266755 0.9355243689318163 0.03460894742889055 0.16101429913534554 0.4860311978434921 0.021674923962667555 0.050066966723726396 1.4229873859564614e-07 6.846798949693498 -0.29655220268236804 GFAFVYFER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFAFVYFER 9 0 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 0 94361000.0 23763000.0 30452000.0 40146000.0 False True 36050208.30800318 25017602.67743805 32211125.503383078 1.0 0.6939655511472903 0.893507333665869 25.103504259989837 -10.15771764184493 4.814551263130846 1.0000181639516224 0.7937364433688173 0.5875737285910232 0.08146259159276474 1.5884171721592697e-05 2.7788496798825138e-06 0.07888275804506177 0.02629193838098326 6.954763371308577e-11 10.15771764184493 -0.20628172058280503 GFAFVYFER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFAFVYFER 9 0 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 0 21296300.0 5280500.0 6967000.0 9048800.0 False True 7232843.550146866 6659174.90321193 6911659.805885848 1.0 0.9206855999362399 0.9555937105463181 22.78613151514195 -10.089570449771117 4.291700212027242 1.0000076565293297 0.9381396552331499 0.8072130882716548 0.014251176507088653 14982219.372257687 0.6951871269801438 1133.808858149393 0.005215396568037166 8.136348649975586e-11 10.089570449771117 -0.06186800129617975 GFAFVYFER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFAFVYFER 9 0 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 0 20452800.0 9905300.0 4788600.0 5758900.0 False True 8236695.829192759 4762802.861337325 6963059.363854907 1.0 0.578241926144322 0.8453704626527803 22.97363428211628 -10.486020525160002 6.070693656697959 1.0002185106980033 0.7118061943985513 0.6081371542995581 0.1090547683636918 0.0003227620307154709 2.732697729817556e-05 0.10567089638841125 0.0351972751414238 3.265723976932192e-11 10.486020525160002 -0.28841231629945197 GFAFVYFER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFAFVYFER 9 0 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 0 100661000.0 23763000.0 44767000.0 32131000.0 False True 30761671.938758712 42275677.096644305 26283487.691900935 1.0 1.3742971182063195 0.8544232493027984 24.874630582082286 -6.713465639416813 1.7825150862448094 1.2292821408344048 0.8554956152299689 0.48173410235382896 0.15764330609618868 0.36813308496641084 2.2821091758841674 0.0703180337299819 0.17791659034422347 1.934346894545166e-07 6.713465639416813 -0.3737865256044359 GFAYIEFSDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFAYIEFSDK 10 0 Q92843-2;Q86U42-2;Q86U42;B4DEH8;G3V4T2;H0YJH9 Q92843-2 PABPN1 Polyadenylate-binding protein 2 0 12265100.0 2783000.0 3616600.0 5865500.0 False True 3811950.307747127 3456806.6535031185 4480189.703764414 1.0 0.9068341332985793 1.175301182352563 21.862097881847458 -6.812983372501265 1.4019955156741162 0.9494020076634918 1.180323679121184 0.8674688711409746 0.040517793959848954 0.202757760744454 0.7849057063047001 0.02272086806450053 0.05248963857374656 1.5382135315738316e-07 6.812983372501265 0.23092167145769216 GFAYVQFEDVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFAYVQFEDVR 11 0 Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3;O75494-2;O75494;Q8WXF0 Q5JRI1 SRSF10;SRSF12 Serine/arginine-rich splicing factor 10;Serine/arginine-rich splicing factor 12 0 13327400.0 7276700.0 6050700.0 0.0 False True 9539824.167663036 5147959.1454438735 0.0 1.0 0.539628304984259 0.0 23.185531244907338 -7.811476633873742 0.6183376974065825 1.004973032404849 2.899587038315786e-19 0.9881361722404114 0.044513422836782134 0.11642877111766287 0.15626213524178695 0.04349237697434573 0.07781284852430435 1.543559468439539e-08 7.811476633873742 -1.004973032404849 down GFAYVQFEDVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFAYVQFEDVR 11 0 Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3;O75494-2;O75494;Q8WXF0 Q5JRI1 SRSF10;SRSF12 Serine/arginine-rich splicing factor 10;Serine/arginine-rich splicing factor 12 0 19651600.0 7013000.0 4152500.0 8486100.0 False True 6790376.15372211 5810614.905001435 6263335.832456982 1.0 0.8557132585087169 0.9223842230041653 22.695060064277015 -10.21078928792792 4.737084026899111 1.0000202569836483 0.8890487407559968 0.7868975353622892 0.0272183072803693 5.8240811619273355e-06 9.702869235496506e-07 0.026358822849664953 0.008784670900519216 6.154754181668557e-11 10.21078928792792 -0.11097151622765145 GFAYVQFEDVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFAYVQFEDVR 11 0 Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3;O75494-2;O75494;Q8WXF0 Q5JRI1 SRSF10;SRSF12 Serine/arginine-rich splicing factor 10;Serine/arginine-rich splicing factor 12 0 44963100.0 6690100.0 25253000.0 13020000.0 False True 10149370.811823923 20746404.847410418 10446591.293131266 1.0 2.0441074852877628 1.0292846213640243 23.27488695765183 -6.639504124486559 2.0457895583791728 1.6830210121363172 1.0334589584823712 0.15289265769644766 0.44679301245628633 0.534607804454418 4.275510426261916 0.1778683507953553 0.4948847776531738 2.293484849161512e-07 6.639504124486559 -0.6495620536539459 GFAYVQFEDVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFAYVQFEDVR 11 0 Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3;O75494-2;O75494;Q8WXF0 Q5JRI1 SRSF10;SRSF12 Serine/arginine-rich splicing factor 10;Serine/arginine-rich splicing factor 12 0 13774700.0 7013000.0 4543700.0 2218000.0 False True 5831620.228577497 4519222.186246159 2681773.5451267054 1.0 0.7749513872834152 0.4598676594173329 22.475465339711292 -6.966377606013525 0.3335641198947892 1.0368264216881071 0.18762270196403835 0.9999387903559389 0.0017331415061144237 0.0774965487600722 0.013228322838371963 0.004541004375092496 0.027404788057539233 1.0804940855960607e-07 6.966377606013525 -0.8492037197240687 down GFAYVQFEDVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFAYVQFEDVR 11 0 Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3;O75494-2;O75494;Q8WXF0 Q5JRI1 SRSF10;SRSF12 Serine/arginine-rich splicing factor 10;Serine/arginine-rich splicing factor 12 0 30856600.0 6690100.0 16559000.0 7607500.0 False True 8660466.331586478 15637477.093469156 6223013.059541752 1.0 1.8056160597768394 0.7185540386947941 23.04601327974428 -6.70819176670652 1.8016182466774402 1.496168946707445 0.7212316595028178 0.4566244181242235 0.33957668126793067 0.3786693488051702 2.3947657872341983 0.1500583147442954 0.3820614905575324 1.9579799186321142e-07 6.70819176670652 -0.7749372872046273 GFCFITFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFCFITFK 8 0 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 1285470000.0 338130000.0 555600000.0 391740000.0 False True 443291704.45557755 472706645.711838 351206502.63542175 1.0 1.0663557223395055 0.7922695126152903 28.723681123964404 -6.842761971528943 1.2696298942814452 1.0352955610351864 0.782757523036801 0.929078943916863 0.031092109465233525 0.165599689644763 0.5173546678041274 0.01919402348956639 0.044254438527759205 1.4362764132084125e-07 6.842761971528943 -0.25253803799838537 GFCFITFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFCFITFK 8 0 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 713050000.0 361090000.0 135270000.0 216690000.0 False True 349627395.60067266 189284016.42373088 159932388.4393425 1.0 0.5413878283151525 0.45743666100470415 28.38124299298984 -13.999999999999998 0.23879979935261192 4.0180168810947015 0.41989260482722934 0.9995229923152388 0.005207978716299854 13.58141725219496 0.15467239861982104 19.53264727687846 0.041313204376743407 1.0000000000000041e-14 13.999999999999998 -3.5981242762674723 GFCFITFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFCFITFK 8 0 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 273237500.0 88869000.0 85253800.0 99114700.0 False True 134820770.19416448 70039593.2990203 79524636.10148369 1.0 0.519501507061201 0.5898544859738962 27.00646753119601 -10.609819974447202 6.502671979646404 1.0012925919148377 0.5546779965176071 0.9816251570942137 0.028721483370148022 0.0005395823384418864 3.237648661472876e-05 0.027879708971206254 0.009269818897579716 2.4557266627479844e-11 10.609819974447202 -0.4466145953972306 GFCFITFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFCFITFK 8 0 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 1194090000.0 338130000.0 314340000.0 541620000.0 False True 463145798.6196679 300451419.4166267 413700511.01404494 1.0 0.6487188706279409 0.8932403408322245 28.786891185487296 -10.109740513420457 5.439440091403855 1.0000032912510826 0.7709796057299937 0.5390945251621897 0.0998254721929218 3.984423453748567e-06 6.521835326945108e-07 0.09665698755117406 0.03221853261082789 7.767110550494475e-11 10.109740513420457 -0.22902368552108887 GFCFITFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFCFITFK 8 0 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 786783000.0 361090000.0 95843000.0 329850000.0 False True 300262333.99929404 95326674.73565398 398820109.9459165 1.0 0.3174779649047759 1.3282388924175024 28.161648268424116 -6.724794916911313 1.7418920035907377 0.5869069409253693 1.3271238540920718 0.5351156226435737 0.2870521470874218 0.3460846136222545 2.0546178471345398 0.130716701078544 0.3263327960951935 1.8845387986948468e-07 6.724794916911313 0.7402169131667025 GFCFITFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFCFITFK 8 0 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 402747000.0 88869000.0 221511000.0 92367000.0 False True 115042672.36988363 209183718.1261816 75557153.76545434 1.0 1.8183141421960103 0.656775022771759 26.777593853288458 -6.717405147664167 1.768824189104057 1.4992274564676793 0.6588636989471236 0.5001938093795255 0.3444630567262196 0.3603698323019327 2.2021092637752795 0.15471918731579887 0.38956823627990145 1.9168796742267233e-07 6.717405147664167 -0.8403637575205557 GFCFITFKEEEPVKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFCFITFKEEEPVKK 15 2 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 27553300.0 12164400.0 3820400.0 11568500.0 False True 15947646.200217156 3250411.211802562 10371502.592887819 1.0 0.2038176149003294 0.6503469203340235 23.92684016871171 -10.309171051668383 5.74047967734648 1.0000620015755617 0.42708226764266294 0.6870054127152685 0.18229482558533477 0.00014466829121789805 1.7409844813023535e-05 0.17652518674846376 0.058835401965980354 4.907145647463298e-11 10.309171051668383 -0.5729797339328988 GFCFITFKEEEPVKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFCFITFKEEEPVKK 15 2 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 69518200.0 7704900.0 43080000.0 18733300.0 False True 11688896.603641523 35392037.41442368 15030655.04390291 1.0 3.027833902080865 1.2858916930807913 23.478635414475825 -6.6091965075039365 2.156097257487446 2.355546779107099 1.2920199440502875 0.047904596852383574 0.8744485696833121 0.6150462348772376 5.416639374236529 0.33500209025470873 0.9712513343462346 2.459254600525039e-07 6.6091965075039365 -1.0635268350568117 GFCFITFKEEEPVKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFCFITFKEEEPVKK 15 2 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 37629600.0 12164400.0 17988800.0 7476400.0 False True 16661907.410549454 17193995.334993362 5710628.301291326 1.0 1.0319343945043782 0.34273556805841165 23.9900502302346 -6.896036643641044 0.9859943491275579 1.0318527860400477 0.2759460371896777 0.9844888735889881 0.03955906795092145 0.11438137992726781 0.1943334329486573 0.030301340323052102 0.0773816306577078 1.2704669049118792e-07 6.896036643641044 -0.75590674885037 down GFCFITFKEEEPVKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFCFITFKEEEPVKK 15 2 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 43177300.0 7704900.0 18445700.0 17026700.0 False True 9974144.936285058 17419180.57992657 13928015.308695318 1.0 1.746433472864138 1.3964119628968323 23.249761736568274 -10.178648462628887 4.750535825403562 0.9999283716886775 1.5714227178835023 0.7803918504217287 0.14289568308016018 0.00010842115097744148 1.8746221166487112e-05 0.13837540799936196 0.04611938339972018 6.627527483487105e-11 10.178648462628887 0.5714943461948248 GFCFITYTDEEPVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFCFITYTDEEPVK 14 0 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 12199800.0 3163300.0 4222700.0 4813800.0 False True 4147116.9334407775 3592689.6199556766 4315714.153230181 1.0 0.8663101806909737 1.0406540790856171 21.983677295834205 -6.701833881927146 1.824437476236243 0.9171334646972853 1.0401519627051414 0.4262547733338222 0.056413386775525536 0.3917101802807953 2.536123005635573 0.02465692502164277 0.06326541383303075 1.986854745954175e-07 6.701833881927146 0.12301849800785614 GFCFITYTDEEPVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFCFITYTDEEPVK 14 0 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 10921900.0 3163300.0 3548100.0 4210500.0 False True 4332857.494968199 3391333.21000233 3216066.6179694897 1.0 0.7827013036871688 0.7422507252325624 22.046887357357097 -13.999999999999998 0.23642133692197487 2.413772823660591 0.7237475965637362 0.9995192016930057 0.002481728209219872 13.49977848568509 0.1539127721558106 8.9919942497012 0.02018998286523544 1.0000000000000041e-14 13.999999999999998 -1.690025227096855 GFCFITYTDEEPVKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFCFITYTDEEPVKK 15 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 103871000.0 29663000.0 32859000.0 41349000.0 False True 38888480.256900586 27956565.283378817 37070602.12761532 1.0 0.7188906611596901 0.9532540711985603 25.212839520257152 -10.041086782929955 6.4126551895965465 1.0000001162712255 0.8360723665845726 0.39479187622872414 0.09567846149565554 1.5906447389309115e-07 2.378728882539979e-08 0.09264033825210191 0.030880090663617663 9.097314673042259e-11 10.041086782929955 -0.1639277496866529 GFCFITYTDEEPVKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFCFITYTDEEPVKK 15 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 47209300.0 20680000.0 9188300.0 17341000.0 False True 20023524.71965967 12857236.106351513 12798871.881151134 1.0 0.6421065365044302 0.6391917537168086 24.255192616806287 GFCFITYTDEEPVKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFCFITYTDEEPVKK 15 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 106913000.0 16914000.0 59925000.0 30074000.0 False True 25659774.579033185 49230915.553838 24129860.71809751 1.0 1.9186028077606336 0.9403769563047613 24.613005160627463 -6.660366326478672 1.9715641504623764 1.5911316335292085 0.9444575174248111 0.23707177996050333 0.3910897058378918 0.4836447414291946 3.614327316925129 0.1602396763767172 0.4335649523135928 2.1859170297032474e-07 6.660366326478672 -0.6466741161043974 GFCFITYTDEEPVKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFCFITYTDEEPVKK 15 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 94115000.0 29663000.0 27505000.0 36947000.0 False True 40630212.712433696 26289738.153128136 28220879.54735037 1.0 0.6470489913306047 0.694578680822761 25.276049581780043 -10.139073255457301 6.736989392962972 1.0000005216504944 0.6708138360770102 0.9846053331901395 0.019403914481451588 1.5203179427622863e-07 1.9427290187751036e-08 0.018787789083956875 0.006262586469824492 7.259834904447517e-11 10.139073255457301 -0.3291866855734842 GFCFITYTDEEPVKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFCFITYTDEEPVKK 15 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 41914200.0 20680000.0 5161200.0 16073000.0 False True 17196336.2793359 5133395.5911820065 19433789.9868447 1.0 0.2985168182219481 1.1301122326967663 24.035597892240563 -6.683087512326687 1.8906150903726648 0.5573832560340137 1.1270417757966154 0.3382493488392003 0.29711025915256695 0.43181470879544764 2.98669874383339 0.12596695569024993 0.33095778159476374 2.0744954550025195e-07 6.683087512326687 0.5696585197626016 GFCFITYTDEEPVKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFCFITYTDEEPVKK 15 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 73123000.0 16914000.0 36293000.0 19916000.0 False True 21895506.424784947 34273262.64588895 16291492.355416844 1.0 1.5653103418102636 0.7440564305457418 24.384131482719912 -6.721502760050724 1.753914134940531 1.343390149230268 0.7452370519484327 0.5194811806154911 0.23784433112272946 0.3524665142424912 2.119802086490637 0.10764007501997575 0.26973978071949134 1.8988787742105483e-07 6.721502760050724 -0.5981530972818353 GFCFLEYEDHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFCFLEYEDHK 11 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5;O43390;O43390-3;B4DT28;O43390-2;O43390-4 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 47149100.0 9629100.0 16465500.0 21054500.0 False True 12623843.348337054 14008911.582016291 18875982.309025045 1.0 1.1097184269053602 1.4952643017002891 23.58964787211063 -6.947853623555501 0.5819397958987118 0.9954241180522573 1.6286916693392623 0.9990218294114412 0.006642523674468371 0.08435941834313677 0.03962026005620412 0.006945113081438344 0.03222399377082171 1.1275774355931999e-07 6.947853623555501 0.6332675512870051 GFCFLEYEDHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFCFLEYEDHK 11 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5;O43390;O43390-3;B4DT28;O43390-2;O43390-4 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 14929100.0 7746700.0 2429100.0 4753300.0 False True 7500785.248829191 3399052.2975891563 3508268.134056609 1.0 0.45315952728012304 0.4677201143179269 22.838610206971357 -9.943122538280967 5.9159933029675384 1.0000003016892642 0.4604398208276091 0.9994541132891898 0.005944334767037544 2.3651253475270953e-08 4.218662861911865e-09 0.005755580647908335 0.001918525796315254 1.1399281059727971e-10 9.943122538280967 -0.5395604808616552 GFCFLEYEDHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFCFLEYEDHK 11 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5;O43390;O43390-3;B4DT28;O43390-2;O43390-4 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 54657500.0 9629100.0 23648800.0 21379600.0 False True 13189238.486643156 22603917.8198763 16330178.806683423 1.0 1.7138152322264444 1.2381441751334712 23.65285793363352 -10.178045162781938 4.023074270747247 0.9997783090397455 1.4759797032855528 0.5717462482521956 0.19419189636591955 13265918.224911597 11238758.00493243 23865.016389104523 0.06647704985148808 6.636740505865298e-11 10.178045162781938 0.4762013942458073 GFCFLEYEDHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFCFLEYEDHK 11 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5;O43390;O43390-3;B4DT28;O43390-2;O43390-4 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 12459100.0 7746700.0 1560500.0 3151900.0 False True 6441724.286998622 1552093.2767650008 3810947.71726098 1.0 0.24094376095816483 0.5916036681285232 22.619015482405633 -10.621046478140162 6.5653183151393195 1.0018978363149382 0.4162737145495392 0.7869960939763113 0.14315630763651568 0.003986376659301658 0.00023009544804265776 0.13894648742852844 0.04620349961506427 2.3930596377629744e-11 10.621046478140162 -0.585624121765399 GFCFLEYEDHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFCFLEYEDHK 11 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5;O43390;O43390-3;B4DT28;O43390-2;O43390-4 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 8686400.0 1789400.0 3673500.0 3223500.0 False True 2316413.574347294 3469066.495733972 2636856.0759031028 1.0 1.4976023859260392 1.1383356172250465 21.143461425584174 -10.270004050168888 9.569390398828434 0.9999999671324773 1.317969001575543 0.5108631569202158 0.14667004414265636 1.0281990438383839e-07 7.96096089925798e-09 0.1420126744010052 0.047337553196001254 5.370267881110601e-11 10.270004050168888 0.3179690344430657 GFCFLEYEDHK(ub)SAAQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFCFLEYEDHKSAAQAR 17 1 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 12355400.0 4600800.0 3934400.0 3820200.0 True False 6031693.354210583 3347402.8561710822 3424922.3499459787 1.0 0.554969004489318 0.5678210328041828 22.524131654494905 -10.108595918439528 5.326612080415026 1.0000078326696307 0.5613950186464506 0.9993564557125251 0.0052468185895871 4.880536133606481e-07 8.167844170536336e-08 0.005080300972393543 0.0016934034180185174 7.787607981613241e-11 10.108595918439528 -0.4386128140231801 GFCFLEYEDHK(ub)SAAQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFCFLEYEDHKSAAQAR 17 1 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 38947000.0 11596300.0 9139700.0 18211000.0 True False 17592434.903088707 7508649.126197963 14611587.867835151 1.0 0.4268112496968608 0.830560860297388 24.068451838863457 -10.512962194503004 5.680268317804951 1.0006356760421067 0.6286860549971438 0.530010904252874 0.1648300883031164 0.0013290937770762388 0.00011395912825947255 0.15985816372616293 0.05319868224598887 3.0692891595310036e-11 10.512962194503004 -0.3719496210449629 GFCFLEYEDHK(ub)SAAQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFCFLEYEDHKSAAQAR 17 1 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 10930800.0 3807300.0 2246300.0 4877200.0 True False 3165938.641988185 2234198.7360443617 5896999.970375094 1.0 0.7056986848744808 1.8626387423199786 21.594201864673824 -6.839246183197818 1.285790121395383 0.84341400989164 1.9001505645835675 0.92316491826304 0.1360865627167844 0.16968226594721875 0.5452389402238631 0.08299912477869241 0.19118776980545168 1.4479508386963264e-07 6.839246183197818 1.0567365546919274 GFCFLEYEDHK(ub)SAAQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFCFLEYEDHKSAAQAR 17 1 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 40503000.0 11596300.0 10592500.0 18314200.0 True False 15011638.94724687 10003018.063444154 14981203.519560918 1.0 0.6663508294195088 0.9979725446506603 23.839578160955906 -10.931628515692616 10.108366543159242 1.0341796082750554 0.8321616870350845 0.2545851487958729 0.1353839983238116 0.07699115871758627 0.0005207560713316362 0.09677798232649984 0.043694997570924564 1.1705001786220957e-11 10.931628515692616 -0.20201792123997087 GFCFLEYEDHK(ub)TAAQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFCFLEYEDHKTAAQAR 17 1 O60506;O60506-3;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 20836900.0 6909700.0 6399300.0 7527900.0 True False 9058683.613629974 5444549.38427603 6748985.120715748 1.0 0.60103096834997 0.7450293451645685 23.110869985813036 -10.085612860195683 5.60545673653944 1.000002448782125 0.6730301567571922 0.8730072537712485 0.05878709116440304 1.7990924371935598e-06 2.9340062756115135e-07 0.05692078284100498 0.01897345208760298 8.210831500613957e-11 10.085612860195683 -0.32697229202493283 GFCFLEYEDHK(ub)TAAQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFCFLEYEDHKTAAQAR 17 1 O60506;O60506-3;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 15121500.0 6463600.0 5336400.0 3321500.0 True False 6258416.555995764 7467252.348958373 2451499.507135891 1.0 1.1931536167570223 0.3917124220162807 22.577366255910206 -6.843054943856319 1.2680590746404587 1.102752778399765 0.36370647083614865 0.9295844551519019 0.0906214802248667 0.16526702754017633 0.5148751894655715 0.05600568640932223 0.12915701670814078 1.4353078369034363e-07 6.843054943856319 -0.7390463075636164 down GFCFLEYEDHK(ub)TAAQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFCFLEYEDHKTAAQAR 17 1 O60506;O60506-3;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 70072100.0 13703600.0 15115500.0 41253000.0 True False 20789363.0673548 12418020.927059464 33099326.468167778 1.0 0.5973257038624373 1.592127972412157 24.309342222617303 -6.796827707503075 1.468870289568447 0.7769257219000913 1.6048026051145508 0.8227148400393416 0.17203103831070046 0.22531713231855144 0.9600616365958015 0.09215188058970789 0.21473486255180949 1.5965123870363466e-07 6.796827707503075 0.8278768832144594 GFCFLEYEDHK(ub)TAAQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFCFLEYEDHKTAAQAR 17 1 O60506;O60506-3;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 20104100.0 6909700.0 6426200.0 6768200.0 True False 9464402.817621382 6142269.235398366 5169690.555454491 1.0 0.6489864552216995 0.5462246963780173 23.174080047335927 -13.999999999999998 0.1722149671905464 2.780669700143279 0.4576819320123827 0.9995096268370642 0.004302078165392369 12.113819318866367 0.1314542429953546 7.207767015780302 0.08212032920699958 1.0000000000000041e-14 13.999999999999998 -2.322987768130896 GFCFLEYEDHK(ub)TAAQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFCFLEYEDHKTAAQAR 17 1 O60506;O60506-3;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 17764100.0 6463600.0 4488000.0 6812500.0 True False 5374769.786030738 4463822.2532017445 8236962.252558904 1.0 0.8305141300755642 1.5325237322661018 22.357771531344483 -6.842934985774731 1.2686723369671133 0.9098434556228193 1.5569914976621815 0.929389861578015 0.07947742501974762 0.16539570761241995 0.5158370583277072 0.04909718612382914 0.11321678652132985 1.435704343335729e-07 6.842934985774731 0.6471480420393622 GFCFLEYEDHK(ub)TAAQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFCFLEYEDHKTAAQAR 17 1 O60506;O60506-3;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 56453900.0 13703600.0 15987700.0 26762600.0 True False 17739580.33834001 15097970.440682195 21892081.407465283 1.0 0.851089493253198 1.2340811332582993 24.080468544709753 -6.8013163057875055 1.4509877804479683 0.9179759063852836 1.2395134693215402 0.8358497262494198 0.06386823086525525 0.21889269428904956 0.9097594095260104 0.034629171341594225 0.08045452945037081 1.5800968024170596e-07 6.8013163057875055 0.32153756293625657 GFCK(ub)HGPLCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFCKHGPLCR 10 1 O95639-3;O95639-2;O95639;C9K0K2;B7Z7B0;H7C419 O95639-3 CPSF4 Cleavage and polyadenylation specificity factor subunit 4 1 18192400.0 3584300.0 4950700.0 9657400.0 True False 5437645.14742985 4067208.9050043467 7748610.657011216 1.0 0.747972476086776 1.4249938064961196 22.37455057564323 -6.805871679163493 1.4315874435874687 0.8619638523912178 1.4357789546193112 0.8488481311445923 0.1086193690275254 0.21247298219956104 0.858934186124032 0.05967035656887821 0.1383202371892959 1.5636095735603376e-07 6.805871679163493 0.5738151022280934 GFCK(ub)HGPLCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFCKHGPLCR 10 1 O95639-3;O95639-2;O95639;C9K0K2;B7Z7B0;H7C419 O95639-3 CPSF4 Cleavage and polyadenylation specificity factor subunit 4 1 15191200.0 3584300.0 2978900.0 8628000.0 True False 4639947.007115794 2813121.59633645 7057792.530756004 1.0 0.6062831303940032 1.5210933486809692 22.14567689773568 -6.789733459046984 1.4973763640870783 0.7798845736670923 1.530757868476278 0.8005071648034366 0.1673469551005604 0.23572468534331745 1.0441258171846362 0.08797011943016052 0.20600155216062954 1.6228057616053209e-07 6.789733459046984 0.7508732948091856 GFCYVEFDEVDSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFCYVEFDEVDSLK 14 0 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 3410250.0 888570.0 1629800.0 891880.0 False True 1164923.8749241214 1386640.1929106438 799596.8131170672 1.0 1.1903268726473342 0.6863940471381873 20.151804250506054 -6.804379885239483 1.4379902063422507 1.104435129976756 0.6786637382273168 0.8446566603282215 0.08189030383503522 0.21456272128556175 0.8754154186009522 0.0447917114394352 0.10390252609100017 1.5689897801736341e-07 6.804379885239483 -0.42577139174943923 GFCYVEFDEVDSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFCYVEFDEVDSLK 14 0 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 11835000.0 6295400.0 1645300.0 3894300.0 False True 6095555.972927742 2302276.8701261505 2874266.0035042297 1.0 0.3776976013921089 0.4715346748138707 22.539326383738988 -10.784383208464833 7.170271673871873 1.0163654029904288 0.4246161381029898 0.9804423402324217 0.03830882480656624 0.009605782459774418 0.0002888545223616275 0.03555119472526809 0.012364120040717385 1.642921418722085e-11 10.784383208464833 -0.591749264887439 GFCYVEFDEVDSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFCYVEFDEVDSLK 14 0 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 3499970.0 888570.0 1010300.0 1601100.0 False True 1217098.3417013541 965661.605384672 1222953.1556895748 1.0 0.7934129661493051 1.0048104691195587 20.215014312028945 -11.055164720638858 9.823547706583593 1.3513613548687124 0.8991117176344319 0.23294236560745174 0.08630266919593545 0.04792591593629483 0.0002691311229923561 0.006030215475854929 0.027854066710758827 8.807147692589623e-12 11.055164720638858 -0.4522496372342806 GFDILGIKPVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFDILGIKPVQR 12 1 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 5947600.0 1476700.0 1508600.0 2962300.0 False True 1935968.0003831398 1283522.7604767436 2655789.6123880832 1.0 0.6629875908190253 1.371814829512929 20.8846236758261 -6.777377555485351 1.5457702023130253 0.808531258313787 1.377008958018334 0.75813915395061 0.14237114466438278 0.2546527654970095 1.2016000312074304 0.0725523343496524 0.17159479446465167 1.669638476917093e-07 6.777377555485351 0.568477699704547 GFDILGIKPVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFDILGIKPVQR 12 1 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 6370700.0 1476700.0 2076100.0 2817900.0 False True 2022675.8963169882 1984371.037255385 2152370.0564722093 1.0 0.9810622852967442 1.0641200898232763 20.94783373734899 -6.846751157068625 1.2505724425899356 0.9899150057968192 1.0672396287446393 0.9354508566208036 0.009029793409581243 0.16107245615484816 0.48637651324175235 0.00565426693849507 0.013060735649026768 1.4231439894763026e-07 6.846751157068625 0.07732462294782005 GFDQDMANK(ub)IGEHMEEHGIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFDQDMANKIGEHMEEHGIK 20 1 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 1 10297400.0 1472300.0 5733700.0 3091400.0 True False 1930199.5577734832 4878254.309787548 2771531.5828027306 1.0 2.527331586074289 1.4358782601731281 20.88031858061392 -10.305714119832311 5.951161355816588 0.9999275455784004 1.9816049231236543 0.5188732943843835 0.445583954420254 0.00042844357077268273 4.998508488005316e-05 0.43146622862042894 0.14381160290057293 4.9463618074505067e-11 10.305714119832311 0.981677377545254 GFDQTINLILDESHER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFDQTINLILDESHER 16 0 F2Z2Y6;O95777;C9JIZ0;C9JNV3 F2Z2Y6 LSM8 U6 snRNA-associated Sm-like protein LSm8 0 10402100.0 5098300.0 1812400.0 3491400.0 False True 4936457.257168322 2536100.7715411396 2576897.6002451475 1.0 0.5137491604649104 0.5220135546607207 22.235044604835707 -10.056588369948356 4.940514047851872 1.000010524840178 0.5178813575588865 0.9997796662447505 0.0033739248157573184 3.9114421824713573e-07 7.468909112628938e-08 0.003266859916877112 0.0010889295499567878 8.778324481678042e-11 10.056588369948356 -0.4821291672812915 GFDQTINLILDESHER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFDQTINLILDESHER 16 0 F2Z2Y6;O95777;C9JIZ0;C9JNV3 F2Z2Y6 LSM8 U6 snRNA-associated Sm-like protein LSm8 0 2456420.0 0.0 732420.0 1724000.0 False True 0.0 700059.2626109489 1316826.7068945258 0.0 GFDQTINLILDESHER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFDQTINLILDESHER 16 0 F2Z2Y6;O95777;C9JIZ0;C9JNV3 F2Z2Y6 LSM8 U6 snRNA-associated Sm-like protein LSm8 0 7484400.0 5098300.0 1341300.0 1044800.0 False True 4239462.342985407 1334074.1506727953 1263262.849390614 1.0 0.31468003316037174 0.2979771365302495 22.015449880269983 GFDYLLK(ub)AAEAGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFDYLLKAAEAGDR 14 1 O00418 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 25584800.0 8100200.0 11653400.0 5831200.0 True False 10619440.64244839 9914758.144597422 5227843.360820105 1.0 0.9336422207555654 0.49228989895411174 23.340204441312313 -6.933695561790528 0.7158045516553192 1.0058791961147984 0.3925202313267313 0.9972160751343656 0.011889095361267572 0.09076375627551769 0.06860832051783193 0.011080340229858567 0.03915498929349311 1.1649423618891382e-07 6.933695561790528 -0.6133589647880671 down GFDYLLK(ub)AAEAGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFDYLLKAAEAGDR 14 1 O00418 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 20380800.0 8100200.0 9188500.0 3092100.0 True False 11095062.839674203 8782521.687693803 2361809.663798474 1.0 0.791570251976301 0.2128703278140087 23.403414502835204 -7.005728628972476 0.5427428602710167 1.0076006323210176 4.640483236422485e-22 0.9993967283800359 0.008178632670123585 0.07564298649842256 0.03211721640409079 0.009157666691327683 0.04359577699155559 9.8689595976684e-08 7.005728628972476 -1.0076006323210176 down GFELTFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFELTFK 7 0 A0A0C4DGS1;P39656;P39656-3;U3KQ84 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 0 14597300.0 5085800.0 4668900.0 4842600.0 False True 6667533.0509572625 3972318.3192296554 4341534.205499293 1.0 0.5957703229771537 0.651145509488847 22.668721640556537 -10.24026126955827 5.473708446822043 1.0000261351631434 0.6234579162331546 0.9840383900366007 0.022606825227600328 7.21072388274199e-06 1.0008112881760017e-06 0.021890481359335964 0.007296321468080976 5.7509385943343496e-11 10.24026126955827 -0.3765682189299888 GFELTFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFELTFK 7 0 A0A0C4DGS1;P39656;P39656-3;U3KQ84 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 0 6856930.0 3534100.0 909630.0 2413200.0 False True 3421911.929968535 1272850.0026577853 1781110.5255518083 1.0 0.3719704155768525 0.5205015681301259 21.706371198867256 -10.201519950564043 8.145904477671086 1.0000001733734194 0.4462359918544811 0.948805409804021 0.060637589110501114 1.9090100937396436e-07 1.879518856096123e-08 0.05871211156660649 0.019570697731594935 6.287529698815623e-11 10.201519950564043 -0.5537641815189382 GFELTFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFELTFK 7 0 A0A0C4DGS1;P39656;P39656-3;U3KQ84 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 0 12139200.0 5085800.0 3724000.0 3329400.0 False True 6966157.698577204 3559461.3663788163 2543064.2911453815 1.0 0.5109647987305563 0.365059822241002 22.73193170207943 -13.999999999999998 0.1695031016226952 3.463026602309164 0.23567175499891507 0.9995146349042703 0.005982237077000472 12.086756382378262 0.13036508959131446 9.788060314907359 0.11949512899496213 1.0000000000000041e-14 13.999999999999998 -3.227354847310249 GFELTFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFELTFK 7 0 A0A0C4DGS1;P39656;P39656-3;U3KQ84 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 0 5344000.0 3534100.0 664100.0 1145800.0 False True 2938760.737176067 660522.3614864713 1385381.4824193767 1.0 0.22476221120375545 0.4714169019933982 21.486776474301532 -10.226885733960202 5.434074093064414 1.0000410230299537 0.3480895566040636 0.9030443290596345 0.10069635584997529 5.004897740572817e-05 7.120650267712555e-06 0.0975049366210119 0.03249960910253031 5.930813480738769e-11 10.226885733960202 -0.6519514664258901 GFELTFK(ub)TADDPSLSLIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFELTFKTADDPSLSLIK 18 1 A0A0C4DGS1;P39656;P39656-3;U3KQ84 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 1 90789000.0 11368000.0 43534000.0 35887000.0 True False 17246087.112123057 35765017.567305505 28793918.72016913 1.0 2.0738047613226223 1.6695913996589162 24.039765736578666 -10.147457121475247 4.736781230829713 0.999929026161802 1.8716980804211358 0.8611270536644858 0.16501941398464998 0.00013909502640389564 2.503505500844439e-05 0.1597938651465244 0.05325978683168417 7.121031035018776e-11 10.147457121475247 0.8717690542593338 GFELTFK(ub)TADDPSLSLIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFELTFKTADDPSLSLIK 18 1 A0A0C4DGS1;P39656;P39656-3;U3KQ84 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 1 88597200.0 11368000.0 31210000.0 46019200.0 True False 14716100.096781092 29473136.064205043 37644177.79686673 1.0 2.002781706455762 2.558026756361951 23.810892058671115 -9.115892093723438 0.1835673784811802 1.1485016684706954e-20 3.2268140211047776 0.9996562922640145 0.01195323671217653 0.570806643905026 0.06374216435098559 0.6673839823877638 0.33944359694951437 7.657868532685225e-10 9.115892093723438 3.2268140211047776 GFENVIHDK(ub)LPLQESEEEEREER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFENVIHDKLPLQESEEEEREER 23 2 P23497;E9PHV6;P23497-7;P23497-6;P23497-5;P23497-2;P23497-3;P23497-4;C9JBL0 P23497 SP100 Nuclear autoantigen Sp-100 1 30466700.0 5061500.0 4061600.0 21343600.0 True False 4900825.453025026 5683418.060964191 15753070.865724988 1.0 1.1596858764794635 3.214370929289357 22.22459333420294 -6.9224118425154515 0.8066348638118452 0.9584840151242391 3.564815896392577 0.9948251199896486 0.07253628444937392 0.09677341165115917 0.09841183336048982 0.06330927250334985 0.19424437430234603 1.195606197276129e-07 6.9224118425154515 2.606331881268338 up GFENVIHDK(ub)LPLQESEEEEREER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFENVIHDKLPLQESEEEEREER 23 2 P23497;E9PHV6;P23497-7;P23497-6;P23497-5;P23497-2;P23497-3;P23497-4;C9JBL0 P23497 SP100 Nuclear autoantigen Sp-100 1 102111400.0 13900400.0 41298000.0 46913000.0 True False 21087923.055362005 33928049.23725321 37640624.98730163 1.0 1.60888529174647 1.784937515585765 24.329913675640825 -11.232128985482467 0.22977699011039032 1.3204905055647144e-08 1.8861594437097278 0.9992949421436953 0.008929674089455823 3.4499345850805674 0.12782745688848174 1.8599105497057644 0.09066361062637347 5.859641072991452e-12 11.232128985482467 1.8861594305048228 GFENVIHDK(ub)LPLQESEEEEREER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFENVIHDKLPLQESEEEEREER 23 2 P23497;E9PHV6;P23497-7;P23497-6;P23497-5;P23497-2;P23497-3;P23497-4;C9JBL0 P23497 SP100 Nuclear autoantigen Sp-100 1 15940000.0 5061500.0 6719000.0 4159500.0 True False 4208861.512468993 6682803.413382929 5029232.218644958 1.0 1.5877936096459202 1.1949151103559883 22.004998609637216 -10.165963240543299 4.719621249381609 0.9999546859829667 1.391354360003744 0.569523705362902 0.16039197570469513 112375842.54892702 4.502058959857069 55338.59081062273 0.0549064394587364 6.823964509455609e-11 10.165963240543299 0.39139967402077724 GFESPSDNSSAMLLQWHEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFESPSDNSSAMLLQWHEK 19 0 O15511;B1ALC0;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 0 14824800.0 3169200.0 5028700.0 6626900.0 False True 4154851.890576461 4278437.561719069 5941211.9577134615 1.0 1.0297449041259235 1.4299455466002553 21.986365618993847 -6.921807650617732 0.8111888190243145 0.9917324710648258 1.4972476051395776 0.9946690288231689 0.014313841645111286 0.09711927312963205 0.10018173647790572 0.012452502504527493 0.037971970355299325 1.197270686064515e-07 6.921807650617732 0.5055151340747518 GFESPSDNSSAMLLQWHEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFESPSDNSSAMLLQWHEK 19 0 O15511;B1ALC0;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 0 11900200.0 3169200.0 4676100.0 4054900.0 False True 4340938.884409705 4469494.440205151 3097216.133286904 1.0 1.029614689176378 0.7134899190611557 22.04957568051674 -6.883964270993729 1.0574704421061674 1.0195238783608376 0.689313645085934 0.9767438489521858 0.02173974349751353 0.12417525379668233 0.25157207706986806 0.015776014551336048 0.038564305551229396 1.3062783500258425e-07 6.883964270993729 -0.3302102332749036 GFESPSDNSSAMLLQWHEK(ub)ALAAGGVGSIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFESPSDNSSAMLLQWHEKALAAGGVGSIVR 31 1 O15511;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 19184800.0 5895700.0 3130100.0 10159000.0 True False 5708544.2306430135 4379965.253255862 7498053.136532744 1.0 0.7672648360582992 1.313479029606846 22.444691451688932 -6.790956944869564 1.4927645113571038 0.8700855855841656 1.319421266903323 0.8043290746751817 0.09899801337404258 0.23393076272408467 1.0298211463865539 0.052200398446235516 0.12211570899618186 1.6182404589779038e-07 6.790956944869564 0.44933568131915735 GFESPSDNSSAMLLQWHEK(ub)ALAAGGVGSIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFESPSDNSSAMLLQWHEKALAAGGVGSIVR 31 1 O15511;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 65516600.0 9260600.0 18821000.0 37435000.0 True False 14049007.24054598 15462245.500855805 30035955.84165659 1.0 1.1005934608839238 2.13794151624975 23.74396485161545 -6.925697366198927 0.7812894195194431 0.9814600020358308 2.3293156834112407 0.9956233213617821 0.03402842079534786 0.0949335406778685 0.08907751869642569 0.030242177564945495 0.09617737289079605 1.1865953273185864e-07 6.925697366198927 1.34785568137541 up GFESPSDNSSAMLLQWHEK(ub)ALAAGGVGSIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFESPSDNSSAMLLQWHEKALAAGGVGSIVR 31 1 O15511;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 17914600.0 5895700.0 4970400.0 7048500.0 True False 4902535.773795004 4943623.468652842 8522308.761418203 1.0 1.0083809066886282 1.7383470829466623 22.22509672712321 -6.909408218474192 0.8997589236161452 0.9769734079647392 1.8314973457493886 0.9906961819744051 0.033383686082454185 0.10481072791622725 0.1409011352972166 0.027251910396374902 0.07492236435366702 1.231946311321684e-07 6.909408218474192 0.8545239377846494 GFESPSDNSSAMLLQWHEK(ub)ALAAGGVGSIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GFESPSDNSSAMLLQWHEKALAAGGVGSIVR 31 1 O15511;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 93358400.0 13698100.0 22855300.0 56805000.0 True False 17732460.479918797 21583382.46357664 46467072.868520446 1.0 1.2171679439533414 2.6204526394485574 24.079889396494025 -6.934287449953505 0.7107244042349069 0.9816748554992392 2.9427350042387936 0.9973157482550922 0.037209514045160014 0.09047196169209334 0.06721822927829944 0.03480998897947292 0.12411626767096978 1.1633557749634457e-07 6.934287449953505 1.9610601487395545 up GFEVVYMTEPIDEYCVQQLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 GFEVVYMTEPIDEYCVQQLK 20 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 20026000.0 5166600.0 8616400.0 6243000.0 False True 6773462.633425574 7330866.706464138 5597034.247084637 1.0 1.0822923374948428 0.8263180222571072 22.691462105780783 -6.820209748025505 1.3711863460558804 1.0443449153468316 0.8207147426166522 0.8848143638794749 0.03621226851512619 0.193212763922063 0.7137820435699602 0.020754008439066413 0.04782682696052061 1.5128304313370406e-07 6.820209748025505 -0.22363017273017938 GFEVVYMTEPIDEYCVQQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFEVVYMTEPIDEYCVQQLK 20 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 11901500.0 5882200.0 2726500.0 3292800.0 False True 5695472.780753491 3815205.668509671 2430316.8981174366 1.0 0.6698663684957392 0.42671029985958675 22.44138417423176 -7.740673094209472 0.17036179832434212 1.2781845827617655 1.9901005610434615e-15 0.9999505406035021 0.0016522661405242803 0.13148638856220315 0.021968804426087323 0.05782219074037519 0.08849490364706332 1.8168827674380028e-08 7.740673094209472 -1.2781845827617635 down GFEVVYMTEPIDEYCVQQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFEVVYMTEPIDEYCVQQLK 20 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 53494200.0 9583200.0 33779000.0 10132000.0 False True 14538415.025765082 27750873.533468377 8129405.758986633 1.0 1.9087963498282365 0.5591672644218536 23.793366659802725 -6.725272972506109 1.740244255066116 1.549749077791914 0.5606011046988604 0.5373710953911696 0.38219722065129974 0.3451451483271153 2.0454190999252866 0.17419560217616215 0.4346236225013131 1.8824655081308399e-07 6.725272972506109 -0.9891479730930537 GFEVVYMTEPIDEYCVQQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GFEVVYMTEPIDEYCVQQLK 20 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 19484700.0 5166600.0 5692200.0 8625900.0 False True 7076831.642115098 5440699.782411785 6588640.075986949 1.0 0.7688044675294392 0.9310155178451807 22.754672167303674 -10.213062583083879 7.231330060444446 1.0000003060183096 0.8499099926873099 0.533040744016028 0.06622238398574912 3.267328186840369e-07 3.5542373966352174e-08 0.06411967847672898 0.021373182526913243 6.122621566298164e-11 10.213062583083879 -0.15009031333099965 GFEVVYMTEPIDEYCVQQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFEVVYMTEPIDEYCVQQLK 20 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 25618000.0 25618000.0 0.0 0.0 False True 21302502.069827244 0.0 0.0 1.0 0.0 0.0 24.34451955530747 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 GFEVVYMTEPIDEYCVQQLK(ub)EFDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFEVVYMTEPIDEYCVQQLKEFDGK 25 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 31722200.0 7938200.0 10270000.0 13514000.0 True False 10276156.385315593 9698465.471944451 11054590.665349614 1.0 0.9437833668825194 1.075751501908475 23.292797415051666 -6.790979115281135 1.4925699767000664 0.9686198808236421 1.0771899316768243 0.8044161682915987 0.02391333793827338 0.23390714830770418 1.0294315033482726 0.012610491483692702 0.029501409530896673 1.6181578511098383e-07 6.790979115281135 0.10857005085318217 GFFDPNTEENLTYLQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFFDPNTEENLTYLQLK 17 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 4681900.0 0.0 1859600.0 2822300.0 False True 0.0 1777436.7231251462 2155730.8670930546 0.0 GFFDPNTEENLTYLQLK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFFDPNTEENLTYLQLKER 19 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 27510600.0 6624000.0 7096600.0 13790000.0 True False 6413724.745794287 9930309.388280094 10177985.308867658 1.0 1.5482905459564287 1.5869070956844122 22.612731009103317 -11.528966982166885 0.43659359579062146 2.2751524992942775e-08 1.5877072445628608 0.9997529207722716 0.004213135945485605 4.125648847374183 0.21692560588422158 3.898768546639058 0.008985104017131623 2.958237362051664e-12 11.528966982166885 1.587707221811336 GFFDPNTEENLTYLQLK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFFDPNTEENLTYLQLKER 19 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 254781000.0 11347000.0 47514000.0 195920000.0 True False 17214228.576817375 39034755.47142354 157196326.12521347 1.0 2.267586682565151 9.131767097417994 24.037098194911028 -6.938042802946599 0.677527648240633 0.9197199822734392 10.880886825334413 0.9978961310169603 0.16385225672210468 0.08867103099030026 0.05876168288080859 0.15722484755322777 0.5960604870056929 1.1533395820379838e-07 6.938042802946599 9.961166843060973 GFFDPNTEENLTYLQLK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFFDPNTEENLTYLQLKER 19 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 10202900.0 2238300.0 2461300.0 5503300.0 True False 3065859.9977831077 2352551.6275693304 4203533.884021254 1.0 0.7673382441698045 1.3710782250529336 21.547860387287706 -6.802249414235776 1.4469106919141974 0.8719944707869459 1.3798632805280653 0.8386022151468282 0.09988372901594365 0.21756503492998602 0.8990186606505809 0.054304008414553746 0.12611071949672423 1.576705511601372e-07 6.802249414235776 0.5078688097411194 GFFDPNTEENLTYLQLK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFFDPNTEENLTYLQLKER 19 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 27649000.0 6624000.0 10753000.0 10272000.0 True False 5508149.49295557 10695071.454696612 12419827.70763818 1.0 1.941681406500432 2.254809482480827 22.393136284537594 -10.369278982718754 0.24374750458591773 6.819423857803953e-11 2.429996373852511 0.9991669263446297 0.015391682487210716 1.9607107238414734 0.11859830738752472 1.3764488987707861 0.14663161970832 4.272883158839332e-11 10.369278982718754 2.429996373784317 GFFEGTIASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFFEGTIASK 10 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 11323000.0 4578500.0 0.0 6744500.0 False True 6002457.838257078 0.0 6046643.837812323 1.0 0.0 1.007361317771134 22.517121934210344 -12.043037880803633 18.015240868366522 0.8778840482594596 0.5533125929970228 0.0 0.4871155611054147 0.0 0.0 0.0 0.139824465702274 9.056536029280373e-13 12.043037880803633 -0.3245714552624368 GFFEGTIASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFFEGTIASK 10 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 13084000.0 4578500.0 5104000.0 3401500.0 False True 6271295.179310186 4878488.403329078 2598135.7560914913 1.0 0.7779076353197092 0.41429013972473777 22.580331995733236 -6.963761674943759 0.37870571090313637 1.025343345501515 0.15402238822787756 0.9998852962975048 0.0025857111221168267 0.07838374058175339 0.01635740324349485 0.004738625047473008 0.030744545501599413 1.0870219781996404e-07 6.963761674943759 -0.8713209572736376 down GFFICDQPYEPVSPYSCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFFICDQPYEPVSPYSCK 18 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 16135000.0 2547200.0 7521100.0 6066700.0 False True 3339403.867119888 6398981.197018184 5438976.079895616 1.0 1.9162046435961841 1.628726651917826 21.671159152649246 -10.019193595899202 4.898158330614167 0.9999881868150616 1.772465647768419 0.905899459173739 0.11736239868940945 15632625.704208935 31976569.22229865 1262.3195002118382 0.04017627382034524 9.567674769950288e-11 10.019193595899202 0.7724774609533575 GFFICDQPYEPVSPYSCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFFICDQPYEPVSPYSCK 18 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 15350500.0 2547200.0 6401400.0 6401900.0 False True 3488968.6754917298 6118564.981401012 4889903.071269186 1.0 1.7536887116186766 1.4015325232405564 21.734369214172137 -10.29783345277745 5.699847890609985 0.9999425364245138 1.5776106174296218 0.7819953533883552 0.1437671618816565 0.00010499315281233149 1.293416933565998e-05 0.1392157227511177 0.046400651974927376 5.036937328374839e-11 10.29783345277745 0.577668081005108 GFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEK 34 1 Q9UL12;Q9UL12-2;A0A0A0MT55;Q5SYV1 Q9UL12 SARDH Sarcosine dehydrogenase, mitochondrial 0 69005000.0 12245000.0 18961000.0 37799000.0 False True 18576560.229411207 15577261.407030838 30328011.082109768 1.0 0.8385439077342343 1.6325956316763723 24.146980050787224 -6.853757047015891 1.2168015153244223 0.9134780226097174 1.6667190800891518 0.945596472299591 0.07992472776409028 0.15337496938850467 0.4351055309301462 0.0513432222892464 0.119134224513662 1.400370498641679e-07 6.853757047015891 0.7532410574794344 GFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFFLGCGFNSAGMMLGGGCGQELAHWIIHGRPEK 34 1 Q9UL12;Q9UL12-2;A0A0A0MT55;Q5SYV1 Q9UL12 SARDH Sarcosine dehydrogenase, mitochondrial 0 25639300.0 12245000.0 6474600.0 6919700.0 False True 15851393.885035563 6114282.81836919 5660385.602117794 1.0 0.38572524679620457 0.3570907166379516 23.918106372879674 -13.598977492078467 0.4409119342668642 9.999311598362166 0.3568512280344417 0.9998830676432037 0.0032067635948909525 23.293090630294927 0.22415570316895075 200.86566367761532 0.006603665652048583 2.5178074132832274e-14 13.598977492078467 -9.642460370327724 GFFNIYHPLDPVAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFFNIYHPLDPVAYR 15 0 Q9Y6Y8;Q9Y6Y8-2 Q9Y6Y8 SEC23IP SEC23-interacting protein 0 8544500.0 2559000.0 3205100.0 2780400.0 False True 3354873.7813912523 2726911.573381946 2492710.87948008 1.0 0.8128209140109905 0.7430118215792796 21.677827059032406 -13.999999999999998 0.13694432252712238 1.8920070248597975 0.6533542709982556 0.9996153902399004 0.0021278566956964245 11.932143142930679 0.115710171331858 2.849515817494234 0.07999963436880449 1.0000000000000041e-14 13.999999999999998 -1.238652753861542 GFFNIYHPLDPVAYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFFNIYHPLDPVAYR 15 0 Q9Y6Y8;Q9Y6Y8-2 Q9Y6Y8 SEC23IP SEC23-interacting protein 0 11699500.0 3699400.0 2410400.0 5589700.0 False True 3581964.5719491825 3372885.290069948 4125589.8825944546 1.0 0.9416299972600062 1.1517673611019132 21.77231963748948 -6.832617857376488 1.3163610447266434 0.9688642717903252 1.1577226939026348 0.9109741987618304 0.02642610707479013 0.17760501439726403 0.6009867526684267 0.01575852260842447 0.03626108131851178 1.4702193780700663e-07 6.832617857376488 0.18885842211230963 GFFNIYHPLDPVAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFFNIYHPLDPVAYR 15 0 Q9Y6Y8;Q9Y6Y8-2 Q9Y6Y8 SEC23IP SEC23-interacting protein 0 15463800.0 2559000.0 4257000.0 8647800.0 False True 3505131.4543747413 4068911.6639835127 6605367.747031613 1.0 1.160844241349385 1.884485028025833 21.741037120555298 -6.942185714390376 0.6389138909582471 0.9920837825779331 2.0928454650170956 0.9984363142594007 0.015211764056071135 0.08678364818457993 0.05017550639180419 0.015065260356649011 0.061707521932501765 1.1423897179934677e-07 6.942185714390376 1.1007616824391624 GFFNIYHPLDPVAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFFNIYHPLDPVAYR 15 0 Q9Y6Y8;Q9Y6Y8-2 Q9Y6Y8 SEC23IP SEC23-interacting protein 0 8452200.0 3699400.0 2067100.0 2685700.0 False True 3076215.0112077044 2055964.1220127738 3247267.4527262338 1.0 0.6683421394545546 1.0556048393546376 21.552724912923757 -6.6800108708302 1.9021826917193878 0.7901521222733051 1.0541183803207155 0.32400886070443213 0.14056515402831485 0.4385090641069988 3.067749320373544 0.0592998845241607 0.15637815796322418 2.0892438343129407e-07 6.6800108708302 0.26396625804741036 GFFSFFQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFFSFFQR 8 0 H7C1G2;A0A0B4J1Z0;A0A0X1KG75;A0A590PXD8;A0A0D9SG04;Q53SF7;Q53SF7-3;Q53SF7-2 H7C1G2 COBLL1 Cordon-bleu protein-like 1 0 4570200.0 1027600.0 1516800.0 2025800.0 False True 1347193.5512925563 1290499.3524400934 1816189.6488457548 1.0 0.9579168124742966 1.3481282233746021 20.361525707006415 -6.880196316527516 1.078666345019339 0.9738471251795779 1.3758907250759818 0.9738450429776806 0.028281536182062698 0.12745804555942544 0.2712159495366084 0.020192967672690184 0.04885773274684395 1.3176609743630206e-07 6.880196316527516 0.4020435998964038 GFFSFFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFFSFFQR 8 0 H7C1G2;A0A0B4J1Z0;A0A0X1KG75;A0A590PXD8;A0A0D9SG04;Q53SF7;Q53SF7-3;Q53SF7-2 H7C1G2 COBLL1 Cordon-bleu protein-like 1 0 3184500.0 1631700.0 795340.0 757460.0 False True 1579902.5766474244 1112923.4096433069 559058.502687085 1.0 0.7044253399503569 0.35385631427566566 20.5914041679031 -7.030856754251431 0.29265359383044615 1.0689144589952757 8.679963183965253e-14 0.9999697518711103 0.0014525229806540438 0.0725554097399506 0.010774135842847556 0.006227896190857203 0.030389208885602197 9.314150385769045e-08 7.030856754251431 -1.0689144589951889 down GFFSFFQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFFSFFQR 8 0 H7C1G2;A0A0B4J1Z0;A0A0X1KG75;A0A590PXD8;A0A0D9SG04;Q53SF7;Q53SF7-3;Q53SF7-2 H7C1G2 COBLL1 Cordon-bleu protein-like 1 0 5403700.0 1027600.0 1638000.0 2738100.0 False True 1407531.4898458323 1565627.7438583525 2091417.1729396184 1.0 1.1123216461962329 1.4858759381423803 20.424735768529306 -6.949114036864935 0.5684967738538854 0.9953146775099164 1.620997698224364 0.9991298378030667 0.006126686513247049 0.08384365657798673 0.03745131567128647 0.006502035732640637 0.031112963065403447 1.1243097144255516e-07 6.949114036864935 0.6256830207144475 GFFSFFQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFFSFFQR 8 0 H7C1G2;A0A0B4J1Z0;A0A0X1KG75;A0A590PXD8;A0A0D9SG04;Q53SF7;Q53SF7-3;Q53SF7-2 H7C1G2 COBLL1 Cordon-bleu protein-like 1 0 3750800.0 1631700.0 900800.0 1218300.0 False True 1356830.8465663653 895947.2116051998 1473040.897217249 1.0 0.6603234396332522 1.0856481491005074 20.371809443337376 -6.69397569931319 1.8520011537013403 0.7878459824643868 1.0842643723348686 0.3892078130914445 0.14354512172932032 0.4081887106107089 2.717360197894002 0.061931250429987254 0.1604868435570015 2.0231323786679722e-07 6.69397569931319 0.29641838987048186 GFGDGYNGYGGGPGGGNFGGSPGYGGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGDGYNGYGGGPGGGNFGGSPGYGGGR 28 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 46070400.0 4087400.0 24668000.0 17315000.0 False True 5358620.982437903 20987630.55511089 15523409.897208141 1.0 3.9166103786580133 2.896903876591356 22.353430346542492 -10.52031933044646 5.855504837592797 0.9962618985047569 3.4067571276240134 0.8813433123426764 0.4162934362436024 0.020295059225748972 0.001662561511093689 0.4026707381341482 0.13435812880891032 3.01773200977407e-11 10.52031933044646 2.4104952291192565 GFGDGYNGYGGGPGGGNFGGSPGYGGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGDGYNGYGGGPGGGNFGGSPGYGGGR 28 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 29647500.0 8215900.0 3475600.0 17956000.0 False True 7955090.751656296 4863425.205014562 13252784.931546612 1.0 0.6113601160366359 1.6659501877822456 22.923446958235957 -6.806933142646271 1.4272617389614812 0.7874115284681121 1.683155121796334 0.8516978737611715 0.16769876395196784 0.2110133824163025 0.847732927002267 0.09240111378171899 0.21406727737947986 1.5597926062218134e-07 6.806933142646271 0.895743593328222 GFGDGYNGYGGGPGGGNFGGSPGYGGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGDGYNGYGGGPGGGNFGGSPGYGGGR 28 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 39249400.0 4087400.0 17858000.0 17304000.0 False True 5598622.237831694 17068974.511491083 13217151.587066637 1.0 3.0487812512425867 2.3607864623824923 22.416640408065383 -10.153008335584566 5.4152797586311845 0.9999558457504246 2.704783856812974 0.8911465847225902 0.28087269640170553 0.0001497326754770069 2.3419510659993774e-05 0.2719607777486223 0.09065127296379398 7.03058825670157e-11 10.153008335584566 1.704828011062549 GFGDGYNGYGGGPGGGNFGGSPGYGGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGDGYNGYGGGPGGGNFGGSPGYGGGR 28 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 11681890.0 8215900.0 2487300.0 978690.0 False True 6831884.876082983 2473900.4212096054 1183329.5540487175 1.0 0.3621109644089905 0.17320689319448426 22.703852233670233 -13.999999999999762 0.17057028040819952 4.221722999480037 0.007579518827668713 0.9995126016591889 0.007809503076546186 12.097138341315747 0.1307957900206428 12.896085986558182 0.15321536490369922 1.0000000000005481e-14 13.999999999999762 -4.2141434806523685 GFGDGYNGYGGGPGGGNFGGSPGYGGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGDGYNGYGGGPGGGNFGGSPGYGGGR 28 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 12704100.0 2851500.0 4361800.0 5490800.0 False True 3691322.961468269 4119061.995669643 4491530.7403656775 1.0 1.1158768925575766 1.2167807550979273 21.815706536798043 -6.972745734273124 0.18095492464974353 0.9229762201398335 1.4124126555263417 0.9999966321023186 0.0001624409216369946 0.07542140332122094 0.005712860774322403 0.0038530384189902054 0.011290945164137088 1.0647662228270949e-07 6.972745734273124 0.48943643538650816 GFGDHIHWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGDHIHWR 9 0 O95881;V9GY50;V9GYV4 O95881 TXNDC12 Thioredoxin domain-containing protein 12 0 11560200.0 3053500.0 2387200.0 6119500.0 False True 4003168.070136065 2031039.065232721 5486312.842388986 1.0 0.5073579299316522 1.3704927563040112 21.93271075683621 -6.7519081679940225 1.6428671914247173 0.7109823667218966 1.3724507934692254 0.6570843754319492 0.20703390165164515 0.2967403320156454 1.5763629528293406 0.09952777682957681 0.24113643679796082 1.770483289215897e-07 6.7519081679940225 0.6614684267473288 GFGDHIHWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGDHIHWR 9 0 O95881;V9GY50;V9GYV4 O95881 TXNDC12 Thioredoxin domain-containing protein 12 0 7532700.0 1273200.0 1075200.0 5184300.0 False True 1232782.9629144457 1504532.9670939262 3826376.304333765 1.0 1.2204362100665564 3.1038523563691665 20.23348739835255 -6.9288926412248655 0.7558250424341323 0.9701509322575397 3.4798273746020727 0.9963161022786813 0.0573026919226375 0.09321700395123518 0.08052673810364566 0.05186563332363203 0.17146627963352734 1.1778971168991632e-07 6.9288926412248655 2.5096764423445332 up GFGDHIHWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGDHIHWR 9 0 O95881;V9GY50;V9GYV4 O95881 TXNDC12 Thioredoxin domain-containing protein 12 0 10010400.0 3053500.0 2224100.0 4732800.0 False True 4182461.4677347695 2125831.9078848315 3615010.115075649 1.0 0.508272921169597 0.8643259819518545 21.995920818359103 -9.860197929533513 5.6917103906295825 1.0000001021155758 0.6862994515597913 0.5085992180025978 0.14535805338209185 49375704.06416189 85537405.12026978 43.00920800406119 0.04975993247046944 1.3797552983720922e-10 9.860197929533513 -0.31370065055578444 GFGDHIHWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGDHIHWR 9 0 O95881;V9GY50;V9GYV4 O95881 TXNDC12 Thioredoxin domain-containing protein 12 0 4002500.0 1273200.0 1505400.0 1223900.0 False True 1058722.2123235257 1497290.1114014941 1479811.8313257769 1.0 1.4142426539965238 1.3977338097763212 20.013892673786827 -10.073319193092756 4.420042960385423 0.9999677694084267 1.4059882319108066 0.9987614036473943 0.006739707546529513 1017280.637618191 1161489.9748965614 256.32841470134423 0.0023071812418000597 8.446578194407258e-11 10.073319193092756 0.4060204625023799 GFGDHIHWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGDHIHWR 9 0 O95881;V9GY50;V9GYV4 O95881 TXNDC12 Thioredoxin domain-containing protein 12 0 11543200.0 2541200.0 2598400.0 6403600.0 False True 3289633.494540821 2453796.75582283 5238210.506484596 1.0 0.7459179753291453 1.5923386344337318 21.64949542834176 -6.826231250308203 1.3447161126435283 0.8638439013165536 1.613403019213762 0.8981143564636518 0.11319566793237072 0.18550868008518642 0.6573677756006082 0.0661184381353044 0.1521984003308103 1.4919997476833885e-07 6.826231250308203 0.7495591178972084 GFGDLK(ub)SPAGLQVLNDYLADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGDLKSPAGLQVLNDYLADK 21 1 P24534;C9JZW3;F2Z2G2;F8WF65 P24534 EEF1B2 Elongation factor 1-beta 1 13866600.0 5189300.0 3068800.0 5608500.0 True False 5024568.511979211 4294187.843580583 4139465.5986065473 1.0 0.8546381312828539 0.8238449906171116 22.260568278579708 -13.999999999999838 0.21812257024929402 1.8700257231593094 0.8070744085394269 0.9994960773870006 0.0017244150243276891 12.949277809702775 0.147969448246589 4.847972280196099 0.0172552594375237 1.0000000000003722e-14 13.999999999999838 -1.0629513146198826 GFGDLK(ub)SPAGLQVLNDYLADK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFGDLKSPAGLQVLNDYLADK 21 1 P24534;C9JZW3;F2Z2G2;F8WF65 P24534 EEF1B2 Elongation factor 1-beta 1 28434800.0 7177600.0 13840000.0 7417200.0 True False 10888943.952847844 11370143.867586432 5951187.168925758 1.0 1.0441916054322915 0.5465348333774197 23.376360707534793 -6.885241865808572 1.050094082486054 1.0298684327637229 0.5075145072336408 0.9776749590324489 0.033604532178047486 0.12308976911070772 0.2450664004020077 0.024522585480652594 0.06017794734320551 1.302441225288929e-07 6.885241865808572 -0.5223539255300821 GFGDLK(ub)SPAGLQVLNDYLADK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGDLKSPAGLQVLNDYLADK 21 1 P24534;C9JZW3;F2Z2G2;F8WF65 P24534 EEF1B2 Elongation factor 1-beta 1 12264100.0 5189300.0 4177400.0 2897400.0 True False 4315132.8749689525 4154895.5170510174 3503232.9439360267 1.0 0.9628661822101856 0.8118482200762434 22.040973554013984 -6.9444940017545465 0.616339090363171 1.0016578300570962 0.7651060177197173 0.9986952337300744 0.0029391244787806774 0.08577496610931883 0.04571372362706169 0.002969889734168751 0.012763287600998175 1.1363339920024122e-07 6.9444940017545465 -0.23655181233737888 GFGDLK(ub)SPAGLQVLNDYLADK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGDLKSPAGLQVLNDYLADK 21 1 P24534;C9JZW3;F2Z2G2;F8WF65 P24534 EEF1B2 Elongation factor 1-beta 1 19755600.0 7177600.0 12578000.0 0.0 True False 9291544.69164812 11878023.2430494 0.0 1.0 1.278369058884922 0.0 23.147487029627243 -6.8893542764402795 1.320281193660233 1.1450258025373186 1.6296731365977823e-17 0.938604587553258 0.13600938288298886 0.14189838500631854 0.49693892837775266 0.08382789183577391 0.1690344091964589 1.2901663888649535e-07 6.8893542764402795 -1.1450258025373186 down GFGDPFSGK(ub)DPFVPSSAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGDPFSGKDPFVPSSAAK 19 1 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 27531300.0 7174300.0 10070000.0 10287000.0 True False 6946555.773513275 14091003.51435625 7592526.096615049 1.0 2.0284877821155987 1.0929914542059553 22.72786641045237 -6.623557105164364 2.103620740261524 1.680721233459622 1.0966269019982655 0.09488231201857322 0.4418855505818705 0.5759541873414468 4.84796847735494 0.1723050206094456 0.4898265248524042 2.3792654319648665e-07 6.623557105164364 -0.5840943314613565 GFGDPFSGK(ub)DPFVPSSAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGDPFSGKDPFVPSSAAK 19 1 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 20844900.0 7093000.0 7569200.0 6182700.0 True False 9715473.781117642 7234767.716002829 4722473.59670348 1.0 0.7446644269746113 0.48607754012797294 23.21185292077066 -6.970967870807027 0.2339191894910524 1.100143245233673 0.12317507258546155 0.9999889775563252 0.000696544545641435 0.07598988560456289 0.007897610327022577 0.006456559092653812 0.02549138351514426 1.0691339710428554e-07 6.970967870807027 -0.9769681726482115 down GFGDPFSGK(ub)DPFVPSSAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGDPFSGKDPFVPSSAAK 19 1 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 20254600.0 7174300.0 9808500.0 3271800.0 True False 5965748.325379095 9755659.663665196 3955918.2529060175 1.0 1.6352784481643834 0.6631051189466055 22.508271685886648 -6.730400800204427 1.7219666024680018 1.3821393273825777 0.6636612940323066 0.5610535715095631 0.2670469213184075 0.3354782129394997 1.9490287135245379 0.12289300466279944 0.304789359221351 1.860369452789023e-07 6.730400800204427 -0.7184780333502712 GFGDPFSGKDPFVPSSAAK(ub)PSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGDPFSGKDPFVPSSAAKPSK 22 2 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 34682000.0 11416000.0 11330000.0 11936000.0 True False 14966486.552701272 9639608.163994085 10700977.218196744 1.0 0.644079566039115 0.7149959464778556 23.835232246468724 -10.817249501844529 7.223314140121405 1.0153360180728979 0.6795377562584852 0.9645728907401696 0.028951491080000787 0.007035285504145503 0.0001779931272685151 0.027581405680577507 0.009344053566726308 1.5231774381251394e-11 10.817249501844529 -0.33579826181441264 GFGDPFSGKDPFVPSSAAK(ub)PSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGDPFSGKDPFVPSSAAKPSK 22 2 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 35092000.0 11416000.0 10988000.0 12688000.0 True False 15636803.705799948 10502513.827543085 9691355.717562497 1.0 0.6716534929480205 0.6197785621602331 23.898442307991616 -13.999999999999998 0.25972611076462127 3.400223958293446 0.6007688162710842 0.9995617746997949 0.0035241731701962822 14.404977037787422 0.1612715696378314 18.143944172082694 0.022711710959685685 1.0000000000000041e-14 13.999999999999998 -2.799455142022362 GFGDPFSGKDPFVPSSAAK(ub)PSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGDPFSGKDPFVPSSAAKPSK 22 2 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 61839300.0 24551300.0 25912000.0 11376000.0 True False 31782141.82847475 24469974.421521388 9305684.727617083 1.0 0.769928425641782 0.29279602293133655 24.921713016751884 -6.959329470463182 0.4447824958060266 1.0162340449883613 0.027739187656151777 0.999744517464031 0.004707694505310735 0.07994151588770737 0.022022894284161796 0.006330052035285776 0.039499483422101085 1.098172412654317e-07 6.959329470463182 -0.9884948573322095 down GFGDVGEAK(ub)GGSTTGSQFLEQFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFGDVGEAKGGSTTGSQFLEQFK 23 1 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 1 123008000.0 16600000.0 28975000.0 77433000.0 True False 25183413.62255826 23804184.86729169 62128333.60991048 1.0 0.9452326528905869 2.467033839854756 24.585970518457533 -6.898552208112449 0.9703887633590572 0.934191163208103 2.6221503660185443 0.9858317473351217 0.08389623286881102 0.1124783708412183 0.18349705222895596 0.06501611750529739 0.16796251734706158 1.2631292493386194e-07 6.898552208112449 1.6879592028104413 up GFGFGGFAISAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGFGGFAISAGK 13 0 Q86XP3;J3QRI2;J3KTK9 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 29049400.0 7579200.0 9311200.0 12159000.0 False True 9936404.597077213 7922005.254773333 10900903.317363774 1.0 0.797270801261815 1.0970671746368166 23.24429248868699 -6.724558754857983 1.7428401891957703 0.8772666096625953 1.0967264079693555 0.5339625743518159 0.08526507836594091 0.3465381902050996 2.0594513648294455 0.03880915199794467 0.09690965041721997 1.8855638579574214e-07 6.724558754857983 0.2194597983067602 GFGFGGFAISAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGFGGFAISAGK 13 0 Q86XP3;J3QRI2;J3KTK9 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 38615800.0 13573000.0 8319800.0 16723000.0 False True 13142132.544484586 11641939.527183848 12342744.620753711 1.0 0.8858485856672987 0.9391736522953912 23.64769606176839 -10.129736809340766 4.500122504416297 1.0000106086894989 0.9125111189786078 0.7820908019981899 0.02176986729909825 2.317377722156922e-06 4.4813605242009294e-07 0.021081139043402197 0.0070261944569056075 7.417596254633258e-11 10.129736809340766 -0.08749948971089105 GFGFGGFAISAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGFGGFAISAGK 13 0 Q86XP3;J3QRI2;J3KTK9 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 36092200.0 7579200.0 11357000.0 17156000.0 False True 10381435.060178604 10855210.187423257 13104106.13891096 1.0 1.0456367664487902 1.26226346000815 23.307502550209882 -6.940971141274383 0.650466522857233 0.9976033101055887 1.3223883332439874 0.9982883495632356 0.004733079364880252 0.08732636308103893 0.052613036114919604 0.004641933339133648 0.018566293966788786 1.1455890629331858e-07 6.940971141274383 0.32478502313839874 GFGFGGFAISAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGFGGFAISAGK 13 0 Q86XP3;J3QRI2;J3KTK9 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 33623300.0 13573000.0 8173300.0 11877000.0 False True 11286550.885852352 8129268.810626965 14360425.78695664 1.0 0.7202615655431964 1.2723484731688384 23.428101337202666 -6.7689616749735775 1.57839929756668 0.8393331108681205 1.2753332682246938 0.7265498437408555 0.11786473364995077 0.26813012750070286 1.3181688739586643 0.05886445706892958 0.1402573895821795 1.7023087247826992e-07 6.7689616749735775 0.4360001573565734 GFGFGGFAISAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGFGGFAISAGK 13 0 Q86XP3;J3QRI2;J3KTK9 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 48753000.0 11209000.0 22357000.0 15187000.0 False True 14510271.462422518 21112813.296617538 12423121.831779249 1.0 1.455025383315104 0.8561605386881704 23.790571174231445 -6.703562270089156 1.818140979913764 1.2815621394980463 0.8578171628914975 0.43448857073349356 0.19194990400561168 0.3881698079649519 2.497010265109841 0.08414721720968005 0.21545992691743263 1.9789632528309872e-07 6.703562270089156 -0.42374497660654886 GFGFGLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGFGLVK 8 0 A0A0A0MR02;P45880-2;P45880;P45880-1;Q5JSD2;Q5JSD1;A2A3S1 A0A0A0MR02 VDAC2 Voltage-dependent anion-selective channel protein 2 0 19038100.0 5051400.0 4114000.0 9872700.0 False True 6622434.317827177 3500207.2362463987 8851167.709625585 1.0 0.5285378560605819 1.3365429213542817 22.658930199151246 -6.748550321100157 1.655270342550593 0.7222901107778745 1.337966172788155 0.6426698097917753 0.1980989340439635 0.3025880980257601 1.630747059379828 0.09455965131989853 0.22991033671803404 1.7842252408551566e-07 6.748550321100157 0.6156760620102806 GFGFGLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGFGLVK 8 0 A0A0A0MR02;P45880-2;P45880;P45880-1;Q5JSD2;Q5JSD1;A2A3S1 A0A0A0MR02 VDAC2 Voltage-dependent anion-selective channel protein 2 0 7590040.0 2901300.0 925740.0 3763000.0 False True 2809199.819591328 1295392.8096703242 2777357.412419794 1.0 0.4611251932440937 0.9886649547143406 21.421727816957066 -10.92370121052804 10.726909749276889 1.0417876682568055 0.7248950739792172 0.26610768320394773 0.21536720577194235 0.12015434092114434 0.0008546372223958925 0.1164127020582502 0.06950946677282989 1.1920618504418832e-11 10.92370121052804 -0.3168925942775883 GFGFGLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGFGLVK 8 0 A0A0A0MR02;P45880-2;P45880;P45880-1;Q5JSD2;Q5JSD1;A2A3S1 A0A0A0MR02 VDAC2 Voltage-dependent anion-selective channel protein 2 0 11774100.0 5051400.0 2940000.0 3782700.0 False True 6919039.0889521465 2810101.0787201137 2889304.167151932 1.0 0.40614036755582045 0.4175874901133855 22.722140260674138 -10.040129244202374 5.447915217113374 1.0000034688322876 0.4118639288340781 0.9997159625623272 0.004673268216701072 12934861.603274753 0.004315910124192648 562.8329289202705 0.001599784011941037 9.117394691658235e-11 10.040129244202374 -0.5881395399982096 GFGFGQGAGALVHSE ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGFGQGAGALVHSE 15 0 P21291;E9PP21 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 98259000.0 22995000.0 27335000.0 47929000.0 False True 30146667.683896784 23256724.550995477 42969766.84743223 1.0 0.7714525795969929 1.425357100757941 24.845495204260256 -6.812268312178912 1.404851724736355 0.875772643818869 1.4374144210063775 0.8656994697818589 0.0992972939360991 0.2037214396014762 0.791977316072092 0.055569006329658055 0.12842311710864973 1.5407482666560456e-07 6.812268312178912 0.5616417771875085 GFGFGQGAGALVHSE ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGFGQGAGALVHSE 15 0 P21291;E9PP21 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 69402500.0 19146000.0 6205500.0 44051000.0 False True 18538220.70999056 8683388.511254998 32512721.598326977 1.0 0.46840463532594434 1.7538210439368285 24.14399944560446 -6.794403566368665 1.478738099405841 0.7045808669341398 1.7691898315091605 0.8152560757808315 0.2266762274102448 0.22885358111799592 0.9884526621856005 0.12062979483619413 0.281539798369627 1.6054487030150963e-07 6.794403566368665 1.0646089645750207 GFGFGQGAGALVHSE ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFGFGQGAGALVHSE 15 0 P21291;E9PP21 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 100628000.0 0.0 89515000.0 11113000.0 False True 0.0 73540348.86611283 8916510.67899906 0.0 GFGFGQGAGALVHSE ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGFGQGAGALVHSE 15 0 P21291;E9PP21 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 68431000.0 22995000.0 21933000.0 23503000.0 False True 31496872.916509263 20963927.537268143 17952075.459479135 1.0 0.6655875836575441 0.5699637391643871 24.908705265783148 -13.999999999999998 0.17558021263433762 2.712498812440564 0.49043522349459273 0.9995041399215343 0.004105371208860705 12.150771346928126 0.13278456506397412 7.092419745731286 0.07417147535937542 1.0000000000000041e-14 13.999999999999998 -2.222063588945971 GFGFGQGAGALVHSE ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGFGQGAGALVHSE 15 0 P21291;E9PP21 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 40181000.0 19146000.0 10673000.0 10362000.0 False True 15920747.311613433 10615502.430575376 12528646.291525202 1.0 0.6667716171107037 0.7869383293575765 23.924404721038737 -10.276745051655602 5.153490077353668 1.0000511804835233 0.7268549736568761 0.8732414214927594 0.04905785484565496 2.885352870192017e-05 4.049347487950309e-06 0.04750894638642457 0.015833354568127237 5.287555614849824e-11 10.276745051655602 -0.27319620682664714 GFGFILFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGFILFK 8 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 589000000.0 164470000.0 195150000.0 229380000.0 False True 215621762.72974548 166034380.68874195 205645957.9683286 1.0 0.7700260798667387 0.9537347036072593 27.683927555917407 -9.940834684370941 5.567830580728086 1.0000001749855938 0.8618803918509267 0.4297724197539765 0.07499873158641752 1.6289758320506176e-07 3.109529932160401e-08 0.07261730158142617 0.024205736534945 1.145949067731642e-10 9.940834684370941 -0.1381197831346671 GFGFILFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGFILFK 8 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 445982750.0 184860000.0 108792750.0 152330000.0 False True 178991720.48724815 152234262.42169645 112430203.19795567 1.0 0.8505100795013701 0.6281307475669831 27.41531761425186 -6.965395034167114 0.3512080233949364 1.0211937819443957 0.44992924969836146 0.9999210555202578 0.001357484314649051 0.07782718518849276 0.014388813309496663 0.0030432542695208527 0.01909890010867524 1.0829414226032219e-07 6.965395034167114 -0.5712645322460342 GFGFILFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFGFILFK 8 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 464300000.0 127050000.0 128620000.0 208630000.0 False True 192744138.5991581 105666756.0873533 167394189.05422264 1.0 0.5482229283615416 0.8684787525619407 27.52211174716396 -10.256577823815455 5.368588708526543 1.0000297668465399 0.7083508404617156 0.5251150854267674 0.13074389274099985 4.658659932175987e-05 6.451098428894235e-06 0.1266051330936589 0.04219740993367188 5.538882805043686e-11 10.256577823815455 -0.2916789263848243 GFGFILFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGFILFK 8 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 632803710.0 164470000.0 169693710.0 298640000.0 False True 225279003.634628 162196080.79014236 228107382.6838637 1.0 0.7199786849785718 1.012555005142969 27.7471376174403 -11.05292202795175 11.406627240657834 1.5369093162643475 0.866266845057419 0.21787787900943623 0.11944378253732305 0.04235245553416437 0.00019649811731142278 0.0030033453740394285 0.03855031504792272 8.852745353424436e-12 11.05292202795175 -0.6706424712069284 GFGFILFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGFILFK 8 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 342438200.0 184860000.0 63118000.0 94460200.0 False True 153719280.68655896 62777970.80605786 114211391.08538218 1.0 0.4083936024529361 0.7429867650647203 27.195722889686138 -10.223839748663485 5.709775169569581 1.0000157029970267 0.5756901837588518 0.681956810205284 0.13659708663719297 2.73061456107653e-05 3.7118460806905034e-06 0.1322644503138217 0.04408652014051997 5.97255628680228e-11 10.223839748663485 -0.42432551923817485 GFGFILFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGFILFK 8 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 506704900.0 127050000.0 221450000.0 158204900.0 False True 164468729.52991146 209126112.8298051 129413231.5193555 1.0 1.2715250700089584 0.7868561512528708 27.29323806925641 -6.754649034231887 1.6323438949356182 1.1587578793305855 0.7855219379231478 0.6688739574552474 0.11413370702701787 0.29199079521958043 1.5320240696037004 0.055199390595751095 0.1333773002778572 1.7593448163922643e-07 6.754649034231887 -0.37323594140743765 GFGFITFTNPEHASVAMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 GFGFITFTNPEHASVAMR 18 0 P98179 P98179 RBM3 RNA-binding protein 3 0 28535800.0 8291500.0 12777400.0 7466900.0 False True 10870236.795000225 10871061.725915112 6694296.815562435 1.0 1.0000758889553598 0.6158372574405632 23.373880032290796 -6.906849221373096 0.9169313177252092 1.0131144330041164 0.5693884107761074 0.9896770662661059 0.01840150886338646 0.10653837992664894 0.15034486573293715 0.014834692033889822 0.04010899302423135 1.239226747363095e-07 6.906849221373096 -0.44372602222800905 GFGFITFTNPEHASVAMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 GFGFITFTNPEHASVAMR 18 0 P98179 P98179 RBM3 RNA-binding protein 3 0 46085100.0 17322600.0 9456200.0 19306300.0 False True 16772703.544911847 13232109.973431565 14249400.853414912 1.0 0.7889074017197214 0.8495589763009672 23.99961191581348 -9.856176856607727 5.822851657428803 1.000000039519024 0.8192331890100206 0.9221415678934335 0.024760901637882714 1.268621139157372e-08 2.5154779654467305e-09 0.023974644921140875 0.007991546639882444 1.3925895868394061e-10 9.856176856607727 -0.18076685050900343 GFGFITFTNPEHASVAMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GFGFITFTNPEHASVAMR 18 0 P98179 P98179 RBM3 RNA-binding protein 3 0 86401700.0 19279400.0 40626600.0 26495700.0 False True 29248259.312936727 33376465.812925424 21258813.28152212 1.0 1.1411436645107547 0.7268402900175049 24.80184743060601 -6.814765427480151 1.3943083678791635 1.0765024801947394 0.7187680201851637 0.8719215958770236 0.06154723190701376 0.20037880496074137 0.766806009441838 0.03469895941504437 0.08011065083215703 1.531914660896696e-07 6.814765427480151 -0.35773446000957565 GFGFITFTNPEHASVAMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GFGFITFTNPEHASVAMR 18 0 P98179 P98179 RBM3 RNA-binding protein 3 0 48140800.0 8291500.0 15488200.0 24361100.0 False True 11357091.619362319 14803880.11137175 18607509.91260341 1.0 1.303492179822968 1.6384044908892081 23.437090093813687 -6.96985694631175 0.26157849433209657 0.9077668043896759 2.0440867648228127 0.9999812456160531 0.0011291230989437342 0.0763491349223256 0.009196011267025588 0.0069207431194532034 0.03152529848513829 1.0718723146431971e-07 6.96985694631175 1.1363199604331369 GFGFITFTNPEHASVAMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGFITFTNPEHASVAMR 18 0 P98179 P98179 RBM3 RNA-binding protein 3 0 23768000.0 12331000.0 5984500.0 5452500.0 False True 10253772.855923159 5952260.310669757 6592592.540488439 1.0 0.5804946524860257 0.6429431032968693 23.28965150848099 -10.50794248294115 6.205014027500137 1.0003434966297957 0.6117188778914859 0.980968753006815 0.025494473285643585 0.00012125136817786276 9.615215908159758e-06 0.024706157843944927 0.008228305871302282 3.10497077677775e-11 10.50794248294115 -0.3886246187383098 GFGFITFTNPEHASVAMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GFGFITFTNPEHASVAMR 18 0 P98179 P98179 RBM3 RNA-binding protein 3 0 76174400.0 19279400.0 35257000.0 21638000.0 False True 24957563.353789665 33294916.956606194 17700106.024628922 1.0 1.3340612015936464 0.7092080975100985 24.57297375269846 -6.761475980888834 1.6069244623904917 1.1936844534603124 0.7067577539673889 0.6969669917302446 0.1405381018455331 0.2804414910192615 1.4275700246975116 0.06899423799683183 0.16556260644501972 1.7319048129109563e-07 6.761475980888834 -0.48692669949292344 GFGFVCFSSPEEATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGFVCFSSPEEATK 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;Q4VXU2;H0YB86;A0A6I8PS38;A0A6I8PLA1;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC1L;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 4 0 129219000.0 34158000.0 44954000.0 50107000.0 False True 44781468.7865425 38247038.42931955 44922408.30028347 1.0 0.854081821470165 1.003147273136859 25.41639851210526 -11.027284966476204 9.106227565730821 1.1264948463464908 0.9286145473035022 0.23417218321782451 0.060855715810151395 0.05512755210904833 0.0001651786077587504 0.02078461090979448 0.019641097821187316 9.39106904383073e-12 11.027284966476204 -0.19788029904298854 GFGFVCFSSPEEATK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGFVCFSSPEEATK 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;Q4VXU2;H0YB86;A0A6I8PS38;A0A6I8PLA1;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC1L;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 4 0 74551000.0 33585000.0 13055000.0 27911000.0 False True 32518862.558499586 18267929.580925602 20600271.78794817 1.0 0.5617641006988677 0.6334868493905483 24.95477346006511 -10.698385535210795 6.776918691899732 1.0036359154196715 0.597625475044726 0.9767251679894183 0.029280689540747876 0.0016178540590896654 7.200435155407528e-05 0.02851524315574426 0.00945030191306552 2.0026933917533032e-11 10.698385535210795 -0.4060104403749455 GFGFVCFSSPEEATK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFGFVCFSSPEEATK 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;Q4VXU2;H0YB86;A0A6I8PS38;A0A6I8PLA1;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC1L;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 4 0 114721000.0 18378000.0 65893000.0 30450000.0 False True 27880769.61176963 54133879.32564119 24431544.153290898 1.0 1.9416206969691767 0.8762865765002888 24.732767049655997 -6.673476246919538 1.9259437687492689 1.5992535348038002 0.8806029464313941 0.2942185160228944 0.3996665540701698 0.45314032074439003 3.2439442597093318 0.16690302421175557 0.4437668235914533 2.1209173902898406e-07 6.673476246919538 -0.718650588372406 GFGFVCFSSPEEATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGFVCFSSPEEATK 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;Q4VXU2;H0YB86;A0A6I8PS38;A0A6I8PLA1;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC1L;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 4 0 115935000.0 34158000.0 34639000.0 47138000.0 False True 46787135.68524121 33108534.444144957 36004975.23758362 1.0 0.7076418327225981 0.7695486101095356 25.479608573628152 -10.80472626399346 7.132551530890727 1.0105806789725837 0.7385952214160668 0.959633951289501 0.02527333603634417 0.004294989992834607 0.00011758735971432488 0.024716529110939526 0.00815693413098873 1.5677389052934344e-11 10.80472626399346 -0.27198545755651693 GFGFVCFSSPEEATK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGFVCFSSPEEATK 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;Q4VXU2;H0YB86;A0A6I8PS38;A0A6I8PLA1;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC1L;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 4 0 62855500.0 33585000.0 9744500.0 19526000.0 False True 27927415.56777067 9692004.444368185 23608796.32197657 1.0 0.3470426549441667 0.8453627319966565 24.735178735499385 -9.982420731476529 6.786632427085018 1.0000000501449202 0.5962026934705339 0.4668046393312728 0.20343831956050523 1.5422267978615027e-07 2.3138653148633346e-08 0.1969783308586878 0.06565943530318744 1.0413081524676741e-10 9.982420731476529 -0.4037973566743863 GFGFVCFSSPEEATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGFVCFSSPEEATK 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;Q4VXU2;H0YB86;A0A6I8PS38;A0A6I8PLA1;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC1L;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 4 0 84310000.0 18378000.0 39169000.0 26763000.0 False True 23790683.284539282 36989210.71768178 21892408.61156962 1.0 1.554777148486515 0.9202093252107945 24.503893371748447 -6.67572233472637 1.9172499183614455 1.3523610586210026 0.9227099876559164 0.3045450550234321 0.2353523132218732 0.4481223837819702 3.180953236556743 0.09863972273696017 0.26157441517270946 2.1099767280141567e-07 6.67572233472637 -0.42965107096508626 GFGFVCFSSPEEATK(ub)AVTEMNGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 GFGFVCFSSPEEATKAVTEMNGR 23 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;Q4VXU2;H0YB86;A0A6I8PS38;A0A6I8PLA1;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC1L;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 4 1 19211700.0 5255000.0 9876800.0 4079900.0 True False 6889355.889492391 8403219.939464867 3657751.0851642783 1.0 1.2197395626318874 0.5309278753828149 22.7159376758425 -6.820894176646013 1.368092576608738 1.1183302035961709 0.5156103018640931 0.8864127566804647 0.09682162347159373 0.19231880577788693 0.7070690679824325 0.05561186495091731 0.12814104283854919 1.5104481561171357e-07 6.820894176646013 -0.6027199017320778 GFGFVCFSSPEEATK(ub)AVTEMNGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 GFGFVCFSSPEEATKAVTEMNGR 23 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;Q4VXU2;H0YB86;A0A6I8PS38;A0A6I8PLA1;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC1L;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 4 1 56440400.0 30142700.0 16008200.0 10289500.0 True False 29185836.487779792 22400357.741660163 7594371.271616669 1.0 0.7675078201386919 0.2602074220074678 24.798765081737074 -6.972803003519907 0.4628187546325269 1.0144106548445988 1.1484687427370741e-11 0.9997040824804893 0.005313545442322682 0.0781042075415737 0.023451106311018266 0.006839403459738519 0.0406933945353139 1.0646258242225246e-07 6.972803003519907 -1.0144106548331142 down GFGFVCFSSPEEATK(ub)AVTEMNGR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GFGFVCFSSPEEATKAVTEMNGR 23 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;Q4VXU2;H0YB86;A0A6I8PS38;A0A6I8PLA1;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC1L;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 4 1 214720400.0 54693600.0 85095000.0 74931800.0 True False 82974189.83775629 69909132.39973043 60121496.88622532 1.0 0.8425407049641263 0.7245807039970379 26.30615930207031 -6.974308063035782 0.11572286126945105 1.226653947063241 0.3374455231530796 0.9999995244601119 7.758840641017068e-05 0.07492788742139474 0.003434820039299285 0.008738347953951653 0.01743117807212032 1.0609427196757194e-07 6.974308063035782 -0.8892084239101614 GFGFVCFSSPEEATK(ub)AVTEMNGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GFGFVCFSSPEEATKAVTEMNGR 23 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;Q4VXU2;H0YB86;A0A6I8PS38;A0A6I8PLA1;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC1L;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 4 1 23854000.0 5255000.0 9079400.0 9519600.0 True False 7197915.511035273 8678242.086439269 7271266.542316213 1.0 1.205660454493315 1.0101905935362099 22.779147737365392 -11.035626873333541 2.8916450790252695 0.8631822073704614 1.107925523915792 0.2889996261826543 0.07980023673968796 30346804.333246756 310241.3284242637 27641544.934664972 0.02731774424853185 9.212407212450945e-12 11.035626873333541 0.24474331654533055 GFGFVCFSSPEEATK(ub)AVTEMNGR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GFGFVCFSSPEEATKAVTEMNGR 23 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;Q4VXU2;H0YB86;A0A6I8PS38;A0A6I8PLA1;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC1L;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 4 1 53302100.0 30142700.0 11961700.0 11197700.0 True False 25064990.59802412 11897259.947888447 13539087.297684977 1.0 0.47465646960291746 0.5401592809195894 24.57917035717135 -10.365584641757113 5.826650404493619 1.0000990765694442 0.5074078752617578 0.9869116615908237 0.026741410740611614 3.442409514968927e-05 3.7481385909914213e-06 0.025897421378549133 0.008630753204372931 4.309385621144427e-11 10.365584641757113 -0.4926912013076864 GFGFVCFSSPEEATK(ub)AVTEMNGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GFGFVCFSSPEEATKAVTEMNGR 23 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;Q4VXU2;H0YB86;A0A6I8PS38;A0A6I8PLA1;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC1L;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 4 1 186097800.0 54693600.0 88592200.0 42812000.0 True False 70801943.37203608 83661966.19119725 35020655.288215786 1.0 1.181633754762731 0.4946284469085284 26.07728562416276 -6.836406594004318 1.2989717371683536 1.0967128932246828 0.47359150619833473 0.9181025520738235 0.08318130074631826 0.17303439321191447 0.5686905963930462 0.05024072439825136 0.11565770920798846 1.4574491322651857e-07 6.836406594004318 -0.6231213870263481 down GFGFVDFLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGFVDFLTK 10 0 Q9Y4C8;H0YIL2 Q9Y4C8 RBM19 Probable RNA-binding protein 19 0 3802210.0 989110.0 1293800.0 1519300.0 False True 1296732.7885548656 1100770.083192899 1362097.410154684 1.0 0.8488796557844767 1.0504071634316146 20.30644979036053 -6.706041649729341 1.8095472837991513 0.9067210198728836 1.049876364119079 0.44622485613575147 0.063722048214174 0.3830639802850578 2.4425960602645436 0.02805145527247667 0.07160183647634707 1.9676975744347813e-07 6.706041649729341 0.14315534424619536 GFGFVDFLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGFVDFLTK 10 0 Q9Y4C8;H0YIL2 Q9Y4C8 RBM19 Probable RNA-binding protein 19 0 3604030.0 1218900.0 649030.0 1736100.0 False True 1180206.686692127 908191.0636467367 1281363.3281163974 1.0 0.7695186562552079 1.0857109543310515 20.170608106668872 -6.711324866931047 1.7912003415801323 0.8584909924365033 1.084974099003318 0.47108112335845576 0.09710401034608938 0.3724104421779597 2.330106609486428 0.043134839286762566 0.10937765827281822 1.9439054307523825e-07 6.711324866931047 0.2264831065668148 GFGFVDFLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGFVDFLTK 10 0 Q9Y4C8;H0YIL2 Q9Y4C8 RBM19 Probable RNA-binding protein 19 0 5343610.0 989110.0 1769000.0 2585500.0 False True 1354810.6966926923 1690839.7306992824 1974858.1500439649 1.0 1.248026558121286 1.4576635354776182 20.369659851883423 -6.973071139626669 0.16946087059664566 0.8134312635439312 1.8978700490332945 0.999997496625036 0.00029591003057126696 0.07531822562666954 0.005282846827132431 0.008878589779553069 0.024332238567410167 1.0639687205063229e-07 6.973071139626669 1.0844387854893633 GFGFVDFLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGFVDFLTK 10 0 Q9Y4C8;H0YIL2 Q9Y4C8 RBM19 Probable RNA-binding protein 19 0 2572780.0 1218900.0 754860.0 599020.0 False True 1013569.3564256548 750793.419352022 724272.312444453 1.0 0.7407420267713003 0.714575976328442 19.95101338210315 -13.999999999999998 0.32414074051032843 3.7246893711551734 0.7096179353371935 0.9997025520119942 0.0022218207079231804 18.340708277071872 0.18176321840985904 33.96377875581587 0.00857312065159754 1.0000000000000041e-14 13.999999999999998 -3.0150714358179798 GFGFVDFNSEEDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGFVDFNSEEDAK 14 0 P19338;H7BY16 P19338 NCL Nucleolin 0 76896000.0 15007000.0 30264000.0 31625000.0 False True 19674322.327994734 25748729.168148063 28352748.36842086 1.0 1.3087479578145373 1.4411041913284877 24.22981060790471 -12.48628252816736 0.1324894937115701 1.111962353842784e-18 1.6361587864939038 0.9996724117140667 0.00334507441568806 6.809059778613874 0.09852620510674567 1.9865917459461009 0.15676239620450486 3.263754411356753e-13 12.48628252816736 1.6361587864939038 GFGFVDFNSEEDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGFVDFNSEEDAK 14 0 P19338;H7BY16 P19338 NCL Nucleolin 0 75842000.0 24265000.0 12579000.0 38998000.0 False True 23494720.85698949 17601860.298618432 28783253.885077633 1.0 0.749183631751131 1.225094524862799 24.485833291255553 -6.7635322646785605 1.5993472699070188 0.8549499863421955 1.2271320003205306 0.7051337520139536 0.10555380374338254 0.27703449969626287 1.397407998466327 0.05205576578180369 0.12465715597487599 1.723724027075141e-07 6.7635322646785605 0.37218201397833506 GFGFVDFNSEEDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFGFVDFNSEEDAK 14 0 P19338;H7BY16 P19338 NCL Nucleolin 0 117022600.0 5947100.0 102700000.0 8375500.0 False True 9022185.491247961 84372382.60123758 6720078.753887935 1.0 9.351656833378525 0.7448393474515457 23.105045516715137 -6.6531127228227795 1.9978334572891994 6.406388026524389 0.7815487009089581 0.20643799016803965 3.5619546723579956 0.5010844863281781 3.8371691862545294 1.444328137109635 3.9450378790166147 2.2227328968012967e-07 6.6531127228227795 -5.62483932561543 GFGFVDFNSEEDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGFVDFNSEEDAK 14 0 P19338;H7BY16 P19338 NCL Nucleolin 0 71214000.0 15007000.0 25985000.0 30222000.0 False True 20555493.448926043 24836896.779096022 23084186.041627824 1.0 1.2082851156459915 1.1230178491693614 24.2930206694276 -10.296992746440191 4.927341281726134 0.9999430874367742 1.1656514824076505 0.8342251697651406 0.03481021577193621 2.177254119189449e-05 3.106394662283826e-06 0.033716413006326294 0.011234948830169856 5.0466972645596746e-11 10.296992746440191 0.1657083949708763 GFGFVDFNSEEDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGFVDFNSEEDAK 14 0 P19338;H7BY16 P19338 NCL Nucleolin 0 46192000.0 24265000.0 11137000.0 10790000.0 False True 20177422.62176433 11077002.770478588 13046139.11267678 1.0 0.5489800644077507 0.646571138308051 24.26623856668983 -10.47227693606727 7.060694441257907 1.0000755748174848 0.5977756013579184 0.9577155036207043 0.039841389084330124 4.7406918190751e-05 3.543271873093134e-06 0.038583448314299974 0.01285875303444837 3.3707229960476796e-11 10.47227693606727 -0.40229997345956636 GFGFVDFNSEEDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGFVDFNSEEDAK 14 0 P19338;H7BY16 P19338 NCL Nucleolin 0 24553800.0 5947100.0 11580000.0 7026700.0 False True 7698638.184866877 10935562.820361886 5747912.700030498 1.0 1.4204541839435698 0.746614214359249 22.876171838807586 -6.737967779593869 1.694016443439512 1.2507520424866794 0.7463815920699608 0.5958513051448595 0.1766673232306385 0.32149793043199154 1.8107096314620585 0.08252786680188871 0.2029789107150015 1.8282358483437086e-07 6.737967779593869 -0.5043704504167186 GFGFVDFNSEEDAK(ub)AAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGFVDFNSEEDAKAAK 17 1 P19338;H7BY16 P19338 NCL Nucleolin 1 5311300.0 1776000.0 2386300.0 1149000.0 True False 1476822.69014026 2373444.5282565374 1389250.5876242477 1.0 1.607128969579362 0.9407023584478545 20.494065193388373 -6.667014473372063 1.948746442468563 1.388531855502303 0.9434724355835314 0.2656259237530878 0.25807623048568457 0.4679627230727962 3.423466031854923 0.1067451340755148 0.28622892525697075 2.1527099919481386e-07 6.667014473372063 -0.4450594199187715 GFGFVLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGFVLFK 8 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RBQ9;A0A087WUK2;O14979-3;O14979-2;O14979;D6RF44 Q14103-3;Q14103-4;A0A087WUK2;D6RF44 HNRNPD;HNRNPDL Heterogeneous nuclear ribonucleoprotein D0;Heterogeneous nuclear ribonucleoprotein D-like 0 2348920000.0 704062100.0 838737900.0 806120000.0 False True 923032231.2470758 713601474.6947277 722710435.2490585 1.0 0.773105695053147 0.7829742134493292 29.78180578513728 -9.972721156464443 5.5840237587251895 1.000000407310234 0.7780399542530858 0.9985196205177611 0.004028805765526513 2.0429513656902375e-08 3.763091014220006e-09 0.003900881587020143 0.0013002914694554167 1.0648264823102817e-10 9.972721156464443 -0.22196045305714818 GFGFVLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGFVLFK 8 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RBQ9;A0A087WUK2;O14979-3;O14979-2;O14979;D6RF44 Q14103-3;Q14103-4;A0A087WUK2;D6RF44 HNRNPD;HNRNPDL Heterogeneous nuclear ribonucleoprotein D0;Heterogeneous nuclear ribonucleoprotein D-like 0 2905791000.0 1244935730.0 716537000.0 944318270.0 False True 1205415926.6945167 1002653960.7910922 696972986.1461442 1.0 0.8317908686842749 0.5782012421698947 30.166883885788888 -6.965173386578184 0.3550663129425611 1.0231211150653876 0.3782469823386418 0.9999166714242216 0.00158259385946136 0.07790218291726676 0.014652907622421309 0.0034386332002545937 0.021725448164441816 1.0834942562844948e-07 6.965173386578184 -0.6448741327267458 GFGFVLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFGFVLFK 8 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RBQ9;A0A087WUK2;O14979-3;O14979-2;O14979;D6RF44 Q14103-3;Q14103-4;A0A087WUK2;D6RF44 HNRNPD;HNRNPDL Heterogeneous nuclear ribonucleoprotein D0;Heterogeneous nuclear ribonucleoprotein D-like 0 2301508800.0 986550000.0 552848800.0 762110000.0 False True 1496668476.4659545 454188612.2126101 611478624.4553214 1.0 0.30346641180355066 0.40855983410513896 30.47910754276619 -10.415841009579802 6.896353947541571 1.0000602985621838 0.3560131229620726 0.9804174458387593 0.04290420999362024 3.9780618686545336e-05 3.3697050222903586e-06 0.04154567379426944 0.013847274232289737 3.838477421987073e-11 10.415841009579802 -0.6440471756001112 GFGFVLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGFVLFK 8 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RBQ9;A0A087WUK2;O14979-3;O14979-2;O14979;D6RF44 Q14103-3;Q14103-4;A0A087WUK2;D6RF44 HNRNPD;HNRNPDL Heterogeneous nuclear ribonucleoprotein D0;Heterogeneous nuclear ribonucleoprotein D-like 0 2908114100.0 704062100.0 846602000.0 1357450000.0 False True 964372884.9328393 809196324.3015667 1036848267.5603094 1.0 0.8390907054151784 1.0751528623002682 29.84501584666017 -6.723183825134989 1.7478192826790284 0.9024387804233851 1.0748532612124888 0.5274994220211716 0.06768621064359845 0.34917655817874554 2.0863052443039463 0.030728735570192983 0.07685441960566397 1.8915428101473357e-07 6.723183825134989 0.1724144807891037 GFGFVLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGFVLFK 8 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RBQ9;A0A087WUK2;O14979-3;O14979-2;O14979;D6RF44 Q14103-3;Q14103-4;A0A087WUK2;D6RF44 HNRNPD;HNRNPDL Heterogeneous nuclear ribonucleoprotein D0;Heterogeneous nuclear ribonucleoprotein D-like 0 2342244730.0 1244935730.0 518003000.0 579306000.0 False True 1035219219.4990603 515212415.02345455 700436206.191691 1.0 0.4976843602969083 0.67660664813645 29.947289161223164 -10.079231308861699 5.717996368975796 1.000002243081145 0.5871455042166176 0.8765296382006827 0.07304471813659372 2.0887731464335174e-06 3.36278637462075e-07 0.07072562829808837 0.023575081405921836 8.33237277295316e-11 10.079231308861699 -0.41285673886452745 GFGFVLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGFVLFK 8 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RBQ9;A0A087WUK2;O14979-3;O14979-2;O14979;D6RF44 Q14103-3;Q14103-4;A0A087WUK2;D6RF44 HNRNPD;HNRNPDL Heterogeneous nuclear ribonucleoprotein D0;Heterogeneous nuclear ribonucleoprotein D-like 0 2822500000.0 986550000.0 1125200000.0 710750000.0 False True 1277108422.8078253 1062581630.8697072 581400792.9108514 1.0 0.8320214727998867 0.45524779457064035 30.25023386485864 -6.957742156735495 0.4661674763023993 1.0103313812429344 0.2615913487114298 0.999677068860932 0.004093164859268461 0.08051777167934199 0.024187911646843946 0.0051727758474281495 0.0311065680981995 1.1021934942792133e-07 6.957742156735495 -0.7487400325315046 down GFGFVLFK(ub)DAASVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGFVLFKDAASVDK 15 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 1 5314700.0 2027200.0 1520100.0 1767400.0 True False 1962847.6456331762 2127083.857216776 1304464.9191365254 1.0 1.083672419481452 0.6645777740511951 20.904516765857437 -6.854799983701435 1.2116676886043878 1.0449093916429932 0.6462037905498562 0.9470011650491638 0.041690096761176146 0.1522626347003635 0.42776113574835833 0.02688592696600541 0.06243902475416784 1.397011612969439e-07 6.854799983701435 -0.398705601093137 GFGFVQFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGFVQFK 8 0 Q9NW13;C9JE21 Q9NW13 RBM28 RNA-binding protein 28 0 7818600.0 2444600.0 1730700.0 3643300.0 False True 3204894.2735400745 1472486.3062157624 3266326.2650013515 1.0 0.4594492612042636 1.0191681803572947 21.611845333795234 -10.92852435208699 12.331019646512221 1.0342577538408888 0.7393087207807814 0.22434659095129428 0.22850429188450613 0.12520513951810447 0.0007257390378590916 0.1287205303911991 0.07374944308380088 1.1788964174234134e-11 10.92852435208699 -0.29494903306010745 GFGFVQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGFVQFK 8 0 Q9NW13;C9JE21 Q9NW13 RBM28 RNA-binding protein 28 0 5910500.0 2444600.0 1406100.0 2059800.0 False True 3348434.682830984 1343973.8526491015 1573317.6629126153 1.0 0.40137377012019804 0.4698666128922158 21.675055395318125 -10.343375512697097 5.776501370854256 1.000090903209454 0.4356201915080214 0.9890745892347595 0.02796208597069312 3.2740448221666605e-05 3.721692875564693e-06 0.027078493912559513 0.009024724440808563 4.5354928569816366e-11 10.343375512697097 -0.5644707117014327 GFGFVSFER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGFVSFER 9 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 133707000.0 46570000.0 35705000.0 51432000.0 False True 61053720.98452145 30377953.17699992 46110310.010580935 1.0 0.49756104439074966 0.7552416014458968 25.863575888700648 -10.053519997602065 4.967743449821843 1.000005711651475 0.6264013229180461 0.7370331837017232 0.10519764691776896 8.647813378403991e-06 1.6476312486130598e-06 0.10185920612148734 0.033952394545657884 8.840564608399824e-11 10.053519997602065 -0.3736043887334288 GFGFVSFER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGFVSFER 9 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 98639000.0 37137000.0 12963000.0 48539000.0 False True 35958106.26276608 18139193.501151975 35825179.761212975 1.0 0.5044535262396385 0.996303295268618 25.0998137073871 -10.909384271455291 11.009965722648882 1.025096090894232 0.7503784107600356 0.2556366256633147 0.20079682737112678 0.09694836391007745 0.0007979163435476121 0.1523814223797417 0.06480689736497167 1.2320142427741918e-11 10.909384271455291 -0.2747176801341963 GFGFVSFER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFGFVSFER 9 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 59374000.0 16150000.0 21810000.0 21414000.0 False True 24500730.72315157 17917835.097692233 17181513.513910383 1.0 0.7313183961799582 0.701265350329939 24.546321441804533 -13.999999999999998 0.30925744929353693 3.585914745103029 0.6945567691321753 0.99967036131957 0.0024383901971754404 17.21721529204425 0.17691756847052983 28.637921670839443 0.01044633154277079 1.0000000000000041e-14 13.999999999999998 -2.8913579759708536 GFGFVSFER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGFVSFER 9 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 130986000.0 46570000.0 37984000.0 46432000.0 False True 63788187.50692906 36305741.283709176 35465717.89705727 1.0 0.5691608854659089 0.5559919364883157 25.92678595022354 GFGFVSFER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGFVSFER 9 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 77953000.0 37137000.0 21482000.0 19334000.0 False True 30881060.948051184 21366272.20215686 23376650.009684265 1.0 0.6918891885903689 0.7569898601932424 24.880218982821376 -10.825545704913356 7.230564281897353 1.0150943331368325 0.7244395243918056 0.9598219328566475 0.02657723788992249 0.006416704553521 0.00015481780898632765 0.025533462318805985 0.008577766644655213 1.4943567688032157e-11 10.825545704913356 -0.2906548087450269 GFGFVSFER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGFVSFER 9 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 71841000.0 16150000.0 34798000.0 20893000.0 False True 20906493.36409345 32861460.710099556 17090688.380283408 1.0 1.571830346572542 0.8174823047865301 24.317447763896983 -6.704038959308112 1.8167541711657282 1.3536838582222577 0.8195733750249857 0.4365712129236107 0.24120506486679757 0.3872127348727119 2.4874438682058124 0.105814829792737 0.2707502161647883 1.976792299809447e-07 6.704038959308112 -0.534110483197272 GFGFVSYEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGFVSYEK 9 0 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 33469400.0 6680400.0 8346000.0 18443000.0 False True 8758069.09308563 7100809.332453204 16534695.27774821 1.0 0.81077338588927 1.8879384373436967 23.062181400692587 -6.8615410695026195 1.177822927264212 0.8968726116941825 1.9416816282131122 0.9554925045721572 0.09906579092456438 0.14522836887158688 0.3819447378655309 0.06555554514134132 0.1533119400549718 1.3754947290565133e-07 6.8615410695026195 1.0448090165189297 GFGFVSYEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGFVSYEK 9 0 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 16428000.0 5191100.0 2336200.0 8900700.0 False True 5026311.371964477 3269056.843122054 6569339.654723596 1.0 0.6503888440648634 1.306990189936451 22.261068615965478 -6.76205338440439 1.6046533961388656 0.7974429288922866 1.30964173227269 0.6993016376865552 0.1470945032424222 0.2794948732333199 1.4188388762838275 0.0723091064777064 0.17342575871674556 1.7296037395653351e-07 6.76205338440439 0.5121988033804035 GFGFVSYEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGFVSYEK 9 0 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 20997900.0 6680400.0 6939700.0 7377800.0 False True 9150324.411021894 6633081.107480943 5635315.59056058 1.0 0.7249011957970757 0.6158596501532383 23.12539146221548 -13.999999999999998 0.12775469056806485 2.307216442369442 0.4587089149066995 0.9996558954812651 0.0029983347843388942 11.940774750253448 0.11092360179144864 3.927848216718496 0.13965319927214534 1.0000000000000041e-14 13.999999999999998 -1.8485075274627425 GFGFVSYEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGFVSYEK 9 0 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 11054400.0 5191100.0 3749400.0 2113900.0 False True 4316629.654722469 3729201.23800237 2555906.716430721 1.0 0.863915030079673 0.5921070188716593 22.041473891399754 -6.960070844360394 0.4344341685150646 1.0103023572300172 0.435219621325266 0.999772816878458 0.002555801739293524 0.07967582207168526 0.02103787123010003 0.003560439384263448 0.02254621923761988 1.0962993475407996e-07 6.960070844360394 -0.5750827359047512 GFGFVSYEK(ub)HEDANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGFVSYEKHEDANK 15 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 17136700.0 4137500.0 6408100.0 6591100.0 True False 5424302.567606997 5452036.4585781535 5909116.198295626 1.0 1.0051128952755657 1.08937805821966 22.371006223574902 -6.919318739878991 0.8297789263654611 0.9980946861824777 1.102755232101835 0.9939892375508759 0.0031772377659027855 0.09857418369451207 0.10770860833520306 0.0027276832792568254 0.00811806300632478 1.2041518579981466e-07 6.919318739878991 0.10466054591935736 GFGFVSYEK(ub)HEDANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGFVSYEKHEDANK 15 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 17228100.0 5397500.0 5322900.0 6507700.0 True False 5226159.316942122 7448361.728556796 4803138.143184775 1.0 1.4252075524010062 0.9190569693530006 22.317319674513858 -6.683940423820917 1.8880975783418692 1.2680830995088352 0.9209312666007027 0.34211868453465843 0.18006102785393366 0.4298489656668764 2.96603591530755 0.07643250876010858 0.20055818780477977 2.0704253486493926e-07 6.683940423820917 -0.34715183290813256 GFGFVSYEK(ub)HEDANK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFGFVSYEKHEDANK 15 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 54134300.0 9604300.0 20378000.0 24152000.0 True False 14570425.26838171 16741386.685959298 19378346.61380237 1.0 1.148997807379627 1.3299781068061207 23.79653965030522 -6.968526434181604 0.291242498685998 0.9651590900439696 1.5194180587688595 0.9999684954131733 0.0007572907965069254 0.07678381412504558 0.010732929328876874 0.003140870585642372 0.01638864644942778 1.075161156618007e-07 6.968526434181604 0.5542589687248899 GFGFVSYEK(ub)HEDANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGFVSYEKHEDANK 15 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 16058400.0 4137500.0 6382400.0 5538500.0 True False 5667245.561733291 6100404.464225605 4230420.368988009 1.0 1.0764319981856998 0.7464685133026355 22.434216285097794 -6.845719608434645 1.2555070848485181 1.0406841048569329 0.7343234697247705 0.9338501845369803 0.036271430246476055 0.16222938028527467 0.49424488462227434 0.022628628381125154 0.052242404295005936 1.4265282993135949e-07 6.845719608434645 -0.3063606351321624 GFGFVSYEK(ub)HEDANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGFVSYEKHEDANK 15 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 15927100.0 5397500.0 6748800.0 3780800.0 True False 4488260.39979282 6712442.874868083 4571347.799555923 1.0 1.4955555776527432 1.0185121611408594 22.097724949948134 -10.477518254045076 4.439394868493028 0.9987683493719735 1.257033869397103 0.27906239195334037 0.19475215926907471 0.0023850754618304137 0.00028070418797027774 0.18944133780194058 0.06285598912377358 3.330287643187004e-11 10.477518254045076 0.2582655200251296 GFGFVSYEK(ub)HEDANK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGFVSYEKHEDANK 15 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 46779300.0 9604300.0 17246000.0 19929000.0 True False 12432955.679056516 16286244.939547589 16302126.488808086 1.0 1.3099254400932188 1.311202815294294 23.56766597239767 GFGFVTFADPASVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGFVTFADPASVDK 15 0 Q96DH6;B4DHE8;Q96DH6-2;J3QKT5;J3KTC1 Q96DH6 MSI2 RNA-binding protein Musashi homolog 2 0 10051600.0 2829800.0 3066500.0 4155300.0 False True 3709895.20382218 2608990.1531233774 3725349.4164521517 1.0 0.7032517119177444 1.0041656736325193 21.8229470038626 -10.996725473912981 10.204826299623532 1.1354573489944686 0.8537086927329526 0.2396194636199902 0.1228476104467652 0.06634312945941775 2.1288185268917375e-05 0.020843567718884515 0.03964889578180816 1.0075683713865762e-11 10.996725473912981 -0.281748656261516 GFGFVTFADPASVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGFVTFADPASVDK 15 0 Q96DH6;B4DHE8;Q96DH6-2;J3QKT5;J3KTC1 Q96DH6 MSI2 RNA-binding protein Musashi homolog 2 0 9231900.0 3596100.0 1248300.0 4387500.0 False True 3481943.773905622 1746752.6997985034 3238282.1278213826 1.0 0.501660225787968 0.9300213725706061 21.731461476000018 -10.17549207193569 7.775008863481092 1.0000001104092027 0.7158407991792874 0.3697750630797365 0.17487770587515192 3.3462471241100157e-07 3.553479121530027e-08 0.16932467748174068 0.056441536873118536 6.675870876838613e-11 10.17549207193569 -0.2841593112299152 GFGFVTFADPASVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGFVTFADPASVDK 15 0 Q96DH6;B4DHE8;Q96DH6-2;J3QKT5;J3KTC1 Q96DH6 MSI2 RNA-binding protein Musashi homolog 2 0 11202300.0 2829800.0 3110100.0 5262400.0 False True 3876053.5324695725 2972685.4982746406 4019529.50253002 1.0 0.7669361306216625 1.0370159929058136 21.88615706538549 -6.67840808639082 1.9074145484024205 0.8523259962568986 1.0359778079996593 0.31684251915222483 0.09881293755291293 0.44210959838013114 3.1084391071941413 0.04158834913780723 0.10991587509772 2.096968533459638e-07 6.67840808639082 0.18365181174276068 GFGFVTFDDHDPVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGFVTFDDHDPVDK 15 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 538344000.0 122770000.0 196056000.0 219518000.0 False True 160952658.9063714 166805209.0203024 196804383.12534457 1.0 1.0363619349546471 1.2227470143244334 27.262061169150595 -6.939252095517209 0.6664832097819993 0.9978784870742837 1.2719225668308078 0.9980643163540399 0.004292692195588528 0.08810942807512372 0.056175489944229814 0.004155313388900703 0.01609536648443839 1.1501325760965083e-07 6.939252095517209 0.2740440797565241 GFGFVTFDDHDPVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGFVTFDDHDPVDK 15 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 455584200.0 123820000.0 66523200.0 265241000.0 False True 119889401.8756414 93086260.67390503 195766425.04056334 1.0 0.7764344405559828 1.6328918317869954 26.837128890434517 -6.83736628083452 1.2946148691486363 0.8809996685128335 1.6596164441085957 0.919823127837162 0.10270435302290801 0.1718975550042034 0.560788837924869 0.06223320833993753 0.14328453592184673 1.4542320743849347e-07 6.83736628083452 0.7786167755957621 GFGFVTFDDHDPVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFGFVTFDDHDPVDK 15 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 524790000.0 48942000.0 414142000.0 61706000.0 False True 74248592.13947278 340235124.39378494 49509782.053299375 1.0 4.5823781244857535 0.6668110549530337 26.145860334802958 -6.666026649279915 1.9511816726641267 3.294394684077788 0.6828060740527648 0.26159385258227097 1.5231274821443386 0.47036440489866527 3.448330387783779 0.6292613075056577 1.6901577331266975 2.1576120091960928e-07 6.666026649279915 -2.6115886100250227 GFGFVTFDDHDPVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGFVTFDDHDPVDK 15 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 567105000.0 122770000.0 266494000.0 177841000.0 False True 168161386.73450074 254719413.90219033 135838618.5503652 1.0 1.514731882559642 0.8077872167219465 27.325271230673486 -6.711483094404417 1.7902145774173193 1.3159664930815216 0.809394366527392 0.4720552872627779 0.2168550521159645 0.3720780272907038 2.325469647024481 0.0963705577405977 0.24436007523111156 1.943197332367804e-07 6.711483094404417 -0.5065721265541295 GFGFVTFDDHDPVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGFVTFDDHDPVDK 15 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 217532000.0 123820000.0 81313000.0 12399000.0 False True 102961816.1560626 80874950.7296332 14991573.573501348 1.0 0.7854848889519235 0.14560323557985932 26.617534165868793 -7.116865257151225 0.6187971547559864 1.00212016457443 5.2506581851510546e-27 0.9984742028241235 0.014176544942532938 0.07849700511472091 0.048703989526857276 0.014129531408202473 0.04863148812699775 7.640728056478603e-08 7.116865257151225 -1.00212016457443 down GFGFVTFDDHDPVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGFVTFDDHDPVDK 15 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 216340000.0 48942000.0 104908000.0 62490000.0 False True 63356383.79105033 99069777.57845654 51117461.20154643 1.0 1.5636905336199294 0.8068241610842575 25.916986656895407 -6.707276350360015 1.8047179548322188 1.3474979110879424 0.8087251476154201 0.45226295940416383 0.2376390870747818 0.38056808709229467 2.4144410031589283 0.10485067953956907 0.26727300644806484 1.9621113483952524e-07 6.707276350360015 -0.5387727634725222 GFGFVTFDDHDPVDK(ub)IVLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGFVTFDDHDPVDKIVLQK 20 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 23948900.0 3783500.0 12906900.0 7258500.0 True False 4960205.139466123 10981240.83070215 6507460.0484484825 1.0 2.2138682820453037 1.3119336530401833 22.241968356785215 -10.251855159114603 4.983208613995007 0.9998573386432209 1.7629009675432834 0.4882157933431396 0.3682132704033697 0.0005837092027356865 8.763359254786338e-05 0.3565866537384789 0.11884032201013403 5.599443165265478e-11 10.251855159114603 0.7630436289000625 GFGFVTFDDHDPVDK(ub)IVLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGFVTFDDHDPVDKIVLQK 20 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 130702000.0 47473000.0 47107000.0 36122000.0 True False 45965995.60040645 65917070.75975969 26660564.56322827 1.0 1.434039878800685 0.5800062462476615 25.45406365320572 -6.768558690522849 1.58012657358207 1.2494129169883528 0.5754792036222682 0.724964724411288 0.18285764682903224 0.26876435501351614 1.324148400480045 0.09123103057563133 0.21744237400222513 1.703889040322214e-07 6.768558690522849 -0.6739337133660845 GFGFVTFDDHDPVDK(ub)IVLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFGFVTFDDHDPVDKIVLQK 20 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 338191000.0 79766000.0 87231000.0 171194000.0 True False 121010853.67572199 71663946.51108627 137357430.86300442 1.0 0.5922108995539132 1.1350835622653077 26.850561210250813 -6.705710242214796 1.8105448622418197 0.7482082256149021 1.1336511672457086 0.44469048663445254 0.17196001518287823 0.38376225845900125 2.449489854616736 0.0756607192619639 0.19321680801107818 1.969199685706118e-07 6.705710242214796 0.3854429416308065 GFGFVTFDDHDPVDK(ub)IVLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGFVTFDDHDPVDKIVLQK 20 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 41152800.0 3783500.0 17214900.0 20154400.0 True False 5182362.195243 16454288.79593843 15394345.81289736 1.0 3.175055732507884 2.97052680475096 22.305178418308106 -9.886121946973883 6.157695261846258 0.9999997133327355 3.0727912686299987 0.9927506380770494 0.08349858510922854 3.287766387409523e-07 5.947580981608567e-08 0.08084716702542767 0.026949052463025005 1.2998045503985101e-10 9.886121946973883 2.0727915552972633 GFGFVTFDDHDPVDK(ub)IVLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGFVTFDDHDPVDKIVLQK 20 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 113860000.0 47473000.0 46257000.0 20130000.0 True False 39475902.91048912 46007804.359704375 24339089.929396104 1.0 1.1654655363811746 0.6165556234289191 25.234468928639995 -6.825881029393779 1.3463440914656293 1.0886936272676944 0.6030021973189936 0.8973585281707293 0.07365658174085755 0.18594849554492482 0.6606486421533442 0.04297364915458869 0.0989216758113061 1.4932034016136108e-07 6.825881029393779 -0.48569142994870074 GFGFVTFDDHDPVDK(ub)IVLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGFVTFDDHDPVDKIVLQK 20 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 288920000.0 79766000.0 82063000.0 127091000.0 True False 103258659.42292754 77496121.91082545 103961742.06378202 1.0 0.7505048229748585 1.0068089460465954 26.621687532343262 -10.992131501374754 10.35007077836073 1.1005948243053871 0.8786568844857316 0.23009002002950307 0.10463572008287614 0.06658598179808113 5.062108719777657e-05 0.027774617450942934 0.03377103344161668 1.0182830122941644e-11 10.992131501374754 -0.22193793981965548 GFGFVTFENIDDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGFVTFENIDDAK 14 0 Q14011;K7ENX8;K7ELV6;K7EJV5;K7ELT6;K7EJV1;K7EMY9;K7EPM4;K7ER40;K7EQR7;D6W5Y5;Q14011-2 Q14011 CIRBP Cold-inducible RNA-binding protein 0 13646600.0 3914900.0 4957100.0 4774600.0 False True 5132471.811945528 4217520.002624459 4280570.193197226 1.0 0.8217327161560688 0.8340172825176457 22.29122236825268 -10.562125468453855 6.519193715907862 1.0002405775293568 0.8278749993368573 0.9961942730013198 0.00501515321620366 1.756046008753659e-05 1.1794856840467685e-06 0.0048626250530185156 0.0016186337404196069 2.7407822406388072e-11 10.562125468453855 -0.17236557819249954 GFGFVTFENIDDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGFVTFENIDDAK 14 0 Q14011;K7ENX8;K7ELV6;K7EJV5;K7ELT6;K7EJV1;K7EMY9;K7EPM4;K7ER40;K7EQR7;D6W5Y5;Q14011-2 Q14011 CIRBP Cold-inducible RNA-binding protein 0 21636100.0 7142800.0 4760100.0 9733200.0 False True 6916055.72377105 6660832.7535935715 7183782.930258932 1.0 0.9630970338627759 1.0387109672305967 22.721518062376706 -6.773959119726145 1.559005577623145 0.9789414645748262 1.0392046448744352 0.7456110389948797 0.015571006754260418 0.26005517173679643 1.2478561844699472 0.007869700122690766 0.01866820446041279 1.6828324591549916e-07 6.773959119726145 0.060263180299608976 GFGFVTFENIDDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGFVTFENIDDAK 14 0 Q14011;K7ENX8;K7ELV6;K7EJV5;K7ELT6;K7EJV1;K7EMY9;K7EPM4;K7ER40;K7EQR7;D6W5Y5;Q14011-2 Q14011 CIRBP Cold-inducible RNA-binding protein 0 16366300.0 3914900.0 5261900.0 7189500.0 False True 5362344.326194477 5029411.8592236 5491488.172400344 1.0 0.9379128890801476 1.0240834676682384 22.35443242977557 -6.713357498344701 1.7830566732558033 0.9619620143177219 1.0239032515215893 0.48109163313982206 0.026149893543251826 0.3683788753397706 2.284990489050866 0.011661458271115015 0.029507589801858893 1.9348286146717508e-07 6.713357498344701 0.06194123720386746 GFGFVTFENIDDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGFVTFENIDDAK 14 0 Q14011;K7ENX8;K7ELV6;K7EJV5;K7ELT6;K7EJV1;K7EMY9;K7EPM4;K7ER40;K7EQR7;D6W5Y5;Q14011-2 Q14011 CIRBP Cold-inducible RNA-binding protein 0 14747000.0 7142800.0 3597900.0 4006300.0 False True 5939554.679692488 3578517.3985727658 4843998.806961726 1.0 0.6024891749557962 0.8155491561553428 22.501923337810982 -10.053572060394483 5.033959862439837 1.0000050070753186 0.7090191655539968 0.7132148585250089 0.08698137309643773 4.887928928930274e-06 9.192007006498028e-07 0.0842208015671032 0.028073117451947745 8.839504873790417e-11 10.053572060394483 -0.2909858415213218 GFGFVTYATVEEVDAAMNAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFGFVTYATVEEVDAAMNAR 20 0 P09651;F8W6I7;P09651-3;F8VZ49;F8W646;F8VYN5;P09651-2;A0A2R8Y4L2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 106044000.0 14443000.0 58219000.0 33382000.0 False True 21911086.924735494 47829364.58287678 26784033.068149615 1.0 2.182884160296131 1.2223963676540865 24.38515771686607 -10.21458259735574 4.101024679754332 0.9996570940830453 1.702640262995442 0.4164143526620251 0.392117502277393 49728969.95011825 30966039.741164964 174676.7127788999 0.13423225036205114 6.101230078765217e-11 10.21458259735574 0.7029831689123968 GFGFVTYATVEEVDAAMNAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGFVTYATVEEVDAAMNAR 20 0 P09651;F8W6I7;P09651-3;F8VZ49;F8W646;F8VYN5;P09651-2;A0A2R8Y4L2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 42209000.0 14443000.0 13616000.0 14150000.0 False True 18696748.214092992 12858257.630574062 11574845.1912607 1.0 0.6877269503411257 0.6190833324982129 24.156284038958518 -13.999999999999975 0.21289125684458812 2.827794522516105 0.5797675934021287 0.9994918305131774 0.0037369352458451496 12.815872841603134 0.14622320124002178 9.812057302252374 0.039852658757981 1.0000000000000573e-14 13.999999999999975 -2.2480269291139763 GFGFVYFQNHDAADK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGFVYFQNHDAADK 15 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 148514400.0 46117700.0 43409200.0 58987500.0 False True 60460751.30444214 36932716.56773634 52884039.348054595 1.0 0.6108544100248857 0.8746837941487692 25.849495570673987 -9.949463633154274 5.344610292304699 1.0000006246196675 0.742769102085686 0.5589803922342975 0.10770789504670986 8.016497895865726e-07 1.5744824039833613e-07 0.10428797346141766 0.03476257364700231 1.1234050371536133e-10 9.949463633154274 -0.2572315225339815 GFGFVYFQNHDAADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGFVYFQNHDAADK 15 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 149325700.0 46204400.0 21443300.0 81678000.0 False True 44737666.61300983 30005721.515332274 60284081.51252307 1.0 0.6707037668032183 1.3475016932374453 25.414986675780057 -6.774396562573022 1.557513244692303 0.8121853229728483 1.3519668865251566 0.7471110368396339 0.13896348591050892 0.2593894310944571 1.2423593320024544 0.07030017725444479 0.1666855958080676 1.6811382805801922e-07 6.774396562573022 0.5397815635523083 GFGFVYFQNHDAADK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFGFVYFQNHDAADK 15 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 183455600.0 42071500.0 41107100.0 100277000.0 False True 63825541.33864223 33771216.83376175 80457206.99702956 1.0 0.5291175934502489 1.2605800955160553 25.927630533166102 -6.732865261923112 1.7126140238948961 0.7175335999333049 1.260390634187927 0.5725478318063245 0.19790761494329492 0.33090499186937844 1.9026476070601297 0.09152448731054626 0.22639345281540443 1.8498424359692092e-07 6.732865261923112 0.5428570342546221 GFGFVYFQNHDAADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGFVYFQNHDAADK 15 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 146976900.0 46117700.0 31317700.0 69541500.0 False True 63168659.973981276 29933980.46021528 53117229.95214945 1.0 0.47387391900579934 0.8408794800147424 25.91270563219688 -10.097542590417268 6.038107497760526 1.0000012180974753 0.6573766995102674 0.5374773916900578 0.14982939287266225 2.4568616118851167e-06 3.673265923821924e-07 0.14507220029409915 0.04835722861401133 7.988355975687034e-11 10.097542590417268 -0.3426245185872079 GFGFVYFQNHDAADK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGFVYFQNHDAADK 15 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 95049700.0 46204400.0 22886000.0 25959300.0 False True 38421005.80198006 22762708.57548466 31387269.607758135 1.0 0.5924547809290188 0.8169299307135932 25.195391951214333 -10.10503925306136 5.2089238218275815 1.0000064341670858 0.7046923558209317 0.6976616309263239 0.09164159615247894 6.847730254574717e-06 1.1763196169437066e-06 0.08873352647893512 0.029577197976346583 7.851646654614122e-11 10.10503925306136 -0.2953140783461541 GFGFVYFQNHDAADK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGFVYFQNHDAADK 15 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 240128500.0 42071500.0 120840000.0 77217000.0 False True 54462386.103248194 114115147.77310292 63164298.313327104 1.0 2.0953020228817514 1.15977838711624 25.69875685525855 -6.607690899131527 2.1617036479787326 1.7328868396946233 1.1630186533390026 0.0434057224985509 0.47249337140573 0.6190767691229325 5.478303140024588 0.1806852325306758 0.5249249614260109 2.4677951187540417e-07 6.607690899131527 -0.5698681863556208 GFGGIGGILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGGIGGILR 10 0 P62495;B7Z7P8;P62495-2 P62495 ETF1 Eukaryotic peptide chain release factor subunit 1 0 32231300.0 8868600.0 8623700.0 14739000.0 False True 11626820.48364458 7337077.574919324 13213949.666471312 1.0 0.631047635528593 1.1365058646135753 23.470953289860095 -6.711023870441653 1.7918330898494075 0.7734129037416181 1.135341409091868 0.46987906883033204 0.1554494926985554 0.3729993909726137 2.335160387043404 0.06902647974359936 0.17512408986792957 1.945253160328204e-07 6.711023870441653 0.36192850535025 GFGGIGGILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGGIGGILR 10 0 P62495;B7Z7P8;P62495-2 P62495 ETF1 Eukaryotic peptide chain release factor subunit 1 0 24976800.0 7054000.0 3694800.0 14228000.0 False True 6830074.631164385 5170152.9081274625 10501259.969149308 1.0 0.7569687283557631 1.537502960982882 22.703469912030243 -6.823067063847692 1.35864799421302 0.8693978105686243 1.5556754338453012 0.8912641197239217 0.10753954327968818 0.18953297206211062 0.6866244787136331 0.06218698171876751 0.14322041444215616 1.502909868503721e-07 6.823067063847692 0.6862776232766769 GFGGIGGILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGGIGGILR 10 0 P62495;B7Z7P8;P62495-2 P62495 ETF1 Eukaryotic peptide chain release factor subunit 1 0 30475100.0 8868600.0 7773500.0 13833000.0 False True 12147561.08490342 7430041.06647308 10565930.299577719 1.0 0.6116487922589567 0.8697984908846188 23.534163351382986 -10.12442129753548 5.217466726457284 1.0000070058361963 0.740723641571538 0.5735602285625258 0.10538917314856017 8.588666474256796e-06 1.4413708344904246e-06 0.10204538419821152 0.034014209372786375 7.50894118163358e-11 10.12442129753548 -0.25928336426465826 GFGGIGGILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGGIGGILR 10 0 P62495;B7Z7P8;P62495-2 P62495 ETF1 Eukaryotic peptide chain release factor subunit 1 0 15832600.0 7054000.0 4182900.0 4595700.0 False True 5865713.545185474 4160365.887459357 5556639.621884033 1.0 0.7092685067913261 0.9473083844070214 22.48387518746452 -9.983129045097966 6.238760237227207 1.0000000777652607 0.8282884461620948 0.40961377524217224 0.09717937309886449 1.0505461756639147e-07 1.7080301369032652e-08 0.09409356546466086 0.03136450780056056 1.0396112126421478e-10 9.983129045097966 -0.17171163160316583 GFGHIGIAVPDVYSACK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGHIGIAVPDVYSACK 17 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 193447200.0 64058200.0 68225700.0 61163300.0 False True 83980920.54049128 58046691.50169561 54834708.435801946 1.0 0.6911890358918902 0.6529424550587472 26.323558266291624 -13.999999999999998 0.29456941165236455 3.7307515351165184 0.6429917856449155 0.9996376907596246 0.0029574911520383338 16.24320242816956 0.1722207284868465 26.950715073994985 0.014153003595156068 1.0000000000000041e-14 13.999999999999998 -3.0877597494716027 GFGHIGIAVPDVYSACK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGHIGIAVPDVYSACK 17 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 115778900.0 67647900.0 21540000.0 26591000.0 False True 65500454.443088345 30141034.329616062 19626019.387099344 1.0 0.4601652703922051 0.29963180490834435 25.965001580335144 -13.999999999999998 0.16997353687001882 3.722213056151614 0.1579830264990372 0.9995137285337792 0.006606100887811934 12.091242983514045 0.13055478854683453 10.85257451333157 0.1309122788666934 1.0000000000000041e-14 13.999999999999998 -3.5642300296525766 GFGHIGIAVPDVYSACK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFGHIGIAVPDVYSACK 17 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 155956100.0 34302800.0 72363300.0 49290000.0 False True 52039855.47059593 59449503.73795658 39547809.8954255 1.0 1.14238410541988 0.7599523391791737 25.63311361950045 -6.805862390637884 1.4316366936856608 1.0779864050389654 0.7538628387469866 0.8488063378884151 0.06136419932111134 0.2124951523493835 0.8590859967129361 0.03370934747916678 0.0781407150681245 1.5636430158062924e-07 6.805862390637884 -0.3241235662919788 GFGHIGIAVPDVYSACK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGHIGIAVPDVYSACK 17 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 224996500.0 64058200.0 68596800.0 92341500.0 False True 87742247.64776403 65565966.556717075 70532339.53288913 1.0 0.7472565191163977 0.8038583626901942 26.386768327814515 -10.815270638545227 7.148934783739005 1.010727215502011 0.7755574409047551 0.9544723361653072 0.02310760587610542 0.004014838140108202 0.00010374377875992905 0.022736490889935897 0.007457947727406741 1.530133633770781e-11 10.815270638545227 -0.23516977459725596 GFGHIGIAVPDVYSACK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFGHIGIAVPDVYSACK 17 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 112537900.0 67647900.0 11908000.0 32982000.0 False True 56252226.16010099 11843849.24044705 39878383.708462045 1.0 0.21054898710564715 0.7089209873216945 25.74540685576942 -9.857298892202161 5.80162212346405 1.0000001267905196 0.45973498722838174 0.6104271476540118 0.20345951710695717 3.3353703712204713e-07 6.577757814331755e-08 0.19699887731164234 0.0656662767813474 1.3889963605425695e-10 9.857298892202161 -0.5402651395621378 GFGHIGIAVPDVYSACK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGHIGIAVPDVYSACK 17 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 152317300.0 34302800.0 69317500.0 48697000.0 False True 44405650.80927712 65459920.19002044 39834645.673415035 1.0 1.474134912945465 0.8970625347775081 25.4042399415929 -6.688360870136382 1.8719858618265564 1.2977005312585612 0.8990802228359746 0.36290396433737704 0.2005917337913661 0.4201867157023742 2.8535058199927144 0.08575844391625075 0.2238044103993491 2.0494585059465832e-07 6.688360870136382 -0.39862030842258667 GFGHIGIAVPDVYSACK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGHIGIAVPDVYSACKR 18 1 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 1 16454000.0 3113000.0 4468800.0 8872200.0 True False 4029839.866403893 4220107.351609087 7257550.636459592 1.0 1.047214651577454 1.8009526127736708 21.942291080897512 -6.9196829406058065 0.827075888961419 0.983178616001804 1.9216173010727846 0.9940924034908117 0.028204155629196592 0.09835858636204294 0.1065838153081008 0.024260079431868673 0.07245156061520572 1.2031424757343175e-07 6.9196829406058065 0.9384386850709806 GFGYK(ub)GSCFHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFGYKGSCFHR 11 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 17626100.0 5468100.0 7005100.0 5152900.0 True False 7168732.053155733 5959966.385665932 4619727.33810707 1.0 0.8313836172803121 0.6444273971815461 22.773286538685504 -6.969793676929126 0.2630695551493429 1.0505595763481135 0.4196823981757883 0.9999807262315942 0.0006375447182892972 0.07636969736764294 0.009269524492370226 0.0038267363603604896 0.017559652080836458 1.072028479739784e-07 6.969793676929126 -0.6308771781723252 GFGYK(ub)GSCFHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFGYKGSCFHR 11 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 18429400.0 6662700.0 6126000.0 5640700.0 True False 6451196.235477588 8572143.74666796 4163231.452627249 1.0 1.3287680972292353 0.645342553638665 22.621135271406555 -6.775897726433992 1.5519129739141944 1.187147572869125 0.6406132187833419 0.7525989656031793 0.13880981735771858 0.2569935847669965 1.2222334406572142 0.07047099170518567 0.16685711711078613 1.6753373607823344e-07 6.775897726433992 -0.5465343540857831 GFGYK(ub)GSCFHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFGYKGSCFHR 11 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 42814300.0 8809300.0 11567000.0 22438000.0 True False 13364352.146096533 9502778.476616498 18003119.465075225 1.0 0.7110541815071877 1.3471000515601936 23.67188656701754 -6.783177397616396 1.5232216100729268 0.8370634419135362 1.3526725238019282 0.7785295860772767 0.12236998789311065 0.24568526951742065 1.1260618209643147 0.06325806839043317 0.1488879366792205 1.6474892989919831e-07 6.783177397616396 0.5156090818883919 GFGYK(ub)GSCFHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGYKGSCFHR 11 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 16985600.0 5468100.0 5379400.0 6138100.0 True False 7489804.339846244 5141720.32070306 4688407.198137639 1.0 0.6864959466763071 0.6259719193457444 22.836496600208395 -13.999999999999996 0.2312614156748998 2.9906815236644584 0.5968955949322777 0.9995115413966619 0.0036229354093491057 13.330960401381136 0.1522581724143398 12.194152266905592 0.031172846025495485 1.0000000000000082e-14 13.999999999999996 -2.3937859287321808 GFGYK(ub)GSCFHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFGYKGSCFHR 11 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 41852300.0 8809300.0 11584000.0 21459000.0 True False 11403812.507263675 10939340.216845617 17553682.18793384 1.0 0.9592704378362752 1.5392819003954157 23.44301288910999 -6.8900484590335225 1.022070435350221 0.9688715583694162 1.5892204266185028 0.9809301759245395 0.03650412145247572 0.11910488555473348 0.22160560595236006 0.027211311547498746 0.06785175113405592 1.2881058154770682e-07 6.8900484590335225 0.6203488682490866 GFGYKGSCFHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFGYKGSCFHR 11 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 23743100.0 12402000.0 10165000.0 1176100.0 False True 16987354.551448055 9715876.688840134 898329.4025398226 1.0 0.5719476013416064 0.052882242483321 24.017957862662456 -7.718818428036054 0.5504855402225335 1.0109296793229914 3.722333872618728e-21 0.9932748955783522 0.03175742118578163 0.11589257845016052 0.11285954846213589 0.03372873484645367 0.07639398889164761 1.9106519063097075e-08 7.718818428036054 -1.0109296793229914 down GFHCESSAHWPIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFHCESSAHWPIFK 14 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 86594700.0 23046000.0 20157700.0 43391000.0 False True 30213529.17778148 17150249.734099165 38901315.555862494 1.0 0.5676347716012987 1.2875462289413666 24.84869137624518 -6.744076956895755 1.67179899917688 0.7439631851045562 1.2883513665691735 0.6230653515114624 0.181654414368887 0.3105015387499541 1.7054586039427937 0.0859072951379087 0.20987041099592527 1.8026982747802436e-07 6.744076956895755 0.5443881814646173 GFHCESSAHWPIFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFHCESSAHWPIFK 14 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 19658800.0 12893300.0 1721000.0 5044500.0 False True 12484009.248935618 2408204.2748964364 3723194.118243862 1.0 0.19290311524735204 0.2982370522163223 23.5735779954205 -10.714672353505387 6.91811547475121 1.0080110472831436 0.24557008373183717 0.9855902482416548 0.043002399695410407 0.005283653243810752 0.00021791637458686027 0.04140387387248562 0.013878964822273271 1.928979652077785e-11 10.714672353505387 -0.7624409635513064 GFHCESSAHWPIFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFHCESSAHWPIFK 14 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 58101800.0 10807800.0 23216000.0 24078000.0 False True 16396222.756017176 19072923.412564103 19318972.746237714 1.0 1.1632510546104051 1.1782575190464482 23.96686015961513 -13.132639676265555 0.34876652443502265 8.724860333581737e-12 1.1804231237925067 0.999717152024732 0.001357663654081075 11.246799653410434 0.18823316641298038 8.13421952315695 0.004497786750458708 7.368181643571447e-14 13.132639676265555 1.180423123783782 GFHCESSAHWPIFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFHCESSAHWPIFK 14 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 80259000.0 23046000.0 27964000.0 29249000.0 False True 31566728.994732432 26728458.015418116 22340988.60206383 1.0 0.846728782696437 0.707738473815006 24.911901437768073 -6.972289936965584 0.19592488823366316 1.087208206422781 0.4634383326511974 0.999995165334239 0.0002623897690503163 0.07556649282890816 0.006294762486271091 0.004667612302740894 0.014911284939030304 1.0658842944586868e-07 6.972289936965584 -0.6237698737715837 GFHCESSAHWPIFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFHCESSAHWPIFK 14 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 28588400.0 12893300.0 2466800.0 13228300.0 False True 10721350.22003685 2453510.8587785386 15994276.36925139 1.0 0.22884345799964978 1.491815493477688 23.353983270854776 -6.74148575759495 1.6815691574220077 0.5419508413985745 1.4927528307085904 0.6114741480084942 0.3239965770477009 0.31512886271392987 1.7502609446882067 0.1524005491654629 0.37332387508929665 1.8134861469942586e-07 6.74148575759495 0.9508019893100159 GFHCESSAHWPIFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFHCESSAHWPIFK 14 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 52532800.0 10807800.0 29785000.0 11940000.0 False True 13990910.15358818 28127438.566880774 9767042.514745785 1.0 2.01040806195636 0.6980991520584442 23.73798648170758 -6.70106854670506 1.8272427811564913 1.626769761271617 0.7019468307946534 0.4225823781883514 0.4264231659061703 0.39329552255899886 2.553716409476399 0.18613329678356103 0.47802267607365173 1.9903591666089957e-07 6.70106854670506 -0.9248229304769636 GFHQEVFLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFHQEVFLGK 10 0 A0A5F9UP49;Q9BRK5;A0A5F9UJX7;Q9BRK5-6;H0Y3T6;G3V1E2;Q9BRK5-4;Q9BRK5-3 A0A5F9UP49 SDF4 45 kDa calcium-binding protein 0 3321670.0 951570.0 1150500.0 1219600.0 False True 1303391.1442123381 1099667.10580527 931555.5984504437 1.0 0.8436969291131848 0.7147168389067112 20.313838667147493 -6.973327113744077 0.1598338790681592 1.1308373112773236 0.424154722696198 0.9999980702188516 0.00016193533796461703 0.07523715932970237 0.004933066404286613 0.0059793203676168655 0.015487208877352157 1.0633417997879971e-07 6.973327113744077 -0.7066825885811255 GFHQVPFAPIVFIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFHQVPFAPIVFIER 15 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQX5;A0A0U1RRC8 P47897 QARS Glutamine--tRNA ligase 0 12838500.0 5085500.0 5973900.0 1779100.0 False True 6667139.748052054 5082617.406079818 1595015.7983322574 1.0 0.7623385136879441 0.23923539307815994 22.668636536683405 -7.021720589949926 0.4802964119257417 1.0124986352863792 1.0726212733328476e-11 0.9996643998889309 0.005821615052544545 0.07408101402191476 0.024941247470737775 0.007282713360073843 0.03953634943995206 9.51216576683848e-08 7.021720589949926 -1.0124986352756529 down GFHQVPFAPIVFIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFHQVPFAPIVFIER 15 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQX5;A0A0U1RRC8 P47897 QARS Glutamine--tRNA ligase 0 13097300.0 4655600.0 4283900.0 4157800.0 False True 4507810.526346601 5994483.610243375 3068747.4486736725 1.0 1.329799372712691 0.6807622970703627 22.103995446315036 -6.768580022873063 1.579985989313323 1.1895093431350758 0.6773149721249765 0.7250533958231595 0.13894317769461306 0.2687379944694904 1.3237767615250153 0.06932631951792873 0.16523482753146623 1.7038053481120562e-07 6.768580022873063 -0.5121943710100993 GFHQVPFAPIVFIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFHQVPFAPIVFIER 15 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQX5;A0A0U1RRC8 P47897 QARS Glutamine--tRNA ligase 0 20601000.0 5085500.0 6574400.0 8941100.0 False True 6965746.780470003 6283921.269366501 6829396.327734713 1.0 0.9021173848846832 0.9804255800515778 22.731846598206296 -10.097265696220767 4.519650664074422 1.0000048843328644 0.9412714824657924 0.42854949637373685 0.03196918681415503 1.5735536121280213e-06 3.1427830331526695e-07 0.030956606399580283 0.010318010675799235 7.993450755344525e-11 10.097265696220767 -0.05873340186707199 GFHQVPFAPIVFIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFHQVPFAPIVFIER 15 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQX5;A0A0U1RRC8 P47897 QARS Glutamine--tRNA ligase 0 12822000.0 4655600.0 4369400.0 3797000.0 False True 3871337.6780501134 4345861.174942008 4590935.144655592 1.0 1.1225735227341107 1.1858782484115207 21.884400721749312 -13.999999999989088 0.08411877302704832 0.3543309138849771 1.3613167762689997 0.9998691244576997 0.0008826938671033576 12.218420063747919 0.08277775524324102 1.442067432334316 0.15856063294273157 1.0000000000251262e-14 13.999999999989088 1.0069858623840227 GFHQVPFAPIVFIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFHQVPFAPIVFIER 15 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQX5;A0A0U1RRC8 P47897 QARS Glutamine--tRNA ligase 0 8611900.0 4196700.0 0.0 4415200.0 False True 5432710.879324518 0.0 3611678.9037776897 1.0 0.0 0.6648023397532157 22.373240840323177 -10.366320167771855 7.789631996107112 1.0000077336207451 0.3324011698766079 0.5734833318448673 0.27140441870062654 3.6452045896454446e-05 2.9654743170365704e-06 0.26278923594426673 0.0875953994762193 4.3020933740904776e-11 10.366320167771855 -0.6676065637441373 GFIMAEVMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFIMAEVMK 9 0 J3KQ32;Q9NTK5;Q9NTK5-2 J3KQ32 OLA1 Obg-like ATPase 1 0 5152850.0 935050.0 2132300.0 2085500.0 False True 1225859.6050370813 1814169.1516403016 1869712.4655285925 1.0 1.4799159252705976 1.525225611355417 20.22536232917264 -11.71896011620861 0.38436912440503673 1.0164604567418324e-10 1.5294311907741736 0.9996579808467939 0.004394763712551865 4.575965753783646 0.1958425670461847 3.7489406850791016 0.012111092063603964 1.9100286595669405e-12 11.71896011620861 1.5294311906725275 GFIMAEVMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFIMAEVMK 9 0 J3KQ32;Q9NTK5;Q9NTK5-2 J3KQ32 OLA1 Obg-like ATPase 1 0 2483950.0 935050.0 1548900.0 0.0 False True 1280763.2537761244 1480464.4764726486 0.0 1.0 1.1559236042318806 0.0 20.28857239069553 -6.933578648433409 1.2335700849147986 1.0838818943123179 1.7103600863418222e-21 0.96564970677683 0.09491685810310689 0.11513898656979976 0.34964482072201314 0.06360111132705626 0.12261681609766002 1.1652560100289615e-07 6.933578648433409 -1.0838818943123179 down GFIYVHKPPVHIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFIYVHKPPVHIR 13 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 271628000.0 75767000.0 69391000.0 126470000.0 False True 99331270.72867167 59038133.28399947 113384097.58590335 1.0 0.5943559651548713 1.1414743489552013 26.56574463194694 -6.708139137444101 1.8015274222640287 0.7501365795865332 1.1401317061162644 0.45622111884623606 0.17098892975516497 0.3789230107525756 2.3960327673627697 0.07555850729227494 0.19241084731686173 1.9582172075853212e-07 6.708139137444101 0.3899951265297311 GFIYVHKPPVHIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFIYVHKPPVHIR 13 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 280524330.0 88044330.0 27660000.0 164820000.0 False True 85249410.93717955 38704782.244994506 121648697.50598739 1.0 0.454018178184435 1.4269740537636153 26.345186529539596 -6.754438719124544 1.633474493139412 0.6806802787680347 1.4295768527073138 0.6678415623862999 0.22949350320831494 0.2923562984260242 1.5360698936004522 0.11092559368043862 0.26804848019877653 1.7601970178765688e-07 6.754438719124544 0.7488965739392791 GFIYVHKPPVHIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFIYVHKPPVHIR 13 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 77480000.0 25680000.0 22771000.0 29029000.0 False True 38958437.45947565 18707337.139364943 23291405.426137336 1.0 0.48018704956594344 0.5978526590129526 25.215432479345548 -9.857003338795254 6.5942890193682935 1.000000013379254 0.5390198542894981 0.9534117471612871 0.04803678390323698 9.421923966863959e-09 1.6816348784597745e-09 0.04651141740174924 0.015503805338534326 1.3899419454929428e-10 9.857003338795254 -0.46098015908975587 GFIYVHKPPVHIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFIYVHKPPVHIR 13 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 239101500.0 75767000.0 81543000.0 81791500.0 False True 103780107.42618632 77940160.6333587 62474032.24881882 1.0 0.7510125260642431 0.6019846558094336 26.628954693469833 -11.430843356305251 0.07123313270940396 2.0729127832655685 6.748165984335072e-05 0.9999609320464709 0.0010262324803580252 4.328248710320202 0.04834850332287425 1.1483581399354383 0.40938590596871005 3.7081444503505704e-12 11.430843356305251 -2.0728453016057253 GFIYVHKPPVHIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFIYVHKPPVHIR 13 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 175062330.0 88044330.0 46851000.0 40167000.0 False True 73212761.4201558 46598604.36380461 48565733.98877558 1.0 0.6364819938478077 0.6633506651943499 26.125591804973872 -10.75771111601739 6.93310624031142 1.007317407713292 0.6499163295212926 0.9956015907043784 0.010969089144261257 0.001249563294876907 4.3668000525052674e-05 0.010696874619696236 0.003540258298232366 1.7469838251340192e-11 10.75771111601739 -0.3574010781919994 GFIYVHKPPVHIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFIYVHKPPVHIR 13 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 140814000.0 25680000.0 53145000.0 61989000.0 False True 33243266.22847798 50187434.031790435 50707638.060852274 1.0 1.509702256296259 1.525350659358898 24.986558801437997 -11.501844825176487 0.5595468699012675 1.8682406367960508e-10 1.5238608759245833 0.9999253860401752 0.0021080628938826866 4.446231294633044 0.2764289453429903 5.415032877895165 0.002881507531912357 3.148873215711783e-12 11.501844825176487 1.5238608757377592 GFK(ub)DQIYDIFQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFKDQIYDIFQK 12 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 1 19975100.0 2978200.0 9086200.0 7910700.0 True False 3904449.0409298227 7730574.377730193 7092176.648792635 1.0 1.9799398831158006 1.816434681166609 21.89668755251918 -10.253792686302823 5.581312966549052 0.9999385471664086 1.898187282141226 0.9757490503522039 0.06675071917780279 5.1047390534381277e-05 6.824927302401586e-06 0.06463548767022219 0.021543701976902484 5.57451789181437e-11 10.253792686302823 0.8982487349748174 GFK(ub)DQIYDIFQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFKDQIYDIFQK 12 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 1 346669100.0 22264100.0 14765000.0 309640000.0 True False 33776267.42373493 12130070.390528457 248439518.27996674 1.0 0.359129984327532 7.355446212075693 25.009506570598326 -6.884506999087286 1.0543348130897354 0.5731388676835555 7.896223148221196 0.9771448328872265 0.4774085966736059 0.12370991969125444 0.24878518268029343 0.347270458859668 0.8502864167664452 1.3046469427881037e-07 6.884506999087286 7.323084280537641 up GFK(ub)DQIYDIFQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFKDQIYDIFQK 12 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 1 26336300.0 2978200.0 9970100.0 13388000.0 True False 4079321.022828778 9529588.01528824 10226030.134515043 1.0 2.336072096792228 2.5067971060105174 21.95989761404207 -10.562046199130906 0.41257161250087504 3.757614118265813e-13 2.5184774010614026 0.9993645993667527 0.0169817013775298 2.04816878379001 0.19610445873125115 2.171467131550919 0.04206129010130781 2.741282545824445e-11 10.562046199130906 2.518477401061027 GFK(ub)DQIYDIFQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFKDQIYDIFQK 12 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 1 294763100.0 22264100.0 39412000.0 233087000.0 True False 28821316.34102249 37218687.55406764 190667557.67458546 1.0 1.2913597392181857 6.615504837410946 24.780632892690775 -6.918194899038802 0.8380020519544695 0.8747099151858295 7.439418336976455 0.9936646929821135 0.20545305608376446 0.09924568174437733 0.11120257894184207 0.17534712180687548 0.5165196148436749 1.2072719241398947e-07 6.918194899038802 6.564708421790625 up GFK(ub)EQIYDVYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFKEQIYDVYR 11 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 10053400.0 2278300.0 3933100.0 3842000.0 True False 3120649.0787424697 3759322.636977584 2934598.7284737686 1.0 1.2046604863666637 0.9403808805238447 21.573414702671517 -6.7000323668697295 1.8316336310296024 1.1270886210140147 0.9411893609075029 0.41736227132644677 0.08638984325860158 0.3954373959707432 2.579422735482706 0.03763484418404901 0.09675142554772596 1.995113618654124e-07 6.7000323668697295 -0.1858992601065118 GFKDQIYDIFQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFKDQIYDIFQK 12 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 22029800.0 3653200.0 6687500.0 11689100.0 False True 4789380.577639129 5689751.067670828 10479624.061764713 1.0 1.1879930975281832 2.188095911753692 22.191407650055165 -6.938432600362822 0.6739956232085685 0.9884116336783849 2.4457878167613307 0.997951207663218 0.023602349766676103 0.08848916115485815 0.05792262721325359 0.02271084240556524 0.08668820771352714 1.1523048760612651e-07 6.938432600362822 1.4573761830829457 up GFKDQIYDIFQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFKDQIYDIFQK 12 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 21377800.0 6840000.0 1540900.0 12996900.0 False True 6622867.944026709 2156189.4056873433 9592621.991357664 1.0 0.3255673258036274 1.4484090687644517 22.659024661377252 -6.744001003549227 1.6716837464423309 0.6006079156189351 1.4497160114240935 0.6229897937261094 0.28335624591501213 0.31058765339794464 1.7055992000592786 0.13400467604827904 0.3274487417388545 1.8030135745276348e-07 6.744001003549227 0.8491080958051583 GFKDQIYDIFQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFKDQIYDIFQK 12 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 52027100.0 10056300.0 37802000.0 4168800.0 False True 15256142.31400801 31055937.7516259 3344834.85275005 1.0 2.035635032265706 0.21924512657953263 23.862886870942592 -6.75204940886677 1.6421474068961996 1.6074670362731855 0.21504439406255033 0.657754154044806 0.43523431302264215 0.29650204717266965 1.5737245796539603 0.20931017561967383 0.5070824579159939 1.769907587803874e-07 6.75204940886677 -1.3924226422106352 GFKDQIYDIFQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFKDQIYDIFQK 12 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 22183200.0 3653200.0 8786300.0 9743700.0 False True 5003886.764017902 8398092.213591345 7442438.737800583 1.0 1.678313800779945 1.4873315661972795 22.254617711578057 -10.30673920727096 5.153212753264882 0.9998440389724956 1.5828226834887007 0.9254691203815167 0.07796817077765031 0.00013974232974939496 1.879956967569051e-05 0.0755122960392696 0.02516411891296357 4.9347004250308503e-11 10.30673920727096 0.5829786445162051 GFKDQIYDIFQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFKDQIYDIFQK 12 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 14212400.0 6840000.0 3379800.0 3992600.0 False True 5687763.063378033 3361592.3465622226 4827434.200303374 1.0 0.5910218673148686 0.8487403829083381 22.43942993681153 -10.505026172997932 5.887402700599716 1.000341375325696 0.7198811251116034 0.6116787517875801 0.10521314341191856 0.00047200573979308866 3.968305667675968e-05 0.10199414541415337 0.03395739601970772 3.125890977893057e-11 10.505026172997932 -0.2804602502140926 GFKDQIYDIFQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFKDQIYDIFQK 12 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 37624000.0 10056300.0 16709300.0 10858400.0 False True 13018078.589308556 15779412.766344838 8882282.61659259 1.0 1.2121153408387089 0.682303656077741 23.63401319303504 -6.798046364538612 1.4638070920043937 1.1173263068091677 0.6753325297826416 0.8264020016037044 0.09071391253889634 0.22356221183314998 0.945910299784695 0.04875645910792915 0.11353061710901059 1.5920387546346112e-07 6.798046364538612 -0.4419937770265261 GFLALLGLQHTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFLALLGLQHTK 12 0 C9JU34;Q92766-5;Q92766-3;Q92766;Q92766-2 C9JU34 RREB1 Ras-responsive element-binding protein 1 0 5800020.0 1510600.0 975520.0 3313900.0 False True 1980411.228671211 829976.2185471779 2971009.4171734373 1.0 0.4190928664366662 1.500198228610774 20.91736860365122 -6.760719334704832 1.609494249886881 0.6628903236374246 1.5043319007883484 0.694041180897541 0.24435819791257868 0.28168820734915767 1.438294919992948 0.11977421638288914 0.28766305120958646 1.7349248406498838e-07 6.760719334704832 0.8414415771509238 GFLALLGLQHTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFLALLGLQHTK 12 0 C9JU34;Q92766-5;Q92766-3;Q92766;Q92766-2 C9JU34 RREB1 Ras-responsive element-binding protein 1 0 7409200.0 3061100.0 1824100.0 2524000.0 False True 2963927.0560614252 2552472.642555833 1862888.6816230584 1.0 0.8611793051167905 0.6285204211801801 21.49907851185544 -6.963348719170951 0.3853475228268748 1.0150509967267254 0.46635107086005195 0.9998749472500448 0.0017138538016210237 0.07852592758212534 0.016864354622546887 0.003013253900012366 0.01961068383785394 1.088056081798623e-07 6.963348719170951 -0.5486999258666734 GFLALLGLQHTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFLALLGLQHTK 12 0 C9JU34;Q92766-5;Q92766-3;Q92766;Q92766-2 C9JU34 RREB1 Ras-responsive element-binding protein 1 0 9199100.0 1510600.0 1681500.0 6007000.0 False True 2069109.6424300459 1607205.770023088 4588270.318048391 1.0 0.7767620125415493 2.217509514217787 20.98057866517411 -6.867329498081348 1.148056371953619 0.8755580557907323 2.2977382577102072 0.9619483425941042 0.12350765096809989 0.13944506414977986 0.3451692460707319 0.08361520597035056 0.19710556961230624 1.3572832885857068e-07 6.867329498081348 1.422180201919475 up GFLCNQAPHK(ub)HGFLEGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFLCNQAPHKHGFLEGR 17 1 Q9HC16 Q9HC16 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G 1 23633100.0 5248200.0 11385500.0 6999400.0 True False 7961903.094813867 9353668.569682471 5615965.522053995 1.0 1.1748031165783916 0.7053546690001865 22.924681881662472 -6.805864991320955 1.4317219579478029 1.095744521638593 0.6978876765575259 0.8487706646075153 0.07533502161718182 0.2125041552772979 0.8592393453125102 0.04138208799542381 0.09592233779245664 1.563633652280129e-07 6.805864991320955 -0.3978568450810671 GFLGCFPDIIGTHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFLGCFPDIIGTHK 14 0 Q9Y5X1 Q9Y5X1 SNX9 Sorting nexin-9 0 12910300.0 3367200.0 3009800.0 6533300.0 False True 4414431.80801118 2560749.572108511 5857296.787838872 1.0 0.5800858827315757 1.326851799411472 22.07379632644665 -6.7541645593431925 1.634788639022527 0.7543241708001681 1.328787865391895 0.6665591676412819 0.17649787115914697 0.29283291696805697 1.541026080985549 0.08524948225714565 0.2060369950212961 1.761308539207978e-07 6.7541645593431925 0.5744636945917269 GFLGCFPDIIGTHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFLGCFPDIIGTHK 14 0 Q9Y5X1 Q9Y5X1 SNX9 Sorting nexin-9 0 13596500.0 3367200.0 3780500.0 6448800.0 False True 4612144.835158505 3613465.0095583 4925726.2572050085 1.0 0.783467375528357 1.0679903674438114 22.137006387969542 -6.703276216206914 1.8193116862960603 0.8659730942845442 1.067193833626638 0.43304728630480593 0.09134788039272895 0.38876459129070295 2.503900842157612 0.04002364337567754 0.10251121782992968 1.9802671528740328e-07 6.703276216206914 0.20122073934209384 GFLSGLLDNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFLSGLLDNVK 11 0 O43615;M0QXU7;M0R301;M0R124 O43615 TIMM44 Mitochondrial import inner membrane translocase subunit TIM44 0 4184400.0 0.0 1510100.0 2674300.0 False True 0.0 1284798.9663236975 2397589.0896970127 0.0 GFLSGLLDNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFLSGLLDNVK 11 0 O43615;M0QXU7;M0R301;M0R124 O43615 TIMM44 Mitochondrial import inner membrane translocase subunit TIM44 0 9761600.0 2465400.0 4870800.0 2425400.0 False True 2387137.226491731 6815735.84088645 1790114.9795596516 1.0 2.85519230534695 0.7499003239920579 21.18685007260544 -6.674009252480084 1.9229104614464982 2.1800238012281707 0.7581915041414581 0.29706955715565764 0.7873187586663596 0.45195571370356746 3.2254406966834015 0.32916042117815103 0.8749421655771016 2.1183160048444879e-07 6.674009252480084 -1.4218322970867128 GFLSGLLDNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFLSGLLDNVK 11 0 O43615;M0QXU7;M0R301;M0R124 O43615 TIMM44 Mitochondrial import inner membrane translocase subunit TIM44 0 9974900.0 0.0 1953500.0 8021400.0 False True 0.0 1867187.9106393722 6126910.525918652 0.0 GFLSGLLDNVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFLSGLLDNVK 11 0 O43615;M0QXU7;M0R301;M0R124 O43615 TIMM44 Mitochondrial import inner membrane translocase subunit TIM44 0 5209100.0 2465400.0 1558000.0 1185700.0 False True 2050089.3357386254 1549606.744761213 1433624.3879426199 1.0 0.7558727894181773 0.6992984954122012 20.967255348039718 -13.999999999999998 0.20542000603236585 2.385975076793752 0.6644582876925934 0.9994879559930999 0.002952497151352128 12.643364319252834 0.14368567300517135 7.057363023778063 0.034620449664497975 1.0000000000000041e-14 13.999999999999998 -1.7215167891011585 GFLTSSFWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFLTSSFWR 9 0 Q53GS7 Q53GS7 GLE1 Nucleoporin GLE1 0 4012200.0 1227300.0 1484300.0 1300600.0 False True 1609002.185190108 1262848.225756085 1166026.3882361494 1.0 0.7848642080040905 0.7246891265709376 20.6177348547148 -13.999999999999766 0.17872743278722653 2.1119376292986276 0.6762556512968262 0.9994997258715124 0.002643323275958727 12.188593770254895 0.13400685341297422 4.705162966602414 0.04541975666574349 1.0000000000005399e-14 13.999999999999766 -1.4356819780018015 GFLTSSFWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFLTSSFWR 9 0 Q53GS7 Q53GS7 GLE1 Nucleoporin GLE1 0 4451450.0 1368200.0 964250.0 2119000.0 False True 1324767.2399148163 1349280.0534973214 1563970.3313626207 1.0 1.018503487136413 1.1805623540805443 20.337307471400855 -6.928450244822198 0.7593962057992425 0.9973887629744281 1.2125571718936072 0.9962250015540811 0.004983424037415122 0.09345027673226834 0.08167847953948108 0.00449899581980543 0.014790425853035137 1.1790975994483348e-07 6.928450244822198 0.2151684089191791 GFLTSSFWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFLTSSFWR 9 0 Q53GS7 Q53GS7 GLE1 Nucleoporin GLE1 0 3316200.0 1227300.0 2088900.0 0.0 False True 1681065.9765354132 1996605.4909314485 0.0 1.0 1.187702040729148 0.0 20.680944916237692 -6.9204948802248945 1.2581694651408808 1.0989868349437546 8.649197110087747e-19 0.9594221732450036 0.10501217682805468 0.12202108367839182 0.38649584927539676 0.06866428777864964 0.13402429557507767 1.2008952299462436e-07 6.9204948802248945 -1.0989868349437546 down GFLTSSFWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFLTSSFWR 9 0 Q53GS7 Q53GS7 GLE1 Nucleoporin GLE1 0 3858940.0 1368200.0 885040.0 1605700.0 False True 1137718.921537109 880272.1138533148 1941444.4460820307 1.0 0.7737166862479776 1.7064359301144898 20.11771274683513 -6.842616101094612 1.2703025680331719 0.8796380722922122 1.7387148247105504 0.9288408931609949 0.10596732258619904 0.16576709830411268 0.5184908724019707 0.06538351145553925 0.15074370337067575 1.4367589094452818e-07 6.842616101094612 0.8590767524183381 GFLVFAGCLMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFLVFAGCLMK 11 0 Q02338;C9JEB9;C9JM78;C9JQ90;A0A0G2JRX6 Q02338 BDH1 D-beta-hydroxybutyrate dehydrogenase, mitochondrial 0 5729070.0 915770.0 2194900.0 2618400.0 False True 1254354.916753716 2097922.0604363214 1999987.8476407358 1.0 1.672510732341821 1.594435371463067 20.258514182371545 -10.244399568305132 5.621856184825394 0.9999642030416446 1.6334730519024596 0.988735469297981 0.031874132606162814 1.4301945545453066e-05 1.9222386806840627e-06 0.03086373340987954 0.010287332063197208 5.696399395710724e-11 10.244399568305132 0.633508848860815 GFNCESK(ub)PEAEETCFDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFNCESKPEAEETCFDK 17 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 1 18934200.0 2647500.0 2516700.0 13770000.0 True False 3470898.1384264696 2141218.1700197654 12345212.491166983 1.0 0.6169060815453622 3.556777525244138 21.726877595872658 -6.874127697587167 1.1120968814924244 0.7768891183822262 3.742962466567957 0.968628713173167 0.23113700003057117 0.13295536952891268 0.3048439548929793 0.16086758281657437 0.3838168291466406 1.3362025690439085e-07 6.874127697587167 2.9660733481857307 up GFNCESK(ub)PEAEETCFDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFNCESKPEAEETCFDK 17 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 1 25614200.0 2647500.0 1958700.0 21008000.0 True False 3626352.2959973123 1872158.1574452687 16046343.073341206 1.0 0.5162648316082571 4.424926693154663 21.79008765739555 -6.875903343643345 1.1023383213177032 0.7137067019705274 4.681114903837188 0.9702305176262229 0.300180149108477 0.13132338360588752 0.2947111256613024 0.21047662673261686 0.5041139797292079 1.330750556182433e-07 6.875903343643345 3.967408201866661 up GFNK(ub)ETAAACVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFNKETAAACVEK 13 1 E9PGT1;Q15631 E9PGT1 TSN Translin 1 21983400.0 8188700.0 6923000.0 6871700.0 True False 12422856.574159207 5687536.560354118 5513505.48302689 1.0 0.4578284009319376 0.44381945892344415 23.56649361647495 GFNK(ub)ETAAACVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFNKETAAACVEK 13 1 E9PGT1;Q15631 E9PGT1 TSN Translin 1 7406600.0 2232600.0 3478000.0 1696000.0 True False 1856505.8209499712 3459263.3236710513 2050625.758582005 1.0 1.863319406077031 1.1045619870627192 20.824158407997835 -10.237782253732663 4.392391624149 0.9997828132630732 1.4839406961552515 0.35165840958497807 0.30976141921865413 0.00065910717865002 0.00011437631095535226 0.3000583186294928 0.09997506815685887 5.783859654760203e-11 10.237782253732663 0.4841578828921783 GFNK(ub)ETAAACVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFNKETAAACVEK 13 1 E9PGT1;Q15631 E9PGT1 TSN Translin 1 21814100.0 8188700.0 10055300.0 3570100.0 True False 10600433.573408792 9495713.71568092 2920378.432319427 1.0 0.8957854082026357 0.27549613061537426 23.3376199385674 -6.936004800640391 0.6957365249634531 1.0076714012579326 0.12620952086163212 0.9975924060692527 0.01569235797091164 0.08963742532515288 0.06326907192953596 0.014847243764928457 0.054392643790089706 1.1587645472366011e-07 6.936004800640391 -0.8814618803963006 down GFPLITITVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFPLITITVR 10 0 Q9NZ08;Q9NZ08-2 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 11339200.0 2495300.0 6423500.0 2420400.0 False True 3271362.464519578 5465138.838606884 2169960.2261162368 1.0 1.6706002156228434 0.6633200232781024 21.64146018713494 -6.727255995971672 1.7331474928181072 1.404806677907502 0.6642136949507644 0.5464334300775524 0.28197301371308253 0.34146099152173554 2.008090592266787 0.12899322094184054 0.32109784227856286 1.8738896135251272e-07 6.727255995971672 -0.7405929829567375 GFPLITITVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFPLITITVR 10 0 Q9NZ08;Q9NZ08-2 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 44632900.0 25786000.0 7807900.0 11039000.0 False True 24967437.544542775 10925635.1876606 8147554.737098637 1.0 0.43759537470230525 0.3263272301197557 24.573544426547702 -13.999999999999952 0.22779334373571541 4.514421129897934 0.27107919074443426 0.9995068609016504 0.0065480126451110555 13.223512747706636 0.15113693459781896 20.99347417575063 0.0585615437782 1.0000000000001104e-14 13.999999999999952 -4.2433419391535 GFPLITITVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFPLITITVR 10 0 Q9NZ08;Q9NZ08-2 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 369507000.0 174700000.0 94607000.0 100200000.0 False True 265032672.28077877 77723641.68213516 80395426.08077987 1.0 0.29326060448801505 0.3033415668676804 27.981594980027367 -10.03763791294814 5.144098761194895 1.0000078210139798 0.2983010856752039 0.9998452262602588 0.004115535667251563 2368846.0797126936 4622309.63263733 140.11018487795698 0.0014088577140564003 9.169846948840928e-11 10.03763791294814 -0.7017067353387758 GFPLITITVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFPLITITVR 10 0 Q9NZ08;Q9NZ08-2 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 30734700.0 2495300.0 6854400.0 21385000.0 False True 3417879.8429469718 6551549.943530328 16334303.437899912 1.0 1.9168461866937476 4.779074803231267 21.70467024865783 -6.9505524436677755 0.5527448734695042 0.9610451396723166 5.869973911827859 0.9992439304483267 0.04425592479224215 0.08326465700689549 0.035050071028666425 0.04786669400874637 0.2375717173312571 1.120592099737915e-07 6.9505524436677755 4.908928772155543 GFPLITITVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFPLITITVR 10 0 Q9NZ08;Q9NZ08-2 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 47453900.0 25786000.0 9592900.0 12075000.0 False True 21442201.51348916 9541221.143658442 14599826.671508081 1.0 0.44497395184240374 0.6808921491724353 24.35394970198198 -10.312090636044337 5.753792984859618 1.0000481348800963 0.5629330505074205 0.8206687045734591 0.09631320074931059 5.9477080074309644e-05 7.1109291493474814e-06 0.09326508704365859 0.03108495187683297 4.874267548866467e-11 10.312090636044337 -0.43711508437267577 GFPLITITVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFPLITITVR 10 0 Q9NZ08;Q9NZ08-2 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 328637000.0 174700000.0 76392000.0 77545000.0 False True 226152593.8518343 72140718.046035 63432605.67889133 1.0 0.3189913359706968 0.2804858639846055 27.752721302119816 -13.661109945849024 0.41194151935176515 9.999999784729573 0.27880506055016846 0.9998484296829065 0.004068669756974283 21.365070293075235 0.21258592889533506 170.81193211556146 0.00954342471226646 2.1821774025917566e-14 13.661109945849024 -9.721194724179405 GFPTIYFSPANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFPTIYFSPANK 12 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 305466000.0 85001000.0 75625000.0 144840000.0 False True 111437134.15085484 64342044.78394122 129853346.20338616 1.0 0.577384237976185 1.1652609984352333 26.73165482057574 -6.71376750458088 1.7815580627992758 0.7411912291867756 1.1640510836043696 0.483032146263883 0.1779872647260384 0.36757478955590034 2.276406277004243 0.07943159543184948 0.2008934548957705 1.9330028547654486e-07 6.71376750458088 0.422859854417594 GFPTIYFSPANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFPTIYFSPANK 12 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 246169000.0 77973000.0 31406000.0 136790000.0 False True 75497789.79526237 43946579.5801264 100960595.38796268 1.0 0.5820909419905181 1.337265576406293 26.169931074237493 -6.756519790380258 1.6259205045028355 0.7562026783282891 1.3395264939916258 0.676459851386175 0.17569512753875835 0.28880548426765945 1.5039873895510283 0.0852994430099691 0.20567007142463362 1.7517826053476197e-07 6.756519790380258 0.5833238156633367 GFPTIYFSPANK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFPTIYFSPANK 12 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 70925000.0 21619000.0 30781000.0 18525000.0 False True 32797603.56060763 25287890.056949306 14863525.630204067 1.0 0.7710285908608868 0.4531893802160677 24.967087068764243 -6.966513451328825 0.3310516415503622 1.0382511761403155 0.17554553458680364 0.9999410277162016 0.0017218142786738716 0.07745108013084719 0.013069158051838456 0.00462056082276942 0.027699267251750884 1.0801561648713398e-07 6.966513451328825 -0.8627056415535118 down GFPTIYFSPANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFPTIYFSPANK 12 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 260107000.0 85001000.0 75261000.0 99845000.0 False True 116428166.7656534 71935720.16515471 76263667.37232251 1.0 0.6178549586711858 0.6550276405693651 26.794864882098633 -10.05776379351255 6.378387568669966 1.000000355325865 0.6364412996202724 0.9922202059699862 0.01517568383689981 7.668394448315639e-08 1.1328121809277459e-08 0.01469380714250332 0.004897930897300198 8.754597956863671e-11 10.05776379351255 -0.36355905570559255 GFPTIYFSPANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFPTIYFSPANK 12 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 165447000.0 77973000.0 38594000.0 48880000.0 False True 64838004.28958705 38386086.461690836 59100582.00441528 1.0 0.5920306598310217 0.9115114299393512 25.95033634967177 -9.836112854992436 6.221313271959287 1.0000000142542997 0.7517710448850794 0.44595964878708594 0.13042747823318657 2.5732007833637942e-08 4.6883984934059924e-09 0.12628586935738764 0.04209528759035726 1.4584352246435132e-10 9.836112854992436 -0.24822896936922034 GFPTIYFSPANK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFPTIYFSPANK 12 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 74185000.0 21619000.0 32958000.0 19608000.0 False True 27986221.674200363 31123858.327589612 16039545.195069978 1.0 1.1121136211209868 0.5731229239085296 24.738213390856693 -6.8524349812862715 1.2233200252184366 1.0599738649084478 0.5505465198733539 0.943773694737023 0.05506246675576665 0.15479438188381822 0.444558279125056 0.03519822720722663 0.08158588869680466 1.404639958060059e-07 6.8524349812862715 -0.5094273450350939 GFPTIYFSPANKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFPTIYFSPANKK 13 1 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 144622000.0 47294000.0 26069000.0 71259000.0 False True 62002891.99574748 22179606.816166095 63885802.24459456 1.0 0.357718907977507 1.0303681036196863 25.885832172785538 -10.088162067447856 13.50775402686284 1.0000023969469898 0.6940435057985967 0.2162118633263551 0.2746078842062993 0.0 0.0 0.26588794056548737 0.08862931352182911 8.162777008267749e-11 10.088162067447856 -0.30595889114839303 GFPTIYFSPANKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFPTIYFSPANKK 13 1 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 119068400.0 38096000.0 13897400.0 67075000.0 False True 36886663.332696155 19446704.293983568 49506045.293132596 1.0 0.527201501490814 1.3421123197459468 25.136595956874327 -6.7494269955732475 1.652084215228458 0.7217928259248647 1.3436482711485032 0.6464281306410915 0.19866754070831713 0.30105848109797384 1.6165466359689094 0.09500384103317755 0.2307718244736983 1.7806272051803134e-07 6.7494269955732475 0.6218554452236384 GFPTIYFSPANKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFPTIYFSPANKK 13 1 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 48673200.0 17631500.0 23017800.0 8023900.0 False True 26748274.535309423 18910093.751107756 6437972.647999689 1.0 0.7069649941772965 0.24068739983587187 24.672942494056517 -7.168124345258651 0.4192595212455548 1.0238735754803683 1.4470490840849528e-22 0.9996739640716292 0.005645638728989539 0.08405786787781316 0.025270252815355453 0.008350139963506888 0.04239849438798859 6.790091938997939e-08 7.168124345258651 -1.0238735754803683 down GFPTIYFSPANKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFPTIYFSPANKK 13 1 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 115707000.0 47294000.0 31841000.0 36572000.0 False True 64779869.87229344 30434159.33589363 27934446.82398293 1.0 0.4698088989047262 0.4312211012317977 25.94904223430843 -13.999999999999998 0.3718802691959464 8.473014970946409 0.42733806474238795 0.9997941018960521 0.003723719147432343 23.04090328747678 0.19810720832047213 137.37583104419105 0.010721344193805727 1.0000000000000041e-14 13.999999999999998 -8.04567690620402 GFPTIYFSPANKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFPTIYFSPANKK 13 1 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 88791000.0 38096000.0 29285000.0 21410000.0 False True 31678511.938954636 29127235.892382618 25886732.011344768 1.0 0.9194635135801708 0.8171700760827785 24.917001232308603 -6.967873804641254 0.3047256913361759 1.0167736451390461 0.7166329662471178 0.9999607181568586 0.00046887521340241797 0.07699886055720043 0.011486745506308273 0.0016585621716156175 0.00912936294000177 1.0767780535529518e-07 6.967873804641254 -0.3001406788919283 GFPTIYFSPANKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFPTIYFSPANKK 13 1 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 64318500.0 17631500.0 34856000.0 11831000.0 False True 22824324.31882439 32916232.95911349 9677879.396311335 1.0 1.4421558552761091 0.42401603049118486 24.444068816148967 -6.788669641738771 1.5014375492142122 1.2475610644423392 0.41355499361661135 0.7969951461574287 0.18781574951675983 0.23737205922963478 1.0571211199252717 0.09846301133764143 0.23077186519026238 1.6267857453550986e-07 6.788669641738771 -0.8340060708257278 down GFPTWLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFPTWLK 7 0 P15311;E7EQR4 P15311 EZR Ezrin 0 6608300.0 1543600.0 1678900.0 3385800.0 False True 2023674.5482436654 1428414.6643009416 3035469.894886941 1.0 0.7058519689051057 1.4999792815111535 20.948545860646853 -6.806401069145028 1.429423991350236 0.8389938716031886 1.512781460199149 0.8502657890297388 0.12684812643262788 0.21175051367307351 0.8533514697174946 0.06978797188324165 0.16172663127549824 1.5617047486599473e-07 6.806401069145028 0.6737875885959603 GFPTWLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFPTWLK 7 0 P15311;E7EQR4 P15311 EZR Ezrin 0 5051110.0 1505900.0 876910.0 2668300.0 False True 1458096.0287879852 1227064.736025238 1969392.1827158509 1.0 0.8415527590766517 1.3506601374896212 20.475654306611826 -6.82308325104999 1.3583852421417073 0.9148531378229976 1.3625360389136585 0.8913501087733654 0.0701178204798629 0.18950294534977258 0.6862152072863752 0.04055324148373234 0.0934052317400502 1.5028538524737747e-07 6.82308325104999 0.4476829010906609 GFPTWLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFPTWLK 7 0 P15311;E7EQR4 P15311 EZR Ezrin 0 7495100.0 1543600.0 2602800.0 3348700.0 False True 2114310.6342215138 2487799.689691404 2557806.02864136 1.0 1.1766481468828294 1.2097588628849425 21.011755922169744 -13.716959439987777 0.23870845850864686 1.068955579434927e-18 1.2247377427211121 0.9995076318492793 0.002043070307092616 11.879146549291779 0.15342766007287564 5.643380832200913 0.01631523629623878 1.918847939036614e-14 13.716959439987777 1.2247377427211121 GFPTWLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFPTWLK 7 0 P15311;E7EQR4 P15311 EZR Ezrin 0 3734100.0 1505900.0 1480300.0 747900.0 False True 1252222.5726814296 1472325.3300834543 904282.4321011101 1.0 1.1757696772153776 0.7221419353308233 20.256059582046102 -6.801640837000238 1.44913386002855 1.0967820727317432 0.7156194593417768 0.8369122339897924 0.0754171334058885 0.21843916348794526 0.9054366836742466 0.040937742485783336 0.09511552950677186 1.5789164991748853e-07 6.801640837000238 -0.3811626133899664 GFQEVVTPNIFNSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFQEVVTPNIFNSR 14 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 9467800.0 2158900.0 4645700.0 2663200.0 False True 2830338.8068173416 3952579.66879677 2387637.6112182937 1.0 1.396504071977646 0.8435872078167008 21.432543331094525 -6.714290782653888 1.780610818517059 1.2426964837495007 0.8447547716931055 0.4851561015603295 0.1669775861531236 0.36650443051124143 2.267867956011766 0.07456452884301219 0.18840029178293732 1.9306751970984148e-07 6.714290782653888 -0.39794171205639517 GFQEVVTPNIFNSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFQEVVTPNIFNSR 14 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 10476200.0 2158900.0 3582500.0 4734800.0 False True 2957103.672078793 3424213.304256741 3616537.7562669376 1.0 1.1579618721482219 1.2229999882704734 21.495753392617416 -13.999999999999908 0.12191251684916758 0.2480637886780045 1.3241793684162013 0.9996836079749419 0.0016655489894955714 11.956608780192076 0.10769736211405827 2.1729338176686173 0.08979995546645196 1.0000000000002127e-14 13.999999999999908 1.0761155797381967 GFQFVSSSLPDICYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFQFVSSSLPDICYR 15 0 P62633-2;P62633;P62633-8;P62633-5;P62633-4;P62633-6 P62633-2 CNBP Cellular nucleic acid-binding protein 0 36200000.0 12533000.0 18347000.0 5320000.0 False True 16430884.36974463 15609699.116045874 4769537.433043447 1.0 0.9500218469548197 0.2902788021456678 23.96990679766496 -6.922065616885278 0.8092711567458507 1.013502027394131 0.1786692861846051 0.9947354200660259 0.023467249723608325 0.09697184030531973 0.09943184301834873 0.020443718696662384 0.06250084796211268 1.1965597312798303e-07 6.922065616885278 -0.834832741209526 down GFQFVSSSLPDICYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFQFVSSSLPDICYR 15 0 P62633-2;P62633;P62633-8;P62633-5;P62633-4;P62633-6 P62633-2 CNBP Cellular nucleic acid-binding protein 0 41683100.0 24045000.0 8095500.0 9542600.0 False True 23281704.63656754 11328075.36747479 7043106.788136369 1.0 0.4865655476825475 0.3025168001261417 24.472693357367056 -13.999999999999998 0.14283292866364458 3.4594190554656534 0.08233736523003535 0.9995918850295687 0.0059623847222890205 11.93795175932408 0.11860850096615064 8.171135458897233 0.19723608869964884 1.0000000000000041e-14 13.999999999999998 -3.377081690235618 GFQFVSSSLPDICYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFQFVSSSLPDICYR 15 0 P62633-2;P62633;P62633-8;P62633-5;P62633-4;P62633-6 P62633-2 CNBP Cellular nucleic acid-binding protein 0 68729000.0 17312000.0 35957000.0 15460000.0 False True 26263569.67673066 29540192.416676704 12404324.223641286 1.0 1.124759230381737 0.4723015331244721 24.6465596811627 -6.857184880106942 1.1999091237745962 1.0672451541234584 0.44236886869676695 0.9501196370198635 0.06315806659489837 0.1497332808765214 0.41126706813994807 0.04109784488861643 0.09564889002232511 1.3893610512779682e-07 6.857184880106942 -0.6248762854266915 down GFQFVSSSLPDICYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFQFVSSSLPDICYR 15 0 P62633-2;P62633;P62633-8;P62633-5;P62633-4;P62633-6 P62633-2 CNBP Cellular nucleic acid-binding protein 0 70195000.0 12533000.0 28233000.0 29429000.0 False True 17166788.79158991 26985572.705954082 22478476.309280157 1.0 1.5719639260182687 1.3094164891393356 24.033116859187853 -9.99985830604229 4.3389685219068905 0.9999803712298614 1.4406902075502859 0.7897638922150095 0.10718454265016585 74453909.44029881 96241932.68253537 19418.92488901818 0.03922553548633688 1.0003263156241546e-10 9.99985830604229 0.4407098363204245 GFQFVSSSLPDICYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFQFVSSSLPDICYR 15 0 P62633-2;P62633;P62633-8;P62633-5;P62633-4;P62633-6 P62633-2 CNBP Cellular nucleic acid-binding protein 0 40209000.0 24045000.0 0.0 16164000.0 False True 19994482.874111786 0.0 19543817.666108206 1.0 0.0 0.9774605219429262 24.253098632801333 -11.938065982919822 13.916401221865513 0.8627610839853294 0.5398572348743333 0.0 0.4812046810512364 0.0 0.0 0.0 0.13729359213022777 1.1532780254944484e-12 11.938065982919822 -0.322903849110996 GFQFVSSSLPDICYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFQFVSSSLPDICYR 15 0 P62633-2;P62633;P62633-8;P62633-5;P62633-4;P62633-6 P62633-2 CNBP Cellular nucleic acid-binding protein 0 45854000.0 17312000.0 16140000.0 12402000.0 False True 22410725.27053783 15241794.811799726 10144963.255266111 1.0 0.6801116263665634 0.45268339747143954 24.41768600325515 -7.857216138369302 0.15316612209394512 1.3298587825010997 6.429215106777711e-13 0.9999587092266394 0.0014425867982509367 0.1234088240595792 0.022352981540326642 0.07439125725122797 0.10048093399375509 1.389261055880368e-08 7.857216138369302 -1.3298587825004569 down GFQIAAEK(ub)QK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFQIAAEKQK 10 1 P48200 P48200 IREB2 Iron-responsive element-binding protein 2 2 844228900.0 399364000.0 442201400.0 2663500.0 True False 523570071.44647735 376226674.80755705 2387906.570096099 1.0 0.7185794133880651 0.004560815639249551 28.963807390740726 -7.388845489890015 0.7575469268196838 0.9906576082052889 2.627442983554254e-17 0.9881170804852522 0.04567281379479603 0.11185535886841069 0.1348690317541247 0.03959923390704077 0.07231528836100602 4.084646810578318e-08 7.388845489890015 -0.9906576082052889 down GFQIAAEK(ub)QK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFQIAAEKQK 10 1 P48200 P48200 IREB2 Iron-responsive element-binding protein 2 2 335478700.0 330128500.0 2435800.0 2914400.0 True False 319648751.4707051 3408427.642529192 2151031.209874103 1.0 0.010663040687151142 0.006729359022918752 28.251912217869375 GFQIAAEK(ub)QK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFQIAAEKQK 10 1 P48200 P48200 IREB2 Iron-responsive element-binding protein 2 2 760199900.0 399364000.0 357320800.0 3515100.0 True False 547019663.2062968 341533185.55412793 2684905.775756934 1.0 0.6243526668717317 0.004908243626965159 29.027017452263618 -7.590797406625309 0.6721617300807717 0.9967646199918311 1.7926672597560342e-14 0.987776498109289 0.045361475022675804 0.12063722816327621 0.14211902133797422 0.041147904180087055 0.07670608750679617 2.5656806178634557e-08 7.590797406625309 -0.9967646199918132 down GFQIAAEK(ub)QK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFQIAAEKQK 10 1 P48200 P48200 IREB2 Iron-responsive element-binding protein 2 2 337244300.0 330128500.0 2621600.0 4494200.0 True False 274516474.9222802 2607476.920453142 5433916.441167014 1.0 0.009498435098262712 0.019794500285294128 28.03231749330365 -10.50554445889941 3.5070746622520064 1.0181751244708845 0.014646467483172158 0.9999181186343884 0.0042033517129023215 28581120.041645844 39141723.6139499 5005019.318755524 0.0016136736701042346 3.1221627728141566e-11 10.50554445889941 -1.0035286569877124 GFQRPVYLFHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFQRPVYLFHK 11 1 Q7L2J0;Q7L2J0-2 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 0 18001400.0 4246400.0 6120900.0 7634100.0 False True 5567071.522196089 5207685.579081324 6844196.563458086 1.0 0.9354443459758184 1.2294069756729475 22.40848718747579 -6.849144456615462 1.2392208441548964 0.9655745623361865 1.2409653910998542 0.9390506263811561 0.03114214689876018 0.15840018902657949 0.46852773611006543 0.019668904969855256 0.0454906220511455 1.4153229317752313e-07 6.849144456615462 0.2753908287636676 GFQRPVYLFHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFQRPVYLFHK 11 1 Q7L2J0;Q7L2J0-2 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 0 8222900.0 1990400.0 2050300.0 4182200.0 False True 1927215.8414898783 2868995.482173255 3086756.3566893623 1.0 1.4886736713181605 1.6016661394310014 20.878086726847233 -11.745619966693768 0.24881996778930537 1.982315055869501e-09 1.6531786890411353 0.9993431939506243 0.00669159594214843 4.533937928667311 0.14246373149333635 2.433688920845013 0.05231986004088528 1.7963048120311767e-12 11.745619966693768 1.6531786870588203 GFQRPVYLFHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFQRPVYLFHK 11 1 Q7L2J0;Q7L2J0-2 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 0 12234500.0 4246400.0 2790800.0 5197300.0 False True 5816408.834645127 2667493.228058535 3969804.78175344 1.0 0.4586151530768874 0.6825181816841194 22.47169724899868 -10.26650820589799 5.623615629822852 1.0000322121589686 0.5705666673804963 0.8306426902917984 0.09140802865861535 3.691936257148121e-05 4.815357030714294e-06 0.08851206683617925 0.02950181439203437 5.4136701877620305e-11 10.26650820589799 -0.4294655447784723 GFQRPVYLFHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFQRPVYLFHK 11 1 Q7L2J0;Q7L2J0-2 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 0 8285600.0 1990400.0 3569900.0 2725300.0 False True 1655105.789670708 3550668.2401303337 3295147.629636525 1.0 2.145281747118266 1.9908984973656048 20.65849200228151 -10.271183850039446 5.415056713107035 0.9998792110758199 2.068090122241998 0.9845725708941242 0.0630266977879988 9.191880490578458e-05 1.2371456921520623e-05 0.06103209773980968 0.020341779241582224 5.355698865242453e-11 10.271183850039446 1.0682109111661782 GFQRPVYLFHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFQRPVYLFHK 11 1 Q7L2J0;Q7L2J0-2 Q7L2J0 MEPCE 7SK snRNA methylphosphate capping enzyme 0 16395200.0 4341400.0 3778700.0 8275100.0 False True 5620027.881787949 3568412.0232557408 6769116.709696216 1.0 0.6349456085119084 1.2044631898770397 22.4221458572112 -6.733582550340941 1.7100573270098445 0.7811925506116665 1.2043586019773416 0.5758177136285803 0.15342214592530742 0.3295746607412761 1.889665613966488 0.07104968152239022 0.1756018441237297 1.846789725260276e-07 6.733582550340941 0.4231660513656751 GFSCVK(ub)NELLPSHPLELSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFSCVKNELLPSHPLELSEK 20 1 Q9Y244 Q9Y244 POMP Proteasome maturation protein 1 33489400.0 4865400.0 15934000.0 12690000.0 True False 6378586.516600628 13556709.310245538 11376960.531075459 1.0 2.1253469361845987 1.7836178127342606 22.604805330082606 -10.436369798646822 5.237270202658929 0.9989336900963292 1.954482374459413 0.9122949327729397 0.13951033045038275 0.001738639943060488 0.00018711065108404932 0.13520859691397952 0.045026765538175736 3.661256884757365e-11 10.436369798646822 0.9555486843630839 GFSCVK(ub)NELLPSHPLELSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFSCVKNELLPSHPLELSEK 20 1 Q9Y244 Q9Y244 POMP Proteasome maturation protein 1 32920400.0 4865400.0 13067000.0 14988000.0 True False 6664269.862491159 12489656.733209431 11448143.087549413 1.0 1.8741222956029417 1.7178390617078048 22.668015391605497 -10.133418983475503 4.529584211364923 0.9999064285425882 1.795980678674736 0.9719002353842566 0.06380236313887311 44558909.42986677 8.227663356574665 43939.866553619715 0.021841245934892853 7.354971877972472e-11 10.133418983475503 0.7960742501321479 GFSDK(ub)LDFLEGDQKPLAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFSDKLDFLEGDQKPLAQR 19 2 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 13193200.0 2387700.0 1892700.0 8912800.0 True False 3130297.822519693 1610316.5376868143 7990588.953614598 1.0 0.5144291786238444 2.552660930895922 21.577868493776606 -6.843851052700006 1.264415859276507 0.7416755782437302 2.624963958799805 0.9308702164874655 0.22855740352593543 0.16434953961900198 0.5087324251583101 0.14164334789985827 0.32673082937949727 1.432679172164094e-07 6.843851052700006 1.883288380556075 up GFSDK(ub)LDFLEGDQKPLAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFSDKLDFLEGDQKPLAQR 19 2 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 16165000.0 2387700.0 5062900.0 8714400.0 True False 3270497.215166304 4839204.3372286 6656238.1987016555 1.0 1.4796540155385909 2.0352373846504523 21.641078555299497 -6.969197060294595 0.27669092394045175 0.872621977167803 2.6591231552317756 0.9999754253617991 0.0020969847513059815 0.07656409249082217 0.009959021991727914 0.010461917668484345 0.05121210592569989 1.0735022022331473e-07 6.969197060294595 1.7865011780639726 GFSDKLDFLEGDQK(ub)PLAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFSDKLDFLEGDQKPLAQR 19 2 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 6464400.0 1597700.0 1999000.0 2867700.0 True False 2094600.1721488107 1700756.9920409701 2570977.9129208094 1.0 0.8119721437319446 1.227431348047342 20.998243450619352 -6.78370225328629 1.5217990712920881 0.8940437889791477 1.2310912320322531 0.7801454150250371 0.07964722430768467 0.2448719973456977 1.120358150090132 0.04121567837098406 0.09694070597870127 1.6454994698692413e-07 6.78370225328629 0.3370474430531054 GFSDKLDFLEGDQK(ub)PLAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFSDKLDFLEGDQKPLAQR 19 2 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 33344800.0 8754100.0 9662700.0 14928000.0 True False 13280609.710435977 7938315.689980305 11977474.256825157 1.0 0.5977372924183091 0.9018768353242992 23.662818046290223 -9.749809259169657 5.836356527775052 1.0000000126391002 0.7498070638695387 0.47431601681871594 0.12416444846009282 2.0303420616966763e-08 4.604182152560999e-09 0.12022171564082494 0.04007390342216637 1.7790605965425899e-10 9.749809259169657 -0.25019294876956155 GFSDKLDFLEGDQK(ub)PLAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFSDKLDFLEGDQKPLAQR 19 2 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 11216700.0 2749100.0 2816500.0 5651100.0 True False 2285998.4557796135 2801326.9554685215 6832718.882265784 1.0 1.2254281923883283 2.9889429124463534 21.124392998318452 -6.930515148992877 0.7425551930893172 0.9736884211175513 3.3557745173690186 0.9966384684059129 0.051556870402755736 0.09237122797030516 0.07637718889040879 0.04711550535417922 0.15911805618907582 1.1735047477664327e-07 6.930515148992877 2.3820860962514674 up GFSLLATEDKEALKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFSLLATEDKEALKK 15 2 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 21224500.0 5317200.0 9706200.0 6201100.0 False True 6970900.691838048 8258072.794471263 5559469.657151452 1.0 1.1846493243176328 0.7975252987983052 22.7329136443127 -6.776994374441789 1.547443601001964 1.1049628165150078 0.7947362208265641 0.7566342884340626 0.07799335540648994 0.2552853921277378 1.207191601088143 0.03970467338158864 0.09392983793835612 1.6711122606332026e-07 6.776994374441789 -0.3102265956884437 GFSLLATEDKEALKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFSLLATEDKEALKK 15 2 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 6661100.0 2265000.0 1704300.0 2691800.0 False True 2193098.814798318 2384835.8778070915 1986736.827730962 1.0 1.0874274618703883 0.9059039265924125 21.06453938653759 -6.775780004548838 1.5526932065262067 1.0497761004243404 0.9046613898894399 0.752032197515444 0.03691072909494174 0.2571934803806336 1.2244547306646059 0.018730763826292695 0.04434821405142551 1.6757915470850052e-07 6.775780004548838 -0.14511471053490055 GFSLLATEDKEALKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFSLLATEDKEALKK 15 2 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 16460800.0 5317200.0 9090000.0 2053600.0 False True 7283112.531927071 8688373.74338976 1568581.9752196055 1.0 1.1929478921686885 0.21537247548261726 22.79612370583559 -6.85545097752006 1.2085437152973593 1.103664143790804 0.17199564524262104 0.9478577795215019 0.09653551869200318 0.15156763072757923 0.4232812529904693 0.062405659988590205 0.14500291498615012 1.3949191050343092e-07 6.85545097752006 -0.9316684985481829 down GFSMPGFLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFSMPGFLFK 10 0 E7EWP2;O75962-5;O75962-2;O75962-4;O75962;E7EPJ7 E7EWP2 TRIO Triple functional domain protein 0 1348050.0 415970.0 412340.0 519740.0 False True 545340.69825921 350820.4792887316 465962.2904981209 1.0 0.6433051492554852 0.8544425383719314 19.056798300874654 -10.257635483404963 5.5583055713379785 1.000018776001907 0.7488738438137 0.6535260621090138 0.08619647815982161 2.0057159695583473e-05 2.6788487657086835e-06 0.08346561592346483 0.02781979370122248 5.5254100921867084e-11 10.257635483404963 -0.251144932188207 GFSTWLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFSTWLK 7 0 P26038;V9GZ54 P26038 MSN Moesin 0 31089200.0 7158200.0 6175000.0 17756000.0 False True 9384469.5201074 5253714.069961472 15918779.447578862 1.0 0.559830692475982 1.6962897490871367 23.161843764850143 -6.801679779017151 1.4489769669276247 0.7576518853786557 1.7126474774748963 0.8370412712811436 0.18886980617437038 0.2183723458376466 0.9049596939941595 0.10253346203168456 0.23822246757320842 1.5787749283306555e-07 6.801679779017151 0.9549955920962406 GFSTWLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFSTWLK 7 0 P26038;V9GZ54 P26038 MSN Moesin 0 23240900.0 4950000.0 2565900.0 15725000.0 False True 4792864.959493009 3590477.250991731 11606150.760111956 1.0 0.7491296502899035 2.4215476251055605 22.192456861458325 -6.868710133436806 1.140973322446293 0.8591805893159399 2.5170896574067276 0.9633748365834199 0.1409322142880473 0.13809356965618433 0.33681069946044906 0.09593807530983893 0.2266300309770728 1.3529752950150805e-07 6.868710133436806 1.6579090680907878 up GFSTWLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFSTWLK 7 0 P26038;V9GZ54 P26038 MSN Moesin 0 11833600.0 4681800.0 5196000.0 1955800.0 False True 7102632.885427314 4268733.203466707 1569235.2727424086 1.0 0.6010071578139701 0.22093712262139523 22.759922487833826 -7.653455460863902 0.33595799632426204 1.0738560724446857 2.3008028738162465e-21 0.9992679590586836 0.008606115533071014 0.12379017098105737 0.046319352830229865 0.02895762276479821 0.07451703316193613 2.220979444653459e-08 7.653455460863902 -1.0738560724446857 down GFSTWLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFSTWLK 7 0 P26038;V9GZ54 P26038 MSN Moesin 0 20566900.0 7158200.0 5914400.0 7494300.0 False True 9804779.983081378 5653082.251694649 5724300.689953395 1.0 0.5765639067321567 0.5838275514423529 23.225053826373035 -10.51585628596771 9.503439021650058 1.0000105200205613 0.5801957290874175 0.9997755183278252 0.002965370535474455 6.609839241778282e-07 3.366752042398482e-08 0.0028712794866369196 0.0009570692249355632 3.0489037470023226e-11 10.51585628596771 -0.4198147909331439 GFSTWLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFSTWLK 7 0 P26038;V9GZ54 P26038 MSN Moesin 0 12115100.0 4950000.0 3781900.0 3383200.0 False True 4116144.322181468 3761526.154051626 4090611.4778506155 1.0 0.913847003318411 0.9937969025543496 21.9728621368926 -10.296366610326366 5.339931656658994 1.0000080738386519 0.9538219530460808 0.30786720715675164 0.03263940968584035 3.137897189967655e-06 4.134844194296368e-07 0.03160849780344229 0.010534324178606908 5.053978495424222e-11 10.296366610326366 -0.04618612079257112 GFSTWLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFSTWLK 7 0 P26038;V9GZ54 P26038 MSN Moesin 0 12256900.0 4681800.0 4590100.0 2985000.0 False True 6060682.392075096 4334656.899977817 2441760.628686446 1.0 0.7152093806541954 0.4028854295152101 22.531048809926276 -6.9699402376708495 0.2596131940668732 1.0881003367309232 0.020733013379801393 0.9999819111903495 0.0010371322838677837 0.07632213390301862 0.0090996829362798 0.006536162049405267 0.029485370401663488 1.0716667648490986e-07 6.9699402376708495 -1.0673673233511218 down GFSVLHTYQDHLWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFSVLHTYQDHLWR 14 0 P41214;Q5SY38 P41214 EIF2D Eukaryotic translation initiation factor 2D 0 15381300.0 5460400.0 2824400.0 7096500.0 False True 7158637.278588818 2403010.5294249724 6362222.254434748 1.0 0.3356798837415992 0.8887476773636632 22.77125355087325 -10.287460641478884 8.010363665818792 1.0000007601389465 0.6122137805527017 0.39594960491968156 0.22578898125682825 3.065330964124459e-06 2.72478833331982e-07 0.2186196710122871 0.07287308034706955 5.1586891426760516e-11 10.287460641478884 -0.38778697958624475 GFSVVADTPELQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFSVVADTPELQR 13 0 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 0 22894500.0 6307400.0 8793000.0 7794100.0 False True 8269062.480948479 7481118.674845553 6987641.298286455 1.0 0.9047118330622957 0.8450342846466142 22.979292339983417 GFSVVADTPELQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFSVVADTPELQR 13 0 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 0 19621800.0 5409800.0 3599000.0 10613000.0 False True 5238068.860174803 5036099.468537065 7833136.916824688 1.0 0.9614420128812514 1.4954245783938174 22.320603594950008 -6.889539849911191 1.0250669121457647 0.970991267287006 1.540945918847241 0.980603330050435 0.03386308765642573 0.11951870283560934 0.22401807830784226 0.02518528843157928 0.06268626015033868 1.2896152201993902e-07 6.889539849911191 0.569954651560235 GFSVVADTPELQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFSVVADTPELQR 13 0 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 0 23841200.0 6307400.0 8030200.0 9503600.0 False True 8639416.231075894 7675399.211679695 7259045.412785862 1.0 0.8884164168490182 0.8402240635976246 23.042502401506308 -13.999999975587688 0.11442306385805928 1.5348144766860168 0.757191187117372 0.9997206789061506 0.0011183732551728889 11.98848712476187 0.10334180682698993 1.469924552574137 0.07369153101495708 1.0000000562114276e-14 13.999999975587688 -0.7776232895686448 GFSVVADTPELQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFSVVADTPELQR 13 0 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 0 11395900.0 5409800.0 4069100.0 1917000.0 False True 4498488.394775213 4047178.9506468843 2317835.836793456 1.0 0.8996753121220666 0.5152477084270165 22.101008870384284 -6.945862217114842 0.6025624114608709 1.004306790879754 0.3908504747502026 0.9988352504624376 0.007130165942795729 0.08519106874128095 0.04317556460380988 0.007299622984695354 0.032333563165156905 1.1327596819660044e-07 6.945862217114842 -0.6134563161295514 GFTAAGILSAHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFTAAGILSAHK 12 0 A0A087WTV6;Q96C36;J3KR12 A0A087WTV6 PYCR2 Pyrroline-5-carboxylate reductase 2 0 46583100.0 18262400.0 17678900.0 10641800.0 False True 23942183.25333319 15041277.031812452 9540688.619353723 1.0 0.6282333099141421 0.3984886640622252 24.51305137978205 -8.797295890525175 0.150873477957812 1.4648142221860134 1.8129621446282475e-14 0.9998653694590477 0.0028756577906285 0.3212411372479569 0.044111237843159734 0.22769376020037788 0.16095367853570774 1.5947922241573889e-09 8.797295890525175 -1.4648142221859952 GFTAAGILSAHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFTAAGILSAHK 12 0 A0A087WTV6;Q96C36;J3KR12 A0A087WTV6 PYCR2 Pyrroline-5-carboxylate reductase 2 0 24333500.0 8639600.0 3906100.0 11787800.0 False True 8365340.6270779455 5465826.1000424065 8700221.553580133 1.0 0.6533895442762916 1.0400319534411073 22.9959928556716 -6.670455756422876 1.9364248611186687 0.7788403026657283 1.0384502278834422 0.2808468556152285 0.1472181227487294 0.4600299185517131 3.32626280244429 0.061205266948427275 0.16338826166590154 2.1357196505526629e-07 6.670455756422876 0.25960992521771387 GFTAAGILSAHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFTAAGILSAHK 12 0 A0A087WTV6;Q96C36;J3KR12 A0A087WTV6 PYCR2 Pyrroline-5-carboxylate reductase 2 0 34158000.0 18262400.0 8637900.0 7257700.0 False True 25014502.802803166 8256249.0162845235 5543580.737023433 1.0 0.33005848972378193 0.22161466812773148 24.57626144130494 -13.99999999999964 0.2562696178396334 5.810389908726514 0.180539761290222 0.9995548190779201 0.007263070644862153 14.255410067180742 0.16018798562844408 35.43303709106303 0.048360394333896425 1.0000000000008304e-14 13.99999999999964 -5.629850147436292 GFTAAGILSAHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFTAAGILSAHK 12 0 A0A087WTV6;Q96C36;J3KR12 A0A087WTV6 PYCR2 Pyrroline-5-carboxylate reductase 2 0 21310900.0 8639600.0 8356700.0 4314600.0 False True 7184210.199175563 8311680.798424925 5216762.91154358 1.0 1.1569373066755129 0.7261428559178627 22.776398131105875 -6.808132579791347 1.4224182320232255 1.0857198374533739 0.7189273531490749 0.8548839119016846 0.06781403626687457 0.2093579879837495 0.8352086105673662 0.03749147188356069 0.08679918918941086 1.555490704745715e-07 6.808132579791347 -0.366792484304299 GFTAAGILSAHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFTAAGILSAHK 12 0 A0A087WTV6;Q96C36;J3KR12 A0A087WTV6 PYCR2 Pyrroline-5-carboxylate reductase 2 0 37559600.0 6837700.0 20267300.0 10454600.0 False True 8851537.441217456 19139406.93861144 8551970.07325471 1.0 2.16226921771671 0.9661564592646017 23.077496630867763 -6.652722725722423 1.9985437425527242 1.7525819118856338 0.9711658154974512 0.20514484599185756 0.4957423292539431 0.5019865494485883 3.8461414245951673 0.20094339803795117 0.5492765346977891 2.2247298107797321e-07 6.652722725722423 -0.7814160963881827 GFTAAGVLAAHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFTAAGVLAAHK 12 0 P32322-2;P32322;P32322-3;E2QRB3;J3KQ22;J3QL24;J3QR88;J3QLK9;J3QL23;J3QL32;J3KTA8;J3QKT3;J3QRZ0 P32322-2 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial;Pyrroline-5-carboxylate reductase 0 45548200.0 9139700.0 14230500.0 22178000.0 False True 11982235.2089807 12107364.870054537 19883233.30639807 1.0 1.010442931464077 1.6593926725370542 23.51439372293233 -6.9103971383013 0.8930285734420083 0.9801585996668893 1.7439740853231147 0.9910704760605947 0.029143439872673548 0.1041560411703772 0.1373482206442991 0.0239070498054867 0.06617705929503284 1.2291442722396967e-07 6.9103971383013 0.7638154856562254 GFTAAGVLAAHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFTAAGVLAAHK 12 0 P32322-2;P32322;P32322-3;E2QRB3;J3KQ22;J3QL24;J3QR88;J3QLK9;J3QL23;J3QL32;J3KTA8;J3QKT3;J3QRZ0 P32322-2 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial;Pyrroline-5-carboxylate reductase 0 26685800.0 10451200.0 3889100.0 12345500.0 False True 10119432.376697654 5442037.911388579 9111843.19293878 1.0 0.5377809454925689 0.9004302666146491 23.270625032278325 -9.851712330421002 6.413306723069501 1.0000000121400938 0.7191056060535669 0.4444223594898655 0.14805096538612242 2.5585111738589214e-08 4.6629747028975445e-09 0.14334973724075606 0.04778324361084275 1.406979175590561e-10 9.851712330421002 -0.28089440608652694 GFTAAGVLAAHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFTAAGVLAAHK 12 0 P32322-2;P32322;P32322-3;E2QRB3;J3KQ22;J3QL24;J3QR88;J3QLK9;J3QL23;J3QL32;J3KTA8;J3QKT3;J3QRZ0 P32322-2 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial;Pyrroline-5-carboxylate reductase 0 32603900.0 6373800.0 20062700.0 6167400.0 False True 9669520.587196503 16482354.434409453 4948410.686732548 1.0 1.7045679034215908 0.5117534672075451 23.20501293228175 -6.746648257033561 1.6621609535992363 1.4159550962422798 0.5099634564403944 0.6344574340385044 0.2960287443734093 0.30592902805274264 1.6618619835929307 0.14075215122056242 0.3429311852161794 1.792056685594367e-07 6.746648257033561 -0.9059916398018854 GFTAAGVLAAHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFTAAGVLAAHK 12 0 P32322-2;P32322;P32322-3;E2QRB3;J3KQ22;J3QL24;J3QR88;J3QLK9;J3QL23;J3QL32;J3KTA8;J3QKT3;J3QRZ0 P32322-2 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial;Pyrroline-5-carboxylate reductase 0 33601000.0 9139700.0 6797100.0 17664200.0 False True 12518894.081105435 6496781.646996087 13492279.765618518 1.0 0.5189581128257627 1.0777533285453862 23.57760378445522 -6.678933080776604 1.905843149489779 0.6953406828786067 1.0755990292017197 0.31913174091407637 0.20392607073270957 0.44092323240053893 3.095532649327699 0.08589059212568795 0.22682707991209086 2.0944351566501332e-07 6.678933080776604 0.38025834632311295 GFTAAGVLAAHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFTAAGVLAAHK 12 0 P32322-2;P32322;P32322-3;E2QRB3;J3KQ22;J3QL24;J3QR88;J3QLK9;J3QL23;J3QL32;J3KTA8;J3QKT3;J3QRZ0 P32322-2 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial;Pyrroline-5-carboxylate reductase 0 22015220.0 10451200.0 6766800.0 4797220.0 False True 8690635.866663232 6730345.905295367 5800296.522160827 1.0 0.7744365324420711 0.6674191176747404 23.0510303077126 -13.999999999999611 0.09907165848639321 2.1170538750463996 0.4361671718018607 0.9997983582000024 0.001968416320798247 12.087584379540873 0.093547823898473 2.7672293609395155 0.20635914051846618 1.0000000000008958e-14 13.999999999999611 -1.680886703244539 GFTAAGVLAAHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFTAAGVLAAHK 12 0 P32322-2;P32322;P32322-3;E2QRB3;J3KQ22;J3QL24;J3QR88;J3QLK9;J3QL23;J3QL32;J3KTA8;J3QKT3;J3QRZ0 P32322-2 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial;Pyrroline-5-carboxylate reductase 0 33176300.0 6373800.0 18444300.0 8358200.0 False True 8251009.746381355 17417858.491157256 6837093.362374215 1.0 2.1109972023480164 0.8286371695746401 22.9761392543742 -6.677566122994494 1.9103480109606783 1.7044604391066531 0.8335832183187063 0.31310852431471536 0.4711177987746013 0.44394872652247813 3.1302158447658526 0.19803115697460463 0.5239639354224906 2.1010378536510148e-07 6.677566122994494 -0.8708772207879468 GFTIPEAFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFTIPEAFR 9 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 29735300.0 6141300.0 12055000.0 11539000.0 False True 8051303.772433794 10256440.990021959 10345054.969903829 1.0 1.2738857307978064 1.2848918960583033 22.9407909915232 -12.110265191522325 0.4918086236241443 5.69905744358243e-06 1.2844359958822884 0.9998962617845473 0.001342210759318206 7.056741266343056 0.24441427896594634 7.375600252811467 0.0022761579298213206 7.757732646089888e-13 12.110265191522325 1.2844302968248449 GFTIPEAFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFTIPEAFR 9 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 20121100.0 9244300.0 2657700.0 8219100.0 False True 8950844.75657399 3718933.4697224097 6066271.14228529 1.0 0.4154840767393515 0.6777316898307155 23.09359241579137 -10.399572997214227 6.006663886753696 1.000112178794938 0.5466078832850452 0.7994112104101357 0.10706213972277867 0.00016087484788038047 1.608124063568638e-05 0.10368786695365315 0.03455415701297101 3.984987860925187e-11 10.399572997214227 -0.4535042955098929 GFTIPEAFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFTIPEAFR 9 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 25471500.0 6141300.0 10047000.0 9283200.0 False True 8411904.572392177 9603090.319013953 7090699.35350538 1.0 1.141607139782736 0.8429362568825395 23.004001053046093 -6.777776471743929 1.5444282691183648 1.0804153180077678 0.8407298689152295 0.7594394218314456 0.0598305859743402 0.25406673380618616 1.1968199609282033 0.030516155146119894 0.07214347582543322 1.6681055536097346e-07 6.777776471743929 -0.2396854490925383 GFTIPEAFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFTIPEAFR 9 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 12701000.0 9244300.0 1981300.0 1475400.0 False True 7687045.041927712 1970626.3436427438 1783899.3185211641 1.0 0.25635680978767383 0.23206567787637267 22.873997691225647 GFTIPEAFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFTIPEAFR 9 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 11606400.0 3923800.0 3855600.0 3827000.0 False True 5079436.449661288 3641032.4706552085 3130525.268336021 1.0 0.7168181956283759 0.6163135023659512 22.276237011916272 -13.999999999999998 0.14430428400591952 2.3587315028094027 0.49815520199298485 0.9995863444035428 0.0033039774384028093 11.940864663209847 0.11931368485753287 4.558763533917037 0.10596706594041486 1.0000000000000041e-14 13.999999999999998 -1.8605763008164178 GFTPIPGTIEMLHPWNNEGAPPEDK(ub)VVPSFLPVDQGGSLVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFTPIPGTIEMLHPWNNEGAPPEDKVVPSFLPVDQGGSLVGR 42 1 Q14126 Q14126 DSG2 Desmoglein-2 1 64868000.0 14607000.0 13223000.0 37038000.0 True False 18909049.447016265 12487128.426048813 30297464.041972704 1.0 0.660378432085554 1.6022732463028946 24.172573505418615 -6.809176567590028 1.4180387832916892 0.8147295720985822 1.618435585942487 0.8576565827631486 0.1469441203763326 0.20792495737797884 0.8242064676670834 0.08148537420523551 0.1885596019248722 1.5517559968263252e-07 6.809176567590028 0.8037060138439048 GFVFITFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFVFITFK 8 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 214693900.0 54741500.0 92589000.0 67363400.0 False True 71766636.61744006 78775082.10909525 60393281.563360795 1.0 1.0976560393796142 0.8415230866299868 26.09680997381583 -6.803350417875422 1.4420021416026678 1.053653672558248 0.8376796126500384 0.8418436277829081 0.04197364422177961 0.2159996971202125 0.8863068580347851 0.022894590108471873 0.053144108090540626 1.5727133818923292e-07 6.803350417875422 -0.2159740599082095 GFVFITFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFVFITFK 8 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 307815000.0 139193000.0 90331000.0 78291000.0 False True 134774394.4053961 126400639.3699419 57784238.420345046 1.0 0.9378683534628524 0.428747898851857 27.00597118608364 -6.92965215678812 0.7496425419257633 1.0078429143527525 0.32514818941343065 0.9964694254493475 0.01520561088678475 0.09281885978858032 0.07856814441415046 0.013824483638087677 0.04615505835977228 1.175838952686284e-07 6.92965215678812 -0.6826947249393218 down GFVFITFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFVFITFK 8 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 838962000.0 275325000.0 273643000.0 289994000.0 False True 417688153.95366603 224809268.66748238 232676558.79111466 1.0 0.5382227543192915 0.5570580745196939 28.637850986931312 -10.431627853497906 9.28824224827545 1.0000023785134662 0.5476404144296855 0.9987013994370155 0.007689487272153771 3.787387875183192e-07 2.3172660481013542e-08 0.007445353180437294 0.0024817713454937935 3.701452209900488e-11 10.431627853497906 -0.4523619640837807 GFVFITFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFVFITFK 8 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 370574500.0 54741500.0 118082000.0 197751000.0 False True 74980911.88341336 112864746.7950437 151046286.60968646 1.0 1.505246388181239 2.014463185571095 26.16002003533872 -6.971028096463306 0.2323242398744284 0.7988321598174429 2.7354680421204507 0.9999893279384363 0.0013529507307998604 0.07597051577355265 0.007826334890481986 0.012862923027870135 0.050349905030430346 1.0689857194915178e-07 6.971028096463306 1.9366358823030079 GFVFITFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFVFITFK 8 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 294281300.0 139193000.0 62735300.0 92353000.0 False True 115745146.79543543 62397332.4869179 111663585.307974 1.0 0.5390924303478323 0.9647366511645187 26.786376461517918 -10.484395379369431 8.991763441645011 1.0000057333246188 0.7519145407561755 0.31174388974292466 0.17376852549423524 1.9972555222297688e-05 1.1454667732531902e-06 0.16825453758622497 0.05608355044451601 3.277967328406182e-11 10.484395379369431 -0.24809119256844336 GFVFITFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFVFITFK 8 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 718314000.0 275325000.0 254967000.0 188022000.0 False True 356413639.9671226 240777862.31599385 153803925.26863763 1.0 0.6755573729956138 0.43153209647875784 28.40897730902376 -7.6387473074143575 0.17210211438679257 1.2637188578990024 5.064640558051581e-10 0.9999602123070529 0.0014687404126553546 0.134320271830883 0.019395893006899517 0.04779069279997256 0.0795028099567391 2.2974850421840305e-08 7.6387473074143575 -1.2637188573925384 down GFVFITFKEEEPVKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFVFITFKEEEPVKK 15 2 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 6095800.0 2293900.0 1095600.0 2706300.0 False True 3007325.1141592013 932140.7506153503 2426278.0366626857 1.0 0.30995676065305017 0.8067894040585077 21.520049411705962 -9.903529649980099 6.3543077449507965 1.0000000476151856 0.5583730823562303 0.5130236774001806 0.2028310773170648 1.3696199646047789e-07 2.3718068983507365e-08 0.19639036808374613 0.0654634487118371 1.2487351885281215e-10 9.903529649980099 -0.4416269652589553 GFVFITFKEEEPVKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFVFITFKEEEPVKK 15 2 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 7428600.0 1906300.0 1434400.0 4087900.0 False True 1845785.5499558619 2007163.4002971812 3017156.3556287237 1.0 1.087430444097462 1.6346191223031694 20.815803514514094 -6.934948421048622 0.7049895945147254 0.993007006336519 1.7625577394700234 0.9974245876304458 0.01425182202592582 0.09014842431003202 0.0656808928218509 0.013390200239967892 0.04823527983314739 1.161586561388843e-07 6.934948421048622 0.7695507331335044 GFVFITFKEEEPVKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFVFITFKEEEPVKK 15 2 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 70562000.0 14211000.0 25703000.0 30648000.0 False True 21559125.963263564 21116098.831544377 24590409.366504394 1.0 0.9794505986711104 1.1406032604664071 24.36179535463843 -6.8748897510230815 1.1079652320094417 0.9879535446203334 1.1509587583920253 0.9693214522099681 0.012544032255970205 0.1322499566407616 0.3004965094130282 0.008758120855166914 0.020929259628771048 1.3338599997535132e-07 6.8748897510230815 0.16300521377169197 GFVFITFKEEEPVKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFVFITFKEEEPVKK 15 2 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 11005700.0 2293900.0 4738200.0 3973600.0 False True 3142016.8203166164 4528850.656867906 3035117.518860845 1.0 1.4413833266530829 0.9659774891195524 21.583259473228853 -6.662786418174038 1.962538779640889 1.2834456092284168 0.9679268363837473 0.24776766142579065 0.18780386661864265 0.4778333993150331 3.5406255111257896 0.07722672496417624 0.2083216266419295 2.173769955075796e-07 6.662786418174038 -0.31551877284466945 GFVFITFKEEEPVKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFVFITFKEEEPVKK 15 2 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 63091000.0 14211000.0 23973000.0 24907000.0 False True 18396419.64068927 22638881.47603933 20374181.56740145 1.0 1.230613451867915 1.1075079806473733 24.13292167673088 -10.250147765858012 4.073191679976538 0.9998551261008619 1.1690607162715687 0.7154728421272363 0.050257598281524485 6.814910662577067e-05 1.2545906868077777e-05 0.04870455746134017 0.01622057008126841 5.621500247772933e-11 10.250147765858012 0.1692055901707068 GFVLQDTVEQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFVLQDTVEQLR 12 0 P56192;P56192-2;H0YHV5;H0YIC2 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 7232270.0 2700700.0 800370.0 3731200.0 False True 2614967.7567884424 1119961.9148744107 2753886.7863993463 1.0 0.42828899590329383 1.0531245669283191 21.318361727112567 -6.666062233028698 1.9517057331118977 0.6338376647403259 1.0505379363972724 0.26152599628394846 0.24307556495379762 0.4702479755590514 3.44956478129368 0.10041115963684778 0.269621927417478 2.1574352333407942e-07 6.666062233028698 0.41670027165694656 GFVQIWDAAAGK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFVQIWDAAAGKK 13 1 K7EQT1;Q9UM11-3;Q9UM11-2;Q9UM11 K7EQT1 FZR1 Fizzy-related protein homolog 1 59634300.0 11347000.0 9312300.0 38975000.0 True False 10986795.696033766 13030749.953002952 28766278.27506285 1.0 1.1860373409607547 2.6182591422399417 23.389267349179136 -6.930818252652509 0.7400485588530842 0.9788683552436607 2.9185052601417216 0.9966965906352612 0.041554949633775554 0.09221510449182414 0.07561592115397898 0.03804453035748007 0.12901311186564898 1.1726860187607749e-07 6.930818252652509 1.939636904898061 up GFVQIWDAAAGK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFVQIWDAAAGKK 13 1 K7EQT1;Q9UM11-3;Q9UM11-2;Q9UM11 K7EQT1 FZR1 Fizzy-related protein homolog 1 114552000.0 41962000.0 34037000.0 38553000.0 True False 63659421.83311986 27962831.417705208 30932982.651619844 1.0 0.43925676062544894 0.485913659924672 25.923870718416307 -10.030397902833855 7.587037217115657 1.0000000236538997 0.46258521178809436 0.9943788432354804 0.019047599377252554 7.61680211182297e-09 9.779971494602978e-10 0.01844275961778487 0.006147586264444161 9.323996399976509e-11 10.030397902833855 -0.5374148118658053 GFVQIWDAAAGK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFVQIWDAAAGKK 13 1 K7EQT1;Q9UM11-3;Q9UM11-2;Q9UM11 K7EQT1 FZR1 Fizzy-related protein homolog 1 156349000.0 41962000.0 101542000.0 12845000.0 True False 54320636.19468044 95891098.43740821 10507341.800829947 1.0 1.7652793699569873 0.19343186193866632 25.694997040508756 -6.774291975151433 1.557880825754947 1.4365178683411235 0.18307785621654984 0.7467981394173688 0.322937269863427 0.25952026626087243 1.2435556034572814 0.1633340769077282 0.38731558308297587 1.6815431834708636e-07 6.774291975151433 -1.2534400121245737 GFVVINQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GFVVINQK 8 0 P40227;P40227-2;Q92526;Q92526-2;Q92526-3 P40227;P40227-2;Q92526 CCT6A;CCT6B T-complex protein 1 subunit zeta;T-complex protein 1 subunit zeta-2 0 36504800.0 9315000.0 8017800.0 19172000.0 False True 12212055.206588319 6821575.493139616 17188265.350809984 1.0 0.55859356821933 1.4074834301057724 23.54180268082196 -6.765372312256732 1.5920720809360862 0.7453359610965007 1.411459118821147 0.7126273980909894 0.18582920141184928 0.2739556968472842 1.369630868304738 0.09204238718965602 0.22005086568956 1.7164362886258243e-07 6.765372312256732 0.6661231577246463 GFVVINQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GFVVINQK 8 0 P40227;P40227-2;Q92526;Q92526-2;Q92526-3 P40227;P40227-2;Q92526 CCT6A;CCT6B T-complex protein 1 subunit zeta;T-complex protein 1 subunit zeta-2 0 22473200.0 8123100.0 2497100.0 11853000.0 False True 7865236.636860134 3494205.052204472 8748343.717622068 1.0 0.44425936733155774 1.1122797852798587 22.907058741155712 -6.685921916948252 1.8811843389534406 0.6502544264598071 1.1098457638641026 0.3512681974464241 0.23523867061324794 0.4255031578138913 2.9162368401468286 0.10016400885804183 0.262156007365304 2.0610004331455325e-07 6.685921916948252 0.4595913374042955 GFVVINQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GFVVINQK 8 0 P40227;P40227-2;Q92526;Q92526-2;Q92526-3 P40227;P40227-2;Q92526 CCT6A;CCT6B T-complex protein 1 subunit zeta;T-complex protein 1 subunit zeta-2 0 34783300.0 4887200.0 27189000.0 2707100.0 False True 7414239.702178728 22336910.52137341 2172040.49843592 1.0 3.012704123230538 0.29295525713818643 22.821867327528768 -6.708499341105008 1.80073678301895 2.2392769420796914 0.2996825065415862 0.4578791683691572 0.8483460066167946 0.3781060732700954 2.3891059052255383 0.37505376461854456 0.9544856046742787 1.9565937364019337e-07 6.708499341105008 -1.9395944355381052 GFVVINQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GFVVINQK 8 0 P40227;P40227-2;Q92526;Q92526-2;Q92526-3 P40227;P40227-2;Q92526 CCT6A;CCT6B T-complex protein 1 subunit zeta;T-complex protein 1 subunit zeta-2 0 34210000.0 9315000.0 13007000.0 11888000.0 False True 12759007.22840981 12432307.731602903 9080299.241045326 1.0 0.9743945989716613 0.7116775685201198 23.60501274234485 -6.925779910697764 0.7806527366073 1.0046812477067373 0.6631150648914242 0.9956418579835616 0.00860199356160462 0.09488906420173193 0.08885399136578949 0.00764831804415831 0.02434620438228383 1.1863698176399918e-07 6.925779910697764 -0.34156618281531304 GFVVINQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GFVVINQK 8 0 P40227;P40227-2;Q92526;Q92526-2;Q92526-3 P40227;P40227-2;Q92526 CCT6A;CCT6B T-complex protein 1 subunit zeta;T-complex protein 1 subunit zeta-2 0 13969400.0 8123100.0 3357300.0 2489000.0 False True 6754717.564345916 3339213.5585281295 3009438.392164279 1.0 0.4943528025736895 0.4455313436122468 22.68746401658999 -13.999999999999998 0.3305753447219808 6.523425312196411 0.4369432276876131 0.9997160348488087 0.004224024641342446 18.872016904131073 0.18388785577952071 72.4947607921587 0.015611488444291971 1.0000000000000041e-14 13.999999999999998 -6.086482084508798 GFVVINQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GFVVINQK 8 0 P40227;P40227-2;Q92526;Q92526-2;Q92526-3 P40227;P40227-2;Q92526 CCT6A;CCT6B T-complex protein 1 subunit zeta;T-complex protein 1 subunit zeta-2 0 13761300.0 4887200.0 5803300.0 3070800.0 False True 6326576.741114402 5480341.2534893025 2511945.909068789 1.0 0.8662411723980703 0.39704661965837773 22.592993649621217 -6.947893195741774 0.5815126109631358 1.0055772760086983 0.2344429891880865 0.9990254172072671 0.008071188480486591 0.08434290744203415 0.03954963811712368 0.008442721681798437 0.039210812580125314 1.1274746973053371e-07 6.947893195741774 -0.7711342868206118 down GGAALCLNAQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAALCLNAQGR 12 0 H0YBR2;H0YBB3;A0A2U3TZN9;Q6NXG1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1 H0YBR2 ESRP1 Epithelial splicing regulatory protein 1 0 114113000.0 24553000.0 46953000.0 42607000.0 False True 33630907.6198761 44878461.20719243 32544104.11870944 1.0 1.334440976569688 0.9676843838575337 25.00328437858079 -6.666794291786465 1.949124249381258 1.2140660751362335 0.9691994620775994 0.2647193531643164 0.1421706523997622 0.4685469376776534 3.428728198636758 0.058791640831237287 0.15771385550968584 2.1538016642857687e-07 6.666794291786465 -0.2448666130586341 GGAALCLNAQGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGAALCLNAQGR 12 0 H0YBR2;H0YBB3;A0A2U3TZN9;Q6NXG1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1 H0YBR2 ESRP1 Epithelial splicing regulatory protein 1 0 38374900.0 16067000.0 16458000.0 5849900.0 False True 13360422.388785807 16369337.487342766 7073087.043118445 1.0 1.2252110757428236 0.5294059452083869 23.671462283443695 -6.819574137627665 1.3737151586857357 1.121443018207925 0.5143554356019856 0.8833875471265981 0.09899312361971609 0.19404594729951183 0.7196447151916668 0.05662970000993448 0.13053744520344915 1.5150461508265415e-07 6.819574137627665 -0.6070875826059393 GGAALCLNAQGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGAALCLNAQGR 12 0 H0YBR2;H0YBB3;A0A2U3TZN9;Q6NXG1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1 H0YBR2 ESRP1 Epithelial splicing regulatory protein 1 0 347294000.0 118500000.0 154360000.0 74434000.0 False True 153400585.98421502 145769730.30665478 60887775.7573357 1.0 0.9502553681356507 0.3969200988815067 27.19272875298868 -6.9245174108852 0.7904974068316684 1.0103383890741173 0.29770812887762893 0.9953465986365059 0.018645105955083084 0.09558618458308506 0.09237012299912939 0.01646180902323483 0.05165850734587811 1.1898236281214205e-07 6.9245174108852 -0.7126302601964885 down GGAAVDPDSGLEHSAHVLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGAAVDPDSGLEHSAHVLEK 20 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 47015300.0 1781200.0 19442900.0 25791200.0 False True 2335170.449165336 16542095.107830616 23122574.030659832 1.0 7.083891933346145 9.90187848554035 21.1550964285485 -8.677637215576341 0.39907142728144895 2.899442103722163e-17 10.507959137092463 0.9970702429623279 0.20107230253767366 0.27443941775224856 0.1321356873415853 1.158595352534502 0.7028946773514843 2.100693948796307e-09 8.677637215576341 10.507959137092463 GGAAVDPDSGLEHSAHVLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGAAVDPDSGLEHSAHVLEK 20 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 35245500.0 3169600.0 7499500.0 24576400.0 False True 3068982.782951319 10494089.459375858 18139103.563803833 1.0 3.419403170872177 5.9104611679705075 21.549329121606114 -6.970759596776947 0.23934784444764373 0.09826634240727812 9.3035901690745 0.9999877163703816 0.007026277172111734 0.07605697761559098 0.008143041979892207 0.059821537961163074 0.24313560598386164 1.0696468171694393e-07 6.970759596776947 9.205323826667222 GGAAVDPDSGLEHSAHVLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGAAVDPDSGLEHSAHVLEK 20 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 102061000.0 14258800.0 82553000.0 5249200.0 False True 21631642.05791166 67820772.160467 4211693.319193906 1.0 3.135257692360988 0.19470058296630796 24.36663984864637 -6.7119583989822456 1.78821282437798 2.3100777724030483 0.20120155168421727 0.4743911804124141 0.8995157384550027 0.37115992406931647 2.314767690876744 0.4001209960260287 1.0140929342265839 1.941071803729338e-07 6.7119583989822456 -2.108876220718831 GGAAVDPDSGLEHSAHVLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAAVDPDSGLEHSAHVLEK 20 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 71514300.0 1781200.0 43523000.0 26210100.0 False True 2439757.7751200804 41600009.94868557 20019814.19395372 1.0 17.050877088254424 8.205656478733173 21.21830649007139 -9.999011705417386 11.94002679091729 1.0000000374423927 12.628266829813557 0.6973700435787993 3.6110461926127795 0.0 0.0 3.496380181093137 1.165460147197916 1.0022782235899421e-10 9.999011705417386 11.628266792371164 GGAAVDPDSGLEHSAHVLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGAAVDPDSGLEHSAHVLEK 20 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 36221700.0 14258800.0 10251700.0 11711200.0 False True 18458297.68296814 9681183.883031445 9579881.767059542 1.0 0.5244895303625142 0.519001369010269 24.137766170738818 GGAAVDPDSGLEHSAHVLEKGGK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGAAVDPDSGLEHSAHVLEKGGK 23 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 130653000.0 47761000.0 48256000.0 34636000.0 True False 62615133.51818191 41056392.90041477 31052198.971972372 1.0 0.6556944079420193 0.49592162832257747 25.90000805001149 -13.99999999843033 0.10278516458907928 2.687362048553553 0.16985220906642734 0.9997796970995922 0.003121919220618725 12.059839111030927 0.09602926999607368 4.2871859856063725 0.2903833997074992 1.0000000036143002e-14 13.99999999843033 -2.5175098394871256 GGAAVDPDSGLEHSAHVLEKGGK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGAAVDPDSGLEHSAHVLEKGGK 23 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 132081000.0 37721000.0 52852000.0 41508000.0 True False 36523567.50243152 73956079.2195389 30635809.586691733 1.0 2.024886512376299 0.8387956511819987 25.122324354141995 -6.678085056059651 1.9082927242374481 1.649543271685889 0.8433280412382947 0.31559794329501145 0.4345496835224767 0.4427662492076568 3.1155629616149088 0.1828173766462418 0.48342517954571224 2.0985288489861508e-07 6.678085056059651 -0.8062152304475944 GGAAVDPDSGLEHSAHVLEKGGK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAAVDPDSGLEHSAHVLEKGGK 23 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 128568000.0 47761000.0 38916000.0 41891000.0 True False 65419532.39249392 37196562.44199728 31997208.572226584 1.0 0.568584963567626 0.4891078765322674 25.96321811153438 -13.999999999999998 0.2378969637929707 3.82673404339339 0.45325877380450363 0.9995215360731241 0.004909824604584684 13.550162166611925 0.15438450482463514 18.174038664769476 0.03932139807837631 1.0000000000000041e-14 13.999999999999998 -3.3734752695888863 GGAAVDPDSGLEHSAHVLEKGGK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGAAVDPDSGLEHSAHVLEKGGK 23 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 128413000.0 37721000.0 59197000.0 31495000.0 True False 31366682.82363785 58878094.011315435 38080458.883573264 1.0 1.877090234321656 1.2140416344847256 24.90272962957627 -10.270378094788605 4.738800339323077 0.9998488832889455 1.5455659343931887 0.4744305276546599 0.2706884583238125 0.000544217859058412 8.379183735372976e-05 0.26218321458152527 0.08736432411578625 5.365644624047247e-11 10.270378094788605 0.5457170511042432 GGAAVDPDSGLEHSAHVLEKGGK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGAAVDPDSGLEHSAHVLEKGGK 23 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 238077000.0 74968000.0 91538000.0 71571000.0 True False 97047553.84020804 86443829.83163093 58545812.38047491 1.0 0.8907368234542368 0.6032693258489802 26.532188513347517 -6.954358471771319 0.5087519717797907 1.005345373282875 0.47607597407142094 0.9995004109245421 0.0037399015860068324 0.08178140572526828 0.02907411632986399 0.0043169723706344785 0.023723462785614498 1.1108144694531519e-07 6.954358471771319 -0.5292693992114541 GGAEQFMEETER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGAEQFMEETER 12 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 35211600.0 3835600.0 11974000.0 19402000.0 False True 5028508.744003233 10187525.87428643 17394467.157125756 1.0 2.025953695802081 3.459170112385624 22.261699186728 -6.966412918120577 0.33291298578928896 0.8312143008938603 4.701032893193203 0.9999393773533618 0.00785247315796065 0.07748472189244887 0.013186931367852161 0.02070137916093123 0.12471917224228572 1.0804062351321574e-07 6.966412918120577 3.8698185922993424 GGAEQFMEETER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGAEQFMEETER 12 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 25848300.0 5829500.0 3144800.0 16874000.0 False True 5644445.7134069735 4400535.03991535 12454193.19085083 1.0 0.7796221743196106 2.206451053514254 22.42840048410784 -6.867466561213936 1.1473428950210574 0.8770697731502641 2.286111039113059 0.9620923978599577 0.1221066485253886 0.13931094569285934 0.3443262269816465 0.08271203883582741 0.19501792345611557 1.3568549982109981e-07 6.867466561213936 1.4090412659627949 up GGAEQFMEETER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGAEQFMEETER 12 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 75889000.0 3678700.0 68385000.0 3825300.0 False True 5580856.8489942765 56181162.45555631 3069227.778311452 1.0 10.06676286020142 0.5499563707434202 22.412055210535094 -6.65715737531674 1.9828782966074034 6.849882517876183 0.589809481577484 0.22353874415829023 3.8630870540894926 0.4912871178200735 3.710210595087845 1.5756141514766928 4.281453031111752 2.2021283330804766e-07 6.65715737531674 -6.2600730362986985 GGAEQFMEETER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAEQFMEETER 12 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 33104600.0 3835600.0 10722000.0 18547000.0 False True 5253724.973192553 10248266.587087458 14166580.58745522 1.0 1.9506667439540237 2.6964830971817233 22.32490924825089 -7.018462959103503 0.14072245002483472 4.794336521812064e-13 4.633431672444402 0.999999043556875 0.0006789543979593929 0.07211142607152062 0.00424241991948001 0.04222665272040869 0.09496447992525604 9.583784527426765e-08 7.018462959103503 4.633431672443923 GGAEQFMEETER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGAEQFMEETER 12 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 10081500.0 5829500.0 2630000.0 1622000.0 False True 4847487.540637755 2615831.6679858747 1961152.7007193451 1.0 0.5396262798112784 0.40457096264373854 22.208805759542116 -13.999999999999998 0.17192051894347124 3.3335812042370048 0.28784018162925734 0.9995101454950075 0.005641387237741249 12.110793887258739 0.1313370738547368 9.426983219945665 0.10821304477511094 1.0000000000000041e-14 13.999999999999998 -3.0457410226077473 GGAEQFMEETER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGAEQFMEETER 12 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 11707200.0 3678700.0 4416200.0 3612300.0 False True 4762149.668017987 4170434.587848206 2954898.46532799 1.0 0.8757462235713281 0.6204967653941508 22.183181532627543 -6.959517833571462 0.44217596369270984 1.0089223171305475 0.47733281188706206 0.9997518972532268 0.00248835171765179 0.07987379877356905 0.021771062422319794 0.0033746273960568824 0.021140508571900838 1.0976962143019326e-07 6.959517833571462 -0.5315895052434854 GGAEVQIFAPDVPQMHVIDHTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGAEVQIFAPDVPQMHVIDHTK 22 0 A0A096LPI6;P0DPI2;A0A0B4J2D5;P0DPI2-2;A0A0B4J2D5-2;A0A096LP73;A0A2R8YDR7;F2Z2Q0;A0A096LP12;A0A096LNJ1;A0A2R8Y6K9 A0A096LPI6 C21orf33 0 8232000.0 2637600.0 1878100.0 3716300.0 False True 2553870.831749244 2628035.124162116 2742889.543389768 1.0 1.0290399543668676 1.0740126357569375 21.284254128387015 -6.96472146235082 0.3628029415128821 0.9962467000037808 1.1083537835664874 0.9999072497412013 0.0002931786074349905 0.07805564303652257 0.015194138974377706 0.0006000770342566039 0.003834891760264382 1.084622320721543e-07 6.96472146235082 0.1121070835627066 GGAEVQIFAPDVPQMHVIDHTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGAEVQIFAPDVPQMHVIDHTK 22 0 A0A096LPI6;P0DPI2;A0A0B4J2D5;P0DPI2-2;A0A0B4J2D5-2;A0A096LP73;A0A2R8YDR7;F2Z2Q0;A0A096LP12;A0A096LNJ1;A0A2R8Y6K9 A0A096LPI6 C21orf33 0 45565800.0 4602800.0 27623000.0 13340000.0 False True 6982784.109753691 22693459.83051592 10703343.152870301 1.0 3.249915717545563 1.5328188562953937 22.735370938208074 -6.5776350063165685 2.276081697519009 2.5343030620621447 1.536890579560573 0.0 0.9780132112293736 0.7065028544415694 6.88083365331548 0.3613280238994027 1.09399512568503 2.6446304477655716e-07 6.5776350063165685 -0.9974124825015718 GGAEVQIFAPDVPQMHVIDHTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAEVQIFAPDVPQMHVIDHTK 22 0 A0A096LPI6;P0DPI2;A0A0B4J2D5;P0DPI2-2;A0A0B4J2D5-2;A0A096LP73;A0A2R8YDR7;F2Z2Q0;A0A096LP12;A0A096LNJ1;A0A2R8Y6K9 A0A096LPI6 C21orf33 0 9555200.0 2356300.0 2331500.0 4867400.0 False True 3227487.7866132106 2228486.620760527 3717820.3672496616 1.0 0.6904709694034216 1.1519239151485636 21.6219802054528 -6.725957472626827 1.7377804956832226 0.8128917612158307 1.1514612374484128 0.5404604374778132 0.1301657302861102 0.3438951410712618 2.0325840527829415 0.059402015666343365 0.14809215301847023 1.8795008539581344e-07 6.725957472626827 0.33856947623258205 GGAGATFECNICLETAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGAGATFECNICLETAR 17 0 Q99942;A0A140TA09 Q99942 RNF5 E3 ubiquitin-protein ligase RNF5 0 23336500.0 10134000.0 9434900.0 3767600.0 False True 13285772.137795597 8027249.6969521595 3377764.8933711518 1.0 0.6041989591343433 0.25423926124414153 23.6633787405155 -7.685937107233282 0.29774117967868585 1.10216631649491 1.4814597975671587e-20 0.9995345829258911 0.006572312444413248 0.12529311657580647 0.04080258844863541 0.03407639411432877 0.07705064358930014 2.0609283469509744e-08 7.685937107233282 -1.10216631649491 down GGAGATFECNICLETAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGAGATFECNICLETAR 17 0 Q99942;A0A140TA09 Q99942 RNF5 E3 ubiquitin-protein ligase RNF5 0 92315000.0 26145000.0 33039000.0 33131000.0 False True 39663876.45552931 27142932.31511477 26582643.32816686 1.0 0.6843237409118879 0.6701978148295974 25.24132234707009 GGAGATFECNICLETAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAGATFECNICLETAR 17 0 Q99942;A0A140TA09 Q99942 RNF5 E3 ubiquitin-protein ligase RNF5 0 20008200.0 10134000.0 3940700.0 5933500.0 False True 13880813.661052603 3766586.8438477465 4532129.5042683715 1.0 0.2713520212735224 0.32650315859975987 23.726588802038393 -10.52000095401211 9.58386383013311 1.0000176001910024 0.29892758993664126 0.9953800908517798 0.02251535753057418 8.467431234523727e-06 4.2405580803040127e-07 0.02180094526977879 0.007266800395818294 3.0199450864992895e-11 10.52000095401211 -0.7010900102543611 GGAGATFECNICLETAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGAGATFECNICLETAR 17 0 Q99942;A0A140TA09 Q99942 RNF5 E3 ubiquitin-protein ligase RNF5 0 85442000.0 26145000.0 27786000.0 31511000.0 False True 33845217.89499837 26239684.674142975 25776321.330163717 1.0 0.7752848498582324 0.7615941906514636 25.012448669162538 -13.999999999999998 0.39807424370524325 4.7414143646141325 0.7607539161165258 0.9998350252853239 0.0014038857063629149 26.487154120342296 0.20770908417516898 85.53412892573115 0.0035217670231766423 1.0000000000000041e-14 13.999999999999998 -3.9806604484976065 GGAGFPTGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGAGFPTGLK 10 0 G3V0I5;P49821-2;P49821;E9PMX3;E9PPR0;E9PQP1 G3V0I5 NDUFV1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0 89448000.0 25314000.0 36458000.0 27676000.0 False True 33186899.141124748 31018608.51217091 24812353.006938078 1.0 0.934664259540087 0.7476550581428366 24.984110499933468 -6.95250200761987 0.5306638742126476 1.0029354312671652 0.6708847319465978 0.9993832928275111 0.002655616491587453 0.08249632140158578 0.03192258126821215 0.0029598427267095327 0.015466004215065972 1.1155729943622653e-07 6.95250200761987 -0.3320506993205674 GGAGFPTGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGAGFPTGLK 10 0 G3V0I5;P49821-2;P49821;E9PMX3;E9PPR0;E9PQP1 G3V0I5 NDUFV1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0 44369000.0 18604000.0 12013000.0 13752000.0 False True 18013426.20331473 16809853.546967413 10149938.648843214 1.0 0.9331846899771993 0.5634651917010368 24.1025692761286 -6.937572235966655 0.6817809025458552 1.004375801412997 0.47050478270452334 0.9978282116864953 0.008946905649120119 0.0888920857740145 0.059786864615733515 0.008556521674749752 0.0321762325575082 1.1545899263984472e-07 6.937572235966655 -0.5338710187084738 GGAGFPTGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGAGFPTGLK 10 0 G3V0I5;P49821-2;P49821;E9PMX3;E9PPR0;E9PQP1 G3V0I5 NDUFV1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0 252709000.0 120660000.0 92619000.0 39430000.0 False True 183050041.4275831 76090415.81445014 31636643.21721708 1.0 0.41568095380383985 0.17283057119510642 27.447662859249753 -9.977938793231882 0.22136636334700294 1.5932633052150333 2.1834466244102857e-20 0.9992750702427983 0.009346828909044126 1.466447555702037 0.10048488186555686 0.6572406613455061 0.1254337988083342 1.0521101412466915e-10 9.977938793231882 -1.5932633052150333 GGAGFPTGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAGFPTGLK 10 0 G3V0I5;P49821-2;P49821;E9PMX3;E9PPR0;E9PQP1 G3V0I5 NDUFV1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0 124162000.0 25314000.0 54423000.0 44425000.0 False True 34673269.885127895 52018411.90720577 33932729.961594716 1.0 1.5002453497908363 0.9786423395893558 25.04732056145636 -8.779704340639107 18.62589060086407 1.0000023210701026 1.2394438446767446 0.2193439430098275 0.21294353721977619 0.0 0.0 0.20618169333176775 0.06872723111058923 1.660717107066949e-09 8.779704340639107 0.23944152360664206 GGAGFPTGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGAGFPTGLK 10 0 G3V0I5;P49821-2;P49821;E9PMX3;E9PPR0;E9PQP1 G3V0I5 NDUFV1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0 49597600.0 18604000.0 27106000.0 3887600.0 False True 15470050.296942225 26959974.59788027 4700479.185768518 1.0 1.74272055231838 0.30384382051411973 23.882974551562878 -6.766350146252044 1.5880960461799356 1.4279521107479665 0.29675649346450356 0.7166407200653624 0.3127465125090352 0.2723086853818957 1.3547355304244126 0.1552721127093905 0.37091279127273474 1.7125760008370013e-07 6.766350146252044 -1.131195617283463 GGAGFPTGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGAGFPTGLK 10 0 G3V0I5;P49821-2;P49821;E9PMX3;E9PPR0;E9PQP1 G3V0I5 NDUFV1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0 299427000.0 120660000.0 112980000.0 65787000.0 False True 156196748.56418046 106692563.68259817 53814441.03162324 1.0 0.6830652024664824 0.34452984153835414 27.218789181342203 -7.174536673316562 0.2783479404463193 1.0858941559234103 3.737024732162756e-14 0.9999521348166108 0.001851670228236702 0.0861710823986804 0.013585871212864281 0.00958077638845016 0.03736340273677594 6.690573201640335e-08 7.174536673316562 -1.085894155923373 down GGAGGMQQGSSPAPDSCQPGPGPSPGLTSIVSGTSEDLRPPR ddPTM_RPMI8226_Bortezomib_1h_R1 2 GGAGGMQQGSSPAPDSCQPGPGPSPGLTSIVSGTSEDLRPPR 42 1 Q96IQ9;Q96IQ9-2 Q96IQ9 ZNF414 Zinc finger protein 414 0 49479500.0 9082600.0 26950300.0 13446600.0 False True 11907376.556023512 22929420.29144662 12055274.820895113 1.0 1.925648372969901 1.0124207262763336 23.505352256546825 -6.643055576246388 2.033339184060718 1.6039226304088674 1.0162388857637166 0.1663784154744763 0.3957586276038963 0.5257698226741709 4.158213254176606 0.15829171022773675 0.4382740557335427 2.274806307373796e-07 6.643055576246388 -0.5876837446451508 GGAGGMQQGSSPAPDSCQPGPGPSPGLTSIVSGTSEDLRPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGAGGMQQGSSPAPDSCQPGPGPSPGLTSIVSGTSEDLRPPR 42 1 Q96IQ9;Q96IQ9-2 Q96IQ9 ZNF414 Zinc finger protein 414 0 26296900.0 12044000.0 8447900.0 5805000.0 False True 11661669.81255228 11821190.525216512 4284496.353732906 1.0 1.0136790627095726 0.36739990263840255 23.475271044328668 -6.902067754508238 0.9481274304096892 1.0253667896265153 0.29664579113218537 0.9875665788630229 0.03361732273289256 0.10989845933739646 0.16897032863514475 0.026486244992747047 0.06965393930637537 1.2529456869837489e-07 6.902067754508238 -0.7287209984943299 down GGAGGMQQGSSPAPDSCQPGPGPSPGLTSIVSGTSEDLRPPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGAGGMQQGSSPAPDSCQPGPGPSPGLTSIVSGTSEDLRPPR 42 1 Q96IQ9;Q96IQ9-2 Q96IQ9 ZNF414 Zinc finger protein 414 0 112973000.0 44203000.0 43010000.0 25760000.0 False True 67059182.67216522 35334529.46133618 20668524.708990887 1.0 0.5269155998228824 0.30821319147347637 25.998931563656985 -11.209554763078001 0.14334642582338739 2.070931546142787 1.1299724495508404e-11 0.9996800944038352 0.0051639307124607976 3.6270810512021803 0.08679588888797687 1.4702991906546408 0.2185328662538215 6.17227456668652e-12 11.209554763078001 -2.070931546131487 GGAGGMQQGSSPAPDSCQPGPGPSPGLTSIVSGTSEDLRPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GGAGGMQQGSSPAPDSCQPGPGPSPGLTSIVSGTSEDLRPPR 42 1 Q96IQ9;Q96IQ9-2 Q96IQ9 ZNF414 Zinc finger protein 414 0 64251900.0 9082600.0 34304700.0 20864600.0 False True 12440682.668035952 32789004.923527177 15936811.199925479 1.0 2.6356274650242866 1.2810238493480897 23.568562318069716 -6.599724979862948 2.1921663586942053 2.1001994611900097 1.2854376131127532 0.01967635504834475 0.707020649141034 0.6414289191904559 5.825312145455187 0.2677912721386262 0.7863158277961441 2.5134776056064503e-07 6.599724979862948 -0.8147618480772565 GGAGGMQQGSSPAPDSCQPGPGPSPGLTSIVSGTSEDLRPPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGAGGMQQGSSPAPDSCQPGPGPSPGLTSIVSGTSEDLRPPR 42 1 Q96IQ9;Q96IQ9-2 Q96IQ9 ZNF414 Zinc finger protein 414 0 22722100.0 12044000.0 7121200.0 3556900.0 False True 10015119.639667394 7082836.6821524715 4300631.344752557 1.0 0.7072143855475396 0.42941387616767224 23.255676319762944 -7.0060922382191855 0.21512555354907129 1.1383033607163422 2.147897272970923e-10 0.9999930669918772 0.0006133906002964233 0.07276548673605465 0.0069942188014950925 0.008020817913094096 0.027651010927635816 9.860700355756096e-08 7.0060922382191855 -1.1383033605015525 down GGAGGMQQGSSPAPDSCQPGPGPSPGLTSIVSGTSEDLRPPR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GGAGGMQQGSSPAPDSCQPGPGPSPGLTSIVSGTSEDLRPPR 42 1 Q96IQ9;Q96IQ9-2 Q96IQ9 ZNF414 Zinc finger protein 414 0 144283000.0 74031500.0 36383600.0 33867900.0 False True 95835236.1290331 34358820.676245145 27704289.713999886 1.0 0.35851970594598664 0.2890825006858508 26.514052859234763 -13.999999999999998 0.31399828697828625 7.347973636160492 0.27435478935396573 0.999680748205307 0.005718014044665897 17.55940602492141 0.17844890023661858 72.98800415950656 0.023675041113651058 1.0000000000000041e-14 13.999999999999998 -7.073618846806526 GGAGGTDGQGGTFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGAGGTDGQGGTFR 14 0 Q9UDY4;C9JUL4 Q9UDY4 DNAJB4 DnaJ homolog subfamily B member 4 0 152029000.0 45756000.0 58619000.0 47654000.0 False True 59986559.10173436 49873273.69507241 42723221.20944603 1.0 0.8314074759729042 0.7122132332509599 25.838135943440232 -6.974857086807119 0.08108602136251962 1.4100726208098966 0.13055544623629983 0.9999998913795566 3.848036191592479e-05 0.07475579858586462 0.0023534867691813385 0.014100329038995794 0.022881027120761867 1.0596023509335187e-07 6.974857086807119 -1.2795171745735967 GGAGGTDGQGGTFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGAGGTDGQGGTFR 14 0 Q9UDY4;C9JUL4 Q9UDY4 DNAJB4 DnaJ homolog subfamily B member 4 0 101882000.0 31959000.0 35166000.0 34757000.0 False True 30944479.038472164 49207967.18826732 25653099.012350455 1.0 1.5902018297703062 0.8290040682364332 24.883178698067276 -6.699762085007738 1.832219423666296 1.3665869867362601 0.8313152211438462 0.41624759346656237 0.24914318951616465 0.39600214269079065 2.584480798683048 0.10850048336284225 0.2790646478179968 1.9963556580517235e-07 6.699762085007738 -0.535271765592414 GGAGGTDGQGGTFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGAGGTDGQGGTFR 14 0 Q9UDY4;C9JUL4 Q9UDY4 DNAJB4 DnaJ homolog subfamily B member 4 0 261617000.0 111560000.0 105490000.0 44567000.0 False True 169244676.12847003 86664485.3028681 35758312.91559001 1.0 0.5120662421137722 0.2112817592468707 27.33453521125156 -8.486016733001513 0.2610727904518755 1.2197419688529147 6.691891155553994e-22 0.9992499990763405 0.008900505095949432 0.15895569940231336 0.06877030439041402 0.12882616666761657 0.10683180441516484 3.265752492599527e-09 8.486016733001513 -1.2197419688529147 down GGAGGTDGQGGTFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAGGTDGQGGTFR 14 0 Q9UDY4;C9JUL4 Q9UDY4 DNAJB4 DnaJ homolog subfamily B member 4 0 180404000.0 45756000.0 62136000.0 72512000.0 False True 62673229.70940632 59390626.063725576 55386159.03151733 1.0 0.9476235122890424 0.8837291342463669 25.901346004963123 -6.968464347585471 0.29255335937865273 1.012109330169709 0.8172621924892902 0.9999677871041259 0.0002697862907933039 0.07680423937819905 0.010804631460243323 0.0011011984676924116 0.005777323282655319 1.0753148722902501e-07 6.968464347585471 -0.19484713768041884 GGAGGTDGQGGTFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGAGGTDGQGGTFR 14 0 Q9UDY4;C9JUL4 Q9UDY4 DNAJB4 DnaJ homolog subfamily B member 4 0 104950200.0 31959000.0 64872000.0 8119200.0 False True 26575324.523757104 64522521.65991614 9816887.18106075 1.0 2.4279109593651813 0.3693985814654835 24.663583973501552 -6.720127718344989 1.7585898274758363 1.8686218158775485 0.3725380228916654 0.5131370011101508 0.6008654300858788 0.35512233799714077 2.146384977540422 0.27126957326621587 0.6809541855291721 1.9049004379718866e-07 6.720127718344989 -1.4960837929858832 GGAGGTDGQGGTFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGAGGTDGQGGTFR 14 0 Q9UDY4;C9JUL4 Q9UDY4 DNAJB4 DnaJ homolog subfamily B member 4 0 235558000.0 111560000.0 76509000.0 47489000.0 False True 144416619.1763633 72251206.89318383 38846489.278288364 1.0 0.5002970385627834 0.26898905056660116 27.10566153334401 -10.440134757997972 0.16714931506045833 1.8054798320277143 9.059705485065532e-15 0.9995971093182324 0.006123309422721264 2.184210846945724 0.08549009532092904 0.9088497383239481 0.17881480224792798 3.62965412119399e-11 10.440134757997972 -1.8054798320277052 GGAGHWNGLYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGAGHWNGLYR 11 0 Q14573 Q14573 ITPR3 Inositol 1,4,5-trisphosphate receptor type 3 0 90914200.0 24101200.0 35282900.0 31530100.0 False True 31596906.59635279 30018828.851667017 28267667.71007578 1.0 0.9500559417146257 0.8946340245009522 24.91327998664699 -6.969784900594094 0.26332873814271596 1.0149408230408883 0.8280978006879491 0.9999806185872311 0.00018937004786901822 0.07637303385582393 0.009282328037590517 0.0011325432496546283 0.0052034580846358446 1.072050143787013e-07 6.969784900594094 -0.18684302235293915 GGAGHWNGLYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGAGHWNGLYR 11 0 Q14573 Q14573 ITPR3 Inositol 1,4,5-trisphosphate receptor type 3 0 37915200.0 13135300.0 13090000.0 11689900.0 False True 12718327.091399703 18316905.26344823 8627964.500517195 1.0 1.4401976873070326 0.6783883162079969 23.60040558202999 -6.750054407894263 1.649937387371316 1.2588258906621166 0.676894518877104 0.6491013704467096 0.18497301951180484 0.2999423624096913 1.6065936401181982 0.08856647803989415 0.2149783712917708 1.778056643271486e-07 6.750054407894263 -0.5819313717850126 GGAGHWNGLYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGAGHWNGLYR 11 0 Q14573 Q14573 ITPR3 Inositol 1,4,5-trisphosphate receptor type 3 0 79356000.0 25762200.0 22979000.0 30614800.0 False True 39083140.86910061 18878217.91425354 24563771.36105646 1.0 0.4830271440435532 0.6285004432813316 25.220043076609794 -10.566259941801281 9.65725727858431 1.000028765678197 0.5557637936624692 0.9255602928699529 0.05938922572196102 3.678461238905094e-05 1.6521470880353672e-06 0.05750707105586564 0.01916779018044236 2.714813862877284e-11 10.566259941801281 -0.4442649720157278 GGAGHWNGLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAGHWNGLYR 11 0 Q14573 Q14573 ITPR3 Inositol 1,4,5-trisphosphate receptor type 3 0 62041600.0 24101200.0 21767500.0 16172900.0 False True 33012064.95044019 20805739.874503445 12353194.111330919 1.0 0.6302465448840702 0.37420240538955435 24.976490048169882 -8.100260248043712 0.1830028284152206 1.2942543484264797 1.6674762449654762e-17 0.9998703893867221 0.0029245188398133197 0.09212373418697989 0.03447348211528821 0.09552999473677333 0.11243440958700286 7.938523814688519e-09 8.100260248043712 -1.2942543484264797 down GGAGHWNGLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGAGHWNGLYR 11 0 Q14573 Q14573 ITPR3 Inositol 1,4,5-trisphosphate receptor type 3 0 36681160.0 13135300.0 19466000.0 4079860.0 False True 10922583.942454595 19361132.79430152 4932939.862858711 1.0 1.7725780727623832 0.4516275534111526 23.380810857464265 -6.7481858681087905 1.6565936344131236 1.4552761018443856 0.44936789073006517 0.6411014394496531 0.3246175979681715 0.3032262514008119 1.636679869527719 0.15483462739900863 0.37661026695639643 1.785723162602409e-07 6.7481858681087905 -1.0059082111143205 GGAGHWNGLYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGAGHWNGLYR 11 0 Q14573 Q14573 ITPR3 Inositol 1,4,5-trisphosphate receptor type 3 0 73212500.0 25762200.0 22530300.0 24920000.0 False True 33349675.74888222 21276468.99927457 20384815.700792734 1.0 0.6379812853199238 0.6112447945307525 24.991169398702244 -13.999999999999998 0.3697311033255602 6.034120537713327 0.6084613178928822 0.9997904398300547 0.0025665562901736705 22.788691956220852 0.19734466441919185 90.91520917417098 0.007478695607256181 1.0000000000000041e-14 13.999999999999998 -5.425659219820445 GGAGNISLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGAGNISLK 9 0 Q14181;A0A3B3ITS5 Q14181 POLA2 DNA polymerase alpha subunit B 0 20710900.0 4688500.0 9626300.0 6396100.0 False True 6146668.903498583 8190093.563023507 5734292.927723538 1.0 1.3324442379451804 0.9329106574228642 22.551373344268324 -6.685886497385611 1.881340190492969 1.2092253023800643 0.9343680161761949 0.3510891681599133 0.14072098653010603 0.4255807264031211 2.9172309570970176 0.05991470958615813 0.15681814434495717 2.0611685280992368e-07 6.685886497385611 -0.2748572862038694 GGAGNISLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGAGNISLK 9 0 Q14181;A0A3B3ITS5 Q14181 POLA2 DNA polymerase alpha subunit B 0 13843400.0 4079500.0 3532300.0 6231600.0 False True 3949998.505505404 4942765.810701152 4599357.016007234 1.0 1.251333590079099 1.164394621819925 21.913420676765725 -10.068577137961464 4.239854367169798 0.9999771415805663 1.2078641059918713 0.8840175859147628 0.03549268531170918 5047208.486094454 3999191.0428093597 951.1397784067416 0.012150090436175223 8.539311614958087e-11 10.068577137961464 0.20788696441130505 GGAGNISLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGAGNISLK 9 0 Q14181;A0A3B3ITS5 Q14181 POLA2 DNA polymerase alpha subunit B 0 83266000.0 35899000.0 34175000.0 13192000.0 False True 54461407.56844691 28076204.239506297 10584595.417741003 1.0 0.5155247631861188 0.19435038296500726 25.69873093388256 -8.293925626353172 0.2883335041123604 1.1648280680082517 8.732184431808338e-16 0.9990672384055413 0.010113686737550028 0.10286094229543824 0.06899229078736045 0.0935584418759992 0.09808654861638581 5.082464731556692e-09 8.293925626353172 -1.1648280680082508 down GGAGNISLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAGNISLK 9 0 Q14181;A0A3B3ITS5 Q14181 POLA2 DNA polymerase alpha subunit B 0 34766500.0 4688500.0 18836000.0 11242000.0 False True 6421965.151948402 18003763.23767757 8586871.136257702 1.0 2.8034663551880676 1.3371095814265632 22.614583405791215 -6.594811823022213 2.2099643357673475 2.2168962293283996 1.3415682568444833 0.006011585420594656 0.7805392742168268 0.6556065744663795 6.043223165072267 0.29399649322534666 0.8693290965708297 2.5420739310759035e-07 6.594811823022213 -0.8753279724839163 GGAGNISLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGAGNISLK 9 0 Q14181;A0A3B3ITS5 Q14181 POLA2 DNA polymerase alpha subunit B 0 15592100.0 4079500.0 10417000.0 1095600.0 False True 3392285.002492791 10360881.553387385 1324684.8945179498 1.0 3.054248550983712 0.39049929282018364 21.6938259522 -6.700763998479506 1.828385334307548 2.274656891336341 0.3983676833299145 0.4211303559038264 0.8670026769127683 0.3939162481620176 2.5607497088094866 0.3782446877641984 0.9717424302217215 1.991755391893429e-07 6.700763998479506 -1.8762892080064264 GGAGNISLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGAGNISLK 9 0 Q14181;A0A3B3ITS5 Q14181 POLA2 DNA polymerase alpha subunit B 0 82218000.0 35899000.0 26453000.0 19866000.0 False True 46471963.17508299 24980867.29594413 16250591.8423735 1.0 0.5375470625553042 0.34968593388554386 25.469857255975008 -13.999999999999998 0.1239914519436476 3.1992465104094907 0.06536126510171789 0.9996736030160435 0.0049369244381099525 11.950216073479151 0.10886363784370405 6.4443263058576115 0.2524336253526171 1.0000000000000041e-14 13.999999999999998 -3.133885245307773 GGAGNTSTSCGDSNSICPAPSTMSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGAGNTSTSCGDSNSICPAPSTMSK 25 0 P49247 P49247 RPIA Ribose-5-phosphate isomerase 0 6555400.0 1554100.0 3595000.0 1406300.0 False True 2037440.1499258073 3058640.0132002416 1260789.5661821452 1.0 1.5012171097696396 0.6188106022294969 20.958326249932465 -6.75263151902674 1.6403004735887123 1.2937828342483502 0.6167174606629161 0.660177938622847 0.21064637508449874 0.29545708848416213 1.5648735821812554 0.10141691950536028 0.24551766721163948 1.7675368668588643e-07 6.75263151902674 -0.6770653735854341 GGAGNTSTSCGDSNSICPAPSTMSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGAGNTSTSCGDSNSICPAPSTMSK 25 0 P49247 P49247 RPIA Ribose-5-phosphate isomerase 0 29027400.0 11310000.0 13667000.0 4050400.0 False True 17158096.871755045 11228017.069241615 3249836.664646614 1.0 0.6543859236349642 0.18940542700842083 24.032386206213065 -7.399009736107863 0.42772648847096256 1.026851442697354 4.800427757535979e-13 0.998942874212502 0.010798297695547443 0.11156401064055989 0.04467773801496204 0.015659952598600587 0.060578225722008834 3.990159570356302e-08 7.399009736107863 -1.026851442696874 down GGAGNTSTSCGDSNSICPAPSTMSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAGNTSTSCGDSNSICPAPSTMSK 25 0 P49247 P49247 RPIA Ribose-5-phosphate isomerase 0 10005900.0 1554100.0 4422200.0 4029600.0 False True 2128692.7679733415 4226812.581740171 3077891.472217041 1.0 1.9856376858762856 1.4459068582017125 21.021536311455357 -10.18755150207306 5.741522907540745 0.9999845121446799 1.7157722720390147 0.7010420822619592 0.22034418770887085 4.369397742890821e-05 6.182963167219344e-06 0.2133519526013564 0.07111578078582644 6.493046273345084e-11 10.18755150207306 0.7157877598943349 GGAGNTSTSCGDSNSICPAPSTMSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGAGNTSTSCGDSNSICPAPSTMSK 25 0 P49247 P49247 RPIA Ribose-5-phosphate isomerase 0 30439000.0 11310000.0 12140000.0 6989000.0 False True 14641017.953430137 11464398.328082323 5717073.713195837 1.0 0.7830328713855865 0.3904833483150279 23.803512528305514 -6.961956651624574 0.40691997670549246 1.0199990244473505 0.13902209258973652 0.9998360242313135 0.0032301601398231484 0.0790094343946437 0.018602240695585432 0.0050514553719148165 0.03280838168750062 1.0915492821726885e-07 6.961956651624574 -0.8809769318576139 down GGAGQWNSLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGAGQWNSLFR 11 0 Q14571 Q14571 ITPR2 Inositol 1,4,5-trisphosphate receptor type 2 0 264866000.0 70038000.0 112170000.0 82658000.0 False True 91820496.24895678 95434673.23523545 74105343.07152356 1.0 1.0393613314447725 0.8070675513514828 26.452312893408127 -6.863298525134886 1.1690636792247209 1.021570481195929 0.7950948898046808 0.9575190586733318 0.020921466221229788 0.1434363884178296 0.3706665929980954 0.01393885335687996 0.03266558736091818 1.369939773897137e-07 6.863298525134886 -0.22647559139124818 GGAGQWNSLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGAGQWNSLFR 11 0 Q14571 Q14571 ITPR2 Inositol 1,4,5-trisphosphate receptor type 2 0 127965000.0 50771000.0 42587000.0 34607000.0 False True 49159302.395640306 59592211.18827109 25542388.512254044 1.0 1.2122265427744563 0.5195840312518201 25.55096110723108 -6.824458194360533 1.3524188584163626 1.1139039712474867 0.5029605088640868 0.8943399338987725 0.09418423625996998 0.187753190474949 0.673515509270385 0.05470712921614611 0.12597016547041248 1.498103455104217e-07 6.824458194360533 -0.6109434623833999 GGAGQWNSLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGAGQWNSLFR 11 0 Q14571 Q14571 ITPR2 Inositol 1,4,5-trisphosphate receptor type 2 0 363350000.0 120380000.0 105110000.0 137860000.0 False True 182625260.95684114 86352299.27182168 110611910.57381548 1.0 0.472838745414463 0.6056769473964273 27.444311093624574 -10.183903124728538 8.0175599942162 1.000000131932652 0.5392578464055117 0.9413150992110837 0.05423096886743026 1.2792438561444876e-07 1.2979644040677624e-08 0.05250892468418103 0.017502969939354185 6.54782215827807e-11 10.183903124728538 -0.46074228552714025 GGAGQWNSLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAGQWNSLFR 11 0 Q14571 Q14571 ITPR2 Inositol 1,4,5-trisphosphate receptor type 2 0 191592000.0 70038000.0 60802000.0 60752000.0 False True 95932941.30578272 58115566.5946736 46403628.826714836 1.0 0.6057936492266235 0.48370901793582016 26.51552295493102 -13.999999999999998 0.1641412612270862 2.9593652613732218 0.3690136001402917 0.9995260932977325 0.0047961840336005306 12.039880338345466 0.1281592953415435 7.509233978676733 0.10510524291299439 1.0000000000000041e-14 13.999999999999998 -2.59035166123293 GGAGQWNSLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGAGQWNSLFR 11 0 Q14571 Q14571 ITPR2 Inositol 1,4,5-trisphosphate receptor type 2 0 120936000.0 50771000.0 45699000.0 24466000.0 False True 42218336.03666167 45452810.41645874 29581727.481997255 1.0 1.0766130237105582 0.7006843532703183 25.331366382665355 -6.8536244023340664 1.2174500999009323 1.0410480050317261 0.6845700047185901 0.9454173061880834 0.037894864724942225 0.1535158070431343 0.4360393256425631 0.02433153325027814 0.056451716362107156 1.4007982730586384e-07 6.8536244023340664 -0.35647800031313603 GGAGQWNSLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGAGQWNSLFR 11 0 Q14571 Q14571 ITPR2 Inositol 1,4,5-trisphosphate receptor type 2 0 355048000.0 120380000.0 76788000.0 157880000.0 False True 155834283.0445553 72514680.2979231 129147459.98560019 1.0 0.4653320109105266 0.8287487031892401 27.215437415717023 -10.120307437598623 5.569108959078929 1.0000044526783194 0.6470403570498267 0.5570725122275053 0.14836424334904064 8.202549459466922e-06 1.2953589911755797e-06 0.143654873537825 0.04788435363859236 7.580407670554758e-11 10.120307437598623 -0.35296409562849274 GGAGSGNCGGGVGISSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGAGSGNCGGGVGISSR 17 0 A0A1B0GWA0 A0A1B0GWA0 0 83629000.0 27755000.0 35873000.0 20001000.0 False True 36387073.77980233 30520888.231858782 17931488.383139502 1.0 0.8387838059349598 0.49279830776315076 25.116922699641904 -6.958642850941095 0.4541575723879969 1.0106951941588689 0.3070754137141937 0.9997165011181962 0.003562702256657807 0.08018954885575125 0.022949970827841698 0.004654046713169482 0.028602019168912415 1.0999099963005093e-07 6.958642850941095 -0.7036197804446751 down GGAGSGNCGGGVGISSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGAGSGNCGGGVGISSR 17 0 A0A1B0GWA0 A0A1B0GWA0 0 29629300.0 13371000.0 9859300.0 6399000.0 False True 12946544.923915375 13796169.905570291 4722909.9341148725 1.0 1.0656256156872754 0.3648007991221291 23.626063797937803 -6.883969701043951 1.0573732482513782 1.0432772234851047 0.31118442344095815 0.9767505136500974 0.04818932213769196 0.12417348924261999 0.25150948361714975 0.03497112769410733 0.08549289273301544 1.306262017530274e-07 6.883969701043951 -0.7320928000441465 down GGAGSGNCGGGVGISSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGAGSGNCGGGVGISSR 17 0 A0A1B0GWA0 A0A1B0GWA0 0 281030000.0 133260000.0 85823000.0 61947000.0 False True 202165162.61097097 70507215.1118404 49703148.29766537 1.0 0.3487604600181206 0.24585417020295322 27.590959170491384 -13.999999999999998 0.25970117366274087 5.75996452590846 0.20813480255448985 0.9995617247812532 0.006990326342059316 14.40391343075458 0.16126413631702738 35.97521349661346 0.045060105052193794 1.0000000000000041e-14 13.999999999999998 -5.55182972335397 GGAGSGNCGGGVGISSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAGSGNCGGGVGISSR 17 0 A0A1B0GWA0 A0A1B0GWA0 0 79091000.0 27755000.0 29637000.0 21699000.0 False True 38016773.550672494 28327539.34354697 16574143.104932912 1.0 0.7451326532428967 0.4359692198192796 25.180132761164796 -6.96854556993059 0.2908383612450925 1.0598059151275538 0.11173294547862468 0.9999687085189078 0.0012900472356128624 0.07677754304748358 0.010710893255699858 0.005377035064151987 0.02800923017610916 1.0751137842437013e-07 6.96854556993059 -0.9480729696489292 down GGAGSGNCGGGVGISSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGAGSGNCGGGVGISSR 17 0 A0A1B0GWA0 A0A1B0GWA0 0 33189900.0 13371000.0 11409000.0 8409900.0 False True 11118578.935735047 11347537.452490812 10168371.207015801 1.0 1.0205924262515145 0.9145387432862231 23.40646907337208 -6.856342529078315 1.2040254980869545 1.0110816077086076 0.9097492377808583 0.9490432377540334 0.010365044025780892 0.1506177885090642 0.41699323006140465 0.006723454985105174 0.0156359906798787 1.3920584500950686e-07 6.856342529078315 -0.1013323699277493 GGAGSGNCGGGVGISSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGAGSGNCGGGVGISSR 17 0 A0A1B0GWA0 A0A1B0GWA0 0 280564000.0 133260000.0 77066000.0 70238000.0 False True 172507696.94731244 72777209.35354139 57455404.70273995 1.0 0.42187804162598674 0.33305994874123246 27.362085492583834 -13.999999999999785 0.263711048748892 5.315286425118839 0.301733163329901 0.9995699955348947 0.006131702392688936 14.584364811244814 0.16251972427086075 33.61371905375694 0.03808555340275407 1.000000000000495e-14 13.999999999999785 -5.013553261788938 GGAGSGTGGGPGLGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGAGSGTGGGPGLGSR 16 0 F8WFE0;Q8WVR3 F8WFE0 C7orf43 Uncharacterized protein C7orf43 0 42135200.0 11726100.0 19184100.0 11225000.0 False True 15373030.655713923 16321907.0590361 10063544.677803159 1.0 1.0617234444250259 0.6546233402626236 23.873898271722958 -6.868253911371919 1.1432329092635238 1.0345687270195727 0.6315535686431808 0.9629123549086434 0.03449935668562128 0.13854328098487037 0.33950616983256604 0.02344289228969957 0.05534231592683407 1.354397328988365e-07 6.868253911371919 -0.4030151583763919 GGAGSGTGGGPGLGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGAGSGTGGGPGLGSR 16 0 F8WFE0;Q8WVR3 F8WFE0 C7orf43 Uncharacterized protein C7orf43 0 25454800.0 8688600.0 7709400.0 9056800.0 False True 8412785.148899198 10787803.623989891 6684552.381823979 1.0 1.2823106061850946 0.7945706758835562 23.004152069603546 -6.74978167044268 1.650839242562736 1.1660440206912972 0.7936274501214771 0.6479878954533955 0.11862672088591265 0.3004094153127965 1.6107520877109205 0.05676918441382365 0.13784176629874584 1.7791736156531937e-07 6.74978167044268 -0.37241657056982014 GGAGSGTGGGPGLGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGAGSGTGGGPGLGSR 16 0 F8WFE0;Q8WVR3 F8WFE0 C7orf43 Uncharacterized protein C7orf43 0 109348600.0 44251000.0 43752600.0 21345000.0 False True 67132002.1814353 35944606.68937589 17126151.394154165 1.0 0.5354317690723668 0.25511158371037285 26.000497334990335 -8.614631146816759 0.2252296640430107 1.2894960403322056 3.97843303169817e-18 0.9995118676864383 0.006786848618327542 0.2152939444735809 0.062093997874928704 0.1628423460491319 0.12011405737548586 2.4286719289268016e-09 8.614631146816759 -1.2894960403322056 down GGAGSGTGGGPGLGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAGSGTGGGPGLGSR 16 0 F8WFE0;Q8WVR3 F8WFE0 C7orf43 Uncharacterized protein C7orf43 0 45162900.0 11726100.0 17423000.0 16013800.0 False True 16061556.055937327 16653194.24984373 12231670.254563559 1.0 1.0368356709552868 0.7615495168690078 23.93710833324585 -6.873170004237402 1.117248872150975 1.0212888578719461 0.744429752432641 0.9677429865425069 0.02191492111781607 0.1338487562334341 0.31035034742531675 0.015192201786524051 0.03617812371429282 1.3391523746554625e-07 6.873170004237402 -0.27685910543930514 GGAGSGTGGGPGLGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGAGSGTGGGPGLGSR 16 0 F8WFE0;Q8WVR3 F8WFE0 C7orf43 Uncharacterized protein C7orf43 0 27737930.0 8688600.0 15811700.0 3237630.0 False True 7224955.8702436285 15726519.233723294 3914603.4638902424 1.0 2.1766941578832077 0.5418169375971899 22.784557345037822 -6.713576192502972 1.7823801073668701 1.7207725980596962 0.5452423686304502 0.4820031701352365 0.4955895729451872 0.3679851633027408 2.2809681251915275 0.22108312772123043 0.5592490643752929 1.933854553951942e-07 6.713576192502972 -1.175530229429246 GGAGSGTGGGPGLGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGAGSGTGGGPGLGSR 16 0 F8WFE0;Q8WVR3 F8WFE0 C7orf43 Uncharacterized protein C7orf43 0 114307500.0 44251000.0 44039500.0 26017000.0 False True 57283791.81761605 41588663.11116815 21282172.956963256 1.0 0.7260110022671143 0.3715217216193169 25.771623657082785 -6.967598042862806 0.3102446798104807 1.0544544611921527 0.03180612659477517 0.9999571206983903 0.001684690979190409 0.07709006453770381 0.011806016575758997 0.0056025408460638245 0.031464423530127204 1.0774619870008552e-07 6.967598042862806 -1.0226483345973776 down GGAGTMGYKDNDGEEEER ddPTM_RPMI8226_Bortezomib_1h_R1 2 GGAGTMGYKDNDGEEEER 18 1 I3L0T0;H7C5B9;Q6ZQX7-4;Q6ZQX7-2;Q6ZQX7-3;Q6ZQX7 I3L0T0 C17orf97;LIAT1 Protein LIAT1 0 24818200.0 7729600.0 11890500.0 5198100.0 False True 10133580.453552868 10116483.748805977 4660250.47569609 1.0 0.9983128663333505 0.4598819239711261 23.272640669537672 -6.907586463954345 0.9120147044963071 1.0179699476433233 0.3937749792180948 0.9899784209675344 0.02544915086034001 0.10603572798387567 0.14758511308193342 0.02059004494693827 0.05593078408114524 1.2371248654686933e-07 6.907586463954345 -0.6241949684252285 down GGAGTMGYKDNDGEEEER ddPTM_RPMI8226_Bortezomib_2h_R1 2 GGAGTMGYKDNDGEEEER 18 1 I3L0T0;H7C5B9;Q6ZQX7-4;Q6ZQX7-2;Q6ZQX7-3;Q6ZQX7 I3L0T0 C17orf97;LIAT1 Protein LIAT1 0 24487400.0 9574500.0 7286300.0 7626600.0 False True 9270562.738316327 10195757.587552538 5628964.666904285 1.0 1.0997992112617145 0.6071869449347569 23.144225484780932 -6.8539650174890925 1.2157924064035623 1.0534953725799479 0.5859336482940783 0.9458819817721057 0.04946624125662077 0.15314710250674599 0.4336306201232275 0.03180157903350125 0.07380268451389663 1.3997000641633673e-07 6.8539650174890925 -0.4675617242858695 GGAGTMGYKDNDGEEEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGAGTMGYKDNDGEEEER 18 1 I3L0T0;H7C5B9;Q6ZQX7-4;Q6ZQX7-2;Q6ZQX7-3;Q6ZQX7 I3L0T0 C17orf97;LIAT1 Protein LIAT1 0 55269400.0 30744000.0 21960000.0 2565400.0 False True 46640895.6874658 18041066.425736867 2058347.5655452374 1.0 0.3868078895102607 0.04413181898002003 25.475092158398688 -8.500410057268908 0.4341313306207491 1.0807610434519561 3.183077186704567e-24 0.9959797190043324 0.025071008347135933 0.19933511509528878 0.13951915428340314 0.09106223971939083 0.07460703881737778 3.159293272814377e-09 8.500410057268908 -1.0807610434519561 GGAGTMGYKDNDGEEEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAGTMGYKDNDGEEEER 18 1 I3L0T0;H7C5B9;Q6ZQX7-4;Q6ZQX7-2;Q6ZQX7-3;Q6ZQX7 I3L0T0 C17orf97;LIAT1 Protein LIAT1 0 16984900.0 5714200.0 4564400.0 6706300.0 False True 7826894.160448661 4362729.715547653 5122410.060583976 1.0 0.5574024160941979 0.6544626713452765 22.900008505419777 -10.29002880184542 7.028397743303874 1.0000040328363933 0.6059325437197515 0.9564809588044405 0.039624683278238995 2.5040707434995933e-06 2.5289767487638563e-07 0.03836682720734016 0.012788811536280267 5.128273728189431e-11 10.29002880184542 -0.3940714891166418 GGAGTMGYKDNDGEEEER ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GGAGTMGYKDNDGEEEER 18 1 I3L0T0;H7C5B9;Q6ZQX7-4;Q6ZQX7-2;Q6ZQX7-3;Q6ZQX7 I3L0T0 C17orf97;LIAT1 Protein LIAT1 0 26719140.0 9574500.0 14033300.0 3111340.0 False True 7961620.972267974 13957699.827508036 3761906.8087892276 1.0 1.753122872355477 0.4725051370685382 22.92463076021521 -6.7473163710860735 1.659711750586361 1.444255669857747 0.47045795049772016 0.6374181033192016 0.31643337332235066 0.30472489992796065 1.6506679994367428 0.15066332442860997 0.36681571014803277 1.789301923972998e-07 6.7473163710860735 -0.9737977193600267 GGAGTMGYKDNDGEEEEREGGAAGPR ddPTM_RPMI8226_Bortezomib_1h_R1 2 GGAGTMGYKDNDGEEEEREGGAAGPR 26 2 I3L0T0;H7C5B9;Q6ZQX7-4;Q6ZQX7-2;Q6ZQX7-3;Q6ZQX7 I3L0T0 C17orf97;LIAT1 Protein LIAT1 0 48182800.0 23175800.0 9879200.0 15127800.0 False True 30383698.23476648 8405261.868819986 13562520.372104269 1.0 0.27663722183767225 0.4463749036509777 24.856794146304217 -10.516731507705646 9.38379386867813 1.0000186322311204 0.3615060627565025 0.9496644933410194 0.06929511842758108 2.7012253134565675e-05 1.3911224549813203e-06 0.06709665761793275 0.02236490330362435 3.0427655621790634e-11 10.516731507705646 -0.6385125694746179 GGAGTMGYKDNDGEEEEREGGAAGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGAGTMGYKDNDGEEEEREGGAAGPR 26 2 I3L0T0;H7C5B9;Q6ZQX7-4;Q6ZQX7-2;Q6ZQX7-3;Q6ZQX7 I3L0T0 C17orf97;LIAT1 Protein LIAT1 0 10765700.0 4525000.0 2750700.0 3490000.0 False True 4381356.35185977 3849068.854710998 2575864.302244247 1.0 0.8785107956528508 0.5879148134460372 22.06294612846192 -6.95640172616881 0.483489465444003 1.0067511485929612 0.44748712912720173 0.9996125739783739 0.003403021392121316 0.08101249911718836 0.026078274924329514 0.00412676080425499 0.023969260783869555 1.1056006206538335e-07 6.95640172616881 -0.5592640194657594 GGAGTMGYKDNDGEEEEREGGAAGPR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GGAGTMGYKDNDGEEEEREGGAAGPR 26 2 I3L0T0;H7C5B9;Q6ZQX7-4;Q6ZQX7-2;Q6ZQX7-3;Q6ZQX7 I3L0T0 C17orf97;LIAT1 Protein LIAT1 0 333725400.0 121029200.0 139567000.0 73129200.0 False True 183610144.81971866 114660178.40805194 58675181.566333055 1.0 0.6244762702008289 0.31956394143659367 27.452070531776332 -7.697916786152993 0.24105069233992185 1.159409690972492 4.2399582217161647e-13 0.9998070383520957 0.0038656702082655587 0.12870335039306843 0.03143319509886498 0.041634197291752995 0.08000862692387967 2.0048561349617152e-08 7.697916786152993 -1.159409690972068 down GGAGTMGYKDNDGEEEEREGGAAGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GGAGTMGYKDNDGEEEEREGGAAGPR 26 2 I3L0T0;H7C5B9;Q6ZQX7-4;Q6ZQX7-2;Q6ZQX7-3;Q6ZQX7 I3L0T0 C17orf97;LIAT1 Protein LIAT1 0 59982600.0 23175800.0 27027000.0 9779800.0 False True 31744519.56244555 25832857.77366277 7470012.661303412 1.0 0.813773782994139 0.23531660785128397 24.92000420782711 -6.950666553952437 0.5514841361013548 1.0079304175629253 0.013915961414328756 0.9992525140969317 0.008901475317707321 0.08321932037821686 0.034864136327969586 0.009643129729254707 0.04800144391220432 1.1202977043649308e-07 6.950666553952437 -0.9940144561485966 down GGAGTMGYKDNDGEEEEREGGAAGPR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GGAGTMGYKDNDGEEEEREGGAAGPR 26 2 I3L0T0;H7C5B9;Q6ZQX7-4;Q6ZQX7-2;Q6ZQX7-3;Q6ZQX7 I3L0T0 C17orf97;LIAT1 Protein LIAT1 0 18200240.0 6112600.0 9921700.0 2165940.0 False True 5082897.734094227 9868249.832796741 2618828.0398249486 1.0 1.9414614161139059 0.515223436871217 22.277219773945017 -6.728680607546852 1.7278405688324276 1.5674061429072825 0.5162484440440288 0.5531589684239036 0.39581316360171903 0.3387515659107422 1.9806200242153196 0.18157337373860297 0.45127104185680045 1.8677527841244774e-07 6.728680607546852 -1.0511576988632538 GGAGTMGYKDNDGEEEEREGGAAGPR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GGAGTMGYKDNDGEEEEREGGAAGPR 26 2 I3L0T0;H7C5B9;Q6ZQX7-4;Q6ZQX7-2;Q6ZQX7-3;Q6ZQX7 I3L0T0 C17orf97;LIAT1 Protein LIAT1 0 222528700.0 121029200.0 60234400.0 41265100.0 False True 156674685.24220058 56882302.68970691 33755275.21568145 1.0 0.3630599455283639 0.2154481763502494 27.22319685386878 -13.999999999999998 0.2054136625323189 4.6159868794319046 0.12453863457842028 0.9994879555506835 0.007703273602905659 12.643199791735709 0.1436831585535726 18.411686809119878 0.09033440571706665 1.0000000000000041e-14 13.999999999999998 -4.491448244853484 GGAGVGSMTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGAGVGSMTK 10 0 P39019 P39019 RPS19 40S ribosomal protein S19 0 334358000.0 88317000.0 156960000.0 89081000.0 False True 115784442.26304471 133542179.82528797 79863752.6452902 1.0 1.1533689433153753 0.6897623815801768 26.786866173239208 -6.817547283087119 1.3824206303468747 1.0828764435123908 0.6801616569736991 0.8786518553351534 0.06717744262633442 0.19669111284586105 0.739259124682391 0.03819245068043045 0.08809159351343236 1.5221334041240896e-07 6.817547283087119 -0.40271478653869164 GGAGVGSMTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGAGVGSMTK 10 0 P39019 P39019 RPS19 40S ribosomal protein S19 0 110158000.0 41742000.0 45740000.0 22676000.0 False True 40416923.05841557 64004220.53094892 16736475.334581813 1.0 1.583599534245644 0.41409573188914395 25.268456157692306 -6.771026162415975 1.5705576380956332 1.3342956314959864 0.4072650578046761 0.734472011995021 0.24602624959751115 0.26476646913366325 1.2890360928314266 0.12346509656812633 0.29361852502693864 1.6942357345979421e-07 6.771026162415975 -0.9270305736913103 down GGAGVGSMTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGAGVGSMTK 10 0 P39019 P39019 RPS19 40S ribosomal protein S19 0 45953200.0 31807000.0 8225600.0 5920600.0 False True 48253544.40317534 6757677.41309386 4750390.8149088295 1.0 0.14004520282761176 0.09844646385388073 25.524131581827007 -13.274472664384007 0.4392005784017913 9.99768273237227 0.09800071875961254 0.9998753735119073 0.004638913655788965 17.22580379140854 0.22315144338462187 146.34840775327055 0.009631538954059504 5.315294542899773e-14 13.274472664384007 -9.899682013612658 GGAGVGSMTK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GGAGVGSMTK 10 0 P39019 P39019 RPS19 40S ribosomal protein S19 0 399319000.0 88317000.0 184324000.0 126678000.0 False True 120970181.57718416 176179956.20204306 96759265.41530438 1.0 1.45639159919449 0.7998604627502177 26.8500762347621 -6.719732966190755 1.760012150436387 1.2777389084385486 0.8008812375519204 0.5113569306148491 0.19205769744186021 0.35584650729504147 2.1540296956518103 0.08664492711008943 0.21760120037883732 1.906632685180175e-07 6.719732966190755 -0.4768576708866282 GGAGVGSMTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGAGVGSMTK 10 0 P39019 P39019 RPS19 40S ribosomal protein S19 0 120115500.0 41742000.0 70763000.0 7610500.0 False True 34710322.48414116 70381785.67364429 9201820.363023799 1.0 2.027690342139607 0.2651032806516859 25.048861433126582 -6.748625863260682 1.6547117706372803 1.6052709048780631 0.26191337664247205 0.6431606477278602 0.43181681333190075 0.30243062083093386 1.628773576256344 0.2061780531728943 0.5013117429495887 1.783914915687518e-07 6.748625863260682 -1.343357528235591 GGAGVGSMTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGAGVGSMTK 10 0 P39019 P39019 RPS19 40S ribosomal protein S19 0 52844800.0 31807000.0 17169000.0 3868800.0 False True 41174788.50970404 16213530.05723605 3164718.0972402436 1.0 0.3937732443583738 0.07686057929585687 25.295257903919456 -8.652645545739487 0.37301286907020587 1.1320257633222326 1.0825928702480956e-17 0.9974662118026801 0.019278461818531083 0.25853853164257373 0.12002582106931207 0.1268597901171575 0.08087457141407582 2.22512521038531e-09 8.652645545739487 -1.1320257633222326 GGAGVQVHQLLAGSGGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGAGVQVHQLLAGSGGAR 18 0 Q9UII4 Q9UII4 HERC5 E3 ISG15--protein ligase HERC5 0 72048900.0 18829500.0 35529400.0 17690000.0 False True 24685656.84513739 30228552.012516502 15859608.494462159 1.0 1.2245390998567234 0.6424624871825602 24.557169697567428 -6.802110176451784 1.4471881367894817 1.1235585003665642 0.6339935221983712 0.8382897296799638 0.09638727971812662 0.21775661554822243 0.900126334847978 0.052390126601902204 0.12169202175610042 1.5772110952246605e-07 6.802110176451784 -0.489564978168193 GGAGVQVHQLLAGSGGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGAGVQVHQLLAGSGGAR 18 0 Q9UII4 Q9UII4 HERC5 E3 ISG15--protein ligase HERC5 0 176734700.0 84511000.0 62038600.0 30185100.0 False True 128209365.58168805 50967327.12020577 24219001.754400667 1.0 0.3975320124935191 0.18890197018383678 26.933926412512154 -12.298570389087153 0.17401625991883873 2.6817961732681126 7.698484330337539e-20 0.999486599712517 0.007792087956266618 6.128397375813949 0.11748690583343127 3.809021869279569 0.16089043397690453 5.028397605546863e-13 12.298570389087153 -2.6817961732681126 GGAGVQVHQLLAGSGGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAGVQVHQLLAGSGGAR 18 0 Q9UII4 Q9UII4 HERC5 E3 ISG15--protein ligase HERC5 0 76824900.0 18829500.0 25762400.0 32233000.0 False True 25791274.998104412 24624131.983135764 24620229.25947292 1.0 0.9547465949219482 0.9545952753899309 24.62037975909032 GGAGVQVHQLLAGSGGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGAGVQVHQLLAGSGGAR 18 0 Q9UII4 Q9UII4 HERC5 E3 ISG15--protein ligase HERC5 0 194138400.0 84511000.0 64847000.0 44780400.0 False True 109401155.46086077 61238207.44490571 36630826.685705416 1.0 0.5597583241871172 0.3348303455424693 26.705052734604603 -10.241585220843128 0.14710498408731462 1.772852815463516 5.291150073964804e-12 0.9997309150644754 0.004531645543572226 1.9060966873535317 0.0723767182459496 0.7531883751490279 0.2041713124850912 5.7334334934872244e-11 10.241585220843128 -1.7728528154582248 GGAGYWNSLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGAGYWNSLFR 11 0 A0A3B3ITM6;B7ZMI3;A0A3B3ITU8;A0A3B3IU04;A0A3F2YNW8;Q14643-4;Q14643-3;Q14643-8;Q14643-7;Q14643-5;Q14643-6;Q14643-2;Q14643 A0A3B3ITM6 ITPR1 Inositol 1,4,5-trisphosphate receptor type 1 0 17759200.0 3561900.0 6094600.0 8102700.0 False True 4669685.393488661 5185309.436564726 7264310.3305866895 1.0 1.1104194393470368 1.5556316364943843 22.154893925138584 -6.94469219112363 0.6143686526237554 0.995102674834584 1.694307858612262 0.9987160691331605 0.008605750108082217 0.08568986308317758 0.04534230971184484 0.008711750743585238 0.03759998437588232 1.1358155466911249e-07 6.94469219112363 0.6992051837776779 GGAGYWNSLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGAGYWNSLFR 11 0 A0A3B3ITM6;B7ZMI3;A0A3B3ITU8;A0A3B3IU04;A0A3F2YNW8;Q14643-4;Q14643-3;Q14643-8;Q14643-7;Q14643-5;Q14643-6;Q14643-2;Q14643 A0A3B3ITM6 ITPR1 Inositol 1,4,5-trisphosphate receptor type 1 0 15353800.0 4279800.0 4632400.0 6441600.0 False True 4143940.091644074 6482141.477646875 4754351.716142264 1.0 1.5642459433034754 1.1473022319335737 21.9825717156612 -10.413529245158122 5.730947743660055 0.9998450680223997 1.3557740876185251 0.4925934176949981 0.17021655738642288 0.000337099842168858 3.449653739515097e-05 0.1648825483430035 0.054937157667197596 3.8589642466093223e-11 10.413529245158122 0.35592901959612544 GGAGYWNSLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAGYWNSLFR 11 0 A0A3B3ITM6;B7ZMI3;A0A3B3ITU8;A0A3B3IU04;A0A3F2YNW8;Q14643-4;Q14643-3;Q14643-8;Q14643-7;Q14643-5;Q14643-6;Q14643-2;Q14643 A0A3B3ITM6 ITPR1 Inositol 1,4,5-trisphosphate receptor type 1 0 17311200.0 3561900.0 5594800.0 8154500.0 False True 4878830.686728165 5347603.23647051 6228575.0471992055 1.0 1.0960829714828069 1.2766532489317035 22.218103986661475 -6.961243680695517 0.41753766649325225 0.9918037134523983 1.3877166304368174 0.999813574743676 0.0015658761114951754 0.07925982828352669 0.019511738740107785 0.002332423234093275 0.015041552371861331 1.0933427244093166e-07 6.961243680695517 0.3959129169844191 GGAGYWNSLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGAGYWNSLFR 11 0 A0A3B3ITM6;B7ZMI3;A0A3B3ITU8;A0A3B3IU04;A0A3F2YNW8;Q14643-4;Q14643-3;Q14643-8;Q14643-7;Q14643-5;Q14643-6;Q14643-2;Q14643 A0A3B3ITM6 ITPR1 Inositol 1,4,5-trisphosphate receptor type 1 0 12543800.0 4279800.0 4698000.0 3566000.0 False True 3558843.32728732 4672690.941520007 4311634.112678913 1.0 1.3129802331258293 1.2115268125515932 21.762976991095478 -10.126867336100574 4.4920482200892495 0.999969676945769 1.2622535227851774 0.8990856211038228 0.041418185545487325 1.3015289809122269e-05 2.529787662041439e-06 0.04010777870304664 0.013367661899116633 7.466768108803011e-11 10.126867336100574 0.26228384583940845 GGAGYWNSLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGAGYWNSLFR 11 0 A0A3B3ITM6;B7ZMI3;A0A3B3ITU8;A0A3B3IU04;A0A3F2YNW8;Q14643-4;Q14643-3;Q14643-8;Q14643-7;Q14643-5;Q14643-6;Q14643-2;Q14643 A0A3B3ITM6 ITPR1 Inositol 1,4,5-trisphosphate receptor type 1 0 48742000.0 10732000.0 20756000.0 17254000.0 False True 13892785.559346793 19600910.354009636 14113949.040990274 1.0 1.4108697114973123 1.0159193043539556 23.727832558688853 -12.980583463883312 11.176447089382016 1.0176280400101876 1.1920562774622188 0.0 0.19645963616191497 0.0 0.0 0.0 0.055859974418587845 1.0457227013450562e-13 12.980583463883312 0.17442823745203118 GGAHDYYNVLPNK(ub)SLWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGAHDYYNVLPNKSLWK 17 1 Q8IYS1 Q8IYS1 PM20D2 Peptidase M20 domain-containing protein 2 1 6759800.0 1579800.0 2487200.0 2692800.0 True False 1313673.6970065222 2473800.9599294565 3255852.029899545 1.0 1.8831167629880423 2.4784328386255114 20.325175538918124 -8.173753470362575 0.14916177623022006 1.1275120608184862e-09 3.644830778609787 0.9999331080968916 0.004967503720274665 0.08827083964079405 0.029832250945426523 0.3140423556067537 0.33968801733227927 6.702649810278668e-09 8.173753470362575 3.6448307774822752 GGALLTSTSGPGFHLMLPFITSYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGALLTSTSGPGFHLMLPFITSYK 24 0 E5RHW4;O94905-2;O94905-3;O94905 E5RHW4 ERLIN2 Erlin-2 0 150178000.0 49628000.0 45523000.0 55027000.0 False True 75289304.2927905 37399064.97717754 44150889.3308091 1.0 0.49673808688332866 0.5864164869834887 26.1659415923259 -10.434962117340106 6.6924480773864685 1.0000758185897323 0.5415772869334778 0.9720992841183851 0.03661105353242466 4.1423780799454504e-05 3.4973615379738104e-06 0.03545431448220683 0.0118161667181824 3.6731433921352235e-11 10.434962117340106 -0.4584985316562544 GGALLTSTSGPGFHLMLPFITSYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGALLTSTSGPGFHLMLPFITSYK 24 0 E5RHW4;O94905-2;O94905-3;O94905 E5RHW4 ERLIN2 Erlin-2 0 103799000.0 49628000.0 26711000.0 27460000.0 False True 64244424.3141319 25224509.369143944 22462561.76339358 1.0 0.3926334407762027 0.3496421985752384 25.93706791441835 -13.999999999999998 0.3759707938367034 9.784503645055587 0.3455957818099877 0.9998009437518538 0.004189831179288982 23.53380756354666 0.19957567961853548 167.04487073415956 0.011795381710016931 1.0000000000000041e-14 13.999999999999998 -9.4389078632456 GGAPFQFGGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGAPFQFGGQR 11 0 Q9BTC0 Q9BTC0 DIDO1 Death-inducer obliterator 1 0 176606000.0 51493000.0 66433000.0 58680000.0 False True 67507821.65892132 56521455.35380573 52608356.4983063 1.0 0.8372578756781184 0.779292757572692 26.00855133103867 -13.999999999999998 0.14377905466962904 1.780375784658141 0.7107219320434558 0.9995883034858469 0.0018956439922084459 11.93977307027289 0.1190629800312409 2.6091292693027097 0.06147041243146913 1.0000000000000041e-14 13.999999999999998 -1.0696538526146853 GGAPFQFGGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGAPFQFGGQR 11 0 Q9BTC0 Q9BTC0 DIDO1 Death-inducer obliterator 1 0 112169000.0 23732000.0 53596000.0 34841000.0 False True 22978640.650240004 74997162.29944769 25715096.89240449 1.0 3.2637771503104283 1.119086950521414 24.45379011906398 -6.633410443124073 2.067633437885335 2.487624594835431 1.1277210729629858 0.13011737839114812 0.9701894561646015 0.5501249498412811 4.486074784462217 0.3831491287505305 1.0748705895620285 2.3258920640402182e-07 6.633410443124073 -1.3599035218724451 GGAPFQFGGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAPFQFGGQR 11 0 Q9BTC0 Q9BTC0 DIDO1 Death-inducer obliterator 1 0 239456000.0 51493000.0 110030000.0 77933000.0 False True 70531353.64600174 105168510.779447 59526830.48051685 1.0 1.4910887902037133 0.8439768614010046 26.071761392561562 -6.70378952652989 1.8174134682346694 1.3038061532235616 0.845761822436586 0.43557580468796275 0.20715422949076845 0.3876791433330125 2.492028805928978 0.09084553749695307 0.23253905715281348 1.9779279771893913e-07 6.70378952652989 -0.4580443307869756 GGAPFQFGGQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGAPFQFGGQR 11 0 Q9BTC0 Q9BTC0 DIDO1 Death-inducer obliterator 1 0 268270000.0 268270000.0 0.0 0.0 False True 347280803.3922821 0.0 0.0 1.0 0.0 0.0 28.371527424307285 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 GGAPGIEGTGLEQGPSVGAISTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAPGIEGTGLEQGPSVGAISTR 23 0 Q8N3D4 Q8N3D4 EHBP1L1 EH domain-binding protein 1-like protein 1 0 5358450.0 937850.0 2152200.0 2268400.0 False True 1284598.489443278 2057108.6876263393 1732650.6391644685 1.0 1.6013631531809238 1.3487876977929254 20.292886074420256 -10.10177183661708 4.578900523511054 0.9999705229140823 1.4750754253926164 0.8250883028576556 0.10311349800414538 71788497.08968285 1.7023005316119892 27726.209301433813 0.03529849300497269 7.910941324913402e-11 10.10177183661708 0.4751049024785341 GGAQSGEFEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGAQSGEFEK 10 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 0 7918700.0 1761800.0 3879000.0 2277900.0 False True 2309736.861295472 3300268.320223571 2042204.7591597151 1.0 1.4288503489408466 0.8841720428769081 21.13929707008757 -6.696752194704763 1.8422608164438419 1.2671381674047786 0.8858770729203166 0.40227008452610447 0.18113239099017706 0.40231520782642616 2.652208237833416 0.07850348995163235 0.20271796373407616 2.0102395135780336e-07 6.696752194704763 -0.381261094484462 GGAQSGEFEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAQSGEFEK 10 0 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 0 7201300.0 1761800.0 3108000.0 2331500.0 False True 2413185.0708547966 2970678.2832184103 1780847.7187497607 1.0 1.2310196673668874 0.737965662169023 21.20250713161046 -6.779285267367508 1.5385061695215725 1.1309321833399464 0.7341376999297565 0.7648809564634773 0.09766725534358403 0.2516986124202667 1.1766925988057904 0.05000044061205388 0.11805806711186462 1.662320392563986e-07 6.779285267367508 -0.39679448341018986 GGAQSGEFEKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGAQSGEFEKR 11 1 P25054-2;P25054-3;P25054 P25054-2 APC Adenomatous polyposis coli protein 0 4051250.0 781880.0 2657500.0 611870.0 False True 1070962.1655125136 2540082.8628226905 467358.90785820957 1.0 2.3717764685058906 0.43639161392275044 20.030476083407102 -6.716315413279693 1.772624285279056 1.8378316753634794 0.44002143378692415 0.4950841576109325 0.5775229849316202 0.36250978733117106 2.224074201637916 0.25889960007699153 0.652755915646169 1.9216955599905176e-07 6.716315413279693 -1.3978102415765552 GGASIYGK(ub)QFEDELHPDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGASIYGKQFEDELHPDLK 19 1 Q9Y3C6 Q9Y3C6 PPIL1 Peptidyl-prolyl cis-trans isomerase-like 1 1 8271100.0 2500700.0 2163000.0 3607400.0 True False 2421316.647313976 3026697.1798959873 2662513.7203197367 1.0 1.2500212160411048 1.0996140150745364 21.2073603292218 -10.153725318832725 4.397800224824099 0.9999668233838699 1.1748176154589551 0.6430153818244881 0.061403482692151845 1.9977896926478952e-05 3.844484559738702e-06 0.05946494317166401 0.019817888818785136 7.01899092925229e-11 10.153725318832725 0.17485079207508525 GGASIYGK(ub)QFEDELHPDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGASIYGKQFEDELHPDLK 19 1 Q9Y3C6 Q9Y3C6 PPIL1 Peptidyl-prolyl cis-trans isomerase-like 1 1 50213800.0 10815700.0 6837100.0 32561000.0 True False 16408207.633584559 5616966.086493884 26125304.0780067 1.0 0.3423266094583662 1.592209500355971 23.967914317483203 -6.7637181418199726 1.5983335848611486 0.6197621578644605 1.5976582587376529 0.7060251787413068 0.27678798726660875 0.27670915896183074 1.3939833797680923 0.13657892865098378 0.32704566508519667 1.7229864346064262e-07 6.7637181418199726 0.9778961008731923 GGASIYGK(ub)QFEDELHPDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGASIYGKQFEDELHPDLK 19 1 Q9Y3C6 Q9Y3C6 PPIL1 Peptidyl-prolyl cis-trans isomerase-like 1 1 7232000.0 2500700.0 2707700.0 2023600.0 True False 2079442.8497937797 2693113.0826636334 2446725.4039307465 1.0 1.2951128149209352 1.1766254620430614 20.987765604656076 -10.121658103385037 4.421499626456451 0.9999703386316287 1.235869138420839 0.8408577313846762 0.048372259298810054 33743476.23505338 0.8334306499912266 10593.883855612135 0.016559110977946764 7.556869050862744e-11 10.121658103385037 0.23589879978921025 GGASIYGK(ub)QFEDELHPDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGASIYGKQFEDELHPDLK 19 1 Q9Y3C6 Q9Y3C6 PPIL1 Peptidyl-prolyl cis-trans isomerase-like 1 1 51779900.0 10815700.0 4783200.0 36181000.0 True False 14001136.859320479 4517010.715229282 29596429.24841016 1.0 0.3226174246145114 2.11385900629262 23.739040639575652 -6.804245384708481 1.4385358712424479 0.6282478337622823 2.141250533489629 0.8442814359786301 0.2914100699626861 0.21475306025417001 0.8768742910546109 0.1593332673407289 0.36963133560335426 1.569475769861767e-07 6.804245384708481 1.5130026997273465 GGASSSCCEEEQTQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGASSSCCEEEQTQGR 16 0 Q9UJK0 Q9UJK0 TSR3 Ribosome biogenesis protein TSR3 homolog 0 3852820.0 810410.0 2071800.0 970610.0 False True 1062455.3580216032 1762695.5158131479 870180.5879485533 1.0 1.6590772520508166 0.8190279067996941 20.018970793055548 -6.69742629073603 1.8400503041548983 1.4102707962533496 0.8216377356116105 0.40550704809142735 0.2783345743302167 0.40082661659931473 2.636587337769144 0.12076018396682128 0.3115535031708825 2.0071217135270229e-07 6.69742629073603 -0.5886330606417391 GGASSSCCEEEQTQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGASSSCCEEEQTQGR 16 0 Q9UJK0 Q9UJK0 TSR3 Ribosome biogenesis protein TSR3 homolog 0 6708410.0 810410.0 3706900.0 2191100.0 False True 1110040.4775067728 3543116.90092095 1673607.3071209963 1.0 3.191880812201582 1.5076993506399274 20.08218085457844 -6.579533985718259 2.2692593545145674 2.493038110634614 1.5118829357199366 0.0 0.952332616754211 0.7006306452242603 6.785861191757232 0.35253881277077787 1.0643617420866553 2.6330918829859866e-07 6.579533985718259 -0.9811551749146772 GGASSSCCEEEQTQGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGASSSCCEEEQTQGR 16 0 Q9UJK0 Q9UJK0 TSR3 Ribosome biogenesis protein TSR3 homolog 0 11337100.0 5561600.0 3109800.0 2665700.0 False True 7199600.835525825 2936736.8962660953 2180569.9523917786 1.0 0.40790273840947044 0.3028737290034108 22.77948549135537 -13.999999999999998 0.2432631051922371 4.982004750734762 0.2578517421293255 0.9995304973733086 0.006649544000979345 13.740905230885863 0.15608970194710753 26.630925036860187 0.05035539629967183 1.0000000000000041e-14 13.999999999999998 -4.724153008605437 GGCK(ub)IK(ub)EIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGCKIKEIR 9 2 Q15365;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;F8VXH9;H3BND9;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2 Poly(rC)-binding protein 1;Poly(rC)-binding protein 2 2 1726570.0 518750.0 448890.0 758930.0 True False 680086.2735821457 381917.36175951565 680403.2037706135 1.0 0.5615719307903145 1.0004660146819293 19.37535824811461 -10.946015571667898 10.548020863983337 1.0590170656447955 0.7810189727361219 0.24920365592730376 0.179177759443455 0.10360745179337087 0.0005302590425469549 0.0722813430444121 0.05782937319460501 1.1323597616460838e-11 10.946015571667898 -0.2779980929086736 GGCK(ub)IK(ub)EIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGCKIKEIR 9 2 Q15365;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;F8VXH9;H3BND9;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2 Poly(rC)-binding protein 1;Poly(rC)-binding protein 2 2 2032150.0 518750.0 476100.0 1037300.0 True False 710545.8936916357 455064.32774783956 792311.1038640903 1.0 0.6404432588914931 1.1150737917119526 19.4385683096375 -6.704127735385475 1.8159926182317838 0.7776330702551558 1.1137811575910972 0.4371485440092441 0.1516630668737763 0.38705598028880367 2.484309721026203 0.06655305615990026 0.17030015614409913 1.9763882561521267e-07 6.704127735385475 0.33614808733594137 GGCVYSK(ub)EEDGSTCLHHAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGCVYSKEEDGSTCLHHAAK 20 1 A0A0G2JRR0;A0A0G2JRN8;A0A0G2JIS2;A2ABF8;A0A0G2JIR1;A2ABF9;A0A0G2JK64;Q96KQ7-2;Q96KQ7;H0Y4K5 A0A0G2JRR0 EHMT2 Histone-lysine N-methyltransferase EHMT2 1 17671300.0 2088700.0 2704600.0 12878000.0 True False 3168710.60442394 2221942.998863752 10332657.65537208 1.0 0.7012136090186415 3.2608398005631436 21.595464474980815 -6.8778142561495645 1.0919601392154072 0.8196807801960305 3.4347733796120927 0.9718772415162098 0.19163294583882887 0.12958178403529264 0.2841600038826871 0.1354464033162688 0.3257893811122002 1.3249080653194622e-07 6.8778142561495645 2.6150925994160623 up GGCVYSK(ub)EEDGSTCLHHAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGCVYSKEEDGSTCLHHAAK 20 1 A0A0G2JRR0;A0A0G2JRN8;A0A0G2JIS2;A2ABF8;A0A0G2JIR1;A2ABF9;A0A0G2JK64;Q96KQ7-2;Q96KQ7;H0Y4K5 A0A0G2JRR0 EHMT2 Histone-lysine N-methyltransferase EHMT2 1 17913500.0 2088700.0 4087800.0 11737000.0 True False 2703863.324432319 3860310.3365350035 9600986.431789884 1.0 1.4277017265084886 3.5508401423380485 21.366590797073265 -6.939966205763662 0.6598769494062856 0.976154818796553 4.122815952879922 0.9981594819081848 0.04785286931096575 0.08778203852978937 0.05467971146271284 0.04656927715079339 0.18276148293810707 1.1482429675192813e-07 6.939966205763662 3.146661134083369 up GGDEYDNHCGK(ub)EQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGDEYDNHCGKEQR 14 1 F5H4U1;H0YGE9;F5GX30;P20645 F5H4U1 M6PR Cation-dependent mannose-6-phosphate receptor 1 4860110.0 381400.0 662710.0 3816000.0 True False 500019.09348285384 563836.251223348 3421156.92565673 1.0 1.1276294416998747 6.842052574086443 18.931623660418353 -6.9117169904726525 0.8839677660876163 0.8325334391098081 7.6083069202954885 0.9915533972490496 0.25038576476212226 0.10329335602220989 0.1326920007071096 0.20675064674644664 0.5777433733644941 1.2254144847950728e-07 6.9117169904726525 6.775773481185681 up GGDEYDNHCGK(ub)EQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGDEYDNHCGKEQR 14 1 F5H4U1;H0YGE9;F5GX30;P20645 F5H4U1 M6PR Cation-dependent mannose-6-phosphate receptor 1 6054160.0 381400.0 597660.0 5075100.0 True False 522413.8869474504 571253.4050026755 3876465.9049654333 1.0 1.0934881695825551 7.42029643893323 18.994833721941244 -6.910116450587732 0.8949476497566898 0.8048304704794075 8.23995278642104 0.99096529727621 0.2856059636067582 0.10434089561935758 0.13835225114287936 0.23396415747343569 0.646364048309736 1.2299389339811677e-07 6.910116450587732 7.435122315941632 up GGDINFVFTGFSVNGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGDINFVFTGFSVNGK 16 0 A0A0G2JN29;A0A087X117;Q15155;I3L0Q6;H3BTW1;Q5JPE7-2;Q5JPE7;J3KN36;P69849 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO3;NOMO2 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 12856800.0 5313800.0 2396700.0 5146300.0 False True 5145116.327627068 3353714.808625392 3798329.6443093307 1.0 0.6518248752933693 0.7382397991497158 22.294772265178786 -9.80038318664647 5.993839854471148 1.0000000196762677 0.6950323372209779 0.9432016465802218 0.035278744936931956 9.296702113585449e-09 1.7833356951365863e-09 0.03415850044807857 0.011386165967691542 1.5834954264504636e-10 9.80038318664647 -0.3049676824552898 GGDINFVFTGFSVNGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGDINFVFTGFSVNGK 16 0 A0A0G2JN29;A0A087X117;Q15155;I3L0Q6;H3BTW1;Q5JPE7-2;Q5JPE7;J3KN36;P69849 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO3;NOMO2 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 13817000.0 5313800.0 3560600.0 4942600.0 False True 4418660.141254125 3541418.3410762358 5976074.807999656 1.0 0.8014688226442991 1.3524631035107166 22.075177540613062 -6.809274387554753 1.4178567863068723 0.8917098617552106 1.3619177871139003 0.8578499797470307 0.08590570632205241 0.20779747452098218 0.8235075255594383 0.047645719214480006 0.11023691194796136 1.5514065205385187e-07 6.809274387554753 0.4702079253586897 GGDINFVFTGFSVNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGDINFVFTGFSVNGK 16 0 A0A0G2JN29;A0A087X117;Q15155;I3L0Q6;H3BTW1;Q5JPE7-2;Q5JPE7;J3KN36;P69849 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO3;NOMO2 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 42870000.0 12275000.0 11579000.0 19016000.0 False True 15890229.476423988 10934618.471240971 15555283.12063699 1.0 0.6881347111735827 0.978921238596085 23.921636623517752 -10.492751028912265 8.47826647364558 1.000008332001029 0.8335279751316677 0.30410151792330187 0.1187131027101598 1.869733265408625e-05 1.1186033272564173e-06 0.11494921705612406 0.03831448914775494 3.215503384863472e-11 10.492751028912265 -0.16648035686936125 GGDISVCEWYQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGDISVCEWYQR 12 0 P14854 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 GGDISVCEWYQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGDISVCEWYQR 12 0 P14854 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 GGDLMAYDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGDLMAYDR 9 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 17482470.0 838170.0 10081000.0 6563300.0 False True 1098848.9868498275 8576954.095430234 5884192.675619189 1.0 7.805398374182959 5.3548692732455905 20.06756170184183 -9.528037101595531 8.57464024590324 1.0000000000196636 6.580133823703227 0.8736362745098591 1.0004243161898076 0.0 0.0 0.9686566789359364 0.32288555964531207 2.9645781160402795e-10 9.528037101595531 5.580133823683564 GGDLMAYDR ddPTM_RPMI8226_Bortezomib_2h_R1 2 GGDLMAYDR 9 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 19026760.0 5164600.0 1971260.0 11890900.0 False True 5000652.599959109 2758394.3979851003 8776316.570646433 1.0 0.5516068838710484 1.7550342470737117 22.25368495246905 -6.805800506902567 1.4320728023614848 0.754389990303091 1.7741332859903065 0.8485904896276346 0.1932280757766747 0.21258202060585715 0.8599983833980122 0.10611868382894797 0.24597860124570786 1.5638658391875727e-07 6.805800506902567 1.0197432956872157 GGDLMAYDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGDLMAYDR 9 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 15359370.0 838170.0 6364600.0 8156600.0 False True 1148064.0996925673 6083390.927082334 6230179.07045005 1.0 5.298825151584625 5.426682248942711 20.13077176336472 -10.14912636066095 0.7561153782164532 1.9393061869279763e-15 5.401694244557874 0.9998950651962556 0.02107434235051541 1.4432863484613767 0.3897023044730821 3.2792059944166896 0.018987592444947306 7.09371341962608e-11 10.14912636066095 5.401694244557873 GGDVCPKPVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGDVCPKPVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGR 48 1 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 2825160000.0 853630000.0 801910000.0 1169620000.0 False True 1295019118.7123132 658802895.148573 938444094.3373426 1.0 0.508720593873275 0.724656555858784 30.270326250946614 -10.299857666376218 5.722485942879193 1.0000377569671457 0.6166885748660268 0.8077434540451136 0.08815548733026456 4.246930855181798e-05 5.19612456830016e-06 0.08536456935266858 0.028452061192241224 5.013515172850994e-11 10.299857666376218 -0.3833491821011189 GGEDTNDLQQK(ub)LEEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGEDTNDLQQKLEEVR 16 1 B9EGQ5;A0A669KBG4;M0QXA7;A0A669KBH9;A0A2R8YFV2;A0A669KAV7;O95785-2;O95785-4;O95785-3;O95785 B9EGQ5 WIZ Protein Wiz 1 20627200.0 5524000.0 11354000.0 3749200.0 True False 8380311.858494687 9327789.990793098 3008168.976667266 1.0 1.113060008779745 0.35895668651257184 22.998572501593934 -6.868721149970761 1.1407627648256815 1.0634809425495 0.3158385822169607 0.9633941051592134 0.0635324564676035 0.13809104400163238 0.33665046883187344 0.04325287790955871 0.10218749221946039 1.3529409751932644e-07 6.868721149970761 -0.7476423603325393 down GGEDTNDLQQK(ub)LEEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGEDTNDLQQKLEEVR 16 1 B9EGQ5;A0A669KBG4;M0QXA7;A0A669KBH9;A0A2R8YFV2;A0A669KAV7;O95785-2;O95785-4;O95785-3;O95785 B9EGQ5 WIZ Protein Wiz 1 9716600.0 3148400.0 3750500.0 2817700.0 True False 2618034.0977689195 3730295.3120840327 3406868.0424271924 1.0 1.4248459618088927 1.3013077428328816 21.320052456661482 -10.324148475459458 5.475075117403538 0.99992761962677 1.363076852320796 0.9201076054599338 0.05043426670393493 4.457225895426242e-05 5.501930965348455e-06 0.048842462755157724 0.0162775895852062 4.7407988036459416e-11 10.324148475459458 0.3631492326940259 GGEDTNDLQQK(ub)LEEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGEDTNDLQQKLEEVR 16 1 B9EGQ5;A0A669KBG4;M0QXA7;A0A669KBH9;A0A2R8YFV2;A0A669KAV7;O95785-2;O95785-4;O95785-3;O95785 B9EGQ5 WIZ Protein Wiz 1 18044300.0 5524000.0 7230400.0 5289900.0 True False 7150926.894319019 6828021.883967583 4327192.478957595 1.0 0.954844313873777 0.6051232998054125 22.769698823686383 -6.9307047134957145 0.740986935075046 1.0051816532046753 0.5320222849626176 0.9966748790513661 0.010175876216350948 0.09227371919094886 0.07590032089739422 0.009309846188023677 0.03152203606845883 1.172992638331617e-07 6.9307047134957145 -0.47315936824205773 GGEIQPVSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGEIQPVSVK 10 0 P61604;B8ZZL8;B8ZZ54 P61604 HSPE1 10 kDa heat shock protein, mitochondrial 0 81119200.0 2170200.0 38887000.0 40062000.0 False True 2845153.216246693 33085211.180338785 35916768.54183962 1.0 11.628621963629985 12.6238433616664 21.440074915482526 -9.507576202339193 0.7018369513956634 1.1659416432524055e-20 12.462709148982345 0.999148932708685 0.15346981827849715 0.8401101441079031 0.33740960048381446 2.592949066960514 0.1539382774870395 3.1075905896891985e-10 9.507576202339193 12.462709148982345 GGEIQPVSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGEIQPVSVK 10 0 P61604;B8ZZL8;B8ZZ54 P61604 HSPE1 10 kDa heat shock protein, mitochondrial 0 82339900.0 25110000.0 7151900.0 50078000.0 False True 24312896.794519067 10007690.966665788 36961069.49220268 1.0 0.4116206740499081 1.5202248339463575 24.535218459762852 -6.762507733343172 1.6028621118162398 0.6592982927566418 1.5248057883405148 0.701146713967715 0.2475730086641975 0.27874481963465203 1.411955064795729 0.12183077960678712 0.2920779445651679 1.7277952139362367e-07 6.762507733343172 0.8655074955838731 GGEIQPVSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGEIQPVSVK 10 0 P61604;B8ZZL8;B8ZZ54 P61604 HSPE1 10 kDa heat shock protein, mitochondrial 0 72795200.0 2170200.0 34614000.0 36011000.0 False True 2972581.5874498067 33084639.026808888 27505943.469825298 1.0 11.129934722899355 9.253217333362679 21.503284977005418 -9.39117185696138 9.173140063813456 1.0000018115962277 10.191576028131106 0.9696814694527762 0.7661666659635153 0.0 0.0 0.7418377065318207 0.2472792281411247 4.062825251488658e-10 9.39117185696138 9.191574216534878 GGELTLLGTQDDISAAK(ub)QK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGELTLLGTQDDISAAKQK 19 1 Q8TDB6 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 91895900.0 5236700.0 7424200.0 79235000.0 True False 6779011.380789364 7011036.743603694 64815043.019755654 1.0 1.0342270206938806 9.561135006120677 22.692643462150667 -6.907780468963785 0.910717704628492 0.7171015149587393 10.612335677107922 0.9900566453445948 0.40162908319724727 0.10590410071944094 0.14686451445446885 0.3252523116870712 0.8846175776145704 1.236572349073166e-07 6.907780468963785 9.895234162149182 up GGEMEILNNTDNQGIK(ub)SLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGEMEILNNTDNQGIKSLSK 20 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2;E9PDT6 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 1 6938100.0 1597700.0 2714300.0 2626100.0 True False 2094600.1721488107 2309337.020258532 2354376.3633299624 1.0 1.1025192544930553 1.1240218513467666 20.998243450619352 -13.999999999999815 0.21952905769437525 0.3826289506772162 1.1355756682850866 0.9994974137667897 0.0012131156901140263 12.986559516959149 0.14843068089462053 3.474831463199755 0.01193686822000346 1.0000000000004254e-14 13.999999999999815 0.7529467176078704 GGEMEILNNTDNQGIK(ub)SLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGEMEILNNTDNQGIKSLSK 20 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2;E9PDT6 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 1 7080400.0 1597700.0 2810500.0 2672200.0 True False 2188412.8662190414 2686322.8169193515 2041081.395686518 1.0 1.2275210305999331 0.9326765653744896 21.061453512142243 -6.700640011887989 1.8287385257635929 1.14119321875333 0.9335471528745457 0.4205692570793773 0.09602820626781008 0.39418055129233753 2.5633511675850817 0.041886343229998506 0.10762954833213496 1.9923240986737333e-07 6.700640011887989 -0.2076460658787843 GGEMEILNNTDNQGIK(ub)SLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGEMEILNNTDNQGIKSLSK 20 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2;E9PDT6 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 1 7739300.0 2644900.0 3308400.0 1786000.0 True False 2199351.5389369223 3290576.9925340186 2159444.342469022 1.0 1.4961578148277972 0.9818550169168546 21.068646788772597 -6.654349263154671 1.9927532355936037 1.3208493512671442 0.9840075529466855 0.2118509866123498 0.2115423218416414 0.4980508062068195 3.7957049689918763 0.08594169967994823 0.23441291652974203 2.2164132453155815e-07 6.654349263154671 -0.3368417983204587 GGENIK(ub)SINQQSGAHVELQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGENIKSINQQSGAHVELQR 20 1 Q96I24 Q96I24 FUBP3 Far upstream element-binding protein 3 1 6802400.0 1562800.0 1450200.0 3789400.0 True False 1513189.7694334688 2029272.4226930933 2796842.4604367763 1.0 1.341056134322692 1.8483091261474105 20.5291614969003 -6.965398468704773 0.3511522719574159 0.951625432403903 2.254886520659716 0.9999211186638597 0.003095462229938164 0.07782606599842627 0.014385019357991307 0.006942700042147268 0.04356665162726483 1.0829328583949554e-07 6.965398468704773 1.3032610882558133 GGENIK(ub)SINQQSGAHVELQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGENIKSINQQSGAHVELQR 20 1 Q96I24 Q96I24 FUBP3 Far upstream element-binding protein 3 1 5902600.0 1562800.0 2404700.0 1935100.0 True False 1299537.4437788273 2391745.403804423 2339720.4631085144 1.0 1.8404590150551152 1.8004255855106546 20.309566772334577 -10.270179405688499 5.7278209728507266 0.9999458305353656 1.8204423002828867 0.9982174735163647 0.016343579172964858 1.1306633260250478e-05 1.440670140099397e-06 0.015825639203956698 0.005274867496188106 5.368099960350044e-11 10.270179405688499 0.8204964697475211 GGFCNFMHLK(ub)PISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGFCNFMHLKPISR 14 1 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 1 4178950.0 526050.0 1512600.0 2140300.0 True False 689656.6442754472 1286925.976068619 1918842.2872073122 1.0 1.866038682800863 2.7823153784347956 19.395518748079567 -6.970411230408656 0.24816652341844334 0.7025788687103934 3.972549391905945 0.9999854150613432 0.0027791871683355697 0.07616947070321906 0.008551305699621517 0.020692926050945037 0.0880819569709136 1.0705051713126634e-07 6.970411230408656 3.2699705231955516 GGFCNFMHLK(ub)PISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGFCNFMHLKPISR 14 1 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 1 3870150.0 526050.0 2440430.0 903670.0 True False 720544.900966719 2332603.7331771883 690241.7576678522 1.0 3.2372774133126896 0.9579441291469684 19.45872880960246 -6.650466381659002 2.007298139739794 2.4512617410143953 0.9676021777786742 0.1958252847140345 0.9547904952632862 0.5073527130578822 3.9190553774450705 0.38573343378047276 1.0573006334314634 2.2363183033891767e-07 6.650466381659002 -1.483659563235721 GGFCNFMHLKPISR ddPTM_RPMI8226_Bortezomib_1h_R1 2 GGFCNFMHLKPISR 14 1 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 0 330775100.0 98479200.0 82444000.0 149851900.0 False True 129107184.87392934 70143676.5641949 134346662.86892557 1.0 0.5432980095777694 1.0405823889670625 26.943994048617412 -6.665212819950898 1.954424171613658 0.7072989665595298 1.0385333624337385 0.2580154771245037 0.1942133248695881 0.4721838627444943 3.472478397685264 0.0801338677552521 0.21543671340987863 2.161658973322263e-07 6.665212819950898 0.33123439587420866 GGFCNFMHLKPISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGFCNFMHLKPISR 14 1 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 0 72136100.0 46043000.0 8803300.0 17289800.0 False True 44581390.16766393 12318503.598603034 12761082.6971182 1.0 0.27631492764750015 0.286242368152399 25.409938268622675 -10.569766896579056 6.375721688293216 1.0012987154848731 0.2812786478999498 0.9998569283793837 0.004052860614806689 7.49259812637999e-05 5.055995699842291e-06 0.003929821980541471 0.0013080551388038504 2.692979847333522e-11 10.569766896579056 -0.7200200675849233 GGFCNFMHLKPISR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GGFCNFMHLKPISR 14 1 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 0 158623800.0 42792800.0 49329700.0 66501300.0 False True 64919806.1727356 40526429.62029475 53357288.906444795 1.0 0.6242537063721957 0.821895382196216 25.952155356733734 -10.127536218781186 4.890855010748183 1.0000149716249567 0.7230745442829192 0.7235755536365664 0.080686876284014 1.3172844473061112e-05 2.349924772995729e-06 0.07812895344395841 0.02604157734149003 7.455276947919489e-11 10.127536218781186 -0.2769404273420375 GGFCNFMHLKPISR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GGFCNFMHLKPISR 14 1 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 0 266545900.0 98479200.0 82834800.0 85231900.0 False True 134889621.54031292 79174884.63794725 65101880.62608094 1.0 0.5869605365768275 0.48263076048904685 27.007204110140304 -13.999999999999998 0.19322035708403862 3.239331823822126 0.4101612336412592 0.9994879578420754 0.005055108941723235 12.404962869044512 0.13939699593434984 10.470438359484262 0.06995376300138056 1.0000000000000041e-14 13.999999999999998 -2.829170590180867 GGFCNFMHLKPISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGFCNFMHLKPISR 14 1 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 0 92245400.0 46043000.0 5163400.0 41039000.0 False True 38286794.55074772 5135583.739345341 49620065.15710312 1.0 0.13413459652618126 1.2960099099268696 25.19034354405695 -6.707179658702983 1.805144276490553 0.4661537187143373 1.2930718206407423 0.4517121747391365 0.3650371999210029 0.380790737882043 2.416951486708026 0.16102902574978897 0.4105120912290359 1.9625482430064265e-07 6.707179658702983 0.826918101926405 GGFCNFMHLKPISR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GGFCNFMHLKPISR 14 1 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 0 285695300.0 42792800.0 91060700.0 151841800.0 False True 55396123.17219677 85993091.99621144 124208150.4284362 1.0 1.5523305074780258 2.2421812812124022 25.723281678826183 -6.968121748235047 0.29967486844981084 0.8798935641551441 2.936224094621413 0.9999638007849654 0.003057338315677793 0.07691700395620013 0.011200079712599715 0.011463331005438506 0.061890956990740036 1.076163484326456e-07 6.968121748235047 2.056330530466269 GGFEEPVLLK(ub)NIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGFEEPVLLKNIR 13 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8YG48;A0A2R8Y7R5;A0A2R8Y755 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 48847600.0 15819800.0 18163700.0 14864100.0 True False 20739910.99916113 15453746.761548046 13326105.518515272 1.0 0.7451211705861759 0.6425343637711017 24.305906367362464 -13.999999997868171 0.125411176977061 2.211565729884191 0.4901305081597023 0.9996668562186755 0.0027430211911380347 11.946251985675753 0.1096477665809155 3.583976432308447 0.13534975877294322 1.0000000049087176e-14 13.999999997868171 -1.7214352217244888 GGFEEPVLLK(ub)NIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGFEEPVLLKNIR 13 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8YG48;A0A2R8Y7R5;A0A2R8Y755 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 81234300.0 34881400.0 26649200.0 19703700.0 True False 33774109.05011302 37290364.53374214 14542709.871670462 1.0 1.1041109767962138 0.43058752046108517 25.00941437644385 -6.8674424257922135 1.1476167827127393 1.0580561072445038 0.3930262864368055 0.962059135973151 0.05766193860919305 0.13932654730028932 0.344566266592172 0.03905328047969265 0.09206630587259795 1.356930405979122e-07 6.8674424257922135 -0.6650298208076983 down GGFEEPVLLK(ub)NIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGFEEPVLLKNIR 13 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8YG48;A0A2R8Y7R5;A0A2R8Y755 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 71732900.0 30790400.0 15253000.0 25689500.0 True False 46711287.87976014 12530982.977767056 20611959.06489213 1.0 0.26826455759522516 0.4412629152497256 25.477267886530743 -10.585533887707134 9.661227661157845 1.0000638950624168 0.3547637364373233 0.9488433374008834 0.07062628376550575 9.720982488751537e-05 4.170414290576065e-06 0.06839023878605167 0.02279453506902691 2.5969650940514338e-11 10.585533887707134 -0.6453001586250935 GGFEEPVLLK(ub)NIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGFEEPVLLKNIR 13 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8YG48;A0A2R8Y7R5;A0A2R8Y755 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 40173400.0 15819800.0 14109600.0 10244000.0 True False 21668807.57402014 13486191.217792284 7824578.1818025205 1.0 0.6223780967976097 0.3610986970590765 24.369116428885356 -8.11455746017164 0.18929342625454068 1.2838661744536042 8.039747615137614e-15 0.999848714369185 0.0032258435244636556 0.0906070830824383 0.03625751671529563 0.09558244701805448 0.11189362476696682 7.681438182017785e-09 8.11455746017164 -1.2838661744535962 down GGFEEPVLLK(ub)NIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGFEEPVLLKNIR 13 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8YG48;A0A2R8Y7R5;A0A2R8Y755 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 68801700.0 34881400.0 24089900.0 9830400.0 True False 29005429.60802842 23960122.927229214 11885891.189365894 1.0 0.8260564746331938 0.4097815943424605 24.789819651878126 -6.956391057889298 0.48362513402338575 1.009658746541387 0.20871713362126207 0.9996120316829583 0.004877601693917152 0.08101647431021827 0.02609358873273951 0.005913194505655958 0.034335540714431755 1.1056277796480432e-07 6.956391057889298 -0.800941612920125 down GGFEEPVLLK(ub)NIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGFEEPVLLKNIR 13 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8YG48;A0A2R8Y7R5;A0A2R8Y755 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 95850800.0 30790400.0 30370500.0 34689900.0 True False 39858779.769522175 28680354.9771849 28376694.148432128 1.0 0.7195492471928404 0.7119308296068368 25.248394208623193 GGFSFGNVEPASLPSASVFVLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGFSFGNVEPASLPSASVFVLGR 23 0 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 41665100.0 9816100.0 16186000.0 15663000.0 False True 14891741.3530358 13297481.838204775 12567201.184663208 1.0 0.8929433786797524 0.843904073186262 23.828009128306167 -13.999999999942611 0.10492703270634182 1.5219107374671106 0.7469980863370149 0.9997688393376684 0.0009909262879867773 12.044896841483968 0.09742736794204723 1.3454770806988676 0.08621770553958799 1.0000000001321426e-14 13.999999999942611 -0.7749126511300957 GGFSFGNVEPASLPSASVFVLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGFSFGNVEPASLPSASVFVLGR 23 0 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 30608100.0 9816100.0 10122000.0 10670000.0 False True 12707134.954258686 9558701.802046895 8728169.483445352 1.0 0.7522310761989176 0.6868715501065944 23.599135450398617 -13.999999999999998 0.18706272945336505 2.3149932147270302 0.6385705751860574 0.999491293650042 0.003041936331095556 12.304372490119583 0.13715082160081343 5.892071535143794 0.04602125871134806 1.0000000000000041e-14 13.999999999999998 -1.6764226395409727 GGGEGK(ub)AMYIDTEGTFRPER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGGEGKAMYIDTEGTFRPER 20 2 E9PNT5;Q06609-3;Q06609;Q06609-4 E9PNT5 RAD51 DNA repair protein RAD51 homolog 1 1 60624100.0 7980300.0 5109800.0 47534000.0 True False 12106698.538078433 4197916.266950377 38138884.06510771 1.0 0.34674327222627516 3.1502299280973993 23.529302164081805 -6.8453374350006095 1.2574285587485325 0.6523446092246562 3.2525871557624804 0.933236519034834 0.3094621173150913 0.1626597208820742 0.4972724486329329 0.1927916775009274 0.444988562606194 1.4277841779585118e-07 6.8453374350006095 2.600242546537824 up GGGEGK(ub)AMYIDTEGTFRPER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGGEGKAMYIDTEGTFRPER 20 2 E9PNT5;Q06609-3;Q06609;Q06609-4 E9PNT5 RAD51 DNA repair protein RAD51 homolog 1 1 61028000.0 7980300.0 3952700.0 49095000.0 True False 10330655.66523066 3732728.770297446 40160213.7572399 1.0 0.36132544644387804 3.8874796584697915 23.300428486174255 -6.860014235721555 1.1856175164761917 0.6534552886056716 4.058317128243423 0.9536610345902016 0.3302225786445072 0.14678947961140512 0.3920703890081636 0.21722911454679086 0.5071012131031519 1.3803390177835355e-07 6.860014235721555 3.4048618396377512 up GGGGGFGYQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGGGGFGYQK 10 0 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 9456100.0 2661400.0 3616400.0 3178300.0 False True 2576915.313776704 5060447.379276863 2345807.883043807 1.0 1.9637616153789381 0.9103162492390221 21.297213695422784 -6.666054988494624 1.9515871823949764 1.6172395050714807 0.9146579246998787 0.2616467473521663 0.4097605709378433 0.4702060394209847 3.4487862190437544 0.16927205906649376 0.454553932563648 2.157471222155003e-07 6.666054988494624 -0.702581580371602 GGGGGFGYQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGGGGFGYQK 10 0 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 26637200.0 8447300.0 8573300.0 9616600.0 False True 12815171.680351598 7043327.631501355 7715874.794894492 1.0 0.5496085270789064 0.6020890696864077 23.61134947024897 -10.236060084862691 5.004893980390735 1.000063691359726 0.5758487983836558 0.9886483660599731 0.021425091803243337 1.5228832694681607e-05 2.3244646125463577e-06 0.020747859650043964 0.006914918645250982 5.806840740263631e-11 10.236060084862691 -0.4242148929760703 GGGGGFGYQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGGGGFGYQK 10 0 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 10196700.0 2661400.0 5302900.0 2232400.0 False True 2213072.020010859 5274332.225156764 2699184.518548629 1.0 2.3832628027762444 1.21965507409713 21.07761897085706 -6.603789742753267 2.1762773338846992 1.9279932939890339 1.2235614150170742 0.031536098923695466 0.5973166570175179 0.6301213780690069 5.645615154081889 0.22735469993406857 0.664032145698282 2.4900625534478254e-07 6.603789742753267 -0.7044318789719597 GGGGGFGYQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGGGGFGYQK 10 0 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 17707800.0 8447300.0 4195100.0 5065400.0 False True 10935196.371176884 3961638.9972107285 4143549.1753930785 1.0 0.36228329723029595 0.37891858863318567 23.38247579234142 -9.789093211878628 6.518950736373607 1.0000000080368325 0.37060094298798457 0.9994763480218452 0.006791329277156188 7.907608817925592e-10 1.5030826122732577e-10 0.006575676394997209 0.002191892099004031 1.6251999044513919e-10 9.789093211878628 -0.6293990650488479 GGGGGGPGEGFDVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGGGGGPGEGFDVAK 15 0 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 0 3092700.0 903650.0 398350.0 1790700.0 False True 874964.1253830023 557413.2323678075 1321661.9501515096 1.0 0.6370698137181434 1.5105327313539536 19.738864340304 -6.793851708891355 1.4808742304606566 0.7981705635344407 1.520838608854695 0.8135782770018973 0.15469429184559552 0.22965358343419523 0.9947925902078422 0.08220575417742737 0.19194093380915084 1.6074900414450943e-07 6.793851708891355 0.7226680453202543 GGGGGGPGEGFDVAK(ub)TGDAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGGGGGPGEGFDVAKTGDAR 20 1 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 1 7906100.0 3121500.0 2529100.0 2255500.0 True False 4092316.728649 2151768.1383545855 2022122.496283739 1.0 0.5258068426841807 0.4941265865683138 21.96448637744945 -13.999999999999998 0.3844745903370302 8.238145993875612 0.4915586286190461 0.9998146317280392 0.0031500388375271244 24.610516207178353 0.20266510561418655 147.71079684828965 0.00847322334631057 1.0000000000000041e-14 13.999999999999998 -7.746587365256566 GGGGGGPGEGFDVAK(ub)TGDAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGGGGGPGEGFDVAKTGDAR 20 1 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 1 12331800.0 2995800.0 2454600.0 6881400.0 True False 2900699.9688180108 3434734.580569902 5078954.902425086 1.0 1.1841054288594701 1.750941137319583 21.467969648767877 -6.950865833393865 0.5492558628941248 0.9921260353741648 1.9695156811191576 0.9992674906926047 0.00864906172433801 0.08313991812660901 0.03453781707676003 0.009396485514799076 0.04701725246955791 1.1197837648668349e-07 6.950865833393865 0.9773896457449929 GGGGGGPGEGFDVAK(ub)TGDAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGGGGGPGEGFDVAKTGDAR 20 1 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 1 35291000.0 6213200.0 5799800.0 23278000.0 True False 9425878.645763787 4764780.375955766 18677093.09689016 1.0 0.5054998642590387 1.981469717444759 23.168195676703135 -6.816384164743147 1.3876836782325244 0.7324587707716567 2.011197579948626 0.8758049974962607 0.21616905969094702 0.19822740551494458 0.7510496368356226 0.12244963057231731 0.28250247843716525 1.5262154135175968e-07 6.816384164743147 1.2787388091769696 GGGGGGPGEGFDVAK(ub)TGDAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGGGGGPGEGFDVAKTGDAR 20 1 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 1 13306100.0 2995800.0 4691900.0 5618400.0 True False 2491140.4364426746 4666623.803430773 6793181.463453511 1.0 1.8732881274628854 2.7269363718225823 21.248374924202153 -6.971404321322549 0.22209834457054964 0.6166184370347387 4.007769828318928 0.9999913612479437 0.0020722106047396183 0.07584960880204164 0.007378046671870226 0.023270083668356905 0.08614133769954038 1.0680600691157535e-07 6.971404321322549 3.391151391284189 GGGGGGPGEGFDVAK(ub)TGDAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGGGGGPGEGFDVAKTGDAR 20 1 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 1 41989700.0 6213200.0 6698500.0 29078000.0 True False 8043109.880482061 6325722.58654527 23786102.36547552 1.0 0.786477206023964 2.9573265464390137 22.939321998795585 -6.882729628020051 1.0645083809650633 0.8622292430409788 3.1194272963412093 0.9758193089072824 0.15191201987582212 0.12523742624167158 0.2579346319199366 0.10964987738030002 0.26708809700824776 1.309997213839728e-07 6.882729628020051 2.2571980533002307 up GGGGGQDNGLEGLGNDSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGGGGQDNGLEGLGNDSR 18 0 P08621-2;P08621;P08621-4 P08621-2 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 0 5348600.0 1544500.0 1019200.0 2784900.0 False True 1495470.6929165558 1426171.8750577862 2055451.1447908285 1.0 0.9536608653135028 1.3744509702040135 20.51216820723163 -6.879586069355713 1.0820659520389544 0.9714315525689836 1.4040410626297894 0.9733517147970906 0.03075373940965028 0.12799921031357447 0.27448541332511595 0.021901071693644494 0.05290888928381885 1.319513781892038e-07 6.879586069355713 0.43260951006080584 GGGGGYNSYGGYGGGGGGGYNAYGGGGGGSSYGGSDYGNGFGGFGSYSQHQSSYGPMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGGGGYNSYGGYGGGGGGGYNAYGGGGGGSSYGGSDYGNGFGGFGSYSQHQSSYGPMK 58 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 75122000.0 37019000.0 25750000.0 12353000.0 False True 56160529.451414675 21154711.31433169 9911424.135487756 1.0 0.3766829038289775 0.17648380868742128 25.74305320087484 -13.142146033687002 0.17172250657290608 3.3318260012586793 2.0152734224507963e-22 0.9994967211801596 0.007867090668379012 8.75702708304982 0.1252043580026605 7.004270537910154 0.15875732070633902 7.208650439564576e-14 13.142146033687002 -3.3318260012586793 GGGGGYNSYGGYGGGGGGGYNAYGGGGGGSSYGGSDYGNGFGGFGSYSQHQSSYGPMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGGGGYNSYGGYGGGGGGGYNAYGGGGGGSSYGGSDYGNGFGGFGSYSQHQSSYGPMK 58 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 82209000.0 37019000.0 27980000.0 17210000.0 False True 47921825.25358357 26422888.40360327 14077956.589512125 1.0 0.5513748331534467 0.2937692067240152 25.51417952296729 -8.944975334810358 0.19152558007168682 1.403397399046662 4.4665923742950875e-20 0.9996526094008482 0.0054389070106477845 0.4255597248843953 0.06108119247193668 0.24745586140323597 0.14210481933228042 1.1350752789643265e-09 8.944975334810358 -1.403397399046662 down GGGGNFGPGPGSNFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGGGNFGPGPGSNFR 15 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 132879000.0 55309000.0 19879000.0 57691000.0 False True 53553246.06961591 27816788.3676155 42579996.40709816 1.0 0.5194230118461054 0.7950964606654618 25.67447068917034 -10.196859958466398 5.591236568556029 1.000011076923508 0.657259736255764 0.6733099421727993 0.11254321420685237 1.5540351603179084e-05 2.232264435989461e-06 0.1089730183687918 0.03632316619597218 6.35535832140036e-11 10.196859958466398 -0.34275134066774404 GGGGNFGPGPGSNFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGGGNFGPGPGSNFR 15 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 54335000.0 12571000.0 16615000.0 25149000.0 False True 16273407.311456278 15690360.6442412 20572140.050531127 1.0 0.9641718138029631 1.264156894545901 23.956013017046267 -6.877085107050482 1.0959899527893036 0.9785478824578305 1.2842579825254414 0.9712543147455946 0.022680375789771653 0.13024040128331216 0.2881912106842646 0.015981274325068417 0.038374389654268246 1.3271343587339192e-07 6.877085107050482 0.3057101000676109 GGGGSGGYYGQGGMSGGGWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGGGSGGYYGQGGMSGGGWR 20 0 P31942-2;P31942;P31942-3;P31942-4 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 17108000.0 5270400.0 5357600.0 6480000.0 False True 6909545.438626196 4558266.963761233 5809511.760549169 1.0 0.6597057656324696 0.8407950728672329 22.72015937183195 -10.151061413755532 4.876281024176614 1.00001810679344 0.7502504192488938 0.7172008309265003 0.0739294001031832 1.4553983141144205e-05 2.5337395390993565e-06 0.07158702036599716 0.023860611282423387 7.062176806782533e-11 10.151061413755532 -0.24976768754454615 GGGGSGGYYGQGGMSGGGWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGGGSGGYYGQGGMSGGGWR 20 0 P31942-2;P31942;P31942-3;P31942-4 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 9258600.0 3961900.0 1626000.0 3670700.0 False True 3836131.6531344145 2275270.279477984 2709233.551360442 1.0 0.5931157961220944 0.706241025160539 21.871220802731543 -10.28687864373789 8.238856795023073 1.0000004668336688 0.6496784106413189 0.9274655696901513 0.04618318136327795 3.9603410056062636e-07 3.421087446721462e-08 0.04471673303996834 0.014905557691237692 5.165606932729095e-11 10.28687864373789 -0.3503220561923499 GGGGSGGYYGQGGMSGGGWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGGGSGGYYGQGGMSGGGWR 20 0 P31942-2;P31942;P31942-3;P31942-4 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 17768900.0 5270400.0 7533300.0 4965200.0 False True 7219009.307204617 7200453.896708248 3792522.021503893 1.0 0.9974296458548889 0.5253521446106091 22.783369433354842 -6.908094794854243 0.9086128683149721 1.0155116895698804 0.46676670792416974 0.9901824774596765 0.022110242068541532 0.10569135755877679 0.1457016236358561 0.01793313029257364 0.048873746598885374 1.2356776886606987e-07 6.908094794854243 -0.5487449816457106 GGGGSGGYYGQGGMSGGGWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGGGSGGYYGQGGMSGGGWR 20 0 P31942-2;P31942;P31942-3;P31942-4 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 6463900.0 3961900.0 2502000.0 0.0 False True 3294495.3919294463 2488521.229391882 0.0 1.0 0.755357325886093 0.0 21.65162607816582 -7.324757281940105 0.8030645766664507 0.9891483658066629 8.335067603053217e-16 0.9880446812703645 0.04653806976317314 0.10644650595809203 0.13759579793219817 0.03981713094763484 0.07067047098052598 4.734157671647104e-08 7.324757281940105 -0.989148365806662 down GGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSR 33 0 P09651 P09651 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 11302000.0 1832700.0 5217900.0 4251400.0 False True 2402687.447892045 4439409.6592149 3811505.9103084416 1.0 1.8476850424759728 1.5863511143125995 21.196217557906998 -10.102667144736705 4.463977047370536 0.999933696278243 1.7170180784214961 0.9093963195698608 0.106689129564368 16287116.716839692 18430134.814619023 9152.787971272934 0.036522528147070986 7.894649535113543e-11 10.102667144736705 0.7170843821432531 GGGGYTCQSGSGWDEFTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGGGYTCQSGSGWDEFTK 18 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 6965200.0 1272900.0 3517200.0 2175100.0 False True 1668784.2267811345 2992447.469938223 1950041.517032484 1.0 1.7931901691749932 1.1685402376997882 20.67036599611749 -10.100426017355657 4.4744897621581226 0.9999601740792723 1.4808652032646734 0.44138901317289614 0.2550122667617573 177518061.6675871 5.910795561399435 83001.54809909867 0.08729748182631444 7.935494274671118e-11 10.100426017355657 0.4809050291854011 GGGGYTCQSGSGWDEFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGGGYTCQSGSGWDEFTK 18 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 11238800.0 1272900.0 4868900.0 5097000.0 False True 1743525.5288290763 4653775.898700808 3893193.576010092 1.0 2.669175656880808 2.232943258722858 20.73357605764038 -10.336855825147937 5.503645032969203 0.9996749313676055 2.4510594578018563 0.936519066525235 0.17809113079301594 0.0007104922376767461 8.560839728302066e-05 0.17247165523659638 0.057478665305704606 4.6040939255992866e-11 10.336855825147937 1.4513845264342509 GGGHVAQIYAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGGHVAQIYAIR 12 0 P62249;M0R210;M0R3H0;M0R1M5;M0QX76 P62249 RPS16 40S ribosomal protein S16 0 71840000.0 24534000.0 21998000.0 25308000.0 False True 32164311.58759398 18715984.147532396 22689370.931478146 1.0 0.5818866695331758 0.7054206918027001 24.938957475240482 -10.549287679785847 9.4024503317931 1.0000206097191013 0.6436536806679396 0.9173182058743525 0.05043255340565806 2.178967353558472e-05 1.0445539497888264e-06 0.04883392420278593 0.016277036620569157 2.8230093737377046e-11 10.549287679785847 -0.35636692905116174 GGGHVAQIYAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGGHVAQIYAIR 12 0 P62249;M0R210;M0R3H0;M0R1M5;M0QX76 P62249 RPS16 40S ribosomal protein S16 0 40931400.0 14306000.0 3615400.0 23010000.0 False True 13851863.860708486 5059048.074061925 16982990.714796565 1.0 0.36522507908933255 1.2260437213052375 23.723576777791607 -6.709156393899622 1.798473382847603 0.6094144580021185 1.223949320261052 0.46099694057193286 0.2675261585846104 0.3767622173209996 2.3750629178572855 0.1184059784277023 0.3010855170466421 1.953635804785698e-07 6.709156393899622 0.6145348622589336 GGGHVAQIYAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGGHVAQIYAIR 12 0 P62249;M0R210;M0R3H0;M0R1M5;M0QX76 P62249 RPS16 40S ribosomal protein S16 0 50821000.0 14551000.0 25525000.0 10745000.0 False True 22074930.82059312 20969864.322264723 8621246.040299207 1.0 0.9499402055974958 0.3905446458865762 24.39590558091003 -6.924447940596468 0.7910356574564561 1.0104788465068002 0.29041308665069826 0.995329970660671 0.018878795735387102 0.09562487286996081 0.09256600329522174 0.016661732372505997 0.05224569394497862 1.1900139690209091e-07 6.924447940596468 -0.720065759856102 down GGGHVAQIYAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGGHVAQIYAIR 12 0 P62249;M0R210;M0R3H0;M0R1M5;M0QX76 P62249 RPS16 40S ribosomal protein S16 0 59434000.0 24534000.0 13494000.0 21406000.0 False True 33604882.806420445 12897790.461309265 16350343.67040849 1.0 0.3838070358883993 0.4865466653936565 25.002167536763373 -10.385031384494145 7.024788262009821 1.0000270325456955 0.43517685064191447 0.9757859820017329 0.0419432781084119 1.7758472298189844e-05 1.5546522211710648e-06 0.04061334008289069 0.013537134799935456 4.120677397531212e-11 10.385031384494145 -0.564850181903781 GGGHVAQIYAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGGHVAQIYAIR 12 0 P62249;M0R210;M0R3H0;M0R1M5;M0QX76 P62249 RPS16 40S ribosomal protein S16 0 23843700.0 14306000.0 4860700.0 4677000.0 False True 11896072.863258203 4834514.444326586 5654939.075995301 1.0 0.4063958333054851 0.47536183923864056 23.503982053225883 -10.36830872481308 5.8425358512381464 1.0001139795686784 0.44087883627355845 0.9887178480849285 0.028155254022334673 4.180971698782522e-05 4.520429443752493e-06 0.02726670032720784 0.009087069161394644 4.282439884415633e-11 10.36830872481308 -0.5592351432951199 GGGHVAQIYAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGGHVAQIYAIR 12 0 P62249;M0R210;M0R3H0;M0R1M5;M0QX76 P62249 RPS16 40S ribosomal protein S16 0 51874000.0 14551000.0 19109000.0 18214000.0 False True 18836556.343091276 18045567.35183897 14899238.89142209 1.0 0.9580077708024153 0.790974667558421 24.167031903002478 -6.945003216442992 0.611249199221118 1.0018443800844687 0.7384208582403189 0.9987484752823974 0.003193835888518005 0.08555648373477445 0.04476019892398931 0.003242632383330126 0.01409086845076563 1.1350024096616068e-07 6.945003216442992 -0.26342352184414985 GGGK(ub)DVSAQATGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGGKDVSAQATGK 13 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 2537720.0 668300.0 568220.0 1301200.0 True False 647085.1823089244 795113.209228154 960376.6848367355 1.0 1.2287612681703468 1.484158053828287 19.30359611556579 -6.969700813290125 0.26523379872332975 0.9327274439056429 1.7878213913205507 0.9999799537897243 0.0008853956866070046 0.07639988735175303 0.009376911381072026 0.005156589965752602 0.023912860408182274 1.0722577322726243e-07 6.969700813290125 0.8550939474149079 GGGK(ub)DVSAQATGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGGKDVSAQATGK 13 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 2203770.0 668300.0 864830.0 670640.0 True False 555721.0607098734 860170.9891346857 810867.7233109878 1.0 1.5478466625610885 1.4591272144251508 19.084001391000065 -10.685899566792438 6.562328864102289 0.9956272185085931 1.50348693849308 0.9772424838478856 0.036219563032393924 0.002327137318923191 0.00011138638881471658 0.035220048788071404 0.011689813702614292 2.0611065014195823e-11 10.685899566792438 0.5078597199844869 GGGLFLLAGPPASVETLGPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGGLFLLAGPPASVETLGPR 20 0 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 0 8161000.0 1935100.0 3282300.0 2943600.0 False True 2536934.839535058 2792593.63430519 2639024.5090050222 1.0 1.100774679264914 1.0402413447436727 21.27465503398149 -10.302123280370292 3.7338534204267995 0.9998277300616433 1.0705080119939843 0.6439950275977433 0.024712630449535426 17546378.94023231 7.392409865319825 26364.205338281376 0.008459790703181624 4.9874289243969e-11 10.302123280370292 0.070680281932341 GGGLFLLAGPPASVETLGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGGLFLLAGPPASVETLGPR 20 0 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 0 13518000.0 5578200.0 3297200.0 4642600.0 False True 5401123.094352301 4613789.154670853 3426563.7849854263 1.0 0.8542277363564023 0.6344169027675785 22.364827997745156 -6.965169727583125 0.35512760904478047 1.0200272425796095 0.46114139098559087 0.9999165998161039 0.0013722675848172688 0.0779034227669938 0.014657141699092676 0.0029801830513324474 0.01883084563804209 1.0835033849218506e-07 6.965169727583125 -0.5588858515940187 GGGLFLLAGPPASVETLGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGGLFLLAGPPASVETLGPR 20 0 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 0 14488400.0 1935100.0 4573500.0 7979800.0 False True 2650558.764111201 4371427.6474579815 6095135.589139756 1.0 1.6492475875832284 2.2995662920846835 21.33786509550438 -6.9711048389941945 0.23027456465787915 0.7364250385949342 3.2309765148481984 0.9999897641443696 0.001697393074252941 0.07594580812895266 0.007735281429153173 0.016675921199757037 0.06455517142225978 1.0687968397676257e-07 6.9711048389941945 2.494551476253264 GGGLFLLAGPPASVETLGPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGGLFLLAGPPASVETLGPR 20 0 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 0 10065500.0 5578200.0 1853200.0 2634100.0 False True 4638520.456160133 1843216.4437686019 3184878.131297679 1.0 0.39737163200837883 0.6866150880218796 22.145233273179432 -10.487635225566088 6.273282783028894 1.0002796808019099 0.5419933600151579 0.7697520981542916 0.11808314644537131 0.0004621736733271851 3.77476218533799e-05 0.11440145463059886 0.03811117163755789 3.2536046076731894e-11 10.487635225566088 -0.458286320786752 GGGNQVSLLNVVMDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGGNQVSLLNVVMDLK 16 0 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y8B3 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 0 47292000.0 8867000.0 17381000.0 21044000.0 False True 13451887.264531588 14279224.751627158 16884644.176087126 1.0 1.0615034508412065 1.2551877550004928 23.681305257526855 -6.950355728500746 0.5549338317977204 0.9973964480456926 1.3284709541149553 0.9992288391698345 0.003019646405059819 0.08334339232356976 0.03537497781575649 0.0032570619378952115 0.016083251041200106 1.1210997907235208e-07 6.950355728500746 0.3310745060692627 GGGNQVSLLNVVMDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGGNQVSLLNVVMDLK 16 0 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y8B3 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 0 25762600.0 8867000.0 9113900.0 7781700.0 False True 11478506.294700729 8606703.453238012 6365510.446984698 1.0 0.7498104049663205 0.5545591284750575 23.452431579619304 -6.973903006622253 0.1356907476149738 1.2782820905467527 0.02101192509864814 0.9999990605346678 0.00017661238121305413 0.07505537950754645 0.004093521052885578 0.011550239069580978 0.025941528670629523 1.0619326979929057e-07 6.973903006622253 -1.2572701654481044 GGGQIIPTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGGQIIPTAR 10 0 P13639;Q15029-2;Q15029;Q15029-3;K7EP67;K7EJ74 P13639;Q15029-2 EEF2;EFTUD2 Elongation factor 2;116 kDa U5 small nuclear ribonucleoprotein component 0 33750600.0 2122600.0 18338000.0 13290000.0 False True 2782749.155287641 15602041.880964143 11914878.286681846 1.0 5.606700787714884 4.281693254327933 21.408079435330002 -10.112830862613874 8.066995127381595 0.9999997251039827 4.944197021021408 0.9219640463336758 0.5409320603569626 2.674880218446495e-06 2.94110353491349e-07 0.5237552465024645 0.17458507176601507 7.712037583763447e-11 10.112830862613874 3.9441972959174247 GGGQIIPTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGGQIIPTAR 10 0 P13639;Q15029-2;Q15029;Q15029-3;K7EP67;K7EJ74 P13639;Q15029-2 EEF2;EFTUD2 Elongation factor 2;116 kDa U5 small nuclear ribonucleoprotein component 0 32297600.0 7876800.0 4428800.0 19992000.0 False True 7626755.29554233 6197242.9358868925 14755495.45285584 1.0 0.8125661170103418 1.9347015711229258 22.862637980951497 -6.863972547767671 1.165596001399966 0.8970316498057498 1.9932864073152314 0.9582833416034044 0.10024478400306391 0.14276000636113695 0.36633835098517875 0.0669649677913462 0.15707314750639575 1.3678152839732256e-07 6.863972547767671 1.0962547575094816 GGGQIIPTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGGQIIPTAR 10 0 P13639;Q15029-2;Q15029;Q15029-3;K7EP67;K7EJ74 P13639;Q15029-2 EEF2;EFTUD2 Elongation factor 2;116 kDa U5 small nuclear ribonucleoprotein component 0 36452600.0 2122600.0 18163000.0 16167000.0 False True 2907382.581108178 17360498.602990974 12348687.569816595 1.0 5.97117789581509 4.247355559621523 21.471289496852894 -9.407488658459187 8.839929006918872 1.0000000000066522 5.10926672768445 0.8834055849355532 0.7037475218150523 0.0 0.0 0.6814006079808371 0.22713353599361233 3.913013457743848e-10 9.407488658459187 4.109266727677798 GGGSSK(ub)LFSSSFNGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGGSSKLFSSSFNGGR 16 1 Q8N5U6;Q8N5U6-2;F5H5P6;H0YGL7 Q8N5U6 RNF10 RING finger protein 10 1 22892300.0 4027600.0 3462700.0 15402000.0 True False 5280222.603333883 2946078.657498887 13808348.786416408 1.0 0.557945919863068 2.6151073209864193 22.33216732124811 -6.850476957429215 1.232731564133832 0.7639999209449503 2.6981302741732196 0.9410053559294861 0.2147557292870014 0.15693152255565027 0.45866223198828177 0.1363011650512571 0.3155171852676898 1.4109870978918183e-07 6.850476957429215 1.9341303532282694 up GGGTLCAQLPALWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGGTLCAQLPALWK 14 0 O00115-2;O00115 O00115-2 DNASE2 Deoxyribonuclease-2-alpha 0 12078800.0 3096300.0 4256500.0 4726000.0 False True 4059279.2846118556 3621446.791707051 4236998.854993109 1.0 0.8921403376790149 1.0437810650415118 21.95279217239584 -6.715674237915232 1.7747154829546372 0.9340788069712472 1.0434918758334983 0.4920996268210853 0.0454134359009114 0.36379325903646936 2.2368069818481864 0.020336426182892848 0.051316788765936844 1.924534771388943e-07 6.715674237915232 0.1094130688622511 GGGTLCAQLPALWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGGTLCAQLPALWK 14 0 O00115-2;O00115 O00115-2 DNASE2 Deoxyribonuclease-2-alpha 0 19179900.0 3096300.0 5281600.0 10802000.0 False True 4241085.78436128 5048241.448084407 8250790.074173238 1.0 1.1903181649141499 1.9454428638528074 22.01600223391873 -6.945061899263304 0.6106674834741411 0.9916553628357148 2.1834745842997254 0.9987544567300197 0.014409425689786292 0.08553153916622855 0.04465234516127781 0.014637627967449097 0.06368886354647962 1.1348490560144367e-07 6.945061899263304 1.1918192214640106 GGHMDDGGYSMNFNMSSSR ddPTM_RPMI8226_Bortezomib_1h_R1 2 GGHMDDGGYSMNFNMSSSR 19 0 P38159;P38159-2;H3BT71;H0Y6E7;Q96E39;A0A1B0GUK8 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 39371600.0 14546000.0 11700100.0 13125500.0 False True 19069946.863664374 9954490.686632607 11767399.168686435 1.0 0.521998868575757 0.6170651262331456 24.184797487954775 -9.93515274801527 5.681003072501953 1.0000003841849654 0.569531997403981 0.9647117683966259 0.03881063717120947 1.8886747693428023e-07 3.528704580186295e-08 0.037578271450768384 0.012526079284723098 1.161040186418569e-10 9.93515274801527 -0.4304683867809844 GGHMDDGGYSMNFNMSSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGHMDDGGYSMNFNMSSSR 19 0 P38159;P38159-2;H3BT71;H0Y6E7;Q96E39;A0A1B0GUK8 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 26622300.0 6431200.0 3878100.0 16313000.0 False True 6227045.076260901 5426645.554024337 12040135.920490066 1.0 0.8714639909564983 1.9335231675759283 22.57011629194111 -6.876645195515622 1.09828231862601 0.9233689218370839 2.004127519678235 0.9708796985890964 0.08076389909955316 0.13064597893394334 0.2905651527209356 0.056805264899514214 0.13627863267180929 1.328479338979523e-07 6.876645195515622 1.0807585978411511 GGHMDDGGYSMNFNMSSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGHMDDGGYSMNFNMSSSR 19 0 P38159;P38159-2;H3BT71;H0Y6E7;Q96E39;A0A1B0GUK8 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 39299900.0 7233900.0 19681000.0 12385000.0 False True 10974355.168929178 16168771.781645127 9937099.321461674 1.0 1.4733231732304863 0.90548366336783 23.38763283659917 -6.685486249385871 1.8823006099331672 1.297988397040849 0.9075386581588579 0.34943337076906855 0.20036941686237617 0.4264567366980659 2.9257720110285574 0.0852688929773768 0.2233304317845712 2.0630689870825424e-07 6.685486249385871 -0.3904497388819911 GGHMDDGGYSMNFNMSSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGHMDDGGYSMNFNMSSSR 19 0 P38159;P38159-2;H3BT71;H0Y6E7;Q96E39;A0A1B0GUK8 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 33381800.0 11912000.0 7450800.0 14019000.0 False True 16316188.309695922 7121599.019499275 10708000.93036796 1.0 0.4364744316702482 0.6562807885714773 23.95980072709795 -10.209518945157276 5.459185258246228 1.000021943806287 0.5463776101208203 0.8502697570719857 0.08973556943817702 2.3967636986398388e-05 3.470706545072308e-06 0.0868902874796387 0.028962030499684988 6.172783638680667e-11 10.209518945157276 -0.45364433368546664 GGHMDDGGYSMNFNMSSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGHMDDGGYSMNFNMSSSR 19 0 P38159;P38159-2;H3BT71;H0Y6E7;Q96E39;A0A1B0GUK8 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 15062900.0 6431200.0 4765800.0 3865900.0 False True 5347827.750467369 4740125.689462765 4674241.816097986 1.0 0.8863646906070424 0.8740449457612923 22.350521567375385 -13.999999999999998 0.31377193598635894 2.123017313538136 0.8714254724661048 0.9996802447881656 0.0010137958276811283 17.542909058182897 0.17837685217008226 12.8892521851141 0.004204322035494961 1.0000000000000041e-14 13.999999999999998 -1.251591841072031 GGHMDDGGYSMNFNMSSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGHMDDGGYSMNFNMSSSR 19 0 P38159;P38159-2;H3BT71;H0Y6E7;Q96E39;A0A1B0GUK8 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 29602900.0 7233900.0 13040000.0 9329000.0 False True 9364426.151487041 12314312.536918743 7631217.723623398 1.0 1.3150098401879402 0.8149156819835228 23.15875915869162 -6.736447912320665 1.6996367874084886 1.1881987577572275 0.81484138570866 0.5888848172301966 0.13236993935324917 0.3242991510720534 1.8380198345114824 0.06164647437042965 0.1518725429726283 1.83464519450489e-07 6.736447912320665 -0.37335737204856745 GGIGAGLGGGLCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGIGAGLGGGLCR 13 0 Q9NXV2;H3BSS5 Q9NXV2 KCTD5 BTB/POZ domain-containing protein KCTD5 0 24917200.0 5187700.0 6291500.0 13438000.0 False True 6801124.937758267 5352832.724074921 12047564.666398115 1.0 0.7870510794996921 1.7714076386853053 22.69734196390725 -6.850068795063496 1.2347210013108911 0.8863542225532445 1.8108187926074577 0.940410556462491 0.1032266922232224 0.15738129757929628 0.4616723425935896 0.06541757374080179 0.1513902920522126 1.4123138072327924e-07 6.850068795063496 0.9244645700542132 GGIMLPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGIMLPEK 8 0 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 0 17409300.0 7175000.0 2733900.0 7500400.0 False True 6947233.552396436 3825560.527100161 5535820.232823124 1.0 0.5506595536550719 0.7968380782179911 22.728007168054404 -10.095171212707244 5.249757597745925 1.000005799897197 0.67374881593615 0.7007565918011951 0.10050196180306248 6.8225016272046326e-06 1.175872217348478e-06 0.09731233550938133 0.032436868693510576 8.032094090473802e-11 10.095171212707244 -0.32625698396104696 GGIMLPEK(ub)SQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGIMLPEKSQGK 12 1 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 1 7349300.0 3663900.0 2561000.0 1124400.0 True False 3547591.500017465 3583620.655438573 829885.9087230443 1.0 1.0101559481752425 0.23392938807045816 21.758408464298952 -6.903936080560019 0.9360436702806975 1.0288807128402824 0.14561078625911747 0.9884249874759914 0.039112969157310856 0.10856589307443372 0.161528319591818 0.031091696305204714 0.08261634738705631 1.2475671175968018e-07 6.903936080560019 -0.8832699265811649 down GGIMLPEK(ub)SQGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGIMLPEKSQGK 12 1 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 1 16036700.0 2677600.0 7579600.0 5779500.0 True False 4062114.958780849 6226961.160314901 4637179.291755163 1.0 1.532935730155648 1.141567715047362 21.953799638135052 -10.534443250960523 10.32467599229019 0.9999947427980329 1.3372517226014957 0.497511173558033 0.15977532311019316 1.935642142794334e-05 8.728070328599099e-07 0.15470420258057901 0.05156726379505728 2.9211694429976176e-11 10.534443250960523 0.3372569798034628 GGIMLPEK(ub)SQGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGIMLPEKSQGK 12 1 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 1 12814800.0 2677600.0 5134000.0 5003200.0 True False 3466205.9833867913 4848288.386851291 4092668.9371671826 1.0 1.3987306034576983 1.180734485135324 21.7249259602275 -10.146488487822916 4.265280958742326 0.9999406699116296 1.2897325442785355 0.701959017802589 0.08899654280659597 62234426.52903728 5.106978578282822 40524.29601731935 0.03046588374524181 7.136931232829992e-11 10.146488487822916 0.2897918743669059 GGIVGMTLPIAR ddPTM_RPMI8226_Bortezomib_1h_R1 2 GGIVGMTLPIAR 12 0 Q99714;Q99714-2 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 124230100.0 37765700.0 33693100.0 52771300.0 False True 49511198.42355904 28666220.81467512 47311032.09405371 1.0 0.578984587879311 0.9555622485506547 25.56125153451344 -10.303767524612292 8.18364435997078 1.0000004667958866 0.7672734182149828 0.33741439533201456 0.1537371861959568 1.3092927891959455e-06 1.1139904931160171e-07 0.14885568767415705 0.049618463485810796 4.9685821567982433e-11 10.303767524612292 -0.23272704858090376 GGIVGMTLPIAR ddPTM_RPMI8226_Bortezomib_2h_R1 2 GGIVGMTLPIAR 12 0 Q99714;Q99714-2 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 81048200.0 26208900.0 10880100.0 43959200.0 False True 25376912.815526523 15224580.668971956 32444966.772267953 1.0 0.5999382501585063 1.2785230027041325 24.59701323549328 -6.746927740202143 1.6610346094611719 0.7638991990235304 1.2795781200554563 0.6357454142324128 0.16808951233941463 0.3054216935506378 1.6569335846073387 0.07997091155568185 0.19479187328701733 1.790903807583359e-07 6.746927740202143 0.5156789210319259 GGIVGMTLPIAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGIVGMTLPIAR 12 0 Q99714;Q99714-2 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 34403500.0 4982600.0 24853000.0 4567900.0 False True 7558968.476852952 20417787.972624715 3665052.562818306 1.0 2.7011341607188863 0.48486146939776475 22.849757942015913 -6.701666602449903 1.8251284284656364 2.0546300378846527 0.49129255055154786 0.42537403630488735 0.717856202191096 0.3920790834285053 2.5403424728268384 0.3136582461679849 0.8049303941385171 1.987620180593013e-07 6.701666602449903 -1.5633374873331047 GGIVGMTLPIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GGIVGMTLPIAR 12 0 Q99714;Q99714-2 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 112453200.0 37765700.0 26765100.0 47922400.0 False True 51728699.86966789 25582529.381650276 36604116.11280872 1.0 0.4945519498094148 0.7076171681297608 25.62446159603633 -10.260304279994736 5.607333143678555 1.0000283896814877 0.6010845589695786 0.8237530114288248 0.0869835111366255 3.087352533514196e-05 4.072754228030763e-06 0.08422740451126806 0.02807380750222816 5.4915598356515214e-11 10.260304279994736 -0.3989438307119091 GGIVGMTLPIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGIVGMTLPIAR 12 0 Q99714;Q99714-2 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 47934000.0 22921000.0 12936000.0 12077000.0 False True 19059827.07246898 12866311.200405024 14602244.86226114 1.0 0.6750486849374306 0.7661268282624344 24.184031694119245 -10.115465956426354 7.282724262023449 1.0000001010247754 0.7205877565999329 0.9261925769049718 0.03718249631105552 6.098970754106871e-08 7.439985882751017e-09 0.036001810120928825 0.012000599081928048 7.665386254099581e-11 10.115465956426354 -0.27941234442484253 GGIVGMTLPIAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGIVGMTLPIAR 12 0 Q99714;Q99714-2 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 24135700.0 4982600.0 11375000.0 7778100.0 False True 6450073.921729546 10741971.25057138 6362565.610045584 1.0 1.6654028125759819 0.9864329753820097 22.620884264108362 -6.650793916785567 2.005613242182477 1.4315136368699521 0.98928544091472 0.19725957951512552 0.28394702066940297 0.5066269375051179 3.9070762904261125 0.11478080873525479 0.3145370621314213 2.2346323582730833e-07 6.650793916785567 -0.4422281959552321 GGIVSQVK(ub)VPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGIVSQVKVPK 11 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 4600850.0 528970.0 881080.0 3190800.0 True False 512178.136893539 1232899.8387715002 2355033.758051845 1.0 2.4071699863045306 4.598075529610825 18.96628614504407 -6.964630423901366 0.36433932846957584 0.8203256748635644 6.260508814374089 0.9999053234701812 0.014405328124461759 0.07808659652827613 0.015303501274430682 0.029150825041120692 0.18665673914913056 1.0848497071805703e-07 6.964630423901366 5.440183139510524 GGIVSQVK(ub)VPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGIVSQVKVPK 11 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 2726310.0 528970.0 1394100.0 803240.0 True False 439861.9923443095 1386589.7065928166 971193.7702378602 1.0 3.152328982103641 2.2079511008935766 18.746691420478346 -10.034456180652775 4.747401296891444 0.9999634888010193 2.680140041545231 0.8084382605318734 0.3855406557295149 133314015.97299281 3.516389037620208 63836.30019017223 0.13198082121015775 9.2372738575643e-11 10.034456180652775 1.6801765527442116 GGK(ub)AEDK(ub)EWMPVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGKAEDKEWMPVTK 14 2 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 2 8302300.0 2411700.0 2285300.0 3605300.0 True False 2335141.903597835 3197832.2076820657 2660963.7733183843 1.0 1.3694380640230273 1.1395297944071596 21.155078792662263 -10.153700662124304 4.121994434954561 0.9999293525037054 1.2544839289741794 0.6202940793240646 0.09385965842740533 32840905.081610415 4.102531235399564 25759.477676724215 0.03213065753931608 7.019389437943679e-11 10.153700662124304 0.25455457647047397 GGK(ub)AEDK(ub)EWMPVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGKAEDKEWMPVTK 14 2 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 2 5928700.0 2510000.0 1563900.0 1854800.0 True False 3438014.8301995285 1494801.7268742828 1416734.4408050857 1.0 0.43478629403920593 0.4120792116312262 21.713144337353985 GGK(ub)AEDK(ub)EWMPVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGKAEDKEWMPVTK 14 2 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 2 7051800.0 2411700.0 3266500.0 1373600.0 True False 2005435.4064252607 3248902.716150518 1660813.40919118 1.0 1.6200485469346375 0.8281560223131903 20.93548406809654 -6.697868485002352 1.8388337714351461 1.385832824230225 0.8306303405185469 0.40733549428547866 0.26183407087412297 0.39995456857103134 2.6277754526775965 0.11367126986169929 0.29306473272002476 2.0050791224676596e-07 6.697868485002352 -0.555202483711678 GGK(ub)AEDKEWMPVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGKAEDKEWMPVTK 14 2 P15880;E9PQD7;E9PMM9;E9PPT0 P15880 RPS2 40S ribosomal protein S2 1 3920000.0 1102800.0 1696000.0 1121200.0 True False 917027.0623235804 1686863.3113703572 1355637.736156926 1.0 1.8394913091181315 1.4782963249982892 19.806604784161095 -10.267676755277071 5.977024661576923 0.9999723502843345 1.65889381705821 0.8160739182584207 0.1474572347910553 5.433425182006802e-05 6.656788805676645e-06 0.14278082400566558 0.04759161788529508 5.3991232892781974e-11 10.267676755277071 0.6589214667738754 GGK(ub)NSTWSGESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGKNSTWSGESK 12 1 P19338 P19338 NCL Nucleolin 1 34046200.0 3212300.0 18606200.0 12227700.0 True False 3110327.294824119 26035752.6900512 9024898.546863025 1.0 8.370743726352263 2.9015912768670087 21.568634970186505 -9.562970717109181 8.030229576408761 1.0000352004507465 5.6361675015982735 0.4893043480557937 2.2327721378816276 0.0 0.0 2.1618722620042914 0.7206241088102792 2.73545316170523e-10 9.562970717109181 4.636132301147527 GGK(ub)NSTWSGESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGKNSTWSGESK 12 1 P19338 P19338 NCL Nucleolin 1 5005100.0 478270.0 783930.0 3742900.0 True False 725570.5562205381 644031.5666269538 3003114.1744286516 1.0 0.8876208676130452 4.138969185948956 19.468756386675224 -6.898892604169787 0.9682316717666204 0.8606828528064293 4.472692880483455 0.986007581222692 0.17825181226497006 0.1122253663054014 0.18204810715478428 0.1383576363297164 0.35802807499637035 1.2621396080300368e-07 6.898892604169787 3.612010027677026 up GGK(ub)NSTWSGESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGKNSTWSGESK 12 1 P19338 P19338 NCL Nucleolin 1 26914100.0 8085400.0 8630600.0 10198100.0 True False 11074790.879719235 8249271.554422397 7789518.816462347 1.0 0.7448692841260701 0.7033558376914314 23.40077612148931 -13.999999999999998 0.25552967091316436 2.8249582689279555 0.6875204735647793 0.9995533514406205 0.0027718148397870017 14.223964934331104 0.1599542201120685 13.368223046663179 0.01858659509344977 1.0000000000000041e-14 13.999999999999998 -2.1374377953631765 GGK(ub)NSTWSGESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGKNSTWSGESK 12 1 P19338 P19338 NCL Nucleolin 1 9988800.0 3212300.0 4731100.0 2045400.0 True False 2671169.779018895 4705612.625250176 2473083.6831389377 1.0 1.7616299279106549 0.9258429406337799 21.34904024562078 -6.666897623564794 1.948487456473241 1.4874353539603387 0.9292702301518483 0.2653600071911679 0.3237566638782262 0.4682598452604504 3.4244077444262704 0.13391345308200786 0.35922158911464924 2.1532892707576554e-07 6.666897623564794 -0.5581651238084904 GGK(ub)PEPPAMPQPVPTA ddPTM_RPMI8226_Bortezomib_1h_R1 2 GGKPEPPAMPQPVPTA 16 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2 P23396 RPS3 40S ribosomal protein S3 1 121886000.0 29948200.0 51288800.0 40649000.0 True False 39262380.2187813 43636710.962176554 36443031.4127412 1.0 1.1114127752576441 0.928192106786958 25.226644300738027 -6.742094788228875 1.6788883395648773 1.0661277254305552 0.9280316838352849 0.6143840816281725 0.046809317341604394 0.31403138840788286 1.7387525996424233 0.022049079841961555 0.05398544896571056 1.8109447963608994e-07 6.742094788228875 -0.13809604159527034 GGK(ub)PEPPAMPQPVPTA ddPTM_RPMI8226_Bortezomib_2h_R1 2 GGKPEPPAMPQPVPTA 16 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2 P23396 RPS3 40S ribosomal protein S3 1 103166090.0 38790600.0 44541700.0 19833790.0 True False 37559213.635900944 62327433.09189699 14638725.398054134 1.0 1.6594445692100797 0.38975058263897516 25.162663522318717 -6.7655459880033915 1.5914198794584655 1.380385365909305 0.38376627397449187 0.7132679063286678 0.27763245005940695 0.2736923901095061 1.3672262279155363 0.13756651566722 0.32883266467039685 1.7157500175168314e-07 6.7655459880033915 -0.9966190919348132 GGK(ub)PEPPAMPQPVPTA ddPTM_RPMI8226_Bortezomib_8h_R1 2 GGKPEPPAMPQPVPTA 16 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2 P23396 RPS3 40S ribosomal protein S3 1 237191600.0 118657000.0 43019600.0 75515000.0 True False 180011343.9886684 35342416.266331084 60589427.1505997 1.0 0.19633438361837832 0.33658671619280706 27.42351258454557 -9.7771932389008 6.039876695527494 1.000000030187137 0.2664605502807154 0.9733137612834651 0.057257775012604546 154330030.58211014 50.01458785198814 64.91806843432167 0.01960085935348812 1.670347229588705e-10 9.7771932389008 -0.7335394799064217 GGK(ub)PEPPAMPQPVPTA ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GGKPEPPAMPQPVPTA 16 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2 P23396 RPS3 40S ribosomal protein S3 1 120013200.0 29948200.0 49275600.0 40789400.0 True False 41020858.85967389 47098441.0593813 31155783.804062385 1.0 1.148158336238105 0.7595107628204855 25.289854362260918 -6.803374139318739 1.4419445719151363 1.081399248473425 0.7536783612431294 0.841887031698864 0.06368121568764117 0.2159748180339182 0.886137012077806 0.03473651345857783 0.08062965196073844 1.5726274816240839e-07 6.803374139318739 -0.3277208872302956 GGK(ub)PEPPAMPQPVPTA ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GGKPEPPAMPQPVPTA 16 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2 P23396 RPS3 40S ribosomal protein S3 1 126787800.0 38790600.0 57270500.0 30726700.0 True False 32256102.614952043 56961972.44919574 37151510.90579115 1.0 1.765928547821258 1.1517668873166929 24.943068797752993 -10.079363741194411 4.43730203952187 0.9999666737365173 1.4588477172949024 0.42668297915590037 0.2507304480933813 38030195.364906244 43192937.52183127 11201.7369632318 0.08583170304815546 8.329832313929801e-11 10.079363741194411 0.4588810435583851 GGK(ub)PEPPAMPQPVPTA ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GGKPEPPAMPQPVPTA 16 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2 P23396 RPS3 40S ribosomal protein S3 1 316614200.0 118657000.0 55921200.0 142036000.0 True False 153603825.57914773 52809136.06131451 116186905.41243139 1.0 0.3438009168209385 0.7564063263031399 27.19463890663802 -9.267098039420194 13.762156369281623 1.0000000024917268 0.550103621561842 0.6131881021114332 0.1684454530572509 0.0 0.0 0.16309660860877398 0.05436553620292465 5.40632264621082e-10 9.267098039420194 -0.4498963809298848 GGK(ub)TVNELQNLSSAEVVVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGKTVNELQNLSSAEVVVPR 20 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 11547000.0 2548100.0 5705000.0 3293900.0 True False 3340583.775835502 4853836.237915827 2953078.8253198895 1.0 1.4529904243164358 0.8840008284424195 21.6716688088227 -6.694616873525692 1.8496327765085359 1.2827689962313193 0.8858361320001138 0.39207904154239603 0.1914098410317309 0.40693562251897225 2.7025477054877616 0.08267054754642325 0.2140653602369469 2.020147714382872e-07 6.694616873525692 -0.39693286423120555 GGK(ub)TVNELQNLSSAEVVVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGKTVNELQNLSSAEVVVPR 20 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 15946800.0 4730100.0 7348900.0 3867800.0 True False 3933287.728959716 7309310.017057557 4676539.097313376 1.0 1.8583207028667434 1.1889644032093825 21.90730429589485 -10.25293837931966 4.867931355506606 0.9998791100372377 1.5236425530387312 0.4493413325330263 0.27326356504864113 0.0003586056911007387 5.5034371673774266e-05 0.26464689819774473 0.08819543637955934 5.5854943994094244e-11 10.25293837931966 0.5237634430014935 GGKPGLTIQAPQLEVSVPSANIEGLEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGKPGLTIQAPQLEVSVPSANIEGLEGK 28 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9211300.0 3163600.0 4143800.0 1903900.0 False True 4147510.236345977 3525561.1924058897 1706902.69149839 1.0 0.8500427947133811 0.4115487591905737 21.98381411118219 -6.952025055117864 0.5361505618655963 1.0066243481459312 0.23485059590785207 0.9993507731856216 0.006361702186543953 0.08268262065841799 0.032674750093661935 0.007034740086771249 0.03629204782894092 1.1167988160774256e-07 6.952025055117864 -0.7717737522380791 down GGKPGLTIQAPQLEVSVPSANIEGLEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGKPGLTIQAPQLEVSVPSANIEGLEGK 28 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 58530000.0 13382000.0 14417000.0 30731000.0 False True 12957195.734936459 20173783.28366179 22681629.189761564 1.0 1.5569559722916944 1.750504480580249 23.627250180500063 -11.226644386360839 0.19720208472476333 1.6808712189686778e-18 1.9040112029410579 0.9993942626053155 0.007829976368060827 3.521981165466664 0.11348053292520709 1.6773048294580848 0.12367729571021721 5.934110288450991e-12 11.226644386360839 1.9040112029410579 GGKPGLTIQAPQLEVSVPSANIEGLEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGKPGLTIQAPQLEVSVPSANIEGLEGK 28 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 192943000.0 40875000.0 109210000.0 42858000.0 False True 62010363.36277527 89720622.23837543 34387097.514671326 1.0 1.446864965352462 0.5545379135016301 25.886006007496054 -6.770560940476999 1.572458239216413 1.2561262608553811 0.5494299685051547 0.7326549693898192 0.18835826038656725 0.2655196555142852 1.2957882718089715 0.09441687423248524 0.22462196501513945 1.6960515945269073e-07 6.770560940476999 -0.7066962923502265 GGKPGLTIQAPQLEVSVPSANIEGLEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGKPGLTIQAPQLEVSVPSANIEGLEGK 28 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 8006300.0 3163600.0 1613200.0 3229500.0 False True 4333268.413075389 1541923.4898609843 2466758.613640297 1.0 0.3558338286195977 0.569260516195349 22.047024172705083 -10.214706859296312 6.472300912903816 1.0000044430990085 0.46254717240750876 0.8942376787093728 0.08713108034216648 5.5862491883479934e-06 6.778799043321331e-07 0.08436500310821446 0.02812143525852246 6.09948462200959e-11 10.214706859296312 -0.5374572706914997 GGKPGLTIQAPQLEVSVPSANIEGLEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGKPGLTIQAPQLEVSVPSANIEGLEGK 28 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 41628000.0 13382000.0 13532000.0 14714000.0 False True 11127725.923117664 13459100.43010829 17790629.37015071 1.0 1.2095104177707356 1.5987659556918972 23.40765545593434 -6.96145990561223 0.41434526031040586 0.9817100770428554 1.8411147194102546 0.9998205706638665 0.003323183176678494 0.07918366752886283 0.0192343739046942 0.005020102362101405 0.03245570331126353 1.0927985104987408e-07 6.96145990561223 0.8594046423673992 GGKPGLTIQAPQLEVSVPSANIEGLEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGKPGLTIQAPQLEVSVPSANIEGLEGK 28 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 103334000.0 40875000.0 35380000.0 27079000.0 False True 52913493.26670712 33411071.898480482 22150899.85400342 1.0 0.6314282016890113 0.41862478710965473 25.657132329588503 -9.592186683371564 0.12972718316911871 1.6562683814877703 5.803409654298209e-13 0.9998640726852611 0.00280006589164516 1.0573135748549356 0.05281184766129708 0.4562462413532235 0.21081272503678922 2.557486303983401e-10 9.592186683371564 -1.65626838148719 GGLGLILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGLGLILK 8 0 B1AJY7;O75832;B1AJY5 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 32838200.0 9529100.0 8716100.0 14593000.0 False True 12492742.37993568 7415691.855091696 13083056.345940439 1.0 0.5935999982679444 1.0472525525662684 23.574586873235027 -6.670574490505582 1.935711918822857 0.7407228602561523 1.0454098003783463 0.28150265391825635 0.17260719361560825 0.45975570785533193 3.321858946660082 0.0717792671114135 0.19160643757548831 2.135135834586342e-07 6.670574490505582 0.304686940122194 GGLGLILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGLGLILK 8 0 B1AJY7;O75832;B1AJY5 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 32715500.0 11034000.0 4807500.0 16874000.0 False True 10683731.709706236 6727159.820781304 12454193.19085083 1.0 0.6296638668555892 1.165715644051237 23.348912316737085 -6.7208110238478715 1.7561359950146949 0.774894475792631 1.1649344597511944 0.5164925050432296 0.15582291613473764 0.3537277691229944 2.132358692806245 0.07043757930438405 0.17667364863008642 1.9019056830961985e-07 6.7208110238478715 0.3900399839585633 GGLGLILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGLGLILK 8 0 B1AJY7;O75832;B1AJY5 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 18533000.0 6382700.0 7761500.0 4388800.0 False True 9683022.537873654 6376399.684123711 3521351.756320629 1.0 0.6585133577024533 0.3636624558651395 23.207026021757272 -7.445277145663986 0.22888004782351037 1.1532604546864154 1.3297219896316186e-14 0.999926484329281 0.0022294043958079766 0.12332947531526994 0.01982968678794399 0.025273952593820908 0.06052577560204213 3.586929611508448e-08 7.445277145663986 -1.153260454686402 down GGLGLILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGLGLILK 8 0 B1AJY7;O75832;B1AJY5 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 36676600.0 9529100.0 9799500.0 17348000.0 False True 13052265.784244772 9366525.687386997 13250759.693275083 1.0 0.7176168369704219 1.015207620830853 23.63779693475792 -11.049527479466727 11.872988767184056 1.5173755619497118 0.8664122289006374 0.21177834520436634 0.12149092876882193 0.041715276922344925 0.00017401306865325936 0.0029492666810302195 0.03921102865307656 8.922211635689697e-12 11.049527479466727 -0.6509633330490744 GGLGLILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGLGLILK 8 0 B1AJY7;O75832;B1AJY5 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 22424100.0 11034000.0 4604400.0 6785700.0 False True 9175259.889080875 4579595.183298159 8204558.496468115 1.0 0.4991243015086864 0.8942044798351756 23.12931759217136 -9.88638602850367 6.592811576768779 1.0000000138062684 0.6966643906719198 0.44008533042683173 0.16129080739799267 3.2718443499712965e-08 5.471122392850266e-09 0.15616915855492072 0.052056384245724445 1.2990144182458695e-10 9.88638602850367 -0.3033356231343486 GGLGLILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGLGLILK 8 0 B1AJY7;O75832;B1AJY5 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 29121700.0 6382700.0 12568000.0 10171000.0 False True 8262530.9718265785 11868579.75184009 8319982.363272979 1.0 1.436433919861765 1.0069532437024802 22.97815234384972 -10.606227110094062 2.851798645782737 0.9833018425346909 1.2216935819302848 0.26213925360798507 0.17533475544352395 59027352.91926632 58676973.201253094 7361240.663676574 0.0635349544030887 2.4761268524440065e-11 10.606227110094062 0.23839173939559388 GGLGLSGAK(ub)ANYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGLGLSGAKANYR 13 1 P22695;H3BRG4;H3BSJ9 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 1 11523500.0 1178600.0 2484200.0 7860700.0 True False 980058.1208329458 2470817.121524908 9504336.026229706 1.0 2.52109244237982 9.697726924758324 19.902507783002513 -6.9411078574177045 0.6491757059201438 0.9207317957745356 11.697781047845268 0.9983054307922246 0.15613132781160582 0.08726484995192518 0.052335317914627415 0.15328949499596797 0.6147261473324803 1.1452284876196257e-07 6.9411078574177045 10.777049252070732 GGLGLSGAK(ub)ANYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGLGLSGAKANYR 13 1 P22695;H3BRG4;H3BSJ9 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 1 33140280.0 585780.0 4224800.0 28329700.0 True False 758303.757450072 3989686.1661023316 23173985.28726915 1.0 5.261329812631213 30.560293364753587 19.53241634603013 -6.9360594956711 0.6952589219781173 0.6876242363022035 36.65816114959318 0.9976008243431035 0.6390578949329091 0.08961126640258343 0.06314676883875853 0.6048620461912578 2.217850892546186 1.1586186216622485e-07 6.9360594956711 35.97053691329097 GGLVDEK(ub)ALAQALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGLVDEKALAQALK 14 1 Q13363-2;Q13363;H0Y9M9;H0Y8U5;H0Y8W7;P56545;P56545-3;P56545-2 Q13363-2 CTBP1;CTBP2 C-terminal-binding protein 1;C-terminal-binding protein 2 1 8383400.0 2768200.0 1309200.0 4306000.0 True False 2680325.0062360694 1831970.3873878072 3178129.4227689756 1.0 0.6834881527895041 1.1857253935156034 21.353976516446128 -6.736358439407988 1.6998798591141489 0.8108864830035101 1.1858002713905018 0.5885286670082481 0.1330015906449123 0.3244551542545313 1.839377690254967 0.06193168037664859 0.15259526925311698 1.8350232052013193e-07 6.736358439407988 0.37491378838699174 GGLVDEK(ub)ALAQALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGLVDEKALAQALK 14 1 Q13363-2;Q13363;H0Y9M9;H0Y8U5;H0Y8W7;P56545;P56545-3;P56545-2 Q13363-2 CTBP1;CTBP2 C-terminal-binding protein 1;C-terminal-binding protein 2 1 6487400.0 2768200.0 1542700.0 2176500.0 True False 2301880.9520530785 1534389.1688980255 2631596.0870010224 1.0 0.6665805925060908 1.1432372663120856 21.134381791880404 -6.718605738005082 1.7639228377587886 0.7968609702175096 1.1424593000383474 0.506176921391555 0.14032766547420455 0.35800197591775523 2.1760719951244045 0.06318054918913295 0.15889204821372116 1.9115878522061543e-07 6.718605738005082 0.3455983298208378 GGMALALAVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGMALALAVTK 11 0 P10155-3;P10155-5;P10155-4;P10155;H0Y9N5;P10155-2 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 0 25372000.0 5447300.0 9927600.0 9997100.0 False True 8263952.350973589 8155942.2153071705 8021168.803115418 1.0 0.9869299663067764 0.9706213761228223 22.97840050513263 -6.968142144133235 0.2993868400418473 1.002849156330928 0.9541917182901481 0.9999637398570617 7.213763866758903e-05 0.07691148306557664 0.011183817724880356 0.00027138991596242356 0.0014635817700672815 1.0761129453341902e-07 6.968142144133235 -0.04865743804077993 GGMALALAVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGMALALAVTK 11 0 P10155-3;P10155-5;P10155-4;P10155;H0Y9N5;P10155-2 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 0 26449300.0 5447300.0 13623000.0 7379000.0 False True 7051637.2323359875 12864868.074420553 6036097.714933769 1.0 1.824380303545312 0.8559852862615563 22.74952682722508 -6.681217548812756 1.8976927481784143 1.5210254263518126 0.8596464187201073 0.32966931426786705 0.3492993253690918 0.43581109551913005 3.035474953159935 0.14764380696141746 0.38877556188848045 2.0834469717067723e-07 6.681217548812756 -0.6613790076317053 GGMGSGGLATGIAGGLAGMGGIQNEK(ub)ETMQSLNDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGMGSGGLATGIAGGLAGMGGIQNEKETMQSLNDR 35 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 64296000.0 6329000.0 10528000.0 47439000.0 True False 6128089.359319447 14731885.302794728 35013302.760505624 1.0 2.4039932251299243 5.713575750532792 22.547005904006607 -6.956708757323174 0.4795723071424669 0.9202400869755382 7.3352146594634 0.9996279902532254 0.03811282799393566 0.08089843847337326 0.025639593984012922 0.04662375720042333 0.27301677376000194 1.1048192755385147e-07 6.956708757323174 6.4149745724878615 GGMGSGGLATGIAGGLAGMGGIQNEK(ub)ETMQSLNDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGMGSGGLATGIAGGLAGMGGIQNEKETMQSLNDR 35 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 312220000.0 7111000.0 49909000.0 255200000.0 True False 10787906.883735664 41002349.00920316 204759608.1418665 1.0 3.8007696442968144 18.980476041239413 23.362911638269534 -6.938023843121577 0.6776985911325122 0.822383872290521 22.846467375973443 0.997893437110783 0.36254848769145925 0.08867987365764624 0.05880256982127244 0.3478377538226834 1.3182669561917661 1.1533899340339372e-07 6.938023843121577 22.024083503682924 GGMGSGGLATGIAGGLAGMGGIQNEK(ub)ETMQSLNDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGMGSGGLATGIAGGLAGMGGIQNEKETMQSLNDR 35 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 45597700.0 6329000.0 9851700.0 29417000.0 True False 5262843.9222397 9798626.93669066 35567958.691159695 1.0 1.8618501862241572 6.758315317096292 22.327411179440883 -6.93700061582412 0.6868990992311008 0.9411559593002217 7.969841903114653 0.9977440769422856 0.12044574447109578 0.08916199096291588 0.06104271080311664 0.11473410465036164 0.42729469145792104 1.1561106028406242e-07 6.93700061582412 7.028685943814431 GGMGSGGLATGIAGGLAGMGGIQNEK(ub)ETMQSLNDR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GGMGSGGLATGIAGGLAGMGGIQNEKETMQSLNDR 35 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 377502100.0 12151100.0 64101000.0 301250000.0 True False 15729838.48398985 60533723.000692375 246425591.08602753 1.0 3.848337226240742 15.666123421219138 23.907000521262454 -6.944035975414889 0.6208913664429638 0.8707336700533488 19.270759547584646 0.9986460727144694 0.23364199913146122 0.08597294416480815 0.04658247160931347 0.235104160037564 1.0004779526132808 1.1375330527160794e-07 6.944035975414889 18.4000258775313 GGNFGFGDSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGNFGFGDSR 10 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 114411900.0 9479900.0 56551000.0 48381000.0 False True 12428240.703482203 48113811.234071545 43374998.223322414 1.0 3.8713292075676318 3.490035255848352 23.567118752396198 -9.817855108153372 6.271083772069991 0.9999998998290003 3.6806822317092096 0.9850531359923282 0.15566260395796438 52663861.64920895 4.284510908325733 78.65242133409656 0.05328744971667623 1.521054908260458e-10 9.817855108153372 2.6806823318802095 GGNFGFGDSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGNFGFGDSR 10 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 72027400.0 27980000.0 6868400.0 37179000.0 False True 27091790.215477664 9610987.938232834 27440704.55390793 1.0 0.3547564727834793 1.0128789694462839 24.691352393656107 -10.888598542766458 12.193174001552373 1.0138547972022092 0.6838177211148816 0.23532878640237298 0.26867738417839937 0.09175316115920487 0.0008382898230155344 0.2358780341665918 0.08671525286879268 1.2924134149174068e-11 10.888598542766458 -0.3300370760873276 GGNFGFGDSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGNFGFGDSR 10 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 281504200.0 10479000.0 266060000.0 4965200.0 False True 15897409.117517365 218579514.26373202 3983826.0436755354 1.0 13.74937970382099 0.2505959313386327 23.922288325451905 -6.659108641917798 1.9761613263275197 9.212919505526829 0.30738306434868223 0.23166060235229147 5.4296219457450405 0.4866556780619956 3.652517870020839 2.2205803488408353 6.017995431420715 2.1922564578809104e-07 6.659108641917798 -8.905536441178146 GGNFGFGDSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGNFGFGDSR 10 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 76659900.0 9479900.0 30045000.0 37135000.0 False True 12984875.214664767 28717512.554471374 28364477.819331925 1.0 2.2116125168487253 2.184424366843191 23.63032881391909 -10.265738784452752 5.692001919946682 0.9999207511518725 2.198018441845924 0.9996138767391755 0.011099515760697976 1.1164680023201546e-05 1.440215434854039e-06 0.010747759059644044 0.0035823533076699 5.4232698629159005e-11 10.265738784452752 1.1980976906940515 GGNFGFGDSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGNFGFGDSR 10 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 35698000.0 27980000.0 4829100.0 2888900.0 False True 23266609.7241692 4803084.679798704 3492955.6332355873 1.0 0.20643680951975102 0.15012740036667777 24.471757669090383 -13.702303390241234 0.37829659782965747 9.999302574250013 0.14496327649666088 0.9997977927618502 0.005517953389288557 18.884407615617658 0.19994083557051756 137.02391895876323 0.015346771374415962 1.9847079520128462e-14 13.702303390241234 -9.854339297753352 GGNGLAPGEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGNGLAPGEDR 11 0 E9PBY3;Q86SF2 E9PBY3 GALNT7 N-acetylgalactosaminyltransferase 7 0 11072700.0 2384600.0 2798000.0 5890100.0 False True 2308902.178264047 3915255.991377244 4347306.110787626 1.0 1.6957219011854965 1.8828455149434515 21.138775620771895 -11.050685907501286 0.2497191611488001 1.7169818037264807e-10 1.9733348999195277 0.9992421381160272 0.010456541576913466 3.060723875674535 0.13351547806979547 1.833168729216492 0.08578007870070802 8.898444426805783e-12 11.050685907501286 1.9733348997478295 GGNGLAPGEDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGNGLAPGEDR 11 0 E9PBY3;Q86SF2 E9PBY3 GALNT7 N-acetylgalactosaminyltransferase 7 0 12329300.0 3178700.0 5168000.0 3982600.0 False True 4114889.8115445087 4880396.256962895 3257807.6649268446 1.0 1.186033279255917 0.7917120054556306 21.972422368022908 -6.778403730056231 1.5419485895196812 1.1055558879127907 0.7887359965074073 0.7617343406690968 0.07862048929937225 0.2530702982895308 1.1883434663402694 0.04016231877610782 0.09489902697964801 1.665698021707053e-07 6.778403730056231 -0.31681989140538336 GGNIGDGGGAADR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGNIGDGGGAADR 13 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 4350790.0 1284600.0 601290.0 2464900.0 False True 1243821.0761544884 841388.2326859266 1819268.7445850545 1.0 0.6764543942986075 1.4626450535873479 20.246347537823294 -6.794950660381184 1.4764292822254237 0.820327607986594 1.472193205618649 0.8169889317723057 0.13802095447222806 0.22804687760049722 0.9818466179260792 0.07356169922059713 0.17163096788371685 1.603427543614693e-07 6.794950660381184 0.6518655976320551 GGNK(ub)MIIEEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGNKMIIEEAK 11 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 10399000.0 3099900.0 2655000.0 4644100.0 True False 3001495.3712994717 3715155.34564209 3427670.8899863893 1.0 1.2377681408962644 1.1419877314361504 21.517250012465247 -10.191022386729164 4.504035949528031 0.9999568669702327 1.189877936169295 0.8397445399444771 0.039102188432517095 1.6940047387760898e-05 3.042516624693102e-06 0.0378691238370583 0.01262017704847591 6.441360611531318e-11 10.191022386729164 0.18992106919906238 GGNK(ub)MIIEEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGNKMIIEEAK 11 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 8856800.0 3363600.0 2263200.0 3230000.0 True False 5102827.112098612 1859314.277537693 2591589.084240709 1.0 0.36436944397534626 0.5078731901569129 22.28286533220217 -10.076539653652972 7.604381129839402 1.000000053560079 0.43612131706751334 0.9536748615170006 0.05858515905378474 5.3182810250082315e-08 6.446998354841809e-09 0.05672484140910039 0.018908278779185096 8.384175226518071e-11 10.076539653652972 -0.5638787364925657 GGNK(ub)MIIEEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGNKMIIEEAK 11 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 9141000.0 3099900.0 4479400.0 1561700.0 True False 2577704.1988546136 4455268.5831087185 1888244.2495150445 1.0 1.7283862846203955 0.7325294540599631 21.297655287899524 -6.710659107680822 1.7931684166100903 1.4474988955853758 0.7348542330198509 0.4681179538176159 0.306906269714442 0.3737377450720833 2.343055155932175 0.1361909715096206 0.3456723059907954 1.946887659506394e-07 6.710659107680822 -0.712644662565525 GGNK(ub)MIIEEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGNKMIIEEAK 11 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 5556700.0 3363600.0 2193100.0 0.0 True False 4354246.506468403 2071052.057110162 0.0 1.0 0.4756395978118219 0.0 22.05399165429462 -8.00638205869471 0.5783171083486426 1.0146770214583976 1.143813490116526e-16 0.9896240390175397 0.04160162386406561 0.11188432668031324 0.1650012899303359 0.046426597372678235 0.07611137477596434 9.854122147583025e-09 8.00638205869471 -1.0146770214583973 GGNLCSGGASTAGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGNLCSGGASTAGKR 15 1 Q6ZT12;Q6ZT12-4;H7BZD8;H0Y3K2;Q6ZT12-2 Q6ZT12 UBR3 E3 ubiquitin-protein ligase UBR3 1 3346250.0 1512600.0 1176700.0 656950.0 True False 1464583.3409553778 1646562.446409436 484875.08692245214 1.0 1.124253158127109 0.331066913956674 20.482058860296323 -6.8668659404181955 1.1506199253567166 1.0690959077209596 0.2873133928426596 0.9614499117971227 0.06839331206466531 0.13989128190998545 0.34812530755249543 0.04621480856764049 0.10885271167519642 1.358732800384978e-07 6.8668659404181955 -0.7817825148783 down GGNRFEPYANPTK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGNRFEPYANPTKR 14 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 24824300.0 3826900.0 4567400.0 16430000.0 True False 4953997.489476733 4313220.174932718 13439908.58603629 1.0 0.8706544934862902 2.712942147141839 22.24016170679816 -6.890051115420948 1.0220472240614036 0.901133389566881 2.871574366052076 0.9809321602238704 0.11594251942511245 0.11910299476541518 0.22158926172557347 0.08642831041296736 0.21551369988520314 1.2880979367271207e-07 6.890051115420948 1.970440976485195 up GGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPR 38 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 109557200.0 62270000.0 38064100.0 9223100.0 False True 81636573.02353777 32385084.652699687 8268782.08622237 1.0 0.39669823772933605 0.10128771676682562 26.282712285757594 -8.848791798168623 0.3288280841877506 1.1952135885039727 2.134900773510266e-18 0.9982253832370707 0.015755449211258443 0.3661565444259863 0.11039473548865608 0.1780285435177762 0.08764017192110447 1.416472677659794e-09 8.848791798168623 -1.1952135885039727 GGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPR 38 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 345460000.0 128542300.0 81379700.0 135538000.0 False True 124461795.04699752 113875038.59952913 100036531.74715771 1.0 0.9149397094628857 0.8037529244165514 26.891127717818524 -6.967444066002473 0.3133016772900615 1.016474924349625 0.6986665366588856 0.99995500717649 0.0005389560981937952 0.07714126847931228 0.011985621946948173 0.0017335777465194108 0.009840179159817997 1.0778440632981999e-07 6.967444066002473 -0.3178083876907394 GGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPR 38 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 1606961000.0 384116000.0 519817000.0 703028000.0 False True 582732054.6411206 427051595.00124115 564074207.651881 1.0 0.7328438372319226 0.9679821165823285 29.118257431033225 -10.233938322350756 7.108991030513897 1.000000535757607 0.8504129770979713 0.3504848173347397 0.09599480056741745 8.151972382508263e-07 8.78668701025648e-08 0.0929468997617151 0.030982188660009166 5.835279698854705e-11 10.233938322350756 -0.1495875586596357 GGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPR 38 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 171829400.0 62270000.0 17169000.0 92390400.0 False True 85292901.78347597 16410416.80970942 70569690.36001627 1.0 0.19240073284607906 0.8273805778019377 26.345922347280485 -10.466888639804546 8.328332868040688 1.000017797709742 0.5098906553306154 0.4426911053108019 0.2592294361822381 8.56691635502306e-05 5.483768909037979e-06 0.2510069078909972 0.08366594076504555 3.412804102723473e-11 10.466888639804546 -0.4901271423791266 GGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPR 38 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 393267000.0 128542300.0 81109700.0 183615000.0 False True 106888617.83942354 80672745.94708519 222008047.56016192 1.0 0.7547365433078956 2.077003632825338 26.6715329932528 -6.858809376158829 1.191864476169247 0.8673366395871185 2.13954953169293 0.9521551928198049 0.12562130590136297 0.148042607847924 0.4003099935627486 0.08224744602319338 0.19172404670114693 1.3841737977594527e-07 6.858809376158829 1.2722128921058113 up GGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGNVGINSFGFGGSNVHIILRPNTQPPPAPAPHATLPR 38 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 1109812000.0 384116000.0 359248000.0 366448000.0 False True 497245734.0583361 339255532.99562746 299758224.07400036 1.0 0.6822693685609911 0.6028371960629696 28.889383753125674 -13.999999999999998 0.19468242718633624 2.731688788222616 0.5484607102190382 0.9994875078411555 0.003884590457649154 12.430744101186367 0.13992147334601637 8.1795106065495 0.05265960111742301 1.0000000000000041e-14 13.999999999999998 -2.183228078003578 GGPGGGFRPFVPHIPFDFYLCEMAFPR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GGPGGGFRPFVPHIPFDFYLCEMAFPR 27 1 Q12905;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 1419640000.0 470523000.0 421767000.0 527350000.0 False True 713817790.8389744 346499383.5693884 423119041.35428375 1.0 0.4854171302765316 0.5927549674223972 29.410980617946336 -10.568408280456985 5.74325037951061 1.0015306663917685 0.5390860488495433 0.9609148183925241 0.043820488516888474 0.0008613477305158594 6.472823834648307e-05 0.0425524015342726 0.014143001854048478 2.7014175660048516e-11 10.568408280456985 -0.4624446175422252 GGPGGGFRPFVPHIPFDFYLCEMAFPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGPGGGFRPFVPHIPFDFYLCEMAFPR 27 1 Q12905;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 943640000.0 441390000.0 163120000.0 339130000.0 False True 571388056.0976595 154042228.6059958 277411819.76765 1.0 0.26959301469834623 0.4855051077935655 29.089895638584995 -10.201309874149866 5.111066191606117 1.0000515164836072 0.37754906124629706 0.9172282093108466 0.08814574289802338 5.174848594566288e-05 8.086559726572156e-06 0.08535377943354498 0.028448916190055774 6.29057183096917e-11 10.201309874149866 -0.6225024552373102 GGPNIITLADIVKDPVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGPNIITLADIVKDPVSR 18 1 P68400;Q8NEV1;E7EU96;A0A2R8YD58;A0A2R8Y5A0;A0A2R8YF43;A0A2R8Y4D6;A0A2R8Y4H0;V9GYA2;A0A2R8YEW1 P68400 CSNK2A1;CSNK2A3 Casein kinase II subunit alpha;Casein kinase II subunit alpha 3 0 6806790.0 374490.0 4521200.0 1911100.0 False True 490960.01656631846 3846654.5834995653 1713357.7045656643 1.0 7.834965075979792 3.489811077791149 18.905246011705305 -9.515613277166981 10.31642746626031 1.000024463454265 5.662388076885461 0.6055429497952327 1.7739016916189612 0.0 0.0 1.7175728761505358 0.5725243091123144 3.050610233730308e-10 9.515613277166981 4.662363613431196 GGPNIITLADIVKDPVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGPNIITLADIVKDPVSR 18 1 P68400;Q8NEV1;E7EU96;A0A2R8YD58;A0A2R8Y5A0;A0A2R8YF43;A0A2R8Y4D6;A0A2R8Y4H0;V9GYA2;A0A2R8YEW1 P68400 CSNK2A1;CSNK2A3 Casein kinase II subunit alpha;Casein kinase II subunit alpha 3 0 9552690.0 374490.0 5632100.0 3546100.0 False True 512949.07321172167 5383255.199135902 2708584.2142219725 1.0 10.494716688792892 5.280415455793199 18.968456073228197 -9.736624950337783 7.8591391359794285 0.9999999992225972 7.887566072293063 0.6993716346941004 2.1287295643358006 3.785289037305275e-08 0.0 2.0611335378129523 0.6870445126043175 1.8338974627976863e-10 9.736624950337783 6.887566073070466 GGPNYQEGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGPNYQEGLR 10 0 P53396;P53396-2;P53396-3;K7EIE7 P53396 ACLY ATP-citrate synthase 0 6890820.0 1818300.0 598920.0 4473600.0 False True 1760579.0617870993 838071.8793265393 3301829.954876748 1.0 0.47602058749684506 1.8754227098016156 20.74761858464624 -6.805297642497602 1.4342603463656256 0.712810030808687 1.897347066683524 0.8471797469359241 0.2256707233236095 0.21328336459209238 0.865565797572398 0.12375266821644564 0.28691610770966475 1.565677669551626e-07 6.805297642497602 1.184537035874837 GGPPFAFVEFEDPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGPPFAFVEFEDPR 14 0 J3KTL2;Q07955;Q07955-3;Q07955-2;J3QQV5;J3KSW7 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 22695500.0 5240500.0 7547500.0 9907500.0 False True 6870346.2490741825 6421442.41992458 8882366.93945074 1.0 0.9346606687821454 1.292855791751062 22.7119513785909 -6.859656576955478 1.1874622514530306 0.9645810108023447 1.310088335448647 0.9532204269821295 0.03368767368904696 0.14715872508018618 0.3944903488898275 0.02212971969194567 0.05163782077273171 1.3814762500374006e-07 6.859656576955478 0.3455073246463023 GGPPFAFVEFEDPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGPPFAFVEFEDPR 14 0 J3KTL2;Q07955;Q07955-3;Q07955-2;J3QQV5;J3KSW7 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 20362300.0 7143300.0 3257300.0 9961700.0 False True 6916539.851544741 4557956.876595097 7352431.925405874 1.0 0.6589937995625258 1.06302169628413 22.72161904830299 -6.68297775890615 1.891511114590731 0.7848189508419754 1.0615141496135225 0.33773371520722995 0.144433573453954 0.4319300329213926 2.9903733515278965 0.06121692243924291 0.16083016949084095 2.0750197806700579e-07 6.68297775890615 0.27669519877154714 GGPPFAFVEFEDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGPPFAFVEFEDPR 14 0 J3KTL2;Q07955;Q07955-3;Q07955-2;J3QQV5;J3KSW7 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 19102000.0 5240500.0 6849900.0 7011600.0 False True 7178054.469187497 6547248.768409838 5355604.4884348335 1.0 0.9121202404515799 0.7461080870066243 22.77516144011379 -6.961145351861461 0.4189816956379028 1.0074189729937215 0.6445574275516147 0.9998103395866432 0.0014497964058372446 0.07929452108242513 0.019638318848869483 0.0021461573467430168 0.01382316821077312 1.0935902967158603e-07 6.961145351861461 -0.3628615454421068 GGPPFAFVEFEDPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGPPFAFVEFEDPR 14 0 J3KTL2;Q07955;Q07955-3;Q07955-2;J3QQV5;J3KSW7 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 12739100.0 7143300.0 2997100.0 2598700.0 False True 5939970.451846248 2980954.0274222256 3142076.1549687823 1.0 0.5018466087648117 0.5289716809941655 22.502024323737267 -10.678161405895578 6.662241907791178 1.0034770316517798 0.5154091448794903 0.9976555908893234 0.01107376436634249 0.0005743752342086177 2.7746797744312694e-05 0.010768381892882253 0.0035740420808891256 2.0981599558569377e-11 10.678161405895578 -0.4880678867722895 GGPSPLK(ub)SNSDSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGPSPLKSNSDSAR 14 1 A0A5F9ZH94;Q9Y653-5;Q9Y653-4;Q9Y653-2;Q9Y653-3;Q9Y653 A0A5F9ZH94 GPR56 G-protein coupled receptor 56;GPR56 N-terminal fragment;GPR56 C-terminal fragment 1 2459430.0 546340.0 792590.0 1120500.0 True False 528996.7357513963 1109075.3203022461 827007.4357205365 1.0 2.0965636370645955 1.5633507351341982 19.012899294451344 -10.099202875425402 5.602027177686861 0.9999925395625321 1.8299571860995638 0.7636126228149578 0.21768325566694927 2.028300448409568e-05 3.2618733461589167e-06 0.2107728010036656 0.0702569686621065 7.957875210407685e-11 10.099202875425402 0.8299646465370317 GGPSPLK(ub)SNSDSAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGPSPLKSNSDSAR 14 1 A0A5F9ZH94;Q9Y653-5;Q9Y653-4;Q9Y653-2;Q9Y653-3;Q9Y653 A0A5F9ZH94 GPR56 G-protein coupled receptor 56;GPR56 N-terminal fragment;GPR56 C-terminal fragment 1 2713620.0 605670.0 568350.0 1539600.0 True False 829602.5666163146 543238.4177178842 1175978.1890573176 1.0 0.654817667613519 1.4175199503706446 19.662060831990676 -6.7836580971010605 1.521556206620634 0.8054779450234565 1.4242761738343852 0.780141344472076 0.14621816725321327 0.24493127758094804 1.1202044315828876 0.07567061619470726 0.17801749396729616 1.6456667818574907e-07 6.7836580971010605 0.6187982288109287 GGPSPLK(ub)SNSDSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGPSPLKSNSDSAR 14 1 A0A5F9ZH94;Q9Y653-5;Q9Y653-4;Q9Y653-2;Q9Y653-3;Q9Y653 A0A5F9ZH94 GPR56 G-protein coupled receptor 56;GPR56 N-terminal fragment;GPR56 C-terminal fragment 1 2303550.0 546340.0 796950.0 960260.0 True False 454305.91696578264 792656.6721678097 1161045.9262594085 1.0 1.744764139243009 2.555647819895896 18.79330456988562 -6.970036176628 0.2573239931990063 0.7647754810831038 3.559610474876206 0.9999826624471134 0.002645204444279013 0.07629101445085106 0.008988298797225106 0.01722450860962528 0.07681932946310276 1.0714300516494401e-07 6.970036176628 2.7948349937931023 GGQGAK(ub)K(ub)SAIGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGQGAKKSAIGQR 13 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 2 9291500.0 1394600.0 5368600.0 2528300.0 True False 1828334.10532561 4567625.806638893 2266695.7691661227 1.0 2.4982446005542513 1.2397601524599053 20.802098298392394 -6.603453697450105 2.178661977052007 2.0053619386360113 1.2440555104355195 0.030424986393986386 0.6470250959471753 0.6308318372100374 5.664441820729505 0.24612215567535442 0.7188868322236922 2.4919900420080533e-07 6.603453697450105 -0.7613064282004918 GGQGAK(ub)K(ub)SAIGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGQGAKKSAIGQR 13 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 2 7561600.0 1758200.0 3091700.0 2711700.0 True False 1702386.9033900232 4326231.933002514 2001424.42074376 1.0 2.5412742099857177 1.1756577877556817 20.699127526540632 -6.617034585094279 2.12746003805093 2.024789326729158 1.1807637180205999 0.07294546970050719 0.6633014064050813 0.5934442353859771 5.099626834023692 0.2565424185524235 0.7357968506215595 2.4152684865843547e-07 6.617034585094279 -0.8440256087085583 GGQGAK(ub)K(ub)SAIGQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGQGAKKSAIGQR 13 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 2 5045430.0 1758200.0 2445400.0 841830.0 True False 1462021.201466558 2432226.144826106 1017852.7608178601 1.0 1.6636052489432658 0.6961956227425764 20.47953280197491 -6.722104635910498 1.7517278309076485 1.4028338863884273 0.6975298043567076 0.5223354419578996 0.27918024501176825 0.35129790001131955 2.1078204537353162 0.1264890718450407 0.3167532627067381 1.8962489970433655e-07 6.722104635910498 -0.7053040820317197 GGQIGLQAPGLSVSGPQGHLESGSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGQIGLQAPGLSVSGPQGHLESGSGK 26 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 92083000.0 28588000.0 34878000.0 28617000.0 False True 37479144.846585855 29674338.353379205 25655987.353647456 1.0 0.7917560145741259 0.6845403612773352 25.159584699928367 -13.999999929427737 0.08469355603683694 2.093636728964406 0.39042193627464483 0.9998665978333783 0.0015126772148906392 12.212866728578627 0.08321516869271285 2.4524606026196047 0.26565507326987803 1.0000001624986533e-14 13.999999929427737 -1.703214792689761 GGQIGLQAPGLSVSGPQGHLESGSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGQIGLQAPGLSVSGPQGHLESGSGK 26 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 82982000.0 25267000.0 15030000.0 42685000.0 False True 24464912.915456545 21031557.380414546 31504517.977448557 1.0 0.8596620577842785 1.2877429029205536 24.544210811619212 -6.818388338686748 1.3786908304505916 0.9242285617585628 1.2967784239739257 0.8806418864731641 0.06155923589545783 0.19560286672468621 0.7309762442721865 0.03508969705611739 0.08091852207687776 1.5191884898822884e-07 6.818388338686748 0.3725498622153629 GGQIGLQAPGLSVSGPQGHLESGSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGQIGLQAPGLSVSGPQGHLESGSGK 26 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 127573000.0 21832000.0 77720000.0 28021000.0 False True 33120740.132993516 63850258.77086837 22482637.06795941 1.0 1.9278028967493808 0.678808413630924 24.981231576610025 -6.707785230386324 1.803271847832675 1.5716747733569185 0.681944466528176 0.45455469686197514 0.3911077277169932 0.3795137472770461 2.4043010541985663 0.1726955714702746 0.4398819552484934 1.9598136113395146e-07 6.707785230386324 -0.8897303068287425 GGQIGLQAPGLSVSGPQGHLESGSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGQIGLQAPGLSVSGPQGHLESGSGK 26 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 97936000.0 28588000.0 35427000.0 33921000.0 False True 39157756.161651105 33861717.998577416 25909558.424924176 1.0 0.8647512349479225 0.6616711723206075 25.222794761451258 -6.965240279086888 0.35390439890471254 1.0187642890199005 0.5007641727967805 0.9999180114114483 0.0012589998489445115 0.07787951780761192 0.014572977750517009 0.002761137286364519 0.017411029609901485 1.083327383182104e-07 6.965240279086888 -0.5180001162231199 GGQIGLQAPGLSVSGPQGHLESGSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGQIGLQAPGLSVSGPQGHLESGSGK 26 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 53598000.0 25267000.0 14538000.0 13793000.0 False True 21010630.017890748 14459680.908432929 16677052.5283736 1.0 0.6882078688797231 0.7937435723808822 24.32461608705349 -10.849644938272618 10.458879306710848 1.00693098613977 0.7409757206303027 0.8892819066795191 0.043084770537249344 0.006955908603048215 9.999676329305937e-05 0.041673233279182764 0.013905549897161211 1.4136928507941372e-11 10.849644938272618 -0.26595526550946724 GGQIGLQAPGLSVSGPQGHLESGSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGQIGLQAPGLSVSGPQGHLESGSGK 26 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 85149000.0 21832000.0 44542000.0 18775000.0 False True 28261954.373058107 42063198.54443516 15358142.647768192 1.0 1.4883329719240388 0.5434211111178138 24.752357898702474 -6.7662209465820995 1.588740930197944 1.2814395546394561 0.5388253398839143 0.715980462466469 0.20562291447789427 0.27257523939673706 1.357165985353555 0.10204890702562776 0.243788240637291 1.713085556400929e-07 6.7662209465820995 -0.7426142147555418 GGQLLVSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGQLLVSLK 9 0 Q8TED0;H0Y8P4;Q8TED0-3;Q8TED0-2 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 0 6031700.0 2109400.0 1526300.0 2396000.0 False True 2765443.8274586597 1298581.9894708015 2148084.9040549104 1.0 0.46957453142852307 0.7767595503933706 21.399079607212446 -10.240445056869246 5.737507695433366 1.0000165270959835 0.623167040910946 0.6673859316492508 0.12540775884852984 2.6513382472032227e-05 3.50995128555455e-06 0.12143085965436104 0.04047518012545953 5.7485053929644464e-11 10.240445056869246 -0.37684948618503755 GGQLLVSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGQLLVSLK 9 0 Q8TED0;H0Y8P4;Q8TED0-3;Q8TED0-2 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 0 8353300.0 1652000.0 3257700.0 3443600.0 False True 2506204.777377487 2676337.9824737264 2762970.9506164994 1.0 1.0678847980148964 1.1024521920781327 21.25707286875533 -13.99999999999968 0.08670993547537842 0.6470923916635064 1.193988764903217 0.9998575599582729 0.0005078746896619925 12.194132335174487 0.0847377422578605 0.802676084518148 0.08250551098911064 1.0000000000007362e-14 13.99999999999968 0.5468963732397106 GGQLLVSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGQLLVSLK 9 0 Q8TED0;H0Y8P4;Q8TED0-3;Q8TED0-2 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 0 5318000.0 2109400.0 1374400.0 1834200.0 False True 2889302.184391591 1313674.463466984 1400999.7365347673 1.0 0.454668421518398 0.4848920767454374 21.462289668735338 -9.939052790199899 5.16436487889186 1.000001547653102 0.4697802491581479 0.9975689915338618 0.012338755599573722 16903947.78900857 2.81419911525814 353.61629785514776 0.00422388423010018 1.150660513138971e-10 9.939052790199899 -0.5302212984949539 GGQLLVSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGQLLVSLK 9 0 Q8TED0;H0Y8P4;Q8TED0-3;Q8TED0-2 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 0 5926500.0 1652000.0 1964400.0 2310100.0 False True 2138546.565788384 1855079.4131536188 1889685.503627657 1.0 0.8674486882027449 0.8836307489666546 21.02819919084778 -9.918848051983845 5.157272866175931 1.0000003305484948 0.8755397186030183 0.9874802370335279 0.006606298649504039 2.5109868047410954e-08 5.2673358062814404e-09 0.006396538125730992 0.0021321737198721413 1.205457623960445e-10 9.918848051983845 -0.12446061194547653 GGSASVWSER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGSASVWSER 10 0 Q8IZ83-3;Q8IZ83;F5H4B6 Q8IZ83-3 ALDH16A1 Aldehyde dehydrogenase family 16 member A1 0 4041500.0 1528100.0 2513400.0 0.0 False True 2003353.8981414514 2138410.517156467 0.0 1.0 1.067415257554 0.0 20.933985869153993 -6.978299227729945 1.1559962660780165 1.0457544889331019 6.105117403488569e-22 0.9793867875464338 0.07007383504498937 0.0975597804191367 0.25698310581914224 0.05083061849743106 0.09453728888733343 1.0512373245564457e-07 6.978299227729945 -1.0457544889331019 down GGSASVWSER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGSASVWSER 10 0 Q8IZ83-3;Q8IZ83;F5H4B6 Q8IZ83-3 ALDH16A1 Aldehyde dehydrogenase family 16 member A1 0 7296400.0 1528100.0 2866700.0 2901600.0 False True 2093079.865349763 2740039.715090804 2216301.8403278165 1.0 1.3090946793054792 1.058871129104031 20.997195930676885 -10.765607842855653 8.247328830901614 0.997853809468028 1.183982904204755 0.41888757207454896 0.10215333660353985 0.004071502707592554 0.00011571342914477322 0.09989800293387104 0.03296984761875253 1.7155056674019354e-11 10.765607842855653 0.1861290947367269 GGSCSQAASSNSAQGSDESLIACK(ub)A ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGSCSQAASSNSAQGSDESLIACKA 25 1 O78179;A0A140T912;Q53YP1;A0A140T9M0;Q5QT33;A0A140T9J9 O78179;Q53YP1;Q5QT33 HLA-C 1 27050400.0 8336500.0 9876100.0 8837800.0 True False 10929232.230780834 8402624.376736281 7923349.234163796 1.0 0.7688211028283695 0.7249685125958492 23.38168872068795 -13.999999999999998 0.23375249361576658 2.485165933584284 0.7043942657759504 0.9995151399629123 0.0026566636048562992 13.411076784085243 0.1530584901595872 9.263896427106948 0.022243824790426785 1.0000000000000041e-14 13.999999999999998 -1.7807716678083336 GGSCSQAASSNSAQGSDESLIACK(ub)A ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGSCSQAASSNSAQGSDESLIACKA 25 1 O78179;A0A140T912;Q53YP1;A0A140T9M0;Q5QT33;A0A140T9J9 O78179;Q53YP1;Q5QT33 HLA-C 1 27444500.0 9122100.0 6103400.0 12219000.0 True False 13838892.614839684 5014200.583918146 9803909.294222057 1.0 0.36232672103700925 0.7084316330129735 23.722225167663197 -10.654937892910805 6.801734229734423 1.0020896710425795 0.5353791770251216 0.7061257663741056 0.1412967386353332 0.00449277704835481 0.00022792491477726247 0.13727803178760412 0.0456033263006723 2.2134112199569958e-11 10.654937892910805 -0.4667104940174579 GGSCSQAASSNSAQGSDESLIACK(ub)A ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGSCSQAASSNSAQGSDESLIACKA 25 1 O78179;A0A140T912;Q53YP1;A0A140T9M0;Q5QT33;A0A140T9J9 O78179;Q53YP1;Q5QT33 HLA-C 1 23183600.0 8336500.0 7018800.0 7828300.0 True False 11418729.335441584 6708686.207932235 5979416.768899319 1.0 0.5875160020747437 0.5236499257706666 23.444898782210842 -13.999999999999998 0.26260106589128335 4.060973020213776 0.5008823644683807 0.9995676857764133 0.0043895643190026215 14.533642673614615 0.16217219481878228 23.64460193310431 0.027543970599016896 1.0000000000000041e-14 13.999999999999998 -3.5600906557453955 GGSCSQAASSNSAQGSDESLIACK(ub)A ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGSCSQAASSNSAQGSDESLIACKA 25 1 O78179;A0A140T912;Q53YP1;A0A140T9M0;Q5QT33;A0A140T9J9 O78179;Q53YP1;Q5QT33 HLA-C 1 27114800.0 9122100.0 5010700.0 12982000.0 True False 11808738.273473488 4731850.140240703 10619409.206568656 1.0 0.40070751257736614 0.8992839845069243 23.493351489755646 -10.16678508287697 7.662457317382025 1.0000001444107682 0.6499957485421576 0.3965307992701004 0.2035429923307463 5.02028526660948e-07 5.442300808305389e-08 0.19707973711032098 0.065693218294517 6.811063309687412e-11 10.16678508287697 -0.35000439586861065 GGSDDSSK(ub)DPIDVNYEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGSDDSSKDPIDVNYEK 17 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 17777700.0 4790900.0 5240800.0 7746000.0 True False 4638815.501906073 7333478.770410946 5717090.224981064 1.0 1.5808946847309717 1.2324461325594718 22.145325036814288 -10.361963624158852 5.239251963104292 0.9998153245195904 1.4066704086452417 0.6449025557487547 0.1422535257386931 0.0003069998990115979 3.7386289544783384e-05 0.13779823902551633 0.04591212801042708 4.345466196071535e-11 10.361963624158852 0.4068550841256513 GGSDDSSK(ub)DPIDVNYEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGSDDSSKDPIDVNYEK 17 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 18814300.0 8237200.0 5166200.0 5410900.0 True False 11282715.441959985 4937940.201661176 4132956.860983528 1.0 0.43765529912215695 0.36630870309936386 23.42761099109606 -13.999999999999998 0.2911030503938506 5.875955377466976 0.3470816897438505 0.9996299312252174 0.0054519868280361 16.03169046126332 0.17112321458918436 46.84271053717291 0.026812344360473764 1.0000000000000041e-14 13.999999999999998 -5.5288736877231255 GGSDDSSK(ub)DPIDVNYEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGSDDSSKDPIDVNYEK 17 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 16189000.0 4790900.0 8218600.0 3179500.0 True False 3983845.6228564037 8174324.770535629 3844318.7496530013 1.0 2.051867854426213 0.9649768373546156 21.925730312248565 -6.653575596915214 1.995320527632031 1.6805880497178896 0.9694929921316754 0.2089188287227126 0.448549847103061 0.4997820902769414 3.8177956091177174 0.18204164684324495 0.4970778275424562 2.2203651545559592e-07 6.653575596915214 -0.7110950575862142 GGSDDSSK(ub)DPIDVNYEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGSDDSSKDPIDVNYEK 17 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 41699000.0 12795000.0 10436000.0 18468000.0 True False 16563379.72715639 9855227.426018715 15107013.497682165 1.0 0.5950009954707877 0.9120731243584033 23.98149374635514 -9.835369373208803 6.2085047209928685 1.0000000144922856 0.753537059914482 0.4461711152092801 0.129444154572512 2.5824770330053446e-08 5.113875344304548e-09 0.12533376933348134 0.041777921243543584 1.4609341021039546e-10 9.835369373208803 -0.24646295457780354 GGSDDSSKDPIDVNYEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGSDDSSKDPIDVNYEK 17 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 18774600.0 4177000.0 2207600.0 12390000.0 False True 4044403.4213741994 3089106.192481917 9144687.307967376 1.0 0.7637977398981396 2.261071993866579 21.947495479766783 -6.86655912601159 1.1522200272684253 0.8688385571484121 2.3431830225697308 0.9611225239288492 0.12959453117800568 0.1401925360483951 0.3500316938805089 0.08746254426948931 0.20591001197532044 1.359693038438539e-07 6.86655912601159 1.4743444654213187 up GGSDDSSKDPIDVNYEK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGSDDSSKDPIDVNYEKLK 19 2 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 42450900.0 12870000.0 14053200.0 15527700.0 True False 12461448.894681817 19664716.04646984 11460529.548985077 1.0 1.5780441112960923 0.9196787344588876 23.570968484712054 -6.674746742625869 1.920075784512683 1.3674273702322253 0.9222459888449467 0.30051463230959996 0.2452716605251834 0.4502672430169262 3.2045339463589633 0.10266387722128864 0.27265252316118843 2.1147218733256898e-07 6.674746742625869 -0.4451813813872786 GGSDDSSKDPIDVNYEK(ub)LK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGSDDSSKDPIDVNYEKLK 19 2 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 28743400.0 10841000.0 5742000.0 12160400.0 True False 14849210.667009223 5488299.453745212 9288363.971299415 1.0 0.3696021005304122 0.6255123036226803 23.82388290856705 -10.331829899100327 5.79256966050052 1.000067711864227 0.4975572020765834 0.8371252825120804 0.1044749029246848 9.137080366809654e-05 1.0539799851585986e-05 0.10117093675102261 0.03371912992699413 4.657684861810492e-11 10.331829899100327 -0.5025105097876436 GGSDDSSKDPIDVNYEK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGSDDSSKDPIDVNYEKLK 19 2 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 44618900.0 12870000.0 21308000.0 10440900.0 True False 10701975.237671811 21193209.574693173 12624043.916732827 1.0 1.9803082238586551 1.179599432476276 23.35137376014633 -10.15246499890222 4.409769716015627 0.9999131343012106 1.5799538276896083 0.41158532151029026 0.32688799550726694 304965699.3638724 212413755.779854 370211.1132562942 0.11962875877201443 7.039389582070681e-11 10.15246499890222 0.5800406933883977 GGSFENNWNIYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGSFENNWNIYK 12 0 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 0 17353400.0 4579400.0 5850200.0 6923800.0 False True 6003637.746972676 4977372.963900994 6207391.593779373 1.0 0.829059509196874 1.0339383979170693 22.517405498245978 -6.685339885468237 1.883231420228944 0.8923629067302862 1.0331875736976908 0.34853782410823975 0.07236625332406983 0.4267945063047639 2.9309750654822766 0.030785075125141916 0.080632963314901 2.063764390224853e-07 6.685339885468237 0.1408246669674046 GGSFENNWNIYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGSFENNWNIYK 12 0 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 0 9307700.0 4579400.0 4728300.0 0.0 False True 6272527.933631757 4519388.071602836 0.0 1.0 0.7205050530538071 0.0 22.58061555976887 -7.388622945525666 0.7670397591735575 0.9901403359830473 4.7726530422426655e-18 0.9875352365149329 0.04703341639317338 0.11224098693911948 0.13870275616619718 0.04064730163319387 0.07271711409395876 4.0867404316299904e-08 7.388622945525666 -0.9901403359830473 down GGSGATLEDLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGSGATLEDLDR 12 0 P56945-4;P56945-5;P56945-8;P56945;P56945-7;P56945-3;P56945-2;P56945-6 P56945-4 BCAR1 Breast cancer anti-estrogen resistance protein 1 0 2984200.0 2984200.0 0.0 0.0 False True 3912315.0990339043 0.0 0.0 1.0 0.0 0.0 21.899591139385954 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 GGSGATLEDLDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGSGATLEDLDR 12 0 P56945-4;P56945-5;P56945-8;P56945;P56945-7;P56945-3;P56945-2;P56945-6 P56945-4 BCAR1 Breast cancer anti-estrogen resistance protein 1 0 17584600.0 2984200.0 7539700.0 7060700.0 False True 4087539.38497268 7206571.1235462865 5393108.079681088 1.0 1.763058516338786 1.3194021076611924 21.962801200908846 -10.212290463173755 4.351477012557471 0.9998106547634983 1.5412303120167623 0.6649141257780963 0.1811219705990273 127478245.44828008 94.56250777539277 258202.46592060375 0.062002868066223765 6.133516484506833e-11 10.212290463173755 0.541419657253264 GGSGSHNWGTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGSGSHNWGTVK 12 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 601457000.0 50799000.0 357120000.0 193538000.0 False True 66597980.938215815 303839088.0428569 173512544.30758703 1.0 4.562286780506665 2.6053724431759853 25.988975103751645 -9.431016996158428 8.534348337486065 0.9999890802635407 3.583829611841502 0.6991996420632005 0.7989069328249953 0.0 4.736750680814004e-17 0.7735383114886835 0.2578461038295611 3.7066621543893276e-10 9.431016996158428 2.5838405315779616 GGSGSHNWGTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGSGSHNWGTVK 12 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 264203000.0 94641000.0 101811000.0 67751000.0 False True 91636673.2588642 142464663.23735103 50004980.613567226 1.0 1.5546686514350316 0.545687428790745 26.449421748781045 -6.7574548736738915 1.6220790176109305 1.3231978718443604 0.5424604595541345 0.6804956196178842 0.2332172967046047 0.28720671807554937 1.4887776501221475 0.11347447450135847 0.27338368630676757 1.748014884324468e-07 6.7574548736738915 -0.780737412290226 GGSGSHNWGTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGSGSHNWGTVK 12 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 569493000.0 285140000.0 179852000.0 104501000.0 False True 432578226.52628154 147756005.40991014 83846331.54558466 1.0 0.34157060237735554 0.19382929237768867 28.68838580934307 -13.999999999999917 0.20998377293544757 4.807677235644378 0.10679605527979831 0.9994900025792798 0.007914006691376907 12.74630166609847 0.1452428577236046 20.023481264229567 0.08752456198467969 1.0000000000001922e-14 13.999999999999917 -4.700881180364579 GGSGSHNWGTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGSGSHNWGTVK 12 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 579007000.0 50799000.0 262649000.0 265559000.0 False True 69580763.09135698 251044298.71590498 202839433.5592827 1.0 3.607955526246429 2.915165407038753 26.052185165274537 -10.119016515838872 5.555980837585738 0.9999711808990025 3.261560466643033 0.9342477969857408 0.28283038181834613 0.00010096548515206691 1.6011741942431876e-05 0.2738527945878842 0.0912831132151024 7.602973629474128e-11 10.119016515838872 2.2615892857440305 GGSGSHNWGTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGSGSHNWGTVK 12 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 299811600.0 94641000.0 189400000.0 15770600.0 False True 78698184.80718711 188379664.6070433 19068159.54498431 1.0 2.393697708131122 0.2422947821693965 26.22982702421532 -6.731805086484567 1.7165738128899253 1.836990042468994 0.24309952726414438 0.5677589098030307 0.5857931054134303 0.33280465457721276 1.9219786434474972 0.2703412471098939 0.6694860135091659 1.8543636842943165e-07 6.731805086484567 -1.5938905152048497 GGSGSHNWGTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGSGSHNWGTVK 12 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 484258000.0 285140000.0 122785000.0 76333000.0 False True 369119350.94969743 115951906.81331043 62441177.242721036 1.0 0.31413120584163584 0.16916256783088662 28.45951213143552 -13.999999999999998 0.21843867856901786 5.110724223618645 0.0904488339769568 0.999496377356204 0.00813184436152811 12.957623159743868 0.14807362595162524 22.957606120814898 0.08106350461421108 1.0000000000000041e-14 13.999999999999998 -5.020275389641688 GGSGSHNWGTVKDELTDLDQSNVTEETPEGEEHHPVADTENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGSGSHNWGTVKDELTDLDQSNVTEETPEGEEHHPVADTENK 42 1 Q8NC51-3;Q8NC51-4 Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 21450600.0 8401200.0 4839200.0 8210200.0 False True 8134508.504584385 6771517.796094627 6059702.319279567 1.0 0.8324433851508528 0.7449377323613942 22.955623748729057 -13.999999999999202 0.08204635569706678 1.8927236376254124 0.4932387055952396 0.9998780888917771 0.001168428450724995 12.238400762980612 0.08118261320714115 1.9649026990608263 0.2280201779974946 1.0000000000018365e-14 13.999999999999202 -1.3994849320301728 GGSGSHNWGTVKDELTDLDQSNVTEETPEGEEHHPVADTENK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGSGSHNWGTVKDELTDLDQSNVTEETPEGEEHHPVADTENK 42 1 Q8NC51-3;Q8NC51-4 Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 188566000.0 73229000.0 66194000.0 49143000.0 False True 111093746.75700709 54381163.52391741 39429864.50985793 1.0 0.4895069714667571 0.3549242478616011 26.727202371716523 -13.999999999999998 0.18714860351951457 3.7101371867960635 0.2555535223006125 0.9994912320443088 0.006267297805172069 12.305661149640088 0.13718230360637093 12.150440913817306 0.0946969223762062 1.0000000000000041e-14 13.999999999999998 -3.454583664495451 GGSGSHNWGTVKDELTDLDQSNVTEETPEGEEHHPVADTENK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGSGSHNWGTVKDELTDLDQSNVTEETPEGEEHHPVADTENK 42 1 Q8NC51-3;Q8NC51-4 Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 254751000.0 73229000.0 108150000.0 73372000.0 False True 94796384.05939305 102131357.42850931 60019048.860295415 1.0 1.0773760881482637 0.6331364793692079 26.498328693808972 -6.861959690871419 1.175687835840808 1.042224437181935 0.6107940371292514 0.9559846449002596 0.040652834779033246 0.14480267418688214 0.3792039541923749 0.026945371758689725 0.06304837829717101 1.3741695129099213e-07 6.861959690871419 -0.4314304000526835 GGSGSHNWGTVKDELTDLDQSNVTEETPEGEEHHPVADTENKENEVEEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGSGSHNWGTVKDELTDLDQSNVTEETPEGEEHHPVADTENKENEVEEVK 50 2 Q8NC51-3;Q8NC51-4 Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 87689000.0 33049000.0 23620000.0 31020000.0 False True 42782581.993184134 22305526.23635131 25374678.292078253 1.0 0.5213693329660396 0.5931076879866857 25.35052021815803 -10.64543449946549 6.609952370166255 1.0020068216106537 0.5572385104764096 0.9806911379681073 0.029287060797868445 0.0008692467641856129 4.662732371157207e-05 0.02845900919219568 0.00945235822745905 2.2623797274045515e-11 10.64543449946549 -0.4447683111342441 GGSGSHNWGTVKDELTESPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGSGSHNWGTVKDELTESPK 20 1 Q8NC51;Q8NC51-2 Q8NC51 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 124517000.0 32083000.0 57512000.0 34922000.0 False True 42061123.69221394 48931433.78002013 31308606.43547809 1.0 1.1633410970681695 0.7443597243046011 25.3259840573989 -6.800977649780397 1.4518186044178407 1.0900150444807206 0.7384304054769937 0.8349993309355777 0.07004006146965112 0.21938665903378934 0.9128082651660986 0.037949510416421854 0.08820844647088164 1.581329417578883e-07 6.800977649780397 -0.35158463900372694 GGSGSHNWGTVKDELTESPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGSGSHNWGTVKDELTESPK 20 1 Q8NC51;Q8NC51-2 Q8NC51 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 28126800.0 11973000.0 6672300.0 9481500.0 False True 11592923.668688862 9336584.185584836 6998010.711097072 1.0 0.80536924527519 0.6036450261462417 23.46674111583642 -6.970675622011387 0.24150343377224967 1.071096331288367 0.3320724762789286 0.9999871822480242 0.0005793169497871021 0.0760840776323639 0.008241729947592634 0.004771088472457922 0.019613808744040732 1.0698536630518631e-07 6.970675622011387 -0.7390238550094383 GGSGSHNWGTVKDELTESPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGSGSHNWGTVKDELTESPK 20 1 Q8NC51;Q8NC51-2 Q8NC51 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 803772200.0 358170000.0 309564200.0 136038000.0 False True 543370075.7344389 254320049.87386617 109150029.6724265 1.0 0.46804206052406894 0.2008760411123033 29.017359875306063 -9.197587880244182 0.23143604569993248 1.3819406060231243 4.131042970597651e-16 0.999293460615282 0.00882900676933918 0.6265217151660534 0.08329212416211595 0.30511681808516106 0.12251275582434204 6.34471501578338e-10 9.197587880244182 -1.3819406060231239 GGSGSHNWGTVKDELTESPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGSGSHNWGTVKDELTESPK 20 1 Q8NC51;Q8NC51-2 Q8NC51 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 161967000.0 32083000.0 91347000.0 38537000.0 False True 43944952.11047469 87310987.4958661 29435354.294428263 1.0 1.9868263202647731 0.6698233330742912 25.389194118921793 -6.706143294084702 1.8087069849767252 1.6090419318499731 0.6732218191698669 0.44690176171955853 0.41610169921949136 0.38286924199054684 2.4390454409464466 0.18323520771118504 0.4677364622725139 1.9672370989819407e-07 6.706143294084702 -0.9358201126801062 GGSGSHNWGTVKDELTESPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGSGSHNWGTVKDELTESPK 20 1 Q8NC51;Q8NC51-2 Q8NC51 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 35393200.0 11973000.0 21399000.0 2021200.0 False True 9956079.993834097 21283719.339631084 2443823.5750270956 1.0 2.137760981512032 0.2454604198178983 23.247146391270697 -6.743895913061947 1.6724309662298824 1.6738967040851307 0.24338296996763858 0.6222834337387163 0.47801993144630356 0.31082220251103704 1.708440978791935 0.22598238690073505 0.5521871530690791 1.803449920164013e-07 6.743895913061947 -1.430513734117492 GGSGSHNWGTVKDELTESPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGSGSHNWGTVKDELTESPK 20 1 Q8NC51;Q8NC51-2 Q8NC51 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 928264000.0 358170000.0 318070000.0 252024000.0 False True 463658125.5862132 300369124.8939988 206158217.98461413 1.0 0.6478245679707123 0.44463410993598734 28.788486197398512 -9.840149882246854 0.11882700123799107 1.7276728824743706 1.0428001384842752e-10 0.9998849474640835 0.0024609231128682085 1.3703583811604718 0.0525927157588469 0.5434907831934332 0.23367671365632298 1.4449410115172704e-10 9.840149882246854 -1.7276728823700906 GGSGSVLQDEEVLASLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGSGSVLQDEEVLASLER 18 0 A0A0D9SG79;Q9NZ09-2;Q9NZ09;Q9NZ09-3;Q9NZ09-4 A0A0D9SG79 UBAP1 Ubiquitin-associated protein 1 0 23446600.0 3982700.0 10976000.0 8487900.0 False True 5221358.268521667 9338423.584112894 7609653.529686007 1.0 1.7885046579569224 1.457408807888707 22.315993723314797 -10.170315750153673 4.753448311994855 0.9999291080982656 1.6229567329263865 0.8251764961520296 0.13516931478230132 0.00010156275314376761 1.772708376878124e-05 0.1308919387336256 0.04362570875410214 6.755916135877562e-11 10.170315750153673 0.6230276248281209 GGSGSVLQDEEVLASLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGSGSVLQDEEVLASLER 18 0 A0A0D9SG79;Q9NZ09-2;Q9NZ09;Q9NZ09-3;Q9NZ09-4 A0A0D9SG79 UBAP1 Ubiquitin-associated protein 1 0 23295900.0 5359600.0 10600000.0 7336300.0 False True 5189462.431696717 14832635.278269734 5414702.945717606 1.0 2.8582219205737927 1.0434034385999487 22.3071536691226 -6.640594331687233 2.0415256147444243 2.21454787784457 1.0508334722515733 0.15722570437649674 0.7949430909770622 0.531836569252609 4.236850347707352 0.3169554214371469 0.8806868172076756 2.2877347462059172e-07 6.640594331687233 -1.1637144055929967 GGSGSVLQDEEVLASLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGSGSVLQDEEVLASLER 18 0 A0A0D9SG79;Q9NZ09-2;Q9NZ09;Q9NZ09-3;Q9NZ09-4 A0A0D9SG79 UBAP1 Ubiquitin-associated protein 1 0 59567000.0 23652000.0 24844000.0 11071000.0 False True 35881813.19281615 20410394.09294204 8882811.997408329 1.0 0.5688228179346404 0.2475575007783259 25.096749459100526 -8.007765376749576 0.26994418271399934 1.1548094045386184 1.9355625302494613e-21 0.9994641557356696 0.0071360162901770805 0.09944539146717585 0.050689260270638574 0.06459119447741396 0.09368846901312036 9.82278465819552e-09 8.007765376749576 -1.1548094045386184 down GGSGSVLQDEEVLASLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGSGSVLQDEEVLASLER 18 0 A0A0D9SG79;Q9NZ09-2;Q9NZ09;Q9NZ09-3;Q9NZ09-4 A0A0D9SG79 UBAP1 Ubiquitin-associated protein 1 0 28698700.0 3982700.0 12685000.0 12031000.0 False True 5455211.818420589 12124534.756314522 9189525.586222759 1.0 2.222559849165464 1.684540562695023 22.37920378483769 -10.040590347679926 5.378977435063822 0.9999934128426862 1.9535502059314156 0.8072559149035864 0.21964545394225632 1.73506703841728e-05 3.095453753141355e-06 0.21267226528088828 0.07089026543178274 9.107719617316536e-11 10.040590347679926 0.9535567930887294 GGSGSVLQDEEVLASLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGSGSVLQDEEVLASLER 18 0 A0A0D9SG79;Q9NZ09-2;Q9NZ09;Q9NZ09-3;Q9NZ09-4 A0A0D9SG79 UBAP1 Ubiquitin-associated protein 1 0 62266000.0 23652000.0 24434000.0 14180000.0 False True 30617980.250621565 23074226.42078778 11599385.499086713 1.0 0.7536168693008207 0.37884228169659356 24.867875781192975 -6.9650243504273694 0.357640647362447 1.033177351602775 0.08648578185314675 0.9999136384109208 0.0023733179118459197 0.07795277468129809 0.014831257040324322 0.005052988520661863 0.03205623217753268 1.0838661411015297e-07 6.9650243504273694 -0.9466915697496282 down GGSGYVNQLSAGYESVDSPTGSENSLTHQSNDTDSSHDPQEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGSGYVNQLSAGYESVDSPTGSENSLTHQSNDTDSSHDPQEEK 43 0 Q15007 Q15007 WTAP Pre-mRNA-splicing regulator WTAP 0 13965900.0 1766200.0 5864300.0 6335400.0 False True 2419211.8697603215 5605195.835353195 4839109.001658695 1.0 2.3169511961383185 2.000283258422554 21.206105692535125 -10.106010946489537 4.704714048301368 0.9999299483000977 2.1586172272946533 0.9469463968134351 0.12927914428106302 45021506.44210366 4.740075081207373 35167.80298384653 0.04425568970141607 7.834098964957244e-11 10.106010946489537 1.1586872789945555 GGSGYVNQLSAGYESVDSPTGSENSLTHQSNDTDSSHDPQEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGSGYVNQLSAGYESVDSPTGSENSLTHQSNDTDSSHDPQEEK 43 0 Q15007 Q15007 WTAP Pre-mRNA-splicing regulator WTAP 0 29456200.0 13977000.0 10784000.0 4695200.0 False True 18093502.02785968 10183860.920102134 3840721.776820305 1.0 0.5628463137993638 0.21227077936081742 24.108968335257945 -7.914379485415857 0.30981824013128967 1.1095150822200917 1.1842124444462282e-21 0.9991762163181491 0.009248694919307136 0.10756427183424269 0.055729581941957415 0.049732326459786196 0.08657540726779706 1.2179249141348323e-08 7.914379485415857 -1.1095150822200917 down GGSISVQVNSIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGSISVQVNSIK 12 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 43195000.0 11197000.0 17458000.0 14540000.0 False True 14679375.431902247 14853334.45075099 13035540.277528524 1.0 1.0118505735925716 0.888017364090217 23.807287250889534 -6.883426570766891 1.0604610210481695 1.007739410047 0.8786421142838009 0.9763476631257277 0.008580500543386738 0.12463998893906851 0.25428872992951485 0.006212230733455518 0.015163049711209959 1.3078966555449148e-07 6.883426570766891 -0.12909729576319917 GGSISVQVNSIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGSISVQVNSIK 12 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 38015200.0 12254000.0 7792200.0 17969000.0 False True 11865003.477500467 10903666.095786186 13262379.84155497 1.0 0.9189770670074173 1.1177729418035434 23.50020918758132 -6.796039625975137 1.4719189827816719 0.9550691558089301 1.1202595337345682 0.8203609002041634 0.03459328552043147 0.2264603228536604 0.9689788594974807 0.018492377572332675 0.043116406660063354 1.599412088111734e-07 6.796039625975137 0.16519037792563807 GGSISVQVNSIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGSISVQVNSIK 12 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 53609000.0 16093000.0 20990000.0 16526000.0 False True 24414257.55589341 17244170.50438148 13259628.856396884 1.0 0.7063155807586241 0.5431100587859619 24.54122057011167 -13.072557542233652 0.07652638751134336 2.4403964736442165 1.1449606564290557e-19 0.9999197116790345 0.001693885541479861 8.888552510691715 0.06792443434608265 2.4407346486259853 0.45305076452188997 8.461404512482101e-14 13.072557542233652 -2.4403964736442165 GGSISVQVNSIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGSISVQVNSIK 12 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 31232500.0 11197000.0 8472500.0 11563000.0 False True 15336833.48754747 8098156.935189186 8832057.54746021 1.0 0.5280201380398615 0.575872298191884 23.870497312412425 -10.421506817988451 9.231909676439189 1.0000020451885432 0.5519462185899184 0.991517875361439 0.019535562577066193 8.223375583748668e-07 5.15366910131178e-08 0.018915313343098105 0.006305075709980855 3.788725857815656e-11 10.421506817988451 -0.44805582659862475 GGSISVQVNSIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGSISVQVNSIK 12 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 28783100.0 12254000.0 9137600.0 7391500.0 False True 10189743.944244787 9088373.935128411 8937028.475565383 1.0 0.8919138679889562 0.8770611434856571 23.280614463015596 -13.99999999999996 0.2796519791429062 1.8792044171551956 0.8725744709267971 0.9996043969547319 0.001089738905051605 15.379591322248535 0.1675160689877429 7.731865870263277 0.005885123365310291 1.000000000000094e-14 13.99999999999996 -1.0066299462283985 GGSISVQVNSIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGSISVQVNSIK 12 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 51235000.0 16093000.0 24061000.0 11081000.0 False True 20832705.740455493 22721984.198681153 9064371.700661482 1.0 1.0906880979246412 0.43510294887231943 24.31234689220412 -6.8719290179260915 1.123896915304641 1.0519351867469313 0.3952838434364747 0.9665680221980695 0.053032675948540026 0.1350158138466347 0.3175791269193467 0.036577083809350756 0.08689610610564197 1.3429844436206812e-07 6.8719290179260915 -0.6566513433104566 down GGSK(ub)GIPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGSKGIPLK 9 1 Q8NFW8;F5H296;Q8NFW8-2 Q8NFW8 CMAS N-acylneuraminate cytidylyltransferase 1 7324400.0 2121000.0 3231600.0 1971800.0 True False 2780651.5397932148 2749457.8766781413 1767777.0508411785 1.0 0.9887818870258755 0.6357420286371591 21.406991532523513 -6.913668293483365 0.8703718935894733 1.0097039107017285 0.586346402105949 0.9922340091929768 0.014904621319024003 0.10204222418174692 0.1259756955789922 0.012428397113239183 0.035246403290973 1.2199209974720467e-07 6.913668293483365 -0.4233575085957795 GGSK(ub)GIPLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGSKGIPLK 9 1 Q8NFW8;F5H296;Q8NFW8-2 Q8NFW8 CMAS N-acylneuraminate cytidylyltransferase 1 5896800.0 1984000.0 2286400.0 1626400.0 True False 1921019.005986693 3199371.4434184874 1200397.0490458575 1.0 1.6654553825068452 0.6248751549593844 20.873440361990866 -6.73399705488077 1.7089642556428402 1.3986797650961678 0.6250626899663737 0.5775779063310165 0.2796636663695106 0.32878608572213047 1.8829917113869943 0.1295974703598977 0.32010457022193506 1.8450279309866506e-07 6.73399705488077 -0.773617075129794 GGSK(ub)GIPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGSKGIPLK 9 1 Q8NFW8;F5H296;Q8NFW8-2 Q8NFW8 CMAS N-acylneuraminate cytidylyltransferase 1 5391000.0 2121000.0 1560100.0 1709900.0 True False 2905191.0178697994 1491169.623439201 1306056.8364959129 1.0 0.5132776517161978 0.44955971172372866 21.470201594046404 -13.999999999999998 0.28660277066021106 5.1148410009129215 0.4315942771204382 0.9996198658497814 0.004793178718441901 15.766874546732328 0.1697011870399572 38.17622850883013 0.024439807908450312 1.0000000000000041e-14 13.999999999999998 -4.683246723792483 GGSMHMYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGSMHMYAK 9 0 P08559;P08559-4;P08559-3;P08559-2;Q5JPU0;Q5JPT9;Q5JPU1 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 0 5586800.0 2048100.0 1134100.0 2404600.0 False True 2805337.9178213775 1083991.7120328182 1836683.0042915174 1.0 0.3864032582836385 0.6547100770369523 21.419743130889874 -10.399014721041755 5.99532254267201 1.0001195739820865 0.520556667660324 0.8097938367884336 0.10953580007583871 0.00017511132598281237 1.755354980558453e-05 0.1060837418958962 0.035352527458935606 3.9901137706320306e-11 10.399014721041755 -0.47956290632176246 GGSMHMYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGSMHMYAK 9 0 P08559;P08559-4;P08559-3;P08559-2;Q5JPU0;Q5JPT9;Q5JPU1 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 0 2326910.0 1102300.0 812440.0 412170.0 False True 916611.2901698243 808063.2244632873 498352.84134124074 1.0 0.8815767742873581 0.5436904898355648 19.805950530356 -6.95257287169685 0.5298467257042123 1.0053348473645929 0.40459776418308024 0.9993880247668918 0.004782770299237979 0.08246878939070625 0.031811921940228576 0.005337099292301867 0.027940833405620775 1.1153909805339839e-07 6.95257287169685 -0.6007370831815126 GGSVLVTCSTSCDQPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGSVLVTCSTSCDQPK 16 0 P05362;K7EKL8 P05362 ICAM1 Intercellular adhesion molecule 1 0 8626500.0 2600100.0 2053100.0 3973300.0 False True 3408756.2794042164 1746785.4829211186 3562181.0305848727 1.0 0.5124407084998234 1.045009011676092 21.700814022112525 -6.665892842676945 1.9518347572318682 0.68770095657783 1.04282611973201 0.26100038569888295 0.20730262206349895 0.47063311810371805 3.452531773318291 0.08562375285848858 0.2300056317763541 2.1582768742240664e-07 6.665892842676945 0.35512516315417986 GGSVLVTCSTSCDQPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGSVLVTCSTSCDQPK 16 0 P05362;K7EKL8 P05362 ICAM1 Intercellular adhesion molecule 1 0 9030500.0 2600100.0 3412000.0 3018400.0 False True 3561427.2350604767 3261246.55802484 2305516.0858993246 1.0 0.9157133763451608 0.6473573468531569 21.764024083635416 -6.950106159760726 0.557675083197429 1.0035533778654324 0.5467432162385261 0.9992095995786963 0.004227256050930963 0.08344310401410876 0.03578589290239817 0.004544207808775968 0.022296568048271067 1.121744219517366e-07 6.950106159760726 -0.45681016162690635 GGSYSK(ub)AEWSDSAQGSESHSL ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGSYSKAEWSDSAQGSESHSL 21 1 P13747 P13747 HLA-E HLA class I histocompatibility antigen, alpha chain E 1 17035200.0 2881400.0 2330800.0 11823000.0 True False 2789931.5341986166 3261500.59496143 8726201.617602775 1.0 1.1690253165650775 3.1277475847124325 21.411798287620893 -6.923903834651082 0.7952401810516815 0.9625552948758965 3.4738234773936405 0.9951983955256806 0.06691398465581753 0.09592875216189237 0.09410888921338689 0.05887921322180654 0.18352772908811738 1.1915058126394185e-07 6.923903834651082 2.511268182517744 up GGSYSK(ub)AEWSDSAQGSESHSL ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGSYSKAEWSDSAQGSESHSL 21 1 P13747 P13747 HLA-E HLA class I histocompatibility antigen, alpha chain E 1 17937600.0 2881400.0 2422200.0 12634000.0 True False 2396011.7676633694 2409151.127830944 15275710.9869841 1.0 1.0054838462585634 6.375474107909423 21.19220356305517 -6.907117644110135 0.9151211896235576 0.8182008324224521 7.028354754090398 0.9897880854176643 0.2559426676342528 0.1063555692917662 0.14932745035873857 0.20660209105108235 0.5595565526379801 1.2384610598523354e-07 6.907117644110135 6.210153921667946 up GGTLKDDDWGNIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGTLKDDDWGNIK 13 1 P54578-2;P54578 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14 0 8614100.0 1668500.0 3018900.0 3926700.0 False True 2187419.6577769835 2568491.887580031 3520402.751566116 1.0 1.174210846303869 1.6093860814727285 21.06079859817528 -6.955478928569656 0.49505548919057607 0.9908985932342735 1.8113107459792896 0.9995640486780093 0.005350815790999625 0.08135744503821407 0.02741334179928313 0.006335056002303421 0.035893502663559104 1.1079523205444919e-07 6.955478928569656 0.8204121527450161 GGTLKDDDWGNIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGTLKDDDWGNIK 13 1 P54578-2;P54578 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14 0 30724400.0 5831400.0 10227000.0 14666000.0 False True 5646285.398946973 14310694.433100455 10824534.629430968 1.0 2.534532603642279 1.9171072421259001 22.42887062287962 -10.091981436546662 6.604830427218178 0.999998766590433 2.225819922884092 0.84014349578283 0.25206284832810183 4.578399494624808e-06 6.288106495457338e-07 0.2440590470187228 0.08135293448102755 8.091304838567493e-11 10.091981436546662 1.2258211562936587 GGTLKDDDWGNIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGTLKDDDWGNIK 13 1 P54578-2;P54578 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14 0 7934900.0 1668500.0 1973800.0 4292600.0 False True 2285389.539517097 1886590.989516246 3278776.2888720706 1.0 0.8255008421517859 1.434668458999281 21.12400865969817 -6.830137136714434 1.3274088848411116 0.906770345780307 1.4510937658333116 0.9061285573225927 0.0784774847144775 0.18064211554906964 0.6224701940855671 0.04642009649134809 0.10681911337711275 1.4786414053923048e-07 6.830137136714434 0.5443234200530046 GGTLKDDDWGNIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGTLKDDDWGNIK 13 1 P54578-2;P54578 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14 0 29133700.0 5831400.0 18767000.0 4535300.0 False True 4849067.474822019 18665898.446042173 5483610.261142083 1.0 3.8493789873953626 1.1308587248197355 22.209275898313898 -6.635103970341165 2.061658411777662 2.8701191618384247 1.1419126034721205 0.1363258865862289 1.2206456280261644 0.5457852221855048 4.427226106954563 0.4831146307910671 1.3521495438606521 2.3168399307996015e-07 6.635103970341165 -1.7282065583663042 GGTMTDLDEQEDESMETTGK(ub)DEDENSTGNKGEQTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGTMTDLDEQEDESMETTGKDEDENSTGNKGEQTK 35 2 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 7966200.0 2478000.0 3658700.0 1829500.0 True False 2060566.7940132674 3638989.856904909 2212039.991347745 1.0 1.7660140246254394 1.0735104524515124 20.974609799178868 -10.479474119635743 6.49893389847022 0.9998261638566937 1.419762238538476 0.32881096304946733 0.2827133994801241 0.0007123727510551605 5.7057188929216746e-05 0.27384757479503646 0.09124535732801708 3.3153232581166295e-11 10.479474119635743 0.4199360746817824 GGTVADLDEQDEETVTAGGKEDEDPAK(ub)GDQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGTVADLDEQDEETVTAGGKEDEDPAKGDQSR 32 2 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 15114800.0 4021200.0 5807900.0 5285700.0 True False 5507946.308843965 5551287.7738430565 4037326.5224085865 1.0 1.0078688975107655 0.7330003409666426 22.393083065554116 -6.9003110505921965 0.9593157727650615 1.011330690893778 0.7039669856212393 0.986719961220373 0.014722935097304692 0.11117613107071515 0.17613845874621348 0.011504012756957319 0.029977913444881946 1.2580240664802136e-07 6.9003110505921965 -0.30736370527253876 GGTVADLDEQDEETVTAGGKEDEDPAK(ub)GDQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGTVADLDEQDEETVTAGGKEDEDPAKGDQSR 32 2 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 16044800.0 6443900.0 6751300.0 2849600.0 True False 5358388.36317276 6714929.406871874 3445438.184938256 1.0 1.2531621360300005 0.6429989674914445 22.35336771737992 -6.7940252609135205 1.4802625425520282 1.1407543052978493 0.6357747551300352 0.8140956667001801 0.1079198672966369 0.2293980928721716 0.9928694966732854 0.057373730195167984 0.13394000061019334 1.6068477873457072e-07 6.7940252609135205 -0.504979550167814 GGTWFAGFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGTWFAGFGR 10 0 G3V0I5;P49821-2;P49821;B4DE93;H0YD04;H0YE81 G3V0I5 NDUFV1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0 19522800.0 5728600.0 6242000.0 7552200.0 False True 7510250.075841316 5310717.931125428 6770770.789817818 1.0 0.7071293069466144 0.9015373285102415 22.840429516633545 -10.21205447788302 4.8629071714686685 1.000028827700684 0.8043333184348233 0.5745864915999204 0.07936674245721054 2.480914683416032e-05 4.0198327946422934e-06 0.07685783221442019 0.025615505981426683 6.13685019711221e-11 10.21205447788302 -0.19569550926586066 GGTWFAGFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGTWFAGFGR 10 0 G3V0I5;P49821-2;P49821;B4DE93;H0YD04;H0YE81 G3V0I5 NDUFV1 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial 0 16021700.0 5728600.0 4656600.0 5636500.0 False True 7846618.229594038 4450856.014683031 4305274.787361373 1.0 0.5672323903686729 0.5486790183220264 22.903639578156437 GGVAGGSILK(ub)GVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGVAGGSILKGVLK 14 1 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 22163100.0 5490000.0 9380300.0 7292800.0 True False 7197443.165235625 7980795.80412301 6538211.013477301 1.0 1.1088376275996255 0.9084074529490582 22.77905306088552 -6.759210018268184 1.6152262919471934 1.0632792275360128 0.9076976933216054 0.6878488077591667 0.04577255540001693 0.2842310156049637 1.4613003848151165 0.022360049359927883 0.05378138956481166 1.7409647654622066e-07 6.759210018268184 -0.15558153421440735 GGVAGGSILK(ub)GVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGVAGGSILKGVLK 14 1 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 39300300.0 7477700.0 14667200.0 17155400.0 True False 7240324.50658603 20523889.448437553 12661886.089031767 1.0 2.8346643067956925 1.748800910444568 22.787622928725312 -10.655999596245419 6.2278790987319566 0.9906936639898485 2.291732608619622 0.653599705593827 0.4433018752376308 0.0566826463154727 0.003130894693385649 0.42473111727671004 0.14307506501148842 2.2080067857561043e-11 10.655999596245419 1.3010389446297734 GGVAGGSILK(ub)GVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGVAGGSILKGVLK 14 1 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 47897500.0 9717700.0 7165800.0 31014000.0 True False 14742461.35903221 5887007.003349056 24884069.306080926 1.0 0.39932321068912174 1.6879182315668946 23.81347407697705 -6.779946547251682 1.5360589001380511 0.6598588402363603 1.6981124628004198 0.7672079417937219 0.25401328274450186 0.25065725606797074 1.1681634227096875 0.13024656774384297 0.30734350721891635 1.6597911811374465e-07 6.779946547251682 1.0382536225640595 GGVAGGSILK(ub)GVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGVAGGSILKGVLK 14 1 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 24828200.0 5490000.0 8510400.0 10827800.0 True False 7519801.36167148 8134382.387870647 8270496.645540923 1.0 1.081728359120188 1.0998291374684104 22.84226312240841 -13.999999997518742 0.2118298847927557 0.5237445634600166 1.110303267482666 0.9994911005175949 0.0009796405812561337 12.790358987201571 0.145869207164855 2.537517658746679 0.010586366014171771 1.0000000057133074e-14 13.999999997518742 0.5865587040226494 GGVAGGSILK(ub)GVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGVAGGSILKGVLK 14 1 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 23718500.0 7477700.0 9240000.0 7000800.0 True False 6218038.868278049 9190222.286003599 8464634.911958091 1.0 1.4779937019835052 1.3613029913886963 22.56802820415959 -10.081681281062192 4.96726948304263 0.999988482811182 1.4196483466883603 0.9451873610402768 0.047638783121170356 6.0762737608541856e-06 1.1233667601714442e-06 0.04612731868611798 0.015375351137371384 8.285499948264298e-11 10.081681281062192 0.41965986387717824 GGVAGGSILK(ub)GVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGVAGGSILKGVLK 14 1 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 33513900.0 9717700.0 12401200.0 11395000.0 True False 12579754.214504711 11711062.318469083 9321226.922573557 1.0 0.9309452409623385 0.7409705121127084 23.5846003990695 -6.953380062615818 0.5204146164684962 1.0032178545550836 0.6602139627878714 0.9994405383381748 0.0025905064754153714 0.08215619259926382 0.030559897372791373 0.0029327795337928497 0.01569265868287655 1.1133198114662329e-07 6.953380062615818 -0.34300389176721224 GGVGWWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGVGWWK 7 0 Q96DZ1;Q96DZ1-3 Q96DZ1 ERLEC1 Endoplasmic reticulum lectin 1 0 8908500.0 1802000.0 3758900.0 3347600.0 False True 2362439.450592822 3198086.772077442 3001222.4644466676 1.0 1.3537222176318322 1.2703912744487702 21.171845922806497 -10.075382653614987 4.329264329988916 0.9999713632159387 1.3120567460000219 0.9492332161866088 0.0340197152564359 5017509.414974827 5838559.1491970075 1165.0666869341408 0.011645853545359535 8.406541211899612e-11 10.075382653614987 0.31208538278408315 GGVGWWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGVGWWK 7 0 Q96DZ1;Q96DZ1-3 Q96DZ1 ERLEC1 Endoplasmic reticulum lectin 1 0 5005300.0 1902500.0 1169000.0 1933800.0 False True 1842106.1788758484 1635787.7962544672 1427279.76724353 1.0 0.8879986479675739 0.7748086313431358 20.8129247899949 -6.970994196419013 0.23322699301814995 1.0442152225754793 0.6153452823435673 0.9999891273293344 0.00030308711160299015 0.07598141916862404 0.007866628841062057 0.0028404496786623603 0.011172766513647623 1.0690691653540392e-07 6.970994196419013 -0.42886994023191194 GGVGWWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGVGWWK 7 0 Q96DZ1;Q96DZ1-3 Q96DZ1 ERLEC1 Endoplasmic reticulum lectin 1 0 21530600.0 9046300.0 6382600.0 6101700.0 False True 13723898.473117394 5243575.162518593 4895696.320529884 1.0 0.3820762134600308 0.3567278153594372 23.710187022466037 GGVGWWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGVGWWK 7 0 Q96DZ1;Q96DZ1-3 Q96DZ1 ERLEC1 Endoplasmic reticulum lectin 1 0 10102100.0 1802000.0 4936000.0 3364100.0 False True 2468248.097218944 4717911.19883078 2569568.865814311 1.0 1.9114412380775678 1.041049669484007 21.23505598432939 -10.320842343582012 4.583603000235048 0.9996328514893273 1.4762454537821006 0.28529675196230164 0.35533586991696126 0.0013341898020730516 0.00019768786518679582 0.3443124429796491 0.11468415887424502 4.7770265652240803e-11 10.320842343582012 0.47661260229277325 GGVGWWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGVGWWK 7 0 Q96DZ1;Q96DZ1-3 Q96DZ1 ERLEC1 Endoplasmic reticulum lectin 1 0 22099200.0 9046300.0 7187300.0 5865600.0 False True 11710613.679232106 6787320.436855529 4798120.986138436 1.0 0.5795870842270489 0.40972412868913466 23.481313344558487 -13.999999999999998 0.12482262746014978 2.998757419611141 0.15542690669155299 0.9996696444143991 0.004509561441026283 11.947828527059636 0.10932366442609498 5.889418869680999 0.2258115038178824 1.0000000000000041e-14 13.999999999999998 -2.843330512919588 GGVK(ub)EALSER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGVKEALSER 10 1 B4E1Q4;O14730-2;O14730;J3QLP4 B4E1Q4 RIOK3 Serine/threonine-protein kinase RIO3 1 11278840.0 771540.0 2197600.0 8309700.0 True False 998773.7393270995 2075301.6281543418 6797419.864722194 1.0 2.0778496134194797 6.8057655073127945 19.929798363543718 -6.942762014657436 0.6333460854447056 0.9484031608934387 8.191486772586956 0.9985037632003765 0.09753486829018258 0.08652885654146014 0.04903888493626461 0.09706226963642317 0.4022328544722906 1.1408747945830728e-07 6.942762014657436 7.243083611693517 GGVQVPAVDISSSLGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGVQVPAVDISSSLGGR 17 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 55638000.0 11092000.0 24283000.0 20263000.0 False True 14541719.415080812 20660071.054392625 18166379.136420928 1.0 1.420744718328607 1.2492593632071516 23.79369452803244 -10.135391518193329 5.168179614246417 0.9999886081168392 1.3350020407682404 0.8357527048995602 0.07000860306918132 9.189685221399142e-06 1.5373594664379355e-06 0.06778784225601578 0.022595179481334396 7.321641866207445e-11 10.135391518193329 0.33501343265140116 GGVQVPAVDISSSLGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGVQVPAVDISSSLGGR 17 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 51730000.0 17088000.0 12537000.0 22105000.0 False True 16545550.793498283 17543089.47959131 16315037.364214625 1.0 1.060290448987955 0.9860679507040503 23.979939983291544 -6.690633668519769 1.8639303834457317 1.0377749316060085 0.9863207192869435 0.37352360271066887 0.02549520367695437 0.4152941733697032 2.7978279346358295 0.010939802247780132 0.028467726603659205 2.0387610667473975e-07 6.690633668519769 -0.051454212319064996 GGVQVPAVDISSSLGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGVQVPAVDISSSLGGR 17 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 77261000.0 14397000.0 48047000.0 14817000.0 False True 21841301.56168502 39472637.45707559 11888413.455478197 1.0 1.80724749143706 0.5443088371772394 24.380555495773233 -6.734061464319114 1.7084673858191568 1.483591577141743 0.5444939015476467 0.5779536311990707 0.3392533590261348 0.3286848056921106 1.8812954820153045 0.15724637475477712 0.3884081060498849 1.8447543184820372e-07 6.734061464319114 -0.9390976755940963 GGVQVPAVDISSSLGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGVQVPAVDISSSLGGR 17 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 48734000.0 11092000.0 16505000.0 21137000.0 False True 15193012.150029173 15775754.525263797 16144875.930179588 1.0 1.038355947423731 1.0626514196625971 23.85690458955533 GGVQVPAVDISSSLGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGVQVPAVDISSSLGGR 17 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 36536600.0 17088000.0 9523300.0 9925300.0 False True 14209429.126754928 9471996.092672948 12000634.340597851 1.0 0.666599341055731 0.8445542909251619 23.76034525872582 -10.049078008953042 4.875523367142223 1.000005648066911 0.755576817091531 0.71553562822391 0.07264980407398107 4.460378883367086e-06 8.69891136008096e-07 0.07034449579686498 0.023447623438859456 8.931450406002395e-11 10.049078008953042 -0.24442883097538004 GGVQVPAVDISSSLGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGVQVPAVDISSSLGGR 17 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 45248000.0 14397000.0 17486000.0 13365000.0 False True 18637200.30729742 16512888.728570664 10932707.136480533 1.0 0.8860176666183612 0.5866067304218336 24.151681817865683 -6.954392839958541 0.5083378553035617 1.0055866074209971 0.4539393838048776 0.9995024383075928 0.003888718455635669 0.08176832742036169 0.029022589767489507 0.0044920009016273755 0.02470846884863105 1.1107265678777983e-07 6.954392839958541 -0.5516472236161196 GGVTSAPQNGFWAVSLWYGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGVTSAPQNGFWAVSLWYGK 20 0 P14373;A0A140T9V9;H0Y551;A0A140T9B9;A0A140T9N6 P14373 TRIM27 Zinc finger protein RFP 0 52043000.0 14167000.0 12928000.0 24948000.0 False True 21492374.746432714 10620897.393074961 20017016.86490313 1.0 0.49417049155248927 0.9313543571180071 24.35732156278083 -10.20374689075512 7.8921771325296035 1.000000149303735 0.7127624243352486 0.3653063081051332 0.17847956573550594 4.689005433397527e-07 4.7311409203026155e-08 0.17281218656026923 0.05760403214432888 6.25537153100286e-11 10.20374689075512 -0.2872377249684863 GGVTSAPQNGFWAVSLWYGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGVTSAPQNGFWAVSLWYGK 20 0 P14373;A0A140T9V9;H0Y551;A0A140T9B9;A0A140T9N6 P14373 TRIM27 Zinc finger protein RFP 0 38103000.0 14167000.0 10786000.0 13150000.0 False True 18339460.773319628 10185749.61834398 10756834.930394229 1.0 0.555400714570751 0.5865404148655965 24.128447884873278 -9.941805193353098 5.3201250069071175 1.000001006371728 0.5709705647158382 0.9960644677213898 0.012712729419107957 1.51745996399877e-07 3.020152391907347e-08 0.012309076122613836 0.004103015775906079 1.1433910980105935e-10 9.941805193353098 -0.42903044165588977 GGVVGIK(ub)VDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGVVGIKVDK 10 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 79561000.0 24353000.0 27144000.0 28064000.0 True False 31927018.83478751 23094221.006483305 25160206.4888969 1.0 0.7233441094512703 0.7880537365262075 24.928274512670455 -9.923618827833257 5.277501188487779 1.0000005097091926 0.7556989229867296 0.9500107266198068 0.026417594636927125 1.5843630842267895e-07 3.2283455962011676e-08 0.025578779376326678 0.008526242005292525 1.1922879978757174e-10 9.923618827833257 -0.24430158672246305 GGVVGIK(ub)VDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGVVGIKVDK 10 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 170641000.0 33111000.0 34920000.0 102610000.0 True False 32059909.429045033 48863738.10539432 75733362.76598328 1.0 1.524138370182845 2.3622450629062537 24.934267014019277 -6.964173501953876 0.3719711256638121 0.9369721231255244 2.9786747892312526 0.9998950719353651 0.005746938721164103 0.07824263819805612 0.015856231024689662 0.01101488769847769 0.07110531640999491 1.0859916799941272e-07 6.964173501953876 2.0417026661057283 GGVVGIK(ub)VDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGVVGIKVDK 10 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 576128000.0 74838000.0 175850000.0 325440000.0 True False 113534717.39066365 144468193.57767892 261116641.354581 1.0 1.272458300843571 2.2998836598685495 26.75855828083233 -6.946230582307475 0.5987985173528083 0.9883963192654484 2.6364315512105225 0.9988712959657896 0.018804311013153673 0.08503558852039607 0.04250532041275408 0.019322577874362878 0.0863085808859387 1.1317992913932483e-07 6.946230582307475 1.6480352319450742 up GGVVGIK(ub)VDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGVVGIKVDK 10 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 74874000.0 24353000.0 21131000.0 29390000.0 True False 33356962.215079386 20197362.54912749 22448687.30604998 1.0 0.6054916637461983 0.6729835637101811 24.991484574193347 -10.69431389313767 6.757125695206204 1.0031021429252336 0.6392376137281974 0.9744218515600945 0.027553452780454013 0.0012957144303615447 5.861681515124158e-05 0.026845362524950865 0.008892838645767563 2.0215575381626423e-11 10.69431389313767 -0.36386452919703616 GGVVGIK(ub)VDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGVVGIKVDK 10 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 131786000.0 33111000.0 53122000.0 45553000.0 True False 27533263.5660102 52835821.242108546 55077921.68672533 1.0 1.918981420979616 2.0004138468611834 24.714672289453553 -10.99794134655947 0.4359497931242822 7.949412933056117e-14 2.0026469512047704 0.9996282811714774 0.008745905394452693 2.797471215680524 0.21241177014256435 2.8277981075355814 0.018954897836343763 1.004751477362007e-11 10.99794134655947 2.002646951204691 GGVVGIK(ub)VDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGVVGIKVDK 10 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 479418000.0 74838000.0 191830000.0 212750000.0 True False 96879266.27752486 181154491.86787757 174031682.9993437 1.0 1.8698995030467507 1.7963769719395317 26.529684602924778 -10.093668068520847 4.556037517851868 0.9999385573522067 1.8331382375120528 0.9941931738428873 0.030015447734447438 10440123.514335107 0.8457935985281567 6775.524867209134 0.01027508610876466 8.05994227617819e-11 10.093668068520847 0.8331996801598461 GGVVLK(ub)EDALPGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGVVLKEDALPGQK 14 1 P35613-2;P35613;A0A087X2B5;I3L192;A0A2R8YDZ0 P35613-2 BSG Basigin 1 14667200.0 301180.0 957020.0 13409000.0 True False 250444.51453628603 951864.3433064043 16212759.903788999 1.0 3.8006995085072703 64.73593535800916 17.93413148715874 -6.9146442059373765 0.8651606357797125 3.2523224210938147e-14 73.39612447076318 0.993208585369332 2.4234743043956235 0.09860154619601233 0.11988611928548358 2.0611921876722232 5.877243186862238 1.2171827645317925e-07 6.9146442059373765 73.39612447076316 up GGVYLHTSAK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGVYLHTSAKK 11 1 Q9HA65-3;Q9HA65;M0QXA2 Q9HA65-3 TBC1D17 TBC1 domain family member 17 1 6662600.0 1599100.0 2539100.0 2524400.0 True False 2096435.5857064263 2160276.1773342816 2263199.3037546766 1.0 1.0304519690770004 1.079546311456098 20.999507072482693 -6.964030759748144 0.37431301082230095 0.9964044653868208 1.1153143644493055 0.9998917212372446 0.00034095211826910084 0.07829138595288264 0.01602906654194147 0.0006431692929429957 0.004160131314990381 1.0863486781422182e-07 6.964030759748144 0.11890989906248473 GGVYLHTSAK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGVYLHTSAKK 11 1 Q9HA65-3;Q9HA65;M0QXA2 Q9HA65-3 TBC1D17 TBC1 domain family member 17 1 3550230.0 1534200.0 1444200.0 571830.0 True False 1986052.1436032294 1363829.00044617 467762.8074712803 1.0 0.6867035212740284 0.23552393071746522 20.921472070503775 -7.242564148733033 0.40418289078250347 1.0291807881930244 5.71286018230231e-11 0.9995876967734131 0.006371452345852452 0.09434309825520436 0.028692353927495515 0.010164577614892562 0.0476547513829454 5.720524517358787e-08 7.242564148733033 -1.0291807881358959 down GGVYLHTSAKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGVYLHTSAKK 11 1 Q9HA65-3;Q9HA65;M0QXA2 Q9HA65-3 TBC1D17 TBC1 domain family member 17 1 15811300.0 4138000.0 5854500.0 5818800.0 True False 5424958.072449006 4981031.420662257 5216726.393870903 1.0 0.9181695700025299 0.9616159837924608 22.37118055685297 -10.288543036463105 4.8202602358204265 1.0000223624035025 0.9398927768974301 0.7184700897600174 0.017736924156753313 4.264134434340165e-06 6.293733703422126e-07 0.01718009120652262 0.005724567655971658 5.145848116442353e-11 10.288543036463105 -0.06012958550607239 GGVYLHTSAKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGVYLHTSAKK 11 1 Q9HA65-3;Q9HA65;M0QXA2 Q9HA65-3 TBC1D17 TBC1 domain family member 17 1 15135900.0 4138000.0 5122900.0 5875000.0 True False 5667930.425245285 4896553.338835137 4487445.999423048 1.0 0.8639049832061468 0.7917256675268469 22.43439061837586 -13.999999999865619 0.07912226121351872 1.7378190448181248 0.5726383555141905 0.9998902753986242 0.0009045138401216114 12.26722174958068 0.07888902874988567 1.590591221694111 0.19918664133402608 1.0000000003094245e-14 13.999999999865619 -1.1651806893039343 GGVYLHTSAKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGVYLHTSAKK 11 1 Q9HA65-3;Q9HA65;M0QXA2 Q9HA65-3 TBC1D17 TBC1 domain family member 17 1 18300400.0 6573600.0 8476800.0 3250000.0 True False 5466239.659856993 8431133.79588694 3929559.9736978253 1.0 1.5424010509095596 0.7188780986965783 22.38211728357744 -6.728999237163885 1.7264042870188516 1.3267571242198095 0.7194094037462029 0.5549076009264147 0.22802981575377307 0.33807825001166036 1.973492938984006 0.10468096055733465 0.2601006091715108 1.866382969124269e-07 6.728999237163885 -0.6073477204736066 GGWFSGLWGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGWFSGLWGK 10 0 Q709C8-3;Q709C8;Q709C8-4;Q709C8-2 Q709C8-3 VPS13C Vacuolar protein sorting-associated protein 13C 0 8371300.0 1929600.0 2089800.0 4351900.0 False True 2529724.286272981 1778009.9859766003 3901607.1343725217 1.0 0.7028473401724444 1.542305284233454 21.270548724005682 -6.8110161153294255 1.4100884254458463 0.8382402266741499 1.5573563366863519 0.862479366961603 0.12888260364434595 0.20543554870239386 0.8048541672523394 0.07186102455008465 0.16616726500363815 1.5451971009735478e-07 6.8110161153294255 0.719116110012202 GGWFSGLWGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGWFSGLWGK 10 0 Q709C8-3;Q709C8;Q709C8-4;Q709C8-2 Q709C8-3 VPS13C Vacuolar protein sorting-associated protein 13C 0 12830900.0 4154600.0 1939700.0 6736600.0 False True 4022714.4971130625 2714232.325401874 4972082.366331965 1.0 0.6747265627102712 1.2360018017436298 21.939737918966713 -6.74958034143232 1.6513076975764474 0.8086378446664152 1.2370868554511918 0.6471733484899751 0.13667980687726483 0.30079143675933734 1.6136059163336443 0.06538754367685179 0.15881888575075592 1.7799985911423155e-07 6.74958034143232 0.4284490107847766 GGWFSGLWGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGWFSGLWGK 10 0 Q709C8-3;Q709C8;Q709C8-4;Q709C8-2 Q709C8-3 VPS13C Vacuolar protein sorting-associated protein 13C 0 11214200.0 1929600.0 3265400.0 6019200.0 False True 2643025.265479288 3121123.830766217 4597588.929315279 1.0 1.1808906526666252 1.7395175859136365 21.333758785528573 -6.95079738513065 0.5500196184845599 0.9922752584301526 1.9543773553744812 0.9992623843508177 0.008548623856638982 0.08316712365684611 0.03464935987924224 0.009278237867463717 0.04634300816059823 1.119960265599637e-07 6.95079738513065 0.9621020969443286 GGWFSGLWGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGWFSGLWGK 10 0 Q709C8-3;Q709C8;Q709C8-4;Q709C8-2 Q709C8-3 VPS13C Vacuolar protein sorting-associated protein 13C 0 7438500.0 4154600.0 1002000.0 2281900.0 False True 3454733.979986895 996602.0271185732 2759034.739686487 1.0 0.28847431752830754 0.7986243675112006 21.72014319440099 -9.940095661627918 6.434652910524763 1.0000000690680653 0.5435493425206586 0.5163025908161217 0.20826788578563152 2.0631949869555332e-07 3.385642225224077e-08 0.20165454184557413 0.06721817109978927 1.1479007466539936e-10 9.940095661627918 -0.4564507265474067 GGWVYVLHPTPELWTLNLPHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGWVYVLHPTPELWTLNLPHR 21 0 Q96FX7 Q96FX7 TRMT61A tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 0 19411800.0 10571700.0 2390100.0 6450000.0 False True 10236107.17015601 3344479.394206841 4760551.504147673 1.0 0.3267335265849769 0.4650744101260828 23.28716382153186 -9.915216248116897 6.876613665397624 1.0000000209636584 0.39590396836000474 0.9621560963294437 0.05647742920693351 1.8162297623694396e-08 2.8439196219347893e-09 0.05468403772589099 0.01822801189625269 1.2155805762695475e-10 9.915216248116897 -0.6040960526036536 GGWVYVLHPTPELWTLNLPHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGWVYVLHPTPELWTLNLPHR 21 0 Q96FX7 Q96FX7 TRMT61A tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 0 40471300.0 7689900.0 6055400.0 26726000.0 False True 11666140.506994642 4974766.558943854 21443594.38557809 1.0 0.4264277938330285 1.8381052733525025 23.47582401939936 -6.796409903992067 1.4706218814937866 0.682081024520293 1.8558872061396792 0.8214303543382908 0.24495742401438475 0.2259235783400991 0.9649837873327695 0.13106447765281387 0.3054854403760054 1.598049015894131e-07 6.796409903992067 1.173806181619386 GGWVYVLHPTPELWTLNLPHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGWVYVLHPTPELWTLNLPHR 21 0 Q96FX7 Q96FX7 TRMT61A tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 0 21812000.0 10571700.0 5562700.0 5677600.0 False True 8790836.95571835 5532732.630990504 6864759.909743623 1.0 0.6293749569990055 0.7808994688814205 23.067569096966135 -10.113087220517764 5.145811780938298 1.0000080488482492 0.7051372140935134 0.834685803965067 0.06185962294097789 5.7122638618875665e-06 9.845215247287429e-07 0.05989695691363232 0.01996510745419168 7.707486620127221e-11 10.113087220517764 -0.29487083475473586 GGWVYVLHPTPELWTLNLPHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGWVYVLHPTPELWTLNLPHR 21 0 Q96FX7 Q96FX7 TRMT61A tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A 0 25672300.0 7689900.0 9794400.0 8188000.0 False True 9954727.140590861 9249333.030030439 6697868.015974748 1.0 0.9291397844864933 0.6728329085650053 23.24695034149181 -6.947189170199193 0.588901110168858 1.0029723521797465 0.5861278022709269 0.998961779321143 0.004528259652406429 0.08463460144844591 0.04078874393398156 0.004699943841895722 0.0214650718891224 1.1293039047879207e-07 6.947189170199193 -0.4168445499088196 GGYVLHIGTIYGDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GGYVLHIGTIYGDLK 15 0 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 95215000.0 12141000.0 83074000.0 0.0 False True 15916968.573611254 70679683.01991574 0.0 1.0 4.440524129518959 0.0 23.92406226138354 -6.699993674038301 1.8315718473623697 3.1367680029812535 0.013762846865860538 0.4168780310578758 1.4523469289875945 0.3957520028960121 2.58122658376656 0.6326850829488982 1.6267012647707273 1.9952913783013346e-07 6.699993674038301 -3.123005156115393 GGYVLHIGTIYGDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GGYVLHIGTIYGDLK 15 0 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 269072000.0 89146000.0 69396000.0 110530000.0 False True 86316109.02605337 97106184.69535913 81578877.17107627 1.0 1.1250065114270722 0.9451176390081806 26.363126496422336 -6.719842954699972 1.7601644534949867 1.076066348731683 0.9454059441454152 0.5116579450571934 0.05260419675470449 0.3556176331349884 2.1531887362021043 0.023732128524929015 0.05958113607670674 1.906149876527103e-07 6.719842954699972 -0.13066040458626782 GGYVLHIGTIYGDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GGYVLHIGTIYGDLK 15 0 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 548630000.0 160580000.0 159520000.0 228530000.0 False True 243611599.97050643 131052409.66455121 183360945.33174276 1.0 0.5379563603720737 0.7526773985883345 27.860007590296675 -10.077428248112989 4.873837146715502 1.0000102102324913 0.6453168794787429 0.7843928935800767 0.08765949679156182 121764438.12611945 5.014728238298759 15451.943440254028 0.030008177355673762 8.367038202127203e-11 10.077428248112989 -0.3546933307537483 GGYVLHIGTIYGDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GGYVLHIGTIYGDLK 15 0 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 173011000.0 12141000.0 72003000.0 88867000.0 False True 16629855.798188252 68821669.3779199 67878444.87331545 1.0 4.13844053809641 4.081721795850479 23.98727232290643 -10.18205519715607 4.326755493689337 0.9991033728027682 4.110081167085303 0.999750619364406 0.023155330057053548 851778.2847414686 1002307.7785033761 5931.38855879899 0.00792668525110527 6.575742568885936e-11 10.18205519715607 3.110977794282535 GGYVLHIGTIYGDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GGYVLHIGTIYGDLK 15 0 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 176360000.0 89146000.0 37112000.0 50102000.0 False True 74128848.83741201 36912070.28984472 60578096.55452576 1.0 0.4979447390422122 0.8172000173291868 26.143531771856612 -10.08210308398822 5.179510986520987 1.000006029921088 0.6575723781850433 0.605353137126007 0.13033542158451955 9.07564920794717e-06 1.6084163305216525e-06 0.12619895138294482 0.04206557643448346 8.277456669674458e-11 10.08210308398822 -0.3424336517360447 GGYVLHIGTIYGDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GGYVLHIGTIYGDLK 15 0 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 512360000.0 160580000.0 196670000.0 155110000.0 False True 207873975.5050233 185725141.61317578 126881571.56299978 1.0 0.8934506648172883 0.6103773753051337 27.631133912389124 -6.9541458764986555 0.5113086993804531 1.005154170165133 0.4862272999241688 0.9994877476700444 0.003721186737038599 0.08186247577805715 0.029394079499562877 0.004276459863055104 0.02336481089771393 1.1113583670276419e-07 6.9541458764986555 -0.5189268702409642 GHAGSVDSIAVDGSGTK(ub)FCSGSWDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHAGSVDSIAVDGSGTKFCSGSWDK 25 1 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 1 44914400.0 9915400.0 7460000.0 27539000.0 True False 15042386.712838216 6128704.714753967 22095904.57922749 1.0 0.4074290092225395 1.4689094889688823 23.842530155801178 -6.755230192517944 1.630651623853015 0.65375806728079 1.4718666367538493 0.6710767996709204 0.24909430683017872 0.29102102013424386 1.5240066042093867 0.12059930200167168 0.29117436129870944 1.7569920947797398e-07 6.755230192517944 0.8181085694730593 GHAGSVDSIAVDGSGTK(ub)FCSGSWDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHAGSVDSIAVDGSGTKFCSGSWDK 25 1 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 1 52990800.0 9915400.0 18120400.0 24955000.0 True False 12835680.761754323 17111983.81088825 20413446.059923034 1.0 1.333157479412838 1.590367230131471 23.613656477893628 -6.974011262253125 0.13065261175553225 0.6054095920847095 2.32477536789544 0.9999992029724356 0.00021568619705955423 0.07502133860803775 0.00392450948143962 0.016067425240451804 0.03502468491325596 1.0616680253520882e-07 6.974011262253125 1.7193657758107306 GHALLILRPEELGFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHALLILRPEELGFLR 16 1 Q9NVP1;H7C452 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 46692200.0 15556700.0 15922400.0 15213100.0 False True 15062861.073807068 22280297.35421908 11228332.726782775 1.0 1.4791544079871035 0.74543160637044 23.8444924889996 -6.73050575846251 1.7215824189137174 1.2881910511091788 0.745842832624207 0.5615483681011757 0.20141653875348403 0.3352780116374834 1.9470438124271208 0.09270930419057183 0.22990298689677569 1.8599199017302538e-07 6.73050575846251 -0.5423482184849717 GHALLILRPEELGFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHALLILRPEELGFLR 16 1 Q9NVP1;H7C452 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 215152000.0 73271000.0 68615000.0 73266000.0 False True 111157463.82761863 56370117.1585581 58784942.98637146 1.0 0.5071194971304496 0.5288438667288621 26.728029582547617 -10.044537166673825 4.958077650094449 1.0000086686424003 0.517981681926067 0.9984788655386295 0.008868936764782823 8.653649904516423e-07 1.6675529255583045e-07 0.008587468265965697 0.0028624370302588625 9.025324659526944e-11 10.044537166673825 -0.48202698671633337 GHALLILRPEELGFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GHALLILRPEELGFLR 16 1 Q9NVP1;H7C452 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 28465300.0 15556700.0 6036400.0 6872200.0 False True 12936085.328662733 6003880.7150684185 8309145.246537292 1.0 0.46411882439933394 0.6423230085013865 23.624897764433875 -10.158690445631368 6.1338428532686216 1.00000308767965 0.5532209164503581 0.893399969926746 0.07275155351318092 3.0718775415060305e-06 4.2140299363306904e-07 0.0704418751740867 0.023480462930604084 6.939202389747855e-11 10.158690445631368 -0.44678217122929187 GHALLILRPEELGFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHALLILRPEELGFLR 16 1 Q9NVP1;H7C452 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 187852600.0 73271000.0 72373000.0 42208600.0 False True 94850753.88733703 68345378.92901996 34527067.89680899 1.0 0.7205570449150046 0.36401469130988634 26.499155904640066 -6.967806435077951 0.30607985596343534 1.0575341467090096 0.01576804653746847 0.9999598633714369 0.0016489230809528996 0.07702109030597494 0.011564495644845673 0.005744025224310559 0.03177679084119206 1.0769451007917944e-07 6.967806435077951 -1.041766100171541 down GHAVGDIPGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHAVGDIPGVR 11 0 P62266;D6RD47 P62266 RPS23 40S ribosomal protein S23 0 7885100.0 2069900.0 1271100.0 4544100.0 False True 2004192.1575059749 1778656.8586989301 3353863.88992208 1.0 0.8874682260568758 1.6734243158079425 20.934589406894556 -6.870587392624106 1.130931881992956 0.9361189635648711 1.7199808834854338 0.9652685597811708 0.0646744705045617 0.136295583022454 0.32544309429537616 0.04436412377734802 0.1051464420570786 1.3471396145727867e-07 6.870587392624106 0.7838619199205626 GHAYSVTGAK(ub)QVNYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHAYSVTGAKQVNYR 15 1 P07384;E9PL37 P07384 CAPN1 Calpain-1 catalytic subunit 1 4819150.0 830650.0 1024300.0 2964200.0 True False 804281.4704248217 1433308.3316539333 2187787.09590613 1.0 1.7820979151699956 2.720175928895316 19.617340957086725 -6.968706555483557 0.2874049046050355 0.81092253844455 3.720229610179529 0.9999704626753573 0.0038218765818818596 0.07672466506275226 0.010524945377572563 0.016621090014662845 0.08532784650753089 1.0747153317656194e-07 6.968706555483557 2.909307071734979 GHAYSVTGAK(ub)QVNYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GHAYSVTGAKQVNYR 15 1 P07384;E9PL37 P07384 CAPN1 Calpain-1 catalytic subunit 1 4967950.0 830650.0 2204800.0 1932500.0 True False 690722.2790343508 2192922.3047814635 2336576.8151295558 1.0 3.17482492072969 3.382802156600705 19.397746232521 -10.255994262566022 0.5038186984827775 4.0994554170245206e-22 3.375210096974918 0.9994662002362983 0.02489682817518178 1.583199184208596 0.2358681773770516 2.2588776507988664 0.04186430225242018 5.546330401277527e-11 10.255994262566022 3.375210096974918 GHEGPVWQVAWAHPMYGNILASCSYDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHEGPVWQVAWAHPMYGNILASCSYDR 27 0 P55735;P55735-2;P55735-4;P55735-3;A8MXL6;E7ERC8 P55735 SEC13 Protein SEC13 homolog 0 15715200.0 8599500.0 3088100.0 4027600.0 False True 8326513.579628319 4321194.4342287555 2972650.7345899483 1.0 0.518968040213254 0.3570102547917351 22.98928111602376 -13.999999999999998 0.1520352150801604 3.33358262751136 0.18292753706318335 0.9995595889167379 0.005730435598455301 11.965962713689473 0.12290100244373847 8.244707086073543 0.1572265335505454 1.0000000000000041e-14 13.999999999999998 -3.1506550904481765 GHEGPVWQVAWAHPMYGNILASCSYDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHEGPVWQVAWAHPMYGNILASCSYDR 27 0 P55735;P55735-2;P55735-4;P55735-3;A8MXL6;E7ERC8 P55735 SEC13 Protein SEC13 homolog 0 184335100.0 51292900.0 55130700.0 77911500.0 False True 77815079.31328438 45292195.84687487 62512257.87517648 1.0 0.5820490867140028 0.803343753252521 26.213546417655508 -10.561720260795164 7.778854405180244 1.000119742254657 0.6926964199833267 0.719980324452828 0.09034316930312072 0.0001876866419103201 1.0574720276051534e-05 0.08750807896086153 0.02915813251288199 2.743340652648343e-11 10.561720260795164 -0.3074233222713304 GHEGPVWQVAWAHPMYGNILASCSYDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GHEGPVWQVAWAHPMYGNILASCSYDR 27 0 P55735;P55735-2;P55735-4;P55735-3;A8MXL6;E7ERC8 P55735 SEC13 Protein SEC13 homolog 0 18171700.0 8599500.0 2171200.0 7401000.0 False True 7150865.272444359 2159503.314650542 8948514.881642345 1.0 0.30199188942520316 1.251389103375388 22.769686391458038 -6.709704734489539 1.7965252574893678 0.5707470646664389 1.2491145110462734 0.4636062665865882 0.2941501229014897 0.37565421913105435 2.363293398479732 0.1303142113368119 0.3311447319912396 1.9511706990721678e-07 6.709704734489539 0.6783674463798345 GHEGPVWQVAWAHPMYGNILASCSYDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHEGPVWQVAWAHPMYGNILASCSYDR 27 0 P55735;P55735-2;P55735-4;P55735-3;A8MXL6;E7ERC8 P55735 SEC13 Protein SEC13 homolog 0 150874300.0 51292900.0 53093400.0 46488000.0 False True 66399670.184217356 50138705.617150486 38027661.007160954 1.0 0.7551047388947428 0.5727085827634097 25.984672739747957 -7.093074800978809 0.11837692650599255 1.3447418307332748 3.430622774729108e-12 0.9999993830523052 0.00013738288529374583 0.07591450136810647 0.003924405443898757 0.015074888083871786 0.028653537090067686 8.070960075965988e-08 7.093074800978809 -1.3447418307298442 GHEGPVWQVAWAHPMYGNILASCSYDRK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHEGPVWQVAWAHPMYGNILASCSYDRK 28 1 P55735;P55735-2;P55735-4;P55735-3;A8MXL6;E7ERC8 P55735 SEC13 Protein SEC13 homolog 0 68508000.0 10400000.0 18013000.0 40095000.0 False True 15777560.341843726 14798439.413788635 32170205.675737202 1.0 0.9379421845430462 2.03898479731486 23.9113708052517 -6.8935538818247295 1.0011487453859116 0.9457806723288628 2.140540779456388 0.9830763238584749 0.06570184340004637 0.1163060050665807 0.20539572084279245 0.04975711320428646 0.12573895833252344 1.2777506724176586e-07 6.8935538818247295 1.1947601071275251 up GHEGPVWQVAWAHPMYGNILASCSYDRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHEGPVWQVAWAHPMYGNILASCSYDRK 28 1 P55735;P55735-2;P55735-4;P55735-3;A8MXL6;E7ERC8 P55735 SEC13 Protein SEC13 homolog 0 73452000.0 10400000.0 35444000.0 27608000.0 False True 13463005.014648408 33471510.24221998 22583627.282001812 1.0 2.4861841918502847 1.6774581348985402 23.68249712734415 -10.009568208064703 5.188031420154157 0.9999921338139072 2.0818211633791623 0.7046549498826085 0.33016103022070253 3.0040231936821542e-05 5.734132419995294e-06 0.3196793646046891 0.10655901429857106 9.782093101806095e-11 10.009568208064703 1.081829029565255 GHFGPIHCVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GHFGPIHCVR 10 0 Q9Y3F4;Q9Y3F4-2;H0YH33 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 0 3853100.0 1069900.0 0.0 2783200.0 False True 1402649.2609263395 0.0 2495221.1623395756 1.0 0.0 1.7789345004835195 20.419722870668316 -6.754169224038197 1.6342403528590856 0.414944616788936 1.7836596143131467 0.6667466622989275 0.4203262336044534 0.2928475187474711 1.5399799689064193 0.2030646042583156 0.4908814691237211 1.7612896213461042e-07 6.754169224038197 1.3687149975242106 GHFGPIHCVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHFGPIHCVR 10 0 Q9Y3F4;Q9Y3F4-2;H0YH33 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 0 4063700.0 1069900.0 2993800.0 0.0 False True 1465470.942960351 2861524.0168273062 0.0 1.0 1.952631016379508 0.0 20.482932932191208 -6.780827993682817 1.577238926494298 1.5432094879590044 1.1698819120662216e-19 0.7455045486225724 0.40218619887804147 0.2552227557265517 1.261232365974549 0.2022745217994915 0.4682940698533112 1.6564258762481497e-07 6.780827993682817 -1.5432094879590044 GHFGPINSVAFHPDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GHFGPINSVAFHPDGK 16 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 26156000.0 7600300.0 10795000.0 7760700.0 False True 9964066.901409898 9184428.078580419 6957697.2098910315 1.0 0.9217549590399516 0.6982788532769214 23.248303277575772 -6.952550112563642 0.5301079447391798 1.0035218253582323 0.6063651585044698 0.9993865146714767 0.0031665454249428485 0.08247760805376056 0.03184726648736832 0.0035321909689330455 0.018480544256444003 1.1154494339524151e-07 6.952550112563642 -0.3971566668537625 GHFGPINSVAFHPDGK(ub)SYSSGGEDGYVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GHFGPINSVAFHPDGKSYSSGGEDGYVR 28 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 43344100.0 11197400.0 11318700.0 20828000.0 True False 14679899.835775854 9629994.07994705 18672918.35628367 1.0 0.6559986231294399 1.272005842354358 23.807338788596855 -6.75511662231504 1.6305523583899046 0.798982490714211 1.2737537622261381 0.6708659139830337 0.14460492391822213 0.2911847314956507 1.524559240379683 0.07000876447701562 0.16908337528900885 1.757451617177352e-07 6.75511662231504 0.4747712715119271 GHFGPINSVAFHPDGK(ub)SYSSGGEDGYVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHFGPINSVAFHPDGKSYSSGGEDGYVR 28 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 120683300.0 6870300.0 10954000.0 102859000.0 True False 6652206.087112093 15327989.32435537 75917142.1961435 1.0 2.304196400958118 11.412325655878954 22.6654014337174 -6.932713766939651 0.724168960521597 0.8744775452183058 13.41832455322887 0.9970452607142375 0.25176878346413384 0.0912529839964268 0.07095493049965575 0.23319460060695277 0.8121807168605341 1.1675788867260607e-07 6.932713766939651 12.543847008010566 GHFGPINSVAFHPDGK(ub)SYSSGGEDGYVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHFGPINSVAFHPDGKSYSSGGEDGYVR 28 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 615208000.0 27931000.0 45087000.0 542190000.0 True False 42373369.029619 37040872.58366116 435025908.8496813 1.0 0.8741545322433432 10.266493290764727 25.336654503536298 -6.9038655083675895 0.936522052419474 0.649828592009852 11.33351726742783 0.9883928566967378 0.47384958821906736 0.10861513990096194 0.16181356946730752 0.37654536163119623 1.0001253131888244 1.247769861827317e-07 6.9038655083675895 10.683688675417978 up GHFGPINSVAFHPDGK(ub)SYSSGGEDGYVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHFGPINSVAFHPDGKSYSSGGEDGYVR 28 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 59799600.0 11197400.0 7077200.0 41525000.0 True False 15337381.378357066 6764505.902829257 31717650.23421999 1.0 0.44104699074477 2.0679964494445904 23.870548850119746 -6.813958107000145 1.3978156808445963 0.6967675696311723 2.0991143564512242 0.8699134450730042 0.2434374436738838 0.20145313731925607 0.7749946270959324 0.1369094820267594 0.31617286883928214 1.5347650224649584e-07 6.813958107000145 1.4023467868200519 up GHFGPINSVAFHPDGK(ub)SYSSGGEDGYVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GHFGPINSVAFHPDGKSYSSGGEDGYVR 28 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 89142300.0 6870300.0 24641000.0 57631000.0 True False 5712958.855895632 24508254.042144433 69681375.64436291 1.0 4.289940582514877 12.197072900753252 22.445806709151675 -6.956300704209422 0.4847708692902824 0.8184706239040896 16.000880100431335 0.9996074228745062 0.09310285607757199 0.08105011884574824 0.026223240652179666 0.11258946808840851 0.6521876004045615 1.1058578261603552e-07 6.956300704209422 15.182409476527246 GHFGPINSVAFHPDGK(ub)SYSSGGEDGYVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHFGPINSVAFHPDGKSYSSGGEDGYVR 28 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 873729000.0 27931000.0 91258000.0 754540000.0 True False 36157230.10232164 86179412.0777708 617221462.2341946 1.0 2.3834627772617254 17.070485224877974 25.107780825628748 -6.925238322958277 0.7848880412499423 0.7329153274405532 19.749975214115775 0.995516856503122 0.486878058351819 0.09518669049799998 0.09035142564167148 0.43159064915976675 1.3653631671727189 1.1878502051905474e-07 6.925238322958277 19.01705988667522 GHFYMHAGSLLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GHFYMHAGSLLLK 13 0 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 0 14598900.0 4517700.0 4506900.0 5574300.0 False True 5922748.449469027 3834488.0877586077 4997524.9084613025 1.0 0.6474170092606868 0.8437847649783825 22.49783538272195 -10.127966877974725 5.161353495559815 1.0000080286844626 0.7456008871192249 0.691152388516589 0.08016680057505432 7.406597907474125e-06 1.2514385214294674e-06 0.07762361999639877 0.025873723628671175 7.447887740104026e-11 10.127966877974725 -0.2544071415652377 GHFYMHAGSLLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHFYMHAGSLLLK 13 0 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 0 11148700.0 2881300.0 2073000.0 6194400.0 False True 2789834.708643884 2900759.710552188 4571900.811983308 1.0 1.0397604207749727 1.6387712138708288 21.411748217513445 -6.920369541346438 0.8219622404116926 0.986959674334552 1.7361994907249476 0.9942836128884841 0.022092245515905003 0.0979539895894914 0.10448388482920372 0.01907231330365958 0.05733570832116522 1.2012418624496668e-07 6.920369541346438 0.7492398163903956 GHFYMHAGSLLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHFYMHAGSLLLK 13 0 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 0 24109800.0 3874100.0 8068700.0 12167000.0 False True 5877292.934647771 6628777.443959151 9762187.117014455 1.0 1.1278623539216899 1.66100060445592 22.486720375908703 -6.943922061889092 0.6220133677407046 0.9941722636045967 1.8230327698690831 0.9986337301209463 0.01058107989502554 0.08602218875124111 0.04679895085714794 0.010636475780914128 0.04515405913359483 1.1378314617491555e-07 6.943922061889092 0.8288605062644865 GHFYMHAGSLLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHFYMHAGSLLLK 13 0 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 0 16969800.0 4517700.0 4229500.0 8222600.0 False True 6188015.776251953 4042626.704913853 6280591.229762718 1.0 0.6532993533126462 1.0149604423870486 22.56104544424484 -10.983474346221753 11.949248868371946 1.105268627936172 0.8341298978498624 0.21903084162584752 0.1476475213419237 0.07269034037744274 0.00010052976982191852 0.025096966287603332 0.047653032605506206 1.0387849616457004e-11 10.983474346221753 -0.27113873008630973 GHFYMHAGSLLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHFYMHAGSLLLK 13 0 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 0 27974100.0 3874100.0 12966000.0 11134000.0 False True 5015098.819927829 12244430.70196997 9107726.244487392 1.0 2.4415133463204968 1.816061172772356 22.257846698001153 -9.97886033111504 5.52787043436275 0.9999974420984111 2.1287872595479325 0.812833936817017 0.2553397806232405 8.049732079923524e-06 1.486852595013767e-06 0.24723223919645435 0.08241055983073575 1.0498800152456243e-10 9.97886033111504 1.1287898174495212 GHGEWAEAMLPTLGK(ub)VGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 GHGEWAEAMLPTLGKVGR 18 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 36627100.0 8487800.0 11214200.0 16925100.0 True False 11127587.995972117 9541085.07260922 15173853.00902324 1.0 0.857426162440848 1.3636246250773987 23.40763757375037 -6.831510809691659 1.3213306058508778 0.9238971267985425 1.377653155775025 0.9088280072529981 0.06435140484381284 0.17895598820265826 0.6105486913511938 0.038234619484830555 0.08797813945998649 1.4739718530116075e-07 6.831510809691659 0.4537560289764824 GHGEWAEAMLPTLGK(ub)VGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHGEWAEAMLPTLGKVGR 18 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 71518800.0 18995700.0 19466100.0 33057000.0 True False 18392691.90122047 27239015.24437045 24398380.011257295 1.0 1.4809694736724737 1.326525782212353 24.132629308090358 -9.984010053439482 4.7105759684168955 0.9999946140980798 1.4037476277854624 0.9011085473154478 0.06305137308982221 43728145.81392603 43765946.303735 3746.707021872602 0.023074439733750528 1.0375043984545768e-10 9.984010053439482 0.4037530136873826 GHGEWAEAMLPTLGK(ub)VGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHGEWAEAMLPTLGKVGR 18 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 68772200.0 15824200.0 40775000.0 12173000.0 True False 24006468.30398113 33498382.673470937 9767001.21438457 1.0 1.3953898694842886 0.40684873304603714 24.51691984224469 -6.7981576602061144 1.4633812401128308 1.2186708966097606 0.39380930300307093 0.8267228802993019 0.16910927693390546 0.22340400270843128 0.9446853041079635 0.09091833578146258 0.21168818178482132 1.5916308187257984e-07 6.7981576602061144 -0.8248615936066896 down GHGEWAEAMLPTLGK(ub)VGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHGEWAEAMLPTLGKVGR 18 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 35444200.0 5043600.0 12836500.0 17564100.0 True False 6908355.218165078 12269340.985371009 13415821.323994298 1.0 1.7760147817977803 1.9419703967622066 22.71991083550162 -11.009248171994761 0.29130012866498745 4.1585353851796947e-10 1.9956557562866053 0.9992371289102278 0.011339763342136334 2.9133003744371067 0.150256446869339 2.013769220490326 0.06201313360895068 9.78930428348122e-12 11.009248171994761 1.9956557558707517 GHGEWAEAMLPTLGK(ub)VGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GHGEWAEAMLPTLGKVGR 18 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 53079900.0 18995700.0 19480900.0 14603300.0 True False 15795766.202194443 19375952.52504411 17656782.511969715 1.0 1.2266548059157958 1.1178174129670726 23.913034583524635 -10.238354168908785 4.06182045383185 0.9998636087847625 1.1722361094589142 0.7695380557698926 0.044432679688935925 31352663.589655474 9.899466233752332 40706.20278634312 0.015210488085691655 5.776247999161375e-11 10.238354168908785 0.17237250067415166 GHGEWAEAMLPTLGK(ub)VGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHGEWAEAMLPTLGKVGR 18 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 73940000.0 15824200.0 50388000.0 7727800.0 True False 20484738.841615338 47583863.50538824 6321419.693923993 1.0 2.322893343835082 0.3085916663522137 24.28804616433714 -6.7295460185336164 1.7247582989742247 1.7965306344350116 0.30987298934000734 0.5571409896664586 0.5561366611604375 0.33712868508334753 1.9645180810943923 0.2555370141643301 0.6344546937215214 1.86403465171298e-07 6.7295460185336164 -1.4866576450950042 GHISHLEREIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GHISHLEREIQK 12 1 Q6PKC3;Q6PKC3-2 Q6PKC3 TXNDC11 Thioredoxin domain-containing protein 11 0 89050000.0 30962000.0 43472000.0 14616000.0 False True 40591481.83643453 36986147.052528776 13103676.52657201 1.0 0.9111800155896345 0.32281838291526166 25.274673672368674 -6.933779242423483 0.7150980564859034 1.0078155994194427 0.18952381981115893 0.9972301238503487 0.0158145271327188 0.09072270711006344 0.06841330911278155 0.014746485935432005 0.05217470235756163 1.164717920347156e-07 6.933779242423483 -0.8182917796082837 down GHISHLEREIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHISHLEREIQK 12 1 Q6PKC3;Q6PKC3-2 Q6PKC3 TXNDC11 Thioredoxin domain-containing protein 11 0 141882000.0 61002000.0 49096000.0 31784000.0 False True 59065524.90080665 68700288.83225775 23458816.900438715 1.0 1.1631199239764907 0.39716597693552946 25.8158129745303 -6.851021590236538 1.2300540385183458 1.0871342253705922 0.3659216768127234 0.9417871085960704 0.07948212343213626 0.15634135846106745 0.45467219601853665 0.05054694116963604 0.11705442947831773 1.4092187396864368e-07 6.851021590236538 -0.7212125485578689 down GHISHLEREIQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHISHLEREIQK 12 1 Q6PKC3;Q6PKC3-2 Q6PKC3 TXNDC11 Thioredoxin domain-containing protein 11 0 142924000.0 41294000.0 24597000.0 77033000.0 False True 62646016.99577834 20207473.172761835 61807393.78523667 1.0 0.3225659689445795 0.986613303594414 25.900719450804054 -10.83554887353548 10.782568801978455 1.0058227719012875 0.65458963631901 0.26511341695785207 0.2710961891578797 0.03779716737931782 0.0005764654805141093 0.2614512442491126 0.08749591881906364 1.4603304012200585e-11 10.83554887353548 -0.35123313558227753 GHISHLEREIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHISHLEREIQK 12 1 Q6PKC3;Q6PKC3-2 Q6PKC3 TXNDC11 Thioredoxin domain-containing protein 11 0 90889000.0 30962000.0 40138000.0 19789000.0 False True 42409488.11658881 38364570.4413837 15115245.767248133 1.0 0.9046223414891228 0.35641188890784287 25.337883733891566 -6.936751122695437 0.6891304866681376 1.006634353647303 0.22171470129034754 0.997706559181303 0.013581349985850573 0.08928072549860193 0.06159778727674718 0.012915077356306717 0.04789768296264529 1.1567749550973424e-07 6.936751122695437 -0.7849196523569555 down GHISHLEREIQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHISHLEREIQK 12 1 Q6PKC3;Q6PKC3-2 Q6PKC3 TXNDC11 Thioredoxin domain-containing protein 11 0 177635000.0 41294000.0 33881000.0 102460000.0 False True 53455897.02643184 31995492.566207357 83813331.32837956 1.0 0.5985399992518475 1.5678968269288822 25.671845772896503 -6.794227090931654 1.4793717905273078 0.7768528690994027 1.5794463054550956 0.8147474551747869 0.17116445303214783 0.22910139085058767 0.9903691131638902 0.09104897220480151 0.21253337251305765 1.6061012091947263e-07 6.794227090931654 0.8025934363556929 GHK(ub)GGILDTAIVDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHKGGILDTAIVDR 14 1 F5H0C4;Q9BRP4-2;Q9BRP4;F5H3I1;F5H103;Q9BRP4-3;F5H0F7;F5H3E9;H0YGB1 F5H0C4 PAAF1 Proteasomal ATPase-associated factor 1 1 9639400.0 5836600.0 0.0 3802800.0 True False 7555593.756586244 0.0 3110729.420023054 1.0 0.0 0.4117121063200913 22.849113703406964 -10.72799371115336 6.71017458687099 1.0118765292603542 0.20585605316005193 0.8322367057457037 0.16808076356845347 0.02932168846276885 0.0011885941647292665 0.15978992857660468 0.054247833176537245 1.870709229170199e-11 10.72799371115336 -0.8060204761003023 GHLDALTADVK(ub)EK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GHLDALTADVKEK 13 1 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 19696400.0 6787800.0 7121300.0 5787300.0 True False 8898871.533148708 6058829.798609981 5188485.711701567 1.0 0.6808537212882061 0.5830498499022284 23.085190968689574 -13.999999998441114 0.1656558845079766 2.591987383091264 0.4926611670363906 0.9995226454862128 0.0038897781694894797 12.052202877988059 0.12878930358950205 6.163969547181489 0.08300602806900803 1.0000000035894684e-14 13.999999998441114 -2.0993262160548736 GHLDALTADVK(ub)EK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHLDALTADVKEK 13 1 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 19144200.0 5119200.0 5395500.0 8629500.0 True False 4956693.798108406 7549951.287160793 6369175.070549205 1.0 1.523182910762419 1.284964399652816 22.240946707778356 -10.100412784649649 4.4613530303398905 0.9999640593591029 1.404073655190682 0.7932289393595404 0.09725230000560722 14837103.303881112 16795452.972779278 4608.82961745722 0.033292048535995766 7.935736068354729e-11 10.100412784649649 0.4041095958315791 GHLDALTADVK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHLDALTADVKEK 13 1 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 58476000.0 17081000.0 17015000.0 24380000.0 True False 25913125.78836854 13978540.311198203 19561282.313866373 1.0 0.5394386005517197 0.7548793022355768 24.627179716293917 -10.090052970370703 4.898792085873659 1.0000110805362346 0.6471589513934315 0.7814858025464898 0.08795329816990524 1.1816697554413374e-05 2.194879734170761e-06 0.08516338257379709 0.028386804919727594 8.127313822586028e-11 10.090052970370703 -0.35285212914280306 GHLDALTADVK(ub)EK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GHLDALTADVKEK 13 1 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 23918200.0 5119200.0 9710600.0 9088400.0 True False 4256841.619012399 9658287.070396816 10988742.419986269 1.0 2.26888569855638 2.581430883147514 22.021351983212632 -10.290436054631305 0.3124143679881395 1.4056359314434124e-15 2.6728012952156894 0.9989961090204611 0.021666806745552818 1.7603720894858972 0.1464670115692066 1.5711422079867905 0.10619580888677282 5.123467024616411e-11 10.290436054631305 2.672801295215688 GHLDALTADVK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHLDALTADVKEK 13 1 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 71727000.0 17081000.0 21559000.0 33087000.0 True False 22111691.216847073 20359222.69811591 27065505.50128928 1.0 0.9207447091430102 1.2240359742663127 24.398306038386366 -6.837286242928718 1.2949843223084991 0.9578125430425211 1.2334845988793655 0.9196791748171675 0.036399569559240216 0.17199257495726955 0.5614523416315249 0.02205011740944979 0.05076698597510207 1.454500105457464e-07 6.837286242928718 0.2756720558368444 GHLDNISNNLLIGAINIENGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHLDNISNNLLIGAINIENGK 21 0 Q99798;A2A274 Q99798 ACO2 Aconitate hydratase, mitochondrial 0 12211900.0 4494800.0 3525200.0 4191900.0 False True 4352115.034329126 4932830.743675139 3093915.6356956013 1.0 1.133432987125886 0.7108993239588222 22.05328525947466 -6.821813307575257 1.3641627584171203 1.0717890599824151 0.7013225227644665 0.8884731624411563 0.05889576289693948 0.19113464926594134 0.6984357714180549 0.033923876533178986 0.0781479182600322 1.5072548584168127e-07 6.821813307575257 -0.37046653721794864 GHLDNISNNLLIGAINIENGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHLDNISNNLLIGAINIENGK 21 0 Q99798;A2A274 Q99798 ACO2 Aconitate hydratase, mitochondrial 0 7248280.0 998080.0 1450900.0 4799300.0 False True 1367097.1480978283 1386794.4405153126 3665804.1846861397 1.0 1.0144081146280577 2.6814511242209234 20.38268433611528 -6.908793071516152 0.9039160407692738 0.9463942370702888 2.891416972028279 0.9904580502674689 0.07709814194267599 0.1052215074283151 0.1431370585074791 0.06274700499857397 0.1717950730384258 1.233692511228586e-07 6.908793071516152 1.9450227349579903 up GHLENNPALEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GHLENNPALEK 11 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 34419900.0 2168900.0 17269000.0 14982000.0 False True 2843448.903657476 14692532.514034767 13431806.357491931 1.0 5.1671519383154845 4.723772718481013 21.439210448837706 -10.132855696086963 5.031218427417913 0.9998288781376631 4.945462328406872 0.990617423931538 0.18100880855455934 0.0003474536088797655 5.988574334237052e-05 0.17526791607338435 0.05842034174976746 7.364517591730273e-11 10.132855696086963 3.9456334502692094 GHLENNPALEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHLENNPALEK 11 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 34372100.0 8887000.0 4712100.0 20773000.0 False True 8604887.049497867 6593666.103276884 15331928.123358065 1.0 0.7662699190992465 1.7817698286060304 23.036724824436977 -6.846162741483163 1.2536062700490285 0.8755741717661633 1.819425047347084 0.9345059735317401 0.11112834506637874 0.16173674690266368 0.49107507705054987 0.06943185312450223 0.16031111485420457 1.425073481288935e-07 6.846162741483163 0.9438508755809208 GHLENNPALEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHLENNPALEK 11 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 95377180.0 942880.0 92754000.0 1680300.0 False True 1430417.893761311 76201324.00969018 1348187.9684983462 1.0 53.27207128912332 0.9425133552777786 20.448005258412767 -6.231039084515886 21.868584150628703 9.999999999999998 0.942434991476848 0.0 25.51778565139077 3984.480393082639 4594800.00418436 11.120336456116272 214.32292192568627 5.87436483555627e-07 6.231039084515886 -9.05756500852315 GHLENNPALEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHLENNPALEK 11 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 30420900.0 2168900.0 14423000.0 13829000.0 False True 2970800.9423186285 13785744.169517087 10562875.017195133 1.0 4.640413288262152 3.5555647188367656 21.502420510360597 -9.338212815577835 9.091897327392145 0.9999775250236448 4.097989004248581 0.915777215521651 0.44288757407103 0.0 0.0 0.42882404956854775 0.14294134985618256 4.5897304900551736e-10 9.338212815577835 3.0980114792249362 GHLENNPALEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHLENNPALEK 11 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 5923380.0 942880.0 1731700.0 3248800.0 False True 1220576.7469434333 1635329.3727133574 2657551.7355030244 1.0 1.3398005302071723 2.1772917943571035 20.219131580505216 -6.955766303540631 0.4914848379531312 0.9819163652557771 2.570778739406115 0.9995795215969356 0.010144838837448591 0.0812496622311074 0.02699474193584681 0.01209686539625268 0.06907399642407967 1.1072194251021031e-07 6.955766303540631 1.5888623741503376 up GHLENNPALEK(ub)LLPHIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHLENNPALEKLLPHIR 17 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 1 52815000.0 19727000.0 16912000.0 16176000.0 True False 19100777.18301387 23665049.794914927 11939020.33040196 1.0 1.2389574292275405 0.6250541648650407 24.18712800484266 -6.801150972225205 1.4511825581217075 1.1316551211238244 0.6163358543107285 0.8354931259442879 0.10248004656221148 0.21913239228368855 0.9109434368231389 0.05555131827522001 0.1291038945105335 1.5806984512457401e-07 6.801150972225205 -0.5153192668130959 GHLENNPALEK(ub)LLPHIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GHLENNPALEKLLPHIR 17 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 1 36571200.0 19727000.0 11268000.0 5576200.0 True False 16403874.55427755 11207297.047477128 6742157.6385642635 1.0 0.683210360478809 0.41101007059372735 23.967533280276935 -7.290993476104854 0.20531300817527653 1.173006589208857 3.265127826428825e-12 0.9999770696074198 0.001152516053180283 0.10544313257400258 0.012413685652517504 0.01826973617451692 0.0460947462311965 5.1168952199237016e-08 7.290993476104854 -1.1730065892055919 down GHLENNPALEK(ub)LLPHIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHLENNPALEKLLPHIR 17 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 1 119365400.0 9775400.0 42086000.0 67504000.0 True False 12654448.001941748 39743877.10343267 55218964.64953094 1.0 3.1407041300682743 4.36360121287455 23.59314124141675 -8.619575737016293 0.2595225029255956 1.1979349896349325e-16 5.222806752963871 0.9991793754101886 0.039822138247572095 0.22541370851138937 0.07479126464229832 0.6533714916570731 0.46531003655280084 2.40117748780856e-09 8.619575737016293 5.222806752963871 GHLLYVALSPGQHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GHLLYVALSPGQHR 14 0 O15067 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 161127000.0 44643000.0 58198000.0 58286000.0 False True 58527405.32342702 49515085.25402724 52255123.83879143 1.0 0.846015383398649 0.8928317178939597 25.802608985763637 -10.343131912759572 9.441436723218814 1.000000082051465 0.8694235506463044 0.9120667672923572 0.019112688523494948 3.300628648548404e-08 2.2927655688588622e-09 0.018505792807833186 0.006168593696062134 4.5380375720077105e-11 10.343131912759572 -0.13057653140516057 GHLLYVALSPGQHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHLLYVALSPGQHR 14 0 O15067 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 204474000.0 49702000.0 42702000.0 112070000.0 False True 48124237.21549927 59753131.287988245 82715504.97206652 1.0 1.2416431874112632 1.7187909826324794 25.520260337911367 -6.9602946321952075 0.43126923011167945 0.9813001274593616 1.9974700184937 0.9997809510942499 0.004420093757262423 0.07959615687738017 0.020744379602616336 0.00622960827870271 0.03960646040695531 1.0957345803883772e-07 6.9602946321952075 1.0161698910343384 GHLLYVALSPGQHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHLLYVALSPGQHR 14 0 O15067 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 703950000.0 137800000.0 281160000.0 284990000.0 False True 209052674.52942958 230984801.2868933 228661601.58444548 1.0 1.1049119644454786 1.093798977215455 27.6392912598149 -10.077503385957892 4.141464909344161 0.9999851718022629 1.0993554708521156 0.9907042577108135 0.0045368581409606324 1575505.56645104 0.02463094606947602 225.68215199054742 0.0015530872000080443 8.365590735342376e-11 10.077503385957892 0.09937029904985273 GHLLYVALSPGQHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHLLYVALSPGQHR 14 0 O15067 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 268235000.0 44643000.0 68632000.0 154960000.0 False True 61148723.53171225 65599611.30432622 118361639.50137813 1.0 1.0727879097967712 1.9356354910662164 25.86581904728653 -6.923570096482617 0.7977957688280602 0.983298648837461 2.0868860278367283 0.9951166793314667 0.02969560269974307 0.09611633200280534 0.09505913759621175 0.026082108002299216 0.08100736832123456 1.1924217897307318e-07 6.923570096482617 1.1035873789992672 GHLLYVALSPGQHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GHLLYVALSPGQHR 14 0 O15067 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 126876000.0 49702000.0 31420000.0 45754000.0 False True 41329415.17193196 31250734.223618273 55320949.8574063 1.0 0.7561378280726696 1.3385369627726165 25.300665613345643 -6.792992164810483 1.4846070856219158 0.8642335858048361 1.345229702626934 0.8107971037510721 0.10387555794248178 0.23092186736805306 1.005421435355204 0.05506712474163874 0.12863634692621373 1.610674693405256e-07 6.792992164810483 0.48099611682209786 GHLLYVALSPGQHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHLLYVALSPGQHR 14 0 O15067 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 734670000.0 137800000.0 379780000.0 217090000.0 False True 178384816.44409156 358644909.146549 177581847.53150445 1.0 2.0105125329372053 0.9954986700740937 27.41041758190735 -6.647207152512566 2.018733732493236 1.6571669060333254 0.9997749041152861 0.18277054193400588 0.4315954704984232 0.5153672243766189 4.022553692176995 0.17359199756230465 0.47792830445511925 2.2531642273565738e-07 6.647207152512566 -0.6573920019180393 GHNGWVTQIATTPQFPDMILSASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GHNGWVTQIATTPQFPDMILSASR 24 0 P63244;J3KPE3;D6RAC2;D6REE5;D6RHH4;D6RBD0;D6RFZ9;E9PD14;D6RAU2;D6RGK8;D6R909;D6RHJ5;D6RDI0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 25842400.0 12039000.0 12661000.0 1142400.0 False True 15783245.585841853 10772028.15219145 1024195.4066745949 1.0 0.6824976582670901 0.0648913052200959 23.911890568494112 -7.417549349105035 0.6267943620523578 0.9990028583375642 6.351383379852798e-22 0.9939674697166988 0.030155475587477613 0.11078127401637163 0.09416232599261819 0.027998202171140345 0.06854645740483215 3.8234080560753356e-08 7.417549349105035 -0.9990028583375642 down GHNGWVTQIATTPQFPDMILSASR ddPTM_RPMI8226_Bortezomib_2h_R1 2 GHNGWVTQIATTPQFPDMILSASR 24 0 P63244;J3KPE3;D6RAC2;D6REE5;D6RHH4;D6RBD0;D6RFZ9;E9PD14;D6RAU2;D6RGK8;D6R909;D6RHJ5;D6RDI0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 164878700.0 66157300.0 39402100.0 59319300.0 False True 64057172.724175155 55135564.00923709 43781795.7891453 1.0 0.8607242821447371 0.6834799902528645 25.93285678784981 -6.967845192217859 0.3053066558422238 1.028864437252225 0.5097438029423685 0.9999603549433848 0.0008155455878593433 0.07700833342863021 0.01152004921907723 0.002865890748507562 0.015809169544508537 1.0768489967626218e-07 6.967845192217859 -0.5191206343098566 GHNGWVTQIATTPQFPDMILSASR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GHNGWVTQIATTPQFPDMILSASR 24 0 P63244;J3KPE3;D6RAC2;D6REE5;D6RHH4;D6RBD0;D6RFZ9;E9PD14;D6RAU2;D6RGK8;D6R909;D6RHJ5;D6RDI0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 346989400.0 69039400.0 170884000.0 107066000.0 False True 104737817.2562199 140388415.07721394 85904358.17130524 1.0 1.3403794231627155 0.8201847281307916 26.642207203441803 -6.730155615827797 1.722637781698487 1.2048010446700996 0.8204833213012857 0.5600207111096481 0.14308535762381433 0.3359352746711902 1.9530511014934757 0.06582106382971743 0.16330329138889985 1.8614200355726402e-07 6.730155615827797 -0.384317723368814 GHNGWVTQIATTPQFPDMILSASR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GHNGWVTQIATTPQFPDMILSASR 24 0 P63244;J3KPE3;D6RAC2;D6REE5;D6RHH4;D6RBD0;D6RFZ9;E9PD14;D6RAU2;D6RGK8;D6R909;D6RHJ5;D6RDI0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 54761800.0 15415800.0 11085700.0 28260300.0 False True 21115437.856330648 10595897.118492374 21585799.179148138 1.0 0.5018080700285172 1.0222757077555211 24.331794827837008 -10.983159687433197 12.275554405000864 1.147834684829557 0.7620418888920192 0.2179617538798707 0.21248002334381452 0.07611166858713601 0.00010441428891297336 0.018214525307975127 0.06857763265102976 1.0395378638136176e-11 10.983159687433197 -0.3857927959375379 GHNGWVTQIATTPQFPDMILSASR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GHNGWVTQIATTPQFPDMILSASR 24 0 P63244;J3KPE3;D6RAC2;D6REE5;D6RHH4;D6RBD0;D6RFZ9;E9PD14;D6RAU2;D6RGK8;D6R909;D6RHJ5;D6RDI0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 154959500.0 66157300.0 36300600.0 52501600.0 False True 55012726.215324484 36105041.46269504 63479441.820028886 1.0 0.656303440069064 1.1539046723764417 25.713262063284088 -6.7208936860277335 1.7562496855708596 0.7910980202602329 1.1531604665044648 0.516676672239021 0.14461298315572754 0.35357770981598613 2.131857911901314 0.06537066352190962 0.16392326533545398 1.9015437150878537e-07 6.7208936860277335 0.3620624462442319 GHNGWVTQIATTPQFPDMILSASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHNGWVTQIATTPQFPDMILSASR 24 0 P63244;J3KPE3;D6RAC2;D6REE5;D6RHH4;D6RBD0;D6RFZ9;E9PD14;D6RAU2;D6RGK8;D6R909;D6RHJ5;D6RDI0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 168157000.0 53449000.0 54340000.0 60368000.0 False True 69190784.13730219 51315931.23130094 49381643.427987784 1.0 0.7416584718778386 0.7137026129086043 26.044076555182915 -13.999999999999998 0.3140416921601894 3.5571547057505364 0.7077759431872015 0.9996808411054112 0.0023024177382022157 17.562458076368536 0.17846132404182682 29.411639790838873 0.009529950441421561 1.0000000000000041e-14 13.999999999999998 -2.849378762563335 GHNTNVGAIVFHPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GHNTNVGAIVFHPK 14 0 O43172-2;O43172 O43172-2 PRPF4 U4/U6 small nuclear ribonucleoprotein Prp4 0 20275500.0 4242400.0 6329100.0 9704000.0 False True 5561827.483460034 5384822.950638566 8699923.167340918 1.0 0.9681751127038998 1.564220248329001 22.40712756524634 -6.89429181198725 0.9966384614450684 0.9711891007308486 1.6200143459040284 0.9835057947354624 0.03516222377877334 0.11573170040274776 0.2020573361484757 0.026718622000941536 0.06772663103395056 1.2755814296592903e-07 6.89429181198725 0.6488252451731797 GHNTNVGAIVFHPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHNTNVGAIVFHPK 14 0 O43172-2;O43172 O43172-2 PRPF4 U4/U6 small nuclear ribonucleoprotein Prp4 0 8832870.0 2240400.0 808970.0 5783500.0 False True 2169279.7283329586 1131995.939722818 4268627.848719076 1.0 0.5218303222667972 1.9677627522935541 21.048784669663988 -6.8175971148887875 1.3823545149015877 0.7416253791951147 1.997700041565815 0.8787318753386835 0.20945450743977234 0.196630363831684 0.7389708124367765 0.11909051059067324 0.2746604946116967 1.5219587615679268e-07 6.8175971148887875 1.2560746623707004 GHNTNVGAIVFHPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHNTNVGAIVFHPK 14 0 O43172-2;O43172 O43172-2 PRPF4 U4/U6 small nuclear ribonucleoprotein Prp4 0 15262000.0 4242400.0 4864200.0 6155400.0 False True 5810929.926549192 4649283.56024163 4701621.294442321 1.0 0.8000928627619155 0.809099637041118 22.470337626769233 -9.979923902245817 5.516108572835906 1.000000461405081 0.8045962499026557 0.9984090972474552 0.0036770002030341604 2.086478354131746e-08 3.856674768446619e-09 0.0035602485192331923 0.0011867467123907168 1.0473120436184571e-10 9.979923902245817 -0.19540421150242537 GHNTNVGAIVFHPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GHNTNVGAIVFHPK 14 0 O43172-2;O43172 O43172-2 PRPF4 U4/U6 small nuclear ribonucleoprotein Prp4 0 5732700.0 2240400.0 2283800.0 1208500.0 False True 1862991.8665485594 2271496.7161011943 1461191.7625273322 1.0 1.219273555020637 0.7843253579170931 20.829189945098264 -6.769637545862717 1.5757499174829168 1.1258281450862244 0.7819073348715974 0.729197006887451 0.09240460073776119 0.267020312195968 1.308400027851608 0.04622343911939643 0.11007167970581146 1.6996615667856012e-07 6.769637545862717 -0.34392081021462706 GHQFSCVCLHGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GHQFSCVCLHGDR 13 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 20582210.0 6777440.0 4973340.0 8831430.0 False True 8885289.47282232 4231337.05792748 7917638.340658443 1.0 0.47621825612659974 0.891095148320867 23.082987347739337 -9.915615333249793 6.715040022371257 1.0000000165375895 0.683656702223731 0.4366853175664639 0.1693727819912877 4.189658860262982e-08 6.914398506912759e-09 0.1639944983193756 0.05466483032942046 1.2144640589542706e-10 9.915615333249793 -0.31634331431385854 GHQFSCVCLHGDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHQFSCVCLHGDR 13 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 16351600.0 3569200.0 9995500.0 2786900.0 False True 5414737.343471989 8211724.929802043 2236067.9934583353 1.0 1.5165509255406644 0.4129596417366653 22.368459927017266 -6.779419662583539 1.5380752609550319 1.292702739697489 0.40436693754794595 0.7653542961528321 0.21839064961537047 0.25147472005707866 1.1750113612739324 0.11183739436627498 0.26402382864825824 1.6618060564311587e-07 6.779419662583539 -0.8883358021495431 down GHQFSCVCLHGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHQFSCVCLHGDR 13 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 15399240.0 6777440.0 3338300.0 5283500.0 False True 9283242.721429283 3190802.867718155 4035646.117098164 1.0 0.34371641068401226 0.4347237531323344 23.14619740926223 -10.741954740298636 6.985206557819549 1.0096246580612835 0.38922008190817337 0.9836215546035083 0.03715359197418687 0.00552413984198516 0.00020407079760068278 0.03568485025467488 0.01199127024731762 1.8115288700206665e-11 10.741954740298636 -0.6204045761531102 GHQFSCVCLHGDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHQFSCVCLHGDR 13 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 10586600.0 3569200.0 4738200.0 2279200.0 False True 4620399.7594503015 4474515.004787452 1864408.9865668823 1.0 0.9684259453168602 0.4035168131834322 22.139586249109716 -6.918417474021635 0.8363830223694225 1.0131896146258403 0.3156564252108591 0.9937298037207539 0.021700222994643727 0.09911205490832616 0.11050643957262056 0.018541908723808096 0.054728459761492924 1.2066533584097836e-07 6.918417474021635 -0.6975331894149812 down GHQQLYWSHPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GHQQLYWSHPR 11 0 A0A2R8Y851;P62273;P62273-2 A0A2R8Y851 RPS29 40S ribosomal protein S29 0 115554000.0 19630000.0 27547000.0 68377000.0 False True 25735120.097190432 23437094.977364995 61302003.95849854 1.0 0.9107047058204202 2.3820368324292773 24.617235179346494 -6.892464684181771 1.0076630661903931 0.9255513888095306 2.5148815220797673 0.9824303792366939 0.08927707061185591 0.11716715628026912 0.21033667829965783 0.06727793384580887 0.16928807034565466 1.2809592549316117e-07 6.892464684181771 1.5893301332702368 up GHQQLYWSHPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHQQLYWSHPR 11 0 A0A2R8Y851;P62273;P62273-2 A0A2R8Y851 RPS29 40S ribosomal protein S29 0 114768900.0 20920000.0 9960900.0 83888000.0 False True 20255906.051029045 13938339.315407274 61915216.21394419 1.0 0.6881123599355939 3.056650048532327 24.271839282738295 -6.873745262358843 1.1140480852514831 0.8188921893877625 3.205633555313432 0.9682824172845073 0.18713611659725984 0.13331678857142054 0.30697199453337914 0.13004152831535606 0.31005519576960494 1.3373797334275515e-07 6.873745262358843 2.386741365925669 up GHQQLYWSHPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHQQLYWSHPR 11 0 A0A2R8Y851;P62273;P62273-2 A0A2R8Y851 RPS29 40S ribosomal protein S29 0 74453000.0 21789000.0 38312000.0 14352000.0 False True 33055505.98927243 31474924.266977753 11515320.909294946 1.0 0.952184010651429 0.34836317172189213 24.978387262777133 -6.922671602019338 0.8046689337044807 1.0120842337370284 0.24474733478031432 0.994891296241562 0.021196496500082186 0.0966253902837713 0.09765654852574802 0.018526191322624563 0.056994553424512304 1.1948912970753015e-07 6.922671602019338 -0.7673368989567141 down GHQQLYWSHPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHQQLYWSHPR 11 0 A0A2R8Y851;P62273;P62273-2 A0A2R8Y851 RPS29 40S ribosomal protein S29 0 77391000.0 19630000.0 26040000.0 31721000.0 False True 26887741.48080352 24889466.697235294 24229153.11450189 1.0 0.9256808242895785 0.9011226596254012 24.680445240869386 -13.9999999989321 0.15476238240272686 1.3622550701067377 0.8755291579748824 0.9995511116531776 0.000890595844209734 11.978747651691846 0.12412076036285417 1.3034599981872572 0.0231823273885695 1.0000000024589296e-14 13.9999999989321 -0.48672591213185534 GHQQLYWSHPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GHQQLYWSHPR 11 0 A0A2R8Y851;P62273;P62273-2 A0A2R8Y851 RPS29 40S ribosomal protein S29 0 58954000.0 20920000.0 22979000.0 15055000.0 False True 17395906.913138654 22855207.56602563 18202930.89354485 1.0 1.3138267340786765 1.0463916014517571 24.05224455817257 -10.328286207137817 8.201826934928711 0.9999994424863059 1.1801091677652167 0.3768486672601724 0.1091799357049163 1.1130812336825955e-06 9.113325458896127e-08 0.10571334424662022 0.035237672727094785 4.69584542749193e-11 10.328286207137817 0.18010972527891078 GHQQLYWSHPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHQQLYWSHPR 11 0 A0A2R8Y851;P62273;P62273-2 A0A2R8Y851 RPS29 40S ribosomal protein S29 0 120053000.0 21789000.0 32773000.0 65491000.0 False True 28206290.025401384 30949153.740217622 53572309.99440675 1.0 1.097242980638224 1.8993036640466296 24.749513584869582 -6.92953152410139 0.7506237188675715 0.9875893665710707 2.0620175534756915 0.9964455118167467 0.02402521960381254 0.09288142144374906 0.07887585319097253 0.021827605310152643 0.0727602494546573 1.1761656073402997e-07 6.92953152410139 1.0744281869046208 GHSEK(ub)EVADAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHSEKEVADAIR 12 1 A0A5F9UP49;Q9BRK5;A0A5F9UJX7;Q9BRK5-6;H0Y3T6;G3V1E2;Q9BRK5-4;Q9BRK5-3;Q9BRK5-2 A0A5F9UP49 SDF4 45 kDa calcium-binding protein 1 11653900.0 1369200.0 2698000.0 7586700.0 True False 2077176.501928119 2216520.8204297866 6087185.419631269 1.0 1.0670835234137892 2.930509474751374 20.98619237945836 -6.914525125309983 0.8643405250137302 0.9502293938085612 3.196184298794448 0.9925203317545369 0.07737460118241025 0.10150140203159985 0.12309487113647288 0.0648005880787263 0.18501987357096655 1.2175165536225877e-07 6.914525125309983 2.245954904985887 up GHTAMLHTGSWHPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHTAMLHTGSWHPK 14 0 Q9NW82;D6RIW8 Q9NW82 WDR70 WD repeat-containing protein 70 0 3666840.0 1530600.0 545940.0 1590300.0 False True 2096504.1829097231 521818.56561784405 1214703.893256594 1.0 0.2488993677530449 0.5793949295015072 20.999554277952118 -10.562181414841787 6.4064216384551536 1.0009182016953857 0.41414714863143715 0.8073112225485473 0.1349242480897038 0.0017719259617439806 0.0001210943564645846 0.13082049768234852 0.04354661382091504 2.7404291921964385e-11 10.562181414841787 -0.5867710530639485 GHTAMLHTGSWHPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GHTAMLHTGSWHPK 14 0 Q9NW82;D6RIW8 Q9NW82 WDR70 WD repeat-containing protein 70 0 3171800.0 861120.0 1644100.0 666580.0 False True 716059.434084224 1635242.9069716993 805958.7960823074 1.0 2.2836692446668603 1.125547346657134 19.44971981290396 -6.621616484143209 2.111381288497045 1.8508270674077523 1.1300657168318524 0.08799462402379221 0.5518058850611604 0.5811487796336258 4.925429166645093 0.21460819320397687 0.6115466945349354 2.3899208375874716e-07 6.621616484143209 -0.7207613505758999 GHVDILAPTVQELAALEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHVDILAPTVQELAALEK 18 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 9466300.0 2969300.0 2170700.0 4326300.0 False True 2875041.1968126493 3037471.83005096 3193112.243782027 1.0 1.05649680200005 1.1106318223620588 21.455151198080834 -6.971645078557022 0.21530076042230067 0.9735054613247055 1.1951435161272324 0.9999925116849032 0.00012346822093891642 0.07577242369863613 0.0070881104225051185 0.0015549077254770358 0.005542899077781721 1.0674681391306702e-07 6.971645078557022 0.22163805480252685 GHVDILAPTVQELAALEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHVDILAPTVQELAALEK 18 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 4581300.0 0.0 1812800.0 2768500.0 False True 0.0 1732704.50187205 2114637.3190472736 0.0 GHVDILAPTVQELAALEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GHVDILAPTVQELAALEK 18 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 2969300.0 2969300.0 0.0 0.0 False True 2469104.512293627 0.0 0.0 1.0 0.0 0.0 21.23555647351511 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 GHVEIPNLSDENSVDEVEISVSLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHVEIPNLSDENSVDEVEISVSLAK 25 0 O95433;O95433-2;H0YJU2;H0YJG7 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 0 36981400.0 4805400.0 19103000.0 13073000.0 False True 7290143.12179768 15693920.39757974 10489115.81990055 1.0 2.152758887634811 1.4388079417176152 22.79751570748145 -10.110344976530996 4.742354070473164 0.9999621445610122 1.795783414685144 0.6235650118742349 0.2914692532371249 203095598.11825353 10.490847694725016 106571.09069488192 0.09977767799642498 7.756307590185578e-11 10.110344976530996 0.7958212701241317 GHVFEESQVAGTPMFVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GHVFEESQVAGTPMFVVK 18 0 P13639 P13639 EEF2 Elongation factor 2 0 14938800.0 2006600.0 6306400.0 6625800.0 False True 2630672.031942044 5365509.702154669 5940225.775161518 1.0 2.039596588630504 2.258063986325296 21.326999967054867 -10.628537678382505 0.31732587342143576 1.5089583830557185e-23 2.315171275110736 0.9991433416407774 0.016064397807883702 2.2379558586163686 0.15511032995240887 1.8244082282949245 0.07305959441765189 2.352135418720144e-11 10.628537678382505 2.315171275110736 GHVFEESQVAGTPMFVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHVFEESQVAGTPMFVVK 18 0 P13639 P13639 EEF2 Elongation factor 2 0 14766800.0 2006600.0 4878600.0 7881600.0 False True 2748494.2463260493 4663047.320627197 6020128.406647278 1.0 1.696582529456031 2.1903369143648264 21.39021002857776 -7.647534861517258 0.12200191958218874 1.2268960063601013e-19 3.5660011285321462 0.9999900713694145 0.0015386058838064527 0.13953608049028624 0.013697525147535751 0.15572346483162908 0.2218267640310009 2.2514646807960432e-08 7.647534861517258 3.5660011285321462 GHVLSLALQMYGCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHVLSLALQMYGCR 14 0 H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;H0YDK8;H0YC97;H0YDC5 H0YEH2 PUM1 Pumilio homolog 1 0 39469200.0 4172200.0 22280000.0 13017000.0 False True 6329532.428676972 18303959.92556545 10444184.244446235 1.0 2.8918344493562267 1.6500720017053971 22.59366749903406 -10.132837739400735 4.8156229922219085 0.9999296631348622 2.270953225525759 0.5827695343135111 0.5069473965118844 0.0004613637994849964 8.307867459595124e-05 0.49088199178541764 0.1636165686602212 7.364822097246843e-11 10.132837739400735 1.2710235623908968 GHYAYDCHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GHYAYDCHR 9 0 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629;F8WEA1 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 7427850.0 754150.0 4211700.0 2462000.0 False True 988697.9531989893 3583330.7770780134 2207255.857171613 1.0 3.6242927028259135 2.2324875357837133 19.9151703200141 -9.85016277612945 6.124793026243971 0.9999998252531759 2.9283901193058415 0.7190693450038921 0.5682020801074161 1.3566032285513968e-06 2.556528249093919e-07 0.5501593475671097 0.18338643279416483 1.4120082164362188e-10 9.85016277612945 1.9283902940526656 GHYAYDCHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHYAYDCHR 9 0 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629;F8WEA1 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 1939570.0 935610.0 415110.0 588850.0 False True 905909.5726770213 580865.5877700527 434612.51987866015 1.0 0.6411959927231561 0.47975265190581007 19.78900752298495 -13.999999999999995 0.10785132250444962 2.7382202734449264 0.17421478651509292 0.9997539844679135 0.003410276216868054 12.025693400213111 0.09929689546931969 4.570648049621364 0.27154646665151194 1.0000000000000123e-14 13.999999999999995 -2.564005486929833 GHYAYDCHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHYAYDCHR 9 0 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629;F8WEA1 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 6510350.0 754150.0 3139900.0 2616300.0 False True 1032979.6351374411 3001168.8357392144 1998383.82438988 1.0 2.905351406409769 1.934582015379218 19.97838038153699 -10.446626806970029 7.316668456152293 0.9998731092462572 2.4199667108944936 0.7404447825919245 0.39631494432286785 0.0008203945537235381 6.204682063515267e-05 0.3837628194853117 0.12791009826796562 3.5757997775771856e-11 10.446626806970029 1.4200936016482364 GHYNNVSCAVFHPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GHYNNVSCAVFHPR 14 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 14934800.0 4966400.0 4378100.0 5590300.0 False True 6510998.4946860215 3724904.5457001347 5011869.381944135 1.0 0.572094210855713 0.7697543450569975 22.634447374292726 -10.067868433171977 4.80778082047644 1.0000098442849277 0.670924277952733 0.7870374841131703 0.08069441189802035 111983174.90791385 4.241280863417679 13462.427253816997 0.02762384353556812 8.553257892992385e-11 10.067868433171977 -0.32908556633219466 GHYNNVSCAVFHPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHYNNVSCAVFHPR 14 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 12253400.0 2103900.0 7896300.0 2253200.0 False True 3191770.115692793 6487143.570926505 1807854.0323873577 1.0 2.0324595242719825 0.5664111031990636 21.605925315842704 -6.717465918625842 1.768370118567609 1.629843634402757 0.5690148454106827 0.5004976062426915 0.4346060154867092 0.36029683745126045 2.2005177918168375 0.19524387122734738 0.4916138118103935 1.9166114634246835e-07 6.717465918625842 -1.0608287889920742 GHYNNVSCAVFHPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHYNNVSCAVFHPR 14 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 12059900.0 4966400.0 2893800.0 4199700.0 False True 6802612.291913533 2765942.347483083 3207817.355536507 1.0 0.40660002787032873 0.4715566929118884 22.697657435815618 -10.211783768701853 5.429136959203116 1.0000294827725227 0.43907836039391046 0.9900423216577311 0.026518447457675298 9.463937513534513e-06 1.374016322592471e-06 0.02567772265650222 0.008558792114205191 6.1406766780808e-11 10.211783768701853 -0.5609511223786122 GHYNNVSCAVFHPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHYNNVSCAVFHPR 14 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 10635100.0 2103900.0 3257500.0 5273700.0 False True 2723540.0240691165 3076217.2614273666 4313940.7127315635 1.0 1.1294922175703264 1.5839461416418996 21.377051637935153 -6.947882758522179 0.5816332159093434 0.9946003107182259 1.7413788284495535 0.999024408524396 0.007821025232887678 0.0843474201664879 0.03956952021610649 0.008179989051251346 0.03798010476119296 1.127501793763845e-07 6.947882758522179 0.7467785177313276 GHYTEGAELVDSVLDVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHYTEGAELVDSVLDVVR 18 0 A0A0B4J269;Q13509;Q13509-2;G3V2A3;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 A0A0B4J269;P07437;P68371;Q13885;Q9BVA1 TUBB3;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-3 chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 117005300.0 37798000.0 14453000.0 64754300.0 False True 36598123.179579124 20224158.271399334 47793206.242640205 1.0 0.5526009673273062 1.3058922723476616 25.125266330509376 -6.745821780469602 1.6654110068753711 0.7356045788822237 1.3069146152987992 0.6307310343018608 0.18797412313161924 0.30740255326064514 1.676161164353254 0.08921519401833954 0.21754033695486066 1.7954702749723198e-07 6.745821780469602 0.5713100364165754 GHYTEGAELVDSVLDVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHYTEGAELVDSVLDVVR 18 0 A0A0B4J269;Q13509;Q13509-2;G3V2A3;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 A0A0B4J269;P07437;P68371;Q13885;Q9BVA1 TUBB3;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-3 chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 356943400.0 9670400.0 334887000.0 12386000.0 False True 14670703.800939022 275123798.36592674 9937901.67102334 1.0 18.75327878600596 0.6773977449116824 23.806434747613352 -6.507898744576134 2.5769751323589296 9.999999999999998 0.6605226351050989 0.26254732572204575 7.253043052460604 0.5796953171015587 7.194421932969586 2.8028115333556776 9.379095656251822 3.105283498190766e-07 6.507898744576134 -9.339477364894899 GHYTEGAELVDSVLDVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHYTEGAELVDSVLDVVR 18 0 A0A0B4J269;Q13509;Q13509-2;G3V2A3;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 A0A0B4J269;P07437;P68371;Q13885;Q9BVA1 TUBB3;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-3 chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 23073900.0 9250600.0 8124700.0 5698600.0 False True 12670796.808065264 7765723.889209977 4352708.046351013 1.0 0.6128836257769448 0.3435228354053007 23.595003915990855 -8.106085946949225 0.19932197534475465 1.2644602759024033 1.0199028361412744e-16 0.9998166455733117 0.003648427213128658 0.09123154352951604 0.0381993571619583 0.09171247099889404 0.10930468949395167 7.832746172516613e-09 8.106085946949225 -1.2644602759024033 down GHYTEGAELVDSVLDVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GHYTEGAELVDSVLDVVR 18 0 A0A0B4J269;Q13509;Q13509-2;G3V2A3;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 A0A0B4J269;P07437;P68371;Q13885;Q9BVA1 TUBB3;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-3 chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 61908000.0 37798000.0 12229000.0 11881000.0 False True 31430711.735316172 12163119.949733539 14365262.168462733 1.0 0.3869820083032614 0.4570453984445296 24.905671605943652 -10.377897391606728 5.870475278006598 1.000128789233656 0.42201370337590743 0.9890994489708046 0.02860325924927801 4.822424904361334e-05 5.110383868517268e-06 0.02770107294394605 0.009231662226641874 4.188925228836023e-11 10.377897391606728 -0.5781150858577484 GHYTEGAELVDSVLDVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHYTEGAELVDSVLDVVR 18 0 A0A0B4J269;Q13509;Q13509-2;G3V2A3;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 A0A0B4J269;P07437;P68371;Q13885;Q9BVA1 TUBB3;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-3 chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 28653700.0 9670400.0 10418000.0 8565300.0 False True 12518523.432082323 9838229.141841989 7006503.287399667 1.0 0.7858937354088177 0.5596908713246072 23.5775610697058 -6.970429797107934 0.24770652883811178 1.073842229723537 0.2651364449487143 0.9999855422745721 0.0006835514120865234 0.07616353183811457 0.008529714907312753 0.005124599500874698 0.021761603340193874 1.0704594066908065e-07 6.970429797107934 -0.8087057847748227 GHYTIGK(ub)EIIDLVLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GHYTIGKEIIDLVLDR 16 1 F8VVB9;F8VS66;F8VRZ4;P68363;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 8070000.0 4361500.0 1763700.0 1944800.0 True False 4223046.5698644025 2467954.6075739935 1435398.5372506033 1.0 0.5844014662744382 0.3398964499926631 22.00985272594527 -8.966215706984618 0.17028423879950136 1.4499435884343248 2.495629345654097e-11 0.9997643079555536 0.004183285724060472 0.44280801753932614 0.054396744801894104 0.2602863147406141 0.1553164972037891 1.0808969540654262e-09 8.966215706984618 -1.4499435884093685 GHYTIGK(ub)EIIDLVLDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GHYTIGKEIIDLVLDR 16 1 F8VVB9;F8VS66;F8VRZ4;P68363;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 53793000.0 10450000.0 10954000.0 32389000.0 True False 15853413.997333363 8999173.116007367 25987299.953396965 1.0 0.5676489062558437 1.6392242048159584 23.91829021919149 -6.797163382796293 1.4672964285597585 0.7605920053299935 1.6530319931541857 0.8238083736936244 0.18476546267426378 0.2248179469296599 0.9558231765458904 0.09907385487491967 0.23083612123589364 1.5952788859641944e-07 6.797163382796293 0.8924399878241922 GHYTIGK(ub)EIIDLVLDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GHYTIGKEIIDLVLDR 16 1 F8VVB9;F8VS66;F8VRZ4;P68363;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 32812000.0 10450000.0 10010000.0 12352000.0 True False 13527731.000295756 9452934.700502817 10104062.742222782 1.0 0.6987819834897772 0.7469148183092846 23.68941654128394 -10.290094583420645 5.593475589392913 1.000029640038969 0.7228484008995527 0.9778795096126396 0.019650147530260967 7.263968603110832e-06 9.219257711647026e-07 0.01902820565171878 0.0063420578445990685 5.1274970193182146e-11 10.290094583420645 -0.2771812391394163 GHYTIGK(ub)EIIDPVLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GHYTIGKEIIDPVLDR 16 1 P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8 P68366-2 TUBA4A Tubulin alpha-4A chain 1 17725100.0 4647100.0 6949800.0 6128200.0 True False 6092393.10258041 5912916.930108228 5494112.649845276 1.0 0.9705409402429784 0.9017987771534745 22.538577601898954 -6.9569217604307605 0.47684687575110807 1.001699975251087 0.8677889573045756 0.9996384037548344 0.00078239449181065 0.08081971499734301 0.025338264811577433 0.0009631311284863344 0.005671371042131161 1.1042775411887848e-07 6.9569217604307605 -0.13391101794651128 GHYTIGK(ub)EIIDPVLDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GHYTIGKEIIDPVLDR 16 1 P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8 P68366-2 TUBA4A Tubulin alpha-4A chain 1 17946600.0 4647100.0 5853600.0 7445900.0 True False 6365258.453155467 5594968.596733363 5687331.7731241025 1.0 0.8789852977548388 0.8934958124606402 22.601787663421845 -10.107191206747645 4.893239413551325 1.000004866986675 0.8862405551070826 0.9879445081270405 0.005923892824663727 3.1454781227135793e-07 5.739249515713251e-08 0.005736029938692197 0.0019119281875630979 7.812837532090829e-11 10.107191206747645 -0.11376431187959246 GIAFPTSISVNNCVCHFSPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIAFPTSISVNNCVCHFSPLK 21 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 277434400.0 72846900.0 146993200.0 57594300.0 False True 95502991.35038315 125062387.53500593 51634994.319536574 1.0 1.3095127782560727 0.5406636335619808 26.509042586247627 -6.797442786575233 1.4663992867548017 1.1713283100273482 0.530715427950076 0.8245679900892167 0.1322973902287109 0.22442439056803828 0.9529977668050591 0.07098546192557213 0.16534481892308242 1.5942528918079765e-07 6.797442786575233 -0.6406128820772722 GIAFPTSISVNNCVCHFSPLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIAFPTSISVNNCVCHFSPLK 21 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 268849600.0 181422000.0 57914600.0 29513000.0 False True 175662857.91538185 81040201.80064914 21782659.92897835 1.0 0.4613394246362929 0.12400265023281828 27.388233939825657 -8.387293291025541 0.3451602687434579 1.124075127416918 5.754198926980923e-19 0.9981229193003955 0.01562998144756549 0.13627081134375266 0.09319325859563203 0.09328124361767663 0.08867496109721958 4.099271743767608e-09 8.387293291025541 -1.124075127416918 GIAFPTSISVNNCVCHFSPLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIAFPTSISVNNCVCHFSPLK 21 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 541325600.0 173419600.0 202868000.0 165038000.0 False True 263090211.87100065 166664620.3850815 132418166.9612748 1.0 0.6334884874652847 0.5033184853954299 27.970982333912655 -13.999999999999998 0.1442016028030778 2.758342963383669 0.3500986124197178 0.9995867270141944 0.004274847553604842 11.9406348564107 0.11926465007743522 5.895479457882566 0.13739977095476028 1.0000000000000041e-14 13.999999999999998 -2.4082443509639515 GIAFPTSISVNNCVCHFSPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIAFPTSISVNNCVCHFSPLK 21 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 409611700.0 72846900.0 85494800.0 251270000.0 False True 99780367.54345112 81717357.04250364 191925201.06809017 1.0 0.8189722994046738 1.9234765895657076 26.57225264777052 -6.864846236778967 1.1610777901212388 0.9002121398604643 1.9821120184643786 0.9592595616982167 0.09762706276784248 0.1418884714620701 0.36076886240968103 0.06544174629390967 0.1536864362637124 1.3650663567442462e-07 6.864846236778967 1.0818998786039142 GIAFPTSISVNNCVCHFSPLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIAFPTSISVNNCVCHFSPLK 21 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 352340300.0 181422000.0 16160000.0 154758300.0 False True 150860431.35733452 16072942.872491127 187117545.0084679 1.0 0.10654180640926354 1.2403354764726426 27.168639215259933 -6.696654330564618 1.843403174529652 0.44337431391349363 1.2366939923155866 0.40149015387624354 0.3773767456026465 0.40249766769336204 2.656824958844568 0.16348937770779262 0.4221025220018121 2.010692553017871e-07 6.696654330564618 0.793319678402093 GIAFPTSISVNNCVCHFSPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIAFPTSISVNNCVCHFSPLK 21 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 497463100.0 173419600.0 204631000.0 119412500.0 False True 224495090.81137738 193243104.96489406 97680650.27571857 1.0 0.8607898919591899 0.4351126339675314 27.742108656005104 -6.95102065528623 0.5475221961832912 1.0059753118611567 0.2700142590987413 0.9992789755572782 0.006452393786417764 0.0830784419057476 0.034285867075366835 0.0070257844505278114 0.03529734872747812 1.1193846436471277e-07 6.95102065528623 -0.7359610527624154 down GIAFPTSISVNNCVCHFSPLK(ub)SDQDYILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIAFPTSISVNNCVCHFSPLKSDQDYILK 29 1 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 38008500.0 11056000.0 9575500.0 17377000.0 True False 16772760.301867705 7866677.211277016 13942428.333390348 1.0 0.46901506190373654 0.8312542528755872 23.99961679772414 -10.117623983507118 5.632723014944488 1.0000037473238552 0.6501346573896202 0.5543270026247488 0.14788353045343944 6.95937555391676e-06 1.0902027130699104e-06 0.1431891464238856 0.04772920421868618 7.62739111351077e-11 10.117623983507118 -0.34986908993423504 GIAFPTSISVNNCVCHFSPLK(ub)SDQDYILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIAFPTSISVNNCVCHFSPLKSDQDYILK 29 1 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 37520300.0 11056000.0 9431300.0 17033000.0 True False 14312209.946341606 8906439.864220994 13933168.773338772 1.0 0.6222966192930673 0.9735162372251448 23.77074311981659 -10.487067033849108 8.783743061764586 1.0000063107520054 0.7979064291966051 0.3062564094250707 0.14338480859814176 1.7720631354130356e-05 1.0348252478726655e-06 0.1388360768703272 0.04627724798331177 3.25786411616419e-11 10.487067033849108 -0.20209988155540026 GIALIFNHER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIALIFNHER 10 0 P55212;D6RHU3;D6RBM3 P55212 CASP6 Caspase-6;Caspase-6 subunit p18;Caspase-6 subunit p11 0 5159000.0 1618200.0 1898400.0 1642400.0 False True 2121475.8706710925 1615166.11990524 1472460.2030132632 1.0 0.7613407921506596 0.6940735095645824 21.016636839062357 -13.999999999031425 0.1776367857991151 2.2295094948803142 0.6393154068089844 0.9995011775991528 0.0029317068628760424 12.175066689933265 0.13358495847364446 5.164016018087802 0.05125135142639633 1.0000000022302253e-14 13.999999999031425 -1.59019408807133 GIALIFNHER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIALIFNHER 10 0 P55212;D6RHU3;D6RBM3 P55212 CASP6 Caspase-6;Caspase-6 subunit p18;Caspase-6 subunit p11 0 5119600.0 1618200.0 1881300.0 1620100.0 False True 2216492.2702107104 1798177.9453728404 1237465.747006859 1.0 0.8112719225508046 0.558299148450998 21.07984690058525 -6.967059371977896 0.32075266169704714 1.0343400053364546 0.3270625786014984 0.9999495146081525 0.0012857513615280884 0.07726895800828423 0.012431901098173204 0.0038229458138287365 0.02223728917703746 1.0787992305506189e-07 6.967059371977896 -0.7072774267349562 GIALIFNHER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIALIFNHER 10 0 P55212;D6RHU3;D6RBM3 P55212 CASP6 Caspase-6;Caspase-6 subunit p18;Caspase-6 subunit p11 0 6529400.0 2525800.0 4003600.0 0.0 False True 3269697.890961443 3780796.140552755 0.0 1.0 1.156313600410656 0.0 21.640725911057714 -6.933409886228689 1.23388182481239 1.0840633550655656 1.744212055861454e-21 0.9655771302624762 0.09503767520681514 0.11522246703434445 0.3500883374315417 0.06366211001581788 0.12275334070524177 1.1657089040783587e-07 6.933409886228689 -1.0840633550655656 down GIALQLCK(ub)AGATVYITGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIALQLCKAGATVYITGR 18 1 Q96LJ7;H0YNC2 Q96LJ7 DHRS1 Dehydrogenase/reductase SDR family member 1 1 134191000.0 41743000.0 49238000.0 43210000.0 True False 63327182.82207534 40451094.20175007 34669524.56038418 1.0 0.6387635198521597 0.5474667120088385 25.916321565202747 -13.999999999999998 0.19313963501497722 2.957912894935552 0.4839989850362753 0.9994879862064332 0.004421342661502016 12.403589575246722 0.13936826812110717 9.149501972866956 0.06125373273124795 1.0000000000000041e-14 13.999999999999998 -2.473913909899277 GIALQLCK(ub)AGATVYITGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIALQLCKAGATVYITGR 18 1 Q96LJ7;H0YNC2 Q96LJ7 DHRS1 Dehydrogenase/reductase SDR family member 1 1 104950100.0 41743000.0 52609100.0 10598000.0 True False 54037136.37754512 49681357.33788432 8669272.74466296 1.0 0.9193928595840467 0.16043175722882005 25.687447887295196 -6.927198988011471 0.7694479161909706 1.0128201099099872 0.015187377729339466 0.9959582194317784 0.024044784529379786 0.09411902103102522 0.08500187034713629 0.02155125059172206 0.06976077664978757 1.1824996258283453e-07 6.927198988011471 -0.9976327321806477 down GIASAK(ub)TYYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIASAKTYYR 10 1 A0A5F9ZI68;E7EN32;A0A5F9ZHS3;O00255-3;O00255-2;O00255 A0A5F9ZI68 MEN1 Menin 1 3537280.0 487700.0 1192900.0 1856680.0 True False 405544.1587733139 1186473.61092789 2244903.203681628 1.0 2.925633584556424 5.535533320149376 18.629499489186774 -6.966887633271322 0.32402499099782006 0.6590434568843752 7.886806002625109 0.99994693460439 0.013539408318559654 0.07732611604352231 0.01263177214784101 0.03893623579931333 0.2287716064410412 1.07922591849908e-07 6.966887633271322 7.227762545740734 GIAYIEFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIAYIEFK 8 0 P19338;H7BY16 P19338 NCL Nucleolin 0 292250000.0 84618000.0 91982000.0 115650000.0 False True 110935017.44187774 78258644.14302781 103683647.3931345 1.0 0.7054458181703529 0.9346340748308581 26.72513959362901 -9.846489910760628 5.684871360287743 1.0000000498447432 0.8200399472335673 0.4511722056232321 0.09356571397838341 5.909062219488301e-08 1.1992051028166718e-08 0.0905946386518498 0.03019820433418326 1.424000327686617e-10 9.846489910760628 -0.1799601026111759 GIAYIEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIAYIEFK 8 0 P19338;H7BY16 P19338 NCL Nucleolin 0 251766000.0 88314000.0 40642000.0 122810000.0 False True 85510520.41063964 56870562.54523014 90642376.77897295 1.0 0.6650709441613225 1.0600143274030966 26.349598590766284 -6.681946752822182 1.8945807663997076 0.7884654584191781 1.0585497843835776 0.3332565803675842 0.14188956458713875 0.4341972582205268 3.0148001397199167 0.06005224418196615 0.158012447225549 2.0799516863559916e-07 6.681946752822182 0.27008432596439946 GIAYIEFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIAYIEFK 8 0 P19338;H7BY16 P19338 NCL Nucleolin 0 394561000.0 88431000.0 177160000.0 128970000.0 False True 134156292.17207526 145544413.84260234 103479022.9704409 1.0 1.0848869738880391 0.7713318644623375 26.999339480283737 -6.834615310474918 1.307242226584693 1.0452332022006077 0.7620755051035761 0.9147773472691342 0.0386567993698203 0.17518609023631446 0.5838534304672139 0.023206685250756264 0.05340879566126027 1.4634729160758185e-07 6.834615310474918 -0.28315769709703154 GIAYIEFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIAYIEFK 8 0 P19338;H7BY16 P19338 NCL Nucleolin 0 270048000.0 84618000.0 83860000.0 101570000.0 False True 115903561.31546777 80154787.91206422 77581257.89981262 1.0 0.6915644955369223 0.6693604322359947 26.7883496551519 -13.999999999999998 0.3734869542917824 5.391608573840779 0.667183211239987 0.9997968081542813 0.0021510582252144464 23.233237189328975 0.19868806070149367 81.81257341422086 0.0061387959689488516 1.0000000000000041e-14 13.999999999999998 -4.724425362600792 GIAYIEFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIAYIEFK 8 0 P19338;H7BY16 P19338 NCL Nucleolin 0 167119000.0 88314000.0 41172000.0 37633000.0 False True 73437003.97356257 40950198.263997875 45501886.30466785 1.0 0.5576234874551801 0.6196043389930314 26.13000386620056 -10.428423865860882 5.98700037431564 1.0001556765041493 0.5886139132242023 0.983260375876967 0.025303576681822773 5.259911333623767e-05 5.021592955884212e-06 0.024509240493019932 0.008166694257348416 3.728860481266684e-11 10.428423865860882 -0.41154176327994696 GIAYIEFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIAYIEFK 8 0 P19338;H7BY16 P19338 NCL Nucleolin 0 359301000.0 88431000.0 166090000.0 104780000.0 False True 114475672.73561281 156846945.49515608 85711115.1335899 1.0 1.3701334243949088 0.7487277697117704 26.770465802376187 -6.745356234922061 1.6669408539061261 1.21885295992932 0.7479116331788546 0.6287591201766314 0.15551050331134023 0.3082302516070334 1.6835721742125176 0.07374175987567588 0.1799129362037908 1.7973959760756227e-07 6.745356234922061 -0.4709413267504655 GICIALGMSKPPANITMFQFFSGIEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GICIALGMSKPPANITMFQFFSGIEK 26 1 Q8NCA5;E9PH82 Q8NCA5 FAM98A Protein FAM98A 0 33215900.0 15709000.0 8637200.0 8869700.0 False True 20335610.17068385 8156532.227291008 7255505.610807428 1.0 0.4010960162409879 0.3567881932191582 24.277504943775437 -13.999999999999998 0.3694776209845318 9.314919742592362 0.35215709753597757 0.999790005619118 0.004250662345534023 22.758811715182055 0.1972511999475103 149.84953030886444 0.01240337419967018 1.0000000000000041e-14 13.999999999999998 -8.962762645056385 GICIHTLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GICIHTLTK 9 0 Q9BZK7;A0A0D9SF63 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 61351000.0 16264000.0 26506000.0 18581000.0 False True 21322261.50080006 22551408.11957876 16658416.361537648 1.0 1.057646165662708 0.7812687392898069 24.345857126837693 -6.85228928253595 1.2241481473308173 1.0308307913704022 0.7697324803425573 0.9435481963690828 0.02828521321651228 0.154960322681667 0.4457318467570667 0.018070117322571137 0.0418771053566337 1.4051112710239698e-07 6.85228928253595 -0.261098311027845 GICIHTLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GICIHTLTK 9 0 Q9BZK7;A0A0D9SF63 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 53568000.0 16264000.0 14157000.0 23147000.0 False True 22277240.318073783 13531496.929061446 17680155.327429004 1.0 0.607413518724004 0.7936420793146847 24.409067188360584 -10.109958723811529 4.889334600680273 1.0000119779223249 0.7005277990203371 0.7751766188219309 0.07602749150656737 20082519.67193075 41525782.88753589 1878.5003085406986 0.026026235464954722 7.763208961636992e-11 10.109958723811529 -0.29948417890198775 GICIHTLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GICIHTLTK 9 0 Q9BZK7;A0A0D9SF63 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 21206500.0 12428000.0 4002500.0 4776000.0 False True 10334432.653751776 3980937.738065956 5774639.518271028 1.0 0.38521105816299755 0.5587766364875989 23.300955853160108 -10.825186476499235 10.872309584954222 1.0066376177141774 0.4719938473255748 0.9250333842353223 0.07085785063439022 0.011233657422572447 0.00018062310892716127 0.0676037185458148 0.02286927295458716 1.495593343317278e-11 10.825186476499235 -0.5346437703886026 GICIHTLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GICIHTLTK 9 0 Q9BZK7;A0A0D9SF63 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 24575600.0 9615700.0 9032800.0 5927100.0 False True 12447713.203784125 8530116.739530653 4848428.617181717 1.0 0.6852758092898127 0.38950356083941484 23.56937739023272 -7.191492299950497 0.23172690392892684 1.130902102552303 4.758640294202535e-11 0.9999774679034709 0.0011832401161005009 0.089279578913431 0.011133174962420719 0.011980730987744935 0.03745605947075151 6.434394730853759e-08 7.191492299950497 -1.1309021025047166 down GICVSLGHSVADLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GICVSLGHSVADLR 14 0 Q9Y303-2;Q9Y303-3;Q9Y303;A0A3B3IU33 Q9Y303-2 AMDHD2 Putative N-acetylglucosamine-6-phosphate deacetylase 0 23981900.0 5006000.0 12436000.0 6539900.0 False True 7594467.987622091 10216698.63708852 5247285.898460004 1.0 1.3452816778924206 0.6909352843428056 22.856517473024216 -6.763365540110898 1.60005178146117 1.199723021927613 0.6881608898673639 0.7044390379466952 0.14530389265990779 0.2773111929777931 1.4000153910403796 0.07162997244013011 0.17155374640948692 1.724385887462102e-07 6.763365540110898 -0.511562132060249 GICVSLGHSVADLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GICVSLGHSVADLR 14 0 Q9Y303-2;Q9Y303-3;Q9Y303;A0A3B3IU33 Q9Y303-2 AMDHD2 Putative N-acetylglucosamine-6-phosphate deacetylase 0 8089300.0 889900.0 2402000.0 4797400.0 False True 1218920.0786432514 2295871.6976482053 3664352.925554411 1.0 1.8835293124416173 3.006229029907447 20.217172104695763 -6.967867487855052 0.3048551740117711 0.8161866402306501 4.108995185522161 0.9999606424729338 0.005150445314872661 0.07700095792935041 0.01149416079847442 0.018191995041408112 0.10018416994170537 1.076793715336604e-07 6.967867487855052 3.2928085452915115 GIDFHK(ub)QQPLFVSGGDDYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIDFHKQQPLFVSGGDDYK 19 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ITV3;A0A3B3ISK1;A0A3B3ITX2;A0A3B3IS23 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 31795200.0 7460300.0 14455300.0 9879600.0 True False 9780525.545647979 12298625.58631809 8857353.763815053 1.0 1.2574606066839205 0.9056112294248126 23.22148055819587 -6.71056289486352 1.7933059100831499 1.1581905514255721 0.9064277684194577 0.4677361005474967 0.10848291735432072 0.37394021962148344 2.3445800811429156 0.04813490424277248 0.12219695607693809 1.9473190172712414e-07 6.71056289486352 -0.25176278300611443 GIDFHK(ub)QQPLFVSGGDDYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIDFHKQQPLFVSGGDDYK 19 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ITV3;A0A3B3ISK1;A0A3B3ITX2;A0A3B3IS23 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 30106100.0 9233700.0 6817200.0 14055200.0 True False 8940581.247771852 9539343.511228366 10373721.4730382 1.0 1.0669712904410702 1.1602960909978322 23.091937196708038 -6.966452611321488 0.3321873836731376 0.9889161828214742 1.2414162894010712 0.9999400177247028 0.0005090711856900838 0.07747153279873964 0.013140920708849202 0.0013513471741322457 0.008125800733709705 1.0803074937853672e-07 6.966452611321488 0.252500106579597 GIDFHK(ub)QQPLFVSGGDDYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIDFHKQQPLFVSGGDDYK 19 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ITV3;A0A3B3ISK1;A0A3B3ITX2;A0A3B3IS23 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 93429000.0 26476000.0 27490000.0 39463000.0 True False 40166027.65487069 22584194.71964967 31663120.75275267 1.0 0.5622710543772437 0.7883060038901576 25.25947245280437 -10.090253175836251 4.901726118437311 1.0000112763305986 0.6752885291315227 0.7334459398973612 0.09227838173125913 128343482.0761178 10.532547278271426 16334.596349760288 0.031589344526536355 8.123568074650287e-11 10.090253175836251 -0.3247227471990759 GIDFHK(ub)QQPLFVSGGDDYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIDFHKQQPLFVSGGDDYK 19 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ITV3;A0A3B3ISK1;A0A3B3ITX2;A0A3B3IS23 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 34047300.0 7460300.0 9625000.0 16962000.0 True False 10218574.517026925 9199735.674381338 12955924.943355545 1.0 0.9002954041243302 1.2678798712841453 23.284690619718763 -6.834466747118332 1.3079108923719651 0.9468672940750494 1.278699310843369 0.9145013325046448 0.04538444783970408 0.1753643120829789 0.5851023126619787 0.027232023751206487 0.06267221974571689 1.4639736261912222e-07 6.834466747118332 0.33183201676831964 GIDFHK(ub)QQPLFVSGGDDYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIDFHKQQPLFVSGGDDYK 19 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ITV3;A0A3B3ISK1;A0A3B3ITX2;A0A3B3IS23 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 32017200.0 9233700.0 12655500.0 10128000.0 True False 7678230.672268096 12587322.309579922 12245717.97341896 1.0 1.6393519349506225 1.5948619540237985 22.872342472142314 -10.219665888141357 4.909054015543537 0.9999088794823104 1.6171069444880437 0.9961169301694182 0.018162958659344586 1.8117893013071127e-05 2.8800034298143527e-06 0.01758878707265767 0.005862069700001617 6.030233261683211e-11 10.219665888141357 0.6171980650057333 GIDFHK(ub)QQPLFVSGGDDYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIDFHKQQPLFVSGGDDYK 19 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ITV3;A0A3B3ISK1;A0A3B3ITX2;A0A3B3IS23 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 79871000.0 26476000.0 21384000.0 32011000.0 True False 34273703.91998383 20193961.601953246 26185326.4605969 1.0 0.5891969437881162 0.7640063216315857 25.03059877489682 -10.200524289345175 5.4162566582942855 1.000015120709926 0.6766016327098056 0.8202525752043762 0.07136562966180719 1.3031127880462373e-05 1.9234812890763377e-06 0.06910270247319178 0.02303315793095906 6.301960992187273e-11 10.200524289345175 -0.3234134880001204 GIDPFSLDALSK(ub)EGIVALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIDPFSLDALSKEGIVALR 19 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 10721300.0 3468800.0 2758100.0 4494400.0 True False 3358684.842725122 3859423.713301491 3317181.8108901265 1.0 1.1490877810881734 0.9876430704938302 21.6794649980705 -6.664031763764124 1.9586900818203412 1.0956468727716018 0.988312018017894 0.2528251380447999 0.06341777641045733 0.4749658027420549 3.507028806176582 0.02612103342123748 0.07033243975742509 2.1675455674059287e-07 6.664031763764124 -0.10733485475370774 GIDPFSLDALSK(ub)EGIVALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIDPFSLDALSKEGIVALR 19 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 53916800.0 5501000.0 5565800.0 42850000.0 True False 8345419.176969455 4572539.504206119 34380678.71817779 1.0 0.5479101058008911 4.119706630561695 22.99255308498121 -6.875139400516313 1.106509988226963 0.7343352387566879 4.350416805925382 0.96955058428708 0.2770960327393982 0.1320245917307797 0.2990238257411691 0.1936718455032527 0.463097460919516 1.3330934650744225e-07 6.875139400516313 3.6160815671686937 up GIDPFSLDALSK(ub)EGIVALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIDPFSLDALSKEGIVALR 19 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 11908700.0 3468800.0 3083700.0 5356200.0 True False 2884460.8938955716 3067087.496033472 6476156.655729334 1.0 1.06331394629908 2.245187885692929 21.459870273504777 -6.917976197517529 0.8396096275286271 0.9719725461067833 2.4271719293843192 0.9935998535252883 0.04581233242667593 0.09937705920020423 0.1118957688967823 0.03905475298168564 0.11481535751748742 1.2078800338651727e-07 6.917976197517529 1.4551993832775358 up GIDPFSLDALSK(ub)EGIVALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIDPFSLDALSKEGIVALR 19 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 43439300.0 5501000.0 7005300.0 30933000.0 True False 7121152.940921238 6615448.896846391 25303511.39938287 1.0 0.9289856504599344 3.5532885769069646 22.76367940707366 -6.900682309696135 0.9569619288122816 0.8929244392207608 3.832585133794719 0.9869022243251042 0.1397052796884532 0.11090419685336278 0.17460838880709117 0.10935194676637873 0.2854959008824128 1.2569490970008054e-07 6.900682309696135 2.9396606945739583 up GIDVQQVSLVINYDLPTNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIDVQQVSLVINYDLPTNR 19 0 P60842;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 154883000.0 29907000.0 61488000.0 63488000.0 False True 45371105.49456924 50514985.9920633 50939568.97222106 1.0 1.1133734882900255 1.1227314921457743 25.435270476470226 -13.530961831055256 0.35835353766780786 5.4832448983714675e-06 1.1239034784708153 0.9997557604539364 0.000871742720135969 15.303444559645854 0.19248942083572018 11.529849193065898 0.0027157487914089584 2.9446804222708583e-14 13.530961831055256 1.123897995225917 GIDVQQVSLVINYDLPTNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIDVQQVSLVINYDLPTNR 19 0 P60842;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 80492000.0 29907000.0 19747000.0 30838000.0 False True 38715201.05510478 18648062.09099193 25225800.424600575 1.0 0.48167287222529087 0.6515735353846093 25.206396798562675 -10.601096032776539 7.036161270169364 1.0006762589252651 0.5666232038049505 0.8966430485948286 0.06936165528346837 0.000736877054359406 4.177609416371153e-05 0.0672558414895489 0.022386377981521054 2.5055551542970265e-11 10.601096032776539 -0.43405305512031467 GIEDIIVSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIEDIIVSKR 10 1 Q5JY65;Q9BZJ0-2;Q9BZJ0-3;Q9BZJ0 Q5JY65 CRNKL1 Crooked neck-like protein 1 1 3115970.0 707370.0 1216400.0 1192200.0 True False 684914.9265447614 1702114.8634421995 879927.0547666431 1.0 2.4851478592078267 1.2847245996019871 19.385565276124364 -6.593268375088502 2.2157143255664664 2.0031202648954785 1.2883111436676355 0.0017009468675265316 0.6430316703621405 0.6602288770855849 6.115153378888922 0.2417769788974138 0.7164628871779297 2.5511243316544824e-07 6.593268375088502 -0.7148091212278429 GIEDIIVSK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIEDIIVSKR 10 1 Q5JY65;Q9BZJ0-2;Q9BZJ0-3;Q9BZJ0 Q5JY65 CRNKL1 Crooked neck-like protein 1 1 2878060.0 689950.0 1307300.0 880810.0 True False 945043.1601976766 1249539.1633370102 672780.8188513733 1.0 1.3222032770182068 0.7119048602083383 19.8500206932745 -6.763216615240112 1.600005616438335 1.1863943993382244 0.7092831087107204 0.7041480070320175 0.13559067761487284 0.2775184780743046 1.4008504301942946 0.06683692179760463 0.1601366282038546 1.72497730179457e-07 6.763216615240112 -0.477111290627504 GIEDIIVSK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIEDIIVSKR 10 1 Q5JY65;Q9BZJ0-2;Q9BZJ0-3;Q9BZJ0 Q5JY65 CRNKL1 Crooked neck-like protein 1 1 3953490.0 707370.0 2516800.0 729320.0 True False 588209.4968043444 2503241.498854313 881817.4400053236 1.0 4.255697183493391 1.4991553941174156 19.16597055155864 -6.605422898510839 2.1699758385185506 3.1817202326379364 1.5084831681620625 0.036563523962921174 1.405257852456652 0.6254277360443179 5.573469841026645 0.5359436814760429 1.5619467229119048 2.48071630696394e-07 6.605422898510839 -1.6732370644758738 GIEILTDMSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIEILTDMSR 10 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 3760720.0 808310.0 451510.0 2500900.0 False True 782650.6414965241 631800.2975935454 1845839.2646082034 1.0 0.807257113321297 2.35844598693324 19.578008937438312 -6.875777294529731 1.1031424346483698 0.8860898551932229 2.4598237539087977 0.9701137676571261 0.1193377327899953 0.13143319250075552 0.29548574254233767 0.08362923324814618 0.2002274060298837 1.3311368476959405e-07 6.875777294529731 1.5737338987155747 up GIEILTDMSRPVELSDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIEILTDMSRPVELSDR 17 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 16139500.0 3070700.0 7263400.0 5805400.0 False True 4025717.4367011003 6179729.032511441 5204712.897329033 1.0 1.5350627881065242 1.2928659249353747 21.940814483020038 -10.151266980431721 4.598927148922083 0.999949674584168 1.4139643565251894 0.7957174471885634 0.09887645537023186 5.2445255710309816e-05 9.678801093419071e-06 0.09574864862318062 0.03191223874486759 7.058834823989594e-11 10.151266980431721 0.4140146819410214 GIEILTDMSRPVELSDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIEILTDMSRPVELSDR 17 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 25792300.0 8546700.0 4150600.0 13095000.0 False True 8275389.686727058 5807956.2250930555 9665026.658420727 1.0 0.7018347709242584 1.1679240524373753 22.980395819113696 -6.73391971322879 1.7088873930034478 0.8213506178902151 1.1678529266966111 0.5773191422342058 0.12530815633134926 0.32895993110308513 1.8837171009373743 0.05806705542561476 0.14345727761444318 1.8453565334005135e-07 6.73391971322879 0.346502308806396 GIEILTDMSRPVELSDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIEILTDMSRPVELSDR 17 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 19139300.0 3070700.0 6629900.0 9438700.0 False True 4206020.77254729 6336969.09585255 7209473.456128399 1.0 1.506642367820427 1.7140841298703644 22.00402454454293 -11.167145082126552 0.1676423149319058 1.6580614080548549e-18 1.9392563653364938 0.9995398022969981 0.006434211836851012 3.490455893697165 0.09879297842941955 1.487489264642084 0.16721890410055415 6.805419761805432e-12 11.167145082126552 1.9392563653364938 GIEILTDMSRPVELSDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIEILTDMSRPVELSDR 17 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 15674200.0 8546700.0 2630200.0 4497300.0 False True 7106959.733007755 2616030.5905461735 5437664.636834236 1.0 0.3680941905997034 0.7651182560637567 22.760801094547972 -10.174499328040676 5.4041652290539535 1.0000149878950297 0.5666062233317679 0.6137212880477989 0.16208439599902627 2.9270293141215338e-05 4.471072782395307e-06 0.15694296273529865 0.05231251386531434 6.691148553286836e-11 10.174499328040676 -0.43340876456326183 GIEK(ub)PPFELPDFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIEKPPFELPDFIK 14 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 4969700.0 1019300.0 2280400.0 1670000.0 True False 1396162.7555467647 2179644.387725629 1275580.3947296161 1.0 1.561167835960527 0.9136330199770111 20.41303570065222 -6.677520880614394 1.9105654452013237 1.3558454100042399 0.916137362958546 0.31283076421953837 0.2379665618783213 0.4440794369693176 3.1318263790102328 0.10001880901143306 0.26464628223299874 2.101256739472761e-07 6.677520880614394 -0.4397080470456939 GIEK(ub)PPFELPDFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIEKPPFELPDFIK 14 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 6242500.0 1820500.0 2971200.0 1450800.0 True False 1513826.411824519 2955193.555862975 1754155.5722587095 1.0 1.9521350220738105 1.1587560889128212 20.529768352482783 -10.136736622989996 4.3808864583676925 0.9999193772447256 1.5554455553453688 0.3952304050517348 0.3238955933159521 48381672.72816873 55974134.52622774 34583.223525600915 0.11087807902208402 7.299000224527738e-11 10.136736622989996 0.5555261781006432 GIEKPPFELPDFIK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIEKPPFELPDFIKR 15 2 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 29886200.0 9186800.0 11277000.0 9422400.0 True False 12043983.765097745 9594515.55740172 8447460.434042977 1.0 0.7966230895466384 0.7013842428551647 23.52180933268162 -13.999999999998726 0.10126794439901753 2.0007592483451835 0.5024647113722703 0.999787348732424 0.0018161822757066916 12.070856516367689 0.09502396707711927 2.516561333191014 0.1772849117054682 1.0000000000029327e-14 13.999999999998726 -1.4982945369729133 GIEKPPFELPDFIK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIEKPPFELPDFIKR 15 2 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 60888000.0 19706000.0 22254000.0 18928000.0 True False 19080443.816519056 31140138.253076904 13970188.972171653 1.0 1.632044754960944 0.7321731667518574 24.185591393439886 -6.717948383039529 1.7669176839948533 1.385370104074907 0.7337548214286933 0.5027453653320719 0.26603541327078356 0.35930530681286477 2.1911847935754607 0.1196086739812062 0.3009645206191827 1.9144834525365255e-07 6.717948383039529 -0.6516152826462136 GIEKPPFELPDFIK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIEKPPFELPDFIKR 15 2 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 52049000.0 23119000.0 13162000.0 15768000.0 True False 35073213.22529669 10813138.264824612 12651447.888640104 1.0 0.3083018996681375 0.3607153928946321 25.063866273069863 -10.318531287292906 8.777360763317162 1.000000694457507 0.3345086462813848 0.9953692971714456 0.0213977190069557 2.9081882609740496e-07 2.2545933200708944e-08 0.020718273946914535 0.006906084113397109 4.8025148088227186e-11 10.318531287292906 -0.6654920481761222 GIEKPPFELPDFIK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIEKPPFELPDFIKR 15 2 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 29532100.0 9186800.0 11788000.0 8557300.0 True False 12583408.223935071 11267167.182296854 6536241.983125601 1.0 0.8953986854583182 0.5194333575456073 23.58501939420451 -6.947333964348537 0.5873846459968635 1.004380660780964 0.3916181460200239 0.9989751076555499 0.006606183929671543 0.08457429222794326 0.04053153919140758 0.006867470674436117 0.03147215370435845 1.1289274566638966e-07 6.947333964348537 -0.6127625147609401 GIEKPPFELPDFIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIEKPPFELPDFIKR 15 2 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 51814000.0 19706000.0 21434000.0 10674000.0 True False 16386412.123819815 21318530.787684135 12905884.049000207 1.0 1.3009883204813844 0.7875966960601338 23.965996668874162 -6.74781101340285 1.6578770198076263 1.177451329755969 0.7867415096572214 0.6394909987147206 0.1264665380558478 0.3038969339829077 1.642704091174068 0.060276376665461935 0.14667660443375397 1.7872651478855696e-07 6.74781101340285 -0.39070982009874755 GIEKPPFELPDFIK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIEKPPFELPDFIKR 15 2 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 64496000.0 23119000.0 11613000.0 29764000.0 True False 29928001.243620858 10966726.341352567 24347257.40442992 1.0 0.3664369782693096 0.8135276795211818 24.834992595162312 -9.841993419856959 5.902304350567382 1.0000000599646501 0.5899823288947218 0.52860862357655 0.18252401447061412 1.4422202395995198e-07 2.8108964178634576e-08 0.17672814341533868 0.05890937236030558 1.4388203781464043e-10 9.841993419856959 -0.41001773106992834 GIFAIIKPFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIFAIIKPFLK 11 1 Q5QPC2;Q9BTX7 Q5QPC2 TTPAL Alpha-tocopherol transfer protein-like 0 3401390.0 615340.0 1795860.0 990190.0 False True 806716.6989610359 1527924.6882074506 887734.6373731756 1.0 1.8940040415368278 1.1004292318684887 19.621702594331722 -10.165795622513325 4.227650923432487 0.999863851847737 1.4972166363075377 0.343584268805339 0.323975559614382 228778453.17221236 201826935.78467846 380866.8953407007 0.11856291008852972 6.82659875947501e-11 10.165795622513325 0.4973527844598007 GIFAIIKPFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIFAIIKPFLK 11 1 Q5QPC2;Q9BTX7 Q5QPC2 TTPAL Alpha-tocopherol transfer protein-like 0 17351200.0 6942600.0 4193800.0 6214800.0 False True 6722210.963187108 5868406.210378087 4586957.439996423 1.0 0.8729875099896868 0.6823584480040884 22.680504388787703 -6.965247595679524 0.35377718492647015 1.017639565554779 0.5312363885726038 0.9999181568906114 0.0011809504172659163 0.07787704186503565 0.0145642482760112 0.0025926231299504853 0.016344872663398548 1.0833091324358538e-07 6.965247595679524 -0.48640317698217517 GIFAIIKPFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIFAIIKPFLK 11 1 Q5QPC2;Q9BTX7 Q5QPC2 TTPAL Alpha-tocopherol transfer protein-like 0 20454500.0 8682500.0 5156600.0 6615400.0 False True 13171987.275774814 4236364.441300305 5307863.290367172 1.0 0.32161923274034665 0.4029660201789823 23.650969687605336 -10.601149478086256 6.506224604556153 1.0016203556930607 0.36229262646349664 0.9879432238171174 0.033209686906550254 0.0007820805689896879 4.7943720351786506e-05 0.03221779970593931 0.010718380360152643 2.5052468337046605e-11 10.601149478086256 -0.639327729229564 GIFAIIKPFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIFAIIKPFLK 11 1 Q5QPC2;Q9BTX7 Q5QPC2 TTPAL Alpha-tocopherol transfer protein-like 0 5902030.0 615340.0 1656000.0 3630690.0 False True 842847.8269382379 1582832.4443403115 2773195.7984077055 1.0 1.8779575550312217 3.290268669828248 19.684912655854614 -6.964069516506849 0.37368284891359316 0.8958270049550967 4.321845041772885 0.9998926538591898 0.00977482119421612 0.07827820567952236 0.015982405587066453 0.018517646427111924 0.11971437872097047 1.0862517359135419e-07 6.964069516506849 3.426018036817789 GIFAIIKPFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIFAIIKPFLK 11 1 Q5QPC2;Q9BTX7 Q5QPC2 TTPAL Alpha-tocopherol transfer protein-like 0 14378400.0 6942600.0 2881600.0 4554200.0 False True 5773079.509328702 2866076.2488471824 5506462.163758354 1.0 0.4964553570093566 0.9538171360467975 22.46090966422198 -10.429025261344927 8.805172064113638 1.000002579803661 0.7251362465280772 0.32503756086694 0.1867171644155463 9.456112292507989e-06 6.131376758332615e-07 0.18078981107020167 0.060262705686040245 3.723700462009689e-11 10.429025261344927 -0.27486633327558374 GIFAIIKPFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIFAIIKPFLK 11 1 Q5QPC2;Q9BTX7 Q5QPC2 TTPAL Alpha-tocopherol transfer protein-like 0 16952200.0 8682500.0 5186500.0 3083200.0 False True 11239667.407661993 4897866.71570008 2522089.236303533 1.0 0.43576616087067155 0.2243918031403887 23.422096009697785 -12.369377934438752 0.15948488845257153 2.6526615404328657 4.939455384980546e-14 0.9995474588622891 0.006964386055105648 6.355279928188762 0.11106461913336539 3.585114143251985 0.18600112530838322 4.2719097157223435e-13 12.369377934438752 -2.6526615404328164 GIFEPFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIFEPFGR 8 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;A0A0U1RQW2 Q14498-3 RBM39 RNA-binding protein 39 0 4677670.0 575670.0 1787800.0 2314200.0 False True 754708.944796211 1521067.208789818 2074748.7833738995 1.0 2.015435512296123 2.7490714104814673 19.525560847540532 -7.743995488979426 0.15547369180304155 3.132278311507226e-18 4.2136144986189255 0.9999647522573101 0.004257630498210637 0.13551534714679692 0.020403505320414624 0.20252142782792804 0.29761717703775176 1.8030364689178448e-08 7.743995488979426 4.2136144986189255 GIFEPFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIFEPFGR 8 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;A0A0U1RQW2 Q14498-3 RBM39 RNA-binding protein 39 0 3517870.0 575670.0 1544600.0 1397600.0 False True 788510.7558967991 1476354.4646908462 1067515.6644755173 1.0 1.8723326900109813 1.35383779674812 19.588770909063424 -10.40671835084479 5.216181163816039 0.9995069893542423 1.6130852433795706 0.6508618425589445 0.21167465378887623 0.0012145440132416494 0.00013814079236641342 0.20511063707183944 0.0683177007448681 3.919960123961034e-11 10.40671835084479 0.6135782540253283 GIFFSHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIFFSHR 7 0 P23381;P23381-2;G3V3Y5;G3V3H8;G3V277;G3V423;G3V456;G3V5U1;G3V227;G3V3P2;G3V2Y7 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 39304000.0 11664000.0 10401000.0 17239000.0 False True 15291616.954336688 8849211.342780454 15455273.64816467 1.0 0.5786969010017496 1.01070237989329 23.866237631319898 -10.951610439688732 11.288488204933953 1.0583639570443995 0.7946996404475205 0.2314314005410345 0.17636549822849376 0.10104899867345815 0.00043315902436206886 0.06660936584646894 0.056921719790377495 1.1178655188337588e-11 10.951610439688732 -0.26366431659687894 GIFFSHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIFFSHR 7 0 P23381;P23381-2;G3V3Y5;G3V3H8;G3V277;G3V423;G3V456;G3V5U1;G3V227;G3V3P2;G3V2Y7 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 20342400.0 7522600.0 2467800.0 10352000.0 False True 7283799.180663052 3453205.4094069917 7640500.646656853 1.0 0.4740939891059219 1.048971897377507 22.7962597160959 -6.666054657007461 1.9512652906273216 0.6631834899069347 1.0466162538816153 0.2616942186552159 0.22359880562429227 0.4702632558494568 3.447968067373054 0.09237644816994461 0.2480919172559745 2.1574728689046568e-07 6.666054657007461 0.3834327639746806 GIFFSHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIFFSHR 7 0 P23381;P23381-2;G3V3Y5;G3V3H8;G3V277;G3V423;G3V456;G3V5U1;G3V227;G3V3P2;G3V2Y7 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 11363800.0 5934200.0 2925800.0 2503800.0 False True 9002615.248131651 2403668.1306202635 2008922.8325454758 1.0 0.2669966520138808 0.22314880478340954 23.101912732703212 -13.630168469635517 0.40400881478073086 9.999999998219154 0.22076799498150626 0.9998366210245748 0.00455454833812654 20.051478472050704 0.20948689114442576 156.614963343759 0.011100640778083716 2.3433196285804883e-14 13.630168469635517 -9.779232003237649 GIFFSHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIFFSHR 7 0 P23381;P23381-2;G3V3Y5;G3V3H8;G3V277;G3V423;G3V456;G3V5U1;G3V227;G3V3P2;G3V2Y7 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 33996000.0 11664000.0 11012000.0 11320000.0 False True 15976496.007747948 10525453.428185696 8646449.142718118 1.0 0.6588086288183141 0.5411980911537138 23.92944769284279 -13.999999999999998 0.14859439686130602 2.6463360952079134 0.40968848947072467 0.9995709987589368 0.004030148360202396 11.952709354897863 0.12132798242259077 5.68426160521572 0.11837774084230446 1.0000000000000041e-14 13.999999999999998 -2.236647605737189 GIFFSHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIFFSHR 7 0 P23381;P23381-2;G3V3Y5;G3V3H8;G3V277;G3V423;G3V456;G3V5U1;G3V227;G3V3P2;G3V2Y7 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 19090200.0 7522600.0 6495600.0 5072000.0 False True 6255375.207685315 6460606.913524342 6132531.749721652 1.0 1.0328088562276616 0.9803619361133225 22.576664991530176 -6.737578417445781 1.6956489885720567 1.019575829321853 0.9803476753789535 0.5939817170544557 0.01378588238985318 0.3222169127617954 1.8181427465996032 0.006434381261711248 0.015831033214199357 1.829875668928883e-07 6.737578417445781 -0.03922815394289958 GIFFSHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIFFSHR 7 0 P23381;P23381-2;G3V3Y5;G3V3H8;G3V277;G3V423;G3V456;G3V5U1;G3V227;G3V3P2;G3V2Y7 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 18571500.0 5934200.0 6130500.0 6506800.0 False True 7681938.880569874 5789332.2858573925 5322629.165406026 1.0 0.7536290480650009 0.6928757502703763 22.87303905479566 -13.999999999728281 0.1966260386512833 2.3523413034081453 0.6520817251864074 0.999487105990406 0.0030074653177611173 12.46625170199839 0.14061481322135166 6.47473256948893 0.03968099347911626 1.0000000006256554e-14 13.999999999728281 -1.700259578221738 GIFHFQLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIFHFQLGR 9 0 A0A0J9YWJ4;K7EJD2;A0A0J9YWB6;A0A0A0MR03;Q9Y5B0-4;Q9Y5B0 A0A0J9YWJ4 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 0 40869000.0 10858000.0 15152000.0 14859000.0 False True 14234943.149021568 12891380.662033407 13321533.217592617 1.0 0.9056151842039137 0.935833257508181 23.762933395522243 -10.227150596542916 6.391577594996733 1.000000910780063 0.9207242214108651 0.9017362385800923 0.012336476767579008 1.6010926206422468e-07 1.9368498300256697e-08 0.011944879586984678 0.0039815807559756625 5.927197566347371e-11 10.227150596542916 -0.07927668936919785 GIFHFQLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIFHFQLGR 9 0 A0A0J9YWJ4;K7EJD2;A0A0J9YWB6;A0A0A0MR03;Q9Y5B0-4;Q9Y5B0 A0A0J9YWJ4 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 0 36345100.0 10876000.0 9487100.0 15982000.0 False True 10530747.333221424 13275348.504572913 11795834.750277225 1.0 1.260627388019564 1.1201327291430514 23.328104487628753 -10.18625253222162 4.150926394395576 0.9999209007015966 1.1903800585725284 0.7100007888380861 0.05735670437235515 40266178.244709864 4.642292540319438 30698.33889003677 0.019634725495775364 6.512495973248687e-11 10.18625253222162 0.19045915787093182 GIFHFQLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIFHFQLGR 9 0 A0A0J9YWJ4;K7EJD2;A0A0J9YWB6;A0A0A0MR03;Q9Y5B0-4;Q9Y5B0 A0A0J9YWJ4 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 0 127783000.0 45181000.0 35593000.0 47009000.0 False True 68542880.17354254 29241151.060621705 37717650.5452234 1.0 0.4266110642941548 0.550278168202543 26.0305034794241 -9.824052287987458 6.505252766155705 1.0000000114565917 0.48844461624858715 0.9580092128295989 0.05048688375750079 8.378612498295759e-09 1.5116593000675508e-09 0.04888371572697433 0.016294571666183904 1.4995042880056644e-10 9.824052287987458 -0.5115553952080045 GIFHFQLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIFHFQLGR 9 0 A0A0J9YWJ4;K7EJD2;A0A0J9YWB6;A0A0A0MR03;Q9Y5B0-4;Q9Y5B0 A0A0J9YWJ4 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 0 47429000.0 10858000.0 11332000.0 25239000.0 False True 14872496.026416926 10831314.770087194 19278068.01352144 1.0 0.7282782090409251 1.2962227711662668 23.826143457045134 -6.776588639583311 1.5489684913472628 0.8454633834393955 1.3002649882639574 0.7552005539590803 0.11475462550620132 0.25591044319048933 1.2124895797298179 0.05836295266223929 0.13812102506579588 1.67267420844473e-07 6.776588639583311 0.4548016048245619 GIFHFQLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIFHFQLGR 9 0 A0A0J9YWJ4;K7EJD2;A0A0J9YWB6;A0A0A0MR03;Q9Y5B0-4;Q9Y5B0 A0A0J9YWJ4 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 0 23581800.0 10876000.0 4882200.0 7823600.0 False True 9043875.888494086 4855898.619559174 9459478.587760719 1.0 0.5369267202944489 1.0459540471796365 23.10850976306303 -6.667278425572618 1.9471711631312485 0.7037288568881306 1.0438664672462166 0.26696555796366384 0.19682854863855145 0.4674082358694529 3.413948366753601 0.08145767336090688 0.21839783612301833 2.1514020317362865e-07 6.667278425572618 0.340137610358086 GIFHFQLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIFHFQLGR 9 0 A0A0J9YWJ4;K7EJD2;A0A0J9YWB6;A0A0A0MR03;Q9Y5B0-4;Q9Y5B0 A0A0J9YWJ4 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 0 127666000.0 45181000.0 51443000.0 31042000.0 False True 58487695.15065679 48580151.82796864 25392674.5178173 1.0 0.8306046545830266 0.43415413194876346 25.80162980151655 -6.956859647087684 0.4776415091446541 1.0097303817887064 0.23856513981034266 0.9996354053442342 0.004527724316026425 0.08084262473968244 0.02542579629738292 0.005563371935669486 0.03270683929536531 1.1044354876463167e-07 6.956859647087684 -0.7711652419783638 down GIFLHLSNQHEFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIFLHLSNQHEFGR 14 0 O60568;H7C2S8 O60568 PLOD3 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 0 33695600.0 9383600.0 12892000.0 11420000.0 False True 12301990.470911678 10968563.852622418 10238367.94837523 1.0 0.8916088724469283 0.8322529571603939 23.55238842775848 -13.999999999879966 0.07281965588460418 1.6135965111506627 0.6288004904893638 0.9999145279886577 0.0006420549574911505 12.331127899761833 0.0737717166156078 1.264212617143833 0.18658722900378955 1.000000000276388e-14 13.999999999879966 -0.9847960206612989 GIFLHLSNQHEFGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIFLHLSNQHEFGR 14 0 O60568;H7C2S8 O60568 PLOD3 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 0 29514900.0 9832900.0 7577000.0 12105000.0 False True 9520759.971757332 10602535.613533001 8934337.357784119 1.0 1.1136228247518771 0.9384059029202716 23.182645307114253 -6.731671126507605 1.7172597550200093 1.0682497962468602 0.9384800378980229 0.5669732081071468 0.04775820200272849 0.33309870640810463 1.925192271328127 0.022032727709384265 0.05456702651526756 1.8549357588712646e-07 6.731671126507605 -0.1297697583488373 GIFLHLSNQHEFGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIFLHLSNQHEFGR 14 0 O60568;H7C2S8 O60568 PLOD3 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 0 61291000.0 23159000.0 18264000.0 19868000.0 False True 35133896.14968834 15004646.502716698 15941081.09154626 1.0 0.4270703835062653 0.4537236924600993 25.066360236335623 -10.582223648338713 6.394143240651175 1.001192774015549 0.4403970379831837 0.9983015007186697 0.010881167815607903 0.00018535665395895214 1.211070797400133e-05 0.010554835571532771 0.0035118818114281297 2.6168350713702033e-11 10.582223648338713 -0.5607957360323654 GIFLHLSNQHEFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIFLHLSNQHEFGR 14 0 O60568;H7C2S8 O60568 PLOD3 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 0 54182600.0 9383600.0 12968000.0 31831000.0 False True 12852970.50225512 12395030.880558671 24313173.38002303 1.0 0.9643709116413128 1.891638464101132 23.61559848928137 -6.897965665192212 0.9740634404398723 0.9592661053920847 1.985039587982284 0.9855259583383545 0.05160820169866804 0.11291751295267649 0.18599632322039392 0.03988509763839577 0.10275186431959783 1.2648363399826663e-07 6.897965665192212 1.0257734825901994 GIFLHLSNQHEFGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIFLHLSNQHEFGR 14 0 O60568;H7C2S8 O60568 PLOD3 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 0 58209000.0 23159000.0 19518000.0 15532000.0 False True 29979782.03213869 18431806.14229909 12705335.371778198 1.0 0.6148078769398646 0.4237967893881925 24.837486558428072 -13.067046037708538 0.10017773746333085 2.6102594654061404 1.0520548615261036e-15 0.9998228246964985 0.0031898451082319024 8.70499673186991 0.08471375472286523 3.1471314434581554 0.3501482407112152 8.569469991133722e-14 13.067046037708538 -2.6102594654061395 GIFNGFSVTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIFNGFSVTLK 11 0 Q00325-2;Q00325;F8VVM2;F8VZL5;F8VWR4;F8VWQ0 Q00325-2 SLC25A3 Phosphate carrier protein, mitochondrial 0 65870000.0 16345000.0 24074000.0 25451000.0 False True 21428453.285205133 20482253.039717004 22817574.663230993 1.0 0.9558437450946861 1.0648260217168801 24.353024383647586 -6.796735139319317 1.4693505720084787 0.9755348327430204 1.0662093115492806 0.8223862308579611 0.018862826590581337 0.2254631355499156 0.9613354526592275 0.010101165297707769 0.023538349385178337 1.5968527137255552e-07 6.796735139319317 0.09067447880626012 GIFNGFSVTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIFNGFSVTLK 11 0 Q00325-2;Q00325;F8VVM2;F8VZL5;F8VWR4;F8VWQ0 Q00325-2 SLC25A3 Phosphate carrier protein, mitochondrial 0 67483000.0 25000000.0 24821000.0 17662000.0 False True 24206388.68430811 34732154.73980504 13035792.351357533 1.0 1.434834216403387 0.5385269368911703 24.5288845260408 -6.774786931573609 1.5560261584708799 1.2478882578033754 0.5325380020795097 0.7485232670047026 0.18352453416283837 0.2587829632695805 1.2371339345465135 0.09292900594386762 0.22026222806161613 1.6796278551845666e-07 6.774786931573609 -0.7153502557238657 GIFNGFSVTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIFNGFSVTLK 11 0 Q00325-2;Q00325;F8VVM2;F8VZL5;F8VWR4;F8VWQ0 Q00325-2 SLC25A3 Phosphate carrier protein, mitochondrial 0 64799000.0 18209000.0 21731000.0 24859000.0 False True 27624384.256214656 17852933.26492206 19945607.753913246 1.0 0.6462744327380143 0.7220290439388195 24.71943897159684 -10.130985446650268 7.326056042389689 1.0000001358404207 0.6841517383384169 0.9586402318992964 0.030926690517483365 6.859870699298385e-08 8.131124218693979e-09 0.029944652048707672 0.009981546443960319 7.396300598874962e-11 10.130985446650268 -0.3158483975020038 GIFNGFSVTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIFNGFSVTLK 11 0 Q00325-2;Q00325;F8VVM2;F8VZL5;F8VWR4;F8VWQ0 Q00325-2 SLC25A3 Phosphate carrier protein, mitochondrial 0 74085000.0 16345000.0 18564000.0 39176000.0 False True 22388188.20701644 17743781.097061303 29923435.655046355 1.0 0.7925510064945951 1.3365724541152633 24.416234445170478 -6.803373468295235 1.4422514044226982 0.8860271240456307 1.344709647099507 0.8418044411057135 0.08916150472091772 0.21597717824449428 0.8865715797851734 0.04862827747942018 0.11285942924147019 1.5726299114749376e-07 6.803373468295235 0.45868252305387636 GIFNGFSVTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIFNGFSVTLK 11 0 Q00325-2;Q00325;F8VVM2;F8VZL5;F8VWR4;F8VWQ0 Q00325-2 SLC25A3 Phosphate carrier protein, mitochondrial 0 57507970.0 25000000.0 13582000.0 18925970.0 False True 20788607.687785182 13508831.070184078 22883302.823201805 1.0 0.6498189428107539 1.1007616848071748 24.309289801475078 -6.699439217618321 1.8329619644128063 0.7824287939612317 1.0994012943714624 0.41484566422325453 0.14783149897949155 0.3967055723152308 2.590847244894399 0.0643531188577408 0.16560821234400627 1.9978403598329557e-07 6.699439217618321 0.31697250041023073 GIFNGFSVTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIFNGFSVTLK 11 0 Q00325-2;Q00325;F8VVM2;F8VZL5;F8VWR4;F8VWQ0 Q00325-2 SLC25A3 Phosphate carrier protein, mitochondrial 0 46685000.0 18209000.0 16030000.0 12446000.0 False True 23571909.453051236 15137916.408497518 10180955.706744216 1.0 0.6422015339337734 0.4319105215901954 24.49056529368929 -9.467370015228322 0.1273487705060179 1.6375973044402963 8.403053507996213e-12 0.9998813485241946 0.0025544807914907384 0.9181711982702248 0.04958621358405932 0.4144980422189787 0.20873966366857147 3.409023419437085e-10 9.467370015228322 -1.6375973044318932 GIFPVLCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIFPVLCK 8 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 100117000.0 17942000.0 31064000.0 51111000.0 False True 23522135.750575155 26429372.286523636 45822524.01133155 1.0 1.1235957723727275 1.9480596701433082 24.487515723402602 -6.933636303108541 0.7163161720259734 0.9889953157124663 2.1341364528146425 0.9972059038810543 0.022244411175610407 0.09079308615911395 0.06874958648044267 0.020723427335371403 0.07316546468477346 1.1651013269733309e-07 6.933636303108541 1.145141137102176 GIFPVLCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIFPVLCK 8 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 38203300.0 21151000.0 5897300.0 11155000.0 False True 20479573.082472056 8252122.644013235 8233170.857173219 1.0 0.4029440755811466 0.4020186760738572 24.28768230541761 GIFPVLCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIFPVLCK 8 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 92652600.0 9569700.0 77849000.0 5233900.0 False True 14517934.53878289 63956237.712986745 4199417.370900142 1.0 4.4053262220004825 0.2892572190404848 23.791332880450522 -6.687018180214077 1.8770345731828684 3.1408944596742696 0.304013830251506 0.356445629209582 1.4411038884308829 0.4231415660478479 2.888087005944936 0.6147356110880433 1.6068432809038413 2.0558045351420106e-07 6.687018180214077 -2.8368806294227635 GIFPVLCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIFPVLCK 8 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 115948000.0 17942000.0 48326000.0 49680000.0 False True 24575642.264318712 46190797.52728856 37946607.19171695 1.0 1.8795357220166253 1.5440738754083954 24.550725784925493 -10.004606387284992 5.0612707097472915 0.9999934776514615 1.711804798718488 0.8572057320503537 0.13695172541443038 1.0079542187394605e-05 1.9817243684183478e-06 0.13260415037389756 0.0442009793107277 9.894494529255716e-11 10.004606387284992 0.7118113210670264 GIFPVLCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIFPVLCK 8 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 35096500.0 21151000.0 2904500.0 11041000.0 False True 17587993.648173794 2888852.882001886 13349622.052183907 1.0 0.1642514171763897 0.7590190398761051 24.068087580851888 -10.265948080409489 7.37389801523415 1.0000020809068906 0.46163522856196193 0.5220889135186726 0.2428128651904147 8.306710672782536e-06 8.266714324911976e-07 0.235103456345512 0.07836751526061521 5.4206569008850034e-11 10.265948080409489 -0.5383668523449286 GIFPVLCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIFPVLCK 8 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 26085200.0 9569700.0 8872500.0 7643000.0 False True 12388165.296988558 8378737.575445686 6252052.423802517 1.0 0.6763501595738697 0.5046794479988357 23.56245920254297 -13.764337431713859 0.08131073927195658 2.6773877049266885 3.118991155061965e-07 0.9998888073911429 0.0021654931390309782 11.25832734840064 0.0778811885608296 3.4510846455125037 0.44577573534713133 1.72053126255523e-14 13.764337431713859 -2.677387393027573 GIFTSEIGTK(ub)QITQSALLAEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIFTSEIGTKQITQSALLAEAR 22 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 13848300.0 6073500.0 4594300.0 3180500.0 True False 7962417.315857661 3908848.348441138 2851412.3695102828 1.0 0.49091226864691173 0.3581088828177234 22.924775055390572 -13.999999999999998 0.18864711203247808 3.7163837903324755 0.26152659942952977 0.9994902087102844 0.006246420117260712 12.328997249274355 0.137734397685049 12.30505464896997 0.09232282863761183 1.0000000000000041e-14 13.999999999999998 -3.4548571909029455 GIFTSEIGTK(ub)QITQSALLAEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIFTSEIGTKQITQSALLAEAR 22 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 40533000.0 6647000.0 11911000.0 21975000.0 True False 6435994.623383849 16667124.41504444 16219088.264131011 1.0 2.5896734522567666 2.5200593246616965 22.617731690161683 -10.121945830655134 4.564447440675892 0.9998477479804462 2.554866388498352 0.9984988728386882 0.02841984871500142 9912827.798134103 4.885489903963418 15909.737374753076 0.00972887011905054 7.551864158349665e-11 10.121945830655134 1.5550186405179056 GIFTSEIGTK(ub)QITQSALLAEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIFTSEIGTKQITQSALLAEAR 22 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 24032200.0 6073500.0 5169700.0 12789000.0 True False 8319037.080166071 4941285.560088223 9768501.597722806 1.0 0.5939732582595462 1.174234650427571 22.987985116913464 -6.718596164634085 1.7643683495734142 0.7526101228196356 1.173259895384416 0.5058972520513999 0.1708873888345135 0.35804520543591173 2.177514353005511 0.07692698620808791 0.19343495492508014 1.9116299907599902e-07 6.718596164634085 0.4206497725647804 GIFTSEIGTK(ub)QITQSALLAEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIFTSEIGTKQITQSALLAEAR 22 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 32351000.0 6647000.0 12920000.0 12784000.0 True False 5527275.012028331 12850397.395580797 15457075.293462474 1.0 2.324906462518339 2.796509176732682 22.39813696559596 -9.853770989401992 0.26598526509195214 3.4903144440616426e-23 3.030658933891931 0.9989992902935457 0.024057628411879788 1.2707674770218276 0.11623335970550713 1.1834331658982808 0.1942216791125809 1.400325542526436e-10 9.853770989401992 3.030658933891931 GIFVIGFSYPVVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIFVIGFSYPVVPK 14 0 O75600;O75600-2 O75600 GCAT 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial 0 11974400.0 6277800.0 3557800.0 2138800.0 False True 6078514.675293977 4978448.093681904 1578584.1173753531 1.0 0.8190237845302445 0.25969898925990625 22.535287404115014 -6.950779897052923 0.5502151389303765 1.0077254446825834 0.04471137751204343 0.9992610727377325 0.008565669768379093 0.08317408517562985 0.03467796437893448 0.009294406096893542 0.04640261171070696 1.1200053648291648e-07 6.950779897052923 -0.96301406717054 down GIFVIGFSYPVVPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIFVIGFSYPVVPK 14 0 O75600;O75600-2 O75600 GCAT 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial 0 46354000.0 12546000.0 12434000.0 21374000.0 False True 19033199.23545879 10215055.55271458 17149419.531442992 1.0 0.5366967174747986 0.901026638732057 24.18201474464662 -10.490151982356947 6.442431758183704 1.0001459684470146 0.7188616781034283 0.44256859067753673 0.14873706751810958 0.00031199894622553083 2.4691587619133055e-05 0.14408814096282518 0.04800468212178052 3.234804343944442e-11 10.490151982356947 -0.2812842903435864 GIFVIGFSYPVVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIFVIGFSYPVVPK 14 0 O75600;O75600-2 O75600 GCAT 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial 0 6205300.0 1028600.0 1704700.0 3472000.0 False True 1408901.2168698148 1629380.717310946 2651985.1080845706 1.0 1.1564903896747105 1.8823073444258507 20.426139031980945 -6.941495017644221 0.6455131228054102 0.992016655468297 2.0869514611735824 0.9983531470377175 0.015598890113528142 0.08709131418794555 0.0515546283981954 0.015362140827169364 0.06206976101382171 1.1442080064370792e-07 6.941495017644221 1.0949348057052855 GIFVIGFSYPVVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIFVIGFSYPVVPK 14 0 O75600;O75600-2 O75600 GCAT 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial 0 11658300.0 6277800.0 2099200.0 3281300.0 False True 5220268.853695111 2087891.192941425 3967404.658982977 1.0 0.3999585560547391 0.7600000632485991 22.31569267954929 -10.329887968209352 6.304174854743944 1.0000250476660117 0.579979309651717 0.6447065928522391 0.14698632980792636 5.174883152873058e-05 5.500944102786865e-06 0.14232737132972245 0.047439633955520775 4.678558150856723e-11 10.329887968209352 -0.4200457380142948 GIFVIGFSYPVVPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIFVIGFSYPVVPK 14 0 O75600;O75600-2 O75600 GCAT 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial 0 37075000.0 12546000.0 12823000.0 11706000.0 False True 16241044.318632592 12109388.777677078 9575628.11370303 1.0 0.7456040720105999 0.5895943589487874 23.953141066739068 -10.241565420212472 0.07916594224772004 1.8706689311790374 1.43933535087972e-11 0.9999662050867769 0.0009832780833707367 1.990067706034465 0.04004023474777217 0.6547224684652204 0.3208694590532593 5.733694901798234e-11 10.241565420212472 -1.870668931164644 GIGEHQK(ub)TQGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIGEHQKTQGLR 12 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 174061410.0 38180900.0 68793000.0 67087510.0 True False 50055529.64436161 58529352.55301378 60145938.01403702 1.0 1.169288447627218 1.2015842893156166 25.577026116885975 -13.82973419520801 0.2347870027223511 4.035546850291149e-06 1.2166962274884645 0.9995074963798597 0.0019618963015769373 12.420574562795062 0.15265503361385266 5.796622504817365 0.01629339548681667 1.4800139360188892e-14 13.82973419520801 1.2166921919416143 GIGEHQK(ub)TQGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIGEHQKTQGLR 12 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 245973790.0 62680000.0 81025750.0 102268040.0 True False 60690257.70929732 113379754.51870424 75480972.34856352 1.0 1.8681705894508873 1.2437082193671485 25.854961610963933 -9.894692363247225 5.688111946345063 0.9999997129803375 1.5559394044100903 0.513801127290437 0.2549356950494893 9.278528824554569e-07 1.7976846027348084e-07 0.2468405503740185 0.08228014177282175 1.2744054989862712e-10 9.894692363247225 0.5559396914297527 GIGEHQK(ub)TQGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIGEHQKTQGLR 12 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 336368100.0 46125000.0 50902000.0 239341100.0 True False 69974997.18918684 41818140.40085876 192035226.67806938 1.0 0.5976154638177087 2.7443406129603156 26.06033618805837 -6.8582527463151255 1.1946223321453249 0.7826300947408421 2.8448308672832425 0.9514683413925102 0.20525893368845813 0.14861611539089267 0.4040299496095972 0.13410597222951334 0.3124349935090746 1.3859490135181745e-07 6.8582527463151255 2.0622007725424005 up GIGEHQK(ub)TQGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIGEHQKTQGLR 12 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 176353460.0 38180900.0 65986490.0 72186070.0 True False 52297410.53002604 63070988.683657944 55137206.984778345 1.0 1.2060059579325895 1.0543008999101755 25.640236178408866 -10.406332918220023 5.276780213729793 0.9999041030259712 1.1301534289213855 0.4953085280978381 0.06193333059238234 6.992288198872047e-05 7.866688247265022e-06 0.060010791887053806 0.01998889649661972 3.923440599140134e-11 10.406332918220023 0.13024932589541427 GIGEHQK(ub)TQGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIGEHQKTQGLR 12 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 214067960.0 62680000.0 92595910.0 58792050.0 True False 52121197.194815025 92097077.45398082 71085195.83127426 1.0 1.7669793176420467 1.3638442640827475 25.63536688639821 -10.136036155030038 4.444712461627229 0.9999334473129701 1.56541179043852 0.7239714012564642 0.16457919674834834 24992005.247459613 28496784.943437662 16267.606462770951 0.05633983660990768 7.310782186639771e-11 10.136036155030038 0.56547834312555 GIGEHQK(ub)TQGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIGEHQKTQGLR 12 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 190489790.0 46125000.0 41955000.0 102409790.0 True False 59709721.75967873 39620167.36859095 83772259.03318164 1.0 0.6635463405449326 1.402991951132354 25.831462510150818 -6.782983969534692 1.524061723267613 0.81022757529834 1.4094252191639327 0.7778486815528463 0.1424755549502479 0.24597511067623773 1.1286397820311522 0.07361320886491607 0.17328148187785675 1.6482232288116395e-07 6.782983969534692 0.5991976438655927 GIGFLTSGWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIGFLTSGWR 10 0 Q8IXM3 Q8IXM3 MRPL41 39S ribosomal protein L41, mitochondrial 0 15811800.0 4557800.0 4576900.0 6677100.0 False True 5975319.937797985 3894044.3606164637 5986217.743265877 1.0 0.6516880102074485 1.0018238028392348 22.510584531006227 -10.968517191738211 10.428122273170906 1.0813489333443267 0.8267559065233416 0.24609347299466866 0.14294233877213638 0.08296908143740146 0.0002504859601783989 0.042475872753184575 0.04613444146103526 1.0751840379169446e-11 10.968517191738211 -0.25459302682098506 GIGFLTSGWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIGFLTSGWR 10 0 Q8IXM3 Q8IXM3 MRPL41 39S ribosomal protein L41, mitochondrial 0 13127100.0 4557800.0 3416900.0 5152400.0 False True 6242941.829913712 3265930.0598227074 3935509.237008905 1.0 0.52313959488997 0.6303933857194534 22.57379459252912 -9.77545868558381 6.173311912136401 1.000000011670906 0.576766490304211 0.9540487784304648 0.043786176753797874 7.011894868107562e-09 1.4326912858342259e-09 0.042395784603046244 0.01413192777985153 1.6770318641327222e-10 9.77545868558381 -0.423233521366695 GIGFLTSGWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIGFLTSGWR 10 0 Q8IXM3 Q8IXM3 MRPL41 39S ribosomal protein L41, mitochondrial 0 10888400.0 5622500.0 2532000.0 2733900.0 False True 4675357.868982893 2518359.613437351 3305545.8498746166 1.0 0.5386453152911717 0.7070145093713919 22.156645367703447 -10.648169244366898 10.50883586675901 1.0000757178526558 0.6228299123313071 0.869977094781436 0.06873643565002828 0.00012196493935180802 4.08330877858814e-06 0.06656690531394802 0.022184589212518115 2.248178321008805e-11 10.648169244366898 -0.3772458055213487 GIGIHHGGLLPILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIGIHHGGLLPILK 14 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 66869000.0 19703000.0 22057000.0 25109000.0 False True 25830823.804123413 18766181.577512614 22510961.54253534 1.0 0.7265034100274007 0.8714767176315097 24.62259031924977 -10.053301158671115 4.679185407818532 1.0000073238220344 0.7989900638237729 0.7193604531042959 0.05918510501257902 82014926.45888841 2.9337634239361967 6602.619340040559 0.02026063567426531 8.845020449547575e-11 10.053301158671115 -0.20101725999826148 GIGIHHGGLLPILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIGIHHGGLLPILK 14 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 77863000.0 22817000.0 18436000.0 36610000.0 False True 22092686.824394323 25797590.942469906 27020742.72354208 1.0 1.1676982137810734 1.2230627690655667 24.397065548387374 -13.999999999999998 0.15489348915016177 0.18239035419446664 1.2806762718485951 0.9995507334162613 0.0020101285070876804 11.979400502399637 0.1241786524158561 2.9444911293632328 0.052193148814285016 1.0000000000000041e-14 13.999999999999998 1.0982859176541284 GIGIHHGGLLPILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIGIHHGGLLPILK 14 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 79468000.0 19703000.0 28617000.0 31148000.0 False True 26987731.553554315 27352606.31623591 23791483.913196478 1.0 1.0135200234209214 0.8815666431980317 24.685800380772662 -6.88163944359669 1.0706493952400937 1.0085750121662613 0.8719175022229908 0.9749824561951166 0.009375370208561136 0.12618615596711844 0.2636140402095506 0.006735413081797421 0.01635746338212512 1.3132897552017324e-07 6.88163944359669 -0.13665750994327053 GIGIHHGGLLPILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIGIHHGGLLPILK 14 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 48571000.0 22817000.0 14542000.0 11212000.0 False True 18973346.464487776 14463659.359639017 13556377.361569256 1.0 0.7623146178619836 0.7144958527449331 24.17747082382165 -13.999999999999998 0.22542263714029379 2.469347834680678 0.6902096813637633 0.9995038942768266 0.0027808902391387685 13.15282946010103 0.15036601109384734 8.62813259423068 0.025548763672116052 1.0000000000000041e-14 13.999999999999998 -1.7791381533169146 GIGLAIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIGLAIAR 8 0 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 0 14952900.0 4480800.0 3649400.0 6822700.0 False True 5874372.192128927 3104923.745249781 6116752.451959687 1.0 0.5285541405445962 1.0412606235872364 22.486003245052956 -6.664962215869592 1.9552126661924285 0.6977775637254063 1.0391472358443656 0.2568457754438265 0.20049686661112007 0.47284843735403087 3.479889417819627 0.08269804994395057 0.22241168872788977 2.162906690965976e-07 6.664962215869592 0.3413696721189593 GIGLAIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIGLAIAR 8 0 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 0 7627500.0 2723700.0 1175800.0 3728000.0 False True 2637237.6343779997 1645303.0717159978 2751524.9623972923 1.0 0.6238736510765922 1.043335999202153 21.330596143747087 -6.670392718117215 1.9362979900398318 0.7599922381659682 1.041629996672044 0.280601623890148 0.15975754104196194 0.4602473718151094 3.327234204836056 0.06641841177462654 0.17734202099681845 2.1360296750296485e-07 6.670392718117215 0.28163775850607575 GIGLAIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIGLAIAR 8 0 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 0 16917900.0 4480800.0 3289700.0 9147400.0 False True 6137472.849066957 3144350.1764168628 6986972.516616581 1.0 0.5123200140746659 1.1384119634319472 22.549213306575847 -6.698843184933661 1.8350345914787896 0.6968271855421992 1.1365072436128785 0.41207487735532855 0.20589967845383236 0.3979316192262165 2.6043026157925615 0.08954311631859402 0.23060727535019762 2.0005841102103218e-07 6.698843184933661 0.4396800580706792 GIGLAIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIGLAIAR 8 0 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 0 7624600.0 2723700.0 2006700.0 2894200.0 False True 2264877.2303688196 1995889.5088012363 3499363.838731154 1.0 0.8812351866313829 1.5450567438312348 21.111001419181363 -6.8606454743135545 1.1825698582613926 0.9354570823363989 1.5775857109847449 0.9544148882421792 0.06171008501408756 0.14613199344593392 0.38797452551708594 0.04069166394718329 0.09505015153295737 1.378334179188256e-07 6.8606454743135545 0.642128628648346 GIGLAIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIGLAIVR 8 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 26823900.0 7122600.0 9113300.0 10588000.0 False True 9337797.575356513 7753631.163365166 9492455.327267675 1.0 0.830349030463871 1.016562551357862 23.15465088352061 -11.730389086133854 15.670547764759934 0.9315832952889674 0.9311102127231217 0.0 0.08602464921846836 0.0 0.0 0.0 0.025093615557240823 1.860419632549236e-12 11.730389086133854 -0.0004730825658457727 GIGLAIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIGLAIVR 8 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 14905500.0 6684300.0 2333600.0 5887600.0 False True 6472110.555300838 3265418.649563235 4345460.935786022 1.0 0.5045369082715633 0.6714132737159393 22.62580482113131 -10.278040425697009 5.526535691455408 1.000042168496526 0.5879750909937392 0.8904497432336844 0.06812699091153265 3.540027589030133e-05 4.624526512434532e-06 0.06597040723125805 0.02198789176895955 5.2718078724947753e-11 10.278040425697009 -0.4120670775027867 GIGLAIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIGLAIVR 8 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 20812900.0 7122600.0 6163900.0 7526400.0 False True 9756017.701027555 5891558.516708486 5748819.331073645 1.0 0.6038896911890551 0.5892588048982474 23.2178609450435 GIGLAIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIGLAIVR 8 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 15634500.0 6684300.0 4765300.0 4184900.0 False True 5558291.614698508 4739628.383062009 5059943.241208632 1.0 0.8527131556984879 0.9103414487696131 22.406210096565587 -10.839442222813652 9.722946484466313 1.0032547945310588 0.8815273024329752 0.8492869977788388 0.02352665212863733 0.0016965662300998695 2.8015815274565602e-05 0.023282675574203746 0.007593194323852307 1.4472973842277807e-11 10.839442222813652 -0.12172749209808365 GIGLAIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIGLAIVR 8 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 23083400.0 6434300.0 9848800.0 6800300.0 False True 8329328.189014642 9300705.622208996 5562715.176970327 1.0 1.1166213422200701 0.6678467999744402 22.989768707476507 -6.837699763352193 1.2930878634050977 1.0620694482496826 0.6537504869025386 0.9204177215043411 0.05363466392462877 0.171502802094979 0.5580454919627071 0.03253650185494892 0.07491579936621502 1.4531158390944834e-07 6.837699763352193 -0.40831896134714407 GIGMGNIGPAGMGMEGIGFGINK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIGMGNIGPAGMGMEGIGFGINK 23 0 P52272-2;P52272;A0A087X0X3;M0QYL3;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 6677000.0 2180600.0 2972500.0 1523900.0 False True 2858787.7169604376 2529014.5867142496 1366221.4462809998 1.0 0.8846458139267458 0.4779023773523184 21.446972064053934 -6.947774208769694 0.5827694257807027 1.0048132174892324 0.33752092345539914 0.9990148215622026 0.007028853099471411 0.08439205629300793 0.039757906670213956 0.007342521774381356 0.03400362005887033 1.1277836424688291e-07 6.947774208769694 -0.6672922940338333 down GIGMGNIGPAGMGMEGIGFGINK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIGMGNIGPAGMGMEGIGFGINK 23 0 P52272-2;P52272;A0A087X0X3;M0QYL3;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 20700100.0 8510500.0 3480600.0 8709000.0 False True 8240338.835912176 4870421.731089219 6427851.635600325 1.0 0.5910462940993956 0.7800470057841723 22.97427223037827 -10.072360890260706 4.7793427979346195 1.0000105163927817 0.6855466499378674 0.7868182132908715 0.07715921746024361 9.52843788512837e-06 1.8493673640854292e-06 0.07471184293938643 0.024903030349847602 8.465236770875363e-11 10.072360890260706 -0.3144638664549143 GIGMGNIGPAGMGMEGIGFGINK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GIGMGNIGPAGMGMEGIGFGINK 23 0 P52272-2;P52272;A0A087X0X3;M0QYL3;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 15180200.0 2599700.0 4198500.0 8382000.0 False True 3560879.3442508867 4012996.3874171423 6402344.232708774 1.0 1.1269678075153566 1.7979671911786315 21.76380212201478 -6.93857783231096 0.6726689667228853 0.9922509382548396 1.9715842534052699 0.9979715692958531 0.015767713989244966 0.08842153159927149 0.057610472193542595 0.015188060222400676 0.05812278896919445 1.1519195994570802e-07 6.93857783231096 0.9793333151504303 GIGMGNIGPAGMGMEGIGFGINK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIGMGNIGPAGMGMEGIGFGINK 23 0 P52272-2;P52272;A0A087X0X3;M0QYL3;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 14875900.0 8510500.0 2519000.0 3846400.0 False True 7076857.829075838 2505429.647017646 4650664.456255798 1.0 0.35403136639595717 0.6571651668835524 22.754677505812545 -10.506185951395487 6.310317272281071 1.000378404824215 0.5055982666398678 0.780062444638502 0.12375385583087453 0.0006593066177033091 5.1594172759272275e-05 0.11991222348847798 0.03994138522182757 3.117554458386401e-11 10.506185951395487 -0.4947801381843472 GIHFCHDLVSLCNFHNYDNLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIHFCHDLVSLCNFHNYDNLR 21 0 O94925-3;O94925;B8ZZC5;C9JIJ6;B8ZZA8;B7Z509;H7C201 O94925-3 GLS Glutaminase kidney isoform, mitochondrial 0 25374900.0 6589400.0 12371000.0 6414500.0 False True 9996601.549667794 10163298.39493582 5146671.26342478 1.0 1.0166753515622082 0.514842092870633 23.25300628813678 -6.8992145263894535 0.9662331265211989 1.0213164401270085 0.46300088334827233 0.9861710851151579 0.02736887378948671 0.11198531756689878 0.18070427391701252 0.021275450144992217 0.05513937033785485 1.261204389535061e-07 6.8992145263894535 -0.5583155567787361 GIHFCHDLVSLCNFHNYDNLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIHFCHDLVSLCNFHNYDNLR 21 0 O94925-3;O94925;B8ZZC5;C9JIJ6;B8ZZA8;B7Z509;H7C201 O94925-3 GLS Glutaminase kidney isoform, mitochondrial 0 21357800.0 3848900.0 5387900.0 12121000.0 False True 5271942.342611536 5149844.762597319 9258269.439830942 1.0 0.9768401146903032 1.7561401165181785 22.329903161505634 -6.900052514504274 0.9609530394134452 0.9676452911042689 1.8380228635699722 0.9865916269863038 0.04192111545128965 0.11136677893633658 0.177210542728888 0.032715845283458105 0.08514188040014704 1.2587731928511648e-07 6.900052514504274 0.8703775724657034 GIHFCHDLVSLCNFHNYDNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIHFCHDLVSLCNFHNYDNLR 21 0 O94925-3;O94925;B8ZZC5;C9JIJ6;B8ZZA8;B7Z509;H7C201 O94925-3 GLS Glutaminase kidney isoform, mitochondrial 0 26155600.0 6589400.0 11387000.0 8179200.0 False True 8530108.196492713 10753303.440022523 6690669.525679129 1.0 1.2606291962913099 0.7843592802761988 23.02413261022923 -6.75816921514088 1.6198598422259556 1.1517368534015102 0.7828050668946779 0.6832479272549006 0.10959283078955032 0.2860078938514788 1.478759660793841 0.05339726041003383 0.12852960587610535 1.7451420567902346e-07 6.75816921514088 -0.36893178650683234 GIHFSIVSPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIHFSIVSPR 10 0 M0QZQ2;Q71SY5-5;Q71SY5;Q71SY5-4;M0QYR4;B9TX33;A0A087WW16 M0QZQ2 MED25 Mediator of RNA polymerase II transcription subunit 25 0 12770100.0 3737700.0 3229200.0 5803200.0 False True 4900160.895938288 2747415.9473230154 5202740.532225138 1.0 0.5606787217130627 1.061748918599317 22.224397689972704 -6.675119265612447 1.9195113227423752 0.7208251434851302 1.0597638590279645 0.3018455657192638 0.18639701174026063 0.4494363477657311 3.1972968769680623 0.07804771814143958 0.20712033278694747 2.1129087148100928e-07 6.675119265612447 0.3389387155428344 GIHFSIVSPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIHFSIVSPR 10 0 M0QZQ2;Q71SY5-5;Q71SY5;Q71SY5-4;M0QYR4;B9TX33;A0A087WW16 M0QZQ2 MED25 Mediator of RNA polymerase II transcription subunit 25 0 9464700.0 3406900.0 1784300.0 4273500.0 False True 3298749.8243427733 2496780.2950015794 3154142.147748073 1.0 0.7568868292396274 0.9561628846396343 21.653487938052734 -10.00488343775561 5.954008630787724 1.000000170546946 0.8565248570965462 0.40869169375269465 0.0813541089475026 1.8419333275788755e-07 3.0753986777993324e-08 0.07877087176340894 0.026256925758258547 9.88818452465689e-11 10.00488343775561 -0.14347531345039966 GIHFSIVSPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIHFSIVSPR 10 0 M0QZQ2;Q71SY5-5;Q71SY5;Q71SY5-4;M0QYR4;B9TX33;A0A087WW16 M0QZQ2 MED25 Mediator of RNA polymerase II transcription subunit 25 0 15413500.0 4599800.0 5229300.0 5584400.0 False True 6978232.890424317 4296090.558292612 4480640.892270527 1.0 0.6156416138228636 0.6420881851648946 22.734430315932634 -10.722127839950279 6.802056760997564 1.004780021191884 0.6288648994938927 0.9962061052520886 0.010796767539014743 0.0007883079249108805 3.220330423464701e-05 0.010529545004419601 0.003484641739289747 1.8961476845387078e-11 10.722127839950279 -0.37591512169799135 GIHFSIVSPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIHFSIVSPR 10 0 M0QZQ2;Q71SY5-5;Q71SY5;Q71SY5-4;M0QYR4;B9TX33;A0A087WW16 M0QZQ2 MED25 Mediator of RNA polymerase II transcription subunit 25 0 13249300.0 3737700.0 4105400.0 5406200.0 False True 5119628.697544536 3924009.85325768 4129366.904183982 1.0 0.7664637584244546 0.8065754663349901 22.287607751495596 -10.201675393728369 5.339135195729737 1.0000116679612934 0.7865196123796929 0.9742048563671717 0.01637553618221514 2.2745146198158293e-06 3.400675453728296e-07 0.015856411059785712 0.005285181576555881 6.28527966187978e-11 10.201675393728369 -0.21349205558160045 GIHFSIVSPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIHFSIVSPR 10 0 M0QZQ2;Q71SY5-5;Q71SY5;Q71SY5-4;M0QYR4;B9TX33;A0A087WW16 M0QZQ2 MED25 Mediator of RNA polymerase II transcription subunit 25 0 7225600.0 3406900.0 1419600.0 2399100.0 False True 2832988.301260614 1411952.3330314616 2900740.717814914 1.0 0.4983968103232815 1.0239155299455884 21.43389321348701 -10.987587140218482 12.808747056432965 1.1656230756465276 0.761156170134435 0.2159425765250611 0.21454211889256494 0.06975924847758717 6.760314136980357e-05 0.014280993468443954 0.0692431711275796 1.0289940411219213e-11 10.987587140218482 -0.4044669055120925 GIHFSIVSPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIHFSIVSPR 10 0 M0QZQ2;Q71SY5-5;Q71SY5;Q71SY5-4;M0QYR4;B9TX33;A0A087WW16 M0QZQ2 MED25 Mediator of RNA polymerase II transcription subunit 25 0 20098600.0 4599800.0 9537000.0 5961800.0 False True 5954531.775613447 9006257.56630322 4876813.57323379 1.0 1.5125047452409268 0.8190087410745862 22.505556638025084 -6.708761508394837 1.79980512831847 1.3154837664125458 0.8207122329402674 0.4590836254168523 0.21601015601186369 0.3775964385685058 2.3835832742486187 0.09554139084866055 0.24306840358607434 1.9554129705762625e-07 6.708761508394837 -0.4947715334722784 GIIASSVGTILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIIASSVGTILK 12 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9 A0A3B3IRI2 CTPS1 CTP synthase 1 0 21431200.0 6680400.0 8440700.0 6310100.0 False True 8758069.09308563 7181380.461590906 5657191.382753292 1.0 0.8199730311856643 0.6459404832989458 23.062181400692587 -6.971538865685534 0.2183241374589607 1.0819739563775859 0.37903489860851436 0.9999920245991452 0.00040818234412335084 0.07580644325847076 0.0072162916039163975 0.00488300166933614 0.017702269074994007 1.0677292355211095e-07 6.971538865685534 -0.7029390577690715 GIIASSVGTILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIIASSVGTILK 12 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9 A0A3B3IRI2 CTPS1 CTP synthase 1 0 40849100.0 12281000.0 8382100.0 20186000.0 False True 11891146.377279533 11729116.242074043 14898681.03298059 1.0 0.9863738843956137 1.2529221792650342 23.50338447038779 -6.894856757818836 0.9932207802978831 0.9873005506158373 1.2781527307414173 0.983828780012852 0.01558632557227834 0.11529047533566887 0.19954233083025893 0.011874239638201133 0.030169642472313452 1.273923186390774e-07 6.894856757818836 0.29085218012558 GIIASSVGTILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIIASSVGTILK 12 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9 A0A3B3IRI2 CTPS1 CTP synthase 1 0 42222400.0 6680400.0 11933000.0 23609000.0 False True 9150324.411021894 11405760.602845963 18033040.442617662 1.0 1.2464870195320414 1.9707542194784065 23.12539146221548 -6.951916729440035 0.5373923825435044 0.9891501519743472 2.2613885174836827 0.9993432252573773 0.010558530174591409 0.08272515355019013 0.03284722344225166 0.011655223903660021 0.05995522924337884 1.1170774129345375e-07 6.951916729440035 1.2722383655093354 GIIASSVGTILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIIASSVGTILK 12 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9 A0A3B3IRI2 CTPS1 CTP synthase 1 0 22730200.0 12281000.0 4560800.0 5888400.0 False True 10212195.640547607 4536230.065152076 7119637.215114554 1.0 0.4441973327597581 0.6971700764178446 23.283789745822066 -10.390194599840939 5.986014565237197 1.0000960446914864 0.5706837045888058 0.7933940141094631 0.1032756901323677 0.00013240584729992875 1.3488458578197385e-05 0.10001845031709523 0.033332085662561364 4.0719777864263375e-11 10.390194599840939 -0.4294123401026806 GIIDPTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIIDPTK 7 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 17318080.0 514880.0 9847000.0 6956200.0 False True 675012.6661050131 8377865.983305378 6236439.152582119 1.0 12.411420413260831 9.238995748876665 19.364555047941682 -9.459816317686656 9.066327084785154 0.9999963235741555 10.825208081184794 0.9274788936987615 1.2951369458622033 0.0 0.0 1.2540109555946717 0.41800365186489047 3.4688353179411386e-10 9.459816317686656 9.825211757610639 GIIDPTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIIDPTK 7 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 21411880.0 514880.0 10469000.0 10428000.0 False True 705245.0501088188 10006444.963646578 7965121.171401464 1.0 14.188607154495577 11.294118505578242 19.427765109464573 -9.99874258614412 11.147316532324071 0.9999993588633087 12.741362829971552 0.9564075821465576 1.1816700426876166 0.0 0.0 1.1441470990103102 0.38138236633677 1.0028994978363097e-10 9.99874258614412 11.741363471108244 GIITWGLLPGPYHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIITWGLLPGPYHR 14 0 A0A3B3IUD2;Q9BUK6-7;Q9BUK6-3;Q9BUK6-2;Q9BUK6;Q9BUK6-5 A0A3B3IUD2 MSTO1 Protein misato homolog 1 0 11254900.0 1099100.0 4482000.0 5673800.0 False True 1505466.9720606788 4283970.42000801 4333765.295578986 1.0 2.8456090366061795 2.878685069820523 20.521779626927152 -10.630918243820075 0.7379646615223288 3.800834239337352e-18 2.8723919075731716 0.9999622762692162 0.005392202122702007 2.1626437790332655 0.38130206288765267 4.000405296878914 0.004988904090318841 2.3392775675267635e-11 10.630918243820075 2.8723919075731716 GIITWGLLPGPYHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIITWGLLPGPYHR 14 0 A0A3B3IUD2;Q9BUK6-7;Q9BUK6-3;Q9BUK6-2;Q9BUK6;Q9BUK6-5 A0A3B3IUD2 MSTO1 Protein misato homolog 1 0 8498300.0 3709000.0 2494500.0 2294800.0 False True 3084197.8365598097 2481061.63338052 2774632.0700436225 1.0 0.8044430885626835 0.8996284340626202 21.556463879541276 -10.101680440400392 4.5148852030362745 1.0000126760824237 0.8520357613072257 0.7631398253030872 0.03885925459764617 54107799.47897363 0.19700478057321383 7319.271152251992 0.013302556441355787 7.912606338453703e-11 10.101680440400392 -0.14797691477519803 GIITWGLLPGPYHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIITWGLLPGPYHR 14 0 A0A3B3IUD2;Q9BUK6-7;Q9BUK6-3;Q9BUK6-2;Q9BUK6;Q9BUK6-5 A0A3B3IUD2 MSTO1 Protein misato homolog 1 0 10278900.0 2417300.0 7861600.0 0.0 False True 3129242.5021066954 7424095.049098197 0.0 1.0 2.3724895223365032 0.0 21.577382034560163 -6.751933086698877 1.6561680882614032 1.8071090589378163 9.721598671143926e-10 0.6482347224555917 0.576809107294002 0.29867836278544524 1.614772849864643 0.27571087238775965 0.6644826121129502 1.7703817063344592e-07 6.751933086698877 -1.8071090579656564 GIK(ub)LVVADTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIKLVVADTR 10 1 P22314-2;P22314;Q5JRR9;Q5JRS0 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 4395900.0 1016700.0 1889300.0 1489900.0 True False 1332903.5457368058 1607423.8044337214 1335739.4401299707 1.0 1.2059565822110299 1.0021276066090719 20.346140954310748 -11.100391630299432 2.472973887574209 0.8157309395659723 1.1040420942745455 0.257827755704796 0.0832128333931208 4660128.782177979 2889619.952806854 4804999.422255749 0.032460225998411606 7.936122625024582e-12 11.100391630299432 0.28831115470857316 GIK(ub)LVVADTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIKLVVADTR 10 1 P22314-2;P22314;Q5JRR9;Q5JRS0 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 6795000.0 2058600.0 2100000.0 2636400.0 True False 1993250.8698206705 2938540.9513553283 1945847.7496953367 1.0 1.474245412781234 0.9762181866602679 20.92669186799544 -8.805742105915092 18.635493035818026 1.0000826570544128 1.2252317988107395 0.21427148615698066 0.20331876926890013 0.0 0.0 0.19686254930685937 0.0656208497689531 1.564076151439227e-09 8.805742105915092 0.22514914175632672 GIK(ub)LVVADTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIKLVVADTR 10 1 P22314-2;P22314;Q5JRR9;Q5JRS0 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 2706100.0 1016700.0 0.0 1689400.0 True False 1392601.4652844076 0.0 1290398.514285158 1.0 0.0 0.9266100506519451 20.40935101583364 -10.020646655600258 14.109035646475471 0.9999908110329021 0.46330502594390727 0.30905868034451656 0.37828696914249166 0.0 0.0 0.36627478287722787 0.12209159429240926 9.535716797075274e-11 10.020646655600258 -0.5366857850889948 GIK(ub)LVVADTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIKLVVADTR 10 1 P22314-2;P22314;Q5JRR9;Q5JRS0 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 5541900.0 2058600.0 2219400.0 1263900.0 True False 1711817.1114429857 2207443.651683593 1528175.6463866723 1.0 1.2895324137885362 0.8927213287980794 20.707097143429717 -6.711085963607648 1.7912539561714402 1.177804419623997 0.8936223545589325 0.4702115238726273 0.12198762001419314 0.37294090750822306 2.3332453321784006 0.05417994506790658 0.13746568600309647 1.94497505803106e-07 6.711085963607648 -0.2841820650650645 GIK(ub)LVVADTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIKLVVADTR 10 1 P22314-2;P22314;Q5JRR9;Q5JRS0 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 6427300.0 1971800.0 1734000.0 2721500.0 True False 2552533.969988819 1637501.3756914956 2226214.9249481284 1.0 0.6415199150899716 0.8721587846127195 21.2834987304305 -10.67060001961794 6.149406495121945 1.0022923393896108 0.7568393498513456 0.5971058282925201 0.09415792419717975 0.0029839346902227363 0.00015983759533612905 0.09193079679391077 0.030389339360761453 2.1350103286845913e-11 10.67060001961794 -0.24545298953826522 GIK(ub)TCNCETEDYGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIKTCNCETEDYGEK 15 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 12441600.0 5158300.0 3783000.0 3500300.0 True False 7825518.222243521 3107894.0932860957 2808464.170764006 1.0 0.39714866223838197 0.35888539148514553 22.899754862826967 -13.918188241621221 0.39254791427286206 9.999847418384132 0.35620949542203695 0.9998254802595552 0.00387890825515613 24.020020191529806 0.2054357547295066 183.1419537612511 0.01000160071225401 1.207290430879609e-14 13.918188241621221 -9.643637922962094 GIK(ub)TCNCETEDYGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIKTCNCETEDYGEK 15 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 14283800.0 6162500.0 3659500.0 4461800.0 True False 8440942.785300644 3497811.189651788 3408014.733655456 1.0 0.41438631662602904 0.40374811443933645 23.008972714668488 GILAADESTGSIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GILAADESTGSIAK 14 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 241938000.0 20832000.0 126070000.0 95036000.0 False True 27310953.737374954 107260847.41701105 85202586.36968371 1.0 3.92739295919296 3.1197221154925923 24.702976360158594 -10.522896540741119 11.342200612954738 0.9999902217054248 3.523557537342773 0.9286558373435294 0.32973024119818106 8.159645694734418e-05 3.432702680369106e-06 0.3192611587633147 0.10641997774179249 2.9998770758303074e-11 10.522896540741119 2.523567315637348 GILAADESTGSIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GILAADESTGSIAK 14 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 171812000.0 47307000.0 15685000.0 108820000.0 False True 45805265.17954264 21948102.29619442 80316777.46997668 1.0 0.4791611228570464 1.7534398535879983 25.44901010558675 -6.795745122709628 1.4733511854938823 0.7110578376304979 1.769209641578227 0.8193768206291763 0.22231766780932832 0.2268987940653579 0.9728034629975448 0.11873521445167808 0.2768648943194992 1.600497047388091e-07 6.795745122709628 1.0581518039477291 GILAADESTGSIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GILAADESTGSIAK 14 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 537497600.0 6097800.0 521940000.0 9459800.0 False True 9250808.408893729 428795729.0641664 7590066.383622371 1.0 46.352244053819355 0.820476011191117 23.141148014579155 -6.240742659584594 22.938259308943543 9.999999999999998 0.8204505378105627 0.0 21.621637678865813 1768.2725266737823 4380978.8476352235 9.244616214751249 73.72992353801133 5.744567546959845e-07 6.240742659584594 -9.179549462189435 GILAADESTGSIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GILAADESTGSIAK 14 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 212769000.0 20832000.0 112780000.0 79157000.0 False True 28534153.3636321 107797006.68641329 60461746.88958823 1.0 3.777823905012188 2.118925559804732 24.766186421681486 -10.180412188537113 6.041015634494883 0.9999781963489087 2.948374732408475 0.647796098877518 0.6772424134843287 0.0001988796086527245 2.698346621345306e-05 0.6557444240559229 0.2185790490641691 6.600666818758199e-11 10.180412188537113 1.9483965360595663 GILAADESTGSIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GILAADESTGSIAK 14 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 69015800.0 47307000.0 11925000.0 9783800.0 False True 39337866.555442214 11860757.658072842 11829547.34481996 1.0 0.3015099367769847 0.30071654567609984 25.229415381021028 GILAADESTGSIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GILAADESTGSIAK 14 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 39669800.0 6097800.0 19980000.0 13592000.0 False True 7893722.305607994 18868095.436168432 11118395.465697221 1.0 2.3902659234368855 1.4085110972042048 22.912274336671604 -10.222906344686715 5.97453727259708 0.9999795290743272 1.899388510320547 0.5280776934533236 0.40079972946415804 0.00010929923165242357 1.4216140964807654e-05 0.3880814684869815 0.1293575564482574 5.985406560342676e-11 10.222906344686715 0.8994089812462198 GILAADESTGSIAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 GILAADESTGSIAKR 15 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 82935900.0 23392100.0 38893000.0 20650800.0 True False 30667269.629418653 33090316.003726587 18514053.312461246 1.0 1.0790108282735267 0.6037072597653426 24.870196390404175 -6.864184025844608 1.1643277017182716 1.043449259576176 0.5787720625636082 0.9585310847432839 0.04234759964747667 0.1425584509814561 0.36487332679319245 0.028313977136871334 0.06644066342526614 1.3671493935657144e-07 6.864184025844608 -0.4646771970125677 GILAADESTGSIAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 GILAADESTGSIAKR 15 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 171192900.0 57358000.0 35179900.0 78655000.0 True False 55537201.68618186 49227417.53075495 58052895.90057904 1.0 0.8863863507009062 1.0452974607653507 25.726951151141897 -6.71474471452322 1.7780015918270309 0.9304951100069467 1.0449836259504854 0.48772499633149435 0.04784226572766221 0.3656228706398316 2.2558419907926814 0.021388689433583605 0.05403289159300607 1.9286582772756814e-07 6.71474471452322 0.1144885159435387 GILAADESTGSIAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 GILAADESTGSIAKR 15 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 231454000.0 83175000.0 73876000.0 74403000.0 True False 126182555.9070052 60692250.60417742 59697214.438006595 1.0 0.4809876465722153 0.4731019593706963 26.910937237993476 GILAADESTGSIAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GILAADESTGSIAKR 15 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 86441300.0 23392100.0 33486900.0 29562300.0 True False 32040791.517733257 32007338.031630136 22580293.59467986 1.0 0.9989559094979097 0.704735823463743 24.933406451927066 -6.9076781969882255 0.9114041253483159 1.009791971692444 0.6685427215673946 0.9900154142690462 0.013883628822427491 0.10597335302336394 0.14724503934329922 0.011237806410269063 0.030544253376631355 1.2368635836946448e-07 6.9076781969882255 -0.34124925012504936 GILAADESTGSIAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GILAADESTGSIAKR 15 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 159768100.0 57358000.0 59989000.0 42421100.0 True False 47695718.39023936 59665827.35011576 51291155.8769947 1.0 1.2509682077107789 1.0753828143930657 25.507356426576173 -10.50845253731519 4.177691005201285 0.9985574823972847 1.16317551105233 0.5352125681518092 0.0716824366546091 0.0009714305997462736 0.00011429853111978437 0.0700064240026105 0.023135406947931172 3.101326304258733e-11 10.50845253731519 0.16461802865504538 GILAADESTGSIAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GILAADESTGSIAKR 15 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 378244000.0 83175000.0 104934000.0 190135000.0 True False 107671677.12436377 99094330.65560065 155532380.94984832 1.0 0.9203379505377627 1.4445059750504687 26.682063560085926 -6.868153158276002 1.1437503827351914 0.9554075571350494 1.4741544213323436 0.9628086633187041 0.04447582011767405 0.13864174025683335 0.3401149048224872 0.030209927334723802 0.07130641555780314 1.354711575564665e-07 6.868153158276002 0.5187468641972942 GILDTLK(ub)TQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GILDTLKTQLR 11 1 O75665;O75665-3;O75665-2 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 14778800.0 2301200.0 3606600.0 8871000.0 True False 2228149.665613196 5046734.188170542 6547418.975704488 1.0 2.2649888676942447 2.938500531068505 21.087414711600868 -9.064504498310978 0.21093713065302783 6.303384251592184e-20 3.5771234958637144 0.9994795730313827 0.01833185631993778 0.5236380588255594 0.07229737097987246 0.7093476670564168 0.34674263958962515 8.619766505262121e-10 9.064504498310978 3.5771234958637144 GILDTLK(ub)TQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GILDTLKTQLR 11 1 O75665;O75665-3;O75665-2 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 15844200.0 2301200.0 3836600.0 9706400.0 True False 1913549.7604452525 3815931.474294528 11735963.362677122 1.0 1.9941637020228946 6.133085015749133 20.867819987035144 -6.94395656259063 0.6216650843448986 0.9547484363141678 7.392400473609286 0.9986375660532675 0.08204616436191271 0.08600707241973753 0.046731721130913194 0.0825016567359647 0.35049948069634046 1.1377410750966045e-07 6.94395656259063 6.437652037295118 GILDTLK(ub)TQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GILDTLKTQLR 11 1 O75665;O75665-3;O75665-2 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 21765400.0 1792500.0 3830900.0 16142000.0 True False 2320426.585457429 3617707.047368251 13204321.630906729 1.0 1.5590698150250193 5.690471620029187 21.1459586230176 -6.93160347491981 0.7335107903002549 0.9407615465304232 6.574331621731365 0.9968440984909062 0.11751327906223796 0.09181380514443631 0.07366377478449818 0.10809989085774993 0.3705797011864476 1.1705676698642629e-07 6.93160347491981 5.633570075200942 up GILEGAGAGAAGGSDAEVTAADWKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 GILEGAGAGAAGGSDAEVTAADWKK 25 1 Q9C0B7 Q9C0B7 TANGO6 Transport and Golgi organization protein 6 homolog 1 13079400.0 4530500.0 4949200.0 3599700.0 True False 4386681.7573703155 6925441.369737049 2656830.5813147877 1.0 1.5787426015350254 0.6056583833214922 22.064698615613505 -6.745565941097618 1.6660505899225768 1.342104058725857 0.6043343973171884 0.629782253884855 0.2431572927604277 0.3078311837909692 1.6796474097975995 0.11535903535168177 0.2813992015301624 1.7965282836129022e-07 6.745565941097618 -0.7377696614086686 GILEGAGAGAAGGSDAEVTAADWKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 GILEGAGAGAAGGSDAEVTAADWKK 25 1 Q9C0B7 Q9C0B7 TANGO6 Transport and Golgi organization protein 6 homolog 1 29262300.0 11716000.0 8321000.0 9225300.0 True False 17774028.55433088 6836052.537730263 7401915.411407362 1.0 0.3846090669222294 0.41644556768779273 24.08326737521525 -9.97276631087888 5.283075335378206 1.000001885194141 0.40052731732099883 0.9978891590362755 0.01299719702278975 35732805.98876493 36.27612427564396 974.9848323637626 0.004449286244390156 1.0647157760526441e-10 9.97276631087888 -0.5994745678731421 GILEGAGAGAAGGSDAEVTAADWKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GILEGAGAGAAGGSDAEVTAADWKK 25 1 Q9C0B7 Q9C0B7 TANGO6 Transport and Golgi organization protein 6 homolog 1 12824000.0 4182200.0 4264700.0 4377100.0 True False 5728472.359705368 4076271.452523017 3343319.129204197 1.0 0.7115808886843736 0.5836318863509631 22.449719028914338 -13.999999999834303 0.11014219830772037 2.3913070435664223 0.34939401964105504 0.9997423396202205 0.0027952359678261583 12.011765573946187 0.10073115418056464 3.71542870571384 0.20804366275236894 1.000000000381531e-14 13.999999999834303 -2.041913023925367 GILEGAGAGAAGGSDAEVTAADWKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GILEGAGAGAAGGSDAEVTAADWKK 25 1 Q9C0B7 Q9C0B7 TANGO6 Transport and Golgi organization protein 6 homolog 1 15261200.0 4530500.0 7230300.0 3500400.0 True False 3767311.4851804296 7191348.938797821 4232317.4559790455 1.0 1.9088809001025309 1.123431782221306 21.84510389104778 -10.203733450033925 4.3503806714029025 0.9998342371288074 1.516156341179606 0.36539822845295766 0.32065825974509 225498326.26842663 130.05162055746118 400493.6004317378 0.10976985130132016 6.255565127765564e-11 10.203733450033925 0.5163221040507986 GILFVGSGVSGGEEGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GILFVGSGVSGGEEGAR 17 0 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 100244000.0 27687000.0 37416000.0 35141000.0 False True 36297925.12128939 31833678.646425657 31504946.41627445 1.0 0.8770109734937612 0.8679544715297303 25.113383746791236 -13.999999999999892 0.37016357983192827 2.714902686521857 0.8670179903782602 0.9997911722000844 0.0008702966466030211 22.83908583237708 0.1974969121668617 31.081448536926295 0.0025298008469973204 1.0000000000002494e-14 13.999999999999892 -1.8478846961435968 GILFVGSGVSGGEEGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GILFVGSGVSGGEEGAR 17 0 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 74440000.0 22347000.0 12590000.0 39503000.0 False True 21637606.717129372 17617252.65598265 29155979.235402364 1.0 0.8141959915574205 1.347467842287802 24.367037599223146 -6.8125974701402665 1.40365032115138 0.8990441581755163 1.3573556849865769 0.8664779904156396 0.08076101114760094 0.20328594524463237 0.7888944027809155 0.04523530553083988 0.10451775445524662 1.5395809540602075e-07 6.8125974701402665 0.4583115268110606 GILFVGSGVSGGEEGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GILFVGSGVSGGEEGAR 17 0 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 109652000.0 27687000.0 35579000.0 46386000.0 False True 37923632.11304158 34007002.135980606 35430582.149657466 1.0 0.8967232367040582 0.9342613082008361 25.176593808314127 -10.189219563344915 6.773825408293128 1.000000272151942 0.9154922727563299 0.8710928927414213 0.01532485351586989 6.298486239934921e-08 7.540199902823484e-09 0.014838273371453324 0.004946075204169352 6.46815526890947e-11 10.189219563344915 -0.08450799939561215 GILFVGSGVSGGEEGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GILFVGSGVSGGEEGAR 17 0 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 76577000.0 15243000.0 41394000.0 19940000.0 False True 19732363.98445056 39090387.51174961 16311124.601677626 1.0 1.9810291125054 0.8266178656815306 24.234060468947202 -6.6816040791320574 1.8966874807455807 1.6198258614543193 0.8310068122836443 0.3313063790903569 0.4156400021687418 0.4349421342988815 3.0266431701040144 0.17577206967515152 0.46255186586467284 2.0815934893576647e-07 6.6816040791320574 -0.788819049170675 GILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVK 38 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 950152000.0 95600000.0 641981600.0 212570400.0 False True 145032189.29617894 527414967.65486574 170555767.2670837 1.0 3.636537310884827 1.1759856077107238 27.111797895091357 -6.629844669421374 2.0810174187784867 2.737181512109087 1.185871800690084 0.11695016117526336 1.1309769832597958 0.5593920792669401 4.616331880308788 0.4445338059300282 1.2528824208273759 2.3450674065501585e-07 6.629844669421374 -1.5513097114190029 GILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GILGYTEHQVVSSDFNSDTHSSTFDAGAGIALNDHFVK 38 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 325906000.0 95600000.0 69231000.0 161075000.0 False True 123756084.55772963 65378233.991059944 131761002.76906852 1.0 0.5282829868503343 1.0646830274240355 26.882924217183806 -6.674440848201637 1.9213563524959252 0.7000683785183031 1.062576009848826 0.29899127422437066 0.20017131583669265 0.45099619750222736 3.2137813006836478 0.0837423264279656 0.22247325207081986 2.1162118980098287e-07 6.674440848201637 0.3625076313305229 GILHAEMPCSEEPAHGLQLWVNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GILHAEMPCSEEPAHGLQLWVNLR 24 0 O00625 O00625 PIR Pirin 0 44954700.0 9892700.0 17952000.0 17110000.0 False True 12806295.164270408 16952955.418923713 13996155.563425487 1.0 1.3237985851069947 1.092912148587266 23.61034983144447 -10.196672323591699 4.432308360218049 0.9999426928626494 1.2083553668517393 0.5205684746477639 0.09425899301608665 5.339281031653325e-05 9.677076451636914e-06 0.0912909480526545 0.03042195917961265 6.358104717114002e-11 10.196672323591699 0.2084126739890899 GILLFGPPGTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GILLFGPPGTGK 12 0 O75351;I3L4J1;Q6PIW4;Q6PIW4-2;Q9UN37 O75351;I3L4J1;Q6PIW4;Q9UN37 VPS4B;FIGNL1;VPS4A Vacuolar protein sorting-associated protein 4B;Fidgetin-like protein 1;Vacuolar protein sorting-associated protein 4A 0 9493600.0 2184500.0 2775400.0 4533700.0 False True 2863900.65472809 2361321.1384244673 4064596.2143212594 1.0 0.8245122380645779 1.4192518192315466 21.449550017437176 -6.827695672535618 1.3383381592655255 0.9060733912046883 1.4344972176020796 0.9011535913931954 0.07844458980785118 0.18367424323311698 0.6442471374855395 0.04603343323810915 0.1059420902220443 1.486977261564406e-07 6.827695672535618 0.5284238263973913 GILLFGPPGTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GILLFGPPGTGK 12 0 O75351;I3L4J1;Q6PIW4;Q6PIW4-2;Q9UN37 O75351;I3L4J1;Q6PIW4;Q9UN37 VPS4B;FIGNL1;VPS4A Vacuolar protein sorting-associated protein 4B;Fidgetin-like protein 1;Vacuolar protein sorting-associated protein 4A 0 1190700.0 0.0 1190700.0 0.0 False True 0.0 1666152.7194184703 0.0 0.0 GILLFGPPGTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GILLFGPPGTGK 12 0 O75351;I3L4J1;Q6PIW4;Q6PIW4-2;Q9UN37 O75351;I3L4J1;Q6PIW4;Q9UN37 VPS4B;FIGNL1;VPS4A Vacuolar protein sorting-associated protein 4B;Fidgetin-like protein 1;Vacuolar protein sorting-associated protein 4A 0 12656500.0 2184500.0 5300800.0 5171200.0 False True 2992168.683892776 5066593.128598497 3949869.0642070617 1.0 1.693284591832209 1.3200689805590535 21.512760078960067 -10.182684909860436 4.695664241881527 0.9999264000419428 1.5066767861990042 0.7107678205355961 0.15236463528834773 0.00011741943376037882 2.0437294668267852e-05 0.14754775553979818 0.049175474583577995 6.566214867691238e-11 10.182684909860436 0.5067503861570615 GILLFGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GILLFGTK 8 0 P49748-2;P49748;P49748-3;K7EQP4;J3QKU9 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 30417700.0 8990700.0 7239000.0 14188000.0 False True 11786894.766062647 6158969.417400997 12719961.860906102 1.0 0.5225268859729008 1.079161400297726 23.4906803574519 -6.679603723116678 1.902929242235 0.6978001058399663 1.077056164135787 0.322501269241533 0.2023801878862897 0.439387352700567 3.0757597454606813 0.0853415099370901 0.22522703194301252 2.0912034026246314e-07 6.679603723116678 0.37925605829582065 GILLFGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GILLFGTK 8 0 P49748-2;P49748;P49748-3;K7EQP4;J3QKU9 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 21274600.0 6889200.0 2856400.0 11529000.0 False True 6670506.116957419 3996975.415929222 8509209.03741372 1.0 0.5992012218935406 1.2756466883048116 22.669364797709054 -6.746170832763863 1.6638022503606917 0.7632412378974883 1.2766225184895967 0.6323536145114796 0.16839762342632086 0.3068058259139682 1.6697373846198778 0.07999152884864778 0.19500125610264057 1.7940277946724098e-07 6.746170832763863 0.5133812805921084 GILLFGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GILLFGTK 8 0 P49748-2;P49748;P49748-3;K7EQP4;J3QKU9 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 25976000.0 8990700.0 6665300.0 10320000.0 False True 12314804.754531836 6370805.006800413 7882628.54707165 1.0 0.5173289494870768 0.6400936680844128 23.55389041897479 -10.13060489458797 7.7205130862121205 1.000000081734143 0.578711308785767 0.9401264403677656 0.05011848649663966 7.052213226779863e-08 7.961165052826618e-09 0.04852702528496464 0.016175671961550564 7.402784473548433e-11 10.13060489458797 -0.42128877294837597 GILLFGTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GILLFGTK 8 0 P49748-2;P49748;P49748-3;K7EQP4;J3QKU9 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 15049700.0 6889200.0 4254700.0 3905800.0 False True 5728675.0433075875 4231779.086608175 4722484.721621224 1.0 0.7387011926172821 0.8243589810768153 22.44977007314333 -10.53640285776813 8.893401812355405 1.0000164602327197 0.7815300868470487 0.8966234976307301 0.034969645703519646 1.1413782555514051e-05 5.950110424904241e-07 0.03386176137595153 0.011286404619375435 2.9080183471721413e-11 10.53640285776813 -0.218486373385671 GILLFGTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GILLFGTK 8 0 P49748-2;P49748;P49748-3;K7EQP4;J3QKU9 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 14949400.0 3489100.0 6162300.0 5298000.0 False True 4516708.730443247 5819362.58790294 4333818.362070615 1.0 1.2884077622007424 0.9595080446210922 22.106840450845016 -6.67505366348139 1.9192825843471675 1.1832807694110044 0.9607983252549795 0.3017105980382727 0.12236803654629311 0.4496093209081566 3.197572518293572 0.05123923793999963 0.13601139213974317 2.113227903263216e-07 6.67505366348139 -0.2224824441560248 GILLQLFGGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GILLQLFGGTR 11 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 111289000.0 33922000.0 53573400.0 23793600.0 False True 44472070.501115255 45580457.547477566 21331666.51632756 1.0 1.0249232166137736 0.47966434384458473 25.40639623850191 -6.89619059743889 0.9850497326497019 1.0250996065891362 0.4266615738003694 0.9845734777087413 0.03122092848558891 0.11426344437478136 0.19366091321239903 0.023931480545850342 0.06115605532266518 1.2700166147304284e-07 6.89619059743889 -0.5984380327887668 down GILLQLFGGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GILLQLFGGTR 11 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 464594300.0 247382100.0 95976000.0 121236200.0 False True 239529090.64561516 134299717.3082282 89480802.21196085 1.0 0.5606822826665572 0.373569665257688 27.835625640035357 -13.999999999986702 0.11662519908753104 3.100207475817684 0.0608802589208647 0.9997096494076173 0.004473884728019235 11.977942835835519 0.10465016911393113 5.858274915809294 0.27746527372974644 1.0000000000306193e-14 13.999999999986702 -3.0393272168968193 GILLQLFGGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GILLQLFGGTR 11 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 2252300000.0 655240000.0 853700000.0 743360000.0 False True 994046984.4605479 701350565.0114566 596434570.1737382 1.0 0.7055507194079638 0.6000064177020897 29.88873880268351 -13.999999999999998 0.14284095178237766 2.4104632773171524 0.4737547053652167 0.9995918536684847 0.0034194548944723193 11.937946413941265 0.11861216240136528 4.686344311880985 0.1130963976274629 1.0000000000000041e-14 13.999999999999998 -1.9367085719519357 GILLQLFGGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GILLQLFGGTR 11 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 480568710.0 33922000.0 159670000.0 286976710.0 False True 46463880.10758103 152615251.44191888 219198721.5688666 1.0 3.2845998028696326 4.7176155125517 25.4696063000248 -8.379857739319766 0.2571957710866441 1.7003620541873032e-16 5.81536712859723 0.9993114976198593 0.04017045670483308 0.12310607038349954 0.0648479701836992 0.5581418268034373 0.5223901915020019 4.170059586253045e-09 8.379857739319766 5.81536712859723 GILLQLFGGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GILLQLFGGTR 11 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 488727100.0 247382100.0 90225000.0 151120000.0 False True 205709177.03521773 89738940.01673979 182718493.3000665 1.0 0.43624179198080376 0.8882369563356175 27.616030915469633 -9.992942337858555 7.004454510518278 1.0000000298345464 0.6622393741582173 0.4267836480151457 0.184526253145787 8.605441033909915e-08 1.2162970432067119e-08 0.17866679231693447 0.05955559211430705 1.0163836311870776e-10 9.992942337858555 -0.33776065567632907 GILLQLFGGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GILLQLFGGTR 11 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 1900862820.0 655240000.0 622292820.0 623330000.0 False True 848221096.7113687 587661677.5276477 509890335.9059038 1.0 0.6928166250592754 0.601129042749344 29.65986512477596 -13.999999999999998 0.16944274133025214 2.5468874624361244 0.5197684321881295 0.9995147516612521 0.0037575091789119755 12.086152910075672 0.13034037826337697 6.1447983459482245 0.07513275979212099 1.0000000000000041e-14 13.999999999999998 -2.027119030247995 GILLQLFGGTRK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GILLQLFGGTRK 12 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 7251500.0 2445200.0 0.0 4806300.0 False True 3205680.8793504843 0.0 4308990.181285106 1.0 0.0 1.3441731549268146 21.612199383870443 -6.707485476670479 1.8039746660669183 0.3836547265913214 1.340813416958765 0.45322931165400726 0.4215638322014812 0.3801575591188822 2.4099841585455106 0.18606858655174824 0.47418290362385607 1.9611667581532829e-07 6.707485476670479 0.9571586903674437 GILLQLFGGTRK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GILLQLFGGTRK 12 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 128182900.0 28032800.0 37314000.0 62836100.0 False True 42527807.07219584 30655025.164387323 50416517.29295906 1.0 0.7208230867005885 1.1854953444312617 25.341903129153234 -6.744003864004216 1.671961369839712 0.8346663931186454 1.1860168624453116 0.6228082452160614 0.11729364911400633 0.31062107962713476 1.7064017837541117 0.05546414405114607 0.13551446200196288 1.8030016991241806e-07 6.744003864004216 0.35135046932666614 GILLQLFGGTRK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GILLQLFGGTRK 12 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 40821600.0 2445200.0 32727600.0 5648800.0 False True 3349256.5190453758 31281586.41629946 4314669.780687823 1.0 9.33985982811956 1.2882470351711415 21.675409445393335 -6.63798385929085 2.05166860665442 6.462256602428293 1.3216377215882318 0.1468534299500549 3.5702193724695044 0.5385468953897538 4.330046272917658 1.4182829164244752 3.953594964313701 2.3015273529030757e-07 6.63798385929085 -5.140618880840061 GILLQLFGGTRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GILLQLFGGTRK 12 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 120841800.0 28032800.0 36691000.0 56118000.0 False True 36289012.2090996 34649113.596018866 45905099.81930516 1.0 0.9548100509423753 1.2649862044962 25.113029451245684 -6.869892773564442 1.1345935907291564 0.9744559579171187 1.2831200700122363 0.9645796107581149 0.025749303365507428 0.13696134666273385 0.32958308091970046 0.017613314912036424 0.0416946645219531 1.3492959799376115e-07 6.869892773564442 0.30866411209511757 GILLYGPPGTGK(ub)TLIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GILLYGPPGTGKTLIAR 17 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 22156600.0 6460700.0 10559000.0 5136900.0 True False 8470040.265507804 8983638.358659625 4605382.864624234 1.0 1.060637030882052 0.5437262067547122 23.01393739728901 -6.877651240363934 1.0927568053539007 1.0365367958740526 0.508695624632636 0.9717435782968756 0.038782162014036774 0.129733731185159 0.28499895319184754 0.027393101725491142 0.06586895735993942 1.3254054731343988e-07 6.877651240363934 -0.5278411712414166 GILLYGPPGTGK(ub)TLIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GILLYGPPGTGKTLIAR 17 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 55030000.0 16725000.0 15322000.0 22983000.0 True False 16194074.029802147 21440154.50317447 16963062.824779212 1.0 1.3239506293300807 1.047485814475214 23.948962642020177 -10.561682830564571 8.586686864150888 0.9999679990971977 1.1857182219026474 0.37565688970971345 0.11286628803790774 6.915581700974611e-05 3.5301531890756964e-06 0.1093011009814461 0.03642743782658882 2.7435771011932855e-11 10.561682830564571 0.18575022280544973 GILLYGPPGTGK(ub)TLIAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GILLYGPPGTGKTLIAR 17 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 31761700.0 7490600.0 7465100.0 16806000.0 True False 11363787.836212955 6132894.579907483 13484286.733668517 1.0 0.5396875292201253 1.1866014156563336 23.437940465749485 -6.715641566721428 1.7751486066507964 0.7186504413216075 1.1853436302913414 0.49178248270058655 0.19381232421409408 0.3638673068494825 2.2384028475384894 0.08677573031545804 0.21895180074103826 1.9246795561288725e-07 6.715641566721428 0.4666931889697339 GILLYGPPGTGK(ub)TLIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GILLYGPPGTGKTLIAR 17 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 26452000.0 6460700.0 9947300.0 10044000.0 True False 8849395.383852636 9507795.394677754 7671814.062673213 1.0 1.0744005643624526 0.8669308726641213 23.0771474588119 -6.809705628341615 1.4156207787765551 1.0405615146644334 0.8633202630390033 0.8591033412589765 0.03221377804712396 0.20719556212942783 0.8183885597709293 0.01789286399054846 0.04139830484813053 1.5498667871464062e-07 6.809705628341615 -0.17724125162543003 GILLYGPPGTGK(ub)TLIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GILLYGPPGTGKTLIAR 17 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 44111400.0 16725000.0 18904000.0 8482400.0 True False 13907578.543128302 18802160.399849776 10256030.621813685 1.0 1.3519363087932998 0.7374418623636796 23.729367917454454 -6.751382649752071 1.6448589879607225 1.2065963683704446 0.7360988376946656 0.6548732853889583 0.14789638224523177 0.29762558381042636 1.5847547201328729 0.07101814858350938 0.1721544391936759 1.7726269600655556e-07 6.751382649752071 -0.47049753067577904 GILTLK(ub)YPIEHGIITNWDDMEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GILTLKYPIEHGIITNWDDMEK 22 1 P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P68133 ACTA1;ACTC1;ACTG2;ACTA2 Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 148729300.0 4583300.0 39519000.0 104627000.0 True False 6953201.1841127295 32466525.686643694 83947427.59035683 1.0 4.669291859528816 12.073205616740546 22.72924590243575 -6.959871286612995 0.43724666501474424 0.7275380962512806 16.302310259647697 0.9997653888987647 0.0705428775052047 0.07974717594284826 0.021301694090949168 0.09729284230839427 0.6137901451761054 1.0968032114131437e-07 6.959871286612995 15.574772163396418 GILTLK(ub)YPIEHGIITNWDDMEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GILTLKYPIEHGIITNWDDMEK 22 1 P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P68133 ACTA1;ACTC1;ACTG2;ACTA2 Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 8402300.0 3026000.0 3255500.0 2120800.0 True False 2516253.074529521 3237961.975333847 2564249.4745287234 1.0 1.286818884837038 1.0190745519538715 21.262845599255005 -10.58334629675259 2.815257089085885 0.9897475601715806 1.1529467181499027 0.3031792423528663 0.10930617012964709 17530898.83096187 16980337.773308016 1333081.7816465204 0.041216268108595626 2.6100793052813558e-11 10.58334629675259 0.16319915797832207 GILTLK(ub)YPIEHGIITNWDDMEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GILTLKYPIEHGIITNWDDMEK 22 1 P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P68133 ACTA1;ACTC1;ACTG2;ACTA2 Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 161409800.0 4583300.0 19068500.0 137758000.0 True False 5933172.200349814 18007321.21244136 112687457.51644467 1.0 3.0350242002717644 18.9927839124239 22.5003722245282 -6.930470938974407 0.7429243685906375 0.761517161249886 22.308378250368875 0.9966298385301777 0.4670505398730718 0.09239420868882928 0.0764898393306346 0.4267018694918213 1.4401832573919235 1.1736242134964424e-07 6.930470938974407 21.546861089118988 GILVFQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GILVFQLK 8 0 H0Y7R8;Q5TIG5;A8MQ02;J3KN01;P55196-2;P55196-6;P55196-3;P55196-1;P55196;P55196-5 H0Y7R8 MLLT4 Afadin 0 9526300.0 2072800.0 3727700.0 3725800.0 False True 2717460.8730237535 3171541.690460796 3340289.9563972354 1.0 1.1670974629091093 1.2291952349917192 21.37382783228569 -13.999999999999998 0.1374768843306305 0.20340224361039963 1.3084316644651097 0.9996131789833014 0.0019035599649176815 11.932388836268364 0.11597845461906227 2.5537973548801185 0.0707238681271669 1.0000000000000041e-14 13.999999999999998 1.10502942085471 GILVFQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GILVFQLK 8 0 H0Y7R8;Q5TIG5;A8MQ02;J3KN01;P55196-2;P55196-6;P55196-3;P55196-1;P55196;P55196-5 H0Y7R8 MLLT4 Afadin 0 8447800.0 2723800.0 2428600.0 3295400.0 False True 2637334.459932737 3398352.6449816944 2432235.8801191063 1.0 1.2885558114113318 0.9222326242918535 21.33064911098127 -6.696645308388244 1.8425282772099734 1.1797614009178536 0.9233764497833593 0.4018507640193678 0.12187848416551074 0.4025210473123641 2.654230971113044 0.052815241386736836 0.136407558519756 2.0107343242400166e-07 6.696645308388244 -0.25638495113449433 GILVFQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GILVFQLK 8 0 H0Y7R8;Q5TIG5;A8MQ02;J3KN01;P55196-2;P55196-6;P55196-3;P55196-1;P55196;P55196-5 H0Y7R8 MLLT4 Afadin 0 12323200.0 2072800.0 4311300.0 5939100.0 False True 2839170.175313779 4120812.5104374248 4536406.899603997 1.0 1.4514144119529577 1.5977932351669069 21.437037893808583 -11.763645587900616 0.193924398864342 1.2454945014813574e-09 1.7121836787327125 0.9994147209775074 0.006155024684279327 4.692625489741568 0.11965701308270314 2.0211390719798845 0.09660578596343174 1.7232743034759505e-12 11.763645587900616 1.712183677487218 GILVFQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GILVFQLK 8 0 H0Y7R8;Q5TIG5;A8MQ02;J3KN01;P55196-2;P55196-6;P55196-3;P55196-1;P55196;P55196-5 H0Y7R8 MLLT4 Afadin 0 5862900.0 2723800.0 1293800.0 1845300.0 False True 2264960.3847995703 1286830.0426008056 2231143.698296799 1.0 0.5681468211262685 0.9850696344493619 21.111054386415546 -10.738371125323187 9.959299635986065 1.0005538941968706 0.7766082288218056 0.2768249352157819 0.1702080257945372 0.002098182608580757 5.51187920538064e-05 0.16518522407486058 0.054934404107757046 1.8265386847197173e-11 10.738371125323187 -0.223945665375065 GINILISTPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GINILISTPGR 11 0 F8WAJ0;Q9H8H2-4;Q9H8H2-2;Q9H8H2 F8WAJ0 DDX31 Probable ATP-dependent RNA helicase DDX31 0 5713900.0 1564000.0 1534200.0 2615700.0 False True 1514351.6760903178 2146814.0607473054 1930569.7006820254 1.0 1.4176456464127603 1.2748489873014701 20.530268848911344 -10.039966140087651 5.048370078477339 0.999995070757279 1.346247316859162 0.886868450943145 0.05829649197324429 3.234320878598164e-06 6.15052565954506e-07 0.056446139548279727 0.01881511187853879 9.120819473533815e-11 10.039966140087651 0.346252246101883 GINILISTPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GINILISTPGR 11 0 F8WAJ0;Q9H8H2-4;Q9H8H2-2;Q9H8H2 F8WAJ0 DDX31 Probable ATP-dependent RNA helicase DDX31 0 12710900.0 3120900.0 3623600.0 5966400.0 False True 4734633.468351933 2976940.2686839737 4787138.42483398 1.0 0.6287583375952879 1.01108955040195 22.17482131310469 -10.973311525018232 10.973498857252045 1.091746606155434 0.8199239441801306 0.22826501565026214 0.15608606401929517 0.08349181558174588 0.00020305899269993058 0.036015776682841116 0.05037656054348292 1.0633799684546165e-11 10.973311525018232 -0.27182266197530336 GINILISTPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GINILISTPGR 11 0 F8WAJ0;Q9H8H2-4;Q9H8H2-2;Q9H8H2 F8WAJ0 DDX31 Probable ATP-dependent RNA helicase DDX31 0 3756200.0 1564000.0 840400.0 1351800.0 False True 1300535.2969478427 835872.5983936602 1634455.1299829911 1.0 0.6427142733882927 1.2567556865383103 20.31067412434562 -6.748937324013118 1.6535319866515776 0.7896514155963051 1.2578982264256624 0.6445245676308848 0.1501268390883605 0.30188251587497295 1.6235970559156856 0.0717283096108662 0.1743484493028684 1.7826360131978604e-07 6.748937324013118 0.46824681082935726 GINILISTPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GINILISTPGR 11 0 F8WAJ0;Q9H8H2-4;Q9H8H2-2;Q9H8H2 F8WAJ0 DDX31 Probable ATP-dependent RNA helicase DDX31 0 13410900.0 3120900.0 5735600.0 4554400.0 False True 4040066.572136176 5416408.818002394 3725545.932090305 1.0 1.340673160031242 0.9221496392621152 21.94594763519714 -6.690201449638472 1.8653160710881294 1.2135314581171601 0.9235756606003999 0.3715890050889499 0.1440734899431767 0.4162089482988759 2.8077866055353673 0.061780608717320405 0.16086291997148508 2.0407910940665057e-07 6.690201449638472 -0.28995579751676026 GINSSNVENQLQATQAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GINSSNVENQLQATQAAR 18 0 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 0 7591400.0 2393000.0 0.0 5198400.0 False True 2317035.524861976 0.0 3836783.0913428343 1.0 0.0 1.655901711550749 21.14384873314249 -6.74320064490121 1.6749962900517776 0.40722467785865735 1.6575638069452407 0.619230094919796 0.420139510431573 0.31204923009166075 1.7202048346419718 0.19833679843600005 0.48499785802794654 1.8063394008625145e-07 6.74320064490121 1.2503391290865835 GINTLVTYDMVPEPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GINTLVTYDMVPEPK 15 0 H3BNX8;P20674 H3BNX8 COX5A Cytochrome c oxidase subunit 5A, mitochondrial 0 35950100.0 7133100.0 11871000.0 16946000.0 False True 9351563.177038651 10099893.072795583 15192590.477510203 1.0 1.080021904529752 1.6246043778876789 23.15677611071656 -6.933231371934484 0.7197710098048025 0.9926293717505484 1.7461980376223953 0.9971361628812591 0.014850878195089269 0.09099415644651414 0.06971188189745793 0.01380003562871552 0.04842952072369866 1.1661881606313997e-07 6.933231371934484 0.7535686658718469 GINTLVTYDMVPEPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GINTLVTYDMVPEPK 15 0 H3BNX8;P20674 H3BNX8 COX5A Cytochrome c oxidase subunit 5A, mitochondrial 0 38255100.0 7133100.0 11574000.0 19548000.0 False True 9770399.834779378 11062622.409900213 14931165.003697354 1.0 1.1322589246062327 1.5282040915610604 23.21998617223945 -6.951497759058562 0.542150778010348 0.994251716847401 1.6845635967931414 0.9993136440381556 0.005879347410358978 0.08288982701511033 0.03351594945625909 0.006447682110830885 0.03280133656872661 1.118155594205629e-07 6.951497759058562 0.6903118799457404 GIPEFWFTIFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIPEFWFTIFR 11 0 Q99733;Q99733-2;C9J6D1;C9JZI7;A8MXH2;H0YCI4 Q99733 NAP1L4 Nucleosome assembly protein 1-like 4 0 936590000.0 356890000.0 241030000.0 338670000.0 False True 541428222.1539054 198016313.32401466 271731726.0556661 1.0 0.3657295745247039 0.5018795011731474 29.012194849644565 -9.931656655971322 6.979446771125431 1.0000000197934176 0.43380453785041134 0.9584351648537102 0.05558297480101502 1.7118343211859965e-08 2.6427397716571e-09 0.053817985538141405 0.01793932797808201 1.1704243380679877e-10 9.931656655971322 -0.5661954819430062 GIPEFWFTIFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIPEFWFTIFR 11 0 Q99733;Q99733-2;C9J6D1;C9JZI7;A8MXH2;H0YCI4 Q99733 NAP1L4 Nucleosome assembly protein 1-like 4 0 899310000.0 356890000.0 264860000.0 277560000.0 False True 462001140.35364205 250120308.16934797 227046928.00610048 1.0 0.5413846121199866 0.491442354086628 28.783321171737015 -13.999999999999998 0.31312875482549657 5.515217649364884 0.4807490176947741 0.9996788511758778 0.004101576055320713 17.495603833098034 0.1781674476245843 51.558817699124035 0.017087904805330893 1.0000000000000041e-14 13.999999999999998 -5.03446863167011 GIPEFWLTVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIPEFWLTVFK 11 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 188097000.0 91912000.0 68810000.0 27375000.0 False True 120497522.07707416 58543816.21927925 24542497.5995422 1.0 0.4858507893783302 0.20367636758409038 26.844428238136096 -8.846701332022352 0.24552501401858579 1.2951984113978328 4.02774919767383e-21 0.9992565568979275 0.008988657882363277 0.35633505026518364 0.07706877807819085 0.20462629413716757 0.11510560475784017 1.4233072710416032e-09 8.846701332022352 -1.2951984113978328 GIPEFWLTVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIPEFWLTVFK 11 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 977480000.0 427580000.0 218910000.0 330990000.0 False True 414006706.94545925 306321904.6005689 244293789.51284295 1.0 0.739895995551887 0.5900720578061213 28.625078898800737 -13.05978687129171 0.06809725871663655 2.3809113967367623 3.3741989655745113e-21 0.9999452355149702 0.001253294588797764 8.908237569956894 0.06127213006152812 2.210553993731354 0.49527664158733187 8.713911176086616e-14 13.05978687129171 -2.3809113967367623 GIPEFWLTVFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIPEFWLTVFK 11 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 1980230000.0 739550000.0 594100000.0 646580000.0 False True 1121951418.347167 488078213.2755134 518783179.5939186 1.0 0.4350261564752411 0.4623936216045594 30.063363061103153 -10.653447052775377 6.593162972621105 1.0028608832969121 0.4487098890399012 0.9981551198396261 0.011172720853373562 0.0004713924322820852 2.4777495253374034e-05 0.010853565559768796 0.0036059801497450093 2.2210224439853213e-11 10.653447052775377 -0.5541509942570109 GIPEFWLTVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIPEFWLTVFK 11 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 401268000.0 91912000.0 79616000.0 229740000.0 False True 125894350.22840609 76098301.86509556 175480143.64382184 1.0 0.6044616118756151 1.3938682977071952 26.907638299658988 -6.77045874771649 1.572778518509974 0.7732773463421144 1.39838281018944 0.7323807880082456 0.1667186337781351 0.26563584478888813 1.2968575222060397 0.08355345909181874 0.19880175710611614 1.6964507351917713e-07 6.77045874771649 0.6251054638473256 GIPEFWLTVFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIPEFWLTVFK 11 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 889380000.0 427580000.0 181290000.0 280510000.0 False True 355551715.0057281 180313354.78675255 339163344.06830084 1.0 0.5071367881992852 0.9539072088650641 28.405484174235013 -10.40983615050086 8.72275869183833 1.0000019171958048 0.7305219985321748 0.32663721201341134 0.18239326046662516 6.800442431991108e-06 4.600835424365702e-07 0.17660277006363526 0.058867171687309254 3.8919195063208096e-11 10.40983615050086 -0.26947991866362997 GIPEFWLTVFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIPEFWLTVFK 11 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 2211740000.0 739550000.0 871470000.0 600720000.0 False True 957362053.7099267 822971928.416303 491395123.90771294 1.0 0.859624553978465 0.5132803436312109 29.834489383195603 -6.955743358157686 0.49176704401101545 1.0074595032189806 0.3507147180180541 0.9995783140606214 0.00420036906834059 0.08125819131258769 0.027027623877593717 0.005005721538685541 0.028565589603689077 1.1072779251427887e-07 6.955743358157686 -0.6567447852009265 GIPHLVTHDAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIPHLVTHDAR 11 0 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 17357100.0 1904200.0 7469500.0 7983400.0 False True 2496424.6402990315 6355079.715882963 7157354.350180274 1.0 2.5456725643926212 2.8670420226756526 21.25143192593897 -10.203934955874765 0.3554680049369903 1.85997979257055e-14 2.9268087249923638 0.9989763407494627 0.026076102324398914 1.6058538894625929 0.16351666250356922 1.6650535640947166 0.0933980574467137 6.252663316724973e-11 10.203934955874765 2.926808724992345 GIPHLVTHDAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIPHLVTHDAR 11 0 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 13847220.0 728820.0 1661400.0 11457000.0 False True 705684.0080358975 2324805.684086544 8456067.997367417 1.0 3.294400408133215 11.982796692393325 19.428662790948035 -6.946134242693711 0.599785637490288 0.9020917044311194 14.819703647846788 0.9988619321628748 0.15957500633180705 0.08507619122124899 0.042680152730274715 0.16381310204350374 0.7300996005868325 1.1320503864586676e-07 6.946134242693711 13.917611943415668 GIPHLVTHDAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIPHLVTHDAR 11 0 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 17507800.0 1904200.0 8225000.0 7378600.0 False True 2608234.1990700983 7861592.303562233 5635926.6470370935 1.0 3.014143555960232 2.1608207763882725 21.31464198746186 -10.637011978484715 6.307061029726141 0.9918469777037061 2.587482166173362 0.821891474768343 0.3483675659741253 0.039586495084410825 0.0022783039770551666 0.3343355834637945 0.11243514844804987 2.306683566095239e-11 10.637011978484715 1.5956351884696556 GIPILSLDWLHQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIPILSLDWLHQSR 14 0 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 0 29111600.0 5252100.0 11697000.0 12162500.0 False True 6885553.961408745 9951853.194548884 10904041.17093815 1.0 1.445323535379395 1.5836113161049492 22.715141297065326 -11.826186889833647 0.19949058073377404 1.4987187641422552e-16 1.6852374997527353 0.9994002982524366 0.006097873050106716 4.825163107548692 0.12291365267217247 2.111020352881418 0.08764287993208282 1.4921521539421676e-12 11.826186889833647 1.685237499752735 GIPILSLDWLHQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIPILSLDWLHQSR 14 0 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 0 42413700.0 14551400.0 10124600.0 17737700.0 False True 14089473.772033665 14167405.579091491 13091664.250406215 1.0 1.0055312077880803 0.9291804975989939 23.748114393626675 -6.889483682464286 1.0254537861283703 1.0041533548777442 0.9226801976604087 0.9805649331097009 0.004846125135848363 0.11956223793491916 0.2243133999671293 0.003603315596349919 0.00896640957690293 1.2897820173419073e-07 6.889483682464286 -0.0814731572173355 GIPILSLDWLHQSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIPILSLDWLHQSR 14 0 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 0 9148400.0 0.0 4254900.0 4893500.0 False True 0.0 3495579.8513145605 3926297.580102759 0.0 GIPILSLDWLHQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIPILSLDWLHQSR 14 0 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 0 70317400.0 5252100.0 16669300.0 48396000.0 False True 7193943.302665712 15932795.20799635 36965861.54690695 1.0 2.2147512897540436 5.1384699589179785 22.778351358588218 -6.956270135929436 0.4851509384208255 0.9331136577122173 6.543072215324395 0.9996058836576721 0.03448111951071554 0.08106139556172563 0.026266394793562256 0.04166391595263991 0.24114967321547132 1.1059356658814732e-07 6.956270135929436 5.6099585576121775 GIPILSLDWLHQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIPILSLDWLHQSR 14 0 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 0 31350800.0 14551400.0 5711100.0 11088300.0 False True 12100133.83632151 5680333.170735413 13406812.263493428 1.0 0.46944382992562483 1.1079887582110541 23.52851966906095 -6.686155376284074 1.880242969837743 0.6661819104620187 1.1056758606417996 0.3524385208627687 0.22456625920667586 0.42497416857906317 2.9098570681543485 0.09565857971076201 0.2503002528500419 2.0598928195116026e-07 6.686155376284074 0.4394939501797809 GIPILSLDWLHQSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIPILSLDWLHQSR 14 0 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 0 16580300.0 0.0 7182400.0 9397900.0 False True 0.0 6782693.126162985 7687578.6305971 0.0 GIPNYEFK(ub)LGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIPNYEFKLGK 11 1 Q92890;Q92890-1 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 1 7639810.0 0.0 2799610.0 4840200.0 True False 0.0 2381919.1007943084 4339382.534476859 0.0 GIPNYEFK(ub)LGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIPNYEFKLGK 11 1 Q92890;Q92890-1 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 1 15241800.0 5380500.0 2454200.0 7407100.0 True False 5209698.9726367965 3434174.8584839245 5466958.30176313 1.0 0.6591887317331462 1.0493808433995038 22.312768582282672 -6.6758947868302485 1.9165575405434534 0.7835757331032832 1.047849464617392 0.3054300862475009 0.14457515626981596 0.447690944747847 3.1757282013630386 0.0606111742762862 0.1606986152956173 2.1091390528724264e-07 6.6758947868302485 0.2642737315141087 GIPNYEFK(ub)LGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIPNYEFKLGK 11 1 Q92890;Q92890-1 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 1 4839900.0 0.0 3163100.0 1676800.0 True False 0.0 3023343.7830270724 1280774.3747800118 0.0 GIPNYEFK(ub)LGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIPNYEFKLGK 11 1 Q92890;Q92890-1 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 1 16776400.0 5380500.0 7369400.0 4026500.0 True False 4474124.146565131 7329699.579488633 4868422.533567485 1.0 1.6382423328855953 1.0881286200574172 22.09317385771695 -10.495276994861552 4.4035966002667575 0.9978246504993739 1.3631854764708524 0.3675502732762034 0.22458298282436504 0.0048227900977723115 0.0005527689961644505 0.2186466602198606 0.07248384602648165 3.196855491337934e-11 10.495276994861552 0.36536082597147856 GIPTYIYYFPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIPTYIYYFPR 11 0 Q86WJ1;Q86WJ1-2;Q86WJ1-4;A0A0A0MSH9;A0A494C1P7;Q86WJ1-3;Q86WJ1-5;A0A0A0MRH8;A0A494C179 Q86WJ1 CHD1L Chromodomain-helicase-DNA-binding protein 1-like 0 2935470.0 991090.0 1142500.0 801880.0 False True 1299328.5877292138 972043.4534301205 718909.149776106 1.0 0.7481121116013641 0.5532927979615346 20.30933488997971 -6.973993084728185 0.13150869698601791 1.295138728741326 0.0012181921031016757 0.9999991797126664 0.0001655176993552782 0.07502697502571626 0.003953086086782039 0.012056651606745303 0.026415609783123763 1.0617124627135819e-07 6.973993084728185 -1.2939205366382245 GIPVVEHK(ub)VEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIPVVEHKVEK 11 1 P11388;P11388-2;P11388-3;P11388-4;J3KTB7;Q02880;Q02880-2;E9PCY5 P11388;Q02880 TOP2A;TOP2B DNA topoisomerase 2-alpha;DNA topoisomerase 2-beta;DNA topoisomerase 2 1 2671250.0 970470.0 927020.0 773760.0 True False 1272295.5680448494 788712.229495658 693698.7376300195 1.0 0.6199127382858691 0.5452339496049916 20.279002432570934 -13.999999999999998 0.22877389270925724 3.3858437978038483 0.5084982853390181 0.9995081435969275 0.004416148621601085 13.253402765799319 0.1514547505035872 14.353415173751428 0.0390629115325395 1.0000000000000041e-14 13.999999999999998 -2.87734551246483 GIPVVEHK(ub)VEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIPVVEHKVEK 11 1 P11388;P11388-2;P11388-3;P11388-4;J3KTB7;Q02880;Q02880-2;E9PCY5 P11388;Q02880 TOP2A;TOP2B DNA topoisomerase 2-alpha;DNA topoisomerase 2-beta;DNA topoisomerase 2 1 4468390.0 782290.0 2522700.0 1163400.0 True False 650508.7963230988 2509109.7143832576 1406661.5610461694 1.0 3.8571495551875934 2.162402059737098 19.311209039951613 -10.096385645901965 6.060594931741165 0.9999932902670694 3.009775807462391 0.652185765162833 0.6918777677857398 6.272619716004099e-05 9.352294041611417e-06 0.6699099981237019 0.22330258935375402 8.009665032659442e-11 10.096385645901965 2.0097825171953216 GIPVVEHKVEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIPVVEHKVEK 11 1 P11388;P11388-2;P11388-3;P11388-4;J3KTB7;Q02880;Q02880-2;E9PCY5 P11388;Q02880 TOP2A;TOP2B DNA topoisomerase 2-alpha;DNA topoisomerase 2-beta;DNA topoisomerase 2 1 6809800.0 2113400.0 1988500.0 2707900.0 True False 2046311.273816674 2782518.419890508 1998619.7547413132 1.0 1.3597728046040125 0.9766939078694469 20.964594186076354 -6.660288645598479 1.971593467722942 1.231520856448 0.9782806750247043 0.23696734326292557 0.15317141073739 0.4837445196690758 3.615020287601747 0.06275583151028216 0.16983279928432995 2.1863080527372182e-07 6.660288645598479 -0.25324018142329574 GIPVVEHKVEK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIPVVEHKVEK 11 1 P11388;P11388-2;P11388-3;P11388-4;J3KTB7;Q02880;Q02880-2;E9PCY5 P11388;Q02880 TOP2A;TOP2B DNA topoisomerase 2-alpha;DNA topoisomerase 2-beta;DNA topoisomerase 2 1 10421000.0 2113400.0 5994600.0 2313000.0 True False 1757385.739494611 5962305.899965069 2796637.6058963295 1.0 3.392713259229991 1.591362410110706 20.74499946151063 -6.573866722043365 2.2914532988467156 2.635346473521158 1.5953997115200949 0.0 1.041076867139582 0.7178823117165902 7.0814545029067375 0.38301261027231087 1.1654786549593863 2.6676772059311157e-07 6.573866722043365 -1.0399467620010632 GIPVVEHKVEK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIPVVEHKVEK 11 1 P11388;P11388-2;P11388-3;P11388-4;J3KTB7;Q02880;Q02880-2;E9PCY5 P11388;Q02880 TOP2A;TOP2B DNA topoisomerase 2-alpha;DNA topoisomerase 2-beta;DNA topoisomerase 2 1 15511300.0 3292300.0 1637000.0 10582000.0 True False 4261947.250935282 1545899.5109613503 8656184.580489097 1.0 0.3627214087696894 2.031039820727369 22.023081306676367 -6.80317277534399 1.4428798218520218 0.6497818862751454 2.0559240700391594 0.8412776002155427 0.2738530860128714 0.21626736132651947 0.8885318651415048 0.1492874005621573 0.3465453599173148 1.5733568115106132e-07 6.80317277534399 1.406142183764014 up GIQDNSPQHSVENK(ub)PK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIQDNSPQHSVENKPK 16 1 Q96M89-2;Q96M89 Q96M89-2 CCDC138 Coiled-coil domain-containing protein 138 1 15408050.0 917850.0 7489500.0 7000700.0 True False 1392445.5538232008 6152940.209269407 5617008.576484191 1.0 4.418801289842495 4.033916127680339 20.409189487004436 -10.175223133871157 6.083247324966687 0.9999689979186716 4.226358708761438 0.9894394263059011 0.15712870947768423 6.606713613758919e-05 8.958440857091987e-06 0.15214065406716246 0.050713072918166555 6.680006208702605e-11 10.175223133871157 3.2263897108427666 GIQDNSPQHSVENK(ub)PK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIQDNSPQHSVENKPK 16 1 Q96M89-2;Q96M89 Q96M89-2 CCDC138 Coiled-coil domain-containing protein 138 1 11277850.0 917850.0 6185300.0 4174700.0 True False 1188174.9185283713 5841082.617684327 3414947.4360393016 1.0 4.9160123872324055 2.8741117008840136 20.180315809096886 -9.741062229393286 9.559250730473451 1.0000818412291892 3.8950620440582093 0.7282838629629621 0.8336024658378846 0.0 0.0 0.8071321162817919 0.2690440387605973 1.8152555389423348e-10 9.741062229393286 2.89498020282902 GIRPAINVGLSVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIRPAINVGLSVSR 14 1 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 241151000.0 79053000.0 90424000.0 71674000.0 False True 103639248.55034108 76933091.66999127 64257862.025555655 1.0 0.7423161856738306 0.6200147427192454 26.626995219322108 -13.999999999997343 0.09900986307096422 2.2763640522590185 0.35548060737730924 0.9997986669595704 0.0022472231711111296 12.088060467114484 0.09350584668749551 3.160545172957554 0.23606732228242014 1.000000000006119e-14 13.999999999997343 -1.9208834448817091 GIRPAINVGLSVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIRPAINVGLSVSR 14 1 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 520917970.0 190927970.0 116470000.0 213520000.0 False True 184867066.10103714 162977078.38302612 157592706.5373042 1.0 0.8815906576564195 0.8524650164089993 27.46191299192803 -13.999999999996895 0.19698185358406078 1.6508094090016563 0.832976882538559 0.9994870501509211 0.0014449894120147524 12.472781566235357 0.14073979435388315 3.123653939699781 0.01897177647813905 1.0000000000071498e-14 13.999999999996895 -0.8178325264630973 GIRPAINVGLSVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIRPAINVGLSVSR 14 1 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 2258926900.0 591956900.0 626370000.0 1040600000.0 False True 898041895.1462262 514589379.64885247 834924953.8888179 1.0 0.5730126650328079 0.9297171528427066 29.74220750975554 -10.03315858866285 7.0945030215182765 1.0000000343797812 0.7513649089377572 0.393133250674366 0.14562399734917938 7.915765874608285e-08 1.095767864528297e-08 0.14099984804488852 0.04699994304512702 9.264914403811384e-11 10.03315858866285 -0.24863512544202404 GIRPAINVGLSVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIRPAINVGLSVSR 14 1 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 453513000.0 79053000.0 148760000.0 225700000.0 False True 108281030.4269975 142187291.31646413 172394308.43740973 1.0 1.3131320486678049 1.592100737844724 26.690205280845 -6.9724907942513665 0.189468767658063 0.8096129978422705 2.1032365955933217 0.9999958538583422 0.0004924396737988446 0.0755024370149845 0.006040649702377648 0.009893575827360918 0.0304555501625575 1.0653914465515633e-07 6.9724907942513665 1.293623597751051 GIRPAINVGLSVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIRPAINVGLSVSR 14 1 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 399191970.0 190927970.0 93894000.0 114370000.0 False True 158765066.59820905 93388174.38550024 138284238.21286792 1.0 0.5882161383891845 0.8709991509834307 27.242318267362307 -10.074523568042816 5.478990152793846 1.000002297831356 0.7296076446861727 0.5493563650246316 0.11544568146429697 3.240411878286569e-06 5.475250756730999e-07 0.11178074975503567 0.037259933475163556 8.423186797330994e-11 10.074523568042816 -0.2703946531451834 GIRPAINVGLSVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIRPAINVGLSVSR 14 1 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 2464496900.0 591956900.0 1078200000.0 794340000.0 False True 766299876.2649735 1018197222.1860275 649778270.6166815 1.0 1.3287190220476457 0.847942549310812 29.51333383184799 -6.7227135875870445 1.7501842638166776 1.1994147809878692 0.8486078376159826 0.5250175228096532 0.1382820785177444 0.3500661047694453 2.097176543329005 0.06270872708376515 0.15688454580554867 1.8935920099607372e-07 6.7227135875870445 -0.35080694337188667 GISCMNTTLSESPFK ddPTM_RPMI8226_Bortezomib_1h_R1 2 GISCMNTTLSESPFK 15 0 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 44792100.0 8617100.0 18916200.0 17258800.0 False True 11297101.548115097 16093976.694770068 15473024.934099702 1.0 1.4246111381954711 1.3696455562693735 23.429449337866107 -10.160846086592782 4.397847199350647 0.9999221477256764 1.3971283472479392 0.9858360020548455 0.02243960497994385 2479326.4595676097 5728272.013906073 1137.0379304320554 0.007681673097107206 6.90484467292841e-11 10.160846086592782 0.39720619952226277 GISCMNTTLSESPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GISCMNTTLSESPFK 15 0 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 15112800.0 7297700.0 1990900.0 5824200.0 False True 7066038.5080590155 2785876.752406344 4298667.297745248 1.0 0.3942628884952966 0.6083560530900727 22.75247018088424 -10.280112496886957 5.171800682979817 1.0000943440870966 0.5013094707926086 0.8785564879967865 0.08740316844614428 9.50973845591216e-05 1.3237156921836658e-05 0.0846436557761722 0.028209251316425953 5.246715350605762e-11 10.280112496886957 -0.49878487329448806 GISCMNTTLSESPFK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GISCMNTTLSESPFK 15 0 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 45189500.0 8617100.0 18905100.0 17667300.0 False True 11803074.738371456 18069810.171194457 13494647.609464994 1.0 1.5309409261342746 1.1433162890678208 23.492659399388998 -10.4553301176952 10.093187510508901 0.9999989328531387 1.3371286076010458 0.5021340255027972 0.15824709542405516 3.818536897768745e-06 2.060792692849103e-07 0.15322257979900383 0.05107403043025514 3.504853603102552e-11 10.4553301176952 0.3371296747479071 GISDLAQHYLMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 GISDLAQHYLMR 12 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 418968500.0 137362500.0 104400900.0 177205100.0 False True 180083567.7203423 88824692.6715209 158869616.12334758 1.0 0.4932415200117519 0.8821994040570177 27.4240913031974 -9.815864147052723 6.303342088843345 1.0000000107282818 0.6877204620342592 0.46220657706722035 0.15879139122437771 2.380698293636483e-08 4.725036884738303e-09 0.15374910801515546 0.05124970114435965 1.5280439754609697e-10 9.815864147052723 -0.31227954869402264 GISDLAQHYLMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 GISDLAQHYLMR 12 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 508590100.0 136435500.0 66367400.0 305787200.0 False True 132104429.73351707 92868248.92141885 225692358.90063617 1.0 0.702991179847292 1.7084389929687143 26.977103603029807 -6.827579197918912 1.3386185109218842 0.8410089890165618 1.734194284304133 0.9009542629246372 0.1327381447678502 0.18382182262558916 0.6450366930593827 0.07787393268317874 0.17924397684994478 1.4873761115169554e-07 6.827579197918912 0.8931852952875711 GISDLAQHYLMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GISDLAQHYLMR 12 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 141512000.0 43220600.0 56145000.0 42146400.0 False True 65568810.04910491 46125486.087112784 33816145.56657662 1.0 0.7034668778123182 0.5157352335851679 25.96650637710256 -8.930594386268153 0.1087771423655077 1.595280352559642 4.16425056556201e-09 0.9999550356109959 0.0013367828965903032 0.41956865195744997 0.03364620395413926 0.27321414648951226 0.19790764676883318 1.173290660688393e-09 8.930594386268153 -1.5952803483953915 GISDLAQHYLMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GISDLAQHYLMR 12 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 438014700.0 137362500.0 140144400.0 160507800.0 False True 188149128.33198532 133952357.01244324 122599163.4019055 1.0 0.7119477948156476 0.6516063321089736 27.48730136472029 -13.999999999999998 0.2197052297866686 2.735987884448295 0.6192382458493116 0.9994975975058535 0.003407443800746541 12.991620614420421 0.14849219298187236 9.783449725127879 0.03345948271201744 1.0000000000000041e-14 13.999999999999998 -2.1167496385989835 GISDLAQHYLMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GISDLAQHYLMR 12 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 308395700.0 136435500.0 83716900.0 88243300.0 False True 113452163.36747284 83265900.44319634 106694566.03907977 1.0 0.733929596154964 0.9404365934697504 26.757508878464083 -9.853441418601033 5.501928692954509 1.0000000800600652 0.8371830951633159 0.4532038722217697 0.08430612862680524 8.283233489004358e-08 1.724427620004603e-08 0.08162909817694007 0.02720968601229138 1.401388603616741e-10 9.853441418601033 -0.16281698489674934 GISDLAQHYLMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GISDLAQHYLMR 12 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 186076600.0 43220600.0 89712000.0 53144000.0 False True 55949918.705395475 84719448.33681394 43472337.303488284 1.0 1.514201455464208 0.77698660354436 25.73763269919501 -6.7191566007922585 1.7622400622275156 1.31311457202119 0.7781823077308585 0.5085683132433778 0.2164007431965003 0.35696698201617805 2.1660048772140117 0.09751877612223843 0.24506196339490333 1.9091647151253583e-07 6.7191566007922585 -0.5349322642903316 GISEETTTGVHNLYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GISEETTTGVHNLYK 15 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 21594000.0 1903000.0 4202100.0 15488900.0 False True 2494851.428678218 3575163.0596575094 13886257.208020069 1.0 1.4330164187579078 5.565965591537073 21.250522473266983 -6.926967761747648 0.7712727309184982 0.929578963602988 6.352444280061909 0.9959080028067696 0.13164510163441526 0.09424336374412742 0.08561903620366366 0.1178381831373312 0.3803868798216179 1.183129377720151e-07 6.926967761747648 5.422865316458921 up GISEETTTGVHNLYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GISEETTTGVHNLYK 15 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 21187440.0 6731300.0 2688440.0 11767700.0 False True 6517618.5660273405 3761948.112029389 8685386.346567212 1.0 0.5771967282096404 1.332601203734017 22.635913492280828 -6.7548539099122475 1.6322147816819923 0.7528421589453452 1.3346454230802867 0.6694628034047445 0.177723033618983 0.2916503482956659 1.5301586306399013 0.08596940330331859 0.207630720746717 1.7585150523143408e-07 6.7548539099122475 0.5818032641349414 GISEETTTGVHNLYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GISEETTTGVHNLYK 15 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 32314900.0 1903000.0 15317600.0 15094300.0 False True 2606590.5266413204 14640817.783470497 11529337.216866622 1.0 5.616846080667562 4.423148591628836 21.313732534789875 -10.074787730778226 6.50522766576482 0.999996151082886 5.019997336148213 0.9379719478265763 0.48732495923111807 2.72178574471753e-05 3.865095610184108e-06 0.4718508112136613 0.15728345427443635 8.418064891386935e-11 10.074787730778226 4.020001185065327 GISEETTTGVHNLYK(ub)MMANGILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GISEETTTGVHNLYKMMANGILK 23 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 12865100.0 5655000.0 1642400.0 5567700.0 True False 5475485.120390494 2298218.8850028515 4109352.3425803054 1.0 0.41972881570700893 0.7505001387506719 22.384555360481173 -10.232647402519833 5.73852362823669 1.000016385408335 0.585114477228857 0.6771779394096223 0.1350368271670717 2.8309199290735633e-05 3.7855413787098767e-06 0.13075400259802658 0.04358294856189268 5.852650596390865e-11 10.232647402519833 -0.41490190817947803 GISEETTTGVHNLYK(ub)MMANGILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GISEETTTGVHNLYKMMANGILK 23 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 54397000.0 11817000.0 18629000.0 23951000.0 True False 17927252.938419957 15304509.400958655 19217074.351903796 1.0 0.8537007568047144 1.071947521347212 24.095651099671084 -6.726094193240311 1.7377072728202931 0.911576285976726 1.0717224385617659 0.5409833424630088 0.06152176144398025 0.34359840807531294 2.030809205918068 0.02807900174475746 0.06998006590220854 1.878909259828288e-07 6.726094193240311 0.16014615258503984 GISEETTTGVHNLYK(ub)MMANGILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GISEETTTGVHNLYKMMANGILK 23 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 21447400.0 5655000.0 10045400.0 5747000.0 True False 4702383.058977008 9991283.436344212 6948671.128874284 1.0 2.124727677654953 1.4776914261821008 22.16496063591545 -10.148024839584245 5.342807718742562 0.9999775194686509 1.8012095519188385 0.6715320504552749 0.26415144353303005 7.073621711417455e-05 1.127977279353314e-05 0.25577069582316825 0.08525451180651511 7.111728367773344e-11 10.148024839584245 0.8012320324501876 GISEETTTGVHNLYK(ub)MMANGILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GISEETTTGVHNLYKMMANGILK 23 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 63226600.0 11817000.0 26932000.0 24477600.0 True False 15297339.447894271 25433210.524869286 20022927.961385354 1.0 1.6625904531634257 1.3089157124078576 23.866777421763533 -10.017733479320276 4.276822974590057 0.999970325869017 1.4857530824540985 0.7155161271677601 0.14438710876011224 100475318.57589468 297961295.62298334 50740.05405183941 0.052840273976958445 9.599895834713642e-11 10.017733479320276 0.4857827565850815 GISHVIVDEIHER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GISHVIVDEIHER 13 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 8540630.0 1653300.0 953430.0 5933900.0 False True 1600816.8964706648 1334139.571071766 4379633.576815794 1.0 0.8334117249843848 2.735874156795578 20.61037686927029 -6.885569673901999 1.0482683093229948 0.8866597192943575 2.88595802199648 0.9779065122583014 0.12786750610095618 0.1228099687629802 0.2434526526295199 0.0934430831948245 0.2295264550936255 1.3014585057272696e-07 6.885569673901999 1.9992983027021227 up GISICFSMLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GISICFSMLK 10 0 E7ESC6;Q9UIA9;E5RIW1 E7ESC6 XPO7 Exportin-7 0 33197900.0 9340900.0 8934000.0 14923000.0 False True 14170828.211262329 7339657.898339402 11973462.509016754 1.0 0.5179413502808662 0.8449373833704928 23.75642074295891 -9.945367946777806 5.613840827598125 1.0000003825213035 0.6814393668252389 0.5585826139423263 0.1334955714988649 6.391937711747168e-07 1.199114729911215e-07 0.12925668634689894 0.0430855104337353 1.1340496090984469e-10 9.945367946777806 -0.31856101569606465 GISICFSMLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GISICFSMLK 10 0 E7ESC6;Q9UIA9;E5RIW1 E7ESC6 XPO7 Exportin-7 0 22733500.0 9340900.0 5495300.0 7897300.0 False True 12091979.186666291 5189481.724243067 6460072.433140857 1.0 0.42916727229943125 0.5342444221425982 23.52754706505136 -9.91585875197397 5.70801988207363 1.0000003359514458 0.48170584722062915 0.9700952885253525 0.0428975667927413 1.833835769429407e-07 3.480635432438152e-08 0.041535417676099584 0.013845130148068272 1.2137835518967627e-10 9.91585875197397 -0.5182944887308166 GISIK(ub)LQEEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GISIKLQEEER 11 1 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 1 8117900.0 713100.0 1521700.0 5883100.0 True False 934881.0056702239 1294668.291540142 5274373.2466800595 1.0 1.3848482145724885 5.641758913369748 19.83442322076919 -6.9246023077741485 0.7898326051135847 0.9207164245258201 6.406588147920961 0.9953669498954688 0.14316516665611317 0.09553912852607205 0.09212928794922923 0.12646003984775656 0.3972202628365483 1.1895910613810744e-07 6.9246023077741485 5.485871723395141 up GISIK(ub)LQEEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GISIKLQEEER 11 1 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 1 13303900.0 2899500.0 7359800.0 3044600.0 True False 2807456.959606056 10298606.520849962 2247127.923957832 1.0 3.6683043298712112 0.8004140246100693 21.420832474536383 -6.662407252550369 1.9646109647970664 2.7141776488559475 0.812383480355557 0.24577009450441412 1.1354604013012337 0.47876796872580296 3.554885869003425 0.4665626677380581 1.258864713546257 2.1756686177955158e-07 6.662407252550369 -1.9017941685003905 GISIK(ub)LQEEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GISIKLQEEER 11 1 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 1 64800100.0 2247100.0 10973000.0 51580000.0 True False 3409014.985015104 9014782.417559683 41385190.391682915 1.0 2.6443950693046725 12.139926217279315 21.70092351047392 -6.936650895708406 0.6900148416866001 0.8847622232668373 14.466556904931636 0.9976915371027706 0.2359049966539784 0.0893282544239214 0.061819200098145774 0.2241793814977003 0.8300346385926908 1.1570419477778277e-07 6.936650895708406 13.5817946816648 GISIK(ub)LQEEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GISIKLQEEER 11 1 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 1 14069200.0 713100.0 5300300.0 8055800.0 True False 976752.340802903 5066115.220251779 6153185.954408888 1.0 5.186693707933546 6.299637786740178 19.89763328229208 -9.335206356010847 0.43186809029587464 1.0243126360885734e-16 6.401620294946305 0.9979764398794496 0.10263759640202624 0.7007006412448487 0.1745013349834068 1.450692124087331 0.2586917353294147 4.621613721928336e-10 9.335206356010847 6.401620294946305 GISIK(ub)LQEEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GISIKLQEEER 11 1 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 1 17379600.0 2899500.0 12651100.0 1829000.0 True False 2411062.7196293264 12582946.013253251 2211435.443659487 1.0 5.2188381126757815 0.9172036155075511 21.20123774997066 -6.650541257642256 2.0063305830766405 3.7362341962057264 0.9350453862169769 0.19658354819739976 1.8003597596369667 0.5070226204402596 3.912572999578293 0.7275526030899597 1.9945370608666835 2.2359327767360584e-07 6.650541257642256 -2.8011888099887496 GISIK(ub)LQEEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GISIKLQEEER 11 1 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 1 45997400.0 2247100.0 16507600.0 27242700.0 True False 2908915.2469631224 15588937.548653353 22284808.133707315 1.0 5.359020880697038 7.660865388557617 21.47204983256637 -8.577866425790841 0.3479435731344654 7.016523262940019e-23 8.47868647142823 0.9979501101199476 0.12505959907047084 0.2167315842318158 0.10568084157354579 0.9011808456836464 0.6486904183532826 2.6432215973629643e-09 8.577866425790841 8.47868647142823 GISNMLDVNGLFTLSHITQLVLSHNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GISNMLDVNGLFTLSHITQLVLSHNK 26 0 Q15404 Q15404 RSU1 Ras suppressor protein 1 0 4977890000.0 1859900000.0 1592080000.0 1525910000.0 False True 2821604276.903378 1307960885.0221827 1224313219.669888 1.0 0.46355220529280905 0.4339067776766816 31.393868521658717 -13.906055650439612 0.4130798565872966 9.999999999999579 0.4326656797969456 0.9998541108180731 0.0031422431132379193 26.523956367886967 0.21323883584467576 214.36007125573985 0.007325957256424617 1.24149321261724e-14 13.906055650439612 -9.567334320202633 GISNMLDVNGLFTLSHITQLVLSHNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GISNMLDVNGLFTLSHITQLVLSHNK 26 0 Q15404 Q15404 RSU1 Ras suppressor protein 1 0 4697040000.0 1859900000.0 1624380000.0 1212760000.0 False True 2407677214.1100535 1533981825.0552204 992050123.9684346 1.0 0.6371210459879789 0.4120361808279706 31.164994843751167 -8.805677250088676 0.14553944423976517 1.478941041647095 2.378856085137748e-10 0.9998811285497355 0.0026409019553215746 0.3269557972254152 0.0426588649575459 0.23156611900684537 0.1646042747412558 1.5643097418491156e-09 8.805677250088676 -1.4789410414092092 GISTK(ub)PVYIPEVELNHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GISTKPVYIPEVELNHK 17 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 11168800.0 4143200.0 3604600.0 3421000.0 True False 5431775.322805878 3066807.7306207498 3067027.7365491814 1.0 0.5646050413286493 0.5646455448317135 22.372992375236446 -9.892588389647177 5.699514764615644 1.0000002123987213 0.5646252930944747 0.9999999927175285 1.6535488787476738e-05 22547.517043292642 0.003697441100700176 0.06286596089158046 5.660537181625889e-06 1.28059443543414e-10 9.892588389647177 -0.43537491930424654 GISTK(ub)PVYIPEVELNHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GISTKPVYIPEVELNHK 17 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 13740700.0 5097500.0 3175700.0 5467500.0 True False 4935682.652730425 4443773.571056717 4035397.7285158713 1.0 0.9003361609155355 0.8175966755649262 22.23481820650795 -6.973263262144997 0.16229130447369056 1.0811553531323523 0.634577577271285 0.9999979312596713 0.00010710316099015528 0.07525733806479509 0.005021486044650899 0.0037469414208739647 0.009846181994972204 1.0634981477696697e-07 6.973263262144997 -0.4465777758610673 GISTK(ub)PVYIPEVELNHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GISTKPVYIPEVELNHK 17 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 11184100.0 4143200.0 3804300.0 3236600.0 True False 5675053.005770002 3636213.4468622236 2472181.73986939 1.0 0.6407364729748204 0.4356226694897557 22.436202436759338 -9.910354182627358 0.12059625378927417 1.7384870459030937 2.31146314729118e-12 0.9998746883471106 0.0026110932327397065 1.4622846685840603 0.0545339291091282 0.5719675631084477 0.23373410816568516 1.2292658517992085e-10 9.910354182627358 -1.7384870459007822 GISTK(ub)PVYIPEVELNHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GISTKPVYIPEVELNHK 17 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 18416400.0 5097500.0 6381800.0 6937100.0 True False 4238797.1075393995 6347419.97671188 8387615.536473611 1.0 1.497457843741081 1.9787725912983318 22.015223481942225 -6.971528324449809 0.21862229858618373 0.7741411890288393 2.715658541799631 0.9999919750363065 0.0011319878164232334 0.07580983842353683 0.007228999623396811 0.01347375524433368 0.04892712286703682 1.0677551518581226e-07 6.971528324449809 1.9415173527707914 GISTKPVYIPEVELNHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GISTKPVYIPEVELNHK 17 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 0 8466000.0 1400100.0 3464700.0 3601200.0 False True 1835544.6585876858 2947780.2652948205 3228582.36914964 1.0 1.6059430924240856 1.7589233550077679 20.807776784790896 -11.325376248925537 0.24928837156537456 9.532200878299044e-10 1.8310634762920759 0.9992838948040222 0.008769519090614629 3.5961924265956484 0.13737492681239236 2.0467123780157834 0.07046881857883432 4.727415241664339e-12 11.325376248925537 1.8310634753388557 GISTKPVYIPEVELNHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GISTKPVYIPEVELNHK 17 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 0 6932700.0 1400100.0 2537300.0 2995300.0 False True 1917754.8062798243 2425193.696270938 2287871.8301398936 1.0 1.2646005048870006 1.19299496611772 20.870986846313787 -10.055185722993881 4.400491706251037 0.9999844917178505 1.2287977354942072 0.9315670602642117 0.02923283887569103 20258294.184524886 0.11053171607997292 3266.810402199225 0.01000717828240896 8.806721791783161e-11 10.055185722993881 0.2288132437763567 GISVHISNAEPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GISVHISNAEPK 12 0 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A1W2PNU8;A0A087WZC9;A0A087WYE7;K7EL26;A0A087WTZ4 Q13148 TARDBP TAR DNA-binding protein 43 0 155518000.0 63229000.0 41769000.0 50520000.0 False True 82893831.31050706 35537228.01428677 45292675.02205925 1.0 0.42870775125799154 0.5463937943994905 26.304761409251388 -10.123627611783762 7.1114815232364945 1.000000300154455 0.487550772828741 0.9619493809714811 0.04804512592397355 2.2863139164573223e-07 2.8170422457413653e-08 0.04651952086914396 0.015506497714165627 7.522676536311864e-11 10.123627611783762 -0.5124495273257141 GISVHISNAEPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GISVHISNAEPK 12 0 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A1W2PNU8;A0A087WZC9;A0A087WYE7;K7EL26;A0A087WTZ4 Q13148 TARDBP TAR DNA-binding protein 43 0 118859100.0 35825000.0 19251100.0 63783000.0 False True 34687754.984613545 26938164.623160236 47076318.851015665 1.0 0.7765900282422199 1.357145161798373 25.04792313564086 -6.802387284706711 1.446209247298408 0.8771060189923894 1.3656339249466427 0.8390356187284003 0.0959268319357803 0.21736704245944233 0.8972917965986702 0.052176228251032845 0.12116709058901594 1.576205052490389e-07 6.802387284706711 0.4885279059542533 GISVHISNAEPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GISVHISNAEPK 12 0 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A1W2PNU8;A0A087WZC9;A0A087WYE7;K7EL26;A0A087WTZ4 Q13148 TARDBP TAR DNA-binding protein 43 0 250764000.0 62622000.0 93320000.0 94822000.0 False True 95002152.28143638 76666316.887512 76080390.13804106 1.0 0.8069955790095584 0.8008280687437366 26.501456862398086 GISVHISNAEPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GISVHISNAEPK 12 0 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A1W2PNU8;A0A087WZC9;A0A087WYE7;K7EL26;A0A087WTZ4 Q13148 TARDBP TAR DNA-binding protein 43 0 155724000.0 63229000.0 36901000.0 55594000.0 False True 86606469.99947658 35270591.80471121 42463842.19437031 1.0 0.4072512342891284 0.4903079665367604 26.36797147077428 -10.697732234312847 6.799809250223106 1.0048524618229848 0.44877960041335774 0.9832572212491976 0.033907768951610566 0.002501863359868626 0.00011121372135613437 0.03292975545478573 0.010943685371386387 2.005708272233861e-11 10.697732234312847 -0.5560728614096271 GISVHISNAEPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GISVHISNAEPK 12 0 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A1W2PNU8;A0A087WZC9;A0A087WYE7;K7EL26;A0A087WTZ4 Q13148 TARDBP TAR DNA-binding protein 43 0 69256200.0 35825000.0 11446000.0 21985200.0 False True 29790074.81659618 11384338.126146873 26582203.671920486 1.0 0.38215204883623216 0.89231745256012 24.828328411075137 -10.169538757657786 7.637644989680805 1.0000001647621795 0.6372347506981986 0.40268835179931206 0.2082741539240837 5.841803337984239e-07 6.373779920937378e-08 0.20166067254597492 0.06722019413278472 6.768013905699868e-11 10.169538757657786 -0.3627654140639809 GISVHISNAEPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GISVHISNAEPK 12 0 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A1W2PNU8;A0A087WZC9;A0A087WYE7;K7EL26;A0A087WTZ4 Q13148 TARDBP TAR DNA-binding protein 43 0 282718000.0 62622000.0 133857000.0 86239000.0 False True 81065413.46416472 126407740.28024015 70544386.88686442 1.0 1.5593301122940573 0.8702155934608148 26.272583184490536 -6.690822711068688 1.8636333231662872 1.3503944767904974 0.8725817979925009 0.3742445518307357 0.2365177770642217 0.4148865042169528 2.79443139618729 0.10150737024820768 0.2640447460759413 2.0378738145844957e-07 6.690822711068688 -0.4778126787979965 GISVHISNAEPK(ub)HNSNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GISVHISNAEPKHNSNR 17 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A1W2PNU8;A0A087WZC9;A0A087WYE7;K7EL26;A0A087WTZ4 Q13148 TARDBP TAR DNA-binding protein 43 1 7517800.0 2044100.0 2655700.0 2818000.0 True False 2679834.8950925614 2259479.91183752 2526420.392164747 1.0 0.8431414621755934 0.9427522556674093 21.353712688153237 -10.385001905801456 5.156308404429507 1.0000721899828864 0.8929468589258238 0.6063014313605324 0.04066593615480476 3.377095132258633e-05 4.02789754616294e-06 0.039401146915305496 0.013124874457121244 4.1209571070610855e-11 10.385001905801456 -0.10712533105706257 GISVHISNAEPK(ub)HNSNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GISVHISNAEPKHNSNR 17 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A1W2PNU8;A0A087WZC9;A0A087WYE7;K7EL26;A0A087WTZ4 Q13148 TARDBP TAR DNA-binding protein 43 1 10946900.0 1614600.0 3326300.0 6006000.0 True False 1563345.4067873585 4654508.936425348 4432848.423862155 1.0 2.9772748339666437 2.8354888207152915 20.576205133078204 -10.348501680162135 5.53338278071109 0.9995266086644818 2.90638182734099 0.9958684762239975 0.05788389752162985 0.00033811332117292123 3.980937816271774e-05 0.056057692384271066 0.018681947592892705 4.4822731592894893e-11 10.348501680162135 1.9068552186765082 GISVHISNAEPK(ub)HNSNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GISVHISNAEPKHNSNR 17 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A1W2PNU8;A0A087WZC9;A0A087WYE7;K7EL26;A0A087WTZ4 Q13148 TARDBP TAR DNA-binding protein 43 1 49154000.0 4783700.0 9901300.0 34469000.0 True False 7257222.635315178 8134335.6557899965 27656187.041700628 1.0 1.1208607017520176 3.8108500223101576 22.79098609869048 -6.916302675987004 0.8516984472965686 0.9323747215655432 4.20977385617029 0.9930905965129712 0.10785175939385987 0.10039674909852099 0.11724881874467812 0.09114942426636874 0.2640885837552556 1.2125434892340623e-07 6.916302675987004 3.2773991346047473 up GISVHISNAEPK(ub)HNSNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GISVHISNAEPKHNSNR 17 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A1W2PNU8;A0A087WZC9;A0A087WYE7;K7EL26;A0A087WTZ4 Q13148 TARDBP TAR DNA-binding protein 43 1 6144700.0 2044100.0 2442900.0 1657700.0 True False 2799859.0097254454 2334964.6004099906 1266185.4014031647 1.0 0.8339579215593994 0.4522318434624774 21.41692274967613 -6.957232064915457 0.47283286289401305 1.0098098152032466 0.2606562170734884 0.9996533598392328 0.004269745306854733 0.08070512649264235 0.024900285265973342 0.00530648949775819 0.031500020628232865 1.1034888139535043e-07 6.957232064915457 -0.7491535981297582 down GISVHISNAEPK(ub)HNSNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GISVHISNAEPKHNSNR 17 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A1W2PNU8;A0A087WZC9;A0A087WYE7;K7EL26;A0A087WTZ4 Q13148 TARDBP TAR DNA-binding protein 43 1 6945500.0 1614600.0 3505100.0 1825800.0 True False 1342611.438907921 3486217.33059212 2207566.3384546116 1.0 2.59659439027855 1.6442332267407493 20.35661040851248 -10.354405525719885 7.34969516166529 0.9999798416109235 2.1204138085096496 0.648556493168341 0.3887998169184826 0.00012842872290395586 1.1281126847122364e-05 0.37646053074651864 0.1254846013278147 4.421752950475373e-11 10.354405525719885 1.1204339668987262 GISVHISNAEPK(ub)HNSNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GISVHISNAEPKHNSNR 17 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A1W2PNU8;A0A087WZC9;A0A087WYE7;K7EL26;A0A087WTZ4 Q13148 TARDBP TAR DNA-binding protein 43 1 57266200.0 4783700.0 9428500.0 43054000.0 True False 6192593.950824385 8903795.686682403 35218613.77134546 1.0 1.437813581414795 5.687215091287716 22.56211242078293 -6.9266873023957185 0.7734967603836232 0.926825177428365 6.490303822988111 0.9958461765183462 0.13624445164767174 0.09439498266894183 0.08637617950612096 0.12176091630061132 0.39173517006383396 1.1838936675671048e-07 6.9266873023957185 5.563478645559746 up GITEQQK(ub)EGLEIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GITEQQKEGLEIVK 14 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 11227300.0 3480600.0 4104800.0 3641900.0 True False 4563100.306178349 3492379.8403850785 3265071.1235716036 1.0 0.7653524152551422 0.7155378809338819 22.121582936812658 -13.999999999999998 0.21781755286285018 2.4025681643429757 0.6883282914429112 0.9994958006648181 0.0027850987565101715 12.941146665185682 0.1478675322285706 7.798349338375097 0.02797083951471604 1.0000000000000041e-14 13.999999999999998 -1.7142398729000645 GITEQQK(ub)EGLEIVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GITEQQKEGLEIVK 14 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 43723900.0 5347100.0 9741800.0 28635000.0 True False 8111941.625372366 8003299.676969184 22975279.698833663 1.0 0.9866071585052616 2.832278726830584 22.9516158398744 -6.905266053472211 0.9273877813872764 0.933952066578704 3.0481291049073285 0.9890087023266675 0.09088720018704838 0.10763180339516998 0.1563706489402507 0.07271104051190073 0.19470085455879083 1.2437524422108895e-07 6.905266053472211 2.1141770383286245 up GITEQQK(ub)EGLEIVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GITEQQKEGLEIVK 14 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 7578700.0 2259500.0 5319200.0 0.0 True False 1878874.3628220246 5290544.413821465 0.0 1.0 2.81580531328087 0.0 20.84143716870927 -6.732579387059747 1.7136651605652655 2.08958661480062 0.0008217732942641088 0.5712389244523085 0.7631800193194439 0.3314308901559131 1.9078879130104336 0.35274317771562597 0.8728173160991152 1.8510604978217167e-07 6.732579387059747 -2.088764841506356 GITEQQK(ub)EGLEIVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GITEQQKEGLEIVK 14 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 57215100.0 5347100.0 10007000.0 41861000.0 True False 6921926.357098703 9450101.653140014 34242727.53013173 1.0 1.3652415766383543 4.946993909435989 22.72274216196685 -6.926516673972404 0.7748500348736858 0.9379244022901831 5.621073534000961 0.9958082125252168 0.11529588791689195 0.09448743678931384 0.08683965950518674 0.10293976201215199 0.33051164927688387 1.1843588947486138e-07 6.926516673972404 4.683149131710778 up GITFDSGGISIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GITFDSGGISIK 12 0 P28838-2;P28838;H0Y9Q1 P28838-2 LAP3 Cytosol aminopeptidase 0 41991000.0 13021000.0 11805000.0 17165000.0 False True 17070657.09554337 10043740.01552959 15388930.458306534 1.0 0.588362823956654 0.9014843642031868 24.02501525686168 -9.763728948999757 5.926792596433397 1.0000000120101427 0.7449235940788883 0.46944449444628067 0.12783133351672593 2.0400986194364032e-08 4.0454491109557525e-09 0.12377216383422454 0.041257385485610754 1.7229435595682633e-10 9.763728948999757 -0.25507641793125435 GITGVEDK(ub)ESWHGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GITGVEDKESWHGK 14 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 3393040.0 740940.0 1377000.0 1275100.0 True False 717419.26527005 1926843.280960138 941113.0578199526 1.0 2.68579807406599 1.3118034368169638 19.4524569617679 -6.595497426698877 2.207831351034185 2.1370340585708436 1.3160607490567076 0.007779179195248287 0.7294935619330557 0.6536275946079326 6.014636155612788 0.274962292694128 0.8121473183227712 2.538064024569904e-07 6.595497426698877 -0.820973309514136 GITGVEDK(ub)ESWHGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GITGVEDKESWHGK 14 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 7789800.0 3242200.0 2243500.0 2304100.0 True False 4197091.813316643 2118647.2528050016 1884777.442062459 1.0 0.5047893510651594 0.449067479553911 22.000958592511733 -13.999999999999998 0.3083975922713209 5.742268475725011 0.43651434676173445 0.9996684681848974 0.004508763773861288 17.156412665225847 0.176638212311537 52.162716659135455 0.019437239549519106 1.0000000000000041e-14 13.999999999999998 -5.305754128963276 GITGVEDK(ub)ESWHGK(ub)PLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GITGVEDKESWHGKPLPK 18 2 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 2 27904200.0 9541400.0 11548900.0 6813900.0 True False 12508867.799049033 9825849.137259621 6108862.991544131 1.0 0.7855106709183237 0.4883625832234431 23.576447878605997 -6.9665446180930575 0.330471358155955 1.03600370957061 0.22813514183628383 0.9999415347624511 0.0016040347903803676 0.07744064773083642 0.013032607418943777 0.004328609076674993 0.025908092245699448 1.0800786511888321e-07 6.9665446180930575 -0.8078685677343262 down GITGVEDK(ub)ESWHGK(ub)PLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GITGVEDKESWHGKPLPK 18 2 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 2 33242600.0 10523000.0 12477600.0 10242000.0 True False 10188953.124998985 17459970.74982439 7559312.946586123 1.0 1.71361773242294 0.741912623784583 23.280502492068596 -6.709885671616192 1.7956479412648745 1.438763996079188 0.744203977617093 0.4645722585273364 0.30071909062335567 0.3752896318013034 2.358755489550115 0.1332770111431968 0.3386286896098862 1.9503579655407345e-07 6.709885671616192 -0.694560018462095 GITGVEDK(ub)ESWHGK(ub)PLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GITGVEDKESWHGKPLPK 18 2 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 2 114689400.0 42207400.0 22157000.0 50325000.0 True False 64031711.57426306 18202910.236568835 40378241.69176893 1.0 0.2842796137888234 0.630597569533009 25.932283238077737 -10.61586854885766 6.60500005689601 1.0015749277783688 0.4574385916622924 0.7659478294985188 0.14138371338950356 0.0032865768911905743 0.00019113945228728607 0.1372126389182067 0.045631397281875825 2.4217619485229893e-11 10.61586854885766 -0.5441363361160764 GITGVEDK(ub)ESWHGK(ub)PLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GITGVEDKESWHGKPLPK 18 2 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 2 28010200.0 9541400.0 9406600.0 9062200.0 True False 13069113.426639754 8990985.308533555 6921895.001867513 1.0 0.6879567890356323 0.529637686651192 23.639657940128888 -13.999999999596872 0.08736701723438672 2.6170703008436145 0.11513724112398728 0.9998545909703787 0.002356395136071093 12.187786046622053 0.08522634708342192 3.6948321715044865 0.3733509942119815 1.000000000928237e-14 13.999999999596872 -2.501933059719627 GITGVEDK(ub)ESWHGK(ub)PLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GITGVEDKESWHGKPLPK 18 2 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 2 35750300.0 10523000.0 20873500.0 4353800.0 True False 8750340.74794255 20761050.312434655 5264159.450303268 1.0 2.3725990690495293 0.6015947952130914 23.060907767502872 -6.699775407705862 1.831501306425151 1.8524984326583196 0.6068525153796276 0.41661621738611154 0.5794123203624537 0.395975292613467 2.58213055096558 0.25239088614980426 0.6493035248244995 1.9962944174950492e-07 6.699775407705862 -1.245645917278692 GITGVEDK(ub)ESWHGKPLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GITGVEDKESWHGKPLPK 18 2 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 92719800.0 30345100.0 42153200.0 20221500.0 True False 39782719.96236645 35864106.87188667 18129173.158324845 1.0 0.9014996185734234 0.455704717411847 25.245638581460845 -6.942050047843239 0.6402086448407678 1.004880931304985 0.3278736018675437 0.9984202645177976 0.00941205363518278 0.08684374005525142 0.05044342707355257 0.009311049785520406 0.038035612060476134 1.1427466377443705e-07 6.942050047843239 -0.6770073294374412 down GITGVEDK(ub)ESWHGKPLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GITGVEDKESWHGKPLPK 18 2 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 156317100.0 55996400.0 43814700.0 56506000.0 True False 54218824.93287972 61310138.200641975 41705383.45633618 1.0 1.1307906114996213 0.769204856578235 25.692290510661277 -6.8088363737296635 1.419266297791965 1.0713786754946109 0.7630366524439561 0.8568079221608558 0.0565669102477616 0.20838945214144128 0.8275089311735945 0.03134026839248447 0.0725406003947758 1.5529720027780142e-07 6.8088363737296635 -0.3083420230506547 GITGVEDK(ub)ESWHGKPLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GITGVEDKESWHGKPLPK 18 2 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 670349000.0 295078000.0 30673000.0 344598000.0 True False 447654899.0914001 25199163.500757143 276488054.25733095 1.0 0.05629149497057575 0.6176366098494969 28.737811734175768 -9.990189455420884 6.1925463449629135 1.0000003700315114 0.3369640541604193 0.6503706185770168 0.22916818350968862 1.1708015542138532e-06 1.906160712160532e-07 0.22189126519159164 0.07396371318445026 1.0228466911361219e-10 9.990189455420884 -0.6630363158710921 GITGVEDK(ub)ESWHGKPLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GITGVEDKESWHGKPLPK 18 2 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 95655500.0 30345100.0 45784700.0 19525700.0 True False 41564503.51549316 43761780.56424381 14914131.80441442 1.0 1.0528642678946378 0.35881895711457684 25.308848642983737 -6.88852723813267 1.031078196648806 1.0386192840444815 0.3008239738733399 0.9799379503699697 0.04468122256282813 0.12034528733312873 0.22890406532548133 0.033081266741086794 0.08204504709948635 1.2926256272174622e-07 6.88852723813267 -0.7377953101711415 down GITGVEDK(ub)ESWHGKPLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GITGVEDKESWHGKPLPK 18 2 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 145092400.0 55996400.0 74524000.0 14572000.0 True False 46563487.661131844 74122524.42014411 17618937.826684523 1.0 1.5918593761613082 0.3783852694821153 25.472695786095553 -6.774079085986485 1.5588454997650305 1.3377014236177465 0.37048267219860737 0.7459193912159661 0.24973773357686543 0.25988200892812213 1.246831225996114 0.1262382298055224 0.29938854795942876 1.6823676702973372e-07 6.774079085986485 -0.967218751419139 down GITGVEDK(ub)ESWHGKPLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GITGVEDKESWHGKPLPK 18 2 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 617742000.0 295078000.0 154070000.0 168594000.0 True False 381984287.8569635 145495869.06158525 137911621.9205237 1.0 0.38089490507019785 0.3610400383069306 28.508938056268217 GITIDISLWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GITIDISLWK 10 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 4164786200.0 1219544000.0 1527405200.0 1417837000.0 False True 1850137408.6089876 1254827808.3887036 1137600895.4899676 1.0 0.6782349259843012 0.6148737332678791 30.784985276812737 -13.999999999999998 0.22845752100744599 3.016815375328588 0.5836113419025925 0.9995077257051007 0.003741030000617263 13.243741237446404 0.15135249863399902 12.105568241886822 0.03320872540211494 1.0000000000000041e-14 13.999999999999998 -2.4332040334259957 GITIDISLWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GITIDISLWK 10 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 2548262000.0 1219544000.0 325743000.0 1002975000.0 False True 1578723748.8061905 307615115.69889015 820443841.3925586 1.0 0.1948505024590303 0.5196880340927076 30.556111598905186 -10.539171626194939 6.290296884699168 1.0008114874015646 0.3572692683051155 0.8392264196869679 0.1326143669679498 0.00151089062130922 0.00011068795956319772 0.1285475827130934 0.04280110289455906 2.889537757853264e-11 10.539171626194939 -0.643542219096449 GITIDISLWKFETTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GITIDISLWKFETTK 15 1 A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 A0A2U3TZH3 EEF1A2 Elongation factor 1-alpha 2 0 343451000.0 79040000.0 130137000.0 134274000.0 False True 119909458.59801236 106913035.58497815 107734685.04561524 1.0 0.8916146969139127 0.8984669458544371 26.837370223807923 -10.133984337976555 7.091477527151827 1.0000000758035978 0.8950408213843134 0.996813583964353 0.0027974189158019424 3.35348027003958e-09 4.097883982524764e-10 0.0027085911960088604 0.0009028630727721992 7.345403575124724e-11 10.133984337976555 -0.10495925441928444 GITIDISLWKFETTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GITIDISLWKFETTK 15 1 A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 A0A2U3TZH3 EEF1A2 Elongation factor 1-alpha 2 0 181721200.0 79040000.0 42353200.0 60328000.0 False True 102318838.11132792 39996207.188544996 49348923.01755305 1.0 0.3908977850689348 0.48230534990887014 26.608496545900373 -10.769615833397374 7.096387021144095 1.0130593158150043 0.43660156748890244 0.9806400640642652 0.03731698208136831 0.007545216509999703 0.0002449551203099842 0.035358819630650976 0.012044004177655006 1.6997465431482236e-11 10.769615833397374 -0.5764577483261019 GITINAAHVEYSTAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GITINAAHVEYSTAAR 16 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 189221600.0 50237600.0 63188000.0 75796000.0 False True 65861980.10161037 53760596.70489483 67953357.00657168 1.0 0.8162614701524947 1.0317539330237988 25.972942550572842 -6.680889692324547 1.8982421821736974 0.8838342064107247 1.0309458892645162 0.3281457065466922 0.07785887238559222 0.4367088235350275 3.0430387021533476 0.0328985302979615 0.08668427223234043 2.0850203960357096e-07 6.680889692324547 0.1471116828537915 GITINAAHVEYSTAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GITINAAHVEYSTAAR 16 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 114214700.0 37007900.0 19335900.0 57870900.0 False True 35833104.47160031 27056825.70538644 42712775.20021385 1.0 0.7550790282999469 1.1919920372533186 25.094789703902013 -6.75460547626977 1.6329456512887017 0.856784567618846 1.1931671583751244 0.6684951821914256 0.10294942830019366 0.2920763504546905 1.5336661965306448 0.04977656751078776 0.12025870100522555 1.759521280338268e-07 6.75460547626977 0.3363825907562784 GITINAAHVEYSTAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GITINAAHVEYSTAAR 16 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 121354100.0 32957200.0 78488000.0 9908900.0 False True 49998481.89405884 64481203.17045699 7950401.571774842 1.0 1.289663220317077 0.15901285940282844 25.575380955155648 -6.838735402062434 1.2882308960209972 1.1541283246769796 0.12273908237438913 0.9222658709844391 0.13369677675654024 0.17027715002084792 0.5494598985840277 0.08139610358573213 0.18746467992574897 1.4496548001662278e-07 6.838735402062434 -1.0313892423025903 down GITINAAHVEYSTAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GITINAAHVEYSTAAR 16 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 177649300.0 50237600.0 53273700.0 74138000.0 False True 68811798.34009232 50919891.78143257 56628131.32003846 1.0 0.7399878074653478 0.8229421797721685 26.036152612095734 -10.412922473383029 8.35725073721804 1.0000027112335057 0.7814649936187582 0.9024715486526371 0.03386598068076241 1.71080448093353e-06 1.2020979462231332e-07 0.032791001239538514 0.010930198264964573 3.86435954210335e-11 10.412922473383029 -0.2185377176147475 GITINAAHVEYSTAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GITINAAHVEYSTAAR 16 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 86465000.0 37007900.0 25308900.0 24148200.0 False True 30773708.57795146 25172555.932276674 29197476.97133843 1.0 0.8179890268510613 0.948779926780019 24.87519497933629 -10.282942275879954 5.476550324514738 1.0000137959979207 0.8833844768356764 0.5145576659742626 0.05339516130424211 8.995293889459216e-06 1.1777543133880204e-06 0.051705757026138506 0.017233214208280195 5.2126399014687484e-11 10.282942275879954 -0.11662931916224428 GITINAAHVEYSTAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GITINAAHVEYSTAAR 16 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 108690200.0 32957200.0 68068000.0 7665000.0 False True 42663745.08353561 64279955.96341916 6270048.6495415745 1.0 1.5066646361579137 0.1469643285479233 25.346507277248097 -6.805788016758277 1.432064012506847 1.2775363555400177 0.12537977606225748 0.8485637117195004 0.21833812088481308 0.21260471103013245 0.8600721245472295 0.11990764412671394 0.27795034770635857 1.5639108160216728e-07 6.805788016758277 -1.1521565794777602 down GITLVCLK(ub)CDFLADSSGLDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GITLVCLKCDFLADSSGLDR 20 1 Q8ND82 Q8ND82 ZNF280C Zinc finger protein 280C 1 34410000.0 11784000.0 0.0 22626000.0 True False 17877189.525796797 0.0 18153961.182671927 1.0 0.0 1.015481832671503 24.091616612371734 -12.069358026351996 18.158719315864904 0.8827827020047849 0.5569668247021875 0.0 0.4887829957375089 0.0 0.0 0.0 0.14052522002950668 8.523971199158155e-13 12.069358026351996 -0.3258158773025974 GITLVCLK(ub)CDFLADSSGLDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GITLVCLKCDFLADSSGLDR 20 1 Q8ND82 Q8ND82 ZNF280C Zinc finger protein 280C 1 29373200.0 11784000.0 6814200.0 10775000.0 True False 15254620.297367021 6434983.779836788 8814060.560836343 1.0 0.42183834499948053 0.5777961292394586 23.862742934464183 -10.542466173821438 9.610092843759714 1.0000200533148411 0.4998172371196259 0.9320401285856539 0.06366949880050303 2.735675612430841e-05 1.3024615392662599e-06 0.061650186571530055 0.020549242376310096 2.8677007253664408e-11 10.542466173821438 -0.5002028161952152 GIVDQSQQAYQEAFEISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIVDQSQQAYQEAFEISK 18 0 P63104;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 0 22354600.0 2048700.0 13153000.0 7152900.0 False True 2685865.53963902 11190623.669992428 6412786.5234617535 1.0 4.166486931246919 2.3876051979592514 21.35695565139721 -9.810480867868984 6.2844024343661875 0.999999924124997 3.277046064604174 0.6859969004979474 0.7262254265559787 7.77532073429713e-07 1.4672222737131996e-07 0.7031647666142549 0.2343882485530672 1.547102657516538e-10 9.810480867868984 2.277046140479177 GIVDQSQQAYQEAFEISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIVDQSQQAYQEAFEISK 18 0 P63104;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 0 44832600.0 14294000.0 5092600.0 25446000.0 False True 13840244.794140033 7126101.737558162 18780929.236363046 1.0 0.5148826370885692 1.3569795560491027 23.7223661245394 -6.750507168461951 1.648191140284624 0.7149195780425309 1.3586963919672816 0.651081392563643 0.20385343936044947 0.2991504815341467 1.599087172072923 0.09770286138137009 0.23704917727386823 1.7762039500353943e-07 6.750507168461951 0.6437768139247507 GIVDQSQQAYQEAFEISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIVDQSQQAYQEAFEISK 18 0 P63104;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 0 27616700.0 2048700.0 10020000.0 15548000.0 False True 2806159.7540357662 9577283.268291015 11875882.621111415 1.0 3.4129501196491563 4.2320764539623035 21.420165712920102 -9.410335184556388 0.33541718113997376 4.471945186614806e-22 4.469466020220606 0.9984540108850334 0.05394282902588859 0.7843299363667796 0.1330292130893201 1.1775000143034855 0.2510521852124115 3.8874499930696144e-10 9.410335184556388 4.469466020220606 GIVDQSQQAYQEAFEISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIVDQSQQAYQEAFEISK 18 0 P63104;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 0 21459600.0 14294000.0 3379800.0 3785800.0 False True 11886094.33156808 3361592.3465622226 4577393.276438531 1.0 0.2828172360734363 0.3851049090432934 23.502771399973675 -10.487948839282325 6.503226204445059 1.0003115409116137 0.3339610725583648 0.9826182511779749 0.04175876762547089 0.00018870656193389698 1.485834696188732e-05 0.04045077985057401 0.013477584297632841 3.251255955443929e-11 10.487948839282325 -0.6663504683532488 GIVDQSQQAYQEAFEISKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIVDQSQQAYQEAFEISKK 19 1 P63104;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 1 5819200.0 2099000.0 1685700.0 2034500.0 True False 2751809.3267449113 1434200.1308071367 1823989.4563020496 1.0 0.5211844137848163 0.6628327909839702 21.391949078285112 -10.686739416345363 10.123059284682615 1.0002751031393073 0.5920086023844002 0.9170921876232416 0.05782770783853501 0.00035926944031318105 1.1117663227404108e-05 0.05602688657389765 0.018663812450666187 2.0571245334695533e-11 10.686739416345363 -0.4082665007549071 GIVDQSQQAYQEAFEISKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIVDQSQQAYQEAFEISKK 19 1 P63104;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 1 15410200.0 4771300.0 4730000.0 5908900.0 True False 4619837.693177577 6618713.666624137 4361181.826799718 1.0 1.4326723374716028 0.9440119147995537 22.139410736255318 -6.672966979480188 1.9263294910082671 1.2754499620193436 0.945933870229807 0.29255295344130605 0.18366214814070547 0.4542979101825913 3.2526468481289097 0.07667047501685492 0.20409423397339663 2.1234059038424655e-07 6.672966979480188 -0.32951609178953656 GIVDQSQQAYQEAFEISKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIVDQSQQAYQEAFEISKK 19 1 P63104;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 1 41348200.0 5762200.0 14040000.0 21546000.0 True False 8741678.673247298 11534452.304979322 17287423.65605271 1.0 1.3194779556790301 1.9775862625743135 23.05947891781694 -6.959463610892752 0.4429363498920761 0.9771764110044926 2.3456716417582393 0.9997497634972368 0.0064382899022595525 0.07989339728075472 0.021844248836857406 0.008709438603929554 0.0544989803552204 1.0978332727896434e-07 6.959463610892752 1.3684952307537466 GIVDQSQQAYQEAFEISKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIVDQSQQAYQEAFEISKK 19 1 P63104;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 1 8449500.0 2099000.0 2857800.0 3492700.0 True False 2875057.0233421535 2731532.9465191686 2667796.1944144503 1.0 0.9500795721066627 0.9279107067286027 21.455159139808003 -13.999998952037824 0.10997441021967605 1.2408818101143202 0.8872277681939752 0.999743156161531 0.0004831354438749627 12.01273067419714 0.10062681907909007 0.6425369280377514 0.036134917864533336 1.0000024130249951e-14 13.999998952037824 -0.353654041920345 GIVDQSQQAYQEAFEISKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIVDQSQQAYQEAFEISKK 19 1 P63104;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 1 16803100.0 4771300.0 4819700.0 7212100.0 True False 3967547.3544291817 4793735.319464456 8720116.765017256 1.0 1.2082364471624913 2.1978607905668803 21.919816011689594 -6.940945284811644 0.6507199739883333 0.9890474920468119 2.4723104563869125 0.9982849938187112 0.02164044676430607 0.08733821352656898 0.05266761424211599 0.021219268608329282 0.08482659857479079 1.1456572695624119e-07 6.940945284811644 1.4832629643401005 up GIVEFASK(ub)PAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIVEFASKPAAR 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 7734200.0 1349400.0 4779900.0 1604900.0 True False 1769076.4676081885 4066757.5519042714 1438840.3432878656 1.0 2.298802582232397 0.8133285189380164 20.75456497860457 -6.675747380856657 1.9178470670657501 1.8249161286003457 0.8192612328811157 0.30447408145736077 0.5509871414989407 0.44799349721087456 3.1822379587956844 0.23089154963169892 0.6121086895673505 2.1098550473794596e-07 6.675747380856657 -1.00565489571923 GIVEFASK(ub)PAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIVEFASKPAAR 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 10969400.0 5343700.0 2700900.0 2924800.0 True False 5174067.168493499 3779383.4550074283 2158707.137880791 1.0 0.7304473119369743 0.4172166822699614 22.302867352187857 -6.969152277606689 0.27768582972508915 1.0709573782166704 0.0671918449971495 0.9999749950863477 0.001190817638712032 0.07657872862599197 0.01001067959268541 0.00586397630103682 0.028835592303691957 1.073612903139542e-07 6.969152277606689 -1.0037655332195208 down GIVEFASK(ub)PAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIVEFASKPAAR 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 16930400.0 5264700.0 3439100.0 8226600.0 True False 7986934.801125453 2825365.735189055 6600608.9041531235 1.0 0.3537484411154737 0.8264257901821135 22.92921050606122 -9.858466047281434 6.296364024873838 1.0000000266181763 0.5900871156488341 0.5006863381959009 0.192969719697779 7.229788667473326e-08 1.2823398894957776e-08 0.1868421415986012 0.06228070922593534 1.3852684806285102e-10 9.858466047281434 -0.40991291096934224 GIVEFASK(ub)PAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIVEFASKPAAR 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 6225400.0 1349400.0 3541300.0 1334700.0 True False 1848309.646163843 3384833.6564869243 1019471.3490093534 1.0 1.8313130938379987 0.551569565805849 20.81777504012746 -6.731363488784499 1.7181371540948749 1.4995133723210032 0.5521213392978724 0.5656375601179697 0.3494280994542767 0.3336839687815997 1.9303623249946045 0.1611229208039066 0.39921844705598125 1.8562501904324512e-07 6.731363488784499 -0.9473920330231308 GIVEFASK(ub)PAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIVEFASKPAAR 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 11358900.0 5343700.0 3838000.0 2177200.0 True False 4443523.316048714 3817323.9322166434 2632442.45376459 1.0 0.859075931576544 0.5924223339296933 22.083272627622133 -6.961114277028653 0.419437706438335 1.011858156949877 0.4295905886692795 0.9998093106303271 0.002333874942243951 0.07930550462601614 0.01967843970214072 0.0034481772443226326 0.022200338118942328 1.0936685485769005e-07 6.961114277028653 -0.5822675682805976 GIVEFASK(ub)PAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIVEFASKPAAR 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 20098800.0 5264700.0 10008500.0 4825600.0 True False 6815257.932751875 9451518.17682142 3947390.314837296 1.0 1.386817383888077 0.5791989611820036 22.70033682815367 -6.7764553915893995 1.5496156783224064 1.2200324152279038 0.5734904882926971 0.7546779831046022 0.1633529491841427 0.2561165546802734 1.2144891966266376 0.0830480350790656 0.19655241497621637 1.6731874884587506e-07 6.7764553915893995 -0.6465419269352067 GIVEFASKPAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIVEFASKPAAR 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 5425310.0 676810.0 2148200.0 2600300.0 False True 887304.4642373635 1827696.9336180165 2331245.899838887 1.0 2.059830652592195 2.6273348031023245 19.759069701484158 -9.187601541862241 0.192820008592337 2.0895357754913748e-22 3.246684517525433 0.9995836447722134 0.013761291826785428 0.6314380579053775 0.06900606535901477 0.7134840093243157 0.3307588274332646 6.492298181986164e-10 9.187601541862241 3.246684517525433 GIVEFASKPAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIVEFASKPAAR 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 10469010.0 676810.0 4889400.0 4902800.0 False True 927044.9471025277 4673370.140916373 3744859.616335544 1.0 5.041147309548428 4.03956639647309 19.82227976300705 -10.441315036537176 6.717969606697959 0.9993750886660503 4.540356853010759 0.9433731042481991 0.408893695524242 0.0038274043444768 0.00031829750182667916 0.3959422513761774 0.13196987276121633 3.61980323196444e-11 10.441315036537176 3.540981764344709 GIVEFSGK(ub)PAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIVEFSGKPAAR 12 1 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 36589200.0 4083100.0 22769000.0 9737100.0 True False 5352983.640796643 19371953.95286686 8729598.296858536 1.0 3.6189077443143245 1.6307911405384714 22.351911812976965 -6.5760662641539085 2.2813535280580437 2.7874988233437934 1.6352450790922168 0.0 1.1388312580771573 0.7112315564234181 6.956215620685046 0.42008741277124234 1.275061525203993 2.6542005562021975e-07 6.5760662641539085 -1.1522537442515766 GIVEFSGK(ub)PAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIVEFSGKPAAR 12 1 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 65712800.0 17602000.0 18855700.0 29255100.0 True False 17043234.144847654 26384879.34117648 21592311.675812505 1.0 1.5481145841766717 1.266913984300338 24.02269579332008 -10.096177874060077 4.618750476360401 0.9999727345796658 1.4075142842486392 0.736857236682537 0.11479966421154965 3.223356433979004e-05 6.307709910024697e-06 0.11116172462943152 0.03705143229857459 8.013497872063129e-11 10.096177874060077 0.4075415496689734 GIVEFSGK(ub)PAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIVEFSGKPAAR 12 1 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 128739000.0 6420400.0 24551600.0 97767000.0 True False 9740216.194112837 20170175.157473654 78443309.59720166 1.0 2.0708139075665355 8.053549123952116 23.21552236408692 -6.937362252786428 0.6836619704848728 0.9288016192257013 9.548961809433582 0.997797599148793 0.14565226298025885 0.08899088536181121 0.060245622954467025 0.13909343707718544 0.5211879598538632 1.1551483103881311e-07 6.937362252786428 8.62016019020788 GIVEFSGK(ub)PAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIVEFSGKPAAR 12 1 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 31458500.0 4083100.0 13385300.0 13990100.0 True False 5592732.411628563 12793893.186732115 10685926.515153775 1.0 2.2875925835698308 1.9106808137173348 22.415121874499857 -10.072692909960832 4.953560393741683 0.9999719735434826 2.099136698650589 0.9189540972320791 0.15387358572224405 4.7629384919816874e-05 8.916096161346922e-06 0.1489912416304021 0.0496624862401576 8.458767539977105e-11 10.072692909960832 1.0991647251071064 GIVEFSGK(ub)PAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIVEFSGKPAAR 12 1 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 63084800.0 17602000.0 28792700.0 16690100.0 True False 14636842.900815789 28637588.010196537 20179922.743696667 1.0 1.9565413254931097 1.3787073401308374 23.803101068754355 -10.30232295919526 6.0154326199338355 0.9999575752821778 1.6676243328119311 0.6402755112814313 0.23589973669607245 0.00013425381685638923 1.5570648279345243e-05 0.22842337508221724 0.07613631263321634 4.985136343944468e-11 10.30232295919526 0.6676667575297534 GIVEFSGK(ub)PAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIVEFSGKPAAR 12 1 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 112467500.0 6420400.0 27399100.0 78648000.0 True False 8311334.36500468 25874315.99925538 64334870.99662704 1.0 3.113136214107879 7.740618794920882 22.986648686179368 -6.958233010546981 0.4596596644796692 0.864657780936751 10.175533588034526 0.9996989466916552 0.048841672427775706 0.08033846472949849 0.02350995651426659 0.06281017761314658 0.382290882542122 1.10094846290434e-07 6.958233010546981 9.310875807097775 GIVEFSGKPAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIVEFSGKPAAR 12 1 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 12126000.0 2090700.0 5554900.0 4480400.0 False True 2740927.9463675977 4726130.572830608 4016811.1870315596 1.0 1.724281216182239 1.4654931707908705 21.386232972356716 -10.416361643262311 5.583391595417815 0.9996720911610573 1.594887193486557 0.8757088553812955 0.10564977712351854 0.0004314724496765337 4.5102244584375955e-05 0.10234950619815322 0.03409831894415823 3.83387859946338e-11 10.416361643262311 0.5952151023254997 GIVEFSGKPAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIVEFSGKPAAR 12 1 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 11475100.0 3997200.0 1140400.0 6337500.0 False True 3870311.073956659 1595767.667107436 4677518.629075327 1.0 0.41230992460667154 1.2085639990414132 21.884018096112136 -6.708984876709593 1.7989098228510585 0.6383211762368431 1.206629419713762 0.46020870232601063 0.24768977951112525 0.37713592453005695 2.378426391440409 0.10959973949341421 0.278769122877319 1.9544075122646922e-07 6.708984876709593 0.5683082434769188 GIVEFSGKPAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIVEFSGKPAAR 12 1 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 60733400.0 1685200.0 56226000.0 2822200.0 False True 2556571.604622605 46192031.00425689 2264390.9329857966 1.0 18.06795902791686 0.8857138712217141 21.285779003010777 -6.5230247865196445 2.505293907303544 9.999999999999998 0.8817916926108467 0.2517414694396296 6.983288814075475 0.5712723496809395 6.700324745913781 2.688855724492271 8.797922157848303 2.9989913524578886e-07 6.5230247865196445 -9.118208307389152 GIVEFSGKPAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIVEFSGKPAAR 12 1 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 13531000.0 2090700.0 5400500.0 6039800.0 False True 2863688.289043088 5161888.052934687 4613323.633585596 1.0 1.8025313972490877 1.6109726925367132 21.449443033879607 -10.047584149037252 4.543642401121522 0.9999682239285895 1.7067520448479558 0.947779820390371 0.07820351387040357 11697541.501503386 8635373.060821375 3439.7981984592598 0.026771143094101117 8.962225167648603e-11 10.047584149037252 0.7067838209193663 GIVK(ub)DIIHDPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIVKDIIHDPGR 12 1 P62917;E9PKZ0;E9PKU4;G3V1A1 P62917 RPL8 60S ribosomal protein L8 1 9772700.0 1756800.0 1146300.0 6869600.0 True False 1701031.3456237023 1604023.5678755296 5070245.676417498 1.0 0.942971199209381 2.980689150415647 20.69797829572183 -6.900460996857722 0.9583411685760436 0.9163474770030865 3.1966016624534577 0.9867944929755736 0.10887455349251293 0.11106700258084794 0.17550890809547234 0.08513109996961363 0.22201517672883997 1.2575897909881186e-07 6.900460996857722 2.2802541854503713 up GIVK(ub)DIIHDPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIVKDIIHDPGR 12 1 P62917;E9PKZ0;E9PKU4;G3V1A1 P62917 RPL8 60S ribosomal protein L8 1 6861200.0 1756800.0 1968700.0 3135700.0 True False 1460857.0394360423 1958094.222343646 3791360.372161319 1.0 1.3403736091106901 2.5952986978280626 20.478383571156105 -6.946748965018784 0.5934629778298096 0.9856368658906528 3.013558334466587 0.9989208356420044 0.022536348006556003 0.08481805404900702 0.041571784894973464 0.02328167259770902 0.10524223881927978 1.130449158712712e-07 6.946748965018784 2.027921468575934 up GIVLLEELLPKGSK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIVLLEELLPKGSK 14 1 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 20544900.0 8956300.0 5060100.0 6528500.0 True False 8671987.158930754 7080624.318072898 4818489.999198152 1.0 0.8164938656281325 0.5556385071714366 23.047931189742823 -6.966135082788629 0.33800618866006127 1.0289550215014758 0.3345345400471748 0.9999346656776795 0.001473704204483558 0.07757786780525101 0.013513364202929702 0.0037052220006079033 0.02261145624676344 1.0810976348042156e-07 6.966135082788629 -0.6944204814543009 GIVLLEELLPKGSK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIVLLEELLPKGSK 14 1 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 10046100.0 1968600.0 5356200.0 2721300.0 True False 2696444.6194146583 5119545.373415207 2078584.986932761 1.0 1.8986280439635184 0.7708613675826127 21.362626972868064 -6.69448135414662 1.8507680337423364 1.561020087536223 0.7745703521473931 0.39129606261104366 0.37972103897210335 0.4071389547427876 2.7072789220499494 0.16393395048950446 0.42445645852369246 2.020778189541721e-07 6.69448135414662 -0.7864497353888299 GIVLLEELLPKGSK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIVLLEELLPKGSK 14 1 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 11188900.0 8956300.0 0.0 2232600.0 True False 7447560.28136442 0.0 2699426.3376239324 1.0 0.0 0.36245780304438 22.8283364651771 -10.598607974977222 6.4255983754220605 1.0021576378912576 0.18122890152220394 0.8718566052147277 0.14797277845815573 0.00458115327753117 0.0002861734746544715 0.14350482422938463 0.04775800888837303 2.519950587671287e-11 10.598607974977222 -0.8209287363690536 GIVVTAYSPLGSPDRPWAKPEDPSLLEDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIVVTAYSPLGSPDRPWAKPEDPSLLEDPR 30 2 P15121;E9PCX2 P15121 AKR1B1 Aldose reductase 0 125907100.0 45894100.0 16685000.0 63328000.0 False True 69624705.00813572 13707431.389499977 50811193.0423516 1.0 0.19687597079080263 0.7297868340902021 26.05309597414426 -9.99784203907902 6.3397502338464395 1.0000002378346016 0.46333140246049337 0.5748666600442445 0.2175599489116485 7.312204075777744e-07 1.1585873878574385e-07 0.21065160890010223 0.07021717157803899 1.0049812540473921e-10 9.99784203907902 -0.5366688353741083 GIVVTAYSPLGSPDRPWAKPEDPSLLEDPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIVVTAYSPLGSPDRPWAKPEDPSLLEDPR 30 2 P15121;E9PCX2 P15121 AKR1B1 Aldose reductase 0 166260100.0 45894100.0 71423000.0 48943000.0 False True 59410817.15795928 67448247.26413713 40035876.1975882 1.0 1.1352856346817823 0.6738819311497146 25.82422229623671 -6.828202489382716 1.3358412087423737 1.0723847560434607 0.6619090320983718 0.9022401698335032 0.06055180622578149 0.18304524794969546 0.6394386978602142 0.0355957345606031 0.08192746281370772 1.4852429877163202e-07 6.828202489382716 -0.4104757239450889 GIWSIHVYCVDNILVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIWSIHVYCVDNILVK 16 0 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 0 15736500.0 3106100.0 5596100.0 7034300.0 False True 4712180.786326998 4597432.232471137 5643967.52175679 1.0 0.9756485247363984 1.1977400226522488 22.16796345962457 -6.879720581965962 1.0814021650228005 0.9849641061725651 1.2133925631775468 0.9734573663203905 0.01620285170350115 0.12787574542718536 0.27380923217452646 0.011545142427737808 0.027898338700314572 1.319105156485998e-07 6.879720581965962 0.2284284570049817 GIWSIHVYCVDNILVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIWSIHVYCVDNILVK 16 0 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 0 3106100.0 3106100.0 0.0 0.0 False True 4020907.680384557 0.0 0.0 1.0 0.0 0.0 21.93908978171702 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 GIYAYGFEK(ub)PSAIQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIYAYGFEKPSAIQQR 16 1 P38919;I3L3H2;J3QQP0;E9PBH4;F8WE11;P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9;J3KSN7;J3KT04;J3KS93;E7EMV8;Q14240-2;Q14240;E7EQG2 P38919;P60842;Q14240-2 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 124041000.0 0.0 74538000.0 49503000.0 True False 0.0 63417220.94684838 44380904.4263064 0.0 GIYAYGFEK(ub)PSAIQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIYAYGFEKPSAIQQR 16 1 P38919;I3L3H2;J3QQP0;E9PBH4;F8WE11;P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9;J3KSN7;J3KT04;J3KS93;E7EMV8;Q14240-2;Q14240;E7EQG2 P38919;P60842;Q14240-2 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 164254000.0 41594000.0 54063000.0 68597000.0 True False 40273621.23740446 75650637.83482055 50629387.83411123 1.0 1.8784165791517997 1.257135223467036 25.263331863497008 -10.014045940470602 5.996363862199594 0.999999304918586 1.5677759013094725 0.5268659943546803 0.25363705135557013 2.3566891633377815e-06 3.875299335521692e-07 0.24558331902411093 0.08186100632341145 9.681754354625228e-11 10.014045940470602 0.5677765963908865 GIYAYGFEK(ub)PSAIQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIYAYGFEKPSAIQQR 16 1 P38919;I3L3H2;J3QQP0;E9PBH4;F8WE11;P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9;J3KSN7;J3KT04;J3KS93;E7EMV8;Q14240-2;Q14240;E7EQG2 P38919;P60842;Q14240-2 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 454795000.0 90783000.0 72172000.0 291840000.0 True False 137724448.12630752 59292342.71759018 234157696.0819838 1.0 0.430514287944091 1.7001897576473646 27.037209441010546 -6.784784001617758 1.5172049860845658 0.6795364639471805 1.7117994834392851 0.7839295648551085 0.24136843745584197 0.24322954733440472 1.1061122859208792 0.12526326877618718 0.294412631396311 1.64140593110343e-07 6.784784001617758 1.0322630194921047 GIYAYGFEK(ub)PSAIQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIYAYGFEKPSAIQQR 16 1 P38919;I3L3H2;J3QQP0;E9PBH4;F8WE11;P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9;J3KSN7;J3KT04;J3KS93;E7EMV8;Q14240-2;Q14240;E7EQG2 P38919;P60842;Q14240-2 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 101446000.0 0.0 61639000.0 39807000.0 True False 0.0 58915585.16708483 30405406.45089933 0.0 GIYAYGFEK(ub)PSAIQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIYAYGFEKPSAIQQR 16 1 P38919;I3L3H2;J3QQP0;E9PBH4;F8WE11;P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9;J3KSN7;J3KT04;J3KS93;E7EMV8;Q14240-2;Q14240;E7EQG2 P38919;P60842;Q14240-2 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 160969000.0 41594000.0 79534000.0 39841000.0 True False 34587253.92662946 79105534.5557371 48171568.896029286 1.0 2.2871296670023304 1.3927549437204951 25.043737138931284 -10.140888356209699 4.666184412023419 0.9999190255526038 1.8399423053361446 0.5404361970825733 0.36512695184982963 0.000312697943177408 5.757135013856199e-05 0.35356701125968476 0.1178442169754008 7.229556294333932e-11 10.140888356209699 0.8400232797835407 GIYAYGFEKPSAIQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIYAYGFEKPSAIQQR 16 1 P38919;I3L3H2;J3QQP0;E9PBH4;F8WE11;P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9;J3KSN7;J3KT04;J3KS93;E7EMV8;Q14240-2;Q14240;E7EQG2 P38919;P60842;Q14240-2 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 261770000.0 77810000.0 73530000.0 110430000.0 False True 102009663.51311192 62559610.61769507 99003762.91935867 1.0 0.613271414326878 0.9705331780320314 26.60413058621797 -10.453862228352964 8.68400944371353 1.0000037635848271 0.7919022974156343 0.3114733980288149 0.14585150428073346 1.062782214867294e-05 6.68232512427406e-07 0.14122266463181138 0.047073370591548376 3.5167198406915635e-11 10.453862228352964 -0.20810146616919278 GIYAYGFEKPSAIQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GIYAYGFEKPSAIQQR 16 1 P38919;I3L3H2;J3QQP0;E9PBH4;F8WE11;P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9;J3KSN7;J3KT04;J3KS93;E7EMV8;Q14240-2;Q14240;E7EQG2 P38919;P60842;Q14240-2 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 165185000.0 51688000.0 18755000.0 94742000.0 False True 50047192.732580796 26243969.30603296 69926228.00092378 1.0 0.524384443424498 1.397205800824103 25.57678581130737 -6.758765588120328 1.617457787549863 0.7233080124257002 1.4001640072756678 0.6857804595866577 0.20000907303548704 0.28499396425763135 1.4692646368141518 0.09758611156228796 0.23476965722344542 1.7427472731681714e-07 6.758765588120328 0.6768559948499676 GIYAYGFEKPSAIQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GIYAYGFEKPSAIQQR 16 1 P38919;I3L3H2;J3QQP0;E9PBH4;F8WE11;P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9;J3KSN7;J3KT04;J3KS93;E7EMV8;Q14240-2;Q14240;E7EQG2 P38919;P60842;Q14240-2 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 278826000.0 31611000.0 217600000.0 29615000.0 False True 47956198.073655955 178767579.88344008 23761582.269284394 1.0 3.727726280737911 0.4954851139948368 25.515213951869 -6.6830111370652885 1.8910848638552376 2.7212477930225685 0.5074986853201996 0.337837214564778 1.155336795862842 0.43196949977114146 2.98924354527363 0.48974545600257047 1.2867585462996616 2.0748603089708506e-07 6.6830111370652885 -2.2137491077023688 GIYAYGFEKPSAIQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIYAYGFEKPSAIQQR 16 1 P38919;I3L3H2;J3QQP0;E9PBH4;F8WE11;P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9;J3KSN7;J3KT04;J3KS93;E7EMV8;Q14240-2;Q14240;E7EQG2 P38919;P60842;Q14240-2 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 265665000.0 77810000.0 98776000.0 89079000.0 False True 106578459.73618549 94411749.7114483 68040374.8395925 1.0 0.8858426922770929 0.6384064379238862 26.66734064774086 -6.95844234782701 0.4568648473820107 1.0074426055210601 0.5068842980773971 0.9997079684055054 0.002579148733531219 0.08026242765733087 0.02322400171861991 0.003342930809227783 0.02044809027163884 1.1004179150155452e-07 6.95844234782701 -0.500558307443663 GIYAYGFEKPSAIQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GIYAYGFEKPSAIQQR 16 1 P38919;I3L3H2;J3QQP0;E9PBH4;F8WE11;P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9;J3KSN7;J3KT04;J3KS93;E7EMV8;Q14240-2;Q14240;E7EQG2 P38919;P60842;Q14240-2 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 113562000.0 51688000.0 30839000.0 31035000.0 False True 42980862.16664969 30672864.185937785 37524275.01037292 1.0 0.7136400397695581 0.8730461214314421 25.357191086741647 -10.12460927639788 4.980601204356487 1.000009021475715 0.7933430809619652 0.691446871746173 0.06507726033021692 6.519432936409688e-06 1.145819275608334e-06 0.06301353638140861 0.02100359545599525 7.505691734900383e-11 10.12460927639788 -0.20666594051374976 GIYAYGFEKPSAIQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GIYAYGFEKPSAIQQR 16 1 P38919;I3L3H2;J3QQP0;E9PBH4;F8WE11;P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9;J3KSN7;J3KT04;J3KS93;E7EMV8;Q14240-2;Q14240;E7EQG2 P38919;P60842;Q14240-2 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 133993000.0 31611000.0 61285000.0 41097000.0 False True 40921062.64596642 57874435.87615536 33617767.69082976 1.0 1.4142945498962998 0.8215272409144893 25.28634027396145 -6.71881536172721 1.7637137509930896 1.2523711808498168 0.8225203819978122 0.50687147810845 0.1743623444149032 0.35761811319016296 2.173450845398459 0.07851900654148372 0.1973771279203153 1.910665396394811e-07 6.71881536172721 -0.4298507988520046 GIYFADMVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GIYFADMVSK 10 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 3697900.0 3697900.0 0.0 0.0 False True 4847982.710514535 0.0 0.0 1.0 0.0 0.0 22.208953123023772 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 GIYFADMVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GIYFADMVSK 10 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 16716000.0 3697900.0 8061300.0 4956800.0 False True 5065113.561989971 7705125.110845745 3786105.9285004605 1.0 1.521214680884385 0.7474868790529117 22.272163184546663 -6.725233252119064 1.7404025203032334 1.3153247741807725 0.7483198624856067 0.5370368109699968 0.2192020211492376 0.3452929247847298 2.0466503689732147 0.09989755099912913 0.24925766683081016 1.8826376854923348e-07 6.725233252119064 -0.5670049116951659 GK(ub)ADGGAEYATYQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKADGGAEYATYQTK 15 1 P15529-2;P15529-16;P15529-5;P15529-3;P15529-6;P15529-4;P15529-7;R4GN18 P15529-2 CD46 Membrane cofactor protein 1 14184400.0 7265000.0 4773600.0 2145800.0 True False 9524485.354360087 4061397.4873470576 1923773.1999670377 1.0 0.42641647671680705 0.2019818529183185 23.183209709513164 -11.007060847821322 0.18496790697803187 2.002312211583806 1.240496862146638e-13 0.9994556542443921 0.007839819322139273 3.1331727129905613 0.10436595812592651 1.4896304349205582 0.1543273758583964 9.838732482930437e-12 11.007060847821322 -2.002312211583682 GK(ub)ADGGAEYATYQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKADGGAEYATYQTK 15 1 P15529-2;P15529-16;P15529-5;P15529-3;P15529-6;P15529-4;P15529-7;R4GN18 P15529-2 CD46 Membrane cofactor protein 1 11570600.0 3908800.0 3773600.0 3888200.0 True False 3784717.2835689476 5280418.159064028 2869763.7765003038 1.0 1.3951948754504198 0.7582505010239886 21.851754104983886 -6.738892398707831 1.690767797135322 1.2354393226111222 0.7579672439347372 0.5999655763141122 0.16604863139699663 0.3198174658109378 1.7947307398739305 0.07770709307484722 0.19091737352598173 1.8243476487673513e-07 6.738892398707831 -0.47747207867638497 GK(ub)ADGGAEYATYQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKADGGAEYATYQTK 15 1 P15529-2;P15529-16;P15529-5;P15529-3;P15529-6;P15529-4;P15529-7;R4GN18 P15529-2 CD46 Membrane cofactor protein 1 13516000.0 7265000.0 2951400.0 3299600.0 True False 9951066.829242872 2820997.389025359 2520302.437395118 1.0 0.2834869303395076 0.25326957206123757 23.246419771036056 -13.36006568039201 0.45815613447847564 9.999999999999968 0.25358035907519105 0.9998975722193124 0.003492740143220768 20.222611284037523 0.23121697127522658 180.80310450442093 0.006700944669943438 4.364498208946516e-14 13.36006568039201 -9.746419640924778 GK(ub)ADGGAEYATYQTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKADGGAEYATYQTK 15 1 P15529-2;P15529-16;P15529-5;P15529-3;P15529-6;P15529-4;P15529-7;R4GN18 P15529-2 CD46 Membrane cofactor protein 1 12513900.0 3908800.0 6130900.0 2474200.0 True False 3250340.3892005933 6097871.624811632 2991543.7805917417 1.0 1.8760717016199573 0.9203786134311608 21.632159380418162 -6.66556838165399 1.9527409950570729 1.5612868609940669 0.9242743711074985 0.2597676998036277 0.37251590311890775 0.471337679020058 3.4605126858821698 0.15380080850317224 0.41335788143934893 2.1598899234449006e-07 6.66556838165399 -0.6370124898865683 GK(ub)ATISNDGATILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKATISNDGATILK 14 1 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 1 25288100.0 8952700.0 11805900.0 4529500.0 True False 11737076.398070129 10044505.739037776 4060830.790032018 1.0 0.8557928225370797 0.3459831607383693 23.484569754833377 -6.947714226708601 0.5834000464015365 1.0060195251467052 0.17039280829781725 0.9990094698870975 0.008830065334751672 0.08441681765159768 0.03986280282608155 0.009217920288737358 0.04262748157220961 1.1279394157099221e-07 6.947714226708601 -0.835626716848888 down GK(ub)ATISNDGATILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKATISNDGATILK 14 1 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 1 49550800.0 15301100.0 18374100.0 15875600.0 True False 14815374.955898695 25710973.949665677 11717304.10220879 1.0 1.7354251260059357 0.7908881237962582 23.82059180351581 -6.6989169624162725 1.8344042628135957 1.4571652318960713 0.7937317165174813 0.41243402208216007 0.31049694139947365 0.3978633618870417 2.6020316248366164 0.13506250245546206 0.3478525035512763 2.0002442819846303e-07 6.6989169624162725 -0.66343351537859 GK(ub)ATISNDGATILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKATISNDGATILK 14 1 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 1 24301900.0 8952700.0 9617300.0 5731900.0 True False 12262755.127620455 9192375.885841837 4378143.272186044 1.0 0.749617503585068 0.35702770108527865 23.547779816356268 -6.964510356350919 0.36635862337464975 1.0314646825366054 0.06159286566809171 0.9999026931069366 0.0026103548419769283 0.07812751289866215 0.015448205922446782 0.005205082228779678 0.03340899880945717 1.0851496724336173e-07 6.964510356350919 -0.9698718168685136 down GK(ub)ATISNDGATILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKATISNDGATILK 14 1 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 1 46057900.0 15301100.0 25465600.0 5291200.0 True False 12723542.60366281 25328411.758274145 6397565.456255368 1.0 1.9906729239844483 0.5028132223500127 23.600997078950087 -6.7272129924281545 1.733338260149054 1.5980182520459758 0.5041289006109523 0.5463413665354873 0.4165538011326044 0.34147816328646546 2.008619769517539 0.19054335535250938 0.474329340603998 1.8740751739840155e-07 6.7272129924281545 -1.0938893514350236 GK(ub)ATISNDGATILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKATISNDGATILK 14 1 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 1 43536600.0 17221400.0 8542200.0 17773000.0 True False 22293441.784544803 8066819.060802705 14538496.366379984 1.0 0.36184718083302525 0.6521422984789621 24.410116029224564 -10.465728958057909 6.1880373513584415 1.0002436477414385 0.5069947396560713 0.7936265555818669 0.1185124855089598 0.0003985571282282293 3.4410906994204884e-05 0.11480453923425495 0.03824974022448742 3.4219293751804004e-11 10.465728958057909 -0.49324890808536714 GK(ub)AVVLMGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKAVVLMGK 9 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 1 9796300.0 3275900.0 3877100.0 2643300.0 True False 4294736.623860723 3298651.79281743 2369796.6723240116 1.0 0.7680684711818556 0.5517909198803673 22.034138229651656 -6.971966504809963 0.2058653920083215 1.1193812701217554 0.1944682306626999 0.9999939297361304 0.00045088053059944174 0.07566959835168904 0.006695840792334544 0.006694295597878038 0.022631024561602847 1.0666783861886784e-07 6.971966504809963 -0.9249130394590555 GK(ub)AVVLMGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKAVVLMGK 9 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 1 14438700.0 4735900.0 4192800.0 5510000.0 True False 4585561.4468006 5867006.905163148 4066765.703543209 1.0 1.2794522488094948 0.8868632010984476 22.128666954600504 -6.715609453954146 1.7757416476356844 1.170813194848027 0.88764600316452 0.4914709014389427 0.1176622398346129 0.36390058445287327 2.2401861785822534 0.05266947611523104 0.13287639247762847 1.9248218767762218e-07 6.715609453954146 -0.2831671916835069 GK(ub)AVVLMGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKAVVLMGK 9 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 1 10045900.0 3275900.0 3120500.0 3649500.0 True False 4487088.757868778 2982625.9918864374 2787563.2638118216 1.0 0.6647129470429928 0.6212409457966291 22.097348291174548 -13.999999999999998 0.2879868266823411 3.8566416355001807 0.6091525469372072 0.9996229580823189 0.0032861350619218218 15.847233323330245 0.17013900739610607 26.788486359381086 0.01656903804920984 1.0000000000000041e-14 13.999999999999998 -3.2474890885629737 GK(ub)AVVLMGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKAVVLMGK 9 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 1 14534000.0 4735900.0 7811200.0 1986900.0 True False 3938110.6859432803 7769119.515198194 2402351.6036123773 1.0 1.9728037464587636 0.6100264302340074 21.90907223003478 -6.715024531692274 1.7770438157581734 1.5949510209277824 0.6126927096769358 0.4890530469940667 0.4096270597210079 0.365058576193624 2.2501058253982844 0.18322002697591888 0.4626946453165136 1.92741603749823e-07 6.715024531692274 -0.9822583112508466 GK(ub)AVVLMGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKAVVLMGK 9 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 1 7924600.0 3046900.0 2310900.0 2566800.0 True False 3944272.1133781006 2182296.383555637 2099668.737592083 1.0 0.5532824107529928 0.5323336416041048 21.911327655289238 GK(ub)DAFPVAGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKDAFPVAGQK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 15185100.0 7358700.0 6281600.0 1544800.0 True False 9647326.96175217 5344409.7654850185 1384958.914767955 1.0 0.5539782974779942 0.14355882414463284 23.20169783157753 -7.829770241901496 0.3961056756250063 1.0534812807617182 5.703132390867308e-18 0.9979836650677556 0.015704650179966514 0.11134999645397442 0.07308111241176696 0.035858896524633005 0.07973589086495504 1.4798910991030017e-08 7.829770241901496 -1.0534812807617182 down GK(ub)DAFPVAGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKDAFPVAGQK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 22716800.0 9962600.0 8924900.0 3829300.0 True False 9646342.716251539 12488659.112738647 2826291.4534624307 1.0 1.2946522303938626 0.29299098493575976 23.201550636551627 -6.827923632405875 1.337092687380657 1.1576812005254986 0.2671475522072572 0.9016816258283306 0.13179398759326827 0.18337848217832514 0.6419000685231069 0.07740674103081295 0.17816292631861036 1.4861969564699627e-07 6.827923632405875 -0.8905336483182413 down GK(ub)DAFPVAGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKDAFPVAGQK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 39032300.0 20508000.0 12197000.0 6327300.0 True False 31112135.33562803 10020350.05440404 5076706.381645896 1.0 0.3220720772234893 0.1631744760325824 24.89097407973318 -13.999999999999998 0.20381341896682334 4.824437791861503 0.06377175901005747 0.9994874895643706 0.008215039056613426 12.608890178518747 0.1431313339797579 19.255075020922146 0.09837462506949651 1.0000000000000041e-14 13.999999999999998 -4.760666032851446 GK(ub)DAFPVAGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKDAFPVAGQK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 16216900.0 7358700.0 6934400.0 1923800.0 True False 10079410.251390155 6628015.279005702 1469438.061904693 1.0 0.6575796712006602 0.14578611498644256 23.26490789310042 -7.419575669970995 0.4875590404330152 1.0148832087759767 3.4331226595218434e-27 0.997954901249039 0.015873596288947765 0.11163371737100714 0.05831965001795726 0.018326610468286684 0.0638203941537594 3.8056104418192554e-08 7.419575669970995 -1.0148832087759767 down GK(ub)DAFPVAGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKDAFPVAGQK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 25471200.0 9962600.0 12467000.0 3041600.0 True False 8284343.318013162 12399837.796494257 3677584.4972305605 1.0 1.4967798074631358 0.4439198565363847 22.981955911985903 -6.778406018155351 1.5422265770978876 1.2818676474676047 0.4360085635178876 0.7616849570340211 0.2099424234093758 0.253044275525784 1.1886956903934047 0.10723443704248131 0.2533521470798154 1.6656892459286433e-07 6.778406018155351 -0.8458590839497171 down GK(ub)DAFPVAGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKDAFPVAGQK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 38574600.0 20508000.0 12596000.0 5470600.0 True False 26548010.27311633 11895021.527226131 4475006.933096171 1.0 0.4480569882584213 0.16856279951148573 24.66210040182563 -9.006762089513579 0.2612026963796202 1.300722569456647 2.0637510048344483e-23 0.9990508524835439 0.010642825995461758 0.47067074463452135 0.08872983348448507 0.23925761109345428 0.10875740767839379 9.845503037135382e-10 9.006762089513579 -1.300722569456647 GK(ub)DCAVIVTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKDCAVIVTQK 11 1 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 13225200.0 3496500.0 6335800.0 3392900.0 True False 4583945.360154168 5390523.336754971 3041835.2549949475 1.0 1.1759571533317048 0.6635845360278562 22.128158416842982 -6.8140265955190555 1.397801361325209 1.0954479677603275 0.653793826060814 0.870016764762183 0.07663712471394468 0.20136432854287778 0.7746652983468904 0.04310380578595825 0.0995263711504872 1.5345230081179568e-07 6.8140265955190555 -0.44165414169951345 GK(ub)DCAVIVTQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKDCAVIVTQK 11 1 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 14723600.0 3930100.0 6513600.0 4279900.0 True False 3805341.1267279764 9114514.447975276 3158865.795752186 1.0 2.395189851431899 0.830113698234549 21.8595943580804 -6.671639863960023 1.931876356495434 1.8893203989905842 0.8364471881936609 0.2861366097410961 0.592429971495325 0.4574010646981396 3.2927498129282418 0.24675921384109875 0.6577962850018174 2.129904524161027e-07 6.671639863960023 -1.0528732107969234 GK(ub)DCAVIVTQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKDCAVIVTQK 11 1 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 21525700.0 6228500.0 11066800.0 4230400.0 True False 9449089.864343625 9091843.07469695 3394259.5857498106 1.0 0.962192465647432 0.35921550482424064 23.171743945067163 -6.919694972864274 0.8269929779236475 1.0134513746882399 0.26266130725651093 0.9940955664631402 0.022557504902806568 0.09835175362866103 0.10654928045298398 0.019404209951532938 0.0579558101263601 1.20310914277406e-07 6.919694972864274 -0.7507900674317289 down GK(ub)DCAVIVTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKDCAVIVTQK 11 1 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 8479000.0 3496500.0 2560900.0 2421600.0 True False 4789250.539359626 2447750.9702361748 1849667.954417508 1.0 0.5110926960533296 0.38621240196484447 22.191368478365874 -13.999999999999996 0.19163648942276498 3.6358245497141226 0.298082383092778 0.9994885910298513 0.0059896503573022555 12.377844218380035 0.13882493551477842 12.189662389392478 0.08477747807777893 1.0000000000000082e-14 13.999999999999996 -3.3377421666213447 GK(ub)DCAVIVTQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKDCAVIVTQK 11 1 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 15394300.0 3930100.0 6584000.0 4880200.0 True False 3268052.282950585 6548530.685178316 5900627.256504656 1.0 2.003802301248965 1.8055486098824685 21.639999633514677 -10.170969030669351 4.736784989280117 0.9998929587045068 1.904675455571318 0.9652343013060357 0.08093673059775595 9.150249485220592e-05 1.6014705776661146e-05 0.0783758154430141 0.026122217472405024 6.745761296822358e-11 10.170969030669351 0.9047824968668111 GK(ub)DCAVIVTQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKDCAVIVTQK 11 1 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 19496200.0 6228500.0 13267700.0 0.0 True False 8062916.032090157 12529340.831754355 0.0 1.0 1.5539465848196812 0.0 22.942870267159613 -6.828392809704543 1.4568639687932405 1.3005534645822374 1.7374614533241615e-20 0.8600232958147199 0.24058684154057067 0.1964625082129126 0.8360804744477076 0.13207572552558253 0.28681374182845004 1.4845922541547452e-07 6.828392809704543 -1.3005534645822374 down GK(ub)DESQHTESMVLQSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKDESQHTESMVLQSSR 17 1 Q53GS7;Q53GS7-2 Q53GS7 GLE1 Nucleoporin GLE1 1 41692800.0 1410000.0 5458800.0 34824000.0 True False 2139073.0848076623 4484634.490200928 27941021.136098575 1.0 2.0965316809659966 13.062209671349743 21.02855434462204 -6.926196357975668 0.7773888862326843 0.8076427269809604 15.10976665061828 0.9957361997407161 0.35562179820589135 0.09466170162057237 0.08771525826376952 0.3169355092855232 1.013748709372806 1.1852327465999211e-07 6.926196357975668 14.30212392363732 GK(ub)DESQHTESMVLQSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKDESQHTESMVLQSSR 17 1 Q53GS7;Q53GS7-2 Q53GS7 GLE1 Nucleoporin GLE1 1 3840780.0 593340.0 743140.0 2504300.0 True False 812713.8324105927 710305.6175646497 1912835.917677473 1.0 0.8739922826929256 2.3536401638493163 19.632387923614026 -6.886192952323667 1.0446153213309985 0.9130908179484006 2.471813498960384 0.9783485605145816 0.09855588623473581 0.12228748408216863 0.24031375729606164 0.07222078237472997 0.17775278553443838 1.2995920551073186e-07 6.886192952323667 1.5587226810119836 up GK(ub)DESQHTESMVLQSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKDESQHTESMVLQSSR 17 1 Q53GS7;Q53GS7-2 Q53GS7 GLE1 Nucleoporin GLE1 1 32461800.0 1410000.0 5339800.0 25712000.0 True False 1825272.7952552193 5042635.435938558 21032679.827398945 1.0 2.762674954147591 11.523033643011177 20.79968066671449 -6.939940178989124 0.6601220927713054 0.9015663403316567 13.881253785130959 0.9981560205779118 0.1976065350179684 0.08779402060923633 0.05473452745399955 0.19226755031980458 0.7541860090364864 1.1483117824768338e-07 6.939940178989124 12.979687444799302 GK(ub)DMVVDIQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKDMVVDIQR 10 1 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 1 3307820.0 1247600.0 979920.0 1080300.0 True False 1207995.6209017134 1371207.1662152905 797337.0216946866 1.0 1.1351093849096465 0.6600495961231309 20.20418379409078 -6.830702019026221 1.3246884912266808 1.0721604148806567 0.6470744748825499 0.9072850869995879 0.06085616412889759 0.17994747327003502 0.6173069241294693 0.036066803555605924 0.08300203274269803 1.4767194021441302e-07 6.830702019026221 -0.42508593999810684 GK(ub)DSLYAQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKDSLYAQGK 10 1 H0Y5B4;H7BZ11;J3KQN4;P83881;H7BY91;H0Y3V9 H0Y5B4 RPL36A;RPL36A-HNRNPH2 60S ribosomal protein L36a 1 4374020.0 831120.0 1240700.0 2302200.0 True False 804736.5505320865 1736117.9801650278 1699184.75548043 1.0 2.1573743345162066 2.111479532471764 19.61815703474765 -10.257964165124704 6.223703005362023 0.999972675288511 2.134426933493985 0.9987739661462469 0.018736474475825236 7.1042001934451114e-06 8.469893569210289e-07 0.018141947445164508 0.006047171134292009 5.521229946429336e-11 10.257964165124704 1.1344542582054742 GK(ub)DSLYAQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKDSLYAQGK 10 1 H0Y5B4;H7BZ11;J3KQN4;P83881;H7BY91;H0Y3V9 H0Y5B4 RPL36A;RPL36A-HNRNPH2 60S ribosomal protein L36a 1 2902300.0 616190.0 673410.0 1612700.0 True False 844012.094908625 643656.5195309238 1231813.474599073 1.0 0.7626152793469243 1.459473723220083 19.68690414770537 -6.814785303050969 1.3943857193999416 0.8713400233267315 1.4730387541929488 0.8719436171147262 0.10351414866208272 0.20034550014932123 0.7667844169731828 0.05835818832260549 0.13472210985414865 1.5318445541306958e-07 6.814785303050969 0.6016987308662173 GK(ub)DSLYAQGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKDSLYAQGK 10 1 H0Y5B4;H7BZ11;J3KQN4;P83881;H7BY91;H0Y3V9 H0Y5B4 RPL36A;RPL36A-HNRNPH2 60S ribosomal protein L36a 1 4322120.0 831120.0 1827100.0 1663900.0 True False 691113.104858881 1817257.0496490435 2011813.7969956372 1.0 2.629464029654178 2.9109761960112612 19.398562310181926 -10.258233435907949 0.38734215440597797 6.163275980899429e-13 2.944664719943094 0.9990840591961844 0.025493812549858733 1.6480750841707577 0.1790563063850608 1.815797070479771 0.07419905418295064 5.5178077405841316e-11 10.258233435907949 2.9446647199424776 GK(ub)EAIETQLAEYHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKEAIETQLAEYHK 14 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 9237500.0 1968700.0 2077500.0 5191300.0 True False 1906204.696111897 2907056.584019378 3831542.7943382664 1.0 1.525049534265091 2.010037433101229 20.862271619426664 -6.9720771891657085 0.2025174141456768 0.7205363035465309 2.8279778696090996 0.9999943730576916 0.0009783727672235756 0.07563428238442897 0.006559394132076182 0.015424547282932693 0.05116420973573938 1.0664065670171754e-07 6.9720771891657085 2.107441566062569 GK(ub)EAIETQLAEYHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKEAIETQLAEYHK 14 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 4969900.0 1968700.0 3001200.0 0.0 True False 1637061.278197709 2985031.939908444 0.0 1.0 1.8234087994523682 0.0 20.64267689486094 -6.793209449799547 1.544747502008906 1.463322459829399 2.280684324329452e-19 0.7807094262200679 0.349137292492783 0.23845254440281816 1.133622817122414 0.17957365325677652 0.40873633317613955 1.6098690467462265e-07 6.793209449799547 -1.463322459829399 GK(ub)ECCINR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKECCINR 8 1 Q9H0C5;Q9H0C5-2 Q9H0C5 BTBD1 BTB/POZ domain-containing protein 1 1 2935000.0 869790.0 1152300.0 912910.0 True False 1140303.113058341 980381.331630221 818450.8304510709 1.0 0.8597550251360772 0.7177484837833612 20.120985938959706 -6.970970005867353 0.23386285344570235 1.0550336742854953 0.5183933147974312 0.999988988318277 0.0003823321265693009 0.07598923662563853 0.007895090873498246 0.003547160178435387 0.01400043155934751 1.069128715024166e-07 6.970970005867353 -0.5366403594880641 GK(ub)ECCINR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKECCINR 8 1 Q9H0C5;Q9H0C5-2 Q9H0C5 BTBD1 BTB/POZ domain-containing protein 1 1 2423000.0 869790.0 631910.0 921300.0 True False 1191374.8681909353 603990.1267530713 703707.9147690989 1.0 0.506969001008231 0.590668758891697 20.184196000482597 -10.787593790364593 7.143745552434719 1.0137080286248532 0.548818879949964 0.9748382747646002 0.03417028306816426 0.007314999883203889 0.00021749784671690447 0.032441215209919196 0.011028411438182787 1.630820678679825e-11 10.787593790364593 -0.4648891486748892 GK(ub)EDALVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKEDALVTK 9 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 11412200.0 3406900.0 5058800.0 2946500.0 True False 4466478.892466528 4304046.759047951 2641624.444823784 1.0 0.9636330681663924 0.5914333210617719 22.090706513441702 -6.9258206989354605 0.7803376603894507 1.0066220173087523 0.5225661977966242 0.9956510588811225 0.012175459288510928 0.09486685849211546 0.08874335324116613 0.010828055350627998 0.03448392586489595 1.1862584009311613e-07 6.9258206989354605 -0.48405581951212817 GK(ub)EDALVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKEDALVTK 9 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 13987400.0 3983600.0 3211700.0 6792100.0 True False 6043412.4401700655 2638547.0418733633 5449638.457916821 1.0 0.4365988699257324 0.9017485587602002 22.52693197323226 -10.089820512476914 7.400649836882412 1.0000000607687538 0.6691737143429713 0.40279092822603857 0.18989656527646936 1.9048784005914162e-07 2.3508606742190715e-08 0.18386659295205848 0.061288852901479604 8.131665164910015e-11 10.089820512476914 -0.33082634642578246 GK(ub)EDALVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKEDALVTK 9 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 9965500.0 3406900.0 3218700.0 3339900.0 True False 4666522.998010666 3076487.1911824592 2551084.4073996707 1.0 0.6592675515569006 0.5466777745416009 22.153916574964594 -13.999999999999998 0.15476558796459358 2.6608469895485927 0.42934561699965107 0.9995511200272129 0.004083157091964436 11.978884856109449 0.12412341474608202 5.976220012043747 0.10627964354216175 1.0000000000000041e-14 13.999999999999998 -2.2315013725489417 GK(ub)EDALVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKEDALVTK 9 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 10281600.0 3983600.0 3246000.0 3052000.0 True False 5156848.72849552 3065357.246536674 2496567.3161644978 1.0 0.5944245037862442 0.4841265368846405 22.298058295324708 -13.999999999999998 0.182730846666916 3.1223424913517213 0.39893769330527934 0.9994950978780969 0.004983991612037535 12.241288697152331 0.13553245199033923 9.23032769715051 0.0804802644925894 1.0000000000000041e-14 13.999999999999998 -2.7234047980464418 GK(ub)EETEGFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKEETEGFK 9 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3 A0A3B3IRP5 CDC73 Parafibromin 1 3723500.0 0.0 3723500.0 0.0 True False 0.0 5210312.967795979 0.0 0.0 GK(ub)EETEGFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKEETEGFK 9 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3 A0A3B3IRP5 CDC73 Parafibromin 1 5335300.0 0.0 3350200.0 1985100.0 True False 0.0 3332151.807637364 2400175.2319346326 0.0 GK(ub)EGSALSHVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKEGSALSHVR 11 1 Q3MHD2-2;Q3MHD2;K7ELG9 Q3MHD2-2 LSM12 Protein LSM12 homolog 1 3745870.0 891870.0 1460500.0 1393500.0 True False 1169250.2068813653 1242599.0929844098 1249313.9873958742 1.0 1.0627315570879232 1.0684744634153676 20.157152253344396 -13.999992701407658 0.33831902989606544 0.2818426033160936 1.0693951216045494 0.9997318024749392 0.0005078802415482643 19.55091540962474 0.18647748187850507 10.033048126962093 0.0017850964397479183 1.0000168057711421e-14 13.999992701407658 0.7875525182884557 GK(ub)EGSALSHVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKEGSALSHVR 11 1 Q3MHD2-2;Q3MHD2;K7ELG9 Q3MHD2-2 LSM12 Protein LSM12 homolog 1 2863800.0 1274300.0 0.0 1589500.0 True False 1233848.0440165529 0.0 1173162.266022128 1.0 0.0 0.9508158413114843 20.234733297974614 -11.834807186827524 13.411176756727283 0.8529087494960661 0.5278671285899899 0.0 0.4762488030789914 0.0 0.0 0.0 0.1351064244753628 1.4628264795345715e-12 11.834807186827524 -0.32504162090607625 GK(ub)EGSALSHVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKEGSALSHVR 11 1 Q3MHD2-2;Q3MHD2;K7ELG9 Q3MHD2-2 LSM12 Protein LSM12 homolog 1 8993700.0 1387800.0 1433800.0 6172100.0 True False 2105394.0617702645 1177927.1876694683 4952181.729672474 1.0 0.5594806260064397 2.3521400670754073 21.00565885380587 -6.841714158721376 1.2744178308220941 0.7656845813338499 2.4131287008696476 0.927361910953062 0.205569859990966 0.1668048001039787 0.525512523425601 0.1264473586525303 0.29145656343774007 1.439745869587108e-07 6.841714158721376 1.6474441195357978 up GK(ub)EGSALSHVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKEGSALSHVR 11 1 Q3MHD2-2;Q3MHD2;K7ELG9 Q3MHD2-2 LSM12 Protein LSM12 homolog 1 4000470.0 891870.0 1232500.0 1876100.0 True False 1221618.4408804993 1178044.0746675332 1433003.8194923576 1.0 0.9643306250505196 1.1730371542684794 20.220362314867288 -6.862888490551502 1.1711424426482988 0.9804800427354147 1.1837114722470126 0.9570507051428179 0.0188898242569523 0.14385082691150394 0.37329807240098783 0.01256516630575515 0.02943114708222255 1.3712337989507216e-07 6.862888490551502 0.2032314295115979 GK(ub)EGSALSHVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKEGSALSHVR 11 1 Q3MHD2-2;Q3MHD2;K7ELG9 Q3MHD2-2 LSM12 Protein LSM12 homolog 1 5507280.0 1274300.0 2899080.0 1333900.0 True False 1059636.9110617859 2883462.080617673 1612812.3227432393 1.0 2.7211793497532692 1.522042414629702 20.01513857340889 -10.502790035001086 5.297540635056694 0.9973947331077967 2.1216108821914927 0.538426525966115 0.4895456037962979 0.015082971531730374 0.001415636523578225 0.47461808724905086 0.15800016422600602 3.142027378442654e-11 10.502790035001086 1.1242161490836962 GK(ub)EGSALSHVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKEGSALSHVR 11 1 Q3MHD2-2;Q3MHD2;K7ELG9 Q3MHD2-2 LSM12 Protein LSM12 homolog 1 11375800.0 1387800.0 2054000.0 7934000.0 True False 1796534.4576277966 1939693.094388891 6490093.4097146625 1.0 1.0796859955305984 3.6125627216103586 20.77678517589832 -6.91360602590312 0.8708291640101611 0.9302337219932723 3.9664428878776574 0.9922123544171665 0.10706449983171135 0.10208164104073796 0.1261943804354602 0.0892486755657587 0.2529756582317755 1.2200959178948788e-07 6.91360602590312 3.0362091658843853 up GK(ub)ELNEFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKELNEFR 8 1 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 1 4134900.0 1210200.0 1782200.0 1142500.0 True False 1586583.9195934725 1516302.7069611906 1024285.0596338627 1.0 0.9557028079231448 0.6455914792684356 20.597492401439716 -6.932665542603709 0.7245779307944098 1.0042810821179144 0.5773786182362695 0.9970366703127407 0.008582962696416027 0.09127728480792284 0.07107161818538736 0.007947347267512582 0.0276599737229989 1.1677085426278646e-07 6.932665542603709 -0.426902463881645 GK(ub)ELNEFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKELNEFR 8 1 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 1 8230000.0 2927300.0 2534600.0 2768100.0 True False 2834374.463823005 3546678.997764384 2043051.5687800266 1.0 1.2513092546637687 0.7208121562118359 21.434598942051565 -6.777874629759156 1.5440074662047711 1.142691214607962 0.716876488982875 0.7598333302695929 0.10618509533563107 0.2538977960007864 1.1953741327622778 0.054173149101957155 0.1280625266844936 1.6677285756955434e-07 6.777874629759156 -0.42581472562508693 GK(ub)ENQLQLSCFINQEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKENQLQLSCFINQEVK 17 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 9481100.0 4224900.0 1839100.0 3417100.0 True False 4090782.862093342 2573462.220779805 2522058.999197364 1.0 0.6290879539528795 0.6165223342865898 21.963945530628607 GK(ub)ENQLQLSCFINQEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKENQLQLSCFINQEVK 17 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 27066800.0 4046300.0 4114500.0 18906000.0 True False 5542326.45714596 3932707.7851679972 14440792.181292312 1.0 0.7095770730173044 2.6055470194602446 22.402060261059123 -6.867819202615398 1.1454865476238798 0.8377072345090125 2.7121164207907738 0.9624621834641122 0.16154383281195578 0.13896750519722934 0.34215157487484993 0.10958102081311134 0.2585154193083799 1.3557536969981127e-07 6.867819202615398 1.8744091862817611 up GK(ub)ENQLQLSCFINQEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKENQLQLSCFINQEVK 17 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 19670300.0 4224900.0 2025400.0 13420000.0 True False 3513191.5448049516 2014488.7681895758 16226059.952930717 1.0 0.5734070410047676 4.6186095309618445 21.744350806062883 -6.880835200871536 1.0750907782499317 0.7325448862146083 4.9099675448064115 0.9743545746118049 0.29061809360399726 0.12689462126856793 0.26781586159182735 0.20806859524859017 0.5042645779820168 1.3157240073932392e-07 6.880835200871536 4.177422658591803 up GK(ub)EVAGGQDGIGEEVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKEVAGGQDGIGEEVLK 17 1 E9PMD8 E9PMD8 PSMC3 1 6438400.0 3141100.0 1834200.0 1463100.0 True False 3041387.499851208 2566605.6252266373 1079870.2179408455 1.0 0.8438930012542636 0.3550584126467526 21.536298209599025 -6.950483223454243 0.5535152229966731 1.006623806101658 0.16922405763489862 0.9992386471179208 0.00758045874133153 0.08329232227374805 0.03516410055955292 0.00819098388101412 0.04058057951292711 1.120770720027977e-07 6.950483223454243 -0.8373997484667592 down GK(ub)EVAGGQDGIGEEVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKEVAGGQDGIGEEVLK 17 1 E9PMD8 E9PMD8 PSMC3 1 9070500.0 3141100.0 4463500.0 1465900.0 True False 2611963.824324081 4439454.239564616 1772412.9124442001 1.0 1.699661457108216 0.6785748316797081 21.3167034850333 -6.722289534991618 1.7510488981252368 1.4246333374656817 0.6799627516550116 0.5232299946184642 0.2943424705831358 0.35093146245657064 2.1040838593978273 0.13340517591430415 0.33400196962489354 1.8954418487006028e-07 6.722289534991618 -0.74467058581067 GK(ub)EVDNFVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKEVDNFVDK 10 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 18904350.0 5557000.0 4977800.0 8369550.0 True False 5380596.076748016 6965461.49888407 6177313.773882037 1.0 1.2945520160833057 1.1480723856185744 22.35933457655448 -10.182924601819373 4.398892666353248 0.9999436649908282 1.2213122008576143 0.7526987892813254 0.059800058747578 6568525.968208393 15301373.496658316 2126.3012448555123 0.02047115174104126 6.562591900483484e-11 10.182924601819373 0.22136853586678606 GK(ub)EVDNFVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKEVDNFVDK 10 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 19725700.0 5557000.0 9895900.0 4272800.0 True False 4620891.716840898 9842588.822517633 5166222.72480495 1.0 2.1300193611216196 1.1180142365112316 22.139739851988757 -6.61976298292873 2.1179589208322764 1.7499504310470786 1.1219036483026272 0.0818163670991181 0.4859833688866124 0.5861055593913165 4.99572955949636 0.18857910232555034 0.5387684207583792 2.4001424441284135e-07 6.61976298292873 -0.6280467827444514 GK(ub)FEDMAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKFEDMAK 8 1 Q5T7C4;P09429;B2RPK0;P23497 Q5T7C4;P23497 HMGB1;HMGB1P1;SP100 High mobility group protein B1;Putative high mobility group protein B1-like 1;Nuclear autoantigen Sp-100 1 3447600.0 1020200.0 1233200.0 1194200.0 True False 1337492.0796308538 1049211.3669759503 1070635.6395752807 1.0 0.7844617422074988 0.8004799848016856 20.35109891750254 -10.316730986986872 5.621137443026076 1.0000299453950154 0.7924708635045901 0.9955516701578561 0.006539420155320229 2.4544745754047498e-06 2.983383215974592e-07 0.006332679082805543 0.0021105887796161993 4.82246420788039e-11 10.316730986986872 -0.20755908189042538 GK(ub)FEDMAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKFEDMAK 8 1 Q5T7C4;P09429;B2RPK0;P23497 Q5T7C4;P23497 HMGB1;HMGB1P1;SP100 High mobility group protein B1;Putative high mobility group protein B1-like 1;Nuclear autoantigen Sp-100 1 6526600.0 1332800.0 2811600.0 2382200.0 True False 1290490.9935378365 3934286.5423003067 1758230.3555318746 1.0 3.048674157356648 1.3624506984831772 20.299488642082178 -6.598098858335237 2.198063469159119 2.3794906844859662 1.3678360842334978 0.015039560974392074 0.8859348705864363 0.6461553031284595 5.897278030210996 0.3349342522860549 0.9857408493508032 2.522906418608599e-07 6.598098858335237 -1.0116546002524684 GK(ub)FEDMAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKFEDMAK 8 1 Q5T7C4;P09429;B2RPK0;P23497 Q5T7C4;P23497 HMGB1;HMGB1P1;SP100 High mobility group protein B1;Putative high mobility group protein B1-like 1;Nuclear autoantigen Sp-100 1 3412600.0 1020200.0 1248200.0 1144200.0 True False 1397395.509868351 1193050.3967545754 873963.5255387 1.0 0.8537671606422815 0.6254231671468848 20.41430897902543 -6.964580729253079 0.3651766642419232 1.0185486595834456 0.45275320744188785 0.9999042386291294 0.0015083701513093084 0.0781035290817875 0.015363371284824952 0.0030336663378434606 0.01944476886572851 1.0849738494652043e-07 6.964580729253079 -0.5657954521415578 GK(ub)FEDMAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKFEDMAK 8 1 Q5T7C4;P09429;B2RPK0;P23497 Q5T7C4;P23497 HMGB1;HMGB1P1;SP100 High mobility group protein B1;Putative high mobility group protein B1-like 1;Nuclear autoantigen Sp-100 1 6677490.0 1332800.0 4495700.0 848990.0 True False 1108282.2530512055 4471480.771773423 1026509.8837137596 1.0 4.034604686182617 0.9262170181717528 20.079893917516454 -6.651687327335187 2.0026684255552825 2.9665734395126737 0.9393443859957304 0.20081329258869274 1.2946781131184617 0.5044457186089558 3.8799321115547594 0.5239691963600049 1.4340144264708057 2.2300401009049058e-07 6.651687327335187 -2.027229053516943 GK(ub)FSEGEATLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKFSEGEATLR 11 1 P47897;P47897-2;A0A1B0GVU9;B4DDN1;A0A0U1RQQ5;A0A1B0GTT3 P47897 QARS Glutamine--tRNA ligase 1 3971120.0 517920.0 2005700.0 1447500.0 True False 678998.1355444139 1706457.3781573642 1297726.585400449 1.0 2.513198915913287 1.911237332573741 19.373048087427406 -10.205265493187365 6.2245939516070505 0.9999863016001553 2.2122181242435164 0.8439226409834553 0.24574978732329908 4.671866519735097e-05 5.9652316918997395e-06 0.2379488902863424 0.0793154028030947 6.233536500190668e-11 10.205265493187365 1.212231822643361 GK(ub)FTPSPVDFTITPETLQNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKFTPSPVDFTITPETLQNVK 21 1 A8MTY9;O14972;O14972-2;A8MY26 A8MTY9 DSCR3 Down syndrome critical region protein 3 1 10890200.0 3075600.0 6188800.0 1625800.0 True False 4032141.3841527654 5265455.163753452 1457577.8117748199 1.0 1.3058706682379468 0.36148975765171154 21.94311479611833 -6.819510395362333 1.373997931928483 1.1649457619712889 0.3410902338704119 0.8832477859568859 0.1344322979990513 0.19412188930608706 0.720241030604552 0.07688800552622295 0.17723745025865256 1.5152685334843328e-07 6.819510395362333 -0.823855528100877 down GK(ub)FTPSPVDFTITPETLQNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKFTPSPVDFTITPETLQNVK 21 1 A8MTY9;O14972;O14972-2;A8MY26 A8MTY9 DSCR3 Down syndrome critical region protein 3 1 26932100.0 11789000.0 11140000.0 4003100.0 True False 11414764.647972353 15588260.09433254 2954568.0195741924 1.0 1.365622557719711 0.2588374014438417 23.444397778289833 -6.817681354153034 1.381887000759979 1.1975408097505498 0.23585730270564362 0.8789686866217357 0.16018210062462634 0.1965090339943576 0.7379775980896197 0.09110417759292729 0.21012030732497944 1.52166357878703e-07 6.817681354153034 -0.9616835070449061 down GK(ub)FTPSPVDFTITPETLQNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKFTPSPVDFTITPETLQNVK 21 1 A8MTY9;O14972;O14972-2;A8MY26 A8MTY9 DSCR3 Down syndrome critical region protein 3 1 12919100.0 3075600.0 6773100.0 3070400.0 True False 4212732.434964809 6473842.046353479 2345234.7568729427 1.0 1.5367323100375252 0.5567015691307567 22.00632485764122 -6.758008458252662 1.6200532275763857 1.3125343509811436 0.5534793122072488 0.6827627623424445 0.22569038753335766 0.2862702636355406 1.480361992512833 0.10994366129654942 0.2647250508400468 1.745788151887352e-07 6.758008458252662 -0.7590550387738948 GK(ub)FTPSPVDFTITPETLQNVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKFTPSPVDFTITPETLQNVK 21 1 A8MTY9;O14972;O14972-2;A8MY26 A8MTY9 DSCR3 Down syndrome critical region protein 3 1 24955100.0 11789000.0 10500000.0 2666100.0 True False 9803075.841251997 10443434.415913178 3223569.1833463954 1.0 1.065322209583089 0.32883242316471745 23.22480305372411 -6.885269787732781 1.0499377806825816 1.0441749304117909 0.2710553573011256 0.9776947886899431 0.04971210860725248 0.12306594535563052 0.24492823277382783 0.03628134129835542 0.08904098122280774 1.3023574906395934e-07 6.885269787732781 -0.7731195731106653 down GK(ub)GDTFVDCTGADIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKGDTFVDCTGADIK 15 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 10672700.0 3030400.0 2390400.0 5251900.0 True False 3972883.746435346 2033761.6377062222 4708483.767782129 1.0 0.5119106844067629 1.1851551840666865 21.921755147573982 -6.71225921064613 1.7873035569350002 0.7006273807085435 1.1836712243596303 0.4757751668132538 0.2056068495875618 0.3705430182867535 2.308787479763352 0.09150138243719876 0.23180871497346564 1.9397277966247604e-07 6.71225921064613 0.4830438436510869 GK(ub)GDTFVDCTGADIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKGDTFVDCTGADIK 15 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 80708100.0 3489100.0 24034900.0 53184100.0 True False 5293219.787377592 19745684.309469175 42672239.32358092 1.0 3.730373024856339 8.061679098483445 22.335714128752567 -6.9643104233289 0.3696959029234913 0.6657690387789895 11.276977393020562 0.9998982177510806 0.0293330372494398 0.07819575517836243 0.01568978750316989 0.057116385150904676 0.3679153004309469 1.085649349978655e-07 6.9643104233289 10.611208354241572 GK(ub)GDTFVDCTGADIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKGDTFVDCTGADIK 15 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 12808500.0 3030400.0 2032500.0 7745600.0 True False 4150820.773480741 1942697.4294213054 5916248.805639351 1.0 0.46802729759690964 1.425320226649579 21.984965209096874 -6.755852224894744 1.6278346896557039 0.6894125220572174 1.4281480993174385 0.6738945027193614 0.2236376213097762 0.289947020113376 1.5132191308612088 0.10844288550278258 0.261709612646911 1.7544773871038552e-07 6.755852224894744 0.7387355772602211 GK(ub)GDTFVDCTGADIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKGDTFVDCTGADIK 15 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 52089800.0 3489100.0 17570100.0 31030600.0 True False 4516708.730443247 16592308.48964081 25383349.20084343 1.0 3.6735396236215845 5.619877374371325 22.106840450845016 -7.997216412632771 0.26131520001467345 1.4614191312988462e-18 7.248828992618662 0.9994978634962884 0.042437693447220426 0.10521012804885035 0.050213700904459424 0.42305091001956285 0.6126476473863419 1.006430031235651e-08 7.997216412632771 7.248828992618662 GK(ub)GSAVPSDGQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKGSAVPSDGQAR 13 1 Q9BWW4-2;Q9BWW4-3;Q9BWW4 Q9BWW4-2 SSBP3 Single-stranded DNA-binding protein 3 1 5174300.0 1173100.0 1654000.0 2347200.0 True False 1606826.771835487 1580920.810953425 1792839.7021014113 1.0 0.9838775645662976 1.1157641467807016 20.61578297320663 -6.876322051914685 1.100153350719193 0.9904210815511537 1.1244742072256355 0.9705934798872119 0.010073227572888897 0.13093555580998953 0.2924250221141488 0.007075229942237425 0.016960185904444532 1.329468182643676e-07 6.876322051914685 0.1340531256744818 GK(ub)IAQATDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKIAQATDR 9 1 Q8N806;H0YJY4;E9PCJ7 Q8N806 UBR7 Putative E3 ubiquitin-protein ligase UBR7 1 3224510.0 948110.0 1240700.0 1035700.0 True False 1242981.3915102992 1055592.3962107222 928535.699135922 1.0 0.849242316434128 0.7470230089347466 20.245373267503176 -7.449227134741746 0.05416652854081229 1.6421849787334792 3.026201837453775e-07 0.9999998167633452 4.410321624100127e-05 0.12952719110632904 0.004177264735740017 0.05629556121245317 0.06913308736753726 3.554453730599316e-08 7.449227134741746 -1.6421846761132954 GK(ub)IAQATDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKIAQATDR 9 1 Q8N806;H0YJY4;E9PCJ7 Q8N806 UBR7 Putative E3 ubiquitin-protein ligase UBR7 1 3378800.0 1090100.0 1231200.0 1057500.0 True False 1055495.3721905728 1722824.580623183 780509.0256800249 1.0 1.632242666348822 0.7394717648644523 20.009488822540415 -6.716477834862618 1.7721395127282882 1.3860878603416782 0.7411436255372011 0.49580984506920467 0.2661707633752792 0.3621897569047599 2.221007841995242 0.11935346768014479 0.30085318051641985 1.9209770003741154e-07 6.716477834862618 -0.644944234804477 GK(ub)IAQATDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKIAQATDR 9 1 Q8N806;H0YJY4;E9PCJ7 Q8N806 UBR7 Putative E3 ubiquitin-protein ligase UBR7 1 3290310.0 948110.0 1190700.0 1151500.0 True False 1298651.8887093517 1138090.9368816467 879539.4158869182 1.0 0.8763633632510431 0.6772711174824818 20.308583329026067 -6.964051399290075 0.3739787241615915 1.0146361492090379 0.5320247225083814 0.9998922294703931 0.001380160416592727 0.07828439565639057 0.0160043017223858 0.00260938994517063 0.016873465783090593 1.0862970514067915e-07 6.964051399290075 -0.4826114267006565 GK(ub)IAQATDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKIAQATDR 9 1 Q8N806;H0YJY4;E9PCJ7 Q8N806 UBR7 Putative E3 ubiquitin-protein ligase UBR7 1 2919570.0 1090100.0 1241300.0 588170.0 True False 906466.4496181866 1234612.8705212427 711153.6276091861 1.0 1.3620061404823918 0.7845338654384083 19.789894097974692 -6.737252607986978 1.697045077597245 1.2160770163743189 0.7844127744788236 0.5924395005417535 0.1521119310548542 0.3228004960714183 1.824340999846561 0.07094486276949374 0.1746006237308541 1.8312489640420374e-07 6.737252607986978 -0.43166424189549524 GK(ub)ITFCTGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKITFCTGIR 10 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 13063900.0 3028200.0 5287300.0 4748400.0 True False 2932071.448552879 7398546.46290525 3504651.591053461 1.0 2.523317249501814 1.1952817837311498 21.483488828736213 -6.612969320874856 2.1427284126954014 2.0156862665288493 1.2001330013847749 0.05974340748113005 0.6562543420049559 0.6044686100308968 5.263379210806072 0.2525357843506078 0.7282490690245006 2.437983034567623e-07 6.612969320874856 -0.8155532651440744 GK(ub)ITFCTGIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKITFCTGIR 10 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 9513400.0 3028200.0 2923600.0 3561600.0 True False 2518082.4720060485 2907849.9865108347 4306314.0930222105 1.0 1.1547874300535816 1.7101560973066758 21.26389410417049 -6.947375290504045 0.5869621829163949 0.993520254676177 1.899222713196375 0.9989788009321147 0.009743672989746818 0.08455732614561713 0.040460086037894534 0.010133531014302526 0.046484211851669746 1.12882003643659e-07 6.947375290504045 0.905702458520198 GK(ub)LEAIITPPPAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKLEAIITPPPAK 13 1 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 230159200.0 63689200.0 115083000.0 51387000.0 True False 83497157.96709014 97913064.99002044 46069966.17891051 1.0 1.1726514695100427 0.5517549016107672 26.315223756929193 -6.832525874006788 1.3167076726349713 1.0921018016577815 0.5341827642306343 0.9108105024804053 0.07814698329850635 0.1777155121574769 0.6017010355342028 0.04658835771545578 0.10720545081632175 1.47053080283062e-07 6.832525874006788 -0.5579190374271472 GK(ub)LEAIITPPPAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKLEAIITPPPAK 13 1 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 335843000.0 114247000.0 137107000.0 84489000.0 True False 110620291.52064595 191854540.10355952 62358796.28433061 1.0 1.7343521470267702 0.5637193269617454 26.721040808243643 -6.7371284706264 1.6973697083613102 1.438384699361483 0.5634741504639569 0.5919315067026912 0.3085705099663017 0.3230276155657058 1.8262492021788468 0.14388847428656532 0.3541866716538938 1.8317724772678727e-07 6.7371284706264 -0.8749105488975262 GK(ub)LEAIITPPPAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKLEAIITPPPAK 13 1 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 320451000.0 162861000.0 115883000.0 41707000.0 True False 247072043.73394364 95202773.25198855 33463593.1691725 1.0 0.3853239395813896 0.13544062963759404 27.880356537680917 -9.666377352788933 0.2554367493612036 1.4557102266419728 1.2888766413283285e-21 0.9990301999051259 0.011313028686083871 1.0799798192647758 0.10765180229066716 0.48755751456132357 0.10578062056505637 2.1558703875620842e-10 9.666377352788933 -1.4557102266419728 GK(ub)LEAIITPPPAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKLEAIITPPPAK 13 1 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 206002600.0 63689200.0 77036300.0 65277100.0 True False 87236818.37591392 73632581.54102255 49859993.40407461 1.0 0.8440539546471184 0.571547591169842 26.378433818452084 -6.962596346746962 0.3971508770787088 1.0154589683066795 0.3902379674929105 0.9998547047546142 0.0021342395194874366 0.07878635290088576 0.017797489520757125 0.0035082134541435913 0.022856306543348286 1.0899426655055356e-07 6.962596346746962 -0.625221000813769 GK(ub)LEAIITPPPAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKLEAIITPPPAK 13 1 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 321432400.0 114247000.0 169197300.0 37988100.0 True False 95001442.50025573 168285800.5618653 45931236.07287087 1.0 1.771402582244078 0.48347935425030236 26.50144608367792 -6.744478808703231 1.6701448274859199 1.4565788303483926 0.48193787362190904 0.6249467725036464 0.3240987205745944 0.30976877501218875 1.6981775035797297 0.15340918251510635 0.37463999768204087 1.801031013181214e-07 6.744478808703231 -0.9746409567264835 GK(ub)LEEQRPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKLEEQRPER 10 2 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;E9PJF7 P13693 TPT1 Translationally-controlled tumor protein 1 16207400.0 3422100.0 6333500.0 6451800.0 True False 4486406.239663546 5388566.487789633 5784229.6260356605 1.0 1.2010875074464376 1.2892790614675687 22.097128830277278 -13.999999999999993 0.11197931363923809 0.032877803245198435 1.4465489374689489 0.9997330213772778 0.0019780235815119738 12.001134496964125 0.10186084575812045 2.6147661926643377 0.13962507263374832 1.0000000000000164e-14 13.999999999999993 1.4136711342237505 GK(ub)LEEQRPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKLEEQRPER 10 2 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;E9PJF7 P13693 TPT1 Translationally-controlled tumor protein 1 16087300.0 3422100.0 4667400.0 7997800.0 True False 4687342.848775229 4461178.834972206 6108884.359861392 1.0 0.9517500594474076 1.3032723564177946 22.16033889180017 -6.872223723204608 1.1223262874524078 0.9723105588509096 1.3247428007457749 0.9668495759219876 0.028328403606481 0.13473744681861666 0.3158560350551445 0.01956193870014179 0.04649890355917962 1.3420734250265918e-07 6.872223723204608 0.35243224189486533 GK(ub)LPIVNDCDELVAIIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKLPIVNDCDELVAIIAR 18 1 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 1 4575400.0 1963600.0 1586200.0 1025600.0 True False 2574298.61552945 1349545.1429591745 919480.75024988 1.0 0.5242379943096138 0.3571771917613266 21.295747983471646 -13.999999999999998 0.14587700091123262 3.287163499661039 0.16437007876173126 0.9995805782945413 0.005577288106035857 11.944617730588671 0.1200591783381065 7.754781660008924 0.17313748127750128 1.0000000000000041e-14 13.999999999999998 -3.1227934208993076 GK(ub)LPIVNDCDELVAIIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKLPIVNDCDELVAIIAR 18 1 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 1 16544100.0 9911600.0 3684500.0 2948000.0 True False 9596961.683335532 5155740.064413668 2175830.361895709 1.0 0.5372262841651497 0.22672075118043764 23.194146302430962 -8.265262301671534 0.2651696514346458 1.187389736665492 1.2417014970186637e-21 0.9993335245450179 0.008202406880563368 0.09547804063542487 0.06081649394029787 0.09530625945960387 0.10199550297214705 5.429223226114125e-09 8.265262301671534 -1.187389736665492 down GK(ub)LPIVNDCDELVAIIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKLPIVNDCDELVAIIAR 18 1 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 1 6744300.0 1963600.0 1239500.0 3541200.0 True False 2689595.984294741 1184734.7915216265 2704841.4933033017 1.0 0.4404880132330673 1.0056683268035733 21.358958044994537 -10.932975431844214 10.668738089475147 1.053369069020705 0.723078170018544 0.24247883699508332 0.23073389681898912 0.12867328597650454 0.0008083674474232656 0.09814528338353071 0.07446904498212373 1.1668756256622357e-11 10.932975431844214 -0.3302908990021609 GK(ub)LPIVNDCDELVAIIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKLPIVNDCDELVAIIAR 18 1 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 1 17903700.0 9911600.0 2159000.0 5833100.0 True False 8241934.558330065 2147369.038472052 7052774.24079286 1.0 0.26054186954223285 0.8557183014350279 22.97455157786524 -10.346499480235702 8.031142689947336 1.0000024942415584 0.5581300854894271 0.42360234546191844 0.2429797608446154 1.0851675451961839e-05 8.826419479201769e-07 0.23526546996860181 0.07842138060138808 4.502985202057225e-11 10.346499480235702 -0.4418724087521313 GK(ub)LPIVNEDDELVAIIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKLPIVNEDDELVAIIAR 18 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 22881100.0 6069500.0 11070000.0 5741600.0 True False 7957173.2771216165 9418399.150522038 5147514.3093162235 1.0 1.183636301801008 0.6469023772696146 22.923824585099496 -6.8143624778623 1.3960786012252586 1.0995800316343876 0.6365433029866141 0.8709061627346707 0.08002657314053607 0.2009227970517394 0.7709417145825233 0.04506145404937132 0.10404782593615192 1.5333366704034082e-07 6.8143624778623 -0.46303672864777345 GK(ub)LPIVNEDDELVAIIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKLPIVNEDDELVAIIAR 18 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 149204800.0 44347000.0 58150800.0 46707000.0 True False 42939228.75932047 81370717.69241595 34473035.5200349 1.0 1.8950204752979751 0.8028331322218293 25.35579294308647 -6.688939672116093 1.870366026635129 1.5616932647287087 0.8066783953443094 0.3653390487123195 0.3786151498715644 0.41897790163931176 2.840943875888681 0.16199654523983417 0.42238657190326134 2.046728928270541e-07 6.688939672116093 -0.7550148693843993 GK(ub)LPIVNEDDELVAIIAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKLPIVNEDDELVAIIAR 18 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 157998700.0 61496900.0 42815800.0 53686000.0 True False 93295293.32560867 35174985.96862772 43074938.56859035 1.0 0.3770285157458476 0.4617053769074403 26.475300964290895 -10.697494563019838 6.80444474886625 1.0050759836701533 0.4193669463274785 0.9842994626966751 0.034569183811066086 0.002668346504600904 0.00011862666820311491 0.03355158939156421 0.011157156099353497 2.0068062132876026e-11 10.697494563019838 -0.5857090373426748 GK(ub)LPIVNEDDELVAIIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKLPIVNEDDELVAIIAR 18 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 28662900.0 6069500.0 7801400.0 14792000.0 True False 8313558.172070146 7456708.352220103 11298434.250802703 1.0 0.8969334426829806 1.3590371315089143 22.987034646622387 -6.848165807258852 1.2438930455111985 0.9450746084568225 1.3768687843075422 0.9375988379366628 0.049477256565956106 0.15948320475978822 0.47577838252415533 0.031138988183376213 0.07197884114332188 1.4185158497632437e-07 6.848165807258852 0.4317941758507198 GK(ub)LPIVNEDDELVAIIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKLPIVNEDDELVAIIAR 18 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 125731500.0 44347000.0 45576300.0 35808200.0 True False 36876495.40520837 45330771.42571279 43295529.06158967 1.0 1.22925920501953 1.1740684299266326 25.136198218520747 -10.081804796516062 4.378153365543232 0.9999812624228867 1.201663817493061 0.9468133443198371 0.022531539646320282 2483969.9925905787 5719968.859699947 249.3592562607159 0.0077131456331110265 8.28314384701288e-11 10.081804796516062 0.2016825550701743 GK(ub)LPIVNEDDELVAIIAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKLPIVNEDDELVAIIAR 18 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 131920900.0 61496900.0 38872000.0 31552000.0 True False 79608949.3351281 36708739.028765775 25809859.750859186 1.0 0.4611132207540358 0.3242080189025981 26.246427286383344 -13.999999999999893 0.192402265534414 3.9131365961004474 0.22832997795174037 0.9994882659491048 0.006598859047282081 12.39083208079016 0.1391018220307627 13.543822399391683 0.09238386262530275 1.0000000000002453e-14 13.999999999999893 -3.684806618148707 GK(ub)NASDMPETITSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKNASDMPETITSR 14 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2;A0A075B6F6;A0A0S2Z6F0;A0A3B3IT72;Q8TCT9-4;A0A0C4DGU3 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 73650100.0 9889300.0 10034200.0 53726600.0 True False 12964968.068117438 8537136.473005246 48167486.81393844 1.0 0.6584772463882258 3.715202888342519 23.628115317142015 -6.879161539846292 1.0845082923506806 0.7906089630521806 3.928340875024848 0.9730008932342974 0.22471301223239734 0.12837336284317669 0.27682015003766397 0.159736181101402 0.3854597708508135 1.3208042574557535e-07 6.879161539846292 3.1377319119726677 up GK(ub)NASDMPETITSR ddPTM_RPMI8226_Bortezomib_2h_R1 2 GKNASDMPETITSR 14 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2;A0A075B6F6;A0A0S2Z6F0;A0A3B3IT72;Q8TCT9-4;A0A0C4DGU3 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 198510520.0 9578420.0 15564000.0 173368100.0 True False 9274358.300062038 21778786.36518777 127957793.6784844 1.0 2.3482795963405994 13.796943091753146 23.144816033338465 -6.929004740991867 0.7549230863968334 0.8193165001426278 16.08876656174461 0.9963388729898874 0.34738368822783905 0.09315804604741486 0.0802378980125858 0.31462876491524755 1.0416349153151732 1.1775931182115598e-07 6.929004740991867 15.269450061601981 GK(ub)NASDMPETITSR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GKNASDMPETITSR 14 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2;A0A075B6F6;A0A0S2Z6F0;A0A3B3IT72;Q8TCT9-4;A0A0C4DGU3 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 363852450.0 7815950.0 133384300.0 222652200.0 True False 11857367.572484005 109580829.5287075 178644895.07807413 1.0 9.241581561745527 15.066151402157278 23.49928042016113 -8.084797632797585 0.37725380472185904 3.717814198219829e-17 17.18824009703219 0.9973368823378609 0.2977978553901924 0.1031638935626583 0.09337601511303081 0.9672587855307307 1.4669020744060755 8.226258777454167e-09 8.084797632797585 17.18824009703219 GK(ub)NASDMPETITSR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GKNASDMPETITSR 14 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2;A0A075B6F6;A0A0S2Z6F0;A0A3B3IT72;Q8TCT9-4;A0A0C4DGU3 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 105334810.0 11298200.0 10275410.0 83761200.0 True False 15475449.862374622 9821408.40996308 63978529.6760637 1.0 0.6346444528143779 4.134195144246783 23.88347801257086 -6.8811177302448145 1.0735172092230445 0.7700166653009531 4.387612744293042 0.974577102719141 0.2504391211195072 0.12664588587579031 0.2663267346759488 0.1795192158198469 0.43539328245432773 1.314868344227791e-07 6.8811177302448145 3.617596078992089 up GK(ub)NASDMPETITSR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GKNASDMPETITSR 14 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2;A0A075B6F6;A0A0S2Z6F0;A0A3B3IT72;Q8TCT9-4;A0A0C4DGU3 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 118180620.0 9578420.0 28021800.0 80580400.0 True False 7964880.625953428 27870841.001508188 97429389.07832636 1.0 3.4992164114414375 12.232372794245572 22.92522130877274 -6.947981123845288 0.580584986487358 0.8958361409693801 15.268143230914855 0.9990331792228473 0.1497243582699307 0.0843066959825001 0.03939655578734448 0.15677289200102035 0.7296474169555511 1.1272464496968684e-07 6.947981123845288 14.372307089945476 GK(ub)NASDMPETITSR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GKNASDMPETITSR 14 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2;A0A075B6F6;A0A0S2Z6F0;A0A3B3IT72;Q8TCT9-4;A0A0C4DGU3 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 259118550.0 7815950.0 85296000.0 166006600.0 True False 10117901.350407824 80549202.61879009 135795102.17155764 1.0 7.961058309344297 13.421271612426239 23.27040674225358 -7.921026137646119 0.3544835457384435 6.984527078999465e-14 15.959338720702105 0.9981745806543473 0.21718305880417638 0.11613829273009131 0.07492276029843185 0.7361728378766319 1.3677390697120497 1.1994271144705413e-08 7.921026137646119 15.959338720702036 GK(ub)NCELLLVVPEEVEAHQSWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKNCELLLVVPEEVEAHQSWR 21 1 Q15040;H0YGT9 Q15040 JOSD1 Josephin-1 1 150696300.0 23993300.0 82130000.0 44573000.0 True False 31455448.6514477 69876524.14023258 39961013.534407124 1.0 2.2214442055658488 1.2704003677457631 24.906806603782638 -10.272903682930954 4.834996981861623 0.9997723932779484 1.7459222866567112 0.4506127108773049 0.38826202094936213 0.0009528780739907485 0.0001432961039366909 0.37604532271575813 0.1253110284246988 5.334531906831779e-11 10.272903682930954 0.7461498933787628 GK(ub)NCELLLVVPEEVEAHQSWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKNCELLLVVPEEVEAHQSWR 21 1 Q15040;H0YGT9 Q15040 JOSD1 Josephin-1 1 242169100.0 121932000.0 69005000.0 51232100.0 True False 118061335.40220252 96559056.35632114 37812876.07994481 1.0 0.8178719648339652 0.3202816226932106 26.814961324540462 -6.953532723396147 0.5186136340901075 1.0085468577117733 0.10745354372481006 0.9994501438248047 0.006736500762038494 0.08209745569429813 0.030326019465180886 0.0076485455041818 0.04109573630081799 1.1129285322536031e-07 6.953532723396147 -0.9010933139869632 down GK(ub)NCELLLVVPEEVEAHQSWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKNCELLLVVPEEVEAHQSWR 21 1 Q15040;H0YGT9 Q15040 JOSD1 Josephin-1 1 957702000.0 288520000.0 393878000.0 275304000.0 True False 437705933.63737994 323587393.5171398 220890043.72997016 1.0 0.7392803447467488 0.5046539851410098 28.70538670069797 -6.9723769674507245 0.1931541168120697 1.1526092822039873 0.0848942519103306 0.9999954721370712 0.0004304685067125256 0.07553872616728337 0.006185105396965305 0.00806465464823489 0.025357474192949887 1.0656707178719054e-07 6.9723769674507245 -1.0677150302936567 GK(ub)NCELLLVVPEEVEAHQSWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKNCELLLVVPEEVEAHQSWR 21 1 Q15040;H0YGT9 Q15040 JOSD1 Josephin-1 1 177968300.0 23993300.0 57905000.0 96070000.0 True False 32864271.404552326 55346565.63377157 73380244.62375714 1.0 1.6840953189701633 2.232827368069769 24.97001666530553 -6.973623046193576 0.14791887273882418 0.3432140805966479 3.5881154035583975 0.9999986314426148 0.0005899405282200914 0.07514360843919374 0.0045123448633408204 0.028595409853171053 0.06904384353242511 1.0626174752367235e-07 6.973623046193576 3.24490132296175 GK(ub)NCELLLVVPEEVEAHQSWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKNCELLLVVPEEVEAHQSWR 21 1 Q15040;H0YGT9 Q15040 JOSD1 Josephin-1 1 286163800.0 121932000.0 41244800.0 122987000.0 True False 101391860.50348112 41022606.07594824 148703013.07236144 1.0 0.4045946673849603 1.4666168697758137 26.59536659997474 -6.75457093067015 1.6329088494536965 0.6518320296274815 1.4694897560533375 0.6684246335391526 0.2502712346803976 0.29213095785429616 1.5338464028567196 0.12100662032510394 0.2923778260109754 1.7596612455871164e-07 6.75457093067015 0.817657726425856 GK(ub)NCELLLVVPEEVEAHQSWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKNCELLLVVPEEVEAHQSWR 21 1 Q15040;H0YGT9 Q15040 JOSD1 Josephin-1 1 726751000.0 288520000.0 303761000.0 134470000.0 True False 373494827.5794575 286856433.3226213 109997839.77871563 1.0 0.7680332152969247 0.29450967364551955 28.47651302279042 -6.9596426297097915 0.4404409822229782 1.0168535491845305 0.027213806062763905 0.9997567155227739 0.004579271759623382 0.07982902351890692 0.021604837625234796 0.006246560824013554 0.0392311274947927 1.0973808325180169e-07 6.9596426297097915 -0.9896397431217666 down GK(ub)NCVAIAADR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKNCVAIAADR 11 1 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 21308400.0 6270800.0 7706800.0 7330800.0 True False 8221079.526513573 6556975.480871111 6572279.137999045 1.0 0.7975808359138716 0.7994423502172643 22.97089641886236 -10.542366737843968 9.03087331258275 1.0000148395950197 0.7985115930655683 0.9999359836137379 0.0007599600320340794 2.2707851379412372e-07 1.1506830886872406e-08 0.0007358822576352905 0.00024527604565427035 2.8683573887212298e-11 10.542366737843968 -0.2015032465294514 GK(ub)NCVAIAADR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKNCVAIAADR 11 1 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 26002300.0 5911800.0 8203200.0 11887300.0 True False 5724133.144955711 11478780.539122881 8773659.51864412 1.0 2.005330807030292 1.5327490287984913 22.448625799273678 -10.179343231986001 4.743529650015774 0.9999015673786876 1.769039917918592 0.779292164423832 0.19293070308193125 0.00020086243872435055 3.4750403200115634e-05 0.186828039166809 0.062268116665321324 6.616933469468324e-11 10.179343231986001 0.7691383505399044 GK(ub)NCVAIAADR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKNCVAIAADR 11 1 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 28143300.0 3081300.0 5953000.0 19109000.0 True False 4674557.37320414 4890640.63899871 15332097.774227751 1.0 1.0462253960199994 3.2799036465175484 22.15639833417145 -6.911370767267205 0.8863347893105848 0.9338027058142101 3.577209074353335 0.9914289401210792 0.09850780789874236 0.10351892685158627 0.13389719947833423 0.08120021994072567 0.22634039780306506 1.2263917850098836e-07 6.911370767267205 2.6434063685391247 up GK(ub)NCVAIAADR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKNCVAIAADR 11 1 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 16018700.0 6270800.0 5211700.0 4536200.0 True False 8589284.221998082 4981429.861212804 3464842.98597155 1.0 0.5799586708814252 0.4033913532745504 23.03410648038525 -13.999999999999984 0.11868656552612857 3.004082304511296 0.11652662806696826 0.9996994103796747 0.004338429901779645 11.968985654205682 0.10585414516492318 5.6678634376595 0.25454518247480373 1.0000000000000368e-14 13.999999999999984 -2.887555676444328 GK(ub)NCVAIAADR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKNCVAIAADR 11 1 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 21979300.0 5911800.0 9604300.0 6463200.0 True False 4915923.63714594 9552559.729595711 7814625.23753964 1.0 1.9431871678018342 1.5896555386846105 22.229031074707954 -10.15835329912506 4.668843710987196 0.9999098571567232 1.7664213532508513 0.8623800700747831 0.14432868323821876 101045679.90950708 17.08521329410305 97925.16668426219 0.04940754718643846 6.944591443195504e-11 10.15835329912506 0.766511496094128 GK(ub)NCVAIAADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKNCVAIAADR 11 1 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 21949300.0 3081300.0 5223000.0 13645000.0 True False 3988803.5915034735 4932335.458614009 11161750.009523135 1.0 1.236545080615237 2.7982701462911614 21.9275246562639 -6.933846802351424 0.7145175011511119 0.9793025866884446 3.152723329797773 0.9972416482664372 0.04190174837543596 0.09068909619356132 0.06825343472245579 0.03908892436520984 0.13844211274902837 1.1645367480276914e-07 6.933846802351424 2.1734207431093284 up GK(ub)NCVAIAADRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKNCVAIAADRR 12 2 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 9803500.0 2239300.0 3316900.0 4247300.0 True False 2935743.9854120445 2822031.449174932 3807830.138978466 1.0 0.9612661945993386 1.297057971641904 21.485294731278874 -6.878186588379271 1.089906975916175 0.9765256631284195 1.3200389356196378 0.9721910563719381 0.025014011636581693 0.1292464638825594 0.2821205295580545 0.01770776242502293 0.04262992609237463 1.3237726731077163e-07 6.878186588379271 0.3435132724912183 GK(ub)NCVAIAADRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKNCVAIAADRR 12 2 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 11693100.0 3118200.0 3390800.0 5184100.0 True False 3019214.447816387 4744764.122788399 3826228.690333636 1.0 1.5715227271186376 1.267292786407045 21.52574180110569 -10.096057417394293 4.440922491269014 0.9999637896657758 1.419407756788215 0.7170350520578408 0.12420135331320403 18851924.9697624 21429122.678916857 6012.53796312658 0.04251742774972067 8.01572081790585e-11 10.096057417394293 0.41944396712243925 GK(ub)NCVAIAADRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKNCVAIAADRR 12 2 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 80137500.0 4076500.0 13534000.0 62527000.0 True False 6184348.532069804 11118751.95837536 50168511.04344235 1.0 1.7978857272867979 8.112173947390986 22.56019019701506 -6.930297875967055 0.7443411298828418 0.9050316526565579 9.418360496308198 0.9965964800012912 0.18559999193241455 0.09248352972485324 0.07692416852071644 0.16939084231185084 0.5704016281407818 1.1740919869055062e-07 6.930297875967055 8.51332884365164 GK(ub)NCVAIAADRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKNCVAIAADRR 12 2 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 10430500.0 2239300.0 3040400.0 5150800.0 True False 3067229.724807092 2906065.074741719 3934287.1240558783 1.0 0.9474559571583738 1.2826842059582995 21.548504792801765 -6.866841065999771 1.1507532713477433 0.9707843688026864 1.3011669275480104 0.9614232501772755 0.028914364946218418 0.13991549861185681 0.34828189559392014 0.019536086500810203 0.04601273600039612 1.3588106246667038e-07 6.866841065999771 0.3303825587453241 GK(ub)NCVAIAADRR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKNCVAIAADRR 12 2 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 11768000.0 3118200.0 4214900.0 4434900.0 True False 2592921.459682074 4192193.4971078495 5362217.085339225 1.0 1.6167838333297868 2.0680214070181298 21.306147076539965 -7.092363585934736 0.10802078006031503 8.617710816633079e-11 3.643217052341119 0.9999996210086964 0.0002694333755551944 0.07623480903763401 0.003567632700847914 0.04232074773318402 0.07608301965371325 8.084188176237986e-08 7.092363585934736 3.6432170522549416 GK(ub)NCVAIAADRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKNCVAIAADRR 12 2 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 50767500.0 4076500.0 12607000.0 34084000.0 True False 5277109.609828292 11905409.367556345 27881061.731373176 1.0 2.256047391053476 5.283396365208411 22.33131651910751 -6.956240615468212 0.4855255256924308 0.9309819323527936 6.7358653496706085 0.9996043625023017 0.035760137804811305 0.08107241493732051 0.026308967634034827 0.0431745914761617 0.24969555499877616 1.1060108426150369e-07 6.956240615468212 5.804883417317815 GK(ub)NYTEEEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKNYTEEEDR 10 1 O60264;A0A0A0MRP6;B7ZLQ5;P28370-2;P28370 O60264 SMARCA5;SMARCA1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Probable global transcription activator SNF2L1 1 3856470.0 2443000.0 1021000.0 392470.0 True False 3202796.6580456537 868670.7798268289 351860.96923807624 1.0 0.27122258219068196 0.10986053964873992 21.610900775260216 -13.999999999999806 0.21186833546299316 5.2474825557422635 0.01652210460402595 0.9994911429884153 0.008735009416386295 12.791088018659895 0.14587984737001106 22.636670005716855 0.09434706217156578 1.0000000000004459e-14 13.999999999999806 -5.2309604511382375 GK(ub)NYTEEEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKNYTEEEDR 10 1 O60264;A0A0A0MRP6;B7ZLQ5;P28370-2;P28370 O60264 SMARCA5;SMARCA1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Probable global transcription activator SNF2L1 1 3742610.0 2443000.0 899800.0 399810.0 True False 3346243.119592611 860043.8607593055 305383.11234541785 1.0 0.2570177449820238 0.09126148382864564 21.674110836783107 -13.999993692186974 0.21349401852705252 5.368837528900719 3.2802971407410943e-09 0.9994787067929165 0.00902203997519965 12.97319486519652 0.14805201590224573 23.814043453030216 0.09526285676448684 1.00001452438172e-14 13.999993692186974 -5.368837525620422 GK(ub)PVEKCPLSGACYSPEFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKPVEKCPLSGACYSPEFK 19 2 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 12945600.0 2900600.0 3372700.0 6672300.0 True False 4400422.262264605 2770815.3339746264 5353516.98042702 1.0 0.6296703290807987 1.216591649927687 22.069210539993453 -6.736180682359107 1.7007600965452085 0.7786838956774774 1.2166512850984308 0.5876312198471729 0.15561718051747528 0.3247759232323351 1.84307341040216 0.07243082591991071 0.17848384410693888 1.8357744352694994e-07 6.736180682359107 0.43796738942095337 GK(ub)QAEVANQETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKQAEVANQETK 12 1 A6NEL0;P05114;A6NL93 A6NEL0 HMGN1 Non-histone chromosomal protein HMG-14 1 6106330.0 3021000.0 2190600.0 894730.0 True False 3960560.255405618 1863771.0188919199 802151.9224561962 1.0 0.47058266979984203 0.2025349624112825 21.9172730957209 -9.169860473866537 0.23156904079445356 1.3761140154609508 2.9004133742799794e-16 0.9992983066549277 0.00877705850301969 0.6026930055334109 0.08248528109013745 0.29639680761322945 0.12242958364718699 6.763002160016316e-10 9.169860473866537 -1.3761140154609506 GK(ub)QAEVANQETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKQAEVANQETK 12 1 A6NEL0;P05114;A6NL93 A6NEL0 HMGN1 Non-histone chromosomal protein HMG-14 1 6301730.0 2679000.0 2950300.0 672430.0 True False 2593956.6114104628 4128370.175611246 496300.41053240607 1.0 1.5915340131176854 0.19132949577847524 21.306722917446372 -6.791921484854044 1.4885551718873564 1.3297820558318956 0.1756195762307207 0.8075219901041588 0.251790961696373 0.2324960288610421 1.017655550911668 0.1331250264928296 0.3112601134657887 1.614650439549519e-07 6.791921484854044 -1.154162479601175 GK(ub)QAEVANQETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKQAEVANQETK 12 1 A6NEL0;P05114;A6NL93 A6NEL0 HMGN1 Non-histone chromosomal protein HMG-14 1 5877600.0 3021000.0 1797800.0 1058800.0 True False 4137945.339455294 1718367.2514704152 808733.2466704899 1.0 0.4152706501668327 0.1954431922914064 21.980483157243793 -11.312668829027494 0.18318770918876176 2.1402700746259793 1.024669983800063e-22 0.9994564792909391 0.00791571186450708 3.7403720637533158 0.10851325723929285 1.8853293435513594 0.15453481464073462 4.86778256641683e-12 11.312668829027494 -2.1402700746259793 GK(ub)QAEVANQETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKQAEVANQETK 12 1 A6NEL0;P05114;A6NL93 A6NEL0 HMGN1 Non-histone chromosomal protein HMG-14 1 5039700.0 2679000.0 2360700.0 0.0 True False 2227707.1998230643 2347982.4405377363 0.0 1.0 1.053990596575809 0.0 21.087128192880648 -6.986402551209441 1.1429892917872353 1.040594654038301 9.95186214384602e-19 0.9809654943983414 0.06686250411872813 0.09527625529251184 0.24471499729818008 0.04914477620320074 0.09090432980101124 1.031804574040909e-07 6.986402551209441 -1.040594654038301 down GK(ub)QGGPTYYIDTNALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKQGGPTYYIDTNALR 16 1 O96019;O96019-2;H7C5S0;C9JQT2 O96019 ACTL6A Actin-like protein 6A 1 19535200.0 7974500.0 7481600.0 4079100.0 True False 10454646.725167857 6365374.443048393 3657033.8614901435 1.0 0.6088560054090391 0.34979985049962814 23.317640976597236 -8.311608473616802 0.18695895187933553 1.3138328413701916 2.8636363639432566e-06 0.9998142767084068 0.0036422598136950013 0.09594676733315337 0.04159365808462889 0.12404621616235595 0.12278683911569031 4.8796820633675515e-09 8.311608473616802 -1.3138299777338276 down GK(ub)QGGPTYYIDTNALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKQGGPTYYIDTNALR 16 1 O96019;O96019-2;H7C5S0;C9JQT2 O96019 ACTL6A Actin-like protein 6A 1 22475900.0 10028000.0 7250700.0 5197200.0 True False 9709666.629049677 10145942.321900992 3835897.4073420544 1.0 1.0449320980337318 0.3950596404479737 23.21099033243793 -6.890324387225191 1.020434402639645 1.0346472358986356 0.3388022983287925 0.9811060667954002 0.04073217047884122 0.11888142934113322 0.22030012525615703 0.030400603970068434 0.07588023593322506 1.2872876797699786e-07 6.890324387225191 -0.6958449375698431 down GK(ub)QGGPTYYIDTNALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKQGGPTYYIDTNALR 16 1 O96019;O96019-2;H7C5S0;C9JQT2 O96019 ACTL6A Actin-like protein 6A 1 22510700.0 9416400.0 5365200.0 7729100.0 True False 14285367.231051661 4407738.141501068 6201439.997215128 1.0 0.30854916574493824 0.4341113460307306 23.768034788032708 -9.420025369901083 12.150100076004833 1.0000005925078796 0.371330246236168 0.9709510017549805 0.05126054544973214 0.0 0.0 0.04963280971056531 0.016544269903521765 3.801671876901014e-10 9.420025369901083 -0.6286703462717116 GK(ub)QGGPTYYIDTNALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKQGGPTYYIDTNALR 16 1 O96019;O96019-2;H7C5S0;C9JQT2 O96019 ACTL6A Actin-like protein 6A 1 20526100.0 7974500.0 6660000.0 5891600.0 True False 10922888.15275943 6365739.178325164 4500125.421310781 1.0 0.5827890104978323 0.4119904331505877 23.380851038120127 -13.999999999999998 0.1227984273806464 2.9851071258396478 0.14938778789938523 0.9996793282600124 0.004422744910513667 11.953881142433874 0.10819770743082278 5.7706856425414665 0.23310061771260623 1.0000000000000041e-14 13.999999999999998 -2.8357193379402625 GK(ub)QGGPTYYIDTNALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKQGGPTYYIDTNALR 16 1 O96019;O96019-2;H7C5S0;C9JQT2 O96019 ACTL6A Actin-like protein 6A 1 26064500.0 10028000.0 11755000.0 4281500.0 True False 8338726.315724398 11691673.481815174 5176741.854580699 1.0 1.4020934419886282 0.6208072622336672 22.991395607872207 -6.766793351472404 1.5865339525101558 1.2315683407246347 0.6169141418051951 0.7182388656181647 0.1693312989688829 0.27163442906826646 1.348820193469694 0.08414960058222325 0.20092182682120638 1.7108291781414895e-07 6.766793351472404 -0.6146541989194396 GK(ub)QGGPTYYIDTNALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKQGGPTYYIDTNALR 16 1 O96019;O96019-2;H7C5S0;C9JQT2 O96019 ACTL6A Actin-like protein 6A 1 23986700.0 9416400.0 6522600.0 8047700.0 True False 12189715.424993776 6159611.576173786 6583101.176375174 1.0 0.5053121718940319 0.5400537212605631 23.539161110125157 -10.079975905622838 5.445279082921006 1.0000046667963827 0.5226829465770357 0.9960424750842722 0.01418317813787203 8.035742943229092e-07 1.35742360671719e-07 0.01373293737343713 0.004577601060222738 8.318099180991953e-11 10.079975905622838 -0.47732172021934693 GK(ub)QMEDGHTLFDYEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKQMEDGHTLFDYEVR 16 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 17597200.0 2861500.0 9232800.0 5502900.0 True False 2770663.2488059066 12919505.18841593 4061525.4065386425 1.0 4.662964795156519 1.465903663423936 21.40179994315296 -6.6132343230062975 2.1414301854956364 3.441838579595435 1.4775313490849442 0.06067049626949694 1.5779116820447112 0.6037607586506466 5.251082088146954 0.6074402686737671 1.7512713806267821 2.436495855580436e-07 6.6132343230062975 -1.9643072305104907 GK(ub)QMEDGHTLFDYEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKQMEDGHTLFDYEVR 16 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 24487500.0 9174500.0 8024900.0 7288100.0 True False 13918387.245792806 6592793.89617012 5847603.840512297 1.0 0.47367513058403826 0.4201351591420829 23.730488716828326 -13.999999999999998 0.32299895590658134 6.493857861038849 0.4098579810287861 0.9997001308566771 0.004530849378144008 18.249046714267063 0.18138477418205787 67.85866844610561 0.017618931290278143 1.0000000000000041e-14 13.999999999999998 -6.083999880010063 GK(ub)QMEDGHTLFDYEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKQMEDGHTLFDYEVR 16 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 13619660.0 2861500.0 9820400.0 937760.0 True False 2379464.035943892 9767495.55600323 1133841.2802876555 1.0 4.104914135476157 0.47651120721304807 21.182205218587235 -6.680169807660017 1.9014413998213224 2.9642739794675355 0.4903903243256989 0.32476546853558275 1.315898722293931 0.4381890224253589 3.0632102029221966 0.5552994087332143 1.464162003418302 2.088479382881652e-07 6.680169807660017 -2.4738836551418366 GK(ub)QMEDGHTLFDYEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKQMEDGHTLFDYEVR 16 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 28201200.0 9174500.0 9343100.0 9683600.0 True False 11876571.106431898 8823148.271755034 7921284.16212665 1.0 0.7429036708226968 0.6669672661528364 23.501615038920775 -13.999999999999998 0.17094696418793595 2.2997895210004584 0.6006535058652875 0.9995119020374583 0.003148405739327146 12.100894819200601 0.13094728436876443 5.21618262109359 0.06138041215515027 1.0000000000000041e-14 13.999999999999998 -1.6991360151351709 GK(ub)QSLETICLLLAYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKQSLETICLLLAYK 15 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62140;E7ETD8;C9J9S3;C9JP48;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 84694000.0 10009000.0 30969000.0 43716000.0 True False 15184384.755914802 25442339.98809861 35075513.43859653 1.0 1.6755594906924371 2.3099726464013304 23.85608511848098 -6.971884046793342 0.2083303322930403 0.6606902363124887 3.342519169075016 0.9999935869471331 0.0013545232601907048 0.07569597504670984 0.006797206084696667 0.019252042841344106 0.06599690463122743 1.0668809320147533e-07 6.971884046793342 2.681828932762527 GK(ub)QSLETICLLLAYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKQSLETICLLLAYK 15 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62140;E7ETD8;C9J9S3;C9JP48;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 66162000.0 10009000.0 21914000.0 34239000.0 True False 12956847.806886151 20694466.636045806 28007853.321807463 1.0 1.597183739786413 2.161625554243385 23.62721144057343 -6.971807856318757 0.2105768799657932 0.7066481490974282 3.067928425477914 0.9999932599722494 0.0012313289728362882 0.07572033127777889 0.006890270148370464 0.016825268059523675 0.05841205260261554 1.0670681167443803e-07 6.971807856318757 2.361280276380486 GK(ub)SALLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKSALLER 8 1 Q8IUR0;M0QZQ8 Q8IUR0 TRAPPC5 Trafficking protein particle complex subunit 5 1 16196500.0 4311100.0 7848600.0 4036800.0 True False 5651893.848751785 6677619.4736031825 3619110.6597198923 1.0 1.1814835261065506 0.6403359221828218 22.43030293922152 -6.816270159527723 1.3879334347611243 1.0982051496525136 0.629442050465978 0.8755734396579119 0.0793241683643605 0.1983844696973231 0.7519055404314999 0.0449228733513233 0.10365705952226675 1.5266161078940592e-07 6.816270159527723 -0.4687630991865356 GK(ub)SALLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKSALLER 8 1 Q8IUR0;M0QZQ8 Q8IUR0 TRAPPC5 Trafficking protein particle complex subunit 5 1 21768100.0 5775800.0 8853300.0 7139000.0 True False 5592450.390513071 12388468.859349577 5269081.734590737 1.0 2.2152130093751294 0.9421776442628994 22.415049122811837 -6.656722374109496 1.9846324595902551 1.7843276368417154 0.9475224319314215 0.22171342174981779 0.5178199151680362 0.49226763383505073 3.7237935394689416 0.21105910547764084 0.5738034754349435 2.2043351499460052e-07 6.656722374109496 -0.8368052049102939 GK(ub)SALLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKSALLER 8 1 Q8IUR0;M0QZQ8 Q8IUR0 TRAPPC5 Trafficking protein particle complex subunit 5 1 13204800.0 4311100.0 4807100.0 4086600.0 True False 5905030.173096888 4594706.42704608 3121429.2461688956 1.0 0.7781004147920196 0.5286051306545424 22.49351300074441 -6.96960504925011 0.2674493031797496 1.063972182262726 0.23525822189458304 0.999979136099916 0.0008795196138658252 0.0764310679587078 0.009487677536039183 0.0049681940583906495 0.02328693296364433 1.0724941963738758e-07 6.96960504925011 -0.8287139603681429 GK(ub)SALLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKSALLER 8 1 Q8IUR0;M0QZQ8 Q8IUR0 TRAPPC5 Trafficking protein particle complex subunit 5 1 25738800.0 5775800.0 15526000.0 4437000.0 True False 4802833.611324386 15442358.356330281 5364756.185629922 1.0 3.2152599082173987 1.116998134805379 22.195454398246113 -6.633440380979453 2.068313627494748 2.4557917216061957 1.1255959593188094 0.12992355320626991 0.9494086166370672 0.5500732964825411 4.488957346928638 0.37488687152551403 1.0513516808006225 2.325731735454043e-07 6.633440380979453 -1.3301957622873863 GK(ub)SALLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKSALLER 8 1 Q8IUR0;M0QZQ8 Q8IUR0 TRAPPC5 Trafficking protein particle complex subunit 5 1 13294000.0 4061200.0 2683900.0 6548900.0 True False 5257303.458220204 2534538.6056622895 5357067.3973885 1.0 0.4820985940424155 1.018976256546939 22.32589158082404 -10.93593845083121 12.275710946259617 1.0407947559956536 0.7505374252946846 0.22352509632599804 0.21917938790570649 0.12235187806594358 0.0006384997353670221 0.10610680568150736 0.07073984326589472 1.1589415922673356e-11 10.93593845083121 -0.29025733070096904 GK(ub)SLKDEDVLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKSLKDEDVLQK 12 2 Q9NZ01;M0R2N5 Q9NZ01 TECR Very-long-chain enoyl-CoA reductase 1 35945800.0 1227800.0 13297000.0 21421000.0 True False 1862662.3642034356 10924046.460064802 17187129.960842166 1.0 5.864748582460597 9.227184857086117 20.828934756950858 -8.129684385722586 0.331700266891812 1.577301616716695e-22 10.87488517403921 0.9984541036436537 0.13279019942969086 0.09695634083636444 0.07785651766779209 0.6832935837842042 0.9232237169636938 7.418491685545849e-09 8.129684385722586 10.87488517403921 GK(ub)SLKDEDVLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKSLKDEDVLQK 12 2 Q9NZ01;M0R2N5 Q9NZ01 TECR Very-long-chain enoyl-CoA reductase 1 28464800.0 1227800.0 10118000.0 17119000.0 True False 1589411.3035562804 9554924.405563178 14003517.65577328 1.0 6.011612214021757 8.810505892616122 20.600061079043307 -8.470106203315657 0.3565386319815608 2.753155357385047e-16 9.785301091176347 0.9977823856050938 0.15215265979365925 0.17171540263639506 0.10415257802260304 0.9046166200298957 0.7640567258934171 3.3876130458423667e-09 8.470106203315657 9.785301091176347 GK(ub)TPEEIRK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKTPEEIRK 9 2 E5RJR5;P63208;E7ERH2;F8W8N3;P63208-2 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 8359500.0 2453000.0 4868200.0 1038300.0 True False 2375130.857704313 6812097.647327627 766338.081667678 1.0 2.8680936148132368 0.3226508885528873 21.179575570161592 -6.70998101301265 1.7951804338830986 2.1484344326727483 0.3285734387295008 0.4651704672590855 0.7871978724344231 0.3750481903960148 2.356041626926707 0.3489567397823344 0.886565056911302 1.9499298471779033e-07 6.70998101301265 -1.8198609939432475 GK(ub)TPEEIRK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKTPEEIRK 9 2 E5RJR5;P63208;E7ERH2;F8W8N3;P63208-2 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 5288190.0 2120700.0 2477500.0 689990.0 True False 2904780.099762604 2368035.858003093 527028.5727901122 1.0 0.8152203528923319 0.1814349295608243 21.469997520909224 -7.0138882943457785 0.6067895780092538 1.0050005041227674 6.710502719336437e-23 0.9989767922493827 0.011212794557065768 0.07594039942533169 0.04134398808877506 0.011710298757648724 0.04706972649069538 9.685269407589492e-08 7.0138882943457785 -1.0050005041227674 down GK(ub)VCFEMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKVCFEMK 8 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 18787700.0 4842900.0 6320100.0 7624700.0 True False 6349088.79871032 5377165.715556844 6835769.185286917 1.0 0.8469192802357873 1.0766535800657655 22.598118125002685 -6.7270841631862455 1.7336849729921835 0.9075786804132334 1.0764497812025742 0.5457410089977892 0.06436778524852492 0.34174891117602213 2.0109309671526514 0.02943758325362786 0.07329467544335225 1.8746311826539937e-07 6.7270841631862455 0.16887110078934076 GK(ub)VCFEMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKVCFEMK 8 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 8506500.0 4826400.0 3680100.0 0.0 True False 4673188.5738377925 5149583.12146797 0.0 1.0 1.101942076614928 0.0 22.155975823743137 -6.959195043921684 1.187918255421619 1.0598412371647685 5.884215689757729e-20 0.9746996588968552 0.07908144345276455 0.10399882789334589 0.2909576983122982 0.055515203401320136 0.10472087785346858 1.0985123809817023e-07 6.959195043921684 -1.0598412371647685 down GK(ub)VCFEMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKVCFEMK 8 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 17126700.0 9978000.0 7148700.0 0.0 True False 15137355.489511246 5872958.631951973 0.0 1.0 0.3879778496330734 0.0 23.85160985134431 -8.330169358672084 0.5310346120578174 1.03613656724603 9.047707691796341e-17 0.9922436842038989 0.03625395123834441 0.15965415349996248 0.17804817391832928 0.06256619285110808 0.07044950843063522 4.675527775633362e-09 8.330169358672084 -1.03613656724603 GK(ub)VCFEMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKVCFEMK 8 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 15988000.0 4842900.0 3715000.0 7430100.0 True False 6633451.004451524 3550859.016137835 5675263.407712893 1.0 0.5352958835084413 0.8555521709445629 22.661328186525576 -10.13546833683752 5.47386637745597 1.0000056411134854 0.6954240272264306 0.546683640861755 0.13074408185635453 9.00109461114827e-06 1.4215876296831069e-06 0.1265947570505652 0.04219747097036648 7.320346917997654e-11 10.13546833683752 -0.30458161388705485 GK(ub)VCFEMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKVCFEMK 8 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 16004600.0 4826400.0 4129200.0 7049000.0 True False 4013365.445773061 4106955.180017971 8522913.309106465 1.0 1.0233195146341534 2.1236325035097243 21.936381099177414 -6.911476490870808 0.8856149597203511 0.9675021065464844 2.2704159250791958 0.99146700003317 0.04842954273979766 0.10344997835754874 0.13352941989902664 0.0399416165891052 0.11141886061819709 1.2260932714810692e-07 6.911476490870808 1.3029138185327114 up GK(ub)VCFEMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKVCFEMK 8 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 22496200.0 9978000.0 7952700.0 4565500.0 True False 12916717.695784809 7510125.25401485 3734625.845985921 1.0 0.5814267549151186 0.2891311813065841 23.62273617343676 -8.133761429733235 0.23071126439485085 1.2174596367876391 6.961882907491302e-20 0.9996615574812381 0.0053669577647315996 0.08896487521142937 0.04643106187130512 0.08705727750117116 0.10447646105971817 7.349174682852761e-09 8.133761429733235 -1.2174596367876391 down GK(ub)VEEVELPVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKVEEVELPVEK 12 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;Q99873-5;E9PNR9;H0YDE4;Q9NR22-2;Q9NR22 E9PKG1 PRMT1;PRMT8 Protein arginine N-methyltransferase 1;Protein arginine N-methyltransferase 8 1 37962800.0 4842800.0 13134900.0 19985100.0 True False 7346881.65610393 10790874.471557902 16035036.225219512 1.0 1.468769333257551 2.182563565849369 22.808700605138583 -6.965006755129562 0.357942253878786 0.9370282374638639 2.7386873259082725 0.9999132775691302 0.004527929599433927 0.07795873866428538 0.01485226566241799 0.009617690413002429 0.06104290646061151 1.0839100544705969e-07 6.965006755129562 1.8016590884444086 GK(ub)VEEVELPVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKVEEVELPVEK 12 1 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;Q99873-5;E9PNR9;H0YDE4;Q9NR22-2;Q9NR22 E9PKG1 PRMT1;PRMT8 Protein arginine N-methyltransferase 1;Protein arginine N-methyltransferase 8 1 37254200.0 4842800.0 8583800.0 23827600.0 True False 6269100.065859555 8106103.9842333775 19491221.29182215 1.0 1.2930251390271836 3.1090939827181896 22.579826927231032 -6.935153713938088 0.7032114214388908 0.9769416054519235 3.5360743621466013 0.9974575952843722 0.047037505046367376 0.0900488291669006 0.06521069999090981 0.044253036680256284 0.1599238939207992 1.1610376041293425e-07 6.935153713938088 2.5591327566946775 up GK(ub)VQFQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKVQFQGK 8 1 P05455 P05455 SSB Lupus La protein 1 2517450.0 933910.0 1020400.0 563140.0 True False 904263.5382464885 1427851.0413157027 415636.7401621273 1.0 1.5790209169381462 0.45964115833766045 19.78638376689194 -6.766109727735707 1.5892531008799764 1.3337586639925743 0.45423702123795806 0.7154880738930094 0.24380263330916682 0.2727699490158415 1.3590062782402925 0.12096127124554602 0.28898860859289455 1.7135243181295238e-07 6.766109727735707 -0.8795216427546162 down GK(ub)VVIDAFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKVVIDAFR 9 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 5825050.0 912450.0 1466800.0 3445800.0 True False 1196230.7861783681 1247959.1575416196 3089261.670447578 1.0 1.0432428022760638 2.582496376236001 20.190064321698756 -6.912912564812393 0.8756536034715272 0.9566185627046234 2.794337065373549 0.9919753118837038 0.06593270649065398 0.10252373284112413 0.12854877437299408 0.05476965388206405 0.15442387777189512 1.2220456661386642e-07 6.912912564812393 1.8377185026689253 up GK(ub)VVIDAFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKVVIDAFR 9 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 8684350.0 912450.0 1166400.0 6605500.0 True False 1249807.4230340868 1114864.5912310027 5045416.944542805 1.0 0.8920291003909298 4.0369554953469 20.253274383221648 -6.898950681634951 0.9678958761217159 0.8654542101986226 4.360102271007778 0.9860364579096523 0.17225858744307415 0.11218117073824792 0.181815984311132 0.13374172688869235 0.34617013796498686 1.2619708355239999e-07 6.898950681634951 3.4946480608091557 up GK(ub)YGCVDYWVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKYGCVDYWVK 11 1 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 10043400.0 2121900.0 2842300.0 5079200.0 True False 2781831.4485088326 2418239.9191986267 4553653.107126749 1.0 0.8692977859945091 1.6369263168577954 21.407603578792 -6.8630678048228 1.1702309466682719 0.9284300907125208 1.676319914897082 0.9572561607499617 0.06932793876466456 0.1436695936815978 0.3721440110654194 0.04614796951627632 0.10811602626769837 1.370667752072284e-07 6.8630678048228 0.7478898241845612 GK(ub)YGCVDYWVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKYGCVDYWVK 11 1 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 12409700.0 2121900.0 4297200.0 5990600.0 True False 2906423.7721913904 4107335.49505989 4575743.660279787 1.0 1.4131922310706377 1.5743552967259693 21.47081364031489 -11.771727888037919 0.16186814565325755 3.56554766730378e-19 1.7511654951869398 0.9995470555511938 0.005147962012759199 4.821002021786357 0.10481643130256797 1.7957330367965214 0.13886886131073492 1.6915004277999059e-12 11.771727888037919 1.7511654951869398 GK(ub)YGQFSGLNPGGRPITPPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKYGQFSGLNPGGRPITPPR 20 2 P62136;P62136-2;P62136-3 P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 34208100.0 4028000.0 9742100.0 20438000.0 True False 5214325.403750364 9199943.571005847 16718493.711589156 1.0 1.7643593099097457 3.2062620602014036 22.314049187435117 -6.961172008203906 0.4185888170484133 0.935288778416105 4.08959911894374 0.9998112270039468 0.012568188304880051 0.07928508155227075 0.0196038130412169 0.018636162197242217 0.12007482770272018 1.0935231758472992e-07 6.961172008203906 3.154310340527635 GKDCAVIVTQK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKDCAVIVTQKK 12 2 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 2242930.0 447140.0 719090.0 1076700.0 True False 586204.870109919 611804.5749908664 965293.4124356919 1.0 1.0436702357592955 1.6466826900545712 19.16104542822722 -6.921468524449277 0.8137602979662968 0.9873861937178553 1.7472864607097576 0.9945792592719128 0.021726570329528086 0.09731531320456299 0.10119288526346583 0.018866740403121342 0.057333282530549624 1.1982059601806254e-07 6.921468524449277 0.7599002669919023 GKDCAVIVTQK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKDCAVIVTQKK 12 2 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 1848380.0 843460.0 531080.0 473840.0 True False 816684.8239866622 743143.0135456137 349727.08910470246 1.0 0.9099508056461086 0.4282277309837878 19.639419893566753 -6.938309787302398 0.6751055425190292 1.0055978771862215 0.3045370225415862 0.997934017563488 0.011409531392114192 0.08854628446235265 0.05818517234292081 0.01096892933908862 0.041779132068674216 1.1526307795804901e-07 6.938309787302398 -0.7010608546446353 down GKDCAVIVTQK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKDCAVIVTQKK 12 2 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 2138580.0 447140.0 502040.0 1189400.0 True False 612459.74150415 479858.2127757309 908488.2164619189 1.0 0.7834934776239156 1.483343565130906 19.22425548975011 -6.823624140311469 1.3561414219334087 0.8837130967729949 1.499840198437426 0.8925132972288478 0.0959140389652723 0.1888130287049407 0.681317660868873 0.05556376661022997 0.12795739218873428 1.5009832979128015e-07 6.823624140311469 0.6161271016644312 GKDCAVIVTQK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKDCAVIVTQKK 12 2 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 4722100.0 1285900.0 1555700.0 1880500.0 True False 1664622.8988785006 1469123.9274297936 1538268.295559417 1.0 0.8825566009091791 0.9240941576592441 20.666763957709925 -10.169770556855827 6.760710389727668 1.0000002357065054 0.9033253797558904 0.8783810589829542 0.01695763653325982 6.02536104705974e-08 7.382628741966796e-09 0.01641920109594643 0.005473053657029474 6.764402527553218e-11 10.169770556855827 -0.09667485595061498 GKDPQPVEEEK(ub)SISER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKDPQPVEEEKSISER 16 2 E5RH51;Q96EX1 E5RH51 SMIM12 Small integral membrane protein 12 1 11618500.0 1743800.0 2448300.0 7426400.0 True False 2257383.4754369115 2312049.952771333 6074871.4012988405 1.0 1.0242167438227752 2.691111841386658 21.10622008803891 -6.910062893737118 0.8953083286030441 0.948492275170247 2.9068186901243016 0.9909452396394505 0.07532128026481029 0.1043763838987061 0.13854247106865733 0.061685726536818274 0.1703543857377934 1.230090618426362e-07 6.910062893737118 1.9583264149540547 up GKEDAGK(ub)AFAS ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKEDAGKAFAS 11 2 O15258 O15258 RER1 Protein RER1 1 4387800.0 1260900.0 2032500.0 1094400.0 True False 1653052.110572969 1729258.922622948 981161.9862260803 1.0 1.0461006713354999 0.5935457085415153 20.656700773978727 -6.881797820334763 1.0697654354816921 1.0293089397800388 0.560352551264868 0.9751050737193164 0.03208375651429414 0.12604751036311135 0.26278751560234437 0.02306514706431376 0.056039041485230486 1.3128109173726826e-07 6.881797820334763 -0.46895638851517074 GKEDAGK(ub)AFAS ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKEDAGKAFAS 11 2 O15258 O15258 RER1 Protein RER1 1 4208800.0 1367900.0 1482900.0 1358000.0 True False 1324476.7632506036 2075029.7032213395 1002299.0608732608 1.0 1.566678828044282 0.7567509590831654 20.336991102471355 -6.718600289120099 1.7641788880944558 1.345271738050819 0.758097141220272 0.5059718019703299 0.23850241635915373 0.3580493781680347 2.1770380921071726 0.10737186488245173 0.27000592211167673 1.9116118361343844e-07 6.718600289120099 -0.587174596830547 GKEDAGK(ub)AFAS ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKEDAGKAFAS 11 2 O15258 O15258 RER1 Protein RER1 1 3180900.0 1203900.0 1977000.0 0.0 True False 1826404.3168793935 1624188.9036284967 0.0 1.0 0.8892822299082147 0.0 20.800574743949674 -7.129038587652105 0.9588806738326803 0.9964796759721208 1.47784973441831e-19 0.9896851609546516 0.045458764210076164 0.08622528021870775 0.15025788151922578 0.03783595510101733 0.06657839386613855 7.429531225741764e-08 7.129038587652105 -0.9964796759721208 down GKEDAGK(ub)AFAS ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKEDAGKAFAS 11 2 O15258 O15258 RER1 Protein RER1 1 3210400.0 1260900.0 1111900.0 837600.0 True False 1727088.8045412696 1062772.5814384012 639776.1309134898 1.0 0.6153549132180747 0.37043615199822927 20.71991083550162 -8.533537629127254 0.16944084107612584 1.3815542581681541 8.620166919015697e-06 0.9998377030384368 0.003301073135281269 0.16981739324202336 0.04312065382398992 0.16741669802910578 0.13947264476938068 2.927267229456483e-09 8.533537629127254 -1.3815456380012352 down GKEDALVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKEDALVTK 9 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 4855900.0 1822200.0 583000.0 2450700.0 False True 1764355.2584218513 815794.9403048356 1808788.1505759233 1.0 0.46237566749144 1.025183642547032 20.750709650605245 -10.98943942694882 12.992700556019374 1.1868113453362839 0.7437796550203498 0.21651037952546381 0.2297653936758739 0.0673495058860306 5.474221404795865e-05 0.012050800107566751 0.07415646193678756 1.0246146780720225e-11 10.98943942694882 -0.44303169031593403 GKEDALVTK(ub)NLVPGESVYGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKEDALVTKNLVPGESVYGEK 21 2 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 9874600.0 3236500.0 3217400.0 3420700.0 True False 4243082.842310582 2737376.4613269693 3066758.7776713814 1.0 0.6451385850944931 0.7227666514286979 22.016681415528577 -9.937844321820391 5.474433536170887 1.0000004842298202 0.6839526182606942 0.956711225551211 0.03169152537613192 1.8728620909512984e-07 3.633291946548208e-08 0.030685234593130682 0.010228395832678556 1.153866801393156e-10 9.937844321820391 -0.31604786596912604 GKEDALVTK(ub)NLVPGESVYGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKEDALVTKNLVPGESVYGEK 21 2 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 23552500.0 7091900.0 6161600.0 10299000.0 True False 10758930.787338605 5062014.339199468 8263398.135787947 1.0 0.47049418192712794 0.7680501249726909 23.359031375521482 -10.166675055881127 5.541069166975816 1.0000091855145299 0.6192721534498704 0.6858195794118888 0.12147670506586708 1.3784870204606669e-05 2.0728424840495127e-06 0.11762214987573892 0.039206437972665514 6.812789087478191e-11 10.166675055881127 -0.3807370320646595 GKEDALVTK(ub)NLVPGESVYGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKEDALVTKNLVPGESVYGEK 21 2 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 13201000.0 3236500.0 4839400.0 5125100.0 True False 4433121.513123815 4625579.30624426 3914656.934747761 1.0 1.043413606541281 0.8830475147497783 22.07989147705147 -6.834609781982242 1.307197763184126 1.0231338474398322 0.8783116788724125 0.9147812747196647 0.019770406903407832 0.17519054154866875 0.5838196661262757 0.011868896446480754 0.027316567744970186 1.4634915459482503e-07 6.834609781982242 -0.1448221685674197 GKEDALVTK(ub)NLVPGESVYGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKEDALVTKNLVPGESVYGEK 21 2 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 22642500.0 7091900.0 6985600.0 8565000.0 True False 9180604.352248559 6596845.219164079 7006257.884321403 1.0 0.718563284730634 0.7631586783941294 23.13015769761393 -10.177370570997235 5.281378289289946 1.0000117196759337 0.7408609815623272 0.9782712382796166 0.01820599322601994 2.512449314271643e-06 3.9136003862993434e-07 0.017628674024367817 0.005875959047080037 6.647057398558656e-11 10.177370570997235 -0.25915073811360656 GKENK(ub)GSVEIMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKENKGSVEIMR 12 2 A0A1X7SBW3;Q5TA31 A0A1X7SBW3 RNF187 E3 ubiquitin-protein ligase RNF187 1 5723360.0 587990.0 875570.0 4259800.0 True False 569324.579299454 1225189.6670372318 3144030.5887392624 1.0 2.152005572190139 5.52238688273032 19.11889186060177 -6.952013389643364 0.5362850041782203 0.9491300948659832 6.879919287095184 0.9993499599622409 0.048923292658918774 0.08268720767624674 0.032693379291047535 0.05408888754676582 0.2789557878548158 1.1168288145315299e-07 6.952013389643364 5.930789192229201 GKENK(ub)GSVEIMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKENKGSVEIMR 12 2 A0A1X7SBW3;Q5TA31 A0A1X7SBW3 RNF187 E3 ubiquitin-protein ligase RNF187 1 3727990.0 587990.0 1272500.0 1867500.0 True False 488939.7373736331 1265644.789928527 2257985.615655598 1.0 2.588549657933324 4.618126617780124 18.899297136036047 -6.967786273854048 0.3064843342882194 0.6740576365449805 6.596806631059538 0.9999596039295895 0.009411317510285998 0.07702773810487061 0.01158779090730988 0.03263529535021289 0.18081247201970002 1.0769950969031897e-07 6.967786273854048 5.922748994514557 GKENK(ub)GSVEIMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GKENKGSVEIMR 12 2 A0A1X7SBW3;Q5TA31 A0A1X7SBW3 RNF187 E3 ubiquitin-protein ligase RNF187 1 27011240.0 2296940.0 12508600.0 12205700.0 True False 2973434.1094563957 11812485.414056884 9984387.841058014 1.0 3.972674348656223 3.3578641643023874 21.503698675637335 -10.629963951423827 9.065506990987442 0.9988219148220094 3.6652692564793052 0.9616234240174146 0.25099520672222586 0.005975375033910893 0.00024390309425333654 0.24298529888552456 0.08100835463442237 2.344423405907291e-11 10.629963951423827 2.666447341657296 GKGGEIQPVSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKGGEIQPVSVK 12 1 P61604;B8ZZL8 P61604 HSPE1 10 kDa heat shock protein, mitochondrial 0 18544400.0 5049500.0 1642900.0 11852000.0 False True 4889206.3864565585 2298918.53761032 8747605.647621436 1.0 0.47020280100641365 1.7891667800837598 22.221168875965546 -6.797706151835995 1.4654204667017063 0.7068268864507007 1.8063237876467515 0.8253090848986697 0.22650281247360451 0.22406006373644521 0.9501731621661715 0.12161330694389635 0.2832119781932386 1.5932863965782066e-07 6.797706151835995 1.099496901196051 GKLDVQFSGLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKLDVQFSGLTK 12 1 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 17701500.0 4782200.0 6759900.0 6159400.0 False True 6269510.51089067 5751349.26988382 5522084.373136806 1.0 0.9173522015623452 0.8807839724559802 22.579921379005818 -13.999999992628608 0.11056470765937736 1.3983975650934286 0.8142430120041861 0.9997401821934756 0.0008037768397200768 12.009338282226132 0.10099308394827632 1.0669404563875986 0.05909404234910427 1.0000000169732584e-14 13.999999992628608 -0.5841545530892425 GKLDVQFSGLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKLDVQFSGLTK 12 1 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 12036500.0 3391700.0 2195800.0 6449000.0 False True 3284032.3400227134 3072594.39094573 4759813.434147034 1.0 0.9356163620862755 1.4493808042444898 21.647036903675172 -6.87548766766539 1.1047098610546522 0.9620518933988566 1.4827742001370023 0.9698572804175911 0.039676961978820084 0.13169951700874793 0.2971102716036204 0.027771203022078122 0.06644949295196231 1.332024866287019e-07 6.87548766766539 0.5207223067381458 GKLDVQFSGLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKLDVQFSGLTK 12 1 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 29520500.0 7228800.0 15362000.0 6929700.0 False True 10966618.096069233 12620531.076146169 5560041.757604588 1.0 1.1508134016875948 0.5069969345971366 23.386615357841606 -6.844980904630163 1.2590513888425225 1.0802556757810804 0.4836444524136575 0.9326815665672108 0.07133371038245769 0.163064215943577 0.49995433189282845 0.044385242449690214 0.10243452657355939 1.428956786522026e-07 6.844980904630163 -0.5966112233674229 GKLDVQFSGLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKLDVQFSGLTK 12 1 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 16463000.0 4782200.0 4926600.0 6754200.0 False True 6550308.574095688 4708926.521912421 5158997.067115437 1.0 0.7188862125571723 0.7875960359360124 22.64313144052871 -10.497267713614166 6.137205572574396 1.0002027222386185 0.7532411242465926 0.9450451606231686 0.02805066793248545 7.787000219939109e-05 6.378737579762224e-06 0.027182032050837586 0.009053314146042546 3.1822352809517205e-11 10.497267713614166 -0.24696159799202588 GKLDVQFSGLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GKLDVQFSGLTK 12 1 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 7547200.0 3391700.0 2185800.0 1969700.0 False True 2820348.82778644 2174024.661552671 2381555.1631361917 1.0 0.7708353804089408 0.8444186547680923 21.42744217910945 -10.320650623383031 7.853000132109706 1.0000008896380177 0.8076270175885166 0.901118868839669 0.03004024596385699 4.6789654409376e-07 4.051106906136261e-08 0.029086477436738898 0.009695447694499388 4.779135859042054e-11 10.320650623383031 -0.19237387204950107 GKLDVQFSGLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKLDVQFSGLTK 12 1 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 24971700.0 7228800.0 10530000.0 7212900.0 False True 9357824.100951008 9943996.243386073 5900226.210603844 1.0 1.0626397906299065 0.6305126220532636 23.157741679934055 -6.870095163060188 1.1335178342572245 1.0354513829243597 0.6051512125148922 0.9647818842424808 0.0357811433221657 0.13676753818442955 0.3283674629989507 0.02449554520286392 0.058007046468492494 1.348667328818992e-07 6.870095163060188 -0.43030017040946744 GKLEEQRPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKLEEQRPER 10 2 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;E9PJF7 P13693 TPT1 Translationally-controlled tumor protein 0 18426610.0 719210.0 9961400.0 7746000.0 False True 942891.2748395483 8475197.949233076 6944518.22487868 1.0 8.988520920055496 7.365131495209167 19.84673189720029 -10.001248227350128 7.5933157315691835 0.9999998128910961 8.176826207632333 0.9630437540911158 0.6627459574506299 2.0995731914837634e-06 2.8207815258612585e-07 0.6417010522345136 0.21390033799771466 9.971299767248873e-11 10.001248227350128 7.176826394741237 GKLEEQRPER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKLEEQRPER 10 2 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;E9PJF7 P13693 TPT1 Translationally-controlled tumor protein 0 10737900.0 4350900.0 1523100.0 4863900.0 False True 4212783.06106225 2131281.772861569 3589898.676127732 1.0 0.5059082658588567 0.8521442058833529 22.006342194982718 -10.131220244147578 5.907849897944243 1.0000023650980137 0.6790262358710972 0.5339874934915143 0.1413502306121828 4.403267986609013e-06 6.476077635588535e-07 0.13686277960985763 0.04562059076195854 7.392302934664969e-11 10.131220244147578 -0.32097612922691643 GKLEEQRPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKLEEQRPER 10 2 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;E9PJF7 P13693 TPT1 Translationally-controlled tumor protein 0 19238710.0 719210.0 10209000.0 8310500.0 False True 985121.3729194447 9757932.623351593 6347731.060120049 1.0 9.90531003751709 6.443603026608089 19.90994195872318 -10.011050737721789 8.288864136015835 0.9999999544464939 8.174456532062589 0.8513479345034132 1.4132359692903689 1.1976174038814347e-06 1.377569247541732e-07 1.368359843329662 0.45611994777690784 9.748757383576365e-11 10.011050737721789 7.174456577616095 GKLGLVGVNLTLDGVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKLGLVGVNLTLDGVK 16 1 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 0 19094600.0 2543300.0 5721300.0 10830000.0 False True 3858372.040135686 4700289.314279071 8689445.753042366 1.0 1.2182053118220755 2.2521015761706558 21.879560830020825 -6.941012907567843 0.6500823317183383 0.9885671725327638 2.5394096081551725 0.9982934629957618 0.022560732478238688 0.08730776142655462 0.052530114731671275 0.022133390325737072 0.08859587786244931 1.1454788964210135e-07 6.941012907567843 1.5508424356224086 up GKLGLVGVNLTLDGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKLGLVGVNLTLDGVK 16 1 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 0 17431600.0 2543300.0 5051500.0 9836800.0 False True 3292351.9859380075 4770379.584374622 8046603.334091406 1.0 1.4489275766228615 2.4440288791901117 21.650687152113274 -6.957985379025411 0.4629601414746575 0.9718362638502884 2.9614339130056093 0.9996880054247275 0.010658331637587958 0.08042889110846274 0.023851633359418575 0.013583890195628206 0.08218007416746313 1.1015763946300665e-07 6.957985379025411 1.989597649155321 up GKLPGPTLWASYSLEYGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKLPGPTLWASYSLEYGK 18 1 P07741-2;P07741;H3BQB1;H3BQF1 P07741-2 APRT Adenine phosphoribosyltransferase 0 14089000.0 8707100.0 0.0 5381900.0 False True 8430697.876525585 0.0 3972218.9364608256 1.0 0.0 0.47116134330006804 23.00722062888181 -10.691571254680918 7.4860929300979935 1.0037532319950906 0.2355806716500364 0.7782528817693465 0.19235081293491005 0.01205777615256282 0.0004967825643792984 0.18637614263852306 0.062080957927197096 2.0343643903709903e-11 10.691571254680918 -0.7681725603450542 GKQPPCPK(ub)CGHETQETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKQPPCPKCGHETQETK 17 2 Q9Y3S2;D6RBR7 Q9Y3S2 ZNF330 Zinc finger protein 330 1 4821800.0 1551000.0 1281900.0 1988900.0 True False 2352980.393288428 1053134.929469585 1595793.0432341618 1.0 0.44757488522790756 0.6782007397027 21.166057868371976 -10.288013200464986 5.684288575301411 1.0000392152046043 0.5628878124653017 0.8272795674434092 0.0941526108261193 4.67955547020537e-05 5.861323663805264e-06 0.09117102861413433 0.03038762447762312 5.1521298434520186e-11 10.288013200464986 -0.43715140273930253 GKTPALK(ub)YQQLFEDIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GKTPALKYQQLFEDIR 16 2 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 33194400.0 10900000.0 9836400.0 12458000.0 True False 16536096.89674006 8081017.567856013 9995670.839464622 1.0 0.4886895389110299 0.6044758265437581 23.979115411887534 -9.844624010343047 6.52879952263905 1.0000000129801527 0.5465826827274125 0.9533725191380547 0.04726955398538597 8.902075372375953e-09 1.6191446082596622e-09 0.04576854986494392 0.015256182947312973 1.4301315565007853e-10 9.844624010343047 -0.4534173302527402 GKTPALK(ub)YQQLFEDIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKTPALKYQQLFEDIR 16 2 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 5170000.0 2448200.0 1703900.0 1017900.0 True False 3353365.7001173226 1628616.063956193 777492.984308549 1.0 0.4856661067115982 0.23185451687579056 21.677178393635828 -9.494802473249234 0.20426321777364057 1.4919528546605325 1.0534400950815106e-16 0.9994581861434542 0.007438118891557083 0.9161263362630099 0.08078694395296704 0.417363636839433 0.14004423532695318 3.200350368965505e-10 9.494802473249234 -1.4919528546605325 GKTPALK(ub)YQQLFEDIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GKTPALKYQQLFEDIR 16 2 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 33503000.0 10900000.0 10499000.0 12104000.0 True False 14110264.871121889 9914721.420637278 9901196.197527891 1.0 0.7026601917961708 0.7017016539350519 23.750241733979983 GKVKVGVNGFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKVKVGVNGFGR 12 2 P04406 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 30990380.0 26705000.0 931880.0 3353500.0 False True 35010513.61158785 792847.1364397894 3006511.989043458 1.0 0.0226459727279571 0.08587454678323703 25.061284890772455 -10.702193973870006 2.9273944181541367 1.1270431090231008 0.05426025803431399 0.9966588842911193 0.025812962914525155 21850442.230854023 20548262.97904424 20502417.818409033 0.009864862404333544 1.985208043331169e-11 10.702193973870006 -1.072782850988787 GKVKVGVNGFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKVKVGVNGFGR 12 2 P04406 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 33540980.0 26705000.0 6183800.0 652180.0 False True 36578560.1754894 5910579.26890798 498148.51606871973 1.0 0.1615858918599138 0.01361859279530963 25.124494952295347 -10.498122411078617 0.37270908053595675 1.6498874628684248 1.5656215768437218e-23 0.9990300162508934 0.013527007980217382 2.1454545242923033 0.19129092023923885 1.3659432181507156 0.04134407595565146 3.175978756992584e-11 10.498122411078617 -1.6498874628684248 GKVPVTYLELLS ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKVPVTYLELLS 12 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 0 6827400.0 1995400.0 2259500.0 2572500.0 False True 2615988.7234810903 1922391.4074620155 2306322.3771624584 1.0 0.7348622684060708 0.8816255041395746 21.31892489127142 -10.111272994572461 4.879802568835207 1.0000088295108758 0.8082438864595854 0.6947645183806079 0.05991584009504819 15775380.386924531 32687629.563826583 974.4866607779418 0.0205107861014941 7.739751293314679e-11 10.111272994572461 -0.19176494305129033 GKVPVTYLELLS ddPTM_RPMI8226_Bortezomib_2h_R1 1 GKVPVTYLELLS 12 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 0 5438800.0 1904500.0 1496500.0 2037800.0 False True 1844042.689970595 2094060.254144402 1504039.0473104082 1.0 1.1355812235441218 0.8156205143680223 20.814440624167332 -6.791548426457526 1.4899166025163195 1.075621903823427 0.8120594296819527 0.8063956361648037 0.05769733294462981 0.23303454587163674 1.021871635757925 0.030477365536179572 0.0712822540046518 1.6160380180610573e-07 6.791548426457526 -0.26356247414147427 GKVPVTYLELLS ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GKVPVTYLELLS 12 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 0 8567300.0 1995400.0 3171200.0 3400700.0 False True 2733153.3036574307 3031085.898243954 2597524.6996149733 1.0 1.1090069094140595 0.9503765105817654 21.38213495279431 -6.721776019766298 1.7528759460573442 1.0661925312236995 0.950598079874259 0.5208903239509448 0.045860843379912204 0.3518871440099425 2.113945180566588 0.020766071811647774 0.05202299766732955 1.8976843683713023e-07 6.721776019766298 -0.11559445134944046 GKYFVTFPYPYMNGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GKYFVTFPYPYMNGR 15 1 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 3747410.0 1289900.0 688110.0 1769400.0 False True 1691071.3914093694 585446.6702317721 1586319.4612832868 1.0 0.34619867215886746 0.9380558794512037 20.689506136143716 -10.627713463162449 9.44365666608506 1.0001091396015571 0.6421272758050471 0.3277247174110681 0.2416246930758125 0.0005553872632136821 2.1894054163902202e-05 0.23402213191263138 0.07798403435959171 2.356603600292322e-11 10.627713463162449 -0.35798186379651 GLAAALLLCQNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLAAALLLCQNK 12 0 O43290 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 0 16219800.0 5543400.0 4396000.0 6280400.0 False True 7267451.082361963 3740133.935473791 5630564.453850774 1.0 0.5146417764752571 0.7747646857253848 22.79301802485372 -10.167407957029948 5.175777908982374 1.0000174292873802 0.6447032311000701 0.7132620992979163 0.10619473301272923 2.1359024001342157e-05 3.4358922891010462e-06 0.1028276476489803 0.03427420270097734 6.801301743224723e-11 10.167407957029948 -0.35531419818731014 GLAAALLLCQNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLAAALLLCQNK 12 0 O43290 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 0 24360500.0 6363100.0 9553800.0 8443600.0 False True 9653287.904921714 7848849.745819901 6774718.759038644 1.0 0.8130752778872551 0.7018042790979604 23.202588976598822 GLAAALLLCQNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLAAALLLCQNK 12 0 O43290 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 0 22831200.0 5543400.0 8245500.0 9042300.0 False True 7592944.784752222 7881186.545777788 6906694.972014146 1.0 1.0379617881068224 0.9096200707114097 22.85622808637661 -6.827497036807682 1.339272768883131 1.020321451317324 0.9063449761290963 0.9007302245161335 0.01696099158340933 0.1839238836811785 0.6460989023646084 0.009946539940780678 0.02289093087160825 1.4876575243358198e-07 6.827497036807682 -0.11397647518822773 GLAAALLLCQNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLAAALLLCQNK 12 0 O43290 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 0 28138000.0 6363100.0 12268000.0 9506900.0 False True 8237158.385452815 11585275.01556129 7776741.749031543 1.0 1.4064650057016503 0.9441049188474525 22.97371529869127 -6.674577287691324 1.9214250981663483 1.258425185503365 0.9459445833492764 0.299317538155371 0.17247905391933477 0.45071631379578536 3.2123006991771548 0.07216052071798282 0.1916320018863039 2.1155471658218085e-07 6.674577287691324 -0.31248060215408857 GLAAEDSGGDSK(ub)DLSEVSETTESTDVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLAAEDSGGDSKDLSEVSETTESTDVK 27 1 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 10479100.0 3946800.0 4359700.0 2172600.0 True False 5174293.020865573 3709249.753977498 1947800.1930507915 1.0 0.7168611709889214 0.3764379375493808 22.302930325662157 -6.968672447938339 0.2881366530720616 1.0680163823002495 0.014792323412463698 0.9999700954123645 0.0013940528975220016 0.076735874903612 0.010564386093491442 0.006007638220791111 0.030938273876117146 1.0747997384130338e-07 6.968672447938339 -1.053224058887786 down GLAAEDSGGDSK(ub)DLSEVSETTESTDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLAAEDSGGDSKDLSEVSETTESTDVK 27 1 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 13674000.0 3328600.0 6345100.0 4000300.0 True False 3222935.4149835226 8878731.519259367 2952501.4235723955 1.0 2.75485865400277 0.9160907816663432 21.619943847570664 -6.656766793853306 1.9843281506283974 2.1325891122463814 0.9238021720291073 0.22191738523208104 0.7477637670778489 0.4921933190820613 3.7220893098371355 0.30481253666804936 0.8286847509956823 2.2041097015476324e-07 6.656766793853306 -1.2087869402172742 GLAAEDSGGDSK(ub)DLSEVSETTESTDVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLAAEDSGGDSKDLSEVSETTESTDVK 27 1 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 9114600.0 3946800.0 2770000.0 2397800.0 True False 5406038.618259569 2647612.240834943 1831489.024241124 1.0 0.4897508929907202 0.3387857826348191 22.366140387185048 -13.999999999999998 0.17070283650313836 3.577969318078079 0.20660880318531238 0.9995123546410888 0.0062474392714725125 12.098434905873619 0.13084891794049952 10.328501534932068 0.12229681329419718 1.0000000000000041e-14 13.999999999999998 -3.371360514892767 GLAAEDSGGDSK(ub)DLSEVSETTESTDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLAAEDSGGDSKDLSEVSETTESTDVK 27 1 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 10807200.0 3328600.0 5181800.0 2296800.0 True False 2767878.381982473 5153884.614893226 2777050.2607966657 1.0 1.8620343467554354 1.0033136856279152 21.40034912300494 -10.256509547957604 3.9844398482190857 0.9995317543691344 1.4326740157508107 0.25289410368430987 0.3505712420779006 47575347.97495944 40822664.966855004 172961.84468427862 0.12000986070171944 5.539753646647159e-11 10.256509547957604 0.4331422613816762 GLAAHYFFPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLAAHYFFPR 10 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 33493800.0 8773800.0 15324000.0 9396000.0 False True 11502536.765600074 13037718.932484152 8423792.052796282 1.0 1.13346466072382 0.7323421106541295 23.455448731951467 -6.8170060038400475 1.384729818247312 1.0721624545457267 0.7241317555883219 0.8773652439977344 0.05840658432189859 0.1974035487689101 0.7445509041202222 0.03315162011118006 0.07647864640166568 1.524031684900283e-07 6.8170060038400475 -0.3480306989574048 GLAAHYFFPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLAAHYFFPR 10 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 20382600.0 5813700.0 4880900.0 9688000.0 False True 5629147.275758486 6829868.82355724 7150422.166229869 1.0 1.213304340600498 1.2702496161403776 22.42448496335099 -13.677394544421691 0.18903526881968113 7.239823618946295e-14 1.31205799055641 0.9994796538161758 0.002653416350463511 10.860495493046402 0.13588396082216359 4.016964630248773 0.0394760509339099 2.101868083625159e-14 13.677394544421691 1.3120579905563376 GLAAHYFFPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLAAHYFFPR 10 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 83291000.0 31549000.0 34089000.0 17653000.0 False True 47862139.54084881 28005551.61142736 14163876.812415244 1.0 0.5851295382966638 0.29593070740865707 25.512381554108845 -8.134642815238664 0.2262761138481788 1.224066923077185 8.597142054122902e-25 0.9996860028022074 0.0051203107821117585 0.08888862766340272 0.04539469755123633 0.08826593648058402 0.10534738070770855 7.334274913524304e-09 8.134642815238664 -1.224066923077185 down GLAAHYFFPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLAAHYFFPR 10 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 46221800.0 8773800.0 18865000.0 18583000.0 False True 12017710.963029748 18031481.921787426 14194078.128898477 1.0 1.500409019426239 1.1810966474866902 23.51865879347436 -10.113109863233454 4.730491349234183 0.9999782794038293 1.3407528334550376 0.6029224907019808 0.13035872998232126 2.9873704228213664e-05 5.6004249665242515e-06 0.1262273369032186 0.04207309918586649 7.707084787071172e-11 10.113109863233454 0.34077455405120827 GLAAHYFFPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLAAHYFFPR 10 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 28007100.0 5813700.0 15945000.0 6248400.0 False True 4834349.140579071 15859101.120165285 7554911.550662621 1.0 3.2805038814936816 1.5627567084982352 22.204890238785268 -6.574001435332802 2.290911446243715 2.558522508504123 1.5666123695427812 0.0 0.9922181827428639 0.7174432619920839 7.073955416625932 0.36509171680713237 1.1107435213398593 2.666849850632395e-07 6.574001435332802 -0.9919101389613421 GLAAHYFFPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLAAHYFFPR 10 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 87398000.0 31549000.0 33318000.0 22531000.0 False True 40840802.4237637 31463824.011124175 18430589.18758269 1.0 0.770401709659274 0.4512788215164606 25.283507876201295 -6.966492912933586 0.33143189069127765 1.0382358975754535 0.1729753092605332 0.9999406934423891 0.0017327792911684607 0.07745794339811793 0.013093152346240668 0.00463305105026121 0.027802718710665128 1.0802072481794143e-07 6.966492912933586 -0.8652605883149204 down GLAAIK(ub)FEGAIYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLAAIKFEGAIYR 13 1 P22102;P22102-2 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 6000700.0 1210700.0 1686200.0 3103800.0 True False 1172266.991203675 2359508.4534168346 2290821.667995898 1.0 2.012773942388422 1.9541808181800797 20.16086975940669 -10.396422321683287 5.9029749905797155 0.9997309330006592 1.9834773802842518 0.997344958921106 0.02392054279099547 8.472609420639094e-05 8.663163343620612e-06 0.02316698947046774 0.007720321988480179 4.014002866727056e-11 10.396422321683287 0.9837464472835926 GLAAIK(ub)FEGAIYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLAAIKFEGAIYR 13 1 P22102;P22102-2 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 5825200.0 1210700.0 2102700.0 2511800.0 True False 1006750.6931040622 2091372.3377467284 3037005.7667489853 1.0 2.077348793571235 3.016641346811635 19.941275034840967 -6.972732157620999 0.18141908016559155 0.2873912450424564 4.832035114100042 0.9999965970364242 0.0015199087644638834 0.07542576210852482 0.0057305266965729865 0.035720773409862634 0.10495848288218594 1.0647995094267721e-07 6.972732157620999 4.544643869057586 GLAAITMDKEYQQK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLAAITMDKEYQQK 14 1 Q709C8-3;Q709C8;Q709C8-4;Q709C8-2;A0A3B3IU50 Q709C8-3 VPS13C Vacuolar protein sorting-associated protein 13C 1 5923900.0 1938000.0 1394200.0 2591700.0 True False 1876479.2508075656 1950911.3306569515 1912856.0206665918 1.0 1.039665815551839 1.0193856499310456 20.83959690701907 -9.948813288134359 8.701729027244774 0.9999999810258929 1.0295257327413998 0.7386414216400481 0.008279342945020135 6.003442366050946e-12 0.0 0.008016439335897475 0.0026721464452991576 1.1250885680365984e-10 9.948813288134359 0.029525751715506865 GLADASGPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLADASGPR 9 0 G3XAC1;Q9BXS9-7;Q9BXS9-2;Q9BXS9-3;Q9BXS9;F8W9I8;C9J6Y3;C9JKR6 G3XAC1 SLC26A6 Solute carrier family 26 member 6 0 5965000.0 1833400.0 2550400.0 1581200.0 False True 2403605.1546708555 2169890.2613813374 1417592.5919414123 1.0 0.9027648560183245 0.5897776467930459 21.196768490255213 -6.949857595200332 0.5604035202222738 1.0040848353518952 0.4734891092693445 0.9991900690389413 0.004981031610505384 0.08354295444275028 0.03619921444050786 0.005336783097134914 0.026020013692868146 1.122386423545711e-07 6.949857595200332 -0.5305957260825507 GLADASGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLADASGPR 9 0 G3XAC1;Q9BXS9-7;Q9BXS9-2;Q9BXS9-3;Q9BXS9;F8W9I8;C9J6Y3;C9JKR6 G3XAC1 SLC26A6 Solute carrier family 26 member 6 0 5789500.0 1833400.0 2212100.0 1744000.0 False True 2511257.525772039 2114362.1075635296 1332103.1188074567 1.0 0.841953517655864 0.5304526139340993 21.259978551778104 -6.960330188994509 0.4307570557265121 1.0122743985330673 0.34817128332275904 0.9997822443033045 0.0028786191199429933 0.07958341026603664 0.020697230389076084 0.004064876669286364 0.02585969466460919 1.0956448734698724e-07 6.960330188994509 -0.6641031152103083 GLAEAAGPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLAEAAGPR 9 0 Q8TBP5 Q8TBP5 FAM174A Membrane protein FAM174A 0 117098000.0 34902000.0 48578000.0 33618000.0 False True 45756859.99144879 41330351.75556092 30139531.84662682 1.0 0.9032602272814368 0.6586888141419539 25.447484716542064 -6.955221346394583 0.4982377142826549 1.004973716752116 0.5464583243480082 0.9995498770162381 0.0030472705925099126 0.08145441887779284 0.027791336423262633 0.003585617432653713 0.020173831605875308 1.1086096473813922e-07 6.955221346394583 -0.45851539240410777 GLAEAAGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLAEAAGPR 9 0 Q8TBP5 Q8TBP5 FAM174A Membrane protein FAM174A 0 64416000.0 20266000.0 23407000.0 20743000.0 False True 19622666.923047557 32753537.16589247 15309786.023338802 1.0 1.6691684822628372 0.7802092388041753 24.22601779624687 -6.705326706964138 1.8120512686572692 1.413343021586308 0.7825879549861362 0.4428183580286995 0.28219904119081396 0.3845369874169893 2.458301503849162 0.1240773207756315 0.31699174876090286 1.9709394984764679e-07 6.705326706964138 -0.6307550666001719 GLAEAAGPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLAEAAGPR 9 0 Q8TBP5 Q8TBP5 FAM174A Membrane protein FAM174A 0 241947000.0 84965000.0 85565000.0 71417000.0 False True 128898116.77353385 70295257.22760366 57301398.64681685 1.0 0.5453551920475933 0.44454798938212514 26.9416559448983 -13.999999999999986 0.21166873657991064 3.6475748392838705 0.38612429656506303 0.9994910139467709 0.00545095665218101 12.78624556101653 0.14581216508561565 14.090060745977976 0.05902259672787319 1.0000000000000327e-14 13.999999999999986 -3.2614505427188076 GLAEAAGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLAEAAGPR 9 0 Q8TBP5 Q8TBP5 FAM174A Membrane protein FAM174A 0 97486000.0 34902000.0 30152000.0 32432000.0 False True 47806212.591085255 28819784.940669745 24772229.558006566 1.0 0.6028460189302669 0.51818013214931 25.510694778064956 -13.999999999999998 0.21722816934751998 3.367888581179223 0.4716715559000057 0.9994952716007807 0.004718781646389356 12.925714585498278 0.14767241064992812 13.110298335546624 0.047727901833581665 1.0000000000000041e-14 13.999999999999998 -2.8962170252792174 GLAEAAGPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLAEAAGPR 9 0 Q8TBP5 Q8TBP5 FAM174A Membrane protein FAM174A 0 68099000.0 20266000.0 37062000.0 10771000.0 False True 16852076.936026204 36862339.64976902 13023166.30052286 1.0 2.1874063232505825 0.7727929530562528 24.006423071681148 -6.684099123796141 1.8875827285918123 1.7485097842652235 0.7780228954497725 0.34290020929747267 0.5028067258856217 0.429459916267721 2.961880538667284 0.21348295419734267 0.5600540425384958 2.0696689116272808e-07 6.684099123796141 -0.970486888815451 GLAEAAGPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLAEAAGPR 9 0 Q8TBP5 Q8TBP5 FAM174A Membrane protein FAM174A 0 227086000.0 84965000.0 62844000.0 79277000.0 False True 109988867.41053863 59346676.155684195 64849399.450712085 1.0 0.5395698451386897 0.5895996656521486 26.71278226699075 -10.73186359122049 10.572296959165282 1.0006369214731163 0.5645847556683462 0.9901953340282923 0.020424588696833522 0.0003070019725964072 7.786220719776196e-06 0.019800190587381358 0.0065920076563310386 1.8541138958325516e-11 10.73186359122049 -0.43605216580477013 GLAESLELPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLAESLELPK 10 0 A0A3B3ITU7;Q9HB96 A0A3B3ITU7 FANCE Fanconi anemia group E protein 0 7440100.0 1923300.0 1893200.0 3623600.0 False True 2634395.9852281907 1809552.1640248047 2767780.310384572 1.0 0.686894519340099 1.0506318434678406 21.329040787730612 -6.678956250853797 1.905841110020519 0.8017025457861331 1.0492268205825708 0.3191910462339459 0.13273313464684774 0.44087812054406406 3.0952521277750056 0.05590586025744907 0.14763215289216758 2.094323419265055e-07 6.678956250853797 0.24752427479643768 GLAFELVYSPAIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLAFELVYSPAIK 13 0 P78346;P78346-2;Q5VU10;Q5VU11 P78346 RPP30 Ribonuclease P protein subunit p30 0 44944000.0 12718000.0 14175000.0 18051000.0 False True 19294135.810343146 11645360.50021951 14483211.937965639 1.0 0.6035699455363375 0.7506535706150425 24.201659090829583 -10.050851291084745 5.70713341493895 1.000001236328606 0.6771117580756164 0.8653309774366497 0.06004663849386938 9.445527646064579e-07 1.5726768992944413e-07 0.05814013035786302 0.01937996924016987 8.895056457322446e-11 10.050851291084745 -0.3228894782529895 GLAFELVYSPAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLAFELVYSPAIK 13 0 P78346;P78346-2;Q5VU10;Q5VU11 P78346 RPP30 Ribonuclease P protein subunit p30 0 38172000.0 12718000.0 12915000.0 12539000.0 False True 16463701.709259484 12196268.896802587 10257030.661004817 1.0 0.74079748966438 0.6230087766493047 23.972785412922033 -13.999999999976792 0.10623636301710593 2.259923197585395 0.3947327891132102 0.9997621951817712 0.0024283870972767936 12.03607964479808 0.09826963924048006 3.2769824979683886 0.20299305342095958 1.0000000000534387e-14 13.999999999976792 -1.8651904084721846 GLAFIQDPDGYWIEILNPNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLAFIQDPDGYWIEILNPNK 20 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 1288880000.0 506990000.0 559410000.0 222480000.0 False True 769140895.933785 459578914.8097211 178506730.48355204 1.0 0.5975224009532918 0.2320858654471022 29.518672663197194 -7.693174556276285 0.3184819579902708 1.0873591500490336 1.6072932940744073e-14 0.9993678321197647 0.007885359179493826 0.12368294329924077 0.04521607927965693 0.0326692689394084 0.07688340039489477 2.026867895390061e-08 7.693174556276285 -1.0873591500490176 down GLAFIQDPDGYWIEILNPNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLAFIQDPDGYWIEILNPNK 20 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 1443350000.0 506990000.0 501810000.0 434550000.0 False True 656308549.2669814 473883832.37355876 355466358.8595291 1.0 0.7220442776539033 0.5416147012811927 29.289798985289643 -8.641987588289183 0.10437422607930887 1.567206969257845 1.1004359124954104e-08 0.9999711095834095 0.0010133908141290477 0.22329360272502477 0.02763380382271615 0.21410306410494567 0.18022478141335385 2.280407242874053e-09 8.641987588289183 -1.5672069582534858 GLAFTDVDVDSIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLAFTDVDVDSIK 13 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-7;P02751-11;P02751-4 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 8288300.0 3688200.0 1360900.0 3239200.0 False True 3571120.10981861 1904314.466999746 2390756.346082964 1.0 0.5332541075176754 0.6694695984908777 21.767945227170188 -10.60552279563638 9.747890266527223 1.0000569191432764 0.6013618530042825 0.9194808390133735 0.0556097413245056 6.879919994612688e-05 2.7841429462802246e-06 0.05385150037756925 0.01794796683639271 2.480145754172481e-11 10.60552279563638 -0.39869506613899397 GLAGAVSELLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLAGAVSELLR 11 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 14303800.0 2531100.0 5407100.0 6365600.0 False True 3318296.611207266 4600381.756710723 5706948.775146877 1.0 1.3863684581942806 1.7198428723556962 21.662011418966983 -6.972843462856718 0.1775840482387913 0.7338034724164725 2.3814040555578586 0.9999969102279889 0.0005169977892496905 0.07539042622734597 0.005585299086424156 0.01312042282877116 0.037702255856160716 1.064526647165838e-07 6.972843462856718 1.647600583141386 GLAGAVSELLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLAGAVSELLR 11 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 18231600.0 7838600.0 4297400.0 6095600.0 False True 7589767.933632707 6013374.2306449395 4498979.495919776 1.0 0.792300144514003 0.5927690458074941 22.855624343487225 -6.971614119751168 0.21618506615175423 1.0965647240473337 0.2828950435151693 0.9999923827941832 0.00045883627658989976 0.07578232487345236 0.007125473811907692 0.005691812165101611 0.02039035488026535 1.0675442366133262e-07 6.971614119751168 -0.8136696805321644 GLAGAVSELLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLAGAVSELLR 11 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 27356300.0 2531100.0 6897200.0 17928000.0 False True 3466916.070405589 6592458.898009663 13693775.63875003 1.0 1.901534033166953 3.9498434229900514 21.725221480489875 -6.957476440680603 0.46964893150372705 0.9457135364581074 4.989585082365099 0.999664853584278 0.022595051806255262 0.08061519326417745 0.02455769980362217 0.028302571522083618 0.16906251334987535 1.102868059882858e-07 6.957476440680603 4.043871545906991 GLAGAVSELLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLAGAVSELLR 11 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 13337900.0 7838600.0 2705700.0 2793600.0 False True 6518143.20885892 2691123.8570605996 3377728.8438530047 1.0 0.41286663560920955 0.518204147350165 22.6360296189215 -9.89581093830912 5.63360345265381 1.0000003216293243 0.46553539147885187 0.9716914351637873 0.04300385909451827 1.7373961192332254e-07 3.403187812692032e-08 0.041638332960021666 0.013879435840647325 1.271127345448065e-10 9.89581093830912 -0.5344649301504725 GLAGHLK(ub)SNSPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLAGHLKSNSPR 12 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 3897240.0 632540.0 1256000.0 2008700.0 True False 829266.0655260739 1068609.6958496536 1800858.9928109748 1.0 1.288621035242463 2.171629911889059 19.661475531320814 -6.951009221500114 0.547654688793009 0.9876150196046163 2.51395167397084 0.9992781038729863 0.013391372780164319 0.08308305800777956 0.03430504574720913 0.014578872080567594 0.07322118850803189 1.1194141143717412e-07 6.951009221500114 1.5263366543662238 up GLAGHLK(ub)SNSPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLAGHLKSNSPR 12 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 2236800.0 1151100.0 1085700.0 0.0 True False 1114558.9605802842 1519225.6718507041 0.0 1.0 1.3630733999569966 0.0 20.08804150704058 -6.86639459069959 1.369411815705425 1.19090678740653 2.6548351663284505e-22 0.9160958454254119 0.1669517290322066 0.159888510584521 0.6028641282759588 0.09849102021864238 0.20393324591448184 1.3602082646534789e-07 6.86639459069959 -1.19090678740653 down GLAGHLK(ub)SNSPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLAGHLKSNSPR 12 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 1523500.0 632540.0 890960.0 0.0 True False 866407.1317507618 851594.4411892764 0.0 1.0 0.9829033141364463 0.0 19.724685592843706 -7.036987746526514 1.0684815916879664 1.0168165890271554 1.3672257968307346e-18 0.9870196583254078 0.053254556014051484 0.08630716424375869 0.1905128210224327 0.041906135750123585 0.07545131274604899 9.183585072960341e-08 7.036987746526514 -1.0168165890271554 down GLAGHLK(ub)SNSPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLAGHLKSNSPR 12 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 4361200.0 1151100.0 1483300.0 1726800.0 True False 957190.6523763821 1475309.1684880024 2087865.8961788942 1.0 1.5412908231242193 2.181243507754099 19.868446782474855 -6.96891068174395 0.2829954964818341 0.8640044293491929 2.878110924309302 0.999972595857834 0.0025274068089900094 0.07665777272515728 0.010289443393403892 0.011620414662067423 0.058520812542893166 1.0742103148170936e-07 6.96891068174395 2.0141064949601093 GLAITFVSDENDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLAITFVSDENDAK 14 0 O00148;Q13838-2;Q13838;A0A0G2JJZ9;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 79164000.0 27374000.0 22650000.0 29140000.0 False True 35887579.09019307 19270708.289008494 26124872.330617722 1.0 0.5369743175090504 0.7279641868558588 25.09698126910491 -10.198920420556524 5.426520261841876 1.000016527954517 0.6324692521824049 0.8315784052079231 0.07797128765692636 1.5591809469690903e-05 2.3017559775732473e-06 0.07549876548986766 0.025165124881443263 6.325277441551472e-11 10.198920420556524 -0.3675472757721121 GLAITFVSDENDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLAITFVSDENDAK 14 0 O00148;Q13838-2;Q13838;A0A0G2JJZ9;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 75690000.0 21232000.0 13630000.0 40828000.0 False True 20558001.78180923 19072530.079511013 30133921.986254442 1.0 0.927742408135569 1.4658001446871396 24.293196706974186 -6.873029366550049 1.117894733640229 0.9582766510653458 1.499187365760192 0.9676166956984191 0.04290874216328264 0.1339859980252706 0.31110013337732983 0.029729501775496072 0.07078312287185372 1.3395861029169496e-07 6.873029366550049 0.5409107146948462 GLAITFVSDENDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLAITFVSDENDAK 14 0 O00148;Q13838-2;Q13838;A0A0G2JJZ9;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 297987000.0 65442000.0 137310000.0 95235000.0 False True 99280298.45105165 112805957.69207327 76411760.5070167 1.0 1.1362370928779006 0.7696568372494381 26.565004116637954 -6.806051737007189 1.4308877191885248 1.0746016153072115 0.7637958979745482 0.8493199934250175 0.05872726143104206 0.2122288933696278 0.8570886562140375 0.03227769858266551 0.07481340053956836 1.5629614377333256e-07 6.806051737007189 -0.3108057173326634 GLAITFVSDENDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLAITFVSDENDAK 14 0 O00148;Q13838-2;Q13838;A0A0G2JJZ9;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 87618000.0 27374000.0 23771000.0 36473000.0 False True 37494907.554534614 22720718.61981493 27858828.58501393 1.0 0.6059681194511198 0.7430029943264842 25.1601913306278 -10.27889235755952 5.072382751292669 1.000071586929247 0.6744855584498135 0.8826766165993237 0.055944253402163475 4.530024730348543e-05 6.440070719547332e-06 0.05417966420287317 0.018055930145163004 5.261476590211652e-11 10.27889235755952 -0.3255860284794334 GLAITFVSDENDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLAITFVSDENDAK 14 0 O00148;Q13838-2;Q13838;A0A0G2JJZ9;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 52302000.0 21232000.0 12312000.0 18758000.0 False True 17655348.737082228 12245672.812259352 22680211.07280736 1.0 0.693595634649758 1.2846085008318875 24.073601982408462 -6.765801655276452 1.5903629805244872 0.823308897347819 1.2874281342460232 0.7142495326908269 0.12900697915991888 0.27330250890924146 1.3634975788431034 0.06396202548698554 0.152860059328656 1.7147402601911222e-07 6.765801655276452 0.4641192368982042 GLAITFVSDENDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLAITFVSDENDAK 14 0 O00148;Q13838-2;Q13838;A0A0G2JJZ9;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 226719000.0 65442000.0 98610000.0 62667000.0 False True 84715959.0546751 93122266.81484339 51262249.017719746 1.0 1.099229328853409 0.6051073444690089 26.336130438730404 -6.854466145328796 1.2133279369770988 1.0532293079649206 0.5835829388632348 0.9465592730288612 0.04933745769247254 0.1526103839727343 0.4300952180827055 0.03177822778263428 0.07377913517295116 1.3980858964301333e-07 6.854466145328796 -0.4696463691016859 GLAITFVSDENDAK(ub)ILNDVQDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLAITFVSDENDAKILNDVQDR 22 1 O00148;Q13838-2;Q13838;A0A0G2JJZ9;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 1 24547300.0 7385100.0 5251200.0 11911000.0 True False 9560157.532084627 4958966.103824218 9743320.21718066 1.0 0.5187117562845115 1.0191589609775074 23.188602960426095 -10.959477946391116 12.308550659579984 1.0732766730533003 0.7689353586310098 0.2213309305592076 0.20430671578333448 0.1021730912447918 0.00033637252591781433 0.04919802405368968 0.0659397089789322 1.0977970353332635e-11 10.959477946391116 -0.3043413144222905 GLAK(ub)RPGALLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLAKRPGALLLR 12 2 A0A0G2JKZ1;A2AB90;A0A0G2JH37;A0A0A0MSV9;O15533;O15533-3;Q6P1N7;O15533-2;A0A0A0MT98;O15533-4;A0A140T9B2;A0A0G2JJI5 A0A0G2JKZ1 TAPBP Tapasin 1 7388330.0 1104000.0 718030.0 5566300.0 True False 1068954.1242990466 1004743.1234769848 4108319.0445794133 1.0 0.9399310041820856 3.8433071646300934 20.02776850838216 -6.9021764349584265 0.9474008357997457 0.8863906276527543 4.161907913749648 0.9876184948863496 0.1507436057206356 0.10982110292327193 0.1685200783467908 0.11882853472087561 0.31269006421392 1.252632181585149e-07 6.9021764349584265 3.2755172860968935 up GLAK(ub)RPGALLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLAKRPGALLLR 12 2 A0A0G2JKZ1;A2AB90;A0A0G2JH37;A0A0A0MSV9;O15533;O15533-3;Q6P1N7;O15533-2;A0A0A0MT98;O15533-4;A0A140T9B2;A0A0G2JJI5 A0A0G2JKZ1 TAPBP Tapasin 1 7334400.0 1104000.0 1306700.0 4923700.0 True False 918024.9154925939 1299660.5477403568 5953222.905383387 1.0 1.415713806681363 6.484816266875508 19.808173783816436 -6.9231629474354275 0.8009091373420795 0.9003853531545342 7.364866390495415 0.9950155820986594 0.1760326007754208 0.0963462578483296 0.09622826130142094 0.15426857354899923 0.47706406547165453 1.1935402037580905e-07 6.9231629474354275 6.464481037340881 up GLALALFGGEPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLALALFGGEPK 12 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 107575000.0 28975000.0 50706000.0 27894000.0 False True 37986505.594299115 43140862.450439975 25007796.45814176 1.0 1.1356891552803006 0.6583336915805923 25.178983667774155 -6.830779427520183 1.324676937217772 1.0724617502768115 0.6453057766147127 0.9073756632267528 0.06112290325668906 0.1798544243238319 0.6170020244855264 0.0362281213904977 0.08335856718098862 1.4764562156590366e-07 6.830779427520183 -0.4271559736620988 GLALALFGGEPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLALALFGGEPK 12 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 111218000.0 44231000.0 35430000.0 31557000.0 False True 42826911.115825295 49577383.76500914 23291275.0102927 1.0 1.1576222163425984 0.543846717016352 25.352014291041648 -6.838576659656302 1.2891054676347784 1.0838707865332842 0.5242357078884649 0.9219593188487913 0.0727070180543146 0.17046903725689191 0.5509156252149042 0.04423748160040295 0.10187248916775285 1.4501847717927462e-07 6.838576659656302 -0.5596350786448193 GLALALFGGEPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLALALFGGEPK 12 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 148283000.0 35747000.0 65518000.0 47018000.0 False True 54230812.45575845 53825801.0055296 37724871.69127851 1.0 0.9925317097072949 0.6956353774351896 25.692609448378295 -6.912303747432067 0.8798849258033963 1.0085363767523603 0.6553119313280894 0.991762599187257 0.012865370218619722 0.10291468658464398 0.13064433024054617 0.01065451609886813 0.029903211598293795 1.2237599968689984e-07 6.912303747432067 -0.3532244454242709 GLALALFGGEPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLALALFGGEPK 12 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 155944000.0 28975000.0 54944000.0 72025000.0 False True 39687840.51993279 52516392.4044891 55014178.40143752 1.0 1.3232363292256555 1.3861721293152052 25.242193729297046 -12.517631193985109 0.2539303245796703 2.36266288109431e-16 1.4120641799837341 0.9994412979704765 0.003998686583447341 6.757784641487427 0.151663846292685 3.4909383362451036 0.028407210816778515 3.036468680788756e-13 12.517631193985109 1.412064179983734 GLALALFGGEPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLALALFGGEPK 12 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 85492000.0 44231000.0 19172000.0 22089000.0 False True 36780036.26553707 19068716.630655967 26707707.772003494 1.0 0.5184529045318906 0.7261468580178819 25.132419566475924 -10.26994520448635 5.6342578867511435 1.0000290957885554 0.6222998812748795 0.8151386171057353 0.08479070145036205 3.099201515231721e-05 4.015870778120551e-06 0.08210455624801694 0.02736608121920447 5.37099558662547e-11 10.26994520448635 -0.3777292145136759 GLALALFGGEPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLALALFGGEPK 12 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 129699000.0 35747000.0 54138000.0 39814000.0 False True 46275196.17871507 51125172.708873264 32568260.52613805 1.0 1.1048072602745445 0.7037951908482298 25.463735770470745 -6.837260070855884 1.2949440531010785 1.0557919923306818 0.6912959810270138 0.9196566932302059 0.04813372742977628 0.17202495841116214 0.5615085477276422 0.02915804638052172 0.0671374804776485 1.454587761256324e-07 6.837260070855884 -0.36449601130366793 GLALHDILTEIHLFVHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLALHDILTEIHLFVHR 17 0 P40937;P40937-2 P40937 RFC5 Replication factor C subunit 5 0 363790000.0 107970000.0 127560000.0 128260000.0 False True 163798383.66431415 104795921.36917089 102909354.78164501 1.0 0.6397860529804618 0.6282684387933024 27.28734587986913 GLALHDILTEIHLFVHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLALHDILTEIHLFVHR 17 0 P40937;P40937-2 P40937 RFC5 Replication factor C subunit 5 0 247827000.0 107970000.0 113830000.0 26027000.0 False True 139769293.4068835 107495260.43538812 21290353.059571907 1.0 0.7690906766084723 0.1523249673845985 27.058472201961578 -7.13887681995907 0.59214569152032 1.0030636715233279 6.009984138080592e-25 0.9986031196149316 0.013373214849521057 0.08043553510373405 0.046245455606760084 0.013503094692193107 0.04851226610315547 7.263119339114385e-08 7.13887681995907 -1.0030636715233279 down GLALLNGEYLLAAQLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLALLNGEYLLAAQLGK 17 0 U3KQC1;A0A0A0MQU0;Q9BV38;K7EIR0;K7EML4;A0A087X237;K7EKX5 U3KQC1 WDR18 WD repeat-containing protein 18 0 62405000.0 14876000.0 24901000.0 22628000.0 False True 22567979.58127572 20457221.99759898 18155565.881795283 1.0 0.90647113198259 0.8044834415243204 24.427773929947872 -6.9700161843800705 0.2578075213293953 1.0294105676134955 0.6785268407672157 0.9999825008968254 0.0003339537805758033 0.07629752049557988 0.009011750188181495 0.0021595493377810047 0.009654681599229314 1.0714793748371866e-07 6.9700161843800705 -0.3508837268462798 GLALLNGEYLLAAQLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLALLNGEYLLAAQLGK 17 0 U3KQC1;A0A0A0MQU0;Q9BV38;K7EIR0;K7EML4;A0A087X237;K7EKX5 U3KQC1 WDR18 WD repeat-containing protein 18 0 36715400.0 14876000.0 9536400.0 12303000.0 False True 19257275.249799028 9005690.956830671 10063980.23944031 1.0 0.4676513598113864 0.5226066569072558 24.19890025204032 -10.396703627481184 5.167728703116204 1.0003850422951555 0.4951290083592968 0.9911919988311901 0.022435406091407286 9.9601439277079e-05 1.1627791714660294e-05 0.02173909395571768 0.007240996179772869 4.011403716360841e-11 10.396703627481184 -0.5052560339358587 GLALVLSNVHFTGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLALVLSNVHFTGEK 15 0 P42575;P42575-2 P42575 CASP2 Caspase-2;Caspase-2 subunit p18;Caspase-2 subunit p13;Caspase-2 subunit p12 0 6144000.0 1839900.0 1929600.0 2374500.0 False True 2412126.7176169474 1641711.201521889 2128809.5178123466 1.0 0.6806073617657252 0.8825446450489537 21.201874268467446 -10.691788175450295 5.703951398767231 1.0038130726631733 0.7815760034073408 0.609365033383258 0.0824405506812949 0.004057193975508973 0.0002192292686063776 0.08101375113625754 0.026607573320068623 2.033348522759099e-11 10.691788175450295 -0.22223706925583253 GLALVLSNVHFTGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLALVLSNVHFTGEK 15 0 P42575;P42575-2 P42575 CASP2 Caspase-2;Caspase-2 subunit p18;Caspase-2 subunit p13;Caspase-2 subunit p12 0 6055400.0 1839900.0 1857700.0 2357800.0 False True 2520160.751427937 1775620.6714076046 1800936.2004152662 1.0 0.7045664330743696 0.7146116371326099 21.265084329990337 -9.970206704161823 5.164590687018405 1.0000013949291011 0.7095890351012185 0.9991034714976658 0.004100937392055471 6.586773731324836e-08 1.31407624612326e-08 0.003970734603519462 0.001323571850800676 1.0710094327696548e-10 9.970206704161823 -0.2904123598278826 GLALVLSNVHFTGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLALVLSNVHFTGEK 15 0 P42575;P42575-2 P42575 CASP2 Caspase-2;Caspase-2 subunit p18;Caspase-2 subunit p13;Caspase-2 subunit p12 0 8298200.0 1984500.0 3165500.0 3148200.0 False True 2568974.370343249 2989337.1423018635 2575259.9032598576 1.0 1.1636305822321025 1.0024467090793783 21.292761066428167 -6.642646118690574 2.034952166522958 1.1067849151673432 1.0031186669601921 0.1649843543288263 0.06996540659947555 0.5265932016265349 4.170891944358702 0.027967940085357634 0.07747544600663268 2.2769520308211553e-07 6.642646118690574 -0.10366624820715109 GLATVIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLATVIR 7 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 6226230.0 982730.0 3088900.0 2154600.0 False True 1288368.5467708567 2628048.1604378936 1931662.6603825972 1.0 2.039826388982241 1.499309079862343 20.29711391475114 -10.455526560295665 5.598335083733435 0.9993111858442483 1.7695677344222926 0.7299337932601073 0.22066526741433132 0.0018986755763595634 0.00018465798516638352 0.21383245856991429 0.07121940881517515 3.50326862587059e-11 10.455526560295665 0.7702565485780444 GLATVIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLATVIR 7 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 3831490.0 1529800.0 540590.0 1761100.0 False True 1481237.3363701848 756450.4061396079 1299815.0781324762 1.0 0.5106881845101958 0.8775197912022059 20.498371389269902 -10.333717890876075 6.0098031477826765 1.0000302935031757 0.6941039878562019 0.48110068078273616 0.14975837632012645 6.0791918291747684e-05 6.739667979037325e-06 0.1450172597210179 0.04833430812024258 4.637480635063933e-11 10.333717890876075 -0.3059263056469739 GLATVIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLATVIR 7 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 4513330.0 982730.0 1715500.0 1815100.0 False True 1346071.8382796743 1639703.5376001212 1386410.7631579202 1.0 1.2181396943091227 1.0299678841285325 20.36032397627403 -10.50013605925291 3.488828743728252 0.9977638659095855 1.1240537892433875 0.36688624149125204 0.07682081991903539 55592428.93207701 2572.7221874634115 999023.4378974459 0.026297798576003263 3.1612871116726045e-11 10.50013605925291 0.12628992333380196 GLAVFISDIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLAVFISDIR 10 0 O95782;O95782-2;M0R2D9;O94973;O94973-2;O94973-3;E9PR62 O95782;O94973 AP2A1;AP2A2 AP-2 complex subunit alpha-1;AP-2 complex subunit alpha-2 0 6882800.0 1796100.0 3080700.0 2006000.0 False True 2354704.4934571395 2621071.568474545 1798438.3629107438 1.0 1.1131212327311313 0.7637639321230943 21.167114587729554 -6.819539279939112 1.3739411540018005 1.060999527670419 0.7562166974388339 0.8833060790152729 0.04971944751986992 0.19407989454996144 0.7200286999038391 0.02843852767101963 0.06555201963510228 1.5151677575438874e-07 6.819539279939112 -0.30478283023158503 GLAVFISDIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLAVFISDIR 10 0 O95782;O95782-2;M0R2D9;O94973;O94973-2;O94973-3;E9PR62 O95782;O94973 AP2A1;AP2A2 AP-2 complex subunit alpha-1;AP-2 complex subunit alpha-2 0 5173700.0 0.0 2237000.0 2936700.0 False True 0.0 3130245.7658008924 2167490.170888443 0.0 GLAVFISDIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLAVFISDIR 10 0 O95782;O95782-2;M0R2D9;O94973;O94973-2;O94973-3;E9PR62 O95782;O94973 AP2A1;AP2A2 AP-2 complex subunit alpha-1;AP-2 complex subunit alpha-2 0 32222900.0 9090100.0 13313000.0 9819800.0 False True 13790346.275326332 10937191.13505623 7878912.225828771 1.0 0.7931048950253726 0.5713353434732606 23.717155347562628 -6.97024160919881 0.25234760441261445 1.0683776247224772 0.28954778864053066 0.999984205598939 0.000695609988709027 0.07622435898906073 0.008749140314638698 0.004868637470300683 0.021173940178444865 1.0709233572536921e-07 6.97024160919881 -0.7788298360819466 GLAVFISDIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLAVFISDIR 10 0 O95782;O95782-2;M0R2D9;O94973;O94973-2;O94973-3;E9PR62 O95782;O94973 AP2A1;AP2A2 AP-2 complex subunit alpha-1;AP-2 complex subunit alpha-2 0 10313200.0 1796100.0 3580200.0 4936900.0 False True 2460166.7077774378 3422014.9258618243 3770905.8986470946 1.0 1.390968715674288 1.5327847038682203 21.230324649252445 -12.017663241263971 0.1692774520496354 1.876714611590669e-19 1.673522200169066 0.9995073863876293 0.005000436852739409 5.3924639093907345 0.11160174697248801 2.0111811275629647 0.11480079611525594 9.601448542796255e-13 12.017663241263971 1.673522200169066 GLAVFISDIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLAVFISDIR 10 0 O95782;O95782-2;M0R2D9;O94973;O94973-2;O94973-3;E9PR62 O95782;O94973 AP2A1;AP2A2 AP-2 complex subunit alpha-1;AP-2 complex subunit alpha-2 0 4016800.0 0.0 1601200.0 2415600.0 False True 0.0 1592574.0177866837 2920690.791527531 0.0 GLAVFISDIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLAVFISDIR 10 0 O95782;O95782-2;M0R2D9;O94973;O94973-2;O94973-3;E9PR62 O95782;O94973 AP2A1;AP2A2 AP-2 complex subunit alpha-1;AP-2 complex subunit alpha-2 0 28291500.0 9090100.0 10919000.0 8282400.0 False True 11767313.642659198 10311348.051427584 6775088.184600537 1.0 0.876270350613125 0.5757548740809708 23.488281669655077 -6.956078111433407 0.48757846611393885 1.0067231974492483 0.4326111092769236 0.9995959407341759 0.003580813663945455 0.0811330772641043 0.026543407484187098 0.004304434492974671 0.024785863093492313 1.1064247664892872e-07 6.956078111433407 -0.5741120881723247 GLCAIAQAESLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLCAIAQAESLR 12 0 P23396;P23396-2;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 0 103439000.0 34331000.0 33510000.0 35598000.0 False True 45008273.46187697 28510438.62095695 31914660.440127973 1.0 0.6334488401361571 0.7090843079586338 25.42368688754947 -10.26418546431933 7.042906997135368 1.000002160580492 0.6712665740473984 0.9618130301612146 0.030878050436960614 1.0475509309953633e-06 1.094348079305433e-07 0.029897740209339663 0.00996584792547509 5.442701740560307e-11 10.26418546431933 -0.32873558653309365 GLCAIAQAESLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLCAIAQAESLR 12 0 P23396;P23396-2;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 0 32779600.0 15932000.0 4194600.0 12653000.0 False True 15426247.380735882 5869525.654550031 9338799.718136521 1.0 0.3804895325275171 0.6053837649329225 23.878883815968177 -10.16784072793334 5.333272792311595 1.000018489698006 0.4929366487300762 0.8714335294485989 0.0918126859152574 2.018571212997524e-05 3.1496735670948347e-06 0.08890048772274622 0.029632416959948327 6.79452767730979e-11 10.16784072793334 -0.5070818409679299 GLCAIAQAESLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLCAIAQAESLR 12 0 P23396;P23396-2;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 0 107205000.0 15844000.0 75447000.0 15914000.0 False True 24036506.35155503 61982893.379898496 12768590.924646007 1.0 2.5786981050134408 0.5312165893784289 24.518723883240504 -6.700746730901561 1.82792757031077 1.9795559161996634 0.5371586342611262 0.421294674125566 0.6662925987010911 0.3939473697294621 2.5595357386932123 0.2907219148287289 0.7470490631218856 1.9918345857967585e-07 6.700746730901561 -1.4423972819385371 GLCAIAQAESLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLCAIAQAESLR 12 0 P23396;P23396-2;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 0 86439000.0 34331000.0 23477000.0 28631000.0 False True 47024098.46039052 22439708.5119429 21868947.473954313 1.0 0.4771959324397124 0.46505830393271713 25.48689694907236 GLCAIAQAESLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLCAIAQAESLR 12 0 P23396;P23396-2;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 0 30434100.0 15932000.0 5204000.0 9298100.0 False True 13248163.907271747 5175965.019086871 11242289.720443008 1.0 0.3906930088814685 0.8485922878922308 23.659289091402453 -9.868199049899262 6.4217520702925714 1.0000000205138293 0.6196426483868472 0.47916357450280533 0.18693659786093547 5.4936159619608417e-08 9.659940152324581e-09 0.1810005933664087 0.060333527525983296 1.3545684316122754e-10 9.868199049899262 -0.38035737212698206 GLCAIAQAESLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLCAIAQAESLR 12 0 P23396;P23396-2;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 0 58695000.0 15844000.0 26647000.0 16204000.0 False True 20510370.331931695 25164071.02540446 13255038.267080454 1.0 1.2268950105804586 0.646260308934757 24.289850205332954 -6.800733365541812 1.4530501152776172 1.125071290657664 0.6381113120116191 0.8342639027751423 0.09726646210144721 0.21971198467060749 0.9157766974576491 0.05266073340325238 0.12240783126092519 1.582219142250726e-07 6.800733365541812 -0.486959978646045 GLCGAIHSSIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLCGAIHSSIAK 12 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 70777000.0 24678000.0 20902000.0 25197000.0 False True 32353096.982091952 17783503.075357858 22589856.146690924 1.0 0.5496692661355221 0.6982285547252195 24.947400484214498 -10.38077042234038 5.137147659686562 1.0002478409560165 0.623948910430345 0.8952159893644593 0.060649075599361994 0.00017226753590496877 2.0764959154200057e-05 0.05876140647039077 0.019574404979920666 4.1613052815453844e-11 10.38077042234038 -0.37629893052567154 GLCGAIHSSIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLCGAIHSSIAK 12 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 26356800.0 10862000.0 3011800.0 12483000.0 False True 10517191.755558202 4214427.4463295145 9213327.81802719 1.0 0.40071794299103114 0.8760254668893019 23.326246199528192 -10.006279705444799 7.006167838629955 1.0000000394540172 0.638371704940187 0.4356075290205845 0.19404348407608207 1.1947035159147082e-07 1.718275604369822e-08 0.18788181516420413 0.06262726518889399 9.856444811881814e-11 10.006279705444799 -0.36162833451383014 GLCGAIHSSIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLCGAIHSSIAK 12 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 50960000.0 10379000.0 25683000.0 14898000.0 False True 15745701.806538096 21099667.98780513 11953403.76997463 1.0 1.3400271545244116 0.7591534449745017 23.90845472592416 -6.748039813825386 1.6570055414775597 1.20040949568745 0.7581632931615541 0.6405221967001524 0.14287036191795907 0.30348144831040796 1.6388026939147866 0.06812826071572664 0.1657449070040489 1.78632380660918e-07 6.748039813825386 -0.44224620252589597 GLCGAIHSSIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLCGAIHSSIAK 12 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 52897000.0 24678000.0 12354000.0 15865000.0 False True 33802123.49787411 11808159.430785142 12118013.74993135 1.0 0.3493318824046005 0.3584985940511542 25.01061054573739 -10.313327401608365 5.724548423656046 1.0000757528466444 0.3539152382278737 0.9998490459123538 0.0037422943588958212 3.618516996219541e-06 4.3404745454964145e-07 0.003623882110414491 0.0012078203107152583 4.860406560435019e-11 10.313327401608365 -0.6461605146187708 GLCGAIHSSIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLCGAIHSSIAK 12 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 22055100.0 10862000.0 6456000.0 4737100.0 False True 9032234.268188916 6421220.246584329 5727605.708124301 1.0 0.7109226860068887 0.6341294455012805 23.10665147496247 -13.999999999999998 0.18606600374886997 2.529154449294874 0.5768021296527654 0.9994920603215013 0.0035501940654020393 12.289317767436398 0.13678156345453024 6.804765522388618 0.05451222202924475 1.0000000000000041e-14 13.999999999999998 -1.9523523196421084 GLCGAIHSSIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLCGAIHSSIAK 12 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 45282000.0 10379000.0 20082000.0 14821000.0 False True 13435820.100676533 18964419.046503235 12123730.076302122 1.0 1.4114820609683751 0.9023438826552654 23.67958104801661 -6.6917002264986865 1.86074229193685 1.2575689795459568 0.9040852641332376 0.37821667127091085 0.17396943664938885 0.4130310839461291 2.7740397864965196 0.07476412211404676 0.19424837522586816 2.0337603377533512e-07 6.6917002264986865 -0.35348371541271917 GLCGTVLIHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLCGTVLIHK 10 0 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 54829700.0 16474700.0 19956300.0 18398700.0 False True 21598491.241221722 16978897.829048112 16494979.016792582 1.0 0.7861149947660742 0.7637097810476294 24.364427200913646 -13.999999999999998 0.31874515139320236 3.1767763862152854 0.7591991130509388 0.999691028037521 0.0018720200518785484 17.916521238392303 0.17999310950535577 25.990206641567436 0.007496328877909483 1.0000000000000041e-14 13.999999999999998 -2.417577273164347 GLCGTVLIHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLCGTVLIHK 10 0 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 18580620.0 8680300.0 2282720.0 7617600.0 False True 8404748.627855992 3194222.000227537 5622322.036898499 1.0 0.38004967687443697 0.6689458883117989 23.002773240805997 -10.472965334583037 6.218986852636806 1.0002509174650958 0.5244977825931637 0.7831791738727131 0.11794138444078982 0.00041052726412662394 3.4790440776888205e-05 0.11425503098249144 0.03806541814731876 3.3653843082532905e-11 10.472965334583037 -0.47575313487193205 GLCGTVLIHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLCGTVLIHK 10 0 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 45579000.0 10707600.0 19537100.0 15334300.0 False True 16244212.030415945 16050551.860940965 12303468.883737538 1.0 0.9880782047714984 0.7574063217532687 23.95342242773842 -6.9176134776498985 0.8422353264829149 1.0055404504791103 0.72217614973262 0.9934919397544797 0.009007563460410106 0.09959646720081133 0.11304011196198639 0.007664412939031176 0.02246000658758057 1.2088892686437278e-07 6.9176134776498985 -0.2833643007464903 GLCGTVLIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLCGTVLIHK 10 0 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 49892900.0 16474700.0 14297600.0 19120600.0 False True 22565841.802027147 13665884.756159438 14604708.081118021 1.0 0.6056004857275831 0.6472042217279943 24.427637262436537 -10.142859538009683 7.929086327491947 1.0000000597123069 0.6264023540728307 0.9907849622045314 0.01698465409907776 1.791485632083162e-08 1.9470629347608518e-09 0.016445323067229678 0.005481773538901816 7.196817039149995e-11 10.142859538009683 -0.37359770563947614 GLCGTVLIHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLCGTVLIHK 10 0 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 17837200.0 8680300.0 2005200.0 7151700.0 False True 7218054.052491271 1994397.5895989633 8647087.404275315 1.0 0.27630682384687993 1.197980417075267 22.783178516240273 -6.697299166721514 1.8405388268144929 0.5494329972596751 1.1951016001246038 0.40477348380104883 0.3056330488701112 0.4011561870028506 2.640073862156397 0.1325736876280156 0.3420810549266822 2.0077093118677509e-07 6.697299166721514 0.6456686028649287 GLCGTVLIHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLCGTVLIHK 10 0 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 46586400.0 10707600.0 21611400.0 14267400.0 False True 13861199.278350888 20408706.592052598 11670879.595886443 1.0 1.4723622525164857 0.8419819498673975 23.72454874983087 -6.706166179697429 1.808914621559723 1.2915286139684758 0.8436264203673652 0.44686638140877966 0.1991744051446016 0.3828298052459162 2.4394343719805476 0.0877038369022782 0.22384732739187577 1.967133436048011e-07 6.706166179697429 -0.4479021936011106 GLCLLEQIDSFKPPQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLCLLEQIDSFKPPQR 16 1 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;H0YES5 Q9Y450 HBS1L HBS1-like protein 0 7500400.0 1537500.0 3758700.0 2204200.0 False True 2015677.3891711803 3197916.611297848 1976130.5281793943 1.0 1.5865220438935363 0.9803803618554023 20.942833322106924 -6.653680990973552 1.9953506301354058 1.3794890264439987 0.982929027716806 0.20905044378521953 0.25011075513821446 0.4996321378181045 3.8170201792212555 0.1015098379431335 0.2771004844357856 2.2198263844088692e-07 6.653680990973552 -0.3965599987271927 GLCLLEQIDSFKPPQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLCLLEQIDSFKPPQR 16 1 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;H0YES5 Q9Y450 HBS1L HBS1-like protein 0 33577000.0 10688000.0 12457000.0 10432000.0 False True 16214477.39746402 10233951.023014763 8370110.627491969 1.0 0.6311613240532424 0.5162121739921801 23.950779189809936 -13.999999999999998 0.16323508536294415 2.8294489138708854 0.4071501530372996 0.9995282351670687 0.004482434374158885 12.032822956092883 0.12777937905400646 6.96860006901325 0.099819622023757 1.0000000000000041e-14 13.999999999999998 -2.422298760833586 GLCLLEQIDSFKPPQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLCLLEQIDSFKPPQR 16 1 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;H0YES5 Q9Y450 HBS1L HBS1-like protein 0 10190500.0 1537500.0 4450600.0 4202400.0 False True 2105955.299375211 4253957.775833925 3209879.6711447523 1.0 2.0199658449996436 1.5241917395383704 21.006043383629816 -10.168778365668198 4.701838114261028 0.9999046343608204 1.7720787922748449 0.7637977329914212 0.20239893103083256 141846552.55825275 26.5330787913267 146451.85351121696 0.06928653758481697 6.779874179515703e-11 10.168778365668198 0.7721741579140244 GLCLLEQIDSFKPPQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLCLLEQIDSFKPPQR 16 1 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;H0YES5 Q9Y450 HBS1L HBS1-like protein 0 6578800.0 2996600.0 1172000.0 2410200.0 False True 2491805.6718886876 1165686.2033762133 2914161.6764943083 1.0 0.4678078296902946 1.169497970636487 21.248760130810382 -6.70389614081718 1.8169718326423128 0.6708015832471569 1.1675713499092655 0.43610523138067625 0.2244885189527309 0.3874631623075062 2.4894868426061936 0.09846722413243959 0.2520212575077489 1.9774424782738726e-07 6.70389614081718 0.4967697666621086 GLCLLEQIDSFKPPQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLCLLEQIDSFKPPQR 16 1 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;H0YES5 Q9Y450 HBS1L HBS1-like protein 0 23776100.0 10688000.0 6255400.0 6832700.0 False True 13835826.691977136 5907281.491061466 5589218.70942241 1.0 0.42695544130275 0.4039670945476198 23.721905511902385 GLDGIK(ub)ELEIGQAGSQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLDGIKELEIGQAGSQR 17 1 Q15021 Q15021 NCAPD2 Condensin complex subunit 1 1 4875650.0 1245300.0 832350.0 2798000.0 True False 1205768.6331427554 1164711.6956479084 2065119.8617992543 1.0 0.9659495724417422 1.7126999368167817 20.20152167404139 -6.8962162448579845 0.9848656009063991 0.9656468793555558 1.78533278296696 0.9845878791121325 0.0427403988829447 0.11424588420702153 0.19353873449622427 0.032765144025245975 0.08374196121750954 1.2699416156504123e-07 6.8962162448579845 0.8196859036114043 GLDGIK(ub)ELEIGQAGSQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLDGIKELEIGQAGSQR 17 1 Q15021 Q15021 NCAPD2 Condensin complex subunit 1 1 6896600.0 1245300.0 3735500.0 1915800.0 True False 1035522.1261439552 3715376.1200613063 2316384.9223416317 1.0 3.5879253820451984 2.2369246043706603 19.981926949475667 -9.966580686919551 10.902099314353231 1.0000218161961243 2.9124249932079294 0.7276505501954076 0.5515437580448023 0.0 0.0 0.534029947338057 0.17800998244601898 1.0799889527159972e-10 9.966580686919551 1.912403177011805 GLDGK(ub)VICGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLDGKVICGSR 11 1 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 1 2560460.0 1041500.0 978560.0 540400.0 True False 1365416.5859003467 832562.6623970043 484484.5918828347 1.0 0.6097499261355596 0.3548254773566916 20.380909751033606 -8.379710646956298 0.1818596104566109 1.3333073612866773 2.56639888978393e-09 0.9998195341056038 0.0035641825561720897 0.1116272690972143 0.04226320969700337 0.13644802272463005 0.12763118894164008 4.171472194130786e-09 8.379710646956298 -1.3333073587202784 down GLDGK(ub)VICGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLDGKVICGSR 11 1 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 1 2116900.0 1041500.0 0.0 1075400.0 True False 1426570.6954792072 0.0 821412.6685582218 1.0 0.0 0.5757952768560808 20.444119812556497 -9.991206469450358 6.228422072115604 1.0000003709800316 0.28789763842800853 0.6709800584247194 0.23506743743377687 1.2108319061680514e-06 1.963025399799583e-07 0.2276031879975537 0.07586768920137239 1.0204542306733952e-10 9.991206469450358 -0.712102732552023 GLDGK(ub)VICGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLDGKVICGSR 11 1 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 1 3932300.0 1388400.0 1253600.0 1290300.0 True False 1154516.1165488402 1246846.6079798827 1560095.7643268628 1.0 1.079973323981863 1.3512983855005936 20.138856881979553 -6.9486583792880445 0.5733920726197264 0.9966699280194731 1.4478702806507942 0.9990916830203914 0.004531038506261495 0.08402915896916537 0.03822805816461534 0.004781993629918996 0.02262583892418652 1.1254899483584131e-07 6.9486583792880445 0.4512003526313211 GLDISNVK(ub)HVINFDLPSDIEEYVHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLDISNVKHVINFDLPSDIEEYVHR 25 1 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 1 62177400.0 5195400.0 10615000.0 46367000.0 True False 7881801.6346168155 8720670.314626452 37202542.12662192 1.0 1.1064310824983632 4.720055623225612 22.91009401020365 -6.913193915809099 0.8737077958650643 0.8990983757089805 5.220414490908501 0.9920719869426974 0.1539589896466885 0.10234347570792618 0.1275930084655201 0.12807376330618792 0.36187434248654754 1.2212542390446315e-07 6.913193915809099 4.3213161151995205 up GLDISNVK(ub)HVINFDLPSDIEEYVHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLDISNVKHVINFDLPSDIEEYVHR 25 1 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 1 49428800.0 5195400.0 5853400.0 38380000.0 True False 6725547.716644647 5527653.144447869 31395233.812055584 1.0 0.8218889192872453 4.668056065435004 22.6812203322961 -6.896043857938178 0.9859576817328524 0.8222744522818713 5.040827441828172 0.9844926075047378 0.22074096020629724 0.11437557802066473 0.19430533185217194 0.16908799507416752 0.4318164260248017 1.270445800684203e-07 6.896043857938178 4.218552989546301 up GLDLSSGLVVTSLCK(ub)SSSLPASQNNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLDLSSGLVVTSLCKSSSLPASQNNLR 27 1 H3BU49;Q9Y2Y0-2;Q9Y2Y0 H3BU49 ARL2BP ADP-ribosylation factor-like protein 2-binding protein 1 6947400.0 5081600.0 1865800.0 0.0 True False 4225575.553049976 1855748.5650676962 0.0 1.0 0.4391706033343165 0.0 22.010716429293865 -8.131891909090612 0.5576964889530239 1.0221026633041501 1.3637612947651897e-16 0.9906598198459752 0.0395522036084698 0.11908239713412626 0.1703008280212737 0.05055016437702535 0.07422552999557278 7.380879088751808e-09 8.131891909090612 -1.02210266330415 GLDNTEFQGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLDNTEFQGKR 11 1 Q9BQ04;Q9BWF3;E9PB51 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 1 10646230.0 2775500.0 2869830.0 5000900.0 True False 3638707.377980235 2441662.5505097248 4483454.840020107 1.0 0.6710247065442885 1.2321559208503248 21.794994604754542 -6.74779074745569 1.6579694495867223 0.806054166802047 1.233092126064852 0.639501064616451 0.13822451722551773 0.30387879511535854 1.6427856574001136 0.06587795361170738 0.16030985203484607 1.7873485508935985e-07 6.74779074745569 0.42703795926280497 GLDNTEFQGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLDNTEFQGKR 11 1 Q9BQ04;Q9BWF3;E9PB51 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 1 8035670.0 2069700.0 3269970.0 2696000.0 True False 2003998.5063965034 4575686.073668273 1989836.7217336628 1.0 2.2832781856190394 0.9929332359192694 20.93445000260023 -6.647348003690829 2.0172986321457103 1.8344019070133788 0.9982649169470418 0.18373071401116026 0.5480628171385763 0.5149921811903887 4.013747095521531 0.22053107335994945 0.6072493514306312 2.2524335955122703e-07 6.647348003690829 -0.836136990066337 GLDNTEFQGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLDNTEFQGKR 11 1 Q9BQ04;Q9BWF3;E9PB51 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 1 58047200.0 8311800.0 10508000.0 39227400.0 True False 12609608.2739747 8632765.300621271 31474087.196019784 1.0 0.6846180399147419 2.4960400443985225 23.588020122274795 -6.861980100060661 1.1755995927411353 0.8278867439818043 2.5871719330801404 0.9560076117319912 0.1657262423255256 0.14478103553298077 0.37908101834450114 0.10985427343671549 0.257047260816343 1.3741049368495978e-07 6.861980100060661 1.759285189098336 up GLDNTEFQGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLDNTEFQGKR 11 1 Q9BQ04;Q9BWF3;E9PB51 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 1 15434200.0 2069700.0 5775800.0 7588700.0 True False 1721047.2532563626 5744684.6189934565 9175462.083815606 1.0 3.337900576596047 5.33132490491175 20.714855278034506 -7.484192118996582 0.2335438321867392 4.014734027723191e-25 7.699572953901449 0.9999014760614128 0.017570064289101173 0.1326187447165614 0.022973078724874543 0.1919715923063813 0.44952736778426144 3.279501855855357e-08 7.484192118996582 7.699572953901449 GLDNTEFQGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLDNTEFQGKR 11 1 Q9BQ04;Q9BWF3;E9PB51 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 1 52413400.0 8311800.0 2146600.0 41955000.0 True False 10759788.950072575 2027139.8229869476 34319620.4946532 1.0 0.18839958965675385 3.189618370202486 23.359146444367244 -6.834695483120132 1.3068412198345298 0.5675510679286387 3.2783795486627954 0.914936949411612 0.3696919091188124 0.17508682484875107 0.5831276655370546 0.22199988207970164 0.5109334612633905 1.4632027775624894e-07 6.834695483120132 2.7108284807341567 GLDTVVALLADVVLQPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLDTVVALLADVVLQPR 17 0 Q10713 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 63325900.0 17227000.0 39642000.0 6456900.0 False True 26134618.462398242 32567575.375640277 5180690.884840194 1.0 1.2461469610699538 0.19823097445612328 24.639458761851646 -6.8447964777204025 1.2599021100667325 1.1309824210810593 0.1603529875987581 0.9323910440394321 0.11633328634419578 0.16327436712184132 0.501358421440326 0.07233816377316621 0.16693431724227428 1.4295637342500987e-07 6.8447964777204025 -0.9706294334823011 down GLDVK(ub)SEACQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLDVKSEACQR 11 1 Q93008;Q93008-3;O00507;O00507-2 Q93008 USP9X;USP9Y Probable ubiquitin carboxyl-terminal hydrolase FAF-X;Probable ubiquitin carboxyl-terminal hydrolase FAF-Y 1 19106200.0 5246300.0 7192200.0 6667700.0 True False 6877950.105241473 6119151.794976026 5977790.365094697 1.0 0.889676677112387 0.8691238339369761 22.713547219474748 -13.99999999999995 0.2363113687715027 1.7174011589129292 0.8597126165636214 0.9995190227995238 0.0012603091812619762 13.496162636357958 0.15387877467058658 4.559241226207123 0.010265334399606406 1.0000000000001145e-14 13.99999999999995 -0.8576885423493078 GLDVK(ub)SEACQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLDVKSEACQR 11 1 Q93008;Q93008-3;O00507;O00507-2 Q93008 USP9X;USP9Y Probable ubiquitin carboxyl-terminal hydrolase FAF-X;Probable ubiquitin carboxyl-terminal hydrolase FAF-Y 1 6129960.0 1610100.0 2231400.0 2288460.0 True False 1558988.2568241814 3122409.656597274 1689043.6736715927 1.0 2.0028436025284386 1.0834229611917332 20.57217863021085 -6.625504508436332 2.0965497311893544 1.6628293105429914 1.0870332809425336 0.10162324669871725 0.4306550724749166 0.5708019016656979 4.77501704668241 0.16834020824807874 0.477289126638267 2.3686205428685838e-07 6.625504508436332 -0.5757960296004578 GLDVK(ub)SEACQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLDVKSEACQR 11 1 Q93008;Q93008-3;O00507;O00507-2 Q93008 USP9X;USP9Y Probable ubiquitin carboxyl-terminal hydrolase FAF-X;Probable ubiquitin carboxyl-terminal hydrolase FAF-Y 1 27837900.0 6498900.0 16033000.0 5306000.0 True False 9859306.43323156 13171785.883599237 4257266.774297585 1.0 1.3359748956785344 0.43180185169497676 23.233054731086487 -6.806079074960062 1.4308257158621054 1.1839734886993243 0.41734539404723914 0.8493658117472069 0.14483069605313206 0.21220134093854842 0.8569068779294028 0.07960564466008001 0.1845033654896901 1.5628630555914606e-07 6.806079074960062 -0.7666280946520851 down GLDVK(ub)SEACQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLDVKSEACQR 11 1 Q93008;Q93008-3;O00507;O00507-2 Q93008 USP9X;USP9Y Probable ubiquitin carboxyl-terminal hydrolase FAF-X;Probable ubiquitin carboxyl-terminal hydrolase FAF-Y 1 16655800.0 5246300.0 5431100.0 5978400.0 True False 7185998.8859266145 5191136.043754025 4566425.0490129 1.0 0.7223958876365234 0.6354614190041128 22.77675728099764 -13.999999999999998 0.1625390772426711 2.374753460684201 0.5523503468917943 0.999529920133772 0.0033705716992799314 12.02763238646878 0.1274868170005142 5.212118290411663 0.07599745139679231 1.0000000000000041e-14 13.999999999999998 -1.8224031137924068 GLDVK(ub)SEACQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLDVKSEACQR 11 1 Q93008;Q93008-3;O00507;O00507-2 Q93008 USP9X;USP9Y Probable ubiquitin carboxyl-terminal hydrolase FAF-X;Probable ubiquitin carboxyl-terminal hydrolase FAF-Y 1 11282100.0 1610100.0 1828700.0 7843300.0 True False 1338869.4895241184 1818848.4301314682 9483297.7666782 1.0 1.3584956893580056 7.083063615146611 20.352583905645126 -6.919679722274487 0.8270973207636019 0.8722265730841613 7.999439333993429 0.9940914996466023 0.21422238522009557 0.09836069622033738 0.10659311294388508 0.18426193985081413 0.5502746274527603 1.203151391632677e-07 6.919679722274487 7.127212760909268 up GLDVK(ub)SEACQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLDVKSEACQR 11 1 Q93008;Q93008-3;O00507;O00507-2 Q93008 USP9X;USP9Y Probable ubiquitin carboxyl-terminal hydrolase FAF-X;Probable ubiquitin carboxyl-terminal hydrolase FAF-Y 1 16384200.0 6498900.0 8674500.0 1210800.0 True False 8412954.162471017 8191756.449501657 990446.8238571349 1.0 0.9737074862530345 0.11772877930030527 23.004181053178936 -6.915121175303144 0.8736541648061276 1.0235700799211367 1.0709279456484167e-16 0.992165744138539 0.03627637066130071 0.10168194594458281 0.1268947601186827 0.03021732189486007 0.08509223795021165 1.2158467120857385e-07 6.915121175303144 -1.0235700799211367 down GLDVPQVSLIINYDLPNNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLDVPQVSLIINYDLPNNR 19 0 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 177756000.0 42599000.0 59420000.0 75737000.0 False True 64625797.40405782 48816036.749420986 60767548.7532937 1.0 0.7553645558013007 0.9402986298700298 25.94560684085818 -10.177404574129271 6.117431786105845 1.0000014130354762 0.8478315930315105 0.4744370464033093 0.07549901958707907 1.4550079123964635e-06 1.956967824279555e-07 0.07310228998835172 0.024367203792978298 6.646536986875192e-11 10.177404574129271 -0.15216982000396573 GLDVPQVSLIINYDLPNNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLDVPQVSLIINYDLPNNR 19 0 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 90634000.0 42599000.0 16311000.0 31724000.0 False True 55145245.25182768 15403278.511478677 25950557.51572826 1.0 0.2793219694850875 0.47058558534324735 25.71673316295063 -10.354887452010395 4.978794207504016 1.000383733325884 0.37495377741446945 0.9343815490597227 0.07808304420251228 0.0003327899072818044 4.312027525629162e-05 0.07564851114461077 0.025201194151390105 4.4168489574807667e-11 10.354887452010395 -0.6254299559114146 GLEAICAK(ub)FTHESQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLEAICAKFTHESQR 15 1 A0A0A0MTI1;Q15392;Q15392-2 A0A0A0MTI1 DHCR24 Delta(24)-sterol reductase 1 13006700.0 1120200.0 1541500.0 10345000.0 True False 1468593.0480322319 1311514.2087199371 9274598.63624709 1.0 0.8930412754419853 6.315295206302472 20.486003245052956 -6.902402910915196 0.9459698036643789 0.7891841898609241 6.913025082747336 0.9877238453765426 0.28045598759452434 0.10965751302152096 0.16761977509161302 0.2213161441096655 0.5830771196389823 1.2519791290439672e-07 6.902402910915196 6.123840892886412 up GLEAICAK(ub)FTHESQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLEAICAKFTHESQR 15 1 A0A0A0MTI1;Q15392;Q15392-2 A0A0A0MTI1 DHCR24 Delta(24)-sterol reductase 1 208017800.0 2432800.0 72045000.0 133540000.0 True False 3690735.461503598 59188006.859845795 107145760.46733886 1.0 16.03691390976386 29.0310052250908 21.81547690347932 -7.795513336342605 0.39523741092887676 3.375584889288951e-16 34.03691417284576 0.9968987402380942 0.637846547574056 0.13853479426054488 0.08543328055598802 1.33427629181948 3.106449809954689 1.6013514731863126e-08 7.795513336342605 34.03691417284576 GLEAICAK(ub)FTHESQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLEAICAKFTHESQR 15 1 A0A0A0MTI1;Q15392;Q15392-2 A0A0A0MTI1 DHCR24 Delta(24)-sterol reductase 1 22932500.0 1120200.0 1234300.0 20578000.0 True False 1534368.2122667392 1179764.5447157288 15717900.217213219 1.0 0.7688927177218104 10.243890672104703 20.549213306575847 -6.901311816909054 0.952958951543851 0.6201183762429864 11.26530099076794 0.9872071309782878 0.49914538524814156 0.11044539844538544 0.17203311633925744 0.39185957600584487 1.026403678384642 1.2551284767292003e-07 6.901311816909054 10.645182614524954 up GLEAICAK(ub)FTHESQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLEAICAKFTHESQR 15 1 A0A0A0MTI1;Q15392;Q15392-2 A0A0A0MTI1 DHCR24 Delta(24)-sterol reductase 1 130703800.0 2432800.0 42794000.0 85477000.0 True False 3149307.55765737 40412476.28105073 69921063.06808423 1.0 12.832178357045501 22.202043397785957 21.586603225571768 -7.917453210185368 0.3905183872155823 5.3928126339933114e-18 25.646049338331608 0.9969620371692587 0.4781535572764695 0.12090845103157008 0.09026327041883879 1.1673648004738328 2.2843252142920965 1.2093354667405913e-08 7.917453210185368 25.646049338331608 GLEEK(ub)PGGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLEEKPGGDK 10 1 F5GZ90;Q9NZJ0 F5GZ90 DTL Denticleless protein homolog 1 1681190.0 432320.0 307780.0 941090.0 True False 592160.3870087096 294181.2619076456 718823.9243569426 1.0 0.49679321407110394 1.2139007271122477 19.17562845806681 -6.718098548518725 1.7661818024434046 0.6932355237170383 1.212663626205461 0.503524342382142 0.21180201550175806 0.35902182906474495 2.1876747814685777 0.09525789763865439 0.23966719486036564 1.9138215983330986e-07 6.718098548518725 0.5194281024884227 GLEISGTFTHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLEISGTFTHR 11 0 P63010;P63010-2;A0A087X253;P63010-3 P63010 AP2B1 AP-2 complex subunit beta 0 6101000.0 2542900.0 3558100.0 0.0 False True 3483078.849288602 3400891.376936754 0.0 1.0 0.9764037864463981 0.0 21.73193170207943 -7.042351587134554 1.0612267820725665 1.0149751841157897 6.208155730217077e-19 0.9873847396263002 0.05233357067626821 0.08582084694706921 0.18656168875011953 0.04141172468051664 0.07439817210615106 9.070858930361528e-08 7.042351587134554 -1.0149751841157897 down GLEQGNLK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLEQGNLKK 9 1 Q9Y5T5-2;Q9Y5T5;Q9Y5T5-3;Q9Y5T5-5;H9KVB6 Q9Y5T5-2 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 7282800.0 2117700.0 2535300.0 2629800.0 True False 2776325.207835971 2157043.1225219998 2357693.5228228695 1.0 0.7769418065412173 0.8492137434650866 21.404745138772206 -10.33365315076474 7.886131840905325 1.00000103935004 0.8130777750031519 0.8991844398556592 0.0295048946976818 5.391679346134876e-07 4.55599314279896e-08 0.028568150224148707 0.009522663816310435 4.638171994047102e-11 10.33365315076474 -0.1869232643468881 GLEQGNLK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLEQGNLKK 9 1 Q9Y5T5-2;Q9Y5T5;Q9Y5T5-3;Q9Y5T5-5;H9KVB6 Q9Y5T5-2 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 8194600.0 2117700.0 2898700.0 3178200.0 True False 2900670.918690654 2770625.849280952 2427574.6170836324 1.0 0.9551672447323313 0.8369010774167466 21.467955200295098 -6.954300644097216 0.509447149083772 1.0021865240798957 0.7846981679079847 0.9994969868698538 0.0015429810341257401 0.08180340673919853 0.029160799488535196 0.0017789124337682692 0.009760434828901425 1.1109623877357803e-07 6.954300644097216 -0.21748835617191098 GLEVINDYHFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLEVINDYHFR 11 0 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18;H3BVE6;Q6K0P9-6;Q6K0P9-4;Q6K0P9-3;Q6K0P9-2;Q6K0P9-5;X6RHR0;Q6K0P9 Q16666 IFI16;PYHIN1 Gamma-interferon-inducible protein 16;Pyrin and HIN domain-containing protein 1 0 7294000.0 1821900.0 2336700.0 3135400.0 False True 2388528.543304699 1988073.4683852585 2810978.88488053 1.0 0.8323423531856218 1.17686635680365 21.187690686676827 -6.774385533157607 1.5577241778562032 0.9043754721918179 1.1791310543816327 0.7470287340737254 0.07075076857751449 0.25939768705785743 1.2427614798215065 0.03578861571281019 0.08485171971411753 1.6811809755917336e-07 6.774385533157607 0.2747555821898148 GLEVINDYHFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLEVINDYHFR 11 0 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18;H3BVE6;Q6K0P9-6;Q6K0P9-4;Q6K0P9-3;Q6K0P9-2;Q6K0P9-5;X6RHR0;Q6K0P9 Q16666 IFI16;PYHIN1 Gamma-interferon-inducible protein 16;Pyrin and HIN domain-containing protein 1 0 6201400.0 1821900.0 1927600.0 2451900.0 False True 2495505.6649962263 1842432.2582792146 1872811.718465596 1.0 0.7383001706317508 0.7504738397251557 21.25090074819972 -9.808090883059334 6.113982578571148 1.0000000131908076 0.7443870051812933 0.9983017531755557 0.004969879596975494 8.919222633423852e-10 1.7592141849562142e-10 0.0048120654426464385 0.0016040217425101755 1.5556400550032615e-10 9.808090883059334 -0.25561300800951425 GLEVNK(ub)CEIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLEVNKCEIAR 11 1 P31146;H3BRY3 P31146 CORO1A Coronin-1A;Coronin 1 7060400.0 2501200.0 2817300.0 1741900.0 True False 3279097.421655253 2396969.8217493882 1561664.8974846585 1.0 0.730984631905027 0.47624839907816674 21.64486733401673 -6.971785966952017 0.21121781280305865 1.1313144937385364 0.06879751612809953 0.9999931636567656 0.0005591036248721001 0.07572735447142101 0.006916943378529952 0.007554935742278155 0.026322995823190913 1.0671219006052402e-07 6.971785966952017 -1.0625169776104368 down GLEVNK(ub)CEIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLEVNKCEIAR 11 1 P31146;H3BRY3 P31146 CORO1A Coronin-1A;Coronin 1 4330400.0 1592800.0 1440800.0 1296800.0 True False 1542237.4358546399 2016118.9536727408 957129.176833908 1.0 1.3072688464182538 0.6206107792367971 20.55659346243713 -6.785047945084481 1.5160021527041072 1.1728440650064056 0.6142657601520286 0.7849009397753317 0.1302510342145682 0.24281338176301512 1.1024498054711178 0.06764713423335397 0.15897244637853067 1.6404086659626942e-07 6.785047945084481 -0.558578304854377 GLEVNK(ub)CEIAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLEVNKCEIAR 11 1 P31146;H3BRY3 P31146 CORO1A Coronin-1A;Coronin 1 22108200.0 5210300.0 2663900.0 14234000.0 True False 7904406.023952732 2188506.2318543014 11420643.661016168 1.0 0.27687168716061245 1.4448452706513528 22.914225624761226 -6.739230211336836 1.6894749332157972 0.5693623535898815 1.4454221261251052 0.6015125353359017 0.30383330283443755 0.3192038478735438 1.7886701275473822 0.14228674028705743 0.3494597211950908 1.822929145710244e-07 6.739230211336836 0.8760597725352237 GLEVNK(ub)CEIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLEVNKCEIAR 11 1 P31146;H3BRY3 P31146 CORO1A Coronin-1A;Coronin 1 7181400.0 2501200.0 1972300.0 2707900.0 True False 3425961.2323884703 1885157.2644760818 2068349.7909510941 1.0 0.5502564496801998 0.603728311750074 21.708077395539622 -10.130089924393232 6.682362430577648 1.000000650558344 0.5769923807162055 0.9881575456062125 0.02182979627794662 2.1156298843502782e-07 2.754934397858455e-08 0.02113664195513712 0.00704553645296551 7.411567625544829e-11 10.130089924393232 -0.4230082698421386 GLEVTAYSPLGSSDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLEVTAYSPLGSSDR 15 0 P14550 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 39971000.0 12665000.0 13453000.0 13853000.0 False True 16603937.648034481 11445864.83938329 12419624.44735919 1.0 0.6893464117975782 0.7479927177894085 23.985022083592824 -10.690387108698745 6.734700286955517 1.0023124198571691 0.7186695647934948 0.9684368398820642 0.023942254163185326 0.0008370459712375185 3.848128289884373e-05 0.023342541205920754 0.007727329303723498 2.039918850930032e-11 10.690387108698745 -0.28364285506367437 GLEVTAYSPLGSSDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLEVTAYSPLGSSDR 15 0 P14550 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 29983200.0 12818000.0 5115200.0 12050000.0 False True 12411099.606218474 7157726.035415603 8893743.50774876 1.0 0.5767197317334627 0.7165959334733425 23.565127606122996 -10.360333197887309 4.99819203537773 1.0002243974684264 0.6466578326033362 0.8948285581234761 0.05710422023711451 0.00014288069748955956 1.8285801619964325e-05 0.05532566302395927 0.01843030783134248 4.361810585346267e-11 10.360333197887309 -0.3535665648650902 GLEVTAYSPLGSSDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLEVTAYSPLGSSDR 15 0 P14550 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 66459000.0 14974000.0 36856000.0 14629000.0 False True 22716652.746035375 30278758.842757635 11737571.737881526 1.0 1.3328882199883976 0.5166945970915555 24.437246936446094 -6.795982396042543 1.4723789158904108 1.1846143183189284 0.5065289458691806 0.8201219696473445 0.1421186783091298 0.2265435508993601 0.9699804285463768 0.07595197351443843 0.17707678554403236 1.599622867389658e-07 6.795982396042543 -0.6780853724497478 GLEVTAYSPLGSSDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLEVTAYSPLGSSDR 15 0 P14550 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 38977000.0 12665000.0 11917000.0 14395000.0 False True 17347592.758755814 11390467.535750894 10995197.47433104 1.0 0.6566021980197689 0.6338169005484324 24.048232145115715 -13.999999999998012 0.38548411428167517 6.275433119089218 0.6320043793284095 0.9998162081952168 0.0022708999741125006 24.743501167084126 0.203037922342608 108.56735881112276 0.006076221841277942 1.000000000004577e-14 13.999999999998012 -5.643428739760808 GLEVTAYSPLGSSDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLEVTAYSPLGSSDR 15 0 P14550 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 24134800.0 12818000.0 5803700.0 5513100.0 False True 10658734.933681233 5772434.316155745 6665863.7203057 1.0 0.5415684274045556 0.6253897635864648 23.345532881557272 -10.83042638895193 7.3471527442319555 1.0236457765394138 0.5834790954955106 0.9705217233743271 0.03421991720066119 0.012075512411437716 0.0002787046475613661 0.030186773941762605 0.011044430785563119 1.4776569168615527e-11 10.83042638895193 -0.4401666810439032 GLEVTAYSPLGSSDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLEVTAYSPLGSSDR 15 0 P14550 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 46256000.0 14974000.0 20476000.0 10806000.0 False True 19384138.18166781 19336492.600149393 8839418.8789232 1.0 0.9975420325076162 0.4560129935146107 24.208373258538543 -6.907895813590037 0.9099447319451052 1.0179029231457104 0.3890901086665767 0.9901029845055745 0.025453965366067827 0.1058259667266807 0.14643666913067346 0.020625073125889796 0.05613772380447426 1.2362439704218468e-07 6.907895813590037 -0.6288128144791337 down GLFDEYGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLFDEYGSK 9 0 P14625;Q58FF3 P14625 HSP90B1;HSP90B2P Endoplasmin;Putative endoplasmin-like protein 0 16138600.0 6341000.0 2658200.0 7139400.0 False True 6139708.425887919 3719633.1223298735 5269376.9625909915 1.0 0.6058322096609895 0.8582454730867678 22.54973871310957 -10.089523994421628 4.984956267449283 1.0000077515539958 0.7320388413726681 0.6004236890120724 0.1030472832881746 8.877611165535613e-06 1.6216808831672768e-06 0.0997779880701305 0.03325836766998479 8.137219020547108e-11 10.089523994421628 -0.26796891018132774 GLFEEAAK(ub)LYDLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLFEEAAKLYDLAK 14 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BVE2 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 21246400.0 2389200.0 5108200.0 13749000.0 True False 3624591.073916644 4196601.7994512385 11031504.123599233 1.0 1.1578138647559195 3.04351688194135 21.789386808890182 -6.923455713968967 0.7986829515764016 0.9633442946314468 3.3731586492935763 0.9950882038074926 0.0650636757787928 0.0961807535830541 0.09539016430747241 0.05711064537324295 0.17715751414821237 1.1927358857418066e-07 6.923455713968967 2.40981435466213 up GLFIIDDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLFIIDDK 8 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5;Q13162;H7C3T4 Q06830;Q13162 PRDX1;PRDX4 Peroxiredoxin-1;Peroxiredoxin-4 0 87470000.0 12659000.0 37080000.0 37731000.0 False True 16596071.58993038 31547808.53670793 33826958.061308704 1.0 1.900920248852715 2.038250912452867 23.9843384498535 -10.928882743601314 0.35288958466515014 3.972050988599602e-09 2.0609361203271654 0.9993478048810789 0.01176011300551349 2.698310659529039 0.17495150171545798 2.259570267009296 0.04044540165006878 1.1779239616222271e-11 10.928882743601314 2.0609361163551143 GLFIIDDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLFIIDDK 8 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5;Q13162;H7C3T4 Q06830;Q13162 PRDX1;PRDX4 Peroxiredoxin-1;Peroxiredoxin-4 0 74875000.0 30029000.0 11369000.0 33477000.0 False True 29075745.832043566 15908700.988551786 24708369.41152737 1.0 0.5471467896455214 0.8497931421692704 24.793312863455686 -10.139683236084569 5.416907878801963 1.000006592857992 0.6984699659073064 0.5696176588819211 0.12355485603326023 9.837736486993259e-06 1.5624210291330907e-06 0.11963408929802911 0.039877158313276914 7.249645389262872e-11 10.139683236084569 -0.3015366269506856 GLFIIDDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLFIIDDK 8 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5;Q13162;H7C3T4 Q06830;Q13162 PRDX1;PRDX4 Peroxiredoxin-1;Peroxiredoxin-4 0 233430800.0 8467800.0 214480000.0 10483000.0 False True 12846271.67910235 176204368.26011118 8411030.455137879 1.0 13.716381893647114 0.6547448680242772 23.614846376896658 -6.652293106814741 2.0002583933143327 9.236774298379114 0.7096001509504457 0.20337390834916547 5.4244707905674545 0.5029828028097735 3.8599702029777085 2.1973305130555625 6.009414638840756 2.226931678256778e-07 6.652293106814741 -8.527174147428669 GLFIIDDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLFIIDDK 8 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5;Q13162;H7C3T4 Q06830;Q13162 PRDX1;PRDX4 Peroxiredoxin-1;Peroxiredoxin-4 0 96706000.0 12659000.0 42020000.0 42027000.0 False True 17339374.396611888 40163417.45844197 32101088.173234496 1.0 2.316312949923378 1.851340621580156 24.04754851137639 -10.26188047350222 5.152806346061346 0.9998295594620652 2.083826785752048 0.8787060017671421 0.1898241581601018 0.0003717373865307061 5.325014826786558e-05 0.18382458805702928 0.061265483605018996 5.471665333091245e-11 10.26188047350222 1.0839972262899829 GLFIIDDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLFIIDDK 8 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5;Q13162;H7C3T4 Q06830;Q13162 PRDX1;PRDX4 Peroxiredoxin-1;Peroxiredoxin-4 0 43965800.0 30029000.0 8350400.0 5586400.0 False True 24970444.010260075 8305414.737775382 6754490.411404782 1.0 0.33260981400101575 0.27049941156951146 24.573718138889962 -13.999999999999998 0.3359271653805687 8.530116647714715 0.2602485652219918 0.9997270086817016 0.005456126852783999 19.33626198270186 0.18567157412289956 103.18493109664968 0.01947336577095621 1.0000000000000041e-14 13.999999999999998 -8.269868082492723 GLFIIDDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLFIIDDK 8 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5;Q13162;H7C3T4 Q06830;Q13162 PRDX1;PRDX4 Peroxiredoxin-1;Peroxiredoxin-4 0 35766800.0 8467800.0 16891000.0 10408000.0 False True 10961734.025292298 15951001.001617692 8513850.795098329 1.0 1.4551530774979147 0.7766883209767813 23.385972698989107 -6.72594187189794 1.737843334617821 1.2751450128400486 0.7773714500526194 0.5403552378142338 0.19140553944440183 0.34393983177061377 2.0329888384976784 0.08734624963323065 0.2177618827382251 1.879568370611322e-07 6.72594187189794 -0.4977735627874291 GLFIIDDK(ub)GILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLFIIDDKGILR 12 1 Q06830;A0A0A0MSI0;A0A0A0MRQ5;Q13162;H7C3T4 Q06830;Q13162 PRDX1;PRDX4 Peroxiredoxin-1;Peroxiredoxin-4 1 4060900.0 1074000.0 1029300.0 1957600.0 True False 1408024.4006307963 875732.452179976 1755046.3306251636 1.0 0.6219582926174057 1.2464601677633578 20.425240904978374 -6.742821052144603 1.6761249588284168 0.7757976507913744 1.2470702416913126 0.6175425204072537 0.15883254275362133 0.31278623217546975 1.726407557871424 0.07492937362489774 0.18332094674410881 1.8079189122839155e-07 6.742821052144603 0.4712725908999382 GLFIIDDK(ub)GILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLFIIDDKGILR 12 1 Q06830;A0A0A0MSI0;A0A0A0MRQ5;Q13162;H7C3T4 Q06830;Q13162 PRDX1;PRDX4 Peroxiredoxin-1;Peroxiredoxin-4 1 10022900.0 1161600.0 2150100.0 6711200.0 True False 1124725.6438276921 3008646.1426233794 4953335.388315631 1.0 2.675004485880028 4.404038812041598 20.10114169471238 -6.9707272995921565 0.24018379599309256 0.38056603432835373 6.748498131265177 0.999987511924672 0.004911165473585432 0.07606743328923925 0.008181228972635016 0.041276722424847964 0.16850799019892987 1.0697263665695567e-07 6.9707272995921565 6.367932096936824 GLFIIDDK(ub)GILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLFIIDDKGILR 12 1 Q06830;A0A0A0MSI0;A0A0A0MRQ5;Q13162;H7C3T4 Q06830;Q13162 PRDX1;PRDX4 Peroxiredoxin-1;Peroxiredoxin-4 1 4426100.0 1074000.0 993400.0 2358700.0 True False 1471086.823758685 949508.303265499 1801623.638951344 1.0 0.6454468138321487 1.224688855786312 20.488450966501265 -6.741041655017429 1.682716395051915 0.7893027140863984 1.225118950488596 0.6097139478859299 0.14896494281528505 0.3159178919601658 1.756784944410692 0.07001973184907934 0.17163710010166464 1.815341537351171e-07 6.741041655017429 0.4358162364021976 GLFIIDDK(ub)GILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLFIIDDKGILR 12 1 Q06830;A0A0A0MSI0;A0A0A0MRQ5;Q13162;H7C3T4 Q06830;Q13162 PRDX1;PRDX4 Peroxiredoxin-1;Peroxiredoxin-4 1 7429700.0 1161600.0 2495900.0 3772200.0 True False 965921.8676052507 2482454.0913026375 4560949.579317835 1.0 2.5700361225460497 4.721861811272076 19.881546970146655 -6.966713627771994 0.32731225529691277 0.7294858899205221 6.632573074838884 0.9999442346206346 0.011392745347820893 0.0773841829022967 0.012834985030197074 0.03170630421211678 0.18809919678450043 1.0796584104558974e-07 6.966713627771994 5.903087184918363 GLFIIDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLFIIDGK 8 0 P32119 P32119 PRDX2 Peroxiredoxin-2 0 24038400.0 3395500.0 6873900.0 13769000.0 False True 4451533.382068774 5848340.914252344 12344315.9615743 1.0 1.3137812102701625 2.7730480493077847 22.08587094397698 -6.941433269178895 0.6460909364797643 0.9839394618421156 3.1837341987056895 0.9983456824727256 0.03142249915545043 0.08711878889947625 0.051677163339840036 0.03093046803659058 0.12482442210365963 1.1443707027511243e-07 6.941433269178895 2.199794736863574 up GLFIIDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLFIIDGK 8 0 P32119 P32119 PRDX2 Peroxiredoxin-2 0 15239600.0 5712100.0 3027300.0 6500200.0 False True 5530772.512145463 4236116.677160942 4797602.618179957 1.0 0.7659177208714545 0.8674380672219876 22.399049572678127 -10.148873047027596 4.629193033305953 1.0000194039172543 0.8166778940463412 0.8130046496666115 0.041445507864200086 9.003565715191018e-06 1.6553679877741823e-06 0.040134045606999805 0.013376480141602936 7.097852220719839e-11 10.148873047027596 -0.18334150987091313 GLFIIDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLFIIDGK 8 0 P32119 P32119 PRDX2 Peroxiredoxin-2 0 24186300.0 3395500.0 8707800.0 12083000.0 False True 4650908.1099372525 8323060.603156124 9229244.257196376 1.0 1.7895560192584443 1.984396173615413 22.14908100549987 -10.90756418764312 0.2716854059634475 3.1386464046215232e-09 2.061897930512234 0.9992010126326311 0.012030823758412114 2.763342592346035 0.1404874302087736 1.834396719767623 0.07967674443257215 1.2371883230682518e-11 10.90756418764312 2.061897927373588 GLFIIDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLFIIDGK 8 0 P32119 P32119 PRDX2 Peroxiredoxin-2 0 9692200.0 5712100.0 2145800.0 1834300.0 False True 4749864.238935917 2134240.1494920487 2217843.6491550542 1.0 0.4493265580091968 0.46692779784626104 22.179454848112403 -9.978868078591756 7.359123820899334 1.0000000165676552 0.45812717795560315 0.9992093035376522 0.007185676073526532 1.9532146735729107e-09 2.676707416851632e-10 0.006957501148351191 0.00231916698033402 1.0498612863675016e-10 9.978868078591756 -0.5418728386120522 GLFIIDPNGVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLFIIDPNGVIK 12 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 40068000.0 8879000.0 18121000.0 13068000.0 False True 11640454.98435831 15417417.435104758 11715848.717107499 1.0 1.3244686273708102 1.0064768716386514 23.472644113424142 -10.56862875189602 6.449100877680483 0.999726624711131 1.1654727495043191 0.26526982795903975 0.1298195906592562 0.0005111176671094502 3.418782631491296e-05 0.12590287990247476 0.04189909271956358 2.7000465279353738e-11 10.56862875189602 0.16574612479318807 GLFIIDPNGVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLFIIDPNGVIK 12 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 51793000.0 8879000.0 19210000.0 23704000.0 False True 12161806.245952839 18361238.68102499 18105603.399204113 1.0 1.509746028648925 1.4887265125794311 23.535854174947033 -10.001228257188599 4.773688546836814 0.9999915783348465 1.4992362706312252 0.9986722460196453 0.008581181558955576 5914829.272753587 0.4834365178516844 553.9757761360379 0.0029375666850627396 9.971758288030609e-11 10.001228257188599 0.4992446922963787 GLFILYK(ub)DGDVDSPVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLFILYKDGDVDSPVVR 17 1 Q01668-2;Q01668-3;A0A5F9Z6M3;A0A1B0GTN0;A0A1B0GUN6;A0A1B0GUB6;A0A1W2PQ56;A0A1B0GWE1;Q59GD8;Q01668-4;Q01668;A0A1B0GWF7 Q01668-2 CACNA1D Voltage-dependent L-type calcium channel subunit alpha-1D 1 49893700.0 1364500.0 3177700.0 45351500.0 True False 1788872.7138367973 2703599.546577582 40658961.82230638 1.0 1.5113426045718295 22.728817711742337 20.7706193062671 -6.912083910438233 0.8814084396671608 0.38557989751493293 25.596801939412014 0.9916849617845972 0.9232384557149225 0.1030560692885382 0.13140571193733055 0.7637457672843642 2.140047233182882 1.2243796128936426e-07 6.912083910438233 25.21122204189708 up GLFILYK(ub)DGDVDSPVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLFILYKDGDVDSPVVR 17 1 Q01668-2;Q01668-3;A0A5F9Z6M3;A0A1B0GTN0;A0A1B0GUN6;A0A1B0GUB6;A0A1W2PQ56;A0A1B0GWE1;Q59GD8;Q01668-4;Q01668;A0A1B0GWF7 Q01668-2 CACNA1D Voltage-dependent L-type calcium channel subunit alpha-1D 1 106437400.0 2517800.0 8289800.0 95629800.0 True False 2437873.81717404 11599960.370735895 70581486.54749472 1.0 4.758228374667258 28.9520671866898 21.21719202422061 -6.9343647277935085 0.7100572145219259 0.6848609826609384 34.52006711259876 0.9973285884545103 0.6401946571972034 0.09043411901019226 0.06703773037361661 0.599207865394233 2.1390308876231012 1.1631487872461903e-07 6.9343647277935085 33.83520612993782 GLFILYK(ub)DGDVDSPVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLFILYKDGDVDSPVVR 17 1 Q01668-2;Q01668-3;A0A5F9Z6M3;A0A1B0GTN0;A0A1B0GUN6;A0A1B0GUB6;A0A1W2PQ56;A0A1B0GWE1;Q59GD8;Q01668-4;Q01668;A0A1B0GWF7 Q01668-2 CACNA1D Voltage-dependent L-type calcium channel subunit alpha-1D 1 88399700.0 1364500.0 4337500.0 82697700.0 True False 1868992.5242260003 4145854.90780561 63166206.47259366 1.0 2.218229797105539 33.796928373885535 20.833829367789992 -6.9150433121490575 0.8606775088848906 0.17119791333222514 38.350909178260636 0.9926897486281756 1.2980294221052033 0.10117693277644889 0.12137400738642812 1.089960322689132 3.125101185792119 1.216064716575407e-07 6.9150433121490575 38.179711264928414 up GLFILYK(ub)DGDVDSPVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLFILYKDGDVDSPVVR 17 1 Q01668-2;Q01668-3;A0A5F9Z6M3;A0A1B0GTN0;A0A1B0GUN6;A0A1B0GUB6;A0A1W2PQ56;A0A1B0GWE1;Q59GD8;Q01668-4;Q01668;A0A1B0GWF7 Q01668-2 CACNA1D Voltage-dependent L-type calcium channel subunit alpha-1D 1 93472500.0 2517800.0 7375700.0 83579000.0 True False 2093662.257452222 7335965.64013817 101054982.47436632 1.0 3.503891620545 48.26708897992943 20.997597299654885 -6.918230855462915 0.8380040821209563 8.001635073923392e-15 55.19355870883408 0.993750206385344 1.716757857905584 0.09884901043393224 0.11076131669954133 1.4684380242808195 4.325293043526501 1.2071719749436695e-07 6.918230855462915 55.193558708834075 up GLFISISDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLFISISDR 9 0 A0A1W2PQT3;A0A1W2PPH1;A0A1W2PQY8;P23368;A0A1W2PQF8;A0A1W2PQH3;P23368-2;A0A1W2PQ37;A0A1W2PR68 A0A1W2PQT3 ME2 NAD-dependent malic enzyme, mitochondrial 0 16903500.0 7558900.0 4117300.0 5227300.0 False True 7318946.857032672 5761359.361435848 3858113.3143614125 1.0 0.7871842047739205 0.5271405011848401 22.80320463949418 -6.968440303771023 0.29305360738435393 1.0489902869507062 0.2572657179653119 0.9999675322779797 0.0011017861024181178 0.0768121024491885 0.010832082631343871 0.004469985542938905 0.023499858634847687 1.0753744065188624e-07 6.968440303771023 -0.7917245689853942 GLFISISDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLFISISDR 9 0 A0A1W2PQT3;A0A1W2PPH1;A0A1W2PQY8;P23368;A0A1W2PQF8;A0A1W2PQH3;P23368-2;A0A1W2PQ37;A0A1W2PR68 A0A1W2PQT3 ME2 NAD-dependent malic enzyme, mitochondrial 0 120916000.0 31718000.0 41408000.0 47790000.0 False True 48118524.896403775 34018418.87781933 38344285.552898854 1.0 0.7069713577267569 0.7968715922911549 25.520089080681007 -10.363919008664341 8.255266773052266 1.0000013917809838 0.751921475008956 0.9103382195990293 0.03670161707321577 9.401592931852044e-07 7.242002306535403e-08 0.03553638753473286 0.011845395975287209 4.325944978195983e-11 10.363919008664341 -0.2480799167720278 GLFISISDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLFISISDR 9 0 A0A1W2PQT3;A0A1W2PPH1;A0A1W2PQY8;P23368;A0A1W2PQF8;A0A1W2PQH3;P23368-2;A0A1W2PQ37;A0A1W2PR68 A0A1W2PQT3 ME2 NAD-dependent malic enzyme, mitochondrial 0 5809000.0 1106900.0 1675600.0 3026500.0 False True 1516150.8428477547 1601566.4515317772 2311703.032724061 1.0 1.0563371442142182 1.5247183640263902 20.531981864655382 -6.929385684427845 0.7518093349067654 0.9927130839470423 1.6193901524343202 0.9964163581184663 0.014080081995831512 0.09295758462987216 0.0792494501876413 0.012781187836118 0.04252429894210222 1.1765606397882061e-07 6.929385684427845 0.6266770684872779 GLFISISDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLFISISDR 9 0 A0A1W2PQT3;A0A1W2PPH1;A0A1W2PQY8;P23368;A0A1W2PQF8;A0A1W2PQH3;P23368-2;A0A1W2PQ37;A0A1W2PR68 A0A1W2PQT3 ME2 NAD-dependent malic enzyme, mitochondrial 0 14431700.0 7558900.0 2340100.0 4532700.0 False True 6285560.266047983 2327493.4168265206 5480466.613163125 1.0 0.3702921169014455 0.8719137803460983 22.583609914928456 -10.068678985650623 7.19832053387392 1.0000000749159066 0.6211029486238179 0.4320526633293652 0.20478618656091893 2.462045329567196e-07 3.201621597612962e-08 0.19828341093111768 0.06609445750698029 8.537309270419626e-11 10.068678985650623 -0.3788971262920887 GLFISISDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLFISISDR 9 0 A0A1W2PQT3;A0A1W2PPH1;A0A1W2PQY8;P23368;A0A1W2PQF8;A0A1W2PQH3;P23368-2;A0A1W2PQ37;A0A1W2PR68 A0A1W2PQT3 ME2 NAD-dependent malic enzyme, mitochondrial 0 114185000.0 31718000.0 44862000.0 37605000.0 False True 41059576.25525174 42365390.26313263 30761275.859884042 1.0 1.0318029099901844 0.7491863936601028 25.291215402773457 -6.878938580357819 1.0856455083398995 1.0194498617493304 0.7295563328872664 0.9728216088784184 0.02083801907877364 0.1285770971413342 0.27797159182611547 0.01479893268735972 0.03569474556476811 1.3214825102516502e-07 6.878938580357819 -0.289893528862064 GLFITIHDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLFITIHDR 9 0 P48163;P48163-2 P48163 ME1 NADP-dependent malic enzyme 0 9915500.0 3563300.0 3852800.0 2499400.0 False True 4671520.807046281 3277977.25809677 2240786.0639377465 1.0 0.7016938152458698 0.4796695030358979 22.155460863072463 -7.5335250126114115 0.1507873282017703 1.299980905595453 9.105308197908222e-14 0.9999834389882669 0.0008675361766577565 0.13291176021684983 0.014207817348779664 0.0422899341267255 0.07089379931093834 2.9273522695649063e-08 7.5335250126114115 -1.299980905595362 down GLFNLSIPVLLWGDLFTPALWDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLFNLSIPVLLWGDLFTPALWDR 23 0 Q9UJ37 Q9UJ37 ST6GALNAC2 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 0 41180000.0 11275000.0 12895000.0 17010000.0 False True 17104999.312912337 10593786.500905152 13647966.044252152 1.0 0.6193386101400217 0.797893399150825 24.02791471036599 -10.052517163445781 4.801699228622891 1.000008221253272 0.7086160046406046 0.780258773174727 0.07289468738438569 101004909.51202762 0.5426881702021852 9180.95809216112 0.02495379037419618 8.861002040265799e-11 10.052517163445781 -0.29139221661266734 GLFNLSIPVLLWGDLFTPALWDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLFNLSIPVLLWGDLFTPALWDR 23 0 Q9UJ37 Q9UJ37 ST6GALNAC2 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 0 29982300.0 11275000.0 12128000.0 6579300.0 False True 14595709.763477024 11453066.138631172 5381934.909318846 1.0 0.784687166587149 0.3687340318855963 23.79904103245844 -6.9607171524945155 0.4252058306155865 1.0173874569575887 0.1202081605267905 0.9997958791416357 0.003743446694921303 0.07944592506949057 0.02019204750108274 0.005400988864663972 0.034577185012880214 1.0946690707263393e-07 6.9607171524945155 -0.8971792964307982 down GLFSFFQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLFSFFQGR 9 0 Q9Y6X3;Q9Y6X3-3;Q9Y6X3-2 Q9Y6X3 MAU2 MAU2 chromatid cohesion factor homolog 0 6136700.0 1803200.0 1556400.0 2777100.0 False True 2364012.662213641 1324191.1867996834 2489752.3318242445 1.0 0.5601455558870493 1.0531890846527283 21.17280633227782 -6.671457429929428 1.9324812845373507 0.719592141830198 1.0511978141666802 0.2854325469388582 0.186778504657672 0.4577596748461355 3.297211053958445 0.07777706759532066 0.20738594588660828 2.1307994208438298e-07 6.671457429929428 0.3316056723364822 GLFSFFQGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLFSFFQGR 9 0 Q9Y6X3;Q9Y6X3-3;Q9Y6X3-2 Q9Y6X3 MAU2 MAU2 chromatid cohesion factor homolog 0 4059300.0 1580600.0 605200.0 1873500.0 False True 1530424.718176696 846859.5160763075 1382774.1462047554 1.0 0.5533493454583193 0.9035231395453105 20.545500649547233 -9.844747000554444 6.357358176076293 1.0000000122889479 0.7284362425017572 0.44502732126883304 0.1429578528014665 2.4931947879415838e-08 4.542188606667274e-09 0.13841835196509897 0.04613944859244038 1.429726607126093e-10 9.844747000554444 -0.27156376978719066 GLFSFFQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLFSFFQGR 9 0 Q9Y6X3;Q9Y6X3-3;Q9Y6X3-2 Q9Y6X3 MAU2 MAU2 chromatid cohesion factor homolog 0 7210400.0 1803200.0 1808100.0 3599100.0 False True 2469891.7696477277 1728212.1634128713 2749066.705791236 1.0 0.6997116977556309 1.1130312427347073 21.23601639380071 -6.711860305933857 1.7885985173241292 0.8157416299568007 1.112113582912735 0.4739309940244818 0.12650354199284938 0.37134413053838977 2.3168639028085822 0.0562607169338188 0.14260583019957415 1.9415102784582523e-07 6.711860305933857 0.29637195295593444 GLGATFILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLGATFILR 9 0 S4R3W9;A0A0A0MRF4;P49406 S4R3W9 MRPL19 39S ribosomal protein L19, mitochondrial 0 6899200.0 1330400.0 2067200.0 3501600.0 False True 1744167.2836119274 1758781.8178824903 3139288.021718977 1.0 1.0083790897856415 1.7998778277837828 20.734106985392867 -6.909214711894407 0.9010678160870305 0.9748805980413857 1.9004653405217962 0.9906217294134083 0.03632587962702024 0.1049397330710081 0.14160194536112988 0.02962544392814415 0.08134126155325118 1.2324953462371792e-07 6.909214711894407 0.9255847424804104 GLGATFILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLGATFILR 9 0 S4R3W9;A0A0A0MRF4;P49406 S4R3W9 MRPL19 39S ribosomal protein L19, mitochondrial 0 42979400.0 7750400.0 10751000.0 24478000.0 False True 11757923.430137094 8832400.052053612 19639912.57091147 1.0 0.7511870701092521 1.6703555425928194 23.48712995214285 -6.834603024594593 1.3070840126962533 0.8674088062875406 1.6975218023471943 0.9147908304425636 0.11331217954598034 0.17520060351548308 0.583731496980503 0.06802850935114296 0.15658137094564023 1.4635143172636753e-07 6.834603024594593 0.8301129960596537 GLGATFILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLGATFILR 9 0 S4R3W9;A0A0A0MRF4;P49406 S4R3W9 MRPL19 39S ribosomal protein L19, mitochondrial 0 7114800.0 1330400.0 2210000.0 3574400.0 False True 1822284.83270815 2112354.892507298 2730200.3370787688 1.0 1.1591793196061817 1.4982291945114528 20.797317046915758 -6.958794796162568 0.4520994185904361 0.9892979397154978 1.6815987447073049 0.9997228528898746 0.0034589391036846393 0.0801344935156974 0.022743551578210904 0.004546152094934213 0.028036516742331128 1.0995252416180779e-07 6.958794796162568 0.692300804991807 GLGATFILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLGATFILR 9 0 S4R3W9;A0A0A0MRF4;P49406 S4R3W9 MRPL19 39S ribosomal protein L19, mitochondrial 0 4419200.0 2685100.0 0.0 1734100.0 False True 2232779.62009888 0.0 2096692.2924275114 1.0 0.0 0.9390502643223957 21.090409430569355 -10.278655048597582 10.676012359131958 1.0000000105578917 0.4695251321611998 0.29848747586825974 0.38336566506925673 9.632426800895175e-08 6.735242822580796e-09 0.37119221461141033 0.12373073636008017 5.2643523733344174e-11 10.278655048597582 -0.5304748783966919 GLGATFILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLGATFILR 9 0 S4R3W9;A0A0A0MRF4;P49406 S4R3W9 MRPL19 39S ribosomal protein L19, mitochondrial 0 35813600.0 7750400.0 18626000.0 9437200.0 False True 10033045.58322415 17589446.726430118 7719726.433849148 1.0 1.7531512819836803 0.76943001701866 23.2582562742353 -6.702103050401744 1.823185030555361 1.4667012228063696 0.7722187326740486 0.4276644693997236 0.31779273536299274 0.3911555164283065 2.5291706759121024 0.13897612353590022 0.35650949131732246 1.985623708056887e-07 6.702103050401744 -0.694482490132321 GLGLDESGLAK(ub)QAASGLVGQENAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLGLDESGLAKQAASGLVGQENAR 24 1 Q9Y265;Q9Y265-2 Q9Y265 RUVBL1 RuvB-like 1 1 13027500.0 2897500.0 6155500.0 3974500.0 True False 2409399.631014304 6122339.099728907 4805549.5739883175 1.0 2.5410226767369175 1.9945008342037838 21.2002422729321 -9.832293834391834 5.977619824093328 0.9999998673617194 2.267761755471973 0.8776701738213046 0.22311660792108276 3.948482319810177e-07 7.700970977761047e-08 0.21603174921574508 0.07201057556087556 1.4713167040738576e-10 9.832293834391834 1.2677618881102537 GLGLPDDASPGHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLGLPDDASPGHLR 14 0 Q6T4P5-4;Q6T4P5;Q6T4P5-2;Q6T4P5-3 Q6T4P5-4 LPPR3 Lipid phosphate phosphatase-related protein type 3 0 12521700.0 3350200.0 2519200.0 6652300.0 False True 4392144.643382948 2143345.1797646866 5963983.809367474 1.0 0.4879951262519953 1.3578750914664444 22.0664941357017 -6.747212702326043 1.660229731884361 0.697926448096254 1.3592347410076577 0.6368446922236772 0.2151248139050882 0.304940846044147 1.6528588416646326 0.10239900416007543 0.24932224285282478 1.7897290923129938e-07 6.747212702326043 0.6613082929114037 GLGLPDDASPGHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLGLPDDASPGHLR 14 0 Q6T4P5-4;Q6T4P5;Q6T4P5-2;Q6T4P5-3 Q6T4P5-4 LPPR3 Lipid phosphate phosphatase-related protein type 3 0 17598000.0 3672800.0 3691200.0 10234000.0 False True 3556208.9743890753 5165115.409353704 7553408.386580978 1.0 1.4524217914502688 2.1240057715895575 21.761908673428994 -6.965430156309552 0.3505912745270082 0.9355394242569014 2.663570374233524 0.9999217399442184 0.004085047714938578 0.07781529942741963 0.014346949469437148 0.00920476562951762 0.057701933175090245 1.0828538468072196e-07 6.965430156309552 1.7280309499766227 GLGLPDDASPGHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLGLPDDASPGHLR 14 0 Q6T4P5-4;Q6T4P5;Q6T4P5-2;Q6T4P5-3 Q6T4P5-4 LPPR3 Lipid phosphate phosphatase-related protein type 3 0 20771800.0 6194000.0 4798900.0 9778900.0 False True 9396750.842055773 3942498.801023169 7846096.128755877 1.0 0.41955978904732233 0.8349796925167112 23.163730565010546 -9.858287778705748 5.841200282272461 1.0000000798775817 0.6272697407814403 0.5176957080461966 0.16959446541816764 59883389.04355472 101066159.05317003 43.21555466103007 0.05805669543792395 1.3858372203662233e-10 9.858287778705748 -0.3727303390961414 GLGLPDDASPGHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLGLPDDASPGHLR 14 0 Q6T4P5-4;Q6T4P5;Q6T4P5-2;Q6T4P5-3 Q6T4P5-4 LPPR3 Lipid phosphate phosphatase-related protein type 3 0 13393000.0 3350200.0 2065500.0 7977300.0 False True 4588859.475750781 1974239.3803048972 6093226.037650639 1.0 0.43022441430980907 1.3278301656107545 22.12970419722459 -6.735184874907386 1.7042006131885645 0.659105276916807 1.3278336654135343 0.5831511806910036 0.2394393577083674 0.3266189115832024 1.8605865448988566 0.11123412633817394 0.2744277524038392 1.8399885696182546e-07 6.735184874907386 0.6687283884967273 GLGLPDDASPGHLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLGLPDDASPGHLR 14 0 Q6T4P5-4;Q6T4P5;Q6T4P5-2;Q6T4P5-3 Q6T4P5-4 LPPR3 Lipid phosphate phosphatase-related protein type 3 0 23161600.0 3672800.0 3959800.0 15529000.0 False True 3054095.932627898 3938467.7714412427 18776042.10201649 1.0 1.2895691092625197 6.147823289185496 21.54231394886327 -6.919117542552288 0.8312555790416869 0.8893589135177977 6.9155508844545395 0.9939320752296105 0.1839469495451877 0.09869361494246015 0.10832855617396714 0.15775307124079155 0.4686246364170585 1.2047098394432809e-07 6.919117542552288 6.0261919709367415 up GLGLSPDLVVCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLGLSPDLVVCR 12 0 A0A3B3IRI2;P17812;B4E1E0;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 15961100.0 3786000.0 5994700.0 6180400.0 False True 5185786.512802951 5729834.332178054 4720716.8093334865 1.0 1.1049113414198461 0.9103183861654784 22.306131384219555 -6.760298991865868 1.6116051665096747 1.060916616484275 0.9096034164207463 0.692085902745757 0.04412748611723851 0.2824162123193654 1.4457921170201469 0.021604329918668945 0.05189788299659422 1.7366048441845354e-07 6.760298991865868 -0.15131320006352866 GLGMAYFPAISLSFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLGMAYFPAISLSFK 15 0 C9JS59;C9J266;Q5XPI4;Q5XPI4-2 C9JS59 RNF123 E3 ubiquitin-protein ligase RNF123 0 20070200.0 5396400.0 6089000.0 8584800.0 False True 8186733.329685149 5002370.376425852 6888010.5171484845 1.0 0.6110337511895281 0.8413625117325506 22.964856471838694 -10.277563704259657 5.589903309321458 1.0000250661345926 0.7261981314610335 0.6532772569117056 0.09403132273637017 2.9376862254492976e-05 3.7965595385407833e-06 0.09105376180715574 0.030348478914981696 5.2775978693437304e-11 10.277563704259657 -0.2738269346735591 GLGMAYFPAISLSFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLGMAYFPAISLSFK 15 0 C9JS59;C9J266;Q5XPI4;Q5XPI4-2 C9JS59 RNF123 E3 ubiquitin-protein ligase RNF123 0 13236600.0 5396400.0 4989800.0 2850400.0 False True 6985746.178946992 4712113.243613285 2331656.4475738183 1.0 0.6745325585710835 0.3337734277550411 22.735982793931143 -7.235276135989809 0.2805513373687701 1.0875251669400725 7.048407623075046e-12 0.9999290927729797 0.002290489609824247 0.0954120869839427 0.016152582821166273 0.011605637475227795 0.04256492946627787 5.8173321869314566e-08 7.235276135989809 -1.0875251669330241 down GLGMTLSYLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLGMTLSYLFR 11 0 E9PKH6;E9PPW7;O00217;E9PN51;F8W9K7 E9PKH6 NDUFS8 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial 0 64698800.0 24544800.0 15536000.0 24618000.0 False True 37236256.065239035 12763479.416677956 19752241.509547267 1.0 0.3427702128354676 0.5304572370256759 25.15020468803078 -10.37299401097391 5.054965813690823 1.0003813400535437 0.436613724930549 0.923158879540045 0.07662290676813487 0.0003295157845456264 4.087238032493498e-05 0.07423854459811631 0.02472993682088247 4.2364880822893015e-11 10.37299401097391 -0.5637676151229947 GLGMTLSYLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLGMTLSYLFR 11 0 E9PKH6;E9PPW7;O00217;E9PN51;F8W9K7 E9PKH6 NDUFS8 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial 0 62935500.0 24544800.0 20175200.0 18215500.0 False True 31773727.450340606 19052432.384573843 14900465.906813389 1.0 0.5996284954086999 0.4689555523537941 24.92133101012323 -13.999999999999998 0.1565590782530633 2.9581174365118157 0.33549262533787044 0.9995458445151221 0.004814677618029967 11.988516961359936 0.12491409498778569 7.131157302645172 0.12113595875158019 1.0000000000000041e-14 13.999999999999998 -2.6226248111739454 GLGTDEDSLIEIICSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLGTDEDSLIEIICSR 16 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YMM1;H0YNA0;H0YN52;H0YLE2 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 11715600.0 5674400.0 3648400.0 2392800.0 False True 5494269.278009529 5105225.146154657 1766053.897538688 1.0 0.9291909238209352 0.32143562832044087 22.38949618897144 -6.928811954241537 0.7564876142178224 1.0096612684064574 0.20036225174519165 0.9962993934527354 0.018527388673855203 0.09325964678507341 0.08073896009266067 0.016761496757229828 0.05535509848563591 1.1781159771387184e-07 6.928811954241537 -0.8092990166612658 down GLGTSTAK(ub)EAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLGTSTAKEAK 11 1 Q02880;Q02880-2;E9PCY5 Q02880 TOP2B DNA topoisomerase 2-beta;DNA topoisomerase 2 1 2730550.0 949560.0 778390.0 1002600.0 True False 1244882.3555521194 662257.2461404554 898860.5696183017 1.0 0.5319838000649763 0.7220445896830523 20.247577979825554 -10.181678901938938 5.3781296846716335 1.0000148134192668 0.6270141948739342 0.8370001351271861 0.07759199244607284 1.3782372244161942e-05 2.096933760118741e-06 0.0751311057067553 0.025042707878516972 6.581442601636923e-11 10.181678901938938 -0.3730006185453326 GLGTSTSK(ub)EAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLGTSTSKEAK 11 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 1291750.0 269740.0 561640.0 460370.0 True False 224300.7615081273 558614.3338431888 556631.2384896209 1.0 2.4904700728042246 2.4816288395411976 17.77507499286427 -10.075640581966205 4.771385027911259 0.9999422491241059 2.486049456194736 0.9999734533309734 0.0036094184409576264 1253203.7502742223 0.11049853464372286 795.1338791614917 0.0012355999258380345 8.401550032740004e-11 10.075640581966205 1.4861072070706303 GLGVEIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLGVEIAK 8 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 25139300.0 5011500.0 9324800.0 10803000.0 False True 6570125.031435032 7933576.1877857065 9685209.189693304 1.0 1.2075228629329253 1.4741285962373658 22.647489395049085 -6.967703880888845 0.30813639685143324 0.9580127202624045 1.7320905579208237 0.9999585271822483 0.0012497373714765428 0.07705499858231848 0.011683297224746453 0.004254242888412303 0.02371264013347719 1.0771994403641523e-07 6.967703880888845 0.7740778376584192 GLGVEIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLGVEIAK 8 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 13733300.0 3446500.0 2135200.0 8151600.0 False True 3337092.7440187205 2987796.494920902 6016451.417241886 1.0 0.8953291754555267 1.8029020703801377 21.670160351582066 -6.878192397857953 1.0898799019051992 0.9365614900044182 1.8650203161598833 0.9721957121583604 0.06760241544164045 0.12924100079365244 0.28209159008953066 0.04785779688796671 0.11521468511126251 1.3237549653586927e-07 6.878192397857953 0.928458826155465 GLGVEIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLGVEIAK 8 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 37262100.0 3362000.0 28526000.0 5374100.0 False True 5100399.79512294 23435312.425344694 4311906.779448299 1.0 4.594799107268768 0.8454056451753826 22.28217890657205 -6.655740852045634 1.9882639956710257 3.3219862436665086 0.8611904151947103 0.2176314412006497 1.5321523731841358 0.4945708792110441 3.753895609596894 0.6236060980071676 1.6975114888168261 2.2093226651740864e-07 6.655740852045634 -2.4607958284717983 GLGVEIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLGVEIAK 8 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 25289700.0 5011500.0 9583200.0 10695000.0 False True 6864386.980695195 9159782.536595447 8169061.270439073 1.0 1.3343919220107525 1.190064210163709 22.710699456571977 -10.091806002606464 4.1109340311732145 0.9999523648869941 1.262228066142176 0.8148651684115417 0.058921541899328016 41305177.81964196 67303259.75839943 25596.711569887706 0.021563072876696333 8.094573994150746e-11 10.091806002606464 0.26227570125518196 GLGVEIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLGVEIAK 8 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 7441100.0 3446500.0 2151800.0 1842800.0 False True 2865917.455838069 2140207.8263011393 2228120.9598554946 1.0 0.7467792981760135 0.7774546874393261 21.450565627016342 -9.919742340534437 6.688307286194619 1.0000000141666858 0.7621169929159206 0.9876822347519162 0.012523175226074955 2.659333006256988e-09 4.0522413035287863e-10 0.012125512995786451 0.004041837424350053 1.2029779291120852e-10 9.919742340534437 -0.23788302125076521 GLGVEIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLGVEIAK 8 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 12373600.0 3362000.0 5265200.0 3746400.0 False True 4352175.274927684 4972186.9915172225 3064593.641310185 1.0 1.1424601900023066 0.7041521647726163 22.0533052286645 -6.819190578075536 1.375422154051949 1.0768480408408483 0.6947522298233139 0.882502096533678 0.06257591537048096 0.19453475104959295 0.7233621222116501 0.03575425006926745 0.08242412563415312 1.5163847980693016e-07 6.819190578075536 -0.3820958110175344 GLGVHHSGILPILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLGVHHSGILPILK 14 0 Q15477 Q15477 SKIV2L Helicase SKI2W 0 7597300.0 2343300.0 2643000.0 2611000.0 False True 3072088.992549477 2248674.70233331 2340838.7664805343 1.0 0.7319692586337387 0.7619697125173155 21.550788578107916 -9.745323277727525 5.936736684308551 1.0000000090050978 0.7469694857265329 0.9895668285858851 0.01224763401560352 1.4506134925590808e-09 2.976529473230115e-10 0.011858720994664226 0.003952906880415664 1.7975323797809935e-10 9.745323277727525 -0.2530305232785649 GLGVHHSGILPILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLGVHHSGILPILK 14 0 Q15477 Q15477 SKIV2L Helicase SKI2W 0 9635500.0 2343300.0 2026600.0 5265600.0 False True 3209681.335301415 1937058.110929998 4021973.7284360877 1.0 0.6035048057965832 1.2530757132182382 21.613998639630807 -6.741479717843948 1.6810655825088292 0.7644993594322551 1.25359909028007 0.6116944491204517 0.1665857803391991 0.31512668234056174 1.7491033707673593 0.07837318254539541 0.19202510899865474 1.8135113673951454e-07 6.741479717843948 0.4890997308478149 GLGVHHSGILPILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLGVHHSGILPILK 14 0 Q15477 Q15477 SKIV2L Helicase SKI2W 0 6831000.0 2467400.0 2108400.0 2255200.0 False True 2051752.4243536456 2097041.6307153672 2726751.8931333367 1.0 1.0220734265129423 1.3289868020954492 20.968425227313105 -6.921377207258684 0.8144318513108608 0.9935586295998983 1.380084530654454 0.9945553790418843 0.011079495525818354 0.09736806952400764 0.10145969326810919 0.009616435733357909 0.02919691962281678 1.1984579281670876e-07 6.921377207258684 0.38652590105455575 GLGVHLSFVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLGVHLSFVR 10 0 F8VWB3;E5RGL6;E5RHC5;Q8N6T3-3;Q8N6T3;Q8N6T3-2;E5RIU2 F8VWB3 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 0 71864900.0 20846000.0 18122000.0 32896900.0 False True 31624906.046737935 14887987.512167726 26394813.295776546 1.0 0.4707678021292778 0.8346210817754867 24.914557857975588 -10.152209523082627 5.6435527104825844 1.000005703763236 0.6526944419523593 0.5484947185449526 0.14854247939533594 1.0660559515292421e-05 1.601100927296798e-06 0.14382800036052157 0.04794187907519314 7.043531755085811e-11 10.152209523082627 -0.3473112618108767 GLGVHLSFVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLGVHLSFVR 10 0 F8VWB3;E5RGL6;E5RHC5;Q8N6T3-3;Q8N6T3;Q8N6T3-2;E5RIU2 F8VWB3 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 0 4964500.0 2359800.0 1340500.0 1264200.0 False True 1962278.2568654197 1333278.4604315825 1528538.374999631 1.0 0.6794543310903249 0.7789610722392384 20.90409820381497 -10.499844678688527 8.92767358735442 1.000009277113216 0.7292077016647818 0.9080400616144455 0.040623456963674046 7.501441733759762e-06 4.2026371359124774e-07 0.03933483915031121 0.013111164357140269 3.1634088211095225e-11 10.499844678688527 -0.2708015754484343 GLGVHLSFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLGVHLSFVR 10 0 F8VWB3;E5RGL6;E5RHC5;Q8N6T3-3;Q8N6T3;Q8N6T3-2;E5RIU2 F8VWB3 ARFGAP1 ADP-ribosylation factor GTPase-activating protein 1 0 61095000.0 20846000.0 23296000.0 16953000.0 False True 26985557.93609239 21999557.12117016 13867727.952469459 1.0 0.8152344736866233 0.5138944314329621 24.685684180068037 -6.9638293508535964 0.3776076100541679 1.0212640733697176 0.29724906282032126 0.9998869382321078 0.0021302697631300485 0.07836052750445895 0.016274813710937995 0.003931857416066515 0.025492576234570435 1.0868526012608705e-07 6.9638293508535964 -0.7240150105493963 GLGVSALCFK(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLGVSALCFKSR 12 1 E9PDU5;A0A087X295;Q9NNW5 E9PDU5 WDR6 WD repeat-containing protein 6 1 19089800.0 5174000.0 12616200.0 1299600.0 True False 6783164.10508728 10733912.137562439 1165129.858643473 1.0 1.5824343877383347 0.17176790073081696 22.6935269656777 -6.794556754458862 1.4779205282275178 1.3235907603214665 0.15477829305241042 0.8158415636347328 0.24838824801593756 0.22859544772008292 0.9862061046852941 0.1322527934461158 0.30866180301021356 1.604882515182176e-07 6.794556754458862 -1.168812467269056 down GLGVSALCFK(ub)SR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLGVSALCFKSR 12 1 E9PDU5;A0A087X295;Q9NNW5 E9PDU5 WDR6 WD repeat-containing protein 6 1 21452600.0 10391000.0 4011200.0 7050400.0 True False 15763906.683855614 3295370.0203513554 5656885.349699898 1.0 0.20904526310893878 0.3588504717230608 23.910121778636434 -9.972567895269869 6.912667192774065 1.0000000565780753 0.2839478676300279 0.9682167431065528 0.06115772031930443 5.3354054319488784e-08 7.914129585317751e-09 0.059215713366414194 0.01973856935738876 1.0652023226321584e-10 9.972567895269869 -0.7160521889480475 GLGVSALCFK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLGVSALCFKSR 12 1 E9PDU5;A0A087X295;Q9NNW5 E9PDU5 WDR6 WD repeat-containing protein 6 1 6509000.0 3155200.0 1214600.0 2139200.0 True False 2623688.599059993 1208056.7087207758 2586496.829456739 1.0 0.460442107784283 0.9858246250654217 21.323165068528816 -10.88311303891429 10.64071099643423 1.015794658776154 0.7231333664248526 0.2702214575755737 0.21448651451962583 0.07389822963039562 0.000811761878907408 0.19095748353486192 0.06922522489338212 1.3088412112204877e-11 10.88311303891429 -0.29266129235130134 GLGVSALCFK(ub)SR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLGVSALCFKSR 12 1 E9PDU5;A0A087X295;Q9NNW5 E9PDU5 WDR6 WD repeat-containing protein 6 1 21625000.0 10391000.0 4619200.0 6614800.0 True False 13451354.337231902 4362137.459396861 5410974.273579597 1.0 0.32428983357630636 0.40226241446949335 23.681248100728883 -10.534074722335976 6.309054530644741 1.0007318181080354 0.3632761240270868 0.9888779328800045 0.031832172852698876 0.0003280084972549143 2.4223529241033663e-05 0.030853289293617372 0.010273789611008215 2.923649307439059e-11 10.534074722335976 -0.6374556940809486 GLGWVQFSSEEGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLGWVQFSSEEGLR 14 0 Q9GZT3-2;Q9GZT3;H0YJW7;A0A087WUN7;H0YJ40;G3V4X6;G3V2S9 Q9GZT3-2 SLIRP SRA stem-loop-interacting RNA-binding protein, mitochondrial 0 10721500.0 3693100.0 1923400.0 5105000.0 False True 3575864.562000734 2691423.650398497 3767847.3532827683 1.0 0.7526637555010242 1.0536884962932205 21.769860663946577 -6.688401867198762 1.872207408875648 0.8447013415689024 1.0526246826628955 0.3628730744936549 0.1046404925448796 0.42013064789619997 2.8539277512820096 0.0447344624443874 0.11672201756408239 2.0492650477838735e-07 6.688401867198762 0.20792334109399313 GLGWVQFSSEEGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLGWVQFSSEEGLR 14 0 Q9GZT3-2;Q9GZT3;H0YJW7;A0A087WUN7;H0YJ40;G3V4X6;G3V2S9 Q9GZT3-2 SLIRP SRA stem-loop-interacting RNA-binding protein, mitochondrial 0 8393300.0 3693100.0 2059600.0 2640600.0 False True 3070976.28207038 2048504.526001408 3192737.2512450726 1.0 0.6670531902058047 1.0396489448276052 21.550265939380854 -6.671114373125754 1.9336156651985048 0.7876802042000023 1.0381430391777244 0.2838754250053742 0.14139330509617004 0.4585849703719717 3.306685336668366 0.058849029982997104 0.15699069329302343 2.1324832415095338e-07 6.671114373125754 0.25046283497772215 GLIAAICAGPTALLAHEIGFGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLIAAICAGPTALLAHEIGFGSK 23 0 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 1481966000.0 498997000.0 522195000.0 460774000.0 False True 757014930.5672115 429005222.3218425 369701816.9355813 1.0 0.5667064214973938 0.48836793305856385 29.49574651379188 -13.999999999999996 0.24055928007337546 3.87578073826056 0.453914158996334 0.9995258913616812 0.004899276260080212 13.643235712515212 0.1552315749629046 18.853866311269055 0.03815380399193419 1.0000000000000082e-14 13.999999999999996 -3.421866579264226 GLIAAICAGPTALLAHEIGFGSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLIAAICAGPTALLAHEIGFGSK 23 0 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 1598810000.0 775480000.0 153630000.0 669700000.0 False True 644845979.5889463 152802364.69683245 809731173.6570565 1.0 0.23695947487217878 1.2556970180278015 29.264379375421303 -6.706208292269358 1.8084534605931801 0.5291094356200292 1.2530786693167721 0.44724840442193003 0.32173635480062307 0.3827222490946631 2.4374627746069875 0.14169761189747915 0.36167951915820123 1.966942696732995e-07 6.706208292269358 0.7239692336967429 GLIAAICAGPTALLAHEIGFGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLIAAICAGPTALLAHEIGFGSK 23 0 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 988674400.0 498997000.0 281508000.0 208169400.0 False True 645961453.2013958 265841832.33457989 170284705.19841897 1.0 0.411544421136994 0.263614344717452 29.266872835884328 -13.999999999999854 0.19389735361914592 4.198114774718131 0.16155119082323977 0.9994877340804035 0.007198614684844435 12.416798478022027 0.13964014557806279 15.023865979639764 0.09866755097786672 1.0000000000003354e-14 13.999999999999854 -4.036563583894891 GLIK(ub)LVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLIKLVSK 8 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 4794120.0 899620.0 1626800.0 2267700.0 True False 1179410.5319324732 1384087.781216734 2033060.1573144041 1.0 1.1735419887669611 1.723793456366054 20.169634551671855 -6.95020016333966 0.556641229275716 0.9926729114145187 1.930808794876969 0.9992169016973333 0.008634138949988358 0.08340545458720214 0.035630414618647833 0.009293306579640946 0.04570816585021074 1.1215014428662058e-07 6.95020016333966 0.9381358834624502 GLIK(ub)LVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLIKLVSK 8 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 11727300.0 1403500.0 2928100.0 7395700.0 True False 1358946.6607370593 4097305.599839783 5458544.303755806 1.0 3.0150599123717665 4.01674654455917 20.374057400116516 -8.944176975645979 0.2682711856566119 4.110204215494341e-18 4.6171054823858615 0.9989872289809804 0.039924231543437425 0.42711211418228273 0.08968167934003786 0.7993487651395158 0.3849567349691584 1.1371637954588498e-09 8.944176975645979 4.6171054823858615 GLIK(ub)LVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLIKLVSK 8 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 4784440.0 899620.0 931520.0 2953300.0 True False 1232233.8253163758 890362.3662752939 2255791.3651227388 1.0 0.7225595889211153 1.8306520392292953 20.232844613194747 -6.840387643563747 1.280515999369592 0.8524101211950114 1.8673956884606229 0.9251282193770303 0.12882205202901584 0.1683487718304113 0.536040633517295 0.07887768873350043 0.18174603253330568 1.4441501724253803e-07 6.840387643563747 1.0149855672656116 GLIK(ub)LVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLIKLVSK 8 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 6026300.0 1403500.0 3064100.0 1558700.0 True False 1167072.4355922618 3047593.0851237685 1884616.9633854774 1.0 2.6113144241789814 1.6148243295876306 20.154462675550793 -10.33419869221785 7.316818149143225 0.9999850385011003 2.1130693768833058 0.6245619481538192 0.40681537758109215 9.928856967928011e-05 9.035383274386449e-06 0.3939025647424105 0.1312990985293877 4.632349386058155e-11 10.33419869221785 1.1130843383822056 GLINLGNTCFMNCIVQALTHTPLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLINLGNTCFMNCIVQALTHTPLLR 25 0 Q9UPT9;Q9UPT9-2;K7ESK0;K7ERX6;J3QS30 Q9UPT9 USP22 Ubiquitin carboxyl-terminal hydrolase 22 0 1743920000.0 814440000.0 479110000.0 450370000.0 False True 1235565023.5395396 393609077.1964839 361354172.09581625 1.0 0.318566056579448 0.2924606679627756 30.202523790731117 GLINLGNTCFMNCIVQALTHTPLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLINLGNTCFMNCIVQALTHTPLLR 25 0 Q9UPT9;Q9UPT9-2;K7ESK0;K7ERX6;J3QS30 Q9UPT9 USP22 Ubiquitin carboxyl-terminal hydrolase 22 0 1254780000.0 814440000.0 101850000.0 338490000.0 False True 1054308635.0125244 96181957.96665446 276888293.2006949 1.0 0.09122751609210893 0.262625462796675 29.973650112823567 -9.944816467400118 6.479508042352646 1.0000001197756234 0.17692648944437572 0.9685011015979252 0.06997291873123952 1.211098708600469e-07 1.9787802075960368e-08 0.06775099732832862 0.022583662410955566 1.1354905719596616e-10 9.944816467400118 -0.8230736303312477 GLIPVFALGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLIPVFALGR 10 0 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 28870100.0 6424700.0 8087400.0 14358000.0 False True 8422843.916883295 6880791.444438284 12872371.891661245 1.0 0.8169202127378828 1.5282690761797244 23.00587600119626 -6.8383947987441855 1.2897275093278613 0.9025730351096772 1.5509467280587153 0.9216747912129298 0.08440464707149907 0.17068219949489524 0.5521792158392724 0.0513281743718697 0.11821085645807146 1.4507921641565388e-07 6.8383947987441855 0.648373692949038 GLIPVFALGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLIPVFALGR 10 0 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 20812200.0 7497600.0 3810800.0 9503800.0 False True 7259592.791978741 5332472.313059467 7014469.6721114125 1.0 0.7345415184928024 0.9662345909899837 22.791457195579763 -10.202337013618815 6.964818861490364 1.0000004162823632 0.8503880549387101 0.3573108187043609 0.09458830075929418 6.113777589299363e-07 7.005059205427315e-08 0.09158498291326311 0.0305282427989004 6.275711729880304e-11 10.202337013618815 -0.1496123613436532 GLIPVFALGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLIPVFALGR 10 0 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 23307000.0 6424700.0 7032100.0 9850200.0 False True 8800085.210989203 6721398.569955015 7523785.631236933 1.0 0.763787896231004 0.854967361207085 23.06908606271915 -10.311747874987766 4.956437789375065 1.0000739421790608 0.8093776287544772 0.8535364116388379 0.03722386070216596 3.0426760199118688e-05 4.225083476051469e-06 0.03605580271483744 0.012013949381714045 4.878116017199546e-11 10.311747874987766 -0.1906963134245836 GLIPVFALGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLIPVFALGR 10 0 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 14434900.0 7497600.0 2821500.0 4115800.0 False True 6234586.599997528 2806300.0194760966 4976394.750690926 1.0 0.45011805906701324 0.7981916155744632 22.57186247101404 -10.099854389757418 5.244112041259069 1.0000071539274498 0.624154837320322 0.6085470572445824 0.1421004344013363 1.1885625781241185e-05 2.040092205146466e-06 0.137590771092653 0.04586271799355278 7.945946017253982e-11 10.099854389757418 -0.3758523166071278 GLIVYQLENQPSEFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLIVYQLENQPSEFR 15 0 P78406;E9PQ57;E9PPG9 P78406 RAE1 mRNA export factor 0 6079200.0 1251000.0 2780000.0 2048200.0 False True 1640073.114701232 2365234.836355124 1836271.9117217294 1.0 1.4421520694130718 1.119628079542197 20.64532870115878 -10.320654945742481 5.251315809836067 0.9999239531963737 1.2808900744776557 0.5028134269896626 0.13166986749844367 0.00011726124361012915 1.5169680289787657e-05 0.12752320795340666 0.04249626700155668 4.7790882944491156e-11 10.320654945742481 0.28096612128128196 GLIVYQLENQPSEFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLIVYQLENQPSEFR 15 0 P78406;E9PQ57;E9PPG9 P78406 RAE1 mRNA export factor 0 3549600.0 1251000.0 2298600.0 0.0 False True 1713528.5070038284 2197040.251546282 0.0 1.0 1.2821731547308148 0.0 20.70853876268167 -6.888205803872773 1.3227010762836229 1.14702754509915 2.0232242963361637e-20 0.9376500613729916 0.1373623147447646 0.1427180064196013 0.5016890291972224 0.08447723431619387 0.17055886749567853 1.293582692013036e-07 6.888205803872773 -1.14702754509915 down GLK(ub)AGVLSQADYLNLVQCETLEDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLKAGVLSQADYLNLVQCETLEDLK 25 1 F5GYQ1;P61421;H3BQB4;H3BSG7 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 40583000.0 11516000.0 11453000.0 17614000.0 True False 17470613.93237236 9409122.667302577 14132585.179509556 1.0 0.5385685187552478 0.8089346621827886 24.05842697089932 -10.237660439701578 5.7121327209234805 1.00001441994674 0.6737515904690126 0.6600340553129588 0.11037651585362317 2.027019073806099e-05 2.7053817070876986e-06 0.10687632155518806 0.035623867309453584 5.78548218073677e-11 10.237660439701578 -0.32626282947772745 GLK(ub)AGVLSQADYLNLVQCETLEDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLKAGVLSQADYLNLVQCETLEDLK 25 1 F5GYQ1;P61421;H3BQB4;H3BSG7 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 40745000.0 11516000.0 9070000.0 20159000.0 True False 14907689.014297234 8565246.52682923 16490268.84880738 1.0 0.5745522675321924 1.1061586294825692 23.82955329299177 -6.693600055388017 1.8535550320262093 0.7341706035817469 1.1044062271558373 0.38727219443661887 0.17980626636058986 0.40902368095116204 2.727262791036707 0.07752248640398032 0.20096777746900826 2.0248830482858245e-07 6.693600055388017 0.37023562357409034 GLK(ub)EGIPALDNFLDKL ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLKEGIPALDNFLDKL 16 2 P13639 P13639 EEF2 Elongation factor 2 1 17303500.0 5085400.0 2757200.0 9460900.0 True False 7714923.592539626 2265156.117898076 7590948.968140224 1.0 0.2936070708579012 0.9839305441055455 22.879220437952974 -10.820298442934561 10.746504966048144 1.0042327397751598 0.6387688075777307 0.26744937493298226 0.28182337782042705 0.028601636798236636 0.0004782713891632757 0.273077260747375 0.09095810407253618 1.5125215011931315e-11 10.820298442934561 -0.3654639321974291 GLK(ub)MAVTFIGNSTAIQELFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLKMAVTFIGNSTAIQELFK 20 1 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 1 4446260.0 1418200.0 2381000.0 647060.0 True False 1179296.1369126784 2368173.0804085066 782357.2543325907 1.0 2.008124173634819 0.6634103426987829 20.169494613009647 -6.706077100628536 1.8089986625465748 1.6222569444571004 0.6669041932309364 0.4464252928569614 0.4250916536032072 0.3830773499344911 2.4411280033860687 0.18716785426272178 0.4778038479333263 1.9675369603715854e-07 6.706077100628536 -0.955352751226164 GLK(ub)YLHQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLKYLHQEK 9 1 Q96KB5;Q96KB5-2;E5RFX4 Q96KB5 PBK Lymphokine-activated killer T-cell-originated protein kinase 1 5231630.0 583510.0 969620.0 3678500.0 True False 564986.7944472262 1356794.3225015013 2714990.4973654565 1.0 2.4014620090881356 4.805405230792622 19.10785762195022 -6.9629331706779 0.39191522426149034 0.8554727841592586 6.438035349826992 0.9998639877160385 0.018326534479209348 0.07866957180674401 0.017378387622337118 0.03100671653894675 0.20205279722282482 1.0890976710080117e-07 6.9629331706779 5.582562565667734 GLK(ub)YLHQEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLKYLHQEK 9 1 Q96KB5;Q96KB5-2;E5RFX4 Q96KB5 PBK Lymphokine-activated killer T-cell-originated protein kinase 1 14712700.0 1027700.0 3870900.0 9814100.0 True False 1559096.0349339235 3180107.6515202587 7874338.833327159 1.0 2.0397124874062267 5.050579731389596 20.572278365131368 -6.952242136838564 0.5336616573313523 0.9537279649463791 6.274104953893351 0.9993656931268957 0.04326029716893256 0.08259771987700455 0.032331547655181925 0.04800679228850348 0.24910560535589157 1.116240724648686e-07 6.952242136838564 5.320376988946972 GLK(ub)YLHQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLKYLHQEK 9 1 Q96KB5;Q96KB5-2;E5RFX4 Q96KB5 PBK Lymphokine-activated killer T-cell-originated protein kinase 1 3161080.0 574180.0 1140000.0 1446900.0 True False 786469.8626310613 1089631.030524126 1105172.0198408866 1.0 1.3854708009775065 1.4052312394319053 19.58503195734954 -11.839737800776804 0.46763972250424596 5.25079363597636e-19 1.4049038886983138 0.9998475030536227 0.0023036277119802048 5.400421351771629 0.2324056556804802 5.376981741462204 0.004289996503206524 1.4463126982865918e-12 11.839737800776804 1.4049038886983138 GLK(ub)YLHQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLKYLHQEK 9 1 Q96KB5;Q96KB5-2;E5RFX4 Q96KB5 PBK Lymphokine-activated killer T-cell-originated protein kinase 1 8985700.0 1027700.0 3881600.0 4076400.0 True False 1330377.9089955937 3665585.547799377 3334537.027396123 1.0 2.7552964635190116 2.506458506901716 20.343404687223817 -10.055031107393079 9.277010572275772 0.9999999972393171 2.630877485210364 0.9828393249326877 0.10158767039153183 5.9765037838779316e-09 4.73979941796177e-10 0.09836183963445519 0.032787279633867565 8.80985768010763e-11 10.055031107393079 1.6308774879710466 GLKPGVVYEGQLISIQQYGHQEVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLKPGVVYEGQLISIQQYGHQEVTR 25 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 18779300.0 5302900.0 7272000.0 6204400.0 False True 6952153.25335665 6187045.94603398 5562428.204807292 1.0 0.8899467144293375 0.8001014940402287 22.72902845461525 -6.973440122986817 0.15539548753776164 1.0968858782783704 0.5907882259460236 0.9999982940317301 0.00010661590736385714 0.07520134641100946 0.004774814112458467 0.0043475727940778764 0.0109705069325605 1.0630651400022049e-07 6.973440122986817 -0.5060976523323467 GLKPGVVYEGQLISIQQYGHQEVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLKPGVVYEGQLISIQQYGHQEVTR 25 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 25596600.0 5302900.0 7544700.0 12749000.0 False True 7263525.435484099 7211350.207013482 9737948.773896933 1.0 0.9928168175448622 1.3406642353483984 22.79223851613814 -6.902187606714038 0.9473532740747385 0.9863929775398179 1.3788406419003938 0.9876230517678055 0.018057295408572913 0.10981233908274524 0.1684853508807201 0.014234982112167158 0.037459715120646254 1.2525999593921518e-07 6.902187606714038 0.3924476643605759 GLLEFEHQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLLEFEHQR 9 0 Q14697;F5H6X6;Q14697-2;E9PKU7;E9PNH1 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 21927300.0 2983100.0 7484200.0 11460000.0 False True 3910872.988381498 6367586.533183113 10274229.132082323 1.0 1.628175231489253 2.627093531956986 21.89905925241431 -6.964268666483305 0.37038885214636275 0.9235203041535814 3.3665405859421633 0.9998972677758 0.006790721368862186 0.07821001457751574 0.015740330247978784 0.013158758931907856 0.08481982187286959 1.0857537387600123e-07 6.964268666483305 2.443020281788582 GLLEFEHQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLLEFEHQR 9 0 Q14697;F5H6X6;Q14697-2;E9PKU7;E9PNH1 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 16085900.0 5779700.0 0.0 10306200.0 False True 5596226.587147832 0.0 7606697.040627394 1.0 0.0 1.3592546552880405 22.41602294668326 -6.709552389293863 1.7966607206105978 0.38494391744367995 1.3560380422148193 0.4630234294523764 0.4214240929610538 0.37598424508189304 2.3655415486560707 0.18667430166796575 0.47452286168128693 1.9518552659651976e-07 6.709552389293863 0.9710941247711393 GLLEFEHQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLLEFEHQR 9 0 Q14697;F5H6X6;Q14697-2;E9PKU7;E9PNH1 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 23951200.0 2983100.0 10625900.0 10342200.0 False True 4086032.685246307 10156412.602847654 7899585.364295003 1.0 2.4856415465103954 1.9333142862068942 21.962269313937202 -9.99934636083723 5.798449048310784 0.9999980929658113 2.2094779163590004 0.8647468675614108 0.22548665979675364 5.5586758156372795e-06 9.59427674979538e-07 0.21832686425225045 0.07277550651521315 1.0015061929633072e-10 9.99934636083723 1.2094798233931892 GLLGALTSTPYSPTQHLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLLGALTSTPYSPTQHLER 19 0 Q9NUQ9;E5RI16 Q9NUQ9 FAM49B Protein FAM49B 0 17167000.0 3169900.0 7627500.0 6369600.0 False True 4155769.5973552717 6489506.731762128 5710534.893517588 1.0 1.5615655728103994 1.3741221113778224 21.986684240417308 -10.102275923424214 4.530984986756303 0.9999646055145769 1.467843841943616 0.8925442234856742 0.07652347279250798 53278953.45646324 1.2745337455563601 22258.0437093534 0.02619602012591542 7.901764400293809e-11 10.102275923424214 0.46787923642903906 GLLGALTSTPYSPTQHLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLLGALTSTPYSPTQHLER 19 0 Q9NUQ9;E5RI16 Q9NUQ9 FAM49B Protein FAM49B 0 19353600.0 4722700.0 5783700.0 8847200.0 False True 4572780.473575285 8093161.571597058 6529852.909689187 1.0 1.769855696848994 1.4279830285803643 22.124640230370137 -10.22474805942585 4.712741118811486 0.9998670137756497 1.5989193627170146 0.8036175287115179 0.1395689323849992 0.00019505917108039722 3.208749877236705e-05 0.1351667556990494 0.04504567923011929 5.960077960906647e-11 10.22474805942585 0.5990523489413649 GLLGALTSTPYSPTQHLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLLGALTSTPYSPTQHLER 19 0 Q9NUQ9;E5RI16 Q9NUQ9 FAM49B Protein FAM49B 0 19581000.0 3169900.0 14059000.0 2352100.0 False True 4341897.693326496 13437826.89310411 1796582.4230200807 1.0 3.0949202036146715 0.4137781564456093 22.0498943019402 -6.698236394253053 1.837044498552738 2.3031011884522665 0.42198829306232033 0.40924197816381647 0.8845808308770661 0.3992150856055125 2.6179618670950475 0.38432066302242335 0.9905707272594931 2.0033812542849725e-07 6.698236394253053 -1.881112895389946 GLLGCNIIPLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLLGCNIIPLQR 12 0 J3KN29;O00233;O00233-3 J3KN29 PSMD9 26S proteasome non-ATPase regulatory subunit 9 0 2949500.0 1285700.0 0.0 1663800.0 False True 1761058.0347360682 0.0 1270844.7070366088 1.0 0.0 0.7216370397623334 20.74801102252869 -10.62586378297374 8.90540261568452 1.0002977080210853 0.3608185216955295 0.5112516796629032 0.29460708781837536 0.0017421089410066372 7.319009684335928e-05 0.2853742954524834 0.09508402873293609 2.3666618876489285e-11 10.62586378297374 -0.6394791863255558 GLLHIFYIPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLLHIFYIPR 10 0 Q9Y6Y9 Q9Y6Y9 LY96 Lymphocyte antigen 96 0 9855100.0 2691500.0 4558700.0 2604900.0 False True 3528582.5645230804 3878559.729673418 2335369.9359652055 1.0 1.0991834989689806 0.66184364210303 21.75065733701239 -6.8471047737186685 1.2490001485470688 1.0528238663224336 0.6453146444969033 0.9359842804409989 0.04736849142331397 0.16066934318672013 0.4837876250501904 0.029697513797988625 0.06860591973667945 1.421985691117781e-07 6.8471047737186685 -0.4075092218255303 GLLHIFYIPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLLHIFYIPR 10 0 Q9Y6Y9 Q9Y6Y9 LY96 Lymphocyte antigen 96 0 11057940.0 6299100.0 2444340.0 2314500.0 False True 6099138.518453021 3420377.709064705 1708263.016488338 1.0 0.5607968565915185 0.28008267254792896 22.540174050864298 -8.428045807024228 0.21976331466238677 1.2714479829770104 2.177098733355131e-22 0.9996151731234596 0.005811918298554938 0.13120520599251775 0.0540779040209458 0.13185933897327176 0.11737723762560498 3.732107914715081e-09 8.428045807024228 -1.2714479829770104 down GLLHIFYIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLLHIFYIPR 10 0 Q9Y6Y9 Q9Y6Y9 LY96 Lymphocyte antigen 96 0 16819600.0 2691500.0 4267700.0 9860400.0 False True 3686620.285052608 4079138.9026033524 7531576.601312515 1.0 1.106471127265862 2.042948830897848 21.813867398535283 -6.928375418092299 0.7600040715806352 0.9848685046147224 2.22748699121971 0.996209393048365 0.02884922497865922 0.093489724549333 0.08187564859481941 0.02603362013277124 0.08550417327906414 1.1793007694685178e-07 6.928375418092299 1.2426184866049876 up GLLHIFYIPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLLHIFYIPR 10 0 Q9Y6Y9 Q9Y6Y9 LY96 Lymphocyte antigen 96 0 11955700.0 6299100.0 1391200.0 4265400.0 False True 5237980.747445115 1383705.3294684212 5157275.419018679 1.0 0.2641677005291284 0.9845922823473912 22.320579326298574 -10.860464611465067 11.151431233909545 1.0104406954624126 0.6243799914382598 0.2660330669044455 0.2941121039354492 0.07320699765716224 0.0009160212508437934 0.2730712739179317 0.09492427337166832 1.3789083088904929e-11 10.860464611465067 -0.3860607040241527 GLLHPQQLHLLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLLHPQQLHLLSR 13 0 Q6PJT7;Q6PJT7-5;Q6PJT7-9;Q6PJT7-2;H0YJA2;G3V411 Q6PJT7 ZC3H14 Zinc finger CCCH domain-containing protein 14 0 5950600.0 1178600.0 2137100.0 2634900.0 False True 1545156.0135786363 1818253.0103505556 2362265.8237455236 1.0 1.176743962662655 1.528820263446687 20.559321082957204 -6.960123080835398 0.4336965790097192 0.9865511182972825 1.7325973676052724 0.9997747341071037 0.003299089142200303 0.079657187868642 0.020969151517840037 0.004608215147088598 0.02920901357775781 1.0961674937595667e-07 6.960123080835398 0.7460462493079899 GLLHPQQLHLLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLLHPQQLHLLSR 13 0 Q6PJT7;Q6PJT7-5;Q6PJT7-9;Q6PJT7-2;H0YJA2;G3V411 Q6PJT7 ZC3H14 Zinc finger CCCH domain-containing protein 14 0 6235500.0 1178600.0 2620000.0 2436900.0 False True 1614360.2704673975 2504239.7368186093 1861354.4095309011 1.0 1.5512273081977974 1.1529981526316877 20.622531144480096 -10.136726424218576 9.341758092388314 0.999999996973328 1.3521127304147424 0.510380912755391 0.16257637197273203 1.0181649542015741e-08 1.0043718966169152e-09 0.15741389762995253 0.05247129842810111 7.299171632897086e-11 10.136726424218576 0.35211273344141447 GLLHPQQLHLLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLLHPQQLHLLSR 13 0 Q6PJT7;Q6PJT7-5;Q6PJT7-9;Q6PJT7-2;H0YJA2;G3V411 Q6PJT7 ZC3H14 Zinc finger CCCH domain-containing protein 14 0 5882100.0 2409700.0 2347500.0 1124900.0 False True 2003772.3178102395 2334853.5515577313 1360111.3890500583 1.0 1.1652289687828923 0.6787754162291322 20.93428715838265 -6.8150852238856245 1.393291736471701 1.089522371712415 0.6692587031942899 0.8726309417173892 0.07208027801770753 0.19995176406567888 0.76403722115754 0.04066950256680887 0.09386852060786323 1.5307870378311878e-07 6.8150852238856245 -0.420263668518125 GLLINFIHHNWPSLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLLINFIHHNWPSLLK 16 0 Q02880;Q02880-2;E9PCY5 Q02880 TOP2B DNA topoisomerase 2-beta;DNA topoisomerase 2 0 88511000.0 21351000.0 35262000.0 31898000.0 False True 32391027.967183255 28969220.596736476 25593346.318609957 1.0 0.8943594079844098 0.7901368966906416 24.949090918686846 -6.971291934201699 0.22520891938848478 1.0450107075341433 0.6365246326357217 0.9999907752472238 0.0002601562234681501 0.0758857448061586 0.007512841037422526 0.0027751096721488335 0.010450147724175273 1.0683364984371996e-07 6.971291934201699 -0.4084860748984216 GLLINFIHHNWPSLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLLINFIHHNWPSLLK 16 0 Q02880;Q02880-2;E9PCY5 Q02880 TOP2B DNA topoisomerase 2-beta;DNA topoisomerase 2 0 71458000.0 17814000.0 23018000.0 30626000.0 False True 14813130.294008227 22893997.465284716 37029755.00137526 1.0 1.5455205625609818 2.49979270190808 23.82037320574608 -6.96257713166647 0.3974485234976522 0.9460431843777092 3.133970989702245 0.9998541631359773 0.0074851418587565345 0.0787930499965535 0.017821568970932202 0.012284299835449004 0.08002979301123533 1.0899908903857522e-07 6.96257713166647 2.187927805324536 GLLINFIHHNWPSLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLLINFIHHNWPSLLK 16 0 Q02880;Q02880-2;E9PCY5 Q02880 TOP2B DNA topoisomerase 2-beta;DNA topoisomerase 2 0 74370130.0 21351000.0 29223130.0 23796000.0 False True 27639290.391130626 27596837.12630417 19465372.167578768 1.0 0.9984640247913137 0.7042645412425332 24.720217240779295 -6.908045734001567 0.90894247634054 1.0096815064208444 0.6677919192235711 0.9901628991139961 0.0137913191583052 0.10572446844845733 0.1458830328178863 0.011183153122225781 0.030468055425396257 1.235817287085062e-07 6.908045734001567 -0.34188958719727336 GLLINFIHHNWPSLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLLINFIHHNWPSLLR 16 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 0 226268600.0 35838500.0 67240700.0 123189400.0 False True 54369624.64530447 55241071.73101305 98840961.09416787 1.0 1.0160281975715983 1.817944518450967 25.696297532365445 -6.911223056548278 0.8873607276779754 0.9761197801437415 1.9243373928318885 0.9913747499913852 0.0354642733356218 0.10361589167689758 0.13442119971248148 0.02921153934942841 0.08133744388754122 1.2268089720328625e-07 6.911223056548278 0.9482176126881471 GLLINFIHHNWPSLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLLINFIHHNWPSLLR 16 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 0 164587800.0 35838500.0 51754600.0 76994700.0 False True 46393644.73244972 48874411.01405024 62982454.632336505 1.0 1.0534721144653971 1.3575664295304624 25.467423854457895 -6.936979132738019 0.6870898399500932 0.996343376213514 1.432763163566358 0.9977408960267112 0.007484806226279522 0.08917209949425649 0.06108996139393768 0.007128829683619721 0.02653979731479095 1.156167793154951e-07 6.936979132738019 0.43641978735284404 GLLK(ub)ALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLLKALK 7 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 11090800.0 5321900.0 5099800.0 669100.0 True False 6977062.437352917 4338929.7188647045 599867.9504604088 1.0 0.6218848917899157 0.08597715096383708 22.73418831362369 -7.560944972427919 0.54001709105723 1.0092943744358376 9.708417397257503e-26 0.9953172370989257 0.025661324347721986 0.11707412858616932 0.08860735958031725 0.026835416674508932 0.0721842186699219 2.7482423489231262e-08 7.560944972427919 -1.0092943744358376 down GLLK(ub)ALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLLKALK 7 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 11662200.0 6383600.0 4054300.0 1224300.0 True False 6180956.11220598 5673203.132895195 903619.1017872852 1.0 0.9178520329066746 0.14619406534902316 22.559398590568193 -6.929300262510774 0.7707906775695293 1.0128890801567758 1.4552753952767926e-18 0.9959716542328632 0.024409672028860813 0.09356525356412586 0.08500079388107659 0.02188994375863868 0.07045637999490839 1.1767920817115373e-07 6.929300262510774 -1.0128890801567758 down GLLK(ub)ALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLLKALK 7 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 9809270.0 5321900.0 3524800.0 962570.0 True False 7289550.248939799 3369062.6810451257 735230.79075143 1.0 0.46217702958219214 0.1008609263456772 22.79739837514658 -8.26938552271642 0.38443129201789206 1.0875876235403903 6.315048939951372e-17 0.9973970032989348 0.018847754581310567 0.11192595851590768 0.10091804924195008 0.07226934050923689 0.08381629442246616 5.37792173062111e-09 8.26938552271642 -1.0875876235403903 GLLK(ub)ALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLLKALK 7 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 15794540.0 6383600.0 8703700.0 707240.0 True False 5308246.241429828 8656811.440550817 855120.614091709 1.0 1.6308232600413466 0.16109286856695892 22.33980386600247 -6.790067529263667 1.495945168709344 1.3525467622163627 0.1454113171235432 0.8015462622312366 0.2681870205841251 0.23527029071768651 1.0400998179108463 0.14110582477771613 0.33036382806249676 1.6215579386694233e-07 6.790067529263667 -1.2071354450928196 GLLK(ub)ALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLLKALK 7 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 11059800.0 6411400.0 1547300.0 3101100.0 True False 8299683.687588155 1461191.394813986 2536731.6199730434 1.0 0.17605386540202 0.3056419636529792 22.984624923730273 -10.24717289526549 5.6652819208811716 1.0000412429179335 0.24084791538630135 0.9786132393231121 0.052904119575474806 2.756050254467325e-05 3.662302780891045e-06 0.05122696108058558 0.017074731171789932 5.660139106105665e-11 10.24717289526549 -0.7591933275316322 GLLK(ub)TLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLLKTLQK 8 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 1 9362900.0 4716500.0 3636200.0 1010200.0 True False 4566777.28918157 5088153.622532492 745598.3146496081 1.0 1.1141672344272255 0.1632657490033261 22.122745003965385 -6.876906697670865 1.0968571860120224 1.068246205475658 0.09973661675832166 0.9711056814901765 0.07205928223199148 0.13040775543621308 0.2891168369693062 0.050738451392735924 0.12179513984763643 1.3276796612134273e-07 6.876906697670865 -0.9685095887173364 down GLLK(ub)TLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLLKTLQK 8 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 1 11253000.0 5403900.0 2217200.0 3631900.0 True False 8198111.378008588 1821523.3369373304 2914053.3730816813 1.0 0.22218816663354463 0.35545423070228366 22.96686015961513 -10.722014774834493 5.88906714014149 1.0164023149899708 0.2888211986679141 0.974340190813667 0.05440564283291037 0.011420810224447327 0.0005391029487766451 0.05134866085961733 0.017559345719297563 1.8966413957783886e-11 10.722014774834493 -0.7275811163220567 GLLK(ub)TLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLLKTLQK 8 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 1 5482800.0 2359800.0 2065400.0 1057600.0 True False 3232281.8311971505 1974143.7986355529 807816.6619557141 1.0 0.61075856058764 0.2499214809051847 21.624121565292555 -7.626815552222831 0.30971396052706 1.089226622310603 8.59606889431892e-10 0.9995172843365185 0.006729463041233928 0.12580955097486468 0.039777396450501094 0.02927610126018859 0.07340041716524083 2.3614809570231744e-08 7.626815552222831 -1.0892266214509962 down GLLK(ub)TLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLLKTLQK 8 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 1 12911770.0 4716500.0 7259800.0 935470.0 True False 3921978.7263775533 7220690.016442525 1131072.4518754166 1.0 1.8410834224773451 0.28839331643190885 21.90315027939966 -6.759623174405586 1.614080430428266 1.4887985264376666 0.2828760188491981 0.6892935159819097 0.35374235231757256 0.2835837890854153 1.456067883977225 0.17293161334346285 0.41570487739240064 1.7393093259480275e-07 6.759623174405586 -1.2059225075884685 GLLK(ub)TLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLLKTLQK 8 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 1 12448500.0 5403900.0 4620800.0 2423800.0 True False 6995455.07679409 4363648.417990345 1982693.2702881761 1.0 0.6237833522033192 0.28342591704510156 22.73798648170758 -7.584316979954532 0.28292618076590215 1.1073041878762564 2.6128398098006313e-10 0.9997086109061675 0.00499577668210638 0.12737005961522707 0.033027775046015964 0.02891733653345949 0.0710538826531855 2.6042520820596916e-08 7.584316979954532 -1.1073041876149725 down GLLKPGLNVVLEGPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLLKPGLNVVLEGPK 15 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 0 14318400.0 4485800.0 6154700.0 3677900.0 False True 5880927.240548992 5236442.750832695 3297346.1889079926 1.0 0.8904110757785648 0.5606847447750741 22.48761221075949 -6.951385078073373 0.543424695418728 1.0047480504738493 0.4310313581205172 0.9993055455608075 0.0049201271778238605 0.08293428161103364 0.033697089323745856 0.005386484056830661 0.027321392078434346 1.1184457457635581e-07 6.951385078073373 -0.5737166923533321 GLLKPGLNVVLEGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLLKPGLNVVLEGPK 15 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 0 17618100.0 5461100.0 6907100.0 5249900.0 False True 5287740.369755005 9665141.050050667 3874793.6963759437 1.0 1.827839563631691 0.7327881903088734 22.334219910983986 -6.704497780071566 1.814671735784247 1.5117700742671065 0.7357396680159796 0.43900387514393 0.3491622929240714 0.38624682360753987 2.475755280863623 0.1533180731627137 0.39214235147741766 1.974704973234367e-07 6.704497780071566 -0.776030406251127 GLLKPGLNVVLEGPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLLKPGLNVVLEGPK 15 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 0 25388300.0 3854300.0 11088000.0 10446000.0 False True 5847254.887073881 9109259.769060576 8381343.52135556 1.0 1.5578694524156596 1.433380908344463 22.479328050379912 -10.035560410430952 4.643107231472634 0.9999839646820056 1.4956251802772182 0.9548211322444619 0.05082223537164786 8105098.044151733 8768379.548759798 1107.6268183435413 0.01739780277677622 9.21381715478714e-11 10.035560410430952 0.4956412155952127 GLLKPGLNVVLEGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLLKPGLNVVLEGPK 15 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 0 22410800.0 4485800.0 5126000.0 12799000.0 False True 6144321.484186871 4899516.370584804 9776139.803679265 1.0 0.7974056017729999 1.591085334457076 22.55082227228238 -6.839017535692707 1.28707299797254 0.8922105708197381 1.6166664209272616 0.9227312238663662 0.09359575923543859 0.1699506238122008 0.547324592433771 0.05703298284833037 0.13135144304569585 1.448713357049426e-07 6.839017535692707 0.7244558501075236 GLLKPGLNVVLEGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLLKPGLNVVLEGPK 15 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 0 11087200.0 5461100.0 2916100.0 2710000.0 False True 4541146.61775055 2900390.390499466 3276648.470375725 1.0 0.6386912017247685 0.7215465049218799 22.114625186418262 -10.501579712615568 6.807263284212484 1.0001294525237718 0.6801188533233263 0.9520924742374018 0.033825535886085785 6.648190771244276e-05 4.867762426161014e-06 0.032764552992963526 0.010917144763612635 3.150796014020499e-11 10.501579712615568 -0.3200105992004455 GLLLYGPPGTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLLLYGPPGTGK 12 0 K7EM02;K7EIJ8;Q8IYT4-2;Q8IYT4 K7EM02 KATNAL2 Katanin p60 ATPase-containing subunit A-like 2 0 13829700.0 2953800.0 5290700.0 5585200.0 False True 3872460.4046398927 4501348.182987075 5007297.0810214775 1.0 1.162400053876255 1.2930531387801538 21.884819057061623 -6.973592630579838 0.14919816658323043 0.8464041708051003 1.612482964733402 0.9999985764196864 0.0001429076282616888 0.07515324810711081 0.004556898613573111 0.006721611770781656 0.01635244192132081 1.062691897767552e-07 6.973592630579838 0.7660787939283017 GLLLYGPPGTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLLLYGPPGTGK 12 0 K7EM02;K7EIJ8;Q8IYT4-2;Q8IYT4 K7EM02 KATNAL2 Katanin p60 ATPase-containing subunit A-like 2 0 17563000.0 2953800.0 5984900.0 8624300.0 False True 4045899.6834435775 5720467.32858232 6587417.963033921 1.0 1.4138925272891274 1.6281713533310314 21.948029118584515 -10.877952448278869 0.12214641605108739 5.031649193280569e-21 2.0361603991144106 0.9998046251062623 0.003644391390305489 3.057727303315923 0.07134540736518193 1.1378885152456455 0.2679957006837672 1.3244865477834138e-11 10.877952448278869 2.0361603991144106 GLLNAIVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLLNAIVIK 9 0 P04181;P04181-2 P04181 OAT Ornithine aminotransferase, mitochondrial;Ornithine aminotransferase, hepatic form;Ornithine aminotransferase, renal form 0 8213700.0 1543900.0 2017700.0 4652100.0 False True 2024067.851148867 1716667.0249330015 4170745.3180942563 1.0 0.8481272127110838 2.0605758427154153 20.948826222437056 -6.875503549836074 1.1046315579936918 0.9104734748638788 2.1394031835352023 0.9698710321210589 0.09361574613585584 0.1316845255246526 0.29702538591180844 0.06552892434204119 0.15679856106453258 1.3319761549624696e-07 6.875503549836074 1.2289297086713236 up GLLNAIVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLLNAIVIK 9 0 P04181;P04181-2 P04181 OAT Ornithine aminotransferase, mitochondrial;Ornithine aminotransferase, hepatic form;Ornithine aminotransferase, renal form 0 6994700.0 2662400.0 1471200.0 2861100.0 False True 2577883.569324081 2058657.832206645 2111692.078839831 1.0 0.7985844887270931 0.8191572745830081 21.297755674857722 -9.983178008325181 5.187598924728671 1.0000010149909724 0.8088708816538981 0.9913853730749138 0.008398804659777345 9.85996734779917e-08 1.9318213230759015e-08 0.008132150780376156 0.0027107025473687377 1.0394940114047123e-10 9.983178008325181 -0.1911301333370743 GLLNAIVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLLNAIVIK 9 0 P04181;P04181-2 P04181 OAT Ornithine aminotransferase, mitochondrial;Ornithine aminotransferase, hepatic form;Ornithine aminotransferase, renal form 0 12703700.0 1543900.0 6040700.0 5119100.0 False True 2114721.5523287063 5773801.900076401 3910074.0111738853 1.0 2.730289429224552 1.8489781819588296 21.012036283959947 -10.37686010356652 5.227990671035682 0.9992876444406098 2.289633805591747 0.7405996430814648 0.3597938100630034 0.0029887843792608523 0.000356241691363628 0.3485352968824491 0.11612295287018218 4.198942199800368e-11 10.37686010356652 1.290346161151137 GLLNAIVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLLNAIVIK 9 0 P04181;P04181-2 P04181 OAT Ornithine aminotransferase, mitochondrial;Ornithine aminotransferase, hepatic form;Ornithine aminotransferase, renal form 0 3980700.0 2662400.0 1318300.0 0.0 False True 2213903.5643183743 1311198.0562379386 0.0 1.0 0.5922561747361547 0.0 21.078160950292 -7.671091389938683 0.6555801650609937 0.9991059627675402 5.026164343125856e-15 0.9873531266017379 0.046170685726223654 0.12070599369113144 0.1497870267069416 0.042655489752397406 0.07771595472139649 2.1325960970952857e-08 7.671091389938683 -0.9991059627675352 down GLLPGCVYHVQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLLPGCVYHVQLK 13 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 87241000.0 23422000.0 29269000.0 34550000.0 False True 30706468.818970654 24902179.28966842 30975097.42700213 1.0 0.8109750240732236 1.008748274170344 24.872039279088916 -11.140830396100883 10.318686304650209 3.559141400952889 0.909861650183223 0.21689238202190808 0.08074059125163141 0.039681241344054714 0.000541574295447008 0.0006526068990426181 0.026058913773375717 7.2305212014405335e-12 11.140830396100883 -2.649279750769666 GLLPGCVYHVQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLLPGCVYHVQLK 13 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 46737700.0 24398000.0 9429700.0 12910000.0 False True 23623498.84479 13195028.385235876 9528483.708301783 1.0 0.5585552111450226 0.4033476908270607 24.493719320403 -13.999999999999998 0.14569009896716828 3.121682789605007 0.22382787758808204 0.9995812551007842 0.005172147093511401 11.944137038032347 0.1199710434082118 7.1847378854349655 0.16118040656751842 1.0000000000000041e-14 13.999999999999998 -2.897854912016925 GLLPGCVYHVQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLLPGCVYHVQLK 13 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 73415000.0 23422000.0 22208000.0 27785000.0 False True 32081746.355750363 21226777.12796474 21222755.250037376 1.0 0.6616465604017853 0.6615211969666791 24.935249340611808 GLLQLQWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLLQLQWK 8 0 O94826 O94826 TOMM70A Mitochondrial import receptor subunit TOM70 0 14453500.0 2690500.0 6772600.0 4990400.0 False True 3527271.5548390658 5762154.479388035 4474041.279297001 1.0 1.6336010397279823 1.2684141863585925 21.750121218447735 -10.032819622062435 4.322801232665868 0.9999711193748098 1.4510076128609044 0.6703640822109118 0.14908690888911807 103902025.30230084 222717262.78469646 45298.00407918152 0.05456020360135608 9.272148487057481e-11 10.032819622062435 0.45103649348609465 GLLQLQWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLLQLQWK 8 0 O94826 O94826 TOMM70A Mitochondrial import receptor subunit TOM70 0 7601500.0 3685100.0 2071200.0 1845200.0 False True 3568118.5176217537 2898240.9611653103 1361886.7651865555 1.0 0.8122602841951184 0.3816820429200007 21.766732105531226 -6.957281577305556 0.47218807322269596 1.0111342677033952 0.1650912565028739 0.9996557125182491 0.004802679766203756 0.08068687298074517 0.024830568926371418 0.00597819769680089 0.035532740691645755 1.1033630162365844e-07 6.957281577305556 -0.8460430112005213 down GLLQLQWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLLQLQWK 8 0 O94826 O94826 TOMM70A Mitochondrial import receptor subunit TOM70 0 12854700.0 2690500.0 3338300.0 6825900.0 False True 3685250.558028623 3190802.867718155 5213763.003823283 1.0 0.8658306450199776 1.4147648638067958 21.813331279970626 -6.842090528022935 1.2726715547605971 0.9286340177304075 1.4335776086721959 0.9279867988027647 0.06270248298787252 0.16637054415981245 0.5225435682417332 0.03861914203697369 0.0890261233584378 1.4384986941410592e-07 6.842090528022935 0.5049435909417883 GLLQLQWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLLQLQWK 8 0 O94826 O94826 TOMM70A Mitochondrial import receptor subunit TOM70 0 6545200.0 3685100.0 1136800.0 1723300.0 False True 3064323.9276102874 1130675.832762866 2083634.0623610653 1.0 0.36898051885938293 0.6799653403437629 21.547137380965502 -10.542568207896371 6.435436787324918 1.00054125492675 0.5244729296016536 0.7571360373253073 0.12695902173120774 0.0009869865715422537 7.015510896412606e-05 0.12305951541787129 0.0409758480679794 2.867027060760578e-11 10.542568207896371 -0.47606832532509646 GLLSDSMTDVPVDTGVAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLLSDSMTDVPVDTGVAAR 19 0 O43399;O43399-5;O43399-7;A0A087WYR3;A0A087WZ51;O43399-2;O43399-4;O43399-3 O43399;O43399-2 TPD52L2 Tumor protein D54 0 7747890.0 2137900.0 954490.0 4655500.0 False True 2070033.5347272928 1335622.8345995948 3436084.887993719 1.0 0.6452179697540747 1.659917499088434 20.98122270902601 -6.812246527360327 1.4051019402056149 0.8071563560271858 1.678591077273172 0.8656084550395735 0.1541333454169684 0.20375043357027978 0.7924015374875618 0.0862444750022179 0.1993028179803721 1.5408255546822998e-07 6.812246527360327 0.8714347212459862 GLMNGYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLMNGYR 7 0 Q14444-2;Q14444;G3V153 Q14444-2 CAPRIN1 Caprin-1 0 2851080.0 873380.0 1191700.0 786000.0 False True 1145009.6378239507 1013903.0052102177 704672.2598443895 1.0 0.8854973545350269 0.6154291078139688 20.12692831121172 -6.95669702101694 0.4797268446210457 1.0064990939767862 0.4831727761335007 0.9996273905316986 0.00311214261659982 0.08090285797095322 0.025656763203213973 0.003805776259959042 0.02227854738704261 1.1048491324054439e-07 6.95669702101694 -0.5233263178432854 GLMNGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLMNGYR 7 0 Q14444-2;Q14444;G3V153 Q14444-2 CAPRIN1 Caprin-1 0 3835540.0 1295100.0 1760500.0 779940.0 False True 1253987.759401899 2463476.830886215 575650.3163015401 1.0 1.9645142565515894 0.4590557698713916 20.25809183489924 -6.733673201980582 1.7096799734353063 1.57807064660166 0.45931657877177917 0.5761798090753734 0.40535876895000944 0.32944472300110217 1.888117457584487 0.18775676675349448 0.464008727402464 1.8464042793189125e-07 6.733673201980582 -1.1187540678298808 GLMNGYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLMNGYR 7 0 Q14444-2;Q14444;G3V153 Q14444-2 CAPRIN1 Caprin-1 0 3894310.0 1295100.0 2273600.0 325610.0 False True 1076933.032658025 2261351.665525732 393693.5455494616 1.0 2.0998071346594247 0.3655691984651725 20.038497110333516 -6.735345013181875 1.7037213132415838 1.6578887283518717 0.3655479939487841 0.583859913362901 0.4621718608407695 0.326312290106509 1.8578811151472223 0.2147666597652993 0.5297386819927238 1.8393102320163525e-07 6.735345013181875 -1.2923407344030875 GLMYPYIFHVLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLMYPYIFHVLTK 13 0 Q9NZB2;Q9NZB2-6;Q9NZB2-4;Q9NZB2-2;Q9NZB2-5;A0A0C4DH52 Q9NZB2 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 0 2973220.0 566320.0 1279000.0 1127900.0 False True 742451.0042506815 1088178.1855029522 1011195.7275807734 1.0 1.4656565608678727 1.3619696408132984 19.501936297310667 -10.083767158687403 4.796462788097079 0.999986560203717 1.413813100839631 0.9550305066932996 0.04233000791411165 7.549414327027435e-06 1.4420086518620833e-06 0.04098750395945535 0.013661951299369639 8.245800843638078e-11 10.083767158687403 0.41382654063591406 GLMYPYIFHVLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLMYPYIFHVLTK 13 0 Q9NZB2;Q9NZB2-6;Q9NZB2-4;Q9NZB2-2;Q9NZB2-5;A0A0C4DH52 Q9NZB2 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 0 7095100.0 2571100.0 1580600.0 2943400.0 False True 2489481.8378489832 2211741.822720108 2172435.2398927514 1.0 0.88843460879841 0.8726455469021724 21.24741405950589 -13.999999998525984 0.27543636171147534 1.8867966019612883 0.8676746391467056 0.9995951186892313 0.0011405144897568326 15.156567003950597 0.16618939295287222 7.550720633254291 0.006384069658813944 1.0000000033940463e-14 13.999999998525984 -1.0191219628145827 GLMYPYIFHVLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLMYPYIFHVLTK 13 0 Q9NZB2;Q9NZB2-6;Q9NZB2-4;Q9NZB2-2;Q9NZB2-5;A0A0C4DH52 Q9NZB2 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 0 6027520.0 566320.0 1532100.0 3929100.0 False True 775703.8082225492 1464406.7560228219 3001127.5023545735 1.0 1.88784267977022 3.8689090739819485 19.56514635883356 -6.957849155644707 0.46475444951060474 0.944917006707675 4.892335399479066 0.9996819244267656 0.02138800228247403 0.08047857037442822 0.024039255361833753 0.027129203127297812 0.16357807360493956 1.1019219758053317e-07 6.957849155644707 3.947418392771391 GLMYPYIFHVLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLMYPYIFHVLTK 13 0 Q9NZB2;Q9NZB2-6;Q9NZB2-4;Q9NZB2-2;Q9NZB2-5;A0A0C4DH52 Q9NZB2 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 0 6494600.0 2571100.0 1411300.0 2512200.0 False True 2137983.569042579 1403697.0467788822 3037489.4048995944 1.0 0.6565518402966394 1.4207262622976227 21.027819334940165 -6.784503718657623 1.5180646862411653 0.8066682392826279 1.4276850491301443 0.7830812621912984 0.14554737176154323 0.24364072199263886 1.1091925149781 0.07549004116610104 0.17748570107323652 1.642465595960702e-07 6.784503718657623 0.6210168098475164 GLNIAASAAVQAATK(ub)SQGALAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLNIAASAAVQAATKSQGALAGR 23 1 E5RGS2;Q9H6H4 E5RGS2 REEP4 Receptor expression-enhancing protein;Receptor expression-enhancing protein 4 1 6550800.0 2297300.0 2546900.0 1706600.0 True False 1910306.737645957 2533179.3441799297 2063442.1695731443 1.0 1.3260589486804248 1.0801627450238143 20.86537287949639 -9.834148815964772 5.400277297396798 0.9999998972538974 1.20311084685506 0.4763593388044105 0.10038670478468678 68038504.48211074 5.5448001033285435 86.90928092558988 0.034365039176031564 1.465045740278777e-10 9.834148815964772 0.2031109496011626 GLNLTTPGESDGFCANK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLNLTTPGESDGFCANKLR 19 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2;I3L167;E7EP81 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 13249800.0 3834200.0 4992300.0 4423300.0 True False 5026673.33044562 4247468.299832985 3965619.3472896763 1.0 0.8449859421154073 0.7889152699202993 22.26117250465554 -13.999999999999998 0.14149790022927597 1.7415142166618804 0.7207613252168447 0.9995970261250684 0.0017921133697943303 11.935866985635306 0.11796267658053285 2.4417670669672384 0.06099237026143804 1.0000000000000041e-14 13.999999999999998 -1.020752891445036 GLNLTTPGESDGFCANK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLNLTTPGESDGFCANKLR 19 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2;I3L167;E7EP81 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 11970200.0 4265900.0 3474400.0 4229900.0 True False 4130481.3395355986 4861746.038756648 3121962.295720036 1.0 1.1770410368936002 0.7558349836464936 21.97787848309903 -6.792530762813213 1.4861876256267 1.098626385864042 0.7510376808890304 0.809397356025117 0.0753900321468106 0.23161645653488608 1.0105713280946642 0.039922108016935035 0.09329884646512498 1.6123868114930664e-07 6.792530762813213 -0.3475887049750115 GLNLTTPGESDGFCANK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLNLTTPGESDGFCANKLR 19 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2;I3L167;E7EP81 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 81974700.0 9834700.0 10579000.0 61561000.0 True False 14919958.912877928 8691094.795895746 49393441.36685521 1.0 0.5825146601706901 3.310561487151418 23.830740226864414 -6.867859758660264 1.145280883455005 0.7666566259628552 3.4640143215667667 0.962504119620671 0.2323234514343055 0.13892762414419307 0.34190692817219975 0.15761873371124924 0.3718646118586024 1.3556270975527438e-07 6.867859758660264 2.6973576956039116 up GLNLTTPGESDGFCANK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLNLTTPGESDGFCANKLR 19 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2;I3L167;E7EP81 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 13190100.0 3834200.0 5230300.0 4125600.0 True False 5251807.355358982 4999208.051710823 3151218.249399109 1.0 0.9519024049139186 0.600025483833405 22.324382566178432 -6.9317989475297 0.7318768364988865 1.0050100168764071 0.5243627863094816 0.9968800882361035 0.009959020357479528 0.09171459333976824 0.07318316786764537 0.00917220735245368 0.031529785781871836 1.1700409248996255e-07 6.9317989475297 -0.4806472305669255 GLNLTTPGESDGFCANK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLNLTTPGESDGFCANKLR 19 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2;I3L167;E7EP81 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 10665400.0 4265900.0 2739200.0 3660300.0 True False 3547284.8614129117 2724443.3859113674 4425651.806684975 1.0 0.7680362565599539 1.2476166926504466 21.758283758533306 -6.775223729667363 1.5548412632167152 0.8678385228623494 1.2508377559050383 0.749990339195094 0.09791321767322243 0.25807375082899325 1.231991078844655 0.04962061368763777 0.1175423573532915 1.6779393938852307e-07 6.775223729667363 0.3829992330426889 GLNLTTPGESDGFCANK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLNLTTPGESDGFCANKLR 19 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2;I3L167;E7EP81 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 56638500.0 9834700.0 7051800.0 39752000.0 True False 12731213.020919485 6659361.130969604 32517543.88996436 1.0 0.5230735767304477 2.5541591234497973 23.601866548956863 -6.8448346423263215 1.2598825498809043 0.7462290893468772 2.627558738905458 0.932428425101582 0.22542218147194198 0.16323162749229642 0.5012191165791803 0.14017969773742586 0.32346695026519523 1.429438113636295e-07 6.8448346423263215 1.8813296495585812 up GLNSK(ub)LLDIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLNSKLLDIR 10 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 11939100.0 4835500.0 3081800.0 4021800.0 True False 4681999.699318885 4312378.811374687 2968369.92858622 1.0 0.9210549099356053 0.633996180951922 22.158693411123274 -6.947068318313471 0.5901612909521198 1.0033163796251474 0.5372865355824067 0.9989505977052612 0.005094552464596632 0.08468496700687797 0.04100364980561034 0.00528082863114259 0.024049489307273558 1.1296182018903532e-07 6.947068318313471 -0.4660298440427407 GLNSK(ub)LLDIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLNSKLLDIR 10 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 40820200.0 10741200.0 19600000.0 10479000.0 True False 16295185.686905008 16102226.864501031 8407821.056891145 1.0 0.9881585379810037 0.5159696378082861 23.95794245618066 -6.912287852555149 0.8799953481214668 1.0135835216534494 0.4518607289551683 0.9917569611469826 0.020467498635178997 0.10292501099068344 0.13069951194376803 0.016948889968694543 0.047563496683954536 1.2238047864560137e-07 6.912287852555149 -0.5617227926982811 GLNSK(ub)LLDIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLNSKLLDIR 10 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 11060700.0 4835500.0 3190500.0 3034700.0 True False 4020932.4989714175 3173312.143235338 3669241.7391325557 1.0 0.7891980638936598 0.9125350251642307 21.93909868655755 -10.20537059467684 4.987926443659653 1.0000162189063342 0.8508665445634027 0.6609487335532712 0.05035210359032684 9.08256781608063e-06 1.446959398242378e-06 0.04875851493473416 0.01625107155423351 6.232028134947166e-11 10.20537059467684 -0.14914967434293147 GLNSK(ub)LLDIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLNSKLLDIR 10 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 42836100.0 10741200.0 17756300.0 14338600.0 True False 13904695.140705932 16768146.295957873 11729121.926460119 1.0 1.2059341198261297 0.8435367915491486 23.72906877827311 -6.752534029076735 1.6403620642441132 1.120717044732055 0.8426689213089198 0.6599022887801167 0.0865477718743486 0.2956164326251958 1.5657555321971 0.04166535349448085 0.10088872947267259 1.7679336861374546e-07 6.752534029076735 -0.2780481234231351 GLNSQSSDDHLNK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLNSQSSDDHLNKR 14 1 Q96HA1-2;A8CG34-2;Q96HA1-3;A8CG34;Q96HA1 Q96HA1-2 POM121;POM121C Nuclear envelope pore membrane protein POM 121;Nuclear envelope pore membrane protein POM 121C 1 2749760.0 936780.0 1256900.0 556080.0 True False 1228127.6517904233 1069375.419357826 498542.1758960151 1.0 0.870736374837615 0.4059367730782842 20.228029091786116 -6.947325438306932 0.5874837503774731 1.0054140469643489 0.24797233942174993 0.9989742433703833 0.008170020883464836 0.08457805854994445 0.04054825137622543 0.008492280845781769 0.03890953530372697 1.1289496199133665e-07 6.947325438306932 -0.757441707542599 down GLPFEAENK(ub)HVIDFFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLPFEAENKHVIDFFK 16 1 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 1 19522900.0 1832500.0 5862400.0 11828000.0 True False 2780036.4736950626 4816208.9168597385 9490190.615603438 1.0 1.7324265211737724 3.4136928437451863 21.406672380357058 -6.957264213433905 0.4724222090552023 0.9566224293908236 4.25870146873582 0.9996548606368811 0.018771999211103157 0.08069339537089552 0.024855846429011206 0.023353353510109306 0.13874141317999877 1.1034071315491228e-07 6.957264213433905 3.3020790393449966 GLPFEAENK(ub)HVIDFFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLPFEAENKHVIDFFK 16 1 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 1 4869400.0 1226200.0 1900200.0 1743000.0 True False 1679559.2768090311 1816242.8808788983 1331339.29821181 1.0 1.0813806371452102 0.7926718137279447 20.679651282937257 -6.83142053972053 1.3214569699369934 1.0434444240455962 0.7846699257246776 0.9087005878542893 0.036726045215360076 0.17906657790164615 0.6110317379075553 0.021817380266967057 0.05020929142842746 1.4742782562269075e-07 6.83142053972053 -0.2587744983209186 GLPFGCSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLPFGCSK 8 0 P31942-2;P31942;P55795;P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E5RGH4;H0YAQ2 P31942-2;P55795;P31943 HNRNPH3;HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H3;Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 19970720.0 869920.0 10468000.0 8632800.0 False True 1140473.5443172643 8906215.203944415 7739560.667664945 1.0 7.8092256048570174 6.786269358223626 20.121201550016337 -9.158452731483864 10.010876928561025 0.9999999478379483 7.297747481542097 0.9805958358579558 0.41762013891391403 0.0 0.0 0.4043589607606742 0.13478632025355802 6.943001650795478e-10 9.158452731483864 6.297747533704149 GLPFGCSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLPFGCSK 8 0 P31942-2;P31942;P55795;P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E5RGH4;H0YAQ2 P31942-2;P55795;P31943 HNRNPH3;HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H3;Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 7684780.0 3522600.0 841980.0 3320200.0 False True 3410776.991173754 1178187.004867695 2450540.016135055 1.0 0.34543067691512847 0.7184697277120274 21.701668998785745 -10.72337804528927 6.986503592137271 1.005466027113289 0.5319502023138185 0.6773161821029372 0.15229255476409617 0.013016899595549377 0.0005153876151777558 0.14803338039880456 0.049152210696060426 1.8906970853748602e-11 10.72337804528927 -0.4735158247994704 GLPFGCSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLPFGCSK 8 0 P31942-2;P31942;P55795;P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E5RGH4;H0YAQ2 P31942-2;P55795;P31943 HNRNPH3;HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H3;Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 16446520.0 869920.0 6663300.0 8913300.0 False True 1191552.932704055 6368893.373413519 6808162.115175751 1.0 5.345036043812378 5.713688354344128 20.18441161153923 -9.890052243535733 0.6014228714590995 2.3882193209508504e-18 5.673109318341529 0.9994344352060944 0.05090356387452424 1.1600367547708907 0.28331765891044064 2.3496531514472445 0.06368796499160845 1.2880945907936588e-10 9.890052243535733 5.673109318341529 GLPFQANAQDIINFFAPLKPVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLPFQANAQDIINFFAPLKPVR 22 1 H0Y8R1;F5H5I6;H0YAK1;Q12849-5;Q12849 H0Y8R1 GRSF1 G-rich sequence factor 1 0 1293100000.0 528570000.0 343600000.0 420930000.0 False True 801879333.6431096 282281895.4409467 337733000.9998273 1.0 0.3520254028227409 0.42117683650161425 29.578809916162985 -10.301689285752568 5.670362444375985 1.000067308223837 0.3866011196672631 0.9905581375154802 0.028230954582547492 2.402444617745166e-05 2.9586340175409173e-06 0.027337482015412348 0.009111501412142127 4.9924154007889566e-11 10.301689285752568 -0.6134661885565738 GLPFQANAQDIINFFAPLKPVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLPFQANAQDIINFFAPLKPVR 22 1 H0Y8R1;F5H5I6;H0YAK1;Q12849-5;Q12849 H0Y8R1 GRSF1 G-rich sequence factor 1 0 1017600000.0 528570000.0 340010000.0 149020000.0 False True 684244284.6723759 321088144.60718936 121899889.07432297 1.0 0.46925952002789484 0.17815258644460588 29.349936238255435 -8.775137936572506 0.2670912320429686 1.2536580411231935 3.8336187874598996e-12 0.9990577838436053 0.01044381152042023 0.31179245515012205 0.08233629686549207 0.1813482537519726 0.10690750663771903 1.6782708966775554e-09 8.775137936572506 -1.2536580411193599 GLPLGSAVSSPVLFSPVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLPLGSAVSSPVLFSPVGR 19 0 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 0 2751410.0 0.0 1873800.0 877610.0 False True 0.0 1594236.3440151946 786803.3358295615 0.0 GLPLGSAVSSPVLFSPVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLPLGSAVSSPVLFSPVGR 19 0 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 0 3114500.0 0.0 1693000.0 1421500.0 False True 0.0 1618197.6619976729 1085770.9767114683 0.0 GLPWSCSADEVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLPWSCSADEVQR 13 0 P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;E7EN40;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;D6RDL0;D6RF17;D6R9D3 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 26317000.0 1145000.0 14624000.0 10548000.0 False True 1501106.088195772 12442156.203905517 9456594.143560579 1.0 8.288658810824057 6.299750709109952 20.517594509977265 -9.56880417605297 8.08151489210758 1.0000000013074923 7.294204759967153 0.9303299734121182 0.8119683324150492 0.0 3.058094972047579e-17 0.786184957272582 0.2620616524241939 2.698956120948134e-10 9.56880417605297 6.29420475865966 GLPWSCSADEVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLPWSCSADEVQR 13 0 P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;E7EN40;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;D6RDL0;D6RF17;D6R9D3 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 8495900.0 5888000.0 0.0 2607900.0 False True 5701088.662928256 0.0 1924812.754677011 1.0 0.0 0.33762196458954336 22.442806007661005 -10.528114221064858 6.230604139476524 1.000954039395965 0.16881098229479316 0.8898826399047182 0.13783358986673203 0.0018283938689537392 0.00013847615377049336 0.13358482267443605 0.044485599841819684 2.9640517303671524e-11 10.528114221064858 -0.8321430571011719 GLPWSCSADEVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLPWSCSADEVQR 13 0 P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;E7EN40;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;D6RDL0;D6RF17;D6R9D3 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 27934000.0 1145000.0 13855000.0 12934000.0 False True 1568337.4424615377 13242840.287641898 9879255.58409154 1.0 8.443871790025614 6.299190031824941 20.580804571500156 -10.035690016461796 9.423305462927427 0.9999999947925622 7.371530910925277 0.9216788572374205 0.8755626613744569 9.063130625325987e-08 1.6086848020129515e-08 0.8477599015160691 0.28258663383869287 9.21106789558408e-11 10.035690016461796 6.371530916132715 GLPWSCSVEDVQNFLSDCTIHDGAAGVHFIYTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLPWSCSVEDVQNFLSDCTIHDGAAGVHFIYTR 33 0 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 337210000.0 107480000.0 102560000.0 127170000.0 False True 163055017.8405157 84257366.69506265 102034793.75940904 1.0 0.5167419427562473 0.6257691122343096 27.28078359823641 -9.792445840553233 6.258163191604826 1.0000000118885124 0.5712555274950157 0.9537442619146095 0.044510155554593776 7.377788889937493e-09 1.4879419885442665e-09 0.04309677376282947 0.014365590933180947 1.612702129614818e-10 9.792445840553233 -0.42874448439349666 GLPYK(ub)ATENDIYNFFSPLNPVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLPYKATENDIYNFFSPLNPVR 22 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 24281600.0 11378000.0 2225600.0 10678000.0 True False 11016811.618002327 3114293.6863506767 7881111.466866487 1.0 0.28268557131917177 0.7153713560816577 23.393203417298754 -10.158155881230195 5.623366911256758 1.0000092430369514 0.4990284637021184 0.6412415858892015 0.17664323193744938 2.0469954088437493e-05 3.0645407199710047e-06 0.1710372253062137 0.057011357959477864 6.947748974164702e-11 10.158155881230195 -0.500980779334833 GLPYK(ub)ATENDIYNFFSPLNPVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLPYKATENDIYNFFSPLNPVR 22 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 183164000.0 29859000.0 38545000.0 114760000.0 True False 45298285.98529919 31666343.596540425 92077635.69890508 1.0 0.6990627328993687 2.0326958006487783 25.432953126242612 -6.847438665975713 1.247506638342986 0.839703556483319 2.083397098666697 0.9364774691526622 0.14394320088814092 0.1602983690443844 0.4813712472039 0.09034844135544859 0.20874345056988333 1.4208928668579477e-07 6.847438665975713 1.2436935421833781 up GLPYK(ub)ATENDIYNFFSPLNPVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLPYKATENDIYNFFSPLNPVR 22 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 21183800.0 11378000.0 5558500.0 4247300.0 True False 9461311.130864808 5528555.257224131 5135390.792703625 1.0 0.5843328879851344 0.5427779217566251 23.17360869273303 -13.999999999999998 0.32552037462271877 5.404687480063981 0.5350269012294494 0.9997054687232065 0.0035429041009191024 18.451784493517042 0.18221283692018983 55.51328070673939 0.01354328175640713 1.0000000000000041e-14 13.999999999999998 -4.869660578834531 GLQAEYETQVK(ub)EMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLQAEYETQVKEMR 14 1 E7EQN5;P98171;P98171-2;A0A0B4J1X7;E9PCM6;F8WAR0 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 1 14132900.0 3281600.0 4376900.0 6474400.0 True False 4302209.379059608 3723883.5810225774 5804491.194830173 1.0 0.8655746973050755 1.3491884479362413 22.03664630858545 -6.832559450468883 1.3165834246246002 0.9282920127574308 1.3628818505466953 0.9108699804028438 0.060849885024019966 0.17767515890446015 0.6014426340399395 0.03627999227652681 0.08348355571452863 1.47041711657578e-07 6.832559450468883 0.4345898377892645 GLQAEYETQVK(ub)EMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLQAEYETQVKEMR 14 1 E7EQN5;P98171;P98171-2;A0A0B4J1X7;E9PCM6;F8WAR0 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 1 77673000.0 4182000.0 21194000.0 52297000.0 True False 6344399.745152939 17411765.11052218 41960475.02741058 1.0 2.7444306490656745 6.613781715042149 22.597052243925464 -6.957971010752769 0.46314343158118876 0.8906869201374525 8.624331511262383 0.9996873883149304 0.04147755483634155 0.08043403188102816 0.023870751594502068 0.05283662656584079 0.31954355916938565 1.1016128399740907e-07 6.957971010752769 7.73364459112493 GLQAEYETQVK(ub)EMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLQAEYETQVKEMR 14 1 E7EQN5;P98171;P98171-2;A0A0B4J1X7;E9PCM6;F8WAR0 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 1 61946000.0 4182000.0 14470000.0 43294000.0 True False 5413681.439544205 13664731.77984772 35414936.2339534 1.0 2.5241107982515865 6.541747354261594 22.368178566017914 -6.954316484362203 0.509259287068435 0.9256060045375153 8.316288676826073 0.9994979197851962 0.05237677106799963 0.08179742495923058 0.029137346177185226 0.06040520197455718 0.33156893305438917 1.1109218677236237e-07 6.954316484362203 7.390682672288557 GLQAQIASSGLTVEVDAPK(ub)SQDLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLQAQIASSGLTVEVDAPKSQDLAK 25 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 291537000.0 19081000.0 47996000.0 224460000.0 True False 28947272.007953875 39430738.805540346 180095382.61568707 1.0 1.3621573319484446 6.221497575529813 24.78692405919499 -6.921845190400968 0.810915640241813 0.8997457976991161 7.039385084138017 0.9946784930098125 0.17366681495808003 0.09709823697361167 0.10007466325901612 0.15111278641434295 0.4609631908593532 1.1971672002007622e-07 6.921845190400968 6.139639286438901 up GLQAQIASSGLTVEVDAPK(ub)SQDLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLQAQIASSGLTVEVDAPKSQDLAK 25 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 360505000.0 19081000.0 46044000.0 295380000.0 True False 24700730.642741 43481610.92407109 241623870.8547412 1.0 1.7603370342751128 9.782053589809463 24.55805038128744 -6.925337412438344 0.7841254801699624 0.8546650921195222 11.248985698163903 0.9955397004462909 0.2653274380838675 0.09513210348767516 0.09007950947173089 0.23532788908278504 0.7452986232660164 1.1875792138760626e-07 6.925337412438344 10.394320606044381 up GLQGQPPALFK(ub)PQLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLQGQPPALFKPQLVR 16 1 Q2VPB7 Q2VPB7 AP5B1 AP-5 complex subunit beta-1 1 4243000.0 1163800.0 1481800.0 1597400.0 True False 1525753.070255232 1260721.21601116 1432116.371342783 1.0 0.8262943988703646 0.9386291918804495 20.54109006285692 -10.573564311229537 5.525565493982895 1.0005174646959538 0.8824617953754069 0.5934489375071218 0.04586048720597932 0.00029362105631979354 2.266015698442145e-05 0.04459781971203978 0.014801408599809648 2.6695354275043672e-11 10.573564311229537 -0.1180556693205469 GLQGQPPALFK(ub)PQLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLQGQPPALFKPQLVR 16 1 Q2VPB7 Q2VPB7 AP5B1 AP-5 complex subunit beta-1 1 39716600.0 2787600.0 10047000.0 26882000.0 True False 4228993.00085804 8254034.352430712 21568760.917200822 1.0 1.951772999093641 5.100212015679534 22.011882741978486 -6.949235511497303 0.5671739667567922 0.9602662009037297 6.24405264420573 0.9991399200616228 0.05138552332285837 0.08379417784644703 0.03724400512256943 0.05461694994453048 0.26214796180705063 1.1239952825912044e-07 6.949235511497303 5.283786443302 GLQGQPPALFK(ub)PQLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLQGQPPALFKPQLVR 16 1 Q2VPB7 Q2VPB7 AP5B1 AP-5 complex subunit beta-1 1 10544000.0 1795400.0 1498400.0 7250200.0 True False 1492954.6497059837 1490327.8217908884 8766183.298862778 1.0 0.9982405172751814 5.871700992785785 20.509738911864293 -6.906810672250762 0.9171623361033769 0.8334696166408816 6.46040512694217 0.9896617603682838 0.23354797453738446 0.10656551521589915 0.15048007145566347 0.1882434594687027 0.5088522383197075 1.2393367492758105e-07 6.906810672250762 5.626935510301289 up GLQGQPPALFK(ub)PQLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLQGQPPALFKPQLVR 16 1 Q2VPB7 Q2VPB7 AP5B1 AP-5 complex subunit beta-1 1 35504600.0 2787600.0 12264000.0 20453000.0 True False 3608603.1518109553 11581497.619077573 16730763.865502143 1.0 3.209412931223947 4.636354611923983 21.783009064070935 -8.309156005292762 0.25052572487364366 2.3602016537280325e-17 5.8096379504050315 0.9994093733021207 0.03635574260992963 0.10421843077253173 0.0600590759016762 0.5175263102649493 0.5231349605576285 4.907315661218373e-09 8.309156005292762 5.8096379504050315 GLQPGEEELPDISPPIVIPDDSK(ub)DR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLQPGEEELPDISPPIVIPDDSKDR 25 1 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 214329000.0 57673000.0 80374000.0 76282000.0 True False 75609861.50612645 68382512.49539825 68389070.38861287 1.0 0.9044126140854976 0.9044993473909683 26.17207107614661 -10.223134213275143 6.050944764111585 1.0000019029679121 0.9044559807382326 0.9999993655151712 3.5408723686057034e-05 9.090378515799676e-10 1.16685847322555e-10 3.4285032316630134e-05 1.1428116428678049e-05 5.982266920174713e-11 10.223134213275143 -0.0955459222296795 GLQPGEEELPDISPPIVIPDDSK(ub)DR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLQPGEEELPDISPPIVIPDDSKDR 25 1 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 546270000.0 168310000.0 161670000.0 216290000.0 True False 162967091.178236 226225674.09791222 159637160.43908513 1.0 1.3881678347592934 0.9795668517178787 27.28000542179255 -6.657822639965134 1.9811715557184726 1.2503112222191899 0.9812943780870137 0.2262237045437775 0.16536050757042767 0.4895855552023156 3.6919281545251397 0.06749703344246377 0.18320603027209523 2.1987576325488734e-07 6.657822639965134 -0.2690168441321762 GLQPGEEELPDISPPIVIPDDSK(ub)DR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLQPGEEELPDISPPIVIPDDSKDR 25 1 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 874815300.0 200050000.0 375083400.0 299681900.0 True False 303490475.6140231 308146836.73001987 240449641.10975704 1.0 1.0153426927371476 0.7922806823617065 28.17707600045621 -6.890419409942628 1.0199196495812886 1.011865185070497 0.7729384167984985 0.9811646227234938 0.013961514351778203 0.11880265151738374 0.2198757032238702 0.01042459218110502 0.026027697772434254 1.2870060547489946e-07 6.890419409942628 -0.23892676827199844 GLQPGEEELPDISPPIVIPDDSK(ub)DR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLQPGEEELPDISPPIVIPDDSKDR 25 1 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 318502310.0 57673000.0 83699310.0 177130000.0 True False 78996266.6542221 80001197.7275951 135295542.10686046 1.0 1.0127212476732823 1.712682735996478 26.235281137669503 -6.9108397598726645 0.8899993027471579 0.978899046026883 1.8047840180523502 0.991234534753843 0.03117718116137464 0.10386536479025918 0.13577559303359923 0.025631609280625117 0.07117311261398937 1.227892198710269e-07 6.9108397598726645 0.8258849720254672 GLQPGEEELPDISPPIVIPDDSK(ub)DR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLQPGEEELPDISPPIVIPDDSKDR 25 1 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 519778500.0 168310000.0 188886400.0 162582100.0 True False 139957222.39724502 187868831.47218522 196577265.41530386 1.0 1.3423303796280779 1.404552491455942 27.060410697226825 -12.384026591380833 0.2670766221038678 1.3647831817919493e-12 1.4272492164347859 0.9994502209150237 0.004170467857655313 6.3529962944916045 0.15548957442344744 3.473400074151772 0.026210067246041913 4.1302221231313817e-13 12.384026591380833 1.4272492164334212 GLQPGEEELPDISPPIVIPDDSK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLQPGEEELPDISPPIVIPDDSKDR 25 1 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 697760000.0 200050000.0 262200000.0 235510000.0 True False 258968668.57504 247608339.5076763 192649596.5366648 1.0 0.9561324189143294 0.7439108275016741 27.94820232254866 -6.940543793967303 0.6544861655683181 1.0023616387461924 0.6857543809415793 0.9982342422790444 0.0046989974746266235 0.08751946699869514 0.053486730488895996 0.004593184510950872 0.018222172167823163 1.1467168814228266e-07 6.940543793967303 -0.3166072578046132 GLQSGVDIGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLQSGVDIGVK 11 0 B4DDF4;B4DUT8;Q99439;A0A087X271;H3BVI6;A0A087X1X5 B4DDF4 CNN2 Calponin;Calponin-2 0 21512400.0 5484200.0 8256500.0 7771700.0 False True 7099405.009743727 7797018.516953192 6357330.344376024 1.0 1.0982636581871312 0.8954736820410687 22.75926668894695 -6.7749420326687115 1.5554093842614434 1.0560063509820283 0.894110838019333 0.7491044176883904 0.041474999093710316 0.25853527013256744 1.234983619542313 0.021009178483577452 0.049789975601300565 1.6790281109619348e-07 6.7749420326687115 -0.16189551296269533 GLQVYIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLQVYIR 7 0 G3V1C3;Q9BZZ5-2;Q9BZZ5;Q9BZZ5-3;Q9BZZ5-6;Q9BZZ5-1;Q9BZZ5-5;H0YER7 G3V1C3 API5 Apoptosis inhibitor 5 0 18681300.0 4337600.0 4968700.0 9375000.0 False True 5686635.605378155 4227389.327840904 8404964.93135007 1.0 0.7433902259963406 1.478020663641793 22.43914392994331 -6.812355704991008 1.4047668087698537 0.8605361363917721 1.4915572767963814 0.8658511192397118 0.11149726237196633 0.2036067418036799 0.7914621573251516 0.06240387988913002 0.14419432725451786 1.5404382540206714e-07 6.812355704991008 0.6310211404046093 GLQVYIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLQVYIR 7 0 G3V1C3;Q9BZZ5-2;Q9BZZ5;Q9BZZ5-3;Q9BZZ5-6;Q9BZZ5-1;Q9BZZ5-5;H0YER7 G3V1C3 API5 Apoptosis inhibitor 5 0 11737900.0 5905000.0 2354300.0 3478600.0 False True 5717549.007233585 3294384.2675123075 2567450.3042369117 1.0 0.5761881994092926 0.44904736295022385 22.446965395888512 -13.999999999643775 0.16871647820670146 3.130208769940384 0.33534830940561133 0.999516185967472 0.0051809756884297785 12.07928522944285 0.13004542452584017 8.42041992579018 0.10488025022309735 1.000000000820239e-14 13.999999999643775 -2.794860460534773 GLQVYIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLQVYIR 7 0 G3V1C3;Q9BZZ5-2;Q9BZZ5;Q9BZZ5-3;Q9BZZ5-6;Q9BZZ5-1;Q9BZZ5-5;H0YER7 G3V1C3 API5 Apoptosis inhibitor 5 0 21422200.0 4337600.0 5565600.0 11519000.0 False True 5941327.939232466 5319693.389022005 8798449.44125177 1.0 0.8953711095282906 1.480889378812576 22.5023539914662 -6.8607051431571024 1.182251886021791 0.9431287811291846 1.5096160657620294 0.9544873995540887 0.05439198578049365 0.14607174745083665 0.38756954340291655 0.03587457169011837 0.08380476505090013 1.3781448192945681e-07 6.8607051431571024 0.5664872846328448 GLQVYIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLQVYIR 7 0 G3V1C3;Q9BZZ5-2;Q9BZZ5;Q9BZZ5-3;Q9BZZ5-6;Q9BZZ5-1;Q9BZZ5-5;H0YER7 G3V1C3 API5 Apoptosis inhibitor 5 0 13254500.0 5905000.0 3680300.0 3669200.0 False True 4910269.135854867 3660473.493417649 4436412.755536022 1.0 0.7454730875521284 0.9034968619421004 22.227370671322788 -10.386319938719783 5.499297316126719 1.0000740460664155 0.8244849749458292 0.6219046530890953 0.06451293574735867 5.859275356175923e-05 6.538470134010491e-06 0.06249067933460412 0.020821460480371645 4.108469443483398e-11 10.386319938719783 -0.1755890711205863 GLSCLVSYQDDPLTK(ub)GVDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLSCLVSYQDDPLTKGVDLR 20 1 A0A494C164;P52630-4;P52630;B4DLC8 A0A494C164 STAT2 Signal transducer and activator of transcription 2 1 28260600.0 5114200.0 5122400.0 18024000.0 True False 6620432.715953363 4837333.937048514 14743816.941857457 1.0 0.730667336198722 2.22701711118203 22.658494084960594 -6.860339735656885 1.1840903727798755 0.8537503550821895 2.2999248166130117 0.9540484889794191 0.13960456063880985 0.146447315714513 0.3899829334971868 0.09194744885682236 0.2147050442573643 1.3793048532972785e-07 6.860339735656885 1.446174461530822 up GLSEAAGQTAQMLER ddPTM_RPMI8226_Bortezomib_1h_R1 2 GLSEAAGQTAQMLER 15 0 O95239-2;O95239 O95239-2 KIF4A Chromosome-associated kinesin KIF4A 0 242039100.0 62291200.0 109692600.0 70055300.0 False True 81664366.42883891 93326891.65840587 62806649.573888846 1.0 1.142810453807041 0.7690826773096636 26.283203371828733 -6.803118793347577 1.4430130315024838 1.0784851076016215 0.7635092165449338 0.8411712300855 0.06136637217749038 0.21632825611973763 0.8889391781574707 0.033449682321847196 0.0776532669400463 1.573552388990908e-07 6.803118793347577 -0.3149758910566878 GLSEAAGQTAQMLER ddPTM_RPMI8226_Bortezomib_2h_R1 2 GLSEAAGQTAQMLER 15 0 O95239-2;O95239 O95239-2 KIF4A Chromosome-associated kinesin KIF4A 0 120963500.0 37354300.0 45091200.0 38518000.0 False True 36168508.19321008 63096351.30750159 28428980.284769017 1.0 1.7445107487000717 0.7860147322887372 25.10823075801273 -6.699376067577279 1.832803044987078 1.4626051936011208 0.7888790087983438 0.4146075155830168 0.31430601417221177 0.3968988572895896 2.591524701564251 0.13682329034452867 0.35218277292537364 1.9981308836112852e-07 6.699376067577279 -0.673726184802777 GLSEAAGQTAQMLER ddPTM_RPMI8226_Bortezomib_8h_R1 2 GLSEAAGQTAQMLER 15 0 O95239-2;O95239 O95239-2 KIF4A Chromosome-associated kinesin KIF4A 0 790432000.0 331102000.0 273640000.0 185690000.0 False True 502305940.798572 224806804.0409215 148988290.10918167 1.0 0.4475495624907819 0.2966086562152108 28.90399109703907 -13.999999999999998 0.18206965844404555 3.8848914473733513 0.1792359567661292 0.9994957880150668 0.006789183377438794 12.232218126884117 0.13528253515638486 12.489960618832272 0.11074654299314667 1.0000000000000041e-14 13.999999999999998 -3.705655490607222 GLSEAAGQTAQMLER ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GLSEAAGQTAQMLER 15 0 O95239-2;O95239 O95239-2 KIF4A Chromosome-associated kinesin KIF4A 0 300595500.0 62291200.0 150425500.0 87878800.0 False True 85321939.99638449 143779204.019392 67123637.36069761 1.0 1.6851375393654275 0.7867101634531748 26.346413433351625 -6.702959554425789 1.8213084997270568 1.4242277319600087 0.7893161145821459 0.4312234889994223 0.2890533920173514 0.38937381232314056 2.5133204546221677 0.12654384655258114 0.3241339499550847 1.9817115727742854e-07 6.702959554425789 -0.6349116173778628 GLSEAAGQTAQMLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLSEAAGQTAQMLER 15 0 O95239-2;O95239 O95239-2 KIF4A Chromosome-associated kinesin KIF4A 0 96148200.0 27078000.0 61553000.0 7517200.0 False True 22516556.758793928 61221401.771686174 9089011.764394261 1.0 2.718950434007896 0.403659043510039 24.424482890971912 -6.707893491442457 1.8028527814666033 2.0590479470902507 0.40946159918360864 0.45503250616549307 0.7245999852160906 0.37932320986750967 2.402038409704574 0.3200133101213643 0.8150253400343651 1.9593251293132878e-07 6.707893491442457 -1.6495863479066422 GLSEAAGQTAQMLER ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GLSEAAGQTAQMLER 15 0 O95239-2;O95239 O95239-2 KIF4A Chromosome-associated kinesin KIF4A 0 868471000.0 331102000.0 329153000.0 208216000.0 False True 428618065.9961657 310835346.2012592 170322824.47657526 1.0 0.7252035573415141 0.39737668098688805 28.67511741913152 -6.968783267961295 0.2857563019454586 1.0673950404517125 0.04511622420755051 0.999971275134454 0.0013202462908339875 0.07669951452370553 0.01043646395476926 0.005861514214211433 0.029877889098875378 1.0745255140302136e-07 6.968783267961295 -1.022278816244162 down GLSEDTTEETLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLSEDTTEETLK 12 0 P19338;H7BY16 P19338 NCL Nucleolin 0 48530900.0 2788900.0 25886000.0 19856000.0 False True 3656274.9077460226 22023909.70283769 17801491.592201274 1.0 6.023592388028265 4.868750857460914 21.801943117053703 -9.944824584038162 5.732246115207071 0.9999960238658241 5.446171622748236 0.9518388305665942 0.4714620806236955 20146415.460388996 34951841.67887358 719.6422447794765 0.16139401595886135 1.1354693506910606e-10 9.944824584038162 4.446175598882411 GLSEDTTEETLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLSEDTTEETLK 12 0 P19338;H7BY16 P19338 NCL Nucleolin 0 48160200.0 14873000.0 8826200.0 24461000.0 False True 14400864.756068584 12350547.688024957 18053930.28572966 1.0 0.8576254202248782 1.2536698727152245 23.779652110728644 -6.809461916627964 1.416663749534052 0.9223574618529752 1.2605223369016711 0.8584533241126188 0.0616254767707385 0.20753254542242328 0.8209763933883575 0.034204657540546544 0.07914665954196627 1.5507367652566123e-07 6.809461916627964 0.33816487504869597 GLSEDTTEETLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLSEDTTEETLK 12 0 P19338;H7BY16 P19338 NCL Nucleolin 0 64163900.0 2788900.0 29344000.0 32031000.0 False True 3820031.697188638 28047485.05236839 24465937.499152303 1.0 7.342212650489263 6.404642536646508 21.865153178576595 -9.83054795737725 13.310222816172386 1.0000194403912224 6.873427593567885 0.9812472913273255 0.38276139633087686 0.0 0.0 0.3706071117486818 0.12353570943859615 1.4772433465945655e-10 9.83054795737725 5.873408153176663 GLSEDTTEETLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLSEDTTEETLK 12 0 P19338;H7BY16 P19338 NCL Nucleolin 0 16939650.0 14873000.0 1424100.0 642550.0 False True 12367558.48561716 1416428.0906382818 776904.234184474 1.0 0.11452770506689056 0.06281791471517793 23.56005738616292 -13.391861594067915 0.41028557288122625 9.999993959219118 0.060425555268637327 0.9998400906936541 0.005439117031688027 16.91312042257563 0.2116454855532528 133.45933951591184 0.012871519451279356 4.0563778814062526e-14 13.391861594067915 -9.939568403950481 GLSEDTTEETLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLSEDTTEETLK 12 0 P19338;H7BY16 P19338 NCL Nucleolin 0 13216600.0 3735000.0 6448400.0 3033200.0 False True 4835031.127856906 6089540.87140084 2481188.7232602113 1.0 1.2594625991787538 0.5131691312109465 22.205093747104932 -6.812787051913471 1.4026646523743207 1.1409462185404273 0.49924808889706085 0.8670132173836371 0.11281190487156299 0.2030206869402257 0.7866902828000819 0.0632288758650104 0.1460938660115381 1.5389090302791387e-07 6.812787051913471 -0.6416981296433665 GLSEDTTEETLK(ub)ESFDGSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLSEDTTEETLKESFDGSVR 20 1 P19338;H7BY16 P19338 NCL Nucleolin 1 16475800.0 5823400.0 7313600.0 3338800.0 True False 4842415.120361929 7274200.185164058 4036927.6431330177 1.0 1.502184344868883 0.8336599698274716 22.2072953302836 -6.705696299695959 1.8105130390861444 1.310077905923392 0.835418458240376 0.4446736557083304 0.21176552158473563 0.38378432356371756 2.4495169866899187 0.09317509075513054 0.23795500914328588 1.969262905584736e-07 6.705696299695959 -0.47465944768301604 GLSEDTTEETLK(ub)ESFDGSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLSEDTTEETLKESFDGSVR 20 1 P19338;H7BY16 P19338 NCL Nucleolin 1 25003100.0 6055100.0 0.0 18948000.0 True False 7838446.313865162 0.0 15499658.422898088 1.0 0.0 1.9773891154272838 22.90213629032097 -6.769213555423165 1.5774299158522813 0.42585430323536155 1.988192653154976 0.7275639294494798 0.42136482831177186 0.26769875594976933 1.3144692566008709 0.21056536678814192 0.5016024282073742 1.7013217125404598e-07 6.769213555423165 1.5623383499196146 GLSEDTTEETLKESFDGSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLSEDTTEETLKESFDGSVR 20 1 P19338;H7BY16 P19338 NCL Nucleolin 0 12974600.0 5394900.0 3049800.0 4529900.0 False True 5223641.852518959 4267601.0444969 3343383.2959129536 1.0 0.8169781093317043 0.6400483398954119 22.316624554396206 -6.971538808680525 0.2183280422019928 1.0833345119370403 0.36870561872749963 0.9999920239874603 0.00041499243290280354 0.07580650356647073 0.007216458711292882 0.004964142385024784 0.017996820634022883 1.0677293756700658e-07 6.971538808680525 -0.7146288932095407 GLSEDTTEETLKESFDGSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLSEDTTEETLKESFDGSVR 20 1 P19338;H7BY16 P19338 NCL Nucleolin 0 14027600.0 2045700.0 7186300.0 4795600.0 False True 2802050.5729638184 6868785.504083806 3662978.048482248 1.0 2.4513424455499644 1.3072490853039098 21.41805156388865 -6.5864936003918135 2.2416090056690456 1.9844074637805424 1.3103640219286308 0.0 0.6294673184741907 0.6799307927248138 6.435325991563308 0.23486200980898095 0.7024843784511846 2.5912326045503994e-07 6.5864936003918135 -0.6740434418519117 GLSEDVSISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLSEDVSISK 10 0 Q15029-2;Q15029;Q15029-3;K7EP67 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 7532200.0 1196200.0 3221100.0 3114900.0 False True 1568229.7840172767 2740524.4357494623 2792600.0282306485 1.0 1.7475273481473879 1.7807339566507578 20.580705534372946 -11.206857871987857 0.52601930359601 1.4979868241659033e-10 1.7784806135392868 0.9998614176824313 0.004243480536966452 3.357754971778301 0.2576317687272219 3.9523609009651746 0.0064482789517727465 6.210722542251428e-12 11.206857871987857 1.7784806133894882 GLSEDVSISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLSEDVSISK 10 0 Q15029-2;Q15029;Q15029-3;K7EP67 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 5340060.0 1458400.0 813160.0 3068500.0 False True 1412103.890287798 1137859.0285733792 2264767.7969731996 1.0 0.8057898830244526 1.603825194838619 20.429414802755762 -6.842383778552261 1.271234512574475 0.8966949766623777 1.6313441689694912 0.928485134823183 0.09087049218785655 0.1660299907376653 0.5201554916577852 0.056027461888598425 0.12917403196717311 1.4375276983478243e-07 6.842383778552261 0.7346491923071135 GLSEDVSISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLSEDVSISK 10 0 Q15029-2;Q15029;Q15029-3;K7EP67 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 9937200.0 1196200.0 5154100.0 3586900.0 False True 1638467.4660895115 4926374.81967053 2739748.094524352 1.0 3.006696758787761 1.6721406748851955 20.643915595895837 -10.435319398064511 8.240036480354087 0.9999702256044629 2.3394187168364677 0.5732090317651635 0.5448302397813701 0.0002980765229421177 2.0427453331441558e-05 0.5275411706771943 0.17584320376528662 3.670122852565002e-11 10.435319398064511 1.3394484912320048 GLSEKLPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLSEKLPEK 9 1 O76021;I3L3U9;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 96301000.0 38914000.0 32559000.0 24828000.0 False True 50374940.10961805 30747063.0283388 20309558.75679298 1.0 0.6103642597178649 0.40316789881235593 25.586202882644034 -10.666056673835556 0.12156652167697049 1.9102360899660713 7.412473188497884e-20 0.9998249659082933 0.0032733874806340313 2.641038293632973 0.06713730500501908 0.9490738974585029 0.25314521518824934 2.15746284980017e-11 10.666056673835556 -1.9102360899660713 GLSEKLPEKWESVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLSEKLPEKWESVK 14 2 O76021;I3L3U9;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 55825000.0 16800000.0 18184000.0 20841000.0 False True 22024962.69143143 15471018.080676848 18684573.240988456 1.0 0.7024310686662674 0.8483362039136386 24.392636239546444 -10.115983749970509 4.860743291498292 1.0000113361415102 0.775383636288575 0.7596125588546163 0.05956552203939287 7.317931479482465e-06 1.33077938240534e-06 0.05767697870120972 0.01922468957154943 7.656252538333664e-11 10.115983749970509 -0.22462769985293518 GLSEKLPEKWESVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLSEKLPEKWESVK 14 2 O76021;I3L3U9;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 618360000.0 229610000.0 219540000.0 169210000.0 False True 348335156.7394939 180361371.7261508 135765569.3326225 1.0 0.517781131868455 0.3897555750714999 28.375900847567838 -13.999999999999998 0.1861499279667401 3.551538301067763 0.2942639920491958 0.9994919941822623 0.005922047549645629 12.290526649705297 0.13681222856194236 11.360914406869778 0.09081731611912419 1.0000000000000041e-14 13.999999999999998 -3.2572743090185674 GLSEKLPEKWESVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLSEKLPEKWESVK 14 2 O76021;I3L3U9;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 69971000.0 16800000.0 33590000.0 19581000.0 False True 23011414.00292913 32105882.732724063 14956371.083353687 1.0 1.3952155538393816 0.6499544565775005 24.455846301069336 -6.76259299268486 1.6024143509059399 1.2288131989744282 0.6468464578672412 0.7016165571367297 0.16629757750420152 0.27856076404754176 1.410230951952488 0.08185602205110053 0.19623583714160778 1.7274560518473585e-07 6.76259299268486 -0.581966741107187 GLSEKLPEKWESVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLSEKLPEKWESVK 14 2 O76021;I3L3U9;O76021-2 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 716820000.0 229610000.0 226450000.0 260760000.0 False True 297234671.2897519 213847858.43445182 213304355.62354347 1.0 0.7194579875440826 0.7176294565434763 28.147027169660287 GLSFLFPLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLSFLFPLLK 10 0 D3DQV9;P78344;H0Y3P2;P78344-2 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 64027000.0 19952000.0 21756000.0 22319000.0 False True 26157265.21544286 18510089.60422377 20009643.97896558 1.0 0.7076462104033601 0.7649746184915457 24.64070837682263 -10.706904990384283 6.78554091991047 1.0027057321144708 0.736310414447454 0.9657637644423847 0.02340422459701648 0.0009661055292236871 4.172998842168339e-05 0.0228527819728074 0.007553681007928568 1.963789843682822e-11 10.706904990384283 -0.26639531766701674 GLSFLFPLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLSFLFPLLK 10 0 D3DQV9;P78344;H0Y3P2;P78344-2 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 71060000.0 35251000.0 0.0 35809000.0 False True 34131976.30042182 0.0 26429548.653027 1.0 0.0 0.774333968253118 25.02462061560324 -10.866164923053926 9.467651129378568 1.033131287821116 0.3871669845455284 0.4550865217741301 0.3161205187874346 0.15314948624739472 0.002164923420028099 0.2120403867264191 0.10202745872151515 1.360927772865931e-11 10.866164923053926 -0.6459643032755877 GLSFLFPLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLSFLFPLLK 10 0 D3DQV9;P78344;H0Y3P2;P78344-2 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 113568000.0 19952000.0 33834000.0 59782000.0 False True 27328793.582526315 32339102.005923957 45662722.848937646 1.0 1.1833344164376567 1.6708649326596625 24.70391843834552 -6.9541251818623175 0.5115557979045251 0.991140966492219 1.8845038973434227 0.9994865110883462 0.006415334578875296 0.08187035601035623 0.029425172926057168 0.0073695202679048165 0.040241382306851044 1.1114113258060333e-07 6.9541251818623175 0.8933629308512037 GLSIHTFHGNFFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLSIHTFHGNFFVR 14 0 O95486 O95486 SEC24A Protein transport protein Sec24A 0 7388700.0 2027200.0 1765600.0 3595900.0 False True 1962847.6456331762 2470613.2874823664 2654025.9153123405 1.0 1.2586882598753073 1.3521303710029944 20.904516765857437 -13.26070098059 0.1498901856617569 1.0073301183599202e-09 1.45876339705023 0.9995713145273499 0.0030837459364022064 9.155454410266493 0.11572837947305005 2.7593637666364246 0.09238631967432083 5.486545932675742e-14 13.26070098059 1.4587633960428998 GLSIHTFHGNFFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLSIHTFHGNFFVR 14 0 O95486 O95486 SEC24A Protein transport protein Sec24A 0 6378330.0 918830.0 1639100.0 3820400.0 False True 1258546.2814471067 1566679.1422211388 2918100.2036078004 1.0 1.2448323635899456 2.3186276473301395 20.263326840083312 -6.942765057872715 0.6333160815847411 0.9882815070632722 2.633380214302352 0.9985041195347905 0.022149685062489457 0.08652750561610184 0.049032829371567464 0.022042936054705725 0.09135325054544988 1.1408668002023323e-07 6.942765057872715 1.64509870723908 up GLSIHTFHGNFFVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLSIHTFHGNFFVR 14 0 O95486 O95486 SEC24A Protein transport protein Sec24A 0 6158100.0 2027200.0 1394200.0 2736700.0 False True 1685706.6201871247 1386689.1678729672 3308931.3169288803 1.0 0.8226159589496276 1.962934283642765 20.684922041291713 -6.867170342189811 1.1490384406832421 0.9012157546531772 2.0261995817219365 0.9617723038857763 0.09795556962434279 0.1395926100893737 0.34624526995478766 0.06627111582466715 0.15616494458093041 1.3577807833227052e-07 6.867170342189811 1.1249838270687593 GLSIHTFHGNFFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLSIHTFHGNFFVR 14 0 O95486 O95486 SEC24A Protein transport protein Sec24A 0 36082100.0 10010000.0 16276000.0 9796100.0 False True 12958142.326599102 15370226.292246137 8013310.316474143 1.0 1.1861442716750967 0.6183996219909754 23.62735557315169 -6.818398255797205 1.3789640219449475 1.1004937390601144 0.6064423965895949 0.8806252808359847 0.08164832112495143 0.19556896708270852 0.7311861754175445 0.04653585614463006 0.10729711805157882 1.519153799623321e-07 6.818398255797205 -0.4940513424705195 GLSLVDK(ub)ENTPPALSGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLSLVDKENTPPALSGTR 18 1 P31350;P31350-2;A0A286YFD6 P31350 RRM2 Ribonucleoside-diphosphate reductase subunit M2 1 5049800.0 1548900.0 1345900.0 2155000.0 True False 2030622.8995689359 1145096.96627711 1932021.2722196667 1.0 0.5639141400996674 0.951442669453693 20.953490915588112 -10.279850714793527 8.1219501764328 1.0000003430642836 0.7576784047766802 0.3426819203841073 0.15820785961475592 9.82787529267819e-07 8.712371983393725e-08 0.15318431822465642 0.05106136712725588 5.249878895673657e-11 10.279850714793527 -0.2423219382876034 GLSLVDK(ub)ENTPPALSGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLSLVDKENTPPALSGTR 18 1 P31350;P31350-2;A0A286YFD6 P31350 RRM2 Ribonucleoside-diphosphate reductase subunit M2 1 4624600.0 1548900.0 1008700.0 2067000.0 True False 2121570.1874486255 964132.2986751633 1578817.1712012682 1.0 0.45444280108150326 0.7441739050358426 21.016700977111004 -10.054172031124763 5.220654299304477 1.0000046234848279 0.5993083530577953 0.7183233193078973 0.11828222788665438 6.365319667973374e-06 1.1532910002926505e-06 0.11452759522123244 0.038175424895998934 8.827301673448528e-11 10.054172031124763 -0.4006962704270326 GLSLVDK(ub)ENTPPALSGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLSLVDKENTPPALSGTR 18 1 P31350;P31350-2;A0A286YFD6 P31350 RRM2 Ribonucleoside-diphosphate reductase subunit M2 1 30448500.0 0.0 6462500.0 23986000.0 True False 0.0 6102856.194005945 19620794.117143434 0.0 GLSMAKEGVVAAAEKTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLSMAKEGVVAAAEKTK 17 2 G4Y816;Q16143 G4Y816 SNCB Beta-synuclein 0 13001000.0 2941800.0 3444200.0 6615000.0 False True 3856728.288431724 2930338.7853864506 5930543.2555606 1.0 0.759799126678438 1.5377135260861634 21.87894607911244 -6.823773114074873 1.355337029484513 0.8710025779304184 1.5561306850993213 0.8928752684500866 0.10644817970824452 0.18861821191609374 0.67973862784479 0.06170002858357403 0.1420954375297583 1.500468511764218e-07 6.823773114074873 0.6851281071689029 GLSMAKEGVVAAAEKTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLSMAKEGVVAAAEKTK 17 2 G4Y816;Q16143 G4Y816 SNCB Beta-synuclein 0 22364200.0 6271300.0 3271900.0 12821000.0 False True 6072221.014236068 4578386.7327330895 9462795.478244547 1.0 0.75398881595371 1.558374679719236 22.533792871661788 -6.824616444479976 1.3517108480541453 0.8679821066188845 1.577746247701196 0.894685814030302 0.10921487716489833 0.18755136018059196 0.6720363074038442 0.0634699426299991 0.14614478144683196 1.4975576690705225e-07 6.824616444479976 0.7097641410823116 GLSMAKEGVVAAAEKTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLSMAKEGVVAAAEKTK 17 2 G4Y816;Q16143 G4Y816 SNCB Beta-synuclein 0 15180600.0 2941800.0 4586000.0 7652800.0 False True 4029462.9591557677 4383375.3561260095 5845366.2543633655 1.0 1.0878311577889257 1.450656405981222 21.94215614063533 -6.944135663614928 0.6199011367038395 0.9960287488188593 1.5616771974681494 0.9986568971094373 0.007148754008352938 0.08592965932482942 0.04639219110706307 0.0071999943408162246 0.030704824599140625 1.1372719727036949e-07 6.944135663614928 0.5656484486492901 GLSMHTFHGNFFVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLSMHTFHGNFFVR 14 0 O95487-2;O95487;O95487-3 O95487-2 SEC24B Protein transport protein Sec24B 0 14780900.0 2546100.0 3953800.0 8281000.0 False True 3862619.844843113 3248213.4988196003 6644256.7203087555 1.0 0.8409353312768298 1.72014254241958 21.881148265287088 -6.8600668821599555 1.1852736081605624 0.9136726138043192 1.762797448537463 0.9537299975432876 0.08228239252172696 0.14673938257343844 0.39166727702112636 0.05413996700922461 0.12639877950792505 1.380171699220561e-07 6.8600668821599555 0.8491248347331437 GLSMHTFHGNFFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLSMHTFHGNFFVR 14 0 O95487-2;O95487;O95487-3 O95487-2 SEC24B Protein transport protein Sec24B 0 14016700.0 2546100.0 3470300.0 8000300.0 False True 3295976.641134266 3277174.75436113 6544327.490010106 1.0 0.994295503633586 1.9855503247007127 21.652274587379537 -6.905602851024189 0.9251459247896434 0.964879246164926 2.1023045757641374 0.989153954550661 0.04852535731725294 0.10739877395740213 0.15506627530084988 0.03888401289205039 0.10433445991505867 1.2427882798498545e-07 6.905602851024189 1.1374253295992114 GLSNLFLSCPIPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLSNLFLSCPIPK 13 0 Q9Y570-2;Q9Y570;Q9Y570-4;Q9Y570-3 Q9Y570-2 PPME1 Protein phosphatase methylesterase 1 0 46128000.0 18698000.0 16560000.0 10870000.0 False True 24513259.071689565 14089312.550374424 9745276.672402684 1.0 0.5747629276535576 0.3975512453852998 24.547058969468598 -13.999999999999998 0.12003663562915132 3.026688942777714 0.11485032117191521 0.9996927620281788 0.004431143768651991 11.963618206629095 0.10663208881566816 5.78381122663497 0.25086576994644344 1.0000000000000041e-14 13.999999999999998 -2.9118386216057988 GLSNLFLSCPIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLSNLFLSCPIPK 13 0 Q9Y570-2;Q9Y570;Q9Y570-4;Q9Y570-3 Q9Y570-2 PPME1 Protein phosphatase methylesterase 1 0 61757000.0 18698000.0 18095000.0 24964000.0 False True 25611155.89445052 17295503.06783691 19068017.34971866 1.0 0.675311303367785 0.7445199829442434 24.61026903099149 -10.08218568219422 5.0606650760191245 1.0000065731456926 0.7099156431550261 0.9590571313194041 0.02825432512578769 2.095454495943351e-06 3.800674824410391e-07 0.027357752551406555 0.009119044222049412 8.27588253487141e-11 10.08218568219422 -0.29009092999066655 GLSNLFLSCPIPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLSNLFLSCPIPK 13 0 Q9Y570-2;Q9Y570;Q9Y570-4;Q9Y570-3 Q9Y570-2 PPME1 Protein phosphatase methylesterase 1 0 29060400.0 18178000.0 3814000.0 7068400.0 False True 15115812.421942383 3793453.2249802714 8546369.759411003 1.0 0.2509592682874013 0.5653926842201972 23.849555185063316 -10.512002072797182 6.26019474195092 1.0005214714453803 0.40817597625724833 0.8252825994873454 0.12836690451927676 0.0009350420047965202 7.288850175792771e-05 0.12439317144627648 0.041430240283946346 3.076082133205805e-11 10.512002072797182 -0.592345495188132 GLSQSALPYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLSQSALPYR 10 0 P62277;J3KMX5;E9PS50 P62277 RPS13 40S ribosomal protein S13 0 9322400.0 3708400.0 1441800.0 4172200.0 False True 3590678.8718755282 2017518.2588876737 3079375.6566829365 1.0 0.5618765506127977 0.8576026335305442 21.77582520236881 -9.928485063735637 5.462277096809821 1.0000004072642659 0.7097395920706856 0.5622680031165178 0.12072966780021031 5.987019244463178e-07 1.1751268317493017e-07 0.11689616279956726 0.0389653327314452 1.1790030708433236e-10 9.928485063735637 -0.29026081519358027 GLSSDNKPMVNLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLSSDNKPMVNLDK 14 1 P82979;F8VZQ9;H0YHG0 P82979 SARNP SAP domain-containing ribonucleoprotein 0 4566310.0 1594000.0 448010.0 2524300.0 False True 1543399.342511487 626902.7293412864 1863110.1026232527 1.0 0.40618309991059265 1.2071471402803102 20.557679965594463 -6.708148386592748 1.8018970011406557 0.634246716967048 1.205158144272614 0.45628546827435856 0.25030448814873896 0.3787969909100771 2.39631452347765 0.1105956621740077 0.2815879597491923 1.958175503971924e-07 6.708148386592748 0.570911427305566 GLSSLLCNFTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLSSLLCNFTK 11 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 27280600.0 6664800.0 9823800.0 10792000.0 False True 8737617.342015015 8358127.332872472 9675347.364173863 1.0 0.9565682503263495 1.1073210219048795 23.0588084946456 -6.8296798240469325 1.3295442459682971 0.9767885384660747 1.1113453270437854 0.905192806600464 0.019509065182429005 0.18120910727809939 0.626610640437478 0.011522044482896695 0.02651300066244137 1.4801992368156298e-07 6.8296798240469325 0.1345567885777107 GLSSLLCNFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLSSLLCNFTK 11 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 42745800.0 6664800.0 17201000.0 18880000.0 False True 9128956.669447746 16441002.943899585 14420932.845805477 1.0 1.8009728317501346 1.5796912361374882 23.12201855616849 -10.133313895811026 4.693714807278925 0.9999418244411987 1.6903320339478944 0.9284523428468786 0.09033783314867216 63090352.18121301 4.917432154277836 40250.77650539077 0.03092504312796966 7.356751800051407e-11 10.133313895811026 0.6903902095066957 GLSVHTDMASVTK(ub)AMAAPESGLEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLSVHTDMASVTKAMAAPESGLEVR 25 1 I3L2N2;O14641;I3L0Z8 I3L2N2 DVL2 Segment polarity protein dishevelled homolog DVL-2 1 83478500.0 2864500.0 12326000.0 68288000.0 True False 4345655.923001094 10126328.99652244 54790846.868306346 1.0 2.3302187692598624 12.608188001793753 22.05114251976808 -6.930749366479063 0.7406174253087681 0.8479685731458766 14.759024484673272 0.9966834489189859 0.2987238191657774 0.09225060396026191 0.0757881966426174 0.273374743731189 0.9261765675408234 1.1728720406027507e-07 6.930749366479063 13.911055911527395 GLSVHTDMASVTK(ub)AMAAPESGLEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLSVHTDMASVTKAMAAPESGLEVR 25 1 I3L2N2;O14641;I3L0Z8 I3L2N2 DVL2 Segment polarity protein dishevelled homolog DVL-2 1 54562500.0 2864500.0 11681000.0 40017000.0 True False 3708151.7177365753 11030942.08157575 32734316.609093964 1.0 2.974781756855662 8.827663779915326 21.82226884186053 -6.951723185729757 0.5395944503994538 0.9135998925615363 11.158944197188497 0.9993296662866163 0.08605563366674014 0.08280109321844474 0.03315515567027897 0.09470421992844756 0.48467027809133234 1.1175753503915641e-07 6.951723185729757 10.245344304626961 GLTAVSNNAGVDNFGLGLLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLTAVSNNAGVDNFGLGLLLR 21 0 P55809 P55809 OXCT1 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 0 60163000.0 10981000.0 26674000.0 22508000.0 False True 16658979.818633279 21913816.295086753 18059283.93439316 1.0 1.3154356709512232 1.084057014955599 23.989796718236494 -10.188341108160682 3.881858540878317 0.9998599651080121 1.1997463427959012 0.49841687188317363 0.09445994102344099 66851729.40845859 101884674.80727763 110594.12432418541 0.03456879376056966 6.481251762573458e-11 10.188341108160682 0.19988637768788908 GLTAVSNNAGVDNFGLGLLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLTAVSNNAGVDNFGLGLLLR 21 0 P55809 P55809 OXCT1 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 0 43711000.0 10981000.0 15934000.0 16796000.0 False True 14215120.967870604 15047258.8928883 13739300.341513416 1.0 1.0585389267455771 0.9665271489822246 23.760923040328944 -6.734800499036252 1.7055248674397163 1.035038334570892 0.9665299738136183 0.5814565244939376 0.02460053197308568 0.32731349180575653 1.867264974780417 0.011420154035278487 0.028187830127827593 1.8416177873693777e-07 6.734800499036252 -0.06850836075727373 GLTEALAQSSASLNSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLTEALAQSSASLNSTR 17 0 Q5TZA2;Q5TZA2-2 Q5TZA2 CROCC Rootletin 0 6070000.0 2246500.0 3823500.0 0.0 False True 2945183.25513695 3253048.7038862705 0.0 1.0 1.104531848132827 0.0 21.4899259735164 -6.957855024386798 1.190224098549045 1.0609418618593782 7.920104895849179e-20 0.9743123561231506 0.07979627827865304 0.10450865111441217 0.2936319639968478 0.05588422763420735 0.10552882630021375 1.1019070853278904e-07 6.957855024386798 -1.0609418618593782 down GLTEALAQSSASLNSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLTEALAQSSASLNSTR 17 0 Q5TZA2;Q5TZA2-2 Q5TZA2 CROCC Rootletin 0 10141900.0 2246500.0 5221100.0 2674300.0 False True 3077091.7593797822 4990414.53813116 2042685.4189373748 1.0 1.6217958151293566 0.6638363684510656 21.55313603503929 -6.7315240568295875 1.7177831689778504 1.3735642229501104 0.6642598753968438 0.5662418891995326 0.2613586411307976 0.3334024831289986 1.928055144807789 0.12054057151243425 0.2985859800293056 1.8555640215196623e-07 6.7315240568295875 -0.7093043475532665 GLTEALAQSSASLNSTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLTEALAQSSASLNSTR 17 0 Q5TZA2;Q5TZA2-2 Q5TZA2 CROCC Rootletin 0 20291000.0 11845000.0 8446000.0 0.0 False True 15333585.999856763 7975972.675369299 0.0 1.0 0.5201635596163745 0.0 23.870191797555925 -7.867709372317545 0.6055991067848391 1.0075703036291 5.6017023010800664e-18 0.9885343545019759 0.0437261568116495 0.11428989208377012 0.15883390533857786 0.04403713463354728 0.0775103529772541 1.3560966017975893e-08 7.867709372317545 -1.0075703036291 down GLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSR 33 0 P00441;H7BYH4 P00441 SOD1 Superoxide dismutase [Cu-Zn] 0 1124151800.0 270057000.0 530518000.0 323576800.0 False True 354047342.2357085 451366782.34296674 290096176.7038376 1.0 1.2748769119200658 0.8193711464460164 28.399367045514534 -6.743313396281259 1.6742719611965249 1.1629255670683285 0.8188937957764327 0.6197352619076 0.11548834394048849 0.3119106543763504 1.7179387260685814 0.05453745239272179 0.13336156065786878 1.805870500535554e-07 6.743313396281259 -0.34403177129189577 GLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSR 33 0 P00441;H7BYH4 P00441 SOD1 Superoxide dismutase [Cu-Zn] 0 317909900.0 149479000.0 104736900.0 63694000.0 False True 144733870.96566767 146558890.36571813 47010630.62095847 1.0 1.0126094837916921 0.32480738825889527 27.1088273434146 -6.902727828120283 0.9438930236755408 1.0264955668761868 0.2484827066679749 0.9878743844003988 0.03538062959654681 0.10942417703478538 0.16632506348674475 0.027963042552578084 0.07380048360342327 1.2510428117647558e-07 6.902727828120283 -0.7780128602082119 down GLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSR 33 0 P00441;H7BYH4 P00441 SOD1 Superoxide dismutase [Cu-Zn] 0 3557014000.0 1022425000.0 1789615000.0 744974000.0 False True 1551093474.2797663 1470244220.9241838 597729562.366296 1.0 0.9478759631858267 0.38536011676784687 30.530638484793776 -6.9249825639798255 0.7868860297853352 1.0103282402897267 0.2833681036228603 0.9954568616162682 0.018756386009483376 0.09532806728535848 0.0910656227581116 0.016602820711002837 0.05237212877326141 1.1885499442873856e-07 6.9249825639798255 -0.7269601366668663 down GLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSR 33 0 P00441;H7BYH4 P00441 SOD1 Superoxide dismutase [Cu-Zn] 0 2842997500.0 270057000.0 1640421100.0 932519400.0 False True 369904370.91601413 1567941871.6548424 712277523.5598959 1.0 4.2387762755332234 1.9255720655477648 28.462577107037426 -9.881519939813966 6.892045700736892 0.999999959271427 3.0821741705405197 0.519300400922228 0.9443616642204659 5.901523549718751e-07 9.489366411538393e-08 0.914374276830692 0.3047914165268686 1.3136511797532975e-10 9.881519939813966 2.0821742112690926 GLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSR 33 0 P00441;H7BYH4 P00441 SOD1 Superoxide dismutase [Cu-Zn] 0 316698800.0 149479000.0 76298000.0 90921800.0 False True 124298411.5424976 75886967.53003272 109933128.00509529 1.0 0.6105224241267716 0.8844290658333085 26.889232618848876 -10.087437403033931 5.748403119918905 1.00000143392164 0.7474757449800109 0.5312397613241913 0.11182191822349477 2.054987557497627e-06 3.261343407061565e-07 0.10827172141006082 0.03609036891836517 8.176408799890545e-11 10.087437403033931 -0.2525256889416292 GLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLTEGLHGFHVHEFGDNTAGCTSAGPHFNPLSR 33 0 P00441;H7BYH4 P00441 SOD1 Superoxide dismutase [Cu-Zn] 0 3162147900.0 1022425000.0 1148538000.0 991184900.0 False True 1323549317.5097978 1084620850.653957 810799418.6159178 1.0 0.8194789845040495 0.6125947918143335 30.301764806886226 -6.9693445649633965 0.27339651021990186 1.049357827078243 0.3764680587852926 0.9999768046681611 0.0007622766299193494 0.07651604637294852 0.009789250463508748 0.0039727545040294816 0.0191529434658725 1.0731376576536993e-07 6.9693445649633965 -0.6728897682929504 GLTELQQQFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLTELQQQFAK 11 0 X6R3R3;H0YDM2;O94964-4;O94964;O94964-2 X6R3R3 SOGA1 Protein SOGA1;N-terminal form;C-terminal 80 kDa form 0 54815000.0 14753000.0 22380000.0 17682000.0 False True 19341325.86825522 19040991.236556716 15852436.25772072 1.0 0.9844718695220661 0.8196147650735367 24.205183360680486 -6.925237576758371 0.784894223361025 1.0029980377460297 0.7895389339113721 0.9955166608070168 0.0054651517090621325 0.0951871446667504 0.0903536610295258 0.00484453428461279 0.015325836587533155 1.1878522461431965e-07 6.925237576758371 -0.2134591038346576 GLTELQQQFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLTELQQQFAK 11 0 X6R3R3;H0YDM2;O94964-4;O94964;O94964-2 X6R3R3 SOGA1 Protein SOGA1;N-terminal form;C-terminal 80 kDa form 0 61358000.0 21117000.0 19149000.0 21092000.0 False True 20446652.3938614 26795295.56071579 15567372.453563206 1.0 1.3104979262405034 0.7613653400904357 24.28536132302101 -6.75329784001872 1.6375170871612745 1.1818511685592654 0.7599864668152853 0.6630601142050314 0.13050102087309642 0.29434209879448897 1.553816887634541 0.06292758955310025 0.1522533695214896 1.7648270836496496e-07 6.75329784001872 -0.42186470174398016 GLTELQQQFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLTELQQQFAK 11 0 X6R3R3;H0YDM2;O94964-4;O94964;O94964-2 X6R3R3 SOGA1 Protein SOGA1;N-terminal form;C-terminal 80 kDa form 0 153481000.0 67114000.0 53733000.0 32634000.0 False True 101816844.69062513 44143926.33215478 26183875.596009683 1.0 0.43356211308932235 0.25716644112838616 26.60140102131079 -13.999999999999998 0.16334580493548959 3.810257279358724 0.09000670851008925 0.9995279707110408 0.006884807290479689 12.033649842693814 0.12782570156522924 10.712598302032657 0.15301654553916705 1.0000000000000041e-14 13.999999999999998 -3.720250570848635 GLTELQQQFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLTELQQQFAK 11 0 X6R3R3;H0YDM2;O94964-4;O94964;O94964-2 X6R3R3 SOGA1 Protein SOGA1;N-terminal form;C-terminal 80 kDa form 0 61739000.0 14753000.0 22786000.0 24200000.0 False True 20207582.78483412 21779239.176774345 18484458.414644733 1.0 1.0777755760634449 0.9147288229108431 24.268393422203378 -6.777028826719875 1.5478033227327417 1.0442092713350464 0.9135636996586152 0.7566052934305335 0.032850728925464236 0.2552239048363925 1.2075438403545957 0.016721394980885537 0.03954874910098235 1.6709796977222318e-07 6.777028826719875 -0.1306455716764312 GLTELQQQFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLTELQQQFAK 11 0 X6R3R3;H0YDM2;O94964-4;O94964;O94964-2 X6R3R3 SOGA1 Protein SOGA1;N-terminal form;C-terminal 80 kDa form 0 51672000.0 21117000.0 22167000.0 8388000.0 False True 17559721.14171841 22047581.971195 10141892.018269975 1.0 1.2555769988177274 0.5775656649908212 24.065766598455287 -6.804581809083651 1.4371138913976231 1.1402046579432092 0.5671106482282329 0.8452257217607844 0.1099894039283081 0.21428262636946793 0.8731721728345799 0.06019657436869062 0.13962420272201143 1.568260452905884e-07 6.804581809083651 -0.5730940097149764 GLTELQQQFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLTELQQQFAK 11 0 X6R3R3;H0YDM2;O94964-4;O94964;O94964-2 X6R3R3 SOGA1 Protein SOGA1;N-terminal form;C-terminal 80 kDa form 0 151615000.0 67114000.0 48034000.0 36467000.0 False True 86880396.01472254 45360865.6747205 29830380.18301795 1.0 0.5221070316833473 0.3433499563924981 26.372527343403238 -13.999999943883756 0.13650444266868264 3.2767622564529937 0.11252751181923945 0.9996172309545299 0.005423140619350583 11.93205675691066 0.11548838543947909 7.251820067791964 0.20590588042206792 1.0000001292124355e-14 13.999999943883756 -3.164234744633754 GLTELVEFYQQNSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLTELVEFYQQNSLK 15 0 A0A0A0MR07;P15498;F5H5P4;Q96D37;P15498-2 A0A0A0MR07 VAV1 Proto-oncogene vav 0 103016500.0 20860000.0 45553000.0 36603500.0 False True 27347662.008527346 38756669.96420329 32816120.945564996 1.0 1.4171840339447836 1.1999607474793463 24.704914164400087 -10.17744051482782 4.450771999972744 0.9999326514515794 1.3085723907196227 0.7290372396116422 0.08868103537410664 62202969.03816611 5.476565968104913 42933.37226001383 0.030357877182006988 6.645986965385216e-11 10.17744051482782 0.30863973926804333 GLTELVEFYQQNSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLTELVEFYQQNSLK 15 0 A0A0A0MR07;P15498;F5H5P4;Q96D37;P15498-2 A0A0A0MR07 VAV1 Proto-oncogene vav 0 167653000.0 62517900.0 40456100.0 64679000.0 False True 60533303.485068254 56610431.70577442 47737629.5715918 1.0 0.9351948175063419 0.7886176174635379 25.851225749630668 -6.957569643702002 0.46843042886497405 1.0039311468636638 0.7138881946401904 0.9996691662793408 0.0016082947919186731 0.08058097313405559 0.024427704960391105 0.002020743144676622 0.012099233428070675 1.1026314010934486e-07 6.957569643702002 -0.2900429522234734 GLTELVEFYQQNSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLTELVEFYQQNSLK 15 0 A0A0A0MR07;P15498;F5H5P4;Q96D37;P15498-2 A0A0A0MR07 VAV1 Proto-oncogene vav 0 690128800.0 316580000.0 218610000.0 154938800.0 False True 480275005.09816206 179597337.49227408 124315078.26791139 1.0 0.373946875406449 0.25884144906209094 28.83928548760084 -13.999999999999998 0.23817837702286082 5.107599178750131 0.20706026191361795 0.9995219879708502 0.007120127159387677 13.55984278599398 0.1544740145356912 26.463599713412737 0.05685338030507014 1.0000000000000041e-14 13.999999999999998 -4.9005389168365125 GLTELVEFYQQNSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLTELVEFYQQNSLK 15 0 A0A0A0MR07;P15498;F5H5P4;Q96D37;P15498-2 A0A0A0MR07 VAV1 Proto-oncogene vav 0 107423910.0 20860000.0 43854910.0 42709000.0 False True 28572505.720303655 41917255.06740597 32622013.819465376 1.0 1.4670486193172592 1.1417274403163087 24.76812422592298 -10.14206871187245 8.614925793456813 0.9999999876316029 1.304388029816784 0.5385888080310857 0.1328118151788264 3.136346476737675e-08 3.336431538674236e-09 0.12859449188230349 0.042864829030597684 7.20993398236131e-11 10.14206871187245 0.3043880421851811 GLTELVEFYQQNSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLTELVEFYQQNSLK 15 0 A0A0A0MR07;P15498;F5H5P4;Q96D37;P15498-2 A0A0A0MR07 VAV1 Proto-oncogene vav 0 157979900.0 62517900.0 63859000.0 31603000.0 False True 51986403.86256741 63514978.891980864 38211041.18423773 1.0 1.2217613485997356 0.7350198964570318 25.631631025064944 -6.782830903749352 1.5247166935502436 1.1251085994757029 0.7308092044142368 0.7772847810551443 0.09390042785243437 0.2462204696932086 1.1307396618173753 0.04849577934247727 0.1141678998540001 1.648804242518918e-07 6.782830903749352 -0.39429939506146605 GLTELVEFYQQNSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLTELVEFYQQNSLK 15 0 A0A0A0MR07;P15498;F5H5P4;Q96D37;P15498-2 A0A0A0MR07 VAV1 Proto-oncogene vav 0 609510000.0 316580000.0 169500000.0 123430000.0 False True 409819050.7247492 160067175.99752536 100967006.49874978 1.0 0.39058012484888815 0.2463697241994815 28.61041180969329 -13.999999999999996 0.20246229008669694 4.419878702503312 0.15495276476098407 0.9994872011026583 0.007396413858784508 12.580651564925809 0.14266310841021979 17.055630868777914 0.09016786656467385 1.0000000000000082e-14 13.999999999999996 -4.264925937742328 GLTELVEFYQQNSLKDCFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLTELVEFYQQNSLKDCFK 19 1 A0A0A0MR07;P15498;F5H5P4;Q96D37;P15498-2 A0A0A0MR07 VAV1 Proto-oncogene vav 0 50346000.0 17016000.0 15205000.0 18125000.0 False True 25814516.03623202 12491548.95279278 14542585.80553029 1.0 0.4838963060651704 0.5633491553790515 24.621679215296556 -10.715044237894414 6.8500981611652945 1.0053207895403837 0.5236227307222052 0.979563304400657 0.03243648990487486 0.0026465614871482987 0.00011009361835908467 0.03153500348087893 0.010468832100917107 1.9273285825801565e-11 10.715044237894414 -0.4816980588181785 GLTELVEFYQQNSLKDCFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLTELVEFYQQNSLKDCFK 19 1 A0A0A0MR07;P15498;F5H5P4;Q96D37;P15498-2 A0A0A0MR07 VAV1 Proto-oncogene vav 0 41211100.0 17016000.0 9778100.0 14417000.0 False True 22027547.43550552 9233940.139359295 11793253.930912057 1.0 0.41919964836736173 0.5353866092192759 24.392805537389005 -9.439818298753773 12.127585027811584 1.0000004697417413 0.477293111681384 0.964267994878385 0.04743312814276314 0.0 0.0 0.045926928838513445 0.015308976279504479 3.6322999208548606e-10 9.439818298753773 -0.5227073580603573 GLTEQEVETILDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLTEQEVETILDK 13 0 Q13618;Q13618-3;Q13618-2 Q13618 CUL3 Cullin-3 0 16718300.0 4563400.0 7031800.0 5123100.0 False True 5907411.258062167 6640474.148551012 4190748.367445067 1.0 1.1240920698535073 0.7094052173404591 22.494094621324354 -6.826499234858451 1.3435393335064132 1.0664830209941845 0.6990279495608508 0.8986778067301426 0.05531758786632196 0.18517160227301038 0.6549397906793673 0.03233900371079654 0.07443860440389594 1.4910793824393151e-07 6.826499234858451 -0.36745507143333367 GLTK(ub)EQIDNLAMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLTKEQIDNLAMR 13 1 Q9NVW2;Q9NVW2-2 Q9NVW2 RLIM E3 ubiquitin-protein ligase RLIM 1 13344700.0 3291600.0 4230500.0 5822600.0 True False 3187109.9597307453 5919760.71176606 4297486.385744221 1.0 1.85740711383117 1.348396020232475 21.603817364286062 -10.43286090602412 5.270000451562612 0.9993813811878781 1.602901567031833 0.6516387524230087 0.20780290878884583 0.0015118470213309288 0.00016269961278157454 0.2013992828388079 0.0670681004193829 3.6909579206073646e-11 10.43286090602412 0.6035201858439548 GLTK(ub)EQIDNLAMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLTKEQIDNLAMR 13 1 Q9NVW2;Q9NVW2-2 Q9NVW2 RLIM E3 ubiquitin-protein ligase RLIM 1 8700900.0 3291600.0 3267500.0 2141800.0 True False 2737111.24260455 3249897.328952032 2589640.4774356955 1.0 1.1873457236102436 0.9461217495023966 21.38422263972034 -6.699450339003185 1.8332925446820847 1.1164013215212947 0.9468581178168028 0.41474016961350413 0.0790894807517107 0.39667651862898307 2.591687809802363 0.03442532963175112 0.08857777133811691 1.997789199921928e-07 6.699450339003185 -0.16954320370449183 GLTPSQIGVILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLTPSQIGVILR 12 0 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 0 394270000.0 127950000.0 120800000.0 145520000.0 False True 167743689.06956246 102777110.87471186 130462986.32640663 1.0 0.6127032942031619 0.777751980119528 27.32168324880713 -10.184682899609374 5.360224924176541 1.0000129924944337 0.6952276371612758 0.8197022280672015 0.06738084386890589 1.0462472632073255e-05 1.5912716766625573e-06 0.06524400129002293 0.02174707384643785 6.536076104743952e-11 10.184682899609374 -0.30478535533315787 GLTPSQIGVILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLTPSQIGVILR 12 0 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 0 376056000.0 162950000.0 87516000.0 125590000.0 False True 157777241.44432032 122461595.18991083 92694211.38076073 1.0 0.7761676783601746 0.5875005199243046 27.23331387811728 -6.973101016064007 0.1683736011956385 1.1703874331679944 0.1882360559228384 0.9999975675682767 0.00026289892123769807 0.07530869454538908 0.005242872881111923 0.008071051004950742 0.02197887716939597 1.0638955293819266e-07 6.973101016064007 -0.982151377245156 GLTPSQIGVILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLTPSQIGVILR 12 0 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 0 256701000.0 73678000.0 112500000.0 70523000.0 False True 111774912.58330424 92423496.03348799 56584098.138670996 1.0 0.8268715572880102 0.5062325420876503 26.7360211766799 -6.961519811668805 0.4134572049052641 1.0152117393530127 0.30592585452320675 0.999822477999955 0.0027254471002926767 0.07916261415101047 0.01915782034240497 0.004133638592494106 0.026741777405602192 1.092647781587296e-07 6.961519811668805 -0.7092858848298059 GLTPSQIGVILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLTPSQIGVILR 12 0 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 0 380230000.0 127950000.0 106200000.0 146080000.0 False True 175256572.71873692 101507732.84356351 111578912.61203733 1.0 0.5791950125971577 0.6366603596151934 27.38489331033002 -10.29067473884417 5.611395033783981 1.0000410262599981 0.6079276861063366 0.984143783789306 0.02346012968104813 1.2042310849993555e-05 1.5222357857884845e-06 0.02271754322267576 0.00757172429621055 5.1206519883639906e-11 10.29067473884417 -0.3921133401536615 GLTPSQIGVILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLTPSQIGVILR 12 0 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 0 300831000.0 162950000.0 63486000.0 74395000.0 False True 135500144.90898386 63143988.317015655 89950650.53638461 1.0 0.4660067954866749 0.6638417294446801 27.013719153551556 -10.274952945482646 5.165659712418274 1.0000782018600836 0.5649242624655931 0.8657457966681138 0.08076577358270161 7.275300548247969e-05 1.0211539595271074e-05 0.07821511168500063 0.026067041335734915 5.309419671000693e-11 10.274952945482646 -0.43515393939449043 GLTPSQIGVILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLTPSQIGVILR 12 0 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 0 234092000.0 73678000.0 106040000.0 54374000.0 False True 95377623.41050644 100138780.78334859 44478489.92435401 1.0 1.049919018765545 0.4663409333750963 26.507147498772348 -6.886099423537744 1.0452240666424335 1.034350903980061 0.419829618873929 0.9782803357090908 0.03892533031617321 0.12236318343157154 0.24081396197095353 0.028512021408326177 0.07014993847565801 1.299871962776924e-07 6.886099423537744 -0.6145212851061319 down GLTPTGMLPSGVLSGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLTPTGMLPSGVLSGGK 17 0 Q08209-2;Q08209-3;Q08209;E7ETC2;Q08209-5;Q08209-4 Q08209-2 PPP3CA Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 0 3191610.0 526090.0 1763200.0 902320.0 False True 689709.0846628072 1500137.4328997685 808956.5820646171 1.0 2.1750292496628094 1.1728953555253068 19.395628444130782 -6.607397091004603 2.163619079926983 1.786433268692035 1.176422914983604 0.042239545658834476 0.5069359307787771 0.6199232690740781 5.495487055080078 0.19375443639212384 0.5629538434128575 2.4694651919522373e-07 6.607397091004603 -0.6100103537084309 GLTPTGMLPSGVLSGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLTPTGMLPSGVLSGGK 17 0 Q08209-2;Q08209-3;Q08209;E7ETC2;Q08209-5;Q08209-4 Q08209-2 PPP3CA Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 0 4203590.0 526090.0 1649400.0 2028100.0 False True 720599.6900476777 1576524.0541635915 1549104.5500306203 1.0 2.1877945216147436 2.149743569731657 19.458838505653674 -10.522199174549977 6.325699422314 0.9988900489144912 2.1687690456731863 0.9992056902908415 0.015534236056792876 0.00024333391391270857 1.837980362399979e-05 0.015051287934722067 0.005013653128667816 3.004697982971582e-11 10.522199174549977 1.1698789967586951 GLTSVINQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLTSVINQK 9 0 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 57676400.0 3425400.0 30028000.0 24223000.0 False True 4490732.571620782 25547939.448227268 21716636.323423237 1.0 5.689036040506545 4.835878328774615 22.09851937982193 -10.03795273841891 5.487043289452927 0.9999775687834633 5.26245718464383 0.970829569317307 0.34830017732205715 9.55767030755425e-05 1.6760102560502976e-05 0.33724193754236675 0.11241339885246034 9.163202021538709e-11 10.03795273841891 4.262479615860367 GLTSVINQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLTSVINQK 9 0 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 38254200.0 15293000.0 3974200.0 18987000.0 False True 14807532.085964967 5561118.785179215 14013735.102209602 1.0 0.3755601374283169 0.9463923509233689 23.819827876477312 -10.622444197706287 9.484328704838696 1.0000889952438667 0.6609762441758469 0.3198702366432219 0.23304127530105787 0.0004386525560713455 1.746212089082758e-05 0.22569962229189658 0.07521374818499459 2.385370270879411e-11 10.622444197706287 -0.33911275106801986 GLTSVINQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLTSVINQK 9 0 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 137927600.0 3106100.0 131870000.0 2951500.0 False True 4712180.786326998 108336768.19498727 2368134.7313115927 1.0 22.99079197244308 0.5025560008612238 22.16796345962457 -6.410595206549362 3.102322674516817 9.999999999999998 0.3497283506732485 0.24246631857564427 9.12644148648387 0.7176153111790667 12.325813891146197 3.579446505396323 14.073554255673528 3.885123184887477e-07 6.410595206549362 -9.65027164932675 GLTSVINQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLTSVINQK 9 0 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 41412400.0 3425400.0 18239000.0 19748000.0 False True 4691862.947954366 17433140.67169257 15083929.122826647 1.0 3.715611658966584 3.2149125603515722 22.16172944134482 -10.57860724100218 8.565808008464732 0.9993942497579817 3.465262109659078 0.9699906740923286 0.2044095510463757 0.002364883707251346 0.00011633927872305288 0.19793900726201707 0.06597289891736231 2.638716659561156e-11 10.57860724100218 2.4658678599010964 GLTSVINQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLTSVINQK 9 0 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 18525900.0 15293000.0 1622800.0 1610100.0 False True 12716807.094771957 1614057.6542994196 1946764.465738731 1.0 0.12692318459112112 0.15308594769351114 23.60023315191159 -10.158773712536243 4.665741107491506 1.0001020636531959 0.14000456613357282 0.9993063586569425 0.01068090334049178 26588786.843576435 36924858.7155988 35484.44447667761 0.00390881475100888 6.937872070018274e-11 10.158773712536243 -0.860097497519623 GLTSVINQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLTSVINQK 9 0 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 10257200.0 3106100.0 3880900.0 3270200.0 False True 4020907.680384557 3664924.5034147245 2675057.155085564 1.0 0.9114669608788962 0.6652868873700983 21.93908978171702 -6.953143941119252 0.523190956230434 1.004082450951402 0.5616251562158736 0.9994254726690964 0.0033942412386688088 0.08224731783150538 0.03092366272838839 0.0038260001051905915 0.020341313993603356 1.113925276712052e-07 6.953143941119252 -0.4424572947355283 GLTSVINQK(ub)LK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLTSVINQKLK 11 1 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 95195900.0 38071000.0 41717000.0 15407900.0 True False 49911449.680088416 35492986.211592406 13813638.311013196 1.0 0.7111191207445917 0.2767629151137236 25.572867471795703 -7.1037843584571565 0.3831001755155928 1.0318008824400633 1.1269337039341979e-13 0.9998526820371869 0.0036077905847002978 0.07666774258239044 0.018520603258304444 0.006645077367726084 0.03659458181345851 7.874366809409238e-08 7.1037843584571565 -1.0318008824399505 down GLTSVINQK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLTSVINQKLK 11 1 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 162491600.0 63891000.0 70474000.0 28126600.0 True False 61862815.177165285 98614635.71705496 20759399.68008681 1.0 1.5940858080033748 0.33557153227888487 25.882569151530124 -6.778309388294679 1.5422388370205533 1.3371139841407889 0.32608037399873063 0.7614711092609014 0.2510608677608557 0.2531892455262711 1.1893301752373862 0.12822738367794156 0.3030207523036856 1.666059900482062e-07 6.778309388294679 -1.0110336101420583 GLTSVINQK(ub)LK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLTSVINQKLK 11 1 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 96019000.0 43054000.0 20595000.0 32370000.0 True False 65316065.66901343 16919661.340530537 25972055.311724998 1.0 0.25904287355993316 0.3976365545857792 25.960934556599984 -9.88693007698695 6.6097068182738195 1.0000000295177909 0.32833971411032276 0.9690545355058239 0.05658063334798805 2.4605284688234882e-08 4.199236300547133e-09 0.05478396511763809 0.018261320889538482 1.2973881384437063e-10 9.88693007698695 -0.6716603154074681 GLTSVINQK(ub)LK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLTSVINQKLK 11 1 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 93450400.0 38071000.0 35558400.0 19821000.0 True False 52146877.53009013 33987312.31209571 15139688.02630881 1.0 0.6517612160475789 0.2903277960904334 25.636077533318595 -7.379705059167177 0.30454740367637917 1.0783031995135943 1.918100108576703e-12 0.9997929952962289 0.004168663893598743 0.11396824547563553 0.025449043315689097 0.016613693840717397 0.055730855000684726 4.17152586613876e-08 7.379705059167177 -1.0783031995116763 down GLTSVINQK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLTSVINQKLK 11 1 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 138666400.0 63891000.0 62711000.0 12064400.0 True False 53128197.35121141 62373163.39584114 14587010.260516964 1.0 1.1740124172389022 0.2745624920056573 25.6629744269644 -6.856541104585882 1.2030105224631518 1.0936816174106072 0.23378264881285904 0.9493002588657373 0.08770723689655774 0.15041295028827387 0.4156114325564307 0.05693570279265917 0.1324361152244222 1.3914220949542156e-07 6.856541104585882 -0.8598989685977482 down GLTSVINQK(ub)LK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLTSVINQKLK 11 1 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 84579000.0 43054000.0 34217000.0 7308000.0 True False 55734251.721218504 32312793.870839637 5978018.986412244 1.0 0.5797654561232385 0.10725933876916771 25.732060878692433 -7.695353196486858 0.47177044352034175 1.024433467563452 2.1612419948420653e-20 0.9965786284990619 0.021330341051448702 0.11669062180101915 0.08335644714659778 0.02848451716371149 0.07543963119920385 2.0167255643231136e-08 7.695353196486858 -1.024433467563452 down GLTSVINQK(ub)LKDDEVAQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLTSVINQKLKDDEVAQLK 19 2 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 164388200.0 110230000.0 35455000.0 18703200.0 True False 144512597.46883857 30165252.20250759 16767972.277762836 1.0 0.2087378728972895 0.1160312150736792 27.10662002008542 -13.999999999999998 0.3025643463409176 8.325066068794024 0.09382100595842524 0.9996555446864517 0.00736191249938822 16.757396371386307 0.1747671098463315 76.95735500515083 0.033138410987446985 1.0000000000000041e-14 13.999999999999998 -8.2312450628356 GLTSVINQK(ub)LKDDEVAQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLTSVINQKLKDDEVAQLK 19 2 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 479740000.0 135658000.0 214577000.0 129505000.0 True False 131351611.04543479 300258715.10427284 95583755.43327808 1.0 2.2859157395520087 0.7276938186941267 26.968858654530518 -6.687483597061062 1.8751382018867826 1.8080634440321748 0.7331989346770162 0.35879838868770686 0.5441299231003773 0.4220834647036519 2.8753562595961655 0.2323014331819479 0.6069038647225028 2.0536025878426417e-07 6.687483597061062 -1.0748645093551585 GLTSVINQK(ub)LKDDEVAQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLTSVINQKLKDDEVAQLK 19 2 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 436751000.0 101080000.0 135460000.0 200211000.0 True False 153345749.9378426 111286104.64618923 160639208.0944014 1.0 0.7257201760811637 1.0475621799724812 27.19221294116802 -6.681015261536835 1.8984974649395956 0.8266132121867263 1.0463395317471178 0.32863360815473075 0.11622148528013304 0.4362992574058027 3.0413031450299175 0.049108261599797 0.12934123160281955 2.0844176333168627e-07 6.681015261536835 0.21972631956039146 GLTSVINQK(ub)LKDDEVAQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLTSVINQKLKDDEVAQLK 19 2 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 188192000.0 110230000.0 44833000.0 33129000.0 True False 150985009.85374284 42852129.817094885 25304612.513172172 1.0 0.2838171144182139 0.1675968530762386 27.16983008160831 -13.999999999999998 0.2559124324233361 6.132970761802743 0.12342612504274766 0.9995541103881052 0.007772328798700956 14.240251313331697 0.16007575707778546 37.70822879569177 0.05192792312860634 1.0000000000000041e-14 13.999999999999998 -6.009544636759995 GLTSVINQK(ub)LKDDEVAQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLTSVINQKLKDDEVAQLK 19 2 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 358676000.0 135658000.0 176517000.0 46501000.0 True False 112805637.66838247 175566067.88511878 56224144.10366861 1.0 1.5563589862523957 0.49841608332512705 26.749263929964794 -6.763803515394339 1.5980153876523653 1.321632411234905 0.4937892728641173 0.7063445105548494 0.2341529382943136 0.2765777316300224 1.3927841008370245 0.11556276523018534 0.27669801442190967 1.7226477633605897e-07 6.763803515394339 -0.8278431383707876 down GLTSVINQK(ub)LKDDEVAQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLTSVINQKLKDDEVAQLK 19 2 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 306192000.0 101080000.0 121580000.0 83532000.0 True False 130850052.58467887 114813966.1225905 68330033.11069883 1.0 0.8774468474003041 0.5222010366902943 26.96333926326047 -6.952220381005895 0.5339134382729979 1.005449985684479 0.3779628181165097 0.9993641959373052 0.005109208583920903 0.08260625065336456 0.03236610792726023 0.005667740204759572 0.029392470703760054 1.1162966437444e-07 6.952220381005895 -0.6274871675679692 GLTSVINQK(ub)LKDDEVAQLKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLTSVINQKLKDDEVAQLKK 20 3 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 86752000.0 48864000.0 25022000.0 12866000.0 True False 64061177.19964912 21288815.134992063 11534749.739386652 1.0 0.33232007380452366 0.180058348029387 25.93294697378981 -13.999999999999998 0.2076940424571092 4.8253034299867466 0.08834558189647852 0.999488847002183 0.008051022417569316 12.693695190574882 0.14446436976879787 19.793173637287293 0.09167181311372721 1.0000000000000041e-14 13.999999999999998 -4.736957848090268 GLTSVINQK(ub)LKDDEVAQLKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLTSVINQKLKDDEVAQLKK 20 3 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 111737000.0 60283000.0 31148000.0 20306000.0 True False 58369349.16224585 43585558.83467419 14987249.433057759 1.0 0.7467199730722022 0.2567657451755815 25.79870764598942 -7.0293327939987655 0.4436868317171229 1.0173669870190176 4.9873350681863784e-15 0.9997698174508548 0.004680631242832774 0.07355439563218126 0.021469795294769996 0.0064938888297382145 0.03748652979378168 9.346891599695044e-08 7.0293327939987655 -1.0173669870190127 down GLTSVINQK(ub)LKDDEVAQLKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLTSVINQKLKDDEVAQLKK 20 3 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 461500000.0 115680000.0 118620000.0 227200000.0 True False 175495017.34081575 97451334.21770987 182293820.41470242 1.0 0.5552940231257787 1.0387407185509046 27.386854829174364 -6.664861372675538 1.9552950855108573 0.7148980848842058 1.036758318243383 0.25649226209644704 0.18912889944459974 0.47310440101631446 3.4818794761012115 0.07800344069101044 0.20983460211968386 2.1634089762891732e-07 6.664861372675538 0.32186023335917724 GLTSVINQK(ub)LKDDEVAQLKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLTSVINQKLKDDEVAQLKK 20 3 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 83027000.0 48864000.0 21830000.0 12333000.0 True False 66930341.29994814 20865478.417843614 9420199.406107996 1.0 0.3117491710423981 0.1407463225667922 25.996157035312702 -13.999999999999961 0.195557186542357 4.763045266114221 0.024698044559711082 0.9994873007050807 0.008408902064016135 12.446529518870385 0.14023382634816314 17.882973266264763 0.11260615238191184 1.00000000000009e-14 13.999999999999961 -4.73834722155451 GLTSVINQK(ub)LKDDEVAQLKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLTSVINQKLKDDEVAQLKK 20 3 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 120815500.0 60283000.0 52924000.0 7608500.0 True False 50127985.48971017 52638887.90740846 9199402.172270741 1.0 1.0500898329180555 0.18351828988139 25.579112921423697 -6.893190060834402 1.0033009425879833 1.0430638042933327 0.10414904823938591 0.9828634586711417 0.051999531141321276 0.11659374746751418 0.20702469271697668 0.0393152361423423 0.09921078876895321 1.2788215294221547e-07 6.893190060834402 -0.9389147560539468 down GLTSVINQK(ub)LKDDEVAQLKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLTSVINQKLKDDEVAQLKK 20 3 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 398329000.0 115680000.0 209110000.0 73539000.0 True False 149750040.3937047 197472844.6775366 60155656.57386014 1.0 1.318683081208959 0.40170711417309907 27.157981151266814 -6.812822676380082 1.402508853119278 1.1731088748364835 0.3845863610389921 0.8671067598988053 0.13856759892244427 0.20297063818732353 0.7863132907035169 0.07767295486793553 0.17946554249813398 1.5387828012635744e-07 6.812822676380082 -0.7885225137974914 down GLTVPIASIDIPSGWDVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLTVPIASIDIPSGWDVEK 19 0 Q8NCW5-2;Q8NCW5 Q8NCW5-2 APOA1BP NAD(P)H-hydrate epimerase 0 5757000.0 3550700.0 0.0 2206300.0 False True 2952564.372680758 0.0 2667627.1292213923 1.0 0.0 0.903494993675393 21.493537083353008 -9.149042689185404 12.223708882117124 1.0000051455608046 0.45174749614364784 0.32929240104073465 0.3688502866226036 0.0 0.0 0.35713775432788736 0.11904591810929577 7.095080231025698e-10 9.149042689185404 -0.5482576494171567 GLTVVVAFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLTVVVAFR 9 0 P14324;P14324-2;A0A087WVN4;A0A087X1D8 P14324 FDPS Farnesyl pyrophosphate synthase 0 3704780.0 1722700.0 697880.0 1284200.0 False True 1668013.8314583038 976547.1233961226 947829.494825805 1.0 0.5854550513782918 0.5682383904437656 20.669699821232392 GLTVVVAFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLTVVVAFR 9 0 P14324;P14324-2;A0A087WVN4;A0A087X1D8 P14324 FDPS Farnesyl pyrophosphate synthase 0 91152000.0 15619000.0 29863000.0 45670000.0 False True 23695164.901851665 24533714.329316042 36643304.48212789 1.0 1.0353890521943085 1.5464464853445434 24.4980893653701 -6.9208931996244205 0.8180561010430519 0.9890837173121553 1.63058188773977 0.9944260653528831 0.018640388777103584 0.09764834308172916 0.10290489715664662 0.016137216021686263 0.04876061149666803 1.1997943166357397e-07 6.9208931996244205 0.6414981704276147 GLTVVVAFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLTVVVAFR 9 0 P14324;P14324-2;A0A087WVN4;A0A087X1D8 P14324 FDPS Farnesyl pyrophosphate synthase 0 4387540.0 1722700.0 842840.0 1822000.0 False True 1432501.3785499015 838299.4536293579 2202971.776023827 1.0 0.5851997535094557 1.5378496726152266 20.450105096666668 -6.788362232118379 1.502889477480217 0.7676746013675121 1.5475272021951727 0.7959727503377989 0.17615949576777054 0.23779934283748053 1.0611119519767185 0.09227039140907249 0.21628634512523012 1.6279376518194023e-07 6.788362232118379 0.7798526008276606 GLTVVVAFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLTVVVAFR 9 0 P14324;P14324-2;A0A087WVN4;A0A087X1D8 P14324 FDPS Farnesyl pyrophosphate synthase 0 57922000.0 15619000.0 19543000.0 22760000.0 False True 20219103.396518618 18455414.870322324 18617913.537321124 1.0 0.912771180224541 0.9208080681029016 24.269215687462548 -10.339824400027334 5.630213854035169 1.000015967895234 0.9167896241637207 0.9930520692560534 0.003281045736992746 6.577635604104153e-07 7.713102964154153e-08 0.003177468385572316 0.0010589529581261446 4.572730432245759e-11 10.339824400027334 -0.08322634373151339 GLVAIPVSIFYSVPHQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLVAIPVSIFYSVPHQK 17 0 A0A494C066;B7Z4W5;Q16773-2;Q16773 A0A494C066 CCBL1 Kynurenine--oxoglutarate transaminase 1 0 5317130.0 866730.0 2935100.0 1515300.0 False True 1136291.4234252595 2497194.520930194 1358511.291783974 1.0 2.1976708346548994 1.1955659118581135 20.115901458050168 -6.60244068393075 2.18207314744097 1.8042116288402037 1.19893600040724 0.027435167869783283 0.5173567680360358 0.6338250190927466 5.707443512048806 0.19657625353786784 0.5750448317762921 2.4978095174232285e-07 6.60244068393075 -0.6052756284329637 GLVAIPVSIFYSVPHQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLVAIPVSIFYSVPHQK 17 0 A0A494C066;B7Z4W5;Q16773-2;Q16773 A0A494C066 CCBL1 Kynurenine--oxoglutarate transaminase 1 0 8718100.0 3399500.0 2655600.0 2663000.0 False True 3291584.7332922183 3715994.928771056 1965480.4117124437 1.0 1.1289379523444154 0.5971228362535832 21.650350905992024 -6.842649079966576 1.270041195619724 1.0685856062637304 0.5786940361700957 0.9289134927210632 0.06039230120956374 0.1657267002668936 0.5181194934323767 0.03726933890544697 0.08593185189530404 1.4366498109162974e-07 6.842649079966576 -0.4898915700936347 GLVAIPVSIFYSVPHQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLVAIPVSIFYSVPHQK 17 0 A0A494C066;B7Z4W5;Q16773-2;Q16773 A0A494C066 CCBL1 Kynurenine--oxoglutarate transaminase 1 0 11228530.0 866730.0 4960800.0 5401000.0 False True 1187183.5034975451 4741615.452828144 4125395.037086619 1.0 3.9940038240583156 3.474943026863875 20.17911151957306 -10.664859691442617 9.101462600610681 0.997564395752275 3.734473425461095 0.9736870404563048 0.21190568310144034 0.010454847517743341 0.000384975001177137 0.2048251914082598 0.0683922651348821 2.1634173512549715e-11 10.664859691442617 2.73690902970882 GLVAIPVSIFYSVPHQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLVAIPVSIFYSVPHQK 17 0 A0A494C066;B7Z4W5;Q16773-2;Q16773 A0A494C066 CCBL1 Kynurenine--oxoglutarate transaminase 1 0 6582100.0 3399500.0 1459400.0 1723200.0 False True 2826834.87338503 1451537.9225317799 2083513.1528234158 1.0 0.5134852184675425 0.7370480576845602 21.4307561814263 -10.346975999364027 5.862949610879097 1.000055600096961 0.625266638076051 0.789302547830837 0.09126914692159763 6.634097272124943e-05 7.389122694402128e-06 0.08838403410106817 0.02945699050415838 4.498047119921128e-11 10.346975999364027 -0.37478896202090994 GLVAMANAGSHDNGSQFFFTLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLVAMANAGSHDNGSQFFFTLGR 23 0 D6REK3;Q6UX04-2;Q6UX04 D6REK3 CWC27 Peptidyl-prolyl cis-trans isomerase CWC27 homolog 0 95774000.0 33643000.0 38019000.0 24112000.0 False True 51038890.63275472 31234212.406197175 19346252.631334964 1.0 0.6119688735192121 0.37904923856082623 25.605093635633736 -8.966447358579734 0.15453620654756384 1.4845355763030172 5.715251244557931e-08 0.999832249559267 0.0033172861461949555 0.4440926722060163 0.04912973653117045 0.26584876620219 0.16565940225566977 1.0803205600591364e-09 8.966447358579734 -1.4845355191505047 GLVAMANAGSHDNGSQFFFTLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLVAMANAGSHDNGSQFFFTLGR 23 0 D6REK3;Q6UX04-2;Q6UX04 D6REK3 CWC27 Peptidyl-prolyl cis-trans isomerase CWC27 homolog 0 91895000.0 33643000.0 28645000.0 29607000.0 False True 43551526.702674694 27050880.569021277 24218829.79347391 1.0 0.6211235889317277 0.5560960000051278 25.376219957726185 -13.999999999999998 0.24794334744272922 3.6078418953109397 0.5294331063779035 0.9995388657082596 0.004203320229424958 13.917408447048002 0.15756917108443286 18.054504141459716 0.03035693944460613 1.0000000000000041e-14 13.999999999999998 -3.0784087889330363 GLVASLISVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLVASLISVK 10 0 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 0 14672800.0 4387800.0 4583700.0 5701300.0 False True 5752448.29151565 3899829.827122661 5111384.166731319 1.0 0.6779426132129798 0.8885580378480162 22.455744679514655 -10.159340542891472 4.899060359207973 1.00001650125714 0.7832503255298224 0.5854289896703577 0.08598338705490861 1.5498122699060652e-05 2.6595262359959093e-06 0.08325939202042955 0.027751018842514394 6.928822838664117e-11 10.159340542891472 -0.2167661757273176 GLVASLISVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLVASLISVK 10 0 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 0 14901500.0 6617800.0 1661000.0 6622700.0 False True 6407721.561400569 2324245.9620005693 4888016.193258722 1.0 0.3627258050664341 0.7628321777749536 22.61138002813288 -9.962320936395201 5.380224780258547 1.0000009668880088 0.5627789914227032 0.61422305388071 0.16334274266692367 50648108.879699215 93782808.81596278 460.8919853756999 0.05591657631624085 1.09063407814478e-10 9.962320936395201 -0.4372219754653056 GLVASLISVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLVASLISVK 10 0 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 0 25243300.0 4387800.0 6536500.0 14319000.0 False True 6010088.23583646 6247695.816685048 10937147.1090619 1.0 1.0395347907592771 1.8197980927878528 22.518954741037547 -6.917416634264024 0.8436490312008463 0.9811302781404728 1.9384447236896536 0.9934332056202936 0.030589645005499197 0.09971540532343515 0.11366071634968217 0.026001902357001932 0.07606601619333526 1.209437320260312e-07 6.917416634264024 0.9573144455491808 GLVASLISVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLVASLISVK 10 0 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 0 12373900.0 6617800.0 2968100.0 2788000.0 False True 5502993.918248991 2952110.2561782775 3370957.9097444755 1.0 0.5364553005207783 0.6125679875032622 22.391785303567158 -10.727205647502156 6.885427137679011 1.0056309546922546 0.5745116440120795 0.9765630910212143 0.031072874343210204 0.0026999587907506834 0.0001069697459691483 0.030243216618749413 0.010028727070837398 1.8741068692056692e-11 10.727205647502156 -0.43111931068017506 GLVASLISVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLVASLISVK 10 0 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 0 10303600.0 1969800.0 5552300.0 2781500.0 False True 2549944.9305629297 5243309.62413604 2275295.5406001164 1.0 2.0562442589607293 0.8922920308313556 21.28203465983511 -6.667740303451577 1.9449757999706074 1.6754703910950242 0.89699119315723 0.2693152991489767 0.44889828055746156 0.4662828640119722 3.3983355853351758 0.18593296106429869 0.49830860564251706 2.1491152037029116e-07 6.667740303451577 -0.7784791979377942 GLVAVITGGASGLGLATAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLVAVITGGASGLGLATAER 20 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 39417200.0 15077000.0 9590200.0 14750000.0 False True 14598388.887732552 13419616.872232305 10886532.509484993 1.0 0.9192532803061025 0.7457352036040951 23.7993058229104 -6.958616195269696 0.45451617414438633 1.0053443999960607 0.6527131874039014 0.9997153802712563 0.0017896536633946107 0.08019919815798568 0.022986107013131207 0.002335416022558508 0.014343765272581379 1.099977507494919e-07 6.958616195269696 -0.35263121259215935 GLVAVITGGASGLGLATAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLVAVITGGASGLGLATAER 20 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 167276000.0 23715000.0 82256000.0 61305000.0 False True 35977388.798733056 67576774.13093857 49188039.87906394 1.0 1.8783123619387934 1.3671931599659646 25.10058714530277 -10.384753874271448 5.187123201758956 0.9995991718565387 1.6227527609524102 0.6643578956272767 0.20866354042876978 0.0009678374402445202 0.00011479530003355258 0.20216294926920078 0.06734586808675969 4.1233113143328573e-11 10.384753874271448 0.6231535890958715 GLVAVITGGASGLGLATAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLVAVITGGASGLGLATAER 20 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 3793400.0 0.0 0.0 3793400.0 False True 0.0 0.0 2897477.047525349 0.0 GLVAVITGGASGLGLATAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLVAVITGGASGLGLATAER 20 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 31028500.0 15077000.0 5693500.0 10258000.0 False True 12537193.5243495 5662827.985428728 12402900.372366864 1.0 0.45168226640439835 0.9892884199544488 23.579711098344678 -10.946540715734514 10.298583585015601 1.0786773417923559 0.720485343179429 0.2649376251435045 0.21947679312966115 0.11368921823281226 0.0005901527404718747 0.06093628101106001 0.07083583038918236 1.1309913522915355e-11 10.946540715734514 -0.35819199861292683 GLVAVITGGASGLGLATAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLVAVITGGASGLGLATAER 20 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 126077000.0 23715000.0 64956000.0 37406000.0 False True 30699534.992537197 61341141.49908705 30598491.817971587 1.0 1.9981130500510373 0.9967086415286038 24.87171346739522 -6.6469339305648525 2.019606809025529 1.649238463255138 1.0009182230245461 0.18171292170106113 0.42632770830123484 0.5160480086311192 4.03099441283788 0.17141358855604075 0.47212087129248304 2.2545821767699706e-07 6.6469339305648525 -0.6483202402305919 GLVGEIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLVGEIIK 8 0 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 42623800.0 6967800.0 15762000.0 19894000.0 False True 9134853.276271177 13410371.039794771 17835559.716723006 1.0 1.468044492255802 1.952473584119069 23.12295012584022 -6.970693324041104 0.24105100342993158 0.8283066610371506 2.606241070409235 0.9999872966840845 0.0013859689912772515 0.07607835149038948 0.00822095554650832 0.01149404289847869 0.047138964399789485 1.0698100562455187e-07 6.970693324041104 1.7779344093720846 GLVGEIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLVGEIIK 8 0 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 35361200.0 19087000.0 7797600.0 8476600.0 False True 18481093.632695556 10911222.34394681 6256324.167450869 1.0 0.5903991701358724 0.3385256463601583 24.139546796061957 -8.68372711960007 0.17913716845104288 1.3841198127013314 1.1927589478055301e-08 0.9997718558704981 0.004117357497922917 0.25025489020771285 0.04991682777371388 0.19286668493157738 0.14119564345485588 2.0714424901412363e-09 8.68372711960007 -1.3841198007737419 down GLVGEIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLVGEIIK 8 0 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 56920800.0 6967800.0 22267000.0 27686000.0 False True 9543983.957714848 21283170.31287786 21147137.011068344 1.0 2.23000902004594 2.21575571635094 23.18616018736311 -10.084529622240721 5.40370737541079 0.9999861818496154 2.222882368199214 0.999898122294521 0.00581888686966327 9.686984647913268e-07 1.6410046615134352e-07 0.005634176534881229 0.0018780376612460793 8.23133690926156e-11 10.084529622240721 1.2228961863495986 GLVGEIIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLVGEIIK 8 0 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 24026000.0 19087000.0 3083800.0 1855200.0 False True 15871686.19747023 3067186.957313623 2243113.7425243724 1.0 0.19324896669154776 0.14132800476372195 23.919952071496233 -13.586709515117786 0.3938039728650519 9.999999999999481 0.13776239893755993 0.9998201797187509 0.005271565721243342 18.479352497451085 0.205552935216344 139.9554709249697 0.013522102631178872 2.5899446622746483e-14 13.586709515117786 -9.86223760106192 GLVGEIIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLVGEIIKR 9 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 12487800.0 3855400.0 5728500.0 2903900.0 True False 3205935.923179485 5697639.433481774 3511092.0638834196 1.0 1.7772156306327995 1.095184728583501 21.612314160058364 -10.205469697524636 4.612052775049272 0.9999176517413421 1.4362001794882 0.35291159558941865 0.27843794990498605 195840817.28555614 33.698751508888535 196458.54482734235 0.09531671625195146 6.23060619361575e-11 10.205469697524636 0.43628252774685794 GLVGEIIKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLVGEIIKR 9 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 3968150.0 1453500.0 1554000.0 960650.0 False True 1905552.5757140238 1322149.2574445568 861251.1532054867 1.0 0.6938403454699423 0.45196924198366445 20.861777983129198 -7.378957689705175 0.17246131269498882 1.237274611448397 5.575757356267181e-11 0.9999837656951571 0.0009035060900222116 0.11846298649243753 0.012355669368056123 0.026868932240751913 0.0547280887512319 4.178710749399852e-08 7.378957689705175 -1.2372746113926394 down GLVGEIIKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLVGEIIKR 9 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 41348300.0 6918300.0 15102000.0 19328000.0 False True 10495566.895478612 12406930.107535427 15507812.328236654 1.0 1.1821114791693828 1.4775583332156426 23.323276757016725 -6.963921698957023 0.37610290393645807 0.9787951073266978 1.6912581071146804 0.9998891575370544 0.002071768029277037 0.07832882989074239 0.01616219063932327 0.0038618213513832685 0.02501272353879372 1.0866215181820097e-07 6.963921698957023 0.7124629997879826 GLVGEIIKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLVGEIIKR 9 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 6219000.0 1453500.0 2406700.0 2358800.0 False True 1990898.229360566 2300364.036107381 1801700.0210109106 1.0 1.1554402943269524 0.9049684179937104 20.92498804465209 -6.738838495328006 1.6907970503632443 1.0926086101781267 0.9048536584608604 0.5998060023439121 0.06531134731832335 0.3199096119668584 1.795258217429494 0.03056295701620689 0.0750989779886185 1.8245740955939668e-07 6.738838495328006 -0.1877549517172663 GLVGEIIKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLVGEIIKR 9 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 36959300.0 6918300.0 14871000.0 15170000.0 False True 8955875.730080977 14043415.777340382 12409215.657344509 1.0 1.5680672890727354 1.3855948911466536 23.094403079109174 -10.211707940128653 4.579089096147674 0.9998835777849062 1.4768310901126958 0.9010377660271236 0.07449404452583062 8777121.124192525 19573650.183590095 6678.851402346845 0.02550129380756827 6.141748944534601e-11 10.211707940128653 0.47694751232778954 GLVGIEFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLVGIEFK 8 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 27113700.0 7249500.0 7111200.0 12753000.0 False True 9504164.70425786 6050236.679240495 11433441.895414116 1.0 0.6365879451278861 1.2029928195890733 23.18012840714184 -6.733410194864115 1.7106216526823999 0.7821380828309705 1.2028826886357726 0.5750826774627853 0.15273321959682656 0.32987985842932843 1.8925776147188267 0.07070865173765943 0.1747970859760312 1.8475227935053153e-07 6.733410194864115 0.4207446058048021 GLVGIEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLVGIEFK 8 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 18443700.0 5865700.0 3276500.0 9301500.0 False True 5679496.564221844 4584823.536721779 6865158.110981327 1.0 0.8072587921971834 1.2087617332544212 22.43733162291157 -6.776148175028571 1.5506683217075377 0.8903197314964751 1.2115780467979231 0.753596984570787 0.08138630376176384 0.25660489768537037 1.2184080320366126 0.04134813542669616 0.0978915423392015 1.6743715070932843e-07 6.776148175028571 0.321258315301448 GLVGIEFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLVGIEFK 8 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 20406400.0 4971800.0 9182500.0 6252100.0 False True 7542584.087267187 7543811.131800035 5016369.694607218 1.0 1.0001626822477085 0.6650730885553492 22.846627444435914 -6.906785180355472 0.9173569203110024 1.0114590874063536 0.6246200956139312 0.9896505951040754 0.016065969876142058 0.10658224356756928 0.15058596288391507 0.012947827516799612 0.03499339821749069 1.239409497079866e-07 6.906785180355472 -0.3868389917924224 GLVGIEFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLVGIEFK 8 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 28345800.0 7249500.0 8480300.0 12616000.0 False True 9929836.06037111 8105612.30539803 9636360.63467596 1.0 0.8162886331776052 0.9704450885280594 23.24333846866473 -10.092875181592607 5.751840218885852 1.0000006460337059 0.8933668608721943 0.3894878979163793 0.06293410936083164 5.214025046190275e-07 8.21695715058729e-08 0.060936058470351516 0.02031189645523562 8.074670669787542e-11 10.092875181592607 -0.10663378516151156 GLVGIEFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLVGIEFK 8 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 13110200.0 5865700.0 3317000.0 3927500.0 False True 4877589.444569661 3299130.6626270483 4748722.091291756 1.0 0.676385476908076 0.9735797047409604 22.217736898345848 -10.415081434369226 8.2335568017887 1.0000026737512813 0.8249825912334063 0.31619388992215947 0.12132903544850288 5.954975622848966e-06 4.2310616633444153e-07 0.11747812744375102 0.03915877780862176 3.8451967416840905e-11 10.415081434369226 -0.17502008251787493 GLVK(ub)NIPQSTEILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLVKNIPQSTEILK 14 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 1 11995600.0 2698800.0 2459200.0 6837600.0 True False 2613128.0712484317 3441171.384558584 5046627.436396919 1.0 1.3168781975980808 1.9312591265325447 21.317346403215602 -6.960647526779344 0.4262094073784383 0.9745916810676569 2.2969593762000726 0.9997934666921775 0.005555894108542589 0.07947061399794349 0.0202825806093494 0.00798409938649376 0.05105914842547618 1.0948445811920689e-07 6.960647526779344 1.3223676951324157 GLVK(ub)NIPQSTEILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLVKNIPQSTEILK 14 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 1 8612800.0 2698800.0 3475400.0 2438600.0 True False 2244171.777111788 3456677.3303871076 2948499.985187547 1.0 1.5402908839874079 1.313847725588198 21.097751678649878 -10.113093772365113 4.539835700932979 0.9999598127808129 1.4270693046695149 0.8258630303961183 0.09244503234821567 3.7605965257780786e-05 7.34663090307728e-06 0.08951792368413958 0.02983650588742698 7.707370344427268e-11 10.113093772365113 0.42710949188870195 GLVLGIYSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLVLGIYSK 9 0 P28838-2;P28838;H0Y983 P28838-2 LAP3 Cytosol aminopeptidase 0 97711000.0 32279000.0 30866000.0 34566000.0 False True 42318081.59028066 26260913.11472564 30989441.900484987 1.0 0.6205601040468024 0.7322978910178773 25.334770891310892 -10.443975094319509 8.850749038840084 1.0000038791153574 0.6764289975323406 0.9179044376128771 0.04561676051115665 3.4917830676526036e-06 2.1929834538073683e-07 0.04416876798665475 0.01472274614730349 3.597699664538304e-11 10.443975094319509 -0.3235748815830167 GLVLGIYSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLVLGIYSK 9 0 P28838-2;P28838;H0Y983 P28838-2 LAP3 Cytosol aminopeptidase 0 95701000.0 40689000.0 19564000.0 35448000.0 False True 39397349.96703258 27376007.22491224 26163105.38279486 1.0 0.6948692551103129 0.6640828737132817 25.231595255365285 -13.999999999999986 0.3241853001412283 4.20764658641932 0.6582523106815692 0.999702646940534 0.0026144881263030747 18.344093021478518 0.1817757921721275 39.99775616214013 0.010085104132033623 1.0000000000000327e-14 13.999999999999986 -3.5493942757377503 GLVLGIYSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLVLGIYSK 9 0 P28838-2;P28838;H0Y983 P28838-2 LAP3 Cytosol aminopeptidase 0 226554000.0 60289000.0 90055000.0 76210000.0 False True 91462820.71629015 73983981.64707346 61147060.09597046 1.0 0.8088967852474772 0.6685455315842862 26.4466820768033 -6.974499594033692 0.10496489857723355 1.3197090253136023 0.15416273613739073 0.9999996856682761 7.594187844753587e-05 0.0748679426362581 0.003091446874482455 0.011873023614999933 0.022214817572318007 1.0604749296741071e-07 6.974499594033692 -1.1655462891762116 GLVLGIYSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLVLGIYSK 9 0 P28838-2;P28838;H0Y983 P28838-2 LAP3 Cytosol aminopeptidase 0 120951000.0 32279000.0 30384000.0 58288000.0 False True 44213418.60717555 29041534.413548276 44521574.87904181 1.0 0.6568488782008597 1.0069697454205961 25.397980952833784 -10.900337410055974 11.033984140860246 1.0133619000367733 0.8319093118107279 0.23507602093809 0.1429362454981826 0.045490442073299935 0.0004108840281758364 0.13399948586078925 0.04613247486532297 1.2579477131419464e-11 10.900337410055974 -0.18145258822604537 GLVLGIYSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLVLGIYSK 9 0 P28838-2;P28838;H0Y983 P28838-2 LAP3 Cytosol aminopeptidase 0 78562000.0 40689000.0 14479000.0 23394000.0 False True 33834706.32833171 14400998.753143527 28285577.23836522 1.0 0.42562801087724406 0.8359929879066251 25.01200053079956 -10.25902898910793 5.806166597830099 1.0000184097634501 0.6308104993919508 0.5190428586377887 0.16753080033849874 3.992601403016775e-05 5.095240224619628e-06 0.16221908035383903 0.054070333307315484 5.507709312805277e-11 10.25902898910793 -0.36920791037149936 GLVLGIYSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLVLGIYSK 9 0 P28838-2;P28838;H0Y983 P28838-2 LAP3 Cytosol aminopeptidase 0 253364000.0 60289000.0 112840000.0 80235000.0 False True 78045298.9738595 106560354.80566803 65633053.280622125 1.0 1.3653654506642272 0.8409610078193853 26.217808398895748 -6.719394656329371 1.7618908283055528 1.2224325072551123 0.8418281335604468 0.5094912824867657 0.15375864468374215 0.3564888359811895 2.1624795938652963 0.06930776521854358 0.17408629911204906 1.9081185063629704e-07 6.719394656329371 -0.3806043736946655 GLVLLRPPASLQYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLVLLRPPASLQYR 14 1 Q99575 Q99575 POP1 Ribonucleases P/MRP protein subunit POP1 0 6294500.0 2240500.0 2104500.0 1949500.0 False True 2937317.197032862 1790516.803276751 1747784.4409244768 1.0 0.6095755695317638 0.5950274770086137 21.486067638145464 GLVLLRPPASLQYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLVLLRPPASLQYR 14 1 Q99575 Q99575 POP1 Ribonucleases P/MRP protein subunit POP1 0 5872700.0 2240500.0 1392100.0 2240100.0 False True 3068873.3972358736 1330592.418940911 1711034.5163076755 1.0 0.43357683641800676 0.5575448364369804 21.549277699668355 -9.848125003980707 6.604866652418978 1.0000000124402213 0.49556083642771964 0.9566665321502482 0.05060972408009809 9.231144437348047e-09 1.6583147163779872e-09 0.04900265608992755 0.016334218209845455 1.4186491298721848e-10 9.848125003980707 -0.5044391760125017 GLVMVKPGSIKPHQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLVMVKPGSIKPHQK 15 2 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 38434000.0 11079000.0 10354000.0 17001000.0 False True 14524676.289188618 8809223.559575899 15241899.605107475 1.0 0.6065005088019075 1.0493796420408157 23.79200267491973 -6.672261928224865 1.9290381932135596 0.7493284279053722 1.0476217958066398 0.28927112812024935 0.1670619673157212 0.45592661618529545 3.272896271544072 0.06966245487142887 0.1855948274090328 2.126855926702291e-07 6.672261928224865 0.2982933679012676 GLVMVKPGSIKPHQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLVMVKPGSIKPHQK 15 2 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 39452800.0 8398000.0 2833800.0 28221000.0 False True 8131410.086832788 3965351.1180717787 20829073.488147505 1.0 0.4876584842883378 2.5615573763615824 22.955074124439008 -6.841333572210565 1.2760656361155394 0.727460334747448 2.6316395494259295 0.9267352662627284 0.23874685244006016 0.16725274243772514 0.5284361580203077 0.1466678772717396 0.33804788318881407 1.441008119148868e-07 6.841333572210565 1.9041792146784815 up GLVMVKPGSIKPHQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLVMVKPGSIKPHQK 15 2 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 39199500.0 6508600.0 27186000.0 5504900.0 False True 9874022.042396562 22334445.89481251 4416854.102116618 1.0 2.2619400482310072 0.4473206645834656 23.23520643502509 -6.7196938284287056 1.760543861202472 1.7679989867946762 0.45022094013158437 0.511036391695854 0.5310479912863105 0.35590223723083636 2.155728159259643 0.23952770712080831 0.6014919751447381 1.906804514899233e-07 6.7196938284287056 -1.3177780466630917 GLVMVKPGSIKPHQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLVMVKPGSIKPHQK 15 2 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 35620000.0 11079000.0 11641000.0 12900000.0 False True 15175205.698717369 11126662.128360853 9853285.683839558 1.0 0.7332132657220781 0.6493016226246193 23.85521273644262 -13.999999999999998 0.16191070089437057 2.3193323092056453 0.5685269963471653 0.9995314719168233 0.003236428251829552 12.022957492440222 0.12722034554641443 4.980838263355365 0.0737993678771671 1.0000000000000041e-14 13.999999999999998 -1.75080531285848 GLVMVKPGSIKPHQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLVMVKPGSIKPHQK 15 2 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 21607700.0 8398000.0 7821200.0 5388500.0 False True 6983309.094480803 7779065.643213355 6515210.436390994 1.0 1.1139512139540653 0.9329689332440165 22.735479399873284 -6.736510623118929 1.6993690517450228 1.0680730470966098 0.9329395320327107 0.5892086908632554 0.04788310680162831 0.3241728976891865 1.8367437501250243 0.022302953526607956 0.05494264343012976 1.8343802964615395e-07 6.736510623118929 -0.13513351506389903 GLVMVKPGSIKPHQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLVMVKPGSIKPHQK 15 2 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 38008600.0 6508600.0 11783000.0 19717000.0 False True 8425511.003686612 11127265.691910565 16128708.31350443 1.0 1.3206635997557643 1.914270636694588 23.00633275711754 -6.961528384871272 0.41332949552102366 0.9717990439788053 2.285284481213804 0.9998227515127418 0.005042514898734459 0.07915959557388628 0.019146832564519416 0.0076523169803742585 0.04950966783853183 1.0926262123558458e-07 6.961528384871272 1.3134854372349984 GLVNLQSGAPKPEENPSLNIQFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLVNLQSGAPKPEENPSLNIQFK 23 1 Q9Y2T2 Q9Y2T2 AP3M1 AP-3 complex subunit mu-1 0 14691200.0 6633300.0 3964400.0 4093500.0 False True 6422729.522384854 5547405.594072883 3021289.5476323217 1.0 0.863714651962029 0.4704058511420036 22.61475511145917 -6.952319441239902 0.5327788358001777 1.0060819291941614 0.31009901261765166 0.9993709185286951 0.005631619839189034 0.08256765281494861 0.032210586962512396 0.006257471078550777 0.03253656236368286 1.116042051524384e-07 6.952319441239902 -0.6959829165765097 down GLVNLQSGAPKPEENPSLNIQFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLVNLQSGAPKPEENPSLNIQFK 23 1 Q9Y2T2 Q9Y2T2 AP3M1 AP-3 complex subunit mu-1 0 26167200.0 4650300.0 13549000.0 7967900.0 False True 7054845.082468844 11131075.091179822 6393041.072545364 1.0 1.5777915689233675 0.9061915602416202 22.750182972315695 -6.679069601591781 1.9055040379242827 1.3658899999839802 0.9087861529457261 0.3197200158398307 0.24493337214390876 0.44060127963446083 3.0923316552890774 0.10317975685247603 0.27242343667875984 2.093776872767298e-07 6.679069601591781 -0.45710384703825413 GLVNLQSGAPKPEENPSLNIQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLVNLQSGAPKPEENPSLNIQFK 23 1 Q9Y2T2 Q9Y2T2 AP3M1 AP-3 complex subunit mu-1 0 9977800.0 2668800.0 2520800.0 4788200.0 False True 3655527.481608174 2409422.72082914 3657325.7760744635 1.0 0.6591176602970481 1.0004919384344222 21.801648167073154 -10.94782959744196 10.477279786487651 1.048344091697505 0.8298047993657351 0.24891921216186363 0.13936546545791825 0.08585110257544834 0.00042748518667402055 0.07361016112799185 0.04498001056291352 1.1276398173503066e-11 10.94782959744196 -0.21853929233176994 GLVPNLQTFCNLAIGCHRPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLVPNLQTFCNLAIGCHRPK 20 1 G3V325;O75127 G3V325 ATP5J2-PTCD1;PTCD1 Pentatricopeptide repeat-containing protein 1, mitochondrial 0 8670250.0 713050.0 2534900.0 5422300.0 False True 976683.854451703 2422899.736206677 4141664.415773889 1.0 2.4807410557297067 4.240537403066791 19.897532122172773 -6.968837058101672 0.28459405992832393 0.6331386398032892 6.142104048739288 0.9999718376957374 0.007029289935071913 0.07668187147653964 0.010374394558684944 0.03166913765356805 0.16061157696627512 1.0743924354362775e-07 6.968837058101672 5.508965408935999 GLVQALGLSNFNSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLVQALGLSNFNSR 14 0 P14550 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 34537200.0 10557000.0 15258000.0 8722200.0 False True 13840329.234133413 12981565.875218177 7819710.413250298 1.0 0.9379521003880942 0.5649945374106496 23.72237492646378 -6.935797179604478 0.6975698188349676 1.0046416744290723 0.47574737990956695 0.9975598956291818 0.00949003186572269 0.08973753194855472 0.06374026567606902 0.00896641914666747 0.03273786854446367 1.1593186445651453e-07 6.935797179604478 -0.5288942945195053 GLVQALGLSNFNSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLVQALGLSNFNSR 14 0 P14550 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 97240000.0 37584000.0 24527000.0 35129000.0 False True 36390916.49244144 34320759.00661531 25927661.052589674 1.0 0.9431133457093308 0.7124761767946945 25.117075049616187 -6.9445650277567825 0.6156333537210763 1.0025336269132719 0.6409284092025117 0.9987027272665661 0.004477719485220519 0.08574444427948633 0.04558037700217457 0.00452754605039389 0.01948725147506621 1.1361481672575778e-07 6.9445650277567825 -0.36160521771076015 GLVQALGLSNFNSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLVQALGLSNFNSR 14 0 P14550 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 37512200.0 6329000.0 21444000.0 9739200.0 False True 9601555.711877787 17617150.657263298 7814242.851157003 1.0 1.8348225210493405 0.8138517429514308 23.1948367497385 -6.689355671927147 1.868467809668121 1.523710555022312 0.8173927748599706 0.36737745846348235 0.3531206605265118 0.41813480315803886 2.8296938931053024 0.1512081445672996 0.3941111223688124 2.0447693565350142e-07 6.689355671927147 -0.7063177801623414 GLVQALGLSNFNSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLVQALGLSNFNSR 14 0 P14550 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 98366000.0 10557000.0 40405000.0 47404000.0 False True 14460208.192197772 38619773.498532794 36208151.51602565 1.0 2.6707619271602665 2.5039854914096127 23.78558498798667 -10.24861564492054 5.023985738578238 0.99973347840179 2.5873737092858717 0.9917890841610387 0.06808619478813152 0.00020328855359099635 3.040369721771983e-05 0.06593460291296706 0.021974724876287283 5.6413670174132564e-11 10.24861564492054 1.5876402308840816 GLVQALGLSNFNSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLVQALGLSNFNSR 14 0 P14550 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 61869000.0 37584000.0 9790000.0 14495000.0 False True 31252761.253508724 9737259.326837143 17525837.48269234 1.0 0.3115647685608563 0.5607772491054602 24.897480325050463 -10.25982212342225 5.568736959696622 1.0000425884176891 0.4361710088333605 0.8722022422903792 0.10174056914465322 5.379927710855013e-05 7.150928245024475e-06 0.09851729370489434 0.03283662749423345 5.497659986862831e-11 10.25982212342225 -0.5638715795843285 GLVQALGLSNFNSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLVQALGLSNFNSR 14 0 P14550 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 34505000.0 6329000.0 15557000.0 12619000.0 False True 8193015.263241327 14691239.274297928 10322471.48187413 1.0 1.7931419388672991 1.2599111743617508 22.96596307183095 -10.281688181374786 4.467131363547501 0.9996744433755262 1.526526556618585 0.5652205315666902 0.2176905480459331 154257322.67623395 278.1770431507592 516556.23544993345 0.07452126482320484 5.2277139835565854e-11 10.281688181374786 0.5268521132430588 GLVQALQTK(ub)VTQQGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLVQALQTKVTQQGLK 16 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 33625700.0 5222700.0 12766000.0 15637000.0 True False 6847010.276698753 10861362.561478265 14019033.24069559 1.0 1.586292720845018 2.0474678252498237 22.707042747101266 -6.9738231273371944 0.13928690749256986 0.37596160852367017 3.2698213043470843 0.9999989481534404 0.00043957612043924 0.07508053671766618 0.004215399114981807 0.02626247616504461 0.060255011812538874 1.062128036017501e-07 6.9738231273371944 2.893859695823414 GLVQALQTK(ub)VTQQGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLVQALQTKVTQQGLK 16 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 60294100.0 21088000.0 16509100.0 22697000.0 True False 20418572.982987616 23101269.723819166 16751974.804595323 1.0 1.131385123880436 0.8204282845110069 24.283378706612044 -6.791887221732134 1.4885637192512748 1.0732493209051572 0.8169359978037537 0.8074725149634893 0.05592449584441006 0.23253354646437838 1.0178124566786948 0.029567224341727254 0.06913677087994691 1.614777830408795e-07 6.791887221732134 -0.25631332310140353 GLVQALQTK(ub)VTQQGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLVQALQTKVTQQGLK 16 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 61770500.0 13637000.0 6437500.0 41696000.0 True False 20688325.998242583 5288677.828582923 33454767.323994022 1.0 0.2556358513024293 1.6170843076832757 24.302313578054243 -6.758239916568737 1.6189775909197206 0.5666850531561859 1.6216492183855893 0.6837728535604644 0.31300902775818495 0.2858916819943393 1.47646248071841 0.15257066212292444 0.3673086352908969 1.7448579776741105e-07 6.758239916568737 1.0549641652294035 GLVQALQTK(ub)VTQQGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLVQALQTKVTQQGLK 16 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 23024100.0 5222700.0 9216300.0 8585100.0 True False 7153673.328160601 8809093.39177151 6557476.195684566 1.0 1.231408395054092 0.9166586024931987 22.770252808624157 -6.709687886824134 1.796406201986827 1.1423097616358218 0.917407263167418 0.46360219464550245 0.09751881764198793 0.375691160651885 2.3631627837696634 0.04320404199781773 0.10979648028008043 1.9512463926627657e-07 6.709687886824134 -0.2249024984684037 GLVQALQTK(ub)VTQQGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLVQALQTKVTQQGLK 16 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 53160500.0 21088000.0 18864500.0 13208000.0 True False 17535606.35680059 18762873.194189917 15969731.733107958 1.0 1.0699871343150547 0.91070313784243 24.06378398204632 -6.78725276459643 1.5071067985243427 1.0392557218204206 0.9091305750943558 0.7923619848343941 0.029703737825718706 0.2394690583260888 1.0745412393684628 0.015515350403510165 0.03640213122882356 1.6321017686121553e-07 6.78725276459643 -0.1301251467260648 GLVQALQTK(ub)VTQQGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLVQALQTKVTQQGLK 16 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 36001300.0 13637000.0 8745300.0 13619000.0 True False 17653365.325457722 8258616.3672634605 11140481.742740616 1.0 0.46782107632213343 0.6310684414758614 24.073439900146692 -10.914693278557875 11.43996075267068 1.0476258237863454 0.5494447588989975 0.9103658520755505 0.06664545774673944 0.03479357286795225 0.0002594519891350885 0.02773419396928658 0.021509728996124338 1.217045238093131e-11 10.914693278557875 -0.4981810648873479 GLVSGGLYESHVGCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLVSGGLYESHVGCR 15 0 P07858 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 5863500.0 1426900.0 2905000.0 1531600.0 False True 1954463.4905225919 2776647.494449642 1169867.6242921453 1.0 1.4206699219064007 0.5985620248037182 20.898341204586345 -6.767627434109701 1.5837157358406204 1.2420164086507035 0.5943662282435497 0.7213431907681911 0.17718527728311617 0.2702805550399198 1.3375308059331854 0.08820881862485536 0.21041858310020894 1.7075466047601847e-07 6.767627434109701 -0.6476501804071538 GLVTLK(ub)HSATPFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLVTLKHSATPFLK 14 1 P08243-2;P08243;P08243-3;F8WEJ5;C9J057 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 52747900.0 2701500.0 6633400.0 43413000.0 True False 4098373.0061048917 5449617.943009239 34832401.52140615 1.0 1.3297027710487912 8.499080359332883 21.966619863963317 -6.916508841850556 0.850208184059278 0.8210469545119831 9.567239585218395 0.9931550744560997 0.28626051001247577 0.10026996745835834 0.11657742096163108 0.24218682184936483 0.7029336206835882 1.211968013929652e-07 6.916508841850556 8.746192630706412 up GLVTLK(ub)HSATPFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLVTLKHSATPFLK 14 1 P08243-2;P08243;P08243-3;F8WEJ5;C9J057 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 6855900.0 1679900.0 1945100.0 3230900.0 True False 2301004.427590513 1859159.0504144563 2467827.9624742004 1.0 0.8079771721088197 1.0725003102485882 21.13383232892126 -6.712019311033517 1.7880275423667886 0.8821917159777894 1.0719156214800039 0.4746521291038448 0.08089246053322732 0.3710448974592291 2.3136143872472807 0.03598588315760346 0.09119718082217981 1.940799577442724e-07 6.712019311033517 0.1897239055022144 GLVTLK(ub)HSATPFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLVTLKHSATPFLK 14 1 P08243-2;P08243;P08243-3;F8WEJ5;C9J057 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 11524500.0 2554100.0 2860900.0 6109500.0 True False 2123847.3158148895 2845487.763855812 7386968.202863665 1.0 1.3397798149929812 3.4781069937833045 21.018248623303162 -6.934834391431465 0.7059914674073533 0.9725710712710957 3.97650812707218 0.9974058561786385 0.055868639336465555 0.09020431046290033 0.0659469584419382 0.052451496437654836 0.18860468404054323 1.1618915909640538e-07 6.934834391431465 3.0039370558010843 up GLVTLK(ub)HSATPFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLVTLKHSATPFLK 14 1 P08243-2;P08243;P08243-3;F8WEJ5;C9J057 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 37209300.0 2701500.0 6698800.0 27809000.0 True False 3497145.004526222 6326005.891281544 22748047.34443597 1.0 1.8089058026172877 6.504748105953295 21.737746186055766 -6.936537351052996 0.6910241922983508 0.9428259185223015 7.651707776858664 0.997674304607525 0.11703718956584726 0.0893823920526775 0.06207268670563226 0.11113378181375058 0.4107045115209241 1.1573444915818556e-07 6.936537351052996 6.708881858336362 GLVVLGFPCNQFGHQENAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLVVLGFPCNQFGHQENAK 19 0 A0A087WUQ6;P07203 A0A087WUQ6 GPX1 Glutathione peroxidase;Glutathione peroxidase 1 0 28866200.0 10584000.0 10784000.0 7498200.0 False True 13875726.495601788 9175069.235702764 6722358.19181323 1.0 0.6612316291050419 0.4844689172811259 23.726059973271635 -13.613780626516371 0.08562855799641793 2.6736631227446535 1.2203183837922196e-19 0.9998741612511242 0.0023994849337395804 10.674052441123798 0.07978884384598361 3.422761874123945 0.42117817218305176 2.4334328891750164e-14 13.613780626516371 -2.6736631227446535 GLVVLGFPCNQFGHQENAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLVVLGFPCNQFGHQENAK 19 0 A0A087WUQ6;P07203 A0A087WUQ6 GPX1 Glutathione peroxidase;Glutathione peroxidase 1 0 22778400.0 10833000.0 4667600.0 7277800.0 False True 10489112.344684402 6531397.021212447 5371525.850679991 1.0 0.622683484224705 0.5121049021275985 23.322389257273787 -13.999999999999998 0.17206419380955212 2.9133188873520433 0.4166749336219262 0.9995098915788634 0.004624024239225829 12.112267242750706 0.13139427216700153 7.736784350230249 0.08848673268510611 1.0000000000000041e-14 13.999999999999998 -2.496643953730117 GLVVLGFPCNQFGHQENAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLVVLGFPCNQFGHQENAK 19 0 A0A087WUQ6;P07203 A0A087WUQ6 GPX1 Glutathione peroxidase;Glutathione peroxidase 1 0 45872000.0 10584000.0 15494000.0 19794000.0 False True 14497190.82184534 14809423.848193722 15119064.870226374 1.0 1.021537484757246 1.0428961759573416 23.789270034794527 -6.9712285531677125 0.22694485648083537 0.990974642558404 1.0740670662654141 0.9999903328645162 5.414244497306064e-05 0.0759061129237917 0.007588651383754929 0.0005613740958409232 0.002134129594694428 1.0684924230826893e-07 6.9712285531677125 0.0830924237070102 GLVVLGFPCNQFGHQENAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLVVLGFPCNQFGHQENAK 19 0 A0A087WUQ6;P07203 A0A087WUQ6 GPX1 Glutathione peroxidase;Glutathione peroxidase 1 0 21132900.0 10833000.0 2557700.0 7742200.0 False True 9008119.483271083 2543921.1624362986 9361058.224111801 1.0 0.2824031327693418 1.0391800687697537 23.102794532708064 -9.692151604396678 13.908546082114357 1.0000013798607328 0.6607916007695478 0.21128023832344756 0.3089528903856755 0.0 0.0 0.29914234980612764 0.09971411660204253 2.0316476754530514e-10 9.692151604396678 -0.339209779091185 GLVVLGFPCNQFGHQENAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLVVLGFPCNQFGHQENAK 19 0 A0A087WUQ6;P07203 A0A087WUQ6 GPX1 Glutathione peroxidase;Glutathione peroxidase 1 0 14822800.0 4820700.0 5875000.0 4127100.0 False True 6240491.180203419 5548051.085459937 3376010.1476220535 1.0 0.8890407702297385 0.5409846837588203 22.573228155359704 -6.950444102781033 0.5539464923568795 1.0047047020817181 0.4088585066495777 0.999235675659386 0.005406189463980765 0.08330790376035255 0.03522810803277304 0.0058384401946933295 0.028896359359655927 1.1208716821210539e-07 6.950444102781033 -0.5958461954321405 GLVYIQQTDDSLIHFCWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLVYIQQTDDSLIHFCWK 18 0 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 0 122108000.0 38928000.0 49691000.0 33489000.0 False True 50393063.385599375 46925652.16810038 27394345.626157563 1.0 0.9311926883474628 0.543613421881908 25.586721824366762 -6.937186656607143 0.6852436262158009 1.0046343459253855 0.4472160251081707 0.9977715799200634 0.009483628514502152 0.0890741418786743 0.06063380668752772 0.009045468098527078 0.033792442010532615 1.1556154603298715e-07 6.937186656607143 -0.5574183208172148 GLYGGSSYVDFLCCVHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GLYGGSSYVDFLCCVHK 17 0 O94855;O94855-2;E9PDM8 O94855 SEC24D Protein transport protein Sec24D 0 6217000.0 1644600.0 2405200.0 2167200.0 False True 2156086.5263290573 2046353.5353961682 1942958.9332503346 1.0 0.9491054790274489 0.9011507235557968 21.03998364565253 -6.9718446886167245 0.209495858654847 1.0252691470096937 0.8236491039088195 0.9999933986424601 0.00010353909670351171 0.07570853346198873 0.006845403184313685 0.0014417877587261136 0.004975084399438331 1.0669776230680933e-07 6.9718446886167245 -0.20162004310087422 GLYGGSSYVDFLCCVHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GLYGGSSYVDFLCCVHK 17 0 O94855;O94855-2;E9PDM8 O94855 SEC24D Protein transport protein Sec24D 0 7253700.0 1644600.0 2156900.0 3452200.0 False True 2252653.063643886 2061601.0260855195 2636861.4602907714 1.0 0.9151879884915252 1.1705581755343146 21.10319370717542 -6.817181747762887 1.3840088170246667 0.9541523117344778 1.1758039001181468 0.8777801335918356 0.037125854809145986 0.19717031516088881 0.7428586488057474 0.02108359627869561 0.04863495026701116 1.5234150868713837e-07 6.817181747762887 0.22165158838366905 GLYK(ub)EGQNWLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLYKEGQNWLEK 12 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 93758500.0 0.0 9358500.0 84400000.0 True False 0.0 13095397.853932781 62293108.05427345 0.0 GLYK(ub)EGQNWLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLYKEGQNWLEK 12 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 548990400.0 17572400.0 144678000.0 386740000.0 True False 26658615.51452069 118859080.52562658 310300669.4858364 1.0 4.458561640640535 11.639789370037564 24.668098521825204 -6.959305503151252 0.44511575522179025 0.7565039886769539 15.624223215936553 0.9997435617217522 0.07096327682827931 0.07995017888024918 0.02205527078432315 0.0953158328096973 0.5944653856575942 1.0982330189206673e-07 6.959305503151252 14.867719227259599 GLYK(ub)EGQNWLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GLYKEGQNWLEK 12 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 85960500.0 0.0 8136500.0 77824000.0 True False 0.0 8092667.059531204 94096638.58248004 0.0 GLYK(ub)EGQNWLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLYKEGQNWLEK 12 1 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 1 588080400.0 17572400.0 148118000.0 422390000.0 True False 22747818.203789238 139875103.09381366 345519354.0873934 1.0 6.148945883105125 15.18912060013906 24.439224843917653 -6.962509998775906 0.398484337787619 0.49466592636356865 21.172684853932477 0.9998522621833646 0.07128567960538623 0.07881640009049826 0.017905575147678845 0.11634805531752185 0.7578511381893371 1.0901593933212214e-07 6.962509998775906 20.678018927568907 GLYK(ub)QGQHWLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GLYKQGQHWLEK 12 1 H0YNG3;P67812-2;P67812-4;P67812;P67812-3;H0YKT4 H0YNG3 SEC11A Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11A 1 143011400.0 5620400.0 44761000.0 92630000.0 True False 8526557.706278708 36773049.830710776 74321639.89882872 1.0 4.312766194455258 8.716488231129947 23.02353199171121 -6.967186782909419 0.31829370994713885 0.38470759004395877 12.786231039759533 0.9999513869255056 0.022037514048894365 0.07722651712726442 0.0122832849438397 0.06721950976381404 0.38795124369399303 1.0784827847740649e-07 6.967186782909419 12.401523449715574 GLYK(ub)QGQHWLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GLYKQGQHWLEK 12 1 H0YNG3;P67812-2;P67812-4;P67812;P67812-3;H0YKT4 H0YNG3 SEC11A Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11A 1 110017400.0 5620400.0 42633000.0 61764000.0 True False 7275718.594647113 40260436.07258107 50523585.75215731 1.0 5.53353398002521 6.944136870456822 22.79465831380366 -9.171046141122245 0.4195470053368252 3.440257930988706e-16 7.11974927279625 0.9976987241928083 0.1216495302387881 0.5795216572837297 0.1624351117112081 1.351026219802328 0.33714319011909233 6.744563670432286e-10 9.171046141122245 7.11974927279625 GLYMANDLK(ub)LLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GLYMANDLKLLR 12 1 Q9Y2Q3;Q9Y2Q3-3;Q9Y2Q3-2;E9PFN5;C9JNT3 Q9Y2Q3 GSTK1 Glutathione S-transferase kappa 1 1 8057600.0 3692800.0 3008700.0 1356100.0 True False 3575574.0853365236 4210089.600163226 1000896.7278720392 1.0 1.1774583604431128 0.2799261612216986 21.76974346536211 -6.855338877834265 1.208949797940865 1.0953330842704947 0.24015536599774878 0.9477273546039799 0.0887310566311726 0.15168625000505825 0.4239346921359374 0.057340256667337414 0.13323251329769253 1.3952792067226205e-07 6.855338877834265 -0.8551777182727459 down GMAAAGNYAWVNR ddPTM_RPMI8226_Bortezomib_1h_R1 2 GMAAAGNYAWVNR 13 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 332822200.0 71558200.0 152827000.0 108437000.0 False True 93813493.17059453 130025807.31498004 97216979.44115268 1.0 1.3860032594515532 1.0362792830277527 26.48329210433281 -10.613642195643859 7.058743830028706 0.9996043031101034 1.2111412712392222 0.32705143337965137 0.14277421550924096 0.000890731335729266 4.875366301005216e-05 0.13849390048704593 0.04608017991125992 2.434208666775287e-11 10.613642195643859 0.21153696812911882 GMAAAGNYAWVNR ddPTM_RPMI8226_Bortezomib_2h_R1 2 GMAAAGNYAWVNR 13 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 114571600.0 41312700.0 28847500.0 44411400.0 False True 40001250.9519287 40366457.18772513 32778722.026558716 1.0 1.009129870369187 0.8194424235869618 25.253541782059635 -6.895596234202066 0.9887124267019579 1.0088673972436926 0.801221807022284 0.9842443308119705 0.010963951436436038 0.11471898873908594 0.19627463916832152 0.008381120942767216 0.021361719431584256 1.2717559137250455e-07 6.895596234202066 -0.2076455902214086 GMAAAGNYAWVNR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GMAAAGNYAWVNR 13 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 808404100.0 328962100.0 344351000.0 135091000.0 False True 499059556.0509261 282898873.62335664 108390204.63751128 1.0 0.5668639547991913 0.2171889172811485 28.89463675119921 -7.896443989985671 0.3072821444552778 1.110132816768876 7.349499742533651e-21 0.99922384765145 0.008920228258830537 0.10949110459342963 0.05413848108264763 0.04858596610940171 0.08614489320023137 1.2692758296317728e-08 7.896443989985671 -1.110132816768876 down GMAAAGNYAWVNR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GMAAAGNYAWVNR 13 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 336631800.0 71558200.0 133534900.0 131538700.0 False True 98015200.32764302 127634886.57713702 100471968.18456326 1.0 1.302194824379096 1.025065172021358 26.546502165855703 -10.494022383422571 3.4009265076033746 0.9968935647337173 1.163629997927009 0.3173291383574911 0.11313770708372925 13250000.460480822 13636074.027724294 273470.566831195 0.03873001049766694 3.206104078492089e-11 10.494022383422571 0.1667364331932918 GMAAAGNYAWVNR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GMAAAGNYAWVNR 13 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 140893400.0 41312700.0 83534100.0 16046600.0 False True 34353340.51292657 83084085.22307935 19401869.868904483 1.0 2.4185154626175653 0.5647738932871431 25.03394705749391 -6.70221273429763 1.8229078262868217 1.8789160169926926 0.5700387094533055 0.4281318289227366 0.5985327547136585 0.3909300862906438 2.527045570417554 0.26178755300256795 0.6714333303554352 1.9851222891966608e-07 6.70221273429763 -1.3088773075393871 GMAAAGNYAWVNR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GMAAAGNYAWVNR 13 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 847072500.0 328962100.0 284711000.0 233399400.0 False True 425847923.26242995 268866582.56891656 190923104.08008006 1.0 0.6313676030380141 0.44833635119648846 28.66576307329166 -13.999999999999998 0.09127977132594724 2.877514239635225 3.533826827434446e-08 0.9998367209874525 0.0029316043060705842 12.14298856140026 0.08802658568194502 4.404871604740447 0.40207227067441464 1.0000000000000041e-14 13.999999999999998 -2.877514204296957 GMADIDIQDDKWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GMADIDIQDDKWR 13 1 Q5JSD8;H0Y468;A0A1B0GTZ9;A0A1B0GV73;A0A087WW76;A0A452Q6Z5;Q5T5U3 Q5JSD8 ARHGAP21 Rho GTPase-activating protein 21 0 9243540.0 1911700.0 4847640.0 2484200.0 False True 2506257.212929137 4124391.0079527223 2227158.81412905 1.0 1.6456375613309155 0.8886393633661022 21.25710305292849 -6.6808667274862215 1.8991259967965382 1.408201289844815 0.8915269235312457 0.32788990858502065 0.27358784929736163 0.43663886444409933 3.045586285272138 0.11557163989822741 0.30443889397492185 2.0851306516900767e-07 6.6808667274862215 -0.5166743663135693 GMADIDIQDDKWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GMADIDIQDDKWR 13 1 Q5JSD8;H0Y468;A0A1B0GTZ9;A0A1B0GV73;A0A087WW76;A0A452Q6Z5;Q5T5U3 Q5JSD8 ARHGAP21 Rho GTPase-activating protein 21 0 7006500.0 1917000.0 2077200.0 3012300.0 False True 1856145.8843127463 2906636.792454899 2223288.262937061 1.0 1.5659527718270407 1.1977982343560523 20.82387867327214 -10.161464261654439 4.818489515312157 0.9999652106645452 1.3818755030932872 0.5892500007364789 0.15029846055504167 5.617621131987656e-05 9.776159147120613e-06 0.14553909584028663 0.04850861955667133 6.895023303842977e-11 10.161464261654439 0.38191029242874197 GMADIDIQDDKWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GMADIDIQDDKWR 13 1 Q5JSD8;H0Y468;A0A1B0GTZ9;A0A1B0GV73;A0A087WW76;A0A452Q6Z5;Q5T5U3 Q5JSD8 ARHGAP21 Rho GTPase-activating protein 21 0 33365900.0 14345400.0 11902000.0 7118500.0 False True 21763020.589219715 9777995.109249555 5711525.3548506135 1.0 0.44929402465818885 0.26244175671458997 24.375375472943865 -13.999999999999977 0.1509089030015273 3.6666885004325604 0.05899997295011102 0.9995632342522903 0.0065430796290920305 11.961261602666774 0.1223902216104064 9.350837994974443 0.18353415671737974 1.0000000000000532e-14 13.999999999999977 -3.6076885274824493 GMADIDIQDDKWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GMADIDIQDDKWR 13 1 Q5JSD8;H0Y468;A0A1B0GTZ9;A0A1B0GV73;A0A087WW76;A0A452Q6Z5;Q5T5U3 Q5JSD8 ARHGAP21 Rho GTPase-activating protein 21 0 10211000.0 1911700.0 5210900.0 3088400.0 False True 2618507.1517499797 4980665.207858051 2358983.5275945803 1.0 1.9021010519407644 0.9008887090562435 21.32031311445138 -6.669331221263355 1.9398869148792006 1.576138390978963 0.9049584399635505 0.2760612749034108 0.383251849318872 0.4626326742032757 3.3558128706407078 0.15909205630906245 0.4254029195127243 2.1412569162087416e-07 6.669331221263355 -0.6711799510154125 GMADIDIQDDKWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GMADIDIQDDKWR 13 1 Q5JSD8;H0Y468;A0A1B0GTZ9;A0A1B0GV73;A0A087WW76;A0A452Q6Z5;Q5T5U3 Q5JSD8 ARHGAP21 Rho GTPase-activating protein 21 0 37017500.0 14345400.0 14669200.0 8002900.0 False True 18570403.090109356 13852846.124736842 6546454.31668837 1.0 0.7459636744296037 0.35252085185889304 24.146501795036315 -6.964720143178263 0.36282472753324224 1.0328275336041834 0.05211479786371579 0.9999072576152603 0.0025651806509122493 0.07805607103184344 0.015195681890838995 0.005249549244649046 0.0335490649467236 1.0846256152745084e-07 6.964720143178263 -0.9807127357404677 down GMAEGHHAVNIEGLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 GMAEGHHAVNIEGLK 15 0 Q5W0W3;Q14678-2;Q14678 Q5W0W3 KANK1 KN motif and ankyrin repeat domain-containing protein 1 0 348185900.0 97702800.0 154068300.0 96414800.0 False True 128089316.95526108 131081910.19352967 86438721.37206715 1.0 1.023363332004603 0.6748316208310986 26.932574914572616 -6.890864241330233 1.0172759126547533 1.0183409148799385 0.644344345334347 0.9814450096186923 0.021669193409041967 0.11844395887750613 0.21778385820705362 0.016212007588716215 0.040543828869626514 1.285688498073224e-07 6.890864241330233 -0.37399656954559146 GMAEGHHAVNIEGLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 GMAEGHHAVNIEGLK 15 0 Q5W0W3;Q14678-2;Q14678 Q5W0W3 KANK1 KN motif and ankyrin repeat domain-containing protein 1 0 278500700.0 70616300.0 84089800.0 123794600.0 False True 68374624.20990838 117667295.66251406 91369080.50160618 1.0 1.7209205465068211 1.3363010262565451 26.026957663019964 -10.173008488868003 4.505703075215476 0.9999006987626775 1.5286107863919545 0.7157908719442005 0.1570202616561373 110089750.70105685 21.576026332646588 113418.25408214357 0.05375221205381275 6.71415729076951e-11 10.173008488868003 0.528710087629277 GMAEGHHAVNIEGLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 GMAEGHHAVNIEGLK 15 0 Q5W0W3;Q14678-2;Q14678 Q5W0W3 KANK1 KN motif and ankyrin repeat domain-containing protein 1 0 1159599400.0 584071000.0 369591500.0 205936900.0 False True 886078408.3097135 303635009.19343054 165233381.44965032 1.0 0.3426728451409236 0.18647715585898333 29.7228591263606 -13.99999999999993 0.20187321219730542 4.680316006628317 0.08688846599250193 0.9994871061034241 0.00798308375790834 12.568538028577896 0.14245818146387065 18.278791412757883 0.09808567298051708 1.0000000000001595e-14 13.99999999999993 -4.593427540635815 GMAEGHHAVNIEGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GMAEGHHAVNIEGLK 15 0 Q5W0W3;Q14678-2;Q14678 Q5W0W3 KANK1 KN motif and ankyrin repeat domain-containing protein 1 0 303869300.0 97702800.0 103114000.0 103052500.0 False True 133826165.47889188 98558082.52760081 78713621.93285851 1.0 0.7364634724077644 0.588178116373467 26.995784976095507 -13.999999999222595 0.0671725073804808 2.5624965035562424 0.01721492216467163 0.9999336828650004 0.0013868808601112685 12.389862093572937 0.0689854051167063 3.089083096275662 0.5283532158940223 1.0000000017900407e-14 13.999999999222595 -2.5452815813915706 GMAEGHHAVNIEGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GMAEGHHAVNIEGLK 15 0 Q5W0W3;Q14678-2;Q14678 Q5W0W3 KANK1 KN motif and ankyrin repeat domain-containing protein 1 0 261718680.0 70616300.0 157720200.0 33382180.0 False True 58720582.28251787 156870529.97759134 40362239.49623884 1.0 2.6714743600949338 0.6873610227849423 25.80736293845424 -6.683351195163537 1.8895567559916133 2.0544042802044076 0.6946507464264072 0.3394832795718994 0.7079069363261694 0.4312566259544842 2.9796874953519032 0.3002686339605201 0.7886773725401246 2.0732363028737408e-07 6.683351195163537 -1.3597535337780005 GMAEGHHAVNIEGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GMAEGHHAVNIEGLK 15 0 Q5W0W3;Q14678-2;Q14678 Q5W0W3 KANK1 KN motif and ankyrin repeat domain-containing protein 1 0 1187991000.0 584071000.0 344659000.0 259261000.0 False True 756091423.2606462 325478423.67038983 212078158.24250486 1.0 0.43047495799749097 0.2804927442873472 29.49398544845305 -13.999999999999941 0.18730315375807458 4.025096040216754 0.1699248411905788 0.9994911199282085 0.0069916535839738385 12.308031806648108 0.1372394224905894 13.576968217090936 0.105400551876256 1.000000000000135e-14 13.999999999999941 -3.855171199026175 GMAFTLQER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GMAFTLQER 9 0 A0A1W2PQT3;A0A1W2PPH1;A0A1W2PQY8;P23368;A0A1W2PQF8;P23368-2;A0A1W2PR68;A0A1W2PRS2;A0A1W2PRY9;A0A1W2PQH4;A0A1W2PRH1 A0A1W2PQT3 ME2 NAD-dependent malic enzyme, mitochondrial 0 6716500.0 1269500.0 1623400.0 3823600.0 False True 1664326.793855488 1381195.047963637 3427970.5505610835 1.0 0.8298821199435457 2.059673955389515 20.666507306640465 -6.871929748943385 1.1238996095549283 0.9025775678754858 2.1343683187559495 0.9665683783839718 0.09948185825476873 0.13501481352165012 0.3175788045624444 0.06861355008350292 0.16300449146977455 1.3429821830715188e-07 6.871929748943385 1.2317907508804637 up GMALFFYSHACNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GMALFFYSHACNR 13 0 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 0 9190800.0 2808700.0 3340400.0 3041700.0 False True 3682232.8994894954 2842025.34077722 2726974.0620466694 1.0 0.7718211797986049 0.7405762037552641 21.812149448676927 -13.99999999996574 0.2801569891717706 2.861243402789663 0.7311846490674455 0.9996055229762711 0.0022966657624191216 15.406615769281226 0.1676716985152287 16.431371059724135 0.012350370144526862 1.000000000078888e-14 13.99999999996574 -2.1300587537222175 GMALFFYSHACNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GMALFFYSHACNR 13 0 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 0 38976800.0 9864800.0 11818000.0 17294000.0 False True 14965622.813482689 9708985.565544555 13875833.319770517 1.0 0.6487525234698303 0.9271804784007807 23.835148983891244 -10.05197995345444 7.418301696141945 1.0000000196655348 0.7879665009353054 0.43606490962567757 0.11366773661791003 3.695384524637803e-08 4.642563386237813e-09 0.11005832257053223 0.03668610424352137 8.871969631082963e-11 10.05197995345444 -0.21203351873022935 GMALFFYSHACNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GMALFFYSHACNR 13 0 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 0 12580300.0 2808700.0 2936300.0 6835300.0 False True 3847152.292263519 2806564.5569543773 5220942.917422371 1.0 0.7295174050162441 1.3570928626666259 21.875359510199818 -6.7895700551628515 1.4979654492682375 0.8487426849756253 1.363696391627148 0.7999522628582252 0.11495593413946718 0.23599416432280224 1.0461351399938321 0.06040480070883091 0.14147201745934354 1.6234164593409665e-07 6.7895700551628515 0.5149537066515227 GMALFFYSHACNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GMALFFYSHACNR 13 0 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 0 35214800.0 9864800.0 13386000.0 11964000.0 False True 12770178.06427919 12641057.332760293 9786674.761006592 1.0 0.989888885584135 0.7663694830052473 23.606275305983694 -6.916361958492391 0.8512670122745282 1.0056075551681445 0.7331770680632085 0.9931093320179245 0.008950997074251774 0.10036000787830493 0.11705407708832041 0.007567150989251448 0.021935645094840583 1.2123779846903613e-07 6.916361958492391 -0.272430487104936 GMATCFAYGQTGSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GMATCFAYGQTGSGK 15 0 O00139-2;O00139-1;O00139-5;O00139;O00139-4 O00139-2 KIF2A Kinesin-like protein KIF2A 0 12993900.0 3048400.0 3611500.0 6334000.0 False True 3996481.920747591 3072678.277516739 5678618.440018275 1.0 0.7688457844798549 1.420904323509618 21.930299132121995 -6.81088727946875 1.4109034118800632 0.8741563744404628 1.4325338379110784 0.8621100816184631 0.10023555221715358 0.2055912956340921 0.8064636814370468 0.05586063067731392 0.12915971019986072 1.5456555602408225e-07 6.81088727946875 0.5583774634706156 GMDK(ub)LIVDGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 GMDKLIVDGR 10 1 Q99832;F8WBP8;A0A0D9SG95 Q99832 CCT7 T-complex protein 1 subunit eta 1 202019600.0 56664600.0 100570000.0 44785000.0 True False 74287839.34076698 85565348.0187896 40151077.80805469 1.0 1.1518082741145745 0.5404798169438879 26.146622730175316 -6.840974631531971 1.277859763573024 1.0807494223011307 0.5199808660461593 0.9261225874607536 0.07064156468710205 0.16765840437081286 0.5313862358608781 0.043340766866295434 0.09987635332452764 1.4421995923504697e-07 6.840974631531971 -0.5607685562549714 GMDK(ub)LIVDGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 GMDKLIVDGR 10 1 Q99832;F8WBP8;A0A0D9SG95 Q99832 CCT7 T-complex protein 1 subunit eta 1 269067700.0 99218500.0 111155200.0 58694000.0 True False 96068863.026961 155540051.02671024 43320280.61774314 1.0 1.6190474845430314 0.4509294609387189 26.517565577671277 -6.762693637866915 1.6020795252440772 1.3583603413647636 0.4460433489852515 0.7019943089443115 0.2604851573039597 0.278398103109977 1.4088467030798086 0.1282441203495066 0.3074077389439386 1.7270557704896595e-07 6.762693637866915 -0.912316992379512 GMDK(ub)LIVDGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GMDKLIVDGR 10 1 Q99832;F8WBP8;A0A0D9SG95 Q99832 CCT7 T-complex protein 1 subunit eta 1 289739000.0 198299000.0 43911000.0 47529000.0 True False 300834080.598776 36074738.97179109 38134872.317299284 1.0 0.1199157319542667 0.12676380362689016 28.164392774005726 -10.061575000481112 4.935869471293823 1.0000202326058756 0.12333976778471283 0.9999542367109033 0.00279571358026614 31263677.525199473 53266786.08224049 9606.044237878312 0.0010231140190454194 8.678106977914492e-11 10.061575000481112 -0.8766804648211628 GMDK(ub)LIVDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GMDKLIVDGR 10 1 Q99832;F8WBP8;A0A0D9SG95 Q99832 CCT7 T-complex protein 1 subunit eta 1 260295400.0 56664600.0 146568500.0 57062300.0 True False 77615033.92323679 140092619.03278542 43585359.97495792 1.0 1.8049675681561967 0.5615582158743232 26.209832791698208 -6.731959462139215 1.7162167856497268 1.4833732158256112 0.5620490090298086 0.5682520841055243 0.3383403028845836 0.33258551924127566 1.9200219169026715 0.15617601821434934 0.3866640445598607 1.853704643604848e-07 6.731959462139215 -0.9213242067958026 GMDK(ub)LIVDGR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GMDKLIVDGR 10 1 Q99832;F8WBP8;A0A0D9SG95 Q99832 CCT7 T-complex protein 1 subunit eta 1 324884020.0 99218500.0 209885000.0 15780520.0 True False 82504578.87482058 208754307.8460895 19080153.771119416 1.0 2.5302148158688302 0.23126175578774397 26.297970853105554 -6.72726421373148 1.733034229032389 1.9236629739228028 0.2332561992016861 0.5466049725736752 0.6434166431147188 0.3413951459571318 2.007428532752729 0.29435739319389526 0.732748861152863 1.873854155950366e-07 6.72726421373148 -1.6904067747211167 GMDK(ub)LIVDGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GMDKLIVDGR 10 1 Q99832;F8WBP8;A0A0D9SG95 Q99832 CCT7 T-complex protein 1 subunit eta 1 261029500.0 198299000.0 56211000.0 6519500.0 True False 256701964.55766976 53082808.43655976 5333017.895719029 1.0 0.20678769844254294 0.02077513471666841 27.935519096098176 -9.936457701858577 0.375585738207745 1.398333540314944 8.250769769901053e-19 0.9985618387371528 0.01610264858806496 1.370704300303481 0.17837376273674405 0.6657374153466576 0.05102366188010923 1.1575567669244684e-10 9.936457701858577 -1.398333540314944 GMGGAMDLVSSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GMGGAMDLVSSAK 13 0 P55809;E9PDW2;P55809-2 P55809 OXCT1 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 0 6125300.0 1242300.0 2403900.0 2479100.0 False True 1628667.3304503127 2045247.4903288104 2222586.5132063925 1.0 1.2557797728792883 1.3646657433669196 20.63526052019663 -13.182715078520818 0.12479346955276725 1.8790110717662694e-19 1.5345969184356678 0.9996894857462819 0.0026933786758893625 8.992214727443931 0.10174411335146544 2.3409634668307455 0.14337549031916463 6.565758755457794e-14 13.182715078520818 1.5345969184356678 GMGGAMDLVSSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GMGGAMDLVSSAK 13 0 P55809;E9PDW2;P55809-2 P55809 OXCT1 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 0 5976500.0 1242300.0 2338700.0 2395500.0 False True 1701611.8818951694 2235368.5009533116 1829732.2368711384 1.0 1.3136770639281568 1.075293523945822 20.698470581719523 -10.035905906809194 4.954337107350563 0.9999967458887487 1.1944852939388684 0.47019373045562307 0.09731967267901723 3.4980154395002835e-06 6.807824837816615e-07 0.09423094461096206 0.031409789294419836 9.206490157332644e-11 10.035905906809194 0.19448854805011973 GMGGHGYGGAGDASSGFHGGHFVHMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GMGGHGYGGAGDASSGFHGGHFVHMR 26 0 P31942-2;P31942;P31942-3;P31942-4;P31942-6;P31942-5 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 63443400.0 26085400.0 14041000.0 23317000.0 False True 34198212.01137291 11946137.531389324 20904380.512457535 1.0 0.3493205296059494 0.6112711537522957 25.027417562721627 -10.345057114801614 5.823870651797069 1.000079699123287 0.4802958416791984 0.8399544845795792 0.10694089449369246 0.00011068204463727322 1.2447226817958581e-05 0.10356083578106026 0.03451502528354893 4.517965239430122e-11 10.345057114801614 -0.5197838574440885 GMGGHGYGGAGDASSGFHGGHFVHMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GMGGHGYGGAGDASSGFHGGHFVHMR 26 0 P31942-2;P31942;P31942-3;P31942-4;P31942-6;P31942-5 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 56014700.0 13388000.0 5293700.0 37333000.0 False True 12963005.2682207 7407502.016280809 27554367.33400698 1.0 0.5714340049248133 2.1256156858593243 23.62789688729052 -6.833177541640967 1.3136970187184542 0.7714629385121601 2.1702047729647655 0.9120751098505954 0.19434554249979263 0.17692144611593832 0.5960219882804196 0.11611632821719199 0.2672151098911248 1.4683258963526324e-07 6.833177541640967 1.3987418344526055 up GMGGHGYGGAGDASSGFHGGHFVHMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GMGGHGYGGAGDASSGFHGGHFVHMR 26 0 P31942-2;P31942;P31942-3;P31942-4;P31942-6;P31942-5 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 56321180.0 26085400.0 17688000.0 12547780.0 False True 35729877.31142898 16906485.67360593 9584252.79364095 1.0 0.47317502733764 0.26824197324000376 25.09062762424452 -13.618411936052631 0.135960501738938 3.268923766389989 6.665966822258618e-17 0.9996296989095776 0.005931193862849915 10.439079551010323 0.11170815871359897 6.41867460568261 0.23444800809890243 2.4076206741937633e-14 13.618411936052631 -3.268923766389989 GMGGHGYGGAGDASSGFHGGHFVHMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GMGGHGYGGAGDASSGFHGGHFVHMR 26 0 P31942-2;P31942;P31942-3;P31942-4;P31942-6;P31942-5 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 29814400.0 13388000.0 10304000.0 6122400.0 False True 11132715.188962737 10248490.306816127 7402565.533220802 1.0 0.9205741935243925 0.6649380144531046 23.408302162724798 -6.94985979081729 0.5603790582287772 1.0033367641601567 0.569950192710507 0.9991902452803851 0.004067946721068235 0.08354206085845799 0.036195492574936955 0.004358613242233109 0.02125205639923184 1.1223807492290024e-07 6.94985979081729 -0.43338657144964976 GMGLSLMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 GMGLSLMR 8 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 30633800.0 9274300.0 10717500.0 10642000.0 False True 12158697.112448966 9118490.7764878 9540867.925272265 1.0 0.7499562405540656 0.7846949255363574 23.535485306634907 -10.515403903317504 9.322329963933925 1.0000070661673994 0.7673255830907741 0.983556653959711 0.014182008756983307 2.082867335036228e-06 1.0828206048518382e-07 0.013732087637694734 0.0045772236442970056 3.052081290864549e-11 10.515403903317504 -0.23268148307662528 GMGLSLMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GMGLSLMR 8 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 6099770.0 2518600.0 952770.0 2628400.0 False True 2438648.4216119368 1333216.0296299108 1939943.1896901939 1.0 0.5467028448277347 0.7954993317191247 21.217650350025714 -10.100244725716612 5.264045506566406 1.0000060354509932 0.6711010882730922 0.6997089888615429 0.10157074044800576 7.19463422340316e-06 1.229975267974411e-06 0.09834725001902053 0.03278181551791996 7.938807554341255e-11 10.100244725716612 -0.328904947177901 GMGLSLMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GMGLSLMR 8 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 21144600.0 9274300.0 6634500.0 5235800.0 False True 12703259.338533675 6341365.852642381 3999211.874685822 1.0 0.4991920328200084 0.31481777771431746 23.5986953681578 -13.999999999999998 0.13887649779727898 3.390005354746111 0.08352677935184258 0.99960745075066 0.005735761448161176 11.933048846531655 0.11667509041813108 7.733811396812998 0.20661953254006865 1.0000000000000041e-14 13.999999999999998 -3.3064785753942685 GMGLSLMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GMGLSLMR 8 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 8298600.0 2518600.0 4015700.0 1764300.0 False True 2094327.4928982304 3994066.6270459546 2133206.9727984867 1.0 1.9070879032002652 1.0185641835062065 20.99805562545999 -6.641372923424693 2.0392318918044174 1.5925723794626816 1.0222543839407927 0.1598857966185102 0.3879850028609743 0.529998911580736 4.213870855530913 0.15483685897500757 0.42969969158208626 2.2836370296925967e-07 6.641372923424693 -0.5703179955218889 GMGSLDAMDK(ub)HLSSQNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GMGSLDAMDKHLSSQNR 17 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 28396800.0 5182800.0 10947000.0 12267000.0 True False 6794700.990306594 9313750.271071792 10997728.513372941 1.0 1.3707373266842653 1.6185743168187148 22.695978634033775 -8.201855430281842 0.08132217567430025 1.2807220206685632e-06 2.6890505337910495 0.9999937792725307 0.0006339536392264244 0.08607148751180309 0.016025014592558694 0.25265960129607573 0.2598799841614683 6.282674642429798e-09 8.201855430281842 2.6890492530690286 GMGSLDAMDK(ub)HLSSQNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GMGSLDAMDKHLSSQNR 17 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 39639700.0 12262000.0 7105700.0 20272000.0 True False 11872749.52187946 9943043.065735977 14962155.053035924 1.0 0.8374676015368334 1.2602097791638924 23.50115074091276 -6.802523434607178 1.4460019761891756 0.9106084991161046 1.2663871535117521 0.8393172092653286 0.06979349506624366 0.2171838438935805 0.8963167810921079 0.0379698257906977 0.08815514996652699 1.5757109948054706e-07 6.802523434607178 0.3557786543956475 GMGSLDAMDK(ub)HLSSQNR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GMGSLDAMDKHLSSQNR 17 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 77306100.0 16364500.0 26530900.0 34410700.0 True False 24826142.905202083 21796253.60813219 27609410.062254436 1.0 0.8779556974017495 1.1121103333562599 24.56535679991938 -6.765090622988057 1.593465506752522 0.9295586792759222 1.113182765855693 0.7113216921569874 0.051376492157543946 0.2744580335497608 1.3745467360879868 0.025426972625814486 0.06079803805852818 1.7175499535232425e-07 6.765090622988057 0.1836240865797708 GMGSLDAMDK(ub)HLSSQNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GMGSLDAMDKHLSSQNR 17 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 26745800.0 5182800.0 8418000.0 13145000.0 True False 7099021.219903635 8046064.925396587 10040421.72977294 1.0 1.1334048280962608 1.4143388811999118 22.759188695556666 -6.959023476960181 0.44898495702173713 0.9908458839421072 1.568016055973112 0.9997322469345834 0.0028257536485627433 0.08005182794009305 0.022434304533331343 0.0037493444712644913 0.023241429465980283 1.0989464313119055e-07 6.959023476960181 0.5771701720310048 GMGSLDAMDK(ub)HLSSQNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GMGSLDAMDKHLSSQNR 17 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 30736600.0 12262000.0 11061000.0 7413600.0 True False 10196396.29870489 11001412.197563414 8963749.48338654 1.0 1.0789510210544457 0.8791095619268039 23.281556016347036 -6.799514081066081 1.4578091887266762 1.0435876700416715 0.876381121519041 0.8307642827623959 0.03380809616076335 0.22145065513653647 0.9291736615378503 0.01824439940536613 0.04244400219447718 1.5866674738315518e-07 6.799514081066081 -0.1672065485226305 GMGSLDAMDK(ub)HLSSQNR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GMGSLDAMDKHLSSQNR 17 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 57162300.0 16364500.0 23115600.0 17682200.0 True False 21184167.842520565 21829196.539754536 14464221.034693293 1.0 1.03044862097152 0.6827844804770151 24.336483122011828 -6.885560317930505 1.0482552756613004 1.0207164400411117 0.6553554366892669 0.9779024656219185 0.02336902771616606 0.12282071690230037 0.24346488064062033 0.017077142934200217 0.04194829219866044 1.3014865432463882e-07 6.885560317930505 -0.36536100335184485 GMIFVCSATHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GMIFVCSATHK 11 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 25726200.0 9039500.0 5340700.0 11346000.0 False True 11850872.03864253 4543888.377885552 10172024.758517105 1.0 0.383422280070964 0.8583355490928304 23.49848988700901 -9.945974370873422 6.725163986009782 1.000000030923081 0.6208789145819364 0.45937201208783096 0.19388253019679427 8.971970615280606e-08 1.4142315795171965e-08 0.18772596662980973 0.06257531754772652 1.1324671918272758e-10 9.945974370873422 -0.37912111634114454 GMIFVCSATHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GMIFVCSATHK 11 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 26155600.0 9039500.0 6506100.0 10610000.0 False True 12381647.43330226 6218638.989204407 8104136.519809114 1.0 0.5022464920522987 0.6545281283015577 23.561699948531903 -10.857991311982474 10.958429582189616 1.0117144382174819 0.5783873101769361 0.9108772004550729 0.06216871766779984 0.016818206105941723 0.00021794420696940141 0.05689752192103085 0.02006486734853831 1.386783571060564e-11 10.857991311982474 -0.43332712804054574 GMISSSK(ub)TDDLTCQQEETFLLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GMISSSKTDDLTCQQEETFLLAK 23 1 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 64378300.0 6009300.0 10055000.0 48314000.0 True False 9116547.438677067 8260606.68992643 38764716.72322157 1.0 0.9061113042510701 4.252126913612249 23.120056128783812 -6.900446972821975 0.9584696435363365 0.8625859774128275 4.606513534441108 0.9867864704357948 0.17882437839267462 0.11107596086445519 0.17558379385886455 0.13981664460388177 0.3645887762251631 1.2576304011493742e-07 6.900446972821975 3.7439275570282806 up GMISSSK(ub)TDDLTCQQEETFLLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GMISSSKTDDLTCQQEETFLLAK 23 1 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 43635700.0 6009300.0 9138400.0 28488000.0 True False 7779157.311012179 8629840.006700784 23303476.3115643 1.0 1.1093540934677306 2.9956299094987946 22.89118245087626 -6.91881022574451 0.8335012740651411 0.9565688835777209 3.29163961415797 0.9938440225450349 0.07187429280999114 0.09887699503673256 0.10927843132844224 0.06154000177529355 0.18229670491714062 1.2055626216435788e-07 6.91881022574451 2.3350707305802487 up GMLSTHLTSMFEYLAPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GMLSTHLTSMFEYLAPPR 18 0 P50750;P50750-2 P50750 CDK9 Cyclin-dependent kinase 9 0 15297800.0 5380400.0 2792300.0 7125100.0 False True 5209602.14708206 3907279.95165213 5258822.56158179 1.0 0.7500150378739823 1.009448017931139 22.312741768632495 -11.06344791808547 10.82445381085869 1.5847104456080547 0.8797315279025626 0.22272407752850865 0.10591307059827966 0.04259282117034728 0.0002496596614005557 0.0029226342084435523 0.034183296547735637 8.64076277125221e-12 11.06344791808547 -0.7049789177054921 GMLSTHLTSMFEYLAPPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GMLSTHLTSMFEYLAPPR 18 0 P50750;P50750-2 P50750 CDK9 Cyclin-dependent kinase 9 0 14083700.0 5380400.0 3642900.0 5060400.0 False True 4474040.992134379 3623274.974640964 6118506.243353996 1.0 0.809843937731212 1.3675570371640942 22.09314704406677 -6.814695762326079 1.3947056400975648 0.8969250774505768 1.3783972882747244 0.8717289169093432 0.08290913588362063 0.20047059871291442 0.7676260820116981 0.04673034941287719 0.10788553382124814 1.5321604149537753e-07 6.814695762326079 0.4814722108241476 GMNFSVVVFDTAPTGHTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GMNFSVVVFDTAPTGHTLR 19 0 O43681 O43681 ASNA1 ATPase ASNA1 0 12359000.0 5999200.0 2718300.0 3641500.0 False True 5808758.679796049 3803731.3657472343 2687681.9073416633 1.0 0.6548268873653376 0.4626947090589121 22.469798464823352 -10.76900747925662 0.1052987651060741 1.9451013693193844 2.702710527630571e-15 0.9998847310932782 0.0023866821254882407 2.860748129999422 0.06020528614827911 0.9576591061670037 0.28900005008935836 1.702129194712183e-11 10.76900747925662 -1.9451013693193817 GMNFSVVVFDTAPTGHTLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GMNFSVVVFDTAPTGHTLR 19 0 O43681 O43681 ASNA1 ATPase ASNA1 0 114239000.0 29709000.0 38415000.0 46115000.0 False True 45070725.01883039 31559543.112235043 37000350.03707752 1.0 0.7002226633596327 0.82093975682927 25.425687322000734 -10.052556832740107 4.82771010603533 1.0000063852407988 0.7605812102851645 0.8398632762074992 0.049282547050794635 68287539.74904191 0.40998573268809513 4847.004714650413 0.01687072669257567 8.860192696239323e-11 10.052556832740107 -0.2394251749556343 GMNFSVVVFDTAPTGHTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GMNFSVVVFDTAPTGHTLR 19 0 O43681 O43681 ASNA1 ATPase ASNA1 0 11093200.0 5999200.0 1910300.0 3183700.0 False True 4988600.609622435 1900008.834735137 3849396.9502343936 1.0 0.38087010434754776 0.7716386320463 22.25020374025763 -10.10493821503853 5.403757510195172 1.00000617174845 0.5762543681968029 0.6105721847166774 0.15953058340082654 1.186188740874177e-05 1.964942996004774e-06 0.1544670721818983 0.051488274393407245 7.853473542074067e-11 10.10493821503853 -0.4237518035516472 GMNFSVVVFDTAPTGHTLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GMNFSVVVFDTAPTGHTLR 19 0 O43681 O43681 ASNA1 ATPase ASNA1 0 87185000.0 29709000.0 31151000.0 26325000.0 False True 38458886.15194136 29417419.466070265 21534120.1173101 1.0 0.7649056540496119 0.5599257355565167 25.196813644093183 -6.972731641987745 0.18144045396234643 1.1554672262313748 0.16381317241930055 0.9999965942382497 0.00033176487852164054 0.07542587058777803 0.005731334946318574 0.00779379899675126 0.02290338361024836 1.0648007736527388e-07 6.972731641987745 -0.9916540538120742 GMQLMHANAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GMQLMHANAQR 11 0 P13284 P13284 IFI30 Gamma-interferon-inducible lysosomal thiol reductase 0 7870400.0 1380300.0 5112100.0 1378000.0 False True 1809586.6668442164 4349394.606809728 1235417.7787093767 1.0 2.4035293177721884 0.6827071625499168 20.78722877393 -6.6898320113408145 1.8668410568447147 1.8800489465509995 0.6886354592740419 0.3697324360286449 0.5936122173678066 0.4170201789901986 2.8176277776139975 0.25437994254341467 0.6626052931393869 2.042527858375604e-07 6.6898320113408145 -1.1914134872769577 GMQLMHANAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GMQLMHANAQR 11 0 P13284 P13284 IFI30 Gamma-interferon-inducible lysosomal thiol reductase 0 6515700.0 1335300.0 0.0 5180400.0 False True 1292911.6324062662 0.0 3823497.8313312572 1.0 0.0 2.957276998285847 20.302192242890055 -6.8154866598576564 1.3913557912046615 0.4584338058669971 3.0157608520596355 0.8736713332187628 0.4365382890462331 0.19941220181438538 0.759731497270344 0.24663061633244715 0.5692219299345859 1.5293727231530767e-07 6.8154866598576564 2.5573270461926385 GMSEALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GMSEALK 7 0 E9PNP3;E9PR47;Q9H7C9;E9PJP1;E9PLK9;K4DI89;Q9H7C9-3;Q9H7C9-2 E9PNP3 AAMDC Mth938 domain-containing protein 0 11793900.0 4948000.0 4027700.0 2818200.0 False True 6405283.539661568 3803554.954367147 2305316.5171739166 1.0 0.5938152356278225 0.3599085821727294 22.6108310044047 -9.223433150905947 0.15619814045217625 1.5273283563475202 6.7729548555841906e-21 0.9997934244553137 0.0038008994682526527 0.6632591282771826 0.05550234923807028 0.33482998415655296 0.17310041106412788 5.978150567244924e-10 9.223433150905947 -1.5273283563475202 GMSEALVDKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GMSEALVDKR 10 1 Q9P260 Q9P260 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 0 35134870.0 6120000.0 18588900.0 10425970.0 False True 8023379.266164309 15815508.578964693 9347190.637366181 1.0 1.9711779855229905 1.1649942408661356 22.935778564572974 -10.137572356489002 4.270325777659588 0.9999127432282684 1.5680861122727836 0.39833791654496 0.3291231362043715 76650133.13219109 20.807262925206352 88865.62944469776 0.11266760358353856 7.284967917566173e-11 10.137572356489002 0.5681733690445152 GMSEALVDKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GMSEALVDKR 10 1 Q9P260 Q9P260 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 0 15786700.0 4522800.0 3273400.0 7990500.0 False True 4379226.1896555545 4580485.690555489 5897548.340138288 1.0 1.0459577770555315 1.3467101457488673 22.062244537102142 -6.934026131982612 0.712963331418265 0.9960383014493841 1.4153014004626814 0.9972721831949837 0.008030516927483916 0.09060026792516941 0.06782774363946407 0.007500094775442783 0.02663614566671164 1.1640559847582702e-07 6.934026131982612 0.4192630990132973 GMSEALVDKR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GMSEALVDKR 10 1 Q9P260 Q9P260 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 0 127183400.0 46190000.0 50552600.0 30440800.0 False True 70073606.94132327 41531093.56073345 24424162.53732339 1.0 0.5926781191028153 0.348550097582035 26.062367823072282 -8.870039427995065 0.16922594085947426 1.4355500364370426 1.076818496311655e-10 0.999784568141059 0.003944167685884853 0.3714873494602211 0.05164848517534271 0.23736176923097316 0.15289867939165325 1.3488404207832584e-09 8.870039427995065 -1.4355500363293607 GMSEALVDKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GMSEALVDKR 10 1 Q9P260 Q9P260 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 0 30206700.0 6120000.0 12966300.0 11120400.0 False True 8382729.386781328 12393405.992179804 8493990.551827082 1.0 1.4784451961103366 1.013272665728802 22.998988626095866 -10.501147870783726 3.429586707730436 0.9952163803236805 1.2458589310023498 0.2713826580314813 0.1899058905699956 22423004.94415041 22917652.372043554 721241.1508266488 0.06500980126163074 3.153930574288105e-11 10.501147870783726 0.25064255067866925 GMSEALVDKR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GMSEALVDKR 10 1 Q9P260 Q9P260 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 0 106791100.0 46190000.0 37194000.0 23407100.0 False True 59793865.5410202 35124121.20384628 19147247.977127828 1.0 0.5874201456293237 0.3202209424642784 25.83349414516473 -8.401346884101619 0.19859738731679785 1.3041575892829222 3.816357387083531e-24 0.9997425889501272 0.004486328145950116 0.11984796713231685 0.04732821734462276 0.13433527655759947 0.12305654869840352 3.9687442726342715e-09 8.401346884101619 -1.3041575892829222 down GMSLLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GMSLLVR 7 0 Q5MIZ7-3;Q5MIZ7-2;Q5MIZ7;G3V4R3;G3V231;G3V5A2;H0YIY8;G3V5Z3;Q6IN85-5;Q6IN85-4;Q6IN85-2;Q6IN85;Q5MIZ7-4 Q5MIZ7-3 SMEK2;SMEK1 Serine/threonine-protein phosphatase 4 regulatory subunit 3B;Serine/threonine-protein phosphatase 4 regulatory subunit 3A 0 3855670.0 1230100.0 1760100.0 865470.0 False True 1684901.2122025674 1682332.9621276457 661063.8109141567 1.0 0.998475726614521 0.39234573880446605 20.68423257625448 -6.907449459029337 0.9129242471705067 1.020314185438297 0.3181401106548817 0.9899230411814101 0.028719111875294738 0.10612902518498221 0.148093276760785 0.023220140358694952 0.06302035278179033 1.237515197245323e-07 6.907449459029337 -0.7021740747834154 down GMSLNLEPDNVGVVVFGNDK ddPTM_RPMI8226_Bortezomib_1h_R1 2 GMSLNLEPDNVGVVVFGNDK 20 0 P25705;P25705-2;P25705-3;K7EK77;K7ERX7;K7EJP1;K7EQH4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 24083290.0 8280110.0 11742860.0 4060320.0 False True 10855304.394699303 9990871.06130977 3640197.035739656 1.0 0.9203676560362839 0.3353380894152707 23.371896845490802 -6.931717762379068 0.7325605329327656 1.0083540988893722 0.20980861605371068 0.9968650893207781 0.016592364343788843 0.09175586143046961 0.07338379286682423 0.015273862052658778 0.052444116232864345 1.1702596677843544e-07 6.931717762379068 -0.7985454828356615 down GMSLNLEPDNVGVVVFGNDK ddPTM_RPMI8226_Bortezomib_2h_R1 2 GMSLNLEPDNVGVVVFGNDK 20 0 P25705;P25705-2;P25705-3;K7EK77;K7ERX7;K7EJP1;K7EQH4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 108341500.0 57888900.0 15553300.0 34899300.0 False True 56051248.55628179 21763813.799388003 25758126.373442 1.0 0.38828419276931314 0.45954598758987375 25.740243174011084 -10.419409429328212 5.982378942852632 1.0001937196585668 0.4239150901812429 0.988653913646252 0.02909250591088123 7.519231567797747e-05 7.297465413375225e-06 0.028177967446626775 0.009389565907690198 3.807067444501081e-11 10.419409429328212 -0.5762786294773239 GMSLNLEPDNVGVVVFGNDK ddPTM_RPMI8226_Bortezomib_8h_R1 2 GMSLNLEPDNVGVVVFGNDK 20 0 P25705;P25705-2;P25705-3;K7EK77;K7ERX7;K7EJP1;K7EQH4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 465831000.0 99950000.0 200397000.0 165484000.0 False True 151631457.3237769 164634589.64109248 132776014.86578602 1.0 1.0857548463017812 0.8756495334755698 27.175993843855235 -6.795878062561816 1.4725762348520355 1.047564751684465 0.8730324545526982 0.819867225296142 0.0366088968303481 0.22669481930867896 0.9708602491689378 0.01956129700174269 0.045613461557622914 1.600007201700191e-07 6.795878062561816 -0.17453229713176688 GMSLNLEPDNVGVVVFGNDK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GMSLNLEPDNVGVVVFGNDK 20 0 P25705;P25705-2;P25705-3;K7EK77;K7ERX7;K7EJP1;K7EQH4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 25132910.0 8280110.0 5453900.0 11398900.0 False True 11341490.428559138 5212928.664364503 8706714.587714624 1.0 0.45963347561778717 0.7676869845774542 23.435106907013694 -10.203115655504675 5.661464023387518 1.0000118969974812 0.6136602300976125 0.6771203785687949 0.12576231840423147 1.8885643457626774e-05 2.6582273261865256e-06 0.12177258793860482 0.04058961372999419 6.264470154563517e-11 10.203115655504675 -0.38635166689986866 GMSLNLEPDNVGVVVFGNDK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GMSLNLEPDNVGVVVFGNDK 20 0 P25705;P25705-2;P25705-3;K7EK77;K7ERX7;K7EJP1;K7EQH4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 108490900.0 57888900.0 23781500.0 26820500.0 False True 48137185.26309713 23653384.339241862 32428542.546019267 1.0 0.4913744792090075 0.6736692718691135 25.52064844944536 -10.054068614920324 4.9459086974376 1.0000087527285348 0.582521875535648 0.8748890490147359 0.07442153747576484 7.1828308090585e-06 1.3737529723832201e-06 0.07205985331726175 0.024019447935211914 8.829403921511754e-11 10.054068614920324 -0.4174868771928868 GMSLNLEPDNVGVVVFGNDK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GMSLNLEPDNVGVVVFGNDK 20 0 P25705;P25705-2;P25705-3;K7EK77;K7ERX7;K7EJP1;K7EQH4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 276475000.0 99950000.0 97724000.0 78801000.0 False True 129387245.30904882 92285573.49369997 64460026.566539526 1.0 0.7132509334538394 0.4981945972539494 26.947120165947684 -7.4230905796804585 0.14518629398011762 1.302366274697115 1.7418410099898757e-09 0.9999906344837913 0.0006290421136831535 0.12438723900852433 0.011140178186514896 0.033861205959144575 0.05986929987992981 3.77493449878648e-08 7.4230905796804585 -1.3023662729552739 down GMTELEPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GMTELEPSK 9 0 E7ENT5;E7EV45;Q9ULF5 E7ENT5 SLC39A10 Zinc transporter ZIP10 0 27380300.0 7761900.0 11565000.0 8053400.0 False True 10175926.066346513 9839547.080016932 7220111.421667689 1.0 0.9669436487513364 0.7095286831481415 23.27865675801811 -6.9306011888495505 0.7418396866463107 1.0038284954521381 0.6558642894446232 0.9966550915101408 0.0075093908708292936 0.09232691773240755 0.07615944291788652 0.006866035674755117 0.023215104630717572 1.1732722829676367e-07 6.9306011888495505 -0.347964206007515 GMTELEPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GMTELEPSK 9 0 E7ENT5;E7EV45;Q9ULF5 E7ENT5 SLC39A10 Zinc transporter ZIP10 0 7720900.0 3244300.0 4476600.0 0.0 False True 3141311.4723400334 6264129.725160594 0.0 1.0 1.9941128984876828 0.0 21.58293556781287 -6.7772938376161225 1.5866858335772278 1.569026223795701 1.0558014891915589e-10 0.7347161240889899 0.41930512954985527 0.2602116749542753 1.3001861696680153 0.20955024813809714 0.4875061071933394 1.669960360005053e-07 6.7772938376161225 -1.5690262236901207 GMTELEPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GMTELEPSK 9 0 E7ENT5;E7EV45;Q9ULF5 E7ENT5 SLC39A10 Zinc transporter ZIP10 0 70011000.0 26592000.0 30172000.0 13247000.0 False True 40342008.13560661 24787570.86508804 10628724.643633645 1.0 0.6144357212404126 0.26346543305196884 25.26577956410623 -7.622194490263762 0.29702850061985536 1.098361812727588 3.0092149207133847e-13 0.9996024912230331 0.005997224259950781 0.12663370289558126 0.03729557534636219 0.030037393595653845 0.07331333379687738 2.3867421878785218e-08 7.622194490263762 -1.0983618127272872 down GMTELEPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GMTELEPSK 9 0 E7ENT5;E7EV45;Q9ULF5 E7ENT5 SLC39A10 Zinc transporter ZIP10 0 22778500.0 9488900.0 0.0 13289600.0 False True 12997202.757880613 0.0 10150870.187903425 1.0 0.0 0.7810042189076901 23.63169782580622 -10.895254815787684 9.316886144422199 1.0644277909711803 0.3905021094543071 0.44813521500373965 0.3188436372141291 0.1621801147512415 0.0018233088604628436 0.11733761802879111 0.10290634141454345 1.2727560913068381e-11 10.895254815787684 -0.6739256815168733 GMTELEPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GMTELEPSK 9 0 E7ENT5;E7EV45;Q9ULF5 E7ENT5 SLC39A10 Zinc transporter ZIP10 0 14899800.0 3244300.0 10422000.0 1233500.0 False True 2697779.196859259 10365854.617394963 1491419.146940393 1.0 3.8423658353740877 0.5528321771762106 21.363340843247148 -6.678213544615597 1.9090983828112038 2.8013594785993985 0.5657780828303873 0.31563224863435 1.205148562512104 0.44247716780777524 3.116624830421033 0.5069267543974896 1.3396295322031515 2.0979080788180928e-07 6.678213544615597 -2.235581395769011 GMTELEPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GMTELEPSK 9 0 E7ENT5;E7EV45;Q9ULF5 E7ENT5 SLC39A10 Zinc transporter ZIP10 0 104947300.0 39205700.0 37927400.0 27814200.0 False True 50752551.50988475 35816706.849135935 22752300.997792497 1.0 0.7057124377709393 0.44829866323787043 25.596977017703956 -7.089669515814881 0.1923408945205823 1.1769225978140085 1.857923333138827e-12 0.9999948358156046 0.0005121825661872497 0.07545801810731194 0.006777250827807107 0.010320882163080393 0.029217459639883973 8.134492895457849e-08 7.089669515814881 -1.1769225978121507 down GMTLVTPLQLLLFASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GMTLVTPLQLLLFASK 16 0 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 0 2195820000.0 1009800000.0 644820000.0 541200000.0 False True 1307206006.133844 608935200.1576654 442707153.1809395 1.0 0.465829561140585 0.3386667067804239 30.283839371254164 -13.999999999999973 0.20161476807757606 3.9877917437636805 0.25738297620311823 0.9994870701870515 0.006489206767971845 12.563274563163299 0.14236825759496738 14.812422640042312 0.08000638410895164 1.0000000000000614e-14 13.999999999999973 -3.7304087675605624 GMTSLQCDCTEK(ub)LQNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GMTSLQCDCTEKLQNK 16 1 Q9BTE7;H0YCN4 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 1 7885100.0 2157900.0 2692800.0 3034400.0 True False 2829027.797133327 2291044.73645219 2720429.3960201214 1.0 0.8098346501839683 0.9616128193497253 21.431874921593646 -9.95464825306189 5.2460114759913345 1.000000374997871 0.8857237347946509 0.430473333480044 0.06196317809425415 2.717598459666775e-07 5.4192622142140565e-08 0.059995785888354594 0.019998529736053042 1.1100735300748529e-10 9.95464825306189 -0.11427664020322004 GMTSLQCDCTEK(ub)LQNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GMTSLQCDCTEKLQNK 16 1 Q9BTE7;H0YCN4 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 1 43888700.0 4467900.0 9046800.0 30374000.0 True False 6778130.947242659 7432327.857028977 24370565.586602867 1.0 1.0965158263949513 3.595469868654102 22.692456077953803 -6.915054103599698 0.8606195799270258 0.934436844981125 3.9559087646788194 0.9926928045057096 0.10269939489848903 0.10116999756129787 0.1213449722601514 0.08624170626056174 0.24728495242467965 1.2160344998909453e-07 6.915054103599698 3.0214719196976945 up GMTSLQCDCTEK(ub)LQNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GMTSLQCDCTEKLQNK 16 1 Q9BTE7;H0YCN4 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 1 8609400.0 2157900.0 2665100.0 3786400.0 True False 2955733.945054808 2547347.0696928483 2892130.303355822 1.0 0.8618323289735784 0.9784812696672511 21.495084983116538 -10.294454999463932 4.7118441172063985 1.0000378284123073 0.9201567993250084 0.3844916742018577 0.04762173062311621 1.8933171114384255e-05 2.83503778532082e-06 0.04613138082549073 0.015369847468337357 5.0762733541157495e-11 10.294454999463932 -0.07988102908729888 GMTSLQCDCTEK(ub)LQNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GMTSLQCDCTEKLQNK 16 1 Q9BTE7;H0YCN4 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 1 50432000.0 4467900.0 5639100.0 40325000.0 True False 5783784.625475738 5325279.127832708 32986263.769440863 1.0 0.9207256965234392 5.7032316909151195 22.463582400046253 -6.903131125678888 0.9412486397496904 0.8178801532087696 6.238441441547288 0.9880610522624073 0.24432245151052723 0.10913747539930649 0.16470137566331974 0.19347159353922877 0.5117747592489443 1.2498815989487485e-07 6.903131125678888 5.420561288338519 up GMTVEGLK(ub)QFIAAQGSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GMTVEGLKQFIAAQGSSR 18 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 7660660.0 972960.0 3158900.0 3528800.0 True False 1275559.9821580432 2687604.4332957594 3163673.6266397974 1.0 2.10699964791053 2.480223330060393 20.28269931140629 -10.135695991728161 0.2562302602311078 4.537614697673232e-13 2.6729486394115347 0.9990863726352929 0.018999066278188453 1.6247717852613628 0.1188835373949502 1.2942142831408106 0.162677710766087 7.31651063608715e-11 10.135695991728161 2.672948639411081 GMTVEGLK(ub)QFIAAQGSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GMTVEGLKQFIAAQGSSR 18 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 16577400.0 3385300.0 6257600.0 6934500.0 True False 3277835.50451953 8756292.312952902 5118146.419459225 1.0 2.6713641672620825 1.561440899765179 21.644312025113408 -10.506639684800797 5.135134356408122 0.9967314938388757 2.1164025335136483 0.5742770804292389 0.45312427650173726 0.016979927800280018 0.0016313533287850754 0.4393581123426671 0.1462452313877839 3.1142990637398964e-11 10.506639684800797 1.1196710396747727 GMTVEGLK(ub)QFIAAQGSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GMTVEGLKQFIAAQGSSR 18 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 7505860.0 972960.0 2822000.0 3710900.0 True False 1332689.6052553528 2697314.7088939357 2834461.8483845107 1.0 2.023963193122611 2.1268732323018367 20.34590937292918 -10.874874920409972 0.42547510221160695 8.221141313011404e-22 2.131325259218785 0.999554318317785 0.010739144864604526 2.561055601941224 0.2062745658226732 2.5899850438210774 0.024564092510230343 1.3339055501811398e-11 10.874874920409972 2.131325259218785 GMTVEGLK(ub)QFIAAQGSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GMTVEGLKQFIAAQGSSR 18 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 12353500.0 3385300.0 5571200.0 3397000.0 True False 2815026.944218367 5541186.839803384 4107296.994046626 1.0 1.9684311907508134 1.4590613430831927 21.424717300547684 -10.212714651854498 4.848176629025942 0.9998911958590136 1.7137462669185852 0.7235997467050566 0.20794936952960086 0.0002445954714238112 3.971958619843181e-05 0.20137650124768092 0.06711537041942958 6.127528616425228e-11 10.212714651854498 0.7138550710595716 GMVFSINLGFSDLTNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GMVFSINLGFSDLTNK 16 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 73511000.0 17490000.0 25544000.0 30477000.0 False True 26533608.69027374 20985473.623817086 24453207.591456335 1.0 0.7909016021446642 0.9215937370938916 24.6613175661449 -10.385625640010023 5.339403249893329 1.0000753736206442 0.8562476696605987 0.6173172975481181 0.053354840670105305 4.789806264948869e-05 5.5113416526126276e-06 0.05168764543303881 0.01722020077957078 4.115042832030184e-11 10.385625640010023 -0.14382770396004552 GMVFSINLGFSDLTNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GMVFSINLGFSDLTNK 16 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 26062700.0 11531000.0 7286600.0 7245100.0 False True 14927106.809991432 6881094.30456381 5926566.1410037475 1.0 0.4609797727150959 0.3970338134806412 23.83143123187049 -13.999999999999998 0.30076620294217826 5.9384878749767465 0.3814244062962625 0.999651539716787 0.005048171263654334 16.638461358238263 0.17419219047318307 51.157278081995635 0.0230337081712809 1.0000000000000041e-14 13.999999999999998 -5.557063468680484 GMVPFVFVGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GMVPFVFVGTK 11 0 A8MQB8;Q06787-2;A0A087WXI3;G3V0J0;Q06787-11;Q06787-8;Q06787-9 A8MQB8 FMR1 Fragile X mental retardation protein 1 0 4023900.0 1241000.0 1088700.0 1694200.0 False True 1626963.0178610953 926270.2037193626 1518900.435913952 1.0 0.5693246825838081 0.9335801854370305 20.633750027123316 -10.077724159995737 7.286365757254039 1.0000000473554986 0.7514524340104193 0.383017364363442 0.14870668633188291 1.1443329626905029e-07 1.4575740937734626e-08 0.14398465672740707 0.04799487663608938 8.361339159593634e-11 10.077724159995737 -0.24854761334507935 GMVPFVFVGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GMVPFVFVGTK 11 0 A8MQB8;Q06787-2;A0A087WXI3;G3V0J0;Q06787-11;Q06787-8;Q06787-9 A8MQB8 FMR1 Fragile X mental retardation protein 1 0 4043750.0 1241000.0 997050.0 1805700.0 False True 1699831.236763991 952997.0341965614 1379230.8495588424 1.0 0.5606421470467883 0.8113928134327716 20.696960088646208 -10.181615930492027 5.480917236057905 1.0000102662093955 0.68601748023974 0.6764354795360815 0.10236853088489359 1.2842362643003714e-05 1.91771165719982e-06 0.0991211426770083 0.033039301274388866 6.582396961014309e-11 10.181615930492027 -0.3139927859696555 GMWSEGNGSHTIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GMWSEGNGSHTIR 13 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 6166040.0 568240.0 3538300.0 2059500.0 False True 744968.1428439874 3010399.4321853737 1846402.6961189818 1.0 4.04097740433958 2.47849886448857 19.5068192072013 -10.084182041540307 16.65966372736325 0.9999999999999525 3.259738134414075 0.7360684270914637 0.6378791927806478 0.0 0.0 0.6176238726329197 0.2058746242109732 8.237927366134851e-11 10.084182041540307 2.2597381344141225 GMWSEGNGSHTIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GMWSEGNGSHTIR 13 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 3707840.0 568240.0 1470500.0 1669100.0 False True 778333.6841085978 1405528.4477067783 1274892.956193535 1.0 1.8058173202621801 1.6379773639806319 19.57002926872419 -10.078872847977166 4.543280305335498 0.9999565468865095 1.7218973421219594 0.961037964103311 0.06852037536262692 10670198.823216747 11835457.339520609 4079.992241643534 0.02345634790849748 8.339253041579425e-11 10.078872847977166 0.72194079523545 GNAAWQEQLK(ub)QK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNAAWQEQLKQK 12 1 P07814;V9GYZ6;V9GZ76 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 5263850.0 817150.0 1673800.0 2772900.0 True False 1071291.563291857 1424075.5644212998 2485986.9075349974 1.0 1.3293071776327732 2.3205511858005066 20.030919747516627 -6.951375447707486 0.543537310759656 0.9857363137459855 2.7101757776386024 0.9993048272389622 0.014797595420899316 0.08293816297119634 0.03371313283363513 0.016197744833317786 0.08213679558950503 1.118470547278725e-07 6.951375447707486 1.724439463892617 up GNAAWQEQLK(ub)QK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNAAWQEQLKQK 12 1 P07814;V9GYZ6;V9GZ76 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 23002800.0 6099400.0 4571400.0 12332000.0 True False 9253235.725869399 3755597.9534887807 9894574.794692382 1.0 0.4058686133964148 1.0693097082818266 23.14152651326388 -6.670646827811736 1.9353608312349844 0.6209751870856358 1.0666199550427733 0.2818269363418424 0.2523371235204996 0.45961353857185366 3.319667919609124 0.10494916219173947 0.2801328783730078 2.1347802299934083e-07 6.670646827811736 0.4456447679571375 GNAAWQEQLK(ub)QK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNAAWQEQLKQK 12 1 P07814;V9GYZ6;V9GZ76 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 50995900.0 6099400.0 10149400.0 34747100.0 True False 7895793.53714871 9584576.967960363 28423484.335353695 1.0 1.2138839399569075 3.599826186136301 22.91265283535633 -6.92447441619442 0.7908349602356352 0.9553504340972379 4.027174165989654 0.9953362713734264 0.0804744553998067 0.09560993746911957 0.09249246888730782 0.0710343552398098 0.22280392624336717 1.189941425223131e-07 6.92447441619442 3.0718237318924158 up GNAGGIQPDLLISLTAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNAGGIQPDLLISLTAPK 18 0 Q8NCW5-2;Q8NCW5 Q8NCW5-2 APOA1BP NAD(P)H-hydrate epimerase 0 19080700.0 5102500.0 9741400.0 4236800.0 False True 6689426.9126802925 8288021.091679788 3798416.5782553526 1.0 1.238973263310381 0.5678239149388387 22.67345118891304 -6.810447840607613 1.4127762037579499 1.1301669673687045 0.555974512811174 0.8609705725830856 0.10356518252668333 0.20618555595159818 0.8110325195286302 0.05764150954206818 0.1333019383950708 1.547220316176535e-07 6.810447840607613 -0.5741924545575304 GNAGGIQPDLLISLTAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNAGGIQPDLLISLTAPK 18 0 Q8NCW5-2;Q8NCW5 Q8NCW5-2 APOA1BP NAD(P)H-hydrate epimerase 0 26291400.0 7744800.0 6709600.0 11837000.0 False True 7498945.56328919 9388778.27010177 8736534.59761177 1.0 1.2520131251604476 1.1650350737817263 22.838256319924728 -10.073951796438248 4.440493592077519 0.9999842040616757 1.208524099435734 0.8845743198777478 0.03550864083626912 24653336.632016692 0.4121734061503967 4060.3653267504073 0.012155552224850805 8.434283670475527e-11 10.073951796438248 0.20853989537405837 GNAGGIQPDLLISLTAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNAGGIQPDLLISLTAPK 18 0 Q8NCW5-2;Q8NCW5 Q8NCW5-2 APOA1BP NAD(P)H-hydrate epimerase 0 27539300.0 5102500.0 9180800.0 13256000.0 False True 6989032.139877734 8775161.899154302 10125205.815889703 1.0 1.255561817935468 1.4487278943986703 22.736661250435933 -6.974220711096582 0.1202937507186784 0.6539856131838037 2.0552683873308806 0.9999994409023405 0.00013729751016278526 0.07495534500439004 0.003583046453059741 0.013560778100153298 0.027796435122335553 1.0611561341411948e-07 6.974220711096582 1.4012827741470768 GNAGGIQPDLLISLTAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNAGGIQPDLLISLTAPK 18 0 Q8NCW5-2;Q8NCW5 Q8NCW5-2 APOA1BP NAD(P)H-hydrate epimerase 0 19278600.0 7744800.0 5167000.0 6366800.0 False True 6440144.352814356 5139164.3454308035 7698068.443242874 1.0 0.7979889989864868 1.1953254494798402 22.618661595359004 -6.768473017067052 1.5801388606718818 0.8839083754535149 1.1974415944266033 0.7247647967994761 0.08510503671243146 0.26889459316224806 1.324746117058967 0.04245782128181016 0.10121605154423832 1.704225200388682e-07 6.768473017067052 0.3135332189730884 GNDISSGTVLSDYVGSGPPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNDISSGTVLSDYVGSGPPK 20 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 69019300.0 7127300.0 33790000.0 28102000.0 False True 9343959.32087138 28748663.712388415 25194274.613418624 1.0 3.076711137662298 2.6963168126323893 23.15560256275177 -10.050032852560811 5.5442073422395035 0.999989794300384 2.886513975148285 0.9704087062517511 0.1552953328989325 1.959078666778892e-05 3.356767868768901e-06 0.15036487022860648 0.050121353171293674 8.911835212784989e-11 10.050032852560811 1.8865241808479012 GNDISSGTVLSDYVGSGPPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNDISSGTVLSDYVGSGPPK 20 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 80234100.0 25808000.0 9422100.0 45004000.0 False True 24988739.166585002 13184393.665602386 33216102.308939815 1.0 0.5276134012888728 1.3292428276395978 24.574774774759636 -6.747012213128748 1.660773263863997 0.7212375156754516 1.3304915322470579 0.6360525896433268 0.19847834780862955 0.3052936853107915 1.6557546537688805 0.0944431638031939 0.23001795132423397 1.7905554997405686e-07 6.747012213128748 0.6092540165716063 GNDISSGTVLSDYVGSGPPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNDISSGTVLSDYVGSGPPK 20 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 67121300.0 7127300.0 29263000.0 30731000.0 False True 9762455.418040281 27970063.90019956 23472970.724811893 1.0 2.86506444357359 2.40441259085656 23.218812624274662 -10.145407191343011 5.205380609712128 0.9999417965581672 2.6347385172163684 0.943793407552395 0.18806033137527547 0.00012703837238839754 2.0856376500356826e-05 0.1820950242496557 0.06069621095757114 7.154722740429361e-11 10.145407191343011 1.6347967206582013 GNDISSGTVLSDYVGSGPPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNDISSGTVLSDYVGSGPPK 20 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 40326600.0 25808000.0 7032100.0 7486500.0 False True 21460495.488254443 6994216.68153744 9051892.536335004 1.0 0.32591123934512367 0.4217932685333012 24.355180050193912 -10.77858220174574 7.154442889787464 1.0163138261240265 0.37385225393921245 0.9827173362505541 0.039143674502279686 0.009746900008887862 0.0003016495098246443 0.0362675837486653 0.012633566621391094 1.6650136499780574e-11 10.77858220174574 -0.6424615721848141 GNDISSGTVLSDYVGSGPPK(ub)GTGLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNDISSGTVLSDYVGSGPPKGTGLHR 26 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 1 28158000.0 10203000.0 9268600.0 8686400.0 True False 9879111.349839846 12969600.315110479 6411171.253585788 1.0 1.3128306641994407 0.6489623435299899 23.23594984303299 -6.778569254176944 1.5414442138174713 1.177463732270773 0.6439384125246284 0.762279771986393 0.13221447479429613 0.25281243960880745 1.1863908025292769 0.06756339173919847 0.15961302857432014 1.6650632895683197e-07 6.778569254176944 -0.5335253197461447 GNDISSGTVLSDYVGSGPPK(ub)GTGLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNDISSGTVLSDYVGSGPPKGTGLHR 26 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 1 19282900.0 6612900.0 7166400.0 5503600.0 True False 9057867.83690299 6849764.751884304 4203763.030199953 1.0 0.7562226425933737 0.4641007250153562 23.11074005854266 -6.968719947326898 0.2871188826101197 1.059081745927328 0.1522523642873023 0.9999706044236101 0.0011877681343256295 0.07672027515725825 0.01050955676088575 0.0051840096499713014 0.026580497889475686 1.0746821925062925e-07 6.968719947326898 -0.9068293816400258 down GNDISSGTVLSDYVGSGPPK(ub)GTGLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNDISSGTVLSDYVGSGPPKGTGLHR 26 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 1 25043900.0 10203000.0 11419000.0 3421900.0 True False 8484246.569538904 11357483.580505967 4137403.4689220292 1.0 1.338655529093518 0.4876571461014111 23.016355118467267 -6.798762020458691 1.4613630877763177 1.187146051249327 0.4763183720100229 0.8284018180962843 0.14491184275656666 0.22253404687006928 0.938426938448845 0.07802189923463944 0.1815563845672105 1.589417460150982e-07 6.798762020458691 -0.7108276792393041 down GNDISSGTVLSDYVGSGPPK(ub)GTGLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNDISSGTVLSDYVGSGPPKGTGLHR 26 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 1 41939000.0 16898000.0 13577000.0 11464000.0 True False 21874794.109377757 12821428.014857827 9377669.630573345 1.0 0.5861279402561902 0.4286975037883042 24.382766102240957 -13.999999999999998 0.1339873945041213 2.969083368819635 0.21899795003581177 0.999627953503632 0.0046473346259231114 11.932585655107214 0.11420597279975689 6.167505636743682 0.18681353736930123 1.0000000000000041e-14 13.999999999999998 -2.7500854187838235 GNDK(ub)GDESQSQSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNDKGDESQSQSVR 14 1 Q96GM8;Q96GM8-2 Q96GM8 TOE1 Target of EGR1 protein 1 1 4965650.0 1631600.0 2382600.0 951450.0 True False 1356747.6921356143 2369764.460890927 1150393.795992246 1.0 1.7466508140218424 0.8479054747323335 20.37172102394343 -6.686184632858943 1.8800556442599827 1.469773219463427 0.8511556709119741 0.352562094916386 0.31603077735173035 0.42493923377942144 2.909039935619618 0.134629065746124 0.3522681686215021 2.0597540579543194e-07 6.686184632858943 -0.6186175485514529 GNDTPLALESTNTEK(ub)ETSLEETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNDTPLALESTNTEKETSLEETK 23 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 16543600.0 5688800.0 7737000.0 3117800.0 True False 7458071.890417575 6582669.758589787 2795199.964049412 1.0 0.8826235326381691 0.3747885519367003 22.830371273039248 -6.943076917621591 0.6302989074834817 1.005539708148726 0.22448929980795435 0.9985396644579925 0.010368563256832965 0.0863908056173051 0.04842691333840469 0.010345946847583927 0.04315104348937587 1.1400478565234143e-07 6.943076917621591 -0.7810504083407717 down GNDTPLALESTNTEK(ub)ETSLEETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNDTPLALESTNTEKETSLEETK 23 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 16243200.0 5654600.0 4830500.0 5758100.0 True False 5475097.818171549 6759343.840724727 4249880.87070275 1.0 1.23456129282126 0.7762200807805897 22.38445330947732 -6.7675998692604455 1.583590716538061 1.1349541306852373 0.7738713908185103 0.7212692352617764 0.09879746075506562 0.27035246920948414 1.3376334280675268 0.0491859903131556 0.11734515616787707 1.70765498688446e-07 6.7675998692604455 -0.361082739866727 GNDTPLALESTNTEK(ub)ETSLEETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNDTPLALESTNTEKETSLEETK 23 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 37950000.0 12084000.0 12210000.0 13656000.0 True False 18332311.458734598 10031030.102834582 10956885.61436257 1.0 0.5471775954392923 0.5976816201833655 24.127885366063826 -10.832315985903534 11.030199910577231 1.0060453218418466 0.5724296078113289 0.9896443544085899 0.02061818176331249 0.003036936871262188 4.616821998990556e-05 0.01977954959178864 0.00665448954986556 1.4712416603895122e-11 10.832315985903534 -0.4336157140305177 GNDTPLALESTNTEK(ub)ETSLEETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNDTPLALESTNTEKETSLEETK 23 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 11186800.0 5688800.0 3021500.0 2476500.0 True False 7792103.094039487 2888000.1392356567 1891601.7051185006 1.0 0.3706316644404784 0.2427588139286129 22.89358133456214 -13.999999999999927 0.22402875645245524 4.866351029623078 0.17694501454711434 0.9995022467840913 0.007384065076622669 13.112345843234113 0.14991137741117572 22.476625407598558 0.06893389645593959 1.0000000000001677e-14 13.999999999999927 -4.6894060150759636 GNDTPLALESTNTEK(ub)ETSLEETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNDTPLALESTNTEKETSLEETK 23 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 17111000.0 5654600.0 7795700.0 3660700.0 True False 4702050.441254006 7753703.0167747075 4426135.444835584 1.0 1.6490046446007172 0.9413202814674958 22.164858584911595 -6.665563303180649 1.9534737783367444 1.4158405176069917 0.9442544364314499 0.2593595559051711 0.27597074262875243 0.47140473814138706 3.463819428126822 0.11391651213925484 0.30608664357220444 2.15991518051812e-07 6.665563303180649 -0.4715860811755418 GNDTPLALESTNTEK(ub)ETSLEETK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNDTPLALESTNTEKETSLEETK 23 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 38118000.0 12084000.0 13916000.0 12118000.0 True False 15642976.21125111 13141562.366852865 9912648.341180013 1.0 0.8400934828118501 0.6336804587128634 23.899011688156275 -6.967632519498624 0.30955822701889024 1.031965988633793 0.4352508806415542 0.9999575819996632 0.0009765972449265606 0.07707863048731335 0.01176595777252242 0.0032724081570334705 0.018333398683187094 1.0773764556583106e-07 6.967632519498624 -0.5967151079922388 GNECFQK(ub)GDYPQAMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNECFQKGDYPQAMK 15 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 4920000.0 1819100.0 1994200.0 1106700.0 True False 2384857.7161894576 1696673.133330718 992189.3002160124 1.0 0.7114357899898842 0.416037105056875 21.18547176500102 -6.970832710903428 0.23745677673729304 1.1094715928823913 0.00948408630225242 0.9999881681687316 0.00082003948169812 0.07603344083064321 0.008057048304359965 0.007190089665738321 0.028930511790657667 1.0694667556829702e-07 6.970832710903428 -1.0999875065801388 down GNECFQK(ub)GDYPQAMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNECFQKGDYPQAMK 15 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 5435200.0 1819100.0 2041500.0 1574600.0 True False 2491670.429329069 1951299.779662284 1202711.9099049435 1.0 0.7831291637504844 0.48269301419160693 21.24868182652391 -6.966545264239924 0.33046041047960867 1.0364067520074092 0.21957348624447395 0.9999415443230839 0.0016216755030116958 0.0774404415085892 0.013031916830087174 0.0043766756045690875 0.02619500186519471 1.0800770442402151e-07 6.966545264239924 -0.8168332657629352 down GNECFQK(ub)GDYPQAMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNECFQKGDYPQAMK 15 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 5169600.0 2514900.0 1456600.0 1198100.0 True False 2091250.77896044 1448753.0066875364 1448617.1706114998 1.0 0.6927686632627154 0.6927037087974723 20.99593464697078 GNEFEDYCLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNEFEDYCLKR 11 1 P26196;Q8IV96 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 1 3734950.0 564650.0 1585600.0 1584700.0 True False 740261.6180783779 1349034.66062039 1420730.4455157833 1.0 1.8223755327505795 1.9192274877141586 19.497675702477302 -11.083988684634779 0.3846709244112117 8.027299894292511e-15 1.9290755921256721 0.9995029539037111 0.009194254069627959 2.9766882228612186 0.19048726120551004 2.6275249498538 0.025829754402342232 8.241595878744794e-12 11.083988684634779 1.9290755921256642 GNEFEDYCLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNEFEDYCLKR 11 1 P26196;Q8IV96 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 1 3824450.0 564650.0 1432000.0 1827800.0 True False 773416.3640924955 1368729.505009254 1396111.2847226313 1.0 1.7697188326436326 1.805122505212038 19.560885764000194 -11.182600648462746 0.522693037826711 1.0613761226612303e-12 1.8028244749323608 0.9998533309527503 0.0044988178680565585 3.2863788837908667 0.25579239021321504 3.856192160137084 0.006913796274150459 6.56748896198e-12 11.182600648462746 1.8028244749312994 GNEFEDYCLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNEFEDYCLKR 11 1 P26196;Q8IV96 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 1 5096580.0 1108300.0 924780.0 3063500.0 True False 921600.556014893 919798.0265855414 3704063.6859763972 1.0 0.998044131573503 4.019163901108302 19.813782061616003 -6.906746882742962 0.9175851758556203 0.8965665849053047 4.383621704236564 0.9896353895287691 0.14494313241060802 0.1066092537139548 0.15071997115288716 0.1167903215174272 0.31557750784178124 1.2395187973808774e-07 6.906746882742962 3.4870551193312593 up GNEIVLSAGSTPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNEIVLSAGSTPR 13 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 10521900.0 2858300.0 3160200.0 4503400.0 False True 3747258.979816578 2688710.478363121 4037431.367663135 1.0 0.7175139195996346 1.0774359043261965 21.837404257689276 -6.697357866093533 1.8400668084728458 0.8241390228234527 1.0763221381553405 0.40516807415182243 0.11929898869321565 0.40103479406267767 2.637899981944101 0.05175739760536287 0.133553359050887 2.0074379676147938e-07 6.697357866093533 0.25218311533188775 GNENANGAPAITLLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNENANGAPAITLLIR 16 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 36140000.0 10664000.0 14370000.0 11106000.0 False True 13980607.270322915 12226052.013821274 9956857.65627454 1.0 0.8745007836515019 0.7121906412041401 23.736923692081934 -6.9676037015064916 0.31013109639403025 1.0249665448822127 0.5565645409208259 0.9999571955684398 0.0007708010958511312 0.07708819257464736 0.01179938367664888 0.002566552024680298 0.014408214590947127 1.0774479482920925e-07 6.9676037015064916 -0.46840200396138687 GNENANGAPAITLLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNENANGAPAITLLIR 16 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 33394300.0 12712000.0 9637300.0 11045000.0 False True 12308464.518196989 13485524.14785559 8151983.1571024945 1.0 1.0956300948764504 0.6623070769754018 23.55314746095251 -6.84883120847548 1.2406932257727348 1.0509850183245464 0.645368478699605 0.9385944256474382 0.0460604572555742 0.1587434995594818 0.4708103812860945 0.029058640407620937 0.06719616284000499 1.4163441448498915e-07 6.84883120847548 -0.4056165396249414 GNENANGAPAITLLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNENANGAPAITLLIR 16 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 88706000.0 18565000.0 42754000.0 27387000.0 False True 28164462.283300873 35124214.66147331 21973947.445851468 1.0 1.2471111398529693 0.7802012062158257 24.747372592077987 -6.762935573280742 1.6015558629805575 1.1430151019916492 0.7782528078597245 0.7027509546764592 0.10398369786013541 0.2780314250164977 1.4061851899984357 0.051213217432212924 0.12271265808817004 1.7260939355869028e-07 6.762935573280742 -0.36476229413192474 GNENANGAPAITLLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNENANGAPAITLLIR 16 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 52938000.0 10664000.0 12216000.0 30058000.0 False True 14606768.983764075 11676256.727090117 22958919.4639418 1.0 0.7993729989204784 1.5717999983063626 23.800133753604825 -6.8377505089871145 1.292979201342151 0.8932250546143836 1.596066951964075 0.9204850974849363 0.09228002711642215 0.171445633035713 0.5577643758245641 0.05598613714738118 0.12890136305291475 1.4529460580333963e-07 6.8377505089871145 0.7028418973496915 GNENANGAPAITLLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNENANGAPAITLLIR 16 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 29052400.0 12712000.0 5620400.0 10720000.0 False True 10570591.237085009 5590121.789637949 12961502.436320215 1.0 0.5288371921928091 1.2261851911222454 23.333552736386785 -6.724724476598337 1.7423924790461263 0.7148011132552702 1.2253911037595686 0.5346465503460421 0.1981615266355783 0.34623393624650717 2.056699240627941 0.09021794702979015 0.22522546401871668 1.8848444859056873e-07 6.724724476598337 0.5105899905042984 GNENANGAPAITLLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNENANGAPAITLLIR 16 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 60226000.0 18565000.0 24251000.0 17410000.0 False True 24032758.470860377 22901410.531657703 14241558.641685426 1.0 0.9529247572402298 0.5925894299213824 24.518498914170436 -6.930927558345114 0.7391414009181742 1.005295464603456 0.5168369428267549 0.9967173498837739 0.01042627035516348 0.09215923235508275 0.07534243064502873 0.009551749306298134 0.03243948309787812 1.1723909076472561e-07 6.930927558345114 -0.4884585217767011 GNFGGSFAGSFGGAGGHAPGVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNFGGSFAGSFGGAGGHAPGVAR 23 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 418984900.0 121973900.0 107160000.0 189851000.0 False True 159908964.0969279 91172145.70640846 170207039.69938564 1.0 0.5701503115931948 1.0643996142468637 27.252675574062838 -6.676761285295663 1.9131342712136905 0.7272477884751489 1.0624858710495388 0.3094828131805777 0.18230997649343758 0.44575615650766587 3.1513953582154373 0.07653983081505746 0.2027294400743639 2.1049351224209963e-07 6.676761285295663 0.3352380825743899 GNFGGSFAGSFGGAGGHAPGVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNFGGSFAGSFGGAGGHAPGVAR 23 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 328209500.0 109794400.0 44837900.0 173577200.0 False True 106309036.87041612 62741907.29655949 128112124.11561869 1.0 0.5901841380901404 1.2050915697014464 26.663688998432548 -6.72707272415009 1.7339462266645163 0.7525698551249325 1.2045303616623075 0.5455889084501049 0.1723205981861501 0.341770988160009 2.0117046687324276 0.07880008845020643 0.19618526396036826 1.8746805598788564e-07 6.72707272415009 0.4519605065373751 GNFGGSFAGSFGGAGGHAPGVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNFGGSFAGSFGGAGGHAPGVAR 23 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 469600400.0 92049400.0 217014000.0 160537000.0 False True 139645669.512549 178286156.161879 128806791.58413342 1.0 1.276703794569567 0.9223830000153239 27.05719559465991 -6.698362357446968 1.8368285808625384 1.17210015060474 0.9234736653874274 0.4097236662231605 0.11683595158708619 0.3989557065698379 2.615791246221263 0.05076818088043211 0.1308211903440368 2.0028002758953812e-07 6.698362357446968 -0.24862648521731257 GNFGGSFAGSFGGAGGHAPGVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNFGGSFAGSFGGAGGHAPGVAR 23 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 384090700.0 121973900.0 135601800.0 126515000.0 False True 167070947.05070704 129610464.1008128 96634762.65821402 1.0 0.7757809863942127 0.5784055478471957 27.31588563558573 -6.972625303169125 0.1850273128354551 1.142782138400295 0.2060399198119367 0.9999962777961585 0.0003322362519151843 0.07545966439727446 0.005868634975347461 0.007272952856917777 0.021821583746329178 1.0650615264934112e-07 6.972625303169125 -0.9367422185883583 GNFGGSFAGSFGGAGGHAPGVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNFGGSFAGSFGGAGGHAPGVAR 23 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 225154400.0 109794400.0 50891700.0 64468300.0 False True 91298908.3166306 50617536.31088851 77948323.46225958 1.0 0.5544155701768478 0.8537705970363816 26.444094273866824 -9.926435349847873 5.417373648283838 1.0000004521205748 0.7040930836053553 0.5657449777476395 0.1222111779615929 6.673687871107586e-07 1.321463756088148e-07 0.11833064585170674 0.03944348807982965 1.1845806934883446e-10 9.926435349847873 -0.2959073685152195 GNFGGSFAGSFGGAGGHAPGVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNFGGSFAGSFGGAGGHAPGVAR 23 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 558236400.0 92049400.0 255904000.0 210283000.0 False True 119159762.86494009 241662717.44230473 172013651.6857864 1.0 2.028056381047131 1.4435548338641189 26.82832191675236 -10.539106930335256 5.103902311760393 0.9967310378767313 1.7358056074556343 0.6787634988034977 0.23862175741098085 0.008902334491969196 0.0008038985287245694 0.2317264402487445 0.07701484104128484 2.889968237773938e-11 10.539106930335256 0.7390745695789029 GNFILSAGVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNFILSAGVDK 11 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 20966400.0 6271400.0 6549600.0 8145400.0 False True 8221866.132323993 5572425.210140837 7302592.144194012 1.0 0.6777567428680251 0.8881915646235242 22.97103445158791 -10.155436246839983 4.890656750015848 1.0000160708940573 0.7829741537450374 0.5864631081523151 0.0859096562382969 1.5055110222990426e-05 2.599697761069023e-06 0.08318782364036452 0.02772722232374761 6.991393608431441e-11 10.155436246839983 -0.21704191714901988 GNFILSAGVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNFILSAGVDK 11 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 16076100.0 4496300.0 2300100.0 9279700.0 False True 4353567.417650186 3218541.9248630456 6849068.184967316 1.0 0.7392884078961238 1.5732082515134362 22.053766633851858 -6.822707809973196 1.3602554314100423 0.8598527766099412 1.5924720295332562 0.890469999737211 0.11527861799646999 0.18998647262857865 0.6900093904501019 0.06658636176718427 0.15336076883263575 1.5041536088556103e-07 6.822707809973196 0.732619252923315 GNFILSAGVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNFILSAGVDK 11 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 44729100.0 8914100.0 22685000.0 13130000.0 False True 13523341.408002807 18636684.511286024 10534849.744916568 1.0 1.3781124020323303 0.7790123333484935 23.688948327455478 -6.736127532922763 1.700881170262033 1.22597808082624 0.778949611764891 0.5874385411411662 0.15888783133711004 0.3248645886294094 1.8438036808777347 0.07394749547675171 0.18223711079263374 1.835999113111804e-07 6.736127532922763 -0.44702846906134897 GNFILSAGVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNFILSAGVDK 11 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 21164500.0 6271400.0 8107900.0 6785200.0 False True 8590106.058212487 7749666.168760139 5182675.505580479 1.0 0.9021618727688636 0.603330793643186 23.034244513110803 -6.951046261172076 0.5472357239184994 1.00420208812775 0.48731829824340667 0.9992808588308411 0.004524711994046547 0.08306829391759449 0.0342443960037933 0.004928644682390874 0.024777918361784095 1.1193186469751993e-07 6.951046261172076 -0.5168837898843434 GNFILSAGVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNFILSAGVDK 11 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 10633200.0 4496300.0 2678100.0 3458800.0 False True 3738872.669863544 2663672.543738774 4182019.0883157067 1.0 0.7124266534158247 1.1185240733186925 21.834171909286134 -6.716454138054711 1.771856574804334 0.8243888342675777 1.1177785188892941 0.49585540116396 0.12106712180375434 0.36224104833450316 2.2205224315141954 0.05429218628497491 0.13687662911491713 1.9210818192626664e-07 6.716454138054711 0.29338968462171644 GNFILSAGVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNFILSAGVDK 11 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 33936700.0 8914100.0 15342000.0 9680600.0 False True 11539478.173180519 14488204.213298105 7918830.131344064 1.0 1.2555337421557649 0.6862381480774942 23.460074649547927 -6.784670775957116 1.5174584186258437 1.143814104635715 0.6810334201653493 0.783619589382915 0.10829965456528594 0.24339394987394541 1.1071965776678092 0.05619332200550426 0.13209658853980172 1.6418339206527403e-07 6.784670775957116 -0.4627806844703658 GNFK(ub)LVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNFKLVR 7 1 P41091;H7BZU1 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 1739280.0 799580.0 939700.0 0.0 True False 1095206.3338370284 898180.94682765 0.0 1.0 0.8201020383811105 0.0 20.062771264503084 -7.220247639383129 0.875921491248686 0.9899931233594529 6.830133995896884e-16 0.9891436365204687 0.045349686179725776 0.09505325195218323 0.13936052974083876 0.0382997963364813 0.06730227329583253 6.02216098059225e-08 7.220247639383129 -0.9899931233594522 down GNFK(ub)LVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNFKLVR 7 1 P41091;H7BZU1 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 7359300.0 1118500.0 3153500.0 3087300.0 True False 930082.3079515105 3136511.4695792603 3732840.1559376344 1.0 3.372294519274719 4.013451416100095 19.826998868097387 -9.648799020735366 0.36400368022002344 1.415936753295302e-20 4.140815155749372 0.9985308478597325 0.04968033035618136 0.9909394016990144 0.15315618370768716 1.3743933326889133 0.17998848092744565 2.2449205695009142e-10 9.648799020735366 4.140815155749372 GNFK(ub)LVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNFKLVR 7 1 P41091;H7BZU1 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 16965000.0 2682700.0 2962300.0 11320000.0 True False 3472808.0339228157 2797445.400929017 9259876.153008563 1.0 0.8055283717393034 2.6663944746029595 21.727671234532558 -6.8810891052042304 1.0736705139326082 0.8776327428356434 2.8010776717222963 0.9745548826747354 0.13322163635631196 0.12667134864581467 0.26647401886244865 0.09548407199392549 0.2315642663052412 1.3149550121494604e-07 6.8810891052042304 1.9234449288866529 up GNFLEIK(ub)NK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNFLEIKNK 9 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y7I0;A0A2R8Y7M9 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 2293940.0 963840.0 0.0 1330100.0 True False 1263603.5738398368 0.0 1192474.01122013 1.0 0.0 0.9437089573879897 20.269112491890162 -11.805869084654777 16.83056499323662 0.8508191560518008 0.5246690308246267 0.0 0.4749777476253924 0.0 0.0 0.0 0.13453431139158362 1.563618914712377e-12 11.805869084654777 -0.3261501252271741 GNFLEIK(ub)NK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNFLEIKNK 9 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y7I0;A0A2R8Y7M9 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 5906100.0 1593300.0 1656700.0 2656100.0 True False 1542721.563628325 2318228.949576365 1960387.7287080043 1.0 1.502687849986439 1.2707333422483387 20.55704627153061 -10.105979395089 4.440984670312229 0.9999619195166861 1.3867105961000634 0.7875052466891131 0.09469503133901855 10675029.48956371 24292279.30278503 2449.1856227821913 0.03241662761047989 7.834668131233773e-11 10.105979395089 0.3867486765833773 GNFLEIK(ub)NK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNFLEIKNK 9 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y7I0;A0A2R8Y7M9 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 5305800.0 1593300.0 2089400.0 1623100.0 True False 1324899.5451579255 2078143.98748657 1962482.7056335232 1.0 1.5685294746167786 1.481231322635558 20.337451546964886 -10.66524771704489 6.480750618531095 0.9964468439479418 1.5248803986261659 0.9796749020050869 0.035639321306987805 0.0018368746036972073 9.488050107579145e-05 0.03464365508965927 0.01150254149100824 2.1614852833749192e-11 10.66524771704489 0.5284335546782241 GNFNYIEFTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNFNYIEFTR 10 0 J3QRS3;P19105;O14950 J3QRS3 MYL12A;MYL12B Myosin regulatory light chain 12A;Myosin regulatory light chain 12B 0 118212000.0 35022000.0 29266000.0 53924000.0 False True 45914181.153530434 24899626.877974518 48344461.75553287 1.0 0.5423079809419608 1.052930936389259 25.452436480596354 -6.670453993179785 1.9360657655959348 0.7079682746537866 1.0508582423148223 0.2809724346259378 0.19439765616415786 0.460048813601715 3.325055269816106 0.0808279400745191 0.21580045771546416 2.1357283216289023e-07 6.670453993179785 0.34288996766103563 GNFNYIEFTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNFNYIEFTR 10 0 J3QRS3;P19105;O14950 J3QRS3 MYL12A;MYL12B Myosin regulatory light chain 12A;Myosin regulatory light chain 12B 0 88539000.0 25681000.0 11308000.0 51550000.0 False True 24865770.71206871 15823343.370440995 38047508.53314921 1.0 0.6363504093103001 1.5301157954731195 24.567657812233275 -6.7962268842744935 1.4711477171407006 0.7983914406802034 1.541353090137693 0.8209492162666308 0.15528609289446377 0.2261793057834189 0.966746746888466 0.08305344066660368 0.19362276481545823 1.5987226051923584e-07 6.7962268842744935 0.7429616494574897 GNFNYIEFTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNFNYIEFTR 10 0 J3QRS3;P19105;O14950 J3QRS3 MYL12A;MYL12B Myosin regulatory light chain 12A;Myosin regulatory light chain 12B 0 105969000.0 35022000.0 26316000.0 44631000.0 False True 47970579.83396331 25153272.10462536 34090077.004297964 1.0 0.5243478855516516 0.7106455065227727 25.515646542119246 -10.136423029560243 5.250876868318361 1.000011171174936 0.6174966960369419 0.8489597775132443 0.07605568527989003 9.94661730374156e-06 1.6359942264597914e-06 0.07364274895074063 0.024546866872647673 7.304272557459859e-11 10.136423029560243 -0.3825144751379941 GNFNYIEFTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNFNYIEFTR 10 0 J3QRS3;P19105;O14950 J3QRS3 MYL12A;MYL12B Myosin regulatory light chain 12A;Myosin regulatory light chain 12B 0 54455000.0 25681000.0 14213000.0 14561000.0 False True 21354889.36120049 14136431.747940386 17605637.777542815 1.0 0.6619763515902238 0.8244312335108765 24.34806308766755 -10.07465617390904 4.8769866567947835 1.0000078831370034 0.7432037925482364 0.7691374257808 0.06632192782960353 92099899.35727113 3.5583567803439893 8153.102297561434 0.02270375995473212 8.420615285325443e-11 10.07465617390904 -0.25680409058876696 GNFNYIEFTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNFNYIEFTR 10 0 J3QRS3;P19105;O14950 J3QRS3 MYL12A;MYL12B Myosin regulatory light chain 12A;Myosin regulatory light chain 12B 0 57524000.0 18799000.0 26241000.0 12484000.0 False True 24335676.083689988 24780665.28230715 10212040.096657144 1.0 1.0182854668630061 0.41963247955545213 24.53656951974177 -6.8998532757375655 0.9621828087078952 1.0249901011183407 0.35697799043669554 0.9864935254198713 0.03230819812331832 0.11151377363967677 0.17802432566227197 0.025190380983526706 0.06549383511892469 1.259350805429662e-07 6.8998532757375655 -0.6680121106816451 down GNGGVYGWDLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNGGVYGWDLKR 12 1 Q5QPK2;H0Y368;O60762 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 1 41031700.0 12322000.0 20673800.0 8035900.0 True False 15951071.902932491 19523284.856269233 6573448.655296958 1.0 1.2239481443676532 0.4121007475421433 23.927150039743015 -6.83313736727748 1.3137498228500022 1.119429900736149 0.3888076794648049 0.9120189763389216 0.10154853131308027 0.17697146457457474 0.5962332875972752 0.0606681683135871 0.13962314193664524 1.46846172996141e-07 6.83313736727748 -0.7306222212713441 down GNGLIK(ub)VNGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNGLIKVNGR 10 1 P62249;M0R3H0;M0R1M5;Q6IPX4 P62249 RPS16 40S ribosomal protein S16 1 2593320.0 401620.0 759700.0 1432000.0 True False 526527.7092936126 646355.7212874069 1283830.3767139516 1.0 1.227581587594991 2.438295941606441 19.006149931629995 -6.938432715771901 0.6739965656203636 0.9859712094851258 2.7502541024057394 0.9979511948139456 0.028572843154633654 0.08848916076828713 0.057922828977724834 0.027493572603842883 0.10494385734776777 1.1523045698487019e-07 6.938432715771901 1.7642828929206136 up GNGLIK(ub)VNGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNGLIKVNGR 10 1 P62249;M0R3H0;M0R1M5;Q6IPX4 P62249 RPS16 40S ribosomal protein S16 1 5219620.0 682520.0 1399300.0 3137800.0 True False 660853.77619256 1958047.7872531028 2315916.0480177645 1.0 2.962906255199434 3.504430376959746 19.333971563569534 -9.774399097605558 0.3405349924669515 2.6366382025127757e-24 3.638013778379316 0.9986780301423774 0.039119245098458724 1.1285630111984777 0.1462816940113056 1.366605237475502 0.16453032485812918 1.6811284675892886e-10 9.774399097605558 3.638013778379316 GNGLIK(ub)VNGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNGLIKVNGR 10 1 P62249;M0R3H0;M0R1M5;Q6IPX4 P62249 RPS16 40S ribosomal protein S16 1 3193830.0 401620.0 752630.0 2039580.0 True False 550109.7673724047 719376.3179854158 1557873.2104686429 1.0 1.3076959557026437 2.831931557786754 19.069359993152887 -6.940012858612532 0.6594427582951792 0.982894849892138 3.243126460163516 0.9981655984156206 0.0343053803634211 0.08776074373049554 0.05458271670251989 0.03339698623802922 0.1311804550817916 1.1481196274108391e-07 6.940012858612532 2.260231610271378 up GNGLIK(ub)VNGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNGLIKVNGR 10 1 P62249;M0R3H0;M0R1M5;Q6IPX4 P62249 RPS16 40S ribosomal protein S16 1 6149680.0 682520.0 3332700.0 2134460.0 True False 567545.6207626866 3314746.0836108406 2580765.7173720207 1.0 5.840492750444229 4.547239240263897 19.11437683900381 -10.034679301971881 6.852877823648841 0.9999989854523375 5.193865995354068 0.9334296145565604 0.5279685346675301 8.204570242121904e-06 1.1560439641241344e-06 0.5112034572683204 0.17040111184073684 9.232529373186132e-11 10.034679301971881 4.193867009901731 GNGLIK(ub)VNGRPLEMIEPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNGLIKVNGRPLEMIEPR 18 2 P62249;M0R3H0;M0R1M5;Q6IPX4 P62249 RPS16 40S ribosomal protein S16 1 4155300.0 1020500.0 2071200.0 1063600.0 True False 1337885.382536059 1762185.033474365 953548.8747716187 1.0 1.3171420036999097 0.7127283751049717 20.35152309402568 -6.764138382562432 1.5970357221698435 1.183261334479679 0.7100661900752429 0.7076063468359077 0.13348095555281453 0.27600442244689877 1.3883055658043182 0.06592008588580535 0.15776680071310423 1.7213200102733648e-07 6.764138382562432 -0.4731951444044361 GNGTSMISLIIPPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNGTSMISLIIPPK 14 0 P62495;D6RCB3 P62495 ETF1 Eukaryotic peptide chain release factor subunit 1 0 7738600.0 2570200.0 2656200.0 2512200.0 False True 3369557.089852206 2259905.3137865057 2252261.642724014 1.0 0.6706831947119877 0.6684147449250671 21.684127538693485 GNGTSMISLIIPPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNGTSMISLIIPPK 14 0 P62495;D6RCB3 P62495 ETF1 Eukaryotic peptide chain release factor subunit 1 0 6626300.0 2570200.0 1499900.0 2556200.0 False True 3520472.39704336 1433629.458493979 1952478.2065915272 1.0 0.4072264448651837 0.5546068783925987 21.747337600216376 -10.279152077146968 8.480326544012135 1.000000400139397 0.4809166616292339 0.9429871782252295 0.060167810035390165 4.5519984343088885e-07 3.869455471261418e-08 0.058257276698866434 0.0194190771870698 5.258331028700708e-11 10.279152077146968 -0.519083738510163 GNIFANLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNIFANLFK 9 0 P84077 P84077 ARF1 ADP-ribosylation factor 1 0 10315200.0 3812200.0 3154100.0 3348900.0 False True 3691183.7976927757 4413548.578414208 2471722.6251535085 1.0 1.1957000302106213 0.6696287046715181 21.815652145818028 -6.805984083441993 1.4314177910711212 1.1071741950588625 0.6612540943904762 0.8490456641715982 0.08434982322427607 0.21234087600549223 0.8582257796068389 0.0463454727162074 0.10741128633247284 1.5632049318469755e-07 6.805984083441993 -0.4459201006683863 GNIFANLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNIFANLFK 9 0 P84077 P84077 ARF1 ADP-ribosylation factor 1 0 7520200.0 3812200.0 2123100.0 1584900.0 False True 3170013.2090949873 2111662.4388976432 1916295.2622503638 1.0 0.6661367949001403 0.6045070275266929 21.596057421252304 -13.999999999999996 0.23761123258880115 3.1845538688080812 0.5766326685151429 0.9995210793237899 0.0038022171969829942 13.540282568173652 0.15429266891097063 14.015827984059772 0.03054318340423456 1.0000000000000082e-14 13.999999999999996 -2.6079212002929384 GNIK(ub)VLMATNRPDTLDPALMRPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNIKVLMATNRPDTLDPALMRPGR 24 3 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 56869000.0 2914700.0 2052300.0 51902000.0 True False 2822174.4439261165 2871794.092603112 38307309.173375614 1.0 1.0175820629315764 13.573685799550981 21.428375735717495 -6.9072011282213275 0.9145592926611091 0.5759935168900133 15.10296405659664 0.9898223977157413 0.5975519328726409 0.10629876609062354 0.14901257362317533 0.48255205049533256 1.3076327913181294 1.2382230142673574e-07 6.9072011282213275 14.526970539706626 up GNIK(ub)VLMATNRPDTLDPALMRPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNIKVLMATNRPDTLDPALMRPGR 24 3 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 271812200.0 2490200.0 61329000.0 207993000.0 True False 3777815.4580056993 50384360.78433595 166883092.38342965 1.0 13.336903653555842 44.17449561486173 21.849120798757546 -6.955465095627025 0.49522996373900285 0.35604836802116424 58.47465594005909 0.9995632818517189 0.3794480174200932 0.08136269614849873 0.027433934159129467 0.4490904226262048 2.5435085067300003 1.1079876110803188e-07 6.955465095627025 58.118607572037924 GNIK(ub)VLMATNRPDTLDPALMRPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNIKVLMATNRPDTLDPALMRPGR 24 3 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 35884300.0 2914700.0 8071600.0 24898000.0 True False 2423702.1931035006 8028116.688712849 30104056.684654936 1.0 3.3123362728128787 12.420691275650212 21.20878101115177 -6.945227663278807 0.6089895504742706 0.899101608570381 15.307438610384203 0.9987715404587622 0.17279234080827452 0.08546057473712039 0.04434287247298258 0.17580782752726157 0.7677681179251932 1.1344159829543261e-07 6.945227663278807 14.408337001813821 GNIK(ub)VLMATNRPDTLDPALMRPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNIKVLMATNRPDTLDPALMRPGR 24 3 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 128515200.0 2490200.0 28038000.0 97987000.0 True False 3223612.989180527 26477660.65261716 80154371.43152398 1.0 8.213659872163511 24.864762519740303 21.620247120849996 -6.957148460052518 0.47392188960700815 0.5765489473873378 33.18900532094382 0.9996493579316341 0.1871319068058227 0.08073603296648672 0.025018431718117542 0.23195954450848882 1.3739587802922062 1.1037012640663579e-07 6.957148460052518 32.61245637355648 GNILIPGINEAVAAVTEEEHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNILIPGINEAVAAVTEEEHK 21 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 33590800.0 15309000.0 7524800.0 10757000.0 False True 14823024.174722936 10529491.8813136 7939418.996917293 1.0 0.7103470760891754 0.5356139815555345 23.82133647870969 -9.982552388142746 0.09345194115344778 1.8031009204416084 2.0831479629858385e-11 0.9999464454003852 0.0014014778595492973 1.5856690826952473 0.04352631368065044 0.5785772115033742 0.2791448607259024 1.0409925270397083e-10 9.982552388142746 -1.8031009204207769 GNILIPGINEAVAAVTEEEHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNILIPGINEAVAAVTEEEHK 21 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 14592700.0 1515500.0 5817200.0 7260000.0 False True 2075821.3048475664 5560176.869092062 5545337.524393429 1.0 2.6785431174194265 2.671394455507161 20.98525082530018 -10.168490092645586 4.308076128167766 0.9995617496795514 2.674968786555632 0.9999863386630728 0.002918429316315632 511313.6923176693 1.8658235912535033 2223.2332965010023 0.0009990559346527794 6.784375971974509e-11 10.168490092645586 1.6754070368760807 GNILIPGINEAVAAVTEEEHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNILIPGINEAVAAVTEEEHK 21 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 19856400.0 15309000.0 2537200.0 2010200.0 False True 12730111.80369215 2523531.600005234 2430523.5258853477 1.0 0.19823326290609067 0.19092711543824903 23.601741754143966 GNINICLMGDPGVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNINICLMGDPGVAK 15 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 43438300.0 9823300.0 17943000.0 15672000.0 False True 12878441.428972524 15265974.341266194 14050411.77643927 1.0 1.1853898956221876 1.0910024985500322 23.618454670804752 -10.116824874694693 5.284014673183685 0.999997022959224 1.1381961970862151 0.7408163211261123 0.03853349349640948 1.3514338992564976e-06 2.2590761874003244e-07 0.0373106985327534 0.01243663154851236 7.641438555292419e-11 10.116824874694693 0.13819917412699112 GNINICLMGDPGVAK ddPTM_RPMI8226_Bortezomib_8h_R1 2 GNINICLMGDPGVAK 15 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 155547800.0 42912800.0 68427000.0 44208000.0 False True 65101854.94591078 56215667.227408774 35470269.42294529 1.0 0.8635033099151321 0.5448426846272723 25.956195314870357 -6.956911480523623 0.4769718425787077 1.0078710256344912 0.38725693328132 0.9996379488972046 0.003628819835136705 0.08082339239781657 0.025352027079357273 0.004465793315489821 0.026290039202668133 1.104303680146111e-07 6.956911480523623 -0.6206140923531711 GNINICLMGDPGVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNINICLMGDPGVAK 15 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 51563300.0 9823300.0 16396000.0 25344000.0 False True 13455239.474700818 15671570.505678587 19358269.176064327 1.0 1.1647188097354209 1.438716063914185 23.681664732327643 -6.96348220947395 0.38321630690410774 0.9818465505733753 1.6313271235766635 0.9998783470800504 0.0019957791036536417 0.07847993939058374 0.016700286203357232 0.0035548967039262087 0.023117498372138206 1.0877216943674962e-07 6.96348220947395 0.6494805730032882 GNINICLMGDPGVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GNINICLMGDPGVAK 15 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 136905500.0 42912800.0 52794900.0 41197800.0 False True 55551465.53775045 49856817.40455308 33700223.1251251 1.0 0.8974887866940696 0.6066486779223464 25.727321636962806 -6.952698203989786 0.5283921606532122 1.0046405792159865 0.48633015282214614 0.99939637112076 0.004093346110671606 0.08242002722410116 0.031615827023403945 0.004577644527642023 0.02404601943376585 1.1150691382234152e-07 6.952698203989786 -0.5183104263938403 GNINICLMGDPGVAK(ub)SQLLSYIDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNINICLMGDPGVAKSQLLSYIDR 24 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 219732000.0 16436000.0 23126000.0 180170000.0 True False 24934613.632552296 18998984.615737278 144559320.52868384 1.0 0.7619522361852034 5.797536013951334 24.57164651250354 -6.895803806148852 0.9873949320986902 0.7658603324701391 6.283318342482965 0.984361106990284 0.29009452565499516 0.11456105599923996 0.19534117011794155 0.22196836197969963 0.5662878447666176 1.2711482205887117e-07 6.895803806148852 5.517458010012826 up GNIVFVTLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNIVFVTLR 9 0 Q9UNX4 Q9UNX4 WDR3 WD repeat-containing protein 3 0 10022200.0 3144700.0 3781600.0 3095900.0 False True 4122732.153318121 3217400.020561349 2775565.9659697795 1.0 0.7804048143103043 0.6732346082041506 21.975169304226615 -13.999999998115568 0.0942379457733831 2.105408688313089 0.4231224020247957 0.9998221757025971 0.001813665529755595 12.126789695341275 0.09020481020177666 2.64903446776272 0.223927606635656 1.0000000043390654e-14 13.999999998115568 -1.6822862862882932 GNIVFVTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNIVFVTLR 9 0 Q9UNX4 Q9UNX4 WDR3 WD repeat-containing protein 3 0 8434700.0 3035600.0 1860700.0 3538400.0 False True 2939236.5396034345 2603687.2134223133 2611586.89027537 1.0 0.885837930476193 0.8885255933255812 21.487010036098717 -10.075024149468515 6.726339175648424 1.0000000677139291 0.8871817619008903 0.9995745197408098 0.0010972337636064912 1.1140522805970095e-09 1.5298189167355256e-10 0.0010623926565700257 0.00035413067444529077 8.413483561542419e-11 10.075024149468515 -0.11281830581303887 GNIVFVTLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNIVFVTLR 9 0 Q9UNX4 Q9UNX4 WDR3 WD repeat-containing protein 3 0 27763700.0 7067600.0 8195100.0 12501000.0 False True 10722065.910770644 6732620.3763914555 10030171.870617049 1.0 0.6279219352334267 0.9354700814272587 23.354079572998664 -9.993242940302439 6.7449768768270175 1.0000000353597014 0.7816960083303418 0.40184003579123384 0.12555600491896537 6.670904958703672e-08 9.937213941034882e-09 0.12156909894356126 0.04052302633895701 1.0156803717554248e-10 9.993242940302439 -0.21830402702935958 GNIVFVTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNIVFVTLR 9 0 Q9UNX4 Q9UNX4 WDR3 WD repeat-containing protein 3 0 16419900.0 3144700.0 5986200.0 7289000.0 False True 4307380.572322099 5721709.890283796 5567488.321667167 1.0 1.328350210578035 1.292546183971329 22.038379365749506 -10.058331907995369 4.402001347799238 0.9999782051612489 1.3104481973080344 0.9901227547550565 0.014616932766177117 2197744.2518070242 2510862.7398918476 374.01897020638506 0.005003764972469404 8.74315327487002e-11 10.058331907995369 0.3104699921467855 GNIVFVTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNIVFVTLR 9 0 Q9UNX4 Q9UNX4 WDR3 WD repeat-containing protein 3 0 8428800.0 3035600.0 1983700.0 3409500.0 False True 2524235.899881633 1973013.4143663796 4122410.68625315 1.0 0.7816279827328731 1.6331321040345155 21.267415311532993 -6.838668789779023 1.2886053662955976 0.8838051365125428 1.6604015248794621 0.9221350911993982 0.10076507448203803 0.17035875598544756 0.5500815173291609 0.06133066918151451 0.141244328261652 1.449877165925815e-07 6.838668789779023 0.7765963883669194 GNIVFVTLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNIVFVTLR 9 0 Q9UNX4 Q9UNX4 WDR3 WD repeat-containing protein 3 0 20609400.0 7067600.0 7678400.0 5863400.0 False True 9149147.523223948 7251090.290143929 4796321.36356453 1.0 0.7925427228862535 0.5242369686781941 23.125205895091113 -6.967604075469511 0.31012884517544653 1.0412718933869658 0.26697762857345003 0.999957198637776 0.0012741489097823932 0.07708811474769295 0.01179924870732041 0.004242664968253465 0.023817448786142142 1.0774470205218086e-07 6.967604075469511 -0.7742942648135158 GNK(ub)ALSVGNIDDALQCYSEAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNKALSVGNIDDALQCYSEAIK 22 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 56317600.0 30123000.0 21829000.0 4365600.0 True False 29166761.85349657 30545433.536731176 3222118.3948072977 1.0 1.0472685891618554 0.11047227014750093 24.797821888732834 -6.8950183772802704 0.9922042461484312 1.044448478195061 0.021503085507030725 0.9839213238315624 0.0546389908547177 0.1151664488584299 0.1988101293668565 0.041656977819927755 0.10591641674176612 1.2734491935535132e-07 6.8950183772802704 -1.0229453926880303 down GNK(ub)ALSVGNIDDALQCYSEAIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNKALSVGNIDDALQCYSEAIK 22 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 63884600.0 31370000.0 23654000.0 8860600.0 True False 47590583.45419592 19432758.89045444 7109298.526261049 1.0 0.4083320161257892 0.14938456329503655 25.504172806066848 -9.463322604205448 0.25362834123370026 1.4068872387034554 2.616214102040817e-17 0.9990534853717744 0.010952736206103646 0.8692734314295835 0.1007708911831263 0.395210766822578 0.1090721446671391 3.4409423447664277e-10 9.463322604205448 -1.4068872387034554 GNK(ub)ALSVGNIDDALQCYSEAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNKALSVGNIDDALQCYSEAIK 22 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 15209900.0 3282000.0 4495000.0 7432900.0 True False 4495444.092715085 4296396.037022763 5677402.105380703 1.0 0.9557222709064759 1.2629235261942182 22.100032212029564 -6.8703233834629795 1.132320436806229 0.9749059565262442 1.2810305673297018 0.9650080944298145 0.025363638040077133 0.13654846433168924 0.3270101533554964 0.017379835479930134 0.04117268981484165 1.347958794504689e-07 6.8703233834629795 0.30612461080345754 GNK(ub)ALSVGNIDDALQCYSEAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNKALSVGNIDDALQCYSEAIK 22 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 43530600.0 30123000.0 8815200.0 4592400.0 True False 25048609.175166152 8767710.76791979 5552649.607141515 1.0 0.3500278481175046 0.22167496679402693 24.57822716416711 -13.99999999999996 0.22805773132141105 5.066544248223978 0.15810412497889112 0.9995072037646433 0.007563345699363738 13.231535167959722 0.1512226802613723 24.33811303854744 0.06744108399729451 1.000000000000094e-14 13.99999999999996 -4.908440123245087 GNK(ub)ALSVGNIDDALQCYSEAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNKALSVGNIDDALQCYSEAIK 22 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 64998600.0 31370000.0 26425000.0 7203600.0 True False 40609083.39514619 24954425.520558123 5892618.715177785 1.0 0.6145035404453577 0.14510592760343125 25.275299128159297 -7.564936174859661 0.4483225481315103 1.0261572938880437 4.806371723330581e-26 0.9978825456660521 0.01608569172443152 0.11888511650902397 0.06411888617701478 0.022447069574345592 0.070576639528756 2.7231014733351724e-08 7.564936174859661 -1.0261572938880437 down GNK(ub)PWISLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNKPWISLPR 10 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 1 27965700.0 1043400.0 2904700.0 24017600.0 True False 1582914.082757667 2386333.590475317 19270510.83271198 1.0 1.5075572429793387 12.174072517656766 20.594151520476263 -6.9168214406920265 0.8479709027753597 0.7366266987537732 13.774361842966323 0.993251393160897 0.4232399612883206 0.10007817252853966 0.1155734456630399 0.3586550275003152 1.0437538035420413 1.2110959708882096e-07 6.9168214406920265 13.03773514421255 up GNK(ub)PWISLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNKPWISLPR 10 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 1 6083700.0 903200.0 2205400.0 2975100.0 True False 1237137.448062238 2107958.135717467 2272442.6541078333 1.0 1.7038997073600988 1.8368554421072791 20.23857436440149 -11.194800147145152 0.30260018378208964 3.5794183574520754e-11 1.8743208057896221 0.9993064604427827 0.009670088059359847 3.2523811014431367 0.15749302072288496 2.2501016582929236 0.04736360825792518 6.385572687265114e-12 11.194800147145152 1.8743208057538279 GNK(ub)PWISLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNKPWISLPR 10 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 1 7234800.0 1401800.0 3028600.0 2804400.0 True False 1165658.8102694904 3012284.3306699693 3390787.073919444 1.0 2.584190420156954 2.9089018536526337 20.15271414108408 -10.189428206346866 0.35994642994187037 1.1386174177244307e-14 2.9663186730899533 0.9989733934611458 0.026719807880273835 1.583935062133747 0.16520349191638192 1.6709646912832752 0.09299109673335158 6.46504859528177e-11 10.189428206346866 2.966318673089942 GNK(ub)PWISLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNKPWISLPR 10 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 1 14349000.0 1043400.0 4039900.0 9265700.0 True False 1350701.8684888596 3815076.013642493 7579437.674110557 1.0 2.824513760324275 5.611480853721105 20.365277842568712 -6.964953377459769 0.35885122080171894 0.7566733759983669 7.774657185580153 0.9999121816612899 0.01777000745728846 0.07797677974149095 0.0149157275100074 0.03747976647710046 0.23820676221496576 1.084043282386238e-07 6.964953377459769 7.017983809581787 GNKPWISLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNKPWISLPR 10 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 14473300.0 2761000.0 6196200.0 5516100.0 False True 3619697.7375620315 5271751.112598432 4945346.886167475 1.0 1.4564064446301268 1.3662320018738099 21.787437799581028 -9.989704240233916 4.596576623591527 0.9999917079522183 1.411319223287217 0.9652070940750165 0.03681356222378374 12672790.776098818 0.47577213501442495 1252.548323796923 0.012602261513810145 1.0239901044611173e-10 9.989704240233916 0.4113275153349987 GNKPWISLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNKPWISLPR 10 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 8583700.0 3041400.0 1516400.0 4025900.0 False True 2944852.4217781876 2121906.4279215336 2971396.0155888554 1.0 0.7205476282034754 1.0090135565417027 21.48976390602726 -10.991547774742207 10.81009725387027 1.1095644529277264 0.8647805923078338 0.22658870396460307 0.11776572210115252 0.06745704458583827 5.274347632875215e-05 0.024735020198656157 0.03800872337098785 1.0196525865749298e-11 10.991547774742207 -0.24478386061989266 GNKPWISLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNKPWISLPR 10 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 13235700.0 2761000.0 6119300.0 4355400.0 False True 3781816.313219481 5848929.092180952 3326744.222278667 1.0 1.5465925914317415 0.8796683780356829 21.85064786110392 -6.688895250287854 1.8699508326704224 1.3430468099840585 0.881987036772698 0.36521469629920245 0.23122547455748835 0.41917253161803253 2.8408195157187084 0.09894292122847971 0.25805073174368376 2.046938288726867e-07 6.688895250287854 -0.4610597732113605 GNKPWISLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNKPWISLPR 10 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 6042800.0 3041400.0 1917500.0 1083900.0 False True 2529058.856865194 1907170.0469060515 1310538.4786126388 1.0 0.7541026740951442 0.5181921626913304 21.270169181461537 -6.971630399864867 0.21572663018328328 1.1148363667342323 0.15082985831932721 0.9999924580856028 0.0005401884909239355 0.07577718282213411 0.0071060908309091165 0.0067535825556474935 0.024132284197362786 1.0675042190295728e-07 6.971630399864867 -0.964006508414905 GNKPWISLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNKPWISLPR 10 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 11747300.0 3478400.0 3300400.0 4968500.0 False True 4502857.369514716 3116729.8387152334 4064283.9811151125 1.0 0.6921671247719603 0.9026010925043203 22.10240934956828 -10.097003317275234 5.073163922252293 1.0000053164693616 0.7973841097153913 0.5527930647288262 0.08590930758416551 5.165971179427738e-06 9.196857699576166e-07 0.083183510623581 0.027727109796200924 7.99828145649569e-11 10.097003317275234 -0.20262120675397033 GNLANVIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNLANVIR 8 0 P05141;Q9H0C2;P12236;V9GYG0;P12235 P05141;P12236 SLC25A5;SLC25A31;SLC25A6;SLC25A4 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed;ADP/ATP translocase 4;ADP/ATP translocase 4, N-terminally processed;ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed;ADP/ATP translocase 1 0 4991720.0 1766800.0 367820.0 2857100.0 False True 1710713.9010974232 514692.4441559599 2108739.798837256 1.0 0.3008641268570885 1.2326665478573007 20.70616707375678 -6.705895860507042 1.8096255581911553 0.5684057698309086 1.2302446194084398 0.4457112059020243 0.2948071886065756 0.3833729551303664 2.4445831274827263 0.12976494648152187 0.3313408896544558 1.9683582258275244e-07 6.705895860507042 0.6618388495775311 GNLEEAK(ub)QLYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNLEEAKQLYK 11 1 G5E9G4;Q9ULT0;Q9ULT0-4 G5E9G4 TTC7A Tetratricopeptide repeat protein 7A 1 12171100.0 2540100.0 4263100.0 5367900.0 True False 3853517.406184354 3502316.497247674 4306932.212165847 1.0 0.9088622492341538 1.1176625815297543 21.87774447689471 -6.788112638124299 1.5042938810902091 0.9489372547946147 1.1197560479338542 0.7950116291840577 0.038697697629246346 0.23818195490374708 1.0648729856154533 0.020252492825271248 0.047473364903876374 1.6288735150626672e-07 6.788112638124299 0.17081879313923953 GNLEEAK(ub)QLYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNLEEAKQLYK 11 1 G5E9G4;Q9ULT0;Q9ULT0-4 G5E9G4 TTC7A Tetratricopeptide repeat protein 7A 1 11397000.0 2540100.0 2705500.0 6151400.0 True False 3288209.522856581 2554936.5466743596 5031908.318694077 1.0 0.7769993149508302 1.5302882263788 21.648870798987158 -6.8273984735445 1.3394032002091134 0.8806076084848353 1.5495142019441444 0.900578550663276 0.09962047490059017 0.18405105612260167 0.64665617935194 0.058411000169580805 0.13444922336507176 1.4879951869729084e-07 6.8273984735445 0.668906593459309 GNLGAGNGNLQGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNLGAGNGNLQGPR 14 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6R991;D6RIA2;D6RE02;D6RBI2;D6RAY2;D6RAM9 P43243 MATR3 Matrin-3 0 5980500.0 1619800.0 0.0 4360700.0 False True 1568380.3356336942 0.0 3218501.8518041475 1.0 0.0 2.052118213088748 20.580844027881724 -6.774204809410059 1.5583755865316886 0.42950561916767005 2.0655331477854357 0.7463585345557993 0.4219719275626548 0.2596941424899772 1.2451952155635964 0.2133617484420878 0.5059526073330493 1.6818807140507065e-07 6.774204809410059 1.6360275286177657 GNLLQCICTGNGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNLLQCICTGNGR 13 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 17110500.0 3134200.0 7524600.0 6451700.0 False True 4108966.551635971 6401959.010661072 5784139.9730764 1.0 1.5580460269534573 1.4076872859365246 21.97034415585668 -10.057869588182426 4.778052401510973 0.9999855985463435 1.4828666563735133 0.9322082075007332 0.06138369900724334 42550125.06736014 0.08601884372499095 7122.652302501333 0.021013272876206423 8.752465585769848e-11 10.057869588182426 0.48288105782716984 GNLLQCICTGNGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNLLQCICTGNGR 13 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 15916200.0 3134200.0 7321300.0 5460700.0 False True 4292998.438570262 6997820.757698492 4170995.126646718 1.0 1.6300543449601261 0.9715808627304845 22.03355421737957 -6.656135249201843 1.9862614987579856 1.4068262538461285 0.9743172637634662 0.21950527658696228 0.2685092150862049 0.49363147927183 3.7394517025452565 0.10936476705310498 0.29760950182201024 2.2073172170709806e-07 6.656135249201843 -0.4325089900826623 GNLYSFGCPEYGQLGHNSDGK(ub)FIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNLYSFGCPEYGQLGHNSDGKFIAR 25 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 14310000.0 4790000.0 6365400.0 3154600.0 True False 6279736.386425988 5415707.132134867 2828192.2530599376 1.0 0.8624099482649032 0.4503679898368406 22.582272567616503 -6.951491074459689 0.5422355538687248 1.0059787191955327 0.2876983625523333 0.9993131087889022 0.006120360400641458 0.08289263455548473 0.033527940623960285 0.006711222608670821 0.03413526249872298 1.1181728048298917e-07 6.951491074459689 -0.7182803566431994 down GNLYSFGCPEYGQLGHNSDGK(ub)FIAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNLYSFGCPEYGQLGHNSDGKFIAR 25 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 62679600.0 13064000.0 9104600.0 40511000.0 True False 19819043.106331404 7479812.995435512 32503983.093397956 1.0 0.37740535480474363 1.6400379634380136 24.24038397289758 -6.772646891603107 1.564531319439281 0.6441036594649087 1.6478273556541332 0.7405141024211481 0.262586303796381 0.26216738344251383 1.266846136058037 0.1322705072712367 0.31407346417073084 1.6879248554013786e-07 6.772646891603107 1.0037236961892244 GNLYSFGCPEYGQLGHNSDGK(ub)FIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNLYSFGCPEYGQLGHNSDGKFIAR 25 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 17669700.0 4790000.0 7801700.0 5078000.0 True False 6560992.444882773 7456995.097228144 3878680.9846928115 1.0 1.1365651096038383 0.5911729082568868 22.645482629139394 -6.8403857833579105 1.2805898752826166 1.072645999506445 0.5730955282697549 0.9251192154470927 0.06340834179555814 0.16834697210393795 0.536107822176461 0.03882362508662595 0.08945215056826517 1.4441563581413976e-07 6.8403857833579105 -0.49955047123669016 GNLYSFGCPEYGQLGHNSDGK(ub)FIAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNLYSFGCPEYGQLGHNSDGKFIAR 25 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 70584800.0 13064000.0 5903800.0 51617000.0 True False 16911605.529939126 5575248.340142706 42223235.63514513 1.0 0.32966996127438497 2.4967017803481792 24.01151029499003 -6.823652137584893 1.3562047177618095 0.6399825314184668 2.547736673691264 0.8925342944301005 0.29696359828424274 0.18878046768379983 0.68128455773839 0.17203266246937124 0.3961338338321908 1.5008865384856547e-07 6.823652137584893 1.9077541422727973 up GNNVK(ub)TFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNNVKTFLK 9 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 35834500.0 12264000.0 17341000.0 6229500.0 True False 16078222.76474494 14753790.394688586 5584931.097583498 1.0 0.9176256984720684 0.3473599774864231 23.938604608651737 -6.932888916248306 0.7226895416755988 1.0078110989162707 0.22118372177727552 0.9970761022661809 0.015691831740811037 0.09116545610283751 0.07053447288031622 0.014550031071010433 0.05080450605445633 1.1671081015521531e-07 6.932888916248306 -0.7866273771389952 down GNNVK(ub)TFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNNVKTFLK 9 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 36349000.0 10219000.0 11446000.0 14684000.0 True False 9894603.438597802 16016447.490101455 10837819.88944254 1.0 1.6187053467573027 1.0953263520562482 23.238210456623943 -10.142147385802067 4.5219305119757705 0.999955674108124 1.3570158491781377 0.3828735214129553 0.21366857988764032 149352456.17389068 6.447389845841716 73330.91238438372 0.07314443814112771 7.20862799647563e-11 10.142147385802067 0.35706017507001364 GNNVK(ub)TFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNNVKTFLK 9 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 77389000.0 27300000.0 16052000.0 34037000.0 True False 41416095.89733977 13187395.185151555 27309572.031052954 1.0 0.31841232012403675 0.6593951322390843 25.30368822803046 -10.611855447908775 6.624317398424529 1.0013718606691888 0.48890372618201605 0.7497226955357419 0.13920565012352876 0.0028267241509354656 0.00016562864675866615 0.13508777937503824 0.044928430385533596 2.444243968010205e-11 10.611855447908775 -0.5124681344871728 GNNVK(ub)TFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNNVKTFLK 9 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 29096800.0 12264000.0 9585900.0 7246900.0 True False 16798332.22213826 9162363.241667751 5535331.474590453 1.0 0.5454329108691407 0.3295167282913673 24.001814670174628 -11.235180082235225 0.1366239939551015 2.0761275204925176 2.1906081656599877e-15 0.9997154314949671 0.004713975902973618 3.6984483264578296 0.08365691915912465 1.4515355502049159 0.23160329242348013 5.818618959890618e-12 11.235180082235225 -2.0761275204925154 GNNVK(ub)TFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNNVKTFLK 9 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 43178000.0 10219000.0 21248000.0 11711000.0 True False 8497551.278459085 21133532.80660223 14159715.954453934 1.0 2.4870144485241052 1.6663289800142995 23.01861573205822 -10.076303398393936 5.297921498293421 0.9999862465637148 2.076671714270458 0.6964948557053909 0.33504343953205734 5.442833424670018e-05 9.490465791888647e-06 0.32440854877553005 0.10813480512967495 8.388737440516108e-11 10.076303398393936 1.0766854677067432 GNNVK(ub)TFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNNVKTFLK 9 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 68737000.0 27300000.0 18469000.0 22968000.0 True False 35340388.16345206 17441183.91444419 18788059.671581358 1.0 0.4935198740256431 0.531631389691735 25.07481455012291 -9.979426104505789 6.090228025525001 1.000000296742183 0.5125756331188727 0.9954357175743078 0.01555896111784403 6.269288719772382e-08 1.0523481212551874e-08 0.015064908414704405 0.0050216331077825305 1.0485131836177658e-10 9.979426104505789 -0.4874246636233104 GNNVLYISTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNNVLYISTQK 11 0 P62312 P62312 LSM6 U6 snRNA-associated Sm-like protein LSm6 0 50622000.0 11764000.0 16584000.0 22274000.0 False True 15422717.92273804 14109731.843925688 19969300.147295095 1.0 0.914866751412435 1.2947977293842567 23.878553695880022 -6.8478697005529385 1.2452999414779546 0.9546395229727715 1.3093755821993838 0.937154909247447 0.040809328503369435 0.15981249587470067 0.4779835648031563 0.025656454523531987 0.05929637443980761 1.4194833390978542e-07 6.8478697005529385 0.3547360592266122 GNNVLYISTQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNNVLYISTQK 11 0 P62312 P62312 LSM6 U6 snRNA-associated Sm-like protein LSm6 0 31464000.0 8771900.0 4378100.0 18314000.0 False True 8493440.835995292 6126298.161489883 13517013.99177683 1.0 0.7212975612341428 1.5914650202179053 23.017917701591944 -6.8205164819874 1.369544295699583 0.8498568868990753 1.6106881596144647 0.8855886090975696 0.12272049028498 0.1928093927101611 0.7104537441195058 0.07041133105577241 0.16227232098447428 1.5117623251102792e-07 6.8205164819874 0.7608312727153893 GNNVLYISTQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNNVLYISTQK 11 0 P62312 P62312 LSM6 U6 snRNA-associated Sm-like protein LSm6 0 30442800.0 6980500.0 17167000.0 6295300.0 False True 10589928.8429077 14103414.723616807 5051031.195671985 1.0 1.3317761557068593 0.47696554628455007 23.336189559648577 -6.801454782118603 1.449879181792785 1.1827234338822807 0.46472722212957607 0.8363890193707394 0.14232924562762003 0.2186983346482941 0.9074628225428819 0.0772196979575684 0.17943473436876928 1.579593063278602e-07 6.801454782118603 -0.7179962117527047 down GNNVLYISTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNNVLYISTQK 11 0 P62312 P62312 LSM6 U6 snRNA-associated Sm-like protein LSm6 0 38399000.0 11764000.0 9512000.0 17123000.0 False True 16113468.71014631 9091728.388022369 13078900.059254618 1.0 0.5642316096904386 0.8116750213452869 23.941763757402914 -10.169730283122133 5.44352212855586 1.0000094325256756 0.6879533155178069 0.6795324249059764 0.10101834979483462 1.1564344638506005e-05 1.7637618496582112e-06 0.09781355252172952 0.03260353220136732 6.765029844706328e-11 10.169730283122133 -0.3120561170078687 GNNVLYISTQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNNVLYISTQK 11 0 P62312 P62312 LSM6 U6 snRNA-associated Sm-like protein LSm6 0 23178200.0 8771900.0 9459100.0 4947200.0 False True 7294223.511059312 9408141.950815644 5981636.646731667 1.0 1.289807192849419 0.8200511867592849 22.79832297702622 -6.7398084246051475 1.6873470884600268 1.1724737022897564 0.8197854423284001 0.6040788213693082 0.12176547026325447 0.31817584458467363 1.7786422223010478 0.057089758392681406 0.14012535125891898 1.820503739663058e-07 6.7398084246051475 -0.35268825996135633 GNPGFSGLNLNIPILSSLGSSAPSESHPSDFQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNPGFSGLNLNIPILSSLGSSAPSESHPSDFQR 33 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 0 33557400.0 9461600.0 14968000.0 9127800.0 False True 14353938.935614288 12296843.454482216 7323686.329143139 1.0 0.8566877363517197 0.5102213658560277 23.774943352547982 -6.9561760975338744 0.48633878336423947 1.0078398642255786 0.34446835202837844 0.9996010427203619 0.0041067312055802305 0.08109643604169255 0.026401622779863517 0.004949603948395871 0.028576197824800764 1.1061751616163685e-07 6.9561760975338744 -0.6633715121972001 GNPK(ub)LNLAFIANLFNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNPKLNLAFIANLFNR 16 1 P13796 P13796 LCP1 Plastin-2 1 21830600.0 7958600.0 8686400.0 5185600.0 True False 12073778.051595917 7136244.05284703 4160663.8870707774 1.0 0.5910531088405885 0.3446033105205888 23.525373850116605 -8.8217521054153 0.17225996663932694 1.4209528891156902 3.892762565931595e-12 0.9997787296020384 0.004020632707914371 0.33777777476712717 0.05140394993290797 0.22513368162662062 0.14953060783162192 1.5074672805335551e-09 8.8217521054153 -1.4209528891117975 down GNPK(ub)LNLAFIANLFNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNPKLNLAFIANLFNR 16 1 P13796 P13796 LCP1 Plastin-2 1 21847600.0 7958600.0 7009300.0 6879700.0 True False 10302564.587459696 6619226.293330101 5627665.191683132 1.0 0.6424833581132835 0.5462392537226254 23.296500172209054 -13.999999999999998 0.18417782511086125 2.879545755669223 0.47299684007366366 0.9994936898804581 0.004392593388979848 12.261689373651238 0.13607703181666747 8.256048251921351 0.06938713874399945 1.0000000000000041e-14 13.999999999999998 -2.4065489155955593 GNPTVEVDLFTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNPTVEVDLFTSK 13 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5 P06733 ENO1 Alpha-enolase;Enolase 0 522390000.0 158140000.0 226210000.0 138040000.0 False True 207323071.4299386 192460349.75967363 123756944.97318003 1.0 0.9283112990379964 0.5969279932021537 27.627305431192482 -6.941571002614898 0.6447891445185553 1.0036423170276099 0.5032792074599541 0.9983624319952948 0.0071047385937447315 0.08705737283299839 0.051401672935303594 0.007001167596998925 0.028329961867401894 1.1440078311871892e-07 6.941571002614898 -0.5003631095676557 GNPTVEVDLFTSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNPTVEVDLFTSK 13 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5 P06733 ENO1 Alpha-enolase;Enolase 0 693730000.0 216680000.0 161650000.0 315400000.0 False True 209801612.00463524 226197687.99361378 232787278.20281777 1.0 1.0781503813641635 1.1095590542825509 27.644450521962405 -13.999999999996305 0.1256368149971735 0.6285327684027863 1.1560830984032737 0.999665776282379 0.0008421156115505982 11.945416373881557 0.10976926892247675 1.1004831868139588 0.041319267561844814 1.0000000000085077e-14 13.999999999996305 0.5275503300004875 GNPTVEVDLFTSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNPTVEVDLFTSK 13 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5 P06733 ENO1 Alpha-enolase;Enolase 0 1818170000.0 288210000.0 987720000.0 542240000.0 False True 437235640.9733444 811453648.9084165 435066026.32776546 1.0 1.855872607050087 0.9950378824545294 28.703835765231645 -10.485044095323724 3.9306306019006696 0.9959751245636739 1.4254552447613997 0.24567691237880462 0.3514343047179947 253954668.67204702 44149.5749012346 9250750.865630098 0.12030526108699306 3.2730746060633454e-11 10.485044095323724 0.42948012019772586 GNPTVEVDLFTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNPTVEVDLFTSK 13 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5 P06733 ENO1 Alpha-enolase;Enolase 0 611380000.0 158140000.0 210920000.0 242320000.0 False True 216608631.57281044 201600856.98083222 185089006.7370543 1.0 0.9307147896969492 0.8544858318577152 27.690515492715374 -6.969897118365063 0.26063130299703235 1.0212370593385613 0.7617000972238338 0.9999815599432962 0.0002551316690098918 0.07633608920392687 0.00914950298152209 0.001584833075658393 0.0071855332497314595 1.0717731714992235e-07 6.969897118365063 -0.25953696211472754 GNPTVEVDLFTSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNPTVEVDLFTSK 13 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5 P06733 ENO1 Alpha-enolase;Enolase 0 511710000.0 216680000.0 143760000.0 151270000.0 False True 180179020.5515717 142985536.34587413 182899857.606545 1.0 0.7935748341186488 1.0151007428425582 27.42485579739668 -11.122064031032169 11.569806654294702 3.471710799732416 0.9043377884806035 0.199128474814245 0.09043757352998978 0.03746975930600052 0.0003953150793797757 0.0005690394243800926 0.029188601346088278 7.549809074146094e-12 11.122064031032169 -2.5673730112518127 GNPTVEVDLFTSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNPTVEVDLFTSK 13 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5 P06733 ENO1 Alpha-enolase;Enolase 0 1234141700.0 288210000.0 577120000.0 368811700.0 False True 373093526.4684441 545002764.6707474 301691754.9276102 1.0 1.4607671428382267 0.8086223253008573 28.474962087324094 -6.716880434298157 1.7705366993202551 1.2812542024404283 0.8098120958962275 0.49776372340260155 0.19397023577378233 0.3614111624324163 2.2124201985884904 0.08704601211120523 0.2193242034766467 1.919197042470292e-07 6.716880434298157 -0.4714421065442008 GNPTVEVDLFTSK(ub)GLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNPTVEVDLFTSKGLFR 17 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5 P06733 ENO1 Alpha-enolase;Enolase 1 17039700.0 4359400.0 5368200.0 7312100.0 True False 4221013.233214918 7511750.25479318 5396841.651702039 1.0 1.7796083167149623 1.2785654423527018 22.00915792159149 -10.424051555639464 6.620111450930292 0.9999185983457278 1.5290868795337362 0.5978714679828674 0.20454989690749303 0.0002458196873387554 2.13862062377162e-05 0.1980847552175098 0.06601819534926363 3.766590826604414e-11 10.424051555639464 0.5291682811880084 GNPTVEVDLFTSK(ub)GLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNPTVEVDLFTSKGLFR 17 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5 P06733 ENO1 Alpha-enolase;Enolase 1 61577400.0 19807400.0 13924000.0 27846000.0 True False 30049273.91490727 11439153.411291454 22342225.894664653 1.0 0.38067986080743726 0.7435196590084929 24.84082679551345 -10.406759521328684 5.859529204998479 1.0001463070564869 0.5620997599080485 0.6601003621191606 0.1481287273278354 0.000283212390529404 2.8673670666843274e-05 0.14347237820467 0.047808341169633624 3.919588535067993e-11 10.406759521328684 -0.4380465471484384 GNPTVEVDLFTSK(ub)GLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNPTVEVDLFTSKGLFR 17 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5 P06733 ENO1 Alpha-enolase;Enolase 1 14154800.0 4359400.0 4456400.0 5339000.0 True False 3625034.254165234 4432392.4886738565 6455360.215253143 1.0 1.222717408416473 1.7807721976242872 21.789563197025767 -6.955413283953714 0.49587063706918477 0.9884125638548416 2.038977970941789 0.9995604536780044 0.00688507280923097 0.08138216957901781 0.027509714858636437 0.00813852679391437 0.046029353752832604 1.1081198027590021e-07 6.955413283953714 1.0505654070869472 GNPTVEVDLFTSK(ub)GLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNPTVEVDLFTSKGLFR 17 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y798;A0A2R8YEG5 P06733 ENO1 Alpha-enolase;Enolase 1 58766400.0 19807400.0 12846000.0 26113000.0 True False 25641069.762225673 12131108.807458442 21360701.942006443 1.0 0.47311242939364195 0.8330659422593573 24.6119531176059 -10.110985809716782 5.662206262019501 1.0000032094907103 0.6530891858264603 0.5532640675989338 0.14695040627404826 5.9538064846801555e-06 9.350125448813201e-07 0.14228543545107483 0.047428039684793956 7.744871032398544e-11 10.110985809716782 -0.34691402366425006 GNQLCSLISGIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNQLCSLISGIIR 13 0 Q53GS7;Q53GS7-2 Q53GS7 GLE1 Nucleoporin GLE1 0 6630390.0 496090.0 3244700.0 2889600.0 False True 679507.8793281612 3101338.425211957 2207135.9931800608 1.0 4.564094868595627 3.2481389257211943 19.374130754497553 -9.649627111890824 7.953781493053668 1.0000000212577247 3.9061169970590455 0.8667115845447636 0.5372367640043445 3.213075638921048e-09 5.0618016806487555e-18 0.5201772677410109 0.1733924199965886 2.2406441447516917e-10 9.649627111890824 2.9061169758013206 GNRPVILTYHDIGMNHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNRPVILTYHDIGMNHK 17 1 Q92597;E5RIR1;E5RGM5;E5RIV1;E5RIM2;E5RI76;E5RH82;E5RK17 Q92597 NDRG1 Protein NDRG1 0 36284000.0 14901000.0 10404000.0 10979000.0 False True 19535355.301489253 8851763.75447437 9842998.398004523 1.0 0.45311506332314144 0.5038556118431158 24.219584159151353 -10.42642945183782 9.303910643339613 1.0000024033522903 0.4784853384738311 0.9929503734703503 0.02071474219047823 1.0326750572767933e-06 6.366890819825482e-08 0.020057055179491138 0.006685654293725197 3.746023936854515e-11 10.42642945183782 -0.5215170648784592 GNRPVILTYHDIGMNHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNRPVILTYHDIGMNHK 17 1 Q92597;E5RIR1;E5RGM5;E5RIV1;E5RIM2;E5RI76;E5RH82;E5RK17 Q92597 NDRG1 Protein NDRG1 0 32072200.0 14901000.0 9869800.0 7301400.0 False True 20410302.38438373 9433719.600935983 5576959.69705319 1.0 0.4622038137050768 0.2732423847537025 24.282794220674244 -13.999999999999998 0.14578529953269043 3.585081984594884 0.05492505424570152 0.9995809102178436 0.006302807649400289 11.944372155196483 0.12001585957491391 8.759523894018882 0.19602993667789712 1.0000000000000041e-14 13.999999999999998 -3.5301569303491824 GNSIIMLEALER ddPTM_RPMI8226_Bortezomib_1h_R1 2 GNSIIMLEALER 12 0 P62308;A8MWD9;Q49AN9;F5H013 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 0 63611400.0 15482700.0 23002600.0 25126100.0 False True 20297969.634680096 19570701.743432514 22526292.19857015 1.0 0.9641704119014441 1.1097805644601446 24.274832088938528 -6.841614297723681 1.2747750286440174 0.9809406285890403 1.1147277285554316 0.9272021768151377 0.01671419852680252 0.1669288981297906 0.5262255509553008 0.010277858403636096 0.023690789375131818 1.4400769605768872e-07 6.841614297723681 0.13378709996639127 GNSIIMLEALER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNSIIMLEALER 12 0 P62308;A8MWD9;Q49AN9;F5H013 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 0 59284500.0 25396000.0 9509500.0 24379000.0 False True 24589817.88106757 13306692.941387383 17993408.545676924 1.0 0.5411464617488119 0.7317422452132345 24.551557714190118 -10.204991645097767 5.443153500161645 1.0000171087541094 0.6364443534809813 0.8290964414931132 0.07781040276911887 1.6155775830489157e-05 2.359715855792533e-06 0.07534314041965141 0.025113199507186008 6.237468349296007e-11 10.204991645097767 -0.36357275527312816 GNSIIMLEALER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNSIIMLEALER 12 0 P62308;A8MWD9;Q49AN9;F5H013 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 0 58802300.0 5850300.0 42220000.0 10732000.0 False True 8875332.814220035 34685511.133634366 8610815.495997291 1.0 3.908080052847295 0.9701963493922239 23.081369789158114 -6.648478915215126 2.013738806750399 2.8892676746909904 0.9824587327000106 0.1880536224744308 1.2416536551360762 0.5122195343316968 3.9795424123697187 0.5003350368146627 1.375392069804083 2.2465758435036472e-07 6.648478915215126 -1.9068089419909797 GNSIIMLEALER ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GNSIIMLEALER 12 0 P62308;A8MWD9;Q49AN9;F5H013 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 0 68052700.0 15482700.0 29531900.0 23038100.0 False True 21207072.59423518 28227083.009066198 17596975.264563087 1.0 1.3310221334716088 0.8297691813129624 24.33804215046142 -6.728606309410733 1.7280275368699956 1.1995208877910537 0.8301298070964701 0.5528133174966895 0.13917106265182483 0.338910315664052 1.9819260045477969 0.06383531414190269 0.158670745743538 1.8680723424595022e-07 6.728606309410733 -0.3693910806945836 GNSIIMLEALER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNSIIMLEALER 12 0 P62308;A8MWD9;Q49AN9;F5H013 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 0 40726900.0 25396000.0 6839300.0 8491600.0 False True 21117899.233559713 6802455.333405248 10267154.299277686 1.0 0.3221179937536145 0.48618255943571975 24.331962989624394 -10.441208197282862 9.139158003728683 1.0000046585436035 0.40415027659784436 0.9461978857816529 0.06697907846541563 6.357711125922542e-06 3.88705804932635e-07 0.06485272058242392 0.021617404620072878 3.620693836538064e-11 10.441208197282862 -0.5958543819457591 GNSIIMLEALER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNSIIMLEALER 12 0 P62308;A8MWD9;Q49AN9;F5H013 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 0 29209200.0 5850300.0 13816000.0 9542900.0 False True 7573328.676653614 13047127.454759913 7806190.118422738 1.0 1.722773170400017 1.030747568435392 22.852496111250563 -10.360195017893748 5.101999001622768 0.9997949872677054 1.3767603694177446 0.28326057618035605 0.2825182689594237 0.000659179033285761 8.266261995384874e-05 0.2736943785289742 0.09118237922324628 4.363198608628062e-11 10.360195017893748 0.37696538215003916 GNSIIMLEALERV ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNSIIMLEALERV 13 1 P62308;A8MWD9;Q49AN9;F5H013 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 0 5942800.0 1999900.0 1333000.0 2609900.0 False True 1936414.2691899128 1865273.8515031696 1926288.8946782951 1.0 0.9632617778031018 0.9947710700790005 20.884956199710604 -10.353854380349096 5.450705368438713 1.000006308554281 0.979016423941052 0.37158969245203155 0.01286361470536308 9.864581429585016e-07 1.1694663000355439e-07 0.012458885939370909 0.004151713793824823 4.427367978508459e-11 10.353854380349096 -0.020989884613228926 GNSIIMLEALERV ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNSIIMLEALERV 13 1 P62308;A8MWD9;Q49AN9;F5H013 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 0 30434800.0 0.0 22918000.0 7516800.0 False True 0.0 18828103.840848695 6031101.185269517 0.0 GNSIIMLEALERV ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNSIIMLEALERV 13 1 P62308;A8MWD9;Q49AN9;F5H013 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 0 10606000.0 0.0 5525400.0 5080600.0 False True 0.0 5217906.632783043 4155982.9313582466 0.0 GNSIK(ub)ESIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNSIKESIR 9 1 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07;Q13098-6;J3KSA5;J3KRJ4;J3QLT0 Q13098-7 GPS1 COP9 signalosome complex subunit 1 1 3045200.0 629920.0 864480.0 1550800.0 True False 609923.5344007746 1209671.3722036434 1144598.9569972414 1.0 1.9833164388255602 1.8766269744317439 19.218268858988306 -10.551719016592855 6.041279547001004 0.9981791297536272 1.9299717066286521 0.990225401400216 0.04355579144928088 0.0010696092897151 7.936812682562874e-05 0.042228054943283334 0.014057571242828982 2.8072493077195785e-11 10.551719016592855 0.9317925768750249 GNSIK(ub)ESIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNSIKESIR 9 1 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07;Q13098-6;J3KSA5;J3KRJ4;J3QLT0 Q13098-7 GPS1 COP9 signalosome complex subunit 1 1 4149020.0 629920.0 2089200.0 1429900.0 True False 523806.39018758567 2077945.064926266 1728885.4788893906 1.0 3.9670097651579086 3.300619296130087 18.998674134422583 -10.568711655515257 7.253105783002333 0.9980393268432355 3.6338145306439977 0.9541876842086844 0.2720527697620201 0.008622642925230009 0.000512724836293424 0.2633267132051008 0.08780465388149208 2.699531158123161e-11 10.568711655515257 2.6357752038007622 GNSPPSSGEACR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNSPPSSGEACR 12 0 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 0 2458780.0 984470.0 450010.0 1024300.0 False True 953218.5387216321 629701.3397711478 756005.1016586752 1.0 0.6606054269733829 0.7931078456285154 19.86244748456936 -10.184747158582415 6.2330117277245245 1.0000022641721313 0.7268566363009484 0.8499837819605027 0.05409388589828761 1.7019995329131025e-06 2.2263576918316533e-07 0.05237661368952476 0.01745872660130896 6.535109087005631e-11 10.184747158582415 -0.2731456278711829 GNTAAYLLYAFTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNTAAYLLYAFTR 13 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 25393400.0 6111400.0 10490000.0 8792000.0 False True 8012104.582881788 8924932.889699738 7882288.1788191805 1.0 1.113931152217889 0.983797465107986 22.933749822254647 -6.675431193733933 1.9185343768122003 1.0723799682296589 0.9843134149997661 0.3032204740388288 0.04833579072423377 0.44871755204149827 3.1892565249367886 0.02024792054581801 0.053709013820396015 2.1113916819146716e-07 6.675431193733933 -0.08806655322989276 GNTAAYLLYAFTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNTAAYLLYAFTR 13 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 23028800.0 8509000.0 4906500.0 9613300.0 False True 8238886.452591122 6865691.037059492 7095288.337181834 1.0 0.8333275469405503 0.8611950629505729 22.97401792883393 -10.850752556858971 10.638175116513096 1.0039466502365442 0.8472613049512502 0.9756415291900786 0.011376865770566048 0.001082366437930974 1.5184951248267248e-05 0.011195978007457703 0.003671867638453286 1.4100919820291598e-11 10.850752556858971 -0.156685345285294 GNTAAYLLYAFTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNTAAYLLYAFTR 13 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 27028400.0 6747200.0 6636200.0 13645000.0 False True 10235995.686393093 5451918.261132745 10948059.769184044 1.0 0.532622172592363 1.0695647111045103 23.287148108727656 -6.676581778647353 1.9137491722010895 0.7033884183338984 1.0674842973380902 0.3086786536417362 0.19823445727354616 0.4461595486076005 3.1561080193181206 0.08320314048480638 0.2204312017154209 2.105805333679612e-07 6.676581778647353 0.3640958790041918 GNTAAYLLYAFTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNTAAYLLYAFTR 13 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 34537300.0 6111400.0 8186900.0 20239000.0 False True 8370949.734375064 7825175.687542081 15458965.035289034 1.0 0.9348014186978357 1.8467396801831504 22.99695988377754 -6.889728276153337 1.0240272689842242 0.9506805244487949 1.9247473442646919 0.980722413834085 0.057672644986487956 0.11936235930684509 0.22315669558510148 0.0429290367540337 0.10691476280401478 1.2890558194858613e-07 6.889728276153337 0.9740668198158969 GNTAAYLLYAFTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNTAAYLLYAFTR 13 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 18549200.0 8509000.0 4403100.0 5637100.0 False True 7075610.512614575 4379379.626353083 6815791.546994472 1.0 0.6189401774653107 0.9632796399467026 22.754423204268207 -10.341430059833312 8.209012071845049 1.0000008198025234 0.7911099087060066 0.32916646615307954 0.14057599689727376 2.109063068168039e-06 1.692466207525651e-07 0.13611265710793874 0.04537070790497056 4.555855492062544e-11 10.341430059833312 -0.2088909110965168 GNTAAYLLYAFTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNTAAYLLYAFTR 13 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 26784000.0 6747200.0 11117000.0 8919800.0 False True 8734383.407195758 10498329.177371599 7296487.9248768315 1.0 1.20195424083658 0.8353752731836426 23.058274430820106 -6.757145543765575 1.6232212893786349 1.1177228293127461 0.8342224424750043 0.6791890013471946 0.08491136804907799 0.287747624986015 1.4936037288943849 0.041286661084241054 0.0994997650561961 1.7492603661713903e-07 6.757145543765575 -0.2835003868377418 GNTDNK(ub)EYAVNEVVAGIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNTDNKEYAVNEVVAGIK 18 1 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;H0YLJ3;Q9UBU8-3;H0YM21 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 1 181239100.0 143470000.0 27880000.0 9889100.0 True False 217654479.06195417 22904596.172565743 7934515.050453496 1.0 0.10523374603306956 0.036454637114060856 27.697464468422872 -13.631689428158628 0.3674421368389498 9.9988598681628 0.02893095452603168 0.9997765229040393 0.006561289278999164 17.078661956861236 0.195914349284516 119.54984896455147 0.019385538056208095 2.3351273571591832e-14 13.631689428158628 -9.969928913636767 GNTLLNITEHILER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNTLLNITEHILER 14 0 Q9BX82-2 Q9BX82-2 0 50541000.0 10676000.0 17777000.0 22088000.0 False True 16196272.520146498 14604555.457665052 17722297.118485674 1.0 0.9017232477101436 1.0942207286547543 23.94915848747785 -6.767896373333962 1.5822948472168632 0.9434812479271254 1.0952241510804461 0.722553042108875 0.0413972544770158 0.26983067706673597 1.3328888070068667 0.020625335072877858 0.04919643048981508 1.7064895245563874e-07 6.767896373333962 0.15174290315332073 GNTLLNITEHILER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNTLLNITEHILER 14 0 Q9BX82-2 Q9BX82-2 0 28009400.0 10676000.0 9443700.0 7889700.0 False True 13820292.455421764 8918149.793320533 6453855.555158276 1.0 0.6452938548215672 0.4669840074640677 23.7202848095703 -13.999999999995785 0.08902768267924165 2.8240830844616815 0.01322905743854489 0.9998469472307642 0.0027407560740294367 12.172502902304476 0.0864541909405727 4.216365786434591 0.4080528954715207 1.0000000000097061e-14 13.999999999995785 -2.8108540270231366 GNTQTSK(ub)VSSLQAEPLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNTQTSKVSSLQAEPLPR 18 1 Q9H2M9 Q9H2M9 RAB3GAP2 Rab3 GTPase-activating protein non-catalytic subunit 1 19852900.0 3299900.0 0.0 16553000.0 True False 5006189.555004818 0.0 13281292.294562383 1.0 0.0 2.652974312825356 22.25528148777511 -6.804598599031476 1.4372014648350058 0.45144014806016297 2.693835507959659 0.845240627518419 0.430355253662361 0.214253600495453 0.8731825463039288 0.23552545210916687 0.5462504524020083 1.5681998246840166e-07 6.804598599031476 2.242395359899496 GNTQTSK(ub)VSSLQAEPLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNTQTSKVSSLQAEPLPR 18 1 Q9H2M9 Q9H2M9 RAB3GAP2 Rab3 GTPase-activating protein non-catalytic subunit 1 17738300.0 3299900.0 5084300.0 9354100.0 True False 4271785.600753681 4801354.23554111 7651749.7811711505 1.0 1.1239689170481768 1.791229826661042 22.02640780986756 -6.938175590631956 0.6763277140315008 0.9922212520738014 1.9619029979052411 0.9979149896162748 0.015866373749193082 0.0886089362265239 0.05847530790879062 0.015239022685880017 0.057906637128953095 1.1529869966628088e-07 6.938175590631956 0.9696817458314397 GNTSGSHIVNHLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNTSGSHIVNHLVR 14 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 3159540.0 365040.0 1226300.0 1568200.0 False True 478570.975052388 1043340.8200799616 1405937.7072366045 1.0 2.180117212427581 2.937783067773176 18.868373375663886 -8.417389716800649 0.18295494194157425 2.492276387045361e-12 3.9817981204100255 0.999799237740398 0.011297534783053023 0.12632365037565238 0.04457756962033943 0.43314052623279925 0.39272558539489905 3.824813672881644e-09 8.417389716800649 3.9817981204075332 GNTSGSHIVNHLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNTSGSHIVNHLVR 14 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 3464640.0 365040.0 1623400.0 1476200.0 False True 500005.1528350737 1551672.8201340938 1127551.963293329 1.0 3.1033136585412584 2.255080686468948 18.931583437186777 -10.499188243412066 6.1039399770619704 0.9985270922567795 2.6791971725050643 0.8393653559411336 0.34628966076360285 0.006944194498005585 0.0005697512517196078 0.3354429161036536 0.11176450742510412 3.1681939229005885e-11 10.499188243412066 1.6806700802482848 GNVAGDSK(ub)NDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACK 49 1 P68104;A0A087WVQ9;A0A087WV01 P68104 EEF1A1 Elongation factor 1-alpha 1;Elongation factor 1-alpha 1 212042000.0 18819000.0 61069000.0 132154000.0 True False 28549798.85318822 50170759.81572517 106033703.97484413 1.0 1.7573069454435923 3.713991279591909 24.766977245367777 -6.954752176966952 0.5039865129938615 0.9621317877486367 4.59413337176615 0.9995233450785025 0.024964899223493146 0.08163188145892313 0.028486179712995434 0.029062468650646916 0.16143455183717514 1.1098079283248379e-07 6.954752176966952 3.632001584017513 GNVAGDSK(ub)NDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACK 49 1 P68104;A0A087WVQ9;A0A087WV01 P68104 EEF1A1 Elongation factor 1-alpha 1;Elongation factor 1-alpha 1 80444700.0 18819000.0 45705700.0 15920000.0 True False 24361566.477948915 43162137.61646066 13022723.352994366 1.0 1.7717307979981192 0.5345601796494489 24.538103567460226 -6.738037598456023 1.6938660261072058 1.4602263002690847 0.5341451846970441 0.5960600060749395 0.32426808337506924 0.32140299859212446 1.8099005456140849 0.1514918614790786 0.3725534087599547 1.8279419576953844e-07 6.738037598456023 -0.9260811155720406 GNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACK ddPTM_RPMI8226_Bortezomib_8h_R1 2 GNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACK 49 1 P68104;A0A087WVQ9;A0A087WV01 P68104 EEF1A1 Elongation factor 1-alpha 1;Elongation factor 1-alpha 0 1076791000.0 231324000.0 328281000.0 517186000.0 False True 350935420.04967856 269696690.67884004 414963960.40932333 1.0 0.7685080367227157 1.1824510627926381 28.386630325964497 -6.754960738186613 1.6316385446195105 0.864695727992534 1.1835877308699192 0.6699814754179085 0.09730780500369599 0.2914674780329669 1.5281180500978395 0.04708468109911631 0.11371310239844713 1.7580825438821611e-07 6.754960738186613 0.3188920028773852 GNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACK 49 1 P68104;A0A087WVQ9;A0A087WV01 P68104 EEF1A1 Elongation factor 1-alpha 1;Elongation factor 1-alpha 0 700759000.0 231324000.0 227675000.0 241760000.0 False True 299453478.077743 215004686.10759005 197762160.66708052 1.0 0.7179902784490997 0.6604102979085728 28.157756648056946 -13.999999999999998 0.22333344772844116 2.7270644307423355 0.6305774612801593 0.9995014496570083 0.0033131971594584876 13.092512712860309 0.14968493942783184 9.99004654289369 0.03118008190945317 1.0000000000000041e-14 13.999999999999998 -2.096486969462176 GNVETCAK(ub)AEEEIMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNVETCAKAEEEIMK 15 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 4550300.0 1885200.0 1143500.0 1521600.0 True False 2471515.456302772 972894.2573280894 1364159.428217842 1.0 0.39364279711342637 0.5519526186813887 21.23696449812095 -10.49194199630385 9.399776296371563 1.0000088378313368 0.47279770789778136 0.9366564042198547 0.0646297140187598 1.1970332222343215e-05 6.469179628125572e-07 0.06257849826533968 0.020859150505400412 3.221499020955717e-11 10.49194199630385 -0.5272111299335553 GNVETCAK(ub)AEEEIMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNVETCAKAEEEIMK 15 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 3760610.0 1839900.0 1040800.0 879910.0 True False 1529958.371390241 1035193.0038173747 1063895.112755832 1.0 0.6766151440295181 0.6953752027835195 20.545060968512754 -10.063217607122928 4.980084301096614 1.000006787049793 0.6859951734045587 0.9973300927460425 0.007658761922128396 5.771451494391554e-07 1.0857294205732862e-07 0.007415724523137808 0.0024718547804411174 8.645346274480476e-11 10.063217607122928 -0.31401161364523433 GNVGFVFTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNVGFVFTK 9 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 0 459380000.0 156950000.0 150080000.0 152350000.0 False True 205762969.90596217 127688649.00725807 136586283.44439286 1.0 0.6205618487408806 0.6638040047089889 27.6164081303498 -10.419304697293812 9.11710459605586 1.0000018171938292 0.64218292693801 0.9891651555985522 0.017653536249951952 6.520900578839275e-07 4.1514877435829516e-08 0.0170930500588743 0.0056976543248110755 3.8079856463567745e-11 10.419304697293812 -0.35781889025581914 GNVGFVFTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNVGFVFTK 9 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 0 323127000.0 90329000.0 35118000.0 197680000.0 False True 87461555.33859487 49140800.53795062 145901677.72711802 1.0 0.5618560103088616 1.6681806899303424 26.382145668465622 -6.799251272913981 1.4589212202395039 0.758024280567333 1.6831791390860724 0.8299713903230479 0.18757504065379652 0.22183221504408543 0.9322273802016391 0.10114886459684663 0.23534793813204052 1.5876279173961063e-07 6.799251272913981 0.9251548585187395 GNVGFVFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNVGFVFTK 9 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 0 191864000.0 59445000.0 75094000.0 57325000.0 False True 90182411.01162508 61692888.98789998 45994688.623559944 1.0 0.6840900381333493 0.5100183961330435 26.426342744912386 -12.228108551814838 0.08618289334168695 2.2755441553660902 2.2838456712589094e-21 0.9999047489082713 0.001979336052400412 6.28530769235139 0.06645499020345336 1.8442802946501178 0.3873309496117103 5.914137919461841e-13 12.228108551814838 -2.2755441553660902 GNVGFVFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNVGFVFTK 9 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 0 309234000.0 156950000.0 75772000.0 76512000.0 False True 214978656.41426957 72424142.49550362 58441441.414103195 1.0 0.3368899206251451 0.2718476447330892 27.67961819187269 -13.999999999999998 0.32828447425560653 8.144259013217749 0.26009605664553853 0.9997112699415306 0.0055903336198837306 18.679394807008414 0.1831274714609308 92.05849326741476 0.02097746186856222 1.0000000000000041e-14 13.999999999999998 -7.88416295657221 GNVGFVFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNVGFVFTK 9 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 0 203267000.0 90329000.0 70311000.0 42627000.0 False True 75112565.75319806 69932220.68735918 51540108.6150207 1.0 0.9310322445533248 0.6861715892433922 26.162550943899898 -6.947616763694833 0.5844287302646517 1.0028809459660963 0.6021193254661499 0.9990006889394524 0.00425687453828626 0.08445722031207147 0.04003443645382554 0.004439006889066117 0.020479848558752387 1.1281925727626764e-07 6.947616763694833 -0.40076162049994646 GNVGFVFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNVGFVFTK 9 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 0 225474000.0 59445000.0 100440000.0 65589000.0 False True 76952724.33613221 94850425.70614403 53652474.99997166 1.0 1.2325804774868532 0.6972134575199151 26.197469067004835 -6.788610332296351 1.5017069623756225 1.130221979599248 0.6917208555588965 0.7968622016126063 0.09878990006540413 0.23741823641502013 1.0577119565358726 0.051783097924241045 0.12136981695989867 1.6270079225826917e-07 6.788610332296351 -0.4385011240403516 GNVGFVFTK(ub)EDLTEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNVGFVFTKEDLTEIR 16 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 1 52387800.0 11331800.0 23933800.0 17122200.0 True False 14856099.537307303 20362970.333221722 15350558.991739966 1.0 1.3706807955941138 1.0332832620830894 23.824552050826544 -10.422368895994287 6.263510295402411 0.9999513240585352 1.2019820288386016 0.3233356976191222 0.13774196626259974 9.364941153904667e-05 8.636305840338677e-06 0.13340016051341613 0.04445602845074269 3.7812126661494374e-11 10.422368895994287 0.20203070478006646 GNVGFVFTK(ub)EDLTEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNVGFVFTKEDLTEIR 16 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 1 110279400.0 29304000.0 37795200.0 43180200.0 True False 28373760.560198627 52887020.45936423 31870010.241767015 1.0 1.8639411701229214 1.123221230197902 24.75805403731255 -10.20242391166122 4.313799680452796 0.9998355788624764 1.4935812001751616 0.3718733749808123 0.30239764936705055 212629522.0103874 124.28789917601591 377973.6983584727 0.10351875878539779 6.274456147479172e-11 10.20242391166122 0.4937456213126852 GNVGFVFTK(ub)EDLTEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNVGFVFTKEDLTEIR 16 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 1 242577000.0 35304000.0 52783000.0 154490000.0 True False 53558749.06812027 43363461.2545387 123954983.7846276 1.0 0.8096429063230287 2.314374139451461 25.67461892931187 -6.875157162969914 1.1064090127166084 0.8881202440702552 2.411602749264867 0.9695667144266856 0.11670771950081595 0.13200844584788715 0.29892074024336934 0.08157712539991528 0.1950707747686206 1.3330389432520623e-07 6.875157162969914 1.5234825051946115 up GNVGFVFTK(ub)EDLTEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNVGFVFTKEDLTEIR 16 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 1 56984800.0 11331800.0 17828200.0 27824800.0 True False 15521472.690380495 17040491.17402652 21253155.309744112 1.0 1.0978656158437494 1.3692744067330578 23.887762112349435 -6.953202703211829 0.5225020856417932 0.9954756232303593 1.4838283249900588 0.9994292413851998 0.0037318534846323866 0.08222463235553387 0.0308330368407519 0.0042110713087172924 0.022424248099555528 1.1137745675622247e-07 6.953202703211829 0.48835270175969947 GNVGFVFTK(ub)EDLTEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNVGFVFTKEDLTEIR 16 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 1 89598900.0 29304000.0 36010500.0 24284400.0 True False 24367574.3873143 35816504.28897535 29362155.761620764 1.0 1.4698428214349202 1.2049683441987 24.538459312746827 -10.150457934490802 4.517727674262517 0.9999575457356159 1.337405582821505 0.6838974761720829 0.10813455261166006 5.336960491186991e-05 1.0035805182989476e-05 0.10471600515764944 0.03490027677088663 7.071996963124783e-11 10.150457934490802 0.3374480370858891 GNVGFVFTK(ub)EDLTEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNVGFVFTKEDLTEIR 16 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;F8VPE8;F8VQY6;F8VRK7;F8VS58;F8VWV4 P05388 RPLP0 60S acidic ribosomal protein P0 1 209461000.0 35304000.0 52637000.0 121520000.0 True False 45701723.94587955 49707704.6783583 99404606.90049468 1.0 1.0876549151017296 2.1750734615221656 25.44574525140432 -6.922917233065148 0.8027731095402671 0.9784366328297472 2.3627752018034185 0.9949542441482186 0.03796553520078118 0.09648491320786112 0.09693444407804754 0.0332274650221177 0.10248930438215245 1.1942156739064107e-07 6.922917233065148 1.3843385689736714 up GNVGVVLFNFGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNVGVVLFNFGK 12 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 1025673600.0 300980000.0 361267300.0 363426300.0 False True 394587694.6944658 307367627.0489055 325822432.70723313 1.0 0.7789589771341047 0.8257288229921146 28.555770725094277 -10.658155758533525 6.627247151798173 1.0010725658032589 0.8023439000631098 0.9596997163321385 0.019093709616790935 0.0003041470759624469 1.5688386440271936e-05 0.01858276423212654 0.0061624682802626386 2.197071757661462e-11 10.658155758533525 -0.19872866574014902 GNVGVVLFNFGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNVGVVLFNFGK 12 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 1133478500.0 379898700.0 313567100.0 440012700.0 False True 367839023.71453446 438776078.26082414 324760173.7719497 1.0 1.1928480937937165 0.8828866782334205 28.454499301200457 -6.7384318540847525 1.6923096370402093 1.1149496208413485 0.882761356329807 0.5979592840919143 0.0810299992044527 0.32064962033239053 1.802476277556368 0.03788740138095779 0.09313739930788932 1.826283291934703e-07 6.7384318540847525 -0.2321882645115415 GNVGVVLFNFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNVGVVLFNFGK 12 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 2111167000.0 537299000.0 642087000.0 931781000.0 False True 815121864.8184905 527501558.2013715 747614076.9358804 1.0 0.647144409896101 0.9171807421732668 29.60244052473233 -9.78620408791142 5.780028497702795 1.0000000210066853 0.7821625760334942 0.4645762194626144 0.11024187101949914 2.982457131239627e-08 6.191629280855655e-09 0.10674124296515852 0.03558041087549075 1.636047513299971e-10 9.78620408791142 -0.21783744497319113 GNVGVVLFNFGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNVGVVLFNFGK 12 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 1253321300.0 300980000.0 349570100.0 602771200.0 False True 412260439.67866683 334124937.1082653 460409057.0225421 1.0 0.8104705301549097 1.116791747909172 28.61898078661717 -6.739335344493952 1.68902412168726 0.8871437912495891 1.116948826979078 0.6019805630046322 0.07963372152892975 0.3190300337793948 1.786770980345163 0.03730159019242171 0.09160535279268854 1.8224879080040792e-07 6.739335344493952 0.22980503572948885 GNVGVVLFNFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNVGVVLFNFGK 12 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 784344100.0 379898700.0 181626100.0 222819300.0 False True 315902601.4159838 180647644.1493418 269409785.4299598 1.0 0.571846016270892 0.8528254728589532 28.234904576634733 -10.189236282959028 7.119184108049757 1.0000004863061154 0.7123357445649228 0.582904218232402 0.1147093828075412 8.854024473045643e-07 1.0089407731230523e-07 0.1110670709828389 0.03702229410561155 6.467906260499397e-11 10.189236282959028 -0.2876647417411926 GNVGVVLFNFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNVGVVLFNFGK 12 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 2402975800.0 537299000.0 1223096000.0 642580800.0 False True 695544147.2466905 1155029632.4122055 525637687.8357918 1.0 1.6606129704122836 0.7557215310006231 29.37356684682478 -6.710947659174741 1.791573155024804 1.4057255306076877 0.7577621977702125 0.4697422934947689 0.2783365573364755 0.3731613409657871 2.335333818857565 0.12359927207455951 0.31366973885246136 1.9455945489998153e-07 6.710947659174741 -0.6479633328374752 GNVGVVLFNFGKEK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNVGVVLFNFGKEK 14 1 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 33667400.0 10647800.0 18496800.0 4522800.0 True False 13783786.99951667 17467436.820006043 3699696.807846922 1.0 1.2672451207072875 0.26840931363613296 23.716468977132298 -6.835500778165173 1.3030757578397487 1.1423507980680758 0.23836652992875643 0.9164494176474344 0.12203901512140075 0.17411732644469968 0.5762310660100206 0.07348658160067782 0.1691535872565829 1.4604921325418595e-07 6.835500778165173 -0.9039842681393194 down GNVQVVIPFLTESYSSSQDPPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNVQVVIPFLTESYSSSQDPPEK 23 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 11924200.0 4562400.0 5945500.0 1416300.0 False True 5981350.582344444 5058454.575377478 1269754.8621089163 1.0 0.8457044116940512 0.21228564429193256 22.512039849475304 -6.944278254096561 0.6184813201996412 1.0069403882515655 0.017579522829931412 0.9986722856808778 0.012419304266276143 0.08586791269290403 0.04612067693653518 0.012524573801644165 0.053575925239616545 1.1368986372214522e-07 6.944278254096561 -0.9893608654216342 down GNVQVVIPFLTESYSSSQDPPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNVQVVIPFLTESYSSSQDPPEK 23 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 29797600.0 10904000.0 7019600.0 11874000.0 False True 10557858.488547843 9822562.886730423 8763843.187635569 1.0 0.9303556111672648 0.8300777280867848 23.3318138984092 -6.965929265093148 0.34174454115409514 1.0106591122025244 0.7464329726920346 0.9999310164369075 0.0005792496077107594 0.07764718340503292 0.013756902528403848 0.0014081395715455688 0.008668477707924031 1.0816101021882631e-07 6.965929265093148 -0.2642261395104898 GNVQVVIPFLTESYSSSQDPPEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNVQVVIPFLTESYSSSQDPPEK 23 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 71212000.0 15070000.0 37369000.0 18773000.0 False True 22862291.764575474 30700209.98467035 15062508.321501786 1.0 1.3428316942503342 0.6588363264981488 24.44646669382107 -6.770453893160812 1.5729504872016822 1.1965270753617179 0.6549442584512575 0.7322099792394428 0.14450243320122064 0.26569630482659107 1.2974606762394731 0.07241273898699144 0.1722842383546885 1.696469698270791e-07 6.770453893160812 -0.5415828169104604 GNVQVVIPFLTESYSSSQDPPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNVQVVIPFLTESYSSSQDPPEK 23 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 19688800.0 4562400.0 3505400.0 11621000.0 False True 6249242.574224033 3350519.8371923487 8876359.142007705 1.0 0.5361481487391905 1.4203895970720708 22.575249910998195 -6.764179405679529 1.5968879391390642 0.7319726139069115 1.4242882465726874 0.7077480600641246 0.19523098443975748 0.2759467747149919 1.3877678627324537 0.09642397613782894 0.23076207802546217 1.7211574234104841e-07 6.764179405679529 0.6923156326657759 GNVQVVIPFLTESYSSSQDPPEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNVQVVIPFLTESYSSSQDPPEK 23 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 25412100.0 10904000.0 6580900.0 7927200.0 False True 9067159.129104398 6545447.385493631 9584740.868768444 1.0 0.7218851342846293 1.0570831207762392 23.112219173843478 -6.686405540237752 1.8789454766823432 0.8250586177498496 1.0558848218887813 0.3537637329634058 0.11770979762646747 0.42444173290354253 2.9022971359675154 0.0501669825442782 0.131245023445892 2.058706613915717e-07 6.686405540237752 0.23082620413893173 GNVQVVIPFLTESYSSSQDPPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNVQVVIPFLTESYSSSQDPPEK 23 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 39015000.0 15070000.0 13852000.0 10093000.0 False True 19508412.07411072 13081124.023113381 8256177.562925386 1.0 0.6705376108224163 0.42321115278685434 24.21759301591352 -7.6699117684596425 0.17532745701692565 1.2604499601372163 8.11991706777276e-12 0.9999532311141068 0.0016157710647895524 0.13376549801188034 0.020693617770506767 0.05003155001137615 0.08200524574594452 2.1383964833506784e-08 7.6699117684596425 -1.2604499601290964 down GNVQVVIPFLTESYSSSQDPPEK(ub)SIPICTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNVQVVIPFLTESYSSSQDPPEKSIPICTLK 31 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 152648000.0 83879000.0 15491000.0 53278000.0 True False 81216307.05804327 21676637.084497813 39322893.49426039 1.0 0.26690005824822916 0.4841748525472514 26.275266092973727 -10.209083859629885 6.540873003542545 1.0000041900951355 0.37553745539858047 0.9167616243333272 0.08870206333346423 5.419933843527072e-06 6.554723653578252e-07 0.08588597907732624 0.02862846783872841 6.178970764413476e-11 10.209083859629885 -0.6244667346965551 GNVQVVIPFLTESYSSSQDPPEK(ub)SIPICTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GNVQVVIPFLTESYSSSQDPPEKSIPICTLK 31 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 1365900000.0 270120000.0 703290000.0 392490000.0 True False 409791788.4171955 577782404.6701502 314914179.46552163 1.0 1.4099413921928785 0.7684736209133549 28.61031583439856 -6.734093202982445 1.7082903743839706 1.2455749854874487 0.7685619941602007 0.5780852630568697 0.1722820561292068 0.3286462514771315 1.8806870982527488 0.07986050522522158 0.1972578959009229 1.8446195069675313e-07 6.734093202982445 -0.47701299132724806 GNVQVVIPFLTESYSSSQDPPEK(ub)SIPICTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNVQVVIPFLTESYSSSQDPPEKSIPICTLK 31 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 211392000.0 83879000.0 36656000.0 90857000.0 True False 69749104.96974938 36458526.85235367 109854778.62469642 1.0 0.5227096013370489 1.574999115362715 26.055671368408003 -6.783373417724027 1.5224761342135475 0.7309254145762798 1.5842691840953673 0.7792005509485991 0.20215373934862155 0.24538241908943176 1.1235840815102265 0.10455204441264618 0.24603863816326518 1.6467458675786705e-07 6.783373417724027 0.8533437695190875 GNVQVVIPFLTESYSSSQDPPEK(ub)SIPICTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GNVQVVIPFLTESYSSSQDPPEKSIPICTLK 31 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 1256120000.0 270120000.0 714160000.0 271840000.0 True False 349675664.8612339 674416368.2029055 222367909.3139443 1.0 1.9286911729203189 0.6359261786266691 28.38144215649101 -6.713896740987461 1.7811375362797306 1.5686513139803053 0.638580545124645 0.4836397243958398 0.391116621984323 0.36731147263806524 2.2737867069319373 0.17458409555979484 0.44147188967467366 1.93242772156125e-07 6.713896740987461 -0.9300707688556603 GNVTLK(ub)ELNAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNVTLKELNAR 11 1 Q9NR31;H0Y5E8;Q9NR31-2 Q9NR31 SAR1A GTP-binding protein SAR1a 1 18905200.0 11330000.0 6138000.0 1437200.0 True False 9421397.004104244 6104933.375702386 1737711.8751380052 1.0 0.6479860017620416 0.18444312179828593 23.167509567746144 -7.4254526324796055 0.42779538388758753 1.027516318439091 7.375340864869807e-19 0.9988409433202181 0.011370520275264627 0.11364210872895102 0.04699843070932956 0.016625783074065367 0.062360504850841554 3.754459012773851e-08 7.4254526324796055 -1.027516318439091 down GNWAHSGFPEIAFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GNWAHSGFPEIAFGR 15 0 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 0 6138400.0 1537800.0 1733300.0 2867300.0 False True 2016070.6920763827 1474698.3963504806 2570619.3010837366 1.0 0.7314715709852742 1.2750640695223914 20.94311479611833 -6.772353762564357 1.5652144535310524 0.8464481793374322 1.2784162482044135 0.739600721739274 0.11324738443112686 0.2626195625374108 1.2700314341354129 0.057016761897009494 0.13544535830205864 1.689064512536064e-07 6.772353762564357 0.43196806886698125 GNWAHSGFPEIAFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNWAHSGFPEIAFGR 15 0 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 0 5623300.0 1537800.0 1573500.0 2512000.0 False True 2106366.2174824043 1503977.567131326 1918717.3362639495 1.0 0.7140152337464507 0.9109134586089503 21.00632485764122 -10.082616181689762 5.135503446149052 1.0000036463310287 0.8124643467966177 0.5474185877606914 0.08038336369702907 3.356034717126209e-06 5.993861559882545e-07 0.07783237060327641 0.025943619075672084 8.267683033904424e-11 10.082616181689762 -0.18753929953441095 GNWEQPQNQNQTQHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GNWEQPQNQNQTQHK 15 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77;Q5VU81;Q5VU80;Q5VU79;Q5VU78 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 5267390.0 1396900.0 669090.0 3201400.0 False True 1352556.1741244004 936261.1262582564 2362857.3000586615 1.0 0.6922160751396226 1.7469568697124882 20.367257082376458 -6.828598126113762 1.3340971282375629 0.8353714584195316 1.7745477323706713 0.9030522129659166 0.1378919626198674 0.18254882012016843 0.6359084436421724 0.08116407500513663 0.18680109076652063 1.4838905664202804e-07 6.828598126113762 0.9391762739511397 GNWEQPQNQNQTQHK(ub)QRPQATAEQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GNWEQPQNQNQTQHKQRPQATAEQIR 26 2 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77;Q5VU81;Q5VU80;Q5VU79;Q5VU78 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 1 4156300.0 1065100.0 1463200.0 1628000.0 True False 1458896.2532452284 1398550.9858446526 1243499.9297124653 1.0 0.9586363545273755 0.8523566545231528 20.476445861592712 -6.954872568183413 0.5025182318265361 1.002082777154102 0.8043066620189678 0.9995302295028123 0.0013478380819388078 0.0815862476066576 0.0283072248059521 0.0015732800883230687 0.00876794167611996 1.1095003199748162e-07 6.954872568183413 -0.19777611513513427 GNWEQPQNQNQTQHK(ub)QRPQATAEQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GNWEQPQNQNQTQHKQRPQATAEQIR 26 2 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77;Q5VU81;Q5VU80;Q5VU79;Q5VU78 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 1 7876000.0 2064000.0 3994500.0 1817500.0 True False 1716307.450703548 3972980.8356538275 2197530.846829477 1.0 2.3148421537325525 1.2803829791268844 20.710876582461523 -10.199572336722925 4.710281871430442 0.9998646207592174 1.7976125664338574 0.44217488074963407 0.4223161896016194 0.0006004971392103905 0.0001020443121317842 0.40897439268904684 0.13630196409472614 6.315789738102605e-11 10.199572336722925 0.7977479456746399 GPAASTQEK(ub)NPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPAASTQEKNPR 12 1 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 3247530.0 397730.0 1728400.0 1121400.0 True False 521427.8816227983 1470529.4572504316 1005368.285228369 1.0 2.8201972105400666 1.9281061114327867 18.99210820269479 -10.024719030325482 5.879739696413944 0.9999974670182857 2.3741516609866236 0.7598266299684743 0.36419466614927415 1.2092506318649e-05 2.0072089654780343e-06 0.3526306203381919 0.11754332306437369 9.446718402979401e-11 10.024719030325482 1.3741541939683377 GPAASTQEK(ub)NPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPAASTQEKNPR 12 1 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 6300740.0 187410.0 964530.0 5148800.0 True False 284314.67150624405 792402.085592713 4131137.4232007926 1.0 2.787060130927188 14.530159141330367 18.11712902284783 -6.933942186402563 0.7136897871693192 0.8448713189324627 17.202293125389804 0.9972579268078371 0.3142660152614368 0.09064188265256765 0.06802650845004522 0.29334928649496794 1.040478178795736 1.164281009029852e-07 6.933942186402563 16.357421806457342 GPAASTQEK(ub)NPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPAASTQEKNPR 12 1 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 2803330.0 187410.0 536620.0 2079300.0 True False 242605.9394033906 506756.6252731085 1700888.7354196748 1.0 2.0888055194333224 7.010911355272053 17.88825534494028 -6.942075849760553 0.6399595493555817 0.9461179968080403 8.423439470856483 0.9984233605893165 0.10383330065361228 0.08683223719904737 0.05039181067001417 0.10274094468087143 0.41991395282962374 1.1426787479146955e-07 6.942075849760553 7.477321474048442 GPAFNMASPESDFGINLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPAFNMASPESDFGINLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 4341030.0 926630.0 2189600.0 1224800.0 False True 1214820.9034976857 1862920.2149939502 1098069.4451112074 1.0 1.533493710579289 0.9038940982573398 20.21231220769769 -6.68215952430361 1.8942163544900656 1.3368926040753064 0.9062492620306949 0.3340210949434501 0.22600155138896097 0.43375135598659914 3.010831967885078 0.09567168553684473 0.25163153000567845 2.0789329167684583e-07 6.68215952430361 -0.4306433420446115 GPAFNMASPESDFGINLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPAFNMASPESDFGINLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 12453900.0 3990700.0 2671000.0 5792200.0 False True 3864017.4128987393 3737544.229080993 4275049.057724678 1.0 0.96726899226811 1.1063741699128595 21.881670164907295 -6.84467792693761 1.2604024698539367 0.9825826705496591 1.1113922728376704 0.9322064170821676 0.015461661983387678 0.16341354701449737 0.502230404238384 0.009610519158841696 0.02217776250238997 1.4299540201968687e-07 6.84467792693761 0.1288096022880113 GPAFNMASPESDFGINLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPAFNMASPESDFGINLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 4575530.0 926630.0 1352600.0 2296300.0 False True 1269230.1522341806 1292837.6595499415 1753961.2337830076 1.0 1.0185998632905195 1.3819095226311573 20.27552226922058 -6.917520418364634 0.8429174473530583 0.991245264667173 1.4372796902747418 0.9934638627620744 0.014213916291077721 0.09965273474475347 0.11333810258868772 0.01208858826398662 0.03539525744216172 1.2091483334712937e-07 6.917520418364634 0.4460344256075688 GPAFNMASPESDFGINLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPAFNMASPESDFGINLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 8909900.0 3990700.0 2532500.0 2386700.0 False True 3318443.867985776 2518856.9198381086 2885747.935146033 1.0 0.7590476199216232 0.869608783498158 21.66207544034157 -10.172658709375343 4.904590443024381 1.0000162545778968 0.8143282017094062 0.7899303221604526 0.04513640602348964 8.023172705857263e-06 1.3533894995130264e-06 0.043706961620959994 0.014567712402813881 6.71956703141757e-11 10.172658709375343 -0.18568805286849055 GPAGDATVASEK(ub)ESVM ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPAGDATVASEKESVM 16 1 Q15758;M0QXM4;Q15758-3;Q15758-2 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 1 13798500.0 5227300.0 5842800.0 2728400.0 True False 6853040.921245204 4971077.015056015 2446091.3406608533 1.0 0.725382654530066 0.35693517210406445 22.70831287104705 -6.967044509160196 0.3210319628284918 1.049851645520476 0.02056401405190757 0.9999492988992271 0.0018759503791143336 0.0772738488600538 0.012448871071477392 0.005561780040198969 0.03238004463370069 1.0788361508232334e-07 6.967044509160196 -1.0292876314685684 down GPAGDATVASEK(ub)ESVM ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPAGDATVASEKESVM 16 1 Q15758;M0QXM4;Q15758-3;Q15758-2 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 1 10629900.0 4042500.0 3041000.0 3546400.0 True False 3914173.0502526285 4255287.158605497 2617491.450280515 1.0 1.087148448464958 0.6687214429907684 21.900276109965017 -6.852369614921938 1.2237119061603405 1.0466147956935286 0.6512245344456398 0.9436670963886026 0.04278233217068054 0.15487207126720778 0.445111858446143 0.02734039812472948 0.06336629221352953 1.4048513886011595e-07 6.852369614921938 -0.3953902612478888 GPAGDATVASEK(ub)ESVM ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPAGDATVASEKESVM 16 1 Q15758;M0QXM4;Q15758-3;Q15758-2 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 1 17103100.0 4871600.0 6640200.0 5591300.0 True False 7390573.361665951 5455204.429880605 4486177.10424615 1.0 0.7381300696067938 0.6070134054166124 22.817254862510847 -13.999999999990996 0.08974020466126448 2.342416964587212 0.2773559530238159 0.9998436267422812 0.0020429140329795265 12.166072864950841 0.086976351437518 3.1184169380208933 0.2962594894326826 1.0000000000207333e-14 13.999999999990996 -2.065061011563396 GPAGDATVASEK(ub)ESVM ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPAGDATVASEKESVM 16 1 Q15758;M0QXM4;Q15758-3;Q15758-2 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 1 11598600.0 5227300.0 3058600.0 3312700.0 True False 7159974.072470915 2923460.9385623634 2530308.4871980855 1.0 0.4083060789008519 0.3533963198172411 22.77152293256994 -13.999999999999998 0.3363401636556002 7.6928022198917745 0.3443790843324513 0.9997278458581443 0.004829176818741894 19.373042405345295 0.18581076527729176 92.01785090286623 0.017190039555379833 1.0000000000000041e-14 13.999999999999998 -7.348423135559323 GPAGDATVASEK(ub)ESVM ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPAGDATVASEKESVM 16 1 Q15758;M0QXM4;Q15758-3;Q15758-2 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 1 9758100.0 4042500.0 4084600.0 1631000.0 True False 3361517.8631148697 4062595.4490703754 1972034.5591080477 1.0 1.2085598275851104 0.5866500311501274 21.680681385399293 -6.816266473471357 1.387888861201219 1.1128569933805592 0.5741243943844495 0.8755826654058952 0.09115959319528459 0.19838578519295558 0.751853639626498 0.05162657158913202 0.11912908160192645 1.5266290650398156e-07 6.816266473471357 -0.5387325989961097 GPAGDATVASEK(ub)ESVM ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GPAGDATVASEKESVM 16 1 Q15758;M0QXM4;Q15758-3;Q15758-2 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 1 17999700.0 6481900.0 5610200.0 5907600.0 True False 8390947.327350922 5297987.438237853 4832477.417094828 1.0 0.6313932422110036 0.5759155943385564 23.000402267631557 -13.999999999725155 0.266643291810856 3.794459602376917 0.5568930708242711 0.9995761621080625 0.003874670588353886 14.721199910796146 0.16343778523988936 22.254995551024827 0.023434213056513293 1.000000000632854e-14 13.999999999725155 -3.237566531552646 GPAK(ub)NSEPEEVIPSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPAKNSEPEEVIPSR 15 1 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 1 7771600.0 1946300.0 2548100.0 3277200.0 True False 2519523.717308676 2406295.995040083 2680783.226911635 1.0 0.9550598704466488 1.0640039657079374 21.264719606375067 -6.794722821595352 1.4777384323143334 0.9750361360982998 1.0653127019964326 0.8161628357632518 0.01916681129306918 0.22838649523255558 0.9851288159525715 0.010207322859695339 0.02381488258804759 1.604268951563066e-07 6.794722821595352 0.09027656589813282 GPAPGSK(ub)PVQFMDFEGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 GPAPGSKPVQFMDFEGK 17 1 Q8WUX1;C9JJU1;C9JMY2;C9JHH7;C9JWG4;C9JNK4 Q8WUX1 SLC38A5 Sodium-coupled neutral amino acid transporter 5 1 470529600.0 182251600.0 147202400.0 141075600.0 True False 238933612.52700517 125240375.71046121 126478450.20471142 1.0 0.5241639063918061 0.5293455737225601 27.832034581561864 -9.916949702293454 5.573187968860773 1.0000004355553629 0.5267547400563687 0.9999100933198387 0.0021154068335367416 2891637.1623619082 0.47563271667776197 16.163267337235254 0.0007241600250260449 1.210738346789051e-10 9.916949702293454 -0.4732456954989942 GPAPGSK(ub)PVQFMDFEGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 GPAPGSKPVQFMDFEGK 17 1 Q8WUX1;C9JJU1;C9JMY2;C9JHH7;C9JWG4;C9JNK4 Q8WUX1 SLC38A5 Sodium-coupled neutral amino acid transporter 5 1 378633500.0 108213700.0 90680500.0 179739300.0 True False 104778515.32668467 126889696.54256037 132660185.2665814 1.0 1.2110278156446115 1.2661010213111497 26.64276768390123 -13.682980399151559 0.19220605432442275 7.286880840884482e-06 1.305254188624281 0.9994774546698064 0.0026216256890235277 10.9166421747446 0.13712087293671962 4.107188702900935 0.03723525261176343 2.0750071658544785e-14 13.682980399151559 1.30524690174344 GPAPGSK(ub)PVQFMDFEGK ddPTM_RPMI8226_Bortezomib_8h_R1 2 GPAPGSKPVQFMDFEGK 17 1 Q8WUX1;C9JJU1;C9JMY2;C9JHH7;C9JWG4;C9JNK4 Q8WUX1 SLC38A5 Sodium-coupled neutral amino acid transporter 5 1 866499700.0 241171700.0 337106000.0 288222000.0 True False 365875100.912984 276946800.47880006 231254795.3678099 1.0 0.7569435574810166 0.6320593962003693 28.446775997646533 -13.999999999926 0.08506828867622149 2.2739876668440906 0.2917299918163129 0.9998649386331027 0.0017754409491709678 12.209259383855576 0.08349921873081373 2.8644144264846965 0.307268648895033 1.00000000017039e-14 13.999999999926 -1.9822576750277778 GPAPGSK(ub)PVQFMDFEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GPAPGSKPVQFMDFEGK 17 1 Q8WUX1;C9JJU1;C9JMY2;C9JHH7;C9JWG4;C9JNK4 Q8WUX1 SLC38A5 Sodium-coupled neutral amino acid transporter 5 1 490414400.0 182251600.0 113125100.0 195037700.0 True False 249634941.68430007 108126859.02732019 148973812.18751886 1.0 0.4331399214299993 0.5967666672877793 27.895244643084755 -10.78462264655932 10.662993146394259 1.0024502833878028 0.5149532943589633 0.9213619045908839 0.06680033927060365 0.003896687968951899 7.870742734809192e-05 0.06477145489442569 0.02155971679300444 1.6420158821096328e-11 10.78462264655932 -0.48749698902883953 GPAPGSK(ub)PVQFMDFEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GPAPGSKPVQFMDFEGK 17 1 Q8WUX1;C9JJU1;C9JMY2;C9JHH7;C9JWG4;C9JNK4 Q8WUX1 SLC38A5 Sodium-coupled neutral amino acid transporter 5 1 399457100.0 108213700.0 158554400.0 132689000.0 True False 89984486.2297473 157700235.9766156 160433656.41538212 1.0 1.7525269364096527 1.7829035107870135 26.423172959335506 -11.199050214259254 0.5410257401805403 1.2099232598350361e-13 1.780473871789342 0.9998796747456938 0.003972159269251911 3.359578067140659 0.2653400155574208 4.070845729515783 0.005754376505140638 6.3233873449771205e-12 11.199050214259254 1.780473871789221 GPAPGSK(ub)PVQFMDFEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GPAPGSKPVQFMDFEGK 17 1 Q8WUX1;C9JJU1;C9JMY2;C9JHH7;C9JWG4;C9JNK4 Q8WUX1 SLC38A5 Sodium-coupled neutral amino acid transporter 5 1 791311700.0 241171700.0 233937000.0 316203000.0 True False 312201519.85493094 220918200.30285004 258657298.5167641 1.0 0.7076141090072302 0.828494680733627 28.217902319738982 -10.054533990000847 4.9215218227217195 1.0000051553071583 0.768054395032012 0.8307682404931055 0.04934928676492218 2.7915415052987722e-06 5.363263194056708e-07 0.04778330361438798 0.01592741381460091 8.819947702299411e-11 10.054533990000847 -0.23195076027514627 GPATVEDLPSAFEEK(ub)AIEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPATVEDLPSAFEEKAIEK 19 1 O14908;K7EM11;O14908-2 O14908 GIPC1 PDZ domain-containing protein GIPC1 1 4531400.0 1533600.0 1868000.0 1129800.0 True False 2010564.4514035254 1589301.681406971 1012899.1338068601 1.0 0.7904753713801708 0.5037884426434478 20.939169153773747 -6.966739729262426 0.32682136449168037 1.0362477614958119 0.2486753477541061 0.9999446439762439 0.0015132608802274346 0.0773754665196898 0.012804482900724017 0.004231915034246453 0.02507057965399833 1.0795935239606296e-07 6.966739729262426 -0.7875724137417057 GPAVGIDLGTTYSCVGVFQHGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPAVGIDLGTTYSCVGVFQHGK 22 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 153280000.0 69585000.0 59579000.0 24116000.0 False True 91226608.86209853 50690045.437123105 21620707.657006763 1.0 0.5556497832090638 0.23700001487164138 26.442951353451313 -8.102125617170577 0.2701805069756203 1.1639282242137132 2.1070358153256997e-21 0.9993951490219972 0.007695355151153862 0.09107267440961729 0.055018999455101136 0.07450068156785208 0.09683143933579702 7.904499618451006e-09 8.102125617170577 -1.1639282242137132 down GPAVGIDLGTTYSCVGVFQHGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPAVGIDLGTTYSCVGVFQHGK 22 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 538390000.0 251550000.0 150210000.0 136630000.0 False True 243564682.9415086 210189636.3348017 100842504.18785983 1.0 0.862972553312576 0.4140276125832122 27.85972971566422 -6.9494547668526385 0.5647961465819427 1.005730788410449 0.2496361260316534 0.999157809721386 0.007262807742768006 0.08370539009326483 0.03687393030901239 0.007740976160881786 0.037359630185450035 1.1234279721666214e-07 6.9494547668526385 -0.7560946623787955 down GPAVGIDLGTTYSCVGVFQHGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPAVGIDLGTTYSCVGVFQHGK 22 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 3896024400.0 1015924400.0 1527800000.0 1352300000.0 False True 1541231588.822251 1255152153.2441173 1085017312.265854 1.0 0.8143825771201948 0.7039936892903822 30.5214365146332 GPAVGIDLGTTYSCVGVFQHGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPAVGIDLGTTYSCVGVFQHGK 22 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 347322000.0 69585000.0 70647000.0 207090000.0 False True 95312454.96391802 67525581.94161229 158179607.15242884 1.0 0.7084654567671678 1.6595901051159594 26.506161414974205 -6.824424305717578 1.3525585176993182 0.8435261894422076 1.6824027981885656 0.894269729765775 0.12937147866929366 0.18779514195145258 0.6738141773307379 0.07513807195401707 0.17301679630604028 1.4982203589011683e-07 6.824424305717578 0.838876608746358 GPAVGIDLGTTYSCVGVFQHGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPAVGIDLGTTYSCVGVFQHGK 22 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 561671000.0 251550000.0 94651000.0 215470000.0 False True 209174970.5544948 94141096.27624747 260523780.7792836 1.0 0.45005908702504915 1.2454825741754378 27.640134991098495 -6.720744498280897 1.7570227836475634 0.6656826623677876 1.2442624071836084 0.5158736635354071 0.23139601549762298 0.35386325922553136 2.135427244224598 0.10456255979581636 0.26222325407170766 1.902197040804604e-07 6.720744498280897 0.5785797448158208 GPAVGIDLGTTYSCVGVFQHGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPAVGIDLGTTYSCVGVFQHGK 22 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 3050284400.0 1015924400.0 1250000000.0 784360000.0 False True 1315134162.6638172 1180436401.161691 641614528.2132328 1.0 0.8975786917212351 0.48787001845776423 30.29256283672565 -6.94487337478651 0.6125498639947018 1.0045164214608133 0.3595023842586634 0.998735045268063 0.007869595003963059 0.08561202519341378 0.045002086987059944 0.007980070240535023 0.03457895498108601 1.1353417937226998e-07 6.94487337478651 -0.64501403720215 down GPAYGLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPAYGLSR 8 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 16147410.0 914410.0 9073100.0 6159900.0 False True 1198800.3651590368 7719428.846666794 5522532.637933152 1.0 6.4392947074575755 4.606715845636662 20.193159997738626 -10.535087085925905 7.80315678288112 0.9989342934479514 5.523005276547113 0.8903759504067937 0.7481471874785997 0.01386885435789125 0.000826308818605098 0.7242945727745808 0.24146346646804448 2.916842062149432e-11 10.535087085925905 4.524070983099161 GPAYGLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPAYGLSR 8 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 17440000.0 5435900.0 2005200.0 9998900.0 False True 5263340.329961228 2805886.8169798595 7379888.129429796 1.0 0.533100016544157 1.4021301429854829 22.3275472524834 -6.760781917669645 1.6095330296366985 0.729054722724883 1.4054248816493655 0.6941054060340368 0.19640241014697832 0.2816290157081494 1.438121455279793 0.09626966146258326 0.2311723204104468 1.7346748514788027e-07 6.760781917669645 0.6763701589244825 GPAYGLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPAYGLSR 8 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 21422110.0 914410.0 11842000.0 8665700.0 False True 1252492.088001097 11318781.283742733 6619040.135693674 1.0 9.037008211211006 5.2846961662306935 20.256370059261517 -9.797200988947157 10.89325675378 1.0000000836238458 7.160849633562055 0.7823421602157277 1.5318749776515959 0.0 0.0 1.4832315250273076 0.4944105230770158 1.5951407545726532e-10 9.797200988947157 6.160849549938209 GPCIIYNEDNGIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPCIIYNEDNGIIK 14 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 38278900.0 4339900.0 16318000.0 17621000.0 False True 5689650.927651379 13883418.007065818 15797747.95256741 1.0 2.440117712598711 2.7765759540345885 22.439908712120605 -10.195217759188663 0.3319620488135558 4.2086792528113116e-14 2.858366339063324 0.9989492227790748 0.024977070006972933 1.61666914156684 0.15292853766267583 1.5787043675647214 0.10603764438932835 6.379435353146714e-11 10.195217759188663 2.8583663390632816 GPCIIYNEDNGIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPCIIYNEDNGIIK 14 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 32631900.0 4339900.0 13312000.0 14980000.0 False True 5944478.311387621 12723831.82310279 11442032.522784216 1.0 2.140445495230121 1.9248169348797406 22.503118773643497 -10.160831878015633 4.40904159825664 0.9997960347622719 2.032631215093112 0.968332919110944 0.08802999127186749 30822773.665363427 25.688683694281497 64483.56939926408 0.030135007452946044 6.905070578684098e-11 10.160831878015633 1.0328351803308402 GPCIIYNEDNGIIK(ub)AFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPCIIYNEDNGIIKAFR 17 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 71260000.0 12065000.0 15096000.0 44099000.0 True False 15817331.837626185 12843735.643747108 39536058.507478066 1.0 0.8120039318638114 2.4995403089053174 23.915002922096072 -6.879243332932379 1.0839775853791158 0.8846007014379228 2.617428763760776 0.973071392111093 0.12391335961466955 0.12830399728879793 0.27633590303018957 0.08811539977195541 0.21268784006994737 1.3205555264948963e-07 6.879243332932379 1.7328280623228531 up GPCIIYNEDNGIIK(ub)AFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPCIIYNEDNGIIKAFR 17 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 37776900.0 11676000.0 8691900.0 17409000.0 True False 11305351.771119261 12162620.997659707 12849060.64119485 1.0 1.0758286202761451 1.136546734796803 23.430502547106258 -6.973641140728157 0.14716278246817532 0.9265478070293102 1.28742066427481 0.9999986513675586 6.461154427454889e-05 0.07513776118985278 0.004486070457677209 0.0031883629217023366 0.00766402080190032 1.0625732030460602e-07 6.973641140728157 0.3608728572454999 GPCIIYNEDNGIIK(ub)AFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPCIIYNEDNGIIKAFR 17 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 120748000.0 24988000.0 25575000.0 70185000.0 True False 37908622.86749913 21010941.431612946 56312903.98682166 1.0 0.5542523004608175 1.485490627914669 25.176022711901396 -6.776518234249909 1.5491967934009625 0.7464691318935139 1.49211071653353 0.7549724234113818 0.18824545278481022 0.25601379738836405 1.2133233994344101 0.0957253601336266 0.2265603656329735 1.672945394785914e-07 6.776518234249909 0.745641584640016 GPCIIYNEDNGIIK(ub)AFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPCIIYNEDNGIIKAFR 17 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 120650700.0 12065000.0 19495000.0 89090700.0 True False 16525756.544365456 18633646.43865602 68049311.5405616 1.0 1.1275517939908937 4.117772844945085 23.978212983618963 -6.915855263487603 0.8549073167193945 0.9236639461372724 4.55681400992717 0.992949901214571 0.1209605753615169 0.10067213023006287 0.1187069136797541 0.10199393454093027 0.2943950410793294 1.2137933016968526e-07 6.915855263487603 3.633150063789898 up GPCIIYNEDNGIIK(ub)AFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPCIIYNEDNGIIKAFR 17 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 153851200.0 11676000.0 4180300.0 137994900.0 True False 9709111.334503192 4157779.894175416 166848995.5736721 1.0 0.4282348559955169 17.184785489145863 23.210907822540534 -6.8990014316421915 0.9675821856055242 0.2841069469678268 18.908288830670745 0.9860622486573318 0.9170594360304865 0.11214325991333077 0.18160442884266562 0.7121742773058998 1.843799185881146 1.2618233750108586e-07 6.8990014316421915 18.624181883702917 up GPCIIYNEDNGIIK(ub)AFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPCIIYNEDNGIIKAFR 17 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 180445500.0 24988000.0 29142000.0 126315500.0 True False 32347458.58711868 27520222.082123157 103327375.10648005 1.0 0.850769219102801 3.1942965419739897 24.947149033993846 -6.891711660266936 1.0121828332806657 0.8791980781899636 3.402768182952233 0.9819720921882628 0.14384256933949327 0.11776610667230848 0.21381411810350007 0.10802925750309965 0.2710375590791502 1.283182238946631e-07 6.891711660266936 2.5235701047622694 up GPDAASK(ub)LPLVTPHTQCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPDAASKLPLVTPHTQCR 18 1 P62191 P62191 PSMC1 26S protease regulatory subunit 4 1 9220900.0 2820900.0 4200000.0 2200000.0 True False 3698227.2176344586 3573376.371471774 1972365.1038901487 1.0 0.9662403527919129 0.5333271829500396 21.818402435408657 -6.922460421695151 0.806283519650171 1.008731966635981 0.4594099320971361 0.9948371290173849 0.015267487016348334 0.09674600125380005 0.09827568638132618 0.013328795630038323 0.04091460847111639 1.195472467002287e-07 6.922460421695151 -0.549322034538845 GPDAASK(ub)LPLVTPHTQCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPDAASKLPLVTPHTQCR 18 1 P62191 P62191 PSMC1 26S protease regulatory subunit 4 1 9779400.0 2820900.0 3531700.0 3426800.0 True False 3863862.961956117 3375657.8162298766 2617460.417161349 1.0 0.8736484314963692 0.6774206132394083 21.88161249693155 -6.964674062223076 0.363614365799037 1.0162259163482108 0.5280808119875054 0.999906251747717 0.0012850153260427087 0.0780718707813384 0.015251805582646957 0.0026143388822970114 0.016724787495598116 1.0847407059287797e-07 6.964674062223076 -0.48814510436070535 GPDAASK(ub)LPLVTPHTQCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPDAASKLPLVTPHTQCR 18 1 P62191 P62191 PSMC1 26S protease regulatory subunit 4 1 8797300.0 3322500.0 3473500.0 2001300.0 True False 2762805.961706651 3454787.5660642283 2419762.577034299 1.0 1.2504633383410408 0.8758351511372713 21.397702811201803 -6.726503020168439 1.735733616986189 1.151309193534173 0.8761863249135375 0.5430903338827306 0.10532094353363228 0.34283318486940156 2.0217883064683972 0.048114943637877904 0.11988084077779411 1.8771413643228713e-07 6.726503020168439 -0.2751228686206355 GPDGLTAFEATDNQAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPDGLTAFEATDNQAIK 17 0 P58546;C9JL85 P58546 MTPN Myotrophin 0 32987700.0 10377000.0 2987700.0 19623000.0 False True 10047587.815082628 4180704.1906496766 14483147.622618586 1.0 0.4160903360679208 1.4414551919494203 23.260345850698076 -6.752217205865804 1.6414590445736068 0.6575776530156078 1.443866195794147 0.6585387749981497 0.24539523608119893 0.2961887154998749 1.5707810155635369 0.1180599475975243 0.2859739016503665 1.76922388623974e-07 6.752217205865804 0.7862885427785392 GPDSHYGTK(ub)GLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPDSHYGTKGLK 12 1 Q9H0C5 Q9H0C5 BTBD1 BTB/POZ domain-containing protein 1 1 6863800.0 1375800.0 2597900.0 2890100.0 True False 1803687.1232661523 2210303.4465348874 2591060.1757967793 1.0 1.2254361735046522 1.436535273980798 20.782517672407547 -6.971917770788564 0.20732765143353846 0.8856386872916123 1.7822082475509748 0.9999937276811376 0.000446374645978108 0.07568520404878129 0.006755880166037366 0.006457666982807405 0.02201227026167788 1.0667980893997927e-07 6.971917770788564 0.8965695602593625 GPDSHYGTK(ub)GLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPDSHYGTKGLK 12 1 Q9H0C5 Q9H0C5 BTBD1 BTB/POZ domain-containing protein 1 1 22749100.0 3875200.0 11216000.0 7657900.0 True False 5878961.715068547 9214417.168992022 6144312.708423195 1.0 1.5673545118305954 1.0451356899764321 22.48712995214285 -10.389984019205674 3.544979713279667 0.997938093780144 1.3062451004734097 0.3143802667644182 0.2131949432320235 153869759.9041239 312799700.6709382 3561249.096286632 0.07802132313491661 4.073952685085413e-11 10.389984019205674 0.3083070066932657 GPDSHYGTK(ub)GLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPDSHYGTKGLK 12 1 Q9H0C5 Q9H0C5 BTBD1 BTB/POZ domain-containing protein 1 1 7029900.0 1375800.0 1895200.0 3758900.0 True False 1884470.4395970176 1811463.7974116888 2871125.2369755446 1.0 0.9612588021274875 1.5235713846429542 20.84572773393044 -6.89038680016388 1.020067920023376 0.9700659054269986 1.5723079178459567 0.9811455268299644 0.035211293220966645 0.11883084884927915 0.22000746570929788 0.026287411732435158 0.06562836277149167 1.287102695531087e-07 6.89038680016388 0.6022420124189581 GPDSHYGTK(ub)GLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPDSHYGTKGLK 12 1 Q9H0C5 Q9H0C5 BTBD1 BTB/POZ domain-containing protein 1 1 15501600.0 3875200.0 5339500.0 6286900.0 True False 5016522.791612075 5042352.1312022805 5142748.709041475 1.0 1.0051488532322417 1.0251620340767629 22.2582562742353 -6.945534972120952 0.6058966363285626 0.9997771831296369 1.031568591397401 0.9988022616019859 0.00037557392420241835 0.08532998770907985 0.043777393045514826 0.0003832596618703413 0.0016851605563350303 1.1336135487428665e-07 6.945534972120952 0.031791408267764165 GPDSHYGTK(ub)GLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPDSHYGTKGLR 12 1 Q9BX70-2;Q9BX70 Q9BX70-2 BTBD2 BTB/POZ domain-containing protein 2 1 10822300.0 2930100.0 3975100.0 3917100.0 True False 3841389.475128764 3382030.57481844 3511796.0674764076 1.0 0.8804185560239434 0.9141994297151271 21.873196814200934 -10.855623081422419 6.932864541558594 1.0102467654144234 0.8973089928695352 0.9249330826036136 0.013790983934801458 0.002340612186178272 4.874319447859386e-05 0.014309148805559302 0.004451020925608338 1.394366430594274e-11 10.855623081422419 -0.11293777254488813 GPDSHYGTK(ub)GLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPDSHYGTKGLR 12 1 Q9BX70-2;Q9BX70 Q9BX70-2 BTBD2 BTB/POZ domain-containing protein 2 1 11759000.0 2876300.0 4658600.0 4224100.0 True False 2784993.430907019 6518803.274278063 3117681.489716304 1.0 2.3406889229735146 1.1194573944474027 21.40924249394189 -6.623830953121604 2.1019578138446016 1.8871306445070282 1.124139355728421 0.09611131654016714 0.5759683415404653 0.5751693370587961 4.833803626919156 0.22470025665209387 0.6386898369646696 2.377765639482392e-07 6.623830953121604 -0.7629912887786072 GPDSHYGTK(ub)GLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPDSHYGTKGLR 12 1 Q9BX70-2;Q9BX70 Q9BX70-2 BTBD2 BTB/POZ domain-containing protein 2 1 23276500.0 5197600.0 10182000.0 7896900.0 True False 7885139.195458365 8364942.547670891 6336074.253665767 1.0 1.0608490656054468 0.8035462782084025 22.910704792294936 -6.844353895090708 1.2621072167587613 1.032374686309641 0.794332063488089 0.9316682062304491 0.028701712825143423 0.1637777938942697 0.5048910727150857 0.01781831045698969 0.04110872761738612 1.431021322591774e-07 6.844353895090708 -0.23804262282155197 GPDSHYGTK(ub)GLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPDSHYGTKGLR 12 1 Q9BX70-2;Q9BX70 Q9BX70-2 BTBD2 BTB/POZ domain-containing protein 2 1 9185400.0 2930100.0 2557500.0 3697800.0 True False 4013437.1529751574 2444501.193478469 2824455.798581542 1.0 0.6090792256872297 0.7037498510442042 21.936406875723826 -9.818883189076065 6.180538369716526 1.000000017222532 0.6564145383654952 0.9461269433436522 0.038649120959933725 9.200222804188248e-09 1.7142443187992949e-09 0.03742185268600447 0.012473950151830197 1.5174584589644535e-10 9.818883189076065 -0.34358547885703683 GPDSHYGTK(ub)GLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPDSHYGTKGLR 12 1 Q9BX70-2;Q9BX70 Q9BX70-2 BTBD2 BTB/POZ domain-containing protein 2 1 10993300.0 2876300.0 4688200.0 3428800.0 True False 2391770.891695062 4662943.736065159 4145746.2270200388 1.0 1.949577926655217 1.7333375205021933 21.189647769376165 -10.413882295116817 6.588790915757421 0.9998843287865544 1.841457723578705 0.9528072367662651 0.0882797761411833 0.0001500211328866191 1.3345419425092283e-05 0.08548801065697897 0.02849217523347682 3.8558284629291873e-11 10.413882295116817 0.8415733947921507 GPDSHYGTK(ub)GLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPDSHYGTKGLR 12 1 Q9BX70-2;Q9BX70 Q9BX70-2 BTBD2 BTB/POZ domain-containing protein 2 1 20469400.0 5197600.0 8570200.0 6701600.0 True False 6728395.660013135 8093260.836188728 5481977.5642228145 1.0 1.202851503559309 0.8147525563638024 22.681831114387386 -6.764640995410325 1.5947085797246003 1.1171417698431214 0.8129844167696347 0.709761608108658 0.08538727311373519 0.2751738156429711 1.3801226845594974 0.042224593734508244 0.1010247813872034 1.719329063682165e-07 6.764640995410325 -0.3041573530734867 GPDWK(ub)WGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPDWKWGK 8 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 11645200.0 2945000.0 2911700.0 5788500.0 True False 2851512.587011496 4074356.9943149057 4272318.19872229 1.0 1.4288406135303093 1.4982638401045452 21.443295970321813 -11.967628368594829 0.29574312363380295 1.2954192220526457e-10 1.5177917906687792 0.9994562253552357 0.005138354347036898 5.12201105797608 0.16290578980902948 3.174819572225992 0.02553246528178232 1.0773867530661213e-12 11.967628368594829 1.5177917905392373 GPDWK(ub)WGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPDWKWGK 8 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 10421700.0 2945000.0 4514200.0 2962500.0 True False 2448897.9856210947 4489881.10860146 3581945.0529476358 1.0 1.8334292138603425 1.4626763033737296 21.22370124575609 -10.048191384643395 5.018007104416929 0.9999891500953265 1.6480527586210578 0.8029056448586652 0.15135924190461547 1.8372907668347956e-05 3.4847192369220154e-06 0.14655540805057635 0.04885098526393202 8.949702836442497e-11 10.048191384643395 0.6480636085257313 GPFADENFK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPFADENFKLR 11 1 C9JQD4;O43447;O43447-2;H0YEL5 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 1 5950600.0 2071300.0 1695900.0 2183400.0 True False 2715494.3584977305 1442878.3305664225 1957482.7126517072 1.0 0.5313501484733902 0.7208568511755733 21.37278343535712 -10.176287061065597 5.36285697356013 1.000014298705494 0.6261034998243891 0.8384569166445084 0.07736578740993529 1.3226941181340448e-05 2.0316154236670997e-06 0.07491196348803307 0.024969700517028157 6.66366167219156e-11 10.176287061065597 -0.373910798881105 GPFADENFK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPFADENFKLR 11 1 C9JQD4;O43447;O43447-2;H0YEL5 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 1 10178600.0 3535800.0 2504700.0 4138100.0 True False 3423557.964399065 3504839.7718379474 3054207.4696610053 1.0 1.0237419106917764 0.8921150164306064 21.70706500828939 -6.860220257452304 1.1845007401124559 1.0128904652589745 0.8857104669384913 0.9539156821903609 0.01229634049810353 0.14658143749565727 0.39064881493862924 0.008095497482106884 0.01890354221332567 1.3796843643086269e-07 6.860220257452304 -0.1271799983204832 GPFADENFK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPFADENFKLR 11 1 C9JQD4;O43447;O43447-2;H0YEL5 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 1 110244500.0 6296500.0 21737000.0 82211000.0 True False 9552250.835809538 17857862.51804382 65961959.81563864 1.0 1.869492627967657 6.905383971739941 23.187409290644972 -6.936586943697049 0.6905840127879761 0.9387727327725727 8.137098081066782 0.9976818339731549 0.12533707137810984 0.089358744544402 0.06196201018360649 0.11905520647848787 0.4403397190059994 1.1572123404749796e-07 6.936586943697049 7.198325348294209 GPFADENFK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPFADENFKLR 11 1 C9JQD4;O43447;O43447-2;H0YEL5 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 1 7879100.0 2071300.0 2440900.0 3366900.0 True False 2837115.584777801 2333052.967023106 2571707.5634821225 1.0 0.8223327169117882 0.9064514598137302 21.435993496880013 -10.209779490023154 4.81878904530698 1.0000211046755958 0.8643920883623986 0.776043835526746 0.03434133298693101 7.787611127419913e-06 1.277032160938507e-06 0.03325602581302945 0.011083617561902024 6.169081531420534e-11 10.209779490023154 -0.13562901631319724 GPFADENFK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPFADENFKLR 11 1 C9JQD4;O43447;O43447-2;H0YEL5 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 1 10183200.0 3535800.0 2637800.0 4009600.0 True False 2940174.362498834 2623589.6478376933 4847988.821704245 1.0 0.8923245101722208 1.6488779997333127 21.487470283723667 -6.870831758580046 1.1297599387018475 0.9387920977940961 1.6938773979329205 0.9655025654408731 0.06206650672947612 0.13605602478613513 0.324065641033733 0.04261604730899586 0.10103799764393182 1.3463818281487634e-07 6.870831758580046 0.7550853001388244 GPFADENFK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPFADENFKLR 11 1 C9JQD4;O43447;O43447-2;H0YEL5 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 1 130537500.0 6296500.0 25336000.0 98905000.0 True False 8150943.372570562 23926029.327866063 80905304.85099925 1.0 2.935369347354515 9.925882336915825 22.95853561273742 -6.947221008884357 0.5885630968220729 0.9188480482651922 12.29328926457706 0.9989647629765969 0.12335387513671973 0.08462121950753394 0.040731308711665616 0.12807561071470797 0.5853805164528861 1.1292211171057476e-07 6.947221008884357 11.374441216311869 GPFELEAFYSDPQGVPYPEAK(ub)IGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPFELEAFYSDPQGVPYPEAKIGR 24 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 29586500.0 9396100.0 7519400.0 12671000.0 True False 9097825.948665103 10521935.633152967 9352084.978148095 1.0 1.1565329665046868 1.0279472294719267 23.117090403887833 -10.107372866301732 4.032363439946021 0.9999775680671642 1.0922400979320186 0.4069182683015685 0.05249490744328601 7108958.598011279 8920952.026373174 1105.9993621115368 0.017970403153810117 7.80957021037579e-11 10.107372866301732 0.09226252986485439 GPFELEAFYSDPQGVPYPEAK(ub)IGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPFELEAFYSDPQGVPYPEAKIGR 24 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 141723000.0 17379000.0 31937000.0 92407000.0 True False 26365213.575086728 26237592.825080097 74142715.94657312 1.0 0.9951595025148128 2.812141678102421 24.652132347728845 -6.906298971150474 0.920578257183991 0.9369483305556734 3.029270025883116 0.9894481494621269 0.08786805452756098 0.10691633038101662 0.15242263797021274 0.07064745052924828 0.19036095912096723 1.2407978401995516e-07 6.906298971150474 2.092321695327443 up GPFELEAFYSDPQGVPYPEAK(ub)IGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPFELEAFYSDPQGVPYPEAKIGR 24 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 29963100.0 9396100.0 10056000.0 10511000.0 True False 7813273.467807938 10001826.33204027 12708801.502627054 1.0 1.2801070349386279 1.6265655560360908 22.89749567932211 -6.96826401366757 0.29673712495499105 0.9375342820849073 1.9799441847815238 0.9999654973751444 0.001505303124255208 0.07687013220991769 0.01103572717913758 0.005842956027911743 0.031181489725704097 1.0758110142942048e-07 6.96826401366757 1.0424099026966165 GPFELEAFYSDPQGVPYPEAK(ub)IGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPFELEAFYSDPQGVPYPEAKIGR 24 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 101877000.0 17379000.0 20513000.0 63985000.0 True False 22497458.091305245 19371433.517623786 52340386.54154179 1.0 0.8610498767907653 2.3265022354578875 24.423258669821294 -6.883664357001964 1.0591776161317668 0.90888992719037 2.4379296090870866 0.9765219430822843 0.1012070432145166 0.12443254073433631 0.2531052183816708 0.07334790781863013 0.1791422108674939 1.3071807479976266e-07 6.883664357001964 1.5290396818967165 up GPFLVALGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPFLVALGK 9 0 Q96HC4-7;Q96HC4-4;Q96HC4;Q96HC4-6;H0Y8Y3;A0A0A0MSP3 Q96HC4-7 PDLIM5 PDZ and LIM domain protein 5 0 3667900.0 1149200.0 1070100.0 1448600.0 False True 1506612.32886863 910445.2512171305 1298712.7679523942 1.0 0.6042996156156619 0.8620085891157182 20.52287680963812 -10.134164642325755 5.096851241929226 1.0000103092367318 0.7331541023652749 0.588401905088729 0.10520924787003931 1.2325433025754133e-05 2.0938549330828596e-06 0.10187235086625278 0.033956138738765275 7.342354645470434e-11 10.134164642325755 -0.26685620687145695 GPFVEAEVPDVDLECPDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPFVEAEVPDVDLECPDAK 19 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9478200.0 0.0 6568400.0 2909800.0 False True 0.0 5588420.323422673 2608721.808772526 0.0 GPFVEAEVPDVDLECPDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPFVEAEVPDVDLECPDAK 19 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 10153800.0 3548100.0 2340500.0 4265200.0 False True 3435467.5076317494 3275073.855546262 3148016.166742737 1.0 0.9533124234971865 0.9163283191442064 21.712075007537248 -6.97375208094544 0.14244356125546917 1.0478348367032668 0.8208393302026122 0.9999988117490931 3.686954440710703e-05 0.07510302254580087 0.004323251965098686 0.002038037806132302 0.004764135956936676 1.0623018041410113e-07 6.97375208094544 -0.2269955065006546 GPFVEAEVPDVDLECPDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPFVEAEVPDVDLECPDAK 19 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 11385500.0 0.0 5270600.0 6114900.0 False True 0.0 5037727.464456548 4670686.560318649 0.0 GPFVEAEVPDVDLECPDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPFVEAEVPDVDLECPDAK 19 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7014400.0 3548100.0 1857900.0 1608400.0 False True 2950402.357481228 1847891.1239357258 1944709.0035986432 1.0 0.6263183457842946 0.6591334902737978 21.492480282971524 -9.935890725490648 5.7579053608206126 1.0000002666618995 0.6427259184923468 0.9937126479383399 0.013396726640204852 4.586168397559567e-08 8.476214921427975e-09 0.012971334553217936 0.0043237749307821725 1.15906895727818e-10 9.935890725490648 -0.3572743481695526 GPFVEAEVPDVDLECPDAKLK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPFVEAEVPDVDLECPDAKLK 21 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 7846100.0 3322800.0 3019900.0 1503400.0 True False 3217319.532808763 4225761.818570458 1109614.4389667602 1.0 1.3134417565548149 0.34488785700376234 21.617427795804716 -6.819583994628979 1.3736846752034084 1.1690139634245302 0.32393306064573185 0.8834228907797146 0.13777817180405555 0.1940216391232495 0.7195219076628399 0.07881960368502056 0.18168592938021938 1.5150117648441044e-07 6.819583994628979 -0.8450809027787984 down GPGCGFWAAGWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPGCGFWAAGWR 12 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 10135100.0 2630300.0 2353500.0 5151300.0 False True 3448348.7718614326 2002366.973871148 4618292.890758782 1.0 0.5806741447415316 1.3392766208697064 21.71747426776169 -6.7566876980185135 1.6252917919384862 0.7554266881821217 1.3415695135378576 0.6771590009131443 0.17629396678891868 0.28851972545216953 1.5013799495172904 0.08562161459289723 0.20641190148557467 1.7511054592184647e-07 6.7566876980185135 0.5861428253557359 GPGCGFWAAGWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPGCGFWAAGWR 12 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 7016900.0 2630300.0 1880900.0 2505700.0 False True 3602792.9911847897 1797795.618695467 1913905.2665113793 1.0 0.4990005318357901 0.5312282085577128 21.780684329284583 -9.925233133288112 5.348321176900264 1.0000008658465134 0.5151143701938998 0.9966977936000134 0.013156893937342344 163466725987.07724 32890467011.353043 1813532.0868547666 0.004506597013538881 1.1878643996780675e-10 9.925233133288112 -0.48488649565261355 GPGGNEDGPQK(ub)LDSEADAEPQDLESTNLLESEAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPGGNEDGPQKLDSEADAEPQDLESTNLLESEAPR 35 1 Q96LD4;Q96LD4-2 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 24004600.0 9582500.0 9563300.0 4858800.0 True False 12562750.297061995 8136492.91745144 4356057.984900662 1.0 0.6476681240217194 0.3467439757932144 23.58264900468084 -7.519119270873426 0.23562181769866763 1.1508771548465437 7.621671189252265e-14 0.9998923189711619 0.0027702836836643904 0.1280246048334269 0.023461644444989348 0.029339213662872954 0.06676949009821108 3.02608225696312e-08 7.519119270873426 -1.1508771548464676 down GPGGNEDGPQK(ub)LDSEADAEPQDLESTNLLESEAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPGGNEDGPQKLDSEADAEPQDLESTNLLESEAPR 35 1 Q96LD4;Q96LD4-2 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 57602000.0 18808000.0 17391000.0 21403000.0 True False 18210950.334978685 24335316.992866915 15796912.223763192 1.0 1.3363013211960089 0.8674403001045624 24.11830287525701 -6.714175738661247 1.7801433401382118 1.2058628241846658 0.8683929830314523 0.4849549398710996 0.14162704074122337 0.36676174009518847 2.26801401681687 0.06324996358843746 0.15988687885515293 1.931186697966317e-07 6.714175738661247 -0.33746984115321355 GPGGNEDGPQK(ub)LDSEADAEPQDLESTNLLESEAPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPGGNEDGPQKLDSEADAEPQDLESTNLLESEAPR 35 1 Q96LD4;Q96LD4-2 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 184797000.0 45591000.0 39442000.0 99764000.0 True False 69164880.14855754 32403266.93824748 80045601.6718855 1.0 0.46849306857250816 1.1573156998169811 26.04353633072979 -6.700655899125865 1.8286191046315303 0.670162720494503 1.1552847656755794 0.4206220539686134 0.22432959746712353 0.3941751607788812 2.562977868390557 0.09785418537631184 0.2514433158610631 1.9922512173702518e-07 6.700655899125865 0.4851220451810764 GPGGNEDGPQK(ub)LDSEADAEPQDLESTNLLESEAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPGGNEDGPQKLDSEADAEPQDLESTNLLESEAPR 35 1 Q96LD4;Q96LD4-2 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 28633700.0 9582500.0 7252200.0 11799000.0 True False 13125409.20732549 6931773.824181648 9012319.208032776 1.0 0.5281186829826928 0.6866314844494801 23.64585906620373 -10.62910618420125 7.101724557374544 1.0009119943272722 0.6073750837160865 0.8910703229564703 0.06471258021545362 0.0009363915251549929 4.890381585786113e-05 0.06278924452958594 0.020885895455380277 2.3490584101735337e-11 10.62910618420125 -0.3935369106111857 GPGGNEDGPQK(ub)LDSEADAEPQDLESTNLLESEAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPGGNEDGPQKLDSEADAEPQDLESTNLLESEAPR 35 1 Q96LD4;Q96LD4-2 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 56353000.0 18808000.0 16982000.0 20563000.0 True False 15639685.33567455 16890514.595336907 24862628.227430277 1.0 1.079977904466478 1.5897140955079154 23.898708150691288 -6.934570497774748 0.7082692651882827 0.9934054064394651 1.7076819393335076 0.9973627950277711 0.013413167719562 0.09033295208161139 0.06655611792330465 0.012571250630251905 0.04501967079638088 1.1625978145242195e-07 6.934570497774748 0.7142765328940426 GPGGNEDGPQK(ub)LDSEADAEPQDLESTNLLESEAPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPGGNEDGPQKLDSEADAEPQDLESTNLLESEAPR 35 1 Q96LD4;Q96LD4-2 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 152289000.0 45591000.0 21891000.0 84807000.0 True False 59018448.232965045 20672746.60626445 69372996.19330367 1.0 0.35027601072570363 1.1754459541102447 25.81466265282224 -6.696750529102126 1.8423930045558674 0.5952749774870496 1.172854128352417 0.4022309085015491 0.2744220840053885 0.4023041576017848 2.6525457120680813 0.118930709986966 0.30709860204965533 2.0102472232469183e-07 6.696750529102126 0.5775791508653674 GPGGSSLLIEALSNSSHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPGGSSLLIEALSNSSHK 18 0 Q9BSH4 Q9BSH4 TACO1 Translational activator of cytochrome c oxidase 1 0 6811900.0 1706300.0 1576300.0 3529300.0 False True 1652134.4404813992 2205724.8102959073 2604870.453269516 1.0 1.3350758608077942 1.5766697851238478 20.655899658456896 -6.974674343113896 0.09406424136756793 0.34029731742894415 2.5775552114872573 0.9999998023210244 0.00010497109650176802 0.07481313085125309 0.0027507332801456354 0.02362793083666754 0.04142778941853107 1.0600483073065042e-07 6.974674343113896 2.237257894058313 GPGGSSLLIEALSNSSHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPGGSSLLIEALSNSSHK 18 0 Q9BSH4 Q9BSH4 TACO1 Translational activator of cytochrome c oxidase 1 0 5015700.0 1706300.0 1599200.0 1710200.0 False True 1418864.0519067158 1590584.792183654 2067794.912928626 1.0 1.1210269158952715 1.457359434929552 20.436304933891172 -6.953157291986199 0.5230354022885586 0.9944159682863175 1.599057776354691 0.9994263262344677 0.004634365022617187 0.08224217526063678 0.030903172096813546 0.005225134131920772 0.027789936767214897 1.1138910334964723e-07 6.953157291986199 0.6046418080683734 GPGTSFEFALAIVEALNGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPGTSFEFALAIVEALNGK 19 0 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 980420000.0 349200000.0 362260000.0 268960000.0 False True 529761929.9395991 297611872.6497016 215799938.11064443 1.0 0.5617841823470288 0.40735267280389303 28.980768930740048 -13.999999999999998 0.14534720158389489 3.1052563092823102 0.22801039455155658 0.9995825028925059 0.005129086527509521 11.943277274564071 0.11980897562044115 7.112811328082056 0.1609748915957577 1.0000000000000041e-14 13.999999999999998 -2.8772459147307536 GPGTSFEFALAIVEALNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPGTSFEFALAIVEALNGK 19 0 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 573316000.0 349200000.0 41956000.0 182160000.0 False True 452046283.7610793 39621111.71771187 149008749.11943814 1.0 0.08764835181933024 0.32963162063775303 28.751895252832497 -10.407955606870921 6.0185238334992786 1.0002163419857646 0.20863998622854138 0.9344687402822965 0.09878925581597957 0.00028685141485504487 2.821781078217414e-05 0.09567756687639228 0.031884095213292586 3.908808491831823e-11 10.407955606870921 -0.7915763557572232 GPGVDLPSVNLSMPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPGVDLPSVNLSMPK 15 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 20600800.0 2475500.0 12381000.0 5744300.0 False True 3245404.472776105 10533803.060760004 5149934.939216442 1.0 3.2457597039513026 1.5868391697911262 21.629966860955122 -6.5684948848605185 2.3108889638048686 2.5397479908548863 1.5900154449202404 0.0 0.978461382132299 0.7350901907071167 7.366036953280288 0.3580118486390279 1.0982884697032194 2.700878919207856e-07 6.5684948848605185 -0.949732545934646 GPGVDLPSVNLSMPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPGVDLPSVNLSMPK 15 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 15441800.0 6280300.0 2697700.0 6463800.0 False True 6080935.314162418 3774905.6783196526 4770736.870156549 1.0 0.6207771474772881 0.7845399800661529 22.5358618122898 -10.117745353818194 4.867486062548147 1.0000150970864792 0.7026585637699901 0.8146640625849519 0.06685589645189564 1.0953718759477134e-05 1.9852834500500607e-06 0.06473622894146926 0.021577647795312568 7.625259818901361e-11 10.117745353818194 -0.29735653331648904 GPGVDLPSVNLSMPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPGVDLPSVNLSMPK 15 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 16641800.0 2475500.0 7231600.0 6934700.0 False True 3390759.2478720904 6912084.00029674 5296866.684629624 1.0 2.038506273966368 1.5621476776783054 21.693176922478013 -10.12169481913124 4.7984258188228175 0.9999511925981145 1.80032697582828 0.7900755634607755 0.1944725826039169 0.00010161778853893798 1.8600029032012825e-05 0.1883087024343953 0.06276575614018061 7.556230211619259e-11 10.12169481913124 0.8003757832301656 GPGVDLPSVNLSMPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPGVDLPSVNLSMPK 15 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 10438400.0 6280300.0 2073700.0 2084400.0 False True 5222347.714463898 2062528.566502779 2520238.4028233085 1.0 0.39494278804729277 0.4825872463151421 22.316267087724075 -10.735805819132318 6.949192883795335 1.0081885765240062 0.43876501718121746 0.9820382302668962 0.03578070025648088 0.004527786195959758 0.00017213697076874125 0.03455627371417581 0.011548171350749158 1.8373596762492476e-11 10.735805819132318 -0.5694235593427888 GPGVDVNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPGVDVNLK 9 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5941900.0 2340500.0 1402400.0 2199000.0 False True 3068418.1654342436 1193167.3865123854 1971468.5742974705 1.0 0.38885423113232287 0.642503227397778 21.549063676704915 -10.337492638174213 5.814797057742294 1.0000680436629759 0.5156787292650706 0.8293851821994839 0.1035517691032519 9.135706410928576e-05 1.0408913467286315e-05 0.10027757196488919 0.03342118976726678 4.597347815349867e-11 10.337492638174213 -0.4843893143979052 GPGVDVNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPGVDVNLK 9 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 4152950.0 1574500.0 768550.0 1809900.0 False True 1524518.359337728 1075436.0229353036 1335832.8941638547 1.0 0.7054267443538613 0.8762327367078472 20.539922093739403 -10.21096310223563 5.244567903306891 1.0000152174467796 0.7908297410544948 0.6666167255386211 0.06973125437971513 1.2408350790096937e-05 1.8668074612421057e-06 0.06752190639181398 0.02250566557686791 6.152291405062833e-11 10.21096310223563 -0.2091854763922848 GPGVDVNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPGVDVNLK 9 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5305810.0 2340500.0 866910.0 2098400.0 False True 3205846.0996342655 828607.0497119913 1602801.1379045667 1.0 0.25846750716028505 0.499961972000908 21.612273738227806 -10.197940806671244 5.372349207432305 1.000030478902526 0.379214739581864 0.8980697895952862 0.09858970242806404 3.599294704358434e-05 5.373557641615381e-06 0.0954637421057455 0.03181968963422941 6.339561121136941e-11 10.197940806671244 -0.620815739320662 GPGVDVNLK(ub)GPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPGVDVNLKGPR 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 2815590.0 1103600.0 581090.0 1130900.0 True False 1068566.8220800979 813122.2673443177 834683.3637272252 1.0 0.760946578672052 0.7811241622703674 20.0272456980699 -10.691882301721604 6.685558539563412 1.0019944790954438 0.7710353704712097 0.9942091707838341 0.008237464009703965 0.00024678626255730167 1.1373635064982294e-05 0.008037807198057275 0.002658630077047198 2.0329078752636993e-11 10.691882301721604 -0.23095910862423408 GPIFALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPIFALK 7 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3;O60907;O60907-2;Q9BQ87;A0A2R8YFW3 Q9BZK7 TBL1XR1;TBL1X;TBL1Y F-box-like/WD repeat-containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1X;F-box-like/WD repeat-containing protein TBL1Y 0 6501200.0 1105500.0 1994700.0 3401000.0 False True 1449321.2056772292 1697098.5352797033 3049097.1446956345 1.0 1.1709609496030897 2.103810482280822 20.466945936809186 -6.937877220166732 0.679031564257779 0.9890450770502174 2.340396355544023 0.9978723449508259 0.02237562858899818 0.08874864607005689 0.059122152477137195 0.021445369941279227 0.0810680850142783 1.1537793978605031e-07 6.937877220166732 1.3513512784938055 up GPIFALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPIFALK 7 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3;O60907;O60907-2;Q9BQ87;A0A2R8YFW3 Q9BZK7 TBL1XR1;TBL1X;TBL1Y F-box-like/WD repeat-containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1X;F-box-like/WD repeat-containing protein TBL1Y 0 4612740.0 1931800.0 742340.0 1938600.0 False True 1870476.0664138584 1038760.233251959 1430822.5032466166 1.0 0.5553453753853724 0.764950981698386 20.834974075396318 -10.05548797149812 4.917394760353336 1.0000077046166969 0.6601481785387475 0.7780340115283736 0.08557113045975805 7.228116720818463e-06 1.388238972266396e-06 0.0828557692591402 0.027617963597353554 8.80059486048566e-11 10.05548797149812 -0.33985952607794934 GPIFALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPIFALK 7 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3;O60907;O60907-2;Q9BQ87;A0A2R8YFW3 Q9BZK7 TBL1XR1;TBL1X;TBL1Y F-box-like/WD repeat-containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1X;F-box-like/WD repeat-containing protein TBL1Y 0 7121200.0 1105500.0 3148900.0 2866800.0 False True 1514233.225014176 3009771.185980199 2189720.88359932 1.0 1.9876536429531997 1.4460922184419909 20.530155998332077 -10.183774342632502 5.731616880596265 0.9999849664597015 1.716872930697614 0.7002663018684403 0.22109152573796453 4.248259393350036e-05 6.0499034957555025e-06 0.21407543217785305 0.07135698309754747 6.549764083247326e-11 10.183774342632502 0.7168879642379126 GPILMELQTYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPILMELQTYR 11 0 P08559;P08559-4;P08559-3;P08559-2;P29803 P08559 PDHA1;PDHA2 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial;Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial 0 6785400.0 2153100.0 1212900.0 3419400.0 False True 2084751.019047353 1697217.2951899436 2523756.5601988444 1.0 0.8141103084652782 1.2105793627826593 20.991443662809665 -6.7792138670520945 1.5390344747899627 0.8946383584086403 1.2136379006671094 0.7645813916075889 0.07858408184416628 0.25178851722288453 1.1779564231081057 0.040219653802283366 0.09496005228669722 1.6625937093167377e-07 6.7792138670520945 0.31899954225846916 GPILMELQTYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPILMELQTYR 11 0 P08559;P08559-4;P08559-3;P08559-2;P29803 P08559 PDHA1;PDHA2 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial;Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial 0 4765900.0 2153100.0 1274300.0 1338500.0 False True 1790398.048502812 1267435.0929712525 1618374.1614752454 1.0 0.7079068780437525 0.9039186357629141 20.77184893824394 -10.272995689754904 4.879492885331884 1.0000550279454687 0.8059127569031524 0.5665891476537699 0.08002146500030728 4.791704834584998e-05 7.139328246620324e-06 0.0775023872265049 0.025826816773684234 5.3334018870598145e-11 10.272995689754904 -0.1941422710423163 GPILSFASTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPILSFASTR 10 0 P40937;P40937-2;F5H5S0;E9PEP3;C9JH72 P40937 RFC5 Replication factor C subunit 5 0 10823400.0 3278200.0 2541000.0 5004200.0 False True 4297751.946133963 2161892.7047404223 4486413.387675946 1.0 0.5030287303307838 1.0438977037080264 22.035150786289567 -6.665120121046482 1.9548079453545781 0.6814611712600673 1.0416646828942255 0.25755509153070666 0.21134341295241102 0.47242228333166886 3.475520835449152 0.0871886137868689 0.23442697724845454 2.162120422440433e-07 6.665120121046482 0.3602035116341582 GPLDK(ub)WR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPLDKWR 7 1 F8W7C6;P27635;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 3401630.0 1259700.0 1235300.0 906630.0 True False 1651478.8989521512 1050998.0551616861 812820.6246090579 1.0 0.6363981131266861 0.49217742056818614 20.65532710566177 -13.999999999999996 0.12764998505119687 2.7277763821365077 0.28404628205601024 0.9996563808565798 0.003960769722412768 11.940976061500074 0.11086694774998747 5.187892069089765 0.18495123384654982 1.0000000000000082e-14 13.999999999999996 -2.4437301000804976 GPLDK(ub)WR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPLDKWR 7 1 F8W7C6;P27635;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 11049500.0 3664000.0 5314300.0 2071200.0 True False 3046778.342721798 5285670.811094035 2504278.343853212 1.0 1.7348393012312648 0.8219430697462714 21.53885311513521 -6.692455438194287 1.8573879817015688 1.4596463902852312 0.824983066660714 0.3819197062327827 0.31063513508323615 0.41150153798106237 2.754217449594654 0.1336877191420833 0.3470972907508309 2.0302268253662032e-07 6.692455438194287 -0.6346633236245173 GPLDK(ub)WR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPLDKWR 7 1 F8W7C6;P27635;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 12046500.0 4097200.0 3488000.0 4461300.0 True False 5303906.167886292 3293889.733801581 3649389.176803635 1.0 0.6210309212755661 0.6880568888830827 22.338623822089428 -10.71047555297531 6.810178578150483 1.0036870554719464 0.6545439050793315 0.9725419253760663 0.02736323669245489 0.0015430105950328776 6.559867918393467e-05 0.02668790713070647 0.00883144666735079 1.9477106861295328e-11 10.71047555297531 -0.3491431503926149 GPLEPGPPK(ub)PGVPQEPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPLEPGPPKPGVPQEPGR 18 1 Q9BYM8-3;Q9BYM8;G3XAG9;H0Y4S7;B4DML5;Q9BYM8-4 Q9BYM8-3 RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1 1 16133000.0 8843900.0 3877500.0 3411600.0 True False 8563155.2354061 5425805.970895375 2517999.6141938292 1.0 0.6336222831114028 0.29405044577291434 23.029711048629654 -7.52035829906645 0.2808937979899441 1.1046671984974394 3.755833515283335e-14 0.9997648865351331 0.004420188205279981 0.12567196645510953 0.02956233948817358 0.025256484571098765 0.06651688429945814 3.0174612451636994e-08 7.52035829906645 -1.104667198497402 down GPLEPGPPK(ub)PGVPQEPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPLEPGPPKPGVPQEPGR 18 1 Q9BYM8-3;Q9BYM8;G3XAG9;H0Y4S7;B4DML5;Q9BYM8-4 Q9BYM8-3 RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1 1 45410300.0 9713500.0 26817000.0 8879800.0 True False 14736089.651971065 22031296.827822678 7124703.637845407 1.0 1.4950571927930572 0.48348671907627977 23.812850407901944 -6.773651707122207 1.5606453232449002 1.282630666629638 0.47701948911591624 0.7442529795893478 0.20886149019543584 0.260575896672464 1.2530248693304966 0.10546067235920878 0.25019132821903295 1.6840240631593285e-07 6.773651707122207 -0.8056111775137218 down GPLEPGPPK(ub)PGVPQEPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPLEPGPPKPGVPQEPGR 18 1 Q9BYM8-3;Q9BYM8;G3XAG9;H0Y4S7;B4DML5;Q9BYM8-4 Q9BYM8-3 RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1 1 8029700.0 4101100.0 3928600.0 0.0 True False 5617387.498060281 3755021.4618570926 0.0 1.0 0.6684640258756805 0.0 22.42146789551782 -7.493955093749445 0.7179132620716785 0.9929046270293476 4.538125960400339e-17 0.9870999041342273 0.047237410135355665 0.11873430221237283 0.1421393527642732 0.04165985339237639 0.07541290636037798 3.206600871379228e-08 7.493955093749445 -0.9929046270293476 down GPLEPGPPK(ub)PGVPQEPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPLEPGPPKPGVPQEPGR 18 1 Q9BYM8-3;Q9BYM8;G3XAG9;H0Y4S7;B4DML5;Q9BYM8-4 Q9BYM8-3 RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1 1 16070200.0 8843900.0 5713400.0 1512900.0 True False 7354094.701200135 5682620.780178887 1829240.395140751 1.0 0.7727152030353273 0.2487376719315611 22.81011632406393 -6.9820530264922365 0.48118292824783077 1.0124024807892404 5.867689068492586e-11 0.9996511557739108 0.00587539532649082 0.07714207032753687 0.025160397361764376 0.007266236818457119 0.041185585761763954 1.0421901722778843e-07 6.9820530264922365 -1.0124024807305636 down GPLEPGPPK(ub)PGVPQEPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPLEPGPPKPGVPQEPGR 18 1 Q9BYM8-3;Q9BYM8;G3XAG9;H0Y4S7;B4DML5;Q9BYM8-4 Q9BYM8-3 RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1 1 37550000.0 9713500.0 20697000.0 7139500.0 True False 12574317.23171032 19545193.755874805 5840184.257456244 1.0 1.554374157714512 0.4644533893839006 23.583976729994394 -6.768429310640044 1.5804020132344594 1.3186143526204734 0.45867457263939976 0.7245304265498748 0.23354884231274803 0.2689813870202968 1.325623976807508 0.11649731141284031 0.2777206859005593 1.7043967184382728e-07 6.768429310640044 -0.8599397799810737 down GPLINSEFYTGWLDHWGQPHSTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPLINSEFYTGWLDHWGQPHSTIK 24 0 E7EQ29;P16278-2;P16278-3;P16278;C9J4G9 E7EQ29 GLB1 Beta-galactosidase 0 10283000.0 3588100.0 2041800.0 4653100.0 False True 3474197.729526645 2857101.38784634 3434313.519992178 1.0 0.8223773113327134 0.9885198792240586 21.728248434854827 -10.496863589829307 7.352245686727547 1.0000189010305405 0.9054485952845774 0.301593093761484 0.06782741931491797 2.101836849217505e-05 1.4384304768461447e-06 0.06568673776909029 0.021891205451908705 3.185197822599374e-11 10.496863589829307 -0.09457030574596303 GPLMMYISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPLMMYISK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 99807000.0 26598000.0 34452000.0 38757000.0 False True 34870235.57539838 29311895.892844167 34746797.42339569 1.0 0.840599307953178 0.9964600711762964 25.05549277487938 -10.713447929497292 8.039068157352066 1.0004049372654598 0.9185296895661752 0.26702550322423013 0.06362989013623101 0.0004640726481940547 1.6541842491412117e-05 0.06191219824306903 0.020536458734885858 1.934425776105361e-11 10.713447929497292 -0.08187524769928456 GPLMMYISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPLMMYISK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 37891500.0 15991000.0 5117500.0 16783000.0 False True 15483374.458030872 7160944.437409946 12387028.82079231 1.0 0.46249249198360165 0.8000212650264646 23.88421659198109 -10.658142813789858 5.180407934959031 1.0062483341201027 0.631256878505067 0.6141003662402562 0.13779554457711662 0.010056641062169887 0.0006636409351463446 0.134930041870596 0.044473320777395825 2.1971372453795042e-11 10.658142813789858 -0.3749914556150358 GPLMMYISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPLMMYISK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 100361000.0 21957000.0 44117000.0 34287000.0 False True 33310374.271717597 36243976.66230576 27510159.421474025 1.0 1.0880687309802748 0.8258736211448611 24.989468228278362 -6.816145322854422 1.3887302344958092 1.0476607667511066 0.8206213283111419 0.8752215672783679 0.0384839475863082 0.19854393541780074 0.7534455970389801 0.021783362526400764 0.050259719061415825 1.527054992285597e-07 6.816145322854422 -0.22703943843996477 GPLMMYISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPLMMYISK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 94676000.0 26598000.0 40159000.0 27919000.0 False True 36431999.38392313 38384642.591945976 21325107.209853984 1.0 1.05359692690609 0.5853400189522516 25.11870283640227 -6.8784193600129235 1.0885243693884927 1.0325762812678383 0.5531378209950975 0.9723902648403937 0.03476979190194972 0.12904189868207813 0.28079591550703237 0.024638826206632842 0.05935352348025202 1.3230633521785544e-07 6.8784193600129235 -0.47943846027274084 GPLMMYISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPLMMYISK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 47513000.0 15991000.0 16536000.0 14986000.0 False True 13297225.02141494 16446917.285860987 18119503.31256483 1.0 1.236868388658049 1.3626529808575625 23.664621867415367 -12.708834330440062 0.08901382785188237 1.85187242800579e-15 1.704943942009403 0.9998788970569331 0.0016545411829528309 7.72078134034383 0.0740329849264017 1.6822324029771596 0.27598522649303914 1.9550851164591304e-13 12.708834330440062 1.7049439420094012 GPLMMYISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPLMMYISK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 95882000.0 21957000.0 41809000.0 32116000.0 False True 28423769.337176472 39482292.39693531 26271217.537987918 1.0 1.389058992443166 0.9242693052545584 24.76059455037081 -6.68461960277935 1.8852907135112995 1.245128989124204 0.9259603817064874 0.34549387071073134 0.16472767014943754 0.4283281785206277 2.9472168926099465 0.07000719463566171 0.1835660884540755 2.0671900085368032e-07 6.68461960277935 -0.3191686074177167 GPLQSVQVFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPLQSVQVFGR 11 0 P62249;M0R210;M0R3H0;Q6IPX4 P62249 RPS16 40S ribosomal protein S16 0 39259000.0 10106000.0 15098000.0 14055000.0 False True 13249063.866643224 12845437.25154307 12600723.425080027 1.0 0.9695354615871123 0.9510651885983051 23.659387091610913 -13.999999999990543 0.04936536229571421 1.2221262015480443 0.8420270941820976 0.9999765767128461 9.747907542609706e-05 12.570647367998834 0.052656070546084885 0.38347927437359286 0.10454525775873648 1.0000000000217763e-14 13.999999999990543 -0.38009910736594665 GPLQSVQVFGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPLQSVQVFGR 11 0 P62249;M0R210;M0R3H0;Q6IPX4 P62249 RPS16 40S ribosomal protein S16 0 28460700.0 9590100.0 4237600.0 14633000.0 False True 9285667.52485534 5929695.77879207 10800178.319409754 1.0 0.6385858381123168 1.163101983836968 23.14657419517496 -6.721248068051708 1.7543971179266253 0.7804260692316763 1.1623686136943343 0.5186617935091287 0.1520605095493192 0.3528637565938531 2.1231371564189208 0.0687964641497219 0.17247973734491928 1.8999926982665916e-07 6.721248068051708 0.38194254446265796 GPLQSVQVFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPLQSVQVFGR 11 0 P62249;M0R210;M0R3H0;Q6IPX4 P62249 RPS16 40S ribosomal protein S16 0 34597000.0 10106000.0 11540000.0 12951000.0 False True 13842461.304381067 11030124.642323172 9892240.534217527 1.0 0.7968326152251691 0.7146301742658067 23.722597153133805 -13.999999999997426 0.12460742895994946 1.9659778870492892 0.5912199169286705 0.9996706650601437 0.002176611767918847 11.948438797546123 0.10920492237344437 2.8422104196032274 0.10958132614829773 1.0000000000059267e-14 13.999999999997426 -1.3747579701206187 GPLQSVQVFGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPLQSVQVFGR 11 0 P62249;M0R210;M0R3H0;Q6IPX4 P62249 RPS16 40S ribosomal protein S16 0 18534000.0 9590100.0 4453200.0 4490700.0 False True 7974593.063465156 4429209.727709006 5429684.607349185 1.0 0.5554151406171446 0.6808729378587068 22.926979470609236 -10.424953187223277 8.921060074741161 1.0000028305603041 0.6181440392379304 0.9251056956624318 0.05121793124922974 2.8834628060076974e-06 1.8588339808685961e-07 0.04959191579126085 0.01653051622962193 3.75877918136743e-11 10.424953187223277 -0.38185879132237377 GPLQSVQVFGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPLQSVQVFGR 11 0 P62249;M0R210;M0R3H0;Q6IPX4 P62249 RPS16 40S ribosomal protein S16 0 18210300.0 4431200.0 7209900.0 6569200.0 False True 5736275.752010584 6808662.726988532 5373673.0056840945 1.0 1.186948295608361 0.9367877762502271 22.451682947704292 -6.7066817467717 1.8071452962542882 1.1153213289810269 0.9374343669707986 0.44924976334427114 0.07882140356745292 0.38179989800848535 2.428462895601883 0.0347380250546522 0.08860412954330867 1.9647995646315094e-07 6.7066817467717 -0.17788696201022824 GPLVNASLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPLVNASLR 9 0 O14744-2;O14744;O14744-3;O14744-5;O14744-4;H0YJX6;H0YJ77 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 6916000.0 1814600.0 2391400.0 2710000.0 False True 2378958.1726113986 2034612.441604189 2429595.1961555905 1.0 0.8552535580609982 1.021285377829324 21.18189847551488 -6.676319403636794 1.915199225979711 0.9081135099247946 1.0206324502196604 0.307207279255425 0.06139749045170364 0.4467828989720185 3.165220448703645 0.02575554898504287 0.06824464853954673 2.1070779209456937e-07 6.676319403636794 0.11251894029486587 GPLVNASLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPLVNASLR 9 0 O14744-2;O14744;O14744-3;O14744-5;O14744-4;H0YJX6;H0YJ77 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 10517900.0 1854200.0 6459800.0 2203900.0 False True 2812956.9601775603 5306998.21935223 1768298.1989963136 1.0 1.8866261711367387 0.6286261126742211 21.423656048100703 -6.717275727329961 1.768760918495022 1.5409499234460153 0.6308281041121714 0.4998545160194693 0.3732230503272866 0.36060598336501526 2.2032119574924383 0.16762880778531725 0.42222219196398036 1.917450992045961e-07 6.717275727329961 -0.910121819333844 GPLVNASLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPLVNASLR 9 0 O14744-2;O14744;O14744-3;O14744-5;O14744-4;H0YJX6;H0YJ77 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 7140000.0 1814600.0 1812600.0 3512800.0 False True 2485506.657721144 1732513.3385333614 2683148.9883869467 1.0 0.6970463479352856 1.0795179244649509 21.245108537037773 -6.695605606763997 1.846337796318453 0.811070837704905 1.078296760820552 0.39675675943741673 0.12798685875608323 0.40478319661302414 2.67946277251617 0.05536457634922195 0.14317129568946224 2.0155537917545793e-07 6.695605606763997 0.2672259231156471 GPLVNASLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPLVNASLR 9 0 O14744-2;O14744;O14744-3;O14744-5;O14744-4;H0YJX6;H0YJ77 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 3147310.0 862890.0 1462300.0 822120.0 False True 717531.2675085181 1454422.2996561755 994021.4909466035 1.0 2.026981074575833 1.38533543548303 19.452682175209958 -10.150329718503786 4.898225993174037 0.9999513578591198 1.706158255031872 0.6175798353611544 0.26195073525168355 0.0001391602586415918 2.413865045290377e-05 0.2536500998987346 0.08454423626184099 7.074085124429705e-11 10.150329718503786 0.7062068971727521 GPLVNASLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPLVNASLR 9 0 O14744-2;O14744;O14744-3;O14744-5;O14744-4;H0YJX6;H0YJ77 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 6317000.0 1854200.0 2304000.0 2158800.0 False True 2400298.4517462566 2175780.3746212292 1765920.5511585583 1.0 0.9064624330521537 0.7357087406667375 21.194782370193153 -6.961790353236293 0.4094245849158746 1.0084644173387554 0.6273758889990276 0.9998309342030798 0.0014227340242233713 0.07906770863768363 0.018813450702604182 0.0021984298270119338 0.014259312834361259 1.0919673340991617e-07 6.961790353236293 -0.38108852833972773 GPNGASAGVAAQHSQCFAAWYGHCPGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPNGASAGVAAQHSQCFAAWYGHCPGLK 28 0 P11177-2;P11177;C9J634;F8WF02 P11177-2 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 61400900.0 19855300.0 24402600.0 17143000.0 False True 26030490.57899874 20761827.200589795 15369206.807267634 1.0 0.7975964624093687 0.5904309317807259 24.63369916570459 -6.970834722036852 0.23740643646730922 1.0768213787840373 0.3052332062630764 0.9999881794176185 0.0005748557031876544 0.07603279282569617 0.008054764775704592 0.005044284826135417 0.020291060266212208 1.0694618032015387e-07 6.970834722036852 -0.7715881725209609 GPNGASAGVAAQHSQCFAAWYGHCPGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPNGASAGVAAQHSQCFAAWYGHCPGLK 28 0 P11177-2;P11177;C9J634;F8WF02 P11177-2 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 86204800.0 15226000.0 39914800.0 31064000.0 False True 23098955.16970316 32791692.084244203 24924186.784165148 1.0 1.4196179802649318 1.07901792964454 24.461324260200115 -10.132771303069854 5.900695760716787 0.9999980967279982 1.2493179549547433 0.416713939910194 0.13904938839770667 3.4815360535265613e-06 5.115292012121579e-07 0.13463501848328716 0.044877997130383214 7.365948819332455e-11 10.132771303069854 0.24931985822674507 GPNGASAGVAAQHSQCFAAWYGHCPGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPNGASAGVAAQHSQCFAAWYGHCPGLK 28 0 P11177-2;P11177;C9J634;F8WF02 P11177-2 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 65364300.0 19855300.0 17739700.0 27769300.0 False True 27196340.97930709 16955901.396656908 21210763.2666857 1.0 0.6234625977648304 0.7799123890535258 24.696909227227483 -10.141378023541723 5.230230339672109 1.000009635643999 0.7016874947788566 0.8289912713246496 0.0638703598378067 7.176580741799604e-06 1.1781787786653032e-06 0.06184420658150046 0.020614069997230994 7.221409558145263e-11 10.141378023541723 -0.2983221408651423 GPNGASAGVAAQHSQCFAAWYGHCPGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPNGASAGVAAQHSQCFAAWYGHCPGLK 28 0 P11177-2;P11177;C9J634;F8WF02 P11177-2 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 107353900.0 15226000.0 47528000.0 44599900.0 False True 19710357.149330467 44883025.019530274 36483175.83361899 1.0 2.277128957100348 1.8509647266771254 24.232450582292564 -10.12050437813645 4.820588094913516 0.9999387262285566 2.0640468418962987 0.8926118396092646 0.17398081855317998 60675773.006676905 4.978990912747551 41267.22782384515 0.05955826180531362 7.576970944589126e-11 10.12050437813645 1.064108115667742 GPNGYGFHLHGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPNGYGFHLHGEK 13 0 O14745;J3QRP6 O14745 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 0 34791800.0 10048000.0 7626800.0 17117000.0 False True 13173025.304970408 6488911.1690335525 15345897.037858035 1.0 0.4925908072601345 1.1649485735116416 23.651083375884586 -6.704812943103726 1.8136145085428714 0.6864260348300829 1.1631486598681962 0.4405566217470428 0.21399965848630575 0.3855564198288823 2.468673674645291 0.09401704046880846 0.24036907934443488 1.9732724700145986e-07 6.704812943103726 0.47672262503811325 GPNGYGFHLHGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPNGYGFHLHGEK 13 0 O14745;J3QRP6 O14745 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 0 15656400.0 3819300.0 1936000.0 9901100.0 False True 3698058.412079125 2709054.8961066264 7307704.883366902 1.0 0.7325614131074635 1.97609233523663 21.818336582100716 -6.850431325890965 1.2330092487585982 0.8572328972629002 2.0262192356831914 0.9409331763883195 0.12988886655452017 0.15698043776715084 0.45904401922372323 0.08242204943460527 0.19078260016939505 1.4111353588001126e-07 6.850431325890965 1.1689863384202912 GPNGYGFHLHGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPNGYGFHLHGEK 13 0 O14745;J3QRP6 O14745 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 0 21145300.0 10048000.0 5171400.0 5925900.0 False True 13763017.136989983 4942910.448467076 4526324.467741462 1.0 0.3591443939412333 0.3288758869286262 23.714293437407477 -13.565951673796807 0.43931097739011327 9.999758246979246 0.32856632274991426 0.9998807887092435 0.00337905603213964 22.422228677613433 0.2234683068583384 192.36562665927318 0.007006779281641104 2.716741557966957e-14 13.565951673796807 -9.671191924229332 GPNGYGFHLHGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPNGYGFHLHGEK 13 0 O14745;J3QRP6 O14745 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 0 9930500.0 3819300.0 4389200.0 1722000.0 False True 3175917.1736783227 4365554.508412014 2082062.2383715876 1.0 1.3745807178453153 0.6555782548825602 21.598741857534993 -6.7651297097316325 1.5930181159285044 1.2161884651552888 0.652252727004989 0.7115710016191836 0.15768904686555013 0.274402502556412 1.373455199853887 0.0780592271899131 0.18666177093688122 1.7173953800334204e-07 6.7651297097316325 -0.5639357381502997 GPNGYGFHLHGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPNGYGFHLHGEK 13 0 O14745;J3QRP6 O14745 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 0 19866400.0 6258800.0 7601300.0 6006300.0 False True 8102139.97939246 7178280.972920285 4913215.029842352 1.0 0.8859734577751086 0.6064095464085983 22.949871579778147 -6.955878173477189 0.4900857544664562 1.0061132925914704 0.4744132618078015 0.9995854616285775 0.0033665968619804054 0.0812077713557068 0.02683230923644991 0.00402587440775207 0.02305759082283314 1.1069342531272512e-07 6.955878173477189 -0.5317000307836689 GPNK(ub)HTLTQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPNKHTLTQIK 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 2390320.0 694940.0 848390.0 846990.0 True False 911073.0698085341 721813.5189983192 759351.5997017798 1.0 0.7922674293841342 0.8334694821583968 19.797207240015133 -10.481040834776634 6.116823329551904 1.0001252464637 0.8128684557712661 0.9649171360791533 0.016820667608694613 2.8749197898025568e-05 2.4390952941888216e-06 0.0162973911559015 0.005428847126713729 3.303384793200123e-11 10.481040834776634 -0.18725679069243395 GPNK(ub)HTLTQIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPNKHTLTQIK 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 19499510.0 704910.0 2568600.0 16226000.0 True False 1069400.0058239496 2110213.261436602 13018923.98789157 1.0 1.973268421492787 12.174045181401295 20.028370159030256 -6.9254418012308365 0.7833122100811499 0.8159052469189747 14.044162814460687 0.995563812763939 0.33660272859253876 0.09507483916345902 0.08979103808193262 0.2987174776456784 0.9471795774472066 1.187293796797278e-07 6.9254418012308365 13.228257567541712 up GPNK(ub)HTLTQIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPNKHTLTQIK 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 3122040.0 694940.0 761100.0 1666000.0 True False 951878.0980473562 727472.085378871 1272525.1123470317 1.0 0.764249210976886 1.336857224635631 19.860417301538025 -6.794878575881544 1.4765541576985928 0.8690727608376253 1.343814638355048 0.8168361444985194 0.10056497470468252 0.2281381126742979 0.9823839863507712 0.05359272051385268 0.12505538283061496 1.6036937037197602e-07 6.794878575881544 0.4747418775174227 GPNK(ub)HTLTQIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPNKHTLTQIK 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 4870790.0 493590.0 2093900.0 2283300.0 True False 410441.9547445561 2082619.745093391 2760727.473213619 1.0 5.074090796564733 6.726231179100084 18.646818682984783 -8.944393944740803 0.3723121399099513 5.909676081099349e-18 7.126634516909006 0.9977758773184549 0.11348799717372424 0.42594344181063937 0.1318297690260707 1.1093118585087125 0.44443322892024817 1.1365958219105734e-09 8.944393944740803 7.126634516909006 GPNK(ub)HTLTQIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPNKHTLTQIK 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 15425810.0 704910.0 3347900.0 11373000.0 True False 912519.8908534443 3161586.4219593788 9303230.696834499 1.0 3.464676719542486 10.195099076836067 19.799496481122706 -6.953543561399724 0.5184860987016434 0.8842798446884268 13.075075008730964 0.9994508193354396 0.09107159456343647 0.08209330076091391 0.030309517023579237 0.10342287575660075 0.55585547272899 1.1129007589951059e-07 6.953543561399724 12.190795164042537 GPNSALVQQLIK(ub)DLPDEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPNSALVQQLIKDLPDEVR 19 1 H7BXH2;E9PKF6;Q5H9R7-3;Q5H9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7;Q5H9R7-5;E9PQP7;H0YEN2;H0YDW1 H7BXH2 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 14067100.0 2803100.0 6281000.0 4983000.0 True False 4252507.634059822 5160106.47632301 3998107.8658735147 1.0 1.2134267402588326 0.9401765287500649 22.019882395127087 -6.698298379391171 1.8367501203308625 1.1327487026194198 0.9410099778769027 0.40957590925246223 0.09011834500998529 0.3990810593177167 2.616270183985148 0.039158376093820196 0.10092411212412394 2.003095339986046e-07 6.698298379391171 -0.19173872474251719 GPNSALVQQLIK(ub)DLPDEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPNSALVQQLIKDLPDEVR 19 1 H7BXH2;E9PKF6;Q5H9R7-3;Q5H9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7;Q5H9R7-5;E9PQP7;H0YEN2;H0YDW1 H7BXH2 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 9570100.0 3014900.0 3277900.0 3277300.0 True False 2507022.932716144 3260241.3020877955 3962568.277476888 1.0 1.3004433503747828 1.5805871680574481 21.257543762450368 -6.9719674793438395 0.20583853767402113 0.8453124799328802 2.0435023820712575 0.9999939337988623 0.0005838717283341673 0.0756693190766049 0.0066947430925419875 0.008672987022523716 0.029315810668486996 1.0666759926214103e-07 6.9719674793438395 1.1981899021383773 GPPHSK(ub)SGGGTGEEPGSQGLNGEAGPEDSTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPPHSKSGGGTGEEPGSQGLNGEAGPEDSTR 31 1 O15355 O15355 PPM1G Protein phosphatase 1G 1 18437400.0 4673400.0 5813900.0 7950100.0 True False 4525045.475089821 8135420.589087981 5867730.312112315 1.0 1.797864935031729 1.296722948844142 22.109500860162427 -10.386570103434044 5.068015783039434 0.9995740601807919 1.5472939419379872 0.6139330769605182 0.20459035914092683 0.0009853715494933005 0.00011926861468105832 0.19824297037326577 0.06603125447892456 4.106103541621407e-11 10.386570103434044 0.5477198817571953 GPPHSK(ub)SGGGTGEEPGSQGLNGEAGPEDSTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPPHSKSGGGTGEEPGSQGLNGEAGPEDSTR 31 1 O15355 O15355 PPM1G Protein phosphatase 1G 1 27394400.0 7140500.0 7242900.0 13011000.0 True False 10832660.540474549 5950347.9059640085 10439370.147076124 1.0 0.5492969971440959 0.9636940166334064 23.368884281779568 -10.454517472221445 8.855387953482225 1.0000035978874526 0.7564955068887511 0.31524820756041017 0.16917687477983115 1.201714542073518e-05 7.402478339336367e-07 0.16380722392483985 0.05460160154880866 3.5114179734932633e-11 10.454517472221445 -0.24350809099870152 GPPHSK(ub)SGGGTGEEPGSQGLNGEAGPEDSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPPHSKSGGGTGEEPGSQGLNGEAGPEDSTR 31 1 O15355 O15355 PPM1G Protein phosphatase 1G 1 12742100.0 5184100.0 3408400.0 4149600.0 True False 7100801.865034818 3257805.6179284477 3169549.9436946223 1.0 0.4587940460598211 0.4463650731196794 22.75955052089751 GPPHSK(ub)SGGGTGEEPGSQGLNGEAGPEDSTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPPHSKSGGGTGEEPGSQGLNGEAGPEDSTR 31 1 O15355 O15355 PPM1G Protein phosphatase 1G 1 15100400.0 4673400.0 7304500.0 3122500.0 True False 3886139.16672381 7265149.2086702725 3775400.31319122 1.0 1.869503097284887 0.971504146202271 21.889906135596704 -6.653556325351201 1.9961231048835637 1.562644940700872 0.9753018175981928 0.20844416071122707 0.3707948639964258 0.4999045931327433 3.8220318927525487 0.15045179620826127 0.41072099794597916 2.2204636841491135e-07 6.653556325351201 -0.5873431231026792 GPPHSK(ub)SGGGTGEEPGSQGLNGEAGPEDSTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPPHSKSGGGTGEEPGSQGLNGEAGPEDSTR 31 1 O15355 O15355 PPM1G Protein phosphatase 1G 1 31032900.0 7140500.0 8659400.0 15233000.0 True False 9243518.010297798 8177496.7777756285 12460750.303779101 1.0 0.8846736457553757 1.348052796553988 23.140010603872017 -6.840820049070482 1.2785962890462237 0.9386549131919921 1.3635414817758489 0.9258542894106432 0.0536333246714648 0.16784168650185285 0.5326510668927673 0.03288762091122438 0.07578349220314946 1.4427130191916425e-07 6.840820049070482 0.42488656858385676 GPPQEEEEEEDEEEEATK(ub)EDAEAPGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPPQEEEEEEDEEEEATKEDAEAPGIR 27 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 6094200.0 1508800.0 2095500.0 2489900.0 True False 1460903.9698753646 2932244.077888139 1837720.4946011314 1.0 2.007143616796592 1.2579338084473235 20.478429917391725 -10.145336190138314 4.535177469974266 0.9999345458224416 1.6325387124604902 0.4872844406195953 0.305863623695832 213863198.29726002 31.070165627632026 187918.04391602663 0.10470525384895749 7.155892535308881e-11 10.145336190138314 0.6326041666380486 GPPQEEEEEEDEEEEATKEDAEAPGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPPQEEEEEEDEEEEATKEDAEAPGIR 27 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 0 17465400.0 4661400.0 1868000.0 10936000.0 False True 4513426.40852136 2613902.141491313 8071533.527032388 1.0 0.5791391960122048 1.788338347955184 22.105791653746195 -6.81269498441011 1.4031877140164861 0.7713545166312586 1.8108196132515229 0.8667437784719333 0.1829574436448103 0.2031490861189785 0.7878153949483774 0.10250928211070146 0.23684740955872674 1.5392353032051315e-07 6.81269498441011 1.039465096620264 GPQITGPSLEGDLGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPQITGPSLEGDLGLK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 8792900.0 2711100.0 2085700.0 3996100.0 False True 2625037.6144811087 2918530.886781815 2949401.529569689 1.0 1.1118053587810097 1.1235654351386113 21.32390666480258 -13.812812915530463 0.3199641325689291 4.044318664296499e-10 1.1259202295411121 0.99968635566715 0.0009861609582658374 15.965110482260803 0.1799216906192089 10.63022778653717 0.003918338319760669 1.5388173860831695e-14 13.812812915530463 1.1259202291366803 GPQK(ub)FQFDGDKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPQKFQFDGDKK 12 2 P52209-2;P52209;K7ELN9 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 6415400.0 1111200.0 3232700.0 2071500.0 True False 924012.0345066765 3215284.8034592913 2504641.0724661713 1.0 3.479700137429389 2.710615207304504 19.817552116132298 -9.972923042135923 5.588759652923255 0.999996188198351 3.0951576723692296 0.9082162664981184 0.3139776079530568 107902854.8283004 4.42676642803377 5293.004417430944 0.10748288651588525 1.0643316032363376e-10 9.972923042135923 2.0951614841708786 GPQLFHMDPSGTFVQCDAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPQLFHMDPSGTFVQCDAR 19 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 24077200.0 3325900.0 11069000.0 9682300.0 False True 4360287.108061418 9417548.346624069 8680468.475179818 1.0 2.15984592602002 1.9908020412534602 22.055991703349097 -10.286956937565993 6.191304503871593 0.9999586135317423 2.0753239836367365 0.9818027494355867 0.0690118769693214 3.942727452064471e-05 4.540856038241628e-06 0.06682301098052089 0.022273487516057615 5.164675770338453e-11 10.286956937565993 1.0753653701049943 GPQLFHMDPSGTFVQCDAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPQLFHMDPSGTFVQCDAR 19 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 9470200.0 4557300.0 1071700.0 3841200.0 False True 4412631.006039901 1499635.398841668 2835074.486470084 1.0 0.3398506235370698 0.6424907232418718 22.073207680333134 -10.49675994177218 6.272985953095364 1.000354612726603 0.4911706733896407 0.7903139316907084 0.12355230333029854 0.0006131581370016498 4.918928038193149e-05 0.11970921839182821 0.03987633443198446 3.185958087760625e-11 10.49675994177218 -0.5091839393369623 GPQLFHMDPSGTFVQCDAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPQLFHMDPSGTFVQCDAR 19 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 17073200.0 3325900.0 9490300.0 4257000.0 False True 4555575.109067977 9070987.165774679 3251584.275667051 1.0 1.9911837580547558 0.7137593383532844 22.11920176487199 -6.699589360646979 1.832493250244015 1.6157336468657428 0.7176068902520789 0.4155856877627352 0.4184220696788824 0.3963616735083705 2.5873985502538637 0.18218765848999136 0.4687485187699973 1.9971497916357722e-07 6.699589360646979 -0.8981267566136639 GPQVSGELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPQVSGELK 9 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 3714300.0 0.0 1455100.0 2259200.0 False True 0.0 1238004.7519353745 2025439.6557766465 0.0 GPQVSGELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPQVSGELK 9 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 4039800.0 0.0 1247800.0 2792000.0 False True 0.0 1192668.070077197 2132587.1030449625 0.0 GPQVSGELKGPGVDVNLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPQVSGELKGPGVDVNLK 18 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 34494400.0 7073400.0 13472000.0 13949000.0 False True 10730864.93480745 11067816.342783561 11191974.035936115 1.0 1.0314002095845183 1.0429703573691416 23.355263029855518 -13.999999999993168 0.13874710715511965 0.8501643222526739 1.0575074798201891 0.9996078749105688 0.0003594529891155389 11.933047002559523 0.11661182065587919 0.48443849769106945 0.012985507396190954 1.000000000015731e-14 13.999999999993168 0.2073431575675152 GPQVSGELKGPGVDVNLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPQVSGELKGPGVDVNLK 18 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 29180700.0 7073400.0 13306000.0 8801300.0 False True 9156655.737559047 12565509.403085953 7199553.708964158 1.0 1.3722815144774274 0.7862645397306804 23.126389351947967 -6.735057940569298 1.7047820309825155 1.2227643506653814 0.7862773768996355 0.5825639339530759 0.15644586714931336 0.32683058331107895 1.8630316985352162 0.07265748531002722 0.17927188530127527 1.8405264347674158e-07 6.735057940569298 -0.43648697376574586 GPQVSSALNLDTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPQVSSALNLDTSK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 63384000.0 11809000.0 27500000.0 24075000.0 False True 15481713.35851866 23397107.194160398 21583949.94370697 1.0 1.5112737622988202 1.3941577036000745 23.884061807338128 -10.02070278998995 4.742157657768805 0.9999899363750852 1.4527157328289295 0.9522059447333764 0.04781243079812201 33020283.212412115 1.3000226897963367 3705.203937831456 0.016367466791008 9.534484345195777e-11 10.02070278998995 0.45272579645384436 GPQVSSALNLDTSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPQVSSALNLDTSK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 52625200.0 10516000.0 5231200.0 36878000.0 False True 10182175.336167375 7320045.4403476175 27218545.483714372 1.0 0.7189078167163955 2.673156234801156 23.279542478222037 -6.870414919452597 1.1319751199613113 0.840636606004675 2.7884748316947694 0.965091642641988 0.1611764113696289 0.13645364313310723 0.3265481252436849 0.11047906047772182 0.2617390074863206 1.347674715969967e-07 6.870414919452597 1.9478382256900943 up GPQVSSALNLDTSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPQVSSALNLDTSK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 135688000.0 15983000.0 93764000.0 25941000.0 False True 24247379.513816215 77031081.61852418 20813749.9796558 1.0 3.1768827462213673 0.8583917271470953 24.531325503606023 -6.660384015994914 1.9716760349200488 2.4007932228793054 0.8680785995475032 0.23720877359832093 0.9267825926850477 0.4835129337328432 3.61382778151287 0.37972120321014746 1.0273331731289401 2.1858279955825726e-07 6.660384015994914 -1.532714623331802 GPQVSSALNLDTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPQVSSALNLDTSK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 46792000.0 11809000.0 14887000.0 20096000.0 False True 16175106.426225584 14229243.115274291 15349738.690111596 1.0 0.8797001231598478 0.948972964111335 23.94727186886102 -10.17530205701745 4.415823536864364 1.0000159821908146 0.9143365436370945 0.6709376171785544 0.02828051897753832 39664909.3204324 0.3102049507683311 7882.9902214559315 0.009681173850475275 6.678792379772766e-11 10.17530205701745 -0.08567943855372007 GPQVSSALNLDTSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPQVSSALNLDTSK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 27581000.0 10516000.0 8834300.0 8230700.0 False True 8744519.937789967 8786707.872428738 9951701.31554298 1.0 1.0048244997940312 1.1380500457819422 23.059947753656314 -6.914568634095957 0.8640395816040369 0.9964468663497187 1.1570622612687138 0.9925345228034181 0.005527248164793678 0.10147395076774335 0.12295193500503987 0.0046300494026577845 0.013224295094502582 1.2173945856585096e-07 6.914568634095957 0.16061539491899512 GPQVSSALNLDTSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPQVSSALNLDTSK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 80783000.0 15983000.0 46054000.0 18746000.0 False True 20690308.572031327 43491054.41528037 15334420.350203058 1.0 2.1020012468093663 0.7411402443234592 24.302451825698473 -6.691306833348291 1.8620009071481365 1.6900597540708466 0.7458049699587561 0.37639350032286356 0.4659497210625631 0.4138961425154772 2.783274117094883 0.20012431631315167 0.5202369252545649 2.0356033956051293e-07 6.691306833348291 -0.9442547841120905 GPSAAAK(ub)PK(ub)AGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPSAAAKPKAGLR 13 2 Q8N531-2;Q8N531 Q8N531-2 FBXL6 F-box/LRR-repeat protein 6 2 1843640.0 536330.0 596460.0 710850.0 True False 703133.8238271086 507470.4929828706 637298.0609546874 1.0 0.7217267549735326 0.9063680900542066 19.423439770559426 -10.099669535553685 4.736022987124286 1.0000101254984304 0.8140474229862104 0.5748910366783198 0.07537950940428555 8.05953069884334e-06 1.5322020524444032e-06 0.07298986994583113 0.024328632046115958 7.949328869742814e-11 10.099669535553685 -0.18596270251222002 GPSAAAK(ub)PK(ub)AGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPSAAAKPKAGLR 13 2 Q8N531-2;Q8N531 Q8N531-2 FBXL6 F-box/LRR-repeat protein 6 2 2496580.0 784880.0 564100.0 1147600.0 True False 759964.4140215913 789348.0717426388 847009.1327379639 1.0 1.038664517941774 1.1145378877094363 19.535572339155443 -6.960416139177926 0.42954790299176127 0.9969716982001612 1.159138059365658 0.9997852614297827 0.0006971419724308709 0.0795530705615844 0.020586241571614743 0.0009889434662307456 0.0063004851006595326 1.0954280584657543e-07 6.960416139177926 0.16216636116549676 GPSAAAK(ub)PK(ub)AGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPSAAAKPKAGLR 13 2 Q8N531-2;Q8N531 Q8N531-2 FBXL6 F-box/LRR-repeat protein 6 2 1669380.0 536330.0 467280.0 665770.0 True False 734625.694773273 446634.02451167884 508528.83796355495 1.0 0.6079749560754517 0.692228493478576 19.486649832082318 -9.957634759431347 5.652134936315776 1.000000449110087 0.6501017247766703 0.9583258120693318 0.03439636261158904 1.946434663613281e-07 3.591122069012574e-08 0.03330417756876856 0.011101378296887305 1.1024660909902963e-10 9.957634759431347 -0.3498987243334166 GPSAAAK(ub)PK(ub)AGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPSAAAKPKAGLR 13 2 Q8N531-2;Q8N531 Q8N531-2 FBXL6 F-box/LRR-repeat protein 6 2 2430910.0 784880.0 892570.0 753460.0 True False 652662.4960795544 887761.5482487276 911005.002394574 1.0 1.3602153541552913 1.3958286371085273 19.31597761458972 -12.09458789823911 0.36341032611082863 1.5123760350038562e-10 1.400270542987699 0.9996598824199062 0.0032973523418397778 5.787063368343344 0.18969146510464205 4.390472975972521 0.010158828269139787 8.042889494838133e-13 12.09458789823911 1.4002705428364612 GPSFDVQVGLHELLGHGSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPSFDVQVGLHELLGHGSGK 20 0 G3V1D3;G3V180;Q9NY33;Q9NY33-4 G3V1D3 DPP3 Dipeptidyl peptidase 3 0 21951700.0 7427500.0 7187300.0 7336900.0 False True 7191718.078107946 10057226.371274354 5415145.787717992 1.0 1.3984455817156127 0.7529696977697229 22.777905036326768 -6.73971349881041 1.6877569429845172 1.237150853350104 0.7526152260612192 0.6036635360166835 0.16741074983439114 0.31832839839326044 1.7803344997867805 0.07847397848733038 0.19262780931301782 1.820901699248406e-07 6.73971349881041 -0.4845356272888849 GPSFDVQVGLHELLGHGSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPSFDVQVGLHELLGHGSGK 20 0 G3V1D3;G3V180;Q9NY33;Q9NY33-4 G3V1D3 DPP3 Dipeptidyl peptidase 3 0 148818000.0 40783000.0 59106000.0 48929000.0 False True 61870792.6366744 48558072.50271425 39258161.703657456 1.0 0.784830296063333 0.6345184865206798 25.88275518087966 -7.406606534400308 0.08858664166236103 1.4804475814909395 2.347303768042759e-10 0.9999988863306828 0.00015817810669086825 0.12410294950023641 0.006352945415172686 0.04275449661309901 0.060895569650579816 3.9209695137935236e-08 7.406606534400308 -1.480447581256209 GPSFDVQVGLHELLGHGSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPSFDVQVGLHELLGHGSGK 20 0 G3V1D3;G3V180;Q9NY33;Q9NY33-4 G3V1D3 DPP3 Dipeptidyl peptidase 3 0 20158600.0 7427500.0 5474600.0 7256500.0 False True 6176295.344040982 5445107.243176981 8773800.59973486 1.0 0.8816138056659698 1.4205604024749243 22.558310311761044 -6.849122024573959 1.2392590225678008 0.936867109314483 1.441750343083339 0.9390255585096595 0.057106171639375335 0.15842621525040637 0.4686338202039549 0.036065566261283176 0.08341551008568898 1.415396037476584e-07 6.849122024573959 0.5048832337688559 GPSFDVQVGLHELLGHGSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPSFDVQVGLHELLGHGSGK 20 0 G3V1D3;G3V180;Q9NY33;Q9NY33-4 G3V1D3 DPP3 Dipeptidyl peptidase 3 0 110169000.0 40783000.0 36877000.0 32509000.0 False True 52794397.453116044 34824762.53251171 26592695.57050843 1.0 0.6596298890130865 0.5037029846609012 25.65388150297211 -13.999999999999995 0.10491231159448618 2.6593919545364595 0.1955099489400606 0.9997689211235401 0.0031500631335165227 12.044951072368201 0.09741749583045599 4.277441294934272 0.27420156966419984 1.0000000000000123e-14 13.999999999999995 -2.463882005596399 GPSGCVESLEVTCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPSGCVESLEVTCR 14 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQX5;A0A0U1RQX9 P47897 QARS Glutamine--tRNA ligase 0 6660820.0 895220.0 2421400.0 3344200.0 False True 1173642.0893228108 2060136.5585432756 2998174.2638315614 1.0 1.7553362965467354 2.5545899308719426 20.162561084514635 -6.970409581667617 0.2482072079016731 0.7406942595826995 3.5925878895540246 0.9999854036591617 0.002425039131190251 0.07617001715085855 0.008553218756068412 0.018045097469902956 0.07682732361557908 1.070509235350389e-07 6.970409581667617 2.8518936299713253 GPSGCVESLEVTCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPSGCVESLEVTCR 14 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQX5;A0A0U1RQX9 P47897 QARS Glutamine--tRNA ligase 0 4700320.0 895220.0 1729500.0 2075600.0 False True 1226207.0264108446 1653084.9713083128 1585386.028323829 1.0 1.3481287708381158 1.2929187275694505 20.225771146037527 -10.058646268442113 4.436150933009027 0.9999787521421875 1.320523749212379 0.9782319814106206 0.02253940587744512 7812567.673552287 0.15837610544528402 1705.64571216278 0.007715838130555335 8.736826906049096e-11 10.058646268442113 0.32054499707019146 GPSSEAMHVGHLIPFIFTK ddPTM_RPMI8226_Bortezomib_1h_R1 2 GPSSEAMHVGHLIPFIFTK 19 0 P23381;P23381-2;G3V3Y5;G3V3H8;G3V277;G3V423;G3V456;G3V5U1 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 12398300.0 2033200.0 3466700.0 6898400.0 False True 2665544.8895368082 2949481.8730907645 6184619.742125362 1.0 1.106521178716032 2.32020843708247 21.34599904755404 -6.924153084887775 0.7932962716556631 0.9770142285393034 2.535943991400968 0.9952594907401421 0.041229985925159175 0.09578882159465962 0.09339347581625167 0.03632931074137867 0.1135514124262191 1.1908221799610404e-07 6.924153084887775 1.5589297628616645 up GPSSEAMHVGHLIPFIFTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPSSEAMHVGHLIPFIFTK 19 0 P23381;P23381-2;G3V3Y5;G3V3H8;G3V277;G3V423;G3V456;G3V5U1 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 18984100.0 7730500.0 3739900.0 7513700.0 False True 7485099.508961755 5233261.573320857 5545636.563831688 1.0 0.6991572479504355 0.7408901588004291 22.835590065318137 -10.396129083324892 5.083981991713037 1.0002382606920674 0.7200237033754107 0.983609253073816 0.0170373895106659 4.604973688109682e-05 5.469766743087798e-06 0.016510290370206737 0.00549879381979404 4.016714061846419e-11 10.396129083324892 -0.2802145573166568 GPSSEAMHVGHLIPFIFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GPSSEAMHVGHLIPFIFTK 19 0 P23381;P23381-2;G3V3Y5;G3V3H8;G3V277;G3V423;G3V456;G3V5U1 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 29564300.0 2033200.0 10608000.0 16923100.0 False True 2784928.985164018 10139303.48403502 12926212.322184883 1.0 3.6407763135252327 4.641487230391117 21.409209109076933 -9.223972171174278 0.331403100369668 3.0580437112166906e-18 4.96157544783339 0.998378220785411 0.06185949592735742 0.630112408177057 0.12495319462424613 1.085859462624956 0.30884496387490745 5.970735447795247e-10 9.223972171174278 4.96157544783339 GPSSEAMHVGHLIPFIFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPSSEAMHVGHLIPFIFTK 19 0 P23381;P23381-2;G3V3Y5;G3V3H8;G3V277;G3V423;G3V456;G3V5U1 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 16573500.0 7730500.0 2812000.0 6031000.0 False True 6428253.269216934 2796851.1978617036 7292054.2158066435 1.0 0.43508727499195216 1.1343756865844419 22.615995340752413 -6.691786086338413 1.8604242209632973 0.6464191164515098 1.13198712116573 0.37862200630034093 0.23883390967738247 0.41284987009227625 2.7719372415527705 0.10265462194350596 0.2666845742531508 2.0333583039167064e-07 6.691786086338413 0.4855680047142201 GPSSVEDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPSSVEDIK 9 0 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 0 56575200.0 15137000.0 5776200.0 35662000.0 False True 14656484.220574887 8082666.782485067 26321052.362932444 1.0 0.5514737819004749 1.7958639989515865 23.805035737270636 -6.809210725985457 1.4178672714122837 0.7553304510240147 1.817239792278522 0.8577556647962237 0.19407328374477562 0.2078767673628733 0.8238054997241957 0.10763228534166162 0.2490636561825904 1.5516339519634467e-07 6.809210725985457 1.0619093412545073 GPSSVEDIK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPSSVEDIKAK 11 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 14290600.0 5039600.0 3080400.0 6170600.0 True False 4879620.656537575 4310419.7840737915 4554334.745968001 1.0 0.8833514093557284 0.9333378691776449 22.218337565840976 -10.129863475925509 4.41855246221579 1.000010669325595 0.9083446393088412 0.817611548442827 0.020406886831576817 28493915.438049506 0.4168260653769881 3798.8312559433334 0.006985820143928725 7.415433149596245e-11 10.129863475925509 -0.09166603001675377 GPSSVEDIK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPSSVEDIKAK 11 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 35900100.0 6736600.0 7380100.0 21783400.0 True False 10219914.71142927 6063063.49401551 17477901.441996608 1.0 0.5932596959184977 1.7101807535096638 23.284879820769707 -6.80816392670956 1.4221804882691413 0.7778402855162276 1.7289199542776954 0.8549827826859946 0.17576579412661564 0.20932233949789394 0.8347652039439558 0.09718664176917965 0.22501141939577768 1.555378435117018e-07 6.80816392670956 0.9510796687614678 GPSSVEDIK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPSSVEDIKAK 11 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 9744500.0 3689600.0 3064800.0 2990100.0 True False 5053744.827690917 2929387.0020617056 2283899.9630425307 1.0 0.5796467969674199 0.45192229542900303 22.268921391280262 -13.999999999999998 0.1668825783511443 3.1031129369876305 0.335432459470266 0.9995199755380394 0.005129907362251442 12.062716035492212 0.1292955576799081 8.210780950399332 0.1071637824481859 1.0000000000000041e-14 13.999999999999998 -2.7676804775173647 GPSSVEDIK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPSSVEDIKAK 11 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 19256000.0 5039600.0 9378600.0 4837800.0 True False 4190650.692134495 9328075.62029365 5849361.612540105 1.0 2.2259253527863057 1.395812259780772 21.998742841275252 -10.117030758019665 5.2698863289769005 0.9999819782069909 1.8108688062841987 0.5599035728967081 0.33889225111348753 7.175929587039901e-05 1.2023292386469304e-05 0.32813829040058295 0.10937700372644037 7.637816883840136e-11 10.117030758019665 0.8108868280772078 GPSSVEDIK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPSSVEDIKAK 11 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 1 38720700.0 6736600.0 9186900.0 22797200.0 True False 8720661.498238502 8675640.939065874 18648343.519025344 1.0 0.9948374834659364 2.138409284982813 23.056006142862156 -6.90588332374019 0.9233149981923356 0.9598200276212969 2.273887092748366 0.989273071730966 0.055707902653395584 0.10720359008032408 0.15400024176409083 0.0447001037779508 0.12014122876912502 1.241985931010083e-07 6.90588332374019 1.3140670651270692 up GPSTEYGFYHDFFLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPSTEYGFYHDFFLGK 16 0 Q9BW92;U3KQG0;F6S7Q7;Q9BW92-2 Q9BW92 TARS2 Threonine--tRNA ligase, mitochondrial 0 3423580.0 813220.0 923460.0 1686900.0 False True 1066139.2952336823 785683.3676188858 1512355.7698874061 1.0 0.7369425094182233 1.4185348731151681 20.023964513438283 -6.802049983911179 1.4473964017742977 0.8552366205496558 1.4284426768866314 0.8381383907769141 0.11291588816369827 0.21783487158549994 0.9007102063410592 0.06136511398575803 0.14254663332624418 1.5774297093820258e-07 6.802049983911179 0.5732060563369756 GPSTEYGFYHDFFLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPSTEYGFYHDFFLGK 16 0 Q9BW92;U3KQG0;F6S7Q7;Q9BW92-2 Q9BW92 TARS2 Threonine--tRNA ligase, mitochondrial 0 3097920.0 813220.0 1158000.0 1126700.0 False True 1113889.410444168 1106835.731006086 860596.665114885 1.0 0.9936675226715109 0.7726051231349067 20.087174574961175 -6.913026569292176 0.8748608557837244 1.0062068994086155 0.7421058153684957 0.9920146832097165 0.009448452186340595 0.10245074616152605 0.1281592713169955 0.007853244894978299 0.022161519839456797 1.2217249151231247e-07 6.913026569292176 -0.2641010840401198 GPSTPNVK(ub)NSNYCLPSYTAYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPSTPNVKNSNYCLPSYTAYK 21 1 Q9Y4E8-2;Q9Y4E8-3 Q9Y4E8-2 USP15 Ubiquitin carboxyl-terminal hydrolase 15 1 9032600.0 2639300.0 4036700.0 2356600.0 True False 3460147.85901756 3434440.0949333617 2112761.6381034185 1.0 0.9925703278785615 0.6105986576837485 21.722402257739244 -6.911109900267056 0.8881457237617704 1.0114154807987557 0.5600456597711647 0.9913336454622781 0.01692804539724408 0.10368854892809447 0.13482114367155815 0.013935727156911625 0.038771100112107236 1.2271286611688317e-07 6.911109900267056 -0.45136982102759093 GPSTPNVK(ub)NSNYCLPSYTAYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPSTPNVKNSNYCLPSYTAYK 21 1 Q9Y4E8-2;Q9Y4E8-3 Q9Y4E8-2 USP15 Ubiquitin carboxyl-terminal hydrolase 15 1 40659000.0 12109000.0 16497000.0 12053000.0 True False 18370238.28647939 13552981.458350696 9670719.266982442 1.0 0.7377684081716988 0.5264340677660208 24.130867004460065 -6.973574663485867 0.1499400196243726 1.24587523780189 0.012769233654926635 0.9999985464675497 0.00023346346885317086 0.07515892916550027 0.004582803142393262 0.010791986752389461 0.026370137473753125 1.0627358630513545e-07 6.973574663485867 -1.2331060041469635 GPSTPNVK(ub)NSNYCLPSYTAYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPSTPNVKNSNYCLPSYTAYK 21 1 Q9Y4E8-2;Q9Y4E8-3 Q9Y4E8-2 USP15 Ubiquitin carboxyl-terminal hydrolase 15 1 8349600.0 2639300.0 2970600.0 2739700.0 True False 3615120.534400648 2839349.0695394496 2092639.2858926558 1.0 0.7854092394764886 0.5788574035027563 21.785612319262135 -6.971590896742682 0.21685001638645426 1.0991237653448238 0.25933165793842305 0.9999922730861747 0.0004779156624296165 0.07578978019154162 0.007153638200188392 0.005861784083946587 0.021077179431357 1.067601322882553e-07 6.971590896742682 -0.8397921074064008 GPSTPNVK(ub)NSNYCLPSYTAYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPSTPNVKNSNYCLPSYTAYK 21 1 Q9Y4E8-2;Q9Y4E8-3 Q9Y4E8-2 USP15 Ubiquitin carboxyl-terminal hydrolase 15 1 33025700.0 12109000.0 9590700.0 11326000.0 True False 15675339.204074765 9056969.114097137 9264784.214573773 1.0 0.5777845695194144 0.5910420242877689 23.901993326552514 -9.904376172901141 5.586493705145747 1.0000003147502106 0.5844132969149887 0.99923734620377 0.00541233324898036 7388962.067886486 1.2135044446929784 29.909540430355616 0.0018527856301503805 1.2463035357116005e-10 9.904376172901141 -0.4155870178352219 GPSWDPFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPSWDPFR 8 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 21719300.0 2201100.0 10431000.0 9087200.0 False True 2885663.4154827204 8874735.45971954 8146943.714577534 1.0 3.075457592213662 2.8232480859915863 21.460471602648635 -10.028652400496586 5.648440223086764 0.9999936425057114 2.949352839103408 0.9876010530168562 0.10296409975666504 8.243601656678735e-06 1.4176030398113893e-06 0.09969488554048046 0.03323152030083092 9.361546514338867e-11 10.028652400496586 1.9493591965976964 GPSWDPFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPSWDPFR 8 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 18609500.0 8420100.0 2758800.0 7430600.0 False True 8152808.534429719 3860403.2269519386 5484302.946778241 1.0 0.4735059348749897 0.6726887947408251 22.958865703601383 -10.129257718663029 5.235745703274265 1.0000117853823685 0.5730973648075536 0.8596453404227477 0.08131606203116931 1.1186935545699665e-05 1.8606408079759767e-06 0.07873610972680596 0.026244646168645528 7.425783469100536e-11 10.129257718663029 -0.4269144205748149 GPSWDPFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPSWDPFR 8 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 21588400.0 2201100.0 10027000.0 9360300.0 False True 3014906.1524909097 9583973.985145096 7149589.921429724 1.0 3.1788631222324564 2.371413755457279 21.523681664171527 -10.30609758109139 5.793368132903279 0.9998304881497193 2.7751384388448765 0.8656681910426616 0.32963982362212646 0.0007217918055596991 8.645258312470704e-05 0.31920120623579795 0.10639079559459913 4.9419963340507555e-11 10.30609758109139 1.7753079506951572 GPSWDPFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPSWDPFR 8 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 12056900.0 8420100.0 2336400.0 1300400.0 False True 7001686.223676808 2323813.3494609087 1572307.6276297423 1.0 0.3318933861392892 0.22456128101154374 22.73927097903566 -13.999999999999998 0.2573459869336949 5.823933005068691 0.18432329833210165 0.9995569666336653 0.007220780386171014 14.3013901868214 0.16052554837517247 35.82023412957788 0.04758935423100194 1.0000000000000041e-14 13.999999999999998 -5.639609706736589 GPSWDPFRDWYPHSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPSWDPFRDWYPHSR 15 1 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 10691000.0 4830800.0 1476100.0 4384100.0 False True 6333225.581533752 1255871.633792734 3930475.387256731 1.0 0.19829889487192284 0.6206119356804698 22.594509036629344 -10.222649663358148 5.299401361845368 1.0000448498772314 0.4094554153090858 0.7227770318038855 0.17240857695108625 9.136522014457784e-05 1.3402534438845392e-05 0.16694651377696335 0.05564462893951515 5.988945164386749e-11 10.222649663358148 -0.5905894345681456 GPSWDPFRDWYPHSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPSWDPFRDWYPHSR 15 1 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 6875130.0 3217800.0 665430.0 2991900.0 False True 3115652.700334667 931139.6691716088 2208231.6349239396 1.0 0.2988586208827417 0.7087541030124259 21.571102995461384 -10.611385741061587 6.312995023663356 1.001747154490891 0.5038063619486438 0.6614606495045776 0.1673391298483045 0.00412678451594217 0.0002540355537045393 0.16249083110592336 0.05400847192261033 2.4468889456599826e-11 10.611385741061587 -0.4979407925422471 GPSWDPFRDWYPHSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPSWDPFRDWYPHSR 15 1 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 17936500.0 4830800.0 9493100.0 3612600.0 False True 6616877.307461318 9073663.452516316 2759378.283832464 1.0 1.3712908719472068 0.4170212255138744 22.657719098152235 -6.80118881715164 1.451002283745305 1.2045534284935016 0.4034508855896408 0.8356218182789225 0.15923941837125793 0.21906988031187125 0.9104491379265492 0.08632930497371548 0.20063115377997012 1.5805607133450338e-07 6.80118881715164 -0.8011025429038607 down GPSWDPFRDWYPHSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPSWDPFRDWYPHSR 15 1 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 5321750.0 3217800.0 986650.0 1117300.0 False True 2675743.2727102074 981334.7206153095 1350922.2641884868 1.0 0.3667521957819724 0.5048773841520918 21.35150827089566 -9.97226338171464 7.1553376096884715 1.000000024981541 0.4358147899684395 0.9569803700893298 0.056389372022102084 2.2517407719776097e-08 3.183691279285938e-09 0.05459877712691919 0.01819959156205772 1.065949470719204e-10 9.97226338171464 -0.5641852350131016 GPSYGEDVSNTTTAQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPSYGEDVSNTTTAQKR 17 1 P29590;P29590-4;P29590-2;P29590-5;P29590-9;P29590-3;P29590-8;H3BVD2 P29590 PML Protein PML 1 6188100.0 1767300.0 1416000.0 3004800.0 True False 1711198.0288711118 1981416.1843424512 2217752.7379322364 1.0 1.1579116799530234 1.2960234295006183 20.70657529510041 -6.972697081045068 0.1826090760773829 0.8968540518336732 1.5608256328131953 0.9999964924250824 0.00022643126413423318 0.07543686320211841 0.0057759151880436045 0.0051977028361607685 0.01537818947174745 1.0648855133497813e-07 6.972697081045068 0.6639715809795221 GPSYGEDVSNTTTAQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPSYGEDVSNTTTAQKR 17 1 P29590;P29590-4;P29590-2;P29590-5;P29590-9;P29590-3;P29590-8;H3BVD2 P29590 PML Protein PML 1 5748000.0 1767300.0 2173500.0 1807200.0 True False 1469588.2546649124 2161790.9240940292 2185077.164451298 1.0 1.4710181013163781 1.4868635194349233 20.486980570534687 -11.5793927574116 0.5415631037553327 5.922280700081616e-07 1.4855639069589792 0.9999150601118162 0.002081651142152798 4.688701177892077 0.2673072355840416 5.496851272390986 0.0030006878729370878 2.6339482778832983e-12 11.5793927574116 1.4855633147309093 GPSYGLSAEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPSYGLSAEVK 11 0 B4DDF4;B4DUT8;Q99439;A0A087X271;H3BVI6;Q99439-2;K7ES69;Q15417-3;Q15417 B4DDF4 CNN2;CNN3 Calponin;Calponin-2;Calponin-3 0 34384400.0 13261000.0 8221400.0 12902000.0 False True 18163950.065050203 7858151.363465848 9854813.325030852 1.0 0.4326234841718681 0.5425479199038755 24.11457463994441 -9.975720975794639 6.111841308191761 1.0000002814429598 0.4875857020381125 0.9666365840900196 0.04487646296797272 1.7212901158649936e-07 2.8815202988355926e-08 0.043451472383792204 0.014483816142611884 1.0574967082925245e-10 9.975720975794639 -0.5124145794048474 GPSYGLSAEVK(ub)NR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPSYGLSAEVKNR 13 1 B4DDF4;B4DUT8;Q99439;A0A087X271;H3BVI6;Q99439-2;K7ES69 B4DDF4 CNN2 Calponin;Calponin-2 1 11724300.0 2463300.0 3029600.0 6231400.0 True False 3188790.4089022516 2861000.096767563 5097349.13956339 1.0 0.8972054383945757 1.5985212215054811 21.60457784534824 -6.8696499043608075 1.1358903341306765 0.9419794129182489 1.639331195766883 0.9643354168763606 0.058399298330917795 0.13719392042267692 0.3310498340985453 0.03990746575511967 0.09442952706139982 1.350050753716428e-07 6.8696499043608075 0.6973517828486341 GPTK(ub)EELCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPTKEELCK 9 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 9605000.0 2675700.0 3945400.0 2983900.0 True False 3507868.6115156584 3356761.699048749 2675154.6515899133 1.0 0.9569234400710294 0.7626154077743661 21.742163281455554 -6.94212580148721 0.6394823279688444 1.002126406815296 0.7067687871994032 0.9984292746936214 0.004092413809574031 0.0868101162304653 0.0502930146098806 0.004051014983945698 0.016573401014049544 1.1425473267329151e-07 6.94212580148721 -0.2953576196158928 GPTK(ub)EELCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPTKEELCK 9 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 26595200.0 7182500.0 11484600.0 7928100.0 True False 10896377.611085843 9435083.400410632 6361107.559990333 1.0 0.8658917428496138 0.5837818573319834 23.37734526975577 -6.959045105930004 0.44868854557311283 1.00922038948559 0.4292939502415686 0.9997331275563701 0.0028337458671503085 0.08004400436312493 0.022405067960169455 0.0037634069793998255 0.02333976669786732 1.0988917023472972e-07 6.959045105930004 -0.5799264392440214 GPTK(ub)EELCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPTKEELCK 9 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 10025200.0 2675700.0 3647900.0 3701600.0 True False 3664978.598073658 3486723.716007866 2827358.316845002 1.0 0.9513626403822701 0.7714528860635324 21.805373342978445 -6.946673978419225 0.5942415011373442 1.0020548610499336 0.7116417107746545 0.9989137167871305 0.0032398624669331706 0.08484952021934113 0.04170678281909633 0.0033443739426171908 0.015091462586642288 1.1306443623372944e-07 6.946673978419225 -0.29041315027527903 GPTK(ub)EELCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GPTKEELCK 9 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 14620800.0 7182500.0 4242400.0 3195900.0 True False 9297887.838241573 4006306.7106306786 2614278.9927031896 1.0 0.4308835275634338 0.2811691255244917 23.14847159184822 -13.999999999999943 0.18745506284795144 4.024467510216295 0.17096827957584113 0.9994910111464271 0.006986257989986082 12.3103875303655 0.1372956969660039 13.58839721136625 0.10508325195639642 1.000000000000131e-14 13.999999999999943 -3.8534992306404536 GPTVGGGLPGIGVQGLEGNLQMPGIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPTVGGGLPGIGVQGLEGNLQMPGIK 26 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 14601100.0 7446900.0 3300000.0 3854200.0 False True 7210502.23572697 4617707.209272663 2844669.3964784415 1.0 0.6404140874393753 0.39451751119131845 22.781668320850965 -8.14441670292885 0.17113218181888662 1.3242014742750936 1.1408206918653313e-09 0.9998940018196139 0.002559829958186589 0.08829763533008386 0.03317291654110081 0.10496936048999383 0.11792374308929579 7.171059022953206e-09 8.14441670292885 -1.3242014731342728 down GPTVGGGLPGIGVQGLEGNLQMPGIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GPTVGGGLPGIGVQGLEGNLQMPGIK 26 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 11987500.0 7446900.0 2084800.0 2455800.0 False True 6192427.303606705 2073568.7685995984 2969296.425663731 1.0 0.3348555690580127 0.47950444633145717 22.56207359628524 -10.046952611273632 7.4549901979002255 1.000000046554752 0.4071800076979913 0.9572561267226579 0.059052656864400956 4.570878414613444e-08 5.828655078087911e-09 0.057177493406299386 0.019059163048760486 8.975267241998107e-11 10.046952611273632 -0.5928200388567608 GPVGLEGLLTTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPVGLEGLLTTK 12 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 12506700.0 2555900.0 4423600.0 5527200.0 False True 3350809.651370807 3763616.123057745 4955298.364646202 1.0 1.123196037566043 1.4788361262535468 21.676078303367834 -6.952312178788296 0.5328552071580492 0.994503512391461 1.6237524024692909 0.9993704668337163 0.005093781293598995 0.08257035935577298 0.03222106084112064 0.005659237560698121 0.029420762491989716 1.116060714596323e-07 6.952312178788296 0.6292488900778299 GPVGLEGLLTTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPVGLEGLLTTK 12 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 6425260.0 2212500.0 659060.0 3553700.0 False True 2142265.3985612695 922226.0949524964 2622879.361285203 1.0 0.43049105660384424 1.224348469170398 21.030705791461713 -6.7141308858469815 1.780231210877118 0.6513719862498036 1.2227409023810527 0.48481157975236955 0.2398387666357739 0.3668316343686758 2.2686282352467697 0.10710519716847651 0.27076858075324767 1.9313861562485213e-07 6.7141308858469815 0.5713689161312491 GPVGLEGLLTTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPVGLEGLLTTK 12 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 9211600.0 2555900.0 2318300.0 4337400.0 False True 3500885.3006003886 2215869.840407092 3312995.451557027 1.0 0.6329455695183955 0.9463307612474082 21.739288364890726 -10.103840955019216 7.181446946968543 1.0000000771344366 0.7896381653829019 0.37530466133133866 0.12793896878005942 1.5802963129400358e-07 1.953487131652935e-08 0.12387642000138553 0.04129212461801005 7.873340701386571e-11 10.103840955019216 -0.21036191175153474 GPVLSLAFSPNGK(ub)YLASAGEDQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GPVLSLAFSPNGKYLASAGEDQR 23 1 O75529 O75529 TAF5L TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L 1 28069900.0 9154100.0 8376800.0 10539000.0 True False 8863508.106201004 11721699.924434911 7778519.736777095 1.0 1.3224673327973024 0.8775892844657253 23.07944638838775 -6.712297818068314 1.7871863723969743 1.1977805928980487 0.8785698917313992 0.47593711412823636 0.1358382262761484 0.3704721525481908 2.308070970273729 0.06045585801900558 0.15314995888407082 1.9395553685499517e-07 6.712297818068314 -0.3192107011666495 GPVSLLSLWSNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPVSLLSLWSNR 12 0 Q9NVM9;Q9NVM9-2;H0YH12 Q9NVM9 ASUN Protein asunder homolog 0 7171000.0 1769000.0 3807400.0 1594600.0 False True 2319176.1310203704 3239350.7611289597 1429606.0884832884 1.0 1.396767894340021 0.6164284244570519 21.14518095968342 -6.768466528366271 1.5801905965683443 1.2280184443162754 0.612276966301822 0.724720078297077 0.1671536698682829 0.26891025734666 1.324913308671581 0.08338846770053054 0.19879047124952456 1.7042506630423866e-07 6.768466528366271 -0.6157414780144533 GPVSLLSLWSNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPVSLLSLWSNR 12 0 Q9NVM9;Q9NVM9-2;H0YH12 Q9NVM9 ASUN Protein asunder homolog 0 14191600.0 1769000.0 4968400.0 7454200.0 False True 2423047.1054274794 4748879.65969831 5693671.484067977 1.0 1.9598792153322593 2.3497980998035475 21.20839102120631 -10.022855543613598 0.21841012828583292 4.658981062870702e-19 2.6415478028604373 0.9992951835277013 0.015058024618027585 1.5248028097507564 0.10010764961702587 1.1199913255516771 0.20867234580685148 9.487339816824886e-11 10.022855543613598 2.6415478028604373 GPVYLLFSVNGSGHFCGVAEMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GPVYLLFSVNGSGHFCGVAEMK 22 0 Q9Y5A9;Q9Y5A9-2;Q9BYJ9 Q9Y5A9;Q9BYJ9 YTHDF2;YTHDF1 YTH domain-containing family protein 2;YTH domain-containing family protein 1 0 23508300.0 6998700.0 5314600.0 11195000.0 False True 10617539.573505927 4366168.1068406785 8982303.343057191 1.0 0.41122221175757423 0.8459872723687171 23.33994615009434 -9.796398764829554 6.164501999755222 1.0000000141329928 0.6286047420628128 0.4931514892305632 0.17749209274919583 3.424440525382984e-08 7.062130001542374e-09 0.17185598494642138 0.057285326608240365 1.5980900045705279e-10 9.796398764829554 -0.37139527207017997 GPYHFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GPYHFR 6 0 P40429;M0QYS1;Q8J015 P40429 RPL13A;RPL13a 60S ribosomal protein L13a 0 8384790.0 957190.0 4851900.0 2575700.0 False True 1254885.3594411442 4128015.432558066 2309191.271859027 1.0 3.289555815996175 1.8401611386138188 20.259124141531924 -10.251093186287912 6.103922976667152 0.9999580042658633 2.564858477305 0.6084927208554891 0.5917128992487808 0.00033817273053381446 4.149303991327502e-05 0.5729387245027122 0.19097451704388457 5.6092760524317576e-11 10.251093186287912 1.5649004730391367 GPYHFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GPYHFR 6 0 P40429;M0QYS1;Q8J015 P40429 RPL13A;RPL13a 60S ribosomal protein L13a 0 7348490.0 957190.0 3225900.0 3165400.0 False True 1311089.0100871252 3083369.0713752434 2417797.7134593604 1.0 2.3517618160572833 1.8441140874933362 20.322334203054815 -9.949102958222424 5.670943221502371 0.9999987949912679 2.097937951776432 0.8618194670155095 0.20724631734805957 3.1575264720654576e-06 5.852766689069203e-07 0.20066560513099277 0.06688846130374389 1.1243383953892504e-10 9.949102958222424 1.097939156785164 GQAFVIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQAFVIFK 8 0 P08579;P09012;M0QXK2;M0R221;M0R2B8;M0R268;M0R0G9;M0QZG7 P08579;P09012 SNRPB2;SNRPA U2 small nuclear ribonucleoprotein B;U1 small nuclear ribonucleoprotein A 0 126182000.0 39332000.0 31361000.0 55489000.0 False True 51564632.891629845 26682061.04422052 49747530.568072915 1.0 0.5174488704359931 0.9647606853446272 25.619878554550176 -10.52043297070541 9.161953379958028 1.0000104557037777 0.7411047778903102 0.30874717268305263 0.1826142837407378 3.9002827595244895e-05 2.0413781860629984e-06 0.1768226517201743 0.058938506642289445 3.0169424741068055e-11 10.52043297070541 -0.2589056778134675 GQAFVIFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQAFVIFK 8 0 P08579;P09012;M0QXK2;M0R221;M0R2B8;M0R268;M0R0G9;M0QZG7 P08579;P09012 SNRPB2;SNRPA U2 small nuclear ribonucleoprotein B;U1 small nuclear ribonucleoprotein A 0 98545000.0 30867000.0 13100000.0 54578000.0 False True 29887143.98074155 18330898.315597527 40282384.495096326 1.0 0.61333723715486 1.3478164565022734 24.833021703693724 -6.763655602197157 1.5985622707593776 0.7764267905719956 1.3510087468597076 0.7057488222785973 0.1627291567313848 0.27682842899445304 1.394969805818367 0.08028600306625346 0.19226140997888594 1.72323456734839e-07 6.763655602197157 0.574581956287712 GQAFVIFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQAFVIFK 8 0 P08579;P09012;M0QXK2;M0R221;M0R2B8;M0R268;M0R0G9;M0QZG7 P08579;P09012 SNRPB2;SNRPA U2 small nuclear ribonucleoprotein B;U1 small nuclear ribonucleoprotein A 0 57013000.0 17705000.0 20487000.0 18821000.0 False True 26859779.408879157 16830934.784338385 15101021.100462643 1.0 0.6266222267921719 0.5622168697137785 24.67894412061416 -13.999999999999998 0.24723250198788338 3.5608857118063653 0.5356301090453516 0.9995375642401138 0.004150156835595087 13.89001404783231 0.15734521024469256 17.63635569733819 0.030187151109023272 1.0000000000000041e-14 13.999999999999998 -3.0252556027610136 GQAFVIFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQAFVIFK 8 0 P08579;P09012;M0QXK2;M0R221;M0R2B8;M0R268;M0R0G9;M0QZG7 P08579;P09012 SNRPB2;SNRPA U2 small nuclear ribonucleoprotein B;U1 small nuclear ribonucleoprotein A 0 107652000.0 39332000.0 36696000.0 31624000.0 False True 53874103.307333864 35074649.38255558 24155062.516724207 1.0 0.6510484115617917 0.44836129111843587 25.683088616073068 -9.772456886165125 0.11854039367983048 1.7149013719774253 2.229251605660212e-15 0.9998898786442316 0.0023908016294443123 1.2831384096490523 0.0513408399808726 0.5179761723318043 0.2314755371355561 1.688663490318482e-10 9.772456886165125 -1.714901371977423 GQAFVIFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQAFVIFK 8 0 P08579;P09012;M0QXK2;M0R221;M0R2B8;M0R268;M0R0G9;M0QZG7 P08579;P09012 SNRPB2;SNRPA U2 small nuclear ribonucleoprotein B;U1 small nuclear ribonucleoprotein A 0 64886000.0 30867000.0 15898000.0 18121000.0 False True 25667278.139954615 15812354.318494083 21910017.31796256 1.0 0.6160510760928717 0.8536167021097821 24.613426979128 -10.35530689579022 5.970870069695178 1.000037509325871 0.7348338891013266 0.6242219187663972 0.09698576069438206 4.8433759660064734e-05 5.2294917771161365e-06 0.09391931745799179 0.03130201966571651 4.4125852020060704e-11 10.35530689579022 -0.26520362022454447 GQAFVIFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQAFVIFK 8 0 P08579;P09012;M0QXK2;M0R221;M0R2B8;M0R268;M0R0G9;M0QZG7 P08579;P09012 SNRPB2;SNRPA U2 small nuclear ribonucleoprotein B;U1 small nuclear ribonucleoprotein A 0 71450000.0 17705000.0 29790000.0 23955000.0 False True 22919471.51772597 28132160.31248541 19595435.79905657 1.0 1.2274349472119344 0.8549689195015433 24.45007044270661 -6.741436518105585 1.681303371416684 1.1350959982440236 0.8546754818810196 0.6114329360281812 0.09555607677793043 0.315222299998091 1.7501273532898536 0.04495055322353879 0.1101368533446854 1.8136917682899868e-07 6.741436518105585 -0.280420516363004 GQAVDYEGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQAVDYEGSR 10 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 9280410.0 536310.0 4471800.0 4272300.0 False True 703107.6036334285 3804624.8709398713 3830243.3787954054 1.0 5.411155918779463 5.4475920314358275 19.423385970774184 -10.319443709569569 0.9509673285563898 4.16632472857213e-10 5.438198434593159 0.9999892881454061 0.006834067943792556 1.720447527483153 0.5468062085351104 4.623232210284815 0.004875139341560227 4.792435653215567e-11 10.319443709569569 5.438198434176527 GQAVDYEGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQAVDYEGSR 10 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 6243990.0 1691000.0 959490.0 3593500.0 False True 1637320.1306066029 1342619.36067425 2652254.5473108026 1.0 0.8200102933913292 1.619875366907131 20.642904996013975 -6.847612044892663 1.2466326803093726 0.9041157936114599 1.650394846487543 0.9367475868580434 0.08616617488648295 0.16010398216448668 0.48002273225695197 0.05411869581586944 0.1250523147496926 1.4203257316335695e-07 6.847612044892663 0.7462790528760832 GQAVDYEGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQAVDYEGSR 10 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 8586610.0 536310.0 3656600.0 4393700.0 False True 734598.3002327934 3495039.321240813 3355998.551091923 1.0 4.757755796784772 4.56848123665466 19.486596032297076 -10.128168401074895 4.17668272160252 0.99916521535064 4.663118517298362 0.9980016337293528 0.0772710175408792 1719913.0290101198 595867.4476592795 12836.309133706593 0.026451924362649024 7.444432542509672e-11 10.128168401074895 3.663953301947722 GQCDLELINVCNENSLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQCDLELINVCNENSLFK 18 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 5081700.0 1187500.0 1906000.0 1988200.0 False True 1556823.999766358 1621632.2295298108 1782480.1361610875 1.0 1.0416284883668154 1.1449464656432553 20.57017442509863 -6.955617940608068 0.49334052997275885 0.9978059252781636 1.1931749984139328 0.9995715281501443 0.0012613022223895037 0.08130540855251837 0.0272115380947743 0.0014983890941565113 0.008521502314947327 1.1075977361095253e-07 6.955617940608068 0.19536907313576923 GQCDLELINVCNENSLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQCDLELINVCNENSLFK 18 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 5566600.0 1187500.0 1429900.0 2949200.0 False True 1626550.840980853 1366722.289953024 2252659.700680593 1.0 0.8402579590619217 1.384930396225537 20.633384486621523 -6.828201939768052 1.3360809642662541 0.9145345010590072 1.399040052569422 0.902199274846135 0.07149301035283609 0.183042334372852 0.6396956425505339 0.04202282086546454 0.09670829480078495 1.4852448673437992e-07 6.828201939768052 0.48450555151041474 GQCEDK(ub)DEEEKEEQEEEEGAAEPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQCEDKDEEEKEEQEEEEGAAEPR 24 2 O75808;A0A1B0GVE3;O75808-2;H3BR03 O75808 CAPN15 Calpain-15 1 7074800.0 2186100.0 2276000.0 2612700.0 True False 2994360.247131156 2175438.794274487 1995634.0702455505 1.0 0.7265120475596538 0.6664642546458905 21.513816369706667 -13.999999999999998 0.21305631691052573 2.601886640302282 0.6321265585291654 0.9994919457472466 0.003271950055230149 12.81998220878462 0.146279360509542 8.609459565189098 0.034822755759632756 1.0000000000000041e-14 13.999999999999998 -1.9697600817731162 GQCEDKDEEEK(ub)EEQEEEEGAAEPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQCEDKDEEEKEEQEEEEGAAEPR 24 2 O75808;A0A1B0GVE3;O75808-2;H3BR03 O75808 CAPN15 Calpain-15 1 12659400.0 3861600.0 3279000.0 5518800.0 True False 5062594.99578759 2789785.981441893 4947767.516067708 1.0 0.5510584954481205 0.97731845430744 22.271445643550198 -10.639510945796975 9.59627246251747 1.0000818867893069 0.7641884748777803 0.28980094772681697 0.17401989949751379 0.00030497667442702013 1.1456573385119185e-05 0.16855200157317118 0.05616468105521326 2.293448826485933e-11 10.639510945796975 -0.23589341191152657 GQCEDKDEEEK(ub)EEQEEEEGAAEPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQCEDKDEEEKEEQEEEEGAAEPR 24 2 O75808;A0A1B0GVE3;O75808-2;H3BR03 O75808 CAPN15 Calpain-15 1 7471400.0 3428800.0 2396500.0 1646100.0 True False 3319954.620830232 3353434.9475824037 1214937.0280585254 1.0 1.0100845736089608 0.3659498899279238 21.662732091393178 -6.903346136747205 0.9398887410489185 1.0243779080734399 0.2935524956902683 0.9881583019402217 0.03278724503130339 0.10898347849339078 0.16386159163040553 0.02598984116947412 0.06882877100662643 1.24926295911711e-07 6.903346136747205 -0.7308254123831716 down GQDEGK(ub)AQELEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQDEGKAQELEAK 13 1 O75683 O75683 SURF6 Surfeit locus protein 6 1 12628300.0 5439000.0 3607400.0 3581900.0 True False 8251360.644162307 2963631.285255153 2873935.894997458 1.0 0.35916879810021035 0.34829842239785236 22.976200607801196 GQDHCGIESEVVAGIPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQDHCGIESEVVAGIPR 17 0 P07858;R4GMQ5 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 20437200.0 2434900.0 9821300.0 8181000.0 False True 3192177.479605142 8356000.323127556 7334508.597693316 1.0 2.6176490425467054 2.297650630190074 21.606109434489735 -10.484820718043837 5.554281120982087 0.9979945924367954 2.4576498363683923 0.9651157106284055 0.13063880479575454 0.00324648613093692 0.0003011229516353762 0.12658053582899306 0.04216349294519855 3.274758529280922e-11 10.484820718043837 1.4596552439315968 GQDHCGIESEVVAGIPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQDHCGIESEVVAGIPR 17 0 P07858;R4GMQ5 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 7974800.0 3415400.0 0.0 4559400.0 False True 3306979.9964954425 0.0 3365156.3609319185 1.0 0.0 1.0175919916353071 21.657082888199405 -12.076035919428492 14.636278596108651 0.8841129972185768 0.5579163962358991 0.0 0.48922056065804226 0.0 0.0 0.0 0.1407082298263908 8.393905597195851e-13 12.076035919428492 -0.3261966009826778 GQDHCGIESEVVAGIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQDHCGIESEVVAGIPR 17 0 P07858;R4GMQ5 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 19585000.0 2434900.0 7348200.0 9801900.0 False True 3335148.3306983416 7023532.226752094 7486893.096467207 1.0 2.1059130000618134 2.244845612278821 21.669319496012626 -10.752259050438457 0.39842591986435677 5.559148944219203e-16 2.256784770937715 0.9994158057797887 0.013462136354961626 2.358585292024964 0.19245430061100427 2.301965906875089 0.035586182256452 1.769053428510919e-11 10.752259050438457 2.2567847709377147 GQDLLALIVAQHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQDLLALIVAQHR 13 0 Q86WJ1;Q86WJ1-2;Q86WJ1-4;A0A0A0MSH9;A0A494C1P7;Q86WJ1-3;Q86WJ1-5;A0A494C1F7;A0A0A0MRH8;A0A494C179 Q86WJ1 CHD1L Chromodomain-helicase-DNA-binding protein 1-like 0 1890480.0 540740.0 812400.0 537340.0 False True 708915.3765336093 691193.0867103966 481741.21132924163 1.0 0.9750008387321635 0.6795468504080366 19.435253897188304 -6.923614785531274 0.7974591964271405 1.0057094566253868 0.6277021446500679 0.9951275244111031 0.010158377440066407 0.09609136254850295 0.09493334739067938 0.008924413881379647 0.027731001373616008 1.192299095439165e-07 6.923614785531274 -0.3780073119753189 GQDLLALIVAQHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQDLLALIVAQHR 13 0 Q86WJ1;Q86WJ1-2;Q86WJ1-4;A0A0A0MSH9;A0A494C1P7;Q86WJ1-3;Q86WJ1-5;A0A494C1F7;A0A0A0MRH8;A0A494C179 Q86WJ1 CHD1L Chromodomain-helicase-DNA-binding protein 1-like 0 2807830.0 540740.0 825990.0 1441100.0 False True 740666.1909490419 789495.0306163356 1100741.8603861395 1.0 1.0659255684463302 1.4861510810635488 19.498463958711195 -6.934567817602901 0.7082910374155424 0.9945629705953163 1.5833969606227887 0.9973623764617973 0.011058548168749004 0.0903342336702206 0.06656199260874202 0.010364252973431918 0.037114622909397495 1.1626049893138535e-07 6.934567817602901 0.5888339900274724 GQDPLADRGEK(ub)DTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQDPLADRGEKDTAK 15 2 Q14764 Q14764 MVP Major vault protein 1 22008600.0 4527500.0 8717700.0 8763400.0 True False 5860938.000367372 8232552.3315258045 7168551.120077324 1.0 1.404647571943224 1.2231064583225395 22.482700145265863 -10.105475807735612 4.168807723718132 0.9999433091366488 1.31387701507748 0.7994275266669061 0.0741138495064833 10409498.027254518 8411115.079366134 4837.478865537877 0.025371141362262 7.843758111214007e-11 10.105475807735612 0.31393370594083114 GQDPLADRGEKDTAK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQDPLADRGEKDTAK 15 2 Q14764 Q14764 MVP Major vault protein 1 6305100.0 1487800.0 1981500.0 2835800.0 True False 1440570.6033805471 2772723.2833859897 2093018.9078235612 1.0 1.9247395975451094 1.4529096338020029 20.458208939055453 -10.274937348175275 5.015704064160534 0.9998409956634633 1.688824615673871 0.7397015817888688 0.19262377608884293 0.0003425715685293502 4.952187516535081e-05 0.18654958131447497 0.06216905640614975 5.309610357599558e-11 10.274937348175275 0.6889836200104078 GQEHVK(ub)TALENQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQEHVKTALENQK 13 1 Q12846-2;Q12846 Q12846-2 STX4 Syntaxin-4 1 7502700.0 2772900.0 2600000.0 2129800.0 True False 3635298.752801798 2212090.1347206207 1909428.7264842012 1.0 0.6085029828747137 0.5252467145960331 21.79364250058726 -13.999999999999991 0.21757376141367996 3.337645029194797 0.4796640541481152 0.9994955808548631 0.004648772709868298 12.934748242077271 0.14778686137457178 12.974817799142905 0.046824665253964386 1.0000000000000205e-14 13.999999999999991 -2.857980975046682 GQEHVK(ub)TALENQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQEHVKTALENQK 13 1 Q12846-2;Q12846 Q12846-2 STX4 Syntaxin-4 1 5076900.0 1942300.0 1751000.0 1383600.0 True False 1880642.7496612677 2450183.431344371 1021193.6528897237 1.0 1.3028436324685728 0.5430024671478175 20.84279438722174 -6.798550216309584 1.4617559353149354 1.1674047954642095 0.5328784514345238 0.8278901112636068 0.1295713641543444 0.2228458801494262 0.9401934010489525 0.06973701263496075 0.1623328897315383 1.590192803450387e-07 6.798550216309584 -0.6345263440296857 GQEHVK(ub)TALENQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQEHVKTALENQK 13 1 Q12846-2;Q12846 Q12846-2 STX4 Syntaxin-4 1 5937200.0 3076900.0 1561900.0 1298400.0 True False 4667882.251521057 1283166.741819601 1041770.670891063 1.0 0.27489269709009334 0.22317843826321793 22.15433673849086 -13.819876996680561 0.3763441909531743 9.999999985569076 0.2182895557896209 0.9997974763159894 0.005046864986493968 20.489743160342808 0.1993739363540392 148.33955172964065 0.014178574690348512 1.5139899884558693e-14 13.819876996680561 -9.781710429779455 GQEHVK(ub)TALENQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQEHVKTALENQK 13 1 Q12846-2;Q12846 Q12846-2 STX4 Syntaxin-4 1 6745500.0 2772900.0 2411300.0 1561300.0 True False 3798116.0648048916 2304760.7928972156 1192553.0959828447 1.0 0.6068168411845547 0.31398542741586966 21.856852562110152 -7.92178471925539 0.22808958228908266 1.1979703952346135 8.723764859585747e-14 0.9997622993632715 0.004333271294842125 0.11144942140908048 0.03786502735644978 0.06395244817632867 0.0947518096447651 1.1973339053176106e-08 7.92178471925539 -1.1979703952345262 down GQEHVK(ub)TALENQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQEHVKTALENQK 13 1 Q12846-2;Q12846 Q12846-2 STX4 Syntaxin-4 1 5409090.0 1942300.0 2549200.0 917590.0 True False 1615108.5084794078 2535466.95362342 1109453.826543198 1.0 1.5698431036132126 0.6869221607826996 20.623199662656017 -6.732468765387313 1.7144550515978583 1.3419837566734591 0.6872274015933084 0.5706005120900544 0.2395045754081111 0.33161623243875127 1.9107399262595328 0.11066009974209401 0.2738076495042818 1.851532052256649e-07 6.732468765387313 -0.6547563550801507 GQEHVK(ub)TALENQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQEHVKTALENQK 13 1 Q12846-2;Q12846 Q12846-2 STX4 Syntaxin-4 1 6925600.0 3076900.0 2152200.0 1696500.0 True False 3983107.704766511 2032428.1780641524 1387754.407559986 1.0 0.5102619182584451 0.34840996287880593 21.925463060583308 -13.999999999999998 0.15474261725438435 3.387051720709347 0.17969700021978663 0.999551189527652 0.005868487036683708 11.978739879804207 0.12411294918224276 8.587977462422572 0.15281626049854924 1.0000000000000041e-14 13.999999999999998 -3.20735472048956 GQELIYAGMPITEVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQELIYAGMPITEVFK 16 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 10941500.0 1869800.0 6174600.0 2897100.0 False True 2451325.907168958 5253373.748402291 2597335.8829455236 1.0 2.1430743798850576 1.0595636734183556 21.225130874581236 -6.6335661426092765 2.0676407409129154 1.7510824385885517 1.063977597903525 0.13058845753702053 0.489870662575233 0.5496457910395683 4.4826268887903575 0.19347483869194387 0.5425411144351164 2.325058354877023e-07 6.6335661426092765 -0.6871048406850266 GQELIYAGMPITEVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQELIYAGMPITEVFK 16 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 10161600.0 4805200.0 2007100.0 3349300.0 False True 4652661.556233502 2808545.496888226 2472017.8531537685 1.0 0.6036427672512344 0.5313126311201016 22.14962481575696 -13.999999999999998 0.2392401434555474 3.613879873511362 0.49910056919965456 0.9995237101694477 0.004496192547751474 13.596690057928313 0.15481157352986685 16.971661919371165 0.03550165806125892 1.0000000000000041e-14 13.999999999999998 -3.114779304311708 GQELIYAGMPITEVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQELIYAGMPITEVFK 16 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 16223100.0 1869800.0 7888400.0 6464900.0 False True 2561115.5894450527 7539864.4045495745 4938023.76879491 1.0 2.94397661535586 1.9280753235604218 21.288340936104127 -9.845629996632228 9.982190310235715 0.99999999863977 2.436025969458141 0.7270861514639755 0.41473996565551785 0.0 0.0 0.4015702420056827 0.13385674833253802 1.4268226778214232e-10 9.845629996632228 1.4360259708183714 GQEVETSVTYYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQEVETSVTYYR 12 0 D6RFH4;H3BUX2;O43169 D6RFH4 CYB5B Cytochrome b5 type B 0 5158900.0 1367600.0 2288600.0 1502700.0 False True 1792936.8438572402 1947149.8008929284 1347215.0189162411 1.0 1.086011371546095 0.7514012685566247 20.773893239538992 -6.838490272080423 1.2893578702054256 1.045768694371829 0.7407181627559392 0.9218369751882884 0.0396656357219442 0.17056484548078252 0.551454410285982 0.024128680182230702 0.05556829120163584 1.4504732636177024e-07 6.838490272080423 -0.3050505316158898 GQFAEHLLGAGFVSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQFAEHLLGAGFVSSR 16 0 Q9H2U1-3;Q9H2U1;Q9H2U1-2;E7EWK3;A0A0G2JQU7;A0A0G2JRP3 Q9H2U1-3 DHX36 ATP-dependent RNA helicase DHX36 0 5994140.0 1280800.0 2475140.0 2238200.0 False True 1754346.3723185475 2365780.130606567 1709583.257175945 1.0 1.3485251076615774 0.9744844485394047 20.742502186144744 -6.662056281538591 1.9654983030827788 1.2239623652553622 0.9760359915007705 0.24437440229238927 0.14832189698475587 0.47961955677879436 3.563950621222378 0.06092062613064071 0.16447153298866493 2.1774275746272662e-07 6.662056281538591 -0.2479263737545917 GQHVPGSPFQFTVGPLGEGGAHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQHVPGSPFQFTVGPLGEGGAHK 23 0 P21333-2;P21333;Q60FE5;H0Y5C6 P21333-2 FLNA Filamin-A 0 12564500.0 3401500.0 3804000.0 5359000.0 False True 4459399.440172855 3236458.027875864 4804502.08715787 1.0 0.7257609620524177 1.077387695723359 22.088418000764893 -6.69852213239249 1.835559551974354 0.8294746820962015 1.0763353579452926 0.410922666038383 0.11578955526014688 0.3985554085108725 2.6095024835548797 0.050338538719458155 0.12972205438018303 2.002063590391069e-07 6.69852213239249 0.2468606758490911 GQICWYQK(ub)PGVGLDAINDANLLEACIYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQICWYQKPGVGLDAINDANLLEACIYR 28 1 P14324;P14324-2;A0A087WVN4;A0A087X090 P14324 FDPS Farnesyl pyrophosphate synthase 1 375536000.0 23300000.0 88706000.0 263530000.0 True False 35347803.45816914 72875721.23685858 211443179.99069765 1.0 2.0616760903715066 5.981791209202607 25.07511723176489 -6.946714877263798 0.5938159190942831 0.9551752608430506 7.286843962809828 0.9989176145161813 0.07048740548375339 0.08483232733345535 0.04163294059762466 0.07279253084185063 0.32878985823270857 1.1305378911002441e-07 6.946714877263798 6.331668701966777 GQICWYQK(ub)PGVGLDAINDANLLEACIYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQICWYQKPGVGLDAINDANLLEACIYR 28 1 P14324;P14324-2;A0A087WVN4;A0A087X090 P14324 FDPS Farnesyl pyrophosphate synthase 1 242243000.0 23300000.0 24723000.0 194220000.0 True False 30162309.31166424 23347143.31673639 158873952.8654878 1.0 0.7740502584033804 5.267300697166737 24.846243553857338 -6.895060689680741 0.9919455336991304 0.787038482580803 5.6943924649953175 0.9839452540942789 0.2618965698447642 0.11513370924472192 0.19862217854595354 0.1997097183209608 0.5078706022926519 1.2733251301132716e-07 6.895060689680741 4.907353982414515 up GQILMPNIGYGSNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQILMPNIGYGSNK 14 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 19363500.0 3463200.0 7455300.0 8445000.0 False True 4540288.737676508 6342998.300531792 7571192.410160147 1.0 1.3970473392795324 1.667557472134405 22.11435261731795 -7.811290032865664 0.08335267261118176 2.9637265660701446e-15 2.8444176481265333 0.9999967834436655 0.0004916589357431017 0.13306332040128677 0.011276355440331618 0.16993872982566935 0.20307994930724263 1.544222823954785e-08 7.811290032865664 2.84441764812653 GQILMPNIGYGSNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQILMPNIGYGSNK 14 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 18603700.0 3463200.0 6008200.0 9132300.0 False True 4743638.6294609625 5742737.857539522 6975438.8256223155 1.0 1.2106187477843546 1.4704827602803632 22.177562678840843 -6.968300092488374 0.2959867893102431 0.9527264533663742 1.7364715137953841 0.9999659198118742 0.0011233236516167307 0.07685825407374665 0.010994028164259085 0.004399406200776664 0.023407141840865838 1.0757216454851643e-07 6.968300092488374 0.7837450604290099 GQILMPNIGYGSNKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQILMPNIGYGSNKK 15 1 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 26159600.0 4134800.0 8720800.0 13304000.0 False True 5420762.841460163 7419690.633412159 11927429.700979337 1.0 1.3687539651547558 2.2003231002385095 22.370064459676417 -6.957631612486412 0.46762355577791265 0.9775210388501426 2.625509884523931 0.9996720046192413 0.009091994299869614 0.0805583436545175 0.024341955685189428 0.011447117930959124 0.06864630291382498 1.1024740796081474e-07 6.957631612486412 1.6479888456737886 up GQILMPNIGYGSNKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQILMPNIGYGSNKK 15 1 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 15499500.0 5053100.0 2427100.0 8019300.0 False True 4892692.106427101 3396253.6871592966 5918804.756156816 1.0 0.6941482548427552 1.2097235279493268 22.22219706719692 -6.745954774602818 1.6645394205877118 0.8192918536511921 1.2104585963271335 0.6315363630809174 0.12850367182840372 0.30713495262255563 1.6729270079268252 0.06101599711163619 0.1487809883524885 1.7949205317342537e-07 6.745954774602818 0.3911667426759414 GQILMPNIGYGSNKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQILMPNIGYGSNKK 15 1 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 21671200.0 4134800.0 7830600.0 9705800.0 False True 5663547.298768537 7484618.199668618 7413489.93722557 1.0 1.3215424547255126 1.3089834949974788 22.43327452119931 -10.130594242310309 4.594670497382307 0.9999680817175846 1.3152629748676208 0.9988112059551844 0.0051271738598799325 3579766.931072273 0.05890329966305305 1208.8293393920856 0.0017551679839404352 7.402966049612732e-11 10.130594242310309 0.3152948931500362 GQILMPNIGYGSNKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQILMPNIGYGSNKK 15 1 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 11247100.0 5053100.0 3771300.0 2422700.0 False True 4201876.540285899 3750983.258355559 2929275.368700837 1.0 0.8926924012147055 0.6971350396938427 22.002602342631196 -6.96182236202623 0.40894742360130193 1.0097445823526032 0.5728380363927258 0.9998319139043017 0.0016255366781438366 0.07905653219575326 0.018773050507269948 0.002517482357829271 0.016333165728705565 1.0918868558374068e-07 6.96182236202623 -0.43690654595987743 GQILMPNIGYGSNKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQILMPNIGYGSNKK 15 1 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 16062200.0 4961000.0 5342600.0 5758600.0 False True 6422112.295929876 5045279.613477158 4710593.888225714 1.0 0.785610618592685 0.7334960323274219 22.61461646132101 -13.999999999998906 0.19865606214957962 2.185722198524861 0.6991987192080467 0.9994869207575778 0.002612297348097233 12.504577222016872 0.14133126356773174 5.757920944778403 0.03351927517086142 1.0000000000025196e-14 13.999999999998906 -1.4865234793168145 GQIQITINGFSISNGLATTQINNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQIQITINGFSISNGLATTQINNK 24 0 O15294;O15294-3;O15294-2;O15294-4 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 0 49610000.0 16134000.0 15162000.0 18314000.0 False True 24476457.55339488 12456222.638753306 14694229.872688664 1.0 0.508906266831314 0.6003413623329074 24.544891437929913 -10.084850603457301 5.326569860033249 1.0000059445587115 0.5546238145817487 0.9693579844390706 0.037328221428352945 2.6351826779926294e-06 4.527334785495749e-07 0.03614337734911084 0.012047631661090012 8.225255486370444e-11 10.084850603457301 -0.4453821299769628 GQIQITINGFSISNGLATTQINNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQIQITINGFSISNGLATTQINNK 24 0 O15294;O15294-3;O15294-2;O15294-4 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 0 37814000.0 16134000.0 11180000.0 10500000.0 False True 20885781.048686296 10557823.171990167 8589107.739098048 1.0 0.5055029135553563 0.41124187403268303 24.316017760022362 -13.999999999999861 0.23306047989341666 4.166478731447651 0.36672582611461585 0.9995141227080109 0.005691608929450122 13.388530066048617 0.1528361345087999 19.651956366897114 0.048015256706937855 1.000000000000319e-14 13.999999999999861 -3.7997529053330346 GQIQVILGPMFSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQIQVILGPMFSGK 14 0 K7ES52;P04183;K7ERV3;K7ERJ1;K7ENW5 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 0 34367060.0 6299760.0 22637000.0 5430300.0 False True 8259046.366962627 19259647.838334907 4868424.647115763 1.0 2.3319457214063197 0.589465711996746 22.97754377940964 -6.702411792243289 1.8221373878964122 1.8251140303172435 0.5943843397200057 0.4290955564260208 0.5619855766038192 0.39052436636823784 2.5224101837494617 0.24589029246151656 0.630519926747081 1.9842126211350397e-07 6.702411792243289 -1.2307296905972378 GQIQVILGPMFSGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 GQIQVILGPMFSGK 14 0 K7ES52;P04183;K7ERV3;K7ERJ1;K7ENW5 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 0 90871300.0 37670000.0 31789400.0 21411900.0 False True 36474186.469515465 44483073.19953099 15803481.046768915 1.0 1.2195768433850944 0.43327850670438417 25.120372464438745 -6.832164967039042 1.318021026063014 1.1171721730370148 0.4111424452820054 0.9101523285718133 0.09929655943720452 0.17816868112798837 0.6045243922739046 0.0591345122494697 0.1360967118747774 1.4717533497830957e-07 6.832164967039042 -0.7060297277550094 down GQIQVILGPMFSGK ddPTM_RPMI8226_Bortezomib_8h_R1 2 GQIQVILGPMFSGK 14 0 K7ES52;P04183;K7ERV3;K7ERJ1;K7ENW5 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 0 983257600.0 311157600.0 385678000.0 286422000.0 False True 472048827.86762315 316850747.58403224 229810566.1567777 1.0 0.6712245193263923 0.4868364300254625 28.814360856141665 -11.046032361797172 0.09758512422584732 2.009990079547567 3.0875033194032813e-13 0.9999006134593447 0.0021159158539990953 3.4178458531575404 0.059691081392922805 1.08716203863932 0.3159642018843005 8.99430557252784e-12 11.046032361797172 -2.0099900795472583 GQIQVILGPMFSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQIQVILGPMFSGK 14 0 K7ES52;P04183;K7ERV3;K7ERJ1;K7ENW5 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 0 64105760.0 6299760.0 24017000.0 33789000.0 False True 8628951.516612671 22955849.526401717 25808734.106298804 1.0 2.6603289498389864 2.9909467050094314 23.04075384093253 -10.163560728331815 0.36878081848827304 2.6748157100787176e-15 3.043642673415597 0.9989701225102744 0.02795617234208542 1.544872531756374 0.16861141136226154 1.6843383650663388 0.09205021428323586 6.86181921408261e-11 10.163560728331815 3.043642673415594 GQIQVILGPMFSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GQIQVILGPMFSGK 14 0 K7ES52;P04183;K7ERV3;K7ERJ1;K7ENW5 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 0 83521800.0 37670000.0 19938200.0 25913600.0 False True 31324274.06395471 19830788.95917717 31332013.949051056 1.0 0.6330805597821257 1.000247089049232 24.90077773987302 -10.94063320180441 10.617397638448514 1.0429464494370817 0.816663824415679 0.2494952785993113 0.1498951078888461 0.08963776518370899 0.0005012057179082845 0.08537474986954918 0.048378438044288756 1.1464808320882834e-11 10.94063320180441 -0.22628262502140273 GQIQVILGPMFSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GQIQVILGPMFSGK 14 0 K7ES52;P04183;K7ERV3;K7ERJ1;K7ENW5 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 0 859685600.0 311157600.0 402847000.0 145681000.0 False True 402799647.0332663 380428210.319027 119168552.81328996 1.0 0.9444601382374307 0.2958506882789003 28.585487178234114 -6.923790394311982 0.7961165976743216 1.0124524778664314 0.1815622361268389 0.9951704971362378 0.022214198155757616 0.09599279821438868 0.0944337130052797 0.01953451874151858 0.06081436361081545 1.1918170817978568e-07 6.923790394311982 -0.8308902417395926 down GQLCELSCSTDYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQLCELSCSTDYR 13 0 E9PKG1;Q99873-2;Q99873-3;Q99873;Q99873-5 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 0 16573000.0 0.0 7169500.0 9403500.0 False True 0.0 6099838.546492116 8430516.02474138 0.0 GQLCELSCSTDYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQLCELSCSTDYR 13 0 E9PKG1;Q99873-2;Q99873-3;Q99873;Q99873-5 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 0 13892700.0 0.0 5554100.0 8338600.0 False True 0.0 5308701.497047416 6369194.418857719 0.0 GQLLIFGATNWDLIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQLLIFGATNWDLIGR 16 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 186470000.0 58169000.0 56786000.0 71515000.0 False True 88246625.72352964 46652094.62895688 57380028.90386204 1.0 0.528655846571568 0.6502234893788411 26.39503777947922 -10.155197370685052 7.8065029768156835 1.0000001043332523 0.5894396679752205 0.9383000211447026 0.049629782351790754 9.011370094491873e-08 9.72294156831959e-09 0.0480538423039109 0.01601794337703203 6.995240161116644e-11 10.155197370685052 -0.41056043635803174 GQLLIFGATNWDLIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQLLIFGATNWDLIGR 16 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 125227000.0 58169000.0 30185000.0 36873000.0 False True 75300917.1824119 28505178.215252504 30162492.348929737 1.0 0.37855021269130684 0.40055942845772957 26.16616410157167 -10.281101712579172 6.798565627378047 1.0000079098635837 0.3895548205746063 0.9990260110327028 0.008985224711092447 1.0772630951325006e-06 1.1391839867672906e-07 0.008700019068443232 0.0028999688056660262 5.234778227438727e-11 10.281101712579172 -0.6104530892889775 GQMEVWDVKNYK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQMEVWDVKNYK 12 1 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;Q9BY44-2;H7C5R5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 1 18994100.0 1813300.0 5011800.0 12169000.0 True False 2750908.66998704 4117405.1326278714 9763791.816137837 1.0 1.496743667846766 3.549296973273866 21.391476812379246 -6.944129055891383 0.6199599880717419 0.9775349166442935 4.177239059186461 0.9986562514001699 0.040449780620787766 0.08593238662020322 0.04640353916193308 0.040737491107680254 0.17370567934355083 1.1372892762529497e-07 6.944129055891383 3.199704142542168 up GQMEVWDVKNYK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQMEVWDVKNYK 12 1 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;Q9BY44-2;H7C5R5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 1 16102100.0 1813300.0 5132000.0 9156800.0 True False 2347352.5954867257 4846399.6886094315 7490356.356702191 1.0 2.064623652163567 3.1909804990967103 21.162603134471695 -6.97041154229703 0.24815951976586478 0.6343558232446153 4.654160880430339 0.999985417042607 0.00341619400541534 0.07616938788875081 0.008550977523163776 0.025438534476240005 0.10827829582533688 1.0705044025301643e-07 6.97041154229703 4.0198050571857245 GQNRPTNVK(ub)ENTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQNRPTNVKENTIK 14 2 Q9BX40-2;Q9BX40;Q5TBQ1;Q5TBP9;Q5TBQ0;Q9BX40-3 Q9BX40-2 LSM14B Protein LSM14 homolog B 1 4608400.0 2261600.0 1329100.0 1017700.0 True False 2189806.745937249 1859816.5611649367 751133.8396544311 1.0 0.8493062525336798 0.3430137572861215 21.062372124547803 -6.948881034785141 0.5709983786100359 1.0062787790659333 0.16138351964691414 0.9991105034674423 0.008380795782268028 0.08393824384497289 0.03784643464838978 0.008868862467486084 0.0421944740905702 1.124913076426976e-07 6.948881034785141 -0.8448952594190192 down GQNRPTNVK(ub)ENTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQNRPTNVKENTIK 14 2 Q9BX40-2;Q9BX40;Q5TBQ1;Q5TBP9;Q5TBQ0;Q9BX40-3 Q9BX40-2 LSM14B Protein LSM14 homolog B 1 3874270.0 1301600.0 1611500.0 961170.0 True False 1782836.694417412 1540298.6014821336 734161.441917524 1.0 0.8639594452510784 0.4117939933682093 20.765743129301015 -6.949126759420391 0.5683480988527091 1.0056752018798456 0.24815650167428482 0.9991309729376588 0.00741192720108832 0.08383826856789804 0.03742801406738268 0.007867358689782009 0.03765915449407581 1.1242767785173779e-07 6.949126759420391 -0.7575187002055608 down GQNRPTNVK(ub)ENTIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQNRPTNVKENTIK 14 2 Q9BX40-2;Q9BX40;Q5TBQ1;Q5TBP9;Q5TBQ0;Q9BX40-3 Q9BX40-2 LSM14B Protein LSM14 homolog B 1 4389580.0 2261600.0 1764600.0 363380.0 True False 1880620.6058677987 1755093.7495543251 439361.07792071305 1.0 0.9332524295853123 0.23362557899761663 20.84277739998208 -6.925439485973851 0.7833192155882576 1.0126270064083807 0.10536476661128437 0.995563529350826 0.02308676876675627 0.09507591567166077 0.08979398297999575 0.020488130339724617 0.06496367357709566 1.1873001263678768e-07 6.925439485973851 -0.9072622397970963 down GQPAIIDGELYNEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQPAIIDGELYNEVK 15 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 21538800.0 2437000.0 11938000.0 7163800.0 False True 3194930.599941572 10156896.933959544 6422558.696021929 1.0 3.179066529377912 2.0102341804042263 21.6073531627163 -10.296861817589223 5.867013307973276 0.9998805064701443 2.5946503548910753 0.7127915072667121 0.47717380830739026 0.0007458846140552099 8.939146512374337e-05 0.46205495064328767 0.15400718440173788 5.04821894607434e-11 10.296861817589223 1.5947698484209312 GQPAIIDGELYNEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQPAIIDGELYNEVK 15 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 21702000.0 7954000.0 0.0 13748000.0 False True 7701504.623799472 0.0 10146986.368840653 1.0 0.0 1.3175329840722376 22.876708898409202 -6.703768817929599 1.8175117623139336 0.3813466912815412 1.3138928941686436 0.4354564359045735 0.42182832504571066 0.3877272614886564 2.4925995766719566 0.1849807460228255 0.47350647165339926 1.9780222935994874e-07 6.703768817929599 0.9325462028871024 GQPAIIDGELYNEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQPAIIDGELYNEVK 15 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 23384700.0 2437000.0 9308700.0 11639000.0 False True 3338024.7574487086 8897410.854245571 8890107.912729349 1.0 2.66547179867113 2.663283995390185 21.670563224239192 -10.194585553519946 4.219357520207562 0.9993349720663143 2.664377897142457 0.9999987040391791 0.0008931673259279842 104590.64952868453 0.8337496297944904 675.8881931596214 0.0003057548771464732 6.388728706629898e-11 10.194585553519946 1.665042925076143 GQPIYIQFSNHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQPIYIQFSNHK 12 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EKJ7;K7ES59 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 600534000.0 163390000.0 87564000.0 349580000.0 False True 158203273.8851641 122528761.8402276 258014510.8247975 1.0 0.77450206200643 1.6309050027124212 27.237204214592403 -6.836720419865296 1.297587777333777 0.8799453329512125 1.6572841037271318 0.9186584559780718 0.10337173717681072 0.17266488268185226 0.566149040133351 0.06250004773373455 0.14388237087077266 1.4563963442794444e-07 6.836720419865296 0.7773387707759193 GQPIYIQFSNHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQPIYIQFSNHK 12 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EKJ7;K7ES59 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 613000000.0 225720000.0 170150000.0 217130000.0 False True 342433742.34240115 139785403.11198232 174214160.3285402 1.0 0.4082115335824886 0.5087529024938864 28.3512496264676 -10.065890790663094 5.32474429173337 1.0000057506888547 0.45848221803803596 0.974797715020921 0.04104584198118377 2.802227527837241e-06 4.91484008226663e-07 0.03974288764867144 0.013247488535029847 8.592295594639088e-11 10.065890790663094 -0.5415235326508188 GQPIYIQFSNHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQPIYIQFSNHK 12 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EKJ7;K7ES59 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 333463000.0 163390000.0 81473000.0 88600000.0 False True 135866024.40428883 81034088.77787578 107125850.35988544 1.0 0.5964264365073879 0.7884668063968452 27.01760949002668 -10.059440147419249 4.936858898345189 1.0000069905151854 0.6924466214496471 0.7737429848294464 0.07840015271596341 6.032338314420738e-06 1.1493418180313807e-06 0.07591234599468785 0.025303540482867003 8.720870802623427e-11 10.059440147419249 -0.3075603690655383 GQPIYIQFSNHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQPIYIQFSNHK 12 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EKJ7;K7ES59 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 730940000.0 225720000.0 298100000.0 207120000.0 False True 292198989.60638875 281510472.94904 169426285.23066574 1.0 0.9634204188325672 0.5798318654657023 28.122375948560048 -6.925433054254933 0.7833756419382328 1.00692492415667 0.5095219682480805 0.9955618806298625 0.012659976582049901 0.09507964804716192 0.08981379332339326 0.01123453036004176 0.03561942034340062 1.1873177099144074e-07 6.925433054254933 -0.4974029559085895 GQPLGPAGVQVSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQPLGPAGVQVSLR 14 0 A0A0G2JN29;A0A087X117;Q15155;Q5JPE7-2;Q5JPE7;J3KN36;P69849 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 26903200.0 7717700.0 9419300.0 9766200.0 False True 10117979.43831311 8013977.156143835 8755687.308005454 1.0 0.7920531174236051 0.865359270730562 23.270417876637588 -10.648416287032932 9.174074493941154 1.0001019263523208 0.8287061952251673 0.8792294486300212 0.029927111768047025 6.242692906696068e-05 2.3924034116335704e-06 0.02899390956531799 0.00965893378981118 2.2468998381949418e-11 10.648416287032932 -0.17139573112715345 GQPLGPAGVQVSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQPLGPAGVQVSLR 14 0 A0A0G2JN29;A0A087X117;Q15155;Q5JPE7-2;Q5JPE7;J3KN36;P69849 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 39450000.0 0.0 19999000.0 19451000.0 False True 0.0 16430022.197099792 15606501.324323842 0.0 GQPLGPAGVQVSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQPLGPAGVQVSLR 14 0 A0A0G2JN29;A0A087X117;Q15155;Q5JPE7-2;Q5JPE7;J3KN36;P69849 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 27032300.0 7717700.0 8355600.0 10959000.0 False True 10571142.253000358 7986421.963725794 8370709.907689748 1.0 0.7554928098199648 0.7918453566655892 23.33362793816048 -10.879559550832758 10.974665815532047 1.0107882301348199 0.7736690832427771 0.9810189322949073 0.014840865103733652 0.0038206525583596817 4.192932414886805e-05 0.014014562435265583 0.004789868615839265 1.3195943553883805e-11 10.879559550832758 -0.23711914689204283 GQPLGPAGVQVSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQPLGPAGVQVSLR 14 0 A0A0G2JN29;A0A087X117;Q15155;Q5JPE7-2;Q5JPE7;J3KN36;P69849 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 8151100.0 0.0 4171600.0 3979500.0 False True 0.0 4149126.762802236 4811595.0508709205 0.0 GQPLGPAGVQVSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQPLGPAGVQVSLR 14 0 A0A0G2JN29;A0A087X117;Q15155;Q5JPE7-2;Q5JPE7;J3KN36;P69849 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 30122000.0 0.0 18602000.0 11520000.0 False True 0.0 17566782.347527817 9423478.205181869 0.0 GQPSNK(ub)EDVDDLVSQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQPSNKEDVDDLVSQLR 17 1 P12270 P12270 TPR Nucleoprotein TPR 1 6143700.0 2111500.0 2134600.0 1897600.0 True False 2768196.9477950837 1816126.0006056323 1701254.5550645199 1.0 0.6560682042700061 0.6145713571498582 21.40051515879426 -13.999999999945919 0.2983332126376806 4.107372413681259 0.6041836678507395 0.9996461089890275 0.003249664975239496 16.480501319031095 0.1734154377555711 31.58157443152087 0.015104848697937297 1.0000000001245266e-14 13.999999999945919 -3.5031887458305193 GQPSNK(ub)EDVDDLVSQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQPSNKEDVDDLVSQLR 17 1 P12270 P12270 TPR Nucleoprotein TPR 1 10503600.0 3267800.0 3491800.0 3744000.0 True False 3164065.477703285 4886093.949496451 2763334.082407579 1.0 1.5442455233395305 0.873349209073073 21.59334802481768 -6.690946594237025 1.86337660128407 1.34090825682289 0.8756608606522915 0.37475338553029147 0.23013376024650933 0.4146148127933808 2.791974462014143 0.09878179751983154 0.25689743125622244 2.037292590848737e-07 6.690946594237025 -0.4652473961705985 GQPSNK(ub)EDVDDLVSQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQPSNKEDVDDLVSQLR 17 1 P12270 P12270 TPR Nucleoprotein TPR 1 8977300.0 3267800.0 3460800.0 2248700.0 True False 2717320.488085779 3442155.9834849853 2718892.7731859405 1.0 1.2667464138209983 1.0005786159958148 21.373753300251956 -10.419628831250488 3.1180779826944964 0.99793228648982 1.1336625148327324 0.25163037722822623 0.10866255004590986 55016544.95019711 60782482.84511962 986244.6460269578 0.03825578509379385 3.805144631759521e-11 10.419628831250488 0.13573022834291237 GQPSNK(ub)EDVDDLVSQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQPSNKEDVDDLVSQLR 17 1 P12270 P12270 TPR Nucleoprotein TPR 1 15241400.0 8455400.0 6786000.0 0.0 True False 10945681.980851742 6408353.134626587 0.0 1.0 0.5854686026724777 0.0 23.38385850998129 -7.688306450193904 0.6505312003363544 0.9997810046054604 1.4967470299818438e-15 0.9874278891846434 0.04599739304192077 0.12038066798272337 0.15057721477546768 0.04273785433466096 0.07780150823004076 2.0497153326085646e-08 7.688306450193904 -0.9997810046054589 down GQQIGK(ub)VVQVYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQQIGKVVQVYR 12 1 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 1 7828500.0 1145000.0 2224900.0 4458600.0 True False 1501106.088195772 1892953.5925922724 3997266.841911188 1.0 1.2610391813595765 2.6628809737995485 20.517594509977265 -6.938224864767902 0.6758739615403948 0.9836770419598695 3.0219590813099697 0.997922057802475 0.033284887099900795 0.08858583691164883 0.05836753285530768 0.031980151077635424 0.1216275421340543 1.152856188610677e-07 6.938224864767902 2.0382820393501 up GQQIGK(ub)VVQVYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQQIGKVVQVYR 12 1 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 1 15177400.0 2383900.0 2607500.0 10186000.0 True False 2308224.3993808846 3648688.3479328644 7517981.026550107 1.0 1.5807338094647647 3.257040792293241 21.13835205506533 -6.952314833284883 0.5328332326927662 0.9740883067185382 3.9401527783944954 0.9993705980856579 0.02400742774141884 0.08256948491713051 0.03221802529600237 0.026673311063518845 0.13867390271466923 1.1160538930261044e-07 6.952314833284883 2.966064471675957 GQQIGK(ub)VVQVYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQQIGKVVQVYR 12 1 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 1 10489700.0 2383900.0 3229000.0 4876800.0 True False 1982318.4746764437 3211604.736093681 5896516.332224477 1.0 1.6201255131912558 2.9745555053594064 20.918757330499606 -6.958286472161179 0.45894512702050383 0.960102169123805 3.689082104385415 0.9997012744152406 0.014250047398314734 0.08031898723054844 0.023436555370779297 0.018361944195629247 0.11190266833272866 1.100812944582465e-07 6.958286472161179 2.72897993526161 GQQQETETFYLTK(ub)LQEYLSGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQQQETETFYLTKLQEYLSGR 21 1 E7EQN5;P98171;P98171-2;A0A0B4J1X7;E9PCM6;H7C120 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 1 46443100.0 8189100.0 11794000.0 26460000.0 True False 10600951.381293964 11137653.532240774 21644551.502527066 1.0 1.0506277344025796 2.04175556740315 23.33769040932861 -6.9174982391004045 0.843077636017877 0.976098216167905 2.192733177745477 0.9934572296734945 0.03879365664040188 0.09966610205984848 0.11340831245099824 0.032989287540764224 0.09657347463382292 1.2092100858220683e-07 6.9174982391004045 1.216634961577572 up GQQVK(ub)VVSQLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQQVKVVSQLLR 12 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 15901100.0 2099100.0 5551800.0 8250200.0 True False 2032465.2194892503 7768662.6922545275 6089225.119305283 1.0 3.822285674441582 2.9959799857413936 20.954799233752542 -10.168343733165171 5.8019267331116176 0.9999639712420907 3.4091328300915604 0.9189225354226371 0.33733788481267524 0.00015721532299878735 2.253627841096986e-05 0.32663081190681087 0.10887533416032295 6.78666272697213e-11 10.168343733165171 2.40916885884947 GQQVK(ub)VVSQLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQQVKVVSQLLR 12 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 32613500.0 2359300.0 3288200.0 26966000.0 True False 3579230.5879338356 2701395.019176135 21636158.28038231 1.0 0.7547418230842611 6.044918802750875 21.771218060089513 -6.896026770084037 0.9860110243060746 0.7554411120788483 6.557564489319238 0.9844848104884087 0.3036849993627621 0.11439055003924178 0.19435657634293585 0.23260618073741224 0.5940161471176316 1.2704957889307347e-07 6.896026770084037 5.802123377240389 up GQQVK(ub)VVSQLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQQVKVVSQLLR 12 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 9787800.0 2099100.0 3405500.0 4283200.0 True False 1745494.6558971982 3387153.8955611717 5178797.316720787 1.0 1.940512326472949 2.966951115676057 20.73520450918682 -6.970004777105185 0.2580749049296717 0.7049682548653021 4.232871731622503 0.9999824190778405 0.003368032074297415 0.07630119288943753 0.009024739767032417 0.02169654913398777 0.09712839736549284 1.0715075189209714e-07 6.970004777105185 3.527903476757201 GQQVK(ub)VVSQLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQQVKVVSQLLR 12 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 45771300.0 2359300.0 0.0 43412000.0 True False 3054160.358755767 0.0 35511461.44473567 1.0 0.0 11.627241949798165 21.542344382181962 -6.885976954829354 1.0459177404992754 0.3136794118785831 12.551785232922995 0.9781947486973067 0.7769144559506779 0.1224667446663789 0.241416810927195 0.5687696026521846 1.398858428164041 1.3002385713684996e-07 6.885976954829354 12.238105821044412 up GQSDIAITK(ub)DMFEEALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQSDIAITKDMFEEALR 17 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 7210200.0 1929500.0 3581500.0 1699200.0 True False 2529593.1853045807 3047154.160577658 1523383.0838773367 1.0 1.204602454766164 0.6022245366279759 21.270473955534214 -6.81506778598932 1.3932244145979171 1.1108566802085302 0.5904286036319747 0.8726318070451213 0.08925711674537729 0.19996623289020019 0.7640004778562568 0.05036221782177723 0.11624870095997478 1.5308485035938346e-07 6.81506778598932 -0.5204280765765555 GQSDIAITK(ub)DMFEEALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQSDIAITKDMFEEALR 17 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 25578000.0 10235000.0 15343000.0 0.0 True False 15527243.27872794 12604921.774593854 0.0 1.0 0.811793925574824 0.0 23.888298379246656 -7.23262298635541 0.8662122842272437 0.9896418145863147 3.067637985721582e-16 0.9890116314032885 0.04548385676828994 0.09644325759449864 0.1387771298308322 0.038466891363852215 0.0676475565719067 5.8529796433905865e-08 7.23262298635541 -0.9896418145863144 down GQSDIAITK(ub)DMFEEALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQSDIAITKDMFEEALR 17 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 11128100.0 1929500.0 4573800.0 4624800.0 True False 2642888.292776891 4371714.3924660105 3532517.49074583 1.0 1.6541427060742837 1.3366124858172506 21.333684017057106 -10.051132057031397 4.403097899727189 0.9999704400749632 1.4953775957889026 0.7644397797963846 0.12963116979291814 29932635.13975275 0.7169563738954965 9979.13852852373 0.0443761973769282 8.889307773085241e-11 10.051132057031397 0.49540715571393945 GQSEDPGSLLSLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQSEDPGSLLSLFR 14 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5GZI0 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 7166400.0 1314600.0 2790500.0 3061300.0 False True 1723453.330604511 2374168.2772838073 2744546.042063141 1.0 1.3775645879839717 1.5924690232838945 20.716870801816977 -10.460898284764662 0.10362750028804871 8.013314876483414e-18 2.1382123846769856 0.9999002379766865 0.00244601939421906 2.342968218882116 0.055635434997831926 0.9118662781033973 0.3244808598077369 3.460204090793161e-11 10.460898284764662 2.1382123846769856 GQSEDPGSLLSLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQSEDPGSLLSLFR 14 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5GZI0 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 5456600.0 2298200.0 1519600.0 1638800.0 False True 2225244.89897108 2126384.2046093117 1209549.1170538298 1.0 0.9555731171847738 0.5435577529525435 21.0855326897126 -6.927456400822246 0.7673908023487457 1.0068922768992825 0.46420517804821987 0.9960140939868382 0.012974002780087266 0.09398055649834906 0.08431173471555384 0.011645724548535519 0.03781521475089209 1.1817989483513864e-07 6.927456400822246 -0.5426870988510626 GQSEDPGSLLSLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQSEDPGSLLSLFR 14 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5GZI0 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 11820500.0 1314600.0 3406000.0 7099900.0 False True 1800643.1457292063 3255511.65786419 5423049.847030426 1.0 1.8079715936973209 3.0117293700825183 20.78008086333987 -6.96536979905149 0.3516479127555551 0.8858549033349079 3.974568148088452 0.9999205666797637 0.0073668002594989785 0.07783569219895727 0.014418730738699075 0.016455504494826353 0.103354206783397 1.0830043498268735e-07 6.96536979905149 3.088713244753544 GQSEEIQK(ub)K(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQSEEIQKKR 10 2 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 2 2100970.0 272880.0 349790.0 1478300.0 True False 357748.322573679 297602.69547074096 1325339.6968549127 1.0 0.8318772631266471 3.704670611228251 18.44858547683164 -6.89300963949719 1.0043894950113248 0.8565934424818584 3.9668523860461082 0.982756408915463 0.17286436742166378 0.11673593585293202 0.20784634006662922 0.1305903295520705 0.3293032298512291 1.279352907629051e-07 6.89300963949719 3.11025894356425 up GQSEEIQK(ub)K(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQSEEIQKKR 10 2 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 2 2420930.0 272880.0 861850.0 1286200.0 True False 373771.1103047202 823770.6172431741 982426.0501204982 1.0 2.2039440570235294 2.628416223285868 18.51179553835453 -9.973638223305889 0.2580335493928588 2.544261469590321e-10 2.850132262864735 0.9990575748954258 0.02117361042691256 1.4195490757605822 0.11584151125824607 1.2179394886870152 0.18244925529486697 1.0625803410256238e-10 9.973638223305889 2.850132262610309 GQSPLDLCPDPNLCK(ub)ALAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQSPLDLCPDPNLCKALAK 19 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 246465000.0 55635000.0 78150000.0 112680000.0 True False 72938023.77010639 66490324.62631414 101020954.50288278 1.0 0.9116003037851043 1.385024563063171 26.120167775104488 -6.858442071898779 1.1935487661240156 0.9522207837050599 1.4072807097109932 0.9517199682513309 0.045160865897787617 0.14841826969707209 0.4026423687329418 0.0295289482385545 0.06881451776725785 1.385344956982813e-07 6.858442071898779 0.45505992600593326 GQSPLDLCPDPNLCK(ub)ALAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQSPLDLCPDPNLCKALAK 19 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 164035000.0 101790000.0 42056000.0 20189000.0 True False 98558732.16702889 58849180.119142696 14900895.24298254 1.0 0.5970975764928688 0.15118797609662613 26.554480361923485 -7.633523381585427 0.42406028055686956 1.0350075617506547 6.866245319043687e-27 0.9980668663531287 0.015242371659044346 0.11968426333218547 0.06444207369389192 0.025066767937904674 0.07325756419404476 2.3252872934766422e-08 7.633523381585427 -1.0350075617506547 down GQSPLDLCPDPNLCK(ub)ALAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQSPLDLCPDPNLCKALAK 19 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 500968500.0 92411500.0 250767000.0 157790000.0 True False 140195001.6856052 206015669.5984864 126602737.3381861 1.0 1.469493684664219 0.9030474397518075 27.06285967355489 -6.686677715030063 1.8785037255340549 1.295265597641384 0.9050972239609948 0.3547360575680585 0.1987006334311987 0.42388281832565095 2.8974698776789656 0.08470760712275911 0.2214896618226438 2.0574168151162407e-07 6.686677715030063 -0.39016837368038926 GQSPLDLCPDPNLCK(ub)ALAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQSPLDLCPDPNLCKALAK 19 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 340518800.0 55635000.0 89589000.0 195294800.0 True False 76204762.97934297 85630661.74879485 149170190.46265966 1.0 1.1236917274056346 1.957491692521839 26.18337783662738 -6.933423825187143 0.7181330210985664 0.9887894827641157 2.1446134415329845 0.9971694139987529 0.02262311331638442 0.0908985029602456 0.0692540540665076 0.021047844337442074 0.0740754334917066 1.1656714905078297e-07 6.933423825187143 1.1558239587688688 GQSPLDLCPDPNLCK(ub)ALAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQSPLDLCPDPNLCKALAK 19 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 257850800.0 101790000.0 8926300.0 147134500.0 True False 84642895.06158613 8878212.250168167 177899643.6769363 1.0 0.10489022432075822 2.101767000614719 26.33488563735776 -6.784827295751509 1.5168046450497017 0.496345648691439 2.120121826247964 0.7841840605917654 0.3793946923737923 0.24314327550943673 1.1051012182904354 0.19693844243949526 0.4629037137213237 1.6412423100838042e-07 6.784827295751509 1.623776177556525 GQSPLDLCPDPNLCK(ub)ALAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQSPLDLCPDPNLCKALAK 19 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 347114000.0 92411500.0 200428500.0 54274000.0 True False 119628508.4529984 189274477.78418866 44396688.89826741 1.0 1.5821853856729635 0.3711213110686798 26.83398599564734 -6.776003287919526 1.551512395624581 1.331370034174749 0.362720920936318 0.7529297976585659 0.24581549416943682 0.2568570290980458 1.220964907392892 0.12482579947895325 0.2955271580584934 1.674930195560141e-07 6.776003287919526 -0.968649113238431 down GQSVGK(ub)LGVLHPDVITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQSVGKLGVLHPDVITK 17 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 1 26322600.0 6957200.0 11369000.0 7996400.0 True False 9120956.573620634 9672789.516014911 7169009.234885086 1.0 1.060501652205019 0.7859931331784965 23.120753706395018 -6.84891911315465 1.2403075079969228 1.032258222714343 0.7752467492818211 0.9387166938800546 0.029152918003387866 0.15864959775126422 0.47020152393136455 0.018397452902627898 0.04254416489593719 1.4160574944698976e-07 6.84891911315465 -0.25701147343252195 GQSVGK(ub)LGVLHPDVITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQSVGKLGVLHPDVITK 17 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 1 42790000.0 15217000.0 14847000.0 12726000.0 True False 14733944.664364666 20775484.52608217 9392678.828183454 1.0 1.4100422527260805 0.6374856864299531 23.812640393691932 -6.7625343097079735 1.6031914232234323 1.2374265686207238 0.6343295947532773 0.7011317025373379 0.17253148659053577 0.27867895266475307 1.412278160965751 0.08489314752310559 0.2034830842546865 1.7276894858810278e-07 6.7625343097079735 -0.6030969738674464 GQSVGK(ub)LGVLHPDVITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQSVGKLGVLHPDVITK 17 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 1 27226700.0 6957200.0 10358000.0 9911500.0 True False 9529464.851260621 9900349.310674481 7570607.833750052 1.0 1.0389197573213984 0.7944420753856458 23.18396376791791 -6.866147563107055 1.15420297200746 1.0215759832373081 0.7811300747175954 0.9606889442037371 0.0212660227198525 0.14060642794119954 0.3524987697434033 0.014329482924412237 0.03371841872321774 1.36098217398548e-07 6.866147563107055 -0.2404459085197127 GQSVGK(ub)LGVLHPDVITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQSVGKLGVLHPDVITK 17 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 1 37684400.0 15217000.0 15782000.0 6685400.0 True False 12653609.727401087 15696979.233518288 8083286.230202921 1.0 1.240513938052543 0.6388126711936404 23.59304566912621 -6.7982502395659825 1.463265962947183 1.1329981390221433 0.6308814523231521 0.8269343531677548 0.10287331622549512 0.2232667656915705 0.9439889481203602 0.0553152509985452 0.12876987933448786 1.5912915639944296e-07 6.7982502395659825 -0.5021166866989912 GQSVGK(ub)LGVLHPDVITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQSVGKLGVLHPDVITK 17 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 1 171997000.0 61661000.0 64160000.0 46176000.0 True False 79821380.02002263 60589439.598827176 37772441.80577067 1.0 0.7590627922447437 0.4732120867403661 26.250271885817327 -6.968861399532101 0.2840667957497598 1.0599691391818207 0.16354648850920978 0.9999720889805195 0.0011375433437831207 0.07667391830838068 0.010346322788476891 0.005159347138199964 0.02610551019750214 1.0743322193457419e-07 6.968861399532101 -0.896422650672611 down GQTCVVHYTGMLEDGK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQTCVVHYTGMLEDGKK 17 1 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 1 22689300.0 8594000.0 9189600.0 4905700.0 True False 11771434.044117443 8783573.086056588 3747074.696062923 1.0 0.7461769783645024 0.3183193043446949 23.48878675028979 -6.9632457501138765 0.3869808521456487 1.02717772642145 0.02201928303498343 0.9998722913885236 0.0031789380008769956 0.0785614070507287 0.016990997086829267 0.005534668131625469 0.03603767285422563 1.088314085057028e-07 6.9632457501138765 -1.0051584433864666 down GQTCVVHYTGMLEDGKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQTCVVHYTGMLEDGKK 17 1 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 12376700.0 3129100.0 3411500.0 5836100.0 False True 4102280.402247506 2902517.4979228433 5232236.355824225 1.0 0.7075375677227349 1.2754458112998937 21.967994676721187 -6.766739076968467 1.5870476835891512 0.8315537366898456 1.278245795816413 0.7178992439257177 0.12315999118698107 0.27173136640952805 1.350216646326335 0.06118890729504375 0.14608847637233308 1.711042996670528e-07 6.766739076968467 0.4466920591265675 GQTCVVHYTGMLEDGKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQTCVVHYTGMLEDGKK 17 1 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 12170800.0 3129100.0 5063100.0 3978600.0 False True 4286012.83074795 4839395.500567289 3038936.621839076 1.0 1.12911362883689 0.7090358199671447 22.031204738244078 -6.824201423847032 1.3537018661497553 1.0693104456837947 0.6990197045574814 0.8937547675703642 0.057265933490602425 0.18807753778880093 0.6760634425284063 0.03323361263416262 0.07652199337268645 1.4989894496238438e-07 6.824201423847032 -0.3702907411263133 GQTCVVHYTGMLEDGKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQTCVVHYTGMLEDGKK 17 1 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 1 26153700.0 13454600.0 7085000.0 5614100.0 True False 13027491.08767568 9914077.447786896 4143598.790610142 1.0 0.7610120307175533 0.3180657551575749 23.635055932009553 -6.96150562636047 0.4136675297050424 1.0209663034601844 0.041574687566811895 0.9998220280622898 0.0037689670492910255 0.07916760079966878 0.019175928119558608 0.005710896596114148 0.036940005843978246 1.0926834711929944e-07 6.96150562636047 -0.9793916158933724 down GQTCVVHYTGMLEDGKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQTCVVHYTGMLEDGKK 17 1 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 1 21855900.0 8567100.0 6517500.0 6771300.0 True False 12996917.03890477 5354401.203540075 5432949.5870337775 1.0 0.4119747158123956 0.41801833240689856 23.63166611052963 -10.179120327534346 6.054038400200972 1.0000062736616373 0.4149965241103582 0.9999199602365959 0.002467296142940216 2.0892542992375795e-07 2.8330742536865487e-08 0.0023889747945035557 0.0007963164059785212 6.620330525072646e-11 10.179120327534346 -0.5850097495512792 GQTCVVHYTGMLEDGKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQTCVVHYTGMLEDGKK 17 1 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 1 21408300.0 8054400.0 8960200.0 4393700.0 True False 11032329.341975745 8564308.736580951 3355998.551091923 1.0 0.776291975258164 0.30419673371452377 23.39523409478947 -6.958981193588371 0.44956191218250985 1.0152924351641004 0.046494646604384716 0.9997305268861405 0.004761038498824117 0.0800670829410934 0.0224913100429739 0.006305932082226748 0.03905261529777036 1.0990534311118347e-07 6.958981193588371 -0.9687977885597157 down GQTCVVHYTGMLEDGKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQTCVVHYTGMLEDGKK 17 1 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 1 31660500.0 13454600.0 8865600.0 9340300.0 True False 11188096.039842982 8817839.253116189 11293313.545332251 1.0 0.7881447586536754 1.009404415649863 23.41546120744383 -11.074758619054254 10.593973635796052 1.627018568219884 0.8987745871474583 0.2181820492101827 0.09032887671731428 0.04261465209550952 0.0003007197515316132 0.0027861506305124043 0.029153519600648426 8.418629191891537e-12 11.074758619054254 -0.7282439810724258 GQTCVVHYTGMLEDGKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQTCVVHYTGMLEDGKK 17 1 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 1 21369500.0 8567100.0 8072300.0 4730100.0 True False 11090279.832787937 7623069.408878016 3869270.334924547 1.0 0.6873649289119593 0.34888843142489656 23.40279243262208 -7.14348308461806 0.27848678806951493 1.0841386747022113 9.480836661734661e-13 0.9999602832311972 0.0016756300737945167 0.0817043589454964 0.012515428992738307 0.008653709715878907 0.03499239574962989 7.186491485774362e-08 7.14348308461806 -1.0841386747012631 down GQTGHFEGSGHGSWGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQTGHFEGSGHGSWGKR 17 1 Q8N5U6;Q8N5U6-2;F5H5P6 Q8N5U6 RNF10 RING finger protein 10 1 4041620.0 365720.0 1344500.0 2331400.0 True False 304112.384143072 1337256.9116376466 2818884.960824346 1.0 4.397245825439729 9.269221208361511 18.21424504180193 -6.965993151086945 0.3405770145123053 0.4750840774427264 13.353433826480952 0.9999321783518427 0.027948799038544643 0.07762553113640064 0.013680488927758205 0.06865400537914752 0.4215126317686019 1.0814510058676332e-07 6.965993151086945 12.878349749038225 GQTHTLEDFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQTHTLEDFQR 11 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 8239070.0 1806000.0 684070.0 5749000.0 False True 1748669.518554419 957222.7183779229 4243164.433696889 1.0 0.5474005855430217 2.426510206001993 20.73782622908485 -6.843118700445704 1.2679971956401765 0.7592538991506997 2.4921637482448538 0.9296574898743502 0.21237668502169474 0.16519059445180742 0.5145952896892333 0.13126760010834937 0.30268765232701317 1.435097142042106e-07 6.843118700445704 1.732909849094154 up GQTLLRPFITSK(ub)PPVQYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQTLLRPFITSKPPVQYR 18 2 J3KTE1;Q8WU67;J3QQR0 J3KTE1 ABHD3 Phospholipase ABHD3 1 46531300.0 4407000.0 11395000.0 30729300.0 True False 5777619.677448703 9694910.417362114 27549726.812259816 1.0 1.6780111808334224 4.768352427175563 22.462043808270394 -6.941889225708758 0.6417463230281842 0.966125469728546 5.650176578320472 0.9984010397961108 0.06558408254203035 0.08691521757365309 0.050763267614805506 0.06479513409701672 0.26384473708374545 1.1431698827833863e-07 6.941889225708758 4.684051108591926 GQTLLRPFITSK(ub)PPVQYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQTLLRPFITSKPPVQYR 18 2 J3KTE1;Q8WU67;J3QQR0 J3KTE1 ABHD3 Phospholipase ABHD3 1 83635500.0 11463000.0 18304500.0 53868000.0 True False 11099113.33952896 25613582.306706447 39758354.79463978 1.0 2.3077142761922165 3.582119902590985 23.403941094682658 -6.971441395378421 0.22106454011069332 0.4201435586433432 5.505720989244684 0.9999915477592497 0.003064770672366411 0.07583772268074568 0.007333546462695907 0.03501413263746749 0.1288778813012251 1.0679688968116148e-07 6.971441395378421 5.08557743060134 GQTLLRPFITSK(ub)PPVQYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQTLLRPFITSKPPVQYR 18 2 J3KTE1;Q8WU67;J3QQR0 J3KTE1 ABHD3 Phospholipase ABHD3 1 383358500.0 20777500.0 103147000.0 259434000.0 True False 31520986.538717166 84739611.95881052 208156756.18603826 1.0 2.6883553233565523 6.603751311221168 24.909809352947512 -6.957050841705677 0.4751778781059723 0.9016196526761734 8.552405919273225 0.999644695275896 0.044243063065197985 0.08077194696312442 0.025155334294796734 0.05467751561108506 0.32305528815729084 1.1039493759051544e-07 6.957050841705677 7.650786266597051 GQTLLRPFITSK(ub)PPVQYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQTLLRPFITSKPPVQYR 18 2 J3KTE1;Q8WU67;J3QQR0 J3KTE1 ABHD3 Phospholipase ABHD3 1 60320400.0 4407000.0 11617400.0 44296000.0 True False 6036386.994696938 11104104.8543956 33834197.10475638 1.0 1.8395283245011846 5.605041084092232 22.525253869793286 -6.942254444148558 0.6382447579871712 0.9588234289704491 6.6915742763649115 0.998444539991311 0.07897750328072736 0.0867530123092098 0.05003770614479422 0.07826175664196292 0.32100917629953035 1.1422089421378328e-07 6.942254444148558 5.732750847394462 GQTLLRPFITSK(ub)PPVQYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQTLLRPFITSKPPVQYR 18 2 J3KTE1;Q8WU67;J3QQR0 J3KTE1 ABHD3 Phospholipase ABHD3 1 83807000.0 11463000.0 19056000.0 53288000.0 True False 9531992.397003265 18953341.545680143 64430274.42412608 1.0 1.9883924321675737 6.759371151448057 23.184346370116934 -6.940593678451125 0.6540165536190645 0.9469464401498463 8.068740137511522 0.9982406392242643 0.10547478144847654 0.08749681638509706 0.053383973985726876 0.10313967762627486 0.4095662859282603 1.1465851733377707e-07 6.940593678451125 7.121793697361676 GQTLLRPFITSK(ub)PPVQYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQTLLRPFITSKPPVQYR 18 2 J3KTE1;Q8WU67;J3QQR0 J3KTE1 ABHD3 Phospholipase ABHD3 1 281027500.0 20777500.0 90518000.0 169732000.0 True False 26896883.33575555 85480593.72828309 138842517.59738973 1.0 3.1780854555237226 5.162029959538788 24.68093567503996 -7.1939141923891885 0.2208489233647754 8.76456020136753e-25 7.957735282917507 0.9999827089832108 0.007068009630626471 0.09309932739304189 0.010930110104760044 0.09099603731254466 0.2698447324220218 6.3986124634763e-08 7.1939141923891885 7.957735282917507 GQTLVVQFTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQTLVVQFTVK 11 0 P27797 P27797 CALR Calreticulin 0 33799700.0 10923000.0 13085000.0 9791700.0 False True 14320158.778482458 11132769.004930513 8778548.81261871 1.0 0.7774193832025569 0.613020354621305 23.77154415315863 -6.974444719849529 0.10813049431060641 1.355909083454725 0.030339920081965996 0.9999996442802994 9.440300295152647e-05 0.07488486944233529 0.0031917136680854087 0.01336148105938186 0.025475610924638042 1.0606089317753692e-07 6.974444719849529 -1.3255691633727589 GQTLVVQFTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQTLVVQFTVK 11 0 P27797 P27797 CALR Calreticulin 0 122039000.0 57174000.0 27708000.0 37157000.0 False True 55359042.66546538 38771948.89531117 27424467.01389381 1.0 0.7003724600082051 0.4953927252611615 25.722315658600053 -8.048708340312816 0.12983673521436614 1.4136290815481827 8.505928733516451e-13 0.999969620046325 0.0011420827998965377 0.1001947464420937 0.02260909288981216 0.10553492469216272 0.12139180853614302 8.939056035008315e-09 8.048708340312816 -1.413629081547332 down GQTLVVQFTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQTLVVQFTVK 11 0 P27797 P27797 CALR Calreticulin 0 1382550000.0 384980000.0 408720000.0 588850000.0 False True 584042805.8079815 335780722.65606475 472463539.39787614 1.0 0.5749248502282912 0.8089536155560663 29.12149887043661 -10.213713507054191 5.2333833286114215 1.000023642729124 0.6919392328920854 0.6979148377039147 0.09554184336475963 2.6357787106620836e-05 3.960045780890304e-06 0.09251508393655256 0.030835997351425525 6.113451806720432e-11 10.213713507054191 -0.30808440983703866 GQTLVVQFTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQTLVVQFTVK 11 0 P27797 P27797 CALR Calreticulin 0 58053000.0 10923000.0 11573000.0 35557000.0 False True 14961528.282975871 11061666.593206763 27159168.919401802 1.0 0.7393406865923847 1.8152670239112632 23.83475421468152 -6.842696208240146 1.269753801673779 0.8613432009741713 1.8525995336887553 0.9289983671115896 0.12211505640731443 0.16567496457605718 0.5176915766578106 0.07537432544031836 0.17379996154439417 1.4364939186482605e-07 6.842696208240146 0.991256332714584 GQTLVVQFTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQTLVVQFTVK 11 0 P27797 P27797 CALR Calreticulin 0 119412000.0 57174000.0 21621000.0 40617000.0 False True 47542714.237657286 21504523.38156752 49109826.908210665 1.0 0.4523200605264218 1.0329622045287459 25.50272093403433 -10.131418772448308 14.79794137551539 0.9999989694737217 0.7426444370388656 0.20756856991575345 0.23704616267632303 0.0 0.0 0.22951896010242082 0.07650632003414025 7.388924476001864e-11 10.131418772448308 -0.25735453243485606 GQTLVVQFTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQTLVVQFTVK 11 0 P27797 P27797 CALR Calreticulin 0 1181510000.0 384980000.0 492080000.0 304450000.0 False True 498364199.09032226 464695315.4269153 249043223.92080036 1.0 0.9324412072037604 0.4997213370771531 28.89262519252906 -6.934468072305466 0.7091544069761561 1.0056171121386757 0.39985354293035885 0.9973458868984337 0.011418090007066341 0.0903831859431885 0.06679426878802708 0.01069428268356896 0.038237528466778296 1.16287203783323e-07 6.934468072305466 -0.6057635692083168 down GQTPGGAQFVGLELYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQTPGGAQFVGLELYK 16 0 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A590UJR3;A0A590UJ21;A0A590UJ56;A0A590UJA0;A0A590UJM8;A0A590UJ97 A0A590UJC4 CUL1 Cullin-1 0 7086200.0 2349100.0 2346900.0 2390200.0 False True 3079692.8487167615 1996751.668144548 2142885.032417381 1.0 0.6483606535556133 0.6958112830343691 21.55435504111129 -10.139576005977583 4.775943497396995 1.0000254931378827 0.6720859682929579 0.9845382779221029 0.01937163837423135 5.258772061682318e-06 9.474292270408926e-07 0.018757964878830094 0.006252169399863096 7.251435594437223e-11 10.139576005977583 -0.32793952484492483 GQTQEEEVRPK(ub)GR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQTQEEEVRPKGR 13 2 O15234;J3KSY7 O15234 CASC3 Protein CASC3 1 8141850.0 1526400.0 6114100.0 501350.0 True False 1477945.2675091175 8555492.014610292 370031.39482239285 1.0 5.788774593141362 0.25036880793700306 20.49516141272214 -6.67800948074281 1.908941676878023 4.035358973882559 0.2718033886276434 0.3149816845899617 2.0304964299199506 0.44300229298246324 3.119384178029134 0.8540426541651186 2.2582554719618155 2.0988940638103872e-07 6.67800948074281 -3.763555585254916 GQTQEEEVRPK(ub)GR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQTQEEEVRPKGR 13 2 O15234;J3KSY7 O15234 CASC3 Protein CASC3 1 4727380.0 3524900.0 747390.0 455090.0 True False 5347531.004708173 614012.4151152772 365141.2620269676 1.0 0.1148216652834134 0.06828221504568803 22.35044151140997 -13.307374317825284 0.42664647196655026 9.999999999995863 0.0670920758490199 0.999860500320427 0.005062991175270924 16.839880944871595 0.2180510986498119 138.59468101857564 0.011108179417177285 4.927489212510004e-14 13.307374317825284 -9.932907924146843 GQTQEEEVRPK(ub)GR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQTQEEEVRPKGR 13 2 O15234;J3KSY7 O15234 CASC3 Protein CASC3 1 9394790.0 3524900.0 4351500.0 1518390.0 True False 4563052.536166751 4109335.1997240805 1242058.5999970553 1.0 0.9005671460395192 0.27219905757220625 22.121567833502418 -6.934746735816301 0.7067414277977145 1.008082977440067 0.12608125862441127 0.9973917138212983 0.016456184880962503 0.0902468974009809 0.06614714585652735 0.015440910637142471 0.05544775417619819 1.1621261244549169e-07 6.934746735816301 -0.8820017188156557 down GQVAK(ub)LEAALGEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQVAKLEAALGEAK 14 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 44811800.0 17179500.0 14313300.0 13319000.0 True False 22522490.866514646 12177811.432806425 11940877.644869497 1.0 0.540695587578717 0.5301757126083518 24.42486305477562 GQVAK(ub)LEAALGEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQVAKLEAALGEAK 14 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 70304100.0 30724000.0 23406000.0 16174100.0 True False 29748683.43746733 32752137.860677544 11937617.997400759 1.0 1.100960919145332 0.4012822289259963 24.826322485900477 -6.870279002589887 1.132565786503124 1.057202157775685 0.360078378306107 0.964963554749486 0.05780090288677982 0.13659039459507596 0.32728128135459483 0.03959944615856647 0.09380274236027253 1.3480965504456406e-07 6.870279002589887 -0.6971237794695779 down GQVAK(ub)LEAALGEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQVAKLEAALGEAK 14 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 114609000.0 49053000.0 47671000.0 17885000.0 True False 74416987.25465968 39163737.594776966 14350021.910726016 1.0 0.5262741618490433 0.19283261040411814 26.14912864886034 -8.168375078439047 0.3008372195977773 1.1395351768242779 1.2772857188727602e-17 0.9990175963456857 0.010380262533546973 0.0906571241445973 0.06664763583269753 0.07575815908485152 0.09400298101313265 6.786172916177794e-09 8.168375078439047 -1.1395351768242779 down GQVAK(ub)LEAALGEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQVAKLEAALGEAK 14 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 55834700.0 17179500.0 26937400.0 11717800.0 True False 23531225.408530995 25747216.59793037 8950296.975666283 1.0 1.0941723667563863 0.3803583035000569 24.488073116298512 -6.87367683004102 1.1144123429928225 1.054654526218032 0.3355162351882831 0.9682194114671131 0.05644797584988797 0.1333807989626722 0.30736281600729487 0.03921484443047002 0.09348658753195933 1.3375904826072438e-07 6.87367683004102 -0.7191382910297489 down GQVAK(ub)LEAALGEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQVAKLEAALGEAK 14 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 66154500.0 30724000.0 24756400.0 10674100.0 True False 25548367.303980503 24623032.35943932 12906004.958537856 1.0 0.9637810536567237 0.5051596763495358 24.606727761334753 -6.922635164322486 0.8049584689479387 1.009191112803915 0.4265309553245298 0.9948816826633574 0.016112709450744663 0.09664647541206417 0.09776689400093973 0.014079986944260221 0.043298817137859 1.1949915537334063e-07 6.922635164322486 -0.5826601574793853 GQVAK(ub)LEAALGEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQVAKLEAALGEAK 14 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 109942200.0 49053000.0 44570000.0 16319200.0 True False 63500075.47918736 42089640.319821194 13349273.049132269 1.0 0.6628281935446895 0.21022452254419124 25.92025497095279 -7.3531474074013286 0.4102129600883803 1.0303278159087859 3.140597990710708e-21 0.9992661480036595 0.008765423974082554 0.10774143257046775 0.03796553654571333 0.013792824554722359 0.05668949894343945 4.434581006850614e-08 7.3531474074013286 -1.0303278159087859 down GQVCVMIHSGSR ddPTM_RPMI8226_Bortezomib_1h_R1 2 GQVCVMIHSGSR 12 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 118822700.0 46931700.0 33380600.0 38510400.0 False True 61527913.18722936 28400344.59655967 34525713.22584145 1.0 0.46158472025757574 0.5611390251572445 25.87473772638332 -9.887315012852055 5.549919763407411 1.0000003263434842 0.5113618727056503 0.9698079636784673 0.04064287479029853 1.6410489653920108e-07 3.285976366726613e-08 0.03935232068535878 0.01311743143276363 1.296238711072052e-10 9.887315012852055 -0.488638453637834 GQVCVMIHSGSR ddPTM_RPMI8226_Bortezomib_2h_R1 2 GQVCVMIHSGSR 12 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 47576800.0 21772200.0 9606200.0 16198400.0 False True 21081053.428499755 13442005.755671201 11955553.098416386 1.0 0.637634442759809 0.5671231344755057 24.329443625024425 -13.999999999999998 0.23014388255881374 3.289030847901437 0.5328868338171993 0.9995099901176194 0.004197853680057444 13.2957876017918 0.15189745336383043 13.908403670550996 0.03656901112952447 1.0000000000000041e-14 13.999999999999998 -2.7561440140842377 GQVCVMIHSGSR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GQVCVMIHSGSR 12 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 249294400.0 70688000.0 79185400.0 99421000.0 False True 107238863.98502393 65054146.691645905 79770395.77222776 1.0 0.6066284579509422 0.7438571503645154 26.676252600691157 -10.814057207414292 8.30942366797683 1.0092572361191363 0.6752428041577287 0.8818992810689514 0.056023379080432534 0.009581349523745609 0.0002144047635734762 0.05409512405000781 0.01808146784806503 1.534414848783636e-11 10.814057207414292 -0.33401443196140757 GQVCVMIHSGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GQVCVMIHSGSR 12 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 102971800.0 46931700.0 24083600.0 31956500.0 False True 64283617.77150416 23019506.918184947 24409032.864776645 1.0 0.3580928970116101 0.3797084500056989 25.93794778790621 -10.16318108832979 5.0516688244564785 1.0000373908179458 0.36890067350790184 0.9991209435189922 0.008824512560311292 3.7163672187487864e-06 6.156189660657891e-07 0.008544802120984003 0.002848099181604169 6.867820119216776e-11 10.16318108832979 -0.631136717310044 GQVCVMIHSGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQVCVMIHSGSR 12 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 35856300.0 17770200.0 5245900.0 12840200.0 False True 14776708.65333924 5217639.295470376 15525026.453623023 1.0 0.35309888134603595 1.050641710399743 23.816821625286018 -11.973445641925364 14.67305516145238 0.9252967379795431 0.7316832662861141 0.0 0.3250920357799885 0.0 0.0 0.0 0.09452943209225982 1.0630516308416112e-12 11.973445641925364 -0.19361347169342902 GQVCVMIHSGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GQVCVMIHSGSR 12 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 298962000.0 70688000.0 138459000.0 89815000.0 False True 91507009.46879484 130753634.9347571 73469591.57972294 1.0 1.4288920126861528 0.8028848500920259 26.447378922783606 -6.7223091802250545 1.750893863955481 1.2602956420093823 0.803728090189066 0.5233347486384875 0.18043166478643546 0.35090527838350816 2.1035475696463113 0.08178254970246217 0.20475799553026952 1.8953561106657986e-07 6.7223091802250545 -0.4565675518203163 GQVEVFALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQVEVFALR 9 0 Q9BQ67;M0QX71 Q9BQ67 GRWD1 Glutamate-rich WD repeat-containing protein 1 0 8077200.0 2738800.0 2454700.0 2883700.0 False True 3590593.3225769247 2088468.3283456566 2585322.386403646 1.0 0.5816499226503291 0.7200265120941605 21.77579082919773 -10.355830656250356 4.981509541396175 1.00021581964306 0.6508382173721692 0.894617065691538 0.05649200608092619 0.00013548972500346712 1.7520503254047178e-05 0.05473161850060719 0.018232716562068773 4.4072668185298724e-11 10.355830656250356 -0.34937760227089076 GQVFALSTHPYGCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQVFALSTHPYGCR 14 0 H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;H0YDK8;H0YDQ6 H0YEH2 PUM1 Pumilio homolog 1 0 9928100.0 5996500.0 0.0 3931600.0 False True 7861469.570188612 0.0 3524795.7465702277 1.0 0.0 0.44836346628327167 22.90636759471499 -10.482710117148535 5.179460424655497 1.0016235943250293 0.22418173314162673 0.7996823529759607 0.18304361861664145 0.003437652531370378 0.000343329415911327 0.17753493770636347 0.059077073877643195 3.290712060132084e-11 10.482710117148535 -0.7774418611834026 GQVFVLSTHPYGCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQVFVLSTHPYGCR 14 0 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72 A0A0C4DG68 PUM2 Pumilio homolog 2 0 31920400.0 9793400.0 10407000.0 11720000.0 False True 12839242.239420513 8854316.166168269 10507326.826178443 1.0 0.6896291853566507 0.8183759314017492 23.614056722614905 -10.079016247764113 5.006904229441324 1.0000060207853807 0.7540025586457174 0.8295766394891051 0.05256063897960887 3.532611295601727e-06 6.497939403076084e-07 0.050892865587595246 0.01696387328561059 8.3364999563976e-11 10.079016247764113 -0.2460034621396633 GQVFVLSTHPYGCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQVFVLSTHPYGCR 14 0 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72 A0A0C4DG68 PUM2 Pumilio homolog 2 0 15440900.0 3819800.0 5030700.0 6590400.0 False True 5794915.864786032 4132932.2799614957 5287804.551325065 1.0 0.7131997040847629 0.9124903061073707 22.46635628450983 -10.077945910006145 5.270412821831785 1.0000025858048176 0.8128450057351317 0.5404186552279606 0.08136004758209783 2.4720866651150184e-06 4.325472305251714e-07 0.07877761543557779 0.026258842444219183 8.357070964057136e-11 10.077945910006145 -0.18715758006968586 GQVFVLSTHPYGCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQVFVLSTHPYGCR 14 0 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72 A0A0C4DG68 PUM2 Pumilio homolog 2 0 21522200.0 9793400.0 4308400.0 7420400.0 False True 13414284.636683702 4118040.6420264454 5667854.3479351215 1.0 0.3069892099027737 0.4225237872495552 23.677266784137796 -9.942124427246728 5.791697342588788 1.0000004742912196 0.3647564985837402 0.9757918308104551 0.04716679369275292 2.888524264173922e-07 5.2757383601887094e-08 0.04566908632060752 0.015223017205289102 1.1425509421075927e-10 9.942124427246728 -0.6352439757074795 GQVLNIQMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQVLNIQMR 9 0 P05455;E7ERC4;E9PGX9 P05455 SSB Lupus La protein 0 223787000.0 48326000.0 83418000.0 92043000.0 False True 63355853.98964971 70972359.56081724 82519273.29880048 1.0 1.1202178660935076 1.3024727488052084 25.916974592680194 -6.965079842646404 0.35667899320064833 0.9836870878605641 1.4452171088973162 0.9999147802236431 0.0011478866517399262 0.07793386704347376 0.014764437388582683 0.0024624368558568864 0.015598368003054629 1.0837276583499123e-07 6.965079842646404 0.4615300210367521 GQVLNIQMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 GQVLNIQMR 9 0 P05455;E7ERC4;E9PGX9 P05455 SSB Lupus La protein 0 143181200.0 52502100.0 36645800.0 54033300.0 False True 50835449.573696524 51278659.04532246 39880357.76574613 1.0 1.0087185118916557 0.7844989687350219 25.59933156057971 -6.897853635211139 0.9747535378290452 1.0098791451439924 0.7619641807840173 0.9854673779686061 0.012501681347646698 0.1130019137644226 0.18647125578719442 0.00965683451544397 0.02486506402115618 1.2651626574354924e-07 6.897853635211139 -0.24791496435997507 GQVLNIQMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQVLNIQMR 9 0 P05455;E7ERC4;E9PGX9 P05455 SSB Lupus La protein 0 84842000.0 38014000.0 0.0 46828000.0 False True 57670017.19565838 0.0 37572425.27455851 1.0 0.0 0.6515070933148102 25.78131811677975 -10.307546715377383 7.540804495704784 1.0000040472853864 0.32575354665740514 0.5881437251072228 0.2659766570708517 1.8097758292311355e-05 1.6620840185709464e-06 0.25753233222795935 0.08584359694294415 4.925533584405759e-11 10.307546715377383 -0.6742505006279813 GQVLNIQMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GQVLNIQMR 9 0 P05455;E7ERC4;E9PGX9 P05455 SSB Lupus La protein 0 155946000.0 51613100.0 42435900.0 61897000.0 False True 70695857.86158222 40560941.62124458 47278203.40873001 1.0 0.5737385873534515 0.6687549290553568 26.075122352830146 -10.243827401333684 5.657398872086774 1.0000199703810637 0.6212467582044049 0.9549271115917566 0.03879025906596437 9.771244754709474e-06 1.3060632958917065e-06 0.037560484418718905 0.012519502279791395 5.703909137758447e-11 10.243827401333684 -0.3787732121766588 GQVLNIQMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GQVLNIQMR 9 0 P05455;E7ERC4;E9PGX9 P05455 SSB Lupus La protein 0 108273500.0 52502100.0 30664100.0 25107300.0 False True 43657822.38739466 30498906.406952694 30357120.346961092 1.0 0.6985897312129488 0.6953420644206505 25.379736836013986 GQVLNIQMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQVLNIQMR 9 0 P05455;E7ERC4;E9PGX9 P05455 SSB Lupus La protein 0 103069000.0 38014000.0 65055000.0 0.0 False True 49209872.3679658 61434632.06205903 0.0 1.0 1.248420877881634 0.0 25.5524444388722 -6.8987615184535755 1.3009852621296125 1.1294026534575168 2.674815222566611e-23 0.9459244364980192 0.1254735243619542 0.1353560086546021 0.4598733156217266 0.0787331423651976 0.15713825769231463 1.2625206247204145e-07 6.8987615184535755 -1.1294026534575168 down GQVPPLVTTNFLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQVPPLVTTNFLVK 14 0 G5EA31;P53992 G5EA31 SEC24C Protein transport protein Sec24C 0 5565500.0 1618800.0 2080200.0 1866500.0 False True 2122262.4764814987 1769842.2685560917 1673372.4847322549 1.0 0.8339412717178675 0.7884851677284239 21.01717166577502 -13.999996576875548 0.18180201105798666 1.8664272425572472 0.7530409124125188 0.99949607209335 0.0020407515066959425 12.228565412463256 0.13518102261647363 3.7442585036526768 0.033426442012402684 1.0000078820663987e-14 13.999996576875548 -1.1133863301447284 GQVPPLVTTNFLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQVPPLVTTNFLVK 14 0 G5EA31;P53992 G5EA31 SEC24C Protein transport protein Sec24C 0 5298000.0 1618800.0 1669200.0 2010000.0 False True 2217314.1064250986 1595449.2246937465 1535279.39724942 1.0 0.7195413676711938 0.692405010548866 21.08038172729791 -13.999999999999998 0.3302675774311389 4.057905123529747 0.6876142218783258 0.9997153957805265 0.0023457559943868608 18.846139583158696 0.18378762831270648 40.036183724984475 0.008687367155317628 1.0000000000000041e-14 13.999999999999998 -3.3702909016514213 GQVTFLSIHPSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQVTFLSIHPSGK 13 0 Q9NWT1 Q9NWT1 PAK1IP1 p21-activated protein kinase-interacting protein 1 0 25659300.0 8796400.0 4416500.0 12446400.0 False True 11532165.584458783 3757575.4153821603 11158565.922299247 1.0 0.32583432728767114 0.9676036855850375 23.459160121224848 -10.92773823116256 10.271597822160253 1.063955286045499 0.6467190064363547 0.28776814691961095 0.2620012433969902 0.13800572911848913 0.0009708835327391726 0.09123603390409067 0.08456053769684822 1.1810322824895419e-11 10.92773823116256 -0.41723627960914433 GQVTFLSIHPSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQVTFLSIHPSGK 13 0 Q9NWT1 Q9NWT1 PAK1IP1 p21-activated protein kinase-interacting protein 1 0 21193340.0 7302000.0 2608840.0 11282500.0 False True 7070202.006912723 3650563.4169208724 8327274.782255204 1.0 0.5163308507100108 1.1777987070402527 22.753320005038876 -6.710681796137867 1.7925208500537317 0.7028535384075384 1.17628985455781 0.4683563467310926 0.20379517134793199 0.37375878460581424 2.341385123441907 0.0904551436835628 0.229630604907921 1.94678595265752e-07 6.710681796137867 0.4734363161502716 GQVTFLSIHPSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQVTFLSIHPSGK 13 0 Q9NWT1 Q9NWT1 PAK1IP1 p21-activated protein kinase-interacting protein 1 0 23270900.0 8796400.0 5046600.0 9427900.0 False True 12048666.793771783 4823624.525125494 7201224.193695416 1.0 0.40034508445523037 0.5976780930997183 23.52237018274774 -10.242408915419645 4.81775473216966 1.0001121855853567 0.49901158877656326 0.8957680315244432 0.08056086343442008 9.709715370301777e-05 1.526843128554082e-05 0.07802006355566167 0.026000906869342387 5.7225696151814716e-11 10.242408915419645 -0.5011005968087935 GQVTFLSIHPSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQVTFLSIHPSGK 13 0 Q9NWT1 Q9NWT1 PAK1IP1 p21-activated protein kinase-interacting protein 1 0 13471000.0 7302000.0 3245600.0 2923400.0 False True 6071936.533448304 3228115.308598839 3534669.4237256097 1.0 0.5316451005072619 0.58213214256346 22.533725280473153 -10.741322527760753 10.621223516204712 1.0007925773384891 0.5568886218234507 0.9903575507022601 0.020611248610020047 0.0003873786289518043 9.434475818191971e-06 0.019984942247517234 0.0066522518842623765 1.8141678749256826e-11 10.741322527760753 -0.4439039555150385 GQVWINGFNLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQVWINGFNLGR 12 0 E7EQ29;P16278-2;P16278-3;P16278;Q6UWU2-2;Q6UWU2 E7EQ29 GLB1;GLB1L Beta-galactosidase;Beta-galactosidase-1-like protein 0 18631700.0 4273700.0 5882400.0 8475600.0 False True 5602862.086569677 5004768.84941561 7598626.21569607 1.0 0.8932521936265886 1.3562044002315055 22.417732550653522 -6.846023567811543 1.2541284159586013 0.9431751380118383 1.3733396626643541 0.934320924238928 0.050726428282590545 0.16188123561442672 0.49196773880736966 0.03168026383006626 0.07314757704168905 1.4255302324086308e-07 6.846023567811543 0.43016452465251587 GQVWINGFNLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQVWINGFNLGR 12 0 E7EQ29;P16278-2;P16278-3;P16278;Q6UWU2-2;Q6UWU2 E7EQ29 GLB1;GLB1L Beta-galactosidase;Beta-galactosidase-1-like protein 0 17754100.0 5529600.0 2531000.0 9693500.0 False True 5354065.874750012 3541641.498990637 7154481.551233403 1.0 0.6614863510912631 1.336270736782344 22.352203458880098 -6.770295775625511 1.5731373670173272 0.8059103458163168 1.3401250825766113 0.7317484978271935 0.14267940190328626 0.2659553094836902 1.2989436449107683 0.07148536554901816 0.17013148574355458 1.6970874598475262e-07 6.770295775625511 0.5342147367602945 GQVWINGFNLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQVWINGFNLGR 12 0 E7EQ29;P16278-2;P16278-3;P16278;Q6UWU2-2;Q6UWU2 E7EQ29 GLB1;GLB1L Beta-galactosidase;Beta-galactosidase-1-like protein 0 16406500.0 4273700.0 5591800.0 6541000.0 False True 5853802.382399899 5344735.78639019 4996150.516123608 1.0 0.9130365935241898 0.8534880731787401 22.480942612176413 -6.975147691311824 0.054360672201601075 1.3587188223350637 0.406326872939291 0.9999999701698076 8.639063603013835e-06 0.07466448915214109 0.001558923592617367 0.011437269517828738 0.015823003823401554 1.0588935640863594e-07 6.975147691311824 -0.9523919493957727 GQVWINGFNLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQVWINGFNLGR 12 0 E7EQ29;P16278-2;P16278-3;P16278;Q6UWU2-2;Q6UWU2 E7EQ29 GLB1;GLB1L Beta-galactosidase;Beta-galactosidase-1-like protein 0 12469300.0 5529600.0 2316000.0 4623700.0 False True 4598107.402815082 2303523.248309992 5590494.292426666 1.0 0.5009720405616699 1.2158250781623803 22.132608734314374 -6.719051467594003 1.7631583751160902 0.6960842643195757 1.2146197537916406 0.5078677750588987 0.21001740108677547 0.35715092306555685 2.169434428520224 0.09460638838437124 0.2377242230269525 1.9096269381039415e-07 6.719051467594003 0.5185354894720648 GQVYILGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQVYILGR 8 0 P00966 P00966 ASS1 Argininosuccinate synthase 0 68039630.0 15976630.0 21122000.0 30941000.0 False True 20945516.647905022 17970679.932911158 27739522.127029605 1.0 0.8579726265529283 1.3243656193032662 24.320138134769646 -6.82500662463974 1.3501719140074941 0.9238115878465382 1.3356745350721142 0.895491494723491 0.06310196707720375 0.18705702567707122 0.6686460803351391 0.03671378329730014 0.08452374179306467 1.4962128329939722e-07 6.82500662463974 0.41186294722557604 GQVYILGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQVYILGR 8 0 P00966 P00966 ASS1 Argininosuccinate synthase 0 45375000.0 10091000.0 4862000.0 30422000.0 False True 9770666.728534136 6803421.954995046 22453565.55956285 1.0 0.6963109216617138 2.298058687642035 23.220025581172962 -6.857629866898678 1.1975630293461148 0.8361438417094509 2.372216000831269 0.9506983188176324 0.15423874752045902 0.14927037477136326 0.40812943115020484 0.1005403242479361 0.23411390062160042 1.3879382132811677e-07 6.857629866898678 1.5360721591218183 up GQVYILGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQVYILGR 8 0 P00966 P00966 ASS1 Argininosuccinate synthase 0 85788630.0 15976630.0 18383000.0 51429000.0 False True 21883621.86319154 17570778.275548264 39282529.413502686 1.0 0.8029191139105945 1.7950652620065726 24.383348196292538 -6.8550847391113665 1.2102939113983602 0.8941774836087552 1.8387955459839187 0.9473829271532769 0.09837472773576796 0.15195274013936766 0.42577533737670736 0.06350942727129778 0.14752565804228282 1.3960959296164147e-07 6.8550847391113665 0.9446180623751635 GQVYILGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQVYILGR 8 0 P00966 P00966 ASS1 Argininosuccinate synthase 0 27349200.0 10091000.0 6930200.0 10328000.0 False True 8391113.607097618 6892865.63706301 12487537.048723426 1.0 0.8214482558349209 1.4881859111239837 23.000430856607238 -6.83543902851984 1.3034153878671428 0.9048907672558961 1.5082070352824342 0.9163225198509585 0.08151897272438906 0.17419435576466955 0.5768201916516613 0.04907543237026552 0.11295889458503598 1.4606998056454163e-07 6.83543902851984 0.603316268026538 GQWINLPVLQLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQWINLPVLQLTK 13 0 Q9NRG9-2;Q9NRG9 Q9NRG9-2 AAAS Aladin 0 7385010.0 727010.0 1998900.0 4659100.0 False True 995805.2437065181 1910581.9885216476 3558716.5371764977 1.0 1.9186301745210843 3.5737073686522143 19.925504086797464 -6.96203495968553 0.4057432411405482 0.9145858306711387 4.638748981776341 0.9998383723372758 0.01353905672594082 0.07898213167691506 0.018503695788239457 0.021294794681081884 0.1383830052556489 1.0913524816018321e-07 6.96203495968553 3.724163151105202 GQWINLPVLQLTK(ub)DPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQWINLPVLQLTKDPLK 17 1 Q9NRG9-2;Q9NRG9 Q9NRG9-2 AAAS Aladin 1 26728800.0 4531400.0 4509400.0 17688000.0 True False 5865986.627247873 4258447.925918824 14468965.494206322 1.0 0.7259559553269468 2.466586852925487 22.483942351495557 -6.866636588032851 1.151668189476059 0.847740900413948 2.5622472282485074 0.961213390501388 0.15050050457548078 0.14012448035746491 0.34945754953233354 0.10160782030853362 0.23926506143890186 1.3594505412782013e-07 6.866636588032851 1.7145063278345594 up GQYFGELALVTNKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQYFGELALVTNKPR 15 1 P13861-2;P13861;H7C330;P31323 P13861-2 PRKAR2A;PRKAR2B cAMP-dependent protein kinase type II-alpha regulatory subunit;cAMP-dependent protein kinase type II-beta regulatory subunit 0 5715000.0 0.0 5715000.0 0.0 False True 0.0 5462492.403022263 0.0 0.0 GQYIK(ub)AVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQYIKAVK 8 1 O94986;O94986-3;O94986-1;O94986-2 O94986 CEP152 Centrosomal protein of 152 kDa 1 13502200.0 4344800.0 6179000.0 2978400.0 True False 5696074.8751030555 5257117.285553351 2670223.7388301888 1.0 0.9229368294527971 0.4687831177398064 22.4415366800298 -6.936215696370028 0.6938733902504473 1.0055815741446856 0.3588414684798334 0.9976250696201013 0.011421866572766086 0.08953619126648643 0.06279351893995826 0.010822113280871922 0.03978318184549855 1.1582019815612419e-07 6.936215696370028 -0.6467401056648523 down GQYIK(ub)AVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQYIKAVK 8 1 O94986;O94986-3;O94986-1;O94986-2 O94986 CEP152 Centrosomal protein of 152 kDa 1 17779900.0 5240200.0 8516600.0 4023100.0 True False 5073852.719340463 11917322.793482292 2969329.4195870566 1.0 2.348771920015722 0.5852218390708495 22.274650211674196 -6.702309417303134 1.8224947196989738 1.8356208045866684 0.5902088585104159 0.4286156047790658 0.569095139583331 0.3907340609861833 2.524683212040559 0.24895834992570745 0.6384693257033811 1.9846804087785284e-07 6.702309417303134 -1.2454119460762525 GQYIK(ub)AVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQYIKAVK 8 1 O94986;O94986-3;O94986-1;O94986-2 O94986 CEP152 Centrosomal protein of 152 kDa 1 28093300.0 8250400.0 11971000.0 7871900.0 True False 12516459.985033419 9834681.520150093 6316015.514623667 1.0 0.7857398603047453 0.504616762421328 23.577323248511217 -6.96738614132659 0.31441682678992194 1.0411113091595354 0.2402516909681368 0.9999542213871594 0.0013724855869737098 0.0771603092517643 0.012051660257300267 0.004361990131165672 0.02485387235092396 1.0779878319492071e-07 6.96738614132659 -0.8008596181913986 GQYIK(ub)AVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQYIKAVK 8 1 O94986;O94986-3;O94986-1;O94986-2 O94986 CEP152 Centrosomal protein of 152 kDa 1 11426500.0 4344800.0 4923700.0 2158000.0 True False 5951189.973805151 4706154.653501444 1648324.8454050971 1.0 0.7907922069730804 0.2769739922033054 22.50474674155269 -6.955840865627572 0.49054983848399764 1.0111886906678447 0.03476894964498163 0.9995834990874612 0.006199658548856282 0.08122168201256649 0.026886096725191332 0.007406675695934667 0.04237821619798571 1.1070293478434807e-07 6.955840865627572 -0.976419741022863 down GQYIK(ub)AVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQYIKAVK 8 1 O94986;O94986-3;O94986-1;O94986-2 O94986 CEP152 Centrosomal protein of 152 kDa 1 17439200.0 5240200.0 9872900.0 2326100.0 True False 4357458.480221284 9819712.728082793 2812476.755328777 1.0 2.2535413183292388 0.645439714020167 22.055055487108472 -6.698700581938107 1.83526763287486 1.7794104594889173 0.650315132751404 0.4113766684571354 0.5292672816456983 0.39831014615802224 2.6072756107142245 0.2301349187714495 0.5928493413818892 2.0012411209303488e-07 6.698700581938107 -1.1290953267375134 GQYIK(ub)AVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQYIKAVK 8 1 O94986;O94986-3;O94986-1;O94986-2 O94986 CEP152 Centrosomal protein of 152 kDa 1 22183200.0 8250400.0 12106000.0 1826800.0 True False 10680305.439697623 11432290.457970725 1494341.1445508883 1.0 1.0704085686049811 0.13991558134625742 23.348449570603666 -6.888656295335393 1.0303243918805134 1.051619091690019 0.061967643140611636 0.9800232745103137 0.05978936277424847 0.12023910169185956 0.2282830146574191 0.04429248092639934 0.10989838710384713 1.2922415609442769e-07 6.888656295335393 -0.9896514485494073 down GQYISPFHDIPIYADKDVFHMVVEVPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GQYISPFHDIPIYADKDVFHMVVEVPR 27 1 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 117080000.0 29287000.0 40512000.0 47281000.0 False True 44430520.1664978 33282317.078299288 37935889.62600155 1.0 0.7490868203563222 0.8538250167641875 25.405047695886573 -10.210170997214098 4.78151801536643 1.0000332104610083 0.8014559185596183 0.8273236032681146 0.04275918963197155 1.5140688234531664e-05 2.500927935474425e-06 0.04140832705158761 0.013800469111517883 6.163522742245888e-11 10.210170997214098 -0.19857729190139006 GQYISPFHDIPIYADKDVFHMVVEVPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQYISPFHDIPIYADKDVFHMVVEVPR 27 1 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 67774000.0 29287000.0 17497000.0 20990000.0 False True 37912598.83307767 16523276.568900887 17170035.375587456 1.0 0.4358254795892493 0.45288468488230055 25.176174017979022 -9.870690609598475 6.883048805848972 1.0000000093692611 0.44435508226800036 0.9992935563150525 0.006964391397590451 1.0027152647993615e-09 1.60583444569216e-10 0.006743243075303081 0.002247747658273694 1.346819483512579e-10 9.870690609598475 -0.5556449271012608 GQYK(ub)DNIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQYKDNIR 8 1 Q8WTS6;B5MCZ8;D6RJA0 Q8WTS6 SETD7 Histone-lysine N-methyltransferase SETD7 1 5161420.0 1796800.0 2621800.0 742820.0 True False 1739761.5675185954 3668698.4125063764 548253.1578776706 1.0 2.108736323988927 0.31513120424865954 20.73045816911723 -6.7394880874597884 1.688551501050586 1.660085832713661 0.3141944469503939 0.6026445586876299 0.46584992472180026 0.31874614814401075 1.7842570867976306 0.21827083657934038 0.5359222464388016 1.8218470450105556e-07 6.7394880874597884 -1.345891385763267 GQYK(ub)DNIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQYKDNIR 8 1 Q8WTS6;B5MCZ8;D6RJA0 Q8WTS6 SETD7 Histone-lysine N-methyltransferase SETD7 1 3682040.0 1458400.0 1620700.0 602940.0 True False 1997609.8917780838 1549092.1150617995 460537.9899390866 1.0 0.7754727894758991 0.23054450813174496 20.92984343966762 -7.00799204414757 0.5045795588807191 1.0101888010689444 4.361652488078097e-12 0.999575483145817 0.00665665724203948 0.075027080321117 0.027494020239780564 0.007913024090311931 0.04126929079890342 9.817659278519956e-08 7.00799204414757 -1.0101888010645828 down GQYK(ub)DNIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQYKDNIR 8 1 Q8WTS6;B5MCZ8;D6RJA0 Q8WTS6 SETD7 Histone-lysine N-methyltransferase SETD7 1 4471100.0 1796800.0 2152300.0 522000.0 True False 1494118.8117364987 2140705.1327018966 631147.7865446969 1.0 1.4327542869324565 0.42242141761883223 20.510863444551507 -6.790296534933627 1.4950622906441229 1.2417660357216689 0.4115726838671267 0.8023371924217254 0.1840066534370529 0.23489318493347014 1.037207095768263 0.09687263483691663 0.22676203899434297 1.6207031083906597e-07 6.790296534933627 -0.8301933518545421 down GQYTSGK(ub)GSSAVGLTAYVMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GQYTSGKGSSAVGLTAYVMK 20 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 6671200.0 1827700.0 2712800.0 2130700.0 True False 2396132.3994719787 2308060.8144115806 1910235.6031176103 1.0 0.9632442743648866 0.797216215405525 21.192276196476044 -6.942094023655961 0.6397869159595577 1.00181729060887 0.749543894474718 0.998425498714545 0.0035003798759335944 0.08682421576569824 0.05035604798040377 0.003464066134624537 0.014163113755982542 1.1426309313054477e-07 6.942094023655961 -0.252273396134152 GQYTSGK(ub)GSSAVGLTAYVMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GQYTSGKGSSAVGLTAYVMK 20 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 14429700.0 3382800.0 3185800.0 7861100.0 True False 3275414.865651106 4457906.553727525 5802042.082055079 1.0 1.3610204314809313 1.7713915091796213 21.64324622000821 -6.96945659272765 0.2708532533678356 0.8990340958160293 2.245728875196037 0.999977827291261 0.0014838888561362654 0.07647945323357246 0.009659521186063951 0.008002395824075793 0.03812214919205744 1.0728608737820947e-07 6.96945659272765 1.346694779380008 GQYTSGK(ub)GSSAVGLTAYVMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GQYTSGKGSSAVGLTAYVMK 20 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 6962100.0 1827700.0 1793800.0 3340600.0 True False 2503450.081735333 1714543.9846966474 2551619.081816622 1.0 0.6848724475097845 1.019241046758919 21.255486257998935 -11.042841454375978 12.338798224303996 1.4996975551510294 0.8520567471343511 0.20699279325169684 0.13650540902825567 0.04187289991806208 0.00014538679210104126 0.002949428095336131 0.04405693131947216 9.060633123422143e-12 11.042841454375978 -0.6476408080166783 GQYTSGK(ub)GSSAVGLTAYVMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQYTSGKGSSAVGLTAYVMK 20 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 11389800.0 3382800.0 5137300.0 2869700.0 True False 2812948.083449594 5109624.3452257905 3469741.0020063543 1.0 1.8164659260115885 1.2334891718837973 21.423651495442485 -10.086160049381174 5.1587073448476035 0.9999898631709272 1.5249775489487567 0.5195146925521124 0.23799926325655096 2.7747884887322776e-05 4.91595322742892e-06 0.23044624266375502 0.07681393191632167 8.200492780744635e-11 10.086160049381174 0.5249876857778295 GQYVK(ub)FLAQTA ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GQYVKFLAQTA 11 1 Q9BV57;Q9BV57-2;A0A0G2JQN5;H7C382 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 7537900.0 1633200.0 3171500.0 2733200.0 True False 1358078.1630276314 3154414.500006541 3304699.4831110486 1.0 2.322704676271539 2.433364715727199 20.373135084376056 -10.672424774072804 0.4748533823977772 1.1611183183954622e-21 2.431840052030568 0.9996165940307595 0.012750610120280288 2.193438603827353 0.22729964084067447 2.585785872181019 0.023608463236983516 2.126058576644608e-11 10.672424774072804 2.431840052030568 GQYVK(ub)FLAQTA ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GQYVKFLAQTA 11 1 Q9BV57;Q9BV57-2;A0A0G2JQN5;H7C382 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 21654200.0 3653900.0 4373300.0 13627000.0 True False 4730045.579136911 4129922.010560338 11147025.824827528 1.0 0.8731252038619727 2.3566423702118997 22.173422654892644 -6.886098401829708 1.0451609182504122 0.9126753506735584 2.4749079476935663 0.9782822796916723 0.09894861437130462 0.12236695146882832 0.24078351207477747 0.07247845977853475 0.17833388161572578 1.2998750208199068e-07 6.886098401829708 1.562232597020008 up GRDEVSK(ub)NQALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GRDEVSKNQALK 12 2 Q9UKY7;D6R9V8 Q9UKY7 CDV3 Protein CDV3 homolog 1 2637690.0 594880.0 1150500.0 892310.0 True False 779893.4408261145 978849.884613875 799982.3208419167 1.0 1.255107215130586 1.0257584933584296 19.572917492137716 -10.534923326100502 2.988641222177091 0.9942823209777725 1.140432854410594 0.3332890654957741 0.09363122519346286 67811325.64839548 68903294.15377074 3091543.4189861333 0.034896640066036475 2.917942125894648e-11 10.534923326100502 0.14615053343282147 GRDEVSK(ub)NQALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GRDEVSKNQALK 12 2 Q9UKY7;D6R9V8 Q9UKY7 CDV3 Protein CDV3 homolog 1 1410700.0 594880.0 0.0 815820.0 True False 814823.2120275282 0.0 623140.1183403084 1.0 0.0 0.7647549911958769 19.636127553660607 -10.820519580322442 9.811645591725025 1.010708406353821 0.38237749633844287 0.46513813930322734 0.3122099177794233 0.07028736605326609 0.001285735980925662 0.29053209923835216 0.10076531767337445 1.5117515399640844e-11 10.820519580322442 -0.6283309100153781 GRDEVSK(ub)NQALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GRDEVSKNQALK 12 2 Q9UKY7;D6R9V8 Q9UKY7 CDV3 Protein CDV3 homolog 1 4453430.0 1549100.0 2394700.0 509630.0 True False 1288145.2867659233 2381799.2757892637 616191.2767371155 1.0 1.849014470851435 0.47835541772167145 20.296863890009522 -6.739141989408179 1.6897350607682249 1.5056472825645326 0.47768092720723737 0.6011750400845645 0.35672642096331203 0.31934735550006177 1.789979533227508 0.16703179354987846 0.41028395826203906 1.8232994904128591e-07 6.739141989408179 -1.0279663553572953 GREEYEGPNKKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GREEYEGPNKKPR 13 3 P23246 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 2500630.0 573510.0 463720.0 1463400.0 False True 555304.2389735024 648885.8142678541 1080091.63894104 1.0 1.1685230702854712 1.945044829727257 19.082918883373313 -6.9416434311768205 0.6441013779223783 0.9914708468810233 2.1649699309309307 0.9983712379622106 0.016610039077911982 0.08702498484032843 0.05125665275135075 0.01637746838432417 0.06636480778768994 1.1438170575610637e-07 6.9416434311768205 1.1734990840499075 GRPCK(ub)IVEMSTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GRPCKIVEMSTSK 13 2 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4 I3L397 EIF5A;EIF5A2 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2 1 28360900.0 6885000.0 14513000.0 6962900.0 True False 9026301.674434846 12347716.971230915 6242445.90085306 1.0 1.3679707832282293 0.6915840092663323 23.105703566015286 -6.7589974124414445 1.616535746249019 1.2140063851735754 0.6892593140926954 0.6867568403744151 0.1547464526276497 0.28460099253688975 1.4656121693863298 0.07554246413587869 0.18169951414983718 1.7418172512363526e-07 6.7589974124414445 -0.52474707108088 GRPCK(ub)IVEMSTSK ddPTM_RPMI8226_Bortezomib_2h_R1 2 GRPCKIVEMSTSK 13 2 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4 I3L397 EIF5A;EIF5A2 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2 1 23448160.0 9412700.0 8326200.0 5709260.0 True False 9113898.99075149 11650895.080559384 4213833.5318713365 1.0 1.2783656141441069 0.462352450487701 23.119636950599673 -6.814617606640108 1.3948121950122618 1.1509009971610717 0.4464849952748996 0.8716082163938003 0.12136057450503807 0.20055936526686308 0.7680657581229952 0.06839502100123063 0.1579240002094646 1.5324361675334912e-07 6.814617606640108 -0.7044160018861721 down GRPCK(ub)IVEMSTSK ddPTM_RPMI8226_Bortezomib_8h_R1 2 GRPCKIVEMSTSK 13 2 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4 I3L397 EIF5A;EIF5A2 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2 1 60764700.0 10349000.0 20421900.0 29993800.0 True False 15700189.6132443 16777452.387967035 24065512.283250447 1.0 1.0686146346802068 1.532816665026094 23.904278647050436 -6.933350320515232 0.7187557207905317 0.9937430379442445 1.6367913402479648 0.9971568018870993 0.012619268697022262 0.0909349324101389 0.06942784292163853 0.011735149241368797 0.041255772612934484 1.1658687979923654e-07 6.933350320515232 0.6430483023037203 GRPCK(ub)IVEMSTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GRPCKIVEMSTSK 13 2 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4 I3L397 EIF5A;EIF5A2 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2 1 26439300.0 8036600.0 9735200.0 8667500.0 True False 11007948.200948814 9305066.67399866 6620415.012765845 1.0 0.8453043659123163 0.6014213450055305 23.392042250627803 -6.964417024827466 0.3679209700300572 1.0192024418013093 0.4190617284131263 0.9999006172716238 0.0016356314417112438 0.07815935864120312 0.01556092396202548 0.0032250855471614593 0.020736237540141325 1.0853829002541108e-07 6.964417024827466 -0.600140713388183 GRPCK(ub)IVEMSTSK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GRPCKIVEMSTSK 13 2 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4 I3L397 EIF5A;EIF5A2 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2 1 20880130.0 9412700.0 5043930.0 6423500.0 True False 7827077.103312633 5016757.347948284 7766624.1510916855 1.0 0.6409490134989286 0.992276433281159 22.90004222603395 -10.803672021220219 9.948701741553897 1.0020424935262338 0.8166127235783498 0.26648017362502496 0.14342881851917552 0.006555845987869402 0.000129372876849444 0.14011516996861242 0.04629145212424773 1.571549188752e-11 10.803672021220219 -0.18542976994788396 GRPCK(ub)IVEMSTSK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GRPCKIVEMSTSK 13 2 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4 I3L397 EIF5A;EIF5A2 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2 1 52635500.0 10349000.0 20287300.0 21999200.0 True False 13396984.509288112 19158293.921030063 17995571.330853883 1.0 1.4300452394900989 1.343255366039841 23.675404969142885 -10.013705799920173 4.639880624432745 0.999991527723449 1.38665030273412 0.9635872303149858 0.035431817552226644 18484641.105534796 1.1461307882624157 2025.6369274239833 0.012966717486191515 9.689340099629876e-11 10.013705799920173 0.3866587750106709 GRPQSK(ub)APDSTLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GRPQSKAPDSTLR 13 2 O60291-4;O60291;O60291-3;O60291-2;K7EPJ5 O60291-4 MGRN1 E3 ubiquitin-protein ligase MGRN1 1 2280760.0 249690.0 734970.0 1296100.0 True False 323228.6271257275 694068.2734094459 1060223.0991090457 1.0 2.1472982748507343 3.2801027202848796 18.302195452178026 -6.9712818864759765 0.22547784295588777 0.5124243670868409 4.94717014060801 0.9999907279995477 0.00283444173096023 0.07588892877372745 0.007524559459676606 0.030102133026091948 0.11352195331911122 1.0683612154822866e-07 6.9712818864759765 4.434745773521169 GRPSGK(ub)GIVEFSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GRPSGKGIVEFSGK 14 2 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 25438300.0 7613200.0 10155000.0 7670100.0 True False 9980978.926333677 8639913.583879972 6876471.62879447 1.0 0.8656378946041599 0.6889576342708912 23.25074989018796 -6.967353000718107 0.3150710302425807 1.025639398531468 0.5232984759057776 0.9999537514418368 0.000866201796632719 0.07717137435226815 0.012090512504566577 0.002733722013340695 0.015610671970831288 1.0780700953379654e-07 6.967353000718107 -0.5023409226256904 GRPSGK(ub)GIVEFSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GRPSGKGIVEFSGK 14 2 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 45184000.0 8153000.0 12955000.0 24076000.0 True False 7894187.477726566 18127999.059432495 17769773.335482065 1.0 2.2963730099621538 2.250994593885621 22.91235935128317 -10.143581479901304 5.306866619380156 0.9999636787390443 2.2736838019245122 0.9990489059417219 0.018525660789391534 7.961373231952623e-06 1.2847698954334527e-06 0.01793790190686981 0.005979131309250796 7.18486347345244e-11 10.143581479901304 1.273720123185468 GRPSGK(ub)GIVEFSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GRPSGKGIVEFSGK 14 2 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 28526200.0 4945400.0 5620800.0 17960000.0 True False 7502533.357168653 4617724.324489158 14410198.127852345 1.0 0.6154886762451957 1.9207109707927434 22.838946397558242 -6.827809728677527 1.3376104665903965 0.7942055399210552 1.9543009324034697 0.9014273723127414 0.17193783700880952 0.18353460629964768 0.642984489073795 0.10094548373452528 0.23234162042020723 1.4865867969644426e-07 6.827809728677527 1.1600953924824144 GRPSGK(ub)GIVEFSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GRPSGKGIVEFSGK 14 2 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 23647300.0 7613200.0 8087000.0 7947100.0 True False 10428005.778994052 7729689.599867196 6070158.655662125 1.0 0.7412433176281619 0.5821015814825995 23.313959951710853 -10.047680561899853 0.08195467931385927 1.8353009313712878 6.852181833026472e-13 0.9999654914820765 0.0010116389646184973 1.690008681472502 0.03908190558211884 0.589919839690054 0.30335436710104147 8.960235785063517e-11 10.047680561899853 -1.8353009313706026 GRPSGK(ub)GIVEFSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GRPSGKGIVEFSGK 14 2 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 36148600.0 8153000.0 19678000.0 8317600.0 True False 6779580.739140507 19571990.708222836 10056771.703762792 1.0 2.886902813212032 1.4833913911080225 22.692764626717445 -6.570478932578056 2.304478266747078 2.2922110072770754 1.486304706088178 0.0 0.8216988626521424 0.7284690578021891 7.262890123494599 0.3012195137147553 0.9210324943571834 2.6885682610886217e-07 6.570478932578056 -0.8059063011888974 GRPSGK(ub)GIVEFSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GRPSGKGIVEFSGK 14 2 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 21272800.0 4945400.0 4994400.0 11333000.0 True False 6401917.788407909 4716457.249569558 9270510.286399834 1.0 0.7367256821244642 1.4480833076591748 22.61007271965069 -6.8064854781524655 1.429077918539503 0.855908810030488 1.4595733516923233 0.8504970472444733 0.11354513731332891 0.21163181272541975 0.8524475286890278 0.062484073505511044 0.14479399207968713 1.5614012469032316e-07 6.8064854781524655 0.6036645416618353 GRPSGK(ub)GIVEFSGK(ub)PAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GRPSGKGIVEFSGKPAAR 18 3 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 2 10669000.0 3181800.0 4480900.0 3006300.0 True False 2645807.677639798 4456760.502310989 3634903.4304393185 1.0 1.6844612478737149 1.3738350905693368 21.335276766012807 -10.028176174997691 4.411141282575667 0.999974360809042 1.5291481692750803 0.7946259894208245 0.12681259794096772 16561571.727065451 9412664.347535852 4022.4717421129885 0.04341132645652085 9.371817546004514e-11 10.028176174997691 0.5291738084660383 GRPSGK(ub)GIVEFSGKPAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GRPSGKGIVEFSGKPAAR 18 3 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 20233800.0 5471000.0 8855900.0 5906900.0 True False 7172533.981239365 7534634.240027833 5295710.650985778 1.0 1.0504842862697596 0.7383319012272864 22.77405146737554 -6.865442082774236 1.1578637184255836 1.0279013808137596 0.721561592660445 0.959922553887272 0.027388896512139993 0.1413039209780517 0.3569229729709765 0.01840354965926031 0.043260367748975986 1.3631947888445984e-07 6.865442082774236 -0.30633978815331464 GRPSGK(ub)GIVEFSGKPAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GRPSGKGIVEFSGKPAAR 18 3 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 52191000.0 10539000.0 13302000.0 28350000.0 True False 10204445.213756928 18613557.9690136 20924284.518230483 1.0 1.8240636878445962 2.0505068212842974 23.282694413547517 -10.765155412892222 0.2595218061002383 1.6928121988927e-23 2.1536878835571893 0.9991812436893086 0.012916548130341444 2.543179648955245 0.13294683688043618 1.677695680140794 0.09824267253643394 1.717293741203421e-11 10.765155412892222 2.1536878835571893 GRPSGK(ub)GIVEFSGKPAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GRPSGKGIVEFSGKPAAR 18 3 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 103493000.0 16509000.0 16341000.0 70643000.0 True False 25045359.969567105 13424820.87718426 56680380.08607317 1.0 0.5360202805428594 2.2631090211897984 24.5780400113864 -6.835194563454698 1.304506150738469 0.7528251562214828 2.3147251477993525 0.9158754155530933 0.21167480262027308 0.1744867897122093 0.5788491552458834 0.12732768142814085 0.29307055755191286 1.4615222673854896e-07 6.835194563454698 1.5618999915778695 up GRPSGK(ub)GIVEFSGKPAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GRPSGKGIVEFSGKPAAR 18 3 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 24493800.0 5471000.0 10295000.0 8727800.0 True False 7493776.548215789 9840132.858987626 6666473.394683322 1.0 1.3131073225462648 0.8896013047347346 22.83726152889843 -6.708665577151804 1.799893236858312 1.192757357543596 0.8906340928821677 0.4587168297573012 0.1319703442825876 0.37780437009317647 2.385012424533419 0.058365637256933195 0.1485203726066918 1.955844949162424e-07 6.708665577151804 -0.30212326466142825 GRPSGK(ub)GIVEFSGKPAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GRPSGKGIVEFSGKPAAR 18 3 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 45466100.0 10539000.0 25626000.0 9301100.0 True False 8763645.45686272 25487947.65163723 11245917.006572584 1.0 2.9083727516244835 1.2832464596985746 23.063099688981794 -6.606994987161657 2.165303616525496 2.2775678347414323 1.2889548051961746 0.041069046945039434 0.8233955476393376 0.6209233421769745 5.51242431524294 0.3145449800973138 0.9143514452800564 2.4717526750242067e-07 6.606994987161657 -0.9886130295452578 GRPSGK(ub)GIVEFSGKPAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GRPSGKGIVEFSGKPAAR 18 3 Q15233;Q15233-2;H7C367;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 88976000.0 16509000.0 16866000.0 55601000.0 True False 21371225.941041384 15927392.273594445 45482188.514437184 1.0 0.7452727474565425 2.1281974482845656 24.34916633347885 -6.859153319113753 1.1899582167150244 0.8620866076831997 2.194104697013898 0.9526039465092544 0.1308291812040056 0.14768201211092405 0.39783840036675505 0.08577780306888959 0.2000504070995743 1.3830780243169875e-07 6.859153319113753 1.3320180893306983 up GRPTSTNPIASIFAWTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GRPTSTNPIASIFAWTR 17 1 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 39202700.0 6420700.0 22045000.0 10737000.0 False True 8417599.878147256 18755971.930736963 9626038.2365766 1.0 2.228185254971423 1.1435609171168308 23.004977503625135 -6.616222447714431 2.130780685322427 1.817079724041612 1.1476151686336298 0.07023647245491371 0.5286709578865896 0.595585670974256 5.133006459900623 0.2042523467441966 0.5863996241022439 2.4197893015875635e-07 6.616222447714431 -0.6694645554079823 GRPTSTNPIASIFAWTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GRPTSTNPIASIFAWTR 17 1 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 56429000.0 19710000.0 16051000.0 20668000.0 False True 19084316.83870855 22460248.004859213 15254430.773290562 1.0 1.1768955731914539 0.7993176230626258 24.18588420753484 -6.779277577290445 1.5384383362228058 1.1002542316010433 0.7963803829871626 0.7649289340641275 0.07478554583524026 0.25168638004177335 1.176515661720137 0.03828747941930473 0.09040639571426835 1.6623498276262163e-07 6.779277577290445 -0.30387384861388067 GRPTSTNPIASIFAWTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GRPTSTNPIASIFAWTR 17 1 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 45209000.0 11953000.0 11992000.0 21264000.0 False True 18133574.88135175 9851933.906076347 17061161.079657707 1.0 0.5432979415552475 0.9408603207745377 24.112160032492135 -10.200134851431033 7.835755452337631 1.0000001392960443 0.7420791311648927 0.35945831712864684 0.16230416166902129 3.9487387829488057e-07 4.0344911439628135e-08 0.15715041309210862 0.052383442930356336 6.307614582879472e-11 10.200134851431033 -0.2579210081311516 GRPTSTNPIASIFAWTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GRPTSTNPIASIFAWTR 17 1 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 89454700.0 6420700.0 44297000.0 38737000.0 False True 8794606.302893285 42339812.06940983 29588118.413557556 1.0 4.8142930577211525 3.364348260117515 23.068187565148026 -9.532347019595477 10.816888434006703 1.0000000035408623 4.089320661888413 0.8582138692724757 0.5919374848886567 0.0 0.0 0.5731410052424181 0.19104700174747263 2.9353032836233985e-10 9.532347019595477 3.089320658347551 GRPTSTNPIASIFAWTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GRPTSTNPIASIFAWTR 17 1 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 48396000.0 19710000.0 13109000.0 15577000.0 False True 16389738.301049866 13038379.215067241 18834078.680089545 1.0 0.7955208909120929 1.149138462990779 23.966289482969117 -6.749893625186129 1.6500358337059673 0.8797520009290982 1.1498449054950242 0.6486232816808029 0.08592316816410847 0.3002169201643168 1.6081203629499978 0.0411348661482223 0.09988342515110443 1.7787150299182517e-07 6.749893625186129 0.27009290456592594 GRPTSTNPIASIFAWTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GRPTSTNPIASIFAWTR 17 1 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 62918000.0 11953000.0 27111000.0 23854000.0 False True 15473394.12885505 25602249.01751569 19512816.762709044 1.0 1.6545981317552156 1.261056016554326 23.883286354584584 -10.110860308145407 4.256909549688816 0.9999352095618688 1.4578270740316226 0.6434314478217456 0.16066289605996614 37613517.282832436 48163842.079926066 30100.11781970187 0.058796595256341816 7.747109453518526e-11 10.110860308145407 0.45789186446975383 GRPYTLSVALPGSILDNAQSPELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GRPYTLSVALPGSILDNAQSPELR 24 1 Q5T280 Q5T280 C9orf114 Putative methyltransferase C9orf114 0 18217500.0 10224000.0 4513300.0 3480200.0 False True 9899444.71633466 6315484.226548573 2568631.2162379427 1.0 0.6379634825504562 0.25947225221628356 23.238916172550987 -7.454705681338525 0.32603690528439166 1.068907090174217 4.099839087016901e-13 0.999627623706996 0.005834346871007727 0.11969721925868707 0.032485266009161566 0.019113332304421173 0.06202023143459222 3.509896568726321e-08 7.454705681338525 -1.0689070901738071 down GRPYTLSVALPGSILDNAQSPELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GRPYTLSVALPGSILDNAQSPELR 24 1 Q5T280 Q5T280 C9orf114 Putative methyltransferase C9orf114 0 15531500.0 10224000.0 2789600.0 2517900.0 False True 8501708.99999664 2774571.87110775 3044381.248545773 1.0 0.32635460365778773 0.35809050257389147 23.019321447985263 -9.98099521292904 5.222609813424542 1.0000024508167125 0.34222255313529 0.9982572003943457 0.01295612649695913 7662639.332411151 14644164.675455708 181.15543286796307 0.004435226939425265 1.0447317348572965e-10 9.98099521292904 -0.6577798976814224 GSADPLNSAFHLTYNMVLNLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSADPLNSAFHLTYNMVLNLLR 22 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 781040000.0 284450000.0 288100000.0 208490000.0 False True 431531446.0805241 236686304.06442595 167281860.11558664 1.0 0.5484798528917869 0.3876469759850867 28.68489045280537 -13.999999997229683 0.14376853465487202 3.165088819262408 0.19736330824963633 0.9995883462401616 0.005259197698815091 11.939731587569282 0.11905774464425922 7.238295757700425 0.17057838465186556 1.0000000063788913e-14 13.999999997229683 -2.967725511012772 GSADYSMEAKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSADYSMEAKK 11 1 Q04726;A0A0D9SES8;H0YL70;H0YKN8;Q04726-2;Q04726-7;Q04726-6;Q04726-5;Q04726-3;Q04726-4;H0YKT5;H0YLI3;H0YNT2;H0YLW9;H0YKH0 Q04726 TLE3 Transducin-like enhancer protein 3 1 2624030.0 872470.0 1358100.0 393460.0 True False 725497.4619744789 1350783.6457382562 475730.6668465066 1.0 1.8618723242146549 0.6557302978728291 19.4686110417223 -6.714874148358501 1.7779516091090624 1.5272008178975391 0.6581506022671686 0.4881857955587151 0.362924115588748 0.36534895323050715 2.254188277796109 0.16226631097988267 0.4097959613493856 1.9280835602290434e-07 6.714874148358501 -0.8690502156303705 GSAFAIGSDGLCCQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSAFAIGSDGLCCQSR 16 0 Q92499;F1T0B3;A0A087X2G1 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 16538400.0 3598700.0 5391700.0 7548000.0 False True 4717930.549860376 4587279.376681987 6767005.365528561 1.0 0.9723075251325488 1.4343164431975002 22.16972275091353 -6.892653952295964 1.0065308424602477 0.9767320010886398 1.4761859140729536 0.9825439790550206 0.027952649962533854 0.11701703413090227 0.2094714380250568 0.021082772343298938 0.0530886243351273 1.280401126908154e-07 6.892653952295964 0.49945391298431385 GSAFAIGSDGLCCQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSAFAIGSDGLCCQSR 16 0 Q92499;F1T0B3;A0A087X2G1 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 14598200.0 3598700.0 4113500.0 6886000.0 False True 4929236.64121078 3931751.9684745558 5259668.621621645 1.0 0.7976391183176774 1.0670351221623844 22.23293281243642 -6.705749989623618 1.8107543787104687 0.8750519744278141 1.0663149620497805 0.44469644677813847 0.08533315512768516 0.3836929297274678 2.4497196480093093 0.037543915447158675 0.09585969700513709 1.9690194692709605e-07 6.705749989623618 0.19126298762196636 GSAFSTSISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSAFSTSISK 10 0 K7ER00;Q9Y285;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 8619800.0 1961200.0 1350000.0 5308600.0 False True 1898942.7795066067 1889062.0401569945 3918118.405413692 1.0 0.9947967155955171 2.0633156763321314 20.856765003002316 -6.905801317129186 0.9238292297497468 0.9623645728882136 2.1896968241041597 0.989238815345777 0.052125613747739295 0.10726142142213049 0.15430316304344388 0.04180901910505761 0.11231856476237397 1.2422204738792457e-07 6.905801317129186 1.227332251215946 up GSAFSTSISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSAFSTSISK 10 0 K7ER00;Q9Y285;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 4856900.0 1961200.0 1596600.0 1299100.0 False True 1630824.6958913752 1587998.798899711 1570735.803640263 1.0 0.9737397299050243 0.9631542909532229 20.637170278436592 -13.999999999686214 0.1251807885840964 1.1248356284938166 0.9473811247272409 0.9996678079755162 0.00028225065896978965 11.94691175864237 0.1095214984992635 0.3687151179613331 0.01400744530944805 1.0000000007225198e-14 13.999999999686214 -0.17745450376657568 GSAFSTSISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSAFSTSISK 10 0 K7ER00;Q9Y285;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 6673100.0 1636400.0 2726300.0 2310400.0 False True 2118352.058266409 2574579.0083896895 1889930.9067059157 1.0 1.215368804417072 0.8921703544653357 21.014510946429017 -6.727069241094822 1.7336910881399885 1.1300282389023988 0.8924556104924188 0.5457069082890011 0.09055886807118012 0.34177011409685054 2.011053701747096 0.04141525122533621 0.10312072959190535 1.8746955949356124e-07 6.727069241094822 -0.23757262840997995 GSAFSTSISK(ub)QETELSPEMISSGSWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSAFSTSISKQETELSPEMISSGSWR 26 1 K7ER00;Q9Y285;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 1 15645500.0 2626000.0 3405000.0 9614500.0 True False 2542639.0673997286 4764634.25684042 7096174.0211825995 1.0 1.8738932780235502 2.790869578056007 21.27789525249688 -6.970517857055429 0.24550102085248018 0.6924049741578839 3.9990626256141946 0.9999861450519855 0.0027216463576776907 0.07613500384661717 0.008426631529592542 0.02109162024256623 0.08854460510610383 1.0702423764338781e-07 6.970517857055429 3.3066576514563106 GSAFSTSISK(ub)QETELSPEMISSGSWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSAFSTSISKQETELSPEMISSGSWR 26 1 K7ER00;Q9Y285;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 1 13582900.0 2626000.0 3382600.0 7574300.0 True False 2183635.3515249593 3364377.262406473 9158051.110393673 1.0 1.5407230241335548 4.193947081868808 21.058300527931156 -6.94022574978729 0.6574590643720626 0.9703300421838535 4.914216102819656 0.998193331341433 0.05932661215879828 0.08766377549265882 0.054141601682780066 0.057849285349838235 0.22813146226510367 1.1475569570391132e-07 6.94022574978729 3.943886060635802 up GSAK(ub)ELLQHPFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSAKELLQHPFLK 13 1 Q13177;A0A087X294;O75914-2;O75914;O75914-4;O75914-3 Q13177 PAK2;PAK3 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34;Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase PAK 3 1 6618000.0 1382500.0 2206600.0 3028900.0 True False 1812470.8881490445 1877383.881259431 2715498.4832603936 1.0 1.0358146404087503 1.4982301238689417 20.78952639211503 -6.922362584716562 0.8069907886019337 0.9906404626859683 1.5770128561205867 0.9948130337477445 0.01634132293693853 0.09680079189812084 0.09854950892189945 0.014258994863489154 0.04372816507034389 1.1957418109484715e-07 6.922362584716562 0.5863723934346184 GSATDDFFK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSATDDFFKK 10 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 17166100.0 7027900.0 6652600.0 3485600.0 True False 9213644.958280414 5660058.0116316965 3124943.548236139 1.0 0.614312580662763 0.339164745590475 23.135340575037407 -8.019950048696822 0.20623749186247892 1.2423784508159192 7.658862215707745e-13 0.9998149582365669 0.0036869547402213457 0.10067524864661634 0.03686673171511261 0.07948229960848763 0.10330797591197459 9.551024328411125e-09 8.019950048696822 -1.2423784508151534 down GSATDDFFK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSATDDFFKK 10 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 38175000.0 13397000.0 14208000.0 10570000.0 True False 20324228.451892372 11672471.392389316 8480834.867004424 1.0 0.5743131366594387 0.4172770881354062 24.276697249980163 -13.999999999999952 0.1385746994986921 3.0310185007094304 0.21955874287457325 0.9996086767965361 0.004869876949192367 11.932840131460335 0.11652523893439534 6.558959579786632 0.1765941535743045 1.0000000000001104e-14 13.999999999999952 -2.8114597578348572 GSATDDFFK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSATDDFFKK 10 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 16696100.0 7027900.0 5481300.0 4186900.0 True False 9626304.551856289 5239118.041764823 3198040.4519122387 1.0 0.5442501858882636 0.3322189148166463 23.1985506365603 -11.702589560630084 0.13142442607824018 2.236215338975218 1.1382972743279632e-19 0.9997179355860594 0.0046791378302633605 4.748116747516055 0.08751217665390938 1.9038861933472935 0.2455517092820267 1.983400595861229e-12 11.702589560630084 -2.236215338975218 GSATDDFFK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSATDDFFKK 10 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 41869000.0 13397000.0 15181000.0 13291000.0 True False 17342680.594350476 14336164.00482849 10872174.377176398 1.0 0.8266406064987795 0.6269027626973711 24.047823572072613 -6.969270675235243 0.275047261851042 1.04671150359419 0.4007862573897961 0.9999761210210457 0.0007449082004735198 0.07654006185947422 0.009874073842436307 0.0037978960538431615 0.018450897857121493 1.073320254022999e-07 6.969270675235243 -0.645925246204394 GSCPFGGNCFYK(ub)HAYPDGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSCPFGGNCFYKHAYPDGR 19 1 Q9UHC7-2;Q9UHC7 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 25803200.0 8369300.0 13217000.0 4216900.0 True False 10972233.348416489 11245075.119462483 3780575.6393610737 1.0 1.024866566576017 0.3445584430545023 23.387353873885814 -6.898413447758568 0.9712196419192207 1.0295291436552245 0.2753996982192122 0.9857610160700416 0.037588411205354076 0.11258340192899552 0.18406888520706824 0.029110717892016625 0.07515777517280321 1.2635328931156546e-07 6.898413447758568 -0.7541294454360123 down GSCPFGGNCFYK(ub)HAYPDGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSCPFGGNCFYKHAYPDGR 19 1 Q9UHC7-2;Q9UHC7 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 110235900.0 20782900.0 34498000.0 54955000.0 True False 31529178.73350999 28341562.365895763 44093120.1623678 1.0 0.898899479921234 1.3984861621373137 24.91018425565608 -6.854047124605412 1.215547307856616 0.9458046423541385 1.4200555043389333 0.9459689659705546 0.0501302277203236 0.1530649980331313 0.4332046449609532 0.03223562609117481 0.07480758117472833 1.3994354638112088e-07 6.854047124605412 0.4742508619847948 GSCPFGGNCFYK(ub)HAYPDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSCPFGGNCFYKHAYPDGR 19 1 Q9UHC7-2;Q9UHC7 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 23624400.0 8369300.0 10448700.0 4806400.0 True False 11463656.381828256 9987041.88476969 3671227.3109152257 1.0 0.8711916645199486 0.32024924584574194 23.450563935408706 -6.943338054174344 0.6277418834893939 1.0060106804993534 0.1558521894450732 0.9985692376410176 0.011151123661092565 0.08627627692722475 0.04791901664623374 0.011152015479375936 0.04676621951412186 1.1393625641855619e-07 6.943338054174344 -0.8501584910542802 down GSCPFGGNCFYK(ub)HAYPDGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSCPFGGNCFYKHAYPDGR 19 1 Q9UHC7-2;Q9UHC7 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 125236400.0 20782900.0 42435500.0 62018000.0 True False 26903873.742205415 40073927.121197514 50731360.35841738 1.0 1.4895225685783529 1.8856526329452932 24.68131057774853 -6.973532109713078 0.15168681378933085 0.550240231921452 2.835368662793529 0.9999984710016395 0.0004478768469210384 0.07517239997599344 0.004643994042009625 0.01988031290208403 0.04908062188427075 1.0628399989268643e-07 6.973532109713078 2.285128430872077 GSCSTEVEK(ub)ETQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSCSTEVEKETQEK 14 1 O75348 O75348 ATP6V1G1 V-type proton ATPase subunit G 1 1 2547470.0 882610.0 499060.0 1165800.0 True False 854592.0286662877 698337.2605635185 860442.0067496669 1.0 0.8171586407766676 1.006845345951224 19.70487633456694 -11.136173970877822 9.943575728625223 2.9885157501325894 0.9120019933580287 0.22297078586313857 0.07743927311123551 0.04076629492688707 0.0005582818327074793 0.0008953951149522716 0.02499341792518523 7.308462604326521e-12 11.136173970877822 -2.0765137567745606 GSDEPPVFLEIHYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSDEPPVFLEIHYK 14 0 P28838-2;P28838;H0Y9Q1 P28838-2 LAP3 Cytosol aminopeptidase 0 27104100.0 9991600.0 9150400.0 7962100.0 False True 13099084.358792046 7785195.987979846 7138258.269856256 1.0 0.594331311619843 0.5449433009464582 23.642962633440042 -13.999999999999998 0.297037859265922 4.638088145871505 0.5324144141970255 0.9996432140668433 0.0038509335416128283 16.3979965372105 0.17300452059910187 36.603437102198356 0.018078890898354825 1.0000000000000041e-14 13.999999999999998 -4.10567373167448 GSDEPPVFLEIHYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSDEPPVFLEIHYK 14 0 P28838-2;P28838;H0Y9Q1 P28838-2 LAP3 Cytosol aminopeptidase 0 23966400.0 8035000.0 5643400.0 10288000.0 False True 7779933.323136643 7896839.049942209 7593264.166615696 1.0 1.0150265718162266 0.9760063295188129 22.89132636016645 -6.802291424994687 1.4464121625332036 1.0082668919885964 0.9754359237352966 0.8388137297986167 0.006451601611594139 0.21750155614285985 0.8980806424698166 0.0035085124754127713 0.00814885057481137 1.5765529989763127e-07 6.802291424994687 -0.032830968253299786 GSDEPPVFLEIHYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSDEPPVFLEIHYK 14 0 P28838-2;P28838;H0Y9Q1 P28838-2 LAP3 Cytosol aminopeptidase 0 67031200.0 18577200.0 32016000.0 16438000.0 False True 28182970.575240318 26302494.657850258 13189022.094968664 1.0 0.9332761636190998 0.46797842192531897 24.74832034854539 -6.932742847794719 0.7239217593497003 1.0064058792436235 0.3654211189058837 0.9970504277941196 0.012852094927413139 0.0912383947038125 0.07088454985152168 0.011906097969811002 0.04148470547425411 1.1675007069263631e-07 6.932742847794719 -0.6409847603377398 down GSDEPPVFLEIHYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSDEPPVFLEIHYK 14 0 P28838-2;P28838;H0Y9Q1 P28838-2 LAP3 Cytosol aminopeptidase 0 27864100.0 9991600.0 8221300.0 9651200.0 False True 13685764.532837309 7858055.781796496 7371785.33270329 1.0 0.574177333165572 0.5386462199474203 23.706172694962934 -13.999999999999998 0.35185005735965724 6.296815538746597 0.5338568436707061 0.9997582178161213 0.003259324551643872 20.845629167739272 0.19108226705247514 82.59776307121774 0.01053489272362181 1.0000000000000041e-14 13.999999999999998 -5.762958695075891 GSDEPPVFLEIHYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSDEPPVFLEIHYK 14 0 P28838-2;P28838;H0Y9Q1 P28838-2 LAP3 Cytosol aminopeptidase 0 18006700.0 8035000.0 5800300.0 4171400.0 False True 6681458.510854171 5769052.632630592 5043620.453625579 1.0 0.8634421097217987 0.7548681841595082 22.671731635600725 -6.973713748630691 0.1440674109861941 1.1372220618836713 0.478246794694355 0.9999987778744589 0.00011072191917561291 0.07511512811261199 0.004379077078483346 0.005883891109590389 0.01388698754270631 1.0623955706656374e-07 6.973713748630691 -0.6589752671893163 GSDEPPVFLEIHYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSDEPPVFLEIHYK 14 0 P28838-2;P28838;H0Y9Q1 P28838-2 LAP3 Cytosol aminopeptidase 0 49498200.0 18577200.0 19393000.0 11528000.0 False True 24048551.611358307 18313762.50218294 9430022.2872688 1.0 0.7615328689289218 0.39212433412476 24.51944667063784 -6.964716486819792 0.3628859546557985 1.030800688187308 0.11014034553178427 0.9999071799673788 0.0024093041574661765 0.07805730435952694 0.015200028312097477 0.004928301377974799 0.0314985308236945 1.0846347468589881e-07 6.964716486819792 -0.9206603426555237 down GSDFDCELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSDFDCELR 9 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 47421400.0 2054400.0 16910000.0 28457000.0 False True 2693338.2948379004 14387093.914663734 25512542.618819088 1.0 5.341732949863109 9.472461245479959 21.3609640192279 -7.48313347126522 0.2976906195310892 4.174451297674034e-18 12.802570246852836 0.999666119075851 0.06320837971938266 0.13582271400155038 0.03320351816458166 0.286132590031193 0.8289639741164676 3.287505807795993e-08 7.48313347126522 12.802570246852836 GSDFDCELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSDFDCELR 9 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 11941000.0 6728200.0 1188600.0 4024200.0 False True 6514616.973830473 1663214.1784671159 2970141.2965877624 1.0 0.2553049834162663 0.4559195588196454 22.635248927519008 -10.644676916004798 7.210015459631048 1.001767104906407 0.3556122711191645 0.9322333024678483 0.08190055745056327 0.002330785230532633 0.00011486525653793648 0.07944882648788962 0.02643329125426129 2.26632966760516e-11 10.644676916004798 -0.6461548337872425 GSDFDCELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSDFDCELR 9 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 44781400.0 2054400.0 25164000.0 17563000.0 False True 2813967.1980724763 24052171.273779925 13414981.12133909 1.0 8.547424181154382 4.7672841142313755 21.42417408075079 -9.733707795174192 8.242950236134247 1.0005300906572037 6.657353877199705 0.7491478292243945 1.5432357503823921 0.0 0.0 1.4942316209214468 0.4980771921378226 1.8462572121108718e-10 9.733707795174192 5.6568237865425015 GSDGAPDTGYLWHVPLTFITSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSDGAPDTGYLWHVPLTFITSK 22 0 Q9NZ08;Q9NZ08-2 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 3155450.0 939040.0 1310300.0 906110.0 False True 1231090.533676297 1114808.347509395 812354.4292208654 1.0 0.9055453819308815 0.6598657101155697 20.23150542999555 -6.9546071243977075 0.5057438159910235 1.0046845508610651 0.5500260938474093 0.9995149868698424 0.0031572370440258422 0.08168682866734323 0.028701727967123673 0.0036638200378324476 0.020271383488383567 1.1101786615127663e-07 6.9546071243977075 -0.4546584570136558 GSDGAPDTGYLWHVPLTFITSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSDGAPDTGYLWHVPLTFITSK 22 0 Q9NZ08;Q9NZ08-2 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 5455840.0 939040.0 1537300.0 2979500.0 False True 1286228.4646018208 1469377.0028287203 2275803.464728679 1.0 1.1423919181290991 1.7693617637619317 20.294715491518442 -6.942676168508027 0.6341853158013209 0.9931562021126891 1.952630549047948 0.9984937597084288 0.012970904280178787 0.08656682276004632 0.049208582588071925 0.01289862805273687 0.05335845500210012 1.1411003313848718e-07 6.942676168508027 0.959474346935259 GSDPSTHQRPPSEMADFLSDAIPGLK(ub)INQQEEPGFEVITR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSDPSTHQRPPSEMADFLSDAIPGLKINQQEEPGFEVITR 40 2 Q8TC07-2;Q8TC07-3;Q8TC07;C9JA93 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 124198000.0 19218000.0 71450000.0 33530000.0 True False 29155111.023995463 58699189.258601926 26902780.803278904 1.0 2.0133413043871062 0.9227466423001158 24.797245480831723 -6.662627141637753 1.9631936735181714 1.6508365320639293 0.9272310542152216 0.2470279138353535 0.4311836027279942 0.4782194680004669 3.5457159114623384 0.17726139508007868 0.4782532082820922 2.1745673265851297e-07 6.662627141637753 -0.7236054778487078 GSDSIAYDK(ub)GEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSDSIAYDKGEK 12 1 E7EV99;E7ENY0;P35611-2;P35611-6;P35611;P35611-3;P35611-4;A0A0A0MSR2;P35611-5 E7EV99 ADD1 Alpha-adducin 1 5342200.0 1003700.0 1497400.0 2841100.0 True False 1522686.2802988999 1230177.2707604 2279555.339701631 1.0 0.8078993596231254 1.4970617186188606 20.538187302693252 -6.832331155343601 1.3175681598503195 0.8975112190118514 1.5164911676651012 0.9104383338107512 0.08690348367863723 0.17795217766009933 0.6033599550388338 0.05177576435702719 0.1191426376702389 1.4711902723950635e-07 6.832331155343601 0.6189799486532498 GSDSIAYDK(ub)GEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSDSIAYDKGEK 12 1 E7EV99;E7ENY0;P35611-2;P35611-6;P35611;P35611-3;P35611-4;A0A0A0MSR2;P35611-5 E7EV99 ADD1 Alpha-adducin 1 2536330.0 649520.0 1071100.0 815710.0 True False 540104.6586148094 1065329.771703297 986271.1895830942 1.0 1.9724506254686214 1.8260742133062786 19.042879466591735 -10.055367809380396 4.643902240730098 0.9999652142819295 1.8992624191953764 0.9805156859043509 0.059757920146746364 20706429.881432563 0.44568155988462077 8171.651577762408 0.02045672551603621 8.803030176773056e-11 10.055367809380396 0.8992972049134469 GSDSIAYDK(ub)GEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSDSIAYDKGEK 12 1 E7EV99;E7ENY0;P35611-2;P35611-6;P35611;P35611-3;P35611-4;A0A0A0MSR2;P35611-5 E7EV99 ADD1 Alpha-adducin 1 5521300.0 1003700.0 1756500.0 2761100.0 True False 1299309.4358848666 1658749.2309124074 2258608.1312784394 1.0 1.2766391015876462 1.7383142682560935 20.309313624785702 -6.963424100600458 0.3841441907141171 0.969728546223522 2.0616586723488175 0.9998768769823673 0.00337935676746027 0.07849992998224964 0.01677155433032796 0.005985121303731395 0.03893554977627353 1.0878672419479416e-07 6.963424100600458 1.0919301261252956 GSDSLIK(ub)GK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSDSLIKGK 9 1 Q99623;Q99623-2 Q99623 PHB2 Prohibitin-2 1 4731100.0 1110600.0 1696900.0 1923600.0 True False 1456007.355065699 1443729.1344643943 1724564.324474132 1.0 0.9915671987791912 1.1844475362532183 20.473586212697327 -6.8966768680294654 0.9820454354088303 0.9912333051026576 1.2033804819328426 0.9848389749864231 0.010959026775674422 0.1138926393884023 0.19153944581313817 0.00841919541036456 0.021561804281643674 1.2685953990741566e-07 6.8966768680294654 0.21214717683018502 GSDSLIK(ub)GK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSDSLIKGK 9 1 Q99623;Q99623-2 Q99623 PHB2 Prohibitin-2 1 8465900.0 2518100.0 3376600.0 2571200.0 True False 2438164.293838253 4724893.988736377 1897725.5856534087 1.0 1.9378899119625224 0.7783419642594862 21.217363913460975 -6.691478940642849 1.8609592557400028 1.5871684906613106 0.7822512217551647 0.377472957333999 0.3965411471939348 0.4134828439173172 2.7774082159091287 0.17038440796318768 0.4429004236640561 2.0347968627152914e-07 6.691478940642849 -0.8049172689061459 GSDSLIK(ub)GK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSDSLIKGK 9 1 Q99623;Q99623-2 Q99623 PHB2 Prohibitin-2 1 3534640.0 1110600.0 1430800.0 993240.0 True False 1521218.8328364934 1367582.5249771236 758657.1684199069 1.0 0.8990044663246137 0.4987166553843541 20.53679627422022 -6.945085801563054 0.6104179486588347 1.0044250090989064 0.37243543573648596 0.998757002720813 0.007631737979324516 0.08552114278290956 0.04460626013811329 0.007754419626910379 0.03375826040533965 1.134786598955925e-07 6.945085801563054 -0.6319895733624205 down GSDSLIK(ub)GK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSDSLIKGK 9 1 Q99623;Q99623-2 Q99623 PHB2 Prohibitin-2 1 6577200.0 2518100.0 2639600.0 1419500.0 True False 2093911.720744477 2625379.9508804255 1716310.8869735587 1.0 1.2538159679181644 0.8196672619814819 20.99776918889525 -6.748249088190902 1.6564171700778543 1.1495600590369395 0.8189229703384335 0.641372599274777 0.10664694446511487 0.30310493574375014 1.6357066352110075 0.05087367373559054 0.12373096418542197 1.785463234481896e-07 6.748249088190902 -0.33063708869850594 GSEFMFEK(ub)APAHHPAAISTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSEFMFEKAPAHHPAAISTAK 21 1 Q5JTH9-2;Q5JTH9-3;Q5JTH9 Q5JTH9-2 RRP12 RRP12-like protein 1 22468700.0 2190300.0 4016400.0 16262000.0 True False 2835386.527267733 3792883.8093006485 13302482.862210726 1.0 1.3376955038844702 4.691594156310467 21.435113989839497 -6.926307955591173 0.7764993817332517 0.9414144777637804 5.319576639634813 0.9957615037215855 0.10848569710202485 0.09460083763238727 0.08740783397067775 0.09674521775221083 0.30985901258284126 1.1849282247577922e-07 6.926307955591173 4.378162161871033 up GSEHLNSYEAEWDMVNTVSFK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSEHLNSYEAEWDMVNTVSFKR 22 1 Q8TC07-2;Q8TC07-3;Q8TC07;F8WCB5 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 8261500.0 2205000.0 1402600.0 4653900.0 True False 2135003.4819559776 1962665.4944623713 3434903.975992687 1.0 0.9192797627965836 1.6088516974435139 21.025806992048874 -6.877718618754782 1.092390907551922 0.9513265363482878 1.655642618941363 0.9718005322727246 0.05168968059925363 0.12967264208325313 0.2846314011090899 0.03652043411826469 0.08782982148966727 1.3251998597439618e-07 6.877718618754782 0.7043160825930753 GSELEITLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSELEITLTR 10 0 A0A0A0MSX9;P41252;J3KR24;Q5TCC6 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 10136500.0 2463300.0 4651900.0 3021300.0 False True 3188790.4089022516 4393017.675651251 2471454.4011559016 1.0 1.377643906412638 0.7750444790150712 21.60457784534824 -6.737292171181948 1.6966387823597116 1.2254048040426564 0.7748999959470428 0.592653968153207 0.15868393660610652 0.3227674633196574 1.823248629297506 0.07402267115936219 0.18218571433631786 1.8310821492126814e-07 6.737292171181948 -0.45050480809561355 GSELQNYFTK(ub)ILEDDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSELQNYFTKILEDDLK 17 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 108814000.0 14262000.0 17156000.0 77396000.0 True False 21636496.69186302 14094377.75956019 62098646.67612815 1.0 0.6514168148515816 2.8700878686835654 24.366963585999475 -6.866737786539471 1.1512947938916336 0.8062749609221339 2.9921718855495083 0.9613130682961176 0.19161140445337274 0.14001669680776194 0.34892473170668753 0.1294093646211861 0.3047451997025798 1.3591338015015852e-07 6.866737786539471 2.1858969246273743 up GSELQNYFTK(ub)ILEDDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSELQNYFTKILEDDLK 17 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 83555400.0 14262000.0 14407000.0 54886400.0 True False 18462440.14604959 13605237.785229161 44897638.38202204 1.0 0.7369143882175443 2.4318366384320433 24.138089908091924 -6.867263821994193 1.1485498715975626 0.8534223725776985 2.526039075935412 0.9618710498728018 0.14542838549057444 0.13950115427794324 0.3456676504190185 0.0984253279909638 0.23196860623004556 1.3574885589719965e-07 6.867263821994193 1.6726167033577135 up GSESHK(ub)MIDLSGNPVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSESHKMIDLSGNPVLR 17 1 H3BUR9;B3KY94;O14735-3;O14735 H3BUR9 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1 12360900.0 2876400.0 3168900.0 6315600.0 True False 3770988.2550972244 2696112.472275452 5662122.295513014 1.0 0.7149617792182544 1.5014956060548728 21.846511226475887 -6.808652729085302 1.4199790557988488 0.8443973908518363 1.514859480794861 0.8562950181524428 0.12325135042948154 0.20866888740420242 0.8294750261978535 0.06825037842260744 0.15799110566710342 1.553628827375032e-07 6.808652729085302 0.6704620899430247 GSESHK(ub)MIDLSGNPVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSESHKMIDLSGNPVLR 17 1 H3BUR9;B3KY94;O14735-3;O14735 H3BUR9 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1 20871600.0 3571100.0 6780500.0 10520000.0 True False 3457737.385221313 9487989.009840371 7764496.406764889 1.0 2.7439877448162795 2.245542544656821 21.721396869933578 -10.32408350127777 6.230552878284304 0.9999081241217838 2.49476514473652 0.923022719075355 0.20348940085501904 0.00025973828517936 2.8177479406560926e-05 0.19703953029135132 0.06567592172010082 4.7415081208920297e-11 10.32408350127777 1.494857020614736 GSESHK(ub)MIDLSGNPVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSESHKMIDLSGNPVLR 17 1 H3BUR9;B3KY94;O14735-3;O14735 H3BUR9 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1 17839400.0 2876400.0 3563000.0 11400000.0 True False 3939882.8117872234 3405574.878734617 8707554.790369831 1.0 0.8643848158493243 2.2101050224942806 21.909721287998778 -6.882087894379098 1.068126093356367 0.9133928369584406 2.3093621905919313 0.9753292744875438 0.09501940063786686 0.12579489817900646 0.2612679075881486 0.06839529255345697 0.16630490289998134 1.311934357249795e-07 6.882087894379098 1.3959693536334905 up GSESHK(ub)MIDLSGNPVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSESHKMIDLSGNPVLR 17 1 H3BUR9;B3KY94;O14735-3;O14735 H3BUR9 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1 18059500.0 3571100.0 7640700.0 6847700.0 True False 2969527.876553991 7599538.032539798 8279522.409812509 1.0 2.5591738311474397 2.7881612007025636 21.501802145367854 -10.370766253281527 0.4066593782460429 1.458587593332151e-11 2.8071545813997076 0.9992241180084108 0.02213034315167952 1.780780049929774 0.19013207860331457 1.9756759059305002 0.05724523589830365 4.2582754109450726e-11 10.370766253281527 2.807154581385122 GSESHK(ub)MIDLSGNPVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSESHKMIDLSGNPVLR 17 1 H3BUR9;B3KY94;O14735-3;O14735 H3BUR9 CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase 1 52279200.0 7686200.0 32577000.0 12016000.0 True False 9949937.417652953 30764061.3125155 9829211.294571627 1.0 3.0918849055205713 0.9878666449834009 23.246256020857277 -6.6474706199559686 2.01732998489632 2.3600976054263434 0.9966463765477851 0.18399652914198572 0.8933891106837626 0.514718030529221 4.012045538875264 0.3595014041299912 0.9895849870930526 2.2517977458253133e-07 6.6474706199559686 -1.3634512288785583 GSETDSAQDQPVK(ub)MNSLPAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSETDSAQDQPVKMNSLPAER 21 1 P30419;B7Z8J4 P30419 NMT1 Glycylpeptide N-tetradecanoyltransferase 1 1 37875000.0 14570000.0 13067000.0 10238000.0 True False 18861152.217637263 12339809.96318383 8374789.050751026 1.0 0.6542447577324965 0.44402319402945445 24.16891447638021 -9.129030758656494 0.1284943725923005 1.5745365336775985 4.552214105598444e-16 0.999902251036321 0.0022661837161442474 0.5828807901388039 0.04370056031186127 0.31573221109433747 0.1927066218395743 7.429665158577799e-10 9.129030758656494 -1.574536533677598 GSEVGFHGAAPDISVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSEVGFHGAAPDISVK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 26336290.0 7603390.0 9951600.0 8781300.0 False True 9968117.9213335 8466860.07103297 7872695.312177536 1.0 0.8493940519014549 0.7897875380595774 23.248889704652058 -13.99999999999891 0.12798345811243042 1.7156432979886682 0.7041348336422861 0.9996548348341967 0.0016434292907082611 11.940325500739453 0.11104705509664908 2.1536090999387145 0.07612138631587986 1.0000000000025114e-14 13.99999999999891 -1.011508464346382 GSEVGFHGAAPDISVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSEVGFHGAAPDISVK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 19062100.0 5734600.0 2658500.0 10669000.0 False True 5552558.261961333 3720052.9138943544 7874468.836860695 1.0 0.6699709824531076 1.4181695113054413 22.404721195106642 -6.7867948157774505 1.5090086343244065 0.8147737620410596 1.4254501820108336 0.7907951693964761 0.14003263571827987 0.24016928957168185 1.0804166101233932 0.0730550610067579 0.17145540753397553 1.633823672322992e-07 6.7867948157774505 0.6106764199697741 GSEVGFHGAAPDISVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSEVGFHGAAPDISVK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 53212600.0 3652200.0 43768700.0 5791700.0 False True 5540654.411584774 35957833.518586025 4646967.956407707 1.0 6.489817059046845 0.8387038084691788 22.40162495364749 -6.652775835721511 1.9986229256301908 4.554498351660749 0.8624509340562981 0.2053911463015835 2.3415228949291063 0.501760955209084 3.84486897861122 0.9491190083111682 2.5939710178095106 2.2244577645557782e-07 6.652775835721511 -3.692047417604451 GSEVGFHGAAPDISVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSEVGFHGAAPDISVK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 23487890.0 7603390.0 9780300.0 6104200.0 False True 10414568.756888768 9348174.00687292 4662513.67994523 1.0 0.8976054818102309 0.44769147804235165 23.31209976617495 -6.9427233129095 0.6337232168016886 1.0049104972669214 0.31598338403124976 0.9984992710018694 0.009293397978062118 0.08654595256430204 0.04911509571358049 0.009245323770694366 0.038282854002460204 1.1409764671071081e-07 6.9427233129095 -0.6889271132356716 down GSEVGFHGAAPDISVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSEVGFHGAAPDISVK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 12290400.0 5734600.0 3432900.0 3122900.0 False True 4768573.985854916 3414406.2863227045 3775883.951341829 1.0 0.7160225040968019 0.791826647241352 22.18512647054092 -9.85213054428004 6.036317613598003 1.0000000289843543 0.7539245756688908 0.9335566735391698 0.03094691184950418 1.205520643602814e-08 2.293046090341927e-09 0.029964222124136422 0.0099880728507093 1.4056249447849132e-10 9.85213054428004 -0.24607545331546343 GSFETAK(ub)ECGQMQNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSFETAKECGQMQNK 15 1 O94888 O94888 UBXN7 UBX domain-containing protein 7 1 7680700.0 2764800.0 2444800.0 2471100.0 True False 2677032.937375006 3421021.3894635737 1823844.7785890393 1.0 1.2779153150121842 0.6812933651751892 21.352203458880098 -6.780056086593789 1.535814620186855 1.157351946637239 0.6765723985380655 0.767532538126001 0.11752838765410874 0.25048853805359395 1.16704188262967 0.06027465615939866 0.1422065515148044 1.659372595327999e-07 6.780056086593789 -0.48077954809917356 GSFETAK(ub)ECGQMQNK ddPTM_RPMI8226_Bortezomib_8h_R1 2 GSFETAKECGQMQNK 15 1 O94888 O94888 UBXN7 UBX domain-containing protein 7 1 73581200.0 11795700.0 31768700.0 30016800.0 True False 17894939.281181347 26099327.275014002 24083966.323169164 1.0 1.4584753189110031 1.345853480961308 24.09304831280589 -10.086841356208637 4.983434068226804 0.9999886828996155 1.4021643999380433 0.9444507064748505 0.045977672818403106 5.7813023908631296e-06 1.0593815262289368e-06 0.04451894263622092 0.014839230092651902 8.187638204293788e-11 10.086841356208637 0.4021757170384278 GSFETAK(ub)ECGQMQNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSFETAKECGQMQNK 15 1 O94888 O94888 UBXN7 UBX domain-containing protein 7 1 9069660.0 2764800.0 1956000.0 4348860.0 True False 2299053.701407541 1945462.6397644002 5258186.519143242 1.0 0.8462014778399204 2.287109046615154 21.132608734314374 -6.880493588524575 1.0770103644923468 0.9040350927556963 2.3902099913341877 0.9740827646803318 0.10400778208193076 0.12719523470762584 0.26963409450635234 0.07435567609502461 0.1800434931557653 1.3167593518539584e-07 6.880493588524575 1.4861748985784913 up GSFETAK(ub)ECGQMQNK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GSFETAKECGQMQNK 15 1 O94888 O94888 UBXN7 UBX domain-containing protein 7 1 73505000.0 11795700.0 23593600.0 38115700.0 True False 15269766.17800848 22280595.419558786 31179033.700108528 1.0 1.4591314077649273 2.041880231605156 23.86417463489834 -6.967884344235935 0.30451117748637024 0.9042001233087985 2.615189468107158 0.9999608588008062 0.0026673179949804958 0.07699535826370059 0.01147446384197761 0.009458206531054895 0.052019822799637565 1.0767519222825554e-07 6.967884344235935 1.7109893447983593 GSFGK(ub)DQAHK(ub)GSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSFGKDQAHKGSVR 14 2 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 2 5579170.0 1861500.0 3253500.0 464170.0 True False 2440444.5267916457 2768090.482043672 416142.14103304147 1.0 1.1342566699038101 0.17051899211990154 21.218712527844474 -6.871652592978665 1.1252605458049911 1.0767523211225802 0.1122625047665867 0.9663076789124532 0.07823186512639807 0.13528305749832023 0.3191365490725306 0.05389779116759042 0.1279897430719198 1.3438395145198594e-07 6.871652592978665 -0.9644898163559935 down GSFGK(ub)DQAHK(ub)GSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSFGKDQAHKGSVR 14 2 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 2 7347140.0 4018500.0 2641600.0 687040.0 True False 3890934.917115689 3696404.6557620135 507083.6132418007 1.0 0.9500042366429817 0.1303243626644099 21.891685418167526 -6.919380347980104 0.8293404030183292 1.0184951086996643 2.3487934042603408e-05 0.9940060024479158 0.03086831215057317 0.09853897767903955 0.10752543936002261 0.02650878134211234 0.07893842169167954 1.2039810516654327e-07 6.919380347980104 -1.0184716207656217 down GSFLNAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSFLNAKR 8 1 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4 A3QJZ7 LOC101929983;PRAMEF25 1 15488180.0 457880.0 4926300.0 10104000.0 True False 592734.6861641558 4652147.074434266 8265175.67579493 1.0 7.848616224132816 13.944140386456004 19.177026959296477 -7.707685939322183 0.3445109110591081 9.181753964692395e-16 17.31064886547058 0.9987516635150191 0.18681351509984884 0.13840208797485806 0.0587152115665058 0.5810305075881702 1.4161739342096937 1.9602617271530844e-08 7.707685939322183 17.31064886547058 GSFMLGLETHDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSFMLGLETHDR 12 0 Q92905 Q92905 COPS5 COP9 signalosome complex subunit 5 0 11586580.0 3715600.0 3094680.0 4776300.0 False True 4871187.581921583 2632965.8069681562 4282094.29350478 1.0 0.5405182540577724 0.8790657763615792 22.215842109533394 -9.8654547069128 5.761369065804496 1.000000084367504 0.7097920152090781 0.494887386607905 0.13821144722342432 1.4977906452228316e-07 2.9420038843512172e-08 0.13382269622494108 0.044607552778986724 1.363155163865456e-10 9.8654547069128 -0.290208069158426 GSFMLGLETHDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSFMLGLETHDR 12 0 Q92905 Q92905 COPS5 COP9 signalosome complex subunit 5 0 12888700.0 3715600.0 5262300.0 3910800.0 False True 5089357.73031449 5029794.185900981 2987149.585454241 1.0 0.9882964516212482 0.5869403849647751 22.279052171056286 -6.913132306509577 0.8741212425666003 1.0112298837171338 0.5314383731437751 0.9920511292877114 0.01711973568308047 0.10238332342514746 0.1277974343126904 0.014236932867972507 0.04020859086092339 1.2214274992596144e-07 6.913132306509577 -0.4797915105733588 GSFMLGLETHDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSFMLGLETHDR 12 0 Q92905 Q92905 COPS5 COP9 signalosome complex subunit 5 0 15656700.0 5835000.0 9821700.0 0.0 False True 7553522.525045529 9275113.761031808 0.0 1.0 1.227918991474233 0.0 22.848718160023044 -6.90566888134561 1.2871214272093423 1.118926624621042 1.6183462684915046e-22 0.9506978514677862 0.11841560178511548 0.13084933095318182 0.4347742616838558 0.07528721054173836 0.14916614469942927 1.242599340144278e-07 6.90566888134561 -1.118926624621042 down GSFSEQGINEFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSFSEQGINEFLR 13 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 61271400.0 7181400.0 25880000.0 28210000.0 False True 9414884.944776522 22018804.879449874 25291099.80942776 1.0 2.33872267251297 2.6862887818357812 23.166512033721343 -10.18919912761229 0.3100761518302176 1.1730900882789274e-11 2.7924262709634182 0.9989527851015185 0.023525707444617905 1.6313870363679899 0.14325172767802594 1.5010614580398178 0.11903211258586471 6.468459635202632e-11 10.18919912761229 2.792426270951687 GSFSEQGINEFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSFSEQGINEFLR 13 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 54516400.0 19005000.0 7692400.0 27819000.0 False True 18401696.677811034 10764015.435336068 20532369.347888995 1.0 0.5849469004842056 1.1157867509384147 24.13333545635332 -6.698112864230374 1.8373620231488283 0.741788642485006 1.1141620671535797 0.4086223392607766 0.1752614873952156 0.39952198805929523 2.62076277591569 0.07613211686599373 0.19626639387967157 2.0039511738706686e-07 6.698112864230374 0.3723734246685737 GSFSEQGINEFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSFSEQGINEFLR 13 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 60252400.0 7181400.0 28620000.0 24451000.0 False True 9836557.650037806 27355473.766316246 18676177.38415202 1.0 2.781000705690075 1.8986497155415176 23.229722095244234 -10.106921251539186 5.6443359247900355 0.999987804356529 2.3398252106159947 0.754561635663528 0.3602182833179465 5.528320639129817e-05 8.748545706501874e-06 0.3487830196250263 0.11625995102405069 7.81769546125239e-11 10.106921251539186 1.3398374062594658 GSFVNGVFEVHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSFVNGVFEVHK 12 0 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 0 9629600.0 2049500.0 2955000.0 4625100.0 False True 2686914.3473862335 2514125.518499784 4146539.0190919703 1.0 0.9356924685542976 1.543234537091078 21.35751890162774 -6.8807366952238445 1.07572553337324 0.9597460820987738 1.5868960553230245 0.9742729692817689 0.0437093593516609 0.12697752551146607 0.2683834561629187 0.031280033854966575 0.07578391693188913 1.3160224706492437e-07 6.8807366952238445 0.6271499732242507 GSFVNGVFEVHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSFVNGVFEVHK 12 0 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 0 5925300.0 1170700.0 1350300.0 3404300.0 False True 1133536.7693087826 1889481.831721476 2512611.703189137 1.0 1.6668906407629456 2.2166124392429705 20.11239975884934 -6.973338536749021 0.15939335721480516 0.4389814083744301 3.4590995078420197 0.9999980960313435 0.0006863750389402316 0.07523357288552865 0.004917277758954963 0.025592060043111826 0.06611528282105196 1.0633138316709653e-07 6.973338536749021 3.02011809946759 GSFVNGVFEVHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSFVNGVFEVHK 12 0 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 0 6836000.0 2049500.0 2365400.0 2421100.0 False True 2807255.5356549555 2260888.8066682173 1849286.0441196843 1.0 0.8053733541363322 0.6587523011823827 21.42072896315063 -6.9742533364813015 0.11860781302389486 1.2694867312309797 0.19087527293645845 0.9999994729089975 0.00010131193030887065 0.07494507660958677 0.0035282049389673076 0.010497482267175305 0.02130274934162095 1.0610764201954722e-07 6.9742533364813015 -1.0786114582945212 GSGAIQTIK(ub)QYNYLHEFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSGAIQTIKQYNYLHEFR 18 1 F8WD24;A0A087WWK3;H7C0S3;Q16667-2;Q16667 F8WD24 CDKN3 Cyclin-dependent kinase inhibitor 3 1 10605300.0 2726500.0 4592200.0 3286600.0 True False 3529507.9973498974 4336640.03313177 2688472.523363775 1.0 1.2286811749365354 0.7617131128141353 21.751035659547608 -6.7735404017835394 1.5608771598989746 1.1305709102768355 0.7587260694579888 0.7439290990895089 0.09647666738148489 0.2607412214866166 1.2541477862383337 0.048705479777582994 0.1155680223690797 1.6844557170212803e-07 6.7735404017835394 -0.3718448408188467 GSGDPSSSSSSGNPLVYLDVDANGKPLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSGDPSSSSSSGNPLVYLDVDANGKPLGR 29 1 P30405;R4GN99;P30405-2 P30405 PPIF Peptidyl-prolyl cis-trans isomerase F, mitochondrial;Peptidyl-prolyl cis-trans isomerase 0 9911800.0 3528500.0 0.0 6383300.0 False True 3416489.6989032472 0.0 4711322.235104783 1.0 0.0 1.3789950066634769 21.70408334625714 -6.712187572608396 1.787167377687103 0.3866012527152565 1.3759996014225826 0.47554766182920616 0.4212542195750547 0.37072036504216327 2.3094125933744265 0.18747152014311763 0.47504935036740065 1.9400477863098251e-07 6.712187572608396 0.9893983487073261 GSGDPSSSSSSGNPLVYLDVDANGKPLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSGDPSSSSSSGNPLVYLDVDANGKPLGR 29 1 P30405;R4GN99;P30405-2 P30405 PPIF Peptidyl-prolyl cis-trans isomerase F, mitochondrial;Peptidyl-prolyl cis-trans isomerase 0 58840200.0 9037200.0 31758000.0 18045000.0 False True 13710093.107818287 26090536.77361344 14478397.84059552 1.0 1.903016746015759 1.056039351938398 23.708735032975035 -10.212399981314842 3.9080727148998418 0.9996269541921396 1.4795280483490352 0.2994200247387273 0.3457770740039779 22333482.05023284 16786739.03595797 68326.38403612227 0.11836869015656576 6.131969960979712e-11 10.212399981314842 0.4799010941568955 GSGDPSSSSSSGNPLVYLDVDANGKPLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSGDPSSSSSSGNPLVYLDVDANGKPLGR 29 1 P30405;R4GN99;P30405-2 P30405 PPIF Peptidyl-prolyl cis-trans isomerase F, mitochondrial;Peptidyl-prolyl cis-trans isomerase 0 5713700.0 3528500.0 2185200.0 0.0 False True 2934104.0890540006 2173427.89387176 0.0 1.0 0.7407466906099115 0.0 21.484488621691415 -7.3508846205604215 0.7876627969819011 0.9894647104922232 8.541381983408899e-23 0.9878148879038331 0.046773854184383935 0.10896699436142729 0.13792069141367896 0.0401752086388243 0.07153505476075493 4.457746620575337e-08 7.3508846205604215 -0.9894647104922232 down GSGDPSSSSSSGNPLVYLDVDANGKPLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSGDPSSSSSSGNPLVYLDVDANGKPLGR 29 1 P30405;R4GN99;P30405-2 P30405 PPIF Peptidyl-prolyl cis-trans isomerase F, mitochondrial;Peptidyl-prolyl cis-trans isomerase 0 28680400.0 9037200.0 11694000.0 7949200.0 False True 11698833.549844291 11043218.620147849 6502527.1656798385 1.0 0.943958948821426 0.5558269666779203 23.479861355067484 -6.9328803027459145 0.7227625320872948 1.005318013872234 0.4699689134428897 0.9970745730831909 0.010682534983549975 0.09116983637990095 0.07055521568690105 0.009904682242850245 0.03457994435954119 1.1671312494127277e-07 6.9328803027459145 -0.5353491004293442 GSGGFGSTGK(ub)N ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSGGFGSTGKN 11 1 P33316-2;H0YNW5;P33316;A0A0C4DGL3 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 20219700.0 10625000.0 7754200.0 1840500.0 True False 13929477.892646354 6597303.58563486 1650062.7153226433 1.0 0.4736217420695794 0.11845833189438809 23.731637847792747 -8.261891788201416 0.3647815128205252 1.0987878340152235 7.050050329658836e-23 0.9978494316315673 0.016794118844881946 0.10737058066337282 0.09299151760054485 0.07459044447064414 0.08618717439641617 5.4715227813355755e-09 8.261891788201416 -1.0987878340152235 GSGGFGSTGK(ub)N ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSGGFGSTGKN 11 1 P33316-2;H0YNW5;P33316;A0A0C4DGL3 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 17728600.0 8638300.0 7735000.0 1355300.0 True False 8364081.894866359 10823625.837492133 1000306.2718715263 1.0 1.2940602415831644 0.11959546599914168 22.99577575711718 -6.8403694739324745 1.2805293425618214 1.1564255680188054 0.0806396376580648 0.9251294814878582 0.13653699901975871 0.16834939056913784 0.536050436771443 0.08360141054085682 0.19263690446251844 1.4442105927763918e-07 6.8403694739324745 -1.0757859303607407 down GSGIQWDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSGIQWDLR 9 0 O75306-2;O75306 O75306-2 NDUFS2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial 0 10832500.0 3231200.0 2780700.0 4820600.0 False True 4236134.490985315 2365830.3990837047 4321810.554460384 1.0 0.5584880282055016 1.0202250574568374 22.014316962808685 -11.00253701948973 11.828358195699622 1.2257130916160661 0.789356542830701 0.21721420039943695 0.18850335283572056 0.060802366078993024 1.3041246382430672e-05 0.009890622178918446 0.060839195519750526 9.941753263140849e-12 11.00253701948973 -0.4363565487853651 GSGIQWDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSGIQWDLR 9 0 O75306-2;O75306 O75306-2 NDUFS2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial 0 4001300.0 1178200.0 1147100.0 1676000.0 False True 979725.5031099404 1140920.344618476 2026443.8510515576 1.0 1.1645306169910399 2.068379198682714 19.90201806981353 -6.937729880917774 0.6803611073913465 0.9893460867229951 2.296654254708184 0.9978511086907668 0.021772839471585245 0.08881779821246985 0.05944268665612669 0.020845963433707197 0.07860221056513934 1.154170896801839e-07 6.937729880917774 1.307308167985189 up GSGLGTICLWSWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSGLGTICLWSWR 13 0 Q9UFC0;H7C5N7 Q9UFC0 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 0 3470700.0 637700.0 1498400.0 1334600.0 False True 836030.875495585 1274844.560717455 1196508.394387179 1.0 1.5248773676710787 1.4311772799992692 19.673196697965253 -10.084240519421037 4.723737263102188 0.9999777867211698 1.4780273238421124 0.9719909708058385 0.03825290063676395 9.09531872582086e-06 1.7632529590368869e-06 0.03703995854560763 0.012346070588491489 8.236818201449317e-11 10.084240519421037 0.47804953712094267 GSGLGTICLWSWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSGLGTICLWSWR 13 0 Q9UFC0;H7C5N7 Q9UFC0 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 0 5082870.0 2081400.0 873670.0 2127800.0 False True 2015327.096300758 1222530.9871288629 1570465.3473682802 1.0 0.6066166576000912 0.7792607712420254 20.942582582724167 -9.99905006823467 4.642356330059898 1.0000065849004316 0.6929387144128368 0.8083481059288282 0.070481664318987 48570958.980990894 3.824747325275538 3595.718831759157 0.024127748388864594 1.0021896926051216e-10 9.99905006823467 -0.30706787048759476 GSGLGTICLWSWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSGLGTICLWSWR 13 0 Q9UFC0;H7C5N7 Q9UFC0 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 0 6337600.0 637700.0 1768800.0 3931100.0 False True 873474.9231945185 1690648.567360594 3002655.143545869 1.0 1.93554333669645 3.4375974213024914 19.736406759488144 -6.964102907427754 0.3731339139990471 0.8885177740603507 4.537165230625152 0.9998934341975193 0.010365016069332381 0.07826677977463108 0.01594185390071207 0.019708925235575336 0.12735756888398286 1.0861682221849779e-07 6.964102907427754 3.648647456564801 GSGNLEAIHIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSGNLEAIHIIK 12 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 26088200.0 4539400.0 9886100.0 11662700.0 False True 5951197.359612127 8411132.415715978 10455955.680518012 1.0 1.413351281676227 1.7569499125465882 22.504748532028298 -6.9732496642590185 0.1628104644067161 0.6653590450709251 2.5140821980538766 0.9999979073372555 0.000447629592050694 0.07526162607695831 0.005040239363860972 0.01548392013610205 0.040812712310701736 1.063531446725909e-07 6.9732496642590185 1.8487231529829513 GSGNLEAIHIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSGNLEAIHIIK 12 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 20559600.0 7600400.0 2335900.0 10623300.0 False True 7359129.462248628 3268637.05155758 7840739.03783132 1.0 0.4441608302076028 1.065443824307384 22.81110368414212 -6.67082139556175 1.9342961565985006 0.6454618991724819 1.0629501528804943 0.2827358900529614 0.23606366229741604 0.45924934966771447 3.313422443807769 0.09821850376660805 0.26215024427187145 2.1339223123599664e-07 6.67082139556175 0.41748825370801246 GSGNLEAIHIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSGNLEAIHIIK 12 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 32536300.0 4539400.0 8969700.0 19027200.0 False True 6217738.852672405 8573388.99516865 14533367.237484653 1.0 1.3788596141318767 2.3374039312117723 22.56795859355119 -6.955204834282208 0.49844093009260904 0.9805411819869537 2.776955696919689 0.9995489612630927 0.011953182376878703 0.08146064460246324 0.02781563391875461 0.014059441507425234 0.07906738720195794 1.1086517981243494e-07 6.955204834282208 1.7964145149327355 up GSGNLEAIHIIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSGNLEAIHIIK 12 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 8919600.0 7600400.0 561700.0 757500.0 False True 6320069.354809711 558674.0106112793 915889.7477157249 1.0 0.08839681643463551 0.14491767357247634 22.591508959576398 -10.076288401804979 4.862602439451303 1.000027494121803 0.11665724500012829 0.9969388206470958 0.023074543337946573 258413455.78869912 989814153.4644442 142070.4568447121 0.008444243878359294 8.389027116357203e-11 10.076288401804979 -0.8833702491216747 GSGNLEAIHIIKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSGNLEAIHIIKK 13 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 9326100.0 2508200.0 4020900.0 2797000.0 True False 3435549.3215563633 3843243.342661804 2136406.2060231944 1.0 1.1186692382925094 0.6218528701125925 21.712109364182343 -6.843669605626714 1.265244263869163 1.0631310603415793 0.604288615356811 0.930581162280946 0.05581572450976774 0.16455610073263863 0.5101189559927523 0.03456889166231016 0.07973603201097797 1.4332778667492145e-07 6.843669605626714 -0.45884244498476834 GSGPSGGSGGGANGTSFSYTFHGDPHAMFAEFFGGR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GSGPSGGSGGGANGTSFSYTFHGDPHAMFAEFFGGR 36 0 P25685;M0QXK0 P25685 DNAJB1 DnaJ homolog subfamily B member 1 0 458381000.0 117527000.0 115263000.0 225591000.0 False True 178297051.3746028 94693417.09607051 181002839.96995214 1.0 0.5310991761558596 1.0151757338356902 27.4097076033831 -10.929546779391652 11.659225131800891 1.0342241632540066 0.7731374549958008 0.22651143451010214 0.19762342712642242 0.10981642326530101 0.0006635868056349843 0.11952214407738063 0.06378268684008907 1.1761242933624488e-11 10.929546779391652 -0.2610867082582058 GSGPSGGSGGGANGTSFSYTFHGDPHAMFAEFFGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSGPSGGSGGGANGTSFSYTFHGDPHAMFAEFFGGR 36 0 P25685;M0QXK0 P25685 DNAJB1 DnaJ homolog subfamily B member 1 0 237723500.0 79901000.0 62635000.0 95187500.0 False True 103433419.58417527 59149307.189409904 77864351.70622817 1.0 0.5718587611934607 0.7527968428314534 26.624127158276377 -10.204480083735536 5.433786271186866 1.0000160623877368 0.6623278020124159 0.8228130305073167 0.07386766250866623 1.4374268888187501e-05 2.104544419745862e-06 0.07152545575658568 0.023840685559923566 6.244819876769247e-11 10.204480083735536 -0.33768826037532085 GSGSQSSVPSVDQFTGVGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSGSQSSVPSVDQFTGVGIR 20 0 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 0 5766730.0 995230.0 2339300.0 2432200.0 False True 1304756.16782103 1990285.5585199813 2180539.2753098276 1.0 1.5254080475770426 1.671223581147253 20.315348791182036 -11.541490129130862 0.22606558433573415 3.126770413593256e-15 1.7556070782539073 0.9993296165100061 0.007463619965398874 4.104022342195302 0.1306066239492081 2.076010970456744 0.07706171448958771 2.8741529181036194e-12 11.541490129130862 1.7556070782539042 GSGSQSSVPSVDQFTGVGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSGSQSSVPSVDQFTGVGIR 20 0 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 0 4488430.0 995230.0 1677200.0 1816000.0 False True 1363193.4260794737 1603095.7582412858 1387098.2016940035 1.0 1.1759855406959876 1.0175358647989374 20.378558852704927 -10.786709378741334 2.8230345585395114 0.9758282417292742 1.0967607025704265 0.33209825167563944 0.06468681033635221 24234620.30099863 19871729.853440333 4034620.2623109333 0.023672946696981632 1.634145119610995e-11 10.786709378741334 0.12093246084115228 GSGTAEVELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSGTAEVELK 10 0 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 132958000.0 28956000.0 46505000.0 57497000.0 False True 37961596.41030291 39566635.275070205 51547761.99016911 1.0 1.042280594509763 1.3578923666176186 25.178037327929868 -6.9314074346924315 0.7351393248924515 0.9954425671872041 1.425072830646879 0.9968078903214608 0.009021839064369836 0.09191322249811455 0.07414571417381605 0.008289297858812014 0.02833954151510765 1.1710961825732772e-07 6.9314074346924315 0.4296302634596748 GSGTAEVELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSGTAEVELK 10 0 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 120125000.0 25432000.0 11455000.0 83238000.0 False True 24624675.080772985 16029041.23703584 61435470.713526234 1.0 0.6509341213420258 2.4948743693879325 24.553601352741968 -6.857714851263938 1.1971958646245504 0.8116392835585651 2.5803612930597746 0.9508051019902083 0.17738719114620208 0.1491750106121577 0.40758048722910895 0.11566541130192304 0.2693463488495114 1.3876666429228133e-07 6.857714851263938 1.7687220095012095 up GSGTAEVELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSGTAEVELK 10 0 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 136822000.0 6831000.0 119090000.0 10901000.0 False True 10363126.41299372 97837459.045583 8746412.571921973 1.0 9.440921122308255 0.8439936196238382 23.304955974193664 -6.650404069960708 2.0071026951865374 6.475819779399943 0.8803173545297701 0.19552430422556333 3.602380452441949 0.5076690278930587 3.9205186710527893 1.4553718830606186 3.990127622005505 2.2366391888584527e-07 6.650404069960708 -5.5955024248701735 GSGTAEVELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSGTAEVELK 10 0 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 121264000.0 28956000.0 43489000.0 48819000.0 False True 39661815.70647716 41567512.18110854 37288957.65886534 1.0 1.0480486442863524 0.9401727327570556 25.24124738945276 -6.785629840375362 1.5138379065134477 1.027007674190219 0.9391609093179416 0.7868303369996519 0.020373833559987977 0.24192667954529354 1.095321241730172 0.01059639603176319 0.02488907689480948 1.6382122141945617e-07 6.785629840375362 -0.08784676487227738 GSGTAEVELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSGTAEVELK 10 0 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 60610000.0 25432000.0 21601000.0 13577000.0 False True 21147834.82863013 21484631.125537205 16415887.927044764 1.0 1.015925805153874 0.7762443796289153 24.334006628176244 -6.891013477788007 1.0163868936430418 1.012567237485139 0.7552169804640563 0.9815384248089473 0.014868144788931783 0.11832394391158925 0.21708443765153523 0.011131208634880325 0.02785296775930748 1.2852467732928288e-07 6.891013477788007 -0.25735025702108283 GSGTAEVELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSGTAEVELK 10 0 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 29439000.0 6831000.0 22608000.0 0.0 False True 8842864.159140714 21349844.925970774 0.0 1.0 2.414358576785533 0.0 23.076082296286113 -6.7496930663850625 1.6627627643010072 1.8336192357722851 1.3927914920981036e-08 0.6399497187272387 0.5943322553515504 0.30219081724151986 1.6457855152251404 0.28296964421560017 0.6840414959667037 1.7795366368062324e-07 6.7496930663850625 -1.8336192218443703 GSGTAEVELKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSGTAEVELKK 11 1 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 110931200.0 19181800.0 44241500.0 47507900.0 False True 25147525.556815457 37640840.65201627 42592238.235955775 1.0 1.4968009702177194 1.6936949975347562 24.583913114240836 -11.278516173385642 0.170942252749269 4.361816427811027e-20 1.897799547393511 0.9995174734609527 0.006411767044128106 3.7044616346538235 0.10210853642953759 1.565243073211572 0.1547864217057126 5.266036034963207e-12 11.278516173385642 1.897799547393511 GSGTAEVELKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSGTAEVELKK 11 1 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 57251440.0 18532300.0 7495340.0 31223800.0 False True 17944002.280568153 10488268.349681748 23045350.086078454 1.0 0.5844999452011697 1.2842926413933102 24.096998373105702 -6.745847999514698 1.665026113520592 0.7544632917185702 1.285267488299471 0.6309305143275755 0.17457321364647804 0.3073741890947355 1.6751898024265295 0.08286849218755209 0.20208171241751738 1.7953618828626195e-07 6.745847999514698 0.5308041965809008 GSGTAEVELKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSGTAEVELKK 11 1 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 232737840.0 7394840.0 215082000.0 10261000.0 False True 11218512.915219208 176698936.65666395 8232908.852443931 1.0 15.750655901723965 0.7338681084259429 23.41937811448746 -6.61225507476742 2.1451699040384997 9.999999999999988 0.788439743388049 0.22546410877417322 6.175585311251801 0.5158327223159027 4.500864492665312 2.433889229404132 7.026049886150918 2.4419958706696877e-07 6.61225507476742 -9.21156025661194 GSGTAEVELKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSGTAEVELKK 11 1 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 98566600.0 19181800.0 31934600.0 47450200.0 False True 26273829.828653943 30523623.778399825 36243440.02754449 1.0 1.1617500751683756 1.3794502082074767 24.647123175763728 -6.966996001233501 0.32196179044054096 0.9708640956419146 1.5773783112780926 0.9999485727495488 0.001114905440153487 0.07729001451236647 0.012505475992793471 0.003274084286720414 0.019116487597505408 1.0789566566776499e-07 6.966996001233501 0.606514215636178 GSGTAEVELKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSGTAEVELKK 11 1 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 29732920.0 18532300.0 6519600.0 4681020.0 False True 15410428.570093673 6484477.620760724 5659799.639408925 1.0 0.42078502822075037 0.3672707487443045 23.87740364853998 -13.999999999999998 0.33698468912752194 7.577354475175178 0.35855119389913476 0.9997291496567777 0.004714951004531992 19.43069653718625 0.18602818010316127 90.9030424996008 0.016714192962509263 1.0000000000000041e-14 13.999999999999998 -7.218803281276044 GSGTAEVELKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSGTAEVELKK 11 1 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 35601940.0 7394840.0 18584600.0 9622500.0 False True 9572766.154088723 17550350.67282363 7871303.735187716 1.0 1.8333625192889016 0.8222601083622755 23.19050443657991 -6.687799141833822 1.8742771337831496 1.523567822755244 0.8258668615806413 0.35995748866241717 0.35261852519286485 0.42151651299609794 2.8691768432458544 0.150603321149773 0.3932670670607345 2.0521110464200225e-07 6.687799141833822 -0.6977009611746028 GSGVVK(ub)YSCLCSAVRPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSGVVKYSCLCSAVRPK 17 2 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 10181400.0 3317200.0 4918700.0 1945500.0 True False 4348881.323810497 4184849.132942429 1744198.3225537657 1.0 0.9622817504883432 0.4010682731221316 22.052212909101975 -6.920524657075105 0.8208306844787668 1.0121503438594828 0.3094677174836186 0.9943252838397292 0.020631729790797575 0.09786420845116355 0.10402348407309464 0.01782585752961802 0.05366731544359815 1.2008128949108757e-07 6.920524657075105 -0.7026826263758641 down GSGVVK(ub)YSCLCSAVRPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSGVVKYSCLCSAVRPK 17 2 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 30529000.0 12413000.0 6484000.0 11632000.0 True False 18831428.51185639 5326879.540276774 9332930.101513285 1.0 0.28287177135409225 0.4956039365594178 24.166639108072392 -10.198476775928917 5.082404395353581 1.0000515473298917 0.38923785395671806 0.9166004992661041 0.08684754277342242 5.0730877026634574e-05 8.00046067858129e-06 0.0840968377983065 0.028029923901468582 6.33174220050121e-11 10.198476775928917 -0.6108136933731736 GSGVVK(ub)YSCLCSAVRPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSGVVKYSCLCSAVRPK 17 2 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 13741500.0 3317200.0 7065200.0 3359100.0 True False 4543658.483959317 6753036.102507941 2565749.76283608 1.0 1.4862552118185137 0.5646880750157747 22.115422970624866 -6.7633191006146625 1.5997585339270597 1.2812698755084926 0.560729923981245 0.7044732316342158 0.20463072243246053 0.2773650603784805 1.3996873545797521 0.10088593659876881 0.24167813158292178 1.7245702874416333e-07 6.7633191006146625 -0.7205399515272476 GSGVVK(ub)YSCLCSAVRPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSGVVKYSCLCSAVRPK 17 2 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 32719000.0 12413000.0 10225000.0 10081000.0 True False 16068873.196810663 9655969.761502631 8246361.439795005 1.0 0.600911441843921 0.5131885315662169 23.93776543016484 -13.99999999999997 0.21289839134665395 3.3360123515360645 0.46294855959194675 0.9994918359526092 0.0047757929259429665 12.816091505432624 0.14622614255344968 12.540975385264801 0.0509273056645366 1.0000000000000696e-14 13.99999999999997 -2.8730637919441175 GSIFVVFDSIESAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSIFVVFDSIESAK 14 0 P05455;E7ERC4;E9PGX9 P05455 SSB Lupus La protein 0 5691800.0 1867800.0 2639800.0 1184200.0 False True 2448703.887800932 2245952.129859809 1061670.3436485075 1.0 0.917200377329737 0.43356420061142825 21.223586894295934 -6.936405682092211 0.6921926496189513 1.005910956965335 0.3158676387748423 0.9976542178504177 0.012098726470120853 0.08944528877879235 0.06236735214822631 0.011478177654040102 0.042326544101794296 1.1576954273071097e-07 6.936405682092211 -0.6900433181904928 down GSIFVVFDSIESAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSIFVVFDSIESAK 14 0 P05455;E7ERC4;E9PGX9 P05455 SSB Lupus La protein 0 19901800.0 8399200.0 4921200.0 6581400.0 False True 8132571.993489629 6886260.82371897 4857533.902232168 1.0 0.8467506748457476 0.5972936859484025 22.95528025808652 -6.963862953947627 0.37705749237491476 1.0177124048409938 0.41755155427873103 0.999887753311694 0.0017582864454515328 0.0783489410374547 0.016233565849931852 0.003256966472660859 0.021109149512721526 1.0867685103990132e-07 6.963862953947627 -0.6001608505622628 GSIFVVFDSIESAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSIFVVFDSIESAK 14 0 P05455;E7ERC4;E9PGX9 P05455 SSB Lupus La protein 0 65487000.0 12601000.0 29316000.0 23570000.0 False True 19116638.256497398 24084330.75304652 18911379.168902002 1.0 1.259862243031182 0.9892628042210491 24.18832550567355 -6.655353776383029 1.9892616321909526 1.1679035972553673 0.9903943386227372 0.2161166829253155 0.11076695386706209 0.49553912318031884 3.764469820390217 0.045063361741992984 0.12274636487500104 2.211292656231634e-07 6.655353776383029 -0.17750925863263012 GSIFVVFDSIESAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSIFVVFDSIESAK 14 0 P05455;E7ERC4;E9PGX9 P05455 SSB Lupus La protein 0 6618000.0 1867800.0 1887800.0 2862400.0 False True 2558376.1353970873 1804390.753880218 2186360.072978477 1.0 0.7052875177012067 0.8545889881978322 21.286796955818826 -10.077891823942615 4.568981927216548 1.000012902980635 0.7799382529833817 0.7433709085082828 0.06095207012369183 84670073.13748962 0.3432924555886953 12000.86775855863 0.02086551482891744 8.358111799795771e-11 10.077891823942615 -0.22007464999725335 GSIFVVFDSIESAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSIFVVFDSIESAK 14 0 P05455;E7ERC4;E9PGX9 P05455 SSB Lupus La protein 0 15931200.0 8399200.0 4281600.0 3250400.0 False True 6984306.947649811 4258534.170968937 3930043.6118484414 1.0 0.6097289541952211 0.5626962905991529 22.735685533520797 -13.999999999999998 0.29850217636840676 4.529456341497093 0.5509433405914144 0.9996464867022475 0.003685252659161809 16.491549182977526 0.17347130471865602 35.91924475640202 0.017107548629541575 1.0000000000000041e-14 13.999999999999998 -3.978513000905679 GSIFVVFDSIESAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSIFVVFDSIESAK 14 0 P05455;E7ERC4;E9PGX9 P05455 SSB Lupus La protein 0 46534000.0 12601000.0 19137000.0 14796000.0 False True 16312242.902844682 18072009.12722503 12103279.819780441 1.0 1.1078800895046421 0.7419752079384349 23.959451827766 -6.827740444869524 1.3378790576225525 1.0577425852087 0.7325696589568357 0.9012876473564319 0.04823209743110803 0.1836242998875562 0.6435741488744002 0.028311408388431266 0.06516477833129847 1.4868239738445382e-07 6.827740444869524 -0.3251729262518642 GSIINISSIVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSIINISSIVGK 12 0 Q92506 Q92506 HSD17B8 Estradiol 17-beta-dehydrogenase 8 0 5975400.0 1754500.0 1714500.0 2506400.0 False True 2300166.49060217 1458703.2830686572 2247061.771086484 1.0 0.6341729127124086 0.976912662743042 21.133306859395127 -10.526196155409007 8.892499740243771 1.0000118993569183 0.8055427883824441 0.30030698501636754 0.13992291702401782 3.3011554723945414e-05 1.758738892518937e-06 0.1354880654540468 0.045159927282231935 2.977171442997915e-11 10.526196155409007 -0.19446911097447417 GSIINISSIVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSIINISSIVGK 12 0 Q92506 Q92506 HSD17B8 Estradiol 17-beta-dehydrogenase 8 0 5005800.0 1442400.0 1191100.0 2372300.0 False True 1396611.8015298415 1666712.4415044447 1750923.4625255072 1.0 1.1933970768961972 1.2536937326518038 20.41349963814897 -13.999999999998494 0.16317734016034668 0.04087215661131061 1.3109383161365498 0.9995283716001092 0.002350146224496744 12.032490803983807 0.12775632468535136 3.652048416928342 0.0523898928684797 1.0000000000034685e-14 13.999999999998494 1.2700661595252392 GSIINISSIVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSIINISSIVGK 12 0 Q92506 Q92506 HSD17B8 Estradiol 17-beta-dehydrogenase 8 0 5861800.0 1754500.0 1942400.0 2164900.0 False True 2403186.0635797125 1856578.3453421614 1653595.2075150602 1.0 0.772548731651955 0.6880845526591958 21.196516920918018 -13.999999999914296 0.1375875427279941 2.08440520934319 0.5804540880539591 0.9996127233211557 0.0025922243058833848 11.932304097019353 0.11603259853418903 3.4790015007015374 0.09607269629338228 1.0000000001973405e-14 13.999999999914296 -1.503951121289231 GSILQK(ub)HPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSILQKHPR 9 1 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 4281860.0 867760.0 1648200.0 1765900.0 True False 1137641.7633997938 1402294.9846332804 1583181.6077089142 1.0 1.232633180099315 1.3916345713062113 20.117614902424926 GSILQK(ub)HPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSILQKHPR 9 1 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 9840910.0 620410.0 1511900.0 7708600.0 True False 941207.328046469 1242089.6324713826 6184991.831200601 1.0 1.3196769675066304 6.571338372426311 19.8441530275693 -6.919354941319347 0.8295100250326901 0.8814100280085702 7.40574118296625 0.993999606973544 0.19786493479583028 0.09855260719400831 0.10759616503873888 0.1699012231889463 0.5058286550226347 1.204051487819187e-07 6.919354941319347 6.52433115495768 up GSILQK(ub)HPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSILQKHPR 9 1 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 4406860.0 867760.0 1261500.0 2277600.0 True False 1188594.3223322488 1205762.7587773572 1739677.7886444181 1.0 1.0144443197502582 1.463643024333852 20.180824963947817 -6.9137476583993855 0.8698337931518569 0.9876854060462038 1.5265980847182141 0.992260349365885 0.018935768652166063 0.10199178069759131 0.12571418930764475 0.015796121051677214 0.044823718879143326 1.2196980840215498e-07 6.9137476583993855 0.5389126786720103 GSILQK(ub)HPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSILQKHPR 9 1 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 5054500.0 1314100.0 2056500.0 1683900.0 True False 1092732.3745007422 2045421.2263167084 2035995.7045260847 1.0 1.8718409686097564 1.8632153233826438 20.059508677326093 -10.371325137591507 4.960639432875001 0.9993398323308685 1.8675281459963764 0.9999258610779731 0.0035214049187277103 2.572852335582871e-05 3.260638964237255e-06 0.00341198322763883 0.0011365285503697642 4.2527990515622974e-11 10.371325137591507 0.8681883136655079 GSILQK(ub)HPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSILQKHPR 9 1 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 5167060.0 620410.0 564550.0 3982100.0 True False 803132.9751094257 533132.2962206658 3257398.659796412 1.0 0.6638157226056212 4.055864670919029 19.615279349661748 -6.882529256082251 1.0656230111578433 0.7837834111187769 4.308198072824824 0.975667741572637 0.23803338777224137 0.12541188825392832 0.25896390839031536 0.17166415841872826 0.4179175525821719 1.310601751204798e-07 6.882529256082251 3.5244146617060474 up GSILSFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSILSFLR 8 0 O43847-2;G3V1R5;O43847;F5H7V1 O43847-2 NRD1 Nardilysin 0 7610700.0 1348500.0 2465700.0 3796500.0 False True 1767896.5588925742 2097827.1712233215 3403674.5985995196 1.0 1.1866232561352 1.9252679583988845 20.75360243322856 -6.945118455628955 0.6100988894525038 0.991830961302317 2.158532409939088 0.9987602697701619 0.014067014219716442 0.0855073754804484 0.044547224078893444 0.014297475845657761 0.06228641638604294 1.1347012789601846e-07 6.945118455628955 1.166701448636771 GSILSFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSILSFLR 8 0 O43847-2;G3V1R5;O43847;F5H7V1 O43847-2 NRD1 Nardilysin 0 4382400.0 1818700.0 1112000.0 1451700.0 False True 1760966.364006048 1556027.399003392 1071456.2199335145 1.0 0.883621306351112 0.6084478623975776 20.747935922022474 -6.956645054868338 0.48039134343144824 1.0065806752733606 0.47400827227340425 0.999624807463812 0.0031800238984956465 0.08092213198670783 0.025730758874214107 0.0038829512004860097 0.02269915898277465 1.1049813426723266e-07 6.956645054868338 -0.5325724029999563 GSILSFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSILSFLR 8 0 O43847-2;G3V1R5;O43847;F5H7V1 O43847-2 NRD1 Nardilysin 0 10629300.0 1348500.0 3386900.0 5893900.0 False True 1847076.8918422556 3237255.5590194473 4501882.208680767 1.0 1.752637138885237 2.4373009204779965 20.816812494751453 -6.972253575005408 0.19705968317597355 0.5766848142360556 3.632097049632899 0.9999950377926962 0.0013075765541641139 0.0755780185103953 0.006339938573920379 0.022776158047020375 0.07323540402508578 1.0659735409641085e-07 6.972253575005408 3.0554122353968434 GSILSFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSILSFLR 8 0 O43847-2;G3V1R5;O43847;F5H7V1 O43847-2 NRD1 Nardilysin 0 4727600.0 1818700.0 1403300.0 1505600.0 False True 1512329.6320709977 1395740.1443667603 1820413.9988921368 1.0 0.9229073574756459 1.203715089810973 20.52834119745675 -6.8335301496170695 1.3121713492138023 0.9588976924710312 1.2118251171875014 0.9127322384478693 0.0349945667323214 0.1764959438684132 0.59308557691506 0.020932110677469726 0.04816967031597105 1.4671342318933518e-07 6.8335301496170695 0.25292742471647023 GSILSLSLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSILSLSLLR 10 0 Q9NTJ4-2;Q9NTJ4;Q9NTJ4-4;Q9NTJ4-3;A0A0C4DGU9 Q9NTJ4-2 MAN2C1 Alpha-mannosidase 2C1 0 13805200.0 0.0 6145800.0 7659400.0 False True 0.0 5874258.234557176 5850407.470294621 0.0 GSIPEFFHIMK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSIPEFFHIMKR 12 1 Q9NRN7;E9PLW6;E9PNF3 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 7824200.0 2793700.0 3481200.0 1549300.0 True False 3662567.7542292885 2961818.529611316 1388993.2979350039 1.0 0.8086726931375415 0.3792403011059897 21.804424017674474 -6.957728238675366 0.4663490220769773 1.011754336919286 0.15866186435084265 0.999676440881883 0.0046689673507517545 0.08052285171503018 0.0242070777188074 0.005897678367439394 0.0354535524521675 1.1022288174108213e-07 6.957728238675366 -0.8530924725684434 down GSIPEFFHIMK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSIPEFFHIMKR 12 1 Q9NRN7;E9PLW6;E9PNF3 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 11945000.0 4411800.0 2615800.0 4917400.0 True False 4271749.82389723 3660302.581216795 3629385.4211621354 1.0 0.8568625814040308 0.8496249946236203 22.026395727025783 GSIQNAK(ub)QALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSIQNAKQALR 11 1 Q9H6A9;Q9H6A9-3;H0YJ91;Q96RV3-4;Q96RV3-3;Q96RV3 Q9H6A9 PCNXL3;PCNX Pecanex-like protein 3;Pecanex-like protein 1 1 4677400.0 1257400.0 1287700.0 2132300.0 True False 1722294.7599573259 1230805.1561455433 1628694.6560969842 1.0 0.7146309590909047 0.9456538415859427 20.715900641406947 -9.9529289830551 6.0724548524658815 1.0000000744376691 0.8301424008559056 0.4188659323228142 0.09431469683672908 9.508931816206238e-08 1.6358522281499758e-08 0.09131985268043656 0.030439937512590352 1.1144767607837035e-10 9.9529289830551 -0.1698576735817635 GSIQNAK(ub)QALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSIQNAKQALR 11 1 Q9H6A9;Q9H6A9-3;H0YJ91;Q96RV3-4;Q96RV3-3;Q96RV3 Q9H6A9 PCNXL3;PCNX Pecanex-like protein 3;Pecanex-like protein 1 1 5527400.0 1173500.0 2314000.0 2039900.0 True False 975817.2448646366 2301534.0227069613 2466433.65856806 1.0 2.3585707619116993 2.527556949365246 19.896251453561437 -10.554690764161085 0.4180970824784066 9.448067236139443e-12 2.537755168318558 0.9993788502321974 0.017041166656564192 2.033644674212107 0.19854707878608827 2.1883201297200445 0.04104105903208453 2.7881057099077317e-11 10.554690764161085 2.53775516830911 GSIQNAK(ub)QALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSIQNAKQALR 11 1 Q9H6A9;Q9H6A9-3;H0YJ91;Q96RV3-4;Q96RV3-3;Q96RV3 Q9H6A9 PCNXL3;PCNX Pecanex-like protein 3;Pecanex-like protein 1 1 6714600.0 1044600.0 3235100.0 2434900.0 True False 1352255.2921443959 3055063.8411185434 1991773.1841837952 1.0 2.2592360028954643 1.4729268916561287 20.366936112913226 -10.074154383386142 4.860464722642832 0.9999730670664893 1.8660814472832599 0.6179698192051237 0.32100935046904305 9.526423786572602e-05 1.8145243438401548e-05 0.3108257605958927 0.10360532235776382 8.430350216578518e-11 10.074154383386142 0.8661083802167706 GSITISAEEIKDNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSITISAEEIKDNR 14 1 O75131;A0A087WYQ3;H0YB26;E5RHZ0;A0A087WXR6 O75131 CPNE3 Copine-3 0 12611800.0 6449900.0 2229100.0 3932800.0 False True 8455881.360920452 1896526.968963745 3525871.5820814422 1.0 0.22428495481602898 0.41697268819032235 23.01152370465257 -10.907745640144427 11.304255936826447 1.061551724170825 0.32062882150319133 0.9430999205104739 0.0786644377434119 0.03732430338313367 0.0003046041543256627 0.023296627283195495 0.02538883810991704 1.2366715216018812e-11 10.907745640144427 -0.7409229026676336 GSITISAEEIKDNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSITISAEEIKDNR 14 1 O75131;A0A087WYQ3;H0YB26;E5RHZ0;A0A087WXR6 O75131 CPNE3 Copine-3 0 27008100.0 6538800.0 14906000.0 5563300.0 False True 9919837.650312286 12245907.838890426 4463711.316518988 1.0 1.2344867194983693 0.4499782631400693 23.241885078746204 -6.826586211975535 1.3430043266226912 1.125623887978549 0.4302901686390676 0.898881775356915 0.10455415092192495 0.18506851269142308 0.6540019810649251 0.061144127338607246 0.14075219433912475 1.4907807905721194e-07 6.826586211975535 -0.6953337193394813 down GSITISAEEIKDNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSITISAEEIKDNR 14 1 O75131;A0A087WYQ3;H0YB26;E5RHZ0;A0A087WXR6 O75131 CPNE3 Copine-3 0 11117900.0 6449900.0 2170900.0 2497100.0 False True 8834602.331993608 2074982.4597937104 1907336.4093888185 1.0 0.2348699332260122 0.2158938611737616 23.074733766175463 GSITISAEEIKDNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSITISAEEIKDNR 14 1 O75131;A0A087WYQ3;H0YB26;E5RHZ0;A0A087WXR6 O75131 CPNE3 Copine-3 0 4432260.0 1043100.0 727460.0 2661700.0 False True 867383.86716515 723541.028590495 3218249.1636896953 1.0 0.834164729112644 3.710294006513889 19.72631108459969 -6.893226007411653 1.0030852997134978 0.8572007088318229 3.973904604873904 0.9828846833243785 0.17248977840070795 0.11656539461986423 0.20686186792969413 0.1304354633134204 0.3291968642892458 1.2787156856768936e-07 6.893226007411653 3.116703896042081 up GSITISAEEIKDNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSITISAEEIKDNR 14 1 O75131;A0A087WYQ3;H0YB26;E5RHZ0;A0A087WXR6 O75131 CPNE3 Copine-3 0 26158500.0 6538800.0 15789900.0 3829800.0 False True 8464605.499017598 14911178.184562363 3132815.69706645 1.0 1.761591628374524 0.3701077028846819 23.013011400838653 -6.758078544805869 1.6195625293693208 1.4434245640589594 0.36547578805400033 0.6831391684727948 0.32024641911715823 0.28615253487973946 1.4788356221226135 0.15604471459638636 0.3757359627592762 1.7455064388864232e-07 6.758078544805869 -1.077948776004959 GSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSR 36 0 P06576;H0YH81;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 172587000.0 33658000.0 110930000.0 27999000.0 False True 51061646.729401544 91133674.79995407 22464985.377602372 1.0 1.784777433499395 0.43995810586866413 25.605736729375927 -6.748532470927826 1.655167864452006 1.4622876311942679 0.437573158924854 0.6425869777953102 0.32975055547956533 0.30265782908580396 1.6308856844561799 0.1574049745854657 0.38274358745801956 1.7842985767686421e-07 6.748532470927826 -1.024714472269414 GSK(ub)PGKNVQLQENEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSKPGKNVQLQENEIR 16 2 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5 P36873 PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase 1 5699230.0 780530.0 1401100.0 3517600.0 True False 755752.5023905217 1960566.5366399765 2596235.0342619894 1.0 2.5941912602849557 3.435297966000556 19.5275543252404 -8.939608285872218 0.23601370732815274 1.1887107245044567e-15 4.095323495588537 0.9993031415274424 0.026660144001489743 0.4254772776618789 0.07761329162255773 0.7197391635076202 0.37359734038104153 1.1491896716895479e-09 8.939608285872218 4.095323495588536 GSKPGK(ub)NVQLQENEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSKPGKNVQLQENEIR 16 2 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5 P36873 PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase 1 4354360.0 960660.0 1836300.0 1557400.0 True False 1259434.5630446726 1562331.1978413388 1396255.1876356911 1.0 1.2405020821918815 1.1086365489765946 20.264344734648862 -10.466033448492304 4.57718313479926 0.999372078704708 1.1745693155843457 0.7003070441250936 0.05383387850661558 0.00034617941656023987 4.0384576710840655e-05 0.052309633587846856 0.017374809576437677 3.4195310495533257e-11 10.466033448492304 0.17519723687963773 GSKPGK(ub)NVQLQENEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSKPGKNVQLQENEIR 16 2 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5 P36873 PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase 1 10525000.0 2377400.0 2116200.0 6031400.0 True False 2301930.7383229653 2961209.6958372104 4451595.40187849 1.0 1.2864026039265422 1.9338528860871063 21.134412994896298 -6.957580798455838 0.46828895655256497 0.9826116085029012 2.2641096230883293 0.9996696688324836 0.007099634872770144 0.08057696825383703 0.02441264509130395 0.00892354075799316 0.053444421849716796 1.1026030806233318e-07 6.957580798455838 1.281498014585428 GSKPGK(ub)NVQLQENEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSKPGKNVQLQENEIR 16 2 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5 P36873 PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase 1 38670700.0 4630400.0 4637300.0 29403000.0 True False 7024655.327583969 3809737.583609731 23591484.16220731 1.0 0.542338008905561 3.3583831607466594 22.743996008980247 -6.86522153536747 1.1589973498787751 0.7472923427684357 3.5090463256501923 0.9596811200328983 0.24775224680355096 0.14152330883768882 0.35830801161645115 0.1663282461405083 0.39085879285263286 1.363887234731518e-07 6.86522153536747 2.7617539828817566 up GSKPGK(ub)NVQLQENEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSKPGKNVQLQENEIR 16 2 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5 P36873 PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase 1 5403660.0 960660.0 2023600.0 2419400.0 True False 1315841.96286035 1934190.660849669 1847987.549107086 1.0 1.469926264279614 1.404414512735229 20.327554796171754 -10.59638013956677 6.284743607990578 0.9987294185876477 1.4371703885073288 0.9834367834963353 0.026745060573288574 0.0004773638711788575 3.06572587395183e-05 0.025962255021884196 0.008631931182804607 2.5329105938978446e-11 10.59638013956677 0.43844096991968107 GSLEK(ub)GSPEDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSLEKGSPEDK 11 1 P0DN79;P35520;P35520-2;C9JMA6 P0DN79 CBS Cystathionine beta-synthase 1 1984760.0 689510.0 904620.0 390630.0 True False 667621.8824686919 1265839.4835309791 288312.2843511944 1.0 1.8960425306166333 0.43184966209479325 19.348671716752186 -6.741101846086839 1.6828073408675037 1.5324525340045645 0.4307989808363435 0.6098678904494412 0.3764683212668606 0.31579976209041066 1.7563969013858476 0.1769565485474883 0.4336869955764732 1.815089957417684e-07 6.741101846086839 -1.101653553168221 GSLLFTAGPLEEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSLLFTAGPLEEER 14 0 P53004 P53004 BLVRA Biliverdin reductase A 0 39160100.0 9611100.0 14382000.0 15167000.0 False True 12600245.174024781 12236261.660596913 13597664.332137235 1.0 0.9711129816602129 1.0791587103534 23.586948469992954 -6.835571723799545 1.3028776088791307 0.9846137864827762 1.0824103344429872 0.9165540127752762 0.01319364942926159 0.17403699544662193 0.5757817030013826 0.007946016120909345 0.018289287856935437 1.460253568428375e-07 6.835571723799545 0.09779654796021098 GSLLFTAGPLEEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSLLFTAGPLEEER 14 0 P53004 P53004 BLVRA Biliverdin reductase A 0 36953500.0 11933000.0 5357500.0 19663000.0 False True 11554193.446793951 7496777.688993414 14512670.422644276 1.0 0.6488360891234355 1.2560522280913724 23.461913218614814 -6.749881142995119 1.650059796658559 0.7934838599616666 1.257264614560392 0.6485427918400992 0.1475613323472745 0.3002562767375478 1.6083703562856912 0.07064198885997874 0.1715361809594386 1.7787661532475694e-07 6.749881142995119 0.4637807545987255 GSLLFTAGPLEEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSLLFTAGPLEEER 14 0 P53004 P53004 BLVRA Biliverdin reductase A 0 39927100.0 9611100.0 12231000.0 18085000.0 False True 13164583.40021142 11690593.977491744 13813695.472266536 1.0 0.8880337206344103 1.049307452603832 23.650158531515846 -6.720008873423316 1.7594757108762236 0.9318797050887592 1.0490523880966354 0.5124269731312617 0.04711596303592456 0.35532353902796665 2.1497955088144813 0.02126321371126994 0.05337417471064298 1.9054217863453292e-07 6.720008873423316 0.1171726830078762 GSLLFTAGPLEEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSLLFTAGPLEEER 14 0 P53004 P53004 BLVRA Biliverdin reductase A 0 25634100.0 11933000.0 5901000.0 7800100.0 False True 9922818.221533624 5869210.141743208 9431064.846412433 1.0 0.5914862099364439 0.9504421663137966 23.24231849404909 -10.221318403132642 7.814398971293499 1.0000001883539464 0.7709641881251202 0.35184010948985167 0.14654315554287525 4.809368378454791e-07 4.7890535009702216e-08 0.14188991651574473 0.047296600076519896 6.007331483019934e-11 10.221318403132642 -0.2290360002288262 GSLLFTAGPLEEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSLLFTAGPLEEER 14 0 P53004 P53004 BLVRA Biliverdin reductase A 0 23230000.0 7300000.0 15930000.0 0.0 False True 9449993.904512824 15043481.49640458 0.0 1.0 1.5919038306702609 0.0 23.171881968083074 -6.822411849845609 1.471345332474158 1.3230496545435242 2.6337294791519427e-20 0.8485894204294 0.2556376776117287 0.2030255859715421 0.8805201419893336 0.13877412336571504 0.30372850826055 1.50517899884463e-07 6.822411849845609 -1.3230496545435242 GSLPLSAHGIVVAWLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSLPLSAHGIVVAWLSR 17 0 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3;Q9Y4W2-4 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 0 7167100.0 1817400.0 1722000.0 3627700.0 False True 1759707.6317944627 2409603.5801113686 2677496.5413327897 1.0 1.3693204124222467 1.5215576115916547 20.746904320233156 -11.991664879621958 0.14753568811854242 4.979020964180225e-17 1.7149471129469176 0.9996122969380858 0.004311880480929138 5.414632456227983 0.10050995233894561 1.8218867006608497 0.15143138691156052 1.0193776804884663e-12 11.991664879621958 1.7149471129469176 GSLPLSAHGIVVAWLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSLPLSAHGIVVAWLSR 17 0 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3;Q9Y4W2-4 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 0 7450200.0 1817400.0 2293200.0 3339600.0 False True 1511248.6244712316 2280846.0764354393 4037894.9194342415 1.0 1.5092460892948578 2.671893197485658 20.527309595667433 -6.957376521762027 0.4709599353124183 0.9695759842719532 3.259302702020385 0.9996601590664879 0.01289893663341434 0.08065204312903385 0.024698235576035364 0.01610461744415234 0.09595312008987882 1.103121827927573e-07 6.957376521762027 2.2897267177484317 GSLPLSAHGIVVAWLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSLPLSAHGIVVAWLSR 17 0 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3;Q9Y4W2-4 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 0 16320200.0 5209400.0 5525700.0 5585100.0 False True 6743670.992625914 5218189.937519315 4568669.107965389 1.0 0.7737907058670737 0.6774750893039042 22.68510272172435 -13.999999999509056 0.11667525337980014 2.0813615487320583 0.5166300900874546 0.9997093983691812 0.002304460691930676 11.97771777674805 0.10467966084962724 3.0173402565126 0.1427257134760762 1.0000000011304407e-14 13.999999999509056 -1.5647314586446037 GSLRPNGIIVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSLRPNGIIVIK 12 1 Q9BV86;S4R338 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 0 20749800.0 6110800.0 5221900.0 9417100.0 False True 8011317.977071376 4442812.874806777 8442708.827201782 1.0 0.5545670372243663 1.0538476754218293 22.933608175574797 -6.671439227196828 1.93213721616448 0.7160285244675401 1.0518456353873982 0.28539189727399483 0.18914901818445434 0.45788596738079995 3.296808377005575 0.07877062536529521 0.21007145465613086 2.1308887316376424e-07 6.671439227196828 0.3358171109198581 GSLRPNGIIVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSLRPNGIIVIK 12 1 Q9BV86;S4R338 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 0 12209400.0 3555200.0 1095100.0 7559100.0 False True 3442342.122018088 1532379.1408710575 5579144.941860881 1.0 0.44515596839418553 1.6207409792813048 21.71495905810572 -6.77838181594057 1.5422960872133946 0.685164054874251 1.6295623096285554 0.7615491614189152 0.23447964983311223 0.25311523144329195 1.1891304379285463 0.11976036345778042 0.2829546318098235 1.6657820734774033e-07 6.77838181594057 0.9443982547543044 GSLRPNGIIVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSLRPNGIIVIK 12 1 Q9BV86;S4R338 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 0 18629000.0 6110800.0 3880600.0 8637600.0 False True 8370127.898160669 3709142.260571861 6597576.7769560125 1.0 0.443140452057721 0.7882289084741257 22.99681823709769 -10.46913553787674 6.226018032047211 1.000190333828371 0.6156846802659367 0.6231657814663969 0.14088177239081057 0.00037238718222566897 3.1751845893235816e-05 0.13647472503248453 0.045469396521149404 3.3951929632780404e-11 10.46913553787674 -0.3845056535624344 GSLRPNGIIVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSLRPNGIIVIK 12 1 Q9BV86;S4R338 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 0 9435600.0 3555200.0 2736400.0 3144000.0 False True 2956306.3220645553 2721658.470067128 3801395.863786453 1.0 0.9206280315926263 1.285859937928125 21.495364333539996 -6.849788900546536 1.2360520489547515 0.9576501168296796 1.300405426892988 0.9400020928724984 0.03841895635687425 0.1576927448366652 0.46372197436500884 0.024322389559752043 0.056277872137121494 1.4132243099354945e-07 6.849788900546536 0.3427553100633085 GSLSSLK(ub)EEGGLYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSLSSLKEEGGLYR 14 1 A0A3B3IUD2;Q9BUK6-7;Q9BUK6-3;Q9BUK6-2;Q9BUK6;Q9BUK6-4 A0A3B3IUD2 MSTO1 Protein misato homolog 1 1 30088000.0 1904200.0 8748800.0 19435000.0 True False 2888810.615667197 7187508.2853136035 15593663.731336907 1.0 2.4880510499140436 5.397952931481944 21.462044196281894 -6.96048244481432 0.42858070517066094 0.8826591391194281 7.114673737265111 0.9997876750050598 0.026614127496273447 0.07952923305167416 0.020497885478018982 0.03789399887247153 0.24169255522710742 1.0952608274433794e-07 6.96048244481432 6.232014598145683 GSLTFEPLTLVPIQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSLTFEPLTLVPIQTK 16 0 Q5T6H7;Q9NQW7-2;Q9NQW7;Q9NQW7-4;Q9NQW7-3 Q5T6H7 XPNPEP1 Xaa-Pro aminopeptidase 1 0 5252200.0 1297300.0 2320200.0 1634700.0 False True 1700772.863071071 1974035.2040687655 1465556.925149648 1.0 1.1606695090985089 0.8617005580059082 20.69775905235879 -6.760709966883669 1.6096166727251624 1.0932415324333544 0.8605624948901119 0.6939486120424934 0.06758534007870563 0.28171609716546403 1.4386683795543256 0.03312553002319855 0.07955590143613551 1.7349622637385952e-07 6.760709966883669 -0.23267903754324248 GSLTFEPLTLVPIQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSLTFEPLTLVPIQTK 16 0 Q5T6H7;Q9NQW7-2;Q9NQW7;Q9NQW7-4;Q9NQW7-3 Q5T6H7 XPNPEP1 Xaa-Pro aminopeptidase 1 0 7198200.0 1297300.0 2809000.0 3091900.0 False True 1776946.8682142831 2684889.091879188 2361656.899679343 1.0 1.510956314961363 1.329053187759438 20.760969113881682 -10.220069284759624 4.751899355921325 0.9999173802478177 1.4200047513617597 0.8766698497686991 0.07426164071505509 6.501614051019442e-05 1.0671074024278303e-05 0.07191760902790258 0.023967841478600795 6.024634649679021e-11 10.220069284759624 0.420087371113942 GSNEEDTDTPLFIGK(ub)VR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSNEEDTDTPLFIGKVR 17 1 A6NHR9-2;A6NHR9;J3KTL8;A6NHR9-3;A0A2R8YE92 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 1 5240300.0 1277900.0 2266700.0 1695700.0 True False 1675339.2752012028 1928517.1955273973 1520245.2303029674 1.0 1.1511203874187148 0.9074252915848289 20.67602185658727 -6.738972917020274 1.690348299092732 1.090022868177874 0.9073113640470845 0.6003525074884193 0.06349618810732913 0.3196860868276467 1.793111896814784 0.02972094358194614 0.07301797032827281 1.8240094455805432e-07 6.738972917020274 -0.18271150413078963 GSNNDMK(ub)VLHQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSNNDMKVLHQVK 13 1 Q9NWK9-2;Q9NWK9 Q9NWK9-2 ZNHIT6 Box C/D snoRNA protein 1 1 3466000.0 636640.0 625360.0 2204000.0 True False 616430.211679117 875069.5092093173 1626706.2814172802 1.0 1.4195759595002377 2.6389139445100116 19.233578045523004 -6.952163643712755 0.5345683730087282 0.9813782797789651 3.1328987438625138 0.9993602905895953 0.01758159233208503 0.08262849780825725 0.03245617341917061 0.019485326358163364 0.10089540851894331 1.1164424889943147e-07 6.952163643712755 2.1515204640835486 up GSNNDMK(ub)VLHQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSNNDMKVLHQVK 13 1 Q9NWK9-2;Q9NWK9 Q9NWK9-2 ZNHIT6 Box C/D snoRNA protein 1 1 3822630.0 636640.0 2309000.0 876990.0 True False 529394.3679340626 2296560.9586993824 1060364.5542563875 1.0 4.338091029682856 2.0029766436587 19.01398332095728 -6.552809096398667 2.37593731785436 3.3088991594361747 2.005829453202701 0.0 1.4600487848039874 0.7845477939503035 8.292017183722464 0.525423130901635 1.6469365892828742 2.800211943307683e-07 6.552809096398667 -1.3030697062334737 GSNNDMK(ub)VLHQVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSNNDMKVLHQVK 13 1 Q9NWK9-2;Q9NWK9 Q9NWK9-2 ZNHIT6 Box C/D snoRNA protein 1 1 11657600.0 1223800.0 1488600.0 8945200.0 True False 1584233.224704493 1405758.101415433 7317265.385502852 1.0 0.8873428984407576 4.6188056603015255 20.595353308375728 -6.899936443656981 0.9616467458027133 0.8445887747812728 5.010011829400349 0.9865353238609962 0.2011026909947261 0.11145285608359772 0.17767394515530194 0.15685907987743716 0.4080008209412698 1.2591096613151995e-07 6.899936443656981 4.165423054619076 up GSNNVALGYDEGSIIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSNNVALGYDEGSIIVK 17 0 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 0 6923600.0 2478300.0 1781000.0 2664300.0 False True 3249075.2998913396 1515281.742283625 2388623.7937702364 1.0 0.4663732300492701 0.7351703402657735 21.631597748978322 -10.264062577046385 4.911242708364484 1.0000970175382229 0.6007717851571882 0.7462734157155971 0.1097359607287526 0.0001166006114309495 1.7472406351104656e-05 0.10627707719790337 0.03541712903170079 5.4442420166585105e-11 10.264062577046385 -0.3993252323810347 GSNNVALGYDEGSIIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSNNVALGYDEGSIIVK 17 0 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 0 7002800.0 2478300.0 2229300.0 2295200.0 False True 3394594.4835392414 2130802.1546907322 1753121.0311277944 1.0 0.6277044769333198 0.5164449066387368 21.694807810501214 -13.999999999999968 0.16926552195189393 2.873914203268775 0.4175299043640089 0.9995150983926026 0.004553311415420543 12.084489072070747 0.13026880211054692 7.4349480230506355 0.0913189510633822 1.0000000000000737e-14 13.999999999999968 -2.4563842989047657 GSNTIASAAADKIPGLLGVFQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSNTIASAAADKIPGLLGVFQK 22 1 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 5376000.0 1921800.0 1680800.0 1773400.0 False True 2519498.4107376738 1430031.191707084 1589905.5796539977 1.0 0.5675856692794622 0.6310405169846866 21.264705115601437 -10.509731214708378 6.211078052859479 1.0003611664987493 0.5993130931321217 0.9815376258963019 0.025905333097302675 0.00012967168490484588 1.0235575440984964e-05 0.02510466699590595 0.008360910305317416 3.0922086114378125e-11 10.509731214708378 -0.4010480733666276 GSNTIASAAADKIPGLLGVFQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSNTIASAAADKIPGLLGVFQK 22 1 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 12223600.0 4539300.0 2008700.0 5675600.0 False True 4395202.406187197 2810784.3852321194 4188990.0956496918 1.0 0.6395119326644282 0.9530824086173558 22.06749817466524 -10.17459016496872 7.443048117765853 1.0000001463632155 0.796297170640892 0.3600742760837199 0.12801461074772258 3.1096130679043595e-07 3.44929139965762e-08 0.12394970252922506 0.04131653795809621 6.689749180636675e-11 10.17459016496872 -0.20370297572232354 GSNTIASAAADKIPGLLGVFQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSNTIASAAADKIPGLLGVFQK 22 1 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 15114700.0 1921800.0 2281900.0 10911000.0 False True 2632341.394692214 2181078.1127657956 8334046.519098716 1.0 0.8285696213886488 3.1660203862247025 21.32791517712433 -6.8892496829299 1.0267783153749652 0.8721381106910259 3.364156544160149 0.9804148680342982 0.14887312455234286 0.11975536292620305 0.2254043220565951 0.11057940726194816 0.27495061159912737 1.2904771440968228e-07 6.8892496829299 2.492018433469123 up GSNTIASAAADKIPGLLGVFQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSNTIASAAADKIPGLLGVFQK 22 1 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 13386700.0 4539300.0 2652600.0 6194800.0 False True 3774629.075086535 2638309.9173001247 7490104.038481014 1.0 0.6989587227824869 1.9843284967833033 21.847903450099516 -6.844996568625912 1.25901683927955 0.8398030768132803 2.030954822095395 0.9327015832273298 0.14239747917668882 0.16304570321073336 0.4998690037071299 0.08860586088639386 0.204485835261051 1.4289052482909139e-07 6.844996568625912 1.1911517452821145 GSNTTSHLHQAVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSNTTSHLHQAVAK 14 0 P22695;H3BRG4;H3BSJ9 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 8069590.0 839890.0 4083700.0 3146000.0 False True 1101103.9235063298 3474427.878137922 2820482.0985629107 1.0 3.155404139396792 2.561503994628802 20.070519207937362 -10.280573634997056 5.1549514225459205 0.9996364669774375 2.8584540670131786 0.9288568256099128 0.24245871880910294 0.0010131748694743757 0.00014140056268521412 0.23480111122558495 0.07825321500734563 5.241147293784932e-11 10.280573634997056 1.8588176000357413 GSNTTSHLHQAVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSNTTSHLHQAVAK 14 0 P22695;H3BRG4;H3BSJ9 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 6042660.0 2252900.0 705860.0 3083900.0 False True 2181382.922675114 987713.5790112729 2276134.074983103 1.0 0.45279238630877405 1.0434362767412666 21.056811614017892 -11.967914879667656 14.592071067865987 0.9093515306936386 0.7733028983725193 0.0 0.2751306394779135 0.0 0.0 0.0 0.08001647678847479 1.0766762180534435e-12 11.967914879667656 -0.1360486323211193 GSNTTSHLHQAVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSNTTSHLHQAVAK 14 0 P22695;H3BRG4;H3BSJ9 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 9732190.0 839890.0 4305900.0 4586400.0 False True 1150420.0301738179 4115651.1002928438 3503186.7798730033 1.0 3.57752037720606 3.0451371568554 20.133729269460254 -10.116853046403204 5.156819086769639 0.9999354892496487 3.3113287670340137 0.9617315903649027 0.2173445395912467 0.0001612042431019557 2.7607895426173586e-05 0.21044869519228257 0.07014764851718974 7.64094288839683e-11 10.116853046403204 2.311393277784365 GSPGVVHLVAFHPDPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSPGVVHLVAFHPDPTR 17 0 Q12788;J3KNP2;A0A087WYP7 Q12788 TBL3 Transducin beta-like protein 3 0 12719100.0 3972800.0 2917600.0 5828700.0 False True 5208379.2726499215 2482305.4527157247 5225602.036838416 1.0 0.4765984431569201 1.0033067415575772 22.312403078282436 -10.940370113832776 10.378302877370272 1.0625454194744046 0.7399525923572486 0.24529159141553825 0.21502776239519847 0.11961356766658364 0.0006872545494408976 0.08002807837990263 0.06939991189407076 1.1471755604519048e-11 10.940370113832776 -0.322592827117156 GSPGVVHLVAFHPDPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSPGVVHLVAFHPDPTR 17 0 Q12788;J3KNP2;A0A087WYP7 Q12788 TBL3 Transducin beta-like protein 3 0 10084400.0 3972800.0 2213800.0 3897800.0 False True 5441651.520883139 2115986.995942381 2977219.9177108384 1.0 0.3888501473903592 0.5471169747429284 22.375613139805328 -10.474570129441194 9.324948200738708 1.0000067037641396 0.4679835610670827 0.9377582426372525 0.06461216170382572 9.005073917236299e-06 5.073650903701518e-07 0.06256124392628098 0.0208534855201148 3.352971566272859e-11 10.474570129441194 -0.5320231426970569 GSPMEISLPIALSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSPMEISLPIALSK 14 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 12123500.0 1770800.0 6525000.0 3827700.0 False True 2321535.9484515963 5551495.434250794 3431646.3218910587 1.0 2.391302808794969 1.4781792735881936 21.146648190203464 -10.528750364711925 5.509074720150185 0.9976311265590995 1.9347410411915824 0.5828487310163604 0.3727811222304895 0.010863774260548867 0.0009292927297852432 0.36152978199847763 0.1203145898482658 2.95971324008472e-11 10.528750364711925 0.9371099146324829 GSPMEISLPIALSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSPMEISLPIALSK 14 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 5731300.0 2113000.0 1181700.0 2436600.0 False True 2045923.971597724 1653558.972484093 1798381.363566853 1.0 0.8082211242643482 0.8790069369794044 20.964321103538932 -10.792965640286798 9.731798812814402 1.0015114056659298 0.8436140312197293 0.866807222751554 0.028898187030016845 0.000955714344114514 2.0331806418077177e-05 0.02821873063219356 0.009326849758570213 1.6107730683224953e-11 10.792965640286798 -0.15789737444620044 GSPMEISLPIALSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSPMEISLPIALSK 14 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 12399500.0 1770800.0 3299400.0 7329300.0 False True 2425512.6140706516 3153621.5983432513 5598270.2916717185 1.0 1.3001876716900023 2.3080771706548004 21.209858251726356 -6.948895763682038 0.5708363735853635 0.9874916984767507 2.6698465536448386 0.9991117653694515 0.01667391245913492 0.08393217407239928 0.03782075381827145 0.01764818441267147 0.08399432609905187 1.1248749261661422e-07 6.948895763682038 1.682354855168088 up GSQAWVLSCSPSSQGQHKHK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSQAWVLSCSPSSQGQHKHK 20 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 6752700.0 1575200.0 2180200.0 2997300.0 True False 2065102.4542584987 1854922.6583530398 2687168.1481317957 1.0 0.8982230661379332 1.3012275214677702 20.97778192800715 -6.839779229949856 1.2834488989956718 0.9458560620509989 1.3144225531532612 0.924070745691316 0.04714994210352254 0.16905563869566365 0.5410415364022735 0.028807879418320886 0.06636281302348845 1.4461747350297166e-07 6.839779229949856 0.36856649110226225 GSQAWVLSCSPSSQGQHKHK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSQAWVLSCSPSSQGQHKHK 20 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 6984900.0 1575200.0 2195800.0 3213900.0 True False 2157594.008179402 2098782.29546042 2454843.012348212 1.0 0.9727419929347099 1.1377687382528612 21.040991989530042 -6.864491287494151 1.1629158078902133 0.9849957685155286 1.1464703644603735 0.9588649389013112 0.014649917968865393 0.1422419048921955 0.36302551744119627 0.009806410607767104 0.023018363151742147 1.3661824827931365e-07 6.864491287494151 0.16147459594484492 GSQFGQSCCLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSQFGQSCCLR 11 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 8065070.0 859270.0 3862400.0 3343400.0 False True 1126511.2911825166 3286144.9755172837 2997457.0401574178 1.0 2.917099012889401 2.660831776493727 20.10343034330709 -10.211457829860244 5.283836846211416 0.9998780803334012 2.7889653946919952 0.9848430925301943 0.10462066116194113 0.00015026946362728752 2.2425432876787844e-05 0.10130519651491653 0.033766173195566324 6.145286997515396e-11 10.211457829860244 1.7890873143585941 GSQFGQSCCLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSQFGQSCCLR 11 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 9165670.0 859270.0 4056200.0 4250200.0 False True 1176965.3398986254 3876983.6719403183 3246390.295616655 1.0 3.2940508445849828 2.758271790651264 20.16664040482998 -10.018793436148554 5.244256159523569 0.9999885716157852 3.026161317608956 0.9501705327427913 0.21873088286332001 3.7049335428924095e-05 6.931308591241985e-06 0.2117867747548089 0.07059508888174888 9.576494506075288e-11 10.018793436148554 2.026172745993171 GSQK(ub)PQDPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSQKPQDPR 9 1 Q99942;A0A140TA09 Q99942 RNF5 E3 ubiquitin-protein ligase RNF5 1 38543500.0 11918000.0 19180000.0 7445500.0 True False 15624613.414076177 16318418.763054447 6675111.082279147 1.0 1.044404640971995 0.4272176792717031 23.897317159106596 -6.889606901801996 1.0246728734523523 1.0334752331193324 0.37453449014738205 0.9806466570221126 0.03910053614838149 0.11946397320323872 0.22369928008388312 0.029089293836749058 0.07242046131241024 1.28941612841348e-07 6.889606901801996 -0.6589407429719504 down GSQK(ub)PQDPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSQKPQDPR 9 1 Q99942;A0A140TA09 Q99942 RNF5 E3 ubiquitin-protein ligase RNF5 1 10732800.0 4494400.0 4441100.0 1797300.0 True False 4351727.732110184 6214454.390030551 1326533.212155753 1.0 1.4280430147722312 0.3048290917576564 22.05315686584303 -6.8034111145447556 1.4418665856223039 1.235152758221385 0.2879698159944585 0.8419898261849849 0.18398620084387862 0.2159111772514421 0.8857867888782754 0.10036742667626797 0.23295805575197276 1.5724935960148118e-07 6.8034111145447556 -0.9471829422269266 down GSQK(ub)PQDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSQKPQDPR 9 1 Q99942;A0A140TA09 Q99942 RNF5 E3 ubiquitin-protein ligase RNF5 1 24534000.0 11918000.0 9043100.0 3572900.0 True False 16324406.671839843 8643545.940467317 2729054.6061852975 1.0 0.5294860704112283 0.1671763428249438 23.960527220629487 -8.031476991815998 0.34012202613628006 1.0963844589216933 1.6385930946792633e-22 0.9986167163855426 0.012680939108279032 0.09606809580421714 0.07062195139004437 0.0557088464136989 0.0870531751253536 9.30085787814035e-09 8.031476991815998 -1.0963844589216933 down GSQK(ub)PQDPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSQKPQDPR 9 1 Q99942;A0A140TA09 Q99942 RNF5 E3 ubiquitin-protein ligase RNF5 1 9082500.0 4494400.0 2911600.0 1676500.0 True False 3737292.735679276 2895914.632892652 2027048.3987398176 1.0 0.7748696282862364 0.5423841647157963 21.833562141277305 -6.9707221269314426 0.2403145262151636 1.0831540212177817 0.22737287237893228 0.9999874787610418 0.0006610757203351775 0.07606910374618843 0.00818721264005639 0.005544929285829443 0.02265228150033159 1.0697391076121768e-07 6.9707221269314426 -0.8557811488388494 GSQVAVQK(ub)RPETR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSQVAVQKRPETR 13 2 Q5JUV4;Q5JUV3 Q5JUV4 NT5C2 1 10528500.0 462500.0 0.0 10066000.0 True False 701646.3132791084 0.0 8076450.687915473 1.0 0.0 11.51071492155441 19.420384452739558 -6.885744353169921 1.047191778054101 0.3169623115779983 12.422110921513148 0.9780331481385479 0.7716713382246179 0.1226655483675077 0.24254259501544106 0.5643617916622549 1.3870939241739308 1.300935146312408e-07 6.885744353169921 12.10514860993515 up GSQVAVQK(ub)RPETR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSQVAVQKRPETR 13 2 Q5JUV4;Q5JUV3 Q5JUV4 NT5C2 1 8614800.0 462500.0 2331300.0 5821000.0 True False 598715.3672379703 2201561.1056225994 4761637.728503793 1.0 3.6771414700427236 7.9530908826851485 19.191510774832008 -6.964192673529566 0.3716473035026509 0.6772562800658495 11.102201558087177 0.9998955244076755 0.02926870177255549 0.07823599678014173 0.015832460387471815 0.05622306824156572 0.36283542775892674 1.0859437408352825e-07 6.964192673529566 10.424945278021328 GSSAAGLTASVMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSSAAGLTASVMR 13 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 38142000.0 13684000.0 10991000.0 13467000.0 False True 17939856.5160445 9351185.64258244 12073564.024585737 1.0 0.5212519751325331 0.6730022625202019 24.09666501576086 -10.926233698658514 11.471630166159343 1.0574048130250084 0.5971271188263675 0.9038237194960864 0.061951795403415715 0.031523399092478144 0.00020270535745895853 0.020789459877944724 0.01999485598875651 1.1851308445510567e-11 10.926233698658514 -0.46027769419864095 GSSAAGLTASVMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSSAAGLTASVMR 13 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 43050300.0 4574500.0 28949000.0 9526800.0 False True 6939850.94074655 23782824.770430636 7643823.804255223 1.0 3.4269936016626046 1.1014391907721497 22.72647324518892 -6.636150320323849 2.058107783659081 2.5916734268224935 1.1109664238594898 0.14016083822009406 1.0394304808280486 0.5430992912815094 4.391696856851917 0.4119374820302124 1.151220841128548 2.311264664451114e-07 6.636150320323849 -1.4807070029630036 GSSAAGLTASVMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSSAAGLTASVMR 13 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 31872200.0 13684000.0 6120200.0 12068000.0 False True 18743344.596195366 5849789.327205049 9217786.94826169 1.0 0.3120995453710259 0.49178986711543304 24.15987507728375 -10.779651398288477 10.599916681370376 1.0027609880054764 0.4019447062459551 0.9365873026993401 0.07335826666505572 0.004786857193766167 9.950793106043866e-05 0.07103411540201152 0.023676278758366972 1.660919567909328e-11 10.779651398288477 -0.6008162817595213 GSSAAGLTASVMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSSAAGLTASVMR 13 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 20565800.0 4574500.0 10678000.0 5313300.0 False True 5921780.426875879 10083759.913283622 4346333.919061875 1.0 1.7028257021348991 0.7339572908404587 22.49759956728137 -6.712158533470931 1.7876077654757525 1.4311347826463072 0.7360984964923771 0.4752613106557506 0.296070129541961 0.370775996115287 2.3109531660611196 0.13173882431997214 0.3337932543034475 1.9401775121070554e-07 6.712158533470931 -0.6950362861539301 GSSASLVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSSASLVLK 9 0 Q00325-2;Q00325 Q00325-2 SLC25A3 Phosphate carrier protein, mitochondrial 0 19864200.0 6133400.0 5361600.0 8369200.0 False True 8040946.795930095 4561670.179353105 7503235.467035207 1.0 0.5673051066153034 0.9331283563314896 22.938933953486153 -10.076946374895725 7.28780474092562 1.000000046830496 0.7502167314733965 0.3833315402420393 0.14934671630856797 1.1365169539628619e-07 1.448775024325194e-08 0.14460436428041828 0.048201445422820594 8.376327035837407e-11 10.076946374895725 -0.2497833153570994 GSSASLVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSSASLVLK 9 0 Q00325-2;Q00325 Q00325-2 SLC25A3 Phosphate carrier protein, mitochondrial 0 7319420.0 2130700.0 916620.0 4272100.0 False True 2063062.0947862146 1282631.1461101542 3153108.849747173 1.0 0.6217123320483804 1.5283635222205538 20.97635581395718 -6.793375499515322 1.4826857285209065 0.7894910535272314 1.538938095935556 0.8120780720982888 0.16118609490383629 0.23037830596596684 1.00038260886058 0.08555013937673443 0.19982433628549637 1.6092536412746495e-07 6.793375499515322 0.7494470424083247 GSSASLVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSSASLVLK 9 0 Q00325-2;Q00325 Q00325-2 SLC25A3 Phosphate carrier protein, mitochondrial 0 13616800.0 6133400.0 3579500.0 3903900.0 False True 8401083.728902714 3421345.8541764147 2981879.223344279 1.0 0.40725053630947267 0.3549398291419897 23.002144015009044 -13.999999999999998 0.3436662452582846 8.011141807311315 0.3470949064397586 0.9997424581561081 0.004694631689198116 20.0453574668418 0.18828273076660512 102.28438068593232 0.01595374271945785 1.0000000000000041e-14 13.999999999999998 -7.664046900871556 GSSASLVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSSASLVLK 9 0 Q00325-2;Q00325 Q00325-2 SLC25A3 Phosphate carrier protein, mitochondrial 0 5742000.0 2130700.0 2340000.0 1271300.0 False True 1771771.456014558 2327393.9555463656 1537122.9521729378 1.0 1.3135971615558313 0.8675627699921066 20.756761089391457 -6.7177637645542285 1.7672714038883914 1.1912480872664113 0.8683419789183527 0.5018919900615932 0.1320012982464052 0.35972811691750817 2.194474479755214 0.05933335410316969 0.14934718904196795 1.9152974720234622e-07 6.7177637645542285 -0.32290610834805855 GSSAVGLTAYVMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSSAVGLTAYVMK 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 33767000.0 9577000.0 10461000.0 13729000.0 False True 12555539.743799938 8900259.576658621 12308454.777867207 1.0 0.70887112448142 0.9803206416470671 23.581820713447474 -10.49181325440069 8.340138891472119 1.0000089766538085 0.8445958832210514 0.30410781822829414 0.11081880133011648 1.8498153109017487e-05 1.1271003876078317e-06 0.10730603822704352 0.035766614333184114 3.222454141067133e-11 10.49181325440069 -0.1554130934327571 GSSAVGLTAYVMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSSAVGLTAYVMK 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 28430600.0 8915500.0 4518100.0 14997000.0 False True 8632482.332597967 6322200.891580235 11068835.799643828 1.0 0.7323734527328657 1.2822309242204535 23.04134404575883 -6.774324701152641 1.5576461936995398 0.8473506823406308 1.2858629302189013 0.7469424209743065 0.11293673693802046 0.2594772418139606 1.2429610704787049 0.057127752451004474 0.1354696853112593 1.68141647656296e-07 6.774324701152641 0.4385122478782705 GSSAVGLTAYVMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSSAVGLTAYVMK 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 17204500.0 6371500.0 0.0 10833000.0 False True 9666031.319043985 0.0 8691852.801727427 1.0 0.0 0.8992162879301628 23.204492238593872 -9.13417181114811 12.146317333233132 0.9999846158576131 0.44960814396500354 0.3331207107227071 0.3671035124122037 0.0 0.0 0.3554464474281253 0.11848214914270841 7.342233447518603e-10 9.13417181114811 -0.5503764718926096 GSSAVGLTAYVMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSSAVGLTAYVMK 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 31057800.0 9577000.0 9090800.0 12390000.0 False True 13117875.708693597 8689138.396744512 9463737.18005984 1.0 0.6623891390422283 0.7214382412380952 23.645030774970365 -10.624688155833343 6.536092428582672 1.0010854241931526 0.6919136901401653 0.9731873619505339 0.0241066950248886 0.0003825327471022846 2.1965576336265056e-05 0.023417187425521045 0.007780402363624568 2.3730770766444014e-11 10.624688155833343 -0.30917173405298726 GSSAVGLTAYVMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSSAVGLTAYVMK 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 19462600.0 8915500.0 4321100.0 6226000.0 False True 7413633.273617958 4297821.376628802 7527827.814228513 1.0 0.5797186370039321 1.0154033166189818 22.821749321193106 -10.958221337609876 12.13992742431435 1.0629657388454616 0.7975609768115682 0.22351860532074586 0.17786752563413988 0.09727864777465424 0.00033477686743943263 0.055268912964863526 0.057406497051012015 1.1009780545188055e-11 10.958221337609876 -0.2654047620338934 GSSGGSGAKPSDAASEAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSSGGSGAKPSDAASEAAR 19 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;H7C044 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 3384080.0 695320.0 296760.0 2392000.0 False True 673247.447198925 415257.81558295543 1765463.4415381749 1.0 0.6167982029648289 2.622309893462592 19.36077732880292 -6.857219289561943 1.1996762268822159 0.7934298236760172 2.714404584636724 0.9501691037339767 0.1940476644609737 0.14969903017472533 0.4109848968447053 0.12628913774124717 0.29394002188114826 1.389250975592647e-07 6.857219289561943 1.9209747609607066 up GSSGVGLTAAVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSSGVGLTAAVLR 13 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 114788000.0 31593000.0 29597000.0 53598000.0 False True 41418728.94704724 25181242.968202386 48052193.10832008 1.0 0.6079675453197984 1.160156149884598 25.30377994519806 -6.715976478175706 1.77344997568758 0.7604841090471041 1.1591292291402646 0.49368110248768426 0.16505412684907644 0.363163551422294 2.2298860877187034 0.07395750455794094 0.18656947843899763 1.9231958883057592e-07 6.715976478175706 0.39864512009316055 GSSGVGLTAAVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSSGVGLTAAVLR 13 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 60379800.0 18881000.0 9645800.0 31853000.0 False True 18281632.98993686 13497418.242182475 23509743.73048304 1.0 0.7383048467066449 1.2859761348137773 24.12389160776184 -6.776795464093578 1.5486047096099544 0.8512029933567035 1.2898673637069402 0.7557962896349731 0.11052555499371501 0.25558930100476235 1.2104879575917642 0.0562294570709489 0.13302403641835547 1.6718778187243547e-07 6.776795464093578 0.43866437035023675 GSSGVGLTAAVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSSGVGLTAAVLR 13 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 155577000.0 31545000.0 70360000.0 53672000.0 False True 47856071.24840966 57803708.274810895 43063705.67472673 1.0 1.2078657266862836 0.8998587755186405 25.51219862767618 -6.7249223711218065 1.741757871210164 1.1257946153056875 0.9002056563466986 0.5355749796008855 0.08742204875301846 0.34583681315359366 2.0529587444082593 0.03981479985101986 0.09937021736047133 1.8839858163912406e-07 6.7249223711218065 -0.2255889589589889 GSSGVGLTAAVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSSGVGLTAAVLR 13 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 51645000.0 18881000.0 16607000.0 16157000.0 False True 15700388.070122879 16517534.794768581 19535353.99847255 1.0 1.0520462756077154 1.244259308191715 23.904296883196118 -6.946710809660576 0.5938633913964075 0.9978024104621565 1.3082393693126406 0.9989171797985955 0.0034567558864495654 0.08483413516705152 0.04164113618000142 0.003569630368334135 0.016121601919542445 1.1305484797705923e-07 6.946710809660576 0.31043695885048417 GSSGVGLTAAVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSSGVGLTAAVLR 13 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 127755000.0 31545000.0 58782000.0 37428000.0 False True 40835624.344911925 55510730.02646917 30616488.043710683 1.0 1.3593701802525702 0.7497494781789829 25.28332494976863 -6.746969670816529 1.6611616362191521 1.2120792000526017 0.7488189587699149 0.6358115701874869 0.15099200706383956 0.3053481255963057 1.656851326525358 0.07183484267062888 0.17494710949995915 1.7907309063030023e-07 6.746969670816529 -0.46326024128268684 GSSGVGLTAAVTTDQETGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSSGVGLTAAVTTDQETGER 20 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 25207700.0 8465700.0 7559200.0 9182800.0 False True 11098614.681955406 6431396.8255308205 8232651.943637476 1.0 0.5794774401878512 0.7417729310868381 23.403876276264494 -10.234199818097721 5.040942908415357 1.0000468084062035 0.6606251856371278 0.8535918607715596 0.06625685671026198 3.4860110723169316e-05 5.295765707991898e-06 0.0641617544949653 0.02138430855079952 5.831767239925234e-11 10.234199818097721 -0.3394216227690757 GSSGVGLTAAVTTDQETGER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSSGVGLTAAVTTDQETGER 20 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 12574700.0 2930100.0 2345900.0 7298700.0 False True 2837085.579355651 3282630.1037068916 5386951.513693427 1.0 1.1570430330312529 1.8987624317335159 21.435978238811966 -6.9410848853654326 0.6494000262098815 0.9918052453293172 2.1053246503982828 0.9983024847064227 0.016148468578249506 0.08727531085418101 0.05238338460768396 0.015851600620058078 0.06353940428427156 1.1452890662030025e-07 6.9410848853654326 1.1135194050689656 GSSGVGLTAAVTTDQETGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSSGVGLTAAVTTDQETGER 20 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 35566200.0 7274900.0 21130000.0 7161300.0 False True 11036555.166430661 17359186.41055647 5745865.9160907045 1.0 1.5728808626225181 0.520621319736399 23.395786599022927 -6.758863043749119 1.6167960313086698 1.3332283693686175 0.5169945783560019 0.6863120905772182 0.24091670020424688 0.2848203841410721 1.4671418417446385 0.11758521833730673 0.2828887617396936 1.7423562447675476e-07 6.758863043749119 -0.8162337910126156 GSSGVGLTAAVTTDQETGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSSGVGLTAAVTTDQETGER 20 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 23938600.0 8465700.0 8569700.0 6903200.0 False True 11595698.06694029 8191062.3177917665 5272806.335866759 1.0 0.7063880303286569 0.4547209064454429 23.467086337787386 -7.111765304891491 0.18602798008725133 1.1890465615606822 1.4110778176768433e-14 0.9999949803332384 0.0004992056643254207 0.07795219003786107 0.006854542040849918 0.011308408858939092 0.030403915519841847 7.730982587477693e-08 7.111765304891491 -1.189046561560668 down GSSGVGLTAAVTTDQETGER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSSGVGLTAAVTTDQETGER 20 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 7986000.0 2930100.0 2601200.0 2454700.0 False True 2436507.975439177 2587186.8193022264 2967966.420749556 1.0 1.0618421303693413 1.2181230066421533 21.216383514246242 -6.955230164913876 0.498128391479331 0.9968187615723901 1.2898654876406492 0.9995503675317057 0.0019463197487191225 0.08145108654373488 0.027778273936840795 0.002290645359768492 0.012891020277818683 1.1085871368575065e-07 6.955230164913876 0.2930467260682591 GSSGVGLTAAVTTDQETGER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSSGVGLTAAVTTDQETGER 20 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 24143800.0 7274900.0 9874500.0 6994400.0 False True 9417501.459717853 9324975.394616885 5721490.96860451 1.0 0.9901750941588131 0.6075381026567873 23.166912921115376 -6.912412254499695 0.8791315046807402 1.0109626532031164 0.555447018975101 0.9918008045054851 0.016546688839275837 0.10284485307684385 0.13026909653352586 0.013710670039382259 0.03851191973098668 1.2234542825956133e-07 6.912412254499695 -0.45551563422801544 GSSK(ub)QQSEEDLLLQDFSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSSKQQSEEDLLLQDFSR 18 1 Q9UNL2-2;C9JA28;Q9UNL2 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 97281300.0 9280300.0 13328000.0 74673000.0 True False 12166563.170553055 11339514.3521371 66946554.273995034 1.0 0.932022806537702 5.502503322879789 23.536418355102356 -6.903524399100053 0.9387090049912757 0.8279110915040088 6.0181387893559934 0.9882398535754384 0.23192993921279556 0.10885766327857356 0.16314639425193064 0.18400324986286204 0.48779636694375905 1.2487502865747135e-07 6.903524399100053 5.190227697851984 up GSSK(ub)QQSEEDLLLQDFSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSSKQQSEEDLLLQDFSR 18 1 Q9UNL2-2;C9JA28;Q9UNL2 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 314049000.0 10972000.0 17677000.0 285400000.0 True False 10623699.86576916 24735518.28433723 210645178.18352643 1.0 2.3283336875920266 19.827854781764923 23.34078295845227 -6.922091266753653 0.8090632091422199 0.6422102953097991 22.790188390850727 0.9947424176512568 0.6220998291968466 0.0969569439297535 0.0993517534553564 0.5420253827195208 1.6575595977900694 1.1964890633469678e-07 6.922091266753653 22.147978095540928 up GSSK(ub)QQSEEDLLLQDFSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSSKQQSEEDLLLQDFSR 18 1 Q9UNL2-2;C9JA28;Q9UNL2 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 165424300.0 9280300.0 12904000.0 143240000.0 True False 12711477.700677585 12333858.612178378 109409662.12040137 1.0 0.9702930613268449 8.607155257375725 23.599628416625247 -6.90602333828961 0.9223888279418563 0.7327943863723925 9.514544293417277 0.9893324120807827 0.3711066819709777 0.1071068195027759 0.15346562023708607 0.29797833151382896 0.8015657006777289 1.2415855849796355e-07 6.90602333828961 8.781749907044885 up GSSK(ub)QQSEEDLLLQDFSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSSKQQSEEDLLLQDFSR 18 1 Q9UNL2-2;C9JA28;Q9UNL2 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 310444000.0 10972000.0 21082000.0 278390000.0 True False 9123704.142015174 20968427.081550617 336600061.87007344 1.0 2.298236193892985 36.89291724399645 23.121188233886546 -6.914833657141625 0.8621738472232858 0.08558290208976523 41.858613167229606 0.9926213012883844 1.4278652339056135 0.10130759599400974 0.12207269598939113 1.1977059853492227 3.428139476325243 1.2166519117092747e-07 6.914833657141625 41.77303026513984 up GSSLHLHVSKPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSSLHLHVSKPPR 13 1 K7EMW4;Q969V3-2;Q969V3;K7ENM2;A0A0C4DGP7;K7ELZ9;K7EQ66 K7EMW4 NCLN Nicalin 0 4555190.0 1264400.0 623390.0 2667400.0 False True 1224262.3140975698 872312.8779359048 1968727.919715271 1.0 0.7125212202410277 1.6080932142115827 20.22348127662113 -6.820339086152534 1.37055948490803 0.8451068443441244 1.6277626846045157 0.885129488671498 0.12653575659553898 0.19304146925348908 0.7124515481426303 0.07255181084254081 0.1671927306229002 1.5123799592965186e-07 6.820339086152534 0.7826558402603913 GSSLHLHVSKPPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSSLHLHVSKPPR 13 1 K7EMW4;Q969V3-2;Q969V3;K7ENM2;A0A0C4DGP7;K7ELZ9;K7EQ66 K7EMW4 NCLN Nicalin 0 3621800.0 1264400.0 1295200.0 1062200.0 False True 1051404.6224174255 1288222.5005229285 1284301.1089421036 1.0 1.2252395253513375 1.2215098560145137 20.003886552055405 -9.994864675700128 4.658621840036372 0.9999953603140442 1.2233746906939622 0.9997909503391921 0.0015226311771676388 1048850.086972935 0.006621534749326375 52.20089949996399 0.0005212371446003988 1.0118947071970206e-10 9.994864675700128 0.22337933037991797 GSSLK(ub)ILSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSSLKILSK 9 1 P61073;P61073-2 P61073 CXCR4 C-X-C chemokine receptor type 4 1 4917100.0 1360600.0 1934800.0 1621700.0 True False 1783759.7760691429 1646135.3817913309 1453902.0404448446 1.0 0.9228458920734867 0.8150772654201212 20.76648990587753 -6.966415002399282 0.33287881253932383 1.0126966462805511 0.7216833429672429 0.9999394022666463 0.0005903328346807264 0.0774840481801428 0.013184755415186088 0.0015567915863723843 0.009378322086950563 1.080401050027582e-07 6.966415002399282 -0.2910133033133082 GSSLK(ub)ILSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSSLKILSK 9 1 P61073;P61073-2 P61073 CXCR4 C-X-C chemokine receptor type 4 1 2606810.0 941310.0 1665500.0 0.0 True False 911428.6292970441 2330542.8354677632 0.0 1.0 2.5570217574416514 0.0 19.797770162856384 -6.7427644932296085 1.682457499305941 1.9243285675749124 4.3424350924121563e-07 0.6133742483414315 0.6542024399271705 0.3136357480741542 1.745282682822693 0.3078136470766842 0.7513536155265085 1.8081543759957025e-07 6.7427644932296085 -1.9243281333314033 GSSLK(ub)ILSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSSLKILSK 9 1 P61073;P61073-2 P61073 CXCR4 C-X-C chemokine receptor type 4 1 4516400.0 1360600.0 1308700.0 1847100.0 True False 1863650.5888324624 1250877.30670783 1410853.022218607 1.0 0.6711973339870957 0.7570373066028844 20.829699967400423 -9.897776980182474 6.359555478215535 1.0000000279601438 0.7141173202949629 0.9366642835442789 0.035044022073960124 1.3894759294626457e-08 2.3851422250094913e-09 0.03393123200839651 0.011310409489699719 1.2653859843326238e-10 9.897776980182474 -0.28588270766518087 GSSLK(ub)ILSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSSLKILSK 9 1 P61073;P61073-2 P61073 CXCR4 C-X-C chemokine receptor type 4 1 5552210.0 941310.0 3190500.0 1420400.0 True False 782740.972103564 3173312.143235338 1717399.0728124315 1.0 4.054102514535906 2.194083527015376 19.57817543829066 -9.848385795569422 6.3453647730330545 0.9999998956886429 3.124093020776093 0.6348773428794895 0.7593495718872012 1.1258045871535979e-06 2.0028524340545067e-07 0.7352371052882686 0.24507902048883348 1.4177974941388546e-10 9.848385795569422 2.12409312508745 GSSNSYAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSSNSYAIK 9 0 M0R0F0;P46782;M0R0R2;M0QZN2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 0 5914200.0 528300.0 2704200.0 2681700.0 False True 692606.4160644776 2300743.90088904 2404223.4086828264 1.0 3.3218633953209786 3.4712693283208154 19.401676226657962 -10.31549907275223 0.5697328081538944 1.0927831373649764e-23 3.457187375604752 0.9996868525389665 0.02002117977768183 1.643974625556539 0.272689558591423 2.5968978360423005 0.027018280592411643 4.836162968540855e-11 10.31549907275223 3.457187375604752 GSSNSYAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSSNSYAIK 9 0 M0R0F0;P46782;M0R0R2;M0QZN2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 0 4874100.0 528300.0 2229300.0 2116500.0 False True 723626.7867706821 2130802.1546907322 1616626.2906857673 1.0 2.9446148120080373 2.2340608725946427 19.464886288180853 -10.284187151511528 5.584902703296203 0.999840238874478 2.589337842301372 0.8696352819523917 0.29008243104799514 0.0005771009614706526 7.396573027239785e-05 0.28089813387900847 0.09362370203967069 5.197719617482171e-11 10.284187151511528 1.5894976034268942 GSSNSYAIK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSSNSYAIKK 10 1 M0R0F0;P46782;M0R0R2;M0QZN2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 1 126521500.0 2649500.0 68698000.0 55174000.0 True False 3473520.1577944946 58448526.182706624 49465123.74637956 1.0 16.826885559178216 14.240632413023723 21.727967039036294 -9.212164275234501 11.16267933144779 1.000000000987815 15.533758984391108 0.9768018217938734 1.0558334256245334 0.0 0.0 1.0223063184531576 0.34076877281771917 6.135298888592806e-10 9.212164275234501 14.533758983403294 GSSNSYAIK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSSNSYAIKK 10 1 M0R0F0;P46782;M0R0R2;M0QZN2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 1 302100700.0 2544100.0 298070000.0 1486600.0 True False 3859585.6986235213 244877079.66846055 1192772.8584000727 1.0 63.446467779117654 0.3090416825892639 21.880014561216417 -3.039255037248564 3.5124502964467146e-24 9.183407672254537 48.39655091121183 0.0 30.465931521439483 0.0 0.29100059156938723 1136219012.5462146 1136218970.9037468 0.0009135765906583677 3.039255037248564 39.213143238957294 GSSQPNLSTSHSEQEYGK(ub)AGGSPASYHGSTSPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSSQPNLSTSHSEQEYGKAGGSPASYHGSTSPR 33 1 F6PQP6;I3L2B2;O95208-3;O95208-2 F6PQP6 EPN2 Epsin-2 1 22203100.0 8223100.0 7836600.0 6143400.0 True False 10780563.73261368 6667409.826827549 5507739.899653979 1.0 0.6184657864093974 0.5108953516959229 23.361929285064623 -13.999999999999995 0.17759285283190399 2.9653082640896127 0.42328896111051373 0.9995012389235587 0.004686744811244822 12.174536523718766 0.13356794946405307 8.251943608789247 0.08198965030290313 1.0000000000000123e-14 13.999999999999995 -2.542019302979099 GSSQPNLSTSHSEQEYGK(ub)AGGSPASYHGSTSPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSSQPNLSTSHSEQEYGKAGGSPASYHGSTSPR 33 1 F6PQP6;I3L2B2;O95208-3;O95208-2 F6PQP6 EPN2 Epsin-2 1 32095700.0 10228000.0 8583700.0 13284000.0 True False 9903317.738524146 12011216.17340415 9804521.888542272 1.0 1.2128477032177032 0.9900239644339032 23.23948049684564 -6.656567154456949 1.9845919678270503 1.1373980067878682 0.9909515389370587 0.22105983502625492 0.090701858541597 0.4928089777476528 3.727371516129582 0.03696658954510143 0.10054280728692164 2.20512313437137e-07 6.656567154456949 -0.1464464678508095 GSSQPNLSTSHSEQEYGK(ub)AGGSPASYHGSTSPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSSQPNLSTSHSEQEYGKAGGSPASYHGSTSPR 33 1 F6PQP6;I3L2B2;O95208-3;O95208-2 F6PQP6 EPN2 Epsin-2 1 56342000.0 19628000.0 18384000.0 18330000.0 True False 29777110.9990105 15103231.565152397 14707067.465675596 1.0 0.5072094322936258 0.493905116119704 24.827700453404113 GSSQPNLSTSHSEQEYGK(ub)AGGSPASYHGSTSPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSSQPNLSTSHSEQEYGKAGGSPASYHGSTSPR 33 1 F6PQP6;I3L2B2;O95208-3;O95208-2 F6PQP6 EPN2 Epsin-2 1 32874000.0 10228000.0 16911000.0 5735000.0 True False 8505035.177226683 16819897.086429324 6934161.9843560085 1.0 1.9776399198755514 0.8153008000393828 23.019885772279917 -6.6836653578569 1.8887763800666815 1.616519400096872 0.819584635872273 0.3409826610721295 0.41401968761028807 0.43045240118378497 2.972026734683232 0.17568313741319452 0.46120297376790387 2.0717370943828698e-07 6.6836653578569 -0.7969347642245989 GSSQPNLSTSHSEQEYGK(ub)AGGSPASYHGSTSPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSSQPNLSTSHSEQEYGKAGGSPASYHGSTSPR 33 1 F6PQP6;I3L2B2;O95208-3;O95208-2 F6PQP6 EPN2 Epsin-2 1 55495000.0 19628000.0 22424000.0 13443000.0 True False 25408832.925723016 21176084.6877198 10996511.936828112 1.0 0.8334142992566128 0.43278303922789096 24.598826775496562 -6.956286943747653 0.48494090063897044 1.0091831087065302 0.24017070341991062 0.9996067342083482 0.004720661743638478 0.08105517552332957 0.026242540268675382 0.005706610022346903 0.03304435738834673 1.1058928654160907e-07 6.956286943747653 -0.7690124052866195 down GSSSASIVK(ub)GQHEMSEMDGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSSSASIVKGQHEMSEMDGR 20 1 Q14126 Q14126 DSG2 Desmoglein-2 1 9235000.0 2061400.0 2067500.0 5106100.0 True False 1995961.9853533108 2893063.531870064 3768659.230283473 1.0 1.4494582327217793 1.8881417872376824 20.928652813013112 -6.9714228390711455 0.22158478690476902 0.8017035737953235 2.5483065376048173 0.9999914541145744 0.0010599598681960982 0.07584366283755598 0.007355919493166728 0.012005102786776325 0.04431479735043803 1.0680145294024466e-07 6.9714228390711455 1.7466029638094938 GSSSASIVK(ub)GQHEMSEMDGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSSSASIVKGQHEMSEMDGR 20 1 Q14126 Q14126 DSG2 Desmoglein-2 1 12130200.0 0.0 4162400.0 7967800.0 True False 0.0 3419587.19902036 6392960.837589206 0.0 GSSSASIVK(ub)GQHEMSEMDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSSSASIVKGQHEMSEMDGR 20 1 Q14126 Q14126 DSG2 Desmoglein-2 1 5960400.0 2485900.0 1756400.0 1718100.0 True False 3405004.4089215216 1678796.44036191 1312320.1653802127 1.0 0.49303796375806774 0.3854092411574493 21.69922523561588 -13.999999999999998 0.21781339580139664 4.0302294530902225 0.3266181608713457 0.9994957985699312 0.006017320159899521 12.941045271723599 0.14786623965511247 16.847738136963766 0.060435191919405135 1.0000000000000041e-14 13.999999999999998 -3.7036112922188766 GSSSASIVK(ub)GQHEMSEMDGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSSSASIVKGQHEMSEMDGR 20 1 Q14126 Q14126 DSG2 Desmoglein-2 1 8241600.0 2061400.0 2884800.0 3295400.0 True False 1714145.4355040158 2869259.009812032 3984452.9037919464 1.0 1.673871394096951 2.3244544023304443 20.70905808844739 -6.971554629353003 0.21787868428014526 0.6918263159660567 3.3248250297590696 0.9999921017047161 0.0015196630802771123 0.07580142062007252 0.007197328876993027 0.01831683247854347 0.06623963109127545 1.0676904806580939e-07 6.971554629353003 2.632998713793013 GSSSASIVK(ub)GQHEMSEMDGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSSSASIVKGQHEMSEMDGR 20 1 Q14126 Q14126 DSG2 Desmoglein-2 1 17745200.0 0.0 4961200.0 12784000.0 True False 0.0 4685104.858754704 10457443.174917094 0.0 GSSSSESQK(ub)PCEALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSSSSESQKPCEALR 15 1 Q96RR4-6;Q96RR4-5;Q96RR4-2;Q96RR4-3;Q96RR4-4;Q96RR4-7;Q96RR4;F5H360;F5H4I7 Q96RR4-6 CAMKK2 Calcium/calmodulin-dependent protein kinase kinase 2 1 11457800.0 1244700.0 1796800.0 8416300.0 True False 1611288.6867050838 1696806.5004858607 6884619.758530568 1.0 1.0530741725467283 4.272741325211494 20.619783567133776 -6.91048122552058 0.8924602985169281 0.9018237805408997 4.693128031926314 0.9911017035228227 0.144366540323674 0.10410040991955254 0.13705083198999773 0.1184767988135457 0.32814650163777204 1.228906310849041e-07 6.91048122552058 3.791304251385414 up GSSYK(ub)LLVEQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSSYKLLVEQAK 12 1 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 1 165457000.0 51473000.0 78914000.0 35070000.0 True False 67481601.46524113 67140338.8043628 31441292.8151943 1.0 0.9949428784517791 0.4659239278929871 26.007990876108295 -6.908991998389131 0.9025717519971345 1.0169062376735343 0.39901090248550475 0.9905355805624109 0.02437797068648434 0.10508838593028971 0.14241084844736004 0.019859624749650043 0.054446141053041325 1.2331275526424482e-07 6.908991998389131 -0.6178953351880295 down GSSYK(ub)LLVEQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSSYKLLVEQAK 12 1 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 1 117233000.0 22945000.0 59028000.0 35260000.0 True False 22216623.534458008 82598188.22695348 26024348.22267396 1.0 3.7178551501691333 1.1713907913284018 24.405136237903626 -6.630770037935052 2.077439087661799 2.7895158124384265 1.1816137269192424 0.1203866413108804 1.1655778991132686 0.5569684843230285 4.581668774818948 0.4587066814145826 1.2913156335045302 2.3400759978069694e-07 6.630770037935052 -1.6079020855191841 GSSYK(ub)LLVEQAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSSYKLLVEQAK 12 1 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 1 82026000.0 29273000.0 21975000.0 30778000.0 True False 44409281.14296079 18053389.558541328 24694714.809523374 1.0 0.4065228955277275 0.5560710323147772 25.404357882670823 -10.327695132026415 8.689756713499456 1.0000007460244338 0.48129696392158045 0.9413158177831681 0.06105277118536896 8.824324139707223e-07 6.822127507406e-08 0.059114176941256605 0.019704697170062176 4.70224082768033e-11 10.327695132026415 -0.5187037821028533 GSSYK(ub)LLVEQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSSYKLLVEQAK 12 1 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 1 110267400.0 51473000.0 51708000.0 7086400.0 True False 70503959.10552216 49423369.584510095 5412738.268989192 1.0 0.7010013368261905 0.07677211801521718 26.071200937631186 -7.365729258192129 0.6266826634518213 0.9989770848570426 7.503174390709518e-21 0.9949213909969804 0.02740989455566385 0.10636951859071131 0.08560126906827664 0.02548062998394205 0.06561981154908174 4.3079508706200916e-08 7.365729258192129 -0.9989770848570426 down GSSYK(ub)LLVEQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSSYKLLVEQAK 12 1 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 1 128152000.0 22945000.0 93603000.0 11604000.0 True False 19079784.13584926 93098742.06025921 14030342.749166034 1.0 4.879444201118331 0.7353512308770955 24.185541513337903 -6.661017980653958 1.9691126562175367 3.495041504361472 0.7525422864484475 0.23999332974316834 1.6513757347188067 0.4820458520055708 3.5940608751877297 0.6772733268104923 1.831033256511172 2.1826395443609687e-07 6.661017980653958 -2.742499217913025 GSTAPVGGGAFPTIVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSTAPVGGGAFPTIVER 17 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 57044200.0 2097200.0 26209000.0 28738000.0 False True 2749449.509313692 22298719.361881856 25764467.434361435 1.0 8.110248719369277 9.370773075513823 21.390711362621953 -9.374599717708687 0.554183113975042 5.754475650614341e-23 9.299131379104427 0.9982046183219915 0.15614149385926296 0.7248126743972814 0.24023828167075678 1.9235618162072186 0.23211617463047085 4.2208535353517767e-10 9.374599717708687 9.299131379104427 GSTAPVGGGAFPTIVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSTAPVGGGAFPTIVER 17 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 49846800.0 15324000.0 6200800.0 28322000.0 False True 14837548.007933509 8676811.776744818 20903618.558212463 1.0 0.5847874441319686 1.4088324126759677 23.82274936202787 -6.769732291873588 1.575595026057178 0.761759136892919 1.4134063294595078 0.7294735910471004 0.17497840741267084 0.26687364549366305 1.3074720096948003 0.08754070043281952 0.20842451667535375 1.6992908077836204e-07 6.769732291873588 0.6516471925665889 GSTAPVGGGAFPTIVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSTAPVGGGAFPTIVER 17 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 50926200.0 2097200.0 28499000.0 20330000.0 False True 2872591.5146989883 27239819.94640972 15528472.709492886 1.0 9.482663931514159 5.405736468284484 21.453921424144845 -9.736264491842979 9.163530681183758 1.000000000023772 7.4442001998993454 0.7691212366826823 1.6643986672086888 0.0 0.0 1.6115470798872678 0.5371823599624225 1.8354202045115464e-10 9.736264491842979 6.444200199875573 GSTDDKGPVAGWINALEAYQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSTDDKGPVAGWINALEAYQK 21 1 Q96KP4;J3QKT2;A0A087WYZ1;J3KSV5;J3QRH4;A0A087WVS2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 6679000.0 2778500.0 1209500.0 2691000.0 False True 2690298.038374008 1692459.6574591773 1986146.3717304463 1.0 0.6290974580950461 0.7382625803536828 21.35933457655448 -10.420330782056746 8.7258929111904 1.0000027669104645 0.683680019224365 0.9179991923971611 0.044566474540366996 2.398921943736388e-06 1.5935579883050643e-07 0.04315168105715678 0.014383767807834843 3.7989993385871825e-11 10.420330782056746 -0.31632274768609947 GSTGFGQDSILSLPGNVGHQDVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSTGFGQDSILSLPGNVGHQDVK 23 0 C9JIF9;P13798 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 13111800.0 1936700.0 5947700.0 5227400.0 False True 2539032.4550294797 5060326.34395302 4686518.792761529 1.0 1.9930136512942944 1.8457892428583058 21.27584740558995 -10.174780686077751 4.807617833817744 0.9999008789176909 1.9194014470801195 0.981131483772471 0.06010411307169702 42147424.18803586 8.65142580261035 46246.92245601815 0.02057523657814766 6.686815091066812e-11 10.174780686077751 0.9195005681624286 GSTLDLSDLEAEK(ub)LVMFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSTLDLSDLEAEKLVMFQR 19 1 O00767 O00767 SCD Acyl-CoA desaturase 1 97883000.0 8753700.0 8313300.0 80816000.0 True False 8475818.585033126 11632844.04328679 59647865.17196877 1.0 1.372474401921301 7.037416454063433 23.014921278167574 -6.920256999893206 0.8228175818632262 0.8761605764132305 7.95636399706949 0.9942520116446035 0.20943730995523943 0.0980208886852938 0.10483222919512862 0.18069742652658968 0.542612349185582 1.2015531881244856e-07 6.920256999893206 7.080203420656259 up GSTLDLSDLEAEK(ub)LVMFQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSTLDLSDLEAEKLVMFQR 19 1 O00767 O00767 SCD Acyl-CoA desaturase 1 86555100.0 8753700.0 9486400.0 68315000.0 True False 7279089.404662613 9435294.88029703 82599350.64712831 1.0 1.2962191224431536 11.347484012796901 22.79532655360185 -6.913196350356854 0.8736758842386254 0.7193626752855159 12.739370476496997 0.9920731082016478 0.4282092771084193 0.10234238627542407 0.127579527496741 0.35621789821728556 1.0065382030867964 1.2212473930137567e-07 6.913196350356854 12.02000780121148 up GSTNAK(ub)ELSSK(ub)GVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSTNAKELSSKGVK 14 2 P04818;P04818-2 P04818 TYMS Thymidylate synthase 2 7062400.0 2644300.0 2563100.0 1855000.0 True False 2560358.143916642 3586559.196389927 1369119.8511928578 1.0 1.400803713695882 0.534737632094892 21.287914198421795 -6.780860993365288 1.5324877540621917 1.2266886763754388 0.5276865960781771 0.770445939982995 0.16955807501471523 0.24923231209104485 1.1561822099856234 0.08713908187115824 0.20546658576500879 1.6563000182104202e-07 6.780860993365288 -0.6990020802972616 GSTNAK(ub)ELSSK(ub)GVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSTNAKELSSKGVK 14 2 P04818;P04818-2 P04818 TYMS Thymidylate synthase 2 6830130.0 2644300.0 3241500.0 944330.0 True False 2198852.6123524173 3224037.396112624 1141785.0369114056 1.0 1.4662362443035346 0.5192640154675396 21.06831947385607 -6.7728363205724404 1.5635482811146626 1.2664581805934874 0.5133552018458842 0.7412663333591747 0.1966550296590545 0.2618908415996659 1.263902187551612 0.09911415791639139 0.23532901814885596 1.6871887830882043e-07 6.7728363205724404 -0.7531029787476031 GSTNAK(ub)ELSSK(ub)GVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSTNAKELSSKGVK 14 2 P04818;P04818-2 P04818 TYMS Thymidylate synthase 2 15829200.0 3013500.0 4394100.0 8421600.0 True False 3901035.1549656754 4149564.472275669 6888955.212913155 1.0 1.0637085561747983 1.7659300517054093 21.895425568882782 -6.924656044375994 0.7894168986253497 0.9869481163834181 1.8922591705547458 0.9953798057550712 0.023587828512451007 0.09550890035083534 0.09197820219467771 0.020841806862811812 0.06550464309744784 1.1894438786991432e-07 6.924656044375994 0.9053110541713277 GSTNLGVNQAGFTLHSAIYAARPDVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSTNLGVNQAGFTLHSAIYAARPDVK 26 1 E7EV99;E7ENY0;P35611-2;P35611-6;P35611;P35611-3;P35611-4;A0A0A0MSR2;P35611-5;D6RF25 E7EV99 ADD1 Alpha-adducin 0 34696200.0 6549000.0 8758200.0 19389000.0 False True 8477809.600089664 8270798.470923446 15860400.94794022 1.0 0.9755820030254008 1.8708135351108233 23.01526013514028 -6.900629605296248 0.9572712389559302 0.9634188978184642 1.9659963617112428 0.9868769204763608 0.047698849737448146 0.11094419922234497 0.17481525211770607 0.03732610798021212 0.09742737949108052 1.257101645031005e-07 6.900629605296248 1.0025774638927785 GSTSAYTK(ub)SGYCVNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSTSAYTKSGYCVNR 15 1 H3BUB4;O95149;H3BRI5 H3BUB4 SNUPN Snurportin-1 1 11945400.0 1728900.0 2082900.0 8133600.0 True False 2622867.699520539 1711190.2212280226 6525990.3949164795 1.0 0.6524119464892677 2.4881126852526463 21.32271360755636 -6.8577024441880505 1.1972600288157986 0.8124420560042619 2.573196526024425 0.9507891890637028 0.17662021495233426 0.14918791481165705 0.40766664682037995 0.11515976553662034 0.2681651596543702 1.3877062868326351e-07 6.8577024441880505 1.7607544700201632 up GSTSAYTK(ub)SGYCVNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSTSAYTKSGYCVNR 15 1 H3BUB4;O95149;H3BRI5 H3BUB4 SNUPN Snurportin-1 1 3611200.0 1728900.0 1882300.0 0.0 True False 2238095.1317140018 1777548.3503253195 0.0 1.0 0.7942237687474967 0.0 21.09383992964881 -7.259802175892694 0.8459890677176989 0.9891550422660622 4.97158766556379e-17 0.9887139771590474 0.045805194241637426 0.09950244866248098 0.13792847197677266 0.03885998690215407 0.06848801226766872 5.497912505046195e-08 7.259802175892694 -0.9891550422660622 down GSTSK(ub)EGEPNLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSTSKEGEPNLDK 13 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 5824490.0 1455600.0 604090.0 3764800.0 True False 1908305.6960504511 513962.1267243766 3375254.6105116503 1.0 0.2693290324438609 1.7687179876354655 20.863860867947263 -6.774219769694978 1.5585546566414945 0.5831664488179391 1.7784809162887063 0.7463518005733827 0.308319629518942 0.2596588443435945 1.2453518218250683 0.15588581951588956 0.36961690024938676 1.681822778750204e-07 6.774219769694978 1.1953144674707672 GSTSK(ub)EGEPNLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSTSKEGEPNLDK 13 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 7896200.0 1455600.0 1722800.0 4717800.0 True False 1993774.6561109305 1646680.999462249 3603552.80614095 1.0 0.8259112906341559 1.8074022533569882 20.927070929470155 -6.861063663630244 1.1802423242619737 0.9052569562397214 1.8559297280838152 0.9549270563762212 0.09077987481968669 0.14571596650825047 0.38507796823025203 0.059961383838476476 0.14014965411007668 1.3770075972792883e-07 6.861063663630244 0.9506727718440938 GSTSK(ub)EGEPNLDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSTSKEGEPNLDKK 14 2 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 27926200.0 5913500.0 7880700.0 14132000.0 True False 7752655.766415453 6704930.278728004 12669756.20371619 1.0 0.86485592560085 1.634247229007851 22.88625917709242 -6.861547300607993 1.1777992401227215 0.9263465252685656 1.6726377471910898 0.9554993849375888 0.07075522306095282 0.1452215637687163 0.3819091007642319 0.046822391529232885 0.10950175406628711 1.3754749940806653e-07 6.861547300607993 0.7462912219225242 GSTSK(ub)EGEPNLDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSTSKEGEPNLDKK 14 2 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 34913900.0 6640700.0 7353200.0 20920000.0 True False 6429894.613435406 10289371.10643143 15440424.413452601 1.0 1.6002394634791623 2.4013495308600383 22.616363661166652 -6.967125350798154 0.31947911237278304 0.889615396187446 3.13779321562679 0.9999504918957243 0.004039156629146259 0.0772469467637404 0.012354764095160644 0.012168987962474192 0.07050002498267957 1.0786353498267615e-07 6.967125350798154 2.248177819439344 GSTSK(ub)EGEPNLDKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSTSKEGEPNLDKK 14 2 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 33784200.0 7166800.0 6842400.0 19775000.0 True False 10872559.563262083 5621320.260084796 15866462.582309581 1.0 0.5170190356168752 1.4593125464147085 23.374188276567203 -6.767395075332602 1.5845984240072832 0.7220532878206181 1.4640781102756646 0.7204411185736306 0.2034196411730718 0.27065888380798375 1.3408576963537453 0.10121489403911305 0.241496850174011 1.708460430783173e-07 6.767395075332602 0.7420248224550465 GSTSK(ub)EGEPNLDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSTSKEGEPNLDKK 14 2 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 32306500.0 5913500.0 7866000.0 18527000.0 True False 8099880.756328645 7518454.110616478 14151304.175542267 1.0 0.9282178758918292 1.7471003094070847 22.94946923861531 -6.885539878585111 1.0483726650354386 0.951182233249803 1.8116807260483967 0.9778879397235386 0.05505918867873291 0.12283800311212956 0.24356713667749078 0.04023143385921967 0.09881827267453215 1.3015477969810768e-07 6.885539878585111 0.8604984927985937 GSTSK(ub)EGEPNLDKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSTSKEGEPNLDKK 14 2 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 31227700.0 6640700.0 11139000.0 13448000.0 True False 5522036.282891012 11078991.996081607 16259914.623473337 1.0 2.0063236510067446 2.944550486539108 22.396768936600928 -6.971968798328903 0.2057994856876707 0.48167822306842006 4.495265237347608 0.9999939396585885 0.0019546949787641738 0.07566890162578696 0.00669314263199199 0.029055751792060706 0.09819048479943918 1.0666727530509715e-07 6.971968798328903 4.013587014279188 GSTSK(ub)EGEPNLDKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSTSKEGEPNLDKK 14 2 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 24678400.0 7166800.0 5788600.0 11723000.0 True False 9277563.878748292 5466459.321411645 9589534.288137754 1.0 0.589212792588087 1.0336263283623495 23.145314598659652 -11.95294201440049 17.914885309732714 0.897566806594914 0.8302776044687842 0.0 0.20677575501097142 0.0 0.0 0.0 0.06016169224264089 1.1144433205390846e-12 11.95294201440049 -0.06728920212612977 GSVLLFPSRPGLLK(ub)DPGVGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSVLLFPSRPGLLKDPGVGGK 21 2 E9PDU5;A0A087X295;Q9NNW5 E9PDU5 WDR6 WD repeat-containing protein 6 1 16095400.0 6409800.0 7350400.0 2335200.0 True False 6206324.407547129 10285453.05182963 1723541.0655016492 1.0 1.6572535330770213 0.2777072148219898 22.565307678522004 -6.7771468170561215 1.546864368603261 1.3735398406341408 0.26772207553780514 0.7571759633374843 0.2776305940889959 0.2550499274692648 1.2051905700255594 0.14138702118163343 0.3344355298261001 1.6705257829602005e-07 6.7771468170561215 -1.1058177650963357 GSVLLFPSRPGLLK(ub)DPGVGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSVLLFPSRPGLLKDPGVGGK 21 2 E9PDU5;A0A087X295;Q9NNW5 E9PDU5 WDR6 WD repeat-containing protein 6 1 16708200.0 6409800.0 8480600.0 1817800.0 True False 5330032.702286622 8434913.3245327 2197893.575442437 1.0 1.5825256233257374 0.41236024208623057 22.34571295395628 -6.771349444887772 1.569311238683671 1.333542198857016 0.4054427389613416 0.7357004798299017 0.24559594400323828 0.26424604356186476 1.2845037786025024 0.12334350120003527 0.29324399810169766 1.6929750395320097e-07 6.771349444887772 -0.9280994598956744 down GSVSDEEMMELR ddPTM_RPMI8226_Bortezomib_1h_R1 2 GSVSDEEMMELR 12 0 P13796;Q5TBN3;Q5TBN5 P13796 LCP1 Plastin-2 0 45256200.0 7655000.0 20272200.0 17329000.0 False True 10035779.131125448 17247666.78041667 15535961.311505634 1.0 1.718617613546708 1.5480573165786058 23.25864928938011 -10.067217363532771 4.511248823477171 0.9999625741536152 1.633337464992194 0.9484125469102817 0.06963094978816707 10759928.970294993 12005828.467045946 3373.194814328924 0.023836526908725033 8.566090068022685e-11 10.067217363532771 0.6333748908385787 GSVSDEEMMELR ddPTM_RPMI8226_Bortezomib_2h_R1 2 GSVSDEEMMELR 12 0 P13796;Q5TBN3;Q5TBN5 P13796 LCP1 Plastin-2 0 38018050.0 11144500.0 3678950.0 23194600.0 False True 10790723.947690886 5147973.920470805 17119238.436915286 1.0 0.4770740077705744 1.5864772854817255 23.363288322430165 -6.778505929358437 1.5414871335199394 0.7033358610768006 1.5948914095494666 0.7621485354336528 0.22100603139777678 0.25289528985117277 1.1868085151377257 0.11293031575444817 0.26682559211599144 1.6653060914516338e-07 6.778505929358437 0.891555548472666 GSVSDEEMMELR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GSVSDEEMMELR 12 0 P13796;Q5TBN3;Q5TBN5 P13796 LCP1 Plastin-2 0 38031400.0 7655000.0 14820100.0 15556300.0 False True 10485260.368596572 14165298.978483003 11882222.332055286 1.0 1.3509725539013004 1.1332310228215814 23.321859350903 -10.21044869706476 4.281351407750482 0.9998995991902804 1.242101788339596 0.6224078932293516 0.08889260786064129 8.560112457417276e-05 1.5786102602685263e-05 0.08610566069874126 0.028689965815653997 6.159582875846673e-11 10.21044869706476 0.24220218914931557 GSVSDEEMMELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSVSDEEMMELR 12 0 P13796;Q5TBN3;Q5TBN5 P13796 LCP1 Plastin-2 0 12863800.0 8075800.0 2310500.0 2477500.0 False True 6715385.518600631 2298052.8779016556 2995533.7953342698 1.0 0.342207140831511 0.44607026462398647 22.67903879396694 -10.52272354607548 6.650528074068813 1.0004057259207528 0.39413870272774876 0.978434022052936 0.04240194273051469 0.00025524097080001725 1.8317307917041614e-05 0.04108140552273623 0.01368516817017701 3.001072269708048e-11 10.52272354607548 -0.6062670231930041 GSYCHFVLYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSYCHFVLYK 10 0 Q96PZ0;Q96PZ0-2;E7EUH7;H0Y863 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 34811700.0 11191000.0 9738700.0 13882000.0 False True 14671509.373798152 8285723.921155277 12445623.805546837 1.0 0.564749250404512 0.8482851687893459 23.806513964267005 -10.457920784935364 6.850190906499038 1.0000567853791684 0.7065172095969292 0.5882274237754701 0.11575305396570984 0.00010040542866064417 7.945495364651712e-06 0.11209900713249407 0.037359137523486886 3.4840085735753215e-11 10.457920784935364 -0.2935395757822392 GSYCHFVLYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSYCHFVLYK 10 0 Q96PZ0;Q96PZ0-2;E7EUH7;H0Y863 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 11794700.0 5399000.0 1761100.0 4634600.0 False True 5227611.700263188 2464316.4140151776 3420659.224980281 1.0 0.47140387528995503 0.6543445498846185 22.31772055305325 -10.210260607617096 5.545700955442905 1.0000024710640227 0.5628742127099157 0.8838905752082256 0.0746852182143076 1.6839997865775428e-05 2.3983121178687418e-06 0.07231666354476592 0.02410455044577261 6.162251119412631e-11 10.210260607617096 -0.43712825835410707 GSYCHFVLYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSYCHFVLYK 10 0 Q96PZ0;Q96PZ0-2;E7EUH7;H0Y863 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 41407200.0 11191000.0 8995200.0 21221000.0 False True 15328615.125403553 8597762.320851417 16209036.860213876 1.0 0.5608962225558564 1.0574364825268026 23.869724025789896 -6.673267785962318 1.9255163452081556 0.7205185374318037 1.0554731953022936 0.293724076582502 0.18638145937481806 0.45365529904016993 3.24565703343144 0.07783510310575534 0.20709441187268024 2.1219356730804428e-07 6.673267785962318 0.33495465787048984 GSYCHFVLYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSYCHFVLYK 10 0 Q96PZ0;Q96PZ0-2;E7EUH7;H0Y863 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 10352590.0 5399000.0 897990.0 4055600.0 False True 4489507.716254095 893152.3496329399 4903607.209024281 1.0 0.19894215715440589 1.0922371714098975 22.098125828487525 -6.670320701780501 1.9360731035801826 0.4888350213968976 1.0886446872935023 0.28054117426451963 0.3402456584147285 0.46037953480500504 3.3272048353474077 0.14145970194201332 0.3778093173723733 2.1363839088356893e-07 6.670320701780501 0.5998096658966047 GSYCHFVLYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSYCHFVLYK 10 0 Q96PZ0;Q96PZ0-2;E7EUH7;H0Y863 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 25866800.0 5836700.0 11537000.0 8493100.0 False True 7555723.20855753 10894955.808161948 6947442.946565107 1.0 1.4419474492954478 0.9194941046406396 22.84913842126808 -6.6825056439148325 1.8929673957394115 1.278994398401321 0.9214415620189441 0.33562694135319426 0.18720614251192688 0.4329863463790019 3.00184628081188 0.0792921022391529 0.2084600191390702 2.0772767299518125e-07 6.6825056439148325 -0.3575528363823769 GSYGDLGGPIITTQVTIPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSYGDLGGPIITTQVTIPK 19 0 P61978;P61978-2;S4R359;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 309909000.0 74369000.0 132380000.0 103160000.0 False True 97498479.19042045 112629420.01319848 92485992.78059451 1.0 1.1551915573290779 0.948589081066216 26.53887637967327 -6.705731954638476 1.8105869537147115 1.0958239508602439 0.9491369243376744 0.4446994450629447 0.06544256967001684 0.3837388449203631 2.449495694519192 0.028793961369624355 0.07352667878991169 1.9691012386134257e-07 6.705731954638476 -0.14668702652256949 GSYGDLGGPIITTQVTIPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSYGDLGGPIITTQVTIPK 19 0 P61978;P61978-2;S4R359;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 380033000.0 111740000.0 93503000.0 174790000.0 False True 108192874.86338352 130839235.51170358 129007255.41239876 1.0 1.2093147139025182 1.192382174660742 26.68903025144538 -10.077581998853761 4.658824773360329 0.9999898729156768 1.200848444286646 0.9946977531508244 0.0069126802158356124 7.271633424702744e-07 1.439832333036219e-07 0.006693511273821594 0.00223105794370543 8.364076592696313e-11 10.077581998853761 0.2008585713709693 GSYGDLGGPIITTQVTIPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSYGDLGGPIITTQVTIPK 19 0 P61978;P61978-2;S4R359;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 956260000.0 190530000.0 516800000.0 248930000.0 False True 289047939.60879683 424573002.2231701 199728876.39010516 1.0 1.4688670771976287 0.6909887566070256 28.106733547673148 -6.74350361125743 1.673704177213259 1.2778442111395723 0.6901642613317649 0.6205517512363069 0.19699164243216757 0.3115561828161084 1.7149139369096091 0.09305779202151783 0.227497717254765 1.8050797274205295e-07 6.74350361125743 -0.5876799498078074 GSYGDLGGPIITTQVTIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSYGDLGGPIITTQVTIPK 19 0 P61978;P61978-2;S4R359;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 317624000.0 74369000.0 91755000.0 151500000.0 False True 101865229.0466569 87700960.7067905 115718820.2404412 1.0 0.8609509007889355 1.135999215075038 26.60208644119616 -6.769263254756426 1.5772160474978927 0.9201694822919644 1.1375051367530622 0.7277413786512197 0.058591292844949426 0.267630249215106 1.3137801272824405 0.02928296107865813 0.06975445659761027 1.701127029622759e-07 6.769263254756426 0.21733565446109782 GSYGDLGGPIITTQVTIPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSYGDLGGPIITTQVTIPK 19 0 P61978;P61978-2;S4R359;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 277021000.0 111740000.0 84761000.0 80520000.0 False True 92916760.92132463 84304375.6692588 97356359.71758442 1.0 0.9073107460196747 1.0477803870070217 26.469435526879657 -6.7287241072690325 1.7276475664080608 0.9441421361732324 1.047681317734381 0.5534591530296888 0.03896839389620843 0.33862797472677886 1.9794685970981185 0.01787799999344273 0.044431249041577796 1.867565715990243e-07 6.7287241072690325 0.1035391815611485 GSYGDLGGPIITTQVTIPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSYGDLGGPIITTQVTIPK 19 0 P61978;P61978-2;S4R359;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 614870000.0 190530000.0 250750000.0 173590000.0 False True 246644840.90778488 236795542.07303515 141998401.18381235 1.0 0.960066876734583 0.5757201353216321 27.877859869765597 -6.926828209931839 0.7723878882549775 1.0065834238236997 0.5028332055579557 0.9958771795872001 0.012282644070892938 0.09431872849121878 0.0859974804046371 0.010985710737531254 0.03540269459102829 1.1835096136885291e-07 6.926828209931839 -0.503750218265744 GSYLLPGMASFVTSNKPDLQVTIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSYLLPGMASFVTSNKPDLQVTIK 24 1 P14316-2;P14316 P14316-2 IRF2 Interferon regulatory factor 2 0 27949700.0 8212900.0 9689800.0 10047000.0 False True 12459569.743416185 7960579.483247043 8061206.046243469 1.0 0.6389128715663337 0.6469891185851844 23.570750913973352 -10.223933600513613 5.4159565200609405 1.0000223658779566 0.6429509950757217 0.9996164168613251 0.003297114038941147 8.904816436661964e-07 1.2759541585140316e-07 0.00319261668336818 0.0010641389802614465 5.971265745662925e-11 10.223933600513613 -0.35707137080223483 GSYSIK(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSYSIKSR 8 1 P52565;J3KRE2 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 1 4727220.0 895220.0 2219100.0 1612900.0 True False 1173642.0893228108 1888018.9299840492 1446012.580029284 1.0 1.608683726632054 1.2320728722873517 20.162561084514635 -10.138917491979281 4.331995262399659 0.9999355893551893 1.4203782993275855 0.6242360027658125 0.15375073775671144 22671084.122266036 26530543.389560107 13577.242787724865 0.05263296770042293 7.262439174118494e-11 10.138917491979281 0.4204427099723962 GSYSIK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSYSIKSR 8 1 P52565;J3KRE2 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 1 3887200.0 1256200.0 2631000.0 0.0 True False 1216322.6186091157 3681572.0204837443 0.0 1.0 3.0268055235984024 0.0 20.21409451071677 -6.726263551399116 1.7367803937133284 2.2247900995348298 0.0029974321991500645 0.541833202984322 0.8523045612216947 0.3433207701842972 2.0270250947357744 0.38916439889311416 0.9698240585650767 1.8781767002642996e-07 6.726263551399116 -2.22179266733568 GSYSIK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSYSIKSR 8 1 P52565;J3KRE2 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 1 4631260.0 1256200.0 2496100.0 878960.0 True False 1044585.9590958311 2482653.0138629405 1062746.472148137 1.0 2.376686181012682 1.0173853696712765 19.994499786151046 -6.643213320006572 2.0326339743390665 1.8980618347327902 1.023043612808563 0.16710901525519772 0.5885700494605759 0.5253244798877931 4.151949152530814 0.2354694818260278 0.6518568795913069 2.2739802058333923e-07 6.643213320006572 -0.8750182219242273 GSYTAQFEHTILLRPTCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSYTAQFEHTILLRPTCK 18 1 P50579;F8VQZ7;P50579-3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 0 81034800.0 21355800.0 33574000.0 26105000.0 False True 27997660.609861366 28564890.070426986 23403905.016841967 1.0 1.0202598877266849 0.835923591723182 24.73880294968354 -6.879644544214715 1.0817447052475389 1.0124996275469758 0.822946687073692 0.9733991135267184 0.013461621666071547 0.1279470020673359 0.27417320965773223 0.009588983603065822 0.02316849660651739 1.3193361301111283e-07 6.879644544214715 -0.18955294047328375 GSYTAQFEHTILLRPTCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSYTAQFEHTILLRPTCK 18 1 P50579;F8VQZ7;P50579-3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 0 45397200.0 16236000.0 7967100.0 21194100.0 False True 15720597.067137064 11148404.577877643 15642729.400628852 1.0 0.7091591070152604 0.9950467742302873 23.906152676301684 -10.815673454395089 9.601084767913232 1.0025131863966632 0.8521029406636919 0.26299049864309143 0.11671315140523651 0.006365792787956926 0.00012221349845796967 0.114575300056035 0.03766900763965547 1.528715065608569e-11 10.815673454395089 -0.15041024573297135 GSYTAQFEHTILLRPTCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSYTAQFEHTILLRPTCK 18 1 P50579;F8VQZ7;P50579-3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 0 132054000.0 31552000.0 51887000.0 48615000.0 False True 47866690.76017818 42627359.45501867 39006223.94128855 1.0 0.8905432729534276 0.8148928476530295 25.512518733713794 -6.9750655484995105 0.06322001456107536 1.372134018385453 0.33141743059012807 0.9999999560651395 1.4844472564167008e-05 0.07469094797949286 0.0018193014666224678 0.012150080356206763 0.017722127222623667 1.0590938630199619e-07 6.9750655484995105 -1.0407165877953248 GSYTAQFEHTILLRPTCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSYTAQFEHTILLRPTCK 18 1 P50579;F8VQZ7;P50579-3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 0 62027800.0 21355800.0 24349000.0 16323000.0 False True 29251616.37879485 23273180.668624524 12467843.582737437 1.0 0.7956203297365739 0.4262275089788083 24.80201301120643 -6.961976156879342 0.40662975980155913 1.0188791586082717 0.18933517821252552 0.9998366057393081 0.0030352007030383845 0.07900266503999724 0.018577893038996075 0.004753262762054549 0.03087602283961526 1.0915002590567597e-07 6.961976156879342 -0.8295439803957462 down GSYTAQFEHTILLRPTCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSYTAQFEHTILLRPTCK 18 1 P50579;F8VQZ7;P50579-3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 0 32042900.0 16236000.0 4797600.0 11009300.0 False True 13500953.376755212 4771754.376550956 13311293.728748143 1.0 0.35343832716040297 0.9859521292523231 23.68655795173596 -10.821235614300928 10.184255268101444 1.0049926682703225 0.669695228206363 0.2666491566368526 0.25822267839882457 0.029313304829254455 0.0005145358566827277 0.2503723169499866 0.0833410110876434 1.509261124684298e-11 10.821235614300928 -0.33529744006395956 GSYTAQFEHTILLRPTCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSYTAQFEHTILLRPTCK 18 1 P50579;F8VQZ7;P50579-3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 0 135095000.0 31552000.0 0.0 103543000.0 False True 40844685.982902534 0.0 84699236.44089808 1.0 0.0 2.073690479009997 25.283645055806243 -6.775559815932213 1.5529986653144023 0.4305137824627973 2.0879369544791815 0.751428855962899 0.42216774564718373 0.2575323302629706 1.226441251386172 0.21417172256422032 0.5072991345418169 1.6766413938900516e-07 6.775559815932213 1.6574231720163841 GSYVSIHSSGFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GSYVSIHSSGFR 12 0 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8;Q13838-2;Q13838;Q5STU3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;F6R6M7;A0A0G2JHN7;F6SXL5;F6S2B7;F6U6E2;F6QYI9;A0A0G2JJL7 O00148;Q13838-2;F6QYI9 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 873080000.0 158550000.0 227120000.0 487410000.0 False True 207860585.4003843 193234581.30682585 436977488.76686263 1.0 0.9296355099482395 2.102262379013076 27.631040978871525 -6.892637430708592 1.006633082771402 0.940919196396037 2.208495698135097 0.9825339819822653 0.0709648539208054 0.1170299785730092 0.20954845555504534 0.053519917555381886 0.1347596051680597 1.2804498373163103e-07 6.892637430708592 1.26757650173906 up GSYVSIHSSGFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GSYVSIHSSGFR 12 0 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8;Q13838-2;Q13838;Q5STU3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;F6R6M7;A0A0G2JHN7;F6SXL5;F6S2B7;F6U6E2;F6QYI9;A0A0G2JJL7 O00148;Q13838-2;F6QYI9 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 638303000.0 109960000.0 71063000.0 457280000.0 False True 106469379.98906092 99438826.48864934 337504649.89405364 1.0 0.9339664277078167 3.1699691491462634 26.665863338004307 -6.900096552972689 0.9606749265580002 0.9072813072530002 3.405121384378218 0.9866137780494683 0.12019343710911236 0.11133365719670701 0.17702695432432333 0.09382052225082359 0.24421868935661967 1.25864555679934e-07 6.900096552972689 2.497840077125218 up GSYVSIHSSGFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GSYVSIHSSGFR 12 0 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8;Q13838-2;Q13838;Q5STU3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;F6R6M7;A0A0G2JHN7;F6SXL5;F6S2B7;F6U6E2;F6QYI9;A0A0G2JJL7 O00148;Q13838-2;F6QYI9 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 685393000.0 182993000.0 236840000.0 265560000.0 False True 277613759.58028954 194574051.56063393 213071949.6009172 1.0 0.7008804313402937 0.7675122080513952 28.048503834170326 -10.113377940561513 5.137509038904241 1.0000074051171677 0.7341963196954125 0.9549908015141282 0.027202308934383638 2.3072905456233517e-06 3.981874005439041e-07 0.0263392557126288 0.008779507456554965 7.702328896208942e-11 10.113377940561513 -0.26581108542175513 GSYVSIHSSGFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GSYVSIHSSGFR 12 0 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8;Q13838-2;Q13838;Q5STU3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;F6R6M7;A0A0G2JHN7;F6SXL5;F6S2B7;F6U6E2;F6QYI9;A0A0G2JJL7 O00148;Q13838-2;F6QYI9 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 436982000.0 158550000.0 68462000.0 209970000.0 False True 217170219.65264386 65437122.466441005 160379410.46789065 1.0 0.3013171998034785 0.738496331239209 27.694251040394416 -10.456973186734919 7.014568900850719 1.0000745120632495 0.5199067655222915 0.6165562613807076 0.17847763303511344 0.00020800802551644795 1.6102830916813497e-05 0.17283679504818436 0.0576034083679594 3.491618720058207e-11 10.456973186734919 -0.48016774654095795 GSYVSIHSSGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GSYVSIHSSGFR 12 0 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8;Q13838-2;Q13838;Q5STU3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;F6R6M7;A0A0G2JHN7;F6SXL5;F6S2B7;F6U6E2;F6QYI9;A0A0G2JJL7 O00148;Q13838-2;F6QYI9 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 298879000.0 109960000.0 57256000.0 131663000.0 False True 91436612.05395444 56947550.56357378 159193124.55906978 1.0 0.622809061757127 1.7410216868614286 26.446268613438583 -6.815724594928128 1.3903652813725105 0.7957785917183187 1.7632473434233962 0.874243935496952 0.16471905958706634 0.19909686320427528 0.757398560991914 0.09312662525721642 0.21491493645289747 1.5285350617085884e-07 6.815724594928128 0.9674687517050775 GSYVSIHSSGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GSYVSIHSSGFR 12 0 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;K7EN69;K7ENP6;K7EL56;K7EIL8;Q13838-2;Q13838;Q5STU3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;F6R6M7;A0A0G2JHN7;F6SXL5;F6S2B7;F6U6E2;F6QYI9;A0A0G2JJL7 O00148;Q13838-2;F6QYI9 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 854393000.0 182993000.0 405610000.0 265790000.0 False True 236888045.83130366 383037446.94015497 217418947.23570186 1.0 1.6169555774584314 0.9178130811654952 27.819630156262775 -6.673763333465218 1.9243303572647668 1.392521999781975 0.9206048845217796 0.2957421507304243 0.2618445370113445 0.45250387951328824 3.234055750649634 0.10941363088987813 0.29086715798067614 2.1195158398043845e-07 6.673763333465218 -0.47191711526019553 GTAAILEYLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTAAILEYLR 10 0 Q9H9A6 Q9H9A6 LRRC40 Leucine-rich repeat-containing protein 40 0 60433000.0 18617000.0 20578000.0 21238000.0 False True 24407067.287284445 17507842.612415764 19040495.48928137 1.0 0.7173267646759417 0.7801222189116125 24.540795617901825 -10.854864054424127 7.334463639759456 1.0216598699332984 0.7487244917937771 0.9552557691312226 0.025636136840614346 0.00870123204168401 0.00017218165609643837 0.02378703749866657 0.008274027587066144 1.3968055294356655e-11 10.854864054424127 -0.2729353781395213 GTAAILEYLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTAAILEYLR 10 0 Q9H9A6 Q9H9A6 LRRC40 Leucine-rich repeat-containing protein 40 0 32179200.0 17645000.0 9214600.0 5319600.0 False True 17084869.133384664 12894037.833504185 3926237.175420767 1.0 0.7547050979927384 0.22980785774640258 24.026215861271076 -7.05500070394346 0.482631675549548 1.0122841330929961 1.0493657776946107e-15 0.9996332866663824 0.0061520850010548635 0.07394805759923806 0.025903131329563057 0.00761668638084621 0.039627765820507796 8.810474449261134e-08 7.05500070394346 -1.012284133092995 down GTAAILEYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTAAILEYLR 10 0 Q9H9A6 Q9H9A6 LRRC40 Leucine-rich repeat-containing protein 40 0 103514000.0 47000000.0 31096000.0 25418000.0 False True 71302436.16025527 25546675.845843043 20394121.158894826 1.0 0.35828615712969186 0.2860227820695799 26.087448033675606 -13.999999999999998 0.30828414744265337 7.14115661417919 0.26972346451565904 0.9996682182335856 0.005845122455698267 17.14859163412459 0.176603163988346 67.4899312520997 0.025219394584792453 1.0000000000000041e-14 13.999999999999998 -6.871433149663531 GTAAILEYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTAAILEYLR 10 0 Q9H9A6 Q9H9A6 LRRC40 Leucine-rich repeat-containing protein 40 0 48621000.0 18617000.0 14261000.0 15743000.0 False True 25500208.00550782 13630901.865179442 12024827.637262484 1.0 0.5345408108920244 0.47155802159202886 24.604005679424716 -13.999999999999998 0.28186086937775173 4.832620433673807 0.4529426489757466 0.9996093027513848 0.004658296527798276 15.499834424486904 0.16820885519765558 34.28135032663757 0.024696225215285503 1.0000000000000041e-14 13.999999999999998 -4.37967778469806 GTAAILEYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTAAILEYLR 10 0 Q9H9A6 Q9H9A6 LRRC40 Leucine-rich repeat-containing protein 40 0 41734300.0 17645000.0 15351000.0 8738300.0 False True 14672599.30603878 15268301.116065063 10565438.128665762 1.0 1.0405996100350883 0.7200795106779315 23.806621136705353 -6.875112398174726 1.1066439188193093 1.0238526005921793 0.6993859790808638 0.9695269653069107 0.024874236796460912 0.13205010138682055 0.29916932099402865 0.017383551883876743 0.04156462511463311 1.3331763529896147e-07 6.875112398174726 -0.32446662151131556 GTAAILEYLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTAAILEYLR 10 0 Q9H9A6 Q9H9A6 LRRC40 Leucine-rich repeat-containing protein 40 0 107396000.0 47000000.0 35037000.0 25359000.0 False True 60842426.50850719 33087160.150001686 20743922.2053131 1.0 0.5438172349252923 0.34094501806913663 25.858574355768056 -13.18332068687576 0.11872409990227117 2.8155943895396858 1.80042675373371e-20 0.9997262309297286 0.004560115536107937 8.97723097559708 0.0976580353271838 4.082506840530198 0.2857164754390055 6.556609416880898e-14 13.18332068687576 -2.8155943895396858 GTADVTHDLQEMK(ub)EESR ddPTM_RPMI8226_Bortezomib_1h_R1 2 GTADVTHDLQEMKEESR 17 1 P11166 P11166 SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 1 70234700.0 26953000.0 24781500.0 18500200.0 True False 35335644.01322332 21084196.797530424 16585976.770449352 1.0 0.5966835297989839 0.46938374079845663 25.074620867432817 -13.999999999999998 0.16140433383171904 2.9922862759660664 0.3461607848478753 0.9995327441261218 0.004889161067337455 12.019303887128165 0.12700516399147246 7.495797738861604 0.11250762651874391 1.0000000000000041e-14 13.999999999999998 -2.646125491118191 GTADVTHDLQEMK(ub)EESR ddPTM_RPMI8226_Bortezomib_2h_R1 2 GTADVTHDLQEMKEESR 17 1 P11166 P11166 SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 1 53887500.0 18098500.0 20826400.0 14962600.0 True False 17523973.02411803 29142490.12824122 11043446.19162171 1.0 1.6630070183361254 0.6301907778802643 24.062826563144984 -6.733369443502079 1.7112524205687738 1.3974947664068933 0.6304512942051522 0.5746995315424437 0.2786452282032661 0.3299474875150425 1.89443538126816 0.12896702501525753 0.3187718039310113 1.8476961611298037e-07 6.733369443502079 -0.7670434722017411 GTADVTHDLQEMK(ub)EESR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTADVTHDLQEMKEESR 17 1 P11166 P11166 SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 1 91058000.0 35137000.0 33041000.0 22880000.0 True False 53305397.858784884 27144575.399488695 18357757.97133974 1.0 0.5092275170968485 0.3443883491869356 25.667778296066466 -13.999999999999998 0.1523870533619027 3.382237758257768 0.16791700254724798 0.9995584683296602 0.005851166281595117 11.967492919984887 0.12305963221813067 8.436450352718571 0.15944148455193766 1.0000000000000041e-14 13.999999999999998 -3.2143207557105202 GTADVTHDLQEMK(ub)EESR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GTADVTHDLQEMKEESR 17 1 P11166 P11166 SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 1 65754200.0 26953000.0 17712500.0 21088700.0 True False 36918252.47743746 16929903.18259528 16107983.395409867 1.0 0.4585781299627323 0.4363148934325708 25.137830928955708 GTADVTHDLQEMK(ub)EESR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GTADVTHDLQEMKEESR 17 1 P11166 P11166 SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 1 49862500.0 18098500.0 19776000.0 11988000.0 True False 15049704.649495216 19669462.762771364 14494635.373750646 1.0 1.3069666960827102 0.9631175967454492 23.84323183857926 -6.671297874249191 1.9329356796124644 1.1957166317140198 0.9645036568321489 0.28478027508975423 0.1303538111964191 0.4581180306995025 3.3011609039775007 0.054269837974716524 0.1447418383313763 2.1315824001949092e-07 6.671297874249191 -0.23121297488187087 GTADVTHDLQEMK(ub)EESR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTADVTHDLQEMKEESR 17 1 P11166 P11166 SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 1 73443000.0 35137000.0 25540000.0 12766000.0 True False 45485539.15381739 24118676.548535664 10442718.99022151 1.0 0.5302493275274609 0.22958327381604973 25.438904618158915 -8.392502364703288 0.2542140063211921 1.2164856160925657 7.33476558787255e-23 0.9993637404525975 0.007996978508043087 0.12358584837869135 0.06286708394334228 0.11609126334165937 0.1070845321345116 4.050397397172398e-09 8.392502364703288 -1.2164856160925657 down GTAEGAVDAMLLHGQDVITVSNGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTAEGAVDAMLLHGQDVITVSNGGR 25 0 Q8N766-3;Q8N766-2;Q8N766 Q8N766-3 EMC1 ER membrane protein complex subunit 1 0 103690000.0 38766000.0 45513000.0 19411000.0 False True 58810856.17422249 37390849.55530796 15574407.341856457 1.0 0.6357814183922189 0.264821979393031 25.809579157760417 -7.470951014414816 0.31746012490284997 1.074915465087764 9.62917604321397e-12 0.9996516994743548 0.005601441554561696 0.121173543192392 0.03218925352578806 0.020288601484281923 0.06309024117615152 3.381029698652932e-08 7.470951014414816 -1.0749154650781347 down GTAEGAVDAMLLHGQDVITVSNGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTAEGAVDAMLLHGQDVITVSNGGR 25 0 Q8N766-3;Q8N766-2;Q8N766 Q8N766-3 EMC1 ER membrane protein complex subunit 1 0 93624000.0 38766000.0 37867000.0 16991000.0 False True 50183351.19210194 35759668.16223175 13898812.34238238 1.0 0.7125803142429387 0.27696062563015583 25.580705479852867 -7.0983797061819605 0.3844553139455846 1.0312819744982782 1.6148290463200695e-13 0.9998542420109786 0.0035885729015437545 0.0761639425261717 0.018414354430653847 0.006558726669852636 0.03637450963442327 7.972973007980177e-08 7.0983797061819605 -1.0312819744981168 down GTAELMQQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTAELMQQK 9 0 E5RJH0;Q93088 E5RJH0 BHMT Betaine--homocysteine S-methyltransferase 1 0 5616000.0 1455600.0 2439500.0 1720900.0 False True 1908305.6960504511 2075536.1090965234 1542837.7760384353 1.0 1.0876329266281513 0.8084856526035576 20.863860867947263 -6.82232056667827 1.3617339101004653 1.0471265998283186 0.8020794322001035 0.889649757038955 0.0387207666564471 0.19048460428451533 0.6934036714823589 0.022340767470611804 0.05146456516478081 1.5054954015454853e-07 6.82232056667827 -0.2450471676282151 GTAELMQQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTAELMQQK 9 0 E5RJH0;Q93088 E5RJH0 BHMT Betaine--homocysteine S-methyltransferase 1 0 5536000.0 1455600.0 2060900.0 2019500.0 False True 1993774.6561109305 1969842.623515064 1542535.6929080617 1.0 0.9879966211213916 0.7736760461771249 20.927070929470155 -6.918439928952043 0.8362280076104486 1.0049999485020484 0.7403267303932375 0.9937362293630886 0.008229108878584185 0.09909827095226535 0.11043894306004107 0.007032262825774856 0.020760443203142073 1.206590970749206e-07 6.918439928952043 -0.26467321810881095 GTAELMQQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTAELMQQK 9 0 E5RJH0;Q93088 E5RJH0 BHMT Betaine--homocysteine S-methyltransferase 1 0 11597800.0 5602800.0 3031700.0 2963300.0 False True 7252935.047699253 2862983.2299215198 2424009.806025645 1.0 0.394734436623654 0.3342108801587269 22.790133498504318 -13.999999999999998 0.3254865545094608 7.41250104259563 0.32291738235960205 0.999705397827393 0.005159620210581027 18.44929990818965 0.1822043376769912 80.7974953073399 0.019728178352259106 1.0000000000000041e-14 13.999999999999998 -7.089583660236028 GTAFVTLLNGEQAEAAINAFHQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTAFVTLLNGEQAEAAINAFHQSR 24 0 A0A087WZ13;E9PAU2;Q8IY67-2;Q8IY67 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 0 14387600.0 8286800.0 1599100.0 4501700.0 False True 8023740.069964986 2237628.9691963335 3322569.721894818 1.0 0.2788760540202916 0.4140923924407881 22.935843439750027 -9.82963940205019 6.4168239424754825 1.0000000201956627 0.3464842232501991 0.9688912548025366 0.05520183900343582 1.5962024075868846e-08 2.854743128837345e-09 0.053448952377766076 0.017816316928289364 1.4803370129002226e-10 9.82963940205019 -0.6535157969454636 GTAFVTLLNGEQAEAAINAFHQSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTAFVTLLNGEQAEAAINAFHQSR 24 0 A0A087WZ13;E9PAU2;Q8IY67-2;Q8IY67 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 0 40572400.0 6953400.0 21656000.0 11963000.0 False True 10548816.161632331 17791317.600899734 9598507.806430835 1.0 1.6865700689343224 0.9099132698266262 23.330577766122765 -6.673306605519286 1.925132496021594 1.4369590751998527 0.9129628952927338 0.2940681748913131 0.2914151735349758 0.453527763519242 3.2434154118649565 0.1217144251703265 0.32385615026813197 2.1217460116299006e-07 6.673306605519286 -0.5239961799071189 GTAFVTLLNGEQAEAAINAFHQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTAFVTLLNGEQAEAAINAFHQSR 24 0 A0A087WZ13;E9PAU2;Q8IY67-2;Q8IY67 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 0 13404400.0 8286800.0 2500900.0 2616700.0 False True 6890841.367485535 2487427.155310217 3163839.871746184 1.0 0.36097582612293944 0.4591369475830304 22.716248715184303 -10.813513580000567 7.328652562166376 1.0253580774437359 0.41005638685298723 0.979657994165307 0.04007411002609776 0.014637130574861006 0.00037245897666381535 0.03420576104903422 0.012933863395430015 1.5363367527024018e-11 10.813513580000567 -0.6153016905907487 GTAQYSSQK(ub)SVEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTAQYSSQKSVEER 14 1 Q99959-2;Q99959 Q99959-2 PKP2 Plakophilin-2 1 6601220.0 1051000.0 1370200.0 4180020.0 True False 1377871.1778984787 1165771.5009977666 3747511.6279831333 1.0 0.8460671212934395 2.719783741829056 20.39400958095514 -6.886979484040709 1.0401120031189113 0.8919122748213778 2.8717019626025597 0.9788924973997029 0.12339340801427354 0.12162697495152212 0.2364511024148801 0.09073436399216492 0.22387170358620587 1.2972405508454974e-07 6.886979484040709 1.979789687781182 up GTAQYSSQK(ub)SVEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTAQYSSQKSVEER 14 1 Q99959-2;Q99959 Q99959-2 PKP2 Plakophilin-2 1 16528120.0 1690800.0 2940900.0 11896420.0 True False 1637126.4794971275 4115216.706590899 8780390.717049995 1.0 2.5136828205570048 5.363294056392667 20.64273435374742 -6.961210882859466 0.4180194475640321 0.8713240733033486 7.112798762480127 0.9998125030223415 0.02476951191852488 0.07927139062341476 0.01955389382405676 0.03681828366214442 0.23734056266277398 1.0934252965602289e-07 6.961210882859466 6.241474689176778 GTAQYSSQK(ub)SVEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTAQYSSQKSVEER 14 1 Q99959-2;Q99959 Q99959-2 PKP2 Plakophilin-2 1 51650500.0 1722400.0 3401100.0 46527000.0 True False 2613006.7243068866 2794147.1320844144 37330918.05649146 1.0 1.0693225953429477 14.286575579476809 21.317279406615754 -6.908050607380317 0.9089052944584409 0.5651117727046511 15.925344299715075 0.9901649512372772 0.619533901663867 0.10572131338577415 0.14586330114131363 0.5023817069934613 1.3687701777423436 1.235803419600748e-07 6.908050607380317 15.360232527010425 up GTAQYSSQK(ub)SVEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTAQYSSQKSVEER 14 1 Q99959-2;Q99959 Q99959-2 PKP2 Plakophilin-2 1 16349130.0 1690800.0 4549530.0 10108800.0 True False 1405975.1151402884 4525020.778879 12222503.342189716 1.0 3.2184216705908715 8.69325723518951 20.423139629181698 -6.955738355927549 0.4918346914533678 0.8821555530489631 11.262403041138345 0.9995780255512666 0.06641616068032034 0.08126015198255514 0.02703549467777651 0.07913953137216248 0.4515502908181259 1.1072906789104195e-07 6.955738355927549 10.380247488089381 GTAQYSSQK(ub)SVEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTAQYSSQKSVEER 14 1 Q99959-2;Q99959 Q99959-2 PKP2 Plakophilin-2 1 28260500.0 1722400.0 2836300.0 23701800.0 True False 2229680.7535798466 2678457.411691922 19388315.60100517 1.0 1.2012739525116076 8.695556783129787 21.088405728708203 -6.9126580214553766 0.8774351199883783 0.78700815230545 9.721230788249073 0.9918865847052462 0.32257680585630905 0.10268677725198576 0.12942619222959384 0.26761842999903784 0.7530917387993938 1.2227621265024435e-07 6.9126580214553766 8.934222635943623 up GTAVVNGEFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTAVVNGEFK 10 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 16994700.0 5116800.0 6445300.0 5432600.0 False True 6708174.35116169 5483686.363582621 4870486.665178925 1.0 0.8174633032060328 0.7260524861485564 22.67748875558593 -13.999999999999705 0.08970939838434228 1.9358595670221315 0.4961050809614474 0.9998437694394791 0.0014234298244962338 12.166302414127458 0.08695349461322842 2.1735154554302825 0.2066561818665052 1.000000000000679e-14 13.999999999999705 -1.4397544860606841 GTAVVNGEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTAVVNGEFK 10 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 13952600.0 4411000.0 1913300.0 7628300.0 False True 4270975.219459323 2677290.6677276893 5630219.3859053785 1.0 0.6268569893661468 1.318251475740973 22.026134096696207 -6.760154767581132 1.6122275465730993 0.783296246986949 1.3207670700482583 0.6914744739749341 0.15694648627495078 0.2826546094217884 1.4481114652927811 0.07681212294413045 0.1845383818276324 1.7371816467784638e-07 6.760154767581132 0.5374708230613093 GTAVVNGEFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTAVVNGEFK 10 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 41943300.0 2855200.0 36317000.0 2771100.0 False True 4331547.14308002 29835947.60398391 2223390.8703837213 1.0 6.888057919824128 0.5133017826980734 22.046450988497543 -6.664001964503675 1.9588602853260153 4.777617494083707 0.539826276201152 0.25262686851120897 2.504646118792522 0.47507028855168254 3.5084000249249594 1.0315694543674219 2.7776061972858646 2.1676942993691854e-07 6.664001964503675 -4.237791217882554 GTAVVNGEFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTAVVNGEFK 10 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 17568000.0 5116800.0 5557200.0 6894000.0 False True 7008619.236320705 5311664.528797088 5265779.186386819 1.0 0.7578760308835863 0.7513290434010195 22.74069881710882 GTAVVNGEFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTAVVNGEFK 10 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 8008600.0 4411000.0 2182100.0 1415500.0 False True 3667941.9404328167 2170344.594187064 1711474.505467468 1.0 0.5917063654314451 0.46660348862160944 21.806539372130484 -13.999999999999998 0.16567958560928095 3.0367945566367816 0.351015132890664 0.9995225932791354 0.00497644217501451 12.052383788005821 0.1287989487270516 7.887456508836924 0.10615092293890199 1.0000000000000041e-14 13.999999999999998 -2.6857794237461174 GTAYTFFTPGNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTAYTFFTPGNLK 13 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 74877000.0 22904000.0 18362000.0 33611000.0 False True 30027365.802651513 15622461.174515389 30133256.139478106 1.0 0.520274115191812 1.003526461079621 24.839774581992312 -10.864656585644045 11.144593210485578 1.0073860385201712 0.7619002881357437 0.24452728157561576 0.19728694407134947 0.03603590635222491 0.000437630394864343 0.19012670605947685 0.0636740874010409 1.3656625948478639e-11 10.864656585644045 -0.24548575038442744 GTAYTFFTPGNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTAYTFFTPGNLK 13 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 57232300.0 17292000.0 8713300.0 31227000.0 False True 16743074.925162237 12192566.129259221 23047711.910080515 1.0 0.7282154672159826 1.3765519185154806 23.997061172499894 -6.792875139524518 1.4852339251521762 0.8486647411534791 1.3839636435844946 0.8103784519707862 0.11575788350098898 0.23109701769155055 1.0070636865430729 0.06134271728567778 0.1432980114541838 1.6111087653817757e-07 6.792875139524518 0.5352989024310155 GTAYTFFTPGNLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTAYTFFTPGNLK 13 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 50707000.0 10269000.0 29803000.0 10635000.0 False True 15578823.764460905 24484421.798098154 8532987.588513907 1.0 1.5716476524982002 0.5477299003779561 23.89308297506688 -6.755197126840021 1.6306701941410573 1.3340190783862849 0.5448656849030581 0.6710287341388133 0.24029796996777378 0.2910519691942155 1.5241767561392674 0.11633783357286327 0.2809066001066489 1.757125871166075e-07 6.755197126840021 -0.7891533934832268 GTAYTFFTPGNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTAYTFFTPGNLK 13 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 69511000.0 22904000.0 23571000.0 23036000.0 False True 31372227.75732671 22529555.281126466 17595371.24131225 1.0 0.7181369284769674 0.5608582016367328 24.902984643515204 -13.653707823224117 0.07154506968014221 2.547916484379254 1.5603511558726687e-17 0.9999264238801043 0.0015582730674640142 10.939285248550645 0.06916685308230985 2.902656023425416 0.49628201688941076 2.219689239912972e-14 13.653707823224117 -2.547916484379254 GTAYTFFTPGNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTAYTFFTPGNLK 13 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 42193000.0 17292000.0 13089000.0 11812000.0 False True 14379064.165487256 13018486.959036909 14281834.5874827 1.0 0.9053779028459992 0.9932381150201745 23.77746644793417 -10.342192636605873 5.456659697188538 1.0000130468969528 0.9493080089980918 0.3074056638378293 0.03586878141990279 5.694630898008702e-06 6.864794504328288e-07 0.03473873607337277 0.011576599424002632 4.5478628940780076e-11 10.342192636605873 -0.05070503789886105 GTAYTFFTPGNLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTAYTFFTPGNLK 13 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 40597000.0 10269000.0 16692000.0 13636000.0 False True 13293422.93225237 15763075.526552763 11154387.91717533 1.0 1.185780036254511 0.8390907273485346 23.664209297159328 -6.761141935368463 1.608181439434476 1.1077574059929063 0.8377522783483504 0.6956212975470955 0.07815272731087466 0.2809966715372072 1.4325623750408536 0.038338817784149104 0.09203027220535097 1.733237451526054e-07 6.761141935368463 -0.27000512764455586 GTAYTFFTPGNLK(ub)QAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTAYTFFTPGNLKQAR 16 1 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 1 12223700.0 4261600.0 5759000.0 2203100.0 True False 5586998.8693931 4899779.648406178 1975144.3456274471 1.0 0.8769967137899971 0.35352510208078874 22.413642097666745 -6.94345304265435 0.6266153023390039 1.0057121142989651 0.1967606215704303 0.9985821116828568 0.010554426097729244 0.08622603497457167 0.04769681253252579 0.010565866069043608 0.04441463934802984 1.1390609342267674e-07 6.94345304265435 -0.8089514927285348 down GTAYTFFTPGNLK(ub)QAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTAYTFFTPGNLKQAR 16 1 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 1 18854100.0 10339000.0 8515100.0 0.0 True False 10010794.104282482 11915223.835659882 0.0 1.0 1.1902376286575218 0.0 23.255053084426386 -6.919510337071468 1.260039629340947 1.1002227584893312 1.4459945893751334e-15 0.9588975882537083 0.1058396563279824 0.122578493975859 0.3894842638211577 0.06907642735514331 0.1349599408094445 1.2036207408854367e-07 6.919510337071468 -1.1002227584893296 down GTAYTFFTPGNLK(ub)QAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTAYTFFTPGNLKQAR 16 1 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 1 26678900.0 10339000.0 14622000.0 1717900.0 True False 8597336.595360456 14543228.38376023 2077104.947327845 1.0 1.6915969524339047 0.2415986537561822 23.035458359860662 -6.776994818579851 1.547408784812746 1.3931333204922096 0.23114511663951293 0.7566469348950573 0.2921217305568553 0.25528487675145184 1.2071296201389539 0.14871497704113384 0.35182156268355896 1.6711105516449174e-07 6.776994818579851 -1.1619882038526967 GTCAFSILFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTCAFSILFK 10 0 F8W9S7;Q14C86-3;Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;B0QZ65;B4DGD8;C9IZ08;A0A0A0MQV8;H0Y4E7;H0Y7I9 F8W9S7 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 0 4629200.0 1287600.0 1420600.0 1921000.0 False True 1688056.0691361378 1208652.0174554281 1722233.347533173 1.0 0.7160022937353944 1.0202465303267594 20.686931393583276 -10.091288948510767 12.589561816449521 0.9999999999919944 0.8681244120418499 0.20032544308141342 0.12420718947190786 0.0 0.0 0.12026309407598207 0.04008769802532735 8.104216817735094e-11 10.091288948510767 -0.13187558795014453 GTDECAIESIAVAATPIPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTDECAIESIAVAATPIPK 19 0 P53634 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 3923380.0 742980.0 2045400.0 1135000.0 False True 974053.9750285561 1740234.2929067553 1017561.0876887817 1.0 1.7865891803949954 1.0446660182860503 19.893642192687455 -10.144965170334125 3.866140510416791 0.999811598717572 1.415627597919567 0.29499843208952015 0.30288886361423645 106724804.70115222 174595848.90862128 265376.5840889592 0.11084597927102222 7.162008459781647e-11 10.144965170334125 0.41581599920199497 GTDECAIESIAVAATPIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTDECAIESIAVAATPIPK 19 0 P53634 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 5926880.0 742980.0 3127600.0 2056300.0 False True 1017679.7842795418 2989412.2904098798 1570644.2908278506 1.0 2.9374783076055797 1.5433580533780333 19.956852254210347 -6.56105706515805 2.3423486768238844 2.3340444169051184 1.545658061395593 0.0 0.8457177804550995 0.7581246282225609 7.796728323430923 0.30694161122385333 0.9509283969546449 2.747533110724493e-07 6.56105706515805 -0.7883863555095254 GTDIMYTGTLDCWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTDIMYTGTLDCWR 14 0 P05141 P05141 SLC25A5 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed 0 12031500.0 3313600.0 4411100.0 4306800.0 False True 4344161.688948048 3752981.0743331257 3861173.6497427677 1.0 0.8639137635878192 0.8888190463918396 22.05064637032611 -10.353643577463599 4.8761159417828015 1.0000871814613008 0.8763664049898456 0.9704640585275685 0.010167539128428936 9.643283771373172e-06 1.2782689742703435e-06 0.009851610203090989 0.0032815591430024457 4.4295175072937314e-11 10.353643577463599 -0.12372077647145518 GTDIMYTGTLDCWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTDIMYTGTLDCWR 14 0 P05141 P05141 SLC25A5 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed 0 11830100.0 3313600.0 3227900.0 5288600.0 False True 4538727.4666729765 3085280.7047621324 4039541.602135962 1.0 0.6797677823611947 0.890016338675886 22.113856431849 -10.395745622133289 4.919784880213528 1.0002290102327585 0.7848920605184988 0.5825818213936114 0.08583361368811168 0.0002158337238744114 2.6508884960432118e-05 0.0831959559040553 0.027702679696550957 4.020262193839908e-11 10.395745622133289 -0.21533694971425965 GTDTVAGLALIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTDTVAGLALIK 12 0 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 21883200.0 7100300.0 5639200.0 9143700.0 False True 9308562.059403002 4797853.341429439 8197597.6365638 1.0 0.5154236831437257 0.880651338439865 23.150126893929926 -9.758110750007555 6.049985249148173 1.0000000092585153 0.6980375107909971 0.47682809299906237 0.14910356590762058 1.862879565784793e-08 3.733608669725404e-09 0.14436891228199553 0.048122968967945635 1.7453770052762642e-10 9.758110750007555 -0.3019624984675182 GTDTVAGLALIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTDTVAGLALIK 12 0 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 22827000.0 7100300.0 8788700.0 6938000.0 False True 9725472.788392711 8400386.173655603 5299387.292595264 1.0 0.8637509308217293 0.5448976525768544 23.213336955452817 -6.9568608531802365 0.4776227581606723 1.0078272440565232 0.387580770940152 0.9996354762506197 0.003641219564972154 0.08084212224306936 0.025423734060381994 0.0044742869979948665 0.026305164833640808 1.1044324204888401e-07 6.9568608531802365 -0.6202464731163713 GTDTVAGLALIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTDTVAGLALIK 12 0 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 9082400.0 4457000.0 2187800.0 2437600.0 False True 3706192.978578345 2176013.8871557037 2947290.889811021 1.0 0.5871291375632574 0.7952340600843644 21.82150657265092 -10.113583477981225 5.32232744758251 1.000005914311126 0.6911815988236081 0.745945570769426 0.08495847885706694 5.9623645528573016e-06 9.931303892312284e-07 0.08226226813831358 0.02742023114427536 7.698684497504023e-11 10.113583477981225 -0.3088243154875179 GTDTVAGLALIK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTDTVAGLALIKK 13 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 14929100.0 5722700.0 4605400.0 4601000.0 True False 7502515.11870563 3918292.271708598 4124932.655908442 1.0 0.5222638288244597 0.5498066435912887 22.83894289039994 -10.697749179565006 6.724205657169956 1.0043061417303114 0.5360352362078808 0.9973639012934961 0.01124430704312081 0.0007293700853042471 3.2784914126589206e-05 0.01093962466022474 0.0036290844931374734 2.005630015265832e-11 10.697749179565006 -0.46827090552243056 GTDTVAGLALIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTDTVAGLALIKK 13 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 17616200.0 5398500.0 5454000.0 6763700.0 True False 5227127.572489497 7631810.642234269 4992084.063349396 1.0 1.4600391010926685 0.9550339061213771 22.317586939249875 -6.667002165516599 1.948373564982491 1.2944015271166618 0.9571164071670318 0.2656846791453059 0.195551898382309 0.4680328445411068 3.422529628959478 0.08089152237481505 0.2169407894245646 2.152771000365196e-07 6.667002165516599 -0.33728511994962995 GTDTVAGLALIK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTDTVAGLALIKK 13 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 44466000.0 14520000.0 13160000.0 16786000.0 True False 22027901.55418954 10811495.180450702 13468239.742434848 1.0 0.49080912922431497 0.6114172840886558 24.392828730218998 -9.961428049311898 7.031565278762948 1.000000022353749 0.5511132066565396 0.9486380504224233 0.049238073039370944 1.722274497281601e-08 2.6268070544394563e-09 0.04767456135141826 0.015891519740068572 1.0928786722226763e-10 9.961428049311898 -0.44888681569720945 GTDTVAGLALIK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTDTVAGLALIKK 13 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 18766000.0 5722700.0 7317200.0 5726100.0 True False 7838536.840152528 6993901.909255385 4373713.112731296 1.0 0.8922458427993167 0.5579757041297759 22.902152951922833 -6.950695437300755 0.5511553692441571 1.0045915088662782 0.42989534762762427 0.9992547375931022 0.00513743769624837 0.08320767285511588 0.0348158362537605 0.005567811497170151 0.027736638575143475 1.1202231999118861e-07 6.950695437300755 -0.574696161238654 GTDTVAGLALIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTDTVAGLALIKK 13 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 17063200.0 5398500.0 7219600.0 4445100.0 True False 4489091.944100335 7180706.5818216065 5374549.8581797555 1.0 1.5995899997679155 1.1972465534467631 22.09799221468415 -10.135001649859769 4.8273465663000374 0.9999734116140669 1.3984182766096704 0.5666201941728801 0.16425602414798293 4.7005956122275125e-05 8.42251718942795e-06 0.15905081025555692 0.05301340383547227 7.328217491859218e-11 10.135001649859769 0.3984448649956035 GTDTVAGLALIK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTDTVAGLALIKK 13 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 45526700.0 14520000.0 18571700.0 12435000.0 True False 18796426.231989916 17538168.569163647 10171957.5938747 1.0 0.933058675766523 0.541164446279841 24.163955052311447 -6.936358116863287 0.6926216154329945 1.0047965003549157 0.4459222137548381 0.9976468032222219 0.00981704808391771 0.08946832077169023 0.06247581705957506 0.009310457204187142 0.03430557060791418 1.1578222285121157e-07 6.936358116863287 -0.5588742866000777 GTDTVAGLALIKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTDTVAGLALIKK 13 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 9243000.0 2971200.0 3323500.0 2948300.0 True False 3895271.9731417284 2827646.754901534 2643238.198090605 1.0 0.7259176700365026 0.6785760317420668 21.893292632041017 -13.999999999916344 0.24703996315522603 2.878044292899515 0.6589974456868473 0.9995372127379811 0.0030480252749545537 13.882571883994629 0.15728384438666088 12.915280408822895 0.022213361913916367 1.0000000001926245e-14 13.999999999916344 -2.2190468472126677 GTDTVAGLALIKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTDTVAGLALIKK 13 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 11647300.0 4068000.0 3347100.0 4232200.0 True False 3938863.5667106244 4683614.484895917 3123659.856721513 1.0 1.189077612253333 0.793035809394664 21.909348015461493 -6.7768598156871995 1.5478953933727426 1.1074959286429484 0.7901902652505539 0.7562003587068709 0.07986004016405496 0.25547995074976587 1.2087940249111906 0.04064315065242259 0.09616393175353787 1.6716301065476516e-07 6.7768598156871995 -0.3173056633923945 GTDTVAGLALIKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTDTVAGLALIKK 13 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 27185400.0 9522500.0 8970400.0 8692500.0 True False 14446328.688000673 7369562.0339449 6974423.564941911 1.0 0.5101339027448658 0.4827817306091732 23.784199564786586 -13.999999999999998 0.4109720595812151 9.86280481893836 0.48157941948037913 0.9998527032685405 0.0028840666555868437 28.459536763733347 0.2126261973909655 225.8163521415946 0.006794243345245096 1.0000000000000041e-14 13.999999999999998 -9.38122539945798 GTDTVAGLALIKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTDTVAGLALIKK 13 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 10510900.0 4068000.0 3550600.0 2892300.0 True False 3382722.2429564116 3531472.2130610766 3497066.5575157655 1.0 1.043973450795257 1.0338024544573368 21.68975329089577 -10.389453968023846 5.753357904642547 0.9999880569719697 1.038887952625826 0.9511988284983466 0.0041522918672704 6.363151183939837e-07 6.75171262325868e-08 0.004021673980430424 0.0013401464375441966 4.078927930741715e-11 10.389453968023846 0.03889989565385621 GTDVNVFNTILTTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTDVNVFNTILTTR 14 0 P04083 P04083 ANXA1 Annexin A1 0 5283200.0 932200.0 3014500.0 1336500.0 False True 1222123.2274376424 2564748.350428969 1198211.8006132646 1.0 2.0986004462138683 0.9804345206051671 20.220958329644542 -6.650198619456899 2.007645505591464 1.712765000868327 0.9851185873956774 0.19492299076264852 0.46887073441406035 0.5080474833347205 3.925262034294983 0.1893816394646007 0.5193970789549424 2.2376975199588945e-07 6.650198619456899 -0.7276464134726497 GTEASTK(ub)NIFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTEASTKNIFGR 12 1 Q96JB5;Q96JB5-4;J3QQY1;J3QS62;J3QL95;J3KRI2;J3KRK4;J3KS63;J3QQS7;J3KTA5 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 3220000.0 1001200.0 1229400.0 989400.0 True False 1312582.8956345925 1045978.3121636674 887026.3789949603 1.0 0.7968855267293193 0.6757869403487168 20.32397710779393 -13.999999862794475 0.053763229981643464 2.3927258653763173 0.03911226234599163 0.9999685060301702 0.0007506526485749255 12.527516056782328 0.056858084099208644 2.4883256885298297 0.6044937099008091 1.0000003159274468e-14 13.999999862794475 -2.3536136030303254 GTEASTK(ub)NIFGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTEASTKNIFGR 12 1 Q96JB5;Q96JB5-4;J3QQY1;J3QS62;J3QL95;J3KRI2;J3KRK4;J3KS63;J3QQS7;J3KTA5 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 4789500.0 1188300.0 1257800.0 2343400.0 True False 1150578.066942534 1760046.0993403506 1729593.2395069222 1.0 1.5297059364406056 1.5032384930672482 20.133927443342404 -10.06348717072541 4.725091578093752 0.9999805941657736 1.5164722147648306 0.9980342110949255 0.010805288547604208 1353716.4296581189 2883141.65574443 165.16909134736412 0.0036989375891090712 8.639981832426597e-11 10.06348717072541 0.5164916205990571 GTEASTK(ub)NIFGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTEASTKNIFGR 12 1 Q96JB5;Q96JB5-4;J3QQY1;J3QS62;J3QL95;J3KRI2;J3KRK4;J3KS63;J3QQS7;J3KTA5 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 23655300.0 2122100.0 7515200.0 14018000.0 True False 3219380.8462910163 6174053.843474403 11247336.155692346 1.0 1.917776783255515 3.493633307985346 21.61835182416244 -6.9629150763644665 0.3921993305946457 0.9055569207694107 4.56267469720876 0.9998634966418346 0.0120312860860915 0.07867584954577257 0.017400915113569965 0.020323111399473626 0.1324360604383076 1.08914304778798e-07 6.9629150763644665 3.6571177764393497 GTEASTK(ub)NIFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTEASTKNIFGR 12 1 Q96JB5;Q96JB5-4;J3QQY1;J3QS62;J3QL95;J3KRI2;J3KRK4;J3KS63;J3QQS7;J3KTA5 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 2846260.0 1001200.0 889930.0 955130.0 True False 1371370.6964126579 850609.9499950318 729547.9655198192 1.0 0.6202625972832334 0.5319845082210299 20.38718716931682 -13.99999999999997 0.20497476336168566 3.1520660041337853 0.47738325650575664 0.9994878139405269 0.004595131803960086 12.633730699274908 0.14353247924730675 10.923998033412877 0.054195310024974026 1.0000000000000696e-14 13.99999999999997 -2.6746827476280286 GTEASTK(ub)NIFGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTEASTKNIFGR 12 1 Q96JB5;Q96JB5-4;J3QQY1;J3QS62;J3QL95;J3KRI2;J3KRK4;J3KS63;J3QQS7;J3KTA5 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 4075100.0 1188300.0 1490100.0 1396700.0 True False 988124.100615806 1482072.5355383074 1688743.5123888475 1.0 1.4998850191131552 1.7090398982642065 19.91433271877668 -11.151131862533648 0.16372064714244625 4.6924613166317614e-18 1.946337816836571 0.9995622058938612 0.006224013355152507 3.4706078214037936 0.09664575673242852 1.459050720289195 0.17438203844513986 7.061031313580989e-12 11.151131862533648 1.946337816836571 GTEASTK(ub)NIFGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTEASTKNIFGR 12 1 Q96JB5;Q96JB5-4;J3QQY1;J3QS62;J3QL95;J3KRI2;J3KRK4;J3KS63;J3QQS7;J3KTA5 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 20821400.0 2122100.0 4426300.0 14273000.0 True False 2747100.2828447483 4179972.513969591 11675460.453347294 1.0 1.5215944390792453 4.250103473200046 21.389478146254888 -6.938802354083312 0.6706114627083585 0.9686471650118985 4.960679753575662 0.9980028067183623 0.06369081801309512 0.08831725420843729 0.057129503370773244 0.061449534909712 0.23610342162205514 1.1513242334122135e-07 6.938802354083312 3.9920325885637635 up GTEITHAVVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTEITHAVVIK 11 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 9064200.0 2702300.0 3324600.0 3037300.0 False True 3542741.469110427 2828582.6391892983 2723029.3318388835 1.0 0.7984163292331765 0.7686220842196055 21.756434758223502 -13.999999999999998 0.2692327331849677 2.549506274485652 0.7586585251229633 0.9995816784343636 0.0021019859052193346 14.845588088511175 0.1642492452323478 12.584882716017816 0.012421803818305025 1.0000000000000041e-14 13.999999999999998 -1.7908477493626886 GTEITHAVVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTEITHAVVIK 11 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 8215900.0 2702300.0 2055600.0 3458000.0 False True 3701413.3369116313 1964776.7950398219 2641291.619745521 1.0 0.5308179919941564 0.7135900207106699 21.819644819746394 -10.123025111455759 5.21174247470585 1.0000101552372092 0.6222040063520325 0.8506758245494003 0.07461636826945775 8.80481590146898e-06 1.4815644029955923e-06 0.07224892896839402 0.024082329304982785 7.533120050223342e-11 10.123025111455759 -0.3778061488851766 GTEITHAVVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTEITHAVVIK 11 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 3743820.0 1055300.0 1820700.0 867820.0 False True 877528.7077167878 1810891.527719345 1049277.1496536783 1.0 2.063626536425278 1.1957183171633858 19.743086797350514 -10.261714113032754 4.165927125431343 0.999479270235651 1.6296724268231102 0.41239085807125975 0.35432204692278585 250587771.2797352 1143.6653652157552 1271601.5109022295 0.12129386105620792 5.4737617059837584e-11 10.261714113032754 0.6301931565874592 GTEITHAVVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTEITHAVVIK 11 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 5832000.0 2551600.0 3280400.0 0.0 False True 3303096.499555472 3097842.8562966487 0.0 1.0 0.937860234090513 0.0 21.655387687720385 -7.077140531852355 1.0169249447665922 1.0053405534299815 3.882686554822446e-21 0.9889559599683764 0.04807496629824598 0.08436381631505152 0.16677732772195178 0.03913422203494791 0.06950959760855756 8.372583127607445e-08 7.077140531852355 -1.0053405534299815 down GTEITHAVVIKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTEITHAVVIKK 12 1 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 3338690.0 780890.0 1157200.0 1400600.0 True False 1023754.3521495182 984550.2707302715 1255679.3475038842 1.0 0.961705577771726 1.2265435989282063 19.965438154339353 -6.870194891737321 1.1329903784473476 0.9783138106719 1.242116310620359 0.9648810812505122 0.021901510849520012 0.13667199594215826 0.32777131742365073 0.014999707000912143 0.03552645701852754 1.348357664818139e-07 6.870194891737321 0.26380249994845895 GTEVQVDDIK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTEVQVDDIKR 11 1 Q9Y230;Q9Y230-2 Q9Y230 RUVBL2 RuvB-like 2 1 7244400.0 3117800.0 2006600.0 2120000.0 True False 4270534.91537693 1917941.7770611534 1619299.6627705304 1.0 0.44911043114416743 0.37917958636514426 22.025985358473882 -13.999999999999998 0.2910257645882825 5.774546408549037 0.36031938032331984 0.9996297581924006 0.005342376550777437 16.02702742853991 0.1710985527888372 45.84090812992599 0.02628939646576884 1.0000000000000041e-14 13.999999999999998 -5.414227028225717 GTEVQVDDIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTEVQVDDIKR 11 1 Q9Y230;Q9Y230-2 Q9Y230 RUVBL2 RuvB-like 2 1 11082500.0 2840000.0 5887500.0 2355000.0 True False 2361585.8333323994 5855782.868922747 2847419.611710273 1.0 2.4795977288954756 1.2057235318406025 21.171324541430312 -6.609820551793944 2.154599795818059 1.9886705423084339 1.2102958452281642 0.04970747129495312 0.6379394099041894 0.6131983521012608 5.3941725650997165 0.24453845457861015 0.7081652673790593 2.4557233981316826e-07 6.609820551793944 -0.7783746970802696 GTEYYDGK(ub)TR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTEYYDGKTR 10 1 Q8N3C0 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 1 6500040.0 866940.0 1421000.0 4212100.0 True False 1315211.361803654 1167411.4476763264 3379576.5887709837 1.0 0.8876226906034039 2.5696072030097894 20.326863236615612 -6.890916112817722 1.0169128544818313 0.9116001964939567 2.716915987284235 0.9814794129933303 0.10448738199672543 0.11840435882021175 0.2175142797527856 0.0781920493570138 0.1955946305034188 1.2855349465199148e-07 6.890916112817722 1.8053157907902784 up GTEYYDGK(ub)TR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTEYYDGKTR 10 1 Q8N3C0 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 1 3074340.0 866940.0 0.0 2207400.0 True False 1122270.9199422395 0.0 1805675.8498366717 1.0 0.0 1.6089482652990825 20.09798955870806 -6.738629359978518 1.6918166701112012 0.4040533341631194 1.6095916432029782 0.5987132157429982 0.42017298924338553 0.32031011903862894 1.7996388534640124 0.1965211530131943 0.482953707589502 1.8254529343722724e-07 6.738629359978518 1.2055383090398588 GTFQIVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTFQIVYK 8 0 Q9NXG2 Q9NXG2 THUMPD1 THUMP domain-containing protein 1 0 30096000.0 11026000.0 7270000.0 11800000.0 False True 14455192.775935905 6185344.338238043 10579049.19359263 1.0 0.4278977412556555 0.7318511318094606 23.785084513084072 -10.181431176581512 5.267050350945394 1.0000205085873368 0.5798744365324144 0.7180967913419143 0.12408845207484123 2.9885280599730937e-05 4.644534629785162e-06 0.12015398572533975 0.04004937569512969 6.585197784748023e-11 10.181431176581512 -0.4201460720549224 GTFQIVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTFQIVYK 8 0 Q9NXG2 Q9NXG2 THUMPD1 THUMP domain-containing protein 1 0 23659800.0 8089400.0 3851400.0 11719000.0 False True 7832606.424913694 5389284.1047856705 8649442.337535905 1.0 0.6880575650582436 1.104286602480631 22.901061036557223 -6.706131240698047 1.8089059643510033 0.807470420105721 1.1032045897745417 0.4467210514790546 0.13153348116169006 0.382922129220666 2.439946538463448 0.05791797067442097 0.14783821514159415 1.9672916983366094e-07 6.706131240698047 0.2957341696688207 GTFQIVYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTFQIVYK 8 0 Q9NXG2 Q9NXG2 THUMPD1 THUMP domain-containing protein 1 0 23657800.0 5262500.0 10291000.0 8104300.0 False True 7983597.240283918 8454490.646050017 6502481.552759127 1.0 1.0589826104190287 0.8144801593883864 22.928607510177006 -6.843005924633713 1.2684719601663947 1.0313745239314387 0.8059534510280015 0.9294815472040614 0.02766486284933247 0.1653191704274572 0.5154241610456959 0.017093032576931805 0.03941411185880635 1.4354698505787512e-07 6.843005924633713 -0.22542107290343716 GTFQIVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTFQIVYK 8 0 Q9NXG2 Q9NXG2 THUMPD1 THUMP domain-containing protein 1 0 25196900.0 11026000.0 5744700.0 8426200.0 False True 15102610.16644624 5490880.158817495 6436105.103036348 1.0 0.363571601087651 0.42615846082921255 23.848294574606964 -10.07105802787938 5.011387946204431 1.0000133833133942 0.39486503096501646 0.9920411049854282 0.02555097850531957 70938894.00238627 2.82448773342991 10955.268846041814 0.008746779556990542 8.490670201056568e-11 10.07105802787938 -0.6051483523483777 GTFQIVYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTFQIVYK 8 0 Q9NXG2 Q9NXG2 THUMPD1 THUMP domain-containing protein 1 0 15402100.0 8089400.0 3521300.0 3791400.0 False True 6726694.521182788 3502330.0579766757 4584164.210547057 1.0 0.5206613808531986 0.6814883887043233 22.6814663119915 -10.569003580475462 7.637248966214858 1.0002038282706058 0.601074884778761 0.8913466526412624 0.06565735101563992 0.0002279832599509015 1.286583689145135e-05 0.06360412047853362 0.021190818919972338 2.697717191430065e-11 10.569003580475462 -0.3991289434918448 GTFQIVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTFQIVYK 8 0 Q9NXG2 Q9NXG2 THUMPD1 THUMP domain-containing protein 1 0 27957900.0 5262500.0 15735000.0 6960400.0 False True 6812409.9893833995 14859333.417823369 5693678.619735057 1.0 2.181215376200267 0.8357803814814733 22.699733832269455 -6.674760271600693 1.9200192294193366 1.750819563818878 0.841025175619816 0.3005736568373434 0.5012039852731749 0.4502387279631906 3.2041525553154035 0.20979467806715563 0.5571602145941543 2.114655997348544e-07 6.674760271600693 -0.9097943881990619 GTGAASFDEFGNSK(ub)YQNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTGAASFDEFGNSKYQNR 18 1 B1APE1;B1APE2;Q00403 B1APE1 GTF2B Transcription initiation factor IIB 1 15452130.0 7417300.0 7201400.0 833430.0 True False 6167813.592104361 7162604.628834011 1007696.3596550724 1.0 1.1612874678967466 0.16337983381097324 22.55632773311628 -6.865469764696518 1.157701293652522 1.0891520633487581 0.1097347020016333 0.9599538550854455 0.08752784593241733 0.14127757313757433 0.35673685439673974 0.05881978933421988 0.13827232140307735 1.3631079016029777e-07 6.865469764696518 -0.9794173613471249 down GTGASGSFK(ub)LNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTGASGSFKLNK 12 1 P10412;Q02539;P16401;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1B;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1.5;Histone H1.3;Histone H1.2 1 4772140.0 736740.0 2380000.0 1655400.0 True False 965873.2746003101 2024913.2771673365 1484115.0877180705 1.0 2.096458542147022 1.5365525962318556 19.881474390103634 -10.039172154540672 5.264624830176674 0.9999928622555904 1.8165055691911918 0.739276569369582 0.22858064524654823 34111962.63999234 65048477.96036164 1924.1202363744312 0.07824924269694535 9.137509583527758e-11 10.039172154540672 0.8165127069356014 GTGASGSFK(ub)LNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTGASGSFKLNK 12 1 P10412;Q02539;P16401;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1B;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1.5;Histone H1.3;Histone H1.2 1 15532900.0 2413800.0 6640200.0 6478900.0 True False 2337175.240247317 9291666.488185555 4781881.727166257 1.0 3.9755968350932562 2.046009064626341 21.156334480063414 -9.97325329506473 6.323225683316501 0.9999993530340519 3.010802949859875 0.5914922107735687 0.7877509085933687 7.1864112679576815e-06 1.168341014760987e-06 0.7627367874604587 0.2542455124951163 1.0635225553858843e-10 9.97325329506473 2.0108035968258235 GTGASGSFK(ub)LNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTGASGSFKLNK 12 1 P10412;Q02539;P16401;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1B;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1.5;Histone H1.3;Histone H1.2 1 2756390.0 736740.0 581040.0 1438610.0 True False 1009132.6876498825 555367.7315576655 1098839.9471029786 1.0 0.5503416333198293 1.0888954054813256 19.944684451626525 -6.685163222262313 1.8832380354192173 0.7168166360309921 1.0869461981402269 0.34786651790042855 0.19036657995721926 0.42725551011710633 2.9338516213407067 0.08097513314514974 0.21218794149136522 2.0646040633344336e-07 6.685163222262313 0.37012956210923476 GTGASGSFK(ub)LNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTGASGSFKLNK 12 1 P10412;Q02539;P16401;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1B;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1.5;Histone H1.3;Histone H1.2 1 10228440.0 2413800.0 5895200.0 1919440.0 True False 2007181.649471035 5863441.387494419 2320786.0295121716 1.0 2.9212310649809137 1.1562411554149983 20.93673975549769 -6.626019669225776 2.094749948916392 2.2693894088890274 1.1632109951863627 0.1033575527020395 0.8249391898017928 0.5694841532788879 4.756550861238885 0.3226687862391647 0.9141884549512521 2.3658125472528015e-07 6.626019669225776 -1.1061784137026647 GTGDVK(ub)LLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTGDVKLLK 9 1 P43487-2;P43487;F6WQW2;C9JXG8;C9JJ34;C9JGV6;C9JDM3;C9JIC6 P43487-2 RANBP1 Ran-specific GTPase-activating protein 1 3687220.0 1126100.0 1685000.0 876120.0 True False 1476328.0051679132 1433604.5680785563 785467.506736472 1.0 0.9710610129051249 0.5320413241413349 20.493581859053815 -6.920287803736037 0.8225907993823136 1.0095866073726272 0.46077499300345637 0.9942604400937718 0.016220421638796015 0.09800282889713526 0.10473949633165194 0.013996868324815982 0.042043234578751636 1.2014679668184016e-07 6.920287803736037 -0.5488116143691708 GTGDVK(ub)LLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTGDVKLLK 9 1 P43487-2;P43487;F6WQW2;C9JXG8;C9JJ34;C9JGV6;C9JDM3;C9JIC6 P43487-2 RANBP1 Ran-specific GTPase-activating protein 1 8617400.0 2420100.0 3124700.0 3072600.0 True False 2343275.250195762 4372409.005095237 2267793.883975835 1.0 1.8659391399836434 0.967788092238152 21.160094998031813 -6.654562361854823 1.9932456508251095 1.5598962186723488 0.9716319317206259 0.2124319741931191 0.36918637497548357 0.49739439633332855 3.793233017479218 0.1499837709774083 0.4087920585500576 2.2153259671138268e-07 6.654562361854823 -0.588264286951723 GTGDVK(ub)LLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTGDVKLLK 9 1 P43487-2;P43487;F6WQW2;C9JXG8;C9JJ34;C9JGV6;C9JDM3;C9JIC6 P43487-2 RANBP1 Ran-specific GTPase-activating protein 1 3201440.0 1126100.0 971040.0 1104300.0 True False 1542449.601708244 928136.2420001288 843487.0837724052 1.0 0.6017287313454063 0.5468490398897011 20.556791920576707 -13.999999999999998 0.279257404354579 4.232630625071262 0.5302066014641094 0.9996035349440795 0.004020689348782568 15.358248256557713 0.16739088626889104 28.3421314080535 0.021785803593954756 1.0000000000000041e-14 13.999999999999998 -3.7024240236071524 GTGDVK(ub)LLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTGDVKLLK 9 1 P43487-2;P43487;F6WQW2;C9JXG8;C9JJ34;C9JGV6;C9JDM3;C9JIC6 P43487-2 RANBP1 Ran-specific GTPase-activating protein 1 9112740.0 2420100.0 5935600.0 757040.0 True False 2012420.3786083562 5903623.744675648 915333.5638425255 1.0 2.9335937001185437 0.4548421262139592 20.94050027346609 -6.698528155537175 1.8358195359585776 2.202381648090905 0.46234067044194466 0.41074220588689336 0.8164119965647153 0.3985863819751657 2.610516276143227 0.3548983280782521 0.9144681556112474 2.002035824357755e-07 6.698528155537175 -1.7400409776489603 GTGDVK(ub)LLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTGDVKLLK 9 1 P43487-2;P43487;F6WQW2;C9JXG8;C9JJ34;C9JGV6;C9JDM3;C9JIC6 P43487-2 RANBP1 Ran-specific GTPase-activating protein 1 4886700.0 1979600.0 1393100.0 1514000.0 True False 2562631.2237498057 1315572.7603666817 1238467.534951853 1.0 0.5133679587504798 0.48327965548614843 21.289194451407973 -13.999999999999998 0.39589636427284747 8.98984666512516 0.4813409689020049 0.9998318839555655 0.0030704786358843575 26.17485849249683 0.2069045325218363 179.37011301741535 0.007787551085423111 1.0000000000000041e-14 13.999999999999998 -8.508505696223155 GTGGIFEVCWNAAGDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTGGIFEVCWNAAGDK 16 0 Q9BZK7;A0A0D9SFI2 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 16480700.0 5393700.0 6823900.0 4263100.0 False True 6982250.975722033 6444143.966309806 3487259.5430998984 1.0 0.9229321588004675 0.4994463182755017 22.735260784553713 -6.93772323715762 0.6804131450475348 1.004992564120642 0.3925085187601506 0.9978502512614706 0.010203118489427355 0.0888207915155893 0.059455410279717846 0.009768345100718744 0.03682910538500307 1.1541885532390896e-07 6.93772323715762 -0.6124840453604915 down GTGIVSAPVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTGIVSAPVPK 11 0 P15880;H0YEN5;E9PQD7;E9PMM9;I3L404;E9PM36 P15880 RPS2 40S ribosomal protein S2 0 22931040.0 823040.0 10417000.0 11691000.0 False True 1079013.4103306986 8862824.205147961 10481327.467990795 1.0 8.213822108505271 9.713806489929029 20.041281364546183 -9.283236017530758 0.5321130126892366 4.504259410834496e-18 9.666526291981508 0.9978458965728992 0.176542880998051 0.6580352867111383 0.22447322806589273 1.8187152372517141 0.2861183230996817 5.20911544556294e-10 9.283236017530758 9.666526291981508 GTGIVSAPVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTGIVSAPVPK 11 0 P15880;H0YEN5;E9PQD7;E9PMM9;I3L404;E9PM36 P15880 RPS2 40S ribosomal protein S2 0 15636800.0 6704900.0 1656400.0 7275500.0 False True 6492056.619576701 2317809.1580118905 5369828.289678514 1.0 0.3570223264878145 0.827138240520866 22.63024415153081 -9.851986412076135 6.278267529489174 1.000000025295208 0.5920802835043525 0.5009660626063048 0.19192401822424254 6.787790996599734e-08 1.234961289417704e-08 0.18582964265603558 0.06194321052658391 1.40609151632043e-10 9.851986412076135 -0.40791974179085544 GTGIVSAPVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTGIVSAPVPK 11 0 P15880;H0YEN5;E9PQD7;E9PMM9;I3L404;E9PM36 P15880 RPS2 40S ribosomal protein S2 0 19424140.0 823040.0 10785000.0 7816100.0 False True 1127340.1298196907 10308483.038774308 5970098.157632425 1.0 9.144075302653397 5.295738171395794 20.104491426069075 -9.954739473897709 11.785624393412993 1.0001375734070457 7.219906737024595 0.7769377953042258 1.5710770569723225 0.0 0.0 1.5211888184083713 0.5070629394694569 1.1098403905681592e-10 9.954739473897709 6.219769163617549 GTGLYELWK(ub)SGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTGLYELWKSGR 12 1 Q9H9T3-2;Q9H9T3;B4DKA4;Q9H9T3-4;Q9H9T3-5 Q9H9T3-2 ELP3 Elongator complex protein 3 1 6005000.0 1229500.0 1463000.0 3312500.0 True False 1684079.3759881754 1398359.8225059614 2530155.7230789578 1.0 0.8303408036722967 1.5023969529906072 20.683528708111933 -6.839825900083865 1.283403754389653 0.9097481810517767 1.5243974053114215 0.9241203317502147 0.07860459565588665 0.16900519366853486 0.5408490389487041 0.04802971609708102 0.11063365793486105 1.4460193346155911e-07 6.839825900083865 0.6146492242596449 GTGLYELWK(ub)SGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTGLYELWKSGR 12 1 Q9H9T3-2;Q9H9T3;B4DKA4;Q9H9T3-4;Q9H9T3-5 Q9H9T3-2 ELP3 Elongator complex protein 3 1 7266300.0 2117800.0 2734000.0 2414500.0 True False 1761044.534447662 2719271.399343488 2919360.786613358 1.0 1.5441241525424376 1.6577438727459513 20.747999962771768 -11.573884233559966 0.27059244203185495 1.1965820659739717e-16 1.7002575174769212 0.9993364700653474 0.007394280825375518 4.103263025763205 0.1491973565910035 2.4269319475103814 0.046915766324753715 2.667569642667436e-12 11.573884233559966 1.700257517476921 GTGQSDDSDIWDDTALIK(ub)AYDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTGQSDDSDIWDDTALIKAYDK 22 1 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;Q16637-4;Q16637-2;B4DP61 A0A1W2PRV5 SMN1;SMN2 Survival motor neuron protein 1 16300700.0 6865200.0 4661000.0 4774500.0 True False 6647267.983820486 6522161.606793899 3523915.2180702384 1.0 0.9811792788659797 0.5301298558516795 22.664330086471697 -6.915670084594931 0.8562160699847374 1.0115879996003676 0.4641733944221219 0.992891343322651 0.018312646472682288 0.100787112765881 0.11930846083566966 0.015426546797421913 0.04445931411993307 1.2143109615689994e-07 6.915670084594931 -0.5474146051782457 GTGQSDDSDIWDDTALIK(ub)AYDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTGQSDDSDIWDDTALIKAYDK 22 1 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;Q16637-4;Q16637-2;B4DP61 A0A1W2PRV5 SMN1;SMN2 Survival motor neuron protein 1 6217900.0 1789100.0 1770600.0 2658200.0 True False 2450578.618609554 1692369.0374087866 2030387.907347466 1.0 0.6905997728687555 0.828534082493341 21.224691000854015 -10.164374531636227 4.892365468353288 1.0000196249650506 0.7595669276803161 0.8020268202154028 0.056311446103079775 14839865.2122023 30831293.180252668 2116.5606686404876 0.019276907801191803 6.848973224330811e-11 10.164374531636227 -0.2404526972847345 GTGQSDDSDIWDDTALIK(ub)AYDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTGQSDDSDIWDDTALIKAYDK 22 1 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;Q16637-4;Q16637-2;B4DP61 A0A1W2PRV5 SMN1;SMN2 Survival motor neuron protein 1 16229300.0 6865200.0 6064400.0 3299700.0 True False 5708717.979927316 6031729.87351084 3989652.013910989 1.0 1.0565822124545792 0.6988700489215243 22.444735361905973 -6.866440700561361 1.152825700279637 1.0314030764176425 0.6792962064055371 0.9609962389947999 0.03100635545618613 0.14030960782669483 0.350762116429923 0.020916186152556318 0.04923384856564626 1.36006385645053e-07 6.866440700561361 -0.3521068700121054 GTHFNFAIVFTDVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTHFNFAIVFTDVK 14 0 O00422;O00422-2;U3KPY7;H7BZW6 O00422 SAP18 Histone deacetylase complex subunit SAP18 0 34380000.0 16694000.0 17686000.0 0.0 False True 25326018.49487876 14529795.118651295 0.0 1.0 0.57371019931891 0.0 24.594116952900915 -7.718731736032991 0.6419628439180401 1.001003675220051 4.3764744427377385e-19 0.9875764880125102 0.04566820724130173 0.11963514516597457 0.15197989213628293 0.04289069755931282 0.07789939385969229 1.9110333405229324e-08 7.718731736032991 -1.001003675220051 down GTHFNFAIVFTDVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTHFNFAIVFTDVK 14 0 O00422;O00422-2;U3KPY7;H7BZW6 O00422 SAP18 Histone deacetylase complex subunit SAP18 0 25516300.0 16694000.0 0.0 8822300.0 False True 21610712.087936584 0.0 7216731.924442365 1.0 0.0 0.33394234743754003 24.365243274993365 -10.515783982928003 6.196528412600162 1.0008321502010595 0.16697117371879303 0.8924372527323562 0.1363313924548652 0.001568627806879907 0.00012257744152432607 0.13211543441287188 0.04400076771191335 3.049411382648545e-11 10.515783982928003 -0.8338609764822665 GTHFVQLCCQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTHFVQLCCQR 11 0 Q9HCC0-2;Q9HCC0;D6RD67 Q9HCC0-2 MCCC2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial 0 8167800.0 2547800.0 2466200.0 3153800.0 False True 3340190.472930301 2098252.5731723052 2827475.029385797 1.0 0.6281835093468603 0.8465011358784261 21.67149894343572 -10.24116334325582 5.535727266329778 1.0000165454021746 0.7373423226126313 0.6586948008758948 0.08912779780968191 1.8200972866234047e-05 2.494955337412573e-06 0.0863030511572229 0.02876587305008057 5.739005708645606e-11 10.24116334325582 -0.2626742227895432 GTHFVQLCCQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTHFVQLCCQR 11 0 Q9HCC0-2;Q9HCC0;D6RD67 Q9HCC0-2 MCCC2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial 0 6036700.0 2547800.0 1444400.0 2044500.0 False True 3489790.511706125 1380581.6320079367 1561631.2077992214 1.0 0.3956058758761951 0.44748565925688044 21.73470900495861 -10.381037243703245 9.11642044734095 1.0000013168740491 0.42154576913603475 0.9940033672367793 0.021179832874800356 5.668924765255188e-07 3.8481128886290344e-08 0.02050733173829867 0.006835761666629864 4.158749448619922e-11 10.381037243703245 -0.5784555477380144 GTIEILSDVQLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTIEILSDVQLIK 13 0 P05388;F8VU65;F8VW21;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 6153270.0 3944070.0 2209200.0 0.0 False True 5170713.964428209 1879595.971394155 0.0 1.0 0.36350801539686517 0.0 22.30193206878585 -8.4359481678458 0.5191261178432549 1.0449566699793273 3.013879344012178e-19 0.9930238641820861 0.03451913336210859 0.1957974301912481 0.18186303068949355 0.07231833374397735 0.06818115401047319 3.6648131082941806e-09 8.4359481678458 -1.0449566699793273 GTIEILSDVQLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTIEILSDVQLIK 13 0 P05388;F8VU65;F8VW21;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 37658600.0 13976000.0 9565600.0 14117000.0 False True 13532339.530075623 13385193.963945005 10419334.19907794 1.0 0.9891263764256294 0.7699580827041008 23.68990794452075 -6.9172144101169994 0.845126152064626 1.0053381339649905 0.7367842415973175 0.993371562187366 0.008627803212551731 0.09983869412751896 0.11431102234467613 0.007326099732695389 0.021393419666215205 1.2100006117406606e-07 6.9172144101169994 -0.268553892367673 GTIEILSDVQLIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTIEILSDVQLIK 13 0 P05388;F8VU65;F8VW21;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 279182800.0 62144800.0 145240000.0 71798000.0 False True 94278204.99344333 119320787.23470047 57607093.82981864 1.0 1.2656243003671819 0.6110329936152793 26.490420954919788 -6.796561903268827 1.4700788521974884 1.1472017924593034 0.6027627980817649 0.8218683341378062 0.11345404998891144 0.22570498625103594 0.9633384555516207 0.06072644293023501 0.141522744945235 1.5974898105556308e-07 6.796561903268827 -0.5444389943775385 GTIEILSDVQLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTIEILSDVQLIK 13 0 P05388;F8VU65;F8VW21;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 10146370.0 3944070.0 2576700.0 3625600.0 False True 5402299.263484086 2462852.87399256 2769307.9515758674 1.0 0.45588975246887764 0.5126165390900369 22.36514213030874 -10.303946596703904 5.642343193987795 1.0000609624598495 0.48425314578343326 0.9910083007354102 0.023158613661617682 1.7761893142946786e-05 2.1911343196492526e-06 0.02242586731466789 0.007474410419388341 4.966533889942659e-11 10.303946596703904 -0.5158078166764163 GTIEILSDVQLIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTIEILSDVQLIK 13 0 P05388;F8VU65;F8VW21;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 29965700.0 13976000.0 6852300.0 9137400.0 False True 11621663.241779441 6815385.299824936 11047988.093435865 1.0 0.5864380302574835 0.9506374314580691 23.470313219955028 -10.232098123563897 7.872820840418005 1.0000002084137223 0.7685377308577763 0.35003457737979105 0.14868378292810164 5.439501606725536e-07 5.286174438541152e-08 0.14396258249339788 0.04798748459430469 5.860057486735494e-11 10.232098123563897 -0.23146247755594596 GTIEILSDVQLIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTIEILSDVQLIK 13 0 P05388;F8VU65;F8VW21;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 173148800.0 62144800.0 66164000.0 44840000.0 False True 80447668.65714642 62481915.23716966 36679580.09725298 1.0 0.77667776183119 0.4559433568370364 26.261547277012237 -6.965969536088519 0.3410032400590464 1.0343864287596196 0.18755957670374532 0.9999317578002734 0.0018445949196389797 0.07763349304013245 0.013708354793620122 0.004513858937230412 0.027740651231000165 1.0815098119524722e-07 6.965969536088519 -0.8468268520558743 down GTIEILSDVQLIK(ub)TGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTIEILSDVQLIKTGDK 17 1 P05388;F8VU65;F8VW21;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 24946280.0 8828400.0 10116980.0 6000900.0 True False 8548147.274421843 14156742.873353716 4429084.2668588795 1.0 1.6561182697113992 0.5181338276788688 23.02718033345757 -6.750359766895396 1.6484346171172346 1.385639510472866 0.5158012762491598 0.6505330529504736 0.2757111247079844 0.2994266887476312 1.6009393772874787 0.13211688125112042 0.3206329017906357 1.776806904232031e-07 6.750359766895396 -0.8698382342237062 GTIEILSDVQLIK(ub)TGDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTIEILSDVQLIKTGDK 17 1 P05388;F8VU65;F8VW21;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 75652000.0 26639500.0 31609500.0 17403000.0 True False 40414069.10832171 25968537.758849278 13963289.421994131 1.0 0.6425618189855092 0.3455056550868057 25.26835428143077 -7.581486010815023 0.23120242415288933 1.1616055772582539 2.714492458832657e-12 0.9998803799145448 0.0029264876060117306 0.1304164865083016 0.02532043136672905 0.0341500220009752 0.07187945696919844 2.6212834721943076e-08 7.581486010815023 -1.1616055772555394 down GTIEILSDVQLIK(ub)TGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTIEILSDVQLIKTGDK 17 1 P05388;F8VU65;F8VW21;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 5452330.0 2989400.0 926030.0 1536900.0 True False 4094661.9654973983 885114.932628295 1173915.8734490718 1.0 0.21616312655024647 0.28669420903136034 21.96531292452862 -10.103410369142024 5.088133848572625 1.000020524148203 0.2514286680482458 0.9933858511036094 0.028794193853544123 6.704123275139397e-06 1.181365911019459e-06 0.027880621071034766 0.009293286104317122 7.881150679659375e-11 10.103410369142024 -0.7485918560999572 GTIEILSDVQLIK(ub)TGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTIEILSDVQLIKTGDK 17 1 P05388;F8VU65;F8VW21;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 25060600.0 8828400.0 12516700.0 3715500.0 True False 7341205.764433719 12449270.052729579 4492393.8714690115 1.0 1.69580726275827 0.6119422361423952 22.807585608891845 -6.733354797400452 1.7112280060973795 1.4171643528665347 0.6122079830028819 0.5746660906694716 0.29243075085143 0.3299747963187848 1.8945170926395345 0.1353475027292407 0.3345581054570894 1.8477584736923523e-07 6.733354797400452 -0.8049563698636528 GTIEILSDVQLIK(ub)TGDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTIEILSDVQLIKTGDK 17 1 P05388;F8VU65;F8VW21;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 77001400.0 26639500.0 33969900.0 16392000.0 True False 34485357.89305059 32079445.203057986 13408824.196123352 1.0 0.9302337908902074 0.38882659236734984 25.03948060352322 -6.930666750732346 0.7413006433212166 1.00803288448316 0.27576816766541684 0.9966676300852221 0.015768320749656166 0.09229316375149148 0.07599546433077999 0.014423069768102315 0.04880966956058033 1.1730951770239449e-07 6.930666750732346 -0.7322647168177432 down GTIK(ub)LADFGLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTIKLADFGLAR 12 1 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 14063500.0 3710900.0 5221400.0 5131200.0 True False 4865025.836406716 4442387.472857795 4600272.645945968 1.0 0.9131272108801215 0.9455803115207516 22.21401603598665 -10.180647755208382 6.6576411674555285 1.0000002478196042 0.9293537613809106 0.8633573598719622 0.013248922856789034 4.87343285472906e-08 6.000884468473436e-09 0.012828259316342681 0.0042760714649608825 6.597087506669305e-11 10.180647755208382 -0.07064648643869353 GTIK(ub)LADFGLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTIKLADFGLAR 12 1 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 30378500.0 6267200.0 5898600.0 18212700.0 True False 6068251.166491834 8253941.740792634 13442247.500711689 1.0 1.36018459261705 2.2151765198741593 22.532849369667375 -6.956562556282265 0.4814438708890161 0.9797540609927804 2.631340797377239 0.999620687633173 0.009925297139527486 0.080952740730339 0.025848350951663025 0.012090669207897154 0.0705262221623525 1.1051912648819695e-07 6.956562556282265 1.6515867363844587 up GTIK(ub)LADFGLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTIKLADFGLAR 12 1 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 16448000.0 3710900.0 4182600.0 8554500.0 True False 5082920.013301765 3997798.901991419 6534103.285457788 1.0 0.7865161937487439 1.2855018903225595 22.27722609750954 -6.79042561225453 1.4944587823799933 0.8807526774719314 1.2908853488455738 0.8027742514329409 0.09078139535056427 0.23470432592898 1.035519690356839 0.0478110128706443 0.11191103335604997 1.6202214883395812e-07 6.79042561225453 0.4101326713736424 GTIK(ub)LADFGLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTIKLADFGLAR 12 1 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 24963900.0 6267200.0 5156500.0 13540200.0 True False 5211454.484035494 5128720.911014887 16371393.217188701 1.0 0.9841246674466698 3.14142496443939 22.31325464510165 -6.905242047735264 0.9275359844731951 0.9227454699609351 3.393602264660813 0.9889985798629732 0.10627636606658572 0.10764881000277432 0.15645931723961445 0.0850127654326773 0.2276116631418188 1.2438211928406946e-07 6.905242047735264 2.470856794699878 up GTIK(ub)LADFGLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTIKLADFGLAR 12 1 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 101949100.0 4397800.0 3088300.0 94463000.0 True False 5693038.793598152 2916433.3901661164 77271703.27223043 1.0 0.5122806107426598 13.573015409472147 22.440767499922895 -6.898223572660977 0.9724151677666839 0.4301993691769817 14.895626568360209 0.9856620452997789 0.7238610279032132 0.1127252320641659 0.18487957530156965 0.5601055523158053 1.4447578551057008 1.2640854349842178e-07 6.898223572660977 14.465427199183226 up GTITVSAQELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTITVSAQELK 11 0 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX55;Q5JX54 Q99829 CPNE1 Copine-1 0 12989800.0 4488400.0 3197600.0 5303800.0 False True 5884335.865727427 2720530.5441471757 4755013.653642083 1.0 0.4623343409054135 0.8080799196621424 22.48844816431775 -10.199585783687127 7.176882115436996 1.0000006570037776 0.6352071302837856 0.59747016452662 0.14115004146287355 1.4839234317959362e-06 1.6543259062035477e-07 0.13666818637737535 0.04555597999184965 6.315594186726155e-11 10.199585783687127 -0.364793526719992 GTITVSAQELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTITVSAQELK 11 0 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX55;Q5JX54 Q99829 CPNE1 Copine-1 0 6492800.0 4488400.0 2004400.0 0.0 False True 6147882.774449229 1915838.9803355809 0.0 1.0 0.31162581503633424 0.0 22.55165822584064 -8.690329737256725 0.4954468166864655 1.0706587549000919 8.9270851153899e-20 0.9946581493407427 0.030535744179910694 0.31507369257029494 0.19016658625262786 0.1067880525307887 0.06238783142523564 2.0401883473696335e-09 8.690329737256725 -1.0706587549000919 GTITVSAQELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTITVSAQELK 11 0 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX55;Q5JX54 Q99829 CPNE1 Copine-1 0 4961090.0 2399500.0 1611600.0 949990.0 False True 1995290.5658736257 1602917.9909224475 1148628.5167425224 1.0 0.8033506589656128 0.5756697978670603 20.928167424754463 -6.969203050674432 0.27655779864633573 1.0522840778955433 0.3198308850319859 0.9999754814978526 0.0008585235828603382 0.07656215981152124 0.009952126459788303 0.004290708196077931 0.020990615802397226 1.0734873951336684e-07 6.969203050674432 -0.7324531928635574 GTITVSAQELK(ub)DNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTITVSAQELKDNR 14 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX55 Q99829 CPNE1 Copine-1 1 5766100.0 1672600.0 1103400.0 2990100.0 True False 1619504.2285349532 1543993.3741549856 2206903.108922783 1.0 0.9533740924849102 1.3627029000839388 20.627120804347328 -6.878568125377973 1.0877016425339099 0.9716112278897532 1.3909328189543952 0.9725142933415091 0.030333009327838098 0.1289084732423513 0.27998567174939903 0.02150834271598877 0.05183090122692591 1.3226102211724121e-07 6.878568125377973 0.41932159106464206 GTITVSAQELK(ub)DNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTITVSAQELKDNR 14 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX55 Q99829 CPNE1 Copine-1 1 3705010.0 1274200.0 611510.0 1819300.0 True False 1745306.1739602538 584491.4662068506 1389618.8096596356 1.0 0.33489336995845714 0.796203457245824 20.73504871573469 -10.163549690077051 5.880153343145641 1.000005241858593 0.5655484136024143 0.5418295485423119 0.18832905450883658 1.2942115906625393e-05 1.840582176250483e-06 0.18235102294873465 0.06078294097663781 6.861993619870264e-11 10.163549690077051 -0.4344568282561787 GTITVSAQELK(ub)DNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTITVSAQELKDNR 14 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX55 Q99829 CPNE1 Copine-1 1 5457800.0 1672600.0 1450100.0 2335100.0 True False 1390841.0087435825 1442288.0234776854 2823358.6137174745 1.0 1.0369898603871175 2.029965032644499 20.407526079781604 -6.914778907168714 0.8625664588511298 0.9737043970066329 2.1723213879968335 0.9926032305639063 0.04102848958081936 0.1013419770701255 0.12225662893671098 0.034405385899972045 0.09843277808442934 1.216805300391171e-07 6.914778907168714 1.1986169909902005 up GTITVSAQELK(ub)DNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTITVSAQELKDNR 14 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX55 Q99829 CPNE1 Copine-1 1 17727000.0 1846600.0 2264400.0 13616000.0 True False 2390460.1019278606 2138384.149432427 11138027.711958012 1.0 0.8945491906381791 4.659365660600402 21.18885689585012 -6.90045467205423 0.9583706606026836 0.8454194911346653 5.058241638081876 0.9867916850906204 0.20117196471897494 0.11107199684824513 0.17553043423749518 0.1572956306127945 0.4102061892939723 1.257608105902428e-07 6.90045467205423 4.212822146947211 up GTK(ub)VILHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTKVILHLK 9 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q14568 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 42782800.0 7506000.0 23348400.0 11928400.0 True False 9840438.688207403 19864909.731350377 10694163.593292387 1.0 2.0187016413359817 1.0867567932828108 23.230291201879936 -6.624973720354843 2.0984720662472003 1.6735653347242987 1.0904058098049423 0.09977915274772464 0.43752378160196775 0.5722021561871938 4.7947818202032275 0.17091019869510393 0.4849262709840003 2.37151720448019e-07 6.624973720354843 -0.5831595249193564 GTK(ub)VILHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTKVILHLK 9 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q14568 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 85782400.0 19600100.0 25088300.0 41094000.0 True False 18977905.55405231 35106189.02375616 30330248.606425524 1.0 1.8498452805430903 1.5981873510772728 24.17781744616413 -10.165109759279215 4.594424350918472 0.9998943415296937 1.7240163158199533 0.9169163594296125 0.10273891951946133 71976189.81380744 16.442124600684103 80453.3765531691 0.035170264841584704 6.83738824075736e-11 10.165109759279215 0.7241219742902596 GTK(ub)VILHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTKVILHLK 9 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q14568 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 250583000.0 45122000.0 72714000.0 132747000.0 True False 68453372.86006469 59737618.582924925 106509497.264923 1.0 0.8726760433710566 1.555942283262715 26.028618292453032 -6.858557844058791 1.193062644016645 0.9311691106464692 1.5881189871394588 0.9518541212174302 0.06509657949078053 0.14829783943154795 0.40193795414005534 0.04258114750412594 0.09923730549000537 1.3849757075233768e-07 6.858557844058791 0.6569498764929895 GTK(ub)VILHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTKVILHLK 9 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q14568 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 43389200.0 7506000.0 18919400.0 16963800.0 True False 10281171.042022983 18083478.34991068 12957299.82042772 1.0 1.7588928611338879 1.260294159825413 23.293501263402828 -10.207669981759812 3.9582868879509037 0.9996525824133617 1.5095935101659927 0.5820770308344947 0.20355206832509148 20145239.5400702 8658591.258249167 62482.52254517974 0.0696812873650591 6.199119641927531e-11 10.207669981759812 0.509940927752631 GTK(ub)VILHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTKVILHLK 9 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q14568 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 74702400.0 19600100.0 40662000.0 14440300.0 True False 16298351.581654342 40442945.73522492 17459699.965596545 1.0 2.481413260267871 1.0712555731862745 23.958222721598407 -6.6346091655237345 2.0638557814182477 1.9726815301047418 1.0770314929627047 0.1343047770609237 0.6347100001113497 0.5470846935784524 4.446755759468671 0.251021391166214 0.7029277973551743 2.3194810807786112e-07 6.6346091655237345 -0.8956500371420371 GTK(ub)VILHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTKVILHLK 9 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q14568 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 199034000.0 45122000.0 85344000.0 68568000.0 True False 58411318.48759283 80594531.37659457 56089327.56709284 1.0 1.379775931503989 0.9602475859024959 25.79974461454548 -6.668292893188932 1.9432018410523109 1.2427588247648653 0.9619463800373589 0.2716263694180514 0.16138321009140358 0.4650332053165897 3.3836427191830327 0.06689572729069848 0.17914194394261357 2.1463824409187634e-07 6.668292893188932 -0.28081244472750644 GTK(ub)VVGAQSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTKVVGAQSLK 11 1 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 3478720.0 763920.0 1249900.0 1464900.0 True False 739669.7777486668 1748991.588142393 1081198.7439420044 1.0 2.3645573210599453 1.461731676036365 19.496521804186344 -10.505751162201562 5.621877815708183 0.9984796929652372 1.913144498548046 0.5769856864693672 0.3685770261678142 0.007032300386227227 0.0006182467711804387 0.35732792317439593 0.11895772367854954 3.1206771269546016e-11 10.505751162201562 0.9146648055828087 GTK(ub)VVGAQSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTKVVGAQSLK 11 1 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 2055170.0 596220.0 867150.0 591800.0 True False 816658.6462396666 828836.4457184174 452029.02850358543 1.0 1.0149117376456172 0.5535103688486848 19.63937364915281 -6.899432382514193 0.9648635602011771 1.0194832978528652 0.5056353857656221 0.9862813783920452 0.02507427312702096 0.11182381340481795 0.17979185389808647 0.01951159877725642 0.05062203287434697 1.2605718873752143e-07 6.899432382514193 -0.5138479120872431 GTK(ub)VVGAQSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTKVVGAQSLK 11 1 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 3669870.0 763920.0 2144600.0 761350.0 True False 635233.3273941148 2133046.614130231 920544.7649153353 1.0 3.3578946855331395 1.4491443147223384 19.27692707962062 -6.593702704275495 2.2150986915625213 2.5921630790101737 1.4549835465171224 0.0028200894162451196 1.0207951026034014 0.6587007377793483 6.0988303627927225 0.38393184465793495 1.136616049614038 2.5485742787997065e-07 6.593702704275495 -1.1371795324930514 GTK(ub)VVGAQSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTKVVGAQSLK 11 1 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 5035500.0 1312100.0 1579800.0 2143600.0 True False 1698539.3153577086 1491882.7412441901 1753486.7951933905 1.0 0.8783327696656835 1.0323498427966091 20.695863181368285 -6.696099834299888 1.844525585204742 0.9241646840230765 1.0318637643382356 0.39923826270867757 0.05139450251260548 0.4036739664982393 2.667224242039113 0.02225094249836291 0.05750604287361688 2.0132613942339843e-07 6.696099834299888 0.10769908031515907 GTKPFKPLEQLMGVFPAASGNFLPPSWR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GTKPFKPLEQLMGVFPAASGNFLPPSWR 28 2 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 0 1385722000.0 590992000.0 349042000.0 445688000.0 False True 896578071.3025873 286752728.0224066 357597571.44800985 1.0 0.3198301823351533 0.39884710868343753 29.739853973176444 -10.55354914789885 6.365831511426742 1.000921717058052 0.35933864551374056 0.9887197764229363 0.03225852509939603 0.00042251667825432353 2.963204536639394e-05 0.0312733860531182 0.010411394206931227 2.79544435701534e-11 10.55354914789885 -0.6415830715443114 GTKPFKPLEQLMGVFPAASGNFLPPSWR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GTKPFKPLEQLMGVFPAASGNFLPPSWR 28 2 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 0 940954000.0 590992000.0 218340000.0 131622000.0 False True 765050794.1939511 206189187.06371474 107668146.5557681 1.0 0.26951045424500647 0.14073333087537807 29.510980295268894 -13.999999999999998 0.24414266879919114 5.934033011483229 0.08599046935366698 0.9995320332053609 0.00818530236087461 13.77335396325355 0.15636830432373947 33.21261377979585 0.06142951449604215 1.0000000000000041e-14 13.999999999999998 -5.848042542129562 GTLAYLPEEYIK(ub)TGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTLAYLPEEYIKTGR 15 1 D3YTB5;P51617-4;P51617-2;P51617-3;P51617;H7C224;H7C2I6 D3YTB5 IRAK1 Interleukin-1 receptor-associated kinase 1 1 14185900.0 3367300.0 3101800.0 7716800.0 True False 3260406.904666828 4340364.915673309 5695538.580962288 1.0 1.3312341197231143 1.7468796832720177 21.63662059596201 -6.968052957611242 0.3010834151380021 0.9288350178882393 2.162322794687176 0.9999629630553373 0.0018595724345265453 0.07693968941621357 0.011279500997911621 0.006858901353320844 0.03723482351048999 1.0763339581036562e-07 6.968052957611242 1.233487776798937 GTLAYLPEEYIK(ub)TGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTLAYLPEEYIKTGR 15 1 D3YTB5;P51617-4;P51617-2;P51617-3;P51617;H7C224;H7C2I6 D3YTB5 IRAK1 Interleukin-1 receptor-associated kinase 1 1 84345600.0 9026300.0 6733300.0 68586000.0 True False 13693557.010921542 5531690.007486986 55029947.03768829 1.0 0.4039629734681126 4.01867440240678 23.706993911060195 -6.864558418317874 1.1624023868388198 0.6717569285607141 4.209660497851228 0.9589490819375202 0.32059544094838904 0.14218425480644561 0.362492770922777 0.2146693334510683 0.5039939423071034 1.3659713222295714e-07 6.864558418317874 3.5379035692905143 up GTLAYLPEEYIK(ub)TGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTLAYLPEEYIKTGR 15 1 D3YTB5;P51617-4;P51617-2;P51617-3;P51617;H7C224;H7C2I6 D3YTB5 IRAK1 Interleukin-1 receptor-associated kinase 1 1 13607400.0 3367300.0 3297200.0 6942900.0 True False 2800059.146683161 3279437.3291570432 8394628.289657425 1.0 1.171202877282694 2.998018202437391 21.417025871396287 -6.92515871994624 0.7855133620324164 0.9666799774861858 3.330656322902821 0.9954982157930767 0.060669427882526654 0.0952305141724121 0.0905741018173287 0.05375632674520949 0.16990689316197205 1.1880679494272494e-07 6.92515871994624 2.3639763454166354 up GTLAYLPEEYIK(ub)TGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTLAYLPEEYIKTGR 15 1 D3YTB5;P51617-4;P51617-2;P51617-3;P51617;H7C224;H7C2I6 D3YTB5 IRAK1 Interleukin-1 receptor-associated kinase 1 1 60498900.0 9026300.0 6984600.0 44488000.0 True False 11684723.284973167 6595900.870043152 36391640.485427976 1.0 0.5644892659568274 3.114463183927384 23.478120233152644 -6.862921519378761 1.170979514403983 0.7616428838915378 3.2449603163750846 0.9570883282349197 0.23070486469427293 0.14381714862266173 0.37308846263259493 0.15348019920201258 0.35950747937078864 1.3711295182748014e-07 6.862921519378761 2.4833174324835467 up GTLDAVLTDEEEK(ub)TLQQVDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTLDAVLTDEEEKTLQQVDR 20 1 Q8N6R0;Q8N6R0-3;Q8N6R0-4;Q8N6R0-1;Q8N6R0-2 Q8N6R0 METTL13 Methyltransferase-like protein 13 1 4039500.0 0.0 4039500.0 0.0 True False 0.0 5652493.4157142155 0.0 0.0 GTLDAVLTDEEEK(ub)TLQQVDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTLDAVLTDEEEKTLQQVDR 20 1 Q8N6R0;Q8N6R0-3;Q8N6R0-4;Q8N6R0-1;Q8N6R0-2 Q8N6R0 METTL13 Methyltransferase-like protein 13 1 9522900.0 0.0 3732200.0 5790700.0 True False 0.0 3712093.897816299 7001508.596828309 0.0 GTLDPVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTLDPVEK 8 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 44793020.0 789020.0 24188000.0 19816000.0 False True 1034412.8608805495 20579244.684085548 17765630.408494163 1.0 19.894614096896817 17.174603178629347 19.980380686759425 -8.97176714882079 13.10059690510684 0.999999999999986 18.534608637763448 0.9822727046733436 1.110439807427068 29212768.623386364 20005970.345229812 1.0751787202821004 0.3801330821056624 1.0671681403708072e-09 8.97176714882079 17.534608637763462 GTLDPVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTLDPVEK 8 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 53747300.0 16502000.0 5231300.0 32014000.0 False True 15978153.042738108 7320185.370869112 23628573.000586607 1.0 0.4581371420895267 1.4788050244221143 23.929597317153245 -6.76246792026199 1.6029662383090495 0.6862144287531978 1.4830194043886082 0.7009817872743724 0.22799942098965365 0.27882285609074087 1.4125180592230007 0.11219036467078759 0.2689813445772965 1.727953613379752e-07 6.76246792026199 0.7968049756354104 GTLDPVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTLDPVEK 8 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 59188020.0 789020.0 28031000.0 30368000.0 False True 1080742.016463759 26792497.733878743 23195703.848592203 1.0 24.790835671907264 21.462757526990288 20.043590748282316 -9.61427647432262 9.41300012029916 1.0000000025783655 23.126795084483344 0.983315843941974 1.358682213193069 0.0 0.0 1.315538396122008 0.43851279870733595 2.430656146991445e-10 9.61427647432262 22.12679508190498 GTLDPVEK(ub)ALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTLDPVEKALR 11 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 13614900.0 4150300.0 5329600.0 4135000.0 True False 5441083.491562377 4534444.454618093 3707149.8657207987 1.0 0.8333715999119969 0.6813256718941306 22.375462535553005 -6.972218253279016 0.19816300973848905 1.0926745817484234 0.41783301099205267 0.99999490701922 0.00029364665571432854 0.07558923762608775 0.006384009253178714 0.005011879695252361 0.016217346448751595 1.066060241483017e-07 6.972218253279016 -0.6748415707563706 GTLDPVEK(ub)ALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTLDPVEKALR 11 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 25161800.0 6546900.0 12065000.0 6549900.0 True False 6339072.243091872 16882617.41814381 4834284.697211911 1.0 2.6632631354756953 0.7626170694741912 22.59584027905292 -6.675532208295708 1.9182563045987429 2.0565746980455843 0.7701627994578354 0.30364143887050354 0.705631450565813 0.4484908574260412 3.1868343873424956 0.2956285234653112 0.7840500225245216 2.110900640669037e-07 6.675532208295708 -1.2864118985877488 GTLDPVEK(ub)ALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTLDPVEKALR 11 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 43437800.0 14707500.0 6383700.0 22346600.0 True False 22312352.762275647 5244478.858924252 17929784.715137288 1.0 0.23504822260569913 0.8035810882952632 24.41133931313655 -10.17007444584236 7.206094054538043 1.0000005027351795 0.519314655453813 0.487999704899425 0.23210257049028563 1.874743281268865e-06 2.1586011660484465e-07 0.2247325836029899 0.07491078251006744 6.75967092609477e-11 10.17007444584236 -0.48068584728136654 GTLDPVEK(ub)ALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTLDPVEKALR 11 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 14900000.0 4150300.0 3928300.0 6821400.0 True False 5684778.067640288 3754734.716849063 5210325.811142879 1.0 0.6604892349663225 0.9165398805631209 22.438672597075897 -10.324845125781453 5.5828863605831955 1.0000359722447134 0.7885145577647191 0.47632867911950816 0.10453223833707044 4.681154385209264e-05 5.660925311097077e-06 0.10123009954183956 0.033737634851770205 4.7332002002599465e-11 10.324845125781453 -0.21152141447999429 GTLDPVEK(ub)ALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTLDPVEKALR 11 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 16288800.0 6546900.0 6411200.0 3330700.0 True False 5444037.426846433 6376661.593076435 4027133.9705831897 1.0 1.1713111231805478 0.7397329692709308 22.376245554487195 -6.799004115272703 1.459888705648342 1.0946437488079337 0.7339165490866776 0.8292246062933711 0.07332465619288836 0.22220426867757437 0.9350474952521275 0.03951351473174854 0.09195372067234858 1.5885316959724931e-07 6.799004115272703 -0.3607271997212561 GTLDPVEK(ub)ALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTLDPVEKALR 11 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 43805700.0 14707500.0 29098200.0 0.0 True False 19039148.67816746 27478859.59062645 0.0 1.0 1.4432819479022694 0.0 24.182465635229 -6.848541744571213 1.4095412227977357 1.2361402467227793 2.1672797011248772e-21 0.8930767022002526 0.19738894161567028 0.17597917264513466 0.7025026343037041 0.11256098596132384 0.23821755107954792 1.4172884745214347e-07 6.848541744571213 -1.2361402467227793 down GTLEQWIEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTLEQWIEKR 10 1 P19525-2;P19525 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 1 52573000.0 14226000.0 17694000.0 20653000.0 True False 18650423.764779978 15054124.170671798 18516025.6775651 1.0 0.8071733039707366 0.9927938319841999 24.152705075196124 -10.647459746688329 8.131763124467515 1.0001359244316217 0.8999835679836165 0.27907434881074844 0.07577926323649598 0.00018699138378042087 8.106748384892904e-06 0.07347220227917786 0.024457652041901413 2.2518541239445107e-11 10.647459746688329 -0.10015235644800524 GTLEQWIEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTLEQWIEKR 10 1 P19525-2;P19525 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 1 45594000.0 12327000.0 6029000.0 27238000.0 True False 11935686.13245865 8436411.140819661 20103550.67751541 1.0 0.7068224689552751 1.6843230003212433 23.508778167492803 -6.826295213676409 1.3442953769529284 0.8428948209459528 1.7087054443161218 0.8982663218284712 0.13063658965409153 0.18543583492239302 0.6566560947579756 0.07632598616674846 0.1757061618677757 1.4917800205033707e-07 6.826295213676409 0.865810623370169 GTLEQWIEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTLEQWIEKR 10 1 P19525-2;P19525 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 1 45562000.0 14226000.0 10689000.0 20647000.0 True False 19485736.64319464 10216724.636203863 15770603.838312803 1.0 0.5243181114105859 0.8093409105896266 24.215915136719016 -10.289782490252012 5.911623260223485 1.0000210925057325 0.6668295110001061 0.6456225363735106 0.11636007050807226 3.234947906955236e-05 3.886610240263409e-06 0.11267227643371606 0.037555051270106485 5.1311830710308385e-11 10.289782490252012 -0.33319158150562633 GTLEQWIEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTLEQWIEKR 10 1 P19525-2;P19525 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 1 28186100.0 12327000.0 5394100.0 10465000.0 True False 10250446.678693121 5365040.912654979 12653183.115307014 1.0 0.5233958168678552 1.234403095975153 23.28918344292708 -6.726060653798076 1.7373426455491865 0.7119324353713844 1.2337035590118308 0.5409950791022083 0.20042316190087484 0.34368680946937863 2.030366947038825 0.09148457433007212 0.22805400462409411 1.87905436874543e-07 6.726060653798076 0.5217711236404464 GTLEQWIEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTLEQWIEKR 10 1 P19525-2;P19525 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 1 72100000.0 19875000.0 31645000.0 20580000.0 True False 25728579.29482088 29883927.93180933 16834651.16863218 1.0 1.1615071158563706 0.6543171690797932 24.616868459374775 -6.821057489392939 1.3673099151657035 1.0869615863694417 0.6429940943786411 0.8867810096295576 0.07118613441794765 0.1921214046310771 0.7054781366368185 0.040909201655490994 0.09426276078107833 1.5098802717127646e-07 6.821057489392939 -0.44396749199080066 GTLK(ub)GHNGWVTQIATTPQFPDMILSASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTLKGHNGWVTQIATTPQFPDMILSASR 28 1 P63244;J3KPE3;D6RAC2;D6REE5;D6RHH4;D6RBD0;D6RFZ9;E9PD14;D6RAU2;D6RGK8;D6R909;D6RHJ5;D6RDI0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 18159500.0 6466400.0 5294800.0 6398300.0 True False 6261127.6715284 7409041.252017235 4722393.285114423 1.0 1.183339749756072 0.7542400559229681 22.577991089038996 -6.790609985180044 1.4938778171623799 1.1023893441643757 0.7495991408930931 0.8032790688212634 0.07797119017990478 0.23445594244700804 1.0336396698658397 0.04108081737678412 0.09613839828108266 1.6195337946485557e-07 6.790609985180044 -0.35279020327128263 GTLLGESLK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTLLGESLKLK 11 1 O75663;O75663-2 O75663 TIPRL TIP41-like protein 1 4127920.0 873720.0 1062500.0 2191700.0 True False 845984.2368501475 1486761.7908643025 1617628.020409371 1.0 1.75743438955785 1.912125486442022 19.69027125642271 -11.063271299203626 0.2962894811699396 1.5516546532507366e-12 1.9593819193528101 0.9992589032328357 0.010849876483278348 3.006071588830499 0.15310872204783185 2.0880416028763835 0.05657331134700331 8.644277511333527e-12 11.063271299203626 1.9593819193512585 GTLSGWILSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTLSGWILSK 10 0 P27824;P27824-2;H0Y9Q7;D6RAQ8;D6RAU8;D6RB85;D6RDP7 P27824 CANX Calnexin 0 108830000.0 33229000.0 31941000.0 43660000.0 False True 43563540.790093705 27175527.305042807 39142482.016292736 1.0 0.6238135562943609 0.8985147053334491 25.376617883479994 -10.454761176343558 5.42749020565829 1.0002623138224471 0.7611641308139037 0.501966907419813 0.11214627448367125 0.00035635165718098495 3.579859670563694e-05 0.10870324953503131 0.03619505445120468 3.509448095877606e-11 10.454761176343558 -0.23909818300854346 GTLSGWILSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTLSGWILSK 10 0 P27824;P27824-2;H0Y9Q7;D6RAQ8;D6RAU8;D6RB85;D6RDP7 P27824 CANX Calnexin 0 42586700.0 17661000.0 5933700.0 18992000.0 False True 17100361.222142626 8303057.353836718 14017425.452212812 1.0 0.4855486528018716 0.8197151668388248 24.027523464637895 -10.146049042344027 5.351678102918269 1.0000093480124013 0.6526319098202196 0.5902921491977711 0.1364229080863189 1.5216332432982837e-05 2.4279300766329876e-06 0.13209446579922088 0.0440303042548911 7.144156467261324e-11 10.146049042344027 -0.3473774381921817 GTLSGWILSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTLSGWILSK 10 0 P27824;P27824-2;H0Y9Q7;D6RAQ8;D6RAU8;D6RB85;D6RDP7 P27824 CANX Calnexin 0 73077000.0 33229000.0 18531000.0 21317000.0 False True 45514659.2799602 17712239.14617773 16282363.637395937 1.0 0.3891546026353824 0.35773888885432026 25.439827945002886 -13.692982899854552 0.4255493731319024 9.999999999999922 0.3569098036776229 0.999866615024836 0.0034143939321071154 23.48594574953044 0.2179904657293346 195.086261706316 0.007519625758802259 2.0277625601674545e-14 13.692982899854552 -9.6430901963223 GTLSGWILSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTLSGWILSK 10 0 P27824;P27824-2;H0Y9Q7;D6RAQ8;D6RAU8;D6RB85;D6RDP7 P27824 CANX Calnexin 0 28543900.0 17661000.0 5938800.0 4944100.0 False True 14685904.014958967 5906806.505640497 5977888.451064443 1.0 0.4022092545085316 0.4070494022686928 23.80792874007217 -10.010820520717752 5.567989789707144 1.0000018494652592 0.4046293283881734 0.9999504337788249 0.001975982050225271 4.53667378513078e-08 8.059307944041437e-09 0.0019132423499304393 0.0006377454641859275 9.753926513670623e-11 10.010820520717752 -0.5953725210770857 GTLSGWILSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTLSGWILSK 10 0 P27824;P27824-2;H0Y9Q7;D6RAQ8;D6RAU8;D6RB85;D6RDP7 P27824 CANX Calnexin 0 10511500.0 1628400.0 3777700.0 5105400.0 False True 2107995.900562836 3567467.6741348137 4176269.585827732 1.0 1.6923503851133193 1.9811564077105968 21.007440630680982 -10.480026418634088 0.18758063611812842 7.483099751218622e-19 2.2551925854957613 0.9994620895193286 0.009548369631496136 2.2232721660148655 0.096138227494645 1.2299076780372875 0.19375157304614768 3.3111097900731906e-11 10.480026418634088 2.2551925854957613 GTLTLCPYHSDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTLTLCPYHSDR 12 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 13396700.0 5062200.0 3854300.0 4480200.0 False True 6636593.222414532 3279253.4639437306 4016631.881113026 1.0 0.49411698955246036 0.6052249620403419 22.662011418966983 -9.762399435051666 6.163980759481128 1.0000000105921447 0.5496709757957563 0.9563380359675533 0.045359639827601585 6.603208623060894e-09 1.380248983091493e-09 0.04391928306390503 0.014639760803152586 1.7282261210967573e-10 9.762399435051666 -0.4503290347963884 GTLTLCPYHSDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTLTLCPYHSDR 12 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 14614200.0 5062200.0 3480700.0 6071300.0 False True 6933832.140811178 3326911.1648643226 4637383.982348454 1.0 0.4798084374270867 0.6688053428714722 22.725221480489875 -10.084674158678157 5.04062884717811 1.000010358068542 0.5743068901477264 0.8712053186873931 0.0771576635560254 8.981571760550071e-06 1.630956267596493e-06 0.07470940275397621 0.02490252883129061 8.228597914849851e-11 10.084674158678157 -0.4257034679208156 GTLVQTK(ub)GTGASGSFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTLVQTKGTGASGSFK 16 1 P10412;Q02539;P16401;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1B;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1.5;Histone H1.3;Histone H1.2 1 8852500.0 2144800.0 4090700.0 2617000.0 True False 2811853.570272746 3480383.505423715 2346217.944036601 1.0 1.2377541783180845 0.8344026050435553 21.42309003608816 -6.7469911551324655 1.6610649546472156 1.1403079961743783 0.8337860524106374 0.6358675001030467 0.09989460098523316 0.30533315690067936 1.6565813212663612 0.04752734771868186 0.11574659102064257 1.7906423219931478e-07 6.7469911551324655 -0.30652194376374087 GTLVQTK(ub)GTGASGSFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTLVQTKGTGASGSFK 16 1 P10412;Q02539;P16401;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1B;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1.5;Histone H1.3;Histone H1.2 1 18903450.0 3298300.0 8186650.0 7418500.0 True False 3193597.2718981435 11455622.037815772 5475372.29977046 1.0 3.5870590630255075 1.7144842738784416 21.6067509627032 -6.5627329594658566 2.3349029254811056 2.779616302540919 1.717658811718999 0.0 1.1287887814057163 0.7529678320740647 7.696030669697965 0.410442019742449 1.2688964927435815 2.7369511152435836e-07 6.5627329594658566 -1.0619574908219198 GTLVQTK(ub)GTGASGSFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTLVQTKGTGASGSFK 16 1 P10412;Q02539;P16401;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1B;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1.5;Histone H1.3;Histone H1.2 1 10941700.0 2987100.0 3499900.0 4454700.0 True False 4531649.086261673 2875315.500156486 3574226.5924356333 1.0 0.6344965034634756 0.7887253678294289 22.111604717969133 -10.15401852649212 5.260345134156031 1.0000102287898325 0.7116109367486749 0.8233815249776526 0.06296367021813304 7.553431056841354e-06 1.2148277577493391e-06 0.06096647272619306 0.020321437180831188 7.014253757996812e-11 10.15401852649212 -0.28839929204115755 GTLVQTK(ub)GTGASGSFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTLVQTKGTGASGSFK 16 1 P10412;Q02539;P16401;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1B;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1.5;Histone H1.3;Histone H1.2 1 7403300.0 2144800.0 2541600.0 2716900.0 True False 2937790.521040619 2429303.708052736 2075224.176311912 1.0 0.826915224436163 0.7063894315980126 21.48630009761105 -6.974997439863674 0.06958879789294818 1.518511288020545 0.011783067119393548 0.9999999411548981 2.8656165577983136e-05 0.0747123999888001 0.002008223199437932 0.017234499515406426 0.02611236025909854 1.0592599694241001e-07 6.974997439863674 -1.5067282209011514 GTLVQTK(ub)GTGASGSFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTLVQTKGTGASGSFK 16 1 P10412;Q02539;P16401;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1B;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1.5;Histone H1.3;Histone H1.2 1 18853900.0 3298300.0 13848800.0 1706800.0 True False 2742682.5894648796 13774193.76562844 2063683.988648448 1.0 5.022161083654927 0.7524326717847033 21.387156238137475 -6.659659748117877 1.9742021447903808 3.5897631390383253 0.7702852288378598 0.23411696425250672 1.712688602470468 0.48525013504334447 3.635331682001121 0.7010020140164211 1.8984033065341708 2.189476316898405e-07 6.659659748117877 -2.8194779102004657 GTMTTGHNVADLVVILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTMTTGHNVADLVVILK 17 0 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 12699400.0 3726900.0 6670900.0 2301600.0 False True 4886001.991350944 5675627.722964531 2063452.5105061678 1.0 1.1616097850576728 0.42231921193622723 22.22022302091779 -6.849420600931577 1.2377676166450537 1.0862066394645518 0.3930760908231499 0.9394680036182804 0.07807773506200008 0.15810126989211568 0.4663904390481058 0.04936463726680173 0.11419925644943932 1.4144232907003174e-07 6.849420600931577 -0.6931305486414019 down GTMTTGHNVADLVVILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTMTTGHNVADLVVILK 17 0 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 24455200.0 8448100.0 7804100.0 8203000.0 False True 8179919.689756136 10920317.827843852 6054388.215274934 1.0 1.335015286460522 0.7401525253184277 22.963655248217442 -6.753926194014566 1.635614629456665 1.1960601889280955 0.7386283775567206 0.6655870828172492 0.1408106045127304 0.2932377279472239 1.544640197214832 0.06797914455371175 0.1643410179990313 1.7622755101041908e-07 6.753926194014566 -0.4574318113713749 GTMTTGHNVADLVVILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTMTTGHNVADLVVILK 17 0 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 121039000.0 20263000.0 63291000.0 37485000.0 False True 30740452.42372877 51996226.55516 30076073.319740847 1.0 1.6914593786207177 0.9783874649979099 24.87363506231331 -6.653221308378947 1.9975538154344032 1.4475478402434132 0.9814112064069673 0.2070875909838934 0.2948913061728596 0.5006294934553916 3.8327698462881856 0.11959073964851868 0.32659033350816413 2.2221772219597365e-07 6.653221308378947 -0.4661366338364459 GTMTTGHNVADLVVILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTMTTGHNVADLVVILK 17 0 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 16663500.0 3726900.0 6067100.0 6869500.0 False True 5104835.645685514 5799035.460783271 5247065.581793472 1.0 1.1359886709936446 1.0278618051549155 22.28343308244068 -10.313853375382397 4.282296291998258 0.9999055710177847 1.0819252380749103 0.43356657671330945 0.04414260813600948 3.984468969583978e-05 6.384326973292781e-06 0.04279012950189993 0.014246965513502607 4.8545236881954696e-11 10.313853375382397 0.0820196670571256 GTMTTGHNVADLVVILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTMTTGHNVADLVVILK 17 0 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 17702700.0 8448100.0 4069100.0 5185500.0 False True 7024969.464287121 4047178.9506468843 6269764.074956947 1.0 0.5761133868583418 0.892496986190557 22.74406052365172 -10.293363966046986 5.779603938210751 1.0000218930170532 0.7343051865244483 0.4846218358831662 0.12916306355818666 3.644005880819914e-05 4.455534992638168e-06 0.12507189206146407 0.0416871995088314 5.0890419861837355e-11 10.293363966046986 -0.2657167064926049 GTPFETPDQGK(ub)AR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTPFETPDQGKAR 13 1 F8VXD5;Q53FV1;J3KTF9;F6WST4;A0A1B0GXE7;J3QRM9;Q8N138-4;Q9P0S3;Q8N138 F8VXD5 ORMDL2;ORMDL3;ORMDL1 ORM1-like protein 2;ORM1-like protein 3;ORM1-like protein 1 1 43534600.0 1945000.0 2819600.0 38770000.0 True False 1883257.0396391707 3945480.9840197572 28614973.92493108 1.0 2.0950305247634735 15.194406988869488 20.844798491477544 -6.923439316766902 0.7988068731590511 0.7451942256570027 17.483440252344376 0.9950840226275806 0.45214577863020833 0.09619063229749213 0.09543732409627234 0.3968389390514854 1.2307840910292391 1.1927809194720415e-07 6.923439316766902 16.738246026687374 up GTPFETPDQGK(ub)AR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTPFETPDQGKAR 13 1 F8VXD5;Q53FV1;J3KTF9;F6WST4;A0A1B0GXE7;J3QRM9;Q8N138-4;Q9P0S3;Q8N138 F8VXD5 ORMDL2;ORMDL3;ORMDL1 ORM1-like protein 2;ORM1-like protein 3;ORM1-like protein 1 1 112210000.0 3639000.0 30129000.0 78442000.0 True False 5520629.0465355115 24752244.551048566 62937904.31765 1.0 4.4835913339589295 11.400495086179877 22.39640123317755 -6.960186490579366 0.43280103688570803 0.733274502993686 15.417292541237208 0.9997770446431332 0.06454092490872301 0.0796346181266046 0.020885979357288233 0.09044769073654924 0.5739532356977115 1.0960074580488087e-07 6.960186490579366 14.684018038243522 GTPFETPDQGK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTPFETPDQGKAR 13 1 F8VXD5;Q53FV1;J3KTF9;F6WST4;A0A1B0GXE7;J3QRM9;Q8N138-4;Q9P0S3;Q8N138 F8VXD5 ORMDL2;ORMDL3;ORMDL1 ORM1-like protein 2;ORM1-like protein 3;ORM1-like protein 1 1 39295100.0 1945000.0 4647100.0 32703000.0 True False 1617353.6781096868 4622065.149922867 39541046.098412305 1.0 2.8577949353198955 24.447989721473082 20.62520376691182 -6.923860837136344 0.7955614231715543 0.586596751042901 28.258856182684138 0.9951880517475032 0.7382623329033371 0.09595302488966721 0.0942285482832976 0.6494606157759768 2.0234700489021473 1.1916237840322655e-07 6.923860837136344 27.672259431641237 GTPFETPDQGK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTPFETPDQGKAR 13 1 F8VXD5;Q53FV1;J3KTF9;F6WST4;A0A1B0GXE7;J3QRM9;Q8N138-4;Q9P0S3;Q8N138 F8VXD5 ORMDL2;ORMDL3;ORMDL1 ORM1-like protein 2;ORM1-like protein 3;ORM1-like protein 1 1 134792000.0 3639000.0 19403000.0 111750000.0 True False 4710757.235413996 18323205.993392233 91412646.65182918 1.0 3.8896519344372313 19.405085442445976 22.16752755527 -6.938228893267208 0.6758397262548964 0.819355382004791 23.37974912865438 0.9979225924301668 0.36835279701495127 0.08858402787622419 0.05835937819358107 0.35392322588978153 1.3461361128348048 1.1528454948095584e-07 6.938228893267208 22.56039374664959 GTPGVAGPSGEPGMPGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTPGVAGPSGEPGMPGK 17 0 Q14050 Q14050 COL9A3 Collagen alpha-3(IX) chain 0 30113500.0 10576000.0 5404500.0 14133000.0 False True 13865238.418129679 4598169.666576002 12670652.733308846 1.0 0.33163293179031117 0.9138431198371002 23.72496908850065 -10.478574700606366 8.78970732703747 1.0000098507037531 0.6227380258137443 0.35890928183895665 0.23768631396074583 4.588384422746932e-05 2.721852859979035e-06 0.23014478301933575 0.0767129279659497 3.322196370229052e-11 10.478574700606366 -0.3772718248900089 GTPGVAGPSGEPGMPGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTPGVAGPSGEPGMPGK 17 0 Q14050 Q14050 COL9A3 Collagen alpha-3(IX) chain 0 22189000.0 4184200.0 3952800.0 14052000.0 False True 4051374.861315287 5531173.653579689 10371359.64903614 1.0 1.365258422861414 2.5599605082381975 21.949980148680797 -6.949492898007569 0.564381991085983 0.9847186157168144 2.9980283257609672 0.9991608952504244 0.019297538390101947 0.08368998468549686 0.036809822495916994 0.020578066551338828 0.0994094555806241 1.1233293392635475e-07 6.949492898007569 2.013309710044153 up GTPGVAGPSGEPGMPGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTPGVAGPSGEPGMPGK 17 0 Q14050 Q14050 COL9A3 Collagen alpha-3(IX) chain 0 16873200.0 3338300.0 7293200.0 6241700.0 False True 5064445.162420866 5991671.477968314 5008025.259165705 1.0 1.1830854685578671 0.9888596082205002 22.271972791900485 -6.659456463496288 1.9744290920115384 1.117898282146332 0.9896630669952574 0.23349620521988046 0.07796288687623232 0.4857069559115381 3.6392161471303544 0.0319051422297511 0.08644194072504294 2.1905014071713097e-07 6.659456463496288 -0.1282352151510745 GTPGVAGPSGEPGMPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTPGVAGPSGEPGMPGK 17 0 Q14050 Q14050 COL9A3 Collagen alpha-3(IX) chain 0 32268000.0 10576000.0 11639000.0 10053000.0 False True 14486233.005653469 11124750.494973961 7678688.448034032 1.0 0.767953303707897 0.530067992488959 23.78817915002354 -6.970814487679886 0.23792922748961098 1.087641756273955 0.20351661426716539 0.9999880561337512 0.0006630199172738665 0.07603928116947815 0.008078480111297569 0.0057706801406224445 0.02327782208578606 1.0695116320087471e-07 6.970814487679886 -0.8841251420067897 GTPGVAGPSGEPGMPGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTPGVAGPSGEPGMPGK 17 0 Q14050 Q14050 COL9A3 Collagen alpha-3(IX) chain 0 12302400.0 4184200.0 3979000.0 4139200.0 False True 3479347.691489236 3957564.3372303336 5004687.582501549 1.0 1.1374443396130987 1.4383982361818617 21.730385424115074 -6.958235096407575 0.45963198324824867 0.9911954196556311 1.5967717029039177 0.9996990361168662 0.0031760846745080284 0.0803377010459678 0.023507106729639522 0.004084743643397127 0.024862820155524223 1.1009431752030306e-07 6.958235096407575 0.6055762832482866 GTQGVVTNFEIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTQGVVTNFEIFR 13 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 41030000.0 11620000.0 15894000.0 13516000.0 False True 15233932.528240085 13522677.154326765 12117493.974626921 1.0 0.8876681795235039 0.7954278353382471 23.860785075284852 -6.973379164315314 0.15781043996734906 1.096207208166082 0.5844461995584973 0.9999981739318363 0.0001128909814137308 0.0752206584470076 0.004860687834409079 0.004360105721874336 0.011159647894071246 1.0632143649855484e-07 6.973379164315314 -0.5117610086075848 GTQGVVTNFEIFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTQGVVTNFEIFR 13 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 41337000.0 11300000.0 8906000.0 21131000.0 False True 10941287.685307281 12462212.244176444 15596157.183588294 1.0 1.139007820890366 1.4254407371567328 23.383279203793904 -6.959457315111806 0.4430167266771321 0.9900746159094359 1.5855976497817195 0.9997495358046196 0.0028032218784764637 0.07989555863117377 0.0218520107324407 0.0037910708973866673 0.023719643288173962 1.0978491877233726e-07 6.959457315111806 0.5955230338722836 GTQGVVTNFEIFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTQGVVTNFEIFR 13 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 86630000.0 13722000.0 46641000.0 26267000.0 False True 20817277.21257496 38317549.14220371 21075315.936764926 1.0 1.8406609447972127 1.0123954118281182 24.31127804846871 -10.27433544929149 4.674384059319753 0.9998270530451917 1.4265281783138546 0.26122165232840255 0.3381379878888463 0.0006096875148851413 9.465012857910037e-05 0.3275322927837624 0.10913356631722279 5.3169741724876454e-11 10.27433544929149 0.4267011252686629 GTQGVVTNFEIFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTQGVVTNFEIFR 13 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 38362000.0 11620000.0 12294000.0 14448000.0 False True 15916228.018692661 11750810.429178618 11035679.965900298 1.0 0.7382911588963158 0.6933602580297009 23.923995136807743 -13.999999999448479 0.24790190686439306 2.8009932047357657 0.674930233788623 0.9995387885575638 0.0029037641607161453 13.915705255251897 0.15755495066210212 12.464646748592596 0.020979899514000845 1.0000000012699252e-14 13.999999999448479 -2.126062970947143 GTQGVVTNFEIFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTQGVVTNFEIFR 13 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 31222900.0 11300000.0 10786000.0 9136900.0 False True 9396450.674878914 10727893.677146615 11047383.54574761 1.0 1.1416963754013276 1.1756974977032986 23.16368447922818 -13.999999999999806 0.200488868138129 0.21086105527372073 1.197673318208502 0.9994869515461685 0.001723412178325787 12.539991629750068 0.14196835071284752 3.8813556974525696 0.021570417984999323 1.0000000000004459e-14 13.999999999999806 0.9868122629347813 GTQGVVTNFEIFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTQGVVTNFEIFR 13 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 64250000.0 13722000.0 33506000.0 17022000.0 False True 17763399.501058213 31641361.64585889 13924170.660469241 1.0 1.7812672424540095 0.7838685753613627 24.08240437056116 -6.69776466113579 1.8386599426251093 1.4862028342841 0.7869442581023688 0.40696422371597973 0.3299213828156306 0.40024185277806745 2.6289607827618156 0.14322934131761544 0.36939267632467393 2.005558520575219e-07 6.69776466113579 -0.6992585761817313 GTQSLPTASASK(ub)FPSSGPVTPQPTALTFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTQSLPTASASKFPSSGPVTPQPTALTFAK 30 1 Q9Y679 Q9Y679 AUP1 Ancient ubiquitous protein 1 1 27952700.0 10417000.0 11597000.0 5938700.0 True False 13656787.878371488 9866772.804751942 5324220.292032917 1.0 0.7224812227169564 0.3898588994316141 23.70311486109864 -6.96871702000074 0.28718089128434604 1.0672229962904947 0.03488068632135785 0.9999705737608007 0.0013530307335228894 0.07672123346045613 0.010512891679951475 0.0059007228325720674 0.030263451092511096 1.074689436337443e-07 6.96871702000074 -1.032342309969137 down GTQSLPTASASK(ub)FPSSGPVTPQPTALTFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTQSLPTASASKFPSSGPVTPQPTALTFAK 30 1 Q9Y679 Q9Y679 AUP1 Ancient ubiquitous protein 1 1 27885500.0 10414000.0 8506500.0 8965000.0 True False 10083413.270335406 11903189.810811482 6616797.55576495 1.0 1.180472275774882 0.656206125680779 23.265480742994242 -6.813793877556801 1.39877950497101 1.097922936300187 0.6462389917659106 0.8694405250229204 0.07857668145934193 0.20167542714589326 0.776998176781671 0.044164284302793115 0.10198468546343728 1.5353455070880364e-07 6.813793877556801 -0.4516839445342764 GTQSLPTASASK(ub)FPSSGPVTPQPTALTFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTQSLPTASASKFPSSGPVTPQPTALTFAK 30 1 Q9Y679 Q9Y679 AUP1 Ancient ubiquitous protein 1 1 23559900.0 10417000.0 7090300.0 6052600.0 True False 14268446.408840032 6777027.1015133485 4623100.537209866 1.0 0.4749660129300856 0.32400868354844986 23.766324922621532 -13.999999999999938 0.17479646389300824 3.6826464165752792 0.1974258133979206 0.9995053469310898 0.006443490168400707 12.141836443924085 0.1324768585710215 11.051164325043462 0.11789994238470948 1.0000000000001431e-14 13.999999999999938 -3.4852206031773587 GTQSLPTASASK(ub)FPSSGPVTPQPTALTFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTQSLPTASASKFPSSGPVTPQPTALTFAK 30 1 Q9Y679 Q9Y679 AUP1 Ancient ubiquitous protein 1 1 23628200.0 10414000.0 9387300.0 3826900.0 True False 8659702.418423811 9336728.75166683 4627087.096413607 1.0 1.0781812469447707 0.5343240301848389 23.04588601842852 -6.870428648895695 1.1317712768513462 1.0443370712523556 0.5022050371820593 0.9651118951800916 0.04484306277036983 0.13644736615535685 0.3263873504982426 0.030740724012379324 0.07283757217316411 1.3476321123182177e-07 6.870428648895695 -0.5421320340702963 GTQTYSVLEGDPSENYSK(ub)YLLSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTQTYSVLEGDPSENYSKYLLSLK 24 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 18416000.0 3462400.0 6490300.0 8463300.0 True False 3352488.007221942 9081910.636467364 6246507.8364423225 1.0 2.7090061521183904 1.8632453935662328 21.676800740543445 -10.021122844099141 5.8685067034261955 0.9999976840217321 2.2861257728425155 0.7550978163951881 0.3452803838210616 1.0462426109081871e-05 1.7461675255235692e-06 0.33431689652787727 0.11143876469248408 9.525266951742845e-11 10.021122844099141 1.2861280888207833 GTQTYSVLEGDPSENYSK(ub)YLLSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTQTYSVLEGDPSENYSKYLLSLK 24 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 58724900.0 6389900.0 13715000.0 38620000.0 True False 9693945.46426415 11267451.094215905 30986740.07225271 1.0 1.1623183909742778 3.196504476581028 23.208652535606394 -6.922778301454926 0.8038621633786268 0.959451365166226 3.5464446957344493 0.9949183624691816 0.0712416012195174 0.09656434644059256 0.09734761147669954 0.06230299634743428 0.19188298645507787 1.1945977668281946e-07 6.922778301454926 2.586993330568223 up GTQTYSVLEGDPSENYSK(ub)YLLSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTQTYSVLEGDPSENYSKYLLSLK 24 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 17615900.0 3462400.0 4521100.0 9632400.0 True False 2879139.010327501 4496743.936931918 11646490.304814456 1.0 1.5618363409345821 4.045129555411662 21.45720601597772 -6.942588425455423 0.6350256949506834 0.972885419561486 4.769074352638301 0.9984836689993485 0.051521437938344794 0.08660535622808656 0.04937923721226129 0.051196827669648066 0.21141536680950496 1.1413308978450448e-07 6.942588425455423 3.796188933076815 GTSELDRPLQGTLTLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTSELDRPLQGTLTLLR 17 1 V9GZ20;V9GXZ5;Q70EL4-2;Q70EL4-3;Q70EL4-4;Q70EL4 V9GZ20 USP43 Ubiquitin carboxyl-terminal hydrolase 43 0 36495100.0 4339100.0 13460000.0 18696000.0 False True 5688602.119904177 11451820.466669057 16761517.264695575 1.0 2.0131167948272606 2.946508986108861 22.43964274690895 -6.972107341163868 0.20159748127946803 0.45574649020262264 4.529694863754529 0.9999944900568858 0.0018658368085262115 0.0756246566378287 0.0065221461504215835 0.029909522633929642 0.098694185899454 1.0663325316010808e-07 6.972107341163868 4.073948373551906 GTSELDRPLQGTLTLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTSELDRPLQGTLTLLR 17 1 V9GZ20;V9GXZ5;Q70EL4-2;Q70EL4-3;Q70EL4-4;Q70EL4 V9GZ20 USP43 Ubiquitin carboxyl-terminal hydrolase 43 0 62154000.0 16236000.0 29038000.0 16880000.0 False True 15720597.067137064 40633024.831169546 12458621.610854695 1.0 2.584699846808641 0.7925030809993008 23.906152676301684 -6.673324870295131 1.9257216593030984 2.0085997893516656 0.7996504505735786 0.29384053169715907 0.6726337789162327 0.4535029047333519 3.2454303744579036 0.2808919381548338 0.7471974512359764 2.121656780930402e-07 6.673324870295131 -1.208949338778087 GTSELDRPLQGTLTLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTSELDRPLQGTLTLLR 17 1 V9GZ20;V9GXZ5;Q70EL4-2;Q70EL4-3;Q70EL4-4;Q70EL4 V9GZ20 USP43 Ubiquitin carboxyl-terminal hydrolase 43 0 88595000.0 37941000.0 32869000.0 17785000.0 False True 57559270.85864357 27003270.143330846 14269786.95455757 1.0 0.4691385026340342 0.2479146580852614 25.77854498083315 -11.34504742908101 0.1619337612176574 2.1365727865574082 7.899432737253648e-15 0.9995683233778128 0.006557003904111562 3.8582593335497646 0.09842668730919835 1.7568187871097847 0.18606097873887725 4.518066001099462e-12 11.34504742908101 -2.1365727865574002 GTSELDRPLQGTLTLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTSELDRPLQGTLTLLR 17 1 V9GZ20;V9GXZ5;Q70EL4-2;Q70EL4-3;Q70EL4-4;Q70EL4 V9GZ20 USP43 Ubiquitin carboxyl-terminal hydrolase 43 0 25552100.0 4339100.0 11017000.0 10196000.0 False True 5943382.529768444 10530232.511652905 7787914.793211478 1.0 1.771757489764531 1.3103505881043969 22.502852808431843 -10.238065490469426 4.347760603815985 0.9997366509236613 1.5410540389466463 0.6470643003246013 0.1883685788520738 0.0004810783772776274 8.430783050492238e-05 0.18247456057037856 0.0607956973978393 5.7800887860974946e-11 10.238065490469426 0.541317388022985 GTSELDRPLQGTLTLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTSELDRPLQGTLTLLR 17 1 V9GZ20;V9GXZ5;Q70EL4-2;Q70EL4-3;Q70EL4-4;Q70EL4 V9GZ20 USP43 Ubiquitin carboxyl-terminal hydrolase 43 0 50193600.0 16236000.0 25060000.0 8897600.0 False True 13500953.376755212 24924996.805979475 10758047.02214578 1.0 1.8461656825578856 0.7968360990467581 23.68655795173596 -6.692115329363428 1.858840202698933 1.5294505048586222 0.8003721781748302 0.3802793995099487 0.3577191276534082 0.4121912455854413 2.7629514325803344 0.1538547470795909 0.3995922245715918 2.0318173786567545e-07 6.692115329363428 -0.729078326683792 GTSELDRPLQGTLTLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTSELDRPLQGTLTLLR 17 1 V9GZ20;V9GXZ5;Q70EL4-2;Q70EL4-3;Q70EL4-4;Q70EL4 V9GZ20 USP43 Ubiquitin carboxyl-terminal hydrolase 43 0 78366000.0 37941000.0 24737000.0 15688000.0 False True 49115372.428920716 23360364.204429373 12832944.972473348 1.0 0.4756222552976924 0.26128163827007644 25.5496713029256 -12.080407698217876 0.14944991087702367 2.44955193089847 1.2488759053577666e-11 0.9996047562555856 0.006169146661596976 5.612706562579773 0.10228014916747463 2.730204977422582 0.2069666229411278 8.309833110684749e-13 12.080407698217876 -2.449551930885981 GTSEQETK(ub)GLPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTSEQETKGLPSK 13 1 E9PCN5;Q9H9A5-4;Q9H9A5-3;Q9H9A5-2;Q9H9A5;Q9H9A5-6;Q9H9A5-5 E9PCN5 CNOT10 CCR4-NOT transcription complex subunit 10 1 2255540.0 684530.0 673470.0 897540.0 True False 937619.2397276826 643713.8685325295 685559.5374165395 1.0 0.6865408059667019 0.7311705097003449 19.838642648265797 -10.145488489298181 6.770721937825921 1.00000047691514 0.7088556578337137 0.9826816915756945 0.018220000253168823 1.3117395712736497e-07 1.655920968682403e-08 0.017641468171282784 0.005880479795701428 7.15338353416777e-11 10.145488489298181 -0.2911448190814263 GTSFDAAATSGGSASSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTSFDAAATSGGSASSEK 18 0 P13804;P13804-2;H0YL12;H0YLU7;H0YNX6;H0YKF0;H0YK49 P13804 ETFA Electron transfer flavoprotein subunit alpha, mitochondrial 0 5428650.0 942650.0 1995600.0 2490400.0 False True 1235823.2786355866 1697864.2587878725 2232717.2976036486 1.0 1.373873019014825 1.8066638945891074 20.237041023517648 -6.969205738077655 0.2765008509157065 0.9005466268125322 2.2931156375576887 0.9999755066809678 0.001631262631547386 0.07656129041230882 0.00994917253760928 0.008158794861957936 0.03990329115708118 1.0734807524414871e-07 6.969205738077655 1.3925690107451565 GTSFDAAATSGGSASSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTSFDAAATSGGSASSEK 18 0 P13804;P13804-2;H0YL12;H0YLU7;H0YNX6;H0YKF0;H0YK49 P13804 ETFA Electron transfer flavoprotein subunit alpha, mitochondrial 0 6241050.0 942650.0 2832400.0 2466000.0 False True 1291173.1791584026 2707255.2025057347 1883581.588864213 1.0 2.0967405815154447 1.458814060939484 20.30025108504054 -10.157450687129097 4.7204096605205 0.9999593715062842 1.7777773212088204 0.6646568097857501 0.26043241258124555 137816912.9756708 19.264952726817132 122787.06730670178 0.09530850372343797 6.95903968079184e-11 10.157450687129097 0.7778179497025361 GTSPSSK(ub)YVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTSPSSKYVK 10 1 Q9H3F6;F5GWA4;Q9H3F6-2;F5H6V0;F5H497;F8W8I7 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 43901300.0 8569300.0 21028000.0 14304000.0 True False 11234435.285219235 17890704.366502013 12823959.293656683 1.0 1.592488087945124 1.1414867741976074 23.421424271445005 -10.320607391009291 5.479576580206086 0.9999305187919272 1.3669874310713739 0.468889432876482 0.1841205153344088 0.0001563147022319517 1.9381067128044174e-05 0.17830753802930752 0.05942464079877021 4.7796116276284676e-11 10.320607391009291 0.3670569122794467 GTSPSSK(ub)YVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTSPSSKYVK 10 1 Q9H3F6;F5GWA4;Q9H3F6-2;F5H6V0;F5H497;F8W8I7 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 51565000.0 14033000.0 21344000.0 16188000.0 True False 13587530.09627585 29866770.507489618 11947877.170409681 1.0 2.1981015163069024 0.8793266388925554 23.695779895026206 -6.667512007233801 1.9458888174522806 1.766348548087638 0.8846718311730065 0.2682403568085229 0.5092162434732407 0.4668304400581252 3.4053292031619393 0.2108392161537228 0.5652059121988764 2.1502452292316604e-07 6.667512007233801 -0.8816767169146315 GTSPSSK(ub)YVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTSPSSKYVK 10 1 Q9H3F6;F5GWA4;Q9H3F6-2;F5H6V0;F5H497;F8W8I7 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 18695500.0 6579700.0 4334300.0 7781500.0 True False 9981885.94050281 3560810.3009595345 6243483.114247391 1.0 0.35672720788273893 0.6254813119947245 23.250880988089335 -10.379406282351637 5.926408588821004 1.0001068407374465 0.4911042599387991 0.8270088120869441 0.1097184035588668 0.00015491719310361794 1.6222618732780063e-05 0.10625646160128319 0.03541146247966271 4.1743966924678606e-11 10.379406282351637 -0.5090025807986474 GTSPSSK(ub)YVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTSPSSKYVK 10 1 Q9H3F6;F5GWA4;Q9H3F6-2;F5H6V0;F5H497;F8W8I7 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 38869300.0 8569300.0 13809000.0 16491000.0 True False 11737601.786625022 13198872.719743565 12596165.44280604 1.0 1.1244948465353168 1.0731464290396484 23.484634332967897 -10.02828913449414 5.651957019956712 0.9999996817420382 1.0988206377875218 0.8316024145060525 0.020962903660770044 8.405626901200105e-08 1.4448571035519415e-08 0.020297309521122808 0.006765748063839217 9.369380263994573e-11 10.02828913449414 0.09882095604548358 GTSPSSK(ub)YVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTSPSSKYVK 10 1 Q9H3F6;F5GWA4;Q9H3F6-2;F5H6V0;F5H497;F8W8I7 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 39477800.0 14033000.0 18606000.0 6838800.0 True False 11669061.267307594 18505765.78499817 8268761.46096145 1.0 1.5858829910204089 0.7086055400298111 23.476185170460482 -6.726720585812331 1.7352108975859177 1.3538688340545426 0.7094367053010402 0.5439516895756346 0.24636196919524572 0.34243862427052035 2.018402965994695 0.1125835602427712 0.28040918952913 1.8762012206954381e-07 6.726720585812331 -0.6444321287535024 GTSPSSK(ub)YVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTSPSSKYVK 10 1 Q9H3F6;F5GWA4;Q9H3F6-2;F5H6V0;F5H497;F8W8I7 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 11012300.0 6579700.0 3031000.0 1401600.0 True False 8517551.355277132 2862322.185536868 1146523.1816304591 1.0 0.3360498887703786 0.13460713458688095 23.022007310181785 -11.90104861059203 0.2050274469720872 2.5295292580586617 1.1109364783187904e-20 0.9993781460115202 0.009219997647314036 5.041992846579659 0.12747950996137583 3.421633855844935 0.12166414779036984 1.2558893840978646e-12 11.90104861059203 -2.5295292580586617 GTSQIK(ub)LLSSEDIEGMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTSQIKLLSSEDIEGMR 17 1 P53582 P53582 METAP1 Methionine aminopeptidase 1 1 31228900.0 4321400.0 4373500.0 22534000.0 True False 5594137.487528999 4130110.8803845206 18433043.218365304 1.0 0.7382927018851019 3.29506438829186 22.415484280796267 -6.88166660175192 1.0704963176693056 0.833945178508856 3.4821270895669714 0.9750035877456213 0.1815916421859894 0.1261624221879217 0.2634713393709511 0.13047354326128294 0.31688809821451214 1.3132076325560183e-07 6.88166660175192 2.6481819110581153 up GTTITLVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTTITLVLK 9 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 157880000.0 43542000.0 59714000.0 54624000.0 False True 57083983.661327854 50804903.963348955 48972032.47040704 1.0 0.8900027766942143 0.8578944448052538 25.766582682415198 -13.999999999994369 0.172633922449097 1.558647767598177 0.8303510428105001 0.9995088918996918 0.00134847836364601 12.118225793668389 0.13162126524234438 2.267734300690763 0.025562824692626496 1.000000000012966e-14 13.999999999994369 -0.7282967247876768 GTTITLVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTTITLVLK 9 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 293007000.0 133630000.0 73949000.0 85428000.0 False True 129387988.7953639 103477221.33894052 63051844.01493451 1.0 0.7997436416033712 0.4873083243812946 26.947128455952896 -6.9645952720885855 0.36493171662182144 1.0254503464411024 0.25081223440977796 0.999904557259358 0.0020610491475731327 0.07809857210255647 0.01534583817189334 0.004152662200658175 0.026609311260222913 1.0849375185130507e-07 6.9645952720885855 -0.7746381120313245 down GTTITLVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTTITLVLK 9 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 1355520000.0 346510000.0 525720000.0 483290000.0 False True 525681003.274257 431901158.530892 387767519.66646844 1.0 0.8216031316344935 0.7376479599818511 28.9696123597549 -13.999999999999904 0.10043921931763802 1.8798965396740863 0.5600437334331156 0.9997915128996038 0.0015795316930984338 12.077066231485329 0.09446993446586112 2.200170265229585 0.15835959376660935 1.0000000000002209e-14 13.999999999999904 -1.3198528062409707 GTTITLVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTTITLVLK 9 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 262074000.0 43542000.0 56472000.0 162060000.0 False True 59640654.078306 53976880.31206888 123784765.73046817 1.0 0.9050350159003825 2.07550986224838 25.82979274393809 -6.887244609650371 1.0385764636339487 0.9328918902256661 2.1708988249168244 0.9790740807779121 0.0767846367901777 0.12140591343745069 0.23515100455307952 0.05652780920149573 0.13959279762858345 1.296448860536543e-07 6.887244609650371 1.2380069346911582 up GTTITLVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTTITLVLK 9 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 240122000.0 133630000.0 41889000.0 64603000.0 False True 111119265.8127495 41663335.6426845 78111188.60947715 1.0 0.3749425028859772 0.7029491064232256 26.727533731387172 -10.604572339972066 6.64422989803542 1.001087526121 0.5389458046546816 0.7248494910915078 0.13390813515493974 0.002161702232009895 0.00012865219716148436 0.1299257719277363 0.043218664781397804 2.4855795093974333e-11 10.604572339972066 -0.4621417214663184 GTTITLVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTTITLVLK 9 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 1138480000.0 346510000.0 469710000.0 322260000.0 False True 448564025.73325217 443570225.5917259 263611986.6668324 1.0 0.9888671407980988 0.5876797325329756 28.74073868184735 -6.912841644026836 0.8761473801287449 1.0113332961288715 0.5325512330779187 0.9919507260026557 0.01720781392154366 0.10256917241724463 0.12879180660959635 0.014289259656074053 0.04026711081419984 1.222245243888679e-07 6.912841644026836 -0.4787820630509527 GTTLQSLGLTGGSATIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTTLQSLGLTGGSATIR 17 0 Q9BZE9;Q9BZE9-2;J3QL04;Q9BZE9-3;J3QR12;Q9BZE9-4 Q9BZE9 ASPSCR1 Tether containing UBX domain for GLUT4 0 12349500.0 4125300.0 3902000.0 4322200.0 False True 5408308.249462029 3319836.809876868 3874980.205469999 1.0 0.613840161608225 0.7164865659895492 22.366745950473994 -10.083759568691516 7.310769334959474 1.0000000670518128 0.6651633637988891 0.9341579807445638 0.04190521911093808 4.577839849360806e-08 5.789072568685913e-09 0.040574561793811234 0.013524851311319655 8.245944953554254e-11 10.083759568691516 -0.3348367032529237 GTTLQSLGLTGGSATIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTTLQSLGLTGGSATIR 17 0 Q9BZE9;Q9BZE9-2;J3QL04;Q9BZE9-3;J3QR12;Q9BZE9-4 Q9BZE9 ASPSCR1 Tether containing UBX domain for GLUT4 0 13258200.0 3583800.0 1300400.0 8374000.0 False True 3470034.230672939 1819656.5014964156 6180598.185384902 1.0 0.5243915133204701 1.7811346443652536 21.726518463879444 -6.804161092987605 1.438824705016835 0.7389539809302373 1.8003262323204237 0.8440607352183933 0.20459028289978373 0.21487129882722764 0.877711892672961 0.111839610482677 0.259471550308798 1.5697804171880318e-07 6.804161092987605 1.0613722513901864 GTTLQSLGLTGGSATIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTTLQSLGLTGGSATIR 17 0 Q9BZE9;Q9BZE9-2;J3QL04;Q9BZE9-3;J3QR12;Q9BZE9-4 Q9BZE9 ASPSCR1 Tether containing UBX domain for GLUT4 0 12603300.0 4125300.0 2353900.0 6124100.0 False True 5650534.892040688 2249896.914693636 4677713.709798593 1.0 0.39817414770110143 0.827835558787115 22.429956011996886 -10.294579483988697 5.889634091948863 1.0000271042127997 0.6130048532441494 0.5196177767285916 0.17540853655416097 6.243200133192761e-05 7.477874719911379e-06 0.16985045721682404 0.05661286173807267 5.074818518869556e-11 10.294579483988697 -0.3870222509686503 GTTLQSLGLTGGSATIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTTLQSLGLTGGSATIR 17 0 Q9BZE9;Q9BZE9-2;J3QL04;Q9BZE9-3;J3QR12;Q9BZE9-4 Q9BZE9 ASPSCR1 Tether containing UBX domain for GLUT4 0 7402200.0 3583800.0 1953700.0 1864700.0 False True 2980088.4892593836 1943175.030320915 2254600.148601338 1.0 0.652052795520792 0.7565547656477994 21.50692373931372 -10.44143074504585 8.754547040233836 1.0000038091226282 0.704303780584296 0.9143493173730326 0.04266275065445648 3.1718472639124665e-06 2.0242948502365586e-07 0.04130856228219422 0.013769343565675803 3.618838941004505e-11 10.44143074504585 -0.2957000285383322 GTTVTPDK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTTVTPDKR 9 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 19059000.0 7115300.0 7903700.0 4040000.0 True False 9328227.204663208 6724498.768381307 3621979.5544164516 1.0 0.7208763917134984 0.38828166112911716 23.153171497554794 -6.968800154701138 0.2853939933834394 1.0686730256936774 0.03027475740588174 0.9999714513350685 0.0013360326588739116 0.07669399610697003 0.010417086804899731 0.00595872998206878 0.030325633318645687 1.0744837338999133e-07 6.968800154701138 -1.0383982682877957 down GTTVTPDK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTTVTPDKR 9 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 17454300.0 5665900.0 7936100.0 3852300.0 True False 5486039.105856859 11105026.116214782 2843267.0634772205 1.0 2.024233860155887 0.5182732037840867 22.387333475437575 -6.723547883589704 1.7463348853007772 1.620746298260094 0.5201024856006692 0.529313057783781 0.4308239633973831 0.34846354794942963 2.078661757991995 0.1957340829944794 0.48936700015075774 1.8899578404319708e-07 6.723547883589704 -1.100643812659425 GTTVTPDK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTTVTPDKR 9 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 14903500.0 7115300.0 5201600.0 2586600.0 True False 9746018.693752468 4971776.112609039 1975698.3526991778 1.0 0.5101340628246607 0.2027185063748819 23.216381559077686 -8.429876274832926 0.27121943425737255 1.199939477391386 1.4753930363531338e-17 0.9991738399913727 0.009436824568682556 0.13861585845547558 0.06969374090818212 0.11708536305876795 0.10353788367005357 3.7164109000199093e-09 8.429876274832926 -1.199939477391386 down GTTVTPDK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTTVTPDKR 9 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 13260300.0 5665900.0 5515800.0 2078600.0 True False 4711446.891928887 5486085.290599427 2513225.649639478 1.0 1.1644162433407796 0.5334296888594562 22.16773875087185 -6.837494622246436 1.2939880152950485 1.0875134394442747 0.5136853379064269 0.9200596482617059 0.07556514557257793 0.1717446406537989 0.5596888594619964 0.04580920876278402 0.10547484628934026 1.4538023875461886e-07 6.837494622246436 -0.5738281015378478 GTTVTPDKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTTVTPDKR 9 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 0 8959000.0 1768500.0 1956800.0 5233700.0 False True 1712359.9355279568 2738160.444577192 3862836.962365528 1.0 1.5990565930479792 2.2558557241498023 20.70755455530491 -6.969943609076985 0.25952954622999636 0.8145407590142767 3.0598458440394984 0.9999819395148635 0.0021796174278012233 0.07632100762477247 0.009095598448056734 0.013752613512672636 0.06201383941597874 1.0716584455864022e-07 6.969943609076985 2.2453050850252216 GTTVTPDKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTTVTPDKR 9 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 0 8151100.0 1768500.0 4353200.0 2029400.0 False True 1470586.1078339245 4329748.447557451 2453738.157114574 1.0 2.9442332036815464 1.6685443606758719 20.487959830739186 -10.091787138117713 4.794873686788705 0.9999501348093237 2.3063887821870024 0.5830344862193014 0.5207977893904115 181112740.8745325 15.61820441395679 115410.7614195108 0.1782829357068147 8.094925606531042e-11 10.091787138117713 1.3064386473776786 GTVHIFALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTVHIFALK 9 0 Q9Y484-2;Q9Y484-3;Q9Y484;A0A0U1RR06;H0Y329;A0A0U1RQR1;C9J0A8;C9JYH8;G8JLI5;A0A0U1RQM7;A0A0U1RQG6;A0A0U1RRJ9;A6NM71;H7C4N7 Q9Y484-2 WDR45 WD repeat domain phosphoinositide-interacting protein 4 0 10484900.0 2100500.0 3261700.0 5122700.0 False True 2753775.8412709325 2775067.074007018 4592652.144408208 1.0 1.0077316506365526 1.6677654279545828 21.392979697479475 -6.909458473562612 0.8994185857034631 0.9792122168015986 1.7520818575379875 0.9907154539057657 0.03015772447283349 0.10477726923702942 0.14071942821967454 0.02462457866191271 0.06772228814700795 1.231803762909434e-07 6.909458473562612 0.7728696407363889 GTVIIIANHGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTVIIIANHGDR 12 0 A0A087WYS1;E7EUC7;Q16851-2;Q16851 A0A087WYS1 UGP2 UTP--glucose-1-phosphate uridylyltransferase 0 25961700.0 10346500.0 7656400.0 7958800.0 False True 13564361.69564852 6514094.964413451 7135299.722200421 1.0 0.48023601187980625 0.5260328412275708 23.693317823870444 -10.056475576789275 7.680815888232634 1.000000028132128 0.5031344276078662 0.9936686560757776 0.018696477289890205 8.999374248527754e-09 1.088729343561556e-09 0.018102787373128135 0.00603426209804083 8.780604647738152e-11 10.056475576789275 -0.49686560052426176 GTVIIIANHGDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTVIIIANHGDR 12 0 A0A087WYS1;E7EUC7;Q16851-2;Q16851 A0A087WYS1 UGP2 UTP--glucose-1-phosphate uridylyltransferase 0 21331380.0 6426700.0 2935580.0 11969100.0 False True 6222687.926297725 4107772.4028474665 8834033.644696726 1.0 0.6601283001012462 1.4196491531196964 22.56910646483885 -6.785044273484965 1.5160047912895176 0.8088174600288459 1.4266688031133876 0.7849042625338059 0.14407117088302254 0.2428119868761968 1.1024454455505073 0.0748246664105573 0.17584121984479342 1.6404225343155616e-07 6.785044273484965 0.6178513430845417 GTVIIIANHGDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTVIIIANHGDR 12 0 A0A087WYS1;E7EUC7;Q16851-2;Q16851 A0A087WYS1 UGP2 UTP--glucose-1-phosphate uridylyltransferase 0 20441300.0 3702400.0 11803500.0 4935400.0 False True 5616811.48169637 9697073.203833558 3959916.026737336 1.0 1.726437363161222 0.7050113822836326 22.42131995155601 -6.715728650305495 1.774816276338754 1.4439679600283655 0.7069890625773453 0.4922024105916841 0.30585926323669593 0.3636970824798679 2.2365635658074283 0.13696497159552964 0.34555561849431654 1.9242936631509992e-07 6.715728650305495 -0.7369788974510202 GTVIIIANHGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTVIIIANHGDR 12 0 A0A087WYS1;E7EUC7;Q16851-2;Q16851 A0A087WYS1 UGP2 UTP--glucose-1-phosphate uridylyltransferase 0 21777500.0 10346500.0 5281200.0 6149800.0 False True 14171880.653649172 5047859.121407033 4697343.8991067 1.0 0.35618837363742833 0.33145522559118945 23.756527885393336 GTVIIIANHGDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTVIIIANHGDR 12 0 A0A087WYS1;E7EUC7;Q16851-2;Q16851 A0A087WYS1 UGP2 UTP--glucose-1-phosphate uridylyltransferase 0 11751500.0 6426700.0 3356400.0 1968400.0 False True 5344085.801083568 3338318.407006764 2379983.3391467086 1.0 0.6246753011207055 0.44534901342043254 22.349511740273126 -13.999999999999995 0.09788056947784511 2.8656614470853765 0.050536150945138074 0.999804287084537 0.0032330223994445797 12.096910614855535 0.09273587469763815 4.584203675569242 0.35257475967653135 1.0000000000000123e-14 13.999999999999995 -2.8151252961402387 GTVIIIANHGDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTVIIIANHGDR 12 0 A0A087WYS1;E7EUC7;Q16851-2;Q16851 A0A087WYS1 UGP2 UTP--glucose-1-phosphate uridylyltransferase 0 20377500.0 3702400.0 12253800.0 4421300.0 False True 4792829.785214836 11571865.258044096 3616668.7663689707 1.0 2.4144118979024816 0.7545998769924719 22.19244627364846 -6.680976473906774 1.8982029839013612 1.8941126200919918 0.7608336225700881 0.3287085995421656 0.5993308355714633 0.4363486613246652 3.040552136522595 0.2532591542112195 0.6671721537708099 2.084603804760307e-07 6.680976473906774 -1.1332789975219035 GTVMYVGLTDFKPGYWIGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTVMYVGLTDFKPGYWIGVR 20 1 Q99426;K7EP07;Q99426-2 Q99426 TBCB Tubulin-folding cofactor B 0 24048400.0 14288000.0 2703300.0 7057100.0 False True 13834435.260855785 3782741.7875232683 5208633.80153807 1.0 0.27342943287511334 0.3764977538530813 23.721760416725214 -10.52874782386595 6.432586703516002 1.0006279957635418 0.3249635933640973 0.9828157963913292 0.04207746584023616 0.00037927992597359375 2.7786085352684885e-05 0.04077568816955623 0.013580443704153844 2.959730555979312e-11 10.52874782386595 -0.6756644023994445 GTVMYVGLTDFKPGYWIGVR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GTVMYVGLTDFKPGYWIGVR 20 1 Q99426;K7EP07;Q99426-2 Q99426 TBCB Tubulin-folding cofactor B 0 473883000.0 185122000.0 125591000.0 163170000.0 False True 280843608.23103815 103178304.80303828 130919377.98004837 1.0 0.3673870502267506 0.46616470570463026 28.065191727839462 -10.822050135170127 7.376873539941477 1.02838715232765 0.4167758779657001 0.9789397412131805 0.0403258089848728 0.01601905584815145 0.0003864218782552586 0.03322205666190663 0.01301509888506281 1.5064331527592154e-11 10.822050135170127 -0.61161127436195 GTVMYVGLTDFKPGYWIGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTVMYVGLTDFKPGYWIGVR 20 1 Q99426;K7EP07;Q99426-2 Q99426 TBCB Tubulin-folding cofactor B 0 27164700.0 14288000.0 6318800.0 6557900.0 False True 11881105.065722996 6284759.3702164 7929126.569696306 1.0 0.5289709446596798 0.6673728180867491 23.50216569215949 -10.642315098833 9.915677998178428 1.0001141174396477 0.5981718813732206 0.9182953208312585 0.056502328223597006 0.00014258156055706604 5.14327956295804e-06 0.05472330969698982 0.01823604801932805 2.2786881883897523e-11 10.642315098833 -0.4019422360664271 GTVMYVGLTDFKPGYWIGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GTVMYVGLTDFKPGYWIGVR 20 1 Q99426;K7EP07;Q99426-2 Q99426 TBCB Tubulin-folding cofactor B 0 357639600.0 185122000.0 101490000.0 71027600.0 False True 239644078.30016774 95841992.28311992 58101305.60472008 1.0 0.3999347405658504 0.24244832593753857 27.83631804993191 -13.999999999999984 0.1877878908650256 4.192513331738408 0.12691645122755935 0.9994907780217146 0.007365262469303145 12.315528444619588 0.13741834428029145 14.376361090453937 0.11024151621940201 1.0000000000000368e-14 13.999999999999984 -4.065596880510849 GTVSFHSHSDHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTVSFHSHSDHR 12 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 39104800.0 7798800.0 11616000.0 19690000.0 False True 10224302.323686639 9882938.078813374 17652667.679816816 1.0 0.9666124656660019 1.726540072951568 23.285499065471654 -6.89662327918678 0.982355772424058 0.9654103789599257 1.8010590328660372 0.9848100773719274 0.04321409245280465 0.11393520600722333 0.19176465125560793 0.033190573727608315 0.08498338359655519 1.2687519443598074e-07 6.89662327918678 0.8356486539061115 GTVSFHSHSDHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTVSFHSHSDHR 12 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 17496900.0 4543900.0 2183000.0 10770000.0 False True 4399656.381705106 3054683.2841946078 7949013.906925642 1.0 0.6943004223913395 1.8067351668597733 22.068959421308588 -6.833434471187677 1.3123900652914324 0.8369979352583617 1.8388477070493725 0.9125868583246344 0.13873798081046257 0.17661214907521144 0.5936766091443944 0.0829687197417929 0.1909510548848417 1.4674574885052597e-07 6.833434471187677 1.0018497717910106 GTVSFHSHSDHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTVSFHSHSDHR 12 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 28742800.0 7798800.0 10005000.0 10939000.0 False True 10682227.114645464 9562946.017889371 8355433.495776821 1.0 0.8952202490413684 0.7821808510625485 23.348709126994546 -6.970158265710585 0.25440560645144 1.0339841072261369 0.640087637539134 0.9999835782199121 0.00036039510342317953 0.07625157819914492 0.008847541970201218 0.0024477820510681926 0.010757469449538396 1.0711288930288296e-07 6.970158265710585 -0.39389646968700287 GTVSFHSHSDHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTVSFHSHSDHR 12 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 10168000.0 4543900.0 3400600.0 2223500.0 False True 3778454.178901084 3382280.2928337483 2688423.569697574 1.0 0.8951492151791668 0.7115141384298772 21.849364696742864 -6.962555693527546 0.39778772316188893 1.0103442985791964 0.5896378357375459 0.9998535406886778 0.001442900196728996 0.0788006039848231 0.01784903161034265 0.0023637421498855023 0.015398483069890065 1.0900446970857249e-07 6.962555693527546 -0.4207064628416505 GTVVTGTLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTVVTGTLER 10 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 86665000.0 26440000.0 28486000.0 31739000.0 False True 34663096.045324184 24235999.837558337 28454952.74198614 1.0 0.6991873953171476 0.8209004961582052 25.046897183388012 -10.06114908907649 4.854847895024162 1.0000066397746992 0.7600439459354402 0.8382494467351218 0.04968916535506696 3.571143495528308e-06 6.905424147170722e-07 0.04811265853821665 0.016037109157552742 8.686621748096916e-11 10.06114908907649 -0.23996269383925894 GTVVTGTLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTVVTGTLER 10 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 35572000.0 11609000.0 0.0 23963000.0 False True 11240478.649445314 0.0 17686371.425409388 1.0 0.0 1.573453584761905 23.422200134866305 -6.734998904456215 1.7051202446614977 0.4015802874985725 1.573387942230629 0.5822469610502237 0.4202360954129955 0.3269358538762878 1.8643695105342861 0.19513689817196012 0.48148124951496346 1.840776644974581e-07 6.734998904456215 1.1718076547320564 GTVVTGTLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTVVTGTLER 10 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 99882000.0 13467000.0 70322000.0 16093000.0 False True 20430423.56957783 57772489.671706244 12912211.496187538 1.0 2.8277675925296557 0.6320089963976382 24.284215778972584 -6.685758592881997 1.881340143217957 2.150404821305054 0.6399306349390718 0.35071936873751985 0.7736932315303783 0.4258479738317266 2.9188385280633122 0.32939365159505 0.8624246814822201 2.0617756543088046e-07 6.685758592881997 -1.5104741863659825 GTVVTGTLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTVVTGTLER 10 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 69546000.0 26440000.0 14776000.0 28330000.0 False True 36215582.514133655 14123147.462302182 21639037.47466468 1.0 0.3899743282270945 0.5975062658793279 25.110107244910903 -10.294220959777041 5.0122593595444425 1.0001468323544662 0.4937402970530738 0.888073405022223 0.08472455876383221 0.00013905768826947233 1.9580711845837862e-05 0.08205775396273707 0.02734473375883074 5.079009676245356e-11 10.294220959777041 -0.5064065353013925 GTVVTGTLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTVVTGTLER 10 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 23103000.0 11609000.0 11494000.0 0.0 False True 9653397.865899926 11432079.54061963 0.0 1.0 1.1842544666062915 0.0 23.20260541030058 -6.921851709791364 1.2555779090214452 1.0973182220942397 1.52091616063518e-18 0.9601276633507689 0.10389379922882475 0.12126822293355181 0.3824344151663246 0.06810667012952916 0.1327606133672636 1.1971492291187162e-07 6.921851709791364 -1.0973182220942397 down GTVVTGTLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTVVTGTLER 10 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 46502000.0 13467000.0 20280000.0 12755000.0 False True 17433296.97425674 19151400.17244726 10433720.87735198 1.0 1.0985529702572954 0.5984938415699087 24.055342101065033 -6.8555220695662396 1.2081180821722217 1.0529565276872093 0.5762655139515164 0.9479664575630193 0.0493344923037843 0.15148515800654647 0.4227030395596246 0.031902449756152536 0.0741352438195377 1.3946907817620634e-07 6.8555220695662396 -0.4766910137356929 GTVYFK(ub)EGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTVYFKEGK 9 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 1 4973700.0 1225400.0 1920400.0 1827900.0 True False 1186500.3477500472 2687225.7347537023 1349118.1541754291 1.0 2.2648334995008392 1.1370566866952487 20.178281092693958 -6.618689756797303 2.1222362820513436 1.8400584489494858 1.14138898042939 0.07816683004532343 0.5441129446133105 0.5889494130439009 5.038896785570796 0.21083771186920627 0.6031661754040496 2.406080997553611e-07 6.618689756797303 -0.6986694685200958 GTVYFK(ub)EGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTVYFKEGK 9 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 1 5311600.0 1520100.0 1495900.0 2295600.0 True False 2306102.8341958304 1228944.9574799526 1841873.653802779 1.0 0.5329098682229851 0.7986953688667858 21.137025416692218 -10.177140828580036 5.512830962797726 1.0000097211920826 0.6658026185448476 0.6782555290714722 0.10850647626804935 1.2964615642648075e-05 1.935147714680865e-06 0.10506399822876475 0.03502031462846409 6.650574631889672e-11 10.177140828580036 -0.3342071026472351 GTWVQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTWVQLK 7 0 P46778 P46778 RPL21 60S ribosomal protein L21 0 57456700.0 7521700.0 10071000.0 39864000.0 False True 9861021.540246403 8568446.056450525 35739255.682489514 1.0 0.8689207321452034 3.624295468438504 23.23330567786531 -6.895732530174837 0.9878606124278142 0.8716465401339759 3.889701457079723 0.9843206738972319 0.15891668744751233 0.11461475998610152 0.19566738064430872 0.12155628443400823 0.31001016001259035 1.2713568572776476e-07 6.895732530174837 3.018054916945747 up GTYIHALDNGLFTLGAPHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTYIHALDNGLFTLGAPHK 19 0 Q14331;E9PRR7 Q14331 FRG1 Protein FRG1 0 14274900.0 3003300.0 5513100.0 5758500.0 False True 4113701.1711307764 5269513.01261629 4398460.900030238 1.0 1.2809664079629302 1.0692222689625233 21.97200556625312 -10.342434575563084 3.2675917480339667 0.9987588909438159 1.175094338528651 0.47691005793644003 0.08644418436919124 53680288.869779006 70216837.45966513 634222.4542804277 0.03163532673562127 4.545330053281978e-11 10.342434575563084 0.1763354475848351 GTYLATFHQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GTYLATFHQR 10 0 P55884;P55884-2;C9JQN7 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 20105900.0 6268800.0 5295700.0 8541400.0 False True 8218457.507145552 4505602.202476925 7657617.862894245 1.0 0.5482296645762933 0.9317585272219655 22.970436214373184 -10.099188476745157 7.416408828580557 1.00000005422464 0.7399940958991295 0.37995505228673465 0.15657500251864545 1.4025211666329506e-07 1.7057788419263506e-08 0.15160312592351796 0.050534364765591526 7.958139051660172e-11 10.099188476745157 -0.26000595832551043 GTYLATFHQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GTYLATFHQR 10 0 P55884;P55884-2;C9JQN7 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 13329150.0 4862000.0 898650.0 7568500.0 False True 4707658.471324244 1257485.6313978403 5586082.799866921 1.0 0.26711488079637924 1.186594744264781 22.16657822963272 -6.694415746055133 1.8509639797428679 0.542428394400374 1.1835730917550489 0.3910147512386507 0.3096887997132769 0.4072710203064097 2.7086725129957157 0.13368672562236772 0.34617375238451675 2.0210834879524338e-07 6.694415746055133 0.6411446973546748 GTYLATFHQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GTYLATFHQR 10 0 P55884;P55884-2;C9JQN7 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 12274800.0 3729600.0 4739600.0 3805600.0 False True 5658075.870282728 3893781.349336179 3053421.4919462646 1.0 0.6881811836046678 0.5396572195122736 22.431880091577387 -13.999999999995405 0.09840557150478212 2.5474041353163157 0.21534981566210004 0.9998016781145109 0.002701544050552822 12.092814662353842 0.09309502318545909 3.815903982662798 0.289516881538178 1.0000000000105813e-14 13.999999999995405 -2.332054319654216 GTYLATFHQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GTYLATFHQR 10 0 P55884;P55884-2;C9JQN7 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 14032800.0 6268800.0 3014100.0 4749900.0 False True 8586544.767950123 2880927.0957041834 3628071.447261206 1.0 0.33551645901357724 0.42252984702336094 23.033646275896075 -10.700121995889125 6.823157948334109 1.0055841928554472 0.3790231530208367 0.9854877797720601 0.03552306690246299 0.0030214238669406942 0.00013279144599144595 0.034438925457451815 0.011465020543287595 1.9947019126950612e-11 10.700121995889125 -0.6265610398346104 GTYLATFHQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GTYLATFHQR 10 0 P55884;P55884-2;C9JQN7 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 9853400.0 4862000.0 3178100.0 1813300.0 False True 4042968.4231204637 3160978.944496542 2192452.646248082 1.0 0.7818460630114988 0.5422878481340927 21.946983505066996 -6.969922627325214 0.26002676696575056 1.0672341817163304 0.2497921425768839 0.9999817723526385 0.0007980479617167835 0.07632781845853828 0.009119902301887712 0.0049999721392535185 0.022601786712224254 1.0717102210880289e-07 6.969922627325214 -0.8174420391394466 GTYLATFHQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GTYLATFHQR 10 0 P55884;P55884-2;C9JQN7 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 13673300.0 3729600.0 6021200.0 3922500.0 False True 4828040.721406991 5686114.926939813 3208645.248248776 1.0 1.1777272096584062 0.6645853739430994 22.203006413669836 -6.813167481043822 1.4011328133037126 1.0965037718575392 0.6549389038959077 0.8679474719181023 0.07731522111575075 0.20251260652131706 0.782939978543265 0.043380828733192066 0.10021469259957091 1.5375615817005873e-07 6.813167481043822 -0.4415648679616315 GVAINFVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVAINFVK 8 0 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 20129800.0 5817000.0 4898800.0 9414000.0 False True 7626143.331908141 4167918.1353728436 8439929.585464485 1.0 0.5465302649025856 1.1067100653814654 22.86252221582091 -6.691367991798405 1.861752442334666 0.716060888400746 1.1047944854192664 0.37670883271191813 0.19173402917323984 0.4137561171478164 2.781628891156993 0.08235834137345281 0.21408217508040633 2.0353167569566642e-07 6.691367991798405 0.3887335970185204 GVAINFVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVAINFVK 8 0 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 13370400.0 3510300.0 2705600.0 7154500.0 False True 3398867.4479410746 3785960.1895176102 5280521.819600703 1.0 1.1138887430902973 1.5536121665466756 21.696622668795126 -6.945688577627031 0.6043356776146038 0.9950905806874183 1.6950878149746462 0.998817952324085 0.008206840104442921 0.08526476126936602 0.04349467942553901 0.008387426695278056 0.037006287874699145 1.1332126721490657e-07 6.945688577627031 0.6999972342872279 GVAINFVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVAINFVK 8 0 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 20596200.0 5817000.0 8252900.0 6526300.0 False True 7967702.09851422 7888259.5893092705 4984922.353367599 1.0 0.9900294327997324 0.6256411562245988 22.9257322773438 -6.912761598992529 0.8767044583540836 1.0103208706383493 0.5756564666197166 0.9919229307579192 0.0156532692303413 0.10262043970522773 0.129066405511486 0.012993149152338533 0.03659248664058072 1.222470537285411e-07 6.912761598992529 -0.4346644040186327 GVAINFVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVAINFVK 8 0 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 9314500.0 3510300.0 3648900.0 2155300.0 False True 2918969.982657296 3629242.651450059 2605963.2650187486 1.0 1.2433298982218937 0.892768093026568 21.477027944229402 -6.720010505406035 1.7591748640497376 1.148036625472052 0.893310605673774 0.5126034859953281 0.10239400686513198 0.35530237255741026 2.1488726025748 0.04621498195283446 0.11601996984670855 1.9054146262046547e-07 6.720010505406035 -0.254726019798278 GVAINFVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVAINFVK 8 0 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 5848100.0 2194200.0 2027900.0 1626000.0 False True 2840435.1541482247 1915045.5823326334 1330084.6841688992 1.0 0.674208520316285 0.46826792797097255 21.437680536603494 -8.7874782308395 0.12590926014170972 1.5262317147872726 4.4208533986987456e-12 0.9999316625440832 0.0018096348072785976 0.3147984102950481 0.03634389638729561 0.2351321015014838 0.17624218411866918 1.631254674381012e-09 8.7874782308395 -1.5262317147828517 GVAINMVTEEDK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVAINMVTEEDKR 13 1 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 35282700.0 8802200.0 16815500.0 9665000.0 True False 11539769.440626064 14306692.946305621 8664958.5132265 1.0 1.2397728585407026 0.7508779579877293 23.460111064088498 -6.773308918195636 1.5614972944015226 1.136939731599867 0.7477566280761011 0.7431976340940221 0.10114999369120599 0.26109013423266375 1.2567533980466452 0.051042914492332385 0.12115274335904619 1.685353789192452e-07 6.773308918195636 -0.38918310352376595 GVAINMVTEEDK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVAINMVTEEDKR 13 1 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 31257800.0 8892800.0 10859900.0 11505100.0 True False 8610502.931672614 15196314.70363035 8491569.164398344 1.0 1.7648579675564229 0.9861873611543889 23.03766607591719 -10.25112361781809 4.884518920460638 0.9999174466082628 1.3755226643558534 0.23670020217706444 0.31789094389963873 0.00028584585319477623 4.382510097984235e-05 0.30786397823114553 0.10259886096923403 5.6088830175667513e-11 10.25112361781809 0.3756052177475906 GVAINMVTEEDK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVAINMVTEEDKR 13 1 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 121498600.0 18289100.0 26267500.0 76942000.0 True False 27745901.81230907 21579859.396085758 61734379.97512346 1.0 0.77776745344468 2.2249909335344036 24.725771359217244 -6.867715362505709 1.1460479492009117 0.8758816259967533 2.3061702921539107 0.962352799772545 0.12346982716211075 0.13906776108717778 0.34279997270846974 0.08371871886460071 0.19746791436409544 1.3560778973973972e-07 6.867715362505709 1.4302886661571574 up GVAINMVTEEDK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GVAINMVTEEDKR 13 1 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 28799840.0 9596860.0 11615670.0 7587310.0 True False 13145078.487389917 11102451.291515958 5795343.643554478 1.0 0.8446089768247902 0.4408755451033598 23.648019420319656 -6.954630953738377 0.5054544975214691 1.0077170630180907 0.26019172008707225 0.9995163716618211 0.005182248390326197 0.08167777538416705 0.028666142007596446 0.006016864909122457 0.033312123361403725 1.1101177486969954e-07 6.954630953738377 -0.7475253429310185 down GVAINMVTEEDK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVAINMVTEEDKR 13 1 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 33675300.0 8892800.0 17880200.0 6902300.0 True False 7394757.217837447 17783875.81365816 8345539.017370614 1.0 2.40493031613808 1.1285751203893097 22.818071351351467 -6.623242481319205 2.1046435935223706 1.9300726031863031 1.1335121603272742 0.09385602260268455 0.6036681193152427 0.5767753283334901 4.859113321211965 0.2353022835054427 0.6692299029402063 2.3809897109666874e-07 6.623242481319205 -0.7965604428590289 GVAINMVTEEDK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVAINMVTEEDKR 13 1 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 96570800.0 18289100.0 20717700.0 57564000.0 True False 23675600.482058305 19564741.78267806 47087942.65651813 1.0 0.8263672888678997 1.9888806069439304 24.496897681309694 -6.868877758345978 1.1399354471600212 0.9024240049571204 2.0555499088874 0.9635544521679518 0.09774808357900619 0.13793972487338158 0.3356976860710619 0.06658897935663015 0.15736159221392546 1.35245318707122e-07 6.868877758345978 1.1531259039302797 GVAINMVTEEDKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVAINMVTEEDKR 13 1 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 44431000.0 7771600.0 15895100.0 20764300.0 False True 10188642.860281449 13523613.038614517 18615809.42123011 1.0 1.327322316040131 1.8271137458159832 23.280458559764735 -6.964960301473435 0.3587375688609728 0.9563070818167073 2.215222579074174 0.9999123190764792 0.003184682013126948 0.07797448841356468 0.014907777370297026 0.0067229034539714305 0.04272093500096362 1.0840259994803266e-07 6.964960301473435 1.2589154972574668 GVAINMVTEEDKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVAINMVTEEDKR 13 1 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 9329400.0 3580200.0 2913500.0 2835700.0 False True 3466548.5107024 4076875.743701786 2092945.100823498 1.0 1.1760619333942972 0.6037547417443816 21.725068518992686 -6.824121914565315 1.3540556218925928 1.0945194390005908 0.5901318211166028 0.8935831376449439 0.07807584298303286 0.18817686671582676 0.6767991790898108 0.04529899009977234 0.10430430041861057 1.4992639050681377e-07 6.824121914565315 -0.504387617883988 GVAINMVTEEDKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVAINMVTEEDKR 13 1 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 52546700.0 3513200.0 39171300.0 9862200.0 False True 5329781.249323602 32180875.468236223 7912931.847244187 1.0 6.037935510452755 1.4846635306558615 22.345644890865408 -6.621989515479562 2.109431218809486 4.3381555838001455 1.5022379497958631 0.089487895772423 2.165394384996047 0.5801223462314282 4.9079166373525815 0.8426712808076517 2.400561310064504 2.3878689289562075e-07 6.621989515479562 -2.835917634004282 GVAINMVTEEDKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVAINMVTEEDKR 13 1 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 38625300.0 7771600.0 13790100.0 17063600.0 False True 10644970.539593086 13180807.784237523 13033529.115873216 1.0 1.2382192825440521 1.2243837657789738 23.343668621287627 -10.032079645486059 4.503602350507789 0.9999901052813536 1.2313015241731633 0.9973237193357152 0.005648326135079807 2952116.5443210537 0.08115403606970065 309.71236386730425 0.0020670756968681476 9.287960387820727e-11 10.032079645486059 0.23131141889180973 GVAINMVTEEDKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVAINMVTEEDKR 13 1 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 9954200.0 3580200.0 3391260.0 2982740.0 False True 2977094.9297523433 3372990.609267592 3606417.14336845 1.0 1.132980536011387 1.2113880237162804 21.505473794426962 -13.99999999479198 0.05652644503330613 0.11929724665472133 1.5961540924714037 0.9999625703937023 0.0005337752228247503 12.499656564169072 0.05944250665020978 1.6073227245001334 0.3632016305066661 1.0000000119919109e-14 13.99999999479198 1.4768568458166824 GVCLIDEFDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVCLIDEFDK 10 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 7794600.0 1223100.0 3613100.0 2958400.0 False True 1603495.9445172485 3074039.563753493 2652293.146976642 1.0 1.917085960999402 1.6540691331621336 20.6127892743153 -10.059856256793024 5.262510317539639 0.999991135119175 1.7855775470820936 0.9224481478157525 0.10737617033242854 1.1168054075459034e-05 1.995262473064491e-06 0.10396770295359556 0.03465550995575058 8.712519100376858e-11 10.059856256793024 0.7855864119629186 GVCLIDEFDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVCLIDEFDK 10 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 8414300.0 1223100.0 4155100.0 3036100.0 False True 1675313.1230346793 3971513.942921755 2319035.7104422715 1.0 2.3706099405033694 1.3842401629622207 20.675999335838192 -10.122664200420399 5.463412572525538 0.9999858764084647 1.877425051733052 0.5133974245542836 0.4026837754473009 6.927872472528153e-05 1.1123758026957439e-05 0.3899031512128053 0.129965629674479 7.53938288863683e-11 10.122664200420399 0.8774391753245873 GVCLIDEFDK(ub)MNDQDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVCLIDEFDKMNDQDR 16 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 36258100.0 7571100.0 16194000.0 12493000.0 True False 9925785.418636687 13777918.323717609 11200344.201318014 1.0 1.388093510247375 1.1284088592413264 23.242749835281494 -10.354669287153595 5.012318754637793 0.9998495337533951 1.2582511847443987 0.5687152764105929 0.1060158148330905 0.00017836178078822003 2.29637886326105e-05 0.10270886518453143 0.0342164571069069 4.4190682886724993e-11 10.354669287153595 0.25840165099100354 GVCLIDEFDK(ub)MNDQDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVCLIDEFDKMNDQDR 16 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 19622500.0 8770400.0 5875700.0 4976400.0 True False 8491988.452674242 8221897.651370723 3672931.5512000704 1.0 0.9681946339413046 0.43251725690270043 23.017670978805697 -6.919073958427026 0.8315688147643021 1.0122186492663459 0.3479488170465068 0.9939196924491185 0.020300460232739008 0.09871988095461383 0.108461374723472 0.01740565536477533 0.05168526208894911 1.2048307455599482e-07 6.919073958427026 -0.664269832219839 down GVCLIDEFDK(ub)MNDQDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVCLIDEFDKMNDQDR 16 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 122166000.0 42892000.0 51069000.0 28205000.0 True False 65070299.8252271 41955337.946081765 22630269.387309335 1.0 0.6447693964645926 0.3477818520598826 25.955495865482018 -7.561978872474545 0.231109111543586 1.1600622768826512 5.381574969211843e-12 0.999887157083974 0.0028322393228874397 0.1299522610353409 0.024552829435406563 0.032772955032571965 0.07033422987621214 2.7417075470672175e-08 7.561978872474545 -1.1600622768772697 down GVCLIDEFDK(ub)MNDQDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVCLIDEFDKMNDQDR 16 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 31855100.0 7571100.0 13251000.0 11033000.0 True False 10370340.27128432 12665527.00480281 8427232.631767573 1.0 1.2213222202432363 0.8126283623597915 23.305959896804385 -6.759643592714364 1.6139564073999062 1.128613114885457 0.8111684120909696 0.689471266861839 0.0930834137938897 0.28350829906473946 1.4554532714499953 0.04550847714093701 0.10939625319791037 1.7392275544277049e-07 6.759643592714364 -0.31744470279448744 GVCLIDEFDK(ub)MNDQDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVCLIDEFDKMNDQDR 16 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 22557300.0 8770400.0 6126800.0 7660100.0 True False 7292976.194598052 6093793.712325416 9261791.493699295 1.0 0.8355702184848928 1.269960472455615 22.798076254239973 -6.80411606162482 1.438841691695091 0.9097459220394418 1.2765996133709652 0.8439935166027609 0.07073042761222553 0.21492419805309615 0.8779285345025435 0.03866330183777106 0.08970921727162835 1.569943193873826e-07 6.80411606162482 0.36685369133152335 GVCLIDEFDK(ub)MNDQDR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GVCLIDEFDKMNDQDR 16 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 160892300.0 59487000.0 54867000.0 46538300.0 True False 77007094.16407594 51813603.21803082 38068806.92328257 1.0 0.6728419476215223 0.4943545440394217 26.198488022277363 -12.105957231158593 0.08996038530657749 2.2570018139083103 1.2396955840332226e-20 0.9998944195618459 0.002151441546842999 5.935650394365925 0.06764361431838034 1.7932763983675934 0.3701971204746218 7.835067978520606e-13 12.105957231158593 -2.2570018139083103 GVCSCVEAGK(ub)ACDPAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVCSCVEAGKACDPAAR 17 1 P26358;P26358-2;P26358-3;K7ENW7 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 4419900.0 1306200.0 2107200.0 1006500.0 True False 1712440.8492587944 1792813.9738012676 902357.035029744 1.0 1.0469348325679462 0.526942016958026 20.70762272501496 -6.884858710376485 1.052292390378723 1.031479323397117 0.48647134667611913 0.9773993682025407 0.035305782720729054 0.12341489235648037 0.24699663753989667 0.02572094764355228 0.06304535068907405 1.3035908084712721e-07 6.884858710376485 -0.5450079767209978 GVCTEAGMYALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVCTEAGMYALR 12 0 P62195;P62195-2 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 0 13073600.0 3003100.0 5733600.0 4336900.0 False True 3937093.182061769 4878169.229397751 3888159.190482356 1.0 1.2390281367034248 0.9875710354526618 21.908699427543134 -6.657687797377729 1.981519241469419 1.15415621820984 0.9886324182840684 0.22564835672410022 0.1018302250549626 0.48994977756023467 3.6957840861540223 0.04155854613219127 0.11282716768890565 2.1994404231733215e-07 6.657687797377729 -0.1655237999257715 GVCTEAGMYALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVCTEAGMYALR 12 0 P62195;P62195-2 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 0 12826400.0 3003100.0 3798500.0 6024800.0 False True 4113427.22572598 3630669.710040261 4601866.324650901 1.0 0.8826386151512582 1.118742613427108 21.971909489066025 -6.771557888196977 1.5685903178993967 0.9328188438767258 1.1201464827132221 0.7364574820180501 0.04948294477236183 0.2639130683179032 1.2817471801741482 0.02486275971578008 0.0590970913049542 1.6921626768108994e-07 6.771557888196977 0.1873276388364964 GVCTEAGMYALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVCTEAGMYALR 12 0 P62195;P62195-2 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 0 3312500.0 2019000.0 0.0 1293500.0 False True 1678887.9568655342 0.0 1563964.8695317374 1.0 0.0 0.9315480899938332 20.679074522369742 -10.034157813755797 13.033472514026265 1.000010053546916 0.46577404499691677 0.30483559216829126 0.38030291526915455 0.0 0.0 0.36822671431787674 0.12274223810595888 9.243622185275741e-11 10.034157813755797 -0.5342360085499993 GVDDLDFFIGDEAIEK(ub)PTYATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVDDLDFFIGDEAIEKPTYATK 22 1 P61158;B4DXW1;F8WDR7 P61158 ACTR3 Actin-related protein 3 1 22419300.0 6129500.0 8571100.0 7718700.0 True False 7934758.580508418 8094110.750397564 6313975.800550109 1.0 1.0200828000338398 0.7957363461643646 22.919754898244523 -6.885053157695497 1.0511690524047186 1.0135222235207042 0.7782092918861486 0.9775398545079372 0.015190005351837071 0.12325012462314247 0.24601159912455428 0.011075634455132223 0.02716397995123952 1.3030072804473347e-07 6.885053157695497 -0.23531293163455558 GVDDLDFFIGDEAIEKPTYATK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVDDLDFFIGDEAIEKPTYATK 22 1 P61158;B4DXW1;F8WDR7 P61158 ACTR3 Actin-related protein 3 0 9764900.0 3305300.0 2370800.0 4088800.0 False True 3200375.0607297462 3317472.803558675 3017820.6186293047 1.0 1.0365887561947906 0.9429584224860146 21.609809557732813 -6.800766143454781 1.4532351560520644 1.0201681313708673 0.9416481090664668 0.8342604876969648 0.015684859853934145 0.21967384095069398 0.9158970890475345 0.008491353736107703 0.019734616042586802 1.5820997304542518e-07 6.800766143454781 -0.07852002230440047 GVDEVTIVNILTNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVDEVTIVNILTNR 14 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9 P07355 ANXA2 Annexin A2;Annexin 0 11432500.0 2150900.0 5499100.0 3782500.0 False True 2819850.7293452267 4678655.715323917 3391123.18430204 1.0 1.659185596824236 1.2025896083830876 21.42718736395775 -10.275499473074865 4.46451928345547 0.9997490430754596 1.4308876025933626 0.542839390242496 0.18640453172597554 0.0004661226033555415 7.564221920351751e-05 0.1805893503822282 0.06016180391764459 5.3027423600523175e-11 10.275499473074865 0.4311385595179029 GVDEVTIVNILTNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVDEVTIVNILTNR 14 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9 P07355 ANXA2 Annexin A2;Annexin 0 23232900.0 10316000.0 4813600.0 8103300.0 False True 9988524.22669292 6735695.582592378 5980802.6362108225 1.0 0.6743434194805458 0.5987673955105371 23.251840109393207 -13.999999999999998 0.20521760675101058 2.847353838425975 0.5521332777868967 0.9994878904685673 0.0039395200913625965 12.638956514704583 0.14361580793429768 9.393289092202313 0.04631593718023316 1.0000000000000041e-14 13.999999999999998 -2.2952205606390783 GVDEVTIVNILTNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVDEVTIVNILTNR 14 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9 P07355 ANXA2 Annexin A2;Annexin 0 27644100.0 2150900.0 9210200.0 16283000.0 False True 2946145.855886917 8803262.90994151 12437290.758911587 1.0 2.9880607887593356 4.221546171605759 21.49039742548064 -8.431679723137139 0.24263247581736352 5.271532071235971e-16 5.262573909142781 0.9994210148534535 0.03193431861880919 0.1384719969267805 0.06232647513420516 0.5460947008043293 0.4826381655718681 3.7010101561007042e-09 8.431679723137139 5.26257390914278 GVDEVTIVNILTNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVDEVTIVNILTNR 14 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9 P07355 ANXA2 Annexin A2;Annexin 0 15707700.0 10316000.0 2545600.0 2846100.0 False True 8578211.076287694 2531886.3475379613 3441206.351120428 1.0 0.2951531881206239 0.40115664216199776 23.032245384827483 -10.54496770125578 6.671312387268294 1.0006004568227758 0.3481549151413108 0.9805516400182417 0.04327572889565554 0.0003868139153278835 2.6383555850375847e-05 0.041936560342743776 0.01396718144232175 2.8512303073475935e-11 10.54496770125578 -0.652445541681465 GVDFFK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVDFFKQR 8 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 85840000.0 23966300.0 33637400.0 28236300.0 True False 31420051.389979362 28618831.037558254 25314678.537715208 1.0 0.9108460925905905 0.8056854593747956 24.90518220448743 -6.968945363832085 0.2822863021702856 1.0225388780187636 0.6907783658572992 0.9999729218251847 0.0004132259579439302 0.07664682047003937 0.010251886551038081 0.0019172126607381141 0.009624854021663272 1.0741245334617966e-07 6.968945363832085 -0.3317605121614644 GVDFFK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVDFFKQR 8 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 120506700.0 31690700.0 38318300.0 50497700.0 True False 30684696.07511216 53618997.017294765 37270837.47147253 1.0 1.7474182206674755 1.2146392905518226 24.871015958193723 -10.44299579236967 4.90258830129781 0.9991058534053313 1.481028755609709 0.5208187136548972 0.21750608741508867 0.0021294579428274 0.00024193721936936028 0.2109690991332214 0.07019978785475148 3.6058213647838083e-11 10.44299579236967 0.4819229022043777 GVDFFK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVDFFKQR 8 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 110218100.0 53881000.0 48984900.0 7352200.0 True False 81741416.22873877 40243161.874229446 5899034.44741627 1.0 0.49232278728345175 0.0721670203377548 26.2845639035143 -8.02796599511732 0.45708334964074687 1.0412953801153872 1.0522418990846906e-18 0.9956524435357252 0.02501266031505303 0.10032991765547271 0.1105967105890396 0.04539594451532935 0.07927585138581361 9.376354200949763e-09 8.02796599511732 -1.0412953801153872 GVDFFK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVDFFKQR 8 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 85217100.0 23966300.0 22981000.0 38269800.0 True False 32827288.7749048 21965623.43199558 29231261.43127154 1.0 0.6691269444337254 0.890456157732335 24.968392266010323 -10.159016604158195 7.029597794695378 1.0000002698105661 0.7797915510830302 0.5689402631863861 0.0903572729588691 3.820296685679942e-07 4.5807480137483885e-08 0.0874881602442555 0.02916268444820148 6.93399295130149e-11 10.159016604158195 -0.2202087187275359 GVDFFK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVDFFKQR 8 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 107243000.0 31690700.0 46815800.0 28736500.0 True False 26352221.186051782 46563593.99319128 34745169.28743621 1.0 1.766970369003937 1.3184911071491314 24.651421233628 -10.23026892407979 4.3461933930325305 0.999755412472015 1.5427307380897053 0.6613203798639625 0.18309089200581086 19736823.941816453 46457614.97620894 28219.51887454546 0.0626768861812181 5.884791441154754e-11 10.23026892407979 0.5429753256176902 GVDFFK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVDFFKQR 8 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 113699700.0 53881000.0 54229000.0 5589700.0 True False 69750016.65329538 51211108.47887782 4572431.9551653685 1.0 0.7342092652598431 0.0655545643507648 26.05569022560675 -7.306171648714193 0.6767270589917153 0.9960128119712794 1.5149843938181673e-19 0.9944035334966891 0.02940956870913428 0.10077447707472835 0.08969229333928559 0.026572347149208864 0.06392191690914037 4.9411535632495734e-08 7.306171648714193 -0.9960128119712794 down GVDLSGNDFK(ub)GGYFPENVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVDLSGNDFKGGYFPENVK 19 1 Q13045;Q13045-2;J3KS54 Q13045 FLII Protein flightless-1 homolog 1 48249200.0 4193100.0 8859100.0 35197000.0 True False 6361239.256671634 7278124.388535763 28240297.52260691 1.0 1.144136243720515 4.439433321579382 22.60087641899929 -6.916069122262809 0.8533785647892209 0.9164913187003207 4.925575463374654 0.9930173868008874 0.13273673714057116 0.10054003359457092 0.11800956532052805 0.11204656033425996 0.323991211557739 1.213195742994548e-07 6.916069122262809 4.009084144674333 up GVDLSGNDFK(ub)GGYFPENVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVDLSGNDFKGGYFPENVK 19 1 Q13045;Q13045-2;J3KS54 Q13045 FLII Protein flightless-1 homolog 1 5208600.0 1468800.0 1245800.0 2494000.0 True False 2011855.052827518 1190756.4366903135 1904968.565542315 1.0 0.5918698939154641 0.9468716759018092 20.940094937042296 -10.179258365999976 7.641840053102233 1.0000001232928888 0.7693707849086366 0.360097506534074 0.1449288706075504 3.044340263995619e-07 3.283556003789028e-08 0.14032685083843704 0.046775591853974355 6.618226618419428e-11 10.179258365999976 -0.23062933838425215 GVDLSGNDFK(ub)GGYFPENVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVDLSGNDFKGGYFPENVK 19 1 Q13045;Q13045-2;J3KS54 Q13045 FLII Protein flightless-1 homolog 1 35444300.0 4193100.0 6955200.0 24296000.0 True False 5428050.608357913 6568137.005887833 19874377.298012044 1.0 1.2100360663134675 3.6614207810461843 22.37200274109174 -6.923798823359708 0.7960493241884253 0.9529529024040012 4.093458579886259 0.9951726897081948 0.08394062996319528 0.09598773743212274 0.09440858963928078 0.0738187237055424 0.22983242958876096 1.191793950521742e-07 6.923798823359708 3.140505677482258 up GVDLVLNSLAEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVDLVLNSLAEEK 13 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 12296900.0 2123400.0 4426500.0 5747000.0 False True 2783797.9630348533 3766083.4543618616 5152355.569116676 1.0 1.35285803940173 1.850836748044624 21.408623079251985 -6.966250664257226 0.33589550570880433 0.9433532804647038 2.2767884004248202 0.9999366533919755 0.0027779660061771046 0.07753907573644793 0.013377340655330723 0.0071214768693324965 0.043234559538052934 1.080809953906793e-07 6.966250664257226 1.3334351199601164 GVDLVLNSLAEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVDLVLNSLAEEK 13 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 8565600.0 2123400.0 3258200.0 3184000.0 False True 2908478.362727366 3114241.9505734323 2432004.776538382 1.0 1.0707461298261527 0.836177709865381 21.471833140774876 -6.825820315694765 1.3464394664360422 1.037924813953624 0.8303859768170261 0.8972610573587539 0.03148973093293428 0.18602659449219425 0.6610119299209369 0.018370079140995664 0.0422903984625839 1.493412163739042e-07 6.825820315694765 -0.20753883713659782 GVDYIHSKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVDYIHSKK 9 1 P19525-2;P19525 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 1 1984760.0 278710.0 923530.0 782520.0 True False 365391.5090314797 785742.9238917449 701552.3368618716 1.0 2.1504137465439856 1.920001750236157 18.479083583441877 -10.169287347912057 5.023140819923845 0.9999304596305898 2.035207748391614 0.9641761072689925 0.09406530360039922 7.326156721382788e-05 1.2115866062651907e-05 0.09108439660468616 0.030359446190923116 6.771932991312683e-11 10.169287347912057 1.035277288761024 GVEEEEEDGEMRE ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVEEEEEDGEMRE 13 1 P62306 P62306 SNRPF Small nuclear ribonucleoprotein F 0 19394640.0 693940.0 10979000.0 7721700.0 False True 909762.0601245185 9340975.995806811 6922732.555776626 1.0 10.26749345265983 7.609388057828127 19.795129745501292 -10.037012188372184 9.496144259930485 0.9999999958902005 8.938440755243978 0.9224341404402452 1.0851669833128141 1.3727154933196287e-07 1.3190006163860479e-08 1.0507084057277625 0.3502361378520558 9.183068240575459e-11 10.037012188372184 7.938440759353777 GVEEEEEDGEMRE ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVEEEEEDGEMRE 13 1 P62306 P62306 SNRPF Small nuclear ribonucleoprotein F 0 24615600.0 7240800.0 1789800.0 15585000.0 False True 7010944.76741353 2504476.4736837 11502820.960021926 1.0 0.35722382029371613 1.6406948480733126 22.741177438584486 -6.770578297955048 1.5725483277409074 0.6315816138164002 1.6480153207401433 0.7326289928291057 0.2709366712569235 0.26551152138931244 1.295924862931747 0.13580589675487012 0.3230625469573728 1.6959838096683446e-07 6.770578297955048 1.0164337069237432 GVEEEEEDGEMRE ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVEEEEEDGEMRE 13 1 P62306 P62306 SNRPF Small nuclear ribonucleoprotein F 0 18243740.0 693940.0 9020500.0 8529300.0 False True 950508.3710233704 8621944.483195523 6514855.006447499 1.0 9.070876960202524 6.8540743091333765 19.858339807024183 -9.252056864048132 8.857586722210266 0.9999208453880086 7.962475634674465 0.929341670902573 0.9050058937716834 0.0 0.0 0.8762681881675769 0.29208939605585893 5.596843148180143e-10 9.252056864048132 6.9625547892864565 GVEEEEEDGEMRE ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVEEEEEDGEMRE 13 1 P62306 P62306 SNRPF Small nuclear ribonucleoprotein F 0 7240800.0 7240800.0 0.0 0.0 False True 6021046.021828599 0.0 0.0 1.0 0.0 0.0 22.521582714018763 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 GVEGLIDIENPNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVEGLIDIENPNR 13 0 Q13442 Q13442 PDAP1 28 kDa heat- and acid-stable phosphoprotein 0 16199400.0 2199300.0 6281400.0 7718700.0 False True 2883303.598051493 5344239.604705431 6920042.966998589 1.0 1.853512619453953 2.4000396530129824 21.45929132302931 -8.514082208981007 0.1516802519785034 8.662233141267652e-17 3.3880005846372336 0.9998908060317987 0.006020274820451763 0.16256872143628892 0.03854001283854397 0.41504032196966706 0.35589578882145784 3.0613838797676325e-09 8.514082208981007 3.3880005846372336 GVEGLIDIENPNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVEGLIDIENPNR 13 0 Q13442 Q13442 PDAP1 28 kDa heat- and acid-stable phosphoprotein 0 18105800.0 5496000.0 1737800.0 10872000.0 False True 5321532.488358305 2431712.602507281 8024297.046991235 1.0 0.45695720317916644 1.507892146584777 22.343410340422093 -6.7662609160491485 1.5886961520242586 0.6870373411951258 1.512994289840554 0.7160629458790001 0.22866105486789637 0.2725285237085664 1.35688139028961 0.11348724254308462 0.27109169396842836 1.712927903083091e-07 6.7662609160491485 0.8259569486454281 GVEGLIDIENPNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVEGLIDIENPNR 13 0 Q13442 Q13442 PDAP1 28 kDa heat- and acid-stable phosphoprotein 0 13295000.0 2199300.0 5472600.0 5623100.0 False True 3012440.643847736 5230802.436531868 4295039.59137971 1.0 1.7364001668264104 1.4257673757494298 21.5225013845522 -10.111780733077328 4.532324389766147 0.9999529447831151 1.5810837712247257 0.8235009156464208 0.1268153060610657 14784945.838297669 32985759.350364417 4755.681488626771 0.04341224934237525 7.730707951435895e-11 10.111780733077328 0.5811308264416105 GVEGLIDIENPNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVEGLIDIENPNR 13 0 Q13442 Q13442 PDAP1 28 kDa heat- and acid-stable phosphoprotein 0 10443900.0 5496000.0 2275600.0 2672300.0 False True 4570167.514082703 2263340.8911287626 3231065.5746808327 1.0 0.4952424356775568 0.7069906222746746 22.12381561585637 -10.253686661533475 5.588183615693115 1.0000269345714607 0.6011165289761045 0.8255231404367633 0.08644583518713786 2.9010475180662927e-05 3.874470971189982e-06 0.08370646126585041 0.027900273335725315 5.5758789708735065e-11 10.253686661533475 -0.3989104055953563 GVEICIATPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVEICIATPGR 11 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 89996000.0 27755000.0 33761000.0 28480000.0 False True 36387073.77980233 28723990.399347294 25533162.79945066 1.0 0.7894009442246316 0.7017097047694877 25.116922699641904 -13.999999999999998 0.12016622533284285 2.003624909229524 0.5620621760662451 0.9996921249038798 0.002196357631851133 11.96309908218804 0.10670610866160878 2.866645295471419 0.12392257834035651 1.0000000000000041e-14 13.999999999999998 -1.4415627331632788 GVEICIATPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVEICIATPGR 11 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 47842300.0 27735000.0 10522000.0 9585300.0 False True 26854567.60637143 14723489.471505111 7074622.377163823 1.0 0.5482676052476028 0.26344205130621134 24.678664156616705 -8.463767630561689 0.22788371491647202 1.2635319004255714 7.140388483680245e-20 0.9995466829995983 0.006456801867076587 0.14558658494384913 0.057681990664060545 0.13517135070363825 0.11588902394783816 3.4374181790441776e-09 8.463767630561689 -1.2635319004255714 down GVEICIATPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVEICIATPGR 11 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 334404000.0 78954000.0 145230000.0 110220000.0 False True 119778990.31057025 119312571.81283085 88434968.68885784 1.0 0.996106007434776 0.7383178674286557 26.83579963523152 -6.9101863626140165 0.8944662422151523 1.0079346610083322 0.7048701073909991 0.9909916696182528 0.011622060955119652 0.10429486730925634 0.13810031021368943 0.00952391374115775 0.026324329044197528 1.2297409563278274e-07 6.9101863626140165 -0.3030645536173331 GVEICIATPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVEICIATPGR 11 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 111049000.0 27755000.0 35221000.0 48073000.0 False True 38016773.550672494 33664819.75972833 36719147.49451313 1.0 0.8855254303697431 0.9658670125062097 25.180132761164796 -10.241223029083292 4.801769372710253 1.000016886450246 0.9256962214378244 0.532810534957809 0.03279931356089956 5.930693354104891e-06 9.371706849657499e-07 0.03176501528951476 0.010585932932291956 5.7382170415494455e-11 10.241223029083292 -0.07432066501242152 GVEICIATPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVEICIATPGR 11 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 46962000.0 27735000.0 0.0 19227000.0 False True 23062881.36882889 0.0 23247276.80439634 1.0 0.0 1.007995333827484 24.45906943205098 -12.045127832556288 14.468752673975716 0.8782540982291732 0.5535979002223803 0.0 0.487244804139699 0.0 0.0 0.0 0.13987897530476523 9.013058033961291e-13 12.045127832556288 -0.3246561980067929 GVEICIATPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVEICIATPGR 11 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 274025000.0 78954000.0 118610000.0 76461000.0 False True 102207509.41601454 112009249.23343034 62545882.55611202 1.0 1.095900388077356 0.6119499723012713 26.60692595732397 -6.85521695561012 1.2096203354676558 1.051505079227466 0.5905624751912428 0.947562927764128 0.04791144829700224 0.15180989566994202 0.4248274320694468 0.030946772822791742 0.07189531396620086 1.3956709672268756e-07 6.85521695561012 -0.4609426040362232 GVEITGFPEAQALGLEVFHAGTALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVEITGFPEAQALGLEVFHAGTALK 25 0 P22102;P22102-2 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 83822000.0 20284000.0 49343000.0 14195000.0 False True 30772310.95903445 40537356.13138131 11389352.02811047 1.0 1.317332201190432 0.370116889929798 24.87512945640252 -6.816352178434846 1.3875068807768254 1.1716942464419986 0.35099831094836104 0.8758147173864892 0.13872330631135776 0.1982563514485426 0.7509264911363719 0.0785852552020265 0.18133268919201004 1.5263278252487648e-07 6.816352178434846 -0.8206959354936376 down GVEITGFPEAQALGLEVFHAGTALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVEITGFPEAQALGLEVFHAGTALK 25 0 P22102;P22102-2 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 32537600.0 20284000.0 5736200.0 6517400.0 False True 26258037.857416194 5416975.427474951 5331300.074171206 1.0 0.20629779943534535 0.20303497554237318 24.646255778494968 GVEKPPHLAALILAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVEKPPHLAALILAR 15 1 Q8NFW8;F5H296;Q8NFW8-2 Q8NFW8 CMAS N-acylneuraminate cytidylyltransferase 0 7215400.0 1348100.0 3683200.0 2184100.0 False True 1846529.0010326633 3520464.045286373 1668260.5629514721 1.0 1.9065306005578946 0.9034575476575265 20.816384490582806 -6.668681401268698 1.9422086489131642 1.5792899150584392 0.9075471403169911 0.2731872790288713 0.38519171484259174 0.46412838132902573 3.3741006995335385 0.15974251786058677 0.42750201728216375 2.1444632039029434e-07 6.668681401268698 -0.6717427747414481 GVEVTVGHEQEEGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVEVTVGHEQEEGGK 15 0 A0A096LPI6;P0DPI2;A0A0B4J2D5;A0A096LNH5;H7C1F6;H7C2G3;P0DPI2-2;A0A0B4J2D5-2 A0A096LPI6 C21orf33 0 3678140.0 996740.0 1209700.0 1471700.0 False True 1306735.7924438901 1029217.4753736671 1319422.601543241 1.0 0.7876247680097587 1.0097087790605503 20.317536042926804 -11.071280570369076 10.67880767781551 1.5847138395169162 0.89866677353499 0.21727787353243344 0.09066541785084337 0.042764942507925396 0.0002854545018758468 0.0029744500208804306 0.02926213778443775 8.486320500734443e-12 11.071280570369076 -0.6860470659819262 GVEVTVGHEQEEGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVEVTVGHEQEEGGK 15 0 A0A096LPI6;P0DPI2;A0A0B4J2D5;A0A096LNH5;H7C1F6;H7C2G3;P0DPI2-2;A0A0B4J2D5-2 A0A096LPI6 C21orf33 0 3615340.0 996740.0 1334500.0 1284100.0 False True 1365261.7138856887 1275537.377398637 980822.0268696424 1.0 0.934280485877183 0.718413192792254 20.380746104449695 -6.949397287658891 0.5654273172467034 1.002747107165594 0.6395334554830422 0.9991530897798407 0.0035003956180328084 0.08372879012805493 0.036971802155358266 0.003728094660193861 0.017966324352315464 1.1235766685239178e-07 6.949397287658891 -0.3632136516825518 GVEVTVGHEQEEGGKWPYAGTAEAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVEVTVGHEQEEGGKWPYAGTAEAIK 26 1 A0A096LPI6;P0DPI2;A0A0B4J2D5;A0A096LNH5;H7C1F6;H7C2G3;P0DPI2-2;A0A0B4J2D5-2 A0A096LPI6 C21orf33 0 8856100.0 1770300.0 3480500.0 3605300.0 False True 2320880.4436095846 2961222.9668827406 3232258.1404796117 1.0 1.275905001929894 1.3926861891483704 21.14624077582644 -12.907835401737536 0.129012737323311 5.046507095352804e-19 1.567946670923372 0.9996762480255956 0.0029624217028134995 8.084414939540888 0.10127612292278983 2.2127214614820048 0.1452994441196911 1.236415948160766e-13 12.907835401737536 1.567946670923372 GVEVTVGHEQEEGGKWPYAGTAEAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVEVTVGHEQEEGGKWPYAGTAEAIK 26 1 A0A096LPI6;P0DPI2;A0A0B4J2D5;A0A096LNH5;H7C1F6;H7C2G3;P0DPI2-2;A0A0B4J2D5-2 A0A096LPI6 C21orf33 0 10671400.0 1770300.0 3638000.0 5263100.0 False True 2424827.750558655 3477261.130742786 4020064.1769469767 1.0 1.4340239754933775 1.657876183584915 21.20945083734933 -10.77340497418851 0.12566955855086928 1.90082661625386e-18 2.0691311066136264 0.9997940420853937 0.00391942050544375 2.8537466810557914 0.07158554925316267 1.1120847963728058 0.2670486797402753 1.6849810687535913e-11 10.77340497418851 2.0691311066136264 GVFMMCIPPPNVTGSLHLGHALTNAIQDSLTR ddPTM_RPMI8226_Bortezomib_8h_R1 2 GVFMMCIPPPNVTGSLHLGHALTNAIQDSLTR 32 0 P26640;A0A140T936;A0A140T954;P26640-2 P26640 VARS Valine--tRNA ligase 0 1132011000.0 389051000.0 287929000.0 455031000.0 False True 590218810.4379474 236545820.35045496 365093923.4028275 1.0 0.4007764852071318 0.6185738525207706 29.136674659694464 -10.144605347742472 5.272860452495314 1.0000151393508685 0.5096751688636788 0.871096422121331 0.08891540287430756 1.5825029092159822e-05 2.5671834151165075e-06 0.08609462380626356 0.028697322879317724 7.167944801181924e-11 10.144605347742472 -0.4903399704871897 GVFMMCIPPPNVTGSLHLGHALTNAIQDSLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GVFMMCIPPPNVTGSLHLGHALTNAIQDSLTR 32 0 P26640;A0A140T936;A0A140T954;P26640-2 P26640 VARS Valine--tRNA ligase 0 801622000.0 389051000.0 233906000.0 178665000.0 False True 503634188.84172934 220888925.48010096 146149803.25771 1.0 0.4385900130968211 0.2901903931379818 28.907800981786913 -13.99999999999996 0.18677143033151988 3.976695711280311 0.18019813003188961 0.9994915123954085 0.0068932713370471995 12.299913731130516 0.13704283257887198 13.310857243723506 0.10473899142407013 1.000000000000094e-14 13.99999999999996 -3.7964975812484214 GVFTK(ub)ELPSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVFTKELPSGK 11 1 P30041 P30041 PRDX6 Peroxiredoxin-6 1 5657700.0 2402100.0 1472500.0 1783100.0 True False 2325846.6503430614 2060476.9289860558 1316052.6181466228 1.0 0.8859040335622025 0.5658380865103491 21.149324548300907 -6.952949310926174 0.525469649978005 1.0052178229058373 0.4321067391069101 0.9994128655786634 0.004453003007353322 0.08232264265227884 0.03122517676420262 0.005001865627057913 0.02645307473328173 1.1144245970776033e-07 6.952949310926174 -0.5731110837989272 GVFTK(ub)ELPSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVFTKELPSGK 11 1 P30041 P30041 PRDX6 Peroxiredoxin-6 1 6483200.0 2402100.0 4081100.0 0.0 True False 1997452.5810731521 4059114.3042650796 0.0 1.0 2.032145515106185 0.0 20.929729823735183 -6.77420982142562 1.5949295471271843 1.592759972138861 1.0823330630169144e-12 0.7250508688185476 0.43503426483426094 0.26464473295458263 1.335051917505819 0.21621991231878343 0.5051799544373259 1.681861304263062e-07 6.77420982142562 -1.5927599721377788 GVFVQSVLPYFVATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVFVQSVLPYFVATK 15 0 A0A1B0GV93;Q53GQ0 A0A1B0GV93 HSD17B12 Very-long-chain 3-oxoacyl-CoA reductase 0 4414850.0 1329500.0 2565300.0 520050.0 False True 1742987.3748963126 2182567.2394610806 466240.214671851 1.0 1.2521991099281014 0.2674948891695712 20.733130688850625 -6.838749432738954 1.288125938459018 1.1341923825708484 0.23588520721481027 0.922303626380409 0.11641333697836118 0.17025430055910865 0.5492843445262608 0.070879077101648 0.16324688349969552 1.4496079671764856e-07 6.838749432738954 -0.8983071753560381 down GVFVVAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVFVVAAK 8 0 P42765 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 27587400.0 10104500.0 9542200.0 7940700.0 False True 13247097.352117194 8118540.955204274 7119072.536572962 1.0 0.6128543287187923 0.5374062217060078 23.659172941286545 -13.999999999999957 0.22992801178849115 3.4431222249821416 0.5006975717605341 0.9995096951606522 0.004487021810300479 13.289021189675294 0.151827324049229 14.821414047261396 0.03918181442969252 1.0000000000000981e-14 13.999999999999957 -2.9424246532216074 GVFVVAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVFVVAAK 8 0 P42765 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 13305300.0 4813200.0 1536700.0 6955400.0 False True 4660407.600612479 2150312.3237846326 5133572.082472668 1.0 0.4614000551157874 1.1015285619648385 22.152024708252295 -6.683639160700669 1.8895052043755511 0.6603327453514568 1.0991343416423283 0.3406606376721736 0.22809307554346953 0.43046067156909984 2.974526762038876 0.09676596595933054 0.2539790062433512 2.0718620677812205e-07 6.683639160700669 0.43880159629087145 GVFVVAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVFVVAAK 8 0 P42765 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 16998400.0 2371500.0 11821000.0 2805900.0 False True 3597738.8798733074 9711450.192105455 2251312.635130341 1.0 2.6993204666502755 0.6257576523201206 21.77865905041541 -6.688882088519722 1.870188984633667 2.066464578943512 0.6329790856777724 0.36529186724148077 0.7188545518378512 0.41907362627788397 2.8409114231934103 0.307581683016947 0.8021533704980406 2.0470003243651428e-07 6.688882088519722 -1.4334854932657397 GVFVVAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVFVVAAK 8 0 P42765 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 23092300.0 10104500.0 5886300.0 7101500.0 False True 13840406.713845082 5626223.802608922 5424271.959983458 1.0 0.4065071149232051 0.39191564757684133 23.722383002809437 GVFVVAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVFVVAAK 8 0 P42765 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 9107300.0 4813200.0 2825600.0 1468500.0 False True 4002389.0609139116 2810377.93196231 1775556.5604231595 1.0 0.7021750982201076 0.443624178809275 21.93242998368657 -7.129758250322839 0.1929405238774653 1.1791107508154097 5.909126456888153e-14 0.9999933920030836 0.0005843414712935804 0.08028302575404328 0.007498133998646625 0.011571308490511576 0.03174916977878182 7.417230059277073e-08 7.129758250322839 -1.1791107508153507 down GVGAAATAVTQALNELLQHVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVGAAATAVTQALNELLQHVK 21 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 4076100000.0 1830800000.0 1118500000.0 1126800000.0 False True 2777457449.408416 918894936.1196121 904087486.1060156 1.0 0.33084032891856974 0.32550903211805515 31.37111766371127 GVGAAATAVTQALNELLQHVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVGAAATAVTQALNELLQHVK 21 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 3496870000.0 1830800000.0 1021400000.0 644670000.0 False True 2370006690.4633007 964558192.117239 527346674.8727944 1.0 0.4069854300405719 0.22250851737878682 31.14224398580372 -13.999999999999709 0.16349808128627408 3.94313934222371 0.047980406091814504 0.9995276078594965 0.007209239089048695 12.034835260305718 0.1278897744206775 11.230679756125264 0.15979459686078146 1.0000000000006708e-14 13.999999999999709 -3.895158936131896 GVGGK(ub)LPNFGFVVFDDSEPVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVGGKLPNFGFVVFDDSEPVQR 22 1 Q9UN86-2;Q9UN86 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 44901200.0 9297200.0 12027000.0 23577000.0 True False 14104532.116364382 9880687.8826201 18916995.61583382 1.0 0.7005328359071417 1.3411997973251386 23.74965547302076 -6.779591241452147 1.5373393292055102 0.8303422565577722 1.346220350746113 0.7659655480891285 0.1266203504852753 0.2512190742503799 1.1726945561001425 0.0648710877556194 0.15312883153366547 1.661149648168365e-07 6.779591241452147 0.5158780941883409 GVGGK(ub)LPNFGFVVFDDSEPVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVGGKLPNFGFVVFDDSEPVQR 22 1 Q9UN86-2;Q9UN86 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 33716500.0 9297200.0 9239300.0 15180000.0 True False 12035408.675210504 8725124.833002556 12417395.759953195 1.0 0.7249545959310726 1.0317386052315345 23.52078179511321 -6.670298582722799 1.9356306289223366 0.8244976864994782 1.03052087198067 0.28075594452809505 0.1168227520084345 0.4603745473198461 3.3254719707209426 0.04857564784398744 0.1297637858124392 2.1364927198022336e-07 6.670298582722799 0.2060231854811918 GVGISVLEMSHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVGISVLEMSHR 12 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 23894900.0 8379800.0 5829400.0 9685700.0 False True 10985998.950098641 4959676.242823227 8683516.675794909 1.0 0.451454279701956 0.7904166671813618 23.389162723306235 -10.379397382142942 6.371986647354032 1.000042096069726 0.6209354734416692 0.6251150799643775 0.13838081522001705 8.276426677591227e-05 8.060723602569693e-06 0.13400147605007062 0.044662216065144304 4.174482241292413e-11 10.379397382142942 -0.37910662262805683 GVGISVLEMSHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVGISVLEMSHR 12 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 23340100.0 7293400.0 1665500.0 14381200.0 False True 7061875.009205317 2330542.8354677632 10614332.293247838 1.0 0.33001757074854016 1.5030473180864588 22.751619855842893 -6.751803678877177 1.6432563312222874 0.6068926509646064 1.5056889535044806 0.6566381311878848 0.2815596566656417 0.2969213757369177 1.5780418853596856 0.13532444644735767 0.32790024752083385 1.7709093100367133e-07 6.751803678877177 0.8987963025398742 GVGISVLEMSHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVGISVLEMSHR 12 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 21503300.0 3147700.0 14526600.0 3829000.0 False True 4775291.027694381 11934214.733156163 3072196.4716896825 1.0 2.499159666697482 0.6433527200483545 22.18715722947088 -6.69174707760138 1.8601490134400651 1.9383318144485169 0.6496178569334358 0.37864129886065967 0.6338153993987105 0.41292474195021117 2.771485497778812 0.2724418337657108 0.7079144939098513 2.0335409502661903e-07 6.69174707760138 -1.288713957515081 GVGISVLEMSHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVGISVLEMSHR 12 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 31016000.0 8379800.0 10136800.0 12499400.0 False True 11478038.515580095 9688922.658085052 9547299.153223585 1.0 0.8441270383379069 0.8317883879082861 23.452372784829127 -13.999999999999849 0.3595597637790104 3.033893564103153 0.8302933362432612 0.999772486886181 0.0011546812532026176 21.649508133790548 0.19375662365172536 33.78193884982651 0.0035656214610213857 1.0000000000003477e-14 13.999999999999849 -2.2036002278598916 GVGISVLEMSHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVGISVLEMSHR 12 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 13302300.0 7293400.0 1435400.0 4573500.0 False True 6064785.252403703 1427667.215295409 5529797.704525243 1.0 0.23540276462873452 0.9117878827339477 22.53202513127717 -10.78306197185324 9.816503707368787 1.003164091261555 0.5735953236817164 0.34636284484261426 0.2761330681616514 0.019165563114892464 0.00042354518349081526 0.26797808554786123 0.08912156452726944 1.6479272230050442e-11 10.78306197185324 -0.42956876757983853 GVGISVLEMSHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVGISVLEMSHR 12 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 17670000.0 3147700.0 10752100.0 3770200.0 False True 4074759.700443158 10153736.183144474 3084062.285518809 1.0 2.491861343882484 0.7568697327558718 21.95828355156333 -6.679147787033825 1.904973950425922 1.9446387591308205 0.7635246782365445 0.32021861501743265 0.6324040738461217 0.44040913719744623 3.089261766657497 0.2664565072286225 0.7035142435309406 2.093399966906316e-07 6.679147787033825 -1.1811140808942762 GVGTDEACLIEILASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVGTDEACLIEILASR 16 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 5402000.0 2879500.0 1373200.0 1149300.0 False True 2788091.848658611 1921525.9211433982 848263.8517390582 1.0 0.6891903227893552 0.3042453038794864 21.410846658300102 -7.1605357720675675 0.32918872553436923 1.054087538864473 8.800891756279642e-14 0.9999021412043511 0.0028151387180623093 0.0837024653267822 0.01670865584503971 0.008078089440446669 0.03807996943138934 6.909780124253718e-08 7.1605357720675675 -1.054087538864385 down GVGTDEACLIEILASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVGTDEACLIEILASR 16 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 3643900.0 0.0 1278500.0 2365400.0 False True 0.0 1222011.6425658742 1806741.236942176 0.0 GVGTQK(ub)IIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVGTQKIIGR 10 1 Q5TDH0;Q5TDH0-3 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 38268000.0 12596000.0 15518000.0 10154000.0 True False 16513477.979837533 13202774.888690243 9103361.484045714 1.0 0.7995150933564957 0.5512685755938663 23.97714066912837 -6.968248103427829 0.2970670075423997 1.044582839302474 0.2984545265945215 0.9999653096475419 0.0010810044572612774 0.07687537887797742 0.011054097811933663 0.0041796044661858885 0.02233432456249369 1.0758504270093034e-07 6.968248103427829 -0.7461283127079525 GVGTQK(ub)IIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVGTQKIIGR 10 1 Q5TDH0;Q5TDH0-3 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 64268000.0 16994000.0 21281000.0 25993000.0 True False 16454534.77204529 29778614.278948918 19184653.526714817 1.0 1.8097512139656473 1.1659189270612342 23.97198190115381 -10.514907082319635 5.557332160491655 0.9990172333374564 1.4878350705134313 0.4335848679473908 0.2628434304741681 0.003206422228766156 0.00027988444073900746 0.2549691798672828 0.08483235240720631 3.0555747861567366e-11 10.514907082319635 0.48881783717597493 GVGTQK(ub)IIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVGTQKIIGR 10 1 Q5TDH0;Q5TDH0-3 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 18252900.0 10072000.0 8180900.0 0.0 True False 15279960.36183174 6720954.477336561 0.0 1.0 0.4398541827454625 0.0 23.8651374650549 -8.12942869407927 0.5580698891269478 1.0219468373106306 1.220694632733248e-16 0.990639508254839 0.039593014030623846 0.11881504717186299 0.17019969610880764 0.05044639084289698 0.07426703253121436 7.422860621612229e-09 8.12942869407927 -1.0219468373106304 GVGTQK(ub)IIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVGTQKIIGR 10 1 Q5TDH0;Q5TDH0-3 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 35932200.0 12596000.0 14820000.0 8516200.0 True False 17253081.59410093 14165203.39681366 6504848.956644521 1.0 0.8210245410105139 0.37702534014958927 24.040350730651262 -6.955626715151975 0.4932199564398564 1.0094389817104208 0.16968015039717183 0.9995720582722838 0.005417596039557339 0.08130193107396134 0.027197434691037022 0.006437491641541095 0.03662037240248092 1.1075753582825131e-07 6.955626715151975 -0.8397588313132489 down GVGTQK(ub)IIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVGTQKIIGR 10 1 Q5TDH0;Q5TDH0-3 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 66438700.0 16994000.0 43689000.0 5755700.0 True False 14131263.961848862 43453638.685412504 6959190.2586500365 1.0 3.0750001417231507 0.492467643194426 23.752387176588087 -6.692793774596142 1.8562607117697056 2.2974543585184484 0.5010242737646984 0.3836286208799524 0.8770853169540297 0.41069581414083084 2.745763432550204 0.3776728513439656 0.9801196364928756 2.0286457964259182e-07 6.692793774596142 -1.79643008475375 GVGTQK(ub)IIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVGTQKIIGR 10 1 Q5TDH0;Q5TDH0-3 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 25660600.0 10072000.0 11654000.0 3934600.0 True False 13038402.54880181 11005444.65531067 3218543.17240526 1.0 0.844079220143578 0.2468510356509153 23.63626378714735 -6.945871974077857 0.6024707391455907 1.0066920632487448 0.05353631993920244 0.9988361418053735 0.011073494293858826 0.08518712101376548 0.043159077527711774 0.01133768151529663 0.050230243223926364 1.1327342334037226e-07 6.945871974077857 -0.9531557433095423 down GVHAVLK(ub)TGNWVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVHAVLKTGNWVR 13 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 4591400.0 1209700.0 2212300.0 1169400.0 True False 1005919.1487965496 2200381.9007928306 1413916.1333053065 1.0 2.1874341525611665 1.4055962002481728 19.940082921865443 -10.160481331850626 4.817819524355432 0.9999449630161159 1.7965151764002876 0.5805129472319716 0.31918400761215354 223510120.27215436 23.509019291406716 178196.21967399606 0.10926517557700079 6.910646341815079e-11 10.160481331850626 0.7965702133841717 GVIDLIFEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVIDLIFEK 9 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 9425300.0 0.0 6605800.0 2819500.0 False True 0.0 5620240.389206721 2527765.1865537586 0.0 GVIDLIFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVIDLIFEK 9 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 9121800.0 3873100.0 1847900.0 3400800.0 False True 3750150.5605277503 2585776.106671195 2510028.4581868863 1.0 0.6895126115436028 0.6693140495760938 21.838517087217056 -13.999999999999964 0.38839591046295835 5.859136153442531 0.6677943911330544 0.9998206997409144 0.0020266251807109325 25.13187536443985 0.20410925500862695 102.45598830833188 0.005340830379115033 1.0000000000000819e-14 13.999999999999964 -5.191341762309476 GVIDLIFEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVIDLIFEK 9 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 11308000.0 0.0 5006200.0 6301800.0 False True 0.0 4785009.530710424 4813444.629644968 0.0 GVIFYLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVIFYLR 7 0 O95831-3;O95831;E9PMA0;O95831-2;O95831-5 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 0 21909400.0 7185300.0 7654700.0 7069400.0 False True 9419997.882544182 6512648.597786905 6337926.302473196 1.0 0.6913641254479719 0.67281610691418 23.167295304868883 -13.999999999999998 0.40009513841719235 6.205781388181261 0.6717297575921377 0.9998379020955395 0.0019104609190027655 26.783191479318962 0.2084697858886255 121.04443026571603 0.004744613160658407 1.0000000000000041e-14 13.999999999999998 -5.534051630589124 GVIFYLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVIFYLR 7 0 O95831-3;O95831;E9PMA0;O95831-2;O95831-5 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 0 19218800.0 9986300.0 3087800.0 6144700.0 False True 9669290.372724252 4320774.642664276 4535218.732951344 1.0 0.44685540263146833 0.4690332545751834 23.20497858381243 -10.080981491603046 4.957546940474079 1.000014352605076 0.4579443286002575 0.9987460861289924 0.009054070162197768 4900166.832871927 9964301.260098223 525.0473369855305 0.003099449244209546 8.298861341500706e-11 10.080981491603046 -0.5420700240048184 GVIFYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVIFYLR 7 0 O95831-3;O95831;E9PMA0;O95831-2;O95831-5 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 0 61428000.0 11634000.0 17691000.0 32103000.0 False True 17649628.559327908 14533902.829586126 25757827.978755224 1.0 0.8234679149610145 1.4593977370216156 24.073134486163834 -6.832651459419043 1.3160654596997254 0.9058340202553642 1.4774504475567538 0.911067933830867 0.07993396556957501 0.1775606835584141 0.6005317421946423 0.04767534558468809 0.10971164764690963 1.4701056293004066e-07 6.832651459419043 0.5716164273013896 GVIFYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVIFYLR 7 0 O95831-3;O95831;E9PMA0;O95831-2;O95831-5 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 0 25984300.0 7185300.0 6687000.0 12112000.0 False True 9841899.58543135 6391546.229048105 9251395.054470137 1.0 0.6494220118349212 0.9400009595875862 23.230505366391775 -10.004437734295221 6.691631258182383 1.0000000447125126 0.7947114857112528 0.39957511268625046 0.11862835866481687 7.91249630586159e-08 1.1765768428569235e-08 0.11486144004766363 0.038287138124729225 9.898337682260942e-11 10.004437734295221 -0.20528855900125975 GVIFYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVIFYLR 7 0 O95831-3;O95831;E9PMA0;O95831-2;O95831-5 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 0 20514200.0 9986300.0 4050100.0 6477800.0 False True 8304050.918101172 4028281.3074180954 7832278.030036855 1.0 0.4850983390091271 0.9431876209915878 22.985383859246706 -10.338469156852051 8.440180319701799 1.0000007459492106 0.7141429800003578 0.341759605247012 0.1870141662491581 2.62492157778661e-06 2.0572134486161493e-07 0.18107616135040414 0.06035856261565452 4.587022212019712e-11 10.338469156852051 -0.2858577659488528 GVIFYLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVIFYLR 7 0 O95831-3;O95831;E9PMA0;O95831-2;O95831-5 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 0 63412000.0 11634000.0 26096000.0 25682000.0 False True 15060442.340424985 24643734.659772355 21008139.519572984 1.0 1.636322101484633 1.3949218120362437 23.844260808256283 -10.183720205456725 4.882646948605669 0.9999467019363689 1.5156219567617513 0.8588191611412084 0.09855125548936772 5.718605370060021e-05 9.56020588538058e-06 0.09543167093545708 0.03180728093752651 6.550580597952646e-11 10.183720205456725 0.5156752548253823 GVIINTASVAAFEGQVGQAAYSASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVIINTASVAAFEGQVGQAAYSASK 25 0 Q99714;Q99714-2 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 5611200.0 2112100.0 1788000.0 1711100.0 False True 2045052.5416050872 2501957.7242968227 1262911.578100322 1.0 1.2234197769477 0.6175448074840701 20.963706478769605 -6.806891781475941 1.4277059840459256 1.1222149064017353 0.6076958061307263 0.8515253021409787 0.09639719100707107 0.21106596873094832 0.8485214239397046 0.053101360936697165 0.12300804447786189 1.5599411642223656e-07 6.806891781475941 -0.514519100271009 GVILYGPPGTGK(ub)TLLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVILYGPPGTGKTLLAK 17 1 P62191;P62191-2;G3V4X1 P62191 PSMC1 26S protease regulatory subunit 4 1 7385200.0 1544600.0 2220600.0 3620000.0 True False 1284403.3373821194 2208637.1870454107 4376925.263011119 1.0 1.7195822548601218 3.407749836536708 20.292666888191228 -6.956809494040924 0.4782900688278686 0.9588198945255846 4.238692390073611 0.9996329286123011 0.01933389971834373 0.0808612607106035 0.025497418124743043 0.02372072227688971 0.1392684777253728 1.1045630370520696e-07 6.956809494040924 3.2798724955480267 GVK(ub)IWDANGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVKIWDANGSR 11 1 P04818;P04818-2 P04818 TYMS Thymidylate synthase 1 13398300.0 2748400.0 3045600.0 7604300.0 True False 3557857.979063433 2876109.682702435 6220395.426706988 1.0 0.8083823749084946 1.7483540555332788 21.762577492242276 -6.853604424303506 1.2175179998256616 0.8973358633777727 1.7886375977904603 0.9453946600576758 0.0947699952298774 0.15353619397510265 0.43615173126960727 0.06084635259374245 0.14117034132483805 1.400862712823727e-07 6.853604424303506 0.8913017344126876 GVLFASGQNLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVLFASGQNLAR 12 0 P28838-2;P28838;H0Y9Q1 P28838-2 LAP3 Cytosol aminopeptidase 0 20257900.0 5612000.0 6640600.0 8005300.0 False True 7357386.346685306 5649848.364856067 7176988.348259907 1.0 0.7679151397835008 0.9754806951918906 22.81076192061286 -10.304062524513038 7.102075723007502 1.000001464310104 0.8716979175501489 0.3375039537296246 0.08473828315465738 1.964693102004098e-06 1.9263718154071992e-07 0.0820484263372672 0.027349163287016386 4.9652083318734285e-11 10.304062524513038 -0.12830354675995514 GVLFASGQNLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVLFASGQNLAR 12 0 P28838-2;P28838;H0Y9Q1 P28838-2 LAP3 Cytosol aminopeptidase 0 13282400.0 4321600.0 2744100.0 6216700.0 False True 4184413.1735242424 3839833.4402924553 4588359.772997644 1.0 0.9176515991747605 1.0965360213540254 21.996593881225596 -6.781544931664044 1.52989542801645 0.9534649717570759 1.0980208758549446 0.7727826526924673 0.03484756754829625 0.24819379553282594 1.147521703700525 0.017938523753914956 0.04227226744895301 1.6536936864588985e-07 6.781544931664044 0.14455590409786867 GVLFASGQNLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVLFASGQNLAR 12 0 P28838-2;P28838;H0Y9Q1 P28838-2 LAP3 Cytosol aminopeptidase 0 17849900.0 5612000.0 5800800.0 6437100.0 False True 7686908.0585975135 5544501.475319609 4916789.556235933 1.0 0.7212915040811885 0.639631633259447 22.87397198213575 -13.999999999999998 0.17209936204706308 2.41342646038672 0.5691848833033625 0.9995098290713296 0.003415654385229429 12.112652853470335 0.13140855756733763 5.716771319702294 0.0653250479161638 1.0000000000000041e-14 13.999999999999998 -1.8442415770833578 GVLFGVPGAFTPGCSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVLFGVPGAFTPGCSK 16 0 P30044-2;P30044;P30044-3 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 147083000.0 35816000.0 39482000.0 71785000.0 False True 46955122.84263737 33591439.499630645 64357376.81034293 1.0 0.7153945611473963 1.3706145978155877 25.484779229896503 -6.788651342798192 1.5016072711247515 0.8406486705598096 1.3773347505406683 0.7969178325084031 0.12089020259503276 0.23739225765356323 1.057465566641277 0.06337147141772308 0.1485222167340876 1.6268542912014837e-07 6.788651342798192 0.5366860799808587 GVLFYGPPGCGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVLFYGPPGCGK 12 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 18018400.0 3536400.0 4815600.0 9666400.0 False True 4636254.646546313 4097131.2510617836 8666213.65465624 1.0 0.8837157497623349 1.86922727834028 22.144528377950753 -6.877466981645719 1.0937902946330007 0.9300764036848221 1.935774461695844 0.9715859013607697 0.07412404757873635 0.12989932925086498 0.28602444856930187 0.0523153381112981 0.12574068763324464 1.3259679240481276e-07 6.877466981645719 1.005698058011022 GVLFYGPPGCGK(ub)TLLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVLFYGPPGCGKTLLAK 17 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 28778500.0 2042500.0 11354000.0 15382000.0 True False 3098621.82675152 9327789.990793098 12341740.957829896 1.0 3.0103028095467868 3.9829774809172243 21.56319526036893 -8.998336886075927 0.2711513224895382 8.462970397926385e-14 4.5440694431927735 0.9989470523133993 0.04030546759156433 0.4659021337568064 0.09265935726192842 0.8279875627880947 0.37140606635571577 1.0038368030852225e-09 8.998336886075927 4.544069443192689 GVLK(ub)VGQEIEVRPGIVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVLKVGQEIEVRPGIVSK 18 2 P41091 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 9286100.0 1758800.0 2616200.0 4911100.0 True False 1702967.8567184443 3660862.3033027626 3624735.5801580804 1.0 2.1496954794890306 2.1284815011968643 20.699619773929275 -10.214925957842066 5.349621267332447 0.9999281112623911 2.1390884903427456 0.9997399374533973 0.008660570372374079 7.4268849412891545e-06 1.0899347463671964e-06 0.008386083828822982 0.0027951870683098376 6.096408250506827e-11 10.214925957842066 1.1391603790803546 GVLK(ub)VGQEIEVRPGIVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVLKVGQEIEVRPGIVSK 18 2 P41091 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 34536200.0 4333900.0 4672300.0 25530000.0 True False 6574843.1505304435 3838491.560153476 20483984.309803512 1.0 0.5838149248995841 3.115509197835527 22.648525047204245 -6.864709912597792 1.1617888585791067 0.7707132129598746 3.249558018265118 0.9591080712348984 0.22414915892417858 0.14202382581563278 0.36163759259925793 0.15017126027492905 0.3526001954874031 1.3654949156392584e-07 6.864709912597792 2.4788448053052434 up GVLK(ub)VGQEIEVRPGIVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVLKVGQEIEVRPGIVSK 18 2 P41091 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 27682300.0 4333900.0 4834400.0 18514000.0 True False 5610318.983940846 4565361.390220861 15144641.969682021 1.0 0.8137436397625332 2.699426184684422 22.419651369296695 -6.882619609531232 1.0651302279106831 0.8800389310822433 2.8399355947603557 0.9757357734688021 0.13216015052982263 0.12533275429201404 0.2585046417849388 0.09534767547825475 0.2321792558415672 1.310329113453025e-07 6.882619609531232 1.9598966636781125 up GVLLFGPPGTGK(ub)TLCAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVLLFGPPGTGKTLCAR 17 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 14695200.0 1649100.0 3817100.0 9229000.0 True False 2161986.069907116 3247603.5589392628 8274071.610819184 1.0 1.5021389842159287 3.827069806779402 21.043925796864514 -6.941533437352467 0.6451391758338446 0.9744372975114172 4.483364593518593 0.9983579422289273 0.04990403185374239 0.08707396734716685 0.05147565192766267 0.04916203802738396 0.19878924722188357 1.1441067889562915e-07 6.941533437352467 3.508927296007176 up GVLLFGPPGTGK(ub)TLCAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVLLFGPPGTGKTLCAR 17 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 153536300.0 5180300.0 27566000.0 120790000.0 True False 7858893.830658945 22646631.925858963 96915803.5558623 1.0 2.8816564282253587 12.331990435826537 22.90589483125723 -6.939706046895641 0.6622949625978902 0.8933684195575546 14.858536842359584 0.9981251078755087 0.2146949001699637 0.08790108478876384 0.05522281604660246 0.20852627619633937 0.8144310858227016 1.148931014673788e-07 6.939706046895641 13.96516842280203 GVLLFGPPGTGK(ub)TLCAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVLLFGPPGTGKTLCAR 17 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 28223100.0 1649100.0 3576000.0 22998000.0 True False 2258816.8352518096 3418000.4957493674 17566346.0586777 1.0 1.5131817872113273 7.776790833383101 21.107135858387405 -6.923149881790048 0.8010148276255766 0.8768507860637131 8.86386259966796 0.9950121803412381 0.2175787932214181 0.09635370636220714 0.09626783160891884 0.1906642941369717 0.5895279998348508 1.1935761116691453e-07 6.923149881790048 7.987011813604248 up GVLLFGPPGTGK(ub)TLCAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVLLFGPPGTGKTLCAR 17 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 106230300.0 5180300.0 26689000.0 74361000.0 True False 6706000.468979146 25203733.68848349 60828061.00829239 1.0 3.7583853155203033 9.070691433690317 22.677021153349678 -6.960776786897224 0.4243452920242404 0.7758852054927854 12.25502010998337 0.9997979304119473 0.04761188645470306 0.07942480508449828 0.020114696264908184 0.06893108436316042 0.4416961647611295 1.0945187684378692e-07 6.960776786897224 11.479134904490584 GVLLMLFGGVPK ddPTM_RPMI8226_Bortezomib_1h_R1 2 GVLLMLFGGVPK 12 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 295933180.0 115540670.0 120208960.0 60183550.0 False True 151474937.2674399 102274251.73885617 53956333.56737629 1.0 0.6751892661839075 0.3562063437076228 27.174503867179205 -7.2440654834314335 0.25654013321815594 1.1084876440026672 1.8919827184548965e-11 0.999950898766999 0.0018417092279921423 0.09719143100970641 0.014634583162263997 0.012939372856654698 0.042681381911594166 5.7007830872394366e-08 7.2440654834314335 -1.1084876439837474 down GVLLMLFGGVPK ddPTM_RPMI8226_Bortezomib_2h_R1 2 GVLLMLFGGVPK 12 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 900258660.0 409330000.0 217162060.0 273766600.0 False True 396336043.2059138 303876003.04318243 202058914.63804573 1.0 0.766713016018343 0.509817156682536 28.562148932536314 -6.9698853627179655 0.2609126382400296 1.0713248151171617 0.19757458339930217 0.9999814730149463 0.0008616739235620123 0.07633993788670827 0.009163300295393905 0.005331317971110871 0.02420549959677619 1.0718021830529544e-07 6.9698853627179655 -0.8737502317178596 GVLLMLFGGVPK ddPTM_RPMI8226_Bortezomib_8h_R1 2 GVLLMLFGGVPK 12 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 959996300.0 266107300.0 340093000.0 353796000.0 False True 403704229.1495301 279400746.99126256 283868065.5257042 1.0 0.6920926926623151 0.7031585131612799 28.5887234594697 -10.101405642170164 5.208475178043754 1.0000063130382746 0.6976256029113963 0.9989965328370096 0.004517602302683095 3.3118170105744266e-07 5.7142230201872896e-08 0.004374240912831459 0.0014580498733883372 7.917614595215897e-11 10.101405642170164 -0.3023807101268783 GVLLMLFGGVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GVLLMLFGGVPK 12 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 804093320.0 115540670.0 220570550.0 467982100.0 False True 158259178.06820318 210825013.7717312 357454366.3738891 1.0 1.3321503140934696 2.258664367761603 27.237713928702096 -6.953074196340835 0.5240082794867645 0.9847297855779313 2.647716221521695 0.9994209772840491 0.012815952782135355 0.08227428209834649 0.0310315026056125 0.014427920717397312 0.07656265687896592 1.1141041799987677e-07 6.953074196340835 1.6629864359437638 up GVLLMLFGGVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 GVLLMLFGGVPK 12 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 806354200.0 409330000.0 166627200.0 230397000.0 False True 340376031.3936445 165729546.2006902 278571947.4646335 1.0 0.4869013412082009 0.8184241009099297 28.34255420797059 -10.068792462237525 7.20624343689499 1.000000067646153 0.6526627210590689 0.5940857476934744 0.13534359989809303 1.472000744189404e-07 1.896848967370706e-08 0.13104590249066825 0.04368195903508948 8.535078852576237e-11 10.068792462237525 -0.34733734658708404 GVLLMLFGGVPK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GVLLMLFGGVPK 12 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 763362500.0 266107300.0 228365100.0 268890100.0 False True 344481145.60909134 215656381.43594337 219954860.8454141 1.0 0.626032467044408 0.63851059382801 28.35984978156215 -10.122218517795952 5.453500010924037 1.0000060054526445 0.632271530436095 0.9991371581299054 0.005094173927997685 3.7197045033168847e-07 5.986830146687701e-08 0.004932493222957372 0.001644137565426863 7.54712394182542e-11 10.122218517795952 -0.36773447501654954 GVLLYGPPGTGK(ub)TLLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVLLYGPPGTGKTLLAR 17 1 P62195;J3QQM1;J3QRW1;J3QRR3;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 10006700.0 1872600.0 3357300.0 4776800.0 True False 1813155.338009418 4697887.398088216 3525612.7790717226 1.0 2.5910010574415625 1.9444626200325092 20.790071099356997 -10.421297828140835 5.6892575069583335 0.9993533910343266 2.2677318387370384 0.8367695950470686 0.263948211791432 0.0021657472208887496 0.00022029611531713782 0.2556785760656711 0.08518891904411904 3.79054949550456e-11 10.421297828140835 1.2683784477027118 GVLLYGPPGTGK(ub)TLLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVLLYGPPGTGKTLLAR 17 1 P62195;J3QQM1;J3QRW1;J3QRR3;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 7676900.0 1872600.0 4485500.0 1318800.0 True False 1557149.870245864 4461335.721197959 1594554.9825577522 1.0 2.8650650823311845 1.024021523571127 20.570476374791273 -6.643213559628289 2.033257980008598 2.216697260858423 1.0317792592992123 0.16688024337188334 0.7973756632285885 0.5253181368249481 4.154679091451316 0.31895731784113357 0.8827795871346553 2.2739789511665383e-07 6.643213559628289 -1.1849180015592105 GVLSGEECK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVLSGEECKK 10 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BT54;H3BMG4;Q9NVI1-4 Q9NVI1 FANCI Fanconi anemia group I protein 1 18948710.0 655010.0 1920700.0 16373000.0 True False 993698.0576452945 1577936.0785024045 13136869.37345917 1.0 1.5879432050431326 13.220182199599751 19.922448019471048 -6.91739542478085 0.8438291522311808 0.7184695355863325 14.98797463204696 0.9934261203252844 0.4562496425627751 0.09972835951290768 0.11373773416245023 0.3877780468155018 1.1341516556861349 1.2094963865573544e-07 6.91739542478085 14.269505096460627 up GVLSGEECK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVLSGEECKK 10 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BT54;H3BMG4;Q9NVI1-4 Q9NVI1 FANCI Fanconi anemia group I protein 1 24700010.0 655010.0 0.0 24045000.0 True False 847923.35717739 0.0 19669056.72253452 1.0 0.0 23.196738898678138 19.693574341563497 -6.896091441214252 0.9857606761811842 3.1196897980078194e-15 25.44626915497738 0.9849831140008469 1.3120883016115616 0.11319988156677642 0.19221208832787273 1.009187931307828 2.5775455498100137 1.2703066124968915e-07 6.896091441214252 25.446269154977376 up GVLSQAMVMCASSPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVLSQAMVMCASSPEK 16 0 Q12904;Q12904-2;A0A5F9ZHC5 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 0 6522400.0 1304700.0 3044200.0 2173500.0 False True 1710474.3347327744 2590017.2261986625 1948607.0696842 1.0 1.5142099320673514 1.139220291188192 20.705965026290823 -10.188000517792247 9.53756934775609 0.9999999941161373 1.3267151116277716 0.5030155670111203 0.15308887983057481 1.9295252032347175e-08 1.3895140681914863e-09 0.14822767272710313 0.04940922350611375 6.486336602073496e-11 10.188000517792247 0.3267151175116343 GVLSQAMVMCASSPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVLSQAMVMCASSPEK 16 0 Q12904;Q12904-2;A0A5F9ZHC5 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 0 3745000.0 1304700.0 0.0 2440300.0 False True 1787082.8481917654 0.0 1863951.3995560969 1.0 0.0 1.043013423491871 20.769175087813714 -10.497794458692407 5.022745312404527 1.0014368959540443 0.52150671174592 0.2191250912287671 0.4258084470714733 0.006870111185860402 0.0006869158305504173 0.41341023377436587 0.1374290853485135 3.178377965868009e-11 10.497794458692407 -0.4799301842081243 GVLVVGIGSGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVLVVGIGSGTK 12 0 Q8WWH5 Q8WWH5 TRUB1 Probable tRNA pseudouridine synthase 1 0 5362400.0 1583100.0 1944200.0 1835100.0 False True 2075459.4307622055 1654132.9384322432 1645221.4555221875 1.0 0.7969960356318642 0.7927022957601177 20.98499930101987 GVMLAVDAVIAELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVMLAVDAVIAELK 14 0 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 34545500.0 8442300.0 16711900.0 9391300.0 False True 12807586.31480263 13729530.874329345 7535105.438646986 1.0 1.0719842550240055 0.5883314196319828 23.610495278863127 -6.869032857096815 1.139259130776447 1.040479622859642 0.5605293047244714 0.9637052864485922 0.0405915058341319 0.1377823957136727 0.3348432364350273 0.027668364454570916 0.06539543841380349 1.3519702743085525e-07 6.869032857096815 -0.47995031813517064 GVMLAVDAVIAELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVMLAVDAVIAELK 14 0 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 23474100.0 8442300.0 9120600.0 5911200.0 False True 10928723.772612143 8613030.59234825 4835422.25403394 1.0 0.7881094601304572 0.4424507705237933 23.381621600955576 -6.963825151168035 0.3776731535454625 1.0243734127082795 0.19400844710441945 0.9998868409047016 0.002444433095391263 0.07836191714285903 0.016279731487274088 0.0045097842550301534 0.029240873890189707 1.086863111321293e-07 6.963825151168035 -0.8303649656038601 down GVMLAVDAVIAELKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVMLAVDAVIAELKK 15 1 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 8525290.0 4718700.0 2723490.0 1083100.0 False True 4568907.451385795 3810993.7598127285 799403.6176964865 1.0 0.8341148951609462 0.17496603426581106 22.123417788675297 -6.993749292174861 0.6363458826489767 1.0051763491302639 1.2449068218923067e-22 0.9987013878369804 0.012840443163299919 0.07809109734481871 0.04659509316675465 0.013043596635037505 0.050152781115114065 1.0144968615223865e-07 6.993749292174861 -1.0051763491302639 down GVMLAVDAVIAELKK ddPTM_RPMI8226_Bortezomib_8h_R1 2 GVMLAVDAVIAELKK 15 1 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 161605500.0 24703300.0 79216100.0 57686100.0 False True 37476712.153141156 65079368.0367857 46284417.05028414 1.0 1.736528214397564 1.2350180789913492 25.159491054550664 -10.214644228451522 4.130714646240107 0.9997312880075242 1.4857731465822468 0.5557467471470005 0.20474065562575858 72067444.77384211 95.0497893148984 189812.9468319099 0.07008817217350344 6.100364309497458e-11 10.214644228451522 0.4860418585747226 GVMLAVDAVIAELKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVMLAVDAVIAELKK 15 1 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 5980100.0 4718700.0 0.0 1261400.0 False True 3923808.1238540835 0.0 1525152.907945368 1.0 0.0 0.38869202055867 21.903823064109574 -10.676434324545355 6.637053873261863 1.0057362192499977 0.19434601027934412 0.851373713472203 0.15868285291002174 0.013461168277946996 0.0006562496538721887 0.1535555270416215 0.051214670554099596 2.1065204299250328e-11 10.676434324545355 -0.8113902089706535 GVMLAVDAVIAELKK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GVMLAVDAVIAELKK 15 1 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 89650300.0 24703300.0 34931000.0 30016000.0 False True 31978908.824842684 32987059.143183157 24553395.990168314 1.0 1.031525475864808 0.76779968086635 24.930617376643113 -6.877055901006207 1.0961416659395322 1.018870429961963 0.7501374576798397 0.9712295737072836 0.01994667474010506 0.13026731276541736 0.28834808226733694 0.014053328784554982 0.033742971961071934 1.3272236107271865e-07 6.877055901006207 -0.26873297228212334 GVNLPGAAVDLPAVSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVNLPGAAVDLPAVSEK 17 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 141780000.0 12875000.0 65909000.0 62996000.0 False True 16879249.681677338 56075634.111269735 56477778.22030172 1.0 3.3221639094621973 3.3459886716178584 24.008747438838263 -10.563031103893756 0.8451483086078001 1.8963366659367118e-15 3.340537361463308 0.9999853707934688 0.004208581433778851 2.0814606880276725 0.4599606248523344 4.513518995362155 0.003346451709015954 2.7350728351202536e-11 10.563031103893756 3.3405373614633063 GVNLPGAAVDLPAVSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVNLPGAAVDLPAVSEK 17 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 137358000.0 40372000.0 22380000.0 74606000.0 False True 39090412.95851548 31316450.71015818 55064450.467975385 1.0 0.8011286742709169 1.4086433552495923 25.220311489822507 -6.818523545967792 1.3782006215134017 0.8926459096292416 1.421495877925762 0.8809626553902578 0.08725408397735061 0.1954085207529541 0.7297101099381728 0.04975516475535049 0.11472803973548329 1.5187156002119238e-07 6.818523545967792 0.5288499682965204 GVNLPGAAVDLPAVSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVNLPGAAVDLPAVSEK 17 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 236206800.0 3751600.0 224330000.0 8125200.0 False True 5691451.4786981745 184296558.80171028 6519250.65859833 1.0 32.38129315368688 1.1454460576530296 22.440365196210635 -3.462157155836946 16.026524127551124 9.999999999999998 15.9299330100647 0.0 14.83605303249715 0.0 0.0 4.84318554883213 0.0 0.000345018866599383 3.462157155836946 5.929933010064701 GVNLPGAAVDLPAVSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVNLPGAAVDLPAVSEK 17 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 133979000.0 12875000.0 66307000.0 54797000.0 False True 17635235.43379239 63377337.49207312 41855077.17964003 1.0 3.5937902689198213 2.3733778512215338 24.071957500361155 -9.060001104607004 12.874753305906133 0.9999852275925544 2.9835840600694827 0.7788737315694475 0.49823128325921373 0.0 0.0 0.4824103656226282 0.1608034552075427 8.709613747051437e-10 9.060001104607004 1.9835988324769285 GVNLPGAAVDLPAVSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVNLPGAAVDLPAVSEK 17 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 51981900.0 40372000.0 6293600.0 5316300.0 False True 33571106.78285053 6259695.127618212 6427913.750206088 1.0 0.18646079106381788 0.191471606574786 25.000716765256783 -10.061446776592955 4.913703434536426 1.0000197942325857 0.18896619881222912 0.9999713719862443 0.0020456568908554704 2247960.5058250823 1150747.9713578161 454.9817955965963 0.0007002827690509391 8.680669536149567e-11 10.061446776592955 -0.8110535954203566 GVNLPGAAVDLPAVSEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVNLPGAAVDLPAVSEK 17 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 15628700.0 3751600.0 5741700.0 6135400.0 False True 4856520.1550918305 5422169.347640058 5018820.154520205 1.0 1.1164721188184858 1.0334189901916109 22.211491518303085 -10.331723664832055 5.713714299844283 0.9999886133605974 1.0749455545050446 0.5205496301726995 0.03390629777959848 4.918953355471917e-06 5.75274209898332e-07 0.0328346191011418 0.010943210552661002 4.658824333497939e-11 10.331723664832055 0.07495694114444718 GVNPSLVSWLTTMMGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVNPSLVSWLTTMMGLR 17 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;H0Y710;H0Y4L1 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 0 1107920000.0 378910000.0 449700000.0 279310000.0 False True 574834172.0315396 369447521.47786313 224104256.07407808 1.0 0.6427027818687031 0.3898589662511958 29.098570586995493 -7.986994846474835 0.17954734294653077 1.2873855957281037 2.666628638822224e-12 0.9998995710283535 0.002508384146912839 0.10622078272249795 0.030476739556593545 0.08242413128454525 0.10590500995603967 1.0303983475191605e-08 7.986994846474835 -1.2873855957254372 down GVNPSLVSWLTTMMGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVNPSLVSWLTTMMGLR 17 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;H0Y710;H0Y4L1 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 0 997960000.0 378910000.0 215490000.0 403560000.0 False True 490506464.4327339 203497792.0690662 330116220.87527674 1.0 0.41487280357132394 0.6730109485041202 28.869696909087942 -10.38169559295217 5.952602378099573 1.0000951699656648 0.543941876037733 0.8062668120885363 0.10538445637232821 0.00013312975535807598 1.3828197383776211e-05 0.1020591796099961 0.03401268703992892 4.152449954768316e-11 10.38169559295217 -0.4561532939279318 GVNSLSQSLSANPLTASTLVHLDLSGNVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVNSLSQSLSANPLTASTLVHLDLSGNVLR 30 0 Q5VZK9-2;Q5VZK9;Q5VZK9-3 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 0 60401000.0 20396000.0 20745000.0 19260000.0 False True 30942223.147331264 17042892.6685752 15453252.558042122 1.0 0.5507972904023586 0.49942282700443097 24.883073519964444 -13.999999999999998 0.30604737993985653 5.24322358387927 0.4875569030223455 0.9996632751846636 0.004125927003830338 16.993125632376948 0.17588255939831446 45.81674101204346 0.018096585580497915 1.0000000000000041e-14 13.999999999999998 -4.755666680856924 GVNSYPSLFIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVNSYPSLFIFR 12 0 Q8IXB1;Q8IXB1-2;E7EP04;A0A494C1G5;Q8IXB1-3 Q8IXB1 DNAJC10 DnaJ homolog subfamily C member 10 0 19011700.0 4649100.0 7068400.0 7294200.0 False True 6095015.12194845 6013822.272407407 6539466.154907059 1.0 0.9866788108123533 1.072920415136973 22.53919836955161 -6.867462762630352 1.147351092318208 0.9925692533059994 1.077735191171 0.9620890264322867 0.007380768433304228 0.13931525590170613 0.34434246113369016 0.004999493142779134 0.01178780346593414 1.356866866079177e-07 6.867462762630352 0.0851659378650006 GVNSYPSLFIFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVNSYPSLFIFR 12 0 Q8IXB1;Q8IXB1-2;E7EP04;A0A494C1G5;Q8IXB1-3 Q8IXB1 DNAJC10 DnaJ homolog subfamily C member 10 0 14844900.0 6226800.0 2322300.0 6295800.0 False True 6029133.642377991 3249606.500634511 4646741.110048513 1.0 0.5389839889753733 0.7707145645913664 22.523519277976533 -10.171697239495174 5.702953256845734 1.0000065198388437 0.6548492767833535 0.7473434320276838 0.09460361134349422 7.842559155685797e-06 1.1388184608853068e-06 0.09160128288723846 0.03053318426869425 6.734459732979093e-11 10.171697239495174 -0.3451572430554902 GVNSYPSLFIFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVNSYPSLFIFR 12 0 Q8IXB1;Q8IXB1-2;E7EP04;A0A494C1G5;Q8IXB1-3 Q8IXB1 DNAJC10 DnaJ homolog subfamily C member 10 0 21712300.0 4649100.0 7407900.0 9655300.0 False True 6367997.907203448 7080594.4833505945 7374916.997145428 1.0 1.1119027654423475 1.1581217683509222 22.6024084310745 -13.999999999999995 0.12142569355208799 0.46716482496609296 1.230492679224143 0.999685968647799 0.0011763631357830748 11.958677609705072 0.10742527002779657 1.534826595369948 0.06422978001906411 1.0000000000000123e-14 13.999999999999995 0.7633278542580502 GVNSYPSLFIFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVNSYPSLFIFR 12 0 Q8IXB1;Q8IXB1-2;E7EP04;A0A494C1G5;Q8IXB1-3 Q8IXB1 DNAJC10 DnaJ homolog subfamily C member 10 0 14216000.0 6226800.0 4060600.0 3928600.0 False True 5177860.094012031 4038724.741834008 4750052.096205937 1.0 0.77999881582444 0.9173774512948243 22.30392455341081 -10.3838406468928 5.397454448461155 1.0000714789248037 0.8486881336218429 0.6179571644530181 0.05608459307705099 4.8263661098808816e-05 5.509594903727105e-06 0.0543292840170892 0.01810122458051865 4.131990868769819e-11 10.3838406468928 -0.15138334530296083 GVNVSALSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVNVSALSR 9 0 P38606;P38606-2;C9JVW8;C9JA17 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 7498200.0 2461400.0 2717900.0 2318900.0 False True 3226919.2362315063 2312399.9142912203 2078962.4724594844 1.0 0.716596773891283 0.6442561217885823 21.62172603963543 -13.999999999999996 0.19173112181390667 2.528407868328089 0.5932525658290536 0.9994885479595533 0.0034718048377032867 12.379396151701574 0.1388587106699997 7.072903526227569 0.049073165048727545 1.0000000000000082e-14 13.999999999999996 -1.9351553024990356 GVNVSALSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVNVSALSR 9 0 P38606;P38606-2;C9JVW8;C9JA17 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 5968250.0 2111500.0 538050.0 3318700.0 False True 2044471.5882766629 752896.1708936833 2449432.91113409 1.0 0.36825954207968165 1.198076278085517 20.963296583405292 -6.703169308444068 1.819591222728632 0.6089544717032057 1.1957640459481684 0.4327453600838689 0.2665112091029666 0.38889946831258365 2.505444110792411 0.11675430258848589 0.2990894836564427 1.980754683799073e-07 6.703169308444068 0.5868095742449627 GVNVSALSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVNVSALSR 9 0 P38606;P38606-2;C9JVW8;C9JA17 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 8028200.0 2461400.0 2354700.0 3212100.0 False True 3371446.096833913 2250661.5680483878 2453468.135276048 1.0 0.667565639018212 0.7277198166033478 21.68493610115832 -10.671507670612009 6.677427480923518 1.0019365856570115 0.6976427278107824 0.9711698289360386 0.024557840163391343 0.0007119112334271341 3.50220224202641e-05 0.023909128446100974 0.00792600883096986 2.13055293687978e-11 10.671507670612009 -0.3042938578462291 GVNWAAFHPTMPLIVSGADDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVNWAAFHPTMPLIVSGADDR 21 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1;A0A3B3IU78 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 7649700.0 1844900.0 3844200.0 1960600.0 False True 2418681.7660370134 3270660.3445742344 1757735.9194031924 1.0 1.3522491426944436 0.726733026264644 21.205789530968374 -6.753911543882546 1.6353311893613498 1.206148731643366 0.7251067049967589 0.6656342183244898 0.14805557250909848 0.29327614310504746 1.544245435236867 0.07148408753469765 0.17283994829819968 1.7623349582561115e-07 6.753911543882546 -0.481042026646607 GVNWAAFHPTMPLIVSGADDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVNWAAFHPTMPLIVSGADDR 21 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1;A0A3B3IU78 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 14371500.0 1844900.0 4382800.0 8143800.0 False True 2527009.3865478532 4189153.4040185455 6220402.166825782 1.0 1.6577514220243348 2.4615667040807754 21.268999592491266 -6.968438856281259 0.2930899420721416 0.8486328564085467 3.2956273009278316 0.999967513509135 0.003406555724079735 0.07681263211533694 0.010834076267042187 0.013814438065121505 0.0726368859648146 1.0753779907136989e-07 6.968438856281259 2.446994444519285 GVPTGFILPIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVPTGFILPIR 11 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 9875000.0 2328000.0 3289900.0 4257100.0 False True 3052030.5443840674 2799059.7439297615 3816616.1289867023 1.0 0.917113935533906 1.2505170159615608 21.541337969901242 -6.840899612898539 1.278237568995872 0.9559111154541027 1.2616778675288027 0.9259870800025836 0.03855808845788973 0.1677495076596258 0.5320268039747622 0.023649965451414325 0.054497924740052765 1.4424487347917302e-07 6.840899612898539 0.30576675207470005 GVPTGFILPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVPTGFILPIR 11 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 9871600.0 2328000.0 3141000.0 4402600.0 False True 3188724.5118344626 3002220.2341019996 3362796.554393177 1.0 0.941511323088501 1.0545898656069763 21.604548031424134 -6.76611385389552 1.5892020759261547 0.9662863383047134 1.0551364307964517 0.7155195671270154 0.024627299882052898 0.27276215233778467 1.3588747911887673 0.012218997327656161 0.029192713827244265 1.7135080382966272e-07 6.76611385389552 0.08885009249173825 GVPWNFTFNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVPWNFTFNVK 11 0 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8 P11171 EPB41 Protein 4.1 0 11520200.0 2923100.0 4295200.0 4301900.0 False True 3832212.4073406644 3654372.9025584674 3856780.654738656 1.0 0.95359351573479 1.0064109826874237 21.86974609661027 -6.674666229890723 1.9208869375875817 0.97049837374546 1.0062021219653556 0.29984421854266363 0.019691564709145352 0.45049732176444257 3.208959880517079 0.008240061632420682 0.02188187532915452 2.1151139525078732e-07 6.674666229890723 0.03570374821989564 GVPWNFTFNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVPWNFTFNVK 11 0 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8 P11171 EPB41 Protein 4.1 0 18243000.0 6647400.0 4558100.0 7037500.0 False True 6436381.92560279 6378173.10017748 5194167.629525458 1.0 0.9909562816349096 0.807001152132377 22.617818505364554 -6.917128711805212 0.8457619838805053 1.0044938523499467 0.7792123318210425 0.9933451944141588 0.007254279269262945 0.09989052716071042 0.1145904776291812 0.006157077396494041 0.01796582275954125 1.2102394018833604e-07 6.917128711805212 -0.22528152052890416 GVPWNFTFNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVPWNFTFNVK 11 0 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8 P11171 EPB41 Protein 4.1 0 15311200.0 2923100.0 4327700.0 8060400.0 False True 4003849.063807267 4136487.904209878 6156699.529148869 1.0 1.033127832315558 1.537695210541841 21.932956158133162 -6.920237442275975 0.8229456575877033 0.9889628928396963 1.6195124610605351 0.9942472091143306 0.018661102488219318 0.0980316221043978 0.10488504761250995 0.016098860824783817 0.04833508412760981 1.2016072989811751e-07 6.920237442275975 0.6305495682208389 GVPWNFTFNVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVPWNFTFNVK 11 0 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8 P11171 EPB41 Protein 4.1 0 16355300.0 6647400.0 3908700.0 5799200.0 False True 5527607.629751328 3887643.0572837987 7011785.907528759 1.0 0.7033138597535898 1.268502827478042 22.39822378079883 -6.764055267962788 1.597020191554294 0.8285395994701885 1.2710053933247423 0.7073625801453592 0.12487137322757869 0.27616123299707834 1.3889968681404088 0.061664768986632444 0.1476139459733826 1.7216494653327818e-07 6.764055267962788 0.44246579385455376 GVQDIVVGEGTHFLIPWVQKPIIFDCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVQDIVVGEGTHFLIPWVQKPIIFDCR 27 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2;D6RBK0 P35232 PHB Prohibitin 0 359520000.0 96421000.0 92753000.0 170346000.0 False True 146277706.3193188 76200502.46750332 136677038.43469575 1.0 0.520930389085815 0.9343668414948677 27.124134669153822 -10.177671086961233 7.771424431743597 1.0000001107803114 0.7276486152903416 0.36652834589486105 0.16878472491144003 3.239735093962467e-07 3.431252977603339e-08 0.1634251741370807 0.0544750357230173 6.642459467915675e-11 10.177671086961233 -0.27235149548996973 GVQDIVVGEGTHFLIPWVQKPIIFDCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVQDIVVGEGTHFLIPWVQKPIIFDCR 27 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2;D6RBK0 P35232 PHB Prohibitin 0 178355700.0 96421000.0 38998800.0 42935900.0 False True 124818885.24205917 36828482.49729963 35122006.75953717 1.0 0.2950553710352305 0.2813837560832694 26.89526099124627 GVQGIIVVNTEGIPIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVQGIIVVNTEGIPIK 16 0 Q9NP97;B1AKR6 Q9NP97 DYNLRB1 Dynein light chain roadblock-type 1 0 77769000.0 16837000.0 34957000.0 25975000.0 False True 25542959.949579112 28718650.229712386 20841029.86475307 1.0 1.124327418842686 0.8159207040175656 24.606422380213232 -6.797269826037421 1.466909329073702 1.0688363293968894 0.811938854117804 0.8240954630715039 0.05313575478301219 0.22467778780845463 0.9547216641334549 0.02849960762344234 0.06639649880504553 1.5948879396027942e-07 6.797269826037421 -0.25689747527908546 GVQGIIVVNTEGIPIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVQGIIVVNTEGIPIK 16 0 Q9NP97;B1AKR6 Q9NP97 DYNLRB1 Dynein light chain roadblock-type 1 0 54680000.0 16837000.0 24201000.0 13642000.0 False True 21795828.406887997 22854193.07561127 11159295.978740547 1.0 1.0485581299763218 0.5119922845058711 24.37754870230568 -6.884796465800208 1.0526501400502637 1.0325280452296242 0.4702821368391206 0.9773543225057384 0.03646345947340715 0.12346777096057573 0.24731162154733563 0.026557112122485217 0.06508263728116838 1.303777656971328e-07 6.884796465800208 -0.5622459083905036 GVQK(ub)LVLTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVQKLVLTSR 10 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 2236100.0 0.0 807200.0 1428900.0 True False 0.0 686768.9064409566 1281051.1349766527 0.0 GVQK(ub)LVLTSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVQKLVLTSR 10 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 5620510.0 799600.0 1161110.0 3659800.0 True False 774217.1356789116 1624747.278108661 2701188.588353437 1.0 2.0985679639910306 3.488928963041825 19.562378713461257 -6.967926702791151 0.30365203644377997 0.7690947845712337 4.862195665596926 0.9999613953524206 0.006327746471249405 0.07698134006033482 0.011425370488735879 0.022658941789894447 0.12422136621399017 1.0766469072904777e-07 6.967926702791151 4.093100881025692 GVQK(ub)LVLTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVQKLVLTSR 10 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 2083030.0 0.0 412270.0 1670760.0 True False 0.0 394054.5482054224 1276160.898382309 0.0 GVQK(ub)LVLTSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVQKLVLTSR 10 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 4619300.0 799600.0 2157420.0 1662280.0 True False 664902.8282861221 2145797.5502456566 2009855.0624856686 1.0 3.2272348062900305 3.0227801371613126 19.342783988895533 -9.86577091971884 6.22550207617571 0.9999998156818021 3.12500747172626 0.9931050740002643 0.08346826915125725 2.1386036831887828e-07 3.907547120784023e-08 0.08081781131405762 0.026939268029655652 1.3621630024374917e-10 9.86577091971884 2.125007656044458 GVQK(ub)LVLTSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVQKLVLTSR 10 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 10082670.0 2845900.0 862170.0 6374600.0 True False 3684073.651075762 814189.4815916602 5214488.208919468 1.0 0.2210024985124589 1.41541367051574 21.81287047303888 -6.730721420703875 1.7207964506546158 0.5315790097802547 1.414773852807354 0.5625490733016332 0.32745264285389636 0.3348726568827601 1.943012030626483 0.15078486451347775 0.37382909508416434 1.8589965307570773e-07 6.730721420703875 0.8831948430270992 GVQLQTHPNVDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVQLQTHPNVDKK 13 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 0 6144840.0 786840.0 3194600.0 2163400.0 False True 1031554.8597693997 2717978.1324532656 1939552.1207981568 1.0 2.634836244250606 1.8802219798874646 19.97638911746342 -10.09771334465018 4.5604958806745755 0.999912284999569 2.2575291121050465 0.7873586224705467 0.3080699835671606 24082391.330655936 26661280.09666704 19063.396492405427 0.10546054730559175 7.985215761998579e-11 10.09771334465018 1.2576168271054775 GVQLQTHPNVDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVQLQTHPNVDKK 13 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 0 5747040.0 786840.0 2419400.0 2540800.0 False True 1077756.0115514742 2312502.9081140975 1940715.3694185717 1.0 2.1456645876511087 1.800700110802288 20.03959917898631 -10.098768957149177 4.59868470080972 0.9999412990319444 1.9731823490154785 0.913878781938871 0.1408311581781014 98018707.90749875 9.98598833110013 72422.09927034132 0.04821025129712751 7.965830165514111e-11 10.098768957149177 0.9732410499835341 GVQVETISPGDGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVQVETISPGDGR 13 0 P62942;A0A087WZM5;Q1JUQ3;A0A087WTS4;A0A087WV48 P62942 FKBP1A;FKBP12-Exin Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 28281600.0 2701400.0 15971000.0 9609200.0 False True 3541561.5603948156 13588189.054470392 8614932.161955105 1.0 3.836779009131659 2.4325236241254853 21.755954189150902 -9.010260755488414 10.862290352460262 1.0000004594138472 3.1346513166164027 0.7549657392330056 0.5732848603127634 177999843.6200906 0.0 0.5550806708804977 0.19625065616695037 9.7665065240308e-10 9.010260755488414 2.1346508572025558 GVQVETISPGDGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVQVETISPGDGR 13 0 P62942;A0A087WZM5;Q1JUQ3;A0A087WTS4;A0A087WV48 P62942 FKBP1A;FKBP12-Exin Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 25928900.0 6588800.0 2666100.0 16674000.0 False True 6379642.150526772 3730687.63352783 12306579.19072222 1.0 0.5847800778637379 1.929039106010994 22.605044071348882 -6.823758369997937 1.3555592552738616 0.7770123163517596 1.9608146984438626 0.8928099834926758 0.18399678885702153 0.18863857777773246 0.6800642297572718 0.10663588588274776 0.24556419225199463 1.500519452772305e-07 6.823758369997937 1.1838023820921029 GVQVETISPGDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVQVETISPGDGR 13 0 P62942;A0A087WZM5;Q1JUQ3;A0A087WTS4;A0A087WV48 P62942 FKBP1A;FKBP12-Exin Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 28871400.0 2701400.0 12115000.0 14055000.0 False True 3700180.582590047 11579719.241052458 10735498.471811242 1.0 3.129501110172008 2.9013444701384343 21.819164250673794 -9.952820787838126 7.23660492208444 0.9999999469133315 3.0154227901552226 0.990479914846411 0.09314455825169152 7.993533275346302e-08 1.151383735126917e-08 0.09018683341236401 0.030062276908219734 1.1147544435112503e-10 9.952820787838126 2.015422843241891 GVQVETISPGDGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVQVETISPGDGR 13 0 P62942;A0A087WZM5;Q1JUQ3;A0A087WTS4;A0A087WV48 P62942 FKBP1A;FKBP12-Exin Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 8609020.0 6588800.0 1300700.0 719520.0 False True 5478879.13333116 1293692.870931264 869968.3053154033 1.0 0.23612363759970342 0.15878581807415457 22.385449346783158 -13.999999999999998 0.3236854786634266 9.006203089831045 0.14405557768475863 0.9997015888519324 0.0065580960473106565 18.303889883694048 0.18161063056398388 99.43468280636621 0.025383199243522944 1.0000000000000041e-14 13.999999999999998 -8.862147512146286 GVQVETISPGDGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVQVETISPGDGR 13 0 P62942;A0A087WZM5;Q1JUQ3;A0A087WTS4;A0A087WV48 P62942 FKBP1A;FKBP12-Exin Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 6540800.0 1576100.0 3029300.0 1935400.0 False True 2040292.5195757076 2860716.7920312877 1583177.0588809869 1.0 1.4021111015131265 0.7759559198943782 20.960344577544102 -6.73330358667926 1.7114904825647512 1.2410960351107516 0.776118681151948 0.574404600301633 0.1689978112141883 0.33006669048273296 1.8956180865488639 0.07820829512174182 0.19332432724898768 1.847976368754668e-07 6.73330358667926 -0.4649773539588036 GVQYLNEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVQYLNEIK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 68610000.0 0.0 29610000.0 39000000.0 False True 0.0 25192303.41887602 34964654.11441629 0.0 GVQYLNEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVQYLNEIK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 40663000.0 17582000.0 0.0 23081000.0 False True 17023869.033900224 0.0 17035393.68484223 1.0 0.0 1.0006769701364042 24.021055621427994 -12.020648397487154 17.898072865100968 0.8741108791494988 0.5503046365613956 0.0 0.48576275134024943 0.0 0.0 0.0 0.1392518830037158 9.53567855089091e-13 12.020648397487154 -0.3238062425881032 GVQYLNEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVQYLNEIK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 73351000.0 0.0 36842000.0 36509000.0 False True 0.0 35214198.619798176 27886326.126457267 0.0 GVQYLNEIKDSVVAGFQWATK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVQYLNEIKDSVVAGFQWATK 21 1 P13639 P13639 EEF2 Elongation factor 2 0 126471000.0 32753000.0 32459000.0 61259000.0 False True 49688695.56503919 26666437.846675474 49151131.7992265 1.0 0.5366701126571312 0.9891813669145519 25.566414332753798 -10.841553336205038 10.41136000309029 1.0053117685834387 0.7629257397858416 0.2679209855885818 0.1847369459662505 0.022916585716861598 0.0003487584652878842 0.1799644860056005 0.05962359292970896 1.440279117048766e-11 10.841553336205038 -0.24238602879759719 GVQYLNEIKDSVVAGFQWATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVQYLNEIKDSVVAGFQWATK 21 1 P13639 P13639 EEF2 Elongation factor 2 0 64713000.0 32753000.0 15636000.0 16324000.0 False True 42399404.15815186 14765842.854851346 13353199.49838444 1.0 0.3482559047238973 0.3149383762228439 25.337540654846247 -13.617257599798155 0.42717318088644235 9.999999999997275 0.31412213427731017 0.9998673637270185 0.003632176353925351 22.138170127487964 0.2185761227047422 184.25388509158913 0.00794254467603844 2.4140285396503684e-14 13.617257599798155 -9.685877865719965 GVSAWHAAEAGGTGAGHAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVSAWHAAEAGGTGAGHAGR 20 0 F2Z3N0 F2Z3N0 AQP12B 0 1868150.0 596110.0 695180.0 576860.0 False True 816507.9762670285 664464.64894716 440617.54880462645 1.0 0.8137883134773631 0.5396365517690033 19.639107453628167 -6.965565699331656 0.3482087154541558 1.027045503065508 0.31715390476108835 0.9999243334085122 0.0016447500498848455 0.07776953034553064 0.014186121212000007 0.003780649634649316 0.023592357746181805 1.0825159415667245e-07 6.965565699331656 -0.7098915983044196 GVSGQK(ub)DGGQTESNEEGKENR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVSGQKDGGQTESNEEGKENR 21 2 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77;Q5VU81;Q5VU80;Q5VU79;Q5VU78 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 1 22673600.0 7866200.0 6972400.0 7835000.0 True False 7616491.78674019 9756515.680585667 5782778.455038292 1.0 1.2809723890953466 0.7592443630157559 22.860695203876684 -6.760413583028085 1.6107633420606462 1.1631183699654914 0.7572888234166021 0.6927228973357126 0.1181852572218136 0.28221729250704064 1.443221937119785 0.05788690891486251 0.13906293718640894 1.7361466911929562e-07 6.760413583028085 -0.40582954654888936 GVSGQK(ub)DGGQTESNEEGKENR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVSGQKDGGQTESNEEGKENR 21 2 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77;Q5VU81;Q5VU80;Q5VU79;Q5VU78 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 1 31666100.0 8079100.0 12380000.0 11207000.0 True False 12256585.361325927 10170692.274618512 8991931.5377974 1.0 0.8298145017380467 0.7336408365555287 23.547053769794907 -13.999999990522431 0.06624282962822667 2.0175036561479485 0.35588981925885294 0.9999365850513977 0.0008769933244346465 12.399383657300074 0.06817805509949143 1.997827897995863 0.3501087207967932 1.0000000218229092e-14 13.999999990522431 -1.6616138368890956 GVSGQK(ub)DGGQTESNEEGKENR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVSGQKDGGQTESNEEGKENR 21 2 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77;Q5VU81;Q5VU80;Q5VU79;Q5VU78 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 1 35690100.0 8079100.0 15205000.0 12406000.0 True False 10458554.2128698 14358828.383730812 10148235.296309572 1.0 1.3729267058788603 0.9703286983798999 23.318180091887356 -6.663390763338998 1.9614500952332115 1.2393806983094102 0.9720149524295765 0.2499398266299815 0.15865688939993774 0.4764098582599164 3.5271107979144447 0.06527969991918371 0.17588667788935622 2.1707471357865055e-07 6.663390763338998 -0.26736574587983375 GVSK(ub)AVEHINK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVSKAVEHINK 11 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 42378000.0 12080000.0 17334000.0 12964000.0 True False 15836996.982886396 14747834.7674028 11622609.639469033 1.0 0.9312267207816889 0.7338897426089385 23.9167954612054 -6.952446797831638 0.531301652144024 1.0030835061750378 0.6530546324880236 0.9993795813490784 0.0028092930287782272 0.08251783163167203 0.03200919475054283 0.0031282020669696677 0.016321509468941543 1.1157148208564181e-07 6.952446797831638 -0.3500288736870142 GVSK(ub)AVEHINK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVSKAVEHINK 11 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 73111000.0 23936000.0 23777000.0 25398000.0 True False 23176164.78190399 33271280.09541696 18745501.876332182 1.0 1.4355817888124123 0.8088267430238811 24.46613851149163 -6.7198791428126885 1.7605967926136679 1.265050873534587 0.8098666866534027 0.5115801057623657 0.18329728361868225 0.3555440685477759 2.1539361637094294 0.08268287377204435 0.20752809884880075 1.9059910509015878e-07 6.7198791428126885 -0.4551841868811842 GVSK(ub)AVEHINK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVSKAVEHINK 11 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 54199000.0 12207000.0 22098000.0 19894000.0 True False 18518911.451239064 18154439.24753793 15961942.18015004 1.0 0.980318918600545 0.8619265890534865 24.14249596313075 -6.9357832564100255 0.6977189995175022 1.0014741460810452 0.8336091680364399 0.9975573061072419 0.0030139057023249706 0.08974470701382696 0.0637781861078243 0.002847313585998379 0.010393120286678895 1.1593558121515128e-07 6.9357832564100255 -0.16786497804460532 GVSK(ub)AVEHINK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVSKAVEHINK 11 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 41147000.0 12080000.0 16061000.0 13006000.0 True False 16546302.449725218 15351371.913375456 9934250.666978082 1.0 0.9277826245482654 0.6003909753954159 23.98000552272829 -6.94201246587599 0.6405739917180432 1.0035855024552487 0.5066210938201939 0.9984157130158309 0.006920703234043025 0.08686059828702766 0.0505192157402791 0.0068442907559899 0.02793767376739291 1.1428455303777464e-07 6.94201246587599 -0.49696440863505476 GVSK(ub)AVEHINK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVSKAVEHINK 11 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 66611700.0 23936000.0 32722000.0 9953700.0 True False 19903844.54459307 32545720.091191553 12034972.649291093 1.0 1.6351474218096564 0.6046556795762568 24.246543786925905 -6.739965397477406 1.6868089554658905 1.377932404959523 0.604059453801683 0.6047518117613995 0.2668631356252647 0.3179003583732649 1.7760359020181726 0.1251563516818466 0.30713578019657045 1.819845849511756e-07 6.739965397477406 -0.7738729511578399 GVSK(ub)AVEHINK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVSKAVEHINK 11 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 44446100.0 12207000.0 22259000.0 9980100.0 True False 15802202.135943558 21020267.082766432 8163824.2044735765 1.0 1.3302112516934528 0.5166257293914884 23.913622285223198 -6.796530965932888 1.470142302528 1.1830005388542058 0.5063469055430917 0.8217961813505588 0.1410380625171584 0.2257471688059147 0.9635942343206187 0.0754867755825383 0.17593000443344162 1.5976036131512011e-07 6.796530965932888 -0.6766536333111141 GVSK(ub)EEVIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVSKEEVIR 9 1 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 11040500.0 3188800.0 3169500.0 4682200.0 True False 4180547.680383127 2696622.954614232 4197730.858833843 1.0 0.6450405929509933 1.004110269697759 21.995260526944655 -10.969336746650386 10.884413943906539 1.0813465004335991 0.8245754313269422 0.24141588941193892 0.14658958168927905 0.08259639564415487 0.0002326879602911505 0.040513630137605075 0.04731158405084076 1.0731569768069046e-11 10.969336746650386 -0.2567710691066569 GVSK(ub)EEVIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVSKEEVIR 9 1 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 28592400.0 3187700.0 7768500.0 17636200.0 True False 3086508.208358758 10870502.562192306 13016750.145340947 1.0 3.5219418930276114 4.217306181169227 21.557544197439565 -9.589083915024725 0.36811655767684054 1.1082152256679188e-19 4.3519434602808 0.9984649736394893 0.054154555074349256 0.9329255702636716 0.15320481015046084 1.3577669498518892 0.19254294500640898 2.5758234044925454e-10 9.589083915024725 4.3519434602808 GVSK(ub)EEVIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVSKEEVIR 9 1 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 8143590.0 3086500.0 846690.0 4210400.0 True False 4682446.153375069 695591.5542808357 3378212.594516121 1.0 0.14855302794661268 0.72146320189526 22.158830973358874 -10.17869215261989 6.9413105362357 1.000001124836523 0.4350081150047242 0.5645986631070107 0.23388959910388987 4.071221992967912e-06 4.817820061997661e-07 0.22646308266188128 0.07548754351504115 6.626860788274545e-11 10.17869215261989 -0.5649930098317988 GVSK(ub)EEVIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVSKEEVIR 9 1 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 13364100.0 3188800.0 3821500.0 6353800.0 True False 4367785.534079785 3652653.4939894318 4853163.300618586 1.0 0.8362712558777181 1.1111267397979194 22.058470588467546 -6.745319989227382 1.667138814564241 0.9031922093211425 1.1114866148103135 0.628709220373949 0.06878930570382882 0.3082254978702079 1.6839449793089325 0.03261648737215791 0.0795778376768227 1.797545990840113e-07 6.745319989227382 0.208294405489171 GVSK(ub)EEVIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVSKEEVIR 9 1 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 22519100.0 3187700.0 13084800.0 6246600.0 True False 2650713.7890541125 13014309.585270548 7552735.178984885 1.0 4.909737761584063 2.8493212696795993 21.33794947287384 -10.415881857988284 6.598562521879053 0.9995973001628969 3.8795295156318312 0.7225447351823933 0.8411615104635475 0.004983750007078317 0.00044116855873252745 0.8145343017668376 0.27148371012466627 3.8381164035385695e-11 10.415881857988284 2.8799322154689344 GVSLLLSVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVSLLLSVLR 10 0 Q14674;Q14674-2 Q14674 ESPL1 Separin 0 9853400.0 1961900.0 3814500.0 4077000.0 False True 2976345.7341022305 3133772.6721754703 3271179.1629874227 1.0 1.052892691957618 1.099058864535482 21.505110689823823 -6.972720035331434 0.18183918037876826 0.9651693082340443 1.1880329540611598 0.9999965408759585 7.505039939631231e-05 0.07542947068933151 0.005746518094448455 0.001749194568703085 0.00515220390320369 1.0648292311678182e-07 6.972720035331434 0.2228636458271155 GVSSLSIQFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVSSLSIQFAK 11 0 Q5VZK9-2;Q5VZK9;Q5VZK9-3 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 0 10507500.0 3528300.0 1604200.0 5375000.0 False True 3416296.047793774 2244765.4257924827 3967126.2534563974 1.0 0.6570757903847766 1.1612360866729763 21.704001570095635 -6.723567947274191 1.7465568756877679 0.792164338714249 1.1606071087603573 0.5292309097842929 0.1442446294483641 0.34844739189262547 2.0791630975291957 0.06552928800510231 0.16381175155549738 1.8898705295323659e-07 6.723567947274191 0.36844277004610837 GVSSLSIQFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVSSLSIQFAK 11 0 Q5VZK9-2;Q5VZK9;Q5VZK9-3 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 0 13511300.0 4175900.0 4834300.0 4501100.0 False True 6335145.599183197 3971581.3944417024 3611455.6120977863 1.0 0.6269124098669123 0.5700667104736186 22.59494634619708 -13.999999999999998 0.26489164427541334 3.8022665349736218 0.5502432631752481 0.9995724668493285 0.0039428951224268075 14.638935562517155 0.1628891018044959 22.0234948368137 0.024227915201318586 1.0000000000000041e-14 13.999999999999998 -3.2520232717983735 GVSSQETAGIGASAHLVNFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVSSQETAGIGASAHLVNFK 20 0 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 31553900.0 6725900.0 13564000.0 11264000.0 False True 8817720.03370825 11540304.072057897 10098509.331917569 1.0 1.3087628126025541 1.1452517536634341 23.071974240835246 -10.156535692274215 4.078184823501182 0.9999227098046368 1.2270072830328396 0.7198837418952824 0.06675311049919733 47095412.71378351 57513629.88436885 45272.304208264984 0.024429134502376215 6.973716813846116e-11 10.156535692274215 0.22708457322820275 GVSSQETAGIGASAHLVNFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVSSQETAGIGASAHLVNFK 20 0 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 29302900.0 5565800.0 4165100.0 19572000.0 False True 5389116.725564893 5828246.150709564 14445506.052585779 1.0 1.0814844894825766 2.6804960419690267 22.361617404441123 -6.917474076024579 0.8432443115987146 0.9614056642132386 2.9239462116701325 0.9934500981672231 0.06261690226548491 0.09968100976462371 0.11348247052642171 0.05324130464782486 0.155828359355369 1.2092773651660172e-07 6.917474076024579 1.9625405474568938 up GVSSQETAGIGASAHLVNFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVSSQETAGIGASAHLVNFK 20 0 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 58464700.0 6501700.0 40931000.0 11032000.0 False True 9863554.237938983 33626543.254637375 8851520.364502633 1.0 3.4091710192353273 0.8973966331990467 23.23367617104725 -6.655651031482629 1.9880623670939712 2.5563104768189056 0.9078954852008388 0.21724189202796973 1.0268549540421223 0.4949437581696802 3.7556915351819167 0.4179433924552914 1.1380294947145577 2.2097796434140357e-07 6.655651031482629 -1.6484149916180666 GVSSQETAGIGASAHLVNFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVSSQETAGIGASAHLVNFK 20 0 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 27647600.0 6725900.0 9384700.0 11537000.0 False True 9212646.990613153 8970052.922947166 8812198.211973418 1.0 0.9736672784799887 0.9565327121458408 23.135184302358137 GVSSQETAGIGASAHLVNFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVSSQETAGIGASAHLVNFK 20 0 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 10612600.0 5565800.0 5046800.0 0.0 False True 4628209.306746999 5019611.886688629 0.0 1.0 1.0845689021391154 0.0 22.1420226798754 -6.96851017771848 1.1721323622592077 1.0526123525143376 6.789821680954555e-21 0.9771699213203219 0.07442232586834494 0.10066847123162345 0.27345435256622164 0.05310021771974084 0.0994543160079236 1.0752014026850206e-07 6.96851017771848 -1.0526123525143376 down GVSSQETAGIGASAHLVNFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVSSQETAGIGASAHLVNFK 20 0 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 27344900.0 6501700.0 13428000.0 7415200.0 False True 8416578.81766727 12680719.995839346 6065709.686377124 1.0 1.5066359230452642 0.7206859007420654 23.0048024931397 -6.732657749423169 1.7136462072704748 1.3039822413584297 0.7209285731869904 0.571535776675133 0.21293588568192495 0.3312579457258676 1.9069349938294875 0.09842508862487435 0.24349378722843165 1.8507265299822842e-07 6.732657749423169 -0.5830536681714392 GVSSQETAGIGASAHLVNFK(ub)GTDTVAGLALIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVSSQETAGIGASAHLVNFKGTDTVAGLALIK 32 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 54468000.0 12928000.0 10494000.0 31046000.0 True False 19612721.163399585 8621263.71000376 24909744.492054794 1.0 0.4395750920118311 1.2700809991904787 24.225286380087677 -6.724949875268682 1.74175150191826 0.6608547679935963 1.2691394231933784 0.5356644364569771 0.2356970532183386 0.3457833667359033 2.0526589639278714 0.10734598094765896 0.2678973121756337 1.8838665061444287e-07 6.724949875268682 0.608284655199782 GVSSQETAGIGASAHLVNFK(ub)GTDTVAGLALIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVSSQETAGIGASAHLVNFKGTDTVAGLALIK 32 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 50203000.0 12928000.0 10726000.0 26549000.0 True False 16735550.848978326 10129088.671088234 21717354.41574421 1.0 0.6052438167403731 1.297677896098055 23.996412702180127 -6.752062542524003 1.6420703359505253 0.7684539755392946 1.2992841234055945 0.6578236218625886 0.1658998159186351 0.2964776103405785 1.5734461982889896 0.07978667640299808 0.19329362059097036 1.7698540641947137e-07 6.752062542524003 0.5308301478662999 GVTCLSFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVTCLSFSK 9 0 Q2TAY7;Q2TAY7-2 Q2TAY7 SMU1 WD40 repeat-containing protein SMU1;WD40 repeat-containing protein SMU1, N-terminally processed 0 8980500.0 2068000.0 3060100.0 3852400.0 False True 2711168.026540486 2603545.008176373 3453790.6028301828 1.0 0.9603038183872938 1.2739124130337656 21.370483097307893 -6.875136663972216 1.1065119259981782 0.9766730634372848 1.2941691057947566 0.969548736363069 0.02433007872884879 0.13202775307147355 0.29903186143721927 0.017004981161086147 0.040661553345199095 1.3331018650903062e-07 6.875136663972216 0.31749604235747186 GVTFLFPIQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVTFLFPIQAK 11 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 76156000.0 21325000.0 26908000.0 27923000.0 False True 27957281.51159378 22893431.28656248 25033795.8163294 1.0 0.8188718662459602 0.8954302586947869 24.736720748085975 -10.152359824355374 5.280621488559936 1.0000047732046826 0.8571510624756764 0.822758559992459 0.0312548328381462 1.7564148856137056e-06 2.8195397357472527e-07 0.03026337293649506 0.010087453922516846 7.04109454102306e-11 10.152359824355374 -0.1428537107290062 GVTFLFPIQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVTFLFPIQAK 11 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 52461100.0 19666000.0 8950100.0 23845000.0 False True 19041713.59462416 12523921.604154905 17599279.165333513 1.0 0.6577097981187285 0.924248706812927 24.18265997916121 -9.83094552126117 5.915951027885248 1.0000000253583123 0.790979252465474 0.4505394443559141 0.10881405381776721 3.633096754117506e-08 7.297917923355961e-09 0.1053587679115456 0.03511958485561035 1.4758916603654784e-10 9.83094552126117 -0.20902077289283838 GVTFLFPIQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVTFLFPIQAK 11 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 62280000.0 21325000.0 18907000.0 22048000.0 False True 29209428.78645619 18071626.222912002 16840716.49281355 1.0 0.6186915312527934 0.5765506958705828 24.799930809608867 -13.999999999999998 0.3109956391387412 4.707398852917255 0.5673174875571956 0.9996741821432993 0.0034379118544009997 17.340921752024745 0.17747670017345277 41.625370858746784 0.014543955004270288 1.0000000000000041e-14 13.999999999999998 -4.140081365360059 GVTFLFPIQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVTFLFPIQAK 11 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 42232100.0 19666000.0 8374100.0 14192000.0 False True 16353150.35151936 8328987.061171287 17159481.583606046 1.0 0.5093200320510382 1.0493073942790339 23.963065254595485 -6.667487249267287 1.9460751417702715 0.6861303091863374 1.0471120053246423 0.2680382059419255 0.2085510195595712 0.46692114297589365 3.4066490933554823 0.08634412359273544 0.23146569167223346 2.1503678124535116e-07 6.667487249267287 0.3609816961383049 GVTFNVTTVDTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVTFNVTTVDTK 12 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 232078000.0 83499000.0 84581000.0 63998000.0 False True 109467997.60546628 71961844.49415573 57376100.87216443 1.0 0.6573779192848077 0.5241358399461521 26.705933926240718 -13.999999999955822 0.13065095904257046 2.628385644267305 0.33907296203392173 0.9996426789770577 0.0037889227924511304 11.935831873452369 0.1124688209688292 4.988272466006693 0.1646235302410253 1.0000000001017236e-14 13.999999999955822 -2.2893126822333834 GVTFNVTTVDTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVTFNVTTVDTK 12 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 151883000.0 46451000.0 21652000.0 83780000.0 False True 44976438.43099185 30297756.51368836 61835504.653874785 1.0 0.6736361875379427 1.3748421798393418 25.422666086523726 -6.7801314354894435 1.5352073588404072 0.8152359781230302 1.3804341569552032 0.7678973572510996 0.13802435622781487 0.25037448213908664 1.1655431044401892 0.0708089977367569 0.16707171440970994 1.6590847237292806e-07 6.7801314354894435 0.565198178832173 GVTFNVTTVDTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVTFNVTTVDTK 12 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 285816000.0 61764000.0 151710000.0 72342000.0 False True 93700503.5532342 124636165.18435968 58043571.991375014 1.0 1.3301546999003049 0.6194584851766419 26.481553465263573 -6.780386328299346 1.5344176365585653 1.1868461812771767 0.6137639663803038 0.7687507947209586 0.13964070319595226 0.24996682647994584 1.1624965880915232 0.07167720624245426 0.16906986678570604 1.6581112720515332e-07 6.780386328299346 -0.5730822148968728 GVTFNVTTVDTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVTFNVTTVDTK 12 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 195757000.0 83499000.0 46730000.0 65528000.0 False True 114370836.77562976 44665314.0845548 50051635.991522394 1.0 0.39053062252380166 0.43762586164961453 26.76914398776361 -9.983725982766071 7.386073982742616 1.0000000182626385 0.4140782444779557 0.9951778936505513 0.019226550862100584 5.793227136545793e-09 7.887017283680854e-10 0.018616028239580053 0.006205342607827081 1.0381832488559856e-10 9.983725982766071 -0.5859217737846828 GVTFNVTTVDTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVTFNVTTVDTK 12 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 98212000.0 46451000.0 22486000.0 29275000.0 False True 38626064.62821238 22364863.45487847 35396267.14769355 1.0 0.5790096317123447 0.9163829525061222 25.203071361958003 -9.900871805584098 6.531246302047081 1.0000000167204006 0.7476962921092225 0.4271641063867063 0.13773208146221574 3.3518451716765306e-08 5.7809398502217535e-09 0.13335852238417223 0.044452838145131235 1.256400771524215e-10 9.900871805584098 -0.2523037246111781 GVTFNVTTVDTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVTFNVTTVDTK 12 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 236419000.0 61764000.0 117460000.0 57195000.0 False True 79954715.55045617 110923247.74436165 46786096.87025841 1.0 1.3873259004262546 0.5851574425367521 26.252679787356023 -6.775409581761533 1.5536305323661992 1.2206278959565078 0.5796834810551242 0.7508118650078095 0.16350791858445476 0.25779670311085395 1.228692575146817 0.08291725906498074 0.19642411019838635 1.6772214896831812e-07 6.775409581761533 -0.6409444149013835 GVTFNVTTVDTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVTFNVTTVDTKR 13 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 18998800.0 2745000.0 12489500.0 3764300.0 True False 2657861.477537032 17476622.481882084 2778316.9034206336 1.0 6.575445195163893 1.0453204303164905 21.341834485496552 -6.644286400760654 2.0286785044724387 4.63414935297929 1.0683651004827357 0.17123600349660373 2.3830375535179247 0.5227356941536495 4.11667178781869 0.9547898702622412 2.639477616557553 2.2683684554543218e-07 6.644286400760654 -3.565784252496554 GVTFNVTTVDTK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVTFNVTTVDTKR 13 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 25147400.0 4633700.0 7363700.0 13150000.0 True False 7029661.668846273 6049590.202149304 10550896.736150254 1.0 0.8605805637787087 1.5009110300299695 22.745023824706823 -6.849668249778714 1.2365733333997047 0.9256151939249718 1.5263611100428103 0.9398302813424272 0.06744366898852835 0.15782922274891384 0.46456596028859337 0.04267965347951814 0.09874957842619568 1.413616970426252e-07 6.849668249778714 0.6007459161178385 GVTFNVTTVDTK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVTFNVTTVDTKR 13 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 18080200.0 10163100.0 2588000.0 5329100.0 True False 13920672.717450531 2473653.602628457 4070476.3362596394 1.0 0.17769641258267355 0.2924051458488076 23.730725595418225 -10.777381061143464 7.192250218772486 1.0191646765931666 0.23505077921574064 0.9834146102874458 0.04682964425717449 0.013400794045898154 0.00041478901845666853 0.042222895108645644 0.015114202693071212 1.6696249995226226e-11 10.777381061143464 -0.784113897377426 GVTFNVTTVDTKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVTFNVTTVDTKR 13 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 26997200.0 5472500.0 16486100.0 5038600.0 False True 8302182.593340375 13544026.648512771 4042718.5015031677 1.0 1.6313814465339704 0.486946469323145 22.985059231404193 -6.756934810873392 1.6240719779896549 1.3681322683907662 0.48339164762960113 0.6783316088227065 0.2654557330310728 0.28808316215171187 1.4968710355897854 0.12901105643901575 0.310971664089857 1.75010936647054e-07 6.756934810873392 -0.884740620761165 GVTFNVTTVDTKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVTFNVTTVDTKR 13 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 43003600.0 5472500.0 24636100.0 12895000.0 False True 7084259.12910226 23265079.378127612 10548242.313873282 1.0 3.2840525669867526 1.4889690116699597 22.756185553496643 -6.58574379948429 2.2453238748288062 2.5499908996968847 1.4939035843893889 0.0 0.9908305406243003 0.682115671840551 6.476803017175771 0.36932246466677576 1.105477097827597 2.5957101809459635e-07 6.58574379948429 -1.0560873153074959 GVTIASGGVLPNIHPELLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVTIASGGVLPNIHPELLAK 20 0 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 0 22748300.0 4242900.0 12931000.0 5574400.0 False True 5562482.988302049 11001745.204643207 4997614.561420563 1.0 1.9778478833607174 0.8984503093188042 22.407297588114428 -6.668150235029094 1.9437863046771269 1.6251434194179304 0.9028355141558579 0.2709196259070634 0.41554598989398656 0.46539239582009306 3.3881781559884483 0.17220949456837958 0.4612374248958208 2.1470876059118908e-07 6.668150235029094 -0.7223079052620724 GVTIASGGVLPNIHPELLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVTIASGGVLPNIHPELLAK 20 0 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 0 21230700.0 11077000.0 4706900.0 5446800.0 False True 10725366.698243236 6586389.716159242 4020119.6795025663 1.0 0.6140945947552601 0.3748235181703431 23.35452363824807 -8.712067287553527 0.16245880527230133 1.424459097918569 3.1425181839235056e-11 0.9998360803038401 0.0032975229136469474 0.266563921566526 0.04561903273623521 0.2050023722895642 0.15067426972064402 1.9405851891169567e-09 8.712067287553527 -1.4244590978871439 down GVTIASGGVLPNIHPELLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVTIASGGVLPNIHPELLAK 20 0 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 0 51828000.0 11268000.0 26652000.0 13908000.0 False True 17094379.801143788 21895742.366973527 11159077.703907035 1.0 1.2808737504187475 0.6527921944942617 24.027018745710816 -6.785139376808878 1.5158197998986302 1.1579749769535126 0.6469878729426283 0.7851756356042552 0.11906608061496113 0.24266200800106724 1.1015275729420932 0.0618478174879213 0.14532250539478114 1.6400633481835375e-07 6.785139376808878 -0.5109871040108843 GVTIASGGVLPNIHPELLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVTIASGGVLPNIHPELLAK 20 0 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 0 31188200.0 4242900.0 9153300.0 17792000.0 False True 5811614.790061192 8748876.94008464 13589896.037742116 1.0 1.5054123950277374 2.338402755286371 22.47050764963732 -6.963645189502445 0.38059393423999627 0.9431623093102905 2.930137038872757 0.9998824280092061 0.005983512504173587 0.0784238256912665 0.01650022567882 0.010834018440776815 0.0703669027290814 1.087313575774103e-07 6.963645189502445 1.9869747295624662 GVTIASGGVLPNIHPELLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVTIASGGVLPNIHPELLAK 20 0 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 0 21021100.0 11077000.0 5097900.0 4846200.0 False True 9211016.294303857 5070436.600846072 5859518.013702897 1.0 0.5504752612349256 0.6361424001959974 23.134928913682348 -10.25175151149234 7.090772929634485 1.0000020118914665 0.5933088307154795 0.9677935368754751 0.03497346302978776 1.112345840651555e-06 1.1741918230241174e-07 0.03386307745808189 0.011287636656130726 5.600779673681923e-11 10.25175151149234 -0.4066931811759871 GVTIASGGVLPNIHPELLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVTIASGGVLPNIHPELLAK 20 0 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 0 33792000.0 11268000.0 13046000.0 9478000.0 False True 14586648.125486393 12319978.631644335 7753101.252492514 1.0 0.8446065556430583 0.5315204141344835 23.798145067803265 -6.959900492002154 0.4368352887938853 1.0115712663551364 0.3524128747721651 0.9997664866599725 0.00297728323983436 0.07973670935644114 0.02126292766552854 0.004112215233326998 0.0259572411590535 1.0967294561873294e-07 6.959900492002154 -0.6591583915829713 GVTIASGGVLPNIHPELLAK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVTIASGGVLPNIHPELLAKK 21 1 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 938080000.0 478760000.0 303830000.0 155490000.0 True False 726313922.0443372 249609162.66537488 124757333.34631203 1.0 0.3436656727752187 0.17176778464491052 29.436017993117837 -13.99999999999927 0.1880818963486891 4.495349398477508 0.04603797987155319 0.9994905780061244 0.00805499276757254 12.320114013792463 0.1375266887236448 15.772054106105706 0.12004488800812764 1.000000000001681e-14 13.99999999999927 -4.449311418605955 GVTIASGGVLPNIHPELLAK(ub)KR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVTIASGGVLPNIHPELLAKKR 22 2 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 20313900.0 8901600.0 6410300.0 5002000.0 True False 11670083.803217033 5453908.227153697 4484441.022572054 1.0 0.4673409650794663 0.38426810794073735 23.476311585329764 -13.999999999999998 0.26156833184119016 4.931408931052475 0.354358543701844 0.9995655507455651 0.00568597864873345 14.487001138708349 0.16184895330200802 30.133117304293567 0.03602068540990261 1.0000000000000041e-14 13.999999999999998 -4.577050387350631 GVTIASGGVLPNIHPELLAK(ub)KR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVTIASGGVLPNIHPELLAKKR 22 2 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 191855000.0 81179000.0 53097000.0 57579000.0 True False 123154477.97985902 43621425.5012455 46198485.41222783 1.0 0.35420088832157165 0.37512631428459503 26.875893845253945 -10.728776504242443 10.661010213492352 1.0008156188954935 0.36466360133134706 0.9991870770004017 0.008542769376632429 0.00016575610146983254 4.216952801546621e-06 0.008278799334809876 0.0027571669605156736 1.8673404105984825e-11 10.728776504242443 -0.6361520175641464 GVTIASGGVLPNIHPELLAK(ub)KR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVTIASGGVLPNIHPELLAKKR 22 2 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 219757000.0 81179000.0 111140000.0 27438000.0 True False 105087815.7773216 104954961.30008821 22444565.53765449 1.0 0.9987357765859849 0.21357914208830783 26.647020167346394 -6.9072500257161344 0.9142609161153922 1.0264745212076283 0.11786106298826493 0.989841679664058 0.037334549579751276 0.10626469156516197 0.14884047055261923 0.030156614222241782 0.08174178822168408 1.2380836097904322e-07 6.9072500257161344 -0.9086134582193633 down GVTIASGGVLPNIHPELLAKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVTIASGGVLPNIHPELLAKK 21 1 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 746920000.0 111420000.0 427720000.0 207780000.0 True False 146072698.99281487 363905843.23950166 186280918.7664979 1.0 2.491265279197735 1.275261702227196 27.1221113225369 -6.59562366359787 2.207388927245018 2.0057474544473073 1.2790380834551014 0.008117995026044156 0.6452935222625376 0.6532649531406509 6.009098564497497 0.2432592254620095 0.7183734607440015 2.537326389659427e-07 6.59562366359787 -0.7267093709922059 GVTIASGGVLPNIHPELLAKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVTIASGGVLPNIHPELLAKK 21 1 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 1188290000.0 338070000.0 628730000.0 221490000.0 True False 327338152.90016234 879785167.783637 163475124.4424291 1.0 2.6876951555719515 0.4994074873156896 28.2862065246101 -6.700743060900578 1.8279512402725948 2.0472658343281194 0.5057932400353112 0.42105178421626055 0.7123092539009588 0.39407493384870257 2.5604308275684837 0.3107933586673902 0.7986258624763073 1.9918514178452406e-07 6.700743060900578 -1.541472594292808 GVTIASGGVLPNIHPELLAKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVTIASGGVLPNIHPELLAKK 21 1 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 1024840000.0 528070000.0 318070000.0 178700000.0 True False 801120797.0882131 261307923.40774694 143379866.6730075 1.0 0.32617793016672086 0.178974091290779 29.577444555066897 -13.999999999999998 0.2137679194775299 4.95857632234403 0.09537322768971293 0.9994924596504045 0.008052355461082884 12.837539310227639 0.1465179888442661 21.38354676903835 0.08495023974707722 1.0000000000000041e-14 13.999999999999998 -4.863203094654317 GVTIASGGVLPNIHPELLAKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVTIASGGVLPNIHPELLAKK 21 1 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 655680000.0 111420000.0 178580000.0 365680000.0 True False 152614985.01228353 170689745.11491117 279313915.41600406 1.0 1.1184337180334738 1.8301866975482315 27.18532138405979 -6.935800707993419 0.6975367592774465 0.9911430828706825 2.0005239589298522 0.997560514051442 0.018108807138648802 0.0897355904647208 0.06373164150609692 0.017110153930984456 0.062475788037435795 1.1593092258167187e-07 6.935800707993419 1.0093808760591698 GVTIASGGVLPNIHPELLAKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVTIASGGVLPNIHPELLAKK 21 1 O75367-2;O75367-3;O75367;D6RCF2 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 976934000.0 528070000.0 292350000.0 156514000.0 True False 683597024.8159022 276080465.50369596 128030057.96925654 1.0 0.40386434621778305 0.18728878757735376 29.348570877159347 -11.507874534872617 0.18404551475139846 2.239433973299477 2.997754238680457e-22 0.9994491500606809 0.008065242390505713 4.15476810506604 0.11191755524716882 2.2075464975387518 0.15188279839237037 3.1054566067412898e-12 11.507874534872617 -2.239433973299477 GVTIIGPATVGGIKPGCFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVTIIGPATVGGIKPGCFK 19 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 138160700.0 45079900.0 39686300.0 53394500.0 False True 59100185.45437255 33765258.73598575 47869749.33621021 1.0 0.57132238209394 0.8099762964900908 25.816659321749434 -10.129639862737923 5.303684297842561 1.0000074874796399 0.6906493392918327 0.6913853854664287 0.09743005256537807 8.626124925731762e-06 1.41567843687244e-06 0.09433852487098125 0.0314454142503928 7.419252253170768e-11 10.129639862737923 -0.30935814818780716 GVTIIGPATVGGIKPGCFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVTIIGPATVGGIKPGCFK 19 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 47862200.0 24701300.0 7543900.0 15617000.0 False True 23917170.75230802 10556218.610918796 11526439.200042523 1.0 0.4413656916297307 0.48193155116100916 24.511543402283213 -10.030381378011308 6.448113650428238 1.0000003011998242 0.46164862325460937 0.9957596126555385 0.016560942804859466 7.167967558242429e-08 1.0820353593606877e-08 0.01603507276066527 0.005345021306723597 9.324351183018205e-11 10.030381378011308 -0.5383516779452149 GVTIIGPATVGGIKPGCFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVTIIGPATVGGIKPGCFK 19 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 62959600.0 12016600.0 38064000.0 12879000.0 False True 18230060.731134575 31271181.804610595 10333460.004933776 1.0 1.7153635561511587 0.5668362907472694 24.11981603175209 -6.738265514616461 1.692981228299553 1.4264902408881635 0.5664063918425983 0.5971563069585357 0.3005802252145947 0.32096464211805004 1.8056251494721265 0.14049258874607742 0.3454234913461205 1.8269829120954463e-07 6.738265514616461 -0.8600838490455651 GVTIIGPATVGGIKPGCFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVTIIGPATVGGIKPGCFK 19 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 114205700.0 45079900.0 30681400.0 38444400.0 False True 61747157.26849071 29325794.298178013 29364624.507271394 1.0 0.4749335126581257 0.4755623709053895 25.879869383272325 -9.962012597897841 5.206908136102212 1.0000020195490928 0.47524794177785906 0.9999989223502118 0.00025673031885205353 532975.1883142749 0.12424643285872532 13.20526029462802 9.395367396440955e-05 1.0914086766994226e-10 9.962012597897841 -0.5247540777712338 GVTIIGPATVGGIKPGCFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVTIIGPATVGGIKPGCFK 19 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 45260300.0 24701300.0 5335000.0 15224000.0 False True 20540225.40313154 5306259.296085411 18407268.012177177 1.0 0.25833500810932797 0.896157060154307 24.29194867771749 -10.601676110067666 9.097424455371433 1.0001005463230004 0.5772460341321591 0.3693850522978862 0.26038976236751576 0.0005311436633193731 2.3255612444327705e-05 0.25218014596312616 0.08404043443102462 2.5022107750980033e-11 10.601676110067666 -0.42285451219084125 GVTIIGPATVGGIKPGCFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVTIIGPATVGGIKPGCFK 19 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 39011900.0 12016600.0 17458000.0 9537300.0 False True 15555725.582598487 16486446.95318461 7801609.260961888 1.0 1.0598314341329909 0.5015265420784492 23.89094235384454 -6.880385037817667 1.0776996075399718 1.0372698717991307 0.4616744477387652 0.9739925353863773 0.0403622023825952 0.12728725070808736 0.27025711629501087 0.02884122255716199 0.06981123443480476 1.3170885133539116e-07 6.880385037817667 -0.5755954240603655 GVTIIGPATVGGIKPGCFK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVTIIGPATVGGIKPGCFK 19 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 1 59899000.0 24788000.0 14835000.0 20276000.0 True False 32088554.64452934 14009419.20898694 16585976.04932877 1.0 0.43658617111865944 0.5168813688576794 24.935555472399944 -10.687820897201926 6.759154844983669 1.0040612134001166 0.47673376998838923 0.9826462943695683 0.03278037720941275 0.0020136677579451904 9.300336979280567e-05 0.03185835843634316 0.01057982125120439 2.052008251392954e-11 10.687820897201926 -0.5273274434117273 GVTIK(ub)PTVDDD ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVTIKPTVDDD 11 1 P41091;Q2VIR3 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 4238200.0 1269800.0 1627800.0 1340600.0 True False 1664720.0967606923 1384938.585114702 1201887.571943242 1.0 0.8319348026191278 0.7219757689487523 20.666848194691724 -9.196060076839817 0.0541894897009564 1.7983916134783824 2.8570391403759606e-10 0.9999960983678723 0.00022574962754963584 0.6579745687204688 0.01891820393015708 0.3468850515023214 0.27574195989370576 6.367074377796216e-10 9.196060076839817 -1.7983916131926785 GVTIK(ub)PTVDDD ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVTIKPTVDDD 11 1 P41091;Q2VIR3 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 5424700.0 1415200.0 1462500.0 2547000.0 True False 1370275.2506413164 2046483.8768367448 1879864.2916378477 1.0 1.493483791580523 1.371888086541761 20.38603428940709 -9.982053760306034 4.622769188320642 0.9999926850792483 1.432685938983121 0.9440807521845354 0.049641238836184966 17075534.465620704 0.7019474287648728 1548.5901712894881 0.016993516414206628 1.0421884113232473e-10 9.982053760306034 0.4326932539038727 GVTIK(ub)PTVDDD ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVTIKPTVDDD 11 1 P41091;Q2VIR3 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 24997400.0 2479700.0 3461700.0 19056000.0 True False 3761886.190352875 2843932.588614447 15289573.247458486 1.0 0.7559858126244055 4.0643370037795545 21.843024772492253 -6.889143367480218 1.0274103089526399 0.8185711266959795 4.344183704453361 0.9803452592224557 0.21104404785853575 0.11984203889298314 0.22591641836661208 0.15668402176937207 0.389440269029476 1.290793092049159e-07 6.889143367480218 3.5256125777573812 up GVTIK(ub)PTVDDD ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVTIKPTVDDD 11 1 P41091;Q2VIR3 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 4254700.0 1269800.0 1107400.0 1877500.0 True False 1739279.3750547268 1058471.4063179118 1434073.1683262624 1.0 0.6085689403892384 0.8245214592285607 20.730058256214615 -10.10904666058299 5.186835109126321 1.0000067804068586 0.716545199808518 0.6967079885076994 0.08816224663884938 6.91276907551687e-06 1.1874942449089218e-06 0.08536476927599805 0.028454242749516395 7.779529633120964e-11 10.10904666058299 -0.2834615805983406 GVTIK(ub)PTVDDD ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVTIKPTVDDD 11 1 P41091;Q2VIR3 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 5642700.0 1415200.0 2796700.0 1430800.0 True False 1176801.5039901459 2781633.6219985127 1729973.664728263 1.0 2.3637237142941356 1.470064117748399 20.166439564841365 -10.115457068752796 5.276952629615342 0.9999802926665984 1.9168939160220024 0.5839514182973831 0.36483500254899337 8.459012987940275e-05 1.4178277145641028e-05 0.3532575473065286 0.11774999074844522 7.665543124957169e-11 10.115457068752796 0.916913623355404 GVTIK(ub)PTVDDD ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVTIKPTVDDD 11 1 P41091;Q2VIR3 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 28139200.0 2479700.0 3802500.0 21857000.0 True False 3210020.532194583 3590887.532333857 17879250.271758664 1.0 1.118649396886844 5.569824271352938 21.614151094584702 -6.912617209800623 0.8777298927842192 0.8733276967298135 6.1784537119855205 0.9918721748743246 0.1917424305825331 0.10271245965905787 0.12957026856923046 0.15904254992387204 0.4474094522735732 1.2228770376805792e-07 6.912617209800623 5.305126015255707 up GVTIK(ub)SVILPLPQNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVTIKSVILPLPQNVK 16 1 O75794;X6RA30;X6RF82;X6RKY7 O75794 CDC123 Cell division cycle protein 123 homolog 1 16222000.0 6580900.0 6814800.0 2826300.0 True False 8627623.629526261 5798058.403882339 2533861.5877839667 1.0 0.6720342301488071 0.2936917158871359 23.04053181123058 -7.257088879734844 0.32238201128529326 1.0615748529025362 2.287671381591967e-24 0.9998468310654689 0.00357167027188632 0.09786122800745381 0.020843546586265044 0.011142448191653605 0.045794753083926366 5.53236875958605e-08 7.257088879734844 -1.0615748529025362 down GVTIK(ub)SVILPLPQNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVTIKSVILPLPQNVK 16 1 O75794;X6RA30;X6RF82;X6RKY7 O75794 CDC123 Cell division cycle protein 123 homolog 1 30652000.0 15967000.0 11246000.0 3439000.0 True False 15460136.324893903 15736586.447115267 2538222.7322114483 1.0 1.017881480241298 0.16417854790351386 23.88204970497373 -6.902116269182697 0.9477826066761346 1.0334624112203536 0.07061189232283316 0.9875903317522767 0.04436916473680884 0.1098645980167849 0.1687606345883471 0.03496545109190548 0.0919801464714315 1.2528057292831855e-07 6.902116269182697 -0.9628505188975205 down GVTIK(ub)SVILPLPQNVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVTIKSVILPLPQNVK 16 1 O75794;X6RA30;X6RF82;X6RKY7 O75794 CDC123 Cell division cycle protein 123 homolog 1 48844000.0 23541000.0 13649000.0 11654000.0 True False 35713418.077629134 11213229.30987626 9350581.791870346 1.0 0.31397804840473165 0.26182265084639283 25.08996288292007 -13.961069838282512 0.36564506290368004 9.999546429372462 0.25600054858008475 0.9997823889616556 0.004961883573336108 21.659863783520745 0.19571121535348235 152.3128698326308 0.0147855074747939 1.0937804628370162e-14 13.961069838282512 -9.743545880792377 GVTIK(ub)SVILPLPQNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVTIKSVILPLPQNVK 16 1 O75794;X6RA30;X6RF82;X6RKY7 O75794 CDC123 Cell division cycle protein 123 homolog 1 17258700.0 6580900.0 7187400.0 3490400.0 True False 9014036.5721355 6869836.902446593 2666039.407044467 1.0 0.7621265841856987 0.29576531953351726 23.10374187275347 -6.960432854750453 0.42929248199715425 1.0186641984946507 0.02136446477074105 0.9997859109448437 0.00427983920928334 0.07954689730835614 0.020562895636072286 0.006077159402366152 0.038728805146148196 1.0953858973157828e-07 6.960432854750453 -0.9972997337239097 down GVTIK(ub)SVILPLPQNVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVTIKSVILPLPQNVK 16 1 O75794;X6RA30;X6RF82;X6RKY7 O75794 CDC123 Cell division cycle protein 123 homolog 1 31598200.0 15967000.0 13962000.0 1669200.0 True False 13277267.958034638 13886783.934759988 2018222.0024912031 1.0 1.0459067316146546 0.15200581993751894 23.662454980408008 -6.894796135851545 0.9935604701718962 1.0426550278323252 0.06748493576387148 0.983795301741714 0.05231885226137509 0.11533858078998714 0.19979822651204332 0.03984750747194359 0.10122026337737539 1.27410102222155e-07 6.894796135851545 -0.9751700920684537 down GVTIK(ub)SVILPLPQNVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVTIKSVILPLPQNVK 16 1 O75794;X6RA30;X6RF82;X6RKY7 O75794 CDC123 Cell division cycle protein 123 homolog 1 50835000.0 23541000.0 16428000.0 10866000.0 True False 30474288.562484425 15513767.358627383 8888499.494575173 1.0 0.5090772612071971 0.29167209191283366 24.86108920501252 -11.531148125878476 0.14509119853958063 2.1934471694942945 2.2146642093409245e-20 0.9996523248664005 0.005524315522630609 4.309515592878313 0.09248906872392192 1.8402826759685835 0.21610475848220348 2.9434175439721376e-12 11.531148125878476 -2.1934471694942945 GVTIPYRPK(ub)PSSSPVIFAGGQDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVTIPYRPKPSSSPVIFAGGQDR 23 2 Q15366-3;Q15366-2;Q15366-6;Q15366;H3BSS4 Q15366-3;Q15366-6 PCBP2 Poly(rC)-binding protein 2 1 6923200.0 2414500.0 2767100.0 1741600.0 True False 2007763.730486296 2752193.0830736523 2105760.507751426 1.0 1.3707753762476076 1.0488089189863963 20.937158075210924 -10.386350266877287 6.045087989553134 0.9999590529521041 1.209792147617002 0.3614726482649375 0.1314422557635963 7.255152828794187e-05 7.364869863638081e-06 0.12729321610211272 0.04242280563002864 4.1081825460831614e-11 10.386350266877287 0.20983309466489786 GVTIPYRPK(ub)PSSSPVIFAGGQDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVTIPYRPKPSSSPVIFAGGQDR 23 2 Q15366-3;Q15366-2;Q15366-6;Q15366;H3BSS4 Q15366-3;Q15366-6 PCBP2 Poly(rC)-binding protein 2 1 34430600.0 5484600.0 8295000.0 20651000.0 True False 7099922.817628904 7833375.958108985 16892729.89715371 1.0 1.1033043822193302 2.379283596606085 22.759371910669767 -6.9229810746421885 0.802305941441628 0.9747555523940428 2.599850706344625 0.994969789592442 0.04448853946587431 0.09644924221186423 0.09675629665692906 0.03894953795947482 0.12021582617308225 1.1940401363122435e-07 6.9229810746421885 1.6250951539505822 up GVTIPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVTIPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTK 38 2 Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0 Q15366-4 PCBP2 Poly(rC)-binding protein 2 0 69916000.0 11628000.0 41137000.0 17151000.0 False True 17640526.12066914 33795780.94515197 13761097.332449643 1.0 1.91580345812668 0.7800842921757288 24.072390253472122 -6.692112507088935 1.858597500742181 1.573028342839484 0.7838836476422842 0.38029970040460737 0.3871600394262059 0.4122404557294477 2.7624941484756054 0.16652897908898215 0.43255164890859243 2.03183058252011e-07 6.692112507088935 -0.7891446951971998 GVTIPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVTIPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTK 38 2 Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0 Q15366-4 PCBP2 Poly(rC)-binding protein 2 0 16130800.0 8080700.0 4016600.0 4033500.0 False True 6719460.085707439 3994961.7785673263 4876886.201203136 1.0 0.594536127547624 0.7257854260607141 22.679913885220255 -10.88885496078694 10.96278725244157 1.0205501067892122 0.6601607768041721 0.8993868431537679 0.05358230174255026 0.022492221156663376 0.00022803452932675496 0.04335915411640088 0.017293613525029814 1.2916505678405725e-11 10.88885496078694 -0.36038932998504014 GVTIPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVTIPYRPKPSSSPVIFAGGQAYTIQGQYAIPQPDLTK 38 2 Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0 Q15366-4 PCBP2 Poly(rC)-binding protein 2 0 47298000.0 11628000.0 22905000.0 12765000.0 False True 15052675.222147295 21630316.614886824 10441900.979960643 1.0 1.4369749094872994 0.6936907111765269 23.84351657556457 -6.74740885060676 1.6597180891528607 1.2577460450969848 0.692525284592186 0.6376439520343922 0.1835999192039646 0.304579104468505 1.6499820790258435 0.08742196282283196 0.2127939339186818 1.7889209470684294e-07 6.74740885060676 -0.5652207605047989 GVTIPYRPKPSSSPVIFAGGQDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVTIPYRPKPSSSPVIFAGGQDR 23 2 Q15366-3;Q15366-2;Q15366-6;Q15366;H3BSS4 Q15366-3;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 46822700.0 11543100.0 18104000.0 17175600.0 False True 15133115.883539407 15402953.768839302 15398433.671988944 1.0 1.0178309534782195 1.0175322643724765 23.85120573087486 -10.447529705646692 8.006312389016676 0.99999933293929 1.0176816089231209 0.9997855451761003 0.00012193931679981446 1.4523704866473875e-09 1.0021081469617489e-10 0.00011807169060895227 3.9355745267786e-05 3.5683734085338185e-11 10.447529705646692 0.017682275983830875 GVTIPYRPKPSSSPVIFAGGQDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVTIPYRPKPSSSPVIFAGGQDR 23 2 Q15366-3;Q15366-2;Q15366-6;Q15366;H3BSS4 Q15366-3;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 48512000.0 12229800.0 4196100.0 32086100.0 False True 11841571.693254078 5871624.612372428 23681787.847632956 1.0 0.49584841982735983 1.9998855271149545 23.49735724210235 -6.816338335522287 1.387888692624071 0.7272240416228745 2.0301459442441883 0.8756928805050149 0.2203714598916042 0.1982877765865487 0.7515128469738043 0.12481230166334138 0.2879566385722365 1.526376476936133e-07 6.816338335522287 1.3029219026213137 GVTIPYRPKPSSSPVIFAGGQDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVTIPYRPKPSSSPVIFAGGQDR 23 2 Q15366-3;Q15366-2;Q15366-6;Q15366;H3BSS4 Q15366-3;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 39535800.0 11543100.0 12146600.0 15846100.0 False True 15810896.010548282 11609923.048565239 12103577.540673638 1.0 0.7342988683765707 0.7655212919368202 23.91441579239775 -9.878624189120545 6.532458002638354 1.0000000118237398 0.7499100802877272 0.9884454008172997 0.012746501042665075 2.2060668464933103e-09 3.8006153882539036e-10 0.012341747208812025 0.004113915521713389 1.3224394944048414e-10 9.878624189120545 -0.25008993153601256 GVTIPYRPKPSSSPVIFAGGQDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVTIPYRPKPSSSPVIFAGGQDR 23 2 Q15366-3;Q15366-2;Q15366-6;Q15366;H3BSS4 Q15366-3;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 23167800.0 12229800.0 5812000.0 5126000.0 False True 10169620.57200303 5780689.602408319 6197822.90005387 1.0 0.5684272644667354 0.6094448515725828 23.277762517536626 -9.928637525323582 7.037078478510591 1.0000000118752606 0.5889360586008758 0.9925877225548718 0.016745359814919265 3.1147312164038126e-09 4.806576955117527e-10 0.01621362540555938 0.005404541640785436 1.1785892476428352e-10 9.928637525323582 -0.4110639532743847 GVTLGFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVTLGFR 7 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7;H0Y9V9 P32969 RPL9 60S ribosomal protein L9 0 268678000.0 69202000.0 64506000.0 134970000.0 False True 90724492.1531214 54881956.2424186 121004599.12366055 1.0 0.6049298810049099 1.3337589029369656 26.434988740190338 -6.759493507385649 1.6142491204815532 0.7703705412117879 1.3363640271632888 0.6888901167794026 0.16615696820918227 0.28379845117145963 1.4573914769867968 0.08121542085801638 0.195281119058556 1.7398287079298977e-07 6.759493507385649 0.5659934859515009 GVTLGFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVTLGFR 7 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7;H0Y9V9 P32969 RPL9 60S ribosomal protein L9 0 114896000.0 34951000.0 23493000.0 56452000.0 False True 33841499.63621019 32873877.414376512 41665527.6763014 1.0 0.9714072298144162 1.2311962567911603 25.01229016499169 -6.879608852956052 1.0820196783093543 0.9823704745120156 1.2494667968562008 0.9733667617840484 0.01898201483674104 0.1279752062718064 0.27440721823553776 0.013518979705227717 0.032658999918168 1.3194445604597215e-07 6.879608852956052 0.2670963223441851 GVTLGFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVTLGFR 7 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7;H0Y9V9 P32969 RPL9 60S ribosomal protein L9 0 203190000.0 69202000.0 48943000.0 85045000.0 False True 94787849.51373234 46780536.42714242 64959122.55675462 1.0 0.49352882956127314 0.6853106478309089 26.49819880171323 -10.112276054519468 5.187012937771888 1.0000102038126588 0.5894197386955602 0.8593749510441346 0.07829459945248328 9.238971101496792e-06 1.5811695116258905e-06 0.07581030304349001 0.025269473314520712 7.721895952274441e-11 10.112276054519468 -0.4105904651170986 GVTLGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVTLGFR 7 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7;H0Y9V9 P32969 RPL9 60S ribosomal protein L9 0 93051300.0 34951000.0 31591300.0 26509000.0 False True 29063305.091831256 31421111.3965179 32051909.33623253 1.0 1.081126571710846 1.1028308458022305 24.792695440425966 -13.999999988909757 0.1850603029255618 0.5722745588297642 1.1192000029402034 0.9994928831164701 0.0009965795605848024 12.274409206112207 0.13640656523129624 1.8902471316912146 0.015534261556939315 1.0000000255362295e-14 13.999999988909757 0.5469254441104392 GVTQFGNK(ub)YIQQTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVTQFGNKYIQQTK 14 1 O43809 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 1 7541210.0 2187500.0 4353800.0 999910.0 True False 1819003.172681206 4330345.215238365 1208986.5579385224 1.0 2.3806144377722265 0.664642358021003 20.794716628645322 -6.69252820321002 1.8572695510521078 1.863485301864948 0.6703556257908126 0.3823751801807498 0.5836043948618418 0.41124691100813754 2.7522522180265705 0.2511863274850314 0.6520690441284551 2.0298866941467843e-07 6.69252820321002 -1.1931296760741352 GVTQFGNK(ub)YIQQTKPLTLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVTQFGNKYIQQTKPLTLER 20 2 O43809 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 1 15563600.0 4720700.0 5855100.0 4987800.0 True False 4570843.962480539 8193071.9639431285 3681345.5492074033 1.0 1.7924637181219487 0.8053973356836236 22.12402913899946 -6.69297068720807 1.8556871744673258 1.4954438208328455 0.8086705496966472 0.38434512494176465 0.33495904083267053 0.4103694298366574 2.7420338853351973 0.1442718257037616 0.37431706909832774 2.027819582986136e-07 6.69297068720807 -0.6867732711361983 GVTQFGNK(ub)YIQQTKPLTLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVTQFGNKYIQQTKPLTLER 20 2 O43809 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 1 6429400.0 2457300.0 2552800.0 1419300.0 True False 3365830.2160355793 2440008.855019291 1084090.5714010457 1.0 0.7249352161004838 0.3220871231817315 21.68253097336537 -6.98109328413187 0.34947113176176414 1.0395787715616431 1.1181649436777752e-15 0.9999265558874462 0.002385789641047347 0.0757596520304106 0.014087038715612513 0.005507110094615852 0.033809328836620675 1.0444958430037121e-07 6.98109328413187 -1.039578771561642 down GVTQFGNK(ub)YIQQTKPLTLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVTQFGNKYIQQTKPLTLER 20 2 O43809 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 1 18577600.0 4720700.0 12374000.0 1482900.0 True False 3925471.212469106 12307338.805953307 1792967.533845079 1.0 3.1352513213851947 0.45675218000575 21.904434414433737 -6.694365884197898 1.8507766133912906 2.333186776461928 0.46548299890389044 0.3908726959738832 0.9022844283977937 0.4074186557344836 2.708978593764153 0.3895100215647849 1.0088117385409918 2.0213155442317604e-07 6.694365884197898 -1.8677037775580376 GVTQYYAYVTER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVTQYYAYVTER 12 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 16906200.0 5476000.0 5886700.0 5543500.0 False True 7179089.029659437 5008427.306176877 4969911.797006834 1.0 0.6976410635785733 0.6922761058505216 22.77536935825086 GVTQYYAYVTER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVTQYYAYVTER 12 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 12583000.0 2770400.0 1653700.0 8158900.0 False True 2682455.1684402907 2314031.033931573 6021839.328246577 1.0 0.8626541316166945 2.2448984046760287 21.355122628913858 -6.882462167021439 1.0660091344948417 0.9117635943961592 2.347587674320385 0.9756162920683695 0.09708910773958969 0.1254697854618049 0.2593161495341587 0.06999803043351248 0.17037796344357542 1.3108042263363277e-07 6.882462167021439 1.4358240799242261 up GVTQYYAYVTER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVTQYYAYVTER 12 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 14048900.0 5476000.0 4546900.0 4026000.0 False True 7500625.183335711 4346002.923412415 3075141.71807272 1.0 0.5794187573947858 0.40998472032768996 22.83857941977375 -13.999999999999998 0.12527232718538336 2.99930315911242 0.1578157367694811 0.9996675135258833 0.004522809887009251 11.946626531368247 0.1095715333491144 5.908738484598117 0.2239441399284148 1.0000000000000041e-14 13.999999999999998 -2.8414874223429387 GVTQYYAYVTER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVTQYYAYVTER 12 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 5375400.0 2770400.0 2605000.0 0.0 False True 2303710.3495296054 2590966.3479479854 0.0 1.0 1.1246927585653443 0.0 21.135527904348134 -6.947826472551082 1.2077631551494945 1.069701796805578 6.233091724326423e-19 0.9711319464912157 0.08552652517089382 0.10857637178866515 0.3149750660858538 0.05882835474027194 0.11200509004154563 1.1276479311168927e-07 6.947826472551082 -1.069701796805578 down GVTYLFPIQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVTYLFPIQVK 11 0 A0A087WVC1;Q9BQ39 A0A087WVC1 DDX50 ATP-dependent RNA helicase DDX50 0 3965300.0 1590900.0 1009900.0 1364500.0 False True 2085685.3062975153 859226.8565593683 1223314.6292082316 1.0 0.4119638058363934 0.5865288620073973 20.9920900659675 -10.915109625436621 11.505685777889074 1.0528326217101964 0.4992463339218956 0.9164694027893189 0.07126588575654055 0.03609942262062669 0.0002663455411494716 0.02579105684817339 0.02300096572398348 1.2158790474124704e-11 10.915109625436621 -0.5535862877883009 GVTYLFPIQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVTYLFPIQVK 11 0 A0A087WVC1;Q9BQ39 A0A087WVC1 DDX50 ATP-dependent RNA helicase DDX50 0 4039600.0 1590900.0 1411700.0 1037000.0 False True 2179098.722455949 1349326.4261323782 792081.9576853969 1.0 0.6192130775110649 0.3634906255154344 21.05530012749039 -8.246317303134838 0.18261254804683985 1.3136988980202373 2.4425278799328407e-09 0.9998432296347625 0.003274440320929415 0.08751210996327886 0.038632240817615286 0.1157193873222751 0.12076214434530763 5.671300988471377e-09 8.246317303134838 -1.3136988955777094 down GVVDSDDLPLNVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVVDSDDLPLNVSR 14 0 P14625 P14625 HSP90B1 Endoplasmin 0 56740900.0 1712900.0 30919000.0 24109000.0 False True 2245628.4877471947 26306005.721318033 21614431.949857984 1.0 11.714317780011827 9.625114780914403 21.09868784024259 -9.47652353229912 8.82736687268607 0.999916666909152 10.669716280910427 0.9661740162085848 0.8529135541708607 0.0 0.0 0.8258299971512598 0.27527666571708653 3.3379241809335233e-10 9.47652353229912 9.669799614001274 GVVDSDDLPLNVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVVDSDDLPLNVSR 14 0 P14625 P14625 HSP90B1 Endoplasmin 0 47143000.0 15774000.0 6499000.0 24870000.0 False True 15273263.004251042 9094084.591837268 18355800.915992662 1.0 0.5954251288219218 1.2018257598840307 23.86450497894319 -6.726891281129355 1.7345958514553077 0.7556856756485841 1.201261756307307 0.544747437090561 0.170119718059855 0.34211422385228285 2.0151449386076226 0.07776711356744452 0.19365443826810771 1.875463942543349e-07 6.726891281129355 0.4455760806587228 GVVDSDDLPLNVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVVDSDDLPLNVSR 14 0 P14625 P14625 HSP90B1 Endoplasmin 0 54251900.0 1712900.0 30035000.0 22504000.0 False True 2346205.4193819812 28707954.387536976 17189018.68442834 1.0 12.235908309809888 7.326305933159142 21.16189790176548 -9.055549547386903 12.80984749909089 0.9999997721898836 9.781107121484544 0.8100755496544385 2.0043367771250984 0.0 0.0 1.9406907394990875 0.6468969131663623 8.799347167829804e-10 9.055549547386903 8.78110734929466 GVVDSEDLPLNISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVVDSEDLPLNISR 14 0 P08238;P07900;P07900-2 P08238;P07900 HSP90AB1;HSP90AA1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha 0 307157100.0 9967100.0 164190000.0 133000000.0 False True 13066964.621533716 139693492.00760716 119238435.82608637 1.0 10.690584696112143 9.12518241838562 23.63942071475241 -9.680652569000562 11.011739630014556 1.000000001440199 9.90788354626794 0.9773629415877866 0.6390728037700905 0.0 0.0 0.6187795815039107 0.20625986050130352 2.0861591209892317e-10 9.680652569000562 8.90788354482774 GVVDSEDLPLNISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVVDSEDLPLNISR 14 0 P08238;P07900;P07900-2 P08238;P07900 HSP90AB1;HSP90AA1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha 0 423156000.0 148600000.0 54156000.0 220400000.0 False True 143882774.33952752 75780773.21980919 162670628.14172828 1.0 0.5266841257938594 1.1305775058094591 27.100318641917312 -6.697620713310518 1.8391148655932912 0.7054142723716539 1.1287181793400256 0.4064246397751621 0.19987983716362323 0.40048072236291793 2.6317148189738533 0.08675551398044283 0.22378978547428213 2.006223377369919e-07 6.697620713310518 0.4233039069683717 GVVDSEDLPLNISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVVDSEDLPLNISR 14 0 P08238;P07900;P07900-2 P08238;P07900 HSP90AB1;HSP90AA1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha 0 1471105700.0 8940700.0 1451900000.0 10265000.0 False True 13563695.552723302 1192797101.2535226 8236118.25069068 1.0 87.94042129720572 0.6072178646797364 23.69324697168327 -3.0107549094134374 2.0207697823578503e-10 8.92907588608982 70.9638058480811 0.0 42.299810391384355 0.0 0.25480925412943906 460618782.5006739 460618771.817532 0.0009755400205397374 3.0107549094134374 62.034729961991275 GVVDSEDLPLNISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVVDSEDLPLNISR 14 0 P08238;P07900;P07900-2 P08238;P07900 HSP90AB1;HSP90AA1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha 0 344107100.0 9967100.0 177700000.0 156440000.0 False True 13652206.220749713 169848626.42468172 119492093.98293504 1.0 12.44111198426905 8.75258489732754 23.702630776275303 -9.872237427134184 8.722402333862615 1.0005204661205191 10.596848435834902 0.9002582312894494 1.5058349075553892 3.5211740920386696e-08 0.0 1.458018366227704 0.48600612207590144 1.3420310772872076e-10 9.872237427134184 9.596327969714382 GVVDSEDLPLNISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVVDSEDLPLNISR 14 0 P08238;P07900;P07900-2 P08238;P07900 HSP90AB1;HSP90AA1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha 0 161292300.0 148600000.0 7180500.0 5511800.0 False True 123567484.0961952 7141817.221282344 6664291.896316212 1.0 0.05779689756993482 0.05393240742142304 26.880723917351588 GVVDSEDLPLNISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVVDSEDLPLNISR 14 0 P08238;P07900;P07900-2 P08238;P07900 HSP90AB1;HSP90AA1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha 0 54556700.0 8940700.0 25342000.0 20274000.0 False True 11573912.397544917 23931695.422591664 16584340.02880704 1.0 2.0677273682897503 1.4329069945548358 23.46437329377572 -10.118468470761425 4.812976572453662 0.999964834614474 1.7503171814230682 0.6506709978077372 0.2591643323868754 33346398.875483733 70105168.5937811 9749.233242478622 0.08871885224074853 7.612574033391503e-11 10.118468470761425 0.7503523468085942 GVVFCYWFNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVVFCYWFNR 10 0 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 0 66257000.0 19197000.0 18975000.0 28085000.0 False True 29123252.488689836 15588762.99764833 22533987.439907238 1.0 0.5352686140980409 0.7737455646019766 24.795668149118768 -10.507934690450504 7.588002010849392 1.000063773986948 0.6545070893500178 0.7367376882892367 0.09735780735826702 0.00010505729924372231 6.812726584943291e-06 0.0942835753906855 0.03142209721015317 3.10502648937326e-11 10.507934690450504 -0.34555668463693023 GVVFCYWFNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVVFCYWFNR 10 0 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 0 2945330.0 571130.0 805600.0 1568600.0 False True 782292.1952079114 770005.9282370496 1198128.986331063 1.0 0.9842945295298562 1.5315619837069112 19.577348045960463 -6.900295619161638 0.9594229078261537 0.977430155726736 1.5893476269154192 0.9867117755652292 0.029321624134227387 0.11118786983243915 0.1762074508227834 0.022909160599176324 0.05969291194978928 1.2580687676144224e-07 6.900295619161638 0.6119174711886832 GVVFCYWFNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVVFCYWFNR 10 0 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 0 58660000.0 19197000.0 17743000.0 21720000.0 False True 24850894.929442856 16755586.452649504 17767182.866019987 1.0 0.6742447907901221 0.7149514299772671 24.566794471211217 -10.528387985685168 9.515135475419482 1.0000099407582603 0.6945981104914635 0.9868507839239228 0.016618415858681245 3.504609890037544e-06 1.7370684027695003e-07 0.01609123487119319 0.005363570655085138 2.9621838807215553e-11 10.528387985685168 -0.30541183026679686 GVVFSVTTVDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVVFSVTTVDLK 12 0 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 0 6517600.0 1474000.0 2630900.0 2412700.0 False True 1932428.2742363033 2238379.97516788 2163056.9482526197 1.0 1.1583249971088778 1.1193465636428142 20.881983436088028 -10.087672104135617 4.411754895120132 0.9999868920765395 1.138835780386167 0.944183369024444 0.01591287886240756 11063218.77484833 0.2856496447391363 1473.1273646005545 0.005447401687185494 8.171991304870587e-11 10.087672104135617 0.1388488883096276 GVVFSVTTVDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVVFSVTTVDLK 12 0 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 0 30418100.0 6444100.0 12245000.0 11729000.0 False True 9776170.826814923 10059784.079378325 9410758.008996686 1.0 1.0290106686541813 0.962622091584575 23.22083806405994 -6.787931074708866 1.504523129695025 1.0162580968840242 0.9619551894288415 0.7945501681609821 0.01231735131505403 0.23846253258389138 1.0663756502219663 0.006444701201076321 0.015112107404675222 1.629554632782902e-07 6.787931074708866 -0.054302907455182736 GVVFSVTTVDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVVFSVTTVDLK 12 0 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 0 24247600.0 6444100.0 12617000.0 5186500.0 False True 8342014.482201523 11914852.85876562 4242610.217984 1.0 1.4282944346580897 0.5085834155569989 22.99196438615239 -6.780073095168109 1.535463697883028 1.2424941011290367 0.5012685485616821 0.7676529088865178 0.18112778215504302 0.25048139478403114 1.1664311188350227 0.09290670247503911 0.21921859719928632 1.6593076094471613e-07 6.780073095168109 -0.7412255525673546 GVVLFPWQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVVLFPWQAR 10 0 Q9Y2S7 Q9Y2S7 POLDIP2 Polymerase delta-interacting protein 2 0 8111200.0 2330900.0 2400200.0 3380100.0 False True 3055832.4724677126 2042099.515906323 3030359.676208679 1.0 0.6682629150338344 0.9916642039481754 21.543134023115066 -10.767075061657074 9.683270775037661 1.000944206002615 0.8299635596177456 0.2693190335828889 0.13202802333308958 0.0027050181546533023 6.506740051979535e-05 0.12848868728163815 0.04261186130014503 1.7097197886748013e-11 10.767075061657074 -0.17098064638486943 GVVLFPWQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVVLFPWQAR 10 0 Q9Y2S7 Q9Y2S7 POLDIP2 Polymerase delta-interacting protein 2 0 6887100.0 2148300.0 1143800.0 3595000.0 False True 2080103.3924199676 1600525.3048382038 2653361.652311762 1.0 0.7694450721395015 1.2755912335804003 20.98822380924072 -6.782829902903198 1.5245376403446202 0.8699340934733193 1.2799844632770363 0.7773730531742977 0.09762510202547997 0.24620277766768375 1.1303637676060287 0.05042376995814106 0.11871598515706838 1.6488080422478019e-07 6.782829902903198 0.410050369803717 GVVLFPWQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVVLFPWQAR 10 0 Q9Y2S7 Q9Y2S7 POLDIP2 Polymerase delta-interacting protein 2 0 9701200.0 2330900.0 2788300.0 4582000.0 False True 3192696.7202040213 2665103.6863249317 3499825.9692521584 1.0 0.8347500310504359 1.0961974393322615 21.606344084637957 -6.735900594340101 1.7018527850908207 0.9012126455808771 1.0962135851813413 0.5863533351174299 0.06944082647480423 0.32527604963969725 1.848181324308955 0.03230202587318021 0.07962123779976155 1.8369587567049408e-07 6.735900594340101 0.19500093960046416 GVVLFPWQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVVLFPWQAR 10 0 Q9Y2S7 Q9Y2S7 POLDIP2 Polymerase delta-interacting protein 2 0 5353900.0 2148300.0 1731000.0 1474600.0 False True 1786406.6358267586 1721674.759423403 1782932.0422199464 1.0 0.96376419841645 0.9980549816950248 20.768629084674995 -9.937969529379208 4.159123082216021 1.0000006183975507 0.9809095900677868 0.29241181615891754 0.013999153720137138 9588624.88555175 86.41290568818003 67.0871189047597 0.004792282664090365 1.1535341883216443e-10 9.937969529379208 -0.019091028329763948 GVVLWMAPDGLYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVVLWMAPDGLYAK 14 0 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 0 10307200.0 2740500.0 4049200.0 3517500.0 False True 3592822.0390397557 3445075.14365798 3153542.842242542 1.0 0.9588772018829901 0.877734217831001 21.776686046341606 -6.960308063198703 0.4310716435988548 1.0031867273694026 0.83030748834393 0.9997814382247534 0.000750971240266264 0.0795912710259009 0.02072618552012515 0.0010591896787746152 0.006735717950966361 1.0957006941935757e-07 6.960308063198703 -0.17287923902547264 GVVLWMAPDGLYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVVLWMAPDGLYAK 14 0 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 0 8082600.0 2745100.0 1631000.0 3706500.0 False True 2657958.30309177 2282266.8055526367 2735656.4573834674 1.0 0.8586541041286749 1.029232269822035 21.34188704173564 -6.686703252716452 1.8782099619695158 0.9111114546696527 1.0286188358272332 0.35497615312579 0.05982019734754044 0.42380996437047896 2.89603321204864 0.025504452367879533 0.06669073332543925 2.0572958370176944e-07 6.686703252716452 0.11750738115758053 GVVLWMAPDGLYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVVLWMAPDGLYAK 14 0 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 0 11886900.0 2740500.0 3716000.0 5430400.0 False True 3753736.9092278183 3551814.8328312733 4147851.362598635 1.0 0.9462077174614557 1.1049925615196856 21.839896107864497 -6.815299090428541 1.3919166797278186 0.9708594031423607 1.108125703224262 0.8732338951168018 0.023476503949402282 0.19968490641471617 0.7613903057469735 0.013257321115802183 0.030603376075585442 1.530033393589546e-07 6.815299090428541 0.13726630008190122 GVVLWMAPDGLYAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVVLWMAPDGLYAKR 15 1 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 1 32006800.0 7736700.0 7386100.0 16884000.0 True False 11737139.528532937 6067992.747137295 13546869.99947992 1.0 0.5169907652870642 1.1541883749909878 23.484577514667052 -6.704042402216128 1.8167243517145966 0.7012548754414588 1.152423896965256 0.43660046704461297 0.20373898240830013 0.38720269435214866 2.487295923130181 0.08937980665421119 0.22869817659753233 1.9767766286753149e-07 6.704042402216128 0.45116902152379723 GVVLWMAPDGLYAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVVLWMAPDGLYAKR 15 1 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 1 16010200.0 3992600.0 6871100.0 5146500.0 True False 5468772.115958029 6567512.0823108135 3931002.695494596 1.0 1.2009116384913225 0.7188090145544409 22.382785515491307 -6.79351745165466 1.4822000693246564 1.1117810567647517 0.7131707461373349 0.8125096011812556 0.08561527051768907 0.2301626153852147 0.9987978128065158 0.04545615478102691 0.10616017735843111 1.6087277316036794e-07 6.79351745165466 -0.3986103106274168 GVVLWMAPDGLYAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVVLWMAPDGLYAKR 15 1 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 1 19697700.0 7349000.0 8499600.0 3849100.0 True False 6111019.115901344 8453810.967761498 4653929.013772403 1.0 1.3833717105816323 0.7615634848306266 22.542981563255847 -6.739872821767275 1.6868908282683246 1.2281295661053613 0.7611874593462877 0.6045335563085259 0.161076789426542 0.3180228225072242 1.776810060494643 0.07553752364614526 0.18540760936716416 1.8202338154803418e-07 6.739872821767275 -0.46694210675907355 GVVLWMAPDGLYAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVVLWMAPDGLYAKR 15 1 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 1 24126000.0 7736700.0 7473900.0 8915400.0 True False 10015310.663156778 7057970.894913884 7292888.679729028 1.0 0.7047181193168546 0.7281739853120387 23.2557038367595 -10.722209167784339 6.791494398348573 1.0036814661914712 0.7164460523144491 0.9948941290136525 0.009575817193883375 0.000538927899416853 2.204361491870912e-05 0.009361130230076108 0.003090581709853075 1.8957926370937223e-11 10.722209167784339 -0.2872354138770221 GVVMHTFGGYANSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVVMHTFGGYANSK 14 0 Q6UXN9 Q6UXN9 WDR82 WD repeat-containing protein 82 0 9118380.0 3025000.0 905680.0 5187700.0 False True 2928973.030801282 1267322.747058805 3828885.7423359524 1.0 0.43268501748959515 1.3072451340695619 21.48196347865331 -6.73161978097719 1.7173910130968706 0.6592058812176143 1.3068731035120305 0.5667131640341568 0.2384569906313107 0.3332184580661337 1.9261455766132476 0.11000044059501941 0.2724525298819766 1.855155076165783e-07 6.73161978097719 0.6476672222944162 GVVPLAGTDGETTTQGLDGLSER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVVPLAGTDGETTTQGLDGLSER 23 0 P09972;A8MVZ9;J3KSV6;J3QKP5;K7EKH5;C9J8F3 P09972 ALDOC Fructose-bisphosphate aldolase C;Fructose-bisphosphate aldolase 0 16032200.0 6547300.0 1354300.0 8130600.0 False True 6339459.545310829 1895079.0525811987 6000951.947228381 1.0 0.2989338505966097 0.9466030825399249 22.595928421591836 -10.828055762292673 10.196298540906692 1.006659064307458 0.6227684665682915 0.31144769390506755 0.2644098567269016 0.039760492021290096 0.0006704956729448311 0.254319415904563 0.08533791430636493 1.485744864226485e-11 10.828055762292673 -0.38389059773916645 GVVPLAGTNGETTTQGLDGLSER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVVPLAGTNGETTTQGLDGLSER 23 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 151956300.0 5178300.0 77072000.0 69706000.0 False True 6788801.446728532 65573158.02430298 62493491.787166774 1.0 9.659018390632436 9.205379223055916 22.694725460511233 -10.444559413059759 7.781406766221283 0.999598364899399 9.432198806844177 0.9978339973905651 0.18519741465056438 0.0012904000072700233 9.211107506775445e-05 0.17931582186458436 0.05977220855852542 3.5928624173263e-11 10.444559413059759 8.432600441944778 GVVPLAGTNGETTTQGLDGLSER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVVPLAGTNGETTTQGLDGLSER 23 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 150725000.0 41018000.0 19186000.0 90521000.0 False True 39715906.04211809 26847069.85366828 66810834.5282096 1.0 0.6759777763900788 1.6822185664695088 25.243213580201214 -6.82003450092795 1.3716963330658605 0.8253597747045021 1.7042074529265443 0.8844697558322295 0.14254693084745074 0.19343591054218562 0.7151468628767184 0.08166253352542155 0.1882198873449724 1.5134410139049678e-07 6.82003450092795 0.8788476782220422 GVVPLAGTNGETTTQGLDGLSER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVVPLAGTNGETTTQGLDGLSER 23 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 150677200.0 5178300.0 76971000.0 68527900.0 False True 7092857.448295707 73570166.71094088 52343021.396402165 1.0 10.372429905329415 7.379680443032068 22.757935522034124 -9.323046355660999 9.938153549521445 1.0000148959559576 8.876055174180804 0.9022917016543869 1.221784851800034 0.0 0.0 1.1829880959037276 0.3943293653012424 4.752844923885048e-10 9.323046355660999 7.876040278224846 GVVPLAGTNGETTTQGLDGLSER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVVPLAGTNGETTTQGLDGLSER 23 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 47047400.0 41018000.0 2118700.0 3910700.0 False True 34108284.405502975 2107286.142570978 4728409.288966191 1.0 0.061782237931351125 0.13862934977179084 25.02361885563549 -10.491668271035248 6.069282524985468 1.0007394934180787 0.10020579385157181 0.9945592265322473 0.031372702035945076 0.00031414885455427396 2.6311498061643546e-05 0.030398184450566468 0.01012549604256186 3.223530093581134e-11 10.491668271035248 -0.9005336995665069 GVVQELQQAISK(ub)LEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVVQELQQAISKLEAR 16 1 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-3;E9PL71;E9PN91 E9PI39;P29692;P29692-3 EEF1D Elongation factor 1-delta 1 230944000.0 105980000.0 94185000.0 30779000.0 True False 160779408.175827 77376950.87923624 24695517.15908505 1.0 0.48126157296597 0.15359875645317864 27.260507404266583 -8.385621393772496 0.31602039808681015 1.1480500674306724 2.9257830555333033e-24 0.9986200231826553 0.012944771460077215 0.13065253412290936 0.08256722145035654 0.0994320300485186 0.09373102460976465 4.115083066330754e-09 8.385621393772496 -1.1480500674306724 GVVQELQQAISK(ub)LEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVVQELQQAISKLEAR 16 1 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-3;E9PL71;E9PN91 E9PI39;P29692;P29692-3 EEF1D Elongation factor 1-delta 1 221135000.0 105980000.0 99271000.0 15884000.0 True False 137193199.17811927 93746481.58377782 12993274.98360319 1.0 0.6833172645975392 0.09470786497757731 27.031633726359033 -7.391306158285937 0.5832868826113955 1.002630376998922 6.80610425892947e-26 0.9959152571497061 0.023973413821233268 0.10844024980305826 0.0776492139255896 0.02319223580057195 0.06547063547579415 4.061569056724977e-08 7.391306158285937 -1.002630376998922 down GVVQLFNAVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GVVQLFNAVQK 11 0 Q9Y3B9 Q9Y3B9 RRP15 RRP15-like protein 0 5740100.0 1679100.0 2014800.0 2046200.0 False True 2201316.360427531 1714199.693628886 1834478.852536376 1.0 0.7787157377488263 0.8333553893090091 21.069935065222406 -10.134047898044075 7.0947454101339495 1.0000001393195834 0.8060355635289178 0.9438272813619798 0.02230654434098582 4.9161676673594874e-08 5.987917349946416e-09 0.021598234456003656 0.007199406228672946 7.344328635874485e-11 10.134047898044075 -0.19396457579066562 GVVQLFNAVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GVVQLFNAVQK 11 0 Q9Y3B9 Q9Y3B9 RRP15 RRP15-like protein 0 6092200.0 3135400.0 1237400.0 1719400.0 False True 3035868.4432311854 1731500.2729557548 1269037.55910566 1.0 0.5703475975107986 0.4180146744945829 21.53367784347339 -13.999999999999998 0.14445522728523766 3.061878286991484 0.2392430979069355 0.9995857846560198 0.005015242839570998 11.941190658188559 0.11938556759584501 6.924903264113926 0.1603458252252879 1.0000000000000041e-14 13.999999999999998 -2.8226351890845485 GVVQLFNAVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVVQLFNAVQK 11 0 Q9Y3B9 Q9Y3B9 RRP15 RRP15-like protein 0 7524100.0 1679100.0 3088500.0 2756500.0 False True 2299908.645971328 2952039.8576962855 2105471.471899517 1.0 1.283546571672433 0.9154587403232732 21.133145126745298 -6.700969095199177 1.8275284813345396 1.1759041801016272 0.9165375044154057 0.4221405869263626 0.11966741181960207 0.39350216018817125 2.5557724868782716 0.052227087894955025 0.1341481261781773 1.9908150022010177e-07 6.700969095199177 -0.2593666756862215 GVVTLLSDYEVCK(ub)EGDVLTPEQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GVVTLLSDYEVCKEGDVLTPEQAR 24 1 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 1 16061400.0 4874500.0 3038800.0 8148100.0 True False 4053362.7269643634 3022429.3812454287 9851830.037442248 1.0 0.7456597360851001 2.43053254817401 21.950687854251804 -6.868446588465743 1.1423541848609573 0.8574353780339727 2.5263067489795374 0.9631042624201642 0.14245097925266986 0.13834914222369998 0.33841207972431164 0.09686915031559513 0.22873131384551276 1.3537965765675786e-07 6.868446588465743 1.6688713709455647 up GVVTLLSDYEVCK(ub)EGDVLTPEQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVVTLLSDYEVCKEGDVLTPEQAR 24 1 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 1 76257400.0 6698400.0 12578000.0 56981000.0 True False 8671210.845203927 11878023.2430494 46611042.67443301 1.0 1.3698229065228151 5.375378768492721 23.047802034328193 -6.924925868156147 0.7873204440313096 0.9262967385531187 6.1006664823523264 0.9954435886472315 0.13373110614080694 0.09535968530978904 0.09122227540483117 0.11833879094120828 0.37305570095990515 1.1887051159959398e-07 6.924925868156147 5.1743697437992076 up GVVVVIKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVVVVIKR 8 1 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5 P46779 RPL28 60S ribosomal protein L28 0 9399300.0 2029700.0 2276700.0 5092900.0 False True 3079203.290946174 1870405.0970617093 4086286.0827026283 1.0 0.6074315075465425 1.3270595334571103 21.55412568748904 -6.7585697770073745 1.6177320246741267 0.7715654917384359 1.329514186763896 0.6851173746298906 0.16508430343079447 0.28534268276772046 1.4714376909768143 0.08052604544675036 0.19380046054662825 1.7435332058446668e-07 6.7585697770073745 0.5579486950254601 GVVVVIKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GVVVVIKR 8 1 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5 P46779 RPL28 60S ribosomal protein L28 0 4192190.0 2262300.0 1429100.0 500790.0 False True 3098733.4463587273 1365957.6365982709 382513.71609379945 1.0 0.4408115961711344 0.12344195546838185 21.56324722868338 -8.576539810833978 0.32811910186826243 1.1591391989902435 4.806048605903802e-23 0.9983065729225458 0.014911738866641567 0.21067555207772903 0.09679777764634218 0.12533267207689022 0.09085429590945135 2.6513080422069427e-09 8.576539810833978 -1.1591391989902435 GVVVVIKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVVVVIKR 8 1 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5 P46779 RPL28 60S ribosomal protein L28 0 13428100.0 2029700.0 5016600.0 6381800.0 False True 2627486.6613684488 4737421.80005419 5220377.88279771 1.0 1.8030241103438538 1.9868332576344385 21.32525200958149 -10.926366188720783 0.28393327561396053 7.035157900850082e-10 2.0515102759893544 0.9992082241413022 0.012057216592889379 2.776129780770182 0.14592166125685466 1.9079191688861743 0.07095932853807718 1.1847693522511386e-11 10.926366188720783 2.0515102752858385 GVYLLK(ub)FDNSYSLWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GVYLLKFDNSYSLWR 15 1 Q9H3P7 Q9H3P7 ACBD3 Golgi resident protein GCP60 1 32032000.0 5849000.0 11394000.0 14789000.0 True False 8873360.619177302 9360651.678271674 11865947.667751025 1.0 1.054916178887312 1.3372552043141444 23.08104917107654 -6.9391856390199385 0.6670972153486586 0.9967819431985027 1.4116029175758604 0.9980552741242674 0.006515658423825134 0.08814009580123285 0.056316392248605865 0.00630403704459499 0.02438883450451722 1.1503085848507128e-07 6.9391856390199385 0.41482097437735777 GVYLLK(ub)FDNSYSLWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GVYLLKFDNSYSLWR 15 1 Q9H3P7 Q9H3P7 ACBD3 Golgi resident protein GCP60 1 24039700.0 5849000.0 7810700.0 10380000.0 True False 7571645.80102678 7376027.678842892 8490946.507794075 1.0 0.9741643854817719 1.1214135910375826 22.85217549316899 -6.861615184672532 1.1776496742421954 0.9859197100272895 1.1287637836840143 0.9555679682069658 0.013531983546412411 0.1451411001962238 0.38159157618010403 0.00895660532183884 0.020945424296450462 1.375260011988924e-07 6.861615184672532 0.1428440736567248 GWAAAVTFHPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GWAAAVTFHPR 11 0 O15067;H0YGH1 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 35707600.0 14295800.0 12410000.0 9001800.0 False True 18741932.240724117 10558476.373801118 8070380.087362889 1.0 0.5633611432474787 0.4306055524961753 24.159766362694597 -13.999999999999995 0.16679306645008016 3.184111361599749 0.3094104820916093 0.9995201667670259 0.005328173908059618 12.061915108681651 0.12925854667332756 8.521834664019629 0.11147766461547139 1.0000000000000123e-14 13.999999999999995 -2.8747008795081395 GWAAAVTFHPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GWAAAVTFHPR 11 0 O15067;H0YGH1 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 13256200.0 4738700.0 2466500.0 6051000.0 False True 4588272.5623332355 3451386.312627582 4466061.573891097 1.0 0.7522191120382085 0.9733644880983287 22.129519665265246 -10.293171193902834 7.195071476583125 1.000001126409459 0.8627918001675916 0.3391779794352763 0.09028222172053216 1.6313069584628512e-06 1.6022241720056588e-07 0.08741610299772971 0.029138461765185558 5.091301382364101e-11 10.293171193902834 -0.13720932624186744 GWAAAVTFHPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GWAAAVTFHPR 11 0 O15067;H0YGH1 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 65261600.0 20893400.0 16179200.0 28189000.0 False True 31696815.31214213 13291895.351333424 22617431.794322405 1.0 0.41934482125217437 0.7135553389699161 24.917834559333762 -10.525481615005502 6.405894076419544 1.0003956622339356 0.5664500801110622 0.743283437930363 0.12011094089475614 0.0006793131884987167 5.0320406037420875e-05 0.1163990702571856 0.038765639481891136 2.982073785425674e-11 10.525481615005502 -0.4339455821228734 GWAAAVTFHPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GWAAAVTFHPR 11 0 O15067;H0YGH1 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 26391700.0 14295800.0 4717800.0 7378100.0 False True 19581343.589468688 4509351.996321689 5635544.736739271 1.0 0.23028818097788376 0.2878017389863993 24.22297642421749 -10.448362308920908 9.185955513906745 1.0000063455981578 0.2590449599821422 0.9955015799993883 0.023479811735470698 3.0514057355182273e-06 1.8325357424190734e-07 0.022734424336074935 0.007578076651963623 3.561538890994922e-11 10.448362308920908 -0.7409613856160155 GWAAAVTFHPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GWAAAVTFHPR 11 0 O15067;H0YGH1 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 12258900.0 4738700.0 3083700.0 4436500.0 False True 3940439.010004307 3067087.496033472 5364151.637941671 1.0 0.7783618749704032 1.3613081243797267 21.909924940699522 -6.803683662089603 1.4409403146128053 0.878278597316365 1.370095721866731 0.8426860280310313 0.09529111062403611 0.21554103659144594 0.8831269959766607 0.05201746492767769 0.12070611800100488 1.5715070653670122e-07 6.803683662089603 0.49181712455036586 GWAAAVTFHPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GWAAAVTFHPR 11 0 O15067;H0YGH1 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 78473900.0 20893400.0 34257000.0 23323500.0 False True 27046918.170486096 32350567.835676778 19078862.319319364 1.0 1.196090720272082 0.7053987518673545 24.688960881426212 -6.798238504509519 1.4629678341918602 1.1084328164138146 0.6989055190044161 0.8270162208809169 0.08387526145501667 0.22326994654179178 0.9435645551075934 0.045106074433958726 0.10502054141698743 1.5913345628107328e-07 6.798238504509519 -0.4095272974093985 GWDEALLTMSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GWDEALLTMSK 11 0 Q00688 Q00688 FKBP3 Peptidyl-prolyl cis-trans isomerase FKBP3 0 6011680.0 926580.0 2284000.0 2801100.0 False True 1214755.353013483 1943236.1029622704 2511269.042048498 1.0 1.5996933852908088 2.067304363647142 20.212234359259504 -6.973911555181122 0.13529903751611666 0.3297370909588745 3.3494123994228 0.9999990730798182 0.0004205315761266265 0.07505260766269903 0.00408030489257041 0.027777902425473257 0.0622437329597137 1.0619117953445468e-07 6.973911555181122 3.0196753084639254 GWDEALLTMSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GWDEALLTMSK 11 0 Q00688 Q00688 FKBP3 Peptidyl-prolyl cis-trans isomerase FKBP3 0 3151580.0 926580.0 2225000.0 0.0 False True 1269161.6658829793 2126692.1429089312 0.0 1.0 1.6756668595323134 0.0 20.275444420782396 -6.810561034700412 1.5005612099640337 1.3732734492051804 2.5335215350120882e-20 0.8235148295142581 0.28917521337947383 0.21673034550414805 0.9757078129182202 0.15355511998713445 0.34141216804059343 1.5468171027219196e-07 6.810561034700412 -1.3732734492051804 GWEAFLNAPEANR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GWEAFLNAPEANR 13 0 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 0 9929500.0 2501500.0 3514700.0 3913300.0 False True 3279490.7245604564 2990320.460193293 3508389.2550242394 1.0 0.9118246433199105 1.0697969744965392 21.64504036398566 -6.755249776862703 1.63062385364208 0.9484805679843477 1.0702370625880318 0.6711677836672585 0.03706551662298395 0.29097334807857045 1.5237178745777518 0.017945802283718944 0.04332662077053799 1.7569128656747747e-07 6.755249776862703 0.1217564946036841 GWEAFLNAPEANR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GWEAFLNAPEANR 13 0 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 0 6286200.0 0.0 1353300.0 4932900.0 False True 0.0 1893679.74736627 3640825.506172097 0.0 GWEAFLNAPEANR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GWEAFLNAPEANR 13 0 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 0 9530000.0 2501500.0 3027600.0 4000900.0 False True 3426372.1504956647 2893830.621065655 3055969.821121992 1.0 0.8445756893765987 0.8918966437081011 21.708250425508552 -9.832184695368635 5.523655038277223 1.0000000466860715 0.8682361665411921 0.9117987312936957 0.01931869871303162 1.1098535366770408e-08 2.3716753472989736e-09 0.018705256284231662 0.006235083198239259 1.4716864952019198e-10 9.832184695368635 -0.1317638801448794 GWEEGVAQMSVGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GWEEGVAQMSVGQR 14 0 P62942;Q5W0X3;Q1JUQ5 P62942 FKBP1A;FKBP12-Exip2 Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 55698000.0 14045000.0 17965000.0 23688000.0 False True 18413131.011973478 15284692.027021544 21236992.99134086 1.0 0.830097391751701 1.1533613146797856 24.13423163100672 -6.763899034203945 1.5978389998525828 0.901790968734325 1.1547737215394258 0.7066710237110909 0.0715069961149398 0.2764117644141621 1.3916901124234653 0.03529622898000933 0.08449756093617197 1.7222689255515667e-07 6.763899034203945 0.25298275280510085 GWEEGVAQMSVGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GWEEGVAQMSVGQR 14 0 P62942;Q5W0X3;Q1JUQ5 P62942 FKBP1A;FKBP12-Exip2 Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 52077600.0 12597000.0 4783600.0 34697000.0 False True 12197115.130249197 6693716.426144454 25608814.812311918 1.0 0.548795051507208 2.0995796578816672 23.540036625160166 -6.828858683177544 1.3331161946837833 0.7587149241405386 2.140311898255118 0.9035513210925836 0.20226547992646104 0.18222433897929477 0.6337838608548323 0.11914502938914422 0.2741851803174228 1.483000566142718e-07 6.828858683177544 1.3815969741145793 up GWEEGVAQMSVGQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GWEEGVAQMSVGQR 14 0 P62942;Q5W0X3;Q1JUQ5 P62942 FKBP1A;FKBP12-Exip2 Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 54136000.0 3028500.0 44887000.0 6220500.0 False True 4594455.91300709 36876564.14626822 4991015.44845799 1.0 8.026317989442271 1.0863126217683847 22.131462593388513 -6.643301849794787 2.0323542617208266 5.58323854761586 1.11522913931892 0.16742480701959328 3.0038791248442145 0.5251148494513305 4.149271027048016 1.201895120780789 3.3268002283121074 2.2735167081905622e-07 6.643301849794787 -4.46800940829694 GWEEGVAQMSVGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GWEEGVAQMSVGQR 14 0 P62942;Q5W0X3;Q1JUQ5 P62942 FKBP1A;FKBP12-Exip2 Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 53840000.0 14045000.0 22655000.0 17140000.0 False True 19237816.05185355 21654027.189933438 13091885.009380616 1.0 1.1255969560976797 0.6805286511781166 24.197441692529612 -6.831330600352067 1.3218652314782768 1.0670528852996817 0.6682160439679314 0.9085225692334827 0.05666643448639745 0.17917758580730705 0.611821864538145 0.033653068357826825 0.07744708158922661 1.4745836006224655e-07 6.831330600352067 -0.39883684133175024 GWEEGVAQMSVGQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GWEEGVAQMSVGQR 14 0 P62942;Q5W0X3;Q1JUQ5 P62942 FKBP1A;FKBP12-Exip2 Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 24830400.0 12597000.0 6440200.0 5793200.0 False True 10474963.641721217 6405505.3643203955 7004531.335269616 1.0 0.611506214571248 0.6686926632729249 23.320441900594442 -10.388274177347244 5.871770549990554 1.000092101956008 0.6400994389221408 0.9814161497224942 0.02334626992016039 2.815578288290094e-05 2.9332976704740434e-06 0.02261067811169168 0.007534976216403491 4.090023681925399e-11 10.388274177347244 -0.35999266303386723 GWEEGVAQMSVGQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GWEEGVAQMSVGQR 14 0 P62942;Q5W0X3;Q1JUQ5 P62942 FKBP1A;FKBP12-Exip2 Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 19470000.0 3028500.0 10819000.0 5622500.0 False True 3920452.9506598758 10216913.139334662 4599262.691721792 1.0 2.606054266667067 1.1731457435161061 21.902588915480962 -6.618762277644287 2.121093318905162 2.066576283472206 1.1785563791216052 0.07867790079695558 0.6908747841216807 0.5887666301543751 5.03162042754513 0.26778207213211075 0.7662379539602968 2.4056792506486703e-07 6.618762277644287 -0.888019904350601 GWFDAEGQALDGVSISDLK(ub)SGGVGGSNTNWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GWFDAEGQALDGVSISDLKSGGVGGSNTNWK 31 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 34375400.0 8085200.0 9011200.0 17279000.0 True False 12265839.50729568 7403080.955173055 13863798.076345267 1.0 0.6035527328373836 1.1302771463868517 23.548142643444518 -6.705316792632477 1.8117363359933885 0.7551187764554788 1.1288857915225987 0.44292073864974835 0.1671880209480372 0.3845631329812933 2.457527874026625 0.07351643802735974 0.18784603037447328 1.9709844927642843e-07 6.705316792632477 0.37376701506711996 GWFDAEGQALDGVSISDLK(ub)SGGVGGSNTNWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GWFDAEGQALDGVSISDLKSGGVGGSNTNWK 31 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 38182600.0 8085200.0 7997400.0 22100000.0 True False 10466450.783118792 7552337.6597203985 18078026.76514922 1.0 0.721575805993515 1.727235635054726 23.319268965536967 -6.83285625624597 1.3150911195743915 0.8514990063610129 1.7559126725902356 0.9114717287322522 0.12614631082747363 0.17731019847179766 0.5987124038279712 0.0752909740784699 0.17326746967534992 1.4694125466007077e-07 6.83285625624597 0.9044136662292227 GWK(ub)LQVSYDCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GWKLQVSYDCR 11 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 1 33471900.0 7075300.0 9333600.0 17063000.0 True False 10733747.373716064 7667946.156250342 13690490.571021423 1.0 0.71437736414656 1.275462342680581 23.35565050299357 -6.768349761028708 1.5809754792699642 0.8358238536529573 1.278406482538641 0.7240980385255076 0.12032452168996556 0.2691258912117419 1.3273303560497567 0.06000126527583265 0.14303334248049074 1.7047089409517382e-07 6.768349761028708 0.44258262888568367 GWK(ub)LQVSYDCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GWKLQVSYDCR 11 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 1 18795100.0 7075300.0 5388700.0 6331100.0 True False 9159115.325013652 5088814.107951999 5178904.762571779 1.0 0.5556010517800106 0.5654372260635401 23.12677682508602 -10.624976045950952 6.5098979252248945 1.001590641490165 0.5605191389217754 0.9996244467481878 0.004015601335955512 9.298664884008114e-05 5.3567956096233686e-06 0.003899940032313406 0.0012960297582636606 2.37150450531719e-11 10.624976045950952 -0.44107150256838956 GWLTINNISLMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GWLTINNISLMK 12 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 0 8395900.0 2672700.0 3076500.0 2646700.0 False True 3503935.5824636165 2617498.192103071 2372844.872939118 1.0 0.7470166418592401 0.677194205514124 21.740544821513673 -13.999999999999998 0.18063068222261697 2.3151630652907143 0.6220902554365875 0.9994973897611731 0.003108968122484077 12.212958828967642 0.13473561734005438 5.6380333794068695 0.05185384431738126 1.0000000000000041e-14 13.999999999999998 -1.6930728098541268 GWLTINNISLMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GWLTINNISLMK 12 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 0 8130000.0 2278800.0 2861400.0 2989800.0 False True 2206460.741352056 4003971.94200387 2206681.687922589 1.0 1.8146581386942557 1.0001001361893245 21.073302647587283 -10.287099190666128 4.250223032200365 0.9996198006770181 1.407379137451227 0.2500921996693062 0.3325419120379671 0.0011991404589617363 0.00020113488353595672 0.3222782498853822 0.10732744059885688 5.162984358498619e-11 10.287099190666128 0.40775933677420895 GWLTINNISLMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GWLTINNISLMK 12 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 0 12155700.0 2672700.0 3048200.0 6434800.0 False True 3660869.4170017056 2913520.4449505648 4915032.768865946 1.0 0.7958547855926453 1.3425862026216204 21.803754883036564 -6.805552531856271 1.4328906495376261 0.8881451994880536 1.351232411865702 0.8479775560396637 0.0879517306354367 0.21291702069927396 0.8623424698331236 0.04827313375194065 0.11192042584597633 1.5647590359808925e-07 6.805552531856271 0.4630872123776484 GWLTINNISLMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GWLTINNISLMK 12 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 0 3262130.0 1059200.0 772430.0 1430500.0 False True 880771.7305160825 768268.7662746486 1729610.936115307 1.0 0.8722677393658927 1.9637448344327 19.74840863895812 -6.877727705936995 1.0923487122129962 0.9229723266882599 2.037817547381739 0.9718078821691284 0.08180656118706468 0.12966407588052742 0.2845858865914524 0.057801091757873006 0.13901081151077904 1.3251721315385395e-07 6.877727705936995 1.1148452206934791 GWLYYEAGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GWLYYEAGQR 10 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 GWPLELLCEK(ub)SIGTANRPMGAGEALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GWPLELLCEKSIGTANRPMGAGEALR 26 2 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EQR9 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 139708200.0 47450100.0 48766100.0 43492000.0 True False 71985270.76697302 40063408.443721674 34895787.136779234 1.0 0.5565500833276416 0.4847628794749146 26.10119840458171 -13.999999999999998 0.2562583014304407 4.183923728908213 0.4575693404674601 0.9995547962355265 0.004807751788953851 14.254863202182804 0.1601837203199699 23.450492243923335 0.032015238503492034 1.0000000000000041e-14 13.999999999999998 -3.726354388440753 GWPLELLCEK(ub)SIGTANRPMGAGEALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GWPLELLCEKSIGTANRPMGAGEALR 26 2 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EQR9 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 103570600.0 47450100.0 31458500.0 24662000.0 True False 61425089.83130469 29707806.820756044 20173769.053489134 1.0 0.4836428713795019 0.3284288083077051 25.872324726674158 -13.999999999999709 0.168429435175826 3.5934712957927424 0.1891976882778409 0.9995167633092535 0.0063107309814803446 12.076626865153766 0.12992863352597628 10.231728807080533 0.12837676802936204 1.0000000000006708e-14 13.999999999999709 -3.4042736075149014 GWPLYLSTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GWPLYLSTK 9 0 O75874 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 8891800.0 2426600.0 2666700.0 3798500.0 False True 3181296.0992278303 2268838.754715183 3405467.657784879 1.0 0.7131806295131973 1.070465480598131 21.60118322633428 -6.692970019359869 1.8557093738795858 0.8206874402244462 1.0692821708401228 0.3844345283472126 0.12123195319446856 0.4103143042880609 2.7417352019139365 0.0522162984060037 0.135475676640639 2.02782270132348e-07 6.692970019359869 0.2485947306156766 GWPLYLSTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GWPLYLSTK 9 0 O75874 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 11302300.0 2426600.0 3185400.0 5690300.0 False True 3323779.596399278 3044658.495290839 4346368.335407152 1.0 0.9160229813641023 1.3076584079508962 21.66439328785717 -6.85060920742443 1.2321174458695805 0.955162309965792 1.3235022163558987 0.9411934577915888 0.0408256674976372 0.1567857123934562 0.45771661116591683 0.02592350223874825 0.06001342266303384 1.4105574939347863e-07 6.85060920742443 0.3683399063901067 GWPLYLSTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GWPLYLSTK 9 0 O75874 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 6293000.0 2911000.0 2023800.0 1358200.0 False True 2420625.4791657077 2012897.3877071543 1642193.3403927363 1.0 0.8315608527763324 0.6784169441027013 21.206948451161033 -6.972260261202659 0.19686499629392287 1.09492515284197 0.41083865937937886 0.9999950584258658 0.0002918965318064779 0.07557597076646808 0.006332174876122553 0.005102773094833932 0.016389398312152335 1.0659571298541542e-07 6.972260261202659 -0.684086493462591 GWSFLLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GWSFLLGK 8 0 Q9UIQ6-3;Q9UIQ6-2;Q9UIQ6 Q9UIQ6-3 LNPEP Leucyl-cystinyl aminopeptidase;Leucyl-cystinyl aminopeptidase, pregnancy serum form 0 2800750.0 695210.0 741240.0 1364300.0 False True 911427.0424232165 630649.8813308895 1223135.3232896966 1.0 0.6919367672635397 1.342000254938387 19.797767651000907 -6.777851096962732 1.5443698000922021 0.8250792417668142 1.346795429062092 0.7596679156644265 0.1301616989357026 0.2539288786641748 1.1961230162767538 0.06639385145124348 0.1569371212121087 1.6678189461285603e-07 6.777851096962732 0.5217161872952778 GWVLGPNNYYSFASQQQKPEDTTIPSTELAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GWVLGPNNYYSFASQQQKPEDTTIPSTELAK 31 1 R4GMR5;P48556 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 8363200.0 2603900.0 1311600.0 4447700.0 False True 2521240.6198027995 1835328.7199036437 3282713.9418600965 1.0 0.72794667255805 1.302023264291552 21.26570238067043 -6.777861409124675 1.5444281695691084 0.8455271957313701 1.306251372882075 0.7596688371010316 0.11494668189855986 0.2539144745210676 1.1961620374813826 0.05863176171059703 0.13858275980017967 1.6677793448543266e-07 6.777861409124675 0.4607241771507049 GWVLGPNNYYSFASQQQKPEDTTIPSTELAK(ub)QVIEYAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GWVLGPNNYYSFASQQQKPEDTTIPSTELAKQVIEYAR 38 2 R4GMR5;P48556 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 62417000.0 22850000.0 15668000.0 23899000.0 True False 34665120.55876246 12871922.985357244 19175352.17469617 1.0 0.3713220314216836 0.5531598294080973 25.04698144216868 -10.921074347808002 11.596415737182326 1.0653631642725836 0.4622409304148925 0.921018988778567 0.07423497016966667 0.03479482712727172 0.00023681452826104863 0.019936155324478795 0.023959233597776942 1.1992939758551814e-11 10.921074347808002 -0.6031222338576911 GWVLGPNNYYSFASQQQKPEDTTIPSTELAK(ub)QVIEYAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GWVLGPNNYYSFASQQQKPEDTTIPSTELAKQVIEYAR 38 2 R4GMR5;P48556 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 47613000.0 22850000.0 8093000.0 16670000.0 True False 29579775.440838125 7642617.435681242 13636231.048644226 1.0 0.2583730715254102 0.46099846416744306 24.81810776426113 -10.376005276694018 6.649710179707179 1.0000453951119266 0.35968576784750844 0.9301426281211668 0.08272147015067895 5.5675336997046335e-05 5.2243868791167735e-06 0.08010035888863423 0.026698239688947786 4.207215165714025e-11 10.376005276694018 -0.6403596272644181 GYADIVQLLLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYADIVQLLLAK 12 0 Q92882 Q92882 OSTF1 Osteoclast-stimulating factor 1 0 67520000.0 15636000.0 10463000.0 41421000.0 False True 21417051.747011892 10000710.06348591 31638212.89227275 1.0 0.46695082878908434 1.477244079437167 24.35225655780514 -6.763344016678962 1.599754070724633 0.691662682458417 1.4815728921454283 0.7044941771293636 0.22432391700183926 0.27734770322011576 1.399611742807968 0.1105963652156997 0.26492409565740516 1.7244713493400088e-07 6.763344016678962 0.7899102096870113 GYADIVQLLLAK(ub)GAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYADIVQLLLAKGAR 15 1 Q92882 Q92882 OSTF1 Osteoclast-stimulating factor 1 1 990120.0 990120.0 0.0 0.0 True False 823328.6497531945 0.0 0.0 1.0 0.0 0.0 19.651108903533952 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 GYAFIEFASFEDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYAFIEFASFEDAK 14 0 P19338;H7BY16 P19338 NCL Nucleolin 0 12798300.0 5959800.0 2469000.0 4369500.0 False True 5770609.411229588 3454884.5756649077 3224996.867809804 1.0 0.5987035908099607 0.5588659079115579 22.46029225355594 -13.999999999999934 0.3265393661167783 5.278451752040466 0.5515215861562125 0.9997076134951614 0.0034066521380110267 18.535150279899945 0.18255034217745658 54.36456112061974 0.012933479830998474 1.0000000000001513e-14 13.999999999999934 -4.726930165884253 GYAFIEFASFEDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYAFIEFASFEDAK 14 0 P19338;H7BY16 P19338 NCL Nucleolin 0 110038000.0 21561000.0 46649000.0 41828000.0 False True 32709613.320239685 38324121.47969943 33560677.46613629 1.0 1.171647035521073 1.0260187773412166 24.96321136877836 -10.680485870647175 3.047362927034511 0.9895183830689979 1.0988329063629212 0.38046589425332744 0.05945248859875487 6174270.070838194 5439777.794971507 412839.2281832236 0.020352166747726327 2.0869600200447657e-11 10.680485870647175 0.10931452329392333 GYAFIEFASFEDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYAFIEFASFEDAK 14 0 P19338;H7BY16 P19338 NCL Nucleolin 0 10560300.0 5959800.0 2404100.0 2196400.0 False True 4955837.763906493 2391148.6361235143 2655657.0849938216 1.0 0.4824913062203766 0.5358644111264189 22.240697528990218 -10.82064454487605 11.02443195308495 1.005171685058408 0.5091778590586851 0.991209303064384 0.021789478834640198 0.0027514962309801495 4.476375593392412e-05 0.02095868404735028 0.007032524054091702 1.5113166088575662e-11 10.82064454487605 -0.49599382599972297 GYAFIEFASFEDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYAFIEFASFEDAK 14 0 P19338;H7BY16 P19338 NCL Nucleolin 0 69683000.0 21561000.0 22817000.0 25305000.0 False True 27911139.530849464 21547213.892245002 20699749.651226282 1.0 0.7719933422434946 0.7416304027410769 24.73433769087081 -13.999999999982103 0.2841530669048304 2.9014494476253794 0.7328579057867309 0.9996143992046189 0.0022642672060233368 15.627304570653717 0.16892844682897584 17.31049042697876 0.011778602896933403 1.0000000000412088e-14 13.999999999982103 -2.1685915418386483 GYAFIEYEHER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYAFIEYEHER 11 0 P08621-2;P08621;P08621-3;M0QYR1 P08621-2 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 GYAFITFCGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYAFITFCGK 10 0 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 115877000.0 34925000.0 37018000.0 43934000.0 False True 45787013.21418114 31495058.69503381 39388131.12468623 1.0 0.687860082676875 0.8602467896396211 25.44843512217715 -10.111588607235651 5.009714713292377 1.0000080041986237 0.7740534368747941 0.6961008450573283 0.07037657841867091 6.291826571100264e-06 1.1157567981925994e-06 0.06814424210300972 0.02271394301453258 7.734128665751667e-11 10.111588607235651 -0.22595456732382957 GYAFITFCGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYAFITFCGK 10 0 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 53359000.0 31378000.0 10507000.0 11474000.0 False True 30381922.56544885 14702499.893281162 8468615.187378345 1.0 0.4839226306896472 0.27873862061017446 24.85670983055838 -13.542552736312148 0.13332779083395613 3.181768234684033 2.897942175500571e-20 0.9996435504397736 0.0057288079353456966 10.16529825716244 0.10958023493448935 5.936605920154935 0.2419069879984749 2.867129199384504e-14 13.542552736312148 -3.181768234684033 GYAFITFCGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYAFITFCGK 10 0 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 278704000.0 68139000.0 71585000.0 138980000.0 False True 103371844.62816249 58810097.45384219 111510542.08290195 1.0 0.5689179453591762 1.0787322455550161 26.623268051651156 -6.682587132495309 1.8927413960698474 0.7278864388342107 1.076831311218895 0.3360086003890108 0.1826000547750925 0.43278662689937414 2.9998308794885413 0.07734971279184717 0.20332758705624054 2.076886997963074e-07 6.682587132495309 0.3489448723846843 GYAFITFCGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYAFITFCGK 10 0 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 122398000.0 34925000.0 34594000.0 52879000.0 False True 47837716.31263693 33065522.69294007 40390069.27719003 1.0 0.6912019477862367 0.8443143274905974 25.51164518370004 -10.187013367682493 4.797292319971198 1.0000292284256618 0.7677581376375298 0.7541549556868107 0.06250786726621531 1.9543095259809083e-05 3.311879489441527e-06 0.060530593210838826 0.020174327410315347 6.501096795119799e-11 10.187013367682493 -0.23227109078813202 GYAFITFCGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYAFITFCGK 10 0 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 60629100.0 31378000.0 3814100.0 25437000.0 False True 26092197.28109298 3793552.6862604264 30755759.092600506 1.0 0.14539031134067518 1.1787339625431568 24.637115105992656 -6.68712315803235 1.8770699348747255 0.4627560206925838 1.1749990744835934 0.3567792336629769 0.3616566864082544 0.4228945531771912 2.886700952001615 0.15427983334944137 0.4031543279176286 2.0553076653850042e-07 6.68712315803235 0.7122430537910096 GYAFITFCGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYAFITFCGK 10 0 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 294619000.0 68139000.0 115350000.0 111130000.0 False True 88207278.72049308 108930671.09920081 90905480.29009195 1.0 1.2349397088235203 1.0305893301407563 26.394394373743605 -10.521522825561284 3.420222749029173 0.996935544428896 1.1327645195156946 0.3601216912453691 0.08342569288966804 30247550.955930684 2467.0646468058812 730354.856074925 0.028558819313691718 3.0093809982806274e-11 10.521522825561284 0.1358289750867986 GYAFNHSADFETVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYAFNHSADFETVR 14 0 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 0 23700900.0 8329300.0 8264600.0 7107000.0 False True 11408867.300868904 7899442.644622543 5428472.973259518 1.0 0.6923949973562159 0.4758117374935269 23.443652228797188 -7.868463925698133 0.14232632319287306 1.3581456316796678 3.063010116022168e-14 0.9999686648676777 0.00120390998772039 0.12288445019180165 0.02087899944253275 0.07869401287107419 0.10320761034872764 1.3537425334738905e-08 7.868463925698133 -1.3581456316796372 down GYAFVHFETQEAADK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYAFVHFETQEAADK 15 0 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8;H0YEQ8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 28316500.0 9515300.0 9901400.0 8899800.0 False True 12474650.44629628 8424149.7153549 7978934.068909787 1.0 0.6753014644876104 0.639611835478623 23.57249605440651 -13.999999999999998 0.3117828515579348 4.171593903482635 0.6318581349332328 0.9996759072947734 0.0029187967130901897 17.397748428920885 0.17773199032266718 35.83223056473129 0.012278073326039451 1.0000000000000041e-14 13.999999999999998 -3.539735768549402 GYAFVHFETQEAADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYAFVHFETQEAADK 15 0 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8;H0YEQ8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 20641900.0 3768700.0 5380200.0 11493000.0 False True 3649064.6813820866 7528541.917372351 8482638.517390579 1.0 2.063142907765863 2.324606236954334 21.79909529291912 -10.500678008171404 0.29662127207504657 7.722380283436729e-11 2.4109094562745557 0.9990821532912928 0.017354476696012696 2.073304700231807 0.14390458453138227 1.6502181767294661 0.09504077250607508 3.157344654019909e-11 10.500678008171404 2.4109094561973317 GYAFVHFETQEAADK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYAFVHFETQEAADK 15 0 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8;H0YEQ8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 30021800.0 11287800.0 5911000.0 12823000.0 False True 17124417.848717667 4856135.867146199 10288528.42947944 1.0 0.28357961771587126 0.6008104053738609 24.029551608136163 -10.52533368820904 6.325363244611031 1.0005546838889732 0.4421950115460033 0.8047799992188811 0.129508926743879 0.0010139947657601704 7.609187756690256e-05 0.12551294274592972 0.041798826372019954 2.9830896946211776e-11 10.52533368820904 -0.5583596723429698 GYAFVHFETQEAADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYAFVHFETQEAADK 15 0 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8;H0YEQ8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 26918300.0 9515300.0 4453900.0 12949100.0 False True 13033363.551313784 4257111.970922291 9890789.275085803 1.0 0.3266318747391319 0.7588823281223361 23.635706115929402 -10.408035864775254 7.645128480242392 1.0000136302901186 0.5427571014311631 0.5987119832173304 0.17646550864592284 4.099803012939578e-05 3.1746122587311146e-06 0.17086707632032483 0.05695399801380673 3.9080862082070317e-11 10.408035864775254 -0.4572565288589555 GYAFVHFETQEAADK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYAFVHFETQEAADK 15 0 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8;H0YEQ8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 11693980.0 3768700.0 3884380.0 4040900.0 False True 3133841.0317182466 3863454.073950942 4885833.506989399 1.0 1.2328175024987331 1.5590559500430552 21.579500568353396 -6.9663644326019645 0.33381351280985055 0.9619802777633158 1.8406341265024295 0.999938564650443 0.0017972083769120435 0.07750102058715004 0.013244196489426038 0.004697807192238377 0.02836945633159734 1.0805268606133586e-07 6.9663644326019645 0.8786538487391137 GYAFVQYSNER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYAFVQYSNER 11 0 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2 Q5QPL9 RALY RNA-binding protein Raly 0 73428000.0 14428000.0 20147000.0 38853000.0 False True 18915247.720950752 17141146.132390913 34832864.264292754 1.0 0.9062078586158391 1.8415230283086095 24.17304633478053 -6.8822142904451225 1.067340294969784 0.9399713279437828 1.910697316843766 0.9754294312527948 0.06592146325984828 0.1256881750818771 0.2605695038176384 0.04747707986602965 0.1154889093683364 1.3115525904522272e-07 6.8822142904451225 0.9707259888999832 GYAFVQYSNER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYAFVQYSNER 11 0 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2 Q5QPL9 RALY RNA-binding protein Raly 0 48727900.0 9139100.0 4395800.0 35193000.0 False True 8848984.27299041 6151065.863794169 25974897.532630835 1.0 0.6951154702092707 2.935353565031586 23.077080434868037 -6.872536009443945 1.120548500485733 0.8246053701816093 3.073060696070806 0.9671515250998826 0.17979803333314187 0.13444878675780025 0.31397077203363905 0.12432093465936926 0.2957119013538831 1.3411087330210464e-07 6.872536009443945 2.2484553258891964 up GYAFVQYSNER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYAFVQYSNER 11 0 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2 Q5QPL9 RALY RNA-binding protein Raly 0 91541700.0 6788700.0 31012000.0 53741000.0 False True 10298954.220449487 25477666.302138094 43119067.794482976 1.0 2.4738110061262266 4.186742349904444 23.29599451447738 -6.969149838604054 0.2777409728305237 0.6122207773843168 6.100368828194828 0.9999749716502543 0.006514700033842033 0.07657952328791302 0.010013547015269285 0.032057376296214024 0.15767894352192488 1.0736189325784647e-07 6.969149838604054 5.488148050810511 GYAFVQYSNER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYAFVQYSNER 11 0 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2 Q5QPL9 RALY RNA-binding protein Raly 0 47843800.0 14428000.0 9214800.0 24201000.0 False True 19762421.502039373 8807659.66673134 18485222.23524041 1.0 0.4456771487149203 0.9353723294148361 24.23625639630342 -10.34895936626864 8.465833874560817 1.0000009528490095 0.6905247390648795 0.34748154879682613 0.1999172203691331 3.595436740532722e-06 2.766590667158389e-07 0.19356961039865522 0.06452300542581088 4.477551953676419e-11 10.34895936626864 -0.3094762137841299 GYAFVQYSNER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYAFVQYSNER 11 0 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2 Q5QPL9 RALY RNA-binding protein Raly 0 28358400.0 9139100.0 6013300.0 13206000.0 False True 7599566.580777501 5980905.159353402 15967313.54235494 1.0 0.7870060872262935 2.1010821304918874 22.857485710302313 -6.8653530005528856 1.1584764551095583 0.8823501908722642 2.171513259299719 0.9598166510743925 0.1154358779036954 0.1413838863713054 0.3575793661872039 0.07753435530535344 0.18221366691594842 1.3634744352143284e-07 6.8653530005528856 1.2891630684274549 up GYAFVQYSNER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYAFVQYSNER 11 0 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2 Q5QPL9 RALY RNA-binding protein Raly 0 99329700.0 6788700.0 58095000.0 34446000.0 False True 8788105.975283055 54861962.180390745 28177181.445806775 1.0 6.242751547909469 3.2062860330833938 23.067120836569828 -9.492202928770372 9.310903154019197 1.0000165913798844 4.724518790496437 0.6673378508789178 1.2396318555172485 0.0 0.0 1.200268365059798 0.4000894609816312 3.2195640638042946e-10 9.492202928770372 3.724502199116553 GYAFVTFCTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYAFVTFCTK 10 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 112467000.0 28026000.0 49741000.0 34700000.0 False True 36742357.40417004 42319836.68889944 31109576.865903683 1.0 1.151799712342257 0.8466951786379644 25.130940857514307 -6.771443472528624 1.5691350561705881 1.086907594323916 0.8448927985163935 0.7359904581405528 0.06400068286569546 0.26409506114371795 1.283524129172155 0.03214708096622444 0.07641605219232654 1.6926085388639083e-07 6.771443472528624 -0.2420147958075224 GYAFVTFCTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYAFVTFCTK 10 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 61434000.0 37341000.0 10588000.0 13505000.0 False True 36155630.394430004 14815843.615690568 9967635.358684381 1.0 0.40977970661999685 0.2756869469552924 25.107716994917954 -13.999999999998767 0.2082253960216855 4.38880312662791 0.19533419084977943 0.9994890921666432 0.007111831973358331 12.70573762372794 0.14464558779187311 17.600531138905836 0.08042911695370178 1.0000000000028386e-14 13.999999999998767 -4.193468935778131 GYAFVTFCTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYAFVTFCTK 10 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 473890000.0 126020000.0 106190000.0 241680000.0 False True 191181553.29607174 87239564.83374313 193911842.06789303 1.0 0.45631789955509094 1.0142811308138764 27.510368086538108 -10.836554755511255 12.007215713194462 1.0028855754123926 0.7352995151844838 0.23081656403282913 0.22778753530309223 0.017675128825779714 0.00024059803015474856 0.22154972424394614 0.07351811089187585 1.4569520017723487e-11 10.836554755511255 -0.2675860602279089 GYAFVTFCTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYAFVTFCTK 10 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 113083000.0 28026000.0 35070000.0 49987000.0 False True 38387969.57417209 33520491.439018503 38181100.114580415 1.0 0.8732030323784438 0.9946110861843848 25.1941509190372 -10.573434158239028 7.074007820384859 1.000063478254344 0.9339070592819912 0.2832274079461914 0.04956463041482011 4.966844380547898e-05 2.9950504514238094e-06 0.048036790344833755 0.01599691567979366 2.670335576025478e-11 10.573434158239028 -0.0661564189723528 GYAFVTFCTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYAFVTFCTK 10 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 69758600.0 37341000.0 3516600.0 28901000.0 False True 31050695.98678349 3497655.37780955 34944065.47687418 1.0 0.11264338098245213 1.1253875111768148 24.88812227035223 -6.675174965652073 1.91852148788608 0.4361754390222399 1.1214520790256872 0.3024632316723306 0.3764804014485112 0.4492981067619277 3.192841104718737 0.15768836975258885 0.4185589383982157 2.1126377430217933e-07 6.675174965652073 0.6852766400034473 GYAFVTFCTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYAFVTFCTK 10 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 473090000.0 126020000.0 199150000.0 147920000.0 False True 163135374.22557613 188067127.43308067 121000077.78736998 1.0 1.1528286144305528 0.7417157582270085 27.281494408630557 -6.806023908727001 1.4309882913305716 1.083690432920887 0.7351461848969691 0.8492425135289684 0.06587734183568807 0.21227093352593682 0.8573808474280012 0.03620483932802427 0.08391753643328728 1.5630615907957135e-07 6.806023908727001 -0.3485442480239178 GYALTALMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYALTALMK 9 0 O75843;H0YJ47 O75843 AP1G2 AP-1 complex subunit gamma-like 2 0 8557400.0 3170000.0 2594300.0 2793100.0 False True 4155900.698323672 2207240.552502195 2504096.805307082 1.0 0.5311100319101728 0.6025400958971749 21.98672975201973 -10.654944579436835 6.63820334105752 1.0022187852712556 0.5668250639037111 0.98001385949002 0.029161201510417966 0.0009613731226502979 4.997235219634851e-05 0.028347185454185644 0.009411737317103947 2.2133771418868815e-11 10.654944579436835 -0.4353937213675445 GYAYVEFENPDEAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYAYVEFENPDEAEK 15 0 H3BV80;H3BMS0;H3BMM9;H3BTC0;Q15287-3;Q15287-2;Q15287;H3BPG5 H3BV80 RNPS1 RNA-binding protein with serine-rich domain 1 0 25672100.0 5534500.0 7391600.0 12746000.0 False True 7255783.096174245 6288802.092231132 11427166.188265389 1.0 0.866729615380458 1.5749046018603545 22.790699898019852 -6.858039592225187 1.195662968049285 0.9280388657086828 1.6079249468122327 0.9512033043929696 0.06787803715951984 0.14883817330040117 0.40545367123876475 0.04431265731381821 0.1032172053353412 1.386629411777639e-07 6.858039592225187 0.67988608110355 GYAYVEFENPDEAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYAYVEFENPDEAEK 15 0 H3BV80;H3BMS0;H3BMM9;H3BTC0;Q15287-3;Q15287-2;Q15287;H3BPG5 H3BV80 RNPS1 RNA-binding protein with serine-rich domain 1 0 22260900.0 5665400.0 3279500.0 13316000.0 False True 5485554.978083178 4589021.452366574 9828140.12856285 1.0 0.8365646631382626 1.7916400743096927 22.38720615597363 -6.862827700523068 1.1714489279986604 0.9105785225574052 1.8404319966486427 0.9569810370923503 0.08650586128401956 0.1439124524137566 0.37368825595574434 0.05752851920308022 0.1347378489571049 1.371425749756714e-07 6.862827700523068 0.9298534740912374 GYAYVEFENPDEAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYAYVEFENPDEAEK 15 0 H3BV80;H3BMS0;H3BMM9;H3BTC0;Q15287-3;Q15287-2;Q15287;H3BPG5 H3BV80 RNPS1 RNA-binding protein with serine-rich domain 1 0 32891200.0 2045900.0 26735000.0 4110300.0 False True 3103779.875324818 21963930.3684916 3297897.403391512 1.0 7.076510336027946 1.0625422987016369 21.565594812403866 -6.643767477100577 2.0306945030323384 4.962260422561774 1.0876147804203906 0.1692551617953696 2.597517538490595 0.5239394808733309 4.133788755590704 1.039955912994769 2.8767530455325003 2.2710804714593389e-07 6.643767477100577 -3.874645642141383 GYAYVEFENPDEAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYAYVEFENPDEAEK 15 0 H3BV80;H3BMS0;H3BMM9;H3BTC0;Q15287-3;Q15287-2;Q15287;H3BPG5 H3BV80 RNPS1 RNA-binding protein with serine-rich domain 1 0 20164700.0 5534500.0 7626900.0 7003300.0 False True 7580754.21423877 7289918.339214446 5349264.777490971 1.0 0.9616349683942986 0.7056375429562879 22.853909959542744 -6.933629879318554 0.7163680818419311 1.003417786280671 0.6478697326383084 0.9972048230300126 0.006908086182244324 0.09079638811678169 0.06876415717590441 0.006435461351689683 0.02271878123451283 1.1651185604909142e-07 6.933629879318554 -0.35554805364236264 GYAYVEFENPDEAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYAYVEFENPDEAEK 15 0 H3BV80;H3BMS0;H3BMM9;H3BTC0;Q15287-3;Q15287-2;Q15287;H3BPG5 H3BV80 RNPS1 RNA-binding protein with serine-rich domain 1 0 11372500.0 5665400.0 3878900.0 1828200.0 False True 4711031.119775136 3858003.595798635 2210468.1673582685 1.0 0.818929762447161 0.469211115604725 22.167611431407906 -6.960721704466058 0.42514015832798474 1.014629019074145 0.26020771045432006 0.9997960360460115 0.003146365457991647 0.07944430898617645 0.020186134996827736 0.0045407193361684944 0.029071754179358544 1.0946575972295466e-07 6.960721704466058 -0.7544213086198248 down GYAYVEFENPDEAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYAYVEFENPDEAEK 15 0 H3BV80;H3BMS0;H3BMM9;H3BTC0;Q15287-3;Q15287-2;Q15287;H3BPG5 H3BV80 RNPS1 RNA-binding protein with serine-rich domain 1 0 14236500.0 2045900.0 7729600.0 4461000.0 False True 2648457.880718192 7299440.965135512 3649143.773725369 1.0 2.7561098925825074 1.3778371935957756 21.336721134496315 -6.585294780937714 2.246561718017858 2.1919870740356626 1.3815397653620116 0.0 0.761876320288428 0.6833326830187669 6.494558768430533 0.2838662043650456 0.8503591250062147 2.598395282386734e-07 6.585294780937714 -0.810447308673651 GYCLIINNHNFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYCLIINNHNFAK 13 0 Q14790;Q14790-9;Q14790-7;Q14790-2;Q14790-4;A0A0A0MS31;Q14790-8;C9JB29 Q14790;Q14790-2 CASP8 Caspase-8;Caspase-8 subunit p18;Caspase-8 subunit p10 0 23999300.0 6631700.0 5588600.0 11779000.0 False True 8694222.921474151 4754802.664192177 10560222.07214639 1.0 0.546892195787634 1.2146251789867666 23.051625656380498 -6.72398704155481 1.7452319536446756 0.7255117428226674 1.2138067054439388 0.5311595644956155 0.19058196285842624 0.34762025375619515 2.0713322903403397 0.08664227926274866 0.21646961185374375 1.8880476836767168e-07 6.72398704155481 0.48829496262127137 GYCLIINNHNFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYCLIINNHNFAK 13 0 Q14790;Q14790-9;Q14790-7;Q14790-2;Q14790-4;A0A0A0MS31;Q14790-8;C9JB29 Q14790;Q14790-2 CASP8 Caspase-8;Caspase-8 subunit p18;Caspase-8 subunit p10 0 23521200.0 6631700.0 7585800.0 9303700.0 False True 9083618.70495387 7250634.273113974 7106357.675716138 1.0 0.7982098884401375 0.7823267253435675 23.11483571790339 -13.999999999999998 0.36038943239607396 3.6466828214681684 0.7804249019139593 0.9997739912075795 0.0014895299499247273 21.738700765842236 0.19404418693843528 44.25975421902084 0.004577486756584547 1.0000000000000041e-14 13.999999999999998 -2.866257919554209 GYCNPGIHLCSVGSYTINFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYCNPGIHLCSVGSYTINFR 20 0 C9J6P4;Q7Z2W4;Q7Z2W4-2;Q7Z2W4-4;H7C5K1;Q7Z2W4-5 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 0 18575300.0 4624300.0 4739200.0 9211800.0 False True 7015401.181614225 3893452.732461388 7391083.692324624 1.0 0.5549864692934803 1.0535511086229792 22.74209417725715 -6.6713461585450515 1.93288275021451 0.7162759609477387 1.0515362251175848 0.28493633567324406 0.18897404627742007 0.45801262108052243 3.300300782109408 0.07867806993460286 0.2098182307563262 2.131345426808423e-07 6.6713461585450515 0.3352602641698461 GYDSAGVGFDGGNDK(ub)DWEANACK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYDSAGVGFDGGNDKDWEANACK 23 1 Q06210-2;Q06210;A0A6I8PTT9 Q06210-2 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 1 111649300.0 36198000.0 57600300.0 17851000.0 True False 47455928.54193069 49006559.76421084 16003949.758883212 1.0 1.0326751845327409 0.3372381544434977 25.500084994740625 -6.895877191100034 0.9869757721420929 1.0322743764562703 0.270058691155201 0.9844007670430595 0.040018005760714535 0.11450357183238931 0.19503328325903865 0.030630373426696424 0.0781670440695407 1.270933446344093e-07 6.895877191100034 -0.7622156853010693 down GYDSAGVGFDGGNDK(ub)DWEANACK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYDSAGVGFDGGNDKDWEANACK 23 1 Q06210-2;Q06210;A0A6I8PTT9 Q06210-2 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 1 107264000.0 36198000.0 57844000.0 13222000.0 True False 49581378.814168416 55288260.81547155 10099235.91563772 1.0 1.1151013170225177 0.20369009812110658 25.563295056263517 -6.875222666240535 1.106143243299145 1.0676778566720884 0.14474738517000013 0.9696211436874361 0.07063270056730334 0.13194367864772175 0.29860208990075165 0.04938363983148902 0.11809638626499536 1.3328379003430758e-07 6.875222666240535 -0.9229304715020883 down GYDSAGVGFDGGNDK(ub)DWEANACK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYDSAGVGFDGGNDKDWEANACK 23 1 Q06210-2;Q06210;A0A6I8PTT9 Q06210-2 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 1 44096500.0 21081000.0 17220000.0 5795500.0 True False 17529785.546647985 17127232.442097608 7007312.254635624 1.0 0.9770360508131058 0.3997374774488071 24.063305010983264 -6.915283440457607 0.8589754135366858 1.01502850271988 0.3160423068180864 0.9927673287273383 0.02361805605543065 0.10102723321250047 0.12058174874171126 0.019856483277896013 0.057043512056687014 1.2153925209532975e-07 6.915283440457607 -0.6989861959017936 down GYDVIAQAQSGTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYDVIAQAQSGTGK 14 0 P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9;J3KSN7;J3KT04;J3KS93;E7EMV8;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 103216000.0 24361000.0 28794000.0 50061000.0 False True 31937506.912259594 24498047.438132912 44881167.93902035 1.0 0.7670619846888876 1.4052808837684252 24.928748362505445 -6.807942769120922 1.4232381918150452 0.8727397831912618 1.4159208286795866 0.8543717998801941 0.1006309987517332 0.20961813520378053 0.8372477703167476 0.055603438565080446 0.12874178544641166 1.5561706886626503e-07 6.807942769120922 0.5431810454883248 GYDVIAQAQSGTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYDVIAQAQSGTGK 14 0 P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9;J3KSN7;J3KT04;J3KS93;E7EMV8;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 56066900.0 15425000.0 4871900.0 35770000.0 False True 14935341.818218103 6817275.076622875 26400763.923001874 1.0 0.45645256463478967 1.767670552460893 23.832226920528132 -6.794112270109083 1.479827522003786 0.6978384374323974 1.783250801747466 0.8144176547358265 0.23172458308576852 0.22925409690904633 0.9916451249762578 0.12322672585286368 0.28766852442698315 1.6065258939418475e-07 6.794112270109083 1.0854123643150686 GYDVIAQAQSGTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYDVIAQAQSGTGK 14 0 P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9;J3KSN7;J3KT04;J3KS93;E7EMV8;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 79934000.0 24361000.0 30298000.0 25275000.0 False True 33367920.031271227 28959334.177912254 19305565.55496472 1.0 0.8678795127407581 0.5785666453549467 24.991958424028336 -6.9582338977804215 0.4596473023145998 1.0084627186383401 0.42632756204083844 0.9996989859778618 0.003053441082976258 0.08033813190911238 0.023508683456556732 0.003926845699352818 0.02390107823064513 1.1009462137454501e-07 6.9582338977804215 -0.5821351565975017 GYDVIAQAQSGTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYDVIAQAQSGTGK 14 0 P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9;J3KSN7;J3KT04;J3KS93;E7EMV8;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 30829700.0 15425000.0 8162400.0 7242300.0 False True 12826570.943363454 8118427.531090444 8756631.445388243 1.0 0.6329382628403086 0.6826946565885543 23.61263219596241 -10.061146669314528 4.9882456755057065 1.0000070962359713 0.6578164597125989 0.9843898177679845 0.02031296269467426 1.6031156510513478e-06 3.0170996157876034e-07 0.019668349385393743 0.006555980518005543 8.6866701475501e-11 10.061146669314528 -0.34219063652337234 GYDVIAQAQSGTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYDVIAQAQSGTGK 14 0 P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9;J3KSN7;J3KT04;J3KS93;E7EMV8;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 33731600.0 7632600.0 14508000.0 11591000.0 False True 9880551.161038984 13700617.046443056 9481556.933703385 1.0 1.3866247766083502 0.9596182216120783 23.23616009039722 -6.668265717924136 1.9433763507467845 1.2471467943006813 0.9613517371209838 0.2714304484150383 0.16429551570787654 0.4651235579048018 3.3849046726353276 0.068098567349018 0.18236434980469562 2.1465167514812022e-07 6.668265717924136 -0.28579505717969755 GYEK(ub)GQPDEELKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYEKGQPDEELKPK 14 2 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 1 2724820.0 1002500.0 677120.0 1045200.0 True False 970676.1862407554 947497.5471341533 771430.764672116 1.0 0.9761211416998201 0.7947354386633517 19.888630572946273 -6.931073120742667 0.7379282513750922 1.0026514266123236 0.7564591577442115 0.9967450053317207 0.0052291064522675635 0.09208446681874442 0.07497787602281994 0.004794740495816831 0.016316511239700147 1.1719980234584922e-07 6.931073120742667 -0.24619226886811219 GYEK(ub)GQPDEELKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYEKGQPDEELKPK 14 2 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 1 3378470.0 1002500.0 1863900.0 512070.0 True False 833623.1682801858 1853858.8007448178 619141.4694558296 1.0 2.223857099088835 0.74271144686772 19.66903584838055 -6.687291944866806 1.8765389018178569 1.7692317138252696 0.748056483601288 0.35762382401133164 0.517894401377231 0.42247665236545096 2.882370090123037 0.2209854484794756 0.5773272114836113 2.0545090333841888e-07 6.687291944866806 -1.0211752302239816 GYEVHGIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYEVHGIVR 9 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 18662300.0 6691400.0 4673000.0 7297900.0 False True 8772490.199609783 3975806.6152113364 6542783.31439996 1.0 0.45321300163871236 0.7458296521882688 23.0645550002124 -10.070627685668976 5.266492673333455 1.000005105601437 0.5995213269129156 0.714078645209911 0.11946024735015301 7.161455909278804e-06 1.2636260081990305e-06 0.1156683620612007 0.03855562904312002 8.499087772205701e-11 10.070627685668976 -0.40048377868852136 GYEVHGIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYEVHGIVR 9 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 13102900.0 3481600.0 1455500.0 8165800.0 False True 3371078.5137314848 2036688.7403322277 6026932.011251011 1.0 0.6041653233634698 1.7878349574776684 21.684778797966967 -6.816559034804201 1.3868945666257324 0.7858757379368081 1.811773785980153 0.8762257918832251 0.17308797826841432 0.1980029764738392 0.7492976839490936 0.09809947043867899 0.22631548054185419 1.525601001709615e-07 6.816559034804201 1.025898048043345 GYEVHGIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYEVHGIVR 9 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 14548300.0 6691400.0 3660300.0 4196600.0 False True 9165391.408285718 3498575.843006546 3205449.5116900043 1.0 0.3817159232112832 0.3497340559610151 23.127765061735293 -13.685148803402193 0.4247768109952608 9.999881664949228 0.3488594632434642 0.999865538028747 0.003470436884654549 23.233563426577874 0.21767706145603244 192.53947935244318 0.0076699686766818495 2.064672610674125e-14 13.685148803402193 -9.651022201705764 GYEVHGIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYEVHGIVR 9 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 10168800.0 3481600.0 4307800.0 2379400.0 False True 2895104.661031715 4284593.026368643 2876921.538897422 1.0 1.479944087700706 0.9937193558564431 21.465184073401243 -10.51703111292662 3.08156497867053 0.992311777396133 1.236831721410538 0.24031375130556343 0.19850041733022747 85221871.25809838 105558487.15720339 5553036.041370832 0.06963959315867908 3.04066718398655e-11 10.51703111292662 0.24451994401440502 GYEVHGIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYEVHGIVR 9 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 9170900.0 2843800.0 4114700.0 2212400.0 False True 3681355.1596785765 3885713.3278880045 1809765.9011410025 1.0 1.055511668759303 0.49160317943868675 21.811805510132775 -6.882700449312033 1.0645746935996852 1.0358100646495005 0.4495026048136345 0.9758012197305949 0.039474606350040756 0.12526708544211815 0.25803311813124463 0.028489703463735097 0.06939623705913069 1.3100852308694118e-07 6.882700449312033 -0.586307459835866 down GYFEYIEENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYFEYIEENK 10 0 Q00839;Q00839-2;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PRI6 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 35700900.0 5475900.0 15350000.0 14875000.0 False True 7178957.928691033 13059839.83383136 13335877.69107545 1.0 1.8191832245787531 1.857634189187543 22.77534301222796 -11.129885478320139 0.5239107309901129 9.395530987683565e-21 1.8551116455591106 0.9998470610192168 0.004891596122589733 3.148894162364227 0.2560842724981989 3.7305861719398705 0.007492473598360702 7.415057475576869e-12 11.129885478320139 1.8551116455591106 GYFEYIEENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYFEYIEENK 10 0 Q00839;Q00839-2;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PRI6 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 23496900.0 7933900.0 0.0 15563000.0 False True 7682042.687297296 0.0 11486583.420007788 1.0 0.0 1.4952511835167905 22.873058549931113 -6.726454017965989 1.7359603347006838 0.39584599427369876 1.4938331944510155 0.5428295497544724 0.4205067209074452 0.3429313244944547 2.0228812529458016 0.1920834111478652 0.4786036308248364 1.877353177400288e-07 6.726454017965989 1.0979872001773168 GYFEYIEENK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYFEYIEENK 10 0 Q00839;Q00839-2;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PRI6 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 32619900.0 5475900.0 16147000.0 10997000.0 False True 7500488.2106333105 15433572.14901148 8399735.090324314 1.0 2.057675675982208 1.1198917796332455 22.83855307375085 -6.617187919491049 2.1271882267118007 1.7031497483610083 1.1234087554868302 0.07353073139130173 0.45515694624700054 0.5928559773375119 5.093620066845237 0.17606266896828612 0.5048125510816349 2.4144158891377995e-07 6.617187919491049 -0.5797409928741781 GYFEYIEENK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYFEYIEENK 10 0 Q00839;Q00839-2;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PRI6 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 14245300.0 7933900.0 2929400.0 3382000.0 False True 6597389.381364763 2913618.740759625 4089160.563398788 1.0 0.4416320717691067 0.6198149490689737 22.65346382536539 -10.76925739004639 7.611558588443254 1.0082246590293846 0.5307235104190402 0.9024233443597297 0.07274285504760299 0.010120381114589194 0.0003067966054798722 0.07020840310815449 0.023477655512912195 1.7011500017869067e-11 10.76925739004639 -0.47750114861034443 GYFEYIEENK(ub)YSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYFEYIEENKYSR 13 1 Q00839;Q00839-2;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PRI6 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 14149000.0 3431300.0 5501800.0 5215900.0 True False 4498467.528756462 4680952.885848435 4676208.70244574 1.0 1.0405661163330477 1.0395114942039856 22.101002178498266 -10.094013512918002 4.309875903858008 0.9999950135464647 1.0400388052731013 0.9994798304132121 0.0004305476967104804 2.063176773555477e-08 4.33730971630741e-09 0.000416927927244312 0.00013895866944386938 8.053533825257907e-11 10.094013512918002 0.040043791726636635 GYFEYIEENK(ub)YSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYFEYIEENKYSR 13 1 Q00839;Q00839-2;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PRI6 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 20667200.0 3371700.0 6952300.0 10343200.0 True False 3264667.2290752684 9728389.645765554 7634005.630651198 1.0 2.979902379980444 2.3383717527662276 21.638504513184728 -10.107987024944151 5.2836334217764565 0.9999678772514501 2.659137066374745 0.8991734313696238 0.2619037818453452 9.910514709292034e-05 1.67322612635371e-05 0.2535921152012938 0.0845290821156022 7.798534092083867e-11 10.107987024944151 1.6591691891232951 GYFEYIEENK(ub)YSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYFEYIEENKYSR 13 1 Q00839;Q00839-2;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PRI6 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 79264800.0 23520800.0 16367000.0 39377000.0 True False 35682773.20081136 13446180.974045316 31594118.690447763 1.0 0.37682555944781715 0.8854165709779915 25.08872440748498 -10.137612389788762 7.49545107781927 1.000000126735917 0.6311210652129342 0.412250590805728 0.20763141100248056 4.397100127239068e-07 5.075806410604549e-08 0.20103831814075704 0.06701274974684622 7.284296419596043e-11 10.137612389788762 -0.3688790615229829 GYFEYIEENK(ub)YSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYFEYIEENKYSR 13 1 Q00839;Q00839-2;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PRI6 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 14396300.0 3431300.0 5697700.0 5267300.0 True False 4699944.33739587 5445956.7742257165 4023272.223448688 1.0 1.158727930221232 0.856025504693081 22.164212240021158 -6.764206073991278 1.5964583384968394 1.0917140727694428 0.8546767203382967 0.7079630768786932 0.06680839413726516 0.2759100177236083 1.3867874416070545 0.03300294997242199 0.07899114688750046 1.7210517371644044e-07 6.764206073991278 -0.2370373524311461 GYFEYIEENK(ub)YSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYFEYIEENKYSR 13 1 Q00839;Q00839-2;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PRI6 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 16094400.0 3371700.0 6838000.0 5884700.0 True False 2803717.9416362136 6801162.336763271 7115163.5622214265 1.0 2.425765529322183 2.537760113654339 21.418909788619004 -10.622097955692967 0.4911247724208584 6.409855653897914e-17 2.5343871119546164 0.9996393624259231 0.013293405655113688 2.1072654822699572 0.23478148968330723 2.601877473642989 0.023128086911684966 2.3872727696636983e-11 10.622097955692967 2.5343871119546164 GYFEYIEENK(ub)YSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYFEYIEENKYSR 13 1 Q00839;Q00839-2;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PRI6 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 75847600.0 23520800.0 15228800.0 37098000.0 True False 30448139.264282923 14381303.892808901 30346544.657624703 1.0 0.4723212728364927 0.9966633558203212 24.859850729577428 -10.893175451143964 10.828630703977925 1.0185060404658524 0.734492314328407 0.25477242329557503 0.21406175899640897 0.08436357137627881 0.0008322459841735597 0.18283168245812154 0.06908813563774646 1.2788645497728704e-11 10.893175451143964 -0.28401372613744535 GYFEYIEENKYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYFEYIEENKYSR 13 1 Q00839;Q00839-2;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PRI6 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 13000200.0 1574200.0 5211500.0 6214500.0 False True 2063791.4445744872 4433964.514267893 5571483.153693329 1.0 2.1484557104470836 2.699634775761975 20.976865756616174 -9.43374221159693 0.2138175977733841 1.528991663515987e-23 3.174600277875291 0.9993866033957153 0.017535180285144992 0.8563043339722485 0.08362460774829174 0.8571334142145995 0.2913232564932029 3.6834755240634824e-10 9.43374221159693 3.174600277875291 GYFEYIEENKYSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYFEYIEENKYSR 13 1 Q00839;Q00839-2;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PRI6 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 23849800.0 1574200.0 11309600.0 10966000.0 False True 2156224.2811554205 10809904.476154098 8376056.651859266 1.0 5.013348829539 3.884594346266672 21.040075818139066 -10.120753750573678 6.598285470709184 0.9999945528199743 4.4489715879028395 0.9256425771146233 0.460812088149363 3.692463888332727e-05 4.921251220058733e-06 0.4461800874251344 0.14872646192779357 7.572621487203243e-11 10.120753750573678 3.4489770350828652 GYGAGVVTVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYGAGVVTVFK 11 0 Q9NX46 Q9NX46 ADPRHL2 Poly(ADP-ribose) glycohydrolase ARH3 0 11000200.0 2878300.0 3956700.0 4165200.0 False True 3773479.1734968526 3366375.783095804 3734225.059419658 1.0 0.8921145786995853 0.9895973682979631 21.84746388106337 -10.27968830356927 5.298359989292092 1.000009024820844 0.9408559736893766 0.3292192374963233 0.039797182203206334 4.243275746954181e-06 5.768769669399695e-07 0.0385393352701716 0.012844485324913786 5.25184253726471e-11 10.27968830356927 -0.059153051131467405 GYGAGVVTVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYGAGVVTVFK 11 0 Q9NX46 Q9NX46 ADPRHL2 Poly(ADP-ribose) glycohydrolase ARH3 0 10355100.0 2878300.0 2432100.0 5044700.0 False True 3942485.293132795 2324641.780120815 3853245.7588577885 1.0 0.5896386688290213 0.977364650051974 21.91067394258626 -10.58968195456397 9.306104771150109 1.0000328845457607 0.7835016606516726 0.29364427676577665 0.1582884690026943 0.0001080132592635386 4.762341408749701e-06 0.15328535411898414 0.051087383695341985 2.572278841601437e-11 10.58968195456397 -0.21653122389408808 GYGAGVVTVFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYGAGVVTVFK 11 0 Q9NX46 Q9NX46 ADPRHL2 Poly(ADP-ribose) glycohydrolase ARH3 0 7004500.0 3546900.0 1977300.0 1480300.0 False True 2949404.5043122093 1966647.892436682 1789823.8858661205 1.0 0.666794903703891 0.6068424603167483 21.49199226773105 -13.999999999999998 0.24124441506694297 3.2188726190891948 0.5806458987724498 0.999527041088593 0.0037611585921056073 13.667751166148962 0.15544993607314755 14.620616339811589 0.029082507238778806 1.0000000000000041e-14 13.999999999999998 -2.638226720316745 GYGCAGVSSVAYGLLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYGCAGVSSVAYGLLAR 17 0 Q92947;Q92947-2;K7EKT3 Q92947 GCDH Glutaryl-CoA dehydrogenase, mitochondrial 0 13427900.0 2730300.0 4594900.0 6102700.0 False True 3579449.7402628106 3909358.8307799175 5471251.145232009 1.0 1.0921675437445546 1.5285173817890507 21.77130639200652 -6.941030779005211 0.6499080416304248 0.9951759153527843 1.6498412348894231 0.998295764766016 0.009516129141521393 0.0872995969062656 0.05249265374674522 0.009337224628408755 0.037388497879738324 1.1454317603554877e-07 6.941030779005211 0.6546653195366389 GYGCAGVSSVAYGLLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYGCAGVSSVAYGLLAR 17 0 Q92947;Q92947-2;K7EKT3 Q92947 GCDH Glutaryl-CoA dehydrogenase, mitochondrial 0 11767600.0 6286900.0 1768000.0 3712700.0 False True 6087325.800775066 2473971.6199982003 2740232.4913874483 1.0 0.40641353871402824 0.45015374255778284 22.53737715192715 -9.780109719004415 6.4935174587245195 1.0000000068516102 0.42828364298974153 0.9956292163735708 0.017856863444397873 1.7781606090349425e-09 3.1741022685306636e-10 0.01728983394126681 0.0057632778945428 1.6591676867667844e-10 9.780109719004415 -0.5717163638618686 GYGCAGVSSVAYGLLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYGCAGVSSVAYGLLAR 17 0 Q92947;Q92947-2;K7EKT3 Q92947 GCDH Glutaryl-CoA dehydrogenase, mitochondrial 0 12816700.0 2730300.0 3509800.0 6576600.0 False True 3739765.693583178 3354725.4306434956 5023342.529328621 1.0 0.8970416078204183 1.343223865053324 21.83451645352941 -6.845974308558727 1.2543640852241982 0.9451934773101074 1.3597224536693828 0.9342441324760983 0.04891471067957918 0.161936566935823 0.4923445595600335 0.030543399729220374 0.07052090418162967 1.42569193037977e-07 6.845974308558727 0.41452897635927544 GYGFGLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYGFGLIK 8 0 P21796;C9JI87 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 0 16801700.0 4670300.0 3326400.0 8805000.0 False True 6122808.527249543 2830114.0862056464 7893943.063523988 1.0 0.4622248227443715 1.2892683199861659 22.545762137095572 -6.731213454531651 1.7188096024106665 0.6768064664359786 1.288885524701448 0.5648738947174069 0.22604713151760594 0.3339716820592071 1.933496281663363 0.10419611698226366 0.2582007463552608 1.8568915737195724e-07 6.731213454531651 0.6120790582654693 GYGFGLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYGFGLIK 8 0 P21796;C9JI87 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 0 6354210.0 2199200.0 815110.0 3339900.0 False True 2129387.5997812203 1140587.6737424962 2465079.9951477237 1.0 0.5356411739505216 1.1576473890432128 21.022007148229584 -6.706873700296266 1.8063628660257105 0.7136064060011178 1.1560516354972943 0.4501490696928391 0.19577819935988766 0.3814404043370889 2.42417688810283 0.08631415174981277 0.2201126922931976 1.9639313360877312e-07 6.706873700296266 0.4424452294961765 GYGFGLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYGFGLIK 8 0 P21796;C9JI87 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 0 13075700.0 4670300.0 3926300.0 4479100.0 False True 6397036.120111907 3752823.0834621764 3421228.829960136 1.0 0.586650288195735 0.5348146806931405 22.608972198618464 -13.999999999999998 0.2927777670236387 4.6181743922253045 0.5210805086759247 0.999633680354191 0.0039839012674052834 16.132933719703797 0.17165201323419968 35.21433938326627 0.019334544132137522 1.0000000000000041e-14 13.999999999999998 -4.0970938835493795 GYGFITFSDSECAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYGFITFSDSECAK 14 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;A0A0U1RQW2 Q14498-3 RBM39 RNA-binding protein 39 0 8649000.0 2609500.0 3258400.0 2781100.0 False True 3421079.7704339484 2772259.421143722 2493338.450194951 1.0 0.8103463254795936 0.7288162268951368 21.70602031361348 -13.999999999999952 0.11516012891070904 1.9081675084312089 0.5897794600690559 0.9997169800050186 0.0019112026153591296 11.984826877176836 0.10378211890684935 2.5084513196633824 0.12338572736703059 1.0000000000001104e-14 13.999999999999952 -1.318388048362153 GYGFITFSDSECAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYGFITFSDSECAK 14 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;A0A0U1RQW2 Q14498-3 RBM39 RNA-binding protein 39 0 10825300.0 2609500.0 2877400.0 5338400.0 False True 3574302.6690859273 2750266.953710637 4077579.867799155 1.0 0.769455529745044 1.1408043037502287 21.76923037513637 -6.738762165271419 1.6909685419096026 0.8626355647873589 1.1409759211687065 0.5995249124103523 0.09686806107399346 0.32003986169368775 1.7963038043256092 0.04532516595793715 0.11138653120718035 1.8248948044430783e-07 6.738762165271419 0.2783403563813476 GYGFVHFETQEAAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYGFVHFETQEAAER 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;E5RGH3 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 0 64022000.0 18568000.0 20222000.0 25232000.0 False True 24342827.812767804 17204956.424738616 22621234.68243466 1.0 0.7067772305284361 0.9292771922976767 24.536993434337443 -10.351523321771237 5.429666080174096 1.0000548266869194 0.8180272114130638 0.4714168312313032 0.09083522902058004 6.030513858493057e-05 7.202410721628476e-06 0.08797728986534512 0.029316944103801756 4.451195591964838e-11 10.351523321771237 -0.18202761527385558 GYGFVHFETQEAAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYGFVHFETQEAAER 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;E5RGH3 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 0 48391900.0 14371000.0 7548900.0 26472000.0 False True 13914800.471287688 10563215.136993444 19538189.05702281 1.0 0.759135221434901 1.4041300194953301 23.730116885770197 -6.8055694655851235 1.4330667064475606 0.8680273364081585 1.414306806173304 0.8479450347070725 0.10376952192714192 0.21290499402392396 0.862541695515212 0.05695059224477892 0.13202293410736948 1.5646980251005674e-07 6.8055694655851235 0.5462794697651454 GYGFVHFETQEAAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYGFVHFETQEAAER 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;E5RGH3 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 0 85248000.0 10111000.0 54858000.0 20279000.0 False True 15339126.21311365 45068161.29248968 16270846.761398548 1.0 2.9381178996988906 1.0607414356815419 23.870712966875587 -6.638711432908646 2.0486739750083656 2.268620125105606 1.0684593805195086 0.14984589686802463 0.8295229912198063 0.536626158722664 4.3027836344437915 0.3298818113458322 0.9188009347110613 2.2976748317115495e-07 6.638711432908646 -1.2001607445860976 GYGFVHFETQEAAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYGFVHFETQEAAER 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;E5RGH3 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 0 55636000.0 18568000.0 17318000.0 19750000.0 False True 25433091.381332643 16552833.497032309 15085456.764017934 1.0 0.650838439136099 0.5931428679995364 24.600203495860335 -13.999999999999998 0.25333823468586647 3.469702788185699 0.5706700621842912 0.9995490625456639 0.0038169384745929203 14.132808023669934 0.15926709579537096 17.79766887007385 0.02614096152867876 1.0000000000000041e-14 13.999999999999998 -2.899032726001408 GYGFVHFETQEAAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYGFVHFETQEAAER 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;E5RGH3 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 0 28450200.0 14371000.0 7872700.0 6206500.0 False True 11950123.243246444 7830288.202491393 7504250.454386337 1.0 0.6552474851601756 0.6279642729732791 23.510522161204474 -13.999999999999998 0.35959651067568665 5.499500059667637 0.6246601531357168 0.9997725580833475 0.0025534686416385432 21.653912057481516 0.1937736167430813 74.75850532070142 0.007883529481469689 1.0000000000000041e-14 13.999999999999998 -4.87483990653192 GYGFVHFETQEAAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYGFVHFETQEAAER 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YBN4;E5RGH3 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 0 53386000.0 10111000.0 28176000.0 15099000.0 False True 13088888.81760674 26607980.83130545 12351136.928822989 1.0 2.0328678165187926 0.9436352543700003 23.641839288968036 -6.658187362699538 1.979237329636858 1.665836964664485 0.9481861061538005 0.22793095112723472 0.43996368763644234 0.48877885644770125 3.678832381825735 0.1797077236139805 0.4876548260553693 2.196911879751356e-07 6.658187362699538 -0.7176508585106846 GYGFVSFFNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYGFVSFFNK 10 0 P31483-2;C9JTN7;H7BY49;F8W8I6;P31483;P31483-3 P31483-2;F8W8I6 TIA1 Nucleolysin TIA-1 isoform p40 0 41224000.0 12076000.0 14580000.0 14568000.0 False True 15831752.944150371 12404720.832394876 13060643.106123505 1.0 0.7835342603030109 0.8249650655993368 23.916317668506586 -10.429934777395351 5.973856441259239 1.0000769510794743 0.8042496629511752 0.9674948851888776 0.016914055434766446 1.734160085032936e-05 1.654850109854272e-06 0.016383383361648112 0.005458987917973259 3.715910306698077e-11 10.429934777395351 -0.19582728812829908 GYGFVSFFNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYGFVSFFNK 10 0 P31483-2;C9JTN7;H7BY49;F8W8I6;P31483;P31483-3 P31483-2;F8W8I6 TIA1 Nucleolysin TIA-1 isoform p40 0 46108200.0 19253000.0 8393200.0 18462000.0 False True 18641824.05355938 11744648.529959774 13626248.351872 1.0 0.6300160593843448 0.7309503787141618 24.15203969503393 -10.134672708743205 7.489008065530841 1.0000001056940668 0.6804832190492545 0.9303683669637955 0.041206263315531434 7.268266538738629e-08 8.414936360307188e-09 0.03989780597450745 0.01329926429837424 7.333770095609056e-11 10.134672708743205 -0.31951688664481237 GYGFVSFFNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYGFVSFFNK 10 0 P31483-2;C9JTN7;H7BY49;F8W8I6;P31483;P31483-3 P31483-2;F8W8I6 TIA1 Nucleolysin TIA-1 isoform p40 0 32533800.0 8363000.0 9274800.0 14896000.0 False True 12687282.417196082 7619639.475656855 11951799.070851272 1.0 0.6005730167501712 0.9420298751017041 23.596879744966582 -10.110290780036909 7.332246998054926 1.0000000685008028 0.7713014459259376 0.37426776387933725 0.13939917868917479 1.5616087570397476e-07 1.8926845091822122e-08 0.13497271460935933 0.04499089146151382 7.757275576025006e-11 10.110290780036909 -0.22869862257486517 GYGFVSFFNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYGFVSFFNK 10 0 P31483-2;C9JTN7;H7BY49;F8W8I6;P31483;P31483-3 P31483-2;F8W8I6 TIA1 Nucleolysin TIA-1 isoform p40 0 50610000.0 12076000.0 15261000.0 23273000.0 False True 16540823.541629314 14586718.558621667 17776396.72248047 1.0 0.8818616873525293 1.0746984077147979 23.979527730029478 -6.740934773824361 1.6832405467383682 0.9297825915742886 1.0748347112964993 0.6090864047904088 0.049636010221932245 0.3161576980826316 1.7591981387814084 0.02332455502985799 0.05717846831791932 1.8157883534047016e-07 6.740934773824361 0.14505211972221077 GYGFVSFFNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYGFVSFFNK 10 0 P31483-2;C9JTN7;H7BY49;F8W8I6;P31483;P31483-3 P31483-2;F8W8I6 TIA1 Nucleolysin TIA-1 isoform p40 0 38623900.0 19253000.0 7963900.0 11407000.0 False True 16009722.552517138 7920996.889989611 13792150.959991112 1.0 0.4947616589860408 0.8614859448530938 23.932444970468207 -9.814727134465805 6.743778143786636 1.0000000032694276 0.6781238019195486 0.506698463234189 0.14971456277688136 7.482909536680241e-09 1.2812283212024808e-09 0.14496050423994233 0.048320167359954286 1.5320497402467473e-10 9.814727134465805 -0.32187620134987904 GYGFVSFFNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYGFVSFFNK 10 0 P31483-2;C9JTN7;H7BY49;F8W8I6;P31483;P31483-3 P31483-2;F8W8I6 TIA1 Nucleolysin TIA-1 isoform p40 0 50435000.0 8363000.0 28025000.0 14047000.0 False True 10826068.359375458 26465384.114045117 11490590.134391464 1.0 2.4445979126970774 1.0613816348610552 23.36800606705903 -6.635944216240809 2.058422502730384 1.9475252959406273 1.0669990882568035 0.13951317387344664 0.6187189976821157 0.5436517075403686 4.397079062665353 0.24516319383798343 0.6854409441768075 2.3123617866940363e-07 6.635944216240809 -0.8805262076838238 GYGFVSFYNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYGFVSFYNK 10 0 Q01085;Q01085-2;E7ETJ9 Q01085 TIAL1 Nucleolysin TIAR 0 48716000.0 12335000.0 16808000.0 19573000.0 False True 16171304.452309927 14300311.917070867 17547773.71747358 1.0 0.8843016937343107 1.085118010685096 23.946932722180446 -6.75049172681338 1.6482286466831115 0.9320081567164386 1.0855273391425648 0.6510157813183816 0.04861813547504008 0.29918114081668695 1.5993159295791737 0.023301099461473865 0.05653507862955415 1.776267105350364e-07 6.75049172681338 0.15351918242612628 GYGFVSFYNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYGFVSFYNK 10 0 Q01085;Q01085-2;E7ETJ9 Q01085 TIAL1 Nucleolysin TIAR 0 41149600.0 15522000.0 5995600.0 19632000.0 False True 15029262.606313229 8389674.346640958 14489790.252624357 1.0 0.5582226198587261 0.964105201444663 23.841270891009888 -10.44562977606716 8.803255403918845 1.000003146569161 0.7611639106516945 0.3158541104666993 0.16570087006151815 1.023321324816658e-05 6.443248828833665e-07 0.1604412915183025 0.053479725850028276 3.584018344804157e-11 10.44562977606716 -0.23883923591746647 GYGFVSFYNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYGFVSFYNK 10 0 Q01085;Q01085-2;E7ETJ9 Q01085 TIAL1 Nucleolysin TIAR 0 63746000.0 18578000.0 16098000.0 29070000.0 False True 28184184.233728148 13225186.125751924 23324301.758166377 1.0 0.4692414020599993 0.8275670342182221 24.74838247476368 -10.071524793342228 5.599489388440402 1.0000022235996087 0.6484042181390145 0.5621179418604003 0.14628582675833843 4.060841358365723e-06 6.732037558637193e-07 0.14164153959880024 0.04721354756838321 8.481549609380982e-11 10.071524793342228 -0.35159800546059417 GYGFVSFYNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYGFVSFYNK 10 0 Q01085;Q01085-2;E7ETJ9 Q01085 TIAL1 Nucleolysin TIAR 0 46268000.0 12335000.0 15633000.0 18300000.0 False True 16895582.840841126 14942282.368582178 13977916.90033054 1.0 0.8843898733379413 0.8273119093910267 24.010142783703337 -13.999999998546798 0.09222179185192583 1.5865113173591883 0.6896310926475075 0.9998318854127312 0.0009314113379936601 12.144009316701947 0.08877126553912065 1.3860956273008789 0.12346410935128802 1.0000000033461212e-14 13.999999998546798 -0.8968802247116807 GYGFVSFYNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYGFVSFYNK 10 0 Q01085;Q01085-2;E7ETJ9 Q01085 TIAL1 Nucleolysin TIAR 0 36004100.0 15522000.0 9569100.0 10913000.0 False True 12907230.741192069 9517549.35898236 13194857.843989033 1.0 0.737381205141712 1.0222841838473555 23.621676166444164 -11.815623556823573 12.922639284779452 0.9098872293418993 0.8918494252212583 0.0 0.1323759848528061 0.0 0.0 0.0 0.03853413286765518 1.528890714977022e-12 11.815623556823573 -0.018037804120640932 GYGFVSFYNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYGFVSFYNK 10 0 Q01085;Q01085-2;E7ETJ9 Q01085 TIAL1 Nucleolysin TIAR 0 100823000.0 18578000.0 58139000.0 24106000.0 False True 24049587.227128662 54903513.54171163 19718955.348447416 1.0 2.282929558133073 0.8199290558385899 24.51950879685613 -6.675047663780189 1.91924663679927 1.8153004811364002 0.8256734351679356 0.3016748261266158 0.5443341825140329 0.44964686972908596 3.1976982890747556 0.22793052694027977 0.6050447746079408 2.1132570973333566e-07 6.675047663780189 -0.9896270459684646 GYGICHGTAGNGYSFLSLYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYGICHGTAGNGYSFLSLYR 20 0 Q9NS86 Q9NS86 LANCL2 LanC-like protein 2 0 18864900.0 4933000.0 12187000.0 1744900.0 False True 6467210.771239959 10368747.104553936 1564354.4862626928 1.0 1.60327960094703 0.24189013495887024 22.624712198987453 -6.786220078071984 1.5111644579976575 1.3388348317808174 0.2288338446941095 0.788922929635138 0.2558948239995808 0.2410309644935918 1.087369643353666 0.1333116617115998 0.3130277896392568 1.6359872772575561e-07 6.786220078071984 -1.1100009870867078 GYGICHGTAGNGYSFLSLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYGICHGTAGNGYSFLSLYR 20 0 Q9NS86 Q9NS86 LANCL2 LanC-like protein 2 0 35555000.0 4933000.0 10416000.0 20206000.0 False True 6756863.409312468 9955786.678894121 15433758.95563272 1.0 1.4734331709551538 2.2841602709271216 22.687922260510344 -6.962962986423052 0.39144222220782177 0.9510012493784984 2.835789846466945 0.9998648019171515 0.00616546313155099 0.07865917555717655 0.017340942703972396 0.010459394093539576 0.06815552215822328 1.0890229034359628e-07 6.962962986423052 1.8847885970884466 GYGICHGTAGNGYSFLSLYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYGICHGTAGNGYSFLSLYR 20 0 Q9NS86 Q9NS86 LANCL2 LanC-like protein 2 0 27362200.0 4949200.0 12089000.0 10324000.0 False True 6406836.963317114 11416236.522914935 8445137.933185559 1.0 1.7818834142775228 1.3181446603899722 22.611180847604306 -10.193939666194124 4.308371853193586 0.999818140809233 1.5500140373558768 0.6522461102591499 0.18932055358534133 133009178.7553558 83.88367450055974 244328.57731518536 0.0648094611105478 6.398237160007582e-11 10.193939666194124 0.5501958965466438 GYGK(ub)FQTAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYGKFQTAR 9 1 Q5T284;Q5T282;Q92966 Q5T284 SNAPC3 snRNA-activating protein complex subunit 3 1 4124320.0 681520.0 1075800.0 2367000.0 True False 882241.0747676151 1015930.7842957977 1936230.2874709626 1.0 1.1515342159323028 2.194672570624726 19.750813404424942 -6.9330017690659105 0.7217298858276515 0.9857684685430205 2.4261667062400294 0.9970959937941881 0.028618880587564514 0.09110880406583716 0.07026288068316057 0.026555361269132258 0.09287723907085589 1.1668048641594188e-07 6.9330017690659105 1.4403982376970088 up GYGYGQGAGTLSTDKGESLGIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYGYGQGAGTLSTDKGESLGIK 22 1 P21291;E9PS42;E9PND2;E9PP21 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 42701500.0 14767000.0 5124500.0 22810000.0 False True 14298229.668047141 7170739.573914475 16835376.71466797 1.0 0.5015124068079022 1.17744483796415 23.769333195324496 -6.7090896946444145 1.7984293588647005 0.6932703575217432 1.175821328135246 0.4609142677161969 0.21008764330990598 0.3768413326714995 2.3753411023380657 0.0929824891078254 0.2364821404327265 1.9539358686025716e-07 6.7090896946444145 0.48255097061350294 GYGYGQGAGTLSTDKGESLGIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYGYGQGAGTLSTDKGESLGIK 22 1 P21291;E9PS42;E9PND2;E9PP21 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 46534000.0 10705000.0 13150000.0 22679000.0 False True 14662927.791747395 12568989.51876515 17322687.288666453 1.0 0.8571950770868041 1.181393479848958 23.805669863788722 -6.786963975823034 1.508394096549924 0.919870629360515 1.1845613302020699 0.791357751635127 0.06059816037674828 0.2399045134889213 1.078356409942521 0.031627124221134555 0.07421541958633053 1.6331874131023778e-07 6.786963975823034 0.2646907008415549 GYHTFCVGLGAIPSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYHTFCVGLGAIPSGR 16 0 Q8WUB8-3;Q8WUB8-2;Q8WUB8 Q8WUB8-3 PHF10 PHD finger protein 10 0 22441200.0 5650900.0 9285100.0 7505200.0 False True 7408384.623393448 7899799.273036332 6728633.898961983 1.0 1.0663322268786024 0.9082457568030394 22.8207275707109 -6.792770818310192 1.4856932268128231 1.036940214011775 0.9064444832784035 0.8100376006226641 0.028249885339094866 0.23125066841591033 1.0083676787802869 0.014965835456442991 0.03496247820244035 1.6114958138424268e-07 6.792770818310192 -0.1304957307333714 GYHTFCVGLGAIPSGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYHTFCVGLGAIPSGR 16 0 Q8WUB8-3;Q8WUB8-2;Q8WUB8 Q8WUB8-3 PHF10 PHD finger protein 10 0 7742200.0 3593100.0 1741800.0 2407300.0 False True 3479039.0072635026 2437309.8233670075 1776755.9125480119 1.0 0.7005698465232545 0.5107030731298265 21.730257423984803 -8.888417587423946 0.1108249835100607 1.5831803353826723 1.51075231705052e-15 0.9999535645147617 0.0013725155925351845 0.3872521308263002 0.03358028277783675 0.26296967820934186 0.193474260784877 1.2929520306521737e-09 8.888417587423946 -1.5831803353826708 GYHTFCVGLGAIPSGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYHTFCVGLGAIPSGR 16 0 Q8WUB8-3;Q8WUB8-2;Q8WUB8 Q8WUB8-3 PHF10 PHD finger protein 10 0 38073900.0 9526900.0 11237000.0 17310000.0 False True 14453003.809683759 9231669.554918263 13888670.912757484 1.0 0.6387370872159382 0.960953937025315 23.784866027593058 -10.279230257920785 7.874235372399764 1.000000422527178 0.7998455134066746 0.33970963551313227 0.13154447809332934 9.757162088250945e-07 8.942227759961342e-08 0.12736766273313702 0.04245579774508425 5.257384520270484e-11 10.279230257920785 -0.20015490912050327 GYHTFCVGLGAIPSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYHTFCVGLGAIPSGR 16 0 Q8WUB8-3;Q8WUB8-2;Q8WUB8 Q8WUB8-3 PHF10 PHD finger protein 10 0 24461500.0 5650900.0 7154600.0 11656000.0 False True 7740190.439830492 6838486.114901676 8903092.862855349 1.0 0.8835035995640743 1.1502420944374494 22.883937632233792 -6.788004550416222 1.5042893822139385 0.9347190783755026 1.1529246998722253 0.7947674129451878 0.049463934157609156 0.23835647308895477 1.0655788828076844 0.02588476062257489 0.06069200923867723 1.6292789614206178e-07 6.788004550416222 0.21820562149672273 GYHTFCVGLGAIPSGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYHTFCVGLGAIPSGR 16 0 Q8WUB8-3;Q8WUB8-2;Q8WUB8 Q8WUB8-3 PHF10 PHD finger protein 10 0 10277600.0 3593100.0 1258000.0 5426500.0 False True 2987821.8513192404 1251222.9043065514 6561156.060698851 1.0 0.4187742665293406 2.1959662882182363 21.51066269941908 -6.8186202634229645 1.3779026711822193 0.686281845206663 2.233607398368551 0.88116671679759 0.2550469480229388 0.19527984086576997 0.7289078216812688 0.1454711755896924 0.3354060098678602 1.5183774196466282e-07 6.8186202634229645 1.5473255531618881 up GYHTFCVGLGAIPSGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYHTFCVGLGAIPSGR 16 0 Q8WUB8-3;Q8WUB8-2;Q8WUB8 Q8WUB8-3 PHF10 PHD finger protein 10 0 37210900.0 9526900.0 17478000.0 10206000.0 False True 12332759.853274422 16505333.935603203 8348612.722403301 1.0 1.3383325494026332 0.6769460219552312 23.555992349685507 -6.767652945962578 1.5834638597316744 1.1946399120046056 0.6735537569382182 0.7214938864680306 0.14250683944810105 0.27024144690988544 1.3368909058031468 0.07095352014915382 0.16926332439145914 1.707446300933876e-07 6.767652945962578 -0.5210861550663874 GYHYATCLEGALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYHYATCLEGALK 13 0 Q06210-2;Q06210;A0A6I8PRN4 Q06210-2 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 0 7241300.0 2412400.0 2798600.0 2030300.0 False True 3162679.761714831 2381059.788857362 1820224.0320128053 1.0 0.7528614871732482 0.5755321971092846 21.592716051965624 -7.390638946265539 0.11095565501580582 1.397618390729831 1.3605568387019138e-10 0.9999973696616828 0.0002822494634793254 0.12162882540072495 0.007786319331120119 0.036790453687928285 0.05778196060633188 4.067813691468441e-08 7.390638946265539 -1.3976183905937754 GYHYATCLEGALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYHYATCLEGALK 13 0 Q06210-2;Q06210;A0A6I8PRN4 Q06210-2 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 0 6614300.0 2412400.0 1816900.0 2385000.0 False True 3304329.472658703 1736623.350315163 1821712.1206168465 1.0 0.5255599856747503 0.5513106776096014 21.655926113488515 -10.594533160774995 6.4215663787185635 1.0011494771295188 0.5384353316421763 0.9976710430885567 0.010512675960664561 0.00017338473409776533 1.094773811414124e-05 0.010201248923551755 0.003392951576644074 2.543705559788919e-11 10.594533160774995 -0.4627141454873426 GYIFLEYASPAHAVDAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYIFLEYASPAHAVDAVK 18 0 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 16716300.0 3902300.0 8432200.0 4381800.0 False True 5115953.089926958 7174148.628458166 3928413.3691935726 1.0 1.4023093062725078 0.7678751740176061 22.28657160499798 -6.735394337687795 1.7038850904338487 1.2406490624034754 0.7678892260199649 0.5839215638976272 0.16906175950164995 0.32622855474952217 1.8578464648772426 0.07855872860485401 0.19373495772816296 1.8391013462936024e-07 6.735394337687795 -0.4727598363835105 GYIFLEYASPAHAVDAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYIFLEYASPAHAVDAVK 18 0 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 23080000.0 7440200.0 5608800.0 10031000.0 False True 7204014.923559583 7848423.089505603 7403580.176450426 1.0 1.0894512536111753 1.0277019488449692 22.780369739202886 -10.296816729037882 4.426907528590898 0.9999548368205197 1.0585766012284579 0.5454212404315038 0.025209048109761968 1.1245801750320026e-05 1.7862857287768133e-06 0.024427371071307897 0.00813618529167652 5.048743080514543e-11 10.296816729037882 0.058621764407938204 GYIFLEYASPAHAVDAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYIFLEYASPAHAVDAVK 18 0 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 143075000.0 30038000.0 72194000.0 40843000.0 False True 45569842.07195213 59310416.64570346 32770363.147877175 1.0 1.3015278076245198 0.7191239130505364 25.441576034939327 -6.766000336990651 1.5897031061971563 1.1738360005363977 0.7163297985314929 0.7149998123079695 0.12695862509420028 0.27297391719131064 1.3607792445694724 0.0629726193167955 0.1504614023594069 1.7139559775643677e-07 6.766000336990651 -0.45750620200490477 GYIFLEYASPAHAVDAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYIFLEYASPAHAVDAVK 18 0 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 21795100.0 3902300.0 8940200.0 8952600.0 False True 5345085.765692284 8545192.402712101 6838180.264584652 1.0 1.5987007088941154 1.2793396709321063 22.349781666520872 -10.082310261286125 4.510666609915835 0.9999703807442707 1.4390201899322703 0.7158825458370954 0.1303785978676904 90595818.49769635 2.5184499854510207 29967.87223588873 0.04463206190568669 8.273508905653209e-11 10.082310261286125 0.43904980918799963 GYIFLEYASPAHAVDAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYIFLEYASPAHAVDAVK 18 0 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 20392100.0 7440200.0 6649500.0 6302400.0 False True 6186855.9567463845 6613677.823677587 7620202.70099483 1.0 1.0689884926875952 1.2316761137271135 22.560775014637162 -6.956700607970005 0.47967721449114203 0.9960831525240625 1.311360634843505 0.9996275804273135 0.0018743385941975266 0.0809014594958785 0.02565125135179689 0.002292348792762924 0.013420504678383795 1.104840007201739e-07 6.956700607970005 0.3152774823194424 GYIFLEYASPAHAVDAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYIFLEYASPAHAVDAVK 18 0 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 118544000.0 30038000.0 51629000.0 36877000.0 False True 38884783.137500875 48755800.76446155 30165764.38997322 1.0 1.253852968449269 0.7757729876827075 25.212702357031777 -6.7625009942958005 1.6035719980258425 1.1469970512392331 0.7738389006348583 0.7008933390850447 0.10681094406366234 0.27873862508255354 1.41328668462959 0.05254613137942559 0.12594070614403385 1.7278220247400113e-07 6.7625009942958005 -0.37315815060437485 GYIFLEYASPAHAVDAVK(ub)NADGYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYIFLEYASPAHAVDAVKNADGYK 24 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 77439000.0 19612000.0 47396000.0 10431000.0 True False 29752837.829253804 38937813.49336177 8369308.277930286 1.0 1.3087092302528887 0.2812944541949324 24.82652394362157 -6.826134491378538 1.345063505892299 1.1654390116868025 0.25575924220979884 0.8979424502050135 0.1375066935794213 0.18561649741715536 0.6581083607427809 0.08029798728333638 0.1848481699560216 1.49233219579804e-07 6.826134491378538 -0.9096797694770037 down GYIFLEYASPAHAVDAVK(ub)NADGYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYIFLEYASPAHAVDAVKNADGYK 24 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 30196600.0 5927100.0 17084600.0 7184900.0 True False 4928646.265050863 16992561.868772414 8687229.370775852 1.0 3.4477138254508213 1.7625994854565206 22.232760010067537 -9.477974427980325 8.576504795997659 0.9999908986319815 2.605156655453714 0.5474710753897492 0.6879450485590205 0.0 0.0 0.6660999290346049 0.22203330967820156 3.326791414477766e-10 9.477974427980325 1.6051657568217323 GYIFLTLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYIFLTLR 8 0 Q9BRZ2 Q9BRZ2 TRIM56 E3 ubiquitin-protein ligase TRIM56 0 30462900.0 7502500.0 9617400.0 13343000.0 False True 11381841.006219495 7901099.828910836 10705750.201555347 1.0 0.694184695129141 0.9405991698272095 23.440230595821536 -9.932272647255466 6.12733458028026 1.0000000523839259 0.8173919333399845 0.42270872915323743 0.1005982880411451 7.197044499105073e-08 1.2554541587637928e-08 0.0974039011371729 0.032467957853345164 1.168765417312891e-10 9.932272647255466 -0.18260811904394136 GYIFLTLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYIFLTLR 8 0 Q9BRZ2 Q9BRZ2 TRIM56 E3 ubiquitin-protein ligase TRIM56 0 27010100.0 7502500.0 10269000.0 9238600.0 False True 9712134.146384599 9697521.122823521 7557269.59604107 1.0 0.9984953849132616 0.7781265664307478 23.211356917913985 -6.908397393966843 0.9065800529782551 1.007173679733156 0.7506027503435754 0.9903025857700356 0.010265011172392821 0.1054872997209708 0.14458670577209173 0.008338070178546006 0.02276909306037247 1.2348170174955417e-07 6.908397393966843 -0.2565709293895807 GYISPYFINTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYISPYFINTSK 12 0 P10809;E7ESH4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 370937300.0 100720000.0 74687300.0 195530000.0 False True 132044895.37386739 63544245.968815155 175298431.25620034 1.0 0.48123212782211805 1.3275668912445753 26.976453289599338 -6.740834341011232 1.6835312862917258 0.6916320935145188 1.328164368789324 0.6087098832948403 0.21796120166145164 0.3163175217521204 1.7606433258759666 0.10240512306333606 0.25107392022724995 1.81620831227591e-07 6.740834341011232 0.6365322752748053 GYISPYFINTSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYISPYFINTSK 12 0 P10809;E7ESH4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 306319000.0 84215000.0 68044000.0 154060000.0 False True 81541640.92196035 95214324.04477246 113707064.29906817 1.0 1.1676773114720316 1.3944662262547771 26.281033653735502 -6.966919903866995 0.32341191352362764 0.9701589536317357 1.599336453508847 0.9999474248995365 0.0011720289213980693 0.07731538042045986 0.012594146785376032 0.003391431097394273 0.019889681632167915 1.0791457287411962e-07 6.966919903866995 0.6291774998771114 GYISPYFINTSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYISPYFINTSK 12 0 P10809;E7ESH4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 713668000.0 115100000.0 495750000.0 102818000.0 False True 174615114.9371358 407279539.1875705 82495977.23326965 1.0 2.332441491873127 0.47244465213088516 27.379603205242837 -6.7144231086913395 1.7795743948956615 1.815429708943502 0.47624363484908316 0.4860407563443966 0.5611113131708422 0.3662422776606558 2.263566033378726 0.25067420915016725 0.6334056549675667 1.9300870254962002e-07 6.7144231086913395 -1.3391860740944188 GYISPYFINTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYISPYFINTSK 12 0 P10809;E7ESH4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 347500000.0 100720000.0 111140000.0 135640000.0 False True 137958905.855656 106229467.30916798 103604625.59348819 1.0 0.7700080444267514 0.7509817865755467 27.03966335112223 -13.99999999998784 0.35310887062610335 3.883229982025626 0.748460311006819 0.9997605852068969 0.0017510838777882506 20.97340030363257 0.19151560027722142 45.42504329019964 0.0056172796906158 1.0000000000279975e-14 13.99999999998784 -3.134769671018807 GYISPYFINTSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYISPYFINTSK 12 0 P10809;E7ESH4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 174130000.0 84215000.0 51841000.0 38074000.0 False True 70028503.8570732 51561722.243367165 46035097.36571418 1.0 0.7362962137332482 0.6573765656863226 26.06143892916978 -13.999999999996733 0.16906104482956255 2.326628464357355 0.5870599518886905 0.9995155000316641 0.0032246470974750412 12.082511123035584 0.13018538307294722 5.256229747391528 0.06489638284601586 1.000000000007522e-14 13.999999999996733 -1.7395685124686646 GYISPYFINTSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYISPYFINTSK 12 0 P10809;E7ESH4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 409905000.0 115100000.0 136543000.0 158262000.0 False True 148999218.96019527 128944262.01905654 129459939.90525094 1.0 0.8654022680045299 0.868863211557074 27.150729527335287 -10.490833518596107 8.723894817024796 1.0000048028956567 0.8671327397808061 0.9994913715640041 0.001412924288718064 1.319937328392495e-07 7.702519728716007e-09 0.0013681075043818984 0.0004560193533047521 3.229731962137433e-11 10.490833518596107 -0.13287206311485067 GYIWNYGAIPQTWEDPGHNDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYIWNYGAIPQTWEDPGHNDK 21 0 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 16783700.0 3631100.0 7585500.0 5567100.0 False True 4760407.263622425 6453772.968047411 4991069.895394018 1.0 1.355718662427303 1.0484543903489616 22.182653573965432 -9.894338903175106 10.03257390616556 0.999999813177694 1.2020865264116691 0.3657849690049997 0.1254401137966525 0.0 0.0 0.12145686792017865 0.04048562264005954 1.2754431239918585e-10 9.894338903175106 0.2020867132339751 GYIWNYGAIPQTWEDPGHNDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYIWNYGAIPQTWEDPGHNDK 21 0 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 30334400.0 8681100.0 4190300.0 17463000.0 False True 8405523.232293895 5863508.642125821 12888916.421229577 1.0 0.6975780662408151 1.5333865679783685 23.002906197368663 -6.808855541581903 1.419683998192644 0.8349603797200167 1.5475805691378675 0.8567262891322825 0.1307893877229257 0.2083713943213394 0.8279988198447237 0.0724488987359951 0.16765094906974015 1.5529034629226024e-07 6.808855541581903 0.7126201894178508 GYIWNYGAIPQTWEDPGHNDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYIWNYGAIPQTWEDPGHNDK 21 0 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 26993100.0 3631100.0 11227000.0 12135000.0 False True 4973615.79678786 10730954.017275756 9268962.928170007 1.0 2.157575988118381 1.8636266464643765 22.245863635488323 -10.131542584472923 4.620592970806908 0.9999022265287855 2.0106013173073474 0.940333774678027 0.12000431627181869 0.0001213194287870266 2.2802262951528745e-05 0.11620482980235936 0.038731226524541425 7.386818284592327e-11 10.131542584472923 1.0106990907785618 GYIWNYGAIPQTWEDPGHNDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYIWNYGAIPQTWEDPGHNDK 21 0 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 18222000.0 8681100.0 5547200.0 3993700.0 False True 7218719.287937285 5517316.132567004 4828764.205217539 1.0 0.7643067852474357 0.6689225626610196 22.78331147280294 -13.999999998661051 0.12457247325382174 2.120637561603688 0.5256569391765826 0.9996708318884218 0.002524570335294194 11.948544115332357 0.1091856756331571 3.296500570851954 0.12721096899172088 1.0000000030830429e-14 13.999999998661051 -1.5949806224271053 GYIYVEAYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYIYVEAYK 9 0 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 5515400.0 2021000.0 1491300.0 2003100.0 False True 1956844.4612394674 2086783.867026763 1478428.018288094 1.0 1.0664025211819808 0.7555163670758258 20.900097657983725 -6.850856744184001 1.2310077641583026 1.03546133541239 0.7428855446704377 0.9415346248804427 0.03232317343504328 0.1565179987173802 0.45600061741500864 0.020542243872520898 0.04756101279587593 1.4097537412803812e-07 6.850856744184001 -0.2925757907419524 GYIYVEAYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYIYVEAYK 9 0 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 15970200.0 5242200.0 6285800.0 4442200.0 False True 7952800.6561551085 5164049.87882044 3564197.222914577 1.0 0.6493372714961362 0.44816881209716347 22.92303157830145 -9.969923737435742 0.11638998715508499 1.7583605251017924 3.1777149998407094e-14 0.9998855399054685 0.0024395215389161843 1.5474881204463566 0.05365151699379169 0.5929977386468351 0.24198925965742615 1.071707481667363e-10 9.969923737435742 -1.7583605251017607 GYIYVEAYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYIYVEAYK 9 0 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 11571100.0 5242200.0 6328900.0 0.0 False True 6786131.239210561 5976691.151449783 0.0 1.0 0.8807214214950931 0.0 22.6941579003939 -7.139193786948387 0.9485317588625322 0.9953006529632844 3.459304512096421e-20 0.9896976762481694 0.04526478184231946 0.08696914961212475 0.14820561686206535 0.037770002904254966 0.06639902559345526 7.257820332890075e-08 7.139193786948387 -0.9953006529632844 down GYK(ub)YNPMYSEPVDQEYLPEELR ddPTM_RPMI8226_Bortezomib_2h_R1 2 GYKYNPMYSEPVDQEYLPEELR 22 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 54394600.0 20002400.0 15975200.0 18417000.0 True False 19367434.760760207 22354180.669567466 13593035.201843053 1.0 1.1542148428897057 0.7018500575710472 24.207129544171774 -6.81470006849503 1.3946018967101323 1.0835926417161201 0.6930498429262183 0.8717618057643944 0.06724019768712888 0.20046265570320523 0.7674671894270715 0.03790091782468437 0.08750460935483853 1.5321452231676192e-07 6.81470006849503 -0.39054279878990183 GYK(ub)YNPMYSEPVDQEYLPEELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYKYNPMYSEPVDQEYLPEELR 22 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 52785000.0 14897000.0 19066000.0 18822000.0 True False 22599838.116581358 15663523.336662088 15101823.450024346 1.0 0.6930812183636775 0.6682270630489267 24.429809102814755 -13.999999999999998 0.356229695275601 4.922741567208166 0.6650711600516487 0.9997663954208147 0.002306102463874478 21.295366066022495 0.19258947051410066 63.398146140092564 0.0072614190650960135 1.0000000000000041e-14 13.999999999999998 -4.2576704071565175 GYK(ub)YNPMYSEPVDQEYLPEELR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 GYKYNPMYSEPVDQEYLPEELR 22 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 75494800.0 22463800.0 25100600.0 27930400.0 True False 29079831.927698005 23703729.544799313 22847353.79010519 1.0 0.8151260847633011 0.7856769546299718 24.793515595168586 -13.999999999853333 0.25855477297432733 2.3432292112993394 0.7747635581603011 0.9995593954469953 0.00199108707322739 14.353435328019533 0.16090185473666274 10.064795833733182 0.012973279516395621 1.0000000003377125e-14 13.999999999853333 -1.5684656531390382 GYLALCSYNCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYLALCSYNCK 11 0 G5EA36;P30260;P30260-2;I3L328 G5EA36 CDC27 Cell division cycle protein 27 homolog 0 4086400.0 1183900.0 1556400.0 1346100.0 False True 1552104.364903908 1324191.1867996834 1206818.484702967 1.0 0.8531585998610764 0.7775369440299733 20.56579413823264 -13.999999997478074 0.08464611584290378 1.7713589975653445 0.5699143962601412 0.999866805418244 0.0010658934880429505 12.213244649665373 0.08317857979020962 1.7291714045229598 0.187538253256971 1.0000000058069487e-14 13.999999997478074 -1.2014446013052034 GYLLFLTNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYLLFLTNR 9 0 P0C7V7 P0C7V7 SEC11B Putative signal peptidase complex catalytic subunit SEC11B 0 33674300.0 5730300.0 18978000.0 8966000.0 False True 8693284.041044913 15591227.624209221 7193866.170062592 1.0 1.793479604554045 0.8275199724404617 23.05146985277467 -6.6883965503783385 1.8717906127381378 1.4981914756314816 0.8308896213461123 0.3631072324370934 0.3356936052615402 0.42010623447663 2.852374806964336 0.14352941075520334 0.3745622815389875 2.049290135924314e-07 6.6883965503783385 -0.6673018542853693 GYLLFLTNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYLLFLTNR 9 0 P0C7V7 P0C7V7 SEC11B Putative signal peptidase complex catalytic subunit SEC11B 0 20398200.0 5730300.0 9029600.0 5638300.0 False True 7417986.311099977 8527094.822343688 4612187.2538434835 1.0 1.1495161172762054 0.6217573153164211 22.82259617486712 -6.831043130864654 1.3234073286338617 1.079834418300665 0.6072681131298143 0.9079062257867617 0.06740030535228894 0.17953548162618777 0.6146193735516403 0.03998483911035794 0.09200649589454428 1.4755599844686504e-07 6.831043130864654 -0.47256630517085063 GYMDLMPFINK ddPTM_RPMI8226_Bortezomib_1h_R1 2 GYMDLMPFINK 11 0 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 0 33601080.0 9332150.0 8776730.0 15492200.0 False True 12234539.022669157 7467276.09542558 13889215.755675904 1.0 0.6103438864014082 1.135246348876801 23.544456408273874 -6.7079032876005 1.802581519575772 0.7599345400930163 1.1339426227393739 0.4551386042110436 0.164254319217057 0.3793284277360826 2.4013021088359348 0.072548216037507 0.18478341087030506 1.9592809343189863e-07 6.7079032876005 0.37400808264635754 GYMDLMPFINK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYMDLMPFINK 11 0 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 0 20431600.0 6353000.0 2917600.0 11161000.0 False True 6151327.492456378 4082612.8950830013 8237599.2771770805 1.0 0.663696234689126 1.3391579764334092 22.55246635540478 -6.771330804432367 1.5693901767273146 0.8074346099725176 1.3431475604187941 0.7356264214310904 0.14178668454812868 0.2642764696677727 1.2847795730621172 0.07120491569593797 0.1692890467611191 1.693047705670543e-07 6.771330804432367 0.5357129504462765 GYMDLMPFINK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 GYMDLMPFINK 11 0 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 0 30731210.0 9332150.0 9697610.0 11701450.0 False True 12782498.046871137 9269137.524492174 8937808.508927466 1.0 0.7251428860386994 0.6992223645295402 23.607666469796765 -13.999999999999998 0.33399963100113506 4.065163649216879 0.6948440507963601 0.9997230811518053 0.0022646573124414536 19.166842769668083 0.18502875892624943 41.35445892310243 0.008184274213033669 1.0000000000000041e-14 13.999999999999998 -3.3703195984205183 GYMDLMPFINK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYMDLMPFINK 11 0 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 0 12422500.0 6353000.0 2700900.0 3368600.0 False True 5282800.985619971 2686349.715613323 4072958.685353389 1.0 0.5085085966565258 0.7709846909698419 22.332871630839055 -10.160205385675534 5.166852058903471 1.000016501118752 0.6397466438128941 0.7152411658283367 0.10715541679205712 2.0369273518570966e-05 3.310598672163698e-06 0.10375753473711122 0.034584262057483516 6.915038689557288e-11 10.160205385675534 -0.3602698573058579 GYMDLMPFINK(ub)AGCECLNESDEHGFDNCLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYMDLMPFINKAGCECLNESDEHGFDNCLR 30 1 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 1 26113600.0 6841700.0 6743900.0 12528000.0 True False 8856715.520069227 6368596.03663546 10248032.548135279 1.0 0.7190697298794668 1.1570917599095671 23.07834034920746 -6.733482437064953 1.7103982841037588 0.8315970739080003 1.157007722773868 0.5753782798321962 0.118067767812928 0.32975536613330175 1.8914082799059315 0.05466692682769373 0.13512769394524077 1.8472154950753418e-07 6.733482437064953 0.3254106488658677 GYNHGQGSYSYSNSYNSPGGGGGSDYNYESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYNHGQGSYSYSNSYNSPGGGGGSDYNYESK 31 0 Q12906-7;Q12906 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 16807100.0 4038100.0 7189800.0 5579200.0 False True 5293988.205016024 6117109.865620891 5001917.903465413 1.0 1.1554823374606242 0.9448298163426437 22.33592354984244 -6.709004349905102 1.7991297125787615 1.0956874966170398 0.9453475731858512 0.4601756808131714 0.06553000799502737 0.37709314668337207 2.3788144060884413 0.02899442492452815 0.07373818540615819 1.954319881157363e-07 6.709004349905102 -0.15033992343118863 GYNHGQGSYSYSNSYNSPGGGGGSDYNYESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYNHGQGSYSYSNSYNSPGGGGGSDYNYESK 31 0 Q12906-7;Q12906 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 18388000.0 5195500.0 1453500.0 11739000.0 False True 5030571.696372921 2033890.1299023677 8664203.737548772 1.0 0.4043059621571078 1.722309960077843 22.26229093290454 -6.783816506114609 1.520841681426492 0.6643758052226303 1.7340577737593152 0.7807142744571238 0.25235578078355037 0.244688484196576 1.118033757297043 0.1306563481440986 0.3073461826817036 1.6450666339737458e-07 6.783816506114609 1.069681968536685 GYNHGQGSYSYSNSYNSPGGGGGSDYNYESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYNHGQGSYSYSNSYNSPGGGGGSDYNYESK 31 0 Q12906-7;Q12906 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 15334600.0 4038100.0 4489900.0 6806600.0 False True 5531094.69554929 4291521.371886203 5199021.266327318 1.0 0.775890055785786 0.9399624400773355 22.399133611365333 -10.442627941821932 4.940231411450989 1.0002505918257794 0.8579262479315464 0.49993981898104844 0.06698227039940485 0.00018519853150313485 2.0894795308701176e-05 0.06496917295109052 0.021618434812330983 3.608876815208802e-11 10.442627941821932 -0.14232434389423299 GYNHGQGSYSYSNSYNSPGGGGGSDYNYESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYNHGQGSYSYSNSYNSPGGGGGSDYNYESK 31 0 Q12906-7;Q12906 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 9430400.0 5195500.0 2829200.0 1405700.0 False True 4320288.449675524 2813958.538047768 1699625.3707775488 1.0 0.6513358010294685 0.3934055308055182 22.042696208338818 -7.799653317158452 0.1860187403362917 1.253570801669585 1.0784262068294199e-09 0.9999186599648191 0.0022417492318885577 0.12653182086189266 0.02608127413375152 0.0603524799747251 0.09156716400016132 1.586158865092751e-08 7.799653317158452 -1.2535708005911588 down GYPEVALHFVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYPEVALHFVK 11 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3IU89 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 8482400.0 2278300.0 2389800.0 3814300.0 False True 2986873.363088588 2033251.1553674415 3419632.8253491777 1.0 0.6807289456908713 1.144887114267574 21.510204641148626 -6.721598504889068 1.7533394944076355 0.8060896713332759 1.1442387309153987 0.5200803745032698 0.1343254611324361 0.35225727346891395 2.117159163276195 0.060806990604523346 0.15237494503192348 1.8984601923275571e-07 6.721598504889068 0.3381490595821228 GYPEVALHFVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYPEVALHFVK 11 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3IU89 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 10219300.0 2278300.0 2662800.0 5278200.0 False True 3120649.0787424697 2545148.6912979316 4031597.8679412347 1.0 0.8155831133449815 1.2919100373714083 21.573414702671517 -6.801775071965679 1.4491070784522253 0.8984767730346824 1.2987424329203914 0.8371694156322862 0.07913212033213782 0.21824239646986174 0.9046538145260622 0.04295993467917448 0.0997826053154982 1.5784285513445213e-07 6.801775071965679 0.40026565988570895 GYPGDYTK(ub)GVEITGFPEAQALGLEVFHAGTALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYPGDYTKGVEITGFPEAQALGLEVFHAGTALK 33 1 P22102;P22102-2 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 89868000.0 13759000.0 24928000.0 51181000.0 True False 20873408.917637303 20479403.636647027 41065052.91657079 1.0 0.9811240568062002 1.9673381132236742 24.31516289609199 -6.9025393718894374 0.9450935326401709 0.9618045240385317 2.076359265148618 0.9877873415933255 0.05089260415974414 0.10955960747136667 0.16707339934381507 0.04018689666537714 0.10595432759842302 1.2515858027169132e-07 6.9025393718894374 1.1145547411100862 GYPGDYTK(ub)GVEITGFPEAQALGLEVFHAGTALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYPGDYTKGVEITGFPEAQALGLEVFHAGTALK 33 1 P22102;P22102-2 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 126558500.0 13759000.0 14841000.0 97958500.0 True False 17811296.730437264 14015085.303712519 80131058.13908926 1.0 0.786864960806728 4.498889628970998 24.08628921818444 -6.893286698994046 1.002720983731297 0.8159782084204791 4.83951995646441 0.9829204724072551 0.22241311101306083 0.11651756792819658 0.20658712951563885 0.16823346004486786 0.42469511965603063 1.2785370008002317e-07 6.893286698994046 4.023541748043931 up GYPHWPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYPHWPAR 8 0 O75475-3;O75475-2;O75475;H3BPQ6;P51858;Q7Z4V5-2;Q7Z4V5;Q7Z4V5-4;Q7Z4V5-3;M0R0J3;Q9Y3E1 O75475-3;P51858;Q7Z4V5-2 PSIP1;HDGFRP3;HDGF;HDGFRP2 PC4 and SFRS1-interacting protein;Hepatoma-derived growth factor;Hepatoma-derived growth factor-related protein 2;Hepatoma-derived growth factor-related protein 3 0 9720100.0 2123700.0 4065900.0 3530500.0 False True 2784191.2659400576 3459283.5687540662 3165197.7269473514 1.0 1.2424733929283662 1.1368463674418756 21.408826892919187 -10.26144048787769 4.806537159481733 0.9999465401630153 1.1896598801853067 0.8112753220398593 0.04312205258268821 2.4712560869366443e-05 3.79722808426747e-06 0.04176450278307526 0.013917582625437372 5.4772115099417224e-11 10.26144048787769 0.18971334002229134 GYPHWPAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYPHWPAR 8 0 O75475-3;O75475-2;O75475;H3BPQ6;P51858;Q7Z4V5-2;Q7Z4V5;Q7Z4V5-4;Q7Z4V5-3;M0R0J3;Q9Y3E1 O75475-3;P51858;Q7Z4V5-2 PSIP1;HDGFRP3;HDGF;HDGFRP2 PC4 and SFRS1-interacting protein;Hepatoma-derived growth factor;Hepatoma-derived growth factor-related protein 2;Hepatoma-derived growth factor-related protein 3 0 12465000.0 2861900.0 1524700.0 8078400.0 False True 2771050.551024858 2133520.6612054603 5962424.69319481 1.0 0.7699320607544995 2.1516838409857373 21.402001598818227 -6.864108222470995 1.16472090297325 0.8735189779991519 2.2240673068848387 0.9584458702141208 0.12322185125662925 0.14263411812486537 0.36535889717368236 0.08236255065210973 0.19324896148201143 1.3673880417307005e-07 6.864108222470995 1.3505483288856868 up GYPHWPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYPHWPAR 8 0 O75475-3;O75475-2;O75475;H3BPQ6;P51858;Q7Z4V5-2;Q7Z4V5;Q7Z4V5-4;Q7Z4V5-3;M0R0J3;Q9Y3E1 O75475-3;P51858;Q7Z4V5-2 PSIP1;HDGFRP3;HDGF;HDGFRP2 PC4 and SFRS1-interacting protein;Hepatoma-derived growth factor;Hepatoma-derived growth factor-related protein 2;Hepatoma-derived growth factor-related protein 3 0 9252200.0 2123700.0 3083200.0 4045300.0 False True 2908889.2808345617 2946974.02922104 3089883.4555686964 1.0 1.0130925396980224 1.0622210600886834 21.47203695444208 -6.946345192046476 0.5976361511766268 0.9994436357986554 1.0783746252323767 0.9988821996615727 0.000895467789105832 0.08498767499616872 0.042300229748114475 0.0009212108585712327 0.004125475615316959 1.1315006504653528e-07 6.946345192046476 0.07893098943372134 GYPHWPAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYPHWPAR 8 0 O75475-3;O75475-2;O75475;H3BPQ6;P51858;Q7Z4V5-2;Q7Z4V5;Q7Z4V5-4;Q7Z4V5-3;M0R0J3;Q9Y3E1 O75475-3;P51858;Q7Z4V5-2 PSIP1;HDGFRP3;HDGF;HDGFRP2 PC4 and SFRS1-interacting protein;Hepatoma-derived growth factor;Hepatoma-derived growth factor-related protein 2;Hepatoma-derived growth factor-related protein 3 0 5225800.0 2861900.0 1201600.0 1162300.0 False True 2379796.653666898 1195126.7423010734 1405331.556131997 1.0 0.5021970009326503 0.5905258980705762 21.182406874252504 -10.833925411135514 7.387616203215566 1.0269038622278435 0.5463614495016159 0.9723515807207627 0.03606012125511665 0.013996556224624425 0.000314644037961116 0.03058341775412674 0.011638354090273903 1.4657995663209537e-11 10.833925411135514 -0.48054241272622755 GYPHWPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYPHWPAR 8 0 O75475-3;O75475-2;O75475;H3BPQ6;P51858;Q7Z4V5-2;Q7Z4V5;Q7Z4V5-4;Q7Z4V5-3;M0R0J3;Q9Y3E1 O75475-3;P51858;Q7Z4V5-2 PSIP1;HDGFRP3;HDGF;HDGFRP2 PC4 and SFRS1-interacting protein;Hepatoma-derived growth factor;Hepatoma-derived growth factor-related protein 2;Hepatoma-derived growth factor-related protein 3 0 15082800.0 3349300.0 2480500.0 9253000.0 False True 4335734.874573266 2342457.994465255 7569048.943797555 1.0 0.540267812084752 1.745736112276127 22.0478451094955 -6.803360671910783 1.4422969794407752 0.7474168717908719 1.7637623489578633 0.8417668374530983 0.19759028450907315 0.21599734193311187 0.8867109386595274 0.10776119147808713 0.250101252874313 1.572676249326935e-07 6.803360671910783 1.0163454771669915 GYPTFHYYHYGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYPTFHYYHYGK 12 0 Q14554;H7C4F9 Q14554 PDIA5 Protein disulfide-isomerase A5 0 44287000.0 12352000.0 12595000.0 19340000.0 False True 16193591.616938166 10715875.09492546 17338882.322379783 1.0 0.6617355401081544 1.0707249344391065 23.94891966426104 -6.687077185333996 1.876946424080306 0.7873503689682553 1.0692584481900727 0.3567339222404142 0.1431481649438217 0.4229710679080096 2.8867313333950664 0.06106680928036793 0.15960206981396513 2.0555252436516054e-07 6.687077185333996 0.2819080792218174 GYPTFHYYHYGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYPTFHYYHYGK 12 0 Q14554;H7C4F9 Q14554 PDIA5 Protein disulfide-isomerase A5 0 30192400.0 5363900.0 4192500.0 20636000.0 False True 5193625.930550412 5866587.113598672 15230812.533269977 1.0 1.1295744422195881 2.9325971367475514 22.30831067737705 -6.921368790569732 0.8145098011878319 0.9621461065618648 3.2327070316761852 0.9945527763103752 0.06510230755163884 0.0973731303995479 0.10148973773220454 0.05650268328260002 0.17153213960623775 1.1984811546775975e-07 6.921368790569732 2.2705609251143204 up GYPTFHYYHYGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYPTFHYYHYGK 12 0 Q14554;H7C4F9 Q14554 PDIA5 Protein disulfide-isomerase A5 0 36472000.0 12352000.0 11154000.0 12966000.0 False True 16918868.200248856 10661179.398654483 9903697.843152216 1.0 0.6301354956177074 0.5853640873570103 24.012129725783932 -13.999999999999998 0.29786394187151183 4.3327018598223646 0.5741023953663886 0.9996450605636579 0.0035006194200172896 16.450559880287184 0.17326720835757914 33.74790572500609 0.016330133252499695 1.0000000000000041e-14 13.999999999999998 -3.758599464455976 GYPTFHYYHYGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYPTFHYYHYGK 12 0 Q14554;H7C4F9 Q14554 PDIA5 Protein disulfide-isomerase A5 0 19453100.0 5363900.0 7512000.0 6577200.0 False True 4460320.511060438 7471531.364984743 7952462.110463191 1.0 1.675110868480703 1.782935125568476 22.088715952811327 -11.288816891915788 0.3248431036631444 4.178554563099904e-23 1.8065838109212136 0.9993862101074016 0.008583776924212222 3.42705401559209 0.16772814844508507 2.4956908141974883 0.03515060312598734 5.142604293626027e-12 11.288816891915788 1.8065838109212136 GYPTFHYYHYGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYPTFHYYHYGK 12 0 Q14554;H7C4F9 Q14554 PDIA5 Protein disulfide-isomerase A5 0 20377100.0 2481300.0 7661800.0 10234000.0 False True 3212091.763735297 7235414.094736502 8371517.009707574 1.0 2.2525552278501966 2.606250887419372 21.615081677993473 -10.187363495577452 0.2920500514323574 4.614046855028143e-11 2.735263121982475 0.9989792334961047 0.02201714897478244 1.648940139980438 0.13542337545131378 1.4397499760185424 0.13052794980186622 6.495857727769037e-11 10.187363495577452 2.7352631219363346 GYPTLLLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYPTLLLFR 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 300317000.0 64157000.0 107330000.0 128830000.0 False True 84110448.29727177 91316782.36906315 115499907.42462173 1.0 1.0856770379622995 1.3731933399809035 26.32578168907227 -6.9489083888619465 0.5707111001290484 0.9964298213132926 1.4764362444109007 0.9991127422303431 0.0047542924665762735 0.08392724790064594 0.03780083793348748 0.005032807483633751 0.023959902481804646 1.1248422259074814e-07 6.9489083888619465 0.4800064230976081 GYPTLLLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYPTLLLFR 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 155352000.0 62665000.0 47924000.0 44763000.0 False True 95067386.42515756 39371587.76807898 35915573.42968012 1.0 0.4141440008879862 0.3777906891124528 26.50244716289525 -13.92746926877151 0.3957990142317658 9.999999999999998 0.3754178006513035 0.9998304856749702 0.0037123246089103773 24.620175549806387 0.20665830737312668 189.56863864664479 0.009415246234119944 1.1817639327012899e-14 13.92746926877151 -9.624582199348694 GYPTLLLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYPTLLLFR 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 346477000.0 64157000.0 133920000.0 148400000.0 False True 87877576.67773356 128002971.5857817 113350976.3939372 1.0 1.4566056145949131 1.2898737161314793 26.38899175059516 -10.023869836377013 5.845333109750057 0.9999992652099422 1.3732396653632597 0.8698178629769546 0.06806801251371652 6.517294556130128e-07 1.0887201742083877e-07 0.06590669934745472 0.021968856572888943 9.465208032752995e-11 10.023869836377013 0.3732404001533175 GYPTLLLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYPTLLLFR 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 147185600.0 2438600.0 73352000.0 71395000.0 False True 2027803.9482973197 72956838.216768 86323364.40681738 1.0 35.978250401389865 42.569876875572845 20.95148674607783 -9.019344956861499 0.6999477591900087 5.262236719137058e-16 41.62007552220455 0.9967560693833513 1.038990667700526 0.5221222322612724 0.3225044817683166 3.966300035108038 1.0462922533865398 9.564340810643506e-10 9.019344956861499 41.62007552220455 GYPTLLLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYPTLLLFR 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 234937000.0 62665000.0 130980000.0 41292000.0 False True 81121077.81182152 123690847.85932653 33777279.691698715 1.0 1.5247682993839788 0.41638105166764017 26.2735734849877 -6.777952744677146 1.5437945160894242 1.2979251922697572 0.40814944565197375 0.7601023032394971 0.22173430859881382 0.25376526882683514 1.194441263547701 0.11314113180273404 0.2674319263673763 1.6674286345932279e-07 6.777952744677146 -0.8897757466177835 down GYPTLLWFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYPTLLWFR 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 107764000.0 20449000.0 53659000.0 33656000.0 False True 26808837.028397713 45653286.36114374 30173599.971148543 1.0 1.7029193139853371 1.1255094705968278 24.67620530054974 -10.200722556354979 3.8879939563203183 0.9996792606043763 1.414214392428836 0.4069338804171372 0.2357265819350765 167032504.88898322 221113012.97180405 613991.387586182 0.08626711378421695 6.299084635593148e-11 10.200722556354979 0.41453513182445967 GYPTLLWFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYPTLLWFR 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 52454500.0 31111000.0 15532000.0 5811500.0 False True 30123398.33430044 21734008.598309997 4289293.808737085 1.0 0.7214992265186182 0.14239076750689908 24.844381199277244 -7.252890019428944 0.5550344387913311 1.0050090038170072 9.566633348081867e-25 0.9981240055774222 0.015471962546297081 0.09403509185079374 0.05266820647558429 0.01567157248734201 0.0548943169236566 5.586116394275889e-08 7.252890019428944 -1.0050090038170072 down GYPTLLWFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYPTLLWFR 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 94107000.0 19178000.0 17302000.0 57627000.0 False True 29094428.0996038 14214322.91885699 46236998.191188626 1.0 0.48855825143545467 1.5892045732226738 24.794239551958288 -6.780341183674789 1.5344400277078136 0.7105384050947361 1.5980325594624345 0.7686294021938651 0.21631530918263445 0.2500443980208663 1.162864070675286 0.11102893315324597 0.2619181317943684 1.6582836405817781e-07 6.780341183674789 0.8874941543676984 GYPTLLWFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYPTLLWFR 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 205005000.0 20449000.0 97748000.0 86808000.0 False True 28009547.91344631 93429170.15058973 66305738.26687931 1.0 3.3356186411612154 2.3672548543723004 24.73941536207263 -10.562647079530846 6.38578788051971 0.9970169136510755 2.851436747766753 0.8297562695095355 0.39533286050368727 0.016784396078684156 0.0011495358073189698 0.38265653338684946 0.12759313207827672 2.7374923895061697e-11 10.562647079530846 1.8544198341156775 GYPTLLWFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYPTLLWFR 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 102164000.0 31111000.0 29477000.0 41576000.0 False True 25870174.950987436 29318201.550273627 50269349.37429562 1.0 1.133281920428396 1.9431391349124563 24.62478647471152 -6.935568229085194 0.6995789621387284 0.9898501846632363 2.1357208805237273 0.9975238833403964 0.020737853501116364 0.08984777425170566 0.0642603163420451 0.019563878365032653 0.07116900206334482 1.1599299730360056e-07 6.935568229085194 1.145870695860491 GYPTLLWFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYPTLLWFR 9 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 139115000.0 19178000.0 67852000.0 52085000.0 False True 24826299.054896884 64075976.5532984 42606064.437230624 1.0 2.580971751432265 1.716166567679638 24.565365874050737 -10.068397303314772 5.406625560591616 0.999989448111409 2.148569159556828 0.701660595749114 0.3530552378543732 4.490591519771638e-05 7.738056865742673e-06 0.3418474010021637 0.11394808804132871 8.542848344395306e-11 10.068397303314772 1.1485797114454188 GYQYLLEPGDFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYQYLLEPGDFR 12 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 10652800.0 1879000.0 5381900.0 3391900.0 False True 2463387.1962618856 4578941.498481885 3040938.7254022686 1.0 1.8587989356404415 1.2344542222257222 21.232211978413016 -10.023403212228727 5.2990293337693055 0.9999963467924027 1.5466265789342908 0.5054519304144751 0.2548876619159416 1.1001065034322008e-05 2.027195315772082e-06 0.24679556446843923 0.08226463914557165 9.47538331337819e-11 10.023403212228727 0.5466302321418881 GYQYLLEPGDFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYQYLLEPGDFR 12 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 12315600.0 4117300.0 2583600.0 5614700.0 False True 3986598.5651960718 3615244.9532960127 4144041.632610533 1.0 0.9068495094685324 1.0394930828473616 21.926726908253887 -6.717975988199083 1.76661883757648 0.9432047218122332 1.0392623502941336 0.50286980253223 0.039208343490167136 0.35930059469673653 2.1903887754621536 0.017629941329515158 0.04436310714503002 1.9143617656540947e-07 6.717975988199083 0.09605762848190036 GYQYLLEPGDFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYQYLLEPGDFR 12 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 6984400.0 1879000.0 5105400.0 0.0 False True 2573717.078065706 4879826.546699892 0.0 1.0 1.8960229110992097 0.0 21.295422039935907 -6.785981270899426 1.5636219399565463 1.5081062754682057 1.1521478674900139e-18 0.7606372269452666 0.37889060081693865 0.2481102530341347 1.2065173798972006 0.19233611751398483 0.4421382382024388 1.6368871112316522e-07 6.785981270899426 -1.5081062754682057 GYSFSLTTFSPSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYSFSLTTFSPSGK 14 0 A0A024RA52;P25787;H3BT36 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 424860000.0 117420000.0 134260000.0 173180000.0 False True 153938757.0968976 114228931.34138095 155260994.8598618 1.0 0.7420414033191064 1.0085893753327624 27.197781263228283 -10.9985532972187 10.614618083359241 1.1203529267780001 0.8753153893259344 0.22585752867578923 0.10881775390118466 0.06394039292756584 8.714661006203811e-06 0.021736948154878307 0.0351207790525821 1.003336710725108e-11 10.9985532972187 -0.2450375374520657 GYSFSLTTFSPSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYSFSLTTFSPSGK 14 0 A0A024RA52;P25787;H3BT36 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 425478000.0 179980000.0 78078000.0 167420000.0 False True 174266633.4160713 109254952.5713912 123567679.50765929 1.0 0.6269413164741577 0.7090725119629445 27.376721124240582 -9.965744980641489 5.7053895889462884 1.000000417158617 0.6680069142183208 0.9561136941372537 0.03352992015287604 1.779355909153158e-07 3.222089976188648e-08 0.03246524670699541 0.010821735195859208 1.0820691598749348e-10 9.965744980641489 -0.33199350294029617 GYSFSLTTFSPSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYSFSLTTFSPSGK 14 0 A0A024RA52;P25787;H3BT36 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 557140000.0 161850000.0 163280000.0 232010000.0 False True 245538282.8199431 134141408.28753726 186153121.8064044 1.0 0.546315656959714 0.7581429651966463 27.87137273731978 -10.095417948290985 4.860538790964192 1.0000125874730024 0.6522293110774976 0.782317994870681 0.08647813647413696 1.3072183906907728e-05 2.4326943396816323e-06 0.08373545239986396 0.02791069852942303 8.027532115471691e-11 10.095417948290985 -0.34778327639550477 GYSFSLTTFSPSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYSFSLTTFSPSGK 14 0 A0A024RA52;P25787;H3BT36 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 426890000.0 117420000.0 114800000.0 194670000.0 False True 160833347.15618688 109727756.40716648 148692955.35449958 1.0 0.6822450589218214 0.9245157051298718 27.260991324751174 -9.789466835604062 5.593955707335047 1.0000000332628052 0.8033803833466042 0.4675738492511762 0.09890657715185262 4.096173516224984e-08 8.928532581313037e-09 0.09576589722869305 0.031921960510485986 1.6238023455365352e-10 9.789466835604062 -0.19661964991620096 GYSFSLTTFSPSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYSFSLTTFSPSGK 14 0 A0A024RA52;P25787;H3BT36 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 651300000.0 161850000.0 302850000.0 186600000.0 False True 209518015.54046592 285996131.2734546 152640714.6776855 1.0 1.3650192826412002 0.7285326480586332 27.64249905941223 -6.751179226840645 1.645532438922168 1.21433133009191 0.7271571380127936 0.6540064017352765 0.15339309662901845 0.2979941961910464 1.5879428858638582 0.07362788988047392 0.1785242170750934 1.7734574504722072e-07 6.751179226840645 -0.4871741920791165 GYSFTTTAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYSFTTTAER 10 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 1903460000.0 616580000.0 622820000.0 664060000.0 False True 808342350.9692142 529897683.73334545 595349441.3133148 1.0 0.6555362132121253 0.7365065564107611 29.59039119494755 -9.134518757744626 10.248165263884847 1.000000529092482 0.6960213875458146 0.9494745157002323 0.033056004190819985 0.0 0.0 0.032006338430032324 0.010668779476677439 7.336370269948158e-10 9.134518757744626 -0.3039791415466675 GYSFTTTAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYSFTTTAER 10 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 1443520000.0 406670000.0 126270000.0 910580000.0 False True 393760483.44990337 176690269.48935094 672071781.1855478 1.0 0.44872524520818396 1.706803525069963 28.552743093315893 -6.7876154208838955 1.5060166589188093 0.6909357047014784 1.7192894378077976 0.7934593127342142 0.23401206776479822 0.238921423309491 1.070588466082713 0.12232796851437079 0.2868843320817998 1.630739455866305e-07 6.7876154208838955 1.0283537331063193 GYSFTTTAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYSFTTTAER 10 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 1861680000.0 278440000.0 1406200000.0 177040000.0 False True 422413836.6906701 1155252623.3092532 142047966.4006113 1.0 2.7348834791016436 0.3362767837186919 28.65408185183993 -6.7126753303592634 1.7854866490002839 2.063663223152389 0.34142995169844903 0.4777815314501872 0.7307775873338047 0.3697771441291845 2.299511076115591 0.32549246486926187 0.8242885164848597 1.9378701345054615e-07 6.7126753303592634 -1.72223327145394 GYSFTTTAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYSFTTTAER 10 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 1403560000.0 616580000.0 302180000.0 484800000.0 False True 844546288.4479792 288828688.4243692 370300224.769412 1.0 0.34199272718982526 0.4384605436487227 29.65360125647044 -10.789971273601417 7.207368865106945 1.0186815947387216 0.39022663541927405 0.9815747808901131 0.0393828211541266 0.011115678396847998 0.0003239197025609058 0.035853292205402815 0.012710750871383118 1.621917375498683e-11 10.789971273601417 -0.6284549593194475 GYSFTTTAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYSFTTTAER 10 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 902250000.0 406670000.0 328540000.0 167040000.0 False True 338164123.5356641 326770089.8099157 201967291.69430342 1.0 0.966306201832949 0.597246359497397 28.33314836875017 -6.924753532632894 0.7886697881318152 1.0068347869663026 0.5306992222290619 0.9954026988599946 0.012369880771258042 0.09545507393433357 0.09170771133326056 0.010935665627561835 0.034407008111565766 1.1891769082412697e-07 6.924753532632894 -0.4761355647372407 GYSFTTTAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYSFTTTAER 10 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 842640000.0 278440000.0 349370000.0 214830000.0 False True 360446068.8729523 329927252.379088 175733144.34194607 1.0 0.9153304221369623 0.4875435176514225 28.42520817393238 -6.939572751555186 0.6635259563141246 1.0048388336138503 0.3736184553461492 0.9981074075054281 0.009757799903526128 0.0879620765528137 0.05550125053091627 0.009468018135932295 0.03688861217075675 1.1492837031416484e-07 6.939572751555186 -0.631220378267701 down GYSFYLAHEFFDVLPVHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYSFYLAHEFFDVLPVHK 18 0 Q7L592;C9J236;C9JS27 Q7L592 NDUFAF7 NADH dehydrogenase [ubiquinone] complex I, assembly factor 7 0 23943000.0 10232000.0 7228200.0 6482800.0 False True 13245525.702873327 6825944.315901538 5302996.919145221 1.0 0.5153396300775589 0.4003613777288471 23.65900176830997 -13.999999999999842 0.20210437912128595 3.715996395408504 0.32721866448102366 0.9994871409538398 0.005884584267146747 12.573310806998668 0.1425390223418566 13.511291845921994 0.0720799012843387 1.000000000000364e-14 13.999999999999842 -3.38877773092748 GYSLVSGGTDNHLVLVDLRPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYSLVSGGTDNHLVLVDLRPK 21 1 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 263450000.0 77433000.0 98894000.0 87123000.0 False True 101515412.86223872 84139400.68579282 78108347.70282798 1.0 0.8288337535500547 0.7694235338315054 26.597123544359658 -13.999999994584622 0.14758302529781647 1.8247350768677004 0.702208659174093 0.9995745036001992 0.0020163056727296636 11.949503002978041 0.12085904454389258 2.828372915438917 0.06044774217125025 1.0000000124693696e-14 13.999999994584622 -1.1225264176936074 GYSLVSGGTDNHLVLVDLRPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYSLVSGGTDNHLVLVDLRPK 21 1 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 381388000.0 126640000.0 81346000.0 173402000.0 False True 122619882.51923117 113827882.01378606 127982814.251506 1.0 0.9282987365114609 1.0437362328367403 26.869617686628533 -6.738704365194984 1.6914187902087023 0.957275396094589 1.0437856899636924 0.5991820250366826 0.030126709935493785 0.3201347253551662 1.7978141545243853 0.014093586967809392 0.03463399339501564 1.8251376951151287e-07 6.738704365194984 0.08651029386910336 GYSLVSGGTDNHLVLVDLRPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYSLVSGGTDNHLVLVDLRPK 21 1 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 589976000.0 129468000.0 234632000.0 225876000.0 False True 196412421.37863722 192760086.41181663 181231509.5950324 1.0 0.9814047658432979 0.9227090034477016 27.549310929559542 -6.950303266527388 0.5555167405769674 1.0007864466963345 0.9005437217258326 0.9992247520363573 0.0009171149482487614 0.08336446554711523 0.03546197645133516 0.0009885048857609358 0.004874584269549152 1.1212352256929375e-07 6.950303266527388 -0.1002427249705019 GYSLVSGGTDNHLVLVDLRPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYSLVSGGTDNHLVLVDLRPK 21 1 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 494474000.0 77433000.0 216651000.0 200390000.0 False True 106062072.64814357 207078642.45094958 153062009.1615974 1.0 1.9524287738362816 1.4431361309463953 26.66033360588255 -10.252772473243292 5.379698524438353 0.9999333416448853 1.6977824523913927 0.7145224974318358 0.20791785080583522 0.00016624696571712914 2.3091602227726993e-05 0.20133468435320925 0.06710519779582186 5.5876285376980494e-11 10.252772473243292 0.6978491107465074 GYSLVSGGTDNHLVLVDLRPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYSLVSGGTDNHLVLVDLRPK 21 1 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 315206000.0 126640000.0 95915000.0 92651000.0 False True 105306771.10324462 95398286.85736312 112023895.73017775 1.0 0.9059083842180761 1.0637862556848081 26.65002296206281 -6.745260907332872 1.667273245120522 0.944359825357975 1.0639920854383336 0.628371198646227 0.03953221152817426 0.30838754446648897 1.6850670847495415 0.018742326444454366 0.0457319736600618 1.7977905475897558e-07 6.745260907332872 0.11963226008035854 GYSLVSGGTDNHLVLVDLRPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYSLVSGGTDNHLVLVDLRPK 21 1 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 477910000.0 129468000.0 204636000.0 143806000.0 False True 167598878.1958176 193247826.71049878 117634783.5741653 1.0 1.1530377099822453 0.701882881559173 27.32043725165199 -6.815177940436006 1.3925639557198788 1.0829105744646563 0.6930129187361596 0.8729355770771086 0.066776073851243 0.19982626123548347 0.7626866361630639 0.03769329481653226 0.08701007970483458 1.5304602684375506e-07 6.815177940436006 -0.3898976557284968 GYSSLLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYSSLLKR 8 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 11270800.0 4206300.0 4169000.0 2895500.0 True False 5514500.03386715 3547001.450634724 2595901.4355972414 1.0 0.6432136057395798 0.47074103176255044 22.394798660697067 -13.99999999999978 0.09588312699153617 2.785406639723178 0.07876961583248376 0.999814145909055 0.003004577480147321 12.112990048453861 0.09135652524225206 4.327283531527618 0.35050824986211687 1.0000000000005072e-14 13.99999999999978 -2.7066370238906945 GYSSLLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYSSLLKR 8 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 20650200.0 5768800.0 6336700.0 8544700.0 True False 5585672.601681472 8866977.355453948 6306586.734494664 1.0 1.5874502477615131 1.1290648744067406 22.413299583369355 -10.766399285117947 6.216986533284554 0.9873554649184927 1.3582575610841245 0.44887081747299695 0.18713504504572545 0.032878431815777286 0.0012353921878839075 0.1816402745409286 0.06039757607948913 1.7123822399552157e-11 10.766399285117947 0.37090209616563186 GYSSLLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYSSLLKR 8 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 27332300.0 4856700.0 4217600.0 18258000.0 True False 7367968.972330038 3464936.3277407903 14649298.297234332 1.0 0.47027021160826665 1.9882410406787658 22.812835555351707 -6.812457966072188 1.4044157033005589 0.712135163624703 2.016254399242061 0.8660891640067413 0.23019782554296128 0.20347085123673367 0.7905300304558662 0.12887315718964243 0.2977584226968209 1.5400755776723762e-07 6.812457966072188 1.304119235617358 GYSSLLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYSSLLKR 8 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 9885600.0 4206300.0 2978700.0 2700600.0 True False 5761482.780983387 2847091.184756333 2062773.9006028764 1.0 0.4941594539089091 0.35802830261184887 22.458008722219958 -13.999999999999998 0.18422169746666375 3.6596952288488755 0.25447795633749243 0.9994936498046334 0.006214913332444081 12.262299081799128 0.1360932620823763 11.686420396058002 0.09810794837409091 1.0000000000000041e-14 13.999999999999998 -3.405217272511383 GYSSLLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYSSLLKR 8 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 19996800.0 5768800.0 10010000.0 4218000.0 True False 4797012.801171811 9956074.14317057 5099964.298171517 1.0 2.07547374915041 1.0631541981555066 22.19370485880363 -6.631965370384748 2.073705268511938 1.7075501132507909 1.0672930244558458 0.12442124888746264 0.46109893350374365 0.5539525204682805 4.542298934885231 0.18171854005225674 0.5106257413715596 2.3336441341286235e-07 6.631965370384748 -0.640257088794945 GYSSLLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYSSLLKR 8 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 25313700.0 4856700.0 6119000.0 14338000.0 True False 6287093.889869509 5778472.270966702 11728631.1203036 1.0 0.9191006802487304 1.8655091407497704 22.583961877444157 -6.886113641991311 1.0451260953576929 0.9443101886758544 1.9409635045105016 0.9782909303577825 0.06311281721560072 0.1223518979873674 0.2407350827572331 0.04623189265505644 0.11375398769220796 1.2998294067063937e-07 6.886113641991311 0.9966533158346472 GYSWYK(ub)GQPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYSWYKGQPK 10 1 Q9NUD5;Q9NUD5-2 Q9NUD5 ZCCHC3 Zinc finger CCHC domain-containing protein 3 1 5809300.0 2354300.0 3455000.0 0.0 True False 3086510.0990736303 2939527.467484521 0.0 1.0 0.9523790213311715 0.0 21.557545081196857 -7.063414669433667 1.0338497507591116 1.0087057994068789 2.833868875429458e-20 0.9884789881797249 0.04943794466262112 0.08461538679594749 0.17350073379634484 0.03985901582614638 0.07107673521979524 8.641424314795245e-08 7.063414669433667 -1.0087057994068789 down GYSWYK(ub)GQPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYSWYKGQPK 10 1 Q9NUD5;Q9NUD5-2 Q9NUD5 ZCCHC3 Zinc finger CCHC domain-containing protein 3 1 2316200.0 2316200.0 0.0 0.0 True False 2242673.4988237824 0.0 0.0 1.0 0.0 0.0 21.0967881692782 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 GYSWYK(ub)GQPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYSWYKGQPK 10 1 Q9NUD5;Q9NUD5-2 Q9NUD5 ZCCHC3 Zinc finger CCHC domain-containing protein 3 1 6896300.0 2316200.0 4580100.0 0.0 True False 1926022.9250579253 4555426.0922213355 0.0 1.0 2.365198270983369 0.0 20.877193444712475 -6.752315751559981 1.6552692172012993 1.8024571250904404 4.520194834759093e-11 0.649716144633157 0.5737475288207053 0.29798987522792386 1.609508579752101 0.27441358195152604 0.6609567882429687 1.768822477463009e-07 6.752315751559981 -1.8024571250452386 GYTAK(ub)ELNVSFINEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYTAKELNVSFINEK 15 1 C9J050;C9JEJ2;P49585;Q9Y5K3-2;Q9Y5K3-4;Q9Y5K3-3;Q9Y5K3 C9J050 PCYT1A;PCYT1B Choline-phosphate cytidylyltransferase A;Choline-phosphate cytidylyltransferase B 1 9173200.0 2785000.0 3535300.0 2852900.0 True False 2315850.89641927 3516254.6371978945 3449428.199680777 1.0 1.5183424125597502 1.4894863071772992 21.14311093926566 -10.105721983285532 4.791540699111934 0.9999738555734313 1.5039143598733813 0.9975466667069326 0.011780455708566643 3.2904091334213225e-06 6.14093867995522e-07 0.011406968065085564 0.0038021257284566517 7.839313214069972e-11 10.105721983285532 0.50394050429995 GYTLVEYETYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYTLVEYETYK 11 0 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 29619300.0 6614000.0 9369300.0 13636000.0 False True 8671018.050067104 7971436.961245349 12225077.525748208 1.0 0.9193196133623154 1.4098779930060923 23.047769957184073 -6.8646897363394235 1.1619101221988535 0.9555556435491274 1.435840233480301 0.9590847175292402 0.043443779993739745 0.1420429761299325 0.36177643917329655 0.02910317323169736 0.06833114353090482 1.3655583546635692e-07 6.8646897363394235 0.48028458993117373 GYTLVEYETYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 GYTLVEYETYK 11 0 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 21512300.0 5600500.0 3273800.0 12638000.0 False True 5422715.193058711 4581045.412641466 9327728.668126864 1.0 0.8447881272660944 1.7201214402826697 22.370583969743347 -6.861091846375167 1.1802943256911191 0.915540973630932 1.7633842765976206 0.9549491011047526 0.08094301904797607 0.14567583083033858 0.3850197357617169 0.053466422247523404 0.12495653849706001 1.3769182417927834e-07 6.861091846375167 0.8478433029666886 GYTLVEYETYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYTLVEYETYK 11 0 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 27530000.0 6614000.0 10124000.0 10792000.0 False True 9059374.536629353 9676688.204409003 8243151.8682167865 1.0 1.068140870573757 0.909902977836674 23.110980018706965 -6.789665511320916 1.4975251462436399 1.0381002813528444 0.9082320862768692 0.8002861028134695 0.028961970420710855 0.23584829678710884 1.0448631677933766 0.015222593567197903 0.03565073240157688 1.6230596782269934e-07 6.789665511320916 -0.12986819507597513 GYVGSIQPHGVFFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYVGSIQPHGVFFR 14 0 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 0 5751300.0 2104900.0 0.0 3646400.0 False True 2759544.2838805974 0.0 3269105.5067386506 1.0 0.0 1.184654120549747 21.395998606737205 -10.758850208250882 6.19664707490715 1.0130614602601822 0.5923270602748735 0.13636681295497033 0.48363301950540527 0.08704336611813458 0.003387390560295502 0.4670582304103725 0.15609188585170344 1.7424077405657325e-11 10.758850208250882 -0.4207343999853087 GYVK(ub)EQFAWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYVKEQFAWR 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 89880900.0 9943900.0 43315000.0 36622000.0 True False 15085623.296467295 35585099.828360334 29383645.648007214 1.0 2.3588750115942205 1.947791289133422 23.84667097011911 -10.080982294043483 4.749224198779381 0.9999501880425976 2.153333150381763 0.9130066206582075 0.16782422699377988 58300100.01948655 3.076030377484434 31757.15751707605 0.05745069675345151 8.298846007813422e-11 10.080982294043483 1.1533829623391654 GYVK(ub)EQFAWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYVKEQFAWR 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 14717400.0 3128400.0 3158700.0 8430300.0 True False 4285054.021831156 3019138.189575933 6439236.76747849 1.0 0.7045741253655766 1.50272009049883 22.0308819618852 -6.806495966142964 1.4292589237097126 0.8383171884427041 1.51558571050016 0.8504705734630102 0.12740851531996222 0.21161701179791037 0.8526372997974825 0.07010779141318897 0.16244279176832008 1.5613635403138324e-07 6.806495966142964 0.6772685220574559 GYVK(ub)EQFAWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYVKEQFAWR 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 122443900.0 9943900.0 61310000.0 51190000.0 True False 12872574.5735733 57898044.604178585 41873945.25375522 1.0 4.497782807414465 3.2529580632393587 23.61779729221156 -9.775269320078634 10.450362824430142 1.0000000014047972 3.875370435325192 0.8767552427006102 0.5081975737366028 0.0 0.0 0.49206018491621956 0.16402006163873983 1.677763260097755e-10 9.775269320078634 2.875370433920395 GYWAGLDASAQTTSHELTIPNDLIGCIIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYWAGLDASAQTTSHELTIPNDLIGCIIGR 30 0 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;F8VRH0 Q15366-3;Q15366-4 PCBP2 Poly(rC)-binding protein 2 0 327720000.0 123380000.0 100210000.0 104130000.0 False True 187176480.2862192 82326742.55569641 83548659.85819958 1.0 0.4398348683007995 0.4463630245127054 27.47982392315377 -9.898763991155082 6.880756274934727 1.0000000147381005 0.44309894640734815 0.9998969510566968 0.0026651086134112075 6.021038678169455e-10 1.0059051216439436e-10 0.0025804803957893358 0.0008601601062950575 1.262513436446343e-10 9.898763991155082 -0.5569010683307524 GYWASLDASTQTTHELTIPNNLIGCIIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 GYWASLDASTQTTHELTIPNNLIGCIIGR 29 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 896058000.0 315288000.0 269810000.0 310960000.0 False True 478314946.64031035 221660297.46484825 249498619.7013905 1.0 0.46341913214670105 0.521619952405568 28.833385633230847 -10.101339908976636 5.748109135243605 1.0000034659551575 0.4925195422788437 0.9902317291704478 0.02376038537444983 1.0553698070063423e-06 1.6496519576475382e-07 0.02300605117365096 0.007668631404534343 7.918813066536252e-11 10.101339908976636 -0.5074839236763138 GYWASLDASTQTTHELTIPNNLIGCIIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYWASLDASTQTTHELTIPNNLIGCIIGR 29 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 515545000.0 315288000.0 38177000.0 162080000.0 False True 408146531.2556221 36052416.389719844 132583103.0812393 1.0 0.0883320416292849 0.3248419205557391 28.604511955323296 -10.260101355179764 5.189375874303284 1.0001147847860308 0.20658698256000738 0.9375199039650485 0.09655475375014547 0.00012824481547178183 1.828499187686027e-05 0.09350208557274439 0.03116291277253552 5.494126375630853e-11 10.260101355179764 -0.7935278022260234 GYWGNK(ub)IGKPHTVPCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 GYWGNKIGKPHTVPCK 16 2 P15880;H0YEN5;E9PMM9;E9PPT0;I3L404;E9PM36 P15880 RPS2 40S ribosomal protein S2 1 25606800.0 3722300.0 6515500.0 15369000.0 True False 4818590.727502484 6152906.6974152 12571999.699256955 1.0 1.2769100023990423 2.6090615306880665 22.200179838657455 -6.940669361091101 0.6533055624258756 0.9852022970405573 2.975487820877348 0.9982502796419607 0.02938146283624588 0.0874625631723102 0.053228744556018344 0.02874785473694525 0.11432166395103766 1.1463853802576439e-07 6.940669361091101 1.990285523836791 up GYYNGTK(ub)FHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 GYYNGTKFHR 10 1 Q9Y3C6 Q9Y3C6 PPIL1 Peptidyl-prolyl cis-trans isomerase-like 1 1 2781340.0 676890.0 1305200.0 799250.0 True False 562864.0263113965 1298168.6285380835 966369.4796855344 1.0 2.3063627587738043 1.7168790942608654 19.10242692026095 -10.020487941388465 5.3577652213568285 0.9999942849351771 2.011620926519096 0.797025522409732 0.2406556982999557 1.6428813939514613e-05 3.003164739059152e-06 0.23301519268477253 0.077671292639578 9.539202290030374e-11 10.020487941388465 1.0116266415839188 GYYSPYSVSGSGSTAGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 7457400.0 1508900.0 3399600.0 2548900.0 False True 1978182.5122083868 2892392.931537013 2285164.2787752757 1.0 1.4621466491016684 1.1551837429925427 20.91574410831845 -10.434101311764973 5.491395259699053 0.9997590570137748 1.3086651960471072 0.5741351078705911 0.1253170816548753 0.000369950689395194 3.812401734484177e-05 0.1214313232741735 0.04044591418705314 3.6804310691433816e-11 10.434101311764973 0.3089061390333324 GYYSPYSVSGSGSTAGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 GYYSPYSVSGSGSTAGSR 18 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 4436360.0 1508900.0 972460.0 1955000.0 False True 2066781.1064892726 929493.501704818 1493269.264488863 1.0 0.4497300167813598 0.7225096357811193 20.97895416984134 -10.097813868831063 5.426655935589107 1.0000052604255796 0.5861198262810466 0.7542680752154831 0.1113618131307334 7.087538583032417e-06 1.1784302079257e-06 0.10782698198480777 0.03594187063813172 7.983367674088759e-11 10.097813868831063 -0.41388543414453294 HAAENPGK(ub)YNILGTNTIMDK ddPTM_RPMI8226_Bortezomib_1h_R1 2 HAAENPGKYNILGTNTIMDK 20 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 195004700.0 58844700.0 84818200.0 51341800.0 True False 77145971.55288549 72163655.17875408 46029443.041321516 1.0 0.9354170247150766 0.5966538772509616 26.201087487599715 -6.938742775475725 0.6711625774591939 1.003897857370379 0.5085841222347931 0.9979944730176918 0.007921807157482393 0.08834507406328367 0.057257949778286146 0.007639684955007196 0.02932190106383151 1.1514821884469404e-07 6.938742775475725 -0.49531373513558585 HAAENPGK(ub)YNILGTNTIMDK ddPTM_RPMI8226_Bortezomib_2h_R1 2 HAAENPGKYNILGTNTIMDK 20 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 265804100.0 100877400.0 91330900.0 73595800.0 True False 97675102.15449704 127799804.65435162 54318852.15332582 1.0 1.3084174148311103 0.5561176897200197 26.541487523478526 -6.795394606437346 1.4747045688858307 1.1711746829082719 0.5468837401803737 0.81832798092418 0.13161144631495023 0.2274042934174976 0.976776236577433 0.07022687639424205 0.16379668503709593 1.601789319643433e-07 6.795394606437346 -0.6242909427278982 HAAENPGK(ub)YNILGTNTIMDK ddPTM_RPMI8226_Bortezomib_8h_R1 2 HAAENPGKYNILGTNTIMDK 20 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 400764500.0 150179400.0 146299100.0 104286000.0 True False 227833129.384797 120190882.56491436 83673826.38982248 1.0 0.5275390935877411 0.36725925951050875 27.763402304757694 -13.999999999999998 0.1509309632298156 3.287882229880701 0.19279319806840914 0.9995631618917301 0.00561372803143631 11.961365256112291 0.12240040850881813 8.023734730168597 0.15739744164751973 1.0000000000000041e-14 13.999999999999998 -3.0950890318122917 HAAENPGK(ub)YNILGTNTIMDK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 HAAENPGKYNILGTNTIMDK 20 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 185897000.0 58844700.0 77527400.0 49524900.0 True False 80601175.8082241 74101983.1191722 37828138.61733225 1.0 0.9193660312783085 0.4693248980304885 26.264297549122606 -6.9373846796562955 0.6834597044896235 1.0053525595680186 0.3567635326561477 0.9978009096578359 0.010949349051146594 0.08898025039347922 0.06019614005878934 0.010457939765802336 0.039201286582638724 1.1550886603280295e-07 6.9373846796562955 -0.6485890269118709 down HAAENPGK(ub)YNILGTNTIMDK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 HAAENPGKYNILGTNTIMDK 20 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 235981300.0 100877400.0 109108700.0 25995200.0 True False 83884027.72655132 108520909.7767187 31430676.13177532 1.0 1.2937017060086782 0.3746920240195709 26.321892798912803 -6.820729176830352 1.3687713435448894 1.1581857863163625 0.3543222098701605 0.8860432606266364 0.129371843356998 0.19253385594507583 0.7086024538499887 0.07427112046301834 0.17114593199985437 1.5110221238441002e-07 6.820729176830352 -0.803863576446202 down HAAENPGK(ub)YNILGTNTIMDK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 HAAENPGKYNILGTNTIMDK 20 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 323108800.0 150179400.0 127316000.0 45613400.0 True False 194410193.77854726 120230752.68024142 37312229.23300717 1.0 0.6184385208586147 0.19192527154985273 27.534528626850143 -7.544251040582771 0.38978324594348057 1.0432234237146907 3.2254874010739623e-22 0.9989152947974707 0.010870651477655726 0.12086113761391819 0.04948206659702599 0.02131755288116333 0.06872877972865846 2.855939212469978e-08 7.544251040582771 -1.0432234237146907 down HAALQDIGK(ub)NIYTIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HAALQDIGKNIYTIR 15 1 Q9ULX3;H3BUR4 Q9ULX3 NOB1 RNA-binding protein NOB1 1 5809780.0 920480.0 2845700.0 2043600.0 True False 1206758.1939410008 2421132.6524517224 1832147.8755954118 1.0 2.0063113427428636 1.5182394325511301 20.202705192102474 -10.166417169823989 4.7408979766293 0.9999157250938573 1.7622753876503945 0.7648349319483351 0.19925452297653137 0.00017934903227970675 3.153453965318702e-05 0.19294874277169524 0.0643091207595884 6.81683575426063e-11 10.166417169823989 0.7623596625565372 HAALQDIGK(ub)NIYTIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HAALQDIGKNIYTIR 15 1 Q9ULX3;H3BUR4 Q9ULX3 NOB1 RNA-binding protein NOB1 1 6420480.0 920480.0 1983200.0 3516800.0 True False 1260806.3310366794 1895575.6664346035 2686204.2707695332 1.0 1.5034629980609269 2.1305447193946443 20.265915253625366 -6.968162179381494 0.2988424314593859 0.8897360399891527 2.763888461076221 0.9999642883827775 0.00276362829354305 0.07690367936367135 0.011153333356842784 0.010463680819790667 0.05630952127977077 1.0760633023071578e-07 6.968162179381494 1.8741524210870681 HAALQDIGK(ub)NIYTIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HAALQDIGKNIYTIR 15 1 Q9ULX3;H3BUR4 Q9ULX3 NOB1 RNA-binding protein NOB1 1 8134000.0 1631100.0 4030900.0 2472000.0 True False 1356331.9199818564 4009184.7416289924 2988883.7707633986 1.0 2.955902373574326 2.203652164142374 20.37127884567016 -10.38197327027817 5.785393201443661 0.9995801750744931 2.579777268858353 0.8546593136335806 0.30710486200168813 0.0016633795217838611 0.00017768975331789534 0.2974226159326962 0.09911766800598715 4.149795827872572e-11 10.38197327027817 1.5801970937838599 HAALQDIGK(ub)NIYTIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HAALQDIGKNIYTIR 15 1 Q9ULX3;H3BUR4 Q9ULX3 NOB1 RNA-binding protein NOB1 1 25605400.0 2399900.0 4164500.0 19041000.0 True False 3106717.859101417 3932741.9141102834 15575733.377158672 1.0 1.265883190064702 5.0135654679835575 21.56695979637847 -6.921203608487853 0.8157549540501181 0.9208426107195805 5.634957551589886 0.9945086865055877 0.1357990086342886 0.09746872598253012 0.10198393042899448 0.1177566152225575 0.35689728431610906 1.1989370786492824e-07 6.921203608487853 4.714114940870306 up HAASTVQILGAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HAASTVQILGAEK 13 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 6431400.0 1635700.0 2440200.0 2355500.0 False True 2144418.540141333 2076131.6718250983 2111775.455551477 1.0 0.9681559979836147 0.9847776523198198 21.032155082795313 -10.186359788521564 4.220164990316635 1.0000086693110646 0.9764668251500157 0.7277210961115852 0.006785761973138199 9527729.406848624 0.013035866516746155 802.6390770820182 0.0023229468132550542 6.510887801826322e-11 10.186359788521564 -0.023541844161048875 HAASTVQILGAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HAASTVQILGAEK 13 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 16519700.0 3042800.0 10222000.0 3254900.0 False True 4616150.058477133 8397804.235149471 2611567.58832665 1.0 1.8192225401615099 0.5657458174546878 22.13825869215983 -6.730358859032874 1.721832735042577 1.4928126433411955 0.5664361247938376 0.560930388941144 0.34437334745027537 0.3355855213528774 1.9492748612048847 0.15848109671881008 0.393113777617671 1.8605491231402572e-07 6.730358859032874 -0.9263765185473578 HAASTVQILGAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HAASTVQILGAEK 13 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 6690400.0 1635700.0 2252300.0 2802400.0 False True 2240462.4931304273 2152785.9386399062 2140530.8372396883 1.0 0.9608667608766718 0.9553968628365155 21.095365144318205 -13.99999763462333 0.27721336156361265 1.3140890852053484 0.9537044585416496 0.9995989443687399 0.00039773755132874536 15.249389193989552 0.16674758842729825 2.710950712386089 0.0021927438138020683 1.0000054464958909e-14 13.99999763462333 -0.36038462666369875 HAASTVQILGAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HAASTVQILGAEK 13 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 9090800.0 3042800.0 2875400.0 3172600.0 False True 3938964.5825550235 2715381.4623202607 2595219.3536249986 1.0 0.6893642746487756 0.6588582606502139 21.90938501425228 -13.999999999999998 0.32810922597371156 4.343224478451719 0.6533353359347054 0.9997109027123114 0.0026206344899441154 18.664671164347208 0.1830678435789178 43.018795521193795 0.009845197108569615 1.0000000000000041e-14 13.999999999999998 -3.689889142517014 HAASTVQILGAEK(ub)ALFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HAASTVQILGAEKALFR 17 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 1 4553500.0 1378700.0 1929900.0 1244900.0 True False 1807489.0513497905 1641966.4426912807 1116089.6899240215 1.0 0.9084240048176772 0.6174807471672107 20.785555477573208 -6.950154613081359 0.5571421829118753 1.003863598598853 0.5082045107492537 0.9992133699177638 0.004573882846441673 0.08342369166750273 0.03570567717591041 0.004920039132102491 0.024170539409307475 1.1216190758585538e-07 6.950154613081359 -0.49565908784959944 HAASTVQILGAEK(ub)ALFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HAASTVQILGAEKALFR 17 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 1 15152400.0 4192600.0 2123900.0 8835900.0 True False 5427403.348501436 2005703.0979418515 7227856.863990144 1.0 0.3695511406012688 1.331733869749303 22.371830698800387 -6.729912312520788 1.7233558104660351 0.6205678382488039 1.3311736015454683 0.5589533913478877 0.26502745222103036 0.3363983441076159 1.9572302516127917 0.12186617164795928 0.30245505999215216 1.8624631446918332e-07 6.729912312520788 0.7106057632966644 HACSSIIK(ub)MCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HACSSIIKMCR 11 1 Q9HAV4 Q9HAV4 XPO5 Exportin-5 1 2601350.0 685270.0 1079300.0 836780.0 True False 898395.6061641204 918272.6470784481 750198.032560545 1.0 1.0221250424400412 0.8350419652692487 19.776991346319654 -6.877399800155132 1.0942361975936044 1.0132923937725775 0.8224292121250478 0.971525087045149 0.01408465699486838 0.12995649684842625 0.2864380502893667 0.009937684320238676 0.023880185284480063 1.3261730553487896e-07 6.877399800155132 -0.1908631816475297 HACSSIIK(ub)MCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HACSSIIKMCR 11 1 Q9HAV4 Q9HAV4 XPO5 Exportin-5 1 2379900.0 685270.0 735560.0 959070.0 True False 938632.8377254317 703060.5270283566 732557.4186666672 1.0 0.7490261354291287 0.7804515133327932 19.840201407842546 -10.027565191798647 7.164855985188112 1.0000000253626367 0.7647388244740608 0.9867946886062671 0.012829356806352164 5.205522612676594e-09 6.975366398845553e-10 0.012421972609099032 0.004140657104462857 9.385011480062679e-11 10.027565191798647 -0.23526120088857583 HACSSIIK(ub)MCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HACSSIIKMCR 11 1 Q9HAV4 Q9HAV4 XPO5 Exportin-5 1 5305600.0 0.0 1507100.0 3798500.0 True False 0.0 1423228.5601526264 3107211.97590133 0.0 HADHSSLTLGSGSSTTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HADHSSLTLGSGSSTTR 17 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 2408830.0 691860.0 877360.0 839610.0 False True 907035.1599817703 746461.3079224942 752735.2113078219 1.0 0.8229684370090975 0.8298853721645701 19.790798950381546 -9.983245963310736 4.919451816973356 1.0000016927805573 0.8264269045839673 0.9988103787296312 0.002823826964959882 3885810.6478431546 0.5529336418802941 76.07390664357531 0.0009666710776089879 1.0393313722802033e-10 9.983245963310736 -0.17357478819659 HADHSSLTLGSGSSTTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HADHSSLTLGSGSSTTR 17 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 2306580.0 691860.0 650470.0 964250.0 False True 947659.3388134845 621730.0845833591 736514.0093521156 1.0 0.6560691792071561 0.7771927940627555 19.854009011904438 -10.383273834422463 5.107852847655344 1.0002005422378764 0.7166309866349335 0.8794846260938534 0.04944850869967946 0.0001130066467591139 1.3644571106251695e-05 0.047911927148651695 0.015959437557376447 4.1373871910075994e-11 10.383273834422463 -0.28356955560294284 HADIVTTTTHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HADIVTTTTHK 11 0 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 33574500.0 6100500.0 15943000.0 11531000.0 False True 7997814.577326045 13564366.545327276 10337882.733162414 1.0 1.6960091302669744 1.292588448158139 22.93117440317625 -10.145246863311948 4.434027772761756 0.9999225066541388 1.4942987892323227 0.6668567381442199 0.16469580387799634 87049827.68314776 11.317351723838115 71247.73783374095 0.0602724926209805 7.157364529401968e-11 10.145246863311948 0.4943762825781839 HADIVTTTTHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HADIVTTTTHK 11 0 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 18029700.0 6076300.0 4520400.0 7433000.0 False True 5883411.1824984625 6325419.29357459 5486074.3147797845 1.0 1.075127863303347 0.9324648821247363 22.488221436821636 -6.763644187018183 1.5989941090534043 1.04344072372779 0.9318520989945582 0.7055775428677274 0.03161739318951141 0.27683662920576413 1.3958270622795537 0.015596234045519205 0.03734297422043551 1.7232798621664057e-07 6.763644187018183 -0.11158862473323183 HADIVTTTTHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HADIVTTTTHK 11 0 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 24040500.0 3177300.0 16330000.0 4533200.0 False True 4820196.391744242 13415783.913127646 3637211.0330278594 1.0 2.7832442545505898 0.754577352752155 22.20066049744402 -6.674538608707252 1.9211357254580153 2.133740175293217 0.7625607632467776 0.2994134890660951 0.7566954039782242 0.4507522818183314 3.211431252541853 0.31660203047839697 0.8409525452735274 2.115735588338057e-07 6.674538608707252 -1.3711794120464393 HADIVTTTTHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HADIVTTTTHK 11 0 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 33254500.0 6100500.0 12642000.0 14512000.0 False True 8356019.709813648 12083434.638496509 11084564.484021664 1.0 1.446075411275686 1.3265364215217805 22.99438446469914 -9.967182046848741 4.946125552178122 0.9999970728567501 1.3863059163424474 0.9329964656311165 0.04880158824020399 33523405.715791587 5.194866186911179 1148.9696866808436 0.01670608169632034 1.0784945458900178e-10 9.967182046848741 0.3863088434856973 HADIVTTTTHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HADIVTTTTHK 11 0 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 12809700.0 6076300.0 4107700.0 2625700.0 False True 5052712.67573157 4085571.004785384 3174721.730134889 1.0 0.8085896165061165 0.6283202576277956 22.268626712255912 -6.97185082996512 0.2093321870983985 1.095189342890812 0.3366919925399342 0.9999934414632651 0.00038860988618085265 0.0757067388253761 0.006838626332740916 0.005426970824478223 0.018709234091857617 1.0669625350684623e-07 6.97185082996512 -0.7584973503508777 HADIVTTTTHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HADIVTTTTHK 11 0 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 8440700.0 3177300.0 2366800.0 2896600.0 False True 4113077.4839463867 2235085.499415591 2369448.521625848 1.0 0.5434095292732212 0.5760768015856648 21.97178681953647 -10.347202079934968 6.91069927266884 1.0000135648625839 0.559743165429443 0.9958876957022494 0.013336358075672582 2.7873341982229896e-06 2.6330263682971315e-07 0.012913270403805315 0.004304291060511557 4.495706182008932e-11 10.347202079934968 -0.44027039943314084 HADIVTTTTHK(ub)TLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HADIVTTTTHKTLR 14 1 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 1 10276170.0 931870.0 1766700.0 7577600.0 True False 902288.2969298481 2472152.5232187873 5592799.236872781 1.0 2.73986987488434 6.198461462819588 19.783228947935566 -6.960163916316111 0.43311786303866934 0.8670771710751427 8.204570425922787 0.9997762295939119 0.032320043292123166 0.07964262265369657 0.0209153752350142 0.04524067207011067 0.2869683992591355 1.0960644290787262e-07 6.960163916316111 7.337493254847645 HADIVTTTTHK(ub)TLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HADIVTTTTHKTLR 14 1 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 1 41952400.0 1793100.0 6203300.0 33956000.0 True False 2720263.7931692307 5096272.648395879 27244581.716556486 1.0 1.8734479579491408 10.01541901376238 21.375315130595283 -6.927368498317738 0.7680899632952035 0.8633527974078486 11.58014160902645 0.9959952262546456 0.2569127903785521 0.09402739613168 0.08454556920092918 0.23049528501569494 0.7476510757581071 1.18203817220881e-07 6.927368498317738 10.716788811618601 up HADIVTTTTHK(ub)TLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HADIVTTTTHKTLR 14 1 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 1 22971100.0 1793100.0 3466000.0 17712000.0 True False 2321203.2972851987 3273114.053141131 14488597.74046713 1.0 1.4100936600293714 6.241847819797821 21.146441452687732 -6.923659074794473 0.797111452726504 0.9067851706354971 7.090613701283809 0.9951386176972115 0.16596074293734442 0.09606630028646126 0.09480412857957891 0.14583686942558022 0.4533832470133373 1.192177511218859e-07 6.923659074794473 6.183828530648312 up HADYLNDDQK(ub)VR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HADYLNDDQKVR 12 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;E7ERV5 G3V394 MYO5A Unconventional myosin-Va 1 10722010.0 1965800.0 3166400.0 5589810.0 True False 2544766.8517111368 2990187.0565107036 4572521.936294061 1.0 1.1750337971040687 1.796833345742237 21.279102053802674 -6.947603633444501 0.5845707913304163 0.9926876817873524 2.0101765317461697 0.9989994769031992 0.010815446773762291 0.08446271230028289 0.040058156945839946 0.011276507982987422 0.0520085977538471 1.1282266825095264e-07 6.947603633444501 1.0174888499588173 HAEK(ub)APTNIVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HAEKAPTNIVYK 12 1 P15927;P15927-2;P15927-3;Q5TEJ7 P15927 RPA2 Replication protein A 32 kDa subunit 1 6215500.0 1070400.0 2246300.0 2898800.0 True False 1466155.8064723401 2147051.0384792527 2214163.1426600055 1.0 1.464408508973673 1.5101827056071322 20.483606994269948 -11.766744653757902 0.37603347877736076 4.212956591185678e-18 1.515040423159623 0.9996438449210975 0.004349484068210738 4.701874849414676 0.1927530669374695 3.7555551458409635 0.012545537511027537 1.7110210252533476e-12 11.766744653757902 1.515040423159623 HAEMVHTGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HAEMVHTGLK 10 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 20463600.0 3778400.0 9368900.0 7316300.0 False True 4953518.990077647 7971096.639686159 6559279.4589052275 1.0 1.6091785770182765 1.3241656026844886 22.24002235225616 -10.028092005401827 4.456775894135273 0.9999790182540121 1.4666720898251293 0.7814038857884773 0.11635605970689508 40208614.34508733 0.8083967386194004 8974.098578508374 0.039831774101386296 9.373634052023007e-11 10.028092005401827 0.46669307157111717 HAEMVHTGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HAEMVHTGLK 10 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 12507500.0 3982600.0 2681000.0 5843900.0 False True 3856174.5429650196 3751537.281230301 4313207.276757922 1.0 0.9728650089437438 1.118519721734766 21.878738923426035 -6.858565174659206 1.1929484042370848 0.9853296876293481 1.1253825551342103 0.9518702327693636 0.013874839200212817 0.14829217652335863 0.4018295589867131 0.009076387658652901 0.02115417687772754 1.3849523302569503e-07 6.858565174659206 0.14005286750486212 HAEYSVILQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HAEYSVILQEK 11 0 Q8WUB8-3;Q8WUB8-2;Q8WUB8;S5FZ81 Q8WUB8-3 PHF10 PHD finger protein 10 0 4723000.0 1551400.0 1449600.0 1722000.0 False True 1502151.6561934238 2028432.8395641327 1270956.5411073314 1.0 1.350351564837567 0.8460906965466057 20.51859904302401 -6.719853132626637 1.759897674815964 1.2131830175310785 0.8468859964738096 0.5118077643814524 0.14743176553867268 0.355599070791371 2.1523821250876543 0.0665197455374597 0.16701488750128413 1.9061052053946487e-07 6.719853132626637 -0.3662970210572689 HAEYSVILQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HAEYSVILQEK 11 0 Q8WUB8-3;Q8WUB8-2;Q8WUB8;S5FZ81 Q8WUB8-3 PHF10 PHD finger protein 10 0 5264300.0 1470600.0 2587500.0 1206200.0 False True 2014320.561470689 2473175.6942817345 921320.4024687805 1.0 1.2277964796606295 0.45738519483518014 20.941861863216484 -6.827505438169224 1.3390272386237407 1.121945444045618 0.4376918410968647 0.900789654039686 0.10178594097509104 0.18391106407919447 0.645781519755297 0.059698733359666245 0.13740497100823154 1.487628746102745e-07 6.827505438169224 -0.6842536029487534 down HAEYSVILQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HAEYSVILQEK 11 0 Q8WUB8-3;Q8WUB8-2;Q8WUB8;S5FZ81 Q8WUB8-3 PHF10 PHD finger protein 10 0 3701800.0 2255100.0 0.0 1446700.0 False True 2919271.404666697 0.0 1183415.444395539 1.0 0.0 0.4053804118739187 21.47717691375968 -10.71516889925572 6.706413894608681 1.0098046444052695 0.20269020593696632 0.8376052528146022 0.16549586013506398 0.024008340523716056 0.0010196676661297166 0.158570986936493 0.05341355918078124 1.9267754350383672e-11 10.71516889925572 -0.8071144384683032 HAEYSVILQEK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 HAEYSVILQEKER 13 1 Q8WUB8-3;Q8WUB8-2;Q8WUB8;S5FZ81 Q8WUB8-3 PHF10 PHD finger protein 10 1 6635900.0 2345800.0 1353700.0 2936400.0 True False 2271333.8630259987 1894239.4694522412 2167268.749888251 1.0 0.8339766778841702 0.9541832599637703 21.115108352484985 -10.301860069783523 5.181407729373933 1.0000255640387448 0.894079968934018 0.5086559525508112 0.04907413163655195 1.4495637959807786e-05 1.953128551855118e-06 0.04752728778112384 0.015838607879822324 4.9904525455404634e-11 10.301860069783523 -0.10594559510472679 HAEYSVILQEK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HAEYSVILQEKER 13 1 Q8WUB8-3;Q8WUB8-2;Q8WUB8;S5FZ81 Q8WUB8-3 PHF10 PHD finger protein 10 1 6625200.0 2310500.0 2846800.0 1467900.0 True False 3164754.288914744 2721018.962891302 1121212.2523494635 1.0 0.859788379913814 0.35428098044665235 21.593662062682384 -6.947263479131986 0.5881207601197335 1.0058764268744709 0.1828385174961103 0.9989686556666798 0.00890595783549695 0.08460357925435659 0.04065621351563262 0.009251108878915964 0.04232529397897956 1.1291106944372766e-07 6.947263479131986 -0.8230379093783606 down HAEYSVILQEK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HAEYSVILQEKER 13 1 Q8WUB8-3;Q8WUB8-2;Q8WUB8;S5FZ81 Q8WUB8-3 PHF10 PHD finger protein 10 1 6399900.0 2345800.0 2749000.0 1305100.0 True False 1950636.636560259 2734190.591366224 1577990.3758993973 1.0 1.401691396603562 0.8089617237385719 20.89551362791926 -6.724206263482777 1.744446038370071 1.2432805137917091 0.8096754067732368 0.532209640620686 0.1689513869498622 0.34718797833159226 2.0670055855467235 0.07684007206220266 0.19193022335462945 1.8870948808571356e-07 6.724206263482777 -0.4336051070184723 HAFGCALVHTSGWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HAFGCALVHTSGWK 14 0 G5E9D5;Q9BQ52-4;Q9BQ52;E7ES68;Q9BQ52-3 G5E9D5 ELAC2 Zinc phosphodiesterase ELAC protein 2 0 16217900.0 4967300.0 5574400.0 5676200.0 False True 6512178.403401628 4742721.248841009 5088881.273955114 1.0 0.7282849079140177 0.7814407036663712 22.6347087926042 -10.658952286204677 6.634775629905359 1.001338548620488 0.7548628057901952 0.9659362402836795 0.021700762744144595 0.0004318380246942939 2.2197766246460997e-05 0.021117586001948862 0.007003891059005865 2.1930458612610186e-11 10.658952286204677 -0.24647574283029283 HAFGCALVHTSGWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HAFGCALVHTSGWK 14 0 G5E9D5;Q9BQ52-4;Q9BQ52;E7ES68;Q9BQ52-3 G5E9D5 ELAC2 Zinc phosphodiesterase ELAC protein 2 0 14269500.0 4967300.0 5583500.0 3718700.0 False True 6803845.046235112 5336802.507834615 2840419.6490305564 1.0 0.7843803719174527 0.417472712815865 22.697918854127092 -6.9630767278683185 0.3896534657710515 1.022621315900971 0.16605572059922008 0.9998678458196385 0.002764446656897925 0.07861980608711386 0.01719991902628339 0.004738127193339232 0.03086816316775057 1.088737726384001e-07 6.9630767278683185 -0.8565655953017508 down HAFGCALVHTSGWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HAFGCALVHTSGWK 14 0 G5E9D5;Q9BQ52-4;Q9BQ52;E7ES68;Q9BQ52-3 G5E9D5 ELAC2 Zinc phosphodiesterase ELAC protein 2 0 25032100.0 4293900.0 9599200.0 11139000.0 False True 5558538.195422969 9064996.08162503 9111816.29579173 1.0 1.6308237459066774 1.6392468622945893 22.40627409696759 -11.279930887990961 0.6977950363081743 3.1844738489825317e-10 1.6377796052521914 0.9999803133029393 0.0013283196309276308 4.031388458943287 0.3570396489848672 6.249560769761182 0.0013162032715715048 5.248909828031947e-12 11.279930887990961 1.6377796049337439 HAFSLK(ub)QLDNPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HAFSLKQLDNPAR 13 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 41412000.0 13306000.0 13636000.0 14470000.0 True False 17444294.855487287 11601561.952711685 12972783.206041114 1.0 0.6650633945838339 0.7436691086404326 24.056251945375095 -10.38863014492331 6.456312239421451 1.000033385611228 0.7043662516121344 0.9496471825527215 0.0320906483842977 1.5423148701653832e-05 1.4604839811482293e-06 0.031075137908313115 0.010357212230115237 4.0866726853730254e-11 10.38863014492331 -0.2956671339990936 HAFSLK(ub)QLDNPAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HAFSLKQLDNPAR 13 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 70925000.0 22753000.0 17459000.0 30713000.0 True False 22030718.469362516 24430469.747482244 22668343.92975001 1.0 1.1089275087172936 1.028942563143105 24.393013209422115 -10.506421899299488 4.64821757151676 0.9996499084685366 1.0689350359302179 0.49758358720800633 0.032653717293570875 0.00011906850611844947 1.2643407406337267e-05 0.03177698799981941 0.01053894193913814 3.115861181842275e-11 10.506421899299488 0.06928512746168125 HAFSLK(ub)QLDNPAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HAFSLKQLDNPAR 13 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 47025000.0 11365000.0 14035000.0 21625000.0 True False 17241535.89279366 11530344.594044492 17350809.271425802 1.0 0.6687539129773097 1.0063377984021606 24.039384961041094 -10.97258223154867 10.32427835005055 1.084656853307598 0.8375458556897352 0.2359245589255432 0.137818044112844 0.08141302680980228 0.00021620513271284 0.04045350124015443 0.044480582471327024 1.0651671603492766e-11 10.97258223154867 -0.24711099761786282 HAFSLK(ub)QLDNPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HAFSLKQLDNPAR 13 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 34878900.0 13306000.0 12097000.0 9475900.0 True False 18225587.781129453 11562514.540570483 7237887.5822864575 1.0 0.6344110642369607 0.39712780016787586 24.119462006897987 -8.443466371585567 0.16041605367408193 1.388551459167523 4.414809299023371e-08 0.9998798028107445 0.0027186280861294034 0.1309281383946119 0.038408460171468574 0.15477210896806518 0.1387178580965523 3.6019163977692932e-09 8.443466371585567 -1.38855141501943 down HAFSLK(ub)QLDNPAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HAFSLKQLDNPAR 13 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 63876100.0 22753000.0 32940000.0 8183100.0 True False 18920127.628807064 32762545.68192195 9894148.375620535 1.0 1.73162392583647 0.5229430038598726 24.17341848485639 -6.742851866109045 1.6765145382346969 1.4338684837598046 0.5218184553521894 0.6176043482819791 0.3073829762094993 0.3126616142194347 1.7266234875335829 0.14499099125608758 0.35465145932281433 1.8077906417782697e-07 6.742851866109045 -0.9120500284076152 HAFSLK(ub)QLDNPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HAFSLKQLDNPAR 13 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 40973000.0 11365000.0 16241000.0 13367000.0 True False 14712216.537642235 15337174.073013617 10934343.157002257 1.0 1.0424788157360507 0.743215213630521 23.810511283133543 -6.870926496503825 1.1291185585719647 1.0241670265790208 0.7253725689825201 0.9656024007404982 0.024519371970891334 0.13597293781005182 0.3234207161626506 0.016842623357768007 0.03994294296141818 1.3460881575797117e-07 6.870926496503825 -0.2987944575965007 HAGLLDGLARR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HAGLLDGLARR 11 1 Q6ZMJ2-3;Q6ZMJ2-2;Q6ZMJ2 Q6ZMJ2-3 SCARA5 Scavenger receptor class A member 5 0 5524300.0 1439100.0 1159700.0 2925500.0 False True 1886674.0362642254 986677.2804751947 2622797.3233775613 1.0 0.5229717807687115 1.3901698295328866 20.847413757028242 -6.7573421935257265 1.622296918723619 0.7220065717090711 1.3929494030904606 0.6801097694097202 0.2005709738718473 0.28739702247808663 1.4901022686635044 0.09757409464985081 0.23512204471896073 1.748468475467396e-07 6.7573421935257265 0.6709428313813894 HAGLLDGLARR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HAGLLDGLARR 11 1 Q6ZMJ2-3;Q6ZMJ2-2;Q6ZMJ2 Q6ZMJ2-3 SCARA5 Scavenger receptor class A member 5 0 3848400.0 1439100.0 1407800.0 1001500.0 False True 1971174.1602151978 1345598.741027952 764966.3265399477 1.0 0.6826381799166086 0.3880764784662328 20.910623818551134 -7.21900795993804 0.2301309201196758 1.1346816225464909 9.880911933550907e-12 0.9999742375024344 0.001268269266749103 0.09368285675185148 0.011888218467497238 0.013189851642302589 0.039821793384948796 6.039375600448236e-08 7.21900795993804 -1.1346816225366099 down HAGPIVSVWHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HAGPIVSVWHR 11 0 Q9NQG5;E9PIQ9;E9PQF3 Q9NQG5 RPRD1B Regulation of nuclear pre-mRNA domain-containing protein 1B 0 25283000.0 7761200.0 10593000.0 6928800.0 False True 10175008.359567702 9012565.691190597 6211874.241742761 1.0 0.8857551141681329 0.6105031094054728 23.278526643990716 -6.9562487257278365 0.48542537095080796 1.0062810492551806 0.47839542962100473 0.9996047686256455 0.003249992978828181 0.08106942930150352 0.02629757160054325 0.00392468546014722 0.022702795308064988 1.1059901885388282e-07 6.9562487257278365 -0.5278856196341759 HAGPIVSVWHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HAGPIVSVWHR 11 0 Q9NQG5;E9PIQ9;E9PQF3 Q9NQG5 RPRD1B Regulation of nuclear pre-mRNA domain-containing protein 1B 0 16086100.0 4795300.0 2371300.0 8919500.0 False True 4643075.826314515 3318172.45616614 6583215.370735688 1.0 0.7146496375011756 1.41785652808543 22.146649411149415 -6.796536063367731 1.4699413358019326 0.8418624340204452 1.426762154640996 0.8218676774021705 0.12188038075439606 0.22573613338273701 0.9632550867807668 0.06523961885888492 0.1520594875121604 1.5975848617443324e-07 6.796536063367731 0.5848997206205508 HAGPIVSVWHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HAGPIVSVWHR 11 0 Q9NQG5;E9PIQ9;E9PQF3 Q9NQG5 RPRD1B Regulation of nuclear pre-mRNA domain-containing protein 1B 0 15584800.0 5330400.0 6713200.0 3541200.0 False True 8086606.504438827 5515177.009529002 2841280.267836899 1.0 0.6820137725882496 0.35135631569030706 22.947102980716657 -7.183322123407117 0.26969213453063273 1.093237336747273 4.985330755385141e-12 0.9999565046758797 0.0017465342312718737 0.08758472452395137 0.01331711788097753 0.010143465694081592 0.03780470189104798 6.556587729385804e-08 7.183322123407117 -1.0932373367422876 down HAGPIVSVWHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HAGPIVSVWHR 11 0 Q9NQG5;E9PIQ9;E9PQF3 Q9NQG5 RPRD1B Regulation of nuclear pre-mRNA domain-containing protein 1B 0 21630700.0 7761200.0 5822600.0 8046900.0 False True 10630725.37854365 5565338.279236648 6146387.951107644 1.0 0.523514443376494 0.5781720185823918 23.341736705513608 -10.143037924708125 5.00513353669319 1.0000230774768406 0.5508432309784497 0.9890157771314267 0.022313861642152506 5.746475873845361e-06 9.839179814136478e-07 0.02160641215566143 0.007201767876976487 7.193861549600084e-11 10.143037924708125 -0.44917984649839093 HAGPIVSVWHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HAGPIVSVWHR 11 0 Q9NQG5;E9PIQ9;E9PQF3 Q9NQG5 RPRD1B Regulation of nuclear pre-mRNA domain-containing protein 1B 0 12929400.0 4795300.0 5581000.0 2553100.0 False True 3987504.4178094575 5550934.045258239 3086941.4057993647 1.0 1.39208223079729 0.7741537268302717 21.92705468658369 -6.735270916970953 1.704004853310089 1.2345637171373778 0.7741547934377462 0.583458990916097 0.1647660734426087 0.3264775116419754 1.859412050147621 0.07655321526227891 0.1888391254284662 1.8396240687131228e-07 6.735270916970953 -0.4604089236996316 HAIPIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HAIPIIK 7 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-3;C9J081;C9J8G5;A0A2R8Y4D2;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 12197100.0 3554800.0 5295300.0 3347000.0 False True 4660377.224732165 4505261.880917735 3000684.5466910605 1.0 0.9667161398456657 0.6438716013731081 22.15201530493858 -6.9266983641551745 0.7734135121183064 1.005557016965808 0.5828419352543511 0.9958485742414607 0.010348433476150729 0.09438888406090534 0.0863473886591743 0.009248932047127905 0.029759812660124656 1.1838635134188528e-07 6.9266983641551745 -0.4227150817114568 HAIPIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HAIPIIK 7 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-3;C9J081;C9J8G5;A0A2R8Y4D2;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 12526800.0 3554800.0 3926200.0 5045800.0 False True 4869105.62485788 3752727.5017928327 3854085.9615129903 1.0 0.7707221389148582 0.7915387872953533 22.21522536646147 -10.748816354615364 6.8715876714769255 1.0041129637098603 0.7811304631051098 0.9932613026054897 0.00849836111452448 0.0005432564240875422 1.9858133719170155e-05 0.008347889266120527 0.0027428342555508396 1.7831326219501114e-11 10.748816354615364 -0.22298250060475044 HAIPIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HAIPIIK 7 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-3;C9J081;C9J8G5;A0A2R8Y4D2;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 18888800.0 6960300.0 6234900.0 5693600.0 False True 9010245.558024736 5887922.3340824125 4657423.221269397 1.0 0.6534696858332003 0.5169030290324759 23.103134993955337 -13.999999999999998 0.1286315265240231 2.6466212800257516 0.3222848867434392 0.9996518545159305 0.003794006122743504 11.939047835146615 0.11139490219298223 4.976678125991751 0.17299682792664073 1.0000000000000041e-14 13.999999999999998 -2.3243363932823122 HAIVICNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HAIVICNR 8 0 P53621;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 17882400.0 6576500.0 4971800.0 6334100.0 False True 8621855.186916586 4230026.819924613 5678708.092977545 1.0 0.4906167788973719 0.6586410894020603 23.039566900470618 -10.631008125100033 7.407718479431249 1.0007859230297096 0.5746289341497164 0.89523706127946 0.06859563751990837 0.0008918388356038276 4.4424049606202264e-05 0.06652818177422919 0.0221391468114238 2.3387934823843978e-11 10.631008125100033 -0.4261569888799932 HAIVICNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HAIVICNR 8 0 P53621;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 13709900.0 6576500.0 3069700.0 4063700.0 False True 9008009.773229957 2934070.5038595754 3103937.754528588 1.0 0.3257179529910213 0.3445753093821994 23.10277696199351 -10.216122199430552 8.387860149532298 1.0000001768758469 0.3351466312480294 0.9993970109515001 0.007698483509366253 2.5474013776346477e-08 2.3703529389383663e-09 0.0074540266049445865 0.0024846748685689963 6.079639116150646e-11 10.216122199430552 -0.6648535456278175 HALDAHQQSIPAVLEIPSK(ub)EHPYDAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HALDAHQQSIPAVLEIPSKEHPYDAAK 27 1 Q16864;Q16864-2 Q16864 ATP6V1F V-type proton ATPase subunit F 1 31053400.0 6046600.0 4848800.0 20158000.0 True False 7927151.155357691 4125377.9404743607 18072243.529189818 1.0 0.5204111615414522 2.279790453721247 22.918371055370223 -6.83407229180816 1.3095702667224238 0.744365835508169 2.3312097256188613 0.9137790356660372 0.21805686826128642 0.1758433452662374 0.5883226291967676 0.13067604087210882 0.3007509630916483 1.4653039090378298e-07 6.83407229180816 1.5868438901106923 up HALDAHQQSIPAVLEIPSK(ub)EHPYDAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HALDAHQQSIPAVLEIPSKEHPYDAAK 27 1 Q16864;Q16864-2 Q16864 ATP6V1F V-type proton ATPase subunit F 1 78976800.0 5383600.0 9438200.0 64155000.0 True False 5212700.564833652 13206922.479562776 47350880.89125491 1.0 2.5336046671585932 9.083752328053773 22.313599558351346 -6.9433707892544705 0.6274202014203896 0.9285357450891933 11.040281305091487 0.9985729237202634 0.13243007806715795 0.08626193553479032 0.04785548189955803 0.13247859553744712 0.5559324395549697 1.1392766876184396e-07 6.9433707892544705 10.111745560002293 HALDAHQQSIPAVLEIPSK(ub)EHPYDAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HALDAHQQSIPAVLEIPSKEHPYDAAK 27 1 Q16864;Q16864-2 Q16864 ATP6V1F V-type proton ATPase subunit F 1 279278000.0 12237000.0 83531000.0 183510000.0 True False 18564423.64453285 68624240.41931818 147239168.06470957 1.0 3.6965457012465754 7.931254472749061 24.14603718984956 -6.964483549233994 0.3668077977444546 0.6623315663907408 11.11213631945995 0.9999021006142791 0.028226815109111493 0.07813665604095006 0.015480545171854532 0.05610248652458331 0.36027925186490456 1.0852166560891155e-07 6.964483549233994 10.449804753069209 HALDAHQQSIPAVLEIPSK(ub)EHPYDAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HALDAHQQSIPAVLEIPSKEHPYDAAK 27 1 Q16864;Q16864-2 Q16864 ATP6V1F V-type proton ATPase subunit F 1 37190700.0 6046600.0 6463100.0 24681000.0 True False 8282191.4232209055 6177538.871386393 18851856.121150717 1.0 0.7458821652040466 2.276191790049127 22.981581116893114 -6.8642344765117915 1.1640877902066007 0.8602331795090185 2.3565442291246734 0.9585865005858549 0.1362624721272301 0.1425068894065782 0.36456431268388884 0.0911238304133392 0.2138400018376355 1.366990585209064e-07 6.8642344765117915 1.496311049615655 up HALDAHQQSIPAVLEIPSK(ub)EHPYDAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HALDAHQQSIPAVLEIPSKEHPYDAAK 27 1 Q16864;Q16864-2 Q16864 ATP6V1F V-type proton ATPase subunit F 1 51918600.0 5383600.0 11946000.0 34589000.0 True False 4476701.933918417 11881644.526904663 41821399.97853363 1.0 2.6541066844056704 9.342011283276957 22.094004833785622 -6.944627748957039 0.615004482906028 0.9264834578139081 11.420924240744931 0.9987093740014872 0.12955994658021983 0.08571739228348173 0.04546189379636073 0.13107813182630887 0.5649525443571165 1.1359840955638808e-07 6.944627748957039 10.494440782931022 HALDAHQQSIPAVLEIPSK(ub)EHPYDAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HALDAHQQSIPAVLEIPSKEHPYDAAK 27 1 Q16864;Q16864-2 Q16864 ATP6V1F V-type proton ATPase subunit F 1 309553000.0 12237000.0 66806000.0 230510000.0 True False 15841037.72733197 63088187.37280636 188559545.2323327 1.0 3.982579200853403 11.903231876469427 23.91716351194201 -6.954155029622518 0.5112006510177595 0.8556542739802211 15.378358080904379 0.9994882894770407 0.1040766265703796 0.0818590104823662 0.02938048517123996 0.11962896332671985 0.6537638140883657 1.1113349444560515e-07 6.954155029622518 14.522703806924158 HALHCTILASAGQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HALHCTILASAGQQR 15 0 D6RFN0;Q9BT78;D6RAX7;D6RD63;Q9BT78-2 D6RFN0 COPS4 COP9 signalosome complex subunit 4 0 14803500.0 2562600.0 6860500.0 5380400.0 False True 3359593.416253699 5836940.142019553 4823687.820441163 1.0 1.7373948031272062 1.4357951164876623 21.679855215468894 -10.111453834436157 4.530507861830802 0.9999587021124322 1.586594959625167 0.8345398338914415 0.12312755680566208 19090551.93931674 21376988.66054375 8595.021375544111 0.04214983711997565 7.73652913816429e-11 10.111453834436157 0.5866362575127347 HALHCTILASAGQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HALHCTILASAGQQR 15 0 D6RFN0;Q9BT78;D6RAX7;D6RD63;Q9BT78-2 D6RFN0 COPS4 COP9 signalosome complex subunit 4 0 10492500.0 2562600.0 5539300.0 2390600.0 False True 3510062.47166108 5294555.409984477 1825989.5159524693 1.0 1.5083934980447553 0.5202156744202758 21.743065276991786 -6.766871379976143 1.5865024922211957 1.2927644636165534 0.5153118960444618 0.7184302060026502 0.21409827641921475 0.2715156073185218 1.3482335348439736 0.10640356748806576 0.25401109995836146 1.7105218257458158e-07 6.766871379976143 -0.7774525675720916 HALHCTILASAGQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HALHCTILASAGQQR 15 0 D6RFN0;Q9BT78;D6RAX7;D6RD63;Q9BT78-2 D6RFN0 COPS4 COP9 signalosome complex subunit 4 0 10565300.0 2992400.0 4458400.0 3114500.0 False True 3873720.78902249 4210286.12075142 2547692.957468655 1.0 1.0868842516173862 0.6576862650215815 21.88528854009306 -6.854006008924703 1.2155472665646665 1.0465767609567496 0.639150166004473 0.945941840596226 0.043076992064112106 0.15310433796441528 0.4333061607984072 0.027698707131582546 0.06428497463571353 1.3995679579317895e-07 6.854006008924703 -0.4074265949522765 HALIIYDDLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HALIIYDDLSK 11 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 167559000.0 43244000.0 64106000.0 60209000.0 False True 56693302.77549175 54541634.683230855 53979150.24551006 1.0 0.9620472262697128 0.9521256939160897 25.756674982743128 -13.999999999998359 0.18834676801391 1.2023013184971318 0.9448882670943398 0.9994903244210954 0.00046573297805597714 12.324258604707932 0.13762403745209845 0.9145138046625338 0.006913948468730851 1.0000000000037794e-14 13.999999999998359 -0.257413051402792 HALIIYDDLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HALIIYDDLSK 11 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 108232000.0 34287000.0 19892000.0 54053000.0 False True 33198577.9527549 27834979.335409626 39894897.7447588 1.0 0.8384389046730181 1.2017050188575389 24.984618109866656 -6.785799836345089 1.5129730384923716 0.9092061151396478 1.2051384392125817 0.7874368728014263 0.06851337684848749 0.24168417410281595 1.0929457205494097 0.03565202475431282 0.08373616862304853 1.6375710939683327e-07 6.785799836345089 0.2959323240729339 HALIIYDDLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HALIIYDDLSK 11 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 234672000.0 51085000.0 123430000.0 60157000.0 False True 77499679.81375837 101402952.13700831 48266942.5822502 1.0 1.3084305945610686 0.6228018321913307 26.20768701418477 -6.784402104435075 1.518599365310502 1.1736425867503038 0.6165898820987185 0.7826968159853449 0.1306993362272855 0.24379319988733036 1.1106873891177897 0.06776745484227924 0.15933274984839102 1.6428499374572462e-07 6.784402104435075 -0.5570527046515853 HALIIYDDLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HALIIYDDLSK 11 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 153155000.0 43244000.0 53784000.0 56127000.0 False True 59232475.425158806 51407645.040096186 42870958.571849875 1.0 0.8678962793822551 0.7237745554973137 25.81988504426602 -6.97000955004834 0.25796243769780264 1.0414822556825583 0.5459240571779164 0.9999824531447964 0.00047248960134579557 0.07629964942651898 0.009019274667379878 0.0030486365875910235 0.01364008366286157 1.0714957430025831e-07 6.97000955004834 -0.4955581985046419 HALIIYDDLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HALIIYDDLSK 11 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 94673000.0 34287000.0 40049000.0 20337000.0 False True 28511159.671643626 39833248.0878959 24589372.672336247 1.0 1.3971107645794183 0.8624472997775718 24.765023385300932 -6.70781686102425 1.8028806442253562 1.244684214372452 0.8637798165181313 0.45467260232206375 0.16739988746512846 0.3795350754931908 2.4033508502116208 0.07392643035041845 0.18831421899522754 1.9596708789311116e-07 6.70781686102425 -0.3809043978543206 HALIIYDDLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HALIIYDDLSK 11 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 179529000.0 51085000.0 67832000.0 60612000.0 False True 66130539.53589559 64057089.57087987 49581237.931639135 1.0 0.9686461054216825 0.7497479724133581 25.97881333627722 -6.93271986569593 0.7241159179772436 1.0030160877443328 0.7015292979463414 0.9970463507296812 0.006049857857257512 0.09124996960739744 0.07093991101895694 0.0056037399363026135 0.019518742178199287 1.1675624906414568e-07 6.93271986569593 -0.3014867897979914 HALIVQGFSFLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HALIVQGFSFLNR 13 0 Q9Y5Q9 Q9Y5Q9 GTF3C3 General transcription factor 3C polypeptide 3 0 3052280.0 931700.0 1266400.0 854180.0 False True 1221467.7225956356 1077458.0563885367 765797.647473131 1.0 0.8821011283858763 0.6269487382325589 20.220184310075094 -6.9584730070736365 0.4564444283793819 1.0077072459563745 0.49111802254296116 0.9997093064396079 0.002654563198183211 0.08025115757338576 0.023181270276970235 0.0034448143315010354 0.021086859248385 1.100340233177973e-07 6.9584730070736365 -0.5165892234134133 HALIVQGFSFLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HALIVQGFSFLNR 13 0 Q9Y5Q9 Q9Y5Q9 GTF3C3 General transcription factor 3C polypeptide 3 0 6295200.0 1592000.0 1709300.0 2993900.0 False True 2415180.390789924 1404262.060178144 2402154.3527270122 1.0 0.5814315425602048 0.9946065982845068 21.20369951787953 -10.90338236994347 10.459594101119388 1.020687860916343 0.7880190704227082 0.2597885166975483 0.16867801016175765 0.07158353117798151 0.0006612321254655382 0.14367006923309758 0.054440593685657734 1.2491587374341222e-11 10.90338236994347 -0.23266879049363476 HALIVQGFSFLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HALIVQGFSFLNR 13 0 Q9Y5Q9 Q9Y5Q9 GTF3C3 General transcription factor 3C polypeptide 3 0 2657200.0 931700.0 0.0 1725500.0 False True 1276174.668245779 0.0 1317972.4377879964 1.0 0.0 1.032752389294541 20.283394371597986 -10.473749986197275 5.006393631371538 1.0011217419261167 0.5163761946472475 0.22623941244223889 0.4216193974020479 0.005290212450901236 0.0005560832497689865 0.40910905494029876 0.1360770753813332 3.359309466630554e-11 10.473749986197275 -0.4847455472788692 HANAK(ub)PFEVPFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HANAKPFEVPFLK 13 1 A6NFX8;Q9UKK9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 1 11423000.0 3926600.0 4218700.0 3277700.0 True False 3801952.2323121754 5903248.910229869 2419172.041107722 1.0 1.55268886864467 0.6362973265543873 21.8583089754192 -6.74343703686685 1.6743677705522897 1.3275407453119281 0.6353761115597 0.6201399149350492 0.23220635598217756 0.3116449072482292 1.7168142439077507 0.10966089286326608 0.2680628910149537 1.8053564550766735e-07 6.74343703686685 -0.6921646337522281 HANAK(ub)PFEVPFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HANAKPFEVPFLK 13 1 A6NFX8;Q9UKK9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 1 17512000.0 3694600.0 6789900.0 7027500.0 True False 5604978.311439991 5578189.295269164 5638511.5447373325 1.0 0.9952204960158099 1.0059827587965682 22.418277359832395 HANAK(ub)PFEVPFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HANAKPFEVPFLK 13 1 A6NFX8;Q9UKK9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 1 12200600.0 3926600.0 5862400.0 2411600.0 True False 3265141.877874297 5830818.08760471 2915854.410021438 1.0 1.7857778637786923 0.8930253321548601 21.638714250853475 -6.674283515280694 1.922017765166572 1.4997032344270242 0.8965474693942262 0.29816938978842944 0.33345639759937146 0.4513946726801383 3.218720865288254 0.13946473354747876 0.37056913574010186 2.1169786821382848e-07 6.674283515280694 -0.603155765032798 HANAKPFEVPFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HANAKPFEVPFLK 13 1 A6NFX8;Q9UKK9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 13207300.0 3007700.0 5082900.0 5116700.0 False True 3943123.8266082313 4324551.132989015 4587272.966852146 1.0 1.0967322668912676 1.1633601095398505 21.910907585686363 -6.975095246935316 0.06010401403577303 0.6488784992102665 1.6128719304160846 0.999999961545984 1.1816801144847919e-05 0.07468068938755153 0.0017274028354635753 0.011366904763653976 0.016274225800011494 1.0590214412946223e-07 6.975095246935316 0.963993431205818 HANAKPFEVPFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HANAKPFEVPFLK 13 1 A6NFX8;Q9UKK9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 16446800.0 4384200.0 4443600.0 7619000.0 False True 4245025.970789748 6217952.653067877 5623355.334899393 1.0 1.4647619816354347 1.3246927989590649 22.01734194944288 -9.965408276210105 4.817479074603093 0.9999965147431187 1.3947273902366228 0.9137100290235234 0.057183004430196055 7439530.874822894 15389368.22095939 187.7322603837958 0.019575264521549132 1.0829084032146498e-10 9.965408276210105 0.39473087549350416 HANAKPFEVPFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HANAKPFEVPFLK 13 1 A6NFX8;Q9UKK9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 32936700.0 6066600.0 19694000.0 7176100.0 False True 9203475.727868183 16179451.830075698 5757740.689603632 1.0 1.7579719128376918 0.6256050279101794 23.13374737270938 -6.726340212985132 1.7367962591396975 1.4579972584740537 0.626741764466445 0.542137683327502 0.3187348489961082 0.3431324422272335 2.02604545564949 0.14554170532739757 0.36262730017729555 1.8778451941011036e-07 6.726340212985132 -0.8312554940076087 HANAKPFEVPFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HANAKPFEVPFLK 13 1 A6NFX8;Q9UKK9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 13744100.0 3007700.0 4710000.0 6026400.0 False True 4119727.9700363046 4501896.62611284 4603088.437603935 1.0 1.0927655075422777 1.1173282486327296 21.974117647209255 -13.999999986499464 0.1865301161796734 0.5085356754373703 1.1355785172984043 0.9994916837312298 0.0011391081597224748 12.296206618328688 0.13695273637194402 2.1940146271732233 0.01737007563405326 1.000000031086133e-14 13.999999986499464 0.627042841861034 HANAKPFEVPFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HANAKPFEVPFLK 13 1 A6NFX8;Q9UKK9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 12795500.0 4384200.0 4912700.0 3498600.0 False True 3645656.552991514 4886234.3100054 4230141.084301302 1.0 1.3402892562646656 1.1603235309783029 21.797747224877156 -10.150484694674388 4.590027149686662 0.999970217790544 1.250306393621489 0.7206163003490968 0.07347069971119753 2.3733220606382975e-05 4.392486847360834e-06 0.07114666105085728 0.023712566364950043 7.071561217071005e-11 10.150484694674388 0.25033617583094514 HANAKPFEVPFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HANAKPFEVPFLK 13 1 A6NFX8;Q9UKK9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 22104600.0 6066600.0 8764800.0 7273200.0 False True 7853333.290564037 8277031.1751215765 5949552.229334091 1.0 1.0539513438283108 0.7575830553992425 22.90487369480183 -6.859764329410805 1.186954752429288 1.0292531014869366 0.7432981585480306 0.9533483419501392 0.027838682902806697 0.1470472987081612 0.39379931528488116 0.018294762795784077 0.04269334388088266 1.3811335355908822e-07 6.859764329410805 -0.285954942938906 HANAKPFEVPFLK(ub)F ddPTM_RPMI8226_Bortezomib_1h_R1 1 HANAKPFEVPFLKF 14 2 A6NFX8;Q9UKK9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 1 3611500.0 1015300.0 1171300.0 1424900.0 True False 1331068.1321791857 996546.6056916391 1277465.0166059437 1.0 0.748681890580704 0.9597292473034534 20.344152988388668 -10.07416334983246 6.315098384758823 1.000000207487334 0.854205569119214 0.3888644921439053 0.08615972258898427 2.5172854507306147e-07 3.681058925274474e-08 0.08342391201331668 0.02780793089174824 8.430176165317232e-11 10.07416334983246 -0.14579463836812 HAQANGFSVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HAQANGFSVVR 11 0 P53582;H0Y955 P53582 METAP1 Methionine aminopeptidase 1 0 17369800.0 5767200.0 8013500.0 3589100.0 False True 8749264.038796274 6583428.31523873 2879712.81184159 1.0 0.7524550963425353 0.3291377193638542 23.060730236299545 -6.962988046301165 0.3910492103343723 1.025696609566864 0.04066040152340854 0.9998654752940431 0.003212706578508047 0.07865050240651028 0.017309875149916828 0.005462411500422238 0.03559293390113984 1.0889600659029027e-07 6.962988046301165 -0.9850362080434555 down HAQANGFSVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HAQANGFSVVR 11 0 P53582;H0Y955 P53582 METAP1 Methionine aminopeptidase 1 0 12049200.0 5767200.0 3112700.0 3169300.0 False True 7465754.08850773 2939475.5087167905 2592519.9197641383 1.0 0.3937278771667041 0.3472549308521809 22.831856558391994 -13.999999999999998 0.3642718185429472 9.146968518908205 0.3419969915229946 0.9997809336011432 0.00440117563809636 22.165322273002655 0.19540598848679536 140.6557298386004 0.013226005928450541 1.0000000000000041e-14 13.999999999999998 -8.80497152738521 HASAAGFPLSGAASWTLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HASAAGFPLSGAASWTLGR 19 0 K7ES98;K7EM85;Q92619;Q92619-2;K7EQA4 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 0 6853900.0 3484100.0 1244700.0 2125100.0 False True 3373499.152599919 1741715.2010247498 1568472.558366544 1.0 0.5162933566123556 0.4649393663424339 21.685814368765907 -13.999999999999998 0.31680317787746826 5.8665503468801585 0.4543763777445835 0.9996868390760361 0.004265511645373674 17.76872087851999 0.17936086128981063 57.21497470941899 0.01731440921572556 1.0000000000000041e-14 13.999999999999998 -5.412173969135575 HASAAGFPLSGAASWTLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HASAAGFPLSGAASWTLGR 19 0 K7ES98;K7EM85;Q92619;Q92619-2;K7EQA4 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 0 19124300.0 6068300.0 9130700.0 3925300.0 False True 9206054.752154836 7501255.246515287 3149462.7344798897 1.0 0.8148175791328515 0.3421077561745658 23.13415159220613 -6.955013287516679 0.5007929401288159 1.0094021869741123 0.12710728545677685 0.9995382346683149 0.005952410032144225 0.08153295497912492 0.02809826336949581 0.006970275140539359 0.038995360370316944 1.1091408798706055e-07 6.955013287516679 -0.8822949015173355 down HASPEDIK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 HASPEDIKK 9 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 50259600.0 6133700.0 16310000.0 27815900.0 True False 8041340.09883529 13876611.57588204 24937777.496953648 1.0 1.7256590823576696 3.10119671478211 22.939004517598672 -6.961079980536171 0.4199360429219821 0.9391568972858906 3.9395822101460114 0.9998081800373664 0.012068518180101179 0.07931756006770034 0.019722366630661514 0.017793027773204562 0.11450502322820252 1.0937549196403364e-07 6.961079980536171 3.000425312860121 HASPEDIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 HASPEDIKK 9 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 59006800.0 10595100.0 17917600.0 30494100.0 True False 10258764.349964513 25072191.119049653 22506780.406609204 1.0 2.443977682276753 2.193907534944699 23.290353635552833 -10.471404973636048 5.480435036849906 0.9983277731481764 2.3189426086107305 0.9737469786917431 0.10209071014437286 0.002087629248755965 0.0002013540558003937 0.09892977585007742 0.03294963501596816 3.377497423252915e-11 10.471404973636048 1.3206148354625542 HASPEDIK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 HASPEDIKK 9 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 19054300.0 5139200.0 5341700.0 8573400.0 True False 7796542.125846474 4388431.900107409 6878863.732145286 1.0 0.5628690038830457 0.8822967440066829 22.894402979965836 -9.831109912323296 5.623409443255191 1.000000074128585 0.7225828739432457 0.5014160942907883 0.13040582883792445 1.2124031337489952e-07 2.5260981835921964e-08 0.12626493375794517 0.04208830027730712 1.4753331050669576e-10 9.831109912323296 -0.27741720018533933 HASPEDIK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HASPEDIKK 9 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 45271800.0 6133700.0 12965400.0 26172700.0 True False 8401494.6470099 12392545.757155703 19991247.30367655 1.0 1.4750406062052568 2.3794870012553604 23.002214579121564 -6.960996025141449 0.4211611361768826 0.9605180431985331 2.9281926387410717 0.999805375034455 0.007982588620271406 0.07934721993033365 0.019830708510231616 0.011708686947963471 0.07526429184632222 1.0939663786989089e-07 6.960996025141449 1.9676745955425385 HASPEDIK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HASPEDIKK 9 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 12283000.0 5139200.0 4245300.0 2898500.0 True False 6652795.708777033 4009045.323081375 2371002.7411214933 1.0 0.6026106164348685 0.35639193579827344 22.665529302058285 -8.67616605656832 0.1713569214156121 1.3992575225264443 8.96183906746673e-06 0.9998070058409141 0.0036836161461444774 0.24543607065762224 0.047376458216569814 0.19423471440010961 0.14467368200388084 2.1078220503034426e-09 8.67616605656832 -1.3992485606873768 down HASPILPITEFSDIPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HASPILPITEFSDIPR 16 0 G5E972;P42167;H0YJH7 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 0 5261600.0 1384400.0 1948500.0 1928700.0 False True 1814961.8065486713 1657791.3951935114 1729136.6253967877 1.0 0.9134029097537678 0.9527124037309145 20.791507758271045 -10.097917822068425 4.509890639830673 1.000005516239237 0.933057656798527 0.7945238783161115 0.016048033725048184 9.230725779289183e-07 1.8462694356823238e-07 0.015539769545449793 0.0051794806116483155 7.981456994504457e-11 10.097917822068425 -0.06694785944070991 HASPILPITEFSDIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HASPILPITEFSDIPR 16 0 G5E972;P42167;H0YJH7 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 0 5330500.0 1384400.0 2350100.0 1596000.0 False True 1896250.0920032794 2246264.8112585554 1219057.6706517783 1.0 1.1845825720622671 0.6428781075833272 20.854717819793937 -6.81475427291365 1.3944081502286307 1.1000491387382938 0.6323315801267103 0.8718751431821824 0.08048690696879374 0.20039893539302647 0.7670035362818215 0.04537389944611548 0.1047540675095722 1.531954007616764e-07 6.81475427291365 -0.4677175586115835 HAVSDPSILDSLDLNEDER ddPTM_RPMI8226_Bortezomib_2h_R1 1 HAVSDPSILDSLDLNEDER 19 0 P05198;H0YJS4;G3V4T5 P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 0 13579700.0 3069200.0 2606400.0 7904100.0 False True 2971769.925995144 3647149.112196443 5833779.092082729 1.0 1.22726496432093 1.9630655257166976 21.502890996279294 -6.949725507099262 0.5618496200651218 0.9904682556195644 2.235139113996457 0.9991795617523098 0.01177339112291495 0.08359617064618576 0.03642005857867699 0.012592394263705125 0.06118984596612771 1.1227278426635912e-07 6.949725507099262 1.2446708583768924 HAVSDPSILDSLDLNEDER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HAVSDPSILDSLDLNEDER 19 0 P05198;H0YJS4;G3V4T5 P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 0 13122520.0 953720.0 4074900.0 8093900.0 False True 1306336.0573139028 3894857.444107684 6182287.519103026 1.0 2.9815126224995403 4.732539903870593 20.3170946498635 -7.225004355642548 0.2117128064639411 9.434607690516381e-16 7.322017738516659 0.9999825382176682 0.006371603862135411 0.09837196207476738 0.011272989311762485 0.09494713923364892 0.26200406126472375 5.956561695218008e-08 7.225004355642548 7.322017738516658 HAVSEGTK(ub)AVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HAVSEGTKAVTK 12 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 2324780000.0 721500000.0 1055600000.0 547680000.0 True False 945893487.0159388 898108594.6965733 491011327.3175253 1.0 0.9494817408352022 0.5190979048460787 29.817102496146244 -6.928945814901411 0.7554046780050812 1.0068075730788364 0.43307119966809665 0.996326735687643 0.013077878044723193 0.09318931652469516 0.0803918918940424 0.011840617600069693 0.0391706380633352 1.1777529076384865e-07 6.928945814901411 -0.5737363734107397 HAVSEGTK(ub)AVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HAVSEGTKAVTK 12 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 2707125500.0 1110185500.0 1131000000.0 465940000.0 True False 1074943268.9873188 1582614198.0870848 343896336.09962296 1.0 1.4722769505576159 0.3199204516379738 30.001613376396016 -6.79540002883992 1.4743793689155122 1.2621159701089395 0.3057204303490259 0.8184351886208737 0.201543205422165 0.227393601297763 0.9762517454701523 0.10755875322809276 0.25090175781937796 1.6017693205583184e-07 6.79540002883992 -0.9563955397599135 down HAVSEGTK(ub)AVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HAVSEGTKAVTK 12 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 1545670000.0 971300000.0 354000000.0 220370000.0 True False 1473533111.5416164 290825934.1853757 176813772.9083977 1.0 0.19736640589033821 0.11999307753825389 30.45663233339637 -13.999999999999998 0.3308060200518184 9.779752985748685 0.10641928104209877 0.999716512787705 0.00669876531960035 18.891608873962582 0.18396438162714662 115.44781701175816 0.02472015421731184 1.0000000000000041e-14 13.999999999999998 -9.673333704706586 HAVSEGTK(ub)AVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HAVSEGTKAVTK 12 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 2191872190.0 721500000.0 1007412190.0 462960000.0 True False 988258047.8043667 962901388.3791814 353618382.96049285 1.0 0.9743420663443918 0.35781988696791706 29.880312557669136 -6.915649426667227 0.8563735753293523 1.0158505090587022 0.2677109680057375 0.992884511426903 0.025041459865788467 0.10079985020124041 0.11937982057002401 0.021092634178012812 0.06077767945861764 1.2143687236307262e-07 6.915649426667227 -0.7481395410529648 down HAVSEGTK(ub)AVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HAVSEGTKAVTK 12 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 2356984470.0 1110185500.0 1027800000.0 218998970.0 True False 923168432.8067063 1022263037.3976728 264790642.09017 1.0 1.1073418469148575 0.28682809407285276 29.782018651830292 -6.87398773948011 1.1128553658318754 1.062442321441313 0.2350030582981676 0.9685001918639959 0.0646281821681765 0.13308531798431336 0.3056473009884562 0.044954059070634156 0.10722592765169472 1.336633250360515e-07 6.87398773948011 -0.8274392631431454 down HAVSEGTK(ub)AVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HAVSEGTKAVTK 12 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 1438114000.0 971300000.0 436130000.0 30684000.0 True False 1257366997.1853845 411858982.11091787 25099826.844427083 1.0 0.32755669826937084 0.019962212226512253 30.22775865548882 -8.727313070250812 0.4519312264430389 1.092905268050662 4.208490719274892e-21 0.9958221847868949 0.026451399180111766 0.32149034025884526 0.16592830023631608 0.1215441299439454 0.0665260843714516 1.8736433661607533e-09 8.727313070250812 -1.092905268050662 HAVSEGTKAVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HAVSEGTKAVTK 12 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 13064700.0 5068500.0 5594800.0 2401400.0 False True 6644852.583423821 4760077.648359587 2152926.163855365 1.0 0.716355643499756 0.3239990860333052 22.663805762877917 -7.012107359672966 0.3378378523979586 1.0449982865447212 2.2049869665284654e-15 0.9999400919269594 0.0021452439774444702 0.0732536144150617 0.0132708640490752 0.005610029166664904 0.032375383899891884 9.725067857309663e-08 7.012107359672966 -1.044998286544719 down HAVSEGTKAVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HAVSEGTKAVTK 12 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 15166400.0 5750900.0 6990000.0 2425500.0 False True 5568340.8273835005 9781143.452368442 1790188.7865597173 1.0 1.7565633562276914 0.32149411145167034 22.408816087789436 -6.76346811974963 1.5993144782374977 1.4375689017848474 0.3153223664328962 0.704943299535339 0.3183933703463219 0.2771612197632155 1.3979316199652376 0.15701589467764168 0.3760685071640139 1.7239786384635732e-07 6.76346811974963 -1.1222465353519513 HAVSEGTKAVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HAVSEGTKAVTK 12 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 12874920.0 5068500.0 5581320.0 2225100.0 False True 6942461.421062279 5334718.827442917 1699577.2073729772 1.0 0.768418937303456 0.24480902439252183 22.72701582440081 -6.998442345631648 0.4807699869454119 1.0124377173796815 1.9316019159838798e-14 0.9996619167162069 0.005808383408508674 0.07546551373091631 0.024931429382523834 0.007233574177608854 0.04027754540760631 1.0035930713887785e-07 6.998442345631648 -1.0124377173796621 down HAVSEGTKAVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HAVSEGTKAVTK 12 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 17480630.0 5750900.0 10925500.0 804230.0 False True 4782128.158067351 10866642.162958056 972390.7746606165 1.0 2.2723444047868635 0.20333850171292742 22.189221363223712 -6.7403194627897705 1.6854997742568592 1.756757801347987 0.20203456033654055 0.6063867456649452 0.5345811539966 0.3172391533418496 1.7697245422926835 0.2508949640599973 0.6154643216622891 1.8183627965798718e-07 6.7403194627897705 -1.5547232410114464 HAYGDQYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HAYGDQYR 8 0 O75874;C9J4N6 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 2927380.0 1100000.0 758380.0 1069000.0 False True 1065081.1021095577 1061205.0888994555 788996.8306874208 1.0 0.9963608281074322 0.7407856820712438 20.022531860016013 -6.910000931299531 0.8957294473809962 1.0079128703583078 0.7077563349223757 0.9909219011084142 0.011561744055226163 0.10441737097400135 0.13876427537834438 0.009465799872717081 0.02613002874962712 1.230266132631266e-07 6.910000931299531 -0.3001565354359321 HAYGDQYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HAYGDQYR 8 0 O75874;C9J4N6 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 6930930.0 983330.0 2998400.0 2949200.0 False True 1346893.6744940667 2865920.773617143 2252659.700680593 1.0 2.1278003066527638 1.6724851733576958 20.36120453643131 -10.197985123930778 4.9580366366595054 0.9999049631039161 1.9001427400065731 0.8390003879099006 0.18588162479468892 0.0001952922720111127 3.159090983392156e-05 0.17999789522935758 0.05999303643231918 6.338914238312134e-11 10.197985123930778 0.900237776902657 HAYGLGEHYNSVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HAYGLGEHYNSVTR 14 0 A0A087X0W9;Q8N6M0;Q8N6M0-2 A0A087X0W9 OTUD6B OTU domain-containing protein 6B 0 4197600.0 1090700.0 1196600.0 1910300.0 False True 1429918.2623538265 1018071.9443102675 1712640.4808915225 1.0 0.7119791187465444 1.1977191465981414 20.447501250686514 -6.746007199429498 1.664236522981004 0.8298417267709974 1.1984234834903096 0.6318492639471648 0.12101198984024802 0.3070225786938675 1.6717045592158497 0.05746774918371372 0.14012710175940069 1.794703875243097e-07 6.746007199429498 0.36858175671931215 HAYGLGEHYNSVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HAYGLGEHYNSVTR 14 0 A0A087X0W9;Q8N6M0;Q8N6M0-2 A0A087X0W9 OTUD6B OTU domain-containing protein 6B 0 4225390.0 1443100.0 775690.0 2006600.0 False True 1397289.5804130035 1085427.0621699106 1481011.2632903452 1.0 0.7768089574167482 1.0599172025977577 20.41419961149739 -6.696589395529784 1.843799448261119 0.8609408130748977 1.059002396588812 0.4011026067387409 0.09427235742787902 0.402635947370172 2.6588734523762683 0.04083466240849106 0.10543040730110484 2.0109932111145995e-07 6.696589395529784 0.19806158351391434 HAYGLGEHYNSVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HAYGLGEHYNSVTR 14 0 A0A087X0W9;Q8N6M0;Q8N6M0-2 A0A087X0W9 OTUD6B OTU domain-containing protein 6B 0 5413800.0 1090700.0 1818900.0 2504200.0 False True 1493961.265059216 1738534.9837020463 1912759.5356179103 1.0 1.163708206071284 1.280327395598235 20.510711312209406 -6.97478743870876 0.0862878520852478 0.6351176676656304 1.8118534871704237 0.9999998599765375 4.263609870929214e-05 0.07477781600372782 0.0025116912878104095 0.012749253350228544 0.02134070593921485 1.0597722937022428e-07 6.97478743870876 1.1767358195047932 HAYGLGEHYNSVTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HAYGLGEHYNSVTR 14 0 A0A087X0W9;Q8N6M0;Q8N6M0-2 A0A087X0W9 OTUD6B OTU domain-containing protein 6B 0 3924530.0 1443100.0 1779600.0 701830.0 False True 1200001.5901697134 1770012.9415770555 848579.4081047233 1.0 1.4750088300522393 0.7071485696820708 20.194604886931668 -6.739374690083826 1.6889562764257062 1.2828360617747028 0.7067592026876748 0.602114051217663 0.19958209700532148 0.31896470863564585 1.7862907669110086 0.09349171871480928 0.22958054324789168 1.8223228043321076e-07 6.739374690083826 -0.576076859087028 HAYGLGEHYNSVTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HAYGLGEHYNSVTR 14 0 A0A087X0W9;Q8N6M0;Q8N6M0-2 A0A087X0W9 OTUD6B OTU domain-containing protein 6B 0 8558300.0 2485200.0 2304500.0 3768600.0 False True 3217140.39061579 2176252.549181691 3082753.4691014183 1.0 0.6764555738784953 0.9582278342883728 21.617347463482638 -10.182186869073076 7.281725770627958 1.0000002025575865 0.8173417048643175 0.3590978449488311 0.11503304361247091 3.7824206875836465e-07 4.262227303827076e-08 0.1113803883599311 0.037126755181220945 6.573749199354804e-11 10.182186869073076 -0.18265849769326903 HAYVSFKPCMTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HAYVSFKPCMTR 12 1 O43164-2;O43164 O43164-2 PJA2 E3 ubiquitin-protein ligase Praja-2 0 10054800.0 2691800.0 3160500.0 4202500.0 False True 3528975.8674282813 2688965.719532511 3767665.613226527 1.0 0.7619677267705652 1.067637114779192 21.750818133740314 -6.698962128640382 1.8353804111106065 0.8520344830242612 1.066686200826237 0.4123186149389533 0.10049624407431418 0.3976663858466618 2.6038155271921193 0.043702540274260966 0.11250183247465947 2.0000362692476023e-07 6.698962128640382 0.21465171780197578 HAYVSFKPCMTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HAYVSFKPCMTR 12 1 O43164-2;O43164 O43164-2 PJA2 E3 ubiquitin-protein ligase Praja-2 0 12934800.0 2981800.0 5012500.0 4940500.0 False True 4523608.598779778 4117980.2121587517 3964008.0095019285 1.0 0.9103307950359714 0.8762933226741149 22.109042676143595 -13.9999999944456 0.13430181682332762 1.426681264428422 0.8311315801518299 0.9996265835680638 0.0010082614574536254 11.932407344680689 0.11436726575139525 1.3392387899545437 0.040239134210390014 1.0000000127894778e-14 13.9999999944456 -0.595549684276592 HAYVSFKPCMTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HAYVSFKPCMTR 12 1 O43164-2;O43164 O43164-2 PJA2 E3 ubiquitin-protein ligase Praja-2 0 8371200.0 2691800.0 2119500.0 3559900.0 False True 3687031.2031598 2025853.4817507789 2719124.938441891 1.0 0.5494538478585738 0.7374835710941613 21.814028195263205 -10.204870853081971 5.441013225796449 1.0000168185846952 0.6434687094763258 0.8274020708708278 0.07676281306746859 1.5661788278903504e-05 2.288758696711114e-06 0.0743287762410967 0.02477509138484033 6.239203441945317e-11 10.204870853081971 -0.3565481091083693 HAYVSFKPCMTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HAYVSFKPCMTR 12 1 O43164-2;O43164 O43164-2 PJA2 E3 ubiquitin-protein ligase Praja-2 0 17330300.0 2981800.0 8746600.0 5601900.0 False True 3859998.880065257 8259844.021120676 4582411.680347939 1.0 2.139856584875754 1.187153629503247 21.880168998236044 -6.602112903303913 2.1827134783428055 1.7655346287593927 1.1903122001112838 0.02660885141008862 0.49241885097174476 0.6347943781995772 5.71873641940773 0.18705050326608116 0.5475394614819684 2.4996954327360863e-07 6.602112903303913 -0.5752224286481089 HCGNIPVFVINYPLTLKPFYMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HCGNIPVFVINYPLTLKPFYMR 22 1 Q96I59-2;Q96I59;E9PRK2 Q96I59-2 NARS2 Probable asparagine--tRNA ligase, mitochondrial 0 74581000.0 17011000.0 20777000.0 36793000.0 False True 25806930.670683086 17069182.018558048 29520847.423055213 1.0 0.6614185249836315 1.1439116026529714 24.621255229916926 -6.718081019701008 1.7660906835802357 0.7935920770070652 1.143086271101381 0.5035034416496276 0.14251081196551696 0.35906015952162673 2.1876409847877385 0.06409556520986277 0.16127603387452566 1.9138988447830386e-07 6.718081019701008 0.3494941940943157 HCGNIPVFVINYPLTLKPFYMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HCGNIPVFVINYPLTLKPFYMR 22 1 Q96I59-2;Q96I59;E9PRK2 Q96I59-2 NARS2 Probable asparagine--tRNA ligase, mitochondrial 0 49222000.0 17011000.0 16179000.0 16032000.0 False True 22021074.836940814 15278624.427515987 13114340.502211438 1.0 0.6938182872838602 0.595535894560962 24.392381552009375 -13.999999997136236 0.15896997579043623 2.5046657727849206 0.4978129415333834 0.9995391143304404 0.0036976749149484666 12.002984659180967 0.12596288535263134 5.569221437090976 0.08895206175767452 1.0000000065940612e-14 13.999999997136236 -2.0068528312515372 HCIMQANAEYHQSILAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HCIMQANAEYHQSILAK 17 0 Q8WUM4;Q8WUM4-2;F8WDK9 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 13337800.0 2744800.0 4949900.0 5643100.0 False True 3598459.380681009 4211394.2145590745 5059206.144437498 1.0 1.1703325698682938 1.4059367104708134 21.77894794266325 -6.966569361078143 0.33001043366864535 0.9712994052568772 1.6126828193633977 0.999941934621526 0.0012682363790857908 0.07743237156386427 0.013003630322835875 0.0034377086281159983 0.02054974262680187 1.0800171178058299e-07 6.966569361078143 0.6413834141065206 HCIMQANAEYHQSILAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HCIMQANAEYHQSILAK 17 0 Q8WUM4;Q8WUM4-2;F8WDK9 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 24653500.0 5014700.0 12684000.0 6954800.0 False True 7607666.523677293 10420441.099455664 5580180.731602871 1.0 1.369728952632741 0.7334943920367315 22.859022577459914 -6.749184461440431 1.6530933185646777 1.217619387959576 0.7323254296591553 0.6453679198955291 0.15535584291375154 0.3014656605893175 1.620655038218592 0.07425099605494784 0.18039969197428649 1.7816218839147277e-07 6.749184461440431 -0.48529395830042077 HCIMQANAEYHQSILAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HCIMQANAEYHQSILAK 17 0 Q8WUM4;Q8WUM4-2;F8WDK9 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 11228100.0 2744800.0 4356200.0 4127100.0 False True 3759626.735430943 4163728.679972983 3152363.980292575 1.0 1.1074845916839988 0.8384779134014853 21.842158004186143 -6.79827592179527 1.4629284181206894 1.0594352946817793 0.8349204483598773 0.8270646426483703 0.04597594163851958 0.22323642054909182 0.9433864481705568 0.024725716003320006 0.05756468844292705 1.591197464925334e-07 6.79827592179527 -0.224514846321902 HCIMQANAEYHQSILAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HCIMQANAEYHQSILAK 17 0 Q8WUM4;Q8WUM4-2;F8WDK9 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 3730400.0 1980100.0 0.0 1750300.0 False True 1646540.8833033387 0.0 2116279.6375271725 1.0 0.0 1.2852882421488558 20.65100690355122 -6.6990932970682495 1.834348771934512 0.3784683941333304 1.2813652253808285 0.4131139751400297 0.42218584573267065 0.3974381657259482 2.599354598062006 0.18366751647131171 0.47283066262494733 1.9994322965724276e-07 6.6990932970682495 0.9028968312474981 HCIMQANAEYHQSILAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HCIMQANAEYHQSILAK 17 0 Q8WUM4;Q8WUM4-2;F8WDK9 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 20855800.0 5014700.0 8349300.0 7491800.0 False True 6491628.00451514 7884654.115375448 6128369.272359501 1.0 1.21458809868517 0.944041967299577 22.630148899552363 -6.695309071586088 1.8473055515264079 1.133854220817085 0.944905394288124 0.3955226119317281 0.09065971537421426 0.4053399646752304 2.6857233111991485 0.03919974727280308 0.10141025524599193 2.0169304767498363e-07 6.695309071586088 -0.18894882652896094 HCLGVFFPVFAYASR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HCLGVFFPVFAYASR 15 0 Q9BPX3 Q9BPX3 NCAPG Condensin complex subunit 3 0 117509000.0 34796000.0 35003000.0 47710000.0 False True 52788075.92834567 28756441.170312766 38280097.58796415 1.0 0.5447525916524528 0.7251656158092483 25.653708746412125 -10.13685784953005 5.247818919748869 1.0000107827072526 0.6349591037305901 0.8451691099410525 0.07365330869033823 9.29214011541209e-06 1.5283371311955293e-06 0.07131661449672978 0.023771503162431575 7.296963106632349e-11 10.13685784953005 -0.3650516789766626 HCLGVFFPVFAYASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HCLGVFFPVFAYASR 15 0 Q9BPX3 Q9BPX3 NCAPG Condensin complex subunit 3 0 14580180.0 714480.0 4727500.0 9138200.0 False True 978642.564096001 4518623.4182480825 6979945.367136636 1.0 4.617235734501349 7.1322724181572905 19.90042250570032 -8.120174040755577 0.299469909474096 4.036572775369834e-23 8.679788036175436 0.9989922960873165 0.07989841039323646 0.09482090678804364 0.06666895660799754 0.5648198898654248 0.7441261995039588 7.58273640787366e-09 8.120174040755577 8.679788036175436 HCLGVFFPVFAYASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HCLGVFFPVFAYASR 15 0 Q9BPX3 Q9BPX3 NCAPG Condensin complex subunit 3 0 100775400.0 34796000.0 36233000.0 29746400.0 False True 45044107.931702554 34216601.69863319 24332860.423838697 1.0 0.7596243608712063 0.5402007397001407 25.424835068504574 -6.972214218479189 0.1983010478209023 1.1335039468820447 0.16027404639959614 0.9999948917271806 0.00042436517794186297 0.07559063268591322 0.006389533545078434 0.007224582241449523 0.023395601753332235 1.066070145729648e-07 6.972214218479189 -0.9732299004824485 HCLQTVWNKPTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HCLQTVWNKPTVK 13 1 C9JIZ6;P07602;P07602-2;P07602-3;Q5BJH1 C9JIZ6 PSAP Prosaposin;Saposin-A;Saposin-B-Val;Saposin-B;Saposin-C;Saposin-D 0 10010500.0 3817900.0 3470500.0 2722100.0 False True 5229480.804868042 3317161.8345912118 2079196.043409278 1.0 0.6343195354122569 0.3975912946221711 22.318236288755447 -8.460590171126743 0.15973345942207193 1.3925843273876368 5.493355016491312e-08 0.9998794940061272 0.002720261164248002 0.1374447957962878 0.03865535715003332 0.15799809135632248 0.13991332350019978 3.4626598308349127e-09 8.460590171126743 -1.3925842724540867 down HCLVTYRPDK(ub)NHTTIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HCLVTYRPDKNHTTIR 16 2 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 6294100.0 1919800.0 2554000.0 1820300.0 True False 2516876.3913696446 2172953.155414028 1631952.8175505619 1.0 0.8633531479198076 0.6484040388898394 21.263202934040386 -6.964455170535785 0.3672829375345457 1.0170473861002753 0.4872595705872618 0.9999014686186675 0.0014365232956453657 0.0781463348814351 0.01551481070697261 0.0028454423510449675 0.01828255245044515 1.0852875712019855e-07 6.964455170535785 -0.5297878155130136 HCNGVDWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HCNGVDWR 8 0 O15371-2;O15371-3;O15371 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 0 7799400.0 2170500.0 2716900.0 2912000.0 False True 2845546.5191518962 2311549.110393251 2610694.1738764127 1.0 0.8123392447937202 0.9174666997377079 21.44027433424584 -10.208762528778564 4.639354096432151 1.0000202296959906 0.8649029722834969 0.6876856425011102 0.042918104051801576 1.2799096502145129e-05 2.1828575112161357e-06 0.0415641389003655 0.01385175847662062 6.183544224876691e-11 10.208762528778564 -0.1351172574124937 HCNGVDWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HCNGVDWR 8 0 O15371-2;O15371-3;O15371 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 0 1865380.0 833650.0 475530.0 556200.0 False True 807186.2370669391 665411.6088561898 410514.53435766394 1.0 0.8243594579537012 0.5085747445959246 19.62254205041162 -6.962073401452917 0.4051546389161966 1.0164023129644524 0.304904738781705 0.999839535436627 0.0025756010750378 0.07896860476518303 0.01845458005204157 0.004062767491628744 0.026408534548718728 1.0912558843313834e-07 6.962073401452917 -0.7114975741827474 HCNGVDWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HCNGVDWR 8 0 O15371-2;O15371-3;O15371 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 0 17868800.0 5727000.0 8754800.0 3387000.0 False True 8688277.699782614 7192437.538435394 2717557.9654251602 1.0 0.8278323721875687 0.31278442740074425 23.05063878546098 -6.951514006660134 0.5419669462652429 1.0074862702678422 0.1092652688251046 0.9993148066641252 0.0076424779908789145 0.08288342011119354 0.03348988254117034 0.008383334773276064 0.0426668834318389 1.118113763126676e-07 6.951514006660134 -0.8982210014427376 down HCNGVDWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HCNGVDWR 8 0 O15371-2;O15371-3;O15371 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 0 9912600.0 2170500.0 2814600.0 4927500.0 False True 2972992.5055570006 2690241.6653624605 3763725.9850480193 1.0 0.9048935240616875 1.2659722411048837 21.50348439576873 -6.836695774663544 1.297701560251715 0.9493649522082852 1.2770887562249205 0.9186135524677268 0.0435947584723166 0.17269429862779034 0.5663549280741945 0.026355805980516372 0.06067385972847423 1.4564789937297099e-07 6.836695774663544 0.32772380401663526 HCNGVDWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HCNGVDWR 8 0 O15371-2;O15371-3;O15371 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 0 2601200.0 833650.0 621750.0 1145800.0 False True 693216.9119568854 618400.5093422884 1385381.4824193767 1.0 0.8920736044892537 1.9984819448627944 19.402947325845897 -6.882937864774944 1.0632372944040045 0.9301036253159309 2.081460843066884 0.9759806522704407 0.07719332701687126 0.12506136474485724 0.25680827814826546 0.05576928150605926 0.1359345132055587 1.309369243207854e-07 6.882937864774944 1.1513572177509532 HCNGVDWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HCNGVDWR 8 0 O15371-2;O15371-3;O15371 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 0 12777900.0 5727000.0 2851800.0 4199100.0 False True 7413714.396047265 2693094.823066324 3434906.8864044417 1.0 0.3632585070315345 0.4633179406311922 22.82176510755343 -10.46183966696553 6.599205842679173 1.0001648139587984 0.4132882238313633 0.9786520560059133 0.04084909271184269 9.908066870041078e-05 8.080008455706008e-06 0.039562824660107854 0.013183987981720787 3.4527118318205563e-11 10.46183966696553 -0.5868765901274351 HCNMVLENVK ddPTM_RPMI8226_Bortezomib_1h_R1 2 HCNMVLENVK 10 0 P62316;P62316-2 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 47841800.0 9954100.0 21402100.0 16485600.0 False True 13049921.49564153 18208990.104732387 14779828.253041577 1.0 1.3953333060903015 1.1325607022216808 23.637537792218243 -10.31720693216761 4.965463733619869 0.9998925682819211 1.2639470041560883 0.5736113161416323 0.1072764663104385 0.0001276363754723477 1.755104280130139e-05 0.10391211096064451 0.034623330621644376 4.817182143570366e-11 10.31720693216761 0.2640544358741672 HCNMVLENVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HCNMVLENVK 10 0 P62316;P62316-2 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 11112600.0 5070600.0 3220000.0 2822000.0 False True 4909636.578506119 4505762.792078164 2082833.5418146872 1.0 0.9177385576366137 0.42423375101389726 22.227184806533874 -6.935837436780492 0.6972109110303618 1.00613428725544 0.3060073351042073 0.9975662941258648 0.012543170724918949 0.08971793510469217 0.06364778035447947 0.01185435046570572 0.04331070889144076 1.1592111858392129e-07 6.935837436780492 -0.7001269521512327 down HCNMVLENVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HCNMVLENVK 10 0 P62316;P62316-2 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 16558400.0 5787000.0 7292700.0 3478700.0 False True 8779302.08637016 5991260.706874824 2791133.420231623 1.0 0.6824301804327063 0.3179220162118409 23.065674826106143 -7.18652794824599 0.30676793622890697 1.067280508072212 1.2262763477270848e-16 0.999918443654503 0.0025166838133250115 0.08765496893916254 0.016116943928497034 0.009202078953538506 0.03929078719242126 6.508367260572173e-08 7.18652794824599 -1.0672805080722119 down HCNMVLENVK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 HCNMVLENVK 10 0 P62316;P62316-2 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 50382700.0 9954100.0 15807300.0 24621300.0 False True 13634399.769437915 15108881.21824914 18806256.031590626 1.0 1.1081442141748212 1.379324088306817 23.700747853741134 -6.955396901434077 0.496073148150198 0.9943792904826998 1.5047073736832206 0.9995595557888113 0.0033485399809405616 0.08138832467250835 0.02753370669985247 0.003956592701664037 0.02236748995403385 1.10816160420385e-07 6.955396901434077 0.5103280832005208 HCNMVLENVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HCNMVLENVK 10 0 P62316;P62316-2 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 12474900.0 5070600.0 2944000.0 4460300.0 False True 4216428.565667351 2928140.0876617553 5392928.107902907 1.0 0.694459787959981 1.279027504892484 22.00759008196815 -6.764670408327994 1.5946631084313698 0.8235534295378686 1.2816849827520809 0.709759015881521 0.12861375322194737 0.27517547529763 1.3800685832255422 0.0636020121014361 0.15216315820750284 1.7192126247821084e-07 6.764670408327994 0.4581315532142123 HCNMVLENVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HCNMVLENVK 10 0 P62316;P62316-2 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 13240300.0 5787000.0 3420100.0 4033200.0 False True 7491385.578824073 3229768.4284904776 3299198.9841266936 1.0 0.431130982981316 0.44039903558729526 22.836801148198592 -10.328906181456954 5.755097331019703 1.0000774907333987 0.43576500928430334 0.9997976834778584 0.0037836666323292846 3.7624991078482936e-06 4.387353079258445e-07 0.0036640186892716465 0.0012211731545496774 4.689146685797192e-11 10.328906181456954 -0.5643124814490954 HCPTVQHVLVAHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HCPTVQHVLVAHR 13 0 Q9NUB1-3;Q9NUB1-4;Q9NUB1-2;Q9NUB1 Q9NUB1-3 ACSS1 Acetyl-coenzyme A synthetase 2-like, mitochondrial 0 4141700.0 1114900.0 1372800.0 1654000.0 False True 1461644.696706958 1167983.591132487 1482859.9462883202 1.0 0.7990885840888139 1.0145146420529965 20.479161226308285 -11.123077833271527 11.4333526585754 3.380129943641611 0.9068016130707914 0.19971244204430905 0.0879473198852466 0.03786158269689528 0.00040757344917633235 0.0006042402478671282 0.02838487543826137 7.532205611569214e-12 11.123077833271527 -2.473328330570819 HCPTVQHVLVAHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HCPTVQHVLVAHR 13 0 Q9NUB1-3;Q9NUB1-4;Q9NUB1-2;Q9NUB1 Q9NUB1-3 ACSS1 Acetyl-coenzyme A synthetase 2-like, mitochondrial 0 3929700.0 1114900.0 1281500.0 1533300.0 False True 1527108.6590396238 1224879.092646201 1171166.119304743 1.0 0.8020903328624365 0.766917345646689 20.542371287831177 -13.999999999999998 0.2429931974187108 2.3292306935112936 0.7518013269301548 0.999530026914845 0.0022241505997639033 13.730999915583315 0.15600397315558925 8.871982120023542 0.016889702021588435 1.0000000000000041e-14 13.999999999999998 -1.5774293665811387 HCQDEHDNEIK(ub)IK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HCQDEHDNEIKIK 13 1 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 6577290.0 774490.0 1890100.0 3912700.0 True False 1174957.952803323 1552796.8875812958 3139353.1300026663 1.0 1.3215765584432104 2.6718855108921202 20.164177698567613 -6.943760244692225 0.6235993730768475 0.9852510832283183 3.080191144434967 0.9986161120007376 0.026945717788922605 0.08609226928833248 0.047106646150484974 0.02704796634523546 0.11443415594668747 1.1382554943147785e-07 6.943760244692225 2.094940061206649 up HCQDEHDNEIK(ub)IK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HCQDEHDNEIKIK 13 1 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 10033690.0 774490.0 1673500.0 7585700.0 True False 1002592.5724802938 1580368.2538752717 6205180.435854863 1.0 1.5762816295014335 6.189134655669742 19.935304020660062 -6.93008524264832 0.7460915342627594 0.9300728936896794 7.138189773662353 0.9965549533534146 0.13630619378067374 0.09259373317391208 0.07746347613499564 0.12424418965517528 0.4171887558658927 1.1746669704971178e-07 6.93008524264832 6.208116879972674 up HDADGQATLLNLLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HDADGQATLLNLLLR 15 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 22822200.0 4947200.0 8756500.0 9118500.0 False True 6485827.108752956 7450064.332569669 8175005.090828334 1.0 1.1486683514143363 1.2604414138322846 22.628859136030446 -6.974273014961646 0.11757404538212306 0.7912791643052405 1.6206976853960553 0.9999994909892027 7.58914035657211e-05 0.07493885054365575 0.0034946738130102366 0.008100306097424924 0.016337355807661956 1.0610283424526106e-07 6.974273014961646 0.8294185210908148 HDADGQATLLNLLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HDADGQATLLNLLLR 15 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 37955600.0 12911700.0 12745300.0 12298600.0 False True 12501825.151007267 17834564.75586148 9077227.709908608 1.0 1.426556885929936 0.7260722014798984 23.575635394626172 -6.74190692174815 1.6799719381253606 1.253239060906153 0.7255086813526912 0.613383568887476 0.1792143235332725 0.31436707910755024 1.7428607863219021 0.0843721518352309 0.20658927902278262 1.8117283417097493e-07 6.74190692174815 -0.5277303795534618 HDADGQATLLNLLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HDADGQATLLNLLLR 15 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 35600700.0 9506900.0 21174000.0 4919800.0 False True 14422662.347487891 17395334.266782913 3947399.373575059 1.0 1.206111177511744 0.27369422360931916 23.781834167277513 -6.848727045531012 1.241121736269656 1.1098874103539493 0.23730674810361913 0.9384401819844859 0.09922443881956616 0.15886838814129786 0.4715466711792793 0.06257633539183262 0.14470094351698995 1.4166838872970912e-07 6.848727045531012 -0.8725806622503303 down HDADGQATLLNLLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HDADGQATLLNLLLR 15 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 66943200.0 4947200.0 32260000.0 29736000.0 False True 6776313.5330530405 30834646.53044593 22712969.232143655 1.0 4.550357119699789 3.351817934833724 22.692069197553337 -9.616935423702463 8.472075939596298 1.0000048426432195 3.951087527266763 0.8899100513589766 0.48930157328353496 0.0 0.0 0.4737642182060375 0.1579214037154782 2.4158200218655576e-10 9.616935423702463 2.951082684623543 HDADGQATLLNLLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HDADGQATLLNLLLR 15 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 24290600.0 12911700.0 2095800.0 9283100.0 False True 10736650.635295058 2084509.5094162733 11224153.289795171 1.0 0.19414895577991284 1.045405468712703 23.356040670060448 -11.919513284371156 17.95800725469156 0.9403626174298594 0.6577994918380894 0.0 0.4009619269881817 0.0 0.0 0.0 0.11615078053470755 1.203612572651336e-12 11.919513284371156 -0.28256312559177 HDADGQATLLNLLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HDADGQATLLNLLLR 15 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 27269500.0 9506900.0 11420900.0 6341700.0 False True 12306869.45901547 10785316.875222033 5187575.671336958 1.0 0.8763655868082021 0.42151870454242685 23.552960489369962 -6.946799208968085 0.592950593315801 1.0052131870400716 0.2696678208995544 0.9989255000847119 0.008153348958627606 0.08479721199075933 0.04148310604299899 0.008427380689365946 0.038138906850178116 1.1303183835194055e-07 6.946799208968085 -0.7355453661405171 down HDCVGYVMK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HDCVGYVMKK 10 1 P51784;G5E9A6 P51784 USP11 Ubiquitin carboxyl-terminal hydrolase 11;Ubiquitin carboxyl-terminal hydrolase 1 5766830.0 885190.0 999040.0 3882600.0 True False 1145895.9047035212 943442.5457732592 3176006.6388402027 1.0 0.8233230801338426 2.771636259283023 20.128044562294196 -6.884747206440923 1.0529199920966688 0.881757768062132 2.9229521848517797 0.9773191502756879 0.13249362004186996 0.12351020116919073 0.2475541964974551 0.09647740319653948 0.23640155264069593 1.3039255448609312e-07 6.884747206440923 2.0411944167896476 up HDDPALTLVAGLTSNKPTDK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HDDPALTLVAGLTSNKPTDKLR 22 2 Q6P996;Q6P996-5;Q6P996-4;Q6P996-3;H3BND4;Q86XE2;J3KNK7;Q6P996-2;Q6XYB5 Q6P996 PDXDC1 Pyridoxal-dependent decarboxylase domain-containing protein 1 1 33751500.0 2367000.0 8337500.0 23047000.0 True False 3064128.160545464 7873510.795748475 18852682.4821898 1.0 2.5695762002157454 6.152706902061733 21.54704521016295 -6.957377880514804 0.4709349383960531 0.9062144128752802 7.963191168392253 0.999660248775863 0.0397485626931055 0.08065142767064376 0.024695563931207424 0.0496300580131619 0.29571616421982205 1.1031183766576058e-07 6.957377880514804 7.056976755516973 HDDYLVMLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HDDYLVMLK 9 0 Q9Y224;G3V4C6;H0YJB9 Q9Y224 C14orf166 UPF0568 protein C14orf166 0 8660000.0 1729300.0 2504600.0 4426100.0 False True 2267129.046565023 2130923.442854332 3968129.6301491805 1.0 0.9399215479519972 1.7502883817581454 21.112435081947073 -6.88905015976867 1.0280150731108904 0.9554611777763982 1.8186964253974127 0.9802822575921478 0.051768138584681135 0.11991598274453381 0.22639120636491433 0.03841756929704453 0.09545125777965334 1.2910701500978246e-07 6.88905015976867 0.8632352476210146 HDDYLVMLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HDDYLVMLK 9 0 Q9Y224;G3V4C6;H0YJB9 Q9Y224 C14orf166 UPF0568 protein C14orf166 0 9752100.0 1729300.0 3844000.0 4178800.0 False True 2368668.9425753187 3674159.3695918834 3191853.5050874962 1.0 1.551149383331374 1.347530441133397 21.175645143469964 -10.05173167929391 4.385491170998898 0.9999698372717111 1.4493399122862431 0.8665439613797045 0.08312708524484579 19195700.817936596 0.14060438210290702 6044.88858283157 0.02845661230250709 8.877042941083664e-11 10.05173167929391 0.4493700750145321 HDDYLVMLK(ub)AIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HDDYLVMLKAIR 12 1 Q9Y224;G3V4C6;H0YJB9 Q9Y224 C14orf166 UPF0568 protein C14orf166 1 28092200.0 8775200.0 0.0 19317000.0 True False 13312619.953052627 0.0 15498986.483058136 1.0 0.0 1.1642326257127298 23.666291188978708 -10.673690892102309 4.565189115988097 1.0135329534957942 0.5821163128575274 0.1465967476082315 0.47529597914958605 0.06624263096282296 0.0047348654346816895 0.4656612936258941 0.1534011176471257 2.1198694096256126e-11 10.673690892102309 -0.4314166406382668 HDDYLVMLK(ub)AIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HDDYLVMLKAIR 12 1 Q9Y224;G3V4C6;H0YJB9 Q9Y224 C14orf166 UPF0568 protein C14orf166 1 20486200.0 8775200.0 0.0 11711000.0 True False 11359669.385052204 0.0 9579718.165007362 1.0 0.0 0.8433095929370077 23.437417511071157 -9.734788891736777 11.077118093261463 1.0000030727775717 0.42165479647174287 0.3854107866215215 0.34427969965288047 0.0 0.0 0.333347385796159 0.11111579526538633 1.8416670085677334e-10 9.734788891736777 -0.5783482763058289 HDIAFVEFENDGQAGAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HDIAFVEFENDGQAGAAR 18 0 P08579 P08579 SNRPB2 U2 small nuclear ribonucleoprotein B 0 6336700.0 1498300.0 2572600.0 2265800.0 False True 1964285.8095578419 2188778.1079162583 2031356.7510883203 1.0 1.1142869827120268 1.0341452049412179 20.905573430765074 -10.092747772880584 4.677133788644491 0.9999963680233958 1.0742160938192604 0.5334622855463373 0.032717743776474066 1.445913556648368e-06 2.80408480108824e-07 0.031680628130728854 0.010559606412942603 8.077039878595084e-11 10.092747772880584 0.07421972579586467 HDIAFVEFENDGQAGAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HDIAFVEFENDGQAGAAR 18 0 P08579 P08579 SNRPB2 U2 small nuclear ribonucleoprotein B 0 6792400.0 1498300.0 2875700.0 2418400.0 False True 2052262.0000350445 2748642.0653317794 1847223.7285114415 1.0 1.3393231786608355 0.9000915713880091 20.968783492287965 -6.700417330318917 1.82938367345268 1.2106208701509689 0.9013884053056379 0.41954275559591825 0.14322177422534077 0.3946630475190008 2.5681108754150985 0.0624510184983469 0.16052469962784105 1.993345911371314e-07 6.700417330318917 -0.30923246484533096 HDLDLICR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HDLDLICR 8 0 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;P62140;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 0 10102700.0 2756800.0 0.0 7345900.0 False True 3614191.4968891726 0.0 6585816.734848468 1.0 0.0 1.8222102344375082 21.785241518330544 -6.757701256908924 1.6211091148325283 0.41749331707562515 1.828126955964629 0.6815370708216278 0.420475074576957 0.28678720782785566 1.4848782334977426 0.2047016272104114 0.49305611790227455 1.7470234846260005e-07 6.757701256908924 1.4106336388890037 HDLGHFMLR ddPTM_RPMI8226_Bortezomib_1h_R1 2 HDLGHFMLR 9 0 P30043;M0R192;A0A2R8YEP4 P30043 BLVRB Flavin reductase (NADPH) 0 37864800.0 9727800.0 13029300.0 15107700.0 False True 12753240.004149212 11085379.22781361 13544500.127291448 1.0 0.8692206234813294 1.0620438510437193 23.60436047946057 -6.724079821689078 1.744878731839196 0.9207820470159245 1.0618091535916998 0.53156491758454 0.055006830088938245 0.3474617929644172 2.0695936369611903 0.025011609769180557 0.06248344017081034 1.8876443752886877e-07 6.724079821689078 0.14102710657577533 HDLGHFMLR ddPTM_RPMI8226_Bortezomib_2h_R1 2 HDLGHFMLR 9 0 P30043;M0R192;A0A2R8YEP4 P30043 BLVRB Flavin reductase (NADPH) 0 16880900.0 3967780.0 3310020.0 9603100.0 False True 3841824.9957529614 4631728.247526266 7087760.023175267 1.0 1.2056062555286933 1.844894036300613 21.873360371641063 -6.950643664927963 0.5517329450157942 0.9912483058154367 2.0893741451965346 0.9992508255800566 0.009846852887068614 0.08322832394257872 0.03490077634132556 0.01066389995622359 0.053051894531317235 1.1203567500088074e-07 6.950643664927963 1.098125839381098 HDLGHFMLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HDLGHFMLR 9 0 P30043;M0R192;A0A2R8YEP4 P30043 BLVRB Flavin reductase (NADPH) 0 26589500.0 6021900.0 15473000.0 5094600.0 False True 9135662.559860464 12711722.2588992 4087650.076957499 1.0 1.3914395563109936 0.44743882013741243 23.123077932786906 -6.794085763588114 1.4797707700961764 1.2176300908912725 0.43621380018553096 0.8143024547638547 0.16687766944628155 0.22934196802434706 0.9919249119758907 0.088740755444786 0.20718077134222215 1.6066239488644959e-07 6.794085763588114 -0.7814162907057416 down HDLGHFMLR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 HDLGHFMLR 9 0 P30043;M0R192;A0A2R8YEP4 P30043 BLVRB Flavin reductase (NADPH) 0 36937500.0 9727800.0 12767900.0 14441800.0 False True 13324430.543910362 12203771.960200865 11030944.278207293 1.0 0.9158944481704947 0.8278735996900628 23.667570540983462 -6.97055162303099 0.24465288432383822 1.0298370328782511 0.7113703517835644 0.999986364252153 0.00025944259708487116 0.07612412410167052 0.008387196236549375 0.0020365205564941767 0.008511722145266045 1.0701591693598073e-07 6.97055162303099 -0.3184666810946867 HDLGHFMLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HDLGHFMLR 9 0 P30043;M0R192;A0A2R8YEP4 P30043 BLVRB Flavin reductase (NADPH) 0 11678900.0 3188100.0 5967500.0 2523300.0 False True 2651046.4067771225 5935351.89304399 3050910.363578997 1.0 2.2388713671216336 1.1508324998686044 21.338130494241238 -6.614863714763082 2.135909817805521 1.8249812735206359 1.1548806315291074 0.06571697035526736 0.5334610275627312 0.5993479872521182 5.18842542503927 0.20575219522549562 0.5917722374936445 2.4273717050979336e-07 6.614863714763082 -0.6701006419915285 HDLGHFMLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HDLGHFMLR 9 0 P30043;M0R192;A0A2R8YEP4 P30043 BLVRB Flavin reductase (NADPH) 0 18345000.0 6021900.0 6300500.0 6022600.0 False True 7795468.259395319 5949871.636415383 4926548.5970944725 1.0 0.7632474969344438 0.6319759677241783 22.894204254879355 -13.999999999996673 0.07026887858796375 2.367251751611016 0.1581913324645758 0.9999234994453714 0.001331971306223367 12.357587240060866 0.07163358704629105 2.7652045694115555 0.43621583286468685 1.000000000007661e-14 13.999999999996673 -2.2090604191464402 HDSPEDVK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 HDSPEDVKR 9 1 P31948;P31948-2;P31948-3;H0YGI8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 4746650.0 1863700.0 1990600.0 892350.0 True False 2443328.748096471 1693610.239298028 800018.1820256254 1.0 0.6931569239781884 0.3274296112010703 21.220416559552273 -7.119166622182077 0.3082713963298653 1.063410951390681 4.343203589740307e-13 0.9999440519940731 0.0020563963723308565 0.07845373213078488 0.013621950921284825 0.00739263033245357 0.03440202100197675 7.6003462477968e-08 7.119166622182077 -1.0634109513902468 down HDSPEDVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 HDSPEDVKR 9 1 P31948;P31948-2;P31948-3;H0YGI8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 6230500.0 2362900.0 2843500.0 1024100.0 True False 2287891.0328860683 3978924.3786566034 755857.4876585476 1.0 1.7391232018761729 0.33037302773334815 21.125586910750563 -6.764110908013739 1.5966805532801962 1.4271158434033082 0.32409555194499273 0.7076463618801087 0.3110918899950867 0.2760621452911708 1.3878972304211963 0.15365344539684705 0.36781707604922914 1.7214289087014155e-07 6.764110908013739 -1.1030202914583156 HDSPEDVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HDSPEDVKR 9 1 P31948;P31948-2;P31948-3;H0YGI8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 4803970.0 2362900.0 1447200.0 993870.0 True False 1964856.0442187067 1439403.6463532927 1201683.6218643275 1.0 0.7325746079915225 0.6115886328670748 20.90599218618484 -13.999999999984501 0.10696305439675233 2.297883440107074 0.37961603559825896 0.999758500951042 0.0025218855697997046 12.03140262089571 0.09873398958681917 3.3923683151698287 0.20622737690637286 1.0000000000356871e-14 13.999999999984501 -1.918267404508815 HDVGAYMLMYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HDVGAYMLMYK 11 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 9881300.0 1908000.0 3943700.0 4029600.0 False True 2501406.4770982824 3355315.3324221973 3612655.6466526072 1.0 1.3413714896566824 1.4442497369893326 21.25430808299847 -12.482136008060175 0.18975510127207668 7.989477136555915e-11 1.5239324150219593 0.9994438468584572 0.004477824243455099 6.591698918024822 0.12617849330501146 2.584765765928088 0.0705644447474686 3.2950650442206073e-13 12.482136008060175 1.5239324149420646 HDVGAYMLMYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HDVGAYMLMYK 11 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 7885100.0 1908000.0 3202900.0 2774200.0 False True 2613439.1617612354 3061385.2874260773 2118991.0964424564 1.0 1.1714010152671641 0.8108055957248443 21.31751814452136 -6.77744255866768 1.545704809456542 1.097375275636042 0.8081690769239348 0.7582585624502133 0.07240962536231722 0.25458050063786686 1.2011927813650263 0.03690237815885254 0.08726682853922865 1.6693885918805632e-07 6.77744255866768 -0.2892061987121072 HDVVFLITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HDVVFLITK 9 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 24179200.0 7583000.0 5012200.0 11584000.0 False True 9941386.433876457 4264399.29740258 10385398.801574314 1.0 0.42895418317822676 1.0446630226730582 23.245015634572173 -11.957979386372502 18.310335371561244 0.9130159051682343 0.7631277426330858 0.0 0.28696256902019673 0.0 0.0 0.0 0.08344124973468102 1.1015915949395474e-12 11.957979386372502 -0.14988816253514847 HDVVFLITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HDVVFLITK 9 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 15705100.0 7583000.0 3760400.0 4361700.0 False True 10386640.022869734 3594253.0940201133 3331556.2920312425 1.0 0.346045794030229 0.32075399596940724 23.308225696095064 HEAK(ub)VNALDNLGQTSLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HEAKVNALDNLGQTSLHR 18 1 Q9H2K2 Q9H2K2 TNKS2 Tankyrase-2 1 14655000.0 3840200.0 3917400.0 6897400.0 True False 3718294.953019202 5481638.248971122 5090764.022435369 1.0 1.4742343784535195 1.3691124794448437 21.82620978562251 -10.08251665709934 4.783842390517602 0.9999861164807894 1.421673428937185 0.9554641648995602 0.042915835622449716 29821419.24425786 0.15320754536216252 5654.533478579536 0.014691232018165938 8.269577904991918e-11 10.08251665709934 0.4216873124563957 HEAK(ub)VNALDNLGQTSLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HEAKVNALDNLGQTSLHR 18 1 Q9H2K2 Q9H2K2 TNKS2 Tankyrase-2 1 13648700.0 3840200.0 4493400.0 5315100.0 True False 3193296.4497053074 4469193.162329929 6426462.835754259 1.0 1.3995547337117316 2.0124855104972554 21.606615061056786 -6.964881961765974 0.3600775290966793 0.9472305038012113 2.4858165121271107 0.9999106851698613 0.003935189902083127 0.07800109300535699 0.015001676830017739 0.008222084963999645 0.05234955353774081 1.0842215578928396e-07 6.964881961765974 1.5385860083258995 up HEANNPQLK(ub)EGLQNMEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HEANNPQLKEGLQNMEAR 18 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 17391700.0 8696500.0 5472300.0 3222900.0 True False 8420434.36772342 7657417.927667507 2378725.8050724864 1.0 0.909385144906461 0.2824944297636759 23.00546322589341 -6.932901704868132 0.7225746779253126 1.008582653918485 0.14373957958179678 0.9970784770232051 0.017243888401530766 0.09115885520927203 0.07050202002758475 0.015990505080629998 0.055845334356877864 1.167073734359676e-07 6.932901704868132 -0.8648430743366882 down HEANNPQLK(ub)EGLQNMEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HEANNPQLKEGLQNMEAR 18 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 15495300.0 5636900.0 6818200.0 3040200.0 True False 7721014.261494709 6516949.379227722 2322167.3748844177 1.0 0.844053534744554 0.3007593686836255 22.880358947117276 -6.948050122613487 0.5798546080054912 1.0064977546534848 0.11144962523973408 0.9990392545801223 0.009289723207901064 0.08427827803078751 0.03927641722351645 0.009734733514249985 0.04538269052610279 1.1270673720399017e-07 6.948050122613487 -0.8950481294137507 down HECSDK(ub)LAQCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HECSDKLAQCR 11 1 H3BSJ2;H3BTD0;H3BU00;H3BQ29;H3BUJ2;Q32MH5-2;Q32MH5;Q32MH5-3 H3BSJ2 FAM214A Protein FAM214A 1 2782370.0 821510.0 579560.0 1381300.0 True False 1063460.8893830604 547306.9765258147 1129917.5733348706 1.0 0.514647018982824 1.0624909525261088 20.02033554598839 -6.672918021718944 1.9272003489586762 0.6909822172393835 1.0603002913610695 0.2920136615493326 0.20602950181023555 0.45441985753440123 3.256620426347085 0.08598434574207912 0.22884374063682605 2.123645287632345e-07 6.672918021718944 0.36931807412168605 HEDANK(ub)AVEEMNGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HEDANKAVEEMNGK 14 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 6546900.0 2054100.0 2720500.0 1772300.0 True False 2692944.9919326967 2314612.004425944 1588919.397102052 1.0 0.8595095745957931 0.5900303949252608 21.36075332991889 -6.960854046194742 0.4232263183197383 1.0115057760289743 0.427814784673703 0.999800571098489 0.002402251280401842 0.0793974485116794 0.020014499712509733 0.0034937097074199414 0.02241258486953432 1.0943240751282931e-07 6.960854046194742 -0.5836909913552712 HEDANK(ub)AVEEMNGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HEDANKAVEEMNGK 14 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 5998800.0 1823900.0 2024200.0 2150700.0 True False 1766001.292852383 2832473.61606355 1587367.1503830089 1.0 1.6038910206507484 0.8988482379982573 20.75205496847762 -6.679903978269791 1.9018575359218475 1.3821085225231606 0.9015070742530163 0.32388080160450217 0.25594636300332163 0.43871622523324033 3.067862405613826 0.10798017908392485 0.2848642405245138 2.0897581215481881e-07 6.679903978269791 -0.4806014482701443 HEDANK(ub)AVEEMNGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HEDANKAVEEMNGK 14 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 6246200.0 1823900.0 3090100.0 1332200.0 True False 1516653.662470056 3073453.017963177 1610756.8606031528 1.0 2.0264699146657406 1.0620465967027952 20.532460243911896 -6.63144117672351 2.074903558601927 1.6755287735279325 1.0659226235549624 0.12281844600659075 0.44013739511413064 0.5552598163885408 4.557310398782716 0.17336839699550105 0.4876293695350238 2.336462544358286e-07 6.63144117672351 -0.6096061499729701 HEDANK(ub)AVEEMNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HEDANKAVEEMNGK 14 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 23610900.0 3304500.0 6029400.0 14277000.0 True False 4277740.391433243 5693858.589731442 11678732.494390748 1.0 1.3310435109933667 2.7301171706864213 22.028417499850374 -6.943612224779253 0.6250541600343752 0.9847268527784887 3.1511997651148107 0.9985997954931568 0.028058387212871017 0.08615664928188299 0.04739046837479753 0.028128047682830212 0.11863371314696022 1.1386435102846881e-07 6.943612224779253 2.1664729123363218 up HEDAQK(ub)AVDEMNGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HEDAQKAVDEMNGK 14 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 9034600.0 2853700.0 3867200.0 2313700.0 True False 3741228.3352701077 3290228.8342275377 2074300.5185775647 1.0 0.8794514900919542 0.554443710110467 21.835080588703715 -6.953824344140786 0.5151536792844775 1.0057369396222284 0.4137738578879755 0.999468221113252 0.004339332721089205 0.08198551281481857 0.029881296108179085 0.004954722236335217 0.026834002761842238 1.1121814720916285e-07 6.953824344140786 -0.5919630817342529 HEDAQK(ub)AVDEMNGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HEDAQKAVDEMNGK 14 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 8019000.0 3200200.0 2353100.0 2465700.0 True False 3098611.4027009187 3292705.1012543933 1819859.2005855674 1.0 1.0626389286453577 0.5873144334908466 21.563190407001127 -6.8737162817962725 1.114189006555323 1.0363658161810396 0.5574306049935924 0.9682563761886581 0.03756879761532593 0.1333445790824476 0.3071297206417988 0.02610366203139876 0.062235507887292166 1.3374689800375218e-07 6.8737162817962725 -0.4789352111874472 HEDAQK(ub)AVDEMNGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HEDAQKAVDEMNGK 14 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 31937300.0 6317700.0 9643600.0 15976000.0 True False 9584412.785737135 7922624.234209291 12818336.597470442 1.0 0.8266155070031204 1.3374149135715243 23.192258613418275 -6.815106473317038 1.392810909965087 0.9060592757607657 1.347447282825696 0.872780517712666 0.0756467566983994 0.199916120644978 0.7633078508402646 0.04269274122433328 0.09855592108252903 1.5307121403601083e-07 6.815106473317038 0.4413880070649303 HEDAQK(ub)AVDEMNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HEDAQKAVDEMNGK 14 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 7541800.0 2853700.0 2457200.0 2230900.0 True False 3908790.0083427853 2348632.7791262134 1704007.366827728 1.0 0.6008592874299651 0.43594241777909637 21.898290650226606 -13.999999999999995 0.121368796136775 2.900610501845541 0.177514982791245 0.9996862524485571 0.004194430880084965 11.95871332530007 0.10739156376668064 5.472533322067267 0.2293521416747898 1.0000000000000123e-14 13.999999999999995 -2.7230955190542963 HEDAQK(ub)AVDEMNGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 HEDAQKAVDEMNGK 14 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 13866970.0 4888600.0 6430110.0 2548260.0 True False 4065087.5017002686 6395469.7211531 3081089.384176993 1.0 1.5732674188386162 0.7579392529406298 21.95485497621498 -6.717717471002651 1.7673004076893573 1.3496069267504176 0.7593488448860306 0.5018571831678962 0.24130219460797456 0.3597559938958427 2.1946622684058235 0.10846003725120852 0.273032418848087 1.915501643736058e-07 6.717717471002651 -0.590258081864387 HEDAQK(ub)AVDEMNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HEDAQKAVDEMNGK 14 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 30256800.0 6317700.0 8434100.0 15505000.0 True False 8178387.19048503 7964734.920830252 12683249.094734779 1.0 0.9738759898891376 1.5508252176530397 22.963384935510724 -6.896295638006464 0.9843924903491529 0.9735131316376927 1.6070282552235828 0.9846308913166495 0.03298067967375083 0.11418465037940169 0.19319923153018406 0.025292477269271425 0.06466483662615506 1.2697094795027935e-07 6.896295638006464 0.6335151235858901 HEEAPGHRPTTNPNASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HEEAPGHRPTTNPNASK 17 1 P21291;E9PS42;E9PND2;E9PP21 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 112766900.0 6668900.0 57225000.0 48873000.0 False True 8742992.481719473 48687253.06130288 43816090.782919616 1.0 5.568717251341798 5.011566791866023 23.0596957277248 -10.189607587422392 4.948068822852546 0.9995806334769624 5.290142021611322 0.9875088078544987 0.22745572263779243 0.0010523507495937541 0.00017235380822945147 0.22024942379121082 0.07341101881098125 6.462378821778402e-11 10.189607587422392 4.29056138813436 HEEAPGHRPTTNPNASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HEEAPGHRPTTNPNASK 17 1 P21291;E9PS42;E9PND2;E9PP21 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 69230000.0 25637000.0 11487000.0 32106000.0 False True 24823167.467984315 16073819.003913628 23696475.440645766 1.0 0.6475329558423533 0.954611270749726 24.56518388116214 -10.181023396419576 7.431683801743502 1.000000163049889 0.8010721132960397 0.35878562059333785 0.12536419709945867 3.386190981908343e-07 3.7481199869943935e-08 0.1213834613747478 0.04046112063140563 6.591383850219733e-11 10.181023396419576 -0.19892804975384926 HEEAPGHRPTTNPNASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HEEAPGHRPTTNPNASK 17 1 P21291;E9PS42;E9PND2;E9PP21 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 51565600.0 3455900.0 45171000.0 2938700.0 False True 5242852.960132478 37109882.12736614 2357864.6569220335 1.0 7.078184799298365 0.4497293124281049 22.321920654247222 -6.665570207573099 1.9529797601577097 4.894501329686755 0.47704696677946223 0.25945045225421814 2.584579087843917 0.47148528507428894 3.4625205523566627 1.0670169046461533 2.867471782332723 2.1598808425650852e-07 6.665570207573099 -4.417454362907293 HEEAPGHRPTTNPNASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HEEAPGHRPTTNPNASK 17 1 P21291;E9PS42;E9PND2;E9PP21 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 98386900.0 6668900.0 41049000.0 50669000.0 False True 9134572.55024608 39235319.44910951 38702025.76081132 1.0 4.295255112736778 4.236873214146042 23.122905789247692 -10.1263983464325 4.673964334012698 0.9997314890260723 4.266064163484924 0.9997604124566596 0.023834310456745323 4158525.726301781 6.54960505434849 12069.295766439845 0.008159118400284687 7.474835741989109e-11 10.1263983464325 3.266332674458852 HEEAPGHRPTTNPNASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HEEAPGHRPTTNPNASK 17 1 P21291;E9PS42;E9PND2;E9PP21 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 33797200.0 25637000.0 5909700.0 2250500.0 False True 21318301.411669973 5877863.273116392 2721069.1448636837 1.0 0.2757191184987542 0.12764005406988607 24.345589156596418 -13.999999999999998 0.2231447331930619 5.431854056197818 0.05078015166996138 0.9995012380445284 0.008512356832143677 13.087087264609984 0.1496225629267642 25.600771502127245 0.08028380668762894 1.0000000000000041e-14 13.999999999999998 -5.381073904527857 HEEAPGHRPTTNPNASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HEEAPGHRPTTNPNASK 17 1 P21291;E9PS42;E9PND2;E9PP21 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 11695400.0 3455900.0 3567700.0 4671800.0 False True 4473730.675973409 3369154.3587396513 3821580.3367160307 1.0 0.7530972699885604 0.8542267323422457 22.09304697633967 -10.04885964378657 5.578045037718801 1.0000009716287002 0.8036620012096937 0.8340427403963593 0.041285930121720334 4.988857162083242e-07 8.500474610145025e-08 0.039975127706225154 0.013324976649465426 8.935942307540081e-11 10.04885964378657 -0.1963389704190065 HEGVSCDACLK(ub)GNFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HEGVSCDACLKGNFR 15 1 Q9P0J7 Q9P0J7 KCMF1 E3 ubiquitin-protein ligase KCMF1 1 6733800.0 2126300.0 2248100.0 2359400.0 True False 2787599.8911184925 1912692.243025164 2115271.9209629158 1.0 0.6861430326206959 0.758814752325947 21.41059207295413 -9.966879210844288 5.539424142650314 1.0000005252931994 0.722478892472913 0.9510874220478268 0.029668105336179383 1.924478015203315e-07 3.59323434389179e-08 0.028726073830738736 0.009575339823169934 1.0792468485133238e-10 9.966879210844288 -0.2775216328202864 HEGVSCDACLK(ub)GNFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HEGVSCDACLKGNFR 15 1 Q9P0J7 Q9P0J7 KCMF1 E3 ubiquitin-protein ligase KCMF1 1 5913300.0 2617200.0 1428200.0 1867900.0 True False 2534118.4185828506 1998487.707964611 1378640.954201154 1.0 0.7886323280354912 0.5440317800823721 21.273052512078536 -6.96920997188493 0.2764046978543932 1.0562733521603063 0.26897364551352515 0.9999755471321496 0.0009212966354140955 0.07655988310299391 0.009944191482351804 0.004613720685873999 0.02255497705423788 1.0734702874490552e-07 6.96920997188493 -0.7872997066467811 HEGVSCDACLK(ub)GNFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HEGVSCDACLKGNFR 15 1 Q9P0J7 Q9P0J7 KCMF1 E3 ubiquitin-protein ligase KCMF1 1 25126800.0 5966000.0 7986800.0 11174000.0 True False 9050858.173023043 6561493.138846779 8965454.002261812 1.0 0.7249581214744855 0.9905639698326302 23.109623159671095 -10.689710920688878 9.025791169158767 1.0002251200201462 0.8577610457039351 0.27661239332790455 0.10843313352941661 0.0004919724332616176 1.691301698737064e-05 0.10515380583491483 0.03499664336137629 2.0430974385201604e-11 10.689710920688878 -0.1424640743162111 HEGVSCDACLK(ub)GNFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HEGVSCDACLKGNFR 15 1 Q9P0J7 Q9P0J7 KCMF1 E3 ubiquitin-protein ligase KCMF1 1 6994100.0 2126300.0 1979400.0 2888400.0 True False 2912450.5710969185 1891943.5629995246 2206219.408465285 1.0 0.6496053810406679 0.7575130820621463 21.473802134477022 -10.552482049363924 9.243014081062691 1.0000216532560338 0.7035592315514073 0.9096052423645851 0.0440531344699042 1.965834522830103e-05 9.517809362415128e-07 0.04265737019571335 0.014218088012514582 2.8023214472528067e-11 10.552482049363924 -0.29646242170462644 HEGVSCDACLK(ub)GNFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HEGVSCDACLKGNFR 15 1 Q9P0J7 Q9P0J7 KCMF1 E3 ubiquitin-protein ligase KCMF1 1 8538300.0 2617200.0 1894200.0 4026900.0 True False 2176317.7616188573 1883995.5686307373 4868906.171718088 1.0 0.8656803716150918 2.2372220902596247 21.053457787512812 -6.882841117424379 1.0638597995006849 0.9131689329785605 2.3398642925381106 0.9759044876855215 0.09582674350005166 0.12514171399445306 0.25734815865748745 0.06920120500741411 0.16861732414823488 1.3096609625860317e-07 6.882841117424379 1.4266953595595502 up HEGVSCDACLK(ub)GNFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HEGVSCDACLKGNFR 15 1 Q9P0J7 Q9P0J7 KCMF1 E3 ubiquitin-protein ligase KCMF1 1 18809600.0 5966000.0 8645000.0 4198600.0 True False 7723104.607441574 8163898.150434254 3434497.881274008 1.0 1.0570746565530078 0.44470430686186846 22.880749481763544 -6.884085407224837 1.056718322892307 1.0377179236362273 0.3977512960287529 0.9768355156207734 0.042038244777021345 0.1240742211201031 0.2509219364235966 0.030522597042314126 0.07464266155537598 1.3059140452133014e-07 6.884085407224837 -0.6399666276074744 down HEHQVMLMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HEHQVMLMR 9 0 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 36812500.0 9096500.0 14345000.0 13371000.0 False True 11925599.5906313 12204781.916372035 11987497.183688732 1.0 1.0234103387103537 1.0051903128716528 23.507558467522763 -6.583001708673164 2.2549555208989975 1.0159125274056833 1.0052372145827786 0.0 0.010162344006240243 0.6903169529324075 6.60637611039741 0.0037769863702735327 0.011352152318711383 2.6121510772222856e-07 6.583001708673164 -0.010675312822904681 HEHQVMLMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HEHQVMLMR 9 0 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 5162600.0 1348300.0 1035600.0 2778700.0 False True 1305498.9545221056 1449120.4805826552 2050875.1107868406 1.0 1.1100127468988468 1.5709511705718595 20.316169871627263 -6.9438110411953105 0.6231070235786569 0.9949642573639734 1.7105495679093838 0.9986216052676199 0.009182580458548447 0.0860703570285613 0.0470108781818731 0.009221528452980321 0.03905548647120209 1.1381223680147743e-07 6.9438110411953105 0.7155853105454104 HEHQVMLMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HEHQVMLMR 9 0 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 31547700.0 9096500.0 9640200.0 12811000.0 False True 12459721.873669324 9214264.088121658 9785305.650827013 1.0 0.7395240585260435 0.7853550624999056 23.570768529045655 -10.392274448845649 5.8719909439923725 1.0000641527366272 0.7624395605129798 0.9728434396570588 0.01871042902257257 1.5718205764580346e-05 1.6267629254631046e-06 0.018121173595199224 0.0060387650004014954 4.0525235859910796e-11 10.392274448845649 -0.2376245922236474 HEHQVMLMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HEHQVMLMR 9 0 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 3220780.0 1348300.0 1034900.0 837580.0 False True 1121171.1898176307 1029324.7882884333 1012714.1054676389 1.0 0.9180799485722274 0.9032644743862591 20.09657514706154 -13.999999999999998 0.24051603941284586 1.5435913488715545 0.8967458583383351 0.9995258014212334 0.000926374060642185 13.641655149338096 0.15521726987675252 3.562688674478665 0.0072174967994065725 1.0000000000000041e-14 13.999999999999998 -0.6468454905332194 HEIEGTGLPQAQLLWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HEIEGTGLPQAQLLWR 16 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 0 5702900.0 1387500.0 2106700.0 2208700.0 False True 1819025.9365691154 1792388.5718522836 1980164.9113464425 1.0 0.9853562479889248 1.0885853090590083 20.79473468311779 -6.870958859823733 1.1290633826928027 0.9916686554288037 1.0947407314774396 0.9656281919975903 0.008454929087149331 0.13593605578090628 0.32329879496215075 0.005808359326935285 0.013774351885496024 1.345987851772594e-07 6.870958859823733 0.10307207604863589 HEIEGTGLPQAQLLWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HEIEGTGLPQAQLLWR 16 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 0 5476000.0 1387500.0 1415500.0 2673000.0 False True 1900496.245777631 1352958.529567456 2041692.4521630316 1.0 0.7118975018095143 1.0742943884783245 20.857944744640683 -6.694896777831071 1.8486678239520868 0.8202069578988286 1.0731295351084469 0.3933970201326321 0.12173022004620972 0.40633666414204417 2.6959688737423555 0.05259943676271885 0.13615071424070155 2.018846141627897e-07 6.694896777831071 0.2529225772096183 HEILLSQSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HEILLSQSVR 10 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 9299200.0 3248300.0 3249400.0 2801500.0 False True 4258552.756581947 2764602.186061995 2511627.6538855718 1.0 0.6491881970439541 0.5897843228556092 22.02193179187685 -13.999999999999998 0.24986029434312057 3.4380160204733934 0.5658672002549022 0.9995424258517351 0.003871931958417778 13.99251167397658 0.15817378769408358 17.120549611044922 0.027435945669677813 1.0000000000000041e-14 13.999999999999998 -2.872148820218491 HEILLSQSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HEILLSQSVR 10 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 4188250.0 949820.0 797730.0 2440700.0 False True 919668.4840051824 1116267.7491069932 1801407.450569493 1.0 1.2137718846748073 1.958757402150297 19.810754376177865 -6.948042817592246 0.5799315468365321 0.9910926047612495 2.2182805970007693 0.9990386159877558 0.012741987360739412 0.08428127895487394 0.039289060930998994 0.013351260907651897 0.062231774385806946 1.127086329960573e-07 6.948042817592246 1.2271879922395197 HEILLSQSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HEILLSQSVR 10 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 6842500.0 3248300.0 1902200.0 1692000.0 False True 4449284.292006827 1818154.5142657857 1292384.4478338393 1.0 0.408639771014883 0.29047018868981195 22.08514185339974 -13.999999999999998 0.22638151466904063 4.671649831779514 0.23100060552845966 0.9995050714386282 0.006905344143958233 13.181148553123744 0.15067826235189222 21.70998095694869 0.06275166338055657 1.0000000000000041e-14 13.999999999999998 -4.440649226251055 HEILLSQSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HEILLSQSVR 10 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 2858600.0 949820.0 1117200.0 791580.0 False True 789817.4141604858 1111181.421853162 957095.7181476086 1.0 1.406883922702896 1.2117936386157382 19.59115965161214 -10.12837229977533 4.514799021054741 0.9999667331593584 1.3093387805784593 0.7702337017795513 0.07964527501036542 2.8790944033694763e-05 5.558548791973578e-06 0.07712514751145687 0.025705401970038847 7.440938245632867e-11 10.12837229977533 0.30937204741910096 HEIVPK(ub)DIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HEIVPKDIR 9 1 H0YJ03;P25788-2;P25788;G3V4X5 H0YJ03;P25788-2 PSMA3 Proteasome subunit alpha type-3 1 12635400.0 4892800.0 5376400.0 2366200.0 True False 6414508.181942596 4574262.077043056 2121368.3221931234 1.0 0.7131118937411297 0.33071410340779694 22.6129072234664 -7.015932799317419 0.32707818891929163 1.0497900947307899 1.0971459029577249e-13 0.9999488086537013 0.001961559501392666 0.07302848042904934 0.01262741705594811 0.005699622305880255 0.03184562298268053 9.63978173526483e-08 7.015932799317419 -1.0497900947306802 down HEIVPK(ub)DIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HEIVPKDIR 9 1 H0YJ03;P25788-2;P25788;G3V4X5 H0YJ03;P25788-2 PSMA3 Proteasome subunit alpha type-3 1 19474000.0 7482700.0 5269600.0 6721700.0 True False 7245165.784322901 7373778.760600968 4961085.123322383 1.0 1.0177515573979494 0.6847441826738023 22.7885872713195 -6.894311611654344 0.996506563798964 1.016087640322729 0.6535585707645781 0.9835182169254935 0.019638355591297167 0.11571531125387677 0.20196076914190533 0.01492402189015283 0.03783311742286452 1.2755232766939587e-07 6.894311611654344 -0.3625290695581509 HEIVPK(ub)DIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HEIVPKDIR 9 1 H0YJ03;P25788-2;P25788;G3V4X5 H0YJ03;P25788-2 PSMA3 Proteasome subunit alpha type-3 1 63028000.0 25370000.0 20800000.0 16858000.0 True False 38488144.79543997 17088077.48885823 13526008.910876133 1.0 0.44398288303266836 0.35143312266063487 25.197910796287186 -13.999999999999998 0.25229988842588935 4.912108079300813 0.31502603736548185 0.9995470589492598 0.006095836666215682 14.090345621395572 0.15894082417239175 27.974954857254353 0.042171919132827355 1.0000000000000041e-14 13.999999999999998 -4.597082041935331 HEIVPK(ub)DIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HEIVPKDIR 9 1 H0YJ03;P25788-2;P25788;G3V4X5 H0YJ03;P25788-2 PSMA3 Proteasome subunit alpha type-3 1 13179300.0 4892800.0 5632700.0 2653800.0 True False 6701800.382948307 5383828.689151975 2027027.0967266203 1.0 0.8033406519911117 0.3024600825002303 22.676117284989292 -6.955061651280735 0.5001992199484111 1.0100137785511234 0.07417622475517358 0.999540961360772 0.006291687051811314 0.08151466583679831 0.028026677918111823 0.0073757637948279635 0.041318396074558006 1.1090173709536831e-07 6.955061651280735 -0.9358375537959498 down HEIVPK(ub)DIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HEIVPKDIR 9 1 H0YJ03;P25788-2;P25788;G3V4X5 H0YJ03;P25788-2 PSMA3 Proteasome subunit alpha type-3 1 19669500.0 7482700.0 10357000.0 1829800.0 True False 6222196.589815614 10301204.78529646 2212402.7199607035 1.0 1.655557589124924 0.35556618760357506 22.568992546753776 -6.769596541559756 1.5759301505664076 1.3761997876287249 0.3483526194623197 0.7290528534796834 0.27625646167707146 0.26707535914943303 1.3089669248255573 0.1381772884449255 0.3290502701453439 1.6998220494325326e-07 6.769596541559756 -1.0278471681664052 HEIVPK(ub)DIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HEIVPKDIR 9 1 H0YJ03;P25788-2;P25788;G3V4X5 H0YJ03;P25788-2 PSMA3 Proteasome subunit alpha type-3 1 64196000.0 25370000.0 22096000.0 16730000.0 True False 32841965.11746446 20866338.17605495 13685311.664296247 1.0 0.6353559569722216 0.4167019730807391 24.969037118379635 -9.142695767921552 0.13738943166695922 1.5552728807797038 2.8644158982458182e-11 0.9998745587604376 0.0026947690020117537 0.5935192281916954 0.04706437020665148 0.3169642631038217 0.18573141761985915 7.199531431489873e-10 9.142695767921552 -1.5552728807510596 HEK(ub)EIDAYIVQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HEKEIDAYIVQAK 13 1 E5RGS2;Q9H6H4;Q9H6H4-2 E5RGS2 REEP4 Receptor expression-enhancing protein;Receptor expression-enhancing protein 4 1 19766400.0 4128900.0 6466100.0 9171400.0 True False 5413027.884324484 5501383.08466039 8222431.50628096 1.0 1.0163226944741544 1.519007786767955 22.368004389202525 -6.913811657608006 0.8693821182131197 0.9862485143942581 1.5895584050123477 0.992282008076279 0.02116422967796311 0.10195124711332539 0.1254970110322448 0.01766081531425989 0.050140302435778404 1.2195183581348818e-07 6.913811657608006 0.6033098906180896 HEK(ub)EIDAYIVQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HEKEIDAYIVQAK 13 1 E5RGS2;Q9H6H4;Q9H6H4-2 E5RGS2 REEP4 Receptor expression-enhancing protein;Receptor expression-enhancing protein 4 1 13040500.0 4399900.0 3600700.0 5039900.0 True False 4260227.582883492 5038478.287402438 3719798.996240905 1.0 1.182678199551066 0.8731456063957965 22.022499071119753 -6.746808520777978 1.6618801896869269 1.107828470277989 0.8726852979618721 0.6350372638490552 0.0767532257494748 0.30564217668912597 1.659850455887867 0.03650144627819713 0.08890684855443297 1.7913955012104883e-07 6.746808520777978 -0.23514317231611692 HEK(ub)EIDAYIVQAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HEKEIDAYIVQAK 13 1 E5RGS2;Q9H6H4;Q9H6H4-2 E5RGS2 REEP4 Receptor expression-enhancing protein;Receptor expression-enhancing protein 4 1 49003500.0 15543000.0 25772000.0 7688500.0 True False 23579867.345507447 21172785.24244491 6168864.605010733 1.0 0.8979179115898993 0.2616157467987646 24.491052266307122 -6.935033035900308 0.7042531148592773 1.008110014951063 0.11249891419030804 0.997438274990438 0.016534706266496137 0.09010735304763089 0.0654859227079288 0.015543642702012727 0.056066943200097856 1.1613602681603704e-07 6.935033035900308 -0.8956111007607549 down HEK(ub)EIDAYIVQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HEKEIDAYIVQAK 13 1 E5RGS2;Q9H6H4;Q9H6H4-2 E5RGS2 REEP4 Receptor expression-enhancing protein;Receptor expression-enhancing protein 4 1 16459300.0 4128900.0 6076800.0 6253600.0 True False 5655465.909327034 5808306.882709658 4776628.476934815 1.0 1.0270253549102926 0.8446038847227716 22.431214450725417 -6.869223890269457 1.1382678662013912 1.015213506701302 0.83408018568187 0.9638985625857653 0.015273476810813645 0.1375972704418648 0.33369691968363213 0.010418842275883427 0.02463301686803038 1.3513757137349802e-07 6.869223890269457 -0.18113332101943191 HEK(ub)EIDAYIVQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HEKEIDAYIVQAK 13 1 E5RGS2;Q9H6H4;Q9H6H4-2 E5RGS2 REEP4 Receptor expression-enhancing protein;Receptor expression-enhancing protein 4 1 12160700.0 4399900.0 4645900.0 3114900.0 True False 3658711.798619442 4620871.614561052 3766211.1883296524 1.0 1.2629777552592871 1.0293817593806578 21.80290434655403 -10.586429872637956 3.0991696509164957 0.9923644815406207 1.1461797574893084 0.34302783995057606 0.09536516663366937 34629385.01795004 33167193.753067814 2120445.3381025484 0.03490006322974732 2.591612866231835e-11 10.586429872637956 0.1538152759486877 HEKEDGAISTIVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HEKEDGAISTIVLR 14 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 10939800.0 2995800.0 4616500.0 3327500.0 False True 3927522.811368466 3927736.1949760546 2983202.219633848 1.0 1.0000543303292782 0.7595633081999622 21.905188224156845 -6.906842843076798 0.9169730104494196 1.008209772120812 0.7304952758355242 0.9896744487557108 0.01151861146734782 0.10654276304504325 0.15036856755139769 0.009285637857345175 0.02510487125059436 1.2392449474870831e-07 6.906842843076798 -0.2777144962852879 HEKEDGAISTIVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HEKEDGAISTIVLR 14 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 15156200.0 2995800.0 7006400.0 5154000.0 False True 4103428.218450895 6696834.08093355 3936731.349961941 1.0 1.6320095599141988 0.9593761948267041 21.968398285679736 -6.660239524942895 1.972209808815561 1.406745528605256 0.9621911858804296 0.23652232520021377 0.26908177362285296 0.4838970179632482 3.618512160982327 0.11022435589059991 0.2982659177362053 2.1865553479778253e-07 6.660239524942895 -0.4445543427248263 HELLLGAGSGPGAGQQQATPGALLQAGPPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HELLLGAGSGPGAGQQQATPGALLQAGPPR 30 0 Q96DI7;Q96DI7-2 Q96DI7 SNRNP40 U5 small nuclear ribonucleoprotein 40 kDa protein 0 17262600.0 3507700.0 8232500.0 5522400.0 False True 4598628.668615118 7004243.090033659 4950995.02260134 1.0 1.5231156057101245 1.0766242241716677 22.132772276592778 -9.942150457145633 4.357952836266417 0.9999929116148979 1.2998699144577965 0.37555446397543435 0.18227934364078274 125886536.45736623 328772635.4627986 15141.95656615719 0.06670740814549278 1.1424824641611534e-10 9.942150457145633 0.29987700284289864 HELLLGAGSGPGAGQQQATPGALLQAGPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HELLLGAGSGPGAGQQQATPGALLQAGPPR 30 0 Q96DI7;Q96DI7-2 Q96DI7 SNRNP40 U5 small nuclear ribonucleoprotein 40 kDa protein 0 16237600.0 5214600.0 2828100.0 8194900.0 False True 5049065.377327723 3957375.078346673 6048409.848269727 1.0 0.7837836871981958 1.197926625277908 22.267584927429343 -6.764828779554743 1.5941365646274246 0.8751643282605346 1.1998193160038133 0.7103950376286681 0.09101621249335803 0.2748948758357926 1.377792713624934 0.04502437426985267 0.10769799364795878 1.7185858054563222e-07 6.764828779554743 0.3246549877432787 HELLLGAGSGPGAGQQQATPGALLQAGPPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HELLLGAGSGPGAGQQQATPGALLQAGPPR 30 0 Q96DI7;Q96DI7-2 Q96DI7 SNRNP40 U5 small nuclear ribonucleoprotein 40 kDa protein 0 24887200.0 3240400.0 15439000.0 6207800.0 False True 4915923.704972162 12683789.824542413 4980825.609024609 1.0 2.580143750342081 1.0132023822881553 22.229031094613177 -6.64428407745747 2.0294024370735286 2.029986818228567 1.0198210040646691 0.1710353942728018 0.6753854419749346 0.522681256382497 4.1194395321285135 0.2705523905682273 0.7477405207432968 2.2683805903581076e-07 6.64428407745747 -1.010165814163898 HELLLGAGSGPGAGQQQATPGALLQAGPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HELLLGAGSGPGAGQQQATPGALLQAGPPR 30 0 Q96DI7;Q96DI7-2 Q96DI7 SNRNP40 U5 small nuclear ribonucleoprotein 40 kDa protein 0 17104300.0 3507700.0 5883200.0 7713400.0 False True 4804591.482028241 5623260.770859255 5891653.782459536 1.0 1.1703931108176997 1.2262548864971128 22.19598233811567 -13.999999999999998 0.15591066042895457 0.16767909761738534 1.2837251686726625 0.9995477225320974 0.00204654309767715 11.984879270068603 0.124628811170221 3.0180115490328845 0.05212321975053585 1.0000000000000041e-14 13.999999999999998 1.116046071055277 HELLLGAGSGPGAGQQQATPGALLQAGPPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HELLLGAGSGPGAGQQQATPGALLQAGPPR 30 0 Q96DI7;Q96DI7-2 Q96DI7 SNRNP40 U5 small nuclear ribonucleoprotein 40 kDa protein 0 12641800.0 5214600.0 3017300.0 4409900.0 False True 4336170.9459489845 3001045.2060128436 5331989.700926177 1.0 0.6920956861298408 1.2296539429349584 22.04799020286362 -6.7513414916978025 1.6447076066168524 0.8192442377950188 1.2308443063906043 0.6548030562971383 0.1293932859651043 0.29770625723018185 1.5848279142327484 0.06213516928778236 0.1506457574881397 1.7727949597452112e-07 6.7513414916978025 0.4116000685955855 HELLQPFNVLYEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HELLQPFNVLYEK 13 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 77221400.0 13671400.0 30568000.0 32982000.0 False True 17923337.79402593 26007373.553130776 29569339.025684014 1.0 1.4510340569377291 1.6497674353679725 24.095335994156297 -11.277190335256654 0.14984350509655478 2.2122967436104182e-15 1.910237898540705 0.9996329390739362 0.0052083360208846664 3.7701423021906737 0.09172092730936092 1.450084171293238 0.18925539831674856 5.282137044509684e-12 11.277190335256654 1.9102378985407027 HELLQPFNVLYEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HELLQPFNVLYEK 13 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 69578200.0 20910300.0 14627900.0 34040000.0 False True 20246513.972219545 20468896.753490783 25123902.821889415 1.0 1.0109837565902147 1.2409001794759427 24.271170191570054 -6.916858789618344 0.847707330674821 0.9943302663172708 1.2754225875626362 0.9932626823920471 0.009116186434736693 0.10005546053026006 0.11545550891127765 0.007726561523467814 0.02249281698801198 1.2109918222261446e-07 6.916858789618344 0.2810923212453653 HELLQPFNVLYEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HELLQPFNVLYEK 13 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 114141000.0 27500000.0 73860000.0 12781000.0 False True 41719510.51929829 60679105.92918609 10254829.747888705 1.0 1.4544539275243322 0.24580417220247835 25.31421889552263 -6.8048363546161195 1.4359933402558602 1.2492223592632064 0.22703864156354614 0.8459634123826663 0.1956336156967174 0.2139177165763998 0.870279387030668 0.10715030389633799 0.24850548688124172 1.56734154477958e-07 6.8048363546161195 -1.0221837176996602 down HELLQPFNVLYEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HELLQPFNVLYEK 13 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 82675400.0 13671400.0 32986000.0 36018000.0 False True 18726086.035693172 31528569.44988495 27511290.21399481 1.0 1.6836710773297414 1.4691425726420593 24.15854605567919 -10.084949408677211 4.581713191551665 0.9999665423121267 1.5764068249413479 0.9058874989216159 0.0875808953843463 13756417.626539841 15175117.164207324 4186.927950485341 0.02998127013132565 8.22338439251459e-11 10.084949408677211 0.5764402826292212 HELLQPFNVLYEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HELLQPFNVLYEK 13 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 44468700.0 20910300.0 13989400.0 9569000.0 False True 17387840.933355805 13914036.325521527 11569833.657942936 1.0 0.8002164488881229 0.6653979468921901 24.05157546700433 -7.956636270867038 0.07408074305685604 1.5948930560614456 0.00016487920841017252 0.9999972977280829 0.0002258849304134283 0.11538500452824291 0.011546496355480902 0.11448195660124103 0.12762900159427762 1.1050036921520324e-08 7.956636270867038 -1.5947281768530355 HELLQPFNVLYEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HELLQPFNVLYEK 13 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 68252000.0 27500000.0 18528800.0 22223200.0 False True 35599292.10604145 17497655.991875768 18178805.629287962 1.0 0.4915169644316128 0.5106507616819407 25.085345217615078 -10.385379903807886 9.127148654315599 1.0000012254583694 0.5010838630716993 0.9988981310765571 0.007811340017528519 1.947831052628445e-07 1.3113626492701088e-08 0.00756331592796285 0.0025210991499542905 4.1173718994727376e-11 10.385379903807886 -0.49891736238667017 HELLSLASSNHLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HELLSLASSNHLGK 14 0 A0A087WZK9;B3KS98;O15372;E5RJT0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 0 13491300.0 3610800.0 4513900.0 5366600.0 False True 4733793.767036938 3840443.7150443876 4811315.712062214 1.0 0.8112824309725406 1.0163762827111498 22.17456542416009 -11.196124600833013 10.07091471479608 9.137920875065207 0.9138293568418432 0.1905262751627791 0.08372921435693617 0.04315615563338642 0.0008404400169905375 0.000228689121201629 0.027023487732953728 6.366128479186832e-12 11.196124600833013 -8.224091518223364 HELLSLASSNHLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HELLSLASSNHLGK 14 0 A0A087WZK9;B3KS98;O15372;E5RJT0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 0 15333300.0 3128000.0 3246300.0 8959000.0 False True 3028703.3521806356 4542564.519230859 6612369.135761079 1.0 1.4998380465225356 2.183234330625428 21.530268848911344 -6.966751495306792 0.32659806746482906 0.9133678671595399 2.791963292949126 0.9999448303857132 0.003602297422311643 0.07737152090710624 0.012790627832753575 0.010096316937765838 0.05977365123308718 1.0795642756653812e-07 6.966751495306792 1.878595425789586 HELLSLASSNHLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HELLSLASSNHLGK 14 0 A0A087WZK9;B3KS98;O15372;E5RJT0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 0 15586300.0 3610800.0 4037600.0 7937900.0 False True 4945810.33820098 3859205.4814422936 6063131.506182169 1.0 0.7802979122822703 1.225912659721523 22.23777548568298 -6.772638837823299 1.5642505998780896 0.8744088917460593 1.2286784945340021 0.7405704443817684 0.0926632897482244 0.26219307664747155 1.2664643468317172 0.04668175154040964 0.1108597796746972 1.687956157436594e-07 6.772638837823299 0.35426960278794284 HELQANCYEEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HELQANCYEEVK 12 0 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 0 84273000.0 12063000.0 41012000.0 31198000.0 False True 15814709.81825819 34893169.46352389 27969930.232347637 1.0 2.206374310026194 1.768602178211083 23.914763748514478 -10.147828143024642 4.865661526932001 0.9999295060068206 1.987488244122778 0.8715366422620615 0.17871972444052497 0.00013667810803432202 2.393814335880405e-05 0.17305687009660825 0.057681543031042795 7.114950074210906e-11 10.147828143024642 0.9875587381159573 HELQANCYEEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HELQANCYEEVK 12 0 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 0 25613500.0 12046000.0 3937500.0 9630000.0 False True 11663606.323647046 5509764.283791244 7107614.106192572 1.0 0.47238942492603075 0.6093839168578968 23.475510595186986 -10.2870473203578 8.46361204635652 1.0000004243898746 0.5408866708920217 0.9374029329442851 0.055927767134149806 4.4785907232312386e-07 3.775491269664804e-08 0.05415187770093682 0.018050609225094064 5.163601040485497e-11 10.2870473203578 -0.4591137534978529 HELQANCYEEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HELQANCYEEVK 12 0 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 0 105102000.0 11200000.0 88790000.0 5112000.0 False True 16991218.82967785 72944730.78056358 4101610.959330807 1.0 4.293084063702015 0.24139592341466964 24.01828600916821 -6.690565867754807 1.864388023528477 3.0635234251333543 0.2553477663967331 0.3729745120877235 1.392596250042808 0.41551884864909067 2.8007188121660676 0.5974431465100708 1.5546844214626454 2.0390793769176097e-07 6.690565867754807 -2.808175658736621 HELQANCYEEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HELQANCYEEVK 12 0 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 0 69198000.0 12063000.0 29873000.0 27262000.0 False True 16523017.090317521 28553112.08319936 20823277.078514263 1.0 1.7280810113021954 1.2602587629541757 23.97797381003737 -10.259146615223951 4.693723887028432 0.9998353676988165 1.4941698871296516 0.5980301210791559 0.19098763313406475 0.00032914176932757145 5.195121843798689e-05 0.18498398896456586 0.06164099353760572 5.506217784000978e-11 10.259146615223951 0.49433451943083506 HELQANCYEEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HELQANCYEEVK 12 0 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 0 20396700.0 12046000.0 2387800.0 5962900.0 False True 10016782.728282433 2374936.4474588116 7209714.820665477 1.0 0.23709573341879198 0.7197635225039686 23.255915870621262 -10.629035526649979 5.650795757585977 1.004178962173381 0.47842962796806565 0.6089053574728517 0.19704829975599603 0.010426347504100592 0.0006844705718013248 0.19175117055322677 0.06359706527945494 2.3494406213796634e-11 10.629035526649979 -0.5257493342053153 HELQANCYEEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HELQANCYEEVK 12 0 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 0 25363300.0 11200000.0 8730600.0 5432700.0 False True 14498620.785005968 8244734.435185802 4444004.344209337 1.0 0.5686564644626236 0.30651221313445143 23.78941233126066 -8.679670533986128 0.194568021393597 1.3530157934582547 1.1083546673839312e-23 0.9996942836326441 0.004999065394154939 0.2487641184429568 0.05453182770517487 0.1863744856184225 0.13397092619944923 2.0908817214217336e-09 8.679670533986128 -1.3530157934582547 down HELQANCYEEVK(ub)DR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HELQANCYEEVKDR 14 1 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 1 90551710.0 36002300.0 28477000.0 26072410.0 True False 47199363.94676914 24228342.6024766 23374687.11741662 1.0 0.5133192606112452 0.4952330955937945 25.492264082336263 HELQANCYEEVK(ub)DR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HELQANCYEEVKDR 14 1 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 1 55328540.0 31016900.0 14514740.0 9796900.0 True False 30032285.487292703 20310551.375369135 7230797.989299887 1.0 0.6762905668289202 0.24076748978559726 24.84001093383579 -7.276199936165166 0.3873421165098757 1.035026203830677 3.9549573037691636e-23 0.9996002847076328 0.0062192586960969215 0.09916031917108492 0.02904245887190611 0.01108682274382554 0.049755911886109006 5.294196588342433e-08 7.276199936165166 -1.035026203830677 down HELQANCYEEVK(ub)DR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HELQANCYEEVKDR 14 1 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 1 282541600.0 74138700.0 92155000.0 116247900.0 True False 112473828.16498555 75709220.23969853 93271451.6117355 1.0 0.6731274419560276 0.8292724906181509 26.745014095036787 -10.097836430831604 4.749452397430015 1.0000129141961103 0.751199966283874 0.7719597579032553 0.06374594919175497 60049295947.314575 11406296162.982422 8786784.684172114 0.0218219112063966 7.982952941517536e-11 10.097836430831604 -0.2488129479122363 HELQANCYEEVK(ub)DR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HELQANCYEEVKDR 14 1 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 1 82451000.0 36002300.0 25390700.0 21058000.0 True False 49313323.235574715 24268854.9181833 16084534.103123508 1.0 0.49213586361333905 0.3261701513460382 25.555474143859154 -13.999999999999998 0.15637587716357818 3.48296392443263 0.15631312363150843 0.9995463731577748 0.006105230737289557 11.98747368113829 0.12483361058708635 9.031443754380364 0.1541359511871133 1.0000000000000041e-14 13.999999999999998 -3.3266508008011213 HELQANCYEEVK(ub)DR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HELQANCYEEVKDR 14 1 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 1 65645300.0 31016900.0 12396000.0 22232400.0 True False 25791926.63165061 12329220.287586635 26881092.048996817 1.0 0.478026339934482 1.042228928179783 24.620416209270065 -11.982526522727031 14.609125426000332 0.9056967983987563 0.7841148706514194 0.0 0.26262739410557945 0.0 0.0 0.0 0.0763996239405016 1.0410545276117106e-12 11.982526522727031 -0.1215819277473369 HELQANCYEEVK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HELQANCYEEVKDR 14 1 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 1 292530800.0 74138700.0 104149200.0 114242900.0 True False 95974008.64226097 98353205.4654952 93451864.4311434 1.0 1.024790011971914 0.973720549482113 26.516140417129236 -6.774716174919186 1.5564525706703871 1.014133108087806 0.9733810225141541 0.7482498429830313 0.010462417504592704 0.25887265455948605 1.2382582091267698 0.005296506510544396 0.012553882752821746 1.679901527852489e-07 6.774716174919186 -0.04075208557365184 HELQANCYEEVKDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HELQANCYEEVKDR 14 1 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 0 162485000.0 17094000.0 87429000.0 57962000.0 False True 22410399.538531475 74384933.99557282 51964648.250764005 1.0 3.3192149862245235 2.318773842537623 24.417665034037967 -10.075096928543127 5.055814331185582 0.9999630168848254 2.8189944143820167 0.81508070359838 0.4084283866446028 0.00017652590908375437 3.2295222681775676e-05 0.3954673419508295 0.13181969496252832 8.412073747995408e-11 10.075096928543127 1.8190313974971914 HELQANCYEEVKDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HELQANCYEEVKDR 14 1 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 0 45913500.0 22462000.0 6461500.0 16990000.0 False True 21748956.105077162 9041610.646277357 12539809.310925422 1.0 0.4157261894591183 0.57657062942888 24.37444282111909 -10.638680178667029 10.028492807802058 1.0001198973003065 0.496148409444158 0.9289961316008335 0.06566446764827266 0.0001760669436444135 6.343514225520873e-06 0.06359398948307132 0.021193115803277963 2.2978401910964834e-11 10.638680178667029 -0.5039714878561485 HELQANCYEEVKDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HELQANCYEEVKDR 14 1 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 0 500711000.0 58786000.0 399840000.0 42085000.0 False True 89182659.83227178 328485428.0358215 33766881.30348924 1.0 3.6832880814904247 0.3786260845661647 26.410259892228506 -6.6907357599850865 1.8636038918069078 2.6811061623097907 0.38989621113811335 0.3738869615688426 1.134677195474338 0.41513065549044426 2.79583446956132 0.486954078795805 1.2669798347244547 2.038281862771452e-07 6.6907357599850865 -2.2912099511716773 HELQANCYEEVKDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HELQANCYEEVKDR 14 1 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 0 145039000.0 17094000.0 64690000.0 63255000.0 False True 23414113.747980386 61831781.898777016 48315471.777617864 1.0 2.640791044423383 2.063519136263929 24.480875095560858 -9.797820726410047 5.911904703214818 0.9999998945155182 2.3521550903473107 0.8797394552895105 0.2356702696518931 3.2830104394925693e-07 6.671771738774643e-08 0.22818677438455043 0.07606225246126758 1.5928661148569845e-10 9.797820726410047 1.3521551958317926 HELQANCYEEVKDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HELQANCYEEVKDR 14 1 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 0 38767500.0 22462000.0 4078500.0 12227000.0 False True 18678148.23532124 4056528.3109811344 14783609.168739496 1.0 0.21718043244297913 0.7914922283774903 24.154848096553366 -10.185186617003943 7.207590627399031 1.0000006642717552 0.5043363304163208 0.4982831066511101 0.23446180888349522 2.50261067434248e-06 2.83012896795965e-07 0.22701697470722612 0.07567222342728694 6.528499617382991e-11 10.185186617003943 -0.4956643338554344 HELQANCYEEVKDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HELQANCYEEVKDR 14 1 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 0 150917000.0 58786000.0 50541000.0 41590000.0 False True 76099635.84530023 47728348.92089035 34021046.74943696 1.0 0.6271823562719185 0.44705925818878983 26.181386214320955 -13.999999999999918 0.09597759225511578 2.8650164838873855 0.03831970719267272 0.9998136822563263 0.003143016034765486 12.112299888662994 0.09142289846682498 4.523200550129425 0.3654809353489735 1.0000000000001882e-14 13.999999999999918 -2.8266967766947126 HELTEISNVDVETQSGK(ub)TVIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HELTEISNVDVETQSGKTVIR 21 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 6068000.0 1365300.0 2067200.0 2635500.0 True False 1789921.5215840074 1758781.8178824903 2362803.74150113 1.0 0.9826027547431466 1.3200599652045892 20.771464903794943 -6.8947459850498385 0.9938539272540959 0.9838766324210307 1.3519371313262651 0.9837671482187464 0.019766229107842898 0.11537796842646637 0.20001594397126232 0.015051076560292727 0.03822499409920883 1.2742481594287566e-07 6.8947459850498385 0.3680604989052344 HELTEISNVDVETQSGK(ub)TVIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HELTEISNVDVETQSGKTVIR 21 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 14358600.0 3050100.0 5277300.0 6031200.0 True False 2953276.2450403264 7384553.410755938 4451447.787878357 1.0 2.5004614529905256 1.5072913667842722 21.493884879642934 -10.531663439709787 5.370043520982445 0.9969331499846171 2.003876409887402 0.5766720580858185 0.4054599898335609 0.014911324937658258 0.0013004589016086426 0.39321473997778195 0.1308616490148993 2.939927091484657e-11 10.531663439709787 1.0069432599027848 HELTEISNVDVETQSGK(ub)TVIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HELTEISNVDVETQSGKTVIR 21 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 51725500.0 9435500.0 13126000.0 29164000.0 True False 14314343.327448707 10783562.7460939 23399722.61696473 1.0 0.7533396747174353 1.6347045813896475 23.770958152225123 -6.832001160109516 1.318962185814948 0.8683761589112495 1.6594038703831522 0.9098221806491342 0.11148749936770518 0.17834849430645774 0.606091793191143 0.06635358760741857 0.15269424719027802 1.4723085695219077e-07 6.832001160109516 0.7910277114719027 HELTEISNVDVETQSGK(ub)TVIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HELTEISNVDVETQSGKTVIR 21 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 8341900.0 1365300.0 4137200.0 2839400.0 True False 1870088.3058451866 3954404.8241091343 2168792.199278605 1.0 2.114555131834772 1.159727159674644 20.834674965317834 -6.608528199523611 2.1592319373696265 1.7453848657725761 1.163105650546911 0.04576880962174101 0.4807045617528213 0.616767639349514 5.44693572344861 0.1839856662468973 0.5337806007831607 2.4630419032918854e-07 6.608528199523611 -0.5822792152256651 HELTEISNVDVETQSGK(ub)TVIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HELTEISNVDVETQSGKTVIR 21 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 9898700.0 3050100.0 4137300.0 2711300.0 True False 2536293.2923405427 4115011.5437102453 3278220.294365211 1.0 1.6224509823597055 1.29252413522728 21.27429015507721 -10.070333188876559 4.469091705585952 0.9999701707098385 1.4574875586395504 0.7193903460898752 0.134692071430389 46740963.992348254 1.5323014893671782 15407.901805782676 0.0461086786332062 8.504852991463753e-11 10.070333188876559 0.45751738792971186 HELTEISNVDVETQSGK(ub)TVIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HELTEISNVDVETQSGKTVIR 21 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 52243500.0 9435500.0 13273000.0 29535000.0 True False 12214440.751511067 12534345.88209528 24159933.054691523 1.0 1.0261907308809564 1.9779811082797762 23.542084474317573 -6.912796153865015 0.8764891615017975 0.9730715403942477 2.108629180288967 0.9919342303684847 0.040861329750226466 0.1025982156391714 0.12895748742000904 0.03392310155630743 0.09555906568476313 1.2223732746334032e-07 6.912796153865015 1.1355576398947194 HEMLPASLIQAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HEMLPASLIQAQR 13 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 10078200.0 1281500.0 3972100.0 4824600.0 False True 1680058.9100636537 3379478.1631245357 4325396.6728311 1.0 2.0115236096075315 2.57455059874491 20.680080390284537 -9.088879569742732 0.18377490569675256 1.1569833562465417e-20 3.2545381780124267 0.9996599941614348 0.012012096943846402 0.5478528918569301 0.0631215167872076 0.6583766403462832 0.3422179135426896 8.149302335909237e-10 9.088879569742732 3.2545381780124267 HEMLPASLIQAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HEMLPASLIQAQR 13 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 8732300.0 1281500.0 4280900.0 3169900.0 False True 1755305.1812353383 4091755.6829567836 2421234.906139771 1.0 2.331079362551139 1.3793811651805008 20.74329045180743 -10.137858185996574 5.388350857499444 0.999980656152746 1.855230263866119 0.5184734963183004 0.38852916211515864 9.02925117667734e-05 1.4447794786318255e-05 0.3762002310167764 0.12539724786550832 7.280174916932619e-11 10.137858185996574 0.8552496077133729 HEMPPHIYAITDTAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HEMPPHIYAITDTAYR 16 0 P35579;P35579-2;Q5BKV1 P35579 MYH9 Myosin-9 0 7831400.0 0.0 2671300.0 5160100.0 False True 0.0 2272752.452645846 4626182.351174344 0.0 HEMPPHIYAITDTAYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HEMPPHIYAITDTAYR 16 0 P35579;P35579-2;Q5BKV1 P35579 MYH9 Myosin-9 0 8693000.0 1449000.0 1849000.0 5395000.0 False True 1403002.2881424981 2587315.342407623 3981887.65346925 1.0 1.8441276712621 2.838119144296665 20.42008593116092 -6.968967149484179 0.28176416650312497 0.7856183468852391 3.926990813383323 0.9999731685629366 0.0038913486018137752 0.07663927830104054 0.010224330012039123 0.018175615222754807 0.09103454767327311 1.0740706531629374e-07 6.968967149484179 3.1413724664980838 HEMPPHIYAITDTAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HEMPPHIYAITDTAYR 16 0 P35579;P35579-2;Q5BKV1 P35579 MYH9 Myosin-9 0 8969500.0 0.0 3550000.0 5419500.0 False True 0.0 3393149.2617198685 4139525.718106081 0.0 HEMPPHIYAITDTAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HEMPPHIYAITDTAYR 16 0 P35579;P35579-2;Q5BKV1 P35579 MYH9 Myosin-9 0 4686390.0 1449000.0 2472400.0 764990.0 False True 1204907.701584029 2459080.6904670233 924945.872085878 1.0 2.040887187652796 0.7676487343137571 20.200491206595196 -6.6893303370536 1.8683133530141014 1.6529458168074034 0.7720200041273888 0.3675736465691535 0.44027667951686367 0.4180727636227627 2.8287236193385867 0.1885371543079518 0.4914659647810648 2.0448886430704837e-07 6.6893303370536 -0.8809258126800146 HEQGLSTALSVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HEQGLSTALSVEK 13 0 Q96I25;H0Y6J6;Q5W012 Q96I25 RBM17 Splicing factor 45 0 7148790.0 954090.0 4027100.0 2167600.0 False True 1250821.229420702 3426272.3775128564 1943317.5450874025 1.0 2.739218280696819 1.5536333245538367 20.25444417988465 -10.503275439388434 5.147334694602971 0.9968191851741043 2.146425802625345 0.5549046352484595 0.4840130315451075 0.017691331654070913 0.0017072351158726384 0.4692709052027386 0.15621453421012177 3.138517543676383e-11 10.503275439388434 1.1496066174512407 HEQGLSTALSVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HEQGLSTALSVEK 13 0 Q96I25;H0Y6J6;Q5W012 Q96I25 RBM17 Splicing factor 45 0 16060800.0 2802700.0 8744200.0 4513900.0 False True 4251900.804815906 7183729.19125357 3621725.686487345 1.0 1.6895335806322045 0.8517897883189574 22.01967650907431 -6.688057045496662 1.8734618307573212 1.433088248615025 0.8547648231035622 0.36124418468049335 0.2917418795986915 0.4208804368459832 2.8625871400784058 0.1246514451217207 0.3253812232644912 2.0508927720389014e-07 6.688057045496662 -0.5783234255114628 HEQGLSTALSVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HEQGLSTALSVEK 13 0 Q96I25;H0Y6J6;Q5W012 Q96I25 RBM17 Splicing factor 45 0 4589090.0 954090.0 1675300.0 1959700.0 False True 1306842.8563127758 1601279.7065237472 1496859.2212884012 1.0 1.2253039443791411 1.1454010817427214 20.317654241407542 -10.114995620242885 4.211545453843068 0.9999666099167631 1.1853525130885567 0.8776731449566371 0.03262020717739005 22740195.739982933 0.4158301432841626 7659.669257796931 0.011166764548234193 7.673692280599365e-11 10.114995620242885 0.1853859031717936 HEQNIDCGGGYVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HEQNIDCGGGYVK 13 0 P27797 P27797 CALR Calreticulin 0 117526700.0 12365500.0 61848000.0 43313200.0 False True 16211290.247672334 52620519.481615804 38831565.55355222 1.0 3.2459180409265214 2.395340837175361 23.950495582941215 -10.342982081605296 5.915442835198756 0.9997635879540787 2.820629439050944 0.859328857105421 0.3472466893389544 0.0010828010538188242 0.0001202652042698281 0.3362602901681038 0.11207338706961781 4.5396034604511344e-11 10.342982081605296 1.8208658510968652 HEQNIDCGGGYVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HEQNIDCGGGYVK 13 0 P27797 P27797 CALR Calreticulin 0 40961800.0 14553300.0 1945600.0 24462900.0 False True 14091313.45757365 2722488.226169962 18055332.618730858 1.0 0.19320329750430099 1.2813094161230705 23.748302756370943 -6.70808697101068 1.801716797690291 0.5030474752075134 1.278647756595993 0.4561740718305404 0.340081623158791 0.3789221190541491 2.3964986755671576 0.15026712008912516 0.38268126998622515 1.9584524381656938e-07 6.70808697101068 0.7756002813884797 HEQNIDCGGGYVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HEQNIDCGGGYVK 13 0 P27797 P27797 CALR Calreticulin 0 329831700.0 33469000.0 267845000.0 28517700.0 False True 50774919.91165074 220045967.06746322 22881164.095248062 1.0 4.333753109809865 0.4506390977092961 25.597612723141523 -6.6794670310215505 1.9037038849141994 3.110325015792462 0.4654678124403563 0.32168558485904375 1.4130916911246305 0.4397294174944863 3.0806223891539224 0.5957066559096432 1.5722542951017713 2.0918617024101077e-07 6.6794670310215505 -2.644857203352106 HEQNIDCGGGYVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HEQNIDCGGGYVK 13 0 P27797 P27797 CALR Calreticulin 0 120916500.0 12365500.0 54368000.0 54183000.0 False True 16937359.51507262 51965841.989066474 41386091.33391306 1.0 3.068119439917531 2.4434795339310957 24.013705644464107 -10.022789341689336 5.228485102378281 0.9999863496574946 2.7557994869297593 0.9133063372787579 0.25500817379349333 4.057716720716864e-05 7.583830026405582e-06 0.2469125125601111 0.08230353418467384 9.488786135052468e-11 10.022789341689336 1.7558131372722647 HEQNIDCGGGYVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HEQNIDCGGGYVK 13 0 P27797 P27797 CALR Calreticulin 0 99201400.0 33469000.0 27187700.0 38544700.0 False True 43326280.27262188 25674680.595090926 31529960.102020245 1.0 0.5925890806581635 0.7277329118406735 25.368739045233973 -10.348383799373233 4.947322620114033 1.0002030101036434 0.6601609962493219 0.8939696811459205 0.05517223804733099 0.0001236138516750048 1.6281190297297657e-05 0.05345191167087032 0.01780676326081092 4.483489950275814e-11 10.348383799373233 -0.34004201385432153 HESGASIK(ub)IDEPLEGSEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HESGASIKIDEPLEGSEDR 19 1 P61978;P61978-2;S4R359;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 47704100.0 22000700.0 18192100.0 7511300.0 True False 28843130.755081873 15477909.592250386 6734102.729477306 1.0 0.5366237709657552 0.23347336274481312 24.78172443349519 -8.332465137324233 0.2554748499809132 1.2073602287102407 1.964465927200141e-26 0.9993838862628922 0.007823872055315137 0.107100088941319 0.06081789891522309 0.10695736359321137 0.1055443688084177 4.6508770924798805e-09 8.332465137324233 -1.2073602287102407 down HESGASIK(ub)IDEPLEGSEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HESGASIKIDEPLEGSEDR 19 1 P61978;P61978-2;S4R359;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 56570200.0 24129000.0 23469500.0 8971700.0 True False 23363038.10254683 32840993.741825618 6621742.6247692555 1.0 1.4056816411323485 0.2834281481588395 24.477724557028864 -6.808871253233702 1.4190014078022573 1.221378038458348 0.2642340488022014 0.8569786567189083 0.175469107682827 0.2083062315960188 0.8268448535799159 0.09723427957955522 0.22506843141050645 1.5528472839054412e-07 6.808871253233702 -0.9571439896561464 down HESGASIK(ub)IDEPLEGSEDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HESGASIKIDEPLEGSEDR 19 1 P61978;P61978-2;S4R359;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 56206200.0 17768600.0 18069700.0 20367900.0 True False 26956265.258661967 14845020.855789503 16342175.637432296 1.0 0.550707626347433 0.6062477676569457 24.68411729181271 -10.134790797587625 5.1004706261989865 1.0000162872000595 0.5784776970022156 0.9871466652483317 0.02267416774395492 31675094.930684958 0.8456434325687877 6058.855841324337 0.007761970715923872 7.331776244107893e-11 10.134790797587625 -0.4215385901978439 HESGASIK(ub)IDEPLEGSEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HESGASIKIDEPLEGSEDR 19 1 P61978;P61978-2;S4R359;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 45832900.0 22000700.0 19294400.0 4537800.0 True False 30134953.33656208 18441909.60995152 3466065.0989245847 1.0 0.6119773740474439 0.11501810074878344 24.84493449501808 -7.581251544594999 0.4884579032104553 1.0179225124590179 3.396335858960155e-21 0.9968116142403975 0.02045211270357903 0.11795260937286947 0.07610626242411588 0.024500216530782715 0.0719095731114259 2.6226990286614212e-08 7.581251544594999 -1.0179225124590179 down HESGASIK(ub)IDEPLEGSEDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HESGASIKIDEPLEGSEDR 19 1 P61978;P61978-2;S4R359;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 52926600.0 24129000.0 25648400.0 3149200.0 True False 20064332.595942754 25510226.97839118 3807683.159744372 1.0 1.2714216561357068 0.18977372616492266 24.25812983246314 -6.840226864174037 1.2812647926302683 1.1443883720847374 0.154020010869391 0.9248578435194867 0.12595303540372474 0.16853162761812168 0.5373208409297451 0.07707847977046546 0.17759233568683047 1.444684907674389e-07 6.840226864174037 -0.9903683612153464 down HESGASIK(ub)IDEPLEGSEDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HESGASIKIDEPLEGSEDR 19 1 P61978;P61978-2;S4R359;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 59006700.0 17768600.0 19712100.0 21526000.0 True False 23001802.97146939 18615104.306671496 17608488.875411894 1.0 0.8092889209494144 0.7655264631756402 24.45524361390516 -13.999999999656909 0.20681341708748402 2.088761034609449 0.7389398452203293 0.9994884685968164 0.0023023421769558083 12.673922809902004 0.14416286665218248 5.598628658856615 0.02651370343308804 1.0000000007899959e-14 13.999999999656909 -1.3498211893891197 HESVSK(ub)ISTISSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HESVSKISTISSVR 14 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 11001300.0 4946200.0 3552200.0 2502900.0 True False 6484516.099068936 3022225.6063671503 2243923.917512113 1.0 0.4660680242279126 0.34604338754503233 22.628567488053854 -13.999999999999998 0.20972589847130083 4.084444865994827 0.27516081491753225 0.999489859542596 0.006419999812270176 12.740300278425016 0.145155700605333 16.190656615733666 0.07123353324017787 1.0000000000000041e-14 13.999999999999998 -3.809284051077295 HESVSK(ub)ISTISSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HESVSKISTISSVR 14 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 15036300.0 3954300.0 4476400.0 6605600.0 True False 3828772.9109743834 6263849.864117613 4875395.196247735 1.0 1.635994092562551 1.2733571067308342 21.868450664109616 -10.09615103833553 4.407483436138914 0.9999582052130005 1.4546755995694045 0.6770058871291929 0.1480459296648614 77870877.8826564 3.665007070410098 37306.06358535271 0.05417926256225978 8.013993053730702e-11 10.09615103833553 0.454717394356404 HESVSK(ub)ISTISSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HESVSKISTISSVR 14 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 10169800.0 4946200.0 2794600.0 2429000.0 True False 6774943.806029051 2671125.331493616 1855320.2268252946 1.0 0.39426531170879536 0.2738502753593672 22.691777549576745 -13.999999999999963 0.2271165728341543 4.773502278970879 0.21367375284820533 0.9995059944948623 0.007062469779673191 13.203133855259587 0.15091754778853572 22.431093343011863 0.06364703903458434 1.0000000000000858e-14 13.999999999999963 -4.559828526122674 HESVSK(ub)ISTISSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HESVSKISTISSVR 14 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 13130000.0 3954300.0 7395800.0 1779900.0 True False 3288175.655192358 7355957.357448631 2152068.860672237 1.0 2.237093795713997 0.654487194829116 21.648855939543893 -6.698156823736494 1.8373282525927346 1.7695698050836148 0.6593427870228301 0.4088594759315274 0.5223715438875206 0.39938475641681725 2.6198271137256635 0.22692253736750315 0.5849411966595605 2.0037483431893718e-07 6.698156823736494 -1.1102270180607847 HESVSK(ub)ISTISSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HESVSKISTISSVR 14 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 32599200.0 8259900.0 6176300.0 18163000.0 True False 10692603.37697063 5832583.475595963 14857520.368117893 1.0 0.5454783339441904 1.3895138390822128 23.350109819587757 -6.760434930045096 1.6107775082622322 0.7361310232843165 1.3926695337606145 0.6927574784951617 0.191185393013702 0.2821899816303886 1.4431281674641538 0.09364282585960046 0.22494690723160632 1.7360613559108827e-07 6.760434930045096 0.6565385104762981 HETLK(ub)ELEALGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HETLKELEALGK 12 1 Q6I9Y2;A0A5S6STF9 Q6I9Y2 THOC7 THO complex subunit 7 homolog 1 9982500.0 1467600.0 2209700.0 6305200.0 True False 1421011.8413236258 3092044.733433271 4653678.968054559 1.0 2.17594578983461 3.274905129375847 20.438487145965173 -6.971941273712708 0.20662717245070664 0.3992852664471738 5.082128964978539 0.9999938261359985 0.0023080633017960404 0.07567769782644933 0.006727083524878061 0.03380745938246996 0.1147844171762514 1.0667403585347036e-07 6.971941273712708 4.682843698531365 HETSKMRVLRFIAQNQNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HETSKMRVLRFIAQNQNR 18 3 Q96JG8-2;Q96JG8;Q96JG8-4 Q96JG8-2 MAGED4 Melanoma-associated antigen D4 0 28365800.0 3523700.0 2220100.0 22622000.0 False True 4619604.823559343 1888869.7338820198 20281292.445546802 1.0 0.4088812368211771 4.390265665607376 22.139338013286835 -6.869125392371363 1.138655069331146 0.6673606885306969 4.61964889514168 0.9638054583837775 0.33373285845750916 0.13769925800076052 0.3342121392345714 0.22757487242570965 0.5380128426143888 1.3516822402243137e-07 6.869125392371363 3.952288206610983 up HETSKMRVLRFIAQNQNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HETSKMRVLRFIAQNQNR 18 3 Q96JG8-2;Q96JG8;Q96JG8-4 Q96JG8-2 MAGED4 Melanoma-associated antigen D4 0 15422400.0 2732900.0 2669500.0 10020000.0 False True 2646145.5854138294 3735445.271258595 7395461.406443363 1.0 1.4116552361477157 2.7948051865357932 21.33546100719798 -6.948879168948743 0.5710148749069598 0.9828481479469168 3.29097747268836 0.9991103744468739 0.02289705296262601 0.08393893793783837 0.037849074087547674 0.024230039720045907 0.1152724460255181 1.1249179093418739e-07 6.948879168948743 2.308129324741443 up HETSKMRVLRFIAQNQNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HETSKMRVLRFIAQNQNR 18 3 Q96JG8-2;Q96JG8;Q96JG8-4 Q96JG8-2 MAGED4 Melanoma-associated antigen D4 0 10182300.0 3523700.0 2625000.0 4033600.0 False True 4826507.114411988 2509018.8202858176 3080946.7545996313 1.0 0.5198415253121388 0.638338798962898 22.202548074809727 -10.031356981301238 7.287059960859098 1.0000000367814903 0.5790901621375424 0.943892323147482 0.04837630939255129 2.8979699909588748e-08 3.831300441711701e-09 0.04684016434490072 0.015613386719027341 9.303428380471671e-11 10.031356981301238 -0.4209098746439479 HETWSGHVISS ddPTM_RPMI8226_Bortezomib_1h_R1 1 HETWSGHVISS 11 0 Q9Y2V2 Q9Y2V2 CARHSP1 Calcium-regulated heat stable protein 1 0 23362200.0 6084100.0 7311300.0 9966800.0 False True 7976314.018508204 6220482.539224185 8935531.144296525 1.0 0.7798693136692217 1.1202581948958577 22.92729077745882 -6.7321114146736765 1.7154264664702437 0.8678390412051005 1.1201387958341595 0.5690597334639771 0.0925234421057143 0.3323009569065441 1.9166346330178443 0.0427246760953003 0.10577015334524907 1.853056176126068e-07 6.7321114146736765 0.25229975462905907 HETWSGHVISS ddPTM_RPMI8226_Bortezomib_2h_R1 1 HETWSGHVISS 11 0 Q9Y2V2 Q9Y2V2 CARHSP1 Calcium-regulated heat stable protein 1 0 18232000.0 4901400.0 3416500.0 9914100.0 False True 4745807.739890718 4780726.266812131 7317299.793375261 1.0 1.0073577626476324 1.5418449702186539 22.178222225202738 -6.90989966545845 0.8964195610156346 0.9833985157246679 1.6107699867689262 0.9908835561429584 0.02422441121303038 0.10448452058182352 0.13912828055566898 0.019822988865750804 0.05468233340875085 1.2305530311893025e-07 6.90989966545845 0.6273714710442584 HETWSGHVISS ddPTM_RPMI8226_Bortezomib_8h_R1 1 HETWSGHVISS 11 0 Q9Y2V2 Q9Y2V2 CARHSP1 Calcium-regulated heat stable protein 1 0 55407000.0 16657000.0 38750000.0 0.0 False True 25269886.78981644 31834759.744868133 0.0 1.0 1.259790358763985 0.0 24.590915865172647 -6.895098489071967 1.30844420523478 1.1352905424466893 2.711174396678178e-19 0.9431920117671069 0.1294434114043228 0.137846640714862 0.4738988957211907 0.0806594984154925 0.16162118304709994 1.2732143094092367e-07 6.895098489071967 -1.1352905424466893 down HETWSGHVISS ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HETWSGHVISS 11 0 Q9Y2V2 Q9Y2V2 CARHSP1 Calcium-regulated heat stable protein 1 0 24908400.0 6084100.0 8219300.0 10605000.0 False True 8333556.186620297 7856144.148409606 8100317.416830899 1.0 0.9427120874306714 0.9720120960888381 22.99050083898171 -10.12788514818946 4.136340754666542 1.000009779267809 0.9573620917666498 0.7384626946370919 0.011961678480612777 16698700.380648691 0.20644285453673525 1674.7160836770945 0.004094800700634654 7.44928948839128e-11 10.12788514818946 -0.042647687501159326 HETWSGHVISS ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HETWSGHVISS 11 0 Q9Y2V2 Q9Y2V2 CARHSP1 Calcium-regulated heat stable protein 1 0 13123700.0 4901400.0 5267400.0 2954900.0 False True 4075731.2688364172 5239023.470702966 3572755.928086066 1.0 1.285419259793018 0.8765926142883445 21.958627500637014 -6.719022442745533 1.763091503567536 1.1738287764677273 0.8772756625458629 0.5077965024502451 0.12012003647183549 0.35721337700698114 2.1695978165815437 0.05411071138598298 0.13598128737618262 1.9097545669065263e-07 6.719022442745533 -0.29655311392186445 HETWSGHVISS ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HETWSGHVISS 11 0 Q9Y2V2 Q9Y2V2 CARHSP1 Calcium-regulated heat stable protein 1 0 46267000.0 16657000.0 16467000.0 13143000.0 False True 21562814.858557552 15550596.974343626 10751108.858568165 1.0 0.7211765753380811 0.4985948694124883 24.362042187265097 -7.13069644260475 0.1561557574336862 1.2487264077978582 9.527123037083843e-12 0.99999742387372 0.00032918400600400144 0.0805825448532499 0.005862513935117741 0.013806213589414156 0.03132325499080492 7.401224152520233e-08 7.13069644260475 -1.248726407788331 down HEVININLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HEVININLK 9 0 Q5TA02;P78417-3;P78417;Q5TA01;P78417-2 Q5TA02 GSTO1 Glutathione S-transferase omega-1 0 27659700.0 6172500.0 7924200.0 13563000.0 False True 8092207.274575027 6741940.248289679 12159630.865482764 1.0 0.8331398368245259 1.502634627722304 22.948101843023103 -6.84071351080503 1.2789951375595707 0.9112374453777723 1.5249783812786974 0.925682315405937 0.07757134956348379 0.16797116266376264 0.5334259104800279 0.047550570619687586 0.10957413814531654 1.443066979472974e-07 6.84071351080503 0.6137409359009252 HEVININLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HEVININLK 9 0 Q5TA02;P78417-3;P78417;Q5TA01;P78417-2 Q5TA02 GSTO1 Glutathione S-transferase omega-1 0 23266000.0 7796800.0 2983200.0 12486000.0 False True 7549294.851752552 4174407.3171824827 9215542.02802912 1.0 0.552953275657713 1.2207156044368503 22.847910463908946 -6.726287623247884 1.7364409084919226 0.7298569634466281 1.2200761977236323 0.5420052370446857 0.18799079471398625 0.343298910708859 2.0260657668024105 0.08584847738407113 0.2139548213123292 1.8780726005475782e-07 6.726287623247884 0.4902192342770042 HEVININLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HEVININLK 9 0 Q5TA02;P78417-3;P78417;Q5TA01;P78417-2 Q5TA02 GSTO1 Glutathione S-transferase omega-1 0 54671900.0 7722900.0 32554000.0 14395000.0 False True 11716203.919617794 26744484.354437068 11549821.940447368 1.0 2.282691948512068 0.9857989857199537 23.482001872754932 -6.648711100256297 2.0129609158011483 1.8332058812333698 0.991238908773324 0.18879165787227925 0.5476454977467231 0.5117826522416109 3.97336405466058 0.22074451631475 0.6066145313664029 2.2453750870695086e-07 6.648711100256297 -0.8419669724600458 HEVININLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HEVININLK 9 0 Q5TA02;P78417-3;P78417;Q5TA01;P78417-2 Q5TA02 GSTO1 Glutathione S-transferase omega-1 0 27512300.0 6172500.0 6456800.0 14883000.0 False True 8454640.055540476 6171517.226217702 11367941.92500652 1.0 0.7299562353542652 1.3445802364533432 23.011311904545995 -6.787269355602332 1.5070956244889622 0.8485325145803143 1.3506453691278133 0.79238093084838 0.1146118238495945 0.23945492568288432 1.0744704880747147 0.059866730144887643 0.14045434050937575 1.632039419920228e-07 6.787269355602332 0.502112854547499 HEVININLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HEVININLK 9 0 Q5TA02;P78417-3;P78417;Q5TA01;P78417-2 Q5TA02 GSTO1 Glutathione S-transferase omega-1 0 15639000.0 7796800.0 3501900.0 4340300.0 False True 6483384.656804951 3483034.5696272743 5247836.662720216 1.0 0.5372247296744126 0.8094285532190497 22.628315739343222 -10.25663185155439 5.71757724762219 1.0000183589950782 0.673326641446727 0.6575739105842124 0.1111267456198418 2.600791513307421e-05 3.3814297160240622e-06 0.10760405041202019 0.03586600292532052 5.538193791682132e-11 10.25663185155439 -0.32669171754835113 HEVININLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HEVININLK 9 0 Q5TA02;P78417-3;P78417;Q5TA01;P78417-2 Q5TA02 GSTO1 Glutathione S-transferase omega-1 0 42503900.0 7722900.0 22294000.0 12487000.0 False True 9997446.291118106 21053319.30199895 10214494.127439748 1.0 2.1058697080176425 1.021710327817862 23.25312819484738 -6.641591947741146 2.038822993509066 1.722314063485463 1.0262446175004438 0.16066032709280065 0.4729840719641871 0.5293944128412618 4.207785724004802 0.18879680593788914 0.5237193332377484 2.2824856313728416e-07 6.641591947741146 -0.6960694459850192 HEVTICNYEASANPADHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HEVTICNYEASANPADHR 18 0 Q9GZP4-2;Q9GZP4;X6R8S9 Q9GZP4-2 PITHD1 PITH domain-containing protein 1 0 6453100.0 1776700.0 1797100.0 2879300.0 False True 2329270.905587273 1528979.6850409345 2581377.656195864 1.0 0.6564198614138602 1.1082341903656878 21.1514470111136 -6.703416990912862 1.818909942207538 0.78736845591657 1.1069705850606244 0.43374970354005327 0.1449405703175793 0.3884329906966593 2.500777834811472 0.06351848903886029 0.16265363016868478 1.9796253617361353e-07 6.703416990912862 0.3196021291440544 HEVTICNYEASANPADHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HEVTICNYEASANPADHR 18 0 Q9GZP4-2;Q9GZP4;X6R8S9 Q9GZP4-2 PITHD1 PITH domain-containing protein 1 0 6173300.0 1776700.0 2325500.0 2071100.0 False True 2433594.0035121515 2222751.720599873 1581948.8356434193 1.0 0.9133617675717511 0.6500463238158699 21.21465707263649 -6.951157895677451 0.5459823125321793 1.0037313427307024 0.5473914752992304 0.9992890541844007 0.003967891191729626 0.08302406705233786 0.034063498115304604 0.004329236551845265 0.02182820870466376 1.1190309653894681e-07 6.951157895677451 -0.45633986743147203 HEVTILGGLNEFVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HEVTILGGLNEFVVK 15 0 H7C4M9;C9JZG9;C9JZY6;P62256-2;P62256 H7C4M9 UBE2H Ubiquitin-conjugating enzyme E2 H 0 3899400.0 1602100.0 1091500.0 1205800.0 False True 1551242.212445202 1527341.6420973039 889964.8067753884 1.0 0.9845926250870752 0.5737110553306495 20.564992537072303 -6.91482669395043 0.8622095067964121 1.010863203195263 0.5147398125630094 0.9926192844180658 0.016960842444574305 0.10131233670683082 0.12209118327349362 0.014226374127938682 0.040718000152735655 1.2166714188597178e-07 6.91482669395043 -0.4961233906322535 HEVWGSNQNYICNTDPETDGLSPSVASPSPK(ub)EVNFVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HEVWGSNQNYICNTDPETDGLSPSVASPSPKEVNFVSR 38 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 10971500.0 5964400.0 2348500.0 2658600.0 True False 4959662.867721036 2335848.16435925 3214500.9680224773 1.0 0.4709691417861577 0.6481289260492699 22.24181062630782 -10.136912017511914 5.551336981829352 1.0000071220551305 0.5595490339176444 0.891791862264033 0.072325179064609 6.3752570386912526e-06 9.912186996808456e-07 0.07002968512875335 0.023342851169022523 7.296053039539795e-11 10.136912017511914 -0.4404580881374861 HFAGDVLGYVTPWNSHGYDVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HFAGDVLGYVTPWNSHGYDVTK 22 0 Q9BWS9-3;Q9BWS9;E9PPA0;Q9BWS9-2;E9PI70;E9PIP0;E9PRL3;E9PPH0 Q9BWS9-3 CHID1 Chitinase domain-containing protein 1 0 10334800.0 3843400.0 4373500.0 2117900.0 False True 3195957.391489346 4349939.087428219 2560743.0979368123 1.0 1.3610754320479554 0.8012444423558106 21.607816743704962 -6.732558937937469 1.7138876926214504 1.2166700683119422 0.8014174092035008 0.5711116658444788 0.15175910468618523 0.3314527930716242 1.9085286207205254 0.07013686788754339 0.17353873842672865 1.8511476586197823e-07 6.732558937937469 -0.41525265910844145 HFANQPLIGSETGTLMVLK(ub)HPYPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFANQPLIGSETGTLMVLKHPYPR 24 1 Q9UN19;J3KNB3;Q9UN19-2 Q9UN19 DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 1 59034800.0 2091300.0 4293500.0 52650000.0 True False 2707229.0756859863 4054562.9507101737 43068240.2346202 1.0 1.4976800401284054 15.908605821879743 21.36838553754698 -6.91423061680839 0.8664352600443381 0.6112694401270751 17.949831890204344 0.9924224254968392 0.6018295401621843 0.10168623858858652 0.12408636911853838 0.5032747042727534 1.4335569615604253 1.2183424692090245e-07 6.91423061680839 17.33856245007727 up HFCPNVPIILVGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HFCPNVPIILVGNK 14 0 P61586;Q5JR07;C9JNR4;E9PQH6;C9JX21;Q5JR08;Q5JR05;P08134 P61586 RHOA;RHOC Transforming protein RhoA;Rho-related GTP-binding protein RhoC 0 36565700.0 13042100.0 14117700.0 9405900.0 False True 17098319.39987605 12011394.190363578 8432667.695763798 1.0 0.702489754077857 0.49318693250197027 24.027351193263193 -7.836292666369056 0.13563485403560155 1.3721267238520674 8.920229301157945e-11 0.9999759430824675 0.001019921522833836 0.12651516270392002 0.01912335209141922 0.07684556174805007 0.1014447818298285 1.4578315122422381e-08 7.836292666369056 -1.3721267237628652 down HFCPNVPIILVGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFCPNVPIILVGNK 14 0 P61586;Q5JR07;C9JNR4;E9PQH6;C9JX21;Q5JR08;Q5JR05;P08134 P61586 RHOA;RHOC Transforming protein RhoA;Rho-related GTP-binding protein RhoC 0 29352900.0 13042100.0 8906900.0 7403900.0 False True 17864116.819500107 8513363.706820484 5655251.308106955 1.0 0.47656225005915037 0.3165704392356972 24.090561254786085 -13.999999999999861 0.16603118233334546 3.613416747317968 0.16930672932364904 0.9995218176155909 0.006382295031525733 12.0553547990988 0.12894442430305592 10.144492053323471 0.13530777631285437 1.000000000000319e-14 13.999999999999861 -3.4441100179943187 HFCPNVPIILVGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HFCPNVPIILVGNK 14 0 P61586;Q5JR07;C9JNR4;E9PQH6;C9JX21;Q5JR08;Q5JR05;P08134 P61586 RHOA;RHOC Transforming protein RhoA;Rho-related GTP-binding protein RhoC 0 8549680.0 5382600.0 684180.0 2482900.0 False True 4475870.389610901 680494.1865409033 3002062.910367492 1.0 0.15203616890257193 0.6707215913435933 22.093736829281703 -9.946726919409764 5.9808282139026625 1.000000295386322 0.41137888023676467 0.6319641582050641 0.21175243700062024 8.339197266259925e-07 1.4660715825450836e-07 0.20502851937733718 0.06834280516843975 1.1305065439058216e-10 9.946726919409764 -0.5886214151495575 HFCPNVPIILVGNKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HFCPNVPIILVGNKK 15 1 P61586;Q5JR07;C9JNR4;E9PQH6;C9JX21;Q5JR08;Q5JR05;P08134 P61586 RHOA;RHOC Transforming protein RhoA;Rho-related GTP-binding protein RhoC 0 56120200.0 15397200.0 13683800.0 27039200.0 False True 20185878.306696914 11642230.379034642 24241442.96232115 1.0 0.5767512417417174 1.2009109831143068 24.266843025424244 -6.724070924959086 1.744502549849836 0.7436272478203997 1.2001789509525413 0.5317100753008688 0.17802187196610145 0.3474764343379132 2.0687021330417097 0.08095703329435072 0.20227845138826114 1.8876830449818193e-07 6.724070924959086 0.45655170313214166 HFCPNVPIILVGNKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFCPNVPIILVGNKK 15 1 P61586;Q5JR07;C9JNR4;E9PQH6;C9JX21;Q5JR08;Q5JR05;P08134 P61586 RHOA;RHOC Transforming protein RhoA;Rho-related GTP-binding protein RhoC 0 19441800.0 5379200.0 8213800.0 5848800.0 False True 6963480.4398842985 7756694.809489512 4784378.413755873 1.0 1.1139106193308117 0.68706711465041 22.731377133777137 -6.835691271432161 1.3021239464103649 1.0606729414529432 0.6741729424364983 0.9168087383311035 0.05205039430178066 0.17389374201852772 0.5745619781794505 0.03136369033390924 0.07219883049270585 1.4598516617963476e-07 6.835691271432161 -0.38649999901644494 HFDETVNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFDETVNR 8 0 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 3100970.0 828130.0 1620100.0 652740.0 False True 1134312.0403717675 1548518.6250457366 498576.25560228195 1.0 1.3651610579203708 0.4395406535920002 20.11338613832641 -6.799680032336735 1.4571958974025672 1.2015592622562217 0.4268612252380122 0.8312257964174258 0.15638998565003087 0.22121882306322177 0.9274132788681329 0.0844309633954528 0.19639568278550606 1.5860612971628187e-07 6.799680032336735 -0.7746980370182095 down HFELGGDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HFELGGDK 8 0 H0Y5B4;H7BZ11;J3KQN4;P83881;R4GN19;Q969Q0 H0Y5B4;Q969Q0 RPL36A;RPL36A-HNRNPH2;RPL36AL 60S ribosomal protein L36a;60S ribosomal protein L36a-like 0 8921000.0 1703200.0 4161500.0 3056300.0 False True 2232911.693812264 3540620.4213999454 2740063.3940997524 1.0 1.5856517887436121 1.2271257308082906 21.090494766557892 -10.155586088657365 4.477620069400592 0.9999458357110252 1.4063887596970477 0.6314168320596283 0.14636765047206338 9.833978841225914e-05 1.8545528467578843e-05 0.14174326562448 0.047239956023739135 6.988981829178226e-11 10.155586088657365 0.40644292398602244 HFELGGDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HFELGGDK 8 0 H0Y5B4;H7BZ11;J3KQN4;P83881;R4GN19;Q969Q0 H0Y5B4;Q969Q0 RPL36A;RPL36A-HNRNPH2;RPL36AL 60S ribosomal protein L36a;60S ribosomal protein L36a-like 0 15674200.0 3368200.0 9202700.0 3103300.0 False True 5109805.648403661 7560406.2839767095 2489931.3947752924 1.0 1.4795878364451363 0.48728495095565216 22.284836988585607 -6.775286218936911 1.5541062297008528 1.2732266375281598 0.4805433690740562 0.7503532138134775 0.2024474328943015 0.2579953928786309 1.2303800328991508 0.10263344769315932 0.24315646487512083 1.6776979778223983e-07 6.775286218936911 -0.7926832684541036 down HFELGGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFELGGDK 8 0 H0Y5B4;H7BZ11;J3KQN4;P83881;R4GN19;Q969Q0 H0Y5B4;Q969Q0 RPL36A;RPL36A-HNRNPH2;RPL36AL 60S ribosomal protein L36a;60S ribosomal protein L36a-like 0 8565400.0 1703200.0 3195100.0 3667100.0 False True 2332919.067249341 3053929.917217229 2801006.5062951967 1.0 1.3090595212194847 1.2006445254004292 21.153704828080784 -10.08159517792126 4.270878161594162 0.9999708252205228 1.2548520232718428 0.8804938770339568 0.04426023684408069 6425463.539536985 7583794.932993116 1436.766515721897 0.015151455646803202 8.287142792749236e-11 10.08159517792126 0.2548811980513199 HFELGGDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFELGGDK 8 0 H0Y5B4;H7BZ11;J3KQN4;P83881;R4GN19;Q969Q0 H0Y5B4;Q969Q0 RPL36A;RPL36A-HNRNPH2;RPL36AL 60S ribosomal protein L36a;60S ribosomal protein L36a-like 0 9130700.0 3368200.0 2451400.0 3311100.0 False True 4360201.297147961 2314977.435046211 2708513.774755004 1.0 0.5309336145926231 0.6211900759092618 22.055963310678056 -10.10734352633084 5.407126143125938 1.000006318240557 0.5760618452507716 0.9671228244233702 0.03684704603653307 2.8065691275177996e-06 4.632977058766842e-07 0.03567753032072503 0.011892332971268287 7.810097825420919e-11 10.10734352633084 -0.4239444729897853 HFFINICHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFFINICHR 9 0 P11717 P11717 IGF2R Cation-independent mannose-6-phosphate receptor 0 48146000.0 11967000.0 11739000.0 24440000.0 False True 16391523.296015069 11220332.164318193 18667775.35759988 1.0 0.6845204049489384 1.1388676342325177 23.966446597324172 -6.719992132428747 1.7597507539637116 0.808060757046425 1.1381396641585897 0.512318769231334 0.13275495644054933 0.35532144267668686 2.1504898454967645 0.059905612867440235 0.15036376303857452 1.9054952371302742e-07 6.719992132428747 0.3300789071121647 HFGTILNYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HFGTILNYLR 10 0 Q9H3F6;F5GWA4;Q9H3F6-2;F5H6V0;F5H497;I3L1U2;A0A3B3IS45;I3L108;Q8WZ19;J3QSD4;J3QS43;Q13829 Q9H3F6;J3QSD4 KCTD10;KCTD13;TNFAIP1 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3;BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1;BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 2 0 4525400.0 1415600.0 1162500.0 1947300.0 False True 1177134.121713149 1156237.3817618166 2354471.4267020845 1.0 0.9822477833529113 2.000172608432666 20.166847278576135 -6.902933956691042 0.9425526016509967 0.9610175041279595 2.113614943631273 0.98796976248142 0.05217871477212778 0.10927719450934785 0.16549828520927665 0.04127989299142615 0.10907144061043879 1.250449171989002e-07 6.902933956691042 1.1525974395033134 up HFIDVGAGVIDEDYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HFIDVGAGVIDEDYR 15 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 38331300.0 8178800.0 17880800.0 12271700.0 False True 10722486.003611874 15213054.338812498 11001942.20245853 1.0 1.418799179004568 1.0260626312547783 23.35413609699238 -10.668564789702152 7.940606703734063 0.9994807237305832 1.2224309051296731 0.29956651041517546 0.16033402422153095 0.001477248208348865 6.165917209996591e-05 0.1555911699890291 0.051747583803367164 2.1450390868575548e-11 10.668564789702152 0.22295018139908995 HFIDVGAGVIDEDYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HFIDVGAGVIDEDYR 15 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 55947700.0 12452000.0 13793500.0 29702200.0 False True 12056718.075880188 19301316.48215224 21922302.773099978 1.0 1.6008764873390444 1.8182645256470062 23.52333391307317 -11.01539412254632 0.19673757928782226 8.507569708513893e-14 1.9952476382144753 0.9993957406596027 0.00850693096578195 3.1177263928018704 0.10988331178821856 1.5483339182134157 0.13876812667290647 9.651745848198496e-12 11.01539412254632 1.9952476382143902 HFIDVGAGVIDEDYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HFIDVGAGVIDEDYR 15 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 352560000.0 49171000.0 222270000.0 81119000.0 False True 74596001.88161516 182604181.89656353 65085794.09427919 1.0 2.447908430620166 0.8725104892025072 26.152594972706268 -6.6650547946335585 1.954624457372112 1.928113206652652 0.8789724151336051 0.25730193776025834 0.615754192695678 0.47266922513944615 3.476490020698486 0.25402921090150854 0.6831785429054565 2.162445672244029e-07 6.6650547946335585 -1.049140791519047 HFIDVGAGVIDEDYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFIDVGAGVIDEDYR 15 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 45197200.0 8178800.0 18144200.0 18874200.0 False True 11202723.383759337 17342529.249154266 14416502.68635074 1.0 1.5480636855048877 1.286874824317312 23.417346158515272 -10.033597859442494 4.374666449682179 0.9999762229763898 1.4174692549109007 0.7730504142974446 0.10662990628580411 24578549.44350024 0.12773483743206826 6118.614374516808 0.03650225307860493 9.25554806641351e-11 10.033597859442494 0.4174930319345109 HFIDVGAGVIDEDYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HFIDVGAGVIDEDYR 15 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 36430900.0 12452000.0 12352200.0 11626700.0 False True 10354389.717132047 12285656.246880258 14057789.214213107 1.0 1.186516693161819 1.357664681188649 23.303739188507446 -6.9721538997163615 0.2001626924402838 0.8983422108695818 1.6505653806418004 0.9999946668339255 0.000337258545646917 0.07560977906505253 0.006464261079297019 0.005549182143589022 0.018161975122655726 1.0662182215186068e-07 6.9721538997163615 0.7522231697722186 HFIDVGAGVIDEDYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFIDVGAGVIDEDYR 15 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 261900000.0 49171000.0 130510000.0 82219000.0 False True 63652828.80531507 123247003.77248973 67255985.63818128 1.0 1.9362376517380873 1.056606389700081 25.923721294798717 -6.631434253344101 2.074912799869945 1.6161477321210809 1.0601392244015864 0.12280482658027148 0.40144724915399 0.5552716629301718 4.557432614651857 0.15812769670717436 0.4447689090227367 2.3364997917705443e-07 6.631434253344101 -0.5560085077194945 HFILDECDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HFILDECDK 9 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;A0A140T996;A0A140T9X9;F6UJC5;A0A140TA18;A0A140T9K1;A0A140T973;A0A140T9L4 Q13838-2 DDX39B Spliceosome RNA helicase DDX39B 0 22436100.0 2474300.0 9619800.0 10342000.0 False True 3243831.261155285 8184563.337686698 9271909.047469046 1.0 2.523116240877394 2.8583203936960864 21.62926734417344 -10.181256941829291 0.34592093983465544 5.352955500353093e-16 2.9283906479111583 0.9989498760092147 0.026205616516300476 1.5860998651406424 0.15877571336985055 1.617452918152384 0.10056177374202997 6.587840232533787e-11 10.181256941829291 2.928390647911158 HFILDECDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFILDECDK 9 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;A0A140T996;A0A140T9X9;F6UJC5;A0A140TA18;A0A140T9K1;A0A140T973;A0A140T9L4 Q13838-2 DDX39B Spliceosome RNA helicase DDX39B 0 20608100.0 2474300.0 8774100.0 9359700.0 False True 3389115.5754433065 8386431.249931345 7149131.629072332 1.0 2.474519107786513 2.109438722265234 21.69247740569633 -10.123228324574603 5.992612097956463 0.9999928038057716 2.2919789150259016 0.9434974383030406 0.14904344327104982 1.432972618416611e-05 2.096374394982617e-06 0.14431149621232103 0.04810356447083424 7.529596011142952e-11 10.123228324574603 1.29198611122013 HFILDECDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFILDECDK 9 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;A0A140T996;A0A140T9X9;F6UJC5;A0A140TA18;A0A140T9K1;A0A140T973;A0A140T9L4 Q13838-2 DDX39B Spliceosome RNA helicase DDX39B 0 19052100.0 7598700.0 4838300.0 6615100.0 False True 9836666.942770083 4569044.351792483 5411219.676657858 1.0 0.4644911104925348 0.5501070340330153 23.229738124755016 -10.766603089459059 7.062704297882788 1.011070570879338 0.507299072262775 0.9778548811863625 0.03495255442188598 0.006034141330834599 0.00019940632845590498 0.03351646541536487 0.011280888431947736 1.7115788471542218e-11 10.766603089459059 -0.5037714986165629 HFIMQVVCEATQCPDTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HFIMQVVCEATQCPDTR 17 0 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 0 9442000.0 1372500.0 5219100.0 2850400.0 False True 1799360.7913089062 4440430.623892459 2555467.950967492 1.0 2.4677822509750054 1.42020875597082 20.77905306088552 -10.241165463462309 5.8662566235429345 0.9999666251101388 1.9439955034729128 0.5198548676633175 0.42767008847074023 0.0001866970929399876 2.4152165735714495e-05 0.4141043399492143 0.13802992752651505 5.738977691141477e-11 10.241165463462309 0.944028878362774 HFIMQVVCEATQCPDTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFIMQVVCEATQCPDTR 17 0 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 0 10473200.0 1372500.0 2126500.0 6974200.0 False True 1879950.34041787 2032544.1986048743 5327037.598157664 1.0 1.0811690898989843 2.833605486075544 20.84226312240841 -6.916573433185735 0.849744586000386 0.9563557041346408 3.095076283728999 0.9931751016763398 0.06988125467648176 0.10023027442811495 0.11636888936025948 0.059141816139764734 0.17175041453095716 1.2117877749112163e-07 6.916573433185735 2.1387205795943585 up HFLLEEDKPEEPTAHAFVSTLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HFLLEEDKPEEPTAHAFVSTLTR 23 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 9575800.0 3325400.0 3550300.0 2700100.0 False True 2765217.4401984354 3531173.829220623 3264678.426148157 1.0 1.2769968024529823 1.1806226804044313 21.398961499173634 -10.084428651389494 4.258451075654892 0.9999722649477296 1.2288097414038113 0.8825692304070945 0.039344570700972824 5692197.8300997885 6739840.955883097 1201.4525136203852 0.013468694167788576 8.2332508679978e-11 10.084428651389494 0.22883747645608166 HFLQQATQVNAWDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HFLQQATQVNAWDR 14 0 P37198 P37198 NUP62 Nuclear pore glycoprotein p62 0 12854340.0 4508240.0 5783700.0 2562400.0 False True 5910346.297858261 4920794.504686027 2297267.428276415 1.0 0.8325729587907871 0.3886857575687026 22.494811232310095 -6.954191393874483 0.5107649790381861 1.008118259280186 0.19364117164805636 0.999490462965376 0.005822338199729195 0.08184514033772038 0.029325756849055987 0.006697372240079005 0.03663694413455351 1.1112418942936653e-07 6.954191393874483 -0.8144770876321297 down HFLQQATQVNAWDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HFLQQATQVNAWDR 14 0 P37198 P37198 NUP62 Nuclear pore glycoprotein p62 0 30657000.0 9580900.0 12590000.0 8486100.0 False True 14534925.757612575 10343216.133881018 6808818.615410236 1.0 0.7116112119433307 0.4684453659382581 23.793020366618077 -7.092511376392166 0.17752921116016157 1.202410325559745 1.4989489950654302e-13 0.9999963561970153 0.00041469702412621085 0.07576652770900925 0.0061946542434651785 0.011141996529045118 0.02910264048037027 8.081437594197738e-08 7.092511376392166 -1.202410325559595 down HFLQQATQVNAWDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFLQQATQVNAWDR 14 0 P37198 P37198 NUP62 Nuclear pore glycoprotein p62 0 19035740.0 4508240.0 7833800.0 6693700.0 False True 6175058.158605069 7487676.813087638 5112785.921078818 1.0 1.2125678205400232 0.8279737274950272 22.558021293832986 -6.756641371293527 1.6248918621043125 1.1239827792059605 0.8267860483680144 0.6772133028311456 0.08936915080823307 0.2885870160189087 1.500882443253102 0.04341026280870253 0.10467978302417025 1.7512922617483388e-07 6.756641371293527 -0.29719673083794607 HFNALGGWGELQNSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HFNALGGWGELQNSVK 16 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 20313500.0 6447900.0 6922700.0 6942900.0 False True 8453259.341552421 5889860.144473249 6224515.308999501 1.0 0.6967561157767094 0.7363450069966011 23.011076281044684 -10.601155410961635 9.797493982499319 1.0000350588882503 0.7165505614618538 0.9855805427267617 0.016162097161880634 1.2378453780717474e-05 5.039122495291892e-07 0.015650808880224715 0.0052162944289791515 2.505212609885678e-11 10.601155410961635 -0.2834844974263965 HFNALGGWGELQNSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HFNALGGWGELQNSVK 16 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 15423200.0 4693000.0 2976200.0 7754000.0 False True 4544023.283818322 4164612.1806779657 5722994.784986204 1.0 0.9165032660612735 1.2594554269486922 22.115538796632254 -6.842381955639551 1.2714895593191156 0.9555889905862502 1.2712630755610863 0.9284383913804691 0.039062671556839824 0.1660389857378935 0.5204321328035678 0.024081418085642303 0.05551305856979931 1.4375337322559688e-07 6.842381955639551 0.31567408497483607 HFNALGGWGELQNSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFNALGGWGELQNSVK 16 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 20747300.0 6447900.0 7533500.0 6765900.0 False True 8831862.877945637 7200645.060046933 5167933.768084498 1.0 0.8153030860598982 0.585146513199331 23.074286342567575 -6.9681550970331205 0.29898622691955823 1.0404008161576848 0.35284738139083643 0.9999642035301152 0.0010153122262667898 0.07690600521256832 0.011161401102354617 0.0038377008376283364 0.020663999813100097 1.0760808505782913e-07 6.9681550970331205 -0.6875534347668484 HFNALGGWGELQNSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HFNALGGWGELQNSVK 16 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 12545600.0 4693000.0 3313000.0 4539600.0 False True 3902437.4351510373 3295152.2114209915 5488809.371261128 1.0 0.8443830980453523 1.4065079741755535 21.89594407206653 -6.83287629859894 1.3151286245447553 0.9170023471281045 1.4225295535829747 0.9114841375070696 0.0705063578610764 0.17728916107734566 0.5986881579010913 0.042082069165599936 0.09683717221940166 1.469344735917872e-07 6.83287629859894 0.5055272064548703 HFNALGGWGELQNSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFNALGGWGELQNSVK 16 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 29555800.0 10624000.0 10499000.0 8432800.0 False True 13752977.43034854 9914721.420637278 6898116.927834858 1.0 0.7209145416583448 0.5015726203849402 23.71324065077526 -7.181131789409127 0.15227680971148752 1.262055928042381 1.2833650669594363e-10 0.9999968044910851 0.0003645686285230739 0.08842207276530474 0.0065388008921053635 0.016496133975695965 0.03542780300096992 6.589738951011726e-08 7.181131789409127 -1.2620559279140446 HFNAPSHIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HFNAPSHIR 9 0 P61254;J3QRI7;J3QQQ9;J3QQV1;J3QRC4;J3KSS0 P61254 RPL26 60S ribosomal protein L26 0 377100.0 377100.0 0.0 0.0 False True 494381.75184159493 0.0 0.0 1.0 0.0 0.0 18.91526596724726 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 HFNAPSHIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HFNAPSHIR 9 0 P61254;J3QRI7;J3QQQ9;J3QQV1;J3QRC4;J3KSS0 P61254 RPL26 60S ribosomal protein L26 0 4143400.0 1281700.0 1721800.0 1139900.0 False True 1944432.604821261 1414531.3375151965 914598.2653640809 1.0 0.7274776888681237 0.47036768623212527 20.890917800303463 -6.971829518424021 0.20994145190490665 1.1347126189716172 0.055955711603943775 0.999993353235414 0.0005574963082145786 0.07571341423663805 0.006863881187590869 0.007702839099804957 0.02664644082122642 1.0670148939511661e-07 6.971829518424021 -1.0787569073676735 down HFNAPSHIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFNAPSHIR 9 0 P61254;J3QRI7;J3QQQ9;J3QQV1;J3QRC4;J3KSS0 P61254 RPL26 60S ribosomal protein L26 0 1608730.0 377100.0 648760.0 582870.0 False True 516524.06074432004 620095.6380375717 445208.11058446247 1.0 1.2005164621837814 0.861931020101774 18.978476028770153 -6.746265467787882 1.663812415677602 1.1184334508906775 0.8614509151076051 0.632693741782292 0.08424714294990378 0.3066003561887057 1.6687345125261903 0.0400212520546374 0.09753922921554195 1.793636909284459e-07 6.746265467787882 -0.2569825357830724 HFNAPSHIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HFNAPSHIR 9 0 P61254;J3QRI7;J3QQQ9;J3QQV1;J3QRC4;J3KSS0 P61254 RPL26 60S ribosomal protein L26 0 1586480.0 655110.0 628690.0 302680.0 False True 544752.9912937991 625303.1221848051 365968.9885658024 1.0 1.147865421903784 0.6718072124700386 19.0552426877842 -6.823239283170055 1.357567744521369 1.0794477688766246 0.660652801986141 0.8917384352186641 0.06545857920224546 0.18928968868828222 0.684550442079579 0.037879998997262465 0.08725123706554645 1.5023140082816906e-07 6.823239283170055 -0.4187949668904837 HFNAPSHIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFNAPSHIR 9 0 P61254;J3QRI7;J3QQQ9;J3QQV1;J3QRC4;J3KSS0 P61254 RPL26 60S ribosomal protein L26 0 2601200.0 1281700.0 1319500.0 0.0 False True 1659185.9160841224 1246068.665066279 0.0 1.0 0.7510120794703649 0.0 20.662044122395912 -7.332429781110046 0.798439341911937 0.9892260422572589 5.01279099655373e-19 0.9879742807710451 0.04661185956648638 0.10720660337785552 0.13766972789323442 0.03992465934115326 0.07092738651001716 4.6512557390138626e-08 7.332429781110046 -0.9892260422572589 down HFPSVNWLISYSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HFPSVNWLISYSK 13 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 13254900.0 2996300.0 6637000.0 3621600.0 False True 3928178.316210477 5646785.470823376 3246871.57284026 1.0 1.4375074185203598 0.8265591099674224 21.905428990339693 -6.714479707489748 1.7792026531935834 1.2677317815930196 0.8277949399064718 0.48634154186872214 0.18424004847712178 0.36615328818132964 2.2620675466176676 0.08232136537441569 0.2080094286013816 1.9298355060940049e-07 6.714479707489748 -0.4399368416865478 HFPSVNWLISYSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HFPSVNWLISYSK 13 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 43723000.0 17772000.0 11413000.0 14538000.0 False True 17207837.58790096 15970270.418008734 10730061.669348652 1.0 0.9280811918655966 0.6235566563513529 24.036562477613995 -6.9435694531129055 0.6254808530093217 1.0033239462130121 0.5320285181178606 0.9985949800469651 0.0061161580637103035 0.08617546143409241 0.047473972758648335 0.006128995762263911 0.02582625495732278 1.138755655570021e-07 6.9435694531129055 -0.47129542809515157 HFPSVNWLISYSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HFPSVNWLISYSK 13 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 96110000.0 31483000.0 30282000.0 34345000.0 False True 47762012.715602525 24877940.505654115 27556695.696051706 1.0 0.5208729509325553 0.5769584263573067 25.50936029800092 -10.037654857346308 4.957035322600587 1.0000076538308116 0.5489156886419331 0.9885385316460777 0.022896799476611458 31679536.7502933 5.16216538244128 2767.5448682305537 0.007838183477794025 9.169489185817797e-11 10.037654857346308 -0.4510919651888785 HFPSVNWLISYSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFPSVNWLISYSK 13 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 27641500.0 2996300.0 9830200.0 14815000.0 False True 4104113.0819628914 9395869.259875678 11316002.124502566 1.0 2.2893787457196173 2.7572344861146987 21.968639051862585 -9.855375294904096 0.2607936817739271 1.312178116737779e-11 3.0007570532182086 0.9990291459350198 0.023152694986679632 1.2772064203669453 0.11407475177772103 1.1688701036359104 0.1975649810455313 1.3951622127194665e-10 9.855375294904096 3.0007570532050867 HFPSVNWLISYSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HFPSVNWLISYSK 13 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 41584200.0 17772000.0 9384200.0 14428000.0 False True 14778205.433092736 9333645.451982146 17444828.09246532 1.0 0.6315817907823488 1.1804429280297615 23.81696775304827 -6.725826827509008 1.7381629356173776 0.7772639869415309 1.179891270801957 0.5398991816032925 0.1549321782407823 0.34413917098018476 2.0348396177704378 0.07068927025321821 0.17626443801417951 1.880066333275611e-07 6.725826827509008 0.40262728386042623 HFPSVNWLISYSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFPSVNWLISYSK 13 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 83270000.0 31483000.0 30581000.0 21206000.0 False True 40755364.12270923 28879140.467140533 17346725.5919346 1.0 0.7085972874684447 0.42563048976095047 25.28048662009337 -6.983302592529721 0.22099161025789663 1.1295498042569614 1.7815835722458557e-10 0.9999918539320917 0.0006692512937546543 0.0744868606097556 0.007269802708285057 0.0077582146747457136 0.028219592601958516 1.0391958589609205e-07 6.983302592529721 -1.129549804078803 down HFQEISWFLCPFHLSVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HFQEISWFLCPFHLSVAR 18 0 Q6DKI1 Q6DKI1 RPL7L1 60S ribosomal protein L7-like 1 0 52138000.0 15888000.0 14847000.0 21403000.0 False True 24103257.568385884 12197436.849859532 17172687.668731846 1.0 0.506049309528096 0.7124633514789198 24.522724804864257 -10.240144523308523 5.548739569629771 1.0000237493539434 0.6092563305034915 0.8269290790516943 0.08426817975421921 2.4759322454886097e-05 3.3905818624853726e-06 0.0815972660782087 0.02719743806693339 5.7524847589572256e-11 10.240144523308523 -0.39076741885045196 HFQEISWFLCPFHLSVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFQEISWFLCPFHLSVAR 18 0 Q6DKI1 Q6DKI1 RPL7L1 60S ribosomal protein L7-like 1 0 35381700.0 15888000.0 9305700.0 10188000.0 False True 20567329.199301343 8787829.614632271 8333888.537707709 1.0 0.42727130632648147 0.4052003280032492 24.293851126956707 HFSSLEAEAQKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 HFSSLEAEAQKK 12 1 Q9UPV0-2;Q9UPV0 Q9UPV0-2 CEP164 Centrosomal protein of 164 kDa 1 9217180.0 948980.0 1757100.0 6511100.0 True False 1439672.0397310453 1443531.7767150383 5224178.231083485 1.0 1.0026809835000436 3.628727992841654 20.457308769504657 -6.907117569437639 0.9151214774291376 0.9110958311998208 3.9480011462984166 0.9897880558290643 0.12516193183271906 0.1063556368960704 0.14932765733770526 0.10103318982019172 0.27363600760599904 1.2384612727930728e-07 6.907117569437639 3.0369053150985956 up HFSTEDGIFQGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HFSTEDGIFQGQR 13 0 Q6RFH5;Q6RFH5-2;E9PS41 Q6RFH5 WDR74 WD repeat-containing protein 74 0 11937370.0 839770.0 3853100.0 7244500.0 False True 1100946.6023442477 3278232.4992661686 6494908.634150998 1.0 2.9776489543505757 5.899385692567992 20.070313066926442 -6.965508527173627 0.3492146533563088 0.7150857906190043 8.260419969774842 0.9999232476614243 0.01763124393970964 0.07778881763081082 0.014253850940397004 0.04018616794810706 0.251262668520767 1.0826584574147016e-07 6.965508527173627 7.545334179155838 HFSTEDGIFQGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HFSTEDGIFQGQR 13 0 Q6RFH5;Q6RFH5-2;E9PS41 Q6RFH5 WDR74 WD repeat-containing protein 74 0 10380400.0 3428600.0 1030800.0 5921000.0 False True 3319760.969720753 1442403.8155509864 4370112.4738075 1.0 0.4344902626143944 1.3163937143869424 21.66264793733821 -6.733537569279378 1.710427740069705 0.6610219437619338 1.316206732250196 0.5755260948799983 0.23766816109642247 0.32965551489505057 1.8909679083236954 0.11004585940351869 0.2719744971134654 1.846981012204636e-07 6.733537569279378 0.6551847884882622 HFSTEDGIFQGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFSTEDGIFQGQR 13 0 Q6RFH5;Q6RFH5-2;E9PS41 Q6RFH5 WDR74 WD repeat-containing protein 74 0 9893470.0 839770.0 4611500.0 4442200.0 False True 1150255.6629309396 4407748.681808777 3393043.849980784 1.0 3.8319730333493824 2.949817122686489 20.133523128449333 -10.279608328025866 5.810286821714299 0.9998440884533374 3.390895078017951 0.9073576758551705 0.36013864245077404 0.0007274001284601071 9.018968036721413e-05 0.3487239401240987 0.11623424704479145 5.252809755716742e-11 10.279608328025866 2.3910509895646137 HFSVEGQLEFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HFSVEGQLEFR 11 0 P08238;Q58FF7;P07900;P07900-2;Q14568;Q58FG1 P08238;Q58FF7;P07900;Q58FG1 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA2P;HSP90AA4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-alpha A4 0 40886100.0 12385300.0 14250600.0 14250200.0 False True 16237248.239415826 12124466.028403737 12775726.001570629 1.0 0.7467069450211191 0.7868159563242759 23.952803820889336 -10.042554448168755 4.904719811766273 1.0000046967577956 0.7667614506701115 0.9783021073082178 0.01637443530584172 8.409786499995778e-07 1.6416287488678318e-07 0.015854797939783713 0.005284826268953744 9.066622878093e-11 10.042554448168755 -0.2332432460876841 HFSVEGQLEFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HFSVEGQLEFR 11 0 P08238;Q58FF7;P07900;P07900-2;Q14568;Q58FG1 P08238;Q58FF7;P07900;Q58FG1 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA2P;HSP90AA4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-alpha A4 0 104594800.0 33202100.0 26316700.0 45076000.0 False True 32148117.509410653 36825095.54977749 33269243.34898612 1.0 1.1454821744693995 1.0348737632692577 24.938230924646493 -10.67460160305075 6.718288436720616 0.9994125374985215 1.0901779688693263 0.4698516371057395 0.04515569478338187 0.00039988794443061024 1.9368437056510633e-05 0.044003098308639146 0.01457393782353861 2.1154287234932395e-11 10.67460160305075 0.09076543137080473 HFSVEGQLEFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HFSVEGQLEFR 11 0 P08238;Q58FF7;P07900;P07900-2;Q14568;Q58FG1 P08238;Q58FF7;P07900;Q58FG1 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA2P;HSP90AA4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-alpha A4 0 1335216100.0 234288000.0 560609200.0 540318900.0 False True 355432024.74710464 460564108.2003287 433524632.5848129 1.0 1.2957867500207028 1.2197117940997926 28.404998434450725 -10.025923717973274 4.267131667124135 0.999982370779851 1.2577492720800365 0.9386713543473518 0.031057470940848618 21629773.699932303 36823377.37918294 5271.262580527162 0.011365869073170344 9.420550500589777e-11 10.025923717973274 0.25776690130018554 HFSVEGQLEFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFSVEGQLEFR 11 0 P08238;Q58FF7;P07900;P07900-2;Q14568;Q58FG1 P08238;Q58FF7;P07900;Q58FG1 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA2P;HSP90AA4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-alpha A4 0 44407000.0 12385300.0 15707600.0 16314100.0 False True 16964480.11014752 15013586.293912949 12461045.579436181 1.0 0.8850012612489304 0.7345374275267326 24.016013882412228 -6.9674286274172355 0.31358423679293385 1.0222206161615106 0.5925103064925875 0.9999548103022781 0.000730671060056135 0.07714621853538754 0.012002342936761307 0.0023430830298117964 0.013312745418977246 1.0778823798873183e-07 6.9674286274172355 -0.4297103096689231 HFSVEGQLEFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HFSVEGQLEFR 11 0 P08238;Q58FF7;P07900;P07900-2;Q14568;Q58FG1 P08238;Q58FF7;P07900;Q58FG1 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA2P;HSP90AA4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-alpha A4 0 82382800.0 33202100.0 34366400.0 14814300.0 False True 27609017.252424493 34181261.382003725 17911901.636415917 1.0 1.2380470144768405 0.6487699823811359 24.71863620008077 -6.7970714287900655 1.4680515326728183 1.1318328879302384 0.6412307637206084 0.8233994740986369 0.10171707842221475 0.2249671704961698 0.9575096152384275 0.05451844191893817 0.12701080360522213 1.595616693193029e-07 6.7970714287900655 -0.49060212420963 HFSVEGQLEFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFSVEGQLEFR 11 0 P08238;Q58FF7;P07900;P07900-2;Q14568;Q58FG1 P08238;Q58FF7;P07900;Q58FG1 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AA2P;HSP90AA4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-alpha A4 0 1057946500.0 234288000.0 485801500.0 337857000.0 False True 303290434.5069183 458766219.47116065 276370492.705567 1.0 1.5126300313988168 0.9112403863144677 28.176124756543174 -6.680977855595768 1.8986961324816631 1.324073909351804 0.913529946901603 0.328423193636208 0.21722059449296097 0.43638793467815085 3.0425439584456453 0.09177728824815622 0.24172853881827802 2.0845971726945707e-07 6.680977855595768 -0.41054396245020086 HFTEDIQTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFTEDIQTR 9 0 H3BLV9;Q96SB4-4;Q96SB4;Q96SB4-3;H7C2I2;H7C521;H7C5L6;A8MPP7;A8MPY5;E7ETV6;Q9UPE1-2;Q9UPE1-3;Q9UPE1-4;Q9UPE1;P78362;P78362-2 H3BLV9;P78362 SRPK1;SRPK3;SRPK2 SRSF protein kinase 1;SRSF protein kinase 3;SRSF protein kinase 2;SRSF protein kinase 2 N-terminal;SRSF protein kinase 2 C-terminal 0 8041400.0 2381200.0 1984200.0 3676000.0 False True 3082510.340469311 1873777.5257480217 3007005.718945186 1.0 0.6078738816048026 0.9755054766458207 21.555674303569084 -10.537154654877817 9.03781302422633 1.0000136647313715 0.7916896801623957 0.2997638134730639 0.15008497019599878 4.132686463145432e-05 2.11638951473706e-06 0.14532866846482365 0.04843971584042831 2.902988698635828e-11 10.537154654877817 -0.20832398456897583 HFTILDAPGHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HFTILDAPGHK 11 0 P15170-2;P15170-3;P15170;H3BR35;H3BSV8;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 31485900.0 5953900.0 15520000.0 10012000.0 False True 7805620.55764962 13204476.496486176 8976054.281885533 1.0 1.6916626165674424 1.1499475558146202 22.89608190234157 -10.269363423338728 3.6160474653122416 0.9990952370949278 1.4208050852351457 0.4458485290995009 0.2211542507931571 53312453.16447354 91861866.74968792 571986.611686453 0.08093416597068537 5.378195396882998e-11 10.269363423338728 0.42170984814021795 HFTILDAPGHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HFTILDAPGHK 11 0 P15170-2;P15170-3;P15170;H3BR35;H3BSV8;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 23907200.0 8362300.0 5483900.0 10061000.0 False True 8096843.363791589 7673649.868160704 7425722.2764697205 1.0 0.9477335207541039 0.9171132431284189 22.948928137690295 -13.999999999827223 0.05807199722945773 1.339891686999329 0.7723645736224956 0.9999589481533222 0.0002191828473344331 12.484014802896112 0.060869498001786454 0.6276841610530761 0.1362097623522614 1.0000000003978345e-14 13.999999999827223 -0.5675271133768334 HFTILDAPGHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HFTILDAPGHK 11 0 P15170-2;P15170-3;P15170;H3BR35;H3BSV8;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 75715000.0 25039000.0 35408000.0 15268000.0 False True 37985993.59609861 29089165.756033283 12250273.107797863 1.0 0.7657866229678119 0.32249447620230315 25.178964222388714 -6.961109100785488 0.4195120889237942 1.0196975286440397 0.05187490009860571 0.9998091427798417 0.003881299724683958 0.0793073070450829 0.019684990753847463 0.005732606538103857 0.03690567897977691 1.0936815838060403e-07 6.961109100785488 -0.967822628545434 down HFTILDAPGHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFTILDAPGHK 11 0 P15170-2;P15170-3;P15170;H3BR35;H3BSV8;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 38807900.0 5953900.0 15335000.0 17519000.0 False True 8155217.7280976055 14657448.993936384 13381373.01513062 1.0 1.7973093401830702 1.640835776711033 22.959291963864462 -10.060573832977134 4.466668457856913 0.9999549117459944 1.719072558495887 0.9657041262176913 0.06388006497507255 44642611.34370397 60281136.80384334 26732.958430522263 0.023377704317058996 8.698135463532358e-11 10.060573832977134 0.7191176467498926 HFTILDAPGHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HFTILDAPGHK 11 0 P15170-2;P15170-3;P15170;H3BR35;H3BSV8;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 19237700.0 8362300.0 6609400.0 4266000.0 False True 6953622.96270264 6573793.850336811 5158000.876244599 1.0 0.9453768036600301 0.7417717215774748 22.72933341312457 -6.946497862893786 0.5960578102104035 1.0023146581140814 0.6744816499087627 0.9988969668041597 0.003690368458835995 0.08492335051154871 0.0420233576377027 0.003802452173251098 0.017088822161458697 1.1311029553293792e-07 6.946497862893786 -0.3278330082053187 HFTILDAPGHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFTILDAPGHK 11 0 P15170-2;P15170-3;P15170;H3BR35;H3BSV8;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 61748000.0 25039000.0 18899000.0 17810000.0 False True 32413479.092479028 17847254.036443807 14568762.746032014 1.0 0.5506121075594427 0.4494661836350803 24.950090544481164 -13.999999999999998 0.20954917944499504 3.5941662940118624 0.3896302799517108 0.9994897632728462 0.005404813512247926 12.736154774495112 0.1450953933175247 13.600067197130521 0.060103585962832044 1.0000000000000041e-14 13.999999999999998 -3.2045360140601518 HFTVMNYDPDVVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HFTVMNYDPDVVLK 14 0 Q14166 Q14166 TTLL12 Tubulin--tyrosine ligase-like protein 12 0 10652600.0 3761500.0 4922800.0 1968300.0 False True 4931362.92641782 4188337.4289241056 1764639.197266809 1.0 0.8493265434768043 0.3578400583362978 22.233555002020374 -6.949555266290577 0.5637059722511435 1.0063076216887803 0.17722018203959458 0.9991659115710134 0.007918821880712537 0.08366484442079945 0.036705389356916696 0.008451026874459224 0.04088954688977916 1.123168031453534e-07 6.949555266290577 -0.8290874396491857 down HFTVMNYDPDVVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFTVMNYDPDVVLK 14 0 Q14166 Q14166 TTLL12 Tubulin--tyrosine ligase-like protein 12 0 13602000.0 3761500.0 4134500.0 5706000.0 False True 5152228.200715356 3951824.119036842 4358360.318758804 1.0 0.767012633192015 0.8459175620663837 22.296765063543265 -10.571301461107739 8.941067843444342 1.0000284273631237 0.8064650976291994 0.8891522053162795 0.032212802322133735 1.8256602458468424e-05 8.753574121496666e-07 0.03119448233550997 0.010396637244024627 2.6834810878505655e-11 10.571301461107739 -0.19356332973392432 HFTVMNYDPDVVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HFTVMNYDPDVVLK 14 0 Q14166 Q14166 TTLL12 Tubulin--tyrosine ligase-like protein 12 0 8135650.0 2177600.0 975250.0 4982800.0 False True 1810770.8840368441 969996.1346780309 6024680.442135861 1.0 0.5356813185087055 3.3271356941109707 20.7881725836549 -6.864166165437393 1.1645823332484548 0.7447314567350309 3.4734226037700884 0.9585019099569386 0.24878464869351177 0.14256718068576596 0.3650907635269168 0.16631940542374618 0.3902261245661038 1.3672056188874974e-07 6.864166165437393 2.7286911470350574 up HFVALSTNTTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HFVALSTNTTK 11 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90 P06744 GPI Glucose-6-phosphate isomerase 0 262286300.0 97395000.0 70311400.0 94579900.0 False True 127685788.17452155 59821213.19169056 84793679.22246353 1.0 0.46850330053902817 0.6640807910945197 26.928022716628654 -10.090887312353273 5.128816023212785 1.000009430303452 0.5662920458158144 0.8676698679304733 0.07984417617583642 8.609863231869587e-06 1.526076471355686e-06 0.07731047094197784 0.025769597051241697 8.111715075694933e-11 10.090887312353273 -0.4337173844876375 HFVALSTNTTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HFVALSTNTTK 11 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90 P06744 GPI Glucose-6-phosphate isomerase 0 148311170.0 42333170.0 23760000.0 82218000.0 False True 40989326.69035571 33247491.9067631 60682639.312870204 1.0 0.8111255927164529 1.480449771016807 25.28874495600265 -6.831347686115959 1.321953054840424 0.8991707996698745 1.4989521070339111 0.9085310112244309 0.08521517011038042 0.17915315715101018 0.6118394096531319 0.050606582935102104 0.11645277898554557 1.4745255895431092e-07 6.831347686115959 0.5997813073640367 HFVALSTNTTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HFVALSTNTTK 11 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90 P06744 GPI Glucose-6-phosphate isomerase 0 199499300.0 84119300.0 115380000.0 0.0 False True 127615128.04458222 94789537.53194547 0.0 1.0 0.7427766518310497 0.0 26.92722412159684 -7.347198719589761 0.7897770791017086 0.9894116346933015 8.628408566578396e-23 0.9878455810342656 0.04674327435798984 0.10862329494053852 0.13786282802986044 0.04012613165015205 0.07141498342315193 4.4957409675836926e-08 7.347198719589761 -0.9894116346933015 down HFVALSTNTTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFVALSTNTTK 11 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90 P06744 GPI Glucose-6-phosphate isomerase 0 229164000.0 97395000.0 56036100.0 75732900.0 False True 133404563.50090955 53560239.81539735 57846348.78803506 1.0 0.40148731355080053 0.433615966875381 26.991232778151545 -9.971190547812622 5.357025714832553 1.0000016082272267 0.41755164023025254 0.9977231125015491 0.013116467801659459 2.811011954506877e-07 5.394368752967631e-08 0.012700004503352286 0.004233321778727706 1.068585931548784e-10 9.971190547812622 -0.5824499679969741 HFVALSTNTTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HFVALSTNTTK 11 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90 P06744 GPI Glucose-6-phosphate isomerase 0 128186170.0 42333170.0 55468000.0 30385000.0 False True 35201906.532412715 55169182.874464005 36738363.01563341 1.0 1.567221446476659 1.0436469678653906 25.069150231436925 -10.415117226389222 3.598195843141755 0.9976002619285286 1.3054342072415794 0.31212406774449486 0.21374838608136312 50447300.05303815 3244.9885945353567 1003522.8284120992 0.07608037108840988 3.8448798560377427e-11 10.415117226389222 0.30783394531305086 HFVALSTNTTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFVALSTNTTK 11 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90 P06744 GPI Glucose-6-phosphate isomerase 0 241732100.0 84119300.0 87396800.0 70216000.0 False True 108894092.08929941 82533091.25203837 57437408.47700082 1.0 0.7579207436190064 0.5274611999143062 26.69835044368929 -6.9717226663287 0.21306811836995096 1.116034823278467 0.16289128498059965 0.9999928808489619 0.0005147453110219796 0.07574764478053692 0.006994239449628136 0.006736026606125509 0.023714559295290597 1.0672774503701043e-07 6.9717226663287 -0.9531435382978672 HFVALSTNTTK(ub)VK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HFVALSTNTTKVK 13 1 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90 P06744 GPI Glucose-6-phosphate isomerase 1 3911410.0 485310.0 1573400.0 1852700.0 True False 403556.76787836134 1564923.781904553 2240091.0040830653 1.0 3.8778281185368373 5.550869623275072 18.622412104509934 -8.504875963627574 0.29111667131276403 6.980535830304373e-20 6.504110039760486 0.9988572408641679 0.06353466776820589 0.17467191755980094 0.0811306991661092 0.6892398415549267 0.5549446339206543 3.1269723163490254e-09 8.504875963627574 6.504110039760486 HFVDSHHQKPVNAIIEHVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFVDSHHQKPVNAIIEHVR 19 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 16820900.0 2241900.0 10711000.0 3868000.0 False True 2902183.744455793 10114923.434274293 3164063.6890315455 1.0 3.4852801631176553 1.0902354804639909 21.468707432224118 -6.637590397887266 2.0534596168179133 2.6282603835783207 1.100223628688844 0.14524240609289663 1.0640365694719933 0.5395415485107157 4.34526724619683 0.42243518013287423 1.1780422979616312 2.3036134317140964e-07 6.637590397887266 -1.5280367548894767 HFVGMLPEKDCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HFVGMLPEKDCR 12 1 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 19119000.0 2635100.0 8035300.0 8448600.0 False True 3997639.3516146573 6601337.934914542 6778730.506847078 1.0 1.6513090237237744 1.6956833547551333 21.930716894056513 -11.348702571104614 0.45194138637002346 2.2389761076174107e-08 1.6958579651351142 0.9997548608715885 0.004978984190807217 3.633861079425782 0.22268187202966755 3.6170448680572758 0.00996183670173457 4.480200280425996e-12 11.348702571104614 1.695857942745353 HFVGMLPEKDCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFVGMLPEKDCR 12 1 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 15820600.0 2635100.0 4808200.0 8377300.0 False True 3411188.895586543 4540619.443252514 6852717.358356778 1.0 1.3310958678152502 2.0088941328411765 21.701843216148962 -6.959587207869521 0.4412209151703301 0.9760710065869513 2.39039863291248 0.9997545598597798 0.006578493843242184 0.07984902531627595 0.021679407973051103 0.008950095510715253 0.056146947737235414 1.0975208820663529e-07 6.959587207869521 1.4143276263255287 up HFVLDECDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HFVLDECDK 9 0 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 20901300.0 5346100.0 12816000.0 2739200.0 False True 8110424.552262569 10528884.668134967 2197795.9193659876 1.0 1.2981915558535981 0.27098407798551893 22.95134600576579 -6.829044354808466 1.3322725522168175 1.1594391008457778 0.24389732499483563 0.9039318455688077 0.13373514732483427 0.1819935685723462 0.632113867234324 0.07882516524804845 0.18139771198553237 1.4823666822369298e-07 6.829044354808466 -0.9155417758509422 down HFVLDECDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFVLDECDK 9 0 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 4538100.0 1862900.0 2675200.0 0.0 False True 2551664.4729795638 2557000.81829662 0.0 1.0 1.0020913193617595 0.0 21.283007206031726 -7.021930115723975 1.0894866777847043 1.0225978107793567 1.2386773660632491e-17 0.9857623332242739 0.05630769516416609 0.08810892358831723 0.2032018022889225 0.043542428575688144 0.07893288360744287 9.50757772051836e-08 7.021930115723975 -1.0225978107793567 down HFVLDECDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFVLDECDK 9 0 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 12610200.0 5346100.0 4636800.0 2627300.0 False True 6920631.837385752 4378758.003925217 2149158.3583745076 1.0 0.6327107274036528 0.31054366261250876 22.722472327858238 -7.567175818694303 0.2606813407729172 1.1268018729550051 2.408285831324277e-15 0.9998060631624823 0.00392256937658263 0.12838084424411453 0.028863102350195655 0.02991792433034309 0.07015061093660724 2.7090946667349757e-08 7.567175818694303 -1.1268018729550027 down HFVTISSPLATQIPQAVGAAYAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFVTISSPLATQIPQAVGAAYAAK 24 0 H0YH31;F5GXU9;F5H5P2;P12694;P12694-2 H0YH31 BCKDHA 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 0 4781590.0 1395100.0 827590.0 2558900.0 False True 1910906.171159908 791024.3373258442 1954540.5221997711 1.0 0.4139524741006501 1.0228343765373773 20.865825510525152 -10.95653575056844 12.595257057115262 1.0798361150405502 0.7183934253190601 0.22191443110387277 0.24857499576417852 0.11274752059111903 0.0003890733753623039 0.04869499213711223 0.0802272349065202 1.1052594820854994e-11 10.95653575056844 -0.3614426897214901 HFVTISSPLATQIPQAVGAAYAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HFVTISSPLATQIPQAVGAAYAAK 24 0 H0YH31;F5GXU9;F5H5P2;P12694;P12694-2 H0YH31 BCKDHA 2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial 0 9381800.0 4323900.0 2484400.0 2573500.0 False True 3595514.4312485815 2471016.0440852134 3111606.9514804212 1.0 0.6872496526810286 0.8654135620865473 21.77776676956192 -10.173130747026608 5.194246861472596 1.0000113407348654 0.7763316081897702 0.677564855909734 0.07273511143763232 9.552817566259343e-06 1.5207728890012853e-06 0.07042903777356062 0.023475156273473154 6.712267455618825e-11 10.173130747026608 -0.2236797325450952 HFWGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HFWGLR 6 0 P62269;J3JS69 P62269 RPS18 40S ribosomal protein S18 0 48167000.0 12911000.0 12438000.0 22818000.0 False True 16926446.030301835 10582298.882944278 20457012.24571156 1.0 0.6251931955473569 1.2085828418493334 24.012775753056502 -6.733219476623198 1.7116893934316035 0.7752567138768656 1.208433338507055 0.5740816049633897 0.15752318052723716 0.3302143453983547 1.8968501736451076 0.07288913989711547 0.1802002947430748 1.8483343020346504e-07 6.733219476623198 0.43317662463018936 HFWGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HFWGLR 6 0 P62269;J3JS69 P62269 RPS18 40S ribosomal protein S18 0 27226000.0 8322800.0 5170200.0 13733000.0 False True 8058597.269670399 7234687.822236819 10135915.318830999 1.0 0.8977601907797934 1.2577766303049864 22.942097305321827 -6.830851007156355 1.32431992388572 0.9454034731024968 1.2676188631213103 0.9075244328751659 0.04606452310874499 0.17976591421686705 0.6163346236757693 0.027309773051298204 0.06283915356075888 1.4762128888513483e-07 6.830851007156355 0.3222153900188135 HFWGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HFWGLR 6 0 P62269;J3JS69 P62269 RPS18 40S ribosomal protein S18 0 586712000.0 67692000.0 381530000.0 137490000.0 False True 102693712.94808508 313442990.5925039 110315041.23599228 1.0 3.0522120740824636 1.0742141662728664 26.6137726196619 -6.637481194019178 2.0527951023610096 2.3444898005532413 1.082240142730426 0.14538434533429512 0.8786130114499752 0.5396698946923709 4.342944205868437 0.34886051683614594 0.973378281015914 2.3041927509051726e-07 6.637481194019178 -1.2622496578228153 HFWGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFWGLR 6 0 P62269;J3JS69 P62269 RPS18 40S ribosomal protein S18 0 60199000.0 12911000.0 15320000.0 31968000.0 False True 17684545.60665581 14643111.743534768 24417816.801626567 1.0 0.8280174152749303 1.380743240156343 24.075985814579393 -6.823101674083693 1.358292611019898 0.9075812585590257 1.3936430776957598 0.8913952186195849 0.07611077078777563 0.1894777494125784 0.6860230273795396 0.04402218016789045 0.10139538398810874 1.5027901018596532e-07 6.823101674083693 0.4860618191367341 HFWGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HFWGLR 6 0 P62269;J3JS69 P62269 RPS18 40S ribosomal protein S18 0 22117800.0 8322800.0 13795000.0 0.0 False True 6920776.962555954 13720683.596906906 0.0 1.0 1.9825351504810866 0.0 22.722502580756103 -6.778260137465137 1.5840602922697642 1.5618160353346904 7.831417049965274e-12 0.7376997535831223 0.41452453170078585 0.2588456155564925 1.2893926111281453 0.20752293777738473 0.48215385871814154 1.6662488494290188e-07 6.778260137465137 -1.5618160353268589 HFWGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFWGLR 6 0 P62269;J3JS69 P62269 RPS18 40S ribosomal protein S18 0 769572000.0 67692000.0 249950000.0 451930000.0 False True 87628628.40880571 236040062.77629128 369683377.19338846 1.0 2.693640960293427 4.218751153661095 26.38489894175435 -6.9723695992805075 0.1933859499603203 0.0110021444140291 6.943201606391813 0.9999954480093322 0.002804851558414865 0.07554110360093089 0.006194249334429699 0.05231925270614488 0.16472518629260344 1.0656887980230021e-07 6.9723695992805075 6.932199461977785 HFYVVIPQIYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HFYVVIPQIYK 11 0 A0A075B6Q2;S4R347;Q5T0N5-3;Q5T0N5-4;Q5T0N5-2;Q5T0N5-5;Q5T0N5 A0A075B6Q2 FNBP1L Formin-binding protein 1-like 0 7744700.0 2316600.0 2503700.0 2924400.0 False True 3037085.033986312 2130157.719346163 2621811.1408256134 1.0 0.7013823108371234 0.8632656351357958 21.53425587176861 -10.075966713739813 4.869365577928413 1.0000068921469638 0.7823239734522505 0.7068110390067226 0.06608859040646016 4.945015117845508e-06 9.383370245367604e-07 0.06399202840088815 0.021330000833892766 8.395243289311422e-11 10.075966713739813 -0.21768291869471335 HFYVVIPQIYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HFYVVIPQIYK 11 0 A0A075B6Q2;S4R347;Q5T0N5-3;Q5T0N5-4;Q5T0N5-2;Q5T0N5-5;Q5T0N5 A0A075B6Q2 FNBP1L Formin-binding protein 1-like 0 6500100.0 2393700.0 1831000.0 2275400.0 False True 2317713.3037451333 2562127.8485388625 1679404.4794631964 1.0 1.105455038118298 0.7245954349701017 21.14427068836668 -6.832842337958368 1.315044603359711 1.056249343261437 0.7137306902563492 0.9114527787710794 0.04777836017731496 0.17733679064301464 0.5987478367879591 0.028516625484003934 0.06562921255359432 1.4694596391496652e-07 6.832842337958368 -0.3425186530050879 HFYVVIPQIYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HFYVVIPQIYK 11 0 A0A075B6Q2;S4R347;Q5T0N5-3;Q5T0N5-4;Q5T0N5-2;Q5T0N5-5;Q5T0N5 A0A075B6Q2 FNBP1L Formin-binding protein 1-like 0 8069200.0 2316600.0 1660300.0 4092300.0 False True 3173109.623761048 1586942.456122113 3125783.0235640774 1.0 0.5001221654110801 0.9850851039489538 21.597465933291502 -10.820486221433955 10.38428826151732 1.0035194887912828 0.742603634680017 0.2730448879735019 0.1979852905964184 0.016237836400551844 0.00028070390207190625 0.19295468951848155 0.06389947777283037 1.511867664598435e-11 10.820486221433955 -0.26091585411126583 HFYVVIPQIYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HFYVVIPQIYK 11 0 A0A075B6Q2;S4R347;Q5T0N5-3;Q5T0N5-4;Q5T0N5-2;Q5T0N5-5;Q5T0N5 A0A075B6Q2 FNBP1L Formin-binding protein 1-like 0 5068900.0 2393700.0 1472800.0 1202400.0 False True 1990467.6088900557 1464865.734072089 1453816.2807305446 1.0 0.7359405033920355 0.7303893186894089 20.924675963800958 HFYWYLTNEGIQYLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HFYWYLTNEGIQYLR 15 0 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 0 33386200.0 12013300.0 13629300.0 7743600.0 False True 11631944.367247956 19071550.56586057 5715318.856979526 1.0 1.6395840595283708 0.4913468184280642 23.471588938539778 -6.75554007903701 1.6294409249666482 1.373557739636287 0.4880760766964646 0.6724515929769556 0.26886412331809095 0.2904624327196756 1.518895750783903 0.13026222728440953 0.3144119983498431 1.7557388576716903e-07 6.75554007903701 -0.8854816629398224 HFYWYLTNEGIQYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HFYWYLTNEGIQYLR 15 0 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 0 243037000.0 64226000.0 83036000.0 95775000.0 False True 97435537.54954387 68217577.03677085 76845029.27032617 1.0 0.700130350305541 0.7886755818558718 26.537944724974594 -10.234038087085302 7.717751180122191 1.000000313366345 0.7444029660807066 0.9174246512755423 0.03614843940914945 1.9493094463722751e-07 1.9327319977921842e-08 0.035000619243288136 0.011666858651918641 5.833939391081683e-11 10.234038087085302 -0.25559734728563854 HFYWYLTNEGIQYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HFYWYLTNEGIQYLR 15 0 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 0 23071400.0 12013300.0 7012200.0 4045900.0 False True 9989591.229426797 6974423.886787284 4891878.983872018 1.0 0.6981690968737944 0.48969761339801227 23.251994213974054 -7.979916656527744 0.13364628225737854 1.3946068428592049 7.53437409521455e-10 0.9999698102821082 0.0011510264216930488 0.10956268557095987 0.02186417789853782 0.09511413162268487 0.11458689806388807 1.0473295169952135e-08 7.979916656527744 -1.3946068421057676 down HFYWYLTNEGIQYLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HFYWYLTNEGIQYLR 15 0 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 0 218236700.0 64226000.0 81515700.0 72495000.0 False True 83141823.0837317 76979279.6369408 59301653.86151551 1.0 0.9258791397852243 0.7132590032551142 26.309071047067043 -6.952453261318264 0.5312277648280508 1.003324058754228 0.6261416515069423 0.9993800128650897 0.003025987382730592 0.08251532735346429 0.03199914761505456 0.0033698594263467 0.0175853860500266 1.1156982160998278e-07 6.952453261318264 -0.3771824072472857 HGADVNAK(ub)DMLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGADVNAKDMLK 12 1 H9ZYI9;Q06547-4;Q06547-3;Q06547-2;Q06547;F5H7I4 H9ZYI9 GABPB1 GA-binding protein subunit beta-1 1 14582500.0 3046100.0 5130300.0 6406100.0 True False 4621156.399739448 4214757.881783147 5139931.527106625 1.0 0.9120569652264497 1.1122608893731505 22.13982248663866 -6.787343242438578 1.507314238764821 0.9506778353457659 1.114225807525447 0.7924768781904805 0.03732462939535302 0.23933916283105636 1.0743432193160432 0.019495504314259983 0.04572617640731766 1.631761783483983e-07 6.787343242438578 0.1635479721796811 HGADVNAK(ub)DMLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGADVNAKDMLK 12 1 H9ZYI9;Q06547-4;Q06547-3;Q06547-2;Q06547;F5H7I4 H9ZYI9 GABPB1 GA-binding protein subunit beta-1 1 3561340.0 711640.0 1137000.0 1712700.0 True False 974752.5393478869 1086763.5804438007 1308195.5341637202 1.0 1.1149122844766832 1.3420796369906436 19.89467648245914 -6.9602717560386544 0.43158825698938447 0.9911271068763424 1.4745991686853444 0.999780140566565 0.002107562332580468 0.07960420936949597 0.020773808986845305 0.0029668292318341745 0.018855066547858786 1.0957922989572971e-07 6.9602717560386544 0.48347206180900193 HGADVNAK(ub)DMLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGADVNAKDMLK 12 1 H9ZYI9;Q06547-4;Q06547-3;Q06547-2;Q06547;F5H7I4 H9ZYI9 GABPB1 GA-binding protein subunit beta-1 1 1386630.0 455790.0 563630.0 367210.0 True False 379009.57992062444 560593.6133182045 443991.9132127936 1.0 1.4791014344165365 1.1714530099892946 18.531874789137415 -10.164733218438332 4.8264390239153085 0.9999697444028114 1.3252772222022082 0.5984767858514684 0.12559694334105695 4.090124266962934e-05 7.078644602860555e-06 0.1216200174249612 0.040536239157199026 6.843318945474696e-11 10.164733218438332 0.32530747779939684 HGADVNAK(ub)DMLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 HGADVNAKDMLK 12 1 H9ZYI9;Q06547-4;Q06547-3;Q06547-2;Q06547;F5H7I4 H9ZYI9 GABPB1 GA-binding protein subunit beta-1 1 21726500.0 5334100.0 5566000.0 10826400.0 True False 6905097.600830401 5256247.207092771 8856106.288244875 1.0 0.7612125868373909 1.2825461420240964 22.71923037587685 -6.7821516954083245 1.527281463226401 0.8651695301541553 1.2869725881484904 0.7749830763984125 0.10107808393627148 0.24725330800776904 1.1392615217630815 0.05211655406176335 0.12276448856443672 1.6513848826344393e-07 6.7821516954083245 0.42180305799433504 HGDLPDIQIK(ub)HSSLITPLQAVAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGDLPDIQIKHSSLITPLQAVAQR 24 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 8128000.0 1582600.0 3897500.0 2647900.0 True False 2074803.925920201 3316008.192336009 2373920.70845033 1.0 1.5982272594097384 1.1441662890614914 20.98454357399176 -10.203794914337909 5.301799471370453 0.9999777010460441 1.3711967742357045 0.47120283539639074 0.1853696149113483 4.886253177034856e-05 7.33765027287015e-06 0.17949412589471828 0.059827785953665905 6.25467986035874e-11 10.203794914337909 0.3712190731896604 HGDLPDIQIK(ub)HSSLITPLQAVAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGDLPDIQIKHSSLITPLQAVAQR 24 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 23478200.0 6802800.0 7384000.0 9291400.0 True False 6586848.837664455 10332469.707051303 6857703.603974839 1.0 1.5686514085413503 1.041120537754199 22.65115701125721 -10.370194666944213 3.396592846155927 0.9977985683100302 1.3048859731595348 0.3081341067023563 0.21536357738044692 77569442.17227021 117653445.61352623 1716900.9425308534 0.07881501232260255 4.26388352837917e-11 10.370194666944213 0.3070874048495046 HGDLPDIQIK(ub)HSSLITPLQAVAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGDLPDIQIKHSSLITPLQAVAQR 24 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 98200000.0 13731000.0 23170000.0 61299000.0 True False 20830930.87056311 19035132.471963707 49183225.7816938 1.0 0.9137917354842214 2.361067111561312 24.3122239746577 -6.89274744423074 1.0059647141369827 0.9272805299026728 2.492470305722108 0.982600134898187 0.08743790775323841 0.11694317883254253 0.20904174618294136 0.06597643654049962 0.16619738511579826 1.2801255206094642e-07 6.89274744423074 1.565189775819435 up HGDLPDIQIK(ub)HSSLITPLQAVAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGDLPDIQIKHSSLITPLQAVAQR 24 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 12330300.0 1582600.0 4290400.0 6457300.0 True False 2167729.988156883 4100835.941544489 4932218.732268004 1.0 1.8917651017187953 2.2752920147871523 21.047753635514653 -10.004492175392775 0.2044287099903455 3.8261911317887994e-20 2.603907157936514 0.9993885453044272 0.013210467362852349 1.5174390689365227 0.09369468485148494 1.0689178475712113 0.22379505818402023 9.897096951338148e-11 10.004492175392775 2.603907157936514 HGDLPDIQIK(ub)HSSLITPLQAVAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGDLPDIQIKHSSLITPLQAVAQR 24 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 23348200.0 6802800.0 9861500.0 6683900.0 True False 5656829.615138607 9808374.142145518 8081472.587138139 1.0 1.733899517831807 1.428622238419695 22.431562286691488 -10.121457103559237 4.642067733115986 0.9999595107627519 1.5812608779428392 0.8285862142158711 0.12462892755783461 86936806.52301726 4.225926689426311 45106.78035053437 0.04266379681929184 7.560367324442533e-11 10.121457103559237 0.5813013671800873 HGDLPDIQIK(ub)HSSLITPLQAVAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGDLPDIQIKHSSLITPLQAVAQR 24 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 85871000.0 13731000.0 10765000.0 61375000.0 True False 17775050.178474747 10165918.28680448 50205379.76068032 1.0 0.5719206519661597 2.8244859652479684 24.08335029675015 -6.857505290592234 1.1981995850901155 0.7690941173841781 2.9285202491897526 0.9505403843395385 0.2172205240915449 0.14939836549460248 0.4089850293676921 0.14152755975264117 0.3295110660482845 1.3883363970581585e-07 6.857505290592234 2.1594261318055743 up HGDPGDAAQQEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGDPGDAAQQEAK 13 0 O14737;O14737-2;K7ESJ4;Q3HM38;X6R2P6 O14737 PDCD5 Programmed cell death protein 5 0 23483900.0 1449700.0 11202100.0 10832100.0 False True 1900570.7389147684 9530790.345443804 9711298.200840218 1.0 5.014699085015859 5.109674689817332 20.85800129238371 -10.217947530240005 0.7820284695850623 2.1961904818488744e-21 5.090110892507387 0.9999301950428338 0.01600242334979172 1.531185405124892 0.4093541993294853 3.495962710266698 0.013851258467926621 6.054140140879366e-11 10.217947530240005 5.090110892507387 HGDPGDAAQQEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGDPGDAAQQEAK 13 0 O14737;O14737-2;K7ESJ4;Q3HM38;X6R2P6 O14737 PDCD5 Programmed cell death protein 5 0 12907930.0 4706400.0 2448530.0 5753000.0 False True 4556997.908153117 3426240.7979152715 4246116.713699465 1.0 0.7518635880401086 0.9317793861837327 22.119652277629935 -10.447351732035475 5.108233304451345 1.0002377339466242 0.8418214871119147 0.5075375806443142 0.07345031701959641 0.00019916185497281376 2.1546864606626725e-05 0.07122429603747062 0.023705987882543064 3.569836025428283e-11 10.447351732035475 -0.15841624683470945 HGDPGDAAQQEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGDPGDAAQQEAK 13 0 O14737;O14737-2;K7ESJ4;Q3HM38;X6R2P6 O14737 PDCD5 Programmed cell death protein 5 0 21138040.0 2133190.0 17422300.0 1582550.0 False True 3236205.1870786157 14313154.443948803 1269758.2988436932 1.0 4.422820438301553 0.3923602569804693 21.625871652059967 -6.68170025620718 1.8958047726132243 3.1623478327701395 0.40748204425554 0.3319311984794381 1.4501371027396672 0.43476268130728485 3.0225133427478412 0.6134438064609641 1.6144258671697351 2.0811325592388888e-07 6.68170025620718 -2.7548657885145995 HGDPGDAAQQEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGDPGDAAQQEAK 13 0 O14737;O14737-2;K7ESJ4;Q3HM38;X6R2P6 O14737 PDCD5 Programmed cell death protein 5 0 25685800.0 1449700.0 13556400.0 10679700.0 False True 1985693.266669424 12957433.422980059 8157374.815325684 1.0 6.525395256394954 4.108073967037183 20.921211353906603 -9.36672657235117 9.228567467505052 1.0000420615224714 5.3167346117161856 0.8095918810221163 0.9868672841814267 0.0 0.0 0.9555301247647934 0.3185100463342342 4.298069439363197e-10 9.36672657235117 4.316692550193714 HGDPGDAAQQEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGDPGDAAQQEAK 13 0 O14737;O14737-2;K7ESJ4;Q3HM38;X6R2P6 O14737 PDCD5 Programmed cell death protein 5 0 6396430.0 4706400.0 1201310.0 488720.0 False True 3913580.128871694 1194838.304588636 590909.0924140324 1.0 0.3053056958701173 0.15098939409844014 21.90005755306421 -13.999999999999888 0.2114085934228009 5.041107388598994 0.06132868356322471 0.9994908493327496 0.008332306945748252 12.780022594093232 0.14572458652537304 21.466648075443594 0.09051550662359922 1.0000000000002576e-14 13.999999999999888 -4.97977870503577 HGDPGDAAQQEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGDPGDAAQQEAK 13 0 O14737;O14737-2;K7ESJ4;Q3HM38;X6R2P6 O14737 PDCD5 Programmed cell death protein 5 0 5341780.0 2133190.0 1130310.0 2078280.0 False True 2761456.5064613293 1067407.2548776558 1700054.3649535908 1.0 0.38653777540225887 0.6156368427225845 21.396997974152416 -10.202345807668433 5.430606759480116 1.0000232422571946 0.5010873090623743 0.8634488342195963 0.0935293025806117 2.632065622256379e-05 3.86596049098254e-06 0.09056356913680827 0.030186452606392966 6.275584653981612e-11 10.202345807668433 -0.4989359331948203 HGDPGDAAQQEAK(ub)HR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGDPGDAAQQEAKHR 15 1 O14737;O14737-2;K7ESJ4 O14737 PDCD5 Programmed cell death protein 5 1 7244000.0 1910600.0 3456700.0 1876700.0 True False 2504815.1022767196 2940973.8341110693 1682517.0865775668 1.0 1.174128114860817 0.6717130877437877 21.25627268137796 -6.8131358945670675 1.4015907788302195 1.0945513874806596 0.6623026135030445 0.8677878757871602 0.07574126501620439 0.20255910139958552 0.7836892817246771 0.04248700267409953 0.09813605324348017 1.5376734134676178e-07 6.8131358945670675 -0.4322487739776151 HGDPGDAAQQEAK(ub)HR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGDPGDAAQQEAKHR 15 1 O14737;O14737-2;K7ESJ4 O14737 PDCD5 Programmed cell death protein 5 1 8201200.0 3168500.0 2819000.0 2213700.0 True False 3067917.7018492124 3944641.400890793 1633865.5604235192 1.0 1.2857715832837133 0.5325649900708528 21.54882835179784 -6.803904447035386 1.4400022260957575 1.1569005244816633 0.5211472373020961 0.8433102474629638 0.1228935366327838 0.21523243360151614 0.8806805869751164 0.06712758449111693 0.15575185959631618 1.5707083517355141e-07 6.803904447035386 -0.6357532871795671 HGDPGDAAQQEAK(ub)HR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGDPGDAAQQEAKHR 15 1 O14737;O14737-2;K7ESJ4 O14737 PDCD5 Programmed cell death protein 5 1 10650700.0 4365500.0 2801800.0 3483400.0 True False 6622782.660799886 2301796.899436682 2794904.463171544 1.0 0.34755736634103523 0.4220136166802703 22.659006083552413 -10.466693536260934 6.116606589207199 1.0003365121416907 0.38478549151370933 0.9891341016318379 0.030396636915342348 0.0001395617133361226 1.2168335306008996e-05 0.029446849557185625 0.009810472379486176 3.4143376238441644e-11 10.466693536260934 -0.6155510206279814 HGDPGDAAQQEAK(ub)HR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGDPGDAAQQEAKHR 15 1 O14737;O14737-2;K7ESJ4 O14737 PDCD5 Programmed cell death protein 5 1 6581200.0 1910600.0 2830400.0 1840200.0 True False 2617000.452023595 2705343.5691188527 1405582.660108646 1.0 1.0337573946641645 0.5370968350508993 21.319482742900853 -6.8906219314276775 1.0186595613763805 1.0262895179219718 0.4938493340852954 0.9812946693365773 0.03099024474404185 0.11864143475414778 0.21889386339363223 0.02316060652913997 0.057872603584652585 1.2864060341982268e-07 6.8906219314276775 -0.5324401838366764 HGDPGDAAQQEAK(ub)HR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGDPGDAAQQEAKHR 15 1 O14737;O14737-2;K7ESJ4 O14737 PDCD5 Programmed cell death protein 5 1 8733800.0 3168500.0 4049000.0 1516300.0 True False 2634748.138349896 4027187.233336429 1833351.3194209298 1.0 1.528490399032447 0.6958355118410411 21.329233627232117 -6.735216766230848 1.7043750071497497 1.3161794830620421 0.6958521171544494 0.5832377538210979 0.22208780275382828 0.32652547257777237 1.8605025936467903 0.10316910863938063 0.2544929348614438 1.839853459644168e-07 6.735216766230848 -0.6203273659075927 HGDPGDAAQQEAK(ub)HR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGDPGDAAQQEAKHR 15 1 O14737;O14737-2;K7ESJ4 O14737 PDCD5 Programmed cell death protein 5 1 13276900.0 4365500.0 4300100.0 4611300.0 True False 5651225.806869965 4060795.6549083088 3772090.7159336093 1.0 0.718568996123242 0.6674818605457301 22.430132405644862 -13.999999999999998 0.23998885501770775 2.862703434514966 0.6448914299648529 0.9995249418515797 0.003186641484982846 13.623017418931877 0.15504999897610447 12.160987039381414 0.024964709041488516 1.0000000000000041e-14 13.999999999999998 -2.217812004550113 HGEAQVK(ub)IWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGEAQVKIWR 10 1 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 1 7054500.0 2088200.0 2580000.0 2386300.0 True False 2021911.2340228916 3610207.454522263 1761256.4425345112 1.0 1.7855420128109287 0.871084948190446 20.947288230736206 -6.679358455611122 1.9040895520928331 1.49731829481529 0.8745846818831098 0.3211334194973071 0.3329805402741609 0.4400058825430125 3.08371371743123 0.14034819316445277 0.3704739348590062 2.092384741835639e-07 6.679358455611122 -0.6227336129321803 HGESAWNLENR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGESAWNLENR 11 0 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 28309340.0 2109000.0 14358700.0 11841640.0 False True 2764919.4235850503 12216437.929774215 10616380.685831694 1.0 4.418370324128338 3.839670912386402 21.39880600678665 -10.287668748495475 5.127672895215365 0.9993036833593639 4.1290206182580524 0.9749879244092113 0.23625304553846535 0.001880931174039523 0.0002612971968922291 0.2287861686794882 0.07625034257143018 5.156217772956879e-11 10.287668748495475 3.1297169348986884 HGESAWNLENR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGESAWNLENR 11 0 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 22338600.0 2400200.0 1831100.0 18107300.0 False True 2324006.964803057 2562267.7790603503 13364454.922643881 1.0 1.10252155775165 5.750608808427742 21.148182961677534 -6.911656904834584 0.8843617927450238 0.8635169831153879 6.373110927326848 0.9915322568281595 0.203888480740388 0.10333291595939763 0.1328944635661318 0.16830580502544737 0.47011946428410406 1.2255840354293712e-07 6.911656904834584 5.50959394421146 up HGESAWNLENR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGESAWNLENR 11 0 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 123563790.0 30074890.0 86464000.0 7024900.0 False True 45625806.89897235 71033823.65368451 5636425.435876944 1.0 1.5568781898142046 0.12353590695628654 25.443346737586943 -6.801345779631592 1.4503657867689521 1.306733387102418 0.10307609382796543 0.8360782053344293 0.23886996160879068 0.21884410979925917 0.9086961648596695 0.1295561269334248 0.30106238420556497 1.5799895711524237e-07 6.801345779631592 -1.2036572932744527 down HGESAWNLENR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGESAWNLENR 11 0 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 31049100.0 2109000.0 14065700.0 14874400.0 False True 2888754.293581994 13444230.864950176 11361373.06788395 1.0 4.653989055012227 3.932966224619986 21.46201606830954 -10.308003270722605 5.142437916155537 0.9990898678114217 4.293477639816628 0.9653013351064879 0.29435633789486765 0.003071972007723454 0.000413382230591806 0.2850543549203472 0.09500309954285736 4.920358300880373e-11 10.308003270722605 3.294387772005207 HGESAWNLENR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGESAWNLENR 11 0 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 5557600.0 2400200.0 1933600.0 1223800.0 False True 1995872.6468888826 1923183.3130104525 1479690.921788124 1.0 0.9635801743203724 0.7413754199671155 20.92858823711181 -6.935481572239273 0.7003336870411108 1.0027923766670677 0.6886602628308222 0.9975101924772389 0.0057035199883767535 0.08988971265662972 0.06445692085181548 0.005377545672806187 0.019535432377890277 1.160161442479008e-07 6.935481572239273 -0.3141321138362455 HGESAWNLENR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGESAWNLENR 11 0 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 43300690.0 30074890.0 6327800.0 6898000.0 False True 38932537.96971146 5975652.367416749 5642634.779456988 1.0 0.15348735733759913 0.1449336486577581 25.214473059679392 HGEVCPAGWKPGSDTIK(ub)PDVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGEVCPAGWKPGSDTIKPDVQK 22 2 Q06830;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 1 24403000.0 7557200.0 9368000.0 7477800.0 True False 9907562.384028915 7970330.916177987 6704068.988122621 1.0 0.8044694151031778 0.6766617991656195 23.240098715630054 -8.94013282889319 0.06558720426073446 1.7325782374754914 5.304184483082542e-10 0.9999935104983084 0.0003386696838413826 0.43016708905168216 0.020288674499566 0.2897950149323151 0.2372325216543175 1.1478025126036806e-09 8.94013282889319 -1.732578236945073 HGEVCPAGWKPGSDTIK(ub)PDVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGEVCPAGWKPGSDTIKPDVQK 22 2 Q06830;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 1 117091000.0 31024000.0 26537000.0 59530000.0 True False 47065676.1582077 21801265.015472665 47763869.4070741 1.0 0.4632094297804066 1.0148344463706307 25.488171985442676 -10.848621144699536 12.019280550076273 1.0039549324448904 0.7390219380755202 0.22984577901046843 0.22519997000005906 0.02394157340576071 0.0003015354480925245 0.21873511652919958 0.07268297778138655 1.4170293816590579e-11 10.848621144699536 -0.26493299436937023 HGEVCPAGWKPGSDTIK(ub)PDVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGEVCPAGWKPGSDTIKPDVQK 22 2 Q06830;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 1 24209300.0 7557200.0 9937100.0 6715000.0 True False 10351301.065650964 9498046.064404653 5129055.299766089 1.0 0.9175702652415654 0.4954986109703628 23.303308777152946 -6.939275824230264 0.6662659311869432 1.0048019314314491 0.38406354693567984 0.9980675099183257 0.009713983771148762 0.08809855393590167 0.05612569603003663 0.009404741412080317 0.036444303064479704 1.1500697375814797e-07 6.939275824230264 -0.6207383844957692 down HGEVCPAGWKPGSDTIK(ub)PDVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGEVCPAGWKPGSDTIKPDVQK 22 2 Q06830;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 1 18584200.0 8462300.0 4269400.0 5852500.0 True False 7036777.393453796 4246399.894790451 7076230.691097393 1.0 0.6034580401450258 1.0056067281139658 22.74648344379504 -10.925131578546834 10.752624541106675 1.0306226513649166 0.8045323841294962 0.2395456144886735 0.16417651437560524 0.08860847941785276 0.0006169625240729775 0.11686963570756274 0.05298774216792513 1.1881422005073561e-11 10.925131578546834 -0.22609026723542036 HGEVCPAGWKPGSDTIK(ub)PDVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGEVCPAGWKPGSDTIKPDVQK 22 2 Q06830;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 1 128972000.0 31024000.0 31607000.0 66341000.0 True False 40161179.57446658 29848042.665214006 54267618.716143295 1.0 0.7432063246516446 1.351245637980345 25.259298307535126 -6.792016480115075 1.4887340739109944 0.8568523245708489 1.35803336180852 0.8076440636105771 0.10930711636383213 0.23236486135060347 1.0174102126147209 0.057791445990042295 0.13508052650483393 1.6142972981388464e-07 6.792016480115075 0.5011810372376712 HGEVCPAGWKPGSDTIKPDVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGEVCPAGWKPGSDTIKPDVQK 22 2 Q06830;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 476143000.0 67423000.0 183830000.0 224890000.0 False True 88392205.92526075 156403280.56372756 201620540.09720734 1.0 1.7694238867165841 2.280976450205189 26.397415828299888 -8.272690115209068 0.13799249370751956 8.465402252730709e-15 3.3822364098088276 0.9999434457072416 0.003959237130644452 0.08937916704870548 0.02957008101352018 0.32824882921378534 0.33128309921537935 5.337155849907187e-09 8.272690115209068 3.382236409808819 HGEVCPAGWKPGSDTIKPDVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGEVCPAGWKPGSDTIKPDVQK 22 2 Q06830;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 184947000.0 70574000.0 31568000.0 82805000.0 False True 68333667.00025457 44173267.02494529 61115886.40324777 1.0 0.6464348975268769 0.8943744582450125 26.02609321267096 -10.138841845303451 5.485441418236239 1.0000043364108848 0.7704046778858954 0.5334371776762563 0.10122090180171357 5.368052823196453e-06 8.429303239316899e-07 0.09800856681343921 0.032668905580485935 7.263704277070204e-11 10.138841845303451 -0.22959965852498943 HGEVCPAGWKPGSDTIKPDVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGEVCPAGWKPGSDTIKPDVQK 22 2 Q06830;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 1276930000.0 157140000.0 984660000.0 135130000.0 False True 238392868.47281966 808939729.8163055 108421496.27041693 1.0 3.393305072414684 0.45480176049300985 27.828765837295 -6.690141692832649 1.8660131000201474 2.500261735702413 0.46497075911066915 0.3710467075723426 1.0121717618703965 0.4163626216174868 2.8110005649048033 0.4339250086688248 1.1297271309706771 2.0410719163024404e-07 6.690141692832649 -2.0352909765917437 HGEVCPAGWKPGSDTIKPDVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGEVCPAGWKPGSDTIKPDVQK 22 2 Q06830;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 444833000.0 67423000.0 200750000.0 176660000.0 False True 92351105.13806488 191880201.20852515 134936546.42690682 1.0 2.077725013920129 1.4611254107373888 26.46062588982278 -10.56450270117146 6.342166700974229 0.9986690291510923 1.7694252123286756 0.6749215327233216 0.2517257339000501 0.004743762273380604 0.00032573946730144853 0.24406141006599036 0.0812441312672278 2.7258207851505933e-11 10.56450270117146 0.7707561831775832 HGEVCPAGWKPGSDTIKPDVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGEVCPAGWKPGSDTIKPDVQK 22 2 Q06830;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 128163000.0 70574000.0 23980000.0 33609000.0 False True 58685407.95831018 23850814.98034266 40636486.509541616 1.0 0.4064181507826641 0.6924461790980404 25.806498488105237 -10.483532976785009 6.264161088508656 1.0002621365352735 0.5494321649403738 0.7679050863970788 0.11677045358450183 0.000427731906080047 3.526548752660815e-05 0.11312665837635127 0.037687501838488485 3.284483036676841e-11 10.483532976785009 -0.4508299715948997 HGEVCPAGWKPGSDTIKPDVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGEVCPAGWKPGSDTIKPDVQK 22 2 Q06830;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 439270000.0 157140000.0 128860000.0 153270000.0 False True 203420827.69248575 121688827.72295643 125376432.68300553 1.0 0.5982122337389917 0.6163401953734006 27.599892159387448 -10.479436576298022 9.426506784647563 1.0000048639887245 0.6072762145623798 0.9984045191271822 0.007400709346841923 7.565228477049497e-07 4.1781963758766325e-08 0.007165794611806128 0.002388568670870025 3.3156098693585685e-11 10.479436576298022 -0.39272864942634467 HGEVCPAGWKPGSETIIPDPAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGEVCPAGWKPGSETIIPDPAGK 23 1 Q13162 Q13162 PRDX4 Peroxiredoxin-4 0 6298600.0 1241100.0 5057500.0 0.0 False True 1627094.1188294978 4302940.713980589 0.0 1.0 2.6445555079973166 0.0 20.63386627506189 -6.739001278087903 1.6934084705220804 1.9801582946975131 0.00011824697663859045 0.5982889120322391 0.6910218106656201 0.3201011480350487 1.8025380800519115 0.3230523317753932 0.7926775521892473 1.8238903347736516e-07 6.739001278087903 -1.9800400477208746 HGEVCPAGWKPGSETIIPDPAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGEVCPAGWKPGSETIIPDPAGK 23 1 Q13162 Q13162 PRDX4 Peroxiredoxin-4 0 9403200.0 1241100.0 4746700.0 3415400.0 False True 1699968.2094663905 4536975.098762166 2608752.86237098 1.0 2.668858790121901 1.5345892045768617 20.697076336584782 -10.51511450488132 5.245392149842703 0.9968474771798456 2.1017239973493895 0.55711380726891 0.46306361922394573 0.01709563207694366 0.0015803237109433602 0.44898608069394264 0.149453140457402 3.054115767340674e-11 10.51511450488132 1.1048765201695439 HGFDPQSPLCVHIMLSGTVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGFDPQSPLCVHIMLSGTVTK 21 0 A0A3B3IRL2;O75629 A0A3B3IRL2 CREG1 Protein CREG1 0 116820600.0 28272600.0 55708000.0 32840000.0 False True 42891601.20392415 45766472.15140939 26349159.6057167 1.0 1.067026430974608 0.6143197937620015 25.35419183902953 -6.869247940681244 1.1381262999443176 1.0377374731587985 0.588190011338317 0.9639237479308954 0.03789162080073214 0.13757483170895435 0.33354256853461983 0.0258504974388943 0.06112084860192343 1.3513008791611173e-07 6.869247940681244 -0.44954746182048144 HGFDPQSPLCVHIMLSGTVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGFDPQSPLCVHIMLSGTVTK 21 0 A0A3B3IRL2;O75629 A0A3B3IRL2 CREG1 Protein CREG1 0 81673900.0 28272600.0 39444300.0 13957000.0 False True 36599438.0362643 37249190.030673616 11416969.210913464 1.0 1.0177530593165258 0.3119438391267385 25.125318161121978 -6.901130413976371 0.954088676488273 1.0284417249313946 0.2361313222156673 0.9871205052687981 0.03729405768704307 0.11057815999433172 0.17276197838542695 0.02925307799260818 0.07655282160237088 1.2556528479887798e-07 6.901130413976371 -0.7923104027157273 down HGFLILSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGFLILSR 8 0 Q10570 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 0 15333500.0 3292700.0 2529700.0 9511100.0 False True 3188175.0408328534 3539822.402211222 7019857.583116112 1.0 1.1102973823189164 2.201841960748272 21.604299409320383 -6.92636515468925 0.7760383407230619 0.980975702515219 2.406515173420442 0.9957746758409046 0.03525921175175292 0.09456898208187804 0.08724850568504056 0.03145396409897439 0.10081129302223188 1.1847721731258637e-07 6.92636515468925 1.4255394709052231 up HGFLILSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGFLILSR 8 0 Q10570 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 0 8804300.0 3292700.0 2839800.0 2671800.0 False True 2738025.941342811 2824501.433743831 3230461.026992575 1.0 1.0315831530648718 1.1798504090900828 21.38470468475466 -6.941220717217068 0.6481057568779519 0.9983644814637741 1.2213115668532275 0.9983194781416241 0.003214164344503002 0.08721406255452643 0.05210616154151156 0.0031584879259960734 0.012693996722902189 1.144930916570276e-07 6.941220717217068 0.2229470853894534 HGFSGIPITETGTMGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGFSGIPITETGTMGSK 17 0 A0A3B3IRL5;C9J029;H7C5T1;H7C511;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 10733300.0 1848300.0 3594900.0 5290100.0 False True 1789626.728208269 5030362.317155839 3904464.110401798 1.0 2.8108444279842177 2.181719823949463 20.771227277752466 -10.194134395753514 5.327983054902298 0.9999239016563438 2.496282125967196 0.882932788749814 0.25683904408718977 0.00023217911294439125 3.511710531864288e-05 0.24869576151501938 0.08289444503361316 6.39536895266971e-11 10.194134395753514 1.4963582243108524 HGFSGIPITETGTMGSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGFSGIPITETGTMGSK 17 0 A0A3B3IRL5;C9J029;H7C5T1;H7C511;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 6061500.0 1848300.0 2242900.0 1970300.0 False True 1536943.3435733353 2230817.0525192064 2382280.620362103 1.0 1.4514634269683884 1.5500119964236225 20.551632553186742 -11.900099196238301 0.25297350622240866 1.6505827553926338e-08 1.5926364204980845 0.9993668652685633 0.006025180801014843 4.917271913371867 0.1457932078271934 2.637987822041234 0.044635830993084345 1.2586378962728265e-12 11.900099196238301 1.592636403992257 HGGICDCQTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGGICDCQTSR 11 0 Q10713 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 6115700.0 999200.0 2665400.0 2451100.0 False True 1309960.876266565 2267732.7096478255 2197483.6846114285 1.0 1.7311453729144524 1.677518561374394 20.321092293713555 -10.473541152950034 4.713204607924843 0.9976747527676019 1.7043319671446078 0.99567101272157 0.021893054134890257 0.0005363461977267708 5.990917383254099e-05 0.02125414972156076 0.0070659528384141995 3.3609252002619315e-11 10.473541152950034 0.7066572143770059 HGGICDCQTSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGGICDCQTSR 11 0 Q10713 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 2833070.0 576940.0 1293400.0 962730.0 False True 875260.1599637811 1062582.6646196763 772445.9935204515 1.0 1.2140192290525902 0.88253302144178 19.739352377899262 -6.7324064624391635 1.7146383941185819 1.128449692809714 0.8826483503864443 0.5703291207736494 0.08995253332105888 0.3317337435436108 1.911789939666409 0.04155705946397698 0.10283408287871007 1.8517976880982425e-07 6.7324064624391635 -0.2458013424232698 HGGICDCQTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGGICDCQTSR 11 0 Q10713 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 7378900.0 999200.0 3203300.0 3176400.0 False True 1368631.24236469 3061767.6141034514 2426199.7400114723 1.0 2.237101944869678 1.7727198275990979 20.384302355236446 -10.268341457413538 5.151483256961331 0.9998289981466614 2.0049108862346308 0.861949232976823 0.18958320549855037 0.00037239755308393727 5.289164119508688e-05 0.18359361337824143 0.061187716467920275 5.390866072251685e-11 10.268341457413538 1.0050818880879695 HGGSLGLGLAAMGTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGGSLGLGLAAMGTAR 16 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 17631000.0 5142900.0 4982300.0 7505800.0 False True 6742391.70391445 4238960.260853286 6729171.816717588 1.0 0.6287027581610634 0.9980392881669592 22.684829013448336 -10.958809812219068 10.269825695878044 1.070463307675853 0.8133710231642106 0.2539814435590957 0.15078100698076222 0.08910549802047844 0.00035738377171398055 0.05347642084857741 0.04866436074673969 1.0994872253677914e-11 10.958809812219068 -0.25709228451164234 HGGSLGLGLAAMGTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGGSLGLGLAAMGTAR 16 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 9537000.0 2560600.0 1247700.0 5728700.0 False True 2479315.1546015753 1745913.116669544 4228181.6126838345 1.0 0.7041916851228667 1.705382877540351 21.24151023852295 -6.827563202120759 1.3386887136487808 0.8416494285378697 1.7310207163432203 0.9009207498861381 0.13219660894526045 0.18384223609012051 0.6451812110434716 0.07755223398892282 0.1785038547973485 1.4874308950963019e-07 6.827563202120759 0.8893712878053506 HGGSLGLGLAAMGTAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGGSLGLGLAAMGTAR 16 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 17764600.0 4839900.0 7490500.0 5434200.0 False True 7342482.144085533 6153761.751456384 4360127.988105524 1.0 0.8381037407647386 0.5938220757700672 22.807836421441127 -6.965159034675124 0.3553135639806284 1.0222094183011425 0.4014057388737143 0.999916383767817 0.0015266535302890822 0.0779070398287423 0.014669964823685046 0.0033105566741657294 0.020924769264799255 1.0835300625452754e-07 6.965159034675124 -0.6208036794274283 HGGSLGLGLAAMGTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGGSLGLGLAAMGTAR 16 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 16048900.0 5142900.0 4218800.0 6687200.0 False True 7044369.111646683 4032399.466294026 5107821.087207119 1.0 0.5724287586843128 0.7250927664710518 22.748039074971228 -10.090913611109102 5.630421400859886 1.0000026733976768 0.6487607625776137 0.875897176791236 0.062324820194540075 2.091535547285659e-06 3.377869523046815e-07 0.06034620709748281 0.02011524922236695 8.111223884661895e-11 10.090913611109102 -0.35124191082006306 HGGSLGLGLAAMGTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGGSLGLGLAAMGTAR 16 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 9071300.0 2560600.0 2826600.0 3684100.0 False True 2129252.35381371 2811372.544763828 4454428.276646208 1.0 1.3203566687285189 2.0920151942853877 21.021915513957225 -6.956253762733307 0.48536237087256473 0.9823810752219669 2.462456266539345 0.9996050257232794 0.009108793917992674 0.08106756633008146 0.02629040803480066 0.011001250787208792 0.06364648206373694 1.1059773611911268e-07 6.956253762733307 1.4800751913173777 up HGGSLGLGLAAMGTAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGGSLGLGLAAMGTAR 16 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 21287500.0 4839900.0 12125000.0 4322600.0 False True 6265345.9586920105 11450233.091268387 3535931.1536214557 1.0 1.8275500134806288 0.5643632733027303 22.578962743533577 -6.729961058469582 1.7232970029552004 1.498045878695282 0.5651176231164952 0.5590679067106645 0.34788512246826153 0.33633768832672206 1.956789000968617 0.15997336241313853 0.39699192975494846 1.862254110402927e-07 6.729961058469582 -0.9329282555787868 HGGTLSDLGK(ub)QVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGGTLSDLGKQVR 13 1 Q8N511 Q8N511 TMEM199 Transmembrane protein 199 1 7817300.0 1964500.0 1680100.0 4172700.0 True False 2575478.5242450614 1429435.628978507 3740949.0313647385 1.0 0.5550174911272114 1.4525258106981522 21.296409079451646 -6.7719325594454025 1.567424883848307 0.7453965979106153 1.4579018260951375 0.7377636900508164 0.18763522968908478 0.2633184138647066 1.277052380847582 0.0943498004239413 0.22416205226334426 1.6907034565678932e-07 6.7719325594454025 0.7125052281845222 HGGTLSDLGK(ub)QVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGGTLSDLGKQVR 13 1 Q8N511 Q8N511 TMEM199 Transmembrane protein 199 1 13102200.0 2471700.0 4856800.0 5773700.0 True False 3749749.6054745363 3990066.0936484006 4632525.664297387 1.0 1.064088676167339 1.2354226686320657 21.838362830265726 -6.954009146061834 0.5129449299862707 0.9969215538328068 1.3101443224944265 0.9994795071383034 0.0022672671663739228 0.08191469076593029 0.0296005260815659 0.0025983667393446896 0.014143573441652988 1.111708314918602e-07 6.954009146061834 0.3132227686616197 HGGTLSDLGK(ub)QVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGGTLSDLGKQVR 13 1 Q8N511 Q8N511 TMEM199 Transmembrane protein 199 1 7601300.0 1964500.0 1380700.0 4256100.0 True False 2690828.738616325 1319696.1086356682 3250896.837130968 1.0 0.49044225286306437 1.2081396301730598 21.359619140974537 -6.716013926494033 1.7737112273955076 0.6886810465895442 1.206775646785781 0.4936486683644513 0.21453467453349406 0.36310519267420605 2.2302893919920406 0.09612191845365334 0.24243579225994502 1.9230300622365057e-07 6.716013926494033 0.5180946001962369 HGGTLSDLGK(ub)QVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGGTLSDLGKQVR 13 1 Q8N511 Q8N511 TMEM199 Transmembrane protein 199 1 13304500.0 2471700.0 5645200.0 5187600.0 True False 3199664.3744910094 5331039.657470374 4243510.029270961 1.0 1.6661246410628352 1.3262359837181368 21.609489152358176 -10.103438690939639 4.395324579343944 0.9999534119523629 1.496180312193846 0.7396835940885057 0.13875896355139816 48310557.61578014 3.0081134036726604 27810.015101866233 0.047500883958317607 7.880636740187664e-11 10.103438690939639 0.4962269002414831 HGGVIHIYVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGGVIHIYVDK 11 0 Q14498-3;Q14498-2;Q14498;H0Y4X3 Q14498-3 RBM39 RNA-binding protein 39 0 36043000.0 12905000.0 10446000.0 12692000.0 False True 16918579.972197782 8887497.51818909 11378753.5902608 1.0 0.5253098979225129 0.6725596125064544 24.012105147974292 -10.865218822972471 10.962193180744789 1.0133572707495146 0.5989347552144875 0.9081848427325104 0.06011444425018584 0.01820893448491093 0.0002238801301661997 0.05400734615734302 0.019401853453957004 1.3638957529435185e-11 10.865218822972471 -0.4144225155350272 HGGVIHIYVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGGVIHIYVDK 11 0 Q14498-3;Q14498-2;Q14498;H0Y4X3 Q14498-3 RBM39 RNA-binding protein 39 0 37458900.0 9503700.0 6358200.0 21597000.0 False True 9202010.245562363 8897062.417574985 15940097.803887935 1.0 0.9668607380507495 1.732240823310862 23.133517632069807 -6.8967789402024575 0.9813939641196647 0.9653040900176199 1.8075288702079146 0.98489444616851 0.043416289690811204 0.11381673690868101 0.19108869591534608 0.03336986785395285 0.0855023523003832 1.268297276305365e-07 6.8967789402024575 0.8422247801902948 HGGVIHIYVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGGVIHIYVDK 11 0 Q14498-3;Q14498-2;Q14498;H0Y4X3 Q14498-3 RBM39 RNA-binding protein 39 0 31309600.0 12905000.0 9282900.0 9121700.0 False True 17676327.244511936 8872750.78355475 6967342.327308471 1.0 0.5019566938776561 0.39416232970407694 24.075315209497184 -13.999999999999998 0.2150852999980897 3.9422802907355545 0.3337155666504194 0.9994934683552643 0.005939006114104017 12.87058055040198 0.14695882798078574 16.043438466281227 0.061651011020595656 1.0000000000000041e-14 13.999999999999998 -3.6085647240851353 HGGVIHIYVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGGVIHIYVDK 11 0 Q14498-3;Q14498-2;Q14498;H0Y4X3 Q14498-3 RBM39 RNA-binding protein 39 0 14172300.0 9503700.0 0.0 4668600.0 False True 7902747.635296163 0.0 5644782.674832519 1.0 0.0 0.7142810241872256 22.913922907504084 -10.591682831428407 8.756684672397645 1.0001708485769574 0.3571405141055784 0.5192358685797545 0.29160400703521205 0.0009728744071736759 4.53643321068709e-05 0.28241604333870346 0.09411478857789392 2.5604551241638845e-11 10.591682831428407 -0.643030334471379 HGGYK(ub)PSDEHKTDLNPDNLQGGDDLDPNYVLSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGGYKPSDEHKTDLNPDNLQGGDDLDPNYVLSSR 34 2 P12277;G3V4N7;G3V461 P12277 CKB Creatine kinase B-type 1 19166400.0 4705800.0 5373300.0 9087300.0 True False 4556416.95482469 7518886.7113893265 6707063.516843593 1.0 1.6501752991301075 1.472003897655071 22.11946834251897 -10.05112129373917 4.430448981392058 0.9999658905045326 1.561089598447446 0.9296909200735104 0.07273817025122177 10685209.757349782 8080321.2951189475 3204.661401156025 0.024900210383705827 8.889528083052032e-11 10.05112129373917 0.5611237079429134 HGGYK(ub)PSDEHKTDLNPDNLQGGDDLDPNYVLSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGGYKPSDEHKTDLNPDNLQGGDDLDPNYVLSSR 34 2 P12277;G3V4N7;G3V461 P12277 CKB Creatine kinase B-type 1 16659300.0 3275700.0 8565200.0 4818400.0 True False 4486814.812463988 8186761.142671277 3680393.158062983 1.0 1.824626485570377 0.8202685673228959 22.09726020917679 -6.6885064257871365 1.8715141149581738 1.5177006754318172 0.8237798069225631 0.3635535955534519 0.34886390388594385 0.41987777084546324 2.850097893107527 0.1491815240498638 0.38924193635529847 2.048771736267114e-07 6.6885064257871365 -0.693920868509254 HGGYK(ub)PSDEHKTDLNPDNLQGGDDLDPNYVLSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGGYKPSDEHKTDLNPDNLQGGDDLDPNYVLSSR 34 2 P12277;G3V4N7;G3V461 P12277 CKB Creatine kinase B-type 1 12886700.0 4705800.0 5347600.0 2833300.0 True False 3913081.202287185 5318791.417384502 3425729.9303009384 1.0 1.3592335917475167 0.8754558756150036 21.899873617953247 -6.707874234522561 1.8029512521857554 1.2213326155853819 0.8766717761503089 0.4548812834265584 0.15143111072213686 0.3793864580033718 2.402695890350718 0.06687514964043789 0.17032295628681776 1.9594120090807033e-07 6.707874234522561 -0.344660839435073 HGGYK(ub)PSDEHKTDLNPDNLQGGDDLDPNYVLSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGGYKPSDEHKTDLNPDNLQGGDDLDPNYVLSSR 34 2 P12277;G3V4N7;G3V461 P12277 CKB Creatine kinase B-type 1 66663000.0 16341000.0 29029000.0 21293000.0 True False 21153746.62926633 27413510.631458193 17417892.484629966 1.0 1.2959175086994492 0.8233951549997395 24.334409871989934 -6.737413411993844 1.696432117032519 1.1765967824447772 0.823285435269738 0.5931781576247812 0.12434129903287096 0.32250731469460164 1.8214277681776885 0.0580117661548056 0.14274725249300851 1.8305710423238786e-07 6.737413411993844 -0.3533113471750392 HGIEYQEK(ub)PLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGIEYQEKPLLR 12 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 64444200.0 8258200.0 12098000.0 44088000.0 True False 10826580.172522556 10293025.557634652 39526196.6819586 1.0 0.9507180839761344 3.6508478256388446 23.368074270289526 -6.902742942113887 0.9437517094256805 0.8960301186709994 3.9506173721019118 0.9878825746054885 0.13885365123151056 0.10941473948367005 0.16624633546542666 0.10975093480605963 0.28969490683295884 1.2509992746607125e-07 6.902742942113887 3.0545872534309124 up HGIEYQEK(ub)PLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGIEYQEKPLLR 12 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 128576700.0 8143700.0 14403000.0 106030000.0 True False 7885182.701136 20154193.01065278 78257562.16818254 1.0 2.555957645439111 9.924635247437976 22.910712752237135 -6.9410233670838375 0.6499738880595709 0.9185276886921598 11.973014956606361 0.9982948849383014 0.1607352294179265 0.08730287124915055 0.05250688997881689 0.15770451321378737 0.6314025392142307 1.1454513091246917e-07 6.9410233670838375 11.054487267914201 HGIEYQEK(ub)PLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGIEYQEKPLLR 12 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 262361000.0 11661000.0 112670000.0 138030000.0 True False 17690589.53329229 92563158.20527208 110748309.99930188 1.0 5.23233881104276 6.260295045051061 24.076478790396237 -9.397056190656476 0.4457475357961261 4.873257030673736e-21 6.328549886735258 0.9980856526191563 0.09960217168271467 0.7473620868746789 0.18349659653766184 1.5220349339879127 0.23154058457456642 4.008148553360648e-10 9.397056190656476 6.328549886735258 HGIEYQEK(ub)PLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGIEYQEKPLLR 12 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 66505200.0 8258200.0 6830000.0 51417000.0 True False 11311479.709463645 6528228.016210342 39273363.56635491 1.0 0.5771329820579142 3.4719916911929047 23.431284331812417 -6.8697967005508795 1.1352436445696414 0.7611585597554964 3.6408219691915544 0.9644761212505214 0.2406304224669463 0.1370460994774939 0.33024573790364553 0.16452781617178738 0.38936877361480055 1.3495944992043222e-07 6.8697967005508795 2.8796634094360583 up HGIEYQEK(ub)PLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGIEYQEKPLLR 12 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 82775700.0 8143700.0 17412000.0 57220000.0 True False 6771847.377080648 17318198.0999886 69184437.44461225 1.0 2.5573816324629712 10.216479136663258 22.69111802767141 -6.940175291596554 0.6579323033635878 0.9142808085459266 12.292577296516395 0.9981867476632915 0.17152599652410266 0.08768680531703593 0.05424651114729207 0.16718999055780684 0.6586959530680816 1.1476902928610233e-07 6.940175291596554 11.378296487970468 HGIEYQEK(ub)PLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGIEYQEKPLLR 12 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 213948000.0 11661000.0 103260000.0 99027000.0 True False 15095394.372674536 97513490.2271649 81005102.10282499 1.0 6.459817333668499 5.366213038425763 23.847605112488687 -10.096828798960175 5.818390129761116 0.9999726902975071 5.913015186047487 0.9641706147882245 0.4464620839780498 0.00015817676120167428 2.4551354846582157e-05 0.43228739098753843 0.1440950179964857 8.001496157936046e-11 10.096828798960175 4.9130424957499805 HGIEYQEKPLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGIEYQEKPLLR 12 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 0 3422410.0 640510.0 1240000.0 1541900.0 False True 839714.8127076639 1054996.833482142 1382358.9789491901 1.0 1.2563751615626506 1.646224358591184 19.67953991167151 -6.9650295257665205 0.35754875199022107 0.9654518432647413 1.950456560496307 0.9999137482244421 0.0024674971523982567 0.07795097929275666 0.014824862510482728 0.0052572749642797395 0.03334752201929179 1.0838532251155205e-07 6.9650295257665205 0.9850047172315656 HGINCFINR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGINCFINR 9 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 81269570.0 19942240.0 36456030.0 24871300.0 False True 26144469.76092686 31016932.42849197 22297856.458355933 1.0 1.186366857393568 0.8528708618784182 24.640002475224804 -6.755015795599844 1.6309361865561454 1.1089176163867673 0.8519309316321756 0.6704311991021819 0.07834074899410924 0.291362066762267 1.5261805462320235 0.037919293739736896 0.09159083421765313 1.75785967818662e-07 6.755015795599844 -0.25698668475459174 HGINCFINR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGINCFINR 9 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 32766670.0 20565570.0 6531700.0 5669400.0 False True 19912727.237373885 9139841.87236553 4184414.061645704 1.0 0.45899498162216096 0.21013766782241877 24.247187489608667 -9.747788148766885 0.20785212441094575 1.5484891889756411 1.2082174987715205e-15 0.9993951307400266 0.008109415676251874 1.19380422792315 0.0887905343450105 0.5280638435578793 0.13735250550199957 1.7873592458868823e-10 9.747788148766885 -1.54848918897564 HGINCFINR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGINCFINR 9 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 222819300.0 66703800.0 99216100.0 56899400.0 False True 101194541.3009881 81510211.77607253 45653208.650107004 1.0 0.805480322635512 0.4511429970744996 26.592556228475036 -6.961830167953574 0.4088246458054818 1.0176802353315122 0.22581842915370937 0.9998321664047348 0.002943568769157439 0.07905372975216907 0.018762676652855952 0.004561388086965738 0.029595861450739544 1.0918672306447723e-07 6.961830167953574 -0.7918618061778029 down HGINCFINR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGINCFINR 9 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 67752170.0 19942240.0 22061830.0 25748100.0 False True 27315425.04677221 21087065.401884276 19666929.07876506 1.0 0.7719837917871272 0.7199935217954461 24.703212536747696 -13.999999999999998 0.20771556722533807 2.3064749316983297 0.688684450175537 0.9994888546829701 0.002749386259773659 12.694124545169082 0.1444710841059903 6.761058540129001 0.031296725936986784 1.0000000000000041e-14 13.999999999999998 -1.6177904815227926 HGINCFINR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGINCFINR 9 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 41140370.0 20565570.0 9182800.0 11392000.0 False True 17101182.664227396 9133330.433756905 13774014.52934329 1.0 0.5340759532884349 0.8054422199790928 24.027592765042943 -10.230860873336702 5.66299656257384 1.0000145612495996 0.6697590866337556 0.6638252972939552 0.11078481446605318 2.0367909119322046e-05 2.76633036520541e-06 0.10727166124376417 0.03575564511997065 5.876775854688492e-11 10.230860873336702 -0.33025547461584404 HGINCFINR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGINCFINR 9 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 168754500.0 66703800.0 48900000.0 53150700.0 False True 86349384.02847163 46178672.01344532 43477817.97223611 1.0 0.5347886673773956 0.5035104588343137 26.363682550567486 -13.999999999999998 0.3835392050961476 8.058955069352558 0.5009310734040989 0.9998131614149425 0.003103303817771446 24.48779475319452 0.20231623158610618 142.93272663603506 0.008388532637136068 1.0000000000000041e-14 13.999999999999998 -7.558023995948459 HGIPMSHVAR ddPTM_RPMI8226_Bortezomib_1h_R1 2 HGIPMSHVAR 10 0 G5E9R5;P24666-4;P24666 G5E9R5 ACP1 Low molecular weight phosphotyrosine protein phosphatase 0 15130750.0 3738250.0 6335000.0 5057500.0 False True 4900881.95126449 5389842.693636596 4534198.4149656445 1.0 1.0997699490080448 0.9251800920843978 22.22460996594403 -6.751732407922112 1.6437209100298424 1.0585433017630392 0.9247925001956193 0.6563085477218557 0.04192769167059659 0.2970164454727963 1.5794539251255755 0.020146922211269132 0.04881712147920489 1.7711999532754557e-07 6.751732407922112 -0.13375080156741992 HGIPMSHVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGIPMSHVAR 10 0 G5E9R5;P24666-4;P24666 G5E9R5 ACP1 Low molecular weight phosphotyrosine protein phosphatase 0 7496100.0 1814800.0 2285900.0 3395400.0 False True 1757190.1673712982 3198671.790811018 2506042.8801834118 1.0 1.8203333083727253 1.426164866340206 20.744838901067375 -10.347097559561133 5.514265154193537 0.9998435470937332 1.6232490873564698 0.7692387770759801 0.1609185926146093 0.00030959019978084816 3.6656390913262483e-05 0.15584724666233038 0.051936252440955566 4.496788280582098e-11 10.347097559561133 0.6234055402627365 HGIPMSHVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGIPMSHVAR 10 0 G5E9R5;P24666-4;P24666 G5E9R5 ACP1 Low molecular weight phosphotyrosine protein phosphatase 0 22599300.0 6461100.0 11316000.0 4822200.0 False True 9801961.069681395 9296571.387688462 3869090.056354653 1.0 0.9484399419258905 0.3947261194825797 23.224638986150488 -6.925058606730102 0.7862936806067483 1.0101376398549118 0.294145743948289 0.9954747285153246 0.018431060891316103 0.0952860032648119 0.0908532946743087 0.016321752033404472 0.051529645219511276 1.1883418534682755e-07 6.925058606730102 -0.7159918959066227 down HGIPMSHVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 HGIPMSHVAR 10 0 G5E9R5;P24666-4;P24666 G5E9R5 ACP1 Low molecular weight phosphotyrosine protein phosphatase 0 15660750.0 3738250.0 5506000.0 6416500.0 False True 5120382.047407721 5262726.714092848 4901054.85196562 1.0 1.0277996183423834 0.9571658533657388 22.28782002746692 -6.799953744810131 1.4562570000512878 1.0153390971376879 0.956193618401887 0.8319879319032789 0.011908628925180008 0.22082247574498992 0.9245588597490064 0.006433491747964248 0.014961312735197307 1.5850620028943655e-07 6.799953744810131 -0.059145478735800894 HGIPMSHVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 HGIPMSHVAR 10 0 G5E9R5;P24666-4;P24666 G5E9R5 ACP1 Low molecular weight phosphotyrosine protein phosphatase 0 9106860.0 2445720.0 4403540.0 2257600.0 False True 2033724.5437668029 4379817.255985747 2729653.722036992 1.0 2.1535941381095705 1.342194413891082 20.955692857048042 -10.187537309404416 4.863328167181483 0.9999163304330116 1.7478942760023595 0.5311306061215189 0.331252550302064 0.0003005455651580671 5.020871098616678e-05 0.3207694957173952 0.10691130089138637 6.493258468442848e-11 10.187537309404416 0.7479779455693478 HGIPMSHVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGIPMSHVAR 10 0 G5E9R5;P24666-4;P24666 G5E9R5 ACP1 Low molecular weight phosphotyrosine protein phosphatase 0 20739600.0 6461100.0 7290500.0 6988000.0 False True 8364021.317321618 6884777.266135446 5716255.702934972 1.0 0.8231420037006953 0.683433899325052 22.995765308242937 -6.973780001681526 0.1411954356768045 1.1839450458714353 0.318983215442495 0.9999988819801433 0.00013684278167412926 0.0750940567949357 0.004280506150480608 0.00779895116486333 0.01809675407692949 1.0622335110906816e-07 6.973780001681526 -0.8649618304289404 HGIPTAQWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGIPTAQWK 9 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 40840000.0 12421000.0 15358000.0 13061000.0 False True 16284051.285135103 13066646.265015135 11709573.009958757 1.0 0.802419866912543 0.7190822974530816 23.95695633444577 -13.999999999999956 0.11815346261063762 1.9431312128272151 0.5826998549716248 0.9997020468676502 0.0020334260994051816 11.971176543274238 0.10554432215181718 2.6578139050491445 0.121015552858397 1.0000000000001022e-14 13.999999999999956 -1.3604313578555902 HGIPTAQWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGIPTAQWK 9 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 32165100.0 7368500.0 8722600.0 16074000.0 False True 7134591.000812973 12205579.667758087 11863737.19033638 1.0 1.7107609485066886 1.6628475534175022 22.766399297131517 -10.253291708675514 4.796384939737301 0.9998199751027772 1.6868042509633643 0.9963631373904248 0.01956056163984728 3.7665301246429575e-05 5.863841865548737e-06 0.018944320150884715 0.006313144122178764 5.580952051672449e-11 10.253291708675514 0.6869842758605871 HGIPTAQWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGIPTAQWK 9 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 99350000.0 33656000.0 42289000.0 23405000.0 False True 51058612.58318194 34742197.544534914 18778991.491224084 1.0 0.6804375557196114 0.3677928275201439 25.60565100010467 -7.208181012986377 0.24986166116760244 1.1126559255512318 2.2561789708664387e-12 0.9999646675421671 0.0015341799731526642 0.09168400096072223 0.012850059093946094 0.011804699063049685 0.03934199927360662 6.191829471942428e-08 7.208181012986377 -1.1126559255489756 down HGIPTAQWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGIPTAQWK 9 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 46786000.0 12421000.0 15015000.0 19350000.0 False True 17013379.36490373 14351587.652034868 14779928.525759319 1.0 0.8435471486423342 0.8687238560170054 24.020166395968662 -10.517151082359463 9.10366277238955 1.0000057844213028 0.8561355023389572 0.9775462283345823 0.010278347745218474 1.2067514999749434e-06 6.399920460244956e-08 0.009952367455285483 0.00331732247031331 3.0398273466112215e-11 10.517151082359463 -0.14387028208234565 HGIPTAQWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGIPTAQWK 9 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 29651600.0 7368500.0 12800000.0 9483100.0 False True 6127234.229897805 12731043.859398931 11465972.365099661 1.0 2.077779856575072 1.8713128852087153 22.546804572565794 -10.158402940292055 5.012117581348168 0.9999410317515485 1.9745463708936366 0.9674329589284142 0.08428978810361398 5.554477710853029e-05 9.326686798768351e-06 0.08161813533730432 0.027204412130855136 6.94379770084699e-11 10.158402940292055 0.9746053391420881 HGIPTAQWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGIPTAQWK 9 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 80578000.0 33656000.0 23191000.0 23731000.0 False True 43568355.45894294 21900400.463472597 19412201.50062246 1.0 0.50266759515655 0.4455573614412812 25.37677732219712 -13.999999999999998 0.3054617609034827 5.681912380645131 0.4322848699581428 0.9996619782052484 0.004577948079600589 16.95302907893843 0.17569511653100173 50.32121730316336 0.02016635237192623 1.0000000000000041e-14 13.999999999999998 -5.249627510686988 HGK(ub)APILIATDVASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGKAPILIATDVASR 15 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 9152100.0 2225700.0 4892600.0 2033800.0 True False 2917914.2537094597 4162643.15120543 1823361.8855871747 1.0 1.4265817255985445 0.6248853554449681 21.476506057937847 -6.762137496164189 1.6042678028219641 1.2471223691537168 0.6216269478093979 0.6996863604974513 0.1794815985319853 0.2793441190832555 1.4173984029352 0.08824947890063417 0.21164549585619963 1.7292687918895593e-07 6.762137496164189 -0.6254954213443189 HGK(ub)APILIATDVASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGKAPILIATDVASR 15 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 12813400.0 2821700.0 4078900.0 5912800.0 True False 2732126.6780204875 5707626.041182494 4364060.299802223 1.0 2.089078111604199 1.5973125751856145 21.38159294662531 -10.400286427215796 5.390620914782559 0.9995067130072411 1.843195343394918 0.7967453159261477 0.2007624395519713 0.0011908587221435506 0.0001324844167484997 0.19449373851727564 0.06479579874405746 3.9784469626662815e-11 10.400286427215796 0.8436886303876768 HGK(ub)APILIATDVASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGKAPILIATDVASR 15 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 9318300.0 2225700.0 2630700.0 4461900.0 True False 3048601.437280914 2514466.9754384374 3408091.1157150194 1.0 0.8247936068944198 1.1179195397725519 21.53971611946074 -6.744774824387513 1.6688680795291686 0.8963380052683562 1.1182896496776653 0.626369208448571 0.07361174437701058 0.3092226735911541 1.692662061504537 0.034867387492587186 0.0851286178430219 1.7998038463645875e-07 6.744774824387513 0.22195164440930915 HGK(ub)APILIATDVASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGKAPILIATDVASR 15 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 9575100.0 2821700.0 3733400.0 3020000.0 True False 2346368.572504937 3713287.4331781236 3651468.0370976725 1.0 1.5825678355442216 1.556220996089901 21.161998222059587 -10.057580710558456 4.829859478552073 0.99998450256233 1.569394415774101 0.9983967723207617 0.010756052196830627 7455696.375856549 0.18416348192595258 1325.2556034776323 0.0036820827565604668 8.758289358931389e-11 10.057580710558456 0.5694099132117711 HGK(ub)PTDSTPATWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGKPTDSTPATWK 13 1 O60832;O60832-2;H7C2Q2 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 2643040.0 740240.0 1141000.0 761800.0 True False 970461.8084943562 970767.2475831658 682976.2437015987 1.0 1.0003147358156046 0.7037641643633734 19.88831191274416 -6.906656986679125 0.918208143994773 1.0101804823824605 0.6680599202494889 0.9895974636602551 0.014250554161995829 0.10667014380020726 0.151069228936229 0.011477605716188005 0.030995119396101188 1.239775396068608e-07 6.906656986679125 -0.3421205621329716 HGK(ub)PTDSTPATWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGKPTDSTPATWK 13 1 O60832;O60832-2;H7C2Q2 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 2832180.0 740240.0 746740.0 1345200.0 True False 1013926.7322338239 713746.557661041 1027491.4652636421 1.0 0.7039429329262841 1.0133784154205434 19.951521974267052 -11.045856027445101 11.65694029427723 1.483953904642123 0.8586606741655358 0.21763704506635861 0.126326506737142 0.04276774689378379 0.00016823980809695002 0.003292400432569566 0.04077170473145916 8.997958225586708e-12 11.045856027445101 -0.6252932304765872 HGK(ub)YMACCLLYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGKYMACCLLYR 12 1 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 78647000.0 21755000.0 44091000.0 12801000.0 True False 28521015.67571966 37512794.66537195 11476475.315862646 1.0 1.3152685406399154 0.40238662768355515 24.76552202342085 -6.813447976187797 1.399966850893218 1.1711303885764366 0.38512017905817775 0.8686515243384044 0.13720422891998238 0.2021314605050261 0.7801094500359751 0.0770475351521895 0.1779668610185745 1.5365688467441432e-07 6.813447976187797 -0.7860102095182588 down HGK(ub)YMACCLLYR ddPTM_RPMI8226_Bortezomib_8h_R1 2 HGKYMACCLLYR 12 1 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 282431500.0 57661400.0 47705100.0 177065000.0 True False 87476559.41299888 39191752.18335245 142068025.13965353 1.0 0.44802576194518934 1.624069648977786 26.38239314230881 -6.779075522645985 1.5394800463843108 0.6870845677001454 1.6331168545102706 0.7641079273534942 0.23333314067456237 0.2520104121125968 1.1796527425555636 0.11938488955351786 0.28191580582646164 1.6631234125197373e-07 6.779075522645985 0.9460322868101252 HGK(ub)YMACCLLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 HGKYMACCLLYR 12 1 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 97639200.0 26510700.0 49302100.0 21826400.0 True False 36312422.21472938 47123770.20175749 16671453.848818261 1.0 1.2977313912879849 0.459111588597244 25.113959832317843 -6.810731876223043 1.4113965450893786 1.1621263865645406 0.44418756072297494 0.8617232731407686 0.12908196003678188 0.20581863289852842 0.8079250037716462 0.07190856962779711 0.16628932917222103 1.5462087398947436e-07 6.810731876223043 -0.7179388258415657 down HGK(ub)YMACCLLYR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 HGKYMACCLLYR 12 1 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 223157200.0 57661400.0 61614800.0 103881000.0 True False 74643818.97612001 58185882.21623779 84975723.90907088 1.0 0.7795137362258029 1.138416081527879 26.15351946440126 -6.740473404531388 1.6848310457736289 0.8688837367003803 1.13865349088243 0.6071067051955723 0.09263822922821893 0.31696835763495096 1.766850406212799 0.04349308917781415 0.10667816472828807 1.8177183667236293e-07 6.740473404531388 0.2697697541820496 HGLEETAAK(ub)CK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGLEETAAKCK 11 1 D6RCD0;Q8NBQ5 D6RCD0 HSD17B11 Estradiol 17-beta-dehydrogenase 11 1 7922830.0 563630.0 2035400.0 5323800.0 True False 855067.916872441 1672166.9673472128 4271548.596495566 1.0 1.9555954963945474 4.9955664482413225 19.705679490275838 -6.950124960347546 0.5574695114225259 0.959702122944842 6.136115386206661 0.999211057298455 0.047849883907086305 0.08343559600761052 0.03575492319189418 0.05145053466281174 0.2525673466617971 1.121695660316194e-07 6.950124960347546 5.176413263261819 HGLEETAAK(ub)CK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGLEETAAKCK 11 1 D6RCD0;Q8NBQ5 D6RCD0 HSD17B11 Estradiol 17-beta-dehydrogenase 11 1 3816230.0 563630.0 1330200.0 1922400.0 True False 729630.1458082969 1256173.2006602243 1572542.9254897225 1.0 1.7216574834207459 2.1552603528293535 19.476805812368287 -9.008177474152477 0.1441588403457028 2.836621163131224e-08 2.940854254687352 0.999859841947177 0.005641143630678608 0.4857347320208429 0.04733542866380981 0.5514753923276978 0.3443205592791425 9.813468343350797e-10 9.008177474152477 2.9408542263211404 HGLEVIYMIEPIDEYCVQQLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 HGLEVIYMIEPIDEYCVQQLK 21 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 142152900.0 26162800.0 82440100.0 33550000.0 False True 39690880.35688357 67728020.04755883 26918827.794512585 1.0 1.7063874481638397 0.6782119104557495 25.242304226358417 -6.721825577797843 1.7527126941861655 1.428927863852475 0.6796512379013193 0.5210605537865047 0.29718759107813875 0.3518212947907335 2.113184972257864 0.13457942235103143 0.3371257160152266 1.897467832955651e-07 6.721825577797843 -0.7492766259511556 HGLEVIYMIEPIDEYCVQQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGLEVIYMIEPIDEYCVQQLK 21 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 63698000.0 17352000.0 22527000.0 23819000.0 False True 22462506.05905569 21273352.64717551 19484186.40357871 1.0 0.9470605190376442 0.8674092887210918 24.421015557100606 -6.9652068083834235 0.3544887176857015 1.0073104860275373 0.8044529833886629 0.9999173299652939 0.0004954502884493242 0.07789088307081929 0.014613129169563099 0.0010814909256126799 0.006826344375296989 1.0834108775123287e-07 6.9652068083834235 -0.20285750263887437 HGLINFGIYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGLINFGIYK 10 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 38172700.0 9253700.0 11224000.0 17695000.0 False True 12131690.312958263 9549422.950809328 15864091.142425522 1.0 0.7871469436216378 1.3076571139868742 23.532277239915516 -6.795679688499262 1.473475491195179 0.8819049403505919 1.3140985186475453 0.8192048104245853 0.0908521168834186 0.22700070495907443 0.9733871001391008 0.04851664395487776 0.11314222571335653 1.6007382089841168e-07 6.795679688499262 0.4321935782969535 HGLINFGIYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGLINFGIYK 10 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 22236500.0 9399100.0 4321600.0 8515800.0 False True 9100730.71530723 6047237.416846281 6285256.511476079 1.0 0.6644782277399945 0.6906320720933337 23.117550956067053 -10.766465294512438 6.96324184620179 1.0076259996870682 0.6775551499169364 0.9950899725518014 0.010677262246308656 0.0012749193301485023 4.27584621901801e-05 0.010426971695399403 0.003446071571920218 1.7121219909079737e-11 10.766465294512438 -0.3300708497701318 HGLINFGIYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGLINFGIYK 10 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 52908000.0 15043000.0 12233000.0 25632000.0 False True 22821330.790611092 10049925.573134752 20565823.96509531 1.0 0.4403742124131247 0.9011667265940636 24.44387958682127 -10.07589483520985 7.347880988427486 1.0000000533683788 0.6707704695035989 0.4049930163652191 0.18811775617291376 1.645861428990438e-07 2.06852892533169e-08 0.18214426405151948 0.06071474473196687 8.39663287105984e-11 10.07589483520985 -0.32922958386477996 HGLINFGIYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGLINFGIYK 10 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 38962700.0 9253700.0 12282000.0 17427000.0 False True 12675042.961839588 11739340.628857318 13311101.520331161 1.0 0.9261775809518465 1.0501819647007538 23.595487301438407 -6.7454957116751215 1.6670699087777254 0.9563562885939588 1.050337985516964 0.6291336241876515 0.031015945633836913 0.30796771273455315 1.6825603399361784 0.014708085174641118 0.03586999486631736 1.7968188222934998e-07 6.7454957116751215 0.09398169692300506 HGLINFGIYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGLINFGIYK 10 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 24691500.0 9399100.0 6045700.0 9246700.0 False True 7815768.100730482 6013130.6141225025 11180142.218089765 1.0 0.7693588827898438 1.4304598184079746 22.89795623150133 -6.812469430873039 1.404225203783858 0.8746664010927279 1.4426798443543907 0.866157714524789 0.10023114600792912 0.20345040849678467 0.7902115535076625 0.056118948311749184 0.1296695883840374 1.540034922247371e-07 6.812469430873039 0.5680134432616628 HGLINFGIYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGLINFGIYK 10 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 60656000.0 15043000.0 24004000.0 21609000.0 False True 19473460.041861165 22668156.298788138 17676383.72706379 1.0 1.1640538584339652 0.9077166404463158 24.21500590891372 -6.733816582858099 1.7090923656001076 1.0983019552900297 0.9077526694881864 0.5769969773672194 0.0689459990965607 0.3291127455672363 1.8849675786740092 0.03194496055198874 0.07893576185462395 1.8457947957074527e-07 6.733816582858099 -0.19054928580184327 HGLLVPNNTTDQELQHIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGLLVPNNTTDQELQHIR 18 0 P56537;B7ZBH1 P56537 EIF6 Eukaryotic translation initiation factor 6 0 21041200.0 4245000.0 6910000.0 9886200.0 False True 5565236.10863848 5879054.934969042 8863270.859126734 1.0 1.0563891307043463 1.5926136261081487 22.40801146543336 -6.92702854411257 0.770780179528252 0.9908852020558778 1.6948106459628085 0.9959216953657306 0.017055117952267072 0.0942096408800038 0.0854518612408609 0.015271908068701946 0.049335219965251385 1.1829638025806065e-07 6.92702854411257 0.7039254439069307 HGLLVPNNTTDQELQHIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGLLVPNNTTDQELQHIR 18 0 P56537;B7ZBH1 P56537 EIF6 Eukaryotic translation initiation factor 6 0 23385400.0 4913900.0 6873200.0 11598300.0 False True 4757910.934232873 9617704.603264492 8560357.288458291 1.0 2.021413333752363 1.7991840130648629 22.181896834793985 -10.031915811693922 5.309892773732429 0.9999934133341385 1.9102986734103364 0.9572136682372036 0.09072474026765502 7.0758312771950886e-06 1.2897921907061919e-06 0.08784448630281085 0.029281284011263613 9.291464850556563e-11 10.031915811693922 0.9103052600761979 HGLLVPNNTTDQELQHIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGLLVPNNTTDQELQHIR 18 0 P56537;B7ZBH1 P56537 EIF6 Eukaryotic translation initiation factor 6 0 79157900.0 9612200.0 54868000.0 14677700.0 False True 14582410.145949071 45076376.71435931 11776646.161535563 1.0 3.091147228970331 0.8075925751414325 23.797725848776857 -6.66584228326818 1.9522887016625088 2.339505918934307 0.816999500491716 0.26074388517199676 0.8891318775693584 0.47069961940087 3.4546605988547374 0.3671912735758921 0.9863293540400295 2.158528149704886e-07 6.66584228326818 -1.5225064184425907 HGLLVPNNTTDQELQHIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGLLVPNNTTDQELQHIR 18 0 P56537;B7ZBH1 P56537 EIF6 Eukaryotic translation initiation factor 6 0 22507700.0 4245000.0 7710700.0 10552000.0 False True 5814491.21681156 7370015.778124907 8059834.925261633 1.0 1.267525481303648 1.3861634018739357 22.471221526956253 -12.936126820186471 0.12073792051555551 7.930322153904291e-20 1.5843200869449143 0.9997181300102508 0.0027115693576566084 8.21951218008031 0.09683779998641052 2.133799912964986 0.1637875421649987 1.158439026031396e-13 12.936126820186471 1.5843200869449143 HGLLVPNNTTDQELQHIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGLLVPNNTTDQELQHIR 18 0 P56537;B7ZBH1 P56537 EIF6 Eukaryotic translation initiation factor 6 0 13605100.0 4913900.0 5100700.0 3590500.0 False True 4086125.5726803103 5073221.516690318 4341256.949403713 1.0 1.2415725915546245 1.062438457209735 21.96230211022826 -10.301105484116484 4.686304613489541 0.9999193474203366 1.1520055243824119 0.4898129193200239 0.07313120411104684 6.165828369699515e-05 9.195540324543284e-06 0.0708465013164592 0.023602994634037058 4.99913098260075e-11 10.301105484116484 0.15208617696207527 HGLLVPNNTTDQELQHIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGLLVPNNTTDQELQHIR 18 0 P56537;B7ZBH1 P56537 EIF6 Eukaryotic translation initiation factor 6 0 43988200.0 9612200.0 14859200.0 19516800.0 False True 12443182.384788796 14032272.457713427 15964942.659278937 1.0 1.1277076895430882 1.2830272968429142 23.568852170869306 -6.96850777941767 0.2916326729248462 0.970238172343364 1.445306518881826 0.999968289058752 0.0006516704862027207 0.07678990321485384 0.010754235897096603 0.0026899494291676655 0.01405868037716393 1.0752073402771912e-07 6.96850777941767 0.47506834653846197 HGLTEADVGITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGLTEADVGITK 12 0 Q96PZ0;Q96PZ0-2;E7EUH7 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 5357900.0 1406300.0 2290200.0 1661400.0 False True 1843672.918628574 1948511.0871296814 1489494.2652741335 1.0 1.0568637568203212 0.8078950719643383 20.814151302896494 -6.846650323433917 1.2511870536954595 1.0302781666492666 0.7985693258110207 0.9352823646989679 0.02709893702378578 0.1611803040382039 0.48725030714787126 0.01696170937668606 0.039174599806334205 1.4234744505972813e-07 6.846650323433917 -0.23170884083824594 HGLTEADVGITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGLTEADVGITK 12 0 Q96PZ0;Q96PZ0-2;E7EUH7 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 6322900.0 1406300.0 2882600.0 2034000.0 False True 1926247.1138285275 2755237.2005165336 1553611.0915449364 1.0 1.430365388083744 0.806548173591832 20.877361364419386 -6.72110254542192 1.7555039900362603 1.261522277699462 0.8074701759403312 0.5176516068301458 0.18107516626382403 0.353176627963819 2.1277435573577277 0.08188428261630792 0.20528196696612522 1.900629451147281e-07 6.72110254542192 -0.4540521017591307 HGLVPFAFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGLVPFAFVR 10 0 Q13242;H0YIB4;S4R3G0 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 0 8208900.0 0.0 2604900.0 5604000.0 False True 0.0 3645050.1543740467 4136144.283603649 0.0 HGLVPFAFVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGLVPFAFVR 10 0 Q13242;H0YIB4;S4R3G0 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 0 28015000.0 12839000.0 0.0 15176000.0 False True 19477701.65662804 0.0 12176456.948122911 1.0 0.0 0.6251485500076649 24.215320115543093 -10.193698531400813 7.063059846234259 1.0000013876190506 0.3125742750038325 0.6171835990431105 0.25521582682659205 5.576662544240557e-06 6.365578680611814e-07 0.24711216240596892 0.08237055391566224 6.401790661275024e-11 10.193698531400813 -0.687427112615218 HGLVPFAFVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGLVPFAFVR 10 0 Q13242;H0YIB4;S4R3G0 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 HGLVPFAFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGLVPFAFVR 10 0 Q13242;H0YIB4;S4R3G0 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 0 26087000.0 12839000.0 0.0 13248000.0 False True 16620338.594526047 0.0 10836999.93595915 1.0 0.0 0.6520324405140786 23.986446437635543 -10.309852725111602 7.550539950404521 1.0000041463396443 0.32601622025703936 0.5875643382259249 0.26619112916685306 1.8579919482975276e-05 1.6984121215478441e-06 0.25774003736471746 0.08591281751428077 4.8994493787977796e-11 10.309852725111602 -0.6739879260826049 HGLYLPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGLYLPTR 8 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 26939100.0 7988100.0 11296000.0 7655000.0 False True 10472476.45687044 9610680.831463123 6862934.03194504 1.0 0.9177085163230958 0.6553305763168015 23.320099305103064 -6.950073764501821 0.5580315324577417 1.0034675567774463 0.5570743331808526 0.999207069817527 0.004138627201292371 0.08345610490079595 0.035839639990813424 0.004446993927459025 0.02180151479158811 1.1218278967255439e-07 6.950073764501821 -0.4463932235965936 HGLYLPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGLYLPTR 8 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 8745000.0 3050800.0 1935500.0 3758700.0 False True 2953954.023923489 2708355.243499158 2774183.711417033 1.0 0.9168576157803151 0.9391424812131361 21.494215941136503 -10.578322989690859 6.350346016557484 1.0001511949484325 0.9280000484967257 0.9329677648421548 0.009097758216166424 1.9515509504598053e-05 1.295864513185493e-06 0.00882732328730947 0.002936288838252851 2.6404442987944935e-11 10.578322989690859 -0.07215114645170684 HGLYLPTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGLYLPTR 8 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 42473000.0 12243000.0 19943000.0 10287000.0 False True 18573526.083191644 16384015.834629798 8253769.941047724 1.0 0.8821166084051605 0.4443835760683633 24.146744393315142 -6.946585509569432 0.5951550225773005 1.0049877230948725 0.2992905944414954 0.9989053210906365 0.007908514765010106 0.08488658881432781 0.041865718443566256 0.00815610729208662 0.03672903755643928 1.1308747060308131e-07 6.946585509569432 -0.7056971286533771 down HGLYLPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGLYLPTR 8 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 22701500.0 7988100.0 7009000.0 7704400.0 False True 10941516.440285606 6699319.204336502 5884779.397098717 1.0 0.6122843429335129 0.5378394694387634 23.383309366625955 -13.999999999999995 0.23203210381982725 3.470776724357776 0.5023365448998846 0.9995126349845295 0.004472887697594708 13.355440432779298 0.15250579846753914 15.219980846545692 0.03816104651013662 1.0000000000000123e-14 13.999999999999995 -2.9684401794578914 HGLYLPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGLYLPTR 8 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 11199100.0 3050800.0 4856500.0 3291800.0 False True 2536875.373355802 4830337.070560227 3980100.160436463 1.0 1.904049809183418 1.5688985758774385 21.27462121657078 -10.024087541717547 4.977793568420606 0.9999916076228847 1.7364741925350018 0.8655609333218893 0.13682491807334024 1.551212936018839e-05 3.041479170151224e-06 0.1324819932838999 0.044160052416130594 9.460464454306767e-11 10.024087541717547 0.736482584912117 HGLYLPTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGLYLPTR 8 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 28559400.0 12243000.0 7564300.0 8752100.0 False True 15848804.845609687 7143340.055445891 7159307.604129538 1.0 0.45071790113086563 0.451725393420612 23.91787071540759 -10.233636665588339 8.07579117130052 1.0000003551458316 0.451221647275739 0.9999974716613264 0.0004113070049444876 2.630071807627833e-09 2.4984247068533566e-10 0.0003982465561753016 0.00013274876502737394 5.839334235864934e-11 10.233636665588339 -0.5487787078700926 HGNQYIQVNEPWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGNQYIQVNEPWK 13 0 P56192 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 18886600.0 1839600.0 6270300.0 10776700.0 False True 2411733.414711739 5334795.681437961 9661630.461405907 1.0 2.21201715284755 4.006093875247281 21.20163901448553 -6.96547666010463 0.3497750451967616 0.8261747408357106 5.452453958369881 0.9999226368211934 0.010861527221663787 0.07779957357827294 0.014291690159160217 0.024640605242124698 0.15422885523515406 1.0827379021670999e-07 6.96547666010463 4.62627921753417 HGNQYIQVNEPWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGNQYIQVNEPWK 13 0 P56192 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 8705100.0 1976900.0 2431100.0 4297100.0 False True 1914144.3916003495 3401850.90801902 3171560.5997632523 1.0 1.7772174988193294 1.6569077096172566 20.868268231535065 -10.09761135512074 4.378114281803857 0.9999210032279912 1.717062604266695 0.9793235836052125 0.04911626596555237 11393693.237709252 1.5992832340389198 9224.934426991844 0.016813804226739483 7.987091226843558e-11 10.09761135512074 0.7171416010387038 HGNQYIQVNEPWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGNQYIQVNEPWK 13 0 P56192 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 19513600.0 1839600.0 8839700.0 8834300.0 False True 2519749.833320737 8449132.825021153 6747820.288119668 1.0 3.353163363001866 2.677972312523909 21.26484907600842 -10.076541634187008 6.681278236492246 0.9999986369464631 3.0155678377628905 0.9223707647772654 0.27564559209413675 5.5965723704888255e-06 7.738222142575804e-07 0.2668928797320563 0.08896423230300454 8.384136991847301e-11 10.076541634187008 2.0155692008164277 HGNQYIQVNEPWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGNQYIQVNEPWK 13 0 P56192 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 9889400.0 1976900.0 4646900.0 3265600.0 False True 1643879.9415193019 4621866.227362563 3948421.861571574 1.0 2.811559476229727 2.4018918668247604 20.64867350696934 -10.085385678594902 5.231387835978991 0.9999736224840016 2.6067256715295564 0.953509310036128 0.16724610120607517 5.1454205293631066e-05 8.995766848586309e-06 0.1619379811061517 0.05397844705627355 8.215127750955074e-11 10.085385678594902 1.606752049045555 HGNQYIQVNEPWKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGNQYIQVNEPWKR 14 1 P56192 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 37967400.0 7887400.0 14970000.0 15110000.0 False True 11965762.446178677 12298486.538856138 12123501.877051735 1.0 1.0278063428196937 1.0131825641351784 23.51240899107336 -10.081466969275532 4.270822978129186 0.9999975602225011 1.020494453480536 0.723660453587319 0.0059701326588673465 1.3915670736106688e-07 2.991734353396763e-08 0.005781246385377516 0.0019268520287043455 8.2895896122293e-11 10.081466969275532 0.020496893258034943 HGNQYIQVNEPWKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGNQYIQVNEPWKR 14 1 P56192 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 27712100.0 7887400.0 9752700.0 10072000.0 False True 10210394.783897873 9209953.671687681 8238999.347447198 1.0 0.9020173917478763 0.8069227019938906 23.28353531316581 -6.971492498068165 0.21966790635747666 1.0440377934266767 0.6622182437854826 0.9999917891093777 0.00022580055010343282 0.07582160967269025 0.0072736565397342095 0.0026407589964088348 0.009645109293358512 1.0678432381291942e-07 6.971492498068165 -0.38181954964119413 HGQFTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGQFTLR 7 0 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 0 7830600.0 1965000.0 1655000.0 4210600.0 False True 1902622.1505866183 2315850.130710986 3107717.544707629 1.0 1.217188673009489 1.6333866100263021 20.85955764874996 -6.9608722830296905 0.42296031939755535 0.9821791376889508 1.8841726837840875 0.9998011956457111 0.0037054100134804382 0.07939097227599261 0.019990746076206187 0.005394809956965382 0.03461761015336478 1.0942781233850404e-07 6.9608722830296905 0.9019935460951367 HGQFTLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGQFTLR 7 0 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 0 16071800.0 4886600.0 7003800.0 4181400.0 False True 7413329.458312841 5753917.169060835 3354944.4572272715 1.0 0.7761582972153968 0.452555693914999 22.821690197441058 -6.965862977406118 0.3429182513355722 1.0339337630446879 0.18397825604857565 0.9999298451095534 0.0018822690841854338 0.07766931549152958 0.013834082830815159 0.004528509435642442 0.02795024021806792 1.0817752042259523e-07 6.965862977406118 -0.8499555069961122 down HGQFTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGQFTLR 7 0 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 0 8832100.0 1527600.0 2788100.0 4516400.0 False True 2092395.001837772 2664912.5229862463 3449719.33817775 1.0 1.273618279839909 1.6486941209225916 20.996723798251004 -6.966711125693291 0.32736413517513063 0.95287635786707 1.9816663716071563 0.999944190703267 0.0019864571622638548 0.07738506908177967 0.012838209527714422 0.005525535568032242 0.032785374668251446 1.0796646306548846e-07 6.966711125693291 1.0287900137400863 HGQFTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGQFTLR 7 0 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 0 6066400.0 1965000.0 2632200.0 1469200.0 False True 1633984.5642599156 2618019.8161492045 1776402.927186724 1.0 1.6022304453867287 1.087160164203457 20.639962924184236 -10.229379884465994 4.282049581303963 0.9998271769161503 1.3446953048069972 0.37388098591860897 0.2102765618018305 0.00034710622539201844 6.246710599016682e-05 0.2037008778103691 0.06786646849079142 5.896850473857987e-11 10.229379884465994 0.34486812789084687 HGQFTLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGQFTLR 7 0 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 0 11726200.0 4886600.0 3535500.0 3304100.0 False True 6325800.029286625 3338746.3170457203 2702787.7029289403 1.0 0.5277982708255541 0.42726417060542776 22.592816519533507 -13.999999999999998 0.21741177484668678 3.8175646304864954 0.3721362148183123 0.9994954355052819 0.005608672139779665 12.930527104649467 0.14773343520827978 15.620501851694817 0.0566034708476909 1.0000000000000041e-14 13.999999999999998 -3.445428415668183 HGQK(ub)GTCGIQYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGQKGTCGIQYR 12 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 13789300.0 2249800.0 3940800.0 7598700.0 True False 2949509.5870941933 3352848.001118089 6812459.415877304 1.0 1.1367476192614305 2.309692243648146 21.492043667838296 -6.928822475882957 0.7563936421853215 0.9813627262015227 2.5434281347310126 0.9963018093852166 0.03574695971599114 0.09325355347770571 0.08070874681912031 0.03234214244127257 0.10682640326792563 1.1780874352985029e-07 6.928822475882957 1.5620654085294898 up HGQK(ub)GTCGIQYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGQKGTCGIQYR 12 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 10136700.0 2630600.0 2989800.0 4516300.0 True False 2547093.042917638 4183642.7316010264 3333345.5439042035 1.0 1.642516649807483 1.3086862111978175 21.280420230194288 -10.019817288015425 4.358740960072632 0.9999757964357201 1.4756014304791247 0.7301878826108563 0.13628570617397662 15538268.050548648 7143834.290841811 3551.9425435753533 0.04665422265477341 9.553944453763323e-11 10.019817288015425 0.47562563404340463 HGQK(ub)GTCGIQYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGQKGTCGIQYR 12 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 62812300.0 5465300.0 11401000.0 45946000.0 True False 8291259.6669498645 9366402.47358042 36864752.96115278 1.0 1.1296718291089383 4.446218601511289 22.98315987215558 -6.915148598507633 0.8599437332075535 0.913266909289947 4.9255933765055175 0.9927236377472092 0.13604563075874085 0.10111080663038938 0.12103022084727734 0.11429966409180212 0.3279919209526026 1.215769940766429e-07 6.915148598507633 4.012326467215571 up HGQK(ub)GTCGIQYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGQKGTCGIQYR 12 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 13643520.0 2249800.0 5059520.0 6334200.0 True False 3081611.8585589267 4835973.676804763 4838192.416943919 1.0 1.5693000607371232 1.5700200541175335 21.555253729361187 HGQK(ub)GTCGIQYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGQKGTCGIQYR 12 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 12841400.0 2630600.0 2259200.0 7951600.0 True False 2187460.455339509 2247029.241183909 9614242.795955587 1.0 1.0272319372443945 4.395161874806734 21.060825505628564 -6.908671571860927 0.90473270285267 0.8912909630788266 4.818267345978842 0.9904105718573444 0.15610468835900743 0.10530300826336815 0.1435803409590959 0.12697147627066038 0.34735555981543875 1.2340377013939708e-07 6.908671571860927 3.926976382900015 up HGQK(ub)GTCGIQYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGQKGTCGIQYR 12 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 36401900.0 5465300.0 4775600.0 26161000.0 True False 7074938.587169038 4509833.661910218 21399966.434528016 1.0 0.6374378528301516 3.024756493764985 22.754286194248028 -6.868183802998638 1.1435996975626477 0.7970187441690795 3.159862831775633 0.9628398786009308 0.2024884477510435 0.1386114206114511 0.3399337832672288 0.13755557314054545 0.3246948688565533 1.3546159876685108e-07 6.868183802998638 2.362844087606554 up HGSFVNKPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGSFVNKPTR 10 1 P29353-2;P29353-7;P29353;P29353-6;Q5T182;Q5T181 P29353-2 SHC1 SHC-transforming protein 1 0 3019100.0 1140500.0 1878600.0 0.0 False True 1495206.5446177116 1598320.2027254452 0.0 1.0 1.0689628188686784 0.0 20.511913358305097 -6.977390620984867 1.1574746716302 1.0463611933269468 7.662575932306574e-22 0.9791959624916682 0.0704551610565635 0.09783189913233184 0.2584336509806949 0.05103025800893649 0.09496856640938484 1.0534389670558553e-07 6.977390620984867 -1.0463611933269468 down HGSFVNKPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGSFVNKPTR 10 1 P29353-2;P29353-7;P29353;P29353-6;Q5T182;Q5T181 P29353-2 SHC1 SHC-transforming protein 1 0 3318760.0 893260.0 1145300.0 1280200.0 False True 864903.9502458031 1602624.2626606007 944877.2148232318 1.0 1.8529505642853634 1.0924649084498927 19.72218040117684 -10.295966942323854 5.564347237762121 0.9999428419897822 1.472707736367598 0.34000367959998934 0.310466968917153 0.00022018680676541943 2.7859624755732935e-05 0.30064453679848896 0.10020278334696445 5.058631658869443e-11 10.295966942323854 0.47276489437781577 HGSFVNKPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGSFVNKPTR 10 1 P29353-2;P29353-7;P29353;P29353-6;Q5T182;Q5T181 P29353-2 SHC1 SHC-transforming protein 1 0 5888500.0 1140500.0 2278400.0 2469600.0 False True 1562173.670853612 2177732.7543387483 1886331.3430085392 1.0 1.394040108964824 1.207504247576903 20.57512341982799 -10.14116493033805 4.409057996656642 0.9999516742816688 1.300772178241404 0.776110319587718 0.07615294656787025 53225082.48773195 2.5820482846417643 26561.977500530837 0.02606917915296979 7.224953722185265e-11 10.14116493033805 0.30082050395973514 HGSFVNKPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGSFVNKPTR 10 1 P29353-2;P29353-7;P29353;P29353-6;Q5T182;Q5T181 P29353-2 SHC1 SHC-transforming protein 1 0 2527990.0 893260.0 1123600.0 511130.0 False True 742785.2681276401 1117546.9437828632 618004.9198018984 1.0 1.5045356871440052 0.8320102004173036 19.502585676611115 -6.7059428334779145 1.8096414679441297 1.3114549288683475 0.833769945195745 0.4458225705687655 0.2127486104838976 0.3832920768967014 2.444182435584214 0.09364706816007662 0.2390876801239008 1.9681453411664034e-07 6.7059428334779145 -0.4776849836726025 HGSNIEAMSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGSNIEAMSK 10 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 11939700.0 1986000.0 5739700.0 4214000.0 False True 2603665.2324513574 4883359.133175365 3777975.7035423107 1.0 1.8755710497304101 1.4510220655308044 21.312112534521333 -10.112648996362516 4.552667011873662 0.9999402304548832 1.6632965576506173 0.7649606882282153 0.17332139708343466 27042288.58531867 30033963.703811634 13442.262134293194 0.059332526545457946 7.71526777234468e-11 10.112648996362516 0.6633563271957341 HGSNIEAMSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGSNIEAMSK 10 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 6805900.0 1850800.0 1730600.0 3224500.0 False True 1792047.367076701 2421637.6049597743 2379906.717073517 1.0 1.351324551710985 1.3280378414080476 20.773177340281926 -10.25173062825551 5.131118280326254 0.9999508420796773 1.3396811965596007 0.9964875788734866 0.009506759672088978 5.34713895576539e-06 7.798013789604254e-07 0.009206209634199589 0.0030682934904774106 5.6010489960550446e-11 10.25173062825551 0.3397303544799234 HGSNIEAMSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGSNIEAMSK 10 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 4643340.0 984740.0 2570800.0 1087800.0 False True 1493922.574137232 2112020.654247922 872795.8532003221 1.0 1.4137417097854974 0.5842309824552842 20.510673948507012 -6.771115835897585 1.5704495442641673 1.2369752581768956 0.5793964790671832 0.7347166820031995 0.17442220969364777 0.26462828791448045 1.2882364671199178 0.08754098984476692 0.208148575870529 1.6938859435246308e-07 6.771115835897585 -0.6575787791097124 HGSNIEAMSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGSNIEAMSK 10 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 11865200.0 1986000.0 5539500.0 4339700.0 False True 2720277.869631978 5294746.573323159 3314752.2389270156 1.0 1.946399164743959 1.2185344283874437 21.375322596044224 -10.219410225640281 4.998369322644336 0.9999303932862422 1.582466796465426 0.4605809692763526 0.2971495343150276 0.00024190917138589718 3.777803213133548e-05 0.28774966896086257 0.09590459981000937 6.033784212616215e-11 10.219410225640281 0.5825364031791838 HGSNIEAMSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGSNIEAMSK 10 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 4967700.0 1850800.0 1897800.0 1219100.0 False True 1539022.204342115 1887576.1747161953 1474008.1735184675 1.0 1.2264775448922627 0.9577562749645714 20.553582615716202 -6.683301062408934 1.890721856888256 1.1428717698610287 0.9587647422107124 0.33909556830605836 0.09591849371041386 0.43120145564783036 2.9832057231763716 0.040670564008602236 0.10679232224922494 2.0734756405820254e-07 6.683301062408934 -0.18410702765031628 HGSYEDAVHSGALND ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGSYEDAVHSGALND 15 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 11149800.0 1747100.0 4904000.0 4498700.0 False True 2290465.0189404693 4172342.31564228 4033217.678577549 1.0 1.821613637903248 1.7608728556104505 21.127209098830832 -10.200506034114039 4.688616070274587 0.9998588146093578 1.7912432467613892 0.9955996547335724 0.024797320548031288 3.66030582210243e-05 6.241474541502059e-06 0.02401412905209062 0.008003300790555643 6.302225895788955e-11 10.200506034114039 0.7913844321520315 HGSYEDAVHSGALND ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGSYEDAVHSGALND 15 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 7017600.0 1881200.0 1069800.0 4066600.0 False True 1821482.3357168173 1496976.7189332996 3001435.464615023 1.0 0.8218453122380606 1.6477982826190039 20.79668157357461 -6.850262273490999 1.2339075913329796 0.9049125557231025 1.6809684477815365 0.9406742735851581 0.08644231067703642 0.15717015366866463 0.4603671260138703 0.0548163250573431 0.12686325684919822 1.4116847607954763e-07 6.850262273490999 0.7760558920584341 HGSYEDAVHSGALND ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGSYEDAVHSGALND 15 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 9018800.0 1747100.0 4108600.0 3163100.0 False True 2393050.0836022333 3927068.4666766915 2416040.9260893697 1.0 1.6410306217934714 1.0096073386197286 21.190419160353724 -3.0113839177816497 0.0017690340038398573 1.6376250063109918 0.9417307975708172 0.0 0.3097484432614028 58909820.80423085 9195.605044291626 1768745.9651989236 1849540.4471810583 0.0009741281244471582 3.0113839177816497 -0.6958942087401746 HGSYEDAVHSGALND ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGSYEDAVHSGALND 15 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 12008500.0 6414400.0 3321800.0 2272300.0 False True 8303567.2467269935 3136938.9099031244 1858764.7157669044 1.0 0.3777820804834943 0.22385134732299197 22.98529982669174 -13.999999999999998 0.1961685246055008 4.409634399948513 0.12002119310905075 0.9994871820573863 0.007598361189283317 12.457725175233573 0.14045151140891196 16.27259465264832 0.1008907983940158 1.0000000000000041e-14 13.999999999999998 -4.289613206839462 HGVESTLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGVESTLER 9 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 10015200.0 2077100.0 4207900.0 3730200.0 False True 2723098.21466501 3580097.7222657306 3344234.6866050195 1.0 1.3147148725614903 1.2280991807768564 21.376817586687473 -10.052697866120619 4.392747000953574 0.9999817809430145 1.2714070265941593 0.9290349804730382 0.0353607082061753 24498831.541036103 0.08096749983531183 4639.345552577533 0.012104910942689406 8.85731589235088e-11 10.052697866120619 0.2714252456511448 HGVESTLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGVESTLER 9 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 5158500.0 1703500.0 1364700.0 2090300.0 False True 1649423.3249487565 1909631.826816483 1542787.7223441675 1.0 1.1577572585108256 0.9353497667993134 20.653530283700338 -6.716186234386053 1.7731216598521826 1.0963659768382519 0.9357700359149621 0.49445273167755877 0.06641760751048463 0.3627656938614003 2.2268269569954655 0.02976725784487363 0.0750618833227109 1.922267244503339e-07 6.716186234386053 -0.16059594092328977 HGVESTLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGVESTLER 9 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 18289000.0 2634500.0 12645000.0 3009500.0 False True 3996729.1077487823 10388400.954164058 2414671.005889291 1.0 2.599225685329342 0.6041617885004448 21.930388361709362 -6.693286958905028 1.8549244049558802 1.99951155641518 0.6108037751114985 0.38580082851981035 0.6759150670853997 0.4096232850996224 2.735126300520644 0.2912463520586806 0.7552459924206333 2.0263433761776214e-07 6.693286958905028 -1.3887077813036814 HGVHMMVATPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGVHMMVATPGR 12 0 Q9UJV9 Q9UJV9 DDX41 Probable ATP-dependent RNA helicase DDX41 0 6794900.0 2340000.0 1738900.0 2716000.0 False True 3067762.6605922338 1479462.8981791127 2434974.373711655 1.0 0.4822611987504605 0.7937297122071306 21.548755441463726 -10.333838076264064 5.978117908185364 1.0000376981029884 0.6379954554787989 0.6429977397992996 0.12715648815200792 6.389532935236213e-05 7.1203600099503e-06 0.12313152787134979 0.04103958008124537 4.636197449762214e-11 10.333838076264064 -0.3620422426241895 HGVHMMVATPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGVHMMVATPGR 12 0 Q9UJV9 Q9UJV9 DDX41 Probable ATP-dependent RNA helicase DDX41 0 4849020.0 871330.0 739890.0 3237800.0 False True 843670.1060919282 1035331.9354753772 2389723.0480820676 1.0 1.2271762718620791 2.832532563174258 19.68631945755891 -6.932480326124817 0.7261501034532831 0.9776928826175476 3.183927541923696 0.9970035730665787 0.0446461001711944 0.09137027347746546 0.0715213132812907 0.041292213488956175 0.14332743008258686 1.1682066493254099e-07 6.932480326124817 2.206234659306148 up HGVHMMVATPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGVHMMVATPGR 12 0 Q9UJV9 Q9UJV9 DDX41 Probable ATP-dependent RNA helicase DDX41 0 8034300.0 1720900.0 2248400.0 4065000.0 False True 2610731.1146422005 1847155.4531706206 3261550.9682472073 1.0 0.707524203779895 1.2492864354949864 21.316022448059588 -6.760071922015044 1.6120895062707372 0.8301283073506104 1.2512797642291846 0.6912897510319521 0.12301785476794616 0.2828040286505386 1.4485351291354853 0.06020685911377543 0.14468264043211104 1.7375130613614274e-07 6.760071922015044 0.42115145687857425 HGVHMMVATPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGVHMMVATPGR 12 0 Q9UJV9 Q9UJV9 DDX41 Probable ATP-dependent RNA helicase DDX41 0 5847100.0 2340000.0 1227900.0 2279200.0 False True 3205161.2361222706 1173647.3178776973 1740899.9015974493 1.0 0.36617418950742764 0.543155171720365 21.611965502986617 -10.839667019847097 10.945181926872177 1.0095893680940609 0.4546646806143662 0.926790289345326 0.07225218343304703 0.01625497209718495 0.00023811414153456523 0.06725997700955202 0.023319291930276216 1.4465484362578267e-11 10.839667019847097 -0.5549246874796947 HGVHMMVATPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGVHMMVATPGR 12 0 Q9UJV9 Q9UJV9 DDX41 Probable ATP-dependent RNA helicase DDX41 0 3519290.0 871330.0 1808900.0 839060.0 False True 724549.501463915 1799155.096661464 1014503.5666248928 1.0 2.4831362012207085 1.4001853076637836 19.466724732993185 -10.45456457163925 5.100730481275659 0.9984448390031863 1.9416607544422795 0.5020205937840729 0.4421128509510438 0.007829117715666982 0.0008371889367856924 0.4286363235578815 0.14269130907312277 3.51103717939765e-11 10.45456457163925 0.9432159154390932 HGVIVAADSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGVIVAADSR 10 0 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 0 30142800.0 8811600.0 9968200.0 11363000.0 False True 11552092.931655787 8480983.41573926 10187265.761592617 1.0 0.7341512456586222 0.8818545541368368 23.461650917461625 -10.118564380800775 4.902574255743251 1.0000091620114158 0.8080029000913657 0.6925848026740165 0.060299623185307426 6.038792467187569e-06 1.0857043900544577e-06 0.058387644745538196 0.019461619697813976 7.610893050346635e-11 10.118564380800775 -0.1920062619200501 HGVIVAADSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGVIVAADSR 10 0 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 0 17785700.0 5589000.0 4603100.0 7593600.0 False True 5411580.254263922 6441141.83484939 5604608.356883057 1.0 1.1902515591031382 1.0356694520915668 22.367618511266784 -10.010853675338163 5.520374965619332 0.999999608737694 1.1129605055974563 0.41588424220793574 0.06310788092414171 3.0387691897232223e-07 5.442992228354873e-08 0.06110415419803385 0.02036798098608375 9.753181914324006e-11 10.010853675338163 0.1129608968597623 HGVIVAADSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGVIVAADSR 10 0 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 0 36301500.0 7444000.0 19754000.0 9103500.0 False True 11293092.229296621 16228744.361293562 7304189.2347941995 1.0 1.4370505466335284 0.6467838114210755 23.428937237395036 -6.756581708405848 1.6253493030677508 1.2549410862717632 0.6443761696102738 0.6768443952324776 0.1837456096443695 0.28870337784512967 1.5023578237656923 0.08923228902911662 0.21516827787015017 1.7515328688371954e-07 6.756581708405848 -0.6105649166614894 HGVIVAADSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGVIVAADSR 10 0 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 0 18693900.0 8811600.0 4874700.0 5007600.0 False True 12069486.644536331 4659319.63552277 3824908.0147593003 1.0 0.386041243736905 0.31690726601787794 23.524860978984517 -13.999999999999998 0.30829229121792134 6.875821476933239 0.301315150019039 0.9996682361652452 0.005592141433559112 17.14910509997661 0.17660521749490155 64.57788801999862 0.02412636282460684 1.0000000000000041e-14 13.999999999999998 -6.5745063269142 HGVIVAADSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGVIVAADSR 10 0 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 0 11579600.0 5589000.0 4519000.0 1471600.0 False True 4647501.134681256 4494655.250048726 1779304.756090376 1.0 0.9671122437191159 0.3828519250512045 22.14802378670106 -6.918492907680941 0.8358328187945628 1.0136050548497235 0.2918265016191096 0.9937517881962749 0.022408865974879462 0.09906683916633857 0.11027082801339541 0.01915496259737475 0.056576630677797855 1.2064437900692945e-07 6.918492907680941 -0.7217785532306139 down HGVIVAADSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGVIVAADSR 10 0 P28074;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 0 20120000.0 7444000.0 6427000.0 6249000.0 False True 9636404.7431772 6069331.800212945 5111746.120154645 1.0 0.6298336321448281 0.5304619571706846 23.200063559487486 -13.999999999999968 0.18457470484937896 2.9485520690871736 0.45514501660792256 0.9994933280700637 0.004547681309646776 12.267357402229267 0.13622521108539082 8.58252300828088 0.07140747691138284 1.0000000000000737e-14 13.999999999999968 -2.493407052479251 HGVSHK(ub)VDDSSGSIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGVSHKVDDSSGSIGR 16 1 P41250 P41250 GARS Glycine--tRNA ligase 1 8044400.0 1391800.0 3484400.0 3168200.0 True False 1824663.278210374 2964541.1020848188 2840385.0555203506 1.0 1.624705849833529 1.5566625850585398 20.799198824178944 -10.076122742678013 4.621441626480496 0.9999696576580609 1.590684217429367 0.9901458311367592 0.02777854659513859 19290556.45231203 0.24360219215965115 6517.002590425069 0.009509335354467564 8.392227672776735e-11 10.076122742678013 0.590714559771306 HGVSHK(ub)VDDSSGSIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGVSHKVDDSSGSIGR 16 1 P41250 P41250 GARS Glycine--tRNA ligase 1 8399800.0 1391800.0 3291200.0 3716800.0 True False 1906386.071980761 3145783.901457024 2838968.389898824 1.0 1.6501295029859884 1.4891885917678247 20.862408885701836 -10.096666257703516 4.804085773531648 0.9999751206595509 1.5696590473132783 0.9435174718971759 0.06570385189370719 45720462.68413557 0.2995405002536659 13178.296334293527 0.0224921761196974 8.004491398964426e-11 10.096666257703516 0.5696839266537275 HGVVPLATYMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGVVPLATYMR 11 0 P46778;G3V1B3;M0R181 P46778 RPL21 60S ribosomal protein L21 0 34790350.0 7526950.0 13043400.0 14220000.0 False True 9867904.341087475 11097375.562774984 12748650.807871768 1.0 1.1245929408302326 1.2919309275009474 23.234312299624996 -6.967028768772795 0.3213406380636547 0.9774406458077399 1.4444912350779457 0.9999490572487905 0.0008536543544528446 0.07727916558089312 0.012467637853212421 0.0025228835850420986 0.014702081782962277 1.0788752524176573e-07 6.967028768772795 0.4670505892702058 HGVVPLATYMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGVVPLATYMR 11 0 P46778;G3V1B3;M0R181 P46778 RPL21 60S ribosomal protein L21 0 22183870.0 7929650.0 8848220.0 5406000.0 False True 7677927.601220956 12381360.38885774 3990006.42347633 1.0 1.6125914480997239 0.5196723166342221 22.872285525725246 -6.754565579392571 1.6326036839949174 1.3582082181213253 0.5166702290271813 0.6685609614954052 0.2574967395785048 0.29212460934576995 1.5331829309859668 0.12451554488116134 0.30089647428260297 1.7596829278653328e-07 6.754565579392571 -0.841537989094144 HGVVPLATYMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGVVPLATYMR 11 0 P46778;G3V1B3;M0R181 P46778 RPL21 60S ribosomal protein L21 0 91204100.0 28036200.0 44413300.0 18754600.0 False True 42532965.1207692 36487399.61230321 15047745.089566797 1.0 0.8578616493982948 0.3537901730302564 25.342078097964702 -6.9476423072567 0.584155408510755 1.0059362600064738 0.18060480885160324 0.9990030285756347 0.008754572128577144 0.08444654202619177 0.03998878496658115 0.009131784903540484 0.04215669867761537 1.1281262186860912e-07 6.9476423072567 -0.8253314511548706 down HGVVPLATYMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGVVPLATYMR 11 0 P46778;G3V1B3;M0R181 P46778 RPL21 60S ribosomal protein L21 0 45757850.0 7526950.0 18901800.0 19329100.0 False True 10309866.823175427 18066655.97610608 14763964.675310332 1.0 1.7523656014153608 1.4320228309955074 23.297522361147887 -10.17656081984962 4.747522838708815 0.9999287879761063 1.5921942162060196 0.8200325757779826 0.13077938840154274 0.00010102463174649468 1.75225281519158e-05 0.12664211997444622 0.042208866106675964 6.659462537371525e-11 10.17656081984962 0.5922654282299133 HGVVPLATYMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGVVPLATYMR 11 0 P46778;G3V1B3;M0R181 P46778 RPL21 60S ribosomal protein L21 0 23326950.0 7929650.0 11266800.0 4130500.0 False True 6593855.318057833 11206103.512115302 4994168.452725815 1.0 1.6994767054452096 0.7573973361303303 22.652690801159522 -6.7078474306712526 1.802689507889565 1.4309573166917313 0.7597287818583118 0.4549734976619575 0.2948559629497398 0.3794109737198971 2.402056599230048 0.13022444338182493 0.3317210953041001 1.959532944093873e-07 6.7078474306712526 -0.6712285348334195 HGVVPLATYMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGVVPLATYMR 11 0 P46778;G3V1B3;M0R181 P46778 RPL21 60S ribosomal protein L21 0 61943000.0 28036200.0 17342800.0 16564000.0 False True 36293413.57612367 16377657.934453553 13549521.960992401 1.0 0.4512570276725889 0.373332806862406 25.11320442005715 -13.999999999999991 0.27495001121632495 5.3502448584275895 0.34868289679947834 0.9995940645607277 0.0056185709199767595 15.131640965738471 0.16603883160601476 36.90368213651906 0.03158245630160794 1.0000000000000205e-14 13.999999999999991 -5.001561961628111 HGYIFSSLAGCLMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGYIFSSLAGCLMK 14 0 Q9Y3B2;R4GNH9;R4GMQ7;B1AMU3;B1AMU4;B1AMU7 Q9Y3B2 EXOSC1 Exosome complex component CSL4 0 11856100.0 3340900.0 3889600.0 4625600.0 False True 4379952.25332162 3309286.84154205 4146987.283888304 1.0 0.7555531773279924 0.9468110709981731 22.06248371214798 -9.882810582175344 5.449257234234258 1.000000121563363 0.8511821243486727 0.44667434340411205 0.07808070813190987 1.1530167629050816e-07 2.356772958287873e-08 0.07560138252226471 0.025200440187430402 1.30975304809764e-10 9.882810582175344 -0.14881799721469025 HGYIFSSLAGCLMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGYIFSSLAGCLMK 14 0 Q9Y3B2;R4GNH9;R4GMQ7;B1AMU3;B1AMU4;B1AMU7 Q9Y3B2 EXOSC1 Exosome complex component CSL4 0 24823700.0 7608400.0 4444300.0 12771000.0 False True 11542499.048546517 3651179.941525614 10246806.252271857 1.0 0.31632490729859636 0.8877459040000684 23.460452277676808 -10.344331959647192 8.19200583970694 1.0000016928092368 0.6020354056494446 0.3927316303712177 0.23328164503853266 7.21264393116044e-06 5.772661483082462e-07 0.22587494393782873 0.07529132718417562 4.5255153296318256e-11 10.344331959647192 -0.3979662871597922 HGYIFSSLAGCLMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGYIFSSLAGCLMK 14 0 Q9Y3B2;R4GNH9;R4GMQ7;B1AMU3;B1AMU4;B1AMU7 Q9Y3B2 EXOSC1 Exosome complex component CSL4 0 21671200.0 3340900.0 6121800.0 12208500.0 False True 4576121.01442773 5851318.633914562 9325103.741950016 1.0 1.27866343907129 2.037774725045416 22.12569377367087 -6.953597081595716 0.5178523091020406 0.9868832793544047 2.363307286666239 0.9994541635622131 0.010245740986729484 0.08207272637741629 0.030227648349538574 0.01164720073880435 0.06269018752504846 1.1127636193369311e-07 6.953597081595716 1.3764240073118343 up HGYIFSSLAGCLMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGYIFSSLAGCLMK 14 0 Q9Y3B2;R4GNH9;R4GMQ7;B1AMU3;B1AMU4;B1AMU7 Q9Y3B2 EXOSC1 Exosome complex component CSL4 0 29402300.0 7608400.0 10406700.0 11387200.0 False True 9849223.783985665 9827557.996775484 9314846.442538794 1.0 0.9978002543463974 0.9457442177001053 23.231578599769257 -6.915776014984527 0.8554699050656677 1.001332526391863 0.9381144255096243 0.9929248086433067 0.0021090724682007013 0.10072118573729856 0.11896479576750885 0.0017776476201819076 0.005127629167344477 1.21401481056484e-07 6.915776014984527 -0.06321810088223878 HGYIGEFEIIDDHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGYIGEFEIIDDHR 14 0 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 28716600.0 6369600.0 12052000.0 10295000.0 False True 8350607.283294143 10253888.578328058 9229772.156613227 1.0 1.2279213032615646 1.1052815494123287 22.993449688196947 -10.19551599496486 4.061216239632932 0.9999192872474225 1.1666014263172944 0.7110292642402709 0.05006747022439627 35180875.545449935 4.9394230731036375 29624.396994575465 0.017139426716099845 6.375056014193605e-11 10.19551599496486 0.16668213906987184 HGYIGEFEIIDDHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGYIGEFEIIDDHR 14 0 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 21460100.0 5576700.0 5186400.0 10697000.0 False True 5399670.711031253 7257356.566718699 7895134.796878703 1.0 1.3440368783770995 1.4621511605789854 22.3644399991841 -12.413912204981933 0.1706337395708631 5.002846129275286e-13 1.574497591234041 0.9994990109903851 0.004387986389071269 6.443747070297856 0.1169325052492701 2.3168064546380487 0.09494478899720808 3.8555629211301604e-13 12.413912204981933 1.5744975912335408 HGYIGEFEIIDDHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HGYIGEFEIIDDHR 14 0 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 84455000.0 15410000.0 55246000.0 13799000.0 False True 23378096.62190497 45386919.66103184 11071621.601683453 1.0 1.941429210216579 0.47358952188218306 24.47865413873803 -6.7334712608541745 1.7104409038809318 1.56433398876735 0.47386945887380033 0.5753696496278654 0.3956573150005982 0.3297541769909442 1.8914911262606366 0.18319105400094635 0.4528237076952385 1.8472630322562813e-07 6.7334712608541745 -1.0904645298935496 HGYIGEFEIIDDHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGYIGEFEIIDDHR 14 0 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 30043100.0 6369600.0 15367000.0 8306500.0 False True 8724613.2519677 14688035.128126556 6344675.777737457 1.0 1.6835170458488689 0.7272157050980471 23.056659749719838 -6.714819382109761 1.7778813304198628 1.4181311105185312 0.7291185263999708 0.4879620357503085 0.2878248402862654 0.36550210677255435 2.25486666394347 0.12868721580197573 0.32504734097568266 1.928326714508995e-07 6.714819382109761 -0.6890125841185605 HGYIGEFEIIDDHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGYIGEFEIIDDHR 14 0 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 14964200.0 5576700.0 5495400.0 3892100.0 False True 4637273.139698874 5465795.189448504 4705920.114962874 1.0 1.1786657858595386 1.0148033064251327 22.144845274618376 -10.754985204433032 3.0643530754859603 0.9828304415853303 1.096734545980878 0.31725147497351347 0.06689657726854742 24792796.048528597 29091.948217390396 3003361.3057095986 0.022900477423304172 1.757983504011848e-11 10.754985204433032 0.11390410439554766 HGYIGEFEIIDDHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HGYIGEFEIIDDHR 14 0 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 42777000.0 15410000.0 17335000.0 10032000.0 False True 19948548.776512675 16370292.01131033 8206278.937012532 1.0 0.8206257104067958 0.41137222707019994 24.24978046083048 -6.957390340763422 0.4707808103994443 1.0107279078798148 0.20447078895044482 0.9996608032072439 0.004536894937052156 0.08064697530861496 0.024678986237631154 0.005666926623502463 0.033776046375508094 1.1030867277819618e-07 6.957390340763422 -0.80625711892937 down HGYIK(ub)GIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGYIKGIVK 9 1 P62917;E9PKZ0;E9PKU4;G3V1A1;E9PP36 P62917 RPL8 60S ribosomal protein L8 1 19476410.0 2018300.0 4318710.0 13139400.0 True False 1954230.1712615634 6043193.424775125 9697796.966449283 1.0 3.092365225777837 4.962464048023995 20.89816896876008 -7.230102115994324 0.21733729001056468 5.740064498342879e-14 7.626686832691055 0.9999795585433368 0.007317675063019187 0.0993999203514163 0.011837864730627336 0.09908299909511789 0.2792182851330678 5.887052163719522e-08 7.230102115994324 7.626686832690997 HGYIK(ub)GIVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGYIKGIVK 9 1 P62917;E9PKZ0;E9PKU4;G3V1A1;E9PP36 P62917 RPL8 60S ribosomal protein L8 1 12569610.0 2018300.0 6418900.0 4132410.0 True False 1678305.875850274 6384320.111648102 4996477.824894962 1.0 3.804026550531879 2.9770960685957286 20.678574244194355 -10.184164271548642 5.789539175863463 0.9999547953063082 3.3905613095638656 0.9176477451889494 0.3375929555831126 0.00019698506287316956 2.7759163701619476e-05 0.3268790386501415 0.10895765789749569 6.543886052699388e-11 10.184164271548642 2.3906065142575574 HGYIPGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HGYIPGK 7 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;H0YHL7 Q9ULV4 CORO1C Coronin-1C;Coronin 0 11307500.0 2899900.0 4486100.0 3921500.0 False True 3801796.982671544 3816791.366680835 3515740.797684195 1.0 1.0039440254378744 0.9247576379561605 21.85825006293265 -6.895182726592998 0.9912426319380931 1.003741384629855 0.9172136896648538 0.9840126937510775 0.004606846165461351 0.11503778390909888 0.19810083485658328 0.003514908582690636 0.008942834036310042 1.2729673755412038e-07 6.895182726592998 -0.08652769496500123 HGYIPGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HGYIPGK 7 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;H0YHL7 Q9ULV4 CORO1C Coronin-1C;Coronin 0 5722200.0 1588500.0 1968600.0 2165100.0 False True 1538073.937000937 2754672.2461133795 1597995.3583922682 1.0 1.7909881832369292 1.038958739206108 20.552693426317482 -10.172255818577645 3.91110439339668 0.9997798931853132 1.4149734605881925 0.28875471585446755 0.30701473566470866 216939180.26402342 331024703.2240528 619966.5570579492 0.11235585344077302 6.725803601229946e-11 10.172255818577645 0.41519356740287927 HGYIPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HGYIPGK 7 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;H0YHL7 Q9ULV4 CORO1C Coronin-1C;Coronin 0 9851700.0 2899900.0 3619800.0 3332000.0 False True 3972071.39685084 3459865.266922132 2545050.2246940634 1.0 0.8710481059492541 0.6407362734496274 21.921460124455542 -6.962195836634682 0.40329476359902366 1.0122095025663835 0.491120352483314 0.9998431685118073 0.0018609672196016407 0.07892584960519497 0.018300091524241932 0.0029628498592787393 0.019273192627842706 1.0909482836441573e-07 6.962195836634682 -0.5210891500830696 HGYIPGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HGYIPGK 7 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;H0YHL7 Q9ULV4 CORO1C Coronin-1C;Coronin 0 5218600.0 1588500.0 1909800.0 1720300.0 False True 1320908.13248187 1899511.5283343797 2080006.7762315017 1.0 1.4380345473120564 1.5746793626922049 20.33309870175176 -11.861172267673956 0.197863586591575 1.6458192451652085e-10 1.6764799606445628 0.9994057990811172 0.0059753661629113695 4.914036964128022 0.12264215976703574 2.1257675847254087 0.08767157136902938 1.376663291969726e-12 11.861172267673956 1.676479960479981 HHAAYVNNLNVTEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HHAAYVNNLNVTEEK 15 0 P04179-4;P04179;F5H3C5;F5H4R2;F5GYZ5;P04179-3;P04179-2;G8JLJ2;G5E9P6;F5GXZ9 P04179-4 SOD2 Superoxide dismutase [Mn], mitochondrial 0 7483600.0 1205400.0 1579200.0 4699000.0 False True 1167135.2368026024 2209782.7954192073 3468190.933021689 1.0 1.8933391142169311 2.9715416205947895 20.15454030617108 -6.96861757571703 0.28930419277315056 0.7875655459661922 4.110594996558733 0.9999695028737225 0.004451382120474605 0.07675385524718902 0.010627527982346431 0.018907494283052204 0.09785522485448236 1.074935545745416e-07 6.96861757571703 3.323029450592541 HHAAYVNNLNVTEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HHAAYVNNLNVTEEK 15 0 P04179-4;P04179;F5H3C5;F5H4R2;F5GYZ5;P04179-3;P04179-2;G8JLJ2;G5E9P6;F5GXZ9 P04179-4 SOD2 Superoxide dismutase [Mn], mitochondrial 0 4396800.0 1205400.0 3191400.0 0.0 False True 1002343.5082742523 3174207.2947566966 0.0 1.0 3.166785905783707 0.0 19.934945581605355 -6.722532220410484 1.750133236328292 2.314690571292973 0.0042061932289304774 0.5244134814026559 0.9115238666644464 0.3504503838245324 2.0991200701457813 0.4133239206082356 1.0345477352906425 1.8943829644220868e-07 6.722532220410484 -2.3104843780640425 HHFSFPSIFIYGHTASGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HHFSFPSIFIYGHTASGK 18 0 O43913;O43913-2;G3V0H0 O43913 ORC5 Origin recognition complex subunit 5 0 18665800.0 5101600.0 8134800.0 5429400.0 False True 4242206.439200201 8090976.217768633 6564662.437290769 1.0 1.907256597181078 1.5474641631368673 22.01638339801056 -10.346392955828389 5.500224220525606 0.9998151734547007 1.7273603801589832 0.844942375480058 0.1468846461204181 0.000332989765396467 3.957021545092597e-05 0.14225579737761937 0.04740681568649041 4.504089836545204e-11 10.346392955828389 0.7275452067042825 HHGPQTLYLPVTLSSIPVFQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HHGPQTLYLPVTLSSIPVFQR 21 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 102928700.0 49244000.0 46034700.0 7650000.0 False True 64559360.87957429 39166502.201855175 6858451.383981655 1.0 0.6066742555725474 0.10623480918243688 25.944122960602435 -7.60115720568701 0.4965784466586238 1.016878501232455 2.9065299704952862e-22 0.9964300099578662 0.021853371140032975 0.1178647001925075 0.08058495578493088 0.025676072485284498 0.07277781787785412 2.5052022570961794e-08 7.60115720568701 -1.016878501232455 down HHGPQTLYLPVTLSSIPVFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HHGPQTLYLPVTLSSIPVFQR 21 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 488464200.0 200339000.0 124307000.0 163818200.0 False True 193979348.1050242 173943433.3524415 120909298.97934337 1.0 0.8967110934833389 0.6233101624502868 27.531327824024544 -6.954226362965957 0.5103418898616052 1.005017603758387 0.5030021652423007 0.9994925659512705 0.0035799673866817898 0.08183175161206842 0.029272712102517213 0.004120991973090759 0.022564946326921964 1.1111524214666832e-07 6.954226362965957 -0.5020154385160862 HHGPQTLYLPVTLSSIPVFQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HHGPQTLYLPVTLSSIPVFQR 21 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 266668000.0 84418000.0 91872000.0 90378000.0 False True 128068277.78247748 75476723.80078778 72514748.6859154 1.0 0.589347534828134 0.5662194412349393 26.93233792678907 -13.999999999999993 0.4096934344129811 8.368483388237784 0.5651640387334822 0.9998510217029668 0.0024320772607425304 28.256741234711612 0.21214513397399995 185.7408223123651 0.005764776483538655 1.0000000000000164e-14 13.999999999999993 -7.803319349504302 HHGPQTLYLPVTLSSIPVFQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HHGPQTLYLPVTLSSIPVFQR 21 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 285670700.0 49244000.0 76777700.0 159649000.0 False True 67450837.56906195 73385407.3440985 121943194.27436446 1.0 1.0879836335458433 1.8078825803980352 26.007333022125326 -6.929678456682593 0.7494222088959737 0.988921515581828 1.9544735911358473 0.9964748270272048 0.0214864683408854 0.09280472507569387 0.0784990601257417 0.019538043199604654 0.0652537468420879 1.1757677486868711e-07 6.929678456682593 0.9655520755540193 HHGPQTLYLPVTLSSIPVFQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HHGPQTLYLPVTLSSIPVFQR 21 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 403606000.0 200339000.0 110856000.0 92411000.0 False True 166590755.02252787 110258796.7248067 111733712.83981232 1.0 0.6618542350077982 0.6707077642135826 27.31173309945882 -10.598250637414182 6.416561458050132 1.0008821276970576 0.6662809996106904 0.9994724007639372 0.0036144381628333707 4.572450777482006e-05 2.8628704449159138e-06 0.003508318540334481 0.0011665549008791863 2.5220248566196617e-11 10.598250637414182 -0.3346011280863672 HHGPQTLYLPVTLSSIPVFQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HHGPQTLYLPVTLSSIPVFQR 21 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 222231000.0 84418000.0 81544000.0 56269000.0 False True 109280765.12755683 77006004.71706301 46028619.36869605 1.0 0.7046620201384806 0.4211959837119517 26.70346424888152 -7.023041137608004 0.2208594096842863 1.1323226306816943 2.880523093299595e-10 0.9999921468685428 0.0006622032206609605 0.07227999695504897 0.007285016872119176 0.007952206366284166 0.02781691149550941 9.483286306624138e-08 7.023041137608004 -1.132322630393642 down HHPCPPGQGVQSQGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HHPCPPGQGVQSQGK 15 0 J3KT02;Q9Y5U5-3;Q9Y5U5;Q9Y5U5-2 J3KT02 TNFRSF18 Tumor necrosis factor receptor superfamily member 18 0 5616500.0 1430500.0 2068200.0 2117800.0 False True 1875399.3529817068 1759632.621780458 1898670.3713720741 1.0 0.9382708909346743 1.012408566929155 20.838766409316143 -11.998412514107521 8.93047481349089 0.9688582404130243 0.9778057563037845 0.0 0.03292893629549094 0.0 0.0 0.0 0.009746953708260177 1.0036620101859145e-12 11.998412514107521 0.00894751589076026 HHPCPPGQGVQSQGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HHPCPPGQGVQSQGK 15 0 J3KT02;Q9Y5U5-3;Q9Y5U5;Q9Y5U5-2 J3KT02 TNFRSF18 Tumor necrosis factor receptor superfamily member 18 0 4013080.0 915480.0 2211900.0 885700.0 False True 1388850.0905529906 1817169.16334642 710641.0067839001 1.0 1.3083983474579954 0.5116758184470062 20.405459455693578 -6.80173510581888 1.4487123292977067 1.1697823712772557 0.5001862446129417 0.8372286653778955 0.13233689280865613 0.21828175868153296 0.9042413921022632 0.07185572040094683 0.16694436096056042 1.5785738136321306e-07 6.80173510581888 -0.669596126664314 HHPCPPGQGVQSQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HHPCPPGQGVQSQGK 15 0 J3KT02;Q9Y5U5-3;Q9Y5U5;Q9Y5U5-2 J3KT02 TNFRSF18 Tumor necrosis factor receptor superfamily member 18 0 6436700.0 1430500.0 2404100.0 2602100.0 False True 1959394.5078089368 2297878.9127044347 1987537.5719316998 1.0 1.1727494915120504 1.0143631433132032 20.901976470839035 -10.75899380585297 2.5591570361340117 0.9773937104311176 1.0935563174373781 0.31750410627834447 0.0646609600316374 17593540.567080136 12747692.541132625 2503428.6938297004 0.02369885476160212 1.7418317161774663e-11 10.75899380585297 0.11616260700626058 HHPCPPGQGVQSQGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HHPCPPGQGVQSQGK 15 0 J3KT02;Q9Y5U5-3;Q9Y5U5;Q9Y5U5-2 J3KT02 TNFRSF18 Tumor necrosis factor receptor superfamily member 18 0 1946750.0 915480.0 506730.0 524540.0 False True 1185106.9068086855 478530.03004853055 429079.10223490366 1.0 0.4037863818861202 0.3620594055859054 20.176585777786027 -13.999999999999975 0.37763470097714713 9.714367194565646 0.35824065937528377 0.9998036789405309 0.004082813999657303 23.73923585353113 0.2001789127362697 168.01499548263433 0.011390827214852912 1.0000000000000573e-14 13.999999999999975 -9.356126535190363 HHPDLIFCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HHPDLIFCR 9 0 Q7RTV0 Q7RTV0 PHF5A PHD finger-like domain-containing protein 5A 0 4708800.0 1581900.0 1930100.0 1196800.0 False True 2073886.2191413895 1642136.603470873 1072966.616516242 1.0 0.7918161509124327 0.5173700498190597 20.983905314206584 -6.967314375674444 0.31582237158914195 1.039476331117834 0.2609118787763489 0.9999532094809255 0.0013519907869669764 0.07718416419905043 0.012135252108362254 0.0042328311347938526 0.024232021750101942 1.0781659804067251e-07 6.967314375674444 -0.7785644523414852 HHPDLIFCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HHPDLIFCR 9 0 Q7RTV0 Q7RTV0 PHF5A PHD finger-like domain-containing protein 5A 0 11665400.0 1951700.0 7420100.0 2293600.0 False True 2960871.58838235 6095925.181494084 1840268.9546794074 1.0 2.058827949652672 0.6215294718960861 21.49759049218641 -6.7092903589662 1.7974693883354098 1.6514037857652348 0.6249353004315948 0.46185661577519355 0.44623314892938104 0.376499702817925 2.370726112965937 0.19758165523771326 0.5024325186484359 1.9530332675672518e-07 6.7092903589662 -1.0264684853336399 HHPDLIFCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HHPDLIFCR 9 0 Q7RTV0 Q7RTV0 PHF5A PHD finger-like domain-containing protein 5A 0 4829900.0 1581900.0 1803300.0 1444700.0 False True 2166771.179240092 1723624.243284351 1103491.614530465 1.0 0.7954805102626678 0.5092792562052955 21.047115375729476 -6.966385403343173 0.33342065154417905 1.0335065675680084 0.261835879309095 0.9999389198035163 0.0015729044346769892 0.07749393003724789 0.013219193728091806 0.004126754215337665 0.024895481973426923 1.0804746865631733e-07 6.966385403343173 -0.7716706882589134 HHSLGGQYGVQGFPTIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HHSLGGQYGVQGFPTIK 17 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 261528000.0 96690000.0 130703000.0 34135000.0 False True 126761526.34729186 111202621.87630375 30603037.64604103 1.0 0.8772584638310447 0.2414221296310135 26.917541695661022 -6.939018073360402 0.6686351781167589 1.007272470551857 0.07479880890953154 0.9980324520397305 0.01474714301320401 0.08821744377631291 0.056670926140659494 0.014250618472913182 0.054966149112068596 1.1507524988646015e-07 6.939018073360402 -0.9324736616423255 down HHSLGGQYGVQGFPTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HHSLGGQYGVQGFPTIK 17 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 86000000.0 24630000.0 14288000.0 47082000.0 False True 23848134.131780367 19993272.910935678 34749811.77027604 1.0 0.8383579528887484 1.4571291648334006 24.507373058990314 -6.837329168774719 1.2949478259086804 0.9139621667023413 1.476402102648089 0.9197249578329392 0.07424270361819835 0.17194650826170493 0.5612780303284 0.044977545333684685 0.10354553420760487 1.4543563491707593e-07 6.837329168774719 0.5624399359457476 HHSLGGQYGVQGFPTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HHSLGGQYGVQGFPTIK 17 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 146263000.0 96690000.0 25903000.0 23670000.0 False True 132438905.94900094 24758519.81023375 18079633.498952124 1.0 0.18694295028205432 0.13651300854081475 26.980751757183913 -13.54324757237763 0.39968235244265815 9.999910955229273 0.13346615033538461 0.9998281747051667 0.0051869326885292995 18.30910198729913 0.20773143160835608 140.85843140819244 0.012919160505807995 2.862545692024059e-14 13.54324757237763 -9.866444804893888 HHSLGGQYGVQGFPTIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HHSLGGQYGVQGFPTIK 17 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 49280300.0 24630000.0 15080000.0 9570300.0 False True 20480936.294005975 14998761.046854366 11571405.481932424 1.0 0.7323278990543004 0.5649842036430216 24.28777833442459 -9.444208963717758 0.09016660872295897 1.7237634157130037 1.2950448037549427e-09 0.9999664719644653 0.0010373924591528852 0.9070362634744759 0.034855588435738334 0.4068359616452215 0.25141408364774026 3.595762809743188e-10 9.444208963717758 -1.723763414417959 HHSLGGQYGVQGFPTIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HHSLGGQYGVQGFPTIK 17 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 104381000.0 48615000.0 21712000.0 34054000.0 False True 62933075.844916604 20503708.113618072 27856521.42354714 1.0 0.32580177972143803 0.4426372150026931 25.907315120354692 -9.973256422586743 5.907216741223252 1.0000005299429129 0.38421949736662475 0.9737101409851726 0.047697866719728185 3.3287084322283523e-07 5.790004860803653e-08 0.04618330008758149 0.015394420287846284 1.0635148965774808e-10 9.973256422586743 -0.6157810325762881 HHVLGTITTDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HHVLGTITTDK 11 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 7236300.0 1641200.0 2403300.0 3191800.0 False True 2151629.0934034097 2044737.0079900287 2861543.1539075375 1.0 0.9503203940952941 1.3299425828924807 21.036997970998133 -6.873966923292717 1.1128423702260064 0.9710991436973642 1.353923193236952 0.9684870724450341 0.029906822067619545 0.13311093995335502 0.3056936779318212 0.02080147550340196 0.049619102524021665 1.336697318121428e-07 6.873966923292717 0.3828240495395878 HHVLGTITTDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HHVLGTITTDK 11 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 3147800.0 1641200.0 1506600.0 0.0 False True 2247995.9917623396 1440033.430340045 0.0 1.0 0.6405854083445744 0.0 21.100208032521024 -7.5554584498627415 0.6938505988468101 0.9948906773159278 3.321063611789548e-15 0.9870655075327577 0.04703783308540947 0.12063330240512375 0.14464191998089448 0.04207171402180422 0.07652324448219092 2.78318163569129e-08 7.5554584498627415 -0.9948906773159245 down HIADLAGNSEVILPVPAFNVINGGSHAGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HIADLAGNSEVILPVPAFNVINGGSHAGNK 30 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 0 199992800.0 90042100.0 85568700.0 24382000.0 False True 118046065.0689369 72802183.50418016 21859184.528658945 1.0 0.6167268977721954 0.18517503752364428 26.814774710871752 -7.551735311271206 0.3968712810032615 1.040942382719843 6.892094713185969e-24 0.9988020231403313 0.011520380374973263 0.12070007012559786 0.05150188158244798 0.0215615262886291 0.06922138999141209 2.807143982028611e-08 7.551735311271206 -1.040942382719843 down HIADLAGNSEVILPVPAFNVINGGSHAGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HIADLAGNSEVILPVPAFNVINGGSHAGNK 30 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 0 752222500.0 310992000.0 190690000.0 250540500.0 False True 301119729.1884143 266833511.43521306 184916426.9961099 1.0 0.8861375910319449 0.6140960191964222 28.165761994792906 -6.9564257856503495 0.48318294615897445 1.0063381313262676 0.48249219582617303 0.9996137981864597 0.0031815799959705633 0.08100354884804248 0.026043710878602123 0.00386081549171693 0.022439003568208778 1.1055393731776786e-07 6.9564257856503495 -0.5238459355000946 HIADLAGNSEVILPVPAFNVINGGSHAGNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HIADLAGNSEVILPVPAFNVINGGSHAGNK 30 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 0 1678419000.0 443884000.0 957260000.0 277275000.0 False True 673404480.2672079 786429473.893483 222471474.71605042 1.0 1.1678411666958715 0.33036827231647375 29.32689807877616 -6.854593992115305 1.2127986178018106 1.090048776235769 0.2938179567379106 0.9467139143435459 0.08351161811128673 0.15247957977553933 0.4292991626768663 0.053812481416901446 0.12494135235376239 1.3976743911256373e-07 6.854593992115305 -0.7962308194978582 down HIADLAGNSEVILPVPAFNVINGGSHAGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HIADLAGNSEVILPVPAFNVINGGSHAGNK 30 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 0 262961600.0 90042100.0 39279100.0 133640400.0 False True 123333097.66625875 37543619.48338614 102077289.93043345 1.0 0.3044083072086598 0.8276552836340506 26.877984772394644 -10.029341046046977 6.854489097637084 1.000000096402145 0.5660317954217973 0.47839282694991936 0.2136146836160532 3.146767107279068e-07 4.451405442270469e-08 0.20683157426755172 0.06894384267919473 9.346714000691287e-11 10.029341046046977 -0.43396830098034767 HIADLAGNSEVILPVPAFNVINGGSHAGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HIADLAGNSEVILPVPAFNVINGGSHAGNK 30 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 0 693178100.0 310992000.0 213163100.0 169023000.0 False True 258603627.28158784 212014748.0707376 204364927.825947 1.0 0.8198444480435666 0.7902631914881011 27.946167270227182 -13.999999999295175 0.2542379462920434 2.2801524933212898 0.7788394851567194 0.9995508112787236 0.0019644406241774103 14.169943695352906 0.15954900199039765 9.287377826667914 0.013337237266943787 1.0000000016229186e-14 13.999999999295175 -1.5013130081645705 HIADLAGNSEVILPVPAFNVINGGSHAGNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HIADLAGNSEVILPVPAFNVINGGSHAGNK 30 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 0 1070029000.0 443884000.0 369715000.0 256430000.0 False True 574616588.2617494 349140035.2443955 209762371.193992 1.0 0.6076052142883059 0.36504753861794365 29.09802440086861 -8.70994796919602 0.1666356431780531 1.4148536945353622 5.02804079607437e-14 0.9998205240235701 0.0035047898956025777 0.2654103364490854 0.04682232330351179 0.2029734025293589 0.14840312163851815 1.9500782155737544e-09 8.70994796919602 -1.414853694535312 down HIANYISGIQTIGHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HIANYISGIQTIGHR 15 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 64871000.0 17230000.0 15596000.0 32045000.0 False True 22588696.855557367 13269137.592731863 28729290.79734538 1.0 0.5874237755980746 1.2718436561902542 24.42909770810527 -6.743480117194453 1.6738253395759275 0.7555110933109186 1.27256678830313 0.6204851208656629 0.17334065008684588 0.311570866547526 1.715241182838372 0.08188052767625194 0.20017511255281023 1.805177379602803e-07 6.743480117194453 0.5170556949922114 HIANYISGIQTIGHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HIANYISGIQTIGHR 15 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 64674400.0 14127000.0 9689400.0 40858000.0 False True 13678546.117728842 13558427.94955347 30156064.086273715 1.0 0.9912184988710395 2.204624952588219 23.705411559624675 -6.905269807537286 0.927355953340362 0.9565826170818995 2.3465468264882783 0.989010498407499 0.059747986288736725 0.10762942297815396 0.15635333281769367 0.04780009381672203 0.12799990812482004 1.2437416911937352e-07 6.905269807537286 1.3899642094063789 up HIANYISGIQTIGHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HIANYISGIQTIGHR 15 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 72290000.0 24992000.0 30121000.0 17177000.0 False True 37914691.159938335 24745672.213552866 13781958.42105345 1.0 0.6526671181143576 0.3634991608639511 25.176253635477863 -7.526572960138073 0.22222859226868694 1.1687203280092422 1.0325635032329112e-14 0.9999146525791887 0.0024039249766958687 0.12908643010152607 0.02208426590042518 0.031332845746594486 0.06762127876195005 2.9745894950104595e-08 7.526572960138073 -1.1687203280092318 down HIANYISGIQTIGHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HIANYISGIQTIGHR 15 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 68680000.0 17230000.0 24018000.0 27432000.0 False True 23600396.62324221 22956805.343095165 20953126.57977418 1.0 0.9727296413521618 0.8878294256774931 24.492307769628162 -6.950615278164078 0.5520563032002491 1.0011600876457887 0.8553964608067245 0.9992486145523232 0.0013093092567316468 0.08323978031506124 0.03494838649337191 0.0014173679870695276 0.007045954963605052 1.1204299822124281e-07 6.950615278164078 -0.1457636268390642 HIANYISGIQTIGHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HIANYISGIQTIGHR 15 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 46535000.0 14127000.0 19867000.0 12541000.0 False True 11747226.432213662 19759972.527709264 15163265.11696754 1.0 1.6820968457305603 1.2907953383265258 23.48581683505895 -10.264530887583273 4.81415878757213 0.9998599220981023 1.4864460920292661 0.6732623419677133 0.1597481714561201 0.00024024365773883468 3.670247824194793e-05 0.15471966098595605 0.051558500636032595 5.438374519244653e-11 10.264530887583273 0.4865861699311639 HIANYISGIQTIGHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HIANYISGIQTIGHR 15 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 92493000.0 24992000.0 33383000.0 34118000.0 False True 32352636.6659705 31525206.70398458 27908874.080242574 1.0 0.9744246513652398 0.862646045464294 24.947379957570313 -6.9428485691744495 0.6325459862524331 1.001219646708771 0.8298008529087019 0.998513271601331 0.002299681393891521 0.08649169933133893 0.048877196675178376 0.002290143431485501 0.009506478648678075 1.1406474418733258e-07 6.9428485691744495 -0.1714187938000692 HIAVFPCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HIAVFPCK 8 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 12674600.0 3188600.0 6484600.0 3001400.0 False True 4837339.317884894 5327372.465588944 2408171.9744396494 1.0 1.1013022067507794 0.49782986393698186 22.20578230931183 -6.8637425292452585 1.1667830410400235 1.055604550679552 0.4664625190158274 0.9580204786376237 0.054062754917590126 0.14299423857955745 0.3678236013798356 0.03608167475851574 0.08460685266182938 1.3685399217394498e-07 6.8637425292452585 -0.5891420316637246 down HIDCAAIYGNEPEIGEALK(ub)EDVGPGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HIDCAAIYGNEPEIGEALKEDVGPGK 26 1 P14550;Q5T621;V9GYG2;V9GYP9 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 1 68089900.0 8271900.0 10488000.0 49330000.0 True False 12549077.056893956 8616334.456881976 39579903.87789293 1.0 0.6866110087473333 3.154009151306416 23.581077926841324 -6.875019369739111 1.1071582820645822 0.816038141110757 3.3130218782407153 0.9694430003130322 0.19172049699855387 0.1321354376367613 0.29970161470441387 0.13393315990850063 0.32017309745868117 1.333461957803619e-07 6.875019369739111 2.496983737129958 up HIDCAAIYGNEPEIGEALK(ub)EDVGPGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HIDCAAIYGNEPEIGEALKEDVGPGK 26 1 P14550;Q5T621;V9GYG2;V9GYP9 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 1 58960800.0 8271900.0 8922900.0 41766000.0 True False 10708137.61352598 8426332.771140521 34165016.55534942 1.0 0.7869092717389813 3.190565697642314 23.352204248933774 -6.885285056427187 1.049907944249732 0.8558760182132651 3.379144439589021 0.9777034467176585 0.16221520481620905 0.1230505348121061 0.24488155911484052 0.11839598275906273 0.2905637244708108 1.3023117038525034e-07 6.885285056427187 2.523268421375756 up HIDCAHVYQNENEVGVAIQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HIDCAHVYQNENEVGVAIQEK 21 0 P15121;E9PCX2;E9PEF9 P15121 AKR1B1 Aldose reductase 0 14111000.0 2664100.0 7448800.0 3998100.0 False True 3492660.8991810987 6337468.07519499 3584414.9644832714 1.0 1.8145099848315922 1.0262705335418292 21.735895148267073 -10.212413249761358 4.014502898674776 0.9997285142267972 1.420390259034782 0.27496924255987665 0.3217974088614756 75497305.50648227 106.1591149359915 202136.08874184222 0.1101598123025629 6.131782621568333e-11 10.212413249761358 0.4206617448079849 HIDCAHVYQNENEVGVAIQEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HIDCAHVYQNENEVGVAIQEK 21 0 P15121;E9PCX2;E9PEF9 P15121 AKR1B1 Aldose reductase 0 76805900.0 14931900.0 46358000.0 15516000.0 False True 22652783.96811314 38085052.703292795 12449255.7990956 1.0 1.6812526335351392 0.549568468785983 24.433185028839652 -6.743694050401211 1.6730570745365487 1.4035984398789099 0.5483414649033713 0.6214467348560943 0.2862223767482179 0.3111782587269102 1.711586618182472 0.13526083983692952 0.3305963658925799 1.8042883692666145e-07 6.743694050401211 -0.8552569749755385 HIDCAHVYQNENEVGVAIQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HIDCAHVYQNENEVGVAIQEK 21 0 P15121;E9PCX2;E9PEF9 P15121 AKR1B1 Aldose reductase 0 15282100.0 2664100.0 4920000.0 7698000.0 False True 3649089.7645954452 4702618.1317357095 5879890.945286585 1.0 1.2887099071560009 1.6113308590912279 21.799105209789964 -6.969688398136846 0.26552108486727766 0.9153167157086374 1.9943654399005808 0.99997984958769 0.0011208810033658447 0.07640393793910111 0.009391229263480108 0.006502140248212002 0.030194662890363537 1.0722883852855803e-07 6.969688398136846 1.0790487241919435 HIDCAHVYQNENEVGVAIQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HIDCAHVYQNENEVGVAIQEK 21 0 P15121;E9PCX2;E9PEF9 P15121 AKR1B1 Aldose reductase 0 43363900.0 14931900.0 18234000.0 10198000.0 False True 19329638.90175277 17219261.871025812 8342068.640316383 1.0 0.8908217043549844 0.43156877801581395 24.2043113509321 -6.943720167290315 0.6239974206202281 1.005015418148812 0.2928773735025261 0.9986116642861578 0.009177010543248718 0.08610977927154548 0.04718411693675184 0.009208532360776957 0.03892609546499113 1.1383605392318893e-07 6.943720167290315 -0.7121380446462859 down HIDFSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HIDFSLR 7 0 P46781 P46781 RPS9 40S ribosomal protein S9 0 116921000.0 37876000.0 36890000.0 42155000.0 False True 49655802.79170574 31386155.796093747 37793204.97931325 1.0 0.6320742799739074 0.7611034935402562 25.56545898558333 -10.349941983053085 5.319884001681063 1.0001056316145465 0.6965888876630593 0.8805639812564734 0.05267595585839765 6.601842520505718e-05 8.067004359793557e-06 0.0510209459222127 0.017001091648755278 4.4674326813213243e-11 10.349941983053085 -0.3035167439514872 HIDFSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HIDFSLR 7 0 P46781 P46781 RPS9 40S ribosomal protein S9 0 92715000.0 29186000.0 15049000.0 48480000.0 False True 28259506.405608706 21058144.179498248 35781633.631175056 1.0 0.745170275703004 1.2661804179309168 24.75223293128468 -6.773709972665535 1.5602820028792295 0.854530737531558 1.2695290169471605 0.7445429364243232 0.10751371329054592 0.2604695674226142 1.2519148716902266 0.05429809150766194 0.1288156357343079 1.6837981473363e-07 6.773709972665535 0.4149982794156025 HIDFSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HIDFSLR 7 0 P46781 P46781 RPS9 40S ribosomal protein S9 0 449249000.0 92679000.0 228280000.0 128290000.0 False True 140600818.7424747 187541650.44021916 102933425.26849556 1.0 1.333858878757467 0.7320969123019763 27.06702975459234 -6.756091837967139 1.6269572867414501 1.1948615843731938 0.730296262338676 0.6748956688341252 0.14035513005743194 0.2895353024248269 1.5095065097618998 0.06809399693474524 0.16429290880091185 1.7535096571794536e-07 6.756091837967139 -0.46456532203451784 HIDFSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HIDFSLR 7 0 P46781 P46781 RPS9 40S ribosomal protein S9 0 269172000.0 37876000.0 48226000.0 183070000.0 False True 51879780.76041329 46095215.85794429 139832636.4450007 1.0 0.8885005908335893 2.6953204966451896 25.62866904710622 -6.89220809038512 1.0092072435412016 0.9079941142869953 2.857630014683742 0.9822751127962467 0.11006477670637145 0.11737071189814845 0.21151860739966244 0.08284694728662036 0.2082546328488938 1.281716306494737e-07 6.89220809038512 1.9496359003967467 up HIDFSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HIDFSLR 7 0 P46781 P46781 RPS9 40S ribosomal protein S9 0 79156000.0 29186000.0 19791000.0 30179000.0 False True 24269452.15902797 19684381.954794057 36489289.3680698 1.0 0.8110764851967077 1.5035069242177426 24.532638206718957 -6.834006380081378 1.3099511925115734 0.8992986052965664 1.5237066097686267 0.9136459386511895 0.08587968475585994 0.17591847984501333 0.5889548114374451 0.05145244430987217 0.11841201603729103 1.4655263112192974e-07 6.834006380081378 0.6244080044720604 HIDFSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HIDFSLR 7 0 P46781 P46781 RPS9 40S ribosomal protein S9 0 375529000.0 92679000.0 177610000.0 105240000.0 False True 119974792.4762117 167725847.36826202 86087399.85358837 1.0 1.3980090642917202 0.7175457283717125 26.83815607668479 -6.748199479926775 1.656861413274409 1.2345418627842917 0.7164053164232634 0.6410569793498709 0.16723195345220315 0.30318855547947804 1.6370653248457847 0.07975801139843028 0.1939715798896171 1.785667194684881e-07 6.748199479926775 -0.5181365463610282 HIDLQFSYAPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HIDLQFSYAPR 11 0 H3BQQ2;H3BPG6;Q86UK7-2;Q86UK7-3;Q86UK7 H3BQQ2 ZNF598 Zinc finger protein 598 0 9101200.0 2843400.0 2613600.0 3644200.0 False True 4313645.680384468 2147182.659849993 2923922.2726903963 1.0 0.4977651895736179 0.6778308858296845 22.04047624880228 -10.210897309139002 4.929815561644797 1.000053085821824 0.5877980377010393 0.8747980906460582 0.07351151266984655 4.289658842390974e-05 6.866276730916455e-06 0.0711863567639031 0.023725738693432998 6.153223512151673e-11 10.210897309139002 -0.4122550481207846 HIDQLK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 HIDQLKER 8 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 12034200.0 2577300.0 4052000.0 5404900.0 True False 3378865.258608707 3447457.3945722943 4845652.795461755 1.0 1.0203003466293388 1.4341065489711233 21.68810738960603 -6.9171074908371395 0.8459056766089721 0.9898835778829375 1.4965895625687522 0.9933389206807699 0.016325266283683245 0.09990366822404324 0.11465521975095139 0.013854555109235004 0.040419497166848686 1.2102985393586215e-07 6.9171074908371395 0.5067059846858147 HIDQLK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 HIDQLKER 8 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 13058300.0 2086400.0 3895600.0 7076300.0 True False 2020168.37403762 5451133.395285631 5222804.745550407 1.0 2.6983559713840557 2.5853314073578044 20.946044110947707 -10.159968317058507 4.79790307488026 0.999846911977391 2.641843689379366 0.9964583756283252 0.0461420850731793 7.556671368730946e-05 1.3230445015493724e-05 0.044680915292633946 0.014892293916515854 6.918814436756517e-11 10.159968317058507 1.6419967774019752 HIDQLK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HIDQLKER 8 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 11442100.0 2577300.0 2843600.0 6021200.0 True False 3530197.458913649 2717960.3494722885 4599116.570506567 1.0 0.7699173717916303 1.3027930091825113 21.751317451128923 -6.7893482391348 1.4987872858746716 0.8712979847110245 1.3083710067528789 0.7992527815765678 0.09777289707129719 0.23632312771595843 1.048737102677069 0.051347640907879695 0.12028241244605054 1.6242458315344563e-07 6.7893482391348 0.4370730220418544 HIDQLK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HIDQLKER 8 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 10999400.0 2086400.0 3246200.0 5666800.0 True False 1734934.043191802 3228712.0762797515 6851701.679677191 1.0 1.86099989734469 3.9492577291710425 20.726449386381983 -6.95610820962832 0.487202187476523 0.9531197616486818 4.945269418490204 0.9995974960159828 0.024843198123140547 0.08112188910978813 0.026500290545645802 0.02988728179258314 0.17223549880286554 1.1063480898660765e-07 6.95610820962832 3.992149656841522 HIEIFTDLSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HIEIFTDLSSR 11 0 P13010;C9JZ81 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 41690000.0 11408000.0 19393000.0 10889000.0 False True 14767880.885298943 18313762.50218294 8907313.730575118 1.0 1.2401076799321853 0.6031544945248121 23.81595948587222 -6.8045756848787935 1.437062604401247 1.1317224334656608 0.5933271702542149 0.8452142078783725 0.10333245077252427 0.2143004792694107 0.8731715026552539 0.05655402140467947 0.13118042482123468 1.5682825678909977e-07 6.8045756848787935 -0.5383952632114459 HIEQK(ub)QVEDFAMIPAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HIEQKQVEDFAMIPAK 16 1 E9PHH9;Q9BUI4 E9PHH9 POLR3C DNA-directed RNA polymerase III subunit RPC3 1 6043200.0 1076900.0 2370500.0 2595800.0 True False 1042714.398965257 3317053.011994197 1915882.1076692308 1.0 3.1811711963370715 1.8373987254520185 19.99191262495762 -10.336355790921925 6.017437143344673 0.9998467735121167 2.5092849608945462 0.6271459441592511 0.5485928140112294 0.001127818879212317 0.00012438530400066806 0.5312242158695568 0.17705756937621192 4.609398000353969e-11 10.336355790921925 1.5094381873824294 HIEQK(ub)QVEDFAMIPAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HIEQKQVEDFAMIPAK 16 1 E9PHH9;Q9BUI4 E9PHH9 POLR3C DNA-directed RNA polymerase III subunit RPC3 1 5730000.0 1076900.0 2274800.0 2378300.0 True False 895490.0647590351 2262545.2008875515 2875591.533983247 1.0 2.5266000036486984 3.2111931188840512 19.772317900391897 -9.331259215766247 0.25074828879874284 4.594836505622325e-16 3.6450089568487174 0.9990981130550117 0.02775728703914919 0.7434899864301223 0.09540487841030884 0.9100155524772511 0.29501770933871285 4.663809301359989e-10 9.331259215766247 3.645008956848717 HIFVFQASHPLSWGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HIFVFQASHPLSWGR 15 0 P48651;P48651-3;P48651-2 P48651 PTDSS1 Phosphatidylserine synthase 1 0 11327600.0 2901100.0 4017700.0 4408800.0 False True 3803370.194292368 3418274.8208719417 3952619.668195862 1.0 0.8987489111634912 1.039241374433514 21.858846937290096 -6.713339935172243 1.783358910563329 0.9379655412574953 1.0389437262030106 0.48088678846722566 0.04264522371695586 0.36842008873202464 2.286061928190147 0.019015331632602415 0.04811216551941818 1.9349068620757206e-07 6.713339935172243 0.10097818494551525 HIFVFQASHPLSWGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HIFVFQASHPLSWGR 15 0 P48651;P48651-3;P48651-2 P48651 PTDSS1 Phosphatidylserine synthase 1 0 8707300.0 2901100.0 3064200.0 2742000.0 False True 3973715.069279629 2928813.5120456438 2094396.073262641 1.0 0.7370466832632242 0.5270624684326755 21.922056998812987 -6.973669247093348 0.14598398973460688 1.2582836518797205 0.0003214336081410058 0.9999987075860961 0.00021987982319175716 0.07512912696927129 0.004445230383448501 0.011159042338517788 0.026637343924474064 1.062504438405111e-07 6.973669247093348 -1.2579622182715795 HIGLVYSGMGPDYR ddPTM_RPMI8226_Bortezomib_1h_R1 2 HIGLVYSGMGPDYR 14 0 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 105064200.0 32076000.0 39726000.0 33262200.0 False True 42051946.624425866 33799035.650735155 29820546.617552225 1.0 0.8037448528269318 0.7091359380788086 25.325669249957194 -13.999999921143669 0.09635762484749552 1.9804801847365683 0.49574746325986363 0.9998118124274679 0.0016617732486312075 12.1091438027753 0.09168637644761285 2.3841515582486714 0.1907531732948331 1.0000001815734293e-14 13.999999921143669 -1.4847327214767048 HIGLVYSGMGPDYR ddPTM_RPMI8226_Bortezomib_2h_R1 2 HIGLVYSGMGPDYR 14 0 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 65452800.0 22444300.0 14619200.0 28389300.0 False True 21731817.98188867 20456722.798120867 20953290.669255715 1.0 0.9413258851684443 0.9641756932953433 24.373305532874628 -10.157655463473535 4.469431536676928 1.0000081206972715 0.952750789230602 0.8507719128963307 0.009328395109618087 7.549719713870185e-07 1.4227467731597681e-07 0.009033732019874612 0.0030107265749179323 6.955759162955729e-11 10.157655463473535 -0.04725733146666955 HIGLVYSGMGPDYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HIGLVYSGMGPDYR 14 0 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 32456800.0 15174000.0 10065000.0 7217800.0 False True 23020067.367993902 8268822.111796071 5791198.666325875 1.0 0.3592006043949585 0.2515717514527218 24.456388719720277 -13.999999999999998 0.25101682748802306 5.479399134651488 0.20871254437881917 0.9995446089626491 0.0070502506298746204 14.038550255325754 0.15853750969123823 31.72723662332089 0.04939097207567873 1.0000000000000041e-14 13.999999999999998 -5.2706865902726685 HIGLVYSGMGPDYR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 HIGLVYSGMGPDYR 14 0 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 103284000.0 32076000.0 34313000.0 36895000.0 False True 43935364.021306835 32796938.202082805 28181160.876376785 1.0 0.7464815401592586 0.6414231793484194 25.388879311480085 -13.999999999999995 0.12091056847405858 2.2075424808109614 0.4757826474803659 0.9996884846842601 0.0026565093137862323 11.960385251044375 0.1071314903515895 3.4663186434687883 0.14699818537953482 1.0000000000000123e-14 13.999999999999995 -1.7317598333305955 HIGLVYSGMGPDYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HIGLVYSGMGPDYR 14 0 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 15247700.0 5550300.0 5444800.0 4252600.0 False True 4615320.36998057 5415467.781691817 5141798.998199199 1.0 1.1733676857874582 1.1140719573104838 22.137999364571236 -10.098404148188141 4.364951886259298 0.999983323957471 1.1437198215610116 0.8867875113122995 0.024207379823183987 16847765.9003812 0.456651245687034 2823.783166053149 0.008286829986015872 7.972524303287882e-11 10.098404148188141 0.14373649760354057 HIGLVYSGMGPDYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HIGLVYSGMGPDYR 14 0 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 40595000.0 15174000.0 14312000.0 11109000.0 False True 19643042.124257192 13515524.618740885 9087275.987965738 1.0 0.6880565919089775 0.46262060278045536 24.227515041812726 -7.7427761442990475 0.15213916116856374 1.319284489414442 3.980144856786028e-14 0.9999688905234756 0.0012288946467403548 0.13249313951962322 0.019405754880129345 0.062168347471018036 0.09066318673109508 1.80810586824236e-08 7.7427761442990475 -1.3192844894144022 down HIGTSALMDLLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HIGTSALMDLLLR 13 0 O75170-6;O75170-2;O75170-4;O75170-3;O75170-5;O75170 O75170-6 PPP6R2 Serine/threonine-protein phosphatase 6 regulatory subunit 2 0 3776570.0 383890.0 914880.0 2477800.0 False True 525824.5072371706 874457.5764964153 1892594.6718928416 1.0 1.66302172010023 3.599289583966074 19.004221858016173 -6.952054527219642 0.5358214799401906 0.9706828945784998 4.380406414979541 0.9993527630906116 0.028055563657554173 0.08267124075812 0.032629153018759946 0.031038122208165216 0.16024758041657167 1.116723030422875e-07 6.952054527219642 3.4097235204010414 HIHITQATETTTTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HIHITQATETTTTR 14 0 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 0 4196930.0 367630.0 2299400.0 1529900.0 False True 481966.490133984 1956338.4829909983 1371600.6238370624 1.0 4.059075730445797 2.8458422979899805 18.878573317576453 -9.081951560098808 11.976209800965872 0.9999991604169252 3.45245901421792 0.8449181040298239 0.4953004747340394 0.0 6.924895842093904e-18 0.4795726225032336 0.15985754083441114 8.280345150430026e-10 9.081951560098808 2.4524598538009945 HIHITQATETTTTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HIHITQATETTTTR 14 0 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 0 4164680.0 993390.0 866690.0 2304600.0 False True 961855.3782041944 1212763.8367286427 1700956.123481974 1.0 1.2608588195378188 1.7684115117780985 19.875460465279875 -6.960579598064039 0.42718649777278533 0.9792271799723751 2.069416872939012 0.9997910956145272 0.004611336131143595 0.07949472325006912 0.020371060395806485 0.0066013467268024135 0.042170847347120254 1.0950158410296609e-07 6.960579598064039 1.090189692966637 HIHITQATETTTTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HIHITQATETTTTR 14 0 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 0 9862100.0 1561000.0 6516400.0 1784700.0 False True 2368151.1243863553 5353497.507134419 1431953.262738203 1.0 2.260623256685799 0.6046714029322163 21.175329719313794 -6.70316193258344 1.8192704225062768 1.7803354174611994 0.6092356922677495 0.43277510385092377 0.531820430158398 0.3889627755825473 2.5048832622281014 0.23300401202105547 0.5969688718634357 1.9807883243244733e-07 6.70316193258344 -1.1710997251934498 HIHITQATETTTTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HIHITQATETTTTR 14 0 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 0 4090030.0 367630.0 1972000.0 1750400.0 False True 503552.7458271923 1884870.519468049 1336991.5706195934 1.0 3.743144159350673 2.6551172279346837 18.941783379099345 -10.405175543853112 6.271990844738061 0.9995911937782064 3.1991306936426787 0.8448903482100758 0.4441851347292211 0.002539535472860035 0.00024084283669897116 0.4301452242973185 0.1433601357865975 3.9339103282664517e-11 10.405175543853112 2.199539499864472 HIHITQATETTTTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HIHITQATETTTTR 14 0 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 0 3200910.0 993390.0 2207520.0 0.0 False True 826047.7996387576 2195627.651601589 0.0 1.0 2.6579910418764725 0.0 19.65586574071415 -6.738381743135301 1.6950650459470689 1.9887074496961454 2.5584797566983515e-06 0.596064708550685 0.6966663415762081 0.3210559323873863 1.811095138658972 0.32537356048563837 0.7991071816469866 1.8264940292881865e-07 6.738381743135301 -1.9887048912163887 HIHITQATETTTTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HIHITQATETTTTR 14 0 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 0 7281000.0 1561000.0 3619900.0 2100100.0 False True 2020745.271910211 3418449.3828521604 1717903.348845698 1.0 1.691677536189754 0.8501335486098965 20.946456041406243 -6.68829283228059 1.8722429828315594 1.4343208808435353 0.8530798342929257 0.3625702598259135 0.2926316907079526 0.4203387495771728 2.8552724305299386 0.1250937270928721 0.3264842134036382 2.0497796053186942e-07 6.68829283228059 -0.5812410465506096 HIIENAK(ub)QDVDDEYGVSQALAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HIIENAKQDVDDEYGVSQALAR 22 1 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8Y4C5;A0A2R8YG32;A0A2R8Y7F3;A0A2R8Y6N0;A0A2R8YF80;A0A2R8YF58;A0A2R8Y526;A0A2R8Y7Y7;A0A2R8Y6V2;A0A2R8YDA1;A0A2R8YGP5 P51532 SMARCA4 Transcription activator BRG1 1 6467300.0 2160400.0 1840700.0 2466200.0 True False 2091819.2845431704 2575701.1091236905 1820228.2355858881 1.0 1.2313210458264776 0.8701651471692046 20.99632678966862 -6.733717784016232 1.7097713085749875 1.138627651987085 0.8702331891986219 0.5763979982233371 0.09721643863089811 0.3292988490693479 1.8875504040866775 0.045029503112826004 0.11126631813247326 1.8462147483901882e-07 6.733717784016232 -0.26839446278846313 HIILVLSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HIILVLSGK 9 0 H3BNF0;H3BNS4;Q9Y5Y2;H3BRK5;H3BMW1 H3BNF0 NUBP2 Cytosolic Fe-S cluster assembly factor NUBP2 0 48402000.0 12687000.0 15676000.0 20039000.0 False True 16632779.861082787 13337201.904569421 17965556.507661212 1.0 0.801862467727098 1.0801295188002122 23.98752597274292 -6.7155241938233985 1.7756113610758664 0.8788798543041342 1.0795845187279276 0.4911980736104432 0.08342628630087229 0.36410331848066246 2.2409642852754184 0.03734406493573811 0.09423792059025508 1.9251997924112567e-07 6.7155241938233985 0.20070466442379342 HIILVLSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HIILVLSGK 9 0 H3BNF0;H3BNS4;Q9Y5Y2;H3BRK5;H3BMW1 H3BNF0 NUBP2 Cytosolic Fe-S cluster assembly factor NUBP2 0 47175000.0 21011000.0 10714000.0 15450000.0 False True 20344017.30583992 14992156.072771901 11403181.509935124 1.0 0.7369319366666228 0.5605176862812512 24.278101258595548 -8.19864704779836 0.103901957785607 1.511469847281036 2.189545604728491e-13 0.9999840174402693 0.0007218899382834907 0.08517497023725579 0.020322516033501454 0.13731717085574488 0.14278196576536886 6.329260229609321e-09 8.19864704779836 -1.511469847280817 HIILVLSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HIILVLSGK 9 0 H3BNF0;H3BNS4;Q9Y5Y2;H3BRK5;H3BMW1 H3BNF0 NUBP2 Cytosolic Fe-S cluster assembly factor NUBP2 0 139883000.0 37846000.0 53337000.0 48700000.0 False True 57415148.913213275 43818595.626116976 39074423.65403173 1.0 0.7631887481882461 0.6805594759162823 25.77492810457021 -13.999999999999998 0.14680916664197538 2.1398300189624586 0.5862292525779336 0.9995772354425596 0.002783572168530567 11.947166070347981 0.12049718668734416 3.8888022826766253 0.08477479806626859 1.0000000000000041e-14 13.999999999999998 -1.553600766384525 HIILVLSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HIILVLSGK 9 0 H3BNF0;H3BNS4;Q9Y5Y2;H3BRK5;H3BMW1 H3BNF0 NUBP2 Cytosolic Fe-S cluster assembly factor NUBP2 0 78568000.0 12687000.0 24659000.0 41222000.0 False True 17377726.75328346 23569483.843591616 31486212.593739048 1.0 1.3563042035482717 1.8118717736075485 24.05073603426581 -6.967775161335949 0.30670978912035246 0.9270325148915156 2.255555997120502 0.9999594581928127 0.0021156366775105843 0.07703144433244134 0.01160079095692235 0.007317746163760065 0.040576799429541704 1.077022654887748e-07 6.967775161335949 1.3285234822289862 HIILVLSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HIILVLSGK 9 0 H3BNF0;H3BNS4;Q9Y5Y2;H3BRK5;H3BMW1 H3BNF0 NUBP2 Cytosolic Fe-S cluster assembly factor NUBP2 0 37164400.0 21011000.0 7371700.0 8781700.0 False True 17471577.445122182 7331987.188932122 10617912.86800685 1.0 0.4196522730681716 0.6077249121527502 24.058506534029824 -10.178878461794547 5.488812719931721 1.0000151332467508 0.5136885926104026 0.8991416821614306 0.07678033338952427 1.4219215151573107e-05 2.1272785116478456e-06 0.07434454900427998 0.024780746044458457 6.624018522884414e-11 10.178878461794547 -0.4863265406363483 HIILVLSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HIILVLSGK 9 0 H3BNF0;H3BNS4;Q9Y5Y2;H3BRK5;H3BMW1 H3BNF0 NUBP2 Cytosolic Fe-S cluster assembly factor NUBP2 0 135376000.0 37846000.0 57884000.0 39646000.0 False True 48992393.05619076 54662704.51587456 32430834.802312486 1.0 1.1157386097302975 0.6619565360915652 25.54605442666266 -6.839067318746412 1.2867618715173783 1.0615788996845266 0.6473084758889919 0.9228329184928795 0.05348097623342848 0.16989011725629075 0.5468313531948868 0.03259579243267722 0.0750749146078173 1.4485473009644562e-07 6.839067318746412 -0.4142704237955347 HIK(ub)AEMGSER ddPTM_RPMI8226_Bortezomib_1h_R1 1 HIKAEMGSER 10 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-2;Q9UKT9-8;Q9UKT9-5;Q9UKT9-9;Q9UKT9-10;Q9UKT9-11 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 40297100.0 3361100.0 11947000.0 24989000.0 True False 4406434.648938704 10164554.169041252 22403377.99141409 1.0 2.3067525060173986 5.084241518664069 22.071180378239642 -6.9588372702256445 0.4515215972002124 0.9118117178426649 6.589570683080432 0.9997246161913173 0.028261407171122185 0.08011910585554391 0.02268589544033944 0.037209090560633 0.2296932964587183 1.0994177131488252e-07 6.9588372702256445 5.677758965237768 HIK(ub)AEMGSER ddPTM_RPMI8226_Bortezomib_2h_R1 1 HIKAEMGSER 10 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-2;Q9UKT9-8;Q9UKT9-5;Q9UKT9-9;Q9UKT9-10;Q9UKT9-11 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 6810150.0 569350.0 1974700.0 4266100.0 True False 551276.2958964332 2763208.0079244636 3148680.4297433174 1.0 5.012383134361323 5.7116194786195775 19.07241604334655 -9.629620352390196 0.48652853966688714 6.527606453434573e-22 5.712362724196727 0.9986179143153597 0.07717775963527819 0.9344623002945979 0.2118825800274738 1.7651641842985795 0.14482108283580575 2.3462789679576943e-10 9.629620352390196 5.712362724196727 HIK(ub)AEMGSER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HIKAEMGSER 10 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-2;Q9UKT9-8;Q9UKT9-5;Q9UKT9-9;Q9UKT9-10;Q9UKT9-11 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 4336250.0 569350.0 1819000.0 1947900.0 True False 473439.7514816199 1809200.6859567706 2355196.8839280005 1.0 3.8213958170916458 4.974649628717192 18.852821318780826 -9.090514001247909 0.3294078210679922 1.9848116080148644e-19 5.36763967190504 0.9983374773124808 0.06807638607734766 0.5283058373908431 0.11927297257404952 1.0256654662339668 0.3561242552379423 8.118690746141195e-10 9.090514001247909 5.36763967190504 HIK(ub)ENDYYTPTGEFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HIKENDYYTPTGEFR 15 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 23355800.0 3662500.0 3060300.0 16633000.0 True False 4801572.967700456 2603715.168955966 14911976.715002188 1.0 0.5422629597573154 3.1056440910745446 22.195075671189933 -6.860740022465882 1.18206438338012 0.7511688617337474 3.2314986798941923 0.9545298453541715 0.23802675799848233 0.14603663662165886 0.3873318850303216 0.15701377768042726 0.3668094400536557 1.3780341413778825e-07 6.860740022465882 2.480329818160445 up HIK(ub)ENDYYTPTGEFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HIKENDYYTPTGEFR 15 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 47169500.0 2945900.0 4122600.0 40101000.0 True False 2852384.0170041355 5768775.679074995 29597345.09578691 1.0 2.0224400517900643 10.37635357628776 21.443736794490246 -6.92970545941072 0.7492081733194391 0.871565188461178 12.078563088308151 0.9964800112464238 0.24917544328812755 0.09279102540092496 0.0784321081617757 0.22661444963153637 0.7571128993762206 1.1756946463307746e-07 6.92970545941072 11.206997899846973 HIK(ub)ENDYYTPTGEFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HIKENDYYTPTGEFR 15 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 137896700.0 6974700.0 44346000.0 86576000.0 True False 10581129.818870911 36432109.823120564 69464215.65239112 1.0 3.4431209565301555 6.564914790904956 23.33499034620571 -6.967784450340131 0.30652191809333745 0.4988746883232824 9.607897011356641 0.9999595797301015 0.01447959320534084 0.07702834889529349 0.011589956307203449 0.05018915010884339 0.27810622101967103 1.0769996189953469e-07 6.967784450340131 9.10902232303336 HIK(ub)ENDYYTPTGEFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HIKENDYYTPTGEFR 15 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 36256700.0 3662500.0 2812200.0 29782000.0 True False 5016625.225340952 2687947.705298203 22748104.97954341 1.0 0.5358079554598416 4.534543434624887 22.258285732712825 -6.877988771979373 1.0910010291914363 0.7193120934323342 4.807173373656574 0.9720245265430292 0.2986730139949487 0.12942435762633112 0.28320451922827933 0.211257919548727 0.5083462450470203 1.324375774465281e-07 6.877988771979373 4.08786128022424 up HIK(ub)ENDYYTPTGEFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HIKENDYYTPTGEFR 15 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 33186500.0 2945900.0 4839600.0 25401000.0 True False 2449646.3754978585 4813528.114214608 30712231.659045704 1.0 1.9649889724333465 12.537414365697517 21.224142069924522 -6.92475062115004 0.7887001453114031 0.8041803163541474 14.443601716840254 0.9954018409031732 0.35438778327003223 0.09545677812497509 0.09171828854947248 0.31329287246827286 0.9856723381999045 1.1891848804350883e-07 6.92475062115004 13.639421400486107 up HIK(ub)ENDYYTPTGEFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HIKENDYYTPTGEFR 15 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 124324700.0 6974700.0 30668000.0 86682000.0 True False 9028886.641891181 28961298.840661347 70906765.43242835 1.0 3.207626808192504 7.853323255100286 23.10611666829816 -6.95903763205274 0.4487909496394906 0.8483208019986492 10.396427761440203 0.9997328246997313 0.04668704240244379 0.08004670359186676 0.02241516395780085 0.06198385858374656 0.38434583515663706 1.0989106135992742e-07 6.95903763205274 9.548106959441553 HILANFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HILANFK 7 0 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;E9PJF7;H0YCX0;Q56UQ5 P13693 TPT1 Translationally-controlled tumor protein;TPT1-like protein 0 44306000.0 11304000.0 19594000.0 13408000.0 False True 14819653.468091706 16670651.576813813 12020668.778617783 1.0 1.1249015783471257 0.8111302200486378 23.821008377326898 -6.7986770280786635 1.4611894883073313 1.0690299093513438 0.8069330737959024 0.8283007920061974 0.053445305234303526 0.22265062067461955 0.9386221296691263 0.028775814858429154 0.0669801321095669 1.5897285430632272e-07 6.7986770280786635 -0.2620968355554414 HILANFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HILANFK 7 0 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;E9PJF7;H0YCX0;Q56UQ5 P13693 TPT1 Translationally-controlled tumor protein;TPT1-like protein 0 27808100.0 8491100.0 6947000.0 12370000.0 False True 8221554.678293147 9720973.3281264 9129925.907954538 1.0 1.182376534427494 1.1104865521431981 22.970979799555224 -10.377717390649616 5.1581046643945205 0.9999096692097368 1.1464315432853553 0.846904270340552 0.02934896236907369 3.0506181252481362e-05 3.680264999329805e-06 0.02843450764986601 0.009472336873652879 4.1906617621329414e-11 10.377717390649616 0.14652187407561856 HILANFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HILANFK 7 0 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;E9PJF7;H0YCX0;Q56UQ5 P13693 TPT1 Translationally-controlled tumor protein;TPT1-like protein 0 81716000.0 22960000.0 41830000.0 16926000.0 False True 34831998.60083965 34365109.68071824 13580568.68107067 1.0 0.9865959767203782 0.3898877246952835 25.053909918898935 -6.911742962804741 0.8837757827214567 1.017472711610581 0.30982607928110895 0.9915629077251695 0.02613263327891135 0.10327709520323997 0.13259704260741342 0.021581194793489328 0.06031890663135257 1.225341202905454e-07 6.911742962804741 -0.7076466323294721 down HILANFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HILANFK 7 0 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;E9PJF7;H0YCX0;Q56UQ5 P13693 TPT1 Translationally-controlled tumor protein;TPT1-like protein 0 36405000.0 11304000.0 10620000.0 14481000.0 False True 15483394.279113729 10150773.28435633 11060886.045556633 1.0 0.6555909577300618 0.7143708831646286 23.88421843884979 -10.595958084715635 6.451952033354098 1.0007788930009507 0.6849809204473503 0.9745521716160384 0.02399680407225523 0.00026948737075501903 1.687615153350286e-05 0.0232891313939866 0.007744935211170577 2.5353733164652312e-11 10.595958084715635 -0.3157979725536004 HILANFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HILANFK 7 0 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;E9PJF7;H0YCX0;Q56UQ5 P13693 TPT1 Translationally-controlled tumor protein;TPT1-like protein 0 25159100.0 8491100.0 10956000.0 5712000.0 False True 7060725.869510112 10896977.85340428 6906352.790696004 1.0 1.5433226065977173 0.9781363727091109 22.7513850749895 -6.655153838722298 1.9904040483707506 1.3511173136404178 0.9805196703785305 0.21515538194628459 0.23160504931649412 0.4959893901770084 3.772143545931996 0.09418696849847803 0.25658040275699545 2.2123109110915088e-07 6.655153838722298 -0.37059764326188727 HILANFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HILANFK 7 0 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;E9PJF7;H0YCX0;Q56UQ5 P13693 TPT1 Translationally-controlled tumor protein;TPT1-like protein 0 60702000.0 22960000.0 17908000.0 19834000.0 False True 29722172.609262288 16911404.05760283 16224415.514025794 1.0 0.5689827685185015 0.545869096694829 24.825036240991384 -13.999999999999998 0.4169548282504337 9.106265779840225 0.5450311154027662 0.9998603667044824 0.0024678386463590067 29.444645056823134 0.214963584267999 217.2494091008597 0.005652811586921148 1.0000000000000041e-14 13.999999999999998 -8.561234664437459 HILILQNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HILILQNK 8 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 31473200.0 9536000.0 8853200.0 13084000.0 False True 12501788.34675535 7532337.069503309 11730193.190590324 1.0 0.6025007671369044 0.938281217473556 23.57563114745512 -10.066710920725948 7.146615595221304 1.0000000491055558 0.7703909923052301 0.38403009443971425 0.13708179482112426 1.0727308199276043e-07 1.4114173957872395e-08 0.13272890479192728 0.04424295903420299 8.576085049146504e-11 10.066710920725948 -0.22960905680032573 HILILQNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HILILQNK 8 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 20637300.0 9044600.0 2627400.0 8965300.0 False True 8757484.123763736 3676534.521709992 6617018.976765136 1.0 0.41981629309878943 0.7555844673254533 23.062085036926096 -10.279907190874026 5.820162656081101 1.000026555571833 0.5877003802121434 0.6678197985570447 0.13707678312021707 4.723731451910002e-05 5.844442919232382e-06 0.13273255760910496 0.04424134151468921 5.24919624065911e-11 10.279907190874026 -0.41232617535968963 HILILQNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HILILQNK 8 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 27409900.0 8203100.0 12073000.0 7133800.0 False True 12444702.426940221 9918478.823220447 5723801.303144391 1.0 0.7970040972413274 0.45993878413304107 23.56902839775987 -6.963513420315662 0.3827087708235525 1.0224594262270974 0.222512531883105 0.9998791457749028 0.002448570499938266 0.07846910405410448 0.016661418549906524 0.004375128124687919 0.028445334654195614 1.0876435273835698e-07 6.963513420315662 -0.7999468943439925 down HILILQNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HILILQNK 8 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 34002500.0 9536000.0 6851500.0 17615000.0 False True 13061716.900710234 6548778.075119348 13454699.792312704 1.0 0.5013719195493554 1.0300866183664645 23.63884120897801 -10.11730333702936 13.552912205041975 1.0000178716615846 0.7657292689579128 0.2074671347414524 0.21584687218182358 0.0 0.0 0.208992835211355 0.06966427840378499 7.633024616277305e-11 10.11730333702936 -0.2342886027036718 HILILQNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HILILQNK 8 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 17002300.0 9044600.0 5466500.0 2491200.0 False True 7520985.643717683 5437050.879484712 3012098.401992624 1.0 0.7229173325209454 0.4004925078548242 22.842490312360372 -6.969133514298493 0.27811105791041146 1.0726666904110578 0.04094355815280679 0.9999748095405561 0.001229549160752164 0.0765849330492217 0.010032808411087326 0.006021131538055354 0.029665757404770465 1.073659288635545e-07 6.969133514298493 -1.031723132258251 down HILILQNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HILILQNK 8 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 27667400.0 8203100.0 9795900.0 9668400.0 False True 10619074.657275228 9250749.553711845 7908850.406161485 1.0 0.8711446008503264 0.7447777383072693 23.34015471985232 -6.971364806569841 0.2231939900667087 1.0559747905540453 0.5563659465417423 0.9999911569448153 0.00030979583260599806 0.07586227059735141 0.0074253713849067576 0.0034162184904916906 0.012722748553578654 1.0681572521363067e-07 6.971364806569841 -0.499608844012303 HILILQNK(ub)IDLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HILILQNKIDLVK 13 1 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 16329800.0 1793900.0 4814800.0 9721100.0 True False 2721477.4516570643 3955561.3217958957 7799720.324090518 1.0 1.4534609939124858 2.865987487547028 21.37595865222999 -6.950602427762581 0.5521944062547578 0.9807144745515893 3.4053422077466555 0.9992476879900578 0.02179503962063024 0.08324481956495917 0.03496877046413547 0.02358967382059594 0.11723027780660851 1.1204631352657947e-07 6.950602427762581 2.424627733195066 up HILILQNK(ub)IDLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HILILQNKIDLVK 13 1 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 18259200.0 1793900.0 3593300.0 12872000.0 True False 2322238.9130555564 3393329.6962354407 10529428.077873344 1.0 1.4612319504071027 4.5341708894279655 21.14708497432244 -6.9336609212832565 0.716101794383292 0.9590175720536297 5.228179357054275 0.9972101563994386 0.08285464016747232 0.09078090643726047 0.06869043806491298 0.07720145081671356 0.2726674477219547 1.1650352845613396e-07 6.9336609212832565 4.269161785000645 up HILLAVANDEELNQLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HILLAVANDEELNQLLK 17 0 O75367-2;O75367-3;O75367;D6RCF2;Q9P0M6 O75367-2;Q9P0M6 H2AFY;H2AFY2 Core histone macro-H2A.1;Histone H2A;Core histone macro-H2A.2 0 35102700.0 9703700.0 15028000.0 10371000.0 False True 14721222.3354951 12346135.985700076 8321167.304229214 1.0 0.8386624224764048 0.5652497540347324 23.811394130724885 -6.963150473643384 0.3884901835550125 1.0170770768652642 0.377034834023887 0.9998697953702076 0.0020475451484248475 0.0785943103566275 0.0171087201141137 0.0035332488917094737 0.023013868898965322 1.088552867965661e-07 6.963150473643384 -0.6400422428413772 HIMGQNVADYMR ddPTM_RPMI8226_Bortezomib_1h_R1 3 HIMGQNVADYMR 12 0 P46777;A0A2R8Y6J3 P46777 RPL5 60S ribosomal protein L5 0 55668480.0 12905080.0 26276000.0 16487400.0 False True 16918684.85297249 22355723.223045763 14781442.006308394 1.0 1.3213629438294092 0.8736755920902092 24.012114091426096 -6.714049843822835 1.7806383529861107 1.1967482754551275 0.87459316630714 0.48428934278478786 0.13533907476076626 0.36703630295045364 2.270910169079278 0.0604270841850572 0.1527715192325215 1.931746598425573e-07 6.714049843822835 -0.3221551091479875 HIMGQNVADYMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HIMGQNVADYMR 12 0 P46777;A0A2R8Y6J3 P46777 RPL5 60S ribosomal protein L5 0 10070200.0 3370200.0 1502000.0 5198000.0 False True 3263214.8457542136 2101756.4328265227 3836487.863342576 1.0 0.6440754078944968 1.1756773748238647 21.637862545016397 -6.72628590709785 1.736846044500263 0.7849248233218222 1.1751486934239932 0.5419421380092421 0.1496707904127732 0.3432399514921071 2.026740906682789 0.06833971009140084 0.17029331381834345 1.8780800219191569e-07 6.72628590709785 0.39022387010217097 HIMGQNVADYMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HIMGQNVADYMR 12 0 P46777;A0A2R8Y6J3 P46777 RPL5 60S ribosomal protein L5 0 64971200.0 13376200.0 37565000.0 14030000.0 False True 20292673.331208657 30861232.25331537 11256964.350432541 1.0 1.5208066354595595 0.5547304766947658 24.27445560065264 -6.76028650344622 1.6114650440131946 1.30240401516398 0.5511588557421062 0.6921256038824437 0.21906076178860284 0.28242742222753653 1.4455642072302837 0.10725531157209252 0.25767098067593486 1.7366547821017392e-07 6.76028650344622 -0.7512451594218738 HIMGQNVADYMR ddPTM_RPMI8226_Carfilzomib_1h_R1 3 HIMGQNVADYMR 12 0 P46777;A0A2R8Y6J3 P46777 RPL5 60S ribosomal protein L5 0 55669280.0 12905080.0 28616800.0 14147400.0 False True 17676436.822673842 27352415.152897224 10806075.49484896 1.0 1.5473941624825571 0.6113265701257075 24.075324152948987 -6.748223127899107 1.6566739395502756 1.3225612946463694 0.6097431556300866 0.6412023005073889 0.22999985755238345 0.30314635807848783 1.6364572611266597 0.10970374364313706 0.2668033908944071 1.7855699651309234e-07 6.748223127899107 -0.7128181390162828 HIMGQNVADYMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HIMGQNVADYMR 12 0 P46777;A0A2R8Y6J3 P46777 RPL5 60S ribosomal protein L5 0 12924100.0 3370200.0 6840300.0 2713600.0 False True 2802470.6251749494 6803449.946206755 3281001.2137312093 1.0 2.4276614659545404 1.1707531148614223 21.418267820450673 -6.615501121287535 2.1337647823850596 1.9502973233289995 1.1754711424422573 0.06770949246296998 0.6146582553814145 0.5976221732614787 5.164106950916495 0.23724481017084958 0.6817081367033483 2.423811706604153e-07 6.615501121287535 -0.7748261808867423 HIMGQNVADYMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HIMGQNVADYMR 12 0 P46777;A0A2R8Y6J3 P46777 RPL5 60S ribosomal protein L5 0 25152200.0 13376200.0 0.0 11776000.0 False True 17315754.584321156 0.0 9632888.831963688 1.0 0.0 0.5563077707676656 24.04558192274509 -10.170645768758487 5.921336758597538 1.0000088625481496 0.2781538853838217 0.6918244515421563 0.2271116963877034 2.657201138679522e-05 3.7218658281259504e-06 0.21990264797409947 0.07329998481986817 6.750784292851263e-11 10.170645768758487 -0.7218549771643279 HIMIDLGTGNNNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HIMIDLGTGNNNK 13 0 P83876;K7ESL1 P83876 TXNL4A Thioredoxin-like protein 4A 0 32648700.0 9835000.0 9784000.0 13029700.0 False True 12893780.242275493 8324265.3377332855 11681511.633707939 1.0 0.6456031653494523 0.9059803575220844 23.620171964158853 -10.45552866701629 5.402480798223863 1.0002565403276853 0.7757917614357669 0.4971425172964914 0.10629854358026278 0.00032882902862514104 3.3139824495650135e-05 0.10303983450711228 0.03430770741770437 3.5032516318937437e-11 10.45552866701629 -0.2244647788919184 HIMIDLGTGNNNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HIMIDLGTGNNNK 13 0 P83876;K7ESL1 P83876 TXNL4A Thioredoxin-like protein 4A 0 21540800.0 7766800.0 2267400.0 11506600.0 False True 7520247.185331376 3172784.644334795 8492676.269399313 1.0 0.42189898365621176 1.1293081277919572 22.842348652396087 -6.6894542228520235 1.8682860718021412 0.6373852794093174 1.1268525852766458 0.36791864577948474 0.24452263599727408 0.4178340218439065 2.8272287621353613 0.10471794381352455 0.2728874823478814 2.0443054062491765e-07 6.6894542228520235 0.48946730586732834 HIMIDLGTGNNNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HIMIDLGTGNNNK 13 0 P83876;K7ESL1 P83876 TXNL4A Thioredoxin-like protein 4A 0 27666600.0 6455500.0 10977000.0 10234100.0 False True 9793465.460266551 9018068.586307544 8211325.649234625 1.0 0.9208250769755711 0.8384494418803142 23.223388023399426 -6.970627633629966 0.24274954388945502 1.02858832577284 0.7282955215523882 0.9999868592935194 0.00023902534479211266 0.07609973140364604 0.008299094560673893 0.001931352849405331 0.00799200732741134 1.0699718855584532e-07 6.970627633629966 -0.3002928042204519 HIMIDLGTGNNNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HIMIDLGTGNNNK 13 0 P83876;K7ESL1 P83876 TXNL4A Thioredoxin-like protein 4A 0 35853800.0 9835000.0 6808400.0 19210400.0 False True 13471265.280881438 6507582.375631991 14673299.170607071 1.0 0.48307135521023553 1.0892294721143656 23.683382025681745 -6.680883809645338 1.8990211257873078 0.6731812097227702 1.0869207748602905 0.32799703570163674 0.21904649948239327 0.43659524986044795 3.044948519517536 0.092535462050249 0.2437556050104896 2.085048638598568e-07 6.680883809645338 0.4137395651375203 HIMIDLGTGNNNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HIMIDLGTGNNNK 13 0 P83876;K7ESL1 P83876 TXNL4A Thioredoxin-like protein 4A 0 15117300.0 7766800.0 3602700.0 3747800.0 False True 6458438.327579603 3583291.540020038 4531447.652130682 1.0 0.5548232185973246 0.7016321008718079 22.622753927830363 -10.383898007307792 5.087106513579198 1.000272961009229 0.6282276597345338 0.8952927294260175 0.05993447521358169 0.0001856796436746862 2.248765479958768e-05 0.05807331322163601 0.019343768697140648 4.1314451628731325e-11 10.383898007307792 -0.37204530127469515 HIMIDLGTGNNNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HIMIDLGTGNNNK 13 0 P83876;K7ESL1 P83876 TXNL4A Thioredoxin-like protein 4A 0 26930300.0 6455500.0 15991500.0 4483300.0 False True 8356772.00692911 15101558.967341747 3667385.402542696 1.0 1.807104340625797 0.43885191548864116 22.994514345491876 -6.746809604611937 1.6612436942872084 1.4763714634283607 0.4367064258693831 0.6353715913495589 0.3391113071913891 0.3056052540277371 1.6582680269188754 0.16131233768117967 0.3930062477108758 1.7913910305737722e-07 6.746809604611937 -1.0396650375589775 HIPIAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HIPIAGR 7 0 P61158;B4DXW1;C9IZN3;Q9P1U1-2;Q9P1U1;A0A0A0MTI9;H7C4J1;Q9C0K3;Q9P1U1-3 P61158;Q9P1U1-2 ACTR3;ACTR3C;ACTR3B Actin-related protein 3;Actin-related protein 3B;Actin-related protein 3C 0 3898790.0 920290.0 1821600.0 1156900.0 False True 1206509.1021010368 1549824.380541187 1037195.0857684161 1.0 1.2845525805336195 0.8596661922916501 20.202407368845094 -6.72621959894166 1.7367876259044903 1.1719592350874317 0.8600788768203725 0.5417191721544903 0.11965923383691142 0.34338964477845807 2.0273969098179094 0.054635266671819865 0.13616955279924864 1.8783667893912042e-07 6.72621959894166 -0.3118803582670592 HIPIAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HIPIAGR 7 0 P61158;B4DXW1;C9IZN3;Q9P1U1-2;Q9P1U1;A0A0A0MTI9;H7C4J1;Q9C0K3;Q9P1U1-3 P61158;Q9P1U1-2 ACTR3;ACTR3C;ACTR3B Actin-related protein 3;Actin-related protein 3B;Actin-related protein 3C 0 2029220.0 579100.0 594910.0 855210.0 False True 560716.7874833143 832460.6654146665 631204.8452499426 1.0 1.4846366008605347 1.1257106249359903 19.096912738206385 -10.63052606383243 10.973435299599242 0.9999730781391186 1.3051736128982452 0.49080388749444115 0.14653091607426894 9.652944934845142e-05 3.250174597527033e-06 0.14189040269614184 0.047292649805013395 2.3413909542663964e-11 10.63052606383243 0.30520053475912656 HIPIAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HIPIAGR 7 0 P61158;B4DXW1;C9IZN3;Q9P1U1-2;Q9P1U1;A0A0A0MTI9;H7C4J1;Q9C0K3;Q9P1U1-3 P61158;Q9P1U1-2 ACTR3;ACTR3C;ACTR3B Actin-related protein 3;Actin-related protein 3B;Actin-related protein 3C 0 6662000.0 1526200.0 3614100.0 1521700.0 False True 2315356.980165567 2969135.617907814 1220935.3280151964 1.0 1.2823662369746098 0.5273205550912022 21.142803213699665 -6.805415730388093 1.4336708823951398 1.1547409335879506 0.5154463545522189 0.8475321690779669 0.12162904170842713 0.2131178867810257 0.8641502260669471 0.0667241529241563 0.15469491058576254 1.5652520080546093e-07 6.805415730388093 -0.6392945790357317 HIPIAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HIPIAGR 7 0 P61158;B4DXW1;C9IZN3;Q9P1U1-2;Q9P1U1;A0A0A0MTI9;H7C4J1;Q9C0K3;Q9P1U1-3 P61158;Q9P1U1-2 ACTR3;ACTR3C;ACTR3B Actin-related protein 3;Actin-related protein 3B;Actin-related protein 3C 0 3943190.0 920290.0 1565400.0 1457500.0 False True 1260546.0829021211 1496235.4519144439 1113268.5181547417 1.0 1.1869740203941623 0.8831636806103064 20.265617430367985 -6.740159519571889 1.6858198547826022 1.111223628265254 0.8829680412927737 0.6058322794339719 0.07855816104990912 0.3175030298419537 1.7717598705354136 0.036861724813014134 0.09044975550415796 1.8190325917773567e-07 6.740159519571889 -0.22825558697248016 HISESHEK(ub)GENVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HISESHEKGENVK 13 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;H0YBA1 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 5800460.0 2927900.0 2310600.0 561960.0 True False 3838505.253823931 1965867.4866482592 503813.7699009579 1.0 0.5121440135297082 0.13125259354511942 21.872113192063967 -8.04468949443467 0.3777139753502427 1.0747796643348315 1.605032654706813e-22 0.9978881772879831 0.01633958925678478 0.09593958288266356 0.08314527282370272 0.052308355641395604 0.08412193394234913 9.0221596033807e-09 8.04468949443467 -1.0747796643348315 down HISESHEK(ub)GENVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HISESHEKGENVK 13 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;H0YBA1 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 4949990.0 2485000.0 2029200.0 435790.0 True False 2066387.6041658465 2018268.296835335 526911.674134701 1.0 0.9767133197888418 0.25499169326821586 20.978679463487914 -6.913769861527494 0.8696756050032252 1.0197711943414338 0.1537926510687834 0.9922678646470331 0.030410794276902887 0.10197786884366242 0.12563843369294278 0.025371350514281552 0.07200750636424824 1.2196357290488342e-07 6.913769861527494 -0.8659785432726504 down HISQISVAEDDDESLLGHLMIVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HISQISVAEDDDESLLGHLMIVGK 24 0 P49773 P49773 HINT1 Histidine triad nucleotide-binding protein 1 0 53332400.0 12595900.0 40736500.0 0.0 False True 19108901.183637474 33466753.299272813 0.0 1.0 1.751369844746994 0.0 24.187741485829125 -6.801177395884443 1.5242459594594502 1.419215047711261 9.28390503760575e-21 0.8012898210063396 0.3197909619021734 0.2282306266558915 1.058230466699063 0.16689695102918356 0.3757937104251555 1.5806022801720454e-07 6.801177395884443 -1.419215047711261 HISVLVPCFLTFPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HISVLVPCFLTFPK 14 0 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 0 16527670.0 3106870.0 8611000.0 4809800.0 False True 4073136.6569718746 7326272.365415113 4312128.034859469 1.0 1.798680717690858 1.0586750207554465 21.95770878804268 -10.45626755320308 4.429710029323056 0.9983267790989562 1.428677869223679 0.30912307479466195 0.30210606070971435 0.005010190271649781 0.0006149834785366567 0.2935681285741273 0.09750431182609703 3.497296447975918e-11 10.45626755320308 0.43035109012472283 HISVLVPCFLTFPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HISVLVPCFLTFPK 14 0 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 0 2901050.0 1935400.0 965650.0 0.0 False True 1873961.7863843977 1351239.0807982257 0.0 1.0 0.7210601041151924 0.0 20.837660103348046 -7.3875642044387755 0.7675939789821971 0.9901184525305304 4.646999968221068e-18 0.987542197039253 0.04702749698271759 0.1121555165330303 0.13867661323702432 0.04063484331886224 0.07268528544586526 4.096715410593537e-08 7.3875642044387755 -0.9901184525305304 down HISVLVPCFLTFPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HISVLVPCFLTFPK 14 0 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 0 67144700.0 23297300.0 22802700.0 21044700.0 False True 35343707.360772714 18733380.02669171 16885205.820780326 1.0 0.5300343802496372 0.4777429161130075 25.074950042824124 -13.999999999999998 0.31001793479826284 5.543317911484259 0.46616477811433055 0.9996720354665233 0.004252925608906429 17.270934727034568 0.17716026540743368 50.61779341842042 0.01811942242388301 1.0000000000000041e-14 13.999999999999998 -5.0771531333699285 HISVLVPCFLTFPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HISVLVPCFLTFPK 14 0 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 0 47086170.0 3106870.0 12236300.0 31743000.0 False True 4255563.799004783 11695659.805966986 24245957.16760613 1.0 2.748322045765631 5.69747237094092 22.02091884956557 -6.963233074595999 0.387181195088035 0.813087388736914 7.738196220278795 0.9998719628003173 0.02193491492835619 0.07856576697984466 0.017006584011688683 0.038144206426993926 0.24837964596547465 1.0883458495544614e-07 6.963233074595999 6.9251088315418805 HISVLVPCFLTFPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HISVLVPCFLTFPK 14 0 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 0 10049420.0 1935400.0 209820.0 7904200.0 False True 1609370.8527575783 208689.6580139907 9556931.675108429 1.0 0.1296715779687517 5.938302945360974 20.618065378782322 -6.868756618161737 1.1407167650386603 0.5113313921304887 6.270449760444878 0.963423075862085 0.4891959508647806 0.13804922881980242 0.3365208857862404 0.333078417828961 0.786882865412431 1.352830487007362e-07 6.868756618161737 5.75911836831439 up HISVLVPCFLTFPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HISVLVPCFLTFPK 14 0 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 0 47714500.0 23297300.0 11414500.0 13002700.0 False True 30158814.108439293 10779273.040848082 10636342.018968606 1.0 0.3574170059237089 0.3526777273378351 24.846076364916573 HITIFSPEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HITIFSPEGR 10 0 G3V5Z7;P60900;G3V295;G3V3I1;G3V3U4;G3V4S5;G3V2S7 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 18192100.0 4835100.0 5801700.0 7555300.0 False True 6338862.923175001 4936108.97484947 6773550.03155511 1.0 0.7787057449693325 1.0685749342821225 22.59579263962235 -6.7026442320861825 1.8212555047828758 0.8629451842693633 1.0677624061358242 0.43023476158063045 0.09336632080118364 0.39003972314262997 2.5169866428755934 0.040868244573937874 0.1047678264645895 1.9831509298438734e-07 6.7026442320861825 0.2048172218664609 HITIFSPEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HITIFSPEGR 10 0 G3V5Z7;P60900;G3V295;G3V3I1;G3V3U4;G3V4S5;G3V2S7 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 7617900.0 4961600.0 2656300.0 0.0 False True 4804096.723842529 3716974.442421502 0.0 1.0 0.7737093268697767 0.0 22.19583376732925 -7.293260139292387 0.8229948384976505 0.9889842511271147 3.3504398534827587e-18 0.9883553644973243 0.04620210494657502 0.10317752717576398 0.13751589076712611 0.039359509258373254 0.06960405823995584 5.090258768575018e-08 7.293260139292387 -0.9889842511271147 down HITIFSPEGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HITIFSPEGR 10 0 G3V5Z7;P60900;G3V295;G3V3I1;G3V3U4;G3V4S5;G3V2S7 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 42320800.0 11726000.0 21844000.0 8750800.0 False True 17789199.28542883 17945767.532049026 7021200.544388109 1.0 1.0088013093848716 0.39468895883015875 24.08449823873236 -6.903651644997531 0.9379155230699511 1.0230378894151506 0.32523102318931957 0.9882965177106541 0.031096373660902007 0.1087664151761639 0.16265738453234393 0.02468551126767332 0.0654863195840765 1.248384463195274e-07 6.903651644997531 -0.697806866225831 down HITIFSPEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HITIFSPEGR 10 0 G3V5Z7;P60900;G3V295;G3V3I1;G3V3U4;G3V4S5;G3V2S7 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 24896300.0 4835100.0 10390000.0 9671200.0 False True 6622767.133664437 9930935.444864638 7387061.744616211 1.0 1.4995145147689593 1.1154041196868845 22.65900270114524 -10.786187438071961 12.141102404386958 0.999220420511166 1.3074593172277122 0.4607080892649824 0.15681241214165623 0.0033159039031699783 5.8395028267581864e-05 0.15214571486952605 0.050610988391937325 1.6361102367554683e-11 10.786187438071961 0.30823889671654625 HITIFSPEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HITIFSPEGR 10 0 G3V5Z7;P60900;G3V295;G3V3I1;G3V3U4;G3V4S5;G3V2S7 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 9723500.0 4961600.0 2823900.0 1938000.0 False True 4125790.2361486014 2808687.0901997364 2343226.8397004274 1.0 0.6807634245655755 0.567946188628294 21.976239042763527 -13.999999999999998 0.14493509497273718 2.53288324461568 0.43629472496001637 0.9995840122384356 0.003731860755815125 11.942290646020524 0.11961372019569542 5.1647685392869604 0.11812825988336316 1.0000000000000041e-14 13.999999999999998 -2.096588519655664 HITLIFNPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HITLIFNPTR 10 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;H3BUC9;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 53818100.0 21125600.0 19265400.0 13427100.0 False True 27695866.180601418 16391077.415941028 12037792.493837912 1.0 0.5918239678462042 0.43464221033351735 24.72316732330916 -13.999999999999996 0.1321379632706908 2.9406446455469144 0.2203819851171143 0.9996360469368575 0.004545560054953095 11.934007228697217 0.11324816311717822 6.003989499280106 0.19071257689658552 1.0000000000000082e-14 13.999999999999996 -2.7202626604298 HITLIFNPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HITLIFNPTR 10 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;H3BUC9;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 58623400.0 21640000.0 17661000.0 19322400.0 False True 20953050.04513712 24713129.400898293 14261283.780425252 1.0 1.1794526022541445 0.6806304451954992 24.32065693031817 -6.80939912480023 1.4170055469624228 1.097870619911177 0.6720191321470556 0.8582608509654915 0.07766699005658943 0.20762440231675236 0.8217599351216417 0.04309871388308402 0.0997260100533857 1.5509609924562012e-07 6.80939912480023 -0.4258514877641214 HITLIFNPTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HITLIFNPTR 10 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;H3BUC9;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 148231000.0 47436000.0 52929000.0 47866000.0 False True 71963880.03612489 43483406.41383552 38405264.11958696 1.0 0.6042393266178455 0.533674172380756 26.100769637876652 -13.999999999999998 0.2425307352353049 3.6520493887634897 0.5032145126552116 0.999529231999001 0.004452860699391366 13.714186349514488 0.1558581078483985 17.64105441198022 0.03397564364600207 1.0000000000000041e-14 13.999999999999998 -3.1488348761082783 HITLIFNPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HITLIFNPTR 10 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;H3BUC9;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 81522900.0 21125600.0 29951300.0 30446000.0 False True 28936305.21787379 28627952.53029584 23255281.85505266 1.0 0.9893437436031923 0.8036714321318399 24.78637738483205 -6.918701827064029 0.8343079332202962 1.0042915528097702 0.7746071604055387 0.9938124559359508 0.007090771134850587 0.09894152368718229 0.1096198027867264 0.006067795424550483 0.0179561166712573 1.2058635642368663e-07 6.918701827064029 -0.22968439240423155 HITLIFNPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HITLIFNPTR 10 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;H3BUC9;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 40500100.0 21640000.0 7849300.0 11010800.0 False True 17994618.81454687 7807014.2629359355 13313107.371812934 1.0 0.43385271693695104 0.739838254370279 24.101062205752445 -10.102609866111138 5.3576075604595825 1.000006430553214 0.5868454856533669 0.7085288389726707 0.1249180725647389 9.59515390648137e-06 1.6072163435446432e-06 0.12095328542620948 0.04031713455683117 7.895690820496136e-11 10.102609866111138 -0.413160944899847 HITLIFNPTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HITLIFNPTR 10 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;H3BUC9;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 154519000.0 47436000.0 63865000.0 43218000.0 False True 61406837.103352085 60310856.608153075 35352767.45412758 1.0 0.9821521422223002 0.5757138638263741 25.871895959969102 -6.916101908770146 0.8531297743982046 1.0102883549983357 0.5157070306218351 0.9930279565731568 0.016360675428595393 0.10052017845492701 0.11789815280462587 0.013812780049580153 0.039952539175313904 1.213104157788225e-07 6.916101908770146 -0.4945813243765006 HITTLQASFLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HITTLQASFLTK 12 0 Q9UL25 Q9UL25 RAB21 Ras-related protein Rab-21 0 14007100.0 4871800.0 5533400.0 3601900.0 False True 6386976.978578305 4707838.28902427 3229209.9398645167 1.0 0.737099617677376 0.5055928572617645 22.606701819749304 -6.972621320341191 0.1851576602016756 1.1671859386711374 0.06921354929014957 0.9999962661706965 0.0003902388122767374 0.07546091498102205 0.005873652003605928 0.008520984501508448 0.025585432733281926 1.0650712940046902e-07 6.972621320341191 -1.0979723893809878 HITTLQASFLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HITTLQASFLTK 12 0 Q9UL25 Q9UL25 RAB21 Ras-related protein Rab-21 0 5036200.0 1673400.0 1152400.0 2210400.0 False True 1620278.8329728497 1612559.3296866077 1631429.9294213988 1.0 0.9952356945427235 1.0068822083098434 20.627810676466098 HITTLQASFLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HITTLQASFLTK 12 0 Q9UL25 Q9UL25 RAB21 Ras-related protein Rab-21 0 9955100.0 4871800.0 2229700.0 2853600.0 False True 6673036.115444643 2131184.4813681114 2179638.4517367864 1.0 0.3193725381517892 0.3266336962708842 22.669911881272196 -10.326934231387462 8.798264343733896 1.0000008105431022 0.32300311721248687 0.9999137291866783 0.0029643553889083336 4.713113588102944e-08 3.6021206487446523e-09 0.0028702281841682057 0.0009567415877901812 4.710486555805748e-11 10.326934231387462 -0.6769976933306153 HIVEWNVQTCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HIVEWNVQTCK 11 0 Q15061;C9JEE7 Q15061 WDR43 WD repeat-containing protein 43 0 6391100.0 1758500.0 1941400.0 2691200.0 False True 2305410.5293382257 1651750.68751793 2412740.439813259 1.0 0.7164670528298791 1.0465556607420556 21.136592246618267 -6.679369179989992 1.9042629651560348 0.8205039793073822 1.0452896462512766 0.32121466425107936 0.1201845015625606 0.43990528096015796 3.083638221020016 0.05065467951825626 0.13369980088355907 2.0923330735538795e-07 6.679369179989992 0.22478566694389446 HIVEWNVQTCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HIVEWNVQTCK 11 0 Q15061;C9JEE7 Q15061 WDR43 WD repeat-containing protein 43 0 4334000.0 1758500.0 1203700.0 1371800.0 False True 2408664.971675649 1150516.5538963957 1047809.0931078385 1.0 0.477657360996955 0.4350165363092832 21.19980230814116 -13.999999999999991 0.35505231594064485 7.627500359186512 0.4295133844529055 0.9997642157004216 0.003944392223294577 21.173305490042416 0.19218686199768878 106.08760155789744 0.01250733873609991 1.0000000000000205e-14 13.999999999999991 -7.197986974733607 HIVLSGGSTMYPGLPSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HIVLSGGSTMYPGLPSR 17 0 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 0 19928000.0 6194200.0 7927500.0 5806300.0 False True 8120656.184718124 6744747.901152966 5205519.77396244 1.0 0.8305668590976165 0.6410220622021235 22.9531648775462 -6.969673450890751 0.2658693613101509 1.0495425006907892 0.4163793562035783 0.9999797212717882 0.0006602721232833731 0.0764087887270521 0.009408598724036049 0.0038117748562626255 0.017731003913475554 1.0723252911981971e-07 6.969673450890751 -0.633163144487211 HIVLSGGSTMYPGLPSR ddPTM_RPMI8226_Bortezomib_2h_R1 2 HIVLSGGSTMYPGLPSR 17 0 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 0 54410200.0 17440400.0 11596800.0 25373000.0 False True 16886764.048392322 16227462.716513062 18727050.126316108 1.0 0.9609575090887809 1.10897801808861 24.009389560224623 -6.836588859989469 1.2981732580133456 0.9792127455863628 1.1135259449279888 0.9184232747031695 0.017890166393938128 0.1728211223987544 0.5672236175348453 0.0108119265456448 0.024890026771365228 1.4568375940629708e-07 6.836588859989469 0.134313199341626 HIVLSGGSTMYPGLPSR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 HIVLSGGSTMYPGLPSR 17 0 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 0 68781200.0 22339200.0 19125700.0 27316300.0 False True 30598605.934180636 18280663.333767787 20864752.536857877 1.0 0.597434516235496 0.6818857232169061 24.866962589754994 -10.1689388993546 7.550346279756891 1.0000001913873229 0.6396601197262011 0.9604345497656541 0.03447706087777051 1.110418426716113e-07 1.2254130899844054e-08 0.033382288061289365 0.011127423550482041 6.777368513184649e-11 10.1689388993546 -0.3603400716611218 HIVLSGGSTMYPGLPSR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 HIVLSGGSTMYPGLPSR 17 0 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 0 42507400.0 17440400.0 14595200.0 10471800.0 False True 14502465.340721976 14516572.760679621 12661404.963867364 1.0 1.0009727601222416 0.8730519029971384 23.7897948356589 -6.905187254420405 0.9279045575569816 1.0045883548794468 0.8581161177228015 0.9889746668177819 0.006307915328521996 0.10768673210137265 0.1566740933002979 0.0050445059595575666 0.013501534652865238 1.2439781310210732e-07 6.905187254420405 -0.14647223715664526 HIVLSGGSTMYPGLPSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HIVLSGGSTMYPGLPSR 17 0 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 0 78551000.0 19964000.0 34834000.0 23753000.0 False True 25843791.549273174 32895457.278453052 19430197.72636154 1.0 1.2728572437111378 0.7518323187724361 24.623314407929826 -6.764369480475508 1.5957391650507826 1.1576222427812028 0.7494861423056273 0.7086840583567594 0.11484906723818784 0.2756218490572132 1.3841057511302908 0.05675850819186499 0.1358332565096339 1.720404300633931e-07 6.764369480475508 -0.4081361004755756 HIWITAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HIWITAAK 8 0 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 0 15651300.0 4770000.0 5150800.0 5730500.0 False True 6253516.192745703 4382320.71766115 5137562.830837504 1.0 0.7007770640691383 0.8215478576352382 22.576236177885832 -10.055571376928349 5.744917903870775 1.0000008962659286 0.7611624610439329 0.8390883074308906 0.04930447001147572 5.65985988367822e-07 9.305515930878978e-08 0.04773902671371023 0.01591294927064697 8.798904885244497e-11 10.055571376928349 -0.23883843522199566 HIWITAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HIWITAAK 8 0 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 0 14746700.0 4093300.0 6039000.0 4614400.0 False True 6209835.360314326 4961293.267077638 3702361.817436629 1.0 0.7989411923517582 0.5962093360957036 22.566123588493483 -6.971022424629922 0.2324762065287592 1.079938139079061 0.3094024396994973 0.999989293973974 0.0005393505892584931 0.07597234024183931 0.007833109313513303 0.00511537115014908 0.0200397530827352 1.0689996804068315e-07 6.971022424629922 -0.7705356993795637 HIWITAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HIWITAAK 8 0 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 0 10949500.0 4093300.0 3610900.0 3245300.0 False True 5298857.541005806 3409950.240763797 2654688.6995899915 1.0 0.6435255551551468 0.5009926534250796 22.337249910585932 -13.999999999999694 0.12642398955944215 2.694142950343016 0.2920142370327362 0.9996620922647296 0.0038578296591842394 11.943735532173026 0.11020209331072625 5.045488144499973 0.18564031904818434 1.0000000000007035e-14 13.999999999999694 -2.40212871331028 HIYLLPSGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HIYLLPSGR 9 0 P17174;P17174-2 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 5645600.0 2282400.0 1627400.0 1735800.0 False True 1897916.727464036 1618632.8731863936 2098747.7545675966 1.0 0.8528471506487976 1.10581656412919 20.855985263732624 -6.748984391802852 1.6533965012380951 0.9133694945817331 1.1062874531172397 0.644703138693519 0.061831844589441694 0.30180523193590025 1.622936831888895 0.029544750549106075 0.0718091376869072 1.7824428258698976e-07 6.748984391802852 0.19291795853550664 HIYYITGETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HIYYITGETK 10 0 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 503728400.0 163448400.0 155160000.0 185120000.0 False True 214282435.23655698 132010732.80894311 165965558.19642913 1.0 0.616059513525735 0.7745177900989016 27.67493835603043 -10.13789078259029 5.2240979681316855 1.0000095531284645 0.695288653405693 0.8313785947133872 0.06469032052168916 7.197956644918624e-06 1.1878236783558947e-06 0.0626380964772924 0.020878711169988646 7.279628513493758e-11 10.13789078259029 -0.3047208997227715 HIYYITGETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HIYYITGETK 10 0 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 291043600.0 73819600.0 50764000.0 166460000.0 False True 71476237.20480609 71034329.93076271 122859132.3070422 1.0 0.9938174239254208 1.718880807267525 26.090960351348993 -6.9049781962389725 0.9292728103785749 0.9738316111360509 1.8031710278169562 0.9888839108003096 0.03588410376902522 0.10783310982409627 0.1574808401146398 0.028667934358482923 0.07663466444759784 1.2445770942147305e-07 6.9049781962389725 0.8293394166809053 HIYYITGETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HIYYITGETK 10 0 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 708007300.0 301010000.0 252417300.0 154580000.0 False True 456654176.7786907 207371460.6696336 124027195.24517903 1.0 0.4541105090343507 0.2715998266348642 28.766526788029314 -13.999999999999998 0.15305714229602185 3.652805068941932 0.0776920203062045 0.9995563581055226 0.006518029348214007 11.970513446337886 0.12336080858428959 9.436878793731866 0.17531781674494357 1.0000000000000041e-14 13.999999999999998 -3.5751130486357274 HIYYITGETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HIYYITGETK 10 0 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 376767400.0 163448400.0 94426000.0 118893000.0 False True 223879690.50692606 90253947.09497473 90812922.07819664 1.0 0.4031359293494404 0.40563269438407235 27.738148417553322 -9.970971827316967 7.070140254840393 1.0000000315931274 0.40438431186676954 0.9999868206933276 0.001019300057081262 5.073746968498449e-10 7.488284269532317e-11 0.000986933095290265 0.000328977678821579 1.0691242310620549e-10 9.970971827316967 -0.5956157197263579 HIYYITGETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HIYYITGETK 10 0 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 258631000.0 73819600.0 121969400.0 62842000.0 False True 61384268.16276912 121312326.63316967 75981971.6514212 1.0 1.9762771515250908 1.2378085448529614 25.87136562678327 -10.107498824876991 4.430068623555474 0.9999370233127789 1.6070428482200294 0.473954507494981 0.30147854636073557 45627021.5123157 52050578.448944315 24199.627415195657 0.10320412321966509 7.807305526519568e-11 10.107498824876991 0.6071058249072505 HIYYITGETK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HIYYITGETK 10 0 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 771253800.0 301010000.0 276523800.0 193720000.0 False True 389663378.7941653 261135007.44604415 158464947.7350547 1.0 0.6701553742467171 0.4066713896118059 28.537653110121763 -7.503103653392501 0.19397174532164999 1.2095010247767124 7.438800164857672e-15 0.9999562389295003 0.0016056999450856217 0.12920469975803422 0.018004903923553854 0.03314437538500909 0.06622454707989545 3.1397592357311614e-08 7.503103653392501 -1.2095010247767048 down HK(ub)AELTCNGVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HKAELTCNGVR 11 1 Q9NWK9-2;Q9NWK9 Q9NWK9-2 ZNHIT6 Box C/D snoRNA protein 1 1 3591510.0 338910.0 1069200.0 2183400.0 True False 514151.2476398327 878392.9063022702 1751850.0329817855 1.0 1.708432898557492 3.407265937841254 18.971833293237808 -6.956348419354442 0.48416766027145897 0.9607802551695623 4.226247632830005 0.9996098550579218 0.019951714890018152 0.08103237587578663 0.026154906397228835 0.02415920597318839 0.14012293838475823 1.1057363342460203e-07 6.956348419354442 3.2654673776604426 HK(ub)AELTCNGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HKAELTCNGVR 11 1 Q9NWK9-2;Q9NWK9 Q9NWK9-2 ZNHIT6 Box C/D snoRNA protein 1 1 2225560.0 1043600.0 706990.0 474970.0 True False 867799.6393189054 703181.3045434724 574284.0309868479 1.0 0.8103037529439006 0.6617703038429195 19.727002460968357 -6.973869434757053 0.13721144905630506 1.2070880780447033 0.2611202495702463 0.9999990131838302 0.00013738537774360014 0.07506594282120244 0.0041449300142503386 0.008645629614077544 0.019593641795729182 1.0620147907683379e-07 6.973869434757053 -0.945967828474457 HK(ub)ALDLDDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HKALDLDDR 9 1 D6REL5;Q6UWZ7-2;Q6UWZ7 D6REL5 FAM175A BRCA1-A complex subunit Abraxas 1 5345470.0 1713000.0 1619300.0 2013170.0 True False 2245759.5887155957 1377706.751981964 1804866.4800902433 1.0 0.6134702747812414 0.8036775125704751 21.098772063076957 -10.156475603532376 4.973222251126914 1.0000185991822954 0.708573893675211 0.7578680776295429 0.07765177966355129 108709180.79348618 1.396502483267531 23153.411744633566 0.026582269594752232 6.974681760160838e-11 10.156475603532376 -0.29144470550708446 HK(ub)ALDLDDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HKALDLDDR 9 1 D6REL5;Q6UWZ7-2;Q6UWZ7 D6REL5 FAM175A BRCA1-A complex subunit Abraxas 1 8856400.0 2012300.0 2408500.0 4435600.0 True False 1948420.6379773307 3370226.610161575 3273783.2948523154 1.0 1.7297222912092696 1.68022409075427 20.893873738948503 -10.451212634992862 4.637621646274794 0.9979904239850843 1.7049731909821317 0.9963162332631692 0.020207555718028618 0.0004208709200289663 4.9803169016666315e-05 0.019612506122839785 0.006521960563448838 3.538240628097872e-11 10.451212634992862 0.7069827669970474 HK(ub)ALDLDDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HKALDLDDR 9 1 D6REL5;Q6UWZ7-2;Q6UWZ7 D6REL5 FAM175A BRCA1-A complex subunit Abraxas 1 7812900.0 2012300.0 5576660.0 223940.0 True False 1673316.6100052064 5546617.425699662 270764.81861842854 1.0 3.314744736611683 0.16181326175778896 20.67427901438278 -6.709990083817334 1.7954182606098654 2.423141387615314 0.16933148366705847 0.46485052230314095 0.9754335572419993 0.3751651704117301 2.357466041924459 0.4323607319513865 1.0983394380032847 1.949889120784137e-07 6.709990083817334 -2.2538099039482553 HK(ub)ALDLDDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HKALDLDDR 9 1 D6REL5;Q6UWZ7-2;Q6UWZ7 D6REL5 FAM175A BRCA1-A complex subunit Abraxas 1 5745800.0 1180900.0 1416100.0 3148800.0 True False 1528698.3290190678 1337292.7901480563 2575750.7094163736 1.0 0.8747918178246246 1.6849306763285183 20.54387230488614 -6.867449297100229 1.147579443489312 0.930176807539557 1.7301169001126746 0.9620664354312107 0.06935192662625116 0.1393199118099718 0.3445230483832219 0.046971989568749276 0.11073559949653425 1.3569089371062618e-07 6.867449297100229 0.7999400925731176 HK(ub)ASVEDADTQSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HKASVEDADTQSK 13 1 Q13561;Q13561-3;Q13561-2;F8W1I6;H0YI98 Q13561 DCTN2 Dynactin subunit 2 1 3388590.0 716990.0 1348700.0 1322900.0 True False 694229.5449104836 1887242.9433775863 976392.8038506908 1.0 2.718471083827085 1.4064408681664367 19.40505323889583 -6.577757012556612 2.2755324392849725 2.1718179951251804 1.4095666876525208 0.0 0.7469808726558388 0.7062143864447646 6.874831061622698 0.2760127903215547 0.8355660575159749 2.643887596745521e-07 6.577757012556612 -0.7622513074726596 HK(ub)EAVMEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HKEAVMEVR 9 1 Q8WU76;Q8WU76-2;A0A087WUD7 Q8WU76 SCFD2 Sec1 family domain-containing protein 2 1 1792580.0 786580.0 1006000.0 0.0 True False 761610.4484521231 1407701.0462206965 0.0 1.0 1.8483216046755542 0.0 19.53869374539709 -6.790671414141873 1.5511558700679606 1.4786917665157098 1.0885186769710212e-19 0.7737281995820178 0.3593387307365995 0.2418868091029164 1.1588171221504067 0.1839776048349659 0.42024686641633446 1.6193047352241542e-07 6.790671414141873 -1.4786917665157098 HK(ub)EAVMEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HKEAVMEVR 9 1 Q8WU76;Q8WU76-2;A0A087WUD7 Q8WU76 SCFD2 Sec1 family domain-containing protein 2 1 3344880.0 786580.0 1336400.0 1221900.0 True False 654076.1214023228 1329200.547945371 1477393.64057273 1.0 2.032180207244989 2.258748778972752 19.319099020831366 -10.612550888602135 0.31040131307506125 1.3351073848472452e-15 2.322594722541396 0.9991288967863589 0.016169258729273276 2.2222938021259933 0.1518679924477206 1.7837435530020047 0.07786758186870014 2.4403331044352463e-11 10.612550888602135 2.3225947225413948 HK(ub)GYGFIEYEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HKGYGFIEYEK 11 1 A0A0J9YYL3;Q9UHX1-2;Q9UHX1-6;Q9UHX1-4;A0A0J9YVP6;Q9UHX1;Q9UHX1-5;Q9UHX1-3;A0A0J9YXX5;A0A0J9YXJ8;A0A0J9YVR6;E9PQ56;A0A0J9YWM1;H0YEM1;H0YCP8 A0A0J9YYL3 PUF60 Poly(U)-binding-splicing factor PUF60 1 14433500.0 1605700.0 3865400.0 8962400.0 True False 2435964.2923940835 3175589.1694919565 7190977.711640541 1.0 1.303627142404031 2.9520045651298097 21.216061554964337 -6.937986874318851 0.6780310908100724 0.9806950730812859 3.3713774568053623 0.9978881854626303 0.03941163482518519 0.08869711553072947 0.058882190904981174 0.0378026146812943 0.1431764125551866 1.1534881191631124e-07 6.937986874318851 2.3906823837240765 up HK(ub)LDVTSVEDYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HKLDVTSVEDYK 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 40645500.0 14430000.0 18971000.0 7244500.0 True False 18917869.74031879 16140600.748378806 6494908.634150998 1.0 0.8531933547453856 0.34332135294856675 24.17324630637152 -6.9481213381070255 0.579103331647255 1.006115398583483 0.16521912867287583 0.9990454724349032 0.008694428519682025 0.08424905226649541 0.03915318332379147 0.00911834959646514 0.0425821539970782 1.1268825709844739e-07 6.9481213381070255 -0.8408962699106072 down HK(ub)LDVTSVEDYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HKLDVTSVEDYK 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 43655000.0 15488000.0 14918000.0 13249000.0 True False 14996341.917702576 20874835.196342252 9778689.438519761 1.0 1.3919951486102322 0.6520716513522816 23.838107288878586 -6.762736031995526 1.6018866311783186 1.226908778176067 0.6489673776190111 0.7021820082875414 0.16494655174080688 0.2783250000203973 1.4081407759859588 0.08121674113564573 0.19467523951572321 1.7268871902888084e-07 6.762736031995526 -0.5779414005570559 HK(ub)LDVTSVEDYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HKLDVTSVEDYK 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 58777000.0 37657000.0 21120000.0 0.0 True False 57128422.095462486 17350970.98868681 0.0 1.0 0.30371871569799475 0.0 25.767705347004238 -8.733399181327021 0.49201129577528835 1.0757130688613836 8.172661136212146e-21 0.9948998678312246 0.02989458671331277 0.33910736542043585 0.19145630855688905 0.11431293612269137 0.061387917577562234 1.8475696465501355e-09 8.733399181327021 -1.0757130688613836 HK(ub)LDVTSVEDYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HKLDVTSVEDYK 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 37501900.0 14430000.0 13602000.0 9469900.0 True False 19765160.95608735 13001018.664201016 7233304.658712581 1.0 0.6577744898250835 0.36596234529953775 24.236456367894412 -7.464943744254142 0.2254046928108636 1.1593147339502614 1.5982949855566293e-14 0.9999261983369364 0.002226015410086763 0.12508900716312915 0.020180856233452674 0.026858287267563292 0.06227590866852354 3.428121893819047e-08 7.464943744254142 -1.1593147339502454 down HK(ub)LDVTSVEDYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HKLDVTSVEDYK 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 44106900.0 15488000.0 23853000.0 4765900.0 True False 12878958.234736688 23724499.154550202 5762427.654968142 1.0 1.842113214604679 0.4474296406541577 23.618512564312862 -6.743228640739233 1.6746107565343344 1.4991930790691748 0.44599095897768887 0.6193317789175048 0.3538105966451378 0.3120706757989137 1.7194905444152786 0.16705016874392745 0.4085243486516349 1.8062229629212518e-07 6.743228640739233 -1.0532021200914858 HK(ub)LDVTSVEDYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HKLDVTSVEDYK 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 77438000.0 37657000.0 25330000.0 14451000.0 True False 48747728.83044381 23920363.23314051 11821066.279781532 1.0 0.4906969782395652 0.2424947082334443 25.538831669096687 -9.666312056724438 0.19434898079546595 1.5498653134530729 1.433418896402426e-11 0.9995040169734356 0.007022261271638365 1.1073121064242992 0.08099713299122353 0.4895599392778309 0.14828802177425596 2.1561945464925363e-10 9.666312056724438 -1.5498653134387388 HK(ub)SETDTSLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HKSETDTSLIR 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 52839200.0 7480200.0 13510000.0 31849000.0 True False 11348010.275871102 11099034.9458882 25554031.190087374 1.0 0.9780600013632091 2.251851255759088 23.4359360263289 -6.9029820412694 0.942221537671093 0.9512859328222879 2.393959339848118 0.9879924416697861 0.06523972634544449 0.1092434754182827 0.16529817003470063 0.05162466740178289 0.13644428595035177 1.2503107313796732e-07 6.9029820412694 1.44267340702583 up HK(ub)SETDTSLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HKSETDTSLIR 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 55021200.0 7480200.0 10153000.0 37388000.0 True False 9683266.356785867 9587976.624795703 30583767.63327603 1.0 0.990159339991367 3.1584143724233558 23.20706234842135 -6.905877979651111 0.9233513019924601 0.9238052097978066 3.415255795330321 0.9892707856385967 0.10563425905107313 0.10720723800181198 0.1540210253912417 0.08475890471699914 0.22780028690587314 1.2420012140140455e-07 6.905877979651111 2.4914505855325144 up HK(ub)SIEEIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HKSIEEIVR 9 1 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 1 6200500.0 1315500.0 2084400.0 2800600.0 True False 1273740.172568293 2916711.790002402 2067038.843800924 1.0 2.2898797202268653 1.6228104352185668 20.28063958476988 -10.066338001998446 5.352668547186513 0.9999903832112618 1.956345077723685 0.7326543912467793 0.27232989522898643 3.125418003280528e-05 5.451228447197549e-06 0.263684931695576 0.08789409574086535 8.583452299602212e-11 10.066338001998446 0.9563546945124233 HK(ub)SIEEIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HKSIEEIVR 9 1 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 1 14012300.0 2922200.0 2713100.0 8377000.0 True False 4433191.041436133 2228926.1074529444 6721282.278230471 1.0 0.5027814246261049 1.5161273708730383 22.079914103853934 -6.77329261280844 1.5618355946774136 0.7160021187448692 1.522549142692565 0.7429616006231152 0.20975209844627354 0.2611594505426338 1.2576743066566372 0.10582813958988983 0.25116327771021396 1.6854170662155666e-07 6.77329261280844 0.8065470239476958 HK(ub)SIEEIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HKSIEEIVR 9 1 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 1 4031600.0 1136700.0 1445400.0 1449500.0 True False 1556968.7081624737 1381537.4487013798 1107157.9533895678 1.0 0.8873251218592973 0.711098397536987 20.570308518858354 -6.964553614895472 0.3656389485380162 1.01424002138631 0.5780911644406987 0.9999036352995349 0.0011670854191031558 0.07811284374619352 0.015396500774337116 0.002339366726635541 0.01500276512384179 1.0850415898776066e-07 6.964553614895472 -0.43614885694561134 HK(ub)SIEEIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HKSIEEIVR 9 1 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 1 6082800.0 1315500.0 3013500.0 1753800.0 True False 1093896.5365312565 2997265.677367085 2120511.4713450023 1.0 2.739990097117784 1.9384936331082459 20.061044860204156 -10.498812087831498 7.325676731626484 0.999714691044304 2.339241865113003 0.7882549919029916 0.32720956124472517 0.0015250231736223844 0.00010433403242258256 0.31687941842880024 0.10560643178505467 3.170939180143044e-11 10.498812087831498 1.339527174068699 HK(ub)TTGQVVAMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HKTTGQVVAMK 11 1 P06493;A0A024QZP7;P06493-2;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 3289850.0 641550.0 1536900.0 1111400.0 True False 841078.262779037 1307600.5107892794 996402.9893015974 1.0 1.5546716264771716 1.1846733335009114 19.681880524703086 -10.33230001375396 5.313025672465276 0.999895212385771 1.369672479989059 0.5709970225153462 0.15105117058216705 0.00018754272961940508 2.35688377734775e-05 0.1462958801793557 0.04875155567414686 4.652645743651293e-11 10.33230001375396 0.369777267603288 HK(ub)TTGQVVAMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HKTTGQVVAMK 11 1 P06493;A0A024QZP7;P06493-2;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 3203550.0 641550.0 1263600.0 1298400.0 True False 878748.3722368554 1207769.9738335838 991744.6613873855 1.0 1.3744207238292838 1.1285877649626797 19.745090586225977 -10.149441397132495 4.4256362579453 0.9999567204908854 1.2515042444052955 0.5825614308665414 0.10036088522850702 70201826.02291249 2.428668235331773 30961.46621140044 0.03435620045209179 7.088569518004747e-11 10.149441397132495 0.25154752391441015 HKLDVTSVEDYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HKLDVTSVEDYK 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 40007100.0 7421100.0 21384000.0 11202000.0 False True 9729133.96603464 18193590.55417913 10042924.49717157 1.0 1.8700113101222304 1.032252668349763 23.213879959272617 -10.305898134588098 5.063840509875335 0.9998621259670099 1.4511319892361083 0.27883291886667927 0.3420135333253255 0.0005325241098464334 7.299234464765449e-05 0.33125351357825805 0.11038439322882274 4.944266430248691e-11 10.305898134588098 0.45126986326909846 HKLDVTSVEDYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HKLDVTSVEDYK 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 24625300.0 8581700.0 3178600.0 12865000.0 False True 8309278.630885087 4447831.556180027 9495270.558272846 1.0 0.5352849210818019 1.1427310335917127 22.986291804344074 -6.702263732138081 1.8226531799525534 0.7120715331078954 1.1410100427562773 0.4283468728714257 0.19608241014377853 0.3908571073206902 2.5258854891539264 0.08577209902543784 0.21998065952957369 1.984889196191195e-07 6.702263732138081 0.42893850964838187 HKLDVTSVEDYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HKLDVTSVEDYK 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 100050000.0 14599000.0 70981000.0 14470000.0 False True 22147750.329863127 58313885.97291568 11609998.157573696 1.0 2.632948498353244 0.5242066568684065 24.400656827877576 -6.699967841546947 1.830718671300909 2.0140596389470087 0.530450320386005 0.41738697366604516 0.6892991866523697 0.39567657656421595 2.578088821355409 0.30036077735468303 0.772555506998098 1.9954100647742117e-07 6.699967841546947 -1.4836093185610038 HKLDVTSVEDYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HKLDVTSVEDYK 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 32462100.0 7421100.0 11925000.0 13116000.0 False True 10164881.21768676 11398114.069298446 10018270.9324992 1.0 1.1213228984383878 0.9855767832355523 23.27709002079551 -6.671071273380082 1.9335928889905263 1.0773706962465586 0.9861238404066969 0.28370024422601725 0.05152309561767753 0.45872060206121185 3.3074930742056456 0.021443947402753284 0.0572125810286493 2.1326948814219123e-07 6.671071273380082 -0.0912468558398617 HKLDVTSVEDYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HKLDVTSVEDYK 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 16533900.0 8581700.0 5229600.0 2722600.0 False True 7136063.783770652 5201427.1068056775 3291883.0721199107 1.0 0.7288930234389351 0.46130236105884415 22.76669707977835 -6.971286043035923 0.22536318006623113 1.11534095361729 0.06725071518868833 0.999990749439865 0.0006688679215342129 0.07588757424318958 0.007519561549337454 0.007116833256130297 0.026822325490811545 1.0683509904244709e-07 6.971286043035923 -1.0480902384286017 down HKLDVTSVEDYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HKLDVTSVEDYK 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 45650000.0 14599000.0 16814000.0 14237000.0 False True 18898693.289312698 15878286.119306108 11646012.083956094 1.0 0.8401790471029738 0.6162337208013197 24.171783149970025 -6.966364505191362 0.33380589170740727 1.0261008220051868 0.4229388642860634 0.9999385708120095 0.0012336312885601723 0.07750093183850794 0.013243716138298592 0.003224878412720337 0.019474248831208952 1.0805266800105865e-07 6.966364505191362 -0.6031619577191234 HKLDVTSVEDYK(ub)ALQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HKLDVTSVEDYKALQK 16 2 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 14017000.0 3234100.0 6906200.0 3876700.0 True False 3131435.26575684 9663881.675357219 2861275.971492913 1.0 3.0860870033095016 0.9137266871781775 21.57839262462423 -6.655366901528889 1.9892736499366752 2.3478638055378775 0.9228196766269051 0.21615093379653783 0.8891979705623454 0.49550477292764306 3.7642874740804846 0.3617538850489055 0.9853296354328936 2.2112258280740256e-07 6.655366901528889 -1.4250441289109723 HKLDVTSVEDYK(ub)ALQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HKLDVTSVEDYKALQK 16 2 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 36164400.0 9892400.0 11241000.0 15031000.0 True False 15007494.031312978 9234955.723666128 12060116.26167867 1.0 0.6153562816281979 0.8036062674098263 23.839179758396778 -10.10450095122282 5.050110083881151 1.0000087258007586 0.7094812745182079 0.7605098093566511 0.07685273487798983 7.550638357076282e-06 1.3387716738060936e-06 0.07441457523501803 0.02480411352401207 7.861384692895708e-11 10.10450095122282 -0.29052745128255075 HKLDVTSVEDYK(ub)ALQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HKLDVTSVEDYKALQK 16 2 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 9750600.0 3022400.0 3845500.0 2882700.0 True False 4139862.957288874 3675593.094632043 2201865.6310700974 1.0 0.887853808822485 0.5318692076976533 21.98115158001686 -6.95017459153171 0.5569234613463006 1.0047329522440687 0.39806658726885596 0.9992149136515877 0.005591784872406002 0.08341570558953094 0.035672793487952555 0.006016594576655329 0.029572583266337257 1.1215674802326613e-07 6.95017459153171 -0.6066663649752126 HKLDVTSVEDYK(ub)ALQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HKLDVTSVEDYKALQK 16 2 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 11193600.0 3234100.0 5098200.0 2861300.0 True False 2689297.4449226465 5070734.984686538 3459584.6008435646 1.0 1.8855240405853988 1.2864269095169107 21.358797900058505 -10.280466021654748 5.67532319810221 0.9999516617581626 1.5859754750511619 0.5605490063204067 0.2445803795805424 0.00014960336525530113 1.8966789925099714e-05 0.23683337183347355 0.07893797807704012 5.242446152706029e-11 10.280466021654748 0.5860238132929992 HKLDVTSVEDYK(ub)ALQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HKLDVTSVEDYKALQK 16 2 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 45184400.0 9892400.0 14012000.0 21280000.0 True False 12805906.808356537 13232219.882462079 17407258.3512387 1.0 1.0332903464382037 1.3593147765123152 23.610306080489227 -6.926537092301903 0.7746740877033735 0.9943544923624879 1.4207057811043606 0.9958131855774859 0.010489210394228806 0.09447561833186295 0.08677937248491784 0.009366298640006982 0.030080652352628443 1.1843032134938379e-07 6.926537092301903 0.4263512887418728 HKSETDTSLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HKSETDTSLIR 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 17291000.0 3090800.0 8573800.0 5626400.0 False True 4052068.731349774 7294622.460410641 5044234.100239788 1.0 1.8002217987997324 1.244854032512799 21.950227214721 -10.224449723351972 5.567983338972633 0.999974890031059 1.5225379156562853 0.5413593023266627 0.22672794116546252 7.067902793096543e-05 9.844620914202789e-06 0.21953891211231025 0.07317612835446487 5.964173608451675e-11 10.224449723351972 0.5225630256252263 HKSETDTSLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HKSETDTSLIR 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 58411200.0 10002000.0 38827000.0 9582200.0 False True 15173765.244146261 31898018.493264407 7688273.969972543 1.0 2.102182153211447 0.5066820163794564 23.855075787043457 -6.720862976298216 1.7562379799424124 1.6699412334726305 0.5090545441035232 0.5165543509743418 0.4637545188451072 0.35365388944444204 2.1322476473255483 0.2096316860141461 0.5257149825541345 1.9016781813550445e-07 6.720862976298216 -1.1608866893691072 HKSETDTSLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HKSETDTSLIR 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 16976700.0 3090800.0 6550700.0 7335200.0 False True 4233552.285729363 6261268.4137319345 5602776.833186043 1.0 1.4789632892542 1.323422141748933 22.01343727624389 -9.970949252008907 4.7803730519299705 0.9999954676914998 1.4011927153648196 0.8986892911434009 0.0634994076280508 10451055.77724837 10899456.952511648 431.08479786659876 0.021737537514011567 1.0691798072602249e-10 9.970949252008907 0.40119724767331977 HKSETDTSLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HKSETDTSLIR 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 26402600.0 10002000.0 6998500.0 9402100.0 False True 12947786.16889553 6609027.322824078 7691014.273692735 1.0 0.5104368605268557 0.5940022621140331 23.626202109135907 -10.789793560712766 7.153413288262551 1.0140401446246747 0.5522195613204444 0.9745442662028482 0.03411543233989136 0.007478633086048127 0.00021976284601348125 0.0323385914798404 0.011010708441755421 1.6225811983536367e-11 10.789793560712766 -0.46182058330423037 HLAAVEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLAAVEER 8 0 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 0 3219780.0 487280.0 1663500.0 1069000.0 False True 638828.7988262324 1415312.2842722125 958390.1345720775 1.0 2.2154797762290475 1.500230008936665 19.28506982630191 -10.135365047921624 4.814196676321094 0.9999419530107857 1.857854892586486 0.657300738156847 0.2919994947706932 0.00018493896729762437 3.3215083001833515e-05 0.2827466144570202 0.09424243169296412 7.322088134267378e-11 10.135365047921624 0.8579129395757003 HLAAVEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLAAVEER 8 0 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 0 3016380.0 487280.0 1334300.0 1194800.0 False True 667440.5842468634 1275346.2140599503 912612.8476784119 1.0 1.910801117224606 1.3673319681454488 19.348279887824802 -10.07659570581668 4.658463286194799 0.9999695407591943 1.6390665426671658 0.648340662728497 0.2218703510882957 116475843.76106916 3.5805249172134928 39865.27255163687 0.08119623442043569 8.383093193804898e-11 10.07659570581668 0.6390970019079715 HLAEHSPYYEAMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLAEHSPYYEAMK 13 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 6327900.0 1293500.0 2953100.0 2081300.0 False True 1695791.02627182 2512508.9910936407 1865947.0412393499 1.0 1.4816147462564224 1.100340202496304 20.6935269656777 -9.940780084109472 4.989642946577064 0.9999984908590362 1.2909774743834608 0.4371182978973728 0.1556546807120605 2.6132003702549168e-06 5.545154883597744e-07 0.15071277801837776 0.050237332176234675 1.1460931475084996e-10 9.940780084109472 0.29097898352442453 HLAEHSPYYEAMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLAEHSPYYEAMK 13 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 5777100.0 1339000.0 1054600.0 3383500.0 False True 1296494.1779315427 1475707.2796663477 2497259.8471757597 1.0 1.1382290061809037 1.92616356454446 20.3061842969283 -6.936929654475314 0.6875375784586549 0.9905122951886438 2.120731175309926 0.9977334150140929 0.019421424027170765 0.08919569875590314 0.06120094823871423 0.01849138059133056 0.06878330852759713 1.1562995204389507e-07 6.936929654475314 1.130218880121282 HLAEHSPYYEAMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLAEHSPYYEAMK 13 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 26763400.0 3353100.0 18503000.0 4907300.0 False True 5086897.844445793 15200995.085401144 3937370.0040540057 1.0 2.9882642723007664 0.774021835007574 22.278354691480036 -6.6700619053049675 1.9369841741771987 2.2690627982142733 0.7829559293140614 0.2792711123384437 0.8445660470781146 0.46105369274341845 3.3349644556662645 0.35099795397806755 0.9377607129375027 2.1376573613320507e-07 6.6700619053049675 -1.4861068689002117 HLAEHSPYYEAMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLAEHSPYYEAMK 13 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 7502900.0 1293500.0 2792700.0 3416700.0 False True 1771741.9055231458 2669309.279776076 2609745.8291453216 1.0 1.5066016508696303 1.472983068814832 20.756737027200593 -10.170463904350926 4.95072046366957 0.9999617001510538 1.489792359843261 0.9964790142389992 0.013724728655284768 5.802536351331718e-06 9.722695769799375e-07 0.013289947869965044 0.004429637125581027 6.7536118316148e-11 10.170463904350926 0.4898306596922072 HLAEHSPYYEAMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLAEHSPYYEAMK 13 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 4642800.0 1339000.0 1888900.0 1414900.0 False True 1113437.8277577744 1878724.1207827074 1710749.048241556 1.0 1.687318388100803 1.5364567339037138 20.086589572362577 -10.16438645189958 5.073680364166315 0.9999647600723457 1.6118875610030083 0.956397232056836 0.061589012425119515 2.4552021001821316e-05 4.043752172339237e-06 0.05963672914376472 0.019877768285613568 6.848785240261212e-11 10.16438645189958 0.6119228009306626 HLAEHSPYYEAMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLAEHSPYYEAMK 13 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 11333800.0 3353100.0 3714000.0 4266700.0 False True 4340654.049482463 3507312.635131611 3490204.3800390125 1.0 0.8080147819082215 0.8040733816267045 22.049481013572485 HLAGEVAK(ub)EWQELDDAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLAGEVAKEWQELDDAEK 18 1 Q13200;Q13200-3 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 16226700.0 3938100.0 4243700.0 8044900.0 True False 3813087.171106954 5938231.540603148 5937699.348173274 1.0 1.5573290811705351 1.5571895112089809 21.862528082262365 -10.078284998611766 4.607516639681868 0.9999684331388388 1.5572592962074026 0.9999999524700212 5.697925863875423e-05 39577.195316442616 0.001256459049423044 13.25462545114006 1.950550674866356e-05 8.350548473757724e-11 10.078284998611766 0.5572908630685638 HLAGEVAK(ub)EWQELDDAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLAGEVAKEWQELDDAEK 18 1 Q13200;Q13200-3 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 59835900.0 8596900.0 19281000.0 31958000.0 True False 13042125.81757659 15840154.906859428 25641487.29231099 1.0 1.2145378083618847 1.9660512136567885 23.636675706826146 -6.947924744422428 0.5811794108965842 0.9910559756921311 2.2267795575238183 0.9990282110251019 0.012912070908284251 0.08432990161678708 0.039494592804385636 0.013511276290644084 0.06279855812548597 1.1273927965474263e-07 6.947924744422428 1.2357235818316872 HLAGEVAK(ub)EWQELDDAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLAGEVAKEWQELDDAEK 18 1 Q13200;Q13200-3 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 13720800.0 3938100.0 4001200.0 5781500.0 True False 3274704.637410675 3979644.7414239882 6990384.919364302 1.0 1.2152683011346979 2.1346611964649225 21.64293335769664 -6.943372720743124 0.6274122435170053 0.9899691839184938 2.409290370481783 0.9985730252829993 0.01858760469896945 0.08626130853044771 0.04785380015379211 0.018594574890614658 0.07803137657689095 1.1392716207912205e-07 6.943372720743124 1.4193211865632893 up HLAGEVAK(ub)EWQELDDAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLAGEVAKEWQELDDAEK 18 1 Q13200;Q13200-3 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 63989900.0 8596900.0 19966000.0 35427000.0 True False 11128856.520233758 18854874.548475444 28979649.511716835 1.0 1.6942328723705573 2.604009626598019 23.407802028918596 -6.967404557121782 0.31405713976519845 0.8663898762342 3.4609426823111544 0.9999544781826508 0.004431430062444272 0.07715419666188382 0.01203033339380162 0.014138335948799569 0.08045961429091901 1.0779421219918759e-07 6.967404557121782 2.5945528060769543 HLAGLFNSITSFYHPSNNGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLAGLFNSITSFYHPSNNGR 20 0 Q14997;F8WBH5 Q14997 PSME4 Proteasome activator complex subunit 4 0 65196400.0 13198500.0 22129900.0 29868000.0 False True 17303361.31445583 18828205.18167457 26777545.874086797 1.0 1.088124141865132 1.547534342458416 24.04454898419223 -6.938878362940705 0.6699199172336064 0.9947297268164857 1.6674379006936393 0.9980132340035902 0.010699798654811726 0.08828210740495837 0.0569685640445984 0.010328973794364732 0.0397399125820544 1.1511227498897944e-07 6.938878362940705 0.6727081738771535 HLAGLFNSITSFYHPSNNGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLAGLFNSITSFYHPSNNGR 20 0 Q14997;F8WBH5 Q14997 PSME4 Proteasome activator complex subunit 4 0 146732900.0 60686000.0 46347000.0 39699900.0 False True 58759556.14783693 64853598.796412066 29301305.218528986 1.0 1.1037115160169477 0.4986645090512249 25.80832016245881 -6.862748083100521 1.1718697626632746 1.0567282307959205 0.4678032444419555 0.9568885407609619 0.054854910338898055 0.1439920839082597 0.37421226447942874 0.03646834374095546 0.08540321093646269 1.3716771906503772e-07 6.862748083100521 -0.588924986353965 down HLAGLFNSITSFYHPSNNGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLAGLFNSITSFYHPSNNGR 20 0 Q14997;F8WBH5 Q14997 PSME4 Proteasome activator complex subunit 4 0 171951000.0 63566000.0 48400000.0 59985000.0 False True 96434269.2970807 39762641.849073954 48128938.457640536 1.0 0.4123289587706522 0.49908542687633056 26.523042584103298 -10.737928531929372 6.954100970723485 1.0081914567892243 0.45570719282349137 0.9813016898953809 0.03541817979082586 0.00448853127066436 0.00016915408767988644 0.034220463426707134 0.011431168373570725 1.828401075470757e-11 10.737928531929372 -0.5524842639657329 HLAGLFNSITSFYHPSNNGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLAGLFNSITSFYHPSNNGR 20 0 Q14997;F8WBH5 Q14997 PSME4 Proteasome activator complex subunit 4 0 86506500.0 13198500.0 27882000.0 45426000.0 False True 18078342.126051214 26650081.046555884 34697314.377836905 1.0 1.4741440813951985 1.9192752375140338 24.10775904571512 -6.971887687268731 0.2082250871750577 0.761605409780134 2.644215531197527 0.9999936018191132 0.0009494284693183069 0.0756948411224742 0.006792862371680312 0.013519412392998104 0.04631767551442904 1.0668719889181682e-07 6.971887687268731 1.8826101214173927 HLAGLFNSITSFYHPSNNGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLAGLFNSITSFYHPSNNGR 20 0 Q14997;F8WBH5 Q14997 PSME4 Proteasome activator complex subunit 4 0 124668000.0 60686000.0 34514000.0 29468000.0 False True 50463097.8456373 34328066.231507346 35629622.555362366 1.0 0.6802607786092372 0.706053018472045 25.588725437893086 -10.775981605980066 6.997436797811975 1.008305423278255 0.6931568985411015 0.9947287760713648 0.010529637831225225 0.0013766249605413803 4.4071697939230415e-05 0.010287234033988592 0.0033984259968275715 1.6750138177178028e-11 10.775981605980066 -0.3151485247371534 HLAGLFNSITSFYHPSNNGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLAGLFNSITSFYHPSNNGR 20 0 Q14997;F8WBH5 Q14997 PSME4 Proteasome activator complex subunit 4 0 117260000.0 63566000.0 22935000.0 30759000.0 False True 82287440.07318668 21658647.088514682 25161177.613992114 1.0 0.26320720475994175 0.30577178718421294 26.294168906195747 -10.21457872294975 6.254410477791194 1.0000087552523735 0.2844894959720767 0.997352872371737 0.01737691800902103 2.1214763708116464e-06 2.6641770106608334e-07 0.016825334079633263 0.005608376171445245 6.101284508993542e-11 10.21457872294975 -0.7155192592802968 HLAGLGLTEAIDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLAGLGLTEAIDK 13 0 P50454;E9PKH2 P50454 SERPINH1 Serpin H1 0 4272800.0 1306900.0 1450100.0 1515800.0 False True 1713358.5560376036 1233750.7324455276 1358959.5565803142 1.0 0.7200773755720808 0.7931553799941969 20.708395666389404 -9.780941594283847 5.721505581462358 1.0000000257894381 0.7566163777813244 0.936666030560373 0.02983397038225971 9.813887895594691e-09 2.0312825331400222e-09 0.028886620620733754 0.009628872535875995 1.655992653228579e-10 9.780941594283847 -0.24338364800811374 HLAGLGLTEAIDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLAGLGLTEAIDK 13 0 P50454;E9PKH2 P50454 SERPINH1 Serpin H1 0 5894600.0 1306900.0 2536600.0 2051100.0 False True 1790096.2476445287 2424524.624585528 1566672.4237304912 1.0 1.354410204353985 0.8751889323224791 20.771605727912295 -6.708606083529181 1.799973284545561 1.2181999072010603 0.8763541611571748 0.4584368057135414 0.14938090733835854 0.3779545295998825 2.386105867112778 0.06606153375677602 0.16812424788126418 1.9561128970101953e-07 6.708606083529181 -0.3418457460438855 HLAGVPLIGWVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLAGVPLIGWVLR 13 0 Q8NFW8;F5H296;Q8NFW8-2 Q8NFW8 CMAS N-acylneuraminate cytidylyltransferase 0 8365830.0 2434970.0 4061800.0 1869060.0 False True 3192269.250283021 3455795.2727723955 1675667.6004895105 1.0 1.0825513143874097 0.5249142441042367 21.60615090937628 -6.869243846457303 1.1380125052607115 1.0464864737619695 0.492711615838735 0.963926621344374 0.046672821332911105 0.13758594398223972 0.33348490166530553 0.03184194359905179 0.07529397222166205 1.3513136183386088e-07 6.869243846457303 -0.5537748579232344 HLAGVPLIGWVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLAGVPLIGWVLR 13 0 Q8NFW8;F5H296;Q8NFW8-2 Q8NFW8 CMAS N-acylneuraminate cytidylyltransferase 0 29384300.0 11525800.0 7318900.0 10539600.0 False True 11159919.787903951 10241374.937559286 7778962.578777485 1.0 0.9176925221863816 0.6970446675798665 23.411823322022986 -6.953948823243737 0.5136665712804384 1.0039414860488498 0.601054832496962 0.9994758417155134 0.002928362789395123 0.08193777800123485 0.029691992078099923 0.0033519402838400976 0.018215430256437716 1.1118627401734186e-07 6.953948823243737 -0.4028866535518878 HLAGVPLIGWVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLAGVPLIGWVLR 13 0 Q8NFW8;F5H296;Q8NFW8-2 Q8NFW8 CMAS N-acylneuraminate cytidylyltransferase 0 45242800.0 13025400.0 13966000.0 18251400.0 False True 19760484.0842934 11473658.183143942 14644002.790127201 1.0 0.5806364932255768 0.741075103608771 24.23611495412274 -10.09433620411829 4.998180455808714 1.0000100858686762 0.6608557984158142 0.8562774922725069 0.06549878841805153 7.361606235486098e-06 1.3339818466500102e-06 0.06342081364682352 0.02113964306098189 8.047552079329781e-11 10.09433620411829 -0.339154287452862 HLAGVPLIGWVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLAGVPLIGWVLR 13 0 Q8NFW8;F5H296;Q8NFW8-2 Q8NFW8 CMAS N-acylneuraminate cytidylyltransferase 0 19956970.0 2434970.0 5883500.0 11638500.0 False True 3335244.211590018 5623547.51586728 8889726.00243152 1.0 1.6860976765435578 2.665389830087885 21.66936097089917 -6.966069282882118 0.33919997113905404 0.8927925133666622 3.4912001599066462 0.999933520529057 0.005572059548543888 0.07759995769853545 0.01359077265799511 0.013858134062680551 0.08481179297036345 1.0812614441903553e-07 6.966069282882118 2.598407646539984 HLAGVPLIGWVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLAGVPLIGWVLR 13 0 Q8NFW8;F5H296;Q8NFW8-2 Q8NFW8 CMAS N-acylneuraminate cytidylyltransferase 0 25875700.0 11525800.0 7287000.0 7062900.0 False True 9584213.379514989 7247743.484643744 8539719.734840129 1.0 0.7562168325816759 0.8910193666068277 23.192228597457262 -10.252619295668303 4.800653675893871 1.0000455551590426 0.8236180995939324 0.6953735971251017 0.05503290406707012 2.6839481256527348e-05 4.178432419457403e-06 0.05329912898643879 0.017761793411942346 5.589599666465511e-11 10.252619295668303 -0.1764274555651102 HLAGVPLIGWVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLAGVPLIGWVLR 13 0 Q8NFW8;F5H296;Q8NFW8-2 Q8NFW8 CMAS N-acylneuraminate cytidylyltransferase 0 37519500.0 13025400.0 14824500.0 9669600.0 False True 16861637.06901937 13999503.543217197 7909832.018474523 1.0 0.8302576722481534 0.46910225775216136 24.00724127621519 -6.958816902504529 0.451801773797251 1.011434406162758 0.27356515110212914 0.9997237621642869 0.0036794879725588086 0.0801265304680966 0.02271383078692174 0.004840345830792714 0.029865695413736106 1.099469275301701e-07 6.958816902504529 -0.737869255060629 down HLCAVYYNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLCAVYYNK 9 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 36074000.0 11112000.0 13253000.0 11709000.0 False True 14567939.608761065 11275704.05978938 10497465.000658968 1.0 0.7740081550728178 0.720586801056332 23.79629351097435 -13.999999999999998 0.20261150850865803 2.2689325476097117 0.6867717971502311 0.9994872262397818 0.0027423581691519063 12.583764421602929 0.1427152268537664 6.335068055245059 0.03336533127677792 1.0000000000000041e-14 13.999999999999998 -1.5821607504594808 HLCAVYYNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLCAVYYNK 9 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 51635000.0 19047000.0 18927000.0 13661000.0 False True 28895691.522220954 15549328.972674053 10960897.362170987 1.0 0.5381192888468002 0.3793263557559089 24.784351060643168 -13.999999999999991 0.14898130770572376 3.229956565737921 0.20255979419069267 0.9995696756201997 0.00546127264299712 11.954043280753556 0.12150681137600698 7.719259231915371 0.15917296301511016 1.0000000000000205e-14 13.999999999999991 -3.0273967715472283 HLCAVYYNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLCAVYYNK 9 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 33082100.0 11112000.0 8261100.0 13709000.0 False True 15220406.690508828 7896097.286195489 10471216.545717556 1.0 0.5187835940756664 0.6879721914557788 23.859503572497243 -10.26316797543137 6.122892919277461 1.0000122133029006 0.6033778927657222 0.8799146179922764 0.06907095564641196 1.151590933861216e-05 1.3859767061156775e-06 0.06687972214378121 0.022292555077098396 5.455468149243685e-11 10.26316797543137 -0.3966343205371784 HLCAVYYNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLCAVYYNK 9 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 51237000.0 19047000.0 14718000.0 17472000.0 False True 24656716.972500827 13898930.36183821 14292275.277859159 1.0 0.5636975262091635 0.5796503765606372 24.555477382735617 -9.848696906445698 6.6617396278674805 1.0000000091641499 0.5716739513984989 0.998960707914361 0.006512723884099574 8.873043505452888e-10 1.4810512153295988e-10 0.006305917926301843 0.0021019725951179073 1.4167822054657877e-10 9.848696906445698 -0.428326057765651 HLDLASLK(ub)SIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLDLASLKSIR 11 1 Q8NBN7;Q8NBN7-2;G8JLA1;K7EMY5 Q8NBN7 RDH13 Retinol dehydrogenase 13 1 1936550.0 1149800.0 786750.0 0.0 True False 1507398.9346790381 669369.9667274797 0.0 1.0 0.4440562822011048 0.0 20.5236298475191 -8.114384181553271 0.5603758785140839 1.02100423896106 5.94077319074084e-17 0.9905153040546609 0.03984192671368783 0.11730247659126883 0.16957943695803943 0.04983406066292518 0.074516987449915 7.684503601033843e-09 8.114384181553271 -1.02100423896106 HLDLASLK(ub)SIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLDLASLKSIR 11 1 Q8NBN7;Q8NBN7-2;G8JLA1;K7EMY5 Q8NBN7 RDH13 Retinol dehydrogenase 13 1 7579980.0 815280.0 1846500.0 4918200.0 True False 789399.3826617097 2583817.079370289 3629975.877162645 1.0 3.273143020023822 4.598402224388665 19.590395865429624 -8.555370644230798 0.2641128892104311 1.7015682896951732e-15 5.51322625563624 0.9991572634655801 0.043136542186349075 0.19380933189404442 0.073912129832273 0.6399460240357346 0.489292811464753 2.7837443960726704e-09 8.555370644230798 5.513226255636238 HLDLASLK(ub)SIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLDLASLKSIR 11 1 Q8NBN7;Q8NBN7-2;G8JLA1;K7EMY5 Q8NBN7 RDH13 Retinol dehydrogenase 13 1 6547480.0 815280.0 1856700.0 3875500.0 True False 677941.4430279009 1846697.5885739052 4685849.131712594 1.0 2.723978018405203 6.911878864912152 19.3708011408639 -6.956074248255257 0.48762239037746025 0.90634507804057 8.906383581914328 0.9995957597396721 0.04991051840882766 0.08113444620617487 0.026548457579080125 0.05999103238113888 0.3454091181041445 1.1064346085093246e-07 6.956074248255257 8.000038503873759 HLDVMDLSK(ub)NQIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLDVMDLSKNQIR 13 1 H3BSW0;A0A3B3ISV5;Q8N9N7 H3BSW0 LRRC57 Leucine-rich repeat-containing protein 57 1 10814800.0 2895800.0 4937400.0 2981600.0 True False 2803874.4140807823 6908929.568200862 2200629.513917318 1.0 2.4640652710780824 0.7848530957256761 21.41899030161123 -6.676242712315345 1.9150067851572703 1.9294194743021404 0.7913812801271974 0.307125014380221 0.6210186275315459 0.4469179050092334 3.1653398263480463 0.2605153991247408 0.690475096709727 2.1074500390949764e-07 6.676242712315345 -1.1380381941749431 HLEEK(ub)QLSEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLEEKQLSEGK 11 1 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 1 2262770.0 523490.0 517380.0 1221900.0 True False 506872.0964939392 723972.5321010577 901847.7337857417 1.0 1.4283140403837842 1.779241232697301 18.951262219627058 -6.97340245823815 0.15689244889100312 0.6293199906755974 2.5875205707952156 0.9999982248890752 0.00042450380857785215 0.07521329947924542 0.004827982637401567 0.016735906410818447 0.042604613594430615 1.0631573396945747e-07 6.97340245823815 1.9582005801196183 HLEEK(ub)QLSEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLEEKQLSEGK 11 1 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 1 2141010.0 523490.0 992160.0 625360.0 True False 435305.1295391475 986815.0371516588 756119.884662053 1.0 2.2669501694050527 1.7369882258510216 18.731667495061334 -9.920816983107336 5.600387627664343 0.9999990942486638 2.0019691976300646 0.8265708895134506 0.21635605747399203 2.4467207876518286e-06 4.7155013605286256e-07 0.2094860422459213 0.06982861728628258 1.2000048930356419e-10 9.920816983107336 1.0019701033814008 HLEEQIAK(ub)VDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLEEQIAKVDR 11 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 8260700.0 1316500.0 6944200.0 0.0 True False 1704235.202094678 6557749.1655576145 0.0 1.0 3.8479132208379894 0.0 20.700693025474397 -6.708491794637891 1.8010835529592188 2.75353988739298 0.009618389349576784 0.45778522610166716 1.2003784411491165 0.3780737422762694 2.389888251523939 0.5306265635471701 1.3502584435922618 1.9566277352188502e-07 6.708491794637891 -2.7439214980434032 HLEFSHDQYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLEFSHDQYR 10 0 Q9NR45 Q9NR45 NANS Sialic acid synthase 0 3614100.0 662900.0 1735700.0 1215500.0 False True 869068.3195327328 1476740.3257056093 1089731.7198993068 1.0 1.699222365509308 1.2539080017152355 19.729110069631588 -10.213382694886539 3.9110797925221386 0.9996228142484486 1.47656518354466 0.6042798477648263 0.18179882862596747 128979944.26183319 294281818.86782 675032.875945386 0.06653157153299348 6.1181103386153e-11 10.213382694886539 0.4769423692962115 HLEFSHDQYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLEFSHDQYR 10 0 Q9NR45 Q9NR45 NANS Sialic acid synthase 0 2995100.0 597760.0 542640.0 1854700.0 False True 578784.4359972808 759318.9818302159 1368898.430192666 1.0 1.3119201806487129 2.365126539441184 19.142666601538927 -6.948766772577186 0.572221086323793 0.987008483461299 2.7414401917491675 0.9991009287006135 0.017512680994674623 0.0839847264515152 0.03804096229990529 0.018506956075786524 0.08780121775401971 1.1252090782584438e-07 6.948766772577186 1.7544317082878687 up HLEFSHDQYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLEFSHDQYR 10 0 Q9NR45 Q9NR45 NANS Sialic acid synthase 0 11420700.0 1918000.0 7658300.0 1844400.0 False True 2909746.2245823317 6291616.530429 1479853.531570761 1.0 2.1622561023623654 0.5085850852107149 21.472461902354013 -6.717771331402698 1.7668727646375944 1.7087573189277905 0.511398510554952 0.5021860321401357 0.48921921751616976 0.3596673829493193 2.1930411415553546 0.21993230239854167 0.553661267101462 1.915264101487815e-07 6.717771331402698 -1.1973588083728384 HLEFSHDQYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLEFSHDQYR 10 0 Q9NR45 Q9NR45 NANS Sialic acid synthase 0 3890100.0 662900.0 1612700.0 1614500.0 False True 907992.0441989129 1541445.5815142614 1233188.3516712368 1.0 1.6976421669798005 1.358148851138043 19.79232013115448 -10.084743463291234 4.4120745572125815 0.999952943126434 1.5278955090985986 0.7632480810832867 0.13859756595491166 20885734.61107097 23869419.986160878 7826.315714520512 0.04744563524058466 8.227284901863769e-11 10.084743463291234 0.5279425659721646 HLEFSHDQYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLEFSHDQYR 10 0 Q9NR45 Q9NR45 NANS Sialic acid synthase 0 1887370.0 597760.0 853380.0 436230.0 False True 497063.92525801883 848782.672557332 527443.6761003699 1.0 1.7075925840257689 1.0611183980542973 18.923071876973204 -10.222298960953397 4.457636469021718 0.9998687727166446 1.384355491045775 0.3203315176785494 0.26392198127135147 0.0003443136134433109 6.006958990068267e-05 0.25562812837452803 0.08518045317743692 5.993783323335186e-11 10.222298960953397 0.3844867183291303 HLEFSHDQYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLEFSHDQYR 10 0 Q9NR45 Q9NR45 NANS Sialic acid synthase 0 7740600.0 1918000.0 2768400.0 3054200.0 False True 2482888.809432272 2614336.1063808193 2498366.9387384066 1.0 1.0529412740712314 1.0062339196372123 21.243588224446462 -6.616017732269561 2.131851314218587 1.03522647979263 1.00640960578738 0.06943232839285751 0.022789967394626305 0.5961782373714546 5.143128233328285 0.008802073215613306 0.025274526449693628 2.4209301979940276e-07 6.616017732269561 -0.028816874005250126 HLEINPDHPIVETLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLEINPDHPIVETLR 15 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 440933600.0 40468600.0 229536000.0 170929000.0 False True 53054726.49847994 195290123.52432024 153242906.7467451 1.0 3.6809184857434984 2.8883931151946594 25.660977946777976 -10.221427504881555 5.685352525561336 0.9999144228940972 3.284655800469139 0.9172210235223256 0.32354712767602195 0.0003509739004921277 4.8061399256763954e-05 0.31328449488241744 0.10442438643350796 6.005822534413642e-11 10.221427504881555 2.284741377575042 HLEINPDHPIVETLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLEINPDHPIVETLR 15 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 274273000.0 60561900.0 75900400.0 137810700.0 False True 58639395.63440799 106207825.53535719 101713943.43761924 1.0 1.811202594882089 1.734566707879511 25.80536689865639 -10.097698449496741 4.44656773319799 0.9999256520671785 1.7728846514180816 0.9926800922801177 0.03128647000890131 10886562.056990514 1.3105256500838538 8377.238624479854 0.010710190832752013 7.985489638500974e-11 10.097698449496741 0.7729589993509031 HLEINPDHPIVETLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLEINPDHPIVETLR 15 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 621550800.0 5819000.0 565651000.0 50080800.0 False True 8827848.425883526 464706159.5985649 40182307.928805545 1.0 52.640930969774246 4.551766862125744 23.073630428087206 -9.800034660661339 13.119638389670722 1.0000045620483358 28.59634890947809 0.3051134929657203 19.632319036783837 0.0 0.0 19.00891173573071 6.3363037172047285 1.584766708574132e-10 9.800034660661339 27.596344347429753 HLEINPDHPIVETLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLEINPDHPIVETLR 15 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 346412400.0 40468600.0 160950200.0 144993600.0 False True 55430935.042793974 153838887.9728636 110749097.91692707 1.0 2.7753255082941757 1.9979655373200214 25.724188008300867 -10.107635249129986 4.7879394146835565 0.9999371907290302 2.386645522813061 0.8092525360734197 0.3173558793371758 83558161.69805753 10.372033235954836 68190.9761910359 0.11614035965475132 7.804853414885118e-11 10.107635249129986 1.3867083320840308 HLEINPDHPIVETLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLEINPDHPIVETLR 15 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 115640700.0 60561900.0 27559300.0 27519500.0 False True 50359903.1970751 27410832.580807254 33273700.214208435 1.0 0.5442987543788462 0.660718113059061 25.585772174090668 -10.094654971052744 7.514761738919987 1.0000000624993837 0.6025084337189653 0.9395526900851237 0.04752800415809703 4.975899606056128e-08 6.022602187878417e-09 0.04601879900297711 0.01533959738189888 8.041647439975563e-11 10.094654971052744 -0.3974916287804183 HLEINPDHPIVETLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLEINPDHPIVETLR 15 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 119310800.0 5819000.0 56420900.0 57070900.0 False True 7532810.209638375 53281027.31704292 46684581.79688486 1.0 7.073193912262495 6.19749874185746 22.844756750179656 -10.108583871906857 6.107094727503024 0.9999797251395343 6.635346327060063 0.9822118364689919 0.3575010562856218 9.868935602326278e-05 1.4408891606297397e-05 0.3461501391365048 0.11538296977043634 7.787823998576408e-11 10.108583871906857 5.635366601920529 HLEINPDHSIIETLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLEINPDHSIIETLR 15 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 174207200.0 26058600.0 86517100.0 61631500.0 False True 34163076.951841354 73609085.92101444 55254463.5910935 1.0 2.154638647589587 1.6173737415099942 25.025934583644446 -10.145896114357754 5.487225178785587 0.9999817707153956 1.8860061945499629 0.7838334515844999 0.21933747943382897 4.8916235684903116e-05 7.614184503198615e-06 0.2123769601268554 0.07079086708710627 7.14667257991856e-11 10.145896114357754 0.8860244238345673 HLEINPDHSIIETLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLEINPDHSIIETLR 15 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 138633600.0 34327800.0 33122100.0 71183700.0 False True 33238082.779087678 46347927.2594697 52538553.50477462 1.0 1.394422402986201 1.5806734056824172 24.986333831973422 -11.427436676899404 0.1319408541796517 1.6935439496289305e-19 1.8793591405555112 0.9997231561871809 0.004027933308821743 4.153192426338495 0.08459772949930448 1.4225864264100445 0.21490928678977128 3.737346144680317e-12 11.427436676899404 1.8793591405555112 HLEINPDHSIIETLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLEINPDHSIIETLR 15 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 347657500.0 41824600.0 268959900.0 36873000.0 False True 63450975.98783431 220961904.45170993 29585035.387989953 1.0 3.4824035566304885 0.4662660412609319 25.91913901964087 -6.68805146442237 1.8733385778771614 2.559156832092576 0.47693295134977143 0.36129322530618924 1.0503036626004345 0.42088618187872195 2.8622079392175475 0.44877506266674777 1.1715203007122068 2.0509191280230338e-07 6.68805146442237 -2.0822238807428044 HLEINPDHSIIETLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLEINPDHSIIETLR 15 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 170469500.0 26058600.0 70745500.0 73665400.0 False True 35693168.62718623 67619729.88591641 56267149.70653595 1.0 1.8944725976054937 1.5764122903809454 25.089144645167337 -10.005911921033588 5.019857983515841 0.9999924774120251 1.7354424440005947 0.876980795315994 0.12984757671442373 89543138.49032713 8.182507992831127 7785.901743398713 0.044450279248533044 9.864795325831619e-11 10.005911921033588 0.7354499665885695 HLEINPDHSIIETLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLEINPDHSIIETLR 15 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 66103500.0 34327800.0 20188700.0 11587000.0 False True 28545086.67939008 20079939.465956792 14009788.127765154 1.0 0.7034464351602325 0.49079508095802704 24.766739107407698 -7.71273756528068 0.13992918272916804 1.3465917166484118 2.4294375197990513e-11 0.9999795549151774 0.0009441904668817384 0.13457708011409567 0.017034550815789445 0.061972409293038974 0.08929904079474935 1.9375924552816116e-08 7.71273756528068 -1.3465917166241175 down HLEINPDHSIIETLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLEINPDHSIIETLR 15 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 119205600.0 41824600.0 36257000.0 41124000.0 False True 54142769.18612149 34239266.077535525 33639853.96787316 1.0 0.6323885274473943 0.6213175733999237 25.69026534173332 HLEMNPHFGSHR ddPTM_RPMI8226_Bortezomib_1h_R1 2 HLEMNPHFGSHR 12 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 8010140.0 1328240.0 3276300.0 3405600.0 False True 1741335.5026944587 2787488.8109173737 3053221.1808219496 1.0 1.6007764193655662 1.7533790450476328 20.7317627628024 -11.33740563263822 0.24781666011121667 6.844701247108237e-10 1.8262854363414323 0.9992862528750948 0.0086880768153242 3.6237405850628717 0.1369302309730889 2.0477642362402633 0.07087275197587112 4.598268929472124e-12 11.33740563263822 1.8262854356569622 HLEMNPHFGSHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLEMNPHFGSHR 12 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 3422330.0 800990.0 583240.0 2038100.0 False True 775563.0108897587 816130.7735564191 1504260.4683105992 1.0 1.0523075006118707 1.9395722168142702 19.564884472726227 -6.918994860609373 0.8321496735992152 0.9797050342019437 2.079394313470686 0.9938971163063209 0.03367941135240183 0.09876669271185697 0.10870602114720353 0.02886489537902577 0.08565021774482419 1.2050502007120048e-07 6.918994860609373 1.0996892792687425 HLEMNPHFGSHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLEMNPHFGSHR 12 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 20777000.0 5599600.0 11908000.0 3269400.0 False True 8495002.58559502 9782924.362371331 2623201.6569710732 1.0 1.151609344882395 0.3087935089530447 23.018182955841915 -6.860357915068678 1.1838113397163617 1.0823452867075645 0.2676782285728016 0.9540815789857999 0.07860686698359372 0.14643959792825986 0.3897393438415267 0.05177950799249256 0.12092714058178503 1.3792471172975046e-07 6.860357915068678 -0.8146670581347628 down HLEMNPHFGSHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLEMNPHFGSHR 12 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 6605110.0 967210.0 3034800.0 2603100.0 False True 1324813.674867446 2900712.5012584366 1988301.3925273465 1.0 2.1895248790730264 1.500815873391619 20.337358039002332 -10.122530760762686 4.857477011672305 0.9999538130734011 1.8451703762278127 0.6675491222015502 0.2811642742133962 0.00014068685586458588 2.5414168089307953e-05 0.27225094340824674 0.09074537929567567 7.541699766441473e-11 10.122530760762686 0.8452165631544115 HLEMNPHFGSHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLEMNPHFGSHR 12 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 3186760.0 800990.0 1426500.0 959270.0 False True 666058.6748735625 1418815.1613619213 1159848.921836652 1.0 2.130165426688954 1.7413614829907071 19.345289748160504 -10.114504349710824 4.5603000512474825 0.9999332140138676 1.9357634547081686 0.8853660415326486 0.15872854580341036 110647454.83651479 17.40235923218958 99582.43584516311 0.054337003087266265 7.682377612945138e-11 10.114504349710824 0.935830240694301 HLEMNPHFGSHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLEMNPHFGSHR 12 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 15128400.0 5599600.0 4066200.0 5462600.0 False True 7248792.584617815 3839912.3955229316 4468462.851009243 1.0 0.5297313105180242 0.6164423659316 22.789309277934365 -10.35446121376591 6.861298728859585 1.000015889286574 0.5730868382248403 0.9699878287602631 0.035399640136909584 8.604548273491153e-06 8.095801029629564e-07 0.03427682736035789 0.011425184725998867 4.4211860010767775e-11 10.35446121376591 -0.42692905106173373 HLFLLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLFLLLK 7 0 O75691 O75691 UTP20 Small subunit processome component 20 homolog 0 6638820.0 700120.0 1701600.0 4237100.0 False True 958973.2840315921 1626417.6855612763 3236384.2458136897 1.0 1.6959989528839639 3.3748429697725255 19.871131098301685 -6.956224247264383 0.48573823822688955 0.9618003653885596 4.1797190523494425 0.999603496910458 0.019849018598046563 0.08107861032744448 0.026333158733731234 0.02395356018168126 0.13847036299065835 1.1060525280446677e-07 6.956224247264383 3.217918686960883 HLFLLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLFLLLK 7 0 O75691 O75691 UTP20 Small subunit processome component 20 homolog 0 10293500.0 3375200.0 3247500.0 3670800.0 False True 4369262.935138591 3066773.770218072 3002752.065588681 1.0 0.7018972801005842 0.687244533040087 22.058958496760322 HLFLTSKPMVYLVNLSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLFLTSKPMVYLVNLSEK 18 1 J3KQ32;Q9NTK5;Q9NTK5-2;Q9NTK5-3;C9JCJ9 J3KQ32 OLA1 Obg-like ATPase 1 0 11449200.0 3571100.0 3853700.0 4024400.0 False True 3457737.385221313 5392502.50678001 2970288.9105878896 1.0 1.5595465780102504 0.8590267506384889 21.721396869933578 -6.693976167095879 1.8521522902089238 1.3494926363955078 0.8613200896811878 0.3890536451602762 0.23646300163071093 0.40823624835771116 2.7181585496426575 0.10201457107410712 0.2643425262529645 2.0231301995341492e-07 6.693976167095879 -0.48817254671432 HLFLTSKPMVYLVNLSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLFLTSKPMVYLVNLSEK 18 1 J3KQ32;Q9NTK5;Q9NTK5-2;Q9NTK5-3;C9JCJ9 J3KQ32 OLA1 Obg-like ATPase 1 0 30389400.0 8912700.0 13627000.0 7849700.0 False True 13521217.505649105 11195155.38176303 6298203.354354265 1.0 0.8279694766455568 0.4658014969231065 23.688721727834526 -6.959029645666461 0.4489041230037336 1.0118108680545976 0.26762898633093324 0.9997324879367842 0.0036414949905316358 0.08004964705152519 0.022426319863180312 0.004832918909942898 0.029962194398794342 1.0989308220193862e-07 6.959029645666461 -0.7441818817236644 down HLFLTSKPMVYLVNLSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLFLTSKPMVYLVNLSEK 18 1 J3KQ32;Q9NTK5;Q9NTK5-2;Q9NTK5-3;C9JCJ9 J3KQ32 OLA1 Obg-like ATPase 1 0 11485400.0 0.0 4192500.0 7292900.0 False True 0.0 4007261.487256492 5570467.2219902 0.0 HLFLTSKPMVYLVNLSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLFLTSKPMVYLVNLSEK 18 1 J3KQ32;Q9NTK5;Q9NTK5-2;Q9NTK5-3;C9JCJ9 J3KQ32 OLA1 Obg-like ATPase 1 0 9575100.0 3571100.0 2592100.0 3411900.0 False True 2969527.876553991 2578135.8428084347 4125312.5151568074 1.0 0.8681972185424474 1.3892149481836333 21.501802145367854 -6.839656186287214 1.2840038598945982 0.9298811338381516 1.4062341094518966 0.923861106736201 0.06103319330661107 0.169199198657526 0.5420199681503706 0.03727480826419466 0.08586554546383496 1.446584521138533e-07 6.839656186287214 0.476352975613745 HLGVCISVANNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLGVCISVANNR 12 0 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 232128200.0 53126200.0 88293000.0 90709000.0 False True 69648962.67485256 75120028.5634185 81323302.82216881 1.0 1.078552008220236 1.16761685600138 26.053598530247104 -6.969491204904566 0.2700674651227129 0.977877212957696 1.2709694276896453 0.9999781286089865 0.0003201800149439149 0.07646819662613961 0.009619669906731911 0.0017451516120444133 0.008282750835634359 1.0727753728784206e-07 6.969491204904566 0.29309221473194924 HLGVCISVANNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLGVCISVANNR 12 0 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 128272900.0 95922000.0 16517300.0 15833600.0 False True 92877008.61504811 23112744.026581604 11686305.162181789 1.0 0.24885323473733018 0.12582559813719443 26.468818170806337 -13.999999999999998 0.25459535822528556 6.347285896837283 0.07847637030373483 0.9995515145365504 0.008182345688843344 14.184912245105977 0.1596622437495874 38.89791593507559 0.05536204278996644 1.0000000000000041e-14 13.999999999999998 -6.268809526533548 HLGVCISVANNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLGVCISVANNR 12 0 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 1648469000.0 451749000.0 583810000.0 612910000.0 False True 685336260.2757282 479624544.1716505 491768069.852004 1.0 0.6998382720603246 0.7175573486424798 29.352236779289495 -10.091253528235471 4.813780256079573 1.0000122980962765 0.7086978103484456 0.9972327223595939 0.007233782733459643 9.547980375678102e-07 1.8025171421102633e-07 0.007004375666134613 0.0023346933366145163 8.10487781000833e-11 10.091253528235471 -0.29131448774783086 HLGVCISVANNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLGVCISVANNR 12 0 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 365620200.0 53126200.0 127258000.0 185236000.0 False True 72768391.82157215 121635320.7740695 141487071.85517085 1.0 1.6715405924088427 1.9443479279038716 26.116808591769995 -10.593309031154966 0.18882529647798357 1.7151282560810978e-17 2.1965205534684307 0.9994484773404547 0.009319087810024449 2.4018517680803306 0.09884667523465145 1.2893512809709995 0.18217465788411485 2.5508855217453145e-11 10.593309031154966 2.1965205534684307 HLGVCISVANNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLGVCISVANNR 12 0 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 154985800.0 95922000.0 10880700.0 48183100.0 False True 79763393.06510921 10822083.509450149 58257963.43651685 1.0 0.1356773213072356 0.7303847190773602 26.249223446240613 -10.261987819278087 7.288112074888735 1.0000023705209713 0.4330310202960301 0.5478907930562626 0.24278827846586598 9.351747091515878e-06 9.468654542454437e-07 0.23507972023926166 0.07835957992938901 5.470313053471789e-11 10.261987819278087 -0.5669713502249412 HLGVCISVANNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLGVCISVANNR 12 0 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 1488925000.0 451749000.0 571260000.0 465916000.0 False True 584797985.8040782 539468878.822102 381124068.7018675 1.0 0.9224875801860873 0.6517191884268109 29.123363101381944 -6.947989307675501 0.580506703328923 1.0032305064537235 0.557572157469732 0.9990338317592581 0.004640827089716221 0.08430351171096756 0.03938362749321775 0.0048597113524947765 0.022621933708635217 1.127225208103854e-07 6.947989307675501 -0.4456583489839915 HLGVILPAVMLALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLGVILPAVMLALK 14 0 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 35006000.0 9977000.0 11013000.0 14016000.0 False True 15135838.416401448 9047644.105038268 11245731.456568955 1.0 0.5977629950934261 0.7429870184384957 23.851465256501704 -10.145439200512259 4.6683907328882235 1.000033775080331 0.6703750067621705 0.8729212345502707 0.05928745927788777 82909724.49260575 1.149756890274386 30101.365991364783 0.020295674262845165 7.154195429350905e-11 10.145439200512259 -0.32965876831816043 HLGVILPAVMLALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLGVILPAVMLALK 14 0 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 20093000.0 9977000.0 4936900.0 5179100.0 False True 12915423.176071858 4662157.17511612 4236556.94205359 1.0 0.36097595189552933 0.3280230840521411 23.622591578594154 -13.639750127843946 0.4256708871613273 9.9444177102774 0.32715631611210194 0.9998658935202656 0.0035818077161793404 22.418587085562034 0.21799539478454397 184.82110932644858 0.007885057840115044 2.2921860870737704e-14 13.639750127843946 -9.617261394165297 HLHYWFVESQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLHYWFVESQK 11 0 X6R5C5;X6R8A1;P10619-2;P10619;U3KQ41;U3KQU6 X6R5C5 CTSA Carboxypeptidase;Lysosomal protective protein;Lysosomal protective protein 32 kDa chain;Lysosomal protective protein 20 kDa chain 0 8181600.0 3329600.0 1972700.0 2879300.0 False True 4560643.099056712 1885539.591153462 2199268.6410449 1.0 0.4134372171204215 0.48222774579746863 22.120805843363822 -10.373296419910837 5.855070095677504 1.0001182163278923 0.44783248146024346 0.988493305117314 0.0280836157325127 4.3346701008918165e-05 4.63970103764705e-06 0.027197595719722256 0.009063948002775442 4.2335391479444366e-11 10.373296419910837 -0.5522857348676489 HLIFVLNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLIFVLNK 8 0 Q13823;H0YG10 Q13823 GNL2 Nucleolar GTP-binding protein 2 0 16272400.0 5076000.0 4475500.0 6720900.0 False True 6654685.156053931 3807772.84536236 6025485.739425144 1.0 0.5721942895973576 0.9054501600190072 22.665938980834067 -9.823955554655512 6.2275319167716505 1.0000000123903021 0.7388222248080519 0.45023123267860765 0.1360511393871519 2.3378005315993613e-08 4.5704611257085215e-09 0.1317309561398404 0.043910316423179996 1.4998383198837995e-10 9.823955554655512 -0.2611777875822502 HLIFVLNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLIFVLNK 8 0 Q13823;H0YG10 Q13823 GNL2 Nucleolar GTP-binding protein 2 0 8260700.0 3807300.0 1600500.0 2852900.0 False True 3686439.345510656 2239587.9964972367 2105639.9048345545 1.0 0.6075206416252599 0.5711852840868796 21.813796589239548 -13.999999999999998 0.336688746760578 5.448845033399903 0.5652435057548478 0.999728550941532 0.003198727538674642 19.404003806109962 0.1859264707607401 61.338216414621485 0.0113606784852894 1.0000000000000041e-14 13.999999999999998 -4.883601527645055 HLIFVLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLIFVLNK 8 0 Q13823;H0YG10 Q13823 GNL2 Nucleolar GTP-binding protein 2 0 16281400.0 5076000.0 3675900.0 7529500.0 False True 6952734.373742166 3513486.5834242436 5751187.174920149 1.0 0.5053388198883804 0.8271835030315837 22.72914904235696 -10.144956108395721 5.310253003681806 1.0000096140716963 0.6662611614598256 0.589103721358267 0.13139254168865117 1.4955609668824158e-05 2.408422076395529e-06 0.12722394416221952 0.0424067604812541 7.162157902980515e-11 10.144956108395721 -0.3337484526118707 HLIFVLNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLIFVLNK 8 0 Q13823;H0YG10 Q13823 GNL2 Nucleolar GTP-binding protein 2 0 5247700.0 3807300.0 1440400.0 0.0 False True 3165938.641988185 1432640.279302987 0.0 1.0 0.4525167545266449 0.0 21.594201864673824 -8.084591431475229 0.5650749709896481 1.0191831361628017 1.079151409417158e-17 0.9902688657002751 0.04033275746667863 0.1148974820871957 0.1683382942087632 0.04872699062666133 0.074993312943486 8.230165500340355e-09 8.084591431475229 -1.0191831361628017 HLIILPFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLIILPFK 8 0 A0A087WXK4;Q7Z3F1 A0A087WXK4 GPR155 Integral membrane protein GPR155 0 16274600.0 4198900.0 3344300.0 8731400.0 False True 5504798.562205442 2845343.475979296 7827958.48550293 1.0 0.5168842136231299 1.422024511350464 22.39225834135643 -6.76175435610218 1.6063131597824212 0.7199861650695714 1.4255690654323152 0.6979182127787877 0.20325068926883427 0.2799807799257863 1.424272712106487 0.09982569233741674 0.2394403050170316 1.7307950477405207e-07 6.76175435610218 0.7055829003627438 HLIILPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLIILPFK 8 0 A0A087WXK4;Q7Z3F1 A0A087WXK4 GPR155 Integral membrane protein GPR155 0 15683600.0 5248900.0 2723500.0 7711200.0 False True 5082276.542602601 3811007.752864871 5691405.388958684 1.0 0.7498623345106834 1.1198535422561149 22.277043448412147 -6.724614509916876 1.7427544061542206 0.8485720672266015 1.1194298504801241 0.5341523392171639 0.10520398637142919 0.346441514530099 2.0587251986294866 0.04788747305988191 0.11956598220001012 1.8853218033601432e-07 6.724614509916876 0.2708577832535226 HLIILPFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLIILPFK 8 0 A0A087WXK4;Q7Z3F1 A0A087WXK4 GPR155 Integral membrane protein GPR155 0 13913600.0 4198900.0 2981800.0 6732900.0 False True 5751346.8010059 2850054.2165060034 5142727.688428163 1.0 0.49554553309279387 0.8941779841077762 22.455468402879323 -9.89404640778177 6.625596031011127 1.0000000143514218 0.6948617586002767 0.43859461103302755 0.1627410166503213 3.4410966661777874e-08 6.024580086267918e-09 0.15757331885194245 0.05252443726929132 1.2763024185708268e-10 9.89404640778177 -0.30513825575114517 HLIILPFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLIILPFK 8 0 A0A087WXK4;Q7Z3F1 A0A087WXK4 GPR155 Integral membrane protein GPR155 0 9211800.0 5248900.0 1209500.0 2753400.0 False True 4364692.915696631 1202984.183433048 3329123.2097167997 1.0 0.2756171411525396 0.7627393894641158 22.057448723846424 -9.82388254468833 5.911365932555643 1.0000000536442741 0.5191782653091627 0.5650406303012693 0.1988668251233598 1.40777113838963e-07 2.8151940238889073e-08 0.1925519955371853 0.0641839918175184 1.5000904813916513e-10 9.82388254468833 -0.48082178833511147 HLIPAANTGESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLIPAANTGESK 12 0 P62258;P62258-2 P62258 YWHAE 14-3-3 protein epsilon 0 55871380.0 8133600.0 30602700.0 17135080.0 False True 10663228.365894446 26036896.448390305 15362106.292893652 1.0 2.4417461161825447 1.440661848903867 23.346140954310748 -10.362830593587324 5.887359412302304 0.9998331068721782 1.941203982543207 0.540988791384118 0.4086909407267938 0.000895428094931563 9.690896646001435e-05 0.395781417055921 0.13190443393172563 4.336800121229613e-11 10.362830593587324 0.9413708756710288 HLIPAANTGESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLIPAANTGESK 12 0 P62258;P62258-2 P62258 YWHAE 14-3-3 protein epsilon 0 50093950.0 10499000.0 9743700.0 29851250.0 False True 10165714.991862057 13634410.22272425 22032312.10669585 1.0 1.3412150777037308 2.167315542913936 23.277208352973886 -6.956145843865384 0.48672459619852404 0.9813730829670354 2.561993792676921 0.9995994613519302 0.009807945187582361 0.0811077910055905 0.026445668743148968 0.011811254526442513 0.0681355662974962 1.1062522222830285e-07 6.956145843865384 1.5806207097098857 up HLIPAANTGESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLIPAANTGESK 12 0 P62258;P62258-2 P62258 YWHAE 14-3-3 protein epsilon 0 50518680.0 8133600.0 20970370.0 21414710.0 False True 11140811.72227526 20043829.713659853 16356996.547796573 1.0 1.7991354861139643 1.468205096320937 23.40935101583364 -10.262594488711692 5.006971258870699 0.9998712654634918 1.6336702912178003 0.8301828231183895 0.13510176589675704 0.00019418685313540556 2.859910906405463e-05 0.130838003758412 0.04360390744660572 5.462676864205309e-11 10.262594488711692 0.6337990257543085 HLIPAANTGESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLIPAANTGESK 12 0 P62258;P62258-2 P62258 YWHAE 14-3-3 protein epsilon 0 29039300.0 10499000.0 11565000.0 6975300.0 False True 8730383.684562283 11502697.049527247 8433802.979856765 1.0 1.317547712120279 0.9660289037204683 23.057613628408163 -6.668771136035871 1.9418269227705827 1.2029031263740861 0.9674597629274742 0.2735984389057162 0.13492560592597352 0.4639287258627526 3.37139121288716 0.05596327821895425 0.14975451327575995 2.1440201565346923e-07 6.668771136035871 -0.235443363446612 HLIPAANTGESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLIPAANTGESK 12 0 P62258;P62258-2 P62258 YWHAE 14-3-3 protein epsilon 0 26036360.0 1524500.0 21634860.0 2877000.0 False True 1973495.3023876445 20430861.02242961 2353415.5205128663 1.0 10.352627137095903 1.1925113364422875 20.91232165443808 -6.641337317390489 2.039631688070872 7.10987438117837 1.2306261139882058 0.15978232729789565 4.000376405932046 0.5299690149769622 4.215343307563112 1.5962900755612102 4.4297656567351975 2.283824263458755e-07 6.641337317390489 -5.879248267190165 HLIPAANTGESK(ub)VFYYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLIPAANTGESKVFYYK 17 1 P62258;P62258-2 P62258 YWHAE 14-3-3 protein epsilon 1 17747300.0 6533300.0 0.0 11214000.0 True False 8457485.640596397 0.0 9173167.065356709 1.0 0.0 1.0846210629462971 23.01179739188935 -10.429467410904184 4.3770847087928475 1.0014564696785737 0.5423105314718599 0.19186952191585072 0.4427946947532778 0.006312121736638016 0.0008227543544191367 0.43000445333829285 0.14291137321342876 3.719911340192018e-11 10.429467410904184 -0.4591459382067138 HLIVLINK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLIVLINK 8 0 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 586526300.0 177226300.0 241300000.0 168000000.0 False True 268865254.07804805 198238129.7144951 134794726.36298415 1.0 0.7373140512122447 0.5013467687567208 28.002308084379596 -6.972397419413473 0.19249326360691507 1.1548076046571103 0.07739012514741353 0.9999955425812913 0.0004299651824185339 0.07553214915824641 0.006159082642777549 0.008156127984594603 0.025547931767601218 1.0656205340783059e-07 6.972397419413473 -1.0774174795096967 HLIVLINK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLIVLINK 8 0 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 62049080.0 962180.0 59341600.0 1745300.0 False True 1317923.9479368066 56719691.89557058 1333096.0855817953 1.0 43.03715095576232 1.0115121495961437 20.32983568997355 -6.243421684950177 22.512559628966432 9.999999999999998 1.0114807021107783 0.004504736667681808 19.769111793180713 799.3197323360472 2734927.016031025 8.371272968333619 51.826552808811805 5.709240199433989e-07 6.243421684950177 -8.98851929788922 HLIVLINK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLIVLINK 8 0 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 545973300.0 177226300.0 246377000.0 122370000.0 False True 229422939.00265226 232665903.36721087 100099915.62223141 1.0 1.0141353100028114 0.4363117134554457 27.773434406472045 -6.9012927294050215 0.9530543500881243 1.0231790948528539 0.3740405161975509 0.9871986910455722 0.03044887378613871 0.11046013892209788 0.17209971106547367 0.023902098147112662 0.0626027265603209 1.2551836415939063e-07 6.9012927294050215 -0.649138578655303 down HLK(ub)GEDDKPLPTSKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLKGEDDKPLPTSKPR 16 3 Q03989;Q03989-5;A0A669KBH0 Q03989 ARID5A AT-rich interactive domain-containing protein 5A 1 6654140.0 673840.0 1394100.0 4586200.0 True False 652449.3180413675 1950771.4001354594 3384936.6369491545 1.0 2.989920207122929 5.188045329115568 19.315506312594096 -6.969843737831594 0.26189280969139306 0.39696280377850207 7.846379334929678 0.9999811378050035 0.007428661189927285 0.07635347432610291 0.009211479223455821 0.04533151880251699 0.20681350159302309 1.0719049146878325e-07 6.969843737831594 7.449416531151177 HLK(ub)GEDDKPLPTSKPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLKGEDDKPLPTSKPR 16 3 Q03989;Q03989-5;A0A669KBH0 Q03989 ARID5A AT-rich interactive domain-containing protein 5A 1 3516640.0 673840.0 1412600.0 1430200.0 True False 560327.8161734869 1404990.0434208524 1729248.207502349 1.0 2.5074429697522707 3.0861366464215383 19.095911588028372 -9.613728548194935 0.2690194049038264 5.1892658740631346e-24 3.3796660018550018 0.9989522729626292 0.02846319307551802 1.0081591662321803 0.11107460062109177 1.0804769783348132 0.2327088367168201 2.4337247112085144e-10 9.613728548194935 3.3796660018550018 HLK(ub)SLDLTDNALGDGGVAALCEGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLKSLDLTDNALGDGGVAALCEGLK 25 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 34063900.0 14566000.0 9896100.0 9601800.0 True False 19096167.057344634 8419640.454695672 8608297.842969295 1.0 0.4409073522142952 0.45078668494672763 24.186779756803165 -10.537840441727974 6.291048322864379 1.0006857432796623 0.44584701858051146 0.9997616832771303 0.004033220698939239 3.883581621576571e-05 2.8530002976589346e-06 0.003909594104324832 0.0013017163832142195 2.8984082571567128e-11 10.537840441727974 -0.5548387246991509 HLK(ub)SLDLTDNALGDGGVAALCEGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLKSLDLTDNALGDGGVAALCEGLK 25 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 149346100.0 64968700.0 45446800.0 38930600.0 True False 62906304.18056842 63593944.24193105 28733507.9670343 1.0 1.0109311788432016 0.45676674764673264 25.906701268824808 -6.902401260188436 0.9459599439483 1.0215468016280835 0.39567535373986573 0.9877236306925257 0.028663378440544517 0.10965936929777147 0.16761783684580714 0.0226189633640576 0.05959253905929221 1.2519838877490964e-07 6.902401260188436 -0.6258714478882178 down HLK(ub)SLDLTDNALGDGGVAALCEGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLKSLDLTDNALGDGGVAALCEGLK 25 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 329899000.0 73688000.0 77993000.0 178218000.0 True False 111790083.3144019 64074539.787909664 142993134.18427578 1.0 0.5731683695744679 1.2791218142499943 26.736216974223847 -6.743022642970276 1.6756741720193864 0.7469273237602311 1.2798102018685489 0.6183985092560975 0.1793293622206537 0.3123832412030148 1.7233805657077401 0.08462479663469497 0.20697308986423302 1.807079907168604e-07 6.743022642970276 0.5328828781083178 HLK(ub)SLDLTDNALGDGGVAALCEGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLKSLDLTDNALGDGGVAALCEGLK 25 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 262492000.0 14566000.0 10672000.0 237254000.0 True False 19951443.831349127 10200475.752415348 181219491.59950912 1.0 0.5112650411990552 9.083026428130689 24.249989818326057 -6.893389741804758 1.0021334180196217 0.5761534285509946 9.871110550348334 0.9829800920331773 0.5127925507904403 0.11643520395538644 0.2061358490262032 0.38805683999696183 0.9799981297773042 1.278233684907969e-07 6.893389741804758 9.294957121797339 up HLK(ub)SLDLTDNALGDGGVAALCEGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLKSLDLTDNALGDGGVAALCEGLK 25 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 149771900.0 64968700.0 17286200.0 67517000.0 True False 54024352.65141643 17193075.809557956 81634492.53666349 1.0 0.3182467714235014 1.5110684076752776 25.687106544259084 -6.751709215238151 1.643793258620646 0.5999450554767601 1.5137145692632445 0.6562025339017763 0.2865023999944693 0.2970626348242163 1.5798291087455032 0.13766272515042258 0.3335743761153659 1.7712945434195848e-07 6.751709215238151 0.9137695137864844 HLK(ub)SLDLTDNALGDGGVAALCEGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLKSLDLTDNALGDGGVAALCEGLK 25 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 209227000.0 73688000.0 17681000.0 117858000.0 True False 95390568.60763569 16697036.807151869 96409053.32520182 1.0 0.17503865477341674 1.010676995980131 26.507343296316296 -9.16748371936285 12.492320607847109 0.9999631900397891 0.5928578253767471 0.24041879111188236 0.34114792490566737 0.0 0.0 0.33031505763910807 0.110105019213036 6.80011536493625e-10 9.16748371936285 -0.4071053646630419 HLK(ub)SLDLTDNALGDGGVAALCEGLK(ub)QK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLKSLDLTDNALGDGGVAALCEGLKQK 27 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 2 39064900.0 3979000.0 4702900.0 30383000.0 True False 3852688.8229944785 6580792.495299504 22424780.829537783 1.0 1.7081038198627794 5.8205533485334175 21.877434235297727 -6.9365280101796705 0.6911065069927089 0.9499157470779479 6.824760486066696 0.9976728956715036 0.10252371959873617 0.08938682107880733 0.06209339892742506 0.09734625553016754 0.3596964260805205 1.1573693841950461e-07 6.9365280101796705 5.874844738988748 HLK(ub)SLDLTDNALGDGGVAALCEGLK(ub)QK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLKSLDLTDNALGDGGVAALCEGLKQK 27 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 2 89266300.0 18893800.0 21989500.0 48383000.0 True False 28663275.921800718 18065301.920252334 38820078.84297774 1.0 0.6302594989329962 1.3543489916814413 24.77270016864935 -6.767892660395626 1.5824334711084802 0.7873553998805886 1.3581088953525353 0.7224550110079215 0.15574568303481345 0.269857223596747 1.333273140159666 0.07759184989431274 0.18506671333067984 1.7065041140060007e-07 6.767892660395626 0.5707534954719468 HLK(ub)SLDLTDNALGDGGVAALCEGLK(ub)QK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLKSLDLTDNALGDGGVAALCEGLKQK 27 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 2 35874700.0 3979000.0 4446700.0 27449000.0 True False 3308714.7995878886 4422744.744499159 33188458.990163624 1.0 1.3366956695844643 10.030619440000496 21.657839510732003 -6.915074073071386 0.8604682286331338 0.772063800890486 11.28519115655642 0.9926995934134002 0.3571472148580939 0.10115737466935322 0.12127510091385653 0.29994554008412344 0.8601997181694521 1.2159785861981836e-07 6.915074073071386 10.513127355665935 up HLK(ub)SLDLTDNALGDGGVAALCEGLK(ub)QK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLKSLDLTDNALGDGGVAALCEGLKQK 27 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 2 62521800.0 18893800.0 17090000.0 26538000.0 True False 24458396.552477352 16138926.476682609 21708356.30287466 1.0 0.6598521878593028 0.8875625291419953 24.5438264907418 -9.929866638069438 5.105184510861432 1.0000007788290963 0.773707358496919 0.5683669303010068 0.09296235756258192 127239609.81266151 3.3468793901758973 1164.8391248688533 0.0318234876454533 1.1752583945830752e-10 9.929866638069438 -0.22629342033217736 HLLEGAK(ub)SESAEELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLLEGAKSESAEELK 15 1 J3KQL8;Q9BQE5 J3KQL8 APOL2 Apolipoprotein L2 1 18177000.0 7891000.0 7422600.0 2863400.0 True False 10345177.416552713 6315177.01306819 2567122.8356723 1.0 0.6104464678356937 0.24814681588396897 23.302455051389735 -7.626316484388083 0.3115678219222589 1.0878896155597717 4.3700216910419854e-10 0.9995050999008054 0.006829849315133428 0.12569936834575046 0.04008271029903987 0.029101650487205272 0.0733453109426831 2.3641962035978034e-08 7.626316484388083 -1.0878896151227695 down HLLEGAK(ub)SESAEELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLLEGAKSESAEELK 15 1 J3KQL8;Q9BQE5 J3KQL8 APOL2 Apolipoprotein L2 1 25852600.0 8845900.0 8106100.0 8900600.0 True False 8565091.74650086 11342908.00275307 6569265.847723526 1.0 1.3243183305522728 0.7669813753492251 23.030037269400278 -6.748954922693599 1.6536203574260637 1.1909438155221823 0.7659563629331644 0.6444675168951103 0.13627481810483114 0.30188794150172266 1.6238319816969757 0.0651079693587651 0.15824409340249448 1.7825637778660987e-07 6.748954922693599 -0.42498745258901793 HLLEGAK(ub)SESAEELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLLEGAKSESAEELK 15 1 J3KQL8;Q9BQE5 J3KQL8 APOL2 Apolipoprotein L2 1 53867000.0 24089000.0 11788000.0 17990000.0 True False 36544774.14179552 9684339.299935626 14434268.614702888 1.0 0.26499929271309525 0.39497490280545217 25.12316178150424 -10.468731203061147 6.005733404239796 1.000431940976164 0.3299870977909332 0.9725507219363426 0.053062320622202744 0.00030707382431737515 2.716368469305748e-05 0.05140864595378358 0.01712579034007575 3.3983554118532945e-11 10.468731203061147 -0.6704448431852308 HLLEGAK(ub)SESAEELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLLEGAKSESAEELK 15 1 J3KQL8;Q9BQE5 J3KQL8 APOL2 Apolipoprotein L2 1 18083500.0 7891000.0 6247800.0 3944700.0 True False 10808515.946256783 5971751.537288287 3013043.1036466616 1.0 0.5525043000335703 0.27876566206021486 23.365665112912627 -8.599000085290031 0.21241833412550595 1.3083425779545108 1.8407558966929614e-12 0.9996075586443672 0.00588910019855008 0.20589502523262632 0.05756940778680875 0.16424150816530106 0.12449795584276722 2.5176764333184893e-09 8.599000085290031 -1.30834257795267 down HLLEGAK(ub)SESAEELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLLEGAKSESAEELK 15 1 J3KQL8;Q9BQE5 J3KQL8 APOL2 Apolipoprotein L2 1 25627800.0 8845900.0 12772000.0 4009900.0 True False 7355757.789815171 12703194.700956505 4848351.550317206 1.0 1.7269729460838732 0.6591233274470055 22.810442544834554 -6.723417133334665 1.747202681081195 1.4406620120900606 0.6604795514076202 0.5285268743914777 0.30579123619149845 0.3487119229544153 2.0822239790150117 0.13887516270711317 0.3472111695673174 1.8905269235816874e-07 6.723417133334665 -0.7801824606824405 HLLEGAK(ub)SESAEELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLLEGAKSESAEELK 15 1 J3KQL8;Q9BQE5 J3KQL8 APOL2 Apolipoprotein L2 1 50669000.0 24089000.0 12414000.0 14166000.0 True False 31183685.365179367 11723149.987216968 11587933.35543456 1.0 0.3759385669118951 0.37160243312273766 24.89428810359669 HLLIGLPSGAILSLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLLIGLPSGAILSLPK 16 0 Q8N766-3;Q8N766-2;Q8N766;Q8N766-4;H7C4E3 Q8N766-3 EMC1 ER membrane protein complex subunit 1 0 5520090.0 1950360.0 2701230.0 868500.0 False True 2556940.8473131065 2298217.0133120716 778635.9512402707 1.0 0.8988150882438645 0.3045185625074118 21.285987354747242 -6.936287730157589 0.6932358895667405 1.0072884704113028 0.160363647797963 0.9976361596954929 0.014916280744172672 0.08950167999562826 0.06263156697953286 0.014139923983211528 0.052041151910493855 1.1580098935648155e-07 6.936287730157589 -0.8469248226133398 down HLLIGLPSGAILSLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLLIGLPSGAILSLPK 16 0 Q8N766-3;Q8N766-2;Q8N766;Q8N766-4;H7C4E3 Q8N766-3 EMC1 ER membrane protein complex subunit 1 0 10879100.0 4436300.0 3664700.0 2778100.0 False True 4295472.084807847 5128033.821158029 2050432.2687864557 1.0 1.193823104867745 0.4773473621300881 22.034385265759802 -6.834669006003189 1.306968438657275 1.103279088137414 0.45616909283625234 0.9148841858010726 0.0882807676307237 0.17512006013881928 0.5833633481627135 0.05300762903473288 0.12199646516395414 1.4632919856313044e-07 6.834669006003189 -0.6471099953011616 down HLLIGLPSGAILSLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLLIGLPSGAILSLPK 16 0 Q8N766-3;Q8N766-2;Q8N766;Q8N766-4;H7C4E3 Q8N766-3 EMC1 ER membrane protein complex subunit 1 0 35301100.0 15577300.0 10306000.0 9417800.0 False True 23631902.95317334 8466813.778854465 7556367.702031627 1.0 0.3582789670231582 0.319752823841761 24.49423247086429 -13.787187328929456 0.4019133302846869 9.999896941956827 0.3175595086161395 0.9998367886366024 0.00398576854475721 22.61705095776546 0.20884188804285517 176.46939635377572 0.00980971273015512 1.6323476978567582e-14 13.787187328929456 -9.682337433340688 HLLIGLPSGAILSLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLLIGLPSGAILSLPK 16 0 Q8N766-3;Q8N766-2;Q8N766;Q8N766-4;H7C4E3 Q8N766-3 EMC1 ER membrane protein complex subunit 1 0 11056560.0 1950360.0 4926700.0 4179500.0 False True 2671460.798497193 4709022.103581772 3192388.179504448 1.0 1.762714282100187 1.1949972020178241 21.349197416270133 -10.407311818337659 5.350607869687056 0.9996771783521724 1.478855742059013 0.48681167326324304 0.23176952741078646 0.000893119375649388 9.893094685727082e-05 0.22455757593118156 0.07480329331835789 3.914607119893353e-11 10.407311818337659 0.47917856370684053 HLLIGLPSGAILSLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLLIGLPSGAILSLPK 16 0 Q8N766-3;Q8N766-2;Q8N766;Q8N766-4;H7C4E3 Q8N766-3 EMC1 ER membrane protein complex subunit 1 0 7957820.0 4436300.0 986620.0 2534900.0 False True 3688980.0114128585 981304.8822312643 3064935.869946657 1.0 0.26600981279251495 0.8308355861144404 21.81479054119408 -10.187637620638139 7.385062355730668 1.0000004522569752 0.5484226994545458 0.46012003399711887 0.23058915636860547 1.7170881617400796e-06 1.8875799517951787e-07 0.22326721349948378 0.0744223302026356 6.491758860277601e-11 10.187637620638139 -0.4515777528024294 HLLIGLPSGAILSLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLLIGLPSGAILSLPK 16 0 Q8N766-3;Q8N766-2;Q8N766;Q8N766-4;H7C4E3 Q8N766-3 EMC1 ER membrane protein complex subunit 1 0 32545200.0 15577300.0 6041300.0 10926600.0 False True 20165121.92448875 5705096.344270488 8938070.916383686 1.0 0.28291901063797464 0.4432440800434334 24.26535879295674 -10.314884358314442 8.52629845734918 1.0000009174520679 0.36308154535310144 0.9546337123944 0.06545243550327873 1.1415177426624922e-06 9.170702950854696e-08 0.06337413974923943 0.02112468272274281 4.8430130766073936e-11 10.314884358314442 -0.6369193720989664 HLLIGVSSDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLLIGVSSDR 10 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 97314000.0 38914000.0 30994000.0 27406000.0 False True 51016630.843711995 26369816.01366574 24570290.0169152 1.0 0.5168866618113008 0.4816133407983288 25.60446429020866 -13.999999999999998 0.3714136271488023 7.7894849150278676 0.4780373164741271 0.9997933106917548 0.003400005990400208 22.9855971992947 0.19793990980222462 124.3296918210314 0.00981466302177375 1.0000000000000041e-14 13.999999999999998 -7.31144759855374 HLLIGVSSDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLLIGVSSDR 10 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 76222000.0 32060000.0 11855000.0 32307000.0 False True 31042272.84875676 16588763.323008314 23844827.510775022 1.0 0.5343926781338336 0.768140516867147 24.887730856645902 -10.106014818887918 5.378927351887684 1.000005417665499 0.6512665975003 0.7479694276194737 0.09542715556316679 6.1999005493730205e-06 1.03042259493209e-06 0.09239838099269364 0.0307989820225774 7.834029112315407e-11 10.106014818887918 -0.3487388201651991 HLLIGVSSDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLLIGVSSDR 10 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 119645000.0 32126000.0 47920000.0 39599000.0 False True 48737490.72519916 39368301.59933113 31772240.293141697 1.0 0.8077621767871649 0.6519055417170713 25.53852863928794 -6.973512322277669 0.15248809481414166 1.1749920622941863 0.28056767715744596 0.9999984336447911 0.00017808515916038913 0.07517854800553725 0.004672149588442729 0.007760112252669346 0.01924894919899024 1.0628884254158481e-07 6.973512322277669 -0.8944243851367404 HLLIGVSSDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLLIGVSSDR 10 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 102507000.0 38914000.0 25809000.0 37784000.0 False True 53301557.411308505 24668673.041050192 28860197.385906473 1.0 0.4628133630447441 0.5414512968768052 25.667674351731552 -10.688660809251418 6.75799556523542 1.0039181860454511 0.5021323299609005 0.9816326455185846 0.03210380205254931 0.0019030595535919333 8.767341234598541e-05 0.03121283413693142 0.01036145755828859 2.0480435661445315e-11 10.688660809251418 -0.5017858560845506 HLLIGVSSDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLLIGVSSDR 10 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 59744100.0 32060000.0 18288000.0 9396100.0 False True 26659310.49881575 18189478.914116208 11360781.067342203 1.0 0.6822936742840447 0.42614684531495545 24.66813613208018 -7.407902217145525 0.18701781645216187 1.2127322653186927 1.989693076674274e-14 0.9999738660579046 0.0011999245673848344 0.12133401390700362 0.014422824683185466 0.027191335299749757 0.057386663728059104 3.909289048340895e-08 7.407902217145525 -1.2127322653186727 down HLLIGVSSDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLLIGVSSDR 10 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 123700000.0 32126000.0 48560000.0 43014000.0 False True 41587740.29813409 45857593.31232929 35185893.36091084 1.0 1.102670955035919 0.8460640830367386 25.30965496138039 -6.798099198188029 1.4634989563909542 1.0567843985602776 0.8426789211125854 0.8266102084294514 0.04391109864924621 0.22347067408018756 0.9451055864739111 0.023605729680414328 0.054966963457006725 1.5918450885744157e-07 6.798099198188029 -0.21410547744769226 HLLLYQALGWQPPHFAHLPLLLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLLLYQALGWQPPHFAHLPLLLNR 24 0 H3BTB7;Q5JPH6;Q5JPH6-2 H3BTB7 EARS2 Probable glutamate--tRNA ligase, mitochondrial 0 58930300.0 11071000.0 32882300.0 14977000.0 False True 16795516.398514625 27014196.65441749 12016789.385347692 1.0 1.6084171521398765 0.7154760294485761 24.001572817874035 -6.72325994138133 1.747664039634882 1.3688589896202754 0.7166131241820698 0.5278321923296858 0.2559268451281378 0.3490157294890963 2.085037132423797 0.11619954284777534 0.2905831148901125 1.8912113195845438e-07 6.72325994138133 -0.6522458654382056 HLLLYQALGWQPPHFAHLPLLLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLLLYQALGWQPPHFAHLPLLLNR 24 0 H3BTB7;Q5JPH6;Q5JPH6-2 H3BTB7 EARS2 Probable glutamate--tRNA ligase, mitochondrial 0 33968800.0 11071000.0 4440800.0 18457000.0 False True 14331627.742035836 4193665.57622307 15098015.384812651 1.0 0.29261613905325673 1.0534752685857822 23.772699139966484 -11.970586611390274 18.35076321030903 0.935018848194471 0.705741133448368 0.0 0.35504909063300777 0.0 0.0 0.0 0.10319351983593063 1.0700729568776497e-12 11.970586611390274 -0.22927771474610303 HLLNVINENFGTLAFCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLLNVINENFGTLAFCR 17 0 P50579;F8VQZ7;P50579-3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 0 43930000.0 10748000.0 14944000.0 18238000.0 False True 16305501.784051578 12277126.441995084 14633251.30600062 1.0 0.752943798025483 0.8974425626271381 23.95885550334905 -10.21703173219365 5.13977745845516 1.0000165300878947 0.8251931804537653 0.6611678972597685 0.05899137362305327 1.1175064425653884e-05 1.7024007352250471e-06 0.05712355094083202 0.019039383967624106 6.066919993652327e-11 10.21703173219365 -0.17482334963412938 HLLNVINENFGTLAFCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLLNVINENFGTLAFCR 17 0 P50579;F8VQZ7;P50579-3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 0 24059600.0 10748000.0 0.0 13311600.0 False True 13913497.874753954 0.0 10889025.388550246 1.0 0.0 0.7826231395275797 23.7299818254415 -10.856425673872886 9.42144209354548 1.0270220222451818 0.39131156976378983 0.44645426174173664 0.3195045587895957 0.14096575177463436 0.0021481880454843868 0.24047060519365424 0.10311965293578773 1.3917919688477382e-11 10.856425673872886 -0.6357104524813919 HLLPTSGAAATAAAAAAAAAAVTAASTSYYGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLLPTSGAAATAAAAAAAAAAVTAASTSYYGR 32 0 Q9BWF3;E9PB51 Q9BWF3 RBM4 RNA-binding protein 4 0 35832700.0 6744700.0 16338000.0 12750000.0 False True 10232203.003618611 13422356.25062335 10229956.91147649 1.0 1.3117757970474728 0.9997804879221681 23.28661345643354 -10.45803100084903 7.143578481109322 0.9999790632898246 1.1557781424848204 0.24947231867906539 0.12737155158315014 4.247729951850751e-05 3.2227165231178985e-06 0.12334353466896071 0.041108991505178286 3.4831245087688685e-11 10.45803100084903 0.1557990791949958 HLLQGWLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLLQGWLR 8 0 Q9BPX3 Q9BPX3 NCAPG Condensin complex subunit 3 0 15769100.0 4545200.0 5217200.0 6006700.0 False True 5958801.215779413 4438814.09648632 5385184.304334978 1.0 0.7449172972462922 0.9037361894326247 22.506590689607954 -10.35916640351952 5.601135158405663 1.0000452176726409 0.824326743543436 0.6199661591537664 0.06483754122843921 3.6620665908811394e-05 4.189812624215832e-06 0.06279481749437804 0.02092622644889784 4.373544970604748e-11 10.35916640351952 -0.17571847412920483 HLLQGWLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLLQGWLR 8 0 Q9BPX3 Q9BPX3 NCAPG Condensin complex subunit 3 0 15405100.0 4545200.0 6274300.0 4585600.0 False True 6225683.269411516 5997080.679664503 3502575.723396489 1.0 0.9632807227970943 0.5626010145112266 22.569800751130845 -6.924812068323273 0.7882176886697584 1.0074041753026575 0.49025119370317144 0.9954164921506556 0.013412027652822405 0.0954226845610718 0.0915444773167695 0.011860814060927231 0.037342065797625446 1.1890166377259206e-07 6.924812068323273 -0.517152981599486 HLLSLMGIPYLDAPSEAEASCAALVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLLSLMGIPYLDAPSEAEASCAALVK 26 0 P39748;P39748-2 P39748 FEN1 Flap endonuclease 1 0 56523000.0 17448000.0 25895000.0 13180000.0 False True 26469891.61966248 21273834.93144154 10574967.223000789 1.0 0.8036993591480677 0.3995092754798228 24.657848951976636 -6.959471893402251 0.4428143973094388 1.0140352833403148 0.17334071552452104 0.9997501063167443 0.003951976531888298 0.07989032264757825 0.021832507965712532 0.005348215782929592 0.033472375556698825 1.0978123360101448e-07 6.959471893402251 -0.8406945678157938 down HLLSLMGIPYLDAPSEAEASCAALVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLLSLMGIPYLDAPSEAEASCAALVK 26 0 P39748;P39748-2 P39748 FEN1 Flap endonuclease 1 0 40234000.0 17448000.0 12619000.0 10167000.0 False True 22586779.95149863 11916741.557007499 8316710.322229512 1.0 0.5275980720844993 0.3682114201355071 24.428975274069085 -13.999999999999998 0.1517286849391731 3.290555392290911 0.19629241976514983 0.99956057223906 0.005623638848643147 11.964635562557348 0.12276224384693737 8.076092098003237 0.1552235693522192 1.0000000000000041e-14 13.999999999999998 -3.0942629725257613 HLLVHAPEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLLVHAPEDK 10 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 6744200.0 1149100.0 2461600.0 3133500.0 False True 1506481.2279002303 2094338.875241648 2809275.4786544456 1.0 1.3902190325735342 1.8647928873100406 20.52275126510157 -6.968508216575422 0.29162296570188884 0.9090531868336531 2.3606544358453245 0.9999682964101005 0.001991023961478451 0.07678977817724449 0.01075371008842559 0.008219477437687748 0.04295631861474727 1.0752062579816346e-07 6.968508216575422 1.4516012490116714 HLLVHAPEDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLLVHAPEDK 10 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 4547260.0 766060.0 1002100.0 2779100.0 False True 741741.8446200436 1402243.7558824625 2051170.3387870993 1.0 1.890474113134011 2.7653426238043894 19.500557633936893 -6.971342608822494 0.22380779571898649 0.6154548035717529 4.065176132548626 0.9999910455099549 0.002156641267089409 0.07586939066780858 0.007451955610960911 0.0235418793402611 0.08797166516261068 1.0682118494009755e-07 6.971342608822494 3.4497213289768736 HLLVHAPEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLLVHAPEDK 10 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 5165500.0 1149100.0 1871900.0 2144500.0 False True 1573953.3232598735 1789193.2684544863 1638013.26736387 1.0 1.1367511615584769 1.0407000278580814 20.58596132662446 -10.120554825154263 5.006613818621103 0.9999964925540527 1.088725594708531 0.5322097006422226 0.039212711131177816 1.535305481627426e-06 2.6975859215608507e-07 0.03796904525353545 0.012655848097432544 7.576090865737036e-11 10.120554825154263 0.08872910215447838 HLLVHAPEDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLLVHAPEDKK 11 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 13542620.0 4390900.0 3329600.0 5822120.0 False True 5756512.421536083 2832836.658679145 5219702.872118599 1.0 0.49210988376938536 0.9067474348862361 22.456763590016813 -9.996548071537937 7.047334394858368 1.0000000254850963 0.6994286593278116 0.4119870148795386 0.169275071405578 6.779720086923493e-08 9.703579921725345e-09 0.16389989777423203 0.054633294373489426 1.0079800310824073e-10 9.996548071537937 -0.30057136615728464 HLLVHAPEDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLLVHAPEDKK 11 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 10562100.0 1484200.0 5952100.0 3125800.0 False True 1437084.8834100044 8328804.569791443 2307059.2080100467 1.0 5.795624646769881 1.6053743481983562 20.454713848417917 -6.613548815779395 2.1407809793971975 4.196274962637329 1.6207992199910954 0.0615632972298954 2.0656813673716625 0.6028544348937351 5.240713541955727 0.7954345609697037 2.2918637241656086 2.434732114628581e-07 6.613548815779395 -2.5754757426462334 HLLVHAPEDKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLLVHAPEDKK 11 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 26705000.0 9331000.0 10283000.0 7091000.0 False True 14155809.187475367 8447918.308554284 5689460.741904287 1.0 0.5967810244312101 0.40191702689367625 23.75489088448246 -13.08271947348227 0.10488994860263519 2.653001563379411 6.677842815461863e-21 0.9997995542650481 0.0035261040650365603 8.725872186538794 0.08797455318670701 3.335302118321304 0.3326082561991129 8.265716897356233e-14 13.08271947348227 -2.653001563379411 HLLVHAPEDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLLVHAPEDKK 11 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 11685300.0 4390900.0 2688100.0 4606300.0 False True 6014334.389610801 2569330.853642022 3518386.809726367 1.0 0.4272011975390494 0.5850001981605896 22.519973651539704 -10.611721944745208 9.906516373850542 1.0000703324102267 0.5061006978499394 0.9288859621989038 0.06442117224064983 0.00010008472252861403 3.922757629248522e-06 0.062384253697716455 0.02079184393593303 2.4449954499559775e-11 10.611721944745208 -0.4939696345602873 HLLVHAPEDKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLLVHAPEDKK 11 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 3867030.0 1484200.0 1606700.0 776130.0 False True 1234178.0612084311 1598044.3881950185 938415.1945803383 1.0 1.2948248218172926 0.7603564056725332 20.235119123852193 -6.756952803923788 1.6238451256703326 1.1719007204032048 0.7586876995392045 0.6784076985864798 0.12395653804802939 0.28808520919713887 1.4964411106871074 0.06024849326649787 0.1452311062872499 1.750036860014595e-07 6.756952803923788 -0.41321302086400036 HLLVHAPEDKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLLVHAPEDKK 11 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 28145630.0 9331000.0 6402630.0 12412000.0 False True 12079163.441508105 6046318.012135897 10153143.357874753 1.0 0.5005576786351525 0.8405502092127595 23.52601720657491 -10.077115360928635 5.590417084876891 1.0000022828336161 0.6705539439238651 0.5559299620992668 0.13880136937911938 3.949215797691963e-06 6.519776332534231e-07 0.1343947791147042 0.044797949336295 8.373068401465069e-11 10.077115360928635 -0.329448338909751 HLMTLVMDPLQTASVQWFER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLMTLVMDPLQTASVQWFER 20 0 P30566;A0A0A6YY92;A0A1B0GTJ7;A0A1B0GWJ0;A0A096LNY6;P30566-2;A0A1B0GWF8;A0A1B0GTG9 P30566 ADSL Adenylosuccinate lyase 0 23368300.0 11248000.0 6180700.0 5939600.0 False True 14560757.731227448 5836738.61172804 4858653.745442552 1.0 0.40085404341357805 0.3336813808132068 23.79558209850087 -13.999999999999998 0.3089216944944856 6.755157934647019 0.3186329232834713 0.9996696234251518 0.005444348677301437 17.19334712645639 0.1768077552829958 63.56664540501391 0.023381104110844188 1.0000000000000041e-14 13.999999999999998 -6.436525011363548 HLNDDDVTGSVK(ub)SER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLNDDDVTGSVKSER 15 1 O75379-2;O75379 O75379-2 VAMP4 Vesicle-associated membrane protein 4 1 3518680.0 1590000.0 1244500.0 684180.0 True False 2058286.3435856719 1175242.4809965796 559666.2602796294 1.0 0.5709810419036396 0.2719088439874957 20.97301226960005 -8.14943616191066 0.24116479557044448 1.2046331550456781 9.633218880583063e-12 0.9995898077180306 0.006051975565031122 0.08839143991155396 0.04960890341083728 0.08644051996378993 0.1031573820758993 7.088654967991191e-09 8.14943616191066 -1.204633155036045 down HLNDETTSK(ub)QIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLNDETTSKQIK 12 1 Q9NUQ9;Q9NUQ9-2 Q9NUQ9 FAM49B Protein FAM49B 1 4604100.0 1393400.0 2050700.0 1160000.0 True False 1826760.893704793 1744743.553565994 1039974.3275057162 1.0 0.9551023122832116 0.5692996445728477 20.800856380059557 -6.928791080652485 0.7566545661163419 1.0061377741252022 0.4924820816169796 0.9962951377664733 0.011767071153699779 0.0932706663382099 0.08079271537516007 0.010644224259246412 0.03514349042545536 1.1781726025409971e-07 6.928791080652485 -0.5136556925082226 HLNDETTSK(ub)QIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLNDETTSKQIK 12 1 Q9NUQ9;Q9NUQ9-2 Q9NUQ9 FAM49B Protein FAM49B 1 6902000.0 2507800.0 1677100.0 2717100.0 True False 2428191.261700315 2346774.775960961 2005409.9987472289 1.0 0.966470315982299 0.825886341977428 21.21145063236714 -6.943794348149396 0.6232658963283992 1.001535772901114 0.7833311681057638 0.9986198251821586 0.002802175774765983 0.08607750749519195 0.04704179952597705 0.002813654938536431 0.01191248276952219 1.1381661150455806e-07 6.943794348149396 -0.2182046047953503 HLNDETTSK(ub)QIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLNDETTSKQIK 12 1 Q9NUQ9;Q9NUQ9-2 Q9NUQ9 FAM49B Protein FAM49B 1 8573000.0 1870300.0 2721300.0 3981400.0 True False 2837381.8372452254 2235662.753386057 3194474.5448903865 1.0 0.7879315797540422 1.1258528911962928 21.43612888194977 -6.737047980774284 1.697453579419441 0.8733903667722435 1.1259279310024095 0.5916277725793404 0.08911058922210618 0.3231896291986265 1.8272743758962686 0.04154940919894176 0.10229277527317379 1.8321119997936884e-07 6.737047980774284 0.25253756423016605 HLNDETTSK(ub)QIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLNDETTSKQIK 12 1 Q9NUQ9;Q9NUQ9-2 Q9NUQ9 FAM49B Protein FAM49B 1 5411400.0 1393400.0 2191700.0 1826300.0 True False 1908577.6352191318 2094863.4470173044 1394965.5538291628 1.0 1.0976045241024657 0.7308927486562531 20.864066441582448 -6.835893635989414 1.3011916632853273 1.051984214390753 0.7197698039712589 0.9171767891533278 0.04462789078246275 0.17365587149832845 0.572872735442979 0.02690949649366941 0.06194725606916506 1.4591715854184987e-07 6.835893635989414 -0.33221441041949407 HLNDETTSK(ub)QIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLNDETTSKQIK 12 1 Q9NUQ9;Q9NUQ9-2 Q9NUQ9 FAM49B Protein FAM49B 1 6909200.0 2507800.0 3266200.0 1135200.0 True False 2085346.8143771067 3248604.3323100633 1372565.07142824 1.0 1.557824487472805 0.6581951078666142 20.991855907801416 -6.739029278040427 1.6906515030243254 1.3322801485422537 0.657819107941897 0.6004313019653085 0.23437838393478067 0.31956222490319997 1.7931756999192832 0.10969809638173626 0.2694349303998208 1.8237727482081223e-07 6.739029278040427 -0.6744610406003567 HLNEIDLFHCIDPNDSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLNEIDLFHCIDPNDSK 17 0 Q15185-4;Q15185;A0A087WYT3;Q15185-3 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 31235800.0 18661000.0 5389000.0 7185800.0 False True 18068616.769514985 7540855.803263754 5303623.410620823 1.0 0.41734549464719056 0.29352680829276273 24.106982730118293 -13.999999999999998 0.21767583802612184 4.480589516844249 0.2258027234395164 0.9994956735936691 0.006917409338397486 12.937424016381252 0.1478206368907065 19.332677567602286 0.0695900560635383 1.0000000000000041e-14 13.999999999999998 -4.254786793404733 HLNEIDLFHCIDPNDSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLNEIDLFHCIDPNDSK 17 0 Q15185-4;Q15185;A0A087WYT3;Q15185-3 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 199748900.0 22857000.0 158257900.0 18634000.0 False True 34675740.070531 130015541.27038349 14950981.73242767 1.0 3.749466947379633 0.4311654690575352 25.047423337955546 -6.686700422238534 1.8780906952457916 2.729048532453583 0.44306048080451016 0.35503363682811695 1.1636229808808214 0.4238088505133877 2.895621940423629 0.49613005089720175 1.2973799891446829 2.0573092453147272e-07 6.686700422238534 -2.285988051649073 HLNEIDLFHCIDPNDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLNEIDLFHCIDPNDSK 17 0 Q15185-4;Q15185;A0A087WYT3;Q15185-3 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 131611000.0 30572000.0 55624000.0 45415000.0 False True 41875294.57723509 53166347.75602979 34688912.35128475 1.0 1.2696351940395167 0.8283861093157034 25.31959600353191 -6.741334687194442 1.6817714233786754 1.1601852670735 0.8280505017623092 0.6109048468752023 0.11328671940473088 0.31542261983681424 1.7521940063587356 0.053278115908063195 0.1305505886053959 1.8141170823273663e-07 6.741334687194442 -0.3321347653111908 HLNEIDLFHCIDPNDSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLNEIDLFHCIDPNDSK 17 0 Q15185-4;Q15185;A0A087WYT3;Q15185-3 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 32001000.0 18661000.0 0.0 13340000.0 False True 15517448.322470402 0.0 16129332.322808947 1.0 0.0 1.0394319985878409 23.88738800555257 -10.489220529722132 5.017259485111533 1.0013145738156863 0.5197159992939026 0.22159042105977478 0.4243463364769863 0.00625546761524434 0.0006368343512502017 0.41190034853047475 0.13695719118328217 3.2417496324580456e-11 10.489220529722132 -0.4815985745217838 HLNEIDLFHCIDPNDSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLNEIDLFHCIDPNDSK 17 0 Q15185-4;Q15185;A0A087WYT3;Q15185-3 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 64375000.0 22857000.0 21964000.0 19554000.0 False True 29588837.07882875 20741684.0920923 15995372.640983155 1.0 0.7009969346491581 0.540588080510541 24.818549660047996 -13.999999999999643 0.07690185669258148 2.644351826333454 0.03285509314733483 0.9998991510329864 0.0019118327967665944 12.289544665067387 0.07711366109831011 3.489102770626042 0.46295919963057214 1.0000000000008221e-14 13.999999999999643 -2.611496733186119 HLNEIDLFHCIDPNDSK(ub)HK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLNEIDLFHCIDPNDSKHK 19 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 107969000.0 28902000.0 26337000.0 52730000.0 True False 43846447.019227706 21636956.578079794 42307892.38761996 1.0 0.49347114872480946 0.9649103921480102 25.38595660664402 -10.5636218010974 9.350469075656946 1.0000225072589453 0.7291907704364099 0.3055367553619589 0.19246426518509868 9.031177265599895e-05 4.2147996444211565e-06 0.18636816721624605 0.06211757448349454 2.7313553076652465e-11 10.5636218010974 -0.27083173682253536 HLNLAENSSYIHVYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLNLAENSSYIHVYR 15 0 F6U236;Q9BY11 F6U236 PACSIN1 Protein kinase C and casein kinase substrate in neurons protein 1 0 21106800.0 10214000.0 6038600.0 4854200.0 False True 13390652.912516696 5137664.418278446 4351933.94877435 1.0 0.38367542283738065 0.3249978904842235 23.674722970705375 -13.999999999999998 0.3326177912487071 7.815932879660049 0.31492193283821224 0.9997202496734847 0.00510652926386412 19.04677768265686 0.18456693891428333 90.94059686602918 0.0186215270809054 1.0000000000000041e-14 13.999999999999998 -7.501010946821837 HLNLAENSSYIHVYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLNLAENSSYIHVYR 15 0 F6U236;Q9BY11 F6U236 PACSIN1 Protein kinase C and casein kinase substrate in neurons protein 1 0 17673300.0 6656400.0 4033900.0 6983000.0 False True 6445096.22552914 5644657.306510604 5153942.814490412 1.0 0.8758065215771359 0.7996688698107491 22.619770467563136 HLNLAENSSYIHVYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLNLAENSSYIHVYR 15 0 F6U236;Q9BY11 F6U236 PACSIN1 Protein kinase C and casein kinase substrate in neurons protein 1 0 18902600.0 10214000.0 8688600.0 0.0 False True 13990391.82297131 8304708.922642053 0.0 1.0 0.5936008817856169 0.0 23.737933032228266 -7.667710529435287 0.6565895422606908 0.9989748072544529 4.835430645096102e-15 0.9873392896137512 0.04620354654200853 0.12076094638452713 0.14963225343537337 0.0426395015933744 0.0776965148354542 2.149262546087428e-08 7.667710529435287 -0.998974807254448 down HLNLAENSSYIHVYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLNLAENSSYIHVYR 15 0 F6U236;Q9BY11 F6U236 PACSIN1 Protein kinase C and casein kinase substrate in neurons protein 1 0 15191400.0 6656400.0 5719200.0 2815800.0 False True 5535091.52851893 5688389.534427683 3404570.7612117957 1.0 1.0276956587111346 0.6150884305471972 22.400175742997412 -6.890841249901745 1.0174110693843756 1.0217248799369105 0.5790123284153614 0.9814306544096766 0.025661803482734384 0.11846252169218066 0.21789085151960916 0.019197135919526452 0.04800517832442284 1.2857565638646428e-07 6.890841249901745 -0.4427125515215491 HLNSILVLDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLNSILVLDLR 11 0 Q9H9A6 Q9H9A6 LRRC40 Leucine-rich repeat-containing protein 40 0 44250000.0 14160000.0 18973000.0 11117000.0 False True 21481755.23466417 15587119.91327439 8919720.0772458 1.0 0.7255980595162046 0.4152230569526478 24.356608542306244 -6.969524053970856 0.26931419124346084 1.0778012741146914 0.05369762221713672 0.9999784271646277 0.0011095224333025927 0.07645748163431916 0.009581572112217312 0.006109698201480674 0.02889392101397232 1.0726942336097559e-07 6.969524053970856 -1.0241036518975546 down HLNSILVLDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLNSILVLDLR 11 0 Q9H9A6 Q9H9A6 LRRC40 Leucine-rich repeat-containing protein 40 0 29638900.0 14160000.0 8891200.0 6587700.0 False True 18330399.135329 8396396.904007064 5388806.1955101155 1.0 0.4580585966523943 0.293981934366286 24.127734864398693 -13.999999999999998 0.16740029685200147 3.7149273970895926 0.14516796156635153 0.9995188813829929 0.006617114594159496 12.067295164693373 0.12950813979076536 10.636556843275812 0.13700360284710814 1.0000000000000041e-14 13.999999999999998 -3.569759435523241 HLPGVCK(ub)VSTDLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLPGVCKVSTDLLR 14 1 Q96HS1;Q96HS1-2;F5GXG4 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 116210000.0 18638000.0 24457000.0 73115000.0 True False 28275208.620315697 20092457.266586807 58663788.20255702 1.0 0.7106033252094347 2.074742895456735 24.7530343329672 -6.851276412152882 1.2290660295967024 0.845395529785668 2.130586118693276 0.9421210738806923 0.141188320933721 0.15606097875231675 0.45303671671726575 0.08986310436313258 0.20810600690787767 1.4083921243261245e-07 6.851276412152882 1.285190588907608 up HLPGVCK(ub)VSTDLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLPGVCKVSTDLLR 14 1 Q96HS1;Q96HS1-2;F5GXG4 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 34690200.0 15958000.0 10220000.0 8512200.0 True False 13269784.05926705 10164942.831488838 10292061.664034039 1.0 0.7660217216865769 0.7756012922340287 23.661641557967165 -9.90508310133476 5.245953447556044 1.0000004133421723 0.7708115069598767 0.9986914208592238 0.003910843308862455 5339496.664321545 0.8778335429576363 26.656609000245343 0.0013387856855074408 1.244276499302476e-10 9.90508310133476 -0.2291889063822956 HLPGVCK(ub)VSTDLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLPGVCKVSTDLLR 14 1 Q96HS1;Q96HS1-2;F5GXG4 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 62853000.0 18638000.0 20512000.0 23703000.0 True False 24127258.409905475 19370489.168502852 19389297.213318206 1.0 0.8028466740568533 0.8036262091576019 24.52416065505965 -10.140018801239032 5.0428404054823535 1.0000090614209125 0.8032364416963251 0.9999882244532675 0.0003182438735346984 3.242319410481514e-08 5.529200461150375e-09 0.0003081524924481448 0.00010271276833348761 7.244045988687133e-11 10.140018801239032 -0.19677261972458737 HLPK(ub)SIYSQIQEQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLPKSIYSQIQEQR 14 1 A0A087WT20;Q9NV06 A0A087WT20 DCAF13 DDB1- and CUL4-associated factor 13 1 6043300.0 1777400.0 1876300.0 2389600.0 True False 1720977.4098995698 2625516.3747752416 1763692.0735366335 1.0 1.5255960709725165 1.0248200025121517 20.71479672954961 -10.598123548092207 2.792797790410103 0.9792688028373795 1.2752080361510523 0.28708545672447716 0.20444098129184946 130966628.76338312 124520567.79573283 19877116.820496984 0.07964768553003498 2.5227629947836053e-11 10.598123548092207 0.2959392333136728 HLPSTEPDPHVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLPSTEPDPHVVR 13 0 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;M0QYZ0;M0QYM5;M0QYI8 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 0 8158700.0 4552100.0 826100.0 2780500.0 False True 4407596.077193557 1155966.0380545876 2052203.6367879978 1.0 0.26226678166721307 0.4656061038366961 22.07156058721449 -10.30703858906424 6.3117667056967095 1.0000268961273178 0.36393644275288345 0.928808344906813 0.08301293065977283 3.142001042314431e-05 3.449715750367352e-06 0.08038031002352722 0.026792308163764156 4.9312998513862815e-11 10.30703858906424 -0.6360904533744343 HLPSTEPDPHVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLPSTEPDPHVVR 13 0 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;M0QYZ0;M0QYM5;M0QYI8 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 0 3656460.0 619560.0 0.0 3036900.0 False True 802032.6333534204 0.0 2484215.361225415 1.0 0.0 3.097399354984513 19.613301413136124 -6.81980236268138 1.372719910768544 0.4608738018499557 3.164742063255872 0.8839227656262101 0.43974009029196454 0.19374247424937235 0.7174157873864667 0.25173528155397873 0.5802426648342874 1.5142501917096376e-07 6.81980236268138 2.7038682614059164 HLQDASGTDGK(ub)VAVNLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLQDASGTDGKVAVNLAK 18 1 M0R2E1;M0QZW9;M0R3H4;G5E9L6;Q9NPR9 M0R2E1 GPR108 Protein GPR108 1 18509700.0 3609400.0 7509300.0 7391000.0 True False 5475723.682485658 6169206.744571313 5930165.610409615 1.0 1.1266468328750392 1.082992122005263 22.384618216072347 -10.311024576816546 4.283066632731861 0.9998826415555419 1.1048194774417617 0.8848862955171469 0.017821961088695125 1.999454686229612e-05 3.2163408728997985e-06 0.017275337443580535 0.005752013207020089 4.886247071849392e-11 10.311024576816546 0.10493683588621983 HLQDASGTDGK(ub)VAVNLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLQDASGTDGKVAVNLAK 18 1 M0R2E1;M0QZW9;M0R3H4;G5E9L6;Q9NPR9 M0R2E1 GPR108 Protein GPR108 1 14571600.0 3609400.0 5304900.0 5657300.0 True False 4672439.451910773 5009677.651618117 4627729.448799939 1.0 1.0721760449072124 0.990431121992913 22.155744538164797 -6.6735991057788535 1.9243657774564762 1.0459254388381236 0.9907539042646016 0.2952057024625351 0.03063345111296076 0.4528990406592239 3.236687616472601 0.012799206744246092 0.03403966511748544 2.1203174825120553e-07 6.6735991057788535 -0.055171534573521974 HLQEASATDGK(ub)AAINLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLQEASATDGKAAINLAK 18 1 Q5VW38-2 Q5VW38-2 1 13877400.0 2674000.0 7055700.0 4147700.0 True False 4056653.4955855925 5796555.208564288 3327905.2769985073 1.0 1.4289007466060482 0.8203572921916794 21.951858647429237 -6.717318770490726 1.7689830838123026 1.261680748805349 0.821446332573966 0.49984506513547167 0.18054458411819024 0.3605432865667179 2.203485208557409 0.08108499555168967 0.2041968576277983 1.9172609618592287e-07 6.717318770490726 -0.44023441623138293 HLQEASATDGK(ub)AAINLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLQEASATDGKAAINLAK 18 1 Q5VW38-2 Q5VW38-2 1 12010600.0 2674000.0 5172000.0 4164600.0 True False 3461545.71242018 4884173.653446611 3406685.5324045434 1.0 1.4109805443048111 0.9841515367488011 21.722984969521686 -6.654810702027793 1.9916978840849353 1.2656711563840277 0.9859559183364253 0.2136480318521291 0.17520662664797262 0.49685300690715817 3.7832724568630396 0.07121548159102428 0.1940857187301489 2.214059551833656e-07 6.654810702027793 -0.27971523804760245 HLQLAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLQLAIR 7 0 Q71UI9;P0C0S5;Q71UI9-3;Q71UI9-4;A0A494C189;C9J0D1;Q71UI9-2;C9J386;A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q9BTM1-2;A0A3B3IS11;Q93077;Q7L7L0;P04908;P16104;Q96QV6;Q16777 Q71UI9;A0A0U1RR32;Q93077;P16104;Q16777 H2AFV;H2AFZ;HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;H2AFX;HIST1H2AA;HIST2H2AC Histone H2A.V;Histone H2A.Z;Histone H2A;Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2AX;Histone H2A type 1-A;Histone H2A type 2-C 0 5000980160.0 1785303460.0 1357398800.0 1858277900.0 False True 2340550124.9633 1154880190.1390808 1666001128.768302 1.0 0.4934225410605933 0.7117989531603921 31.12420051596483 -10.288587685500469 5.689553747750479 1.0000356120945362 0.602610747110489 0.8153377812014144 0.08915179691739036 4.0275955085053074e-05 5.036102924774996e-06 0.08632857196582702 0.02877361872879098 5.145319108213296e-11 10.288587685500469 -0.39742486498404717 HLQLAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLQLAIR 7 0 Q71UI9;P0C0S5;Q71UI9-3;Q71UI9-4;A0A494C189;C9J0D1;Q71UI9-2;C9J386;A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q9BTM1-2;A0A3B3IS11;Q93077;Q7L7L0;P04908;P16104;Q96QV6;Q16777 Q71UI9;A0A0U1RR32;Q93077;P16104;Q16777 H2AFV;H2AFZ;HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;H2AFX;HIST1H2AA;HIST2H2AC Histone H2A.V;Histone H2A.Z;Histone H2A;Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2AX;Histone H2A type 1-A;Histone H2A type 2-C 0 3393371160.0 1753098300.0 576053260.0 1064219600.0 False True 1697447154.0639932 806074330.7960653 785468560.856346 1.0 0.4748744777510031 0.462735207382329 30.660719514313953 HLQLAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLQLAIR 7 0 Q71UI9;P0C0S5;Q71UI9-3;Q71UI9-4;A0A494C189;C9J0D1;Q71UI9-2;C9J386;A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q9BTM1-2;A0A3B3IS11;Q93077;Q7L7L0;P04908;P16104;Q96QV6;Q16777 Q71UI9;A0A0U1RR32;Q93077;P16104;Q16777 H2AFV;H2AFZ;HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;H2AFX;HIST1H2AA;HIST2H2AC Histone H2A.V;Histone H2A.Z;Histone H2A;Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2AX;Histone H2A type 1-A;Histone H2A type 2-C 0 3508115300.0 46309600.0 57153500.0 3404652200.0 False True 70255048.88525452 46954011.382666275 2731721200.357932 1.0 0.6683364701568263 38.88291651208686 26.066098572676484 -6.9019800266611115 0.9494756138832097 5.704183364338972e-14 43.04692100558853 0.9889573923444444 1.8848739499460885 0.10580203545395306 0.16327571240346056 1.5098149038495359 3.965141173484457 1.2531988086207954e-07 6.9019800266611115 43.04692100558847 up HLQLAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLQLAIR 7 0 Q71UI9;P0C0S5;Q71UI9-3;Q71UI9-4;A0A494C189;C9J0D1;Q71UI9-2;C9J386;A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q9BTM1-2;A0A3B3IS11;Q93077;Q7L7L0;P04908;P16104;Q96QV6;Q16777 Q71UI9;A0A0U1RR32;Q93077;P16104;Q16777 H2AFV;H2AFZ;HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;H2AFX;HIST1H2AA;HIST2H2AC Histone H2A.V;Histone H2A.Z;Histone H2A;Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2AX;Histone H2A type 1-A;Histone H2A type 2-C 0 5047093160.0 1785303460.0 1831801400.0 1429988300.0 False True 2445378395.173918 1750866357.1908247 1092254515.0734935 1.0 0.7159899509402108 0.44666073652614047 31.18741057748772 -6.971768679759657 0.2117252131728998 1.1379426490175901 0.01717478323643755 0.9999930871570198 0.0005939838528683435 0.07573289134837921 0.006938094664543357 0.007955787086854228 0.02779871928049089 1.0671643784848693e-07 6.971768679759657 -1.1207678657811526 down HLQLAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLQLAIR 7 0 Q71UI9;P0C0S5;Q71UI9-3;Q71UI9-4;A0A494C189;C9J0D1;Q71UI9-2;C9J386;A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q9BTM1-2;A0A3B3IS11;Q93077;Q7L7L0;P04908;P16104;Q96QV6;Q16777 Q71UI9;A0A0U1RR32;Q93077;P16104;Q16777 H2AFV;H2AFZ;HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;H2AFX;HIST1H2AA;HIST2H2AC Histone H2A.V;Histone H2A.Z;Histone H2A;Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2AX;Histone H2A type 1-A;Histone H2A type 2-C 0 3680957300.0 1753098300.0 1284804800.0 643054200.0 False True 1457778911.8729267 1277883301.5286145 777513860.073317 1.0 0.8765960950051159 0.5333551293277949 30.44112478974823 -6.953137944559483 0.5232642592813084 1.0056888811058928 0.3888590770226769 0.9994250716091966 0.004733858696433717 0.0822496891018041 0.030933309920719104 0.005335413683939933 0.028361449064727994 1.1139406574407826e-07 6.953137944559483 -0.6168298040832159 HLQLAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLQLAIR 7 0 Q71UI9;P0C0S5;Q71UI9-3;Q71UI9-4;A0A494C189;C9J0D1;Q71UI9-2;C9J386;A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q9BTM1-2;A0A3B3IS11;Q93077;Q7L7L0;P04908;P16104;Q96QV6;Q16777 Q71UI9;A0A0U1RR32;Q93077;P16104;Q16777 H2AFV;H2AFZ;HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;H2AFX;HIST1H2AA;HIST2H2AC Histone H2A.V;Histone H2A.Z;Histone H2A;Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2AX;Histone H2A type 1-A;Histone H2A type 2-C 0 154230900.0 46309600.0 60141400.0 47779900.0 False True 59948690.0986887 56794478.22146056 39084448.463174425 1.0 0.9473848073738456 0.6519650120600274 25.837224894768934 -6.937255553339755 0.684619991062958 1.003525745380448 0.5783451696241808 0.9977818661300117 0.007214199494132269 0.0890413523997834 0.060480501892946244 0.0068842172731594705 0.025748685594568638 1.1554321473528713e-07 6.937255553339755 -0.4251805757562672 HLQLAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLQLAVR 7 0 Q8IUE6 Q8IUE6 HIST2H2AB Histone H2A type 2-B 0 105178000.0 41634000.0 30168000.0 33376000.0 False True 54582577.18422947 25667051.99394297 29922571.685198918 1.0 0.4702425813883875 0.5482073809780539 25.70193717907146 -10.686942425511123 6.750646766094595 1.003780431248068 0.5092249811833292 0.9814240845279607 0.031828996148838995 0.0018186335050745701 8.433808086529159e-05 0.030948688331248413 0.010272764334246124 2.0561631637958122e-11 10.686942425511123 -0.4945554500647389 HLQLAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLQLAVR 7 0 Q8IUE6 Q8IUE6 HIST2H2AB Histone H2A type 2-B 0 53432000.0 22409000.0 14470000.0 16553000.0 False True 21697638.56106645 20247946.46005314 12217272.72064442 1.0 0.9331866416276935 0.5630692338366584 24.371034701276603 -6.937548261631906 0.6819969394537542 1.004383244106103 0.47007189929136683 0.9978247143792424 0.008962739887688368 0.08890338749181105 0.059839376309878387 0.008570222977860503 0.03221451772912906 1.1546536649228462e-07 6.937548261631906 -0.5343113448147361 HLQLAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLQLAVR 7 0 Q8IUE6 Q8IUE6 HIST2H2AB Histone H2A type 2-B 0 257533000.0 70434000.0 127730000.0 59369000.0 False True 106853527.41513668 104935583.54095496 47634691.12764291 1.0 0.9820507200784274 0.4457942782045683 26.67105929367899 -6.914013998538095 0.8679483622480013 1.0145709582383466 0.3701942264432507 0.992350287130107 0.022489165033247265 0.10182339253254981 0.12481040805797962 0.01878567732956868 0.05341953140696645 1.2189503080795074e-07 6.914013998538095 -0.6443767317950959 down HLQLAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLQLAVR 7 0 Q8IUE6 Q8IUE6 HIST2H2AB Histone H2A type 2-B 0 116329000.0 41634000.0 32896000.0 41799000.0 False True 57027214.91654466 31442545.947475135 31926937.077427085 1.0 0.551360363529748 0.5598543980124213 25.765147240594352 -10.15244043541409 5.272709072447638 1.0000150949553117 0.5556073807708528 0.999726071102041 0.003467675057504368 6.15346259257157e-07 9.89177511055856e-08 0.003357675895258308 0.0011191873121973509 7.039787737837453e-11 10.15244043541409 -0.4444077141844589 HLQLAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLQLAVR 7 0 Q8IUE6 Q8IUE6 HIST2H2AB Histone H2A type 2-B 0 65087000.0 22409000.0 29376000.0 13302000.0 False True 18634076.38702315 29217745.65732052 16083386.69850108 1.0 1.5679739124428986 0.8631169243087153 24.15143997671088 -6.692246061573266 1.8584192668075317 1.3553319653767355 0.8654841866256969 0.380958940052026 0.24010464923887886 0.4118626428796343 2.759608976393436 0.10328995143003579 0.2682167514373413 2.0312058488960923e-07 6.692246061573266 -0.4898477787510386 HLQLAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLQLAVR 7 0 Q8IUE6 Q8IUE6 HIST2H2AB Histone H2A type 2-B 0 242953000.0 70434000.0 104640000.0 67879000.0 False True 91178201.46170637 98816692.0140475 55525718.49735581 1.0 1.0837754027814335 0.6089801905192863 26.44218561577144 -6.861322865713756 1.1789164178312195 1.045627861426076 0.5853877396381711 0.955235466226044 0.04377950122665191 0.1454517727904221 0.3833664199447442 0.02894614999723939 0.06767806840267483 1.3761859963560252e-07 6.861322865713756 -0.46024012178790497 HLQLSFQEPHFYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLQLSFQEPHFYLR 14 0 P85037 P85037 FOXK1 Forkhead box protein K1 0 94956000.0 30332000.0 31744000.0 32880000.0 False True 46015861.56623116 26079035.182995956 26381253.588184077 1.0 0.5667401260206788 0.5733078266982622 25.455627904915097 -10.05714029858365 7.456569300131381 1.0000000400816462 0.5700239763597219 0.9998250453403916 0.0026812525739018634 1.784789592048901e-09 2.2827437976456346e-10 0.0025961118735336225 0.0008653705471414638 8.767175522880226e-11 10.05714029858365 -0.4299760637219243 HLQLSFQEPHFYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLQLSFQEPHFYLR 14 0 P85037 P85037 FOXK1 Forkhead box protein K1 0 18024600.0 4046800.0 7036700.0 6941100.0 False True 5543011.320657958 6725795.326744838 5301755.136441761 1.0 1.2133829317069629 0.9564756104110643 22.40223852341134 -6.686230330411852 1.8798968198917185 1.13424938359437 0.9574042296902836 0.35277252882632526 0.0903165607362949 0.4248396063251641 2.9079045111573723 0.03847759802317302 0.10067385940201119 2.0595373368766492e-07 6.686230330411852 -0.1768451539040865 HLQLSFQEPHFYLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLQLSFQEPHFYLR 14 0 P85037 P85037 FOXK1 Forkhead box protein K1 0 98186000.0 30332000.0 37448000.0 30406000.0 False True 39265371.93310727 35363985.8805624 24872419.991906196 1.0 0.9006405425322013 0.6334441460093387 25.226754227007547 -6.953880214911371 0.5144856867992704 1.0047417123978901 0.5175306521489511 0.9994716550313256 0.003557877240634232 0.08196405562838899 0.029796130878088196 0.004066948053753083 0.022059651331993124 1.1120384022584422e-07 6.953880214911371 -0.487211060248939 HLQVNVTNPVQCSLHGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLQVNVTNPVQCSLHGK 17 0 K7EIG7;O94832 K7EIG7 MYO1D Unconventional myosin-Id 0 7162700.0 2165200.0 2434700.0 2562800.0 False True 2838598.167826627 2071452.2503862681 2297626.04011349 1.0 0.7297447993395543 0.8094227869782175 21.43674720482024 -10.134921951793276 7.199849399213241 1.0000001361699749 0.7695837931588859 0.9176977667269044 0.0325284022410851 7.110471524294166e-08 8.539193782130311e-09 0.03149550834291618 0.010498496679871539 7.32956242803052e-11 10.134921951793276 -0.23041634301108893 HLQVNVTNPVQCSLHGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLQVNVTNPVQCSLHGK 17 0 K7EIG7;O94832 K7EIG7 MYO1D Unconventional myosin-Id 0 5140700.0 2165200.0 1267500.0 1708000.0 False True 2965732.9523298903 1211497.6589380098 1304605.5773641847 1.0 0.40849856626040887 0.4398931388408663 21.49995726634313 -9.96367458111532 5.24854983793208 1.0000017699368495 0.4241958525627395 0.9977753908828353 0.012816780598792765 7646876.393063373 14516577.80475017 121.02845587269405 0.004387525129923737 1.0872399924806316e-10 9.96367458111532 -0.57580591737411 HLSGNQFILELFHGPTGSFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLSGNQFILELFHGPTGSFK 20 0 Q8IYQ7 Q8IYQ7 THNSL1 Threonine synthase-like 1 0 9079400.0 3943300.0 1822700.0 3313400.0 False True 3818122.0999532947 2550513.6152549316 2445521.1401306787 1.0 0.6680021090174488 0.6405036497289056 21.86443180883409 -13.999999999999966 0.3529296514118927 5.157386511579741 0.6368505370803202 0.9997602501595445 0.002529636368822921 20.955332222785184 0.19145524780679576 65.40412776040735 0.008123517472928086 1.0000000000000778e-14 13.999999999999966 -4.5205359744994205 HLSGNQFILELFHGPTGSFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLSGNQFILELFHGPTGSFK 20 0 Q8IYQ7 Q8IYQ7 THNSL1 Threonine synthase-like 1 0 21486200.0 6166400.0 7539100.0 7780700.0 False True 9354879.624225495 6193688.70174285 6242841.2345980415 1.0 0.6620810689753408 0.6673352822661143 23.15728765874424 -10.191875085699294 5.7778268459485735 1.000007181527061 0.6647081756208516 0.9998158575573373 0.002145023593720419 1.9843791929261663e-07 2.7755394595719194e-08 0.0020769546335548997 0.0006923033879707817 6.428725974770514e-11 10.191875085699294 -0.3352990059062094 HLSGNQFILELFHGPTGSFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLSGNQFILELFHGPTGSFK 20 0 Q8IYQ7 Q8IYQ7 THNSL1 Threonine synthase-like 1 0 7521340.0 904640.0 2120200.0 4496500.0 False True 1239109.8549767735 2026522.5534361855 3434519.308324385 1.0 1.6354664159088395 2.7717633707212856 20.2408726665723 -6.962174191556847 0.4036249749973173 0.9399797493331883 3.5089846607682236 0.9998425297157569 0.009196811766374664 0.07893341387805795 0.018327440114858335 0.014617984033709085 0.09507760107241747 1.0910026574618208e-07 6.962174191556847 2.5690049114350355 HLSGNQFILELFHGPTGSFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLSGNQFILELFHGPTGSFK 20 0 Q8IYQ7 Q8IYQ7 THNSL1 Threonine synthase-like 1 0 8759300.0 3943300.0 1765000.0 3051000.0 False True 3279028.6678097383 1755491.594674932 3688949.993769869 1.0 0.5353693951835838 1.1250130351052838 21.644837084268367 -6.696609747506402 1.842906061792288 0.7105306046991883 1.123154803133241 0.4015283700687181 0.1962505405516335 0.4026175396829877 2.65599164952814 0.08503192057700995 0.2196038422512726 2.0108989738411558e-07 6.696609747506402 0.41262419843405274 HLSGNQFILELFHGPTGSFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLSGNQFILELFHGPTGSFK 20 0 Q8IYQ7 Q8IYQ7 THNSL1 Threonine synthase-like 1 0 11383500.0 6166400.0 5217100.0 0.0 False True 7982526.357916147 4926763.798800528 0.0 1.0 0.6171935522536337 0.0 22.92841398083669 -7.609945535156325 0.6748043319128196 0.9968060688759802 4.061767000365073e-21 0.9871501992241845 0.04669959272066746 0.12119659523965585 0.14701911570514142 0.042363967085588254 0.07722456453450396 2.455016779880049e-08 7.609945535156325 -0.9968060688759802 down HLSK(ub)MQQNGYENPTYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLSKMQQNGYENPTYK 16 1 A0A0A0MRG2;E9PG40;P05067-10;P05067-3;P05067-4;P05067-5;P05067-6;P05067-7;P05067-11;P05067-8;P05067-9;P05067 A0A0A0MRG2 APP Amyloid beta A4 protein;N-APP;Soluble APP-alpha;Soluble APP-beta;C99;Beta-amyloid protein 42;Beta-amyloid protein 40;C83;P3(42);P3(40);C80;Gamma-secretase C-terminal fragment 59;Gamma-secretase C-terminal fragment 57;Gamma-secretase C-terminal fragment 50;C31 1 14761600.0 5787000.0 6421300.0 2553300.0 True False 7586813.041387716 5463267.070031358 2289109.0089830514 1.0 0.7201003952816614 0.3017220796789724 22.85506255576322 -7.0332776698000075 0.3657421429254635 1.0353961469933086 2.078967807777299e-11 0.9999099803449368 0.0027223790077139653 0.07295679905194075 0.015288074273086242 0.005687832259572806 0.03360091643726585 9.262374363938654e-08 7.0332776698000075 -1.035396146972519 down HLSK(ub)MQQNGYENPTYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLSKMQQNGYENPTYK 16 1 A0A0A0MRG2;E9PG40;P05067-10;P05067-3;P05067-4;P05067-5;P05067-6;P05067-7;P05067-11;P05067-8;P05067-9;P05067 A0A0A0MRG2 APP Amyloid beta A4 protein;N-APP;Soluble APP-alpha;Soluble APP-beta;C99;Beta-amyloid protein 42;Beta-amyloid protein 40;C83;P3(42);P3(40);C80;Gamma-secretase C-terminal fragment 59;Gamma-secretase C-terminal fragment 57;Gamma-secretase C-terminal fragment 50;C31 1 17334100.0 6127600.0 6901400.0 4305100.0 True False 5933082.692078668 9657165.010325547 3177465.159768396 1.0 1.6276808383640007 0.535550459124844 22.500350459760785 -6.750822516094196 1.6466067852776525 1.368709546363244 0.5332150689352139 0.6526050115634787 0.2637676777437154 0.298600384734774 1.5931021361618203 0.12652409908438067 0.3069248833203319 1.7749146902675384e-07 6.750822516094196 -0.8354944774280301 HLSK(ub)MQQNGYENPTYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLSKMQQNGYENPTYK 16 1 A0A0A0MRG2;E9PG40;P05067-10;P05067-3;P05067-4;P05067-5;P05067-6;P05067-7;P05067-11;P05067-8;P05067-9;P05067 A0A0A0MRG2 APP Amyloid beta A4 protein;N-APP;Soluble APP-alpha;Soluble APP-beta;C99;Beta-amyloid protein 42;Beta-amyloid protein 40;C83;P3(42);P3(40);C80;Gamma-secretase C-terminal fragment 59;Gamma-secretase C-terminal fragment 57;Gamma-secretase C-terminal fragment 50;C31 1 13829700.0 5787000.0 5396800.0 2645900.0 True False 7926610.287794692 5158351.531168954 2020992.9140210117 1.0 0.6507638629732722 0.25496307256746487 22.91827261728611 -7.382693355783265 0.34451113410837403 1.0557569439807046 1.3193883997021867e-15 0.9996308977875159 0.005847333230705898 0.11283292994403117 0.03065745268588072 0.015352682071005822 0.056941707216483825 4.142920926148956e-08 7.382693355783265 -1.0557569439807033 down HLSK(ub)MQQNGYENPTYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLSKMQQNGYENPTYK 16 1 A0A0A0MRG2;E9PG40;P05067-10;P05067-3;P05067-4;P05067-5;P05067-6;P05067-7;P05067-11;P05067-8;P05067-9;P05067 A0A0A0MRG2 APP Amyloid beta A4 protein;N-APP;Soluble APP-alpha;Soluble APP-beta;C99;Beta-amyloid protein 42;Beta-amyloid protein 40;C83;P3(42);P3(40);C80;Gamma-secretase C-terminal fragment 59;Gamma-secretase C-terminal fragment 57;Gamma-secretase C-terminal fragment 50;C31 1 18809200.0 6127600.0 11008000.0 1673600.0 True False 5095370.898706909 10948697.719083076 2023542.0221479053 1.0 2.148753827098555 0.3971334103787096 22.28075573519506 -6.729775569888919 1.7238259345380378 1.6915004788856232 0.39818545461804505 0.5582403424286334 0.48292096368824805 0.3367016877329932 1.959996067012221 0.2220011818837203 0.5510676854528854 1.8630496550463447e-07 6.729775569888919 -1.2933150242675782 HLSPYATLTVGDSSHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLSPYATLTVGDSSHK 16 0 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 0 25222300.0 3355100.0 7809200.0 14058000.0 False True 5089931.990665374 6415587.246441913 11279430.138159713 1.0 1.2604465557118856 2.2160276716556333 22.279214949125087 -6.946860820064383 0.5923052198658927 0.98902811919048 2.535720463853096 0.9989313485510576 0.017089802110290542 0.08477130253015287 0.04137175515039194 0.01767579914123431 0.08010976461942043 1.1301580425107898e-07 6.946860820064383 1.546692344662616 up HLSQCPSISQLK(ub)TLDLSGIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLSQCPSISQLKTLDLSGIR 20 1 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4;A0A0G2JN56;H0Y7S4;Q5TYX0;Q5VWM5;A6NGN4;O60813;O60810 A3QJZ7;O60810 LOC101929983;PRAMEF25;PRAMEF6;PRAMEF26;PRAMEF5;PRAMEF9;PRAMEF11;PRAMEF4 PRAME family member 6;Putative PRAME family member 26;PRAME family member 5;PRAME family member 9/15;PRAME family member 25;PRAME family member 11;PRAME family member 4 1 82009300.0 5381300.0 20996000.0 55632000.0 True False 8163825.52572727 17249099.757503264 44636310.81562814 1.0 2.112869720591761 5.467572852330371 22.960813919277147 -6.951342471689231 0.5439057412739026 0.9518395822877078 6.784563775986541 0.9993024686729585 0.05015098374341427 0.08295110978651052 0.0337657249548569 0.05486920762811538 0.2779961823809681 1.1185554760701564e-07 6.951342471689231 5.832724193698834 HLSQCPSISQLK(ub)TLDLSGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLSQCPSISQLKTLDLSGIR 20 1 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4;A0A0G2JN56;H0Y7S4;Q5TYX0;Q5VWM5;A6NGN4;O60813;O60810 A3QJZ7;O60810 LOC101929983;PRAMEF25;PRAMEF6;PRAMEF26;PRAMEF5;PRAMEF9;PRAMEF11;PRAMEF4 PRAME family member 6;Putative PRAME family member 26;PRAME family member 5;PRAME family member 9/15;PRAME family member 25;PRAME family member 11;PRAME family member 4 1 78969300.0 5381300.0 14946000.0 58642000.0 True False 6966198.931281485 14114241.961410092 47969757.717732176 1.0 2.0261037763407184 6.886073480090494 22.731940241369596 -6.941020616491031 0.6499985973303803 0.9462637118646121 8.236965176655966 0.9982945574388945 0.10602071924463852 0.08730407268897579 0.05251221987156602 0.10401953769466483 0.41644274660459246 1.145458563833743e-07 6.941020616491031 7.290701464791354 HLSSLQLFYGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLSSLQLFYGK 11 0 Q9BWG6-3;Q9BWG6-2;Q9BWG6 Q9BWG6-3 SCNM1 Sodium channel modifier 1 0 8839900.0 2671500.0 2966600.0 3201800.0 False True 3502362.3708428033 2523994.84371623 2870508.4498343077 1.0 0.720654968408897 0.8195920769739062 21.739896928815735 -10.926008710932402 10.843601142089868 1.0362378569616246 0.7701235226914129 0.8780184184249982 0.040390905435102646 0.022546603659707804 0.00015384648148699499 0.024918893898030016 0.013036108674032595 1.1857449646556219e-11 10.926008710932402 -0.2661143342702117 HLSVNDLPVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLSVNDLPVGR 11 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 16712800.0 3402800.0 6730400.0 6579600.0 False True 4461103.752762073 5726250.554893716 5898806.107979837 1.0 1.2835950186875464 1.322275032121281 22.08896927086644 -12.577413455298874 0.30377538348593447 7.299381095289277e-08 1.3319074948775596 0.9995601133191095 0.0030133660773799887 7.2894088765154725 0.17003745217841315 4.523452209256541 0.013755029219861272 2.645979923910781e-13 12.577413455298874 1.3319074218837486 HLSVNDLPVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLSVNDLPVGR 11 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 10992900.0 0.0 4501100.0 6491800.0 False True 0.0 6298412.702926412 4791402.830174555 0.0 HLSVNDLPVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLSVNDLPVGR 11 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 18858600.0 3402800.0 7940600.0 7515200.0 False True 4660907.117212333 7589758.035947264 5740264.5404024115 1.0 1.6283864589188948 1.2315766858352752 22.15217933238933 -10.07773951646937 4.240938365279308 0.9999514641536722 1.429981572071356 0.6102237320737901 0.1619969117899145 20791121.65273423 12351486.573430358 9325.561371831282 0.05545585273188954 8.361043511318985e-11 10.07773951646937 0.4300301079176838 HLSVNDLPVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLSVNDLPVGR 11 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 6975900.0 0.0 3844400.0 3131500.0 False True 0.0 3823689.454146345 3786282.1715799207 0.0 HLSVNDLPVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLSVNDLPVGR 11 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 22087500.0 9780500.0 12307000.0 0.0 False True 12661050.052477757 11622104.63127753 0.0 1.0 0.917941606984098 0.0 23.593893724797756 -7.097273567216083 0.9933341400366668 1.001257943839069 7.988887501070643e-18 0.9894045998491604 0.04666024590543627 0.08462583666615006 0.15893712434892104 0.03839916142069215 0.0678908354879951 7.993305886261566e-08 7.097273567216083 -1.001257943839069 down HLTDAYFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLTDAYFK 8 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 39554300.0 9165400.0 21189000.0 9199900.0 False True 12015928.157859866 18027683.794075098 8247982.599672261 1.0 1.500315544270529 0.6864207651139363 23.518444756459886 -6.740395878328277 1.685435756537741 1.2975487289627352 0.6859187807778532 0.6066667003850938 0.21020846810079902 0.31708603015825026 1.7688042069087386 0.09866444524810025 0.24199086012808432 1.8180428778280793e-07 6.740395878328277 -0.611629948184882 HLTDAYFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLTDAYFK 8 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 21836700.0 9047000.0 4303200.0 8486500.0 False True 8759807.937077424 6021490.200891551 6263631.060457244 1.0 0.6873997973636542 0.7150420540552409 23.06246780772784 -10.055233828977892 5.111401040251201 1.0000044286490082 0.7012209257083523 0.9936213477281224 0.011284904042715583 5.695281673295181e-07 1.0526458747763585e-07 0.010926723247672288 0.0036421871178682606 8.805746341777626e-11 10.055233828977892 -0.2987835029406559 HLTDAYFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLTDAYFK 8 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 119677000.0 28828000.0 74326000.0 16523000.0 False True 43734183.60910296 61061944.588311434 13257221.807711834 1.0 1.396206343625489 0.30313180020016284 25.382258027343912 -6.808639209274586 1.4202423227042362 1.2162780820280115 0.2845970016161432 0.8562479453664429 0.17131271838572928 0.2086605590231592 0.829784308097409 0.09485289817544189 0.2195530010912994 1.553677193392772e-07 6.808639209274586 -0.9316810804118683 down HLTDAYFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLTDAYFK 8 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 30291900.0 9165400.0 11740000.0 9386500.0 False True 12554096.065621832 11221287.981011616 7169602.021035652 1.0 0.8938348027891884 0.5710966351985236 23.581654817982777 -6.951152713763384 0.5460414736963072 1.0045717249385842 0.4453005045434822 0.9992886697003581 0.004864431190552128 0.08302613479647254 0.03407201281164468 0.005307007913660011 0.026754481925512788 1.1190443175206533e-07 6.951152713763384 -0.559271220395102 HLTDAYFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLTDAYFK 8 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 21278500.0 9047000.0 8813900.0 3417600.0 False True 7522981.350055705 8766417.77127784 4132204.3588029835 1.0 1.1652850596542987 0.5492774960517994 22.842873083162118 -6.83528139167351 1.304051015594047 1.088049344435344 0.5308274730229441 0.9160498751184755 0.07542777244662963 0.17437908026491308 0.5780446102703511 0.04538641870586952 0.10447047244514138 1.461230095378456e-07 6.83528139167351 -0.5572218714124 HLTDAYFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLTDAYFK 8 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 68716000.0 28828000.0 18195000.0 21693000.0 False True 37318414.28483501 17182432.25530954 17745096.588976573 1.0 0.4604277160375467 0.47550510730536594 25.15338434943636 -9.984085004827236 6.252199037453338 1.0000002367207355 0.46796641169951125 0.9993980305614137 0.006155319209827495 2.0316296886033474e-08 3.2954286091423095e-09 0.005959864861720972 0.00198662073250847 1.037325359374187e-10 9.984085004827236 -0.5320338250212242 HLTGEFEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLTGEFEK 8 0 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 30134000.0 5129000.0 14844000.0 10161000.0 False True 6724168.669306651 12629333.061458815 9109637.191194456 1.0 1.878199920699054 1.354760363578711 22.680924482970276 -10.398576271124535 5.19623411072848 0.9995378525139377 1.6164801421389074 0.6490557341039151 0.21369330435562828 0.0011449168651274818 0.00013251495189785747 0.20705635302032616 0.06896921741376931 3.994144096884861e-11 10.398576271124535 0.6169422896249698 HLTGEFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLTGEFEK 8 0 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 20828700.0 6276500.0 3643200.0 10909000.0 False True 6077255.943082395 5097948.759037017 8051605.63701503 1.0 0.8388570115826532 1.324875192426278 22.534988621457302 -6.817335597767941 1.3832050272080778 0.912898015846449 1.3349026205006536 0.8781501928679193 0.07055901740079121 0.19698836914048884 0.7412504416117535 0.04009101014111474 0.09248246492778643 1.522875508499885e-07 6.817335597767941 0.42200460465420453 HLTGEFEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLTGEFEK 8 0 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 61690400.0 7635600.0 47778000.0 6276800.0 False True 11583763.437132878 39251642.60878218 5036187.728780833 1.0 3.388505197106946 0.43476265344273557 23.465600709421388 -6.691534543713302 1.860847275525625 2.4952552473617247 0.44473368589306705 0.37770807550692964 1.0098521241816765 0.4133561192335187 2.7762870073257555 0.43393766400194544 1.1278712340687889 2.034536362719149e-07 6.691534543713302 -2.0505215614686576 HLTGEFEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLTGEFEK 8 0 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 30992000.0 5129000.0 12431000.0 13432000.0 False True 7025329.9060133 11881757.316180201 10259638.24072348 1.0 1.6912739295004586 1.4603781428031997 22.744134544493168 -10.152947959783749 4.84117606384618 0.9999543381407381 1.5758260361543994 0.8923871808298042 0.09426281020334547 4.6461347689182974e-05 8.129100016563456e-06 0.09127678642984897 0.03042319117242503 7.031565719968515e-11 10.152947959783749 0.5758716980136613 HLTGEFEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLTGEFEK 8 0 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 13415900.0 6276500.0 4735800.0 2403600.0 False True 5219187.846095348 4710287.305417297 2906181.6470092623 1.0 0.9024943045384396 0.5568264129798424 22.315393896891578 -6.947650210769344 0.5840710765459856 1.0040719765844184 0.4380314522841996 0.9990037486219149 0.006001633037550307 0.08444323726384956 0.039974706614653764 0.006260788362116336 0.02890834414721801 1.128105688656182e-07 6.947650210769344 -0.5660405243002188 HLTGEFEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLTGEFEK 8 0 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 21362700.0 7635600.0 6666300.0 7060800.0 False True 9884434.720177822 6295314.544851334 5775806.849926049 1.0 0.6368917113692143 0.584333552037677 23.236727031513837 -13.999999999999998 0.27221735620110227 3.8362690895587757 0.5672590879771244 0.9995881144378993 0.003750683202687318 14.992875361981167 0.1651831873521005 23.56433240855419 0.02158923965054322 1.0000000000000041e-14 13.999999999999998 -3.269010001581651 HLTIVSLASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLTIVSLASR 10 0 J3KQ34;Q9H9Q2;J3KQ41;Q9H9Q2-3 J3KQ34 COPS7B COP9 signalosome complex subunit 7b 0 16221500.0 5404800.0 7273100.0 3543600.0 False True 7085745.140157647 6187981.830321757 3176942.264611422 1.0 0.8733000845954902 0.44835683499346685 22.75648814490698 -6.9489208228196135 0.5705731989897829 1.0052798968062278 0.29569642270920815 0.9991138137795972 0.007023181156108557 0.08392210539180107 0.037779007179623805 0.007435774882252393 0.035411077254831703 1.124810021859332e-07 6.9489208228196135 -0.7095834740970196 down HLTIVSLASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLTIVSLASR 10 0 J3KQ34;Q9H9Q2;J3KQ41;Q9H9Q2-3 J3KQ34 COPS7B COP9 signalosome complex subunit 7b 0 10091800.0 4562500.0 2730100.0 2799200.0 False True 4417665.93488623 3820243.167283422 2066005.545800024 1.0 0.8647650645366887 0.46766903071706134 22.074852895146094 -6.951932389324059 0.5372170038879422 1.0059557200053288 0.3082278937914989 0.9993442956589472 0.005785014116622844 0.08271907636980132 0.03282279922704051 0.0063874592777058235 0.03287092821548003 1.1170371338426387e-07 6.951932389324059 -0.69772782621383 down HLTIVSLASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLTIVSLASR 10 0 J3KQ34;Q9H9Q2;J3KQ41;Q9H9Q2-3 J3KQ34 COPS7B COP9 signalosome complex subunit 7b 0 16805900.0 5404800.0 4435700.0 6965400.0 False True 7403100.61922805 4239716.1071016425 5320315.976915975 1.0 0.5726946485219776 0.7186604978861877 22.819698206429873 -10.27069084888649 5.100317263720316 1.0000675601473037 0.6456775732039736 0.8870895900602012 0.059590308469423973 4.5787586800514396e-05 6.547280958382902e-06 0.05770903234762612 0.019232689358065692 5.361781984034248e-11 10.27069084888649 -0.3543899869433301 HLTSLNLVQNNFSPK(ub)GMMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLTSLNLVQNNFSPKGMMK 19 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 19114300.0 3248400.0 12001400.0 3864500.0 True False 4258683.857550349 10210837.901090791 3464638.6109015807 1.0 2.3976510684134698 0.8135467968017909 22.021976205041717 -6.673744916961738 1.9238134592500569 1.8892013367284237 0.8197893881670424 0.29589727555864276 0.5931795759966971 0.4525545225892161 3.2324944423544664 0.2478984280043279 0.6591734801636594 2.1196057209797388e-07 6.673744916961738 -1.0694119485613813 HLTSLNLVQNNFSPK(ub)GMMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 HLTSLNLVQNNFSPKGMMK 19 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 44754800.0 14186200.0 11791100.0 18777500.0 True False 13735866.846133277 16499347.71977421 13859109.437074859 1.0 1.2011872206244392 1.0089723198631817 23.711444623417112 -11.055273354563266 2.550829425306924 0.8546179257286157 1.1050797698979475 0.28493618138824683 0.07847140628257837 28879329.457750812 13647553.085790122 24416093.776793975 0.028717596003555376 8.804944958256776e-12 11.055273354563266 0.2504618441693318 HLTSLNLVQNNFSPK(ub)GMMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLTSLNLVQNNFSPKGMMK 19 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 61666400.0 10545000.0 19602400.0 31519000.0 True False 15997535.942763655 16104198.565749748 25289255.834731527 1.0 1.006667440746357 1.580821941904803 23.931346372016936 -6.909436471401577 0.899566328902335 0.9819044977657849 1.6541336334848176 0.99070705194523 0.02624432012313865 0.10479194631696345 0.14079847932940595 0.02142685696755685 0.058919230128910136 1.2318661699452678e-07 6.909436471401577 0.6722291357190326 HLTSLNLVQNNFSPK(ub)GMMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLTSLNLVQNNFSPKGMMK 19 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 25798500.0 3248400.0 13139100.0 9411000.0 True False 4449421.264709226 12558571.11680662 7188315.625629001 1.0 2.8225178893298914 1.6155619344572816 22.08518626656461 -10.45856959178041 4.930557080263099 0.9973910581942949 2.219039911893695 0.5763008923127104 0.49273770524229893 0.014148846341886805 0.0015537011219885586 0.47768827042436596 0.15903041053760314 3.478807584232806e-11 10.45856959178041 1.2216488536994003 HLTSLNLVQNNFSPK(ub)GMMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLTSLNLVQNNFSPKGMMK 19 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 40809400.0 12034700.0 13438400.0 15336300.0 True False 10007386.277607532 13366004.671886457 18543049.4229606 1.0 1.335613945650739 1.8529363120970377 23.254561885466455 -6.964800813202013 0.3614588433196264 0.9561586783855522 2.250159748230214 0.9999089749040267 0.0033471980849514673 0.07802866381870091 0.015098972582614792 0.006920527080413802 0.04414757396887283 1.0844241652168919e-07 6.964800813202013 1.2940010698446616 HLTYENVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLTYENVER 9 0 H3BSC1;P62491;H3BMH2;P62491-2;Q15907-2;Q15907 H3BSC1 RAB11A;RAB11B Ras-related protein Rab-11A;Ras-related protein Rab-11B 0 7374000.0 1492400.0 3195400.0 2686200.0 False True 1956550.8524221594 2718658.775571646 2408257.7918498693 1.0 1.3895160313395467 1.230869000347478 20.899881176922378 -10.238889381560652 5.417155866275271 0.9999766344255075 1.3101925158435392 0.8359921189848627 0.06476737918977371 1.827841219820732e-05 2.56823139007731e-06 0.06271546389810495 0.020903581748277573 5.7691338934853776e-11 10.238889381560652 0.3102158814180317 HLTYENVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLTYENVER 9 0 H3BSC1;P62491;H3BMH2;P62491-2;Q15907-2;Q15907 H3BSC1 RAB11A;RAB11B Ras-related protein Rab-11A;Ras-related protein Rab-11B 0 5445500.0 1439800.0 1029400.0 2976300.0 False True 1394094.3371066756 1440444.7882500847 2196717.742913908 1.0 1.0332477149570851 1.5757310566751235 20.41089675970626 -6.919429243315009 0.8289311720583489 0.9877833144898809 1.662078477848318 0.9940214885900962 0.02040612213417986 0.09850814203048082 0.10735632798228192 0.017529206296137384 0.05222659786560282 1.203845508283207e-07 6.919429243315009 0.6742951633584371 HLTYENVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLTYENVER 9 0 H3BSC1;P62491;H3BMH2;P62491-2;Q15907-2;Q15907 H3BSC1 RAB11A;RAB11B Ras-related protein Rab-11A;Ras-related protein Rab-11B 0 14738000.0 2384900.0 10123000.0 2230100.0 False True 3618067.6595445275 8316471.558640001 1789319.7575124486 1.0 2.2985948139198005 0.4945512151471769 21.78678795660247 -6.713510582747845 1.7823326970889133 1.7954503401345485 0.4982683338299476 0.48191287767569746 0.5469296179344966 0.36806734080855724 2.281256924110196 0.24398288845798796 0.6172899775372503 1.934146727381485e-07 6.713510582747845 -1.297182006304601 HLTYENVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLTYENVER 9 0 H3BSC1;P62491;H3BMH2;P62491-2;Q15907-2;Q15907 H3BSC1 RAB11A;RAB11B Ras-related protein Rab-11A;Ras-related protein Rab-11B 0 6431200.0 1492400.0 2020200.0 2918600.0 False True 2044180.6105935385 1930940.8840919659 2229286.7904538107 1.0 0.9446038545152363 1.0905527519931448 20.96309123844527 -6.8038620011082385 1.4401450011989962 0.9695831851635046 1.0927634783956783 0.84318997227715 0.02382165658060726 0.21529842688199866 0.8811262112677497 0.013010593189207213 0.030188801566448827 1.5708618729824292e-07 6.8038620011082385 0.12318029323217372 HLTYENVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLTYENVER 9 0 H3BSC1;P62491;H3BMH2;P62491-2;Q15907-2;Q15907 H3BSC1 RAB11A;RAB11B Ras-related protein Rab-11A;Ras-related protein Rab-11B 0 7240400.0 2384900.0 1668300.0 3187200.0 False True 3087300.063407209 1575457.6384464388 2607162.3034336474 1.0 0.5103027260355545 0.8444797233464663 21.55791427869492 -10.058428794175159 5.649767313141113 1.0000015453183257 0.6773912246909246 0.5540927783715125 0.13642718786483565 2.6555870906407554e-06 4.424701758065087e-07 0.13209569040488173 0.044031685547489985 8.741202993956335e-11 10.058428794175159 -0.32261032062740114 HLVCSSGGNAGIAAAYAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLVCSSGGNAGIAAAYAAR 19 0 Q96GA7;F8VYZ3 Q96GA7 SDSL Serine dehydratase-like 0 4649700.0 1186800.0 1646300.0 1816600.0 False True 1555906.2929875504 1400678.4572271393 1628635.6580576578 1.0 0.9002331718433039 1.0467440522593794 20.569323743585866 -6.7233911467263505 1.7473709871577743 0.9395221196303024 1.0465560187597254 0.528322178045787 0.041965855776154776 0.3487864890675705 2.0830720280498753 0.019057301389427204 0.04764653612530073 1.8906400492477484e-07 6.7233911467263505 0.10703389912942296 HLVFPLLEFLSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLVFPLLEFLSVK 13 0 P60228;H0YBR5;E5RHS5;H0YBP5;E5RII3;E5RIP5;E5RJ25 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 312899000.0 128750000.0 91328000.0 92821000.0 False True 124662901.724187 127795746.66922839 68508395.52968848 1.0 1.0251305312303152 0.549549180888323 26.89345695833666 -6.894427494907349 0.9958057418161841 1.022907909848989 0.5049097893050503 0.983584690710438 0.027995845043166198 0.11562495018698676 0.2014437101303549 0.02128649381949201 0.05398812369613288 1.2751829728814257e-07 6.894427494907349 -0.5179981205439388 HLVFPLLEFLSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLVFPLLEFLSVK 13 0 P60228;H0YBR5;E5RHS5;H0YBP5;E5RII3;E5RIP5;E5RJ25 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 2536397900.0 973327900.0 776660000.0 786410000.0 False True 1476609584.100965 638058954.9277229 630975718.8042521 1.0 0.43211080423550524 0.42731384490398133 30.459641281621316 HLVFPLLEFLSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLVFPLLEFLSVK 13 0 P60228;H0YBR5;E5RHS5;H0YBP5;E5RII3;E5RIP5;E5RJ25 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 457660000.0 128750000.0 122640000.0 206270000.0 False True 107061329.59209387 121979313.9778659 249400103.31527725 1.0 1.1393405484745043 2.329506874849186 26.673862233770937 -6.9288979862201465 0.7557818881026375 0.9811424897904066 2.5671247212798636 0.9963172765525954 0.03620559351051073 0.09321378710107535 0.08051255470340662 0.03277154234422543 0.1083491428787976 1.1778826202475792e-07 6.9288979862201465 1.585982231489457 up HLVFPLLEFLSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLVFPLLEFLSVK 13 0 P60228;H0YBR5;E5RHS5;H0YBP5;E5RII3;E5RIP5;E5RJ25 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 2465047900.0 973327900.0 963500000.0 528220000.0 False True 1259992153.7112696 909880378.0154308 432089379.9948923 1.0 0.722131781007846 0.3429302148606131 30.230767603713765 -6.966780708982477 0.3260476385325444 1.048380502274925 0.004340686580167921 0.9999452857884297 0.0019920437084589167 0.07736177646394035 0.012756519733646486 0.005613783036625457 0.03318232010447897 1.0794916590855402e-07 6.966780708982477 -1.0440398156947572 down HLVGVCYTEDEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLVGVCYTEDEAK 13 0 P08574 P08574 CYC1 Cytochrome c1, heme protein, mitochondrial 0 3599240.0 1508300.0 645440.0 1445500.0 False True 2065959.2702748822 616922.3266153444 1104102.6710069817 1.0 0.29861301502486104 0.5344261558748337 20.97838038153699 -10.178155820654055 5.32229032831296 1.0000246565867104 0.41651958544997264 0.8908666680406457 0.09627031162152386 2.816720990931677e-05 4.349522211191743e-06 0.09321725894189518 0.03107110947027551 6.635049685333386e-11 10.178155820654055 -0.5835050711367378 HLVLAGGSKPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLVLAGGSKPR 11 1 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 13292740.0 2756200.0 4959740.0 5576800.0 False True 3613404.8910787725 4219766.1249151 4999766.232442992 1.0 1.1678088263325783 1.3836717398559575 21.78492749074921 -6.967684704893056 0.30852152097076113 0.9661585379645223 1.592169000418994 0.9999582725854587 0.0010144260627196493 0.07706139080721312 0.011705647568303966 0.0034384485338127355 0.019192166073122456 1.0772470044683117e-07 6.967684704893056 0.6260104624544716 HLVLAGGSKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLVLAGGSKPR 11 1 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 6859800.0 2146400.0 1645900.0 3067500.0 False True 2078263.706879958 2303116.45325511 2264029.726972555 1.0 1.108192596363393 1.0893852014437004 20.98694729597715 -10.176400524036529 4.676700032437542 0.9999861011042951 1.0987888989043275 0.9735360572162093 0.007678086826718185 1.1128526236387962e-06 1.959744501238122e-07 0.00743532134205059 0.002478091867172773 6.661920963698054e-11 10.176400524036529 0.09880279780003243 HLVLAGGSKPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLVLAGGSKPR 11 1 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 7538060.0 1653400.0 3213700.0 2670960.0 False True 2508328.6797311953 2640190.126247296 2143043.585276643 1.0 1.0525694449780927 0.8543711207361795 21.258294973903283 -6.83617443841329 1.300112149653379 1.0279934945724498 0.8483334158784495 0.9176614062339588 0.024056037136078866 0.17331615144354645 0.5707233443573545 0.014517588399941607 0.033417952451574605 1.45822843163483e-07 6.83617443841329 -0.17966007869400036 HLVLAGGSKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLVLAGGSKPR 11 1 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 9460600.0 2756200.0 2662300.0 4042100.0 False True 3775241.6235043653 2544670.78295121 3087439.229662627 1.0 0.6740418327421177 0.8178123515169113 21.848137552272103 -10.012175377436803 4.549615708920354 1.0000077716064188 0.7459270921163741 0.8063534799306208 0.058694068581957935 17554478.630561695 12877169.321124839 1258.8208084027895 0.020092540992964848 9.723544868646719e-11 10.012175377436803 -0.25408067949004476 HLVLAGGSKPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLVLAGGSKPR 11 1 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 5228000.0 2146400.0 1981200.0 1100400.0 False True 1784826.701642485 1970526.8823625909 1330488.5523252604 1.0 1.1040438158781551 0.7454441101205397 20.767352571411426 -6.82907298047945 1.3319558226931874 1.0556327984153713 0.7359701401097157 0.9040174094814791 0.046668250819108 0.1819640250530273 0.6316710472676471 0.02751176236056519 0.06331800161878977 1.4822689781576623e-07 6.82907298047945 -0.31966265830565554 HLVLAGGSKPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLVLAGGSKPR 11 1 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 6526680.0 1653400.0 1813180.0 3060100.0 False True 2140358.8933865083 1712274.9390866812 2503193.199277517 1.0 0.7999943114107811 1.1695203112955168 21.029421295995732 -6.75971595793468 1.6136169478600688 0.8837842586160166 1.1708478643396123 0.6897814236132933 0.0841192425165318 0.283392837841284 1.4542539892714479 0.04113358750443968 0.09887516443335972 1.738937776166239e-07 6.75971595793468 0.2870636057235957 HLVLPIALNK(ub)EGDEVGTGITDDNEDENSANQIAGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLVLPIALNKEGDEVGTGITDDNEDENSANQIAGK 35 1 B4DVT3;B4DJL6;Q96SY0-4;Q96SY0-3;Q96SY0 B4DVT3 VWA9 von Willebrand factor A domain-containing protein 9 1 42408200.0 9152200.0 16122000.0 17134000.0 True False 13884556.515444443 13244903.138239076 13747457.38990102 1.0 0.9539305863681098 0.9901257828875614 23.726977761196384 -10.188833906269082 5.035917172631825 1.0000023001454539 0.9720281846278386 0.44330090262747124 0.014776627102178043 3.8164325007984943e-07 6.145977262014557e-08 0.014308584179865863 0.004769135889972205 6.473901595060757e-11 10.188833906269082 -0.027974115517615306 HLVLPIALNK(ub)EGDEVGTGITDDNEDENSANQIAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLVLPIALNKEGDEVGTGITDDNEDENSANQIAGK 35 1 B4DVT3;B4DJL6;Q96SY0-4;Q96SY0-3;Q96SY0 B4DVT3 VWA9 von Willebrand factor A domain-containing protein 9 1 38860200.0 9152200.0 12179000.0 17529000.0 True False 11847703.31683319 11501227.943798566 14338901.862728562 1.0 0.9707559040120162 1.210268478140897 23.498104083288833 -6.876354564774887 1.099877125131225 0.9826160472800616 1.2261025853051728 0.9706264278746456 0.018284363963354935 0.1309106871792706 0.2921874152662906 0.012844627998135995 0.03079478166601172 1.329368657558684e-07 6.876354564774887 0.24348653802511122 HLVQITIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLVQITIK 8 0 Q9H2K0 Q9H2K0 MTIF3 Translation initiation factor IF-3, mitochondrial 0 3210970.0 1246300.0 1086900.0 877770.0 False True 1206736.8886901285 1520904.838108623 647855.7044644499 1.0 1.2603450282849256 0.5368657497225224 20.20267972117444 -6.809387292719639 1.4172626655025922 1.1419859174135145 0.5244021948945705 0.8581920400180132 0.11267158917670744 0.20763177829976132 0.8221220409049855 0.06251538619534772 0.1446410567932705 1.5510032479906485e-07 6.809387292719639 -0.617583722518944 HLVQITIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLVQITIK 8 0 Q9H2K0 Q9H2K0 MTIF3 Translation initiation factor IF-3, mitochondrial 0 10680600.0 3651600.0 3583300.0 3445700.0 False True 5539744.167718896 2943832.1185493153 2764655.8846960366 1.0 0.5314021784080869 0.499058404322386 22.40138792168427 -13.999999999999998 0.3796754800083231 7.938163937149996 0.4962006496012537 0.9998069956261538 0.0031800639246072956 23.994047154802097 0.20091534264705285 136.05152152786076 0.008775088880182535 1.0000000000000041e-14 13.999999999999998 -7.4419632875487425 HLVQITIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLVQITIK 8 0 Q9H2K0 Q9H2K0 MTIF3 Translation initiation factor IF-3, mitochondrial 0 6394700.0 1098700.0 2040000.0 3256000.0 False True 1504919.081251085 1949866.0546221205 2486999.8594249305 1.0 1.2956617262113106 1.6525804545965435 20.52125448540133 -6.968614856558397 0.2893674937884481 0.9297307897498808 2.029528929956194 0.9999694700511991 0.001474195216782461 0.07675480625531694 0.010630957681545261 0.006256832311276076 0.03239074299084935 1.0749422760391238e-07 6.968614856558397 1.099798140206313 HLVQITIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLVQITIK 8 0 Q9H2K0 Q9H2K0 MTIF3 Translation initiation factor IF-3, mitochondrial 0 13602100.0 3651600.0 5243300.0 4707200.0 False True 4727068.183797125 4951505.745768871 3850537.899950704 1.0 1.0474792309408707 0.8145721090186755 22.17251424377672 -6.853606609031371 1.2175262391149257 1.0254380902117952 0.8045912350325493 0.9453947777433664 0.02348217727582189 0.1535344651416423 0.4361545596029122 0.015076527065290533 0.03497887537953738 1.400855665771016e-07 6.853606609031371 -0.22084685517924596 HLVQTHYYNYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLVQTHYYNYR 11 0 O75818-2;O75818;A0A087X1N3;F8WC38 O75818-2 RPP40 Ribonuclease P protein subunit p40 0 8348200.0 2662500.0 3698000.0 1987700.0 False True 3490563.2836866807 3146272.8146911035 1782031.8713647514 1.0 0.901365355384148 0.5105284524400875 21.735028436993524 -6.945091285657776 0.6103625394633453 1.0043208690223164 0.3872067155979651 0.9987575691151019 0.007450110131134171 0.08551879708721262 0.04459601809876046 0.007570268262135907 0.032960577463908645 1.1347722694210926e-07 6.945091285657776 -0.6171141534243514 HLVQTHYYNYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLVQTHYYNYR 11 0 O75818-2;O75818;A0A087X1N3;F8WC38 O75818-2 RPP40 Ribonuclease P protein subunit p40 0 7759200.0 2662500.0 2194200.0 2902500.0 False True 3646898.201357075 2097252.9887509104 2216989.2788639013 1.0 0.5750785662101798 0.6079109304556186 21.798238498516415 -10.08143123583945 5.39158147594229 1.0000045567916427 0.5914947483326143 0.9951786194973832 0.01340375657608706 7.341772792807719e-07 1.2509501964087798e-07 0.012978276305357863 0.004326043832838989 8.290271701731774e-11 10.08143123583945 -0.4085098084590284 HLVQTHYYNYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLVQTHYYNYR 11 0 O75818-2;O75818;A0A087X1N3;F8WC38 O75818-2 RPP40 Ribonuclease P protein subunit p40 0 13627500.0 3853000.0 3854100.0 5920400.0 False True 4987784.453984643 3639615.9469738174 4842947.948433915 1.0 0.7297059406940088 0.9709617552869548 22.249967690087882 -10.289653027147358 7.363187876795766 1.0000008804513176 0.8503338481691655 0.33911976674893163 0.09849227387203689 1.4235958028383708e-06 1.373162848792828e-07 0.0953652946930226 0.03178824470304156 5.132712903764476e-11 10.289653027147358 -0.14966703228215217 HLVVNIGTHCYLALAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLVVNIGTHCYLALAK 16 0 Q69YN2-3;Q69YN2;Q69YN2-2 Q69YN2-3 CWF19L1 CWF19-like protein 1 0 47273000.0 8880000.0 23828000.0 14565000.0 False True 13471609.214958869 19575707.230986234 11686221.365933722 1.0 1.4531083049268811 0.8674703355377431 23.68341885857335 -6.700075957715929 1.8301858479532078 1.2813277184618834 0.8691837736256742 0.4181832184597738 0.1912581150174718 0.3953339410908776 2.574397457435153 0.08336047982017945 0.214393920740446 1.994913375892413e-07 6.700075957715929 -0.4121439448362092 HLVVNIGTHCYLALAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLVVNIGTHCYLALAK 16 0 Q69YN2-3;Q69YN2;Q69YN2-2 Q69YN2-3 CWF19L1 CWF19-like protein 1 0 32549000.0 8880000.0 13032000.0 10637000.0 False True 11495335.050969021 12306757.743951317 8701175.144836767 1.0 1.0705871285512374 0.756930972977885 23.4545451806658 -6.847592712292874 1.2465889513621329 1.0376052111011038 0.7449583708714147 0.9367367124376349 0.033791553988523806 0.16012556614872697 0.4800417779860712 0.021223474202013617 0.04904462502939994 1.4203889587784015e-07 6.847592712292874 -0.2926468402296891 HLVYESDQNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLVYESDQNK 10 0 O43852;O43852-3;O43852-5;O43852-9;O43852-15;H0Y875;O43852-2;O43852-4 O43852;O43852-2 CALU Calumenin 0 6900500.0 2391900.0 2041300.0 2467300.0 False True 2315970.443759864 2856401.7352388753 1821040.1125865956 1.0 1.233349822289462 0.7862967843537012 21.1431854112035 -6.76483752837257 1.5939746769929 1.1347227223807703 0.7842442978856792 0.7105103043643828 0.09822900141472761 0.274863244465885 1.3773350225208387 0.04859628096485373 0.11624703521877207 1.718551185070124e-07 6.76483752837257 -0.35047842449509115 HLVYESDQNKDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLVYESDQNKDGK 13 1 O43852;O43852-3;O43852-5;O43852-9;O43852-15;H0Y875;O43852-2;O43852-4 O43852;O43852-2 CALU Calumenin 0 12168200.0 1690300.0 5602400.0 4875500.0 False True 2215999.6688884846 4766543.757984162 4371030.029098368 1.0 2.150967721206834 1.9724867699510162 21.079526235145853 -10.161687320307486 4.5293128664179 0.9998305537204377 2.061727245599542 0.9792455750704554 0.07286454330070495 0.00012469562702797118 2.3079266584237396e-05 0.07056182184065195 0.023516930217855586 6.891482849665726e-11 10.161687320307486 1.0618966918791042 HLVYESDQNKDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLVYESDQNKDGK 13 1 O43852;O43852-3;O43852-5;O43852-9;O43852-15;H0Y875;O43852-2;O43852-4 O43852;O43852-2 CALU Calumenin 0 6431800.0 2248000.0 1195900.0 2987900.0 False True 2176638.4704929884 1673429.1065361134 2205279.354921369 1.0 0.7688135302309057 1.0131583103104365 21.053670371824918 -11.065526175424772 11.326993827602736 1.6021395830589231 0.8909859202706708 0.20973485773550982 0.099753338751237 0.04151816929296716 0.0002401811982316881 0.0026436947274691425 0.03219525164267733 8.599512350831288e-12 11.065526175424772 -0.7111536627882523 HLVYESDQNKDGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLVYESDQNKDGK 13 1 O43852;O43852-3;O43852-5;O43852-9;O43852-15;H0Y875;O43852-2;O43852-4 O43852;O43852-2 CALU Calumenin 0 15728300.0 2264400.0 9840300.0 3623600.0 False True 3435260.349814518 8084221.582385186 2907393.8717196966 1.0 2.353306812050412 0.8463387271001679 21.711988010770124 -6.670120246650325 1.9380701558691573 1.863765994669477 0.8525674972022512 0.27919684374906584 0.5748465158051016 0.46077638419815437 3.3371386752266634 0.2388402672239291 0.6377602228435906 2.1373702164679703e-07 6.670120246650325 -1.0111984974672257 HLVYESDQNKDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLVYESDQNKDGK 13 1 O43852;O43852-3;O43852-5;O43852-9;O43852-15;H0Y875;O43852-2;O43852-4 O43852;O43852-2 CALU Calumenin 0 11968000.0 1690300.0 5232700.0 5045000.0 False True 2315249.5886399467 5001502.011775082 3853474.9050364774 1.0 2.160243127270407 1.664388549702814 21.142736296668744 -10.42371233530468 5.45852058989324 0.9993476703787157 1.912315838486616 0.818629421801036 0.20243178361067277 0.0016080645411800957 0.0001697725858532591 0.19613055272869334 0.06533457722226342 3.769533998533495e-11 10.42371233530468 0.9129681681079002 HLVYESDQNKDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLVYESDQNKDGK 13 1 O43852;O43852-3;O43852-5;O43852-9;O43852-15;H0Y875;O43852-2;O43852-4 O43852;O43852-2 CALU Calumenin 0 4580910.0 2248000.0 1560000.0 772910.0 False True 1869311.6032856458 1551595.9703642458 934521.9074679357 1.0 0.8300360237624597 0.4999283724689603 20.834075647259194 -6.960614517338358 0.42669058766329865 1.0135820500028259 0.3037922784339057 0.9997923014161982 0.0029920692316850726 0.07948240559579317 0.02032610026786995 0.004291615971304714 0.02743085070293354 1.0949278002579069e-07 6.960614517338358 -0.7097897715689201 down HLVYESDQNKDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLVYESDQNKDGK 13 1 O43852;O43852-3;O43852-5;O43852-9;O43852-15;H0Y875;O43852-2;O43852-4 O43852;O43852-2 CALU Calumenin 0 6577200.0 2264400.0 1505100.0 2807700.0 False True 2931310.4379971055 1421339.8619107662 2296727.40943482 1.0 0.48488206622084484 0.7835155839052377 21.483114332862574 -10.235634527813074 5.716508811142551 1.0000156222340257 0.6341988250630374 0.6667290035252103 0.12191662306988797 2.4274925908987768e-05 3.245665962468736e-06 0.11805029908838229 0.03934842089795666 5.812533543705856e-11 10.235634527813074 -0.36581679717098836 HLWDYTFGPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLWDYTFGPEK 11 0 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 0 16641200.0 2829400.0 6719300.0 7092500.0 False True 3709370.7999485773 5716806.631626261 6358636.136064043 1.0 1.541179606984967 1.7142088184206854 21.822743060542937 -11.377999454303982 0.20727999043133036 3.8671993696098126e-10 1.8364805941839217 0.999361432135549 0.007687424343058911 3.8015015656171465 0.12024596736648219 1.8336635814807427 0.10322154344344707 4.187940913371865e-12 11.377999454303982 1.8364805937972017 HLWDYTFGPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLWDYTFGPEK 11 0 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 0 11125700.0 2899100.0 2545000.0 5681600.0 False True 2807069.6573871104 3561231.7719996744 4193418.5156535567 1.0 1.268665265440743 1.4938776117002006 21.420633434072386 -6.973159870279626 0.16618479928262214 0.7904951328068424 1.9780573478656258 0.9999977062096841 0.0003057051308509063 0.0752900489343678 0.005162783636496245 0.00983233812332946 0.02643417714092181 1.0637513633908594e-07 6.973159870279626 1.1875622150587835 HLWDYTFGPEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLWDYTFGPEK 11 0 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 0 37608700.0 9002500.0 20559000.0 8047200.0 False True 13657450.670908486 16890085.82179983 6456667.39278695 1.0 1.236693891765403 0.4727578776132937 23.703184876413527 -6.823489203965374 1.3567271095262037 1.1271454577317366 0.4548008102552947 0.8922190830663101 0.10482814950875931 0.18898471479704096 0.6825662650485038 0.0607021762057353 0.13979450698394602 1.5014497295113343e-07 6.823489203965374 -0.6723446474764418 down HLWDYTFGPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLWDYTFGPEK 11 0 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 0 15022200.0 2829400.0 6044200.0 6148600.0 False True 3875505.6416599816 5777147.258503441 4696427.314391928 1.0 1.490682195479642 1.211823113842849 21.88595312206583 -10.120225202574789 4.6380610818756045 0.9999708149439112 1.3512526546673895 0.6790219002758549 0.11384374337957395 13782741.205683136 30073871.276199162 2517.8699668883132 0.03897174471713711 7.581843180454539e-11 10.120225202574789 0.3512818397234784 HLYPNTPYAYTFWTYMMNAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLYPNTPYAYTFWTYMMNAR 20 0 P27695 P27695 APEX1 DNA-(apurinic or apyrimidinic site) lyase;DNA-(apurinic or apyrimidinic site) lyase, mitochondrial 0 51278000.0 12716000.0 16775000.0 21787000.0 False True 19291101.664123558 13781370.186326763 17480789.900418654 1.0 0.7143900035505247 0.9061581969125375 24.20143219847386 -10.05300094523499 4.866258422136347 1.0000046750309581 0.8102741008221718 0.5661765323557515 0.07828903711330346 3.9709350234607885e-06 7.726476603360965e-07 0.07580490176944507 0.02526767807640864 8.851136833929717e-11 10.05300094523499 -0.18973057420878636 HLYPNTPYAYTFWTYMMNAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLYPNTPYAYTFWTYMMNAR 20 0 P27695 P27695 APEX1 DNA-(apurinic or apyrimidinic site) lyase;DNA-(apurinic or apyrimidinic site) lyase, mitochondrial 0 38495100.0 12716000.0 9919100.0 15860000.0 False True 16461112.669833584 9367093.365410347 12973642.737342378 1.0 0.5690437550176275 0.788138869926922 23.97255852056631 -10.113196489350486 4.812337946393587 1.0000153988787615 0.678591312471952 0.7415608848740309 0.08944520612672589 1.665699539082891e-05 3.069512381211683e-06 0.08660962213081863 0.028868316141569886 7.705547654373378e-11 10.113196489350486 -0.3214240864068094 HLYTK(ub)DIDIHEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HLYTKDIDIHEVR 13 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 55025000.0 20763000.0 16158000.0 18104000.0 True False 27220494.069178052 13747289.3833907 16230771.745830594 1.0 0.5050345283393238 0.5962702846091543 24.698189917118256 -10.256450364253109 7.147486187501902 1.0000021780687982 0.5506524064742886 0.9700082361436128 0.03724684152633597 1.2927265833060346e-06 1.3451057291157756e-07 0.036064273840265657 0.012021366410860511 5.540508630874078e-11 10.256450364253109 -0.4493497715945096 HLYTK(ub)DIDIHEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLYTKDIDIHEVR 13 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 75561000.0 22429000.0 20749000.0 32383000.0 True False 21717003.672013868 29034183.904605553 23900920.830823887 1.0 1.3369332318169262 1.1005625449897758 24.372321730257884 -10.312004035623398 4.108042484046671 0.9996820255607004 1.2187478884099665 0.5331311941421448 0.09649792896095732 0.00028880751496048016 4.836818832695862e-05 0.09357218923611446 0.03114457262885013 4.8752395983113476e-11 10.312004035623398 0.2190658628492661 HLYTK(ub)DIDIHEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLYTKDIDIHEVR 13 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 196837000.0 33525000.0 57962000.0 105350000.0 True False 50859876.00579918 47618228.24082698 84527526.32345477 1.0 0.9362631602837062 1.66196878485934 25.600024609015083 -6.885496525435171 1.0486324459286511 0.956694415543194 1.7191506121082492 0.9778566899497457 0.04882503502655936 0.12287419296693346 0.24378963615000762 0.03566932941985401 0.08760009126795261 1.3016777295857845e-07 6.885496525435171 0.7624561965650551 HLYTK(ub)DIDIHEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLYTKDIDIHEVR 13 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 48022000.0 20763000.0 15445000.0 11814000.0 True False 28439642.19897726 14762588.830215022 9023776.516967487 1.0 0.5190849001168485 0.31729571187404026 24.761399978641148 -13.943924430425463 0.12070953057344483 3.265588648171717 2.0411023208007005e-15 0.999695494172663 0.004997225704687327 11.69312510938708 0.10608260956147067 6.368288315672331 0.28002714142294444 1.1378252563102997e-14 13.943924430425463 -3.2655886481717147 HLYTK(ub)DIDIHEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLYTKDIDIHEVR 13 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 72182000.0 22429000.0 35844000.0 13909000.0 True False 18650707.273173355 35650901.25752303 16817307.5920502 1.0 1.9115039840232906 0.9016981150221436 24.15272700569216 -6.6689415001920604 1.9412740746705688 1.5823381324391934 0.9058098014905601 0.2743386261557794 0.3872815553237466 0.4635295888818498 3.3667534494398175 0.16067165473208453 0.4298444644698047 2.143179269609208e-07 6.6689415001920604 -0.6765283309486333 HLYTK(ub)DIDIHEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLYTKDIDIHEVR 13 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 169772000.0 33525000.0 59051000.0 77196000.0 True False 43398773.37654696 55764759.93999922 63147120.097848885 1.0 1.284938619259109 1.4550438914472659 25.371150931107533 -10.71648639785945 0.08127980238803433 3.8364312555409303e-16 2.054965449995754 0.9999519755106424 0.0013009664980374494 2.8377120931527813 0.04708460280945117 0.9069797493799115 0.3654455180627785 1.9209391247885662e-11 10.71648639785945 2.0549654499957537 HLYTLDGGDIINALCFSPNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HLYTLDGGDIINALCFSPNR 20 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6R9L0;D6R9Z1;H0Y8R5;D6RF23 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 73845000.0 60548600.0 8328200.0 4968200.0 False True 58626517.835627936 11653693.690989252 3666879.377194803 1.0 0.19877854119978422 0.06254642971420696 25.805050033576634 -13.999999999999998 0.24927580094973864 6.551849433878072 0.00739105832894541 0.9995413334278906 0.008857143042528926 13.969398132313293 0.1579890899063217 38.817958931196884 0.06312448525911049 1.0000000000000041e-14 13.999999999999998 -6.544458375549127 HLYTLDGGDIINALCFSPNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLYTLDGGDIINALCFSPNR 20 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6R9L0;D6R9Z1;H0Y8R5;D6RF23 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 298285000.0 80143000.0 149493000.0 68649000.0 False True 121582790.2381136 122814806.15585987 55080495.06007436 1.0 1.0101331439699108 0.45302871362141023 26.85736379219578 -6.9027584014778665 0.9436628119562592 1.021442114552394 0.391161393772405 0.9878894338255751 0.028641759077656884 0.10940332584316768 0.16618907514282696 0.022640313003564977 0.05976494420096543 1.250954744256292e-07 6.9027584014778665 -0.630280720779989 down HLYTLDGGDIINALCFSPNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HLYTLDGGDIINALCFSPNR 20 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6R9L0;D6R9Z1;H0Y8R5;D6RF23 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 66299100.0 14252000.0 10687000.0 41360100.0 False True 19521349.545818206 10214813.002816962 31591696.217997864 1.0 0.5232636698012071 1.6183151755901695 24.21854945664915 -6.788407085573915 1.5029251457822153 0.7329938755607512 1.6294159211268895 0.7960298965239807 0.202464438040104 0.2377470974994085 1.060962487586384 0.10604996395751203 0.2485552081899202 1.6277695288944922e-07 6.788407085573915 0.8964220455661382 HLYTLDGGDIINALCFSPNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HLYTLDGGDIINALCFSPNR 20 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6R9L0;D6R9Z1;H0Y8R5;D6RF23 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 113754000.0 60548600.0 4254500.0 48950900.0 False True 50348843.6577852 4231580.164047873 59186306.86661086 1.0 0.08404523036932872 1.1755246509511281 25.58545530901091 -6.684137242881104 1.887069489291989 0.4226192307212415 1.1715205339227157 0.343112793677809 0.3878597075972568 0.42945393910166246 2.9601594248928764 0.1647058940106316 0.4321306563589912 2.0694872597156806e-07 6.684137242881104 0.7489013032014742 HLYTLDGGDIINALCFSPNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLYTLDGGDIINALCFSPNR 20 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6R9L0;D6R9Z1;H0Y8R5;D6RF23 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 196569700.0 80143000.0 73147000.0 43279700.0 False True 103746693.35470836 69076305.1486194 35403238.68722303 1.0 0.6658169327136872 0.34124691151533765 26.62849011428823 -7.311168650737049 0.26245844794053025 1.1072446921465497 1.280710903831592e-12 0.9999227133362691 0.002364359098919359 0.10693034295643591 0.017817804818467443 0.015576572307554505 0.04887086868656033 4.884626365061099e-08 7.311168650737049 -1.107244692145269 down HLYVAVGELLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HLYVAVGELLR 11 0 P32780;P32780-2;F5H0Y9;E9PM51 P32780 GTF2H1 General transcription factor IIH subunit 1 0 8840700.0 3483400.0 3171300.0 2186000.0 False True 5284572.470651778 2605356.737520005 1753936.1418421622 1.0 0.49301182867469895 0.3318974527424427 22.333355329594458 -13.999999999999998 0.16042170480382165 3.499083884537179 0.17424872357814325 0.9995352644056336 0.00613693128170174 12.0125302141748 0.12658665522445253 9.340622917467618 0.14375919519632893 1.0000000000000041e-14 13.999999999999998 -3.3248351609590356 HLYVLVNLCEKPYPLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HLYVLVNLCEKPYPLHR 17 1 Q99538;Q99538-2 Q99538 LGMN Legumain 0 25323100.0 6206900.0 13683000.0 5433200.0 False True 8034954.406290502 12921529.02167633 4444413.349339766 1.0 1.6081645729763154 0.553134856105751 22.937858406789545 -6.750391941078027 1.6483072821685976 1.3574411159725064 0.5509667043095523 0.6506669734376123 0.2555607845199557 0.2993749061552485 1.6004237172742195 0.12246980317836945 0.2972114573646209 1.7766752765123946e-07 6.750391941078027 -0.8064744116629541 HMAAASAECQNYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HMAAASAECQNYAK 14 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5;A0A087WU26 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 7134100.0 1801300.0 3201600.0 2131200.0 False True 2361521.7438140153 2723933.7597390558 1910683.8679139502 1.0 1.1534654579719097 0.8090901017189316 21.171285388551052 -6.785560464183825 1.5139336981924585 1.0862719659264948 0.8058589406796249 0.786614440179429 0.06507182902954164 0.24205410444660871 1.0960079131936742 0.033840193611708314 0.07949499064481569 1.6384739306272818e-07 6.785560464183825 -0.28041302524686984 HMAAASAECQNYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HMAAASAECQNYAK 14 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5;A0A087WU26 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 10204700.0 1531800.0 6930000.0 1742900.0 False True 2323852.5895804088 5693287.355662872 1398415.0510597911 1.0 2.4499348113517145 0.6017658165280986 21.148087125576797 -6.697376663274959 1.839702903842119 1.9025745626938442 0.6073889876204358 0.4055577321345102 0.6123206171690604 0.4008969391264155 2.6358921430924838 0.265688660537337 0.6856350798074967 2.007351083344662e-07 6.697376663274959 -1.2951855750734085 HMAAASAECQNYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HMAAASAECQNYAK 14 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5;A0A087WU26 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 6175600.0 1801300.0 2214100.0 2160200.0 False True 2467289.288302159 2116273.740950413 1650005.2507155195 1.0 0.85773231010406 0.6687522450401244 21.234495450073943 -6.967198492894641 0.3180758707235053 1.0264721506374601 0.49393423426731864 0.9999515481773713 0.0009444064501080577 0.07722271124912024 0.012270177130804208 0.002887239155543348 0.016651678767152074 1.0784537057787277e-07 6.967198492894641 -0.5325379163701415 HMAAASAECQNYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HMAAASAECQNYAK 14 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5;A0A087WU26 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 4559000.0 1531800.0 1701000.0 1326200.0 False True 1982945.296292159 1606337.8547008287 1084845.2079611267 1.0 0.8100767367130421 0.5470878142678174 20.919213447669247 -6.966552347133515 0.3303308632702623 1.031917074560131 0.3166339644206679 0.9999416568320537 0.0014184219679216014 0.077438092567697 0.013023765130210873 0.003832912203650323 0.022932360350731637 1.08005942944493e-07 6.966552347133515 -0.715283110139463 HMEDEDSDLK(ub)EGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HMEDEDSDLKEGGK 14 1 Q8TCT0-2;Q8TCT0 Q8TCT0-2 CERK Ceramide kinase 1 2781120.0 1258700.0 811270.0 711150.0 True False 1724075.4050885052 775425.4088888669 543191.0165939925 1.0 0.4497630478343611 0.3150622153710892 20.71739144361675 -13.999999999999998 0.19765668879148027 4.031836418935879 0.2255334768181525 0.9994869842058054 0.0067107306590471144 12.485549921320102 0.14097952266380737 14.620465846023853 0.087293698111343 1.0000000000000041e-14 13.999999999999998 -3.8063029421177266 HMFVK(ub)QVDMDHVMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HMFVKQVDMDHVMK 14 1 J3KTE1;Q8WU67;J3KSP1 J3KTE1 ABHD3 Phospholipase ABHD3 1 4518400.0 1594100.0 1870600.0 1053700.0 True False 2089880.5372863582 1591513.771541692 944673.2318041147 1.0 0.76153337147597 0.45202259887579127 20.994989045989005 -6.9675502096847906 0.31119092017252575 1.0470170618266093 0.15668348673219476 0.9999564765645743 0.001479989224497281 0.07710590485654442 0.011861402488281403 0.0048709564242551346 0.02744712442371447 1.077580665159344e-07 6.9675502096847906 -0.8903335750944145 down HMFVK(ub)QVDMDHVMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HMFVKQVDMDHVMK 14 1 J3KTE1;Q8WU67;J3KSP1 J3KTE1 ABHD3 Phospholipase ABHD3 1 27953700.0 5618400.0 5475300.0 16860000.0 True False 5440046.96735668 7661615.843312292 12443860.210841833 1.0 1.4083731058364508 2.2874545542551274 22.3751876765498 -6.958581713573201 0.45498891539730424 0.9730531913170584 2.757915257570198 0.9997139034988242 0.009086122746235001 0.08021181340259113 0.023033804532373737 0.011840647961184055 0.07266418941235907 1.1000648459206034e-07 6.958581713573201 1.7848620662531398 up HMFVK(ub)QVDMDHVMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 HMFVKQVDMDHVMK 14 1 J3KTE1;Q8WU67;J3KSP1 J3KTE1 ABHD3 Phospholipase ABHD3 1 20577500.0 6729200.0 6921300.0 6927000.0 True False 9217167.089792307 6615494.080321619 5290985.266043149 1.0 0.7177361564431277 0.5740359499289898 23.13589197360999 -13.999999999999998 0.08674837019098842 2.4671094224573134 0.1937626423189785 0.9998574032202698 0.002112894520326191 12.193507223249279 0.08476451304664313 3.3377132593443535 0.3427334339630674 1.0000000000000041e-14 13.999999999999998 -2.273346780138335 HMFVK(ub)QVDMDHVMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HMFVKQVDMDHVMK 14 1 J3KTE1;Q8WU67;J3KSP1 J3KTE1 ABHD3 Phospholipase ABHD3 1 20383100.0 5618400.0 10939000.0 3825700.0 True False 4671948.5373221 10880069.435778514 4625636.181961778 1.0 2.328807637511955 0.9900871435140276 22.155592951984076 -6.647904121986205 2.016363135746062 1.8636996034366689 0.9957428493320644 0.18551364850462015 0.567444847770535 0.5136455997880192 4.000562004407319 0.2284431679919675 0.6283299703598129 2.2495511783270908e-07 6.647904121986205 -0.8679567541046045 HMLDLQK(ub)QLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HMLDLQKQLGR 11 1 Q9NR46;B7ZC39 Q9NR46 SH3GLB2 Endophilin-B2 1 31402600.0 2142600.0 6734000.0 22526000.0 True False 3250480.845041771 5532265.08701786 18073726.226503477 1.0 1.7019835989671144 5.560323868412526 21.632221721755744 -6.937717835041105 0.680461935205958 0.9545069731317674 6.534474924135397 0.9978494700510033 0.09297421305938594 0.08882333328803772 0.05946720825501426 0.08900903890509773 0.33555513193771563 1.1542029100869964e-07 6.937717835041105 5.5799679510036295 HMLPSGFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HMLPSGFR 8 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 39306000.0 11598000.0 15264000.0 12444000.0 False True 15205090.31519176 12986670.698605983 11156414.25127684 1.0 0.8541002012747466 0.7337289039401631 23.85805104992535 -6.973329181688633 0.15975191827582075 1.1222419181180676 0.4623940675076666 0.9999980742454098 0.00015097180360666972 0.07523649931116082 0.004930128162227199 0.005584611487514974 0.014457894396616123 1.0633367365722702e-07 6.973329181688633 -0.6598478506104011 HMLPSGFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HMLPSGFR 8 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 35099000.0 15320000.0 6407000.0 13372000.0 False True 14833674.985744037 8965348.512063615 9869472.04859886 1.0 0.6043915968685979 0.6653423415359954 23.822372728416312 -10.5201758267547 6.237731723174691 1.0003710536047163 0.63486696920232 0.9795292163265117 0.024883037312964477 0.00012852784636990897 9.886709736687894e-06 0.024116693163234653 0.008030965759680764 3.01872932209843e-11 10.5201758267547 -0.36550408440239635 HMLPSGFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HMLPSGFR 8 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 78948000.0 21416000.0 43212000.0 14320000.0 False True 32489637.719319772 35500480.98310297 11489645.723321028 1.0 1.0926708783210843 0.35364031518544076 24.953476320976662 -6.8754666655183945 1.1048262689345514 1.0546099456447104 0.30562484476691926 0.9698384880158136 0.05708971785640185 0.13171870923785356 0.29722990747918226 0.03995543809124342 0.09559882276694504 1.3320892835422554e-07 6.8754666655183945 -0.7489851008777912 down HMLPSGFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HMLPSGFR 8 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 37421000.0 11598000.0 13170000.0 12653000.0 False True 15886094.024164993 12588105.852633985 9664621.996714888 1.0 0.7923977935347541 0.6083699354928677 23.921261111448242 -6.972547223700025 0.18762002074911088 1.1286700023501925 0.26708273551727985 0.9999960343685155 0.00031852781752132996 0.07548451640371028 0.005968777386125103 0.0066308142922350604 0.020195251967816682 1.0652530253907148e-07 6.972547223700025 -0.8615872668329128 HMLPSGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HMLPSGFR 8 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 57074000.0 21416000.0 18429000.0 17229000.0 False True 27723434.172472175 17403409.949607033 14093498.784468591 1.0 0.6277508710262039 0.5083604973608447 24.72460264306911 -13.999999999999998 0.15909020948633018 2.8297936338499983 0.38980768516159675 0.9995387900230382 0.0044964454942307925 12.003732358630964 0.12601456792970142 6.778083560511242 0.10792814876815873 1.0000000000000041e-14 13.999999999999998 -2.4399859486884017 HMNGYGSHTFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HMNGYGSHTFK 11 0 P04040 P04040 CAT Catalase 0 3965240.0 739840.0 1667800.0 1557600.0 False True 969937.4046207508 1418970.7410334814 1396434.4935542264 1.0 1.462950840202213 1.4397160960095539 19.887532119718912 -10.1222509380975 4.739894806660855 0.9999688068848767 1.4513334681105652 0.9980162827730132 0.00948554461209533 3.126953159568347e-06 5.79051236997982e-07 0.009184972760740722 0.0030614463570829238 7.546560566254953e-11 10.1222509380975 0.4513646612256885 HMNGYGSHTFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HMNGYGSHTFK 11 0 P04040 P04040 CAT Catalase 0 1223350.0 694020.0 529330.0 0.0 False True 671988.7149873405 740694.2294194836 0.0 1.0 1.1022420658261165 0.0 19.358077479809143 -6.959039196405358 1.1881859662140821 1.0599684335517714 6.097791222199402e-20 0.974655045516071 0.0791639884516176 0.10405772122264867 0.29126664065704116 0.05555783558329011 0.10481417553791404 1.0989066552699125e-07 6.959039196405358 -1.0599684335517714 down HMNGYGSHTFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HMNGYGSHTFK 11 0 P04040 P04040 CAT Catalase 0 3959740.0 739840.0 1817900.0 1402000.0 False True 1013378.8414242304 1737579.1670086065 1070876.4750963612 1.0 1.7146392799819712 1.0567385377726282 19.950742181241804 -10.505961111680264 5.487880311603053 0.9992500870840955 1.3856889088772986 0.31424147237526745 0.26858685330187376 0.00246891657518081 0.00022226005697174715 0.2605402120043656 0.0866860341540339 3.1191688734031173e-11 10.505961111680264 0.3864388217932031 HMNGYGSHTFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HMNGYGSHTFK 11 0 P04040 P04040 CAT Catalase 0 2445510.0 694020.0 1273300.0 478190.0 False True 577108.3802990668 1266440.480169738 578177.318099251 1.0 2.1944586552589103 1.0018522305977091 19.13848275524342 -6.645795850117572 2.0233886102269927 1.7776337116742091 1.0068331820533996 0.17727563377058475 0.5103352642043306 0.518885087845204 4.066894699357588 0.20488653865058176 0.5652334769228334 2.2604981184586562e-07 6.645795850117572 -0.7708005296208096 HMNLILCDCDEFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HMNLILCDCDEFR 13 0 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3;J3KRY3;S4R3P3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 10059400.0 2467600.0 3643600.0 3948200.0 False True 3235047.4962723944 3099989.0826415597 3539678.137808672 1.0 0.9582514897272894 1.094165740035437 21.625355463036122 -6.824238190713805 1.353263875519976 0.9775873228447065 1.0974152051839412 0.8938644773162365 0.018519415563237135 0.18805040404548667 0.6754737807725173 0.010750029269573 0.02475574157332491 1.4988625522884093e-07 6.824238190713805 0.11982788233923469 HMNLILCDCDEFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HMNLILCDCDEFR 13 0 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3;J3KRY3;S4R3P3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 8552500.0 2467600.0 3703400.0 2381500.0 False True 3379938.4043826163 3539771.5424939073 1819038.7485320838 1.0 1.0472887724533804 0.5381869522158798 21.688565524559014 -6.884168016735106 1.0562383550391492 1.0312996366157199 0.4990883884032189 0.9768965522193975 0.0349078560985201 0.12400393012177387 0.25049661061369355 0.025354610654919618 0.06201992818100124 1.30566566383945e-07 6.884168016735106 -0.532211248212501 HMNLILCDCDEFRK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HMNLILCDCDEFRK 14 1 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3;J3KRY3;S4R3P3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 15417300.0 4553600.0 5318200.0 5545500.0 False True 5969813.69712513 4524745.290181238 4971704.856192187 1.0 0.7579374365334398 0.8328073719597648 22.50925447863208 -10.218820677154135 7.464161833548126 1.0000003020753692 0.7953724042466024 0.9087577625733237 0.030565523144937008 1.5363426424994234e-07 1.607040137437718e-08 0.029594984185262234 0.009864980175704863 6.041980549477438e-11 10.218820677154135 -0.20462789782876678 HMNLILCDCDEFRK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HMNLILCDCDEFRK 14 1 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3;J3KRY3;S4R3P3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 58821000.0 13028000.0 34365000.0 11428000.0 False True 19764428.47437885 28232297.25502951 9169250.79092967 1.0 1.4284398504934146 0.4639269383790182 24.236402901731786 -6.7859649583454775 1.5125659284598683 1.2407168089207343 0.4547985429165777 0.78794332259696 0.18170124982012126 0.24141755621486014 1.091193643188021 0.09458113418827614 0.22209174840293464 1.6369485955744255e-07 6.7859649583454775 -0.7859182660041566 down HMNLILCDCDEFRK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HMNLILCDCDEFRK 14 1 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3;J3KRY3;S4R3P3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 19906400.0 4553600.0 7937200.0 7415600.0 False True 6237188.976412983 7586508.259189564 5664188.009076014 1.0 1.2163345199062057 0.9081315365777962 22.57246454015497 -6.718061053611475 1.7663046154203963 1.1318905576616025 0.9086652022727212 0.5032750024642754 0.09105722060020269 0.35913477905220914 2.1886448357850274 0.04095012263204841 0.10303481865932519 1.913986835664098e-07 6.718061053611475 -0.22322535538888133 HMNLILCDCDEFRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HMNLILCDCDEFRK 14 1 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3;J3KRY3;S4R3P3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 36008000.0 13028000.0 12107000.0 10873000.0 False True 16865002.820273023 11433234.807091666 8894225.566401253 1.0 0.6779266466144935 0.5273776506998097 24.007529223824235 -13.999999999986477 0.10157173264740088 2.5835056639627707 0.21439641870709397 0.999785820437047 0.0028850743360964437 12.06858040558993 0.09522592721590588 3.9902039739612745 0.2788958507412457 1.0000000000311389e-14 13.999999999986477 -2.3691092452556766 HMQLYCDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HMQLYCDR 8 0 P33992;B1AHB1;B1AHB2 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 6261700.0 1260700.0 3335200.0 1665800.0 False True 1652789.9086361679 2837601.1605077735 1493438.9954819132 1.0 1.7168553278796794 0.903586709767761 20.656471920069478 -6.674010554464058 1.9235387617696291 1.4559856101090571 0.9068361404691111 0.2968102555288459 0.3042269925479376 0.4519461929982024 3.227665322070922 0.1271678291876847 0.33794648001959626 2.1183096542932584e-07 6.674010554464058 -0.549149469639946 HMQLYCDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HMQLYCDR 8 0 P33992;B1AHB1;B1AHB2 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 20395400.0 5195100.0 11337000.0 3863300.0 False True 7881346.512683886 9313823.773614699 3099717.0616554543 1.0 1.181755396571569 0.393297903685228 22.910010701698308 -6.8460341220671035 1.2539609539383605 1.0967617980299973 0.36409047462869426 0.9343449303955587 0.08637849254838363 0.1618782680680765 0.49180386038247725 0.05395045876047884 0.12457714101019993 1.425495589491917e-07 6.8460341220671035 -0.732671323401303 down HMQLYCDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HMQLYCDR 8 0 P33992;B1AHB1;B1AHB2 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 14664800.0 5195100.0 4501700.0 4968000.0 False True 6725159.360730769 4251176.437687664 4063874.9759846753 1.0 0.632130215755322 0.6042793572616674 22.681137023790757 -13.999999999999998 0.36609138595492574 5.999986237265035 0.6012130350976933 0.999784134324614 0.0026495973981572165 22.37009304612201 0.19605009952004404 87.627296930708 0.007880364573404705 1.0000000000000041e-14 13.999999999999998 -5.398773202167342 HMSEFMECNLNELVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HMSEFMECNLNELVK 15 0 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 0 8675900.0 1182400.0 4116800.0 3376700.0 False True 1619565.2331585363 3934906.163562915 2579193.0053194594 1.0 2.429606466600246 1.5925218401295398 20.62717514777464 -9.880162805232063 5.279349604490874 0.999998761868863 2.0110641533788827 0.6604609576361036 0.3417383677791875 4.980431737431838e-06 1.055355000581178e-06 0.3308871560021792 0.11029558392368273 1.3177626524448736e-10 9.880162805232063 1.0110653915100196 HMSFHAYIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HMSFHAYIR 9 0 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 0 3126850.0 1539300.0 546650.0 1040900.0 False True 1490435.7640702215 764930.1957420899 768257.06366935 1.0 0.5132258727160082 0.5154580171716503 20.507302767629202 -9.827579907829142 5.905879250334776 1.0000000578307868 0.5143419449429311 0.9999841563507409 0.0009112691612742836 6.943417881173873e-10 1.3802560275400498e-10 0.0008823326751643749 0.00029411085666089905 1.4873736802112462e-10 9.827579907829142 -0.48565811288785576 HMSFHAYIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HMSFHAYIR 9 0 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 0 34386600.0 6198600.0 14120000.0 14068000.0 False True 9403729.378360825 11600175.679936472 11287453.633776566 1.0 1.233571832323243 1.200316723251355 23.164801590863537 -10.071500088690426 4.449813319294535 0.9999839787306201 1.21694427780312 0.9826821189122793 0.013576341481430951 9423640.258533787 0.0695511362655583 1546.9373159557595 0.004647542790635629 8.482032092346573e-11 10.071500088690426 0.21696029907250003 HMSFHAYIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HMSFHAYIR 9 0 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 0 4795920.0 2105700.0 1691600.0 998620.0 False True 2884234.194402849 1616859.518626854 762766.5232244844 1.0 0.5605853788726779 0.26446067545579716 21.459756882788476 -8.249310350270882 0.23965787711569264 1.2184124369861316 9.945632492556703e-13 0.9995524685844728 0.0063925125521504 0.09129914278039031 0.05310025286789294 0.09963425691562017 0.10684251411688712 5.632350197808121e-09 8.249310350270882 -1.218412436985137 down HMSFHAYIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HMSFHAYIR 9 0 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 0 3455430.0 1539300.0 1201300.0 714830.0 False True 1279996.1525523113 1194828.3584606205 864297.6479995126 1.0 0.9334624608661001 0.6752345671321776 20.28770804306348 -6.945569800960325 0.6055374869905417 1.0028767822001368 0.5924752933995959 0.9988061017971588 0.004839880700257557 0.08531511076127815 0.04371227309925503 0.004940636308103265 0.021740834274375863 1.1335226407007133e-07 6.945569800960325 -0.41040148880054084 HMSFHAYIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HMSFHAYIR 9 0 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 0 38492600.0 6198600.0 19155000.0 13139000.0 False True 8024209.892673044 18089007.411401723 10747836.817524705 1.0 2.2543038695833353 1.3394261816778523 22.935927912955986 -10.175769846843822 4.7380967533168175 0.9999008934240757 1.796865025635245 0.5028679513039821 0.3734972520869169 261936772.2295282 53.66608505129064 283216.86560561066 0.12785804383147392 6.671602352624953e-11 10.175769846843822 0.7969641322111692 HMYHSLYLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 HMYHSLYLK 9 0 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 0 161798510.0 64196510.0 54158800.0 43443200.0 False True 84162246.28988726 46078518.14934889 38948114.400600284 1.0 0.5474962965061162 0.4627741786554501 26.326669874878267 -13.999999999999986 0.23560319927122225 3.932599802798278 0.4237178774950179 0.9995179366484563 0.005177902184873289 13.472294752686508 0.15365156182104375 18.541047893632786 0.042495667804182805 1.0000000000000327e-14 13.999999999999986 -3.50888192530326 HMYHSLYLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 HMYHSLYLK 9 0 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 0 102795060.0 34660700.0 16900460.0 51233900.0 False True 33560415.05080792 23648901.812734623 37814204.60594594 1.0 0.7046665476851814 1.126750207013176 25.00025722230273 -6.718604686037357 1.764239282854989 0.8200538822817967 1.1260445978706564 0.5059252898407747 0.12429955448770477 0.35805733573812215 2.177253749860556 0.05595748426240702 0.1407104150514287 1.911592482546267e-07 6.718604686037357 0.3059907155888597 HMYHSLYLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HMYHSLYLK 9 0 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 0 223209700.0 111010000.0 58623700.0 53576000.0 False True 168410285.91808394 48161842.705941334 42986680.116805 1.0 0.2859792229636593 0.2552497306353013 27.327405015020016 HMYHSLYLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 HMYHSLYLK 9 0 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 0 162939440.0 64196510.0 51629630.0 47113300.0 False True 87931694.59245127 49348462.23024504 35986108.868871205 1.0 0.561213592652421 0.40925071483792974 26.389879936401158 -13.999999999999998 0.14790693988604914 3.115175236567696 0.23797015751259035 0.9995733757269725 0.005173398133870717 11.950456638120576 0.12100914174212941 7.269530555522399 0.15408026857094298 1.0000000000000041e-14 13.999999999999998 -2.8772050790551056 HMYHSLYLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HMYHSLYLK 9 0 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 0 103704100.0 29757000.0 40212100.0 33735000.0 False True 24744263.958616946 39995469.43582308 40788832.52698343 1.0 1.616353167857921 1.6484156730303197 24.560590792735045 -11.385908912901435 0.48973781819170537 1.425627918633912e-16 1.6472509383427274 0.9998320735011833 0.003866805092472553 3.813049600908469 0.2406552438559095 4.096354677462919 0.006652176428530702 4.112359629619597e-12 11.385908912901435 1.6472509383427272 HMYHSLYLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HMYHSLYLK 9 0 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 0 255223200.0 111010000.0 81416700.0 62796500.0 False True 143704633.33424234 76885789.07396872 51368181.34650199 1.0 0.5350265143862147 0.357456681490741 27.098531337112465 -13.999999999999433 0.1333921645823648 3.2116545525440534 0.11917239721812618 0.9996305391529432 0.005207505926611361 11.932957082805414 0.11389922748749262 6.8998666787121055 0.21221761125372338 1.0000000000013048e-14 13.999999999999433 -3.092482155325927 HMYVFGDFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HMYVFGDFK 9 0 Q9BS26 Q9BS26 ERP44 Endoplasmic reticulum resident protein 44 0 12170300.0 2260800.0 4983200.0 4926300.0 False True 2963930.6936183423 4239725.984361463 4416573.732406382 1.0 1.4304403249003237 1.490106952202268 21.499080282439536 -11.933854788771404 0.31973324770404793 1.0431356257415775e-07 1.503126335167893 0.9995144631119488 0.0048110554828135685 5.068278199633319 0.17179232207821274 3.4019106433425996 0.019869636171493923 1.1645153330790235e-12 11.933854788771404 1.5031262308543303 HMYVFGDFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HMYVFGDFK 9 0 Q9BS26 Q9BS26 ERP44 Endoplasmic reticulum resident protein 44 0 8671740.0 2802000.0 894140.0 4975600.0 False True 2713052.043737254 1251174.7648785014 3672341.0951995547 1.0 0.4611687297951707 1.3535829891935545 21.37148529203481 -6.743256764061271 1.674953157844406 0.6806030286693673 1.354465437843668 0.6193556435744741 0.22638483779504345 0.31197603540213975 1.7197621546729236 0.10687523191608361 0.26131221547414973 1.8061060023161839e-07 6.743256764061271 0.6738624091743007 HMYVFGDFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HMYVFGDFK 9 0 Q9BS26 Q9BS26 ERP44 Endoplasmic reticulum resident protein 44 0 9282500.0 2260800.0 3114000.0 3907700.0 False True 3096678.855822747 2976413.18337906 2984781.741607741 1.0 0.9611630142991583 0.9638654444245636 21.562290343962427 -10.262712638172571 7.9173922725873265 1.0000000545096237 0.9625142293618627 0.9961170696637803 0.0011032624787947465 1.0616885980896105e-09 9.851441562023605e-11 0.0010682308616681362 0.00035607643390563466 5.4611909495336575e-11 10.262712638172571 -0.037485825147761 HMYVFGDFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HMYVFGDFK 9 0 Q9BS26 Q9BS26 ERP44 Endoplasmic reticulum resident protein 44 0 7475500.0 2802000.0 2756500.0 1917000.0 False True 2329987.149646964 2741650.1873775925 2317835.836793456 1.0 1.176680389757945 0.9947848155062362 21.151890567469085 -6.652854978437659 1.9987081032614338 1.1143929420256216 0.9955555929579912 0.20551185854652565 0.07535748380091016 0.5016104410650203 3.8442574707587136 0.030545991563702024 0.08346325670558395 2.2240524322369427e-07 6.652854978437659 -0.11883734906763033 HNAAFCYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HNAAFCYK 8 0 Q00796;A0A6I8PIS1 Q00796 SORD Sorbitol dehydrogenase 0 8887600.0 2938500.0 3495600.0 2453500.0 False True 4457919.333125753 2871782.868752541 1968564.6495927505 1.0 0.6441980336909634 0.44158821694345346 22.087939080324627 -10.01832763142456 0.11770094809644835 1.7659793876079053 3.285793123527886e-08 0.9998783317395425 0.0025459318228957667 1.6140463984652051 0.055023458454371156 0.6139963749176262 0.24174089483936012 9.586771333517814e-11 10.01832763142456 -1.765979354749974 HNAAFCYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNAAFCYK 8 0 Q00796;A0A6I8PIS1 Q00796 SORD Sorbitol dehydrogenase 0 7876000.0 2148700.0 2353300.0 3374000.0 False True 2943132.456434152 2249323.424677567 2577130.6897112154 1.0 0.7642617034650245 0.8756421016924335 21.48892104192545 -10.07025860555072 4.521874692209273 1.0000109713479401 0.8199519025686701 0.7769928636973666 0.04547085719979266 63116883.627714574 1.2178992488539993 7394.288102924356 0.015565883868574923 8.50631369317364e-11 10.07025860555072 -0.18005906877927003 HNAEKLLNVVK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 HNAEKLLNVVK 11 1 P17028 P17028 ZNF24 Zinc finger protein 24 1 10305200.0 3273500.0 1980700.0 5051000.0 True False 3169584.534323305 2771603.8392140446 3727991.5732480483 1.0 0.8744375829704041 1.1761767300659678 21.59586231519251 -6.793705181071379 1.4817062324039045 0.9301596996381161 1.1797119885711465 0.8130438638663845 0.05351223024293543 0.2298729212696323 0.9969075976072478 0.028422487058903996 0.06636288999269173 1.6080324884730372e-07 6.793705181071379 0.2495522889330304 HNFTIMTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HNFTIMTK 8 0 A0A087X0K1;Q9Y376 A0A087X0K1 CAB39 Calcium-binding protein 39 0 7106200.0 1405400.0 1131400.0 4569400.0 False True 1360786.3462770646 1583173.9201730576 3372537.060938354 1.0 1.1634257828235979 2.478373677223599 20.376009139940468 -6.929988931684024 0.7468847730949478 0.9799958981310816 2.7482481827783234 0.9965360754921627 0.03894819735141288 0.09264341195789806 0.07770865456359438 0.03548143822469142 0.11898716675351372 1.174927498453967e-07 6.929988931684024 1.7682522846472417 up HNFTIMTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNFTIMTK 8 0 A0A087X0K1;Q9Y376 A0A087X0K1 CAB39 Calcium-binding protein 39 0 8255500.0 2488000.0 2808900.0 2958600.0 False True 3407880.8356718863 2684793.5102098407 2259839.6142796683 1.0 0.787819069876754 0.6631216651195275 21.700443458646454 -13.99999999999852 0.057318048950613945 2.3920181100095483 0.06286380530391146 0.9999607553510304 0.0008711750570052906 12.491616229232235 0.06017482935562155 2.555915477482941 0.5657008499154744 1.0000000000034071e-14 13.99999999999852 -2.3291543047056367 HNFTIMTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HNFTIMTK 8 0 A0A087X0K1;Q9Y376 A0A087X0K1 CAB39 Calcium-binding protein 39 0 4902300.0 1405400.0 2033200.0 1463700.0 False True 1168652.3697765316 2022246.7480413984 1769752.9026158499 1.0 1.7304091450463495 1.5143535822840628 20.156414415374744 -10.373283617553948 5.2671879406559725 0.999688811450898 1.6223813636652291 0.9171102975793816 0.08820431414299171 0.00032248147289821744 3.837034447227988e-05 0.08544492768322116 0.02846781997827627 4.233663948235936e-11 10.373283617553948 0.6226925522143311 HNGICIYFSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HNGICIYFSR 10 0 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 0 37561000.0 10008000.0 12653000.0 14900000.0 False True 15182867.682805 10394973.291659787 11955008.469098011 1.0 0.6846515104279259 0.7874012155580711 23.855940971501703 -10.694791505435534 9.75923616384898 1.0002773056884453 0.7360263629929985 0.897962559356257 0.04194739146504777 0.00025334988477932553 7.92325412879088e-06 0.04065647555494621 0.013538462380081098 2.0193355665200636e-11 10.694791505435534 -0.2642509426954468 HNGPNDASDGTVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HNGPNDASDGTVR 13 0 P31942-2;P31942 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 22526500.0 2575200.0 11054000.0 8897300.0 False True 3376112.1382722757 9404786.288154522 7976692.744928105 1.0 2.785685398757939 2.362685958947494 21.686931393583276 -10.110839193346504 5.194656174200996 0.999962141656654 2.574185678854711 0.9486281795842356 0.17268879817675076 7.571882803077835e-05 1.2960904924130014e-05 0.16720919602437445 0.055735069950258544 7.747486116454751e-11 10.110839193346504 1.574223537198057 HNGPNDASDGTVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HNGPNDASDGTVR 13 0 P31942-2;P31942 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 10648200.0 3431300.0 2758700.0 4458200.0 False True 3322375.2596986564 3860263.296430449 3290463.6768668443 1.0 1.1618986401856903 0.9903949492945879 21.663783603109298 -6.65915724915099 1.9758654455669533 1.1042808621197688 0.9911095054622814 0.2321579731676936 0.06894588065080004 0.4863608175343208 3.649224532678562 0.028200290065432728 0.07642409767872345 2.192011109246896e-07 6.65915724915099 -0.11317135665748745 HNGPNDASDGTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HNGPNDASDGTVR 13 0 P31942-2;P31942 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 7767260.0 1688800.0 5094100.0 984360.0 False True 2562033.0678178575 4185018.0546150412 789800.8145396844 1.0 1.6334754251160066 0.30827112438965354 21.28885766579568 -6.776713242611549 1.5484370624999582 1.3602377907083039 0.29880026317741226 0.7555993917148902 0.26754582181906944 0.25575407529334715 1.2109209323274197 0.13611314681911996 0.322095457090041 1.672194371872229e-07 6.776713242611549 -1.0614375275308916 HNGPNDASDGTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNGPNDASDGTVR 13 0 P31942-2;P31942 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 24131200.0 2575200.0 11214000.0 10342000.0 False True 3527321.0321632805 10718528.400261004 7899432.600175859 1.0 3.0387164373545574 2.2394991916375684 21.750141455106167 -10.42815981642422 5.926891757578067 0.999331082378281 2.6391078144960636 0.8486730359761324 0.32627907427320063 0.0028849035298254434 0.00027834100546703344 0.31602070364575524 0.10530611840633948 3.731128303974145e-11 10.42815981642422 1.6397767321177825 HNGPNDASDGTVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HNGPNDASDGTVR 13 0 P31942-2;P31942 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 5552800.0 3431300.0 1380200.0 741300.0 False True 2853277.982363891 1372764.5886517486 896302.4026160609 1.0 0.4811184178817506 0.3141307675438935 21.444188878543574 -13.999999999999998 0.15859683190006896 3.5479870285151907 0.1474053880434169 0.999540129365177 0.006262486301134396 12.000617028284204 0.12580144137874374 9.407231003788711 0.1516920096291477 1.0000000000000041e-14 13.999999999999998 -3.4005816404717737 HNGTGGK(ub)SIYGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HNGTGGKSIYGEK 13 1 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 50840000.0 15798000.0 21577000.0 13465000.0 True False 20711330.98804961 18357795.706487235 12071770.965400375 1.0 0.8863648462322213 0.5828582901005135 24.303916933760178 -6.954029831811543 0.5126998488397629 1.0054640812105677 0.45038236469894605 0.9994807504175247 0.004012331353382653 0.08190682863271039 0.029569515223574448 0.0046001719531740485 0.025053909460747818 1.1116553647356058e-07 6.954029831811543 -0.5550817165116217 HNGTGGK(ub)SIYGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNGTGGKSIYGEK 13 1 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 49420000.0 15798000.0 18474000.0 15148000.0 True False 21638947.52489727 17657757.59465151 11570354.382852823 1.0 0.8160173952238159 0.5347004224461583 24.36712699528307 -6.9649366122367145 0.3591392301805098 1.0244806989864053 0.31660960476348565 0.9999118311743977 0.001796622444530352 0.07798249146491815 0.014935879267165447 0.0037809500218333775 0.024040447757312847 1.0840851308991355e-07 6.9649366122367145 -0.7078710942229196 HNGTGGK(ub)SIYGEKFEDENFILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HNGTGGKSIYGEKFEDENFILK 22 2 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 9528400.0 2815900.0 3128800.0 3583700.0 True False 2726510.795845732 4378146.156476451 2645021.461304497 1.0 1.6057688688221023 0.9701122274427092 21.378624437263394 -6.657064475459278 1.983135115130605 1.3908597112588683 0.9727638275526699 0.22327905666797088 0.2581036721824221 0.4914365108383998 3.7121753768163885 0.10525980609064921 0.28606775010952623 2.2025994403565315e-07 6.657064475459278 -0.41809588370619843 HNGTGGK(ub)SIYGEKFEDENFILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HNGTGGKSIYGEKFEDENFILK 22 2 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 61281000.0 10602000.0 13264000.0 37415000.0 True False 16084009.110021845 10896935.567894986 30019908.850422975 1.0 0.677501205909239 1.8664444073037585 23.939123722608656 -6.83447271751441 1.3079538156934158 0.8281436667696535 1.9014268039378495 0.9144990782605602 0.14679661717327105 0.17535870313184332 0.585130732743842 0.08808097298185859 0.20270348054633805 1.463953500579034e-07 6.83447271751441 1.073283137168196 HNGTGGK(ub)SIYGEKFEDENFILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNGTGGKSIYGEKFEDENFILK 22 2 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 7390800.0 1447000.0 4215600.0 1728200.0 True False 1981995.00370467 4029340.852875006 1320034.7533962433 1.0 2.032972255401005 0.6660131589276888 20.918521895047576 -6.7045690863398475 1.8145809813014855 1.6385213515441317 0.6697053867200303 0.4393783853413802 0.435673367889026 0.3860423196087356 2.4742813961284273 0.191319690059965 0.48926671906124775 1.9743807755079785e-07 6.7045690863398475 -0.9688159648241014 HNGTGGK(ub)SIYGEKFEDENFILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HNGTGGKSIYGEKFEDENFILK 22 2 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 8054500.0 2815900.0 3202100.0 2036500.0 True False 2341545.6155213746 3184849.6517329123 2462322.7342878855 1.0 1.3601484552005045 1.0515800836703402 21.15902971269767 -10.058803865608084 4.865444893417856 0.999994576956984 1.2058642694377644 0.3724382808694132 0.12597251017648978 7.4105056585264975e-06 1.4336074397461233e-06 0.12197557150985687 0.040657452831639546 8.733657053742968e-11 10.058803865608084 0.20586969248078035 HNGTGGK(ub)SIYGEKFEDENFILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HNGTGGKSIYGEKFEDENFILK 22 2 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 67634000.0 10602000.0 14871000.0 42161000.0 True False 13724497.996663693 14043415.777340382 34488130.6083917 1.0 1.0232371180901636 2.5128883123284704 23.710250044701105 -6.910291792379055 0.8937467469725315 0.9543020252398234 2.7066062062734306 0.9910311865532568 0.06702842056031114 0.10422534227764346 0.13772347295954587 0.05495636208078513 0.1520126086315759 1.2294424594101396e-07 6.910291792379055 1.7523041810336073 up HNIAYFPQIVSVAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HNIAYFPQIVSVAAR 15 0 Q96AB3-3;Q96AB3;Q96AB3-2;K7ENV7;K7EKW4 Q96AB3-3 ISOC2 Isochorismatase domain-containing protein 2, mitochondrial 0 47856300.0 11726800.0 17729200.0 18400300.0 False True 15373948.362492757 15084072.467880335 16496413.464140885 1.0 0.9811449936101242 1.0730108541528969 23.87398439211992 -6.853211304223156 1.2194301316823362 0.9899030821269486 1.0769184894981183 0.944854676422068 0.009303232760761213 0.1539624844345177 0.4389430659864438 0.005964350974332377 0.01383378213454559 1.4021313372443212e-07 6.853211304223156 0.08701540737116975 HNIAYFPQIVSVAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HNIAYFPQIVSVAAR 15 0 Q96AB3-3;Q96AB3;Q96AB3-2;K7ENV7;K7EKW4 Q96AB3-3 ISOC2 Isochorismatase domain-containing protein 2, mitochondrial 0 36711300.0 17152700.0 0.0 19558600.0 False True 16608196.92741327 0.0 14435615.914577167 1.0 0.0 0.8691862203747073 23.98539211950589 -9.060209710853615 11.580367006833821 1.0000006695476638 0.4345931101873296 0.36069672181930557 0.35484378856305315 0.0 0.0 0.34357602090231254 0.11452534030077083 8.705431231213673e-10 9.060209710853615 -0.5654075593603342 HNIAYFPQIVSVAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNIAYFPQIVSVAAR 15 0 Q96AB3-3;Q96AB3;Q96AB3-2;K7ENV7;K7EKW4 Q96AB3-3 ISOC2 Isochorismatase domain-containing protein 2, mitochondrial 0 52455300.0 11726800.0 16553900.0 24174600.0 False True 16062514.864854138 15822493.9615731 18465057.37151533 1.0 0.9850570782159261 1.1495744923429216 23.93719445364281 -6.88470971717178 1.0531486674375323 0.9900070964787107 1.1623418102094607 0.9772914312859845 0.011193986912176192 0.12354148262599306 0.24775104761379485 0.008149729505441728 0.01996703950819998 1.3040381074829443e-07 6.88470971717178 0.17233471373075004 HNIAYFPQIVSVAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HNIAYFPQIVSVAAR 15 0 Q96AB3-3;Q96AB3;Q96AB3-2;K7ENV7;K7EKW4 Q96AB3-3 ISOC2 Isochorismatase domain-containing protein 2, mitochondrial 0 33964500.0 17152700.0 12643700.0 4168100.0 False True 14263230.043450914 12575585.878522037 5039630.438883051 1.0 0.8816786828938671 0.3533302361057439 23.765797394940165 -6.94235561819813 0.6372712237068914 1.0057745509226859 0.20040220303718484 0.9984564598026446 0.011045220246837732 0.08670821480980569 0.04983770774108835 0.010954308740354034 0.04502313785002579 1.141942882012191e-07 6.94235561819813 -0.805372347885501 down HNIAYFPQIVSVAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HNIAYFPQIVSVAAR 15 0 Q96AB3-3;Q96AB3;Q96AB3-2;K7ENV7;K7EKW4 Q96AB3-3 ISOC2 Isochorismatase domain-containing protein 2, mitochondrial 0 35208900.0 13793400.0 14770000.0 6645500.0 False True 17855828.208562624 13948036.516126525 5436087.188588199 1.0 0.781147553236307 0.304443295773946 24.089891716347513 -6.95834174085772 0.4582058297268205 1.0141468361757544 0.05228484302972539 0.9997036673226037 0.0049988793700647 0.08029887947295564 0.02336082525175564 0.00645467631091208 0.03938852847012079 1.1006728630756201e-07 6.95834174085772 -0.961861993146029 down HNIICLQNDHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HNIICLQNDHK 11 0 J3KN29;O00233;F5H5V4;F5GX23;O00233-2;F5H169 J3KN29 PSMD9 26S proteasome non-ATPase regulatory subunit 9 0 9385900.0 2334000.0 3355400.0 3696500.0 False True 3059896.602488153 2854787.3992467625 3314021.6393317897 1.0 0.9329685836199151 1.0830502039307455 21.545051472700308 -6.7853184278920855 1.5153013367197672 0.962306559000073 1.0844400222957788 0.785696145625522 0.02841776349450142 0.2424050343611457 1.0996416764597328 0.014766736143248124 0.03468945585156008 1.6393873216498048e-07 6.7853184278920855 0.12213346329570585 HNIICLQNDHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HNIICLQNDHK 11 0 J3KN29;O00233;F5H5V4;F5GX23;O00233-2;F5H169 J3KN29 PSMD9 26S proteasome non-ATPase regulatory subunit 9 0 25625000.0 7564300.0 11392000.0 6668700.0 False True 11475596.12440466 9359008.593897749 5350628.522004954 1.0 0.8155575093823967 0.46626148776933696 23.452065763679293 -6.961097798276035 0.41967506852006 1.0154936203076939 0.2531560573259711 0.9998087726709344 0.003060728069972457 0.079311274174174 0.019699356791900414 0.004517516909103848 0.029078852431930396 1.0937100472284595e-07 6.961097798276035 -0.7623375629817228 down HNIICLQNDHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNIICLQNDHK 11 0 J3KN29;O00233;F5H5V4;F5GX23;O00233-2;F5H169 J3KN29 PSMD9 26S proteasome non-ATPase regulatory subunit 9 0 10082900.0 2334000.0 3816400.0 3932500.0 False True 3196942.8739783694 3647778.8288528733 3003724.4923797753 1.0 1.1410209605383004 0.9395615157307621 21.6082615342232 -6.718525653630938 1.7644940119245425 1.0859304395984783 0.9398989355064348 0.5055756397055218 0.05935324875396995 0.35820647373166853 2.178740092956279 0.026716238319272896 0.06718753084323464 1.911940383584834e-07 6.718525653630938 -0.14603150409204357 HNIICLQNDHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HNIICLQNDHK 11 0 J3KN29;O00233;F5H5V4;F5GX23;O00233-2;F5H169 J3KN29 PSMD9 26S proteasome non-ATPase regulatory subunit 9 0 21747900.0 7564300.0 6856000.0 7327600.0 False True 9792135.464644702 6474457.573091638 5994051.987525223 1.0 0.6611895430233978 0.6121291937971276 23.223192085771743 -13.999999999999998 0.27216146452164053 3.645677922121866 0.5961823934960042 0.9995879931639339 0.003500325867248086 14.990102833038463 0.16516599530381124 21.97154793446331 0.020158063634849083 1.0000000000000041e-14 13.999999999999998 -3.0494955286258616 HNIMDFAMPYFIQVMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 HNIMDFAMPYFIQVMK 16 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13;K7EJJ5;J3KRF5 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 16746100.0 4590500.0 4191200.0 7964400.0 False True 4444777.090212655 5864768.0168192675 5878284.713121506 1.0 1.319474047356259 1.3225150764175369 22.083679637668606 HNIMDFAMPYFIQVMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 HNIMDFAMPYFIQVMK 16 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13;K7EJJ5;J3KRF5 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 19836600.0 4590500.0 5203300.0 10042800.0 False True 3817204.143631114 5175268.790125821 12142703.047339242 1.0 1.3557746967137179 3.18104628163494 21.864084913102882 -6.939232337373914 0.6666656706790468 0.9792155430119022 3.6623458859438838 0.9980616304719426 0.04206345151584634 0.08811857453165968 0.056217352074265176 0.04071130551114567 0.1576362531594017 1.1501849023454576e-07 6.939232337373914 2.6831303429319817 up HNIMDFAMPYFIQVMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HNIMDFAMPYFIQVMK 16 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13;K7EJJ5;J3KRF5 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 11075800.0 4385600.0 2804800.0 3885400.0 False True 5677245.6531002 2648710.4143826487 3178297.067570626 1.0 0.4665484948561729 0.55983081616964 22.436759737366746 -10.442844807161206 6.735858610161445 1.0000859878150723 0.5131896555130379 0.9731995391924811 0.03808234820672374 4.9185333484475654e-05 4.0683624950683326e-06 0.036879522355610025 0.01229102503242608 3.607075169196737e-11 10.442844807161206 -0.48689633230203444 HNINIGITNVDVK(ub)AIPADSPTDQEPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HNINIGITNVDVKAIPADSPTDQEPK 26 1 Q9Y5Y0;Q9Y5Y0-2;H7C3Z2 Q9Y5Y0 FLVCR1 Feline leukemia virus subgroup C receptor-related protein 1 1 11582000.0 3080700.0 3029900.0 5471400.0 True False 4038827.5335412365 2577850.7304576947 4905272.013374805 1.0 0.6382670983223292 1.2145287147415953 21.945505110557747 -6.737013541410829 1.6977095170377454 0.7840300491904117 1.2146469679828256 0.5914480198500497 0.15199883810794076 0.3232359442615341 1.8280972286502628 0.07086404732833951 0.1744620266298434 1.8322572912388225e-07 6.737013541410829 0.4306169187924138 HNINIGITNVDVK(ub)AIPADSPTDQEPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNINIGITNVDVKAIPADSPTDQEPK 26 1 Q9Y5Y0;Q9Y5Y0-2;H7C3Z2 Q9Y5Y0 FLVCR1 Feline leukemia virus subgroup C receptor-related protein 1 1 15343600.0 3080700.0 4516500.0 7746400.0 True False 4219718.042787127 4316946.095931774 5916859.8621158665 1.0 1.0230413625172994 1.4021931802362264 22.008715172080638 -6.9193333811575615 0.8296410037359712 0.9914317247417593 1.46241007661612 0.9939940915218727 0.014290968892553128 0.09856559161231325 0.10765336023262406 0.012269892550728845 0.03652399681402325 1.2041112633639782e-07 6.9193333811575615 0.47097835187436077 HNIQALLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HNIQALLK 8 0 P10644;P10644-2;K7EPB2;K7EIE5;K7EID3;K7EJ40;K7EK41;K7EMU2;K7EMZ6;K7EPR5;K7EQK3;X6RAV4 P10644 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 0 15851500.0 6195200.0 4627800.0 5028500.0 False True 8121967.194402145 3937350.2790231095 4508199.056778009 1.0 0.48477790968385415 0.5550624557909035 22.953397769380192 -10.54598042529071 6.321279575941272 1.0006476327222327 0.5199201827375357 0.9841792066326548 0.028693545794231466 0.0002622204529360993 1.883370167992807e-05 0.027817403181403213 0.009260802083724862 2.8445893171222516e-11 10.54598042529071 -0.48072744998469696 HNIQALLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HNIQALLK 8 0 P10644;P10644-2;K7EPB2;K7EIE5;K7EID3;K7EJ40;K7EK41;K7EMU2;K7EMZ6;K7EPR5;K7EQK3;X6RAV4 P10644 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 0 18606400.0 4223600.0 10468000.0 3914800.0 False True 6407509.986520304 8599903.613142699 3141038.0640822086 1.0 1.342160001503643 0.49021196544213225 22.611332391376664 -6.797741346296807 1.465512492935171 1.1893295629034228 0.4791486768244156 0.8253598789362255 0.14628297105303698 0.22400234227580879 0.9500814838607563 0.07854109039195364 0.18288266442789475 1.593157284683076e-07 6.797741346296807 -0.7101808860790073 down HNIQALLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNIQALLK 8 0 P10644;P10644-2;K7EPB2;K7EIE5;K7EID3;K7EJ40;K7EK41;K7EMU2;K7EMZ6;K7EPR5;K7EQK3;X6RAV4 P10644 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 0 13441500.0 6195200.0 2833600.0 4412700.0 False True 8485732.858984916 2708402.1825378626 3370511.1424092134 1.0 0.31917127578086973 0.3971974134020055 23.016607830903084 -10.531259421209006 6.301756964198217 1.0007137088787847 0.35818434459621734 0.9890368999205358 0.0318540372953268 0.0003197311065089718 2.378238190043374e-05 0.030873508792129998 0.010280846329522548 2.9426633399225666e-11 10.531259421209006 -0.6425293642825674 HNIQALLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HNIQALLK 8 0 P10644;P10644-2;K7EPB2;K7EIE5;K7EID3;K7EJ40;K7EK41;K7EMU2;K7EMZ6;K7EPR5;K7EQK3;X6RAV4 P10644 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 0 7505700.0 2965800.0 2786200.0 1753700.0 False True 2466194.1072173323 2771190.1875826037 2120390.561807349 1.0 1.1236707522220974 0.8597825108745547 21.233854924011833 -6.779298295543717 1.53890946669976 1.070090202428132 0.8577492694142318 0.764790947547843 0.052282437889734565 0.251670124934011 1.1772493837437876 0.026761385467767206 0.06317474337968769 1.6622705262197034e-07 6.779298295543717 -0.21234093301390022 HNK(ub)TTAQVLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HNKTTAQVLIR 11 1 P15121 P15121 AKR1B1 Aldose reductase 1 8378100.0 1828100.0 1998800.0 4551200.0 True False 1770067.9661513502 2796931.2636042964 3359104.1869266443 1.0 1.5801264793722298 1.8977261049643916 20.75537332655163 -9.834495304218919 0.13809690336030497 2.935435211350862e-20 2.4510885432828617 0.9998048703928357 0.005191979766006016 1.3645985083997378 0.06152888293761757 0.8079872801858549 0.3056528210947436 1.463877365544668e-10 9.834495304218919 2.4510885432828617 HNK(ub)TTAQVLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HNKTTAQVLIR 11 1 P15121 P15121 AKR1B1 Aldose reductase 1 6066040.0 1828100.0 3375900.0 862040.0 True False 1520146.1485616066 3357713.356636312 1042288.5783773775 1.0 2.2088095672994656 0.6856502444607792 20.535778601985907 -6.695205119415283 1.8477317123022643 1.7541032192262724 0.6905282638031591 0.394997467812626 0.5107119730920504 0.4055642038585032 2.688385754712343 0.22078141338800839 0.5712265370093295 2.0174133044270252e-07 6.695205119415283 -1.0635749554231133 HNKPEVEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HNKPEVEVR 9 1 F8WDD7;F8WCF6;A0A0A6YYG9;P59998;P59998-3;P59998-2;H7C0A3;F8WE39 F8WDD7 ARPC4;ARPC4-TTLL3 Actin-related protein 2/3 complex subunit 4 0 10915800.0 1761200.0 4951600.0 4203000.0 False True 2308950.25548506 4212840.581185628 3768113.8780228645 1.0 1.8245696593842822 1.6319597484057817 21.13880566104249 -10.140308632366219 4.604752884769568 0.9999230902998876 1.728264703906801 0.9501535974276526 0.07863266694637762 54953576.82375385 7.452097582977356 46670.133929685064 0.026918053392430665 7.239213208905554e-11 10.140308632366219 0.7283416136069135 HNKPEVEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HNKPEVEVR 9 1 F8WDD7;F8WCF6;A0A0A6YYG9;P59998;P59998-3;P59998-2;H7C0A3;F8WE39 F8WDD7 ARPC4;ARPC4-TTLL3 Actin-related protein 2/3 complex subunit 4 0 5301300.0 1416100.0 1472900.0 2412300.0 False True 1371146.680633951 2061036.6510720279 1780446.2625512304 1.0 1.503148189892496 1.298508968951476 20.386951483332517 -10.110705098840425 4.492901377515326 0.9999595010964416 1.4008285793168869 0.8364780039144766 0.08354361216482263 58215211.61752174 2.0226398827310605 24390.689695049507 0.028599200565824726 7.749878630683427e-11 10.110705098840425 0.40086907822044526 HNKPEVEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HNKPEVEVR 9 1 F8WDD7;F8WCF6;A0A0A6YYG9;P59998;P59998-3;P59998-2;H7C0A3;F8WE39 F8WDD7 ARPC4;ARPC4-TTLL3 Actin-related protein 2/3 complex subunit 4 0 2039290.0 481040.0 1186300.0 371950.0 False True 729772.8487346645 974595.4963957957 298433.91946852393 1.0 1.3354778792957607 0.40894083684528865 19.477087950757227 -6.808753369973661 1.4198062162869978 1.1831025165542657 0.3931952048109716 0.8565405293115576 0.14507438095534664 0.20850398272875156 0.828638769349302 0.08035012794397432 0.1859702103294744 1.5532688401394934e-07 6.808753369973661 -0.7899073117432941 down HNKPEVEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNKPEVEVR 9 1 F8WDD7;F8WCF6;A0A0A6YYG9;P59998;P59998-3;P59998-2;H7C0A3;F8WE39 F8WDD7 ARPC4;ARPC4-TTLL3 Actin-related protein 2/3 complex subunit 4 0 8722300.0 1761200.0 3783400.0 3177700.0 False True 2412363.2346404023 3616236.8779692813 2427192.7067858083 1.0 1.499043272605808 1.0061472799504079 21.20201572256538 -10.656779187037444 3.782531275860744 0.9872889401269582 1.252595276281069 0.25935238210105616 0.20122394638772356 0.02238151749752165 0.0020308609720597996 0.20216653834470322 0.06494474943351228 2.2040468051748165e-11 10.656779187037444 0.2653063361541108 HNKPEVEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HNKPEVEVR 9 1 F8WDD7;F8WCF6;A0A0A6YYG9;P59998;P59998-3;P59998-2;H7C0A3;F8WE39 F8WDD7 ARPC4;ARPC4-TTLL3 Actin-related protein 2/3 complex subunit 4 0 3647730.0 1416100.0 1422600.0 809030.0 False True 1177549.8938669057 1414936.17143601 978194.4324679236 1.0 1.2015933921827817 0.8307031723774122 20.167356758766793 -6.7590670538459054 1.6157300469328078 1.1172284122511629 0.8293975230685212 0.6872820652198824 0.08478017511612472 0.2844684981982608 1.463394816194234 0.04140289328384589 0.09959955183131568 1.7415379640717452e-07 6.7590670538459054 -0.28783088918264166 HNLGIFYFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HNLGIFYFK 9 0 E9PCN5;Q9H9A5-4;Q9H9A5-3;Q9H9A5-2;Q9H9A5;Q9H9A5-6;Q9H9A5-5 E9PCN5 CNOT10 CCR4-NOT transcription complex subunit 10 0 12708800.0 3297800.0 5072300.0 4338700.0 False True 4323447.735940628 4315532.611670538 3889772.9437491754 1.0 0.9981692564005592 0.8996923708395193 22.043750818690754 -6.9109264217255575 0.889387909482392 1.002960442778936 0.8867098110497575 0.9912667998395565 0.004379130398172824 0.10380899115577846 0.13546257795982355 0.0036017536335539793 0.010007647879764756 1.2276472018216795e-07 6.9109264217255575 -0.11625063172917849 HNLGIFYFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HNLGIFYFK 9 0 E9PCN5;Q9H9A5-4;Q9H9A5-3;Q9H9A5-2;Q9H9A5;Q9H9A5-6;Q9H9A5-5 E9PCN5 CNOT10 CCR4-NOT transcription complex subunit 10 0 7349770.0 2509900.0 943170.0 3896700.0 False True 2430224.5983498013 1319782.6995665724 2876037.371505773 1.0 0.5430702579764629 1.1834450912309475 21.212658221407043 -6.715129911073835 1.7769748529231792 0.7205745078973059 1.1821768256287504 0.4894191327865982 0.19240079767388454 0.36484680079453274 2.248752254891024 0.08606515687022499 0.2172920552037058 1.9269484163823816e-07 6.715129911073835 0.46160231773144444 HNLGIFYFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HNLGIFYFK 9 0 E9PCN5;Q9H9A5-4;Q9H9A5-3;Q9H9A5-2;Q9H9A5;Q9H9A5-6;Q9H9A5-5 E9PCN5 CNOT10 CCR4-NOT transcription complex subunit 10 0 6112500.0 2509900.0 1889100.0 1713500.0 False True 2087093.0574228845 1878923.043343007 2071784.9276711498 1.0 0.9002583936832587 0.992665334352347 20.99306349684132 -10.356254572072002 5.492678261240843 1.0000155874648133 0.946461864074708 0.3091846939929327 0.037724975555153445 7.203079628752934e-06 8.441838403757055e-07 0.03653768390071713 0.012175683505098903 4.40296697435007e-11 10.356254572072002 -0.053553723390105334 HNLHK(ub)IAPLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HNLHKIAPLVK 11 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 22671300.0 3267000.0 3615300.0 15789000.0 True False 4283068.637673009 3075911.3323290264 14155305.73878253 1.0 0.7181559747312779 3.3049448739334486 22.030213366431024 -6.8798995540777845 1.0803213328503112 0.8255344688129668 3.4879440553459697 0.9736059594691635 0.18824842864452082 0.1277208508247987 0.27280314905636294 0.13423899582464321 0.3245518583373415 1.318561667200837e-07 6.8798995540777845 2.662409586533003 up HNLHK(ub)IAPLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HNLHKIAPLVK 11 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 49504900.0 3506100.0 7417800.0 38581000.0 True False 3394800.774642113 10379766.223315986 28475478.694809496 1.0 3.0575479718423955 8.387967537744963 21.694895481093326 -6.954693970065949 0.5046919868800248 0.8974544713971803 10.779808054563302 0.9995200043181274 0.06820680529053867 0.08165390894005745 0.02857253549483021 0.07930045160082798 0.4397967734582034 1.1099566817906332e-07 6.954693970065949 9.882353583166122 HNLHK(ub)IAPLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HNLHKIAPLVK 11 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 56942000.0 0.0 27771000.0 29171000.0 True False 0.0 22815048.074186653 23405339.06389649 0.0 HNLHK(ub)IAPLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNLHKIAPLVK 11 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 24067600.0 3267000.0 4901600.0 15899000.0 True False 4474898.187355329 4685031.104576367 12143983.650183348 1.0 1.046958144838872 2.7138011060225837 22.093423427953915 -6.912928597647197 0.8755400656739074 0.9530474818947435 2.9432828827695396 0.9919809043624438 0.07137589118580322 0.10251351098907771 0.12849320565468458 0.059296039965674896 0.1672068926218374 1.2220005527525763e-07 6.912928597647197 1.9902354008747962 up HNLHK(ub)IAPLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HNLHKIAPLVK 11 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 34460100.0 3506100.0 13118000.0 17836000.0 True False 2915477.4965657503 13047330.730280878 21565425.1356537 1.0 4.475195142356549 7.396875867180048 21.475300756527602 -7.691763280557681 0.2802007355107499 1.6778618765234384e-21 9.800935178971498 0.9995845062010521 0.053298604530091234 0.13512709118418162 0.040539886212171666 0.34065040947118586 0.7316220932783539 2.0334650829414017e-08 7.691763280557681 9.800935178971498 HNLHK(ub)IAPLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HNLHKIAPLVK 11 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 44627000.0 0.0 26554000.0 18073000.0 True False 0.0 25076246.557158012 14783899.444639916 0.0 HNLLQACK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HNLLQACK 8 0 Q14683;G8JLG1;V9GY57 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 0 7749500.0 2630000.0 2060000.0 3059500.0 False True 3404586.8450505147 1945359.1891144644 2502702.393120998 1.0 0.5713936162158909 0.7350972399953172 21.699048303608 -10.086968819590455 5.017046449275927 1.0000091054697127 0.6532454281042229 0.856780250902927 0.06683172455548239 6.806843810813322e-06 1.2387567079027506e-06 0.06471123734396905 0.02156984634945602 8.185235523707895e-11 10.086968819590455 -0.34676367736548974 HNLSVQTHIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HNLSVQTHIK 10 0 A0A087X211;Q8TCG1;Q8TCG1-2 A0A087X211 KIAA1524 Protein CIP2A 0 5361000.0 1947100.0 1428800.0 1985100.0 False True 2552666.9557432244 1215628.6094187791 1779700.8944237877 1.0 0.4762190409069018 0.6971927498883681 21.28357389216898 -10.276266087702428 5.653093529761849 1.000033490660558 0.5867058953976296 0.8234521534629998 0.09021213892916567 3.8081319688985736e-05 4.8752424795694585e-06 0.08735458810776738 0.029115842641530703 5.293390240147335e-11 10.276266087702428 -0.4133275952629283 HNLSVQTHIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HNLSVQTHIK 10 0 A0A087X211;Q8TCG1;Q8TCG1-2 A0A087X211 KIAA1524 Protein CIP2A 0 2098700.0 569750.0 197250.0 1331700.0 False True 551663.5981153828 276012.9536451611 982887.8198563488 1.0 0.5003283787222659 1.781679674377887 19.07342926086929 -6.800956582445532 1.4521024348940827 0.7246439420247058 1.7997693004785305 0.8349211650277311 0.21424778652032206 0.21939361191741308 0.9132273017113106 0.11606886693116403 0.2697657072762112 1.5814061286719385e-07 6.800956582445532 1.0751253584538247 HNLSVQTHIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNLSVQTHIK 10 0 A0A087X211;Q8TCG1;Q8TCG1-2 A0A087X211 KIAA1524 Protein CIP2A 0 3895590.0 1947100.0 954200.0 994290.0 False True 2666995.4883990083 912040.288882564 759459.1800453356 1.0 0.34197294028047265 0.28476207903195117 21.346783953691872 -13.999999999999998 0.34584494019551704 8.887951298142255 0.27641766598017103 0.9997467133825949 0.0051647778833591226 20.253278952520986 0.1890243824454565 117.13111305515302 0.017315905097696302 1.0000000000000041e-14 13.999999999999998 -8.611533632162084 HNLSVQTHIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HNLSVQTHIK 10 0 A0A087X211;Q8TCG1;Q8TCG1-2 A0A087X211 KIAA1524 Protein CIP2A 0 1917820.0 569750.0 877880.0 470190.0 False True 473772.36920462514 873150.6861944628 568504.555087072 1.0 1.84297511410452 1.1999529563986273 18.853834536303566 -10.406306985275437 5.367225678302072 0.9996605780166514 1.5214640352515811 0.46719825968744266 0.26251269661384113 0.0010668829152207246 0.00011801256315252684 0.2543377461126509 0.08472560851278016 3.923674885804429e-11 10.406306985275437 0.5218034572349297 HNMDIGTWDNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNMDIGTWDNK 11 0 Q9Y5A9;Q9Y5A9-2;Q9BYJ9;Q9BYJ9-2 Q9Y5A9;Q9BYJ9 YTHDF2;YTHDF1 YTH domain-containing family protein 2;YTH domain-containing family protein 1 0 6098300.0 1153000.0 2602200.0 2343100.0 False True 1579295.258653411 2487226.199675333 1789708.037659262 1.0 1.574896262144212 1.1332320716173492 20.590849486167624 -10.199759015758396 5.199219578973854 0.9999755401728915 1.354064166880932 0.46146126761499784 0.1803086507422261 5.112577650021446e-05 7.868775313529486e-06 0.17459514383926145 0.05819436679173823 6.31307551486647e-11 10.199759015758396 0.3540886267080404 HNNLYLVATSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HNNLYLVATSK 11 0 E7ENJ6;Q9BXS5;Q9BXS5-2;K7ENA7;K7EQ90;K7ER75;K7EPJ8 E7ENJ6 AP1M1 AP-1 complex subunit mu-1 0 18770500.0 5443600.0 6008700.0 7318200.0 False True 7136612.315897389 5112225.381729149 6560982.86513131 1.0 0.716337830253333 0.9193413589969267 22.76680797202783 -9.878959968689035 5.410139011799203 1.0000001568453956 0.8178395952223364 0.517745203402397 0.08287584357278477 1.568657887683323e-07 3.248952581601345e-08 0.08024425984003161 0.02674806349595528 1.321417430885397e-10 9.878959968689035 -0.18216056162305916 HNNLYLVATSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HNNLYLVATSK 11 0 E7ENJ6;Q9BXS5;Q9BXS5-2;K7ENA7;K7EQ90;K7ER75;K7EPJ8 E7ENJ6 AP1M1 AP-1 complex subunit mu-1 0 10413300.0 3294100.0 1521800.0 5597400.0 False True 3189530.598599177 2129462.676082163 4131273.021599411 1.0 0.6676414005927426 1.2952605074282222 21.604912688329208 -6.76280210403869 1.6017618190630585 0.8076301686603128 1.2978927108960157 0.70242491013372 0.13985292942400818 0.27820211239259995 1.4073338321218196 0.06886802211238072 0.16505670316110474 1.7266244876967591e-07 6.76280210403869 0.49026254223570287 HNNLYLVATSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNNLYLVATSK 11 0 E7ENJ6;Q9BXS5;Q9BXS5-2;K7ENA7;K7EQ90;K7ER75;K7EPJ8 E7ENJ6 AP1M1 AP-1 complex subunit mu-1 0 17987200.0 5443600.0 6235700.0 6307900.0 False True 7456246.027758632 5960186.155297635 4818103.935278413 1.0 0.7993548138176556 0.6461836046371378 22.830018033550722 -6.9741231657348575 0.12523254310315732 1.2546651436545304 0.18692295147702917 0.9999993350350647 0.00011799992191524502 0.0749861464506141 0.0037448630430665557 0.010162480397375037 0.021451191645517634 1.0613945034706271e-07 6.9741231657348575 -1.0677421921775012 HNNLYLVATSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HNNLYLVATSK 11 0 E7ENJ6;Q9BXS5;Q9BXS5-2;K7ENA7;K7EQ90;K7ER75;K7EPJ8 E7ENJ6 AP1M1 AP-1 complex subunit mu-1 0 7578300.0 3294100.0 2463000.0 1821200.0 False True 2739190.1033733287 2449731.3301327783 2202004.4997226116 1.0 0.8943268768078272 0.80388889292891 21.385317963763484 -6.972936122893263 0.17432956249661985 1.0753943870033122 0.6203893801075219 0.9999971526859617 0.00013510906695128548 0.07536098888890888 0.0054632884221070275 0.0036638152693265367 0.010330473785740778 1.0642995465228685e-07 6.972936122893263 -0.4550050068957904 HNNLYLVATSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HNNLYLVATSK 11 0 E7ENJ6;Q9BXS5;Q9BXS5-2;K7ENA7;K7EQ90;K7ER75;K7EPJ8 E7ENJ6 AP1M1 AP-1 complex subunit mu-1 0 12111100.0 4628400.0 4294900.0 3187800.0 False True 5991555.039403718 4055885.0394794713 2607653.109590166 1.0 0.6769336195371268 0.435221422892859 22.514499055890887 -7.6502119053053415 0.1695842593907384 1.2701247470673562 5.071239225690711e-13 0.9999614123422867 0.0014372092658570517 0.13438838666197722 0.01938543010881176 0.04931585584945706 0.08071089204790907 2.237629065818647e-08 7.6502119053053415 -1.270124747066849 down HNPTVTGHQEQTYLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HNPTVTGHQEQTYLQK 16 0 Q71RC2-5;Q71RC2-3;Q71RC2;Q71RC2-4;Q96J85;Q71RC2-7;Q71RC2-2;X6RLN4 Q71RC2-5 LARP4 La-related protein 4 0 13533900.0 1842900.0 8940300.0 2750700.0 False True 2795814.034036908 7344833.61411727 2207022.9393253596 1.0 2.6270823183157077 0.7894026256598383 21.4148369711336 -6.673032805816926 1.9266285201248103 2.0358315234209576 0.7967216919022193 0.29258013627441015 0.6906679635408379 0.4541709404323029 3.252963852254544 0.2883064514379781 0.767247457678389 2.1230840820246935e-07 6.673032805816926 -1.2391098315187383 HNQLPLVIEFTEQTAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HNQLPLVIEFTEQTAPK 17 0 P07237;H7BZ94;I3L398;I3L312;I3NI03;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 48005300.0 12417000.0 17997000.0 17591300.0 False True 16278807.246399032 15311917.751756547 15771121.023664914 1.0 0.9406044017840209 0.9688130576737174 23.956491660944405 -10.091003545122907 4.19312563576983 1.0000065274724936 0.9547087297181115 0.7746318624206797 0.011516135577909072 16018170.39917854 0.16172797828317775 1081.0334156030485 0.003942279514442119 8.109544380485957e-11 10.091003545122907 -0.04529779775438214 HNQLPLVIEFTEQTAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HNQLPLVIEFTEQTAPK 17 0 P07237;H7BZ94;I3L398;I3L312;I3NI03;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 62700500.0 20295000.0 11836000.0 30569500.0 False True 19650746.33392132 16562176.523924602 22562430.884657722 1.0 0.8428268444611084 1.1481717030619962 24.228080771189045 -6.766756500544002 1.5865732916053652 0.9094803520486668 1.149695366681441 0.718150720369279 0.06618908000453937 0.27168496552685634 1.3491153041881019 0.032891537955910856 0.07854020841031567 1.7109743522596094e-07 6.766756500544002 0.24021501463277406 HNQLPLVIEFTEQTAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HNQLPLVIEFTEQTAPK 17 0 P07237;H7BZ94;I3L398;I3L312;I3NI03;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 109107900.0 17881900.0 69296000.0 21930000.0 False True 27128149.642001525 56929587.38788079 17595525.887739554 1.0 2.0985429577452193 0.6486076684160221 24.693287311781667 -6.704110906748935 1.816536505379239 1.679380928603796 0.6526048755889597 0.43704814346457943 0.4633669537624775 0.3869810034176786 2.4854163213494256 0.20329992196760008 0.5201336059866392 1.976464841431056e-07 6.704110906748935 -1.0267760530148362 HNQLPLVIEFTEQTAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNQLPLVIEFTEQTAPK 17 0 P07237;H7BZ94;I3L398;I3L312;I3NI03;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 75025300.0 12417000.0 25059000.0 37549300.0 False True 17007900.456807777 23951810.520968493 28680928.692108233 1.0 1.4082755588671891 1.6863297598045428 24.019701722467296 -7.838051828150066 0.0852630329122649 1.5878039874691153e-19 2.860703975869752 0.9999962458592067 0.0005461078870715427 0.13059763033446192 0.01190747501012507 0.1767069739359104 0.20983980164397012 1.4519383347775486e-08 7.838051828150066 2.860703975869752 HNQLPLVIEFTEQTAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HNQLPLVIEFTEQTAPK 17 0 P07237;H7BZ94;I3L398;I3L312;I3NI03;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 38250600.0 20295000.0 8775000.0 9180600.0 False True 16876191.720944006 8727727.333298877 11100221.013701638 1.0 0.51716213453936 0.6577444246456288 24.00848604662332 -10.630205241757746 9.883552067793742 1.0000913245185823 0.5874532795925033 0.9198856927758275 0.05739247960537907 0.00011551858956675997 4.322082855799452e-06 0.055582090727731154 0.018523343142431807 2.3431212259032754e-11 10.630205241757746 -0.41263804492607903 HNQLPLVIEFTEQTAPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HNQLPLVIEFTEQTAPK 17 0 P07237;H7BZ94;I3L398;I3L312;I3NI03;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 52049900.0 17881900.0 17994000.0 16174000.0 False True 23148472.054946326 16992618.08200276 13230497.959254451 1.0 0.7340708294555366 0.5715495142767913 24.464413633874116 -10.094247572374677 0.0841191426700861 1.8388629809166668 2.3009123991237015e-11 0.9999610542741324 0.0011021099302252226 1.7572534613084834 0.04066052095727584 0.6086811100981209 0.3021595527597956 8.049194608512108e-11 10.094247572374677 -1.8388629808936576 HNSEKPPEPVKPEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HNSEKPPEPVKPEVK 15 2 Q9UHD1;Q9UHD1-2;E9PPQ5;E9PIZ4;E9PSD5 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 9862700.0 1137500.0 5073300.0 3651900.0 False True 1491273.51556567 4316383.41556851 3274036.4194983793 1.0 2.8944277293969236 2.195463397776813 20.50811345696638 -10.297665962553966 5.580957584057058 0.9998141268287127 2.544945563586895 0.8669170356663077 0.2853509934792216 0.0006600190634588422 8.305953352149997e-05 0.27632155099886274 0.09209663713071671 5.0388802507322665e-11 10.297665962553966 1.5451314367581825 HNSEKPPEPVKPEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HNSEKPPEPVKPEVK 15 2 Q9UHD1;Q9UHD1-2;E9PPQ5;E9PIZ4;E9PSD5 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 21355100.0 3088100.0 15649000.0 2618000.0 False True 4684873.470350733 12856313.683804922 2100551.152489835 1.0 2.744217910082091 0.4483688120466095 22.159578653246506 -6.703524579396876 1.8180377143399191 2.0792547270101442 0.4546215937520235 0.4345992987088442 0.7357799855102576 0.3881440713237274 2.4964808926485973 0.3225597725540803 0.8260293142838563 1.9791350066404815e-07 6.703524579396876 -1.6246331332581208 HNSEKPPEPVKPEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNSEKPPEPVKPEVK 15 2 Q9UHD1;Q9UHD1-2;E9PPQ5;E9PIZ4;E9PSD5 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 8500300.0 1137500.0 3614500.0 3748300.0 False True 1558064.4897816603 3454799.4384468915 2863028.7386616874 1.0 2.2173661367065947 1.8375547080614736 20.571323518489272 -10.063006094257249 4.7785452676279565 0.9999698563625877 2.027460422396792 0.9070404965296276 0.15505736651902768 53768996.11289123 0.3081401763456757 20245.989995408378 0.05308026083202254 8.649557811588373e-11 10.063006094257249 1.0274905660342042 HNSEKPPEPVKPEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HNSEKPPEPVKPEVK 15 2 Q9UHD1;Q9UHD1-2;E9PPQ5;E9PIZ4;E9PSD5 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 7403500.0 3088100.0 2353700.0 1961700.0 False True 3997606.325551515 2222714.5259314147 1604690.7287417746 1.0 0.5560113590286473 0.40141289513303674 21.930704975338955 -13.999999999999998 0.14711301871333382 3.1379015606049814 0.22554597464545295 0.9995761599983555 0.0052232838846531515 11.948058861812466 0.12063944517266538 7.3087862568206985 0.15809430020277446 1.0000000000000041e-14 13.999999999999998 -2.9123555859595283 HNSSGSILFLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HNSSGSILFLGR 12 0 P30740;P30740-2 P30740 SERPINB1 Leukocyte elastase inhibitor 0 16901400.0 4016900.0 7153600.0 5730900.0 False True 6093930.97472617 5876984.188668084 4598185.103057301 1.0 0.9643995334115457 0.7545515566434389 22.538941728195926 -6.93621115787492 0.6939136234918173 1.0025794060432953 0.7037579104153573 0.9976243594441119 0.005278310015912282 0.08953840418666474 0.06280377996207433 0.005000991812121192 0.01838278180268185 1.1582140851492728e-07 6.93621115787492 -0.298821495627938 HNTAVSQLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HNTAVSQLTK 10 0 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 5949500.0 1551500.0 1729300.0 2668700.0 False True 1502248.4817481611 2419818.5081803673 1969687.4107161094 1.0 1.6107977725259095 1.311159528298535 20.51869203313271 -10.075565637572804 4.560820970218285 0.9999728410294972 1.4609786504327202 0.7593709287492931 0.12232680102875429 84944026.66324005 2.5057140155181243 24997.302620718863 0.04187571768454139 8.402999978406258e-11 10.075565637572804 0.461005809403223 HNVIK(ub)TGVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HNVIKTGVR 9 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 3728030.0 459030.0 1457500.0 1811500.0 True False 696382.0695881272 1197397.7375005248 1453456.2309913433 1.0 1.7194551522682393 2.0871534384148993 19.40951953146185 -9.808967662824564 0.16392910209887926 7.326687652203087e-25 2.571745480978824 0.9996724878572865 0.0081710389070085 1.310000278719738 0.07209134603019264 0.8707673506425333 0.2825591454576636 1.5525026035982044e-10 9.808967662824564 2.571745480978824 HNVK(ub)QASDSGTGDQV ddPTM_RPMI8226_Bortezomib_1h_R1 1 HNVKQASDSGTGDQV 15 1 Q5JPI3;Q5JPI3-2 Q5JPI3 C3orf38 Uncharacterized protein C3orf38 1 44180800.0 9493900.0 15843700.0 18843200.0 True False 12446594.839058394 13479881.718258878 16893486.420737673 1.0 1.0830176359527628 1.3572777646561278 23.56924776548139 -6.949266295445808 0.5668504120230964 0.9965334958944516 1.457024088711221 0.9991423731988333 0.004470815703947145 0.08378189692100986 0.037193400769094415 0.004753750913304414 0.02283387838348859 1.1239156136383073e-07 6.949266295445808 0.4604905928167693 HNVK(ub)QASDSGTGDQV ddPTM_RPMI8226_Bortezomib_2h_R1 1 HNVKQASDSGTGDQV 15 1 Q5JPI3;Q5JPI3-2 Q5JPI3 C3orf38 Uncharacterized protein C3orf38 1 77709900.0 16738700.0 22449100.0 38522100.0 True False 16207339.13080113 31413142.70050993 28432006.371771608 1.0 1.938204812461228 1.7542673811112022 23.950143917441867 -10.188985586469334 4.451408291425737 0.9997923733415461 1.846236096802276 0.9657787359368206 0.07509214196325875 8451534.100207152 19345070.02650837 10486.541936167387 0.025706036281859385 6.471640937205855e-11 10.188985586469334 0.8464437234607298 HNVK(ub)QASDSGTGDQV ddPTM_RPMI8226_Bortezomib_8h_R1 1 HNVKQASDSGTGDQV 15 1 Q5JPI3;Q5JPI3-2 Q5JPI3 C3orf38 Uncharacterized protein C3orf38 1 46991000.0 2207700.0 19595300.0 25188000.0 True False 3349242.3044892694 16098365.616222298 20209580.759707417 1.0 4.806569412623361 6.0340754482346135 21.675403322448435 -9.213794272310876 0.39439094880230163 7.162512256343589e-18 6.239968053323129 0.9979116449987289 0.09793977264064054 0.6127763366402429 0.15235029083237261 1.2786460615881463 0.313015619545808 6.112315000667544e-10 9.213794272310876 6.239968053323129 HNVK(ub)QASDSGTGDQV ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNVKQASDSGTGDQV 15 1 Q5JPI3;Q5JPI3-2 Q5JPI3 C3orf38 Uncharacterized protein C3orf38 1 32908700.0 9493900.0 2018000.0 21396800.0 True False 13004051.393000538 1928838.0873663938 16343316.520928537 1.0 0.1483259354392121 1.2567865219085006 23.63245782700428 -6.701472711476604 1.82577066177098 0.47189768448661845 1.2535624200155302 0.42446445357704055 0.35940787842875854 0.3924861686166374 2.5446258981670455 0.15698959622597888 0.40298054519892157 1.9885077526601924e-07 6.701472711476604 0.7816647355289117 HNVK(ub)QASDSGTGDQV ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HNVKQASDSGTGDQV 15 1 Q5JPI3;Q5JPI3-2 Q5JPI3 C3orf38 Uncharacterized protein C3orf38 1 23014800.0 16738700.0 3954500.0 2321600.0 True False 13918970.700141193 3933196.3235932034 2807035.826134422 1.0 0.2825781020972553 0.20166978482869768 23.730549192876143 -13.999999999999998 0.30807075026458425 7.857138663475993 0.18337906451697222 0.9996677475761567 0.006539944601261577 17.133586495113473 0.17653388129079137 75.23141148994662 0.02826122938068112 1.0000000000000041e-14 13.999999999999998 -7.673759598959021 HNVK(ub)QASDSGTGDQV ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HNVKQASDSGTGDQV 15 1 Q5JPI3;Q5JPI3-2 Q5JPI3 C3orf38 Uncharacterized protein C3orf38 1 36217300.0 2207700.0 20767400.0 13242200.0 True False 2857911.170273009 19611675.933988217 10832255.476446126 1.0 6.862241254375573 3.7902701767358806 21.446529644540885 -9.397098202627609 9.546095634006685 0.9999956408180901 5.326255715555749 0.7256071961516727 1.2541269408034421 0.0 0.0 1.2143031889392688 0.4047677296464229 4.00776083930052e-10 9.397098202627609 4.326260074737658 HNWSGLDK(ub)QSDIQNLNEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 HNWSGLDKQSDIQNLNEER 19 1 Q9NXC5;Q9NXC5-2 Q9NXC5 MIOS WD repeat-containing protein mio 1 31496700.0 13898900.0 11414200.0 6183600.0 True False 18221592.49713906 9711245.852203133 5543780.389279607 1.0 0.5329526414185741 0.3042423646643413 24.11914571486228 -10.331489942498923 0.15611847463303813 1.7857409594311342 1.598226575172255e-13 0.9996725968477316 0.005239084197092306 2.0306066890056473 0.07824902171760542 0.8185122078783683 0.1928071334088351 4.661332227075552e-11 10.331489942498923 -1.7857409594309743 HNWSGLDK(ub)QSDIQNLNEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 HNWSGLDKQSDIQNLNEER 19 1 Q9NXC5;Q9NXC5-2 Q9NXC5 MIOS WD repeat-containing protein mio 1 35171600.0 13449200.0 5120700.0 16601700.0 True False 13022262.507719873 7165422.2140977215 12253216.729675718 1.0 0.5502440309316379 0.9409437662934341 23.63447679052579 -10.188116273167998 7.7756146877841905 1.0000001237748737 0.7455938986125361 0.3611600021447178 0.15950249904613703 3.422097629244401e-07 3.581164710378441e-08 0.154437704261901 0.051479210207012786 6.484607986331936e-11 10.188116273167998 -0.2544062251623376 HNWSGLDK(ub)QSDIQNLNEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 HNWSGLDKQSDIQNLNEER 19 1 Q9NXC5;Q9NXC5-2 Q9NXC5 MIOS WD repeat-containing protein mio 1 56846600.0 26819000.0 17484600.0 12543000.0 True False 40686383.73152948 14364336.52219667 10063870.552207798 1.0 0.353050214955948 0.2473522989561962 25.27804272136346 -13.999999999999998 0.2549498252390112 5.613899497615148 0.20681000262705543 0.9995522103471632 0.007040244236712542 14.199729686049919 0.15977358109301962 33.65199868626818 0.04747249098066026 1.0000000000000041e-14 13.999999999999998 -5.407089494988092 HNWSGLDK(ub)QSDIQNLNEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNWSGLDKQSDIQNLNEER 19 1 Q9NXC5;Q9NXC5-2 Q9NXC5 MIOS WD repeat-containing protein mio 1 33435800.0 13898900.0 9484100.0 10052800.0 True False 19037698.9336495 9065061.102275334 7678535.683914903 1.0 0.4761636967718123 0.4033331817398868 24.182355776385172 -13.999999999999998 0.27797655037843017 5.222002853515775 0.38096728038669997 0.9996007087381497 0.005310755967047806 15.289901190584757 0.16698891874493235 36.65479765816952 0.029089414136921184 1.0000000000000041e-14 13.999999999999998 -4.8410355731290755 HNWSGLDK(ub)QSDIQNLNEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HNWSGLDKQSDIQNLNEER 19 1 Q9NXC5;Q9NXC5-2 Q9NXC5 MIOS WD repeat-containing protein mio 1 33595300.0 13449200.0 14601300.0 5544800.0 True False 11183605.700582422 14522639.898768855 6704192.043741447 1.0 1.2985650860359412 0.5994660598050505 23.414882065960068 -6.790648449174776 1.49364142368052 1.1667266596525967 0.5918866816606594 0.8034528951820589 0.12697869414482404 0.23438333102010558 1.0329783888227844 0.06691118749434694 0.15658853624261204 1.619390364364615e-07 6.790648449174776 -0.5748399779919373 HNWSGLDK(ub)QSDIQNLNEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HNWSGLDKQSDIQNLNEER 19 1 Q9NXC5;Q9NXC5-2 Q9NXC5 MIOS WD repeat-containing protein mio 1 54798300.0 26819000.0 14638900.0 13340400.0 True False 34717724.18152456 13824232.34637268 10912584.084063215 1.0 0.39818947446242475 0.31432314016338875 25.049169043455908 -13.999999999999998 0.27764361480828603 5.8416166745563896 0.2884838954021175 0.9995999754713997 0.0061079654661158325 15.272286513038983 0.16688464209601542 41.92717260092085 0.03355087511304082 1.0000000000000041e-14 13.999999999999998 -5.553132779154272 HNYEGTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNYEGTLR 8 0 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 11028000.0 2405000.0 3921900.0 4701100.0 False True 3294193.4926812216 3748617.4900110257 3590797.0021936535 1.0 1.1379469658778112 1.090038278009899 21.651493867173254 -10.100836109102126 4.253674030576086 0.9999831140660029 1.1139926219600018 0.8830211192560999 0.019558639974618132 3.1658997777995635e-06 6.691801408894189e-07 0.018940406213300138 0.006312523900491205 7.928004553149087e-11 10.100836109102126 0.11400950789399888 HNYEGTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HNYEGTLR 8 0 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 6574400.0 2319600.0 2861300.0 1393500.0 False True 1928850.175703462 2845885.6089764144 1684874.407183977 1.0 1.4754311375887474 0.8735123279181051 20.879309655083297 -6.6961496369273075 1.8444580281374132 1.2963316546338406 0.8754201582554768 0.3993507755737905 0.2008306204507978 0.40360951715228494 2.6666663039407394 0.08695222319852473 0.22469901356810382 2.0130305371484397e-07 6.6961496369273075 -0.4209114963783638 HNYEGTLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HNYEGTLR 8 0 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 7098800.0 3011400.0 1782300.0 2305100.0 False True 3898316.6635684823 1683113.4382323837 1885595.452323324 1.0 0.43175390392520796 0.48369478804660976 21.894419856021635 -10.478145124712492 9.535163459893292 1.0000057312397153 0.4577243469930768 0.9931662090008063 0.021204777147743905 2.583563585622952e-06 1.4137251565509406e-07 0.020531653776474888 0.0068438123961043216 3.325484096835062e-11 10.478145124712492 -0.5422813842466385 HNYYFINYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HNYYFINYR 9 0 P29083;E9PER7 P29083 GTF2E1 General transcription factor IIE subunit 1 0 9233700.0 2104400.0 2666500.0 4462800.0 False True 2758888.7790385876 2268668.5939355926 4001032.266200433 1.0 0.8223124510028904 1.450233259346796 21.395655866840386 -6.83112378637703 1.3229678798845304 0.9051292897254467 1.4675109923382885 0.9080890534528995 0.080119510676498 0.17942792488152287 0.6138019054540158 0.04754521478276661 0.10940759731350126 1.475285974549115e-07 6.83112378637703 0.5623817026128418 HNYYFINYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HNYYFINYR 9 0 P29083;E9PER7 P29083 GTF2E1 General transcription factor IIE subunit 1 0 8682700.0 2754700.0 1418700.0 4509300.0 False True 2667253.556346547 1985194.308422764 3328179.0538997035 1.0 0.7442840609206914 1.247792526503725 21.346923547229892 -6.7686214096856885 1.579576079323663 0.8530724106682879 1.2504890196628193 0.7253309231330998 0.10773429121225432 0.2686565308355368 1.3226542589388455 0.05376568585918867 0.12815524598535039 1.7036429888931095e-07 6.7686214096856885 0.39741660899453146 HNYYFINYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HNYYFINYR 9 0 P29083;E9PER7 P29083 GTF2E1 General transcription factor IIE subunit 1 0 8423400.0 2104400.0 4051900.0 2267100.0 False True 2882453.5492716683 3872873.660158517 1731657.6723901276 1.0 1.3436031470956766 0.6007582230866058 21.458865928363277 -6.7809288642775 1.532239774552696 1.19432085453057 0.5946998576401179 0.770672333230893 0.14536385811555386 0.2491308895513887 1.155344198502133 0.07471713338509318 0.17616554043557536 1.6560411942688826e-07 6.7809288642775 -0.599620996890452 HNYYFINYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HNYYFINYR 9 0 P29083;E9PER7 P29083 GTF2E1 General transcription factor IIE subunit 1 0 31520900.0 7176900.0 13039000.0 11305000.0 False True 9290638.527849052 12313368.187797833 9247605.99909556 1.0 1.3253521973638336 0.9953681839386495 23.14734632301546 -6.649452739615214 2.010793776932975 1.2112197275966146 0.9967644203558086 0.19167770964141917 0.13888416452040878 0.5098997268561934 3.9512486905882787 0.05603189767462126 0.1537987571733868 2.241543959694726e-07 6.649452739615214 -0.21445530724080597 HPAK(ub)PDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPAKPDPSGECNPDLR 16 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 29657600.0 11233800.0 10263000.0 8160800.0 True False 14727620.588273957 8731800.404860679 7316398.699921242 1.0 0.592886023409164 0.4967807702587419 23.812021029902116 -13.999999999999998 0.20280411324463604 3.2876368771332576 0.43606220372629045 0.9994872645054974 0.004939151266781058 12.587774243544652 0.1427822110673817 11.436349819831753 0.05993974282758497 1.0000000000000041e-14 13.999999999999998 -2.851574673406967 HPAK(ub)PDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPAKPDPSGECNPDLR 16 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 16608000.0 7955500.0 4314000.0 4338500.0 True False 7702957.007120526 6036602.697212807 3202116.6977898693 1.0 0.7836734245865113 0.4156996715455985 22.87698094247944 -6.963083412400054 0.38954825860536935 1.0227136641140298 0.16344732888070046 0.9998680231461915 0.0027709592141409887 0.07861749589711675 0.017191654521136693 0.0047521849151072335 0.030959244163878265 1.0887209689850958e-07 6.963083412400054 -0.8592663352333293 down HPAK(ub)PDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HPAKPDPSGECNPDLR 16 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 89086900.0 22620900.0 19816000.0 46650000.0 True False 34317559.10930894 16279679.976885317 37429607.05257868 1.0 0.47438338854552475 1.09068383719708 25.032443606730606 -6.680825740689577 1.8988029149869017 0.6676812730406113 1.0883604567551062 0.32792522134326896 0.22272915293309073 0.4367191593834523 3.0449463316071608 0.0940944496802022 0.24791925481204743 2.0853274464053879e-07 6.680825740689577 0.42067918371449486 HPAK(ub)PDPSGECNPDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPAKPDPSGECNPDLR 16 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 27859100.0 11233800.0 6242300.0 10383000.0 True False 15387239.44203008 5966494.545474354 7930749.244597382 1.0 0.38775600834396184 0.5154107905109103 23.875231091425007 -9.81306235880279 6.470331803762381 1.0000000114611995 0.4515833994281974 0.9609505171698943 0.052114846589609375 8.581845541626267e-09 1.5107201636800569e-09 0.05045998398465477 0.016819994410914644 1.5379337979944704e-10 9.81306235880279 -0.5484166120330021 HPAK(ub)PDPSGECNPDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HPAKPDPSGECNPDLR 16 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 29246700.0 7955500.0 7071800.0 14219400.0 True False 6615350.738407 7033702.809757612 17192610.79692273 1.0 1.0632395904455632 2.598896336230053 22.657386217913718 -6.915561764888117 0.8569878113942991 0.9604009634588986 2.822914759669568 0.9928568204579716 0.06248131371022526 0.10085423150681123 0.11966349994407599 0.052605009268124364 0.15147162747466372 1.214613867126077e-07 6.915561764888117 1.8625137962106695 up HPAK(ub)PDPSGECNPDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPAKPDPSGECNPDLR 16 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 148833400.0 22620900.0 25251500.0 100961000.0 True False 29283200.974601958 23846231.827147532 82587133.94734086 1.0 0.8143314608204874 2.8202905146527772 24.803569928823055 -6.884260199256017 1.0557876828156518 0.8769247595370884 2.9745755713096353 0.9769611354396217 0.13737133358583814 0.1239218402945462 0.2500671637291063 0.09981544870947748 0.24420870504733755 1.3053885551387083e-07 6.884260199256017 2.0976508117725468 up HPAKPDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPAKPDPSGECNPDLR 16 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 0 22182600.0 3509600.0 10657000.0 8016000.0 False True 4601119.587014747 9067017.140660632 7186581.214901568 1.0 1.9706110587191683 1.56192011074511 22.133553523124828 -10.110017234587815 4.481223983127421 0.9999383105075905 1.7662655845020336 0.8241644980375796 0.1668473812382533 25578974.48426028 28854173.253315054 16124.952214375278 0.057116296284272346 7.762163125678397e-11 10.110017234587815 0.7663272739944431 HPAKPDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPAKPDPSGECNPDLR 16 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 0 7792900.0 4049900.0 1605500.0 2137500.0 False True 3921338.1413031844 2246584.522571893 1577624.626374519 1.0 0.5729127256098557 0.40231792554625867 21.90291462172378 -13.999999999999998 0.12657812032644483 3.0296805126178628 0.15269477453258334 0.9996613710358655 0.004625871050335094 11.943353160755946 0.11028588208776462 6.050992824818197 0.22175469989110919 1.0000000000000041e-14 13.999999999999998 -2.8769857380852795 HPAKPDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HPAKPDPSGECNPDLR 16 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 0 60978500.0 9184800.0 43610000.0 8183700.0 False True 13934013.098823698 35827454.773514785 6566188.107956865 1.0 2.571222986473245 0.47123452959228085 23.732107488838174 -6.706417071951064 1.8076773523902105 1.96945378378614 0.47660808872877386 0.4481913895267944 0.6624872253968479 0.38233218074256914 2.4330166899724563 0.2918766466100929 0.7448266064496629 1.9659973497513108e-07 6.706417071951064 -1.4928456950573663 HPAKPDPSGECNPDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPAKPDPSGECNPDLR 16 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 0 20830100.0 3509600.0 7289500.0 10031000.0 False True 4807193.963373814 6967425.786847035 7661884.394929805 1.0 1.4493747995050974 1.593837164322052 22.19676358464772 -11.780926633813444 0.19492628665587955 4.205239314236462e-09 1.7054278544631998 0.9994120008479909 0.006131554217049218 4.730386769389705 0.12032680590412562 2.0414764611636325 0.09464691699736599 1.656049699442212e-12 11.780926633813444 1.7054278502579605 HPAKPDPSGECNPDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HPAKPDPSGECNPDLR 16 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 0 7229700.0 4049900.0 1278500.0 1901300.0 False True 3367671.2909904546 1271612.4667376196 2298853.039382055 1.0 0.37759399800674426 0.6826239382484229 21.683319897158057 -10.528294579722882 6.3937562534267105 1.0004529264419997 0.5301089681276432 0.7598511900258493 0.1245279516439596 0.0008047322884199897 5.9369750930809275e-05 0.12068450229516622 0.04019122357119818 2.962821041458373e-11 10.528294579722882 -0.4703439583143565 HPAKPDPSGECNPDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPAKPDPSGECNPDLR 16 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 0 23161300.0 9184800.0 7499600.0 6476900.0 False True 11889904.659475274 7082240.667321774 5298170.658606108 1.0 0.5956515943698347 0.44560245101577856 23.503233810930624 -13.99999999999996 0.1376928391691161 2.9279318965655974 0.25464410326872383 0.9996122901716764 0.004610178575724261 11.93235912917734 0.11608541979649013 6.189561875488916 0.17046350960208634 1.000000000000094e-14 13.99999999999996 -2.6732877932968737 HPALFK(ub)AIGVKPPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPALFKAIGVKPPR 14 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 58439200.0 18952000.0 30707400.0 8779800.0 True False 24846255.53142906 26125975.616507694 7871350.517788511 1.0 1.0515055511467257 0.31680228466747085 24.56652511023319 -6.890077757162962 1.0218864357723887 1.0394027453072765 0.2535060781946926 0.9809492918814973 0.04621927225179808 0.11908152259876632 0.22146159746656718 0.03445786766831659 0.08593108339320919 1.2880189209399545e-07 6.890077757162962 -0.7858966671125839 down HPALFK(ub)AIGVKPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPALFKAIGVKPPR 14 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 84680340.0 24703600.0 35205140.0 24771600.0 True False 23919397.740066987 49262735.99437976 18283174.827929396 1.0 2.0595307845841186 0.7643660190199335 24.511677728983457 -6.68926939421999 1.8692586698486735 1.6647150467223553 0.7689086471301548 0.36694692067161516 0.44817334304234097 0.4182123884208235 2.832672028374015 0.1918569753661875 0.5000240114625683 2.0451756143716077e-07 6.68926939421999 -0.8958063995922004 HPALFK(ub)AIGVKPPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HPALFKAIGVKPPR 14 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 45601000.0 18011000.0 14127000.0 13463000.0 True False 27324003.78047572 11605926.475245211 10802032.14895748 1.0 0.42475204470357264 0.39533123460757374 24.703665561127288 -13.752757553452131 0.42581952639327814 9.999498756850402 0.394566434175584 0.999867866760268 0.003199816591287311 24.801410360734657 0.2181440771112082 206.5358481192961 0.007037402112134949 1.7670239932645033e-14 13.752757553452131 -9.604932322674818 HPALFK(ub)AIGVKPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPALFKAIGVKPPR 14 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 57309400.0 18952000.0 20812400.0 17545000.0 True False 25959066.55854242 19892839.350596797 13401232.350617444 1.0 0.7663156649232677 0.516244770219115 24.62973517175608 -6.970263325466163 0.2518188794892544 1.07760602401248 0.19761318242936568 0.9999843630392777 0.0007810833754240423 0.0762173535836073 0.008723968230101914 0.005509470136539809 0.023896341953196527 1.0708698086191457e-07 6.970263325466163 -0.8799928415831144 HPALFK(ub)AIGVKPPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HPALFKAIGVKPPR 14 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 77578400.0 24703600.0 44538900.0 8335900.0 True False 20542137.955038827 44298960.105420575 10078898.149153149 1.0 2.156492191921746 0.4906450424592185 24.292083004417734 -6.719990201302181 1.7594210612162955 1.7036006723548465 0.49325145430582695 0.5124605838569908 0.4866557621482429 0.35532503090634454 2.1496357657473735 0.21962840230812428 0.5513410701142988 1.905503710092301e-07 6.719990201302181 -1.2103492180490196 HPALFK(ub)AIGVKPPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPALFKAIGVKPPR 14 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 37876500.0 18011000.0 15854000.0 4011500.0 True False 23315594.54988775 14971710.96321396 3281448.1614658916 1.0 0.6421329265775055 0.14074048827897848 24.474791883219737 -7.47124680311925 0.4798320945236002 1.0171779007378428 1.7670484276950664e-28 0.9977658305883876 0.01665777166983783 0.11499986369748867 0.0621180386132753 0.0198953060822294 0.06658401788629578 3.378727735469251e-08 7.47124680311925 -1.0171779007378428 down HPAPEDPDWIK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPAPEDPDWIKR 12 1 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 8439600.0 2202800.0 2537600.0 3699200.0 True False 2887892.1319455467 2158999.9714873265 3316442.269232022 1.0 0.7476040907500336 1.1483954793691566 21.461585425256477 -6.736482441515031 1.6993774158565538 0.8492142001125912 1.1484622222765146 0.5890662869316091 0.10605924697363431 0.3242524289270756 1.8371835918239323 0.049398953883199696 0.12170106928590853 1.8344993342536058e-07 6.736482441515031 0.29924802216392343 HPAPEDPDWIK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPAPEDPDWIKR 12 1 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 8919900.0 1720600.0 2256500.0 4942800.0 True False 1665980.4948088233 3157532.217492046 3648132.3991784705 1.0 1.895299631256717 2.189780979156725 20.667940079146895 -10.456156644791752 0.2409546849721042 2.106136145153756e-15 2.356825698208832 0.999186619857916 0.014429573202311457 2.091928207769941 0.11916587159671999 1.4143869527461734 0.1403237305162979 3.498189687795783e-11 10.456156644791752 2.3568256982088296 HPAPEDPDWIK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 HPAPEDPDWIKR 12 1 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 27025100.0 4596100.0 6978000.0 15451000.0 True False 6972619.719918084 5732721.38063716 12397103.077586116 1.0 0.822176113270739 1.7779691960214574 22.733269369872033 -6.85863693272687 1.1926317567025853 0.9038497142663774 1.8230563132121556 0.9519584833189209 0.0909721950971517 0.1482132846238425 0.40136914473814456 0.059526180750932196 0.13874307772212988 1.384723514793566e-07 6.85863693272687 0.9192065989457782 HPAPEDPDWIK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPAPEDPDWIKR 12 1 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 7344300.0 2202800.0 2191700.0 2949800.0 True False 3017234.688431686 2094863.4470173044 2253117.9930379805 1.0 0.6942991392247925 0.7467493336453447 21.524795486779368 -10.495166458359064 6.162326751536314 1.00021646860213 0.720524236435074 0.974263838096433 0.02141270220668773 6.373017098968179e-05 5.22091393636372e-06 0.020748621890092123 0.006910919920316692 3.1976692576030586e-11 10.495166458359064 -0.27969223216705597 HPAPEDPDWIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HPAPEDPDWIKR 12 1 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 7885200.0 1720600.0 3906000.0 2258600.0 True False 1430755.1355041289 3884957.602719706 2730862.817413511 1.0 2.715319698189191 1.9086863640376082 20.44834535458117 -9.999208751271269 6.761767285541459 0.999999775714051 2.312003031113404 0.7791232189743912 0.329306679698566 1.1137774048448773e-06 1.637201506603552e-07 0.31884987382643737 0.10628327385561477 1.0018235782277658e-10 9.999208751271269 1.312003255399353 HPAPEDPDWIK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPAPEDPDWIKR 12 1 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 24330000.0 4596100.0 6782900.0 12951000.0 True False 5949742.052675543 6405425.652351698 10594050.888481798 1.0 1.076588799252438 1.7805899473772568 22.504395691964483 -6.927606753872502 0.7661727492305332 0.9882912052139281 1.9166912783289984 0.996046916472287 0.022088461535063914 0.09389903415757848 0.08390550487454758 0.01984449314257935 0.06455813855849761 1.1813898795514552e-07 6.927606753872502 0.9284000731150703 HPCNASMECDK(ub)CQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HPCNASMECDKCQR 14 1 Q9Y3S2;D6RBR7;D6R9C8;D6R8Y9;D6RCK7 Q9Y3S2 ZNF330 Zinc finger protein 330 1 3330330.0 552330.0 1098700.0 1679300.0 True False 837924.9907317827 902628.4008177186 1347385.6189366633 1.0 1.0772186183746932 1.6080026659187652 19.67646157714098 -6.933030476897648 0.7214801867340482 0.9927658732243957 1.725886455162 0.9971011266138762 0.014551089793681391 0.091094333034788 0.07019252982735553 0.013504382295007594 0.0472519304547283 1.1667277383104005e-07 6.933030476897648 0.7331205819376042 HPCNASMECDK(ub)CQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPCNASMECDKCQR 14 1 Q9Y3S2;D6RBR7;D6R9C8;D6R8Y9;D6RCK7 Q9Y3S2 ZNF330 Zinc finger protein 330 1 2833930.0 552330.0 1004400.0 1277200.0 True False 715002.0730519952 948504.2570614411 1044762.7051786687 1.0 1.3265755342676684 1.4612023440982291 19.44758789923343 -12.372667404275434 0.14101847231559933 7.308030593486953e-19 1.641131030779924 0.9996322816710151 0.003713318233757311 6.44848653752004 0.10180163769641211 1.997791820516674 0.14456490521821766 4.239675287882458e-13 12.372667404275434 1.641131030779924 HPDADSLYVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPDADSLYVEK 11 0 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 0 6730910.0 1263900.0 612610.0 4854400.0 False True 1223778.1863238818 857228.3677189467 3582887.0111216214 1.0 0.7004769142796887 2.9277258339473162 20.22291065800004 -6.872986429479957 1.1182444995087437 0.827139772184169 3.0657476841878153 0.9675706151178605 0.17772998001922552 0.1340202264629105 0.31141907004109903 0.12311523673510862 0.2930743467891135 1.339718549328716e-07 6.872986429479957 2.2386079120036464 up HPDSHQLFIGNLPHEVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPDSHQLFIGNLPHEVDK 18 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 15531500.0 3056600.0 4638900.0 7836000.0 False True 4007232.2001565075 3946794.202290571 7025205.888219635 1.0 0.9849177699601295 1.7531317221760339 21.934174678870384 -6.902425687064712 0.9458329407739071 0.970150626480601 1.8378534703683231 0.9877339853410292 0.039719831948991355 0.10964141711118826 0.16753326428455165 0.03134735580526642 0.08259670674631399 1.2519134719442174e-07 6.902425687064712 0.8677028438877221 HPDSHQLFIGNLPHEVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPDSHQLFIGNLPHEVDK 18 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 11909100.0 4426200.0 1963300.0 5519600.0 False True 4285692.703779386 2747255.9284742475 4073851.175549382 1.0 0.6410296113978374 0.9505700611611305 22.031096977755023 -10.140954901940297 7.297844814072474 1.0000001098697844 0.795799836279484 0.3671892388369843 0.12636935944527966 2.258181219225229e-07 2.673235093407837e-08 0.12235667178742292 0.04078553538353892 7.228448614478596e-11 10.140954901940297 -0.20420027359030035 HPDSHQLFIGNLPHEVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPDSHQLFIGNLPHEVDK 18 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 16996100.0 3056600.0 5501300.0 8438200.0 False True 4186707.621509119 5258234.37563366 6445270.950184102 1.0 1.2559354153654283 1.5394604861040841 21.997384740393276 -6.969805229534714 0.262794939558369 0.9230678396201576 1.8807706849341002 0.9999808234458324 0.000964829928305191 0.07636594135903702 0.009255960292201245 0.005813517226468644 0.02664048337491126 1.0719999632423367e-07 6.969805229534714 0.9577028453139426 HPDSHQLFIGNLPHEVDK(ub)SELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPDSHQLFIGNLPHEVDKSELK 22 1 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 10786400.0 2676000.0 4205100.0 3905300.0 True False 2591051.844768346 5884218.359306805 2882384.7735113027 1.0 2.270976696659995 1.1124380931748603 21.305106452245454 -6.624147987165935 2.1023104110944777 1.8408929612051024 1.117024425669325 0.09670648715737018 0.5459949852521677 0.574323094886469 4.82939161715466 0.21301970426144148 0.6049015302540718 2.3760305090412247e-07 6.624147987165935 -0.7238685355357775 HPDSHQLFIGNLPHEVDKSELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPDSHQLFIGNLPHEVDKSELK 22 1 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 7608100.0 3250800.0 1576600.0 2780700.0 False True 4452708.609566785 1506940.5988809997 2123955.930314159 1.0 0.3384323410796049 0.47700312698449937 22.08625177255166 -9.93400143015284 6.97078752234152 1.0000000219623615 0.40771773403522343 0.96056569055811 0.056571286453915105 1.930836446867416e-08 2.927251304579854e-09 0.0547749150260046 0.018258304192460693 1.1641221958932005e-10 9.93400143015284 -0.5922822879271381 HPDSSVNFAEFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPDSSVNFAEFSK 13 0 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 19368500.0 2178100.0 8874200.0 8316200.0 False True 2108957.4077316616 12417714.338341637 6137937.7393477345 1.0 5.888082088721649 2.910413324064964 21.008098528242027 -9.390837329325583 9.414551423640628 1.000046946614008 4.399247706393337 0.6347174925415047 1.21562818304102 0.0 0.0 1.1770269093497319 0.39234230896265865 4.065955963414079e-10 9.390837329325583 3.399200759779329 HPDVEVDGFSELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPDVEVDGFSELR 13 0 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 12563200.0 2382200.0 3848800.0 6332200.0 False True 3123087.269257618 3274574.0425048964 5677004.686751453 1.0 1.048505456359946 1.817754099487883 21.574541452856884 -6.919759877605081 0.8265066893995444 0.9828798636448577 1.9411194916428032 0.9941139694294353 0.02873825398944693 0.09831316439320334 0.10634809998176006 0.024729537662257186 0.07390742924130324 1.2029293531253722e-07 6.919759877605081 0.9582396279979455 HPDVEVDGFSELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPDVEVDGFSELR 13 0 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 9360700.0 2283700.0 1196500.0 5880500.0 False True 2211205.1935341777 1674268.6896650724 4340220.638781456 1.0 0.7571747274114721 1.9628303386193051 21.076401478674743 -6.854297961856656 1.2141280407240667 0.8697726184876774 2.0151882080417374 0.9463357848472436 0.12060949551675777 0.15279052612552285 0.4312564848175095 0.07763662891072365 0.18022581000101698 1.398627419486228e-07 6.854297961856656 1.14541558955406 HPDVEVDGFSELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPDVEVDGFSELR 13 0 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 12390200.0 2382200.0 5741400.0 4266600.0 False True 3262963.7165343934 5487725.963729139 3258916.9533852595 1.0 1.6818225516640666 0.9987597891056441 21.637751514379776 -10.44111290930259 5.18000319642245 0.9995666749830765 1.3402911703848643 0.24863825814461527 0.27885920509403106 0.0013972414343283363 0.00015075238651379434 0.27034080340137373 0.0900014214388139 3.6214883353607664e-11 10.44111290930259 0.34072449540178784 HPEK(ub)QGSYSPALPLQPLGGHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HPEKQGSYSPALPLQPLGGHK 21 1 H3BMJ2;Q6ZRI6-2;Q6ZRI6 H3BMJ2 C15orf39 Uncharacterized protein C15orf39 1 9270200.0 1805100.0 3196800.0 4268300.0 True False 1501020.629488843 3179578.2038848815 5160781.795610595 1.0 2.1182774849454624 3.4381817905914094 20.517512374301916 -6.96893420278289 0.28248391666055994 0.7177789681069743 4.879037782714586 0.9999728350760471 0.005193843562572713 0.07665006102540592 0.010262354574315362 0.024036603268620775 0.12077544451315914 1.0741521380280678e-07 6.96893420278289 4.161258814607612 HPELADK(ub)NVPNLHVMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPELADKNVPNLHVMK 16 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783;Q9NQ39 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 11594100.0 1672900.0 3439000.0 6482200.0 True False 1619794.705199161 4812210.634148083 4784317.3581683785 1.0 2.970876876373293 2.9536566225410184 20.62737954505181 -10.084110416328507 4.562062818605409 0.9998700516050598 2.9622667495308472 0.9999422436803681 0.0070301394380645685 527785.4111351012 388877.96520447894 614.7897876651658 0.002406603745605832 8.239286103064653e-11 10.084110416328507 1.9623966979257874 HPELADK(ub)NVPNLHVMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HPELADKNVPNLHVMK 16 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783;Q9NQ39 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 59270800.0 6416800.0 16387000.0 36467000.0 True False 9734754.730917579 13462611.817784624 29259281.465946082 1.0 1.3829430930629791 3.005651634243913 23.21471319973903 -6.943551572598436 0.6256494282767615 0.9822887399508813 3.493111426948257 0.9985930740555075 0.03260975802955047 0.08618307433496623 0.04750706371840314 0.03267328882603638 0.13762869816822257 1.1388025407066918e-07 6.943551572598436 2.5108226869973755 up HPELADK(ub)NVPNLHVMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPELADKNVPNLHVMK 16 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783;Q9NQ39 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 80633800.0 6416800.0 18534000.0 55683000.0 True False 8306674.0940380655 17502566.60730462 45549265.35582827 1.0 2.107048670642647 5.483454008207721 22.98583952183148 -6.951079051684913 0.546868943125328 0.9524150597615185 6.79585681530399 0.9992832662603903 0.05105178853798317 0.08305531857471685 0.03419136359100519 0.055636029434039454 0.2799399329829779 1.1192341383101495e-07 6.951079051684913 5.843441755542472 HPELNISEEGITK(ub)STLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HPELNISEEGITKSTLTK 18 1 P17480;E9PKP7;P17480-2 P17480 UBTF Nucleolar transcription factor 1 1 4431500.0 2012100.0 2419400.0 0.0 True False 1673150.3011437047 2406366.2119866987 0.0 1.0 1.4382247729578115 0.0 20.674135619586828 -6.849576622628203 1.4071661813172913 1.23324762901321 7.971807002940712e-22 0.894560696265391 0.19544483891833717 0.1749956385344949 0.6962730731719478 0.11167130756761862 0.23602935545915574 1.413915245824382e-07 6.849576622628203 -1.23324762901321 down HPELNISEEGITK(ub)STLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPELNISEEGITKSTLTK 18 1 P17480;E9PKP7;P17480-2 P17480 UBTF Nucleolar transcription factor 1 1 35706800.0 3621500.0 4374300.0 27711000.0 True False 4688103.140437432 4130866.359681264 22667882.338871088 1.0 0.8811381140594586 4.835192754900871 22.160572879391662 -6.899970821058964 0.9614695978898313 0.8354732051312637 5.249966167171305 0.9865512898903457 0.21298607132841557 0.1114261875787337 0.17754852905601343 0.1661544194299649 0.4322339936557908 1.2590099980506027e-07 6.899970821058964 4.4144929620400415 up HPFLLLGTTANR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPFLLLGTTANR 12 0 Q96IJ6;Q96IJ6-2;A0A087WUI8;C9JAH0;F8WD54;C9J255 Q96IJ6 GMPPA Mannose-1-phosphate guanyltransferase alpha 0 2885000.0 1024200.0 1860800.0 0.0 False True 1342736.1183669074 1583175.89334159 0.0 1.0 1.1790670346062604 0.0 20.35674437585449 -6.923920958533008 1.251643677832762 1.0948207511125099 1.4976740778714472e-18 0.9611758107430934 0.10222113207746895 0.1201377131870375 0.37635027089334205 0.06727118835882774 0.13087059875246884 1.1914588334502623e-07 6.923920958533008 -1.0948207511125099 down HPFPGPGLAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPFPGPGLAIR 11 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 26085200.0 6847900.0 8887300.0 10350000.0 False True 8977663.215157937 7561349.482424071 9279081.284210471 1.0 0.8422402691223085 1.0335742232503908 23.097908545847748 -6.687700211068392 1.8746850883263493 0.9008807138312283 1.0328931275845756 0.35961222043213814 0.06675300395753551 0.42164594962603674 2.871243449859531 0.02850543071567815 0.07444336399175365 2.052578563393088e-07 6.687700211068392 0.13201241375334738 HPFPGPGLAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPFPGPGLAIR 11 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 14650200.0 3730700.0 3922300.0 6997200.0 False True 3612270.970581935 5488494.844524284 5164423.408499551 1.0 1.5194028602012906 1.4296888164144468 21.78447468840316 -10.062987815966736 4.687791488922207 0.9999810783848838 1.4745458383195562 0.97389416632873 0.03662560504832436 7.35755992499953e-06 1.4706235565413547e-06 0.03546402433845005 0.011820863193832583 8.649921855950228e-11 10.062987815966736 0.4745647599346724 HPFPGPGLAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HPFPGPGLAIR 11 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 40055100.0 8626900.0 22319000.0 9109200.0 False True 13087638.010870356 18336000.070857085 7308762.627295811 1.0 1.4010167499763926 0.5584477979315507 23.641701414857472 -6.777261668104284 1.546343313395224 1.227871675082091 0.5523142177912077 0.7576520470675658 0.16940138994442513 0.25484959872034874 1.2034305372637946 0.0862974283615368 0.2041133842972387 1.6700840636244344e-07 6.777261668104284 -0.6755574572908833 HPFPGPGLAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPFPGPGLAIR 11 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 27556800.0 6847900.0 6401900.0 14307000.0 False True 9379753.687539194 6119042.889747731 10927981.26191416 1.0 0.6523671189656879 1.1650605789821276 23.16111860737064 -6.724115808641058 1.7447581443358828 0.7894385835069322 1.1644397393376513 0.5317861787614528 0.1462158321961213 0.34736400829430203 2.0687449106345066 0.06648888155499592 0.16609351114229606 1.8874879658569972e-07 6.724115808641058 0.37500115583071914 HPFPGPGLAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPFPGPGLAIR 11 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 29633900.0 8626900.0 10273000.0 10734000.0 False True 11167692.111622153 9701298.519307239 8780522.140140818 1.0 0.8686932288553293 0.7862432141196819 23.41282773694992 HPFVDSNLLYQFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPFVDSNLLYQFR 13 0 Q8TB45;Q8TB45-2 Q8TB45 DEPTOR DEP domain-containing mTOR-interacting protein 0 6472850.0 2234760.0 1854000.0 2384090.0 False True 2929792.001446622 1577390.426835397 2137407.2366061206 1.0 0.5383967278416149 0.7295423141133394 21.48236681447233 -10.20300402873784 5.437983480621622 1.000016961580753 0.6339695209774326 0.8301998841476881 0.07803485882530088 1.6047810358845698e-05 2.3517904121718626e-06 0.07556042529915992 0.02518564238781378 6.266080519084525e-11 10.20300402873784 -0.3660474406033204 HPFVDSNLLYQFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPFVDSNLLYQFR 13 0 Q8TB45;Q8TB45-2 Q8TB45 DEPTOR DEP domain-containing mTOR-interacting protein 0 6952700.0 2234760.0 2558240.0 2159700.0 False True 3061011.164118205 2445208.497831619 1649623.3404176964 1.0 0.7988237764353328 0.5389145128756525 21.54557687599522 -6.967619568446583 0.3098153673261028 1.0401285794707835 0.2893501606298149 0.9999574098571858 0.0012317622564301165 0.07708293116599524 0.011780953589103305 0.004115720676593145 0.02307911709900756 1.0774085844722281e-07 6.967619568446583 -0.7507784188409686 HPGDSK(ub)NYNECIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPGDSKNYNECIR 13 1 Q9H832-2;Q9H832;D6RB11 Q9H832-2 UBE2Z Ubiquitin-conjugating enzyme E2 Z 1 2091040.0 435100.0 532140.0 1123800.0 True False 595968.2281353847 508628.2952483407 858381.5853875108 1.0 0.8534486760136427 1.4403143403686853 19.184875895169018 -6.840581406050883 1.279703178169606 0.9220439151504942 1.459838878308572 0.9254491796089694 0.06809385950726703 0.1681193214863752 0.5345602112881548 0.04172026096441891 0.09613025019451307 1.4435060018724963e-07 6.840581406050883 0.5377949631580778 HPGFEATFFQLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPGFEATFFQLPR 13 0 Q9Y5Y6 Q9Y5Y6 ST14 Suppressor of tumorigenicity 14 protein 0 1040000.0 1040000.0 0.0 0.0 False True 1363450.0713743262 0.0 0.0 1.0 0.0 0.0 20.378830440021414 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 HPGLLLILGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPGLLLILGK 10 0 O14497;A0A1B0GTU5;O14497-3;H0Y488;O14497-2 O14497 ARID1A AT-rich interactive domain-containing protein 1A 0 12573600.0 3012600.0 5390000.0 4171000.0 False True 3949547.774059897 4585833.010055441 3739424.931057185 1.0 1.161103314200826 0.9467982526043183 21.913256042494616 -6.705564831296186 1.8110926185171898 1.0994881574326623 0.9473660458365564 0.4440081775210185 0.06793698620480311 0.3840470825530404 2.452703365836058 0.029883879643870882 0.07632799383646854 1.9698591255317598e-07 6.705564831296186 -0.1521221115961059 HPGLLLILGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPGLLLILGK 10 0 O14497;A0A1B0GTU5;O14497-3;H0Y488;O14497-2 O14497 ARID1A AT-rich interactive domain-containing protein 1A 0 14747000.0 4696700.0 4622500.0 5427800.0 False True 4547605.8293435965 6468288.356019055 4006096.3494903482 1.0 1.4223502648981101 0.8809242708857619 22.116675781185023 -6.698508157583051 1.8357906699048832 1.262632507700529 0.8825558331064791 0.4107413018016379 0.17832662592428639 0.3986020921643168 2.6104993055705243 0.07751956460242805 0.19975738097238688 2.002128014205969e-07 6.698508157583051 -0.3800766745940498 HPGLLLILGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HPGLLLILGK 10 0 O14497;A0A1B0GTU5;O14497-3;H0Y488;O14497-2 O14497 ARID1A AT-rich interactive domain-containing protein 1A 0 30339500.0 8487500.0 10894000.0 10958000.0 False True 12876158.01936527 8949880.584789496 8792146.496937983 1.0 0.6950738388989327 0.6828237494223756 23.61819885135534 HPGLLLILGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPGLLLILGK 10 0 O14497;A0A1B0GTU5;O14497-3;H0Y488;O14497-2 O14497 ARID1A AT-rich interactive domain-containing protein 1A 0 21392500.0 3012600.0 9856500.0 8523400.0 False True 4126439.6324538235 9421007.238913199 6510348.464933181 1.0 2.2830837424152293 1.577715668909894 21.976466104017508 -10.163476776045012 4.851303757613829 0.9999186346904027 1.9303997056660778 0.6987749621400348 0.28796531016847404 0.00025344231349384426 4.370221950954812e-05 0.2788453578151822 0.09294040429198268 6.863145781932448e-11 10.163476776045012 0.9304810709756751 HPGLLLILGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HPGLLLILGK 10 0 O14497;A0A1B0GTU5;O14497-3;H0Y488;O14497-2 O14497 ARID1A AT-rich interactive domain-containing protein 1A 0 10300400.0 4696700.0 2434200.0 3169500.0 False True 3905514.1490888265 2421086.4814491323 3832227.7958877706 1.0 0.6199149174799385 0.9812351587003842 21.8970810566193 -10.616006958058453 9.310245705162174 1.0000530530000689 0.8005750387129262 0.28885096063201665 0.14750837078823756 0.00016248195903861541 6.7013049680690755e-06 0.14286217865700696 0.04760812195741936 2.4209902584775684e-11 10.616006958058453 -0.19947801428714262 HPGLLLILGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPGLLLILGK 10 0 O14497;A0A1B0GTU5;O14497-3;H0Y488;O14497-2 O14497 ARID1A AT-rich interactive domain-containing protein 1A 0 29089900.0 8487500.0 13139000.0 7463400.0 False True 10987236.063637357 12407803.099890767 6105137.7809508955 1.0 1.1292924833894145 0.5556572868363193 23.38932517344779 -6.847501097461897 1.247103952857637 1.0688740108549823 0.5338091879908043 0.936589111604581 0.06186517875632375 0.1602258653283336 0.4807961989695838 0.03884156610559362 0.08974914910710159 1.420688622776344e-07 6.847501097461897 -0.535064822864178 HPGSFDVVHVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPGSFDVVHVK 11 0 P62701;C9JEH7;P22090 P62701 RPS4X;RPS4Y1 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1 0 25701600.0 5390100.0 11260000.0 9051500.0 False True 7066473.297802651 9580051.891136227 8114937.608118952 1.0 1.3557048172976445 1.1483716510529127 22.752558950526296 -10.132743284744652 4.080695642275152 0.9999305120767729 1.2520382339790472 0.6633345288531252 0.08464341090208219 26345098.379103653 32017609.306610838 22043.479633519855 0.03097631813301838 7.366424045741006e-11 10.132743284744652 0.2521077219022744 HPGSFDVVHVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPGSFDVVHVK 11 0 P62701;C9JEH7;P22090 P62701 RPS4X;RPS4Y1 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1 0 17512000.0 4518800.0 3371300.0 9621900.0 False True 4375353.167466068 4717477.671097243 7101635.7391873645 1.0 1.0781935744467714 1.6231000029879166 22.060968041672123 -6.932756394106905 0.7238059656742666 0.9925018720598616 1.7432474078516145 0.997052872303349 0.015045568393701657 0.09123143505600753 0.0708515003515636 0.01393934604861428 0.04857886814948796 1.1674642913533764e-07 6.932756394106905 0.7507455357917528 HPGSFDVVHVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPGSFDVVHVK 11 0 P62701;C9JEH7;P22090 P62701 RPS4X;RPS4Y1 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1 0 25169900.0 5390100.0 9221800.0 10558000.0 False True 7382965.631975493 8814350.38358544 8064417.848835513 1.0 1.1938766646035361 1.0923006080251358 22.815769012049188 -10.140731837614831 4.644152780971392 0.9999864545602359 1.1430886363105746 0.7257160442317172 0.04146825146153579 6.279121524578831e-06 1.1617632585461221e-06 0.040155564413701494 0.013383820607259657 7.232162277071429e-11 10.140731837614831 0.14310218175033862 HPGSFDVVHVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HPGSFDVVHVK 11 0 P62701;C9JEH7;P22090 P62701 RPS4X;RPS4Y1 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1 0 11744700.0 4518800.0 3741400.0 3484500.0 False True 3757582.416782554 3721244.3355902443 4213092.839492334 1.0 0.9903293987564951 1.1212243331444511 21.8413733171064 -6.8891154646734405 1.0276234215654168 0.9928169794022594 1.1322884036062844 0.9803252695063265 0.008353729755903526 0.11986282172316139 0.22607433803802993 0.006201187452310822 0.015410920632336757 1.2908760263455292e-07 6.8891154646734405 0.13947142420402492 HPGSFDVVHVK(ub)DANGNSFATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPGSFDVVHVKDANGNSFATR 21 1 P62701;C9JEH7;P22090 P62701 RPS4X;RPS4Y1 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1 1 12007700.0 2371300.0 2465200.0 7171200.0 True False 2296024.3794839964 3449567.2158481716 5292847.588611436 1.0 1.5024087926380902 2.3052227301701995 21.13070653014175 -6.964185264873308 0.371776612826299 0.9394931534074064 2.896160988213641 0.9998953438968727 0.005499102555953637 0.07823861025367175 0.015841944691789255 0.010553978459219552 0.06811803464882327 1.0859622661743109e-07 6.964185264873308 1.9566678348062347 HPGSFDVVHVK(ub)DANGNSFATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPGSFDVVHVKDANGNSFATR 21 1 P62701;C9JEH7;P22090 P62701 RPS4X;RPS4Y1 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1 1 5800900.0 1085500.0 1399800.0 3315600.0 True False 1486838.6845344964 1337952.2074804162 2532523.5669254586 1.0 0.8998637319550951 1.7032941053173822 20.503816699130994 -6.8756663682324675 1.103645405972659 0.9408702662905696 1.7557130973131685 0.9700202653771154 0.06189704583556145 0.13153989731235788 0.29605136032966145 0.04335709407980608 0.10379010451337391 1.3314768864176706e-07 6.8756663682324675 0.8148428310225989 HPGSFDVVHVK(ub)DANGNSFATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPGSFDVVHVKDANGNSFATR 21 1 P62701;C9JEH7;P22090 P62701 RPS4X;RPS4Y1 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1 1 23677300.0 4023100.0 3092200.0 16562000.0 True False 5207982.257156932 2920116.3517377414 13547885.940470645 1.0 0.5607001344378332 2.6013694501076348 22.31229310278254 -6.850369545858209 1.2333005499244742 0.7655019329539798 2.6835367614914993 0.940848091937606 0.21328951283875877 0.1570446630058323 0.4594789764231438 0.13531531279990994 0.3132035461953818 1.4113361124211205e-07 6.850369545858209 1.9180348285375195 up HPHDIIDDINSGAVECPAS ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPHDIIDDINSGAVECPAS 19 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 59192900.0 3810200.0 35214300.0 20168400.0 False True 4995209.098029282 29960463.70426628 18081567.43695368 1.0 5.997839753312094 3.61978189143018 22.25211363940914 -9.861279514297104 10.542951778132553 0.9998966731915673 4.808810822371138 0.7737744387039325 0.9708380585702951 0.0 0.0 0.9400099073486018 0.31333663578286725 1.3763233745469184e-10 9.861279514297104 3.8089141491795706 HPHDIIDDINSGAVECPAS ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPHDIIDDINSGAVECPAS 19 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 56522100.0 3810200.0 25450900.0 27261000.0 False True 5218933.906783361 24326395.083128504 20822513.25791861 1.0 4.661180907370762 3.989802061078862 22.31532370093203 -10.374488869882157 5.12013604297539 0.9979147713818353 4.325491484225081 0.9703375029993508 0.2740892662532139 0.006524315660384215 0.0007970573648506387 0.2653894187031968 0.08846193029760657 4.221930988955608e-11 10.374488869882157 3.3275767128432454 HPHDIIDDINSGAVECPAS ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPHDIIDDINSGAVECPAS 19 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 20741700.0 5838900.0 7663000.0 7239800.0 False True 7558571.151926018 7236547.313681617 5922230.686621149 1.0 0.9573962020371608 0.7835119320285939 22.84968210709622 -6.944411970595443 0.6171558736757675 1.0019074030950403 0.7298335184722224 0.9986865224325555 0.003393729516697618 0.08581030907293076 0.045868476823373465 0.003426668848036594 0.0147002580335981 1.136548647270463e-07 6.944411970595443 -0.2720738846228179 HPIGVLLNAITELQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPIGVLLNAITELQK 15 0 Q9Y316;Q9Y316-3;Q9Y316-2 Q9Y316 MEMO1 Protein MEMO1 0 2336590.0 1127500.0 579460.0 629630.0 False True 1478163.4187255304 493006.8267173888 564481.9274374335 1.0 0.33352660502345427 0.38188059607382835 20.4953743451357 -10.022262451685046 7.517661653762814 1.0000000286705095 0.3577036005486413 0.995767345134076 0.019740434183420308 9.491682132792514e-09 1.2123546798432249e-09 0.01911359406426197 0.006371197736607513 9.500305002434622e-11 10.022262451685046 -0.6422964281218682 HPIGVLLNAITELQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPIGVLLNAITELQK 15 0 Q9Y316;Q9Y316-3;Q9Y316-2 Q9Y316 MEMO1 Protein MEMO1 0 19523300.0 8781500.0 4878500.0 5863300.0 False True 8502736.089250082 6826510.491041416 4327525.834770395 1.0 0.8028604462594223 0.5089568568688895 23.01949572907077 -6.965359097843157 0.35183980387912267 1.0278077255358409 0.2740642170389201 0.9999203513386147 0.0018006269467302366 0.07783935979561878 0.014431792466749326 0.004015804040207136 0.025231286629885233 1.0830310358623668e-07 6.965359097843157 -0.7537435084969208 HPIGVLLNAITELQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPIGVLLNAITELQK 15 0 Q9Y316;Q9Y316-3;Q9Y316-2 Q9Y316 MEMO1 Protein MEMO1 0 6131460.0 1127500.0 1451200.0 3552760.0 False True 1544367.2195418193 1387081.1855233437 2713671.259388979 1.0 0.8981550294332594 1.7571411935265417 20.558584406658593 -6.877319537479062 1.0946928619974876 0.9388676486853804 1.8149598759327576 0.971455807197725 0.06473959289253006 0.13002838244469378 0.2868896528016655 0.04566258510224541 0.109705200535605 1.326418170217328e-07 6.877319537479062 0.8760922272473772 HPIGVLLNAITELQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HPIGVLLNAITELQK 15 0 Q9Y316;Q9Y316-3;Q9Y316-2 Q9Y316 MEMO1 Protein MEMO1 0 16079700.0 8781500.0 2008800.0 5289400.0 False True 7302206.336411435 1997978.1956844188 6395389.084577629 1.0 0.27361294705160255 0.875815991762368 22.799901004505045 -10.41747035015443 8.369326555884081 1.0000056663022816 0.5747144694073766 0.3993952078152362 0.24584836351530326 2.5993403210790873e-05 1.8093403893877554e-06 0.23804482267607593 0.07934721813225974 3.824103604164718e-11 10.41747035015443 -0.425291196894905 HPK(ub)CLLESLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPKCLLESLR 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 37901500.0 7224500.0 12765000.0 17912000.0 True False 9471389.462157521 10860511.757580295 16058638.06403653 1.0 1.14666510135318 1.6954891495274311 23.175144655326257 -6.9464086148886235 0.5969813743215622 0.9937749868297806 1.8763280183322721 0.9988883761465154 0.009980199619692752 0.08496091426437491 0.0421851434335113 0.01027382878633006 0.04607686954767927 1.1313354221459003e-07 6.9464086148886235 0.8825530315024915 HPK(ub)CLLESLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPKCLLESLR 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 12292800.0 6592900.0 3254700.0 2445200.0 True False 6383611.998270998 4554318.683036277 1804728.7655723859 1.0 0.7134391445266121 0.2827127911378694 22.605941535235694 -7.086811830727767 0.3790666430622428 1.0325844390630803 4.625573522801061e-12 0.9998714128208128 0.0033428745941433942 0.0751830687618133 0.017558754241610887 0.006346876236536711 0.03558614178057096 8.188194859243147e-08 7.086811830727767 -1.0325844390584547 down HPK(ub)CLLESLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HPKCLLESLR 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 88067000.0 22014000.0 24645000.0 41408000.0 True False 33396847.438975733 20246907.197736103 33223690.65022887 1.0 0.6062520492310596 0.9948151756220923 24.99320858730558 -10.888605722206377 10.339661003520655 1.0140634104421256 0.8005336124265854 0.2600059289836162 0.15863023208643307 0.04951392025420578 0.0005334371115948625 0.14788153338248877 0.05119768725631437 1.292392049857166e-11 10.888605722206377 -0.21352979801554017 HPK(ub)CLLESLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPKCLLESLR 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 33518500.0 7224500.0 12544000.0 13750000.0 True False 9895592.884771517 11989764.602539172 10502533.19013905 1.0 1.2116267051558285 1.0613344053696432 23.238354716849148 -10.258583677585113 5.332577112094775 0.9999848157800105 1.1364805552627428 0.5237027807852268 0.06135657445764286 1.1078010760367013e-05 1.5402352603459254e-06 0.059414854839523176 0.01980274925455823 5.513359636227835e-11 10.258583677585113 0.1364957394827323 HPK(ub)CLLESLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HPKCLLESLR 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 23329000.0 6592900.0 3415100.0 13321000.0 True False 5482288.464991957 3396702.178455724 16106359.510655005 1.0 0.6195774264973317 2.937889827123249 22.38634681066997 -6.864782297731151 1.1612679757399236 0.79031723483943 3.060891036401538 0.9591965459938092 0.20505831997504914 0.1419599338433975 0.36108541267572947 0.13742673369287794 0.3227420380997273 1.365267343567678e-07 6.864782297731151 2.270573801562108 up HPK(ub)CLLESLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPKCLLESLR 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 63619000.0 22014000.0 19131000.0 22474000.0 True False 28497556.960814413 18066343.032499455 18383962.60271328 1.0 0.633961116643844 0.6451066183670467 24.76433490939803 -9.94062608642827 5.272891439152519 1.000000935192086 0.6395338675029834 0.9992834920885327 0.004550132033471056 5.0023287593486856e-08 1.004746968299851e-08 0.004405657815842658 0.0014685487978146731 1.1464996159078416e-10 9.94062608642827 -0.36046706768910264 HPLFPLLALLFEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPLFPLLALLFEK 13 0 P55347;P55347-2 P55347 PKNOX1 Homeobox protein PKNOX1 0 354612000.0 194800000.0 79295000.0 80517000.0 False True 252172440.08206838 74882163.5440929 65863732.174186386 1.0 0.29694824509658085 0.26118529111567995 27.9098353712854 -13.530934970065285 0.42879724277394016 9.99999999997016 0.2603756765363489 0.9998678449649626 0.003910484509840463 20.668466908907572 0.21915297854558677 172.2978496892938 0.008491217780188945 2.944862555548395e-14 13.530934970065285 -9.739624323433812 HPNETDGK(ub)STAIHAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPNETDGKSTAIHAK 15 1 Q8N5C7;Q8N5C7-2;H0YL61;H0YML0 Q8N5C7 DTWD1 DTW domain-containing protein 1 1 2967700.0 404330.0 767070.0 1796300.0 True False 391494.7654690526 1073365.0512172058 1325795.1421551106 1.0 2.7417098410784617 3.3864951950677202 18.5786334923431 -9.540802827508736 0.2887050874488683 3.4121114375445536e-16 3.664984154821882 0.9988059661656796 0.034831393737182643 0.9241951588610693 0.1172082216994369 1.1026381387540154 0.23704836803769566 2.878705068736128e-10 9.540802827508736 3.6649841548218816 HPNETDGK(ub)STAIHAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HPNETDGKSTAIHAK 15 1 Q8N5C7;Q8N5C7-2;H0YL61;H0YML0 Q8N5C7 DTWD1 DTW domain-containing protein 1 1 4332500.0 544870.0 995730.0 2791900.0 True False 826607.6253327304 818034.2018260015 2240079.7412667586 1.0 0.9896281824120872 2.709967429062937 19.656843146858403 -6.905543384397025 0.9255662741164697 0.9389407461359887 2.912325309672124 0.9891278900539944 0.08430621043299387 0.10743887071427448 0.15530538451843517 0.06753642772045855 0.1811442388530068 1.2429584627334663e-07 6.905543384397025 1.9733845635361353 up HPNETDGK(ub)STAIHAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPNETDGKSTAIHAK 15 1 Q8N5C7;Q8N5C7-2;H0YL61;H0YML0 Q8N5C7 DTWD1 DTW domain-containing protein 1 1 8653430.0 544870.0 747060.0 7361500.0 True False 705344.9559934117 705485.4542814811 6021782.535368604 1.0 1.000199190887913 8.53735818793443 19.427969468950852 -6.9068982062840645 0.9165966996733725 0.7431302137704154 9.449456896871519 0.9896975052411986 0.36064370817245084 0.10650510210131428 0.1501570813838157 0.29080836731529114 0.7865171311985695 1.2390869804742214e-07 6.9068982062840645 8.706326683101103 up HPNNLK(ub)VACEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPNNLKVACEK 11 1 O00764;F2Z2Y4;O00764-2;O00764-3 O00764;O00764-3 PDXK Pyridoxal kinase 1 5788470.0 778570.0 1469400.0 3540500.0 True False 1020712.8096826049 1250171.2476763385 3174163.022874123 1.0 1.224802153766528 3.1097513353057096 19.961145572337713 -6.929232028514967 0.7530690619925222 0.9705037033893394 3.489261059790969 0.996385133443468 0.05687840500791988 0.09303864438503116 0.07964814955123722 0.05158413349525171 0.17128145596896682 1.1769769874323735e-07 6.929232028514967 2.5187573564016295 up HPNNLK(ub)VACEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HPNNLKVACEK 11 1 O00764;F2Z2Y4;O00764-2;O00764-3 O00764;O00764-3 PDXK Pyridoxal kinase 1 12934120.0 985320.0 2944900.0 9003900.0 True False 1494802.47654091 2419359.5863912813 7224275.218450433 1.0 1.6185145692224625 4.832929655808419 20.511523428368427 -6.938946855435909 0.6692882923384899 0.9631790095167498 5.673546786334212 0.9980226957995962 0.07471139319233217 0.08825036798057811 0.05682209592257523 0.07215830231530146 0.2779665830307657 1.1509412208677591e-07 6.938946855435909 4.710367776817462 HPNNLK(ub)VACEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPNNLKVACEK 11 1 O00764;F2Z2Y4;O00764-2;O00764-3 O00764;O00764-3 PDXK Pyridoxal kinase 1 7130470.0 778570.0 1255200.0 5096700.0 True False 1066428.3690631264 1199741.1136086697 3892964.4298314047 1.0 1.1250086254388194 3.650469682508009 20.024355633860605 -6.917193945154576 0.8452894387796459 0.938444182033082 4.032534057073854 0.9933649730414036 0.09946108955770734 0.09985112184127663 0.11438183776238933 0.0844459566723233 0.24654661632680935 1.210057631116979e-07 6.917193945154576 3.094089875040772 up HPNNLK(ub)VACEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPNNLKVACEK 11 1 O00764;F2Z2Y4;O00764-2;O00764-3 O00764;O00764-3 PDXK Pyridoxal kinase 1 7967920.0 985320.0 1352100.0 5630500.0 True False 1275516.163560901 1276854.4464085766 4605806.773808722 1.0 1.0010492088504306 3.610935639537909 20.282649750460877 -6.906980238433166 0.9160351086012142 0.9112742470405873 3.9273295829956063 0.9897316803514852 0.12469595207031364 0.106449474033976 0.14984260709847727 0.1005898209718321 0.2721996737294846 1.2388529563889147e-07 6.906980238433166 3.016055335955019 up HPPAPAEPSSDLASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPPAPAEPSSDLASK 15 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5;A0A087WU26 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 3802570.0 387970.0 1463300.0 1951300.0 False True 508632.4271068247 1244981.3438987264 1749398.1941912924 1.0 2.447703444667029 3.4394153832112595 18.956263916281785 -8.127536889700327 0.19780037563723277 3.5276321379999273e-19 4.722999540368596 0.9998074207577844 0.013900466313540628 0.09185302851171676 0.03959845820209811 0.36253478145342666 0.4232598328069801 7.455265430655631e-09 8.127536889700327 4.722999540368596 HPPAPAEPSSDLASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPPAPAEPSSDLASK 15 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5;A0A087WU26 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 3376370.0 387970.0 1668200.0 1320200.0 False True 531412.9934950249 1594493.408000304 1008395.9503724802 1.0 3.0004787754878857 1.897574885665495 19.019473977804676 -10.464952792359636 5.995802865424853 0.9991024910447849 2.4490268305766896 0.6971099398560194 0.4502586275659366 0.005404453051351409 0.00048227606169516803 0.4361635825949616 0.14532034717075648 3.428050472958959e-11 10.464952792359636 1.4499243395319046 HPPAPAEPSSDLASK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HPPAPAEPSSDLASKLR 17 1 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5;A0A087WU26 Q9P2E9 RRBP1 Ribosome-binding protein 1 1 3678900.0 1762800.0 1916100.0 0.0 True False 1465846.3052811094 1905777.58898393 0.0 1.0 1.3001210168609414 0.0 20.48330241342834 -6.8829717486405855 1.3336842957341295 1.156577948768103 5.316585039536209e-19 0.9330594329268111 0.14380569496666015 0.14659407393802873 0.5240783364018885 0.08756133906916455 0.17782980050688743 1.3092670895709606e-07 6.8829717486405855 -1.156577948768103 down HPPAPAEPSSDLASK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPPAPAEPSSDLASKLR 17 1 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5;A0A087WU26 Q9P2E9 RRBP1 Ribosome-binding protein 1 1 12909200.0 3482900.0 3260500.0 6165800.0 True False 4508682.708222972 3079050.30879015 5043687.666450545 1.0 0.6829157224070244 1.118661035351152 22.104274555374175 -6.711571316873282 1.7896044932750825 0.8053769797141553 1.117685294979095 0.47255572202310914 0.13358523095208147 0.37192928934062225 2.322945236915878 0.05938035452533709 0.15056721512378068 1.9428026318547215e-07 6.711571316873282 0.31230831526493963 HPPSVK(ub)YAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPPSVKYAR 9 1 Q96G04-2;Q96G04;Q9NVL1-3 Q96G04-2 EEF2KMT Protein-lysine N-methyltransferase EEF2KMT 1 3938750.0 810950.0 1209300.0 1918500.0 True False 1063163.3032509722 1028877.153814479 1719992.0235514757 1.0 0.9677508155787056 1.6178060494488788 20.019931783028024 -6.895230124957419 0.9909286564664188 0.9693223707405547 1.6797992626459863 0.9840395888481134 0.037790147254952604 0.11500334179066446 0.1978820280801351 0.02883909293411105 0.07339079699900916 1.2728284530320167e-07 6.895230124957419 0.7104768919054316 HPPSVK(ub)YAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPPSVKYAR 9 1 Q96G04-2;Q96G04;Q9NVL1-3 Q96G04-2 EEF2KMT Protein-lysine N-methyltransferase EEF2KMT 1 4437250.0 810950.0 1096200.0 2530100.0 True False 1110780.1300997257 1047766.2593513569 1932542.4890451522 1.0 0.9432706176129462 1.7398064987637551 20.083141844550916 -6.889797213714344 1.0236043385481062 0.9569927342580155 1.8080386238192705 0.980767356588817 0.050321971043532976 0.11930692676171553 0.2228211960502253 0.03746914839541811 0.09334127220247757 1.2888512179646642e-07 6.889797213714344 0.851045889561255 HPPSVK(ub)YAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HPPSVKYAR 9 1 Q96G04-2;Q96G04;Q9NVL1-3 Q96G04-2 EEF2KMT Protein-lysine N-methyltransferase EEF2KMT 1 4401600.0 1029900.0 1316500.0 2055200.0 True False 856407.482306 1309407.753195211 2484932.817828856 1.0 1.528954125516796 2.9015776591977196 19.70793787482932 -6.954657724628429 0.5051298782317903 0.9736913521288707 3.5165618270126515 0.9995179210773081 0.01759532968220746 0.08166762288224089 0.02862626009233687 0.020441024693542125 0.11325354351047298 1.1100493206476313e-07 6.954657724628429 2.542870474883781 HPQIQK(ub)ESQYIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HPQIQKESQYIK 12 1 Q7Z5R6 Q7Z5R6 APBB1IP Amyloid beta A4 precursor protein-binding family B member 1-interacting protein 1 7258100.0 1293700.0 2364100.0 3600300.0 True False 1962637.4821387737 1942207.884202393 2888699.1269324506 1.0 0.9895907430066414 1.4718454901740214 20.904362287202407 -6.901969835255967 0.948750121574298 0.9810184180908895 1.5245373612807962 0.9875203375356382 0.025126771247753983 0.10996977050767877 0.16936413340491402 0.01978749698038868 0.052010496059587887 1.253228217252898e-07 6.901969835255967 0.5435189431899067 HPQIQK(ub)ESQYIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HPQIQKESQYIK 12 1 Q7Z5R6 Q7Z5R6 APBB1IP Amyloid beta A4 precursor protein-binding family B member 1-interacting protein 1 3067560.0 602660.0 1221700.0 1243200.0 True False 501138.49236482574 1215118.4596115367 1503147.3720926603 1.0 2.4247158781946805 2.9994650081646057 18.934849829628092 -9.586035352283085 0.2569221602952178 4.528647610442474e-14 3.326237251218475 0.9990379637173485 0.02606964632697283 0.9871303338500244 0.1052753305113264 1.0346541366507072 0.24436073818508494 2.593968200258769e-10 9.586035352283085 3.3262372512184295 HPQIQK(ub)ESQYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPQIQKESQYIK 12 1 Q7Z5R6 Q7Z5R6 APBB1IP Amyloid beta A4 precursor protein-binding family B member 1-interacting protein 1 7459600.0 1293700.0 2222200.0 3943700.0 True False 1674720.1526394864 2098532.6165292086 3225987.0657791407 1.0 1.2530646467839786 1.9262842575189292 20.675488609294856 -6.954116948669093 0.5116568656234652 0.9877768300924252 2.221190669640665 0.9994860046772394 0.008862414236021382 0.08187354295198679 0.029437892150000637 0.01017881381002968 0.05556877340074963 1.1114323957282063e-07 6.954116948669093 1.23341383954824 HPQLLYESK(ub)LYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPQLLYESKLYK 12 1 U3KPX3;A0A590UJ43;P48729;P48729-2;A0A590UJQ7;E5RG27;D6RGE5;A0A590UK94;A0A5F9W493;P48729-3 U3KPX3 CSNK1A1 Casein kinase I isoform alpha 1 7002200.0 2158200.0 2871900.0 1972100.0 True False 2829421.1000385303 2443423.714578521 1768046.0097189818 1.0 0.8635772577454968 0.6248790643764214 21.432075476962133 -6.962573029025822 0.39751421801221143 1.0134867634582727 0.4662887133379834 0.9998540419060721 0.0018729352198819972 0.07879449852858757 0.017826883149409008 0.0030727029716692217 0.020017849627862537 1.0900011872286591e-07 6.962573029025822 -0.5471980501202893 HPQLLYESK(ub)LYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPQLLYESKLYK 12 1 U3KPX3;A0A590UJ43;P48729;P48729-2;A0A590UJQ7;E5RG27;D6RGE5;A0A590UK94;A0A5F9W493;P48729-3 U3KPX3 CSNK1A1 Casein kinase I isoform alpha 1 7561100.0 1952000.0 2364900.0 3244200.0 True False 1890034.8284707796 3309216.9027905767 2394446.6960861823 1.0 1.7508761494453795 1.2668796680448056 20.849981389166878 -10.256504165058882 4.618291231879058 0.9998125293425782 1.5088779087473987 0.5957874309644814 0.1975907361301888 0.00038154061327221804 6.142422963820388e-05 0.19138611023071134 0.06377213586531168 5.5398223100054855e-11 10.256504165058882 0.5090653794048204 HPQLLYESK(ub)LYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPQLLYESKLYK 12 1 U3KPX3;A0A590UJ43;P48729;P48729-2;A0A590UJQ7;E5RG27;D6RGE5;A0A590UK94;A0A5F9W493;P48729-3 U3KPX3 CSNK1A1 Casein kinase I isoform alpha 1 6193300.0 2158200.0 1646000.0 2389100.0 True False 2956144.8631620025 1573274.277405887 1824843.7850589978 1.0 0.5322047295486914 0.6173052639602638 21.495285538485025 -10.833936946103595 7.367998697850105 1.025414809240711 0.5747549967544786 0.9708395076113022 0.03474214769108558 0.012962672199105057 0.0002921578201078651 0.030063665435009945 0.011212979951587732 1.4657606348415594e-11 10.833936946103595 -0.4506598124862323 HPQLLYESK(ub)LYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HPQLLYESKLYK 12 1 U3KPX3;A0A590UJ43;P48729;P48729-2;A0A590UJQ7;E5RG27;D6RGE5;A0A590UK94;A0A5F9W493;P48729-3 U3KPX3 CSNK1A1 Casein kinase I isoform alpha 1 8086400.0 1952000.0 3614800.0 2519600.0 True False 1623174.488262269 3595326.354918379 3046436.7106858636 1.0 2.214996835471119 1.8768387087868197 20.630386664601154 -10.088436717309605 4.609801392636897 0.9999391373522795 2.0459177720231305 0.9273012904425237 0.13805247725396572 47993217.83233378 4.499429804345326 33453.91171898955 0.04725903492513372 8.157616461855517e-11 10.088436717309605 1.045978634670851 HPQLLYESK(ub)LYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPQLLYESKLYK 12 1 U3KPX3;A0A590UJ43;P48729;P48729-2;A0A590UJQ7;E5RG27;D6RGE5;A0A590UK94;A0A5F9W493;P48729-3 U3KPX3 CSNK1A1 Casein kinase I isoform alpha 1 17687400.0 3613400.0 7912500.0 6161500.0 True False 4677617.530762555 7472162.4193534935 5040170.222328823 1.0 1.5974291121949353 1.0775079811852775 22.157342472692545 -10.25939344725817 4.3766615436476535 0.9998064250934214 1.33746854669538 0.35968592808321 0.21225691292854684 0.00040114639404112255 6.788046397125575e-05 0.20563395678860075 0.06850562407165044 5.5030892045699636e-11 10.25939344725817 0.3376621216019585 HPQPFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPQPFLR 7 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 3666700.0 1103900.0 1024800.0 1538000.0 False True 1068857.2987443092 1434007.9842614005 1135151.660989011 1.0 1.3416271619664004 1.0620235856765765 20.027637823564742 -10.126299999620207 4.9070147571234575 0.9999895836190544 1.2018253738223665 0.4099292509286131 0.11414768203093777 1.3008480036613344e-05 2.3160578003286475e-06 0.11052871989681966 0.036841005959067225 7.47652862444545e-11 10.126299999620207 0.2018357902033121 HPQPFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HPQPFLR 7 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 21756000.0 5149500.0 11407000.0 5199500.0 False True 7812167.978877342 9371331.726702204 4171816.5459781936 1.0 1.1995814416741362 0.5340152128395106 22.897291540014297 -6.826327632278543 1.3443491701615908 1.1069415446294553 0.5174254724535968 0.8983049718212835 0.0889330195036029 0.18538854029792567 0.656561616833295 0.05196091789280581 0.11960411011196082 1.491668668367875e-07 6.826327632278543 -0.5895160721758584 HPQPFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPQPFLR 7 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 5692100.0 1229500.0 2358700.0 2103900.0 False True 1684079.3759881754 2254484.834822154 1607002.151180624 1.0 1.338704616282875 0.9542318337802074 20.683528708111933 -6.67408837426727 1.9227088913302501 1.2154284385420115 0.9557496239206338 0.2973296540796835 0.1437401476305295 0.45181396082965414 3.2238488179579723 0.06010020794186017 0.1597315435211401 2.1179301153420548e-07 6.67408837426727 -0.25967881462137776 HPQPFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPQPFLR 7 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 15646700.0 5149500.0 5088900.0 5408300.0 False True 6666129.26182039 4805698.241497376 4424044.893844192 1.0 0.7209128495334688 0.6636602322103894 22.668417862106747 -13.999999999999998 0.2226661682986587 2.7040870398979555 0.6338072316679122 0.9995007028952821 0.0032831066391069974 13.073536866138745 0.14946595603724822 9.80991201133154 0.03113705888361161 1.0000000000000041e-14 13.999999999999998 -2.070279808230043 HPQPGAVELAAK(ub)HCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPQPGAVELAAKHCR 15 1 F8VPD4;P27708;H7C2E4 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 2837490.0 790260.0 1136700.0 910530.0 True False 1036038.5128887274 967108.7908218972 816317.090020498 1.0 0.9334679925414767 0.7879215684216289 19.98264620296722 -6.958253957117659 0.4593799981044716 1.0042687858361197 0.7112596132738003 0.9996998552645 0.0015342814398849893 0.0803308343862079 0.023481200870220306 0.001974610437217626 0.012024420305400478 1.1008953640517686e-07 6.958253957117659 -0.2930091725623194 HPQPGAVELAAK(ub)HCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPQPGAVELAAKHCR 15 1 F8VPD4;P27708;H7C2E4 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 2704380.0 790260.0 964830.0 949290.0 True False 1082440.4779734996 922200.6203338546 725087.2532412447 1.0 0.8519642780362026 0.6698633947972116 20.045856264490112 -6.9683436309411775 0.29507877054486614 1.0334875876213752 0.482673707213086 0.9999664248942556 0.0007823196284496713 0.07684391331977611 0.010943713967914458 0.003097350315252745 0.01641908570815557 1.0756138087281214e-07 6.9683436309411775 -0.5508138804082892 HPQPGAVELAAK(ub)HCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPQPGAVELAAKHCR 15 1 F8VPD4;P27708;H7C2E4 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 12130360.0 2603070.0 2676400.0 6850890.0 True False 3369725.429180854 2527455.987255319 5604098.316067567 1.0 0.7500480500186384 1.6630726846578316 21.684199612334556 -6.833729962221855 1.3110450537823155 0.8667434979005685 1.6895874916834699 0.913148046976525 0.11353558437714847 0.1762549907004351 0.5911485025465419 0.06796408861522395 0.15642179984030352 1.4664593799264893e-07 6.833729962221855 0.8228439937829014 HPSK(ub)PDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPSKPDPSGECNPDLR 16 1 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 14140600.0 5337100.0 4766600.0 4036900.0 True False 6996989.784549926 4055441.860061278 3619200.3126791557 1.0 0.5795980821661497 0.5172510499687626 22.738302954675582 -13.999999999999998 0.2687480649095257 4.223114083709894 0.4963034188507941 0.9995806432009875 0.004390338447834412 14.821962911618469 0.16409640807796633 26.081409019743802 0.026056943929482143 1.0000000000000041e-14 13.999999999999998 -3.7268106648590997 HPSK(ub)PDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPSKPDPSGECNPDLR 16 1 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 7575810.0 4045710.0 2204700.0 1325400.0 True False 3917281.1505596866 3085048.207358616 978237.9788522989 1.0 0.7875483246633538 0.24972370918858655 21.90142124623729 -6.955192541263798 0.498591281724231 1.0109037249291908 0.0032269614534145884 0.9995482813215142 0.006710931170957679 0.0814652627114912 0.02783362507849795 0.00789119691130347 0.04436370372012343 1.108683179756904e-07 6.955192541263798 -1.0076767634757762 down HPSK(ub)PDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HPSKPDPSGECNPDLR 16 1 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 40086000.0 11112000.0 11872000.0 17102000.0 True False 16857716.396016106 9753348.843640633 13721782.203927126 1.0 0.5785688057930307 0.8139763347288201 24.006905781317275 -10.136225132174662 5.3115583322889774 1.0000078432023296 0.6962725702607662 0.6893981462245505 0.09610472125091653 8.926348570355535e-06 1.4515290733366688e-06 0.09305539836550726 0.03101766540797825 7.307601694466374e-11 10.136225132174662 -0.30373527294156344 HPSK(ub)PDPSGECNPDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPSKPDPSGECNPDLR 16 1 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 15066700.0 5337100.0 4388000.0 5341600.0 True False 7310370.099704354 4194123.650824447 4080024.09370522 1.0 0.5737224782906772 0.5581145739625719 22.801513016198474 HPSK(ub)PDPSGECNPDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HPSKPDPSGECNPDLR 16 1 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 10595410.0 4045710.0 2661400.0 3888300.0 True False 3364187.1203419752 2647062.5099534583 4701325.552532085 1.0 0.7868356947054658 1.3974625620866736 21.681826521671567 -6.812385950146451 1.404350760341562 0.8841501486387835 1.408752122734572 0.8660001534675524 0.09262920254921608 0.20356180317315736 0.7907673924676956 0.05185553436944334 0.11983544060692498 1.540330978487402e-07 6.812385950146451 0.5246019740957886 HPSK(ub)PDPSGECNPDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPSKPDPSGECNPDLR 16 1 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 41295800.0 11112000.0 9915800.0 20268000.0 True False 14384703.050266644 9363977.013311269 16579431.967241839 1.0 0.6509676967671357 1.1525738076973728 23.778032103409725 -6.719554878376259 1.7609160379143716 0.7875641359514816 1.1517769487519314 0.5105649787326231 0.14688024582185213 0.3561070800097912 2.1577795657150225 0.06623659866747392 0.1663658065325501 1.9074146837768734e-07 6.719554878376259 0.3642128128004498 HPSKPDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPSKPDPSGECNPDLR 16 1 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 32981600.0 4296200.0 16098100.0 12587300.0 False True 5632359.804459987 13696326.229902314 11284886.941907478 1.0 2.4317207538937535 2.0035806187260152 22.4253080679886 -10.567682104554079 5.401613272232209 0.9943725889906722 2.217650686309886 0.9151449668816385 0.1747874782612031 0.011841623953388098 0.0009477429077322029 0.1691854556397709 0.056412416035934915 2.7059383356703516e-11 10.567682104554079 1.223278097319214 HPSKPDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPSKPDPSGECNPDLR 16 1 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 10189200.0 4497000.0 1516100.0 4176100.0 False True 4354245.196533352 2121486.6363570513 3082254.1296854434 1.0 0.4872225932627957 0.7078733490110733 22.05399122027301 -10.291329742206962 5.697456217981865 1.000036905947054 0.5975479711369313 0.8160289704675252 0.09008029382380825 4.2232697766521684e-05 5.2530903686548636e-06 0.0872278473796114 0.029073289816754562 5.112934836992359e-11 10.291329742206962 -0.4024889348101227 HPSKPDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HPSKPDPSGECNPDLR 16 1 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 89619000.0 13116300.0 71141800.0 5360900.0 False True 19898386.029973533 58445989.95657956 4301315.765234061 1.0 2.937222640496602 0.216164052639991 24.246148081865766 -6.715536689660264 1.7755923125917583 2.184160104948385 0.22148623034960396 0.49132756672062927 0.815664806615926 0.3640375346993944 2.2405237973700425 0.3651227470151239 0.9213663850159374 1.925144399958778e-07 6.715536689660264 -1.962673874598781 HPSKPDPSGECNPDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPSKPDPSGECNPDLR 16 1 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 31408120.0 4296200.0 15296300.0 11815620.0 False True 5884621.240439536 14620458.887900172 9025013.906332428 1.0 2.484519953030679 1.533660967729221 22.48851812951149 -10.278823975668985 5.127882151823096 0.999797779845908 2.009090460380194 0.6002627139874089 0.3881865552223736 0.0008976129011196004 0.000126238928828299 0.3759331539078304 0.1252866719663678 5.262305101873889e-11 10.278823975668985 1.0092926805342861 HPSKPDPSGECNPDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HPSKPDPSGECNPDLR 16 1 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 42953570.0 13116300.0 17065070.0 12772200.0 False True 16979308.91092623 16115383.85309784 10447790.653838862 1.0 0.9491189504613787 0.6153248467678022 24.017274403958215 -6.933976369694566 0.7133978465146039 1.004404502225525 0.5393011299196507 0.9972636482942131 0.008924844063697061 0.09062515059464028 0.06794659248623766 0.00833262907529066 0.029570129792524647 1.1641893721495366e-07 6.933976369694566 -0.4651033723058743 HPSLQVLICK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPSLQVLICK 10 0 P46100-5;P46100-3;P46100-4;P46100;A0A096LNN3;A0A096LNW1;A0A096LNL9;P46100-6;A0A096LNL7;A0A096LNL6 P46100-5 ATRX Transcriptional regulator ATRX 0 10049600.0 2721600.0 3125400.0 4202600.0 False True 3568043.9560118946 2659102.5027137785 3767755.2661857903 1.0 0.7452549731718927 1.055972211283271 21.766701957768984 -6.688834557755561 1.8706590634442422 0.8401141952633634 1.054879882234781 0.3649009473611349 0.10776529640194174 0.4191947658878363 2.843201525592569 0.046102496310608226 0.12022623331184348 2.0472243677690756e-07 6.688834557755561 0.2147656869714175 HPSLQVLICK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPSLQVLICK 10 0 P46100-5;P46100-3;P46100-4;P46100;A0A096LNN3;A0A096LNW1;A0A096LNL9;P46100-6;A0A096LNL7;A0A096LNL6 P46100-5 ATRX Transcriptional regulator ATRX 0 5643900.0 2721600.0 2922300.0 0.0 False True 3727849.0684745223 2793183.123246188 0.0 1.0 0.7492747350925314 0.0 21.829912019291875 -7.335520788865213 0.7966007107796376 0.989261133828639 1.8068142998756227e-23 0.9879466042605508 0.04664051476234554 0.10750820052477919 0.13770477727341435 0.039967442502446555 0.07103021719854795 4.618268845762603e-08 7.335520788865213 -0.989261133828639 down HPTCK(ub)IQTLMFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPTCKIQTLMFR 12 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 86252000.0 21371000.0 37243000.0 27638000.0 True False 28017587.957058407 31686489.57207694 24778284.882416327 1.0 1.130949945464318 0.8843832281491594 24.739829423257344 -6.762410606548619 1.6031582278941057 1.0758365757239916 0.8833669674789111 0.700763636040284 0.05509925755338578 0.2789166603685372 1.413315836216855 0.027109160602103957 0.06499967429495009 1.728181665950918e-07 6.762410606548619 -0.19246960824508053 HPTCK(ub)IQTLMFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPTCKIQTLMFR 12 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 72156000.0 17642000.0 36311000.0 18203000.0 True False 17081964.366742544 50810171.659363516 13435088.221705422 1.0 2.9744923106318826 0.7865072150520728 24.025970553643162 -6.668978463123432 1.9409326548785115 2.261403646018973 0.7953746501972901 0.27457499125677065 0.8389167872165071 0.463454688469261 3.3649978910571297 0.3480809742458059 0.9312465397316086 2.1429968707519478e-07 6.668978463123432 -1.466028995821683 HPTCK(ub)IQTLMFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPTCKIQTLMFR 12 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 94626000.0 21371000.0 28804000.0 44451000.0 True False 29272436.22955944 27531344.03790958 33952589.2970816 1.0 0.9405211039492607 1.1598825950399072 24.803039484780236 -6.834488204900668 1.3077574851870841 0.9683036261917272 1.1663445091664129 0.914552501805113 0.027076487087866863 0.17533708765806616 0.584857009620324 0.016248328750870407 0.037395363998949833 1.463901295427901e-07 6.834488204900668 0.1980408829746857 HPTCK(ub)IQTLMFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HPTCKIQTLMFR 12 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 62235000.0 17642000.0 0.0 44593000.0 True False 14670104.673116243 0.0 53917190.12526373 1.0 0.0 3.6753105261798087 23.80637582907744 -6.834213065070847 1.3089441244408593 0.4670281488366797 3.783024084218138 0.9140499567499476 0.45486559068851873 0.17566653596006587 0.587116853797977 0.2727182040550764 0.6276640958476106 1.4648290188585362e-07 6.834213065070847 3.315995935381458 HPVSLEQYLMEGSYNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HPVSLEQYLMEGSYNK 16 0 R4GMR5;P48556;K7EJR3;K7EJC1 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 6875700.0 1404600.0 1952300.0 3518800.0 False True 1841444.2021657513 1661024.4500057963 3154708.330713029 1.0 0.9020226885247131 1.71317074229169 20.812406251938768 -6.876717479291358 1.0979972685587194 0.9415576185211069 1.7671448678543786 0.9709373255650491 0.061628582172535896 0.13057483112305693 0.29022600691203126 0.04335841424025603 0.10402664127471038 1.3282582458833272e-07 6.876717479291358 0.8255872493332718 HPVSLEQYLMEGSYNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HPVSLEQYLMEGSYNK 16 0 R4GMR5;P48556;K7EJR3;K7EJC1 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 4050230.0 743660.0 912470.0 2394100.0 False True 720052.9203589039 1276824.0294681897 1767013.3885395261 1.0 1.773236373837312 2.4540048912776773 19.457743415899657 -6.972623504327184 0.18508443627799304 0.5078994470186116 3.737845593535092 0.9999962735991662 0.001146626737460621 0.07546024179553742 0.005870835175328131 0.025072738383978506 0.07525248443897012 1.0650659379731592e-07 6.972623504327184 3.2299461465164803 HPVSLEQYLMEGSYNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HPVSLEQYLMEGSYNK 16 0 R4GMR5;P48556;K7EJR3;K7EJC1 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 7651040.0 1404600.0 3653640.0 2592800.0 False True 1923918.5778877554 3492210.1038282234 1980434.0403921856 1.0 1.8151548324161797 1.0293751841444754 20.87561631346166 -10.212451959744335 3.9699430432300833 0.9997179993820274 1.422265007771301 0.27799989167884553 0.32079319895613906 173810125.5861824 332724817.5057312 686777.9850793474 0.1268046663266156 6.131236101562335e-11 10.212451959744335 0.4225470083892736 HQACLLLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQACLLLQK 9 0 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 0 16021400.0 5454100.0 4030400.0 6536900.0 False True 7150377.917579525 3429080.0303761503 5860524.2943725 1.0 0.4795662648747003 0.8196104264592977 22.76958806372001 -9.877402026557704 5.396038714526281 1.0000003068996666 0.6495883456639857 0.5860714449504763 0.1388224476597213 5.126259052009907e-07 1.0653027598107859e-07 0.13441437513268156 0.04480475232062207 1.3261662567647512e-10 9.877402026557704 -0.35041196123568086 HQACLLLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQACLLLQK 9 0 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 0 9994800.0 2970000.0 3998300.0 3026500.0 False True 4505707.136084215 3284772.1261395123 2428310.948437924 1.0 0.7290247738991347 0.5389411417778701 22.10332211302401 -7.741473883081173 0.11894870021104083 1.4095274339377817 1.1347924514203625e-09 0.9999887137312665 0.0006355573248395485 0.13440983582055574 0.014835049141694513 0.0707079522887703 0.09486628148491665 1.813535732152564e-08 7.741473883081173 -1.4095274328029892 HQACLLLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQACLLLQK 9 0 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 0 10618800.0 5454100.0 2118300.0 3046400.0 False True 7470628.161510454 2024706.501718646 2326903.062577428 1.0 0.2710222564884396 0.31147354844481534 22.832798125242903 -9.964623770904304 5.908950777397725 1.0000005401410488 0.2912479024664273 0.9975628757307025 0.016514170788957134 1.175118385224467e-07 2.0584890505945875e-08 0.01598978938002653 0.005329925703400546 1.0848663262201829e-10 9.964623770904304 -0.7087526376746215 HQACLLLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HQACLLLQK 9 0 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 0 8702500.0 2970000.0 2904900.0 2827600.0 False True 3844723.547452475 2743239.761387676 2313005.813626063 1.0 0.7135076755272443 0.6016052350912636 21.87444843511646 -13.99999999997726 0.1299877094866484 2.3614751554973297 0.4448691068883958 0.9996456712736675 0.003158017750701533 11.936752742316932 0.1121176946376438 4.152231261901754 0.13938963381822225 1.0000000000523587e-14 13.99999999997726 -1.9166060486089338 HQADACHAYQIIHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQADACHAYQIIHR 14 0 Q99538;Q99538-2;Q99538-3;G3V4E4;G3V2T4;G3V4P5;G3V3Z4 Q99538 LGMN Legumain 0 59113790.0 13147000.0 25014000.0 20952790.0 False True 17235844.315729108 21282008.703808315 18784796.28415386 1.0 1.234752897157858 1.0898680644853127 24.038908636562216 -10.540108625914216 4.186087646387257 0.998071586778283 1.162310480821305 0.6259370767895275 0.059148985254270064 0.0010768102189865599 0.00011830037087105823 0.057931381488493514 0.019090252902688856 2.8833102381876208e-11 10.540108625914216 0.16423889404302194 HQADACHAYQIIHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQADACHAYQIIHR 14 0 Q99538;Q99538-2;Q99538-3;G3V4E4;G3V2T4;G3V4P5;G3V3Z4 Q99538 LGMN Legumain 0 21031200.0 7803600.0 3942700.0 9284900.0 False True 7555878.989474671 5517040.670908886 6852906.148970652 1.0 0.7301653028845639 0.9069634596473476 22.84916816587804 -10.414354006789837 6.380519705291994 1.0000332656045245 0.8185643816299042 0.5840608903003994 0.07217754525556853 3.416144020586639e-05 3.1356331497572813e-06 0.06989840391921834 0.023295202562079086 3.851642704287173e-11 10.414354006789837 -0.18146888397462035 HQADACHAYQIIHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQADACHAYQIIHR 14 0 Q99538;Q99538-2;Q99538-3;G3V4E4;G3V2T4;G3V4P5;G3V3Z4 Q99538 LGMN Legumain 0 112260000.0 25426000.0 70532000.0 16302000.0 False True 38573100.88958831 57945013.53096873 13079902.554579582 1.0 1.502212998037949 0.3390938828594442 25.201091793020026 -6.7893735729644975 1.4989215933354387 1.2809188788819648 0.32695226758749657 0.7992496864227299 0.2134125397557239 0.23629421425733757 1.0488332634817665 0.11207337782045851 0.262501683342971 1.6241510866807676e-07 6.7893735729644975 -0.9539666112944682 down HQADACHAYQIIHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQADACHAYQIIHR 14 0 Q99538;Q99538-2;Q99538-3;G3V4E4;G3V2T4;G3V4P5;G3V3Z4 Q99538 LGMN Legumain 0 56665000.0 13147000.0 22229000.0 21289000.0 False True 18007801.184316028 21246849.27852704 16260976.660717865 1.0 1.1798691612073147 0.902996234480889 24.102118698085107 -6.731345289241633 1.71814361615562 1.1080804663382262 0.9031143585779614 0.5655754361885375 0.07560504499337366 0.33372007435100887 1.9305664190159384 0.03486136535483802 0.08638066469675426 1.856327980075614e-07 6.731345289241633 -0.2049661077602648 HQADACHAYQIIHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HQADACHAYQIIHR 14 0 Q99538;Q99538-2;Q99538-3;G3V4E4;G3V2T4;G3V4P5;G3V3Z4 Q99538 LGMN Legumain 0 18133900.0 7803600.0 4058100.0 6272200.0 False True 6489039.158096017 4036238.2098302217 7583688.020623849 1.0 0.6220086073597552 1.1686919797921236 22.629573441312317 -6.720716337877152 1.7568447200776252 0.7702063010267052 1.1678668339040736 0.5158139390135328 0.15904678680480427 0.3539449073263522 2.1354148166227165 0.07187268168738553 0.180268188166548 1.9023203865426173e-07 6.720716337877152 0.39766053287736847 HQADACHAYQIIHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HQADACHAYQIIHR 14 0 Q99538;Q99538-2;Q99538-3;G3V4E4;G3V2T4;G3V4P5;G3V3Z4 Q99538 LGMN Legumain 0 61721000.0 25426000.0 18926000.0 17369000.0 False True 32914458.22138945 17872751.46270892 14208020.220989924 1.0 0.5430060960594612 0.43166501861959394 24.972218115112476 -13.999999999999998 0.1983335644564401 3.524437068247605 0.3581560852606124 0.9994869363118678 0.005570078828498951 12.498440222520358 0.14121840899051716 12.231266747008663 0.0717873191280914 1.0000000000000041e-14 13.999999999999998 -3.1662809829869927 HQAFEAELSANQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQAFEAELSANQSR 14 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 9163400.0 1933300.0 4208900.0 3021200.0 False True 2534575.022103831 3580948.526163698 2708595.2053967835 1.0 1.4128398232186956 1.068658525305164 21.273312436907236 -10.243532264840356 6.089811254705768 0.9999940458595024 1.2407491742619303 0.3948085758206781 0.14051142648283502 1.1359010328136166e-05 1.4110656847617058e-06 0.13605296811798406 0.04534986789332202 5.707786699992374e-11 10.243532264840356 0.24075512840242796 HQAFEAELSANQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQAFEAELSANQSR 14 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 7481700.0 1933300.0 3019900.0 2528500.0 False True 2648093.2554680277 2886470.832526152 1931320.3760921191 1.0 1.0900185733889471 0.7293249103309146 21.336522498430128 -6.840615225273086 1.2794475656635107 1.047886046583188 0.717309822694636 0.9255192293347457 0.041833425188557954 0.16808237905654247 0.5341989970345117 0.02563495441413969 0.05907092500231346 1.4433935980738438e-07 6.840615225273086 -0.3305762238885521 HQAQIDHYLGLANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQAQIDHYLGLANK 14 0 F8W914;Q9NQC3-2;Q9NQC3-5;Q9NQC3;H7C106;Q9NQC3-3;Q9NQC3-4;Q9NQC3-6 F8W914 RTN4 Reticulon;Reticulon-4 0 37456200.0 10796000.0 8639200.0 18021000.0 False True 14153660.548612716 7350265.035337844 16156359.78963834 1.0 0.519319013628477 1.1414969105799222 23.75467188845981 -6.700418581857969 1.8295719344652364 0.7016371167419341 1.1396493534826713 0.4194997752376729 0.2028858925133222 0.3946393411589237 2.568531471462611 0.08846209139610757 0.22736720434194685 1.9933401670048498e-07 6.700418581857969 0.4380122367407372 HQAQIDHYLGLANK(ub)NVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQAQIDHYLGLANKNVK 17 1 F8W914;Q9NQC3-2;Q9NQC3-5;Q9NQC3;H7C106;Q9NQC3-3;Q9NQC3-4;Q9NQC3-6 F8W914 RTN4 Reticulon;Reticulon-4 1 10624400.0 3128100.0 3317700.0 4178600.0 True False 4100969.3925634907 2822712.0922933123 3746238.5559615316 1.0 0.6883036233852143 0.9135007354004613 21.967533545527306 -9.844444936094956 5.903913742239571 1.0000000299756344 0.800902180603452 0.5103291437143723 0.0919363359986721 3.631287250916498e-08 7.077235086743414e-09 0.08901698782263594 0.02967232485269559 1.430721369520195e-10 9.844444936094956 -0.19909784937218244 HQAQIDHYLGLANK(ub)NVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQAQIDHYLGLANKNVK 17 1 F8W914;Q9NQC3-2;Q9NQC3-5;Q9NQC3;H7C106;Q9NQC3-3;Q9NQC3-4;Q9NQC3-6 F8W914 RTN4 Reticulon;Reticulon-4 1 11018500.0 1260900.0 2510100.0 7247500.0 True False 1220873.4196817647 3512396.019998572 5349162.32966051 1.0 2.876953469028853 4.381422548338249 20.21948219858976 -7.578918857516911 0.212697554285824 4.160711002487912e-19 6.3803201431455285 0.9999128442347043 0.012913631211055716 0.13682737147978583 0.023696245866083102 0.20335589393322728 0.40437593561556795 2.6368239973344944e-08 7.578918857516911 6.3803201431455285 HQAQIDHYLGLANK(ub)NVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HQAQIDHYLGLANKNVK 17 1 F8W914;Q9NQC3-2;Q9NQC3-5;Q9NQC3;H7C106;Q9NQC3-3;Q9NQC3-4;Q9NQC3-6 F8W914 RTN4 Reticulon;Reticulon-4 1 10106200.0 1260900.0 3796400.0 5048900.0 True False 1048494.2173411341 3775948.0396735957 6104601.646523993 1.0 3.601305545822641 5.822255903332105 19.999887474024035 -7.538649155341026 0.245921182128407 1.231885189593132e-25 8.217145900672783 0.9998495404224474 0.024173212969839906 0.13563832290481245 0.02703962581264353 0.22505447456720096 0.5193544550649009 2.8930160607017813e-08 7.538649155341026 8.217145900672783 HQCITAMK(ub)EYESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQCITAMKEYESK 13 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 1743510.0 680020.0 619950.0 443540.0 True False 891512.8053230476 527455.8765461731 397646.7355361078 1.0 0.5916413913483215 0.44603592137077264 19.765895994713755 -13.999999999999998 0.1436195266209828 2.957792954289712 0.27346399303049723 0.9995889060087478 0.004754213870960564 11.939431320363138 0.11898637455642352 6.538762620520426 0.1546827588685908 1.0000000000000041e-14 13.999999999999998 -2.6843289612592147 HQCSIDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQCSIDLK 8 0 Q5TDH0;Q5TDH0-3;Q8WTU0 Q5TDH0 DDI2;DDI1 Protein DDI1 homolog 2;Protein DDI1 homolog 1 0 3103310.0 764760.0 1445600.0 892950.0 False True 1002607.765946375 1229922.1149046645 800556.0997812308 1.0 1.2267231081575798 0.7984738668222614 19.935325883351535 -6.762862628977092 1.6015746561243887 1.1312251079115119 0.7966782381147174 0.7025655641525983 0.0954040981384141 0.27814732298863976 1.4067470288384296 0.046985034809346474 0.11260103256837667 1.726383875477572e-07 6.762862628977092 -0.3345468697967945 HQCSIDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQCSIDLK 8 0 Q5TDH0;Q5TDH0-3;Q8WTU0 Q5TDH0 DDI2;DDI1 Protein DDI1 homolog 2;Protein DDI1 homolog 1 0 3121860.0 764760.0 1057900.0 1299200.0 False True 1047512.4388619096 1011158.47999252 992355.7178639037 1.0 0.9652949621210349 0.9473450443624976 19.998535944874426 -13.999999766763649 0.08385028350735073 1.18307436534769 0.8973615683099814 0.9998702357010751 0.00024890439460448693 12.220949734490558 0.08257232528714335 0.4081133249159143 0.045188198402180565 1.0000005370466894e-14 13.999999766763649 -0.2857127970377087 HQCSIDLK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQCSIDLKK 9 1 Q5TDH0;Q5TDH0-3;Q8WTU0 Q5TDH0 DDI2;DDI1 Protein DDI1 homolog 2;Protein DDI1 homolog 1 1 23227200.0 6910000.0 10691000.0 5626200.0 True False 9059076.916535197 9095944.473191604 5044054.794321259 1.0 1.004069681381015 0.5567956692270194 23.11093262226858 -6.904845755562473 0.9301122898446486 1.0162053907314774 0.5049369515252181 0.9888270575407687 0.02218627959485034 0.10792617594846884 0.1579816612734299 0.01771346601976777 0.04731604895520079 1.2449566932542817e-07 6.904845755562473 -0.5112684392062593 HQCSIDLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQCSIDLKK 9 1 Q5TDH0;Q5TDH0-3;Q8WTU0 Q5TDH0 DDI2;DDI1 Protein DDI1 homolog 2;Protein DDI1 homolog 1 1 16150100.0 9106800.0 5428000.0 1615300.0 True False 8817709.618810292 7595428.70664605 1192204.4720387193 1.0 0.8613834016991415 0.1352056853284736 23.07197253681987 -7.011616363902392 0.7190870866344257 1.0045116227606652 4.749469709410547e-12 0.9977441500558283 0.0180123788338006 0.0779065237733772 0.06299008791807612 0.017291413687217518 0.054184032343104156 9.736068843035746e-08 7.011616363902392 -1.0045116227559157 down HQCSIDLK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQCSIDLKK 9 1 Q5TDH0;Q5TDH0-3;Q8WTU0 Q5TDH0 DDI2;DDI1 Protein DDI1 homolog 2;Protein DDI1 homolog 1 1 14174000.0 3897500.0 2740900.0 7535600.0 True False 5912792.445416919 2251764.980250554 6046185.357029191 1.0 0.38082936295115954 1.022560053112581 22.49540820492103 -10.952696684091157 12.698511445012196 1.0748133770838892 0.70169470803188 0.22366746689552852 0.2619854571965952 0.1202387535277952 0.00044790165336570177 0.0549662475049386 0.08455544272257907 1.1150730406331644e-11 10.952696684091157 -0.3731186690520092 HQCSIDLK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQCSIDLKK 9 1 Q5TDH0;Q5TDH0-3;Q8WTU0 Q5TDH0 DDI2;DDI1 Protein DDI1 homolog 2;Protein DDI1 homolog 1 1 17861400.0 6910000.0 6451200.0 4500200.0 True False 9464813.735728595 6166164.652734428 3437345.4445282766 1.0 0.6514829372138469 0.3631709551295963 23.174142683791473 -7.542549064565339 0.22121769688686127 1.1714807381223358 1.023799553180643e-14 0.9999120362104931 0.002441990398067349 0.129834643435022 0.022545263733724445 0.03257713306137403 0.06898358066693885 2.8671534396579338e-08 7.542549064565339 -1.1714807381223256 down HQDVPSQDDSK(ub)PTQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQDVPSQDDSKPTQR 15 1 Q9NRN7 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 30348900.0 10230000.0 11219000.0 8899900.0 True False 13411629.06746092 9545168.931319477 7979023.721869069 1.0 0.7117083900327823 0.5949332241247 23.67698115162565 -13.999999999999995 0.12443472578976918 2.3707866491045686 0.4192217409906041 0.9996714880149692 0.0030855341278786656 11.94890554325454 0.1091092006678275 4.028631410850138 0.15601609759177426 1.0000000000000123e-14 13.999999999999995 -1.9515649081139645 HQDVPSQDDSK(ub)PTQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQDVPSQDDSKPTQR 15 1 Q9NRN7 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 37608800.0 15675000.0 7822800.0 14111000.0 True False 15177405.705061212 10946484.835363064 10414905.779074067 1.0 0.7212355687186208 0.6862111998232351 23.855421874180756 -13.999999999959302 0.29250548973081686 3.4363476754548987 0.6769056003541112 0.9996330697796092 0.002689341525175667 16.11629766975409 0.17156525433652517 23.661844808337655 0.013079825957150137 1.0000000000937108e-14 13.999999999959302 -2.7594420751007878 HQDVPSQDDSK(ub)PTQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQDVPSQDDSKPTQR 15 1 Q9NRN7 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 190602000.0 19403000.0 25909000.0 145290000.0 True False 29435769.54930714 21285336.522059068 116573367.81713091 1.0 0.7231112638792921 3.9602622796003923 24.811067009221006 -6.886094184648448 1.0451703277975006 0.8094329039884708 4.21832071203385 0.9782798944877668 0.21592436889535027 0.1223711338774007 0.24079680878400092 0.15815903688228156 0.38915181060338827 1.2998876432119064e-07 6.886094184648448 3.408887808045379 up HQDVPSQDDSK(ub)PTQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQDVPSQDDSKPTQR 15 1 Q9NRN7 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 33115000.0 10230000.0 10900000.0 11985000.0 True False 14012307.455355056 10418401.958520155 9154389.838823035 1.0 0.7435179389058135 0.6533106605025656 23.74019121314854 -13.999999999999998 0.14563986523427527 2.2326319855312335 0.5489115057234099 0.9995814364056036 0.003004602235741807 11.943993703375218 0.1199471552184701 4.17270522231094 0.09372982613301027 1.0000000000000041e-14 13.999999999999998 -1.6837204798078238 HQDVPSQDDSK(ub)PTQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HQDVPSQDDSKPTQR 15 1 Q9NRN7 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 244187000.0 19403000.0 19564000.0 205220000.0 True False 25117565.990309946 18475246.201861866 167872065.73501912 1.0 0.7355508176624038 6.683452759705385 24.582193331313455 -6.896495772026754 0.983162826256999 0.7283747284238616 7.265181134901328 0.98474057144317 0.33892192559654755 0.1140306016823156 0.19232667345276658 0.2601567440660051 0.6657285349064984 1.269124499652394e-07 6.896495772026754 6.536806406477467 up HQDVPSQDDSKPTQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQDVPSQDDSKPTQR 15 1 Q9NRN7 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 18107800.0 1376300.0 9385000.0 7346500.0 False True 1804342.628108159 7984794.58244347 6586354.652604081 1.0 4.425320589369145 3.650279359364152 20.783041888481367 -10.413283665079712 6.880305569492274 0.9997208947848538 4.037799974366642 0.9534529875216619 0.31640925718854795 0.001354757451747391 0.00011552535685395372 0.3063840633813559 0.10212064863975875 3.861146988448005e-11 10.413283665079712 3.0380790795817885 HQDVPSQDDSKPTQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQDVPSQDDSKPTQR 15 1 Q9NRN7 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 10386600.0 2376200.0 1937400.0 6073000.0 False True 2300768.8316661194 2711013.9234075327 4482299.113905238 1.0 1.178307827407559 1.948174476381161 21.13368460627048 -6.943123899015703 0.6298397056258178 0.991602101810679 2.176359785027606 0.9985450189480469 0.015693937449381246 0.08637011893816791 0.048335302839727735 0.01566607737005775 0.0654039438968625 1.1399245343470813e-07 6.943123899015703 1.1847576832169273 HQDVPSQDDSKPTQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQDVPSQDDSKPTQR 15 1 Q9NRN7 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 29499600.0 3686900.0 23378000.0 2434700.0 False True 5593296.8484945875 19206013.246852327 1953480.4778330808 1.0 3.433755398128305 0.34925385345118093 22.415267468660083 -6.696341426223227 1.84367479359349 2.516639084461154 0.35896437158346234 0.4003162470223698 1.0280215881980166 0.4031977958719305 2.6617987390656737 0.4452512022555789 1.1503713693467812 2.012141756632223e-07 6.696341426223227 -2.1576747128776916 HQDVPSQDDSKPTQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQDVPSQDDSKPTQR 15 1 Q9NRN7 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 18903900.0 1376300.0 9776800.0 7750800.0 False True 1885155.3031090093 9344828.648445873 5920220.672736708 1.0 4.95706037217959 3.140441884534948 20.84625195000426 -9.55989692036116 7.991135394350741 1.0000134499255853 4.048751128357386 0.7897123741616627 0.7416313920470534 0.0 0.0 0.7180815182872594 0.23936050252905164 2.754882496114458e-10 9.55989692036116 3.048737678431801 HQDVPSQDDSKPTQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HQDVPSQDDSKPTQR 15 1 Q9NRN7 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 4424790.0 2376200.0 1477900.0 570690.0 False True 1975915.5835086075 1469938.2593598196 690018.6404275744 1.0 0.7439276614994197 0.34921463557786075 20.914089881704758 -6.964800888218151 0.361457207531936 1.033451218377332 0.04613412755654146 0.9999089767453176 0.0025538633120193543 0.07802863276344771 0.015098856614856786 0.0052803263290010635 0.03368429570047064 1.0844239779031926e-07 6.964800888218151 -0.9873170908207904 down HQDVPSQDDSKPTQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HQDVPSQDDSKPTQR 15 1 Q9NRN7 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 9569000.0 3686900.0 2581900.0 3300200.0 False True 4772764.729664161 2438214.9953274922 2699597.4629115597 1.0 0.5108600849677875 0.5656255055131366 22.186393790752533 -10.464814405603102 8.076379295592808 1.0000219811247484 0.5382427952424033 0.9895602754923033 0.022357889314173318 8.849566454897548e-06 5.864307725889556e-07 0.021648959956702685 0.007215977747511837 3.4291429859809084e-11 10.464814405603102 -0.4617791858823451 HQEGEIFDTEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQEGEIFDTEK 11 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 33677600.0 2515600.0 18876000.0 12286000.0 False True 3297975.9611050575 16059774.378071718 11014762.575633796 1.0 4.8695850325999785 3.3398553250652148 21.653149452356402 -9.786672931531546 9.977912606095387 1.0000000002707248 4.104720180186512 0.8459713851967908 0.6245095379728525 0.0 0.0 0.6046787600291366 0.20155958667637883 1.6342822674030377e-10 9.786672931531546 3.1047201799157875 HQEGEIFDTEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQEGEIFDTEK 11 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 31972700.0 8219700.0 2610000.0 21143000.0 False True 7958770.12273631 3652186.6109701972 15605014.023596002 1.0 0.4588883149843429 1.9607318446120456 22.92411407610851 -6.809281815829272 1.4178618042017024 0.7048529141746587 1.9864974066771992 0.85786256642087 0.23414325494555907 0.20778656653038893 0.8234745190993433 0.1298631145297285 0.30045552944932924 1.5513799851450265e-07 6.809281815829272 1.2816444925025405 HQEGEIFDTEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQEGEIFDTEK 11 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 31438600.0 2515600.0 12902000.0 16021000.0 False True 3445685.3015338443 12331946.97879148 12237169.762852203 1.0 3.5789533574937686 3.5514473006007936 21.716359513879294 -10.079848779738956 4.647615218974872 0.9998646690150989 3.5652003291138326 0.9999137740383264 0.011229300931896917 1950242.104082152 0.8143794687273458 2832.3528072202266 0.00384408835670082 8.320534396120298e-11 10.079848779738956 2.5653356600987336 HQEGEIFDTEK(ub)EK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQEGEIFDTEKEK 13 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 62931000.0 22007000.0 25410000.0 15514000.0 True False 28851390.11609113 21618927.047404215 13908760.100796273 1.0 0.7493201180398863 0.48208284054358325 24.782137496610037 -6.970312967258655 0.25059796296395936 1.0841871785920212 0.1393827955979663 0.9999847212491444 0.0008265934709124343 0.07620126763364576 0.008666012340648926 0.005936312780628398 0.025587199967226963 1.0707474104286311e-07 6.970312967258655 -0.9448043829940549 down HQEGEIFDTEK(ub)EK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQEGEIFDTEKEK 13 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 74635000.0 21346000.0 28362000.0 24927000.0 True False 20668382.91420967 39687094.50587606 18397870.90602931 1.0 1.9201838223439762 0.8901456385047247 24.30092218152289 -6.671154065218039 1.933480159869162 1.5867664074904901 0.8943033771559812 0.28413236739572034 0.3907701621979782 0.4584425492105804 3.3052342505048444 0.1626517171934048 0.4338803433023046 2.132288353346482e-07 6.671154065218039 -0.692463030334509 HQEGEIFDTEK(ub)EK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQEGEIFDTEKEK 13 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 53323000.0 22007000.0 21012000.0 10304000.0 True False 30143582.616813146 20083620.362607874 7870407.417541295 1.0 0.6662652086817928 0.2610972795632935 24.84534755813293 -7.303587094030672 0.353379342525396 1.048531478632081 1.0677114975860677e-11 0.999703631659155 0.005201189898635022 0.10349953936343521 0.02679928479728883 0.012189035933873231 0.05079779611373119 4.970646816739225e-08 7.303587094030672 -1.048531478621404 down HQEGEIFDTEK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HQEGEIFDTEKEK 13 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 65002000.0 31536000.0 22419000.0 11047000.0 True False 40823973.667495474 21171362.94211516 9036559.351792008 1.0 0.5186012296243481 0.22135423232910376 25.28291328047182 -8.49137204940182 0.2536287761353547 1.2302127434348469 3.8295567229061246e-20 0.9993203032448624 0.008364367752441692 0.1601646299624687 0.06660463407887594 0.1318959033983931 0.10894272075373997 3.225729534544569e-09 8.49137204940182 -1.2302127434348469 down HQEGEIFDTEK(ub)EKYEITEQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQEGEIFDTEKEKYEITEQR 20 2 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 88932000.0 27496000.0 45418000.0 16018000.0 True False 36047522.27164279 38641811.437977426 14360611.015505651 1.0 1.0719685848803946 0.39837997483678916 25.103396763365257 -6.880471142934018 1.0772156553449017 1.044883370414802 0.35021886404334973 0.974061445160661 0.04863880940179405 0.12721137311418165 0.2697971087283618 0.0347681734130195 0.08417650697799506 1.3168274075310934e-07 6.880471142934018 -0.6946645063714523 down HQEGEIFDTEK(ub)EKYEITEQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQEGEIFDTEKEKYEITEQR 20 2 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 107932000.0 36678000.0 41190000.0 30064000.0 True False 35513676.96652219 57637381.80301231 22189336.499332666 1.0 1.62296294628533 0.6248110135216348 25.081871404089995 -6.738020402893389 1.6947534208373853 1.371525527959204 0.6245662481908488 0.5956863479387942 0.2617551339915441 0.32140299418712887 1.811942367014838 0.12224526463238926 0.3005394631356496 1.8280143351121247e-07 6.738020402893389 -0.7469592797683552 HQEGEIFDTEK(ub)EKYEITEQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQEGEIFDTEKEKYEITEQR 20 2 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 258924000.0 80323000.0 82405000.0 96196000.0 True False 121855863.39787647 67699183.91679637 77182818.4357953 1.0 0.5555677177038995 0.6333943749902505 26.86060043068966 -10.773214377686136 7.064197561994554 1.0101380100491655 0.594481046347075 0.9731180212770224 0.03177259978966977 0.0050622589234785445 0.00016251614885425734 0.030698176168583845 0.010254562487592033 1.68572070969537e-11 10.773214377686136 -0.4156569637020905 HQEGEIFDTEK(ub)EKYEITEQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQEGEIFDTEKEKYEITEQR 20 2 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 71818000.0 27496000.0 28373000.0 15949000.0 True False 37662014.25146069 27119387.043036003 12182174.679965671 1.0 0.7200726669042722 0.3234605190956614 25.16660682488815 -6.99774943943557 0.3425702919189483 1.0426572066517903 2.862429579875378e-13 0.9999353631532328 0.0022315092885607265 0.07413782879202938 0.013554193281525727 0.005539766526941651 0.03287777440714599 1.0051955575477526e-07 6.99774943943557 -1.042657206651504 down HQEGEIFDTEK(ub)EKYEITEQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HQEGEIFDTEKEKYEITEQR 20 2 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 77257200.0 36678000.0 33023000.0 7556200.0 True False 30499382.110903453 32845098.544447728 9136166.484078623 1.0 1.0769102936254464 0.299552510633075 24.86227667952427 -6.882568657763698 1.0653202934965211 1.0495071462141345 0.2416631403649815 0.9757010370156004 0.054517025135530355 0.12538129146529703 0.25871665205759564 0.03932375679864663 0.09575102720088516 1.3104828513053233e-07 6.882568657763698 -0.8078440058491531 down HQEGEIFDTEK(ub)EKYEITEQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HQEGEIFDTEKEKYEITEQR 20 2 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 278844000.0 80323000.0 119550000.0 78971000.0 True False 103979706.90303898 112896937.40710409 64599088.310886815 1.0 1.0857593348707977 0.6212663050793693 26.63172675278211 -6.8590344636103495 1.1905841805452484 1.0464173097769431 0.5991830668216759 0.9524527458286541 0.044005471869946584 0.14780664310321803 0.3986644824968376 0.0288384649645718 0.06724702765581747 1.3834565898708944e-07 6.8590344636103495 -0.44723424295526726 HQEIETK(ub)EIYAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQEIETKEIYAQR 13 1 O75665;O75665-3;A6NF31;O75665-2;A0A0A0MS89 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 2589920.0 310660.0 899960.0 1379300.0 True False 407278.2684357192 765689.4760166048 1236583.2671798572 1.0 1.8800155455322403 3.0362122485183063 18.63565531147285 -6.967365776593207 0.31481799680858885 0.8317151105166559 4.121522936307589 0.9999539351910787 0.005659256378759749 0.07716708781710462 0.012075472975454426 0.017908926811912678 0.10218030082252705 1.0780383816347642e-07 6.967365776593207 3.2898078257909336 HQEIETK(ub)EIYAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQEIETKEIYAQR 13 1 O75665;O75665-3;A6NF31;O75665-2;A0A0A0MS89 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 33116200.0 1861200.0 0.0 31255000.0 True False 2823576.471946111 0.0 25077435.550446864 1.0 0.0 8.881443729116565 21.429092274205768 -6.878929878079964 1.085808653377947 0.38864707312394153 9.497946120376367 0.9728093702827881 0.6549803415673012 0.12857949847169492 0.2780824871773483 0.46513024720542706 1.1217553814859378 1.321508990033645e-07 6.878929878079964 9.109299047252426 up HQEIETK(ub)EIYAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HQEIETKEIYAQR 13 1 O75665;O75665-3;A6NF31;O75665-2;A0A0A0MS89 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 26093900.0 1861200.0 4349700.0 19883000.0 True False 2409360.0897368873 4107635.3713064077 16264498.01680826 1.0 1.7048656980762804 6.750546788788394 21.200218596298217 -6.932224894786613 0.7282968381460575 0.9292482215655968 7.847642775603361 0.9969577338368111 0.1412516685610355 0.0914990123783848 0.07214036932653273 0.13043388727547423 0.45109190591480336 1.1688939349546606e-07 6.932224894786613 6.918394554037764 HQEPVYSVAFSPDGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQEPVYSVAFSPDGR 15 0 Q9BZK7;A0A0D9SF63 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 26529900.0 2513200.0 12767900.0 11248800.0 False True 3294829.537863419 10862979.088884383 10084882.082108874 1.0 3.2969775716921137 3.060820587595122 21.6517723968517 -9.670508648850081 6.636181394167941 0.9999999970996657 3.178899079645648 0.9912666848508939 0.09641068504599927 4.602900510629098e-09 8.384412930680427e-10 0.09334924508717087 0.03111641479722167 2.1354595585591738e-10 9.670508648850081 2.1788990825459824 HQEPVYSVAFSPDGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQEPVYSVAFSPDGR 15 0 Q9BZK7;A0A0D9SF63 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 17906700.0 3802200.0 3177800.0 10926700.0 False True 3681501.242219052 4446712.112008072 8064669.476026414 1.0 1.2078529435257732 2.1905926266007114 21.811862757631634 -6.94106113953503 0.649626576045367 0.989139258734719 2.4640800453258147 0.9982994950155248 0.021411989443705485 0.08728604431314259 0.05243204950619867 0.02101439138559044 0.0841949316449642 1.1453516886505934e-07 6.94106113953503 1.4749407865910957 up HQEPVYSVAFSPDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQEPVYSVAFSPDGR 15 0 Q9BZK7;A0A0D9SF63 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 23018200.0 2513200.0 9813400.0 10691600.0 False True 3442397.956676277 9379811.53942585 8166464.280413874 1.0 2.724790003211104 2.3723184777563615 21.714982458374593 -9.999478729059184 5.7267658076634085 0.9999971148033662 2.548554240484366 0.962597450711958 0.14389589770632885 5.300651311722157e-06 9.262692825424719e-07 0.13932686315877846 0.04644220128335503 1.0012009913108883e-10 9.999478729059184 1.5485571256809998 HQEPVYSVAFSPDGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HQEPVYSVAFSPDGR 15 0 Q9BZK7;A0A0D9SF63 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 7647340.0 3802200.0 869740.0 2975400.0 False True 3161697.7660198724 865054.5379901258 3597542.383304777 1.0 0.2736044372385114 1.1378514486644216 21.59226803306591 -6.683797501764787 1.8882521770701908 0.5419825041208313 1.1346780657185083 0.34165643018213143 0.3076104546232837 0.43013883537108266 2.9683087490187847 0.13055949980359793 0.3426937208437697 2.071106817459186e-07 6.683797501764787 0.592695561597677 HQEQFIQMLNEPPGELADISDVEGEVGAIGEEAPQMNYIQVTPQEK(ub)EAIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQEQFIQMLNEPPGELADISDVEGEVGAIGEEAPQMNYIQVTPQEKEAIER 51 1 P54725-3;P54725 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 92472000.0 14351000.0 54945000.0 23176000.0 True False 21771516.198634557 45139635.46275561 18595253.441598322 1.0 2.0733344913105607 0.8541092532069291 24.375938546523237 -6.674260520102206 1.9225151113656038 1.6825815585469335 0.8589586117333803 0.2979992511432926 0.4554863736490172 0.4513769898547106 3.220359818130399 0.19047428261883936 0.5060438345709167 2.1170907756450468e-07 6.674260520102206 -0.8236229468135532 HQGGWTDGGSGGGGGYQDGGYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQGGWTDGGSGGGGGYQDGGYR 22 0 Q8NCA5 Q8NCA5 FAM98A Protein FAM98A 0 5020800.0 1079000.0 1425200.0 2516600.0 False True 1414579.449050863 1212565.7153860887 2256206.3729317966 1.0 0.8571916665406676 1.5949661748908044 20.431941776480976 -6.856509161150551 1.2031138205272247 0.9231181188714348 1.6284043601794327 0.9492621451872324 0.07196632655759638 0.15045027073121262 0.4157947836545705 0.04671261935914199 0.10865717415479256 1.3915244412611283e-07 6.856509161150551 0.7052862413079979 HQGGWTDGGSGGGGGYQDGGYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQGGWTDGGSGGGGGYQDGGYR 22 0 Q8NCA5 Q8NCA5 FAM98A Protein FAM98A 0 13040200.0 3827300.0 7239200.0 1973700.0 False True 5806293.913109471 5947308.199872234 1583597.3298965609 1.0 1.024286453437085 0.2727380586644278 22.469186171990305 -6.899430144475709 0.9648418496803907 1.0317370784870639 0.19475109300048843 0.9862812900163243 0.040842140024497445 0.1118266991739876 0.17978560179672695 0.03178114431296655 0.08245716794133738 1.260578383464347e-07 6.899430144475709 -0.8369859854865754 down HQGGWTDGGSGGGGGYQDGGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQGGWTDGGSGGGGGYQDGGYR 22 0 Q8NCA5 Q8NCA5 FAM98A Protein FAM98A 0 5481400.0 1079000.0 1853300.0 2549100.0 False True 1477935.4588786021 1771415.0779564616 1947055.0803624373 1.0 1.1985740428073497 1.317415499212519 20.495151838003867 -12.09983833575848 0.06434446625872559 1.1853648013147592e-14 1.8498723312755418 0.9999648080330148 0.0007767514912394298 6.08884457382273 0.050382964310502425 1.2479740537432131 0.40305967572980667 7.946239750128821e-13 12.09983833575848 1.84987233127553 HQGGWTDGGSGGGGGYQDGGYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HQGGWTDGGSGGGGGYQDGGYR 22 0 Q8NCA5 Q8NCA5 FAM98A Protein FAM98A 0 7950300.0 3827300.0 2248500.0 1874500.0 False True 4954515.297361909 2123368.9984096503 1533360.2339942178 1.0 0.4285724982099184 0.3094874355944917 22.240312494082755 -13.999999999999908 0.2204376593895734 4.454870071527254 0.24605509127468123 0.9994983345625201 0.006750476093867039 13.011545840369372 0.1487334879397028 19.572934299764267 0.0657148143589633 1.0000000000002127e-14 13.999999999999908 -4.208814980252573 HQGVMVGMGQK ddPTM_RPMI8226_Bortezomib_1h_R1 4 HQGVMVGMGQK 11 0 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q562R1 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q562R1 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 2817981590.0 761840710.0 991110900.0 1065029980.0 False True 998780548.48593 843241017.0400302 954830894.1585555 1.0 0.8442705640576551 0.955996685764457 29.895592483772965 -10.466986617105823 4.617941495789948 1.0003451395016065 0.9001336249110076 0.5158064996888916 0.04561199818712511 0.00016263597958946136 1.877175703021423e-05 0.04431568174025708 0.014721209113808134 3.412034257296936e-11 10.466986617105823 -0.10021151459059896 HQGVMVGMGQK ddPTM_RPMI8226_Bortezomib_2h_R1 4 HQGVMVGMGQK 11 0 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q562R1 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q562R1 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 1812347350.0 392934430.0 354668820.0 1064744100.0 False True 380460941.6010823 496289929.3994633 785855678.571684 1.0 1.3044438341316755 2.065535755824478 28.503173112300104 -6.955462351893854 0.4952639773864664 0.9841116427833864 2.418431137414008 0.9995631318924058 0.009366354020081158 0.0813637235444141 0.02743795341291854 0.011084681436908463 0.06277548818988724 1.1079946110126012e-07 6.955462351893854 1.4343194946306217 up HQGVMVGMGQK ddPTM_RPMI8226_Bortezomib_8h_R1 4 HQGVMVGMGQK 11 0 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q562R1 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q562R1 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 3727268800.0 982697300.0 2034129100.0 710442400.0 False True 1490823648.895857 1671122869.381802 570023148.2420343 1.0 1.1209393348565937 0.38235451165817524 30.47346246378021 -6.864889576956133 1.1608563520447088 1.0666767771766181 0.3431129197733857 0.9593073852015295 0.06524907155661216 0.14184519818191632 0.36049591086599575 0.04374546931127317 0.1027399725144873 1.364930137500673e-07 6.864889576956133 -0.7235638574032324 down HQGVMVGMGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 4 HQGVMVGMGQK 11 0 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q562R1 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q562R1 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 2489204540.0 761840710.0 797682950.0 929680880.0 False True 1043513808.4580632 762438679.6842334 710109403.5227413 1.0 0.7306455108733468 0.6804983295544759 29.958802545295857 -13.999999999999998 0.23640348616917095 2.752305181799743 0.6575558383270048 0.9995191747531127 0.003076377414127673 13.499167431068809 0.1539070317804876 11.143694791717676 0.025032512947739536 1.0000000000000041e-14 13.999999999999998 -2.0947493434727384 HQGVMVGMGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 4 HQGVMVGMGQK 11 0 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q562R1 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q562R1 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 1270529310.0 392934430.0 561015580.0 316579300.0 False True 326742388.4917395 557993277.7176657 382774567.93270046 1.0 1.7077468286052286 1.1714873289003258 28.28357838773438 -10.230654370788823 3.6539599849354634 0.9993642274318613 1.4396170773457064 0.4725909531181759 0.21892702669278458 62721472.24786025 99594480.28439349 477252.9856140917 0.08011908704569282 5.879570865455244e-11 10.230654370788823 0.44025284991384517 HQGVMVGMGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 4 HQGVMVGMGQK 11 0 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q562R1 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q562R1 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 2828467100.0 982697300.0 1091061400.0 754708400.0 False True 1272121026.7097554 1030342873.969949 617359215.162124 1.0 0.8099409194067428 0.48529912028800976 30.244588785872658 -6.963008654449318 0.39072616949395755 1.0197777083363337 0.2637840675936372 0.9998660267058913 0.0024596905874379876 0.07864338056125672 0.017284374339468674 0.004189827517969501 0.02729989864928753 1.0889083937797958e-07 6.963008654449318 -0.7559936407426966 down HQGVMVGMGQK(ub)DSYVGDEAQSK ddPTM_RPMI8226_Bortezomib_1h_R1 3 HQGVMVGMGQKDSYVGDEAQSK 22 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 164650560.0 45640860.0 53125700.0 65884000.0 True False 59835609.44671703 45199552.642356634 59066955.68395392 1.0 0.7553955422248411 0.9871539076835577 25.834500982788764 -10.574196275913959 8.318110073113315 1.0000369642230038 0.8712747249915621 0.2914509491780277 0.09461495649922028 6.487725753685948e-05 3.3210742107350595e-06 0.09163679873473449 0.03053684590196826 2.665653671414002e-11 10.574196275913959 -0.1287622392314417 HQGVMVGMGQK(ub)DSYVGDEAQSK ddPTM_RPMI8226_Bortezomib_2h_R1 4 HQGVMVGMGQKDSYVGDEAQSK 22 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 310023110.0 62648510.0 67425400.0 179949200.0 True False 60659767.342110544 94348713.83881605 132815106.15971619 1.0 1.5553754650377358 2.1895089938387344 25.854236628790385 -6.96939489283986 0.2722487698930757 0.8465948896779024 2.9174111196817427 0.9999772715628543 0.00231682176553242 0.07649952913523127 0.009730565466445941 0.012261595428127218 0.058797466069212996 1.0730133051407067e-07 6.96939489283986 2.07081623000384 HQGVMVGMGQK(ub)DSYVGDEAQSK ddPTM_RPMI8226_Bortezomib_8h_R1 2 HQGVMVGMGQKDSYVGDEAQSK 22 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 359750700.0 66071500.0 96631000.0 197048200.0 True False 100235295.97366618 79386443.06855102 158101536.90070572 1.0 0.7920008844928978 1.5773040361175985 26.578815375013512 -6.836292122434877 1.299682488160087 0.8892472760707609 1.6012655786999734 0.917855498383666 0.09521296841635517 0.1731782412464769 0.569862147043661 0.05747980314676048 0.1323068832112537 1.4578333381113592e-07 6.836292122434877 0.7120183026292125 HQGVMVGMGQK(ub)DSYVGDEAQSK ddPTM_RPMI8226_Carfilzomib_1h_R1 3 HQGVMVGMGQKDSYVGDEAQSK 22 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 161668060.0 45640860.0 40237700.0 75789500.0 True False 62515519.33986483 38459865.365719885 57889581.03374866 1.0 0.6152050846228009 0.926003361165932 25.897711044311656 -9.9220571385509 6.49981470199237 1.0000000226025034 0.770604222894358 0.4207467941930816 0.1268828650778783 4.15135237863409e-08 7.041218777881664e-09 0.12285381682538553 0.04095126861380433 1.1965830908502445e-10 9.9220571385509 -0.2293957997081454 HQGVMVGMGQK(ub)DSYVGDEAQSK ddPTM_RPMI8226_Carfilzomib_2h_R1 4 HQGVMVGMGQKDSYVGDEAQSK 22 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 263122310.0 62648510.0 92934500.0 107539300.0 True False 52095011.864571474 92433843.40244602 130025270.42445639 1.0 1.7743319387802652 2.495925536258172 25.63464190422466 -6.971974235865867 0.2056338591104331 0.6005096755626356 3.689794189641201 0.9999939621329111 0.0015009383591656127 0.07566713486106097 0.0066863594842263025 0.02237673867955044 0.07554870648252764 1.0666593979740473e-07 6.971974235865867 3.0892845140785656 HQGVMVGMGQK(ub)DSYVGDEAQSK ddPTM_RPMI8226_Carfilzomib_8h_R1 4 HQGVMVGMGQKDSYVGDEAQSK 22 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 455351600.0 100189900.0 109231600.0 245930100.0 True False 129697800.58818503 103152765.43770657 201173345.25591967 1.0 0.7953316476447897 1.5510929587363087 26.950578773712238 -6.83456934090559 1.3072334573954145 0.8909313455099522 1.5734150874900543 0.9147283559535593 0.09319888672269558 0.1752412836976466 0.5840131291304997 0.055947001542543805 0.1287731781580329 1.4636278311924192e-07 6.83456934090559 0.6824837419801021 HQGVMVGMGQK(ub)DSYVGDEAQSK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 3 HQGVMVGMGQKDSYVGDEAQSKR 23 2 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 2 36942400.0 11119500.0 10459800.0 15363100.0 True False 14577772.181391174 8899238.611981058 13773473.78526125 1.0 0.6104662976789499 0.9448270705480891 23.797266923764056 -10.124454968712174 7.356166163324506 1.0000000806099918 0.7776466841135196 0.3709312521681677 0.1365022139220021 1.8042138890005925e-07 2.1418261262801826e-08 0.13216774757670663 0.044055900103363035 7.508359030363292e-11 10.124454968712174 -0.22235339649647223 HQGVMVGMGQK(ub)DSYVGDEAQSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 2 HQGVMVGMGQKDSYVGDEAQSKR 23 2 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 2 68596600.0 8734500.0 11388400.0 48473700.0 True False 8457228.078523586 15935847.509721428 35776983.79017097 1.0 1.884287305694068 4.230343968258771 23.01175345575997 -6.954176073027725 0.5109447878703869 0.957156046799535 5.260566276631283 0.9994895667139675 0.030795002145142247 0.08185091974903579 0.02934834562660791 0.03541224377911889 0.193638132024591 1.1112810968803664e-07 6.954176073027725 4.303410229831748 HQGVMVGMGQK(ub)DSYVGDEAQSK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 3 HQGVMVGMGQKDSYVGDEAQSKR 23 2 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 2 42615900.0 11119500.0 11848600.0 19647800.0 True False 15230679.643188713 11325089.673919454 15007394.29914285 1.0 0.7435708674355926 0.9853397649168126 23.860476985286947 -10.548922953336234 8.313163875099642 1.0000241104368508 0.8644553162319306 0.29532092899757134 0.09870173908404102 4.411389924968256e-05 2.393606926089642e-06 0.09558452653542615 0.03185584930951672 2.8253811714398758e-11 10.548922953336234 -0.13556879420492018 HQGVMVGMGQK(ub)DSYVGDEAQSK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 2 HQGVMVGMGQKDSYVGDEAQSKR 23 2 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 2 42685200.0 8734500.0 14298100.0 19652600.0 True False 7263123.753958401 14221073.297349354 23761867.79664431 1.0 1.9579830633615283 3.2715768864180648 22.792158731194245 -6.966706123830432 0.3274516404518092 0.8351317993828122 4.437267332337964 0.9999441176755711 0.006960742794712284 0.07738667553449588 0.012843658267326672 0.01934533162144832 0.11481299090689198 1.0796770654560157e-07 6.966706123830432 3.6021355329551517 HQGVMVGMGQK(ub)DSYVGDEAQSK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 2 HQGVMVGMGQKDSYVGDEAQSKR 23 2 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 2 32121300.0 5965800.0 10615000.0 15540500.0 True False 7722845.703498994 10024265.91866507 12712288.458995547 1.0 1.2980015791489101 1.6460627270121406 22.88070111705609 -6.969081540301758 0.279259197134775 0.9226333371983767 2.032026315288227 0.9999743028445092 0.0013383560924302529 0.0766019157385099 0.010092736232456925 0.006456665709220282 0.03197760762730182 1.0737877860166582e-07 6.969081540301758 1.1093929780898506 HQGVMVGMGQK(ub)DSYVGDEAQSKR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 HQGVMVGMGQKDSYVGDEAQSKR 23 2 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 1 62052900.0 9344900.0 14441800.0 38266200.0 True False 12097157.265518079 13638101.134637514 31302144.24436893 1.0 1.1273806593811726 2.58756198314401 23.528164729829072 -6.924064445109759 0.7939965156088931 0.9722527615356781 2.846549043668544 0.9952375939859296 0.04970388378847264 0.09583880044917915 0.09365034918855424 0.04377428510687418 0.13668540473918908 1.1910652523247475e-07 6.924064445109759 1.8742962821328657 up HQITYLIHQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQITYLIHQAK 11 0 Q92733;H0YE12;H0Y679 Q92733 PRCC Proline-rich protein PRCC 0 14836600.0 3913700.0 4176000.0 6746900.0 False True 5130898.600324711 3552957.077920503 6048795.508834754 1.0 0.6924629299233575 1.178895936172263 22.290780083792463 -6.735858930691447 1.702019535297879 0.8161432864634776 1.178922595184064 0.5861520912746072 0.12923256751124476 0.32535512139121664 1.8489783964900923 0.06011024670099578 0.14817175150556772 1.8371349921365822e-07 6.735858930691447 0.3627793087205865 HQITYLIHQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQITYLIHQAK 11 0 Q92733;H0YE12;H0Y679 Q92733 PRCC Proline-rich protein PRCC 0 10599800.0 2572300.0 1365800.0 6661700.0 False True 2490643.744505831 1911171.0625529094 4916800.923283804 1.0 0.767340197396278 1.9741084746182145 21.248087246145264 -6.856749982581625 1.202151781706272 0.8747083313674181 2.028988189404565 0.9495462590078977 0.11741723672674426 0.15019689618641432 0.4143359020450137 0.07627552003719042 0.17743632820607835 1.3907530383823858e-07 6.856749982581625 1.154279858037147 HQITYLIHQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQITYLIHQAK 11 0 Q92733;H0YE12;H0Y679 Q92733 PRCC Proline-rich protein PRCC 0 11919400.0 3913700.0 3193100.0 4812600.0 False True 5360700.653765695 3052018.283830343 3675962.9986082376 1.0 0.5693319737386217 0.68572435508519 22.353990145315354 -10.235379613747037 8.070656423256592 1.0000002512493853 0.6275281644119106 0.9317616773127678 0.04751699070775456 2.1480790964024466e-07 2.0302256191233726e-08 0.04600815926811285 0.015336042806085505 5.8159462775897646e-11 10.235379613747037 -0.3724720868374747 HQIVEVAGDDK(ub)YGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQIVEVAGDDKYGR 14 1 Q07960;H0YE29;E9PNR6 Q07960 ARHGAP1 Rho GTPase-activating protein 1 1 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 HQIVEVAGDDK(ub)YGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQIVEVAGDDKYGR 14 1 Q07960;H0YE29;E9PNR6 Q07960 ARHGAP1 Rho GTPase-activating protein 1 1 5466300.0 2414700.0 3051600.0 0.0 True False 3663276.43821635 2507018.1377403773 0.0 1.0 0.6843649885622732 0.0 21.804703143151354 -7.460485083460746 0.7323316571750847 0.9919213234618978 2.147374510203605e-17 0.9871840313752144 0.04725250575021859 0.11711304986885698 0.14090047036235787 0.04138495451213766 0.0746628521606829 3.4634978034167514e-08 7.460485083460746 -0.9919213234618978 down HQIVEVAGDDK(ub)YGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HQIVEVAGDDKYGR 14 1 Q07960;H0YE29;E9PNR6 Q07960 ARHGAP1 Rho GTPase-activating protein 1 1 13009700.0 2414700.0 4685600.0 5909400.0 True False 3125876.750853029 4424842.241026575 4833949.835564381 1.0 1.4155523693693512 1.5464300805350792 21.575829465243803 -11.979017424973039 0.19345887601086847 1.1024870085590336e-08 1.6474757085096143 0.9994212329550671 0.005604251392186047 5.217061896315471 0.12216120803542062 2.1833051862076616 0.08688392657065278 1.0495003192486703e-12 11.979017424973039 1.6474756974847442 HQIVEVAGDDKYGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQIVEVAGDDKYGR 14 1 Q07960;H0YE29;E9PNR6 Q07960 ARHGAP1 Rho GTPase-activating protein 1 0 4069240.0 700340.0 1927600.0 1441300.0 False True 918152.5221022086 1640009.5937259484 1292168.101925851 1.0 1.7862060542740446 1.4073566981739523 19.808374306292535 -10.111590430587286 4.589028896316348 0.9999526292024286 1.5967813760497045 0.767902718740449 0.1546646020283167 107783475.47952227 5.522513341052446 56933.21178626563 0.05294580710292622 7.734096194681616e-11 10.111590430587286 0.5968287468472759 HQIVEVAGDDKYGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQIVEVAGDDKYGR 14 1 Q07960;H0YE29;E9PNR6 Q07960 ARHGAP1 Rho GTPase-activating protein 1 0 4280730.0 987610.0 916820.0 2376300.0 False True 956258.8611403826 1282911.00715314 1753875.7425280774 1.0 1.3415938500409916 1.8341014277624577 19.86704168587619 -6.965906597255874 0.3421356870698967 0.9478849393768137 2.2442308608346373 0.9999306322978799 0.0028515280484214933 0.07765464736540506 0.01378259603054345 0.0069079825964088225 0.042562711395631204 1.0816665578944065e-07 6.965906597255874 1.2963459214578235 HQLASISSPVVTSLLINLGSPVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQLASISSPVVTSLLINLGSPVK 23 0 Q9H583;Q5T3Q7 Q9H583 HEATR1 HEAT repeat-containing protein 1;HEAT repeat-containing protein 1, N-terminally processed 0 40147500.0 8977500.0 12573000.0 18597000.0 False True 13619523.84316367 10329249.916702617 14921294.798645323 1.0 0.7584149075731008 1.09558123840982 23.699172929887904 -6.714370485237116 1.7794315940994236 0.8521450641428362 1.0949013772335405 0.4858556359096148 0.10173648521662489 0.3663907924941241 2.2640191294444056 0.045450984163104995 0.11486745295987517 1.930320908274365e-07 6.714370485237116 0.24275631309070433 HQLFLQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQLFLQLK 8 0 I3L4X7;I3L3Y9;Q13227-2;Q13227 I3L4X7 GPS2 G protein pathway suppressor 2 0 29927700.0 9193600.0 11828000.0 8906100.0 False True 12052898.63094904 10063308.505182894 7984582.205343653 1.0 0.8349284942414315 0.6624615745826571 23.52287680963812 -6.970573079622058 0.24411066050736008 1.0588553113093684 0.4335208301026219 0.9999865120666227 0.0005060888701922808 0.07611719175692262 0.008362042420568483 0.004005392209427187 0.016693273086116966 1.0701062987813959e-07 6.970573079622058 -0.6253344812067465 HQLFLQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQLFLQLK 8 0 I3L4X7;I3L3Y9;Q13227-2;Q13227 I3L4X7 GPS2 G protein pathway suppressor 2 0 22690800.0 9862800.0 3897400.0 8930600.0 False True 9549710.812623767 5453652.1446725 6591407.947742813 1.0 0.5710803449108967 0.6902206859530896 23.187025614984545 -10.331519324444221 8.482752450681858 1.000000788644735 0.6306505154319968 0.9276114227749164 0.04863884055575689 7.2543394588575e-07 5.7165245101684834e-08 0.0470944552034857 0.015698118287607032 4.661016877971702e-11 10.331519324444221 -0.3693502732127383 HQLFLQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQLFLQLK 8 0 I3L4X7;I3L3Y9;Q13227-2;Q13227 I3L4X7 GPS2 G protein pathway suppressor 2 0 34439700.0 9723700.0 10147000.0 14569000.0 False True 14751563.79769096 8336188.571127151 11689430.764180455 1.0 0.5651054142769597 0.7924197681340187 23.81436456536988 -10.006670946813744 4.961644208931379 1.0000037868732556 0.6787625912013022 0.7269842235218712 0.09280069637454195 3.88741685953183e-06 7.78281771266372e-07 0.08985494681326019 0.02995129596251559 9.847569468859078e-11 10.006670946813744 -0.3212411956719534 HQLFLQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQLFLQLK 8 0 I3L4X7;I3L3Y9;Q13227-2;Q13227 I3L4X7 GPS2 G protein pathway suppressor 2 0 23055000.0 9193600.0 6190000.0 7671400.0 False True 12592722.367698163 5916505.332407322 5859573.317442389 1.0 0.4698352873707329 0.4653142621863001 23.58608687116101 HQLFLQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HQLFLQLK 8 0 I3L4X7;I3L3Y9;Q13227-2;Q13227 I3L4X7 GPS2 G protein pathway suppressor 2 0 18599900.0 9862800.0 4432200.0 4304900.0 False True 8201355.196123512 4408322.858877176 5205034.686391319 1.0 0.5375115152872336 0.6346554394877999 22.96743089041882 -10.000457581628382 5.959254273062094 1.0000004574939283 0.5860834773874832 0.9603277780892595 0.039658840984034875 2.410562055949067e-07 4.051979707268948e-08 0.03839955000624538 0.01279983588839163 9.989469342269938e-11 10.000457581628382 -0.41391698010644506 HQLFLQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HQLFLQLK 8 0 I3L4X7;I3L3Y9;Q13227-2;Q13227 I3L4X7 GPS2 G protein pathway suppressor 2 0 42753700.0 9723700.0 20482000.0 12548000.0 False True 12587521.332782388 19342158.694874987 10264392.7533526 1.0 1.5366137767330823 0.8154419350710823 23.585490887462328 -6.7074370871931865 1.8040668468522942 1.3307493544004958 0.8172394474042931 0.45307208541282895 0.22621785205428602 0.38023710225160195 2.410685939966125 0.09984188527987072 0.2544627624070074 1.9613852852711116e-07 6.7074370871931865 -0.5135099069962027 HQNVQLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQNVQLPR 8 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;K7EK45;A0A087WUW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 30361000.0 7225600.0 13564000.0 9571400.0 False True 9472831.57280994 11540304.072057897 8581043.343351891 1.0 1.2182528511519475 0.9058583251899288 23.1753643028786 -6.7188684878642215 1.763270120082442 1.1329430782458865 0.9063727834145668 0.5071902026523233 0.0918547959390874 0.3575386161654083 2.1718515170651425 0.04137166830001231 0.1040014192820558 1.910431683861927e-07 6.7188684878642215 -0.22657029483131963 HQNVQLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQNVQLPR 8 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;K7EK45;A0A087WUW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 21015500.0 6069900.0 6592700.0 8352900.0 False True 5877214.346995275 9225199.490476318 6165024.908371334 1.0 1.5696551028792578 1.0489705742182438 22.486701084922903 -10.368639486612121 3.6808373386349427 0.9985424067014734 1.3093128386236004 0.31997204884989805 0.21256856900972101 25384213.74553475 17879372.698031697 277495.52908589446 0.07276787719469217 4.279179589108083e-11 10.368639486612121 0.31077043192212694 HQNVQLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQNVQLPR 8 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;K7EK45;A0A087WUW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 62974750.0 20555750.0 29336000.0 13083000.0 False True 31184575.576620642 24100761.596785847 10497139.315517407 1.0 0.7728423796427875 0.336613185250057 24.894329288122677 -6.960831472045449 0.4235518383975855 1.0185605489827525 0.07434307320761656 0.9997998060979411 0.003894834887518614 0.07940542068824512 0.020043606912126578 0.00565694944543086 0.03627810766662476 1.094380958367929e-07 6.960831472045449 -0.9442174757751359 down HQNVQLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQNVQLPR 8 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;K7EK45;A0A087WUW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 33138600.0 7225600.0 10683000.0 15230000.0 False True 9897099.584497904 10210989.736043205 11632987.671695856 1.0 1.0317153676049653 1.175393616319363 23.23857436440149 -6.942027558610505 0.6404211197346238 0.9984266589676615 1.2165653261420883 0.998417614080312 0.003035641361709433 0.08685364819499466 0.050487528025747914 0.0030025197560025357 0.012259876499823458 1.142805814550841e-07 6.942027558610505 0.21813866717442687 HQNVQLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HQNVQLPR 8 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;K7EK45;A0A087WUW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 19178100.0 6069900.0 8429500.0 4678700.0 False True 5047390.792163492 8384088.610375255 5656994.538135398 1.0 1.6610738014168178 1.1207760149894412 22.26710636035718 -10.392438674151325 3.729951250976555 0.9979015442196183 1.39092490794993 0.4110738662217178 0.22057564812622213 28269648.150521364 26263751.903439563 436391.6486216595 0.07550891084117159 4.0509914433179216e-11 10.392438674151325 0.39302336373031166 HQNVQLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HQNVQLPR 8 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;K7EK45;A0A087WUW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 50148650.0 20555750.0 11619000.0 17973900.0 False True 26609823.58940956 10972392.436078154 14702834.627788046 1.0 0.41234367447836273 0.5525340887129979 24.665455610215126 -10.131168055776023 7.840494668054468 1.00000007977915 0.4824388815960356 0.947843179382188 0.05723249695071062 7.979427782926973e-08 8.846763037490165e-09 0.05541513514537403 0.018471708962664087 7.39319130752988e-11 10.131168055776023 -0.5175611981831143 HQPTAIIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQPTAIIAK 9 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 80554000.0 17231000.0 40831000.0 22492000.0 False True 22590007.865241345 34739173.95799139 20164743.598498765 1.0 1.5378115034410258 0.8926399547441384 24.429181437250755 -6.685453439373983 1.88228259918809 1.3385905141634866 0.8949651989239241 0.3493862745840739 0.2276690988908141 0.4265021676510228 2.925965023548891 0.09688561642380661 0.2537792645838561 2.0632248533847121e-07 6.685453439373983 -0.4436253152395625 HQPTAIIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQPTAIIAK 9 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 44583000.0 11824000.0 13673000.0 19086000.0 False True 11448653.592130374 19132700.20375305 14086804.032273233 1.0 1.671174697512428 1.2304332486709426 23.448674605750142 -10.24215678108333 4.149009391333323 0.9996766631676499 1.4508039731168756 0.5824479021646094 0.17993194311782945 25165817.805738 31062165.992311027 60215.53094033918 0.06159548777710378 5.725892879155633e-11 10.24215678108333 0.4511273099492257 HQPTAIIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQPTAIIAK 9 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 147484000.0 36782000.0 81298000.0 29404000.0 False True 55800983.12439391 66789736.71582676 23592286.511768952 1.0 1.1969275983352525 0.42279338446736736 25.733787204477345 -6.839243177253307 1.2857607139046747 1.1047805150846404 0.3976889106130727 0.9231610705363963 0.09106066760467145 0.1696908333493357 0.545235985221215 0.05553809654704773 0.12793451151977853 1.4479608606402374e-07 6.839243177253307 -0.7070916044715676 down HQPTAIIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQPTAIIAK 9 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 71691000.0 17231000.0 27014000.0 27446000.0 False True 23601766.35026616 25820432.156648047 20963820.068113226 1.0 1.0940042272029724 0.8882309805544201 24.492391498773646 -6.782468653410824 1.5259710336909558 1.053056506810912 0.8864647039652909 0.7761204420743246 0.0397978226731087 0.24675673650839033 1.1350263628783737 0.020537001195711526 0.04836540562722537 1.6501801040332227e-07 6.782468653410824 -0.16659180284562103 HQPTAIIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HQPTAIIAK 9 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 33308900.0 11824000.0 13813000.0 7671900.0 False True 9832179.892014887 13738586.627334166 9276058.819142265 1.0 1.397308305810376 0.943438680030227 23.22907988118442 -6.675441440302254 1.9182932655469669 1.2524034388475134 0.9452297099678729 0.30334081908584665 0.16855900611540142 0.44870361949595117 3.188305372179571 0.07061476180538155 0.18732214320335705 2.1113418671811017e-07 6.675441440302254 -0.30717372887964045 HQPTAIIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HQPTAIIAK 9 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 84268000.0 36782000.0 20045000.0 27441000.0 False True 47615024.081615224 18929478.12902888 22447019.5684371 1.0 0.39755263163539584 0.4714272438455866 25.504913526569794 -10.508848025562218 6.227394215464043 1.000494132446687 0.4344899377414354 0.9873628880361845 0.030159184143491245 0.00020707543499088918 1.6331927553869182e-05 0.029225545438795086 0.009733834826912025 3.0985033814413884e-11 10.508848025562218 -0.5660041947052515 HQPTLK(ub)TDATTAIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQPTLKTDATTAIIK 15 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 9851700.0 2301200.0 2652300.0 4898200.0 True False 2228149.665613196 3711377.2215617816 3615214.477149789 1.0 1.665676807460057 1.6225186902581195 21.087414711600868 -10.203743140042429 4.823728964596655 0.9999071071258068 1.6440977488607844 0.9966439935899359 0.017619227573492234 12390481.04052406 2.176331593310825 12785.346091936544 0.006031530241456891 6.255425554721058e-11 10.203743140042429 0.6441906417349776 HQPTLK(ub)TDATTAIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQPTLKTDATTAIIK 15 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 22670600.0 3627800.0 9260500.0 9782300.0 True False 5503637.827705839 7607891.422383254 7848824.117265605 1.0 1.382338674991367 1.4261156643981685 22.391954104523286 -12.058239054207062 0.34341718913758107 4.6697654301068624e-20 1.4332747246998003 0.9996008749270597 0.003823622456474245 5.55121852184682 0.18173810713996755 3.97819017489818 0.013355577481892958 8.745022793664305e-13 12.058239054207062 1.4332747246998003 HQPTLK(ub)TDATTAIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQPTLKTDATTAIIK 15 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 12017600.0 2742000.0 4464000.0 4811600.0 True False 3755791.4997637905 4266765.719526053 3675199.178012591 1.0 1.1360496768242856 0.9785418541587657 21.840685544295077 -6.678211604618174 1.9083011756995967 1.0862178750737976 0.9791501263480954 0.3159524354700053 0.05768371605037613 0.4424959300498933 3.1139284993779395 0.024269320431415428 0.06415434211396148 2.0979174502135971e-07 6.678211604618174 -0.10706774872570224 HQPTLK(ub)TDATTAIIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HQPTLKTDATTAIIK 15 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 8687600.0 2301200.0 2940400.0 3446000.0 True False 1913549.7604452525 2924559.481576296 4166542.667496226 1.0 1.528342529695072 2.1773892446500778 20.867819987035144 -6.968363322074582 0.29467093766682656 0.8800612303972973 2.8458550347226703 0.9999666518503777 0.002780601716234725 0.07683745555239867 0.010921165262121805 0.011062948988491183 0.05854759578763877 1.0755650409547966e-07 6.968363322074582 1.965793804325373 HQQLLGEVLTQLSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQQLLGEVLTQLSSR 15 0 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 0 3950900.0 1062800.0 1136300.0 1751800.0 False True 1029061.9957473065 1590030.515726219 1292951.0271264955 1.0 1.5451260684945771 1.2564364756154 19.972898469207134 -10.130953817856339 4.636794425287859 0.9999679143834331 1.4007812719346104 0.7198685437326484 0.11785703282967702 82290106.43535025 3.7288110242529378 32892.2786610538 0.040345597141203046 7.396839276191805e-11 10.130953817856339 0.4008133575511773 HQQLSDLHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQQLSDLHK 9 0 P52756;E9PGM9;P78332-2;P78332 P52756 RBM5;RBM6 RNA-binding protein 5;RNA-binding protein 6 0 3808990.0 704490.0 1561700.0 1542800.0 False True 923593.2122908639 1328700.44745892 1383165.8555826014 1.0 1.438620844953197 1.4975920537049225 19.816898044874204 -11.900282264425348 0.3253879145680753 1.307821137420674e-12 1.5096975318901293 0.999524507805612 0.004840376804229181 4.979888503651676 0.17370990210643464 3.4091646708056014 0.019213128921936714 1.2581074543480805e-12 11.900282264425348 1.5096975318888215 HQQLSDLHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQQLSDLHK 9 0 P52756;E9PGM9;P78332-2;P78332 P52756 RBM5;RBM6 RNA-binding protein 5;RNA-binding protein 6 0 2746940.0 553290.0 1273000.0 920650.0 False True 839381.3809171853 1045823.2040056024 738683.1239647698 1.0 1.2459452017661385 0.8800327726564731 19.67896693628303 -6.725607352394507 1.738994475038572 1.1487300359610877 0.8804107088430697 0.5388236276469963 0.10343071390885081 0.3445735984938208 2.039257442440489 0.04717096395212831 0.11764941075968516 1.8810166839508815e-07 6.725607352394507 -0.268319327118018 HQQLSDLHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQQLSDLHK 9 0 P52756;E9PGM9;P78332-2;P78332 P52756 RBM5;RBM6 RNA-binding protein 5;RNA-binding protein 6 0 4254690.0 704490.0 1660000.0 1890200.0 False True 964958.9911264004 1586655.7111140795 1443773.6898909702 1.0 1.64427268485469 1.4962021217146726 19.880108106397095 -10.085035078874638 4.628895108870591 0.9999685014802961 1.5702374033008826 0.9518648200475563 0.060449554329610466 2.0695526871223496e-05 4.090644978479702e-06 0.058533425942970486 0.01951000977909293 8.221762383687439e-11 10.085035078874638 0.5702689018205864 HQTLEVSLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQTLEVSLSR 10 0 Q8NCF5;H3BSZ7;Q8NCF5-3;Q8NCF5-2 Q8NCF5 NFATC2IP NFATC2-interacting protein 0 10942900.0 2763000.0 3046700.0 5133200.0 False True 3784555.767267453 2912086.719910404 3920843.881572498 1.0 0.769465929157917 1.0360116543885542 21.851692535328343 -6.67789405361367 1.9089870403404152 0.8538691004435319 1.0349911907872897 0.3147167594907039 0.09775013315083826 0.44319693947137806 3.1206984685690666 0.041111724862323167 0.10873808011564158 2.0994519836651602e-07 6.67789405361367 0.1811220903437578 HQTLQGLAFPLQPEAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQTLQGLAFPLQPEAQR 17 0 D6RG15;Q6IBS0;H0Y858 D6RG15;H0Y858 TWF2 Twinfilin-2 0 25781000.0 6143100.0 10523000.0 9114900.0 False True 8053663.58986503 8953009.418332735 8171777.584294684 1.0 1.1116691575743824 1.014665871390294 22.941213779952786 -10.678219999194733 3.1253144202541874 0.9937660532462601 1.063167514508415 0.3611843636626534 0.03960142587804343 3089783.218163464 7052746.59966371 106050.96684537466 0.013556620296606038 2.097876899483208e-11 10.678219999194733 0.06940146126215485 HQTLQGLAFPLQPEAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQTLQGLAFPLQPEAQR 17 0 D6RG15;Q6IBS0;H0Y858 D6RG15;H0Y858 TWF2 Twinfilin-2 0 21050100.0 7483000.0 4936500.0 8630600.0 False True 7245456.260987105 6907670.193507418 6369986.947549908 1.0 0.9533796002194529 0.8791698849731343 22.788645111382085 -6.96425147605248 0.37067565272316794 1.0056632473110978 0.824300370421135 0.999896859163371 0.0005052749897592411 0.07821588130261362 0.015761281125706725 0.0009771463173974021 0.00630030243455956 1.0857967163816859e-07 6.96425147605248 -0.18136287688996278 HQTLQGLAFPLQPEAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQTLQGLAFPLQPEAQR 17 0 D6RG15;Q6IBS0;H0Y858 D6RG15;H0Y858 TWF2 Twinfilin-2 0 25128100.0 6143100.0 8599000.0 10386000.0 False True 8414370.081035359 8219067.746909622 7933040.706384309 1.0 0.9767894290071795 0.9427967429509798 23.004423841475678 -6.965652654813468 0.3466834354678888 1.003412909153977 0.9150320691361442 0.9999258978825698 0.00020213421877800656 0.07774034334939509 0.01408390656666396 0.00047068732710374466 0.002928303281817729 1.0822992193280553e-07 6.965652654813468 -0.08838084001783275 HQTLQGLAFPLQPEAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HQTLQGLAFPLQPEAQR 17 0 D6RG15;Q6IBS0;H0Y858 D6RG15;H0Y858 TWF2 Twinfilin-2 0 15364000.0 7483000.0 4811700.0 3069300.0 False True 6222446.0531078605 4785778.417052334 3711076.4391602287 1.0 0.7691152926367326 0.596401544904788 22.56905038681636 -6.974322110183258 0.11495890244230077 1.335813396724882 0.0252810568211222 0.9999995390322882 0.00011210692101771872 0.07492346974497716 0.003410184496844741 0.012911758489931889 0.025639468865041967 1.0609084043011284e-07 6.974322110183258 -1.3105323399037598 HQTLVLTLPTVAFLEDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQTLVLTLPTVAFLEDK 17 0 K7ES61;Q9BYD3 K7ES61 MRPL4 39S ribosomal protein L4, mitochondrial 0 29483000.0 8512000.0 10115000.0 10856000.0 False True 12913326.310555175 8309899.221144275 8710306.84164616 1.0 0.6435134543414951 0.6745207727405197 23.622357332837073 -9.8823497987496 5.470683327048416 1.0000002620728436 0.6590171139463473 0.9938363286454832 0.012658684735283704 4.0455775622307674e-08 8.279518838112407e-09 0.012256728102584285 0.004085572929370653 1.3111434244346268e-10 9.8823497987496 -0.3409831481264963 HQTLVLTLPTVAFLEDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HQTLVLTLPTVAFLEDK 17 0 K7ES61;Q9BYD3 K7ES61 MRPL4 39S ribosomal protein L4, mitochondrial 0 7357500.0 3618300.0 2045300.0 1693900.0 False True 3008776.767868531 2034281.5629397377 2048086.6582913098 1.0 0.6761158171202105 0.6807040921624138 21.520745641154615 -10.032590061491353 5.483302943639352 1.0000015947801777 0.678409954641045 0.9998473514147813 0.0018731554430970296 3.651895869249891e-08 6.444412467729327e-09 0.001813683943958458 0.0006045583195281908 9.277050880339212e-11 10.032590061491353 -0.32159164013913266 HQTLVLTLPTVAFLEDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HQTLVLTLPTVAFLEDK 17 0 K7ES61;Q9BYD3 K7ES61 MRPL4 39S ribosomal protein L4, mitochondrial 0 20535400.0 8512000.0 8476100.0 3547300.0 False True 11018951.796604544 8004397.583909286 2901727.798371666 1.0 0.7264209637776814 0.2633397306689212 23.393483654929522 -7.074757219526834 0.4144020138098378 1.023343850448679 2.8944351796460356e-16 0.9998118791700831 0.004170109812403532 0.07443427083293501 0.020033464623841462 0.006476035468972339 0.03674016608811309 8.418656321228587e-08 7.074757219526834 -1.0233438504486787 down HQYYNQEWTLWDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HQYYNQEWTLWDR 13 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 23330900.0 6791900.0 7318100.0 9220900.0 False True 8904246.672853164 6226268.005730374 8266809.72111849 1.0 0.6992470261086452 0.9284120290964017 23.086062129296565 -10.517101697907316 5.50757004743061 1.0004076754658955 0.8138295276025231 0.4680742563610666 0.09355622070389871 0.0004693398869140365 4.115115163744916e-05 0.09078136384018184 0.030195140393358647 3.040173030818461e-11 10.517101697907316 -0.18657814786337235 HQYYNQEWTLWDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HQYYNQEWTLWDR 13 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 18007200.0 3382600.0 4120200.0 10504400.0 False True 3275221.2145416313 5765417.346559156 7752982.514754848 1.0 1.760313874666334 2.367163011869988 21.643160921575518 -6.9736741266003435 0.1457627244091324 0.2512287872262368 3.8921519786075005 0.9999987169367618 0.0006335206756227008 0.07512751329074664 0.004437576417672643 0.03232200326172645 0.07705386742226406 1.0624925007247323e-07 6.9736741266003435 3.6409231913812636 HQYYNQEWTLWDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HQYYNQEWTLWDR 13 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 44576000.0 15897200.0 15960400.0 12718400.0 False True 24117214.640995998 13112141.920825621 10204602.665327262 1.0 0.5436839251966002 0.4231252579218174 24.523559960518263 -13.999999999999998 0.18684338637411166 3.4200496558481017 0.33383358923068807 0.9994914580302512 0.0056027448010280345 12.30102139432337 0.1370696136215871 10.827090858302215 0.08503949745548725 1.0000000000000041e-14 13.999999999999998 -3.0862160666174137 HQYYNQEWTLWDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HQYYNQEWTLWDR 13 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 22488400.0 6791900.0 9502300.0 6194200.0 False True 9303048.974196095 9082456.966095975 4731257.533553407 1.0 0.9762882030706301 0.5085706360007902 23.149272190819456 -6.917423689979199 0.8436110492709913 1.0113089818576384 0.43744160377577745 0.9934348623580884 0.018334478412793682 0.09971162638353895 0.11364346834144985 0.015585179259768317 0.04559487313935052 1.2094176714360885e-07 6.917423689979199 -0.573867378081861 HQYYNQEWTLWDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HQYYNQEWTLWDR 13 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 11601300.0 3382600.0 6762400.0 1456300.0 False True 2812781.7745880918 6725969.608968693 1760805.596829584 1.0 2.3912162933271475 0.6260014952946142 21.423566197009794 -6.696584577048307 1.8432122383733398 1.86676038350478 0.631598963757344 0.4013669879176921 0.5876230900140482 0.4026397080707674 2.657054971708908 0.25457946950693583 0.6574460362668275 2.0110155231348955e-07 6.696584577048307 -1.2351614197474359 HQYYNQEWTLWDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HQYYNQEWTLWDR 13 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 40538400.0 15897200.0 12743000.0 11898200.0 False True 20579238.78066047 12033840.848002743 9732849.68584157 1.0 0.5847563642301317 0.4729450777833486 24.294686282610712 -13.999999999999995 0.18414351440261903 3.1827875896586626 0.38782612625664714 0.9994937218737697 0.0051018804279441025 12.26118992375874 0.1360640684317082 9.585793508840055 0.08063307281046735 1.0000000000000123e-14 13.999999999999995 -2.7949614634020152 HRFEVNPVWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HRFEVNPVWK 10 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 38501500.0 9915400.0 6953100.0 21633000.0 False True 12999185.420870194 5915724.5829715235 19394624.678388927 1.0 0.45508425270046743 1.4919876938789451 23.631917885458254 -6.763913540939765 1.5977429411093336 0.6850264857494354 1.4965260089711907 0.7067368645241934 0.22934006940917917 0.2763916401099393 1.3914175242964426 0.11320902616409256 0.27101792644691586 1.7222113975743978e-07 6.763913540939765 0.8114995232217553 HRFEVNPVWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HRFEVNPVWK 10 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 23650000.0 6735400.0 3940600.0 12974000.0 False True 6521588.413771568 5514102.129957528 9575720.188342929 1.0 0.845515199688692 1.4683110280498513 22.636791962856456 -6.84105381025885 1.2774837278700335 0.9178262470586134 1.4892276063462884 0.9262542784240198 0.07190861233759897 0.16756962070270418 0.5307563701945576 0.04413024589997714 0.10169848993257742 1.4419366806084125e-07 6.84105381025885 0.571401359287675 HRFEVNPVWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HRFEVNPVWK 10 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 27172900.0 9915400.0 7053500.0 10204000.0 False True 13581391.333609736 6741853.047194681 7794025.357976647 1.0 0.4964037101641187 0.5738753244440317 23.695127946981145 -10.703235346138399 6.804652664220117 1.0044457212993618 0.5351395173041396 0.9795944848851204 0.03162765408925026 0.0021431212264206314 9.346570094324044e-05 0.030766799438083244 0.0102077814639396 1.9804535182687423e-11 10.703235346138399 -0.46930620399522227 HRFEVNPVWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HRFEVNPVWK 10 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 47422000.0 12574000.0 17721000.0 17127000.0 False True 16277290.870595101 16734810.771989034 14010061.737860238 1.0 1.0281078654323517 0.8607121325803295 23.95635726720679 -6.8637261760492345 1.166852230131877 1.0154274312023528 0.8520131785224778 0.9580057938435041 0.01499868551051906 0.143007648518222 0.36790898431507696 0.010009664191731868 0.023471097648922246 1.3685914545677495e-07 6.8637261760492345 -0.16341425267987497 HRLDLGEDYPSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HRLDLGEDYPSGK 13 1 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 4743000.0 1081000.0 1668500.0 1993500.0 False True 1417201.4684188906 1419566.3037620601 1787231.7430022797 1.0 1.00166866560321 1.261099274047617 20.43461343472761 -6.908309146518596 0.9071518854909727 0.9915315663309302 1.2934436859342144 0.9902681104572002 0.01210360229347893 0.1055475397772124 0.1449033560144297 0.009827254955191348 0.026820831975565236 1.2350679544226348e-07 6.908309146518596 0.30191211960328423 HRLDLGEDYPSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HRLDLGEDYPSGK 13 1 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 6285600.0 1081000.0 2202600.0 3002000.0 False True 1480674.91292657 2105281.8489758237 2292989.428130723 1.0 1.4218393454203335 1.5486109801094723 20.4978234962505 -11.969071401125417 0.20124896556666708 1.1627057485198495e-22 1.639130987059613 0.9994013487354776 0.005738061788741646 5.171473025582502 0.1254299625958431 2.241381091740004 0.07943172898386656 1.0738128552985845e-12 11.969071401125417 1.639130987059613 HRLDLGEDYPSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HRLDLGEDYPSGK 13 1 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 7473300.0 2203000.0 2283100.0 2987200.0 False True 2851826.9276221585 2156043.4779938026 2443560.251260351 1.0 0.7560218529079893 0.856840303874184 21.443454999129216 -10.181146172240727 4.695799296492788 1.0000276478946075 0.8064310783897671 0.8309403711037133 0.04115896025868854 1.1915134643387067e-05 2.0777975831300323e-06 0.03985768060453751 0.013283997301785574 6.589520717669717e-11 10.181146172240727 -0.1935965695048404 HRPELIEYDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HRPELIEYDK 10 1 O43707;K7EJH8 O43707 ACTN4 Alpha-actinin-4 0 5059880.0 1427600.0 970680.0 2661600.0 False True 1382281.6194287313 1358277.5860293296 1964447.1137115413 1.0 0.9826344841297087 1.421162725525792 20.39862014276565 -6.897679808985133 0.9758292054524914 0.9805887576300986 1.4650833319448746 0.9853758589956341 0.024519235577738347 0.11313311204419553 0.18721271938576173 0.01892442284396506 0.048688720578471026 1.2656691397331225e-07 6.897679808985133 0.48449457431477605 HRPLNLGPFVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HRPLNLGPFVVR 12 1 Q9BYD6 Q9BYD6 MRPL1 39S ribosomal protein L1, mitochondrial 0 26791300.0 8817400.0 6408900.0 11565000.0 False True 11559696.787823062 5452717.101696536 10368364.739313455 1.0 0.47170070303577566 0.896940891238207 23.462600220489485 -9.968365129687868 6.9301669872711384 1.000000022379174 0.684320797136993 0.423560700000875 0.1736035798701769 6.00535185974918e-08 9.035679193513171e-09 0.1680909559435247 0.05603031447326495 1.075560564265148e-10 9.968365129687868 -0.31567922524218106 HRPLNLGPFVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HRPLNLGPFVVR 12 1 Q9BYD6 Q9BYD6 MRPL1 39S ribosomal protein L1, mitochondrial 0 19757600.0 5459600.0 3047000.0 11251000.0 False True 5286287.986433952 4263682.989895092 8304025.577234954 1.0 0.8065551859521953 1.5708613678530823 22.33382359159513 -6.8396352666238975 1.2842382747666155 0.8970909365309591 1.5957952824887287 0.9238001272688864 0.08956493948545154 0.1692269601824313 0.5423374897821419 0.054692218299965185 0.12597765306467962 1.446654203787668e-07 6.8396352666238975 0.6987043459577696 HRPLNLGPFVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HRPLNLGPFVVR 12 1 Q9BYD6 Q9BYD6 MRPL1 39S ribosomal protein L1, mitochondrial 0 24100100.0 8817400.0 9271200.0 6011500.0 False True 12077431.061275434 8861567.72824147 4591707.510728803 1.0 0.7337295227173622 0.3801890888412074 23.525810282012376 -6.96720503004647 0.31794369999099287 1.0496005685173702 0.05294921636653951 0.9999516481314101 0.0017652985092930036 0.07722047817455283 0.012262236337280935 0.0054043564982330285 0.031155379667559824 1.0784374726400411e-07 6.96720503004647 -0.9966513521508307 down HRPLNLGPFVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HRPLNLGPFVVR 12 1 Q9BYD6 Q9BYD6 MRPL1 39S ribosomal protein L1, mitochondrial 0 14750600.0 5459600.0 5212200.0 4078800.0 False True 4539899.301289286 5184120.844059304 4931658.221759601 1.0 1.1419021656685349 1.0862924251115127 22.114228867029407 -10.39637079339949 5.211544327348199 0.9999184568222094 1.1140972953895332 0.848780522066547 0.022702581515558967 2.152721326421732e-05 2.493414190281698e-06 0.021997371104118212 0.007327226677137401 4.014479149429864e-11 10.39637079339949 0.1141788385673238 HRPQLLVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 HRPQLLVER 9 1 P47897;P47897-2;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9;A0A0U1RQU2;A0A0U1RQL2 P47897 QARS Glutamine--tRNA ligase 0 7385270.0 971170.0 3317600.0 3096500.0 False True 1273213.2748236584 2822627.011903515 2776103.8837253833 1.0 2.216931811596492 2.180391878265546 20.28004267336982 -10.538933261294064 6.323664153618403 0.9985443284836248 2.198661844930931 0.9993035324449887 0.014917365316022854 0.00030637918510774425 2.233848375922682e-05 0.014454690141175655 0.004814558953187307 2.8911241317552313e-11 10.538933261294064 1.2001175164473061 HRPQLLVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 HRPQLLVER 9 1 P47897;P47897-2;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9;A0A0U1RQU2;A0A0U1RQL2 P47897 QARS Glutamine--tRNA ligase 0 4326500.0 1185200.0 1081600.0 2059700.0 False True 1147576.4747456787 1513488.5204694867 1520202.78032449 1.0 1.3188563496867605 1.3247071666063834 20.13015886767791 -11.793302419456433 0.6171128108275076 1.558065775168123e-06 1.3239278811959054 0.9999686608488236 0.0008492637338558408 6.409521541319511 0.30892250041109504 8.54751710240278 0.0009966782023855037 1.6095244580847843e-12 11.793302419456433 1.3239263231301304 HRPQLLVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HRPQLLVER 9 1 P47897;P47897-2;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9;A0A0U1RQU2;A0A0U1RQL2 P47897 QARS Glutamine--tRNA ligase 0 6965870.0 971170.0 3588600.0 2406100.0 False True 1330237.7938824215 3430043.786086739 1837828.7351849906 1.0 2.578519270660504 1.3815791008471638 20.34325273489271 -6.575857911262945 2.2832258887174914 2.0776020048135737 1.384342195698546 0.0 0.6864749775711848 0.7119080633276338 6.974667988065601 0.2531185043746366 0.7682062176352248 2.655474215105956e-07 6.575857911262945 -0.6932598091150277 HRPQLLVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HRPQLLVER 9 1 P47897;P47897-2;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9;A0A0U1RQU2;A0A0U1RQL2 P47897 QARS Glutamine--tRNA ligase 0 3830680.0 1185200.0 1738900.0 906580.0 False True 985546.3132625197 1729532.2005553762 1096141.6864476854 1.0 1.7548969310533875 1.112217327280191 19.910564143112186 -10.219359614909854 4.338745748621942 0.9998221533199766 1.433557129179121 0.37764327328446645 0.2623728495979829 0.0004515519244145435 8.124455992118405e-05 0.2541448020033915 0.08468047307670155 6.034487403729923e-11 10.219359614909854 0.43373497585914433 HRPQVAIICGSGLGGLTDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HRPQVAIICGSGLGGLTDK 19 1 P00491;G3V5M2;G3V2H3 P00491 PNP Purine nucleoside phosphorylase 0 34125900.0 7515700.0 16022400.0 10587800.0 False True 9853155.482142344 13631920.374826021 9492276.021349149 1.0 1.3835080954047903 0.9633742244860293 23.232154392310004 -6.6664875833821355 1.9498340582594527 1.2455141728290982 0.9650915928056305 0.26376374187432927 0.1630361230230046 0.46911358743852627 3.434956137510711 0.0673974504211588 0.18089725411993227 2.1553232640653774e-07 6.6664875833821355 -0.28042258002346765 HRPQVAIICGSGLGGLTDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HRPQVAIICGSGLGGLTDK 19 1 P00491;G3V5M2;G3V2H3 P00491 PNP Purine nucleoside phosphorylase 0 31663300.0 7515700.0 16136300.0 8011300.0 False True 10294457.394155633 15423344.910391657 6119195.937902615 1.0 1.4982183440914327 0.5944165586985288 23.295364453832896 -6.75707190910397 1.6236000038161675 1.2904516505426402 0.5915990557250878 0.6788238177109298 0.20947311759343729 0.28788289232114356 1.4950023351484554 0.10183164791186819 0.2454197671812518 1.7495569785407797e-07 6.75707190910397 -0.6988525948175525 HSAPGLLSMANSGPSTNGCQFFITCSK ddPTM_RPMI8226_Bortezomib_1h_R1 2 HSAPGLLSMANSGPSTNGCQFFITCSK 27 0 C9JQD4;O43447;O43447-2;H0YEL5 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 0 35217200.0 7579900.0 18769700.0 8867600.0 False True 9937322.303856017 15969333.923717551 7950065.816025577 1.0 1.607005734081998 0.8000209284688977 23.24442572700976 -6.7054313468192195 1.8113166131734948 1.3748961831351871 0.8021447759610274 0.44348327400129817 0.2559785644425335 0.3843219515346489 2.454921094822573 0.11258237464397568 0.28762652191264226 1.9704646732409013e-07 6.7054313468192195 -0.5727514071741597 HSAPGLLSMANSGPSTNGCQFFITCSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HSAPGLLSMANSGPSTNGCQFFITCSK 27 0 C9JQD4;O43447;O43447-2;H0YEL5 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 0 50871000.0 10960000.0 22774000.0 17137000.0 False True 16627121.283327628 18709801.76592583 13749864.438586073 1.0 1.125258031568372 0.826953999089028 23.987035075183773 -6.792608137699764 1.4856541159273091 1.0697679156101068 0.8235378120869363 0.8097644114518188 0.05334320168087179 0.23146730019534573 1.0091574042922578 0.0282565405860086 0.06603896798352861 1.6120995706026833e-07 6.792608137699764 -0.24623010352317043 HSAPGLLSMANSGPSTNGCQFFITCSK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 HSAPGLLSMANSGPSTNGCQFFITCSK 27 0 C9JQD4;O43447;O43447-2;H0YEL5 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 0 42281700.0 7579900.0 14231600.0 20470200.0 False True 10382393.869095387 13602800.854392247 15635560.357002508 1.0 1.3101796200279823 1.5059687153214143 23.30763578853265 -9.55267471919122 0.0782487308422798 3.914813788015818e-19 2.2983552688784474 0.9999781261146266 0.0009742533559686256 1.0464778576642733 0.031898906108987914 0.5710321159007369 0.3612914726836438 2.801078504815917e-10 9.55267471919122 2.2983552688784474 HSAPGLLSMANSGPSTNGCQFFITCSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSAPGLLSMANSGPSTNGCQFFITCSK 27 0 C9JQD4;O43447;O43447-2;H0YEL5 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 0 35709000.0 10960000.0 10731000.0 14018000.0 False True 14187936.053898713 10133810.416692885 11466867.836826343 1.0 0.7142554335031844 0.8082125400949601 23.758161397276222 -10.638484627465395 9.418565979972751 1.000093975818907 0.7612339867990723 0.8959463046016638 0.03835782814302338 7.572270055922873e-05 2.90650069864939e-06 0.03715427076128971 0.012379935799551312 2.2988750801143282e-11 10.638484627465395 -0.23885998901983463 HSAQTEEPVQAK(ub)VFSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HSAQTEEPVQAKVFSR 16 1 A0A5H1ZRS1;Q15154-5;Q15154;H0YBA1 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 6130400.0 1922600.0 1790000.0 2417800.0 True False 1861568.1153780343 2504756.3347266833 1784505.6475547662 1.0 1.3455088288391934 0.9586034659775966 20.828086975156477 -6.671249062074127 1.9331101243981954 1.2203042586820072 0.9601651789516035 0.28449062171829265 0.1467233858579927 0.45827450713316187 3.30283855570005 0.0610802528592523 0.16291598393180168 2.1318219911291403e-07 6.671249062074127 -0.26013907973040373 HSAQTEEPVQAK(ub)VFSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HSAQTEEPVQAKVFSR 16 1 A0A5H1ZRS1;Q15154-5;Q15154;H0YBA1 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 6578400.0 1922600.0 3502300.0 1153500.0 True False 1598727.0856214343 3483432.414747884 1394691.5168185972 1.0 2.178878712994253 0.8723762356703131 20.608492250590754 -6.669063142371591 1.941180192879883 1.7531059956651005 0.8777364808903829 0.2746896085418876 0.5008753596364675 0.4632755512022734 3.3648019717645132 0.2078158570828025 0.5558126770293823 2.1425790674383581e-07 6.669063142371591 -0.8753695147747176 HSATFSSIVK(ub)GQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSATFSSIVKGQR 13 1 Q66K74-2;Q66K74;M0QXQ9;M0QY41 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 3626580.0 770180.0 1421700.0 1434700.0 True False 1054936.3593319033 1358884.5930667992 1095853.4085740005 1.0 1.2881199714524845 1.0387862726316592 20.008724538071213 -10.016999526570913 7.626746833667888 0.9999999971054288 1.1634531220420719 0.36427667424102594 0.10179005629863361 8.943413852043925e-09 1.1553752421882305e-09 0.09855780261940716 0.03285259940451028 9.616133266481253e-11 10.016999526570913 0.1634531249366431 HSATFSSIVK(ub)GQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSATFSSIVKGQR 13 1 Q66K74-2;Q66K74;M0QXQ9;M0QY41 Q66K74-2 MAP1S Microtubule-associated protein 1S;MAP1S heavy chain;MAP1S light chain 1 7699660.0 646760.0 1527100.0 5525800.0 True False 837243.5695455786 1442115.5425712133 4520161.099496003 1.0 1.7224563974303613 5.398860336364675 19.675287864783158 -6.939413383400503 0.6649977564844913 0.9582873427108625 6.373394327637271 0.9980860622205756 0.08426300694872041 0.08803525678981257 0.055835869535753944 0.08166369007438065 0.31724730899619435 1.1497055202281181e-07 6.939413383400503 5.415106984926409 HSATPFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSATPFLK 8 0 P08243-2;P08243;P08243-3;F8WEJ5;C9J057 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 5335030.0 873610.0 2025700.0 2435720.0 False True 1145311.1700512744 1723473.4561167571 2183695.059476052 1.0 1.5048080392332148 1.9066391008639951 20.127308187297242 -6.973701920360952 0.14458235312280565 0.49583885565107483 2.9261288237885448 0.9999987617417878 0.000412718290981946 0.07511872538438655 0.004396811287143532 0.021661619517995445 0.05128102246529 1.0624245060379012e-07 6.973701920360952 2.43028996813747 HSATPFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSATPFLK 8 0 P08243-2;P08243;P08243-3;F8WEJ5;C9J057 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 4243410.0 873610.0 1806500.0 1563300.0 False True 1196607.2254225546 1726682.8567033655 1194080.737174139 1.0 1.4429821415240298 0.9978886236061932 20.190518248820133 -10.629176317454814 3.264717298536315 0.9864438899550932 1.2204353821596545 0.24644232458941262 0.18170866824364362 134164232.97407204 117599364.1445174 14978163.334730137 0.06649855096310368 2.348679096564049e-11 10.629176317454814 0.23399149220456128 HSDPELLK(ub)QK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HSDPELLKQK 10 1 A0A5F9ZHU7;P49643 A0A5F9ZHU7 PRIM2 DNA primase large subunit 1 8346300.0 1745700.0 2304600.0 4296000.0 True False 2648354.5277650617 1893326.124078016 3446893.716996314 1.0 0.714906597371534 1.3015227685188875 21.336664833921002 -6.774503719629229 1.5568416985504763 0.8374288715794556 1.3054321782681415 0.7476682910885715 0.12031536382104689 0.25917934372132884 1.2402531007220738 0.0608895762180565 0.14437422364225455 1.6807235306486944e-07 6.774503719629229 0.46800330668868595 HSDPELLK(ub)QK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSDPELLKQK 10 1 A0A5F9ZHU7;P49643 A0A5F9ZHU7 PRIM2 DNA primase large subunit 1 7549100.0 1745700.0 1527000.0 4276400.0 True False 2259843.062891516 1442021.1076591206 3498139.079569422 1.0 0.6381067479146205 1.547956642216332 21.10779115601345 -6.798784714604644 1.4609717035112457 0.8000203090585275 1.5601289450542295 0.8285639524957037 0.15486429968220167 0.22249338137534128 0.9377041491228646 0.08339754259189487 0.19408847415291866 1.5893344069902666e-07 6.798784714604644 0.760108635995702 HSEVQQANLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HSEVQQANLK 10 0 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 0 4938300.0 1458300.0 1272100.0 2207900.0 False True 1412007.0647330605 1780056.1639138644 1629584.75441979 1.0 1.2606566980954754 1.1540910772481598 20.429315876226365 -10.112951885316074 4.352438964088873 0.9999725576514139 1.2073738876286546 0.8346857244744988 0.04350523259187579 30322235.879078977 0.6617281683128354 8682.369430453373 0.014892998278802016 7.709888807678665e-11 10.112951885316074 0.2074013299772407 HSEVQQANLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HSEVQQANLK 10 0 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 0 3312210.0 1458300.0 1149300.0 704610.0 False True 1212641.063643885 1143108.4927818128 851940.6932514539 1.0 0.9426602207803084 0.7025497641416194 20.20972115166064 -6.943823583828627 0.6229795064436089 1.0026233766020691 0.6298008583212497 0.9986230154434095 0.0047812750984858494 0.08606485079198478 0.04698617292834819 0.004802101566918794 0.020343680083802787 1.1380894989685549e-07 6.943823583828627 -0.37282251828081947 HSFFSTIDWNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HSFFSTIDWNK 11 0 B4DG22;B1AXG1;B7ZB17;P51812 B4DG22 RPS6KA3 Ribosomal protein S6 kinase alpha-3 0 14213100.0 3416100.0 5000500.0 5796500.0 False True 5182473.450362733 4108121.705915172 4650819.234303796 1.0 0.7926951763983732 0.8974130362362541 22.3052093897996 -10.17052757129334 4.6622915155608275 1.0000210347612666 0.8450541063159107 0.7448430446819931 0.04275088726465251 9.348532193310287e-06 1.6632318556262475e-06 0.041398985933866525 0.013797789533620075 6.752621834463871e-11 10.17052757129334 -0.15496692844535587 HSFFSTIDWNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSFFSTIDWNK 11 0 B4DG22;B1AXG1;B7ZB17;P51812 B4DG22 RPS6KA3 Ribosomal protein S6 kinase alpha-3 0 12598900.0 4562900.0 3092800.0 4943200.0 False True 6249927.437736032 2956149.869478091 3775717.9683996653 1.0 0.4729894705063847 0.6041218887762605 22.575408009366726 -10.142332712867661 7.837801977284251 1.0000000874768127 0.5385556796413926 0.9428910329735379 0.05353458558306904 8.179124033509859e-08 8.967832103914724e-09 0.05183464964335823 0.01727821320077852 7.205552505252385e-11 10.142332712867661 -0.46144440783542007 HSFFSTIDWNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSFFSTIDWNK 11 0 B4DG22;B1AXG1;B7ZB17;P51812 B4DG22 RPS6KA3 Ribosomal protein S6 kinase alpha-3 0 15516200.0 3416100.0 6833400.0 5266700.0 False True 4422208.791398123 6453115.282958642 4308214.640905492 1.0 1.4592516064621246 0.974222349990718 22.07633571189205 -8.877005272179833 18.64547489068398 1.000007092852277 1.2167369782264212 0.2102586111959045 0.19801236482175494 0.0 0.0 0.19172464780531773 0.0639082159351059 1.327378343733122e-09 8.877005272179833 0.21672988537414417 HSFGLTEVK(ub)GK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSFGLTEVKGK 11 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 3022230.0 609780.0 729150.0 1683300.0 True False 799427.4851179207 620363.6622044384 1509128.2633537678 1.0 0.776009924293422 1.8877612934851267 19.60860764934887 -6.8542911966800215 1.2142717732778308 0.8798819732551172 1.9360055110919054 0.9463100192018268 0.11123958232499427 0.15280159771959348 0.43141071618719257 0.07159921802927618 0.16619804998145146 1.3986492066275118e-07 6.8542911966800215 1.0561235378367884 HSFGLTEVK(ub)GK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HSFGLTEVKGK 11 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 5334000.0 343600.0 1044500.0 3945900.0 True False 332692.6060771314 1461574.2969955443 2912350.4155374123 1.0 4.393167357187052 8.75387779090652 18.343830277855094 -6.967698859804669 0.3082385548332414 0.3140680844296618 12.971238386046359 0.9999584607817756 0.020454863458355968 0.07705669425209868 0.011689223797000986 0.0695514216176333 0.38781446715648454 1.07721189444901e-07 6.967698859804669 12.657170301616697 HSFGLTEVK(ub)GK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HSFGLTEVKGK 11 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 3897700.0 343600.0 1926600.0 1627500.0 True False 285718.6240609201 1916221.0233998431 1967802.7252902186 1.0 6.7066717463656556 6.887204961727134 18.12423555328937 -10.020126569136021 0.7824478592985824 7.587044145232025e-12 6.850211165326418 0.9998766750154214 0.030358188231834223 1.306209870335133 0.4071068451176553 3.27584090684937 0.026298067517913783 9.547143071578024e-11 10.020126569136021 6.850211165318831 HSGASAEVQK(ub)EEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSGASAEVQKEEEK 14 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 15603800.0 3773700.0 5354100.0 6476000.0 True False 4947357.244562784 4555289.150118336 5805925.6421784535 1.0 0.9207520146487629 1.173540812836843 22.2382266483943 -6.8224591433964505 1.3612982086245569 0.9573894848270652 1.1793516391361125 0.889927525486013 0.035024024318727955 0.19030416460192043 0.6922896583579911 0.020215004087765404 0.04656233671926858 1.5050150976516173e-07 6.8224591433964505 0.2219621543090473 HSGASAEVQK(ub)EEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HSGASAEVQKEEEK 14 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 16545200.0 3160200.0 6103400.0 7281600.0 True False 4794254.4415667895 5014200.583918146 5842388.568361351 1.0 1.0458770273943734 1.2186229662128707 22.192875047323636 -6.946264796416549 0.5984525209078244 0.9980474629793733 1.2752719214369055 0.9988745619053742 0.0031577810421701607 0.08502128495654346 0.04244416202050008 0.0032459270975779666 0.014509839451091806 1.13171013074138e-07 6.946264796416549 0.2772244584575322 HSGASAEVQK(ub)EEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSGASAEVQKEEEK 14 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 16861600.0 3773700.0 5257200.0 7830700.0 True False 5168938.870407955 5024919.520764425 5981249.938328874 1.0 0.9721375405563342 1.1571523843261873 22.30143670991719 -6.8685370172689835 1.1417481981778324 0.9843718348274283 1.1676933971079912 0.963204212792167 0.015623499576663752 0.13826846155236372 0.3377810416325483 0.010628530202767952 0.025102616762907554 1.3535147183702993e-07 6.8685370172689835 0.18332156228056296 HSGASAEVQK(ub)EEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HSGASAEVQKEEEK 14 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 16084600.0 5270400.0 6000400.0 4813800.0 True False 4382571.118308121 5968074.6542138485 5820343.323503572 1.0 1.3617747420646094 1.3280659152772627 22.06334607187726 -10.356529069254908 5.265344954256351 0.9998588690149288 1.3449203286709517 0.9928876821822027 0.013761570909531768 2.2808427255072673e-05 2.787395027208061e-06 0.013329996330893686 0.004441527912514465 4.4001849446182946e-11 10.356529069254908 0.34506145965602286 HSGASAEVQK(ub)EEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSGASAEVQKEEEK 14 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 14233300.0 3160200.0 4775200.0 6297900.0 True False 4090941.1968549956 4509455.922261838 5151746.821911006 1.0 1.1023027966592591 1.259306006615673 21.964001369416085 -6.964874509931966 0.36020061339547266 0.9865020013710335 1.3804887860987842 0.9999105310600178 0.001008703011851186 0.07800359187429975 0.015010332503932246 0.002105577323951604 0.013408444975034076 1.0842401616484234e-07 6.964874509931966 0.3939867847277507 HSGASAEVQK(ub)EEEKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSGASAEVQKEEEKK 15 2 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 6787300.0 887510.0 3363190.0 2536600.0 True False 1163534.2046590666 2861415.1616119407 2274136.9647853435 1.0 2.4592445586508385 1.9545080459853783 20.150082191899557 -9.706042476184727 6.4180336130176645 0.9999999940812396 2.206876302319653 0.8840331783540382 0.20605781843590146 1.7765632134698872e-08 3.7058075341967765e-09 0.19951462776007048 0.06650487492902418 1.967693829941635e-10 9.706042476184727 1.2068763082384135 HSGASAEVQK(ub)EEEKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HSGASAEVQKEEEKK 15 2 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 8224450.0 1588400.0 1708950.0 4927100.0 True False 1537977.1114462027 2391342.647056516 3636544.700168368 1.0 1.5548623118375733 2.3644985826536935 20.552602602241098 -6.965711844878009 0.34561739855891677 0.917705688089053 3.0287925361471872 0.9999270760699309 0.004784549957923302 0.07772022209322203 0.014012824123073244 0.01124362122388636 0.06979755805719084 1.0821517226453989e-07 6.965711844878009 2.111086848058134 HSGASAEVQK(ub)EEEKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSGASAEVQKEEEKK 15 2 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 7127180.0 887510.0 2102400.0 4137270.0 True False 1215646.4310559311 2009509.016292917 3160132.035750304 1.0 1.6530374004778867 2.5995486475498963 20.21329225342245 -6.965821249139723 0.343665991747899 0.9016006286845676 3.382616260334966 0.9999290871447329 0.005529769996706991 0.07768336900956395 0.013883419428649804 0.013216944998491572 0.08170883945919495 1.0818791493011761e-07 6.965821249139723 2.4810156316503984 HSGFCLETQNWPDAVNQPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSGFCLETQNWPDAVNQPR 19 0 Q96C23;B8ZZ75 Q96C23 GALM Aldose 1-epimerase 0 11719100.0 3327400.0 3442300.0 4949400.0 False True 4362253.622587437 2928722.2579803034 4437283.565997227 1.0 0.6713782625603402 1.0171998122762258 22.056642220415213 -11.035351526313905 12.148572573271185 1.4185908917537613 0.8442890374166196 0.21279478175120892 0.14118105647707413 0.043989275476434414 0.0001280059486185879 0.0037567869163531 0.04556599004463973 9.218249822161512e-12 11.035351526313905 -0.5743018543371416 HSGFCLETQNWPDAVNQPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSGFCLETQNWPDAVNQPR 19 0 Q96C23;B8ZZ75 Q96C23 GALM Aldose 1-epimerase 0 13332700.0 3327400.0 4295400.0 5709900.0 False True 4557629.699603952 4105615.025011694 4361339.219081815 1.0 0.9008224220955168 0.9569314548439086 22.119852281938105 -10.20594380701584 4.42386579919621 1.0000218379766825 0.9288769384682181 0.6817686321945615 0.02290641670417324 4.935232736988207e-06 8.858583296809839e-07 0.022185851527140286 0.007393014200670851 6.223808092695573e-11 10.20594380701584 -0.07114489950846448 HSGNITFDEIVNIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSGNITFDEIVNIAR 15 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 9545700.0 2946600.0 4871800.0 1727300.0 False True 3863021.1349149942 4144946.4301276593 1548575.5654315685 1.0 1.0729805210394918 0.4008716264674656 21.881298140022064 -6.880005710862172 1.0798207929212216 1.0452294447816552 0.35324459837666095 0.9736877285797446 0.04884341343093836 0.12762256379184692 0.27228478450488625 0.03484504171844465 0.08426169862033975 1.3182394039289655e-07 6.880005710862172 -0.6919848464049942 down HSGNITFDEIVNIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HSGNITFDEIVNIAR 15 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 34050400.0 9249400.0 10160000.0 14641000.0 False True 8955782.859865576 14216940.983700054 10806082.87941488 1.0 1.5874593216648674 1.20660393943239 23.094388118640993 -10.118665352815828 4.447630521667971 0.9999527977320609 1.3970316305672497 0.5916702751407168 0.15548355877189288 108430008.39209051 4.836671163672588 53023.46115731548 0.05322615777869434 7.609123748844461e-11 10.118665352815828 0.39707883283518874 HSGNITFDEIVNIAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HSGNITFDEIVNIAR 15 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 88045000.0 11112000.0 56274000.0 20659000.0 False True 16857716.396016106 46231465.029231146 16575739.594838617 1.0 2.7424512278636257 0.9832731317484895 24.006905781317275 -6.648327718329318 2.014178741862332 2.1321370799012587 0.9906092710951084 0.1874606045363182 0.7439966770169801 0.5126127131390736 3.984126543698161 0.2997448575753117 0.8241774711674337 2.2473581108825568e-07 6.648327718329318 -1.1415278088061502 HSGNITFDEIVNIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HSGNITFDEIVNIAR 15 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 21799100.0 9249400.0 7738100.0 4811600.0 False True 7691285.917896008 7696413.319407401 5817683.313675225 1.0 1.000666650748149 0.7563993038067531 22.87479339407527 -6.906284582446385 0.9206756281133188 1.0084800547447363 0.7272185011394354 0.9894420585443701 0.011815630703385606 0.10692617933239039 0.15247805610335494 0.009499310406996923 0.025593749879951937 1.2408389500212473e-07 6.906284582446385 -0.2812615536053009 HSGNITFDEIVNIAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSGNITFDEIVNIAR 15 0 P30050;P30050-2 P30050 RPL12 60S ribosomal protein L12 0 57880000.0 11112000.0 29052000.0 17716000.0 False True 14384703.050266644 27435230.661239512 14491869.781510564 1.0 1.9072504010245075 1.007450048212287 23.778032103409725 -6.644308759137002 2.029507214839417 1.591351579040068 1.011256702976368 0.171175526436947 0.38777200628077796 0.5225287606253143 4.118763270941664 0.15533593253166483 0.42926637856622335 2.2682516781701306e-07 6.644308759137002 -0.5800948760637001 HSGPNSADSANDGFVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSGPNSADSANDGFVR 16 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 24174300.0 3729300.0 11648000.0 8797000.0 False True 4889148.414592572 9910163.803548373 7886770.826782569 1.0 2.0269713584414104 1.6131174916357698 22.22115176966855 -10.11933128854062 4.653051648380511 0.9999345319117395 1.8200444248638137 0.8396159369486362 0.16895513367133422 117832472.59485646 11.248349022587332 82653.16263386744 0.057837836191900284 7.597465059662811e-11 10.11933128854062 0.8201098929520741 HSGPNSADSANDGFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HSGPNSADSANDGFVR 16 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 5860890.0 758090.0 3034800.0 2068000.0 False True 734024.8479074867 4246611.466272925 1526328.7613298264 1.0 5.785378353851244 2.0793965840270823 19.485469375851547 -6.581638371327411 2.260295474478239 4.255406315503018 2.088736254910742 0.0 2.078027461555915 0.6943615573176104 6.674641322140432 0.7711538445870216 2.3221057652711563 2.620364026836606e-07 6.581638371327411 -2.166670060592276 HSGPNSADSANDGFVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HSGPNSADSANDGFVR 16 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 38338100.0 14270600.0 14870000.0 9197500.0 False True 21649543.52060723 12216332.320159713 7379610.093592551 1.0 0.5642766697843552 0.3408667756236168 24.36783327034141 -10.2782525789925 0.14460984011781938 1.7857793206332557 3.3092249337626263e-11 0.9997409805888883 0.004405005364829574 1.9647561857305926 0.07188278215778263 0.7702698010995593 0.20820047401197317 5.269233217906758e-11 10.2782525789925 -1.7857793206001635 HSGPNSADSANDGFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSGPNSADSANDGFVR 16 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 26566000.0 3729300.0 13030500.0 9806200.0 False True 5108122.990543069 12454769.4238988 7490177.525028478 1.0 2.438228180284021 1.4663267777411446 22.28436183119144 -10.484585929685219 5.638124408179113 0.998817518262444 1.9522774790125643 0.5614099587094522 0.3967770860875639 0.005903555705487312 0.0005396767345593064 0.38456345632500955 0.12805925388115288 3.2765294084520453e-11 10.484585929685219 0.9534599607501203 HSGPNSADSANDGFVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HSGPNSADSANDGFVR 16 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 7000290.0 758090.0 4120100.0 2122100.0 False True 630385.4240813238 4097904.2035241774 2565821.2985182023 1.0 6.5006328620242995 4.070242109828978 19.265874651285824 -9.40300940222273 9.189976264562993 0.9999886328607156 5.285437485932728 0.8056554045256955 0.9922028697648498 0.0 0.0 0.9606962976547098 0.32023209921823653 3.953580607035991e-10 9.40300940222273 4.285448853072012 HSGPNSADSANDGFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSGPNSADSANDGFVR 16 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 32642100.0 14270600.0 7681900.0 10689600.0 False True 18473573.015580926 7254395.512067198 8744202.484558336 1.0 0.39269043979465784 0.473335747079535 24.13895959243386 -10.651095103872562 6.646695689507009 1.0027196208399805 0.43301309343772715 0.9850537125199009 0.03292330883298403 0.0013308967895539114 6.986265687157377e-05 0.03197525488431177 0.01062595223434923 2.2330831581058692e-11 10.651095103872562 -0.5697065274022532 HSGSSHLPQQLK(ub)FTTSDSCDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HSGSSHLPQQLKFTTSDSCDR 21 1 Q08117;K7ELQ8 Q08117 AES Amino-terminal enhancer of split 1 56637600.0 3804600.0 12064000.0 40769000.0 True False 5771856.353517178 9911084.943537787 32710989.280312505 1.0 1.7171399176450917 5.667325601473001 22.460603964675254 -6.937670705409826 0.680886654261964 0.953367850131624 6.663335901829128 0.9978426449279139 0.09531728913333931 0.08884548018131244 0.05956997649128844 0.09122194767058242 0.3436191254505293 1.1543281709676569e-07 6.937670705409826 5.709968051697504 HSGSSHLPQQLK(ub)FTTSDSCDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSGSSHLPQQLKFTTSDSCDR 21 1 Q08117;K7ELQ8 Q08117 AES Amino-terminal enhancer of split 1 58285600.0 3804600.0 11982000.0 42499000.0 True False 4925129.699878014 11315191.166975504 34764618.07656456 1.0 2.297440241473389 7.058619812068221 22.231730286767704 -6.946856758858083 0.5923481710459468 0.9453392020610728 8.65126502723692 0.9989309605272291 0.08516294241885317 0.08477301405052912 0.041379155219232674 0.088079267748652 0.39915176234397853 1.1301686109766879e-07 6.946856758858083 7.705925825175848 HSIHWPCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSIHWPCR 8 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 5924800.0 1363400.0 2198000.0 2363400.0 False True 1787430.603184381 1870066.9677368954 2118858.039333629 1.0 1.0462319288957536 1.185421148971488 20.769455799810856 -6.9513714787340035 0.5435866843706941 0.9979977388011718 1.2401226390299347 0.999304507273661 0.0020782525358830897 0.08293979943917504 0.03372015050542505 0.0022747466739855434 0.011533627735394734 1.1184807689149938e-07 6.9513714787340035 0.24212490022876287 HSIHWPCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HSIHWPCR 8 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 13043000.0 6301600.0 3772200.0 2969200.0 False True 9559987.908669472 3099021.4376668804 2382336.318553409 1.0 0.3241658323496972 0.24919867486369812 23.18857736283212 -13.999999999999998 0.310461760951459 7.550510081810421 0.23267860988307215 0.999673010929594 0.006105688201706984 17.302679184969655 0.17730436535176833 73.23703162240649 0.02592971362700776 1.0000000000000041e-14 13.999999999999998 -7.317831471927349 HSIHWPCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSIHWPCR 8 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 5775800.0 1363400.0 2256600.0 2155800.0 False True 1867485.8244996169 2156895.950421708 1646644.4400946766 1.0 1.154973131321967 0.8817440103117711 20.832665861333748 -6.752829649756657 1.6391073213393357 1.0908173020271676 0.8810740571078011 0.6610858728710329 0.06513274779436856 0.29517505577526165 1.5610839144359325 0.03137719843023263 0.07595836831651165 1.7667306777114532e-07 6.752829649756657 -0.20974324491936658 HSIHWPCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSIHWPCR 8 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 10211900.0 6301600.0 0.0 3910300.0 False True 8157545.423106584 0.0 3198665.523066201 1.0 0.0 0.3921112733256561 22.95970368492457 -10.686709342906036 6.662305008598388 1.0065763978805111 0.19605563666283665 0.8485984959307128 0.16007875700680763 0.015605595969286276 0.0007338423332514987 0.15468619263631528 0.051665196664079135 2.057266987390653e-11 10.686709342906036 -0.8105207612176745 HSK(ub)LFEEPEDPSNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HSKLFEEPEDPSNR 14 1 P63151-2;P63151;A0A590UJY3;Q9Y2T4;Q9Y2T4-4;Q9Y2T4-2;Q9Y2T4-3;A0A590UJJ1;E5RFR9 P63151-2 PPP2R2A;PPP2R2C Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform;Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform 1 5793700.0 1335800.0 2242500.0 2215400.0 True False 1293395.7601799532 3137941.944483013 1635120.2794246115 1.0 2.4261266667879164 1.2642072363041559 20.30273235559933 -6.595427138011911 2.208357793174938 1.9619521357916831 1.2678279854014864 0.007505345030129118 0.6171420050902989 0.6538427173641715 6.019520689842001 0.23258356735813882 0.6869770578487491 2.5384748325178355e-07 6.595427138011911 -0.6941241503901967 HSK(ub)LFEEPEDPSNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HSKLFEEPEDPSNR 14 1 P63151-2;P63151;A0A590UJY3;Q9Y2T4;Q9Y2T4-4;Q9Y2T4-2;Q9Y2T4-3;A0A590UJJ1;E5RFR9 P63151-2 PPP2R2A;PPP2R2C Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform;Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform 1 5267300.0 1335800.0 2610100.0 1321400.0 True False 1110776.8859737394 2596038.873235717 1597698.6305367125 1.0 2.33713800315529 1.4383614303750327 20.083137631033605 -10.423247582681284 5.828215687032802 0.9996137637292757 1.8877497167651622 0.5653718523286038 0.3669239993465126 0.0018422293763440988 0.00018230481519392142 0.35541756270651703 0.11842421156607172 3.773570058408229e-11 10.423247582681284 0.8881359530358865 HSK(ub)LFEEPEDPSNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSKLFEEPEDPSNR 14 1 P63151-2;P63151;A0A590UJY3;Q9Y2T4;Q9Y2T4-4;Q9Y2T4-2;Q9Y2T4-3;A0A590UJJ1;E5RFR9 P63151-2 PPP2R2A;PPP2R2C Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform;Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform 1 15519300.0 3356300.0 0.0 12163000.0 True False 4344796.512563888 0.0 9949458.802919023 1.0 0.0 2.2899711814231303 22.050857179691928 -6.788007875552532 1.504244424027225 0.4396517740733919 2.313021281941066 0.7948213780244122 0.4245980114107322 0.23833181521479835 1.065400013245695 0.22220151492123152 0.5210017364939026 1.6292664870417794e-07 6.788007875552532 1.8733695078676742 HSLFIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSLFIR 6 0 A0A3B3IRL2;O75629 A0A3B3IRL2 CREG1 Protein CREG1 0 40727000.0 10947000.0 16758000.0 13022000.0 False True 14351623.010898806 14257771.722172381 11674608.35584434 1.0 0.9934605801270593 0.8134695530239675 23.774710563298598 -6.914592373627774 0.8638697784849962 1.0047965188281018 0.7877699570741914 0.992542400341535 0.00746396941846182 0.10145905251065596 0.12287197124190329 0.006253153621899973 0.017863640914160515 1.2173280418988303e-07 6.914592373627774 -0.21702656175391044 HSLFIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HSLFIR 6 0 A0A3B3IRL2;O75629 A0A3B3IRL2 CREG1 Protein CREG1 0 22073000.0 6421500.0 5051500.0 10600000.0 False True 6217652.997451392 7068590.293224497 7823542.006816319 1.0 1.1368582801455633 1.2582789695763303 22.567938672522068 -6.97253767843422 0.18793508759312771 0.9154539905439515 1.4829931977201396 0.9999960022543923 0.00021087093173059664 0.07548752804583726 0.005980996236346558 0.004363139874372192 0.013312856692563988 1.065276438617093e-07 6.97253767843422 0.5675392071761881 HSLFIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSLFIR 6 0 A0A3B3IRL2;O75629 A0A3B3IRL2 CREG1 Protein CREG1 0 39666000.0 10947000.0 10963000.0 17756000.0 False True 14994401.731551504 10478618.410207015 13562398.496298853 1.0 0.6988353785504965 0.9044974743981014 23.83792062482149 -10.086885929966241 5.065067619081633 1.0000047033977888 0.8016664273850733 0.5535720025807456 0.08396119904517808 4.45954309247451e-06 8.039940803656101e-07 0.08129700912201833 0.027098360468819457 8.186797910235212e-11 10.086885929966241 -0.19833827601271548 HSLLQTLYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSLLQTLYK 9 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 9379800.0 0.0 0.0 9379800.0 False True 0.0 0.0 8409268.273394914 0.0 HSLLQTLYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSLLQTLYK 9 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 17290000.0 0.0 7144000.0 10146000.0 False True 0.0 6828354.457951195 7749723.76342915 0.0 HSLLQTLYKV ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSLLQTLYKV 10 1 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 8686300.0 2620000.0 2961700.0 3104600.0 False True 3434845.372116094 2519825.904616179 2783365.7734260713 1.0 0.733606794958516 0.8103321902119082 21.711813723417773 -10.040035827049598 6.782588657199848 1.0000000702992744 0.7719694925852117 0.9217363074503372 0.0313230114473629 3.328683019134755e-08 4.697460781265284e-09 0.030328384686663882 0.010109458474058206 9.1193560627967e-11 10.040035827049598 -0.22803057771406265 HSLLQTLYKV ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSLLQTLYKV 10 1 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 8763500.0 2620000.0 4264100.0 1879400.0 False True 3588684.8028377593 4075697.9625069513 1435524.4274579878 1.0 1.1357079783892097 0.4000140737695448 21.775023784940664 -6.859078492009345 1.1903978110116993 1.0734544472322973 0.3650115943029892 0.9525130233828727 0.06965883051544157 0.14774931024692717 0.3983657673494929 0.04565814871443869 0.10647060492834416 1.38331634334739e-07 6.859078492009345 -0.7084428529293081 down HSLSGRPLK(ub)VK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSLSGRPLKVK 11 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 9253200.0 1672800.0 4777700.0 2802700.0 True False 2193056.999418241 4064885.7833287353 2512703.489396781 1.0 1.8535249126707787 1.1457538450041809 21.064511878695175 -10.115806009385118 4.229251647821006 0.9999126108328332 1.499639378898511 0.39920322210205583 0.2889463286521253 37097018.40649359 22182800.985772803 28773.57545877068 0.09891401425895019 7.659386599139603e-11 10.115806009385118 0.49972676806567773 HSLSGRPLK(ub)VK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HSLSGRPLKVK 11 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 22911040.0 2398600.0 664420.0 19848020.0 True False 3638851.561148687 545849.0598628457 15925050.147303794 1.0 0.15000586055522858 4.376394551877979 21.79505177017055 -6.854381198531142 1.21372481037241 0.5440770680514235 4.560225389907463 0.9464462355706014 0.42240104951489477 0.15270224024507123 0.430677691633491 0.2719844707361671 0.6314265844202521 1.3983593849046646e-07 6.854381198531142 4.016148321856039 up HSMNILNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSMNILNR 8 0 Q9NUU7;I3L0H8;F6QDS0;Q9UMR2;H3BQK0;Q9UMR2-4;Q9UMR2-2;Q9NUU7-2;I3L352;Q9UMR2-3 Q9NUU7 DDX19A;DDX19B ATP-dependent RNA helicase DDX19A;ATP-dependent RNA helicase DDX19B 0 16261100.0 5873200.0 5301500.0 5086400.0 False True 7602973.178080103 5006466.86460696 4160727.3908712724 1.0 0.6584880345285118 0.5472500419792269 22.858132270836933 -13.999999999999998 0.15685144856854194 2.671194140983892 0.4340076969984378 0.9995450059603305 0.004109091826807558 11.990173945612344 0.12504208960035043 6.098180788932613 0.10281782673457798 1.0000000000000041e-14 13.999999999999998 -2.237186443985454 HSNVNLTIFTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSNVNLTIFTAR 12 0 Q9NRW3;Q8IUX4;Q96AK3;Q6ICH2;A0A087WX48 Q9NRW3;Q96AK3 APOBEC3C;APOBEC3F;APOBEC3D;bK150C2.9 DNA dC->dU-editing enzyme APOBEC-3C;DNA dC->dU-editing enzyme APOBEC-3F;DNA dC->dU-editing enzyme APOBEC-3D 0 64281200.0 5017800.0 23548600.0 35714800.0 False True 6578384.392444321 20035240.671723876 32019375.096552648 1.0 3.045617202718586 4.867361526232622 22.64930188045745 -7.223465229444979 0.21492121189131866 5.423892129634728e-13 7.507966184818926 0.999981440565279 0.0068055586443309946 0.09817505888032976 0.011451201978639918 0.0960705656243834 0.2694420328719105 5.97770901603474e-08 7.223465229444979 7.507966184818383 HSNVNLTIFTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HSNVNLTIFTAR 12 0 Q9NRW3;Q8IUX4;Q96AK3;Q6ICH2;A0A087WX48 Q9NRW3;Q96AK3 APOBEC3C;APOBEC3F;APOBEC3D;bK150C2.9 DNA dC->dU-editing enzyme APOBEC-3C;DNA dC->dU-editing enzyme APOBEC-3F;DNA dC->dU-editing enzyme APOBEC-3D 0 48432200.0 14525600.0 8801900.0 25104700.0 False True 14064492.778911462 12316544.571302138 18529025.94514356 1.0 0.8757190724837068 1.3174329310280066 23.745554188528274 -6.831595521088094 1.3209562258540728 0.9336650709478099 1.329694924920684 0.9089923910045482 0.056107573646222625 0.17885246926274262 0.6098198979987804 0.03334570639121765 0.07672851149165189 1.4736843751769682e-07 6.831595521088094 0.39602985397287405 HSNVNLTIFTAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HSNVNLTIFTAR 12 0 Q9NRW3;Q8IUX4;Q96AK3;Q6ICH2;A0A087WX48 Q9NRW3;Q96AK3 APOBEC3C;APOBEC3F;APOBEC3D;bK150C2.9 DNA dC->dU-editing enzyme APOBEC-3C;DNA dC->dU-editing enzyme APOBEC-3F;DNA dC->dU-editing enzyme APOBEC-3D 0 104151100.0 26958100.0 38884000.0 38309000.0 False True 40897408.60110168 31944846.39792132 30737209.358568847 1.0 0.7810970790227721 0.7515686301390954 25.28550609621029 -13.999999999999998 0.282306785568516 2.8069157267466824 0.7428795466374759 0.9996102911220286 0.0021874863417490494 15.524320625670077 0.1683477039452632 16.217601541462173 0.011554091858017786 1.0000000000000041e-14 13.999999999999998 -2.0640361801092064 HSNVNLTIFTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSNVNLTIFTAR 12 0 Q9NRW3;Q8IUX4;Q96AK3;Q6ICH2;A0A087WX48 Q9NRW3;Q96AK3 APOBEC3C;APOBEC3F;APOBEC3D;bK150C2.9 DNA dC->dU-editing enzyme APOBEC-3C;DNA dC->dU-editing enzyme APOBEC-3F;DNA dC->dU-editing enzyme APOBEC-3D 0 56191700.0 5017800.0 24754100.0 26419800.0 False True 6873016.260946294 23660382.011137985 20179987.3728608 1.0 3.4425034239451024 2.936118089451802 22.712511941980342 -10.104618873306487 5.088939941210035 0.9999392192315425 3.18931075670346 0.9614234494125969 0.206730947140278 0.0001425652824243101 2.508364808482809e-05 0.20017183410438724 0.06672212628249984 7.859250415217332e-11 10.104618873306487 2.1893715374719176 HSNVNLTIFTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HSNVNLTIFTAR 12 0 Q9NRW3;Q8IUX4;Q96AK3;Q6ICH2;A0A087WX48 Q9NRW3;Q96AK3 APOBEC3C;APOBEC3F;APOBEC3D;bK150C2.9 DNA dC->dU-editing enzyme APOBEC-3C;DNA dC->dU-editing enzyme APOBEC-3F;DNA dC->dU-editing enzyme APOBEC-3D 0 28974500.0 14525600.0 10812200.0 3636700.0 False True 12078679.993187718 10753952.532546332 4397117.155799046 1.0 0.8903251463414444 0.364039543913655 23.52595946396255 -6.940727468410906 0.6527704436042152 1.0058414363213175 0.21903215783617982 0.9982575129432657 0.011587007869898998 0.08743658592333411 0.0531120944621276 0.011342154361865432 0.04515321655659944 1.146232007538099e-07 6.940727468410906 -0.7868092784851377 down HSNVNLTIFTAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSNVNLTIFTAR 12 0 Q9NRW3;Q8IUX4;Q96AK3;Q6ICH2;A0A087WX48 Q9NRW3;Q96AK3 APOBEC3C;APOBEC3F;APOBEC3D;bK150C2.9 DNA dC->dU-editing enzyme APOBEC-3C;DNA dC->dU-editing enzyme APOBEC-3F;DNA dC->dU-editing enzyme APOBEC-3D 0 88283100.0 26958100.0 39569000.0 21756000.0 False True 34897791.87359551 37366950.36605356 17796631.235411145 1.0 1.0707540036172394 0.5099643925860103 25.05663241830274 -6.875256669368258 1.105974491282347 1.0416138918521112 0.47367594107090694 0.969650796442578 0.043441152411907706 0.13191159766126787 0.2984191310914291 0.030376544240991045 0.0726470206683692 1.3327335497581572e-07 6.875256669368258 -0.5679379507812042 HSNVVILTTSNITEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSNVVILTTSNITEK 15 0 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 25211300.0 4472100.0 7579200.0 13160000.0 False True 5862966.407878007 6448412.90349021 11798329.439633809 1.0 1.0998549974336447 2.0123481218961987 22.48319936009802 -6.92770811986439 0.7653639046611032 0.9848813074054401 2.1891986992606074 0.9960685589184352 0.02856147793752113 0.0938448904660962 0.0836366908450292 0.02567482870396662 0.08362910611540622 1.181114170815451e-07 6.92770811986439 1.2043173918551673 up HSNVVILTTSNITEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSNVVILTTSNITEK 15 0 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 17189100.0 4472100.0 12717000.0 0.0 False True 6125556.223958297 12155120.890504656 0.0 1.0 1.9843293320798372 0.0 22.54640942162091 -6.778108857565123 1.584465655576661 1.562933077401319 8.586678730966351e-12 0.7372359300899467 0.41526528899691867 0.25905934658607893 1.2910687222797619 0.2078373991867297 0.4829851312673747 1.666829363060476e-07 6.778108857565123 -1.5629330773927324 HSPDTAEGQLK(ub)EDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSPDTAEGQLKEDR 14 1 Q6R327;Q6R327-3 Q6R327 RICTOR Rapamycin-insensitive companion of mTOR 1 9504700.0 1077500.0 1971600.0 6455600.0 True False 1394844.990700351 1861878.7268243101 5280747.040049654 1.0 1.3348284140802353 3.785902430203512 20.411673373404792 -6.931787211889842 0.7319764710350642 0.965085879550747 4.312783447162173 0.9968778723849188 0.06939312109240191 0.09172077202912779 0.07321250876675511 0.06390583251498898 0.21964170190835058 1.1700725425346907e-07 6.931787211889842 3.3476975676114256 up HSPEDPEATMTDQGPSK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSPEDPEATMTDQGPSKEK 19 1 P59047;A0A087WXM3;M0R0W4 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 14950400.0 1281400.0 0.0 13669000.0 True False 1658797.5601702395 0.0 11181382.255783943 1.0 0.0 6.740655113235407 20.66170639970523 -6.86916576577709 1.1385208381820038 0.43719639042850333 7.129168717609604 0.9638392583783664 0.5647868246860481 0.137660516083293 0.3340263816111822 0.3851819536084055 0.9106231445237222 1.351556589355476e-07 6.86916576577709 6.691972327181101 up HSQAVEELAEQLEQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSQAVEELAEQLEQTK 16 0 P35579 P35579 MYH9 Myosin-9 0 17298000.0 2249200.0 8782600.0 6266200.0 False True 2948722.981283781 7472270.314306669 5617833.733634755 1.0 2.5340699556163386 1.905175145068706 21.4916588636464 -10.417743847861635 5.660476829542983 0.999382881335388 2.219622550342378 0.8337370456101565 0.2567452312876765 0.0020004442412016417 0.00020577215402815067 0.24870203201467753 0.08286416708294364 3.821696126388597e-11 10.417743847861635 1.22023966900699 HSQAVEELAEQLEQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HSQAVEELAEQLEQTK 16 0 P35579 P35579 MYH9 Myosin-9 0 11702700.0 4364700.0 1767100.0 5570900.0 False True 4226144.987615984 2472712.2453047647 4111714.166582364 1.0 0.5850987726522959 0.9729231199192313 22.01091083241493 -10.528306050856358 9.07266605560578 1.0000116104507666 0.7790109462857636 0.302125532833191 0.15832862677198992 3.71850261893347e-05 1.93328419823963e-06 0.1533090785117006 0.05110034455965056 2.962742784726594e-11 10.528306050856358 -0.22100066416500297 HSQAVEELAEQLEQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSQAVEELAEQLEQTK 16 0 P35579 P35579 MYH9 Myosin-9 0 12315400.0 2249200.0 6003300.0 4062900.0 False True 3080790.0223445324 5738054.35574166 3103326.6980520734 1.0 1.8625269213819724 1.0073152261413747 21.55486892516929 -10.257665863154921 4.048401130399424 0.9995792523940005 1.434921073745015 0.25641481050763615 0.34913871273345104 248775755.39988312 208280829.29209343 1133885.8717959002 0.12777168188072174 5.52502359244273e-11 10.257665863154921 0.4353418213510146 HSQFIGYPITLFVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSQFIGYPITLFVEK 15 0 P07900;P07900-2;G3V2J8;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 252785000.0 57902000.0 122722000.0 72161000.0 False True 75910082.72376563 104412355.96660924 64694471.93718952 1.0 1.3754741428297803 0.8522513691970359 26.17778818792184 -6.71408612603197 1.780478789642242 1.229861847980427 0.8533179771782214 0.4845448444395324 0.15812568033631194 0.3669279350561945 2.2698476226381326 0.07060662316209124 0.17850162174862721 1.9315852215041434e-07 6.71408612603197 -0.37654387080220564 HSQFIGYPITLFVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HSQFIGYPITLFVEK 15 0 P07900;P07900-2;G3V2J8;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 311803000.0 123551000.0 87747000.0 100505000.0 False True 119628941.1333981 122784834.69455993 74179725.4146297 1.0 1.0263806862391494 0.6200817687745975 26.83399121367393 -6.8913936369629205 1.0140656394832857 1.0211070523835 0.5841621500793699 0.9817766654165646 0.025058344401307057 0.11802109775213022 0.2152834461291048 0.018792499994260237 0.04709294860499627 1.2841222262662704e-07 6.8913936369629205 -0.4369449023041301 HSQFIGYPITLFVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HSQFIGYPITLFVEK 15 0 P07900;P07900-2;G3V2J8;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 505943000.0 124363000.0 381580000.0 0.0 False True 188667763.15314543 313484067.70185256 0.0 1.0 1.6615666739388393 0.0 27.491272696016217 -6.812456077416561 1.4957314419930108 1.3647925721690222 1.2125239348308626e-18 0.8276999575430266 0.28350921908640325 0.21452405973645527 0.959884426481077 0.1510797145348518 0.3350732447066563 1.5400822751526593e-07 6.812456077416561 -1.3647925721690222 HSQFIGYPITLFVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSQFIGYPITLFVEK 15 0 P07900;P07900-2;G3V2J8;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 395989000.0 57902000.0 139152000.0 198935000.0 False True 79309934.14271443 133003804.52587135 151950650.1949318 1.0 1.6770131757585043 1.9159094234210798 26.240998249444733 -10.82249595714784 0.20893700311970448 3.617922975328788e-16 2.0918892094891284 0.9993392976037972 0.009971038386269797 2.7425058355754945 0.11205321589906968 1.49354998761294 0.13950567609293577 1.504887527752034e-11 10.82249595714784 2.091889209489128 HSQFIGYPITLFVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HSQFIGYPITLFVEK 15 0 P07900;P07900-2;G3V2J8;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 283222000.0 123551000.0 85980000.0 73691000.0 False True 102738130.73734191 85516808.67430633 89099447.39131291 1.0 0.8323765291480411 0.8672480874613403 26.614396489108206 -10.42651256346937 5.958918981284085 1.0000574472404173 0.8498123083046909 0.9611383473787874 0.014236254067215555 1.086927119608698e-05 1.0460498781923103e-06 0.013789457689086055 0.0045947312428919205 3.745307122836725e-11 10.42651256346937 -0.15024513893572644 HSQFIGYPITLFVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSQFIGYPITLFVEK 15 0 P07900;P07900-2;G3V2J8;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 247983000.0 124363000.0 123620000.0 0.0 False True 160990355.06122315 116740438.32928638 0.0 1.0 0.7251393307685486 0.0 27.262399018108667 -7.379824627845609 0.771686700358488 0.989963200118754 3.739598606580168e-18 0.9875946499171496 0.0469818198973491 0.11151923294012828 0.1384922790464806 0.04054236231566265 0.07245011505493054 4.170377532001227e-08 7.379824627845609 -0.989963200118754 down HSQFIGYPITLFVEK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSQFIGYPITLFVEKER 17 1 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 27829000.0 7286600.0 5816400.0 14726000.0 True False 9432647.340359332 5492712.226973482 12046019.10151979 1.0 0.5823086593592759 1.2770560232840107 23.16923129980038 -6.743894760551344 1.6722094681257726 0.752599117083653 1.2778353267667226 0.6223300854858629 0.1754904076123787 0.31084610319614303 1.7080790872085039 0.08296926042125742 0.20275312921590183 1.8034547060823247e-07 6.743894760551344 0.5252362096830696 HSQFLGYPITLYLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSQFLGYPITLYLEK 15 0 Q58FF8 Q58FF8 HSP90AB2P Putative heat shock protein HSP 90-beta 2 0 880376460.0 234490500.0 411891760.0 233994200.0 False True 307419316.3092323 350439114.9495056 209782724.81486017 1.0 1.1399385020978963 0.6823992953124659 28.19563257691876 -6.82462230907205 1.351794780635506 1.0750936504870623 0.6713881470312061 0.8946796422948268 0.06212365759844811 0.18754174046843727 0.6721007479478354 0.0361018288104924 0.08312276426210657 1.497537446604191e-07 6.82462230907205 -0.4037055034558562 HSQFLGYPITLYLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HSQFLGYPITLYLEK 15 0 Q58FF8 Q58FF8 HSP90AB2P Putative heat shock protein HSP 90-beta 2 0 728610000.0 133530000.0 124690000.0 470390000.0 False True 129291163.24062651 174479367.24975982 347180747.6024841 1.0 1.349507289411826 2.6852627735767114 26.946048432664778 -6.945922301414006 0.6019493364786139 0.9850167839814028 3.118360416351734 0.998841184730623 0.02472139520733036 0.08516564261427079 0.04306573109971085 0.02532408388085053 0.11232534473898188 1.1326029763973916e-07 6.945922301414006 2.133343632370331 up HSQFLGYPITLYLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSQFLGYPITLYLEK 15 0 Q58FF8 Q58FF8 HSP90AB2P Putative heat shock protein HSP 90-beta 2 0 600545470.0 234490500.0 159045870.0 207009100.0 False True 321187974.7174913 152018697.5690408 158117814.0662412 1.0 0.47330133608754354 0.4922905790769955 28.258842638441653 -10.31337269296431 8.823417439029885 1.000000452129192 0.4827959576004992 0.9989900168346514 0.007752325987646668 6.894839958277469e-08 5.368526776791369e-09 0.007506163903749513 0.0025020524537105408 4.85989970866846e-11 10.31337269296431 -0.5172044945286929 HSQFLGYPITLYLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HSQFLGYPITLYLEK 15 0 Q58FF8 Q58FF8 HSP90AB2P Putative heat shock protein HSP 90-beta 2 0 384230000.0 133530000.0 115720000.0 134980000.0 False True 111036111.38199823 115096593.39137842 163203693.9229948 1.0 1.0365690220851744 1.4698253738508917 26.726453708099054 -6.923576410742485 0.7977320805906325 0.9916164250294248 1.5457872662879495 0.9951186923209003 0.014908173250248968 0.0961121546578562 0.09503572835235777 0.013094668615097503 0.04067396119931812 1.1924044530925014e-07 6.923576410742485 0.5541708412585247 HSQYHVDGSLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSQYHVDGSLEK 12 0 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 0 1701400.0 0.0 1701400.0 0.0 False True 0.0 1447557.7520052553 0.0 0.0 HSQYHVDGSLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HSQYHVDGSLEK 12 0 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 0 838990.0 838990.0 0.0 0.0 False True 812356.7216899063 0.0 0.0 1.0 0.0 0.0 19.631753856529645 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 HSQYHVDGSLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSQYHVDGSLEK 12 0 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 0 3813200.0 0.0 1687800.0 2125400.0 False True 0.0 1613227.4151917736 1623424.2939870225 0.0 HSQYHVDGSLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HSQYHVDGSLEK 12 0 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 0 1952890.0 838990.0 1113900.0 0.0 False True 697657.3585589954 1107899.1996081613 0.0 1.0 1.588027684387242 0.0 19.41215913196392 -6.823003996490051 1.469901839033257 1.3207445552886938 1.5292631095264908e-20 0.8497562712290404 0.2540962022116267 0.202366141788168 0.8760168899794636 0.13809022983256808 0.30199666924021756 1.503128133852858e-07 6.823003996490051 -1.3207445552886938 HSQYHVDGSLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSQYHVDGSLEK 12 0 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 0 5562100.0 2132300.0 1629300.0 1800500.0 False True 2760304.3839168106 1538628.0227301924 1472827.4746901004 1.0 0.5574124475891725 0.5335742982808986 21.396395933774865 -13.999999999999998 0.416306788185042 9.28894966349653 0.5326904268430275 0.999859552697661 0.002541774887237192 29.33511394436183 0.21470364650822782 220.9262984665124 0.0058394977052825415 1.0000000000000041e-14 13.999999999999998 -8.756259236653502 HSQYHVDGSLEK(ub)DR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HSQYHVDGSLEKDR 14 1 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 56678500.0 8213500.0 25046000.0 23419000.0 True False 12460479.987282068 20576345.61470884 18790224.385087658 1.0 1.651328491014016 1.5079855996130258 23.570856307367514 -10.07070647946453 4.600122335377576 0.9999707339806545 1.5796570453319463 0.9561473176402355 0.05851949044172155 30703171.35901297 1.1209262264291509 10010.956757577753 0.021415940609216356 8.497545927520847e-11 10.07070647946453 0.5796863113512918 HSQYHVDGSLEK(ub)DR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSQYHVDGSLEKDR 14 1 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 9619900.0 3120400.0 3321900.0 3177600.0 True False 4274096.205639284 3175127.473945698 2427116.3247262463 1.0 0.7428769314449225 0.5678665635845739 22.027187951312683 -7.996363079184748 0.10415223703638463 1.4864797056590742 1.853147685793781e-11 0.9999885632365819 0.0006001662804135377 0.10862726250572508 0.0170619633420883 0.10775676906879086 0.12338298948958945 1.0084094823544581e-08 7.996363079184748 -1.4864797056405428 HSQYHVDGSLEK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSQYHVDGSLEKDR 14 1 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 41527500.0 8213500.0 18220000.0 15094000.0 True False 10632537.662289878 17206040.983332813 12347046.877518658 1.0 1.6182440664524513 1.1612511772527814 23.341982629459963 -10.38683347377833 5.249486489454256 0.9997645091275715 1.38974762185263 0.4923369055374287 0.18656656576995387 0.0005144996758225549 6.009617088438848e-05 0.18074996732187115 0.06021410018217173 4.103614221335807e-11 10.38683347377833 0.38998311272505837 HSSGCAFLSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HSSGCAFLSVK 11 0 K7EMW2;A0A0B4J1S3;H3BLT4;O15392-5;O15392-4;O15392;O15392-2 K7EMW2 BIRC5 Baculoviral IAP repeat-containing protein 5 0 33302600.0 7840400.0 17304000.0 8158200.0 False True 11894460.010018438 14215966.003230909 6545728.1941339215 1.0 1.1951754002499582 0.5503173905011746 23.503786441350634 -6.82553907028197 1.3478734856689152 1.1046501740968508 0.5345113715706838 0.89662127247054 0.0868152091167024 0.18638445715490323 0.6638154635650676 0.05059492856456786 0.1164694568297554 1.4943795979720526e-07 6.82553907028197 -0.570138802526167 HSSGCAFLSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSSGCAFLSVK 11 0 K7EMW2;A0A0B4J1S3;H3BLT4;O15392-5;O15392-4;O15392;O15392-2 K7EMW2 BIRC5 Baculoviral IAP repeat-containing protein 5 0 30249400.0 7840400.0 13177000.0 9232000.0 False True 10149552.35738938 12443688.366486065 7551870.728319352 1.0 1.2260332208076585 0.7440594877882682 23.274912763443083 -6.779176011173712 1.5390667501980544 1.1281221929131489 0.7403385804464 0.7644710389708917 0.09555390196797843 0.25185524181786234 1.178297017204051 0.04890268038035828 0.11547021451640375 1.6627386379102184e-07 6.779176011173712 -0.38778361246674886 HSSVYPTQEELEAVQNMVSHTER ddPTM_RPMI8226_Bortezomib_2h_R1 1 HSSVYPTQEELEAVQNMVSHTER 23 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7ER69;K7EJ09;K7EM82;K7ENK6;K7ERM6 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 21229800.0 8553500.0 4337500.0 8338800.0 False True 8281973.824449195 6069486.369763677 6154618.121362271 1.0 0.7328550534470372 0.7431342155650429 22.9815432123366 -9.970085750734656 5.200864076336086 1.0000010965035095 0.737994634506013 0.9988469289027639 0.004196450368272555 5767037.378477819 1.7700150351149957 79.6344330040536 0.001436556579149208 1.0713077563901828e-10 9.970085750734656 -0.26200646199749655 HSTLDFMLGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSTLDFMLGAK 11 0 P52788;P52788-2 P52788 SMS Spermine synthase 0 20936200.0 6058100.0 5919400.0 8958700.0 False True 7942227.766723847 5036248.593640479 8031739.6619184865 1.0 0.6341103203739927 1.0112703762500586 22.921112304300276 -10.97480284641239 11.005447224408327 1.0936324625394047 0.8226903484122351 0.22760895161934036 0.15397494804265893 0.08206990683798267 0.00018790026407633712 0.034588668150544684 0.0496952007918642 1.0597346962460249e-11 10.97480284641239 -0.2709421141271696 HSTLDFMLGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HSTLDFMLGAK 11 0 P52788;P52788-2 P52788 SMS Spermine synthase 0 13426600.0 3803500.0 2508200.0 7114900.0 False True 3682759.9744306426 3509737.3400902105 5251294.247575237 1.0 0.9530182158104992 1.425912707869888 21.8123559413153 -6.882465824420942 1.0659843285264474 0.9698149324712404 1.461047885225821 0.9756192609090548 0.03321439805196833 0.1254667815818646 0.2592949056094241 0.02394688157992989 0.058288449387091205 1.310793187479655e-07 6.882465824420942 0.4912329527545807 HSTLDFMLGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HSTLDFMLGAK 11 0 P52788;P52788-2 P52788 SMS Spermine synthase 0 35107000.0 5375800.0 20145000.0 9586200.0 False True 8155481.62362342 16549967.356396599 7691483.368219277 1.0 2.029305946623367 0.9431059651878669 22.959338647425753 -6.658368584363458 1.979145278457736 1.6634505925944207 0.9476866416636772 0.22856339120344082 0.4384285014632354 0.48828116526434157 3.675118878429228 0.17910139020906476 0.48579574265402464 2.1959953473306584e-07 6.658368584363458 -0.7157639509307435 HSTLDFMLGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSTLDFMLGAK 11 0 P52788;P52788-2 P52788 SMS Spermine synthase 0 17647300.0 6058100.0 6448800.0 5140400.0 False True 8297943.283996717 6163870.692670174 3926343.3898611516 1.0 0.7428190916365647 0.4731706707894034 22.984322365823168 -6.970528150997242 0.24524754075703667 1.0907357235909758 0.11740372931698055 0.9999862122299962 0.0007986757919769514 0.07613173554882317 0.008414833822964946 0.006213141965398286 0.02604887668609251 1.0702170091251918e-07 6.970528150997242 -0.9733319942739953 down HSTLDFMLGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HSTLDFMLGAK 11 0 P52788;P52788-2 P52788 SMS Spermine synthase 0 10501400.0 3803500.0 2882300.0 3815600.0 False True 3162778.773619643 2866772.477808244 4613424.3186589 1.0 0.9064094212720941 1.4586617177081487 21.592761216749576 -6.863278913367254 1.1689743572254476 0.948703433460095 1.4871393553411139 0.9575075302040286 0.04974471342290751 0.14346687281326828 0.3706710785912881 0.03314169660925401 0.07767545516775112 1.3700016387106905e-07 6.863278913367254 0.5384359218810189 HSTLDFMLGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSTLDFMLGAK 11 0 P52788;P52788-2 P52788 SMS Spermine synthase 0 24907700.0 5375800.0 12669000.0 6862900.0 False True 6959079.072860285 11963959.013053961 5613922.61930058 1.0 1.7191871061951587 0.8067048183421739 22.730464969518202 -6.696568280344447 1.8429916697311068 1.4480826417388886 0.8095809068924055 0.40131607909122335 0.30377340613953174 0.4027302786225744 2.656937034581547 0.13161288926603806 0.3399294322556012 2.0110909869980225e-07 6.696568280344447 -0.6385017348464831 HSVGVVIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSVGVVIGR 9 0 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 409930000.0 132510000.0 120120000.0 157300000.0 False True 173721893.2286653 102198564.22409262 141024104.92814577 1.0 0.5882883402011484 0.8117808429736583 27.37220433964163 -10.594671652612773 8.002414055209382 1.0001711850804507 0.7000345915874033 0.7060467383445207 0.09124043218836733 0.0002788172646274764 1.4122286277733293e-05 0.0883927042762195 0.029447722863859487 2.5428945287746096e-11 10.594671652612773 -0.30013659349304733 HSVGVVIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HSVGVVIGR 9 0 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 355562000.0 102290000.0 55592000.0 197680000.0 False True 99042859.94071504 77790175.50845015 145901677.72711802 1.0 0.7854193180105431 1.4731165660447574 26.56154963832263 -6.822860256031804 1.3593999527134768 0.8846644326017437 1.4890777360077634 0.8908481305838589 0.09491474592609102 0.1897893569610854 0.6883520776460158 0.05485524563067802 0.12634980688797115 1.503625713479028e-07 6.822860256031804 0.6044133034060197 HSVGVVIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HSVGVVIGR 9 0 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 292649000.0 100480000.0 86619000.0 105550000.0 False True 152435506.071967 71161162.69266407 84687996.2357915 1.0 0.4668280017325351 0.555566077865147 27.18362374111487 -10.802083806383548 7.229337573819866 1.0181272052570272 0.511197039798841 0.9758782248453588 0.03622716788019094 0.010060927265374445 0.0002754357109490544 0.03334205972078888 0.011692268156686635 1.5773068653268737e-11 10.802083806383548 -0.5069301654581861 HSVGVVIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSVGVVIGR 9 0 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 308472000.0 132510000.0 81090000.0 94872000.0 False True 181502527.9481034 77507175.67122926 72465187.55017252 1.0 0.4270308328344094 0.3992516708686963 27.435414401164522 -13.707278792249195 0.434107511189351 9.999999999999956 0.39880385718971073 0.9998769774002576 0.0030710268487424922 24.848204078829433 0.2214459158487825 211.2414120147029 0.006510998790413802 1.9621003161459357e-14 13.707278792249195 -9.601196142810245 HSVGVVIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HSVGVVIGR 9 0 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 249527000.0 102290000.0 82221000.0 65016000.0 False True 85058667.21534182 81778059.15340927 78610544.9999809 1.0 0.9614312312979572 0.9241920614740377 26.341954913756908 -6.971554804342871 0.21790906399278476 1.0176329961210118 0.8669413570406871 0.9999920618956567 8.700931274798721e-05 0.07580156616943194 0.0071986113727941356 0.0010482032249064137 0.0037912792123891742 1.0676900504546574e-07 6.971554804342871 -0.15069163908032468 HSVGVVIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSVGVVIGR 9 0 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 368340000.0 100480000.0 161850000.0 106010000.0 False True 130073340.7569107 152842905.2224156 86717267.75445572 1.0 1.1750517387575836 0.6666797919530524 26.95475006320732 -6.813767335101748 1.398905905612408 1.094984668005404 0.6570218072871759 0.8693703700060169 0.07621340354560399 0.20171161502557314 0.7772859898037404 0.0428323080460513 0.09890925236420042 1.5354393445327585e-07 6.813767335101748 -0.4379628607182282 HSVHTLVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HSVHTLVFR 9 0 O43660-2;O43660;D6RA26;B7Z982 O43660-2 PLRG1 Pleiotropic regulator 1 0 20364400.0 7202300.0 4491600.0 8670500.0 False True 9442285.04717241 3821470.788119674 7773359.833308885 1.0 0.4047188544963545 0.823249858956196 23.17070460553178 -10.238556992198804 5.732350408116923 1.0000166627534481 0.6139843567263059 0.5314424344406914 0.17086456707687692 3.638752896201743e-05 4.8333865995226654e-06 0.16544603952526665 0.05514630189547032 5.773551017860982e-11 10.238556992198804 -0.3860323060271422 HSVHTLVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HSVHTLVFR 9 0 O43660-2;O43660;D6RA26;B7Z982 O43660-2 PLRG1 Pleiotropic regulator 1 0 14070300.0 3453700.0 2452600.0 8164000.0 False True 3344064.1839597966 3431935.970140039 6025603.485249865 1.0 1.02627694366685 1.8018803329650166 21.673171107230967 -6.914097659722845 0.8673689757785646 0.9789845026738383 1.9114205364241739 0.9923780656942798 0.03247445787589768 0.10177040387868716 0.1245322731253253 0.027138105768226898 0.07722071696352657 1.2187155157683956e-07 6.914097659722845 0.9324360337503356 HSVHTLVFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HSVHTLVFR 9 0 O43660-2;O43660;D6RA26;B7Z982 O43660-2 PLRG1 Pleiotropic regulator 1 0 16622300.0 4729000.0 7351900.0 4541400.0 False True 7174238.736209529 6039896.004343119 3643790.2994336733 1.0 0.8418866762627788 0.5078992257454273 22.77439432379369 -6.958962152812608 0.4498226131024428 1.0107899452467393 0.32575960859714087 0.9997297460947837 0.003372235031900781 0.08007396779386375 0.022517107420386734 0.004462903426163872 0.02762699187796043 1.099101617974802e-07 6.958962152812608 -0.6850303366495984 HSVHTLVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HSVHTLVFR 9 0 O43660-2;O43660;D6RA26;B7Z982 O43660-2 PLRG1 Pleiotropic regulator 1 0 18675800.0 7202300.0 4276400.0 7197100.0 False True 9865184.944839071 4087454.507836297 5497293.208927262 1.0 0.4143312599501372 0.5572417790102503 23.23391466705467 -10.19940057135067 8.133965495115298 1.000000158159519 0.4857865194805053 0.9452422171241156 0.05834297509559448 1.6729142574344343e-07 1.645467768238261e-08 0.056490359563294276 0.01883011424278596 6.318288154677628e-11 10.19940057135067 -0.5142136386790137 HSVHTLVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HSVHTLVFR 9 0 O43660-2;O43660;D6RA26;B7Z982 O43660-2 PLRG1 Pleiotropic regulator 1 0 11123800.0 3453700.0 5140900.0 2529200.0 False True 2871904.5748521467 5113204.951311245 3058044.026300477 1.0 1.7804229973673433 1.0648139402256822 21.453576382665243 -10.23859096950847 4.481282742503312 0.9998363713588351 1.422618468801237 0.3174216439306331 0.2921461742345829 0.000477782543912639 8.117967649411962e-05 0.2829780099283052 0.09428977228681142 5.773099338032089e-11 10.23859096950847 0.422782097442402 HSVHTLVFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HSVHTLVFR 9 0 O43660-2;O43660;D6RA26;B7Z982 O43660-2 PLRG1 Pleiotropic regulator 1 0 22435100.0 4729000.0 9374300.0 8331800.0 False True 6121783.7225261945 8852611.964328019 6815497.8914873535 1.0 1.4460837503542072 1.113318960682736 22.54552064588614 -10.220120295957388 5.619646540311304 0.9999884110463544 1.2797013555184822 0.48506823063033233 0.1358506565099832 1.972581073145005e-05 2.7374957772626385e-06 0.1315422787251707 0.043845610852870205 6.023927051967521e-11 10.220120295957388 0.2797129444721278 HTAAPTDPADGPV ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTAAPTDPADGPV 13 0 Q04941 Q04941 PLP2 Proteolipid protein 2 0 597680.0 597680.0 0.0 0.0 False True 783564.2679413524 0.0 0.0 1.0 0.0 0.0 19.57969208383507 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 HTAMVSWGGVSIPNSPFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTAMVSWGGVSIPNSPFR 18 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 18420100.0 5363700.0 9325900.0 3730500.0 False True 7031862.642144686 7934512.072073478 3344503.645482818 1.0 1.128365623144978 0.4756212991758269 22.745475458998875 -6.855654048766504 1.2075519808588289 1.0689892455764753 0.44654623191199455 0.948126070388049 0.06430905253275478 0.15134987998848992 0.42187212066355845 0.04160448299420432 0.09668698028969477 1.3942670089174956e-07 6.855654048766504 -0.6224430136644807 down HTAMVSWGGVSIPNSPFR ddPTM_RPMI8226_Bortezomib_2h_R1 2 HTAMVSWGGVSIPNSPFR 18 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 47075500.0 16675400.0 10613300.0 19786800.0 False True 16146048.554652464 14851246.037628321 14604043.488723911 1.0 0.9198068485523632 0.9044964431570333 23.94467779952552 -13.999989068271924 0.23283851202527764 1.5129737153415252 0.8972506278748145 0.9995137799304794 0.0009234780887712833 13.3810360885476 0.1527620038451861 3.1784287948720884 0.007809368427714167 1.0000251715509058e-14 13.999989068271924 -0.6157230874667108 HTAMVSWGGVSIPNSPFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HTAMVSWGGVSIPNSPFR 18 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 69017000.0 17413000.0 23690000.0 27914000.0 False True 26416794.06081968 19462334.409185164 22396785.664859146 1.0 0.7367409672943966 0.8478237598890606 24.65495205611036 -10.21564601382494 4.891216182626773 1.0000302710877123 0.7922823635913719 0.8233905349527252 0.04534936017795724 1.4972056169623914e-05 2.4009418382012784e-06 0.04391572313665821 0.014636443060689943 6.086308840216283e-11 10.21564601382494 -0.2077479074963403 HTAMVSWGGVSIPNSPFR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 HTAMVSWGGVSIPNSPFR 18 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 41765000.0 7260200.0 13023800.0 21481000.0 False True 9944492.139527747 12448365.452052731 16407630.215081986 1.0 1.2517849355597046 1.6499213820949499 23.24546626451658 -6.964366015453255 0.368777090898258 0.968955378627003 1.9465827496645065 0.9998994659187095 0.0026827519148632864 0.07817682813417819 0.015622964473723975 0.005257695746063312 0.033835818046327217 1.0855103896797041e-07 6.964366015453255 0.9776273710375035 HTAMVSWGGVSIPNSPFR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 HTAMVSWGGVSIPNSPFR 18 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 100322600.0 25449700.0 47158600.0 27714300.0 False True 32945138.338586297 44534182.454258904 22670581.7727319 1.0 1.3517679603153823 0.6881313272914523 24.973562248950138 -6.7627040635741436 1.6024214939317583 1.203636999062048 0.6853866313397886 0.701882311145133 0.14801648283236823 0.2783858639364856 1.4094516399229358 0.07286267930936326 0.17462710060788492 1.7270143111516809e-07 6.7627040635741436 -0.5182503677222593 HTATHLLNWALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTATHLLNWALR 12 0 Q5JTZ9 Q5JTZ9 AARS2 Alanine--tRNA ligase, mitochondrial 0 18755100.0 6510400.0 5373100.0 6871600.0 False True 8535197.446803289 4571454.424179761 6160592.7490416095 1.0 0.535600313018174 0.7217867878790494 23.02499309717931 -10.160886518014719 5.318194032975378 1.0000127986505103 0.6286935504484724 0.8413410370679985 0.07601031006993367 1.1535015238418655e-05 1.8200500415059318e-06 0.07359920162643531 0.024532222086672426 6.904201883979036e-11 10.160886518014719 -0.3713192482020379 HTATHLLNWALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HTATHLLNWALR 12 0 Q5JTZ9 Q5JTZ9 AARS2 Alanine--tRNA ligase, mitochondrial 0 23590600.0 6252800.0 4027800.0 13310000.0 False True 6054308.286609683 5636121.544699513 9823711.708558984 1.0 0.9309274119993074 1.6225985271159866 22.529530708685016 -6.882329369942871 1.066754285235409 0.955718891200647 1.6738538607249265 0.9755150059039283 0.04867323013924645 0.12558529976509225 0.26000414607584926 0.03507171914125087 0.0853349977555854 1.311205100847083e-07 6.882329369942871 0.7181349695242795 HTATHLLNWALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HTATHLLNWALR 12 0 Q5JTZ9 Q5JTZ9 AARS2 Alanine--tRNA ligase, mitochondrial 0 12840400.0 6252800.0 2670600.0 3917000.0 False True 5199480.246007338 2656212.9477274045 4736026.589838271 1.0 0.5108612442113037 0.9108653876462073 22.309935984119292 -9.988930305911822 7.008390040875297 1.000000023720969 0.7108633159287557 0.4106040872184308 0.1633010077357626 6.050107135175278e-08 8.74077141773417e-09 0.1581155326253749 0.0527051736149579 1.0258165325603912e-10 9.988930305911822 -0.28913670779221323 HTDNTVQWLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTDNTVQWLR 10 0 Q13576;F5H7S7;E7EWC2;D6R939 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 0 6491200.0 1426300.0 1900200.0 3164700.0 False True 1869893.1123088468 1616697.5669215852 2837247.201945979 1.0 0.8645935729050155 1.5173312224476263 20.83452437379576 -6.852585897827957 1.2224740281483082 0.927547087751945 1.5447670566064524 0.9439937093123236 0.0665651920727175 0.15463517885187594 0.4433914002427415 0.042576895390641877 0.09870673997536386 1.4041519330310565e-07 6.852585897827957 0.6172199688545074 HTDNTVQWLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HTDNTVQWLR 10 0 Q13576;F5H7S7;E7EWC2;D6R939 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 0 7489500.0 1426300.0 2304600.0 3758600.0 False True 1953641.654308202 2202775.151706934 2870896.090796852 1.0 1.127522617491974 1.4695100733882827 20.89773443531865 -6.953940766474264 0.5137644702204474 0.9938958035652204 1.6182369759134865 0.9994753440261209 0.0045405339263025635 0.08194089833398054 0.029704417793684865 0.005196454782334002 0.028232747480929094 1.1118833669721665e-07 6.953940766474264 0.624341172348266 HTGCCGDNDPIDVCEIGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTGCCGDNDPIDVCEIGSK 19 0 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 54945800.0 5493000.0 32011800.0 17441000.0 False True 7201376.194287667 27235764.22101907 15636372.625885487 1.0 3.782022142187661 2.1713034014649444 22.779841203511452 -9.746322808521235 6.530906009498351 0.9999999882898519 2.9766627718271867 0.6675535851894714 0.6575731723213307 1.2167996270728568e-07 2.4695926788041918e-08 0.6366924910706225 0.2122308287756394 1.7934001075964536e-10 9.746322808521235 1.9766627835373347 HTGCCGDNDPIDVCEIGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HTGCCGDNDPIDVCEIGSK 19 0 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 88382800.0 9077700.0 74085400.0 5219700.0 False True 13771534.56876489 60864281.53812787 4188024.0071242196 1.0 4.4195714888719575 0.30410728638935014 23.715185992848802 -6.686139611860035 1.8802115334893925 3.151558046502105 0.31898047609121144 0.3524103829887931 1.4473896104855588 0.4250050405882241 2.9099355234652076 0.6165461551960982 1.613338923362568 2.0599675927694037e-07 6.686139611860035 -2.8325775704108933 HTGCCGDNDPIDVCEIGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HTGCCGDNDPIDVCEIGSK 19 0 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 57077000.0 5493000.0 20341000.0 31243000.0 False True 7523910.542743432 19442267.361308146 23864046.869782887 1.0 2.5840641313923625 3.1717611120189337 22.843051265034344 -9.619484373350504 0.27852303305525894 5.062799028439193e-16 3.445058065368411 0.9988885098938505 0.030578325801745576 1.0082262831898534 0.11521335398723388 1.1097364209863247 0.22647974176372865 2.4016826829332214e-10 9.619484373350504 3.4450580653684106 HTGCCGDNDPIDVCEIGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HTGCCGDNDPIDVCEIGSK 19 0 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 0 19250400.0 9077700.0 4807900.0 5364800.0 False True 11751261.598218644 4540336.138516227 4388461.447496498 1.0 0.38637010167525243 0.3734459837198874 23.48631231494125 HTGCCGDNDPIDVCEIGSK(ub)VCAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTGCCGDNDPIDVCEIGSKVCAR 23 1 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 1 9430100.0 2606800.0 3646300.0 3177000.0 True False 3417540.044287108 3102286.2531660744 2848274.5159359076 1.0 0.907754177848472 0.8334282785353733 21.704526811721994 -6.973577049698623 0.14984975844111648 1.0865832448417276 0.6526446371418722 0.9999985440220174 8.200977232213262e-05 0.07515812866489403 0.0045796437905856234 0.003798941359862953 0.00927773764354091 1.0627300239099171e-07 6.973577049698623 -0.4339386076998555 HTGCCGDNDPIDVCEIGSK(ub)VCAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HTGCCGDNDPIDVCEIGSKVCAR 23 1 Q15181;Q5SQT6 Q15181 PPA1 Inorganic pyrophosphatase 1 19776900.0 5448700.0 3184200.0 11144000.0 True False 7053449.559934113 3006996.470863246 9115906.347096069 1.0 0.4263157261298023 1.2924039889471077 22.749897563838214 -6.7281197548184375 1.73037463198076 0.6540393981111423 1.2916893399863671 0.5504546860718396 0.24119968553176593 0.33974604457566077 1.9920976575235165 0.11050928957017381 0.27477674433268884 1.8701663789975733e-07 6.7281197548184375 0.6376499418752248 HTGPGILSMANAGPNTNGSQFFICTAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 HTGPGILSMANAGPNTNGSQFFICTAK 27 0 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 2682333690.0 742070890.0 1288810500.0 651452300.0 False True 972862123.0147214 1096524997.1439824 584046265.1677171 1.0 1.1271124357746116 0.600338168534987 29.857660115454074 -6.8429744306274465 1.2685097083285939 1.0676166544885703 0.5819665893493938 0.9294486304487778 0.05961586129692172 0.16535291621598444 0.5155570941839939 0.03683228945426039 0.08493440025680565 1.435573951223837e-07 6.8429744306274465 -0.4856500651391765 HTGPGILSMANAGPNTNGSQFFICTAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 HTGPGILSMANAGPNTNGSQFFICTAK 27 0 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 2132801800.0 1122913600.0 553483200.0 456405000.0 False True 1087267322.419828 774491928.136758 336858838.6434914 1.0 0.7123288929653884 0.30982154222549113 30.018059548090704 -7.050339384485701 0.34848681443407553 1.0419492584966055 1.692398813572119e-16 0.9999260492124978 0.0024341684495395787 0.07308820958370607 0.014388061463772108 0.00586007382219472 0.03302916554830533 8.90554731763044e-08 7.050339384485701 -1.0419492584966052 down HTGPGILSMANAGPNTNGSQFFICTAK ddPTM_RPMI8226_Bortezomib_8h_R1 2 HTGPGILSMANAGPNTNGSQFFICTAK 27 0 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 6323959100.0 1564198200.0 3171316000.0 1588444900.0 False True 2373003027.606093 2605369882.195001 1274488069.274868 1.0 1.0979210105868773 0.5370781471613136 31.144066795187953 -6.861842791916368 1.1762939413978188 1.0534156489643123 0.50893542473554 0.9558470580643897 0.05139526902186622 0.1449208861668067 0.37997429695204316 0.034050023390461044 0.07966023843299509 1.3745394476162946e-07 6.861842791916368 -0.5444802242287723 HTGPGILSMANAGPNTNGSQFFICTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 HTGPGILSMANAGPNTNGSQFFICTAK 27 0 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 3940735390.0 742070890.0 1457334900.0 1741329600.0 False True 1016434551.744767 1392945025.355942 1330063412.288843 1.0 1.3704227418921107 1.3085578505824251 29.920870176976965 -10.109557033307333 4.546472939128272 0.9999699863113589 1.3394902962128081 0.9756997217458507 0.025256236153294337 7.77563425122667e-06 1.522868644597883e-06 0.024456430599691308 0.008151415162337996 7.77039268154503e-11 10.109557033307333 0.3395203099014492 HTGPGILSMANAGPNTNGSQFFICTAK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 HTGPGILSMANAGPNTNGSQFFICTAK 27 0 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 2300225800.0 1122913600.0 290323300.0 886988900.0 False True 933752411.9071417 288759270.7582367 1072454178.0166961 1.0 0.3092460775211928 1.1485423377126953 29.79846482352498 -6.688072122265441 1.8735998197433945 0.5661589463641137 1.1455530518834072 0.36132944347144946 0.29225544810478077 0.4207898134803071 2.8624539121101717 0.12486728700932598 0.32591542836770093 2.0508215754184218e-07 6.688072122265441 0.5793941055192935 HTGPGILSMANAGPNTNGSQFFICTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 HTGPGILSMANAGPNTNGSQFFICTAK 27 0 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 4932513800.0 1564198200.0 2031915500.0 1336400100.0 False True 2024885404.8561568 1918837616.2277262 1093188994.422992 1.0 0.9476277579096067 0.5398769687416703 30.915193117280403 -6.930605782784027 0.7418095790989345 1.006063596592901 0.4548636670721426 0.9966558048523764 0.011893933318710697 0.09232480815145912 0.07615014534288064 0.01087518101736126 0.036772387806912527 1.1732598722470117e-07 6.930605782784027 -0.5511999295207584 HTGPGILSMANAGPNTNGSQFFICTAK(ub)TEWLDGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HTGPGILSMANAGPNTNGSQFFICTAKTEWLDGK 34 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 1 56149000.0 17847000.0 14383000.0 23919000.0 True False 27075203.790469736 11816241.275108084 19191399.165929858 1.0 0.43642298564221005 0.7088182720414125 24.690468861007044 -10.460828736830374 6.203293656301643 1.0001932750878009 0.5726206288418193 0.7664758478552782 0.11120491000288883 0.00029738361860154143 2.584751102073359e-05 0.10772155877428789 0.035891230371473556 3.460758252373933e-11 10.460828736830374 -0.42757264624598157 HTGPGILSMANAGPNTNGSQFFICTAK(ub)TEWLDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HTGPGILSMANAGPNTNGSQFFICTAKTEWLDGK 34 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 1 17352700.0 5226400.0 2927400.0 9198900.0 True False 4345983.168777618 2911629.515156595 11122347.459091976 1.0 0.6699587646989302 2.559224697186374 22.05125115655205 -6.861828596737467 1.1765594509255244 0.8200098742668435 2.6539167553716534 0.9558191408835259 0.17317944152129536 0.14492418455785777 0.380192499880507 0.11472006289126044 0.26834845687605213 1.374584376007193e-07 6.861828596737467 1.8339068811048098 up HTGPGILSMANAGPNTNGSQFFICTAK(ub)TEWLDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HTGPGILSMANAGPNTNGSQFFICTAKTEWLDGK 34 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 1 54173000.0 17847000.0 12955000.0 23371000.0 True False 23103293.316964455 12234042.861639746 19117717.80671054 1.0 0.529536750185154 0.8274888581651969 24.461595183099494 -10.408966884496923 6.401844463695517 1.000052900722339 0.6785128041751763 0.6081951648590024 0.12163843872295688 9.185668821097219e-05 8.480272163544551e-06 0.11779522064487306 0.03925863728605695 3.8997172137944946e-11 10.408966884496923 -0.32154009654716276 HTGPNSPDTANDGFVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTGPNSPDTANDGFVR 16 0 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;E5RGH4;H0YAQ2 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 77796140.0 12770060.0 38311180.0 26714900.0 False True 16741672.325436959 32595301.279809996 23950698.415415894 1.0 1.9469561132363913 1.4306037025360774 23.996940310087282 -10.253736891054759 4.927519584568937 0.9998551713823646 1.6887799078868724 0.7034845604737626 0.2107999889475044 0.0003354632896299333 5.080547139705926e-05 0.20414856562591457 0.06803540388088432 5.575234114566581e-11 10.253736891054759 0.6889247365045078 HTGPNSPDTANDGFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HTGPNSPDTANDGFVR 16 0 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;E5RGH4;H0YAQ2 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 75368520.0 20045910.0 10239410.0 45083200.0 False True 19409563.55962639 14328059.81081775 33274557.45299075 1.0 0.7381958778620548 1.7143382616909932 24.210264342415524 -6.835333440594237 1.3039815843305607 0.8605408691690484 1.743571520216876 0.9161112010437573 0.11948516144828365 0.17432293815383448 0.5778028034225418 0.07190289052409664 0.16549211004460554 1.4610549817280682e-07 6.835333440594237 0.8830306510478276 HTGPNSPDTANDGFVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HTGPNSPDTANDGFVR 16 0 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;E5RGH4;H0YAQ2 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 248896900.0 36846700.0 182992000.0 29058200.0 False True 55899137.75459751 150335647.87697828 23314834.033338472 1.0 2.689409066325244 0.4170875432049202 25.736322693849587 -6.7076009503111775 1.8034660241844518 2.041138712873323 0.42273148248531073 0.45379504002500404 0.7121811446753493 0.379938780676677 2.407290921827641 0.314413113931854 0.8011763769461413 1.9606453769919022e-07 6.7076009503111775 -1.6184072303880124 HTGPNSPDTANDGFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HTGPNSPDTANDGFVR 16 0 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;E5RGH4;H0YAQ2 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 85069360.0 12770060.0 39296300.0 33003000.0 False True 17491496.279895548 37560059.53051337 25208371.118120696 1.0 2.1473325626055395 1.4411786570308913 24.060150371610174 -10.251816899905778 5.6279153178131756 0.9999715410314572 1.7942556094569 0.6278084168647174 0.28828612499667366 0.00017686298159325507 2.351250553359244e-05 0.2791489138279322 0.09304394671820063 5.599936470409533e-11 10.251816899905778 0.7942840684254427 HTGPNSPDTANDGFVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HTGPNSPDTANDGFVR 16 0 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;E5RGH4;H0YAQ2 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 40080190.0 20045910.0 12905000.0 7129280.0 False True 16669062.349386025 12835478.203558065 8619979.48593368 1.0 0.7700180090832066 0.5171244371913446 23.9906696178498 -6.96990455106582 0.26046016031269886 1.0706023772176014 0.2090326342837861 0.9999816264510595 0.0008452961549111801 0.07633373710391547 0.009141117464592093 0.005263566266928736 0.023844473577073692 1.071754828873592e-07 6.96990455106582 -0.8615697429338154 HTGPNSPDTANDGFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HTGPNSPDTANDGFVR 16 0 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;E5RGH4;H0YAQ2 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 98130700.0 36846700.0 30694900.0 30589100.0 False True 47698779.5070429 28986701.832014345 25022197.67067086 1.0 0.6077032186480652 0.5245877971987992 25.507449015942036 -13.999999999996813 0.21810193623611213 3.3477805489326276 0.4793124549961807 0.9994960632186766 0.004653951521190104 12.948673104773492 0.14796196298739625 13.080354312283333 0.046580823224068216 1.0000000000073378e-14 13.999999999996813 -2.868468093936447 HTGYVGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTGYVGLK 8 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 16917200.0 5162200.0 6225600.0 5529400.0 False True 6767694.19081591 5296764.7471987335 4957270.729750084 1.0 0.7826542686261889 0.7324903563871638 22.690232948751138 -13.999999999865611 0.20599426439449173 2.2367545468989585 0.7017704555351472 0.9994881552453339 0.0026266828980359143 12.655865163796188 0.14388248439076132 6.32304046930138 0.03057096476731908 1.000000000309441e-14 13.999999999865611 -1.5349840913638113 HTGYVGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HTGYVGLK 8 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 9502300.0 2857500.0 2520200.0 4124600.0 False True 2766790.2266164175 3526529.002669382 3044243.5246523237 1.0 1.2745921135416434 1.1002798460710232 21.39978183470583 -10.286950082657045 3.7834633101243536 0.9996271089826998 1.1874359798493364 0.6065564234287596 0.07116268539329493 9223182.091981927 8473799.0839874 24972.397271054582 0.024360880579737926 5.1647572902817915e-11 10.286950082657045 0.18780887086663656 HTGYVGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HTGYVGLK 8 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 15633000.0 5162200.0 4300900.0 6169900.0 False True 7070804.843209566 4110872.016825627 4712696.693079194 1.0 0.5813867173513487 0.666500744622449 22.75344301027403 -10.133868027139588 5.44532513972336 1.0000072257412556 0.623943730986803 0.9630014395983134 0.034747656128289936 3.048161759845844e-06 4.848473031841737e-07 0.033644919326917086 0.011214757791997366 7.347371052234464e-11 10.133868027139588 -0.37606349475445255 HTGYVGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HTGYVGLK 8 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 8292200.0 2857500.0 3637700.0 1797000.0 False True 2376137.858713846 3618102.988073081 2172744.3916107686 1.0 1.522682269803775 0.9144016554606936 21.180187110140107 -6.6792581003829214 1.9042672441590467 1.3309195239256677 0.9167149563046555 0.32086232000090475 0.2215598361980447 0.4401628745028027 3.0852527030647066 0.09337632879204837 0.24653125138221532 2.0928682985460931e-07 6.6792581003829214 -0.4142045676210122 HTIAVVWGGVNIPHSPYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTIAVVWGGVNIPHSPYR 18 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 11619860.0 3666050.0 3301100.0 4652710.0 False True 4806227.052078704 2808588.7475870135 4171292.2011457873 1.0 0.5843645581355322 0.8678932884250015 22.196473374090438 -10.191912394912473 5.518127644065795 1.000009515149512 0.7261289232802415 0.5543766143425295 0.1157501194381553 1.3550234356183325e-05 1.98428742477493e-06 0.11207846419495039 0.03735819040877821 6.428173721827767e-11 10.191912394912473 -0.2738805918692706 HTIAVVWGGVNIPHSPYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HTIAVVWGGVNIPHSPYR 18 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 15258400.0 8116800.0 4478200.0 2663400.0 False True 7859136.626911687 6266368.613504486 1965775.6397126976 1.0 0.797335497648284 0.25012615673092903 22.905939401847768 -6.953791616817279 0.5155407221466566 1.0096294402829755 0.013597359201251881 0.9994662232702123 0.007317444440951206 0.08199800731428854 0.029930753035881805 0.008349839769084546 0.04518137467456634 1.1122652864062112e-07 6.953791616817279 -0.9960320810817236 down HTIAVVWGGVNIPHSPYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HTIAVVWGGVNIPHSPYR 18 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 81334600.0 31205000.0 11694000.0 38435600.0 False True 47340266.39108016 9607114.33436098 30838786.813078042 1.0 0.20293747937529877 0.6514282483819879 25.49656448857745 -10.595348069667242 9.51193975637368 1.0000810936483904 0.4271828639048216 0.6850415862397574 0.18309558973580412 0.000314920177540726 1.3397024894680185e-05 0.17730607997151615 0.059093847484232874 2.5389370333597263e-11 10.595348069667242 -0.5728982297435687 HTIAVVWGGVNIPHSPYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HTIAVVWGGVNIPHSPYR 18 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 18423250.0 3666050.0 7839700.0 6917500.0 False True 5021487.756276094 7493316.131578953 5283728.970384506 1.0 1.4922502045760144 1.0522238083286473 22.25968343561333 -10.361985480665169 3.714273889603774 0.9988432521409145 1.2722370065068718 0.3379056619593137 0.17964002424004663 22931046.364480216 21326243.252340175 191469.3771972986 0.06149555865149361 4.3452475096192765e-11 10.361985480665169 0.27339375436595725 HTIAVVWGGVNIPHSPYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HTIAVVWGGVNIPHSPYR 18 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 17202600.0 8116800.0 5912700.0 3173100.0 False True 6749478.835208593 5880847.111520937 3836580.5392432585 1.0 0.8713038821373219 0.5684261900681534 22.686344677282044 -6.956743479193343 0.4791356388238119 1.0073293905295277 0.4197914949870276 0.9996296772444478 0.003481372317157148 0.08088569869715302 0.02559108442732978 0.004263026854230813 0.024985611096264123 1.1047309487013401e-07 6.956743479193343 -0.5875378955425001 HTIAVVWGGVNIPHSPYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HTIAVVWGGVNIPHSPYR 18 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 58013000.0 31205000.0 26808000.0 0.0 False True 40395487.64250997 25316111.233874094 0.0 1.0 0.626706414783636 0.0 25.2676908106699 -7.587460878848053 0.6824280250734258 0.9959996360778434 7.334507093931127e-21 0.9871032601461907 0.04685582058657121 0.12108595960427623 0.1460247218776926 0.0422493664775749 0.07696636770326888 2.5854677274402185e-08 7.587460878848053 -0.9959996360778434 down HTLDELNPQK(ub)SK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTLDELNPQKSK 12 1 Q13131-2;Q13131 Q13131-2 PRKAA1 5-AMP-activated protein kinase catalytic subunit alpha-1 1 2041660.0 549580.0 1129600.0 362480.0 True False 720504.7021402906 961068.0831463126 324974.0467536823 1.0 1.3338817641181493 0.45103667719077023 19.4586483201489 -6.804232816528274 1.4385352847646622 1.1832399067203605 0.43753250978594993 0.8442615851731174 0.14363519558611895 0.21476928679813206 0.8769333667016642 0.07853411650624816 0.18219400215616127 1.5695211900560153e-07 6.804232816528274 -0.7457073969344106 down HTLDELNPQK(ub)SK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HTLDELNPQKSK 12 1 Q13131-2;Q13131 Q13131-2 PRKAA1 5-AMP-activated protein kinase catalytic subunit alpha-1 1 5139200.0 1004100.0 1835800.0 2299300.0 True False 972225.3951165517 2568844.5135705275 1697044.3524785636 1.0 2.642231448050759 1.7455256373704573 19.890931293124314 -10.06300732593633 6.325484879782427 0.9999985873899182 2.19387854271062 0.7026923118509094 0.36607861425928906 7.292570720654129e-06 1.0804921100201654e-06 0.35445451649661686 0.11815136470240326 8.649533281080275e-11 10.06300732593633 1.193879955320702 HTLDELNPQK(ub)SK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HTLDELNPQKSK 12 1 Q13131-2;Q13131 Q13131-2 PRKAA1 5-AMP-activated protein kinase catalytic subunit alpha-1 1 3991300.0 1004100.0 1860900.0 1126300.0 True False 834953.6391722045 1850874.9623402702 1361804.1225771909 1.0 2.216739799080674 1.6309936967606011 19.67133656855859 -10.130794852750832 5.3795424732663495 0.9999805159286796 1.9238667479210079 0.7683548371332709 0.2391298449193405 5.5881745059813916e-05 9.029928324247507e-06 0.2315413484375498 0.07717882557929272 7.399547241887576e-11 10.130794852750832 0.9238862319923282 HTLGHLLSLDSYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTLGHLLSLDSYR 13 0 Q02809;Q02809-2 Q02809 PLOD1 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 0 16444100.0 6424200.0 4324900.0 5695000.0 False True 8422188.412041292 3679641.778328163 5105736.03029745 1.0 0.4368985349540911 0.6062243897319758 23.00576371959693 -10.90945510034989 11.424163194330509 1.0442004249021037 0.5215614623430335 0.9141260217051858 0.06912699074440376 0.03615929180405897 0.00028658849231654013 0.031099443057014144 0.022310640327209183 1.2318133305010904e-11 10.90945510034989 -0.5226389625590703 HTLGHLLSLDSYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HTLGHLLSLDSYR 13 0 Q02809;Q02809-2 Q02809 PLOD1 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 0 15472500.0 6424200.0 4056700.0 4991600.0 False True 8799400.347477214 3877461.580287037 3812686.885228958 1.0 0.4406506610872301 0.4332893986715872 23.068973781119823 HTLTQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTLTQIK 7 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 6340700.0 1789300.0 2290600.0 2260800.0 False True 2345789.62760585 1948851.4086888703 2026874.1031249308 1.0 0.8307869494153655 0.864047687513049 21.161642206382588 -10.282686844035803 5.554336413946866 1.0000158236497227 0.847417318464205 0.965588262696122 0.013578639467958616 2.660968486234456e-06 3.436555900324204e-07 0.013148823869763458 0.004382487043627969 5.21570663593315e-11 10.282686844035803 -0.15259850518551776 HTLTQIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HTLTQIK 7 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 4806900.0 1789300.0 1877600.0 1140000.0 False True 2450852.564014352 1794641.4236071052 870755.4790369833 1.0 0.7322518906105018 0.3552867650311601 21.22485226790548 -6.966288720031439 0.3351980739540624 1.0432298902405865 0.03187169352874105 0.999937298841984 0.002094085593832872 0.0775263047275475 0.013332625228286793 0.005403250060962893 0.03274559962622737 1.0807152502915007e-07 6.966288720031439 -1.0113581967118455 down HTLTQIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HTLTQIK 7 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 3314870.0 1507800.0 989450.0 817620.0 False True 1253802.5068656995 984119.6364595523 988580.5617522531 1.0 0.7849080146758439 0.7884659317068541 20.257878688752715 -9.96402056877996 5.358772977689512 1.0000005990164906 0.7866869731906392 0.9997913903496031 0.001452513548123525 1.0394330129135753e-08 2.008183850250067e-09 0.0014063941446731969 0.00046879673145929033 1.0863741702338082e-10 9.96402056877996 -0.21331362582585145 HTLTQIK(ub)DAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HTLTQIKDAVR 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 3036700.0 665740.0 956160.0 1414800.0 True False 553592.3072826451 951008.9762971009 1710628.1387039043 1.0 1.7178869066393088 3.0900504147188532 19.078464369863962 -6.960921341044973 0.42224811898502407 0.9407958593098678 3.9190943001956633 0.9998028588626746 0.012174455038238689 0.07937362765548012 0.019927264198041885 0.017776997731340272 0.11415239078279392 1.0941545204307736e-07 6.960921341044973 2.9782984408857955 HTLVMFYAPWCPHCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTLVMFYAPWCPHCK 15 0 Q14554 Q14554 PDIA5 Protein disulfide-isomerase A5 0 4698700.0 1633000.0 1895400.0 1170300.0 False True 2140878.8139944957 1612613.7082113337 1049208.5823102926 1.0 0.7532484779941775 0.49008312635532025 21.029771702554655 -6.970307540440106 0.2507391666102731 1.082760614428075 0.15285605049349066 0.999984680166099 0.0008149198065397116 0.07620311262580477 0.008672704130355407 0.005840288355166314 0.025191543733207235 1.0707607902629495e-07 6.970307540440106 -0.9299045639345844 down HTLVMFYAPWCPHCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HTLVMFYAPWCPHCK 15 0 Q14554 Q14554 PDIA5 Protein disulfide-isomerase A5 0 6108200.0 1633000.0 2299900.0 2175300.0 False True 2236764.230165671 2198282.813247756 1661538.9417097834 1.0 0.9827959440700351 0.7428315060218562 21.092981764077546 -6.921338677159457 0.8147426401769928 1.0050435441433119 0.7029187203473742 0.9945446339228121 0.008670155999422618 0.09739052802674295 0.10158156259655077 0.007523662806007477 0.022833402985159623 1.198564258671498e-07 6.921338677159457 -0.30212482379593764 HTLVTCDK(ub)GVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HTLVTCDKGVFR 12 1 Q14094;Q14094-2;H0YA27 Q14094 CCNI Cyclin-I 1 11881300.0 1403800.0 2300900.0 8176600.0 True False 1167321.898884516 2288504.59500711 9886289.255673135 1.0 1.9604743106370126 8.469205679359222 20.154771020589738 -6.933317280024478 0.719040589548997 0.9121650128033533 9.925774056042323 0.9971509829869839 0.17709593323451503 0.09095170367965627 0.06950757680364882 0.16465284213808917 0.5785621200241776 1.165957498964146e-07 6.933317280024478 9.01360904323897 HTMMFSATFPK ddPTM_RPMI8226_Bortezomib_1h_R1 2 HTMMFSATFPK 11 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 169145400.0 53860500.0 56420700.0 58864200.0 False True 70611637.08582397 48002951.4861661 52773497.24927757 1.0 0.6798164363166025 0.7473767699952166 26.073402629329863 -10.841479819819956 7.307649009145665 1.019886956644183 0.7135966031559096 0.9599380812541664 0.02758139072746237 0.00859616846329376 0.0001864709715856595 0.025688734293269726 0.008901855579391783 1.4405229448684254e-11 10.841479819819956 -0.3062903534882735 HTMMFSATFPK ddPTM_RPMI8226_Bortezomib_2h_R1 2 HTMMFSATFPK 11 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 185794900.0 60286800.0 30670200.0 94837900.0 False True 58373028.53332594 42916970.80298008 69997008.91398543 1.0 0.7352191908027902 1.199132727438036 25.79879858486727 -6.751895741858234 1.6428675165013291 0.8446629722933335 1.200188101837116 0.6570915308507068 0.11127437368648217 0.2967405920921902 1.5763535486139832 0.053492946420540345 0.12960701686300352 1.770533947424605e-07 6.751895741858234 0.35552512954378257 HTMMFSATFPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HTMMFSATFPK 11 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 207051000.0 57123000.0 69231000.0 80697000.0 False True 86659767.25068642 56876187.1457281 64747202.579248466 1.0 0.6563159462591055 0.7471425856931968 26.368859026060974 -9.969094411859198 6.706261853084714 1.0000000363988637 0.7017292659761499 0.9349769434474678 0.03707982027755303 2.017788356415308e-08 3.11119744279871e-09 0.03590238588371459 0.011967460534609462 1.0737559617201813e-10 9.969094411859198 -0.29827077042271377 HTMMFSATFPK ddPTM_RPMI8226_Carfilzomib_1h_R1 3 HTMMFSATFPK 11 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 212860200.0 59198900.0 65906600.0 87754700.0 False True 81086333.12011907 62994628.48801885 67028847.22477787 1.0 0.7768834286130604 0.8266355703307384 26.27295543683694 -10.751802718939508 6.915801810135261 1.0038081073245722 0.8017594994719016 0.9548919234095068 0.020311226803157906 0.0012110598458883249 4.346298979967565e-05 0.01997090123467383 0.006555420262472681 1.7709132243494768e-11 10.751802718939508 -0.20204860785267054 HTMMFSATFPK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 HTMMFSATFPK 11 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 121518100.0 60286800.0 28581300.0 32650000.0 False True 50131145.358078785 28427326.863956172 39476964.04345664 1.0 0.5670591936590378 0.787473810172877 25.579203860301547 -10.064062057516441 4.822418337485507 1.0000098937219606 0.6772665019117038 0.7408353986271119 0.08998389039967868 124827378.9583107 5.36594226430133 13713.475498847962 0.03080387911277454 8.628552432315223e-11 10.064062057516441 -0.3227433918102568 HTMMFSATFPK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 HTMMFSATFPK 11 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 285433000.0 60153000.0 137540300.0 87739700.0 False True 77869244.29289864 129886061.39735936 71771974.88534677 1.0 1.668002079342183 0.921698618460743 26.21455028944969 -6.670775894334996 1.9349500104205504 1.4261146708753005 0.924729926148644 0.2822959457009542 0.28370522522568375 0.4593709314112352 3.3166439000925254 0.11801614058042581 0.31495328532417327 2.134145896065569e-07 6.670775894334996 -0.5013847447266565 HTNYTMEHIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTNYTMEHIR 10 0 A0A494C1A0;P35609-2;P35609;F6THM6;A0A494C060;O43707;O43707-2;O43707-3;F5GXS2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;H7C144;H7C5W8;H0YJW3;H0YJ11 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1 0 9639700.0 1963000.0 4362800.0 3313900.0 False True 2573512.009719038 3711887.2460612077 2971009.4171734373 1.0 1.4423430829322035 1.15445717989783 21.29530708445913 -10.246170812093021 4.957183788239814 0.9999453160827672 1.2984001314147275 0.5889010478385985 0.11752892776332204 7.10541502262649e-05 1.0805170731959975e-05 0.11381770742280974 0.037932298326952364 5.67321428683812e-11 10.246170812093021 0.2984548153319604 HTNYTMEHIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HTNYTMEHIR 10 0 A0A494C1A0;P35609-2;P35609;F6THM6;A0A494C060;O43707;O43707-2;O43707-3;F5GXS2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;H7C144;H7C5W8;H0YJW3;H0YJ11 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1 0 5591100.0 1481700.0 1835500.0 2273900.0 False True 1434664.2445415752 2568424.722006049 1678297.374462232 1.0 1.7902618900401672 1.1698189181528713 20.45228171081623 -10.096487266045347 4.466753151848969 0.9999611604339098 1.4800404035903763 0.44387631611758227 0.2532947827069466 38697767.93264724 43735525.845718935 13572.904980475447 0.0867095431562142 8.007791078180385e-11 10.096487266045347 0.48007924315646644 HTNYTMEHIR ddPTM_RPMI8226_Bortezomib_8h_R1 2 HTNYTMEHIR 10 0 A0A494C1A0;P35609-2;P35609;F6THM6;A0A494C060;O43707;O43707-2;O43707-3;F5GXS2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;H7C144;H7C5W8;H0YJW3;H0YJ11 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1 0 32238800.0 7228800.0 17525700.0 7484300.0 False True 10966618.096069233 14398101.90608089 6005024.824514784 1.0 1.3129026450954469 0.5475730778540712 23.386615357841606 -6.795719994675946 1.4735216940420288 1.1735924400781135 0.5381158824372173 0.8192804546684748 0.133557373183725 0.22693526183835672 0.9731975573222588 0.0713230958578209 0.16630780385785515 1.6005896539232644e-07 6.795719994675946 -0.6354765576408962 HTNYTMEHIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HTNYTMEHIR 10 0 A0A494C1A0;P35609-2;P35609;F6THM6;A0A494C060;O43707;O43707-2;O43707-3;F5GXS2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;H7C144;H7C5W8;H0YJW3;H0YJ11 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1 0 10565200.0 1963000.0 3615200.0 4987000.0 False True 2688774.1480803466 3455468.5101322993 3809173.31048898 1.0 1.2851464347049508 1.4166951557491518 21.35851714598202 -12.591403583062856 0.11792406718852812 1.2334309482076645e-15 1.6497619717962464 0.999744933749135 0.0027777105045515434 7.191538720523535 0.09139212141413142 1.905404216829744 0.18688386847091173 2.5621020086133684e-13 12.591403583062856 1.649761971796245 HTNYTMEHIR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 HTNYTMEHIR 10 0 A0A494C1A0;P35609-2;P35609;F6THM6;A0A494C060;O43707;O43707-2;O43707-3;F5GXS2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;H7C144;H7C5W8;H0YJW3;H0YJ11 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1 0 7389980.0 1912070.0 3289960.0 2187950.0 False True 1589970.924063337 3272236.3324740683 2645440.229062203 1.0 2.0580479070092212 1.663829312237675 20.600568952385263 -10.119112251731806 4.584631403515303 0.9999259329491714 1.8609386096406089 0.8641173977152166 0.16093906747526646 112239489.00435652 14.891079074241938 93344.79840135037 0.05509372351123276 7.601297814378785e-11 10.119112251731806 0.8610126766914374 HTNYTMEHIR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 HTNYTMEHIR 10 0 A0A494C1A0;P35609-2;P35609;F6THM6;A0A494C060;O43707;O43707-2;O43707-3;F5GXS2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;H7C144;H7C5W8;H0YJW3;H0YJ11 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1 0 23602600.0 7228800.0 7702600.0 8671200.0 False True 9357824.100951008 7273943.538870433 7093130.57402543 1.0 0.7773114198771062 0.7579893036570944 23.157741679934055 -13.999999999999998 0.34614001284498214 3.6742709458880625 0.7551817865409662 0.999747283956867 0.0017457141454159243 20.281682094361187 0.1891244835635272 39.80656109884544 0.005842166419662402 1.0000000000000041e-14 13.999999999999998 -2.919089159347096 HTPLSK(ub)LMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTPLSKLMK 9 1 A8MUA9;A8MU27;P55854;P55854-2;P61956-2;P61956 A8MUA9;P61956-2 SUMO3;SUMO2 Small ubiquitin-related modifier 3;Small ubiquitin-related modifier 2 1 2565050.0 663970.0 862780.0 1038300.0 True False 870471.0998946268 734056.5870900986 930866.6760768818 1.0 0.8432865688234319 1.0693826322201463 19.731436874862496 -6.720239681667403 1.7582045028469586 0.9046844077448676 1.0690412606226043 0.5137822987591341 0.06594346735059146 0.35484111495335796 2.1438088339611836 0.029777353240187057 0.07473822443868752 1.9044094082652014e-07 6.720239681667403 0.16435685287773671 HTPLSK(ub)LMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HTPLSKLMK 9 1 A8MUA9;A8MU27;P55854;P55854-2;P61956-2;P61956 A8MUA9;P61956-2 SUMO3;SUMO2 Small ubiquitin-related modifier 3;Small ubiquitin-related modifier 2 1 32278900.0 4380200.0 6874700.0 21024000.0 True False 4241152.948600258 9619803.56108689 15517183.69351948 1.0 2.2682048201684855 3.6587182498666415 22.016025081074428 -6.969943002775825 0.25954488888529564 0.6074366720048063 5.360716297422864 0.9999819345003137 0.004615029346641987 0.07632121085962329 0.009096347260128377 0.029112849938126982 0.13128683530327742 1.0716599416869508e-07 6.969943002775825 4.753279625418058 HTPLSK(ub)LMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HTPLSKLMK 9 1 A8MUA9;A8MU27;P55854;P55854-2;P61956-2;P61956 A8MUA9;P61956-2 SUMO3;SUMO2 Small ubiquitin-related modifier 3;Small ubiquitin-related modifier 2 1 11277700.0 3184200.0 3040100.0 5053400.0 True False 4361484.789769464 2905778.329733681 3859890.9980399096 1.0 0.6662360342399067 0.8849947171875687 22.05638792776126 -10.475735762884351 4.9554165486277055 1.000566298508227 0.7756153757137234 0.5838180755019657 0.08930785833755872 0.0005601360002399194 5.9260242667786e-05 0.08668656908396545 0.028823987335560942 3.3439843566371654e-11 10.475735762884351 -0.22495092279450368 HTPLSK(ub)LMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HTPLSKLMK 9 1 A8MUA9;A8MU27;P55854;P55854-2;P61956-2;P61956 A8MUA9;P61956-2 SUMO3;SUMO2 Small ubiquitin-related modifier 3;Small ubiquitin-related modifier 2 1 22349300.0 4380200.0 9224100.0 8745000.0 True False 3642330.3757614675 9174407.942459494 10573539.067688465 1.0 2.518829154958654 2.9029599121628156 21.796430356508704 -10.080684195799664 0.32604857296242346 1.8506810556938874e-14 3.004955029722228 0.9988865914728517 0.02741590300505416 1.4814433861006426 0.14772401935717408 1.4897062658073341 0.12352907358786211 8.304544262676186e-11 10.080684195799664 3.0049550297222094 HTPLSK(ub)LMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HTPLSKLMK 9 1 A8MUA9;A8MU27;P55854;P55854-2;P61956-2;P61956 A8MUA9;P61956-2 SUMO3;SUMO2 Small ubiquitin-related modifier 3;Small ubiquitin-related modifier 2 1 100664800.0 2483000.0 2445000.0 95736800.0 True False 3214292.447247312 2308933.600672267 78313684.74252218 1.0 0.7183333932945692 24.36420643976849 21.616069765605175 -6.90420342872293 0.9342925571253397 0.12702697603025134 27.069650642574842 0.988544515958181 1.1860004135781914 0.10837760204385467 0.16047618771610508 0.9439843245577201 2.5122138488722374 1.2467993617276823e-07 6.90420342872293 26.94262366654459 up HTQEAMEK(ub)ENLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTQEAMEKENLR 12 1 A0A0A0MR07;P15498;F5H5P4;Q96D37;P15498-2 A0A0A0MR07 VAV1 Proto-oncogene vav 1 2516500.0 502970.0 343330.0 1670200.0 True False 659398.5407684094 292106.5022898579 1497383.7256896957 1.0 0.44298930651175045 2.2708326347594987 19.330791168802545 -6.824941881048764 1.3504464748348197 0.7011873138084942 2.315099015905249 0.8953618600317557 0.24744349577790353 0.18713299024615818 0.6692082968889175 0.14393868294002748 0.3313856667234376 1.496435901480121e-07 6.824941881048764 1.6139117020967548 up HTQENCETWGVNGETGTLVDMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTQENCETWGVNGETGTLVDMK 22 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 17299400.0 3038100.0 7317500.0 6943800.0 False True 3982978.521002253 6225757.523391596 6225322.185632922 1.0 1.5630909106245905 1.5629816110749246 21.925416269029515 -10.032971805220262 4.442040659033056 0.9999714934053833 1.5630362609126343 0.9999999712631011 4.4621568561481646e-05 31098.184277368753 55074.16961994507 12.484340851228533 1.6329784823499638e-05 9.268899959398599e-11 10.032971805220262 0.563064767507251 HTQENCETWGVNGETGTLVDMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HTQENCETWGVNGETGTLVDMK 22 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 21435200.0 3038100.0 10001000.0 8396100.0 False True 4161367.6715654177 9559122.751115602 6413114.103107384 1.0 2.2971108312377657 1.5411073015557186 21.988626330552407 -10.25138071135356 5.43697731221674 0.9999218184496678 1.9191090663967634 0.6633814047851294 0.30863714857755764 0.00029254001410161667 4.0279843151138905e-05 0.2988617668679614 0.0996122113717875 5.60556365503816e-11 10.25138071135356 0.9191872479470956 HTQFWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTQFWR 6 0 P12236 P12236 SLC25A6 ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed 0 11820600.0 3835200.0 4279300.0 3706100.0 False True 5027984.340129627 3640845.120580756 3322628.3234214922 1.0 0.7241162410794006 0.6608271026030744 22.26154872575473 -13.999999999999998 0.2068533986413656 2.5752610021451163 0.6223925822626928 0.9994884864758503 0.003330406014270872 12.674864781214989 0.1441771460780318 8.102627880538709 0.03833324719832206 1.0000000000000041e-14 13.999999999999998 -1.9528684198824235 HTQFWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HTQFWR 6 0 P12236 P12236 SLC25A6 ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed 0 7064900.0 1849400.0 1843400.0 3372100.0 False True 1790691.8093103776 2579479.2332040076 2488845.84916843 1.0 1.4404931210342689 1.3898795070308174 20.77208563002106 -10.48419225969066 6.041312708541058 0.9996822488199943 1.4151863140325431 0.9889770923638981 0.020662921391107068 8.849846809927353e-05 7.556012826794225e-06 0.020021705982671615 0.0066689292026458685 3.279500793427819e-11 10.48419225969066 0.4155040652125488 HTQFWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HTQFWR 6 0 P12236 P12236 SLC25A6 ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed 0 12999600.0 3835200.0 4035600.0 5128800.0 False True 5253177.082382958 3857293.848055408 3917483.070951649 1.0 0.7342782829444716 0.7457359631163607 22.32475878727762 -10.558525649774639 6.8084117488231115 1.0002565797022862 0.7400071230304162 0.9985455449817843 0.004677578342855419 1.8235277259935338e-05 1.1824131649872537e-06 0.0045334419282741225 0.0015096819185382974 2.7635946942679648e-11 10.558525649774639 -0.26024945667187005 HTQFWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HTQFWR 6 0 P12236 P12236 SLC25A6 ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed 0 11309000.0 1849400.0 6772400.0 2687200.0 False True 1537858.0423115971 6735915.736983856 3249081.095791021 1.0 4.380063407451389 2.1127314787177864 20.552490905455336 -9.554271940568388 10.30969897108142 0.9999646480023932 3.2463974430845877 0.5668793352845234 0.9256343840446547 0.0 0.0 0.8962416384187983 0.29874721280626604 2.7907957917375743e-10 9.554271940568388 2.2464327950821943 HTQFWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HTQFWR 6 0 P12236 P12236 SLC25A6 ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed 0 17555900.0 5754700.0 5020400.0 6780800.0 False True 7449572.592095887 4741010.326713721 5546763.976883431 1.0 0.6364137362382383 0.7445747938302708 22.82872622483828 -10.444477929665961 8.810917999407575 1.0000039446574194 0.690494265034255 0.9160917449903293 0.04415656685671072 3.4216684896876545e-06 2.156970584662108e-07 0.0427549570950683 0.01425147067181126 3.593536582210208e-11 10.444477929665961 -0.30950967962316434 HTSVQTTSSGSGPFTDVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTSVQTTSSGSGPFTDVR 18 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 9044800.0 2179100.0 3791400.0 3074300.0 False True 2856821.20243442 3225737.898761445 2756200.9267679467 1.0 1.1291353816656973 0.9647789383596248 21.445979315632382 -6.697235095655711 1.841427535595517 1.0804072508639995 0.9653034428003177 0.4041878692438172 0.054538006346430176 0.4012803295444372 2.643555126415598 0.023649353896121786 0.061012569908444905 2.0080055292272669e-07 6.697235095655711 -0.11510380806368181 HTSVQTTSSGSGPFTDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HTSVQTTSSGSGPFTDVR 18 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 8336500.0 2179100.0 2771200.0 3386200.0 False True 2984772.157963268 2648759.220867071 2586449.300978103 1.0 0.8874242591014103 0.8665483206406716 21.509189377155273 -13.99999999999993 0.23696520914166425 1.7343370692135585 0.857048314699369 0.9995200472879018 0.0012840515522917683 13.518268829093504 0.1540871413360338 4.689216936987325 0.010385936906337302 1.0000000000001595e-14 13.99999999999993 -0.8772887545141894 HTTSIFDDFSHYEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTTSIFDDFSHYEK 14 0 Q9Y5A9;Q9Y5A9-2 Q9Y5A9 YTHDF2 YTH domain-containing family protein 2 0 9894600.0 2191200.0 4713100.0 2990300.0 False True 2872684.419610982 4009923.8515199106 2680892.440983048 1.0 1.395880391227566 0.9332359735310202 21.453968082810974 -6.680117557468872 1.901196836303452 1.2504451899419486 0.9349828858086429 0.32480623294210664 0.16777804256983303 0.4382482813572895 3.0626725206290404 0.07080459675636448 0.18673291579255916 2.0887306640194926e-07 6.680117557468872 -0.3154623041333058 HTTSIFDDFSHYEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HTTSIFDDFSHYEK 14 0 Q9Y5A9;Q9Y5A9-2 Q9Y5A9 YTHDF2 YTH domain-containing family protein 2 0 8027900.0 3003700.0 1401500.0 3622700.0 False True 2908349.1876422535 1961126.2587259496 2673806.191329577 1.0 0.6743090778297497 0.9193552832963582 21.47176906452262 -10.365089598253308 5.5023809947540965 1.0000652128000933 0.7968321805630683 0.47822706908143475 0.10003969446640745 8.005712522744768e-05 9.237664743806154e-06 0.09689404213822767 0.03228767255233835 4.3143006034432895e-11 10.365089598253308 -0.20323303223702505 HTTSIFDDFSHYEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HTTSIFDDFSHYEK 14 0 Q9Y5A9;Q9Y5A9-2 Q9Y5A9 YTHDF2 YTH domain-containing family protein 2 0 36611600.0 0.0 30352000.0 6259600.0 False True 0.0 24935448.458741613 5022387.316319854 0.0 HTTSIFDDFSHYEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HTTSIFDDFSHYEK 14 0 Q9Y5A9;Q9Y5A9-2 Q9Y5A9 YTHDF2 YTH domain-containing family protein 2 0 12417900.0 2191200.0 4631600.0 5595100.0 False True 3001345.8549534674 4426960.597346975 4273652.614701605 1.0 1.4749918240980628 1.4239120785258064 21.517178144333865 -10.444310843847852 5.975585986158243 0.9997851601027353 1.4494519513119348 0.9904058740751479 0.020853218807203235 5.971371270997019e-05 5.552955727734014e-06 0.020200515907076333 0.006730347429593059 3.594919387060145e-11 10.444310843847852 0.4496667912091995 HTVGLSK(ub)LSLELYPAPLESYDTQGALCWGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HTVGLSKLSLELYPAPLESYDTQGALCWGR 30 1 Q5VWM4;Q5VXH5 Q5VWM4 PRAMEF8;PRAMEF7 PRAME family member 8;PRAME family member 7 1 59348900.0 7654900.0 15037000.0 36657000.0 True False 11613042.948151888 12353529.865382744 29411727.882666133 1.0 1.0637633840274996 2.5326460957717156 23.469242713159165 -6.916002744509323 0.8538398600193003 0.9626906566082418 2.7490341914081853 0.9929967524252579 0.059244739294852425 0.10058131082426629 0.11822119377051886 0.04999293302432983 0.14448056621924957 1.2133811825193108e-07 6.916002744509323 1.7863435347999435 up HTVTMIPGDGIGPELMLHVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HTVTMIPGDGIGPELMLHVK 20 0 E9PF84;E7EQB8;P51553-2;P51553 E9PF84 IDH3G Isocitrate dehydrogenase [NAD] subunit, mitochondrial;Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial 0 5464200.0 1378100.0 1840300.0 2245800.0 False True 1887620.8117521827 1758989.4609417093 1715388.29370286 1.0 0.9318553016529462 0.9087568239463052 20.848137552272103 -13.999999999996671 0.15105262485853768 1.3300535371175357 0.8836489120382198 0.9995627422918186 0.0008099243555430757 11.961813400800489 0.12245535289241491 1.158455234814861 0.02265419164454343 1.000000000007665e-14 13.999999999996671 -0.4464046250793159 HTVYNIITNFMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTVYNIITNFMR 12 0 Q96T76-9;Q96T76;Q96T76-8;Q96T76-5;Q5T454;Q96T76-7;F8WCH8;B0QZ77 Q96T76-9 MMS19 MMS19 nucleotide excision repair protein homolog 0 12510200.0 2348100.0 5486600.0 4675500.0 False True 3078381.839032746 4668020.666599292 4191724.11056291 1.0 1.5163878006979228 1.3616647738150591 21.55374076236536 -9.982721622417724 4.677378003926454 0.9999929943396676 1.4390262871357162 0.9147862365246123 0.0631654113168428 43458033.71998497 0.23442566875493898 3585.794589237528 0.021623200380710726 1.040586955929747e-10 9.982721622417724 0.43903329279604864 HTVYNIITNFMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HTVYNIITNFMR 12 0 Q96T76-9;Q96T76;Q96T76-8;Q96T76-5;Q5T454;Q96T76-7;F8WCH8;B0QZ77 Q96T76-9 MMS19 MMS19 nucleotide excision repair protein homolog 0 18447100.0 6807200.0 4004600.0 7635300.0 False True 6591109.162072901 5603657.6637131125 5635385.875909873 1.0 0.8501843204112196 0.8549981099292774 22.65208983394657 -10.380785657224905 5.740908592678513 1.0000410835847944 0.8525912160687529 0.9992008188079323 0.0019652213414014046 1.0336784462814088e-06 1.1149024127518077e-07 0.0019033471429694174 0.0006342724605714617 4.161159307106097e-11 10.380785657224905 -0.1474498675160415 HTVYNIITNFMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HTVYNIITNFMR 12 0 Q96T76-9;Q96T76;Q96T76-8;Q96T76-5;Q5T454;Q96T76-7;F8WCH8;B0QZ77 Q96T76-9 MMS19 MMS19 nucleotide excision repair protein homolog 0 21866600.0 2348100.0 6531700.0 12986800.0 False True 3216256.02501654 6243107.896556531 9919585.311541662 1.0 1.9411103618607057 3.0842026363528223 21.616950823888253 -6.968526590810992 0.2912349931812749 0.7799211150702027 4.280769772831592 0.9999685011329168 0.004782887872823841 0.0767837354696693 0.010732523430077757 0.01983889532061478 0.10351350317244866 1.0751607688585251e-07 6.968526590810992 3.5008486577613893 HTVYNIITNFMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HTVYNIITNFMR 12 0 Q96T76-9;Q96T76;Q96T76-8;Q96T76-5;Q5T454;Q96T76-7;F8WCH8;B0QZ77 Q96T76-9 MMS19 MMS19 nucleotide excision repair protein homolog 0 24312300.0 6807200.0 5391800.0 12113300.0 False True 5660488.410091663 5362753.303211502 14646135.024428897 1.0 0.9474011630605318 2.5874330911653125 22.432495109380845 -6.899491246004833 0.9644925103814173 0.930858357377548 2.7578059950071534 0.9863110910856635 0.08903948958571302 0.11178025952157808 0.17954551658587634 0.06930537142822044 0.17986214837499867 1.2604010433137934e-07 6.899491246004833 1.8269476376296054 up HTYLANGQTK(ub)VLTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HTYLANGQTKVLTQK 15 1 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 22957600.0 1754400.0 2624200.0 18579000.0 True False 2300035.389633765 2232679.589051481 16656623.302352319 1.0 0.9707153199094866 7.241898701830216 21.13322462877919 -6.905849479482337 0.9235505857484317 0.7794366894206813 7.984283009325741 0.9892583970984733 0.30567938819138357 0.10722663992344428 0.1541343475877249 0.2452374445291696 0.6589837175062366 1.2420827218553196e-07 6.905849479482337 7.20484631990506 up HTYLANGQTK(ub)VLTQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HTYLANGQTKVLTQK 15 1 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 37630400.0 2203000.0 5573400.0 29854000.0 True False 2133066.9708612324 7798887.684897048 22034341.799197633 1.0 3.656185104093672 10.32988748135798 21.024497831304874 -6.955354836480827 0.4965949730182913 0.8623100619286761 13.40994155481207 0.9995572394885657 0.08258632140984369 0.08140418970681203 0.02759561011076475 0.09748408791832543 0.550467090965028 1.108268943867603e-07 6.955354836480827 12.547631492883394 HTYLANGQTK(ub)VLTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HTYLANGQTKVLTQK 15 1 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 27395600.0 1754400.0 2666200.0 22975000.0 True False 2403049.0908773104 2548398.4680556394 17548778.184977807 1.0 1.0604853965447973 7.302713145394405 21.19643469030208 -6.9090208902217265 0.902383885685507 0.8006927197869675 8.092727599769566 0.9905466342223375 0.2875019147480127 0.10506885039917424 0.1423084025528794 0.23424808169335037 0.6423212122513936 1.233045520447103e-07 6.9090208902217265 7.292034879982598 up HTYLANGQTK(ub)VLTQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HTYLANGQTKVLTQK 15 1 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 25603500.0 2203000.0 8067500.0 15333000.0 True False 1831892.1094476313 8024038.776226636 18539059.408218082 1.0 4.380191789049256 10.120169912085132 20.80490310673915 -6.963114095026467 0.3890674573663842 0.643787879775588 14.06250811846607 0.9998688316842477 0.04311559373706157 0.07860693165883413 0.017153925972244227 0.07414994247216432 0.4830288533253913 1.0886440542644063e-07 6.963114095026467 13.418720238690483 HTYLANGQTK(ub)VLTQK(ub)LSSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HTYLANGQTKVLTQKLSSVR 20 2 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 2 26181300.0 1640300.0 1858000.0 22683000.0 True False 1588229.574354827 2599909.089341997 16741641.82458632 1.0 1.6369856923223056 10.54107170330658 20.59898803460392 -6.921310136687964 0.8149515961991313 0.8126596112877688 12.021112592625 0.9945371438910394 0.3219078174966376 0.0974071119100719 0.10166492934977879 0.27929777361818464 0.8474004106226353 1.1986430271443082e-07 6.921310136687964 11.208452981337231 up HTYLANGQTK(ub)VLTQK(ub)LSSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HTYLANGQTKVLTQKLSSVR 20 2 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 2 11730900.0 1640300.0 2545400.0 7545200.0 True False 1363982.127610964 2531687.424977657 9122866.434936887 1.0 1.8561001451037684 6.688406138367612 20.379393310038196 -6.937140781187146 0.6856459514206764 0.9421494094355296 7.888767122336936 0.9977649241472115 0.11839306923703699 0.08909556551330806 0.06073298879752592 0.11288807562237457 0.4214127030643194 1.1557375368169388e-07 6.937140781187146 6.946617712901406 HVAAGTQQPYTDGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVAAGTQQPYTDGVR 15 0 P14923 P14923 JUP Junction plakoglobin 0 3007860.0 687460.0 1227200.0 1093200.0 False True 665636.9585965784 1717227.3597634549 806858.1247029826 1.0 2.5798257407221468 1.2121594425948843 19.34437601384087 -6.61123047356566 2.14944743647533 2.054643804442968 1.217129997380793 0.05409439595210208 0.6809096525079738 0.6093064473640379 5.336417808778784 0.26145236915130804 0.7556729442664349 2.4477639055261666e-07 6.61123047356566 -0.8375138070621748 HVALSVGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVALSVGGR 9 0 E5RFP0;Q8WVJ2 E5RFP0 NUDCD2 NudC domain-containing protein 2 0 11284100.0 3591000.0 2913900.0 4779200.0 False True 4707835.77529347 2479157.478293237 4284694.22932355 1.0 0.5266023703086148 0.910119730983279 22.16663256465762 -9.950145181044363 6.835068113350015 1.0000000187872635 0.7183610506459459 0.4182805643633696 0.15657030685864984 4.4952204370494306e-08 6.610013837448705e-09 0.15159855903849065 0.050532849247843854 1.121643435522194e-10 9.950145181044363 -0.2816389681413176 HVALSVGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVALSVGGR 9 0 E5RFP0;Q8WVJ2 E5RFP0 NUDCD2 NudC domain-containing protein 2 0 15863000.0 5239200.0 6695800.0 3928000.0 False True 7948249.436825747 5500882.175475819 3151629.0782964383 1.0 0.6920872601190885 0.39651864267046566 22.92220571816047 -7.127729620804982 0.2322575878627573 1.1259749821825216 1.4560197138258719e-12 0.9999846592277467 0.0009650156466320996 0.07982734815050523 0.00940830387769627 0.00972197303137492 0.03249158542015372 7.451957668701649e-08 7.127729620804982 -1.1259749821810656 down HVALSVGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVALSVGGR 9 0 E5RFP0;Q8WVJ2 E5RFP0 NUDCD2 NudC domain-containing protein 2 0 11831600.0 3591000.0 3196600.0 5044000.0 False True 4918689.743126104 3055363.6422573933 3852711.08444083 1.0 0.6211742967783811 0.7832799557697282 22.22984262618051 -10.183653805639715 5.352972534107075 1.0000127059275556 0.7022271278287004 0.8181476075274163 0.06617935815798419 1.0035590008162767e-05 1.5304072516574275e-06 0.06408062112951418 0.02135929600067811 6.55158220083598e-11 10.183653805639715 -0.2977855780988552 HVALSVGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVALSVGGR 9 0 E5RFP0;Q8WVJ2 E5RFP0 NUDCD2 NudC domain-containing protein 2 0 14656300.0 5239200.0 5139800.0 4277300.0 False True 6782247.680071734 4853765.611752679 3498875.2888041986 1.0 0.715657380961549 0.5158872771758155 22.69333204025292 -7.7914768991688295 0.1271886509576265 1.3906215467571064 8.985227924044707e-16 0.9999832638101709 0.0008126172946258769 0.1307990675860545 0.016942271109631934 0.07407543907400806 0.0985800298890384 1.616304197674133e-08 7.7914768991688295 -1.3906215467571055 HVAQFLIGTAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVAQFLIGTAQR 12 0 O60231;A0A140T947 O60231 DHX16 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 0 7410000.0 4037200.0 3372800.0 0.0 False True 5292808.296300411 2869591.387071428 0.0 1.0 0.5421680186447007 0.0 22.335601970324113 -7.804320836379969 0.620038879977416 1.0046532264856927 2.9708919126902595e-19 0.9880882202987283 0.044609454556173926 0.11670477975170414 0.15593290446128324 0.0434349780830379 0.07783861967410964 1.569203122409451e-08 7.804320836379969 -1.0046532264856927 down HVDAHATLNDGVVVQVMGLLSNNNQALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVDAHATLNDGVVVQVMGLLSNNNQALR 28 0 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 114609000.0 27282000.0 60551000.0 26776000.0 False True 41388788.58136356 49745200.96287769 21483711.863662302 1.0 1.2019003857792745 0.5190708063713644 25.30273668680158 -6.827502137387802 1.3389737693826285 1.1080861234438213 0.501609628826215 0.9007876958592435 0.09021561990985047 0.18392168172875098 0.6457575675935838 0.05291345374968522 0.12179199892651392 1.4876400526152427e-07 6.827502137387802 -0.6064764946176063 HVDAHATLNDGVVVQVMGLLSNNNQALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVDAHATLNDGVVVQVMGLLSNNNQALR 28 0 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 68498000.0 27282000.0 27796000.0 13420000.0 False True 35317086.80861906 26249128.16535226 10977697.700828169 1.0 0.7432416016528921 0.31083248061527785 25.07386300889403 -6.963262089663117 0.3867211283593854 1.0275466695451603 0.011071794406981451 0.9998727168776254 0.0032083793034740323 0.07855575941175277 0.016970806300768877 0.005594571078219655 0.036425210000803725 1.0882731399660611e-07 6.963262089663117 -1.016474875138179 down HVDWVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVDWVK 6 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;P40123;E9PDI2;F8WDB9 Q01518 CAP1;CAP2 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein;Adenylyl cyclase-associated protein 2 0 6126700.0 1347000.0 2978100.0 1801600.0 False True 1765930.0443665567 2533779.0885428786 1615187.7141674974 1.0 1.4348128322669493 0.9146385607516344 20.751996762455263 -6.684880169922937 1.8841999828930425 1.273885782840061 0.9165169939937523 0.34680121491367466 0.184088788789497 0.4277423214173897 2.9399519765545667 0.07827162886130418 0.20518074797584893 2.0659501119599264e-07 6.684880169922937 -0.3573687888463086 HVDWVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVDWVK 6 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;P40123;E9PDI2;F8WDB9 Q01518 CAP1;CAP2 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein;Adenylyl cyclase-associated protein 2 0 5820900.0 1347000.0 1761800.0 2712100.0 False True 1845022.3013062829 1683957.850506499 2071557.8374528121 1.0 0.9127032498817225 1.1227820043075583 20.815206823978155 -6.793842356615827 1.4809199681101606 0.9514527836979185 1.125259848558964 0.8135476239997514 0.03720882179101287 0.2296667716977903 0.9949129331516099 0.01977249821730006 0.046166630501944285 1.607524658167787e-07 6.793842356615827 0.17380706486104547 HVEAVAYYKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVEAVAYYKK 10 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 7858300.0 0.0 2545200.0 5313100.0 True False 0.0 3561511.6330426596 3921439.720416591 0.0 HVEAVAYYKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVEAVAYYKK 10 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 10301100.0 1132500.0 3622000.0 5546600.0 True False 1718085.296840196 2975625.8011848344 4450312.078838855 1.0 1.7319429987890793 2.5902742355246353 20.712370232269482 -6.969025417518628 0.28049272281263515 0.812023770764829 3.5363661115325553 0.9999737495029931 0.0033298235873300674 0.07662026136752635 0.010157391638412385 0.01580953351669622 0.07873512648466993 1.0739265578767701e-07 6.969025417518628 2.724342340767726 HVEEFSPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVEEFSPR 8 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 8272640.0 787540.0 4960100.0 2525000.0 False True 1032472.5665482086 4220072.414318364 2263737.221510287 1.0 4.087345805639204 2.1925398260977307 19.9776720181547 -9.805461242035292 6.420358437601465 0.9999999547509839 3.1399428158690914 0.6297180392546382 0.7735513019107487 5.053704437702857e-07 9.734724187561879e-08 0.7489878497545834 0.2496626091444534 1.5650879869407428e-10 9.805461242035292 2.1399428611181075 HVEEFSPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVEEFSPR 8 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 3768530.0 1095400.0 612830.0 2060300.0 False True 1060627.126591646 857536.214866232 1520645.6223248763 1.0 0.808518086485255 1.4337231098468244 20.016486121745167 -6.824496913506869 1.3522898719409984 0.8972352742318672 1.4487361683166962 0.8944212969839899 0.08498420464733618 0.1876995468998419 0.6731891308211015 0.0493685306382983 0.11367427853106456 1.4979698989489048e-07 6.824496913506869 0.5515008940848289 HVEEFSPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVEEFSPR 8 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 6341940.0 787540.0 2608800.0 2945600.0 False True 1078714.820468262 2493534.5898520574 2249909.946536263 1.0 2.311579059208283 2.0857319319665915 20.04088207967759 -10.196257088543197 4.566124138208582 0.9997438773302748 2.198655495600288 0.9740648062078936 0.09220170364848554 32396009.30507237 41.389189814847455 87289.020130793 0.031563095573570704 6.36418669732584e-11 10.196257088543197 1.1989116182700132 HVEFDFLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVEFDFLIK 9 0 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 0 8348800.0 3768900.0 1596100.0 2983800.0 False True 3649258.332491562 2233431.0535515444 2202253.267918731 1.0 0.6120232798171487 0.6034796847103789 21.799171852834277 HVEFDFLIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVEFDFLIK 9 0 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 0 55811000.0 14046000.0 21660000.0 20105000.0 False True 21308808.900147818 17794603.769647557 16131237.937665453 1.0 0.8350820476654666 0.7570220378462145 24.344946617169054 -13.999999994750846 0.099470219612842 1.8157351940200928 0.5893885669136761 0.9997963659521023 0.001445342998327735 12.084480538561621 0.09381751150307951 2.026292691891262 0.14955276381153604 1.0000000120866239e-14 13.999999994750846 -1.2263466271064165 HVEFDFLIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVEFDFLIK 9 0 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 0 7576300.0 3768900.0 1806600.0 2000800.0 False True 3134007.3405797496 1796867.4872179786 2419158.029346035 1.0 0.5733450154860141 0.7719056678720232 21.579577128268554 -10.082014246170653 4.83562940839353 1.0000107710018946 0.6726253416772899 0.7837582072427072 0.08106204690408916 112651415.51108219 2.117115241984079 14942.006173267282 0.02774969477716606 8.27915005154276e-11 10.082014246170653 -0.3273854293246047 HVEFDFLIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVEFDFLIK 9 0 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 0 50348000.0 14046000.0 22018000.0 14284000.0 False True 18182823.888053056 20792678.94462249 11684458.56621681 1.0 1.1435340886892837 0.6426096759312524 24.116072939261503 -6.830118835338051 1.3275394434388197 1.076686551053552 0.6291125934974255 0.9060817724093609 0.06454742904264846 0.1806658018112322 0.622688389497659 0.03817712867971576 0.08784871955167275 1.4787037173585326e-07 6.830118835338051 -0.4475739575561264 HVFAIFNTEQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVFAIFNTEQR 11 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 0 8017900.0 3944400.0 0.0 4073500.0 False True 5171146.59762394 0.0 3652013.295771148 1.0 0.0 0.706228923668339 22.302052773907064 -10.554411685989342 8.595278454678985 1.0000956911571104 0.35311446408073127 0.5280061380605434 0.2883167507637334 0.0005287693485731382 2.741166837341433e-05 0.2792017865609713 0.09305383117838115 2.789897925867121e-11 10.554411685989342 -0.6469812270763791 HVFGESDELIGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVFGESDELIGQK 13 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3;U3KPS5 P60174 TPI1 Triosephosphate isomerase 0 61775400.0 6867400.0 24259000.0 30649000.0 False True 9003227.903996201 20639651.760841385 27477735.48596781 1.0 2.2924724311022056 3.051987107176467 23.102010909230735 -8.734895948544231 0.20190279768326488 8.401053096241687e-23 3.884738328751596 0.9996238122535275 0.016429714430197247 0.28724413711698193 0.05952674138932667 0.5724395694467919 0.3875644020239281 1.841213079955987e-09 8.734895948544231 3.884738328751596 HVFGESDELIGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVFGESDELIGQK 13 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3;U3KPS5 P60174 TPI1 Triosephosphate isomerase 0 40979600.0 9349700.0 8149900.0 23480000.0 False True 9052898.891267037 11404197.571167031 17329883.6150988 1.0 1.2597288126312993 1.9142910821434485 23.109948410843266 -6.9552893288231905 0.4974021369157074 0.9865907481120536 2.2155364195633123 0.9995536346612247 0.008127364395805428 0.08142883366535125 0.0276916221245929 0.00957851863691731 0.05399131431962074 1.1084361243896534e-07 6.9552893288231905 1.2289456714512585 HVFGESDELIGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVFGESDELIGQK 13 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3;U3KPS5 P60174 TPI1 Triosephosphate isomerase 0 112604300.0 5583200.0 100230000.0 6791100.0 False True 8470122.586594408 82343173.39943558 5448836.108355131 1.0 9.721603501909101 0.6433007376987623 23.01395141890432 -6.655306243980713 1.9897921303808284 6.6356422879708274 0.6815753464677446 0.2157408439226055 3.7176860197619197 0.49567903163907884 3.7676094764872206 1.512222193893008 4.11880601879916 2.211534689710448e-07 6.655306243980713 -5.954066941503083 HVFGESDELIGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVFGESDELIGQK 13 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3;U3KPS5 P60174 TPI1 Triosephosphate isomerase 0 45056400.0 6867400.0 13933000.0 24256000.0 False True 9406463.364506874 13317393.989730414 18527232.368000936 1.0 1.4157705689877598 1.9696278665060436 23.165220970753627 -6.967154466224894 0.3189177549338401 0.9231796193646417 2.480054810962646 0.9999509172451463 0.002782633799668394 0.07723725629305034 0.012320874843493793 0.008432516258222271 0.04876544852254996 1.0785630397304237e-07 6.967154466224894 1.5568751915980044 HVFGESDELIGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVFGESDELIGQK 13 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3;U3KPS5 P60174 TPI1 Triosephosphate isomerase 0 16306200.0 9349700.0 3622300.0 3334200.0 False True 7774689.811939416 3602785.9509297446 4031365.8044010154 1.0 0.4633993172817039 0.5185243272612803 22.890353686277543 -10.399890596037206 5.161558948603629 1.0004066776369431 0.4909618222714676 0.9912812378650586 0.02250469108605072 0.00010540047512217483 1.2254397741520566e-05 0.021806966226485935 0.007263357815639149 3.982074711336343e-11 10.399890596037206 -0.5094448553654756 HVFGESDELIGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVFGESDELIGQK 13 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3;U3KPS5 P60174 TPI1 Triosephosphate isomerase 0 20609000.0 5583200.0 7406800.0 7619000.0 False True 7227562.461325475 6994605.068899529 6232420.177541716 1.0 0.9677681938174183 0.8623128766982309 22.78507774099677 -6.9494866588710815 0.5644530961084593 1.0013484037212723 0.8236541290416727 0.9991603574173455 0.0017038271413599133 0.083692578165089 0.036820805958236 0.0018167360545192272 0.008774924018263993 1.1233454772890202e-07 6.9494866588710815 -0.17769427467959964 HVFGQAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVFGQAVK 8 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;F8W1H8;F8VUX3;F8VSA4;F8VRE9;F8VTT6;F8VVB7 Q9ULV4 CORO1C Coronin-1C;Coronin 0 8846600.0 2062300.0 3583300.0 3201000.0 False True 2703695.2713416093 3048685.607594003 2869791.2261601635 1.0 1.1275995634231386 1.06143294201056 21.366501126529208 -10.2695599414346 3.9214781541285038 0.999870851450337 1.0945162527288403 0.7312302607217005 0.02701241012609503 19118638.302601952 4.8511708624840155 22295.8709129277 0.009247066467128709 5.3757623159381304e-11 10.2695599414346 0.0946454012785033 HVFGQAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVFGQAVK 8 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;F8W1H8;F8VUX3;F8VSA4;F8VRE9;F8VTT6;F8VVB7 Q9ULV4 CORO1C Coronin-1C;Coronin 0 7245600.0 1881300.0 3492700.0 1871600.0 False True 2854069.6414529416 2869400.3964103446 1501677.439648577 1.0 1.0053715420025975 0.5261530475073157 21.444589107415005 -6.904365058683418 0.9332510462569723 1.017608917798741 0.4711416259404 0.9886158578053259 0.023969407991192175 0.10826346198082822 0.15984977636021913 0.01909297965156774 0.05085854647146574 1.2463354308119664e-07 6.904365058683418 -0.5464672918583411 HVFGQAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVFGQAVK 8 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;F8W1H8;F8VUX3;F8VSA4;F8VRE9;F8VTT6;F8VVB7 Q9ULV4 CORO1C Coronin-1C;Coronin 0 9826100.0 2062300.0 3942400.0 3821400.0 False True 2824788.041561949 3768211.732226593 2918864.024203449 1.0 1.333980347121189 1.0333037315569635 21.4297111880521 -9.735171311136458 6.573343066869002 0.9999999991091226 1.1836420393391582 0.33216446362538354 0.12275071428684965 1.6373016133602077e-09 2.694284639702304e-10 0.11885286804187802 0.039617622680626 1.8400460365542626e-10 9.735171311136458 0.1836420402300356 HVFGQPAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVFGQPAK 8 0 H3BNA2;H3BU76;H3BSL1;P31146;H3BRY3;H3BTU6;H3BRJ0 H3BNA2;P31146 CORO1A Coronin;Coronin-1A 0 48391700.0 8933700.0 22690000.0 16768000.0 False True 11712167.214073857 19304740.444927253 15033008.210013663 1.0 1.6482637322433225 1.2835377035899331 23.48150472038406 -10.061496804078397 4.3484434863675805 0.9999627818993566 1.4659007178339014 0.6851053008371343 0.14889877789426217 19341113.577486496 11187944.996255236 6552.135400191385 0.050972012748068354 8.679669645348637e-11 10.061496804078397 0.4659379359345448 HVFGQPAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVFGQPAK 8 0 H3BNA2;H3BU76;H3BSL1;P31146;H3BRY3;H3BTU6;H3BRJ0 H3BNA2;P31146 CORO1A Coronin;Coronin-1A 0 16571300.0 4469000.0 8068300.0 4034000.0 False True 6779799.727663423 6628448.827084372 3236678.1318349876 1.0 0.9776761989057732 0.47740025691739274 22.692811226730893 -6.916241724601851 0.8521295097442195 1.0126029487715302 0.40330891351998066 0.993071750536507 0.0200820669422786 0.10043407739235923 0.1174442271147643 0.016966808137667627 0.04913323061403048 1.2127136765027493e-07 6.916241724601851 -0.6092940352515496 down HVFGQPAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVFGQPAK 8 0 H3BNA2;H3BU76;H3BSL1;P31146;H3BRY3;H3BTU6;H3BRJ0 H3BNA2;P31146 CORO1A Coronin;Coronin-1A 0 43231700.0 8933700.0 17176000.0 17122000.0 False True 12236730.314164748 16417107.526563529 13078136.238658983 1.0 1.3416253447671183 1.068760682215923 23.54471478190695 -10.36411782391307 5.29723044321654 0.9999121586517861 1.2051930134912172 0.42987340830416576 0.11139653201454956 0.00011562606503515366 1.3879779753938258e-05 0.10790528308658427 0.035953076109797345 4.323965061276012e-11 10.36411782391307 0.20528085483943115 HVFGQPAK(ub)ADQCYEDVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVFGQPAKADQCYEDVR 17 1 H3BNA2;H3BU76;H3BSL1;P31146;H3BRY3;H3BTU6;H3BRJ0 H3BNA2;P31146 CORO1A Coronin;Coronin-1A 1 8963000.0 2829100.0 3691700.0 2442200.0 True False 3708977.4970433693 3140912.7501338935 2189504.5712366006 1.0 0.8468406057027006 0.5903256552464865 21.82259008413128 -6.963360585216772 0.38515395347174214 1.0166302578796218 0.41139028573105973 0.9998752593117375 0.0018876611617913038 0.0785217727164477 0.01684940115966429 0.003322725456774041 0.02162339067245935 1.0880263537051709e-07 6.963360585216772 -0.6052399721485621 HVFGQPAK(ub)ADQCYEDVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVFGQPAKADQCYEDVR 17 1 H3BNA2;H3BU76;H3BSL1;P31146;H3BRY3;H3BTU6;H3BRJ0 H3BNA2;P31146 CORO1A Coronin;Coronin-1A 1 48447700.0 5788200.0 9143500.0 33516000.0 True False 8781122.574101906 7511770.9865084365 26891547.909415357 1.0 0.8554454083880849 3.062427119366991 23.065973954251707 -6.891254079709037 1.0149576508363216 0.8849564513374617 3.2569617893189315 0.9816880951051838 0.13640923429727878 0.11813063106587979 0.21596263670793922 0.10223493646733475 0.25604567819369733 1.2845349355586125e-07 6.891254079709037 2.37200533798147 up HVFGQPAK(ub)ADQCYEDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVFGQPAKADQCYEDVR 17 1 H3BNA2;H3BU76;H3BSL1;P31146;H3BRY3;H3BTU6;H3BRJ0 H3BNA2;P31146 CORO1A Coronin;Coronin-1A 1 7828300.0 2829100.0 2285700.0 2713500.0 True False 3875094.7235527826 2184710.2162008765 2072627.1862867146 1.0 0.5637824032848106 0.5348584574434554 21.885800145654173 -13.999999999999998 0.3855868617622391 7.705755612668852 0.532562055731732 0.9998163685840318 0.0028833940903049615 24.75661672885651 0.2030723789055948 138.1187582353799 0.007710797049689263 1.0000000000000041e-14 13.999999999999998 -7.17319355693712 HVFGQPAK(ub)ADQCYEDVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVFGQPAKADQCYEDVR 17 1 H3BNA2;H3BU76;H3BSL1;P31146;H3BRY3;H3BTU6;H3BRJ0 H3BNA2;P31146 CORO1A Coronin;Coronin-1A 1 5582270.0 1404500.0 810570.0 3367200.0 True False 1167903.9798997734 806203.2985244516 4071265.951826251 1.0 0.6902992989146572 3.4859594811686807 20.155490236164667 -6.879409412364107 1.0830364251707485 0.8094896952725731 3.681896319303443 0.97320815823644 0.2048144376368208 0.12815691460469214 0.2754298524661923 0.14574804186004556 0.3519483783393473 1.320050626729559e-07 6.879409412364107 2.87240662403087 up HVFGQPAK(ub)ADQCYEDVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVFGQPAKADQCYEDVR 17 1 H3BNA2;H3BU76;H3BSL1;P31146;H3BRY3;H3BTU6;H3BRJ0 H3BNA2;P31146 CORO1A Coronin;Coronin-1A 1 44446900.0 5788200.0 5615700.0 33043000.0 True False 7492939.002479604 5303181.358402959 27029513.049811136 1.0 0.70775717734363 3.6073312542470157 22.837100276344156 -6.882078366381897 1.0680995530393997 0.8133550071642858 3.8212253432282193 0.9753252731965257 0.2047502570737249 0.12580678868657333 0.2612745294866088 0.14737638665955408 0.3583647433386485 1.3119631401252993e-07 6.882078366381897 3.0078703360639336 up HVFLTGPPGVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVFLTGPPGVGK 12 0 Q5TDF0;Q9BSD7 Q5TDF0 NTPCR Cancer-related nucleoside-triphosphatase 0 5851500.0 1881000.0 2409200.0 1561300.0 False True 2466009.2156299124 2049756.7509880452 1399751.6530471316 1.0 0.8312040109162607 0.5676181760292335 21.233746760516155 -6.964580527835864 0.36518681670893627 1.0214089309196779 0.3683072752120447 0.9999042258611538 0.0017412643672425315 0.07810367176813404 0.015364092251856351 0.0035018092104744385 0.022445663706712443 1.0849743526547941e-07 6.964580527835864 -0.6531016557076332 HVFLTGPPGVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVFLTGPPGVGK 12 0 Q5TDF0;Q9BSD7 Q5TDF0 NTPCR Cancer-related nucleoside-triphosphatase 0 4684400.0 1276300.0 1647300.0 1760800.0 False True 1235784.5551112976 2305075.4805560145 1299593.6571322817 1.0 1.8652729320997332 1.051634487384605 20.236995817125518 -10.268650509568108 4.22259423410329 0.9996258004061043 1.4584537097568866 0.2974163481952413 0.33216650415994287 235077463.7529219 538.9595192825976 855282.5559486535 0.11370942947772757 5.387031194800612e-11 10.268650509568108 0.4588279093507823 HVFLTGPPGVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVFLTGPPGVGK 12 0 Q5TDF0;Q9BSD7 Q5TDF0 NTPCR Cancer-related nucleoside-triphosphatase 0 6631400.0 1881000.0 1915700.0 2834700.0 False True 2576456.5321136727 1831058.0396272528 2165202.2424790673 1.0 0.710688504465119 0.8403798843455664 21.296956822039046 -10.029787316679563 4.549224610411012 1.000008366083822 0.7755341944026948 0.7997629677991118 0.05294628417783368 36598981.18436125 1.5422405743632104 3319.3811008071975 0.01812492135464927 9.337114473681212e-11 10.029787316679563 -0.22447417168112715 HVFLTGPPGVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVFLTGPPGVGK 12 0 Q5TDF0;Q9BSD7 Q5TDF0 NTPCR Cancer-related nucleoside-triphosphatase 0 3808460.0 1276300.0 1646800.0 885360.0 False True 1061299.999676809 1637928.361535793 1070484.68255788 1.0 1.5433226816494685 1.0086541815545726 20.017401092559794 -10.676565947175533 3.0397072948070702 0.9713624362575031 1.2759884315833954 0.2621364048485697 0.21827750382843888 98469771.00980674 100766504.20831765 21901601.61544826 0.07988137808043466 2.1058820986555366e-11 10.676565947175533 0.3046259953258923 HVFSWTLQQVTRPWLSQHLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVFSWTLQQVTRPWLSQHLER 21 1 E5RIH5;Q6NXR4 E5RIH5 TTI2 TELO2-interacting protein 2 0 45054000.0 16941000.0 14257000.0 13856000.0 False True 25700735.552997548 11712726.959550563 11117355.526699455 1.0 0.4557350872467335 0.4325695466487459 24.615306314038328 HVFSWTLQQVTRPWLSQHLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVFSWTLQQVTRPWLSQHLER 21 1 E5RIH5;Q6NXR4 E5RIH5 TTI2 TELO2-interacting protein 2 0 54658000.0 16941000.0 20776000.0 16941000.0 False True 21930458.45703448 19619797.336428203 13857911.829339046 1.0 0.8946368984883167 0.6319025138707914 24.386432636130777 -6.955516579594029 0.4945904404932443 1.0055176539312647 0.5097935347252313 0.9995660884904924 0.0032242573638978605 0.08134332196001193 0.02735848703530381 0.0038208312486151083 0.02167031063086992 1.1078562711278922e-07 6.955516579594029 -0.49572411920603343 HVFTTFYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVFTTFYAK 9 0 Q9BUB7;Q9BUB7-2 Q9BUB7 TMEM70 Transmembrane protein 70, mitochondrial 0 4266700.0 1866900.0 0.0 2399800.0 False True 2447523.979085319 0.0 2151491.7165070805 1.0 0.0 0.8790482687369335 21.22289156371413 -9.091924218608485 11.770053321355729 0.9999844904702884 0.4395241348444452 0.351506179684282 0.3588699530588181 0.0 0.0 0.34747433786226756 0.11582477928742249 8.092370931503217e-10 9.091924218608485 -0.5604603556258432 HVFTTFYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVFTTFYAK 9 0 Q9BUB7;Q9BUB7-2 Q9BUB7 TMEM70 Transmembrane protein 70, mitochondrial 0 4122500.0 1866900.0 870500.0 1385100.0 False True 2557143.381075501 832038.4316414492 1057967.9070299366 1.0 0.32537809095847603 0.4137303816671278 21.28610162523702 -10.710628224372622 6.863741227946875 1.0065084071937616 0.3695542363159278 0.9854838663041678 0.03606967164037333 0.003591399343591281 0.0001514113293366358 0.03491498252765859 0.011641436463861319 1.9470261104239434e-11 10.710628224372622 -0.6369541708778337 HVFWGSGSHTLPALLENLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVFWGSGSHTLPALLENLK 19 0 P02786;G3V0E5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 0 6829500.0 2812100.0 4017400.0 0.0 False True 2722831.424765716 5621568.770464239 0.0 1.0 2.0646040439128335 0.0 21.376676234708853 -6.771687312813342 1.6017847725434273 1.6130480275533219 9.126946913923066e-11 0.716980432362712 0.44847706799928344 0.268297264419647 1.3642474068906385 0.22190035518850593 0.5202573093054872 1.6916584685275888e-07 6.771687312813342 -1.6130480274620524 HVFWGSGSHTLPALLENLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVFWGSGSHTLPALLENLK 19 0 P02786;G3V0E5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 0 9135600.0 2812100.0 3696600.0 2626900.0 False True 2338385.74715283 3676685.682082349 3176172.6445867135 1.0 1.57231786353428 1.3582757457592083 21.15708151014313 -10.089700746947095 4.549781328238676 0.9999703052147656 1.465296804591348 0.8630299886813834 0.08738232875672977 10267849.774062917 22770223.694965854 2009.4277720492025 0.02991329718821005 8.133907946076105e-11 10.089700746947095 0.4653264993765823 HVGDLGNVTADK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVGDLGNVTADK 12 0 P00441;H7BYH4 P00441 SOD1 Superoxide dismutase [Cu-Zn] 0 11654930.0 960330.0 4898800.0 5795800.0 False True 1259001.9298489501 4167918.1353728436 5196106.213239325 1.0 3.3104938416360437 4.127163024970686 20.26384906380396 -9.391579448165123 0.32533248046089486 4.0521510257441443e-22 4.389302494944643 0.998507832131917 0.051156722135889364 0.7712878376084619 0.12807210973453978 1.1398891126236654 0.25910486923021947 4.0590140241510775e-10 9.391579448165123 4.389302494944643 HVGDLGNVTADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVGDLGNVTADK 12 0 P00441;H7BYH4 P00441 SOD1 Superoxide dismutase [Cu-Zn] 0 6882920.0 1514100.0 992720.0 4376100.0 False True 1466035.7242764395 1389118.2729664098 3229868.1298140516 1.0 0.9475337128309119 2.203130576103901 20.483488828736213 -6.8971487345251505 0.9791275016496203 0.9436349191499792 2.3275494717309573 0.9850932745683668 0.07080463494056323 0.11353423759016805 0.18949701510826836 0.054514016030355036 0.1399106097708556 1.2672178025108903e-07 6.8971487345251505 1.3839145525809782 up HVGDLGNVTADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVGDLGNVTADK 12 0 P00441;H7BYH4 P00441 SOD1 Superoxide dismutase [Cu-Zn] 0 9883730.0 960330.0 4724600.0 4198800.0 False True 1315389.9529424375 4515851.549837101 3207129.9170004306 1.0 3.4330895866548543 2.4381590492053706 20.32705912532685 -10.502034833680977 6.359916453752929 0.9986823374163665 2.9356243179301122 0.83461668002981 0.4061786910440443 0.007591147883122379 0.0005943680264686351 0.3934011825878181 0.13109360883315924 3.147495851157457e-11 10.502034833680977 1.9369419805137458 HVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVGDLGNVTADKDGVADVSIEDSVISLSGDHCIIGR 36 1 P00441;H7BYH4 P00441 SOD1 Superoxide dismutase [Cu-Zn] 0 89199700.0 11313000.0 69118000.0 8768700.0 False True 17162648.09108446 56783352.87860113 7035562.601542256 1.0 3.308542631489284 0.40993456045964394 24.032768833198705 -6.694568396625154 1.8503493344610917 2.4411120724959914 0.4194375496259021 0.3917444161180148 0.9754724963075442 0.40696375763121406 2.704927235439921 0.4212074208242779 1.0905121769935282 2.0203732202774057e-07 6.694568396625154 -2.0216745228700894 HVGMAVAGLLADAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVGMAVAGLLADAR 14 0 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 0 19400400.0 4749900.0 5185100.0 9465400.0 False True 6227164.898097038 4411503.291361501 8486011.206528092 1.0 0.7084288538287487 1.3627407247753043 22.57014405225174 -6.785561700139439 1.5139066740032208 0.836091319368826 1.3688831247847515 0.7866324420214346 0.12363118589913229 0.2420475805386472 1.0959357763688014 0.06429455117607828 0.1510374767437037 1.6384692677124713e-07 6.785561700139439 0.5327918054159255 HVGMAVAGLLADAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVGMAVAGLLADAR 14 0 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 0 17335700.0 5623500.0 3149000.0 8563200.0 False True 5444985.070648274 4406412.121818066 6320241.029506559 1.0 0.8092606434444167 1.1607453367643628 22.37649666261324 -6.759339221686389 1.6150414702702225 0.8891166354710188 1.1619839835156283 0.6882353697420963 0.08021778564774404 0.2840273528971662 1.4599994073548532 0.039192887968231394 0.0942450841855023 1.7404469022345217e-07 6.759339221686389 0.27286734804460944 HVGMAVAGLLADAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVGMAVAGLLADAR 14 0 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 0 20182700.0 4267100.0 12205000.0 3710600.0 False True 6473502.666796291 10026922.391899742 2977198.2835862455 1.0 1.5489176274429532 0.45990531507105226 22.62611510266439 -6.769675568484939 1.575798050947131 1.3149743704755124 0.45386944511918315 0.7292898017569627 0.23132055420300637 0.2669501698888995 1.3081733668819695 0.11571422565348631 0.27551844596603925 1.6995127673800414e-07 6.769675568484939 -0.8611049253563292 down HVGMAVAGLLADAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVGMAVAGLLADAR 14 0 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 0 17342700.0 4749900.0 7373300.0 5219500.0 False True 6506066.391221022 7047523.225757488 3986761.5989767923 1.0 1.083223379839327 0.6127760399673049 22.633354113774633 -6.8612076976475445 1.1796984183468897 1.0453020306379945 0.5894721879573871 0.9550872923033366 0.04344281281104182 0.14555790447520825 0.38425201091387234 0.028708857177690995 0.0671051217308767 1.376550987631056e-07 6.8612076976475445 -0.45582984268060744 HVGMAVAGLLADAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVGMAVAGLLADAR 14 0 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 0 10414000.0 5623500.0 2416400.0 2374100.0 False True 4676189.413290405 2403382.3735821517 2870513.3334018546 1.0 0.5139617242089023 0.613857369687259 22.156901938047515 -9.991939131553817 6.000219799869595 1.0000003899328256 0.5639095469480657 0.9621350603165088 0.04078222649152205 2.127333275551327e-07 3.5695353075761816e-08 0.03948725630881164 0.013162407001881208 1.0187341585075216e-10 9.991939131553817 -0.43609084298475986 HVGMAVAGLLADAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVGMAVAGLLADAR 14 0 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 0 18954500.0 4267100.0 10398000.0 4289400.0 False True 5523845.067115988 9819342.159423405 3508773.2129606884 1.0 1.7776280905992365 0.6352048564592756 22.39724142475684 -6.723448475076456 1.7471616261572358 1.4713525612765688 0.6366611645759984 0.5286461564760004 0.3270973901882029 0.3486495530407242 2.0817841912004225 0.14855627314102016 0.37139186657887635 1.8903904947962123e-07 6.723448475076456 -0.8346913967005704 HVGNQQYNVTYVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVGNQQYNVTYVVK 14 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;A0A0A0MT44 O75369-2 FLNB Filamin-B 0 18426100.0 4931600.0 6215500.0 7279000.0 False True 6465375.357682341 5288171.627829243 6525838.905098364 1.0 0.8179218274691027 1.009351900558129 22.624302699753667 -13.484592270241166 15.367537917117225 9.17370423850559 0.9222731776122748 0.0 0.09039426085225531 0.0 0.0 0.0 0.026162270212194572 3.276481572554427e-14 13.484592270241166 -8.251431060893314 HVGNQQYNVTYVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVGNQQYNVTYVVK 14 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;A0A0A0MT44 O75369-2 FLNB Filamin-B 0 14988100.0 4931600.0 4929700.0 5126800.0 False True 6754945.791478892 4711889.553662097 3915955.429760359 1.0 0.6975466123808081 0.5797167809548063 22.687512761276558 -13.999999999999998 0.13038210220705068 2.437408483747783 0.41550217429389463 0.9996438893404177 0.0033403737698790557 11.936129612079535 0.11232612253518032 4.395336295464562 0.14606172467480263 1.0000000000000041e-14 13.999999999999998 -2.0219063094538887 HVGPGVLSMANAGPNTNGSQFFICTIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVGPGVLSMANAGPNTNGSQFFICTIK 27 0 P30405;H0Y548 P30405 PPIF Peptidyl-prolyl cis-trans isomerase F, mitochondrial;Peptidyl-prolyl cis-trans isomerase 0 9497000.0 2089900.0 5295900.0 2111200.0 False True 2739879.138620388 4505772.363256514 1892753.2760604008 1.0 1.6445150078865545 0.6908163390789052 21.385680823838896 -6.724694196523992 1.7426906554459292 1.3901417203023765 0.6919217346550876 0.534464651300872 0.2710697712352387 0.3462688759171584 2.0576333873024124 0.1233962833513965 0.30804257191852613 1.8849759064583972e-07 6.724694196523992 -0.6982199856472889 HVGPGVLSMANAGPNTNGSQFFICTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVGPGVLSMANAGPNTNGSQFFICTIK 27 0 P30405;H0Y548 P30405 PPIF Peptidyl-prolyl cis-trans isomerase F, mitochondrial;Peptidyl-prolyl cis-trans isomerase 0 12066300.0 5632900.0 3161200.0 3272200.0 False True 5454086.672793577 4423483.645440216 2415112.65610419 1.0 0.8110402182469375 0.44280789818603516 22.37890619612959 -6.9605495358861 0.4276185589307368 1.0150016133424717 0.2247807570788415 0.999790039944912 0.003352459638225063 0.07950540138060322 0.020410290390733776 0.004791130831313037 0.030591964398278316 1.0950916414410878e-07 6.9605495358861 -0.7902208562636303 down HVGPGVLSMANAGPNTNGSQFFICTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVGPGVLSMANAGPNTNGSQFFICTIK 27 0 P30405;H0Y548 P30405 PPIF Peptidyl-prolyl cis-trans isomerase F, mitochondrial;Peptidyl-prolyl cis-trans isomerase 0 20697300.0 2089900.0 7890400.0 10717000.0 False True 2862592.5074239024 7541776.037936463 8185865.3235433055 1.0 2.6345964430415703 2.8595985290654973 21.448890885361788 -10.354602444180047 0.4207956005346229 5.337899890381257e-24 2.873477757316028 0.9992594703795601 0.022551041687306303 1.7497406218842768 0.19644770819039417 2.0172087316564826 0.05421542514793728 4.419748487039484e-11 10.354602444180047 2.873477757316028 HVILGTQQFKPNEFASQINLSVENAWGILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVILGTQQFKPNEFASQINLSVENAWGILR 30 1 O15371-2;O15371-3;O15371 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 0 155166600.0 42659000.0 45588000.0 66919600.0 False True 64716821.79064544 37452465.21933027 53692911.72809731 1.0 0.5787129865630064 0.8296592793414711 25.947637423718287 -10.273898361545559 5.746622740430854 1.000019878625017 0.704186132952236 0.6494596846959622 0.1024483950250626 2.6093647084260763e-05 3.2969249778943258e-06 0.09920189165155947 0.033065077314810676 5.322328037690378e-11 10.273898361545559 -0.295833745672781 HVILGTQQFKPNEFASQINLSVENAWGILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVILGTQQFKPNEFASQINLSVENAWGILR 30 1 O15371-2;O15371-3;O15371 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 0 73595000.0 42659000.0 17450000.0 13486000.0 False True 55222916.43460455 16478892.160217207 11031686.378045358 1.0 0.29840677066977533 0.19976645730236242 25.718763745810737 -13.999999999999998 0.27637781678458867 6.6054399243625905 0.16899597520272494 0.9995971927022915 0.0071503011342344755 15.205757225435216 0.1664873787426883 48.0736374929087 0.03970272678962259 1.0000000000000041e-14 13.999999999999998 -6.436443949159866 HVINFDLPSDIEEYVHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVINFDLPSDIEEYVHR 17 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 25322600.0 8210500.0 7017100.0 10095000.0 False True 7949862.171700484 9819064.623693088 7450816.656491592 1.0 1.2351238815996706 0.9372258909109935 22.922498417654765 -6.696276421741367 1.8439462924494971 1.146529548708654 0.938165226049924 0.4000294560919122 0.09931759726882979 0.403313434899084 2.6633087757591096 0.04301081432524358 0.11113204565846396 2.0124429532328909e-07 6.696276421741367 -0.20836432265872995 HVINFDLPSDIEEYVHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVINFDLPSDIEEYVHR 17 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 51678900.0 9543700.0 34227000.0 7908200.0 False True 14478490.637928272 28118924.43322839 6345140.803712812 1.0 1.942117112647588 0.43824601350992337 23.787407875563936 -6.737298654517014 1.6963068943573798 1.5622801172057061 0.4378197145248802 0.5929273524536015 0.3958699789648058 0.32269914183561377 1.822095371810427 0.1846906149628317 0.4546140163009861 1.831054814233789e-07 6.737298654517014 -1.124460402680826 HVINFDLPSDIEEYVHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVINFDLPSDIEEYVHR 17 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 17720100.0 8210500.0 5308000.0 4201600.0 False True 6827394.536822421 5279404.750444497 5080135.133996547 1.0 0.7732678581808774 0.7440810848996173 22.70290369308904 -13.999999999999998 0.28901834603560617 2.9429793940618865 0.7360486331549083 0.9996252636039552 0.002214255414214869 15.907746842055678 0.1704651004353699 18.36667784880031 0.011072275558546854 1.0000000000000041e-14 13.999999999999998 -2.206930760906978 HVIPMNPNTNDLFNAVGDGIVLCK ddPTM_RPMI8226_Bortezomib_1h_R1 2 HVIPMNPNTNDLFNAVGDGIVLCK 24 0 P13796;Q5TBN3 P13796 LCP1 Plastin-2 0 23794100.0 7931100.0 12248000.0 3615000.0 False True 10397748.904881652 10420646.14233007 3240954.477528587 1.0 1.0022021341020908 0.3116977056454005 23.30976788533818 -6.906180607680981 0.9213515364179993 1.024046635486109 0.2293842753440867 0.9893986647308025 0.03346178309610833 0.10699822809072353 0.15286818151850015 0.02688843265920802 0.07239963782785919 1.241136055762265e-07 6.906180607680981 -0.7946623601420224 down HVIPMNPNTNDLFNAVGDGIVLCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVIPMNPNTNDLFNAVGDGIVLCK 24 0 P13796;Q5TBN3 P13796 LCP1 Plastin-2 0 23687000.0 16639000.0 3772000.0 3276000.0 False True 16110804.052728122 5278179.270720139 2417917.322106634 1.0 0.32761737114085 0.15008048724279505 23.94152516160403 -13.999999999998538 0.18692861192118662 4.566962325869874 0.01870150514958869 0.9994913945796573 0.008255423364673655 12.302309411940834 0.1371010529308005 15.967644139690497 0.12514403226906498 1.0000000000033662e-14 13.999999999998538 -4.5482608207202855 HVIPMNPNTNDLFNAVGDGIVLCK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 HVIPMNPNTNDLFNAVGDGIVLCK 24 0 P13796;Q5TBN3 P13796 LCP1 Plastin-2 0 27139800.0 7931100.0 4681100.0 14527600.0 False True 10863441.999918522 4474273.523672362 11096480.085313765 1.0 0.41186518266548666 1.0214515883084745 23.37297794686107 -10.95971954310771 12.40026460789085 1.089706113252103 0.716658385486992 0.22364103388967693 0.24886260799376073 0.10782102670375553 0.00035024050926646947 0.04209536222955114 0.080320061354465 1.0971865039720626e-11 10.95971954310771 -0.3730477277651111 HVISYSLSPFEQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVISYSLSPFEQR 13 0 O14949 O14949 UQCRQ Cytochrome b-c1 complex subunit 8 0 20966000.0 7818400.0 10138000.0 3009600.0 False True 10249998.113493312 8625449.917614486 2698195.462121726 1.0 0.8415074639145311 0.2632386301193329 23.28912030841503 -6.94698971757367 0.5909724212943689 1.0066648542706809 0.06893507729265834 0.998943348860142 0.010292661266045933 0.08471759229365772 0.041142565739552744 0.010660111681948456 0.048458660354709145 1.129822664220096e-07 6.94698971757367 -0.9377297769780225 down HVISYSLSPFEQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVISYSLSPFEQR 13 0 O14949 O14949 UQCRQ Cytochrome b-c1 complex subunit 8 0 20999600.0 7818400.0 7993400.0 5187800.0 False True 10709073.764315551 7640225.15736101 3962548.486094791 1.0 0.7134347307252225 0.37001785339257576 23.35233036993792 -6.968719104407815 0.2871380771418769 1.0694401957743307 0.003444404213022874 0.9999705950805874 0.0013965213323788388 0.07672057041228846 0.010510589417470007 0.006093650547920038 0.03124717234690595 1.07468427835137e-07 6.968719104407815 -1.0659957915613079 down HVK(ub)DEQIEHWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVKDEQIEHWK 11 1 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 1 12528800.0 4603500.0 4608700.0 3316600.0 True False 6035233.0803574165 3921099.924571897 2973430.0470736707 1.0 0.649701489961293 0.492678577195494 22.5249780581806 -13.999999999999998 0.10846354392035734 2.6949893669975364 0.19814822368060842 0.9997508711679229 0.003347174101022863 12.021872096913622 0.09968276363882148 4.475436662360397 0.2617138057248187 1.0000000000000041e-14 13.999999999999998 -2.496841143316928 HVK(ub)DEQIEHWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVKDEQIEHWK 11 1 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 1 15587300.0 4080900.0 6057100.0 5449300.0 True False 3951354.063271725 8475731.617359217 4021964.85450417 1.0 2.1450195253677933 1.017870023820133 21.913915694920977 -6.64256921445889 2.0357613735746303 1.7473294764455034 1.0226267444927741 0.16437669091098395 0.4896096245959993 0.5268693281951574 4.176501255477153 0.19566943750558974 0.541985747162293 2.2773552658577304e-07 6.64256921445889 -0.7247027319527293 HVK(ub)DEQIEHWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVKDEQIEHWK 11 1 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 1 25345300.0 12891000.0 8081800.0 4372500.0 True False 19556589.45833726 6639539.646608386 3508273.4584651687 1.0 0.33950396416272133 0.17939086290782366 24.221151459830978 -13.999999999999703 0.19904714697235265 4.658383410984996 0.07442439901324148 0.9994869144678691 0.008045018256026815 12.512214783542312 0.14146966085295 17.813977151989523 0.10268072270821052 1.000000000000683e-14 13.999999999999703 -4.583959011971754 HVK(ub)DEQIEHWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVKDEQIEHWK 11 1 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 1 12829300.0 4603500.0 3400100.0 4825700.0 True False 6305538.354909777 3249872.3393728794 3685969.0484112035 1.0 0.5153996624003376 0.584560562626844 22.588188119703492 -10.571301187721819 6.3905623043043525 1.0008196062039365 0.5499801125136693 0.9825942255760413 0.028234819284413012 0.00033026155947885933 2.215495309069538e-05 0.02738404030612824 0.009112748739308965 2.683482777087265e-11 10.571301187721819 -0.4508394936902672 HVK(ub)DEQIEHWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVKDEQIEHWK 11 1 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 1 18551000.0 4080900.0 8685800.0 5784300.0 True False 3393449.1645233072 8639007.871403696 6993770.386418571 1.0 2.545789682580159 2.0609621795825595 21.694320970355253 -10.17384659590259 6.391824188714264 0.9999931699098584 2.3033759310813613 0.9059810335627526 0.19792999926864022 1.9265312171864075e-05 2.490817890867707e-06 0.19164590097459755 0.06388163257352315 6.70121271864669e-11 10.17384659590259 1.3033827611715028 HVK(ub)DEQIEHWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVKDEQIEHWK 11 1 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 1 30928200.0 12891000.0 8965400.0 9071800.0 True False 16687653.61959929 8466467.608780008 7420825.484528553 1.0 0.5073491937078753 0.44468956832930384 23.992277781923427 -13.999999999999998 0.2907463957584522 5.263064116859504 0.4277426558027432 0.9996291327069646 0.004782274158969498 16.010135409204132 0.17100870160254925 40.841083121323884 0.023585326675953464 1.0000000000000041e-14 13.999999999999998 -4.835321461056761 HVLDNSGEWSVTK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVLDNSGEWSVTKR 14 1 K7ESP4;Q8WVC6 K7ESP4 DCAKD Dephospho-CoA kinase domain-containing protein 1 6734500.0 1682400.0 1726500.0 3325600.0 True False 2205642.6923847743 1468912.9298442912 2981498.813407764 1.0 0.6659795509562251 1.3517596588521426 21.072767666837375 -6.774267525374673 1.558168606742185 0.8094607491769639 1.3562501807062373 0.746596178213206 0.14094973540140604 0.25958485372736245 1.2443531397071217 0.07127828589930886 0.1690130418874468 1.6816378531350604e-07 6.774267525374673 0.5467894315292734 HVLDNSGEWSVTK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVLDNSGEWSVTKR 14 1 K7ESP4;Q8WVC6 K7ESP4 DCAKD Dephospho-CoA kinase domain-containing protein 1 29213400.0 3622400.0 10542000.0 15049000.0 True False 5495445.632912959 8660697.734978054 12074558.553788979 1.0 1.5759773298652937 2.197193705542792 22.389805045280404 -6.970160668360221 0.2543211434696601 0.8130444285618088 2.9784219992578174 0.9999836082758226 0.001979258875364306 0.07625062227550089 0.008843501783003992 0.01345952554157905 0.0591264475638944 1.071122967233237e-07 6.970160668360221 2.1653775706960086 HVLDNSGEWSVTK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVLDNSGEWSVTKR 14 1 K7ESP4;Q8WVC6 K7ESP4 DCAKD Dephospho-CoA kinase domain-containing protein 1 6550500.0 1682400.0 1423000.0 3445100.0 True False 2304428.745150472 1360127.1547682742 2631438.3340616785 1.0 0.5902231334470973 1.1419048384982082 21.135977728360267 -6.707798403418349 1.8030574542343254 0.7475123116240142 1.1405257750499236 0.4546225336098457 0.17273858058860855 0.3795259836791151 2.403777969924626 0.07627923040483384 0.19430387889577178 1.959754167121342e-07 6.707798403418349 0.39301346342590937 HVLDNSGEWSVTK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVLDNSGEWSVTKR 14 1 K7ESP4;Q8WVC6 K7ESP4 DCAKD Dephospho-CoA kinase domain-containing protein 1 24060000.0 3622400.0 10895000.0 9542600.0 True False 4689268.208179081 10288683.672525302 7805944.715344484 1.0 2.1940915332118665 1.6646402740899435 22.160931367372854 -10.123557034627167 4.489730324006039 0.9998951344606767 1.9293659036680313 0.8042394641537157 0.21614757153867317 33202176.906787254 37432595.39962965 28896.396706019546 0.07399306677884451 7.52389914512916e-11 10.123557034627167 0.9294707692073546 HVLDTLIQLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVLDTLIQLAK 11 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 9829100.0 1667300.0 2628300.0 5533500.0 False True 2185846.446156168 2236167.885033159 4960946.501080059 1.0 1.023021488524723 2.269576854222277 21.05976062580059 -6.910900518181393 0.8895655302431942 0.962494356591323 2.4338231440499194 0.9912572690742868 0.055459415549485254 0.10382603636177495 0.13555427404542553 0.04560843326768212 0.12670184340823368 1.2277204271635265e-07 6.910900518181393 1.4713287874585963 up HVLDTLIQLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVLDTLIQLAK 11 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 7002000.0 2114700.0 1391800.0 3495500.0 False True 2047570.0060282557 1947552.9981411186 2579923.687247778 1.0 0.9511533146155312 1.2599929084974963 20.965481347502173 -6.86643596370095 1.152716366519209 0.9728859571423306 1.276900980946093 0.9609984359252051 0.02676951496560602 0.14032157701591005 0.3507080038737478 0.018058504017872866 0.0425110007590862 1.3600786907807826e-07 6.86643596370095 0.30401502380376233 HVLDTLIQLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVLDTLIQLAK 11 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 11267800.0 1667300.0 3355000.0 6245500.0 False True 2283745.8670883174 3206765.0064986343 4770441.530110072 1.0 1.4041689369698251 2.0888670665410727 21.12297068732348 -6.963156502418444 0.3883944358404698 0.957188739696475 2.5603859980123436 0.9998699556959032 0.005125032866226192 0.07859222785951069 0.017101233475190374 0.00884873332978886 0.05763525300968433 1.0885377570326292e-07 6.963156502418444 1.6031972583158685 up HVLDTLIQLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVLDTLIQLAK 11 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 5648100.0 2114700.0 1109900.0 2423500.0 False True 1758466.7470943737 1103920.7484020994 2930242.64500206 1.0 0.6277745941037428 1.66636227261271 20.74588662293645 -6.809777843101363 1.415406340149899 0.7970864883476553 1.6844501845039894 0.8592606792338592 0.16117756650716134 0.20710420842954172 0.8177803473771611 0.08953932550330113 0.20714962514501947 1.5496090957468617e-07 6.809777843101363 0.8873636961563341 HVLDTLIQLAK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVLDTLIQLAK 11 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 72834300.0 16587400.0 22601400.0 33645500.0 True False 21746242.03261011 19229359.219567165 30164186.41042543 1.0 0.8842612526215475 1.3870988083914444 24.37426277462837 -6.846139518815535 1.253570807024757 0.9383858961356941 1.4057530574338946 0.9345018277249284 0.05502818310535379 0.16175102951371192 0.49107878029578617 0.03438117132971025 0.07938854001317748 1.4251496850953393e-07 6.846139518815535 0.46736716129820044 HVLDTLIQLAK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVLDTLIQLAK 11 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 69006700.0 28201700.0 13946900.0 26858100.0 True False 27306452.47033012 19515969.902122676 19823157.884271074 1.0 0.7147017696029095 0.7259514177394506 24.702738562133792 -9.946611341103296 5.5503101492545985 1.0000003981231138 0.7203265936748163 0.9987879771995277 0.004592649621854643 2.262698975438624e-08 4.2978925844459716e-09 0.004446820235427815 0.0014822712914405974 1.1308074443898354e-10 9.946611341103296 -0.2796738044482975 HVLDTLIQLAK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVLDTLIQLAK 11 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 15194200.0 4606200.0 4073200.0 6514800.0 True False 6987942.158326986 3346305.63594314 5227146.924461729 1.0 0.47886853670584667 0.7480237823996504 22.73643623593028 -10.415930452655607 5.026394412278877 1.0004481734067312 0.6134461595527159 0.7333424872832809 0.10988216892398994 0.0005524882231448128 6.419936570314675e-05 0.10651340923185479 0.03546431752396399 3.837686967837194e-11 10.415930452655607 -0.38700201385401534 HVLDTLIQLAK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVLDTLIQLAK 11 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 50916500.0 16587400.0 17968400.0 16360700.0 True False 22720210.037630167 17174496.67444714 12496639.619193317 1.0 0.755912759873347 0.5500230675022747 24.43747283615126 -6.9730932648078925 0.16866129299829646 1.1852205365180783 0.11520859672883309 0.9999975490873818 0.00028788045195519545 0.07531122443664319 0.0052534391964414754 0.00878442983337239 0.023961841193627112 1.0639145178808895e-07 6.9730932648078925 -1.0700119397892454 HVLDTLIQLAK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVLDTLIQLAK 11 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 61505300.0 28201700.0 14950200.0 18353400.0 True False 23450963.097144485 14869660.305217637 22191011.08346638 1.0 0.6340746110776255 0.9462729096259794 24.48314383756807 -10.101275916215917 7.1658925977336585 1.0000000761551953 0.7901737603518024 0.37588872319244615 0.1274544216680923 1.551044775763028e-07 1.9374817993686658e-08 0.12340725818338484 0.04113573771008491 7.919979979925553e-11 10.101275916215917 -0.20982631580339284 HVLDTLIQLAK(ub)VFPSHFTQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVLDTLIQLAKVFPSHFTQQR 21 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 101938000.0 36931000.0 33549000.0 31458000.0 True False 56027027.01775294 27561918.830466624 25240312.511468768 1.0 0.49193969941923293 0.45050244239215165 25.73961960456583 -13.999999999999998 0.3551851730255388 7.451597785882525 0.4451643838717133 0.9997644624047701 0.0038343815623694435 21.18734466941479 0.19223500413280725 103.38544884896064 0.012148996698063705 1.0000000000000041e-14 13.999999999999998 -7.006433402010812 HVLDTLIQLAK(ub)VFPSHFTQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVLDTLIQLAKVFPSHFTQQR 21 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 105831400.0 36931000.0 62701000.0 6199400.0 True False 47807907.518844254 59211634.23139131 5071172.811215669 1.0 1.2385322283359106 0.10607393367335277 25.51074592665828 -6.851673242842701 1.2268254013165987 1.1275057321215503 0.059278518186785444 0.942726072983818 0.11665627877656747 0.1556256875643205 0.44987523763304693 0.07436877605665315 0.17230522756507355 1.40710581289755e-07 6.851673242842701 -1.0682272139347648 down HVLESEK(ub)NQLLQQVDHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVLESEKNQLLQQVDHLK 18 1 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 54078900.0 6050200.0 8409700.0 39619000.0 True False 5858139.7127120495 11767737.066006148 29241595.355476968 1.0 2.008783955847005 4.99161795203062 22.48201117026307 -6.951775838467146 0.5389954671725989 0.9557924877994864 6.182119933088875 0.9993333764988843 0.04375545132737326 0.08278039813604246 0.033071136052728746 0.04819269382193949 0.2469817044103832 1.1174398666656096e-07 6.951775838467146 5.226327445289388 HVLESEK(ub)NQLLQQVDHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVLESEKNQLLQQVDHLK 18 1 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 24699900.0 8912800.0 9502000.0 6285100.0 True False 13521369.212960077 7806293.860535137 5042847.2301428085 1.0 0.5773301311122319 0.3729538888198761 23.688737914702113 -12.012513806026064 0.11814257674597423 2.3164459015388723 3.402613597886029e-15 0.9997726551662365 0.003937002815523001 5.560950486660024 0.08400334570966667 2.1024904030561253 0.28087133082106946 9.71597064452891e-13 12.012513806026064 -2.3164459015388688 HVLESEK(ub)NQLLQQVDHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVLESEKNQLLQQVDHLK 18 1 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 50507400.0 3489400.0 16334000.0 30684000.0 True False 4779525.477489339 15612309.870685173 23437071.156816483 1.0 3.266497886498607 4.903639758214629 22.188435960489254 -7.9972227772279965 0.24305395321997328 8.009969025240977e-22 6.461642963730392 0.9996289300893374 0.03083154502024415 0.10558990029511528 0.04566708780358359 0.38876355567733467 0.5467468485721882 1.0064152820893878e-08 7.9972227772279965 6.461642963730392 HVLESEK(ub)NQLLQQVDHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVLESEKNQLLQQVDHLK 18 1 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 34940200.0 6050200.0 13160000.0 15730000.0 True False 5031009.369305526 13089104.46794453 19019070.272697516 1.0 2.6016855678707143 3.780368684807853 22.262416445697347 -7.8518291815409285 0.20209152976971656 4.862361627005317e-20 5.355593003752175 0.9998656858851434 0.01320555023438288 0.12473885394304497 0.03146333285713746 0.2796271663917643 0.4203479840997628 1.4066006651936813e-08 7.8518291815409285 5.355593003752175 HVLESEK(ub)NQLLQQVDHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVLESEKNQLLQQVDHLK 18 1 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 34014800.0 8912800.0 14196000.0 10906000.0 True False 11537795.297553688 13405980.120713068 8921219.90500985 1.0 1.161918700668531 0.7732170379987051 23.459864236794562 -6.793543067608935 1.4819861526339224 1.0900795569775386 0.7686597881499786 0.8126651573462694 0.06900115912217493 0.2300983749099464 0.9982120917142316 0.03663995820231164 0.08557308948189674 1.6086328469518165e-07 6.793543067608935 -0.32141976882755996 HVLFPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVLFPLK 7 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 8314700.0 1748800.0 4416100.0 2149800.0 False True 2292693.73540329 3757235.093822977 1927359.3183377443 1.0 1.6387863044263393 0.8406527608009177 21.1286122177775 -6.693610412156388 1.8540023515920805 1.399121645708497 0.8433153467452191 0.38723244015776437 0.26996730303509475 0.4089291978259584 2.7280771160412396 0.11638011730298779 0.30164366854450075 2.024834760786142e-07 6.693610412156388 -0.5558062989632778 HVLFPLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVLFPLK 7 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 25699800.0 6295100.0 12590000.0 6814700.0 False True 9550126.933455806 10343216.133881018 5467771.558010878 1.0 1.0830448857854316 0.5725339145866527 23.18708847787049 -6.86519001540963 1.1593155524428467 1.0458400629332067 0.545256030508535 0.9596380000493872 0.044935502909210966 0.14154585773685277 0.3586043571819882 0.030162203648728153 0.07086799138759593 1.3639862256927336e-07 6.86519001540963 -0.5005840324246718 HVLFPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVLFPLK 7 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 9627800.0 1748800.0 4494200.0 3384800.0 False True 2395378.619543003 4295631.383668013 2585379.9521441935 1.0 1.7932995429705996 1.0793199584612805 21.191822279300393 -10.224994556372563 4.404110432935914 0.9998315060448423 1.4363097507242994 0.3324062844674506 0.2914809448303274 205406905.5797022 105.63309287990666 350973.82949434436 0.0997816803498698 5.956696098525417e-11 10.224994556372563 0.4364782446794572 HVLFPLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVLFPLK 7 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 5592400.0 1773400.0 2158100.0 1660900.0 False True 1474660.6749407328 2146473.886950691 2008186.5108660709 1.0 1.4555713890159572 1.3617956625491356 20.491951592341877 -10.076598287731551 5.072229772760898 0.9999915339388257 1.4086835257839532 0.9620118363289875 0.038283780021977076 3.6652530808757486e-06 6.673572606579245e-07 0.037068878031474864 0.012356036870547524 8.383043355804325e-11 10.076598287731551 0.4086919918451275 HVLFPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVLFPLK 7 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 20500300.0 6295100.0 8013800.0 6191400.0 False True 8149131.044972418 7567824.985303644 5064628.729128736 1.0 0.9286664975123441 0.6214931016790243 22.95821479996294 -6.94318440838805 0.6292469443799181 1.0033507871159075 0.5302753566702755 0.9985518882653945 0.006249204204302001 0.08634361060807065 0.04821737122210463 0.0062413664468803694 0.02608972300130703 1.1397657220295358e-07 6.94318440838805 -0.47307543044563205 HVLHVQLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVLHVQLNR 9 0 Q13011;M0R248;M0QZW4;M0QYT0 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 2841960.0 888200.0 840660.0 1113100.0 False True 860004.5771760988 1176339.9219839848 821545.7177157789 1.0 1.3678298385883028 0.955280633986155 19.71398481268374 -6.671571180419882 1.9319884212722078 1.2344672281669495 0.9569424249329557 0.2859820717988567 0.15618979544733524 0.4574971545156132 3.2937204907129334 0.06505225958045753 0.17343632822235988 2.1302413945505889e-07 6.671571180419882 -0.27752480323399387 HVLHVQLNRPNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVLHVQLNRPNK 12 1 Q13011;M0R248;M0QZW4;M0QYT0 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 89400390.0 27688490.0 19742800.0 41969100.0 False True 36299878.52571856 16797251.196831647 37626540.128034584 1.0 0.4627357412485761 1.0365472738807122 25.113461384591332 -11.830130696522174 17.760132924826873 0.910572407695653 0.7746773568081669 0.0 0.2687338947239216 0.0 0.0 0.0 0.07800559622620483 1.4786633324623893e-12 11.830130696522174 -0.1358950508874861 HVLHVQLNRPNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVLHVQLNRPNK 12 1 Q13011;M0R248;M0QZW4;M0QYT0 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 88182380.0 13187100.0 12536360.0 62458920.0 False True 12768482.728753604 17542193.92425377 46099055.12456414 1.0 1.3738667543286212 3.6103784689117955 23.606083764839166 -6.935897664120246 0.6966781307125378 0.9722508981353774 4.147062203440545 0.9975757531810574 0.056748860889914654 0.0896888762311289 0.06351072665025143 0.05365415798606625 0.1962211636141813 1.1590504392304886e-07 6.935897664120246 3.174811305305168 up HVLHVQLNRPNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVLHVQLNRPNK 12 1 Q13011;M0R248;M0QZW4;M0QYT0 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 20902500.0 5759400.0 11601900.0 3541200.0 False True 8737430.86853989 9531450.298941556 2841280.267836899 1.0 1.0908756180561752 0.32518486390172774 23.05877770510447 -6.877279047836367 1.09480720925605 1.0545366595033978 0.2736631267123254 0.9714260584594064 0.05773526090772838 0.13007021879581215 0.2870522601942862 0.04071637343510929 0.09782125885146492 1.3265418390725174e-07 6.877279047836367 -0.7808735327910724 down HVLHVQLNRPNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVLHVQLNRPNK 12 1 Q13011;M0R248;M0QZW4;M0QYT0 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 88086440.0 27688490.0 31273000.0 29124950.0 False True 37925673.006307304 29891255.45401845 22246236.657173887 1.0 0.7881535931886384 0.5865746048454877 25.176671446114224 -6.97172825862121 0.21289884862006228 1.1017123632187713 0.26737006377445616 0.9999929068186246 0.00044952192561639525 0.07574582267093144 0.006987151673517391 0.005899725966871589 0.020750638709228487 1.0672637074156965e-07 6.97172825862121 -0.8343422994443151 HVLHVQLNRPNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVLHVQLNRPNK 12 1 Q13011;M0R248;M0QZW4;M0QYT0 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 43880780.0 13187100.0 15290180.0 15403500.0 False True 10965657.9375837 15207808.765476895 18624300.63226291 1.0 1.38685784765852 1.6984207184167197 23.386489040273442 -6.973581598496086 0.1496533080178578 0.6360560565977896 2.4574144775773954 0.9999985591424256 0.00034287047563339254 0.07515674413185909 0.004572786464470848 0.015955897866237124 0.038922192370306224 1.0627188929411347e-07 6.973581598496086 1.8213584209796059 HVLHVQLNRPNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVLHVQLNRPNK 12 1 Q13011;M0R248;M0QZW4;M0QYT0 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 25785000.0 5759400.0 15988700.0 4036900.0 False True 7455656.834746743 15098914.789803116 3302225.6220918973 1.0 2.025162252564432 0.4429154526938563 22.829904027196918 -6.731773668180026 1.716480288262012 1.6156999138929105 0.4434927277356037 0.5676243799810159 0.43089671255598133 0.33290574459230415 1.9222993348413107 0.19885873262014808 0.49251994618965306 1.85449783997171e-07 6.731773668180026 -1.1722071861573067 HVLHVQLNRPNKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVLHVQLNRPNKR 13 2 Q13011;M0R248;M0QZW4;M0QYT0 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 81236000.0 29110000.0 15641000.0 36485000.0 False True 38163491.90164097 13307423.76814049 32709882.1888328 1.0 0.3486951299539834 0.8570987757916966 25.185689846003086 -10.045040467557762 7.047879333089164 1.0000000738692443 0.6028969528729392 0.4485631811167188 0.2075549192788423 2.408788188820075e-07 3.2504382409589366e-08 0.20096422387980228 0.06698806214919836 9.01487133125465e-11 10.045040467557762 -0.39710312099630507 HVLHVQLNRPNKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVLHVQLNRPNKR 13 2 Q13011;M0R248;M0QZW4;M0QYT0 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 59653980.0 14073980.0 10501000.0 35079000.0 False True 13627209.208607145 14694104.061991561 25890757.552557573 1.0 1.0782915149428065 1.899931024483325 23.69998679912395 -6.925419504612676 0.7834714353738107 0.9851599931182413 2.0504893300265232 0.9955590094662604 0.02712511524089662 0.09508677271027502 0.08984802337791227 0.024069294565341428 0.07630192633101401 1.1873547538600481e-07 6.925419504612676 1.065329336908282 HVLHVQLNRPNKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVLHVQLNRPNKR 13 2 Q13011;M0R248;M0QZW4;M0QYT0 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 63868000.0 21532000.0 20465000.0 21871000.0 False True 32665618.20005574 16812860.85622519 17548187.263600167 1.0 0.5146959336038679 0.5372066481683859 24.961269607355316 -10.154830191445429 5.276450824076632 1.0000164560665663 0.5259512908859034 0.9983116588575881 0.00918996073891033 1.7790880924045343e-06 2.8498415028249207e-07 0.00889844980542684 0.0029660470743891974 7.001156867782917e-11 10.154830191445429 -0.4740651651806629 HVLHVQLNRPNKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVLHVQLNRPNKR 13 2 Q13011;M0R248;M0QZW4;M0QYT0 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 72286090.0 29110000.0 19531000.0 23645090.0 False True 39872753.66817061 18668055.83961992 18060606.72791458 1.0 0.468190784990156 0.4529560932314513 25.248899907525978 HVLHVQLNRPNKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVLHVQLNRPNKR 13 2 Q13011;M0R248;M0QZW4;M0QYT0 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 41814580.0 14073980.0 11890000.0 15850600.0 False True 11703137.953029392 11825946.210019784 19164887.175106097 1.0 1.0104936178214154 1.6375853426683062 23.480392074558225 -6.910533821171904 0.8920942007508317 0.9809101438901786 1.7195578921007924 0.9911213630979943 0.02809062327874869 0.10406613622262356 0.13686141728257165 0.02305901775215763 0.06389101713845799 1.2287574919788117e-07 6.910533821171904 0.7386477482106137 HVLHVQLNRPNKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVLHVQLNRPNKR 13 2 Q13011;M0R248;M0QZW4;M0QYT0 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 95071100.0 21532000.0 36433100.0 37106000.0 False True 27873598.459174037 34405565.95773122 30353088.739711642 1.0 1.2343424552134679 1.0889547965674138 24.732395929447765 -10.255476472889022 4.135201726063879 0.9998651606340052 1.1616486258997698 0.6223946331598318 0.05935426312791299 7.384625690214747e-05 1.3295620905935405e-05 0.057517360502180655 0.019156506047443792 5.5529469838164005e-11 10.255476472889022 0.1617834652657646 HVLLGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVLLGLR 7 0 Q9BZ67-2;Q9BZ67-3;Q9BZ67 Q9BZ67-2 FRMD8 FERM domain-containing protein 8 0 97387000.0 30941000.0 31680000.0 34766000.0 False True 40563950.63307024 26953467.48767281 31168747.819020454 1.0 0.6644685013914468 0.7683854095219652 25.273694831374833 -10.534445229223168 9.122140820586125 1.0000160623382484 0.7164269554567061 0.9084985356709069 0.04242390009457447 1.3859328900068316e-05 7.073763461593912e-07 0.04107908661028492 0.013692254878954514 2.921156136756187e-11 10.534445229223168 -0.28358910688154226 HVLLGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVLLGLR 7 0 Q9BZ67-2;Q9BZ67-3;Q9BZ67 Q9BZ67-2 FRMD8 FERM domain-containing protein 8 0 84264000.0 38868000.0 14588000.0 30808000.0 False True 37634156.61526752 20413064.475415 22738460.579811066 1.0 0.5424079164068147 0.6041974266160774 25.165539305120333 -10.378860971366539 5.853796607281354 1.0000986502943292 0.5733026715116133 0.9845163313585987 0.025225461911533 3.248453460212622e-05 3.446884858554796e-06 0.024430051972311784 0.008141482823646108 4.179641461128745e-11 10.378860971366539 -0.4267959787827159 HVLLGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVLLGLR 7 0 Q9BZ67-2;Q9BZ67-3;Q9BZ67 Q9BZ67-2 FRMD8 FERM domain-containing protein 8 0 145422000.0 39867000.0 52712000.0 52843000.0 False True 60481153.668104306 43305131.75926424 42398557.8880903 1.0 0.7160103459154399 0.7010209844996699 25.849982323204696 HVLLGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVLLGLR 7 0 Q9BZ67-2;Q9BZ67-3;Q9BZ67 Q9BZ67-2 FRMD8 FERM domain-containing protein 8 0 131242000.0 30941000.0 42147000.0 58154000.0 False True 42380723.849085145 40284806.17850908 44419222.919225216 1.0 0.9505454961543487 1.0480996756308134 25.336904892897724 -6.768896695900657 1.5787834877538327 0.9715943026511795 1.0486243251284757 0.7262937503244118 0.020836585885377255 0.26821227866301856 1.3192268769653688 0.010404179239357114 0.024790343182462905 1.702563443004646e-07 6.768896695900657 0.07703002247729618 HVLLGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVLLGLR 7 0 Q9BZ67-2;Q9BZ67-3;Q9BZ67 Q9BZ67-2 FRMD8 FERM domain-containing protein 8 0 65530000.0 38868000.0 12906000.0 13756000.0 False True 32320464.14435339 12836472.816359565 16632315.999442257 1.0 0.3971623909553968 0.51460634739517 24.94594458055461 -10.68224323010212 7.068877218922315 1.0030867937311558 0.45588436917598946 0.9662382884488062 0.04794629444184979 0.0023397821927579267 0.0001051765962459492 0.04656945225742101 0.015474599990470126 2.078532262424428e-11 10.68224323010212 -0.5472024245551663 HVLLGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVLLGLR 7 0 Q9BZ67-2;Q9BZ67-3;Q9BZ67 Q9BZ67-2 FRMD8 FERM domain-containing protein 8 0 143690000.0 39867000.0 61899000.0 41924000.0 False True 51608617.39605662 58454266.236405894 34294262.17656632 1.0 1.1326454608891023 0.6645065089301679 25.621108645297145 -6.831003141427493 1.32333744554786 1.0708304871199412 0.6516417053943953 0.9078799132011477 0.05979407840013786 0.1795777344076176 0.6146742421109993 0.03547235897720335 0.08163381240292657 1.4756958589327893e-07 6.831003141427493 -0.41918878172554597 HVLLTIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVLLTIK 7 0 Q16763 Q16763 UBE2S Ubiquitin-conjugating enzyme E2 S 0 43578000.0 11127000.0 13293000.0 19158000.0 False True 14587604.754021285 11309736.215708163 17175713.936512485 1.0 0.7752976863861403 1.1774183785571617 23.798239680217126 -6.755078785857981 1.6312050968767615 0.8686831131417493 1.178530089965557 0.6704742318375493 0.09445479012485664 0.29126536266632663 1.5262795193179055 0.045715744947132 0.1103934089077111 1.757604735953002e-07 6.755078785857981 0.3098469768238078 HVLLTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVLLTIK 7 0 Q16763 Q16763 UBE2S Ubiquitin-conjugating enzyme E2 S 0 21144800.0 8788000.0 4189800.0 8167000.0 False True 8509029.750308003 5862808.989518363 6027817.695251792 1.0 0.6890102822012282 0.7084024703326018 23.02056320602727 -10.234898741880906 5.43014306130615 1.0000211047714225 0.6987063762668907 0.9969026662713429 0.007916827653076884 2.0229086932810534e-06 2.8502415923487604e-07 0.007665971864221364 0.002555145137917063 5.822389541233766e-11 10.234898741880906 -0.3013147285045318 HVLLTIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVLLTIK 7 0 Q16763 Q16763 UBE2S Ubiquitin-conjugating enzyme E2 S 0 61652000.0 17153000.0 26571000.0 17928000.0 False True 26022355.05227362 21829197.449829422 14384522.941878442 1.0 0.8388632545355331 0.5527756005550942 24.63324819769258 -6.962305424706671 0.40162320677874336 1.0154477903867498 0.36571744994140676 0.999846378120014 0.0022922022223107615 0.07888761669041046 0.018162176432563418 0.003680534229578019 0.02395511159559444 1.0906730329990354e-07 6.962305424706671 -0.6497303404453431 HVLLTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVLLTIK 7 0 Q16763 Q16763 UBE2S Ubiquitin-conjugating enzyme E2 S 0 51743000.0 11127000.0 15194000.0 25422000.0 False True 15240952.5958686 14522678.840161044 19417847.182524763 1.0 0.9528721219235168 1.2740573176369832 23.861449741740017 -6.869605344201316 1.1361098821764661 0.9734058393779116 1.2927327208098116 0.9642914070935384 0.02676022297529553 0.13723761479277943 0.33130837597139207 0.018283521195666536 0.04325989427646606 1.3501892808351367e-07 6.869605344201316 0.3193268814319 HVLLTIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVLLTIK 7 0 Q16763 Q16763 UBE2S Ubiquitin-conjugating enzyme E2 S 0 18087600.0 8788000.0 5587700.0 3711900.0 False True 7307611.3744102605 5557597.951028383 4488041.128113528 1.0 0.760521826665542 0.6141597983480234 22.800968481461545 -10.795154271337324 0.07128938493507724 1.9667346949816498 5.85888492567215e-12 0.9999697776412036 0.0008743027522317891 2.9777420486413892 0.04194352866611221 0.8514725345856614 0.3734487119922081 1.6026759823818674e-11 10.795154271337324 -1.966734694975791 HVLLTIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVLLTIK 7 0 Q16763 Q16763 UBE2S Ubiquitin-conjugating enzyme E2 S 0 55638000.0 17153000.0 20524000.0 17961000.0 False True 22204896.636179257 19381821.357954003 14692282.295422882 1.0 0.8728624895454135 0.6616685741055963 24.40437451978503 -6.96350622807872 0.38282708595200693 1.0140536698902884 0.5129754360794182 0.9998789590239313 0.0015351551450536575 0.07847161230348126 0.016670469652040925 0.0027410182541281894 0.017821915435969508 1.0876615397117425e-07 6.96350622807872 -0.5010782338108702 HVLTGSADNSCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVLTGSADNSCR 12 0 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 18254300.0 3317000.0 8014100.0 6923200.0 False True 4348619.121873691 6818427.518717121 6206853.6760237655 1.0 1.567952337885886 1.427316005856456 22.05212592378098 -10.045810943509354 4.5024975741868385 0.9999790216141418 1.4976341717567712 0.9434841147512516 0.057414542303737826 19875529.06759153 0.11661197459651308 5183.956340622879 0.019654524941161974 8.998892348501018e-11 10.045810943509354 0.4976551501426294 HVLTGSADNSCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVLTGSADNSCR 12 0 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 3347400.0 2009500.0 778370.0 559530.0 False True 1945709.522444688 1089177.200145926 412972.30745980574 1.0 0.5597840723816928 0.2122476673398434 20.891864913662737 -7.940596759184953 0.3068609351955503 1.1139949966628455 5.294576305798792e-21 0.9991785422988346 0.009238600322842625 0.10503416702724613 0.056415846657231726 0.052353847108551205 0.08767028819174645 1.1465770398906538e-08 7.940596759184953 -1.1139949966628455 down HVLTGSADNSCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVLTGSADNSCR 12 0 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 16402200.0 3562900.0 9370300.0 3469000.0 False True 5405179.782880296 7698096.754511933 2783350.629483289 1.0 1.424207346237389 0.514941360192853 22.365911173881006 -6.779863152557376 1.5365573083542003 1.2402446797707336 0.5077907119155521 0.7668319766417465 0.17937989153611691 0.2508000181890042 1.169609609146601 0.09195150424206042 0.2169778495064668 1.6601099304527295e-07 6.779863152557376 -0.7324539678551815 HVLTGSADNSCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVLTGSADNSCR 12 0 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 20512900.0 3317000.0 8106500.0 9089400.0 False True 4543384.538554517 7748328.02538932 6942670.922069095 1.0 1.7054088113471593 1.5280834943981902 22.115335985303872 -10.063902857621919 4.572869217856652 0.9999686563597221 1.6167461527845235 0.9416198174350822 0.07239275759442215 50211516.997549385 1.2784819753608183 17086.921030221765 0.02478196644496847 8.631715991831035e-11 10.063902857621919 0.6167774964248014 HVLTGSADNSCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVLTGSADNSCR 12 0 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 3378510.0 2009500.0 389730.0 979280.0 False True 1670988.2859441745 387630.4471346519 1184042.9203208638 1.0 0.23197675914025054 0.7085884026121899 20.672270189097013 -10.031826550388105 14.38143873911487 0.9999918171424328 0.4702825644030989 0.6222161813520444 0.1945758887199467 0.0 0.0 0.18839729412055026 0.06279909804018341 9.293374737871908e-11 10.031826550388105 -0.5297092527393339 HVLTGSADNSCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVLTGSADNSCR 12 0 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 8102600.0 3562900.0 1893800.0 2645900.0 False True 4612244.285258737 1788408.365216007 2164373.34922662 1.0 0.38775230768499525 0.4692668504450655 22.137037495973455 -10.661076271016904 6.6795653620047695 1.0031127608410757 0.42850957906571907 0.9849707641641482 0.03327817272974214 0.0015474557532385643 7.851841280751276e-05 0.03232273193563881 0.010740484064542092 2.1823466133687392e-11 10.661076271016904 -0.5746031817753566 HVLVTLGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVLVTLGEK 9 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180;F8VXL3;H0YI43 P60660-2 MYL6 Myosin light polypeptide 6 0 181105000.0 60123000.0 50519000.0 70463000.0 False True 78821835.23196019 42981762.121519655 63172164.68882338 1.0 0.5453027323587573 0.8014551361677598 26.232092004771072 -10.154982496402306 5.424453390820144 1.0000085169898336 0.6733789342631813 0.6843289941546995 0.10457378095350688 1.07715966836568e-05 1.6778632382789564e-06 0.10125576727815658 0.033751042673533446 6.998702026687521e-11 10.154982496402306 -0.3266295827266523 HVLVTLGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVLVTLGEK 9 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180;F8VXL3;H0YI43 P60660-2 MYL6 Myosin light polypeptide 6 0 169914000.0 74906000.0 30208000.0 64800000.0 False True 72528150.0314714 42270211.93263891 47826936.04166963 1.0 0.5828111142266421 0.6594258370152358 26.112037714904954 -10.795598223663664 7.151736439182594 1.0130820497376796 0.6211184756209389 0.9702449767380527 0.03127782960280615 0.006450264321986535 0.0001843529706057549 0.02994153002482359 0.010094876096431803 1.601038503166499e-11 10.795598223663664 -0.39196357411674065 HVLVTLGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVLVTLGEK 9 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180;F8VXL3;H0YI43 P60660-2 MYL6 Myosin light polypeptide 6 0 329323000.0 97273000.0 153340000.0 78710000.0 False True 147570252.60886204 125975278.94911152 63152934.000181474 1.0 0.853663097555383 0.42795165613471986 27.13682668958288 -6.952140047164374 0.5348325925314705 1.0064896061253918 0.2556389683988695 0.9993587081360849 0.006144645512121504 0.0826375964282143 0.03249259686217787 0.006807424260935285 0.035227319753474526 1.1165031503796124e-07 6.952140047164374 -0.7508506377265223 down HVLVTLGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVLVTLGEK 9 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180;F8VXL3;H0YI43 P60660-2 MYL6 Myosin light polypeptide 6 0 223122000.0 60123000.0 71131000.0 91868000.0 False True 82352097.86298259 67988197.22123827 70170670.4808505 1.0 0.8255794203853438 0.8520811527788941 26.295302066293964 -10.368820651518682 8.493289431141758 1.0000007022545265 0.8388302865996264 0.980124220514497 0.010819286943997669 1.4386493278312486e-07 1.0696833303312161e-08 0.010475775117532518 0.0034919098459951945 4.2773949118187595e-11 10.368820651518682 -0.1611704156549001 HVLVTLGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVLVTLGEK 9 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180;F8VXL3;H0YI43 P60660-2 MYL6 Myosin light polypeptide 6 0 146467000.0 74906000.0 43800000.0 27761000.0 False True 62287657.898449525 43564040.706380725 33565696.7476386 1.0 0.6994008472337363 0.5388819852941383 25.89244299033923 -13.99999999999822 0.0778044683270635 2.6433522117031307 0.039441667348604235 0.9998955858281422 0.0019529602413741731 12.280451389301144 0.0778390124078688 3.5095861860505235 0.4548503770891905 1.0000000000040984e-14 13.99999999999822 -2.6039105443545263 HVLVTLGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVLVTLGEK 9 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180;F8VXL3;H0YI43 P60660-2 MYL6 Myosin light polypeptide 6 0 275628000.0 97273000.0 108010000.0 70345000.0 False True 125921816.03748989 101999148.55157919 57542931.80065257 1.0 0.8100196753929568 0.4569734904674555 26.90795301167533 -6.961455909111024 0.41440551823448085 1.0165777199369808 0.23721907250635257 0.9998204405589561 0.0030149465111874705 0.07918510015668774 0.019239579877122683 0.004553241907008532 0.02943607063530197 1.092808566787371e-07 6.961455909111024 -0.7793586474306282 down HVNTNPLCDLTPIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVNTNPLCDLTPIFK 15 0 Q9UKX7;Q9UKX7-2 Q9UKX7 NUP50 Nuclear pore complex protein Nup50 0 6228160.0 612690.0 3149300.0 2466170.0 False True 803242.5232984006 2679436.715875251 2210994.3855730784 1.0 3.3357754826929824 2.7525863253528287 19.61547612137468 -10.145207787406095 5.186852799788444 0.9999246998695813 3.0441809040246737 0.942468170634984 0.23808597650741006 0.00020734470855790754 3.417169148061889e-05 0.23053405583975806 0.07684191849733091 7.158008546530324e-11 10.145207787406095 2.0442562041550922 HVNTNPLCDLTPIFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVNTNPLCDLTPIFK 15 0 Q9UKX7;Q9UKX7-2 Q9UKX7 NUP50 Nuclear pore complex protein Nup50 0 2640390.0 612690.0 0.0 2027700.0 False True 839218.0503246818 0.0 1548799.0217923624 1.0 0.0 1.8455263458563047 19.67868618289757 -6.759535367161845 1.6140746076864938 0.4188055942989856 1.8521507939803388 0.6891220333182964 0.4205775757763143 0.283697416060279 1.4565644462474052 0.20559468769838354 0.4943318659619538 1.7396610214092252e-07 6.759535367161845 1.433345199681353 HVPGGGNVQIQNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVPGGGNVQIQNK 13 0 P27816-6;P27816;E7EVA0;P27816-2;P27816-4;H0Y2V1;F8W9U4 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 9280500.0 4337300.0 3734500.0 1208700.0 False True 5614720.350964867 3526671.792110669 988729.0023093154 1.0 0.6281117440701433 0.17609585883282797 22.420782738286086 -7.505079907312784 0.41950250067407235 1.0320764615148013 6.256845852139386e-23 0.9986461785572768 0.012395534042983956 0.11839719333859598 0.05229708905806903 0.019585552604213918 0.06702101683697542 3.1255042421036445e-08 7.505079907312784 -1.0320764615148013 down HVPVVYVDYPGPASLTQIYGTFNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVPVVYVDYPGPASLTQIYGTFNR 24 0 Q14204;A0A2R8Y706;A0A2R8Y6H2;A0A2R8YFZ7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 9983800.0 4181700.0 1439900.0 4362200.0 False True 4048954.2224468575 2014859.5789793057 3219608.956805111 1.0 0.49762468733511367 0.7951705008063643 21.949117901293288 -10.26544967528438 5.887077855248344 1.0000167556106885 0.6463975940707394 0.6531449076539859 0.1214725696843242 2.6715307448466135e-05 3.3332572053776386e-06 0.11762087803448115 0.03920510328403298 5.4268813272588476e-11 10.26544967528438 -0.3536191615399491 HVPVVYVDYPGPASLTQIYGTFNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVPVVYVDYPGPASLTQIYGTFNR 24 0 Q14204;A0A2R8Y706;A0A2R8Y6H2;A0A2R8YFZ7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 11040000.0 4181700.0 3100700.0 3757600.0 False True 3477268.8307204586 3083995.913659236 4543296.786820609 1.0 0.8869017794693371 1.306570474701917 21.729523176727565 -6.834963128529925 1.3056421838368664 0.9397438041805826 1.3190477909000853 0.9154297339548259 0.051558811302477026 0.17476682196324908 0.5808925711280922 0.030988512569687588 0.07132140456792614 1.4623013181261104e-07 6.834963128529925 0.3793039867195027 HVQGILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVQGILR 7 0 P62308;A8MWD9;C9JVQ0;Q49AN9;F5H013 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 0 35574900.0 9349900.0 14817000.0 11408000.0 False True 12257809.444560392 12606361.356213637 10227609.593263093 1.0 1.0284350897466366 0.8343749867805105 23.54719784667932 -6.869672135438336 1.1359062449039588 1.0160486067420798 0.8230842430579416 0.9643508712814016 0.016156389465028904 0.13716554227453676 0.33099695576030674 0.011041123382033087 0.02612406493994579 1.349981647807724e-07 6.869672135438336 -0.19296436368413816 HVQGILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVQGILR 7 0 P62308;A8MWD9;C9JVQ0;Q49AN9;F5H013 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 0 22239900.0 7684400.0 6416900.0 8138600.0 False True 7440462.9282279 8979201.633691438 6006856.507233526 1.0 1.2068068506363785 0.8073229535818927 22.82696095456632 -6.766022140997135 1.5898740220070438 1.119220713128641 0.8054156480867775 0.7150545063750222 0.08707532086390887 0.27290473462170545 1.3607721180319323 0.04318808899896477 0.10317723194962741 1.7138699295699727e-07 6.766022140997135 -0.31380506504186345 HVQGILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVQGILR 7 0 P62308;A8MWD9;C9JVQ0;Q49AN9;F5H013 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 0 59846000.0 18921000.0 29965000.0 10960000.0 False True 28704540.310387027 24617511.63238638 8793751.196061349 1.0 0.8576173443710675 0.3063540158098 24.77477561592818 -6.945624641039954 0.6049821713892463 1.0061474497380192 0.12936237196092765 0.9988115891184732 0.01031200743595721 0.08529184594697092 0.04361161031342004 0.01053232184611449 0.04640344258510248 1.1333795153563153e-07 6.945624641039954 -0.8767850777770916 down HVQGILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVQGILR 7 0 P62308;A8MWD9;C9JVQ0;Q49AN9;F5H013 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 0 39001900.0 9349900.0 15436000.0 14216000.0 False True 12806810.70154684 14753986.479974061 10858473.58771032 1.0 1.1520422081503896 0.8478671107708966 23.610407908202212 -6.770807518034603 1.5714451517803452 1.0871174612509458 0.8461070812896 0.7336142968129056 0.06409195101177405 0.2651237871017782 1.2922128833454165 0.032146428172277614 0.07646271180076541 1.6950889077384243e-07 6.770807518034603 -0.24101037996134578 HVQGILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVQGILR 7 0 P62308;A8MWD9;C9JVQ0;Q49AN9;F5H013 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 0 23071400.0 7684400.0 9710300.0 5676700.0 False True 6389919.0766406655 9657988.686556356 6863671.7239047615 1.0 1.5114414706537713 1.0741406333291406 22.607366230000597 -10.173469694950018 10.8180685873119 1.0000000506587883 1.2927910519916972 0.37410591008280825 0.1785273192561988 1.5191217811381315e-09 0.0 0.17285833358057703 0.057619444526859 6.707030867015086e-11 10.173469694950018 0.2927910013329089 HVQGILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVQGILR 7 0 P62308;A8MWD9;C9JVQ0;Q49AN9;F5H013 P62308 SNRPG;SNRPGP15 Small nuclear ribonucleoprotein G;Putative small nuclear ribonucleoprotein G-like protein 15 0 42568000.0 18921000.0 13218000.0 10429000.0 False True 24493607.488669466 12482406.680444187 8531029.010576537 1.0 0.5096189561385942 0.34829614275981674 24.54590193802063 -13.999999999999998 0.15540922608464758 3.3931196532811674 0.18139133982971387 0.9995492008332962 0.00588406075297491 11.982219875621233 0.12440811582730267 8.648386572855758 0.15129077891617057 1.0000000000000041e-14 13.999999999999998 -3.2117283134514536 HVSLCIFTAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVSLCIFTAR 10 0 Q9HC16 Q9HC16 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G 0 59043000.0 14527000.0 20916000.0 23600000.0 False True 22038521.06595809 17183376.382546082 18935449.655752566 1.0 0.7796973458935259 0.8591978381435631 24.39352407675955 -10.815357943646392 9.95626005919434 1.002619744571915 0.8194475929880115 0.8730498075010927 0.03245594005211328 0.0019078681663023587 3.5381996667882745e-05 0.03176703774495143 0.010475109608945087 1.5298260658630965e-11 10.815357943646392 -0.18317215158390343 HVSLCIFTAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVSLCIFTAR 10 0 Q9HC16 Q9HC16 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G 0 50861000.0 14527000.0 20952000.0 15382000.0 False True 18805487.869980544 19786002.78171177 12582633.83264821 1.0 1.0521398284644576 0.6690937198568531 24.164650398852 -6.872537429354335 1.1206539867494694 1.0299897455668015 0.6455585216601882 0.9671473031343519 0.03074435411538621 0.1344417157816379 0.3140292777384709 0.021257581731234407 0.05055942917353121 1.3411043483208267e-07 6.872537429354335 -0.3844312239066132 HVTNPAFTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVTNPAFTK 9 0 Q92922;F8WE13 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 0 6154500.0 1428400.0 2623100.0 2103000.0 False True 1872646.2326452762 2231743.7047637184 1885401.733400445 1.0 1.1917593755074527 1.0068114844826566 20.836646950691662 -10.858145352403621 2.5387577378726727 0.956685256289743 1.099285429742866 0.27758575285571074 0.07550466370477683 13824649.048981199 8365005.624336092 3617718.485194284 0.02726757218944179 1.3862917783852897e-11 10.858145352403621 0.14260017345312304 HVTNPAFTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVTNPAFTK 9 0 Q92922;F8WE13 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 0 3268700.0 1106300.0 0.0 2162400.0 False True 1071181.1120580034 0.0 1596002.5693905326 1.0 0.0 1.489946519243807 20.030770996543684 -6.725842087736739 1.738098016621539 0.39543350936295474 1.488456970418703 0.5399885580600843 0.42053328193051404 0.3440989816232057 2.03445558337252 0.1918782395975519 0.47844374247604077 1.8800002727163855e-07 6.725842087736739 1.0930234610557483 HVTNPAFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVTNPAFTK 9 0 Q92922;F8WE13 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 0 11071300.0 2211100.0 6172800.0 2687400.0 False True 3354400.353062566 5071215.611693464 2156234.2120707347 1.0 1.5118098849063877 0.6428076511803649 21.677623456469906 -6.7471025896264 1.6605524682078996 1.301993114585818 0.6414532041829266 0.6364217400020137 0.21504218125518132 0.3051234064063019 1.6544406919134158 0.10233979262314265 0.24921539523569175 1.790182924667522e-07 6.7471025896264 -0.6605399104028913 HVTNPAFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVTNPAFTK 9 0 Q92922;F8WE13 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 0 5422000.0 1428400.0 1791400.0 2202200.0 False True 1956518.0810585688 1712250.024632388 1682085.715732673 1.0 0.8751516488444512 0.8597343065813045 20.899857012214554 -13.99999999999637 0.2949911344432958 2.106660546987007 0.8557403739975429 0.9996386275876535 0.0011938805513135094 16.269254864188735 0.17235293358761516 10.957855374311242 0.005694473915500797 1.0000000000083603e-14 13.99999999999637 -1.2509201729894641 HVTNPAFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVTNPAFTK 9 0 Q92922;F8WE13 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 0 3217500.0 1106300.0 2111200.0 0.0 False True 919937.4673998705 2099826.54655961 0.0 1.0 2.282575306444036 0.0 19.81117627197796 -6.757026036297998 1.6420222558533406 1.750177722958395 2.814924826127026e-13 0.666887426403876 0.5392019872856482 0.29053387688912347 1.5462773578875102 0.26000791291052516 0.6221692144218157 1.7497417870749094e-07 6.757026036297998 -1.7501777229581135 HVTNPAFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVTNPAFTK 9 0 Q92922;F8WE13 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 0 6169700.0 2211100.0 1745700.0 2212900.0 False True 2862312.53729703 1648550.260406372 1810174.906271435 1.0 0.5759504732362836 0.6324169295575385 21.448749778562355 -10.228375916585035 5.445394963853733 1.0000248711447697 0.6041837013971273 0.9849659418821086 0.02305233426182332 6.960966532679122e-06 9.86365003006139e-07 0.022321727084645457 0.0074401088905868586 5.910498118441075e-11 10.228375916585035 -0.3958411697476424 HVVFGFVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVVFGFVK 8 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 0 16009900.0 3644100.0 4427200.0 7938600.0 False True 4777450.389514604 3766679.01709044 7117189.824428341 1.0 0.7884287035941655 1.4897464639400386 22.18780946122437 -6.825802783409518 1.3465607070634753 0.8865825695223442 1.507050794122937 0.8972161988673437 0.09416744719673299 0.18604806363742118 0.6612198301667885 0.054930007725779814 0.12645378155570114 1.493472453375776e-07 6.825802783409518 0.6204682246005928 HVVFGFVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVVFGFVK 8 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 0 6179300.0 2439400.0 1738300.0 2001600.0 False True 2361962.5822600527 2432412.2551147435 1477320.9132871283 1.0 1.0298267522880404 0.6254633008934241 21.171554679353296 -6.889146358338542 1.0274477128134847 1.0221737402591053 0.5912640751655751 0.980345229997375 0.02579483045680195 0.119837349432242 0.22592939222607228 0.019150775345599454 0.04759754824414444 1.2907842027675028e-07 6.889146358338542 -0.43090966509353024 HVVFGFVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVVFGFVK 8 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 0 12752500.0 3644100.0 5563600.0 3544800.0 False True 4991422.24809965 5317781.755635122 2707591.24744763 1.0 1.0653840711752496 0.5424488478165662 22.25101952274726 -6.875565635068898 1.104293077588413 1.0385651219404737 0.5084098609358296 0.9699262481438067 0.04034380704057953 0.13162753193930438 0.29667528193184467 0.028247083542103108 0.06759909579633917 1.3317857538810512e-07 6.875565635068898 -0.530155261004644 HVVFGFVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVVFGFVK 8 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 0 7429900.0 2439400.0 2491900.0 2498600.0 False True 2028469.1837433304 2478475.640096578 3021045.707778892 1.0 1.221845350158491 1.4893229495376725 20.951959954787572 -6.96863244628277 0.2889908303428662 0.9471018237774586 1.7723187978765207 0.999969662196364 0.001101880864535729 0.0767490004296764 0.010610553678594713 0.004698476628244605 0.024284525145080123 1.0748987397837893e-07 6.96863244628277 0.8252169740990621 HVVFGHVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVVFGHVK 8 0 P30405 P30405 PPIF Peptidyl-prolyl cis-trans isomerase F, mitochondrial 0 2057810.0 740710.0 0.0 1317100.0 False True 971077.9830458432 0.0 1180819.1265153247 1.0 0.0 1.2159879506397788 19.889227631292368 -6.688237062393281 1.8728969922017338 0.3720123541738141 1.2116697503202805 0.362046428858385 0.4230852019982448 0.4204930969468217 2.858390678955036 0.1808179827082286 0.47187391620320973 2.050042844486156e-07 6.688237062393281 0.8396573961464664 HVVFGHVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVVFGHVK 8 0 P30405 P30405 PPIF Peptidyl-prolyl cis-trans isomerase F, mitochondrial 0 2549180.0 740710.0 737570.0 1070900.0 False True 1014570.5039350969 704981.7185821753 817975.4758778125 1.0 0.6948572975932619 0.8062283229260322 19.95243769281526 -10.364658980328404 5.225062372471748 1.0001194811983936 0.7505428102596342 0.8699506274790119 0.04546703069935602 6.331349134916477e-05 7.698631165387168e-06 0.04404425714511579 0.014674421058335793 4.318580502449723e-11 10.364658980328404 -0.24957667093875935 HVVFGQVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVVFGQVIK 9 0 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 0 20881600.0 7589200.0 4431700.0 8860700.0 False True 9949514.693917347 3770507.6346312957 7943879.761836109 1.0 0.37896397468877574 0.7984188180246232 23.246194726562972 -10.016216191094493 5.488754141810805 1.0000016384015042 0.5886913963563758 0.5617969025400154 0.17124172272008795 3.4332667425523723e-06 6.155627873406183e-07 0.1658047459005202 0.055268028355688545 9.633493504865721e-11 10.016216191094493 -0.41131024204512845 HVVFGQVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVVFGQVIK 9 0 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 0 10494900.0 3482400.0 1561100.0 5451400.0 False True 3371853.118169387 2184455.371028953 4023514.801505523 1.0 0.6478500974013115 1.1932651454550693 21.68511026150453 -6.732395900010145 1.7144479710203218 0.7886406304087092 1.1930861687638112 0.5702987860437383 0.14801031481386337 0.3317947495339992 1.9116689471187136 0.06838303407778938 0.16923252184099927 1.851842726016766e-07 6.732395900010145 0.404445538355102 HVVFGQVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVVFGQVIK 9 0 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 0 23704800.0 7532800.0 12049000.0 4123000.0 False True 11427808.32144621 9898761.810733315 3308087.2428249056 1.0 0.8661994962023136 0.289476962666299 23.446045407486967 -6.943162292268826 0.6294620111096816 1.0062911038767608 0.11833207609595747 0.99854939729326 0.011741565149067223 0.08635326770043628 0.04826014689956777 0.01172461297523412 0.04898805404685762 1.1398237652179385e-07 6.943162292268826 -0.8879590277808034 down HVVFGQVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVVFGQVIK 9 0 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 0 19130200.0 7589200.0 6062100.0 5478900.0 False True 10395132.330418438 5794256.377316062 4184896.661487483 1.0 0.557400925081136 0.40258233646930663 23.309404788085864 -13.999999999999998 0.14644332259829335 3.1293018921150773 0.22508387304978197 0.9995785413103004 0.005197057735597904 11.946134229088738 0.12032559628063492 7.246892074587516 0.15946764752762002 1.0000000000000041e-14 13.999999999999998 -2.9042180190652953 HVVFGQVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVVFGQVIK 9 0 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 0 8236700.0 3482400.0 2911700.0 1842600.0 False True 2895769.896477728 2896014.0941727986 2227879.140780189 1.0 1.0000843291089418 0.7693564131217994 21.465515536938806 -6.906811790095063 0.9171791944735573 1.007883880746652 0.7414866082665569 0.9896616217422894 0.011057085960706503 0.1065640364072372 0.1504853864735759 0.008912237955964245 0.024090662395072352 1.2393335593118627e-07 6.906811790095063 -0.26639727248009504 HVVFGQVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVVFGQVIK 9 0 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 0 20410900.0 7532800.0 7588700.0 5289400.0 False True 9751358.09368689 7166382.173996575 4326783.473827165 1.0 0.7349111893076874 0.44371085876011057 23.217171729579416 -6.969917946121463 0.26013765572417186 1.0816174435925714 0.08836356702474335 0.9999817353942342 0.000970916425598469 0.0763293424411968 0.009125327786139911 0.006073477518943169 0.02746954197788463 1.071721772975412e-07 6.969917946121463 -0.993253876567828 down HVVFIAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVVFIAQR 8 0 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 0 280853000.0 93829000.0 88105000.0 98919000.0 False True 123010727.64132847 74960077.43060008 88683810.7780498 1.0 0.6093783759182919 0.7209437134347484 26.874208896127406 -10.35089229832714 8.476079122004704 1.0000010542600266 0.6651610446765214 0.9231375378389218 0.04554635831611724 9.073870095704996e-07 6.950522269885276e-08 0.04410021077680715 0.014700023936559805 4.4576678140568506e-11 10.35089229832714 -0.33484000958350524 HVVFIAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVVFIAQR 8 0 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 0 135487000.0 45759000.0 20716000.0 69012000.0 False True 44306405.59221029 28988006.832512856 50935686.88437811 1.0 0.6542622098329134 1.1496235409656734 25.40101195549866 -6.71902400011014 1.762616701323875 0.7894432000592687 1.1488210481739418 0.5080217429822711 0.1455050504219365 0.3572076645701075 2.1682987132104703 0.06555692853993308 0.16477472718660838 1.909747718606674e-07 6.71902400011014 0.3593778481146731 HVVFIAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVVFIAQR 8 0 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 0 238455000.0 75227000.0 92742000.0 70486000.0 False True 114124858.8303729 76191465.50344674 56554411.204888664 1.0 0.667614981383612 0.49554857534542174 26.766037834731424 -13.999999999873674 0.08368620338718219 2.7549271789291536 0.015007134147090411 0.9998710209789949 0.0023778933307137488 12.222530153603515 0.08244668791645862 3.907603487591504 0.43451836300534263 1.0000000002908754e-14 13.999999999873674 -2.739920044782063 HVVFIAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVVFIAQR 8 0 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 0 226230000.0 93829000.0 47976000.0 84425000.0 False True 128520116.93338309 45856261.68458383 64485553.787453786 1.0 0.3568022094809709 0.5017545527201716 26.937418957650298 -10.091068692515723 7.663127017644559 1.0000000618255858 0.4292783811022579 0.9538528907951679 0.059176546326134775 6.252630097582158e-08 7.297779541033084e-09 0.05729745100521758 0.019099148200599318 8.108327979929031e-11 10.091068692515723 -0.5707216807233279 HVVFIAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVVFIAQR 8 0 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 0 128577000.0 45759000.0 54538000.0 28280000.0 False True 38050635.967414565 54244192.96905465 34193217.24805372 1.0 1.4255791418442458 0.8986240670809228 25.181417230932936 -6.691798087809153 1.8599179865664521 1.2663611185266495 0.9004006855370769 0.37886994237355986 0.17992511153543478 0.41283479488062425 2.7702201080424986 0.07734722815871266 0.2009702900131887 2.0333021140408896e-07 6.691798087809153 -0.3659604329895726 HVVFIAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVVFIAQR 8 0 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 0 248574000.0 75227000.0 90861000.0 82486000.0 False True 97382834.44586113 85804505.47676189 67474394.37783249 1.0 0.8811050321652316 0.6928777002824261 26.537164156823874 -6.964345573489604 0.36911778285581215 1.0146203691235944 0.5528195916965817 0.9998990027972877 0.001270701995887962 0.07818382363472617 0.01564771434915059 0.002484354326377844 0.015993631791199097 1.085561485162366e-07 6.964345573489604 -0.46180077742701275 HVVFTAETHNFPTGVCPFSGATTGTGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVVFTAETHNFPTGVCPFSGATTGTGGR 28 0 O15067 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 9263600.0 1806200.0 3809400.0 3648000.0 False True 2367945.6912656785 3241052.3689248953 3270539.954086937 1.0 1.368719046589509 1.3811718597054552 21.175204562520697 -11.792743983968426 0.5297325119740375 7.295254540544713e-11 1.3802584317739828 0.9999171061961901 0.0016099027671265178 5.618255117083259 0.2619635300131197 6.38186569383308 0.0024048576536392797 1.611595388594633e-12 11.792743983968426 1.3802584317010302 HVVFTAETHNFPTGVCPFSGATTGTGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVVFTAETHNFPTGVCPFSGATTGTGGR 28 0 O15067 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 36263100.0 7479100.0 15602000.0 13182000.0 False True 11346341.495450329 12817701.201017624 10576571.92212415 1.0 1.129677015816709 0.9321570240385553 23.435723855365307 -6.729577906902858 1.7245249358219823 1.0780745834672476 0.93227825271144 0.557410541759785 0.054515017510080775 0.33703287025724094 1.963420246007311 0.025051638821698505 0.06219948227985662 1.863897788719013e-07 6.729577906902858 -0.14579633075580756 HVVFTAETHNFPTGVCPFSGATTGTGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVVFTAETHNFPTGVCPFSGATTGTGGR 28 0 O15067 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 8010900.0 1806200.0 2307700.0 3897000.0 False True 2474000.950719675 2205738.1834566006 2976608.8612343203 1.0 0.8915672335594543 1.203155908395443 21.23841462404359 -6.812715251429274 1.4031422606396988 0.941091514076495 1.2089491737639082 0.8667789135537736 0.047139055386185284 0.20312657107119933 0.7876791932502665 0.026412546809732155 0.06102444455807691 1.5391634741011475e-07 6.812715251429274 0.26785765968741315 HVVFTAETHNFPTGVCPFSGATTGTGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVVFTAETHNFPTGVCPFSGATTGTGGR 28 0 O15067 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 22724900.0 7479100.0 9204600.0 6041200.0 False True 9681842.385101626 8692355.918506311 4941763.587946589 1.0 0.897799775369414 0.5104156204351098 23.206850177457756 -6.946112064490066 0.6000129733131191 1.0043631892805789 0.3840214554425042 0.9988597659986446 0.0071205974747374536 0.08508555626098382 0.04272051038008339 0.007308072060165371 0.03255490561779591 1.1321081985795503e-07 6.946112064490066 -0.6203417338380747 HVVLGAIENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVVLGAIENK 10 0 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 0 9116500.0 2747300.0 2016400.0 4352800.0 False True 2660088.4652959914 2821559.035387089 3212671.0987990703 1.0 1.0607012030606022 1.2077309235058062 21.343042794870772 -6.956135595338199 0.48684949121641785 0.9966885732728702 1.2779450843432512 0.9995989434884153 0.0017465466764024942 0.08111154245156361 0.026459955354941687 0.002102728371118463 0.012126789014095463 1.106278328048168e-07 6.956135595338199 0.28125651107038097 HVVLGAIENK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVVLGAIENK 10 0 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 0 16370800.0 3581900.0 10889000.0 1899900.0 False True 5434004.171966352 8945772.873854687 1524383.932244249 1.0 1.6462580062056826 0.2805268240514866 22.373584242516166 -6.778000747321458 1.543424790331947 1.3668688497572334 0.2703317425988949 0.7603523215240595 0.2730763776914357 0.25368130974738073 1.1934488813865176 0.13936673044298237 0.32943304171564675 1.6672443436024644e-07 6.778000747321458 -1.0965371071583385 HVVLGAIENK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVVLGAIENK 10 0 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 0 6509500.0 2747300.0 2710600.0 1051600.0 False True 2284501.676026093 2695997.459788028 1271484.697950966 1.0 1.1801249647046594 0.5565698249618809 21.12344807030505 -6.829447097785192 1.3304697052761207 1.0962816626760659 0.53998933845029 0.9047520394576027 0.08086570863453883 0.18149093980132558 0.6285227581277264 0.04772599067042431 0.10982830334684417 1.4809926467362933e-07 6.829447097785192 -0.5562923242257759 HVVLGAIENK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HVVLGAIENK 10 0 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 0 10282100.0 3581900.0 3466100.0 3234100.0 False True 4636840.159804725 3273208.488053226 2645526.9846682884 1.0 0.705913590989747 0.570545219048418 22.144710564608616 -13.999999999997216 0.10412583188947977 2.4364250886646848 0.299816380110979 0.9997729101715005 0.00270151814678441 12.050356733309052 0.09690688798513325 3.682994979124807 0.24094997104521562 1.0000000000064093e-14 13.999999999997216 -2.1366087085537058 HVVQSISTQQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HVVQSISTQQEK 12 0 Q5QNZ2;P24539 Q5QNZ2 ATP5F1 ATP synthase F(0) complex subunit B1, mitochondrial 0 3333350.0 652750.0 1591100.0 1089500.0 False True 855761.5712399912 1353714.0820592227 976768.9912219616 1.0 1.5818822994092883 1.141403194591493 19.7068493693058 -10.416061995403371 5.657626742687303 0.999820288244053 1.3616427470003916 0.47334273258699466 0.1798248415269208 0.00040782667655582386 4.2092794910580417e-05 0.17420021475475908 0.05803821803901222 3.836524753106122e-11 10.416061995403371 0.36182245875633856 HVVQSISTQQEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HVVQSISTQQEK 12 0 Q5QNZ2;P24539 Q5QNZ2 ATP5F1 ATP synthase F(0) complex subunit B1, mitochondrial 0 5925800.0 1268400.0 3588900.0 1068500.0 False True 1924255.5324610183 2948432.7547963127 857310.5066598132 1.0 1.5322459543745872 0.4455284094017179 20.87586896455236 -6.7735239362043975 1.560938702085689 1.3039045582660123 0.4385806795900356 0.7438694659875354 0.22454428471255058 0.2607668943265205 1.2543680044066372 0.11335506262077857 0.2689722476624442 1.6845195816703983e-07 6.7735239362043975 -0.8653238786759767 down HVVQSISTQQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVVQSISTQQEK 12 0 Q5QNZ2;P24539 Q5QNZ2 ATP5F1 ATP synthase F(0) complex subunit B1, mitochondrial 0 2613800.0 652750.0 1038200.0 922850.0 False True 894089.3149054748 992328.89113171 704891.8366923522 1.0 1.1098766919461747 0.7883908519439974 19.77005943082869 -6.814431487724959 1.3955839705112942 1.0595756802552605 0.7821640907882657 0.8711567547300255 0.04789022496557217 0.200805660431605 0.7698992895490304 0.026974718871781274 0.062289528747941234 1.533093040905909e-07 6.814431487724959 -0.27741158946699485 HVVSFDSSRPTSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HVVSFDSSRPTSGK 14 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-14;A0A0C4DGN9 Q9UKT9 IKZF3 Zinc finger protein Aiolos 0 3780240.0 891700.0 596140.0 2292400.0 False True 863393.4715919022 834181.8108290307 1691951.6694741284 1.0 0.9661664562867127 1.9596530726072694 19.71965865857554 -6.899014692333124 0.9674666344981657 0.9575703442667678 2.0618777473287384 0.9860699699444927 0.05435862588152795 0.11213451410200138 0.18153445658155565 0.04221679481658231 0.10930895223530666 1.2617848472490945e-07 6.899014692333124 1.1043074030619706 HVVSFDSSRPTSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HVVSFDSSRPTSGK 14 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-14;A0A0C4DGN9 Q9UKT9 IKZF3 Zinc finger protein Aiolos 0 1636400.0 1636400.0 0.0 0.0 False True 2241421.302047215 0.0 0.0 1.0 0.0 0.0 21.095982415516534 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 HVVSFDSSRPTSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HVVSFDSSRPTSGK 14 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-14;A0A0C4DGN9 Q9UKT9 IKZF3 Zinc finger protein Aiolos 0 2430050.0 891700.0 958610.0 579740.0 False True 741488.0590079222 953445.7776608126 700960.9535851013 1.0 1.2858545273628281 0.945343549460467 19.500063934009816 -6.684033418782315 1.8873684367730232 1.1802008756405589 0.9465893107846765 0.3427836251668609 0.12104593343166524 0.4296120794254618 2.962082321295379 0.05139551819630745 0.13486513956278687 2.069982058391787e-07 6.684033418782315 -0.23361156485588241 HWELTAEGEEIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HWELTAEGEEIAR 13 0 K7ER00;Q9Y285;Q9Y285-2;K7ER16;K7EK06 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 6169500.0 1146700.0 3051900.0 1970900.0 False True 1503334.8046585978 2596568.4162130277 1766970.1742077717 1.0 1.7272056817727302 1.1753670364926092 20.51973491406103 -10.443389442239761 4.443700976759524 0.9984828062375685 1.451286359133376 0.4713750460314009 0.22528718355006877 0.003396846402298749 0.00042548266961008643 0.2188133054919879 0.07271112583325644 3.602554484659072e-11 10.443389442239761 0.45280355289580754 HWGGNVLGPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HWGGNVLGPK 10 0 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 92763000.0 26909000.0 39662000.0 26192000.0 False True 35277959.587126724 33744584.201265134 23481903.09140492 1.0 0.9565344650368857 0.6656253186472184 25.072263784668735 -6.933568637489788 0.7168929667504044 1.0038920286686401 0.6000866882107516 0.9971943192867051 0.007862943994535281 0.09082676676690479 0.06890956371065347 0.00732213769606469 0.02582524447840745 1.165282870712567e-07 6.933568637489788 -0.4038053404578885 HWGGNVLGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HWGGNVLGPK 10 0 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 52343000.0 19911000.0 14535000.0 17897000.0 False True 19278936.203730363 20338901.29902367 13209238.801508669 1.0 1.0549804763132216 0.6851642985857672 24.200522111217968 -6.869079278427143 1.1390262336490395 1.0309252620399467 0.6638882321765758 0.9637518999554529 0.031019661257459114 0.13773698401633955 0.33456930390109124 0.021147804288317393 0.04998725168337194 1.351825771195482e-07 6.869079278427143 -0.36703702986337094 HWGGNVLGPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HWGGNVLGPK 10 0 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 222640000.0 66818000.0 85670000.0 70152000.0 False True 101367791.0501263 70381519.15723485 56286426.45128613 1.0 0.6943183670879366 0.5552693401738678 26.595024077378266 -13.999999999975886 0.10607277566395314 2.4863774477358387 0.2851374985870137 0.9997630269756211 0.002859571438389548 12.03714359853205 0.09816474245972323 3.861692738528077 0.24022764365466695 1.0000000000555246e-14 13.999999999975886 -2.201239949148825 HWGGNVLGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HWGGNVLGPK 10 0 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 63396000.0 19911000.0 31234000.0 12251000.0 False True 16556878.706859637 31065736.242536448 14812627.457776023 1.0 1.8763039092426088 0.8946509616960014 23.980927386652244 -6.671369408417006 1.933327019119209 1.5587036789177446 0.8986622319263974 0.2848426867064403 0.37212132331013287 0.45794000490937165 3.301471993035921 0.15491277869127965 0.4130287142657821 2.1312313286931248e-07 6.671369408417006 -0.6600414469913473 HWGGNVLGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HWGGNVLGPK 10 0 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 227499000.0 66818000.0 87777000.0 72904000.0 False True 86497218.17969008 82892132.78781566 59636220.058209896 1.0 0.958321371857472 0.6894582428572569 26.366150399470715 -6.934321363087719 0.7104235230587184 1.0035070806435054 0.6276523158688313 0.9973215045358694 0.007122560717252017 0.09045526540263148 0.06713701046433647 0.006664714579189756 0.023776010816123426 1.163264934527252e-07 6.934321363087719 -0.37585476477467405 HWGGNVLGPK(ub)SVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HWGGNVLGPKSVAR 14 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 30792200.0 8044300.0 6995900.0 15752000.0 True False 10546155.201112008 5952138.989804613 14122134.14385346 1.0 0.5643894742964723 1.3390789225597963 23.330213797430794 -6.754148549246192 1.6345757259522404 0.7451339360071293 1.341109577489447 0.66656103699662 0.18309697201556202 0.2928803711080559 1.5408233800422586 0.08844315744642603 0.2137822014419263 1.761373470358404e-07 6.754148549246192 0.5959756414823177 HWGGNVLGPK(ub)SVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HWGGNVLGPKSVAR 14 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 55520600.0 11554000.0 7924600.0 36042000.0 True False 11187224.594339835 11088934.10624307 26601518.963176783 1.0 0.9912140417609481 2.3778479406443487 23.415348830944115 -6.905473840520718 0.9260210571701507 0.9506831548839524 2.5407183392887216 0.9890981465679068 0.06803528941808458 0.10748727178250654 0.15557117608103213 0.05448375264868129 0.14607428923293736 1.2431575144700637e-07 6.905473840520718 1.590035184404769 up HWGGNVLGPK(ub)SVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HWGGNVLGPKSVAR 14 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 65819000.0 8104000.0 11940000.0 45775000.0 True False 12294360.48175978 9809213.712354202 36727551.18610478 1.0 0.7978628678496451 2.9873494632433055 23.551493356137023 -6.884322383753345 1.0554307756143675 0.8658506292963384 3.155953684686478 0.9770067220923588 0.14980696276482622 0.12386880178972691 0.24975007161059995 0.10888082295323023 0.266437422175427 1.3052016563332717e-07 6.884322383753345 2.29010305539014 up HWGGNVLGPK(ub)SVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HWGGNVLGPKSVAR 14 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 38291700.0 8044300.0 7764400.0 22483000.0 True False 11018495.099033492 7421343.134562746 17172978.45191973 1.0 0.6735350942084389 1.5585593402338664 23.393423858953685 -6.806828295958932 1.4276712206372355 0.821401304940931 1.5729676226388432 0.8514292942222822 0.14085358469659956 0.21115278985073133 0.8487926089465719 0.07758754077942534 0.17976017656429052 1.5601692143455066e-07 6.806828295958932 0.7515663176979122 HWGGNVLGPK(ub)SVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HWGGNVLGPKSVAR 14 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 51460000.0 11554000.0 18213000.0 21693000.0 True False 9607662.928986797 18114882.95400257 26228906.002900615 1.0 1.8854619575952303 2.7299985643508267 23.19575410637839 -6.97170011028877 0.21371235373227243 0.5782496482071314 4.060886366962176 0.9999927810440793 0.001897779738834282 0.07575480147527193 0.007021259230222887 0.02456027297066348 0.08677824031172762 1.067332883213388e-07 6.97170011028877 3.4826367187550447 HWGGNVLGPK(ub)SVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HWGGNVLGPKSVAR 14 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 51630000.0 8104000.0 11812000.0 31714000.0 True False 10490787.753722195 11154651.816417512 25942377.41311958 1.0 1.0632806685522518 2.472872201986459 23.322619678229472 -6.916294636479873 0.8517496296625949 0.9645545216598891 2.6818810713007535 0.9930883297329347 0.056523994759780656 0.10040143414540602 0.11727224062999461 0.047768680025634204 0.13839275703012144 1.212565935621625e-07 6.916294636479873 1.7173265496408643 up HWILPQDYDHAQAEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HWILPQDYDHAQAEAR 16 0 Q15293-2;Q15293 Q15293-2 RCN1 Reticulocalbin-1 0 11684800.0 3468900.0 3480000.0 4735900.0 False True 4547761.49287539 2960797.564933755 4245874.497960621 1.0 0.6510450404165208 0.9336185515912144 22.116725163468868 -9.934064370585315 6.388414893181356 1.0000000321907396 0.7923317960038572 0.41865136434452543 0.11536015286747738 5.286084518348463e-08 8.72797316025239e-09 0.11169700519423621 0.037232329239301296 1.1639534968919614e-10 9.934064370585315 -0.20766823618688246 HWILPQDYDHAQAEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HWILPQDYDHAQAEAR 16 0 Q15293-2;Q15293 Q15293-2 RCN1 Reticulocalbin-1 0 11101200.0 3468900.0 4393700.0 3238600.0 False True 4751446.0734976735 4199571.805977062 2473709.3810606836 1.0 0.883851303585487 0.5206224258459733 22.17993522499176 -6.950513006141336 0.5531835362052547 1.004931135224036 0.38238520687007665 0.9992409250183582 0.005625599620143347 0.08328040679395642 0.03511496145666258 0.0060812184214169285 0.030151452411943683 1.1206938633776234e-07 6.950513006141336 -0.6225459283539594 HWMLDK ddPTM_RPMI8226_Bortezomib_1h_R1 2 HWMLDK 6 0 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 68498900.0 16148300.0 28805300.0 23545300.0 False True 21170577.680359654 24507661.52218 21109058.21846577 1.0 1.1576283789797677 0.9970941056582053 24.335557300832395 -6.650380379362665 2.007366313108773 1.1022568330891178 0.9977718558613963 0.19549039560780457 0.06727177663505202 0.5076208706197147 3.9212132131816797 0.027176001462312322 0.07450474657822696 2.2367611999993826e-07 6.650380379362665 -0.10448497722772154 HWMLDK ddPTM_RPMI8226_Bortezomib_2h_R1 2 HWMLDK 6 0 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 48554300.0 16598500.0 12209800.0 19746000.0 False True 16071589.703059545 17085236.813265864 14573930.232697664 1.0 1.0630707434009066 0.9068132339094762 23.938009302825627 -6.797116901086665 1.4674691102302229 1.0349263535841553 0.9048018408534481 0.8236735906044504 0.026952320505871482 0.2248851055947841 0.9563351475166804 0.014450509824464523 0.033670060378108276 1.595449634756362e-07 6.797116901086665 -0.13012451273070724 HWMLDK ddPTM_RPMI8226_Bortezomib_8h_R1 2 HWMLDK 6 0 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 119592000.0 44788000.0 48316600.0 26487400.0 False True 67946670.44139399 39694125.23068115 21252153.780160163 1.0 0.5841952957050119 0.3127769711466697 26.017899521232458 -8.364605189572806 0.20423554243233763 1.2889814463542215 1.0192423934804052e-08 0.9997245887935364 0.004690124990570583 0.10954682061862409 0.047686637858863117 0.1266694005518962 0.11989346155749935 4.319115425421746e-09 8.364605189572806 -1.2889814361617975 down HWMLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 HWMLDK 6 0 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 50195300.0 16148300.0 18196200.0 15850800.0 False True 22118762.90139884 17392231.717213262 12107167.497473173 1.0 0.7863112324475134 0.5473709154279821 24.398767362355287 -6.969680337754683 0.2657209554979162 1.0625661190186002 0.2639736408997057 0.9999797761901532 0.0008314057263621153 0.07640667420076068 0.00940119258499737 0.00480959680417808 0.02235644271470808 1.0723082868379621e-07 6.969680337754683 -0.7985924781188944 HWMLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 HWMLDK 6 0 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 42213200.0 16598500.0 16736200.0 8878500.0 False True 13802388.188228106 16646038.768724402 10734953.300454218 1.0 1.206025982005173 0.7777605696969118 23.718414578259903 -6.775864344778425 1.5517359701737032 1.1172816744428633 0.7747826942804471 0.7525835011070158 0.0869872140391962 0.2570455368245184 1.222149381202436 0.0441640393730306 0.10458531904765207 1.6754661390340843e-07 6.775864344778425 -0.3424989801624162 HWMLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 HWMLDK 6 0 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 100518800.0 44788000.0 26708900.0 29021900.0 False True 57978948.903468594 25222526.23599 23740211.98984093 1.0 0.4350290357623413 0.4094626142562007 25.789025843324907 -13.66007660222516 0.44470158476990035 9.999999999958765 0.40935954461042645 0.9998880113043828 0.0028843086715007638 25.124123568467144 0.22576754583470962 219.20973043611562 0.005844302667709032 2.187375773710671e-14 13.66007660222516 -9.590640455348339 HWMLDKLTGVFAPRPSTGPHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HWMLDKLTGVFAPRPSTGPHK 21 2 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 56533500.0 19556000.0 1561500.0 35416000.0 False True 25638105.38057341 1328530.2866793268 31751492.054260712 1.0 0.051818582807058165 1.2384492372950286 24.611786317001098 -6.693920650571453 1.8526617677743642 0.4077344341910545 1.2345300026905393 0.3887203650888238 0.4007027226562647 0.4083151470296222 2.720215687106839 0.1728386930113873 0.4478430577230264 2.0233888358764504e-07 6.693920650571453 0.8267955684994848 HWMLDKLTGVFAPRPSTGPHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HWMLDKLTGVFAPRPSTGPHK 21 2 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 72495700.0 19556000.0 49243400.0 3696300.0 False True 26786381.68102871 47067663.76185243 2823310.067688072 1.0 1.7571489991568294 0.10540094968062313 24.67499637852399 -6.782086445998005 1.5277754431214612 1.4275724755870403 0.09147316352807722 0.7746400514455205 0.32048462185007026 0.24737752174637548 1.1406061583444091 0.16519804488244416 0.3891182123668566 1.6516330091687257e-07 6.782086445998005 -1.336099312058963 HWNEWGAFQPQMQSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HWNEWGAFQPQMQSLR 16 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 18533100.0 3545900.0 10298000.0 4689200.0 False True 4648709.238544443 8761578.541289594 4204006.565982585 1.0 1.8847336092013645 0.9043384626264346 22.148398762178623 -6.668997097217387 1.9410976308468217 1.5652088629180565 0.9083312438924984 0.27457666295279926 0.3759025670663383 0.46340054460921504 3.3652644791151594 0.1559628214438245 0.4172134988951617 2.142904924042927e-07 6.668997097217387 -0.6568776190255581 HWNEWGAFQPQMQSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HWNEWGAFQPQMQSLR 16 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 20970400.0 7611600.0 4958600.0 8400200.0 False True 7369973.924379191 6938594.838757395 6199935.619401745 1.0 0.9414680309526151 0.8412425448199934 22.813228084270655 -6.962965398152522 0.39142228983339505 1.0060587813535415 0.7730424838164655 0.999864828806893 0.0007621209634986901 0.07865857162747886 0.017339346718896614 0.0012930460566916552 0.00842572472382422 1.089016855877343e-07 6.962965398152522 -0.2330162975370761 HWNEWGAFQPQMQSLR ddPTM_RPMI8226_Bortezomib_8h_R1 2 HWNEWGAFQPQMQSLR 16 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 105896000.0 33564200.0 36861800.0 35470000.0 False True 50919345.27170298 30283523.787442073 28459338.9529467 1.0 0.5947351370260313 0.5589101509669684 25.60171053318883 -13.999999999999998 0.3434218472573892 5.786372203543906 0.5535208979013233 0.9997419777459337 0.0032129806717168603 20.022517166491244 0.1882019612343603 69.69007795341979 0.010935396106862097 1.0000000000000041e-14 13.999999999999998 -5.232851305642583 HWNEWGAFQPQMQSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HWNEWGAFQPQMQSLR 16 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 18992800.0 3545900.0 8741100.0 6705800.0 False True 4856915.054344424 8354889.299047757 5122028.150286146 1.0 1.7202049460540714 1.0545846680403816 22.211608823701514 -10.345322483917771 5.205081024281363 0.9998484680267015 1.3873948070472546 0.31112438411396903 0.27173834059726815 0.0004780273258296928 6.012502646809397e-05 0.2632115550194148 0.08770317230492411 4.51520544792148e-11 10.345322483917771 0.38754633902055313 HWNEWGAFQPQMQSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HWNEWGAFQPQMQSLR 16 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 22112800.0 7611600.0 9560800.0 4940400.0 False True 6329382.651053833 9509294.072729794 5973414.798171315 1.0 1.5024046730918552 0.9437594671538385 22.59363335970493 -6.669740602368749 1.9385824163390997 1.3207560580650743 0.946033085346808 0.27782893803692565 0.21342345030343718 0.461678373234378 3.344825544409669 0.0886447626519812 0.23689168415234965 2.1392394438774208e-07 6.669740602368749 -0.3747229727182664 HWNEWGAFQPQMQSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HWNEWGAFQPQMQSLR 16 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 74325000.0 27490200.0 18340800.0 28494000.0 False True 35586605.81285458 17320118.35714106 23308384.3731295 1.0 0.48670329640947924 0.6549763272087626 25.084831001934816 -10.696498895376472 7.733524444680541 1.0019296840865575 0.5708398118091214 0.896615018284033 0.06869717715498042 0.002293190373548685 8.999586200384474e-05 0.06673599306843703 0.02217191858772498 2.0114123142008443e-11 10.696498895376472 -0.4310898722774361 HWPFMVVNDAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HWPFMVVNDAGR 12 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 74293400.0 20705400.0 28894000.0 24694000.0 False True 27144979.911378793 24583127.827929843 22138901.761574227 1.0 0.9056233568117301 0.815579964835189 24.69418208041379 -6.971696251722684 0.21382241240581176 1.0449036301118966 0.673775120489118 0.9999927579244235 0.0002025478326668224 0.07575600188835174 0.007025879526736511 0.0026163279165616004 0.009249902807773228 1.0673423661631669e-07 6.971696251722684 -0.37112850962277855 HWPFMVVNDAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HWPFMVVNDAGR 12 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 55628600.0 19502300.0 12572300.0 23554000.0 False True 18883210.161519308 17592484.95367839 17384500.7951464 1.0 0.9316469394345251 0.9206327020907167 24.170600709124265 -13.999999171859187 0.25691575471908057 1.492434069720777 0.9164865407014925 0.9995560793450532 0.0007396654112493738 14.282697488937115 0.16038776644757408 3.6447566162435816 0.00489469572495058 1.0000019068665086e-14 13.999999171859187 -0.5759475290192845 HWPFMVVNDAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HWPFMVVNDAGR 12 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 33395400.0 19856000.0 8389700.0 5149700.0 False True 30123003.668043192 6892492.485974703 4131859.5378063093 1.0 0.22881159402064513 0.13716625285245723 24.84436229746624 -13.999999999999998 0.30052004373416785 8.055604640213602 0.11473811039829447 0.9996509911115118 0.007229018999784689 16.622375711464183 0.17411408383169394 72.94763178180116 0.033046113567734986 1.0000000000000041e-14 13.999999999999998 -7.940866529815308 HWPFMVVNDAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HWPFMVVNDAGR 12 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 72180700.0 20705400.0 30885000.0 20590300.0 False True 28360745.922395725 29520398.57696284 15727295.210539669 1.0 1.040889356638937 0.5545444838994958 24.75739214193668 -6.886476188132665 1.0429814718434165 1.0283816915382704 0.5154887273657724 0.9785461451518052 0.03226191397085628 0.12204971201176265 0.23891100551448805 0.023670664094210134 0.058311407362237874 1.298744770560257e-07 6.886476188132665 -0.512892964172498 HWPFMVVNDAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HWPFMVVNDAGR 12 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 49458300.0 19502300.0 17252400.0 12703600.0 False True 16217026.548379738 17159457.896866713 15359864.02519007 1.0 1.0581136958538884 0.9471442856289023 23.95100598455854 -6.764414513471526 1.5959693189908728 1.0335699160050937 0.9466495949442324 0.7086896641977729 0.024460652307538713 0.27556000252176105 1.3842686502743875 0.012087634465123322 0.02892195527656127 1.7202259171945624e-07 6.764414513471526 -0.08692032106086134 HWPFMVVNDAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HWPFMVVNDAGR 12 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 46949800.0 19856000.0 13467100.0 13626700.0 False True 25703983.420274895 12717644.046467671 11146780.421749277 1.0 0.4947732745748737 0.433659648759222 24.61548861955869 -13.999999999999998 0.29796551657752657 5.555045013499034 0.4183033397840516 0.999645288009394 0.0047800161944162095 16.457119558876226 0.1733000944360214 46.162525381044 0.02228105434553811 1.0000000000000041e-14 13.999999999999998 -5.136741673714982 HWPFMVVNDAGRPK ddPTM_RPMI8226_Bortezomib_1h_R1 2 HWPFMVVNDAGRPK 14 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 884589000.0 265775900.0 301919000.0 316894100.0 False True 348434778.6774766 256873862.07104427 284104938.3948521 1.0 0.7372222228964569 0.8153748011986759 28.376313391420737 -10.142412342051646 7.207635990749199 1.00000014739719 0.7762985120475664 0.91613696787696 0.03190565648722415 7.556957538672244e-08 9.005343275084037e-09 0.03089253931074583 0.01029750635206948 7.204231466897429e-11 10.142412342051646 -0.22370163534962362 HWPFMVVNDAGRPK ddPTM_RPMI8226_Bortezomib_2h_R1 2 HWPFMVVNDAGRPK 14 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 688621500.0 202520200.0 189919300.0 296182000.0 False True 196091307.10495296 265755066.9060659 218603048.93045983 1.0 1.3552618462776995 1.1148023446723114 27.546950340143738 -10.31512131319418 4.697546746511505 0.9998574794381903 1.2350320954753786 0.5602120923700005 0.09816718045747137 0.00014661512934635408 2.137573452936754e-05 0.09510737154483472 0.031683321254479306 4.8403714069058085e-11 10.31512131319418 0.23517461603718837 HWPFMVVNDAGRPK ddPTM_RPMI8226_Bortezomib_8h_R1 2 HWPFMVVNDAGRPK 14 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 1705984000.0 596607300.0 574895400.0 534481300.0 False True 905096891.9360062 472300824.1917387 428840836.78352374 1.0 0.5218234958043941 0.47380655110441416 29.753497002160145 -13.999999999999998 0.3248757229115494 6.047564542847713 0.4647839799722372 0.999704108252712 0.004086084189432571 18.399717928035006 0.18200265866491777 63.288979571757935 0.01568803802716814 1.0000000000000041e-14 13.999999999999998 -5.582780562875476 HWPFMVVNDAGRPK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 HWPFMVVNDAGRPK 14 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 996742130.0 265775900.0 329697530.0 401268700.0 False True 364040432.5536362 315130402.96066624 306497297.4482878 1.0 0.8656467105868418 0.8419320219413533 28.43952345294363 -13.999999999440838 0.2439647457418765 1.9066833806599335 0.8318339173189404 0.9995317144673368 0.0015061477917453282 13.76672655293872 0.15631160331852967 6.095165651842673 0.01132397692999338 1.0000000012875172e-14 13.999999999440838 -1.074849463340993 HWPFMVVNDAGRPK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 HWPFMVVNDAGRPK 14 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 593838800.0 202520200.0 226652800.0 164665800.0 False True 168404519.466072 225431776.37934145 199096657.4513639 1.0 1.3386325800167054 1.1822524602225735 27.327355615578014 -10.460874376715108 5.748258655313238 0.9997926622609243 1.2604425201196396 0.7871560116213515 0.06384191656848918 0.00016977151509143607 1.592269413268354e-05 0.06186341286814273 0.020604889971643385 3.4603945813736916e-11 10.460874376715108 0.2606498578587153 HWPFMVVNDAGRPK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 HWPFMVVNDAGRPK 14 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 1651069800.0 596607300.0 519316200.0 535146300.0 False True 772319910.7380624 490415796.9543712 437755164.46473247 1.0 0.6349904879257983 0.5668054887338003 29.524623324252595 -13.999999999999998 0.23592626111598106 3.369202411640034 0.5354689648282847 0.9995184343909531 0.0041735663567830745 13.4830730364846 0.15375428736703775 15.014355033986467 0.03413427271247048 1.0000000000000041e-14 13.999999999999998 -2.8337334468117494 HWPFQVINDGDKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HWPFQVINDGDKPK 14 1 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 153272400.0 37183500.0 44428400.0 71660500.0 False True 48747928.585526206 37799855.90054683 64245758.87605452 1.0 0.7754146072941039 1.3179177195875722 25.53883758086085 -6.794284768588973 1.4792616413184674 0.8751767606496211 1.3243814279588841 0.8148965447677607 0.09575594208842257 0.2290138395521252 0.9898590828374174 0.05094132346187139 0.11890005241497217 1.6058879207282625e-07 6.794284768588973 0.449204667309263 HWPFQVINDGDKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HWPFQVINDGDKPK 14 1 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 117310200.0 38624600.0 29388600.0 49297000.0 False True 37398483.21503713 41123621.23952441 36384636.82170043 1.0 1.0996066605981891 0.9728907082271975 25.156476423561923 -6.697089278953013 1.8413373466156735 1.0620271684763638 0.9732884563870525 0.40376522994509656 0.04206795812836515 0.4015923715938883 2.6451013358106557 0.01824106169539051 0.04707896687005231 2.0086798410541194e-07 6.697089278953013 -0.08873871208931128 HWPFQVINDGDKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HWPFQVINDGDKPK 14 1 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 184847800.0 37183500.0 86581000.0 61083300.0 False True 50931244.796304464 82755565.13492055 46656682.5900524 1.0 1.6248486654095138 0.9160719078564085 25.60204764238374 -6.673953733261966 1.9234679874729506 1.3974744968359194 0.918887664787109 0.2966603262370102 0.26518257362062686 0.45208318062838876 3.2282749914767765 0.11084617004469544 0.2946229005009728 2.1185868228512977e-07 6.673953733261966 -0.47858683204881036 HWPFQVINDGDKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HWPFQVINDGDKPK 14 1 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 70393400.0 38624600.0 28978500.0 2790300.0 False True 32118066.259905137 28822387.06871812 3373738.8291104767 1.0 0.8973886172188017 0.10504177934653906 24.9368816989962 -7.0059165747534005 0.8031160011245406 1.006810192453876 1.3272596909616343e-22 0.9962492975812769 0.024491174777059192 0.08014693621055206 0.08494678535194515 0.022307705282514953 0.060214046092007985 9.864689619336604e-08 7.0059165747534005 -1.006810192453876 down HWPTFISDIVGASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HWPTFISDIVGASR 14 0 O14980;C9JKM9 O14980 XPO1 Exportin-1 0 3215910.0 644550.0 1541860.0 1029500.0 False True 845011.2918310788 1311820.4981232064 922977.2156613232 1.0 1.5524295483443606 1.0922661325167593 19.68861109460069 -10.354102305426045 3.995838806700076 0.9991587544693755 1.3223478404455673 0.3955076554952668 0.18786092791816084 134057371.37047581 1313.1396591384434 1043588.2526023604 0.06430934510295236 4.424841254491573e-11 10.354102305426045 0.3231890859761918 HWPTFISDIVGASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HWPTFISDIVGASR 14 0 O14980;C9JKM9 O14980 XPO1 Exportin-1 0 11768150.0 644550.0 1303900.0 9819700.0 False True 882857.5533088075 1246289.3865793047 7500489.103069708 1.0 1.411653988696606 8.495695681550309 19.751821156123583 -6.918835944123877 0.8333124703626584 0.8370399868208843 9.60803254126777 0.9938514328499277 0.2697858176470783 0.0988616913433268 0.10919844697600767 0.2310262930329806 0.6845190877201868 1.2054912318375313e-07 6.918835944123877 8.770992554446886 up HYAHTDCPGHADYVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYAHTDCPGHADYVK 15 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 68296000.0 11266000.0 30562000.0 26468000.0 False True 14769835.100099191 26002268.729742944 23729345.258983858 1.0 1.760498242094004 1.606608678984134 23.816150383232507 -10.061232275694996 4.5970771107461745 0.9999678310968594 1.683553460454981 0.9633788696048201 0.06282515115524052 21781937.647304796 0.10162238312569888 7620.457435582734 0.021506720277207524 8.68495803483778e-11 10.061232275694996 0.6835856293581217 HYAHTDCPGHADYVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HYAHTDCPGHADYVK 15 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 17853200.0 8686600.0 4065400.0 5101200.0 False True 8410848.637804445 5688735.420780928 3765042.6872803248 1.0 0.6763568892693694 0.4476412368613431 23.003819942192692 -7.901307623930211 0.15412475512288717 1.3327323550549734 5.142148385473009e-12 0.9999537177136757 0.0015416200873851265 0.11849644611696268 0.02359391082890074 0.07922362565147975 0.10397327020684943 1.2551405946647783e-08 7.901307623930211 -1.3327323550498313 down HYAHTDCPGHADYVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYAHTDCPGHADYVK 15 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 133516900.0 31812900.0 71362000.0 30342000.0 False True 48262495.1345231 58626893.54614917 24344890.400628958 1.0 1.2147505714890445 0.504426684380323 25.52439916793656 -6.825612246650091 1.34733454378614 1.1151421224683715 0.48696113475084923 0.8968221297448684 0.0955437765942624 0.18628970737467068 0.662890277788122 0.05570076015483562 0.12823579932339207 1.494127823970958e-07 6.825612246650091 -0.6281809877175223 HYAHTDCPGHADYVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYAHTDCPGHADYVK 15 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 75179000.0 11266000.0 32339000.0 31574000.0 False True 15431344.652202351 30910156.04922784 24116871.486941844 1.0 2.0030759953777824 1.5628496434042058 23.8793604447554 -10.151905779299247 4.707610430323175 0.9999203420256384 1.7829628193978846 0.8083422675147579 0.17972165563403517 125744725.05457981 16.217759418211376 108580.21565562363 0.06152350303577743 7.04845969546087e-11 10.151905779299247 0.7830424773722462 HYAHTDCPGHADYVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYAHTDCPGHADYVK 15 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 19930500.0 8686600.0 2921500.0 8322400.0 False True 7223292.781628599 2905761.299627653 10062575.361570107 1.0 0.40227654997150836 1.3930731683980486 22.784225217626968 -6.743344123819217 1.6742804386735828 0.6457482425245046 1.3941104706260128 0.6199513495092319 0.2511278144520387 0.3117889588370528 1.7173187808437902 0.11859434109705749 0.2899778674224048 1.805742734713799e-07 6.743344123819217 0.7483622281015082 HYAHTDCPGHADYVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYAHTDCPGHADYVK 15 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 100039900.0 31812900.0 36258000.0 31969000.0 False True 41182426.17601041 34240210.42665648 26150970.02964056 1.0 0.8314277133726058 0.6350031423081631 25.29552549002901 -6.969114861388059 0.2785303501429754 1.0440461513193338 0.4164113366266605 0.9999746244990818 0.0007513271131983678 0.07659109544402455 0.010054664783454577 0.0036591916462854774 0.01806298252716865 1.0737054031994282e-07 6.969114861388059 -0.6276348146926732 HYCGK(ub)CCLTYCFNKPEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYCGKCCLTYCFNKPEDK 18 2 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 24137600.0 7057200.0 8930400.0 8150000.0 True False 9252057.542022018 7598019.1304265605 7306716.180320317 1.0 0.8212248027984086 0.7897395954504028 23.141342807988686 -13.999999999375081 0.2442817005395836 2.208350640114513 0.7763729609091927 0.9995322739064683 0.0020025002775446647 13.778417719941784 0.15641118529466017 8.142100344780985 0.015007046962647642 1.0000000014389287e-14 13.999999999375081 -1.4319776792053205 HYCGK(ub)CCLTYCFNKPEDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYCGKCCLTYCFNKPEDK 18 2 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 67584000.0 15953000.0 19547000.0 32084000.0 True False 24201867.3205224 16058685.128591914 25742583.337083213 1.0 0.6635308307377864 1.0636610388841499 24.528615028658784 -6.683737976666785 1.8887751630450849 0.7878259623668292 1.062178315661659 0.3412051381605259 0.14248933112303974 0.4302909462121034 2.971037545574293 0.06046552543534354 0.15870431743120633 2.0713907061349077e-07 6.683737976666785 0.2743523532948299 HYCGK(ub)CCLTYCFNKPEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYCGKCCLTYCFNKPEDK 18 2 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 23257900.0 7057200.0 8722900.0 7477800.0 True False 9666437.553659016 8337493.435227105 5711697.65012523 1.0 0.8625197637645868 0.5908792787848914 23.204552869511577 -6.960281766838839 0.4314448055309274 1.0106260773202416 0.43233111968968635 0.9997805051001171 0.002518455178349181 0.07960062892512716 0.020760578005366456 0.0035471428227165135 0.02254710447943067 1.0957670404477464e-07 6.960281766838839 -0.5782949576305552 HYCGK(ub)CCLTYCFNKPEDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYCGKCCLTYCFNKPEDK 18 2 P62979;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 56462000.0 15953000.0 21507000.0 19002000.0 True False 20651472.98064289 20310116.543827586 15543830.976984892 1.0 0.9834706010009424 0.7526742035086064 24.299741350751233 -6.921325101385077 0.81484431738036 1.0048532573911682 0.7142984100660582 0.9945410289595106 0.008341326979965605 0.09739838774535058 0.10162192894187257 0.007237791008793305 0.021962848459002454 1.1986017256275707e-07 6.921325101385077 -0.29055484732510994 HYCLCWATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYCLCWATK 9 0 Q9UIC8-3;Q9UIC8;Q9UIC8-2 Q9UIC8-3 LCMT1 Leucine carboxyl methyltransferase 1 0 18973000.0 5761100.0 7402900.0 5809000.0 False True 7552857.890571768 6298416.176278194 5207940.403862665 1.0 0.8339116487469607 0.6895324232650712 22.848591211696107 -6.972764803474032 0.18030531285426865 1.1111621987589593 0.4083764191554847 0.999996688618781 0.00023076128496975467 0.07541537145280808 0.005688182152392603 0.005544864145832124 0.01618750631622463 1.0647194716107846e-07 6.972764803474032 -0.7027857796034745 HYELYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYELYR 6 0 A0A087X142;A6NMH6;A6NFQ9;F8W8I8;Q92599-3;Q92599-2;Q92599-4;Q92599;E7EW69;E7EX04;B5ME97;Q9P0V9-3;Q9P0V9;Q9P0V9-2;D6RDU5;D6RGI3;D6RER5;Q9NVA2;Q9NVA2-2;H0Y961;Q14141;B1AMS2;Q14141-2;Q14141-4 A0A087X142;D6RDU5;Q14141 SEPT8;SEPT10;SEPT11;SEPT6 Septin-8;Septin-10;Septin-11;Septin-6 0 5544300.0 1207000.0 2542600.0 1794700.0 False True 1582388.6886046277 2163253.990977173 1609001.6599780242 1.0 1.3670813034468545 1.0168182264983605 20.59367258774798 -9.474853307545027 9.895752359926757 1.0000000000000253 1.1919497649585624 0.28593293907040485 0.14299430237683536 0.0 0.0 0.1384536379270077 0.04615121264233589 3.3507860016749933e-10 9.474853307545027 0.1919497649585371 HYELYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HYELYR 6 0 A0A087X142;A6NMH6;A6NFQ9;F8W8I8;Q92599-3;Q92599-2;Q92599-4;Q92599;E7EW69;E7EX04;B5ME97;Q9P0V9-3;Q9P0V9;Q9P0V9-2;D6RDU5;D6RGI3;D6RER5;Q9NVA2;Q9NVA2-2;H0Y961;Q14141;B1AMS2;Q14141-2;Q14141-4 A0A087X142;D6RDU5;Q14141 SEPT8;SEPT10;SEPT11;SEPT6 Septin-8;Septin-10;Septin-11;Septin-6 0 4919000.0 1325900.0 1666300.0 1926800.0 False True 1283810.0302609664 2331662.2796397083 1422113.2772390288 1.0 1.8162050651417172 1.10772874780387 20.2920003070828 -10.264726857390363 4.3527061716921285 0.9997111148636044 1.4619669064773706 0.36179895245140437 0.28923424541656717 204615673.33178043 294.38732028513346 597165.8205409757 0.09901257538173178 5.4359210761746765e-11 10.264726857390363 0.4622557916137662 HYELYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYELYR 6 0 A0A087X142;A6NMH6;A6NFQ9;F8W8I8;Q92599-3;Q92599-2;Q92599-4;Q92599;E7EW69;E7EX04;B5ME97;Q9P0V9-3;Q9P0V9;Q9P0V9-2;D6RDU5;D6RGI3;D6RER5;Q9NVA2;Q9NVA2-2;H0Y961;Q14141;B1AMS2;Q14141-2;Q14141-4 A0A087X142;D6RDU5;Q14141 SEPT8;SEPT10;SEPT11;SEPT6 Septin-8;Septin-10;Septin-11;Septin-6 0 20202800.0 7393600.0 8398200.0 4411000.0 False True 11216631.744563056 6899475.594563909 3539163.916590016 1.0 0.6151111805830867 0.3155282260474964 23.419136176615055 -7.804724830489788 0.23544525333472982 1.1763030545398725 3.9345616679493745e-15 0.9997807703421161 0.004148112668631939 0.12269608853763998 0.034753240899758654 0.051458767840398545 0.08723682273072059 1.5677440800384067e-08 7.804724830489788 -1.1763030545398685 down HYELYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYELYR 6 0 A0A087X142;A6NMH6;A6NFQ9;F8W8I8;Q92599-3;Q92599-2;Q92599-4;Q92599;E7EW69;E7EX04;B5ME97;Q9P0V9-3;Q9P0V9;Q9P0V9-2;D6RDU5;D6RGI3;D6RER5;Q9NVA2;Q9NVA2-2;H0Y961;Q14141;B1AMS2;Q14141-2;Q14141-4 A0A087X142;D6RDU5;Q14141 SEPT8;SEPT10;SEPT11;SEPT6 Septin-8;Septin-10;Septin-11;Septin-6 0 5518700.0 1207000.0 1999400.0 2312300.0 False True 1653260.51794854 1911059.8968683672 1766182.3633133483 1.0 1.1559339112747453 1.0683025113942286 20.656882649270873 -10.287934575267151 5.518201301545289 0.9999868066280253 1.11211821133449 0.6857901996568563 0.035775369192187 5.807524679674515e-06 7.493762659878786e-07 0.034643427439158776 0.011546450757145265 5.153062675703056e-11 10.287934575267151 0.11213140470646477 HYELYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYELYR 6 0 A0A087X142;A6NMH6;A6NFQ9;F8W8I8;Q92599-3;Q92599-2;Q92599-4;Q92599;E7EW69;E7EX04;B5ME97;Q9P0V9-3;Q9P0V9;Q9P0V9-2;D6RDU5;D6RGI3;D6RER5;Q9NVA2;Q9NVA2-2;H0Y961;Q14141;B1AMS2;Q14141-2;Q14141-4 A0A087X142;D6RDU5;Q14141 SEPT8;SEPT10;SEPT11;SEPT6 Septin-8;Septin-10;Septin-11;Septin-6 0 4627600.0 1325900.0 2279100.0 1022600.0 False True 1102544.597329376 2266822.0359340687 1236420.9320318163 1.0 2.0559912419187834 1.121424870274382 20.072405582517078 -6.616713999412946 2.128397504034573 1.7022646894717477 1.1248905757282996 0.07200175155286714 0.45448828835953564 0.5942794239967883 5.110738850258644 0.17572039389754496 0.5042521412371033 2.4170520375640024e-07 6.616713999412946 -0.577374113743448 HYELYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYELYR 6 0 A0A087X142;A6NMH6;A6NFQ9;F8W8I8;Q92599-3;Q92599-2;Q92599-4;Q92599;E7EW69;E7EX04;B5ME97;Q9P0V9-3;Q9P0V9;Q9P0V9-2;D6RDU5;D6RGI3;D6RER5;Q9NVA2;Q9NVA2-2;H0Y961;Q14141;B1AMS2;Q14141-2;Q14141-4 A0A087X142;D6RDU5;Q14141 SEPT8;SEPT10;SEPT11;SEPT6 Septin-8;Septin-10;Septin-11;Septin-6 0 20203900.0 7393600.0 5601400.0 7208900.0 False True 9571160.94964466 5289677.165973673 5896954.169560371 1.0 0.552668291109456 0.6161169162847796 23.190262498707504 -10.471653977009641 6.106415994262434 1.0002468213154168 0.5843926036971963 0.9828203884857922 0.025902792760108404 8.709032831327535e-05 7.53535656073589e-06 0.025094861981928437 0.008360090415013472 3.375561485226658e-11 10.471653977009641 -0.4158542176182205 HYFQNTQGLIFVVDSNDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYFQNTQGLIFVVDSNDR 18 0 P84077;P61204;F5H423;F5H0C7;P18085;C9JPM4;C9JAK5;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 10719000.0 3464900.0 5038100.0 2216000.0 False True 4542517.454139332 4286435.118359983 1986709.5773729847 1.0 0.9436254591501907 0.4373587107656816 22.115060627196197 -6.928011265541046 0.7629400431776038 1.0082934794284455 0.33849974078606154 0.9961327376417188 0.015732957589181664 0.09368370228183302 0.08283616008154979 0.014167444236525174 0.04631946306403785 1.1802900186886711e-07 6.928011265541046 -0.669793738642384 down HYFQNTQGLIFVVDSNDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HYFQNTQGLIFVVDSNDR 18 0 P84077;P61204;F5H423;F5H0C7;P18085;C9JPM4;C9JAK5;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 43427600.0 12469000.0 9021600.0 21937000.0 False True 12073178.420185523 12623971.927022506 16191041.604106583 1.0 1.0456212513115928 1.3410753192412261 23.5253021984148 -6.934240044284922 0.7111208770415756 0.9961357920434913 1.4088464701378742 0.9973080509149013 0.007843977691645897 0.09049496115224437 0.06732598460624584 0.007335954173020793 0.02613827141201278 1.1634827686754681e-07 6.934240044284922 0.4127106780943829 HYFQNTQGLIFVVDSNDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYFQNTQGLIFVVDSNDR 18 0 P84077;P61204;F5H423;F5H0C7;P18085;C9JPM4;C9JAK5;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 67601000.0 13796000.0 33072000.0 20733000.0 False True 20929540.622699637 27170043.2072846 16635113.462403283 1.0 1.2981672028585605 0.7948150302143406 24.319037310796737 -6.746210526711968 1.663768789030995 1.1761219012914805 0.7940916071839652 0.6325227281510267 0.12527591327245965 0.3067140920840206 1.6692044029198432 0.05951054813720542 0.1450607226200424 1.7938638303696108e-07 6.746210526711968 -0.3820302941075153 HYFQNTQGLIFVVDSNDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYFQNTQGLIFVVDSNDR 18 0 P84077;P61204;F5H423;F5H0C7;P18085;C9JPM4;C9JAK5;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 13207200.0 3464900.0 3993200.0 5749100.0 False True 4745967.165401735 3816767.220253461 4391280.98643116 1.0 0.8042127320386508 0.9252657747916484 22.17827068871909 -10.334948905957196 5.235278662180142 1.0000446110377508 0.8647392534384212 0.6247204754976247 0.04941969775939312 2.5741214115249358e-05 3.2699182735562333e-06 0.047866185178123764 0.01595013886638972 4.624354229780383e-11 10.334948905957196 -0.1353053575993296 HYFQNTQGLIFVVDSNDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYFQNTQGLIFVVDSNDR 18 0 P84077;P61204;F5H423;F5H0C7;P18085;C9JPM4;C9JAK5;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 35206700.0 12469000.0 13699000.0 9038700.0 False True 10368525.970359745 13625200.767961409 10928650.379773093 1.0 1.3140923605642154 1.054021604518768 23.305707473849075 -10.353574299383103 5.484124222081831 0.99994753647939 1.1840569825414482 0.40041539349097754 0.10617344155520761 6.812735805908517e-05 8.030502084917776e-06 0.10283125125423304 0.034267330912735774 4.4302241544194525e-11 10.353574299383103 0.18410944606205815 HYFQNTQGLIFVVDSNDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYFQNTQGLIFVVDSNDR 18 0 P84077;P61204;F5H423;F5H0C7;P18085;C9JPM4;C9JAK5;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 47126000.0 13796000.0 22530000.0 10800000.0 False True 17859193.959816303 21276185.694538295 8834510.817357987 1.0 1.1913295606963181 0.4946757864456755 24.090163632889187 -6.8334885055293055 1.3122624515712673 1.1020111278047855 0.47455857073247565 0.9126765850522895 0.08684294340473515 0.17654048667950592 0.5933181548458476 0.051940955777490305 0.119534153695577 1.4672749207545817e-07 6.8334885055293055 -0.6274525570723098 down HYFQNTQGLIFVVDSNDRER ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYFQNTQGLIFVVDSNDRER 20 1 P84077;P61204;F5H423;F5H0C7;P18085;C9JPM4;C9JAK5;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 39297000.0 10966000.0 17866000.0 10465000.0 False True 16636223.721986378 14677672.712304885 8396588.16302756 1.0 0.8822719000170045 0.5047171944394242 23.987824655632682 -6.949941728254756 0.5594836150911915 1.0049513135072374 0.36400984495343325 0.9991966975844361 0.005987916878418685 0.08350916641555382 0.036059359642310496 0.006422714848836591 0.031381511979835824 1.12216901195992e-07 6.949941728254756 -0.6409414685538042 HYFQNTQGLIFVVDSNDRER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYFQNTQGLIFVVDSNDRER 20 1 P84077;P61204;F5H423;F5H0C7;P18085;C9JPM4;C9JAK5;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 41438000.0 10966000.0 16339000.0 14133000.0 False True 14195703.172176389 15429720.286864676 11560939.01682597 1.0 1.0869289178366988 0.8143970662535011 23.75895097772513 -6.820913222928665 1.3681042725158674 1.0468092896927659 0.8083386216880879 0.8864433614577394 0.03830320203387057 0.1922890605241099 0.7069813531567823 0.02200076345824359 0.05069163724866945 1.5103819158288282e-07 6.820913222928665 -0.23847066800467798 HYGFQLYQSDPSGNYGGWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYGFQLYQSDPSGNYGGWK 19 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0;H0YLC2;H0YMV3 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 97347100.0 28715700.0 44423400.0 24208000.0 False True 37646560.78323436 37795601.88105692 21703188.379533067 1.0 1.0039589565347211 0.5764985679435142 25.166014737140443 -6.904808734137126 0.9303540494348012 1.0155043608434489 0.5269751295578844 0.9888109036396006 0.021217070205898563 0.10795209200958271 0.1581249054056353 0.0169366380634668 0.04523119783053834 1.2450628240888404e-07 6.904808734137126 -0.48852923128556447 HYGFQLYQSDPSGNYGGWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HYGFQLYQSDPSGNYGGWK 19 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0;H0YLC2;H0YMV3 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 148346200.0 50554000.0 32246800.0 65545400.0 False True 48949190.941860534 45123115.40484052 48377093.42014898 1.0 0.9218357757625771 0.9883124212943364 25.544781678610235 -10.361054075982722 6.81859736809829 1.0000019759760201 0.9550740985284568 0.3784834113074068 0.02713897689411291 8.152554224544097e-07 7.638252620924906e-08 0.026278357103592446 0.00875906712866726 4.354576494957753e-11 10.361054075982722 -0.044927877447563325 HYGFQLYQSDPSGNYGGWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYGFQLYQSDPSGNYGGWK 19 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0;H0YLC2;H0YMV3 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 279777000.0 110112000.0 96559000.0 73106000.0 False True 167047954.26549023 79327292.03108963 58656567.05650198 1.0 0.47487736308948947 0.3511360992980421 27.315687074072866 -13.999999999999911 0.20305742160670526 3.9536594795840356 0.2731511676386337 0.9994873160523159 0.006368994652379892 12.592994007575827 0.1428694548980174 14.792145346326333 0.07703275178364002 1.0000000000002045e-14 13.999999999999911 -3.680508311945402 HYGFQLYQSDPSGNYGGWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYGFQLYQSDPSGNYGGWK 19 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0;H0YLC2;H0YMV3 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 108357600.0 28715700.0 35694000.0 43947900.0 False True 39332670.30261379 34116921.05572649 33568311.155411854 1.0 0.8673939702857985 0.853446025839266 25.229224798663335 -13.999999999999996 0.31815203115951335 2.344837555284686 0.8506194728398824 0.9996897455466662 0.0011632975333772787 17.87117898151279 0.1798004544548227 15.981497204875744 0.004677642992799358 1.0000000000000082e-14 13.999999999999996 -1.4942180824448035 HYGFQLYQSDPSGNYGGWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYGFQLYQSDPSGNYGGWK 19 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0;H0YLC2;H0YMV3 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 143784600.0 50554000.0 68665600.0 24565000.0 False True 42037890.921931714 68295684.78374556 29701427.92427298 1.0 1.6246220561011735 0.706539440321383 25.32518695404451 -6.723536676079562 1.7469025672654495 1.3785742735047062 0.7077077134557078 0.5290383145510158 0.26273517104827643 0.34847754614825877 2.080197039496847 0.11934231907635433 0.29831941787195515 1.8900066137778424e-07 6.723536676079562 -0.6708665600489984 HYGFQLYQSDPSGNYGGWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYGFQLYQSDPSGNYGGWK 19 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0;H0YLC2;H0YMV3 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 298218800.0 110112000.0 108739400.0 79367400.0 False True 142542154.63201606 102687956.80038528 64923347.57829429 1.0 0.7204041293291968 0.4554677017889837 27.086813396165315 -6.97177790403488 0.21145502368117086 1.136160527547387 0.03230317099786987 0.9999931279991036 0.0005828016418080829 0.07572996071305971 0.006926829043216726 0.007842739049284543 0.027362187053288346 1.0671417124971439e-07 6.97177790403488 -1.103857356549517 down HYGGLTGLNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYGGLTGLNK 10 0 P18669;P15259;Q8N0Y7 P18669 PGAM1;PGAM2;PGAM4 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2;Probable phosphoglycerate mutase 4 0 114191000.0 30516000.0 46450000.0 37225000.0 False True 40006771.51736438 39519841.0606819 33373314.087414023 1.0 0.9878287990204074 0.8341916336070457 25.253740874404222 -6.922678497160312 0.8046293812773733 1.0030740295908007 0.8078243099486149 0.9948927362474962 0.005392598637798396 0.09662162747665232 0.09764070792348833 0.004713405002664442 0.014501211075815042 1.1948723263563932e-07 6.922678497160312 -0.19524971964218585 HYGGLTGLNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HYGGLTGLNK 10 0 P18669;P15259;Q8N0Y7 P18669 PGAM1;PGAM2;PGAM4 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2;Probable phosphoglycerate mutase 4 0 112035000.0 34477000.0 24647000.0 52911000.0 False True 33382546.506755643 34488675.63240705 39052021.80402439 1.0 1.0331349534831789 1.1698335175275323 24.992590675608863 -6.944165190964435 0.6196020512456645 0.9985034653677698 1.2117021236053074 0.9986601417450756 0.002690603434842518 0.08591674783740441 0.04633491709450411 0.002710627407148909 0.011567113147967337 1.1371946530809784e-07 6.944165190964435 0.21319865823753759 HYGGLTGLNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYGGLTGLNK 10 0 P18669;P15259;Q8N0Y7 P18669 PGAM1;PGAM2;PGAM4 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2;Probable phosphoglycerate mutase 4 0 334008000.0 106260000.0 146630000.0 81118000.0 False True 161204188.6465687 120462730.87458095 65084991.74471758 1.0 0.7472679952422878 0.40374255961433386 27.264313989696316 -6.966842942833793 0.3248724758373021 1.0444352181117575 0.09541507841471185 0.9999462483941399 0.0017915276630542129 0.07734102878793737 0.012683929044533351 0.005108308071011382 0.030090177734419167 1.0793369803756636e-07 6.966842942833793 -0.9490201396970457 down HYGGLTGLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYGGLTGLNK 10 0 P18669;P15259;Q8N0Y7 P18669 PGAM1;PGAM2;PGAM4 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2;Probable phosphoglycerate mutase 4 0 122329000.0 30516000.0 46169000.0 45644000.0 False True 41798589.863892 44129100.91953366 34863827.26768779 1.0 1.0557557339429504 0.8340909916151298 25.316950935927114 -6.840071593039521 1.2821277280017274 1.0296598306195976 0.8267928491803646 0.9245675154364885 0.025856937240539075 0.16871488289803255 0.5387195895959386 0.015813854137784238 0.036431418947057634 1.445201510989382e-07 6.840071593039521 -0.2028669814392331 HYGGLTGLNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYGGLTGLNK 10 0 P18669;P15259;Q8N0Y7 P18669 PGAM1;PGAM2;PGAM4 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2;Probable phosphoglycerate mutase 4 0 108991000.0 34477000.0 48886000.0 25628000.0 False True 28669153.0900708 48622641.41488872 30986696.309516307 1.0 1.695991550993132 1.0808375194120456 24.77299595104314 -10.353665486301324 4.838984861227713 0.9997104706827258 1.3884145352027766 0.3470759913328817 0.25113558176557915 0.000785010787871856 0.00010485228112906353 0.24333966829688092 0.08105366048475778 4.429294057223499e-11 10.353665486301324 0.3887040645200508 HYGGLTGLNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYGGLTGLNK 10 0 P18669;P15259;Q8N0Y7 P18669 PGAM1;PGAM2;PGAM4 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2;Probable phosphoglycerate mutase 4 0 291918000.0 106260000.0 91873000.0 93785000.0 False True 137555664.6977442 86760186.78714235 76717092.31536302 1.0 0.6307278364564884 0.5577167067887472 27.035440311788765 -13.999999999999998 0.2278844389167885 3.3085143846268417 0.5214958896892337 0.9995069782260269 0.004298571194538097 13.22624127432613 0.1511661114852436 13.799021527554231 0.03840436153622984 1.0000000000000041e-14 13.999999999999998 -2.787018494937608 HYGNKPIGMGGTFIIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYGNKPIGMGGTFIIQK 17 1 A0A1W2PRB8;Q9H0W9;Q9H0W9-2;E9PQS1;A0A087WT99;E9PPB5;E9PJU8;Q9H0W9-4 A0A1W2PRB8 C11orf54 Ester hydrolase C11orf54 0 17292000.0 5551300.0 7481700.0 4259000.0 False True 7277808.058865675 6365459.523438189 3818319.5352127966 1.0 0.8746396541310152 0.5246524096718104 22.795072572114886 -6.953055396400451 0.524231820663174 1.0057585974761423 0.37780147544890796 0.9994197421139044 0.004845471557678138 0.0822816136121683 0.031061043739950573 0.00545304666294929 0.02892195828217346 1.1141524088996294e-07 6.953055396400451 -0.6279571220272343 HYGNKPIGMGGTFIIQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYGNKPIGMGGTFIIQK 17 1 A0A1W2PRB8;Q9H0W9;Q9H0W9-2;E9PQS1;A0A087WT99;E9PPB5;E9PJU8;Q9H0W9-4 A0A1W2PRB8 C11orf54 Ester hydrolase C11orf54 0 5857300.0 2259200.0 2220800.0 1377300.0 False True 1878624.8995297719 2208836.109605714 1665287.062084315 1.0 1.1757728273263044 0.8864393645059979 20.841245605422085 -6.742241070808056 1.6782872553318737 1.1043105441092051 0.8861785340747441 0.6150440023122778 0.07384983478773632 0.31377820726333844 1.736148448047473 0.03479741635509607 0.08518731041358073 1.810334922008121e-07 6.742241070808056 -0.21813201003446103 HYGPGWVSMANAGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 HYGPGWVSMANAGK 14 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 2348109000.0 697760800.0 738602900.0 911745300.0 False True 914771165.9251989 628406226.371555 817406642.4344789 1.0 0.6869545628233541 0.8935640659462133 29.76883565104839 -10.323914204372574 4.9197065825606785 1.0000989770772606 0.7902593155555602 0.5787794291045938 0.08434797644381153 9.161335243752128e-05 1.258995971697544e-05 0.08170801400637223 0.027223192337719686 4.74335681840834e-11 10.323914204372574 -0.20983966152170042 HYGPGWVSMANAGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 HYGPGWVSMANAGK 14 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 1867236200.0 666565100.0 568486200.0 632184900.0 False True 645405355.7597883 795485704.276369 466596709.5495264 1.0 1.2325365712837975 0.7229514062526432 29.265630308872975 -6.782621139674161 1.525470729202469 1.1312207669705312 0.7185649605950444 0.7766028256169477 0.098453590900468 0.24653049153136766 1.1332637731403024 0.05082236193097247 0.11966885261187568 1.6496008067168753e-07 6.782621139674161 -0.4126558063754868 HYGPGWVSMANAGK ddPTM_RPMI8226_Bortezomib_8h_R1 2 HYGPGWVSMANAGK 14 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 4000357500.0 1500530400.0 1353201700.0 1146625400.0 False True 2276414320.266433 1111712284.0218596 919994387.1062334 1.0 0.4883611362503396 0.40414189056698463 31.08411601417671 -13.999999999999998 0.2538845882164193 4.6290504658437355 0.37150831032217735 0.999550125139454 0.005584531876677275 14.155399058703273 0.15943921941714057 26.25926601929263 0.03804504945255348 1.0000000000000041e-14 13.999999999999998 -4.257542155521558 HYGPGWVSMANAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 HYGPGWVSMANAGK 14 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 2619174100.0 697760800.0 910733900.0 1010679400.0 False True 955741824.0366087 870494664.9037333 771977741.3156238 1.0 0.9108052436453695 0.8077262309764253 29.832045712571283 -6.969228778853844 0.2759862012880138 1.023834686221629 0.6915728637792129 0.999975720968416 0.0003870694477940169 0.07655377644654059 0.009922541070774664 0.0019491116819201693 0.009510260395375303 1.0734238022045018e-07 6.969228778853844 -0.3322618224424161 HYGPGWVSMANAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 HYGPGWVSMANAGK 14 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 1638720200.0 666565100.0 543600900.0 428554200.0 False True 554278414.490772 540672414.05537 518162901.80925995 1.0 0.9754527687175006 0.9348422891144116 29.04603558430725 -6.963584805430355 0.38166937620479274 1.0027377309371097 0.906117686165535 0.9998807241198839 0.0002933848054685664 0.0784457951354437 0.016581913476685736 0.0005276311782003553 0.003428786591395618 1.0874647657815944e-07 6.963584805430355 -0.09662004477157471 HYGPGWVSMANAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 HYGPGWVSMANAGK 14 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 4061966800.0 1500530400.0 1253810400.0 1307626000.0 False True 1942466182.67619 1184034749.052079 1069651485.3757929 1.0 0.6095523101569785 0.5506667219823123 30.85524233626916 -13.999999999999998 0.2663503970303223 3.9554330379612614 0.5304185375733635 0.9995755421013619 0.004107960859584587 14.707297595423013 0.16334549585153943 23.484797589153956 0.024910774323385107 1.0000000000000041e-14 13.999999999999998 -3.425014500387898 HYGVYSCEGCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYGVYSCEGCK 11 0 A0A0G2JKR7;P28702;P28702-3;A0A087WZ88;A0A5F9ZHH6;P19793-2;P19793;P48443 A0A0G2JKR7 RXRB;RXRG;RXRA Retinoic acid receptor RXR-beta;Retinoic acid receptor RXR-alpha;Retinoic acid receptor RXR-gamma 0 6015400.0 1917400.0 2512000.0 1586000.0 False True 2908835.980716457 2063713.973654417 1272526.4048315047 1.0 0.7094638499163904 0.4374692878070343 21.47201051943093 -6.993503776782967 0.20919427510331995 1.1451813738857193 8.97480493317632e-11 0.9999938190034467 0.0005710265363489576 0.07351694280942284 0.006753077618789794 0.008182140762007874 0.02762912048167101 1.0150705391112517e-07 6.993503776782967 -1.1451813737959713 down HYGVYSCEGCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYGVYSCEGCK 11 0 A0A0G2JKR7;P28702;P28702-3;A0A087WZ88;A0A5F9ZHH6;P19793-2;P19793;P48443 A0A0G2JKR7 RXRB;RXRG;RXRA Retinoic acid receptor RXR-beta;Retinoic acid receptor RXR-alpha;Retinoic acid receptor RXR-gamma 0 2400220.0 645250.0 898220.0 856750.0 False True 883816.3622255973 858533.6703836687 654403.29532012 1.0 0.9713937273369069 0.7404290340045564 19.753387114609822 -6.929924830708754 0.747407522395593 1.003522088990005 0.6931036086437787 0.996523462958833 0.0068519124870029206 0.09267691796439194 0.0778711850401655 0.006239628155410393 0.02090697556718622 1.175100928142877e-07 6.929924830708754 -0.3104184803462262 HYGVYSCEGCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYGVYSCEGCK 11 0 A0A0G2JKR7;P28702;P28702-3;A0A087WZ88;A0A5F9ZHH6;P19793-2;P19793;P48443 A0A0G2JKR7 RXRB;RXRG;RXRA Retinoic acid receptor RXR-beta;Retinoic acid receptor RXR-alpha;Retinoic acid receptor RXR-gamma 0 4381050.0 1917400.0 954650.0 1509000.0 False True 2482112.097604505 901522.8882952065 1234377.4836475195 1.0 0.3632079667817056 0.4973093217017965 21.24313684152338 -9.88807423616535 6.789820994036896 1.0000000160657456 0.4302586442433764 0.9601074365821987 0.0547466488950501 1.3340375941072766e-08 2.094003953072034e-09 0.05300821643754729 0.01766940495259426 1.2939746368766823e-10 9.88807423616535 -0.5697413718223692 HYGYNSYSVSNSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYGYNSYSVSNSEK 14 0 P07858 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 82281340.0 31834000.0 20151340.0 30296000.0 False True 41734682.28089451 17144838.621308092 27161260.539752677 1.0 0.410805538326974 0.6508078905919138 25.31474345216198 -10.29239845085645 5.690267216211211 1.0000441478838427 0.5308067144594484 0.8359522887281661 0.09798055001948484 5.488140455067792e-05 6.8245519121184e-06 0.09487815373794058 0.03162308653980644 5.100368432753947e-11 10.29239845085645 -0.4692374334243943 HYGYNSYSVSNSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HYGYNSYSVSNSEK 14 0 P07858 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 87457200.0 24026600.0 19926600.0 43504000.0 False True 23263888.73449591 27883395.29584621 32108997.30797528 1.0 1.1985698355967656 1.3802076546370237 24.471588938539778 -6.9721900907516705 0.1990432279284388 0.8905410376556684 1.6932462711402154 0.9999948028206379 0.00035392791081210746 0.0755982388107087 0.006419273194920575 0.005943882517741614 0.019329998967657056 1.0661293741232378e-07 6.9721900907516705 0.802705233484547 HYGYNSYSVSNSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYGYNSYSVSNSEK 14 0 P07858 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 155622000.0 52335000.0 65472000.0 37815000.0 False True 79396021.20099916 53788010.06492919 30340848.675096728 1.0 0.6774648055569351 0.3821457072550999 26.242563375138776 -7.26605083340874 0.23050791488796957 1.1375994231859272 8.477684446566831e-15 0.9999661168638917 0.0014687209498831716 0.10109245654589119 0.01347207540550433 0.015290091830628709 0.04410935760980601 5.419374538589829e-08 7.26605083340874 -1.1375994231859188 down HYGYNSYSVSNSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYGYNSYSVSNSEK 14 0 P07858 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 89449000.0 31834000.0 18683000.0 38932000.0 False True 43603890.08150271 17857523.283580933 29737063.42970865 1.0 0.4095396821293315 0.6819818913891691 25.377953513684872 -10.43496614322181 6.112936828117222 1.000159686554633 0.5457607867592665 0.7875260338074784 0.11122406618052695 0.00024214150037536194 2.2381654537868212e-05 0.10772954908584144 0.03589741300122102 3.673109342491822e-11 10.43496614322181 -0.4543988997953664 HYGYNSYSVSNSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYGYNSYSVSNSEK 14 0 P07858 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 79562700.0 24026600.0 37627000.0 17909100.0 False True 19979182.458853595 37424295.88262527 21653810.007677484 1.0 1.8731645281131624 1.0838186223221458 24.251994213974054 -10.228036702872549 4.313043334665621 0.9997794158638528 1.4784915752317767 0.3288369669373694 0.32224911667808787 227156831.61714613 201.30112117334082 505458.5591847125 0.11031444395487174 5.915116425344622e-11 10.228036702872549 0.4787121593679239 HYGYNSYSVSNSEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYGYNSYSVSNSEK 14 0 P07858 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 115753000.0 52335000.0 43806000.0 19612000.0 False True 67748689.17707926 41368157.591431186 16042817.23611344 1.0 0.6106119261334264 0.23679893192001486 26.013689697231225 -7.609966617700013 0.32568291953291173 1.0775753467484184 1.850002859789145e-12 0.9994221360410878 0.007490419872373111 0.12493584151273839 0.041697988489344966 0.0271431164606729 0.07224210427095103 2.4548976055768662e-08 7.609966617700013 -1.0775753467465683 down HYIFNPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYIFNPR 7 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 7659800.0 1872800.0 2751500.0 3035500.0 False True 2455258.936220999 2340986.9252629965 2721415.578572067 1.0 0.9534582649217912 1.1084026773814424 21.22744375121761 -6.826165664830539 1.3448957124258991 0.975057621523736 1.1122565950874628 0.8979971903965596 0.02073231730087815 0.18559092237043384 0.6578386358620357 0.012108011981451866 0.027873289384807765 1.4922250807449575e-07 6.826165664830539 0.1371989735637268 HYIFNPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYIFNPR 7 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 15964100.0 4220100.0 7105500.0 4638500.0 False True 6402200.230636039 5837468.009475101 3721698.4418732305 1.0 0.9117909154951822 0.5813155333792944 22.610136367611656 -6.946380187360657 0.5972636550842008 1.0037458527917689 0.47252274609743594 0.998885731467358 0.006015636337362862 0.08497266565814843 0.04223479456578948 0.006190873479487713 0.027747834123999424 1.1314094781684745e-07 6.946380187360657 -0.5312231066943329 HYIFNPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYIFNPR 7 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 6911800.0 1872800.0 2465700.0 2573300.0 False True 2565224.770517004 2356757.2210204727 1965539.5387770776 1.0 0.9187332229547603 0.7662250736729538 21.2906538127405 -6.961270755603353 0.41713989201172963 1.0069523283637323 0.672279888511604 0.9998144569603942 0.001319959444550654 0.0792502935407643 0.019476993674917457 0.001969520256246978 0.012705430649209154 1.0932745650565823e-07 6.961270755603353 -0.33467243985212825 HYIFNPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYIFNPR 7 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 5177100.0 1247600.0 2578600.0 1350900.0 False True 1037434.6780512328 2564708.5699879746 1633366.9441441216 1.0 2.472163909929873 1.5744287121887197 19.984589069525057 -10.33845594499871 5.304445951774819 0.9996831332104678 2.0232963110593434 0.6340197021345283 0.3664988597672286 0.001373785144192247 0.00017133275502841713 0.3549654810696758 0.11828699835684986 4.587161757855747e-11 10.33845594499871 1.0236131778488757 HYIFNPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYIFNPR 7 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 13311600.0 4220100.0 3972000.0 5119500.0 False True 5463002.640607483 3750954.708331385 4187803.5305059473 1.0 0.6866104512653651 0.7665754175876192 22.381262689704105 -10.442506103848249 5.893547735293223 1.0001416422590212 0.7265929344264925 0.9397113186739544 0.03264556079806104 6.078815527282329e-05 5.750150331808463e-06 0.031625186540118796 0.01053630944154095 3.6098893998478167e-11 10.442506103848249 -0.2735487078325287 HYILNGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYILNGSK 8 0 Q9H845 Q9H845 ACAD9 Acyl-CoA dehydrogenase family member 9, mitochondrial 0 4291900.0 1911600.0 1236300.0 1144000.0 False True 2474603.883269414 1167498.8182049575 935803.7384312542 1.0 0.47179220322828946 0.37816304450103855 21.238766176787436 -13.999999999999998 0.24336437125137603 4.554099334115694 0.3380663109125373 0.9995306731792263 0.00593050202483281 13.744633557185916 0.15612188836546617 23.786933404161157 0.0448636264402795 1.0000000000000041e-14 13.999999999999998 -4.216033023203157 HYLDFINHYANLFHEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYLDFINHYANLFHEK 16 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y6H2;A0A2R8YFZ7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 43559400.0 13701800.0 19555600.0 10302000.0 False True 17963192.48841994 16637980.707131779 9236047.863761963 1.0 0.9262262661749873 0.5141651668942493 24.09854043845029 -6.937368331090683 0.6836055475459689 1.0049029569113022 0.4111502731733846 0.9977985233276546 0.010029989984051807 0.08898794607880259 0.060231826786463584 0.009578756542776614 0.03589578059011303 1.1551321432617944e-07 6.937368331090683 -0.5937526837379176 HYLDFINHYANLFHEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HYLDFINHYANLFHEK 16 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y6H2;A0A2R8YFZ7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 357292400.0 119783000.0 82197400.0 155312000.0 False True 115980554.23089932 115019250.47377823 114631127.9398734 1.0 0.9917115091965565 0.9883650642991461 26.789307696638243 -13.999999456612441 0.12493353040298137 1.0394044110456648 0.9833624443502523 0.9996677220103829 8.896279936530376e-05 11.94751176077066 0.10938428342070115 0.11619253197138024 0.004442293563895875 1.0000012511968756e-14 13.999999456612441 -0.056041966695412504 HYLDFINHYANLFHEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYLDFINHYANLFHEK 16 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y6H2;A0A2R8YFZ7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 220044300.0 62271400.0 70545900.0 87227000.0 False True 94470266.44914314 57956432.96736756 69986545.21704768 1.0 0.6134886154742419 0.74083145785054 26.493356991468314 -10.910101548892282 11.074797253184993 1.032612205472537 0.677160036662391 0.895503217304279 0.05198749770293287 0.02725840529101678 0.00022126669930740137 0.03277691429734406 0.01677889273453794 1.2299811368887008e-11 10.910101548892282 -0.3554521688101461 HYLDFINHYANLFHEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYLDFINHYANLFHEK 16 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y6H2;A0A2R8YFZ7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 191587400.0 13701800.0 80701700.0 97183900.0 False True 18767725.73722227 77136032.04916582 74231064.38524775 1.0 4.110036193473402 3.955250914500756 24.16175049997318 -10.136353987433079 4.453177495287528 0.9995687443952342 4.032643554102841 0.9980500200195646 0.06319082591233885 11036149.982388739 42.072504067482 48927.78388635447 0.021631900430297425 7.305433849218634e-11 10.136353987433079 3.033074809707607 HYLDFINHYANLFHEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYLDFINHYANLFHEK 16 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y6H2;A0A2R8YFZ7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 378591000.0 119783000.0 113082000.0 145726000.0 False True 99604871.78663903 112472804.82098038 176196632.83910453 1.0 1.1291897956749084 1.7689559725204074 26.56971297207252 -6.9400206416567425 0.6593775927355925 0.9928214122209286 1.9415818439843344 0.9981665294001877 0.014395833122357184 0.08775731863573896 0.05456806049943732 0.01401540904980019 0.05505841944521591 1.1480990520037777e-07 6.9400206416567425 0.9487604317634059 HYLDFINHYANLFHEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYLDFINHYANLFHEK 16 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y6H2;A0A2R8YFZ7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 173155200.0 62271400.0 66940800.0 43943000.0 False True 80611554.85280555 63215485.6343076 35945824.89325574 1.0 0.7841988130577224 0.44591404990130523 26.264483313560763 -6.964514633756704 0.36628839264306057 1.0271339851193642 0.19127205208432138 0.999902785415075 0.002248403706518116 0.07812607450628858 0.015443153627209997 0.004485625402022673 0.028788821344733442 1.0851389847485967e-07 6.964514633756704 -0.8358619330350427 down HYLFYDGESVSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYLFYDGESVSGK 13 0 O75436;S4R3Q6;O75436-2;S4R2Y3 O75436 VPS26A Vacuolar protein sorting-associated protein 26A 0 15308800.0 3777600.0 5431600.0 6099600.0 False True 4952470.182330442 4621226.452210968 5468471.903494713 1.0 0.9331154519008931 1.1041907779687956 22.23971685833424 -6.800652542156415 1.4531437546088972 0.9631277514904035 1.1065935525367914 0.834103994569415 0.028671128882301528 0.21981974871997192 0.9163159275672502 0.015521062705694371 0.03608367843230518 1.582513624941666e-07 6.800652542156415 0.14346580104638784 HYLFYDGESVSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HYLFYDGESVSGK 13 0 O75436;S4R3Q6;O75436-2;S4R2Y3 O75436 VPS26A Vacuolar protein sorting-associated protein 26A 0 8822400.0 2208300.0 2645600.0 3968500.0 False True 2138198.7252623085 3702001.8766217395 2929030.797551946 1.0 1.7313647384050272 1.3698590140131246 21.02796451341485 -10.06699419521734 4.388880827433631 0.9999610037350326 1.550611875824642 0.7556887647644155 0.14758409419770854 103205030.61723682 136843984.00550032 58612.64108779413 0.05401024427703431 8.570493004799239e-11 10.06699419521734 0.5506508720896095 HYLFYDGESVSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYLFYDGESVSGK 13 0 O75436;S4R3Q6;O75436-2;S4R2Y3 O75436 VPS26A Vacuolar protein sorting-associated protein 26A 0 24075000.0 10158000.0 13917000.0 0.0 False True 15410428.649273891 11433402.6159827 0.0 1.0 0.7419263199094348 0.0 23.87740365595268 -7.348740519505808 0.7888904145762629 0.9894335231398832 8.962714351569629e-23 0.9878326714419385 0.04675617574182484 0.10876755541990325 0.13788658605348855 0.04014672122508551 0.07146529527047904 4.479808820214075e-08 7.348740519505808 -0.9894335231398832 down HYLFYDGESVSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYLFYDGESVSGK 13 0 O75436;S4R3Q6;O75436-2;S4R2Y3 O75436 VPS26A Vacuolar protein sorting-associated protein 26A 0 19150500.0 3777600.0 8916100.0 6456800.0 False True 5174280.805801496 8522157.220400153 4931836.821970173 1.0 1.6470225602841186 0.9531444092559703 22.302926919857132 -6.661865287005839 1.9660347927893829 1.4158308175369518 0.9560115209560813 0.24368308644763725 0.2753634266532569 0.4800227945352367 3.5686517205114647 0.1130741888506492 0.30536657698913405 2.178385376856723e-07 6.661865287005839 -0.4598192965808705 HYLFYDGESVSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYLFYDGESVSGK 13 0 O75436;S4R3Q6;O75436-2;S4R2Y3 O75436 VPS26A Vacuolar protein sorting-associated protein 26A 0 7728200.0 2208300.0 3917200.0 1602700.0 False True 1836299.2942774442 3896097.2660966753 1937817.1599524668 1.0 2.1217114651398536 1.0552839430867222 20.808369788849127 -6.634269209027431 2.0646459543157567 1.7366694985764477 1.0596095036200865 0.13320191089881483 0.4806324227040221 0.5479588431257914 4.456660790485095 0.1900203031043378 0.5324359344649242 2.3212974321122638e-07 6.634269209027431 -0.6770599949563612 HYLLAAVNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYLLAAVNR 9 0 E9PKV8;Q8N5M4;H0YDR3 E9PKV8 TTC9C Tetratricopeptide repeat protein 9C 0 19067300.0 5526500.0 6279200.0 7261600.0 False True 7245295.01870213 5342367.836129891 6510239.290185773 1.0 0.7373568394854519 0.8985471638326703 22.7886130049108 -10.352430730272074 5.468407866210472 1.000052361347758 0.817952001906103 0.6297282571896379 0.06580567435407764 4.202077764231824e-05 4.976040271941487e-06 0.06373436908410099 0.02123869007160612 4.441905038536843e-11 10.352430730272074 -0.18210035944165515 HYLLAAVNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYLLAAVNR 9 0 E9PKV8;Q8N5M4;H0YDR3 E9PKV8 TTC9C Tetratricopeptide repeat protein 9C 0 16933100.0 6393500.0 5191500.0 5348100.0 False True 9699406.927459411 4265036.2636253685 4291045.690844498 1.0 0.43972134538977625 0.4424028935930479 23.209465105389786 -10.19470620301862 8.062502934533818 1.0000001797545712 0.4410621194914224 0.9999827372502709 0.0010947374697820968 3.537873662214753e-09 3.526294952501574e-10 0.0010599753447088488 0.0003533249990779447 6.386954127647786e-11 10.19470620301862 -0.5589380602631489 HYLLAAVNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYLLAAVNR 9 0 E9PKV8;Q8N5M4;H0YDR3 E9PKV8 TTC9C Tetratricopeptide repeat protein 9C 0 17223200.0 5526500.0 4477600.0 7219100.0 False True 7569796.398046894 4279764.826556865 5514097.262031489 1.0 0.565373835901465 0.7284340254454132 22.851823066433692 -10.064975837085127 4.952467400804205 1.0000082644926396 0.6469039306709686 0.8621096448442382 0.06656904363258304 6.074654670567964e-06 1.1469859404899243e-06 0.06445670764716066 0.02148506644560726 8.610416567709102e-11 10.064975837085127 -0.35310433382167095 HYLLAAVNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYLLAAVNR 9 0 E9PKV8;Q8N5M4;H0YDR3 E9PKV8 TTC9C Tetratricopeptide repeat protein 9C 0 11468300.0 4080000.0 4820700.0 2567600.0 False True 3392700.774646542 4794729.932265965 3104473.2887589405 1.0 1.413248692044022 0.9150448256322783 21.694002763897124 -6.686501287485951 1.8789553859793264 1.2599301543647052 0.91684179701876 0.35401886145250405 0.17490203178509967 0.4242522477773441 2.901201211478367 0.07454519280475294 0.1949736004351151 2.0582527887480232e-07 6.686501287485951 -0.3430883573459452 HYLLAAVNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYLLAAVNR 9 0 E9PKV8;Q8N5M4;H0YDR3 E9PKV8 TTC9C Tetratricopeptide repeat protein 9C 0 19834400.0 6393500.0 7130000.0 6310900.0 False True 8276511.784726404 6733209.232226272 5162380.955302272 1.0 0.813532247323303 0.6237387307088725 22.980591427482235 -6.970904890227524 0.23557503806939992 1.072001022528168 0.3598102584120962 0.9999886038274007 0.0005185279085323918 0.07601018510780372 0.007972007163259522 0.0046824722323222925 0.01865213050337795 1.06928902610913e-07 6.970904890227524 -0.7121907641160719 HYLPVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYLPVK 6 0 P07686 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 4336500.0 1393400.0 1467500.0 1475600.0 False True 1826760.893704793 1248554.7202701964 1322919.066954685 1.0 0.6834801010755405 0.7241884099411154 20.800856380059557 -10.622853483168523 9.914351496668994 1.0000539972560787 0.7038342555921542 0.9860283661283329 0.0166190975020459 1.9839197278480882e-05 7.546815133524536e-07 0.01609428134891323 0.0053637906545350835 2.383123322044889e-11 10.622853483168523 -0.2962197416639245 HYLPVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYLPVK 6 0 P07686 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 9182300.0 3546100.0 3166900.0 2469300.0 False True 5379692.954635775 2601741.9518973646 1981241.7726673645 1.0 0.4836227594839587 0.3682815709696023 22.359092402800243 -13.999999999999913 0.21062716617825133 3.9941181563785673 0.3007572777483953 0.9994903728262066 0.006200764521428125 12.76142860250091 0.14546056796190462 15.817107263816455 0.06802338444877555 1.0000000000002004e-14 13.999999999999913 -3.693360878630172 HYLPVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYLPVK 6 0 P07686 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 4799600.0 1393400.0 1863400.0 1542800.0 False True 1908577.6352191318 1781068.826560228 1178422.4149633856 1.0 0.9331917097287666 0.6174348861779919 20.864066441582448 -6.941068972919689 0.6495475598428071 1.0034892902609795 0.5295405760206406 0.9983005222427148 0.006877951106583144 0.08728248468462609 0.05241516116497738 0.006750660855753485 0.027051151285409882 1.1453310300887016e-07 6.941068972919689 -0.4739487142403389 HYLPVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYLPVK 6 0 P07686 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 2938810.0 930600.0 1346200.0 662010.0 False True 773835.1325701162 1338947.7534002229 800433.2302116005 1.0 1.7302752188999413 1.0343717886691766 19.561666703908152 -10.249077074997375 5.010335061672889 0.9999339222056961 1.3823235037848014 0.2869577889591971 0.28410138572048893 0.00020973546277604224 3.143408621296405e-05 0.27512736531002885 0.09169332796070492 5.6353763494614856e-11 10.249077074997375 0.3823895815791053 HYNGEAYEDDEHHPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYNGEAYEDDEHHPR 15 0 P31689 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 8700000.0 1225300.0 4512000.0 2962700.0 False True 1606380.165822081 3838827.1876382437 2656148.224225158 1.0 2.3897376656625275 1.6534991409495197 20.61538193069837 -10.084512490291026 4.861252718469995 0.9999707940578573 2.021618403302114 0.7196770849593683 0.3005681191456328 0.00011797152615313728 2.221686886313876e-05 0.2910340975622846 0.0970079434714196 8.231661623567653e-11 10.084512490291026 1.0216476092442568 HYNGEAYEDDEHHPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HYNGEAYEDDEHHPR 15 0 P31689 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 7718000.0 1885700.0 1539500.0 4292800.0 False True 1825839.485679992 2154230.3783864393 3168386.8987604827 1.0 1.1798574821510914 1.7353041839712924 20.80012850913028 -6.950796973754915 0.5500243478678072 0.9923194504595083 1.94893738807372 0.9992623527022487 0.008500109613626254 0.08316728676576814 0.03465005117772191 0.009225527262618759 0.04607921892793488 1.1199613264574514e-07 6.950796973754915 0.9566179376142117 HYNGEAYEDDEHHPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYNGEAYEDDEHHPR 15 0 P31689 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 11525900.0 1225300.0 5186900.0 5113700.0 False True 1678326.522487446 4957725.607215433 3905949.379957393 1.0 2.953969648211001 2.327288121603649 20.67859199222126 -10.095686251783567 5.242688824683765 0.9999702165658892 2.6406288849093 0.9013641844978224 0.2558416619096363 8.906543762128933e-05 1.5362205863441087e-05 0.2477220870479497 0.08257254131917642 8.022574304986636e-11 10.095686251783567 1.6406586683434108 HYNGEAYEDDEHHPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYNGEAYEDDEHHPR 15 0 P31689 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 3808820.0 1885700.0 1206400.0 716720.0 False True 1568043.1006742604 1199900.8837483502 866582.8382611411 1.0 0.7652218763836219 0.5526524353115737 20.580533784564555 -6.972307550381818 0.19535872650631222 1.1343578916900374 0.17767653467310499 0.9999952303799736 0.0003989736376042764 0.07556081006837147 0.006272282452612878 0.007172432608981567 0.0228390765148786 1.0658410669164938e-07 6.972307550381818 -0.9566813570169325 HYNGEAYEDDEHHPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYNGEAYEDDEHHPR 15 0 P31689 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 8287000.0 2701100.0 2775200.0 2810700.0 False True 3496627.1966410447 2620757.680403135 2299181.440217418 1.0 0.749510180244753 0.6575426292016703 21.73753255631549 -13.999999999999991 0.1392824409855155 2.195809716581775 0.5427380236678961 0.9996058087721924 0.002873189358675363 11.933344073278151 0.11687588108641249 3.879994544735895 0.10258523812276253 1.0000000000000205e-14 13.999999999999991 -1.653071692913879 HYPVFENPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYPVFENPK 9 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISU1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 5041300.0 2150800.0 2890500.0 0.0 False True 2819719.628376829 2459248.667080753 0.0 1.0 0.8721607078702428 0.0 21.427120288381065 -7.149663330289633 0.9381796669852532 0.9942333585198037 6.133937692410614e-21 0.9896821721169199 0.04513541844587788 0.08782668191093326 0.14637891397868893 0.037745906205091634 0.06630816675016453 7.084948042758534e-08 7.149663330289633 -0.9942333585198037 down HYPVFENPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYPVFENPK 9 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISU1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 7840800.0 2150800.0 2815700.0 2874300.0 False True 2946008.8831845224 2691293.0637252494 2195449.538066669 1.0 0.9135386790877782 0.745228417537381 21.490330349903957 -6.96057024184338 0.4273225609278837 1.0068785285659079 0.645462599094247 0.9997907611124712 0.001530165708610567 0.07949806586258912 0.020383404651531933 0.0021893417241370676 0.013983865723432026 1.0950394317512126e-07 6.96057024184338 -0.3614159294716609 HYPVFENPK(ub)QGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYPVFENPKQGK 12 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISU1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 4798910.0 1328300.0 2539300.0 931310.0 True False 1104540.3036674047 2525620.286888415 1126042.6151090842 1.0 2.2865804701762347 1.019467204021696 20.075014631602908 -6.6425793333225105 2.0346011555374535 1.8396613064903016 1.0246978474502806 0.16480905128094803 0.5501274324257647 0.5268670317253873 4.1713211209328325 0.21991866949267502 0.6093921763336186 2.277302205135448e-07 6.6425793333225105 -0.814963459040021 HYQFASGAFLHIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HYQFASGAFLHIK 13 0 Q8WUM4;Q8WUM4-2;A0A3B3IT07;Q8WUM4-3;C9IZF9 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 10087000.0 2603200.0 3030400.0 4453400.0 False True 2520562.840919635 4240454.523327232 3286920.9408637555 1.0 1.6823442980616543 1.304042449369964 21.265314492389155 -10.136662561735031 4.448427748298842 0.9999307166527874 1.4931933737316423 0.6938328538207091 0.15444108307467555 17423409.80374126 39702855.415905155 7088.038523216028 0.05286929420035797 7.300245046265906e-11 10.136662561735031 0.49326265707885486 HYQFASGAFLHIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYQFASGAFLHIK 13 0 Q8WUM4;Q8WUM4-2;A0A3B3IT07;Q8WUM4-3;C9IZF9 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 41183000.0 15295000.0 12688000.0 13200000.0 False True 23203633.214278866 10423727.26820352 10591014.214234482 1.0 0.44922823817905594 0.4564377533651527 24.46784738378145 -10.242100969660907 8.416676413968451 1.000000228627784 0.45283299577258457 0.999869809674971 0.0029432722497972565 1.2625099042916885e-08 1.1402612294413425e-09 0.002849812290682518 0.0009499370339015994 5.7266287640781745e-11 10.242100969660907 -0.5471672328551995 HYQFASGAFLHIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYQFASGAFLHIK 13 0 Q8WUM4;Q8WUM4-2;A0A3B3IT07;Q8WUM4-3;C9IZF9 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 9484800.0 2603200.0 4773900.0 2107700.0 False True 2164676.141313695 4748182.05315504 2548410.3250962836 1.0 2.193483802280683 1.1772709443499982 21.04571976782343 -6.606967924247452 2.1651373353510226 1.799008238679557 1.1808286158569654 0.04096002418775946 0.5149527943964485 0.6211147996443379 5.513106195638533 0.19672058023632272 0.5719231666349027 2.4719067062578797e-07 6.606967924247452 -0.6181796228225915 HYQFASGAFLHIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYQFASGAFLHIK 13 0 Q8WUM4;Q8WUM4-2;A0A3B3IT07;Q8WUM4-3;C9IZF9 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 48294700.0 15295000.0 23000000.0 9999700.0 False True 19799679.00952382 21720029.781375084 8179857.205586544 1.0 1.0969889850702912 0.4131307988201203 24.2389737058739 -6.8709686466609625 1.1290299805662019 1.0551823507610585 0.3723488331657235 0.9656368283330767 0.05600476880112647 0.1359257916819551 0.3232519551380866 0.03847543659325794 0.09124370301363798 1.3459575202437774e-07 6.8709686466609625 -0.6828335175953351 down HYQINQQWER ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYQINQQWER 10 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 56983300.0 19123200.0 18056000.0 19804100.0 False True 25070700.389332246 15362115.181736747 17754961.706341337 1.0 0.6127517358180161 0.7081956798421234 24.579498964894835 -9.85879837696583 6.343757601607202 1.0000000195599141 0.6604737078300102 0.9440492566564903 0.03896482698319433 1.0777458861598172e-08 1.861020974805907e-09 0.03772753374707542 0.01257584383278079 1.384208854588814e-10 9.85879837696583 -0.3395263117299039 HYQINQQWER ddPTM_RPMI8226_Bortezomib_2h_R1 1 HYQINQQWER 10 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 25842000.0 10456100.0 9112000.0 6273900.0 False True 10124176.828879775 12750469.118452255 4630577.377034429 1.0 1.2594079828871454 0.45737816074344445 23.27130127510545 -6.819620409442346 1.3733844757141003 1.1398759764345165 0.4399917238289824 0.8835380787910829 0.11403811601050433 0.1939730939800936 0.7189952272973016 0.06525032524871674 0.15041660320564662 1.514884739150424e-07 6.819620409442346 -0.6998842526055342 down HYQINQQWER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYQINQQWER 10 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 43193100.0 19123200.0 19183300.0 4886600.0 False True 26193563.825048488 18335718.375310082 3732485.722686073 1.0 0.7000085401810016 0.14249629212794465 24.642709026417727 -7.30485110895138 0.5332198635715828 1.0073367762612329 1.30532741899363e-24 0.9980173072220041 0.015820490493229474 0.10027758024888646 0.054696860565117564 0.01643827243454837 0.05781406837746152 4.95620077248402e-08 7.30485110895138 -1.0073367762612329 down HYQINQQWER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYQINQQWER 10 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 37746700.0 10456100.0 20301500.0 6989100.0 False True 8694710.433770036 20192131.789967753 8450488.496052774 1.0 2.322346666260675 0.9719114351676726 23.051706550539727 -6.651024532744528 2.005489303423252 1.857397249619075 0.9776537744018415 0.19804200801607152 0.5642544758686522 0.5059769265647841 3.902085077307222 0.22812362399985672 0.6247837923523365 2.233446054731761e-07 6.651024532744528 -0.8797434752172334 HYQINQQWER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYQINQQWER 10 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 44488000.0 25925100.0 18562900.0 0.0 False True 33560553.01012129 17529858.296899464 0.0 1.0 0.522335203821366 0.0 25.000263152885168 -7.8613108529804085 0.6069946181918048 1.0072670427517503 6.208622788600431e-18 0.9884873354095127 0.043818417025413746 0.11452279266111884 0.15854289010932143 0.043965692547263284 0.07755334938340573 1.3762240626560564e-08 7.8613108529804085 -1.0072670427517503 down HYTFASGSPDNIK(ub)QWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HYTFASGSPDNIKQWK 16 1 O43660-2;O43660;H0YAA2 O43660-2 PLRG1 Pleiotropic regulator 1 1 17995100.0 2873200.0 4643900.0 10478000.0 True False 2781991.8387101665 6498233.487618571 7733497.466737879 1.0 2.3358204712172665 2.7798418956985196 21.407686756900357 -9.936125954253402 0.2759231005522957 1.6109020300524267e-15 2.9777950452470647 0.9989629403460604 0.024358989964572225 1.357115960675072 0.12254304198755647 1.2537513429356069 0.17503600181640466 1.1584413358274058e-10 9.936125954253402 2.977795045247063 HYTFASGSPDNIK(ub)QWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYTFASGSPDNIKQWK 16 1 O43660-2;O43660;H0YAA2 O43660-2 PLRG1 Pleiotropic regulator 1 1 64016000.0 14025000.0 19982000.0 30009000.0 True False 21276950.36484217 16416055.979921404 24077707.99658804 1.0 0.7715417716557322 1.1316334147385059 24.342788047719402 -6.735277545974244 1.7040434098284665 0.8633297994579978 1.1316323295343347 0.5835422302903008 0.09600507468217982 0.3264247522447345 1.8592100463841421 0.04460548648363235 0.11002797808231013 1.839595989192327e-07 6.735277545974244 0.26830253007633686 HYTFASGSPDNIK(ub)QWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYTFASGSPDNIKQWK 16 1 O43660-2;O43660;H0YAA2 O43660-2 PLRG1 Pleiotropic regulator 1 1 15133600.0 2781200.0 4488000.0 7864400.0 True False 3809484.799103955 4289705.320168664 6006990.692402157 1.0 1.1260591776551159 1.5768512040827902 21.861164467820576 -6.94745162381088 0.5861632753543632 0.994726767021013 1.7307174556558913 0.9989857455785236 0.007886189393048111 0.0845256600837606 0.040325402199284766 0.008208591890630756 0.03772242984993283 1.1286216480210109e-07 6.94745162381088 0.7359906886348783 HYTFASGSPDNIK(ub)QWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYTFASGSPDNIKQWK 16 1 O43660-2;O43660;H0YAA2 O43660-2 PLRG1 Pleiotropic regulator 1 1 17653300.0 2873200.0 5949700.0 8830400.0 True False 2389193.1043417784 5917647.785177018 10676795.812843487 1.0 2.4768394712102295 4.468787304567806 21.188092032334634 -6.966962876766965 0.32259448545652064 0.7353767055424527 6.274745419775259 0.9999480757962442 0.01024182182751107 0.07730105968153428 0.012544105197146237 0.02988312524231385 0.17481929126416756 1.0790389538933999e-07 6.966962876766965 5.539368714232807 HYTFASGSPDNIK(ub)QWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYTFASGSPDNIKQWK 16 1 O43660-2;O43660;H0YAA2 O43660-2 PLRG1 Pleiotropic regulator 1 1 67342000.0 14025000.0 11578000.0 41739000.0 True False 18155638.97408117 10933674.122120041 34142930.278306015 1.0 0.6022191858809739 1.880568914542097 24.11391436981185 -6.823104294977926 1.3582648192028022 0.7862349791255666 1.9104048916687975 0.8913842064132043 0.17603807534380705 0.1894902034937108 0.6860366457616183 0.1018200201218476 0.23452176666060506 1.502781032801235e-07 6.823104294977926 1.124169912543231 HYWEVEVGDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYWEVEVGDK 10 0 P14373;A0A140T9V9;H0Y551;A0A140T9B9;A0A140T9N6;Q9HCM9-2;Q9HCM9 P14373 TRIM27;TRIM39 Zinc finger protein RFP;E3 ubiquitin-protein ligase TRIM39 0 2395150.0 1414000.0 981150.0 0.0 False True 1853767.693195479 834766.2444927447 0.0 1.0 0.4503079040361283 0.0 20.82202903180236 -8.092306553868134 0.5638408073997754 1.0196490044389548 1.7487518226319488e-17 0.9903327156125431 0.04020595481028262 0.11544721220127534 0.16866132043670967 0.049000581818248234 0.0748724247422784 8.085249871130198e-09 8.092306553868134 -1.0196490044389548 HYWEVEVGDK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYWEVEVGDKAK 12 1 P14373;A0A140T9V9;H0Y551;A0A140T9B9;A0A140T9N6 P14373 TRIM27 Zinc finger protein RFP 1 9077900.0 4620200.0 4457700.0 0.0 True False 6057126.942080442 3792628.535978507 0.0 1.0 0.6261431487641651 0.0 22.530202216275367 -7.58877963292413 0.6819720188491036 0.9960463287396061 6.998878560387736e-21 0.9871055638110934 0.04684728018684851 0.12109707461798785 0.14608258056792917 0.04225628741958463 0.07698270620500162 2.5776287499989703e-08 7.58877963292413 -0.9960463287396061 down HYWEVEVGDK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 HYWEVEVGDKAK 12 1 P14373;A0A140T9V9;H0Y551;A0A140T9B9;A0A140T9N6 P14373 TRIM27 Zinc finger protein RFP 1 14740100.0 4971300.0 3215000.0 6553800.0 True False 4813488.802652047 4498766.266003512 4837163.170214424 1.0 0.9346165433115509 1.0049183385550484 22.19865150360872 -10.043516096194667 4.381740674847928 1.0000012808557168 0.969767440929678 0.19780441223389844 0.02870058774099352 40060450.15384543 930359733938.4484 3989849.0037435093 0.010533606952092265 9.046569079463464e-11 10.043516096194667 -0.030233839926038786 HYWEVEVGDK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYWEVEVGDKAK 12 1 P14373;A0A140T9V9;H0Y551;A0A140T9B9;A0A140T9N6 P14373 TRIM27 Zinc finger protein RFP 1 9895500.0 4620200.0 3597900.0 1677400.0 True False 6328412.796210303 3438932.881335751 1281232.6671374014 1.0 0.5434115934085584 0.20245718925046305 22.593412277798258 -8.049406905702101 0.30408747274708825 1.125562415991126 6.861673284565924e-21 0.9990933976673105 0.009837913491514616 0.09479714790474293 0.06145654575682185 0.06275742376356491 0.09103682044147036 8.924689065268316e-09 8.049406905702101 -1.125562415991126 down HYWEVEVGDK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYWEVEVGDKAK 12 1 P14373;A0A140T9V9;H0Y551;A0A140T9B9;A0A140T9N6 P14373 TRIM27 Zinc finger protein RFP 1 12168600.0 4971300.0 5877500.0 1319800.0 True False 4133856.2159314677 5845836.740907587 1595764.0779342772 1.0 1.4141364468310045 0.38602312092625823 21.979056779042995 -6.797344818655223 1.466534692677364 1.2292696625967008 0.372710213585702 0.8243601179275268 0.17700869691539256 0.22455652403916954 0.9537020883486175 0.09496241453804033 0.22123336551405862 1.5946125630995765e-07 6.797344818655223 -0.8565594490109988 down HYWEVEVGDK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYWEVEVGDKAK 12 1 P14373;A0A140T9V9;H0Y551;A0A140T9B9;A0A140T9N6 P14373 TRIM27 Zinc finger protein RFP 1 76145000.0 19951000.0 39916000.0 16278000.0 True False 25826962.79300485 37694639.511016004 13315571.026384596 1.0 1.4595072526772475 0.5155685991072506 24.62237465915394 -6.774332911439837 1.5578718633371162 1.2620975959888823 0.5093657768038732 0.7468662695095701 0.19390705636810948 0.25947362667521584 1.2433462128822288 0.09807630545422213 0.23254656296738108 1.6813846898784534e-07 6.774332911439837 -0.7527318191850091 HYYEVSCHDQGLCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYYEVSCHDQGLCR 14 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 63835000.0 15661000.0 30524000.0 17650000.0 False True 23758881.972462934 25076753.714899443 14161469.763730194 1.0 1.0554685925021199 0.5960495018302481 24.50196361269307 -6.876731325677697 1.0979176367727386 1.0330913276512792 0.5654710128860192 0.9709494841060081 0.034898745195631624 0.13056243168674375 0.29014693283979337 0.02455424788068101 0.05891320875547561 1.3282158983877566e-07 6.876731325677697 -0.46762031476526 HYYEVSCHDQGLCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYYEVSCHDQGLCR 14 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 44784000.0 15661000.0 13839000.0 15284000.0 False True 20273473.224462368 13068847.48454131 12502468.827083308 1.0 0.644627950023491 0.6166910173042075 24.27308993478552 -13.999999999996906 0.3605721320958302 5.666376685941443 0.6133546632497056 0.9997743233642907 0.0026211552215678045 21.759033632206123 0.19411297386424894 78.15362087457002 0.008046686169138851 1.0000000000071251e-14 13.999999999996906 -5.053022022691737 HYYSITINYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 HYYSITINYR 10 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 99567400.0 31069500.0 26776800.0 41721100.0 False True 40732415.377465986 22781805.815148916 37404200.78905057 1.0 0.559304072788973 0.9182907628341468 25.27967403096564 -9.95429211918424 6.80026439386578 1.0000000202249473 0.7387974178115585 0.41379570042955593 0.14655570251022837 4.492711435165874e-08 6.840776766608939e-09 0.14190195935096353 0.04730064959281947 1.1109841954055163e-10 9.95429211918424 -0.2612026024133888 HYYSITINYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 HYYSITINYR 10 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 124797300.0 41696600.0 32660100.0 50440600.0 False True 40372964.256564915 45701448.250171445 37228693.67443584 1.0 1.1319814903791734 0.9221194024261472 25.266886180216172 -6.736699752175127 1.6987192187290319 1.0788266584152493 0.9220812749256307 0.5900680894438761 0.05545900071565087 0.32381757080799456 1.833412540041135 0.02584098133358913 0.06364409355508872 1.8335816239085663e-07 6.736699752175127 -0.15674538348961853 HYYSITINYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 HYYSITINYR 10 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 960655000.0 247452000.0 296647000.0 416556000.0 False True 375402775.1644147 243708025.13640997 334223524.0170196 1.0 0.6491907925552054 0.8903064818064814 28.48386407442789 -10.098509411404255 5.271734963040465 1.000004071765466 0.7697486371806108 0.5487128782063261 0.09843506794166296 4.710789141956113e-06 8.055427250752203e-07 0.0953110302908697 0.031769781568287386 7.970592176842253e-11 10.098509411404255 -0.2302554345848551 HYYSITINYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 HYYSITINYR 10 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 92205300.0 31069500.0 26483200.0 34652600.0 False True 42556733.77166704 25313084.655768935 26468369.572699107 1.0 0.5948079754330584 0.6219549111713298 25.342884092488532 -10.727880844629611 6.824686362215397 1.0054417096704122 0.6083814433022254 0.9964090105250984 0.011082690106481658 0.0009236204741688809 3.682726806769159e-05 0.010800883143218818 0.0035769228511317655 1.871195461196878e-11 10.727880844629611 -0.3970602663681868 HYYSITINYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 HYYSITINYR 10 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 84487400.0 41696600.0 22083600.0 20707200.0 False True 34672570.372580186 21964631.26354861 25036979.78072482 1.0 0.6334872502247111 0.7220975979480484 25.04729145565045 -9.769273627566017 5.9070280771252 1.000000017306152 0.6777924240850712 0.9463218512546342 0.0361750229801158 8.254310996420368e-09 1.6788008648038735e-09 0.035026317473352137 0.011675438461874334 1.7010863999192272e-10 9.769273627566017 -0.32220759322108083 HYYSITINYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 HYYSITINYR 10 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 943907000.0 247452000.0 378944000.0 317511000.0 False True 320331492.0081516 357855433.28145254 259727255.93797737 1.0 1.1171409686823612 0.8108077489033392 28.254990396520338 -6.803045211624735 1.4433133651938164 1.0643844551408685 0.8062475314755477 0.8409549221228936 0.05033225950107451 0.21643770520052663 0.8897683667733508 0.02742948123780872 0.06368011011480228 1.5738190156917746e-07 6.803045211624735 -0.2581369236653208 IAAAILNTPDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAAAILNTPDLR 12 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 34154700.0 8527700.0 10991000.0 14636000.0 False True 11179897.282364285 9351185.64258244 13121607.118425542 1.0 0.8364285830544667 1.1736786829986539 23.414403597392244 -6.774816953958228 1.556012716721757 0.9067590363623778 1.1759313205605 0.7486529668953039 0.06903643315859523 0.25870526303719027 1.236760495037375 0.0349584095025847 0.08285345104589545 1.679511748043767e-07 6.774816953958228 0.2691722841981222 IAAAILNTPDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAAAILNTPDLR 12 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 23879300.0 6772200.0 4139100.0 12968000.0 False True 6557220.217914862 5791864.215121345 9571291.768339075 1.0 0.8832804180188273 1.4596569049472403 22.644652916520823 -6.853991451259758 1.2156700156365385 0.9374320887049028 1.4845354295229432 0.9459147670737377 0.057861755673734964 0.15312121759959627 0.43345719935800964 0.03720239081570239 0.08633794365164252 1.3996148726031243e-07 6.853991451259758 0.5471033408180404 IAAAILNTPDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAAAILNTPDLR 12 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 26439100.0 8527700.0 8526700.0 9384700.0 False True 11680621.142427318 8149962.19997375 7168227.143963492 1.0 0.6977336308230033 0.6136854416009149 23.477613658915136 -13.999999999999998 0.17956936990777894 2.5662611631839187 0.5466239432321964 0.9994986627716695 0.0037143099530753906 12.199206557559547 0.13432992378090083 6.665879328716937 0.06298390678669005 1.0000000000000041e-14 13.999999999999998 -2.019637219951722 IAAAILNTPDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAAAILNTPDLR 12 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 13758900.0 6772200.0 4421100.0 2565600.0 False True 5631384.359328757 4397282.656780362 3102055.0980058913 1.0 0.7808528731476081 0.5508512472367711 22.4250581919551 -6.970515590709386 0.24557208356102986 1.0770852405428186 0.24792016136701892 0.9999861250733967 0.00068305657594979 0.07613584761239238 0.008429936506468312 0.005287729809441606 0.022206604358052124 1.070247961459719e-07 6.970515590709386 -0.8291650791757997 IAAIDNGLAFPFK(ub)HPDEWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAAIDNGLAFPFKHPDEWR 19 1 G5E9Z4;Q8TCG2 G5E9Z4 PI4K2B Phosphatidylinositol 4-kinase type 2-beta 1 7142500.0 1254000.0 1587300.0 4301200.0 True False 1214192.456404895 2221117.1676601507 3174586.6867658873 1.0 1.8292958055732458 2.614566307029717 20.21156568440603 -6.9717860275243755 0.21121476290340932 0.5951836046902901 3.8706303016122012 0.9999931647662883 0.00172348821797369 0.07572733191258388 0.0069168173051975266 0.023290019106807763 0.08114597169212923 1.067121751770547e-07 6.9717860275243755 3.275446696921911 IAAIDNGLAFPFK(ub)HPDEWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAAIDNGLAFPFKHPDEWR 19 1 G5E9Z4;Q8TCG2 G5E9Z4 PI4K2B Phosphatidylinositol 4-kinase type 2-beta 1 6384900.0 1254000.0 1729800.0 3401100.0 True False 1042756.5616193047 1720481.224061585 4112254.285090369 1.0 1.6499356488247232 3.9436378886980274 19.991970959840305 -6.947753956796577 0.5829804607244882 0.972877556612654 4.734728554854384 0.9990130333535368 0.039667340450389374 0.0844003731428063 0.03979299165528394 0.04142820621183638 0.19176420760291993 1.1278362343793918e-07 6.947753956796577 3.76185099824173 IAALQAFADQLIAAGHYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAALQAFADQLIAAGHYAK 19 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 25597700.0 5304600.0 12967000.0 7326100.0 False True 8047466.018206186 10652937.538366575 5878093.1238563005 1.0 1.3237629726259048 0.7304278279098037 22.940103149014835 -6.758539865806954 1.6180310984576678 1.1884009393573192 0.7284198363220425 0.6849575424082179 0.136148211563114 0.2853753434534885 1.4721745762978944 0.06640223315269182 0.15980182928341224 1.7436532924892828e-07 6.758539865806954 -0.4599811030352766 IAALQAFADQLIAAGHYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAALQAFADQLIAAGHYAK 19 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 20604900.0 5304600.0 12050000.0 3250300.0 False True 6866909.269298464 11379406.907198705 2658778.7508943235 1.0 1.6571366332267334 0.38718710945862683 22.711229471107284 -6.766061051616771 1.589458893984232 1.3788070990643755 0.3810709716704014 0.7152975672319193 0.27669071011393653 0.2728455940770774 1.3597300538560324 0.13726215586318524 0.3279454158563514 1.7137163822504513e-07 6.766061051616771 -0.9977361273939741 IAAPNMK(ub)AMEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAAPNMKAMEK 11 1 Q14683;G8JLG1;V9GY57 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 6305100.0 2141100.0 1401900.0 2762100.0 True False 2073131.9524788875 1961685.9808119212 2038623.1487761666 1.0 0.9462427022391372 0.9833542656744748 20.983380514584077 -10.065819607272594 4.426314600922574 1.000002369689942 0.9647984839711057 0.5453755679758401 0.015150732339720169 3.857310652586024e-07 8.142348747084472e-08 0.014670708512918995 0.004889877834698039 8.593704037264032e-11 10.065819607272594 -0.03520388571883637 IAAPNMK(ub)AMEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAAPNMKAMEK 11 1 Q14683;G8JLG1;V9GY57 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 3971400.0 1446000.0 1443300.0 1082100.0 True False 1980625.276680687 1379530.2336451497 826530.2665490523 1.0 0.6965124851668523 0.4173077443171014 20.91752452546697 -7.11756496946828 0.21491001911444288 1.1463536133445522 5.0735321780084e-13 0.999989938366565 0.0007547633946404666 0.07858285059043443 0.008303227129336684 0.010122284120022387 0.031374807336062155 7.628427630800317e-08 7.11756496946828 -1.1463536133440448 down IAAQTLLGTAK(ub)MLLHEGQHPAQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAAQTLLGTAKMLLHEGQHPAQLR 24 1 A0A0A0MQS1;Q53H96-2;Q53H96;B5MD87 A0A0A0MQS1 PYCRL Pyrroline-5-carboxylate reductase;Pyrroline-5-carboxylate reductase 3 1 52302700.0 27174000.0 21893000.0 3235700.0 True False 22596385.012314998 21775058.06357974 3912269.9098135605 1.0 0.9636522856072935 0.17313698220672816 24.429588651809535 -6.9165084909469705 0.8502230126158948 1.0197321842327027 0.05536457310994816 0.9931546869912813 0.03156463507407252 0.10027004673685429 0.11658283162321237 0.026704768219310906 0.07750749405493815 1.2119689931824653e-07 6.9165084909469705 -0.9643676111227546 down IAAVHNVPLSVLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAAVHNVPLSVLIR 14 0 Q9BYN0 Q9BYN0 SRXN1 Sulfiredoxin-1 0 5058400.0 1593800.0 1893100.0 1571500.0 False True 2089487.2343811542 1610656.859246002 1408896.2548924412 1.0 0.7708383342782337 0.6742784697173398 20.99471751393747 -13.999999999999998 0.1183131617784947 2.0937248234373014 0.5166011283962574 0.9997012563746689 0.002360996267142664 11.970554603270976 0.10563763867627626 3.085508794911435 0.13991189426130887 1.0000000000000041e-14 13.999999999999998 -1.577123695041044 IAAVHNVPLSVLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAAVHNVPLSVLIR 14 0 Q9BYN0 Q9BYN0 SRXN1 Sulfiredoxin-1 0 8068900.0 2494300.0 2452700.0 3121900.0 False True 2415119.8118107906 3432075.9006615328 2304180.7350075394 1.0 1.4210789393873824 0.9540647729935716 21.203663330897722 -6.669193522451704 1.9403737504510798 1.2689636768883197 0.9559657832723144 0.2753950100453061 0.1788993491982271 0.46298653733348205 3.3599317922974485 0.07424773160700911 0.1985699183099806 2.1419359376857437e-07 6.669193522451704 -0.3129978936160053 IAAVHNVPLSVLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAAVHNVPLSVLIR 14 0 Q9BYN0 Q9BYN0 SRXN1 Sulfiredoxin-1 0 7294000.0 1593800.0 2069700.0 3630500.0 False True 2183070.930825501 1978253.8104173571 2773050.672494532 1.0 0.9061793561005849 1.2702522090960815 21.05792757546036 -6.838315063979593 1.2902371305726152 0.950074056018092 1.2818300524013433 0.9215123599536224 0.04323935636156401 0.17077551899834334 0.5529737220130382 0.02628578005802253 0.06053145162029463 1.4510585483640724e-07 6.838315063979593 0.33175599638325126 IAAYK(ub)SILQER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAAYKSILQER 11 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 13445500.0 2216200.0 4926500.0 6302800.0 True False 2905459.6617113315 4191485.403346596 5650646.716726736 1.0 1.4426238500512474 1.9448374352574818 21.470334994300384 -6.969481300152295 0.2702859175816965 0.8755852202820238 2.526979925587443 0.9999780501859642 0.0018083496177538022 0.07647136325958216 0.009630740226668754 0.009827321392157076 0.04669029306525592 1.0727998394464305e-07 6.969481300152295 1.6513947053054192 IAAYK(ub)SILQER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAAYKSILQER 11 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 33955000.0 5042000.0 11726000.0 17187000.0 True False 4881944.469851264 16408252.950282196 12685209.101052111 1.0 3.361007699209266 2.5983927468635435 22.21902445446253 -10.056340759893262 5.558604809804106 0.999988749531053 2.979700223037256 0.8998516187488557 0.31133625058032166 4.340740946678733e-05 7.370032470135163e-06 0.30145173340542775 0.10048334279691813 8.783330810906191e-11 10.056340759893262 1.9797114735062031 IAAYK(ub)SILQER ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAAYKSILQER 11 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 92476000.0 18678000.0 15171000.0 58627000.0 True False 28335891.544707447 12463616.518435974 47039347.75287302 1.0 0.4398526334973892 1.6600623869079916 24.75612725952622 -6.781882700494903 1.5285065728955214 0.6836078660483071 1.6703111634656296 0.7740101866142891 0.2370762636997268 0.24765699043138542 1.1429677892477907 0.12214720424284237 0.2877693600240229 1.652408040307272e-07 6.781882700494903 0.9867032974173224 IAAYK(ub)SILQER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAAYKSILQER 11 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 32540900.0 2216200.0 3855700.0 26469000.0 True False 3035589.03055307 3685342.4249051567 20217567.346166585 1.0 1.2140452438760148 6.660179340048228 21.533545055823275 -6.915187409882189 0.8596470819835836 0.8577610526223758 7.4480965607372545 0.9927366037336967 0.22322630439539512 0.10108712699261874 0.1208948155594702 0.18758194954575033 0.5384678493699636 1.2156612965257963e-07 6.915187409882189 6.590335508114879 up IAAYK(ub)SILQER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAAYKSILQER 11 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 30282620.0 5042000.0 11188000.0 14052620.0 True False 4192646.3984725187 11127728.023355862 16990957.870026316 1.0 2.654106014618824 4.052561617458732 21.999429729896807 -7.2451865156835105 0.1940240546143268 3.9688937500397836e-19 6.36511551636358 0.9999867329813055 0.004544459420784892 0.10157208541123819 0.010642143588644322 0.09221844480026986 0.2303010369975693 5.6860867903405256e-08 7.2451865156835105 6.36511551636358 IAAYK(ub)SILQER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAAYKSILQER 11 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 93452000.0 18678000.0 18370000.0 56404000.0 True False 24179039.19842339 17347693.351472218 46139050.75391296 1.0 0.7174682670022465 1.9082251521773244 24.52725358161867 -6.844130489224452 1.263156804285155 0.8496873432187243 1.950682141202014 0.931311095947102 0.1331401868427501 0.16403167079536965 0.506618135982937 0.08258972055598564 0.1905261082920566 1.4317576450961152e-07 6.844130489224452 1.1009947979832897 IAAYLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAAYLFK 7 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13;K7EJJ5;J3KRF5 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 17327300.0 5107100.0 3424700.0 8795500.0 False True 6695457.557226748 2913748.1093760408 7885426.032393553 1.0 0.4351828212593304 1.1777277303300073 22.674751219793222 -6.703312732745306 1.818734664630473 0.6504287632621382 1.1756885976317033 0.43350404144485055 0.2382732310721453 0.38864679710529126 2.501476016075941 0.10442051157757977 0.2674812886803638 1.9801006541859178e-07 6.703312732745306 0.5252598343695651 IAAYLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAAYLFK 7 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13;K7EJJ5;J3KRF5 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 5639330.0 1966600.0 920830.0 2751900.0 False True 1904171.359462417 1288522.2210650137 2031094.8347696105 1.0 0.6766839626391542 1.0666554901566352 20.860731884273847 -6.686543194707928 1.8783564940088402 0.7966546348164996 1.0652676353481965 0.35447162799313525 0.13683638560008599 0.42412925677969704 2.8984274669248946 0.058333190028039605 0.15258813904926116 2.058054187341343e-07 6.686543194707928 0.2686130005316969 IAAYLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAAYLFK 7 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13;K7EJJ5;J3KRF5 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 11270600.0 5107100.0 2626000.0 3537500.0 False True 6995332.884188052 2509974.636979263 2702015.3570994106 1.0 0.3588070329937694 0.3862597251385891 22.737961281316114 -10.632135126949455 6.535645181533318 1.0024737530495433 0.37253337906618117 0.9985664034304967 0.011207514636753345 0.0004050063035696135 2.2796131992067836e-05 0.010879295638918322 0.003617209795043466 2.3327321400452784e-11 10.632135126949455 -0.6299403739833622 IAAYLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAAYLFK 7 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13;K7EJJ5;J3KRF5 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 4967700.0 1966600.0 1254000.0 1747100.0 False True 1635315.0351519366 1247244.4531004876 2112410.532322303 1.0 0.7626936867149922 1.2917453132362595 20.641137159708123 -6.784754316863685 1.5170714508211969 0.8664565337170306 1.2965978216411032 0.7839056538808842 0.10057943322856548 0.24327556601941425 1.1060865242543703 0.052199738357292434 0.1227035975246908 1.6415181277779788e-07 6.784754316863685 0.4301412879240726 IACGLGK(ub)SDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IACGLGKSDR 10 1 G3V2R2;G3V2M4;Q9P055-2;Q9P055-3;Q9P055;Q9P055-5 G3V2R2 JKAMP JNK1/MAPK8-associated membrane protein 1 7076670.0 744070.0 2204300.0 4128300.0 True False 963213.2828124459 2081628.7672645708 3376991.7599350954 1.0 2.1611296318365865 3.505964691511271 19.87749576158791 -6.969198144714186 0.27666756699703005 0.6915841429141136 5.016304680082282 0.9999754355343642 0.005075061785286204 0.07656375928504194 0.009957812538276883 0.0253274124321816 0.1239668740626596 1.0734995217354349e-07 6.969198144714186 4.324720537168169 IADFGWSVHAPSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IADFGWSVHAPSLR 14 0 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KT86;Q96GD4-2 Q96GD4-5 AURKB Aurora kinase B 0 9509600.0 2632900.0 3060700.0 3816000.0 False True 3451757.3970398656 2604055.490515159 3421156.92565673 1.0 0.7544144014142845 0.9911348139908738 21.718899639175063 -10.671796567143025 8.722619839889374 1.000174493809301 0.8727746077286235 0.27804960045787974 0.0966407037522929 0.00032838182549956685 1.2355887627772847e-05 0.09369915336297024 0.031190653016532906 2.1291361455031837e-11 10.671796567143025 -0.12739988608067743 IADFGWSVHAPSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IADFGWSVHAPSLR 14 0 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KT86;Q96GD4-2 Q96GD4-5 AURKB Aurora kinase B 0 21392500.0 2999700.0 9243300.0 9149500.0 False True 4550764.207445064 7593760.896767464 7341097.314631695 1.0 1.6686781715352441 1.6131570391235912 22.117677406001082 -10.13702154568464 4.868557526970635 0.9999596965873223 1.6409176053324068 0.9944032481135529 0.022666407401991783 9.91641062006603e-06 1.7577754412801224e-06 0.02194802980484479 0.0073155515307191865 7.294213222018134e-11 10.13702154568464 0.6409579087450845 IADFGWSVHAPSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IADFGWSVHAPSLR 14 0 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KT86;Q96GD4-2 Q96GD4-5 AURKB Aurora kinase B 0 10643300.0 2632900.0 3715200.0 4295200.0 False True 3606354.2814471447 3551050.179476519 3280762.2224207493 1.0 0.9846648172490604 0.9097171177270629 21.782109700697955 -6.940317703034587 0.656627125828316 1.0008369116597648 0.8893175722615617 0.9982048674242956 0.0016712445197375873 0.08762257942164164 0.05395729565554246 0.0016307440942258484 0.006441647569861702 1.1473140103225624e-07 6.940317703034587 -0.11151933939820313 IADFGWSVHAPSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IADFGWSVHAPSLR 14 0 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KT86;Q96GD4-2 Q96GD4-5 AURKB Aurora kinase B 0 16366100.0 2999700.0 7532100.0 5834300.0 False True 3883170.7829270056 7112932.013751977 4772517.264973307 1.0 1.8317329861012408 1.2290258481435992 21.88880372809353 -10.044656987628604 5.443279392962762 0.99999665507627 1.530379417122877 0.5080004491164758 0.24605415872318132 9.988010593863934e-06 1.7531157291702434e-06 0.23824241955579364 0.0794136382497638 9.022834934477513e-11 10.044656987628604 0.5303827620466071 IADFLNSFDMSCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IADFLNSFDMSCR 13 0 Q8WUW1;Q8WUW1-2 Q8WUW1 BRK1 Protein BRICK1 0 3732160.0 825360.0 1579100.0 1327700.0 False True 1082054.9527976091 1343504.4352835887 1190322.3401977054 1.0 1.2416231096304422 1.1000571986849423 20.04534233846618 -10.149477721826607 4.41750740685115 0.9999701187697491 1.1708401541642774 0.6600703951909646 0.05779404115375735 6438636.172659108 14793138.297026241 1091.321192236807 0.019784437707503065 7.087976649888456e-11 10.149477721826607 0.17087003539452839 IADMGHLK(ub)YYLAPK ddPTM_RPMI8226_Bortezomib_1h_R1 2 IADMGHLKYYLAPK 14 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 542804600.0 157758200.0 185109000.0 199937400.0 True False 206822527.93258223 157491458.74923074 179249795.78296652 1.0 0.7614811612812706 0.8666840966250854 27.623818097394338 -10.15641053011309 4.634133489315875 1.000022909392217 0.8140826289509225 0.8063560632628731 0.042948918513605355 10360629.93015873 22706902.06770418 1522.2386531613224 0.01470255591344793 6.975726904444695e-11 10.15641053011309 -0.18594028044129451 IADMGHLK(ub)YYLAPK ddPTM_RPMI8226_Bortezomib_2h_R1 2 IADMGHLKYYLAPK 14 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 469322200.0 125496500.0 165911000.0 177914700.0 True False 121512682.30081107 232160127.5144353 131313502.74340808 1.0 1.9105835137414762 1.0806567697874907 26.85653165513275 -10.231596410032743 4.340718501871274 0.9997710581261081 1.495620141776833 0.3222669539086398 0.3388161744710978 238918247.0171777 221.4858164157325 546703.7146572773 0.11598578849721643 5.866831160248924e-11 10.231596410032743 0.4958490836507248 IADMGHLK(ub)YYLAPK ddPTM_RPMI8226_Bortezomib_8h_R1 2 IADMGHLKYYLAPK 14 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 1661136000.0 320832000.0 518433000.0 821871000.0 True False 486725599.96100074 425914580.6144826 659427836.6111436 1.0 0.875060980249671 1.3548246417775862 28.858533416118227 -6.837540645374845 1.2938008635459906 0.9335002809411074 1.36984841637843 0.9201373610115391 0.057429784556434584 0.17169068241734825 0.5593359980341019 0.034820188843631215 0.08017244504055906 1.4536483331161766e-07 6.837540645374845 0.43634813543732254 IADMGHLK(ub)YYLAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 IADMGHLKYYLAPK 14 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 466323400.0 157758200.0 183474200.0 125091000.0 True False 216085669.79505345 175367703.17595577 95547082.13001359 1.0 0.8115656320119855 0.4421722283603316 27.68702815891723 -6.960434764871174 0.4292621205932899 1.0147882207108374 0.2248012348097552 0.9997859860775863 0.0033894677065076768 0.07954617001791905 0.020560122394575574 0.0048134340130501375 0.030676373613944142 1.0953810795831474e-07 6.960434764871174 -0.7899869859010822 down IADMGHLK(ub)YYLAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IADMGHLKYYLAPK 14 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 597116300.0 125496500.0 286111000.0 185508800.0 True False 104355900.18760544 284569663.2544131 224297832.3842203 1.0 2.726914939575329 2.149354583506919 26.636936930567025 -10.132191222128268 5.161048922582544 0.9999522550234424 2.438134761542772 0.8920891520441596 0.2357880280104414 0.00012956011852672964 2.178529332161678e-05 0.22830828403096667 0.07610025880912483 7.375793985610039e-11 10.132191222128268 1.4381825065193299 IADMGHLK(ub)YYLAPK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IADMGHLKYYLAPK 14 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 1200492000.0 320832000.0 353942000.0 525718000.0 True False 415323348.5441999 334244816.55997676 430042718.3222052 1.0 0.8047821480096862 1.0354407471421965 28.629659738210677 -6.682444473737791 1.893628449954469 0.8767509675742612 1.0345707032245353 0.3351380918137947 0.08269481924682275 0.433126587512068 3.0049845019999744 0.035017816471393313 0.09205450955144184 2.077569334025184e-07 6.682444473737791 0.15781973565027407 IAEFTTNLTEEEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAEFTTNLTEEEEK 14 0 P35579 P35579 MYH9 Myosin-9 0 31482400.0 5264400.0 14519000.0 11699000.0 False True 6901679.380522111 12352821.794618739 10488499.70473221 1.0 1.7898284045881379 1.5197025428814914 22.718516023845982 -10.137993033000274 4.689471261981032 0.9999507861508262 1.654765473653144 0.8867996964955428 0.11027842143353317 6.848212844198795e-05 1.258827957915913e-05 0.10678626126675995 0.03559220744436895 7.277914797539414e-11 10.137993033000274 0.6548146875023179 IAEFTTNLTEEEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAEFTTNLTEEEEK 14 0 P35579 P35579 MYH9 Myosin-9 0 34512400.0 6612300.0 4133100.0 23767000.0 False True 6402396.155890024 5783468.383831764 17541709.70528338 1.0 0.9033287292775746 2.7398663372533583 22.610180517444075 -6.894481751129272 0.9955201561914087 0.911658907276493 2.9124067932782647 0.983614368267955 0.108023278427711 0.1155810816074787 0.20122175023039604 0.08215488644795609 0.20840414354292638 1.2750236747744834e-07 6.894481751129272 2.0007478860017716 up IAEFTTNLTEEEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAEFTTNLTEEEEK 14 0 P35579 P35579 MYH9 Myosin-9 0 30577400.0 5264400.0 12614000.0 12699000.0 False True 7210790.945060711 12056671.771080125 9699757.744114615 1.0 1.6720318010798487 1.3451725085385828 22.781726085368874 -9.99894826384263 4.326163648612579 0.999977030304601 1.508602154576274 0.7634981516330239 0.13343974787020527 92683201.22305602 159077983.07996634 30586.461935161962 0.04883393941137859 1.002424646710755e-10 9.99894826384263 0.5086251242716731 IAEFTTNLTEEEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAEFTTNLTEEEEK 14 0 P35579 P35579 MYH9 Myosin-9 0 12732400.0 6612300.0 3802500.0 2317600.0 False True 5498420.42455768 3782015.177762841 2802199.4446283327 1.0 0.6878366668491133 0.5096371736349636 22.39058579287835 -11.018820086304325 0.0925751872911034 2.003652710749964 1.8594132003620897e-14 0.999917330567457 0.0018426734883928537 3.3751877375818444 0.056524547927100946 1.0473839685804927 0.32778927484586806 9.575906869688962e-12 11.018820086304325 -2.0036527107499453 IAEGEHPK(ub)DIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAEGEHPKDIR 11 1 Q8TCJ2 Q8TCJ2 STT3B Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B 1 14814000.0 0.0 0.0 14814000.0 True False 0.0 0.0 11315238.303906899 0.0 IAEGVNSLLQMAGLLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAEGVNSLLQMAGLLAR 17 0 P35250;P35250-2;A0A087WVY3 P35250 RFC2 Replication factor C subunit 2 0 204781000.0 92542000.0 26999000.0 85240000.0 False True 89604304.86492965 37779841.497925036 62913086.85481353 1.0 0.42162975936116814 0.702121253545232 26.417064709642798 -10.47694342664607 6.249397996701666 1.0002359439422994 0.5618755064532134 0.764876139820259 0.1145101729902987 0.00037663596745094954 3.1523161450332144e-05 0.11093242260552319 0.03695799941356309 3.334698493711026e-11 10.47694342664607 -0.43836043748908604 IAEGVNSLLQMAGLLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAEGVNSLLQMAGLLAR 17 0 P35250;P35250-2;A0A087WVY3 P35250 RFC2 Replication factor C subunit 2 0 11348300.0 4576200.0 2199900.0 4572200.0 False True 3805313.0600337074 2188048.702054037 5528225.880535761 1.0 0.57499834245823 1.452765066453374 21.859583717291937 -6.775023354216452 1.5551507502652753 0.7578094291511784 1.458680880771408 0.7494855170526449 0.1793875540716974 0.2583508847068654 1.2337097584541084 0.09088608315833367 0.2153719738905716 1.678713742745165e-07 6.775023354216452 0.7008714516202296 IAEIIK(ub)NDLWVNPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAEIIKNDLWVNPLR 15 1 Q9H2G4 Q9H2G4 TSPYL2 Testis-specific Y-encoded-like protein 2 1 5853800.0 1376600.0 2694100.0 1783100.0 True False 1804735.9310133643 2292150.7815195485 1598601.9167029667 1.0 1.2700754399190686 0.8857816200319939 20.783356326720302 -6.71782254536847 1.7670234016554816 1.1646919080846732 0.886448294975106 0.5022471633021287 0.11368038517357577 0.35958224618734014 2.1929940680503788 0.05110459685296854 0.12862754898031947 1.9150382582156875e-07 6.71782254536847 -0.27824361310956713 IAEIIK(ub)NDLWVNPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAEIIKNDLWVNPLR 15 1 Q9H2G4 Q9H2G4 TSPYL2 Testis-specific Y-encoded-like protein 2 1 20556900.0 8001100.0 6572700.0 5983100.0 True False 7747109.460080712 9197213.386177689 4415946.620847426 1.0 1.1871799970774994 0.5700121630657093 22.885226693197474 -6.8253408657253845 1.348551219791988 1.1003823847551988 0.5549250644444055 0.8962405565137568 0.08322723835705112 0.18663123509065307 0.6653950775935812 0.048478070799356 0.11161068736618882 1.4950617628552892e-07 6.8253408657253845 -0.5454573203107933 IAEIIK(ub)NDLWVNPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAEIIKNDLWVNPLR 15 1 Q9H2G4 Q9H2G4 TSPYL2 Testis-specific Y-encoded-like protein 2 1 49680000.0 10494000.0 22637000.0 16549000.0 True False 15920165.21416423 18597250.48631175 13278082.896315642 1.0 1.1681568775282374 0.8340417776884679 23.92435197197869 -6.769857757027664 1.5748824711253853 1.0964664345872734 0.8321671155220031 0.7300729276067988 0.07086745452829776 0.26665155341291524 1.3051832374208674 0.035468735615513086 0.08444530771561161 1.6987999634406968e-07 6.769857757027664 -0.2642993190652704 IAEIIK(ub)NDLWVNPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAEIIKNDLWVNPLR 15 1 Q9H2G4 Q9H2G4 TSPYL2 Testis-specific Y-encoded-like protein 2 1 8448500.0 1376600.0 2358400.0 4713500.0 True False 1885566.2212162055 2254198.0898141228 3600268.3775796685 1.0 1.1955019476113369 1.909383153489813 20.846566388243193 -6.946971664793821 0.5911672197085542 0.9917768029309711 2.1491012174236173 0.998941607104757 0.012715278763376444 0.08472525842866435 0.041175932029633495 0.013166601386570359 0.05982632101056855 1.1298696297345138e-07 6.946971664793821 1.157324414492646 IAEIIK(ub)NDLWVNPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAEIIKNDLWVNPLR 15 1 Q9H2G4 Q9H2G4 TSPYL2 Testis-specific Y-encoded-like protein 2 1 19307600.0 8001100.0 5808500.0 5498000.0 True False 6653269.158829526 5777208.457603015 6647606.3801202085 1.0 0.868326279861398 0.999148872745994 22.66563196863175 -10.822316193558683 7.8397908310944775 1.0026807939852616 0.933737576304048 0.25487926658728666 0.05340809989918623 0.002597893005982284 5.8879517774850145e-05 0.05368303602828947 0.017237390121844193 1.5055105611776034e-11 10.822316193558683 -0.06894321768121359 IAEIIK(ub)NDLWVNPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAEIIKNDLWVNPLR 15 1 Q9H2G4 Q9H2G4 TSPYL2 Testis-specific Y-encoded-like protein 2 1 41187200.0 10494000.0 22081000.0 8612200.0 True False 13584689.867665416 20852172.939241022 7044867.968634303 1.0 1.5349760018352596 0.5185887964511178 23.69547829407114 -6.763693021027357 1.5984860268247483 1.309320824740384 0.5141750736579814 0.7058485665198839 0.2251489840223153 0.27677994636100933 1.3946105393929256 0.11108817205919871 0.266006973678382 1.7230860997841556e-07 6.763693021027357 -0.7951457510824026 IAELK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAELKLR 7 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 5690800.0 1735000.0 1619900.0 2335900.0 True False 2274601.8017638987 1378217.234320744 2094203.4755350018 1.0 0.6059158281031738 0.920690150650104 21.11718257445858 -9.8898258276141 6.3996858415231985 1.0000000185963127 0.7633029893766172 0.4298488056341131 0.12850607906178263 3.412025226878181e-08 5.7942979965143936e-09 0.12442548529355138 0.041475158674380015 1.2887663035892595e-10 9.8898258276141 -0.2366970292196955 IAELK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAELKLR 7 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 8940400.0 1340800.0 2204200.0 5395400.0 True False 1298237.0379168147 3084348.5547511503 3982182.881469512 1.0 2.375797689226597 3.067377347251953 20.30812239041598 -9.15876505471604 0.22624333181535683 1.28026031447767e-16 3.6300040530226463 0.9993364629861242 0.022134194811178606 0.5988897614668313 0.08073920953510051 0.7803992349669789 0.33173632100561296 6.938010380427934e-10 9.15876505471604 3.6300040530226463 IAELK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAELKLR 7 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 25229800.0 3408300.0 8390500.0 13431000.0 True False 5170640.280106342 6893149.719724274 10776356.962983584 1.0 1.3331327159317503 2.0841436222985426 22.301911509775252 -6.957637900077116 0.46754083525496654 0.979682247936165 2.4682544141887086 0.9996722940210293 0.008208223859134231 0.08055603583945026 0.024333181274315174 0.010336607287069007 0.06199661109666125 1.1024581184207861e-07 6.957637900077116 1.4885721662525437 up IAELK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAELKLR 7 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 6532100.0 1735000.0 1641400.0 3155700.0 True False 2376476.386612024 1568877.5206160557 2410388.653681587 1.0 0.6601696231674721 1.014269978553378 21.180392635981473 -10.982525120748257 11.812821587267026 1.1011984695438048 0.8372198008604332 0.21982662277587817 0.14456086473894245 0.07344076523853524 0.00010864192489233441 0.026680483300419566 0.04665681847060556 1.04105788832378e-11 10.982525120748257 -0.2639786686833716 IAELK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAELKLR 7 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 10832300.0 1340800.0 3547000.0 5944500.0 True False 1114934.6075112964 3527891.606975623 7187467.465737463 1.0 3.1642139217926095 6.446537238431394 20.088527665850258 -6.965073271579302 0.356792514323606 0.7065938974269164 9.01608050618226 0.9999146480325561 0.02068620401880332 0.07793610677356522 0.01477231482838163 0.044336265764965084 0.28089943643788146 1.0837440557515237e-07 6.965073271579302 8.309486608755343 IAELK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAELKLR 7 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 19288800.0 3408300.0 8944900.0 6935600.0 True False 4412111.53763713 8447108.451800954 5673391.965265569 1.0 1.914527404791025 1.285867756712222 22.0730378318677 -10.356430355840011 5.556399595635783 0.9998406457286185 1.6001975807516269 0.5486010256940184 0.2566492266118048 0.0005067722661855904 5.8696431509462075e-05 0.24856447686463842 0.08283318170704151 4.401185202894063e-11 10.356430355840011 0.6003569350230084 IAELLCK(ub)NDVTDGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAELLCKNDVTDGR 14 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;C9J6W1;Q7Z3J3-2;C9J1W9;C9JF75;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RGPD5;RGPD6;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 1 17278400.0 5978500.0 3491000.0 7808900.0 True False 7739286.10385341 3296722.781164371 6387760.326080269 1.0 0.42597246527983046 0.8253681593318778 22.883769063092938 -9.986396845979755 5.578758939349817 1.0000008290994287 0.6256703123055158 0.5394306140900407 0.1630526093166427 1.6812887170874154e-06 3.057284321893326e-07 0.1578753582643314 0.05262500336973451 1.0318181287163596e-10 9.986396845979755 -0.3743305167939128 IAETDFEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAETDFEKR 9 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EK03;K7EIH8;K7EPP7;K7ESP1;K7EJV7;K7EN19;K7EJL5 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 2189890.0 771240.0 634800.0 783850.0 True False 1011103.1086987836 540090.3144310191 702744.7212201325 1.0 0.5341594836218793 0.6950277525350644 19.94749869497601 -10.175250620997526 5.574905552892291 1.0000097278980191 0.6145936180784386 0.8844340969621554 0.06567419577380633 7.940737389623517e-06 1.1748668053401142e-06 0.06359036983680758 0.021196255542276065 6.679583434819968e-11 10.175250620997526 -0.3854161098195805 IAETDFEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAETDFEKR 9 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EK03;K7EIH8;K7EPP7;K7ESP1;K7EJV7;K7EN19;K7EJL5 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 12980400.0 2182600.0 4333000.0 6464800.0 True False 2825418.725478039 4091864.7409868785 5288272.734449623 1.0 1.4482330367845093 1.871677527568905 21.43003325929636 -6.971813802152998 0.2104021147597623 0.7794363568886674 2.552300504878288 0.9999932857707985 0.0009222068065059685 0.07571842992127195 0.006883007188474432 0.012639819311595867 0.043838391718012557 1.0670535078396412e-07 6.971813802152998 1.7728641479896203 IAEVDASVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAEVDASVVR 10 0 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 7518370.0 3436900.0 681070.0 3400400.0 False True 3327797.4907639446 953024.8027331305 2509733.2301866296 1.0 0.2863830522675073 0.7541724630636955 21.66613621194984 -9.78345565471287 6.392903953008892 1.0000000080119633 0.520277757666752 0.5837192419359483 0.1909742272554186 2.1826794616005447e-08 3.879045451539723e-09 0.1849100059391682 0.06163666680947443 1.6464340731482538e-10 9.78345565471287 -0.4797222503452113 IAEVGAGGSK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAEVGAGGSKSR 12 1 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 1 3760120.0 1253100.0 1515400.0 991620.0 True False 1213321.0264122619 2120507.1227066014 731884.9740376617 1.0 1.7476884324479647 0.6032080200586436 20.21052988560058 -6.730421637593361 1.721529354325307 1.4497489381321327 0.603819471009613 0.5612387779807071 0.3143015972935289 0.33547531773975686 1.94796205602825 0.14466345565203545 0.3588237057872156 1.860280194662328e-07 6.730421637593361 -0.8459294671225197 IAEVGAGGSK(ub)SR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAEVGAGGSKSR 12 1 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 1 2884110.0 1030300.0 668110.0 1185700.0 True False 1563040.4250193853 548880.5505327448 951345.875289228 1.0 0.3511620952004088 0.60865084489253 20.57592366066291 -10.325648830359441 5.768793117179732 1.000066971351796 0.4799064700465359 0.844716335248682 0.10511934187549413 9.055535872518263e-05 1.0585543615855247e-05 0.10179438982127575 0.033927121704004866 4.7244490485119215e-11 10.325648830359441 -0.5201605013052601 IAEVGAGGSK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAEVGAGGSKSR 12 1 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 1 3542940.0 1253100.0 1796200.0 493640.0 True False 1042008.171742546 1786523.5140822164 596857.8416665223 1.0 1.7145004833259805 0.5727957398533635 19.990935161034855 -6.7374972467817305 1.6957905575384808 1.4263519690750068 0.5724768497253572 0.593679695000363 0.30022587268452056 0.3223656625231135 1.8192228882569432 0.14011201675488205 0.34478056360619275 1.8302177089748503e-07 6.7374972467817305 -0.8538751193496497 IAEVGAGGSK(ub)SR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAEVGAGGSKSR 12 1 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 1 2400280.0 1030300.0 921250.0 448730.0 True False 1333743.6602492565 869981.6276561666 367065.74435861583 1.0 0.6522854830242119 0.27521461229665134 20.347049982755358 -7.37291759665396 0.3224971169420308 1.0668736688013296 2.9723303359055144e-17 0.9997379827902515 0.004790900051930493 0.11260497614519199 0.02724361632432104 0.015607110374606409 0.05559373219163803 4.23723355995716e-08 7.37291759665396 -1.0668736688013296 down IAEVGGVPYLLPLVNQKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAEVGGVPYLLPLVNQKK 18 1 A0A1W2PRB8;Q9H0W9;Q9H0W9-2;E9PQS1;A0A087WT99;E9PPB5;Q9H0W9-3;E9PIP1;E9PLB3;E9PLC5;E9PSC3;E9PR95 A0A1W2PRB8 C11orf54 Ester hydrolase C11orf54 1 12234500.0 4399600.0 4910700.0 2924200.0 True False 5767918.205787009 4178042.7017586725 2621631.8349070805 1.0 0.7243588679130022 0.4545195929229322 22.459619275348444 -6.971386799735321 0.2225961026920071 1.1204298314586356 0.050806081972902914 0.9999912696680164 0.0006579764960772656 0.07585531537422939 0.007399524673620744 0.007327972662733555 0.027201261140671035 1.068103160810352e-07 6.971386799735321 -1.0696237494857328 down IAEVGGVPYLLPLVNQKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAEVGGVPYLLPLVNQKK 18 1 A0A1W2PRB8;Q9H0W9;Q9H0W9-2;E9PQS1;A0A087WT99;E9PPB5;Q9H0W9-3;E9PIP1;E9PLB3;E9PLC5;E9PSC3;E9PR95 A0A1W2PRB8 C11orf54 Ester hydrolase C11orf54 1 20105600.0 6166500.0 4158900.0 9780200.0 True False 9355031.331536472 3416711.801365985 7847139.183186054 1.0 0.36522718954964994 0.8388148478704495 23.157311054620976 -9.8890876294244 6.450704291968758 1.0000000271451912 0.6020210187101073 0.484956144501852 0.19334135189435636 7.545675406073312e-08 1.2756908566699094e-08 0.18720197155780957 0.06240065300165692 1.2909587651522275e-10 9.8890876294244 -0.39797900843508394 IAEVGGVPYLLPLVNQKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAEVGGVPYLLPLVNQKK 18 1 A0A1W2PRB8;Q9H0W9;Q9H0W9-2;E9PQS1;A0A087WT99;E9PPB5;Q9H0W9-3;E9PIP1;E9PLB3;E9PLC5;E9PSC3;E9PR95 A0A1W2PRB8 C11orf54 Ester hydrolase C11orf54 1 12713500.0 4399600.0 5145900.0 3168000.0 True False 6026251.014719466 4918537.122784299 2419783.647008041 1.0 0.8161852386783239 0.4015404670495105 22.522829336871336 -6.957624815535449 0.4677070611104148 1.0111995090606976 0.18959325762361254 0.9996717115722441 0.0045351998752127766 0.08056073967844751 0.024350825685078657 0.0057087475500522105 0.03422885746946048 1.102491334077656e-07 6.957624815535449 -0.821606251437085 down IAFAITAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAFAITAIK 9 0 P62269;A0A0G2JQH2;Q5GGW2 P62269 RPS18 40S ribosomal protein S18 0 213604470.0 74197000.0 79737000.0 59670470.0 False True 97272985.52477016 67840550.41239168 53496342.16396542 1.0 0.6974243675816485 0.5499609359717124 26.535535862221103 -13.9999999999976 0.09447767427278214 2.5217699911103186 0.20714915001648915 0.9998210118316044 0.0025062146116583556 12.124749033740564 0.09037352377453434 3.6528376051467237 0.30686598119599773 1.0000000000055258e-14 13.9999999999976 -2.3146208410938294 IAFAITAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAFAITAIK 9 0 P62269;A0A0G2JQH2;Q5GGW2 P62269 RPS18 40S ribosomal protein S18 0 218298000.0 85030000.0 42186000.0 91082000.0 False True 82330769.19306879 59031089.79708374 67224891.79857029 1.0 0.7169991289484201 0.8165220907984639 26.294928369053498 -10.91348592825951 10.753509598729822 1.0273824306314367 0.7667606098734464 0.8798526956127647 0.040630079037180654 0.02043024860971359 0.00016436506000511102 0.03013249181949707 0.013113301622174318 1.2204333638287355e-11 10.91348592825951 -0.26062182075799034 IAFAITAIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAFAITAIK 9 0 P62269;A0A0G2JQH2;Q5GGW2 P62269 RPS18 40S ribosomal protein S18 0 373047000.0 103920000.0 135140000.0 133987000.0 False True 157654237.56965402 111023211.1463608 107504410.72141176 1.0 0.7042196445706641 0.6818999119761351 27.232188707671128 -13.999999999999998 0.3665726662732813 5.03230759354427 0.679460394096403 0.9997849750702283 0.0021259341718364317 22.424853515184694 0.1962215544827769 70.94947028805997 0.006305714947845028 1.0000000000000041e-14 13.999999999999998 -4.352847199447867 IAFAITAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAFAITAIK 9 0 P62269;A0A0G2JQH2;Q5GGW2 P62269 RPS18 40S ribosomal protein S18 0 231158880.0 74197000.0 58458000.0 98503880.0 False True 101629635.99853176 55875132.265245125 75239292.29508919 1.0 0.5497917188845619 0.7403282670044805 26.598745923743994 -10.222820897365544 5.49268472939798 1.0000191141576888 0.6450599929444958 0.8222829048199887 0.07778622004093186 1.8208205811033064e-05 2.5763180022675172e-06 0.0753202347847938 0.02510539456523326 5.986584303311682e-11 10.222820897365544 -0.35495912121319306 IAFAITAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAFAITAIK 9 0 P62269;A0A0G2JQH2;Q5GGW2 P62269 RPS18 40S ribosomal protein S18 0 155711000.0 85030000.0 33352000.0 37329000.0 False True 70706212.46769498 33172326.156146362 45134321.31020505 1.0 0.4691571645320769 0.6383360066249696 26.075333644487774 -10.403163583674429 5.234660748791215 1.0003352319397851 0.5537465855785101 0.9026957809591144 0.06906697306712727 0.0002704114149985512 3.083143654837755e-05 0.0669229407507752 0.022291269705154756 3.952177272127796e-11 10.403163583674429 -0.44658864636127504 IAFAITAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAFAITAIK 9 0 P62269;A0A0G2JQH2;Q5GGW2 P62269 RPS18 40S ribosomal protein S18 0 393450000.0 103920000.0 180710000.0 108820000.0 False True 134526488.56944844 170653329.64314318 89015876.58749048 1.0 1.2685481607218527 0.6616977632738597 27.003315029763577 -6.786413066901545 1.5106750007385834 1.150793811392636 0.655869523295735 0.7894856208297809 0.11392030283473126 0.24073797701284666 1.0853896742421296 0.05937019996192724 0.13936958396617638 1.6352604498558976e-07 6.786413066901545 -0.4949242880969009 IAFIFNNLSQSNMTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAFIFNNLSQSNMTQK 16 0 A5YKK6-2;A5YKK6;A5YKK6-3;A5YKK6-4;H3BVC9 A5YKK6-2 CNOT1 CCR4-NOT transcription complex subunit 1 0 7386300.0 1850200.0 2819400.0 2716700.0 False True 2425630.117362286 2398756.5099351257 2435601.9444265324 1.0 0.988920978827397 1.004111025416806 21.209928140998038 -6.7111468931159095 1.7908455141434827 0.9931967037830811 1.0040768827701438 0.47054945870998666 0.004667847579439363 0.3728383727056509 2.33153317536089 0.002073544676283814 0.0052609917312921445 1.944702206161544e-07 6.7111468931159095 0.010880178987062727 IAFIFNNLSQSNMTQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAFIFNNLSQSNMTQK 16 0 A5YKK6-2;A5YKK6;A5YKK6-3;A5YKK6-4;H3BVC9 A5YKK6-2 CNOT1 CCR4-NOT transcription complex subunit 1 0 5692340.0 1799700.0 755540.0 3137100.0 False True 1742569.5086059745 1057231.0620890504 2315399.399017313 1.0 0.6067081151527878 1.3287271397682108 20.73278477360789 -6.758789115334297 1.616898350696598 0.7712040297250566 1.331217058781081 0.6859963304070602 0.1653934875119599 0.2849873443139133 1.4681409173211093 0.08071607748767333 0.19421612474452285 1.742652865159068e-07 6.758789115334297 0.5600130290560243 IAFIFNNLSQSNMTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAFIFNNLSQSNMTQK 16 0 A5YKK6-2;A5YKK6;A5YKK6-3;A5YKK6-4;H3BVC9 A5YKK6-2 CNOT1 CCR4-NOT transcription complex subunit 1 0 9387200.0 1850200.0 2110500.0 5426500.0 False True 2534268.9397749673 2017251.131509799 4144872.4622756075 1.0 0.7959893679196189 1.635529835536577 21.27313820252093 -6.842490347088836 1.270744466639791 0.8914788465750609 1.6645377779535449 0.9286524081609103 0.09549547227147034 0.1659145286551227 0.5193465723810177 0.05890020805214996 0.13580162903854018 1.437174996586099e-07 6.842490347088836 0.7730589313784839 IAFPYLYNNLPHHVHLTWYHTPNVVFIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAFPYLYNNLPHHVHLTWYHTPNVVFIK 28 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 166165000.0 46781000.0 27493000.0 91891000.0 False True 70970197.14921072 22586659.346210558 73728703.57274403 1.0 0.31825555308411246 1.0388685185379112 26.08070997824265 -11.795142488462199 13.902580227047064 0.9306806634474836 0.7107058322492744 0.0 0.33931258242828255 518754691.0379795 0.0 0.0 0.10362128195045457 1.6027194652901922e-12 11.795142488462199 -0.21997483119820915 IAFPYLYNNLPHHVHLTWYHTPNVVFIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAFPYLYNNLPHHVHLTWYHTPNVVFIK 28 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 138634900.0 46781000.0 20929000.0 70924900.0 False True 60558926.69137184 19764282.75193042 58017295.95092911 1.0 0.32636448219526226 0.9580304526631439 25.851836300335098 -10.847399194047162 10.359790656844853 1.0093914144454954 0.6421974674292101 0.29962653823468743 0.2578765525877097 0.05466287073372226 0.0008051882938170591 0.24400232575626868 0.08322929946246502 1.4210220140906748e-11 10.847399194047162 -0.36719394701628527 IAGAGLLFVGGGIGGTILYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAGAGLLFVGGGIGGTILYAK 21 0 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;A0A087WYS0;D6RAW4 B9A067 IMMT MICOS complex subunit MIC60 0 24083100.0 6206100.0 5401000.0 12476000.0 False True 9415107.426684273 4437149.351794387 10010113.131574942 1.0 0.47127973699148984 1.0631969108715962 23.166546125455284 -6.671146570655231 1.9330874936836182 0.6628601442107392 1.060829180676997 0.28425101676615416 0.22452834327869273 0.45847765594090945 3.304013693700995 0.09346614859489273 0.24936544216223702 2.1323251502839154e-07 6.671146570655231 0.3979690364662577 IAGAGLLFVGGGIGGTILYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAGAGLLFVGGGIGGTILYAK 21 0 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;A0A087WYS0;D6RAW4 B9A067 IMMT MICOS complex subunit MIC60 0 17050700.0 6206100.0 6829900.0 4014700.0 False True 8033918.79052015 6449810.061035378 3284065.7943006633 1.0 0.8028224119773296 0.40877507975009525 22.937672447547733 -6.960060158108787 0.4345859729742429 1.0149117524132598 0.18145970511165863 0.9997724214117264 0.0037078594929394844 0.07967964780006291 0.021052037256481006 0.005162518952477658 0.03268479740740019 1.0963263234184303e-07 6.960060158108787 -0.8334520473016012 down IAGQVAAANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAGQVAAANK 10 0 P39019;A0A075B6E2 P39019 RPS19 40S ribosomal protein S19 0 25057700.0 3073900.0 12127000.0 9856800.0 False True 4029912.6676899423 10317698.870675774 8836912.889102016 1.0 2.560278527472449 2.192829874441815 21.942317143745946 -9.98181817276118 5.46658358433256 0.9999962604680065 2.376554200959476 0.9492707933836976 0.1500102844412459 6.836868737523186e-06 1.2732954824432306e-06 0.1452472290901808 0.04841561111553786 1.0427539105998969e-10 9.98181817276118 1.3765579404914692 IAGQVAAANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAGQVAAANK 10 0 P39019;A0A075B6E2 P39019 RPS19 40S ribosomal protein S19 0 12487900.0 4835400.0 1914500.0 5738000.0 False True 4681902.873764148 2678969.833985608 4235045.663689818 1.0 0.5721967982287028 0.9045564971929744 22.15866357532638 -9.816983015636218 6.198234851138094 1.0000000121635235 0.7383766477106751 0.45240905698745126 0.13568527892183213 2.273344926101911e-08 4.421794220729623e-09 0.1313767122701762 0.043792235465727865 1.5241123575307817e-10 9.816983015636218 -0.2616233644528484 IAGQVAAANK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAGQVAAANK 10 0 P39019;A0A075B6E2 P39019 RPS19 40S ribosomal protein S19 0 18535780.0 770340.0 17022000.0 743440.0 False True 1168662.0993976817 13984291.10650697 596498.7581386724 1.0 11.966068818107777 0.5104116565824312 20.156426426489524 -6.656125356634742 1.9870447698484883 8.081337343709679 0.5589005598461291 0.21909276173324566 4.6735069090200065 0.49370903624268003 3.7432278205643157 1.9031294501660636 5.177568127593409 2.2073674969692795e-07 6.656125356634742 -7.52243678386355 IAGQVAAANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAGQVAAANK 10 0 P39019;A0A075B6E2 P39019 RPS19 40S ribosomal protein S19 0 24495900.0 3073900.0 10340000.0 11082000.0 False True 4210403.899024037 9883144.610192511 8464659.840954265 1.0 2.3473150907169273 2.01041516300048 22.005527205268837 -10.295643567595945 5.035585229025442 0.9996653296268344 2.1788651268590855 0.9422814389961757 0.1375388195489649 0.0005169053656352158 7.230221926707725e-05 0.13320715068273972 0.04439046313065735 5.062399707681345e-11 10.295643567595945 1.179199797232251 IAGQVAAANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAGQVAAANK 10 0 P39019;A0A075B6E2 P39019 RPS19 40S ribosomal protein S19 0 6389390.0 4835400.0 1054700.0 499290.0 False True 4020849.3445406673 1049018.121758442 603689.2305438732 1.0 0.26089465977698284 0.15013972890168986 21.939068850760655 -13.999999999999998 0.2672670159880018 6.6218974991462 0.11239131450711969 0.9995774862253365 0.007754266279461797 14.750858907090253 0.1636331994099914 44.98461417622899 0.04663588389308533 1.0000000000000041e-14 13.999999999999998 -6.50950618463908 IAGQVAAANK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAGQVAAANK 10 0 P39019;A0A075B6E2 P39019 RPS19 40S ribosomal protein S19 0 2494920.0 770340.0 982440.0 742140.0 False True 997220.3156715623 927766.3503658336 607078.1349994496 1.0 0.9303524364533668 0.6087703243296065 19.927552748581974 -6.941596680949541 0.6445439334886738 1.0035337400132436 0.5178204650379665 0.998365571119556 0.006888954722586567 0.08704587682827603 0.05134995631167828 0.006789937589622906 0.027489113509937147 1.1439401919499734e-07 6.941596680949541 -0.48571327497527705 IAGYVTHLMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 IAGYVTHLMK 10 0 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 0 179320100.0 54054400.0 37367200.0 87898500.0 False True 70865841.86355418 31792159.41620481 78803606.40194918 1.0 0.448624592330643 1.1120111513481834 26.078587063906898 -6.6860624056368465 1.8802358226913507 0.6530585887055719 1.1096264379144722 0.35213144355417514 0.23338219728638712 0.42519177087338467 2.9111606861589236 0.09940922555060747 0.26017716205300956 2.0603338337924449e-07 6.6860624056368465 0.45656784920890037 IAGYVTHLMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 IAGYVTHLMK 10 0 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 0 102755400.0 38018400.0 14388100.0 50348900.0 False True 36811526.70221998 20133343.362950295 37161012.655376844 1.0 0.5469304092116376 1.0094939271599346 25.13365424876228 -10.951610229631257 11.684812700660233 1.060327080992803 0.778212168185787 0.2346131740123799 0.18884076543334266 0.10412827875081068 0.000431221028581002 0.06415321006726152 0.060948094967366466 1.1178660595177309e-11 10.951610229631257 -0.28211491280701595 IAGYVTHLMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 IAGYVTHLMK 10 0 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 0 96822400.0 28641800.0 47900000.0 20280600.0 False True 43451704.59605962 39351870.75559182 16272130.520697227 1.0 0.905646190901344 0.37448773694767434 25.372909438812645 -6.937199251690628 0.6851271561649395 1.006348858516413 0.24233139478711543 0.9977735100322765 0.0129919989008874 0.08906802731671153 0.060605141362917496 0.012392876787434613 0.046308041044031516 1.1555819465212697e-07 6.937199251690628 -0.7640174637292977 down IAGYVTHLMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 IAGYVTHLMK 10 0 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 0 146253300.0 54054400.0 27665600.0 64533300.0 False True 74039772.44523402 26443242.31409498 49291863.64503283 1.0 0.35714915701091066 0.6657484486664678 26.14179712542979 -10.526763786340455 6.377399715618763 1.0004686985256745 0.511448802838799 0.769676122153891 0.12598513325674027 0.0008403381829822154 6.235734450220388e-05 0.12209579944079614 0.04066152691442311 2.973282766621113e-11 10.526763786340455 -0.48901989568687554 IAGYVTHLMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IAGYVTHLMK 10 0 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 0 84747200.0 38018400.0 28651100.0 18077700.0 False True 31613984.10069168 28496750.837501913 21857663.488159135 1.0 0.901397013003446 0.6913922464989445 24.914059524196556 -6.958796472547301 0.45207557049136304 1.0066303778564418 0.5778047341008019 0.9997229245429351 0.0021422076125671317 0.08013386888650964 0.022741169778731658 0.0028157470821451817 0.01736565345789607 1.0995209974384987e-07 6.958796472547301 -0.4288256437556399 IAGYVTHLMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IAGYVTHLMK 10 0 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 0 90950900.0 28641800.0 37442800.0 24866300.0 False True 37077374.71428434 35359075.265133515 20340888.54978419 1.0 0.9536563885012918 0.548606494028492 25.144035760905094 -6.928488773436145 0.7591008469535282 1.00651754522952 0.4685658000873282 0.9962326394891265 0.012444575897287048 0.09343044012876088 0.08158236924009396 0.011237259464155916 0.03695937738404015 1.1789929999587218e-07 6.928488773436145 -0.5379517451421919 IAHIPLYFVNAQFPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAHIPLYFVNAQFPR 15 0 Q9NRG9-2;Q9NRG9;F8VZ44 Q9NRG9-2;F8VZ44 AAAS Aladin 0 17803400.0 5718300.0 8832200.0 3252900.0 False True 7496746.676095975 7514470.187645954 2916321.112020122 1.0 1.0023641603905988 0.389011559016535 22.837833221928154 -6.9060314784025705 0.9223370688078634 1.0214553494963383 0.3161229478094295 0.9893357916287295 0.029801140683039528 0.10710116341299943 0.1534354587961709 0.023929620283361132 0.06437404279544799 1.241562313783206e-07 6.9060314784025705 -0.7053324016869088 down IAHIPLYFVNAQFPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAHIPLYFVNAQFPR 15 0 Q9NRG9-2;Q9NRG9;F8VZ44 Q9NRG9-2;F8VZ44 AAAS Aladin 0 27967300.0 10445000.0 6192300.0 11330000.0 False True 10113429.192303944 8664917.68241791 8362333.107285747 1.0 0.8567734561301608 0.8268543684123744 23.269768923558463 -13.99999999999994 0.22010256031593983 1.864679303652507 0.8108663006425173 0.9994979896665667 0.0016930318034161895 13.0024384535076 0.1486235788039089 4.886946026860039 0.016546813009946218 1.000000000000139e-14 13.99999999999994 -1.0538130030099895 IAHIPLYFVNAQFPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAHIPLYFVNAQFPR 15 0 Q9NRG9-2;Q9NRG9;F8VZ44 Q9NRG9-2;F8VZ44 AAAS Aladin 0 37658300.0 5718300.0 11611000.0 20329000.0 False True 7832510.041247005 11097987.627557583 15527708.888897244 1.0 1.4169132971568696 1.982469068935288 22.901043283451045 -6.966873992573299 0.3242826631633043 0.926338437385119 2.4914013686812324 0.9999467266892534 0.0029386497047911844 0.07733065310316921 0.012647613917909679 0.008428974021122958 0.04956310743792649 1.0792598162957605e-07 6.966873992573299 1.5650629312961133 IAHIPLYFVNAQFPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAHIPLYFVNAQFPR 15 0 Q9NRG9-2;Q9NRG9;F8VZ44 Q9NRG9-2;F8VZ44 AAAS Aladin 0 29458900.0 10445000.0 8025900.0 10988000.0 False True 8685480.291956661 7982662.883683585 13285539.997228242 1.0 0.9190813421194528 1.5296264052929285 23.05017419899274 -6.873511185510081 1.1153090304436932 0.953100026157495 1.5678596408428984 0.9680657638471429 0.04838590133420131 0.13353511794009917 0.3083191388796349 0.03359102096130893 0.08005283407846528 1.3381007511375225e-07 6.873511185510081 0.6147596146854034 IAIEDPFSVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAIEDPFSVKR 11 1 E9PKX1;E9PKY2;A0A0C4DFM7;Q5TAX3-2;Q5TAX3 E9PKX1 ZCCHC11 Terminal uridylyltransferase 4 1 5674400.0 1321800.0 1912800.0 2439800.0 True False 1279840.1825167383 2676591.0151202227 1800743.1875689141 1.0 2.091347850836225 1.4070062904478022 20.287532237138667 -10.098498405302163 4.824037761975186 0.9999664505771321 1.749177070324813 0.6150803979874266 0.27938127214497593 194444597.4389227 7.031899105041149 72465.1907816835 0.09563964055795877 7.970794174027303e-11 10.098498405302163 0.749210619747681 IAIEDPFSVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAIEDPFSVKR 11 1 E9PKX1;E9PKY2;A0A0C4DFM7;Q5TAX3-2;Q5TAX3 E9PKX1 ZCCHC11 Terminal uridylyltransferase 4 1 4887400.0 1464500.0 1752000.0 1670900.0 True False 2005965.2266243866 1674590.8469107617 1276267.8332656976 1.0 0.8348055213941781 0.6362362698646503 20.935865166395217 -6.968675912973241 0.28806414943879205 1.0397084954027918 0.4252148630731425 0.9999701309328828 0.0008127408481688523 0.07673474032607316 0.0105604708707037 0.0035056459573017413 0.018047863382560463 1.0747911631169958e-07 6.968675912973241 -0.6144936323296493 IAIEDPFSVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAIEDPFSVKR 11 1 E9PKX1;E9PKY2;A0A0C4DFM7;Q5TAX3-2;Q5TAX3 E9PKX1 ZCCHC11 Terminal uridylyltransferase 4 1 5875100.0 1321800.0 2802100.0 1751200.0 True False 1099135.265668578 2787004.5311266994 2117367.823366041 1.0 2.5356338006600403 1.926394220531261 20.067937512572943 -10.174066943278373 6.342133465706229 0.9999928866143298 2.231014010595653 0.8448079456398174 0.248721017070504 2.5017288787929203e-05 3.2574975110209405e-06 0.24082447537340784 0.08027436308048487 6.697813596223764e-11 10.174066943278373 1.2310211239813231 IAIEIYLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAIEIYLK 8 0 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 0 150306000.0 40274000.0 59393000.0 50639000.0 False True 61098602.42378982 48793855.11037297 40630179.45413783 1.0 0.7986083670446481 0.6649935979274995 25.864636044266543 -8.415252110829451 0.07125718701336393 1.6542961556101923 1.1109963471771805e-09 0.9999950793822653 0.00030538829167857005 0.11588813423679911 0.0162182105271311 0.18770275097733027 0.17935854953398436 3.843685887519423e-09 8.415252110829451 -1.6542961544991959 IAIEIYLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAIEIYLK 8 0 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 0 3162360.0 1465100.0 815930.0 881330.0 False True 1218295.5649349636 811534.4231405747 1065612.028190495 1.0 0.6661227755383784 0.8746744705151912 20.216432750464218 -10.419420275304146 5.805693191979307 1.0000977927667236 0.7703986230267845 0.6177472832867011 0.08514087294762569 0.00010781642634812274 1.0781920253642948e-05 0.08247226636854525 0.02747909858397621 3.806972368813944e-11 10.419420275304146 -0.2296991697399391 IAIEIYLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAIEIYLK 8 0 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 0 107453000.0 40274000.0 32554000.0 34625000.0 False True 52135486.919225946 30742341.282734115 28323605.282501917 1.0 0.5896624947679792 0.543269219416402 25.635762366358993 -13.999999999999998 0.3077065420034672 4.913700172767547 0.5327405228260449 0.9996669432315776 0.0037456975141976646 17.107966190074354 0.17641497462325081 42.81461004567242 0.016229459170994488 1.0000000000000041e-14 13.999999999999998 -4.380959649941502 IAIIGAGIGGTSAAYYLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAIIGAGIGGTSAAYYLR 18 0 F8W8W4;Q9UHG3 F8W8W4 PCYOX1 Prenylcysteine oxidase 1 0 12620900.0 4427200.0 3332800.0 4860900.0 False True 4286660.959326762 4663604.4203224 3587684.466125798 1.0 1.0879340504351056 0.8369415029942697 22.031422885326585 -6.812029155072927 1.40583815250208 1.0478093762421883 0.8323371239953599 0.865103451228663 0.0381922411987026 0.20403997239742544 0.7943756907118544 0.021358473806862094 0.04936613180184452 1.541596958932699e-07 6.812029155072927 -0.21547225224682842 IAIIGAGIGGTSAAYYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAIIGAGIGGTSAAYYLR 18 0 F8W8W4;Q9UHG3 F8W8W4 PCYOX1 Prenylcysteine oxidase 1 0 44407500.0 9989500.0 10983000.0 23435000.0 False True 15154801.830273857 9022997.83942933 18803061.978074633 1.0 0.5953887052092373 1.240732949771264 23.85327165124962 -6.737217524696261 1.6969718815480692 0.7584819293804224 1.2408790618817225 0.5923305034115023 0.1700153223919973 0.32288308891363277 1.8245990684093911 0.07929522916330295 0.19517422703626508 1.8313969024513565e-07 6.737217524696261 0.4823971325013001 IAIIGAGIGGTSAAYYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAIIGAGIGGTSAAYYLR 18 0 F8W8W4;Q9UHG3 F8W8W4 PCYOX1 Prenylcysteine oxidase 1 0 5756200.0 1074900.0 1470200.0 3211100.0 False True 1472319.5780802672 1405241.7026987462 2452704.314680405 1.0 0.9544406823218484 1.6658776743826533 20.48965942256038 -6.8916206136983975 1.012728582215078 0.9632455758295576 1.7290508240438198 0.9819160633519364 0.043727538452738135 0.11783881775841572 0.21423728316854163 0.03282694391772172 0.08233174824886673 1.283451276642448e-07 6.8916206136983975 0.7658052482142622 IAIIGAGIGGTSAAYYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAIIGAGIGGTSAAYYLR 18 0 F8W8W4;Q9UHG3 F8W8W4 PCYOX1 Prenylcysteine oxidase 1 0 11159500.0 4427200.0 2422600.0 4309700.0 False True 3681412.958214508 2409548.9729515505 5210838.344198623 1.0 0.6545174367290179 1.4154452117552954 21.81182816076086 -6.783248055109949 1.5230219399754956 0.8052044769869444 1.4221191900212886 0.7787743786023581 0.1463175970403135 0.24556173885346932 1.1252155606456082 0.07564881200185221 0.1780355782332802 1.647221282702493e-07 6.783248055109949 0.6169147130343442 IAIIGAGIGGTSAAYYLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAIIGAGIGGTSAAYYLR 18 0 F8W8W4;Q9UHG3 F8W8W4 PCYOX1 Prenylcysteine oxidase 1 0 33995600.0 9989500.0 15064000.0 8942100.0 False True 12931604.672483696 14225675.157679746 7314729.553694163 1.0 1.1000703716182738 0.5656474767790182 23.62439797334207 -6.858294614827903 1.1942644023819347 1.0540709897895737 0.5405920991997184 0.9515337240995727 0.05106797523037026 0.14857679234738064 0.4036347304822672 0.03337260562133521 0.07776111901522413 1.3858154064165667e-07 6.858294614827903 -0.5134788905898553 IAILGFAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAILGFAFK 9 0 O60701-3;O60701-2;O60701 O60701-3 UGDH UDP-glucose 6-dehydrogenase 0 6177000.0 1317300.0 2876600.0 1983100.0 False True 1726993.056751345 2447422.4928989788 1777907.8352384358 1.0 1.4171582701686345 1.029481750542105 20.719830851953294 -10.642369824421454 7.596904573961578 0.9995714067542503 1.2233200103553696 0.30673057360989375 0.15826827639051091 0.0011510284257857635 5.4185576610258574e-05 0.15352808414703736 0.05108086655778342 2.278401068242862e-11 10.642369824421454 0.22374860360111937 IAILGFAFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAILGFAFK 9 0 O60701-3;O60701-2;O60701 O60701-3 UGDH UDP-glucose 6-dehydrogenase 0 10380200.0 3529300.0 0.0 6850900.0 False True 5354206.12639126 0.0 5496816.6121438565 1.0 0.0 1.026635225164317 22.352241250289822 -12.103879529416105 18.350518610648507 0.8900871989365173 0.5619858513239523 0.0 0.4911155777543453 0.0 0.0 0.0 0.14149675581097745 7.872641415776797e-13 12.103879529416105 -0.32810134761256504 IAILGFAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAILGFAFK 9 0 O60701-3;O60701-2;O60701 O60701-3 UGDH UDP-glucose 6-dehydrogenase 0 11606300.0 1317300.0 3654900.0 6634100.0 False True 1804341.4086939592 3493414.4328619572 5067262.21357829 1.0 1.93611608979844 2.808372178991413 20.783040913476185 -6.971975635321307 0.20559242092894062 0.5168429614858528 4.251876081814776 0.9999939677841908 0.0018135881597757112 0.07566670484182893 0.006684664354742972 0.027057856986247273 0.09133174128518691 1.0666559608134232e-07 6.971975635321307 3.735033120328923 IAILGFAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAILGFAFK 9 0 O60701-3;O60701-2;O60701 O60701-3 UGDH UDP-glucose 6-dehydrogenase 0 5287900.0 2490400.0 1170600.0 1626900.0 False True 2070877.9434264102 1164293.7454540932 1967077.268064307 1.0 0.5622222927961119 0.9498760051544333 20.981811093620085 -10.264658880535817 8.06389026604348 1.000000286808648 0.7560491489752726 0.3455609825958914 0.15825896536225478 8.159431228344038e-07 7.44708351859824e-08 0.1532337624067453 0.05107786143633579 5.436771986679113e-11 10.264658880535817 -0.2439511378333753 IAILTCPFEPPKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAILTCPFEPPKPK 14 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 24533200.0 5392400.0 8647800.0 10493000.0 False True 7069488.62007588 7357581.948860391 9407285.015963342 1.0 1.0407516504045833 1.3306881899842948 22.753174429059914 -6.9323445551805865 0.7272816780869386 0.9959519385419154 1.3939293685733267 0.9969794796624059 0.008091411757392338 0.09143825669665892 0.07184712105648002 0.007477330891461294 0.02590425657965821 1.1685719160314265e-07 6.9323445551805865 0.3979774300314113 IAILTCPFEPPKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAILTCPFEPPKPK 14 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 14203500.0 6803500.0 3438100.0 3961900.0 False True 6587526.616547623 4810951.25945465 2924159.535547698 1.0 0.7303122309016131 0.44389339212722384 22.65130545521766 -6.970362052979273 0.24938853818738244 1.0915823771379176 0.07424095525698718 0.9999850694216761 0.0008773580216281039 0.07618542602722556 0.008608840655939287 0.006414764945010129 0.02747803601210288 1.0706263970601439e-07 6.970362052979273 -1.0173414218809305 down IAILTCPFEPPKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAILTCPFEPPKPK 14 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 32225400.0 5392400.0 12020000.0 14813000.0 False True 7386116.004130653 11488916.655175444 11314474.483311266 1.0 1.5554747107614229 1.5318571326233836 22.816384490582806 -10.030348540108601 4.811774982344388 0.9999884038248102 1.5436659217028639 0.9985866371492375 0.009641835937827897 6665266.945446512 0.00048524887386901364 866.8174256219525 0.0033006568935750854 9.325056243123522e-11 10.030348540108601 0.5436775178780536 IAILTCPFEPPKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAILTCPFEPPKPK 14 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 13668300.0 6803500.0 2281500.0 4583300.0 False True 5657411.696153871 2269209.106657708 5541646.839215157 1.0 0.4011037606120136 0.9795374876080849 22.431710730651936 -10.89721181886487 10.67716355510932 1.0247415019888118 0.6903206241100613 0.27649976370969664 0.23614458019278697 0.10965918787517862 0.001055678051308474 0.180279623493759 0.07621533553198379 1.2670337435464712e-11 10.89721181886487 -0.3344208778787504 IAILTCPFEPPKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAILTCPFEPPKPK 14 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 16158500.0 6331900.0 5333400.0 4493200.0 False True 8196769.37040888 5036591.6015646 3675483.7041252735 1.0 0.6144605726918677 0.44840638281151607 22.966623975193546 -13.999999999999998 0.11485973550171891 2.846855371172948 0.16404102517773925 0.9997184903519559 0.003876663606018189 11.986316397612933 0.10360308424554399 5.090937967359687 0.25236240314160774 1.0000000000000041e-14 13.999999999999998 -2.682814345995209 IAIPGLAGAGNSVLLVSNLNPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAIPGLAGAGNSVLLVSNLNPER 23 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 11540500.0 5177700.0 4794300.0 1568500.0 False True 6788014.840918126 4079009.1280350247 1406206.6661144078 1.0 0.6009134074732386 0.20716022269689216 22.694558288432148 -7.640099382414497 0.3533811128900711 1.0635384696109664 2.7109830619886452e-12 0.9991137933809487 0.00963563849380518 0.12303088474019977 0.04898648706811201 0.027193488231863155 0.07365753969599609 2.290343478687111e-08 7.640099382414497 -1.0635384696082555 down IAIPGLAGAGNSVLLVSNLNPER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAIPGLAGAGNSVLLVSNLNPER 23 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 93968000.0 52412000.0 19134000.0 22422000.0 False True 50748209.74887836 26774305.982491843 16549005.554418465 1.0 0.527591142918763 0.3261002828732147 25.596853593268538 -13.853462256891586 0.11891791470581052 3.1834703223672953 3.5717017779134035e-16 0.9997065872968708 0.004837853909322476 11.351095823081481 0.10422062843648564 5.915718963319382 0.28607106877538074 1.4013213638899426e-14 13.853462256891586 -3.183470322367295 IAIPGLAGAGNSVLLVSNLNPER ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAIPGLAGAGNSVLLVSNLNPER 23 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 126120000.0 20062000.0 76376000.0 29682000.0 False True 30435520.728660453 62746106.07158825 23815339.68991725 1.0 2.0616077717540624 0.7824850411542614 24.859252713655632 -6.686331517471872 1.879133655411391 1.66781381796251 0.787049520618884 0.3534873050921896 0.4493217368482149 0.42458307945974394 2.903765620867108 0.19147946366165744 0.5010023317979417 2.059057537429242e-07 6.686331517471872 -0.8807642973436259 IAIPGLAGAGNSVLLVSNLNPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAIPGLAGAGNSVLLVSNLNPER 23 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 14735800.0 5177700.0 1873400.0 7684700.0 False True 7092035.612081318 1790626.993494647 5869732.131364482 1.0 0.2524842078407369 0.8276512488692759 22.75776834995504 -10.223075878778639 7.487834978161336 1.0000007001873685 0.5400677283565571 0.4602141775077774 0.2348109612310596 2.744600131748918e-06 2.850425678016724e-07 0.22735508111619032 0.0757849118629041 5.983070513085411e-11 10.223075878778639 -0.4599329718308114 IAIPGLAGAGNSVLLVSNLNPER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAIPGLAGAGNSVLLVSNLNPER 23 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 77787000.0 52412000.0 10286000.0 15089000.0 False True 43582900.245287955 10230587.276388846 18244040.13634663 1.0 0.23473856073850766 0.4186054630065405 25.377258868702814 -10.793275476821961 10.509704162888767 1.0045249427127305 0.32667201190972817 0.9470359120247094 0.0750633485238106 0.007917081140798457 0.00015572766283786612 0.072301115546683 0.024226591561940118 1.6096243123912742e-11 10.793275476821961 -0.6778529308030024 IAIPGLAGAGNSVLLVSNLNPER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAIPGLAGAGNSVLLVSNLNPER 23 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 64134000.0 20062000.0 26950000.0 17122000.0 False True 25970654.481141943 25450208.80904602 14005971.68655589 1.0 0.9799602404138935 0.5392999123963563 24.63037903574808 -6.9164090725363145 0.8509277248402459 1.0110371852215791 0.4737931659417959 0.993124010313654 0.017629970330044972 0.10033115912403393 0.11690119029212209 0.014907936742420663 0.043232489557206155 1.2122464680955003e-07 6.9164090725363145 -0.5372440192797833 IAIYELLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAIYELLFK 9 0 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;P46783 A0A1W2PQS6;P46783 RPS10 40S ribosomal protein S10 0 264640000.0 83513000.0 92823000.0 88304000.0 False True 109486351.74104238 78974170.22122003 79167149.15177989 1.0 0.7213152047299018 0.7230777890839435 26.70617579785018 -10.134622565955157 5.463361394280891 1.0000051983775928 0.7221964969068538 0.9999698074013276 0.0007195720495827355 4.5563222565396445e-08 7.21757529033192e-09 0.0006967356778979845 0.00023224088033341303 7.334616887186333e-11 10.134622565955157 -0.277808701470739 IAIYELLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAIYELLFK 9 0 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;P46783 A0A1W2PQS6;P46783 RPS10 40S ribosomal protein S10 0 871630000.0 350630000.0 278750000.0 242250000.0 False True 339499442.5751585 390056328.66204685 178797457.65577894 1.0 1.1489159619921794 0.5266502245175166 28.33883396480686 -6.843554211866471 1.2658814443339517 1.0792199390750457 0.5047139347033036 0.9303724054077791 0.0700044782727956 0.16469590165373205 0.5111344944105707 0.04333650838081155 0.099949363075954 1.4336587449411334e-07 6.843554211866471 -0.574506004371742 IAIYELLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAIYELLFK 9 0 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;P46783 A0A1W2PQS6;P46783 RPS10 40S ribosomal protein S10 0 120041000.0 27218000.0 43862000.0 48961000.0 False True 41291695.9023368 36034483.404629804 39283836.88963138 1.0 0.8726811194642776 0.9513737818506073 25.299348337258117 -10.261110001079949 4.838635266688686 1.0000233952300404 0.9120274506581009 0.6249545858689747 0.032126144891680836 8.110101074815491e-06 1.2384695757581152e-06 0.03111427627773124 0.010368668678551926 5.481381111628366e-11 10.261110001079949 -0.08799594457193949 IAIYELLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAIYELLFK 9 0 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;P46783 A0A1W2PQS6;P46783 RPS10 40S ribosomal protein S10 0 924103000.0 83513000.0 188540000.0 652050000.0 False True 114390012.95396543 180209679.38159534 498049219.3912857 1.0 1.5753969662903882 4.3539571902288206 26.76938585937307 -6.940584640442234 0.6541010690755771 0.9690981986453485 5.116313694769647 0.9982394889012998 0.061444425861746095 0.08750090939462447 0.053402461297604266 0.0600799023872956 0.23853576594429474 1.1466090349230626e-07 6.940584640442234 4.147215496124298 IAIYELLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAIYELLFK 9 0 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;P46783 A0A1W2PQS6;P46783 RPS10 40S ribosomal protein S10 0 580490000.0 350630000.0 105360000.0 124500000.0 False True 291564380.54272497 104792404.76767735 150532374.37703997 1.0 0.35941428981350276 0.5162920590534255 28.119239240241136 -10.356656334525917 8.808759732665385 1.0000012100128712 0.43785317443464644 0.944813765235564 0.06404508110398284 1.521955495310462e-06 1.1119480829624296e-07 0.06201151707918228 0.02067046104351907 4.3988957072201236e-11 10.356656334525917 -0.5621480355782248 IAIYELLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAIYELLFK 9 0 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;P46783 A0A1W2PQS6;P46783 RPS10 40S ribosomal protein S10 0 109111000.0 27218000.0 48381000.0 33512000.0 False True 35234237.546990424 45688554.81968298 27413159.86215749 1.0 1.2967090534810088 0.7780261975471361 25.070474659350566 -6.751541483947778 1.6439994531045932 1.174142557136794 0.7768638462928048 0.6556370102894256 0.12469012335914596 0.297362783753253 1.5817011628788629 0.05990132751321348 0.14519766881390414 1.7719787770715949e-07 6.751541483947778 -0.39727871084398925 IAK(ub)DETFSSYYGEDDYPIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAKDETFSSYYGEDDYPIVR 20 1 P60852 P60852 ZP1 Zona pellucida sperm-binding protein 1;Processed zona pellucida sperm-binding protein 1 1 9576300.0 1741200.0 1982500.0 5852600.0 True False 1685926.5590846934 2774122.58860092 4319628.485763512 1.0 1.6454587381949894 2.5621688338006146 20.68511026150453 -6.966149268415408 0.33774699177853834 0.8979385034145444 3.3400501989152342 0.999934913293804 0.005170941918212823 0.07757309153712855 0.013496602857437288 0.013031751032160636 0.07947763883238748 1.0810623228264322e-07 6.966149268415408 2.4421116955006896 IAK(ub)ESQFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAKESQFLK 9 1 P35221;P35221-2;G3XAM7;E5RIB1;E5RHV7;E5RGY6;E5RG03;E5RFM3;E5RJL0;E5RIE0 P35221 CTNNA1 Catenin alpha-1 1 14011320.0 963110.0 645010.0 12403200.0 True False 1262646.536770508 548777.0222292884 11119835.843895588 1.0 0.4346244227881102 8.806768577005705 20.268019399251298 -6.890737752855732 1.018026091405783 0.5580775710526831 9.53729724153502 0.9813656707129844 0.5215116671672078 0.11854589576385512 0.21837634638482362 0.38995218629684963 0.9747582960196457 1.286063009995786e-07 6.890737752855732 8.979219670482337 up IAK(ub)ESQFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAKESQFLK 9 1 P35221;P35221-2;G3XAM7;E5RIB1;E5RHV7;E5RGY6;E5RG03;E5RFM3;E5RJL0;E5RIE0 P35221 CTNNA1 Catenin alpha-1 1 28591800.0 1041100.0 18185700.0 9365000.0 True False 1579424.8146051448 14940319.749477373 7514003.645174686 1.0 9.459342167681749 4.757430411179897 20.590967831399144 -9.381123010620797 11.007513853694938 0.9999798880462125 7.108386289430823 0.6923372472729081 1.9195474365389422 0.0 0.0 1.8585938134767457 0.6195312711589152 4.1579282364738686e-10 9.381123010620797 6.10840640138461 IAK(ub)ESQFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAKESQFLK 9 1 P35221;P35221-2;G3XAM7;E5RIB1;E5RHV7;E5RGY6;E5RG03;E5RFM3;E5RJL0;E5RIE0 P35221 CTNNA1 Catenin alpha-1 1 10917630.0 963110.0 568920.0 9385600.0 True False 1319197.7940691123 543783.2332331463 7168914.582499569 1.0 0.4122075064693882 5.4342984916513535 20.33122946077419 -6.877723933183038 1.092371126660267 0.645553555878592 5.775094112329175 0.9718046106188503 0.37642686612225124 0.1296673998778238 0.28460751715554866 0.2659631111061463 0.6396310617780078 1.3251836434741672e-07 6.877723933183038 5.129540556450583 up IAK(ub)ESQFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAKESQFLK 9 1 P35221;P35221-2;G3XAM7;E5RIB1;E5RHV7;E5RGY6;E5RG03;E5RFM3;E5RJL0;E5RIE0 P35221 CTNNA1 Catenin alpha-1 1 29046200.0 1041100.0 25456000.0 2549100.0 True False 1347724.4731490826 24039351.222377576 2085189.9559747495 1.0 17.83699242784203 1.5471930632101016 20.362094153491594 -9.424291898540162 8.632639706783706 1.002362103468948 9.692092745525967 0.2751658571558281 6.650282882444072 0.0 0.0 6.439109223979492 2.146369549878308 3.76450693432564e-10 9.424291898540162 8.689730642057018 IAK(ub)QIVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAKQIVQK 8 1 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 1 6002500.0 1425700.0 2792400.0 1784400.0 True False 1869106.5064984388 2375784.8046899494 1599767.4051734456 1.0 1.2710804849428916 0.855899543237068 20.83391734922542 -6.730534808126617 1.721426940414333 1.1630383294086524 0.8561288320620117 0.5616945995120768 0.11395080962982211 0.33522861929494646 1.9464087238260264 0.052453864209809284 0.1300746619750578 1.859795497106925e-07 6.730534808126617 -0.30690949734664064 IAK(ub)QIVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAKQIVQK 8 1 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 1 8927800.0 2753600.0 3166500.0 3007700.0 True False 2666188.4752444346 4430899.963079351 2219893.1409341004 1.0 1.6618854984260363 0.8326092328227404 21.346347338756832 -6.694118030592513 1.8518425559059257 1.4133460541535785 0.8353279239888486 0.38976738613552264 0.27970087761090195 0.40786128357564577 2.71490772109545 0.12068980308671247 0.3126561801943531 2.022469446369462e-07 6.694118030592513 -0.5780181301647299 IAK(ub)QIVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAKQIVQK 8 1 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 1 8234800.0 2232200.0 1671300.0 4331300.0 True False 3386410.595679193 1373043.4570734983 3475216.6565237716 1.0 0.4054568748471905 1.0262242449152175 21.691325477122767 -10.929612411258095 13.12279579532302 1.0338750648130808 0.715840559884418 0.21837526552012543 0.2534272176060202 0.13736314963844928 0.0007367822557872418 0.1341983611860648 0.08179328277198324 1.1759465674106612e-11 10.929612411258095 -0.3180345049286628 IAK(ub)QIVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAKQIVQK 8 1 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 1 6220000.0 1425700.0 2491200.0 2303100.0 True False 1952819.8180938119 2381130.5467032488 1759155.2138334026 1.0 1.2193293639489586 0.9008282267180956 20.89712741074831 -6.721398785823353 1.7541120935805528 1.133237696106847 0.9012800663520983 0.5191514212959067 0.0922793307504508 0.3526251944720503 2.1211442384412638 0.04175727918967118 0.10466104804796052 1.8993334382631122e-07 6.721398785823353 -0.23195762975474876 IAK(ub)QIVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAKQIVQK 8 1 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 1 7615150.0 2753600.0 3929400.0 932150.0 True False 2289740.4051634124 3908231.542275165 1127058.255225363 1.0 1.706844816758276 0.49222097521789937 21.12675261419111 -6.748937663810175 1.653686680171175 1.4161599362701933 0.48998777998356985 0.6444258664957168 0.29700708709809903 0.3019004690657847 1.6240246618679617 0.14189616005976305 0.34488275558401515 1.7826346184432458e-07 6.748937663810175 -0.9261721562866234 IAK(ub)QIVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAKQIVQK 8 1 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 1 6496500.0 2232200.0 1501000.0 2763300.0 True False 2889626.9032402122 1417468.0305149565 2260407.7538523483 1.0 0.4905366948672555 0.7822489994530767 21.462451799215216 -10.20059101117949 5.630994026876344 1.000011459487018 0.6363928471601515 0.6744307959232378 0.11909104965449549 1.7133507931648015e-05 2.4324279309274847e-06 0.11531304456710971 0.03843647099950971 6.300992879266801e-11 10.20059101117949 -0.36361861232686643 IAK(ub)QSGELESHADR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAKQSGELESHADR 14 1 Q76N32-2;Q76N32 Q76N32-2 CEP68 Centrosomal protein of 68 kDa 1 1682480.0 450240.0 466320.0 765920.0 True False 590269.0001303623 396746.8737011231 686669.9456234286 1.0 0.6721458752085924 1.1633169715363263 19.171013050454768 -6.726810293444709 1.734933115185784 0.8019988899217693 1.1628541958549488 0.5443671717065859 0.13786024791865523 0.34225919024832957 2.0167522819808967 0.06300969673785083 0.15691773725869057 1.8758137136129967e-07 6.726810293444709 0.3608553059331795 IAK(ub)QSGELESHADR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAKQSGELESHADR 14 1 Q76N32-2;Q76N32 Q76N32-2 CEP68 Centrosomal protein of 68 kDa 1 6481000.0 717000.0 2421100.0 3342900.0 True False 1087741.4197213415 1989035.7888593583 2682174.349754878 1.0 1.8285924878809077 2.4658198181347175 20.052904206037788 -6.982273903475806 0.12924324930553002 3.3064348752586023e-11 4.305667309607149 0.9999992680840148 0.0005133792287909411 0.07410847193068602 0.003855454381632696 0.040295254650606085 0.08668593803038056 1.0416602615752409e-07 6.982273903475806 4.305667309574085 IALALTAISLGTARPPPSMSAAGLAAR ddPTM_RPMI8226_Bortezomib_8h_R1 2 IALALTAISLGTARPPPSMSAAGLAAR 27 1 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 287392700.0 64507700.0 115565000.0 107320000.0 False True 97862897.04457249 94941522.8365338 86108154.9599731 1.0 0.9701482962771056 0.8798856109967234 26.544258655852033 -6.951274443119477 0.5446826662084683 1.0012894907432768 0.8445425706521948 0.9992974629422636 0.0013534070083968542 0.08297818699497778 0.03387681294931508 0.0014792021112433106 0.007480836704037266 1.1187307020802273e-07 6.951274443119477 -0.15674692009108193 IALALTAISLGTARPPPSMSAAGLAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 IALALTAISLGTARPPPSMSAAGLAAR 27 1 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 28672750.0 6610160.0 6310500.0 15752090.0 False True 9054114.784857258 6031681.243967108 12031770.766476916 1.0 0.6661812211675203 1.328873230831986 23.11014216600211 -6.769738747430173 1.57528890177696 0.8084665395021111 1.3325783813083176 0.7296153933774177 0.14067959889702833 0.2668540068398031 1.3068230996261814 0.07039090929859118 0.16761101991995378 1.6992655489169033e-07 6.769738747430173 0.5241118418062065 IALALTAISLGTARPPPSMSAAGLAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IALALTAISLGTARPPPSMSAAGLAAR 27 1 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 45651600.0 39479000.0 0.0 6172600.0 False True 32828537.71624287 0.0 7463262.121122216 1.0 0.0 0.22734068101454152 24.968447153491642 -10.094529840155474 4.65107930533119 1.0000439981562266 0.11367034057996338 0.9529772990196523 0.09281144463966125 1041283823.0642836 2267059355.376115 864676.2540959151 0.033965626704149945 8.043964769758575e-11 10.094529840155474 -0.8863736575762632 IALALTAISLGTARPPPSMSAAGLAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IALALTAISLGTARPPPSMSAAGLAAR 27 1 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 197463700.0 64507700.0 89348000.0 43608000.0 False True 83506489.28686886 84375705.25679581 35671791.45586552 1.0 1.010408963151845 0.42717388505368287 26.315384977944483 -6.902837846544221 0.9431524007241466 1.022397000944684 0.36229922622951466 0.9879260619407831 0.02994482913116996 0.10934645776263678 0.16587280807275231 0.023679292802731837 0.06253475473425284 1.2507259292530708e-07 6.902837846544221 -0.6600977747151695 down IALETSLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IALETSLSK 9 0 P32942;K7EQC7 P32942 ICAM3 Intercellular adhesion molecule 3 0 7498500.0 2598200.0 1802300.0 3098000.0 False True 3406265.3610045942 1533403.8653103749 2777448.678114401 1.0 0.4501715817167383 0.815394099916884 21.699759400140053 -10.175619544469717 7.590501939554952 1.0000002029838415 0.6327828408168222 0.5740941836430513 0.14910146869411658 5.121428101672944e-07 5.569038435069994e-08 0.14436695695631596 0.04812229209561501 6.673911687082785e-11 10.175619544469717 -0.3672173621670193 IALETSLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IALETSLSK 9 0 P32942;K7EQC7 P32942 ICAM3 Intercellular adhesion molecule 3 0 7107300.0 2598200.0 1672700.0 2836400.0 False True 3558824.753714911 1598794.583120797 2166500.737491667 1.0 0.44924791012872467 0.608768592842383 21.762969461662944 -10.759447865579109 10.536794280385172 1.0013751970894809 0.5290082514856026 0.9207817285719042 0.06512404601147934 0.0021076570374986845 4.811708054598664e-05 0.06316986826063065 0.02101869547000875 1.7400115633458943e-11 10.759447865579109 -0.47236694560387826 IALHTALNNPYYYLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IALHTALNNPYYYLK 15 0 Q9UBD5-3;Q9UBD5;Q9UBD5-2 Q9UBD5-3 ORC3 Origin recognition complex subunit 3 0 15588100.0 6136300.0 6612100.0 2839700.0 False True 8044748.724013721 5625600.453763928 2545875.0843258468 1.0 0.6992885230798334 0.31646421431739236 22.939615928709095 -7.098790267233604 0.326937834887094 1.0528261783888408 3.333285171632409e-16 0.9999335313958848 0.0022805236089019306 0.07622064841625407 0.014196310847551859 0.006719800246455419 0.033947187930888266 7.965439305496851e-08 7.098790267233604 -1.0528261783888404 down IALHTALNNPYYYLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IALHTALNNPYYYLK 15 0 Q9UBD5-3;Q9UBD5;Q9UBD5-2 Q9UBD5-3 ORC3 Origin recognition complex subunit 3 0 19906800.0 6136300.0 6276900.0 7493600.0 False True 8405055.937272253 5999565.803067448 5723766.015536437 1.0 0.7138043872453425 0.6809908295975015 23.002825990231987 -13.999999999999998 0.30568667150275963 3.69778029991098 0.6733829863880427 0.9996624754209111 0.0026322334296853983 16.968463022317824 0.17576749005858167 29.04719196149266 0.011575978744561984 1.0000000000000041e-14 13.999999999999998 -3.024397313522937 IALLNVELELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IALLNVELELK 11 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 5366500.0 1830300.0 1588300.0 1947900.0 False True 1772198.1283555652 2222516.4728750815 1437686.5542525968 1.0 1.2541015800176754 0.8112448214730009 20.757108472775414 -6.751094292542764 1.6457003230387979 1.1492187438261605 0.8102864787496276 0.6536788650810936 0.1067818485529987 0.2981539305133256 1.5890677534581585 0.05124835999697411 0.12427916008171633 1.7738043167106582e-07 6.751094292542764 -0.33893226507653296 IALLNVELELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IALLNVELELK 11 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 1216210000.0 283610000.0 519750000.0 412850000.0 False True 430257104.6682978 426996551.67471445 331250016.54141676 1.0 0.9924218497307625 0.7698885455866916 28.6806237742234 -6.91413193497869 0.8671163366997713 1.006022703037416 0.7384347836752182 0.9923898148471615 0.00931110639925883 0.10174882362366061 0.12441283238376163 0.007782427450920425 0.022151025675368585 1.218619336471768e-07 6.91413193497869 -0.26758791936219783 IALLNVELELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IALLNVELELK 11 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 12023600.0 1830300.0 4123300.0 6070000.0 False True 1521975.5460381284 4101086.964489029 7339208.935491016 1.0 2.694581378238707 4.82215956399286 20.53751374820969 -6.968044879311134 0.3012461877267114 0.6364290051346594 6.947096454265022 0.9999628655890525 0.009529022029314832 0.07694233318167844 0.011288705699693995 0.03508082816286734 0.1905625809011293 1.076353979149191e-07 6.968044879311134 6.310667449130363 IALLNVELELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IALLNVELELK 11 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 741500000.0 283610000.0 142860000.0 315030000.0 False True 367138735.7888878 134909715.41596717 257697772.48076755 1.0 0.36746249377930795 0.7019084268704051 28.45175009631585 -10.6207663601113 6.6916548338207145 1.0013491057821142 0.5346854603249604 0.7207447512124728 0.13653698043703194 0.0027548692914397643 0.00015612559959495283 0.13252727187582922 0.04406712094783938 2.394603648580532e-11 10.6207663601113 -0.4666636454571538 IALTDNALIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IALTDNALIAR 11 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 41280700.0 5639700.0 14684000.0 20957000.0 False True 7393701.314932492 12493204.437783692 18788570.673739042 1.0 1.689709105850966 2.541159004596684 22.81786533314019 -6.968291934561643 0.2961566730163213 0.8454204078254931 3.411982274285256 0.9999658252688328 0.003684848202854261 0.07686092783541558 0.011003457355615342 0.014402196164183818 0.07667968455449863 1.0757418523750857e-07 6.968291934561643 2.5665618664597627 IALTDNALIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IALTDNALIAR 11 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 33364200.0 14270000.0 2828200.0 16266000.0 False True 13817006.661003089 3957515.008868166 12005446.630459864 1.0 0.2864234711587566 0.8688891107177256 23.719941765967118 -10.328503073881087 8.037445371265303 1.0000016925681687 0.577656290938579 0.4121173045599703 0.2377906016038897 7.212176767932256e-06 6.023000434341666e-07 0.23024068264486894 0.07674658665804228 4.6935011230505947e-11 10.328503073881087 -0.4223454016295898 IALTDNALIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IALTDNALIAR 11 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 32115700.0 5639700.0 13074000.0 13402000.0 False True 7724849.497161872 12496347.450063543 10236723.622854099 1.0 1.617681671941276 1.3251680342270868 22.881075394663082 -10.001923482439041 4.370758307519187 0.9999804012085696 1.471424852927819 0.775943056336161 0.11941819287755542 11977431.293384992 4568137.794160629 2252.28789955956 0.04088002396415086 9.955808114862525e-11 10.001923482439041 0.47144445171924954 IALTDNALIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IALTDNALIAR 11 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 20328300.0 14270000.0 2839800.0 3218500.0 False True 11866137.268187797 2824501.433743831 3891473.469337376 1.0 0.23803040280985982 0.3279477880110251 23.500347041401394 -10.629179234369204 6.608444905503956 1.002540839082347 0.28298909546276035 0.9883425228697388 0.036708618791356375 0.0013769942854954793 7.726744599158657e-05 0.035615538017284815 0.011847655770099986 2.3486633218463563e-11 10.629179234369204 -0.7195517436195866 IALYCHQLNICSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IALYCHQLNICSK 13 0 P35221;P35221-2;G3XAM7;P35221-3;A0A0A0MRI5;P26232-2;P26232-5;P26232-6;P26232-4;P26232 P35221 CTNNA1;CTNNA2 Catenin alpha-1;Catenin alpha-2 0 38547200.0 8729900.0 9821300.0 19996000.0 False True 11444983.44047185 8356000.323127556 17927005.735176094 1.0 0.7301015651607669 1.5663636237150382 23.44821203969872 -6.819827188412478 1.3724996381610919 0.8544929941802244 1.5845681547694395 0.8839900213386991 0.11869324387830096 0.19372219625438 0.717086063021894 0.0679559101240495 0.15664405598272385 1.514163634557273e-07 6.819827188412478 0.7300751605892151 IALYCHQLNICSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IALYCHQLNICSK 13 0 P35221;P35221-2;G3XAM7;P35221-3;A0A0A0MRI5;P26232-2;P26232-5;P26232-6;P26232-4;P26232 P35221 CTNNA1;CTNNA2 Catenin alpha-1;Catenin alpha-2 0 32476000.0 5105000.0 13169000.0 14202000.0 False True 7744658.225491562 10818889.060133372 11394968.475042267 1.0 1.3969485476483612 1.4713326454530555 22.884770143101047 -12.124231214236008 0.26941788656887106 2.0283314142425627e-10 1.4982906904727973 0.9994215461945444 0.0049760791306193725 5.542715954033137 0.15426062806827623 3.101844812161048 0.03094962147905411 7.512228436660263e-13 12.124231214236008 1.4982906902699642 IALYCHQLNICSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IALYCHQLNICSK 13 0 P35221;P35221-2;G3XAM7;P35221-3;A0A0A0MRI5;P26232-2;P26232-5;P26232-6;P26232-4;P26232 P35221 CTNNA1;CTNNA2 Catenin alpha-1;Catenin alpha-2 0 30949000.0 8729900.0 8893100.0 13326000.0 False True 11957579.946676835 8500173.436450973 10178673.257584944 1.0 0.7108606820407067 0.8512318799435439 23.511422101221612 -10.14951935107116 5.107806377054634 1.0000099142951382 0.7810462809918559 0.7643759395595683 0.05730630157513535 6.470207132005911e-06 1.0773605785203457e-06 0.055489099090412865 0.018495529302635334 7.087297265313521e-11 10.14951935107116 -0.21896363330328228 IALYCHQLNICSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IALYCHQLNICSK 13 0 P35221;P35221-2;G3XAM7;P35221-3;A0A0A0MRI5;P26232-2;P26232-5;P26232-6;P26232-4;P26232 P35221 CTNNA1;CTNNA2 Catenin alpha-1;Catenin alpha-2 0 39918000.0 5105000.0 18595000.0 16218000.0 False True 6608523.134594244 17560171.9036813 13266490.410732582 1.0 2.657200640148697 2.0074818746241903 22.655896465193496 -10.368074474908745 5.606206812426601 0.9996181346148467 2.3323412573864517 0.8486419193615342 0.26524657530770024 0.0012663234672285171 0.00014273873537567127 0.25689118180585163 0.08560796406710194 4.284750371346502e-11 10.368074474908745 1.332723122771605 IAMEK(ub)LSGHQFENYSFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAMEKLSGHQFENYSFK 17 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 13106700.0 5005900.0 2665800.0 5435000.0 True False 4846990.444591119 3730267.8419633536 4011410.4534949725 1.0 0.7696049506608901 0.8276084921874374 22.208657807686834 -9.944024425738561 5.339406182550943 1.0000004631935062 0.7986067214231856 0.9414308662574832 0.02367984667249057 1.3057655013898868e-07 2.5818869049483584e-08 0.02292796573398624 0.007642637649779896 1.1375633048003633e-10 9.944024425738561 -0.20139374177032066 IAMEK(ub)LSGHQFENYSFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAMEKLSGHQFENYSFK 17 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 41039200.0 9480600.0 5977600.0 25581000.0 True False 14382763.324700352 4910850.576798024 20524904.137449376 1.0 0.3414399907675833 1.4270487300726677 23.77783754804479 -6.742519340650594 1.6776914141971675 0.6092951424121384 1.428010868891016 0.6160697379279203 0.2766884028472065 0.3132955392602669 1.7324254109881523 0.13042530695201845 0.31914409093772805 1.8091753395611176e-07 6.742519340650594 0.8187157264788776 IAMEK(ub)LSGHQFENYSFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAMEKLSGHQFENYSFK 17 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 7238100.0 1849000.0 2445400.0 2943700.0 True False 2532625.2673461908 2337354.142143598 2248458.6874045366 1.0 0.9228977426229314 0.8877976210671633 21.27220219792005 -13.999999589085933 0.10594347416510602 1.375016345735578 0.8194775507603476 0.9997636697579327 0.0007204195687089035 12.038063839371208 0.09808230383894256 0.9734663693489642 0.0607601448802547 1.0000009461650534e-14 13.999999589085933 -0.5555387949752304 IAMEK(ub)LSGHQFENYSFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAMEKLSGHQFENYSFK 17 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 13176000.0 5005900.0 6383700.0 1786400.0 True False 4162627.648971353 6349309.741034766 2159927.9806196312 1.0 1.5253129216598977 0.5188857045989644 21.98906308312111 -6.764870547668237 1.5940284038789263 1.3032845629755134 0.5142866043121709 0.7105253757066513 0.22113197891692588 0.2748351660655906 1.3773226953687145 0.1093985788372661 0.2616649208464305 1.718420529040744e-07 6.764870547668237 -0.7889979586633425 IAMEK(ub)LSGHQFENYSFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAMEKLSGHQFENYSFK 17 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 46479200.0 9480600.0 15965200.0 21033400.0 True False 12272823.590564972 15076722.585461287 17205537.020909026 1.0 1.2284640510152758 1.4019216436987 23.54896387013724 -6.9741770474986895 0.12253508262810146 0.6996699329244358 1.9351805886434024 0.9999993946722613 0.000127929517370904 0.07496903042903853 0.0036562581064556155 0.011866652919957735 0.024650118540044653 1.0612628272398566e-07 6.9741770474986895 1.2355106557189666 IAMHSDSQTFSK(ub)DNSFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAMHSDSQTFSKDNSFR 17 1 Q9Y6W3;H7C1B7 Q9Y6W3 CAPN7 Calpain-7 1 5276100.0 1336900.0 1590300.0 2348900.0 True False 1752688.8465580142 1353033.4389408494 2105858.3602398043 1.0 0.7719758367824268 1.2015015468235308 20.741138467662505 -6.762475610599607 1.60301828404239 0.8679565772005434 1.2032718135700442 0.7010014119799453 0.09594534712057254 0.2787998432353234 1.41250814858833 0.047210618388437174 0.11318501963595154 1.727923015641184e-07 6.762475610599607 0.3353152363695008 IAMHSDSQTFSK(ub)DNSFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAMHSDSQTFSKDNSFR 17 1 Q9Y6W3;H7C1B7 Q9Y6W3 CAPN7 Calpain-7 1 5310800.0 1336900.0 1500000.0 2473900.0 True False 1831188.0583640425 1433725.0401633263 1889615.7715698213 1.0 0.782948006685996 1.0319069977214559 20.804348529185397 -6.676301976960629 1.9153627901166848 0.8622135860907559 1.0309267709285879 0.30717093712585586 0.09206733588175481 0.44676945482095354 3.1656792975214216 0.03861919646439484 0.10232805626241513 2.1071624721035586e-07 6.676301976960629 0.16871318483783193 IAMHSDSQTFSK(ub)DNSFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAMHSDSQTFSKDNSFR 17 1 Q9Y6W3;H7C1B7 Q9Y6W3 CAPN7 Calpain-7 1 14219900.0 3794500.0 3100100.0 7325300.0 True False 4912055.050777255 2927576.7097930815 5992170.563925238 1.0 0.5959983508999638 1.2198907589557801 22.22789529881042 -6.731890184861473 1.7161937227481 0.7573878788353628 1.219659196784227 0.5680567695144868 0.16980912507788345 0.3327130551337202 1.9206232052008994 0.07838041195288295 0.19409158525443826 1.8540003642733975e-07 6.731890184861473 0.4622713179488641 IAMK(ub)QYTSNIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAMKQYTSNIK 11 1 Q92503-3;Q92503;Q92503-2;K7EJ08;K7ELM0;K7EPE4 Q92503-3 SEC14L1 SEC14-like protein 1 1 4678400.0 1713200.0 1453800.0 1511400.0 True False 1658815.4037582683 2034309.9214668453 1115518.9989719063 1.0 1.2263630521261402 0.6724792863898832 20.66172191860767 -6.795750224239068 1.47330239170485 1.1255745055047202 0.6656203390980888 0.8194195130589893 0.09662275340178557 0.22687942378897766 0.9726511262195724 0.05160586267309941 0.12033482241021533 1.6004782469308204e-07 6.795750224239068 -0.45995416640663134 IANCIVHSTDKGPNSALVQQLIK(ub)DLPDEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IANCIVHSTDKGPNSALVQQLIKDLPDEVR 30 2 H7BXH2;E9PKF6;Q5H9R7-3;Q5H9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7;Q5H9R7-5;E9PQP7;H0YEN2;H0YDW1 H7BXH2 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 36145600.0 8980600.0 11013000.0 16152000.0 True False 13624226.769804023 9047644.105038268 12959550.12032692 1.0 0.6640849611437004 0.9512136240311079 23.69967101762226 -10.110721890366143 7.056579463620056 1.0000001020544467 0.8076492937718284 0.3743644670234205 0.11721978576695902 1.8818174681719236e-07 2.3727287786582783e-08 0.11349763041491027 0.03783252317678612 7.749578995813347e-11 10.110721890366143 -0.1923508082826183 IANCIVHSTDKGPNSALVQQLIK(ub)DLPDEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IANCIVHSTDKGPNSALVQQLIKDLPDEVR 30 2 H7BXH2;E9PKF6;Q5H9R7-3;Q5H9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7;Q5H9R7-5;E9PQP7;H0YEN2;H0YDW1 H7BXH2 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 34588600.0 8980600.0 11630000.0 13978000.0 True False 11625563.734091496 10982780.276408358 11434147.426391674 1.0 0.9447094805563534 0.9835348795053696 23.47079733971471 -9.970144365022234 4.5270500592890235 1.0000007809404738 0.964122180027661 0.5323973467787508 0.015850402765166267 1.249341068599458e-07 2.8416604609080423e-08 0.015347420484823284 0.005115695492532103 1.0711631777545978e-10 9.970144365022234 -0.03587860091281281 IANK(ub)QFTAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IANKQFTAVK 10 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 6184800.0 1705100.0 1308300.0 3171400.0 True False 2207285.562545866 1235491.9549118702 2594237.7413119595 1.0 0.5597336275270444 1.1753068045802764 21.07384185640349 -6.714720274043085 1.7785829827032542 0.7306472263332939 1.1740589784031275 0.4874177540699903 0.1853950726210154 0.3656538504782937 2.2575998858239488 0.08286648699280634 0.20930760054536995 1.9287668180531006e-07 6.714720274043085 0.4434117520698335 IANPVEGSSGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IANPVEGSSGR 11 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 8770780.0 2051800.0 877980.0 5841000.0 False True 1986666.7320985377 1228561.9926052147 4311066.873756049 1.0 0.618403667185523 2.170000032769574 20.921918446806345 -6.841655329282276 1.2746380838644822 0.7970164753891221 2.222741443689671 0.9272636717139919 0.17803541709427326 0.16688048534194172 0.525950284352708 0.10949006902728606 0.25237362149141007 1.4399409104693364e-07 6.841655329282276 1.4257249683005488 up IAPAEAPDAK(ub)VR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAPAEAPDAKVR 12 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 60426770.0 17005900.0 28077800.0 15343070.0 True False 22294899.585369885 23888701.68640718 13755516.29751991 1.0 1.0714872966767324 0.6169804104678006 24.410210366082904 -6.866678349906542 1.151435185416002 1.039726932809648 0.591980381433571 0.9612588310198609 0.039277480166537496 0.14008427082736785 0.34918835919265456 0.026522053885793158 0.062458507772018314 1.359319822435147e-07 6.866678349906542 -0.4477465513760769 IAPAEAPDAK(ub)VR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAPAEAPDAKVR 12 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 128293200.0 35569300.0 48950500.0 43773400.0 True False 34440172.04115041 68496689.92348531 32307833.366148476 1.0 1.9888602717095283 0.9380857136121695 25.037589013749272 -6.659869453417598 1.9732513742898794 1.6365893138121024 0.9424632706949242 0.235050664283604 0.42104833356057525 0.4847823931243777 3.628484613146764 0.1723956717967212 0.4667750570795162 2.1884193521615227e-07 6.659869453417598 -0.6941260431171782 IAPAEAPDAK(ub)VR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAPAEAPDAKVR 12 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 170557100.0 57098600.0 59461400.0 53997100.0 True False 86622750.6668076 48850048.59596137 43324549.51723028 1.0 0.5639401683728786 0.5001520868793136 26.368242649481886 -13.999999999999998 0.27070731896327405 4.3784867823734395 0.4791232329817342 0.9995848505207965 0.004525889317609985 14.917822048698875 0.16471083841304376 27.74865817593591 0.026399210454216532 1.0000000000000041e-14 13.999999999999998 -3.899363549391705 IAPAEAPDAK(ub)VR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAPAEAPDAKVR 12 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 55118600.0 17005900.0 21965900.0 16146800.0 True False 23293440.797167428 20995373.90648239 12333258.393784547 1.0 0.9013427466257158 0.529473447103801 24.473420427605795 -6.946240663649168 0.5986960011149701 1.0042008566675766 0.4076218068012872 0.9988722646112372 0.006803613170602186 0.0850313597010704 0.04248719528088315 0.006991838707455264 0.031237737150868437 1.1317730190747427e-07 6.946240663649168 -0.5965790498662895 IAPAEAPDAK(ub)VR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAPAEAPDAKVR 12 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 111316000.0 35569300.0 57105800.0 18640900.0 True False 29577448.93716549 56798159.72078614 22538626.004216574 1.0 1.9203197625815698 0.7620206209162178 24.81799428918355 -6.695017919044523 1.8488316136063725 1.5742494155611562 0.7657894470700038 0.3939326378965162 0.38884310675764505 0.405951610505929 2.6941270489879 0.16802274436408968 0.43475610311635493 2.0182830873515118e-07 6.695017919044523 -0.8084599684911523 IAPAEAPDAK(ub)VR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAPAEAPDAKVR 12 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 169022800.0 57098600.0 85838400.0 26085800.0 True False 73915263.28167349 81061417.5819822 21338452.062910855 1.0 1.096680360497079 0.28868803431836654 26.139368971574335 -6.877016473412214 1.0962492815660003 1.0578596817584816 0.23459200639223557 0.9712005886632719 0.061139565370225676 0.13030831803883894 0.2885049781568229 0.043069575434191563 0.10341265579852502 1.32734410871019e-07 6.877016473412214 -0.823267675366246 down IAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAPAFSSMSNKYPQAVFLEVDVHQCQGTAATNNISATPTFLFFR 44 1 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 0 186807000.0 42047000.0 64122000.0 80638000.0 False True 63788373.04745222 52678928.11252734 64699863.95510904 1.0 0.8258390298391753 1.0142892954328646 25.92679014658048 -13.908336258171984 13.582995907442367 8.935605097586976 0.9280577532681666 0.0 0.08767408045022711 0.0 0.0 0.0 0.025509695207658906 1.2349908553791676e-14 13.908336258171984 -8.007547344318809 IAPELYHK(ub)MLVVGGIDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAPELYHKMLVVGGIDR 17 1 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 1 8276100.0 3100800.0 1935900.0 3239400.0 True False 3002366.8012921065 2708914.9655851354 2390903.960083095 1.0 0.9022598319496871 0.7963397273957796 21.51766881213171 -6.970098528575481 0.25583653644650245 1.0312902830620418 0.6641837891722487 0.9999831317112147 0.00034152374006005516 0.07627088162065584 0.008916385486246658 0.0022720105973811086 0.010057443166240274 1.0712762367665652e-07 6.970098528575481 -0.3671064938897931 IAPELYHK(ub)MLVVGGIDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAPELYHKMLVVGGIDR 17 1 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 1 20315100.0 4553000.0 6902200.0 8859900.0 True False 6907233.868886011 5670448.482865262 7108736.88156788 1.0 0.8209434616667735 1.0291727508445239 22.719676641355083 -6.679112942702483 1.9048163676125283 0.8866209382914266 1.0283792588467793 0.32017925848332285 0.0759027916876724 0.4404895169983505 3.0892055387020028 0.03198171076688677 0.08445248882956198 2.0935679313898263e-07 6.679112942702483 0.14175832055535265 IAPELYHK(ub)MLVVGGIDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAPELYHKMLVVGGIDR 17 1 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 1 9106600.0 3100800.0 2238800.0 3767000.0 True False 2578452.5887313737 2226739.1400329918 4554662.283359912 1.0 0.8635951460827795 1.7664324344241114 21.298074087565986 -6.868410980108336 1.1425448814439843 0.9235563277780974 1.8177173760388883 0.9630673654522147 0.07636640387772244 0.13838349211646775 0.33863144065910683 0.05192298541466019 0.12259519380768659 1.3539075806228301e-07 6.868410980108336 0.8941610482607909 IAPELYHK(ub)MLVVGGIDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAPELYHKMLVVGGIDR 17 1 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 1 18644800.0 4553000.0 6659800.0 7432000.0 True False 5893948.253047521 6289176.275565303 6079452.258759682 1.0 1.06705658169181 1.0314736400368367 22.490802963447532 -10.09431239457272 3.939889426334255 0.9999871118558145 1.0492651108503037 0.7187726041158489 0.014526675215150872 5053063.533826966 0.008845866140959032 610.2163050788236 0.004972867296425642 8.047993286433191e-11 10.09431239457272 0.04927799899448926 IAPLVK(ub)SLCAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAPLVKSLCAK 11 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 36763600.0 2491700.0 5147900.0 29124000.0 True False 3266642.829657127 4379853.386357029 26110527.857134856 1.0 1.340781228542438 7.993077057608856 21.639377290383642 -6.917525592174494 0.8428690344992321 0.8397264719473291 9.007073967290836 0.9934656196943746 0.26022995584583225 0.09964984848330322 0.113318086378952 0.22132487217807728 0.6480767614074878 1.2091339288067938e-07 6.917525592174494 8.167347495343506 up IAPLVK(ub)SLCAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAPLVKSLCAK 11 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 30046300.0 0.0 2695300.0 27351000.0 True False 0.0 3771547.3458038126 20186952.58758804 0.0 IAPLVK(ub)SLCAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAPLVKSLCAK 11 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 197109300.0 4013300.0 59666000.0 133430000.0 True False 6088469.511530911 49018136.12741426 107057502.01555343 1.0 8.050978334469631 17.58364755096465 22.53764818569508 -7.0646670422907345 0.34416600881808296 5.4785205945152714e-21 25.02843896174581 0.9999198413237528 0.0608407592991645 0.07962618122397563 0.015569990051084783 0.15672600071022813 0.8606677508801367 8.616540977309813e-08 7.0646670422907345 25.02843896174581 IAPLVK(ub)SLCAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAPLVKSLCAK 11 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 90503000.0 2491700.0 3148300.0 84863000.0 True False 3412948.8256606283 3009197.6959641315 64820107.20834693 1.0 0.8817002099003507 18.992405254069407 21.702587351906534 -6.905428348024214 0.9263079321322629 0.3550195816608656 21.11771809006629 0.9890790762959505 0.8892933535606541 0.1075188642240768 0.15574036546902953 0.7120063297329441 1.9084411759381297 1.2432877424683101e-07 6.905428348024214 20.762698508405425 up IAPLVK(ub)SLCAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAPLVKSLCAK 11 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 45272000.0 0.0 2628000.0 42644000.0 True False 0.0 2613842.4423828423 51560663.23642159 0.0 IAPLVK(ub)SLCAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAPLVKSLCAK 11 1 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 126441300.0 4013300.0 53441000.0 68987000.0 True False 5195295.963970047 50466961.37158548 56432073.866395995 1.0 9.713972355295915 10.862148038871831 22.30877450778753 -9.442081320596877 0.6242611785142566 1.030815604879087e-17 10.731109024550568 0.9986761570114263 0.16021811048325102 0.7796915066495929 0.2844337064691478 2.232021778111633 0.19241185526624083 3.613421958477616e-10 9.442081320596877 10.731109024550568 IAPPEAPVTGYMFGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAPPEAPVTGYMFGK 15 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 14400950.0 906950.0 7571000.0 5923000.0 False True 1189020.232916294 6441436.311526855 5310144.777427892 1.0 5.41743204464068 4.4659835303254445 20.181341834180362 -10.14231421797609 5.799950028765134 0.9999582025626249 4.941707787483233 0.9581314340586219 0.3884272294341818 0.00020993687892480222 3.104444759791361e-05 0.3760969182052484 0.12536434923425124 7.205859367889443e-11 10.14231421797609 3.9417495849206086 IAPPEAPVTGYMFGK(ub)GIYFADMVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAPPEAPVTGYMFGKGIYFADMVSK 25 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 26276300.0 5360700.0 4399600.0 16516000.0 True False 6939531.825194791 4154758.3924407787 13510257.468470799 1.0 0.5987087453589357 1.9468543136325438 22.726406904137328 -6.826937690670592 1.3415084823497492 0.7850815868562706 1.9809226665967434 0.8996186391423848 0.17907256761431653 0.18461806668986058 0.6508521182626669 0.10483902422497413 0.24131985393794028 1.4895747754468712e-07 6.826937690670592 1.1958410797404728 IAQGVSGSIQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAQGVSGSIQDK 12 0 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 9664200.0 1940600.0 3447600.0 4276000.0 False True 2544145.392797133 2933231.518639547 3833560.53828831 1.0 1.1529339191635732 1.5068166108516086 21.27874968942509 -6.957096657903902 0.4745846240335967 0.9910575123347992 1.6833130262781162 0.9996469028050223 0.003988528727685619 0.08075501870639809 0.025090594105076806 0.004936154023397741 0.029199431820289796 1.1038329201413424e-07 6.957096657903902 0.692255513943317 IAQGVSGSIQDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAQGVSGSIQDK 12 0 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 8842170.0 2030100.0 977670.0 5834400.0 False True 1965655.5867205565 1368058.7294816985 4306195.611751814 1.0 0.6959808924431815 2.1907172552726535 20.90657913064735 -6.853745892339988 1.2169255936540613 0.837091472189179 2.254914406055592 0.945573886465657 0.1504796249016702 0.1533858496748929 0.4352419078289502 0.09666034347067767 0.22427401250616696 1.4004064670463317e-07 6.853745892339988 1.4178229338664132 up IAQGVSGSIQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAQGVSGSIQDK 12 0 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 7837000.0 1940600.0 2449200.0 3447200.0 False True 2658092.2627431112 2340986.245578677 2633042.3573125387 1.0 0.8807016514779717 0.9905759834669089 21.341959750947982 -10.411627029465588 5.634677751573417 1.000031140827467 0.9356388175037637 0.31389522327626973 0.0448560082003432 1.7556312996641483e-05 1.8332239561846445e-06 0.04345265069942099 0.014477214394772609 3.8759036323830266e-11 10.411627029465588 -0.06439232332370326 IAQGVSGSIQDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAQGVSGSIQDK 12 0 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 3866100.0 2030100.0 1199400.0 636600.0 False True 1688118.0986789083 1192938.594137739 769710.1166941662 1.0 0.7066677355519805 0.4559575051630143 20.686984406081628 -7.113697553530571 0.18500673502320625 1.19094032544242 2.0566765193190953e-14 0.9999950475872441 0.0004947432189874581 0.07819624854240778 0.006842112086195297 0.011426980070134058 0.030511577069780683 7.696662559929362e-08 7.113697553530571 -1.1909403254423994 down IAQLEEELEEEQGNTELINDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAQLEEELEEEQGNTELINDR 21 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 15025900.0 3918600.0 2008200.0 9099100.0 False True 3794206.1879331917 2810084.7326246514 6715772.74285118 1.0 0.7406252041762079 1.7700073243803984 21.855366650347147 -6.839955087819041 1.2827480683578198 0.8620242589812731 1.8038035836841437 0.9243533740280605 0.12023039674971084 0.1688525593205302 0.5397440504081736 0.07349920740130965 0.16931218414906513 1.4455892573548568e-07 6.839955087819041 0.9417793247028706 IAQLICER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAQLICER 8 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YKC5;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 36728900.0 2092900.0 18364000.0 16272000.0 False True 2743812.167672433 15624162.782311331 14588329.532045702 1.0 5.694326662150951 5.31681056885936 21.387750292073 -10.274654369901864 4.565832706976785 0.9978024298317159 5.505568615527369 0.9947621597910571 0.15412029978460556 0.0034474552450141243 0.0005476745857222565 0.1492174661718425 0.04974211285419279 5.3130711291324893e-11 10.274654369901864 4.507766185695653 IAQLICER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAQLICER 8 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YKC5;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 11586700.0 6912900.0 1277700.0 3396100.0 False True 6693453.773430151 1787892.2731174775 2506559.529183864 1.0 0.26711057305192204 0.37447924704189656 22.674319392455427 -10.48619167623314 6.809348225112168 1.0002154274964252 0.3207949100469093 0.9816028563332981 0.04383307760577893 0.00014339806623078915 1.0820256043930293e-05 0.04245416924643614 0.014147064965016604 3.264437241626511e-11 10.48619167623314 -0.6794205174495159 IAQLICER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAQLICER 8 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YKC5;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 46447900.0 2092900.0 22362000.0 21993000.0 False True 2866701.688495858 21373972.89875487 16798706.360052988 1.0 7.455945969030935 5.859942256101008 21.450960353595892 -10.47256374327844 6.728096883799406 0.9984003816724536 6.657944112565971 0.9436831993331494 0.6515657873776207 0.015628715185852946 0.0012251834245166837 0.6306645474160039 0.21029195362267056 3.3684977121595884e-11 10.47256374327844 5.6595437308935175 IAQPGDHVSVTGIFLPILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAQPGDHVSVTGIFLPILR 19 0 P33993;P33993-3;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 40898000.0 11247000.0 19416000.0 10235000.0 False True 14744925.916102938 16519208.482975245 9175980.381052576 1.0 1.1203317383191875 0.6223144445257256 23.813715238002207 -6.842884501203332 1.268938043422864 1.0640089738294358 0.6049770362322283 0.9293003338625514 0.05641491209270283 0.1654561155355277 0.5162691154551534 0.034843550795195785 0.08034548238735818 1.435871246518674e-07 6.842884501203332 -0.4590319375972075 IAQPGDHVSVTGIFLPILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAQPGDHVSVTGIFLPILR 19 0 P33993;P33993-3;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 82228000.0 34926000.0 20233000.0 27069000.0 False True 33817293.24752583 28312142.41370113 19978816.84740672 1.0 0.8372090044720691 0.5907869888098872 25.011257854573063 -6.965105393712778 0.3562401492328362 1.0221673964836626 0.3974331026722947 0.999915298971986 0.0015481658824136883 0.07792523138712802 0.014734022715346786 0.0033326255057138502 0.021095887010979322 1.0836639007293603e-07 6.965105393712778 -0.6247342938113679 IAQPGDHVSVTGIFLPILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAQPGDHVSVTGIFLPILR 19 0 P33993;P33993-3;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 115007000.0 24197000.0 53085000.0 37725000.0 False True 36708618.03765312 43611566.99500191 30268637.214545146 1.0 1.1880470942890913 0.8245648796557176 25.129615466806086 -6.76607077059049 1.5892840069302292 1.1083967070475154 0.8228065511929707 0.715404797516944 0.07917871557625988 0.2728199086044785 1.359281970776139 0.03928266069273793 0.09385811758810048 1.7136780318250807e-07 6.76607077059049 -0.2855901558545446 IAQPGDHVSVTGIFLPILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAQPGDHVSVTGIFLPILR 19 0 P33993;P33993-3;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 133506810.0 11247000.0 22129510.0 100130300.0 False True 15405319.838746665 21151755.075696487 76481585.38826044 1.0 1.373016288989774 4.964621714370247 23.876925299525098 -6.92682111923706 0.7724393058442489 0.9384640091685519 5.6456206100440545 0.9958757163158736 0.11479547474497735 0.09432250710226851 0.08601519348118553 0.10267013881806772 0.3308408828333435 1.1835289369226379e-07 6.92682111923706 4.707156600875503 up IAQPGDHVSVTGIFLPILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAQPGDHVSVTGIFLPILR 19 0 P33993;P33993-3;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 75749100.0 34926000.0 12827000.0 27996100.0 False True 29042516.484143432 12757898.405039849 33849955.07065901 1.0 0.43928350396238486 1.1655310616468215 24.79166313000734 -6.700504575084118 1.8288589530443613 0.6519972080649624 1.1634073863599417 0.4200872957543751 0.23666261970119212 0.3944642462976157 2.5653550529177496 0.10321783535240237 0.2653046426545391 1.9929455113288112e-07 6.700504575084118 0.5114101782949793 IAQPGDHVSVTGIFLPILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAQPGDHVSVTGIFLPILR 19 0 P33993;P33993-3;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 74374000.0 24197000.0 27118000.0 23059000.0 False True 31323493.49417763 25608859.461362146 18862498.6053202 1.0 0.8175607700374253 0.6021837445694344 24.900741788898536 -6.968931446694943 0.28254629637531287 1.0460172554669145 0.3671413356773403 0.9999728047916737 0.0008478883370678532 0.07665098623512907 0.010265654280919724 0.003920816542318166 0.019706162571749 1.0741589547556067e-07 6.968931446694943 -0.6788759197895742 IASLEVENQSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IASLEVENQSLR 12 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-3;E9PL71;E9PN91 E9PI39;P29692;P29692-3 EEF1D Elongation factor 1-delta 0 104301900.0 27530000.0 48224000.0 28547900.0 False True 36092096.60089925 41029167.175679706 25594037.15879345 1.0 1.1367909054819898 0.7091313492205317 25.105179616475883 -6.820645854342136 1.369077160120315 1.073681276912015 0.6996648716277745 0.8858655815419834 0.06024606928339131 0.19264117643347967 0.7093287134773139 0.03457870240543816 0.07968495505701843 1.5113120520074462e-07 6.820645854342136 -0.3740164052842405 IASLEVENQSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IASLEVENQSLR 12 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-3;E9PL71;E9PN91 E9PI39;P29692;P29692-3 EEF1D Elongation factor 1-delta 0 57641000.0 24237000.0 0.0 33404000.0 False True 23467609.70166303 0.0 24654490.301480453 1.0 0.0 1.0505752658624332 24.484167567547974 -10.516547736648336 5.033459381243937 1.0017498193534458 0.525287632931205 0.21398228430289756 0.42889555629199866 0.00844950070236244 0.000811554571076612 0.4166344421031601 0.13842544556510034 3.044053376302776e-11 10.516547736648336 -0.4764621864222408 IASLLGLLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IASLLGLLSK 10 0 Q96HW7;Q96HW7-2;F8WAA7 Q96HW7 INTS4 Integrator complex subunit 4 0 4212210.0 712110.0 1023800.0 2476300.0 False True 933583.1060830507 871053.0307411428 2220076.230346899 1.0 0.9330214150893757 2.378016714185703 19.832418929022428 -6.896033211515745 0.9860231962803804 0.933210476315615 2.518036173146309 0.9844867362576404 0.08294581157757491 0.11438373814285005 0.19435200716970075 0.06353353488140988 0.16224414091339398 1.2704769451472878e-07 6.896033211515745 1.5848256968306937 up IASLLGLLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IASLLGLLSK 10 0 Q96HW7;Q96HW7-2;F8WAA7 Q96HW7 INTS4 Integrator complex subunit 4 0 1853900.0 1048500.0 805400.0 0.0 False True 1015215.941419884 1127000.420105515 0.0 1.0 1.1101090655937582 0.0 19.953355197700585 -6.955010224330394 1.1951486794454995 1.0633316031129663 1.4650950740404116e-19 0.9734617116981743 0.08135265434231242 0.10561707842111483 0.2994451120167878 0.05668632974356751 0.10728788501480226 1.1091487029428634e-07 6.955010224330394 -1.0633316031129663 down IASLLGLLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IASLLGLLSK 10 0 Q96HW7;Q96HW7-2;F8WAA7 Q96HW7 INTS4 Integrator complex subunit 4 0 4733910.0 712110.0 1552500.0 2469300.0 False True 975396.3110491595 1483905.4165690395 1886102.196829848 1.0 1.5213358916366164 1.933677804051885 19.89562899054532 -6.973767262562014 0.14175331376687578 0.4614046735411631 3.004379742061117 0.9999988643389921 0.0004070860679570259 0.07509812257899719 0.004299599882921603 0.022885347586930723 0.05327896592521494 1.0622646699441272e-07 6.973767262562014 2.542975068519954 IASLLGLLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IASLLGLLSK 10 0 Q96HW7;Q96HW7-2;F8WAA7 Q96HW7 INTS4 Integrator complex subunit 4 0 2557630.0 1048500.0 832180.0 676950.0 False True 871874.206425712 827696.8811652033 818497.1151368439 1.0 0.9493306202489742 0.9387789076732871 19.73376047313486 -13.999999999999982 0.2205415069370835 1.306488694712139 0.9331639761815552 0.9994983943739856 0.0005984602944716495 13.014262607233833 0.14876621665637993 1.73763196979163 0.0058187313260226825 1.0000000000000409e-14 13.999999999999982 -0.3733247185305838 IASLLLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IASLLLAK 8 0 F8VWT9;J3KPF0;Q9Y4D8-4;Q9Y4D8;Q9Y4D8-2 F8VWT9 HECTD4 Probable E3 ubiquitin-protein ligase HECTD4 0 7863500.0 2379500.0 1849400.0 3634600.0 False True 3119547.543110782 1573476.7289047367 3258526.4575450644 1.0 0.5043926105180244 1.0445509845622338 21.572905366153453 -6.665457534013456 1.953823859056977 0.6824185129339232 1.042312049470028 0.25890644646964445 0.21074811874946947 0.47165285776814514 3.466770737211771 0.08698073590284747 0.23374641681753375 2.1604412757382298e-07 6.665457534013456 0.3598935365361048 IASLLLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IASLLLAK 8 0 F8VWT9;J3KPF0;Q9Y4D8-4;Q9Y4D8;Q9Y4D8-2 F8VWT9 HECTD4 Probable E3 ubiquitin-protein ligase HECTD4 0 6007900.0 2379500.0 1698500.0 1929900.0 False True 3259265.4535696376 1623454.6538116059 1474097.3675381371 1.0 0.4981044584857467 0.45227901456251896 21.636115427676344 -13.999999999999996 0.3387072708376776 6.759388192395707 0.44496790818722537 0.9997326171432204 0.004056943337685969 19.58595194686386 0.18660694704340733 80.71412851559283 0.014224119056882532 1.0000000000000082e-14 13.999999999999996 -6.314420284208482 IASPEGQDYLK(ub)GMAAAGNYAWVNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IASPEGQDYLKGMAAAGNYAWVNR 24 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 19273000.0 3793200.0 4085800.0 11394000.0 True False 3672786.9422927042 5717281.2471655235 8409569.58732691 1.0 1.5566601975546563 2.2896970936400987 21.808443777342283 -6.9673307977237355 0.3154980284880349 0.8941568008449341 2.9756886680229586 0.9999534452997292 0.0036036521119278834 0.07717867407888056 0.012115926627500946 0.011321382772898859 0.06474232348159781 1.0781252123084347e-07 6.9673307977237355 2.0815318671780245 IASPEGQDYLK(ub)GMAAAGNYAWVNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IASPEGQDYLKGMAAAGNYAWVNR 24 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 15917400.0 3793200.0 4187000.0 7937200.0 True False 3154213.8672522726 4164443.7999455724 9596831.822533667 1.0 1.32027946588585 3.042543158588592 21.58884905277656 -6.9381957483726575 0.6761383434978421 0.979932067387609 3.4833297409204937 0.997917930778226 0.04092778214213493 0.08859943652459772 0.05843038200962776 0.03931526868082894 0.14944843537320446 1.1529334821133291e-07 6.9381957483726575 2.5033976735328847 up IASPEGQDYLK(ub)GMAAAGNYAWVNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IASPEGQDYLKGMAAAGNYAWVNR 24 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 56773400.0 6862100.0 9062300.0 40849000.0 True False 8883123.722213356 8557975.038598059 33414901.146134883 1.0 0.9633970330952137 3.7616160926112925 23.082635654243184 -6.9039361039253535 0.9360359201192948 0.8958879217393121 4.080004337850652 0.9884251974496043 0.14099726572318186 0.1085661125469567 0.16152511764721947 0.11208164211319428 0.29782416534971584 1.2475670504768557e-07 6.9039361039253535 3.18411641611134 up IASWADLVNAHVVPGSGVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IASWADLVNAHVVPGSGVVK 20 0 P11172;P11172-3;P11172-2 P11172 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 0 16702500.0 3422500.0 6661300.0 6618700.0 False True 4486930.643537146 5667460.005544024 5933860.415053519 1.0 1.2631039915242015 1.3224765182409253 22.09729745313822 -13.023155041302456 0.22269247626570554 9.54083353408463e-19 1.3546560996268568 0.9994472793441669 0.003294566238426786 8.443824275742426 0.1439126791393026 3.7511739449337553 0.0322749787345948 9.480799423294785e-14 13.023155041302456 1.3546560996268568 IASWADLVNAHVVPGSGVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IASWADLVNAHVVPGSGVVK 20 0 P11172;P11172-3;P11172-2 P11172 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 0 18767000.0 7209500.0 3295500.0 8262000.0 False True 6980638.368780782 4611410.335805466 6097934.345312874 1.0 0.6606000901620809 0.873549670268612 22.734927544063154 -10.372462110141448 5.997445176460813 1.0000401413742812 0.7670748802153463 0.6146747004526547 0.08693630203348932 4.666983449588054e-05 4.88325756830605e-06 0.08419019329991201 0.028058570829713407 4.241679886726939e-11 10.372462110141448 -0.2329652611589349 IASWADLVNAHVVPGSGVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IASWADLVNAHVVPGSGVVK 20 0 P11172;P11172-3;P11172-2 P11172 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 0 19063900.0 3422500.0 6596700.0 9044700.0 False True 4687890.739584818 6305235.981630276 6908528.1414437005 1.0 1.3450048927950693 1.4736964927760994 22.160507514661113 -12.338556841713581 0.15849550099819895 4.411671251868977e-12 1.6143284802199425 0.9995490808729729 0.004246839189921625 6.278177099921235 0.11029163725514907 2.1397895809194245 0.11557270418992213 4.586096177213214e-13 12.338556841713581 1.6143284802155309 IASWADLVNAHVVPGSGVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IASWADLVNAHVVPGSGVVK 20 0 P11172;P11172-3;P11172-2 P11172 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 0 14051400.0 7209500.0 2634100.0 4207800.0 False True 5995018.685003499 2619909.5804720884 5087631.525330994 1.0 0.4370144144881109 0.8486431473612706 22.51533281949743 -9.744015039218779 5.983256518200512 1.0000000109143086 0.6428287809231976 0.5009672479681653 0.16804672650663044 2.4385067454888795e-08 5.26794900438828e-09 0.16271054813300856 0.05423684776128674 1.8029553050932838e-10 9.744015039218779 -0.35717122999111095 IATDDSK(ub)AVCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IATDDSKAVCR 11 1 P11926 P11926 ODC1 Ornithine decarboxylase 1 16764900.0 1523700.0 4986200.0 10255000.0 True False 2311564.2973910873 4096373.652641589 8228094.755073824 1.0 1.7721218731682697 3.5595353174299937 21.140438061786476 -6.957088476929264 0.4746987335661026 0.9548820148364678 4.4506319712248485 0.9996464800764631 0.020155472406608456 0.0807581705205738 0.025103017803408765 0.024937383382886043 0.14748125744262433 1.103853713668675e-07 6.957088476929264 3.495749956388381 IATEK(ub)DFLEAVNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IATEKDFLEAVNK 13 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 21184700.0 4155400.0 7719000.0 9310300.0 True False 5447769.640950841 6567355.28842634 8346959.466703853 1.0 1.2055126632116715 1.5321792250464896 22.377234269575002 -6.964276219661892 0.37026836901895077 0.9749554046664363 1.774111969150052 0.9998974328843252 0.002219239869329267 0.07820748413296386 0.015731527559421747 0.004303960519424297 0.027739576227089887 1.0857348556728013e-07 6.964276219661892 0.7991565644836157 IATEK(ub)DFLEAVNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IATEKDFLEAVNK 13 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 37499300.0 5884300.0 13350000.0 18265000.0 True False 5697506.117402973 18680724.619330317 13480848.561745292 1.0 3.2787546400819543 2.3660963733883813 22.441899137834877 -10.47083761211053 6.176935634987017 0.9990181549442808 2.8224255067350854 0.8416832820274267 0.372591177155364 0.005039689846309713 0.00043173711118893915 0.3608833291270229 0.12025328533887841 3.381912663179519e-11 10.47083761211053 1.8234073517908045 IATEK(ub)DFLEAVNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IATEKDFLEAVNK 13 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 94831000.0 9868000.0 25672000.0 59291000.0 True False 14970477.447434051 21090631.023748484 47572107.86183155 1.0 1.4088148556252913 3.177728167245958 23.835616897636008 -6.943073790070303 0.6303180784774515 0.9807038729239398 3.7012261155853925 0.9985394370281857 0.03611863737030527 0.08639189326527473 0.04843082154561677 0.03603924721675515 0.15030721234154926 1.1400560665540029e-07 6.943073790070303 2.7205222426614526 up IATEK(ub)DFLEAVNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IATEKDFLEAVNK 13 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 18155500.0 4155400.0 6531800.0 7468300.0 True False 5691763.675462599 6243203.4782258645 5704441.354466591 1.0 1.0968838191825396 1.0022273726962077 22.440444331097893 -6.640898995197495 2.0427954881380095 1.063318214521355 1.0026334230387308 0.15757560018066652 0.041445499291487525 0.5310235505881544 4.236898955533562 0.016522158263805212 0.04585037018786788 2.28613043182763e-07 6.640898995197495 -0.06068479148262429 IATEK(ub)DFLEAVNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IATEKDFLEAVNK 13 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 31230400.0 5884300.0 16348000.0 8998100.0 True False 4893056.168689377 16259930.079176087 10879561.107486295 1.0 3.323062216866268 2.223469490725349 22.222304413269153 -10.465223625244947 6.115467782252322 0.9990485940215007 2.7732658537958037 0.7761636653358659 0.44890685065352937 0.005825165622187662 0.0005093896417747814 0.43480675876402 0.14488406304829476 3.4259133530829087e-11 10.465223625244947 1.7742172597743031 IATEK(ub)DFLEAVNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IATEKDFLEAVNK 13 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 81573000.0 9868000.0 23389000.0 48316000.0 True False 12774320.527360642 22087381.589416612 39522983.76402493 1.0 1.729045512996861 3.0939401966134117 23.606743219728457 -6.961315803231141 0.4164751274852648 0.9373303043538292 3.9368462225209413 0.9998159289510427 0.01177484577631094 0.0792343999636142 0.019419045074615567 0.017620378563501172 0.1137312163683602 1.0931611699442926e-07 6.961315803231141 2.999515918167112 IATEKDFLEAVNK(ub)VIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IATEKDFLEAVNKVIK 16 2 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 5030170.0 1328000.0 1835670.0 1866500.0 True False 1285843.3669104488 2568662.60389259 1377607.6562002515 1.0 1.9976481350636246 1.0713650602019194 20.294283482950917 -6.628557369505433 2.085258700048484 1.6579344175074733 1.0750349327736304 0.11249023059055929 0.4280892707691588 0.5627519230693567 4.661104115975 0.1679996256829014 0.47439135248324715 2.3520287741745206e-07 6.628557369505433 -0.5828994847338429 IATGSFLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 IATGSFLKR 9 1 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 12550300.0 2016700.0 2529200.0 8004400.0 True False 3059481.340518871 2077844.499270205 6422326.831546843 1.0 0.6791492635538722 2.099155417779947 21.544855669665996 -6.847340965780447 1.2478770704676125 0.8291009773035565 2.1530703135251343 0.9363482619036377 0.1534063217379144 0.16040085854499242 0.4819974651393644 0.09625966736771674 0.22240201080324315 1.4212125511559382e-07 6.847340965780447 1.3239693362215779 up IATTTASAATAAAIGATPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IATTTASAATAAAIGATPR 19 0 Q14980;Q14980-2;A0A087WY61;Q14980-5;H0YFY6 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 0 1358100.0 0.0 0.0 1358100.0 False True 0.0 0.0 1217576.839815096 0.0 IAVEAQNK(ub)YER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAVEAQNKYER 11 1 P12270 P12270 TPR Nucleoprotein TPR 1 2000910.0 578540.0 903340.0 519030.0 True False 481081.64366765047 898473.5281210494 627556.7732764254 1.0 1.8676113294851657 1.3044704189752157 18.875922226891902 -10.105234904405174 4.551162131224426 0.99996116677045 1.5860408742467533 0.5908309119350844 0.22990131415312695 160114127.0798422 9.402164381125516 83265.82198682231 0.078701334828239 7.84811025406935e-11 10.105234904405174 0.5860797074763033 IAVEAQNKYER ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAVEAQNKYER 11 1 P12270 P12270 TPR Nucleoprotein TPR 0 9740560.0 250160.0 6247600.0 3242800.0 False True 379511.00914573314 5132666.967278404 2601859.1586302663 1.0 13.524421804869032 6.855819978679844 18.533782211486198 -9.134160318312794 12.266509746296839 1.0000138324097474 10.19012089177445 0.7168966821483722 2.7224452953376903 0.0 0.0 2.6359963224455885 0.8786654408151959 7.342427749311319e-10 9.134160318312794 9.190107059364703 IAVHCTVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAVHCTVR 8 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 12862600.0 3659900.0 4236600.0 4966100.0 False True 4798164.342522011 3604515.7941374537 4452255.610194946 1.0 0.7512280815798085 0.9279081107619485 22.194051141728565 -9.920531991909897 5.491915156375665 1.0000001892099426 0.8395680963903076 0.5236674290768824 0.07212931987457112 98632168.44969736 29.869009592708693 236.00438060348637 0.02469178472021746 1.2007926144555853e-10 9.920531991909897 -0.160432092819635 IAVHCTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAVHCTVR 8 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 11788700.0 1621400.0 7381100.0 2786200.0 False True 2459782.3402178274 6063885.03620248 2235506.3487651604 1.0 2.4652120380966265 0.9088228304652329 21.230099230180887 -6.659740869318574 1.9734292012052195 1.9433048147864265 0.9152517920170433 0.23471564163989211 0.6238851813455298 0.48501595132985154 3.6306614572088947 0.25541889706843396 0.6917545537038713 2.1890673861656165e-07 6.659740869318574 -1.0280530227693832 IAVHCTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAVHCTVR 8 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 9976500.0 3659900.0 2349200.0 3967400.0 False True 5013063.935078585 2245404.5762344566 3030381.831167835 1.0 0.4479106201942461 0.6044969444660255 22.257261203251456 -10.677569926280967 10.177648828445527 1.0002477487816113 0.5262037823301949 0.9242834328107155 0.06392609919397406 0.0003595437398600398 1.1390454720635587e-05 0.06192645663750407 0.02063205979718873 2.1010194541221456e-11 10.677569926280967 -0.47404396645141633 IAVHCTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAVHCTVR 8 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 5253700.0 1621400.0 1776400.0 1855900.0 False True 2098934.2625722038 1677541.7784188997 1518145.243142103 1.0 0.7992350252852152 0.7232933733149152 21.001225552273336 -13.999999999999998 0.1348280117892772 1.9555637988315449 0.6231868459789269 0.9996243321569286 0.002262538019951718 11.932233607384706 0.11463700289378115 3.0098013629956055 0.08921911726282743 1.0000000000000041e-14 13.999999999999998 -1.332376952852618 IAVMELFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAVMELFR 8 0 Q16531;F5GY55;Q16531-2;F5H2L3;F5GYG8;F5GWI0;F5H198;F5GZY8 Q16531;F5GZY8 DDB1 DNA damage-binding protein 1 0 2781440.0 503940.0 1253800.0 1023700.0 False True 660670.2201619018 1066737.9272741217 917777.3440237934 1.0 1.614629954128567 1.3891610610190448 19.333570790859255 -10.082106441304928 4.507844540864795 0.9999660673519689 1.5018955075982914 0.8685389190935795 0.09204729026143356 14209649.155175108 15890434.22601445 4163.297216366381 0.031510234946967676 8.277392680981731e-11 10.082106441304928 0.5019294402463225 IAVMELFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAVMELFR 8 0 Q16531;F5GY55;Q16531-2;F5H2L3;F5GYG8;F5GWI0;F5H198;F5GZY8 Q16531;F5GZY8 DDB1 DNA damage-binding protein 1 0 3522340.0 503940.0 1475600.0 1542800.0 False True 690260.2364664346 1410403.112843336 1178422.4149633856 1.0 2.043291846077418 1.707214689051104 19.396780852382147 -10.16873115954435 4.616207980186399 0.9998727018381449 1.8752532675744518 0.9004313993875301 0.13720292485476612 0.00017977811911074404 3.237390787005265e-05 0.13286523308714493 0.04428205357954107 6.780611165566266e-11 10.16873115954435 0.8753805657363068 IAVMELFRPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAVMELFRPK 10 1 Q16531;F5GY55;Q16531-2;F5H2L3;F5GYG8;F5GWI0;F5H198;F5GZY8 Q16531;F5GZY8 DDB1 DNA damage-binding protein 1 0 8032900.0 2018700.0 2313900.0 3700300.0 False True 2646535.2491186075 1968675.1395115547 3317428.451783961 1.0 0.7438688527451864 1.2534986839448994 21.33567343863418 -6.770111316016359 1.574504100674478 0.8531073670934018 1.256344452955103 0.7308086066553818 0.10794728712687836 0.2662535200979351 1.3027414698586404 0.05404516516227977 0.1286117995399894 1.6978084235996045e-07 6.770111316016359 0.40323708586170126 IAVMELFRPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAVMELFRPK 10 1 Q16531;F5GY55;Q16531-2;F5H2L3;F5GYG8;F5GWI0;F5H198;F5GZY8 Q16531;F5GZY8 DDB1 DNA damage-binding protein 1 0 8822200.0 3493500.0 1075200.0 4253500.0 False True 3382600.7547452147 1504532.9670939262 3139380.7477352098 1.0 0.4447858544888343 0.928096744296882 21.689701476536012 -10.284928744198794 8.204368885352656 1.0000004261971038 0.6864412993928599 0.3594700586782915 0.19731084452670397 1.5381439849533837e-06 1.3393682907517947e-07 0.19104566276594326 0.06368180123983708 5.188851667554082e-11 10.284928744198794 -0.3135591268042439 IAVMELFRPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAVMELFRPK 10 1 Q16531;F5GY55;Q16531-2;F5H2L3;F5GYG8;F5GWI0;F5H198;F5GZY8 Q16531;F5GZY8 DDB1 DNA damage-binding protein 1 0 9904700.0 2018700.0 3664800.0 4221200.0 False True 2765067.943316251 3502877.018127032 3224239.4983429057 1.0 1.2668321682995964 1.1660615812846729 21.398883500157073 -10.105569566956149 4.286121252196965 0.9999696291912638 1.2164468747470938 0.8601671900522148 0.04113941996904751 21659165.695566207 0.6071417883969626 6786.310617646919 0.015055486091348429 7.842064916163074e-11 10.105569566956149 0.21647724555583003 IAVMELFRPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAVMELFRPK 10 1 Q16531;F5GY55;Q16531-2;F5H2L3;F5GYG8;F5GWI0;F5H198;F5GZY8 Q16531;F5GZY8 DDB1 DNA damage-binding protein 1 0 7089300.0 3493500.0 1777900.0 1817900.0 False True 2905000.0382911004 1768322.0998144813 2198014.4849800887 1.0 0.608716721688829 0.7566314822746425 21.470106751970288 -10.200479330873984 4.857533594940557 1.000041476913651 0.6826741019809678 0.859876953553738 0.06038594814618205 2.712792043854065e-05 4.46516970728865e-06 0.058476071531120576 0.019489480959214635 6.302613409404413e-11 10.200479330873984 -0.3173673749326832 IAVSNLHK(ub)ETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAVSNLHKETK 11 1 P23921 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 8491210.0 493410.0 1925800.0 6072000.0 True False 748539.0431027992 1582125.9436559235 4871866.538547852 1.0 2.1136184655082113 6.50850023581039 19.5137180423194 -6.945184171451245 0.6094277488634555 0.9513472563612012 7.899418410516306 0.9987670956789092 0.08350198609783328 0.08547912804464348 0.04442352058281409 0.0849238875216332 0.3705133215458934 1.1345295931816896e-07 6.945184171451245 6.948071154155105 IAVSNLHK(ub)ETK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAVSNLHKETK 11 1 P23921 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 7357510.0 493410.0 2036200.0 4827900.0 True False 638728.9715651604 1922883.6800363488 3949271.7384372842 1.0 3.01048451790821 6.18301645024786 19.28484436441185 -6.9644011073353544 0.36818583687198636 0.7509567265010003 8.552661359325084 0.9999002631635462 0.021308017146331997 0.07816477498131069 0.015580096819767391 0.04193527310179567 0.2697064044282203 1.085422681764312e-07 6.9644011073353544 7.801704632824084 IAVVGAGIGGSAVAHFLQQHFGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAVVGAGIGGSAVAHFLQQHFGPR 24 0 Q8NBM8;D6R9J0 Q8NBM8 PCYOX1L Prenylcysteine oxidase-like 0 56732600.0 24566000.0 18815600.0 13351000.0 False True 23786165.77674852 26328767.20205778 9853972.57858536 1.0 1.106894126996908 0.4142732658585028 24.503619398745396 -6.867509936590883 1.1472614456153143 1.059628246935145 0.3755969801123326 0.9621301826506735 0.059247108786319246 0.139260744332018 0.34414901660059083 0.04013776955503132 0.09463310940777245 1.3567194884117282e-07 6.867509936590883 -0.6840312668228123 down IAVVGAGIGGSAVAHFLQQHFGPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAVVGAGIGGSAVAHFLQQHFGPR 24 0 Q8NBM8;D6R9J0 Q8NBM8 PCYOX1L Prenylcysteine oxidase-like 0 211999000.0 52208000.0 70480000.0 89311000.0 False True 79203352.91605547 57902293.33724651 71658641.70359807 1.0 0.7310586131197612 0.9047425274981257 26.239058169427746 -10.732685184594887 5.734446258262402 1.0053383389168644 0.8179005703089477 0.594431005570168 0.07090616112603927 0.004956719342381927 0.00023106027150944207 0.07032027743871763 0.022884865098720817 1.8506096199165864e-11 10.732685184594887 -0.18743776860791672 IAVVGAGIGGSAVAHFLQQHFGPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAVVGAGIGGSAVAHFLQQHFGPR 24 0 Q8NBM8;D6R9J0 Q8NBM8 PCYOX1L Prenylcysteine oxidase-like 0 59877000.0 24566000.0 13444000.0 21867000.0 False True 20427717.458325226 13371574.50357492 26439288.598415524 1.0 0.6545799613125839 1.2942850150710454 24.284024674179673 -6.760078971367487 1.6124601024927432 0.7993772971121829 1.2966077074746647 0.6911783465344326 0.14528475153427686 0.2827857288573335 1.4491753237726963 0.07109417536387885 0.17081759282533054 1.7374848587407422e-07 6.760078971367487 0.49723041036248183 IAVVGAGIGGSAVAHFLQQHFGPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAVVGAGIGGSAVAHFLQQHFGPR 24 0 Q8NBM8;D6R9J0 Q8NBM8 PCYOX1L Prenylcysteine oxidase-like 0 152296000.0 52208000.0 55425000.0 44663000.0 False True 67584285.17353497 52340550.02750935 36534792.281079605 1.0 0.7744485259127243 0.5405811748584729 26.010184491520196 -6.970670485436942 0.2416363281555352 1.0822894118495756 0.22596229332595175 0.9999871491135993 0.00067236857596343 0.07608573112829824 0.00824783427395238 0.005526155082800484 0.022733795711188266 1.0698663167136354e-07 6.970670485436942 -0.8563271185236239 IAVYSCPFDGMITETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAVYSCPFDGMITETK 16 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 28423700.0 5706700.0 11162000.0 11555000.0 False True 7481538.963761408 9496673.10913523 10359399.443386657 1.0 1.2693475440192983 1.3846615640932758 22.834903634492715 -12.977868905725215 0.1262363802591447 1.7935636440289272e-17 1.563315131979281 0.999688302868158 0.002845612378574563 8.319984833905597 0.10045336755326002 2.224899400945671 0.14861424984119984 1.0522794624656693e-13 12.977868905725215 1.563315131979281 IAVYSCPFDGMITETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAVYSCPFDGMITETK 16 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 16235600.0 8448200.0 2424500.0 5362900.0 False True 8180016.515310871 3392615.4936004723 3958195.6064486164 1.0 0.41474433300353064 0.48388601649396423 22.9636723252703 -10.387825295427087 5.8939362778147695 1.0001357639326158 0.44931517474993626 0.9883149565819248 0.02822697408476492 5.036876557175009e-05 5.231541723854081e-06 0.027337294445353676 0.009110216712009957 4.094253270118841e-11 10.387825295427087 -0.5508205891826796 IAVYSCPFDGMITETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAVYSCPFDGMITETK 16 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 29447700.0 5706700.0 11493000.0 12248000.0 False True 7816621.207768785 10985201.257731404 9355274.655478055 1.0 1.4053644107524912 1.1968438033277131 22.898113696015606 -10.108704382598216 4.1970429742532485 0.9999494689240229 1.3011041070087996 0.7354628758022432 0.08512818171504576 29653819.63921937 1.7656174795364303 15672.757725563268 0.02914164084707768 7.785663285298203e-11 10.108704382598216 0.3011546380847767 IAVYSCPFDGMITETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAVYSCPFDGMITETK 16 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 11150800.0 8448200.0 0.0 2702600.0 False True 7025052.618717871 0.0 3267701.1645894637 1.0 0.0 0.46514970662039623 22.744077600704575 -10.160179194384408 5.204410324645016 1.0000326786385145 0.23257485330968716 0.7839855620200156 0.18989657253933695 7.200670673992342e-05 1.1619058149362873e-05 0.18387436732019385 0.061288855245302 6.915455732048946e-11 10.160179194384408 -0.7674578253288273 IAVYSCPFDGMITETK(ub)GTVLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAVYSCPFDGMITETKGTVLIK 22 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 18112900.0 7924200.0 6185300.0 4003400.0 True False 7672650.608487788 8655122.545913395 2954789.4405743866 1.0 1.1280485698565184 0.38510673707801607 22.87129362933635 -6.8624828724252875 1.1732004643850846 1.0699804853168293 0.3473987866246076 0.9565828888363407 0.0675707390750515 0.14426235868944315 0.37591759420094584 0.044875773060869165 0.10505852628626834 1.3725150887760804e-07 6.8624828724252875 -0.7225816986922218 down IAVYSCPFDGMITETK(ub)GTVLIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAVYSCPFDGMITETKGTVLIK 22 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 80449000.0 25985000.0 28537000.0 25927000.0 True False 39421144.75796249 23444349.389401358 20802517.085792203 1.0 0.5947150833225345 0.5276994672152538 25.23246633589115 -13.999999999999998 0.25324014796136834 3.865243265020994 0.5015720340014856 0.9995488726838169 0.0044316793485375235 14.128876631169977 0.15923735322843643 20.63314748507993 0.030380172861634427 1.0000000000000041e-14 13.999999999999998 -3.3636712310195085 IAVYSCPFDGMITETK(ub)GTVLIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAVYSCPFDGMITETKGTVLIK 22 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 21218700.0 7924200.0 7179400.0 6115100.0 True False 6589323.401581905 7140723.147200681 7393739.136972189 1.0 1.0836807835970537 1.1220786545697798 22.651698904770626 -13.999999999999638 0.10464252396994415 0.591776779463099 1.1982795966842685 0.9997702780639716 0.0007724862127947215 12.046609223061882 0.09724116328861779 1.050344259363048 0.06780306786263325 1.0000000000008345e-14 13.999999999999638 0.6065028172211695 IAVYSCPFDGMITETK(ub)GTVLIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAVYSCPFDGMITETKGTVLIK 22 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 60686000.0 25985000.0 20670000.0 14031000.0 True False 33638094.74092687 19519696.329609696 11477501.970217599 1.0 0.5802854317388086 0.34120547131503043 25.0035926579836 -9.211202179656333 0.16367578465057359 1.509039830258177 8.558493141979244e-10 0.9997598629822133 0.0042196666887331525 0.6503627935236065 0.05795614856256408 0.3292756887395552 0.16683344472094033 6.148905524650122e-10 9.211202179656333 -1.5090398294023275 IAWALSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAWALSR 7 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 25292100.0 5994000.0 6170100.0 13128000.0 False True 7858192.045978574 5249545.13086143 11769640.492668131 1.0 0.6680347209824024 1.4977542447172998 22.905765995506535 -6.798129124263408 1.4635838594610315 0.8164035744133876 1.5086801328004429 0.8266253451037024 0.14197743313677097 0.22343858169634834 0.9451092679802002 0.07632270784726575 0.17770107630052684 1.591735402550665e-07 6.798129124263408 0.6922765583870553 IAWALSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IAWALSR 7 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 11332100.0 4878000.0 1261500.0 5192600.0 False True 4723150.5600822 1765223.528635595 3832502.285339103 1.0 0.3737385683942444 0.8114292010357602 22.171318094400174 -9.823365261795526 5.789189047690912 1.0000000628459442 0.5925838847137883 0.5360193730005332 0.17868645253257098 1.4513172626277441e-07 2.939163351526491e-08 0.1730124420696788 0.05767080457028598 1.5018782854842125e-10 9.823365261795526 -0.4074161781321559 IAWALSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAWALSR 7 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 17419200.0 5994000.0 5203800.0 6221400.0 False True 8210143.781759361 4973878.909334603 4752033.4537549885 1.0 0.605821169707791 0.5788002719651116 22.968976057029426 -13.999999999999998 0.3806866074346692 6.8738191377784625 0.576454798319428 0.9998086233495005 0.002663058611957508 24.121364943369343 0.20127711844163876 116.14872975085136 0.007308576952291823 1.0000000000000041e-14 13.999999999999998 -6.297364339459034 IAWALSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAWALSR 7 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 11393000.0 4878000.0 4737100.0 1777900.0 False True 4056273.1320406455 4711580.302059269 2149650.669919192 1.0 1.1615540050403235 0.5299570812771519 21.95172336983445 -6.838862094024204 1.2877412512400535 1.0859580479108808 0.509656176502982 0.9224685524969732 0.07459654734590539 0.17013214169021407 0.5485362698091029 0.04543263620106546 0.1046340948173975 1.449231969961658e-07 6.838862094024204 -0.5763018714078988 IAWALSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAWALSR 7 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 12823900.0 4149200.0 4681500.0 3993200.0 False True 5371221.192959536 4420970.409630763 3266478.573692034 1.0 0.8230847791980085 0.608144490115889 22.356818703853364 -6.968522937556284 0.2913132864462399 1.0413436276661845 0.3832326752448323 0.9999684587052005 0.0008998324933909977 0.07678496410760281 0.010736798618047827 0.0037288346495672133 0.019462324939735896 1.0751698130735091e-07 6.968522937556284 -0.6581109524213522 IAWECPEK(ub)NCAQGEGSMAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAWECPEKNCAQGEGSMAK 19 1 Q9C0C9 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 20289500.0 8223500.0 12066000.0 0.0 True False 10781088.13648728 10265799.832899623 0.0 1.0 0.952204425280253 0.0 23.361999461030045 -7.063575142266443 1.0336477971797149 1.0086634062198419 2.769450770809149e-20 0.9884855212552839 0.04941983708279131 0.08461017670891134 0.17341468476714925 0.0398493402388655 0.07105591720530015 8.63823187802404e-08 7.063575142266443 -1.0086634062198419 down IAWECPEK(ub)NCAQGEGSMAK ddPTM_RPMI8226_Bortezomib_8h_R1 2 IAWECPEKNCAQGEGSMAK 19 1 Q9C0C9 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 64904900.0 26588900.0 25641900.0 12674100.0 True False 40337305.20896623 21065902.60392087 10169058.579744628 1.0 0.5222436772806109 0.2521005934100981 25.265611370088006 -8.878927691173667 0.21518582177269135 1.3488878325588936 4.915932279787404e-11 0.999507155160439 0.006864830292600561 0.3774328867292074 0.06733687971015975 0.2228539327156684 0.12869177153043254 1.3215156445589237e-09 8.878927691173667 -1.3488878325097342 down IAWECPEK(ub)NCAQGEGSMAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAWECPEKNCAQGEGSMAK 19 1 Q9C0C9 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 23508500.0 8223500.0 9820000.0 5465000.0 True False 11263950.181731405 9386119.929602558 4174279.5552079934 1.0 0.8332884803437401 0.3705875370416772 23.425209522552937 -6.953185716057762 0.5227058452176572 1.0077012974887187 0.17543045356981826 0.9994281301914469 0.006367262966333707 0.08223126641236533 0.030859799589762024 0.007182617491799718 0.03822992072409465 1.1138181330022382e-07 6.953185716057762 -0.8322708439189005 down IAWECPEK(ub)NCAQGEGSMAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAWECPEKNCAQGEGSMAK 19 1 Q9C0C9 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 39237000.0 18267000.0 15153000.0 5817000.0 True False 23646991.596402176 14309722.229442466 4758365.687460327 1.0 0.605139227588665 0.201224991689188 24.495153317754067 -7.61257370557398 0.3650691970456016 1.056458460779676 7.959810142087526e-19 0.9990396523893087 0.010105837273174696 0.1226937712985598 0.049502955652551 0.02521800539692895 0.0722163972294491 2.4402048975355558e-08 7.61257370557398 -1.056458460779676 down IAWQK(ub)GGIFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IAWQKGGIFK 10 1 Q05932-3;Q05932-2;Q05932-4;Q05932;Q5JU21;Q5JU20;Q5JU23 Q05932-3 FPGS Folylpolyglutamate synthase, mitochondrial 1 24519300.0 2158100.0 5590200.0 16771000.0 True False 3273995.4782435573 4592585.133568043 13456204.499009557 1.0 1.4027463275642293 4.110025376769482 21.642620898613302 -6.933480287964809 0.7176468052876604 0.9636706487615967 4.71851528285287 0.9971791879109521 0.07334539077809413 0.09087048664585629 0.06911888085384002 0.06826267323566945 0.24044642263061597 1.1655199510002402e-07 6.933480287964809 3.754844634091273 up IAWQK(ub)GGIFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IAWQKGGIFK 10 1 Q05932-3;Q05932-2;Q05932-4;Q05932;Q5JU21;Q5JU20;Q5JU23 Q05932-3 FPGS Folylpolyglutamate synthase, mitochondrial 1 20321400.0 2158100.0 3687300.0 14476000.0 True False 2793702.992510843 3482098.5136027983 11841516.536303187 1.0 1.2464097017246845 4.2386454709205195 21.41374722070575 -6.923223314955187 0.8004585970616216 0.9413283981244845 4.758853052629941 0.9950303914965412 0.10377452023676247 0.09631233468511534 0.09605782549448896 0.09097375710056292 0.28150475777167894 1.1933743115870608e-07 6.923223314955187 3.817524654505456 up IAWTHITIPESLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IAWTHITIPESLR 13 0 E7EN89;Q9H0E2;E9PP67;E9PQ25;Q9H0E2-2;F2Z2Y8 E7EN89 TOLLIP Toll-interacting protein 0 3451700.0 955430.0 1547700.0 948570.0 False True 1252577.982397281 1316789.1928873477 850421.0757259452 1.0 1.0512632437999383 0.6789366312334049 20.25646899415434 -6.872108513216832 1.1229581616525224 1.0293937013307777 0.6562467857409595 0.9667388398567732 0.030049814681833143 0.13484530766239897 0.3165394411729214 0.020740750538967526 0.04928962806110794 1.3424294985666516e-07 6.872108513216832 -0.37314691558981816 IAWTHITIPESLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IAWTHITIPESLR 13 0 E7EN89;Q9H0E2;E9PP67;E9PQ25;Q9H0E2-2;F2Z2Y8 E7EN89 TOLLIP Toll-interacting protein 0 3043130.0 955430.0 1044300.0 1043400.0 False True 1308678.2905249149 998159.3729617062 796970.4094975335 1.0 0.762723260704005 0.6089887906506543 20.31967905567723 -8.884281642831393 0.08294159763825651 1.6674751554127254 1.4263190303115156e-07 0.9999847099924161 0.0006288954497519474 0.3856352999183629 0.024974895846288953 0.2721211730396023 0.21607814035946127 1.3053241023123704e-09 8.884281642831393 -1.6674750127808224 IAWTHITIPESLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IAWTHITIPESLR 13 0 E7EN89;Q9H0E2;E9PP67;E9PQ25;Q9H0E2-2;F2Z2Y8 E7EN89 TOLLIP Toll-interacting protein 0 4510240.0 2805200.0 571040.0 1134000.0 False True 2332648.091431 567963.6941774347 1371114.156976411 1.0 0.24348451713048938 0.5877929731506475 21.15353724482393 -10.602957686355753 6.51876953368885 1.001508183118279 0.4156387451460479 0.7934167216898222 0.1405633385624817 0.003087378525650955 0.00018804433352651663 0.13638102884944606 0.04536662244498385 2.4948377890599153e-11 10.602957686355753 -0.5858694379722311 ICANK(ub)YMVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICANKYMVK 9 1 F8W7C6;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 2871770.0 518560.0 856210.0 1497000.0 True False 679837.1817421834 728466.8054804394 1342104.8002379783 1.0 1.0715312799068086 1.9741562189914887 19.374829742536075 -6.922681045859142 0.8045892705931137 0.9819426832814273 2.129085558464281 0.9948939256741501 0.031678543819962705 0.0966197557624047 0.09762633214387191 0.027689267804014546 0.08519358160511559 1.1948653141540953e-07 6.922681045859142 1.1471428751828536 ICANK(ub)YMVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ICANKYMVK 9 1 F8W7C6;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 32665300.0 2204100.0 7020200.0 23441000.0 True False 3343780.8412940195 5767390.460927047 18807876.075444706 1.0 1.7248111448282322 5.624733488264797 21.673048862454813 -6.938182674128363 0.6762576949074782 0.9545435894929137 6.622483151968589 0.9979160683384958 0.09271317625390453 0.08860554637677324 0.058458757362390985 0.0890520425722472 0.33843408184111845 1.1529681911909819e-07 6.938182674128363 5.667939562475675 ICANK(ub)YMVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICANKYMVK 9 1 F8W7C6;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 7129790.0 518560.0 641630.0 5969600.0 True False 710285.6455570791 613280.6650133298 4559703.4277712125 1.0 0.86342821208548 6.41953481151238 19.438039804058967 -6.901267191487538 0.9532419244458795 0.7769607562922262 7.0179442726637715 0.9871857219317162 0.29291497143828366 0.11047787352495515 0.17221434433645072 0.22990766131154128 0.6020611950007502 1.2552574526140377e-07 6.901267191487538 6.2409835163715455 up ICANK(ub)YMVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICANKYMVK 9 1 F8W7C6;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 28640500.0 2204100.0 7394400.0 19042000.0 True False 2853250.8993064035 6982895.139799993 15576551.387419531 1.0 2.447347038950365 5.459229467414182 21.444175184547262 -6.959261194318549 0.44572363654226316 0.8985137865286061 7.12661473578391 0.9997418100193162 0.029845995010290016 0.07996609156549282 0.022114447336701662 0.04001001462639372 0.24929979819542392 1.0983450717040972e-07 6.959261194318549 6.228100949255304 ICDDELILIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICDDELILIK 10 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 25520900.0 6358700.0 9444500.0 9717700.0 False True 8336317.277738402 8035417.414372662 8712205.622760598 1.0 0.9639049410740071 1.0450904557130978 22.990978756526612 -6.785844322971762 1.5128415067416685 0.9797165298002175 1.045858238365093 0.7875724483514052 0.015307177848555193 0.24161693434400425 1.0924594382499582 0.007966078729873245 0.018708979410507823 1.6374033592033222e-07 6.785844322971762 0.06614170856487545 ICDDELILIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICDDELILIK 10 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 27358200.0 6358700.0 11268000.0 9731500.0 False True 8709683.227406284 10770142.501706906 7433120.1265336955 1.0 1.2365710922547777 0.8534317417129825 23.054188818049504 -6.7396852912042355 1.6880138349417149 1.140810645196923 0.8532294895967112 0.6034728646362348 0.0993975129917103 0.3183785258636773 1.781174190635001 0.0465873281902715 0.11435332858927716 1.8210199714075608e-07 6.7396852912042355 -0.2875811556002119 ICDFGFAK(ub)QLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICDFGFAKQLR 11 1 E9PGT3;Q15418;Q15418-4;Q15418-2;Q15418-3;Q9UK32-2;Q9UK32;B4DG22;B1AXG1;B7ZB17;P51812 E9PGT3;B4DG22 RPS6KA1;RPS6KA6;RPS6KA3 Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase alpha-6;Ribosomal protein S6 kinase alpha-3 1 5025700.0 1246300.0 1756600.0 2022800.0 True False 1633911.3691863671 1494522.127173172 1813500.060067722 1.0 0.9146898389705151 1.1099133614394177 20.63989829656341 -6.78797005553459 1.504824384120267 0.9521935358746721 1.1118638755208847 0.7945534172894952 0.036220342887909845 0.23839543726885898 1.0665741750500481 0.01894930660028918 0.04442402829871434 1.6294083759522355e-07 6.78797005553459 0.15967033964621258 ICDFGFAK(ub)QLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICDFGFAKQLR 11 1 E9PGT3;Q15418;Q15418-4;Q15418-2;Q15418-3;Q9UK32-2;Q9UK32;B4DG22;B1AXG1;B7ZB17;P51812 E9PGT3;B4DG22 RPS6KA1;RPS6KA6;RPS6KA3 Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase alpha-6;Ribosomal protein S6 kinase alpha-3 1 5640800.0 1246300.0 1574200.0 2820300.0 True False 1707090.7899911043 1504646.6388167387 2154203.2259017583 1.0 0.8814098509807903 1.2619148545186538 20.7031083580863 -6.82296694525177 1.3589748354742985 0.9362654114182916 1.2707633499611248 0.8910760169806238 0.05246632863141785 0.1896525960837089 0.6874007883065875 0.03033205952789615 0.06986183915757735 1.503256376639074e-07 6.82296694525177 0.3344979385428333 ICDFGFAK(ub)QLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICDFGFAKQLR 11 1 E9PGT3;Q15418;Q15418-4;Q15418-2;Q15418-3;Q9UK32-2;Q9UK32;B4DG22;B1AXG1;B7ZB17;P51812 E9PGT3;B4DG22 RPS6KA1;RPS6KA6;RPS6KA3 Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase alpha-6;Ribosomal protein S6 kinase alpha-3 1 16551600.0 2746600.0 0.0 13805000.0 True False 3555527.843580128 0.0 11292631.65126176 1.0 0.0 3.176077406242724 21.761632323482864 -6.822064832975986 1.3628930594195676 0.46208005851590694 3.2485518814377405 0.8890661664582322 0.44162348285448144 0.19081445189236212 0.6958687931691707 0.25459464405707355 0.5865083060015825 1.5063821714820323e-07 6.822064832975986 2.7864718229218335 ICDQISDAVLDAHLQQDPDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICDQISDAVLDAHLQQDPDAK 21 0 P31153 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 18792900.0 2254000.0 9355000.0 7183900.0 False True 2955015.8277670504 7959270.465504386 6440578.940834742 1.0 2.693478116331711 2.1795412668572904 21.49473442716518 -9.95714395269587 6.6110621877817 0.9999998173257032 2.4365096915945195 0.9124101529330287 0.2098138402043834 5.663932530243256e-07 8.97480105457808e-08 0.2031514044719283 0.06771712574294014 1.1037127189690882e-10 9.95714395269587 1.4365098742688163 ICDQISDAVLDAHLQQDPDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ICDQISDAVLDAHLQQDPDAK 21 0 P31153 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 8846800.0 4862300.0 1328100.0 2656400.0 False True 4707948.947988456 1858417.255950005 1960609.1497081988 1.0 0.394740316108152 0.4164465612028141 22.166667245502737 -10.205010470907453 5.048322094822263 1.000057639324986 0.405593438655054 0.9990008526924622 0.008861537454077858 5.749368918128643e-06 9.05379499191589e-07 0.008580974908929864 0.0028600489148628955 6.237197973198869e-11 10.205010470907453 -0.5944642006699321 ICDQISDAVLDAHLQQDPDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICDQISDAVLDAHLQQDPDAK 21 0 P31153 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 21603800.0 2254000.0 10591000.0 8758800.0 False True 3087364.7120596585 10123054.600246504 6690151.833148366 1.0 3.27886581093076 2.1669457472956597 21.557944488688072 -10.519513072517022 10.853250867280488 0.9999894945100561 2.72290577911321 0.7619735423975003 0.45393946511149946 0.00011539317730351707 5.107692807286922e-06 0.43952764552147516 0.14650833238026167 3.0233395648587107e-11 10.519513072517022 1.7229162846031536 ICDQSGVHYK(ub)VLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICDQSGVHYKVLNR 14 1 Q9Y2Z2-2;Q9Y2Z2-4;Q9Y2Z2-6;Q9Y2Z2;Q9Y2Z2-5;Q9Y2Z2-3;E7EWI1;E7EWX0;E9PHR8 Q9Y2Z2-2 MTO1 Protein MTO1 homolog, mitochondrial 1 5467900.0 1302900.0 1665400.0 2499600.0 True False 1708114.5173015473 1416928.8116783558 2240965.369856278 1.0 0.8295279955332256 1.3119526513927884 20.703973270280645 -6.8112089347858875 1.4095289025708329 0.9072254544139775 1.3206205971885365 0.8629306408243008 0.0739540401122252 0.20516393217005569 0.8031536499062213 0.04125314672939446 0.09537207032477377 1.5445112116835487e-07 6.8112089347858875 0.413395142774559 ICDQSGVHYK(ub)VLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICDQSGVHYKVLNR 14 1 Q9Y2Z2-2;Q9Y2Z2-4;Q9Y2Z2-6;Q9Y2Z2;Q9Y2Z2-5;Q9Y2Z2-3;E7EWI1;E7EWX0;E9PHR8 Q9Y2Z2-2 MTO1 Protein MTO1 homolog, mitochondrial 1 5137700.0 1302900.0 1552300.0 2282500.0 True False 1784617.3395485922 1483714.2532303527 1743420.5095630833 1.0 0.8313906966776692 0.9769155946921767 20.767183331803537 -10.182698420921287 5.959831377757835 1.0000012900254094 0.9041531456942412 0.3664425279212332 0.05941029083435456 1.0183426146770991e-06 1.3965753613119344e-07 0.05752454076566225 0.019174588916232308 6.566010593512426e-11 10.182698420921287 -0.09584814433116817 ICDQWDALGSLTHSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICDQWDALGSLTHSR 15 0 O43707;O43707-2;O43707-3;F5GXS2 O43707 ACTN4 Alpha-actinin-4 0 12895000.0 2082400.0 4214200.0 6598400.0 False True 2730046.5659902873 3585457.786822944 5915660.86432217 1.0 1.3133320989791863 2.166871780876142 21.38049412850971 -6.953597274275257 0.5178482943102183 0.9852511879341664 2.5329035253240293 0.9994541846192089 0.01152005845747201 0.08207261725637825 0.03022713365325359 0.013095910711420881 0.07048842202086283 1.112763125647178e-07 6.953597274275257 1.547652337389863 up ICDVYNAVMDVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICDVYNAVMDVVK 13 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 7283490.0 767990.0 4703800.0 1811700.0 False True 1006842.3272257393 4002011.3752687913 1624242.6630535396 1.0 3.9748143945199077 1.613204589370999 19.941406342500137 -6.588403916939321 2.2341159606805485 3.015372776467637 1.6197920933037318 0.0 1.2895981634549767 0.6743738834082208 6.342850628472671 0.48221691164209474 1.4386307540119985 2.5798596679589945e-07 6.588403916939321 -1.3955806831639053 ICDVYNAVMDVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICDVYNAVMDVVK 13 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 9565190.0 767990.0 2319200.0 6478000.0 False True 1051936.6571493773 2216730.0754311876 4948029.818597883 1.0 2.1072847498615186 4.70373361834015 20.00461640402303 -6.956819231158366 0.4781570593889513 0.9365840971945387 5.982350674409219 0.9996334373904765 0.029719070716238416 0.08085752512195146 0.025482732437098695 0.03647343308198845 0.21420027189283397 1.1045382724283115e-07 6.956819231158366 5.045766577214681 ICEMAAYFTHSNLQPVHMILVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ICEMAAYFTHSNLQPVHMILVLR 23 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 67700000.0 18680000.0 17898000.0 31122000.0 False True 28338925.69092703 14703962.062287735 24970723.058742847 1.0 0.5188609555158735 0.8811457191807894 24.75628173193291 -9.901643988979469 6.030503374529633 1.0000000713636068 0.7000033373482143 0.4776059135878844 0.1479021354277236 1.418074307606152e-07 2.5831504197862453e-08 0.1432056609875816 0.04773520894827952 1.254168853151822e-10 9.901643988979469 -0.2999967340153925 ICEMAAYFTHSNLQPVHMILVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICEMAAYFTHSNLQPVHMILVLR 23 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 53450000.0 18680000.0 12329000.0 22441000.0 False True 24181628.237849277 11642880.311937986 18356968.264104713 1.0 0.48147627601496484 0.7591287105874963 24.527408054025358 -10.060976944321911 5.224421529068587 1.0000047161268408 0.620302493300475 0.713755000040438 0.11335113176001378 6.226778035594902e-06 1.1188161963054698e-06 0.10975312498824544 0.03658392046464327 8.690065615872294e-11 10.060976944321911 -0.3797022228263658 ICEQFEAETPTDSETTQK(ub)AR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICEQFEAETPTDSETTQKAR 20 1 Q5QNY5;P40855;P40855-5;H0YJ60;H0YDY4 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 25136700.0 5227800.0 8436900.0 11472000.0 True False 6853696.426087211 7178147.406778623 10284987.487194443 1.0 1.0473395610953027 1.500648241151551 22.70845086064466 -6.926911587228002 0.7717080694689169 0.9922605518189948 1.586794750787878 0.9958960571192338 0.0144574421343619 0.09427277457745672 0.08576650401691167 0.012937212387856604 0.041734541656364796 1.1832824213938044e-07 6.926911587228002 0.5945341989688832 ICEQFEAETPTDSETTQK(ub)AR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ICEQFEAETPTDSETTQKAR 20 1 Q5QNY5;P40855;P40855-5;H0YJ60;H0YDY4 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 19805500.0 6896900.0 6876800.0 6031800.0 True False 6677961.684672187 9622742.102038244 4451890.629878753 1.0 1.440969948079391 0.6666541139487372 22.67097638517324 -6.752227741926367 1.6416184575606667 1.258597352262901 0.664850764359226 0.6585064472592304 0.18532228018651817 0.29616901776065147 1.5710188269367693 0.08915370346673841 0.21593573063855342 1.7691809650775327e-07 6.752227741926367 -0.5937465879036751 ICEQFEAETPTDSETTQK(ub)AR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ICEQFEAETPTDSETTQKAR 20 1 Q5QNY5;P40855;P40855-5;H0YJ60;H0YDY4 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 109252000.0 20235000.0 64477000.0 24540000.0 True False 30697974.37665465 52970575.58889964 19689658.243735902 1.0 1.725539768160826 0.6413992663538606 24.87164012589267 -6.726357106158278 1.7365476226953183 1.4383859676861341 0.6424643693547661 0.5423018601312551 0.30509630024503137 0.3431002539939692 2.0252467538144714 0.13932793426048762 0.34716326451391805 1.8777721511582182e-07 6.726357106158278 -0.795921598331368 ICEQFEAETPTDSETTQK(ub)AR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICEQFEAETPTDSETTQKAR 20 1 Q5QNY5;P40855;P40855-5;H0YJ60;H0YDY4 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 22832800.0 5227800.0 6819000.0 10786000.0 True False 7160658.935982905 6517714.032582469 8238568.944642894 1.0 0.9102114890335602 1.1505322370883218 22.771660922167552 -6.805549556089747 1.4334340755942563 0.9508024827970688 1.1543109302688777 0.8478073174205465 0.03868016786102863 0.2129400228958701 0.8631734612120596 0.02122422307881173 0.04919613286384399 1.5647697576771236e-07 6.805549556089747 0.20350844747180885 ICEQFEAETPTDSETTQK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ICEQFEAETPTDSETTQKAR 20 1 Q5QNY5;P40855;P40855-5;H0YJ60;H0YDY4 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 19943000.0 6896900.0 5043400.0 8002700.0 True False 5735077.934475427 5016230.203163486 9676027.569695875 1.0 0.8746577222620268 1.6871658380664913 22.451381660607517 -6.867528544486628 1.14716464000295 0.9300744846801878 1.7325526461190393 0.9621496938407086 0.06948626257496332 0.1392425422855422 0.3440347501676109 0.04707792890262804 0.11099917911321525 1.3566613592965456e-07 6.867528544486628 0.8024781614388514 ICEQFEAETPTDSETTQK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICEQFEAETPTDSETTQKAR 20 1 Q5QNY5;P40855;P40855-5;H0YJ60;H0YDY4 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 101311000.0 20235000.0 64216000.0 16860000.0 True False 26194606.391481828 60642323.14959934 13791652.998208886 1.0 2.3150690735066553 0.5265073577396363 24.64276644798512 -6.709647460039262 1.7962409687738627 1.8087507381846808 0.5307109515553663 0.46353648483347554 0.5541918787831693 0.3757804787849586 2.3631962729044127 0.24553311979929288 0.6240878347287074 1.9514280350574703e-07 6.709647460039262 -1.2780397866293145 ICGDIHGQYTDLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICGDIHGQYTDLLR 14 0 P62140;E7ETD8;C9J9S3;C9JP48 P62140 PPP1CB Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase 0 30219900.0 7017900.0 12120000.0 11082000.0 False True 9200534.861440264 10311743.243389975 9935340.946050292 1.0 1.1207764981802113 1.079865583433592 23.13328630218054 -10.120123345892294 4.423672318299416 0.9999871439953636 1.1003210408119588 0.8891057433836931 0.016701811023745572 2.1179168776941967e-06 4.2129810797834413e-07 0.016173531102682704 0.005390486326475778 7.583621586567147e-11 10.120123345892294 0.10033389681659521 ICGDIHGQYTDLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICGDIHGQYTDLLR 14 0 P62140;E7ETD8;C9J9S3;C9JP48 P62140 PPP1CB Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase 0 21160200.0 7017900.0 8711600.0 5430700.0 False True 9612607.281616436 8326692.706591212 4148080.5087773274 1.0 0.8662262446230938 0.4315250157686453 23.19649636370343 -6.949642714736463 0.5627606823771607 1.0056052952248442 0.2712725166395931 0.9991728863071245 0.0069792559740175526 0.08362970008698635 0.03655980002494945 0.007456662055659804 0.03615746218904916 1.122941895928034e-07 6.949642714736463 -0.7343327785852511 down ICGDIHGQYYDLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICGDIHGQYYDLLR 14 0 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62136;P62136-2;E9PMD7;F5H1L6;F5H037 P36873;P62136 PPP1CC;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 0 32595900.0 8824100.0 14289000.0 9482800.0 False True 11568480.552705951 12157136.898085758 8501610.821440691 1.0 1.0508844997143654 0.7348943348875755 23.463696052163513 -6.865636244743424 1.1568550017345023 1.0281458954191873 0.7178548192603549 0.9601346860842076 0.027659713860386945 0.1411117275538494 0.3557004590452933 0.018599856847269468 0.04373417296312359 1.3625854754904866e-07 6.865636244743424 -0.31029107615883245 ICGDIHGQYYDLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ICGDIHGQYYDLLR 14 0 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62136;P62136-2;E9PMD7;F5H1L6;F5H037 P36873;P62136 PPP1CC;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 0 4451300.0 0.0 1968900.0 2482400.0 False True 0.0 2755092.037677862 1832184.9695963056 0.0 ICGDIHGQYYDLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICGDIHGQYYDLLR 14 0 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62136;P62136-2;E9PMD7;F5H1L6;F5H037 P36873;P62136 PPP1CC;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 0 28328800.0 8824100.0 8512700.0 10992000.0 False True 12086608.23233612 8136580.766265565 8395915.987346085 1.0 0.6731897493373881 0.6946461592826284 23.526906113686405 -10.47648403560611 6.08451501842178 1.0002062809295198 0.6839179543100085 0.9965558855732188 0.008759542679636289 2.452719685101966e-05 2.1103444407768785e-06 0.008486854640044054 0.0028271302432186897 3.338227760571921e-11 10.47648403560611 -0.31628832661951134 ICGLDPTSTLGIYFEVVNQHNTPIPQGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ICGLDPTSTLGIYFEVVNQHNTPIPQGGR 29 0 A0A2R8YFH5;Q15437 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 0 51631000.0 12771000.0 19885000.0 18975000.0 False True 19374540.685162157 16336366.387785856 15224582.932962062 1.0 0.8431872865144584 0.7858035542809896 24.207658772838748 -13.999999999999998 0.13977451364473542 1.7489193284096989 0.7145948933383388 0.9996038305031189 0.0018019262744345362 11.933733275525253 0.1171182158993819 2.437960645535926 0.0636498246232899 1.0000000000000041e-14 13.999999999999998 -1.03432443507136 ICGLDPTSTLGIYFEVVNQHNTPIPQGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICGLDPTSTLGIYFEVVNQHNTPIPQGGR 29 0 A0A2R8YFH5;Q15437 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 0 36815000.0 12771000.0 10793000.0 13251000.0 False True 16532311.25404567 10192360.062190508 10839453.96674174 1.0 0.6165115031751115 0.6556526670818145 23.978785094931197 -9.95650093862355 7.094857679130382 1.0000000143722596 0.6360820855098026 0.9913985788461588 0.015979313251679297 3.635438615165353e-09 5.199243919857574e-10 0.015471904218542637 0.0051573011756318315 1.1053480804350111e-10 9.95650093862355 -0.363917928862457 ICHGKPVTQVTWHGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICHGKPVTQVTWHGR 15 1 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 13403100.0 2766100.0 3922800.0 6714200.0 False True 3626383.886950506 3337533.5309546394 6019478.991154199 1.0 0.9203475514450385 1.65991223731586 21.790100225372754 -6.880235728299599 1.0784531696077098 0.9504740255670442 1.7125686394717792 0.9738763858120786 0.05357303121674118 0.12742287348162393 0.2710093153928998 0.03825743117752403 0.09257425953783853 1.3175414034269818e-07 6.880235728299599 0.762094613904735 ICHGKPVTQVTWHGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ICHGKPVTQVTWHGR 15 1 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 3440380.0 2089300.0 873720.0 477360.0 False True 2022976.3151249974 1222600.9523896072 352325.0955069661 1.0 0.6043575217607351 0.17416175012666738 20.94804799833963 -7.606099239981909 0.39966726939177816 1.042043797089395 2.66817446336636e-21 0.9985923003192402 0.012653218451140622 0.12099498545159024 0.056421279486805566 0.02398137960277352 0.0719656122090062 2.476856010303439e-08 7.606099239981909 -1.042043797089395 down ICHGKPVTQVTWHGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICHGKPVTQVTWHGR 15 1 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 13011400.0 2766100.0 3361000.0 6884300.0 False True 3788801.921041803 3212499.9066592865 5258370.126609044 1.0 0.8478933376849505 1.3878714792150326 21.853310286895645 -6.831500301185591 1.3213712931447497 0.9188081033149579 1.4028336530019927 0.9088087831729628 0.06865229866576153 0.17896871218574348 0.6106324994967567 0.04078873573088378 0.09385550411217614 1.4740075187412057e-07 6.831500301185591 0.4840255496870348 ICHGKPVTQVTWHGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ICHGKPVTQVTWHGR 15 1 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 4984870.0 2089300.0 983370.0 1912200.0 False True 1737345.521683583 978072.3906263377 2312032.178986148 1.0 0.5629694142121666 1.3307843201769456 20.728453273773905 -6.752274486434085 1.6411533780868715 0.7437353952107671 1.3326080412805492 0.6588521109793403 0.18366812940997468 0.29607267935173653 1.5695813096355495 0.08837741706935379 0.2140696937346444 1.7689905527046473e-07 6.752274486434085 0.5888726460697821 ICHGKPVTQVTWHGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICHGKPVTQVTWHGR 15 1 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 17112300.0 2150000.0 4791300.0 10171000.0 False True 2783217.382835968 4524659.943108807 8319982.363272979 1.0 1.6256940514284914 2.989339752827825 21.408322163905154 -6.958330393981599 0.4583574929723582 0.9595934954442817 3.7102604019436964 0.9997031779565122 0.014309351880518788 0.0803030093682831 0.023376345557712626 0.018468716786801898 0.11267165979909842 1.1007016208938814e-07 6.958330393981599 2.750666906499415 ICHQIEYYFGDFNLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICHQIEYYFGDFNLPR 16 0 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 0 28572600.0 10093000.0 12934000.0 5545600.0 False True 13232020.740751022 11004297.616337128 4971794.509151457 1.0 0.831641502982752 0.3757396248510768 23.657530065211475 -6.953728324070288 0.5162982587835128 1.0079745887070266 0.17918957178417486 0.9994622951546703 0.006115053618418758 0.08202237511154484 0.03002774041503402 0.006969120466164476 0.03764480548930357 1.112427396353172e-07 6.953728324070288 -0.8287850169228518 down ICHQIEYYFGDFNLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ICHQIEYYFGDFNLPR 16 0 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 0 93361900.0 45538300.0 24728600.0 23095000.0 False True 44092711.592905164 34602858.93794541 17045726.66485123 1.0 0.7847750271614791 0.38658830561906316 25.39403686607664 -6.961539453525963 0.413165319097121 1.0189507316448283 0.13755902761285094 0.9998231016653671 0.0033797415627636242 0.07915571401669547 0.01913271743644649 0.005132778702886875 0.033212360405545496 1.0925983654716694e-07 6.961539453525963 -0.8813917040319774 down ICHQIEYYFGDFNLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ICHQIEYYFGDFNLPR 16 0 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 0 212893700.0 47829900.0 98134800.0 66929000.0 False True 72561455.13407223 80621878.20930803 53700453.81397723 1.0 1.1110840881063164 0.7400685903384184 26.11270005190901 -6.82644194473688 1.3436251373024533 1.0595200255294355 0.7307845064782463 0.8985769937041796 0.049514571604867025 0.18525353661100752 0.6553056162532183 0.028943305531699087 0.06662845461045125 1.4912760917167232e-07 6.82644194473688 -0.32873551905118914 ICHQIEYYFGDFNLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICHQIEYYFGDFNLPR 16 0 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 0 49454000.0 10093000.0 14369000.0 24992000.0 False True 13824654.853069253 13734130.068071222 19089404.32639676 1.0 0.9934519316424067 1.380823212534573 23.720740126734366 -6.903056609471987 0.9417424013300647 0.9852169095637691 1.4241054989440824 0.9880264153871885 0.019815012018894896 0.10919066448659843 0.16500325349698342 0.01568528148307177 0.04147327885074776 1.2500960719166027e-07 6.903056609471987 0.4388885893803134 ICHQIEYYFGDFNLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ICHQIEYYFGDFNLPR 16 0 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 0 76297300.0 45538300.0 11295000.0 19464000.0 False True 37867114.13874675 11234151.59311803 23533832.408632167 1.0 0.29667303275226126 0.6214847089324838 25.174442141510916 -10.552846038676059 6.4197951239539 1.000728613351765 0.4590788708431638 0.7871343818164667 0.1326038115232777 0.0013845547932519022 9.643743275141409e-05 0.12855106062435498 0.04279769613944013 2.7999737597453955e-11 10.552846038676059 -0.5416497425086012 ICHQIEYYFGDFNLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICHQIEYYFGDFNLPR 16 0 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 0 172027000.0 47829900.0 69099500.0 55097600.0 False True 61916748.4182819 65254052.08165771 45070402.149116985 1.0 1.053899853410106 0.7279193966169134 25.88382637400146 -6.864431392449402 1.163056146579687 1.0296684641391607 0.7107374532016214 0.9588075991264525 0.028956471997485925 0.1423110869879805 0.3632994828161493 0.01937942148061459 0.04549045375262001 1.3663709107082322e-07 6.864431392449402 -0.3189310109375393 ICIQAILQDKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICIQAILQDKPK 12 1 Q6NUQ4-2;Q6NUQ4;H7C0H8 Q6NUQ4-2 TMEM214 Transmembrane protein 214 0 4627600.0 1277000.0 1487100.0 1863500.0 False True 1674159.3664855927 1265230.4766703981 1670682.8959542238 1.0 0.7557407627963035 0.9979234530469661 20.675005436695685 -10.86394948819293 9.394878087842349 1.006491118486601 0.8768321079216348 0.25643025535282526 0.09887066927477224 0.013879191014805139 0.00020098911774112135 0.09884099133888055 0.031910371294131185 1.3678879122875813e-11 10.86394948819293 -0.1296590105649662 ICIQAILQDKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICIQAILQDKPK 12 1 Q6NUQ4-2;Q6NUQ4;H7C0H8 Q6NUQ4-2 TMEM214 Transmembrane protein 214 0 4350900.0 1277000.0 1329100.0 1744800.0 False True 1749141.409627412 1270375.9672540503 1332714.1752839722 1.0 0.7262854565455948 0.7619247751774719 20.738215498218576 -10.351263826151651 8.645830033407506 1.0000006297946025 0.7441051159410232 0.9856608171774474 0.01454969090476072 1.7662879136250193e-07 1.3257071627328369e-08 0.014087712276746798 0.004695892547216982 4.453856023899901e-11 10.351263826151651 -0.2558955138535792 ICIVIEPAQLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICIVIEPAQLLK 12 0 Q68CZ2;Q68CZ2-2;E9PCX8;Q68CZ2-3;C9JHU5;Q68CZ2-4 Q68CZ2 TNS3 Tensin-3 0 1733370.0 588820.0 838450.0 306100.0 False True 771948.7221409914 713356.5282525026 274427.70831853413 1.0 0.9240983342442954 0.3554999191622623 19.558145491917337 -6.931340372120339 0.7357102035619641 1.0082311141499372 0.23468412972299457 0.9967951051590451 0.016281787653296145 0.09194793429334298 0.07431523413372458 0.014953505442919101 0.05107448577532936 1.1712770340219369e-07 6.931340372120339 -0.7735469844269426 down ICIVIEPAQLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ICIVIEPAQLLK 12 0 Q68CZ2;Q68CZ2-2;E9PCX8;Q68CZ2-3;C9JHU5;Q68CZ2-4 Q68CZ2 TNS3 Tensin-3 0 30596200.0 9459300.0 12733000.0 8403900.0 False True 14350449.667461773 10460696.666616913 6742865.4814397795 1.0 0.7289455667954091 0.469871372513752 23.774592608279963 -6.971674907153988 0.21444088151080704 1.128186426147445 0.0633616799697271 0.9999926652070172 0.000586159029399611 0.07576288139952492 0.007051880194160341 0.0074914114985394015 0.026577277789046352 1.0673948248594112e-07 6.971674907153988 -1.0648247461777178 down ICIVIEPAQLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICIVIEPAQLLK 12 0 Q68CZ2;Q68CZ2-2;E9PCX8;Q68CZ2-3;C9JHU5;Q68CZ2-4 Q68CZ2 TNS3 Tensin-3 0 2873620.0 588820.0 0.0 2284800.0 False True 806522.6662621864 0.0 1745177.296933073 1.0 0.0 2.1638292015041105 19.621355553440228 -6.781033045096715 1.5318095669607412 0.43454035415693587 2.1815464843734884 0.771062708035455 0.4230777169396334 0.2489584415993341 1.1538982904607362 0.21752135175142748 0.5128253848941235 1.6556439821381944e-07 6.781033045096715 1.7470061302165525 ICIVIEPAQLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICIVIEPAQLLK 12 0 Q68CZ2;Q68CZ2-2;E9PCX8;Q68CZ2-3;C9JHU5;Q68CZ2-4 Q68CZ2 TNS3 Tensin-3 0 19864000.0 9459300.0 5626800.0 4777900.0 False True 12245250.320679206 5313663.633645277 3908371.2253939565 1.0 0.4339367097030111 0.3191744654491613 23.545718930372413 -13.999999999999998 0.22433485683174248 4.482235963848644 0.26028083797624624 0.9995026028032438 0.006637315930221964 13.12119447314011 0.15001161099380161 20.288324221746258 0.06174459497920115 1.0000000000000041e-14 13.999999999999998 -4.221955125872397 ICIVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICIVTK 6 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 6728400.0 1475700.0 2300800.0 2951900.0 False True 1934656.9906991292 1957529.6084481562 2646465.7046242403 1.0 1.0118225700261014 1.367925020997073 20.883646372550082 -6.91396061613788 0.8683420742781792 0.9903067234085973 1.418065543245448 0.9923319291783901 0.014949802124709186 0.10185695261991533 0.12499693745033524 0.012484491771719062 0.0354854806366469 1.2191001476358803e-07 6.91396061613788 0.4277588198368508 ICIVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICIVTK 6 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 6999500.0 1475700.0 2665500.0 2858300.0 False True 2021306.1692930076 2547729.396370231 2183228.408536328 1.0 1.2604371544867696 1.0801077252437992 20.946856434072973 -10.309200407613814 3.9717432314870362 0.9996928826061822 1.1702724398794095 0.5431203351060399 0.07361918125570996 52306751.84472626 71.81471523379057 146967.1406188777 0.025201803892441352 4.906813962311101e-11 10.309200407613814 0.17057955727322738 ICIVTK(ub)EGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICIVTKEGIR 10 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 21131400.0 4607500.0 8482100.0 8041800.0 True False 6040477.11909347 7216603.742966836 7209711.678392628 1.0 1.1947075703930279 1.1935665902289903 22.526231077511035 -9.965418772647102 4.739104074999502 0.9999975727171754 1.1941370803222007 0.9999740906809691 0.0004658032398554072 319918.85098229063 0.08093440130763788 8.473960497371523 0.00015945683286181617 1.082882230783405e-10 9.965418772647102 0.1941395076050253 ICIVTK(ub)EGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ICIVTKEGIR 10 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 26081850.0 11300650.0 7959100.0 6822100.0 True False 10941917.051413057 11137210.13615818 5035187.3513869485 1.0 1.0178481598633489 0.46017414752168095 23.383362188290086 -6.899504502592392 0.9643755922000263 1.0235023305662838 0.4022183881128066 0.9863187428497113 0.030269373839107067 0.11177160161049118 0.1794755566564096 0.023562188569569285 0.06115511198873433 1.2603625708890244e-07 6.899504502592392 -0.6212839424534773 down ICIVTK(ub)EGIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ICIVTKEGIR 10 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 216771600.0 18134000.0 43904600.0 154733000.0 True False 27510603.772980224 36069481.101794474 124149954.72811672 1.0 1.3111119406699618 4.512803708439567 24.713484466923667 -6.925731894330807 0.7810312099279928 0.9428466648462059 5.103933965274165 0.9956308167890515 0.1049473167689218 0.0949154443986511 0.08898682347005708 0.09328689620517007 0.29678647752265896 1.1865009920391279e-07 6.925731894330807 4.161087300427959 up ICIVTK(ub)EGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICIVTKEGIR 10 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 19666900.0 4607500.0 6836100.0 8223300.0 True False 6311017.263005712 6534058.49804034 6281125.904179676 1.0 1.0353415663021657 0.9952636227124184 22.589441139033926 -6.67389982228513 1.9234643853623015 1.0224826326030199 0.9954224116372055 0.2964029153349196 0.014999044578247274 0.45226688160832534 3.229466329535231 0.006269401452918659 0.01666606611689347 2.1188498291274686e-07 6.67389982228513 -0.027060220965814397 ICIVTK(ub)EGIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ICIVTKEGIR 10 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 36211040.0 11300650.0 11449000.0 13461390.0 True False 9396991.178678783 11387321.964551438 16276104.410565007 1.0 1.2118051137888262 1.7320548781076357 23.163767463724362 -6.955838925432496 0.4905767726101278 0.9886740135469271 1.9772684219623085 0.9995833851364399 0.006277970717736526 0.0812224538755884 0.026889214489783535 0.0074998208452431775 0.04290865476784433 1.1070342934685728e-07 6.955838925432496 0.9885944084153814 ICIVTK(ub)EGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICIVTKEGIR 10 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 147481400.0 18134000.0 46888200.0 82459200.0 True False 23474820.47458023 44278830.45195966 67452471.70284139 1.0 1.8862265847744015 2.873396700770618 24.484610789016116 -6.969731473163595 0.2645217039424985 0.7377128901017065 4.051372521375214 0.9999802117362124 0.00340382634736899 0.07638995378445088 0.009341493051564065 0.02002104185497884 0.0925236846687813 1.0721820368002008e-07 6.969731473163595 3.3136596312735076 ICK(ub)GDHWTTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICKGDHWTTR 10 1 O75821;K7EL20;K7ER90;K7ENA8 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 1 5839800.0 2142200.0 2503800.0 1193800.0 True False 2808444.945094312 2130242.799735959 1070277.0277382082 1.0 0.7585132845338445 0.3810924011908186 21.421340090874157 -6.964565578107718 0.3654328992526879 1.0305691039121336 0.09599286004329026 0.9999039059813587 0.0024966700120902154 0.07810870303250625 0.015381728651129519 0.005011972648373905 0.032134839056335684 1.0850117013927327e-07 6.964565578107718 -0.9345762438688434 down ICK(ub)LLQAEDLGPDTLDSLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ICKLLQAEDLGPDTLDSLQR 20 1 A0A3B3ISJ0;O43299-2;O43299;A0A3B3IRY2;A0A3B3ITJ1 A0A3B3ISJ0 AP5Z1 AP-5 complex subunit zeta-1 1 54720700.0 5858700.0 12175000.0 36687000.0 True False 8888076.228342306 10002276.12629082 29435798.36951667 1.0 1.1253589493748437 3.3118300983571416 23.083439759338738 -6.918689674869435 0.834385810573362 0.9494407935878534 3.654007998066659 0.9938091514023573 0.08352042862493209 0.09894899740050066 0.1096540839981255 0.07146645757119738 0.21146698738920947 1.205897306534589e-07 6.918689674869435 2.704567204478806 up ICK(ub)LLQAEDLGPDTLDSLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICKLLQAEDLGPDTLDSLQR 20 1 A0A3B3ISJ0;O43299-2;O43299;A0A3B3IRY2;A0A3B3ITJ1 A0A3B3ISJ0 AP5Z1 AP-5 complex subunit zeta-1 1 35014400.0 5858700.0 8502700.0 20653000.0 True False 7584202.6422423795 8029517.270526002 16894365.917675424 1.0 1.0587160772581834 2.2275731167278465 22.854566081431187 -6.917335541050807 0.8442627558912599 0.9716511886323549 2.404969157330632 0.9934080080589446 0.04590157391007715 0.09976479970157853 0.11392868264796185 0.039000761185060344 0.11400730972774052 1.2096631723487494e-07 6.917335541050807 1.433317968698277 up ICK(ub)TIVEAASDEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ICKTIVEAASDEER 14 1 Q9NWY4 Q9NWY4 C4orf27 UPF0609 protein C4orf27 1 5072300.0 2609700.0 1286500.0 1176100.0 True False 2526856.5019775573 1800206.1590088694 868044.1277562917 1.0 0.7124291219544917 0.343527274729272 21.268912306514025 -7.0006637392126745 0.3127459441380737 1.0561938146751355 1.629803540508448e-13 0.9999586531176783 0.0017276993992543538 0.07369316512177507 0.01175009847889622 0.005769745568658662 0.031417314507852415 9.984728512634502e-08 7.0006637392126745 -1.0561938146749725 down ICK(ub)TIVEAASDEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ICKTIVEAASDEER 14 1 Q9NWY4 Q9NWY4 C4orf27 UPF0609 protein C4orf27 1 4171670.0 2609700.0 867150.0 694820.0 True False 2170081.179312521 862478.4908342009 840103.6495152995 1.0 0.3974406575460154 0.38713005648085624 21.0493175819483 ICLDILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICLDILK 7 0 P61088;F8VSD4;F8VV71;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 0 31327000.0 8833300.0 9237700.0 13256000.0 False True 11580541.841798875 7859471.168272572 11884396.280530827 1.0 0.6786790528146577 1.0262383611132269 23.465199421354587 -11.865405052366455 17.181242950194 0.9019977792184145 0.8672128363407556 0.0 0.161726658174106 0.0 0.0 0.0 0.04705302338348289 1.3633110275102308e-12 11.865405052366455 -0.034784942877658875 ICLDILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ICLDILK 7 0 P61088;F8VSD4;F8VV71;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 0 16752300.0 8928900.0 3982600.0 3840800.0 False True 8645456.956932763 5572872.948984628 2834779.258469827 1.0 0.6446013179807413 0.32789235694437496 23.043510789071213 -7.491760282272383 0.2537575143672712 1.128264909814558 5.42961589277034e-13 0.9998632976776154 0.003209890181139279 0.12558589023294256 0.02461382749526266 0.025837268227834918 0.06437323998118955 3.222847216899672e-08 7.491760282272383 -1.1282649098140152 down ICLDILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ICLDILK 7 0 P61088;F8VSD4;F8VV71;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 0 47836600.0 7902000.0 35713000.0 4221600.0 False True 11987911.713581666 29339736.12305743 3387198.909606989 1.0 2.4474434600495987 0.2825512057925379 23.515077028313556 -6.726488047351076 1.7358430788272596 1.8744244639940197 0.28458148227463714 0.5430547698794097 0.6086541775121774 0.3428296257028523 2.0220259152094187 0.2780461227919796 0.6927634612058036 1.877206082113413e-07 6.726488047351076 -1.5898429817193827 ICLDILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICLDILK 7 0 P61088;F8VSD4;F8VV71;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 0 65167300.0 8833300.0 22296000.0 34038000.0 False True 12099209.72095677 21310888.996987663 25998925.43461482 1.0 1.7613455331777206 2.1488118674050805 23.52840948287748 -9.742416770609232 0.16918498551508282 4.1181297372216e-13 2.636854263326795 0.9996492090526191 0.00893782128414757 1.223921894111269 0.07289179158683719 0.8601601533635321 0.28393551297950564 1.8096026742663677e-10 9.742416770609232 2.6368542633263834 ICLDILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ICLDILK 7 0 P61088;F8VSD4;F8VV71;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 0 16808200.0 8928900.0 2030100.0 5849200.0 False True 7424775.967338616 2019163.4483566987 7072240.676354873 1.0 0.2719494106271951 0.9525190669005319 22.82391606450549 -10.943486977445316 10.019061299780233 1.1052839136389547 0.6122342387641938 0.3020878461858266 0.2778413987151686 0.12072050923105304 0.0006809293687897885 0.049702226680641316 0.08967292584256857 1.1389719340524848e-11 10.943486977445316 -0.4930496748747609 ICLDILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICLDILK 7 0 P61088;F8VSD4;F8VV71;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 0 20070500.0 7902000.0 6962600.0 5205900.0 False True 10229294.77170691 6575125.189382701 4258479.617044812 1.0 0.6427740461218074 0.41630236610477706 23.286203350406005 -8.636473413618578 0.14764534897030504 1.4473764729168015 1.784433159511531e-13 0.9998926221799381 0.0024898350831122533 0.221581536894719 0.039517257186066086 0.1953884147095305 0.15487092039977865 2.309545838996002e-09 8.636473413618578 -1.447376472916623 ICLDILK(ub)DK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICLDILKDK 9 1 P61088;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 1 593440000.0 265300000.0 175370000.0 152770000.0 True False 347810869.16885436 149205479.5869058 136962825.87331748 1.0 0.42898452237405466 0.3937853529437147 28.37372777699638 -13.950315925901858 0.3965804988403016 9.999999999999515 0.391527777573075 0.9998320317345986 0.0036009723806228215 25.193919003971658 0.20697022716678456 194.5649894026954 0.009096333667012013 1.1212025429619553e-14 13.950315925901858 -9.60847222242644 ICLDILK(ub)DK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ICLDILKDK 9 1 P61088;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 1 514451000.0 212850000.0 229100000.0 72501000.0 True False 206093193.25819963 320580824.7407167 53510813.1166217 1.0 1.5555138899666792 0.2596437673202617 27.618721616160425 -6.790220857272591 1.4955232839895456 1.3103846218384543 0.2457908957241971 0.8020243865679514 0.23618886796249416 0.23501849676256367 1.0384271663659532 0.12431034455636822 0.2909850704601353 1.620985547409434e-07 6.790220857272591 -1.064593726114257 down ICLDILK(ub)DK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ICLDILKDK 9 1 P61088;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 1 1870970000.0 746920000.0 652360000.0 471690000.0 True False 1133132247.166339 535941261.08805627 378460264.750929 1.0 0.47297326717892124 0.33399478807293415 30.07766910102023 -13.999999999999961 0.1871108565972966 3.7975589058346357 0.23133915534999283 0.9994912597050908 0.006470365249943769 12.305094841438093 0.1371684822446833 12.539128826009964 0.09781994143980766 1.00000000000009e-14 13.999999999999961 -3.5662197504846427 ICLDILK(ub)DK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICLDILKDK 9 1 P61088;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 1 623820000.0 265300000.0 173570000.0 184950000.0 True False 363388579.4629222 165901103.48076543 141268619.16481602 1.0 0.4565391232877006 0.38875360192553915 28.43693783851927 -13.999999999999998 0.2935531290040421 5.7780421091170355 0.37093429694047964 0.9996354166333887 0.005223567717777578 16.1804900435962 0.17189866468630383 46.784501436351384 0.025196938220580428 1.0000000000000041e-14 13.999999999999998 -5.407107812176556 ICLDILK(ub)DK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ICLDILKDK 9 1 P61088;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 1 642700000.0 212850000.0 334920000.0 94930000.0 True False 176994205.85380334 333115719.48358524 114779424.0932722 1.0 1.8820713247457252 0.6484925511520961 27.3991268915947 -6.7147495778544934 1.7783826365091875 1.5396243669001386 0.6509770368076095 0.48761212503620655 0.37143591983771695 0.36558972929712 2.2566922079161333 0.16603589912401936 0.41938069597939437 1.9286366798297338e-07 6.7147495778544934 -0.888647330092529 ICLDILK(ub)DK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICLDILKDK 9 1 P61088;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 1 1861020000.0 746920000.0 766640000.0 347460000.0 True False 966902663.9943457 723975810.0692792 284225845.2406672 1.0 0.748757695090509 0.2939549717098818 29.84879542311268 -6.961946941764769 0.4070682815335929 1.0231330341936622 0.0027818034349489716 0.9998357266164343 0.003745196996539188 0.07901285705871237 0.018614688272704884 0.005852685158690875 0.03800944497177883 1.0915736870625167e-07 6.961946941764769 -1.0203512307587133 down ICLDILKDK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICLDILKDK 9 1 P61088;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 1 337342000.0 140950000.0 99765000.0 96627000.0 True False 184786814.96174186 84880450.88092421 86628964.95163347 1.0 0.4593425721337196 0.46880490347522397 27.461286579338108 -10.407230604928088 5.948689556469137 1.0001595526161429 0.46407373780447164 0.99976625252365 0.003862980593972834 8.176675527630266e-06 8.14785268184306e-07 0.003741410364884837 0.0012467716255981148 3.915339222952339e-11 10.407230604928088 -0.5360858148116712 ICLDILKDK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICLDILKDK 9 1 P61088;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 1 340124000.0 140950000.0 99832000.0 99342000.0 True False 193063024.03052762 95421092.13972338 75879465.61271234 1.0 0.49424840732130637 0.39302950937261855 27.524496640861 -13.999999999999998 0.2261629098919343 4.137006054101979 0.3419841809350356 0.9995048004693712 0.005908333409041631 13.174641153323009 0.15060694108981207 18.51941620596408 0.05382500169434823 1.0000000000000041e-14 13.999999999999998 -3.795021873166944 ICLDILKDK(ub)WSPALQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICLDILKDKWSPALQIR 17 2 P61088;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 1 23094300.0 5318900.0 12042000.0 5733400.0 True False 7285441.06786784 11509944.622431183 4379289.003079515 1.0 1.5798555660816962 0.6011014243728087 22.7965848864545 -6.746178836179274 1.6638501421119778 1.3425167960932398 0.5996916346729191 0.632433208778354 0.24362751841251573 0.3067519165928813 1.6695564619121444 0.11572620374389392 0.28210338752536895 1.793994733655068e-07 6.746178836179274 -0.7428251614203207 ICLDILKDK(ub)WSPALQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICLDILKDKWSPALQIR 17 2 P61088;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 1 546830000.0 157440000.0 180570000.0 208820000.0 True False 203809183.60637 170521120.7662132 170816902.6741386 1.0 0.836670447076378 0.8381217158695285 27.602643819654936 -10.215613981113401 7.407166767025842 1.000000251798394 0.8373960814729535 0.9999402538050008 0.0005924780038072433 2.4635005363500796e-09 2.608168492865895e-10 0.0005736652494450253 0.00019122145347830766 6.08675777100792e-11 10.215613981113401 -0.1626041703254404 ICLDVLK(ub)LPPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICLDVLKLPPK 11 1 Q9NPD8 Q9NPD8 UBE2T Ubiquitin-conjugating enzyme E2 T 1 223418100.0 92232200.0 92890900.0 38295000.0 True False 120917307.37789522 79031939.80589217 34332600.75157875 1.0 0.6536032063540634 0.2839345458155237 26.849445517178072 -7.366003662154522 0.31383824519774434 1.0716569526357147 2.662076593941791e-12 0.9997752689165555 0.0043831338368829345 0.11215697750717096 0.025810798937765733 0.01562910974565941 0.05481251589304186 4.30522980124778e-08 7.366003662154522 -1.0716569526330526 down ICLDVLK(ub)LPPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ICLDVLKLPPK 11 1 Q9NPD8 Q9NPD8 UBE2T Ubiquitin-conjugating enzyme E2 T 1 206442100.0 75324200.0 99030500.0 32087400.0 True False 72933074.50138251 138573895.08723512 23682747.338633813 1.0 1.9000144452241394 0.32471889469276227 26.12006987654156 -6.751736581015117 1.6431055781821435 1.5281307333989582 0.32111933298992124 0.6564313520362537 0.3782346826331565 0.2970796751606303 1.5785050990783411 0.18179028337407074 0.44059011687773303 1.7711829340709003e-07 6.751736581015117 -1.207011400409037 ICLDVLK(ub)LPPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ICLDVLKLPPK 11 1 Q9NPD8 Q9NPD8 UBE2T Ubiquitin-conjugating enzyme E2 T 1 326424300.0 112476000.0 131239000.0 82709300.0 True False 170634315.0970398 107818375.07501273 66361770.60222604 1.0 0.631868068352467 0.3889122218147392 27.346332565438953 -8.337856993353764 0.16723280559564216 1.3583540073414144 1.2135777532165319e-09 0.9998751522390801 0.002806942754442191 0.09971937536786837 0.03743486005439539 0.13481199246490091 0.13044372681683672 4.593492447394162e-09 8.337856993353764 -1.3583540061278367 down ICLDVLK(ub)LPPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICLDVLKLPPK 11 1 Q9NPD8 Q9NPD8 UBE2T Ubiquitin-conjugating enzyme E2 T 1 216521500.0 92232200.0 55331600.0 68957700.0 True False 126332936.8214856 52886866.9548674 52671311.488411136 1.0 0.41863086765408647 0.41692461850101836 26.912655578700964 ICLDVLK(ub)LPPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ICLDVLKLPPK 11 1 Q9NPD8 Q9NPD8 UBE2T Ubiquitin-conjugating enzyme E2 T 1 172350600.0 75324200.0 54942800.0 42083600.0 True False 62635409.727850795 54646812.231108055 50883086.187418394 1.0 0.8724587652343461 0.8123693356282662 25.900475151975836 -13.999999981330356 0.10025075585580397 1.6294068277025975 0.6848813177701673 0.9997924556365966 0.0011270324346944905 12.078484701302669 0.09434332001902995 1.5718007980130924 0.11368572299696074 1.000000042988444e-14 13.999999981330356 -0.9445255099324302 ICLDVLK(ub)LPPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICLDVLKLPPK 11 1 Q9NPD8 Q9NPD8 UBE2T Ubiquitin-conjugating enzyme E2 T 1 326228200.0 112476000.0 171524000.0 42228200.0 True False 145602399.23342243 161978538.61828622 34543100.89792196 1.0 1.1124716314503196 0.23724266275684233 27.117458887531402 -6.874619132442905 1.1094234297657408 1.0657782487664158 0.18128867542006968 0.9690772498146472 0.06836959104627167 0.1325005120407558 0.3020297579130008 0.04768142103976023 0.1138805024557651 1.3346914166862292e-07 6.874619132442905 -0.8844895733463461 down ICLEIMQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICLEIMQR 8 0 A0A024R4E5;Q00341;Q00341-2;C9JIZ1;C9J5E5;H7C0A4;C9JZI8;C9JES8;C9JHS7;C9JHZ8 A0A024R4E5 HDLBP Vigilin 0 21779900.0 6998700.0 7324800.0 7456400.0 False True 9175363.475507202 6231968.391846776 6684883.254839321 1.0 0.6792067048332688 0.7285687670776213 23.129333879751417 -10.259830965881529 5.513364429716232 1.0000245829937184 0.7038877359554789 0.9795837179031409 0.020151977525069663 6.089867156829504e-06 8.175427707468986e-07 0.019513686286282958 0.006504022778972333 5.4975480528141633e-11 10.259830965881529 -0.2961368470382395 ICLEIMQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ICLEIMQR 8 0 A0A024R4E5;Q00341;Q00341-2;C9JIZ1;C9J5E5;H7C0A4;C9JZI8;C9JES8;C9JHS7;C9JHZ8 A0A024R4E5 HDLBP Vigilin 0 10238000.0 5261800.0 1808100.0 3168100.0 False True 4375419.83726353 1798359.4064202495 3830535.0623606434 1.0 0.4110141365416895 0.8754668591429005 22.06099002468691 -9.97409644806305 6.892352229210626 1.0000000303030905 0.6432404978423105 0.44030762073235363 0.18961203000323482 8.831897619207522e-08 1.3098398298182423e-08 0.18359107502505317 0.061197019536925266 1.0614598021642329e-10 9.97409644806305 -0.35675953246077996 ICLGNTYHLGLRPGPELIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICLGNTYHLGLRPGPELIQK 20 1 Q9BXR0;K7ESP6;K7EJ21;Q9BXR0-2 Q9BXR0 QTRT1 Queuine tRNA-ribosyltransferase 0 23278800.0 5168500.0 11678000.0 6432300.0 False True 6775953.551825201 9935687.92048748 5766747.298978451 1.0 1.4663158247020684 0.8510606300459503 22.69199255456378 -6.704039917466737 1.8166126924239274 1.2884109469905467 0.8527542371450375 0.43672021009339534 0.1966960387720492 0.3871673275344557 2.4867335681521565 0.08629351378891836 0.2208117917991385 1.9767879385325207e-07 6.704039917466737 -0.4356567098455092 ICLGNTYHLGLRPGPELIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICLGNTYHLGLRPGPELIQK 20 1 Q9BXR0;K7ESP6;K7EJ21;Q9BXR0-2 Q9BXR0 QTRT1 Queuine tRNA-ribosyltransferase 0 29606800.0 5168500.0 7409300.0 17029000.0 False True 7079434.123460669 7081932.626721413 13007100.923263866 1.0 1.0003529241486213 1.8373079961517533 22.75520261608667 -6.906986328529384 0.9160126959320012 0.9715517828259946 1.9387778405687994 0.9897336424462173 0.0399848675890436 0.10644505625630493 0.1498272264225981 0.03225590684443461 0.08728705175331075 1.2388355841193635e-07 6.906986328529384 0.9672260577428048 ICLSISGHHPETWQPSWSIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ICLSISGHHPETWQPSWSIR 20 0 Q9Y385 Q9Y385 UBE2J1 Ubiquitin-conjugating enzyme E2 J1 0 24385500.0 4249100.0 5883400.0 14253000.0 False True 6446195.35082002 4833461.30278599 11435888.30268818 1.0 0.7498161380062932 1.7740523952991 22.620016479004413 -6.842135896657091 1.272435693181843 0.866920279357251 1.8091891860237588 0.9280583917209726 0.11694174696484863 0.1663252559242093 0.5221836546200832 0.07203726553004622 0.16606745106846976 1.4383484290214554e-07 6.842135896657091 0.9422689066665078 ICLTDHFKPLWAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICLTDHFKPLWAR 13 1 Q9Y3C8 Q9Y3C8 UFC1 Ubiquitin-fold modifier-conjugating enzyme 1 0 32298900.0 11860000.0 9781900.0 10657000.0 False True 15548574.85240339 8322478.649547561 9554315.869162409 1.0 0.5352566861303775 0.6144817746872517 23.890279016426327 -10.765731407391453 7.038373730457971 1.009542290434369 0.5748692304088145 0.9746151373233166 0.03234350696519207 0.004836044940597398 0.00016096499396534147 0.031271530720221034 0.010438821986177712 1.7150176448326533e-11 10.765731407391453 -0.4346730600255544 ICLTDHFKPLWAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ICLTDHFKPLWAR 13 1 Q9Y3C8 Q9Y3C8 UFC1 Ubiquitin-fold modifier-conjugating enzyme 1 0 30564100.0 16406000.0 3251000.0 10907100.0 False True 15885200.51019036 4549141.253741037 8050203.3040138045 1.0 0.28637606751156597 0.5067737923011798 23.92117996472763 -10.214418335983515 6.452924827738366 1.0000051442597038 0.3965749299067829 0.9090473637496039 0.08997699436748609 6.659117758777483e-06 8.106608249529597e-07 0.08712059223101817 0.029039950060589178 6.103538157773655e-11 10.214418335983515 -0.6034302143529209 ICLTDHFKPLWAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ICLTDHFKPLWAR 13 1 Q9Y3C8 Q9Y3C8 UFC1 Ubiquitin-fold modifier-conjugating enzyme 1 0 49730500.0 14118300.0 18292200.0 17320000.0 False True 21418493.285985813 15027813.99238906 13896694.408374313 1.0 0.7016279712925375 0.6488175532621132 24.35235365945883 -13.999999999999998 0.24357508295154387 3.0097066045766163 0.6262466622620861 0.9995310389993807 0.003348196986019055 13.752354103188111 0.15618831800336136 13.471473399582791 0.02527404848013638 1.0000000000000041e-14 13.999999999999998 -2.38345994231453 ICLTDHFKPLWAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICLTDHFKPLWAR 13 1 Q9Y3C8 Q9Y3C8 UFC1 Ubiquitin-fold modifier-conjugating enzyme 1 0 52243000.0 11860000.0 14034000.0 26349000.0 False True 16244962.50444879 13413931.47576807 20125908.87468901 1.0 0.8257286818664294 1.2389015283462426 23.953489077949218 -6.792132075852544 1.4879045199267067 0.9028678424459246 1.2435507817620726 0.8081149789378986 0.07418918316378392 0.23219616672145105 1.0154771516869783 0.03924286623056377 0.0917325129560013 1.6138676793840667e-07 6.792132075852544 0.340682939316148 ICLTDHFKPLWAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ICLTDHFKPLWAR 13 1 Q9Y3C8 Q9Y3C8 UFC1 Ubiquitin-fold modifier-conjugating enzyme 1 0 32039100.0 16406000.0 2206800.0 13426300.0 False True 13642315.909032151 2194911.530384497 16233677.253802821 1.0 0.1608899504321927 1.1899502519990033 23.701585240161908 -6.689929985742686 1.8668787401479383 0.47388180354583437 1.1863668184731075 0.36996182891152496 0.3548919019264122 0.41684120673869723 2.816707021677232 0.15208700608173928 0.3960488147421812 2.0420671275056448e-07 6.689929985742686 0.7124850149272732 ICLTDHFKPLWAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICLTDHFKPLWAR 13 1 Q9Y3C8 Q9Y3C8 UFC1 Ubiquitin-fold modifier-conjugating enzyme 1 0 64081300.0 14118300.0 30513000.0 19450000.0 False True 18276417.66329911 28814924.72691735 15910299.573853074 1.0 1.576617762723853 0.8705370968733419 24.12347998155128 -6.689650172139961 1.8682700924090145 1.361631359689651 0.8730274004825006 0.3685665549956014 0.24388712938901222 0.41739069203278323 2.8245086745539667 0.10445716634395875 0.2720724404398036 2.0433832443288894e-07 6.689650172139961 -0.4886039592071504 ICPIDITLAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICPIDITLAQR 11 0 P41214;P41214-2;A0A087X1L6 P41214 EIF2D Eukaryotic translation initiation factor 2D 0 8414400.0 1446900.0 2376700.0 4590800.0 False True 1896899.9117995296 2022105.6243040415 4115788.0540631386 1.0 1.066005439573105 2.1697444490672253 20.855212127588647 -6.919154204385317 0.830981194276277 0.9748965638290333 2.344312015707285 0.9939426469243463 0.041758548394972374 0.09867185170164074 0.10821357756661913 0.03581908270447389 0.10644193352903654 1.2046081457569512e-07 6.919154204385317 1.3694154518782518 up ICPIDITLAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICPIDITLAQR 11 0 P41214;P41214-2;A0A087X1L6 P41214 EIF2D Eukaryotic translation initiation factor 2D 0 6452300.0 1446900.0 1782100.0 3223300.0 False True 1981858.031002269 1703360.9293833738 2462022.925947287 1.0 0.8594767651050903 1.2422801671127717 20.91842218911154 -6.8073746322980195 1.4258083953840337 0.9231751969170737 1.2485653265888275 0.8527865132228349 0.060663747056230885 0.21040887785022025 0.8435716295818849 0.033461537897691185 0.07749000429232654 1.5582077774450823e-07 6.8073746322980195 0.32539012967175374 ICSIYTQSGENSLVQEGSEASPIGK(ub)SPYTLDSLYWSVKPASSSFGSEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ICSIYTQSGENSLVQEGSEASPIGKSPYTLDSLYWSVKPASSSFGSEAK 49 2 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 113084000.0 10566000.0 36064000.0 66454000.0 True False 16029394.478069315 29628097.43068191 53319337.772177115 1.0 1.8483603651540126 3.3263475950464754 23.934216591888248 -6.962651410752906 0.3962995810608921 0.9153618093725018 4.31299185768865 0.9998562487601977 0.011525059038412775 0.07876723912535222 0.017728775563957057 0.019031738181982817 0.12400640005202275 1.0898044809157399e-07 6.962651410752906 3.3976300483161483 ICSIYTQSGENSLVQEGSEASPIGK(ub)SPYTLDSLYWSVKPASSSFGSEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICSIYTQSGENSLVQEGSEASPIGKSPYTLDSLYWSVKPASSSFGSEAK 49 2 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 112962000.0 10566000.0 20923000.0 81473000.0 True False 13677895.286997607 19758616.657204848 66645749.9835749 1.0 1.4445655740607737 4.872515002138469 23.705342913980697 -6.930787901792721 0.7402969087745076 0.949365527388471 5.590584927035394 0.9966908296784058 0.09953508143446102 0.0922307940512044 0.07569123455043503 0.09110989773625071 0.30883745361027853 1.1727679752997715e-07 6.930787901792721 4.641219399646923 up ICVANTHLYWHPK(ub)GGYIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ICVANTHLYWHPKGGYIR 18 1 Q6L8Q7;Q6L8Q7-2 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 1 102900000.0 28646000.0 40182000.0 34072000.0 True False 43458076.303120755 33011208.156601083 27337654.265711915 1.0 0.7596104329687167 0.6290580851998914 25.373120978413837 -13.999999999039277 0.07448593202541327 2.344273037406836 0.1960650186250342 0.9999084044364996 0.0014703457889714336 12.314033796236869 0.07514771385353265 2.8032302275177248 0.3961351539820958 1.0000000022121466e-14 13.999999999039277 -2.148208018781802 ICVANTHLYWHPK(ub)GGYIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICVANTHLYWHPKGGYIR 18 1 Q6L8Q7;Q6L8Q7-2 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 1 89711000.0 28646000.0 38581000.0 22484000.0 True False 37082811.69707872 36433933.43457532 18392142.705321975 1.0 0.9825019130748783 0.4959748698551587 25.144247300506287 -6.9145184375025 0.8643908141250698 1.0129977499354152 0.4266200411734484 0.9925180309531919 0.020204691652445282 0.10150563390641419 0.1231183854853186 0.016920671711905515 0.048309432172469885 1.2175353026036404e-07 6.9145184375025 -0.5863777087619668 down ICVHSHWTVCGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ICVHSHWTVCGQK 13 0 Q96GW9 Q96GW9 MARS2 Methionine--tRNA ligase, mitochondrial 0 5245900.0 1085900.0 2725300.0 1434700.0 False True 1405718.956289106 2573634.659268766 1173599.32126514 1.0 1.830831581059978 0.8348747920162305 20.422876756268845 -6.685373328100039 1.883304164845439 1.523129646660811 0.8385360642754788 0.3487074625090333 0.35172114237154384 0.42666415099411287 2.930384062827678 0.1496245276866181 0.391855736395471 2.063605477187193e-07 6.685373328100039 -0.6845935823853323 ICVQNSTFSATWNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICVQNSTFSATWNR 14 0 Q9BZE1;S4R369 Q9BZE1 MRPL37 39S ribosomal protein L37, mitochondrial 0 6667200.0 1806700.0 2926800.0 1933700.0 False True 2474685.8142316695 2797484.2983666817 1476999.8858015942 1.0 1.1304401885195408 0.5968433961626629 21.238813941780062 -6.842077707465418 1.272709117971393 1.0693828822915201 0.5785583582296732 0.9279692024670998 0.060957297430087105 0.16638496261677077 0.5226219066663694 0.037543004425800997 0.0865460969487177 1.4385411598601287e-07 6.842077707465418 -0.49082452406184696 ICYIFHETFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICYIFHETFGR 11 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 3969880.0 943200.0 2030000.0 996680.0 False True 1236544.3339617916 1727131.9128780235 893553.1144296507 1.0 1.3967407924181963 0.722621170861522 20.237882535085358 -6.747220586832309 1.659855434650119 1.234076691929055 0.7215440420745062 0.6369030551947188 0.16669791198907094 0.30498743464972194 1.6523080324735822 0.07935900739596952 0.1932486183792584 1.7896966005297903e-07 6.747220586832309 -0.5125326498545487 ICYIFHETFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICYIFHETFGR 11 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 3715700.0 943200.0 1522600.0 1249900.0 False True 1291926.529021591 1455326.4974351204 954699.362498532 1.0 1.1264777560820556 0.7389734176459325 20.30109259660825 -6.818796306035188 1.377029516947382 1.0682555663242004 0.7307273073126869 0.8815990884741072 0.0555180460484852 0.19505258776557646 0.7270732658046026 0.03168458674218799 0.07305394821901601 1.5177620653870486e-07 6.818796306035188 -0.3375282590115135 ICYQEVSQCFGVLSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ICYQEVSQCFGVLSSR 16 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 10489500.0 1155300.0 5708500.0 3625700.0 False True 1514609.4879411163 4856814.051558721 3250547.3441702356 1.0 3.2066444124556677 2.1461289989599006 20.53051444062374 -10.419222517425254 6.4140216212958325 0.9996843143241165 2.676386705707784 0.7691385592929258 0.43295360457022386 0.001954793241880528 0.00017700284081099523 0.4192752785599413 0.13973517501507893 3.808706284962581e-11 10.419222517425254 1.6767023913836676 ICYQEVSQCFGVLSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ICYQEVSQCFGVLSSR 16 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 9057300.0 1155300.0 2707700.0 5194300.0 False True 1582445.6308085741 2588064.860833492 3967513.3199664983 1.0 1.6354842216671177 2.507203560566715 20.59372450214663 -6.966700032452718 0.32756584467863087 0.8907369692564656 3.280384338743949 0.9999440216901823 0.004622498586135325 0.07738870784132781 0.012850765777385422 0.012832430330282687 0.07618433734863117 1.0796922090215262e-07 6.966700032452718 2.3896473694874834 IDAHLNK(ub)VCPTTETIYNDEFYTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDAHLNKVCPTTETIYNDEFYTK 23 1 A0AVT1;A0AVT1-2;H0Y8S8 A0AVT1 UBA6 Ubiquitin-like modifier-activating enzyme 6 1 56616000.0 11697000.0 17119000.0 27800000.0 True False 16021696.999539398 16362625.975037294 21234212.55897209 1.0 1.0212792050372503 1.325341039690274 23.933523628634642 -6.921027527934408 0.817055254768341 0.9935364614181749 1.3755540982818273 0.994461951252789 0.0110589560969425 0.09757090871123869 0.10250422782504683 0.00958065451895279 0.02898732216297025 1.1994232748021342e-07 6.921027527934408 0.3820176368636524 IDASELSFPFHESILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDASELSFPFHESILK 16 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 0 7325200.0 2464900.0 1476200.0 3384100.0 False True 2386653.0987180457 2065654.3582813016 2497702.689176147 1.0 0.8655025564422564 1.0465294225280373 21.186557454499884 -6.707765443388615 1.8034023919262934 0.9171251316694242 1.0460726486722132 0.454399147013295 0.05669669354594691 0.3795731279689302 2.405026010862276 0.025033287572229654 0.06376371997428767 1.959902904923643e-07 6.707765443388615 0.12894751700278895 IDASK(ub)NEEDEGHSNSSPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDASKNEEDEGHSNSSPR 18 1 Q14103-3;Q14103;D6RAF8;D6RD83 Q14103-3 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 25203760.0 10219400.0 9498000.0 5486360.0 True False 13397732.364810368 8080935.42291403 4918684.096081254 1.0 0.6031569524510656 0.3671281051262344 23.675485501992597 -8.992720392167605 0.1585647744324582 1.4800362927960033 2.4464168566250075e-09 0.999812797882287 0.0035728846744694587 0.46440525631883395 0.05108149423642746 0.27102964230507864 0.16387531199987443 1.0169031856097503e-09 8.992720392167605 -1.4800362903495865 IDASK(ub)NEEDEGHSNSSPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDASKNEEDEGHSNSSPR 18 1 Q14103-3;Q14103;D6RAF8;D6RD83 Q14103-3 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 18283900.0 1685100.0 9617900.0 6980900.0 True False 1631607.4228771068 13458377.626685893 5152392.86748907 1.0 8.248539101981999 3.157863095770648 20.637862545016397 -9.923911701693706 8.592946857926217 0.9999999973524041 5.703201098876324 0.5322918729761117 2.0782597768411897 9.668802084089367e-08 1.395800805561193e-08 2.012266376199663 0.6707554587332223 1.1914842292610728e-10 9.923911701693706 4.70320110152392 IDASK(ub)NEEDEGHSNSSPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDASKNEEDEGHSNSSPR 18 1 Q14103-3;Q14103;D6RAF8;D6RD83 Q14103-3 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 35711700.0 12040500.0 13279300.0 10391900.0 True False 18266318.778458603 10909505.163355544 8337936.410068428 1.0 0.5972470586805416 0.4564650661796904 24.122682580323705 -13.999999999999998 0.14654629688104165 2.937869273740807 0.29525346658491947 0.9995781730961666 0.004730574992216099 11.946385527815067 0.12037358180782065 6.599885961599177 0.1448477166449619 1.0000000000000041e-14 13.999999999999998 -2.6426158071558876 IDASK(ub)NEEDEGHSNSSPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDASKNEEDEGHSNSSPR 18 1 Q14103-3;Q14103;D6RAF8;D6RD83 Q14103-3 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 27233330.0 10219400.0 10540500.0 6473430.0 True False 13997788.348900821 10074785.85722768 4944539.158475771 1.0 0.7197412624129871 0.35323717113239833 23.73869556351549 -6.967436448572518 0.3134340014322002 1.0542215131312094 0.007048648124594532 0.9999549186293899 0.001778070594510615 0.07714364817235773 0.011993457189934269 0.0057110851344840076 0.03243212637302473 1.077862968612455e-07 6.967436448572518 -1.0471728650066148 down IDASK(ub)NEEDEGHSNSSPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDASKNEEDEGHSNSSPR 18 1 Q14103-3;Q14103;D6RAF8;D6RD83 Q14103-3 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 17722070.0 1685100.0 12882900.0 3154070.0 True False 1401235.3125874747 12813497.260644566 3813571.454228039 1.0 9.144429308581715 2.721578181744524 20.418267820450673 -6.5866310525146154 2.24046591560476 6.523898170415759 2.7389733960743534 0.0 3.53228840985351 0.6798627064674968 6.427960941604229 1.3182834699920436 3.94317131443666 2.590412621612928e-07 6.5866310525146154 -3.7849247743414054 IDASK(ub)NEEDEGHSNSSPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDASKNEEDEGHSNSSPR 18 1 Q14103-3;Q14103;D6RAF8;D6RD83 Q14103-3 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 37794500.0 12040500.0 18101800.0 7652200.0 True False 15586664.603737906 17094418.917238947 6259578.118202483 1.0 1.0967336086220436 0.4015983071003752 23.893808902416154 -6.871702097697892 1.1251116042168738 1.0553095831554102 0.35955941020081617 0.9663496730234893 0.05639623783309761 0.13523026476324262 0.31891390358675376 0.038860789367916676 0.092282205362174 1.3436863405580997e-07 6.871702097697892 -0.6957501729545941 down IDATSASVLASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDATSASVLASR 12 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 55402000.0 10149000.0 17590000.0 27663000.0 False True 13305437.28305581 14965640.565282986 24800698.122233264 1.0 1.12477630361998 1.863952126835878 23.665512589508104 -6.93610540514826 0.6948523056106584 0.990885779767282 2.042344392421332 0.9976079779150322 0.018647709457069693 0.08958909498183464 0.06304283246020292 0.017655383368657473 0.06478567454937938 1.1584961500076208e-07 6.93610540514826 1.05145861265405 IDATSASVLASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDATSASVLASR 12 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 30964400.0 8797900.0 3440500.0 18726000.0 False True 8518615.480226992 4814309.591970484 13821098.832041757 1.0 0.5651516497188107 1.6224583518439868 23.02218753943228 -6.795019041986315 1.4761040466571154 0.7585379846611338 1.635329165294055 0.8172068679587172 0.18551217366918635 0.2279513584867993 0.9809910214888149 0.09889350968965907 0.23072843068003843 1.6031750966642433e-07 6.795019041986315 0.8767911806329212 IDATSASVLASR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDATSASVLASR 12 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 89048300.0 3294600.0 82124000.0 3629700.0 False True 4998149.067522919 67468330.5622593 2912288.204045975 1.0 13.498663135250704 0.5826733386103877 22.25296249911394 -6.653674560607439 1.9957945525819338 9.08676929865086 0.6372974262499018 0.20900695028876892 5.329786936282 0.4995386547531248 3.81814016481908 2.162903105711126 5.903421336085648 2.219859252434205e-07 6.653674560607439 -8.44947187240096 IDATSASVLASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDATSASVLASR 12 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 56374000.0 10149000.0 24846000.0 21379000.0 False True 13901359.566412367 23748221.565265294 16329720.514326056 1.0 1.7083380551240706 1.1746851404218728 23.728722651030996 -10.604239924398849 5.314436318991575 0.9965190290934888 1.4415115977729709 0.4771657291124143 0.2178628901282326 0.009039888540445476 0.0006731893985090346 0.2122214912955691 0.07031494543527135 2.4874827378815024e-11 10.604239924398849 0.4449925686794821 IDCFSEVPTSVFGEK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDCFSEVPTSVFGEKLR 17 1 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 1 15777200.0 4089200.0 11688000.0 0.0 True False 5360980.79986913 9944195.95946716 0.0 1.0 1.8549210173835937 0.0 22.354065537481404 -6.790008094873572 1.5528793696359677 1.4827602388047132 2.7958030401554223e-19 0.7718960240370346 0.36204166786357395 0.2427723917412243 1.1654671693195322 0.18513851500072684 0.42328352468039565 1.621779868502949e-07 6.790008094873572 -1.4827602388047132 IDCFSEVPTSVFGEK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDCFSEVPTSVFGEKLR 17 1 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 1 21922700.0 4089200.0 6347500.0 11486000.0 True False 5601087.746474869 6067046.461624468 8773243.36159544 1.0 1.0831907544106691 1.5663463524771626 22.417275599004295 -6.936527799864093 0.6911105162294576 0.994115791281734 1.6843252106649436 0.9976728404454376 0.012045229883645453 0.08938691355138338 0.06209433589429078 0.0114369293089025 0.042259362376073896 1.1573699446738901e-07 6.936527799864093 0.6902094193832096 IDDFK(ub)AEDFQIEGYNPHPTIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDDFKAEDFQIEGYNPHPTIK 21 1 P04818;P04818-2;P04818-3 P04818 TYMS Thymidylate synthase 1 73068400.0 6860200.0 9912200.0 56296000.0 True False 10407424.947799666 8143290.465627918 45169070.92458662 1.0 0.7824500783308141 4.340081350683796 23.311109818862846 -6.892349614097273 1.0083633476964906 0.8194723187379563 4.6605560077282995 0.9823606154421155 0.21625074153838258 0.11725809442523444 0.2108698099202503 0.16287841109459245 0.40965499806999855 1.2812987011484915e-07 6.892349614097273 3.8410836889903432 up IDDFK(ub)AEDFQIEGYNPHPTIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDDFKAEDFQIEGYNPHPTIK 21 1 P04818;P04818-2;P04818-3 P04818 TYMS Thymidylate synthase 1 71109700.0 6860200.0 9286500.0 54963000.0 True False 8880664.134758767 8769698.111510426 44960297.96800442 1.0 0.9875047607290967 5.062717977592531 23.082236140955295 -6.906208912974636 0.9211732986117025 0.858202400882109 5.54878769172812 0.9894103558418123 0.19738765159789715 0.1069784166382773 0.15276415825323653 0.15863389960008023 0.42720620704534323 1.2410551669248883e-07 6.906208912974636 4.690585290846011 up IDDFKAEDFQIEGYNPHPTIK(ub)MEMAV ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDDFKAEDFQIEGYNPHPTIKMEMAV 26 2 P04818;P04818-2;P04818-3 P04818 TYMS Thymidylate synthase 1 37646100.0 16548000.0 7605100.0 13493000.0 True False 21421712.209846325 7181869.49957981 11037412.44987143 1.0 0.33526122605076913 0.515244175710575 24.35257046166347 -10.827566851260288 10.861045432409483 1.0077032266569363 0.42525270088189676 0.9314908306235576 0.07347773151125928 0.013392409435404724 0.00021262136956849524 0.06951809538273002 0.02371483587168391 1.487418397078715e-11 10.827566851260288 -0.5824505257750396 IDDIVSGHKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDDIVSGHKK 10 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 19910800.0 6358500.0 6639200.0 6913100.0 True False 8336055.075801583 5648657.239398904 6197798.727137718 1.0 0.677617552671428 0.7434930156746532 22.99093337876921 -10.803520443625388 7.144613431536677 1.011423393783053 0.7105552841730406 0.9626040078877992 0.02689354515458215 0.004913428882744608 0.00013512100076643407 0.026145356907114975 0.00867985437534782 1.572097787067903e-11 10.803520443625388 -0.3008681096100124 IDDIVSGHKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDDIVSGHKK 10 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 22809900.0 6358500.0 7233200.0 9218200.0 True False 8709409.282001471 6913613.307006237 7041051.014788354 1.0 0.7938096698812448 0.8084418571692478 23.0541434402921 -10.128528507794528 5.0934422077716635 1.0000072408382161 0.8011257635249106 0.9959564439521714 0.005973565447243749 4.911959055526165e-07 8.403618720439887e-08 0.00578409047666821 0.001927959957720126 7.438262353439196e-11 10.128528507794528 -0.19888147731330552 IDDIVSGHKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDDIVSGHKK 10 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 29942900.0 8707100.0 15614000.0 5621800.0 True False 7240339.439932589 15529884.282863677 6797292.3877336765 1.0 2.144911079335842 0.938808524672838 22.787625904316087 -6.657951448941305 1.9801347962634106 1.7382063379137696 0.9438510334196497 0.22693392128254974 0.4877171972265065 0.48932530987072187 3.6860530167935948 0.19914337594184173 0.5405525997209919 2.1981055917450694e-07 6.657951448941305 -0.7943553044941198 IDDIVSGHKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDDIVSGHKK 10 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 49453000.0 16028000.0 13769000.0 19656000.0 True False 20748561.959113907 13002743.046076246 16078809.68759155 1.0 0.6266816501162253 0.7749361001150663 24.30650801385913 -10.071457679060122 5.027970895636775 1.0000064160085997 0.7008088762732517 0.8444853068095438 0.06052462577038227 4.353138424852531e-06 8.038168026291799e-07 0.05860397319964378 0.01953423896967154 8.482860418343018e-11 10.071457679060122 -0.299197539735348 IDDLIK(ub)LHPESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDDLIKLHPESK 12 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 1 18605100.0 4098200.0 7177800.0 7329100.0 True False 5372779.8870252585 6106900.218845258 6570755.037691503 1.0 1.1366369639658658 1.2229711947737218 22.357237304000165 IDDLIK(ub)LHPESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDDLIKLHPESK 12 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 1 13365900.0 3292600.0 4828600.0 5244700.0 True False 3188078.2152781207 6756685.160816344 3870955.7323726066 1.0 2.1193599104427574 1.2141972282304603 21.604255593699502 -10.25342926108006 4.213342799888614 0.9995969699454107 1.6667785691635704 0.41979102491175935 0.36953112014939565 130566556.09416382 495.09158838125836 604017.5699010111 0.12650033097335392 5.579184698302614e-11 10.25342926108006 0.6671815992181597 IDDLIK(ub)LHPESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDDLIKLHPESK 12 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 1 58727000.0 11879000.0 16992000.0 29856000.0 True False 18021311.471227076 13959644.840898031 23954948.513650313 1.0 0.7746186987104726 1.3292566721293795 24.10320066893615 -6.7963718409879315 1.4705747723597327 0.8750710959659128 1.3362544552021418 0.8213848312161653 0.09625366567397185 0.22596997648404638 0.9650914970013059 0.05150025642834396 0.12005057658808922 1.598189080330666e-07 6.7963718409879315 0.461183359236229 IDDLIK(ub)LHPESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDDLIKLHPESK 12 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 1 16490900.0 4098200.0 5594000.0 6798700.0 True False 5613415.289690727 5346838.583115754 5192987.083621707 1.0 0.952510781259218 0.9251029570462825 22.420447365523057 -13.999999999993207 0.061566909334037655 1.2971967625335223 0.8056992917877497 0.9999500582989179 0.00021858047106119752 12.447906432093276 0.06404328496341703 0.5635341007843538 0.1115995975543295 1.0000000000156409e-14 13.999999999993207 -0.49149747074577266 IDDLIK(ub)LHPESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDDLIKLHPESK 12 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 1 14503600.0 3292600.0 7967000.0 3244000.0 True False 2737942.786912064 7924080.189674319 3922305.4014386903 1.0 2.894173036614596 1.4325739092095444 21.38466086913378 -6.580611337281083 2.2639492023748775 2.2893523124325266 1.4361621568830265 0.0 0.8227435334960524 0.6974613507257814 6.724429334716821 0.3049907169105969 0.9198038188889388 2.626568083795159e-07 6.580611337281083 -0.8531901555495001 IDDLIK(ub)LHPESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDDLIKLHPESK 12 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 1 66814000.0 11879000.0 15717000.0 39218000.0 True False 15377599.670096962 14842335.133646613 32080726.410661653 1.0 0.9651919319052624 2.0861985679758153 23.8743269910286 -6.899732771837095 0.9629448344297036 0.9530502823358108 2.2032350680304424 0.9864332066579145 0.060618755262357195 0.11160262710020631 0.17852659767080034 0.04723712904996411 0.12274047479959177 1.2597002865913788e-07 6.899732771837095 1.2501847856946315 up IDDPTDSKPEDWDKPEHIPDPDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDDPTDSKPEDWDKPEHIPDPDAK 24 2 P27797;K7EJB9;K7EL50 P27797 CALR Calreticulin 0 170402200.0 2996200.0 98437000.0 68969000.0 False True 3928047.2152420697 83750583.30442064 61832749.47736344 1.0 21.321175310582266 15.74134578561906 21.905380840317463 -9.785620299990907 9.049575476955788 1.0005442473006212 18.531260548099674 0.9293886961432246 2.277955886317883 0.0 0.0 2.2056211615899346 0.7352070976612296 1.6382482020937024e-10 9.785620299990907 17.530716300799053 IDDPTDSKPEDWDKPEHIPDPDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDDPTDSKPEDWDKPEHIPDPDAK 24 2 P27797;K7EJB9;K7EL50 P27797 CALR Calreticulin 0 148901600.0 27173500.0 17555100.0 104173000.0 False True 26310892.11652187 24564942.978637077 76886966.1769885 1.0 0.9336415834874551 2.9222485439293595 24.64915683062723 -6.8991782509119055 0.9664292946834172 0.9154464968208038 3.127551320916309 0.9861535843055342 0.10851547406621283 0.11201334047223711 0.18084259263470642 0.08434139372786915 0.21855557552181298 1.2613097390253204e-07 6.8991782509119055 2.2121048240955052 up IDDPTDSKPEDWDKPEHIPDPDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDDPTDSKPEDWDKPEHIPDPDAK 24 2 P27797;K7EJB9;K7EL50 P27797 CALR Calreticulin 0 170381200.0 2996200.0 67303000.0 100082000.0 False True 4103976.109260487 64329330.91874152 76444692.85349067 1.0 15.674879484211543 18.626982910791252 21.968590901840354 -9.113920685893566 0.6168332408491448 5.234701797407265e-14 18.345774544077667 0.9972542533776118 0.40392017828497206 0.5563186589660768 0.26820191490878975 2.366514991131029 0.5028985316721836 7.692709174671542e-10 9.113920685893566 18.345774544077614 IDDSK(ub)EAMER ddPTM_RPMI8226_Bortezomib_2h_R1 2 IDDSKEAMER 10 1 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 1 9458980.0 4480350.0 3223500.0 1755130.0 True False 4338123.741669597 4510660.36033043 1295408.8002286353 1.0 1.0397721754692109 0.29861038489650743 22.0486397746965 -6.894227432073803 0.9970687719678936 1.0358823501039731 0.22933039957624454 0.9834680526834771 0.04376749334110491 0.1157790430708884 0.20236190242795243 0.03324779831377725 0.08425101661818249 1.2757705361587677e-07 6.894227432073803 -0.8065519505277285 down IDDSK(ub)EAMER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDDSKEAMER 10 1 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 1 2584950.0 997650.0 1195500.0 391800.0 True False 829590.1783887553 1189059.6042118282 473723.56852147967 1.0 1.4333096451566492 0.571033241306634 19.662039288460523 -6.770091088385326 1.5741006777991045 1.2485135829338088 0.5661694508866404 0.7308664892123913 0.18262347438634677 0.26630633712970125 1.302251316664487 0.09144670166572902 0.2176632904458863 1.6978875022975158e-07 6.770091088385326 -0.6823441320471684 IDDSK(ub)EAMER ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IDDSKEAMER 10 1 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 1 13567440.0 4537800.0 4132130.0 4897510.0 True False 5874271.553410729 3902173.3330658055 4006213.432696196 1.0 0.6642820812054763 0.6819932303555326 22.485978528841823 -10.80581770480102 10.786381590366659 1.0026293025092938 0.6731376557827524 0.997802798148295 0.007230546362661 0.00045890414148342496 8.261429740200298e-06 0.007027309897393953 0.002333648803880555 1.5638039119135563e-11 10.80581770480102 -0.3294916467265414 IDDVVNTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDDVVNTR 8 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 7682850.0 2272600.0 709850.0 4700400.0 False True 2200457.5569583466 993296.8068188466 3469224.2310225936 1.0 0.4514046652151124 1.5765922046767584 21.069372114218986 -6.77415146982988 1.5587011730851645 0.6870019162522505 1.5839140818517243 0.7460997287603359 0.23148650574738747 0.2597895205663622 1.2461865169170583 0.11702510259691358 0.2775053715046394 1.6820872935129282e-07 6.77415146982988 0.8969121655994738 IDEELTGK(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDEELTGKSR 10 1 J3KT10;Q9BW27;Q9BW27-3;J3KRC0;J3KSH3 J3KT10 NUP85 Nuclear pore complex protein Nup85 1 7977810.0 2201110.0 2357300.0 3419400.0 True False 2885676.5255795605 2005600.0286834317 3065593.289200898 1.0 0.6950190053892565 1.0623482091726142 21.460478157061264 -6.686309187297152 1.8797698920559724 0.8081374697125784 1.061017513102737 0.35313458175536505 0.12908384351019958 0.42463111758688254 2.906189322648065 0.05499815859497672 0.14387622478764484 2.0591634109748716e-07 6.686309187297152 0.2528800433901587 IDEELTGK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDEELTGKSR 10 1 J3KT10;Q9BW27;Q9BW27-3;J3KRC0;J3KSH3 J3KT10 NUP85 Nuclear pore complex protein Nup85 1 10297880.0 2119980.0 2831800.0 5346100.0 True False 2052682.3953183817 3962552.5076419148 3945796.030437805 1.0 1.9304265076172693 1.922263297740122 20.969078990659778 -10.00678389631645 4.903758049379461 0.9999876611952466 1.9263449026948753 0.9999417610172893 0.003332616532633094 2298379.009039397 0.19079960473377808 323.92970857716256 0.0011408432731052013 9.845008686958929e-11 10.00678389631645 0.9263572414996287 IDEELTGK(ub)SR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDEELTGKSR 10 1 J3KT10;Q9BW27;Q9BW27-3;J3KRC0;J3KSH3 J3KT10 NUP85 Nuclear pore complex protein Nup85 1 34139800.0 5461000.0 11200000.0 17478800.0 True False 8284736.252577761 9201272.49400058 14024107.518769827 1.0 1.1106295014687573 1.6927645118945438 22.98202433881015 -6.9386728760651 0.6718005961781288 0.9932915842398848 1.8438009554966868 0.9979848074934685 0.013641076751423275 0.08837737969732636 0.057406985676960655 0.013148648085670326 0.05040322874253217 1.1516675336614403e-07 6.9386728760651 0.8505093712568019 IDEELTGK(ub)SR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDEELTGKSR 10 1 J3KT10;Q9BW27;Q9BW27-3;J3KRC0;J3KSH3 J3KT10 NUP85 Nuclear pore complex protein Nup85 1 8586210.0 2201110.0 1553900.0 4831200.0 True False 3014919.84976115 1485243.5599398618 3690170.0616872604 1.0 0.4926311921882523 1.2239695400126824 21.523688218584155 -6.720109169098204 1.7589546013165351 0.6913607515775352 1.2228346685761826 0.5130366649118661 0.21349941352392043 0.3550961300816189 2.147168145415577 0.09637489565373177 0.24190303359661383 1.9049818003294496e-07 6.720109169098204 0.5314739169986474 IDEELTGK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDEELTGKSR 10 1 J3KT10;Q9BW27;Q9BW27-3;J3KRC0;J3KSH3 J3KT10 NUP85 Nuclear pore complex protein Nup85 1 13288580.0 2119980.0 5230400.0 5938200.0 True False 1762857.3010380343 5202222.797046885 7179850.164865364 1.0 2.9510175293165406 4.072848188357395 20.749484266094054 -8.634083030472613 0.24847965056045931 5.105351626924019e-16 4.929679524722791 0.9992844792009286 0.03396129211182635 0.23199490551919844 0.07158683998714409 0.6334743491618716 0.4480479691748947 2.3222927670004785e-09 8.634083030472613 4.92967952472279 IDEELTGK(ub)SR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDEELTGKSR 10 1 J3KT10;Q9BW27;Q9BW27-3;J3KRC0;J3KSH3 J3KT10 NUP85 Nuclear pore complex protein Nup85 1 26726100.0 5461000.0 7648900.0 13616200.0 True False 7069372.152403371 7223231.991076527 11138191.31401019 1.0 1.0217642861849972 1.5755559438504796 22.753150660902598 -6.915189732618675 0.8596533656129606 0.9855365051576231 1.6556732550068805 0.9927365471760045 0.02269889592277589 0.10108631842295562 0.1208963440570193 0.019074402174909973 0.05475377557255397 1.215654794823807e-07 6.915189732618675 0.6701367498492573 IDEHHFVAVALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDEHHFVAVALR 12 0 Q9NRN7;E9PLW6 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 7967300.0 6328900.0 1638400.0 0.0 False True 8297249.189154793 1393957.1064331783 0.0 1.0 0.16800231916081276 0.0 22.984201684223535 -9.793551383813458 0.4390049410024761 1.2951819989652118 2.2350192313069497e-21 0.998365072426882 0.017678620290871482 1.2244482153943268 0.21455093318196794 0.5522545598370202 0.039466288591011776 1.6086020439086444e-10 9.793551383813458 -1.2951819989652118 IDEHHFVAVALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDEHHFVAVALR 12 0 Q9NRN7;E9PLW6 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 22380300.0 6328900.0 4226400.0 11825000.0 False True 8668865.362091566 4039663.6731641847 9032178.543519601 1.0 0.46599681785685526 1.0419101192892881 23.047411745746427 -11.95454211652757 14.519097783747132 0.9077957140410515 0.778558121715765 0.0 0.26838116473527956 0.0 0.0 0.0 0.07804180275749426 1.1103448523233458e-12 11.95454211652757 -0.12923759232528653 IDEK(ub)NFVVVMVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDEKNFVVVMVTK 13 1 P54727;Q5W0S5;Q5W0S4;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 1 25041200.0 10412000.0 10262000.0 4367200.0 True False 13650232.829951432 8730949.600962693 3915324.0371404774 1.0 0.6396190973244928 0.2868320332638904 23.702422223397072 -7.462469191770535 0.29568753000346937 1.089237775331083 1.639347664560392e-12 0.9997542774124345 0.0045640101523411565 0.12163478701120391 0.028680887597372428 0.021066695018835745 0.062204606051166365 3.4477106327185156e-08 7.462469191770535 -1.0892377753294435 down IDEK(ub)NFVVVMVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDEKNFVVVMVTK 13 1 P54727;Q5W0S5;Q5W0S4;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 1 56187000.0 21587000.0 19287000.0 15313000.0 True False 20901732.50112638 26988399.680376295 11302065.919847012 1.0 1.2912039554100079 0.54072388110593 24.317119193464706 -6.801493540586406 1.4499014026795938 1.160364878093612 0.5299884919763896 0.8364776133277114 0.12492589463583646 0.2186271241835851 0.907218954806655 0.06777976688159523 0.15748284478534347 1.5794520993068724e-07 6.801493540586406 -0.6303763861172224 IDEK(ub)NFVVVMVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDEKNFVVVMVTK 13 1 P54727;Q5W0S5;Q5W0S4;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 1 71415000.0 24740000.0 33388000.0 13287000.0 True False 37532388.73627062 27429650.538365316 10660818.626101017 1.0 0.7308261334258696 0.28404316871520074 25.161632777199618 -7.027045777421433 0.39654338574547404 1.0266057950376999 4.138472404241351e-15 0.9998674636425806 0.0033992838823426424 0.07323018480574217 0.017471274521509574 0.0058064915338912 0.035088316625881466 9.396242629260004e-08 7.027045777421433 -1.0266057950376957 down IDEK(ub)NFVVVMVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDEKNFVVVMVTK 13 1 P54727;Q5W0S5;Q5W0S4;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 1 25130600.0 10412000.0 10289000.0 4429600.0 True False 14261597.773720125 9834397.958826972 3383419.7104756394 1.0 0.6895719620524453 0.23723987761807963 23.765632284919963 -7.230516697375207 0.4051408947443058 1.0286379693281922 1.0031515594700966e-10 0.9996085683021175 0.006196280152833236 0.09268107514602157 0.027949491990753715 0.009824101346923369 0.046709449903343116 5.881435012803102e-08 7.230516697375207 -1.028637969227877 down IDEK(ub)NFVVVMVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IDEKNFVVVMVTK 13 1 P54727;Q5W0S5;Q5W0S4;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 1 56734900.0 25171800.0 23412200.0 8150900.0 True False 20931466.999815684 23286073.831642162 9855215.504496502 1.0 1.1124912473572546 0.4708325271507861 24.31917009186781 -6.861654064266754 1.1774383717739307 1.0613154176458754 0.4387773065067334 0.9556145373068367 0.05893975171000636 0.14510230731148388 0.38132822646825915 0.0390173568760546 0.09124896626895804 1.37513689930819e-07 6.861654064266754 -0.622538111139142 down IDEK(ub)NFVVVMVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDEKNFVVVMVTK 13 1 P54727;Q5W0S5;Q5W0S4;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 1 61652000.0 24740000.0 36912000.0 0.0 True False 32026417.6983079 34857814.7517442 0.0 1.0 1.0884081722816565 0.0 24.932759099292067 -6.966401524426967 1.175668731982114 1.05418611182387 1.1230775778571147e-20 0.9766433406468469 0.07543081382629535 0.10139003234949347 0.2772545048118456 0.05362440454312116 0.10059439474772235 1.0804345799065108e-07 6.966401524426967 -1.05418611182387 down IDELQVVK(ub)TGGTPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDELQVVKTGGTPK 14 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 10816600.0 2622800.0 2942600.0 5251200.0 True False 3438516.199231327 2503575.5501649594 4707856.197067254 1.0 0.7280976459336235 1.3691534151037839 21.713354711629623 -6.791507720346712 1.490707440799222 0.8483302715445051 1.3762182309771802 0.8060450005564453 0.11569914441388714 0.23311628140632495 1.0234155179653257 0.06109087185938823 0.14284824300881482 1.6161894952461445e-07 6.791507720346712 0.5278879594326751 IDELQVVK(ub)TGGTPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDELQVVKTGGTPK 14 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 14432800.0 3749100.0 3328500.0 7355200.0 True False 3630086.8726535826 4657587.4078982 5428652.468729757 1.0 1.2830512247475547 1.49546075870119 21.791572643508516 -6.9742912818921505 0.11661137022687963 0.5974310697277158 2.1865258090707913 0.9999995105752147 0.00014186776752468224 0.07493318356584602 0.0034635210942597122 0.015569736809873216 0.031222992202151738 1.0609837153062875e-07 6.9742912818921505 1.5890947393430754 IDELQVVK(ub)TGGTPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDELQVVKTGGTPK 14 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 11431500.0 2622800.0 3970700.0 4838000.0 True False 3592520.0385049083 3795261.344651013 3695364.04173766 1.0 1.0564342867884124 1.028627259453103 21.776564773152515 -10.20309420036015 4.651101024086626 0.9999916398534296 1.0425307731210451 0.7572313790970716 0.011352171373505825 9.843156474965006e-07 1.6865857254438112e-07 0.010993853238220372 0.0036638975559343473 6.264779641416688e-11 10.20309420036015 0.04253913326761549 IDELQVVK(ub)TGGTPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDELQVVKTGGTPK 14 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 13605600.0 3749100.0 4629000.0 5227500.0 True False 3117542.7632910176 4604062.658215437 6320546.080770897 1.0 1.4768242195193444 2.027412792919846 21.571977918942792 -6.969240237654429 0.2757283770035221 0.8722919649674523 2.6486254687985924 0.9999758354693762 0.002063619463345556 0.07655000391188058 0.009909216836225823 0.010426914154271268 0.05081545560521685 1.073395480437734e-07 6.969240237654429 1.77633350383114 IDEMPEAAVK(ub)STANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDEMPEAAVKSTANK 15 1 P51858 P51858 HDGF Hepatoma-derived growth factor 1 5933100.0 2450800.0 2339500.0 1142800.0 True False 3213022.53358096 1990455.7192995767 1024554.0185116659 1.0 0.619496346040619 0.3188754538144448 21.615499668082926 -7.762062757832353 0.2363320848648714 1.1711357038782975 2.844041192482505e-10 0.9997957240505725 0.003983386035786899 0.12575664564572697 0.03321973464453242 0.047597211490604335 0.08450625260928109 1.729566409730908e-08 7.762062757832353 -1.1711357035938934 down IDEMPEAAVK(ub)STANK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDEMPEAAVKSTANK 15 1 P51858 P51858 HDGF Hepatoma-derived growth factor 1 19233900.0 5234600.0 6745900.0 7253400.0 True False 7941270.9005207 5542041.439042737 5819762.310721836 1.0 0.697878401135938 0.732850243194731 22.920938480364295 -10.00819795321129 7.1856112465858315 1.0000000212610813 0.7153643223351498 0.988804841079668 0.01427719473487492 4.857410611005776e-09 6.880123319906236e-10 0.013823835389636741 0.004607944786560831 9.813005602364091e-11 10.00819795321129 -0.28463569892593155 IDEMPEAAVK(ub)STANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDEMPEAAVKSTANK 15 1 P51858 P51858 HDGF Hepatoma-derived growth factor 1 7642500.0 2450800.0 3068500.0 2123200.0 True False 3356926.9903796837 2932923.5238274434 1621743.8886765984 1.0 0.8736929734345269 0.48310371161607296 21.678709729605817 -6.950767113590634 0.550360422649189 1.0053902281602038 0.3330458930938719 0.9992600968448726 0.005984906574003673 0.08317922133692479 0.0346992228618923 0.006492870500618045 0.032404874863881605 1.1200383326831503e-07 6.950767113590634 -0.672344335066332 down IDEPLEGSEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDEPLEGSEDR 11 0 P61978;P61978-2;S4R359;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 34069400.0 8931900.0 3421500.0 21716000.0 False True 8648361.723574884 4787722.792886784 16027928.133964464 1.0 0.5535988139621585 1.8532906747266769 23.043995435353953 -6.813991176644959 1.397761067284945 0.7578390248938914 1.8781497412640997 0.8699794265626345 0.19442478188643272 0.20140644088575657 0.7747605554281309 0.10935118739649083 0.25251740591243343 1.5346481612015175e-07 6.813991176644959 1.1203107163702084 IDESIHLQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDESIHLQLR 10 0 B0QY89;Q9Y262;Q9Y262-2;B0QY90 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 2761200.0 0.0 0.0 2761200.0 False True 0.0 0.0 2215447.609723045 0.0 IDESIHLQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDESIHLQLR 10 0 B0QY89;Q9Y262;Q9Y262-2;B0QY90 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 2504830.0 402850.0 717580.0 1384400.0 False True 551794.5316119053 685874.942880266 1057433.2326129833 1.0 1.2429897427157972 1.9163532293877639 19.073771633818325 -6.953219693240135 0.5223037083192069 0.9887581113304917 2.200753191923571 0.9994303242041676 0.009251400722482862 0.08221809273975184 0.030806978664260565 0.010442634396304638 0.055633235107584354 1.1137309964553415e-07 6.953219693240135 1.2119950805930793 IDFFDYSK(ub)LTPLDQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDFFDYSKLTPLDQR 15 1 Q9NWF9;Q9NWF9-1 Q9NWF9 RNF216 E3 ubiquitin-protein ligase RNF216 1 21090000.0 2036100.0 2197900.0 16856000.0 True False 1971465.1200047932 3075532.9318970847 12440907.93083924 1.0 1.5600240149770477 6.310488481180429 20.9108367552245 -6.929022484454185 0.7547715137959887 0.925077696824809 7.261897037942437 0.9963426081349485 0.14407801122674224 0.09314872709408896 0.08018989136413587 0.13050647019644163 0.432169264372837 1.1775450076479612e-07 6.929022484454185 6.336819341117628 up IDFFDYSK(ub)LTPLDQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDFFDYSKLTPLDQR 15 1 Q9NWF9;Q9NWF9-1 Q9NWF9 RNF216 E3 ubiquitin-protein ligase RNF216 1 99400800.0 3162800.0 23075000.0 73163000.0 True False 4798198.831652244 18957085.96420209 58702300.98151792 1.0 3.9508754491681377 12.234236854520674 22.19406151176068 -6.95293473447748 0.5256403230358287 0.8651329696353661 15.693216754592548 0.9994119134795026 0.11532232280723927 0.08232829987861565 0.03124786588072329 0.12950286854048754 0.6846235398848454 1.1144620017102931e-07 6.95293473447748 14.828083784957181 IDFFDYSK(ub)LTPLDQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDFFDYSKLTPLDQR 15 1 Q9NWF9;Q9NWF9-1 Q9NWF9 RNF216 E3 ubiquitin-protein ligase RNF216 1 17360000.0 2036100.0 2993900.0 12330000.0 True False 1693107.3645239791 2977771.266457376 14908145.992521299 1.0 1.758761038343592 8.805198243711354 20.691242030658778 -6.927432289080998 0.7675789929247286 0.8820238889991816 10.161526977084181 0.9960090503475822 0.22200863909103546 0.09399311717021187 0.0843745570913157 0.19925316632500645 0.6468162061827845 1.181864562865662e-07 6.927432289080998 9.279503088084999 up IDFFDYSK(ub)LTPLDQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDFFDYSKLTPLDQR 15 1 Q9NWF9;Q9NWF9-1 Q9NWF9 RNF216 E3 ubiquitin-protein ligase RNF216 1 90550800.0 3162800.0 20515000.0 66873000.0 True False 4094306.948108651 19373322.215865653 54702800.174924225 1.0 4.731770837263455 13.36069837172173 21.96518783385313 -6.9571123329338365 0.4743901763115589 0.7815431614619511 17.667292080466854 0.9996476254956023 0.09717260762240451 0.08074936957046329 0.025069389055358302 0.12031545198536758 0.7119934629228184 1.1037930801191035e-07 6.9571123329338365 16.885748919004904 IDFGTHISGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDFGTHISGR 10 0 P50579;F8VQZ7;P50579-3;G3V1U3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 0 17215400.0 4900300.0 5439500.0 6875600.0 False True 6424340.754572703 4627947.803004926 6164178.867412324 1.0 0.7203770752214312 0.9595037223118651 22.615116986446886 -10.12510818561623 6.752847688474893 1.0000001978200568 0.8399403990991179 0.3739724951321317 0.09762304487902539 2.9074066494809027e-07 3.7648651134020054e-08 0.09452322295643428 0.03150770225187702 7.49707429010271e-11 10.12510818561623 -0.1600597987209389 IDFGTHISGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDFGTHISGR 10 0 P50579;F8VQZ7;P50579-3;G3V1U3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 0 11675700.0 2317100.0 1441400.0 7917200.0 False True 2243544.9288164168 2016958.5368016989 5843447.809091148 1.0 0.899005190801214 2.6045601913458722 21.09734864477218 -6.89283566704985 1.0054356969105513 0.9144908584162458 2.759682395237278 0.982652805629978 0.10290277124990915 0.11687336235819498 0.2086393979855857 0.07767652704241673 0.19573824394704561 1.2798655016206086e-07 6.89283566704985 1.8451915368210323 up IDFGTHISGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDFGTHISGR 10 0 P50579;F8VQZ7;P50579-3;G3V1U3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 0 22018000.0 3796700.0 12958000.0 5263300.0 False True 5759871.475949817 10645543.658683887 4223006.448013661 1.0 1.8482259028060013 0.7331772012008787 22.457605189485072 -6.703315470795666 1.8190121059808224 1.5249752243708354 0.7362695028565371 0.43344242058953186 0.35783092303033653 0.38861168779471783 2.502081459918516 0.15680183282582813 0.40161584003542733 1.9800881704946766e-07 6.703315470795666 -0.7887057215142983 IDFGTHISGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDFGTHISGR 10 0 P50579;F8VQZ7;P50579-3;G3V1U3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 0 11152700.0 4900300.0 2115100.0 4137300.0 False True 6712073.33562819 2021647.8882996333 3160154.950368168 1.0 0.3011957389631866 0.4708165111358107 22.678327047969777 -10.536313783602852 9.51792406607725 1.0000237046660112 0.38600612505487236 0.9458600154364657 0.06924739026663418 3.4833607946295895e-05 1.6969773762288267e-06 0.0670510678918777 0.022349499105916645 2.9086148453618758e-11 10.536313783602852 -0.6140175796111389 IDFGTHISGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDFGTHISGR 10 0 P50579;F8VQZ7;P50579-3;G3V1U3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 0 5794100.0 2317100.0 2185400.0 1291600.0 False True 1926771.314934685 2173626.8164320635 1561667.5883163435 1.0 1.1281187339587038 0.8105100881519414 20.877753920206455 -6.7971930701993895 1.4672123502188845 1.070941285725553 0.8064166114538787 0.8238811403238475 0.05475269671637296 0.22477964661223754 0.9555541781447091 0.029360987318804346 0.06840692264419031 1.5951698399812306e-07 6.7971930701993895 -0.26452467427167425 IDFGTHISGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDFGTHISGR 10 0 P50579;F8VQZ7;P50579-3;G3V1U3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 0 14238400.0 3796700.0 7527000.0 2914700.0 False True 4914902.994145733 7108115.83323524 2384254.5073475325 1.0 1.44623725874181 0.48510713440071535 22.22873151157752 -6.780453790598655 1.5339926628937368 1.252526191729484 0.4773729698568249 0.7690029112296826 0.188746470320175 0.24988483981940907 1.1614499249196106 0.09690537832684504 0.22857993302581045 1.6578537248894204e-07 6.780453790598655 -0.7751532218726591 down IDFSK(ub)LTSLNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDFSKLTSLNVK 12 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 1 27212700.0 6868600.0 9879100.0 10465000.0 True False 9004801.115617013 8405176.788430192 9382182.187368372 1.0 0.9334105973593472 1.041908873600425 23.102262981748712 -6.7406079394075755 1.6842271998035871 0.9604087301874676 1.0419842656169223 0.6078052897490309 0.027977668718921374 0.31670102094510194 1.7641257037629472 0.0131395352348562 0.03222478176269291 1.817155364770011e-07 6.7406079394075755 0.08157553542945462 IDFSK(ub)LTSLNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDFSKLTSLNVK 12 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 1 37718000.0 13122000.0 13716000.0 10880000.0 True False 12705449.292619662 19192870.3279951 8030201.606996386 1.0 1.5106014660295286 0.6320281496586639 23.59894405737324 -6.749175107284983 1.6531866199640046 1.300538642397487 0.6304212959782373 0.6453116065769312 0.21454835145888318 0.3014782046471404 1.6209127308851978 0.10253724468148104 0.24912047356990474 1.781660258216557e-07 6.749175107284983 -0.6701173464192497 IDFSK(ub)LTSLNVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDFSKLTSLNVK 12 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 1 73004000.0 11960000.0 18874000.0 42170000.0 True False 18144194.393120285 15505787.236764943 33835081.01623241 1.0 0.8545867014434245 1.8647882779001541 24.11300466642135 -6.8703839569427485 1.132124037291107 0.9175728658082543 1.9243682561749775 0.9650617651603484 0.08334823593935756 0.1364840321656353 0.32672365928748226 0.05712445851215339 0.1353292755379043 1.3477708002650534e-07 6.8703839569427485 1.0067953903667233 IDFSK(ub)LTSLNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDFSKLTSLNVK 12 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 1 22244600.0 6868600.0 6113700.0 9262300.0 True False 9408107.03693565 5843576.5186976725 7074735.503056361 1.0 0.6211213898562326 0.7519828882985052 23.165473043271604 -10.397904209275897 5.13302517410978 1.0002544441435925 0.6865521390773508 0.8843893296048109 0.05342398302666025 0.0001556869400463558 1.8261875446443382e-05 0.051769066774733294 0.01724251637918453 4.000329738213734e-11 10.397904209275897 -0.31370230506624175 IDFSK(ub)LTSLNVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDFSKLTSLNVK 12 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 1 37288500.0 13122000.0 15810000.0 8356500.0 True False 10911524.403164703 15724828.39196071 10103805.513909502 1.0 1.441121131287576 0.92597561445943 23.379349332807518 -6.680006108392059 1.9015272768785527 1.2791093536865326 0.9279255608791978 0.3241180286108919 0.1869593252120212 0.4386184835720545 3.066210906378713 0.07888643818810402 0.20808188110066947 2.0892667449173612e-07 6.680006108392059 -0.3511837928073348 IDFSK(ub)LTSLNVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDFSKLTSLNVK 12 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 1 73914000.0 11960000.0 16793000.0 45161000.0 True False 15482455.766845668 15858454.787766606 36942161.39099113 1.0 1.0242854897558376 2.386066005762442 23.8841309885138 -6.910765454391446 0.8904852223825384 0.9588500317552444 2.5649778436853037 0.9912076688924731 0.060737807839392935 0.10391466696627183 0.1360302057577564 0.0499157460447922 0.13853560666009457 1.2281023025228245e-07 6.910765454391446 1.6061278119300593 up IDFYFDENPYFENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDFYFDENPYFENK 14 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 17633200.0 4767600.0 7172700.0 5692900.0 False True 6250369.769504075 6102561.118965615 5103853.318152828 1.0 0.976352015002436 0.8165682201803214 22.575510110914852 -6.933379953786707 0.7185401250777019 1.0021517428746398 0.7807551728417516 0.9971612653407642 0.004340738060799647 0.09092105750993697 0.06936687491463792 0.004037295985135306 0.01419864077630162 1.1657892498300355e-07 6.933379953786707 -0.22139657003288826 IDFYFDENPYFENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDFYFDENPYFENK 14 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 90496000.0 39368000.0 13461000.0 37667000.0 False True 38118284.38895367 18836047.498187676 27800882.714221742 1.0 0.4941473048993304 0.7293319507915257 25.18397985273413 -10.374009228516595 5.944568690675784 1.0000737696844344 0.6117396278454287 0.7841967033383251 0.09601372962883893 9.388927132987249e-05 9.886705099961916e-06 0.09298246134442094 0.030988297988312725 4.2265963288766486e-11 10.374009228516595 -0.3883341418390057 IDFYFDENPYFENK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDFYFDENPYFENK 14 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 311812000.0 16303000.0 268310000.0 27199000.0 False True 24732842.908949874 220427984.18440175 21823105.728254832 1.0 8.91235936749662 0.8823533068395417 24.559924743604356 -6.649562164826512 2.010102355188091 6.136161531817633 0.9161174680783234 0.1922523821748222 3.3774569555542224 0.5096207066754509 3.94639229859747 1.362923914568882 3.7408723803469357 2.240979249495588e-07 6.649562164826512 -5.2200440637393095 IDFYFDENPYFENK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDFYFDENPYFENK 14 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 16733300.0 4767600.0 4603700.0 7362000.0 False True 6530310.559545529 4400293.311599936 5623247.225149359 1.0 0.6738260411165148 0.8610995103333497 22.638720172437743 -10.19310439429983 5.272825608895595 1.000012938150408 0.7674627768869136 0.672748549938919 0.07645407365726892 1.1629003906114278e-05 1.7795538557410675e-06 0.07403045516826279 0.024675446168655784 6.410554632289467e-11 10.19310439429983 -0.23255016126349437 IDFYFDENPYFENK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDFYFDENPYFENK 14 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 66820000.0 39368000.0 12452000.0 15000000.0 False True 32736236.29810908 12384918.60447151 18136430.647836145 1.0 0.37832445036410284 0.5540169762546511 24.964385128168406 -10.84767566850152 10.993001175811276 1.0112953798654394 0.46617071330969745 0.9248651438469238 0.0717261733420943 0.018744294143989378 0.00025972942455038 0.06555947017160974 0.023149522903426478 1.4201176708968687e-11 10.84767566850152 -0.5451246665557419 IDFYFDENPYFENK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDFYFDENPYFENK 14 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 81887000.0 16303000.0 35638000.0 29946000.0 False True 21104554.88017436 33654713.97168027 24496135.27190762 1.0 1.5946658985589666 1.160703715903495 24.331051065696805 -10.370814891535396 5.195618015295543 0.9997967062482692 1.377684807231252 0.5024718031654125 0.17716431919513717 0.0004174172335500719 5.054886814547813e-05 0.1716299205646835 0.057179538148734436 4.2577985375521325e-11 10.370814891535396 0.37788810098298276 IDFYFDENPYFENK(ub)VLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDFYFDENPYFENKVLSK 18 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 84466000.0 42174000.0 18373000.0 23919000.0 True False 40835209.4548805 25709434.713929288 17653896.345381096 1.0 0.6295898822886183 0.43232045533860136 25.28331029190944 -11.196101817357478 0.10945526718433049 2.050156524243489 9.649790204617608e-19 0.99984987334357 0.0028832787099683068 3.6953650246009384 0.06832917030482706 1.249827821976864 0.29074588231546333 6.3664624607203235e-12 11.196101817357478 -2.050156524243489 IDFYFDENPYFENK(ub)VLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDFYFDENPYFENKVLSK 18 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 211616000.0 58685000.0 75738000.0 77193000.0 True False 89029435.44818258 62221962.15630505 61935769.71510621 1.0 0.6988920219820987 0.6956774397514227 26.407779071684967 IDFYFDENPYFENK(ub)VLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDFYFDENPYFENKVLSK 18 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 7383000.0 2202500.0 2950700.0 2229800.0 True False 3016823.770324485 2820328.317339946 1703167.1641725148 1.0 0.9348667777954415 0.564556398993543 21.524598992323625 -6.936985762326204 0.6870377163397403 1.0044522068386053 0.47297090071888315 0.9977417566829317 0.009113118731377932 0.08916925751542065 0.06107702125556853 0.008680027457391118 0.032317851431864254 1.156150144167552e-07 6.936985762326204 -0.5314813061197221 IDFYFDENPYFENK(ub)VLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDFYFDENPYFENKVLSK 18 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 222301000.0 58685000.0 96686000.0 66930000.0 True False 75968889.35429245 91305339.1061753 54749426.75979363 1.0 1.2018780303652854 0.7206822059022262 26.178905393777416 -6.792740702845032 1.4853738877997145 1.1124280495064707 0.7151713839746119 0.8100856402958321 0.08597886708328221 0.23128623454842448 1.0080213704472214 0.04555446726866132 0.10644479881096264 1.6116075643498568e-07 6.792740702845032 -0.3972566655318588 IDGITIQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDGITIQAR 9 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 14943700.0 3163000.0 4369300.0 7411400.0 False True 4146723.630535568 3717417.4713980085 6644539.423168849 1.0 0.8964709979762715 1.602358877799309 21.983540467510352 -6.869624675329561 1.1360226792814865 0.9415734672370542 1.6434153748322737 0.9643100988241745 0.05879871855050484 0.13721821847332566 0.3312010216540096 0.0401763156659831 0.09506164008665859 1.3501291831310497e-07 6.869624675329561 0.7018419075952196 IDGITIQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDGITIQAR 9 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 10874500.0 2351900.0 2174700.0 6347900.0 False True 2277240.2218649713 3043069.05091068 4685194.557082021 1.0 1.3362969008243342 2.0574002303740393 21.118855056061474 -6.958660650164649 0.4539221855248158 0.9776558402499106 2.444815653810638 0.9997172341995499 0.007417500020540994 0.08018316998805797 0.02292626745542714 0.009696363953725046 0.05961416772715109 1.0998649182634859e-07 6.958660650164649 1.4671598135607273 up IDGITIQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDGITIQAR 9 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 13782700.0 3163000.0 4820200.0 5799500.0 False True 4332446.576860998 4607227.62573017 4429777.544451749 1.0 1.0634239901160558 1.022465589791824 22.046750529033243 -10.389507272518186 5.752892252915591 0.9999867930018337 1.0429447899539326 0.594451527716122 0.016721196912502442 2.8333391077145122e-06 3.0069815139372e-07 0.016195208184994637 0.005396743097564698 4.0784273214610936e-11 10.389507272518186 0.0429579969520989 IDGITIQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDGITIQAR 9 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 6065000.0 2351900.0 1872200.0 1840900.0 False True 1955709.0568360798 1862114.0869973965 2225823.6786401053 1.0 0.9521426924360109 1.1381159538326284 20.89926033149575 -6.8384055988687775 1.2896581267209561 0.9745319807914429 1.1440465601349494 0.9216917271365148 0.022064387964572763 0.17067425877562759 0.5520865663022397 0.013418346342052639 0.030903395176043354 1.4507560860069012e-07 6.8384055988687775 0.16951457934350656 IDGQQTIIACIESHQFQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDGQQTIIACIESHQFQAK 19 0 P47755;F8W9N7;A0A0D9SET8 P47755 CAPZA2 F-actin-capping protein subunit alpha-2 0 6391800.0 3416800.0 0.0 2975000.0 False True 4479457.888338271 0.0 2667175.538215091 1.0 0.0 0.5954237331170724 22.09489271474774 -10.069979451345183 6.550712224560824 1.000000567830025 0.2977118665585342 0.6497232592573507 0.24308072114666415 2.016018128678402e-06 2.864324643594107e-07 0.23536208907282222 0.07845396539875878 8.511783107737477e-11 10.069979451345183 -0.7022887012714908 IDGVFAACQSGSFDK(ub)LEAVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDGVFAACQSGSFDKLEAVVK 21 1 P35249;H7C1P0 P35249 RFC4 Replication factor C subunit 4 1 16426800.0 7858600.0 2308300.0 6259900.0 True False 7609133.0445801625 3230016.2276254757 4620244.397025431 1.0 0.42449201619968435 0.6071972154983334 22.859300657279654 -10.545847208315504 7.543501563655101 1.0001815860458367 0.5158446158490119 0.9035011261311408 0.07458908527253286 0.0002278721056346339 1.3718959672534434e-05 0.07224693756740087 0.024073523755780372 2.8454620100209756e-11 10.545847208315504 -0.48433697019682487 IDHLVK(ub)PR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDHLVKPR 8 1 A0A0A0MR42;K7ENP4;Q8TEP8-1;Q8TEP8 A0A0A0MR42 CEP192 Centrosomal protein of 192 kDa 1 1617940.0 439510.0 487010.0 691420.0 True False 425557.99562561046 681475.6327235985 510316.3598446171 1.0 1.6013695894064097 1.1991699488442318 18.698996232199686 -10.113824513922843 4.775628632170483 0.9999765411207109 1.4002697691291406 0.5690711288714347 0.1641973156978253 114451964.73113623 0.1420226130180347 29524.15933354811 0.05620910855395646 7.694412868715888e-11 10.113824513922843 0.4002932280084297 IDHLVK(ub)PR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDHLVKPR 8 1 A0A0A0MR42;K7ENP4;Q8TEP8-1;Q8TEP8 A0A0A0MR42 CEP192 Centrosomal protein of 192 kDa 1 1620660.0 439510.0 719040.0 462110.0 True False 365472.0385943387 715166.388801734 558735.06444477 1.0 1.9568292872756372 1.5288038630636434 18.479401507633963 -10.212804676696324 4.916003118770915 0.9998997632627931 1.7428165751708016 0.8006265910017567 0.1747406477136315 0.00019199632811293835 3.07444388739317e-05 0.16921451351015857 0.05639730154112639 6.12625857352166e-11 10.212804676696324 0.7429168119080085 IDIDPEETVK(ub)ALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDIDPEETVKALK 13 1 P54727;Q5W0S5 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 22353100.0 5296400.0 12337000.0 4719700.0 True False 6943631.690410557 10496367.68924936 4231350.718559241 1.0 1.5116538660518641 0.6093858239057972 22.727258994567638 -6.752867281638531 1.6392526787360566 1.2998150349214495 0.6071941216142674 0.6612250857122339 0.21503754820969032 0.295061905277744 1.5608220073443695 0.10359026869847102 0.25073485944351553 1.76657759605253e-07 6.752867281638531 -0.692620913307182 IDIDPEETVK(ub)ALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDIDPEETVKALK 13 1 P54727;Q5W0S5 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 41285600.0 23287000.0 10670000.0 7328600.0 True False 22547766.931659345 14930586.643314924 5409019.806712656 1.0 0.6621758459970096 0.23989159649853598 24.426481224248878 -7.335036468095587 0.3739332062723198 1.0414801701562648 4.5247050159480003e-10 0.9995563051495411 0.006549886685419552 0.10677237503661315 0.03143298952723715 0.013090810324561023 0.0540570188927713 4.623421964819674e-08 7.335036468095587 -1.0414801697037943 down IDIDPEETVK(ub)ALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDIDPEETVKALK 13 1 P54727;Q5W0S5 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 114961000.0 24664000.0 90297000.0 0.0 True False 37417091.17992632 74182794.85631889 0.0 1.0 1.9825911773739586 0.0 25.157194071443058 -6.778255408350944 1.584072961184576 1.561850915610926 7.850158404666195e-12 0.7376852623356738 0.41454766235284646 0.25885229212867067 1.2894449326684772 0.20753275423994771 0.4821798059790758 1.6662669936245212e-07 6.778255408350944 -1.5618509156030758 IDIDPEETVK(ub)ALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDIDPEETVKALK 13 1 P54727;Q5W0S5 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 25958700.0 5296400.0 13232000.0 7430300.0 True False 7254622.209828201 12647366.4876274 5675416.1718320185 1.0 1.7433528751494982 0.7823172603176011 22.79046905609053 -6.700179594107997 1.829938511150542 1.4615232087406858 0.785146449051759 0.4184167620224316 0.3137710419059444 0.395227811558701 2.57311170512895 0.13677509373815985 0.3517094548345263 1.9944373832944843e-07 6.700179594107997 -0.6763767596889267 IDIDPEETVK(ub)ALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDIDPEETVKALK 13 1 P54727;Q5W0S5 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 39179500.0 23287000.0 12164000.0 3728500.0 True False 19364172.28901816 12098470.11763503 4508112.111363805 1.0 0.6247863289512422 0.2328068581542446 24.206886499683154 -7.520743993780284 0.3447588284234748 1.0619687715265536 8.49363010691028e-15 0.9994120380388062 0.007595181233794618 0.12233409579314773 0.039519078780740555 0.02147147230726182 0.06682532032841695 3.01478264282797e-08 7.520743993780284 -1.0619687715265451 down IDIDYQK(ub)LHDAFFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDIDYQKLHDAFFK 14 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 14332400.0 3132400.0 9402700.0 1797300.0 True False 4106606.7342047547 7999853.811437531 1611332.6369189837 1.0 1.9480447798434501 0.3923756865973724 21.96951536475943 -6.741729696310507 1.6800720911451792 1.5629315709999556 0.3910590741858834 0.6128351283439297 0.3983164216482271 0.3146811824436361 1.7446454335496884 0.18749542562983526 0.459278104480435 1.812467816614581e-07 6.741729696310507 -1.1718724968140721 IDIDYQK(ub)LHDAFFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDIDYQKLHDAFFK 14 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 58873500.0 17856400.0 21853300.0 19163800.0 True False 17289558.3560992 30579436.65345398 14144225.878323277 1.0 1.7686649955790537 0.8180790733346668 24.04339768150849 -6.691570230202049 1.8607928546819366 1.4812052594542402 0.8213059015844896 0.3777173155494393 0.3249907410408247 0.4133534201297276 2.776151948466386 0.13965386967970517 0.36295603952043026 2.0343691893400644e-07 6.691570230202049 -0.6598993578697506 IDIDYQK(ub)LHDAFFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDIDYQKLHDAFFK 14 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 70097300.0 24098100.0 13720200.0 32279000.0 True False 36558579.50709467 11271723.113588108 25899041.50161171 1.0 0.3083195043560345 0.7084258155212422 25.123706679413772 -10.78656492533754 6.9437094088901254 1.01620335288777 0.5083726599394066 0.6681131555702853 0.16334271753699844 0.039661410032487854 0.0012191072072772035 0.15309306172333514 0.05271863539542144 1.6346887532451898e-11 10.78656492533754 -0.5078306929483635 IDIDYQK(ub)LHDAFFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDIDYQKLHDAFFK 14 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 18715600.0 3132400.0 6648500.0 8934700.0 True False 4290532.9299270995 6354747.2863505725 6824507.875922576 1.0 1.4811090813510075 1.5905967830524332 22.032725426282322 -11.777401551955458 0.2502992266203805 1.742536283976321e-09 1.639672109225281 0.9993482832836128 0.006548826711358346 4.609740472967801 0.14341316819443006 2.4792164068527356 0.0502931659145425 1.669546225404338e-12 11.777401551955458 1.6396721074827447 IDIDYQK(ub)LHDAFFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDIDYQKLHDAFFK 14 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 49898300.0 17856400.0 22550000.0 9491900.0 True False 14848387.772646712 22428518.67417548 11476612.40441304 1.0 1.510501949275104 0.7729197661146039 23.823802956942767 -6.720544788834464 1.7576798870109995 1.310404323323664 0.7740584007602385 0.5149814447198999 0.21480621359756036 0.3542393860983951 2.139177003049723 0.09703260024160416 0.24340228778303286 1.903071963448852e-07 6.720544788834464 -0.5363459225634255 IDIDYQK(ub)LHDAFFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDIDYQKLHDAFFK 14 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 59304900.0 24098100.0 12749900.0 22456900.0 True False 31195465.494567208 12040356.856937138 18369974.6272525 1.0 0.3859649684994765 0.5888668220210304 24.89483300150622 -10.204443928229443 5.358035938607804 1.0000279992791774 0.4874158952601614 0.8948404687125904 0.08283433483244652 2.7706960742546535e-05 4.1139041100481415e-06 0.08020837212706654 0.026734666608306177 6.245339786717878e-11 10.204443928229443 -0.512612104019016 IDIGAVYSHRPNQHNTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDIGAVYSHRPNQHNTVK 18 1 A0A5F9ZHB6;P49642;F8VNY2;F8VSB2 A0A5F9ZHB6 PRIM1 DNA primase small subunit;DNA primase 0 15881000.0 5358500.0 3926100.0 6596400.0 False True 7025045.391787824 3340341.1838179347 5913867.8051368045 1.0 0.4754903345852747 0.8418262766031419 22.744076116550353 -10.040396521879588 6.150038956011329 1.0000004281446948 0.6586583055942021 0.5365219682978055 0.14955602206430255 8.779139245859504e-07 1.3718594959839558e-07 0.14480717694426984 0.04826899856500027 9.111785303402304e-11 10.040396521879588 -0.3413421225504927 IDIGAVYSHRPNQHNTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDIGAVYSHRPNQHNTVK 18 1 A0A5F9ZHB6;P49642;F8VNY2;F8VSB2 A0A5F9ZHB6 PRIM1 DNA primase small subunit;DNA primase 0 11378400.0 3219700.0 1462700.0 6696000.0 False True 3117492.385874677 2046763.7378797329 4942116.724305865 1.0 0.65654169586864 1.5852859005200914 21.571954605762677 -6.806575152345031 1.4287708220675044 0.8120440634371835 1.6003081896101639 0.8507198612846703 0.14814066425740854 0.21151074045715446 0.8515897294763451 0.08154026250789502 0.18893842986914405 1.5610788782171262e-07 6.806575152345031 0.7882641261729804 IDIGAVYSHRPNQHNTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDIGAVYSHRPNQHNTVK 18 1 A0A5F9ZHB6;P49642;F8VNY2;F8VSB2 A0A5F9ZHB6 PRIM1 DNA primase small subunit;DNA primase 0 12326400.0 5358500.0 3396500.0 3571400.0 False True 7339682.258017612 3246431.3992764917 2727908.8752918304 1.0 0.4423122534671312 0.37166579960759993 22.807286178073245 -13.999999999999998 0.2913252086170417 5.841648271413716 0.35267016249059135 0.9996304285633496 0.005402622049212367 16.04501261605851 0.17119315192855317 46.59332367737122 0.026522730938348234 1.0000000000000041e-14 13.999999999999998 -5.488978108923124 IDIGAVYSHRPNQHNTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDIGAVYSHRPNQHNTVK 18 1 A0A5F9ZHB6;P49642;F8VNY2;F8VSB2 A0A5F9ZHB6 PRIM1 DNA primase small subunit;DNA primase 0 7820200.0 3219700.0 2957300.0 1643200.0 False True 2677323.206894481 2941368.43792191 1986785.5227016204 1.0 1.0986228447680413 0.7420790727041734 21.352359881196953 -6.832929681170716 1.3147806741951416 1.052599493706344 0.7318983461864667 0.9116079128410584 0.04469225051474275 0.1772217061656054 0.5981068481157397 0.02668096810928001 0.06140055652364867 1.4691641382275622e-07 6.832929681170716 -0.32070114751987744 IDIIPNPQER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDIIPNPQER 10 0 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 94828700.0 2480700.0 49097000.0 43251000.0 False True 3252221.723132976 41771918.97860709 38775801.41288769 1.0 12.844117816901726 11.9228652637907 21.63299418711846 -10.273467235680982 6.249092352388728 0.9996718252617686 12.38349154034622 0.9951119052436462 0.37609977989307464 0.0017196083190551738 0.00019992762980152395 0.36415932178817606 0.12138568200317507 5.32761415730595e-11 10.273467235680982 11.383819715084451 IDIIPNPQER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDIIPNPQER 10 0 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 77277300.0 25439000.0 9162300.0 42676000.0 False True 24631452.8696046 12820854.170763306 31497875.34744278 1.0 0.5205074275819247 1.2787664420035652 24.553998390950376 -6.735825228325981 1.7020674763320256 0.7133279945750358 1.2788098069147247 0.5859951793486149 0.20149238153306268 0.3254351434555616 1.8495094086909651 0.09371673359797233 0.23102707962219027 1.837277564054875e-07 6.735825228325981 0.5654818123396889 IDIIPNPQER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDIIPNPQER 10 0 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 134557700.0 2480700.0 65979000.0 66098000.0 False True 3397881.828396806 63063829.616623975 50487013.7310408 1.0 18.559747749196696 14.858378331203372 21.69620424864135 -9.617877661576665 8.867037838879767 1.0000000016371258 16.70906180889777 0.960026799692456 1.5110777372713613 0.0 0.0 1.4630947278196325 0.48769824260654404 2.4105843817285747e-10 9.617877661576665 15.709061807260642 IDILDSALLRPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDILDSALLRPGR 13 1 P62195;P62195-2 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 0 7903800.0 0.0 4731100.0 3172700.0 False True 0.0 4025238.321683358 2844419.4386874 0.0 IDILDSALLRPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDILDSALLRPGR 13 1 P62195;P62195-2 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 0 11134100.0 4852000.0 1937800.0 4344300.0 False True 4697975.915850526 2711573.645493505 3206397.503793605 1.0 0.5771791286423824 0.6825061603605765 22.163607886724503 -9.955861627264895 6.845541896455047 1.0000000263447093 0.6298426445014841 0.9427513366723361 0.042999580638591994 1.7292356239789414e-08 2.6282108272441636e-09 0.04163416802876949 0.013878054975596566 1.106976427087131e-10 9.955861627264895 -0.3701573818432252 IDILDSALLRPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDILDSALLRPGR 13 1 P62195;P62195-2 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 0 7819800.0 0.0 4240100.0 3579700.0 False True 0.0 4052758.3618643377 2734248.5862356974 0.0 IDIQIK(ub)DAIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDIQIKDAIGR 11 1 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 1 19929900.0 5659700.0 6337300.0 7932900.0 True False 8586178.679493546 5206359.301449101 6364958.837886408 1.0 0.6063651242063597 0.7413028630638564 23.03358476509349 -10.39828975502552 5.156840137359453 1.0002573446557492 0.6738339936350917 0.886237098798914 0.055088101207689366 0.00016311606799292551 1.9032649912657457e-05 0.05338040577598738 0.017779608212622575 3.996780013775443e-11 10.39828975502552 -0.32642335102065756 IDIQIK(ub)DAIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDIQIKDAIGR 11 1 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 1 18191600.0 5659700.0 3664200.0 8867700.0 True False 7326593.219365917 3460284.0489093303 7253869.590285702 1.0 0.47229100146613595 0.9900740184554003 22.80471108718594 -10.931581367690015 10.718657289298722 1.0496708566130548 0.7311825099607684 0.2643724348915062 0.21138403151708854 0.11893020524129769 0.0007591464719654338 0.09701387306624328 0.06822390280998894 1.1706272576974091e-11 10.931581367690015 -0.3184883466522864 IDISNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDISNVK 7 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 13114200.0 4295000.0 1118100.0 7701100.0 False True 4158657.575964139 1564563.160814471 5683950.881952185 1.0 0.3762183185884797 1.3667754024288532 21.987686467629818 -6.736476758218281 1.699465505525149 0.627350617323104 1.3669368450700414 0.5890901768652039 0.262117422471112 0.3242230074021474 1.8372174245531603 0.12208214387658095 0.3007601231760905 1.8345233411723184e-07 6.736476758218281 0.7395862277469374 IDISNVK(ub)IPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDISNVKIPK 10 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 92770000.0 30153000.0 34047000.0 28570000.0 True False 39530875.00206742 28967320.314166564 25613850.462791625 1.0 0.7327771093519081 0.6479454467287166 25.23647655327173 -13.999999999999998 0.16057213167686987 2.3176391300632915 0.565075949046869 0.9995348730303943 0.003235389768152821 12.013519922823772 0.12665059331361933 4.929806318858121 0.07558255359888247 1.0000000000000041e-14 13.999999999999998 -1.7525631810164226 IDISNVK(ub)IPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDISNVKIPK 10 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 192907000.0 64496000.0 62372000.0 66039000.0 True False 62448609.78332549 87277464.86568305 48741404.77246635 1.0 1.3975885959432062 0.7805042408723224 25.89616611945507 -6.732768642950315 1.7135297543454155 1.238529429464025 0.7807082975302743 0.5719095134374304 0.16710267679955218 0.3310577532669686 1.9056268217230825 0.07724803713516516 0.19105899569980572 1.8502540224991885e-07 6.732768642950315 -0.45782113193375074 IDISNVK(ub)IPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDISNVKIPK 10 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 128137000.0 34418000.0 27674000.0 66045000.0 True False 52214622.29284398 22735358.482051123 52991176.80144815 1.0 0.4354212954857859 1.0148723571004477 25.63795054294695 -10.852214824873466 12.105839930523604 1.0044672173203903 0.7251468262931197 0.23076329099867798 0.23655990531165622 0.028543027583292465 0.00034844545072562275 0.22921940972224739 0.07634938113770402 1.4053521911232305e-11 10.852214824873466 -0.2793203910272707 IDISNVK(ub)IPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDISNVKIPK 10 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 96188000.0 30153000.0 54406000.0 11629000.0 True False 41301378.95418588 52002163.02341718 8882469.706772882 1.0 1.259090237183153 0.21506472499685503 25.29968661479462 -6.8410167076611 1.2776183696386207 1.1378170002766403 0.1800182046867676 0.9261990586353838 0.1205850603551719 0.16761106738819292 0.5310097910215671 0.07399490583962501 0.1705235888094454 1.4420598732443346e-07 6.8410167076611 -0.9577987955898728 down IDISNVK(ub)IPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDISNVKIPK 10 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 154369100.0 64496000.0 80426000.0 9447100.0 True False 53631281.65725577 79992729.174689 11422444.931544852 1.0 1.4915311867037357 0.21298101739471503 25.676571394889347 -6.8024415424942815 1.445680126701501 1.2703465096466735 0.19418143818672776 0.8393375846623117 0.21107238256320257 0.2172448060222424 0.8960765324504997 0.11484277932089122 0.2667240080849121 1.576008144492564e-07 6.8024415424942815 -1.0761650714599458 down IDISNVK(ub)IPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDISNVKIPK 10 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 94659000.0 34418000.0 36409000.0 23832000.0 True False 44554779.48020855 34382807.14391674 19494820.536969997 1.0 0.7716973924018578 0.43754723431253184 25.4090768650394 -6.965661936408214 0.3465036666827931 1.0336187069129803 0.16441072138819826 0.9999261470267882 0.001984910870804682 0.07773703851663931 0.014071905828553614 0.0046291471389913 0.028788986094110302 1.082276089042447e-07 6.965661936408214 -0.8692079855247821 down IDISNVK(ub)IPK(ub)HLTDAYFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDISNVKIPKHLTDAYFK 18 2 Q02878 Q02878 RPL6 60S ribosomal protein L6 2 16407500.0 3509500.0 9737000.0 3161000.0 True False 2918304.7472112887 9684544.848356834 3821950.4851873377 1.0 3.3185515863657886 1.3096474892965055 21.4766991154771 -6.611392819898216 2.1484703405101446 2.5475604904288733 1.316886387517985 0.05478416630950367 0.9992447957133297 0.6087902178567196 5.327109360014334 0.3837925867257812 1.1091752533356753 2.446849062615979e-07 6.611392819898216 -1.2306741029108883 IDISQLVITK(ub)ELTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDISQLVITKELTR 14 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 34991000.0 10055000.0 14003000.0 10933000.0 True False 13182202.372758523 11913806.983266475 9801758.036741376 1.0 0.9037797058772796 0.7435599727248193 23.652088088185675 -6.963463589842625 0.3835079372138903 1.0105805679235247 0.6310616433275918 0.9998778843111328 0.0011688338262281983 0.07848627210034079 0.016722664991120583 0.0020781973950131697 0.013516138097909794 1.0877683295699661e-07 6.963463589842625 -0.37951892459593284 IDISQLVITK(ub)ELTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDISQLVITKELTR 14 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 66931000.0 10326000.0 16003000.0 40602000.0 True False 9998206.782166637 22393081.354542512 29967118.166109078 1.0 2.2397097642033237 2.9972492886984603 23.25323793436535 -8.609018999290122 0.19332521141200062 4.290657394380901e-16 3.9151322292272237 0.9997061756618059 0.01411167777026694 0.2136094578518614 0.05311488099564857 0.5133640234115945 0.393046649399927 2.4602599716139746e-09 8.609018999290122 3.9151322292272233 IDISQLVITK(ub)ELTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDISQLVITKELTR 14 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 200031000.0 19192000.0 31509000.0 149330000.0 True False 29115667.123140827 25885972.769059315 119814860.04633579 1.0 0.889073661255229 4.115133599364041 24.795292339629317 -6.898938830664535 0.9679797228074568 0.8619389091389531 4.446526432923977 0.9860301166299456 0.1767381880337352 0.11218965929363085 0.18187006970934783 0.13721200093058636 0.355128362163635 1.262005272487204e-07 6.898938830664535 3.584587523785024 up IDISQLVITK(ub)ELTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDISQLVITKELTR 14 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 53720000.0 10055000.0 15271000.0 28394000.0 True False 13772605.226157889 14596276.725556083 21687921.9927861 1.0 1.0598050612700218 1.5747145610181936 23.715298149708566 -6.928754300703954 0.7569387538745131 0.9917977349664497 1.6771489701442501 0.9962879613896459 0.015718108355022225 0.09328928403923763 0.08088409049049915 0.014215395816295358 0.04691338638366697 1.1782723849800073e-07 6.928754300703954 0.6853512351778004 IDISQLVITK(ub)ELTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDISQLVITKELTR 14 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 56926000.0 10326000.0 10471000.0 36129000.0 True False 8586526.519362804 10414590.644669227 43683406.85837808 1.0 1.2128991416009838 5.087436317802204 23.033643209799628 -6.918237047842359 0.8376890711420919 0.9089578718969561 5.687606042365489 0.9936771812463021 0.14938435741786213 0.09922049158188946 0.11106839971170863 0.12752235286919247 0.37578818271378484 1.2071547626281978e-07 6.918237047842359 4.778648170468532 up IDISQLVITK(ub)ELTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDISQLVITKELTR 14 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 233613000.0 19192000.0 21011000.0 193410000.0 True False 24844422.330878083 19841719.379846603 158211364.55418628 1.0 0.7986387896484181 6.368083847840248 24.566418661721766 -6.898509576645829 0.9706237791549992 0.7588786696025943 6.935350725396823 0.9858106511741476 0.30724503706483136 0.11251132334695972 0.18366363049703982 0.2380555156397647 0.6148878067570953 1.263253247449904e-07 6.898509576645829 6.176472055794229 up IDK(ub)TDYMVGSYGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDKTDYMVGSYGPR 14 1 P52565;J3KTF8;J3QQX2 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 1 20755900.0 5261200.0 8082600.0 7412100.0 True False 7206407.818583968 7725484.006416061 5661514.636991255 1.0 1.0720298102604593 0.7856222933139136 22.780848867106148 -6.840095686404739 1.2821364278652299 1.0383157589694592 0.7761952488639684 0.9245871654840421 0.03340514122459535 0.16868965436916603 0.5386549624255804 0.020430709521388788 0.047064700522085674 1.445121337734969e-07 6.840095686404739 -0.26212051010549076 IDKLMIEMDGTENK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDKLMIEMDGTENK 14 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879 P06733 ENO1 Alpha-enolase;Enolase 0 7338200.0 1118500.0 3729300.0 2490400.0 False True 1532039.676325967 3564527.194854057 1902218.8113979865 1.0 2.3266546225501568 1.2416250315133859 20.54702222957497 -6.596440880776169 2.204498088049222 1.8942756134914636 1.2450426549637503 0.0103276966100605 0.5739479106865593 0.6509214464995883 5.973199003472896 0.21655991133621152 0.6387651270479009 2.532556361226995e-07 6.596440880776169 -0.6492329585277132 IDKPILK(ub)AGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDKPILKAGR 10 2 P62917;E9PKZ0;E9PKU4;E9PP36 P62917 RPL8 60S ribosomal protein L8 1 7002900.0 1260900.0 1096400.0 4645600.0 True False 1653052.110572969 932821.3937337267 4164917.8757418487 1.0 0.5643024728424313 2.5195321122080263 20.656700773978727 -6.848234777657825 1.243665209230161 0.7678118548597834 2.5950350432666505 0.9376852079502981 0.20921479774295357 0.15941018557798203 0.4753686119759049 0.13169699736847496 0.30441537219296694 1.4182905928466829e-07 6.848234777657825 1.827223188406867 up IDKPILK(ub)AGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDKPILKAGR 10 2 P62917;E9PKZ0;E9PKU4;E9PP36 P62917 RPL8 60S ribosomal protein L8 1 12599000.0 1694900.0 2500200.0 8403900.0 True False 1641096.3272413546 3498542.898370757 6202666.478404126 1.0 2.1318327512509443 3.779587081783716 20.646228492365164 -6.965749187419529 0.34495236960263664 0.8312257767532776 5.1353673648676965 0.9999277666346537 0.009699580962224537 0.077707630581541 0.013968616894457437 0.022925207783581314 0.14211617416046501 1.0820586785012969e-07 6.965749187419529 4.304141588114419 IDKPILK(ub)AGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDKPILKAGR 10 2 P62917;E9PKZ0;E9PKU4;E9PP36 P62917 RPL8 60S ribosomal protein L8 1 11876300.0 1903100.0 4062100.0 5911100.0 True False 2887141.8352464214 3337186.517667839 4742768.4940728275 1.0 1.1558789654623967 1.6427209900714925 21.461210553233467 -6.950542370670481 0.5528563704150561 0.9933783289768042 1.828205126514338 0.9992431670693188 0.007530756297647241 0.08326866641327775 0.035066556554238085 0.008144031595840281 0.04040992301509015 1.1206180909778757e-07 6.950542370670481 0.8348267975375337 IDKPILK(ub)AGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDKPILKAGR 10 2 P62917;E9PKZ0;E9PKU4;E9PP36 P62917 RPL8 60S ribosomal protein L8 1 6933200.0 1260900.0 1408200.0 4264100.0 True False 1727088.8045412696 1345981.0677053304 3257007.40189614 1.0 0.7793351819351496 1.8858366711266077 20.71991083550162 -6.854874592360703 1.2114353745086606 0.8815614673399387 1.9343836617820638 0.9470882800991369 0.10998930902123855 0.15217909864227244 0.42734366753419134 0.07094792970273908 0.16476364460690154 1.3967716370651335e-07 6.854874592360703 1.052822194442125 IDKPILK(ub)AGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDKPILKAGR 10 2 P62917;E9PKZ0;E9PKU4;E9PP36 P62917 RPL8 60S ribosomal protein L8 1 12280900.0 1903100.0 5288000.0 5089800.0 True False 2463600.4657093626 4993718.15147441 4163508.6257582153 1.0 2.0270000030368283 1.6900096763699002 21.232336875325917 -10.128756482952022 4.42150681175909 0.9999043335981338 1.8585048393611954 0.8964101061154214 0.13757572565633586 45272395.22722141 13.405430304869075 55608.46395510229 0.049643363752487076 7.434358794665107e-11 10.128756482952022 0.8586005057630616 IDKTDYMVGSYGPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDKTDYMVGSYGPR 14 1 P52565;J3KTF8;J3QQX2 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 0 11112800.0 572500.0 5114800.0 5425500.0 False True 750553.044097886 4351691.777334244 4864121.305070905 1.0 5.797980318052915 6.480716244269251 19.517594509977265 -9.642950728672218 0.5377302732871079 3.80125235996119e-15 6.444897604533258 0.9988198165036283 0.08377835459982194 0.9391432863212746 0.2398805339733086 1.9567970551172449 0.12910235216807855 2.275355558459491e-10 9.642950728672218 6.444897604533255 IDKTDYMVGSYGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDKTDYMVGSYGPR 14 1 P52565;J3KTF8;J3QQX2 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 0 15015700.0 572500.0 8753500.0 5689700.0 False True 784168.7212307688 8366741.426046443 4345910.043049761 1.0 10.669567912521009 5.54205992331442 19.580804571500156 -9.705764920100458 8.467466593204525 0.9999897605242771 8.105813917917727 0.7191540223810934 2.0932963709417476 0.0 0.0 2.0268254958296765 0.6756084986098919 1.9689517781178923e-10 9.705764920100458 7.1058241573934495 IDLAVLLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDLAVLLGK 9 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 27256100.0 6352100.0 10072000.0 10832000.0 False True 8327664.6138238935 8569296.8603485 9711208.547880951 1.0 1.029015607343684 1.166138287048734 22.98948053641055 -6.9410704775087355 0.6495253591682074 0.998484771006545 1.204310611902668 0.998300810991214 0.0029866438773657007 0.08728157511374285 0.05241044943136453 0.0029314272784330395 0.011747320973413463 1.1453270621600058e-07 6.9410704775087355 0.2058258408961231 IDLAVLLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDLAVLLGK 9 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 70717000.0 30930000.0 16869000.0 22918000.0 False True 29948144.08022599 23604879.670672867 16915088.274737403 1.0 0.7881917359366045 0.5648125716713782 24.835963264580617 -6.9704527082609316 0.24713609592079408 1.0734349989974352 0.27305054460666417 0.9999856999222546 0.0006719006272285384 0.07615608366786054 0.008502975504375837 0.00508045461992157 0.021510425711775995 1.0704029362235101e-07 6.9704527082609316 -0.800384454390771 IDLAVLLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDLAVLLGK 9 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 158551000.0 46448000.0 77701000.0 34402000.0 False True 70465011.80364975 63834649.46931605 27602429.62106778 1.0 0.9059056095412407 0.39171822887054575 26.070403753962545 -6.9378445339741885 0.6793227867984267 1.0060433551433672 0.26143115355747526 0.9978676882082881 0.012345072814766487 0.08876397094106678 0.0591923397047985 0.011829102279703602 0.04469165328112182 1.1538662377268553e-07 6.9378445339741885 -0.7446122015858919 down IDLAVLLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDLAVLLGK 9 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 71445100.0 6352100.0 22754000.0 42339000.0 False True 8700643.029047973 21748653.0425842 32339400.199076198 1.0 2.499660423945004 3.7168977156180127 23.05269059793344 -7.354604907942042 0.18620844641145914 1.703028564931156e-17 5.785408895879774 0.9999797205091476 0.00500387713204995 0.11872387565679395 0.013233736790616665 0.11727368975873564 0.25789708879163836 4.4197234137817896e-08 7.354604907942042 5.785408895879774 IDLAVLLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDLAVLLGK 9 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 49604900.0 30930000.0 9378200.0 9296700.0 False True 25719665.43132782 9327677.775173044 11240596.986915888 1.0 0.3626671505536566 0.43704289299285703 24.616368540014893 -10.480345447557715 6.152533017414262 1.0003811223212309 0.399855021775379 0.988612259917353 0.030363769702784295 0.00015883227867866204 1.341525298079398e-05 0.02941740091689297 0.009799864532246717 3.308678370973143e-11 10.480345447557715 -0.6005261005458519 IDLAVLLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDLAVLLGK 9 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 120042000.0 46448000.0 49717000.0 23877000.0 False True 60127851.6269605 46950205.245244615 19531630.99870897 1.0 0.7808395606170766 0.32483500524657455 25.841530076054994 -6.959264154176398 0.44568686221784165 1.0153710333210437 0.07235576387089371 0.9997419160027244 0.00451797460088287 0.07996508953899367 0.022110858327165073 0.006057279891964976 0.03774466117399966 1.0983375861514635e-07 6.959264154176398 -0.94301526945015 down IDLIHK(ub)NYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDLIHKNYR 9 1 O00203;O00203-3;Q13367-4;A0A590UJ60;Q13367;A0A2R8Y2A8;A0A590UKC4;A0A5F9UJV3;A0A590UJW5;F5GWU4;A0A590UJU0;A0A590UK04;Q13367-3;A0A590UKD3 O00203 AP3B1;AP3B2 AP-3 complex subunit beta-1;AP-3 complex subunit beta-2 1 6857600.0 1110900.0 5746700.0 0.0 True False 1685316.5176686742 4721156.485827969 0.0 1.0 2.801347068240227 0.0 20.684588137341308 -6.733049261110733 1.7119374473838538 2.0803376735103223 0.0006633995577322239 0.5734066611740718 0.7570803468400681 0.3305583025182328 1.8992318200594116 0.35024672645127775 0.8661872701579809 1.849058872219291e-07 6.733049261110733 -2.07967427395259 IDLIHK(ub)NYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDLIHKNYR 9 1 O00203;O00203-3;Q13367-4;A0A590UJ60;Q13367;A0A2R8Y2A8;A0A590UKC4;A0A5F9UJV3;A0A590UJW5;F5GWU4;A0A590UJU0;A0A590UK04;Q13367-3;A0A590UKD3 O00203 AP3B1;AP3B2 AP-3 complex subunit beta-1;AP-3 complex subunit beta-2 1 11872900.0 1110900.0 3638500.0 7123500.0 True False 1438081.9491127816 3436014.2765014507 5827096.093282375 1.0 2.3893035293442666 4.051991680221962 20.455714459433757 -6.968738100539183 0.28672724842898756 0.662138790228653 5.830293497987294 0.9999707991246775 0.006741949645353083 0.07671431332767559 0.01048851355321878 0.029569725212279314 0.15136031559779878 1.0746372724645503e-07 6.968738100539183 5.168154707758641 IDLK(ub)FIDTTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDLKFIDTTSK 11 1 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 1 10256100.0 2290500.0 4266100.0 3699500.0 True False 3002867.681233556 3629614.5091275587 3316711.2281098184 1.0 1.2087160988846968 1.104514610762782 21.51790947451097 -10.218627366806926 4.431874025026095 0.9999460626935766 1.1566153548265148 0.7507497369330509 0.042540079398964516 2.2679110661846976e-05 3.998517874792643e-06 0.04120342753416899 0.013729751586894557 6.044670515356255e-11 10.218627366806926 0.15666929213293823 IDLK(ub)FIDTTSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDLKFIDTTSK 11 1 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 1 16743400.0 5938800.0 3674600.0 7130000.0 True False 5750276.044734768 5141886.942785847 5262439.10458494 1.0 0.8941982789668 0.9151628658598895 22.45519978430479 -10.222297791527891 4.554373261701394 1.0000273674582325 0.9046805724124846 0.9649898498446926 0.008558756762329664 2.3790347448857227e-06 4.0624633135005427e-07 0.00828935919501331 0.002762326866647395 5.993799462827681e-11 10.222297791527891 -0.09534679504574795 IDLK(ub)FIDTTSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDLKFIDTTSK 11 1 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 1 25943000.0 4167000.0 3855000.0 17921000.0 True False 6321643.648506046 3167045.130747525 14378906.49494668 1.0 0.5009844443693015 2.274551887837707 22.591868282038433 -6.83158338925001 1.3209063476861196 0.7336457804582318 2.323809854510711 0.9089902332928453 0.225285425427337 0.1788648495778017 0.6098040228455726 0.1338927986230682 0.3081044049007804 1.473725542520067e-07 6.83158338925001 1.590164074052479 up IDLK(ub)FIDTTSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDLKFIDTTSK 11 1 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 1 13446100.0 5938800.0 4468300.0 3039000.0 True False 4938375.333448752 4444228.38101189 3674440.849251598 1.0 0.8999373439499645 0.7440586430042619 22.235605059739065 -6.9646213125757175 0.3644963873908305 1.0127606439016144 0.6258560451859297 0.9999051180490705 0.001025806004214398 0.07808973931563024 0.01531471386172946 0.0020734378915685824 0.013279071581852315 1.0848724671350715e-07 6.9646213125757175 -0.3869045987156846 IDLK(ub)FIDTTSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDLKFIDTTSK 11 1 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 1 18529600.0 4167000.0 4084600.0 10278000.0 True False 5394263.643849998 3857288.4193480276 8407509.461185697 1.0 0.7150722830808842 1.5586018808648892 22.362994604130883 -6.81557795099893 1.3907985462688806 0.8457008292606991 1.5753416624830083 0.8739215782871841 0.12440375800699993 0.1992969128137628 0.7586365083953729 0.0703088790883727 0.16228021004510268 1.5290512741964108e-07 6.81557795099893 0.7296408332223092 IDLPEYQGEPDEISIQK(ub)CQEAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDLPEYQGEPDEISIQKCQEAVR 23 1 Q9BY32;Q9BY32-2 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 1 11932700.0 2951700.0 4690300.0 4290700.0 True False 3869707.2843034607 3990525.522646202 3846739.5233006636 1.0 1.0312215445423512 0.9940647291085917 21.8837930102532 -6.6838529195933525 1.8880456463399888 1.0196852675605859 0.9942010651174719 0.3419142139402169 0.013221392186435098 0.43001897041679693 2.966873284401852 0.005612075792040392 0.014729642014934893 2.0708425522551022e-07 6.6838529195933525 -0.025484202443114 IDLPEYQGEPDEISIQK(ub)CQEAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDLPEYQGEPDEISIQKCQEAVR 23 1 Q9BY32;Q9BY32-2 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 1 15384100.0 4570600.0 5431300.0 5382200.0 True False 4425508.8048199555 7600046.413855327 3972440.3574610217 1.0 1.7173271479152605 0.8976234219971536 22.077411902032058 -6.675504736610368 1.9180090250832504 1.4556809326497389 0.9008535122786373 0.3036358031738283 0.30432356544055517 0.44857154811297995 3.1864624691673207 0.12750526585540162 0.3382171419572617 2.1110341717976698e-07 6.675504736610368 -0.5548274203711016 IDLPEYQGEPDEISIQK(ub)CQEAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDLPEYQGEPDEISIQKCQEAVR 23 1 Q9BY32;Q9BY32-2 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 1 101290000.0 14672000.0 26106000.0 60512000.0 True False 22258496.666878 21447180.332891036 48551776.676648155 1.0 0.9635502636979858 2.181269355396142 24.407852820930938 -6.899998702851851 0.9612629363003261 0.9493698868324946 2.309092019447419 0.9865660428942756 0.0655607955833408 0.11140668771510315 0.1774195752883555 0.0511519995649722 0.1330898275861307 1.2589291719506392e-07 6.899998702851851 1.3597221326149245 up IDLPEYQGEPDEISIQK(ub)CQEAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDLPEYQGEPDEISIQKCQEAVR 23 1 Q9BY32;Q9BY32-2 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 1 17246700.0 4570600.0 1739100.0 10937000.0 True False 3800656.4119116454 1729731.1231156786 13223876.133025581 1.0 0.4551137844753671 3.4793663777605897 21.857817177466334 -6.860276455234628 1.1842142298829683 0.7041128481606843 3.626676412902045 0.953983766552796 0.2823325762450139 0.1465238290213215 0.390274026683078 0.18591873712171028 0.4341614824640187 1.3795058444597835e-07 6.860276455234628 2.9225635647413606 up IDLPEYQGEPDEISIQK(ub)CQEAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDLPEYQGEPDEISIQKCQEAVR 23 1 Q9BY32;Q9BY32-2 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 1 111161000.0 14672000.0 24569000.0 71920000.0 True False 18993193.228357833 23201713.55211328 58831297.96151731 1.0 1.221580451120347 3.0974937839140764 24.178979143023387 -6.929057726415791 0.7544857866152074 0.9704531152514249 3.4735289877320388 0.9963497887582776 0.05684631160629314 0.09313014116045984 0.08009866986310978 0.051502317253875454 0.1706259051997316 1.1774494565554396e-07 6.929057726415791 2.503075872480614 up IDLRPVLGEGVPILASFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDLRPVLGEGVPILASFLR 19 1 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 268553000.0 110560000.0 46483000.0 111510000.0 False True 91935538.63846135 46232586.852846935 134826225.43601397 1.0 0.5028804697023385 1.4665299995273997 26.45411932231389 -6.766486835043137 1.587766554348937 0.7135831223499658 1.471259695802621 0.7169577510553373 0.20933509564741146 0.2721671605306589 1.3535246038189972 0.10395236906556748 0.24826942811895164 1.712037073638116e-07 6.766486835043137 0.7576765734526552 IDLTLLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDLTLLNR 8 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 7591700.0 1976200.0 2585800.0 3029700.0 False True 2590817.33754802 2200008.7193694566 2716215.7069345373 1.0 0.8491562440490579 1.0484010846959964 21.30497587295364 -6.704239956868744 1.815811506711837 0.9067242197334726 1.0478569113558636 0.43771643284192474 0.06362491594131565 0.38675435621138193 2.482002886993104 0.027923575883753646 0.07143695464008684 1.9758776243626413e-07 6.704239956868744 0.14113269162239095 IDLTLLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDLTLLNR 8 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 6414570.0 3417300.0 711670.0 2285600.0 False True 3308819.6820354443 995843.5423100214 1686932.7934697566 1.0 0.30096639829506244 0.5098291703922735 21.65788524177803 -10.296729772591421 6.379563823898734 1.0000193940697348 0.40539778434389034 0.9152981529958323 0.08526786965023038 2.352134658180311e-05 2.5929209754413187e-06 0.08256294604207676 0.027520086593493857 5.049754064374544e-11 10.296729772591421 -0.5946216097258445 IDLTLLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDLTLLNR 8 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 11027600.0 1976200.0 3850100.0 5201300.0 False True 2706854.544796934 3679989.8514218745 3972860.064136024 1.0 1.3595077942017548 1.467703564557092 21.368185934476532 -12.35199238707933 0.1925297202177242 2.1420341638400588e-10 1.5498448557802573 0.99943404496485 0.004755967583872254 6.212400247917893 0.1260048483293502 2.4943589328103126 0.0725658639998675 4.4463906165571726e-13 12.35199238707933 1.549844855566054 IDLVK(ub)ESQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDLVKESQAK 10 1 P41091 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 31455600.0 9830000.0 14219200.0 7406400.0 True False 12887225.193855407 12097750.786007477 6640056.775205454 1.0 0.9387397677954484 0.5152433262647893 23.6194383282209 -6.93291769016811 0.7224494544990088 1.0057950886299243 0.42147113232696587 0.9970810703932936 0.01164463704176486 0.09115127007162692 0.07046645887459514 0.010799221762747965 0.03772333253539631 1.1670307780680796e-07 6.93291769016811 -0.5843239563029584 IDLVK(ub)ESQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDLVKESQAK 10 1 P41091 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 46421500.0 19358900.0 13741200.0 13321400.0 True False 18744362.316026088 19228132.81941134 9832125.706566317 1.0 1.0258088536291063 0.5245377538482613 24.159953410127986 -6.894767402112781 0.9937822115801591 1.0239372375227622 0.47717621129088833 0.9837774468836351 0.029353083041569264 0.11535915801790528 0.19994782281696913 0.02235307422706185 0.05677149050396105 1.274185321927316e-07 6.894767402112781 -0.5467610262318738 IDLVK(ub)ESQAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDLVKESQAK 10 1 P41091 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 95926000.0 39252000.0 10750000.0 45924000.0 True False 59548153.70558183 8831578.50986665 36847101.27079577 1.0 0.14830986286378867 0.6187782320334452 25.82755344213982 -10.77323380536052 12.796608016048248 1.0007727943644353 0.38354404760724503 0.6959738476310101 0.19206790743083385 0.004237745614344269 7.509616542227112e-05 0.18610557129874436 0.061989650568377255 1.6856453025651434e-11 10.77323380536052 -0.6172287467571903 IDLVK(ub)ESQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDLVKESQAK 10 1 P41091 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 30376200.0 9830000.0 10152700.0 10393500.0 True False 13464416.645761501 9704120.143510781 7938769.360851656 1.0 0.7207233999673923 0.5896110889698828 23.682648389743793 -13.999999999734985 0.1008452801106429 2.3758661018934726 0.31397941761118126 0.9997894753457554 0.0024831662986722373 12.074033920761662 0.0947420508520922 3.4498810292450455 0.2457103395786029 1.0000000006102188e-14 13.999999999734985 -2.061886684282291 IDLVK(ub)ESQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDLVKESQAK 10 1 P41091 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 52881100.0 19358900.0 25708000.0 7814200.0 True False 16097783.094682578 25569505.90136153 9448113.091221416 1.0 1.5883867828861262 0.5869201389812687 23.940358685562263 -6.747524953128732 1.659460233569725 1.3470124395562753 0.5853531416569119 0.6380709790725382 0.24721755080480773 0.30437830189343146 1.648449754932438 0.11773429845573265 0.28652278593107217 1.788442768132042e-07 6.747524953128732 -0.7616592978993634 IDLVK(ub)ESQAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDLVKESQAK 10 1 P41091 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 122831000.0 39252000.0 27762000.0 55817000.0 True False 50812487.77259425 26217020.295240644 45658878.73078444 1.0 0.5159562431300758 0.8985759354103222 25.59867976423227 -9.882449528234854 6.566195143628906 1.0000000134405964 0.7072660892701853 0.43834712101988316 0.15620383527127205 3.067292289653296e-08 5.148431708176388e-09 0.15124371991593252 0.05041457105160592 1.3108423737607788e-10 9.882449528234854 -0.2927339241704111 IDNQK(ub)FVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDNQKFVR 8 1 Q8N999;Q8N999-3 Q8N999 C12orf29 Uncharacterized protein C12orf29 1 8076400.0 1394800.0 1531000.0 5150600.0 True False 2116013.573538809 1257781.0882424025 4132581.652411826 1.0 0.5944106899744015 1.9530033758245322 21.012917451225224 -6.82669125479279 1.3426227260865675 0.7827373770071362 1.9871549195964688 0.8990988370523075 0.1808864768763067 0.1849265955186478 0.6531079167179 0.10581620905494446 0.2435729040478925 1.4904202589874783e-07 6.82669125479279 1.2044175425893326 IDNQK(ub)FVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDNQKFVR 8 1 Q8N999;Q8N999-3 Q8N999 C12orf29 Uncharacterized protein C12orf29 1 2285700.0 708480.0 858740.0 718480.0 True False 589132.510985682 854113.7971734565 868710.8461238215 1.0 1.4497821478981567 1.4745593392399527 19.168232644045094 -11.698670861761114 0.463787529916905 5.474901679335352e-23 1.4742679913784709 0.9998277246466843 0.0028626908866628813 4.800116477014138 0.23006125419170403 4.767892953423631 0.005422661053885614 2.001378077023403e-12 11.698670861761114 1.4742679913784709 IDNQK(ub)FVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDNQKFVR 8 1 Q8N999;Q8N999-3 Q8N999 C12orf29 Uncharacterized protein C12orf29 1 6518900.0 1394800.0 1318700.0 3805400.0 True False 1805596.0956184217 1245313.185769537 3112856.2467013076 1.0 0.6896964325473985 1.724004750705415 20.784043773317673 -6.826268979689229 1.3444194094844848 0.8337165761380368 1.7497896679728702 0.8982162274818846 0.13825963328894206 0.18546332019996803 0.656884385864845 0.08077315408856296 0.18594358912127792 1.4918701356708252e-07 6.826268979689229 0.9160730918348333 IDNSQVESGSLEDDWDFLPPKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDNSQVESGSLEDDWDFLPPKK 22 1 P27797;K7EJB9 P27797 CALR Calreticulin 0 13004800.0 1139300.0 5762800.0 6102700.0 False True 1493633.3329968948 4903012.703218458 5471251.145232009 1.0 3.2826079834338104 3.663048369611729 20.51039459858148 -10.002040693920565 0.4277627316424 5.445682080661864e-24 3.6870685426670313 0.9989711463134132 0.037721196856609074 1.3199110712065336 0.19243498629969577 1.7800698629546534 0.08987740662021389 9.953121510242877e-11 10.002040693920565 3.6870685426670313 IDNSQVESGSLEDDWDFLPPKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDNSQVESGSLEDDWDFLPPKK 22 1 P27797;K7EJB9 P27797 CALR Calreticulin 0 22292300.0 6943200.0 2683100.0 12666000.0 False True 6722791.916515526 3754475.822181662 9348394.628144858 1.0 0.5584697353131279 1.3905524288471807 22.680629065367384 -6.762566094705908 1.603060529301221 0.7443521898028784 1.3939577718671667 0.7012688704604393 0.18578156535294926 0.2786234531519372 1.4117711861411693 0.09141980088092717 0.21912120757268508 1.7275630449531764e-07 6.762566094705908 0.6496055820642883 IDNSQVESGSLEDDWDFLPPKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDNSQVESGSLEDDWDFLPPKK 22 1 P27797;K7EJB9 P27797 CALR Calreticulin 0 15585800.0 1139300.0 6053800.0 8392700.0 False True 1560529.9984248313 5786323.098760485 6410517.113082184 1.0 3.7079217346677646 4.107910209706213 20.573604660104372 -9.94275959534529 0.46421646424040636 3.777012556035531e-18 4.114239242700477 0.9990216033623289 0.04318101044619933 1.2404569522960023 0.20899359143985127 1.8679377388334326 0.08690436594997908 1.1408811500401433e-10 9.94275959534529 4.114239242700477 IDPFGGDPFK(ub)GSDPFASDCFFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDPFGGDPFKGSDPFASDCFFR 22 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 8568800.0 3180700.0 1614800.0 3773300.0 True False 2644892.9789015357 1606100.751887294 4562279.584232002 1.0 0.6072460264741343 1.7249392019357945 21.33477791664203 -6.811748819336478 1.4071295061440485 0.7863889224872618 1.74529170069884 0.8643488188235801 0.17051401844204658 0.20442911248711537 0.7974277621283621 0.09527326634885508 0.22022132749180803 1.542592376206714e-07 6.811748819336478 0.9589027782115782 IDPSLGIIAK(ub)INR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDPSLGIIAKINR 13 1 P50416;P50416-2;H3BUJ0;H3BP22;H3BUV7 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 1 10383100.0 1441000.0 2539300.0 6402800.0 True False 1395256.2437635215 3553255.7322745663 4725714.600117323 1.0 2.5466689349406693 3.3869868859144647 20.41209867177874 -8.880964742253289 0.22946299726479485 8.960841767650623e-24 4.0930904859312855 0.9993763976160982 0.02468742850909985 0.3840635728333375 0.07339273051746217 0.6828600123470432 0.38205162068878995 1.3153316116893561e-09 8.880964742253289 4.0930904859312855 IDPSLGIIAK(ub)INR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDPSLGIIAKINR 13 1 P50416;P50416-2;H3BUJ0;H3BP22;H3BUV7 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 1 10306700.0 1441000.0 3568800.0 5296900.0 True False 1198255.3471239395 3549574.1660486613 6404457.299901545 1.0 2.962285271305797 5.344818460667475 20.192503947213016 -6.968532291056809 0.2911203336145059 0.5406631883123934 7.840165771320001 0.9999685614170674 0.009961013746170377 0.07678192996563513 0.010726267094655491 0.04137523005530456 0.21578019697906337 1.0751466571423737e-07 6.968532291056809 7.299502583007607 IDPSLGIIAK(ub)INR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDPSLGIIAKINR 13 1 P50416;P50416-2;H3BUJ0;H3BP22;H3BUV7 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 1 19933600.0 2591600.0 9478200.0 7863800.0 True False 3354877.2880733474 8950729.837992594 6432669.089401838 1.0 2.667975329474079 1.9174081604326034 21.677828567008728 -10.12889268063434 4.698207889700474 0.9998969158298603 2.292691744966354 0.7981847922285055 0.306417763693016 0.0003352229098002459 6.215423201490378e-05 0.29671130482637 0.09889590797284274 7.432027695086222e-11 10.12889268063434 1.2927948291364937 IDPSSLSFNMWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDPSSLSFNMWK 12 0 Q8WTV0-4;Q8WTV0-2;B7ZKQ9;Q8WTV0-5;Q8WTV0;F5H5E8 Q8WTV0-4 SCARB1 Scavenger receptor class B member 1 0 4577530.0 931430.0 1863700.0 1782400.0 False True 1221113.749980952 1585643.2246456996 1597974.3459880922 1.0 1.2985221275826548 1.3086203852941785 20.219766166774555 -11.981358775488198 0.5212636536129591 3.1830854412776693e-14 1.3079443841448342 0.9999187710986529 0.0012902844763759461 6.606937184197683 0.25825300085156827 7.353981027019088 0.001978833367268272 1.04385752065235e-12 11.981358775488198 1.3079443841448024 IDPSSLSFNMWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDPSSLSFNMWK 12 0 Q8WTV0-4;Q8WTV0-2;B7ZKQ9;Q8WTV0-5;Q8WTV0;F5H5E8 Q8WTV0-4 SCARB1 Scavenger receptor class B member 1 0 2467330.0 931430.0 0.0 1535900.0 False True 1275804.8419493034 0.0 1173152.0528534232 1.0 0.0 0.9195387995713851 20.282976228297446 -10.001025825078417 12.793342477913988 1.0000119243647303 0.45976939978569864 0.31516745748838004 0.3754001430033391 0.0 0.0 0.36347962547542934 0.12115987515847641 9.976407379102927e-11 10.001025825078417 -0.5402425245790317 IDPTVTMMQVEEK(ub)PDVTYSDVGGCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDPTVTMMQVEEKPDVTYSDVGGCK 25 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 130138000.0 14539000.0 26244000.0 89355000.0 True False 22056725.943275567 21560553.154692113 71693945.08431219 1.0 0.9775046944927599 3.250434596172217 24.394715320238134 -6.904663189054443 0.9312934131942439 0.9172056411679886 3.512981615789372 0.98874746083355 0.11310106893434567 0.10805453398388246 0.15868476907586151 0.09022035221343269 0.24074218519643822 1.2454801518411705e-07 6.904663189054443 2.5957759746213833 up IDPTVTMMQVEEK(ub)PDVTYSDVGGCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDPTVTMMQVEEKPDVTYSDVGGCK 25 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 9213800.0 2099000.0 3134400.0 3980400.0 True False 2875057.0233421535 2995911.8439252824 3040311.498911241 1.0 1.0420356255900063 1.0574786775453187 21.455159139808003 -13.999999748203075 0.13918955949586187 0.7993422231402163 1.0767781610155203 0.9996061283317078 0.0004819952866108742 11.933230113674774 0.11682953688782073 0.6506610499674939 0.01724421766643659 1.0000005797840132e-14 13.999999748203075 0.27743593787530396 IDPTVTMMQVEEK(ub)PDVTYSDVGGCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDPTVTMMQVEEKPDVTYSDVGGCK 25 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 12733900.0 5446800.0 2014300.0 5272800.0 True False 4529255.53415314 2003448.5660927542 6375318.101327359 1.0 0.4423350705177976 1.4075863137449116 22.110842505809956 -6.7500039271905266 1.6494904151579426 0.6721076462087516 1.409552927749761 0.6492012865178205 0.23433466274238157 0.29999901045202954 1.6059009209382875 0.1122183022301709 0.27247090075204694 1.7782633296815425e-07 6.7500039271905266 0.7374452815410093 IDPTVTMMQVEEK(ub)PDVTYSDVGGCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDPTVTMMQVEEKPDVTYSDVGGCK 25 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 120616000.0 14539000.0 18493000.0 87584000.0 True False 18821022.10653588 17463848.293346524 71644610.68772982 1.0 0.9278905361511659 3.8066269877473955 24.165841642330584 -6.901154574524409 0.9539315793086989 0.8840748038428237 4.115994307463 0.9871322581156531 0.15204702266569403 0.11056068018669621 0.17266191649728635 0.11927775118504531 0.3121801345756884 1.2555829958069619e-07 6.901154574524409 3.231919503620176 up IDPTVTMMQVEEKPDVTYSDVGGCK(ub)EQIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDPTVTMMQVEEKPDVTYSDVGGCKEQIEK 30 2 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 243276900.0 60343900.0 10162000.0 172771000.0 True False 91546108.03001772 8348511.7039316 138622736.12178075 1.0 0.09119461092976389 1.5142395357356615 26.447995217135876 -6.734193198088473 1.7077509341451793 0.4556428421846228 1.514086338831228 0.5785935284607321 0.3819337993220235 0.3284745124312874 1.8785272678636702 0.17708943916738631 0.437396713284852 1.84419483730764e-07 6.734193198088473 1.0584434966466052 IDPTVTMMQVEEKPDVTYSDVGGCK(ub)EQIEK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IDPTVTMMQVEEKPDVTYSDVGGCKEQIEK 30 2 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 401516700.0 85348900.0 72137800.0 244030000.0 True False 110485833.52833916 68123268.01577736 199619043.95924756 1.0 0.6165792105673351 1.8067388151445325 26.71928615850178 -6.819993440916334 1.3718312961167676 0.7933312048985187 1.832730943247806 0.8843726914331066 0.16866657927581308 0.19349807020705204 0.7155219516223452 0.09661508618208087 0.22269036874114465 1.5135841076947152e-07 6.819993440916334 1.0393997383492874 IDQK(ub)AVDSQILPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDQKAVDSQILPK 13 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 3034400.0 1505400.0 1529000.0 0.0 True False 1973593.9783143355 1300879.1599953182 0.0 1.0 0.6591422421679716 0.0 20.912393788235924 -7.514114965481758 0.7096974874283365 0.9935324150948851 5.532825341734739e-17 0.9870721390507995 0.047195361928712126 0.11950960482608339 0.14293208413388875 0.0418069641361536 0.07581497482998958 3.061152984727905e-08 7.514114965481758 -0.9935324150948851 down IDQLQEELLHTQLK(ub)YQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDQLQEELLHTQLKYQR 17 1 O60313-10;O60313-11;A0A2R8Y3X5;E5KLJ9;C9JMB8;A0A2R8YE78;O60313-2;O60313;O60313-9;O60313-13;A0A2R8YGE5;A0A2R8Y4Q3;A0A2R8YD53;A0A2R8Y4G4;A0A2R8YE54 O60313-10 OPA1 Dynamin-like 120 kDa protein, mitochondrial;Dynamin-like 120 kDa protein, form S1 1 7831300.0 1685100.0 1293300.0 4852900.0 True False 1401235.3125874747 1286332.7362000493 5867618.952725592 1.0 0.9179990859813187 4.187461520571189 20.418267820450673 -6.9011495176677835 0.9539927714220205 0.86832199650755 4.538746785066188 0.9871290062835725 0.17270324525428643 0.1105633988017881 0.17269493527884205 0.13547869817880676 0.3545612722901246 1.2555976157029577e-07 6.9011495176677835 3.6704247885586376 up IDQVNQLLELDHQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDQVNQLLELDHQKR 15 1 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 1 27660100.0 8463400.0 11673000.0 7523700.0 True False 11095599.359682186 9931433.900997633 6745219.696426507 1.0 0.8950786324428086 0.6079184618846685 23.40348426503951 -6.9534938950138026 0.519072153742425 1.004914823487112 0.4852876038442035 0.9994477107690081 0.0038947850645521713 0.08211238326277767 0.030385407159561464 0.00441883817633405 0.023717446370094854 1.1130280388054548e-07 6.9534938950138026 -0.5196272196429084 IDQVNQLLELDHQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDQVNQLLELDHQKR 15 1 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 1 32446200.0 8173200.0 12866000.0 11407000.0 True False 7913746.239783495 18003460.895303626 8419164.497335264 1.0 2.2749606001766574 1.0638658660813463 22.9159293742765 -6.6341656634999495 2.065976410916551 1.8374362854187027 1.0688731611920175 0.13245215801770627 0.5463245970653773 0.5482449202101024 4.464979937094614 0.21591348490453183 0.6048650560270432 2.3218509473719356e-07 6.6341656634999495 -0.7685631242266853 IDQVNQLLELDHQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDQVNQLLELDHQKR 15 1 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 1 159276000.0 23388000.0 49562000.0 86326000.0 True False 35481305.89183091 40717273.87032651 69263628.26197007 1.0 1.1475697651731895 1.9521160938418864 25.08055577331493 -6.937895230290678 0.6788675439588757 0.9905560840080971 2.156267449765172 0.997874950716408 0.01928793610000919 0.08874016929498538 0.05908273891823652 0.018488417640009792 0.06991213690866008 1.1537315518021995e-07 6.937895230290678 1.1657113657570748 IDQVNQLLELDHQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDQVNQLLELDHQKR 15 1 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 1 32887900.0 8463400.0 16678000.0 7746500.0 True False 11592547.69478514 15941110.813229274 5916936.244175434 1.0 1.375117121182975 0.5104086176705698 23.4666943265624 -6.788807488500259 1.5011448623461296 1.2099771559157535 0.5015177269331463 0.7974275139787025 0.15934894677742822 0.23713086124822114 1.0556741712760533 0.08356056124531186 0.195802775154874 1.6262694791549032e-07 6.788807488500259 -0.7084594289826072 IDQVNQLLELDHQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDQVNQLLELDHQKR 15 1 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 1 46885300.0 8173200.0 31200000.0 7512100.0 True False 6796377.934152244 31031919.407284904 9082845.377973983 1.0 4.5659496437576665 1.3364244110575563 22.696334649710778 -6.622510579964162 2.1073059347531524 3.3619929131802673 1.3489026688754884 0.09121147158720389 1.5325187260232898 0.5788544380940914 4.887953409850491 0.5968032708616817 1.6990775494149088 2.3850056929950775e-07 6.622510579964162 -2.013090244304779 IDQVNQLLELDHQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDQVNQLLELDHQKR 15 1 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 1 148425000.0 23388000.0 26173000.0 98864000.0 True False 30276227.046403587 24716449.54208394 80871766.43030374 1.0 0.8163649157539241 2.671130927455184 24.85168209540738 -6.882551741262795 1.0654344646365492 0.8818325696711682 2.809199292127774 0.975687403612747 0.13010947527247213 0.12539511706965528 0.2588143030854934 0.09384224442470876 0.22848593693299532 1.3105338978118364e-07 6.882551741262795 1.9273667224566058 up IDQYQGADAVGLEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDQYQGADAVGLEEK 15 0 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 0 20576500.0 2056100.0 6347400.0 12173000.0 False True 2695567.0113007226 5400392.661971414 10913454.731661273 1.0 2.003434765053569 4.048667566381546 21.362157344472685 -6.959672744536134 0.4400213562087465 0.9268874685979719 5.204958387556429 0.9997578696835031 0.01974017756355119 0.07981822320171486 0.021564800008145427 0.02696588660119528 0.1694596372482571 1.0973047406291717e-07 6.959672744536134 4.278070918958457 IDQYQGADAVGLEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDQYQGADAVGLEEK 15 0 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 0 15417100.0 5214200.0 1391700.0 8811200.0 False True 5048678.075108784 1947413.0676196248 6503282.389666046 1.0 0.38572732082499905 1.2881158776450445 22.26747425735865 -6.723424392801304 1.7470385374261166 0.6276553626929557 1.2869828874042835 0.5285999348428528 0.25838571083694883 0.3487094205007038 2.0817938607873594 0.1173530823636086 0.2934152239408501 1.890495322668019e-07 6.723424392801304 0.6593275247113277 IDQYQGADAVGLEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDQYQGADAVGLEEK 15 0 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 0 15031500.0 2056100.0 5839400.0 7136000.0 False True 2816295.734013248 5581395.999686484 5450623.770533261 1.0 1.9818217001425993 1.9353875747864273 21.425367405995576 -10.289034483419782 5.497017837299224 0.9998815733622762 1.9586046374645423 0.9982433177905239 0.018956652295944176 2.751647864695354e-05 3.558879942035674e-06 0.01835692538735621 0.0061182332201548785 5.1400283761851374e-11 10.289034483419782 0.958723064102266 IDQYQGADAVGLEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDQYQGADAVGLEEK 15 0 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 0 6048190.0 5214200.0 0.0 833990.0 False True 4335838.328225988 0.0 1008373.4530659234 1.0 0.0 0.23256712467840107 22.047879532792926 -10.200622917707726 4.864955907077654 1.000114015678511 0.11628356233712969 0.950621307049846 0.09494513107517574 254389120.12401846 266696307.6024104 269193.72767091636 0.03250222627441484 6.300529978100159e-11 10.200622917707726 -0.8838304533413814 IDQYQGADAVGLEEK(ub)IK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDQYQGADAVGLEEKIK 17 1 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 1 149062900.0 14993000.0 29503000.0 104566900.0 True False 14517055.421753274 41283701.756112546 77177691.95024176 1.0 2.843806857294933 5.316346167184416 23.791245517046498 -6.967052520218616 0.32088234376571023 0.6648731671940967 7.5751335856436866 0.9999494153124125 0.012577100133579473 0.07727123130076068 0.012439779527647694 0.03734579431974206 0.2173211243877994 1.0788162506401106e-07 6.967052520218616 6.91026041844959 IDQYQGADAVGLEEK(ub)IK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDQYQGADAVGLEEKIK 17 1 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 1 620066000.0 39013000.0 265932000.0 315121000.0 True False 59185573.23234134 218474356.86380038 252837196.22755948 1.0 3.691344781035547 4.271939636962056 25.818742219075265 -9.734464799900913 0.40941129985290026 3.443055529194968e-24 4.332583909452528 0.99861486662756 0.05304984119413504 1.0533208180083307 0.17665795200227627 1.5609599319779977 0.14333140011174084 1.8430418637148573e-10 9.734464799900913 4.332583909452528 IDQYQGADAVGLEEK(ub)IK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDQYQGADAVGLEEKIK 17 1 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 1 92837400.0 9167000.0 11838000.0 71832400.0 True False 12556287.628860189 11314958.016968958 54867066.55471601 1.0 0.9011388040332815 4.369688571692637 23.581906646665466 -6.900338646090319 0.9591146093282016 0.8571273565434706 4.736298368866038 0.9867343245292819 0.18569866393536338 0.11115676951245841 0.17601306382821522 0.14511782894243566 0.37822146881713437 1.2579441329344375e-07 6.900338646090319 3.8791710123225673 up IDQYQGADAVGLEEK(ub)IK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDQYQGADAVGLEEKIK 17 1 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 1 97122000.0 14993000.0 28428000.0 53701000.0 True False 12467343.802518541 28274852.721483823 64929630.81462984 1.0 2.2679131312454857 5.207976281324121 23.571650792480774 -6.957052858342536 0.4751501348461052 0.926106803491187 6.67136189851696 0.9996447987147761 0.03321804120731155 0.0807711769429819 0.02515230765967325 0.04105501244249198 0.24258200770455066 1.103944249752451e-07 6.957052858342536 5.745255095025772 IDQYQGADAVGLEEK(ub)IK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDQYQGADAVGLEEKIK 17 1 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 1 571026100.0 39013000.0 204253100.0 327760000.0 True False 50503097.56119989 192886235.43209514 268111043.10159758 1.0 3.819295147161116 5.308803935772442 25.589868541167714 -8.69077376983807 0.29908414100634867 3.2210471002845144e-25 6.058547565763946 0.9986835813124723 0.06482837532353267 0.26800017807082765 0.09167507373400607 0.7823098957864719 0.493975188908062 2.0381034782721347e-09 8.69077376983807 6.058547565763946 IDSDISGTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDSDISGTLK 10 0 Q9Y2B0;H0YI18 Q9Y2B0 CNPY2 Protein canopy homolog 2 0 7161200.0 2066600.0 658400.0 4436200.0 False True 2000996.9141996454 921302.5535106413 3274226.1368526965 1.0 0.46042177625203484 1.6362974443477913 20.93228751174409 -6.7819421052997475 1.5283649302701467 0.6952488986501344 1.6461769416328753 0.774187282395066 0.22837530075267742 0.24756549616543191 1.1423510089445224 0.11767693848789788 0.2772137188328656 1.6521820317621545e-07 6.7819421052997475 0.9509280429827409 IDSEGGVSANHTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDSEGGVSANHTSR 14 0 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ET17;A0A2R8Y7L2;E7EPL9;E7ER27 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 3650880.0 284780.0 1732000.0 1634100.0 False True 373349.3378134433 1473592.3512831214 1465019.0073940433 1.0 3.9469531670080316 3.9239898374376923 18.5101666466605 -10.17342579009649 4.40434690608305 0.9993284987368687 3.935471502315248 0.9999541060427758 0.009374740361737435 1643267.473871049 14.309553309881773 11193.436472905134 0.0032092229316434784 6.70770894630307e-11 10.17342579009649 2.936143003578379 IDSEGGVSANHTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDSEGGVSANHTSR 14 0 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ET17;A0A2R8Y7L2;E7EPL9;E7ER27 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 3333480.0 284780.0 1630000.0 1418700.0 False True 390070.8618901287 1557981.2103108119 1083632.2790436575 1.0 3.9940978999596455 2.7780395433609297 18.573376708183392 -8.928066833196759 12.193289573868169 0.9999632177474559 3.3860730330090303 0.836955369172925 0.49645374565710376 0.0 0.0 0.4806892720826288 0.16022975736087622 1.1801390111201311e-09 8.928066833196759 2.3861098152615745 IDSIPHLNNSTPLVDPSVYGYGVQK(ub)RPLDDGVGNQLGALVHQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDSIPHLNNSTPLVDPSVYGYGVQKRPLDDGVGNQLGALVHQR 43 2 Q96I24 Q96I24 FUBP3 Far upstream element-binding protein 3 1 62019100.0 8160100.0 16166000.0 37693000.0 True False 12379468.28321915 13281050.994465511 30242962.028571185 1.0 1.07282887201775 2.442993619489029 23.561446014172695 -6.917895367334614 0.8401865759533327 0.9674145580049247 2.6535931724834727 0.9935760780029526 0.05319786808087799 0.09942606622356402 0.11214728247235743 0.04533174511790155 0.13317474967761997 1.2081048634551673e-07 6.917895367334614 1.686178614478548 up IDSIPHLNNSTPLVDPSVYGYGVQK(ub)RPLDDGVGNQLGALVHQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDSIPHLNNSTPLVDPSVYGYGVQKRPLDDGVGNQLGALVHQR 43 2 Q96I24 Q96I24 FUBP3 Far upstream element-binding protein 3 1 61184100.0 8160100.0 12366000.0 40658000.0 True False 10563410.30961852 11677821.229412377 33258661.18630941 1.0 1.1054972671826568 3.1484776423032357 23.332572336265144 -6.917604788268896 0.842295834198805 0.9509151432210349 3.4604404626804577 0.9934893844983121 0.07979068486319144 0.09960178946518258 0.11306686583930729 0.0678897222846093 0.19893136709512577 1.2089134563895327e-07 6.917604788268896 2.509525319459423 up IDSK(ub)LGHVVMGNNAVSPYQQVIEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDSKLGHVVMGNNAVSPYQQVIEK 24 1 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 20851200.0 4229200.0 8692500.0 7929500.0 True False 5544522.155631061 7395612.883099623 7109031.405134967 1.0 1.3338593796741491 1.282172062008081 22.40263169906965 -10.099266214428088 4.532887411155713 0.9999745523293962 1.3080157208523826 0.9793173132889925 0.021101259114187594 5.427108884321088e-06 1.07843550094832e-06 0.020432892779515262 0.006810402089044334 7.956714691114049e-11 10.099266214428088 0.30804116852298635 IDSK(ub)LGHVVMGNNAVSPYQQVIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDSKLGHVVMGNNAVSPYQQVIEK 24 1 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 45035800.0 9521800.0 10748000.0 24766000.0 True False 9219535.670969797 15039732.450079551 18279041.63592576 1.0 1.631289577569098 1.9826423247628693 23.136262662488782 -9.611071807668203 0.14255532531226564 5.573737815394801e-20 2.5805836010971603 0.9998053248685876 0.0056724566151727775 1.0862783121100985 0.05912342609203421 0.74311748990004 0.3153659161462775 2.4486583392036827e-10 9.611071807668203 2.5805836010971603 IDSK(ub)LGHVVMGNNAVSPYQQVIEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDSKLGHVVMGNNAVSPYQQVIEK 24 1 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 28416200.0 4229200.0 10165000.0 14022000.0 True False 5792849.529832613 9715876.688840134 10710292.3921549 1.0 1.6772188952611857 1.8488815110763597 22.465841760592543 -11.133526875722657 0.25640752190408617 2.9859144563145986e-09 1.925985778873281 0.9992503908672318 0.010033539537357283 3.2031221414488753 0.13758765968219028 1.931540457678966 0.0759887050561032 7.353144901314137e-12 11.133526875722657 1.9259857758873666 IDSK(ub)LGHVVMGNNAVSPYQQVIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IDSKLGHVVMGNNAVSPYQQVIEK 24 1 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 53442000.0 11976800.0 18839100.0 22626100.0 True False 9959239.862202637 18737610.02903143 27357112.898733653 1.0 1.8814297364344554 2.746907723606449 23.247604202292198 -6.971349725544764 0.22361141274108692 0.6186412424273189 4.034238393340042 0.9999910822546799 0.0021297386478496367 0.07586713180547666 0.007443445951766053 0.023323746230869826 0.08706248850273106 1.0681943449078558e-07 6.971349725544764 3.4155971509127228 IDSLSAQLSQLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDSLSAQLSQLQK 13 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 107183000.0 26685000.0 24612000.0 55886000.0 False True 34984293.41790762 20939985.53682457 50103452.8163658 1.0 0.5985539077975459 1.4321699231666931 25.06020401786864 -6.775743155765375 1.5522353294872806 0.771430019157047 1.4379361035356502 0.7520824329843947 0.16948933466993973 0.2572630579688955 1.2239640794592568 0.08602387952910824 0.20373296407839056 1.6759337397726798e-07 6.775743155765375 0.6665060843786031 IDSLSAQLSQLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDSLSAQLSQLQK 13 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 65641100.0 15723000.0 5450100.0 44468000.0 False True 15223881.971335074 7626353.35189604 32820496.788595118 1.0 0.5009466945589595 2.155855966986119 23.859832945963063 -6.82584936153006 1.3464831318984551 0.7324884155651128 2.1966887113241476 0.8972885503540763 0.22213657172684878 0.1859911740883723 0.6609467643444978 0.1295883262228965 0.29830266215373613 1.4933122869157708e-07 6.82584936153006 1.4642002957590348 up IDSLSAQLSQLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDSLSAQLSQLQK 13 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 64742000.0 26685000.0 15854000.0 22203000.0 False True 36551165.63500977 15153517.857832914 16959108.685138747 1.0 0.41458371011069567 0.46398270453226853 25.12341407939153 -10.202878053185527 8.343201866605082 1.0000001253701776 0.4392832089204479 0.9942125184786432 0.02016705502324107 4.702690424914348e-08 4.49889012246903e-09 0.01952667142620181 0.006508889020588464 6.267898381122107e-11 10.202878053185527 -0.5607169164497297 IDSLSAQLSQLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDSLSAQLSQLQK 13 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 29447900.0 15723000.0 7923200.0 5801700.0 False True 13074371.14700187 7880516.148967944 7014808.645970055 1.0 0.6027453298031128 0.5365312462908509 23.64023822139734 -13.999999999999998 0.2521053415359417 3.792302838333341 0.5104357490701654 0.9995466851492808 0.004357609993140266 14.082425362088543 0.15887955579270932 19.938449974012048 0.030203872032896956 1.0000000000000041e-14 13.999999999999998 -3.2818670892631756 IDSLSAQLSQLQK(ub)QLAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDSLSAQLSQLQKQLAAK 18 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 22867000.0 9525400.0 10626000.0 2715600.0 True False 12487891.644104809 9040642.219823586 2434615.761874587 1.0 0.7239526476906473 0.19495811072511204 23.574026588607417 -7.181797892736829 0.4909332216570276 1.0117481294718547 2.3437172254999072e-11 0.9992582510327087 0.009097081006936273 0.08539890622650981 0.034894969687691284 0.010498385924854846 0.04663966767200148 6.57963962263254e-08 7.181797892736829 -1.0117481294484174 down IDSLSAQLSQLQK(ub)QLAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDSLSAQLSQLQKQLAAK 18 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 143344000.0 37000000.0 86518000.0 19826000.0 True False 35825455.25277603 121065088.58540961 14632975.83274909 1.0 3.3793035631006694 0.4084519158096453 25.094481701895027 -6.693471828123895 1.8543713498180057 2.4868102310126874 0.4183489130051272 0.3866170998355515 1.0055814347815506 0.4092341853965751 2.7310639178184957 0.43341377302317535 1.1236042195247304 2.0254809917520883e-07 6.693471828123895 -2.06846131800756 IDSLSAQLSQLQK(ub)QLAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDSLSAQLSQLQKQLAAK 18 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 76249000.0 33609000.0 22577000.0 20063000.0 True False 50987310.14702171 18547957.955093894 16097539.256074706 1.0 0.3637759650707388 0.31571658143286074 25.60363489431543 -13.999999999999998 0.36642117993133594 9.665270457448683 0.310451675268264 0.999784711753078 0.004575890140314124 22.407699790185575 0.1961682860924797 152.27784615702515 0.013584148714525915 1.0000000000000041e-14 13.999999999999998 -9.35481878218042 IDSLSAQLSQLQK(ub)QLAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDSLSAQLSQLQKQLAAK 18 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 60030400.0 9525400.0 16270000.0 34235000.0 True False 13047197.794256011 15551137.602304872 26149398.091957163 1.0 1.1919139916121462 2.004215656443053 23.63723665013031 -6.943578690634001 0.6253937403871797 0.9911334309726629 2.248429765165317 0.9985959745454566 0.016309585602990954 0.08617145876183975 0.04745684672998479 0.01634512859279925 0.06888760052437319 1.1387314342917024e-07 6.943578690634001 1.2572963341926542 up IDSLSAQLSQLQK(ub)QLAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDSLSAQLSQLQKQLAAK 18 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 86255600.0 37000000.0 39909000.0 9346600.0 True False 30767139.377922084 39694002.29568372 11300930.846204355 1.0 1.2901427658941664 0.3673052183172313 24.874886977329304 -6.8221823195078155 1.3623348717512522 1.1560481411929862 0.3461870343477012 0.8893524103101268 0.12816563301273165 0.19065383186230678 0.6946723546529306 0.07391651577400872 0.17028057836941465 1.5059747159697842e-07 6.8221823195078155 -0.809861106845285 down IDSLSAQLSQLQK(ub)QLAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDSLSAQLSQLQKQLAAK 18 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 67876100.0 33609000.0 25850000.0 8417100.0 True False 43507513.03243445 24411424.77602378 6885274.166739252 1.0 0.5610852718201863 0.15825483202421486 25.37476121640788 -7.810486509801301 0.3815640890280936 1.0588327774144475 7.86984804661779e-23 0.9983208876819206 0.014085680096122492 0.11332877369537868 0.06760257148186355 0.035470937498301505 0.07970219972024846 1.547082559191213e-08 7.810486509801301 -1.0588327774144475 down IDTIEIITDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDTIEIITDR 10 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 254276000.0 50608000.0 98818000.0 104850000.0 False True 66347578.08856909 84074739.58954708 94001127.79221915 1.0 1.2671862637896676 1.4167981786273287 25.983540467510352 -11.734164290928119 0.08699778942297766 5.6039211753783104e-18 1.8637285274350197 0.9999121987554825 0.0016154089132625075 5.042305860937719 0.06216823832269953 1.276827722518948 0.32185111707846054 1.844317593207958e-12 11.734164290928119 1.8637285274350197 IDTIEIITDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDTIEIITDR 10 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 233970000.0 74903000.0 44137000.0 114930000.0 False True 72525245.26482923 61761134.27141441 84826385.17390575 1.0 0.8515811845363751 1.169611834667478 26.111979933528357 -6.779818872207138 1.5367278119937497 0.9159413470297115 1.1721100126983413 0.7666954621424666 0.06275901686382823 0.2508577343880515 1.1701352367552982 0.03216739353076467 0.07590824609056648 1.6602792026859045e-07 6.779818872207138 0.2561686656686297 IDTIEIITDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDTIEIITDR 10 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 361155000.0 18166000.0 301720000.0 41269000.0 False True 27559150.11249359 247875708.65088028 33112164.06115476 1.0 8.994316139615242 1.2014943830268474 24.716028062145007 -6.640299166877671 2.0441629217135224 6.226815501121917 1.2343867233007435 0.15552791740321648 3.4203133201278573 0.5325658809390917 4.2538569845456555 1.3626683507493156 3.7856393529098584 2.289290115518633e-07 6.640299166877671 -4.992428777821173 IDTIEIITDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDTIEIITDR 10 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 247157000.0 50608000.0 98693000.0 97856000.0 False True 69319145.22977597 94332416.92589273 74744428.2075816 1.0 1.3608421831112298 1.0782652896226885 26.046750529033243 -10.059421512956357 6.699374351340601 0.9999998902885643 1.2195537363669595 0.44595563136211713 0.11536153369128754 1.88955835405359e-07 2.658378047953077e-08 0.11169838128531048 0.03723277489827499 8.721245000861247e-11 10.059421512956357 0.21955384607839523 IDTIEIITDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDTIEIITDR 10 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 149680000.0 74903000.0 35295000.0 39482000.0 False True 62285163.26552695 35104858.82949103 47737503.6558578 1.0 0.5636151049301424 0.7664345913704803 25.892385208962633 -10.072292334881128 4.858130917456314 1.000009421275006 0.6650248481484418 0.7843438166294932 0.08280070862576343 21696025.106459174 44982054.31416012 1528.3935064880927 0.028344885135553763 8.466573152872161e-11 10.072292334881128 -0.33498457312656416 IDTIEIITDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDTIEIITDR 10 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 103983000.0 18166000.0 56698000.0 29119000.0 False True 23516245.10539453 53542706.458452456 23819640.786171094 1.0 2.2768391049883205 1.0129015359134423 24.487154384237456 -6.6438450519392545 2.030457510211178 1.8325566444029366 1.0181876789891307 0.16942147838362298 0.5458048435578627 0.5238430150022728 4.1321715317297265 0.21854112051471175 0.60446228622585 2.2706748412367156e-07 6.6438450519392545 -0.814368965413806 IDTTSFLANLK(ub)LHTEDSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDTTSFLANLKLHTEDSR 18 1 E9PPJ1;Q8NG31-3;Q8NG31-4;Q8NG31-2;Q8NG31 E9PPJ1 CASC5 Protein CASC5 1 19661600.0 6025100.0 4011300.0 9625200.0 True False 7799610.72247674 3788067.62878391 7873512.362892058 1.0 0.4856739347090161 1.009475042158495 22.894970690380212 -10.769668698157117 11.546834763298062 1.0005527589228669 0.7475744884337556 0.23643776372917846 0.213840906659328 0.003048933721315575 6.081877878106258e-05 0.20745919237527802 0.069016855852456 1.6995396530594397e-11 10.769668698157117 -0.25297827048911126 IDVAFVDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDVAFVDR 8 0 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 5358100.0 1026200.0 1502500.0 2829400.0 False True 1345358.1377349356 1278332.8566991286 2536640.829521268 1.0 0.9501803429467103 1.8854762597206967 20.359558842297012 -6.894320874536169 0.9964398097883101 0.9548263099333006 1.9730846599388527 0.9835238733662109 0.055148547913735343 0.11570851738827469 0.20191444128708214 0.04191154410195117 0.10625299936053492 1.2754960718919829e-07 6.894320874536169 1.018258350005552 IDVDAPDIDIHGPDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDVDAPDIDIHGPDAK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 12228700.0 4223500.0 1266200.0 6739000.0 False True 4089427.3043270125 1771800.2631457704 4973853.734333518 1.0 0.43326366537217403 1.2162714639946517 21.963467387293598 -6.712555540926726 1.7861313289210814 0.652491902333156 1.2145697324249665 0.4771848514887276 0.23872705266007238 0.36997758840450856 2.3023942715425845 0.10630044354114132 0.2692158913932998 1.9384047219591606e-07 6.712555540926726 0.5620778300918104 IDVDAPDIDIHGPDAKLK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDVDAPDIDIHGPDAKLK 18 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 5183740.0 2012000.0 2283000.0 888740.0 True False 1673067.1467129542 2270701.025859983 1074571.4249305266 1.0 1.357208543794067 0.6422763288620653 20.674063916843796 -6.7708599921459625 1.571205480043199 1.2046595143864216 0.6381276708560226 0.7338307704791538 0.15058031549819353 0.2650375238418191 1.2913995377392282 0.07553679383215793 0.17966421189660767 1.694884109118148e-07 6.7708599921459625 -0.566531843530399 IDVIK(ub)QADYVPSDQDLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDVIKQADYVPSDQDLLR 18 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;A0A590UJQ9;S4R3E3;A0A590UJ22;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;A0A590UK28;P63092-3;A0A590UJF0;A0A590UJG5;A0A590UKA4 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 134722700.0 5115900.0 8994100.0 120612700.0 True False 6706994.4424460735 7652215.338727207 108132854.80271415 1.0 1.140930621665523 16.122401133715204 22.67723497593048 -6.908955779051551 0.9027880277355694 0.5207143799729852 18.01606636744852 0.9905225818180685 0.6907889782705351 0.10511219412713135 0.14253038572679994 0.5626595872285493 1.54223999028724 1.233230397434239e-07 6.908955779051551 17.495351987475534 up IDVIK(ub)QADYVPSDQDLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDVIKQADYVPSDQDLLR 18 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;A0A590UJQ9;S4R3E3;A0A590UJ22;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;A0A590UK28;P63092-3;A0A590UJF0;A0A590UJG5;A0A590UKA4 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 155208100.0 5954100.0 14454000.0 134800000.0 True False 5765090.354609568 20225557.576614235 99491836.08668305 1.0 3.508281107934861 17.25763690887044 22.45891178832449 -6.937776508448211 0.6799337499982424 0.8381245594764355 20.73482947382324 0.9978579314554334 0.33075593825930416 0.08879580980380805 0.05933963200131063 0.31678046023470796 1.1954348260606242 1.154046987215115e-07 6.937776508448211 19.896704914346806 IDVIK(ub)QADYVPSDQDLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDVIKQADYVPSDQDLLR 18 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;A0A590UJQ9;S4R3E3;A0A590UJ22;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;A0A590UK28;P63092-3;A0A590UJF0;A0A590UJG5;A0A590UKA4 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 234958500.0 12358000.0 145751000.0 76849500.0 True False 18747989.490817767 119740595.29223923 61660162.64066766 1.0 6.386849926008588 3.288894666324998 24.160232555438885 -9.454739122604574 9.446230513818298 0.9999991638430008 4.8378722961668 0.6717330177486873 1.2647349386994788 0.0 0.0 1.2245743387373806 0.40819144624579345 3.5096263123198205e-10 9.454739122604574 3.8378731323237996 IDVIK(ub)QADYVPSDQDLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDVIKQADYVPSDQDLLR 18 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;A0A590UJQ9;S4R3E3;A0A590UJ22;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;A0A590UK28;P63092-3;A0A590UJF0;A0A590UJG5;A0A590UKA4 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 108860100.0 5115900.0 9871300.0 93872900.0 True False 7007386.481999114 9435153.325976154 71702054.39306214 1.0 1.3464582480520513 10.232353328484674 22.740445037453373 -6.915126463074626 0.8600965756036444 0.7674447126629623 11.516113231879574 0.9927165676837092 0.36465827455672484 0.10112468060716426 0.12110187017615298 0.3063354849017361 0.8789003667035524 1.2158319085809746e-07 6.915126463074626 10.748668519216611 up IDVIK(ub)QADYVPSDQDLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDVIKQADYVPSDQDLLR 18 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;A0A590UJQ9;S4R3E3;A0A590UJ22;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;A0A590UK28;P63092-3;A0A590UJF0;A0A590UJG5;A0A590UKA4 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 90279900.0 5954100.0 12946000.0 71379800.0 True False 4951097.961353678 12876257.32842019 86304986.15709431 1.0 2.6006872473393146 17.431484254756633 22.239317063758765 -6.927471334571904 0.7672609464082657 0.7520571031640844 20.28899663513423 0.9960175660082532 0.46683119126525424 0.09397222803419211 0.0842686151709954 0.41907545789541456 1.3610666903645803 1.1817583114403871e-07 6.927471334571904 19.536939531970145 IDVIK(ub)QADYVPSDQDLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDVIKQADYVPSDQDLLR 18 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;A0A590UJQ9;S4R3E3;A0A590UJ22;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;A0A590UK28;P63092-3;A0A590UJF0;A0A590UJG5;A0A590UKA4 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 136984000.0 12358000.0 74231000.0 50395000.0 True False 15997674.612598559 70099979.59570672 41223627.09636627 1.0 4.381885573575879 2.576851204605803 23.931358877531334 -9.8702827531844 7.987976934297922 0.9999999976547685 3.4793683890908413 0.7155574316310143 0.7369021953605522 2.8006532891445694e-08 7.986013703919555e-09 0.7135024772877666 0.23783416086792505 1.3480849082491537e-10 9.8702827531844 2.479368391436073 IDVSIEAASGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDVSIEAASGGK 12 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 7053400.0 0.0 0.0 7053400.0 False True 0.0 0.0 6323581.828990359 0.0 IDVSIEAASGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDVSIEAASGGK 12 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 8366200.0 3949500.0 4416700.0 0.0 False True 3824125.2843469973 6180311.3427862255 0.0 1.0 1.616137255775491 0.0 21.86669835837121 -6.81880432615886 1.480161536968954 1.337503990620754 1.0970210889601125e-18 0.8413018317749963 0.2652980850947133 0.20709985262661573 0.9084712229575231 0.14305139045998888 0.31458487307150834 1.5177340371076655e-07 6.81880432615886 -1.337503990620754 IDVSIEAASGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDVSIEAASGGK 12 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 14862800.0 0.0 5468500.0 9394300.0 False True 0.0 5226883.588088759 7175559.821681702 0.0 IDVSIEAASGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDVSIEAASGGK 12 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 10371300.0 3949500.0 2791700.0 3630100.0 False True 3284184.2425163044 2776660.557990933 4389137.126313999 1.0 0.8454643080144272 1.3364466796634689 21.647103633805486 -6.822085480323187 1.3627398125307348 0.9168767176960833 1.3476604289083076 0.8891330903219364 0.0682506501858968 0.19078320514857616 0.6955824681117053 0.039350226096422934 0.09065333891140102 1.5063105563506624e-07 6.822085480323187 0.43078371121222436 IDVSIEAASGGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDVSIEAASGGK 12 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 8791700.0 0.0 0.0 8791700.0 False True 0.0 0.0 7191700.810459847 0.0 IDVSVAAGHTDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDVSVAAGHTDR 12 0 A0A087WT45;Q4V328-4;Q4V328 A0A087WT45 GRIPAP1 GRIP1-associated protein 1 0 3101820.0 825450.0 877670.0 1398700.0 False True 1082172.9436691701 746725.0571308641 1253975.9412777955 1.0 0.6900237725395809 1.1587574320848544 20.045499646156113 -6.72836093822304 1.7290053807547991 0.8131198442220418 1.1584063406472107 0.5517303468237338 0.1303244426501118 0.339324128825275 1.9864938933416132 0.05974805071021632 0.1485480136349485 1.8691280792002687e-07 6.72836093822304 0.34528649642516895 IDVTAPDVSIEEPEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDVTAPDVSIEEPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 13534600.0 4243300.0 1928400.0 7362900.0 False True 4108598.764164984 2698420.1764731514 5434335.607734708 1.0 0.6567738373502549 1.322673719111426 21.970215016594512 -6.766598832478662 1.587327668313528 0.8022793104553653 1.3259594315815646 0.7174210978957198 0.1445346980038538 0.271972333509063 1.3518252057138456 0.07179263791930338 0.17144511701204979 1.7115956242343207e-07 6.766598832478662 0.5236801211261993 IDVVVNNAGILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDVVVNNAGILR 12 0 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ER27;A0A2R8YDT8;A0A2R8YF45 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 12486000.0 3090900.0 4625800.0 4769300.0 False True 4052199.8323181747 3935648.6712271767 4275818.586356042 1.0 0.9712375583845968 1.055184532671465 21.95027389104114 -6.814212749401008 1.3965593736131325 0.9843999834585061 1.056801489852001 0.8705613123094053 0.012531879561278667 0.20112960812460437 0.7722759636887713 0.007053803965662999 0.016289513494897493 1.5338653985600442e-07 6.814212749401008 0.07240150639349496 IDVVVNNAGILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDVVVNNAGILR 12 0 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ER27;A0A2R8YDT8;A0A2R8YF45 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 7676900.0 2135400.0 1846200.0 3695300.0 False True 2067612.8958588615 2583397.2878058106 2727390.073376261 1.0 1.2494588774233286 1.319100920118481 20.97953467494757 -13.290709205911067 0.18776893211878135 1.205865377169879e-13 1.3717723128946644 0.999470026250769 0.0031537454273197108 9.28753817154037 0.13261094204171095 3.447881711376832 0.04871753474518665 5.1202456123711924e-14 13.290709205911067 1.3717723128945438 IDVVVNNAGILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDVVVNNAGILR 12 0 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ER27;A0A2R8YDT8;A0A2R8YF45 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 16288600.0 2656100.0 9263400.0 4369100.0 False True 4029497.8869203017 7610273.89472546 3505545.469955445 1.0 1.888640745892512 0.8699707924737721 21.942168645997658 -6.676171192046518 1.9157461869161594 1.5641786796843253 0.8739775108914752 0.3066120376832544 0.3769468680781488 0.44706534667892495 3.1689032890084627 0.15808883733105825 0.4189660189090645 2.1077971257173927e-07 6.676171192046518 -0.6902011687928501 IDVVVNNAGILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDVVVNNAGILR 12 0 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ER27;A0A2R8YDT8;A0A2R8YF45 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 11329900.0 3090900.0 3268000.0 4971000.0 False True 4233689.258431761 3123608.954169163 3796952.1809586426 1.0 0.7377983511539549 0.8968424343843096 22.01348395256403 -10.321324079740315 5.392862978137948 1.0000399652187693 0.8173203930040347 0.637559413195364 0.06492947508720727 3.1206268689307266e-05 3.927246404368018e-06 0.06288143165919786 0.02095589797422532 4.7717306412217923e-11 10.321324079740315 -0.18271957221473456 IDVVVNNAGILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDVVVNNAGILR 12 0 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ER27;A0A2R8YDT8;A0A2R8YF45 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 5460800.0 2135400.0 1524400.0 1801000.0 False True 1775679.714259859 1516187.7546302911 2177580.773116857 1.0 0.8538633079233382 1.2263364590074843 20.759939950381845 -6.80033415433049 1.4550339442351616 0.9194036960479139 1.2314918284844412 0.8329941020366403 0.06262032730149437 0.2202899321164058 0.9207926663981798 0.0338599567014188 0.0787126962166392 1.5836742148865648e-07 6.80033415433049 0.3120881324365272 IDVVVNNAGILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDVVVNNAGILR 12 0 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ER27;A0A2R8YDT8;A0A2R8YF45 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 8060400.0 2656100.0 3659000.0 1745300.0 False True 3438373.809558428 3455373.4334804956 1427673.308290268 1.0 1.0049440883579355 0.4152175962722379 21.713294968090107 -6.905010163517045 0.9290596283904705 1.0212635305341355 0.3466140340801675 0.9888980446386321 0.029169657584353 0.10781051598277139 0.15735521053968846 0.023307392500708846 0.06231696556650682 1.2444854875296695e-07 6.905010163517045 -0.674649496453968 down IDVYGFSALWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDVYGFSALWK 11 0 Q9UBV8 Q9UBV8 PEF1 Peflin 0 6911900.0 2114700.0 3329200.0 1468000.0 False True 2772392.17878393 2832496.3371199574 1316105.4420503348 1.0 1.0216795296120016 0.47471835049961275 21.40269992289114 -6.8976708599395895 0.9758852527501742 1.0242166289195809 0.4199475988421477 0.985371166700777 0.030586366162168543 0.1131397284093864 0.18725106247935988 0.023606186582382394 0.060731402946262045 1.265695220302746e-07 6.8976708599395895 -0.6042690300774332 down IDVYGFSALWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDVYGFSALWK 11 0 Q9UBV8 Q9UBV8 PEF1 Peflin 0 15699900.0 5668800.0 4150100.0 5881000.0 False True 5488847.046944239 5807256.572485595 4340589.673781781 1.0 1.0580102748023597 0.7908017178577207 22.388071706834943 -6.8498553876695105 1.23578922011045 1.0309524426414525 0.7801495436733374 0.9400953393444966 0.028088097041961097 0.15761553102218473 0.4632735018594838 0.017786037545290647 0.04115414842838789 1.4130079727946847e-07 6.8498553876695105 -0.25080289896811503 IDVYGFSALWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDVYGFSALWK 11 0 Q9UBV8 Q9UBV8 PEF1 Peflin 0 9455600.0 0.0 3566100.0 5889500.0 False True 0.0 2929701.5929335295 4725437.743540447 0.0 IDVYGFSALWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDVYGFSALWK 11 0 Q9UBV8 Q9UBV8 PEF1 Peflin 0 16543900.0 2114700.0 6905300.0 7523900.0 False True 2896561.7376187025 6600201.013226543 5746909.779584534 1.0 2.278632948680958 1.9840453268947533 21.465909984414033 -10.050772563885712 4.834466795128153 0.9999708536558405 2.1313391378041757 0.9516091511464387 0.12026489304228492 7826389.5078022415 16270928.49318219 1502.719358695409 0.04116987540841901 8.89666906440224e-11 10.050772563885712 1.1313682841483352 IDVYGFSALWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDVYGFSALWK 11 0 Q9UBV8 Q9UBV8 PEF1 Peflin 0 11375200.0 5668800.0 2197300.0 3509100.0 False True 4713858.37042067 2185462.7087700996 4242836.58575479 1.0 0.46362502583527265 0.9000772302321325 22.16847698226922 -10.010737377783414 7.100084865749313 1.0000000301149277 0.6818511280337052 0.41468357855074633 0.1781808663142032 8.500193876833154e-08 1.1948607899273726e-08 0.17252289995742714 0.05750762732064319 9.755794020023947e-11 10.010737377783414 -0.3181489020812225 IDVYGFSALWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDVYGFSALWK 11 0 Q9UBV8 Q9UBV8 PEF1 Peflin 0 12259900.0 0.0 7049500.0 5210400.0 False True 0.0 6657189.127991464 4262160.663218715 0.0 IDWNK(ub)ILSYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDWNKILSYK 10 1 P52907;P47755 P52907;P47755 CAPZA1;CAPZA2 F-actin-capping protein subunit alpha-1;F-actin-capping protein subunit alpha-2 1 5659100.0 2180000.0 1869200.0 1609900.0 True False 2110797.093271669 2615581.3077492253 1188218.894035246 1.0 1.2391438836478388 0.5629242610873336 21.00935647126828 -6.811125994359356 1.4099064759120616 1.1301563711607412 0.5507982122301402 0.8627276849690212 0.10373327990270449 0.20526419500113569 0.8039975855980935 0.05785026580677087 0.13374557190190678 1.5448062065709562e-07 6.811125994359356 -0.5793581589306009 IDWNK(ub)ILSYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDWNKILSYK 10 1 P52907;P47755 P52907;P47755 CAPZA1;CAPZA2 F-actin-capping protein subunit alpha-1;F-actin-capping protein subunit alpha-2 1 5323400.0 2180000.0 2050500.0 1092900.0 True False 1812766.5903748693 2039453.5495076182 1321420.3370013414 1.0 1.1250502741700856 0.7289522788083156 20.789761746702556 -6.821843584406339 1.3640843338053035 1.0672767162090577 0.7199726892309345 0.8885292198378719 0.05519822402352592 0.19109644579529086 0.6982157124174267 0.03179626279670373 0.07324425278118622 1.5071497838373158e-07 6.821843584406339 -0.34730402697812324 IDYGEYMDK(ub)NNVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDYGEYMDKNNVR 13 1 Q04837;A0A0G2JLD8;E7EUY5 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 1 7094300.0 2640800.0 1999400.0 2454100.0 True False 3462114.3735435754 1701097.3136001576 2200173.2733894615 1.0 0.4913463652730325 0.6354998812871453 21.723221955328132 -10.576573755496534 9.690658918912552 1.000034417666083 0.5634231232801097 0.9244115160732408 0.05885042647711665 4.37643120504521e-05 1.9122949413747473e-06 0.05698613908820107 0.018993893471923068 2.6511008228119615e-11 10.576573755496534 -0.43661129438597324 IDYGEYMDK(ub)NNVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDYGEYMDKNNVR 13 1 Q04837;A0A0G2JLD8;E7EUY5 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 1 13379200.0 3887600.0 2099600.0 7392000.0 True False 3764190.265964653 2937981.229269359 5455813.444753426 1.0 0.7805081628934183 1.4493989568179437 21.843908122158467 -6.8182991237635555 1.3791312485336977 0.881484913605793 1.4634849629279256 0.8804366037962161 0.09626442997497973 0.1957074101524291 0.7318662034378725 0.05485625305170383 0.12650106896573265 1.5195006011618525e-07 6.8182991237635555 0.5820000493221327 IDYGEYMDK(ub)NNVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDYGEYMDKNNVR 13 1 Q04837;A0A0G2JLD8;E7EUY5 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 1 34706300.0 4428500.0 5719800.0 24558000.0 True False 6718358.266716829 4699057.000998623 19704100.53584621 1.0 0.6994353105993243 2.9328743353062268 22.679677300864732 -6.872960847031686 1.1183830619787585 0.826572790352575 3.071211732623762 0.967546552891734 0.17828313986397765 0.13404413712376123 0.3115680943958116 0.12348536616561157 0.2939404867054733 1.3397974687978363e-07 6.872960847031686 2.244638942271187 up IDYGEYMDK(ub)NNVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDYGEYMDKNNVR 13 1 Q04837;A0A0G2JLD8;E7EUY5 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 1 9298200.0 2640800.0 2637200.0 4020200.0 True False 3617175.1249366184 2520679.7839458133 3070711.558617969 1.0 0.6968641818219906 0.848925322262846 21.786432016851023 -10.178671389192951 4.931027407537801 1.0000202410490582 0.7728947520419341 0.7483711422384682 0.062078700632639934 1.3815057466217076e-05 2.3011501495864903e-06 0.06011279666858525 0.02003581447512836 6.627177623129249e-11 10.178671389192951 -0.22712548900712404 IDYGEYMDK(ub)NNVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDYGEYMDKNNVR 13 1 Q04837;A0A0G2JLD8;E7EUY5 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 1 13085000.0 3887600.0 4989200.0 4208200.0 True False 3232711.6498813503 4962322.189321336 5088115.1634816 1.0 1.5350339673826052 1.5739464927743703 21.624313397592744 -11.55868742687065 0.4302993867962372 1.5662370351338034e-09 1.5750501617747676 0.9997438555586787 0.0041911217716016245 4.201338768310375 0.2143302397079372 3.9031882468767707 0.0091929769935885 2.7625654316775086e-12 11.55868742687065 1.5750501602085305 IDYGEYMDK(ub)NNVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IDYGEYMDKNNVR 13 1 Q04837;A0A0G2JLD8;E7EUY5 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 1 26351400.0 4428500.0 7151900.0 14771000.0 True False 5732780.548785629 6753890.477974627 12082829.563258793 1.0 1.1781177424287241 2.107673485917456 22.45080362295718 -6.938855341356415 0.6701356831465394 0.9893309091069041 2.350117338868212 0.9980099978270704 0.021664763078415156 0.08829286936776262 0.057018633143782034 0.02091034874939876 0.08041695786411625 1.1511837715534811e-07 6.938855341356415 1.360786429761308 up IDYIAGLDSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IDYIAGLDSR 10 0 P07741-2;P07741;H3BQB1;H3BQF1 P07741-2 APRT Adenine phosphoribosyltransferase 0 51221000.0 13805000.0 15641000.0 21775000.0 False True 18098488.68781015 13307423.76814049 19521931.8805491 1.0 0.7352781769620035 1.0786498374141968 24.10936589446839 -6.7008321812967795 1.828083501401495 0.8357483051771151 1.0776374335329297 0.42140496887675005 0.11172604013764026 0.3938156169095786 2.5592836155744814 0.04874871487218808 0.1252317641241407 1.9914427173377956e-07 6.7008321812967795 0.24188912835581466 IDYIAGLDSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IDYIAGLDSR 10 0 P07741-2;P07741;H3BQB1;H3BQF1 P07741-2 APRT Adenine phosphoribosyltransferase 0 28545200.0 7784000.0 3724200.0 17037000.0 False True 7536901.180746185 5211292.481446439 12574498.600955626 1.0 0.6914370185400918 1.6683910667528081 22.845540046385103 -6.82180598337531 1.3642490880790312 0.833987812249978 1.6905198744837817 0.888442168252138 0.13619218375187908 0.19114696258269015 0.6985799313257274 0.07844247588384444 0.1806975285617502 1.5072802778718193e-07 6.82180598337531 0.8565320622338037 IDYIAGLDSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IDYIAGLDSR 10 0 P07741-2;P07741;H3BQB1;H3BQF1 P07741-2 APRT Adenine phosphoribosyltransferase 0 48685100.0 3443100.0 40834000.0 4408000.0 False True 5223434.4243271295 33546853.66250181 3536756.8679049625 1.0 6.42237480885447 0.6770941454597775 22.31656726456395 -6.659223560778866 1.9753870978517765 4.492559244551295 0.7009760633111269 0.2323419840198624 2.3091577343176497 0.4863368408207675 3.6472677422614135 0.9446357269141955 2.56000823103804 2.191676440641744e-07 6.659223560778866 -3.791583181240168 IDYIAGLDSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IDYIAGLDSR 10 0 P07741-2;P07741;H3BQB1;H3BQF1 P07741-2 APRT Adenine phosphoribosyltransferase 0 39421000.0 13805000.0 12738000.0 12878000.0 False True 18909081.566097397 12175193.04106694 9836481.630735327 1.0 0.6438807193521325 0.5201988048098233 24.17257595599128 -13.999999999999998 0.1474925575463284 2.715684251635286 0.38012170690545394 0.999574823400241 0.00419397152862713 11.949213586571329 0.12081674214991732 5.880261475457492 0.12596387111653015 1.0000000000000041e-14 13.999999999999998 -2.335562544729832 IDYIAGLDSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IDYIAGLDSR 10 0 P07741-2;P07741;H3BQB1;H3BQF1 P07741-2 APRT Adenine phosphoribosyltransferase 0 17777400.0 7784000.0 5556000.0 4437400.0 False True 6472740.889668803 5526068.725220344 5365239.823780533 1.0 0.8537447766587644 0.8288976671913498 22.62594532181938 -13.99999999999997 0.24939437613989018 2.0140406926320145 0.8188493225404094 0.999541549011387 0.0016162676593725726 13.97399614996634 0.15802564669931116 7.0962760101991975 0.011505472827359371 1.0000000000000696e-14 13.99999999999997 -1.195191370091605 IEALQNHENESVYK(ub)ASLSLIEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEALQNHENESVYKASLSLIEK 22 1 P52292 P52292 KPNA2 Importin subunit alpha-1 1 16709800.0 6371300.0 7982100.0 2356400.0 True False 8352835.999756962 6791201.793982105 2112582.332184884 1.0 0.813041438163003 0.25291797088394324 22.993834681656445 -6.951481561872854 0.542343292175389 1.0081217474348279 0.031867463470859274 0.9993124267482821 0.008323375297152595 0.08289639085499272 0.0335432320299218 0.009125588680403484 0.04640377976943547 1.1181972970415984e-07 6.951481561872854 -0.9762542839639686 down IEALQNHENESVYK(ub)ASLSLIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEALQNHENESVYKASLSLIEK 22 1 P52292 P52292 KPNA2 Importin subunit alpha-1 1 50248000.0 11193000.0 22297000.0 16758000.0 True False 16980599.3179093 18317926.142743856 13445773.954707678 1.0 1.078756161652321 0.7918315309711437 24.017384042873818 -6.833524605961317 1.3119609066489037 1.041992136050292 0.783532828403013 0.9127583870278368 0.03575205846756898 0.17650593607367962 0.5928939295591321 0.021387172451348226 0.04922304613916636 1.4671529595985674e-07 6.833524605961317 -0.258459307647279 IEALQNHENESVYK(ub)ASLSLIEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEALQNHENESVYKASLSLIEK 22 1 P52292 P52292 KPNA2 Importin subunit alpha-1 1 18431100.0 6371300.0 6192600.0 5867200.0 True False 8726941.787908467 5918990.455810274 4481488.198777015 1.0 0.6782433754756192 0.5135233289840778 23.057044743179336 -13.99999999999999 0.08573506083720249 2.680784658822376 0.06986026932256993 0.9998619667881469 0.0023735112326971897 12.202972705188053 0.08400332976922795 3.796778635444312 0.40028202140307106 1.0000000000000246e-14 13.99999999999999 -2.610924389499806 IEALQNHENESVYK(ub)ASLSLIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEALQNHENESVYKASLSLIEK 22 1 P52292 P52292 KPNA2 Importin subunit alpha-1 1 44794400.0 15154000.0 23009000.0 6631400.0 True False 12601222.436027868 22885045.95007109 8017995.079870708 1.0 1.8160972926436865 0.6362870840964319 23.58706035959145 -6.720625083336173 1.7569831937234708 1.4961761553324082 0.6380556087129364 0.5154621669805635 0.3433917311051648 0.35412628322026196 2.136758686764664 0.15516174952213707 0.38924012400044056 1.9027201466598394e-07 6.720625083336173 -0.8581205466194718 IEAMDPATVEQQEHWFEK(ub)ALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEAMDPATVEQQEHWFEKALR 21 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 18103000.0 4113200.0 6692000.0 7297800.0 True False 3982628.717451846 9364150.498318972 5386287.250692851 1.0 2.351248675852043 1.3524452397709545 21.925289559330512 -10.128478009627758 4.768190714475361 0.9999415250524087 1.851846957817271 0.49234555860590834 0.40775979531467543 0.00025808729170723486 4.717355694101032e-05 0.39483914380445334 0.13160390803865102 7.439127297542973e-11 10.128478009627758 0.8519054327648622 IEAMDPATVEQQEHWFEK(ub)ALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEAMDPATVEQQEHWFEKALR 21 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 51780400.0 9304400.0 20676000.0 21800000.0 True False 14115455.042754896 16986206.25767466 17491220.44472056 1.0 1.2033764555392954 1.2391538488657055 23.750772302198158 -13.359349607968184 0.25273178044899314 4.957163491202749e-11 1.2534843178440396 0.9995104477585026 0.002330353234529215 10.263107855592864 0.1563935438139676 5.188225007626098 0.016271876538684886 4.371700406719198e-14 13.359349607968184 1.253484317794468 IEAMDPATVEQQEHWFEK(ub)ALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEAMDPATVEQQEHWFEKALR 21 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 5518700.0 1835400.0 1071800.0 2611500.0 True False 2513996.979820009 1024444.3320313685 1994717.485530777 1.0 0.40749624611908414 0.7934446626398055 21.261551485907848 -9.934658263848696 5.528719252026933 1.0000005147229525 0.6004704543785517 0.5882777090734282 0.1575627812551026 9.997458572945535e-07 1.924340050309189e-07 0.15255970244271 0.05085316898145148 1.1623628902033432e-10 9.934658263848696 -0.39953006034440075 IEAMDPATVEQQEHWFEK(ub)ALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEAMDPATVEQQEHWFEKALR 21 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 17854800.0 4113200.0 6199000.0 7542600.0 True False 3420308.045655921 6165604.75659484 9119722.786957918 1.0 1.8026460407347453 2.6663454476098236 21.70569483476479 -6.9701907312972855 0.25358780891319305 0.7377206754212223 3.7566837042085863 0.999983832780812 0.002735919131762391 0.0762408587396219 0.008808366039410499 0.018804779341369246 0.08230090346944943 1.0710488240212012e-07 6.9701907312972855 3.018963028787364 IEAMDPATVEQQEHWFEK(ub)ALR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IEAMDPATVEQQEHWFEKALR 21 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 67671200.0 14216000.0 28371300.0 25083900.0 True False 18402892.239254024 26792412.214622952 20518887.582548734 1.0 1.455880514122328 1.11498167330357 24.13342918545701 -10.269364599742547 5.517302249034692 0.9999734319505994 1.2854310937129563 0.48313435271388083 0.13917136898540572 4.548664563619022e-05 6.023586895217511e-06 0.13476462593266816 0.04491736619577523 5.37818082860894e-11 10.269364599742547 0.2854576617623569 IEASLQHEITR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEASLQHEITR 11 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;E7ERV5;Q9UES5;O95317 G3V394 MYO5A Unconventional myosin-Va 0 6490300.0 1783400.0 1911700.0 2795200.0 False True 2338054.670470166 1626481.8117482373 2505979.517451704 1.0 0.6956560222012104 1.0718224638210745 21.156877233964508 -6.6914284366889865 1.8611556037383676 0.8094545778681375 1.070552139272299 0.3772131230643496 0.1286785420925453 0.4136002557442689 2.7787484566061953 0.05528528564553095 0.14371783591987086 2.0350335022920253e-07 6.6914284366889865 0.2610975614041615 IEASLQHEITR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEASLQHEITR 11 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;E7ERV5;Q9UES5;O95317 G3V394 MYO5A Unconventional myosin-Va 0 3380890.0 904110.0 611080.0 1865700.0 False True 875409.5229347929 855087.4307401018 1377017.2001997384 1.0 0.9767856167173489 1.5729977389134582 19.73959855251484 -6.897841558866796 0.9748302233192548 0.9737214079272346 1.6329038832010345 0.9854605655761376 0.03324961501840974 0.11301190675651861 0.1865251508739451 0.025681838091356424 0.0661234822571468 1.2651978380628402e-07 6.897841558866796 0.6591824752737999 IEASLQHEITR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEASLQHEITR 11 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;E7ERV5;Q9UES5;O95317 G3V394 MYO5A Unconventional myosin-Va 0 5285200.0 1783400.0 1477700.0 2024100.0 False True 2442771.1745728445 1412410.3278995622 1546049.2676480364 1.0 0.5782000142303724 0.6329079382224111 21.2200872954874 -10.140526713488795 5.2120371406374835 1.000013073169492 0.6055539762264519 0.9857778371545818 0.022334416445699865 3.3929822770909365e-06 5.595027441498419e-07 0.021625921867033476 0.007208401911626356 7.2355789480666e-11 10.140526713488795 -0.39445909694304016 IEASLQHEITR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEASLQHEITR 11 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;E7ERV5;Q9UES5;O95317 G3V394 MYO5A Unconventional myosin-Va 0 5394000.0 1359400.0 2561500.0 1473100.0 False True 1759770.0977801029 2418950.2732605333 1205010.915282413 1.0 1.374583121006526 0.6847547397256596 20.74695553201777 -6.759218723545278 1.6152306948933748 1.2177855982309231 0.6823146028061441 0.6878605921637873 0.15753412417127116 0.2842212175300632 1.4612663012088645 0.07695616516134134 0.18509404694427178 1.7409298687977717e-07 6.759218723545278 -0.535470995424779 IECEIK(ub)INHEGEVNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IECEIKINHEGEVNR 15 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 75990000.0 9486000.0 23591000.0 42913000.0 True False 14390955.51949323 19381001.73267573 34431226.740563944 1.0 1.346748776092265 2.3925601530715053 23.77865905041541 -6.951330943374723 0.544039471776998 0.9849989166652786 2.8029408069416704 0.9993016113114942 0.015642338898890266 0.08295573258915806 0.03378481292434296 0.017110914362711484 0.08666578990784682 1.1185851684356162e-07 6.951330943374723 1.8179418902763917 up IECEIK(ub)INHEGEVNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IECEIKINHEGEVNR 15 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 92545000.0 9486000.0 18851000.0 64208000.0 True False 12279813.997014884 17801925.27863922 52522802.829715 1.0 1.4496901404994174 4.2771659931072925 23.54978537250786 -6.93485306415593 0.7058277968342932 0.9637518789221321 4.936530373626342 0.9974088835997494 0.07383697091347821 0.09019539722467008 0.0659035951301906 0.06932898100239798 0.24936596141861087 1.161841635885098e-07 6.93485306415593 3.9727784947042095 up IEDEKKDEEK(ub)EDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEDEKKDEEKEDPK 14 3 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 181139400.0 88186000.0 58464000.0 34489400.0 True False 115612699.99443893 49741399.09088709 30920767.73368589 1.0 0.43024165245928603 0.2674513071243315 26.784724644935903 -13.999999999999917 0.17569393253496104 3.9186403088421837 0.13222259988445964 0.9995039690897469 0.0069948596893271466 12.152045421472822 0.132828688435048 12.097065804431347 0.12614374999769357 1.0000000000001922e-14 13.999999999999917 -3.7864177089577242 IEDEKKDEEK(ub)EDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEDEKKDEEKEDPK 14 3 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 312631000.0 125154000.0 117163000.0 70314000.0 True False 121181054.77583615 163946796.8969736 51896654.025215365 1.0 1.3529078221034354 0.42825715720345175 26.852588927238394 -6.803262422485258 1.442560386516526 1.1939153894574537 0.4144406868951034 0.8415340617931615 0.15166553399001484 0.21613036370054597 0.887571908267634 0.0826978351033497 0.19195496703157117 1.57303207244586e-07 6.803262422485258 -0.7794747025623503 down IEDEKKDEEK(ub)EDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEDEKKDEEKEDPK 14 3 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 206747000.0 88186000.0 66061000.0 52500000.0 True False 120790747.33704227 63142206.58548632 40100581.27144002 1.0 0.5227404248878492 0.33198388250341243 26.847934706458794 -13.999999999999998 0.12648103758810952 3.2681526333755158 0.052507785836264045 0.9996618254610455 0.005166584662289072 11.943594586379632 0.11023313045923117 6.75756867173352 0.2482686467750359 1.0000000000000041e-14 13.999999999999998 -3.215644847539252 IEDEKKDEEK(ub)EDPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEDEKKDEEKEDPK 14 3 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 282776000.0 125154000.0 133754000.0 23868000.0 True False 104071096.26228288 133033440.65390964 28858688.44683689 1.0 1.278293834040482 0.2772978231545329 26.63299420267267 -6.832528902871969 1.316602190485472 1.1484579164963091 0.2489483266838744 0.9108378581505039 0.12596933995298276 0.17770710554030156 0.6015606098740384 0.07510274172394926 0.17282891867575145 1.4705205470613206e-07 6.832528902871969 -0.8995095898124348 down IEDGNDFGVAIQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEDGNDFGVAIQEK 14 0 A0A087X1Z3;Q9UL46;H0YM70;H0YKU2 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 0 13697800.0 1561500.0 5851700.0 6284600.0 False True 2047141.6215875095 4978649.169747948 5634329.878140012 1.0 2.4320003644335677 2.7522912038546328 20.965179481013532 -10.231626402359806 0.3375938462236322 2.922304875063526e-14 2.824928914291032 0.9989731000218166 0.02441368879703439 1.6573498364504673 0.15619726529482783 1.621226110407173 0.09896601448800091 5.866426011552438e-11 10.231626402359806 2.824928914291003 IEDGNDFGVAIQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEDGNDFGVAIQEK 14 0 A0A087X1Z3;Q9UL46;H0YM70;H0YKU2 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 0 5672100.0 2792400.0 1453500.0 1426200.0 False True 2322004.324294857 1445669.70700284 1724411.8259962606 1.0 0.6225956135727089 0.742639368908121 21.14693922827741 -10.76206012063644 10.234511292579475 1.001165157423231 0.6826174912404153 0.9031027195588599 0.04900765789654423 0.0013067186087932124 3.0379575083356947e-05 0.047589797924749364 0.015817153572495524 1.7295769123265112e-11 10.76206012063644 -0.3185476661828157 IEDGNDFGVAIQEK(ub)VLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEDGNDFGVAIQEKVLER 18 1 A0A087X1Z3;Q9UL46;H0YM70;H0YKU2 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 1 18158800.0 5319100.0 7381000.0 5458700.0 True False 6973391.6102376785 6279783.570912652 4893886.087547796 1.0 0.9005350512214549 0.7017942431862069 22.733429071784066 -6.960063540081415 0.43453903250790354 1.007524575176788 0.5871259592237222 0.9997725423478653 0.0018696748185830013 0.07967845184983091 0.021047653563578076 0.0026036225253669777 0.0164849917286876 1.0963177860518846e-07 6.960063540081415 -0.4203986159530658 IEDGNDFGVAIQEK(ub)VLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEDGNDFGVAIQEKVLER 18 1 A0A087X1Z3;Q9UL46;H0YM70;H0YKU2 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 1 61181000.0 17224000.0 19414000.0 24543000.0 True False 16677233.547940949 27166111.44267255 18114452.025782377 1.0 1.6289339214792378 1.086178470410572 23.991376655771226 -10.207920870146276 4.347696706258441 0.9998725507318452 1.3575561959219151 0.3665489740462049 0.22157898507665996 155886193.3350348 47.207778636338084 200865.73280641757 0.07585238024162416 6.195539495189797e-11 10.207920870146276 0.3576836451900699 IEDGNDFGVAIQEK(ub)VLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEDGNDFGVAIQEKVLER 18 1 A0A087X1Z3;Q9UL46;H0YM70;H0YKU2 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 1 126397000.0 49711000.0 39716000.0 36970000.0 True False 75415221.36090328 32628369.497475646 29662863.295473367 1.0 0.4326496549195416 0.3933272721367516 26.168352402103693 -13.999999999999998 0.37906630402367963 9.367967629994531 0.3898159522274906 0.9998060100795445 0.0038606377704406693 23.917353750350678 0.20069311150591726 163.26057466133796 0.010687864602945834 1.0000000000000041e-14 13.999999999999998 -8.978151677767041 IEDGNDFGVAIQEK(ub)VLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEDGNDFGVAIQEKVLER 18 1 A0A087X1Z3;Q9UL46;H0YM70;H0YKU2 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 1 21333300.0 5319100.0 6187400.0 9826800.0 True False 7285715.013272644 5914020.209004375 7505912.229298808 1.0 0.8117281829210442 1.0302231442795968 22.796639133306957 -6.678725215161921 1.9066338428123102 0.8807415375301344 1.0293794343121994 0.3182383593584328 0.0798164510883806 0.4413403873546315 3.1008648820179188 0.03360631793744479 0.08877236758265272 2.0954378524569475e-07 6.678725215161921 0.14863789678206496 IEDGNDFGVAIQEK(ub)VLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEDGNDFGVAIQEKVLER 18 1 A0A087X1Z3;Q9UL46;H0YM70;H0YKU2 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 1 57665000.0 17224000.0 25662000.0 14779000.0 True False 14322519.152576506 25523753.712491788 17869220.56962469 1.0 1.782071536479689 1.2476311170727363 23.771781931205503 -10.126563496588567 4.5593709883726055 0.9999511125245073 1.5148513267888344 0.5530490671754116 0.21818438763716383 152274629.03318402 9.735983962208161 85724.58269567166 0.07469031924364339 7.47199380949142e-11 10.126563496588567 0.5149002142643271 IEDGNDFGVAIQEK(ub)VLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEDGNDFGVAIQEKVLER 18 1 A0A087X1Z3;Q9UL46;H0YM70;H0YKU2 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 1 110214000.0 49711000.0 33867000.0 26636000.0 True False 64351869.45030648 31982271.678514335 21788521.308439605 1.0 0.49699056067378966 0.33858412342263094 25.939478724196142 -13.999999999999998 0.16173170923596838 3.486533323758882 0.18580030783816495 0.9995319202773143 0.006100538692376556 12.02170332582989 0.12714484584956462 9.37605665376107 0.13955799239709704 1.0000000000000041e-14 13.999999999999998 -3.300733015920717 IEDLSQQAQLAAAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEDLSQQAQLAAAEK 15 0 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5 F8W0W4 NACA Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form 0 52888700.0 5280700.0 34043000.0 13565000.0 False True 6923048.838371545 28963917.09857468 12161423.92466812 1.0 4.18369388614448 1.756657248647802 22.72297609494925 -6.5773215314534585 2.2769792280239547 3.1714953694104193 1.7623436644859007 0.0 1.3840276942946057 0.7075622902414558 6.895929157356066 0.511183618053373 1.5485662875084953 2.6465400378487655e-07 6.5773215314534585 -1.4091517049245186 IEDLSQQAQLAAAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEDLSQQAQLAAAEK 15 0 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5 F8W0W4 NACA Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form 0 50993700.0 5280700.0 23165000.0 22548000.0 False True 7233117.495551658 22141493.70358894 17222626.790636756 1.0 3.0611273378603183 2.3810793618697073 22.78618615647214 -10.128339208360432 5.3826913129311285 0.999965011447259 2.7211033498657136 0.8951815806995189 0.277628423634035 0.00011657390715368978 1.8876550746786633e-05 0.26881797719485784 0.08960418843034754 7.441505235466063e-11 10.128339208360432 1.7211383384184544 IEDLSQQAQLAAAEK(ub)FK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEDLSQQAQLAAAEKFK 17 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5 F8W0W4 NACA Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form 1 316629200.0 116744200.0 158613000.0 41272000.0 True False 153052776.75244114 134948558.66863155 37001569.348979205 1.0 0.8817125800135421 0.24175692943374869 27.189453978224744 -6.93806397909933 0.6773458429032627 1.0074809236511375 0.07859152352408098 0.9978990018393256 0.015267170686989177 0.08866140488928222 0.05871811507980146 0.014651744673118557 0.05556605103918591 1.1532833466936988e-07 6.93806397909933 -0.9288894001270566 down IEDLSQQAQLAAAEK(ub)FK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEDLSQQAQLAAAEKFK 17 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5 F8W0W4 NACA Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form 1 532080100.0 246182100.0 217262000.0 68636000.0 True False 238367183.9887685 304015849.6063624 50658172.564136386 1.0 1.2754098299902188 0.21252158840171273 27.828610392737037 -6.8379022850135005 1.2920542919284317 1.146576040604244 0.17897856512175733 0.9207973301754001 0.12675464033919395 0.17126058958154167 0.556266926858558 0.07695056120764286 0.17719671796636607 1.4524383752072403e-07 6.8379022850135005 -0.9675974754824866 down IEDLSQQAQLAAAEK(ub)FK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEDLSQQAQLAAAEKFK 17 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5 F8W0W4 NACA Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form 1 582198000.0 354868000.0 161030000.0 66300000.0 True False 538360700.3259046 132292938.36686735 53195775.939677715 1.0 0.24573290414174337 0.09881065967013355 29.00399785791359 -13.999999999999973 0.22999698644017566 5.761398740829126 0.027373760143983534 0.9995097898749793 0.008740655782951757 13.291170357886386 0.1518496273149491 28.899895543748386 0.0762671667959763 1.0000000000000614e-14 13.999999999999973 -5.734024980685143 IEDLSQQAQLAAAEK(ub)FK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEDLSQQAQLAAAEKFK 17 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5 F8W0W4 NACA Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form 1 302340200.0 116744200.0 143832000.0 41764000.0 True False 159907685.63337865 137477026.65118098 31900203.356579486 1.0 0.859727449038162 0.19949137047557103 27.252664039747636 -6.941162957880754 0.6486656926748947 1.0072879347912718 0.015192654340555228 0.9983121458565782 0.014339404083077987 0.08724037091721623 0.0522258701973654 0.014084405591287168 0.05654049009490732 1.1450831976844824e-07 6.941162957880754 -0.9920952804507165 down IEDLSQQAQLAAAEK(ub)FK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEDLSQQAQLAAAEKFK 17 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5 F8W0W4 NACA Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form 1 497027600.0 246182100.0 222364500.0 28481000.0 True False 204711323.86620414 221166578.30260265 34436245.41873472 1.0 1.0803827268839967 0.16821856636148605 27.609015668171313 -6.885419347148002 1.0490790746548164 1.0545274067395907 0.09645282162910666 0.9778015966535496 0.06143801167132316 0.12293932575191716 0.2441779294187396 0.04486860152494209 0.1101660858170876 1.3019090707351532e-07 6.885419347148002 -0.958074585110484 down IEDLSQQAQLAAAEK(ub)FK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEDLSQQAQLAAAEKFK 17 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5 F8W0W4 NACA Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form 1 694899900.0 354868000.0 273096900.0 66935000.0 True False 459383621.49406326 257898817.44353145 54753516.81109796 1.0 0.5614018553921483 0.11918909218622535 28.77512418000604 -7.772982606624018 0.43825615632531423 1.0359290587903962 6.3589324952188755e-22 0.9971661016753616 0.019142576463847392 0.1138743334463512 0.08070487465052854 0.031619239116862055 0.07750595109332134 1.686620572731708e-08 7.772982606624018 -1.0359290587903962 down IEDVGSDEEDDSGK(ub)DKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEDVGSDEEDDSGKDKK 17 2 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 9682120.0 3331200.0 5425100.0 925820.0 True False 4367235.459386684 4615696.226874174 830025.0274925361 1.0 1.0568920017704706 0.19005731090329198 22.058288885405013 -6.891216124078895 1.0151313207149726 1.0452270871270088 0.11369217878364635 0.9816663489532274 0.05360586165539441 0.11816313178575168 0.21611419282622868 0.04016953925089151 0.1005947326359409 1.2846472037672232e-07 6.891216124078895 -0.9315349083433625 down IEDVGSDEEDDSGK(ub)DKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEDVGSDEEDDSGKDKK 17 2 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 8762540.0 2118300.0 6151900.0 492340.0 True False 1761460.3066014142 6118758.493643454 595286.0176770431 1.0 3.4736851410799434 0.3379502878640485 20.748340534299253 -6.696387448387166 1.8434533511510758 2.541479044612712 0.3478085505124891 0.40049507862154465 1.044883947460758 0.40313642788363463 2.660773804730833 0.45259571294650175 1.1693049426368045 2.011928541371033e-07 6.696387448387166 -2.193670494100223 IEDVGSDEEDDSGKDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEDVGSDEEDDSGKDK 16 1 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 5530630.0 1449900.0 648030.0 3432700.0 False True 1403873.7181351348 906791.7584318059 2533572.8912073993 1.0 0.6459211727649989 1.8047014189943837 20.42098173686551 -6.8246948388775195 1.3513578158359218 0.8100012810016636 1.8326549071147527 0.8948542209873347 0.15721734662863665 0.1874538838841127 0.6713105588381183 0.09138936008053666 0.21042976376389533 1.4972873696749585e-07 6.8246948388775195 1.022653626113089 IEDVGSDEEDDSGKDK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEDVGSDEEDDSGKDK 16 1 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 1 6066630.0 2702700.0 2807600.0 556330.0 True False 3543265.87298403 2388717.0239390866 498766.3082941851 1.0 0.6741568681458787 0.1407645731857371 21.75664829310506 -7.375270523055239 0.5101943165843755 1.0108006857744172 1.262177448353619e-29 0.9978513996472528 0.016417124351181537 0.10765182530004157 0.05822447156521259 0.017818713114124075 0.06179079027963786 4.214339094774808e-08 7.375270523055239 -1.0108006857744172 down IEDVTPIPSDSTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEDVTPIPSDSTR 13 0 P62263;A0A2R8Y811 P62263 RPS14 40S ribosomal protein S14 0 25076700.0 8409700.0 3085000.0 13582000.0 False True 8142738.676737048 4316856.588062467 10024466.7487339 1.0 0.530147995587194 1.2310927743969917 22.957082672271827 -6.726057952243349 1.737332862494813 0.7160149968704502 1.2304051558039508 0.5410078913143781 0.19758348898607858 0.3436835038636112 2.0303193224741922 0.09018867667367055 0.22482594755066979 1.8790660575515556e-07 6.726057952243349 0.5143901589335006 IEEACEIYAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEEACEIYAR 10 0 P54920;M0R0Y2;M0R2M1 P54920 NAPA Alpha-soluble NSF attachment protein 0 2208320.0 913320.0 0.0 1295000.0 False True 1250999.085544953 0.0 989147.6713621869 1.0 0.0 0.7906861665940389 20.254649304247376 -10.865883089729733 8.36864934338985 1.0456175150315212 0.39534308329727796 0.43811943325792846 0.32279627580544157 0.1667023872857535 0.002671587553880466 0.18964375732616318 0.10418205003435425 1.361811227052321e-11 10.865883089729733 -0.6502744317342433 IEECVVCSDK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEECVVCSDKK 11 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 29188500.0 6176400.0 7276400.0 15735700.0 True False 8097320.21234268 6190789.483185048 14107520.711492835 1.0 0.764547939421795 1.7422456246683753 22.949013100033287 -6.843112220240922 1.267874308407107 0.8747516113239631 1.77643324015723 0.9296724213985119 0.1104887589124932 0.16519483871936266 0.5144875410161628 0.06829559815396345 0.15749506114460055 1.4351185556062464e-07 6.843112220240922 0.901681628833267 IEECVVCSDK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEECVVCSDKK 11 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 11335630.0 5917030.0 3261500.0 2157100.0 True False 5729197.121468474 4563833.958497814 1592090.7983871214 1.0 0.7965922382730023 0.27789073488521304 22.449901545996816 -6.955035290952806 0.5005221267990998 1.0103411268545055 0.041749917357330794 0.9995394800064723 0.0065242405656630005 0.08152462317555216 0.028065593628691505 0.007643758860443943 0.04278895778848094 1.1090846869109915e-07 6.955035290952806 -0.9685912094971747 down IEECVVCSDK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEECVVCSDKK 11 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 65977000.0 9550100.0 39427200.0 16999700.0 True False 14488199.905830938 32391108.11388039 13639701.843766803 1.0 2.235688927845634 0.941435232287025 23.78837502182162 -6.656682045310947 1.984773122613444 1.7975691581563915 0.9468689927950602 0.2215460655023126 0.5265500759849602 0.4923639497096529 3.725005220242752 0.21460534793284308 0.5834763579054659 2.2045398550933025e-07 6.656682045310947 -0.8507001653613313 IEECVVCSDK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEECVVCSDKK 11 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 28661190.0 6176400.0 6562090.0 15922700.0 True False 8459981.990934012 6272155.165870234 12162086.198300172 1.0 0.7413910777341697 1.437601901674667 23.01222316155618 -6.806102263821986 1.4306626291161015 0.8583987072663571 1.4487487794693097 0.8494666484137916 0.11148435419556423 0.2121554004713865 0.8565120150646229 0.06128346836265087 0.14204038408530673 1.5627796097969658e-07 6.806102263821986 0.5903500722029525 IEECVVCSDK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEECVVCSDKK 11 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 22748030.0 5917030.0 1692400.0 15138600.0 True False 4920272.61387423 1683282.7052849003 18304011.267022118 1.0 0.34211167497881406 3.7201213638870945 22.230306821431093 -6.856180586835455 1.204878853814031 0.6460849545178047 3.872166879561073 0.9488287059508497 0.33077020307950944 0.15078645398280335 0.4181481885037207 0.21442430343651325 0.4985719662879653 1.3925776257065832e-07 6.856180586835455 3.2260819250432684 up IEECVVCSDK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEECVVCSDKK 11 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 21452000.0 9550100.0 4292300.0 7609600.0 True False 12362792.710614782 4053429.7317650556 6224730.88108958 1.0 0.3278733071601817 0.5035052375944945 23.559501343914068 -10.71655193032876 10.336716679109093 1.0006866279380513 0.41568927237917874 0.936539074955333 0.07170143535067632 0.0011356071561986092 3.113996018890897e-05 0.06948763061357578 0.02314153875102808 1.9206492883011163e-11 10.71655193032876 -0.5849973555588726 IEEELGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEEELGSK 8 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 68231500.0 3031500.0 35778000.0 29422000.0 False True 3974325.85708776 30440061.8615517 26377693.675752714 1.0 7.65917616122626 6.637023390699352 21.92227873409385 -9.063038694181351 10.298861193210573 0.9999994826089748 7.14809963624578 0.9796904663258761 0.41729212118892034 0.0 0.0 0.40404135895428495 0.1346804529847616 8.648908564690025e-10 9.063038694181351 6.148100153636805 IEEELGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEEELGSK 8 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 71787800.0 22264000.0 7970800.0 41553000.0 False True 21557241.506697442 11153582.00717288 30669022.73672063 1.0 0.5173937492748163 1.4226784408938558 24.361669244935598 -6.76187954069382 1.6053017279461093 0.7203279415394405 1.4263065158704131 0.698608777295132 0.20304477116717998 0.27978135280018024 1.4214033491764126 0.09977465697699578 0.2393403026991556 1.730296221123816e-07 6.76187954069382 0.7059785743309727 IEEELGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEEELGSK 8 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 98850500.0 3031500.0 55448000.0 40371000.0 False True 4152327.473207122 52998124.017984085 30836201.266843952 1.0 12.763474066039898 7.426245031446683 21.985488795616742 -9.173532681234168 10.40112134555577 1.0000494773350637 10.094859548743921 0.794731849956099 2.178914629376334 0.0 0.0 2.109724766523563 0.7032416726699705 6.706058208285193e-10 9.173532681234168 9.094810071408858 IEEELGSK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEEELGSKAK 10 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 30289200.0 12423700.0 11386400.0 6479100.0 True False 16287591.011281947 9687593.503839575 5808704.8839157615 1.0 0.5947836912855472 0.35663376369729805 23.957269904472838 -9.041666789020624 0.16154986262838003 1.4821383087074647 5.7211086907753764e-11 0.999793375808839 0.0038176800002552983 0.5035622968463108 0.053241496287014835 0.2826355319562784 0.16346157561057625 9.085173196947041e-10 9.041666789020624 -1.4821383086502535 IEEELGSK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEEELGSKAK 10 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 26548800.0 10830000.0 6134800.0 9584000.0 True False 10486207.578042274 8584457.632559374 7073662.886162998 1.0 0.8186427331969764 0.6745682682245374 23.32198967409968 -6.973722526611915 0.14370543472953984 1.18302818181431 0.30641349180486244 0.9999987926659888 0.00014618657607446976 0.0751122550690675 0.004366604805649231 0.007836794255688622 0.01845661567479035 1.0623740976916164e-07 6.973722526611915 -0.8766146900094476 IEEELGSK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEEELGSKAK 10 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 189978500.0 24163700.0 27476800.0 138338000.0 True False 36658099.50309711 22573350.362781737 110995433.66430074 1.0 0.6157807051856192 3.027855649061216 25.12762865716709 -6.866131816465001 1.1544382120317387 0.787057298684965 3.159066205796347 0.9606635789617226 0.2098755291835674 0.14061354893918332 0.35269307693397056 0.14140294036135295 0.33268842821135364 1.3610315213489728e-07 6.866131816465001 2.3720089071113817 up IEEELGSK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEEELGSKAK 10 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 25467000.0 12423700.0 10720800.0 2322500.0 True False 17017077.627868492 10247119.607055308 1773973.333388945 1.0 0.6021668250648294 0.10424664987622483 24.02047996599573 -7.616562293700306 0.4955740029941255 1.0174215741085701 1.6753013002216143e-22 0.9963485581650576 0.0221435268444102 0.11783472236588091 0.08201507716734985 0.026230460905952747 0.07329095675067193 2.4178964983346574e-08 7.616562293700306 -1.0174215741085701 down IEEELGSK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEEELGSKAK 10 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 46143000.0 10830000.0 28443000.0 6870000.0 True False 9005624.85034854 28289771.913506523 8306485.236708954 1.0 3.1413447021848393 0.9223663404530417 23.102394949533956 -6.654290148169696 1.9931852037325792 2.384807320798349 0.9317052920283838 0.21156955026107338 0.912999459544892 0.49816043326615334 3.798195801089085 0.37086563069267414 1.011564404063803 2.2167149579986215e-07 6.654290148169696 -1.4531020287699654 IEEELGSK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEEELGSKAK 10 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 177956700.0 24163700.0 32792000.0 121001000.0 True False 31280385.987736564 30967096.37351532 98980059.57510512 1.0 0.9899844709606822 3.164285108691118 24.89875497925954 -6.905862716744544 0.9234516972287032 0.923557981363703 3.4217608131661987 0.9892643161582247 0.10595714802187646 0.10721780602704363 0.15407916168231345 0.08501171577510719 0.22845865869667892 1.2420448638470167e-07 6.905862716744544 2.498202831802496 up IEEFLEAVLCPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEEFLEAVLCPPR 13 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 5836840.0 3396900.0 909440.0 1530500.0 False True 3289067.2688690503 1272584.1346669467 1129616.1359841882 1.0 0.3869133801889453 0.3434457381507457 21.64924708417774 -13.999999999999998 0.37572870200692676 9.853686155753703 0.33933792241471566 0.9998005434917685 0.004233802286811493 23.504257478439243 0.19948901996277932 168.02357022016562 0.011934917208547526 1.0000000000000041e-14 13.999999999999998 -9.514348233338987 IEEGTYGVVYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEEGTYGVVYR 11 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 4991000.0 1003500.0 1349500.0 2638000.0 False True 1315598.2179078234 1148159.8603097994 2365045.065482826 1.0 0.8727283487322606 1.7976955527075147 20.327287528355576 -6.872123771195884 1.1227524670640074 0.9270011806401643 1.8541096862635462 0.9667595600085607 0.07463188347460807 0.1348372530875008 0.31637654567684026 0.051516813416310016 0.12244285631075635 1.3423823360946007e-07 6.872123771195884 0.9271085056233819 IEEGTYGVVYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEEGTYGVVYR 11 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 4863900.0 1003500.0 1553800.0 2306600.0 False True 1374521.06856782 1485147.978270515 1761828.5859181639 1.0 1.0804839680034608 1.2817763410159282 20.390497589878468 -6.955452888085709 0.4953788443725886 0.9958021478076168 1.3750721380636106 0.9995626234877639 0.0024783855018321514 0.0813672469348497 0.027451534048379845 0.0029324034566313496 0.016602802598146296 1.1080187558339425e-07 6.955452888085709 0.37926999025599384 IEEHSEDMETHVK(ub)TK ddPTM_RPMI8226_Bortezomib_1h_R1 2 IEEHSEDMETHVKTK 15 1 Q96AP4;X6R6X3 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 6587870.0 2275450.0 2359050.0 1953370.0 True False 2983136.9854891477 2007088.9355048777 1751254.0104481385 1.0 0.6728115219877419 0.5870511541933042 21.508398796996715 -13.999999999999998 0.18796968127494146 2.7418017213276267 0.5242529855113306 0.9994906529270406 0.004015662987362249 12.318375287340018 0.13748549010601024 7.853449724784262 0.05994493090895057 1.0000000000000041e-14 13.999999999999998 -2.217548735816296 IEEHSEDMETHVK(ub)TK ddPTM_RPMI8226_Bortezomib_2h_R1 2 IEEHSEDMETHVKTK 15 1 Q96AP4;X6R6X3 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 12160700.0 2782400.0 3164700.0 6213600.0 True False 2694074.2350087585 4428381.213692479 4586071.755995657 1.0 1.643748771339288 1.702281138507955 21.361358174023216 -11.371927334574664 0.40718421371470864 7.571945152861411e-19 1.7058987657603162 0.9996500726652277 0.005951624988278498 3.6373411440056382 0.20294209152852216 3.2573114260344975 0.014665433564727675 4.246906165246134e-12 11.371927334574664 1.7058987657603162 IEEHSEDMETHVK(ub)TK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEEHSEDMETHVKTK 15 1 Q96AP4;X6R6X3 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 14989700.0 2043400.0 7549400.0 5396900.0 True False 3099987.1925503374 6202150.58626857 4330200.349454695 1.0 2.0007020032770217 1.396844593377907 21.563830824410047 -10.704669585862378 6.620157374547963 0.9922518098170611 1.6987732983259298 0.6409888505552985 0.2465237552752508 0.02811220850050768 0.0012541059062578372 0.23801700604697953 0.07956519988546314 1.9739239394745666e-11 10.704669585862378 0.7065214885088688 IEEHSEDMETHVK(ub)TK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IEEHSEDMETHVKTK 15 1 Q96AP4;X6R6X3 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 11967180.0 2782400.0 5760400.0 3424380.0 True False 2313688.881219742 5729367.581850119 4140402.0254558036 1.0 2.476291271637906 1.7895241054506197 21.141763449457493 -10.08289441789481 4.659302536818012 0.9999395881747252 2.132907688570929 0.7839401108301157 0.28037152163393697 97416138.4574505 8.05458151782815 63137.77166695795 0.09597862928691159 8.262387935474636e-11 10.08289441789481 1.1329681003962038 IEEHSEDMETHVK(ub)TK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEEHSEDMETHVKTK 15 1 Q96AP4;X6R6X3 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 15481400.0 2043400.0 7066600.0 6371400.0 True False 2645221.5814358257 6673337.497959363 5211870.576084697 1.0 2.5227896009895234 1.9702964064188886 21.334957146502497 -10.5756318868818 7.1246396179366895 0.9988190373237131 2.2465430037041734 0.8715863943202474 0.22555440217638012 0.004233515812086584 0.0002521620134496476 0.21851671331034572 0.07279737027440754 2.6568565907816464e-11 10.5756318868818 1.2477239663804602 IEEIKDFLLTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEEIKDFLLTAR 12 1 P63173;J3KT73;J3QL01;J3KSP2 P63173 RPL38 60S ribosomal protein L38 0 7155500.0 2009500.0 1812400.0 3333600.0 False True 1945709.522444688 2536100.7715411396 2460430.1541436734 1.0 1.3034323686480467 1.2645413540723511 20.891864913662737 -10.110859204157514 4.687742167460153 0.9999807142983177 1.283986861364506 0.9861293360330635 0.015877190229692955 3.200382405372693e-06 6.070594444076882e-07 0.015374066842394904 0.005124341109925102 7.747129146897719e-11 10.110859204157514 0.2840061470661883 IEEK(ub)LTPLPEDNSMNVDQDGDPSDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEEKLTPLPEDNSMNVDQDGDPSDR 25 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 7250200.0 1778800.0 2872100.0 2599300.0 True False 2436470.4302625186 2745201.1252353876 1985398.8742638864 1.0 1.126712268344502 0.814866804704036 21.216361282979996 -6.796380588331469 1.4705110525946048 1.0702368881972415 0.8109305251424999 0.8214063106928933 0.05411559640816073 0.22596547115717674 0.9649833216783029 0.028955342748447074 0.06749731597165014 1.5981568907249516e-07 6.796380588331469 -0.25930636305474164 IEELDQENEAALENGIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEELDQENEAALENGIK 17 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;Q68E03 P43243 MATR3;DKFZp686L22104 Matrin-3 0 7544200.0 0.0 3802800.0 3741400.0 False True 0.0 3235437.0631982996 3354275.8180430005 0.0 IEELDQENEAALENGIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEELDQENEAALENGIK 17 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;Q68E03 P43243 MATR3;DKFZp686L22104 Matrin-3 0 6565400.0 0.0 2955300.0 3610100.0 False True 0.0 2824725.07412978 2757468.73234335 0.0 IEELGSELK(ub)EHYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEELGSELKEHYK 13 1 Q14181;A0A3B3ITS5;Q14181-2 Q14181 POLA2 DNA polymerase alpha subunit B 1 9490500.0 3160700.0 2346600.0 3983200.0 True False 4143708.3082623384 1996496.4269751597 3571056.673552385 1.0 0.4818139401835428 0.8618021366107947 21.98249101901015 -10.282499096730794 5.878679660342375 1.000019868723836 0.6718080383971707 0.49864976893759516 0.15512953158787732 4.039927564241122e-05 4.930707337338471e-06 0.1502126062942741 0.050067841028733136 5.217961894978749e-11 10.282499096730794 -0.32821183032666523 IEELGSELK(ub)EHYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEELGSELKEHYK 13 1 Q14181;A0A3B3ITS5;Q14181-2 Q14181 POLA2 DNA polymerase alpha subunit B 1 13052600.0 2158100.0 3279800.0 7614700.0 True False 2089592.2967842172 4589441.243931047 5620181.633896626 1.0 2.1963333474161337 2.689606791978424 20.99479005288141 -9.724886395266779 0.23687994929877346 6.443900580843106e-17 3.0166346392965213 0.9991820147893602 0.020289304238662802 1.1494644855163854 0.10068033966689176 1.0401864991370333 0.23403918432627363 1.8841418874692423e-10 9.724886395266779 3.0166346392965213 IEELGSELK(ub)EHYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEELGSELKEHYK 13 1 Q14181;A0A3B3ITS5;Q14181-2 Q14181 POLA2 DNA polymerase alpha subunit B 1 57047200.0 4841200.0 11404000.0 40802000.0 True False 7344454.339128259 9368867.100141311 32737466.81584812 1.0 1.2756382799233712 4.4574403085925995 22.808223878148407 -6.923961011089245 0.7947946861003315 0.9393015509278388 5.020391298259616 0.9952123498157901 0.10855839638900866 0.09589706087614891 0.09394492999558017 0.09555270497321752 0.2980273330076366 1.1913489569183988e-07 6.923961011089245 4.081089747331777 up IEELGSELK(ub)EHYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEELGSELKEHYK 13 1 Q14181;A0A3B3ITS5;Q14181-2 Q14181 POLA2 DNA polymerase alpha subunit B 1 11256100.0 2158100.0 4481000.0 4617000.0 True False 1794555.7700403712 4456859.963591137 5582393.3534039585 1.0 2.483544974192066 3.110738293342856 20.775195328315686 -9.46678462300535 0.2551125477037669 1.1528192250036176e-13 3.48225445648211 0.9990529123058763 0.027236593129897485 0.8691043445350902 0.1011487447279215 0.9781775997093856 0.26715283516698307 3.413621592902383e-10 9.46678462300535 3.4822544564819946 IEELGSELK(ub)EHYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEELGSELKEHYK 13 1 Q14181;A0A3B3ITS5;Q14181-2 Q14181 POLA2 DNA polymerase alpha subunit B 1 60355600.0 4841200.0 7749400.0 47765000.0 True False 6267028.834318837 7318139.077729927 39072260.11028744 1.0 1.1677206649593044 6.23457481100519 22.579350200240857 -6.91393803982756 0.8684744393279893 0.8619761064820431 6.94771657438416 0.9923250214075627 0.21280039096595554 0.10187146534030568 0.12506330770099433 0.17768845972074226 0.5049840754808897 1.2191635228335256e-07 6.91393803982756 6.0857404679021165 up IEELNK(ub)TANGNVEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEELNKTANGNVEAK 15 1 O94776;E7ESY4;Q13330-2;Q13330-3;Q13330;H7C3F3 O94776 MTA2;MTA1 Metastasis-associated protein MTA2;Metastasis-associated protein MTA1 1 5031800.0 1470200.0 1437200.0 2124400.0 True False 1423529.3057467921 2011081.4548989884 1567955.9093660961 1.0 1.412743276011422 1.1014567125778538 20.44104076301578 -9.915557794964384 5.766914746613854 0.9999998567098798 1.257099994294904 0.47631384895282725 0.12708220736706727 2.3410330086337297e-07 4.4193892031712514e-08 0.12304688602314574 0.04101560611487698 1.2146249700681064e-10 9.915557794964384 0.25710013758502415 IEELNK(ub)TANGNVEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEELNKTANGNVEAK 15 1 O94776;E7ESY4;Q13330-2;Q13330-3;Q13330;H7C3F3 O94776 MTA2;MTA1 Metastasis-associated protein MTA2;Metastasis-associated protein MTA1 1 15124700.0 5013200.0 2593400.0 7518100.0 True False 7605390.914012593 2130587.507673316 6032144.239699709 1.0 0.28014174836796407 0.7931405903917118 22.858590973120524 -9.944466761509494 6.424376966346817 1.0000000766962294 0.5366411693810257 0.5210222066304631 0.20943090026619726 2.3001758222170858e-07 3.809786650323702e-08 0.20278063046609046 0.06759353240934174 1.1364052684944653e-10 9.944466761509494 -0.4633589073152037 IEELQEQLEQK(ub)HR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEELQEQLEQKHR 13 1 Q9UJC3;Q9UJC3-2 Q9UJC3 HOOK1 Protein Hook homolog 1 1 10930800.0 2260100.0 2939800.0 5730900.0 True False 2925744.003231433 2776197.5457081115 4687935.003999719 1.0 0.9488860073341515 1.6023052593876896 21.48037211138238 -6.887996655111187 1.0341835235896146 0.9631862360705924 1.656343471044126 0.9795839065123567 0.04239563306072429 0.12078270274355511 0.2314743499463125 0.03131519890506398 0.07752532925433993 1.2942058092438287e-07 6.887996655111187 0.6931572349735337 IEELQLIVNDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEELQLIVNDK 11 0 P62195;J3QQM1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 0 7711200.0 1821000.0 2730000.0 3160200.0 False True 2387348.6345890868 2322694.641456652 2833212.818778934 1.0 0.9729180764821292 1.1867612370183167 21.1869778339698 -6.875126262593824 1.106669557301988 0.984090174377906 1.200565341922057 0.9695346458611417 0.016593557024423257 0.13203236533829737 0.29914904988638985 0.011596905191629547 0.027727184429465666 1.3331337933407455e-07 6.875126262593824 0.21647516754415097 IEELQLIVNDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEELQLIVNDK 11 0 P62195;J3QQM1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 0 7165200.0 1821000.0 2553000.0 2791200.0 False True 2494272.910674641 2440200.0183579763 2131976.046568445 1.0 0.9783211804589422 0.8547485070476095 21.25018789549269 -6.936932832204059 0.6875375981243649 1.0014879409214152 0.824234429252652 0.9977334479041841 0.003045859466005016 0.0891948994054226 0.06120054244600763 0.0029000097208557256 0.010787260325853113 1.156291059836907e-07 6.936932832204059 -0.17725351166876324 IEELQLIVNDK(ub)SQNLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEELQLIVNDKSQNLR 16 1 P62195;J3QQM1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 25101800.0 5519100.0 8662700.0 10920000.0 True False 7235593.547040431 7370258.926940127 9790103.152036553 1.0 1.018611518049515 1.3530476924095594 22.786679937463163 -6.918371725646728 0.8367197985410163 0.9921789815830663 1.4050082372938406 0.9937164290392161 0.012858976058252154 0.09913927327708082 0.11065037124768079 0.010984842857544893 0.03240938533732219 1.2067804733977118e-07 6.918371725646728 0.41282925571077433 IEELQLIVNDK(ub)SQNLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEELQLIVNDKSQNLR 16 1 P62195;J3QQM1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 77156000.0 29049000.0 27600000.0 20507000.0 True False 44069456.76636718 22674564.360215764 16453782.461462611 1.0 0.5145188078996354 0.3733602288018165 25.39327577718045 -13.999999999999872 0.17319421524733755 3.4694411094832076 0.2529839024389787 0.9995079479747242 0.005953473630215901 12.124247488803498 0.13184439304009346 10.06257150971481 0.11182246261233263 1.0000000000002946e-14 13.999999999999872 -3.216457207044229 IEELQLIVNDK(ub)SQNLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEELQLIVNDKSQNLR 16 1 P62195;J3QQM1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 33981100.0 5519100.0 10775000.0 17687000.0 True False 7559660.418069416 10298924.871839892 13509694.875199238 1.0 1.362352844212813 1.7870769489735017 22.849889998986054 -6.969031796956682 0.28034935017506557 0.9068239427680707 2.255554263189347 0.9999738141101902 0.0016459878498302773 0.07661814968866029 0.010149864328816241 0.007829405722170665 0.03896717671379439 1.0739107828717486e-07 6.969031796956682 1.3487303204212762 IEELQLIVNDK(ub)SQNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEELQLIVNDKSQNLR 16 1 P62195;J3QQM1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 71174000.0 29049000.0 25568000.0 16557000.0 True False 37604503.14139633 24145118.32392167 13543795.889166312 1.0 0.6420805038464101 0.3601642026286165 25.1644020992729 -7.675844088540086 0.21367422241726658 1.1944497842708603 1.540560861061506e-14 0.9998904856264417 0.0027399739087811846 0.13122369814790338 0.02631714582749481 0.04390076688564962 0.07990984514316965 2.109385282078023e-08 7.675844088540086 -1.194449784270845 down IEENSLK(ub)EEESIEGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEENSLKEEESIEGEK 16 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y7I0;A0A2R8Y7M9;A0A2R8Y5M9;A0A2R8YE38 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 5323900.0 1404100.0 2550100.0 1369700.0 True False 1840788.6973237423 2169635.0202119458 1227976.5830901528 1.0 1.1786442536105863 0.6670926352793586 20.811892599695334 -6.8123597608554025 1.4045510243509034 1.0970916704144285 0.6576484891152353 0.8659085982444996 0.07762450064271179 0.20360041140358887 0.7911624418657291 0.04345031107184768 0.10040825970381709 1.5404238679767474e-07 6.8123597608554025 -0.43944318129919313 IEENSLK(ub)EEESIEGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEENSLKEEESIEGEK 16 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y7I0;A0A2R8Y7M9;A0A2R8Y5M9;A0A2R8YE38 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 4374700.0 1422200.0 1496000.0 1456500.0 True False 1377053.039472923 2093360.6015369394 1074998.9559366028 1.0 1.520174271819035 0.7806518159591489 20.39315269765028 -6.7176764077175175 1.7676731287362437 1.3172510904859445 0.7819525388720787 0.5015231403932221 0.21895605040099003 0.35985600313707233 2.1962225640209865 0.09840063970285019 0.24770036230626338 1.915682766251152e-07 6.7176764077175175 -0.5352985516138657 IEENSLK(ub)EEESIEGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEENSLKEEESIEGEK 16 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y7I0;A0A2R8Y7M9;A0A2R8Y5M9;A0A2R8YE38 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 5268800.0 1404100.0 1869900.0 1994800.0 True False 1923233.7143757613 1787281.6350676017 1523669.3241955924 1.0 0.9293106821641348 0.7922434558038837 20.875102661218225 -6.960646060018295 0.42623143454706314 1.0056672165161669 0.710663180547371 0.9997934092513587 0.0012396401497156392 0.07947113562435701 0.020284567175140572 0.0017812703259176953 0.011391134325025332 1.0948482788630401e-07 6.960646060018295 -0.2950040359687959 IEENSLK(ub)EEESIEGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEENSLKEEESIEGEK 16 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y7I0;A0A2R8Y7M9;A0A2R8Y5M9;A0A2R8YE38 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 4485000.0 1422200.0 3062800.0 0.0 True False 1182622.314142726 3046300.0884817964 0.0 1.0 2.5758858530333386 0.0 20.173557973084556 -6.741918211125716 1.6848556093352611 1.936353331054742 2.550867378490911e-09 0.6100474336548085 0.6621325526746715 0.31507049316043123 1.757824183929536 0.31110052531720284 0.7602853918770099 1.811681246892034e-07 6.741918211125716 -1.9363533285038748 IEETALK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEETALKK 8 1 A0A0B4J2G4;Q15345-3;Q15345;A0A087X0S7 A0A0B4J2G4 LRRC41 Leucine-rich repeat-containing protein 41 1 2995070.0 829220.0 720150.0 1445700.0 True False 1087115.450177903 612706.4271227132 1296112.8321336312 1.0 0.5636075055528331 1.1922494818020721 20.052073730070838 -6.720021445523783 1.7593716262484207 0.7345043298872916 1.1912602526675493 0.5125219053838468 0.18363566059917835 0.3552945708933698 2.149360405202276 0.08287759396835698 0.20803802811742964 1.9053666283628974e-07 6.720021445523783 0.4567559227802577 IEETALK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEETALKK 8 1 A0A0B4J2G4;Q15345-3;Q15345;A0A087X0S7 A0A0B4J2G4 LRRC41 Leucine-rich repeat-containing protein 41 1 2850810.0 519610.0 781100.0 1550100.0 True False 503115.2649701335 1092997.3033826894 1144082.307996791 1.0 2.17245903569945 2.2739964132567265 18.940529437390804 -10.771439485594454 0.4591164463370314 1.534089164040845e-20 2.2742428989564774 0.999613089322929 0.011371706067864652 2.3663517355603814 0.22083699047306546 2.6350256364048663 0.022402868762548045 1.6926240775135482e-11 10.771439485594454 2.2742428989564774 IEETALK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEETALKK 8 1 A0A0B4J2G4;Q15345-3;Q15345;A0A087X0S7 A0A0B4J2G4 LRRC41 Leucine-rich repeat-containing protein 41 1 5694200.0 1160000.0 1414800.0 3119400.0 True False 1759804.8073594957 1162317.8861171461 2502849.2227184083 1.0 0.6604811404403136 1.42223115441639 20.74698398735082 -6.785518795755611 1.5139864746727743 0.8091329488533349 1.4293847949913379 0.786546568338207 0.14395943546318843 0.2420953819583856 1.0962529031460775 0.0748616841183434 0.1758738168573254 1.6386311417168085e-07 6.785518795755611 0.620251846138003 IEETALK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEETALKK 8 1 A0A0B4J2G4;Q15345-3;Q15345;A0A087X0S7 A0A0B4J2G4 LRRC41 Leucine-rich repeat-containing protein 41 1 4236780.0 829220.0 793160.0 2614400.0 True False 1135805.0428279103 758115.5685706278 1996932.5652581505 1.0 0.6674698033414987 1.7581649050317807 20.11528379159373 -6.824890382839811 1.350489592826127 0.8215922402810258 1.7845845189195568 0.8952706333938721 0.1477115083254297 0.18721121611160246 0.669518076710842 0.08591687410074482 0.19782371052749279 1.496613357886322e-07 6.824890382839811 0.962992278638531 IEETALK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEETALKK 8 1 A0A0B4J2G4;Q15345-3;Q15345;A0A087X0S7 A0A0B4J2G4 LRRC41 Leucine-rich repeat-containing protein 41 1 3096710.0 519610.0 1405000.0 1172100.0 True False 432078.7376260023 1397430.9861293351 1417180.6908219159 1.0 3.2342044734886266 3.279913051515615 18.72093471282508 -10.516969992631308 0.7374649637533793 7.169273630670597e-19 3.2712446226202156 0.999951089980227 0.007442214438883451 1.9557897779080677 0.38018662897214667 3.74559309684097 0.006895063723159007 3.041095141425825e-11 10.516969992631308 3.2712446226202156 IEETALK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEETALKK 8 1 A0A0B4J2G4;Q15345-3;Q15345;A0A087X0S7 A0A0B4J2G4 LRRC41 Leucine-rich repeat-containing protein 41 1 5503540.0 1160000.0 821840.0 3521700.0 True False 1501642.867018479 776103.8815445779 2880786.7356934873 1.0 0.5168365252422081 1.9184233474989343 20.51811030944327 -6.813642880091016 1.3993016614796536 0.7377938989369259 1.9450096190576844 0.8690963175352386 0.21032505935386828 0.20187388852814586 0.7783580144994843 0.1181678200954637 0.2729059870502612 1.5358794157546877e-07 6.813642880091016 1.2072157201207585 IEEVK(ub)STTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEEVKSTTK 9 1 Q9Y265;Q9Y265-2 Q9Y265 RUVBL1 RuvB-like 1 1 2623970.0 1097900.0 1300700.0 225370.0 True False 1063047.7654600765 1820076.2930608925 166338.836044924 1.0 1.712130303263637 0.15647352964702788 20.019774991634566 -6.78223077028855 1.5271018203844968 1.4020538032425873 0.14325939404212362 0.7752368905435818 0.30145080200230107 0.24711959386218582 1.1384018134376512 0.15545252462153883 0.3661366139266932 1.651084231394556e-07 6.78223077028855 -1.2587944092004637 IEEVPELPLVVEDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEEVPELPLVVEDK 14 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 16630000.0 6565700.0 2953000.0 7111300.0 False True 6357275.447382483 4132148.2996915653 5248637.1955729155 1.0 0.6499872994165949 0.8256111032178048 22.599977168053297 -10.139482209578041 5.131020784571523 1.0000100762580282 0.7377992013168764 0.7482338425557977 0.07169811766773165 8.264694949353808e-06 1.3861677631061157e-06 0.0694240698262905 0.023140467973300168 7.253001886509182e-11 10.139482209578041 -0.2622108749411518 IEEVPELPLVVEDK(ub)VEGYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEEVPELPLVVEDKVEGYK 19 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 19143300.0 3114200.0 3294100.0 12735000.0 True False 3015341.425626895 4609451.308504565 9399321.458189234 1.0 1.5286664618903816 3.117166559748735 21.52388993634864 -6.951415733266541 0.5430847512096495 0.9770760087381932 3.7425020430249 0.9993077155292257 0.02367239586077569 0.08292230811526244 0.033648642782363146 0.02592802665862159 0.13161669526694242 1.1183668017249478e-07 6.951415733266541 2.765426034286707 IEEVPELPLVVEDK(ub)VEGYKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEEVPELPLVVEDKVEGYKK 20 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 13064500.0 1096300.0 4337100.0 7631100.0 True False 1437259.916584302 3690021.5858833836 6841506.974680045 1.0 2.5674003312169504 4.760104206439656 20.454889554194665 -6.966390417894972 0.3333284281449902 0.7430170084597152 6.656627412194381 0.9999390037977992 0.01204392957612885 0.07749224967334897 0.01321332639441015 0.031626627803956815 0.19074809296010922 1.080462211007464e-07 6.966390417894972 5.9136104037346655 IEEVPELPLVVEDK(ub)VEGYKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEEVPELPLVVEDKVEGYKK 20 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 60190300.0 7978300.0 18544000.0 33668000.0 True False 12103664.391858844 15234678.315066693 27013505.0427914 1.0 1.2586831410588208 2.231845180783532 23.528940554655303 -6.946285307308802 0.5982374973397924 0.9889949029126284 2.5511994146974186 0.9988765902048217 0.01777577504545147 0.08501255473192687 0.04240625041827315 0.018275863086720207 0.08173544177681467 1.1316566835128494e-07 6.946285307308802 1.5622045117847903 up IEEVPELPLVVEDK(ub)VEGYKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEEVPELPLVVEDKVEGYKK 20 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 34776600.0 1096300.0 3370300.0 30310000.0 True False 1501631.7363935239 3221389.0019083014 23151402.25404473 1.0 2.1452590031462218 15.417496642450807 20.518099615717556 -6.923902153122691 0.7952411860032598 0.7462531569101949 17.76249093051302 0.9951981321578298 0.45341846085113907 0.09593007013481553 0.09411039104048001 0.39896845370029027 1.243594420054875 1.1915104259946727e-07 6.923902153122691 17.016237773602825 up IEEVPELPLVVEDK(ub)VEGYKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEEVPELPLVVEDKVEGYKK 20 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 147436300.0 7978300.0 16998000.0 122460000.0 True False 10328066.625804763 16052046.357557138 100173536.54570921 1.0 1.5542159959978339 9.699156693608536 23.300066876747753 -6.920676804496045 0.8196920619478969 0.8246330416929725 11.033266007179508 0.9943668308125975 0.29846402263224675 0.09777528652040633 0.10356302002526593 0.2580827548742107 0.7781531189948314 1.200392284948338e-07 6.920676804496045 10.208632965486535 up IEEVPELPLVVEDKVEGYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEEVPELPLVVEDKVEGYK 19 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 13929300.0 4848200.0 2268700.0 6812400.0 False True 4694296.544770514 3174603.741114208 5028028.072380708 1.0 0.6762682567744348 1.0710929794117872 22.162477550971463 -6.688790692587765 1.8705333559831074 0.7968109636762053 1.0697147946388859 0.3648112058052082 0.1369497008596989 0.4192957749316913 2.8433969337570266 0.05858858930808897 0.1528118360868975 2.0474311545910204e-07 6.688790692587765 0.27290383096268056 IEEVPELPLVVEDKVEGYK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEEVPELPLVVEDKVEGYKK 20 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 32543000.0 3336900.0 3901400.0 25304700.0 True False 3230971.93602671 5459249.365532226 18676639.94527217 1.0 1.689661647833977 5.780502064106376 21.623536788843907 -6.936077520032085 0.695093998506828 0.9495168975723961 6.7670371744876485 0.9976037145880896 0.10328187940371843 0.0896024569026739 0.06310469477008503 0.0977675214311956 0.3585941193518874 1.158570536946002e-07 6.936077520032085 5.8175202769152525 IEEVPELPLVVEDKVEGYK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEEVPELPLVVEDKVEGYKK 20 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 42526300.0 3336900.0 3678900.0 35510500.0 True False 2774780.199734815 3659081.0354955215 42935581.36799905 1.0 1.3186922105921106 15.47350718882252 21.403942064278183 -6.91175344389536 0.8837014633732455 0.5856677164751786 17.373134098057445 0.9915667874890092 0.6197790314256477 0.10327010634625786 0.13255944965558653 0.5118620185530962 1.4307552395410554 1.2253116313641387e-07 6.91175344389536 16.787466381582266 up IEFGVDVTTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEFGVDVTTK 10 0 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 5202900.0 0.0 2297000.0 2905900.0 False True 0.0 3214204.0786967585 2144757.614868639 0.0 IEFGVDVTTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEFGVDVTTK 10 0 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 40086300.0 8898300.0 19167000.0 12021000.0 False True 13499371.652868075 15746499.09754546 9645044.081008533 1.0 1.166461632619764 0.7144809646721111 23.68638892079221 -6.807003246174745 1.4269769371566565 1.091049388778649 0.7070966660754104 0.8518698776173281 0.07183416776880505 0.2109275081821963 0.8470394943524621 0.0395878076623797 0.09171022640359212 1.559540845849397e-07 6.807003246174745 -0.38395272270323855 IEFGVDVTTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEFGVDVTTK 10 0 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 18289200.0 8898300.0 9390900.0 0.0 False True 11519024.76171595 8868288.159735447 0.0 1.0 0.7698818557287629 0.0 23.45751524288466 -7.299707284013613 0.8187861208711326 0.988995253030152 1.6929206091502073e-18 0.9882891556963033 0.04627479915408695 0.10386453252764383 0.1374999390337054 0.03945489389382684 0.06982289625124465 5.015251494256379e-08 7.299707284013613 -0.988995253030152 down IEGDMIVCAAYAHELPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEGDMIVCAAYAHELPK 17 0 P46777;A0A2R8Y6J3;Q5T7N0;A0A2R8Y4A2 P46777 RPL5 60S ribosomal protein L5 0 18056800.0 2959500.0 9278400.0 5818900.0 False True 3879933.1598387677 7894098.886919929 5216816.046830177 1.0 2.0345966184757605 1.3445633808410669 21.887600368437674 -10.252448063975535 4.954187324877379 0.9998635196240607 1.6895799996589698 0.571106720354318 0.28170488962956053 0.00042474311847960075 6.409054217668563e-05 0.2728128930808255 0.09091986217309493 5.591803943428058e-11 10.252448063975535 0.689716480034909 IEGDMIVCAAYAHELPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEGDMIVCAAYAHELPK 17 0 P46777;A0A2R8Y6J3;Q5T7N0;A0A2R8Y4A2 P46777 RPL5 60S ribosomal protein L5 0 96371000.0 11458000.0 71543000.0 13370000.0 False True 17382623.692004375 58775592.6819896 10727413.639720825 1.0 3.381284305718767 0.6171343192946873 24.05114251976808 -6.678759687923791 1.9059963517065739 2.508378267091964 0.6277090539797257 0.3184284506629621 1.0095287764398089 0.4413809331555928 3.098963403445768 0.4251396708340477 1.1231846689719387 2.09527153060326e-07 6.678759687923791 -1.8806692131122384 IEGDMIVCAAYAHELPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEGDMIVCAAYAHELPK 17 0 P46777;A0A2R8Y6J3;Q5T7N0;A0A2R8Y4A2 P46777 RPL5 60S ribosomal protein L5 0 14173800.0 2959500.0 5581500.0 5632800.0 False True 4053707.127480282 5334890.874447734 4302448.651157481 1.0 1.3160523705035927 1.0613614935304447 21.950810429960566 -10.758550695376808 8.356339009351847 0.998188010802594 1.188706932017017 0.42261963819503157 0.10397711512102971 0.0035394503477135385 0.00010226921514718286 0.1015191134064032 0.03355846960420327 1.743609813282229e-11 10.758550695376808 0.19051892121442293 IEGDMIVCAAYAHELPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEGDMIVCAAYAHELPK 17 0 P46777;A0A2R8Y6J3;Q5T7N0;A0A2R8Y4A2 P46777 RPL5 60S ribosomal protein L5 0 36276000.0 11458000.0 12306000.0 12512000.0 False True 14832606.870946301 11621160.282156592 10234944.383961417 1.0 0.7834873790742609 0.6900300448203304 23.82226884186053 -13.999999999999192 0.11451348449892541 2.037614289493624 0.5292111836663104 0.9997202295623372 0.0021715078788241892 11.987998068276204 0.10339566977644701 2.8535806840069857 0.14272462524443863 1.0000000000018611e-14 13.999999999999192 -1.508403105827314 IEGDNENK(ub)LPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEGDNENKLPR 11 1 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 12376500.0 4355700.0 5692300.0 2328500.0 True False 5710364.880658799 4843031.028411611 2087569.156549186 1.0 0.8481123587767785 0.3655754404801441 22.445151503125654 -6.9501557596663135 0.557131566306663 1.006408250954163 0.18433161894556294 0.9992134459631632 0.007585598913039389 0.08342327015019185 0.0357040679575026 0.008159790559542645 0.04008735701033536 1.1216161146653713e-07 6.9501557596663135 -0.8220766320086 down IEGDNENK(ub)LPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEGDNENKLPR 11 1 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 15690550.0 6411000.0 8439500.0 840050.0 True False 6207486.314203985 11809436.361411097 620015.7040401942 1.0 1.9024506480809658 0.09988192847424773 22.56557774498496 -6.77058919096146 1.572182191639961 1.5172393829361768 0.08951700892770142 0.732793751588728 0.38039923172445916 0.2654897248517392 1.2951641019863824 0.1907052432548186 0.4537156503075711 1.6959412714100932e-07 6.77058919096146 -1.4277223740084755 IEGDNENK(ub)LPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEGDNENKLPR 11 1 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 32065400.0 12276000.0 10201000.0 9588400.0 True False 18623589.49581476 8380551.849223216 7693248.537254978 1.0 0.4499965944323762 0.41309160830589964 24.150627827802367 -13.999999999999998 0.38383487826017854 9.361254799879829 0.41006465071616793 0.9998136272975721 0.0036640928764604857 24.52700840431525 0.20243076248749922 169.72445733726855 0.009889236172754745 1.0000000000000041e-14 13.999999999999998 -8.951190149163661 IEGDNENK(ub)LPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEGDNENKLPR 11 1 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 12097200.0 4355700.0 4664200.0 3077300.0 True False 5966119.998366568 4458120.221553191 2350505.1189829027 1.0 0.7472394492188819 0.39397550160346 22.508361564648546 -6.966405422757373 0.3330519336951931 1.0415356441211514 0.0880617656197162 0.9999392521143171 0.0019371349589333673 0.07748724445573676 0.013195755785629468 0.005100124989659523 0.030737850514963434 1.0804248817126661e-07 6.966405422757373 -0.9534738785014352 down IEGDNENK(ub)LPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEGDNENKLPR 11 1 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 17732300.0 6411000.0 9323300.0 1998000.0 True False 5331030.555455643 9273073.532369833 2415772.5622917716 1.0 1.7394523321349196 0.45315301369254596 22.345983020419236 -6.750797507080981 1.6467756616020248 1.434384502518604 0.4504209588584615 0.6524496984206729 0.3107363728213028 0.298652832358709 1.5937145157569899 0.14904132679073612 0.36154629121582904 1.775016902349187e-07 6.750797507080981 -0.9839635436601424 IEGDNENK(ub)LPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEGDNENKLPR 11 1 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 34208700.0 12276000.0 12794000.0 9138700.0 True False 15891523.996136902 12082002.653170118 7475550.370980519 1.0 0.76027967211371 0.4704111684189486 23.921754149894817 -6.968590841425331 0.28987345442301443 1.0567241387607214 0.1650125251346924 0.9999692096201693 0.0012014723070148954 0.07676264560213622 0.010658409339256743 0.005067595789626961 0.02629042759242349 1.0750017186446085e-07 6.968590841425331 -0.891711613626029 down IEGEMQVPDVDIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEGEMQVPDVDIR 13 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 14264100.0 3265600.0 5097000.0 5901500.0 False True 4281233.22411538 4336547.467950386 5290869.391185328 1.0 1.012920165975409 1.2358283499676816 22.029594999138315 -6.918809008062671 0.8335205029114033 0.9948673530564633 1.2708067476821645 0.9938434552650476 0.008493987899840572 0.09887760616638304 0.10928563135454807 0.0072726507094258135 0.021542821026865902 1.2055660018241457e-07 6.918809008062671 0.27593939462570116 IEGEMQVPDVDIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEGEMQVPDVDIR 13 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 15178800.0 5712300.0 0.0 9466500.0 False True 5530966.163254931 0.0 6986939.661087431 1.0 0.0 1.263240355275591 22.39910008544172 -6.695723635926103 1.8461796615148331 0.37645980524444267 1.2591917609874033 0.39732161269527366 0.42245066798644365 0.4044642022409962 2.677043008106483 0.1827655739149867 0.47251143534484713 2.0150060947159182e-07 6.695723635926103 0.8827319557429606 IEGETK(ub)ESNYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEGETKESNYAK 12 1 Q99996-6;Q99996-1;Q99996;Q99996-3;Q99996-5;A0A0A0MRF6;H7BYL6 Q99996-6 AKAP9 A-kinase anchor protein 9 1 2420890.0 962390.0 1458500.0 0.0 True False 1245832.8265430266 1377333.1928754593 0.0 1.0 1.1055521764483633 0.0 20.248679061042314 -6.957330418768007 1.1911292255950667 1.0613770770069157 8.884510625727463e-20 0.9741584217606201 0.08007929502371307 0.1047103798961489 0.2946899862885474 0.05603022111903005 0.10584870272538854 1.1032389372178196e-07 6.957330418768007 -1.0613770770069157 down IEGFTNVK(ub)ELYGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEGFTNVKELYGK 13 1 O14908 O14908 GIPC1 PDZ domain-containing protein GIPC1 1 31036600.0 14579000.0 10939000.0 5518600.0 True False 14116197.625141129 15306999.746131409 4073113.1055487306 1.0 1.0843571443679314 0.2885418023827085 23.750848197147626 -6.8806959998876165 1.0759529112311432 1.052774164382856 0.2313944202813277 0.9742406818112925 0.057286721452014584 0.12701337676508428 0.2685991904011082 0.04098936082004399 0.0992967580004417 1.3161457936212227e-07 6.8806959998876165 -0.8213797441015284 down IEGFTNVK(ub)ELYGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEGFTNVKELYGK 13 1 O14908 O14908 GIPC1 PDZ domain-containing protein GIPC1 1 70709000.0 28935000.0 20813000.0 20961000.0 True False 43896510.43185079 17098757.53728878 16818049.16246733 1.0 0.38952430088570605 0.3831295243519939 25.387602920993505 IEGFTNVK(ub)ELYGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEGFTNVKELYGK 13 1 O14908 O14908 GIPC1 PDZ domain-containing protein GIPC1 1 77703000.0 28935000.0 28567000.0 20201000.0 True False 37456927.89412035 26977221.337588828 16524625.279763805 1.0 0.720219805902007 0.4411633897599405 25.158729243085954 -6.971157720457333 0.22886377213580764 1.1151164095445625 0.03830428239009283 0.9999900552403174 0.0007194365674631724 0.07592889471859282 0.007672960596953305 0.007230667000989001 0.02777733594597051 1.0686667066387134e-07 6.971157720457333 -1.0768121271544697 down IEGLLAAFPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEGLLAAFPK 10 0 P48444;B0YIW6;Q6P1Q5;E9PK34 P48444 ARCN1 Coatomer subunit delta 0 8243100.0 1780000.0 2750100.0 3713000.0 False True 2333597.2375445203 2339795.7998058414 3328814.3776109684 1.0 1.0026562262594394 1.426473396546203 21.15412415284672 -6.90827446388477 0.9073998881802217 0.9861507918045759 1.4792711647588954 0.9902539979382345 0.0197856670606128 0.10557052317815491 0.1450368100792628 0.01606180903336194 0.043825568525985 1.235166590536737e-07 6.90827446388477 0.49312037295431954 IEGLLAAFPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEGLLAAFPK 10 0 P48444;B0YIW6;Q6P1Q5;E9PK34 P48444 ARCN1 Coatomer subunit delta 0 6979300.0 1780000.0 2310600.0 2888700.0 False True 2438114.1026913007 2208510.051867588 2206448.5546439765 1.0 0.9058271921850313 0.9049816627566358 21.21733421436961 IEGLLAAFPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEGLLAAFPK 10 0 P48444;B0YIW6;Q6P1Q5;E9PK34 P48444 ARCN1 Coatomer subunit delta 0 2517500.0 1734100.0 783400.0 0.0 False True 1441980.983655534 779179.6687072745 0.0 1.0 0.5403536367948442 0.0 20.459620708267156 -7.809428798212805 0.6188226077653053 1.0048812707225911 2.923404742949511e-19 0.9881223798233906 0.044541009046612304 0.11650791647102633 0.15616795277005263 0.0434757122818756 0.07782052903468864 1.5508550258019592e-08 7.809428798212805 -1.0048812707225911 down IEHLYK(ub)NPQAHIEGNMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEHLYKNPQAHIEGNMK 17 1 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 1 23686900.0 1502700.0 2787200.0 19397000.0 True False 1454997.611036395 3900143.495055983 14316343.802473245 1.0 2.6805153943022013 9.839427703441872 20.47258535369569 -6.943430494150886 0.6268361648774059 0.9218857023623781 11.981797258473218 0.9985795960015332 0.14444956842908624 0.08623587182994115 0.047740297796373975 0.1445776607943386 0.6074601440890974 1.1391200756325673e-07 6.943430494150886 11.05991155611084 IEHLYK(ub)NPQAHIEGNMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEHLYKNPQAHIEGNMK 17 1 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 1 9706400.0 2003300.0 1384800.0 6318300.0 True False 2743974.1471469034 1323614.9570787798 4826047.669473132 1.0 0.4823715115738362 1.7587802984554728 21.387835458284368 -6.796623582387481 1.4697608638469428 0.7131683258845761 1.7749465505429334 0.8220795245339463 0.2211034558997617 0.22561233678497492 0.9625110886962704 0.11836961695941853 0.2758571176059875 1.5972629488956305e-07 6.796623582387481 1.0617782246583571 IEHLYK(ub)NPQAHIEGNMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEHLYKNPQAHIEGNMK 17 1 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 1 14306100.0 1502700.0 2479400.0 10324000.0 True False 1249561.6308973941 2466042.9800776327 12482700.667217363 1.0 1.9735264904913907 9.989663861759821 20.252990629129965 -6.929563128143078 0.7503715337239184 0.8761032854596598 11.617164712713553 0.9964516610926007 0.23993735288740545 0.09286527344943139 0.07879664721320498 0.21802920286138644 0.7270722588119526 1.1760800197126369e-07 6.929563128143078 10.741061427253893 IEHQTITTPSK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEHQTITTPSKK 12 1 P40938;P40938-2 P40938 RFC3 Replication factor C subunit 3 1 2724760.0 723030.0 1332600.0 669130.0 True False 601231.4806599739 1325421.0192996094 809041.9892924397 1.0 2.2045103457401964 1.3456414298272463 19.19756102561222 -10.186170331678365 4.851895419441462 0.9999127575634058 1.7750758877859887 0.520581199691493 0.350631766661834 246152347.0121457 39.566571810154876 239915.9700198138 0.1200305799854319 6.51372873441529e-11 10.186170331678365 0.7751631302225829 IEIHYAK(ub)TAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEIHYAKTAK 10 1 E9PHA2;Q15003;Q15003-2;H7C415 E9PHA2 NCAPH Condensin complex subunit 2 1 10154900.0 4562300.0 3331800.0 2260800.0 True False 5981219.481376053 2834708.4272546833 2026874.1031249308 1.0 0.4739348616249949 0.3388730524663214 22.51200822772246 -13.999999999999998 0.19090952663815366 3.82894262708367 0.24286011310532277 0.9994889331805729 0.0064475574540722586 12.36566875057602 0.13856087418294646 13.01702113839949 0.09221639972948756 1.0000000000000041e-14 13.999999999999998 -3.586082513978347 IEIHYAK(ub)TAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEIHYAKTAK 10 1 E9PHA2;Q15003;Q15003-2;H7C415 E9PHA2 NCAPH Condensin complex subunit 2 1 25400100.0 7792300.0 7084800.0 10523000.0 True False 11821488.793437405 5820462.0862049395 8443124.437605258 1.0 0.49236286460264783 0.7142183683574935 23.49490840358926 -10.305671328831945 5.739653179383252 1.000041045609414 0.6032906164800688 0.8100041988669142 0.09057213013792437 4.757658451890126e-05 5.7554382480292335e-06 0.08770513527465988 0.029232029304557938 4.9468491960922844e-11 10.305671328831945 -0.3967504291293452 IEIHYAK(ub)TAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEIHYAKTAK 10 1 E9PHA2;Q15003;Q15003-2;H7C415 E9PHA2 NCAPH Condensin complex subunit 2 1 11620700.0 4562300.0 4455800.0 2602600.0 True False 6249105.601521646 4258928.022639827 1987919.482229522 1.0 0.6815260125549464 0.31811264027054803 22.575218289245353 -7.191728701314662 0.30556318526667137 1.0682446471530673 1.2000745066599485e-16 0.99991745567452 0.0025310087944736457 0.08844194594788875 0.016249081166793453 0.009387638793981749 0.039672981764239945 6.430893222460058e-08 7.191728701314662 -1.068244647153067 down IEIHYAK(ub)TAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEIHYAKTAK 10 1 E9PHA2;Q15003;Q15003-2;H7C415 E9PHA2 NCAPH Condensin complex subunit 2 1 18042200.0 6300700.0 9001100.0 2740400.0 True False 5239311.218337124 8952609.287721537 3313404.9698220063 1.0 1.708737831108066 0.6324123213420465 22.32094573085703 -6.729105024310924 1.726565049901107 1.4269393133206811 0.633164406905165 0.5550945778620131 0.2979576017023038 0.33791109650189505 1.9730394798647712 0.13678231310110997 0.33975119728504494 1.8659284036318624e-07 6.729105024310924 -0.7937749064155162 IEILEK(ub)TTTIYEEDKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEILEKTTTIYEEDKR 16 2 H7BYN4;Q02241-3;Q02241-2;Q02241;A0A2U3TZL8 H7BYN4 KIF23 Kinesin-like protein;Kinesin-like protein KIF23 1 5786100.0 2378800.0 2070600.0 1336700.0 True False 3258306.644652842 1979114.0454414517 1020998.9902006468 1.0 0.6074057052577743 0.3133526403588173 21.63569095400469 -7.9073449195616154 0.22950724238155198 1.1944886414132898 1.915820063168393e-14 0.9997620697228565 0.004338786147829414 0.11300802276962837 0.03760158525750844 0.06221910491523298 0.09378828929327909 1.2378131166455264e-08 7.9073449195616154 -1.1944886414132707 down IEINFPAEYPFKPPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEINFPAEYPFKPPK 15 1 P68036-2;P68036;P68036-3 P68036-2 UBE2L3 Ubiquitin-conjugating enzyme E2 L3 0 14241100.0 3722600.0 4806600.0 5711900.0 False True 4880364.649709682 4089474.0159800574 5120887.380413696 1.0 0.8379443565192055 1.0492837621709932 22.21855751602087 -6.701778462167519 1.8241144877826228 0.8995507384162726 1.0486860037602872 0.42626966835102853 0.06838302298364674 0.3918033745112984 2.5356688542112207 0.02989087327680315 0.07671489241282263 1.9871083021076232e-07 6.701778462167519 0.14913526534401456 IEINFPAEYPFKPPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEINFPAEYPFKPPK 15 1 P68036-2;P68036;P68036-3 P68036-2 UBE2L3 Ubiquitin-conjugating enzyme E2 L3 0 16273800.0 3722600.0 5665900.0 6885300.0 False True 5098945.8194823805 5415561.803374256 5259133.947204686 1.0 1.0620944005096364 1.0314159305459274 22.28176757754376 -10.138326027122128 4.451428398656003 0.999993234648035 1.04675516552752 0.7559143954631231 0.012524432922563486 8.485304780007929e-07 1.6425165393552176e-07 0.012128500401496402 0.004042243343330574 7.272336614812801e-11 10.138326027122128 0.04676193087948499 IEINFPAEYPFKPPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEINFPAEYPFKPPK 15 1 P68036-2;P68036;P68036-3 P68036-2 UBE2L3 Ubiquitin-conjugating enzyme E2 L3 0 11014700.0 5899800.0 2684100.0 2430800.0 False True 4905945.105455803 2669640.220547865 2939069.0412506685 1.0 0.5441643074193823 0.5990831487254492 22.226099660429277 -10.041489057707901 4.9609116094808305 1.0000075290008443 0.5716237280695571 0.9878232205169285 0.022420523090492982 34640991873.8008 6693082152.909474 3090443.26238614 0.007676259304233422 9.088891987482335e-11 10.041489057707901 -0.42838380093128725 IEIPIHIVPHVTIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEIPIHIVPHVTIGK 15 0 A0A087WZR3;P46736-2;P46736-3;H9KVA9;A0A0D9SF50;P46736;P46736-4;X6RJS7 A0A087WZR3;H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 0 20055600.0 4410300.0 9078600.0 6566700.0 False True 5781946.009405955 7724108.268105631 5887240.876234296 1.0 1.335901140470735 1.0182109737201022 22.4631237066196 -10.252109484576865 4.353725897313178 0.9999018250969708 1.177056057098776 0.29285910046254393 0.1296964674844549 0.0001236605763599966 2.1242625937397645e-05 0.12564757220910386 0.04185935488418849 5.59616505758296e-11 10.252109484576865 0.17715423200180525 IEIPIHIVPHVTIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEIPIHIVPHVTIGK 15 0 A0A087WZR3;P46736-2;P46736-3;H9KVA9;A0A0D9SF50;P46736;P46736-4;X6RJS7 A0A087WZR3;H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 0 15258900.0 4422100.0 3452900.0 7383900.0 False True 4281722.856035155 4831660.976635619 5449835.077748215 1.0 1.128438513909259 1.2728135988686393 22.029759986447996 -6.969608905684321 0.2673709780454097 0.9629460692659434 1.4426311577585038 0.9999791636994929 0.0005086506193449432 0.0764298922980467 0.009483742132069144 0.002876336119775532 0.013476891172851137 1.0724846729165926e-07 6.969608905684321 0.4796850884925604 IEIPIHIVPHVTIGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEIPIHIVPHVTIGK 15 0 A0A087WZR3;P46736-2;P46736-3;H9KVA9;A0A0D9SF50;P46736;P46736-4;X6RJS7 A0A087WZR3;H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 0 25657400.0 6841500.0 9278600.0 9537300.0 False True 10379055.680646535 7622761.335967315 7652248.47465291 1.0 0.7344368862170394 0.7372779094847512 23.307171852914795 -10.46898774794057 6.025489167818239 1.0001668129947208 0.7358573978508953 0.9999132425013868 0.001159842892211557 2.6007280754770267e-06 2.2919462145550836e-07 0.001123716225556493 0.00037433768381268354 3.39634854033169e-11 10.46898774794057 -0.26430941514382544 IEIPIHIVPHVTIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEIPIHIVPHVTIGK 15 0 A0A087WZR3;P46736-2;P46736-3;H9KVA9;A0A0D9SF50;P46736;P46736-4;X6RJS7 A0A087WZR3;H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 0 32422300.0 4410300.0 14437000.0 13575000.0 False True 6040907.093876092 13799125.603225267 10368864.585900933 1.0 2.2842803884890053 1.716441657646459 22.526333768142493 -10.34340882274194 6.34828805664953 0.9999320982177907 2.0003610230676983 0.8053759813310284 0.23181919112563978 0.00022282479743785137 2.304655560428127e-05 0.2244729792141138 0.07481932221340633 4.5351450015905734e-11 10.34340882274194 1.0004289248499076 IEIPIHIVPHVTIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEIPIHIVPHVTIGK 15 0 A0A087WZR3;P46736-2;P46736-3;H9KVA9;A0A0D9SF50;P46736;P46736-4;X6RJS7 A0A087WZR3;H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 0 11415800.0 4422100.0 4094300.0 2899400.0 False True 3677172.082246193 4072243.1932450826 3505651.1346890694 1.0 1.1074388421761217 0.9533552023890188 21.810165261882272 -6.7192139336962 1.762042299812694 1.0654193820315279 0.953604496864626 0.5088258331606983 0.045215144653769586 0.35686005551847927 2.164903289161531 0.020377807316193156 0.05120523707812041 1.9089126955001627e-07 6.7192139336962 -0.11181488516690186 IEIPIHIVPHVTIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEIPIHIVPHVTIGK 15 0 A0A087WZR3;P46736-2;P46736-3;H9KVA9;A0A0D9SF50;P46736;P46736-4;X6RJS7 A0A087WZR3;H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 0 21528400.0 6841500.0 6741700.0 7945200.0 False True 8856456.616126651 6366518.468569412 6499255.124636367 1.0 0.7188561683886837 0.7338437262597691 23.078298175007244 -10.40244402510638 8.869401479791822 1.000001371613304 0.7263499473265179 0.9977553100002655 0.006118644879098833 1.6595402145974847e-07 1.1177657314020358e-08 0.005924382086962537 0.0019747841431755936 3.958730844244399e-11 10.40244402510638 -0.2736514242867861 IEK(ub)EQSKQAVEMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEKEQSKQAVEMK 13 2 B2R5W2;P07910-2;G3V4W0;B4DY08;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 11952500.0 2347900.0 6562000.0 3042600.0 True False 3561935.954482202 5390959.830859992 2441228.7763810433 1.0 1.5134915112879044 0.6853657133585167 21.76423014556674 -6.7389842010724 1.6902923832187173 1.3058838661021877 0.6849751676283001 0.6004180764300346 0.2157534355668726 0.31966043739627675 1.7928512931248126 0.10099154715327435 0.24811284860086164 1.8239620538886548e-07 6.7389842010724 -0.6209086984738875 IEK(ub)IGEGTYGVVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEKIGEGTYGVVYK 14 1 P06493;A0A024QZP7;P06493-2;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 14307400.0 2625000.0 4209700.0 7472700.0 True False 2541670.811852353 5890655.163295482 5515375.693805322 1.0 2.317631038538154 2.1699803405248033 21.277345759044838 -10.366379638336584 6.021319064967477 0.9998096634872072 2.243805689531479 0.9895416951646784 0.06027814504974943 0.00015404189432742242 1.6209643776831157e-05 0.058372583413581196 0.019454687659829113 4.3015043028115816e-11 10.366379638336584 1.2439960260442717 IEK(ub)IGEGTYGVVYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEKIGEGTYGVVYK 14 1 P06493;A0A024QZP7;P06493-2;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 9578100.0 2625000.0 3792700.0 3160400.0 True False 2182803.807217445 3772267.9723079945 3821225.0279614194 1.0 1.7281754593953806 1.750603977932662 21.057751034479114 -11.217301837777987 0.5799637577519341 2.1090395494920853e-06 1.7481708349406089 0.9999209938714468 0.003099178498449704 3.4850680915400125 0.28632447823403845 4.516047924584351 0.004008280009841784 6.063147899937864e-12 11.217301837777987 1.7481687259010594 IEK(ub)IGEGTYGVVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEKIGEGTYGVVYK 14 1 P06493;A0A024QZP7;P06493-2;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 66058800.0 3416500.0 5187300.0 57455000.0 True False 4422726.599283298 4898622.194996833 46998779.538083665 1.0 1.1076023093515783 10.626652695579196 22.07650463090297 -6.9093675833567385 0.9000085840046622 0.6993424760075593 11.840424261026003 0.9906812269198834 0.43564728399693115 0.10483832682285192 0.14103833247927067 0.35555853865100073 0.977282178785607 1.2320615847759443e-07 6.9093675833567385 11.141081785018443 up IEKEQSK(ub)QAVEMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEKEQSKQAVEMK 13 2 B2R5W2;P07910-2;G3V4W0;B4DY08;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 4471400.0 683400.0 2731600.0 1056400.0 True False 1036767.7632323097 2244124.6379117887 847602.0769634313 1.0 2.164539366960376 0.8175428548442514 19.98366133487779 -6.678042287801706 1.9089565298105584 1.7381230397273633 0.8227640583625302 0.3150965930854045 0.4937748479392894 0.4429118367588322 3.118861528422143 0.20768832304694018 0.5491188945777651 2.0987355171484377e-07 6.678042287801706 -0.9153589813648331 IEKEQSK(ub)QAVEMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEKEQSKQAVEMK 13 2 B2R5W2;P07910-2;G3V4W0;B4DY08;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 7768200.0 683400.0 5944600.0 1140200.0 True False 884674.7718279554 5613777.78427662 932695.299439961 1.0 6.345583668761319 1.0542804306635571 19.75478765697024 -6.643793859461297 2.0305651615717246 4.485559325689542 1.0763216498322035 0.16938316872939052 2.2850495206558357 0.5238654700874767 4.1326977886039025 0.9148958065266398 2.530750755711773 2.270942512892366e-07 6.643793859461297 -3.409237675857339 IELFADVVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IELFADVVPK 10 0 C9JQD4;O43447;A6NM32 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 0 8949600.0 2414900.0 2911000.0 3623700.0 False True 3165957.2859248626 2476690.1469891258 3248754.2849848783 1.0 0.782287922202847 1.0261522792578766 21.59421036055414 -6.671308036849324 1.9331001477369694 0.8611906062161129 1.0251651318159802 0.28475893052224643 0.09245168879070823 0.4580824275685521 3.3015349952360067 0.03848859865893117 0.1026431904634719 2.1315325212140903e-07 6.671308036849324 0.16397452559986736 IELFADVVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IELFADVVPK 10 0 C9JQD4;O43447;A6NM32 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 0 10595800.0 3479800.0 1824900.0 5291100.0 False True 3369335.6537462156 2553592.0867277775 3905202.180402441 1.0 0.7578918662759382 1.1590421916143674 21.68403272644932 -6.743303999546446 1.6745444752212313 0.8564972261514684 1.1594521849307655 0.6196481696801164 0.10171989453864803 0.31189964992241026 1.71847686751934 0.04803043183683283 0.11744015316645769 1.8059095741837113e-07 6.743303999546446 0.3029549587792971 IELFADVVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IELFADVVPK 10 0 C9JQD4;O43447;A6NM32 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 0 10342700.0 2414900.0 3821500.0 4106300.0 False True 3307753.7902186597 3652653.4939894318 3136476.5119031267 1.0 1.1042700653206636 0.9482194597366902 21.65742042207703 -6.726587961118621 1.7354643044966136 1.0629835192422747 0.9483642909094 0.543553132190581 0.043845357186777185 0.3426297625723314 2.020010687531743 0.020033436157577703 0.04990872383465677 1.8767742618469477e-07 6.726587961118621 -0.11461922833287475 IELFADVVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IELFADVVPK 10 0 C9JQD4;O43447;A6NM32 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 0 6913000.0 3479800.0 1971600.0 1461600.0 False True 2893607.8812781954 1960978.5994680405 1767213.8023251537 1.0 0.6776932742531154 0.6107302284318223 21.464438001883597 -13.999999999995191 0.22087100539427712 2.952397223047922 0.5752091202734021 0.9994987792566828 0.00380446057260656 13.02352179327542 0.14887702659295898 11.095443485479723 0.036847420997444924 1.0000000000110721e-14 13.999999999995191 -2.37718810277452 IELHGK(ub)PIEVEHSVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IELHGKPIEVEHSVPK 16 1 O00425;F8WD15 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 22941200.0 6437300.0 11098000.0 5405900.0 True False 8439362.63890188 9442221.659665186 4846549.325054432 1.0 1.1188311325953162 0.574279069691104 23.00870261654849 -6.84953260805809 1.2373101324823415 1.0633884319616818 0.5527010835709395 0.9396298586420727 0.05744159998073179 0.15796900330598768 0.4656127661229751 0.03633133961196057 0.08404990797853004 1.414058549568702e-07 6.84953260805809 -0.5106873483907423 IELHGK(ub)PIEVEHSVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IELHGKPIEVEHSVPK 16 1 O00425;F8WD15 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 20651900.0 5444600.0 5265500.0 9941800.0 True False 5271764.153223369 7368041.609219749 7337744.332393065 1.0 1.3976424959592761 1.3918954109330692 22.329854398208443 -10.132615526169166 4.846279230522118 0.9999752966626116 1.3947689534483325 0.9998410706407287 0.0023462376445475483 1638458.140357207 0.02228397467832152 451.6625462931237 0.0008031795508669903 7.368591382243899e-11 10.132615526169166 0.39479365678572087 IELHGK(ub)PIEVEHSVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IELHGKPIEVEHSVPK 16 1 O00425;F8WD15 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 19567700.0 5444600.0 10096000.0 4027100.0 True False 4527426.136676618 10041610.844100906 4869147.990793399 1.0 2.2179513350320508 1.0754781732049687 22.11025967364272 -6.631038936512129 2.076282783764884 1.8017739591166702 1.0800528893400907 0.1213989921560451 0.5222937003084697 0.5562900311769434 4.57127543067662 0.20562590357645685 0.5786897876717267 2.3386275604659253e-07 6.631038936512129 -0.7217210697765795 IELHGK(ub)PIEVEHSVPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IELHGKPIEVEHSVPK 16 1 O00425;F8WD15 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 71325000.0 13850000.0 21410000.0 36065000.0 True False 17929098.02431545 20218514.67909742 29501540.058149625 1.0 1.1276927959051293 1.6454558962274413 24.095799575252247 -6.9445630389289255 0.6156577799854807 0.9943123719672113 1.806062528450355 0.9987024763253074 0.010052973095942535 0.0857453710230714 0.04558493517072961 0.010164621777219874 0.043747738985821835 1.1361533701979624e-07 6.9445630389289255 0.8117501564831437 IELVVAPAGVTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IELVVAPAGVTLK 13 0 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 9356800.0 5250000.0 3077100.0 1029700.0 False True 6882800.841072318 2618008.674441857 923156.5215798571 1.0 0.38036966852494014 0.134125124770577 22.714564334433806 -9.759656629434033 0.25290308791384225 1.4849661951851454 2.770165832894148e-20 0.9990503622561705 0.011225806592485368 1.185013944466536 0.10915354899056068 0.5365217607511253 0.10609705228683346 1.7391753468066021e-10 9.759656629434033 -1.4849661951851454 IELVVAPAGVTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IELVVAPAGVTLK 13 0 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 40503300.0 15326000.0 7817300.0 17360000.0 False True 14839484.519028243 10938788.656680949 12812895.21116335 1.0 0.7371407438482419 0.8634326343838793 23.82293764196822 -10.082183095526526 4.6666910315689325 1.000010404927058 0.8002866891114906 0.7692810733179906 0.05155844842627094 12642387.97375652 27313330.17788029 812.8663161313759 0.017649827909839128 8.275931826360565e-11 10.082183095526526 -0.19972371581556736 IELVVAPAGVTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IELVVAPAGVTLK 13 0 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 106121000.0 25684000.0 46855000.0 33582000.0 False True 38964505.75191486 38493359.17021411 26944502.980486516 1.0 0.9879083136662757 0.6915140449115632 25.21565718069962 -6.915485387397067 0.8575327254778272 1.0076628810403039 0.648349986870384 0.9928323745957698 0.012077607170274694 0.10090162240894415 0.11991466393897898 0.010164550370406467 0.029249444812949648 1.214827494794779e-07 6.915485387397067 -0.35931289416991985 IELVVAPAGVTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IELVVAPAGVTLK 13 0 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 18713400.0 5250000.0 4520200.0 8943200.0 False True 7191066.875915349 4320482.617697511 6831000.350985568 1.0 0.6008124652779783 0.949928636300723 22.777774395956698 -10.199662010944552 7.697086404708295 1.0000001553087903 0.7753705507893507 0.35566646796615653 0.14252607999332517 3.798357224000375e-07 3.953994318285276e-08 0.1380003781453568 0.04600009451786455 6.314485772511837e-11 10.199662010944552 -0.22462960451943959 IELVVAPAGVTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IELVVAPAGVTLK 13 0 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 26663500.0 15326000.0 5383900.0 5953600.0 False True 12744248.056919826 5354895.8620795235 7198470.233663812 1.0 0.42018138992295756 0.5648407188492547 23.603342917402497 -10.260502037833948 8.394747318990559 1.000000314432953 0.49251105438635256 0.9425605534371905 0.059056923733810454 3.4753932737199537e-07 3.0653242003345854e-08 0.057181655457679635 0.019060540174940785 5.489059799771177e-11 10.260502037833948 -0.5074892600466004 IELVVAPAGVTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IELVVAPAGVTLK 13 0 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 76090000.0 25684000.0 26164000.0 24242000.0 False True 33248444.307329796 24707950.39999557 19830204.743925218 1.0 0.7431310220595365 0.596425040541026 24.98678350279207 -13.935514680611032 0.06471725442763814 2.548399947855042 1.2145539716070495e-07 0.9999434948970527 0.0012537624192784334 12.056864348877454 0.06574061592236705 2.9390997918234203 0.5463924185529824 1.1600730011244775e-14 13.935514680611032 -2.5483998263996446 IELVVAPAGVTLK(ub)EANEILQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IELVVAPAGVTLKEANEILQR 21 1 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 1 26379000.0 6956100.0 9721700.0 9701200.0 True False 10552912.259028768 7986786.67901121 7783753.567812985 1.0 0.7568324726833529 0.7375929389684283 23.331137854790125 -13.999999999999998 0.3596299275291162 4.174335105249451 0.7352640548371022 0.9997726175238432 0.0018008046424089629 21.657272179907327 0.1937828930631621 52.75498999757003 0.0055586149937136035 1.0000000000000041e-14 13.999999999999998 -3.4390710504123487 IELVVAPAGVTLK(ub)EANEILQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IELVVAPAGVTLKEANEILQR 21 1 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 1 28540600.0 6956100.0 9345500.0 12239000.0 True False 9004808.575230367 8825414.709645262 10011627.582744863 1.0 0.9800779923208399 1.1118090405923746 23.102264176882574 -6.8683601139489125 1.1426691298992355 0.9888361299755434 1.119289340896526 0.9630224027984063 0.011148577533434414 0.13844049972862943 0.3388540868993737 0.007578898001437494 0.017894890315586016 1.354066164521333e-07 6.8683601139489125 0.13045321092098272 IEPADAHVLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEPADAHVLQK 11 0 E7EQ69;Q9GZZ1;C9J5D1;A0A087WWJ2;B0AZT5;Q9GZZ1-2 E7EQ69;Q9GZZ1-2 NAA50 N-alpha-acetyltransferase 50 0 2630930.0 339490.0 310940.0 1980500.0 False True 328713.0757774308 435099.96353067877 1461747.6362735613 1.0 1.323646655982988 4.446880103009044 18.32646932052358 -6.926783848768311 0.772736678157897 0.9464140303143906 5.038526591038596 0.9958674803566461 0.0999123425774905 0.09434256627392884 0.08611631417195056 0.0893402512749676 0.28775811896998305 1.1836305098711863e-07 6.926783848768311 4.092112560724205 up IEPELDGSAQVTSHDASTNGLINFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEPELDGSAQVTSHDASTNGLINFIK 26 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48 P06744 GPI Glucose-6-phosphate isomerase 0 25350300.0 8412300.0 3371000.0 13567000.0 False True 8145256.141160204 4717057.8795327665 10013395.698724257 1.0 0.5791171938346032 1.2293530768325176 22.95752863673933 -6.731967044022295 1.71588159320348 0.7472675738608303 1.229117777199142 0.5683769450806128 0.176904378798454 0.33259425655119773 1.9192671005619715 0.08166828036926763 0.2022182020783625 1.8536722820396474e-07 6.731967044022295 0.48185020333831163 IEPELDGSAQVTSHDASTNGLINFIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEPELDGSAQVTSHDASTNGLINFIK 26 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48 P06744 GPI Glucose-6-phosphate isomerase 0 82970600.0 8862600.0 57993000.0 16115000.0 False True 13445212.142848477 47643696.048622906 12929863.186544593 1.0 3.5435436453090583 0.9616704481246882 23.680589182904725 -6.649638795351753 2.0101080380967735 2.6510330147199386 0.9725979545530443 0.19243453362629037 1.0857209993385508 0.5094485913114583 3.945267714197224 0.4381418780764477 1.2023415267677415 2.2405838673885546e-07 6.649638795351753 -1.6784350601668943 IEPELDGSAQVTSHDASTNGLINFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEPELDGSAQVTSHDASTNGLINFIK 26 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48 P06744 GPI Glucose-6-phosphate isomerase 0 16306800.0 8412300.0 4243800.0 3650700.0 False True 6995200.17807821 4220937.807071658 4414044.49107036 1.0 0.6034048632803065 0.6310104612736086 22.737933912173606 -10.749995148609392 6.908172147767834 1.0071760698490668 0.6172076622771483 0.9961145751037442 0.011269938187998228 0.001252616490987921 4.533178336196233e-05 0.010973674319984882 0.0036373569095753447 1.7782992748462694e-11 10.749995148609392 -0.38996840757191853 IEPGVSVSLVNPQPSNGHFSTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEPGVSVSLVNPQPSNGHFSTK 22 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;Q9P2J5-3 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 8347000.0 4307900.0 1973100.0 2066000.0 False True 3582209.7223283965 1962470.5186703154 2497991.0478952974 1.0 0.5478379745434702 0.6973324404556724 21.772418372450964 -10.408094026110284 5.117734204240583 1.0003528592199824 0.6225852074995504 0.8947167612297942 0.06103086014253798 0.0002459397217046369 2.8444941649810234e-05 0.059147090830611246 0.019697625411386466 3.907562866784807e-11 10.408094026110284 -0.37776765172043203 IEPHTGLLLLSVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEPHTGLLLLSVQK 14 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 25807600.0 9209300.0 9272600.0 7325700.0 False True 12073481.482988073 7889164.22431171 6567706.837076399 1.0 0.6534291070415603 0.5439778779907445 23.525338412715584 -13.999999999999998 0.1613222833592041 2.711669717567805 0.43793641247620063 0.9995329516476968 0.004200769141855395 12.018744733316222 0.12697050115704092 6.436457509193457 0.09681010707317855 1.0000000000000041e-14 13.999999999999998 -2.2737333050916044 IEPHTGLLLLSVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEPHTGLLLLSVQK 14 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 20404600.0 7051900.0 6125400.0 7227300.0 False True 6828041.2945149 8571304.16353901 5334253.315647511 1.0 1.255309362353228 0.7812274539014024 22.70304035282335 -6.760406900119198 1.6107279620414192 1.1482194022799117 0.7794470032020449 0.6927312111923287 0.10739065124874556 0.28222207442948316 1.4431711718282993 0.052600351204796864 0.12636681418634982 1.7361734071654233e-07 6.760406900119198 -0.36877239907786685 IEPHTGLLLLSVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEPHTGLLLLSVQK 14 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 43917200.0 9550200.0 21944000.0 12423000.0 False True 14488351.613141945 18027921.750745457 9967588.604805663 1.0 1.2443045442376532 0.6879725776232795 23.7883901283387 -6.78733802414692 1.5068553861273553 1.1370192159109902 0.6824750204260209 0.7925904329032857 0.10369139964173356 0.2393565397749118 1.073691668617012 0.05417118706642394 0.1270835525593269 1.631781390134339e-07 6.78733802414692 -0.45454419548496927 IEPHTGLLLLSVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEPHTGLLLLSVQK 14 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 35207700.0 9209300.0 8475400.0 17523000.0 False True 12614227.081974726 8100928.803600169 13384428.29751322 1.0 0.6422057214409992 1.0610581378100512 23.588548474238475 -6.680549981332202 1.9005279277758658 0.7737247117055424 1.0594484787029999 0.32642706872182703 0.1516243923335351 0.4372743815711388 3.054327348385025 0.06401425291352666 0.16867766745770507 2.0866519651027043e-07 6.680549981332202 0.2857237669974575 IEPHTGLLLLSVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEPHTGLLLLSVQK 14 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 16411600.0 7051900.0 4037800.0 5321900.0 False True 5863967.302139697 4016047.5699594556 6434684.684314614 1.0 0.6848686841234678 1.0973261535695584 22.483445628257627 -6.702541614486433 1.821985388438848 0.8048000695421575 1.0961509236896114 0.42952201912451593 0.1329607481546574 0.3902824767816334 2.520587007053534 0.05818223544698781 0.14915172810624064 1.983619575524494e-07 6.702541614486433 0.2913508541474539 IEPHTGLLLLSVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEPHTGLLLLSVQK 14 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 32647800.0 9550200.0 15075000.0 8022600.0 False True 12362922.1625861 14236062.998009998 6562569.118827432 1.0 1.1515127904867493 0.5308266955435285 23.55951645043115 -6.842180499196618 1.2722603437806808 1.0805911030986644 0.5095185464478447 0.9281346000179299 0.07083255239991194 0.16626692950058236 0.5218419955568759 0.043640049100497035 0.10060299022421973 1.438200716579549e-07 6.842180499196618 -0.5710725566508197 IEPVFHVMGFSVTGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEPVFHVMGFSVTGR 15 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 27378800.0 6362800.0 9826000.0 11190000.0 False True 9652832.782988792 8072473.529111595 8978291.59524876 1.0 0.8362802620322743 0.9301198722794849 23.202520956496144 -10.201648879079222 4.644123964248671 1.000022898181344 0.8832000671550486 0.6738022633576876 0.03830986046406153 9.084517480714141e-06 1.5616516471447222e-06 0.037100632605230784 0.012364454297335074 6.285663403970247e-11 10.201648879079222 -0.11682283102629532 IEQIQCYSAK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEQIQCYSAKDR 12 1 P52948-6;P52948-2;P52948-5;P52948;H7C3P6;H0YCT1 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 8942800.0 1475700.0 1237000.0 6230100.0 True False 1910322.740395834 1168159.8625896075 5096285.726224268 1.0 0.6114986948998762 2.667761639673659 20.865384964985456 -6.8578248685420835 1.1967000881830847 0.79031788891553 2.7632651285526104 0.9509371288144735 0.19757377998242887 0.14906147770087766 0.4068804768882801 0.12887847449053005 0.3001377896250419 1.387315157979155e-07 6.8578248685420835 1.9729472396370804 up IERPVTVFLQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IERPVTVFLQLK 12 1 Q00653-4;Q00653;Q00653-3 Q00653-4 NFKB2 Nuclear factor NF-kappa-B p100 subunit;Nuclear factor NF-kappa-B p52 subunit 0 4461520.0 705020.0 2017800.0 1738700.0 False True 965684.9464491127 1928646.924027704 1328054.8696505295 1.0 1.9971802720125915 1.3752465279011286 19.881193062740376 -10.176140092912458 4.9357184145196715 0.9999411010283764 1.6862133999583215 0.618784504083562 0.2539033878203831 0.00016457952195602493 2.74714831116859e-05 0.24586188750793 0.08194696604710563 6.665917081406357e-11 10.176140092912458 0.6862722989299451 IESILMSLPLTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IESILMSLPLTAR 13 0 P36551;H0YA22 P36551 CPOX Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial 0 2507180.0 555980.0 1073200.0 878000.0 False True 728895.1641179797 913082.7433008346 787152.9823707059 1.0 1.2526941983566817 1.0799261966886866 19.475351803278006 -10.482730664071951 3.95414949909629 0.998501840037889 1.166310197525597 0.5526768346609974 0.07053224133825566 50957005.358656965 1240.1222665563257 695072.565160878 0.024145034666045707 3.29055637680641e-11 10.482730664071951 0.16780835748770795 IESILMSLPLTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IESILMSLPLTAR 13 0 P36551;H0YA22 P36551 CPOX Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial 0 5336980.0 555980.0 2081400.0 2699600.0 False True 761540.8307945565 1989436.8657306295 2062010.080007232 1.0 2.6123837163858212 2.707681580061605 19.538561864800897 -10.577772710198264 0.5453563488569301 6.876463473250333e-15 2.700196703270234 0.99974958178336 0.01239879111980667 2.0281481271743202 0.26258191523666 2.81180900452774 0.017899157548273693 2.643792034743841e-11 10.577772710198264 2.7001967032702274 IESLSSQLSNLQK(ub)ESR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IESLSSQLSNLQKESR 16 1 P20700;E9PBF6 P20700 LMNB1 Lamin-B1 1 60582000.0 15547000.0 28977000.0 16058000.0 True False 20382267.55736219 24653744.55146135 14396472.19921274 1.0 1.2095682917554615 0.7063233842209402 24.280811226597546 -6.793589844872861 1.4818277953376882 1.1165849559851873 0.7004194090236147 0.8127748628005944 0.08930964277777102 0.230046495815699 0.9977760963940296 0.04742873480666242 0.11076539779680693 1.6084595926413803e-07 6.793589844872861 -0.4161655469615726 IESLSSQLSNLQK(ub)ESR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IESLSSQLSNLQKESR 16 1 P20700;E9PBF6 P20700 LMNB1 Lamin-B1 1 139952000.0 62967000.0 46160000.0 30825000.0 True False 60968147.051393166 64591928.72121993 22751007.769821998 1.0 1.0594372938179029 0.3731621981334616 25.861552364373733 -6.885820722750391 1.0468369532362936 1.040653081116612 0.31876161260121116 0.9780838509951589 0.04595984613111714 0.12259754232937177 0.24220526140882015 0.03362346368927029 0.08265338905507182 1.300706400287286e-07 6.885820722750391 -0.7218914685154008 down IESLSSQLSNLQK(ub)ESR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IESLSSQLSNLQKESR 16 1 P20700;E9PBF6 P20700 LMNB1 Lamin-B1 1 270389000.0 77092000.0 61227000.0 132070000.0 True False 116954200.18013623 50300563.48126552 105966306.6116625 1.0 0.43008770445004235 0.9060496027372266 26.801368433275286 -10.139199050282691 7.594489557906988 1.0000000963173314 0.6680686535936396 0.3933774417442871 0.194310631301678 3.1687176466753687e-07 3.580764145646485e-08 0.18814051582531072 0.06271348658520406 7.257732373901772e-11 10.139199050282691 -0.3319314427236918 IESLSSQLSNLQK(ub)ESR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IESLSSQLSNLQKESR 16 1 P20700;E9PBF6 P20700 LMNB1 Lamin-B1 1 66576000.0 15547000.0 24717000.0 26312000.0 True False 21295146.041877355 23624921.211811267 20097647.51265009 1.0 1.1094040475398648 0.9437665970042018 24.344021288120437 -6.728582736638719 1.7284398474300642 1.0659420925647858 0.9438909086982428 0.5526890691330568 0.04599610670303234 0.3388888500155394 1.9827986991832118 0.021094352109388047 0.05242756157281936 1.868173741027479e-07 6.728582736638719 -0.12205118386654301 IESLSSQLSNLQK(ub)ESR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IESLSSQLSNLQKESR 16 1 P20700;E9PBF6 P20700 LMNB1 Lamin-B1 1 129815000.0 62967000.0 51269000.0 15579000.0 True False 52359850.41107079 50992803.72090024 18836496.87084262 1.0 0.9738913178812003 0.3597507770354496 25.64195763980801 -6.915826638258126 0.8551082328595985 1.0156937840963731 0.26963558619313727 0.992940838638191 0.02485734979983658 0.10069013559824816 0.11879952082578969 0.020956581665304296 0.060474866515408454 1.2138733079099902e-07 6.915826638258126 -0.7460581979032359 down IESLSSQLSNLQK(ub)ESR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IESLSSQLSNLQKESR 16 1 P20700;E9PBF6 P20700 LMNB1 Lamin-B1 1 218887000.0 77092000.0 72736000.0 69059000.0 True False 99797113.71050723 68688177.65991738 56490970.605178304 1.0 0.6882781986978997 0.5660581604498909 26.572494755367735 -13.999999999999044 0.12941151298497078 2.4812800002648663 0.3936112815308186 0.9996482880306824 0.00342634901176312 11.937679240453049 0.11181158689010759 4.500298090837842 0.15332968228928479 1.0000000000022006e-14 13.999999999999044 -2.0876687187340477 IESPHPVDWNDTK(ub)SR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IESPHPVDWNDTKSR 15 1 Q9H2U1-3;Q9H2U1;Q9H2U1-2;A0A0G2JQU7 Q9H2U1-3 DHX36 ATP-dependent RNA helicase DHX36 1 34774800.0 4055800.0 10856000.0 19863000.0 True False 6152945.118697099 8918661.98168485 15937069.343737824 1.0 1.4494948044609568 2.590153013929781 22.55284569377653 -6.955140553830809 0.4992315003653691 0.9770032112289471 3.1117778512238146 0.9995453784462138 0.014270842747860755 0.08148489960869547 0.027910346743836006 0.01676030223777936 0.0940916313715747 1.1088159031619229e-07 6.955140553830809 2.1347746399948675 up IESPHPVDWNDTK(ub)SR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IESPHPVDWNDTKSR 15 1 Q9H2U1-3;Q9H2U1;Q9H2U1-2;A0A0G2JQU7 Q9H2U1-3 DHX36 ATP-dependent RNA helicase DHX36 1 37415100.0 4055800.0 7880300.0 25479000.0 True False 5250313.051770293 7441754.377659582 20842083.4366171 1.0 1.417392506747837 3.9696839466723977 22.32397201586898 -6.935435896610822 0.7007460169127727 0.9678794999060562 4.574400022894321 0.9975027327855824 0.06559657708095264 0.08991210927373224 0.06456425583686937 0.06182834723621796 0.22443972118345662 1.160283465419401e-07 6.935435896610822 3.606520522988265 up IESPLK(ub)HQHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IESPLKHQHR 10 1 P78406;E9PQ57 P78406 RAE1 mRNA export factor 1 3961510.0 1537400.0 1456000.0 968110.0 True False 1488596.0785302138 2037388.3929396917 714532.9483225424 1.0 1.3686643558481866 0.4800045886376689 20.50552090984252 -6.794029346338982 1.480051468879837 1.2049767317321165 0.46945809219496665 0.8141380220147858 0.15716075915271238 0.2294083280882751 0.9925999033728948 0.08355957949952929 0.1950873687459646 1.6068326717357717e-07 6.794029346338982 -0.7355186395371498 down IETELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IETELR 6 0 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;B0AZS6 P63104 YWHAZ 14-3-3 protein zeta/delta 0 6878540.0 1531300.0 910240.0 4437000.0 False True 1482689.719691241 1273703.5788388913 3274816.592853208 1.0 0.8590493087819686 2.2086998711606123 20.499785288021684 -6.881114623546221 1.073614833331864 0.9112963922662036 2.3063970629782204 0.974571266492539 0.09659498388165134 0.12664497143038114 0.26638666432091535 0.06923887240095208 0.1679143148741081 1.3148777500904406e-07 6.881114623546221 1.3951006707120168 up IETLTLAK(ub)NYIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IETLTLAKNYIK 12 1 Q7RTS1 Q7RTS1 BHLHA15 Class A basic helix-loop-helix protein 15 1 5612500.0 2062400.0 1734500.0 1815600.0 True False 1996930.2409006855 2427094.89529801 1340039.8931675204 1.0 1.2154129601459214 0.6710499273941164 20.92935250507828 -6.7993126321183945 1.4584964427814702 1.1189536250806564 0.6636418411938616 0.8302342956229787 0.09222827168301664 0.22172202707376076 0.9311884445240831 0.04974661261022661 0.11575244716045198 1.587403625565036e-07 6.7993126321183945 -0.45531178388679483 IETMLGDVAVAVHPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IETMLGDVAVAVHPK 15 0 P26640;A0A140T936;P26640-2 P26640 VARS Valine--tRNA ligase 0 43860700.0 8479700.0 25045000.0 10336000.0 False True 12864324.849108877 20575524.07252184 8293085.069570272 1.0 1.5994251011118648 0.6446576222882573 23.616872407143962 -6.736999109237334 1.6976852718934703 1.3579008117972566 0.6444610810460647 0.5913245470227433 0.25187846066929576 0.32330873634319973 1.8284365817859398 0.11742846607274436 0.2891133557481455 1.8323181805560884e-07 6.736999109237334 -0.7134397307511919 IETMLGDVAVAVHPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IETMLGDVAVAVHPK 15 0 P26640;A0A140T936;P26640-2 P26640 VARS Valine--tRNA ligase 0 18849700.0 5703600.0 6000100.0 7146000.0 False True 7812375.053994433 5734995.742322638 5458261.97648973 1.0 0.7340911954029088 0.698668706861295 22.89732978065198 -13.999999999999998 0.28410354634808577 3.2169216905910387 0.6884293662372967 0.9996142895950088 0.0026411067341339206 15.624617462809187 0.1689139076193775 20.17492329703399 0.013744587518911576 1.0000000000000041e-14 13.999999999999998 -2.528492324353742 IEVEKPFAIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEVEKPFAIAK 11 1 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 116011200.0 42922200.0 13240000.0 59849000.0 False True 41559658.25542447 18526801.045687888 44172751.468485855 1.0 0.4457880989257106 1.062875714641381 25.308680455238274 -6.670007792736952 1.9372226456408568 0.6462505628165567 1.0603871725532 0.2791022611426852 0.2354169094824389 0.46111867623013253 3.336218028128262 0.09782946048117705 0.26138482297356247 2.1379237274520628e-07 6.670007792736952 0.41413660973664324 IEVFVQTLLHLAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEVFVQTLLHLAAK 14 0 Q09161 Q09161 NCBP1 Nuclear cap-binding protein subunit 1 0 12710700.0 2723100.0 6100900.0 3886700.0 False True 4131141.785276414 5012146.7284507295 3118492.041398872 1.0 1.2132594301929456 0.7548741252390141 21.97810914522987 -6.78018114423743 1.534984422409233 1.1207245983992222 0.7512109840004216 0.7680817277412105 0.09019284326636502 0.25029770012686897 1.16484578607539 0.046276840080190784 0.1091856143836426 1.658894838045082e-07 6.78018114423743 -0.3695136143988006 IEVHDQK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEVHDQKER 9 1 U3KQ91;A0A0A0MSC1;O60266-2;O60266 U3KQ91 ADCY3 Adenylate cyclase type 3 1 11879200.0 1866500.0 3822500.0 6190200.0 True False 2446999.5752117103 3252197.899988302 5549697.4845912745 1.0 1.32905535944236 2.267960134039306 21.22258242029603 -6.9525717435187735 0.5298578898466816 0.9851769371711713 2.6544508286465263 0.9993879609664099 0.01329075328433822 0.08246919507417733 0.03181343829079246 0.014830924550808951 0.07764100193017925 1.1153938780179208e-07 6.9525717435187735 1.6692738914753549 up IEVIEIMTDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEVIEIMTDR 10 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;F8VYN5;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 87319000.0 22028000.0 26935000.0 38356000.0 False True 28878921.319455456 22916402.991807666 34387289.05673211 1.0 0.7935338975548613 1.1907400791166574 24.78351352014384 -6.765413378923688 1.5917723730312556 0.8808871062169399 1.192610328017373 0.712819922879905 0.08692224928173709 0.2739002983612235 1.3688221789102368 0.0430596571335197 0.10294707790003994 1.716273990950426e-07 6.765413378923688 0.3117232218004331 IEVIEIMTDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEVIEIMTDR 10 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;F8VYN5;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 89921000.0 29803000.0 16989000.0 43129000.0 False True 28856920.078337386 23772796.296464592 31832221.057734113 1.0 0.8238161325577709 1.1031052853637786 24.782413992286536 -6.736176976833367 1.7004579857738598 0.8947129614083288 1.103144427817469 0.5877956514111015 0.0740345985190202 0.3247602872321792 1.8422698054222926 0.034462817477662916 0.0849338266501462 1.8357900986931154e-07 6.736176976833367 0.20843146640914012 IEVIEIMTDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEVIEIMTDR 10 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;F8VYN5;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 139063000.0 22028000.0 68608000.0 48427000.0 False True 30172346.884316847 65576671.70368358 36989539.98537198 1.0 2.1734030818056578 1.2259417581003156 24.84672358166673 -10.094930099110854 4.180972024170381 0.9998907243727337 1.6996724186432972 0.421000971192227 0.38679946619539934 34356777.64549479 11850624.526980892 35206.52040110686 0.13241174534661793 8.036554623294769e-11 10.094930099110854 0.6997816942705635 IEVIEIMTDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEVIEIMTDR 10 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;F8VYN5;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 52189000.0 29803000.0 12377000.0 10009000.0 False True 24782514.99676247 12310322.644357847 12101835.62361279 1.0 0.49673419529721013 0.48832152931991546 24.562819267720812 IEVPLYSLLEQTHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEVPLYSLLEQTHLK 15 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 17446000.0 8745600.0 3642700.0 5057700.0 False True 8467975.715099415 5097249.106429552 3732936.64225235 1.0 0.6019442282221649 0.44082987101581755 23.013585701239837 -13.999999999865643 0.12455092994521656 2.892627146801713 0.19877027948902598 0.9996709354906366 0.004263152886346457 11.948576011163867 0.10917348008782342 5.566594180870351 0.2149323245441671 1.0000000003093673e-14 13.999999999865643 -2.6938568673126873 IEVPLYSLLEQTHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEVPLYSLLEQTHLK 15 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 18191100.0 1656700.0 3055400.0 13479000.0 False True 2269226.7606340856 2920402.325143347 10295537.808718866 1.0 1.2869592302566115 4.537024676124481 21.113769352021546 -6.924244846980057 0.792604616711626 0.938653225177491 5.115965785705084 0.9952811518817565 0.1101860909111923 0.09573828577291223 0.0931394245620754 0.09713706694150229 0.3039101032447211 1.1905705976912726e-07 6.924244846980057 4.177312560527593 up IEVPLYSLLEQTHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEVPLYSLLEQTHLK 15 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 13911100.0 8745600.0 2372900.0 2792600.0 False True 7272353.895771774 2360116.7167162304 3376519.748476476 1.0 0.32453270984081617 0.4642953020258848 22.793990976674113 -9.939200893528481 6.97757761851927 1.0000000240086557 0.39441400593806086 0.9615868405957839 0.057057839330359614 2.1327840135946068e-08 3.3035011773065526e-09 0.05524601784394305 0.01841533845808737 1.150268181196753e-10 9.939200893528481 -0.6055860180705949 IEWLESHQDADIEDFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEWLESHQDADIEDFK 16 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 102222000.0 15454000.0 47199000.0 39569000.0 False True 20260343.65674886 40157093.18026103 35474779.45264971 1.0 1.982053900990195 1.750946580850953 24.27215530960836 -10.111110840208289 5.070402737795947 0.9999730387673831 1.866500240922585 0.9493501995402011 0.09434916836752101 2.87568064482295e-05 5.041170989617728e-06 0.091356022542997 0.030451063150325003 7.742641656490003e-11 10.111110840208289 0.866527202155202 IEWLESHQDADIEDFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEWLESHQDADIEDFK 16 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 150087000.0 44000000.0 13025000.0 93062000.0 False True 42603244.08438229 18225950.42447769 68686270.39984353 1.0 0.42780663341923886 1.612230990292659 25.344459954903375 -6.775326403454278 1.5538738175375333 0.6740416652185959 1.6203066714031504 0.7505641044378848 0.24154267629988757 0.2579111287316272 1.2296020484360737 0.12247015483568253 0.29015211844628774 1.6775427505113914e-07 6.775326403454278 0.9462650061845546 IEWLESHQDADIEDFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEWLESHQDADIEDFK 16 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 213979700.0 4506900.0 202470000.0 7002800.0 False True 6837296.798524577 166337646.59466943 5618693.5105637275 1.0 24.327983923494955 0.8217711876682299 22.70499462159981 -11.675629393438136 1.5057581000671843e-12 8.385384049867728 14.44939584294999 0.0 11.364749403565039 0.0 0.7112259447500235 752839223.7695664 752839217.8453132 2.110428322378233e-12 11.675629393438136 6.064011793082262 IEWLESHQDADIEDFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEWLESHQDADIEDFK 16 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 103409000.0 15454000.0 41126000.0 46829000.0 False True 21167761.428646803 39308917.33450457 35768954.67352888 1.0 1.8570181578722318 1.6897844769320745 24.335365371131253 -10.078463054651674 4.547358410033322 0.9999538849456923 1.7734013173299776 0.9661210082302754 0.0682728644978728 10642224.66748194 11793362.87025592 4309.107564299356 0.023371617048696152 8.347125540940263e-11 10.078463054651674 0.7734474323842854 IEWLESHQDADIEDFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEWLESHQDADIEDFK 16 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 71965000.0 44000000.0 16603000.0 11362000.0 False True 36587949.53050193 16513556.34356253 13737741.668047605 1.0 0.4513386662949185 0.3754717562566602 25.12486523033765 -13.999999999999998 0.2787577661365842 5.4410835568684295 0.35235153041002787 0.9996024318123627 0.0055481067139250325 15.33148993009908 0.16723413620782895 38.78836021791268 0.030189090473717758 1.0000000000000041e-14 13.999999999999998 -5.088732026458402 IEWLESHQDADIEDFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEWLESHQDADIEDFK 16 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 25792400.0 4506900.0 13872000.0 7413500.0 False True 5834270.894280673 13100011.005531965 6064319.068933655 1.0 2.245355288245852 1.0394304924851017 22.47612094369226 -6.638645038489988 2.048918530267062 1.8152145510050532 1.0443926644839376 0.1495453193352616 0.5330289123018229 0.5368325569562691 4.30538553891417 0.2119536925635084 0.5903939740741262 2.2980261243314412e-07 6.638645038489988 -0.7708218865211156 IEYDTFGELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IEYDTFGELK 10 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 28125100.0 5208100.0 10800000.0 12117000.0 False True 6827869.535312145 9188682.098070266 10863249.074471328 1.0 1.3457612291137888 1.5910159118139477 22.70300406141033 -6.974826923237098 0.08337834971320493 0.19113592373630778 2.751805782451525 0.999999880190083 8.371877887640399e-05 0.07476513328662404 0.002423037624601046 0.02800846447346433 0.04607603978348876 1.0596759473087683e-07 6.974826923237098 2.560669858715217 IEYDTFGELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEYDTFGELK 10 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 23760600.0 8275900.0 3171700.0 12313000.0 False True 8013186.084498627 4438176.350196999 9087855.917917868 1.0 0.5538591395977407 1.134112676541753 22.933944549084142 -6.701339941045608 1.8262296025576912 0.7233228619200328 1.1324213181983338 0.4238391365311164 0.18827667912881124 0.39276165332816576 2.547598016718457 0.08222127577286469 0.21109150189858125 1.989115762669948e-07 6.701339941045608 0.409098456278301 IEYDTFGELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEYDTFGELK 10 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 25689800.0 5208100.0 9415700.0 11066000.0 False True 7133675.313610429 8999683.240443887 8452438.711423919 1.0 1.2615773559631005 1.184864510906097 22.76621412293322 -10.10378073069603 4.329374044894018 0.9999751462025669 1.2232209333884905 0.9186293232987393 0.03131788803321483 21808116.877636444 0.3979428928635894 6396.133797587387 0.010720946052522648 7.87443258607071e-11 10.10378073069603 0.22324578718592358 IEYDTFGELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IEYDTFGELK 10 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 14738100.0 8275900.0 3750200.0 2712000.0 False True 6881777.534533661 3729996.928243578 3279066.661128773 1.0 0.5420106810378518 0.47648542032548813 22.71434982451842 -13.999999999999998 0.27387984075402005 4.609733302362734 0.4555401278906043 0.9995917282823548 0.004705592045314032 15.076836619420128 0.1657035903576601 30.372746938132693 0.02669643982655896 1.0000000000000041e-14 13.999999999999998 -4.15419317447213 IEYDTFGELK(ub)VPNDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IEYDTFGELKVPNDK 15 1 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 1 8309600.0 2661200.0 3057200.0 2591200.0 True False 2576721.662667232 4277955.903087388 1912486.985666273 1.0 1.660232055742941 0.7422171410188741 21.297105275098765 -6.713700746122827 1.7820214238170142 1.404351075644289 0.7441298228195862 0.4826672094707526 0.27806261928373704 0.367679139502054 2.2782459417365812 0.1240690509753814 0.31378636488026407 1.933300013062491e-07 6.713700746122827 -0.6602212528247028 IEYDTFGELK(ub)VPNDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IEYDTFGELKVPNDK 15 1 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 1 19461900.0 5713000.0 4958800.0 8790100.0 True False 8667038.676245505 4073863.396718762 7052732.8821623055 1.0 0.4700409850349864 0.8137419418113749 23.047107711919832 -10.218184771831604 7.25511836794541 1.0000007618204942 0.6418914634231867 0.5914131553883966 0.1403153280347547 1.7290356170553496e-06 1.8612043074252573e-07 0.13586002165112132 0.045286577391352965 6.050833855230633e-11 10.218184771831604 -0.35810929839730754 IEYDTFGELK(ub)VPNDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IEYDTFGELKVPNDK 15 1 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 1 6340000.0 2466300.0 1971900.0 1901800.0 True False 3378157.7592514353 1884774.9377987066 1452634.0088004693 1.0 0.5579298162251467 0.43000774751335413 21.68780527258935 -13.999999999999998 0.17387921254389802 3.252915562661351 0.32170279855641293 0.9995068136422908 0.0054230329912138605 12.131625886755726 0.13211502345540116 9.223099798504578 0.10072167757128483 1.0000000000000041e-14 13.999999999999998 -2.931212764104938 IEYDTFGELK(ub)VPNDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IEYDTFGELKVPNDK 15 1 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 1 18924100.0 5713000.0 4311800.0 8899300.0 True False 7395591.120065998 4071844.539623184 7279718.714529073 1.0 0.5505772930814551 0.984332232048019 22.81823403401228 -10.746594223944498 10.029212878715857 1.000668416211139 0.7674547639585164 0.27705686115031225 0.17707971231335695 0.0026535540833571695 6.704671100278407e-05 0.17190861303276045 0.05715223139506932 1.7922796596048494e-11 10.746594223944498 -0.23321365225262258 IFAAEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFAAEAR 7 0 Q96L96 Q96L96 ALPK3 Alpha-protein kinase 3 0 22972200.0 6153900.0 4713300.0 12105000.0 False True 8067822.49445238 4010094.012299499 10852490.719359208 1.0 0.4970478732095224 1.3451573490643391 22.943747911927698 -6.746018536139362 1.664683457938384 0.7028704790699043 1.3463420011915 0.6317737052922301 0.21131238871021082 0.3069634889685291 1.6723709632615098 0.10033469791555996 0.24460262431978883 1.7946570273727683e-07 6.746018536139362 0.6434715221215956 IFAAEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFAAEAR 7 0 Q96L96 Q96L96 ALPK3 Alpha-protein kinase 3 0 5900500.0 1148700.0 1877900.0 2873900.0 False True 1112235.1472665896 2627755.2631191323 2121139.3748480594 1.0 2.362589664224386 1.9070961568342233 20.085030402287945 -10.223381251624952 5.074158052793454 0.9998699083366 2.1348429105300015 0.8922005302050484 0.18595444571184466 0.0002736971367208133 4.1890535137037826e-05 0.18006983183265832 0.06001653928258649 5.978865013935631e-11 10.223381251624952 1.1349730021934015 IFAAEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFAAEAR 7 0 Q96L96 Q96L96 ALPK3 Alpha-protein kinase 3 0 15129700.0 6153900.0 2463100.0 6512700.0 False True 8429163.132894386 2354272.097617522 4974534.393266811 1.0 0.2793008108278381 0.5901575654472673 23.00695797345059 -10.503743170544336 6.257056846860121 1.000443761242029 0.434729188138794 0.8151198694012651 0.12690673865252655 0.000786192350401102 6.23542265935579e-05 0.12296832857271647 0.04095897377689435 3.135139208741008e-11 10.503743170544336 -0.5657145731032349 IFAFDLDAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFAFDLDAKR 10 1 Q96P11-2;Q96P11;Q96P11-4;Q96P11-5 Q96P11-2 NSUN5 Probable 28S rRNA (cytosine-C(5))-methyltransferase 1 22259700.0 1710600.0 4735100.0 15814000.0 True False 2595105.2616113387 3890084.40949484 12688355.968477556 1.0 1.4990083319700989 4.889341544704499 21.307361627107632 -6.93326492657938 0.7194860286678226 0.9541660520744516 5.647002321036944 0.9971419533435836 0.09237406020349792 0.09097757621724431 0.06963210302089072 0.08585564555682343 0.30144880187848583 1.1660980615866233e-07 6.93326492657938 4.692836268962493 up IFANTPDSGCVLGMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFANTPDSGCVLGMR 15 0 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 0 4165460.0 384460.0 1540900.0 2240100.0 False True 526605.2516408405 1472817.9429251102 1711034.5163076755 1.0 2.796815904011556 3.2491786038523003 19.00636238336051 -9.928186514451612 0.34380214204326265 1.9195760090058698e-22 3.3524577322493214 0.9987808499364312 0.03391656803667559 1.290938534957741 0.15181816608058119 1.459305193708539 0.1362579689691901 1.1798138376165376e-10 9.928186514451612 3.3524577322493214 IFAPNHVVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFAPNHVVAK 10 0 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 18055600.0 1767700.0 9213400.0 7074500.0 False True 2317471.8184311483 7838796.633551917 6342498.60339584 1.0 3.3824776513824117 2.7368180069993264 21.144120364417986 -10.001119149525012 5.308255137910751 0.9999897322076006 3.0596478291965976 0.9313566262266827 0.2635894460609574 3.2030712263459574e-05 6.0267830699907125e-06 0.25522064976705366 0.08507312789961549 9.974263804388274e-11 10.001119149525012 2.059658096988997 IFAPNHVVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFAPNHVVAK 10 0 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 13899600.0 5130100.0 1740700.0 7028800.0 False True 4967247.783574762 2435770.5876305834 5187746.420519865 1.0 0.4903662337290613 1.0443905048735898 22.244015284534658 -6.664869429037761 1.955525091579928 0.6732752834000283 1.0421082536418187 0.25648667706531914 0.21674137307383223 0.47304092054562025 3.4823198633197836 0.08938679303759685 0.24043143448114807 2.1633688444306807e-07 6.664869429037761 0.3688329702417904 IFAPNHVVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFAPNHVVAK 10 0 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 15525900.0 1767700.0 7200900.0 6557300.0 False True 2421266.460296296 6882740.427808063 5008600.791832643 1.0 2.8426199844877074 2.068587193505224 21.207330425940878 -10.58371670176099 6.109360640592762 0.9958330497044203 2.455603588996466 0.8250300345910277 0.31599756368157167 0.01792440265342717 0.0012213424424752863 0.3057837711553567 0.10198777513173708 2.607854146262156e-11 10.58371670176099 1.4597705392920455 IFAPNHVVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFAPNHVVAK 10 0 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 7426510.0 5130100.0 1364000.0 932410.0 False True 4265905.45196427 1356651.861267197 1127372.6200232597 1.0 0.3180220181960469 0.2642751070594291 22.024420559968934 -13.999999999999998 0.36020523866935167 9.934575071020904 0.2578225124830258 0.9997736614186535 0.005038047503414904 21.71901238733738 0.19398173178211697 149.18634305019773 0.015499048635350003 1.0000000000000041e-14 13.999999999999998 -9.676752558537878 IFAPNHVVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFAPNHVVAK 10 0 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 4165800.0 1932400.0 0.0 2233400.0 False True 2501529.8932987084 0.0 1826944.1166191995 1.0 0.0 0.7303307154207346 21.254379261973046 -10.666341130573658 9.082744252341294 1.00059172843329 0.36516535930909966 0.501854055902338 0.29815626604376494 0.003575391365847642 0.00013134309490638106 0.28891335792307504 0.09622952107957415 2.1560502048546884e-11 10.666341130573658 -0.6354263691241903 IFAPNHVVAK(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFAPNHVVAKSR 12 1 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 1 14791100.0 1156300.0 1113800.0 12521000.0 True False 1515920.4976251281 947625.3815583946 11225447.029912988 1.0 0.6251154879447596 7.4050367730359214 20.53176266274771 -6.893817407244296 0.9995109247133014 0.6683404156315599 8.033761182722305 0.9832318117589626 0.40291327065284516 0.11610106244217526 0.20418502629806992 0.30550104647175874 0.7728795342911342 1.276975581649323e-07 6.893817407244296 7.365420767090745 up IFAPNHVVAK(ub)SR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFAPNHVVAKSR 12 1 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 1 40683300.0 3196300.0 15814000.0 21673000.0 True False 4849020.7808302995 12991868.144654034 17389322.050386626 1.0 2.679276648187396 3.586151273909172 22.209262005845915 -8.853329171141088 0.23894685898953488 2.0307025544235407e-21 4.294671489244546 0.9993006327171366 0.0283330635538717 0.3649841174449594 0.07585422174888751 0.6939446776169069 0.39228726925630647 1.4017508523847647e-09 8.853329171141088 4.294671489244546 IFAPNHVVAK(ub)SR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFAPNHVVAKSR 12 1 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 1 38273700.0 1156300.0 1042400.0 36075000.0 True False 1583815.3578325561 996343.3212441657 27554827.98794667 1.0 0.6290779517428451 17.39775274414268 20.5949727242706 -6.901841321867522 0.9495382306730321 0.33760655238816967 19.225337073940395 0.9874607955351562 0.8755458574331658 0.1100630123931624 0.16986762278646717 0.6890824388540112 1.81005094506411 1.2535991186645647e-07 6.901841321867522 18.887730521552225 up IFAPNHVVAK(ub)SR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFAPNHVVAKSR 12 1 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 1 55690300.0 3196300.0 12964000.0 39530000.0 True False 4137673.358492376 12242542.00372811 32335945.612052005 1.0 2.9587985669774732 7.815006843322717 21.980388327938364 -6.955640958288164 0.4930479173146477 0.8966027950240579 10.084193918044209 0.9995728037767917 0.05921186841948397 0.0812966705663722 0.027177263211264714 0.07038307594601326 0.4005315120542447 1.1075390348000744e-07 6.955640958288164 9.18759112302015 IFASIAPSIYGHEDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFASIAPSIYGHEDIK 16 0 P49736 P49736 MCM2 DNA replication licensing factor MCM2 0 10386400.0 2252100.0 2631500.0 5502800.0 False True 3084762.230714089 2515231.6287931902 4203151.973723439 1.0 0.81537293336574 1.3625529811905324 21.55672786200862 -6.815676785726331 1.390377207700052 0.90003090094998 1.3734357806894324 0.8741731819366612 0.08062371208827987 0.19915799704916357 0.7576252986681647 0.04557965942651448 0.10519888701283857 1.5287033393791594e-07 6.815676785726331 0.47340487973945244 IFASIAPSIYGHEDIK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFASIAPSIYGHEDIKR 17 1 P49736 P49736 MCM2 DNA replication licensing factor MCM2 1 31181900.0 2580600.0 3518300.0 25083000.0 True False 3340637.5712309293 3322503.5121657387 20518151.37331395 1.0 0.9945716772087585 6.141986652492086 21.671692041206775 -6.9066561390834424 0.9181867420587747 0.8232858909701748 6.761773987322001 0.98959778513846 0.24735287245700052 0.10667150661322719 0.1510617682503582 0.1992208440780029 0.5380080782699553 1.239777815692486e-07 6.9066561390834424 5.938488096351826 up IFASIAPSIYGHEDIKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFASIAPSIYGHEDIKR 17 1 P49736 P49736 MCM2 DNA replication licensing factor MCM2 0 85196000.0 24268000.0 37637000.0 23291000.0 False True 33240535.418040704 35974072.89108466 17790145.493202083 1.0 1.0822350614593403 0.5351943122897714 24.986440284548767 -6.868619645724654 1.1414321955869355 1.0461388360160324 0.5039943488320142 0.9632829138999867 0.04615016618457631 0.13818207686275397 0.33735052217390066 0.031404921379543545 0.07417624705737066 1.3532572244414885e-07 6.868619645724654 -0.5421444871840182 IFASNLK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFASNLKER 9 1 Q13895;H7BY94 Q13895 BYSL Bystin 1 4581000.0 1504800.0 1241600.0 1834600.0 True False 1972807.3725039307 1056358.119718895 1644773.1907258485 1.0 0.5354593329495428 0.833722143200563 20.911818665628793 -10.097698373737039 5.162774707969576 1.0000069261904163 0.6845907380745073 0.5985613068601857 0.12176528239583141 9.707634264092187e-06 1.6965780689944572e-06 0.11790131561983201 0.039299575905167666 7.985491031515155e-11 10.097698373737039 -0.315416188115909 IFASNLK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFASNLKER 9 1 Q13895;H7BY94 Q13895 BYSL Bystin 1 21714200.0 2636800.0 4061400.0 15016000.0 True False 4000218.375901306 3336611.438136961 12048081.018253395 1.0 0.8341073222996669 3.011855825380731 21.93164732963174 -6.888526682834585 1.0311001673071576 0.8788199240474722 3.1938154205100266 0.9799368852758217 0.14020222711729796 0.12034499804937525 0.22891614531255966 0.10380291814267244 0.25743724560259196 1.2926272799969105e-07 6.888526682834585 2.3149954964625543 up IFASNLK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFASNLKER 9 1 Q13895;H7BY94 Q13895 BYSL Bystin 1 5021100.0 1504800.0 1283900.0 2232400.0 True False 2061165.225690939 1227173.0527104617 1705153.0977211974 1.0 0.5953783022411955 0.8272762787124938 20.975028727151685 -10.18568559109322 5.451839165866555 1.0000104928760043 0.711327290476804 0.6738552752128237 0.09467195245657964 1.2074660323891408e-05 1.8035469553653655e-06 0.09166905376400283 0.0305552412680854 6.521003133653896e-11 10.18568559109322 -0.2886832023992003 IFASNLK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFASNLKER 9 1 Q13895;H7BY94 Q13895 BYSL Bystin 1 5631300.0 1205000.0 2653200.0 1773100.0 True False 1002010.8905512458 2638906.6849810323 2143847.012111884 1.0 2.633610781943962 2.13954462204744 19.93446675815559 -10.181028494569906 6.39756071941676 0.9999920109113131 2.3865777019957024 0.9130558436328853 0.20170166515380702 2.2985546644986236e-05 2.9422245802978365e-06 0.19529791808550134 0.06509893250358234 6.591306474913535e-11 10.181028494569906 1.3865856910843894 IFASNLK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFASNLKER 9 1 Q13895;H7BY94 Q13895 BYSL Bystin 1 21814900.0 2636800.0 2277100.0 16901000.0 True False 3413389.5790985534 2150377.3832682273 13825191.418904409 1.0 0.6299829929861459 4.050282306936532 21.70277365172419 -6.880105214706143 1.079157528844502 0.7703211989240211 4.293219455073509 0.9737725548543847 0.24820180645364423 0.12753944288126598 0.271693204781731 0.17714745018848693 0.4285221484447403 1.3179374086975898e-07 6.880105214706143 3.522898256149488 up IFATLTRPLALFYENSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFATLTRPLALFYENSK 17 1 Q5UIP0-2;Q5UIP0 Q5UIP0-2 RIF1 Telomere-associated protein RIF1 0 3604000.0 0.0 1355400.0 2248600.0 False True 0.0 1896618.2883176226 1659624.2034459636 0.0 IFATLTRPLALFYENSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFATLTRPLALFYENSK 17 1 Q5UIP0-2;Q5UIP0 Q5UIP0-2 RIF1 Telomere-associated protein RIF1 0 5973700.0 0.0 2224400.0 3749300.0 False True 0.0 2212416.7156911683 4533261.295195466 0.0 IFCFILSTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFCFILSTR 9 0 A0A0A0MS59;A0A0C4DFX4;Q6ZRS2-3;Q6ZRS2-2;Q6ZRS2 A0A0A0MS59 SRCAP Helicase SRCAP 0 11765200.0 4923500.0 0.0 6841700.0 False True 7469309.456064203 0.0 5489434.996176357 1.0 0.0 0.7349320614530946 22.832543440134927 -10.68774795396556 9.177346081265073 1.000861864041361 0.36746603221751745 0.49689848978934326 0.30003475769530863 0.005296350360815972 0.00018020378603709583 0.29080669601948866 0.09683580165310891 2.052352931557757e-11 10.68774795396556 -0.6333958318238435 IFCFILSTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFCFILSTR 9 0 A0A0A0MS59;A0A0C4DFX4;Q6ZRS2-3;Q6ZRS2-2;Q6ZRS2 A0A0A0MS59 SRCAP Helicase SRCAP 0 13999200.0 4923500.0 3777600.0 5298100.0 False True 6373567.806694378 3567373.2392227226 4333900.163096707 1.0 0.5597137031280639 0.6799802394107524 22.603669762227376 -10.293668285365511 8.343596341238195 1.000000485972557 0.6198469712694136 0.9301768417404613 0.04909860783741772 4.4388001133434605e-07 3.752710191181539e-08 0.04753958353684185 0.01584650753969065 5.08547723604488e-11 10.293668285365511 -0.3801535147031435 IFCVHGGLSPSIQTLDQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFCVHGGLSPSIQTLDQIR 19 0 H3BTA2;P60510;H3BV22 H3BTA2 PPP4C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 4 catalytic subunit 0 29033500.0 8763400.0 10594000.0 9676100.0 False True 13294718.490357064 8703417.928700205 7763614.593814702 1.0 0.6546522918114419 0.5839623155199423 23.664349893316434 -13.999999999999998 0.22297706764577466 3.111592577779826 0.5472121017510234 0.99950104925641 0.004060137352884178 13.082312599397381 0.14956757289337116 12.182979833290815 0.03836752720505656 1.0000000000000041e-14 13.999999999999998 -2.564380476028803 IFCVHGGLSPSIQTLDQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFCVHGGLSPSIQTLDQIR 19 0 H3BTA2;P60510;H3BV22 H3BTA2 PPP4C Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 4 catalytic subunit 0 20637900.0 8763400.0 5921100.0 5953400.0 False True 11344394.05243942 5591585.579934785 4869942.287042509 1.0 0.4928941602422925 0.4292818342285378 23.435476215408883 -13.999999999999998 0.2927340287224655 5.4377499024368525 0.4124198632627524 0.9996335826803355 0.004888286651929768 16.130353561036916 0.17163903892435078 43.17650886118073 0.023731936346948618 1.0000000000000041e-14 13.999999999999998 -5.0253300391741 IFDAVGFTFPNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFDAVGFTFPNR 12 0 C9J5H8;Q9UBB6-2;Q9UBB6;Q9UBB6-3 C9J5H8 NCDN Neurochondrin 0 1882910.0 733400.0 597180.0 552330.0 False True 961494.5022557038 508083.0717894079 495180.1899234749 1.0 0.5284305532662175 0.5150109426125296 19.874919082817264 IFDAVGFTFPNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFDAVGFTFPNR 12 0 C9J5H8;Q9UBB6-2;Q9UBB6;Q9UBB6-3 C9J5H8 NCDN Neurochondrin 0 2281090.0 733400.0 686120.0 861570.0 False True 1004557.7993897761 655804.9497045743 658084.9105911348 1.0 0.6528294838813122 0.6550991003114922 19.938129144340156 -10.02975165738068 7.010602565193165 1.0000000545877754 0.6539642920964046 0.9999677353310914 0.000926567027630487 7.917334612356878e-10 1.0869316659733024e-10 0.000897144813841867 0.00029904822226303073 9.337881162274309e-11 10.02975165738068 -0.3460357624913708 IFDIDEAEEGVK(ub)DLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFDIDEAEEGVKDLK 15 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 22500700.0 8064900.0 10975000.0 3460800.0 True False 10573162.000602692 9337572.780214936 3102709.6143377405 1.0 0.8831391006477225 0.29345143999126083 23.333903556579855 -6.939600978760225 0.6632665531923647 1.0066666241685025 0.13628151167883198 0.9981111498384965 0.013439337052943985 0.08794918197837952 0.05544245864280305 0.01304295350640349 0.05084313562211136 1.1492090072524558e-07 6.939600978760225 -0.8703851124896705 down IFDIDEAEEGVK(ub)DLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFDIDEAEEGVKDLK 15 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 50467100.0 23266000.0 19931000.0 7270100.0 True False 22527433.565164525 27889552.238791928 5365842.711675035 1.0 1.2380261674334336 0.23819147867658338 24.42517962830818 -6.843903984540954 1.2642092759646155 1.1266313118207794 0.20269643238192597 0.9309466251103576 0.11206057144610654 0.1642917871922369 0.5083698242247162 0.06945834840204555 0.16022005429817412 1.43250456776991e-07 6.843903984540954 -0.9239348794388533 down IFDIDEAEEGVK(ub)DLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFDIDEAEEGVKDLK 15 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 21143400.0 8064900.0 8905400.0 4173100.0 True False 11046711.47572756 8511929.981780311 3187499.727692317 1.0 0.7705397212992473 0.2885473866766654 23.397113618102747 -6.959074177313095 0.4482911020633106 1.0158176130442242 0.024216242034206317 0.9997343054238028 0.004832753610014577 0.08003350708092391 0.02236591353041143 0.006426169124430522 0.039879063667874665 1.0988181457312742e-07 6.959074177313095 -0.9916013710100179 down IFDIDEAEEGVK(ub)DLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFDIDEAEEGVKDLK 15 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 46179600.0 23266000.0 19919000.0 2994600.0 True False 19346709.85856042 19811692.393388074 3620757.0145340036 1.0 1.02403419176837 0.1871510474393098 24.205584903742455 -6.900286640115764 0.9594360987055904 1.0345214310607593 0.09878735178881366 0.9867088845676909 0.044843149017152514 0.1111952201400716 0.17622459748398617 0.03503499333267287 0.0912886625331267 1.2580947784766912e-07 6.900286640115764 -0.9357340792719456 down IFDSEEILAGYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFDSEEILAGYK 12 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 12386800.0 2195100.0 4942100.0 5249600.0 False True 2877797.3573786374 4204757.9441549145 4706421.749718972 1.0 1.4611028581890821 1.6354250022684063 21.456533576344093 -11.538883972066246 0.1729376196090555 6.963172754287656e-17 1.808231253468619 0.9994995457235966 0.005997017839148568 4.250252986881064 0.10692047814995553 1.7278364160682358 0.13556561833821196 2.891452271689414e-12 11.538883972066246 1.808231253468619 IFDSEEILAGYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFDSEEILAGYK 12 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 10136400.0 3327900.0 1357000.0 5451500.0 False True 3222257.63610036 1898857.1766615126 4023588.608505583 1.0 0.5892940264576568 1.248686189281565 21.61964041888221 -6.738319083384841 1.6933676562666093 0.7551501319614691 1.2488936538441349 0.5971605074826183 0.17256820683194304 0.32086100387535627 1.805994604798136 0.08065009639329244 0.19823489757680904 1.8267575737758074e-07 6.738319083384841 0.4937435218826658 IFDSEEILAGYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFDSEEILAGYK 12 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 11778700.0 2195100.0 5777500.0 3806100.0 False True 3006687.790347006 5522230.9463623995 2907177.5690900576 1.0 1.8366492736929865 0.966903706604847 21.519743637866984 -6.654983776107867 1.9905906684574532 1.5407475669124369 0.970545533589601 0.21453707487906493 0.3566572408639389 0.4964561719153248 3.7760742669397995 0.14502269044710364 0.39521415652572117 2.2131773854903246e-07 6.654983776107867 -0.5702020333228358 IFDSEEILAGYK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFDSEEILAGYKR 13 1 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 1 5317700.0 3232500.0 0.0 2085200.0 True False 4237838.8035745295 0.0 1869443.5066507887 1.0 0.0 0.441131339180233 22.014897281690576 -10.470796229736873 5.771941920701804 1.000687457895655 0.22056566959011994 0.8062981779498762 0.18009111509036638 0.0015944411370505558 0.0001461870604894052 0.17451158488233434 0.05812415746207576 3.382234928939946e-11 10.470796229736873 -0.7801217883055351 IFDSEEILAGYK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFDSEEILAGYKR 13 1 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 1 17350300.0 5362600.0 5319400.0 6668300.0 True False 5192367.19833883 7443464.160304537 4921672.185288051 1.0 1.4335396315356683 0.9478667431037271 22.307960982031442 -6.671365888526758 1.9332212574781098 1.2764105146814821 0.9498467603553633 0.28486718240710907 0.1841019625274646 0.457955322572338 3.3011825916990323 0.07664309864680255 0.20435571748915835 2.1312486020665708e-07 6.671365888526758 -0.32656375432611884 IFDSEEILAGYK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFDSEEILAGYKR 13 1 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 1 11294300.0 3232500.0 3288700.0 4773100.0 True False 4427642.605027881 3143394.35972342 3645792.085080204 1.0 0.7099476267921642 0.8234160726839528 22.078107343213468 -10.106073284395379 4.806385915035438 1.0000117866869682 0.7666818497359724 0.8493405748736884 0.04632329906409682 5.8510422288274875e-06 1.0882152514937647e-06 0.044854606468743854 0.01495078048369836 7.832974552153553e-11 10.106073284395379 -0.2333299369509958 IFDSEEILAGYK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFDSEEILAGYKR 13 1 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 1 16167600.0 5362600.0 5878800.0 4926200.0 True False 4459239.503460675 5847129.737549566 5956245.643824687 1.0 1.311239222071789 1.3357088443449232 22.08836625746572 -12.200845667333523 0.39284405166195263 5.599256240682981e-16 1.3375531059809604 0.9997433391725765 0.002448170763692782 6.450400855934665 0.20184066856252572 5.296461729554894 0.006385813214717632 6.297299265064209e-13 12.200845667333523 1.3375531059809598 IFDSEEILAGYK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFDSEEILAGYKR 13 1 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 1 58224700.0 7698700.0 17553000.0 32973000.0 True False 9966118.914064778 16576160.119672906 26972252.331550505 1.0 1.663251287949178 2.706394792609354 23.24860035744436 -6.964458180501633 0.36723676888660506 0.9172259696356613 3.4885730532889405 0.9999015315844563 0.006969641331429375 0.07814535148186892 0.015511474010257632 0.013809928560482939 0.08872706804148192 1.0852800494227767e-07 6.964458180501633 2.5713470836532792 IFDYSPLDPTQDFNTQMTK(ub)LGHGLLSGQYSKPPVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFDYSPLDPTQDFNTQMTKLGHGLLSGQYSKPPVK 35 2 Q92995;Q92995-2;H7C5J3 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 48336300.0 6197300.0 10792000.0 31347000.0 True False 9401757.183318103 8866083.281719146 25151251.710121807 1.0 0.9430240654853943 2.6751649951935192 23.164498990235906 -6.8992948325739745 0.965728284698385 0.9265838727373512 2.854392484382722 0.9862118204843016 0.09434315945591976 0.11192575407058034 0.1803675147664307 0.07336608805332687 0.19021688361150046 1.2609711994922337e-07 6.8992948325739745 1.927808611645371 up IFEAFK(ub)LTDDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFEAFKLTDDVK 12 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 10972200.0 3982900.0 4492200.0 2497100.0 True False 3856465.0196292326 6285958.886513531 1843034.59860576 1.0 1.6299794901595852 0.4779077702571648 21.878847594196852 -6.75825719425677 1.6192880203529523 1.3667289526695938 0.4740968581245017 0.6836904137235403 0.2649072894302152 0.28586679104065366 1.4769674245875677 0.12910923056187928 0.31077428481930697 1.74478856276467e-07 6.75825719425677 -0.8926320945450921 IFEELTLHK(ub)PTQVMPCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFEELTLHKPTQVMPCR 17 1 Q14145 Q14145 KEAP1 Kelch-like ECH-associated protein 1 1 169817400.0 13369000.0 41823400.0 114625000.0 True False 20281750.40481818 34359687.50228432 91969318.50807783 1.0 1.6941184471988053 4.534584869273876 24.273678832892795 -6.944351280211826 0.6177567080649036 0.9688582547792993 5.409750068321276 0.9986800862328663 0.05555317174704288 0.0858364139656833 0.04598264852299925 0.056061352921865516 0.24018796557648023 1.1367074851008481e-07 6.944351280211826 4.440891813541977 IFEELTLHK(ub)PTQVMPCR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IFEELTLHKPTQVMPCR 17 1 Q14145 Q14145 KEAP1 Kelch-like ECH-associated protein 1 1 140925300.0 18135700.0 46763600.0 76026000.0 True False 23477021.158092264 44161164.55149183 62190048.09263508 1.0 1.8810378137036339 2.64897525430729 24.484746030364754 -6.972734930560839 0.18132061539278493 0.41663325657937583 4.134173737033038 0.9999966053716792 0.0012412811954152026 0.07542477679524076 0.005726771453556375 0.029229525026660246 0.0858361858550704 1.0647927107782083e-07 6.972734930560839 3.717540480453662 IFEIFGPVAHPFYVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFEIFGPVAHPFYVLR 16 0 Q96HR8;Q96HR8-2 Q96HR8 NAF1 H/ACA ribonucleoprotein complex non-core subunit NAF1 0 93512000.0 25693000.0 34739000.0 33080000.0 False True 24877389.778637186 48610463.861491814 24415355.62127206 1.0 1.9540017780818304 0.9814275468014781 24.568331785091356 -6.650589543416881 2.006518604027614 1.6187657283643275 0.9855220086236721 0.19642985123563284 0.40711989364104695 0.5070732799738873 3.913877370195987 0.16451779912535328 0.45092689049757195 2.2356841948428073e-07 6.650589543416881 -0.6332437197406554 IFEIFGPVAHPFYVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFEIFGPVAHPFYVLR 16 0 Q96HR8;Q96HR8-2 Q96HR8 NAF1 H/ACA ribonucleoprotein complex non-core subunit NAF1 0 42989000.0 15382000.0 11889000.0 15718000.0 False True 23335618.574830797 9767315.060819024 12611330.410555866 1.0 0.41855822375130014 0.5404326596320924 24.476030374625346 -10.290646893059412 6.276792163403843 1.0000183637983147 0.4794954416920969 0.9605054416635966 0.04975503009958202 1.2786569830394371e-05 1.4450287435693217e-06 0.048176797240705345 0.016058366913810698 5.1209803212126196e-11 10.290646893059412 -0.5205229221062178 IFEIFGPVAHPFYVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFEIFGPVAHPFYVLR 16 0 Q96HR8;Q96HR8-2 Q96HR8 NAF1 H/ACA ribonucleoprotein complex non-core subunit NAF1 0 88665000.0 25693000.0 29151000.0 33821000.0 False True 21364867.89289063 28993957.77697956 40892814.729364365 1.0 1.3570857504168132 1.9140214175146786 24.348737060525632 -6.964601060325203 0.36483843270884037 0.9545849481187165 2.3357520425739016 0.9999046786915979 0.003672047924777658 0.07809665003681857 0.015339161996679108 0.0074036102457023835 0.04743527093359057 1.0849230586626841e-07 6.964601060325203 1.381167094455185 IFEIFGPVAHPFYVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFEIFGPVAHPFYVLR 16 0 Q96HR8;Q96HR8-2 Q96HR8 NAF1 H/ACA ribonucleoprotein complex non-core subunit NAF1 0 36407000.0 15382000.0 10303000.0 10722000.0 False True 19912302.22455018 9729628.992935114 8770706.017010422 1.0 0.4886240115891424 0.4404666983306875 24.247156696717795 -13.999999999999998 0.3342056078843193 6.709903564408075 0.4323523291080513 0.9997235034006648 0.004209924166697297 19.1848200565187 0.18509758702105986 77.16455509055041 0.015193992308061533 1.0000000000000041e-14 13.999999999999998 -6.277551235300024 IFFIDPNERPVTLYHLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFFIDPNERPVTLYHLLK 18 1 O95619;F8VTR4;F8W1B9 O95619 YEATS4 YEATS domain-containing protein 4 0 16326500.0 9309800.0 2822200.0 4194500.0 False True 9014265.494926874 3949119.177578573 3095834.6176972757 1.0 0.43809661250837273 0.3434372572495869 23.10377851134258 -13.999999999999998 0.25059289761297093 4.91948280561098 0.3055903041342124 0.999543805986817 0.006189396423196995 14.021540394215739 0.15840349193615277 27.673935075516134 0.04354113723676584 1.0000000000000041e-14 13.999999999999998 -4.6138925014767675 IFFIDPNERPVTLYHLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFFIDPNERPVTLYHLLK 18 1 O95619;F8VTR4;F8W1B9 O95619 YEATS4 YEATS domain-containing protein 4 0 13514500.0 9309800.0 2594200.0 1610500.0 False True 7741511.194069706 2580224.529691614 1947248.103889339 1.0 0.3332972678084048 0.2515333318100742 22.884183786776855 -13.999999999999998 0.29598413556765985 6.943211127026922 0.2305659407437653 0.9996408577655859 0.006352856356160663 16.3315057007505 0.17266997126006642 59.30602034565299 0.030068724807180702 1.0000000000000041e-14 13.999999999999998 -6.712645186283157 IFGGLDMLAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFGGLDMLAEK 11 0 Q92688-2;Q92688 Q92688-2 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B 0 25699700.0 5200100.0 9024600.0 11475000.0 False True 6817381.457840034 7678164.85761528 10287677.075972494 1.0 1.1262630535049993 1.5090364445048907 22.70078627877741 -6.951215093883497 0.5453398889904268 0.994554162853998 1.6585843704492678 0.999293226535477 0.00575382365981155 0.08300144223625706 0.03397111710896108 0.006283141624798523 0.03172738574164645 1.1188835945348277e-07 6.951215093883497 0.6640302075952698 IFGGLDMLAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFGGLDMLAEK 11 0 Q92688-2;Q92688 Q92688-2 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B 0 21977100.0 5200100.0 8533800.0 8243200.0 False True 7122717.497418556 8156748.49849718 6296325.934033039 1.0 1.1451736646095232 0.8839780513989188 22.763996340300302 -6.755843099999929 1.6278273821154503 1.084763127900686 0.8832074148731046 0.6737786905950811 0.061030395063606295 0.2900124093997924 1.513537554285628 0.029593512215763933 0.07142104473815349 1.754514250546672e-07 6.755843099999929 -0.20155571302758135 IFGGLDMLAEKLPNLTHLNLSGNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFGGLDMLAEKLPNLTHLNLSGNK 24 1 Q92688-2;Q92688 Q92688-2 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B 0 20553800.0 6558200.0 4250100.0 9745500.0 False True 8489719.181448782 4013578.198861836 7971918.997274297 1.0 0.47275747443237737 0.9390085616370033 23.01728540316944 -10.322938792091003 8.375532253610617 1.0000006277288898 0.7058830180346909 0.34664682609362885 0.19034620927820606 2.2312854037132575e-06 1.8034416993000527e-07 0.18430231733321298 0.06143397487901698 4.7540222270832436e-11 10.322938792091003 -0.29411760969419887 IFGLLMGTLQK ddPTM_RPMI8226_Bortezomib_1h_R1 2 IFGLLMGTLQK 11 0 Q9H307 Q9H307 PNN Pinin 0 37210700.0 10898700.0 15477400.0 10834600.0 False True 14288301.243160918 13168232.250432676 9713539.524821902 1.0 0.9216093660354227 0.6798246593149958 23.768331066736902 -6.950825413087567 0.5497054208290317 1.0033496607945223 0.586731373624809 0.9992644868485876 0.00369559177910068 0.0831559499026241 0.034603439782431314 0.004012627092422604 0.020056982937728784 1.1198879893297507e-07 6.950825413087567 -0.4166182871697133 IFGLLMGTLQK ddPTM_RPMI8226_Bortezomib_2h_R1 2 IFGLLMGTLQK 11 0 Q9H307 Q9H307 PNN Pinin 0 61389000.0 36033100.0 13609800.0 11746100.0 False True 34889248.9640217 19044264.114169408 8669444.034553325 1.0 0.5458490704058471 0.24848468488081765 25.05627920621091 -8.333682615042749 0.24501250056384438 1.2213883575065345 2.7939755663534338e-24 0.9994718384639116 0.00710187924506783 0.10615365902765755 0.05784493340266763 0.1099576839664261 0.10800959281461213 4.637857332546454e-09 8.333682615042749 -1.2213883575065345 down IFGLLMGTLQK ddPTM_RPMI8226_Bortezomib_8h_R1 2 IFGLLMGTLQK 11 0 Q9H307 Q9H307 PNN Pinin 0 42193100.0 14015100.0 11472500.0 16705500.0 False True 21261931.341055203 9425142.739948375 13403650.60271923 1.0 0.44328723429508626 0.6304060711943783 24.341769315154377 -10.23167717611537 4.780292892944178 1.0000983817391722 0.5368466527435644 0.8909333695826779 0.07639094528178374 8.011369228584392e-05 1.2876391177762012e-05 0.07398083799523834 0.024655071572539107 5.865740202540652e-11 10.23167717611537 -0.46325172899560785 IFGLLMGTLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 IFGLLMGTLQK 11 0 Q9H307 Q9H307 PNN Pinin 0 77584600.0 10898700.0 31268100.0 35417800.0 False True 14928243.916293059 29886571.952220555 27052845.092487786 1.0 2.002015248397811 1.8121920598417898 23.831541128259794 -10.218517590655656 4.701132674425519 0.9998077774088007 1.907103654123818 0.9682011399664182 0.0774949922321713 0.00015616085328551665 2.5959105119504762e-05 0.07504977031932361 0.0250114011921887 6.046198613371192e-11 10.218517590655656 0.9072958767150173 IFGLLMGTLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IFGLLMGTLQK 11 0 Q9H307 Q9H307 PNN Pinin 0 58540700.0 36033100.0 12522700.0 9984900.0 False True 29963119.18698928 12455237.729538683 12072696.425038606 1.0 0.41568561843678314 0.4029185462867586 24.836684481645186 IFGLLMGTLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IFGLLMGTLQK 11 0 Q9H307 Q9H307 PNN Pinin 0 56499500.0 14015100.0 25212400.0 17272000.0 False True 18142823.228922978 23809307.776519172 14128673.225685855 1.0 1.3123265037694234 0.7787472240352409 24.112895637246826 -6.748056834676029 1.6569244576073614 1.184083588171027 0.7778369330789965 0.6405527728107063 0.13123191267021458 0.3034775906000329 1.6386238778458049 0.06258077794220365 0.15224712368997165 1.7862537984553221e-07 6.748056834676029 -0.4062466550920305 IFGPIWNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFGPIWNR 8 0 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 13225600.0 2646200.0 3309100.0 7270300.0 False True 3469193.8258372513 2815395.1787707754 6518039.097642073 1.0 0.8115416203622786 1.8788339380458274 21.72616901639484 -6.86128665150053 1.1791075063813061 0.8973689396759139 1.9318290773970552 0.9551921267023998 0.09845470903302136 0.1454883279425618 0.3836090322236501 0.06508702922475139 0.15217058405066705 1.376300756209369e-07 6.86128665150053 1.0344601377211413 IFGPIWNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFGPIWNR 8 0 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 6923600.0 2664000.0 1456400.0 2803200.0 False True 2579432.7781998767 2037948.1150256684 2068957.825802596 1.0 0.7900760710840865 0.8020979818851769 21.298622418675254 -10.26365379698888 8.05896798756572 1.0000002372763157 0.796087026485719 0.997399909430705 0.0049079245326541995 2.092546194978885e-08 1.9067113063485545e-09 0.004752083018060561 0.0015840258316177117 5.44936882660399e-11 10.26365379698888 -0.20391321079059666 IFGPIWNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFGPIWNR 8 0 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 9781000.0 2646200.0 3027500.0 4107300.0 False True 3624571.6508661327 2893735.03939631 3137240.332498777 1.0 0.7983660741552231 0.8655478866720976 21.789379077917733 -10.360605279673386 7.919532686600542 1.0000014511526176 0.8319569804136604 0.8929578724122326 0.027426860110277767 7.027460754961756e-07 5.6763362010497954e-08 0.02655617221313577 0.008851981037155524 4.359078804052106e-11 10.360605279673386 -0.16804447073895723 IFGPIWNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFGPIWNR 8 0 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 6420900.0 2664000.0 2544400.0 1212500.0 False True 2215234.0352103924 2530692.812176145 1466028.1440334206 1.0 1.1424042660737614 0.6617937972834478 21.07902769410953 -6.8273232376602735 1.339745319083251 1.076245708546395 0.6495468947564429 0.9004239966199353 0.06360455014013996 0.18414240328471831 0.6473340916358115 0.0372845164228611 0.08582098007443921 1.488252985162477e-07 6.8273232376602735 -0.4266988137899521 IFGQANTTLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFGQANTTLKR 11 1 B7Z3Z9;E7EPM6;P33121-2;P33121-3;P33121 B7Z3Z9 ACSL1 Long-chain-fatty-acid--CoA ligase 1 1 9381000.0 2024000.0 2463100.0 4893900.0 True False 3070555.9742203583 2023540.560711861 3926618.5199274346 1.0 0.6590143862222397 1.2787972448293956 21.550068472030194 -6.757328275175411 1.622375148299167 0.8012796157784426 1.2807784511921547 0.6800093433335248 0.14337060024365136 0.2874378191733314 1.4904585366772671 0.06974399881754552 0.16806111650914543 1.74852451160816e-07 6.757328275175411 0.4794988354137121 IFGQANTTLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFGQANTTLKR 11 1 B7Z3Z9;E7EPM6;P33121-2;P33121-3;P33121 B7Z3Z9 ACSL1 Long-chain-fatty-acid--CoA ligase 1 1 7546700.0 2024000.0 2894400.0 2628300.0 True False 2620107.8990046536 2733324.0956179197 2149976.3686353737 1.0 1.0432105092527966 0.8205678741139336 21.321194794122643 -6.856367651502954 1.2038942238279073 1.0232545692507031 0.810507945644552 0.9490759712678026 0.021753461411665113 0.15059207463318544 0.4168163151352976 0.014112096115876098 0.03281984026559623 1.391977926686456e-07 6.856367651502954 -0.21274662360615115 IFGSNK(ub)WTTEQQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFGSNKWTTEQQQR 14 1 H3BN98;H3BPJ2;Q15041-2;Q15041;Q15041-3 H3BN98 ARL6IP1 ADP-ribosylation factor-like protein 6-interacting protein 1 1 72385000.0 17430000.0 12281000.0 42674000.0 True False 22850898.792360097 10448722.670963066 38258503.83791283 1.0 0.45725652920297655 1.674266915518617 24.445747576006006 -6.7854372314265605 1.5142613341189552 0.6948600842442408 1.685682632372772 0.7863112712137594 0.23011938440974009 0.24220376757090636 1.0971330810846056 0.11964494851845912 0.281107392504326 1.638938919979431e-07 6.7854372314265605 0.9908225481285312 IFGSNK(ub)WTTEQQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFGSNKWTTEQQQR 14 1 H3BN98;H3BPJ2;Q15041-2;Q15041;Q15041-3 H3BN98 ARL6IP1 ADP-ribosylation factor-like protein 6-interacting protein 1 1 95959000.0 11874000.0 15260000.0 68825000.0 True False 11497066.369498985 21353397.579848737 50797667.7942579 1.0 1.8572909726343754 4.418315608668748 23.45476244937266 -6.951545613593075 0.541609211059154 0.9626890737611269 5.431512374772746 0.9993170643282453 0.037949110591374645 0.08287096556822961 0.03343920994745176 0.04164807536965209 0.21214431455226626 1.1180323923926487e-07 6.951545613593075 4.468823301011619 IFGSNK(ub)WTTEQQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFGSNKWTTEQQQR 14 1 H3BN98;H3BPJ2;Q15041-2;Q15041;Q15041-3 H3BN98 ARL6IP1 ADP-ribosylation factor-like protein 6-interacting protein 1 1 290857400.0 18115000.0 111739300.0 161003100.0 True False 27481779.383894194 91798548.89186439 129180766.7148345 1.0 3.3403422540268006 4.700596890408828 24.711972082676535 -8.554591197818636 0.2677215131403453 1.0327096444590278e-15 5.6138642817119795 0.999118151565057 0.04538494586117959 0.19389933345169721 0.07509951683779778 0.6482826191048736 0.49521505424942963 2.7887449842327637e-09 8.554591197818636 5.613864281711979 IFGSNK(ub)WTTEQQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFGSNKWTTEQQQR 14 1 H3BN98;H3BPJ2;Q15041-2;Q15041;Q15041-3 H3BN98 ARL6IP1 ADP-ribosylation factor-like protein 6-interacting protein 1 1 97271000.0 17430000.0 14187000.0 65654000.0 True False 23874342.02803896 13560171.429864723 50147877.386573754 1.0 0.5679809484985651 2.1004925424825585 24.508957637528898 -6.831428800710064 1.3215922156312232 0.7693827282870652 2.1429248144404096 0.908689491024488 0.19495812314276365 0.17905385063673465 0.6111375582058353 0.11581012416273273 0.26649478937736254 1.4742502133161147e-07 6.831428800710064 1.3735420861533445 up IFGSNK(ub)WTTEQQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFGSNKWTTEQQQR 14 1 H3BN98;H3BPJ2;Q15041-2;Q15041;Q15041-3 H3BN98 ARL6IP1 ADP-ribosylation factor-like protein 6-interacting protein 1 1 83816700.0 11874000.0 21776000.0 50166700.0 True False 9873757.107390454 21658688.36580244 60656325.02538668 1.0 2.193560984965999 6.14318585779123 23.235167724806935 -6.949227654279486 0.5672588487960477 0.9501750344413579 7.577698045679116 0.9991392758068134 0.0644819202664873 0.08379735685654377 0.037257276683617765 0.06853018605072268 0.3288635825621291 1.1240156179995921e-07 6.949227654279486 6.627523011237758 IFGSNK(ub)WTTEQQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFGSNKWTTEQQQR 14 1 H3BN98;H3BPJ2;Q15041-2;Q15041;Q15041-3 H3BN98 ARL6IP1 ADP-ribosylation factor-like protein 6-interacting protein 1 1 249035600.0 18115000.0 94299400.0 136621200.0 True False 23450224.60003426 89051555.49416538 111757543.45189176 1.0 3.797471325457381 4.765734459179913 24.483098404768985 -9.298495530351294 0.3495809115650264 1.786031576518305e-24 5.01940231725 0.9982864978607751 0.06609322092572457 0.6861956382010956 0.135396647535269 1.1710452468838093 0.28216718075160185 5.029264418152481e-10 9.298495530351294 5.01940231725 IFGTDSQYNAYNEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFGTDSQYNAYNEKR 15 1 Q15800;Q15800-2 Q15800 MSMO1 Methylsterol monooxygenase 1 1 57349900.0 12858900.0 13780000.0 30711000.0 True False 16858142.425764736 11724077.714019304 27533320.32071382 1.0 0.6954548975752567 1.6332357163286233 24.00694224077743 -6.819263540032324 1.3750739265882637 0.8357301239291548 1.653384587179803 0.8826806900515317 0.13379051971594966 0.19443812270122854 0.7226121771465317 0.07646287056829258 0.17626876095882188 1.5161300651321953e-07 6.819263540032324 0.8176544632506482 IFGTDSQYNAYNEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFGTDSQYNAYNEKR 15 1 Q15800;Q15800-2 Q15800 MSMO1 Methylsterol monooxygenase 1 1 96792000.0 14324000.0 15388000.0 67080000.0 True False 13869292.460561192 21532508.6473599 49509735.64313577 1.0 1.552531155326768 3.569737662099344 23.725390854924516 -6.946974969970526 0.5911221060226298 0.9767606995283994 4.247207017000756 0.9989420060818278 0.03592371437613957 0.08472366809444141 0.041168264222143994 0.03720048878845767 0.16904875352313117 1.1298610309502213e-07 6.946974969970526 3.2704463174723566 IFGTDSQYNAYNEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFGTDSQYNAYNEKR 15 1 Q15800;Q15800-2 Q15800 MSMO1 Methylsterol monooxygenase 1 1 78956900.0 12858900.0 13067000.0 53031000.0 True False 17613182.82870627 12489656.733209431 40506170.007728316 1.0 0.7091084476142253 2.299764352738715 24.070152302300322 -6.859539258945542 1.1881782186088945 0.8423774858177021 2.376070024234133 0.9530625994889299 0.149824919644577 0.14728071589740957 0.39537933731652064 0.09837109304579619 0.22949195799396954 1.3818494851204967e-07 6.859539258945542 1.5336925384164308 up IFGTDSQYNAYNEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFGTDSQYNAYNEKR 15 1 Q15800;Q15800-2 Q15800 MSMO1 Methylsterol monooxygenase 1 1 88997270.0 14324000.0 21455000.0 53218270.0 True False 11911040.66079341 21339417.656515945 64345964.20352121 1.0 1.7915661833610512 5.402211782831328 23.505796130358792 -6.941872088342871 0.641910208681915 0.9604170046200977 6.431966737287073 0.9983989798130344 0.07666826167860123 0.08692284617378859 0.050797463508426004 0.07573540188747603 0.3082886365472026 1.1432149934350413e-07 6.941872088342871 5.4715497326669755 IFGTDSQYNAYNEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFGTDSQYNAYNEKR 15 1 Q15800;Q15800-2 Q15800 MSMO1 Methylsterol monooxygenase 1 1 279020400.0 13293000.0 83561300.0 182166100.0 True False 17208050.544203978 78911040.19871382 149013738.98202938 1.0 4.585704812756531 8.659536337323244 24.036580331635435 -6.97300329438541 0.2711880381952312 2.336754781535791e-10 13.353600250948036 0.9999781872992844 0.014614208753551421 0.07599510333182254 0.009643259159832492 0.07916095643499796 0.3762011275341804 1.0641349460887428e-07 6.97300329438541 13.35360025071436 IFGVTTLDIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFGVTTLDIVR 11 0 P40926;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 78779000.0 10077000.0 54573000.0 14129000.0 False True 13211044.585806806 46430921.1238879 12667066.614938129 1.0 3.514553358919902 0.9588240000754297 23.655241207948613 -6.6499149394124695 2.009193198696154 2.631822037348921 0.969633982256709 0.19362730255034488 1.073264563419121 0.5086944985730697 3.93618452807515 0.4332743346669441 1.188515841206518 2.23915965573343e-07 6.6499149394124695 -1.662188055092212 IFGVTTLDIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFGVTTLDIVR 11 0 P40926;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 45328600.0 25978000.0 10407000.0 8943600.0 False True 25153342.6096383 14562569.371788042 6601002.857751173 1.0 0.5789516565566889 0.2624304435475621 24.58424679569022 -7.9705083036528555 0.26153020134906 1.1605099018408171 3.210495622624084e-14 0.999552253473508 0.006392815686214186 0.10392296117867032 0.04704546988420651 0.06242095901227009 0.09320549753871943 1.0702659193734202e-08 7.9705083036528555 -1.160509901840785 down IFGVTTLDIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFGVTTLDIVR 11 0 P40926;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 136237000.0 22161000.0 69997000.0 44079000.0 False True 33619857.18611532 57505488.460942805 35366766.32948801 1.0 1.7104620088836078 1.0519606354572544 25.002810260370364 -10.46308241797102 5.36637799828214 0.9994989707415437 1.3812113221704336 0.3088409831268555 0.26883205996942405 0.0016135437289612775 0.00016143838263832846 0.26062756700854517 0.08676517426568309 3.4428458816514906e-11 10.46308241797102 0.38171235142888993 IFGVTTLDIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFGVTTLDIVR 11 0 P40926;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 77668000.0 10077000.0 34619000.0 32972000.0 False True 13802739.220685516 33089418.110276096 25184692.679655645 1.0 2.397308069161123 1.8246155547090632 23.718451269471505 -9.943460470609951 5.743820352662968 0.9999990513160802 2.1109618119359737 0.8338201376844723 0.23380073998962156 2.8405073010961813e-06 5.220995051414446e-07 0.2263767853162811 0.07545886435877686 1.1390414524648671e-10 9.943460470609951 1.1109627606198935 IFGVTTLDIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFGVTTLDIVR 11 0 P40926;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 57375000.0 25978000.0 14765000.0 16632000.0 False True 21601858.020531382 14685458.014376964 20109674.302320708 1.0 0.6798238373948778 0.9309233623889003 24.364652071124496 -9.855841714186312 5.893994499845741 1.0000000351187015 0.8053736012002868 0.4447631140720124 0.10251095181601354 4.734583866797191e-08 9.159237261402159e-09 0.09925582004472112 0.03308526743214041 1.393664654547731e-10 9.855841714186312 -0.19462643391841472 IFGVTTLDIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFGVTTLDIVR 11 0 P40926;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 129373000.0 22161000.0 64410000.0 42802000.0 False True 28687851.35861767 60825526.87905952 35012475.18560714 1.0 2.120253835628853 1.2204634898559452 24.773936582462813 -10.26781746819796 4.477743140210356 0.9996603617932741 1.6703586626560676 0.42530919838872006 0.3673378705378443 0.0012951571040585549 0.0002117802272778062 0.35585582733118726 0.11855778790380853 5.3973742379404124e-11 10.26781746819796 0.6706983008627935 IFHELTQTDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFHELTQTDK 10 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 3738560.0 1337700.0 685360.0 1715500.0 False True 1295235.4457199594 959027.8221051854 1266159.0861031509 1.0 0.7404274066728522 0.9775512940810183 20.30478294175169 -10.392319449101974 7.700092684513086 1.000002951585343 0.8589893504788333 0.32042647922136036 0.09680542166252931 4.905196199131003e-06 3.8709901465131957e-07 0.09373340723679968 0.031243815493463566 4.0521036977354655e-11 10.392319449101974 -0.14101360110650973 IFHGLK(ub)STDVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFHGLKSTDVAK 12 1 P13796;Q5TBN3 P13796 LCP1 Plastin-2 1 3982400.0 1193700.0 938900.0 1849800.0 True False 1155806.6468983453 1313807.6662988167 1365281.8871895152 1.0 1.1367019473581275 1.1812372690997281 20.140468641131523 -13.999999999999998 0.15682383827850693 0.33108271591853455 1.2265890410213454 0.9995450801693186 0.001644721953229941 11.989838724842278 0.12502815416883578 2.440388056809783 0.04117497446001342 1.0000000000000041e-14 13.999999999999998 0.8955063251028108 IFHGLK(ub)STDVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFHGLKSTDVAK 12 1 P13796;Q5TBN3 P13796 LCP1 Plastin-2 1 4819000.0 1193700.0 2531000.0 1094300.0 True False 992614.4398763682 2517365.0006358353 1323113.0705284728 1.0 2.5360954863293923 1.3329577098367305 19.9208739165658 -6.584811717558989 2.248853972419371 2.043011092945279 1.3362159247722687 0.0 0.6665208224121406 0.6848909673628589 6.522204799725706 0.24818265484478536 0.7438454886001947 2.6012870712209557e-07 6.584811717558989 -0.7067951681730102 IFHLEVCSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFHLEVCSR 9 0 O75886-2;O75886;Q92783;Q92783-2 O75886-2;Q92783 STAM2;STAM Signal transducing adapter molecule 2;Signal transducing adapter molecule 1 0 20625100.0 13211000.0 0.0 7414100.0 False True 17319748.935505986 0.0 6646960.0530690765 1.0 0.0 0.38377923824534294 24.04591468133589 -10.66120899114854 6.597426567096513 1.004702425060416 0.1918896191226813 0.8553191529323999 0.15667721792918485 0.010844472260284971 0.0005568846495693402 0.15180838715405767 0.05056735464748691 2.1816797914558048e-11 10.66120899114854 -0.8128128059377346 IFHLSVPQIHVNLDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFHLSVPQIHVNLDK 15 0 Q9UKA4 Q9UKA4 AKAP11 A-kinase anchor protein 11 0 9846000.0 3771900.0 2960700.0 3113400.0 False True 5722248.062826963 2432339.9529453185 2498035.1253483016 1.0 0.4250671984576057 0.43654785635318943 22.448150610021454 -9.966179094683415 5.246689850604673 1.0000021070971008 0.4308075274103997 0.9996949685027493 0.004686958970546342 2794432.3579370785 5308071.859005832 45.271056693388495 0.0016044709401431048 1.0809880806964459e-10 9.966179094683415 -0.5691945796867011 IFHVNWFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFHVNWFR 8 0 H0YML5;Q16822-3;P35558;Q16822;P35558-2 H0YML5 PCK2;PCK1 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial;Phosphoenolpyruvate carboxykinase, cytosolic [GTP] 0 2104370.0 1364700.0 0.0 739670.0 False True 1321378.3454990117 0.0 545928.2373756447 1.0 0.0 0.41315058570108304 20.33361217672944 -10.730985501173585 6.709073129420604 1.0124356295080708 0.20657529285054765 0.8310061801597042 0.16866802031661088 0.030729861637636944 0.0012321775029390542 0.1599609943755069 0.054437369477000695 1.857866478522944e-11 10.730985501173585 -0.8058603366575231 IFHVNWFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFHVNWFR 8 0 H0YML5;Q16822-3;P35558;Q16822;P35558-2 H0YML5 PCK2;PCK1 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial;Phosphoenolpyruvate carboxykinase, cytosolic [GTP] 0 4322300.0 1364700.0 1901700.0 1055900.0 False True 1134808.516460818 1891455.1646421053 1276683.808070011 1.0 1.6667615172126815 1.1250213490216536 20.114017452163715 -10.182426279366203 3.7885269528671652 0.9996921718299369 1.3958914329926195 0.41590399655383603 0.22116449846659128 156432933.55988038 249798132.69191936 580134.8305280716 0.08093789899594477 6.570126336129274e-11 10.182426279366203 0.39619926116268267 IFHVNWFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFHVNWFR 8 0 H0YML5;Q16822-3;P35558;Q16822;P35558-2 H0YML5 PCK2;PCK1 Phosphoenolpyruvate carboxykinase [GTP], mitochondrial;Phosphoenolpyruvate carboxykinase, cytosolic [GTP] 0 16647400.0 2016300.0 7799900.0 6831200.0 False True 2610140.097214962 7365828.708336851 5587991.694031106 1.0 2.822005116199028 2.140878070105713 21.315695813718154 -10.312847448490931 5.5707827735121755 0.9997798559575426 2.4814415931523928 0.863152741552401 0.27806895215637556 0.000760393563469601 9.379403601875958e-05 0.2692769349843796 0.08974636839990431 4.8657809247473406e-11 10.312847448490931 1.4816617371948502 IFIGTFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFIGTFK 7 0 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3;J3KRY3;S4R3P3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 85552000.0 28150000.0 19482000.0 37920000.0 False True 36904922.60498775 16575361.540241217 33996402.15432476 1.0 0.4491368730848127 0.921188821291014 25.137309928847912 -10.214445048954532 7.921088769005775 1.0000001886407333 0.6851628471879154 0.3722947226072326 0.1927144008653177 6.420096423319569e-07 6.371067318415822e-08 0.18659502888872564 0.06219830542714295 6.103162747469145e-11 10.214445048954532 -0.31483734145281783 IFIGTFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFIGTFK 7 0 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3;J3KRY3;S4R3P3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 45170100.0 18715000.0 5375100.0 21080000.0 False True 18120902.569073047 7521405.460776209 15558515.613555478 1.0 0.41506792678268656 0.8585949598398704 24.111151479391314 -9.858455888280984 6.4252614036249485 1.0000000168030814 0.6368314433112509 0.47200398793829923 0.1810691530202744 4.345954849094532e-08 7.725259209486544e-09 0.17531946137715576 0.05843981784659208 1.385300885156549e-10 9.858455888280984 -0.3631685734918305 IFIGTFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFIGTFK 7 0 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3;J3KRY3;S4R3P3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 52070800.0 12872000.0 31073000.0 8125800.0 False True 19527765.069251202 25527780.37554292 6519732.068335341 1.0 1.3072556068251486 0.33386985378072975 24.21902350805933 -6.821816576541422 1.3638661086320012 1.1653082912658188 0.3117524370433874 0.8885579392899214 0.13563022421009668 0.19111477345875216 0.6980141810844538 0.07813533313384545 0.18001962387615184 1.507243513242524e-07 6.821816576541422 -0.8535558542224314 down IFIGTFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFIGTFK 7 0 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3;J3KRY3;S4R3P3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 37783800.0 18715000.0 11797000.0 7271800.0 False True 15562351.715075983 11733447.219478825 8792299.75899566 1.0 0.7539636318662611 0.5649724360411509 23.89155675482559 -6.974061599016708 0.1282407101093264 1.3004506275988426 0.013600496358426088 0.9999992641069507 0.0001526789911372589 0.07500548587790024 0.003844294524308038 0.012124088055716903 0.026053107877494253 1.0615449801886907e-07 6.974061599016708 -1.2868501312404164 IFIGTFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFIGTFK 7 0 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3;J3KRY3;S4R3P3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 42956000.0 12872000.0 13572000.0 16512000.0 False True 16663057.745053304 12816706.269253174 13506985.427427351 1.0 0.7691689283773873 0.8105946479983313 23.99014983015178 -10.319475598107644 5.666292927303595 1.0000292693508694 0.7898817881878628 0.9716734057934563 0.016911979216491856 6.2541641179948465e-06 7.510932400941891e-07 0.016377232032422116 0.005458317821405674 4.792083776406903e-11 10.319475598107644 -0.21014748116300663 IFILGPSHHVPLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFILGPSHHVPLSR 14 0 Q9Y316;Q9Y316-3;Q9Y316-2 Q9Y316 MEMO1 Protein MEMO1 0 28449300.0 9751500.0 6868700.0 11829100.0 False True 12784310.933660347 5843916.733982891 10605138.20473954 1.0 0.45711628607187565 0.8295432002374746 23.607871066528947 -10.092946353326033 5.861790657256773 1.0000017191283528 0.6433297431546616 0.5501369020452188 0.15204265103091613 3.4158549253793234e-06 5.287948564947317e-07 0.14721537231541343 0.04907155461298554 8.073347509477512e-11 10.092946353326033 -0.35667197597369116 IFILGPSHHVPLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFILGPSHHVPLSR 14 0 Q9Y316;Q9Y316-3;Q9Y316-2 Q9Y316 MEMO1 Protein MEMO1 0 34009200.0 8879600.0 7447700.0 17681900.0 False True 8597721.958447292 10421605.449242411 13050479.944370352 1.0 1.2121356679839066 1.5178997422158098 23.035523025114657 -6.965911730643809 0.3420485406815582 0.9676127041036369 1.7726156442892926 0.9999307190601882 0.001769406159006125 0.07765297317067253 0.0137768675555759 0.004289793307478966 0.02642589845244775 1.0816537726036106e-07 6.965911730643809 0.8050029401856558 IFILGPSHHVPLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFILGPSHHVPLSR 14 0 Q9Y316;Q9Y316-3;Q9Y316-2 Q9Y316 MEMO1 Protein MEMO1 0 35104700.0 9751500.0 10696900.0 14656300.0 False True 13356893.074378788 10224275.588082036 11194783.795973469 1.0 0.7654681018368154 0.8381278291017631 23.67108112805184 -10.197094106307334 7.345390502461975 1.0000002508711854 0.8017979654692893 0.9084355844054104 0.029663209441485452 1.218625869619053e-07 1.3342757187334944e-08 0.028721315418334864 0.009573759680161322 6.351932783167436e-11 10.197094106307334 -0.1982022854018961 IFILGPSHHVPLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFILGPSHHVPLSR 14 0 Q9Y316;Q9Y316-3;Q9Y316-2 Q9Y316 MEMO1 Protein MEMO1 0 19255000.0 8879600.0 5082300.0 5293100.0 False True 7383780.832978291 5054920.641142438 6399862.7374707665 1.0 0.684597871400187 0.8667460319091492 22.815928300548933 -10.198069586075357 5.29527091712972 1.0000127187467545 0.7756719525558632 0.669131631485604 0.07436167513913128 1.1166266243242682e-05 1.6910962656247985e-06 0.07200446311722325 0.024000127450798152 6.337681558059251e-11 10.198069586075357 -0.22434076619089127 IFILGPSHHVPLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFILGPSHHVPLSR 14 0 Q9Y316;Q9Y316-3;Q9Y316-2 Q9Y316 MEMO1 Protein MEMO1 0 16011800.0 1468900.0 6959800.0 7583100.0 False True 1901520.0063477955 6572481.011844106 6203053.609176607 1.0 3.456435372703606 3.2621553223048467 20.85872168731288 -9.837953510903432 9.100073663568113 0.9999999998705497 3.3592953475042266 0.9949400065778229 0.07931449844652667 0.0 0.0 0.07679593347122218 0.025598644299682626 1.4522670673420572e-10 9.837953510903432 2.359295347633677 IFINLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFINLPR 7 0 O43396;K7ER96 O43396 TXNL1 Thioredoxin-like protein 1 0 22860300.0 4856100.0 6657200.0 11347000.0 False True 6366394.126539291 5663971.709562356 10172921.288109774 1.0 0.8896671486220465 1.5979094422857658 22.602045042478178 -6.867106241935947 1.1493596503701435 0.9385741149585307 1.6371574426615156 0.9617052276641531 0.06088725727697231 0.13965609026925652 0.3466331944569647 0.04118243003991583 0.09703588697565008 1.357981201517732e-07 6.867106241935947 0.6985833277029849 IFINLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFINLPR 7 0 O43396;K7ER96 O43396 TXNL1 Thioredoxin-like protein 1 0 17946500.0 7913700.0 3232200.0 6800600.0 False True 7662483.925240378 4522834.315700326 5019318.846373127 1.0 0.5902569401551392 0.6550511420767081 22.86938071156964 -10.60621786848228 6.4857877135471 1.0010537859234585 0.6226540411159399 0.9783650889162808 0.026452122166450865 0.000404092559858724 2.4534322984914814e-05 0.025677310617675097 0.00853738571854235 2.476179543987469e-11 10.60621786848228 -0.3783997448075186 IFINLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFINLPR 7 0 O43396;K7ER96 O43396 TXNL1 Thioredoxin-like protein 1 0 25067500.0 4856100.0 10426000.0 9785400.0 False True 6651531.401168099 9965344.845828561 7474290.05663904 1.0 1.498203082087008 1.1236946209599874 22.66525510400107 -10.609325652641832 11.202602026113915 0.9999869347764526 1.3109488515234975 0.47894000429880734 0.15289243901935826 4.98936061929261e-05 1.739866219954186e-06 0.14804367168418409 0.049345822506917277 2.4585234064382677e-11 10.609325652641832 0.3109619167470449 IFINLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFINLPR 7 0 O43396;K7ER96 O43396 TXNL1 Thioredoxin-like protein 1 0 13861800.0 7913700.0 3195700.0 2752400.0 False True 6580592.186353035 3178484.129803211 3327914.1143402746 1.0 0.4830088295692925 0.5057165100189266 22.649785987003916 -10.135209464118555 5.235030803954771 1.000015018758545 0.49436266979373567 0.9984896684437634 0.00927037172533334 1.6250439944301176e-06 2.684397547777597e-07 0.00897626509722142 0.0029919996085832385 7.32471170524561e-11 10.135209464118555 -0.5056523489648094 IFINLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFINLPR 7 0 O43396;K7ER96 O43396 TXNL1 Thioredoxin-like protein 1 0 10971200.0 3587900.0 3890500.0 3492800.0 False True 4644607.278082408 3673990.2549756477 2857146.239154444 1.0 0.7910228002080957 0.6151534603662029 22.147125184895373 -6.973117788915146 0.16775139124292518 1.1601703974679958 0.24130608186731992 0.9999976073739575 0.00024325519473865603 0.0753034167983778 0.0052200596354839805 0.00756705160013217 0.020531491229262868 1.0638544415544197e-07 6.973117788915146 -0.9188643156006758 IFLAQK(ub)PAPLLESPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFLAQKPAPLLESPFK 16 1 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 1 16767500.0 4807200.0 4668400.0 7291900.0 True False 4654598.0673282435 6532516.465384382 5381932.637689059 1.0 1.4034544703736516 1.1562615202945563 22.150225163250493 -10.137343196856175 4.176389984300249 0.9999383789453253 1.279857995152032 0.6308600668956001 0.10091609953158923 71063419.80442119 88801921.61901341 59510.03653975508 0.03693151651161918 7.288812914827395e-11 10.137343196856175 0.2799196162067066 IFLAQK(ub)PAPLLESPFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFLAQKPAPLLESPFK 16 1 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 1 15995000.0 4807200.0 9077000.0 2110800.0 True False 3997399.795068841 9028100.399356559 2552158.520763501 1.0 2.2584932361515473 0.6384546584286672 21.93063043868477 -6.6993348068901115 1.8331648903471776 1.7819600883962785 0.6433145435741997 0.41452796143519 0.5312866635123618 0.3968691267060781 2.5923758190976 0.23124984546464195 0.5952193604135547 1.998320727537992e-07 6.6993348068901115 -1.138645544822079 IFLFDTQHFISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFLFDTQHFISK 12 0 Q9H583;Q5T3Q7 Q9H583 HEATR1 HEAT repeat-containing protein 1;HEAT repeat-containing protein 1, N-terminally processed 0 2448600.0 659230.0 1016400.0 772970.0 False True 864256.913992401 864757.0818961693 692990.4792518048 1.0 1.0005787259502015 0.8018338853091291 19.721100714425962 -6.90624362281681 0.9209457933986803 1.006908161923094 0.7781116004244008 0.9894248856530955 0.009620567195031076 0.1069544263768879 0.15263318677941837 0.007733030746821827 0.020829685009181684 1.2409559828242085e-07 6.90624362281681 -0.2287965614986932 IFLFDTQHFISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFLFDTQHFISK 12 0 Q9H583;Q5T3Q7 Q9H583 HEATR1 HEAT repeat-containing protein 1;HEAT repeat-containing protein 1, N-terminally processed 0 2351500.0 659230.0 726050.0 966220.0 False True 902965.1460208908 693970.7102737208 738018.7359255388 1.0 0.7685465085024059 0.8173280432559068 19.784310775948853 -10.681216067668485 6.697615421145209 1.0015170843983159 0.7929372758791566 0.960037153610599 0.01991497816932026 0.00045419783754307346 2.1618277888373254e-05 0.019413278891110695 0.006427531565821796 2.0834540772329472e-11 10.681216067668485 -0.20857980851915925 IFMEK(ub)GDMVTLPAGIYHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFMEKGDMVTLPAGIYHR 18 1 Q9BV57;Q9BV57-2;A0A0G2JQN5 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 33453400.0 4593200.0 5020200.0 23840000.0 True False 5945987.945507997 4740821.456889528 19501364.619056933 1.0 0.797314340415215 3.2797517919271244 22.503485107750784 -6.887105560856867 1.039312043376418 0.8572150604716373 3.481569942994408 0.9789816311453836 0.1631724288357823 0.12152471239585758 0.2357967028899677 0.12005310304934043 0.2963505975856395 1.2968640132016327e-07 6.887105560856867 2.6243548825227707 up IFNDK(ub)TVGGEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFNDKTVGGEAR 12 1 Q99707;Q99707-2;B1ANE3 Q99707 MTR Methionine synthase 1 8063100.0 2353900.0 3663800.0 2045400.0 True False 3085985.695200029 3117175.3213805417 1833761.628862234 1.0 1.0101068602583043 0.594222336064125 21.5572999437695 -6.901329928515678 0.9528095762537598 1.0166656595591317 0.5493678380931152 0.9872167730163522 0.02190159918969353 0.11043336628040777 0.1719449301045042 0.01719559171662027 0.04504665434680696 1.2550761345508472e-07 6.901329928515678 -0.4672978214660165 IFNDK(ub)TVGGEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFNDKTVGGEAR 12 1 Q99707;Q99707-2;B1ANE3 Q99707 MTR Methionine synthase 1 17252800.0 4509100.0 3313300.0 9430400.0 True False 6840634.359366122 2722015.7280689417 7566477.306508852 1.0 0.3979186117939468 1.1061075492434287 22.705698687516612 -6.681444006227844 1.8964480398486934 0.6195611437228796 1.1034643408999552 0.33089942497591673 0.25509445645936224 0.43531335030071394 3.0281045451816735 0.10787683105443514 0.2840247941398587 2.0823608675850615e-07 6.681444006227844 0.48390319717707553 IFNDK(ub)TVGGEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFNDKTVGGEAR 12 1 Q99707;Q99707-2;B1ANE3 Q99707 MTR Methionine synthase 1 7001100.0 2353900.0 2553200.0 2094000.0 True False 3224200.44175565 2440391.181696665 1599440.3272837237 1.0 0.7568980979258897 0.4960734781156448 21.62051000529239 -6.970229417433981 0.25264819279606027 1.0801231289495554 0.1651833985252767 0.9999841159557943 0.0008200699184342658 0.07622836428068402 0.0087634748658501 0.005714520855322267 0.02489084900708671 1.0709534212529624e-07 6.970229417433981 -0.9149397304242788 down IFNSFLHTALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFNSFLHTALK 11 0 Q5GLZ8-6;Q5GLZ8-3;Q5GLZ8-2;Q5GLZ8 Q5GLZ8-6 HERC4 Probable E3 ubiquitin-protein ligase HERC4 0 2589050.0 618030.0 743520.0 1227500.0 False True 846532.3926327548 710668.8279081567 937589.7811560499 1.0 0.8395057697649866 1.1075651555873751 19.69120574846028 -6.744522981603803 1.6698726912714015 0.9050129227444518 1.107891402395491 0.6252054717583426 0.06743041771032714 0.3096812395559681 1.6971400910363754 0.03192190060266082 0.07795596960334929 1.8008478362784646e-07 6.744522981603803 0.20287847965103933 IFNTNNLWISLAAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFNTNNLWISLAAVK 15 0 A0A087WYS1;E7EUC7;Q16851-2;Q16851 A0A087WYS1 UGP2 UTP--glucose-1-phosphate uridylyltransferase 0 153816000.0 46700000.0 54441000.0 52675000.0 False True 70847314.22731754 44725578.20052557 42263763.161727384 1.0 0.6312953241533061 0.5965471468138052 26.07820982682027 -13.999999999999998 0.3340945629595721 5.114101491522786 0.5906843901332804 0.9997232760137151 0.0030367394867369113 19.175063412662574 0.18506014815272465 55.548744714288766 0.010967769448052252 1.0000000000000041e-14 13.999999999999998 -4.523417101389505 IFNTNNLWISLAAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFNTNNLWISLAAVK 15 0 A0A087WYS1;E7EUC7;Q16851-2;Q16851 A0A087WYS1 UGP2 UTP--glucose-1-phosphate uridylyltransferase 0 133384000.0 46700000.0 46325000.0 40359000.0 False True 60454070.59462316 43746973.0270522 33014076.118310302 1.0 0.7236398243618536 0.5461017892357872 25.84933614891272 -8.816178625546213 0.10105489276975009 1.601416237796433 1.2409543682723458e-12 0.99996944710861 0.0010323011681966608 0.33512381513619577 0.029448329512095292 0.25089119986837577 0.19586188755505823 1.5269378987141048e-09 8.816178625546213 -1.601416237795192 IFPAALQLVASGTVQLGENGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFPAALQLVASGTVQLGENGK 21 0 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 49895000.0 11223000.0 19932000.0 18740000.0 False True 17026111.511203103 16374978.8705732 15036030.785966203 1.0 0.9617568203872352 0.8831159584543167 24.021245648607866 -6.95949884888919 0.4424541054472876 1.002740991433708 0.839053243185049 0.999751105687989 0.0007676327583271602 0.07988084148092695 0.02179778747013752 0.0010400784319762307 0.00651292778241505 1.0977441998744409e-07 6.95949884888919 -0.16368774824865895 IFPAALQLVASGTVQLGENGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFPAALQLVASGTVQLGENGK 21 0 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 26816400.0 11223000.0 5726700.0 9866700.0 False True 14528394.73840377 5408004.110826123 8071061.840891308 1.0 0.37223686499450787 0.5555370697325969 23.792371970700316 -10.366759362884887 5.033912591527082 1.0003479992822328 0.46388696736349144 0.9193925100479873 0.07483199522626786 0.0002924473696986636 3.6788332901965e-05 0.07250160359427761 0.024151922606195777 4.297744934502264e-11 10.366759362884887 -0.5364610319187414 IFQAALYAAPYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFQAALYAAPYK 12 0 Q9NZD2;H0YFS9;F5H0U5 Q9NZD2 GLTP Glycolipid transfer protein 0 6181000.0 2569800.0 1658800.0 1952400.0 False True 3519924.5062337625 1585508.7310819498 1491283.3309401823 1.0 0.45043827737612685 0.4236691236698769 21.747113056240686 -13.755845669944758 0.432986412982248 9.99999999984639 0.42320354705820834 0.9998763677814043 0.002953205430377112 25.819177340567826 0.22103018450027534 219.17870597433063 0.006291419948305836 1.7545038682100937e-14 13.755845669944758 -9.576796452788182 IFQGNVHNFEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFQGNVHNFEK 11 0 Q96DI7;Q96DI7-2;Q9NSS8 Q96DI7 SNRNP40;DKFZp434D199 U5 small nuclear ribonucleoprotein 40 kDa protein 0 4288430.0 637830.0 1772000.0 1878600.0 False True 836201.3067545074 1507624.507201902 1684220.492803651 1.0 1.8029444525186704 2.0141328161044187 19.673490772359372 -10.838667785895753 0.26376583329948144 2.807016265300498e-14 2.1056362773166932 0.9991905130791174 0.012429913502463053 2.6586802926918183 0.13601079556345724 1.7472798932742803 0.08974781258034766 1.4498805173593999e-11 10.838667785895753 2.1056362773166653 IFQGNVHNFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFQGNVHNFEK 11 0 Q96DI7;Q96DI7-2;Q9NSS8 Q96DI7 SNRNP40;DKFZp434D199 U5 small nuclear ribonucleoprotein 40 kDa protein 0 3949590.0 1193400.0 993490.0 1762700.0 False True 1155516.170234132 1390195.7379819085 1300995.9901335035 1.0 1.2030950096528943 1.1259002891062044 20.140106018271528 -10.199759422955307 4.515957895596517 0.9999599772490589 1.1644976493818484 0.8582478069775701 0.031514612703841094 1.2702112803069404e-05 2.2508663735346025e-06 0.030521311390971126 0.010171297512580581 6.313069595694687e-11 10.199759422955307 0.16453767213278947 IFQGNVHNFEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFQGNVHNFEK 11 0 Q96DI7;Q96DI7-2;Q9NSS8 Q96DI7 SNRNP40;DKFZp434D199 U5 small nuclear ribonucleoprotein 40 kDa protein 0 3670230.0 637830.0 1135500.0 1896900.0 False True 873652.9877076371 1085329.8554036361 1448891.2878818044 1.0 1.242289410869428 1.6584288135768013 19.736700833882264 -6.96290968657882 0.3922804652700321 0.9750827290114615 1.9406425007330206 0.9998633556677001 0.003178460074647205 0.07867768665168617 0.017407358429000475 0.005366561641399619 0.03497148589669665 1.0891565646163915e-07 6.96290968657882 0.965559771721559 IFQIHTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFQIHTSR 8 0 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 0 4110600.0 1675900.0 831600.0 1603100.0 False True 2197121.129438687 707528.5215514116 1437226.5900210442 1.0 0.32202526846217555 0.6541408076068259 21.067182978467823 -10.585476247258464 6.542458275554942 1.0009935624351993 0.488083038034883 0.7600659462572401 0.13558560109228768 0.0019683217101875467 0.000124710461024832 0.13150544074331935 0.04376006458466272 2.5973097914249336e-11 10.585476247258464 -0.5129105244003163 IFQNAPTDPTQDFSTQVAK(ub)LGHGLLSGEYSKPVPESGDGERVPEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFQNAPTDPTQDFSTQVAKLGHGLLSGEYSKPVPESGDGERVPEQK 46 3 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 118475000.0 13868000.0 36735000.0 67872000.0 True False 21038769.886604726 30179352.23813494 54457069.45064556 1.0 1.4344637258164972 2.588415090053249 24.32654701853872 -6.954151564432604 0.5112398066982471 0.9789771519685221 3.09463434111949 0.9994880933603304 0.01516522261841177 0.08186028727981282 0.029385414676638057 0.017430218407924587 0.09524644691778437 1.1113438117158581e-07 6.954151564432604 2.115657189150968 up IFQNK(ub)EPLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFQNKEPLIR 10 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 6021900.0 1495800.0 2671600.0 1854500.0 True False 1448316.647759525 3738383.812209952 1368750.816192535 1.0 2.581192322820461 0.945063234831917 20.465945624929287 -6.653933212747184 1.994309481153152 2.022820692517348 0.951911914876503 0.2102169989318663 0.6742204839261136 0.49897297807822116 3.8082382371024432 0.2737465222386488 0.7470584913472469 2.2185375676690764e-07 6.653933212747184 -1.0709087776408452 IFQNK(ub)EPLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFQNKEPLIR 10 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 6668000.0 1495800.0 2968200.0 2204000.0 True False 1243823.9751755649 2952209.7174584316 2664846.2098553865 1.0 2.373494784132722 2.1424624890987856 20.246350900363563 -10.21502953637508 4.681278894708136 0.9997339234190176 2.257978636622159 0.9753276423912378 0.0943185395115015 0.00026197430602353946 4.3928924233512724e-05 0.09134207786279082 0.030441177727448015 6.094954440350815e-11 10.21502953637508 1.2582447132031414 IFQNK(ub)EPLIRPTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFQNKEPLIRPTAR 14 2 P59045-2 P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 15762200.0 7147200.0 3752700.0 4862300.0 True False 6920316.048179489 5251172.680071972 3588717.7641267 1.0 0.7588053267384206 0.5185771486651647 22.722406496019886 -6.971174881102087 0.22838857298978693 1.0996905188637365 0.17084115540963823 0.9999901516840558 0.0006167559190205303 0.07592326291577439 0.007652033232248228 0.006246534535804257 0.023934704276448355 1.0686244803425948e-07 6.971174881102087 -0.9288493634540982 IFQNK(ub)EPLIRPTAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFQNKEPLIRPTAR 14 2 P59045-2 P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 35326700.0 7993700.0 11236000.0 16097000.0 True False 12127027.317749647 9230848.012731314 12915420.894434255 1.0 0.7611797822225271 1.0650112806731027 23.5317226120701 -6.697092320530641 1.8412695821683729 0.8512826010411076 1.0640593279209007 0.40380429928380224 0.10086340574435268 0.401586670122891 2.6448557575245477 0.04373632008617542 0.1128824774188911 2.008665773331579e-07 6.697092320530641 0.2127767268797931 IFQNK(ub)EPLIRPTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFQNKEPLIRPTAR 14 2 P59045-2 P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 17698800.0 7147200.0 8198900.0 2352700.0 True False 5943213.474645539 8154730.898345768 2844638.6923442725 1.0 1.3721080242422432 0.4786364656897892 22.502811771454162 -6.793628647010996 1.482206960780554 1.2069946810410668 0.46821432240715577 0.8127477779512833 0.15857297411040555 0.2299856214056677 0.9981045941598325 0.08419980834922146 0.1965897031642828 1.6083158908770506e-07 6.793628647010996 -0.738780358633911 down IFQNK(ub)EPLIRPTAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFQNKEPLIRPTAR 14 2 P59045-2 P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 27577100.0 7993700.0 11225000.0 8358400.0 True False 10348002.229384143 10600318.882431988 6837256.964426403 1.0 1.0243831270475925 0.6607320729996904 23.30284893416255 -6.890859817507435 1.017301911006608 1.0191385950948753 0.6289249823741847 0.9814422497638982 0.022610706114555342 0.11844753082785212 0.21780444306465968 0.01691607406797238 0.042303914344510356 1.2857015944566545e-07 6.890859817507435 -0.39021361272069055 IFQNK(ub)EPLIRPTASQMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 IFQNKEPLIRPTASQMK 17 2 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 26096200.0 6523600.0 10059100.0 9513500.0 True False 8552502.774632258 8558321.490064692 8529134.279935876 1.0 1.0006803523583403 0.9972676425471972 23.027915236361494 -6.8549363212643994 1.2115979831794108 1.00036509133569 0.9971180968339706 0.9471059835900489 0.0003391376629389677 0.1521067455190275 0.4272928531039426 0.00021876437781686848 0.0005079153436208775 1.3965731195656408e-07 6.8549363212643994 -0.0032469945017195023 IFQNK(ub)EPLIRPTASQMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFQNKEPLIRPTASQMK 17 2 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 19994200.0 6735500.0 7001700.0 6257000.0 True False 6521685.239326305 9797515.32338315 4618103.994023566 1.0 1.502298096863571 0.7081151304537077 22.636813382287094 -6.735743093147335 1.7019746171350179 1.300317881417525 0.7080379435330162 0.5858639224605976 0.21107597995201344 0.3255489693735493 1.849847297864391 0.09817334611007754 0.2420720546319113 1.8376250687963965e-07 6.735743093147335 -0.5922799378845087 IFQNK(ub)EPLIRPTASQMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFQNKEPLIRPTASQMK 17 2 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 50737000.0 11962000.0 16234000.0 22541000.0 True False 18147228.5393399 13336915.86317906 18085761.469928738 1.0 0.7349285227916232 0.996612867398572 24.113245899603236 -10.839408937915175 9.489562586405649 1.0040170568138553 0.865770695118573 0.25970608010613105 0.10683218632694327 0.009280072615655232 0.0001570456408642698 0.10572565306566208 0.03447993987359825 1.4474083112475347e-11 10.839408937915175 -0.13824636169528237 IFQNK(ub)EPLIRPTASQMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFQNKEPLIRPTASQMK 17 2 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 21599200.0 5248500.0 8026400.0 8324300.0 True False 7189012.285379377 7671767.108244614 6358271.784339966 1.0 1.0671517593379325 0.8844430266548681 22.777362138476857 -6.807250549761396 1.4263352710369546 1.0367177012043491 0.8814520980830106 0.8524507415677143 0.028985051608806277 0.21057942094198775 0.844901386364996 0.01598211156774861 0.03701339501159693 1.5586530375274782e-07 6.807250549761396 -0.15526560312133852 IFQNK(ub)EPLIRPTASQMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IFQNKEPLIRPTASQMK 17 2 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 27066700.0 7978500.0 12792700.0 6295500.0 True False 6634476.257479764 12723783.185947854 7611859.942896828 1.0 1.917827827268649 1.147318891120479 22.661551149379267 -10.14165679139296 4.238364848804016 0.9998813443649405 1.532573359237596 0.3891279937822627 0.31455895615984897 44792025.41447072 35726515.93878026 44927.13416599535 0.10768189642912458 7.216775718763323e-11 10.14165679139296 0.5326920148726556 IFQNK(ub)EPLIRPTASQMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IFQNKEPLIRPTASQMK 17 2 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 59173400.0 17581600.0 23399500.0 18192300.0 True False 22759727.78514834 22097297.25518636 14881488.068761297 1.0 0.970894619820794 0.6538517599701733 24.439979966787266 -6.92483835958626 0.7880078264178427 1.0058527542751245 0.5965667494250051 0.9954228526357934 0.010605982913742167 0.09540795431338966 0.0914690150398971 0.009380708078541203 0.029542771449254036 1.1889446593697346e-07 6.92483835958626 -0.40928600485011946 IFSAEIIYHLFDAFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFSAEIIYHLFDAFTK 16 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 2422240000.0 795660000.0 859680000.0 766900000.0 False True 1207074390.5376322 706263387.2895025 615321878.855789 1.0 0.5851034474974919 0.5097630135137934 30.16886744437296 -13.999999999999998 0.2399403028911412 3.7454241424511823 0.47643256100413467 0.9995248623351376 0.004698432246142715 13.621268887073548 0.1550341647471216 17.91755145752573 0.036826982330321785 1.0000000000000041e-14 13.999999999999998 -3.2689915814470476 IFSAEIIYHLFDAFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFSAEIIYHLFDAFTK 16 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 1329060000.0 795660000.0 533400000.0 0.0 False True 1029997554.8033797 503715821.10371685 0.0 1.0 0.4890456474917294 0.0 29.93999376646541 -7.963059727500546 0.5862740057044604 1.012341957704472 9.418576354328554e-19 0.9892726571568916 0.04228683599182666 0.11186052839408654 0.1631064304675274 0.045480502296518316 0.07663694182042995 1.0887803456315308e-08 7.963059727500546 -1.012341957704472 IFSAYIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFSAYIK 7 0 A0A1W2PNV4;O15143;C9JEY1;C9K057 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 31306400.0 10146000.0 8090400.0 13070000.0 False True 13301504.254003752 6883343.856132192 11717641.776292846 1.0 0.517486122222628 0.880926063137997 23.665086072124097 -9.75564261654973 6.037703488257022 1.0000000092301369 0.6992060926794473 0.47734168623261997 0.148373734568071 1.8432583379272912e-08 3.900171523407718e-09 0.14366225502929517 0.047887416915942935 1.7553243742921636e-10 9.75564261654973 -0.30079391655068954 IFSAYIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFSAYIK 7 0 A0A1W2PNV4;O15143;C9JEY1;C9K057 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 14706100.0 6569700.0 1887000.0 6249400.0 False True 6361148.469571962 2640488.9405750004 4612494.662018677 1.0 0.41509626024381685 0.7251040726501152 22.600855828823722 -10.073415299747431 5.27686573915952 1.0000055450340555 0.5701001664464143 0.7194210301660751 0.1265601594473231 8.25633795386617e-06 1.4499463663725079e-06 0.12254292639389099 0.04084711581911327 8.444709226243743e-11 10.073415299747431 -0.4299053785876412 IFSAYIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFSAYIK 7 0 A0A1W2PNV4;O15143;C9JEY1;C9K057 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 29464800.0 10146000.0 7793800.0 11525000.0 False True 13897250.385340398 7449444.14534995 8803032.364825645 1.0 0.5360372691570732 0.633436983628904 23.72829613364699 -10.066137483668285 6.413935749573547 1.0000004251957608 0.5847371263929859 0.9603748246521678 0.03976326692480279 2.417667159036579e-07 3.515253502874576e-08 0.03850065723168152 0.012833539215878728 8.58741628484525e-11 10.066137483668285 -0.4152632988027749 IFSAYIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFSAYIK 7 0 A0A1W2PNV4;O15143;C9JEY1;C9K057 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 15280700.0 6569700.0 5252000.0 3459000.0 False True 5462996.637057694 5223706.433559626 4182260.9073910103 1.0 0.956197995460062 0.7655616844098091 22.381261104257998 -6.942940876695813 0.6316128942348574 1.0020797822439675 0.7093772162884263 0.9985242655076965 0.00390968642661577 0.08645027939755724 0.04868995914875669 0.0038966507264452514 0.016207128312384307 1.1404050276733475e-07 6.942940876695813 -0.2927025659555412 IFSFAHQTISALIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFSFAHQTISALIK 14 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 77131930.0 24598000.0 31678930.0 20855000.0 False True 32248216.20737083 26952557.12750198 18697124.655285917 1.0 0.8357844339105354 0.5797878721432164 24.94271602505894 -6.964609210559915 0.3646978952099841 1.0209085346350733 0.3858266383427939 0.9999048596418438 0.0016865478808457224 0.07809382248560191 0.015329113593155974 0.0034039372216335103 0.02180546077448989 1.0849026985269449e-07 6.964609210559915 -0.6350818962922793 IFSFAHQTISALIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFSFAHQTISALIK 14 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 202172600.0 78165000.0 53779600.0 70228000.0 False True 75683694.86035782 75254074.7369091 51833180.005160086 1.0 0.9943234784686266 0.6848658763396297 26.17347918664406 -6.910875562922432 0.8897537503553706 1.0093181237115973 0.6441159040755235 0.9912477495937776 0.013774429006113644 0.10384180382249217 0.1356486897267795 0.011326359066532538 0.03145872975136587 1.22779097597946e-07 6.910875562922432 -0.3652022196360738 IFSFAHQTISALIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFSFAHQTISALIK 14 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 399012700.0 119509500.0 108503200.0 171000000.0 False True 181304648.8147666 89139956.22062899 137201775.04803744 1.0 0.49165841473651656 0.7567471432473433 27.433840676657663 -10.567000532613335 7.7896212438573205 1.0001592398333718 0.6242027789919299 0.7282283083965727 0.1082220202357841 0.00029940980929339726 1.6643253047126042e-05 0.10482906527030075 0.03492850683884283 2.7101883081476722e-11 10.567000532613335 -0.37595646084144196 IFSFAHQTISALIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFSFAHQTISALIK 14 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 156012000.0 24598000.0 38188000.0 93226000.0 False True 33692545.335955374 36500727.889171325 71207938.84973842 1.0 1.0833472961218862 2.113462730099767 25.00592608658183 -6.922970028524041 0.8023707836115412 0.9796130401962105 2.2914949738973904 0.9949675664491369 0.03592317685958788 0.09645486084007389 0.09678154071485165 0.03144906067551394 0.09705769698774529 1.194070506663939e-07 6.922970028524041 1.31188193370118 up IFSFAHQTISALIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFSFAHQTISALIK 14 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 237567000.0 78165000.0 66378000.0 93024000.0 False True 64997660.796629205 66020408.538998626 112474888.30562064 1.0 1.0157351469242792 1.7304451718276854 25.953884462078335 -6.911649760223586 0.8844218950120573 0.9790080264337461 1.826145280830632 0.9915292031177115 0.03135577791503679 0.10333803954271513 0.13292435000889932 0.025882464602022398 0.07229127738963222 1.2256041977698318e-07 6.911649760223586 0.8471372543968859 IFSFAHQTISALIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFSFAHQTISALIK 14 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 304628200.0 119509500.0 99923900.0 85194800.0 False True 154707403.63443494 94363047.12483256 69690220.57246773 1.0 0.6099452573569603 0.45046467677230156 27.204966998750113 -13.999999999999826 0.1229927079585246 2.855726188272777 0.20589316239355496 0.9996783924518906 0.004139668406206971 11.953269814274696 0.10830664516407452 5.4015852392025305 0.21710186589657818 1.0000000000004009e-14 13.999999999999826 -2.649833025879222 IFSFLLNTLQENVNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFSFLLNTLQENVNK 15 0 Q9HAV4 Q9HAV4 XPO5 Exportin-5 0 53503000.0 21925000.0 14271000.0 17307000.0 False True 33261827.932204213 11724228.550168078 13886263.864072427 1.0 0.35248298963198715 0.41748348564534843 24.98736411955534 -10.139602363765883 5.2456063537088715 1.0000188616484167 0.3849832376469462 0.9916919802325527 0.02653634137825865 5.8537182840785464e-06 9.60178692497152e-07 0.025694488826996945 0.008564567352056275 7.250995510548622e-11 10.139602363765883 -0.6150356240014705 IFSFLLNTLQENVNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFSFLLNTLQENVNK 15 0 Q9HAV4 Q9HAV4 XPO5 Exportin-5 0 101907000.0 65380000.0 14393000.0 22134000.0 False True 54366366.825095795 14315462.052213168 26762117.063946977 1.0 0.2633146720704735 0.49225502138195937 25.696211083692894 -10.114540269517395 5.142697293484029 1.0000173895852518 0.3777848467262851 0.9078223463796362 0.0934645062280056 1.8635449582151198e-05 3.2086712572903783e-06 0.09049914354496166 0.030165539673059724 7.681742241974515e-11 10.114540269517395 -0.6222325428589667 IFSFLLNTLQENVNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFSFLLNTLQENVNK 15 0 Q9HAV4 Q9HAV4 XPO5 Exportin-5 0 47353000.0 21925000.0 13871000.0 11557000.0 False True 28382344.706362154 13099066.656411031 9453744.58483392 1.0 0.4615216534057089 0.33308539807547255 24.75849044164779 -13.999999999999972 0.20134131176789546 4.0087181724439045 0.2507667987428313 0.9994870362912114 0.006543473164564822 12.557755180162832 0.1422733093078284 14.887647397473232 0.080971172713511 1.0000000000000655e-14 13.999999999999972 -3.757951373701073 IFSGSSHQDLSQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFSGSSHQDLSQK 13 0 B1ALA9;P60891;A0A2R8Y7H4;B1ALA7 B1ALA9 PRPS1 Ribose-phosphate pyrophosphokinase 1 0 8269960.0 860560.0 3161100.0 4248300.0 False True 1128202.4936748936 2689476.2018712903 3808726.6685711434 1.0 2.3838594728778344 3.3759247031665205 20.10559460018337 -7.919865871559654 0.1885156844107913 1.50246127580265e-10 4.825828732785929 0.9998858656647642 0.010409372190555145 0.11750442765274646 0.0310515304367901 0.285079787496229 0.39308368494466395 1.2026358018909874e-08 7.919865871559654 4.825828732635683 IFSGSSHQDLSQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFSGSSHQDLSQK 13 0 B1ALA9;P60891;A0A2R8Y7H4;B1ALA7 B1ALA9 PRPS1 Ribose-phosphate pyrophosphokinase 1 0 10666450.0 860560.0 4158210.0 5647680.0 False True 1178732.287759564 3974486.532838359 4313814.301620697 1.0 3.3718313938720827 3.6597065732542506 20.16880466170626 -10.115032687626647 0.4780623977555536 3.812343094358896e-19 3.658019800111082 0.9992580313646099 0.032462303473606985 1.4237906975137935 0.2198820950528112 2.040467011233735 0.060846336598896204 7.673037352733411e-11 10.115032687626647 3.658019800111082 IFSGSSHQDLSQK(ub)IADR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFSGSSHQDLSQKIADR 17 1 B1ALA9;P60891;A0A2R8Y7H4;B1ALA7 B1ALA9 PRPS1 Ribose-phosphate pyrophosphokinase 1 1 6751100.0 1698900.0 1579400.0 3472800.0 True False 1644969.3494308435 2210062.656462194 2563169.498233182 1.0 1.3435281680031739 1.5581867827020814 20.649629271925367 -9.548772080621045 0.08546960032857938 6.859973726629177e-16 2.3311322321339607 0.9999695695308267 0.0012681714849076733 1.0395259774254004 0.03478687544328601 0.5864476084182754 0.35651497095147333 2.826362871641336e-10 9.548772080621045 2.33113223213396 IFSGSSHQDLSQK(ub)IADR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFSGSSHQDLSQKIADR 17 1 B1ALA9;P60891;A0A2R8Y7H4;B1ALA7 B1ALA9 PRPS1 Ribose-phosphate pyrophosphokinase 1 1 14213600.0 4676500.0 2486400.0 7050700.0 True False 7094592.3979454115 2042682.4936681332 5657126.054568403 1.0 0.2879210501592301 0.7973856336280436 22.75828836955717 -9.936163971210972 6.4165843307554775 1.0000000682420267 0.5426533418945636 0.5179534546504672 0.20798804525309755 2.0295267257442419e-07 3.413997579254471e-08 0.20138358887712024 0.06712785295627975 1.1583399334623904e-10 9.936163971210972 -0.4573467263474631 IFSGSSHQDLSQK(ub)IADR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFSGSSHQDLSQKIADR 17 1 B1ALA9;P60891;A0A2R8Y7H4;B1ALA7 B1ALA9 PRPS1 Ribose-phosphate pyrophosphokinase 1 1 7130600.0 1698900.0 2710500.0 2721200.0 True False 1412710.624031131 2695897.9985078736 3290190.3385927794 1.0 1.908315795640584 2.3289910068095274 20.430034547359643 -9.796636492715749 0.1964708347692334 1.7281374171470866e-14 2.7303665975967912 0.999463701841508 0.012843468852559546 1.266213191431524 0.08556034968324158 0.9571937394033911 0.2551511389150365 1.5972154675589842e-10 9.796636492715749 2.730366597596774 IFSGSSHQDLSQK(ub)IADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFSGSSHQDLSQKIADR 17 1 B1ALA9;P60891;A0A2R8Y7H4;B1ALA7 B1ALA9 PRPS1 Ribose-phosphate pyrophosphokinase 1 1 11975700.0 4676500.0 3816800.0 3482400.0 True False 6053821.437596477 3604391.7247631545 2848638.932441435 1.0 0.5953911528309284 0.4705521895228575 22.52941469164962 -13.999999999999998 0.16467912965037654 3.0136069008322393 0.3539518405357854 0.9995248500641576 0.004925922870208923 12.044173657719359 0.12838368414296922 7.745173698647614 0.10693029297238521 1.0000000000000041e-14 13.999999999999998 -2.659655060296454 IFSSLHVSGEQLSQLTGVAAILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFSSLHVSGEQLSQLTGVAAILR 23 0 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 0 13739600.0 5863800.0 1823800.0 6052000.0 False True 5677656.87868184 2552052.8509913553 4466799.643891739 1.0 0.4494905038333094 0.7867329321473153 22.436864233747215 -10.376856830452784 6.259431934889922 1.0000480191067507 0.6181117179903232 0.6309592489239229 0.13767864483107503 9.227243688379978e-05 9.186073907425352e-06 0.13332347302568923 0.0444355915465966 4.1989738457635385e-11 10.376856830452784 -0.3819363011164275 IFSSLHVSGEQLSQLTGVAAILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFSSLHVSGEQLSQLTGVAAILR 23 0 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 0 166777000.0 44258000.0 51819000.0 70700000.0 False True 67142621.69320378 42571494.58630504 56726114.011089146 1.0 0.6340457597981187 0.8448599798543613 26.000725534728378 -10.19878816349614 5.397471163362702 1.0000123415160023 0.739452869826199 0.6706872570260635 0.08606454494357785 1.2782162615732981e-05 1.897248251232017e-06 0.08333558294683144 0.027777212438762185 6.327203991459073e-11 10.19878816349614 -0.2605594716898033 IFSSLHVSGEQLSQLTGVAAILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFSSLHVSGEQLSQLTGVAAILR 23 0 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 0 14036600.0 5863800.0 2957500.0 5215300.0 False True 4876009.510385393 2941567.3604822126 6305795.117177319 1.0 0.6032735076125221 1.2932286337314625 22.21726950918149 -6.750753182647564 1.6468613731582553 0.7669361416849565 1.294696077310743 0.6522963349041825 0.1667141741267097 0.29872780661027626 1.5942536491792605 0.07995769096658868 0.1939773261753896 1.7751980712030772e-07 6.750753182647564 0.5277599356257865 IFSSLHVSGEQLSQLTGVAAILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFSSLHVSGEQLSQLTGVAAILR 23 0 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 0 115729000.0 44258000.0 38431000.0 33040000.0 False True 57292853.45560663 36292281.06643594 27027059.01902854 1.0 0.6334521476497416 0.4717352582197788 25.771851856820827 -13.999999999998664 0.11102636203822693 2.765562265733814 0.1794074448826598 0.9997378525062538 0.0035782171795617876 12.006716423536849 0.10127817924662182 4.743051901745349 0.25958553135204343 1.0000000000030758e-14 13.999999999998664 -2.5861548208511542 IFSSVQWLSGVKPVLSTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFSSVQWLSGVKPVLSTK 18 1 Q9C0C9;K7EQ12 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 0 17007300.0 3258600.0 6932000.0 6816700.0 False True 4272056.156327286 5897772.6207243595 6111373.27440363 1.0 1.3805466044703665 1.4305461002314204 22.026499180750953 -12.104868836486066 0.3219668640235146 3.078018385741036e-09 1.4410530336608514 0.9995482288995432 0.004086528617215053 5.62093978701677 0.17386972968572853 3.762814817099768 0.01651061354901128 7.85472823485073e-13 12.104868836486066 1.441053030582833 IFSSVQWLSGVKPVLSTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFSSVQWLSGVKPVLSTK 18 1 Q9C0C9;K7EQ12 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 0 37869100.0 16334000.0 9420100.0 12115000.0 False True 15815486.110779572 13181595.055172522 8941718.057790551 1.0 0.8334612646643953 0.565377377284409 23.91483456397029 -6.964057466072707 0.3738790397765109 1.0197302430269986 0.36971969422129825 0.9998923728254415 0.0018574247890668118 0.07828230902627314 0.015996921300835003 0.0035140884136059015 0.02272180725423771 1.0862818767215762e-07 6.964057466072707 -0.6500105488057003 IFSSVQWLSGVKPVLSTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFSSVQWLSGVKPVLSTK 18 1 Q9C0C9;K7EQ12 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 0 22788000.0 10427000.0 0.0 12361000.0 False True 15818521.31580815 0.0 9917842.931981236 1.0 0.0 0.6269766139310312 23.915111410036438 -10.201473269876294 7.0954995108496695 1.0000014815008864 0.3134883069655157 0.6151731084588408 0.255962130798165 5.998866084333508e-06 6.745363698515669e-07 0.24783480280131923 0.08261142248675477 6.288205558162958e-11 10.201473269876294 -0.6865131745353708 IFSSVQWLSGVKPVLSTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFSSVQWLSGVKPVLSTK 18 1 Q9C0C9;K7EQ12 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 0 32206500.0 3258600.0 9684900.0 19263000.0 False True 4463392.480353857 9256989.094318526 14713476.133938108 1.0 2.0739805282784882 3.2964782278728992 22.089709242273845 -6.96943736980858 0.27128789741198367 0.7008014230809998 4.7064726820715235 0.99997765565056 0.004434786532585496 0.07648570121056317 0.009681612622750049 0.02377622863228181 0.11349883921400512 1.0729083622375997e-07 6.96943736980858 4.005671258990524 IFSSVQWLSGVKPVLSTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFSSVQWLSGVKPVLSTK 18 1 Q9C0C9;K7EQ12 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 0 34285000.0 16334000.0 8716300.0 9234700.0 False True 13582444.718891345 8669343.561849922 11165633.073571485 1.0 0.6382756375067028 0.822063575789239 23.695239839404568 -10.13058753226915 5.272532945088272 1.0000070320988337 0.730169606647787 0.7418687332850531 0.07503111161236672 6.2023859396274626e-06 1.0228468036843976e-06 0.07265045376013017 0.024216187143417747 7.403080429584638e-11 10.13058753226915 -0.2698374254510467 IFSSVQWLSGVKPVLSTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFSSVQWLSGVKPVLSTK 18 1 Q9C0C9;K7EQ12 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 0 38358000.0 10427000.0 15999000.0 11932000.0 False True 13497957.046897994 15108641.585748691 9760498.432658846 1.0 1.1193280237338474 0.7231093119311662 23.686237732128888 -6.825959042116303 1.3459861185871338 1.0639589205171016 0.7133094242598259 0.8975247976783615 0.05312802619368129 0.1858517346992089 0.6599266080260605 0.031004492882992302 0.07136944848776876 1.492935200184347e-07 6.825959042116303 -0.3506494962572757 IFTASNVSSVPLPAENVTITAGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFTASNVSSVPLPAENVTITAGQR 24 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 11418500.0 3664800.0 3437800.0 4315900.0 False True 3548462.930010095 4810531.467890167 3185436.3157753404 1.0 1.3556662596659792 0.8976946860105083 21.758762804234635 -6.699413680963116 1.8330318182501804 1.2209811702947546 0.8990747398190362 0.4147794469055355 0.1501471946409664 0.3967343355941562 2.5912099261524215 0.06535898882179929 0.1682033700999944 1.9979578369424295e-07 6.699413680963116 -0.32190643047571843 IFTASNVSSVPLPAENVTITAGQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFTASNVSSVPLPAENVTITAGQR 24 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 57198100.0 7273100.0 34985000.0 14940000.0 False True 11033824.434833055 28741653.410947353 11987102.45156538 1.0 2.604867748322318 1.0863959747014724 23.395429594474283 -6.633122554794518 2.0694320637611856 2.0548430302990175 1.0925850021459962 0.12899114251862098 0.6878474183717241 0.5507033214973458 4.4985346561461785 0.27149768114977296 0.7617366805195606 2.3274343796618966e-07 6.633122554794518 -0.9622580281530213 IFTASNVSSVPLPAENVTITAGQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFTASNVSSVPLPAENVTITAGQR 24 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 7830300.0 3664800.0 2375000.0 1790500.0 False True 3047443.5781678054 2362205.4035994094 2164885.271663374 1.0 0.775143277638506 0.7103938813413417 21.53916807966891 -13.999999999999998 0.17457832163591575 2.1481893086242563 0.6559749543930744 0.9995056886403486 0.0027592970286754257 12.1394032350774 0.13239116966462566 4.722951420127864 0.05066760437574935 1.0000000000000041e-14 13.999999999999998 -1.4922143542311819 IFTASNVSSVPLPAENVTITAGQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFTASNVSSVPLPAENVTITAGQR 24 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5;Q5VU77 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 22699600.0 7273100.0 8600900.0 6825600.0 False True 9415171.324234566 8122252.354201268 5583410.836570259 1.0 0.8626770639101027 0.5930227549018264 23.166555916566733 -6.960402024668088 0.42973089534941245 1.0107417032280182 0.43462191473874057 0.9997848179027049 0.0024798042282969863 0.07955782882207992 0.020603031370492395 0.0035153227436517808 0.022391052547719153 1.09546366030276e-07 6.960402024668088 -0.5761197884892776 IFTFGTWIYSVNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFTFGTWIYSVNK 13 0 P98170 P98170 XIAP E3 ubiquitin-protein ligase XIAP 0 24616600.0 7735600.0 7123800.0 9757200.0 False True 11735470.74811216 5852502.231496548 7828685.143267317 1.0 0.49870195726388034 0.667095961576717 23.484372378449727 -10.27649073501569 6.354378732186197 1.0000105387569174 0.5828989594202988 0.8910708298021155 0.06874656438508055 1.0264182726451576e-05 1.1687279043194353e-06 0.0665652543943564 0.02218785824769932 5.290652838583252e-11 10.27649073501569 -0.4171115793366186 IFTFGTWIYSVNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFTFGTWIYSVNK 13 0 P98170 P98170 XIAP E3 ubiquitin-protein ligase XIAP 0 24844100.0 7735600.0 8813400.0 8295100.0 False True 10013886.691472532 8322926.542398748 6785476.914913543 1.0 0.8311384778785499 0.6776067199453947 23.255498700542176 -6.972259953345056 0.19687396978065236 1.0951544974574876 0.4093659995523187 0.9999950574013481 0.0002926625362271474 0.07557602025578944 0.006332528133932897 0.005115310278206007 0.01643051166968496 1.0659578854776686e-07 6.972259953345056 -0.6857884979051689 IFTLNLSAPFISQFYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFTLNLSAPFISQFYK 16 0 P55263;A0A5K1VW54;P55263-4;P55263-2;A0A5F9ZHJ1;A0A5F9ZH31;A0A5K1VW94;A0A5F9ZH72;A0A5F9ZGZ8 P55263 ADK Adenosine kinase 0 2716120000.0 1173100000.0 816640000.0 726380000.0 False True 1779678465.097777 670904211.5625578 582810674.6163357 1.0 0.376980575266835 0.3274808826684969 30.72896946668875 -13.999999999999998 0.3590188998712625 9.102083828675035 0.3214367866477207 0.99977150945239 0.004625905840006428 21.591468361015956 0.1935678552928879 133.97569521441397 0.014329851585508636 1.0000000000000041e-14 13.999999999999998 -8.780647042027313 IFTLNLSAPFISQFYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFTLNLSAPFISQFYK 16 0 P55263;A0A5K1VW54;P55263-4;P55263-2;A0A5F9ZHJ1;A0A5F9ZH31;A0A5K1VW94;A0A5F9ZH72;A0A5F9ZGZ8 P55263 ADK Adenosine kinase 0 3069080000.0 1173100000.0 786380000.0 1109600000.0 False True 1518601075.258082 742617261.7164236 907664185.4574468 1.0 0.48901404971691986 0.5976975785449065 30.5000957887812 -10.474795945192843 5.8912050125513185 1.0003676996124753 0.5433558141309844 0.9592466639793304 0.044369864845606004 0.00021444991814515476 1.911831478540567e-05 0.042994453134526545 0.01432031230170876 3.351228608405985e-11 10.474795945192843 -0.45701188548149085 IFTNK(ub)CER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFTNKCER 8 1 A0A087X0D9;Q8WV99;B8ZZ56;E7EV05;E9PFU9;B4DEN4;Q8WV99-2 A0A087X0D9 ZFAND2B AN1-type zinc finger protein 2B 1 7063200.0 2152200.0 3620600.0 1290400.0 True False 2821555.0419344488 3080420.5929882657 1156881.7863908391 1.0 1.0917457030632085 0.4100156719245444 21.42805906278428 -6.872950687054406 1.1183067432255702 1.052945414717003 0.3677747980235776 0.9675434041309624 0.05442132844916535 0.13406027610195345 0.31155002646984353 0.037693932591826684 0.08973261391558983 1.3398288126707977e-07 6.872950687054406 -0.6851706166934254 down IFTNK(ub)CER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFTNKCER 8 1 A0A087X0D9;Q8WV99;B8ZZ56;E7EV05;E9PFU9;B4DEN4;Q8WV99-2 A0A087X0D9 ZFAND2B AN1-type zinc finger protein 2B 1 5021200.0 3038800.0 1011600.0 970800.0 True False 2526896.841665669 1006150.310013122 1173789.7915279535 1.0 0.39817625057851286 0.464518286688039 21.268935338056735 -10.255497350436638 5.544464665756816 1.0000423621989432 0.43134726863600853 0.9898950592022482 0.02708402282767842 1.4183572547418755e-05 1.9045533703318285e-06 0.02622593805060244 0.008741330779981142 5.5526800471331573e-11 10.255497350436638 -0.5686950935629347 IFTNK(ub)CER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFTNKCER 8 1 A0A087X0D9;Q8WV99;B8ZZ56;E7EV05;E9PFU9;B4DEN4;Q8WV99-2 A0A087X0D9 ZFAND2B AN1-type zinc finger protein 2B 1 4574400.0 1511100.0 2007700.0 1055600.0 True False 1956148.7382341558 1895969.730089858 863491.6313706572 1.0 0.9692359752773082 0.44142432244193447 20.899584640920313 -6.918869489015346 0.8330704261180645 1.0121272604872393 0.35848508897438636 0.9938609996131514 0.020087181882170454 0.09884168790532219 0.10909558049534564 0.017204313879885316 0.05099094470345396 1.205398123330409e-07 6.918869489015346 -0.653642171512853 down IFTNTK(ub)VKPQFQEILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFTNTKVKPQFQEILR 16 2 Q9P260;A0A075B768;A0A075B785;A0A2R8Y566;Q9P260-2 Q9P260 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 1 6743600.0 1095000.0 2152600.0 3496000.0 True False 1060239.8243726974 3012144.405660702 2580292.7222481035 1.0 2.84100289049496 2.433687796791412 20.01595920609253 -10.135015933969326 5.065595674022631 0.9999320090422767 2.637345343646118 0.9556454195048767 0.16628569069483368 58075252.515460126 6.211884698695559 46059.55866012689 0.0569240148633737 7.327976467981502e-11 10.135015933969326 1.6374133346038413 IFTNTK(ub)VKPQFQEILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFTNTKVKPQFQEILR 16 2 Q9P260;A0A075B768;A0A075B785;A0A2R8Y566;Q9P260-2 Q9P260 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 1 16645500.0 2537700.0 7848500.0 6259300.0 True False 3849876.430720855 6447873.854389613 5022146.611451351 1.0 1.6748261847932364 1.3044955342919926 21.876380709768803 -10.127499812510028 4.370705248103835 0.9999364870213387 1.489660859327779 0.6997936867513188 0.15118685522559294 79769898.5370925 9.205465217383066 60401.86703814176 0.055328723599521644 7.455901939076593e-11 10.127499812510028 0.48972437230644017 IFTNTK(ub)VKPQFQEILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFTNTKVKPQFQEILR 16 2 Q9P260;A0A075B768;A0A075B785;A0A2R8Y566;Q9P260-2 Q9P260 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 1 6766200.0 1095000.0 2844000.0 2827200.0 True False 910541.0167249927 2828678.807510197 3418354.4485041588 1.0 3.106591307313433 3.7542014974780558 19.796364481526805 -9.613486625014206 0.3335276473004054 1.4452913252832776e-21 3.933949488421062 0.9985913742459241 0.04413008587468146 0.971695196025301 0.1385703665452758 1.2655590956113636 0.2009191217974202 2.435080792084891e-10 9.613486625014206 3.933949488421062 IFTNTK(ub)VKPQFQEILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFTNTKVKPQFQEILR 16 2 Q9P260;A0A075B768;A0A075B785;A0A2R8Y566;Q9P260-2 Q9P260 KIAA1468 LisH domain and HEAT repeat-containing protein KIAA1468 1 16451400.0 2537700.0 4448400.0 9465300.0 True False 3285102.675545512 4200842.629542135 7742712.522179498 1.0 1.278755352401446 2.356916445813607 21.647507031861252 -6.945647429871723 0.6047447127318375 0.9879716239618892 2.7033431910724994 0.9988139268919268 0.02015141493679031 0.08528203501470324 0.04356867689382895 0.02058667111522134 0.09074872360650962 1.1333200448390865e-07 6.945647429871723 1.7153715671106102 up IFTSIGEDYDER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFTSIGEDYDER 12 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2;D6RBK0 P35232 PHB Prohibitin 0 25587900.0 4952900.0 10784000.0 9851000.0 False True 6493299.863951825 9175069.235702764 8831713.017464481 1.0 1.413005625481589 1.3601270852274328 22.63052040463212 -10.117292721127978 4.563574159254135 0.999964492378455 1.3865663553258454 0.9861605217112491 0.021587573699215934 7.955644835795528e-06 1.53878601470526e-06 0.020904033573842573 0.006967359454738481 7.63321120033566e-11 10.117292721127978 0.3866018629473904 IFTSIGEDYDER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFTSIGEDYDER 12 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2;D6RBK0 P35232 PHB Prohibitin 0 23212300.0 7259600.0 2703700.0 13249000.0 False True 7029147.9717041375 3783301.509609239 9778689.438519761 1.0 0.538230454791809 1.3911628376417615 22.744918394967215 -6.759666245227078 1.6136637366656843 0.7316674681464006 1.3942342109661592 0.6896254487974727 0.19421263506709235 0.28347999440943833 1.4547506696049823 0.09496323745467361 0.22829259557355128 1.7391368398354996e-07 6.759666245227078 0.6625667428197586 IFTSIGEDYDER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFTSIGEDYDER 12 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2;D6RBK0 P35232 PHB Prohibitin 0 25640500.0 4952900.0 9604600.0 11083000.0 False True 6784120.9770897385 9180237.01383511 8465423.661549898 1.0 1.3531947683181293 1.2478291130329175 22.69373046615501 -10.106581278816938 4.354258252273126 0.9999619712055108 1.3005119406988237 0.915582331216988 0.04301534872798573 6383422.567189178 7408217.947326085 1886.9284138059095 0.014725297956145203 7.823817675269753e-11 10.106581278816938 0.3005499694933129 IFTSIGEDYDER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFTSIGEDYDER 12 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2;D6RBK0 P35232 PHB Prohibitin 0 14524900.0 7259600.0 4681100.0 2584200.0 False True 6036679.054809822 4655881.985174402 3124544.2720092097 1.0 0.7712654495793929 0.5175932401971376 22.52532367040149 -6.969790505371747 0.26314267382767587 1.0685408624312547 0.2127607163936931 0.9999807012320417 0.0008655381830910389 0.07637077347406729 0.009273144753489613 0.005189909647944459 0.023823349521377702 1.0720363085573082e-07 6.969790505371747 -0.8557801460375616 IFVEFSIASETHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFVEFSIASETHK 13 0 A0A0J9YYL3;Q9UHX1-2;Q9UHX1-6;Q9UHX1-4;A0A0J9YVP6;Q9UHX1;Q9UHX1-5;Q9UHX1-3;A0A0J9YXX5;A0A0J9YXJ8 A0A0J9YYL3 PUF60 Poly(U)-binding-splicing factor PUF60 0 69984000.0 18332000.0 27376000.0 24276000.0 False True 27810984.24871916 22490538.91033573 19477837.959451225 1.0 0.8086926629132709 0.7003649272264889 24.729151467710196 -13.99999939026588 0.06580632785244983 2.148380427173353 0.27084900305025633 0.9999379242095043 0.0009760049679959745 12.404022207254359 0.06779812504362759 2.2475404041534808 0.3983883147723386 1.0000014039656791e-14 13.99999939026588 -1.8775314241230967 IFVEFTSVFDCQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFVEFTSVFDCQK 13 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 200622000.0 56063000.0 83920000.0 60639000.0 False True 85051669.75430621 68943820.33004728 48653675.07098208 1.0 0.8106110148008777 0.5720484408069921 26.341836223705258 -6.967996586805121 0.30223235954488614 1.04029228596324 0.33486817699106375 0.9999622675057733 0.0010755337934164107 0.07695826803822746 0.011344579998612372 0.003914661153234662 0.02134555481825647 1.0764736737879661e-07 6.967996586805121 -0.7054241089721762 IFVGGIK(ub)EDTEEYNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFVGGIKEDTEEYNLR 16 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 21840500.0 8568800.0 7491100.0 5780600.0 True False 7125336.862203759 7450743.957433065 6989296.733525445 1.0 1.045669012079334 0.9809075512766369 22.764526790919465 -6.717215324052869 1.7692791788903435 1.0278665603716495 0.9810235197967069 0.4993790015116948 0.019224519757271005 0.3607517137292206 2.2054210896106383 0.008632587969180134 0.02174279288747239 1.9177176967432117e-07 6.717215324052869 -0.046843040574942596 IFVGGIPHNCGETELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFVGGIPHNCGETELR 16 0 K7EQ02;K7EQ55;K7EK33;Q96EP5-2;Q96EP5 K7EQ02 DAZAP1 DAZ-associated protein 1 0 12852000.0 1491700.0 5453900.0 5906400.0 False True 1955633.1456433465 4640199.37913569 5295262.386189441 1.0 2.3727350855516405 2.7076971966781906 20.899204331945903 -10.212374923298924 0.3211951589456288 9.543016643649484e-13 2.7985864891302192 0.9989574769675507 0.02385544223164931 1.6492390385893916 0.14859863656485942 1.552730358363851 0.10989376724587797 6.132323774901348e-11 10.212374923298924 2.798586489129265 IFVGGIPHNCGETELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFVGGIPHNCGETELR 16 0 K7EQ02;K7EQ55;K7EK33;Q96EP5-2;Q96EP5 K7EQ02 DAZAP1 DAZ-associated protein 1 0 17140100.0 1491700.0 6780800.0 8867600.0 False True 2043221.8016767462 6481201.834892977 6773255.513954693 1.0 3.1720500581847033 3.3149878825667876 20.962414393468794 -10.3531187202363 0.5592736372873416 6.113338535821745e-16 3.302582208819731 0.9996823726943886 0.018877412003379633 1.6955964607323468 0.267356163764634 2.5925922334655196 0.02625379340568515 4.4348739411709003e-11 10.3531187202363 3.3025822088197305 IFVGGLNPEATEEK(ub)IR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFVGGLNPEATEEKIR 16 1 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 1 16229200.0 5536000.0 4606400.0 6086800.0 True False 5360262.71025319 6445759.542058665 4492484.479914115 1.0 1.202508140082224 0.8381090112096229 22.353872279240715 -6.755867601885119 1.6280625206405452 1.1182299279109351 0.8370441976726916 0.6738706226021549 0.08513224629980004 0.2899092404644687 1.5134979865006128 0.04127775205281287 0.0996044483187538 1.754415267723085e-07 6.755867601885119 -0.28118573023824356 IFVGGLNPEATEEK(ub)IR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFVGGLNPEATEEKIR 16 1 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 1 12074100.0 3892200.0 5066700.0 3115200.0 True False 5331251.52275004 4842836.4406636795 2379453.919557907 1.0 0.9083864117079925 0.4463218269489008 22.346042817827996 -6.939611704583404 0.6631669280843365 1.0052227409195325 0.323128612840422 0.99811258540597 0.010527296465841749 0.08794424787793535 0.05541990003774992 0.010217624996794985 0.03983750451679141 1.1491806254495286e-07 6.939611704583404 -0.6820941280791104 down IFVGGLNPEATEEK(ub)IR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFVGGLNPEATEEKIR 16 1 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 1 13518500.0 5536000.0 5974800.0 2007700.0 True False 4603429.286383152 5942612.566495052 2427500.7874440374 1.0 1.290909927534496 0.5273244436760512 22.13427755467499 -6.803464649440158 1.4418087195182463 1.1598094181432133 0.5158701228082874 0.842075782877202 0.12504595193753584 0.2158508044897762 0.8854864320881382 0.06821903715229813 0.15832354949533373 1.5722997687954385e-07 6.803464649440158 -0.6439392953349259 IFVGGLPYHTTDASLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFVGGLPYHTTDASLR 16 0 F6VZ39;Q9H0Z9;Q9H0Z9-2;Q9BX46;E9PSF1 F6VZ39 RBM38;RBM24 RNA-binding protein 38;RNA-binding protein 24 0 10057200.0 3264100.0 3644600.0 3148500.0 False True 4279266.709589368 3100839.8865395263 2822723.4225446065 1.0 0.7246194493067899 0.6596278320814154 22.028932168503097 -13.999999999557822 0.20283899307687975 2.54761633786715 0.6185806607684523 0.9994872705251596 0.0033408138881225345 12.588517441982153 0.1427945353402873 7.7387461669503335 0.040524239825824336 1.0000000010181522e-14 13.999999999557822 -1.9290356770986976 IFVGGLSPDTPEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFVGGLSPDTPEEK 14 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 89282600.0 7378600.0 36408000.0 45496000.0 False True 9673416.054464038 30976068.317272484 40788510.34844824 1.0 3.2021850546765025 4.216557017582777 23.20559401999236 -9.038151253709588 0.2870368611419592 1.7649449332467382e-20 4.723305122163317 0.9987754067080249 0.046985566819216625 0.49383321758843257 0.10021245394781131 0.8853633092572584 0.36438097844340633 9.159014494151545e-10 9.038151253709588 4.723305122163317 IFVGGLSPDTPEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFVGGLSPDTPEEK 14 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 53392200.0 16869000.0 7741200.0 28782000.0 False True 16333502.828623755 10832301.52982469 21243130.758508265 1.0 0.6631952523277219 1.3005863458315017 23.96133088386595 -6.763115835667786 1.6005443639061983 0.8051279298277284 1.3032976958984932 0.7036467518449796 0.1417322875255899 0.2777060257514859 1.402747466691423 0.06984341586405166 0.16734569323596793 1.7253776353330644e-07 6.763115835667786 0.4981697660707648 IFVGGLSPDTPEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFVGGLSPDTPEEK 14 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 185476800.0 2986000.0 179780000.0 2710800.0 False True 4529980.305840898 147696854.37244886 2175009.1918141497 1.0 32.60430386021997 0.4801365668212113 22.111073347470423 -3.0455082671726634 1.04033803506477e-17 9.52289139495138 20.453105026909288 0.0 15.453978648046126 0.0 0.6045175009543753 915324900.1290002 915324872.1766967 0.0009005166204714879 3.0455082671726634 10.930213631957908 IFVGGLSPDTPEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFVGGLSPDTPEEK 14 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 75073600.0 7378600.0 33815000.0 33880000.0 False True 10106667.819167426 32320941.488748588 25878241.780502662 1.0 3.197981972599466 2.56051175753736 23.268804081515253 -10.122616892464476 5.265290361722656 0.9999548872905298 2.8792468650698737 0.9205555789258145 0.26024612552584936 0.00013782394816052045 2.2966680667442823e-05 0.25198819922230464 0.08399407583898104 7.54020420282625e-11 10.122616892464476 1.879291977779344 IFVGGLSPDTPEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFVGGLSPDTPEEK 14 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 21958900.0 16869000.0 2553800.0 2536100.0 False True 14027320.92340994 2540042.1725103874 3066386.784398483 1.0 0.1810782106133579 0.21860102874534268 23.741736159300228 -10.691764818980912 6.719491948901089 1.0067919297731005 0.1998396196794791 0.9983534214813773 0.015318626355769228 0.0015546914674837479 7.131639450824399e-05 0.014794433385187945 0.004944065396889018 2.033457879708311e-11 10.691764818980912 -0.8069523100936213 IFVGGLSPDTPEEK(ub)IR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFVGGLSPDTPEEKIR 16 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 130794800.0 50293800.0 48516000.0 31985000.0 True False 65935658.845851995 41277601.91388683 28675499.021784764 1.0 0.6260285047031664 0.4349012283144682 25.97455556839104 -12.424293275374785 0.10101604460046365 2.392175765426417 2.2280537293984067e-11 0.999839203189953 0.0029760160797948007 6.7534183072165 0.07837658376749311 2.2990761684718635 0.33829961587632784 3.7644949998077344e-13 12.424293275374785 -2.3921757654041365 IFVGGLSPDTPEEK(ub)IR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFVGGLSPDTPEEKIR 16 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 172749000.0 65932000.0 59906000.0 46911000.0 True False 63839024.74935209 83826778.20566297 34623601.80016611 1.0 1.3130961592033676 0.5423579375798266 25.92793527629779 -6.796444309251587 1.4705738418870453 1.1735377887790421 0.5326526739076682 0.821494898213914 0.13371730589037487 0.22588248287579177 0.964757041396543 0.07154875189491641 0.16675556885916099 1.5979224218073323e-07 6.796444309251587 -0.6408851148713739 IFVGGLSPDTPEEK(ub)IR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFVGGLSPDTPEEKIR 16 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 280730000.0 104870000.0 114440000.0 61420000.0 True False 159095457.02395707 94017287.87619892 49280310.07865766 1.0 0.590948916046305 0.3097530941517512 27.245317399151368 -8.171812927975147 0.2155818547568452 1.2450340885288151 1.7435691180009049e-12 0.9997277326331454 0.004676228210716867 0.08721944583644514 0.04414937963100447 0.09576342374912857 0.10910382684498861 6.732666029208109e-09 8.171812927975147 -1.2450340885270716 down IFVGGLSPDTPEEK(ub)IR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFVGGLSPDTPEEKIR 16 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 135356800.0 50293800.0 50360000.0 34703000.0 True False 68888776.99884027 48134928.68175001 26506866.130719684 1.0 0.6987339705937927 0.3847777139542762 26.03776562991393 -7.054477476750127 0.25296980797015445 1.1003954354109253 2.3675827219694897e-11 0.9999840792250251 0.0010022178297946606 0.0729178156279742 0.009019465520720582 0.00737194938918477 0.02938246853910864 8.821095486506702e-08 7.054477476750127 -1.1003954353872496 down IFVGGLSPDTPEEK(ub)IR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFVGGLSPDTPEEKIR 16 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 170200600.0 65932000.0 76834600.0 27434000.0 True False 54825379.28284209 76420676.759326 33170322.55951576 1.0 1.3938923498381026 0.6050176577601278 25.708340551732068 -6.770941635515098 1.5707790907977137 1.2256553229961367 0.6004147206627545 0.7341673378404951 0.16604916908537468 0.26491324910546077 1.2900862184397592 0.08331642422233669 0.1981625015892574 1.6945655164377645e-07 6.770941635515098 -0.6252406023333822 IFVGGLSPDTPEEK(ub)IR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFVGGLSPDTPEEKIR 16 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 270063800.0 104870000.0 127646800.0 37547000.0 True False 135756282.2967481 120543143.36944468 30713831.26475374 1.0 0.8879378643115079 0.22624243051689297 27.016443721243817 -6.936174276106748 0.6942387741442015 1.0081422190441052 0.06624212761740028 0.9976186923885568 0.016660760400255863 0.08955602072799136 0.0628865284283697 0.015781511350194195 0.05797526361152054 1.1583124488150556e-07 6.936174276106748 -0.9419000914267048 down IFVGNVSAACTSQELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFVGNVSAACTSQELR 16 0 Q96PK6;Q96PK6-2;A0A0A6YYI9;F8WDX3;A0A0A0MSL8;B8ZZ74;Q96PK6-3;Q96PK6-4 Q96PK6 RBM14;RBM14-RBM4 RNA-binding protein 14 0 29998200.0 8045900.0 9361300.0 12591000.0 False True 10548252.816606436 7964630.530061606 11288204.101400398 1.0 0.7550663288542578 1.0701491799313942 23.330500718920028 -6.699239736859936 1.833813810134238 0.8477923551921155 1.069192014358436 0.41390507951769495 0.10340389235362253 0.3970837468403033 2.5956215750884573 0.04499624324410709 0.11581715994653813 1.9987582214857786e-07 6.699239736859936 0.22139965916632043 IFVGNVSAACTSQELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFVGNVSAACTSQELR 16 0 Q96PK6;Q96PK6-2;A0A0A6YYI9;F8WDX3;A0A0A0MSL8;B8ZZ74;Q96PK6-3;Q96PK6-4 Q96PK6 RBM14;RBM14-RBM4 RNA-binding protein 14 0 9510400.0 5256600.0 1378400.0 2875400.0 False True 5089732.110317368 1928802.3082610383 2122246.479849027 1.0 0.37895949461685297 0.41696624377283686 22.279158293741567 -10.127353143885841 5.70452960556887 1.0000063326173638 0.39796286919479407 0.9970198370084692 0.015516190369199188 1.24966766124589e-06 1.9116054998062985e-07 0.01502364455686611 0.005007828908014831 7.458420349050734e-11 10.127353143885841 -0.6020434634225698 IFVGNVSAACTSQELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFVGNVSAACTSQELR 16 0 Q96PK6;Q96PK6-2;A0A0A6YYI9;F8WDX3;A0A0A0MSL8;B8ZZ74;Q96PK6-3;Q96PK6-4 Q96PK6 RBM14;RBM14-RBM4 RNA-binding protein 14 0 40157000.0 4431400.0 29225000.0 6500600.0 False True 6722757.778735222 24009570.41403279 5215753.560685803 1.0 3.571387100986673 0.7758354134346133 22.680621739462907 -6.664888884212035 1.9557636347742984 2.6484609648904263 0.7874081735184278 0.2565598655418142 1.093570768482556 0.4729193605978508 3.4823898351108395 0.4509793045944658 1.2128716703998008 2.163271933746973e-07 6.664888884212035 -1.8610527913719985 IFVGNVSAACTSQELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFVGNVSAACTSQELR 16 0 Q96PK6;Q96PK6-2;A0A0A6YYI9;F8WDX3;A0A0A0MSL8;B8ZZ74;Q96PK6-3;Q96PK6-4 Q96PK6 RBM14;RBM14-RBM4 RNA-binding protein 14 0 26680900.0 8045900.0 8706800.0 9928200.0 False True 11020686.662271874 8322104.7864626935 7583363.637697347 1.0 0.755134869676725 0.6881026446072703 23.39371078044292 -13.999999999999998 0.18179335281154088 2.277574102499863 0.6358298156883472 0.9994960834986264 0.0030092308052491012 12.22847540297415 0.13517790246257758 5.520710848535455 0.0492962299444844 1.0000000000000041e-14 13.999999999999998 -1.6417442868115155 IFVGNVSAACTSQELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFVGNVSAACTSQELR 16 0 Q96PK6;Q96PK6-2;A0A0A6YYI9;F8WDX3;A0A0A0MSL8;B8ZZ74;Q96PK6-3;Q96PK6-4 Q96PK6 RBM14;RBM14-RBM4 RNA-binding protein 14 0 18035200.0 4431400.0 10373000.0 3230800.0 False True 5736534.65595317 9795733.43140016 2642827.550807424 1.0 1.707604681030646 0.4607010519957013 22.451748061555357 -6.752743063764458 1.6395375896828865 1.414698535322177 0.4576702707432236 0.660757522989082 0.29739053769621027 0.29528163671362634 1.5624618610433159 0.14323409660558123 0.3467593726243666 1.767082948775017e-07 6.752743063764458 -0.9570282645789534 IFVNGCWVGIHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFVNGCWVGIHK 12 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 9292700.0 2731700.0 5183400.0 1377600.0 False True 3581285.1538204285 4410056.924734949 1235059.1668723044 1.0 1.2314174200930097 0.3448647940124994 21.772045964727674 -6.837353924899338 1.2945294542674028 1.1231856343433972 0.3171826869121528 0.9198235055718141 0.10631319628757678 0.17191255053319773 0.560746385763081 0.0644216506010319 0.14833439185384478 1.4542734487371507e-07 6.837353924899338 -0.8060029474312445 down IFVNGCWVGIHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IFVNGCWVGIHK 12 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 6856600.0 1170700.0 3200500.0 2485400.0 False True 1776037.4896342773 2629345.7693793625 1994159.6006104816 1.0 1.480456231766143 1.1228139114457094 20.76023060458123 -10.728452628663083 11.344123414687425 0.9997493804517237 1.3016350716059262 0.48676587590369025 0.1460068658683463 0.0009261972096380538 2.2170535726687427e-05 0.14148193825867497 0.047123513328337086 1.8687335011131323e-11 10.728452628663083 0.3018856911542025 IFVNGCWVGIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFVNGCWVGIHK 12 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 10644300.0 2731700.0 3327900.0 4584700.0 False True 3741683.311416754 3180862.3741063513 3501888.2848604033 1.0 0.850115338302628 0.9359125274379368 21.835256026250565 -10.119608363216528 4.562654686589638 1.000010289729168 0.8930139328700395 0.6746092306503806 0.03502655580041105 3.6665992444187273e-06 7.074537152978017e-07 0.033917578315854645 0.011304772272854523 7.592619513849026e-11 10.119608363216528 -0.10699635685912856 IFVNGCWVGIHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IFVNGCWVGIHK 12 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 4103100.0 1170700.0 2932400.0 0.0 False True 1515494.2279470114 2769209.362213232 0.0 1.0 1.827264869206784 0.0 20.53135692667368 -6.792830126278608 1.545562851197216 1.4657273056670497 3.477370247528653e-21 0.7796129391624922 0.35072344329589644 0.23902594765580523 1.1374282948724126 0.18027253231381318 0.41056789662950854 1.6112757603506109e-07 6.792830126278608 -1.4657273056670497 IFYPEIEEVQALDDTER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFYPEIEEVQALDDTER 17 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YKC5 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 40450500.0 14391000.0 5689500.0 20370000.0 False True 13934165.582235137 7961347.020350546 15034485.913098924 1.0 0.5713544146841902 1.0789656419948532 23.732123276526636 -6.682900984643109 1.8918835938985585 0.7294902147555445 1.077063380298573 0.33726210668120915 0.18155781525701117 0.43214150165441234 2.9929779500732843 0.07693987710670709 0.20215022405066743 2.0753866335846353e-07 6.682900984643109 0.3475731655430284 IFYQFLYNNNTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IFYQFLYNNNTR 12 0 J3QQW9;Q15022 J3QQW9 SUZ12 Polycomb protein SUZ12 0 16018000.0 5028500.0 6460400.0 4529100.0 False True 6592412.196063274 5496533.502441962 4060472.178194947 1.0 0.8337666606654653 0.6159311732084501 22.652375020374546 -6.967405250023645 0.31404402654874997 1.0319963360459485 0.410736358750893 0.9999544862281506 0.0010609651678247362 0.07715398432712707 0.01202955845390259 0.0033854532585150337 0.01926535966731728 1.0779404021737805e-07 6.967405250023645 -0.6212599772950556 IFYQFLYNNNTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IFYQFLYNNNTR 12 0 J3QQW9;Q15022 J3QQW9 SUZ12 Polycomb protein SUZ12 0 22463700.0 10144000.0 4110200.0 8209500.0 False True 9821984.272544859 5751424.294409839 6059185.670279115 1.0 0.5855664328934682 0.6169003637295777 23.227583081743397 -10.340605883069367 6.862569990808993 1.000011900904809 0.601233398311523 0.9953905715180698 0.012792023697354613 2.3292823217937317e-06 2.2379977779383993e-07 0.012386192931205183 0.004128607895345417 4.5645095171268454e-11 10.340605883069367 -0.39877850259328596 IFYQFLYNNNTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFYQFLYNNNTR 12 0 J3QQW9;Q15022 J3QQW9 SUZ12 Polycomb protein SUZ12 0 10437400.0 5028500.0 5408900.0 0.0 False True 6887672.340102928 5169916.913159606 0.0 1.0 0.7506043635464732 0.0 22.715585081897437 -7.333153988191628 0.7980073198190546 0.9892340785503488 5.978635776067652e-23 0.9879677619102227 0.046618626743751654 0.10727750358510946 0.13767767043222773 0.03993471056432615 0.07095151206079563 4.6435060081289895e-08 7.333153988191628 -0.9892340785503488 down IFYQFLYNNNTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IFYQFLYNNNTR 12 0 J3QQW9;Q15022 J3QQW9 SUZ12 Polycomb protein SUZ12 0 17239400.0 10144000.0 0.0 7095400.0 False True 8435185.455395713 0.0 8579015.3345771 1.0 0.0 1.0170511816179908 23.007988357177673 -12.074330691031339 18.185940087729556 0.8837698300699868 0.5576730317281068 0.0 0.4891082503814724 0.0 0.0 0.0 0.14066129071308875 8.426928497908822e-13 12.074330691031339 -0.32609679834188 IFYVNYLSELSEHVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IFYVNYLSELSEHVK 15 0 Q07960;H0YE29 Q07960 ARHGAP1 Rho GTPase-activating protein 1 0 6197570.0 793670.0 1758400.0 3645500.0 False True 1087111.2471252833 1680708.0737487948 2784507.981429235 1.0 1.546031354374446 2.5613827368564945 20.052068152250293 -6.961443904366653 0.4145828352591091 0.9524145085445019 3.1929630266009386 0.9998200580518414 0.00867846548290245 0.07918931192907434 0.01925489921831075 0.01309602418167831 0.08465281224663083 1.0928387745596427e-07 6.961443904366653 2.2405485180564364 IGAEVYHHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGAEVYHHLK 10 0 P13929;P13929-3;P13929-2;E5RGZ4;K7EPM1;K7EKN2 P13929 ENO3 Beta-enolase;Enolase 0 3071540.0 878670.0 863270.0 1329600.0 False True 1151944.8790523855 734473.4810001042 1192025.7464237928 1.0 0.6375942932306777 1.034794084422146 20.135640254315913 -6.6666058204889564 1.9492110529687514 0.7680099877233197 1.0331741261420715 0.26418822124980756 0.1540627860862601 0.4689542220397689 3.4316494751782733 0.06370209775398099 0.17096495766925776 2.1547365550219504e-07 6.6666058204889564 0.26516413841875175 IGAEVYHHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGAEVYHHLK 10 0 P13929;P13929-3;P13929-2;E5RGZ4;K7EPM1;K7EKN2 P13929 ENO3 Beta-enolase;Enolase 0 3109830.0 799310.0 350320.0 1960200.0 False True 773936.3415701727 490204.6028946665 1446764.8152605065 1.0 0.6333913741537613 1.8693589350324216 19.561855379982266 -6.827257680891477 1.340299524831869 0.8037121193989184 1.9007506366535556 0.9002398876961851 0.1637071450359585 0.18422299154519484 0.64821654687323 0.09593157769433218 0.22078563155189568 1.4884776539644533e-07 6.827257680891477 1.0970385172546373 IGAEVYHHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGAEVYHHLK 10 0 P13929;P13929-3;P13929-2;E5RGZ4;K7EPM1;K7EKN2 P13929 ENO3 Beta-enolase;Enolase 0 3077880.0 878670.0 729910.0 1469300.0 False True 1203538.0441639144 697660.1627104091 1122281.6011833693 1.0 0.5796743743111723 0.9324853556773163 20.198850315838804 -10.048027571694636 7.138637589959474 1.0000000390356567 0.7560798649942443 0.389241627657422 0.14403447999960634 8.955285645722139e-08 1.1935507304331432e-08 0.13946080843887862 0.04648692852651002 8.953079240714819e-11 10.048027571694636 -0.24392017404141242 IGAEVYHNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGAEVYHNLK 10 0 P06733;A0A2R8Y6G6;K7EM90;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 0 989500260.0 363561000.0 301259950.0 324679310.0 False True 476631991.7297327 256313139.76208732 291084609.54506004 1.0 0.5377589927019124 0.6107114390049491 28.828300548144608 -10.687948239918283 6.744648431887997 1.0033457256225775 0.5742352158534588 0.9784551998440285 0.02978271148837148 0.0015060631625264623 6.968030832286974e-05 0.02898526820234688 0.009612328799946916 2.0514066549894184e-11 10.687948239918283 -0.4291105097691187 IGAEVYHNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGAEVYHNLK 10 0 P06733;A0A2R8Y6G6;K7EM90;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 0 696460300.0 168906000.0 84315300.0 443239000.0 False True 163544171.48447 117982838.98848085 327141409.0150245 1.0 0.7214126796300068 2.0003244753120994 27.2851051035377 -6.849656211030924 1.2368352544108072 0.8513853254753826 2.0510871998853837 0.939791698978966 0.13474165513123837 0.15783649095481284 0.46482221841911436 0.08525597492942463 0.1972342791131963 1.4136561567727603e-07 6.849656211030924 1.199701874410001 up IGAEVYHNLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGAEVYHNLK 10 0 P06733;A0A2R8Y6G6;K7EM90;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 0 1424469000.0 258144000.0 862417000.0 303908000.0 False True 391623320.8543181 708511948.2552243 243840450.5923916 1.0 1.8091668971848263 0.6226402709125155 28.544891437929913 -6.723080868620456 1.7480429128540078 1.490651407127348 0.6241360625023353 0.5271140763803291 0.3403775648866164 0.34935795098646205 2.087840870165907 0.15450622155125457 0.3864973321732914 1.89199128404853e-07 6.723080868620456 -0.8665153446250127 IGAEVYHNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGAEVYHNLK 10 0 P06733;A0A2R8Y6G6;K7EM90;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 0 855959730.0 363561000.0 193040030.0 299358700.0 False True 497979326.5666027 184510883.17658612 228656340.54595518 1.0 0.37051916281088537 0.4591683396225753 28.8915106096675 -10.732137312057045 6.939326250345022 1.0081000045944621 0.41484375121673034 0.983077874321899 0.03619087488440114 0.004522236560930146 0.000174561224585627 0.03494093148684927 0.011680554642663491 1.8529456799595243e-11 10.732137312057045 -0.5932562533777318 IGAEVYHNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGAEVYHNLK 10 0 P06733;A0A2R8Y6G6;K7EM90;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 0 469975000.0 168906000.0 215691000.0 85378000.0 False True 140452822.8045219 214529029.77168852 103230145.05673027 1.0 1.5274098838886543 0.7349809209630692 27.065510378971975 -6.727291828525748 1.732963271669441 1.3183515186847887 0.7356715586192486 0.5466645513331542 0.22176301496901435 0.3413713173853232 2.0071430462280917 0.10145841048404904 0.25255135249634836 1.8737350099467993e-07 6.727291828525748 -0.5826799600655401 IGAEVYHNLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGAEVYHNLK 10 0 P06733;A0A2R8Y6G6;K7EM90;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 0 910139000.0 258144000.0 411755000.0 240240000.0 False True 334172496.77898073 388840472.2882652 196518785.07056323 1.0 1.1635920850345787 0.5880758798667364 28.316017760022362 -6.8307700921198125 1.3246371497125757 1.0873641954015643 0.5723627716010351 0.9073742782517421 0.07369241111632772 0.17986379901647953 0.616987628387289 0.043678672169431734 0.10050610226791001 1.4764879532440594e-07 6.8307700921198125 -0.5150014238005292 IGAEVYHNLK(ub)NVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGAEVYHNLKNVIK 14 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 34900800.0 10231800.0 11276800.0 13392200.0 True False 13413988.884892147 9594345.396622116 12006503.61105348 1.0 0.7152492430814518 0.8950733233852696 23.67723497593048 -10.451702564176781 5.703687834292488 1.0001453308609367 0.8051612832333604 0.6101798400980891 0.07341287336827085 0.00013577182855552375 1.3051765464333252e-05 0.07113446900311876 0.02369390299604547 3.534251376549642e-11 10.451702564176781 -0.19498404762757626 IGAEVYHNLK(ub)NVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGAEVYHNLKNVIK 14 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 64874200.0 13838100.0 22335100.0 28701000.0 True False 13398817.090092966 31253621.906007826 21183347.088456154 1.0 2.3325657553095964 1.5809863621557338 23.675602302686613 -10.2040309820021 5.706193504905728 0.9999725306527528 1.956776058732693 0.6836219268190054 0.3068310024030355 0.00010722972498548155 1.4957805056714244e-05 0.2970963277180128 0.09902928020057528 6.251280953616707e-11 10.2040309820021 0.9568035280799402 IGAEVYHNLK(ub)NVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGAEVYHNLKNVIK 14 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 159791000.0 23036000.0 24061000.0 112694000.0 True False 34947296.15718388 19767126.56054896 90419981.50446518 1.0 0.565626779011502 2.5873240979153165 25.058677504031994 -6.850486238784111 1.2326941876859587 0.7680992686196997 2.6689269304168444 0.941017606259669 0.21103372398949 0.15692153686634097 0.45860170824305774 0.13394291768213074 0.31005869095092004 1.4109569438543632e-07 6.850486238784111 1.9008276617971447 up IGAEVYHNLK(ub)NVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGAEVYHNLKNVIK 14 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 44340400.0 10231800.0 15504200.0 18604400.0 True False 14014772.963998228 14819173.178466825 14210423.88964531 1.0 1.0573965926194435 1.013960335008614 23.740445037453373 -10.19306694447004 4.070551614702533 0.9999814756289356 1.0356784638192196 0.47357150997670383 0.017732777931010187 2.98261715105782e-06 5.91278982376262e-07 0.017178602656786546 0.005723229465031014 6.41110744735185e-11 10.19306694447004 0.035696988190283996 IGAEVYHNLK(ub)NVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGAEVYHNLKNVIK 14 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 55488500.0 13838100.0 26199000.0 15451400.0 True False 11506993.281773608 26057860.786905646 18682216.30079836 1.0 2.264523855087301 1.6235532465626688 23.45600757812089 -10.17146589111909 5.766928036201009 0.9999842640435754 1.9440385508250175 0.743081892557373 0.2616751551678788 5.2942810973378934e-05 7.606231632497175e-06 0.25337009302755265 0.08445529317343614 6.738048130796985e-11 10.17146589111909 0.9440542867814421 IGAEVYHNLK(ub)NVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGAEVYHNLKNVIK 14 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 116091300.0 23036000.0 23568300.0 69487000.0 True False 29820556.10744624 22256703.386799254 56841078.996829234 1.0 0.7463544042105144 1.9061039234823636 24.829803826124444 -6.849394031539503 1.2379741327239109 0.8647110527206651 1.9519369923274463 0.9394257829939797 0.12252141891027134 0.15812300311491662 0.46663587697992287 0.07745472046920651 0.17917091879206676 1.4145098253400835e-07 6.849394031539503 1.0872259396067814 IGAFGYMECSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGAFGYMECSAK 12 0 P61586 P61586 RHOA Transforming protein RhoA 0 28644400.0 9354900.0 8337500.0 10952000.0 False True 12264364.492980478 7093577.499320458 9818792.099002238 1.0 0.5783893248916789 0.8005952615499999 23.547969143392066 -10.042552463416444 4.983357369340411 1.0000051359186548 0.6894922932194535 0.7224987640744167 0.09071519378010724 125572900.13530388 9.145802410752438 7575.371511373567 0.031054223712356475 9.066664313208064e-11 10.042552463416444 -0.3105128426992013 IGAFGYMECSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGAFGYMECSAK 12 0 P61586 P61586 RHOA Transforming protein RhoA 0 8279600.0 3598200.0 1043000.0 3638400.0 False True 3483977.1105551017 1459475.3391731463 2685393.8903396744 1.0 0.41891071406626096 0.7707840221464058 21.73230371490357 -10.371917191824945 6.241805928799826 1.0000486684672154 0.5948473681063605 0.6386864304237087 0.14365167648358362 9.730213193751304e-05 9.790909966099765e-06 0.13910677748981273 0.04636337922297456 4.247005350962546e-11 10.371917191824945 -0.4052013003608549 IGAFGYMECSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGAFGYMECSAK 12 0 P61586 P61586 RHOA Transforming protein RhoA 0 24491000.0 9354900.0 4387100.0 10749000.0 False True 12813659.33666678 4193263.4158003456 8210307.58260399 1.0 0.32724948475890575 0.640746516423289 23.611179204914958 -10.52737775037073 6.361085066497714 1.0005084649841256 0.4839980005913742 0.783184844497004 0.12798462724248 0.0009237523064856037 6.863334517694628e-05 0.12403578369997723 0.04130686082339074 2.969082393363576e-11 10.52737775037073 -0.5165104643927514 IGAFGYMECSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGAFGYMECSAK 12 0 P61586 P61586 RHOA Transforming protein RhoA 0 6216460.0 3598200.0 866360.0 1751900.0 False True 2992062.7272875486 861692.7467210039 2118214.190129607 1.0 0.2879928749027834 0.7079444460878238 21.512708990337845 -9.17450881606042 9.270277076847636 1.0000000726323688 0.49796909225368613 0.655821531457426 0.17144451101692595 0.0 0.0 0.16600043399110254 0.05533347799703416 6.691002373543023e-10 9.17450881606042 -0.5020309803786827 IGASFLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGASFLQR 8 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 60707000.0 13660000.0 17534000.0 29513000.0 False True 17908392.28362818 14917995.54699668 26459277.868686374 1.0 0.8330170185424564 1.4774792426719063 24.094132490170413 -6.837922325310059 1.2921188294620047 0.911133658905884 1.4978047190297468 0.9208041353448855 0.07685221543998955 0.17124035946370797 0.5562731920410225 0.04665513317314711 0.10742554355655017 1.4523713547282237e-07 6.837922325310059 0.5866710601238627 IGASFLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGASFLQR 8 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 24280000.0 12530000.0 11750000.0 0.0 False True 10419250.173117947 11686700.417807596 0.0 1.0 1.121645053495281 0.0 23.31274812124749 -6.949298088137215 1.205158090573353 1.0683564341885794 4.6988898246577765e-19 0.9716312894174542 0.084642267203657 0.10795124443054799 0.31169191404982294 0.058375642145591225 0.11100574180880744 1.1238333399832325e-07 6.949298088137215 -1.0683564341885794 down IGCIITAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGCIITAR 8 0 Q12904;Q12904-2;A0A5F9ZHC5 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 0 11053400.0 2410800.0 4147400.0 4495200.0 False True 3160582.146220413 3528624.086438582 4030079.82500318 1.0 1.1164475160559557 1.2751068121493243 21.591758881560047 -6.966805685419594 0.3255757179413012 0.9796454309043802 1.4170687217219613 0.9999456718932432 0.0008310458467314818 0.07735344845697507 0.01272733296755904 0.0023530093356679905 0.01388909756623014 1.079429578904036e-07 6.966805685419594 0.43742329081758113 IGCPLTPLPPVSIAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGCPLTPLPPVSIAIR 16 0 Q15042;Q15042-3;Q15042-4 Q15042 RAB3GAP1 Rab3 GTPase-activating protein catalytic subunit 0 2611740.0 650310.0 1306800.0 654630.0 False True 852562.7076109978 1111830.533866502 586895.1672543674 1.0 1.3041041133291058 0.688389442811698 19.701446425444338 -6.772389310030512 1.5651125265637098 1.173892064275658 0.684592492925243 0.7396840650142988 0.12825225533199217 0.2625833987689408 1.2697012172363664 0.06457533133080821 0.153393929908628 1.6889262664636133e-07 6.772389310030512 -0.489299571350415 IGCPLTPLPPVSIAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGCPLTPLPPVSIAIR 16 0 Q15042;Q15042-3;Q15042-4 Q15042 RAB3GAP1 Rab3 GTPase-activating protein catalytic subunit 0 3612510.0 650310.0 1009900.0 1952300.0 False True 890747.1809669543 965279.2787072953 1491206.9488806175 1.0 1.0836736835466965 1.674107963229063 19.76465648696723 -6.932507914768009 0.7259083947755216 0.9918039155742152 1.803445072939724 0.9970086722195571 0.016408267921134805 0.09135615951998449 0.071452121870609 0.01517833627044886 0.052706630779787995 1.168132441123134e-07 6.932507914768009 0.8116411573655088 IGDEDVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGDEDVGR 8 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 58314300.0 1117300.0 31459000.0 25738000.0 False True 1464791.1199485906 26765439.826221533 23074878.656329397 1.0 18.272530097780024 15.753016482745505 20.48226351950095 -9.637787134459565 11.0326231400762 0.9997712237085358 17.012752769385234 0.9817706318091761 1.0285871347553983 0.0 0.0 0.9959252071107335 0.3319750690369111 2.3025701249411804e-10 9.637787134459565 16.0129815456767 IGDEDVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGDEDVGR 8 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 49984000.0 16393000.0 5670000.0 27921000.0 False True 15872613.188074512 7934060.568659378 20607652.487954605 1.0 0.4998584968113779 1.298315043891931 23.9200363300733 -6.7373722134102625 1.6964321846339612 0.7015104675429521 1.2985083301961193 0.593016263015404 0.21015530724977208 0.3226027383384111 1.8219226082917543 0.09804571843588789 0.24128220457720334 1.8307447044690168e-07 6.7373722134102625 0.5969978626531672 IGDEDVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGDEDVGR 8 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 48365300.0 1117300.0 21897000.0 25351000.0 False True 1530396.0038971845 20929518.136304215 19363615.920233853 1.0 13.675883943114574 12.652683273429892 20.545473581023842 -10.617854292800049 12.18817724565847 0.9997324368148623 13.164283608272232 0.9947214903309755 0.4177199242002512 0.003036954779961976 9.52206069407416e-05 0.40444167047970087 0.13481852581721637 2.410714095381157e-11 10.617854292800049 12.164551171457369 IGDEDVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGDEDVGR 8 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 4340760.0 812160.0 1183300.0 2345300.0 False True 1051357.1300670048 1117448.3147957032 1918479.4648101588 1.0 1.0628627350674706 1.8247647825319744 20.003821383494714 -6.923249967758953 0.8002485634739902 0.9850759484013419 1.957309831483665 0.9950372429806139 0.026407734813082315 0.09629695726604112 0.09597879402327592 0.023153776284436448 0.07166690704897626 1.1933010760367722e-07 6.923249967758953 0.9722338830823231 IGDEYFTFITDCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGDEYFTFITDCK 13 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 1356670.0 429940.0 926730.0 0.0 False True 563655.5035448823 788465.4963652467 0.0 1.0 1.3988428950068141 0.0 19.104454156251713 -6.858042446362449 1.3879297766343817 1.2109081591123239 2.4009131811478325e-22 0.9059794188896645 0.18041705219276444 0.1671994549327811 0.6474689316910962 0.10475578030286374 0.21911204053812378 1.3866202990261906e-07 6.858042446362449 -1.2109081591123239 down IGDEYFTFITDCK(ub)DPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGDEYFTFITDCKDPK 16 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 80533400.0 7488400.0 14215000.0 58830000.0 True False 11360450.275371414 11678222.187698077 47202224.713895 1.0 1.0279717708914733 4.154960725124233 23.43751668190373 -6.908859485709199 0.9034758996461759 0.8996555642753167 4.549353596838283 0.9904837883753755 0.14444521565640214 0.1051767869148903 0.1428975515655038 0.1175963854679075 0.32210666790507075 1.2335038640515436e-07 6.908859485709199 3.649698032562966 up IGDEYFTFITDCK(ub)DPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGDEYFTFITDCKDPK 16 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 15040400.0 2417400.0 4153800.0 8469200.0 True False 3311178.107778622 3970271.3812202774 6468949.388649143 1.0 1.1990509878925912 1.9536700165576364 21.658913184498243 -6.9461090970774 0.600053187194161 0.9915013506523451 2.1998516693618018 0.998859389557685 0.013872764850381922 0.08508699530015791 0.0427275758975466 0.014237465947076516 0.06341717080976793 1.1321159339844991e-07 6.9461090970774 1.2083503187094566 IGDEYFTFITDCK(ub)DPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGDEYFTFITDCKDPK 16 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 96510400.0 7488400.0 14066000.0 74956000.0 True False 9693881.418432044 13283214.734992258 61314777.113507904 1.0 1.3702679207252753 6.325100799863651 23.20864300399618 -6.921880748769711 0.8106449811441584 0.897908778529608 7.1597607480520375 0.9946878196808556 0.176943234116208 0.09707784272235942 0.09996901817826438 0.153993107259426 0.46992082016510006 1.197069184748421e-07 6.921880748769711 6.2618519695224295 up IGDEYFTFITDCKDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGDEYFTFITDCKDPK 16 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 24485100.0 4014100.0 10092000.0 10379000.0 False True 5262523.972599702 8586312.938307896 9305080.64239812 1.0 1.631595976192054 1.7681782906542056 22.327323469488373 -11.318991750276265 0.27499212158493097 7.146452368573313e-11 1.8183443500603182 0.9992925384350583 0.00889996710728033 3.5401184609918652 0.14784380993237792 2.2008778358970593 0.05513151876458737 4.797425615915442e-12 11.318991750276265 1.8183443499888536 IGDEYFTFITDCKDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGDEYFTFITDCKDPK 16 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 27435100.0 4014100.0 10571000.0 12850000.0 False True 5498221.246973685 10103938.266377674 9815094.65405724 1.0 1.8376740062868613 1.7851399958595038 22.390533531011265 -10.142663943221631 4.573002467109891 0.9999027374778179 1.8114070010877665 0.9968659805814807 0.02144692000106669 11332865.394553244 2.246397228381385 11625.087452068332 0.007848769039135988 7.200059025857492e-11 10.142663943221631 0.8115042636099487 IGDFGLATVK(ub)TR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGDFGLATVKTR 12 1 Q96II5;P10398 Q96II5 ARAF Serine/threonine-protein kinase A-Raf 1 3810380.0 942680.0 873600.0 1994100.0 True False 1235862.6089261053 743262.2852661292 1787769.6607578837 1.0 0.6014117426143203 1.4465763814242705 20.23708693680734 -6.778452623576801 1.5418095836514283 0.7738557327758896 1.452959672191529 0.7619025244397786 0.168452056888658 0.2529883737299546 1.1877564423143687 0.08606022359437818 0.20333784626258647 1.6655105054948286e-07 6.778452623576801 0.6791039394156394 IGDFGLATVK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGDFGLATVKTR 12 1 Q96II5;P10398 Q96II5 ARAF Serine/threonine-protein kinase A-Raf 1 4163140.0 911040.0 1375400.0 1876700.0 True False 882119.5338780823 1924604.3926162464 1385135.9702068132 1.0 2.181795458213088 1.5702361380858536 19.75061463957153 -10.164649807481872 5.64810897460454 0.9999832365648779 1.876015798149531 0.7323202090928285 0.2496680469593983 5.270343293639426e-05 7.794831987224806e-06 0.24174466057473773 0.08058001566279249 6.844633405180739e-11 10.164649807481872 0.876032561584653 IGDFGLATVK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGDFGLATVKTR 12 1 Q96II5;P10398 Q96II5 ARAF Serine/threonine-protein kinase A-Raf 1 4215540.0 911040.0 2098600.0 1205900.0 True False 757570.1259151923 2087294.4252605122 1458048.114548374 1.0 2.7552491232926184 1.9246378185609685 19.531019915005807 -9.806087635870082 6.175086655589478 0.9999999431803401 2.3399434709278717 0.7762809711147743 0.3390956452005031 2.6542624635099203e-07 5.070664983193591e-08 0.32832796133373776 0.1094426488855189 1.562832248388789e-10 9.806087635870082 1.3399435277475316 IGDFGLVTSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGDFGLVTSLK 11 0 P19525-2;P19525 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 0 10722300.0 2566000.0 3358300.0 4798000.0 False True 3364050.8491793456 2857254.730550869 4301548.985665875 1.0 0.8493494476303446 1.278681321572541 21.68176808208264 -6.811900328595956 1.4065872087146898 0.9180788051200259 1.2865187895260721 0.8647102422797515 0.06541740112962327 0.20422614591752913 0.7960065420416831 0.036565989746280246 0.08451191471872295 1.5420543167206617e-07 6.811900328595956 0.3684399844060462 IGDFGLVTSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGDFGLVTSLK 11 0 P19525-2;P19525 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 0 9793300.0 2615400.0 2655000.0 4522900.0 False True 2532375.5585975777 3715155.34564209 3338216.8059084513 1.0 1.4670633402020086 1.3182155366233064 21.27205994579178 -9.974566296738033 4.872418285594275 0.9999963411828416 1.392639438353296 0.9027022466098296 0.06076686138892577 8047605.024419996 16474648.332185635 203.42750100888955 0.020802110871413128 1.0603120652658439e-10 9.974566296738033 0.3926430971704544 IGDFGLVTSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGDFGLVTSLK 11 0 P19525-2;P19525 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 0 8718600.0 2566000.0 2706000.0 3446600.0 False True 3514719.5435426254 2586439.9724546396 2632584.064955146 1.0 0.7358880105260587 0.7490168226343488 21.744978143605532 -10.012064425367102 7.061319571249202 1.0000000272100062 0.7424524165830048 0.9980548545292928 0.005359815099031329 2.2978357871895605e-09 3.23066408051824e-10 0.005189619234308673 0.001729872884774859 9.726029323998623e-11 10.012064425367102 -0.2575476106270015 IGDGMNAYVAYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGDGMNAYVAYK 12 0 Q13596;Q13596-3 Q13596 SNX1 Sorting nexin-1 0 17800200.0 4757900.0 5338100.0 7704200.0 False True 6237652.975569138 4541676.287750825 6907043.28790476 1.0 0.7281065980328013 1.107314452239874 22.572571861639997 -6.714219663515507 1.779858827297246 0.8335762674213022 1.106551772840689 0.48527852945731575 0.11450146521554676 0.36664498909554455 2.2665656695168677 0.05114224887703944 0.12927968691738387 1.9309913862407466e-07 6.714219663515507 0.27297550541938687 IGDGMNAYVAYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGDGMNAYVAYK 12 0 Q13596;Q13596-3 Q13596 SNX1 Sorting nexin-1 0 13196800.0 5121800.0 1469900.0 6605100.0 False True 4959211.26253158 2056838.7354272383 4875026.161247404 1.0 0.4147511825050305 0.9830244978833184 22.24167925483175 -10.915732062617748 10.727029892954503 1.0375650188111667 0.6988878401941745 0.2723846594683702 0.2319966095194177 0.12605576009565828 0.0009902500308949646 0.1358573770599428 0.07487658375377412 1.2141376800154288e-11 10.915732062617748 -0.3386771786169922 IGDSSQGDNNLQK(ub)LGPDDVSVDIDAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGDSSQGDNNLQKLGPDDVSVDIDAIR 27 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 39811700.0 14958000.0 7766700.0 17087000.0 True False 14483166.477595245 10867983.81280545 12611402.1009878 1.0 0.7503872740548617 0.8707627658977078 23.78787371981665 -10.120067284322175 4.62054944957493 1.0000158380117874 0.8105750199735724 0.7675335486248849 0.04914308877162654 68551605.38974635 0.24928967971583044 11873.84312056071 0.016822986414103056 7.584600593192328e-11 10.120067284322175 -0.189440818038215 IGDSSQGDNNLQK(ub)LGPDDVSVDIDAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGDSSQGDNNLQKLGPDDVSVDIDAIR 27 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 81304000.0 19718000.0 27962000.0 33624000.0 True False 29913647.578891844 22971962.631896846 26978201.66207728 1.0 0.767942544329054 0.9018693421097226 24.834300503225418 -10.186113595067168 4.9956244325773955 1.0000141860077023 0.834905943291684 0.6695445908934374 0.05467538624206595 8.639343341911044e-06 1.4075299168175816e-06 0.05294376292813977 0.017646405030132633 6.514579749225227e-11 10.186113595067168 -0.16510824271601832 IGDSSQGDNNLQK(ub)LGPDDVSVDIDAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGDSSQGDNNLQKLGPDDVSVDIDAIR 27 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 41899000.0 14958000.0 14076000.0 12865000.0 True False 12438239.751755642 14000169.794132762 15555012.018960807 1.0 1.125574846083559 1.2505798512820303 23.568278995250925 -6.971182046582207 0.2282107630947977 0.9480093929918597 1.4317093534519127 0.9999901853455778 0.00032043350470266357 0.07592109727140951 0.007644210382588365 0.0032547343392506796 0.012459008333688184 1.0686068491162707e-07 6.971182046582207 0.48369996046005304 IGDSSQGDNNLQK(ub)LGPDDVSVDIDAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGDSSQGDNNLQKLGPDDVSVDIDAIR 27 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 71121000.0 19718000.0 22829000.0 28574000.0 True False 25525339.699888248 21558546.081696164 23373825.19399882 1.0 0.8445938951320029 0.9157106416139549 24.605426825317867 -10.143261085532592 4.591116879660504 1.000013971437977 0.8801522683709073 0.7910854071195863 0.029033290181682485 4.152487803936669e-06 7.748965665106671e-07 0.028114638841775563 0.009370454112274737 7.190165956516884e-11 10.143261085532592 -0.11986170306706967 IGDTSVSYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGDTSVSYK 9 0 P20700 P20700 LMNB1 Lamin-B1 0 5184240.0 359540.0 2421700.0 2403000.0 False True 492471.65420316235 2314701.2865090165 1835460.891338483 1.0 4.700171607347209 3.727038654251741 18.909681162422256 -10.360479143181445 6.810034538004952 0.9998581533822679 4.213605130799466 0.9356520145687666 0.3972798644952754 0.0008556534671624383 8.035120978681703e-05 0.3846796449947608 0.12822152491447844 4.3603450387999365e-11 10.360479143181445 3.213746977417198 IGDTWSK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGDTWSKK 8 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 1 14258570.0 527270.0 1474300.0 12257000.0 True False 510532.1024630062 2062995.6783729314 9046523.997881869 1.0 4.040873567832923 17.719794610834274 18.961642155633964 -6.942188584852716 0.6388812653544035 0.8503617558828835 21.658826598044964 0.9984367061310688 0.28751603933834274 0.08678231134483336 0.0501688548334288 0.2847544322677442 1.166438285017062 1.1423821674120911e-07 6.942188584852716 20.80846484216208 IGDTWSK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGDTWSKK 8 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 1 16928670.0 527270.0 2151400.0 14250000.0 True False 438448.3670215403 2139809.981180538 17229609.115444344 1.0 4.8804149864136965 39.29678021721969 18.74204743106824 -6.92822906255282 0.7611859010579359 0.44080156194723685 46.05390983240217 0.9961786264411616 1.0639808496064473 0.09356791560062408 0.08226130583761525 0.9593160493795497 3.144959857452247 1.1796982561810479e-07 6.92822906255282 45.61310827045493 IGDVVGSSGANQQTSGK(ub)VLYEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGDVVGSSGANQQTSGKVLYEGK 23 1 Q9Y263;E5RIM3;H0YBW4 Q9Y263 PLAA Phospholipase A-2-activating protein 1 24602300.0 3918200.0 5869100.0 14815000.0 True False 5136798.143902771 4993453.157572614 13282085.915514806 1.0 0.9720944872049716 2.585674099590667 22.292437951844512 -6.902965542115721 0.942324519669883 0.9382621235962851 2.7656311114811944 0.9879849544876446 0.08266557605061114 0.10925536997304079 0.16536238574792328 0.06540873537598058 0.17286060771286427 1.2503582324685068e-07 6.902965542115721 1.8273689878849093 up IGDVVGSSGANQQTSGK(ub)VLYEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGDVVGSSGANQQTSGKVLYEGK 23 1 Q9Y263;E5RIM3;H0YBW4 Q9Y263 PLAA Phospholipase A-2-activating protein 1 33681400.0 4808200.0 5169200.0 23704000.0 True False 4655566.322875619 7233288.517021889 17495211.295242872 1.0 1.5536860642453656 3.757912589340269 22.150525243339953 -6.94498398223969 0.6114398089558355 0.9756671146314779 4.451004860268042 0.9987465173920627 0.042174976599833956 0.08556465162688538 0.044795584737261016 0.0428116582456373 0.18596066036187645 1.1350526782038968e-07 6.94498398223969 3.4753377456365637 IGDVVGSSGANQQTSGK(ub)VLYEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGDVVGSSGANQQTSGKVLYEGK 23 1 Q9Y263;E5RIM3;H0YBW4 Q9Y263 PLAA Phospholipase A-2-activating protein 1 67115200.0 5194200.0 35996000.0 25925000.0 True False 7879981.146885071 29572232.561968297 20800912.386668824 1.0 3.7528303698617473 2.6397160093322496 22.90976074731446 -10.427087837461624 6.364063095618103 0.9995038223371612 3.1962731895969987 0.8384692359259042 0.45442703477694396 0.0031997248471488317 0.0002880483741224915 0.44007302454957914 0.14666569481312677 3.740349308485319e-11 10.427087837461624 2.1967693672598374 IGDVVGSSGANQQTSGK(ub)VLYEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGDVVGSSGANQQTSGKVLYEGK 23 1 Q9Y263;E5RIM3;H0YBW4 Q9Y263 PLAA Phospholipase A-2-activating protein 1 19639000.0 3918200.0 2824800.0 12896000.0 True False 5366864.425373621 2699990.995635572 9850230.40145696 1.0 0.503085373811657 1.83537902595168 22.355648013367404 -6.805697627309437 1.4325335336317075 0.7277777804759277 1.8564647891819734 0.8482989487725469 0.21411180757437473 0.2127255900398681 0.8611540431058232 0.11755144862365224 0.2724897442455955 1.5642363457124727e-07 6.805697627309437 1.1286870087060459 IGDVVGSSGANQQTSGK(ub)VLYEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGDVVGSSGANQQTSGKVLYEGK 23 1 Q9Y263;E5RIM3;H0YBW4 Q9Y263 PLAA Phospholipase A-2-activating protein 1 24022700.0 4808200.0 7817500.0 11397000.0 True False 3998231.339376355 7775385.575847744 13780060.006225899 1.0 1.9447062753153623 3.446538940984669 21.93093051877423 -6.96427400156156 0.3703070081981552 0.8849091692940086 4.558637269248644 0.9998973804713033 0.010204996802745251 0.07820826307559324 0.015734346281165976 0.019786082326299716 0.12752860429374746 1.0857404009309015e-07 6.96427400156156 3.6737280999546353 IGDVVGSSGANQQTSGK(ub)VLYEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGDVVGSSGANQQTSGKVLYEGK 23 1 Q9Y263;E5RIM3;H0YBW4 Q9Y263 PLAA Phospholipase A-2-activating protein 1 74530200.0 5194200.0 54186000.0 15150000.0 True False 6723994.292989115 51170501.46667785 12392855.452127185 1.0 7.610134577304985 1.843079412641501 22.68088706940691 -6.613095241415083 2.141355352433473 5.406848311970985 1.8638032974997298 0.06034023637308772 2.847559346434352 0.6042121836123558 5.254165380854751 1.0961589847554534 3.161528681716813 2.437276261507421e-07 6.613095241415083 -3.5430450144712555 IGEEEIQKPEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGEEEIQKPEEK 12 1 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 7095770.0 1748100.0 902970.0 4444700.0 False True 1692607.522361561 1263530.6299263446 3280499.731858162 1.0 0.7464994768329049 1.938133730660219 20.690816052785106 -6.851089846986579 1.2297930775630257 0.864586203281312 1.9867892810440202 0.9418819243402766 0.12356350101518393 0.15626002606164188 0.45421898033319197 0.07859862236147089 0.18201601881493903 1.4089972744437772e-07 6.851089846986579 1.1222030777627081 IGEENNK(ub)VVEELIEENNDMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGEENNKVVEELIEENNDMK 20 1 O94986;O94986-1;O94986-2 O94986 CEP152 Centrosomal protein of 152 kDa 1 17056100.0 3846100.0 7021400.0 6188600.0 True False 5042274.3456853805 5973834.489202833 5548263.037242995 1.0 1.1847499917005861 1.1003492981278544 22.26564318541672 -10.208903833903959 4.22675800665059 0.999935405717204 1.1425496449222245 0.7918167772608034 0.034456438891859925 24243275.0164482 1.7789957359023483 15240.81686469999 0.011795355516286885 6.181532630448318e-11 10.208903833903959 0.1426142392050206 IGEENNK(ub)VVEELIEENNDMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGEENNKVVEELIEENNDMK 20 1 O94986;O94986-1;O94986-2 O94986 CEP152 Centrosomal protein of 152 kDa 1 24914800.0 11046000.0 7479600.0 6389200.0 True False 10695350.776274715 10466243.285598725 4715676.848108569 1.0 0.9785787773146988 0.4409090404560888 23.350480463675055 -6.915295636471435 0.8588858577897145 1.013991039993436 0.3629373448287155 0.9927713257423363 0.0219914215988676 0.1010196760780113 0.12054052575064805 0.018490074399999355 0.05312363433421529 1.215358390342663e-07 6.915295636471435 -0.6510536951647206 down IGEENNK(ub)VVEELIEENNDMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGEENNKVVEELIEENNDMK 20 1 O94986;O94986-1;O94986-2 O94986 CEP152 Centrosomal protein of 152 kDa 1 56474000.0 13204000.0 29247000.0 14023000.0 True False 20031433.341702398 24027644.342146005 11251347.903500745 1.0 1.1994970071424746 0.5616846139550657 24.25576232055842 -6.822671625677288 1.360435307420257 1.107246631891677 0.5469655847467177 0.8903754141273755 0.08820422183994642 0.19004042781324565 0.6904020506126579 0.05094121542187344 0.11732667950103604 1.504278936275029e-07 6.822671625677288 -0.5602810471449592 IGEENNK(ub)VVEELIEENNDMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGEENNKVVEELIEENNDMK 20 1 O94986;O94986-1;O94986-2 O94986 CEP152 Centrosomal protein of 152 kDa 1 18476500.0 3846100.0 5887300.0 8743100.0 True False 5268107.106944387 5627179.619302355 6678159.849796711 1.0 1.0681596833679863 1.2676583285471932 22.328853246939612 -6.952003551242749 0.5363956818460028 0.9969911904268735 1.347982995846855 0.9993492865196977 0.002897100213760008 0.08269102606152649 0.03270873349162722 0.003202492997886479 0.01651214859383167 1.1168541151839954e-07 6.952003551242749 0.35099180541998154 IGEEQSAEDAEDGPPELLFIHGGHTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGEEQSAEDAEDGPPELLFIHGGHTAK 27 0 Q16576;E9PC52;Q16576-2;Q5JNZ6 Q16576 RBBP7 Histone-binding protein RBBP7 0 40253200.0 6571200.0 17719000.0 15963000.0 False True 8614906.835591318 15075394.268121032 14311301.88790838 1.0 1.74991959353978 1.6612253807299668 23.038403764084652 -10.083159691811533 4.250925769512411 0.99991194746714 1.705572487242861 0.988287439375493 0.03620926116339901 2463826.3186221565 1672542.3508357592 1839.4203269278655 0.012395393307566773 8.257342679674894e-11 10.083159691811533 0.7056605397757211 IGEEQSAEDAEDGPPELLFIHGGHTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGEEQSAEDAEDGPPELLFIHGGHTAK 27 0 Q16576;E9PC52;Q16576-2;Q5JNZ6 Q16576 RBBP7 Histone-binding protein RBBP7 0 35237200.0 6571200.0 14280000.0 14386000.0 False True 9000750.220002847 13649062.382354856 10988323.088970235 1.0 1.5164360801860512 1.220823022568752 23.101613825607544 -10.153782232274727 4.765133075678088 0.9999657833266251 1.3686295513797821 0.6746217419798679 0.1206835254192708 84453493.7520684 1.6055823822324278 31707.297542288434 0.04131318074337787 7.018071164494165e-11 10.153782232274727 0.36866376805315704 IGEEQSPEDAEDGPPELLFIHGGHTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGEEQSPEDAEDGPPELLFIHGGHTAK 27 0 Q09028-3;Q09028;Q09028-2;Q09028-4;H0YF10;H0YCT5;H0YDK2;H0YEU5 Q09028-3;H0YDK2 RBBP4 Histone-binding protein RBBP4 0 46010000.0 4864000.0 19219000.0 21927000.0 False True 6376751.10304301 16351600.115075234 19658204.37863605 1.0 2.5642525246551 3.082793112193932 22.604390140436546 -9.780414945801626 0.292038318235915 2.74144941782406e-26 3.2883327345927693 0.9988479400626492 0.030048843846677477 1.1680301699339408 0.1253893794739026 1.224603990371975 0.18957735128559575 1.6580020156788505e-10 9.780414945801626 3.2883327345927693 IGEEQSPEDAEDGPPELLFIHGGHTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGEEQSPEDAEDGPPELLFIHGGHTAK 27 0 Q09028-3;Q09028;Q09028-2;Q09028-4;H0YF10;H0YCT5;H0YDK2;H0YEU5 Q09028-3;H0YDK2 RBBP4 Histone-binding protein RBBP4 0 49274600.0 12315000.0 4888600.0 32071000.0 False True 11924067.065890184 6840643.473712217 23670642.99062325 1.0 0.5736837469893526 1.9851148823487546 23.507373058990314 -6.825694508536259 1.3469872207276707 0.7714392330228275 2.019874632605864 0.8969927519379395 0.1897042338710906 0.18618711399109716 0.6621598691550331 0.11062309817691826 0.2546746010209467 1.493844840561417e-07 6.825694508536259 1.2484353995830364 IGEEQSPEDAEDGPPELLFIHGGHTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGEEQSPEDAEDGPPELLFIHGGHTAK 27 0 Q09028-3;Q09028;Q09028-2;Q09028-4;H0YF10;H0YCT5;H0YDK2;H0YEU5 Q09028-3;H0YDK2 RBBP4 Histone-binding protein RBBP4 0 43540000.0 4864000.0 16139000.0 22537000.0 False True 6662352.244657583 15425925.615463924 17214224.76408467 1.0 2.315387275993053 2.583805858942454 22.667600201959438 -10.377569125746003 0.342636371435761 3.707772472283591e-25 2.6395128987754384 0.999062095667738 0.02119500743849812 1.8448517093067385 0.1614218098173496 1.738210238826505 0.08159744895873791 4.192092667103164e-11 10.377569125746003 2.6395128987754384 IGEGTYGVVYK(ub)GR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGEGTYGVVYKGR 13 1 P06493;A0A024QZP7;P06493-2;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 14391400.0 0.0 4339400.0 10052000.0 True False 0.0 6072145.0496720495 7419079.646463934 0.0 IGEHTPSALAIMENANVLAR ddPTM_RPMI8226_Bortezomib_1h_R1 2 IGEHTPSALAIMENANVLAR 20 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BR04;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 124737100.0 17529200.0 77448900.0 29759000.0 False True 22980950.953014255 65893826.01344771 26679824.14848497 1.0 2.867323730343929 1.1609538788465827 24.4539351622309 -6.624725276866781 2.099788390773828 2.234910039153997 1.1676764259521029 0.0988219101734289 0.8020543457747104 0.5728185229932228 4.805804045876805 0.31317954855399055 0.8887578014133787 2.3728742481201486e-07 6.624725276866781 -1.0672336132018942 IGEHTPSALAIMENANVLAR ddPTM_RPMI8226_Bortezomib_2h_R1 2 IGEHTPSALAIMENANVLAR 20 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BR04;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 210634600.0 73737200.0 39798400.0 97099000.0 False True 71396452.94770263 55690108.66591418 71665858.99243951 1.0 0.7800122606469927 1.0037733813601948 26.089349065610534 -11.028598536950042 9.803426887397485 1.2061665497959948 0.8918928210015155 0.23735607949927595 0.09135009500344284 0.05405958398919312 0.00015770261109248428 0.011616121375757646 0.02948311638523328 9.362707655887666e-12 11.028598536950042 -0.31427372879447935 IGEHTPSALAIMENANVLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGEHTPSALAIMENANVLAR 20 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BR04;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 377804600.0 5844000.0 363410000.0 8550600.0 False True 8865775.253628341 298556646.16471016 6860570.162138887 1.0 33.67518774430077 0.7738263113912324 23.07981536013938 -3.0553102421543543 16.433765927627096 9.999999999975085 16.651909593574516 0.0 15.563170153287512 0.0 0.0 5.108138728688465 0.0 0.0008804197126014709 3.0553102421543543 6.651909593599431 IGEHTPSALAIMENANVLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 IGEHTPSALAIMENANVLAR 20 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BR04;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 189829600.0 17529200.0 77825900.0 94474500.0 False True 24010218.948818155 74387294.40216452 72161568.86340308 1.0 3.0981514396321677 3.0054523458210722 24.51714522375379 -10.307150634274917 4.403275819517547 0.9981747239876846 3.051801892743805 0.998471459130343 0.037844246634062384 13441578.622075504 724.3561016754367 248752.28253885257 0.012955092212177536 4.9300277715292e-11 10.307150634274917 2.0536271687561203 IGEHTPSALAIMENANVLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IGEHTPSALAIMENANVLAR 20 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BR04;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 98694100.0 73737200.0 11229500.0 13727400.0 False True 61315748.91183019 11169004.45461876 16597735.871673724 1.0 0.18215555795753846 0.27069286710565443 25.86975434104481 -10.489051105204034 6.174571616191524 1.0005415172862926 0.22642421306558239 0.9902711323674271 0.03614520510198902 0.0002696185036159806 2.2311022876920085e-05 0.03501985414677764 0.011665814783771213 3.2430145322845935e-11 10.489051105204034 -0.7741173042207102 IGEHTPSALAIMENANVLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGEHTPSALAIMENANVLAR 20 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BR04;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 27462400.0 5844000.0 11736000.0 9882400.0 False True 7565173.202462048 11082881.28322687 8083904.601986913 1.0 1.4649871174952083 1.0685683441267473 22.85094168223183 -10.255947550437657 5.925935429375617 0.999989602167884 1.266777730810979 0.37650050535097823 0.16183728653546037 2.2232937207329572e-05 2.79151401796538e-06 0.1567043819230774 0.05223275962893565 5.5469269891738694e-11 10.255947550437657 0.2667881286430951 IGFDAIMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGFDAIMR 8 0 O94855;O94855-2;E9PDM8;E9PC44 O94855 SEC24D Protein transport protein Sec24D 0 4565750.0 880150.0 1618900.0 2066700.0 False True 1153885.1733847249 1377366.4304227752 1852857.709186262 1.0 1.1936772065304437 1.6057557128940487 20.138068233488852 -6.958817112802063 0.451800205481847 0.9869531268492762 1.8288649047449983 0.9997237671507575 0.004198267484822488 0.08012646944989259 0.022713670602698195 0.0055228231949895875 0.034076772746018634 1.0994687429080579e-07 6.958817112802063 0.8419117778957221 IGFDAIMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGFDAIMR 8 0 O94855;O94855-2;E9PDM8;E9PC44 O94855 SEC24D Protein transport protein Sec24D 0 3576050.0 880150.0 1019800.0 1676100.0 False True 1205565.2401594096 974741.8639723713 1280239.7003630616 1.0 0.8085351431030668 1.0619414509610263 20.201278295011743 -6.704586199003865 1.8144923391056285 0.8816515412357988 1.0612584587595795 0.4395064173075256 0.080753016023442 0.3859892379290049 2.473704288652955 0.03546295825745367 0.0906893511759652 1.9743029797942148e-07 6.704586199003865 0.17960691752378066 IGFDVVTLSGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGFDVVTLSGTR 12 0 Q5TDF0;Q9BSD7 Q5TDF0 NTPCR Cancer-related nucleoside-triphosphatase 0 19792600.0 0.0 7986600.0 11806000.0 False True 0.0 7633725.6038456 9017665.952202303 0.0 IGFGSFVDK(ub)TVLPFVSTVPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGFGSFVDKTVLPFVSTVPSK 21 1 P26010;P26010-2;F5H6T4 P26010 ITGB7 Integrin beta-7;Integrin beta 1 176515400.0 1069400.0 11872000.0 163574000.0 True False 1035452.4823599636 16612551.511662133 120729062.28518619 1.0 16.043760379809456 116.59546366630474 19.981829918115245 -6.933457012778431 0.7211892502999249 5.177197458852472e-17 138.9318590816845 0.9972232591336669 2.7040449994879423 0.09008083574882052 0.06936301356201512 2.5299225555603475 8.851404331993526 1.1655824164980948e-07 6.933457012778431 138.9318590816845 IGFGSFVDK(ub)TVLPFVSTVPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGFGSFVDKTVLPFVSTVPSK 21 1 P26010;P26010-2;F5H6T4 P26010 ITGB7 Integrin beta-7;Integrin beta 1 110501800.0 1069400.0 8772000.0 100660400.0 True False 889253.4824526986 8724743.494894335 121708024.23889616 1.0 9.811312147836794 136.86538949862373 19.76223519354952 -6.918365596141612 0.8401495213461357 6.262895911643337e-17 156.373960125808 0.9943889229279935 4.6498617522913515 0.09573324646369684 0.10800111955462885 4.05010541904957 11.889300970543657 1.20679750566405e-07 6.918365596141612 156.373960125808 IGFK(ub)LGVRPSQGGEAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGFKLGVRPSQGGEAPR 17 2 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 1 8284700.0 1087200.0 1938300.0 5259200.0 True False 1425329.7284597766 1649113.1954342234 4715028.433808668 1.0 1.1570047003904627 3.308026444452097 20.44286427287299 -6.921570991178809 0.8129892645959236 0.9551728620990438 3.667751043492207 0.9946063096177976 0.07733125489853651 0.09725627154047697 0.10088866475614044 0.06718909180729367 0.2043881454402024 1.197923290774296e-07 6.921570991178809 2.7125781813931633 up IGFK(ub)LGVRPSQGGEAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGFKLGVRPSQGGEAPR 17 2 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 1 9062400.0 1796500.0 3041600.0 4224300.0 True False 1739471.090854381 4256126.741734462 3117829.1037164377 1.0 2.4467936053159516 1.792400644143528 20.730217271606154 -10.642076310559894 6.023799760132836 0.9921837014704795 2.119597124729739 0.7960381901979587 0.267154807690227 0.027910422725222827 0.0016583868571032896 0.25744152043369145 0.08622384342029125 2.2799414247431815e-11 10.642076310559894 1.1274134232592596 IGFK(ub)LGVRPSQGGEAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGFKLGVRPSQGGEAPR 17 2 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 1 5603700.0 1796500.0 2573300.0 1233900.0 True False 1493869.3484442432 2559437.122139939 1491902.7850910013 1.0 1.7132938197074647 0.9986835774123822 20.51062254704043 -10.552325126366826 5.714043460756525 0.999015076765374 1.3559886985599086 0.24861838862935903 0.2917384097649347 0.0036700178007814115 0.00028753193884396914 0.2832082969523465 0.09415816687238555 2.8033341889640396e-11 10.552325126366826 0.3569736217945345 IGFLGLGLMGSGIVSNLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGFLGLGLMGSGIVSNLLK 19 0 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 0 1917730000.0 698690000.0 688670000.0 530370000.0 False True 1059963811.0810387 565771457.8967303 425542137.03057075 1.0 0.5337648813875162 0.4014685525881942 29.981367863618914 -13.999999999999998 0.17667844377707181 3.3951595884600736 0.29269468827459966 0.9995025223072255 0.005725793247731166 12.163569620377304 0.1332129692350026 9.99424206359612 0.10163787061854594 1.0000000000000041e-14 13.999999999999998 -3.102464900185474 IGFPWSEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGFPWSEIR 9 0 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 33377400.0 8176400.0 10474000.0 14727000.0 False True 10719339.580370246 8911320.027332217 13203191.311359208 1.0 0.8313310685343938 1.2317168620665313 23.353712688153237 -6.792244968563714 1.487177375745143 0.9060055325235562 1.2362530132715488 0.8085697386207904 0.07181179098168869 0.23201934300319346 1.0136649088380498 0.03800160813794564 0.0888345089968862 1.6134482169519287e-07 6.792244968563714 0.3302474807479926 IGFPWSEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGFPWSEIR 9 0 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 29953400.0 10895000.0 5879400.0 13179000.0 False True 10549144.188621497 8227075.080665969 9727024.538474753 1.0 0.7798808067805013 0.9220676449722341 23.330622627607262 -10.724428885267882 5.485592065054012 1.0045876541064787 0.8509742258763681 0.5942677935248114 0.058047533618236925 0.003346027330703199 0.0001680889118230651 0.05774298159481661 0.01873476091598721 1.8861277933348017e-11 10.724428885267882 -0.1536134282301106 IGFPWSEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGFPWSEIR 9 0 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 40883400.0 8176400.0 16091000.0 16616000.0 False True 11199436.038901782 15380046.414178701 12691643.017261874 1.0 1.373287579906289 1.1332394750214956 23.41692274967613 -10.194495040039868 5.4102612925241615 0.9999888940064238 1.253263527463929 0.5974531787753513 0.09799922844844557 1.312924467723004e-05 1.954752537588346e-06 0.09489150446699772 0.031629114976813755 6.39006035222167e-11 10.194495040039868 0.2532746334575052 IGFPWSEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGFPWSEIR 9 0 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 20385800.0 10895000.0 4760700.0 4730100.0 False True 9059675.2303368 4735053.164175038 5719142.040488654 1.0 0.5226515348275911 0.6312745098563584 23.11102790304154 -9.804424199817552 6.299821816358585 1.000000012429791 0.5769630223417967 0.9528819719483006 0.044345143861334 7.700372963280901e-09 1.5234031095523831e-09 0.04293700219432359 0.01431233363823422 1.5688296916258585e-10 9.804424199817552 -0.4230369900879942 IGFPWSEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGFPWSEIR 9 0 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 15202400.0 5249700.0 4454500.0 5498200.0 False True 6795840.137057676 4206603.159179801 4497584.01629609 1.0 0.6189967795506576 0.6618142754375269 22.69622048479705 -10.357167042126529 8.84792236324296 1.0000007380348641 0.6404055277294541 0.9894783435138473 0.017480169497757894 2.544774243202639e-07 1.848510189918223e-08 0.016925136012631275 0.005641700446141598 4.3937258762165037e-11 10.357167042126529 -0.35959521030541 IGFVGFPSVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGFVGFPSVGK 11 0 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 0 12797800.0 3626600.0 3254900.0 5916300.0 False True 4754507.720044353 2769281.6075008274 5304138.029156951 1.0 0.5824539091241593 1.115601938513094 22.18086454203632 -6.697742569867343 1.8384881774690351 0.740162136708898 1.1139752101178917 0.40712735993507854 0.17632338489953045 0.4002047889766861 2.6281503056912547 0.0765515180771706 0.19745235912476744 2.0056605399661365e-07 6.697742569867343 0.3738130734089937 IGFVGFPSVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGFVGFPSVGK 11 0 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 0 9126000.0 2644000.0 1249000.0 5233000.0 False True 2560067.6672524265 1747732.2134489545 3862320.313365077 1.0 0.6826898506650393 1.5086789942198222 21.287750513111682 -6.802564464528352 1.4453953491391043 0.8254912358385875 1.5208194081719622 0.8395617060747045 0.13627108120391368 0.21711731794758463 0.8952170069375477 0.07415981598899257 0.17220796443611425 1.575562136722445e-07 6.802564464528352 0.6953281723333746 IGFVGFPSVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGFVGFPSVGK 11 0 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 0 11489800.0 3626600.0 3849800.0 4013400.0 False True 4967452.025179922 3679703.106413843 3065517.578567571 1.0 0.7407626863352674 0.6171207216553919 22.244074603559213 -13.999999999995042 0.09818122183338193 2.287379220508529 0.3461906422401678 0.9998027933034297 0.00224047020240664 12.094538145859858 0.0929415488073157 3.169799599617822 0.24189891318084528 1.0000000000114158e-14 13.999999999995042 -1.941188578268361 IGFVGFPSVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGFVGFPSVGK 11 0 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 0 5891400.0 2644000.0 1753300.0 1494100.0 False True 2198603.1490601613 1743854.624897197 1806509.4020621292 1.0 0.7931647990419025 0.8216623372136801 21.06815578854596 -10.148525680897954 7.597559485104107 1.0000000653881458 0.8074135681708363 0.9838433748092369 0.011634071241056879 1.288463940383226e-08 1.4360746422867664e-09 0.011264644901980562 0.003754880347100324 7.103531638360693e-11 10.148525680897954 -0.19258649721730947 IGGDAATTVNNSTPDFGFGGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGGDAATTVNNSTPDFGFGGQK 22 0 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 19225400.0 2997600.0 8857400.0 7370400.0 False True 3929882.6287996895 7535910.445874788 6607781.709869065 1.0 1.9175917343303694 1.6814196081696442 21.90605479443471 -10.208307013794249 6.055721864112619 0.9999871681171193 1.7995056712499982 0.9385750978084025 0.09641686676034583 1.671382727461008e-05 2.1851367650492904e-06 0.09335672640327788 0.031118409938024515 6.190033312000498e-11 10.208307013794249 0.7995185031328789 IGGDAATTVNNSTPDFGFGGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGGDAATTVNNSTPDFGFGGQK 22 0 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 19191900.0 5200300.0 2509600.0 11482000.0 False True 5035219.3230003 3511696.36739111 8474519.7473835 1.0 0.6974266942752795 1.6830487817428077 22.26362318952517 -6.824316236361462 1.353286103869097 0.8375917349613097 1.7065893115711481 0.8939829898188407 0.13422993329082084 0.1879347265102571 0.6751138311431828 0.07792350116885956 0.1794111291601449 1.4985932207792036e-07 6.824316236361462 0.8689975766098385 IGGDAATTVNNSTPDFGFGGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGGDAATTVNNSTPDFGFGGQK 22 0 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 19235300.0 2997600.0 10410000.0 5827700.0 False True 4105893.7270940645 9950051.778733479 4451317.285248978 1.0 2.423358333186963 1.0841287137744273 21.9692648559576 -6.631857317895398 2.0742811931188467 1.9364790556867342 1.0896106445848208 0.1240723764699806 0.6102633173244407 0.5541378936541063 4.546275483644608 0.24046095539004725 0.6757446474995644 2.3342248171427513e-07 6.631857317895398 -0.8468684111019134 IGGDAATTVNNSTPDFGFGGQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGGDAATTVNNSTPDFGFGGQKR 23 1 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 1 11282600.0 3497200.0 6078400.0 1707000.0 True False 4584863.066932971 5171526.413417623 1530376.01470022 1.0 1.1279565688048125 0.3337888160145119 22.128447215771157 -6.8656115587647815 1.156981920442963 1.0707696169166947 0.2909838694466549 0.9601078245019331 0.06953726290349001 0.14113624449724022 0.3558549235049469 0.04675596952291859 0.10993428969404806 1.3626629291845798e-07 6.8656115587647815 -0.7797857474700398 down IGGDAATTVNNSTPDFGFGGQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGGDAATTVNNSTPDFGFGGQKR 23 1 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 1 18732700.0 8242700.0 6362100.0 4127900.0 True False 7981040.000325866 8902519.707913209 3046679.155654449 1.0 1.1154586003264886 0.38173961733433903 22.92814532398614 -6.866669512086813 1.1516571180352209 1.0641451120226324 0.3414197738562388 0.9612398503655628 0.06342001427632793 0.14008340905075614 0.34935292688414954 0.042820470782343314 0.10082669838339625 1.3593474846465778e-07 6.866669512086813 -0.7227253381663936 down IGGDAATTVNNSTPDFGFGGQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGGDAATTVNNSTPDFGFGGQKR 23 1 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 1 19083800.0 8242700.0 7566700.0 3274400.0 True False 6854170.263524282 7525936.685227654 3959061.90088498 1.0 1.0980084234671408 0.5776135912400441 22.708550599420416 -6.8579895798142285 1.19584672296642 1.0529168875279566 0.5533633702925115 0.9511510746520746 0.04990345285024747 0.1488863555393884 0.4057270900855233 0.03257338521953293 0.07587242038978848 1.3867891022090252e-07 6.8579895798142285 -0.49955351723544517 IGGDAGTSLNSNDYGYGGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGGDAGTSLNSNDYGYGGQK 20 0 Q96AE4;E9PEB5;Q96AE4-2;C9JSZ1 Q96AE4;Q96AE4-2 FUBP1 Far upstream element-binding protein 1 0 10875900.0 1626800.0 4445000.0 4804100.0 False True 2132750.5539536104 3781823.3264742945 4307017.816181209 1.0 1.773214087068784 2.0194662747582113 21.02428380756773 -10.722517267162862 0.2335373080133129 3.24428045304736e-13 2.1641384897128697 0.9992378769419523 0.011990464297966583 2.5218885189583298 0.12104130309910478 1.540021270897851 0.12308050721096502 1.8944481912817665e-11 10.722517267162862 2.164138489712545 IGGDAGTSLNSNDYGYGGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGGDAGTSLNSNDYGYGGQK 20 0 Q96AE4;E9PEB5;Q96AE4-2;C9JSZ1 Q96AE4;Q96AE4-2 FUBP1 Far upstream element-binding protein 1 0 12738200.0 5182500.0 1364800.0 6190900.0 False True 5017984.374257075 1909771.7573379762 4569317.566981056 1.0 0.38058543329376604 0.9105882414505435 22.258676547600768 -10.308162367062932 8.202454726287757 1.0000007494505467 0.6455868373721688 0.37351753803993815 0.21637274037105114 2.96551612520116e-06 2.5005276659400723e-07 0.20950244826485687 0.06983400166919519 4.9185561420591237e-11 10.308162367062932 -0.3544139120783779 IGGDAGTSLNSNDYGYGGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGGDAGTSLNSNDYGYGGQK 20 0 Q96AE4;E9PEB5;Q96AE4-2;C9JSZ1 Q96AE4;Q96AE4-2 FUBP1 Far upstream element-binding protein 1 0 12423200.0 1626800.0 4555700.0 6240700.0 False True 2228271.922616971 4354414.110314702 4766775.19125097 1.0 1.954166395096297 2.139225084186619 21.087493869090622 -10.774614862358378 0.32185446259315026 1.9497275453820716e-10 2.184232181799076 0.9992087145257036 0.01404148009952962 2.4650537086034072 0.15948076894035498 1.9616983249569513 0.06087477428943915 1.6802934623254232e-11 10.774614862358378 2.184232181604103 IGGDAGTSLNSNDYGYGGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGGDAGTSLNSNDYGYGGQK 20 0 Q96AE4;E9PEB5;Q96AE4-2;C9JSZ1 Q96AE4;Q96AE4-2 FUBP1 Far upstream element-binding protein 1 0 6130440.0 5182500.0 0.0 947940.0 False True 4309478.37367787 0.0 1146149.8712206527 1.0 0.0 0.2659602327328738 22.039081823035044 -10.229975649679503 4.9089179001027015 1.000143661493817 0.13298011636544493 0.9340795132501921 0.10857781034865166 612417306.3058162 254.5244526324018 996074.5390316647 0.03716907248217131 5.88876671970598e-11 10.229975649679503 -0.8671635451283721 IGGGIDVPVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGGGIDVPVPR 11 0 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 37096000.0 10557000.0 10443000.0 16096000.0 False True 13840329.234133413 8884945.106495166 14430540.323734485 1.0 0.6419605311543357 1.0426442954944652 23.72237492646378 -6.67109824376384 1.9335961151496255 0.7716805434206331 1.0410289654723752 0.2838956477635316 0.15204898555567836 0.4585850587854922 3.306581051538713 0.06328402452594961 0.16883013775211986 2.132562441762199e-07 6.67109824376384 0.26934842205174214 IGGGIDVPVPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGGGIDVPVPR 11 0 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 19861900.0 5459900.0 2485000.0 11917000.0 False True 5286578.46309816 3477273.459103801 8795580.197663223 1.0 0.657755007965203 1.663756673443685 22.333902864183138 -6.81491904493421 1.393841739420697 0.8145304427346399 1.6833909779046745 0.8722523012516126 0.1492690231649129 0.20017772596055367 0.7655181098694533 0.08418548170742084 0.19433343040034068 1.5313728920628317e-07 6.81491904493421 0.8688605351700346 IGGGIDVPVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGGGIDVPVPR 11 0 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 28504000.0 10557000.0 8260700.0 9686300.0 False True 14460208.192197772 7895714.95951811 7398595.4356104685 1.0 0.5460305173046102 0.5116520687165829 23.78558498798667 -13.999999999999998 0.3660524926252782 7.168726847560532 0.5078648484449314 0.9997840665876422 0.0032702846374153033 22.365574993691467 0.19603539735778333 108.07488709968992 0.00972853477021335 1.0000000000000041e-14 13.999999999999998 -6.660861999115601 IGGGIDVPVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGGGIDVPVPR 11 0 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 11591900.0 5459900.0 3546100.0 2585900.0 False True 4540148.764581537 3526996.45545426 3126599.7341493005 1.0 0.7768460106349272 0.6886557899909427 22.114308139617414 -13.999999999999998 0.12820653061958898 2.060368336341287 0.5622915698308466 0.9996538080224627 0.0024378946558870724 11.939837586809862 0.11116664585502198 3.195739009322598 0.11231002168237823 1.0000000000000041e-14 13.999999999999998 -1.4980767665104402 IGGIFAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGGIFAFK 8 0 P22307-7;P22307-8;P22307;P22307-6;P22307-2;P22307-4;H0YF61 P22307-7 SCP2 Non-specific lipid-transfer protein 0 92674000.0 26993000.0 26982000.0 38699000.0 False True 35388084.40058382 22956390.775012232 34694798.707020424 1.0 0.6487039681253136 0.980409064087347 25.07676033327686 -10.568093656851582 8.995217881640812 1.0000241612786216 0.8145565165308816 0.2941505595168695 0.13541803836465174 6.562460897225773e-05 3.151058381117698e-06 0.13113500204207132 0.043705983946864424 2.7033753105972665e-11 10.568093656851582 -0.18546764474774002 IGGIFAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGGIFAFK 8 0 P22307-7;P22307-8;P22307;P22307-6;P22307-2;P22307-4;H0YF61 P22307-7 SCP2 Non-specific lipid-transfer protein 0 77106000.0 24753000.0 10585000.0 41768000.0 False True 23967229.564107187 14811645.700045789 30827707.78685891 1.0 0.6179957370720642 1.2862441069545154 24.514559817874403 -6.751653640460565 1.643618101199007 0.7758238771278773 1.2877494131955785 0.656079033918341 0.16053617632883865 0.29718015816082505 1.5800353188452707 0.07713899037118348 0.18695648056163774 1.7715212227882749e-07 6.751653640460565 0.5119255360677012 IGGIFAFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGGIFAFK 8 0 P22307-7;P22307-8;P22307;P22307-6;P22307-2;P22307-4;H0YF61 P22307-7 SCP2 Non-specific lipid-transfer protein 0 35856300.0 9595300.0 12383000.0 13878000.0 False True 14556771.610393593 10173156.901179396 11135007.217056518 1.0 0.6988607895665355 0.7649365886256042 23.795187095427096 -10.0924266454511 5.053672289341128 1.0000069457704897 0.7318986890952311 0.9564286675810939 0.026975332009814574 2.1111163991213543e-06 3.79078877268902e-07 0.026119429562892107 0.008706250968951066 8.083014438119596e-11 10.0924266454511 -0.2681082566752585 IGGIFAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGGIFAFK 8 0 P22307-7;P22307-8;P22307;P22307-6;P22307-2;P22307-4;H0YF61 P22307-7 SCP2 Non-specific lipid-transfer protein 0 75121000.0 26993000.0 18621000.0 29507000.0 False True 36973041.558396764 17798262.64858752 22538054.31574063 1.0 0.4813848657940733 0.6095807476413074 25.13997039479975 -10.105599694793453 7.6681872758750185 1.0000000629682002 0.5454828067177493 0.9436957982026747 0.0523357496086407 5.637693806660145e-08 6.597606684229901e-09 0.050673879212319146 0.016891290553795568 7.841520916018246e-11 10.105599694793453 -0.4545172562504509 IGGIFAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGGIFAFK 8 0 P22307-7;P22307-8;P22307;P22307-6;P22307-2;P22307-4;H0YF61 P22307-7 SCP2 Non-specific lipid-transfer protein 0 50176000.0 24753000.0 12057000.0 13366000.0 False True 20583216.2438299 11992046.547872866 16160768.802598534 1.0 0.5826128631120827 0.7851430316407887 24.29496509330868 -10.113889324481605 4.999152316816604 1.0000117503936792 0.6838779473754286 0.7646170069524431 0.08268259507269482 1.0828825348814914e-05 1.9193175576270725e-06 0.080060053397902 0.026685692810980197 7.69326470310341e-11 10.113889324481605 -0.31613380301825056 IGGIFAFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGGIFAFK 8 0 P22307-7;P22307-8;P22307;P22307-6;P22307-2;P22307-4;H0YF61 P22307-7 SCP2 Non-specific lipid-transfer protein 0 56787300.0 9595300.0 28440000.0 18752000.0 False True 12421305.001640007 26857288.999230742 15339328.41176824 1.0 2.1621954372495265 1.2349208404224001 23.566313417519545 -10.088714864495884 4.167849205226322 0.9998950745995888 1.698558137685087 0.4307527530291141 0.3785582695245778 265295624.0804667 978749557.595453 510699.9114491257 0.13853820592138177 8.152393527394389e-11 10.088714864495884 0.6986630630854981 IGGIGTVPVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGGIGTVPVGR 11 0 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 0 607576000.0 37176000.0 300680000.0 269720000.0 False True 48738096.01289606 255819716.0414604 241811961.73693204 1.0 5.248865609640776 4.961456879089999 25.538546556503682 -10.193114706540651 4.521573406218975 0.9990817338999168 5.105161244353901 0.9963372514352393 0.11733412313975065 20606917.897742767 339.1708564586839 197904.74748875105 0.0401665912211909 6.410402416682142e-11 10.193114706540651 4.106079510453984 IGGIGTVPVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGGIGTVPVGR 11 0 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 0 557752000.0 141880000.0 74392000.0 341480000.0 False True 137376097.06118542 104097113.54915494 252036143.81958845 1.0 0.7577527370193923 1.834643356531923 27.03355576142654 -6.847643098767705 1.2465735527175255 0.8709523443266984 1.875736145546468 0.9367805017888289 0.11598168476577567 0.16007148729934345 0.4798787114532018 0.07284985439633847 0.168328375686567 1.4202241760238146e-07 6.847643098767705 1.0047838012197696 IGGIGTVPVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGGIGTVPVGR 11 0 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 0 2591793000.0 36193000.0 2522900000.0 32700000.0 False True 54907427.062726006 2072668783.4923298 26236830.667080868 1.0 37.748423016152664 0.4778375544187861 25.710497973038517 -3.3255215458993703 19.574289546762998 9.999999999999998 18.984421097300675 0.0 17.71672051597387 0.0 0.0 5.959194994905575 0.0 0.0004725833908561056 3.3255215458993703 8.984421097300677 IGGIGTVPVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGGIGTVPVGR 11 0 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 0 809666000.0 37176000.0 277000000.0 495490000.0 False True 50920971.84362454 264761224.08349407 378465466.9368728 1.0 5.199453476586444 7.4324085584839015 25.601756618026574 -8.57557658458298 0.34308315446234444 8.66810740122056e-23 8.258464001650513 0.9980354671992415 0.11819237965594581 0.2148434330994753 0.1036312116176622 0.8818185325144374 0.6375848827092747 2.657194931788839e-09 8.57557658458298 8.258464001650513 IGGIGTVPVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGGIGTVPVGR 11 0 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 0 172507000.0 141880000.0 13428000.0 17199000.0 False True 117979506.34971847 13355660.698750695 20795231.380808927 1.0 0.11320322581416332 0.17626138661037508 26.813961036860817 -10.204446370847446 5.097464159926721 1.0000753001693399 0.14473230621168773 0.9959395633959498 0.025743386346871754 2.2032066605810404e-05 3.438505492653775e-06 0.024928101491992875 0.008308642216077848 6.245304660928503e-11 10.204446370847446 -0.8553429939576521 IGGIGTVPVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGGIGTVPVGR 11 0 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 0 138273000.0 36193000.0 52901000.0 49179000.0 False True 46852551.970689446 49957012.84628364 40228926.61915268 1.0 1.0662602301265536 0.8586282908200934 25.481624295130967 -6.8208427600434565 1.3681218617485595 1.03568373786438 0.8540090114408659 0.8863388939304448 0.029194162882372258 0.19238320668420028 0.7073201320793785 0.016767303283318827 0.03863945968996656 1.5106269903257088e-07 6.8208427600434565 -0.181674726423514 IGGK(ub)SPDTNYLFMGDYVDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGGKSPDTNYLFMGDYVDR 19 1 P67775;P67775-2;E7ESG8;E5RFI3;E5RHP4;E5RHC1;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 30456200.0 10172000.0 7351200.0 12933000.0 True False 9849095.427871287 10286572.49600157 9545459.318316558 1.0 1.0444179946609407 0.9691711678723826 23.231559798294096 -6.746749750341004 1.6617251398242636 1.026220194101285 0.969056769347377 0.6348896011859764 0.01866262028762542 0.3057688573097245 1.6601439807841727 0.008875536186613547 0.021622698567827673 1.7916379362968955e-07 6.746749750341004 -0.05716342475390801 IGGK(ub)SPDTNYLFMGDYVDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGGKSPDTNYLFMGDYVDR 19 1 P67775;P67775-2;E7ESG8;E5RFI3;E5RHP4;E5RHC1;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 64402000.0 11292000.0 18663000.0 34447000.0 True False 17130789.555778787 15332441.835315432 27638535.351343554 1.0 0.8950224848301455 1.6133836249258082 24.030088310785576 -6.869771230056833 1.13524957564814 0.9407047475708039 1.655281932117231 0.9644572083180427 0.05972705649539026 0.13707731963683484 0.330320770930736 0.0408348611890633 0.09664404593080823 1.349673652516456e-07 6.869771230056833 0.714577184546427 IGGK(ub)SPDTNYLFMGDYVDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGGKSPDTNYLFMGDYVDR 19 1 P67775;P67775-2;E7ESG8;E5RFI3;E5RHP4;E5RHC1;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 26187900.0 10172000.0 7698900.0 8317000.0 True False 8458468.696006035 7657424.497588003 10056046.24653688 1.0 0.9052967827620768 1.1888731409841593 23.011965073728373 -6.816649893796376 1.3861930785274836 0.9487757831620262 1.194635841513952 0.8765307350174601 0.04142025046622538 0.19786950758751343 0.7479642619731404 0.0234855888918531 0.05418774980277013 1.5252818632529974e-07 6.816649893796376 0.24586005835192581 IGGK(ub)SPDTNYLFMGDYVDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGGKSPDTNYLFMGDYVDR 19 1 P67775;P67775-2;E7ESG8;E5RFI3;E5RHP4;E5RHC1;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 1 59085000.0 11292000.0 12712000.0 35081000.0 True False 14617716.5985971 12004566.025253912 28696617.961457055 1.0 0.821234010406661 1.9631395757262897 23.801214632878025 -6.8668945354333175 1.1504822878284027 0.900578144641615 2.0261601377072767 0.9614797027130438 0.0984278449757052 0.13986260057871108 0.34795517634548295 0.06651714958166359 0.15667768805077592 1.3586433410261034e-07 6.8668945354333175 1.1255819930656616 IGGLFIYNHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGGLFIYNHK 10 0 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2;C9JJ47;C9JTK4;C9JGT8;C9JJD3;C9JPV8 E9PFW3 AP2M1 AP-2 complex subunit mu 0 9259900.0 2578500.0 2387200.0 4294200.0 False True 3380438.470229521 2031039.065232721 3849877.3768750387 1.0 0.6008211902448323 1.138869235686353 21.688778957192177 -6.707986102271215 1.8021488836209603 0.7540964748524941 1.1375453876598958 0.45566126382036143 0.1682650268018035 0.37912654794759276 2.398894031487239 0.07433409486383406 0.18932274808881547 1.9589073589158432e-07 6.707986102271215 0.3834489128074017 IGGLFIYNHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGGLFIYNHK 10 0 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2;C9JJ47;C9JTK4;C9JGT8;C9JJD3;C9JPV8 E9PFW3 AP2M1 AP-2 complex subunit mu 0 8930500.0 2784000.0 1617800.0 4528700.0 False True 2695623.443884555 2263795.976715546 3342497.6119121774 1.0 0.8398042322459106 1.239972007030566 21.36218754745272 -6.798095162461456 1.4639950342738584 0.9113978492883361 1.245219705994639 0.8264389183991705 0.06850944994511504 0.22349369514825668 0.945919290702009 0.03682036402246324 0.08571980892975295 1.59185988102894e-07 6.798095162461456 0.33382185670630293 IGGLFIYNHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGGLFIYNHK 10 0 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2;C9JJ47;C9JTK4;C9JGT8;C9JJD3;C9JPV8 E9PFW3 AP2M1 AP-2 complex subunit mu 0 7853300.0 2578500.0 2128500.0 3146300.0 False True 3531841.131342427 2034455.8319917563 2403208.740082514 1.0 0.5760326572839007 0.6804407816523367 21.75198901871507 -9.924893248243485 6.714340452463956 1.0000000224715866 0.6282367194681204 0.9441482156605957 0.04262443828397045 1.4344638965442423e-08 2.198226070360605e-09 0.04127093736374223 0.01375697830126928 1.1887944031384922e-10 9.924893248243485 -0.37176330300346616 IGGSTDTGK(ub)HIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGGSTDTGKHIK 12 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 39752000.0 4226400.0 5995600.0 29530000.0 True False 5540851.328515821 5101079.850665756 26474518.871761866 1.0 0.9206310633915054 4.778059778559943 22.401676226657962 -6.902202795606249 0.947229652662644 0.8491709651737869 5.201584833286603 0.9876309178828288 0.20018875931005803 0.1098021978906106 0.16841316234492523 0.15782503220715322 0.4153668528334343 1.2525561520819834e-07 6.902202795606249 4.352413868112816 up IGGSTDTGK(ub)HIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGGSTDTGKHIK 12 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 41117400.0 3106900.0 6679500.0 31331000.0 True False 3008273.160131076 9346659.183132345 23124471.1901474 1.0 3.1069848666020388 7.686958583621384 21.520504143279155 -6.958383685949896 0.4576438877328164 0.8633143636176314 10.114529079286445 0.9997054765129497 0.04790640697642598 0.08028362520828372 0.023303408661122404 0.06195604787108525 0.3784533383711092 1.1005665628641288e-07 6.958383685949896 9.251214715668814 IGGSTDTGK(ub)HIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGGSTDTGKHIK 12 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 65199800.0 1804800.0 18961000.0 44434000.0 True False 2738013.548553803 15577261.407030838 35651600.423885986 1.0 5.689256510530645 13.020972976089501 21.384698154847314 -6.964558899949016 0.3655444733344277 0.40692289502693846 18.556736296126537 0.9999037609542069 0.0485298983475051 0.07811097062381346 0.015389728283624277 0.09734277954927352 0.6242068712617729 1.0850283857770554e-07 6.964558899949016 18.1498134010996 IGGSTDTGK(ub)HIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGGSTDTGKHIK 12 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 45655200.0 4226400.0 3800800.0 37628000.0 True False 5789014.294165457 3632868.088435175 28741041.372985672 1.0 0.6275451922957963 4.964755641034218 22.464886288180853 -6.886006086580078 1.0456854541004537 0.7441602586305759 5.309909696043684 0.9782177261993953 0.28967001490953825 0.1224449490009191 0.2412386679762107 0.21209350439433974 0.5217104612322483 1.300151356455241e-07 6.886006086580078 4.565749437413109 up IGGSTDTGK(ub)HIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGGSTDTGKHIK 12 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 32679100.0 3106900.0 7968200.0 21604000.0 True False 2583525.0090071918 7925273.725036137 26121296.514390096 1.0 3.067620285232577 10.11071943306951 21.30090941871343 -6.948565453051847 0.574376750021208 0.9139151965601583 12.609438778432237 0.9990838467720924 0.11804335341074154 0.0840669469978914 0.03838613864757534 0.12444431964130193 0.5874743781334856 1.1257307958461521e-07 6.948565453051847 11.695523581872079 IGGSTDTGK(ub)HIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGGSTDTGKHIK 12 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 40272700.0 1804800.0 9403900.0 29064000.0 True False 2336349.177926677 8880564.698307525 23774650.221823383 1.0 3.8010434322956455 10.175983301828833 21.155824476939763 -6.957441033566576 0.47011124804057636 0.8318021802448102 13.406615249517486 0.9996632039452391 0.070464784575341 0.08062820973322037 0.0246071840381665 0.08816235810511855 0.5261546772541982 1.1029579780573445e-07 6.957441033566576 12.574813069272675 IGGTAIQLNVFQYLTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGGTAIQLNVFQYLTR 16 0 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 0 42146300.0 8190300.0 14949000.0 19007000.0 False True 12425283.891134871 12281234.152929883 15250258.11893594 1.0 0.9884067245893864 1.2273569161519615 23.566775478868596 -6.895499792842893 0.9892884487340279 0.9888018703612586 1.2502666671017428 0.9841909925297407 0.013832170700967756 0.114793779998931 0.19669294028509 0.010568991382721245 0.026927311780740558 1.272038356843857e-07 6.895499792842893 0.2614647967404843 IGGTAIQLNVFQYLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGGTAIQLNVFQYLTR 16 0 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 0 25192700.0 8190300.0 10343000.0 6659400.0 False True 10602504.804949503 9767402.957772298 5447457.531214239 1.0 0.9212354191259258 0.5137896781401349 23.337901800961045 -6.939049400210011 0.6683475535944033 1.0046571467955732 0.40692010407049717 0.9980367356324819 0.009441172573861081 0.08820296791375416 0.0566044752975601 0.009125392484307607 0.03521745556407372 1.1506694949310282e-07 6.939049400210011 -0.597737042725076 IGGVIQDTLPVQNYKTK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGGVIQDTLPVQNYKTK 17 1 C4B7M2;Q96JI7-2;Q96JI7-3;Q96JI7 C4B7M2 SPG11 Spatacsin 1 15687200.0 2479300.0 3600900.0 9607000.0 True False 3209502.7243094053 3400506.7495545 7858624.576144276 1.0 1.0595120308820405 2.4485489657389934 21.613918354912347 -6.915891264931009 0.8546379489815323 0.9645834684883922 2.652666811277933 0.992961534502651 0.05614849345973214 0.1006501435603277 0.11858520894698148 0.04735310392652137 0.1367233794701686 1.2136926867880466e-07 6.915891264931009 1.6880833427895405 up IGGVQQDTILAEGLHFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGGVQQDTILAEGLHFR 17 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5H3X6;F5H2D2;F5H0C5 Q99623 PHB2 Prohibitin-2 0 30978700.0 3880700.0 15191000.0 11907000.0 False True 5087635.280752262 12924562.014054202 10674977.860009084 1.0 2.540386898988397 2.0982199530683876 22.278563820624555 -10.56536564090733 5.5545255436081 0.9949165677431292 2.319303426028393 0.9223007225797184 0.18051389977147422 0.011359097581729111 0.0008888333687937367 0.17471238612542103 0.05826061063115576 2.7204099779842683e-11 10.56536564090733 1.3243868582852638 IGGVQQDTILAEGLHFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGGVQQDTILAEGLHFR 17 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5H3X6;F5H2D2;F5H0C5 Q99623 PHB2 Prohibitin-2 0 34950700.0 11418000.0 7755700.0 15777000.0 False True 11055541.83989721 10852591.455441192 11644530.4001454 1.0 0.981642656018576 1.0532754132522615 23.39826639859917 -6.838738088097414 1.2884363462275539 0.9902325904571598 1.055570376011354 0.9222285780097907 0.008472236364988998 0.1702810270758521 0.5496807987743918 0.005157453355952361 0.011876783198660432 1.4496458343340023e-07 6.838738088097414 0.06533778555419412 IGGVQQDTILAEGLHFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGGVQQDTILAEGLHFR 17 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5H3X6;F5H2D2;F5H0C5 Q99623 PHB2 Prohibitin-2 0 29880700.0 3880700.0 11426000.0 14574000.0 False True 5315499.661974234 10921161.539270766 11131921.360951751 1.0 2.054587947281428 2.0942379962107336 22.341773882147447 -10.935118504397499 0.5764391449155915 2.7968765825061414e-11 2.090086006864909 0.9998849341881916 0.005435751325793156 2.721883790801905 0.28279354593790984 3.6609911784689375 0.007117258080551406 1.1611317367041535e-11 10.935118504397499 2.0900860068369402 IGHIAHLNLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGHIAHLNLR 10 0 Q32P41 Q32P41 TRMT5 tRNA (guanine(37)-N1)-methyltransferase 0 4938100.0 1180700.0 1757600.0 1999800.0 False True 1547909.1339150635 1495372.9310711387 1792879.8794361437 1.0 0.9660598922166399 1.158259125263694 20.561889353534042 -6.861283857005598 1.1791302730623372 0.9815171505655306 1.1678016641222735 0.9551883071644097 0.017730512001905015 0.14549067852612782 0.3836329732279231 0.011721233350993976 0.027403474432160343 1.376309612130919e-07 6.861283857005598 0.18628451355674291 IGHIAHLNLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGHIAHLNLR 10 0 Q32P41 Q32P41 TRMT5 tRNA (guanine(37)-N1)-methyltransferase 0 4500300.0 1180700.0 1374400.0 1945200.0 False True 1617236.6972177618 1313674.463466984 1485783.8226515271 1.0 0.8122957299491065 0.9187176034328298 20.625099415056933 -10.210084764456822 4.704960573654204 1.000025833345783 0.8655066666903283 0.6804605374093013 0.04344654791988614 1.1775441795828482e-05 1.9769733723143693e-06 0.04207501597013403 0.014022313045015998 6.16474668211355e-11 10.210084764456822 -0.1345191666554547 IGHIAHLNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGHIAHLNLR 10 0 Q32P41 Q32P41 TRMT5 tRNA (guanine(37)-N1)-methyltransferase 0 2082370.0 1179700.0 902670.0 0.0 False True 980972.8195712074 897807.1375440334 0.0 1.0 0.915221216767732 0.0 19.903853637779314 -7.100144423342307 0.9900845251855065 1.0007488819099413 5.6755018619079134e-18 0.9894486921272981 0.046505955641540156 0.08471643693319238 0.1579858060364207 0.03832142997134377 0.06771621813391458 7.940641271414767e-08 7.100144423342307 -1.0007488819099413 down IGHK(ub)VESESYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGHKVESESYR 11 1 A0A0C4DGY8;D6RA00;Q9UHY7;Q9UHY7-2 A0A0C4DGY8 ENOPH1 Enolase-phosphatase E1 1 1910190.0 527700.0 699930.0 682560.0 True False 438805.93107377004 696159.338164773 825280.1401991345 1.0 1.586485707841852 1.8807406230349977 18.743223500344023 -10.23097418466401 0.15026263019831446 4.521624490982004e-25 2.307423313052708 0.9997070845562995 0.006265696386698542 1.9045581963988305 0.07435846279963836 0.9912813843169026 0.26349363303458934 5.875242751143885e-11 10.23097418466401 2.307423313052708 IGHPAPNFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGHPAPNFK 9 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 23073500.0 1213500.0 10150000.0 11710000.0 False True 1590910.251550718 8635659.564390114 10498361.53025167 1.0 5.428124908977501 6.598965290479797 20.601421020144095 -9.313915767653704 0.4392434018891996 4.893855080691658e-23 6.694468823904007 0.9979194844244323 0.10998400063474469 0.6834729662452641 0.17731085960751006 1.468509352253401 0.2674736947823242 4.853826320358814e-10 9.313915767653704 6.694468823904007 IGHPAPNFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGHPAPNFK 9 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 28997600.0 6237800.0 2259800.0 20500000.0 False True 6039784.453399093 3162149.924701322 15130435.01318254 1.0 0.5235534395472864 2.5051283087871417 22.526065633185617 -6.84321983633947 1.267328493366785 0.7465440819289008 2.5745804513074066 0.9298500589039517 0.22368034863029188 0.16507534245415711 0.513617496010081 0.1383161414557711 0.31898818879420077 1.4347629841381626e-07 6.84321983633947 1.828036369378506 up IGHPAPNFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGHPAPNFK 9 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 83994800.0 1349800.0 80888000.0 1757000.0 False True 2047745.2835981438 66452904.4191714 1409728.1798795443 1.0 32.45174336448983 0.6884294600363948 20.96560484084182 -3.0466481959067675 16.190646331778705 9.999999999999925 14.740674505997829 0.0 14.96424768156457 0.0 0.0 4.856860564341329 0.0 0.0008981560591714357 3.0466481959067675 4.740674505997903 IGHPAPNFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGHPAPNFK 9 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 24587500.0 1213500.0 11284000.0 12090000.0 False True 1662163.7436044358 10785435.56880197 9234591.001365906 1.0 6.488792461212957 5.555764909984444 20.664631081666986 -9.840928426224588 6.946188616094303 0.9999999579286344 6.022278685598793 0.9747681035577691 0.380906902745059 2.6359096434607214e-07 4.430635759229807e-08 0.3688115226964232 0.12293717423220558 1.4423530385101597e-10 9.840928426224588 5.022278727670159 IGHPAPNFK(ub)ATAVMPDGQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGHPAPNFKATAVMPDGQFK 20 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 10174400.0 2130700.0 3285200.0 4758500.0 True False 2918477.370002447 3140049.001296373 3634640.304383759 1.0 1.0759202841767248 1.2453892367788726 21.47678445086904 -6.957841288901524 0.46486020619793367 0.9952928741745118 1.3329042198157057 0.9996815600420785 0.0018304766426282604 0.08048147338850271 0.024050349159681447 0.0023211878002943626 0.013993033657275918 1.1019419360306244e-07 6.957841288901524 0.3376113456411939 IGHPAPNFK(ub)ATAVMPDGQFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGHPAPNFKATAVMPDGQFK 20 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 7037600.0 1992900.0 3312100.0 1732600.0 True False 1657184.650439484 3294257.0598996216 2094878.649362728 1.0 1.9878636089381996 1.264119027899014 20.660302931950774 -10.13422822349523 4.49678668962859 0.9999397727862981 1.625991318235098 0.49936949795245134 0.29546748822801155 207999303.02416515 122093491.22743848 185865.25282141028 0.10813003189311339 7.341279795700132e-11 10.13422822349523 0.6260515454487999 IGHPAPNFK(ub)ATAVMPDGQFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGHPAPNFKATAVMPDGQFK 20 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 25181700.0 5959100.0 10300000.0 8922600.0 True False 7714172.421422243 9726795.945572319 7298778.35360727 1.0 1.2608994736183265 0.9461518300185481 22.879079961693602 -6.686648076906586 1.8785194576900672 1.16408307628976 0.9472881447593393 0.35465087862910183 0.11041912435686954 0.4239400037956122 2.8978616182126835 0.04707160244731798 0.12308941482301497 2.057557226880374e-07 6.686648076906586 -0.21679493153042073 IGIEIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGIEIIK 7 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 366540000.0 127160000.0 104050000.0 135330000.0 False True 166707991.41919166 88526145.58372338 121327349.77702445 1.0 0.5310252065908588 0.7277836457878232 27.312748023018298 -10.225813183631177 5.504843822075058 1.0000202825574518 0.6294044261893171 0.8254836825612977 0.08032629643658316 1.999636811863429e-05 2.8121754517328897e-06 0.0777798538189261 0.025925200696771632 5.945478546700057e-11 10.225813183631177 -0.37061585636813466 IGIEIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGIEIIK 7 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 281212000.0 106930000.0 43602000.0 130680000.0 False True 103535565.68052275 61012505.98142616 96450987.68403381 1.0 0.589290313723605 0.9315734844357768 26.625551194620982 -10.021718938715331 7.0031241123343895 1.0000000337602226 0.7604318990796908 0.39510119873946425 0.13973651929779543 7.362997509493244e-08 1.0363977618041045e-08 0.1352993211693497 0.04509976767477932 9.512201933190354e-11 10.021718938715331 -0.23956813468053184 IGIEIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGIEIIK 7 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 257391000.0 33449000.0 179760000.0 44182000.0 False True 50744578.44945494 147680423.5287095 35449408.334341444 1.0 2.9102699843257005 0.6985851379108701 25.596750357210777 -6.678210713310504 1.9081105706001273 2.21057943885921 0.707091652147145 0.3160009530714193 0.8099355113383728 0.44251735519265656 3.113401649828718 0.3407830381185278 0.9009021568259463 2.0979217557986595e-07 6.678210713310504 -1.503487786712065 IGIEIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGIEIIK 7 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 400460000.0 127160000.0 99430000.0 173870000.0 False True 174174488.36978972 95036853.82895967 132805486.96505284 1.0 0.5456416420020538 0.7624852997018348 27.37595808454119 -10.066000672695418 5.011705593043155 1.0000072121826498 0.6540634708501434 0.7723870975125222 0.08852605256011468 7.133929928735836e-06 1.3296282733295997e-06 0.08571676810370535 0.02857166060500629 8.590121909473602e-11 10.066000672695418 -0.3459437413325064 IGIEIIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGIEIIK 7 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 200043000.0 106930000.0 49318000.0 43795000.0 False True 88917032.80219485 49052314.14514346 52952332.01479889 1.0 0.5516638668573817 0.5955251805646375 26.40595647005526 -10.11899672555979 7.89089553938342 1.0000000476341009 0.573594524266561 0.992126891203151 0.01790630633848642 1.501245555464994e-08 1.6697665084378058e-09 0.01733770862706426 0.005779235520087194 7.603320095765009e-11 10.11899672555979 -0.4264055233675399 IGIEIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGIEIIK 7 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 136660000.0 33449000.0 68991000.0 34220000.0 False True 43300389.87836299 65151590.20203699 27992311.126850974 1.0 1.5046421148875833 0.6464678772058495 25.367876679303226 -6.747372168202772 1.659868285851996 1.2976719715770009 0.6451283504522102 0.6374795173538319 0.21203074546348719 0.3046429862333167 1.6506174973524563 0.10095114157056612 0.24573347877392931 1.789072053506693e-07 6.747372168202772 -0.6525436211247907 IGIIDGEYVVNPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGIIDGEYVVNPTR 14 0 Q8TCS8 Q8TCS8 PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial 0 2386130.0 670930.0 1715200.0 0.0 False True 879595.7272953623 1459298.845797235 0.0 1.0 1.6590563147508472 0.0 19.746481070643377 -6.8127959042138055 1.49488188143016 1.363281601586338 1.8867422699035838e-18 0.8284476230170801 0.28250062957540156 0.21412456192913717 0.9570663060428946 0.1506373537596007 0.33394121119024184 1.5388776627470761e-07 6.8127959042138055 -1.363281601586338 IGIIDGEYVVNPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGIIDGEYVVNPTR 14 0 Q8TCS8 Q8TCS8 PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial 0 4398430.0 670930.0 1595000.0 2132500.0 False True 918990.9522015022 1524527.6260403364 1628847.4202161145 1.0 1.6589147285816384 1.7724303120875187 19.809691132166268 -11.31055947653394 0.31181993354900206 8.966508593104109e-26 1.8010722685489646 0.9993582852245426 0.008626569633702496 3.4822130129682187 0.16268383411573423 2.432839907399494 0.03894797691714192 4.8914827179873825e-12 11.31055947653394 1.8010722685489646 IGK(ub)FEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGKFEAR 7 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 80695200.0 22869000.0 51371000.0 6455200.0 True False 19016586.768478382 51094254.2266549 7804952.474527451 1.0 2.686825708983065 0.41042867311313863 24.180754988533934 -6.708188469219586 1.801441641652537 2.0388758888008587 0.41596755312302464 0.45672947480602977 0.7110140066205111 0.37865247311156547 2.394145303751071 0.314214426199668 0.800076750667528 1.9579947851293394e-07 6.708188469219586 -1.622908335677834 IGK(ub)VDCTQHYELCSGNQVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGKVDCTQHYELCSGNQVR 19 1 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 1 7016950.0 992950.0 1382500.0 4641500.0 True False 1301767.0657414787 1176236.388942792 4161242.104411877 1.0 0.9035690177588068 3.1966103721034442 20.31203988943756 -6.897080708241066 0.9795146921069114 0.896878244810393 3.4235490748616404 0.9850578416759733 0.12944443555892837 0.1135870339255387 0.1897753613497124 0.09963097903892948 0.25563351257263117 1.2674163103748472e-07 6.897080708241066 2.5266708300512475 up IGKPHTVPCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGKPHTVPCK 10 1 P15880;H0YEN5;E9PMM9;E9PPT0;I3L404;E9PM36 P15880 RPS2 40S ribosomal protein S2 0 28136900.0 1079900.0 16444000.0 10613000.0 False True 1415759.357766476 13990619.298209969 9514868.567084616 1.0 9.882060267842261 6.720682095363594 20.43314463498486 -9.812115147352609 7.228798761498044 0.9999999811250252 8.301371181602994 0.8767265705250591 1.2906272344244245 3.9473648815333167e-07 7.212710043600132e-08 1.2496444462716492 0.4165481487572591 1.5412917459517392e-10 9.812115147352609 7.301371200477968 IGKPHTVPCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGKPHTVPCK 10 1 P15880;H0YEN5;E9PMM9;E9PPT0;I3L404;E9PM36 P15880 RPS2 40S ribosomal protein S2 0 6372900.0 3968500.0 985300.0 1419100.0 False True 3842522.1397470767 1378735.4282716226 1047395.1379125516 1.0 0.3588100154349076 0.27258011790700926 21.87362214174804 -13.999999999999998 0.28274177964212555 6.3054231105636545 0.2473150809814465 0.9996112604016213 0.00639798726555014 15.548519057775476 0.16848555209425772 47.777727797148756 0.03367210075651088 1.0000000000000041e-14 13.999999999999998 -6.058108029582208 IGKPHTVPCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGKPHTVPCK 10 1 P15880;H0YEN5;E9PMM9;E9PPT0;I3L404;E9PM36 P15880 RPS2 40S ribosomal protein S2 0 27177900.0 1079900.0 14924000.0 11174000.0 False True 1479168.2132001882 14264608.332931641 8534931.335753731 1.0 9.643668790089862 5.770088391291456 20.49635469650775 -9.656577460163698 9.78365905104126 0.9999999999996432 7.706878590690659 0.7998874206447274 1.581382575783778 0.0 0.0 1.53116709499829 0.5103890316660966 2.2050708079346263e-10 9.656577460163698 6.706878590691016 IGLDFCK(ub)YLVLDEADR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGLDFCKYLVLDEADR 16 1 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 1 61290800.0 5716800.0 13466000.0 42108000.0 True False 8672803.554062728 11062887.089661771 33785335.343407944 1.0 1.275583727995248 3.895549476337601 23.048067001033793 -6.927034578484492 0.7707472637643802 0.955472218983289 4.394927330310246 0.9959226128589281 0.08332226853440573 0.0942070251240178 0.08544048410110132 0.07461214907718552 0.2410425065310746 1.1829473658210809e-07 6.927034578484492 3.4394551113269567 up IGLDFCK(ub)YLVLDEADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGLDFCKYLVLDEADR 16 1 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 1 49320200.0 5716800.0 6700800.0 36902600.0 True False 7400510.294975206 6327894.589523408 30186705.45265141 1.0 0.8550619264484933 4.079003237539925 22.819193323126242 -6.8963708985560555 0.9838902052327222 0.8522902646872846 4.393578872207812 0.9846737620583178 0.18406415196034231 0.1141274315443208 0.19285143301379618 0.1412069623673604 0.36115666837388927 1.2694894657613953e-07 6.8963708985560555 3.541288607520528 up IGLETSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGLETSLR 8 0 Q9Y230;Q9Y230-2 Q9Y230 RUVBL2 RuvB-like 2 0 43346500.0 0.0 8517500.0 34829000.0 False True 0.0 8141168.686394077 26603107.52577118 0.0 IGLETSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGLETSLR 8 0 Q9Y230;Q9Y230-2 Q9Y230 RUVBL2 RuvB-like 2 0 16343300.0 5777100.0 5731200.0 4835000.0 False True 4803914.61892416 5700324.888045867 5845976.145485853 1.0 1.1865999586234235 1.2169192438301628 22.195779079245877 -13.445403455367211 0.26270577854068516 2.0938707904033696e-11 1.2279201811351756 0.9995362566895073 0.002065437528417482 10.922429745810668 0.16010692497612997 5.764164188941477 0.013076714307388401 3.5858865447514955e-14 13.445403455367211 1.2279201811142368 IGLFADIELSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGLFADIELSR 11 0 P13796;Q5TBN3;P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13796;P13797 LCP1;PLS3 Plastin-2;Plastin-3 0 266533000.0 70877000.0 94386000.0 101270000.0 False True 107525590.80277473 77542080.85881612 81253940.11178228 1.0 0.7211500097780921 0.7556707152701876 26.680104817336975 -10.146787736233696 7.75349058634657 1.000000063423104 0.738410362636012 0.9871072977669896 0.01409301900275448 1.5450260175120362e-08 1.7046141522000168e-09 0.013645510227188493 0.004548502324621064 7.132015260407373e-11 10.146787736233696 -0.2615897007870921 IGLFADIELSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGLFADIELSR 11 0 P13796;Q5TBN3;P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13796;P13797 LCP1;PLS3 Plastin-2;Plastin-3 0 171762000.0 70877000.0 49945000.0 50940000.0 False True 91751673.6945418 47165516.84481644 41669442.68853853 1.0 0.5140562013270638 0.45415457844686047 26.451231139429424 -13.999999999999998 0.2952476080187081 5.313719263520948 0.4386773844118569 0.9996392094749955 0.004642657243797215 16.285354492933735 0.17243561870643626 42.79905816763202 0.022100167750044326 1.0000000000000041e-14 13.999999999999998 -4.875041879109091 IGLFFWPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGLFFWPK 8 0 Q9H329-2;Q9H329;Q9HCM4-2;Q9HCM4-4;Q9HCM4-3;Q9HCM4 Q9H329-2 EPB41L4B;EPB41L5 Band 4.1-like protein 4B;Band 4.1-like protein 5 0 1407620.0 358420.0 433840.0 615360.0 False True 469892.09094421705 369112.76309507457 551688.4501499288 1.0 0.78552665645716 1.1740747732981573 18.841969959452744 -6.756876004744184 1.6244157478941506 0.8749378757613225 1.1752701109796289 0.6780118337375383 0.09017169128571373 0.2881980057345315 1.4981080287967095 0.04381528150085864 0.10561459970933673 1.7503463580279793e-07 6.756876004744184 0.3003322352183063 IGLFFWPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGLFFWPK 8 0 Q9H329-2;Q9H329;Q9HCM4-2;Q9HCM4-4;Q9HCM4-3;Q9HCM4 Q9H329-2 EPB41L4B;EPB41L5 Band 4.1-like protein 4B;Band 4.1-like protein 5 0 1758890.0 358420.0 665490.0 734980.0 False True 490937.55993630073 636086.4513188599 561392.8613882483 1.0 1.2956565217812879 1.143511735914215 18.905180020975635 -10.19086724003125 4.154374129695297 0.9999045503895997 1.2195841288381255 0.7352622873050315 0.06211284880420537 5788401257.366502 2347856735.8087096 5707710.953507152 0.022730974114033867 6.443662124435659e-11 10.19086724003125 0.21967957844852581 IGLFGGAGVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGLFGGAGVGK 11 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 437470000.0 125860000.0 122630000.0 188980000.0 False True 165003678.8299739 104334082.00799607 169426162.42416376 1.0 0.6323136717182282 1.0268023332906835 27.297922949452374 -11.800836570939207 17.16335385550474 0.9014261001580582 0.8466022022540101 0.0 0.18432086687634178 0.0 0.0 0.0 0.05354754891085805 1.5818431896167252e-12 11.800836570939207 -0.05482389790404818 IGLFGGAGVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGLFGGAGVGK 11 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 357461000.0 118820000.0 46111000.0 192530000.0 False True 115048124.13877973 64523362.76568843 142100617.22380632 1.0 0.560838025380192 1.2351406708065387 26.777662219690516 -6.730953753365129 1.7198186626977248 0.7359922606658269 1.2348040497047856 0.5636347727587256 0.18459994348361378 0.3344624142612585 1.9385065703855353 0.08504627147713788 0.21080374236529234 1.8580022972991494e-07 6.730953753365129 0.49881178903895873 IGLFGGAGVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGLFGGAGVGK 11 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 380325000.0 125860000.0 95375000.0 159090000.0 False True 172393843.23861083 91161017.1370514 121516218.56139795 1.0 0.5287950858597379 0.7048756282624722 27.361133010975266 -10.226385157978475 5.03542682306074 1.000048742040873 0.616835357060829 0.863271092126802 0.0718845804208289 3.933992935779345e-05 6.043888515207395e-06 0.06961077681494286 0.02320064856811028 5.937653388963159e-11 10.226385157978475 -0.383213384980044 IGLFGGAGVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGLFGGAGVGK 11 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 259837000.0 118820000.0 69177000.0 71840000.0 False True 98804094.61850552 68804329.77044053 86861411.84936978 1.0 0.6963712388246895 0.8791276534110466 26.558067495124792 -10.297392357634209 5.51450407077727 1.0000283344617653 0.7877494468676526 0.6426555071030333 0.07460999382620385 2.599437660214332e-05 3.3119917238480976e-06 0.07225045050546579 0.024080271962457777 5.042055738455576e-11 10.297392357634209 -0.21227888759411273 IGLFGGAGVGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGLFGGAGVGK 11 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 427568000.0 79668000.0 216030000.0 131870000.0 False True 103131796.49105857 204007740.59436786 107871013.10046281 1.0 1.9781265093356066 1.0459530112986553 26.619913956671656 -6.634907816987626 2.0628490680412703 1.6420970479981067 1.0497837870122417 0.13534149867095524 0.4190484805998315 0.5463569915955125 4.436921935603229 0.16579127166085025 0.4640616361615538 2.3178865905803845e-07 6.634907816987626 -0.592313260985865 IGLFYMDNDLITR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGLFYMDNDLITR 13 0 Q15008;Q15008-4;Q15008-3;Q15008-2;C9J0E9 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 0 3200510.0 666310.0 1310100.0 1224100.0 False True 873538.862555218 1114638.1867298018 1097441.8743963311 1.0 1.2760029742344101 1.2563171730976763 19.73651236254565 -10.102975912384363 4.574682240463787 0.9999790327005418 1.2661600736736796 0.9959139499958951 0.008036694686523975 1.7187666702663105e-06 3.3701277153982047e-07 0.007782108744916298 0.002593832052953045 7.88903871999651e-11 10.102975912384363 0.2661810409731378 IGLIHGHQVIPWGDMASLALLQR ddPTM_RPMI8226_Bortezomib_2h_R1 2 IGLIHGHQVIPWGDMASLALLQR 23 0 F8VXU5;Q9UBQ0;Q9UBQ0-2 F8VXU5 VPS29 Vacuolar protein sorting-associated protein 29 0 100053100.0 53916200.0 19661100.0 26475800.0 False True 52204659.74323575 27511879.76128203 19540993.72302527 1.0 0.5270004611963167 0.3743151247251876 25.6376752504784 -13.999999999999998 0.1581565463693936 3.320611197333895 0.22112250920330764 0.9995413389534853 0.005704435890747004 11.997904109172485 0.1256107743921962 8.542448369635894 0.1393054733741867 1.0000000000000041e-14 13.999999999999998 -3.099488688130587 IGLIHGHQVIPWGDMASLALLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGLIHGHQVIPWGDMASLALLQR 23 0 F8VXU5;Q9UBQ0;Q9UBQ0-2 F8VXU5 VPS29 Vacuolar protein sorting-associated protein 29 0 77486000.0 22078000.0 25891000.0 29517000.0 False True 33493940.11800254 21270548.76269371 23682952.012239303 1.0 0.6350566307742659 0.7070816968323782 24.997396764184 -10.817962100068872 7.225858064732987 1.015911992366908 0.671069163803322 0.9652882543986517 0.029404110088771158 0.0073850462511284905 0.00018604802056340587 0.027894784528185747 0.009490135723655013 1.520680230385374e-11 10.817962100068872 -0.34484282856358595 IGLIHGHQVIPWGDMASLALLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IGLIHGHQVIPWGDMASLALLQR 23 0 F8VXU5;Q9UBQ0;Q9UBQ0-2 F8VXU5 VPS29 Vacuolar protein sorting-associated protein 29 0 109721800.0 53916200.0 24365800.0 31439800.0 False True 44833709.19264656 24234536.59916737 38013716.81878921 1.0 0.5405427531109163 0.8478824862660271 25.418080525912675 -9.919011725935274 5.413011415908204 1.0000004305441474 0.6942126196870161 0.5689466006405577 0.1254709206573073 6.520094639570771e-07 1.3009503500606425e-07 0.12148686850691016 0.04049556551084859 1.2050034048843047e-10 9.919011725935274 -0.30578781085713136 IGLIHGHQVIPWGDMASLALLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IGLIHGHQVIPWGDMASLALLQR 23 0 F8VXU5;Q9UBQ0;Q9UBQ0-2 F8VXU5 VPS29 Vacuolar protein sorting-associated protein 29 0 99724300.0 35297000.0 33925000.0 30502300.0 False True 45692662.30788897 32037043.927528292 24951194.380027696 1.0 0.7011419844975197 0.546065672687227 25.445459168620243 -13.999999999996422 0.08324770117845925 2.581667576291756 0.10956379313368927 0.9998729272114281 0.002123661309697126 12.226734277456206 0.08211010821737165 3.510941454946853 0.3948905361401219 1.0000000000082378e-14 13.999999999996422 -2.4721037831580666 IGLIQFCLSAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGLIQFCLSAPK 12 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 181904000.0 57991000.0 93102000.0 30811000.0 False True 76026762.58564277 79211544.50875363 27622973.27998154 1.0 1.0418902740929321 0.36333223118457475 26.180004022940008 -6.892202306473528 1.0092450754622326 1.034558100603982 0.3023839344734519 0.9822714978596395 0.04133899677662416 0.11737518892201804 0.21154675224246647 0.031115482059874182 0.07821384379819073 1.2817333764403096e-07 6.892202306473528 -0.73217416613053 down IGLIQFCLSAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGLIQFCLSAPK 12 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 153810000.0 99278000.0 39598000.0 14934000.0 False True 96126474.23202968 55409687.900842056 11022337.389603302 1.0 0.5764248438686557 0.11466495029244109 26.51843048317343 -7.70955467395455 0.45789091531058546 1.0282149959075093 1.088443193364479e-23 0.9969115229986248 0.020092723422010485 0.11647487517845904 0.0806225922297531 0.02877355089826899 0.07581276286922162 1.9518449980123496e-08 7.70955467395455 -1.0282149959075093 down IGLIQFCLSAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGLIQFCLSAPK 12 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 1865030000.0 567800000.0 577050000.0 720180000.0 False True 861394111.7402773 474070918.98777175 577836107.333893 1.0 0.5503530991522623 0.6708150188843163 29.682098220835 -10.243081405284594 8.144258356855794 1.0000002666079744 0.610584059018297 0.9330373823757004 0.04917837279660613 2.3808355961663482e-07 2.2129045123766082e-08 0.04761678734659017 0.015872251569569628 5.713715272720843e-11 10.243081405284594 -0.3894162075896773 IGLIQFCLSAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGLIQFCLSAPK 12 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 442111000.0 57991000.0 114030000.0 270090000.0 False True 79431839.84784889 108991777.55321601 206300304.6781572 1.0 1.3721421757570889 2.597199121577996 26.2432140844629 -6.949346514972781 0.5659709615517519 0.9844508651348574 3.0440412798353096 0.999149008853624 0.019905072917633403 0.08374918541558615 0.03705634675168613 0.021186429746170802 0.10197280289304275 1.1237080317869944e-07 6.949346514972781 2.0595904147004522 up IGLIQFCLSAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGLIQFCLSAPK 12 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 178519000.0 99278000.0 10790000.0 68451000.0 False True 82554055.76111753 10731872.12835268 82763787.61833543 1.0 0.1299981209815657 1.0025405397140605 26.298835758607705 -9.732894580963821 13.292050195794067 1.0000217208149609 0.5662693303802041 0.24781627872722256 0.35621395102548975 0.0 0.0 0.34490267490237353 0.11496755830079114 1.8497175580873228e-10 9.732894580963821 -0.4337523904347568 IGLIQFCLSAPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGLIQFCLSAPK 12 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 1574040000.0 567800000.0 569310000.0 436930000.0 False True 735028293.0112864 537627398.0362891 357413223.28039163 1.0 0.7314376917842451 0.48625777630427014 29.45322454292745 -6.972212592164973 0.19833973155453927 1.1491002393675889 0.06183792758893771 0.9999948873320956 0.00047436337763650263 0.07559105071792178 0.006391081914818224 0.00807002925708583 0.02613922191683177 1.0660741378786425e-07 6.972212592164973 -1.087262311778651 down IGLPGVAEK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGLPGVAEKSR 11 1 Q9NQT4 Q9NQT4 EXOSC5 Exosome complex component RRP46 1 5953900.0 1494100.0 1778700.0 2681100.0 True False 1446670.6133289898 2488944.1857979656 1978839.4787240832 1.0 1.720463637586831 1.3678576591602278 20.464305047094705 -10.227311562008325 4.900996173546751 0.9999111279618329 1.544160648374265 0.7605083694610628 0.14395078790269422 0.00013981531858825466 2.2042632974382537e-05 0.13940237015328724 0.0464599170179964 5.925001136576808e-11 10.227311562008325 0.544249520412432 IGLPGVAEK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGLPGVAEKSR 11 1 Q9NQT4 Q9NQT4 EXOSC5 Exosome complex component RRP46 1 5504600.0 1494100.0 2618800.0 1391700.0 True False 1242410.3498527934 2604692.0046088984 1682698.0355062373 1.0 2.0964828608498913 1.354381855967001 20.24471032252898 -10.204248362139666 4.906244204912525 0.999909542922376 1.7254323584097555 0.5602673177297193 0.3029614665994942 0.0002998039910753411 4.862481993027433e-05 0.29337743787590365 0.09778039288955387 6.248152743757828e-11 10.204248362139666 0.7255228154873795 IGLTK(ub)ALTQMEEAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGLTKALTQMEEAQR 15 1 O95229;O95229-2 O95229 ZWINT ZW10 interactor 1 17317600.0 4522300.0 4080900.0 8714400.0 True False 4378742.061881868 5710424.651612365 6431837.213603788 1.0 1.3041244656366386 1.4688778472691204 22.062085036926096 -11.540332937078041 0.0981883686701188 1.5784981049066204e-18 1.8856624812009704 0.99987791202816 0.0021459611895546797 4.533722502473048 0.06686275199449355 1.2730421659011308 0.2940024708702377 2.8818214058240877e-12 11.540332937078041 1.8856624812009704 IGLTK(ub)ALTQMEEAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGLTKALTQMEEAQR 15 1 O95229;O95229-2 O95229 ZWINT ZW10 interactor 1 8314300.0 4522300.0 0.0 3792000.0 True False 3760492.8218588415 0.0 4584889.667772978 1.0 0.0 1.2192257464559206 21.842490312360372 -6.688775556375768 1.871106540627463 0.3723264011444408 1.2149084390331353 0.364526937873374 0.4230381931859902 0.41931810465022945 2.845413395659789 0.18094753434875047 0.47186943004180243 2.047502513757085e-07 6.688775556375768 0.8425820378886945 IGLTK(ub)LNCFLEQDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGLTKLNCFLEQDLK 15 1 P52732 P52732 KIF11 Kinesin-like protein KIF11 1 15839600.0 0.0 8397200.0 7442400.0 True False 0.0 6898654.052376945 5971406.377880206 0.0 IGLTK(ub)LNCFLEQDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGLTKLNCFLEQDLK 15 1 P52732 P52732 KIF11 Kinesin-like protein KIF11 1 13225900.0 0.0 6399000.0 6826900.0 True False 0.0 6042890.024826919 5584474.249909376 0.0 IGMSVNAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGMSVNAIR 9 0 A0A1W2PPZ5;P23193;A0A1W2PRL9;P23193-2;E5RJ93;E5RIS7 A0A1W2PPZ5 TCEA1 Transcription elongation factor A protein 1 0 11993100.0 0.0 3238000.0 8755100.0 False True 0.0 2754903.0216251416 7849206.236849382 0.0 IGMSVNAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGMSVNAIR 9 0 A0A1W2PPZ5;P23193;A0A1W2PRL9;P23193-2;E5RJ93;E5RIS7 A0A1W2PPZ5 TCEA1 Transcription elongation factor A protein 1 0 12948900.0 0.0 3706500.0 9242400.0 False True 0.0 3542734.5742435795 7059535.473203008 0.0 IGMSVNAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGMSVNAIR 9 0 A0A1W2PPZ5;P23193;A0A1W2PRL9;P23193-2;E5RJ93;E5RIS7 A0A1W2PPZ5 TCEA1 Transcription elongation factor A protein 1 0 8320300.0 3681500.0 0.0 4638800.0 False True 4765774.323214239 0.0 3794585.9981074343 1.0 0.0 0.7962160481716233 22.18427920560093 -10.742206100211474 10.370585546533523 1.0012765706712825 0.39810802408760926 0.43243994996116375 0.325053840505958 0.00960554923006278 0.0002387760436206665 0.31510663793722227 0.10491067590836144 1.810480701067792e-11 10.742206100211474 -0.6031685465836732 IGNFSTDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGNFSTDIK 9 0 P13796 P13796 LCP1 Plastin-2 0 34072000.0 0.0 16470000.0 17602000.0 False True 0.0 14012740.199557181 15780713.89030653 0.0 IGNFSTDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGNFSTDIK 9 0 P13796 P13796 LCP1 Plastin-2 0 28792800.0 8073300.0 5786500.0 14933000.0 False True 7817017.510601002 8097079.626198853 11021599.319602657 1.0 1.0358272340081172 1.409949421842254 22.898186838825307 -6.925497082099198 0.7828527848967581 0.9932629132602971 1.4786357872708507 0.9955772986058663 0.01232875317436333 0.09504356877963821 0.08962919396655056 0.01094468541258878 0.03472712825420299 1.1871426770899858e-07 6.925497082099198 0.4853728740105535 IGNFSTDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGNFSTDIK 9 0 P13796 P13796 LCP1 Plastin-2 0 40141000.0 0.0 22126000.0 18015000.0 False True 0.0 21148400.15910247 13760228.030571302 0.0 IGNFSTDIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGNFSTDIK 9 0 P13796 P13796 LCP1 Plastin-2 0 11953800.0 8073300.0 2114700.0 1765800.0 False True 6713306.657831856 2103307.691364914 2135020.6158632706 1.0 0.3133042773952774 0.31802816773944326 22.678592114259583 -10.032329449349067 5.589462295669548 1.000002669991562 0.31566622256701427 0.9999642633944661 0.0019285201585650367 6.416680701038665e-08 1.1111110961945328e-08 0.0018672889015063719 0.0006224272045682824 9.282619538846827e-11 10.032329449349067 -0.6843364474245478 IGNFSTDIK(ub)DSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGNFSTDIKDSK 12 1 P13796 P13796 LCP1 Plastin-2 1 4034700.0 1197200.0 1302900.0 1534600.0 True False 1159195.5413141474 1823154.7645337407 1132642.2229868255 1.0 1.5727758601166473 0.977093322583678 20.14469252021473 -6.655102673217103 1.9906186856992694 1.3701669362766602 0.9796068469061476 0.21493333991232566 0.24416335806509995 0.4961099714034966 3.7738290962724603 0.09928608088945554 0.27048641364818155 2.212571565274909e-07 6.655102673217103 -0.39056008937051256 IGNFSTDIK(ub)DSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGNFSTDIKDSK 12 1 P13796 P13796 LCP1 Plastin-2 1 4757100.0 1197200.0 2074100.0 1485800.0 True False 995524.8449526571 2062926.4116233836 1796473.9104369965 1.0 2.0721998271389075 1.8045495494614492 19.925097795649005 -10.145543224422816 4.6204605183135135 0.9998942226973152 1.9383746883138646 0.9424928111061914 0.10926776835076894 76402780.69217467 17.89375402047041 85981.12201399854 0.037405263451726095 7.152482033726862e-11 10.145543224422816 0.9384804656165494 IGNSYFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGNSYFK 7 0 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 12685300.0 1175100.0 7138700.0 4371500.0 False True 1540567.4796845885 6073633.786434657 3919179.1143889977 1.0 3.9424652710948798 2.5439840617636555 20.5550304457775 -9.35880857643125 13.16231603706037 0.9999958958812729 3.2432171223636828 0.7742973076171635 0.5709275629934535 0.0 0.0 0.5527982358839285 0.18426607862797614 4.377149938700225e-10 9.35880857643125 2.24322122648241 IGNSYFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGNSYFK 7 0 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 12554300.0 1175100.0 5721800.0 5657400.0 False True 1609566.2258834543 5468991.956537676 4321238.637810383 1.0 3.39780486729328 2.6847224850524887 20.618240507300392 -9.949302236671077 5.456668738126623 0.9999962278461693 3.0412636761783567 0.9161489420459725 0.2911146635289385 1.3358884347908847e-05 2.572469845438619e-06 0.2818710810817757 0.09395685363757607 1.1238226047825956e-10 9.949302236671077 2.0412674483321873 IGNSYFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGNSYFK 7 0 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 4888590.0 3891500.0 635340.0 361750.0 False True 3235954.6726806406 631917.2973148841 437390.2524569815 1.0 0.19528002127156144 0.13516575375719053 21.62575996882357 -13.738074213677557 0.3704162493359168 9.99999999999999 0.1289003481793397 0.9997850581690632 0.005780527238576272 18.73081173861373 0.19713356818717967 132.79414887543243 0.016785925153494027 1.8277878510208667e-14 13.738074213677557 -9.87109965182065 IGNTEDGAPHK(ub)EDEPSVGQVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGNTEDGAPHKEDEPSVGQVAR 22 1 Q9C0C9 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 11764300.0 4352700.0 4643100.0 2768500.0 True False 5706431.8516067555 3950367.578662047 2482042.177327219 1.0 0.6922657943509385 0.43495519474719607 22.444157500715594 -7.266360224599219 0.18982978835675093 1.1954161104081835 1.2765193262163375e-13 0.9999858469756387 0.000868956335375814 0.10194602807938304 0.010617942650028186 0.01812360720900012 0.04360345912595349 5.415515153519953e-08 7.266360224599219 -1.1954161104080558 down IGNTEDGAPHK(ub)EDEPSVGQVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGNTEDGAPHKEDEPSVGQVAR 22 1 Q9C0C9 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 40152000.0 13305000.0 13373000.0 13474000.0 True False 20184657.725791417 10986483.66627409 10810857.994136019 1.0 0.5442987349860213 0.5355977862494142 24.266755787245465 IGNTEDGAPHK(ub)EDEPSVGQVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGNTEDGAPHKEDEPSVGQVAR 22 1 Q9C0C9 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 12398800.0 4352700.0 5192000.0 2854100.0 True False 5962010.817294614 4962600.272351983 2180020.3620346114 1.0 0.8323702228041018 0.365651862910212 22.507367562238485 -6.953116122328933 0.5235230406424004 1.0077203080980313 0.16934819176921506 0.9994236507432781 0.006443432218427135 0.08225818017263116 0.030967417390530605 0.00725931822328811 0.038565253841322866 1.1139966316278699e-07 6.953116122328933 -0.8383721163288163 down IGNTGGMLDNILASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGNTGGMLDNILASK 15 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 42917900.0 6572900.0 24656000.0 11689000.0 False True 8617135.552054154 20977420.908335235 10479534.408805445 1.0 2.4343844635627945 1.2161273715030898 23.038776947731034 -6.606337724421678 2.1681010295394176 1.9606874300479666 1.2204119600318744 0.03899985242092452 0.6189934674941159 0.6227280869588991 5.541936653266998 0.23625860004758703 0.6873116002758034 2.4754962659621245e-07 6.606337724421678 -0.7402754700160923 IGNTGGMLDNILASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGNTGGMLDNILASK 15 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 38293100.0 15816000.0 8675100.0 13802000.0 False True 15313929.737240693 12139112.670048853 10186842.148875384 1.0 0.7926843650411127 0.6652010505247935 23.8683412073332 -11.784867712442942 0.058144083001254926 2.1106363269635415 5.080562099208592e-09 0.9999785379424504 0.0006391509014803657 5.2327410762937125 0.04287663245448682 1.2226175285340593 0.4786576323336862 1.6410895784690194e-12 11.784867712442942 -2.1106363218829793 IGPILDNSTLQSEVK(ub)PILEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGPILDNSTLQSEVKPILEK 20 1 P30153;B3KQV6;E9PH38 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 13207800.0 3700200.0 3540300.0 5967300.0 True False 3582739.1763870763 4953960.2524206 4404285.114837271 1.0 1.3827298077043657 1.2293066556071945 21.772631588415802 -10.234935746298886 5.4135465734127095 0.9999779181054239 1.3060182316558084 0.8413853144820953 0.06263473956134691 1.6694216335104564e-05 2.3592539210138706e-06 0.06065019713269268 0.02021527526791356 5.82189346088624e-11 10.234935746298886 0.3060403135503845 IGPILDNSTLQSEVK(ub)PILEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGPILDNSTLQSEVKPILEK 20 1 P30153;B3KQV6;E9PH38 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 10923900.0 3700200.0 2851800.0 4371900.0 True False 3076880.24665371 2836436.787362018 5286044.07661832 1.0 0.9218547879615437 1.7179882390181442 21.553036863850078 -6.882782479186733 1.0641962272091605 0.9495327173577294 1.777500316177367 0.9758599105365815 0.05567013878520566 0.1251922499714921 0.25765399432824976 0.040191918287162606 0.0979161226417253 1.309837804334402e-07 6.882782479186733 0.8279675988196377 IGPILDNSTLQSEVK(ub)PILEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGPILDNSTLQSEVKPILEK 20 1 P30153;B3KQV6;E9PH38 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 39814000.0 7431000.0 10770000.0 21613000.0 True False 9619575.986908885 10170640.032409117 17679655.768107273 1.0 1.057285689748713 1.837883061807216 23.197541873395853 -6.921641903730941 0.8124552138893063 0.9837748264619647 1.9686419716348098 0.9946250384945473 0.028020343766188765 0.09721521005997526 0.10067817999524672 0.024354733653212644 0.07413965465257522 1.1977277072094742e-07 6.921641903730941 0.9848671451728451 IGPILDNSTLQSEVKPILEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGPILDNSTLQSEVKPILEK 20 1 P30153;B3KQV6;E9PH38 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0 12924500.0 4350600.0 2641600.0 5932300.0 False True 4212492.584398043 3696404.6557620135 4378452.66481477 1.0 0.8774863294602624 1.0393971210848891 22.006242715924525 -6.704302863081431 1.8152295248639256 0.9242494022329679 1.038961538396779 0.4381901740035028 0.051674673848154065 0.38661976892826033 2.4795089142697884 0.022683998334214844 0.05803580951813847 1.9755914453255476e-07 6.704302863081431 0.11471213616381104 IGPILDTNALQGEVK(ub)PVLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGPILDTNALQGEVKPVLQK 20 1 P30154;P30154-2;P30154-4;P30154-3;P30154-5;H0YDG7 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 27687500.0 2408500.0 2092000.0 23187000.0 True False 2332043.4858462457 2927346.50963588 17113629.104910407 1.0 1.2552709790373453 7.338469118941091 21.15316326019097 -6.915716542870518 0.8558798788907139 0.8439636944509586 8.228941165940537 0.9929062331446765 0.24674992988322106 0.10075840096416913 0.11915460728424011 0.20791126473681304 0.5994358920793426 1.214181068654634e-07 6.915716542870518 7.384977471489578 up IGPILDTNALQGEVK(ub)PVLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGPILDTNALQGEVKPVLQK 20 1 P30154;P30154-2;P30154-4;P30154-3;P30154-5;H0YDG7 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 114474900.0 3570900.0 8264000.0 102640000.0 True False 5417316.367758639 6789224.633073295 82353159.01128979 1.0 1.2532449966333181 15.201836743635225 22.369146915047086 -6.910834303637366 0.890020276060274 0.5794347925557924 17.037086219290934 0.9912329265532958 0.6213392584358557 0.10386927094238149 0.13578869496235998 0.5108061358122379 1.4183672041884798 1.2279076253645827e-07 6.910834303637366 16.457651426735143 up IGPILDTNALQGEVK(ub)PVLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGPILDTNALQGEVKPVLQK 20 1 P30154;P30154-2;P30154-4;P30154-3;P30154-5;H0YDG7 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 17530700.0 2408500.0 2588200.0 12534000.0 True False 2002774.464641226 2574256.852882526 15154801.449331868 1.0 1.2853453538232895 7.566903671326106 20.933568535625245 -6.916398745019612 0.8509978515956932 0.8426102189485891 8.500491303892266 0.993120882218945 0.2513635664123099 0.10033756370396882 0.1169332451465068 0.21254220034341986 0.6163142366941847 1.2122752956423058e-07 6.916398745019612 7.657881084943677 up IGPILDTNALQGEVK(ub)PVLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGPILDTNALQGEVKPVLQK 20 1 P30154;P30154-2;P30154-4;P30154-3;P30154-5;H0YDG7 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 155594600.0 3570900.0 7373700.0 144650000.0 True False 4622600.442962314 6963347.112996771 118325184.23433645 1.0 1.506370104644915 25.59710398818501 22.140273237139535 -6.911440388007679 0.885871075857462 0.28765766734505016 28.808263991480093 0.9914538532388362 1.0610598044315027 0.10347305480011948 0.13365841792312078 0.8749392549026934 2.440017484099399 1.2261952007464692e-07 6.911440388007679 28.52060632413504 up IGPITPLEFYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGPITPLEFYR 11 0 Q13867;K7ESE8;K7ES02;J3KSD8 Q13867 BLMH Bleomycin hydrolase 0 9075000.0 1858100.0 3190100.0 4026800.0 False True 2435987.093865995 2714149.514912406 3610145.3637931156 1.0 1.1141887909615145 1.4820051275656356 21.21607505902784 -6.949841623956433 0.5605779138560933 0.995203933015551 1.6185860173365616 0.9991888077986352 0.005857432060242769 0.08354936237389723 0.036225779718783 0.006274459100227572 0.030579367133872406 1.1224277002316564e-07 6.949841623956433 0.6233820843210106 IGPITPLEFYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGPITPLEFYR 11 0 Q13867;K7ESE8;K7ES02;J3KSD8 Q13867 BLMH Bleomycin hydrolase 0 7709600.0 3828600.0 1501000.0 2380000.0 False True 3707063.188669686 2100357.1276115924 1756606.601530457 1.0 0.5665824995999933 0.47385396798721185 21.821845276119614 -13.999999999999986 0.2167209254842825 3.57846081789979 0.4226674953466983 0.9994948269573908 0.005154151196190962 12.912453228872659 0.14750328514372654 14.224507715115394 0.05245115632483687 1.0000000000000327e-14 13.999999999999986 -3.1557933225530914 IGPITPLEFYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGPITPLEFYR 11 0 Q13867;K7ESE8;K7ES02;J3KSD8 Q13867 BLMH Bleomycin hydrolase 0 9780200.0 1858100.0 4215000.0 3707100.0 False True 2545089.78326444 4028767.362858947 2831559.330121055 1.0 1.5829568722292693 1.1125577371534519 21.279285120550732 -10.188997081433195 10.274211752447352 0.9999999984116523 1.3477573046913605 0.42153594144280826 0.19203964273038224 7.070311572522072e-09 5.393592497627526e-10 0.18594158452659795 0.061980528175532706 6.471469647223361e-11 10.188997081433195 0.34775730627970813 IGPITPLEFYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGPITPLEFYR 11 0 Q13867;K7ESE8;K7ES02;J3KSD8 Q13867 BLMH Bleomycin hydrolase 0 6090440.0 3828600.0 1291500.0 970340.0 False True 3183650.5357381776 1284542.4331573225 1173233.6076547548 1.0 0.40348097843580744 0.3685183390841994 21.60225055155389 -13.846716317351575 0.40490441532725935 9.999999999999956 0.3666733980242299 0.999842112182043 0.0036413593894909987 24.13968334080635 0.21003751004867513 190.3187097123467 0.0088301087416112 1.423258160677643e-14 13.846716317351575 -9.633326601975726 IGPK(ub)KPLPDHVSIVEPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGPKKPLPDHVSIVEPK 17 2 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 172419600.0 31794600.0 37515000.0 103110000.0 True False 48234732.69661393 30820155.14396715 82730263.30528165 1.0 0.6389618729271143 1.7151595682231138 25.523569035641575 -6.816230621756045 1.3880620758284605 0.804628954507279 1.7368154159803157 0.8755007381324992 0.15779701150560832 0.19842661084702165 0.7522078188048351 0.08935535929208409 0.20618937769781542 1.5267550959522236e-07 6.816230621756045 0.9321864614730367 IGPK(ub)KPLPDHVSIVEPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGPKKPLPDHVSIVEPK 17 2 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 92305300.0 7463300.0 10849000.0 73993000.0 True False 10222683.698098863 10369655.30715461 56517377.333669774 1.0 1.0143770083665096 5.528624283286829 23.28527065204085 -6.9075957577377185 0.9119285670117273 0.8493799130656151 6.083023876658939 0.9899827210139064 0.2133274002915761 0.10603022233750073 0.14754138127810498 0.17260362299770715 0.4689022598926112 1.23709839161751e-07 6.9075957577377185 5.233643963593324 up IGPK(ub)KPLPDHVSIVEPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGPKKPLPDHVSIVEPK 17 2 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 42531700.0 9406700.0 13310000.0 19815000.0 True False 7822087.837467561 13238296.38817184 23958224.885791503 1.0 1.6924249207175617 3.0628938697200945 22.899122306106786 -6.960248467143249 0.4319174579884301 0.9466571324060604 3.861383639539683 0.9997793047070613 0.012734445264578634 0.07961247322918676 0.020804207861171268 0.017904425511472647 0.1137416012688507 1.095851062026037e-07 6.960248467143249 2.9147265071336226 IGPK(ub)KPLPDHVSIVEPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGPKKPLPDHVSIVEPK 17 2 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 215979600.0 31794600.0 31705000.0 152480000.0 True False 41158736.46526351 29940588.87906511 124730204.57692108 1.0 0.7274418859853458 3.030467290515317 25.294695357734025 -6.87737848415282 1.0943751298468463 0.8362960910745775 3.185655562194901 0.9715059257599001 0.17343667518045858 0.12997471057529306 0.28656780300669 0.12235976486983208 0.2940100249996005 1.3262381480516535e-07 6.87737848415282 2.3493594711203234 up IGPYQPNVPVGIDYVIPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGPYQPNVPVGIDYVIPK 18 0 P43243;A8MXP9;A0A0R4J2E8;P43243-2;B3KM87;Q68E03 P43243 MATR3;DKFZp686L22104 Matrin-3 0 20256400.0 1401900.0 13063000.0 5791500.0 False True 1837904.4760189117 11114051.319175197 5192251.135990814 1.0 6.0471321900523165 2.825093035976363 20.809630354691553 -9.48877709066816 9.44119916648942 0.9999016915285973 4.436112613015742 0.6026058563677207 1.3153919776836986 0.0 0.0 1.273622805272636 0.42454093509087854 3.2450613313018257e-10 9.48877709066816 3.4362109214871444 IGPYQPNVPVGIDYVIPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGPYQPNVPVGIDYVIPK 18 0 P43243;A8MXP9;A0A0R4J2E8;P43243-2;B3KM87;Q68E03 P43243 MATR3;DKFZp686L22104 Matrin-3 0 16486600.0 5073200.0 2683100.0 8730300.0 False True 4912154.042929284 3754475.822181662 6443572.52661402 1.0 0.7643237140712185 1.311761086949036 22.2279243730057 -6.789764878291639 1.497782115623625 0.8682386511142809 1.3175038983534424 0.8003962860161296 0.10016980169166696 0.23570957258408634 1.044707616359909 0.05264761273123843 0.12325504835080571 1.622688363183124e-07 6.789764878291639 0.4492652472391615 IGPYQPNVPVGIDYVIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGPYQPNVPVGIDYVIPK 18 0 P43243;A8MXP9;A0A0R4J2E8;P43243-2;B3KM87;Q68E03 P43243 MATR3;DKFZp686L22104 Matrin-3 0 19693300.0 1401900.0 7864400.0 10427000.0 False True 1920220.3149229966 7516924.80390697 7964357.350805824 1.0 3.9146158102219686 4.147626857663573 20.872840416214444 -10.121640428729558 0.5626965435494033 3.087634949421367e-14 4.1276183508620035 0.9995411591382422 0.030675269550099096 1.4081008661183667 0.26549697275764506 2.3759303861413317 0.04252729638469585 7.557176602030112e-11 10.121640428729558 4.127618350861972 IGPYQPNVPVGIDYVIPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGPYQPNVPVGIDYVIPK 18 0 P43243;A8MXP9;A0A0R4J2E8;P43243-2;B3KM87;Q68E03 P43243 MATR3;DKFZp686L22104 Matrin-3 0 6324200.0 5073200.0 1251000.0 0.0 False True 4218590.580866878 1244260.614695941 0.0 1.0 0.29494699493693416 0.0 22.008329648439975 -8.782731164509498 0.4882518640947838 1.0817764231766636 1.2218951857610666e-18 0.995164598534954 0.029173289887898236 0.36786564484210227 0.19289390002659118 0.12358672522512656 0.060242273776015556 1.6491829472315235e-09 8.782731164509498 -1.0817764231766636 IGQGASGTVFTATDVALGQEVAIK(ub)QINLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGQGASGTVFTATDVALGQEVAIKQINLQK 30 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 48123000.0 12648000.0 11647000.0 23828000.0 True False 19187940.692657664 9568501.851573648 19118385.35581657 1.0 0.498672682224574 0.9963750494148801 24.193696549694256 -10.904890355022594 11.028398544513898 1.0225586580719046 0.747523865823959 0.2554622398266664 0.2031861405652603 0.0924684091713774 0.0007974522732794874 0.16141772936675988 0.06557804488245106 1.2448288501713224e-11 10.904890355022594 -0.2750347922479456 IGQGASGTVFTATDVALGQEVAIK(ub)QINLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGQGASGTVFTATDVALGQEVAIKQINLQK 30 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 10746700.0 3736000.0 3895300.0 3115400.0 True False 3106649.5328626228 3874315.245743486 3766815.7360179108 1.0 1.2471040601008823 1.2125010227809565 21.56692806674793 -10.095741885170822 4.51740721021218 0.9999812276975558 1.2298025414496243 0.9832792028157877 0.014126630862896714 9829210.163042292 0.08469599657171197 1932.317458878651 0.004835921485924355 8.021546674160578e-11 10.095741885170822 0.2298213137520685 IGQGASGTVFTATDVALGQEVAIK(ub)QINLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGQGASGTVFTATDVALGQEVAIKQINLQK 30 1 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 1 35249000.0 12648000.0 11487000.0 11114000.0 True False 16373085.329353198 10847738.352115456 9091366.039270079 1.0 0.6625347717859835 0.5552628509772277 23.964822871786705 -13.999999999999998 0.16038159090963983 2.663316290269316 0.45025200356750483 0.9995353682436062 0.004084658805656311 12.012247726650342 0.12656938539216228 6.215158995661144 0.09575398071892072 1.0000000000000041e-14 13.999999999999998 -2.2130642867018113 IGQGTFGEVFK(ub)AR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGQGTFGEVFKAR 13 1 P50750;P50750-2;X6RE90 P50750 CDK9 Cyclin-dependent kinase 9 1 19277500.0 3196900.0 3930600.0 12150000.0 True False 3095416.1593945837 5500109.077808216 8967550.507813066 1.0 1.7768560977222378 2.8970419633549316 21.561701953152586 -6.965904854084195 0.34216693718803404 0.8815095282998079 3.8297380349410632 0.9999306012450426 0.006486866649735156 0.07765522763266913 0.013784648476233287 0.015710442233733864 0.09680475834322556 1.081670899497564e-07 6.965904854084195 2.9482285066412555 IGQGTFGEVFK(ub)AR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGQGTFGEVFKAR 13 1 P50750;P50750-2;X6RE90 P50750 CDK9 Cyclin-dependent kinase 9 1 32952600.0 3089200.0 5089400.0 24774000.0 True False 4686542.250771501 4181156.8063363 19877408.04117008 1.0 0.8921624051608615 4.241380313577212 22.160092458488844 -6.899459064231176 0.9646702708333198 0.8586774738596149 4.589113989898151 0.9862955848586583 0.18192533154239485 0.11180492405625446 0.17966921350158002 0.141583526074614 0.3673909802533 1.2604944440952115e-07 6.899459064231176 3.7304365160385364 up IGQGTFGEVFK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGQGTFGEVFKAR 13 1 P50750;P50750-2;X6RE90 P50750 CDK9 Cyclin-dependent kinase 9 1 17972500.0 3196900.0 4981500.0 9794100.0 True False 2658363.996683217 4954663.670749673 11842001.02719812 1.0 1.8638018258340463 4.454619849641782 21.342107228586862 -6.951455721109407 0.5426265979302419 0.9625016638735687 5.476103890410592 0.9993106289002184 0.038541316302274344 0.0829064080690685 0.033583500490115964 0.042239799656241354 0.21464845350405073 1.1182638323827039e-07 6.951455721109407 4.513602226537023 IGQGTFGEVFK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGQGTFGEVFKAR 13 1 P50750;P50750-2;X6RE90 P50750 CDK9 Cyclin-dependent kinase 9 1 30531500.0 3089200.0 5955300.0 21487000.0 True False 3999030.2972357534 5623882.3198705735 17576586.475238096 1.0 1.406311506006335 4.39521213114778 21.931218780581293 -6.931691807608704 0.7327715883725182 0.9572806000715837 5.03611959566753 0.99686044472809 0.08482447387047114 0.09176878007671511 0.07344591206334994 0.07807196812921358 0.2679721636960281 1.1703296081815822e-07 6.931691807608704 4.078838995595946 up IGQGYLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGQGYLIK 8 0 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 0 32593900.0 3123900.0 16088000.0 13382000.0 False True 4095463.1518906374 13687733.110532848 11997359.009208173 1.0 3.3421697627077944 2.929426676362523 21.965595183376557 -10.150165086439793 5.093427772548699 0.9999005322513785 3.1357982195347662 0.9727539565851041 0.168501659411552 0.00019178866875902068 3.199985626565409e-05 0.16315845692384767 0.054383676724286935 7.07676727226544e-11 10.150165086439793 2.1358976872833875 IGQGYLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGQGYLIK 8 0 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 0 23477400.0 8269800.0 4458600.0 10749000.0 False True 8007279.725659653 6238942.231291837 7933514.436912149 1.0 0.77915877114907 0.9907877217638446 22.932880775396942 -10.631993219797478 8.342420057513909 1.000097888510005 0.8849732464719521 0.28258857141905 0.08639715730114303 0.00015743207514097254 6.944715091846328e-06 0.08372458493008092 0.02788456261558245 2.3334944924969067e-11 10.631993219797478 -0.11512464203805284 IGQGYLIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGQGYLIK 8 0 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 0 76975560.0 2483400.0 73641000.0 851160.0 False True 3767499.3608591068 60499188.19024086 682927.8529233193 1.0 16.058181407745526 0.18126820670981894 21.845175836399967 -6.613626740756598 2.1399119781926874 9.999999999999998 0.23916723896712572 0.26116175790353624 6.274017217926501 0.4981608412679672 4.326949930186919 2.4904035602827004 7.176261865577194 2.434295292536086e-07 6.613626740756598 -9.760832761032873 IGQGYLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGQGYLIK 8 0 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 0 34322900.0 3123900.0 13507000.0 17692000.0 False True 4278890.250223236 12910216.078324024 13513513.978177482 1.0 3.0171879443859253 3.1581819555835677 22.02880524489945 -10.388892209948247 0.5425434776766526 7.703938448364742e-14 3.147766637812416 0.9996607066676635 0.018158831650128385 1.7473438145195246 0.2586427333310303 2.5586558886592403 0.026579226351596916 4.084207420532039e-11 10.388892209948247 3.1477666378123392 IGQGYLIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGQGYLIK 8 0 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 0 11273900.0 8269800.0 1768200.0 1235900.0 False True 6876705.114257839 1758674.355639779 1494320.9758440454 1.0 0.2557437503017871 0.2173018838259896 22.71328605083122 -13.480127106575473 0.42712287053910275 9.982825439611421 0.21635105558006118 0.9998648102516109 0.004188647071333581 19.612680688691274 0.21842848673320053 162.19446341008089 0.009164966443360921 3.310342222907403e-14 13.480127106575473 -9.76647438403136 IGQGYLIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGQGYLIK 8 0 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 0 6227200.0 2483400.0 1981800.0 1762000.0 False True 3214810.2551324856 1871511.0878577908 1441334.0796467387 1.0 0.582152892186996 0.4483418818717622 21.616302158492417 -13.999999999999998 0.15931046766202092 3.054867724393071 0.31579311708024804 0.9995381980842849 0.0050490477385990535 12.005160785723685 0.12610962071807108 7.62311198020333 0.12070261058622792 1.0000000000000041e-14 13.999999999999998 -2.739074607312823 IGQGYLIK(ub)DGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGQGYLIKDGK 11 1 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 1 39602200.0 16347000.0 16328000.0 6927200.0 True False 21431075.304573167 13891926.046045518 6210439.794394477 1.0 0.6482141399167743 0.28978666287777144 24.35320090329064 -7.40344358020374 0.30139473828039676 1.0817405636418105 2.0570411332274495e-12 0.9997833267504667 0.004267974140945646 0.11648590155315322 0.026322516824217015 0.01785029586645761 0.05761342516089416 3.949630062061336e-08 7.40344358020374 -1.0817405636397535 down IGQGYLIK(ub)DGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGQGYLIKDGK 11 1 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 1 51709000.0 19933000.0 16991000.0 14785000.0 True False 19300237.82577258 23775594.906894468 10912364.959507491 1.0 1.231880929215583 0.5654005436625066 24.202115289318815 -6.8127239398037505 1.4029961712742638 1.1259722595757928 0.5529933728503432 0.8668359725378354 0.10080927410658086 0.20310788258191445 0.7874236603975613 0.05648925095807411 0.13052097227270756 1.5391326823332674e-07 6.8127239398037505 -0.5729788867254496 IGQGYLIK(ub)DGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGQGYLIKDGK 11 1 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 1 37469000.0 16347000.0 13252000.0 7870000.0 True False 22390927.661064412 12666482.821496269 6011268.087737782 1.0 0.5656970989871946 0.2684689164616782 24.416410964813533 -8.203307664674155 0.23993163941821877 1.2125508169996728 4.623022400366615e-12 0.999572223115888 0.0062128708341510075 0.08823091509040322 0.05139608300824479 0.09350635827967375 0.10528648597728131 6.261701135145658e-09 8.203307664674155 -1.2125508169950499 down IGQGYLIK(ub)DGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGQGYLIKDGK 11 1 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 1 56454900.0 19933000.0 29941000.0 6580900.0 True False 16575172.681624912 29779701.890176814 7956935.763356328 1.0 1.7966450463101555 0.4800514550401828 23.98252056475309 -6.742872944257483 1.6760122487474625 1.4724071014459363 0.4787577096407545 0.6178619964842349 0.33470321146946813 0.3126312596276202 1.7253528745993294 0.15791030653955102 0.38630726714288716 1.8077029041799354e-07 6.742872944257483 -0.9936493918051819 IGQQPQQPGAPPQQDYTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGQQPQQPGAPPQQDYTK 18 0 A0A087WTP3;Q92945;M0QYG1;M0R0C6 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 5193420.0 1208500.0 623520.0 3361400.0 False True 1170136.828999456 872494.7876138452 2480948.5001615454 1.0 0.7456348402946053 2.1202208482600446 20.158245809369575 -6.858913161737851 1.1911642925163002 0.8623624755300061 2.185431263087963 0.9523066578189644 0.13040615909790038 0.1479313698577596 0.3994534728563165 0.08542174198647139 0.19916891779390206 1.3838430541714925e-07 6.858913161737851 1.3230687875579568 up IGRPGYK(ub)VTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGRPGYKVTK 10 2 Q15428;K7EMT0 Q15428 SF3A2 Splicing factor 3A subunit 2 1 2568320.0 657680.0 1394500.0 516140.0 True False 862224.8489821793 1186446.035718427 462734.78396448266 1.0 1.3760285813137692 0.5366753051837022 19.71770461545794 -6.784917325268186 1.5166379236096619 1.2115580453014005 0.5289626899766525 0.7844253333173349 0.15938577800094275 0.2430089467600866 1.1042796863905797 0.08274671851259445 0.1944668495144821 1.640902114792946e-07 6.784917325268186 -0.682595355324748 IGRPGYK(ub)VTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGRPGYKVTK 10 2 Q15428;K7EMT0 Q15428 SF3A2 Splicing factor 3A subunit 2 1 4282500.0 1415700.0 1552100.0 1314700.0 True False 1370759.3784150002 2171861.624094574 970340.6298454182 1.0 1.5844222248589557 0.7078854575975373 20.386543913574627 -6.727001833984475 1.7343105689221832 1.3528720022009455 0.7086992059609506 0.5452690033891268 0.2457399480846148 0.3418758956796291 2.0131549174302887 0.11235488350357101 0.27973656013032644 1.874986590159868e-07 6.727001833984475 -0.6441727962399949 IGRPGYK(ub)VTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGRPGYKVTK 10 2 Q15428;K7EMT0 Q15428 SF3A2 Splicing factor 3A subunit 2 1 5571100.0 1290000.0 1271200.0 3009900.0 True False 1957024.3116325417 1044344.4280690666 2414991.945713964 1.0 0.5336389649640473 1.2340122354940943 20.9002302476465 -6.72722863604601 1.7334165722806758 0.718477156774493 1.233381129831264 0.5462944637263281 0.19609413120679636 0.34147847411328625 2.0088371090293937 0.08969679101626037 0.223271317890881 1.8740076695853506e-07 6.72722863604601 0.514903973056771 IGRPGYK(ub)VTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGRPGYKVTK 10 2 Q15428;K7EMT0 Q15428 SF3A2 Splicing factor 3A subunit 2 1 2195650.0 657680.0 822330.0 715640.0 True False 900842.0691337155 785996.7415183383 546620.5710684453 1.0 0.8725133610536008 0.6067884591514435 19.78091467698083 -6.959228948303192 0.446167201126498 1.008912831375643 0.4599219422762356 0.9997405246210723 0.0026385447405525898 0.07997769528184 0.022157708501403257 0.0035320850398256444 0.021992993080027775 1.098426625968334e-07 6.959228948303192 -0.5489908890994074 IGRPGYK(ub)VTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGRPGYKVTK 10 2 Q15428;K7EMT0 Q15428 SF3A2 Splicing factor 3A subunit 2 1 4145750.0 1415700.0 2012800.0 717250.0 True False 1177217.2761438997 2001956.6468904833 867223.6588106974 1.0 1.7005838152903303 0.7366725551729759 20.166949189008903 -6.711804052607241 1.7889890852716706 1.4299096847364283 0.7388348680931275 0.47359388459517515 0.29513992443062165 0.37144810542228923 2.318532181430949 0.13123810219856782 0.3326523233222451 1.941761774827591e-07 6.711804052607241 -0.6910748166433008 IGRPGYK(ub)VTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGRPGYKVTK 10 2 Q15428;K7EMT0 Q15428 SF3A2 Splicing factor 3A subunit 2 1 7245400.0 1290000.0 1646800.0 4308600.0 True False 1669930.4297015835 1555154.1323464569 3524479.009969321 1.0 0.931268814967557 2.110554396328442 20.67135656973895 -6.89307018241423 1.004028071966928 0.9412202485847702 2.218307826777825 0.9827922588445982 0.07089521630591211 0.11668805437680184 0.20757217407176395 0.053572469085182116 0.13512318108280724 1.2791745715885027e-07 6.89307018241423 1.277087578193055 up IGSGGFGLIYLAFPTNKPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGSGGFGLIYLAFPTNKPEK 20 1 Q86Y07-5;Q86Y07-2;Q86Y07-3;Q86Y07;E7ERS5 Q86Y07-5 VRK2 Serine/threonine-protein kinase VRK2 0 4334840.0 915840.0 1791800.0 1627200.0 False True 1200675.109007175 1524470.424381696 1458832.953204567 1.0 1.2696777112688407 1.2150105738519557 20.1954143939449 -10.057243020140476 4.391210913541381 0.9999827002062034 1.2423441425698019 0.9632393547428852 0.022317765487049626 7734663.835074388 0.22298165093764102 1373.505421370846 0.0076399647303298955 8.765102110806312e-11 10.057243020140476 0.24236144236359847 IGSGGFGLIYLAFPTNKPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGSGGFGLIYLAFPTNKPEK 20 1 Q86Y07-5;Q86Y07-2;Q86Y07-3;Q86Y07;E7ERS5 Q86Y07-5 VRK2 Serine/threonine-protein kinase VRK2 0 5869800.0 2374300.0 1652100.0 1843400.0 False True 2298929.1461261134 2311792.1455876837 1360558.2391853991 1.0 1.0055952135294146 0.5918226063983106 21.132530571653557 -6.903835203206836 0.9366964275157802 1.015440130745451 0.5448414208479585 0.9883798478932185 0.02088551662639959 0.10863728851673433 0.16192344091482733 0.01659431146923974 0.04406897832536432 1.2478569345099826e-07 6.903835203206836 -0.47059870989749253 IGSGGFGLIYLAFPTNKPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGSGGFGLIYLAFPTNKPEK 20 1 Q86Y07-5;Q86Y07-2;Q86Y07-3;Q86Y07;E7ERS5 Q86Y07-5 VRK2 Serine/threonine-protein kinase VRK2 0 6861740.0 915840.0 1698300.0 4247600.0 False True 1254450.7976453924 1623263.4904729158 3244404.3620679798 1.0 1.2940033148528312 2.5863145594532173 20.258624455467793 -6.942714538083829 0.633805508154567 0.985895004164323 2.9645273078498104 0.9984982882077721 0.026701361374309143 0.08654975464378455 0.0491317667836035 0.026561327419785605 0.10996562203552514 1.1409995205216821e-07 6.942714538083829 1.9786323036854876 up IGSLIDVNQSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGSLIDVNQSK 11 0 P61326;Q96A72;F5H6P7;P61326-2 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 0 16309000.0 1510200.0 6643600.0 8155200.0 False True 1979886.8247976026 5652400.776549975 7311378.134202247 1.0 2.8549110513565856 3.692826298265642 20.916986533987732 -9.175309398849041 0.27053263376249304 2.468905130704334e-13 4.157096159143525 0.9989323156310052 0.03676549305761944 0.6032341110083507 0.09837512832519126 0.8973807896678914 0.32587286273974947 6.678679474459764e-10 9.175309398849041 4.157096159143278 IGSLIDVNQSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGSLIDVNQSK 11 0 P61326;Q96A72;F5H6P7;P61326-2 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 0 15823200.0 2599300.0 1323900.0 11900000.0 False True 2516786.644284883 1852540.1740472964 8783033.007652303 1.0 0.7360735874270642 3.4897805213631465 21.26315148932777 -6.883394551272336 1.0607295069349194 0.8277726081771296 3.6980612139027302 0.9763202460830565 0.19090476849275745 0.12466376336814886 0.25449909161495965 0.13819227221288125 0.33724864425232104 1.3079930871953557e-07 6.883394551272336 2.8702886057256007 up IGSLIDVNQSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGSLIDVNQSK 11 0 P61326;Q96A72;F5H6P7;P61326-2 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 0 24821400.0 1510200.0 5774200.0 17537000.0 False True 2068561.7516204494 5519076.751274041 13395121.785852265 1.0 2.6680744468713886 6.475572593063237 20.980196595510623 -6.957380553418497 0.4709001248777104 0.9003081463847259 8.399664674461466 0.9996603740947344 0.042231108542878266 0.08065044606644114 0.024691823723501274 0.052734303545019484 0.31423398484554693 1.1031115874391556e-07 6.957380553418497 7.49935652807674 IGSLIDVNQSK(ub)DPEGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGSLIDVNQSKDPEGLR 17 1 P61326;Q96A72;F5H6P7;P61326-2 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 31030100.0 8607100.0 10072000.0 12351000.0 True False 11283991.451274963 8569296.8603485 11073036.99915784 1.0 0.7594207153870421 0.9813049794456121 23.427774142265747 -10.43775106507338 7.727034667432412 1.0000058642499714 0.8703628474700695 0.3127807472751739 0.09058387148274356 9.151650147216297e-06 6.65791348990792e-07 0.08771142350696208 0.02923581880730491 3.649630815767943e-11 10.43775106507338 -0.12964301677990187 IGSLIDVNQSK(ub)DPEGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGSLIDVNQSKDPEGLR 17 1 P61326;Q96A72;F5H6P7;P61326-2 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 58892000.0 18530000.0 12195000.0 28167000.0 True False 17941775.292809185 17064527.09608485 20789217.70811278 1.0 0.9511058308106265 1.1587046080353494 24.09681931251862 -6.844613111307654 1.2607147490716568 0.9739823849534028 1.1661839300246646 0.9321045735335103 0.02309043096813669 0.163484920208632 0.5027299662633749 0.014349046086417573 0.03311161766301266 1.430167447470366e-07 6.844613111307654 0.19220154507126175 IGSLIDVNQSK(ub)DPEGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGSLIDVNQSKDPEGLR 17 1 P61326;Q96A72;F5H6P7;P61326-2 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 39680100.0 8607100.0 11066000.0 20007000.0 True False 11789377.46813162 10577067.529631572 15281758.657099066 1.0 0.897169299924691 1.2962311791617371 23.49098420378864 -6.838319438675041 1.2902144450162607 0.9452794573861558 1.3089230137170718 0.92152054986101 0.047392611002468193 0.17077029537707566 0.5529351042308945 0.02881106644564931 0.06634688810872319 1.451043931767454e-07 6.838319438675041 0.36364355633091594 IGSLIDVNQSK(ub)DPEGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGSLIDVNQSKDPEGLR 17 1 P61326;Q96A72;F5H6P7;P61326-2 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 51808000.0 18530000.0 15110000.0 18168000.0 True False 15408516.018186385 15028599.43089983 21966844.80065911 1.0 0.9753437263628667 1.4256301369146809 23.877224587952895 -6.893951144537481 0.9987000164751727 0.9780471194838452 1.4674975399691157 0.9833096134215014 0.026703933529461404 0.11599648329287582 0.20358227147556615 0.02026007768159063 0.05128358311493249 1.2765824084165128e-07 6.893951144537481 0.48945042048527054 IGSLIDVNQSK(ub)DPEGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGSLIDVNQSKDPEGLR 17 1 P61326;Q96A72;F5H6P7;P61326-2 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 93213000.0 15506000.0 31720000.0 45987000.0 True False 20072822.668955628 29954754.115879014 37617837.866466835 1.0 1.4923040276844899 1.874068161058689 24.25874016901212 -6.973966775851187 0.13273827203860647 0.4319792412527059 2.944294221055126 0.9999991467436488 0.00033044390519896145 0.07503526345773902 0.003994234678487624 0.023312269318675697 0.051450107702514104 1.0617767815336958e-07 6.973966775851187 2.51231497980242 IGSTIDDTISK(ub)FR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGSTIDDTISKFR 13 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 100291600.0 52383600.0 34431000.0 13477000.0 True False 68675406.88350393 29294029.010986794 12082529.32051252 1.0 0.4265577786918554 0.17593677080076806 26.03329021712205 -9.712036987685808 0.22760213003631113 1.5084547640872332 2.0525719551707935e-24 0.9992485205314406 0.009455328389859852 1.1422755582001436 0.09648906122407189 0.5114207160592339 0.12289408002133752 1.9407205846335633e-10 9.712036987685808 -1.5084547640872332 IGSTIDDTISK(ub)FR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGSTIDDTISKFR 13 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 179859200.0 110679100.0 43060100.0 26120000.0 True False 107165652.55317645 60254222.48545498 19278388.416796464 1.0 0.5622531198189303 0.1798933516243031 26.675267343706153 -7.837430381815348 0.35268410717316745 1.0751402567070611 4.7064810513566006e-12 0.9987413996430133 0.011886896456994709 0.11254517069173736 0.06188369268088336 0.03926659591454295 0.08157938558862507 1.4540174485327316e-08 7.837430381815348 -1.0751402567023547 down IGSTIDDTISK(ub)FR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGSTIDDTISKFR 13 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 189762800.0 110679100.0 49731300.0 29352400.0 True False 92034575.56548597 49463387.61600989 35489851.12983632 1.0 0.5374435348030141 0.3856143293080544 26.45567261914043 -13.999999999999998 0.15573416642061286 3.2587033709436715 0.22910373652305663 0.9995482428224118 0.005553733536932434 11.983946949526084 0.12455133523597159 8.180428117282668 0.14192072931257263 1.0000000000000041e-14 13.999999999999998 -3.029599634420615 IGSTIDDTISK(ub)FR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGSTIDDTISKFR 13 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 121362400.0 6574400.0 31790000.0 82998000.0 True False 8510690.400798503 30020858.554344095 67893215.63139628 1.0 3.527429284882391 7.977403998273313 23.020844739708625 -6.962458749864578 0.3992751002734067 0.7534147834694481 10.913713337199455 0.9998507975128911 0.035231673711630065 0.07883424846518605 0.017969925888228617 0.05726376531887656 0.37293613680659643 1.090288045148445e-07 6.962458749864578 10.160298553730007 IGTDIQDNK(ub)CSWLVVQCLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGTDIQDNKCSWLVVQCLQR 20 1 P14324;P14324-2;A0A087X090 P14324 FDPS Farnesyl pyrophosphate synthase 1 74264000.0 20672000.0 27644000.0 25948000.0 True False 27101192.187932786 23519622.955468003 23263149.870791633 1.0 0.8678445875137726 0.8583810523711906 24.691852981686885 -13.999999999999998 0.3742651023474961 2.8909293072414304 0.85746482125503 0.9997981035469868 0.0009185214116724465 23.32707874015917 0.19896882061319376 35.454417297643126 0.0026101716501183785 1.0000000000000041e-14 13.999999999999998 -2.0334644859864004 IGTDIQDNK(ub)CSWLVVQCLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGTDIQDNKCSWLVVQCLQR 20 1 P14324;P14324-2;A0A087X090 P14324 FDPS Farnesyl pyrophosphate synthase 1 469703000.0 44023000.0 101230000.0 324450000.0 True False 66786109.51240253 83164715.58639997 260322315.28851324 1.0 1.2452397091786855 3.897851172782718 25.99304473964429 -6.9249475551273925 0.7871611177507949 0.95123237282425 4.378397337668419 0.9954485996145217 0.08851838521834111 0.0953473276442597 0.0911641222956733 0.07833977387791134 0.24701758515209826 1.1886457581843784e-07 6.9249475551273925 3.4271649648441693 up IGTDIQDNK(ub)CSWLVVQCLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGTDIQDNKCSWLVVQCLQR 20 1 P14324;P14324-2;A0A087X090 P14324 FDPS Farnesyl pyrophosphate synthase 1 136622000.0 20672000.0 54376000.0 61574000.0 True False 28314997.03979472 51973488.52261399 47031489.35633618 1.0 1.8355463166592931 1.6610098630855146 24.755063043209777 -10.058819678522475 4.472739989590572 0.9999555470516285 1.7482780898456982 0.9607952791566986 0.07125420899105113 21954159.66437448 29517829.06616081 12989.15133416489 0.026076367605333665 8.733339062004954e-11 10.058819678522475 0.7483225427940697 IGTDIQDNK(ub)CSWLVVQCLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGTDIQDNKCSWLVVQCLQR 20 1 P14324;P14324-2;A0A087X090 P14324 FDPS Farnesyl pyrophosphate synthase 1 372165000.0 44023000.0 75942000.0 252200000.0 True False 56988641.32306411 71715760.94161683 206302187.79052633 1.0 1.2584220166798825 3.620058015087875 25.76417106173674 -6.927708273131693 0.7653714786489113 0.9608690826892784 4.07775519476705 0.9960683398334778 0.07392217513708278 0.09384527564679135 0.08363915823511897 0.06645050688213443 0.21644239930394574 1.1811137539873334e-07 6.927708273131693 3.116886112077772 up IGTPTRPCPLPPGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGTPTRPCPLPPGKR 15 2 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 10361500.0 5048700.0 3422200.0 1890600.0 True False 4888431.782018663 4788702.306537238 1395395.1432157485 1.0 0.9795988816192005 0.2854484230195239 22.22094028947783 -6.913181547995106 0.8737973857138381 1.0193908822837112 0.18936031020461253 0.9920675396827319 0.029581720016903717 0.10235171162427065 0.127636875346657 0.02460649749533662 0.06951913193048276 1.2212890183498436e-07 6.913181547995106 -0.8300305720790987 down IGTPTRPCPLPPGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGTPTRPCPLPPGKR 15 2 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 25759200.0 15895500.0 5756400.0 4107300.0 True False 24114635.61670935 4729125.4450415205 3295490.3547064597 1.0 0.19611017641770406 0.13665934692469375 24.523405674687123 -13.728845486764044 0.3719818941504982 9.999999999998904 0.13061321997019393 0.9997875712999437 0.0057384223836432985 18.731834774475526 0.19768472939136827 133.41393097198034 0.01651981466860938 1.8670438293020503e-14 13.728845486764044 -9.86938678002871 IGTPTRPCPLPPGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGTPTRPCPLPPGKR 15 2 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 12098800.0 3705400.0 4675400.0 3718000.0 True False 5075386.514669852 4468825.368519737 2839884.974613599 1.0 0.8804896643049912 0.5595406313204365 22.275086263851364 -6.953910187856612 0.5141302448569597 1.0057118690793185 0.4201384400277174 0.9994734759760182 0.0042675030055914125 0.0819526186814926 0.029750894663681405 0.004880998191153893 0.02649668652285134 1.1119616572907408e-07 6.953910187856612 -0.5855734290516011 IGTSNYYWAFPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGTSNYYWAFPSK 13 0 D6RCT6;A0A087WTC6;D6R9E3;Q9BWT6;D6RIA0 D6RCT6 MND1 Meiotic nuclear division protein 1 homolog 0 5759700.0 1846800.0 1310400.0 2602500.0 False True 2421172.6844366402 1114893.4278991923 2333218.2649427797 1.0 0.46047662567224373 0.9636728020024207 21.207274549154963 -10.609695805930649 9.535353732319395 1.0000546501368093 0.7120747138373323 0.30388276645793455 0.2054289787547473 0.00023871162653272816 9.771078799536375e-06 0.19894322054660735 0.06630191779546113 2.4564288764389708e-11 10.609695805930649 -0.28797993629947694 IGTSNYYWAFPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGTSNYYWAFPSK 13 0 D6RCT6;A0A087WTC6;D6R9E3;Q9BWT6;D6RIA0 D6RCT6 MND1 Meiotic nuclear division protein 1 homolog 0 5993070.0 1846800.0 997070.0 3149200.0 False True 2529611.867893423 953016.1505304318 2405423.819809887 1.0 0.37674402252234535 0.9509062834264154 21.270484610677855 -10.66129496274855 9.647096864838058 1.0001815703425652 0.6638251529743835 0.31369968355215583 0.23440076146295308 0.0009158622471076779 3.2155547717063415e-05 0.22707644969970733 0.07565252045702948 2.1812479555776808e-11 10.66129496274855 -0.33635641736818167 IGTVSIFHMSDSYSETPLEDFVPQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGTVSIFHMSDSYSETPLEDFVPQK 25 0 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 0 50556400.0 13768600.0 26946000.0 9841800.0 False True 18050767.935312074 22925761.834685326 8823464.945211848 1.0 1.270071274354842 0.48881382647166044 24.105556879323952 -6.813334340510173 1.4002704389894802 1.1466171224614272 0.47405005345301526 0.868415021866714 0.11751920897772983 0.20227853618815214 0.7810124024749043 0.0659769126638221 0.15241531405099093 1.5369709515258547e-07 6.813334340510173 -0.672567069008412 down IGTVSIFHMSDSYSETPLEDFVPQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGTVSIFHMSDSYSETPLEDFVPQK 25 0 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 0 29176700.0 5121600.0 9151600.0 14903500.0 False True 4959017.611422098 12805881.604963524 10999826.254583705 1.0 2.58234243320043 2.218146237119187 22.24162291826221 -10.052671182562765 6.05392135619043 0.9999974227911064 2.4002443351598686 0.9517129784541831 0.14868247444382324 5.1720713526472995e-06 8.093315081113495e-07 0.14396145051673895 0.04798706228278841 8.857860112854912e-11 10.052671182562765 1.4002469123687622 IGTVSIFHMSDSYSETPLEDFVPQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGTVSIFHMSDSYSETPLEDFVPQK 25 0 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 0 153514400.0 28536400.0 111576000.0 13402000.0 False True 43291805.09028749 91664391.05273311 10753088.82569474 1.0 2.1173612618268485 0.2483862431531457 25.367590620467816 -6.744767992041931 1.6690767415556524 1.6611211994575716 0.24607410348295547 0.6262187218257271 0.46945186852201803 0.3092567445683549 1.6933022538262779 0.22234338886161364 0.5428158690186289 1.799832161204172e-07 6.744767992041931 -1.4150470959746162 IGTVSIFHMSDSYSETPLEDFVPQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGTVSIFHMSDSYSETPLEDFVPQK 25 0 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 0 29150300.0 13768600.0 7704400.0 7677300.0 False True 18859223.502424408 7363994.132956211 5864079.858956696 1.0 0.39047175680427926 0.3109396236914448 24.168766940846844 -13.999999999999998 0.28707588656308874 6.166726584454425 0.28862117292302386 0.9996209229224192 0.005992786202546887 15.794249853872568 0.16985107883855827 48.11114698415667 0.03043952759081919 1.0000000000000041e-14 13.999999999999998 -5.8781054115314015 IGTVSIFHMSDSYSETPLEDFVPQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGTVSIFHMSDSYSETPLEDFVPQK 25 0 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 0 67702400.0 28536400.0 29837400.0 9328600.0 False True 36940932.33653974 28176922.46081746 7630890.519519064 1.0 0.7627561265676706 0.2065700575719105 25.138716942560265 -7.073932604098437 0.5183362981532585 1.0087378682840598 8.900322352309362e-14 0.9994484881097717 0.007809122447781161 0.07487338547615262 0.03073504896824843 0.008946671957410012 0.04186663796551495 8.434656406537857e-08 7.073932604098437 -1.0087378682839707 down IGVAAVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGVAAVVR 8 0 Q8TCB6 Q8TCB6 OR51E1 Olfactory receptor 51E1 0 21354200.0 5683000.0 3817200.0 11854000.0 False True 7450468.034250292 3247688.639329058 10627461.791597199 1.0 0.43590397601858294 1.4264153262240784 22.82889962704429 -6.752253941028585 1.6418022497522664 0.6692034071370448 1.428691930783037 0.6585056740388087 0.237066171449973 0.2961232823887283 1.5711839200542528 0.114039858634572 0.2761734537893509 1.7690742412833554e-07 6.752253941028585 0.7594885236459922 IGVAAVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGVAAVVR 8 0 Q8TCB6 Q8TCB6 OR51E1 Olfactory receptor 51E1 0 17497000.0 5117600.0 3038100.0 9341300.0 False True 4955144.58923261 4251229.173482203 6894533.297006919 1.0 0.8579425074134073 1.3913889237437282 22.240495724642177 -6.835868022779582 1.301482164799968 0.9243440921908183 1.407543137729057 0.9171068099916695 0.06494385288196826 0.1736814535963268 0.573250606033401 0.03915307029426063 0.0901239027854092 1.4592576449280572e-07 6.835868022779582 0.4831990455382388 IGVAAVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGVAAVVR 8 0 Q8TCB6 Q8TCB6 OR51E1 Olfactory receptor 51E1 0 15821400.0 5683000.0 3634000.0 6504400.0 False True 7784158.677300377 3473437.8639690117 4968194.682322947 1.0 0.44621878971943496 0.6382442712544969 22.89210968856718 -10.08628624495477 5.363444119458738 1.0000057543093983 0.5422315304866215 0.8834127868849583 0.07839407456339667 5.394202466292915e-06 9.188480804656182e-07 0.07590569054053582 0.025301578768606947 8.198110260140999e-11 10.08628624495477 -0.45777422382277677 IGVAAVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGVAAVVR 8 0 Q8TCB6 Q8TCB6 OR51E1 Olfactory receptor 51E1 0 9463600.0 5117600.0 1507400.0 2838600.0 False True 4255511.148120379 1499279.3370045281 3432138.135796512 1.0 0.35231474782218497 0.8065160720616268 22.020901000076453 -9.763452475077436 5.903286438803886 1.0000000210940119 0.5794154099401918 0.5334231406971706 0.18542691415385237 66805448.53070551 110489651.74531116 12.47612743932994 0.06347654832913156 1.7240407427904538e-10 9.763452475077436 -0.42058461115382006 IGVAIGDQILDLSIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGVAIGDQILDLSIIK 16 0 P16930;H0YLC7 P16930 FAH Fumarylacetoacetase 0 154462000.0 43286000.0 64313000.0 46863000.0 False True 65668026.63048541 52835842.67023754 37600507.50921746 1.0 0.8045900780229824 0.5725847027625158 25.968687766121434 -6.96885140718053 0.2842896778878623 1.0485427658713216 0.32152061370441914 0.9999719823329015 0.0009247235853942385 0.0766772365116144 0.010358179343925841 0.004182260756903395 0.021182288317786478 1.0743569381234055e-07 6.96885140718053 -0.7270221521669025 IGVAIGDQILDLSIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGVAIGDQILDLSIIK 16 0 P16930;H0YLC7 P16930 FAH Fumarylacetoacetase 0 80758000.0 43286000.0 20232000.0 17240000.0 False True 56034580.29462226 19106071.414642654 14102496.89733812 1.0 0.3409692963556702 0.25167489116879427 25.739814088213883 -13.999999999999998 0.2816700338475414 6.420774698887638 0.2252329245886849 0.9996088793783695 0.00659978282160601 15.489311939594893 0.16814863136332223 48.41560238521379 0.035044714047937076 1.0000000000000041e-14 13.999999999999998 -6.195541774298953 IGVDLIMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGVDLIMK 8 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 16792200.0 5310400.0 5463600.0 6018200.0 False True 6961985.82598675 4648452.176945991 5395494.394650769 1.0 0.6676905545533981 0.7749935908388673 22.731067446183896 -10.70592851785442 9.85957474241535 1.0003512785606679 0.7213420726961328 0.8999201876129945 0.04380628112512467 0.0003386630543861064 1.0101002202550197e-05 0.04246601875486671 0.014138416438074007 1.968210218094924e-11 10.70592851785442 -0.27900920586453504 IGVDLIMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGVDLIMK 8 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 19014800.0 6909200.0 4971500.0 7134100.0 False True 6689871.227904863 6956645.876030015 5265465.191587586 1.0 1.0398773965950763 0.7870802011291669 22.673547010287912 -6.866551977381226 1.1521119042327477 1.0221471455160165 0.7732096788305276 0.9611227540665144 0.02188053932497472 0.14020748882522613 0.3499855119892 0.014767269471606356 0.03476929026329814 1.3597154196184588e-07 6.866551977381226 -0.24893746668548888 IGVDLIMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 IGVDLIMK 8 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 57440600.0 11914800.0 25337800.0 20188000.0 False True 18075622.688557684 20816071.62486503 16197832.95128526 1.0 1.1516102091488176 0.8961147967277989 24.107542011759733 -6.745936654204555 1.6647004845192896 1.0895828790956674 0.8957554535716327 0.6313338314705743 0.06369936682109924 0.3072095880409138 1.6736677702294136 0.03024316041482572 0.0737434360125542 1.794995424128184e-07 6.745936654204555 -0.19382742552403476 IGVDLIMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGVDLIMK 8 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 22380900.0 5310400.0 6565500.0 10505000.0 False True 7273798.388163975 6275414.50079488 8023935.357266249 1.0 0.8627424305581964 1.1031286446326183 22.794277507706788 -6.751826316445382 1.6429688553261337 0.9194686163125154 1.103676979164048 0.656825310747045 0.05768271438623946 0.296877833349683 1.5772299091106594 0.027727348030119645 0.06718902542216666 1.7708170039237898e-07 6.751826316445382 0.18420836285153253 IGVDLIMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGVDLIMK 8 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 38687900.0 10507000.0 18721000.0 9459900.0 False True 13601518.623933744 17679159.892918404 7738295.266770816 1.0 1.2997930879430986 0.5689287704355469 23.697264403106626 -6.795321969364027 1.4748242206201199 1.1664077244102944 0.5599569705531475 0.8181335792905672 0.12792641644110783 0.22752292667335666 0.9774218572171569 0.0682523191311871 0.15921109860894883 1.602057246185283e-07 6.795321969364027 -0.6064507538571469 IGVFSYGSGLAATLYSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGVFSYGSGLAATLYSLK 18 0 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 0 87664000.0 29178000.0 26707000.0 31779000.0 False True 44265159.197530456 21940927.18725657 25497866.720769465 1.0 0.49567035530916265 0.5760256414528379 25.39966827429574 -10.736407735736906 6.929786923039944 1.0069186597317883 0.5358479983811915 0.9780155559259714 0.03280490819788995 0.003515969073982433 0.00013373877468932443 0.03184835022967839 0.010587738593690907 1.8348149253878472e-11 10.736407735736906 -0.47107066135059683 IGVFSYGSGLAATLYSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGVFSYGSGLAATLYSLK 18 0 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 0 82193000.0 29178000.0 31264000.0 21751000.0 False True 37771496.1843665 29524130.916735284 17792541.18410683 1.0 0.7816510834684707 0.47105735757089506 25.170794596388188 -6.966124201419337 0.3382027045590059 1.0343975020857645 0.20801708749531775 0.9999344784093593 0.0017567628802380641 0.07758150498363 0.013526083580721299 0.004408978284736305 0.02691893221900735 1.0811247223461236e-07 6.966124201419337 -0.8263804145904468 down IGVGAMTWSPLACGIVSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGVGAMTWSPLACGIVSGK 19 0 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28;Q13303-5;A0A590UJJ4 Q13303-3 KCNAB2 Voltage-gated potassium channel subunit beta-2 0 4383060.0 1154900.0 2365100.0 863060.0 False True 1514085.0840675102 2012236.299087594 773758.8302561061 1.0 1.329011374764902 0.5110405210369311 20.530014849227218 -6.797541529353899 1.466032728551023 1.1820993374721618 0.5004356136689031 0.8248497405853044 0.1406428909050105 0.22428546054638357 0.9519289921976005 0.07548224017156821 0.17580525730697685 1.5938904578548703e-07 6.797541529353899 -0.6816637238032587 IGVGAMTWSPLACGIVSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGVGAMTWSPLACGIVSGK 19 0 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28;Q13303-5;A0A590UJJ4 Q13303-3 KCNAB2 Voltage-gated potassium channel subunit beta-2 0 8591400.0 1154900.0 2378800.0 5057700.0 False True 1581897.73999898 2273696.750360342 3863175.426601185 1.0 1.4373222066565494 2.4421145115256793 20.59322491075011 -6.9572447128689605 0.47267209948160627 0.9741382259140224 2.946675569878402 0.9996539483383194 0.011231109385197223 0.08070052659167401 0.024882878388691604 0.0139636008799195 0.08291619890110524 1.1034566775286572e-07 6.9572447128689605 1.9725373439643796 up IGVGVAVLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGVGVAVLNR 10 0 Q14145;K7EQX2 Q14145 KEAP1 Kelch-like ECH-associated protein 1 0 18913900.0 6092500.0 7255400.0 5566000.0 False True 9242767.921411823 5960617.183301057 4465877.660335534 1.0 0.6448952558348536 0.48317535378010185 23.139893527946587 -13.999999999999853 0.1058810655328674 2.7274261048701156 0.16810691680616904 0.999764001415714 0.003316091503393294 12.038430220711932 0.09804188213775453 4.4821354403017075 0.28021041657177637 1.0000000000003395e-14 13.999999999999853 -2.5593191880639465 IGVGVAVLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGVGVAVLNR 10 0 Q14145;K7EQX2 Q14145 KEAP1 Kelch-like ECH-associated protein 1 0 18631200.0 6092500.0 7654500.0 4884200.0 False True 7886861.351129372 7228520.346153729 3995325.7161240624 1.0 0.9165268697310913 0.5065799356992557 22.911019850039036 -6.940206106881592 0.6576429005236986 1.004585725756993 0.39535663305862756 0.9981907766783483 0.009172042351578508 0.08767271792219684 0.054182330939167994 0.008942300821266068 0.03525138847201705 1.1476088615965122e-07 6.940206106881592 -0.6092290926983654 IGVITNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGVITNR 7 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 14953800.0 1376800.0 8566000.0 5011000.0 False True 1804998.1329501655 7287986.190006479 4492509.788906156 1.0 4.037669655699136 2.4889276652953694 20.7835659141458 -9.714506652452124 13.967980998982714 1.0000005471418059 3.2632986604972567 0.7400912294332481 0.6322712699520172 0.0 2.835725295158564e-17 0.6121940155799617 0.2040646749007862 1.929715776891346e-10 9.714506652452124 2.263298113355451 IGVITNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGVITNR 7 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 13248400.0 4171900.0 1574800.0 7501700.0 False True 4039465.318082605 2203625.8524735123 5536779.7238239655 1.0 0.5455241421702557 1.3706714349145803 21.94573291329127 -6.757162528205561 1.6230022344405237 0.7350878184847421 1.3732858956834797 0.6793364687155359 0.1910847313523525 0.28771039628887396 1.4929855185944125 0.09292115549757136 0.22394755139283185 1.7491919572276908e-07 6.757162528205561 0.6381980771987376 IGVITNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGVITNR 7 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 15953600.0 1376800.0 7524300.0 7052500.0 False True 1885840.1666210007 7191851.546467269 5386844.750796777 1.0 3.813606091206256 2.8564694114288516 20.84677597566869 -10.49380288453996 5.773563699372753 0.9972091752099015 3.3350377513175524 0.8880878363747888 0.390749413259387 0.014034388212372143 0.0012304641485020482 0.37826901103981764 0.1261138308411599 3.207724900679432e-11 10.49380288453996 2.337828576107651 IGVLDEGK(ub)MK ddPTM_RPMI8226_Bortezomib_1h_R1 2 IGVLDEGKMK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 1 29357300.0 7698900.0 8405400.0 13253000.0 True False 10093332.45625366 7151347.083992586 11881706.691752788 1.0 0.7085218994804565 1.1771837243299244 23.26689924344825 -6.738513715289981 1.6920227078579937 0.8262690994320776 1.1773744158425725 0.5982239361877002 0.12247255351531927 0.3205509272090701 1.801345038376451 0.057273386913799275 0.1407799685654907 1.825939083871949e-07 6.738513715289981 0.3511053164104949 IGVLDEGK(ub)MK ddPTM_RPMI8226_Bortezomib_2h_R1 2 IGVLDEGKMK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 1 36495600.0 8351500.0 7373200.0 20770900.0 True False 8086386.203879973 10317357.21073004 15330378.176356725 1.0 1.2758922157068893 1.895825624677804 22.947063677350915 -6.9577054232611975 0.46665333881724685 0.9830819098866374 2.213907235122132 0.9996753863620842 0.006749209296557542 0.08053127202701416 0.024239212769146957 0.008518666471641012 0.05117978980606014 1.1022867238973189e-07 6.9577054232611975 1.2308253252354944 IGVLDEGK(ub)MK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGVLDEGKMK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 1 160541900.0 5360900.0 26263000.0 128918000.0 True False 8132877.23428751 21576162.45624443 103437300.7932333 1.0 2.652955631161035 12.718414137268734 22.95533440591598 -6.935522429056903 0.6999757915347175 0.8736714216595156 15.108985237744928 0.997516682986219 0.2580677443620374 0.08986991566972372 0.06436368576927883 0.24338446176451284 0.8847383902536967 1.1600523039177573e-07 6.935522429056903 14.235313816085412 IGVLDEGK(ub)MK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGVLDEGKMK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 1 21880200.0 6784200.0 1497000.0 13599000.0 True False 9292502.076111406 1430857.5900829977 10387196.280196449 1.0 0.15397979772975876 1.1178040311553135 23.147635674735156 -6.674897774962848 1.9203001620652738 0.46226171827713136 1.1139752269866936 0.3007536236814029 0.35897379022594367 0.4499928573521043 3.2036862568268933 0.15025732516049142 0.3988614716393053 2.11398657534289e-07 6.674897774962848 0.6517135087095622 IGVLDEGK(ub)MK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IGVLDEGKMK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 1 29024400.0 8351500.0 10620600.0 10052300.0 True False 6944642.284181522 10563384.719775964 12154189.453416206 1.0 1.5210840656022266 1.7501534213073824 22.72746895278519 -10.93033259597324 0.15964344978938402 8.659938619584566e-18 2.027867619344897 0.9995980281555186 0.006293213348525839 3.058314744196837 0.0910997545663567 1.3298158127967579 0.19642970077146166 1.1739981269710239e-11 10.93033259597324 2.027867619344897 IGVLDEGK(ub)MK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGVLDEGKMK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 1 164844900.0 5360900.0 35808000.0 123676000.0 True False 6939790.729137375 33815253.32223822 101168237.0229229 1.0 4.872661819651369 14.57799535628047 22.72646072800843 -6.955409541197969 0.49591845807551826 0.798563786806569 19.067795758877406 0.9995602424796506 0.11976464157716799 0.08138360427984737 0.02751537703415598 0.14155508245343665 0.8005138062262867 1.1081293525916673e-07 6.955409541197969 18.269231972070838 IGVNQPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IGVNQPK 7 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 9758050.0 122150.0 4959100.0 4676800.0 False True 160139.83290228277 4219221.6104204 4192889.599033384 1.0 26.34710886076025 26.182677495310507 17.288972680372854 -10.323471560175749 6.4632931839237955 0.998928689949183 26.264893178035383 0.999968232585939 0.06712882384350677 0.001036065588985095 0.00010844501202531019 0.06498326314198564 0.021665734733031364 4.7481938352564463e-11 10.323471560175749 25.2659644880862 IGVNQPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGVNQPK 7 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 6905900.0 2779200.0 1045500.0 3081200.0 False True 2690975.8172571696 1462973.6022104756 2274141.2859813655 1.0 0.5436591413525375 0.8450991166094272 21.359697995427023 -10.179246426854865 5.326122507769446 1.0000129941815377 0.6943791289808948 0.5781615609599873 0.12306235457640283 1.8989285880003647e-05 2.92619217860034e-06 0.11915967691549265 0.039718204151578826 6.618408561910276e-11 10.179246426854865 -0.30563386520064284 IGVNQPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGVNQPK 7 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 6635050.0 122150.0 3374700.0 3138200.0 False True 167312.15597963062 3225594.5953594455 2397021.793257775 1.0 19.2789016223791 14.326644583730065 17.352182741895746 -9.544485291542603 9.388998150667343 0.999971250062373 16.802773103054587 0.9313980685472308 2.02175047003426 0.0 0.0 1.9575514751266285 0.6525171583755427 2.854399183441844e-10 9.544485291542603 15.802801852992214 IGYHLLYYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGYHLLYYLR 10 0 Q68E01-4;Q68E01-3;Q68E01-2;Q68E01 Q68E01-4 INTS3 Integrator complex subunit 3 0 13690600.0 2904500.0 2453300.0 8332800.0 False True 4406338.847392797 2015489.4472796107 6685818.427604015 1.0 0.4574068216456307 1.5173182678767367 22.07114901185646 -6.7675454633977195 1.5837804166754803 0.6878077601389715 1.5227437040792218 0.7211025157913458 0.22853746785981796 0.2704207938386563 1.3382802236109281 0.11376385884217058 0.27142715876941675 1.7078689252748872e-07 6.7675454633977195 0.8349359439402503 IGYHLLYYLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGYHLLYYLR 10 0 Q68E01-4;Q68E01-3;Q68E01-2;Q68E01 Q68E01-4 INTS3 Integrator complex subunit 3 0 13488000.0 2904500.0 5993800.0 4589700.0 False True 3759932.50625445 5660239.761026356 3754421.6942988904 1.0 1.5054099379738453 0.9985343322130403 21.84227533394891 -10.70152333080436 3.7025458945766077 0.9802198787316933 1.2519721350968491 0.24783133825282133 0.20693109954071381 15998055.411873978 47269087.12369094 2055230.0022025807 0.07083801502031317 1.9882759950301745e-11 10.70152333080436 0.2717522563651559 IGYIYALLFVNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGYIYALLFVNK 12 0 O43813;E9PHS0 O43813 LANCL1 LanC-like protein 1 0 41686100.0 8414100.0 13444000.0 19828000.0 False True 12764804.853106478 11044813.161548555 15908987.109078879 1.0 0.8652551518529998 1.2463165157755798 23.605668146366472 -6.81114048790279 1.40980790602358 0.926663125946726 1.253153249388749 0.8627575880922189 0.058449606238986124 0.20525613173542537 0.8038448804817218 0.03259805397410314 0.07536516119632872 1.5447546532052397e-07 6.81114048790279 0.326490123442023 IGYIYALLFVNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGYIYALLFVNK 12 0 O43813;E9PHS0 O43813 LANCL1 LanC-like protein 1 0 24205400.0 8414100.0 6236100.0 9555200.0 False True 10892218.316707041 5889055.553027538 7816251.644631395 1.0 0.5406663162447454 0.7175996126190777 23.37679446845892 -10.097765287785618 5.138037416345533 1.0000085803009977 0.6291329644311876 0.8541868135444018 0.07223271577347923 7.099714307997673e-06 1.246883063031546e-06 0.06994064304413504 0.0233130087698059 7.984260759442224e-11 10.097765287785618 -0.3708756158698101 IGYPKPALLHSTFFPALQGAQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGYPKPALLHSTFFPALQGAQTK 23 1 P23381;P23381-2;H0YJP3 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 21068900.0 9649500.0 4465400.0 6954000.0 False True 9343181.904369256 6248457.506753374 5132538.784471762 1.0 0.6687718991997083 0.5493352090331857 23.155482525671786 -13.999999999999998 0.14195977802315454 2.5851737896803355 0.4049586031192428 0.9995952368199984 0.003835332728887155 11.936523201155957 0.11818669120876645 5.23598398917113 0.12924842894950245 1.0000000000000041e-14 13.999999999999998 -2.180215186561093 IGYPKPALLHSTFFPALQGAQTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGYPKPALLHSTFFPALQGAQTK 23 1 P23381;P23381-2;H0YJP3 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 16829900.0 9649500.0 3385600.0 3794800.0 False True 8023986.795331332 3367361.100811018 4588275.134827232 1.0 0.41966184475406665 0.571819876061719 22.935887801106063 -10.43947062738219 9.166740335631825 1.0000036679767073 0.49574086040808774 0.9360772897622429 0.062118256161696035 4.65659555908812e-06 2.847133050967446e-07 0.06014617990811831 0.02004858096747458 3.6352088970554024e-11 10.43947062738219 -0.5042628075686195 IGYQVTAMIGHTNVVVPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IGYQVTAMIGHTNVVVPR 18 0 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 0 11562600.0 5518500.0 2426800.0 3617300.0 False True 5343318.238174179 3395833.8955948143 2669820.613326106 1.0 0.6355290372439387 0.49965592433783035 22.349304513298122 -13.999999999999998 0.13700765928328565 2.736969682658444 0.32528586845856206 0.9996151285809627 0.004144357561406765 11.932137817775377 0.11574180237439649 5.551081602153805 0.15559228325991534 1.0000000000000041e-14 13.999999999999998 -2.411683814199882 IGYQVTAMIGHTNVVVPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IGYQVTAMIGHTNVVVPR 18 0 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 0 43507000.0 10977000.0 15836000.0 16694000.0 False True 16652911.526194107 13009942.07276727 13394423.58275986 1.0 0.781241289386745 0.8043292346621295 23.989271098396127 -9.884587044550324 5.22634094555652 1.0000003068260037 0.7927852621188393 0.9907750130708523 0.009425614200962251 12842216.058133395 3.876596858008361 47.41229920431935 0.003226638445802233 1.3044065035247548e-10 9.884587044550324 -0.20721504470716445 IGYQVTAMIGHTNVVVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGYQVTAMIGHTNVVVPR 18 0 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 0 7517400.0 0.0 3054200.0 4463200.0 False True 0.0 2919255.345111218 3409084.082489354 0.0 IGYQVTAMIGHTNVVVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGYQVTAMIGHTNVVVPR 18 0 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 0 7777400.0 5518500.0 0.0 2258900.0 False True 4588877.261001706 0.0 2731225.5460264706 1.0 0.0 0.5951838305281391 22.1297097887324 -10.069002490986552 6.546694836209675 1.0000005644596694 0.2975919152640675 0.6499843785315738 0.2429827813248545 2.00182249424978e-06 2.8488623915712887e-07 0.23526725215912994 0.07842235545719214 8.530952208980454e-11 10.069002490986552 -0.702408649195602 IGYQVTAMIGHTNVVVPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IGYQVTAMIGHTNVVVPR 18 0 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 0 38943000.0 10977000.0 15310000.0 12656000.0 False True 14209942.889018815 14457985.041428378 10352737.861526184 1.0 1.0174555347862266 0.7285559092237163 23.760397420488577 -6.892531978290199 1.0072530312453134 1.0145938033815114 0.7024363232344396 0.9824710963383632 0.017511641494829817 0.11711402245340043 0.21002511670874274 0.013200557208182341 0.033224832403178514 1.2807607851455825e-07 6.892531978290199 -0.3121574801470718 IGYSSPLTLSDQSSK(ub)IK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IGYSSPLTLSDQSSKIK 17 1 O60488-2;O60488 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 16557000.0 6033000.0 7673500.0 2850500.0 True False 8263563.135694726 7334459.397128852 2177270.607890286 1.0 0.8875662080256178 0.26347842596924026 22.97833255554236 -6.937504200398932 0.6823893413259638 1.0073993503087886 0.10686033095541163 0.9978183523439806 0.01513188071057812 0.08892399345619344 0.05993489292700254 0.01446478459296134 0.05433102069951907 1.1547708159508248e-07 6.937504200398932 -0.900539019353377 down IGYSSPLTLSDQSSK(ub)IK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IGYSSPLTLSDQSSKIK 17 1 O60488-2;O60488 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 14249000.0 5686000.0 6180300.0 2382700.0 True False 4728160.93250987 6147005.497206492 2880911.553639941 1.0 1.3000838137595816 0.609309115058115 22.172847710715796 -6.788647658246921 1.501804629632016 1.1680143728864263 0.6022420190636616 0.7968769784380156 0.12746241514377885 0.23738192536010141 1.057726299990855 0.06681092257182145 0.1565713354803289 1.6268680934801773e-07 6.788647658246921 -0.5657723538227647 IHALTITWALPPQQQHYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHALTITWALPPQQQHYR 18 0 O43847-2;G3V1R5;O43847;F5H7V1 O43847-2 NRD1 Nardilysin 0 59797000.0 15430000.0 17892000.0 26475000.0 False True 23408438.084100857 14699032.80916593 21242204.645595264 1.0 0.6279373598680894 0.9074592917851741 24.48052533879398 -10.310100906716736 5.67183041603184 1.0000283831316743 0.7676983258266309 0.47941021214835877 0.11411435085231364 4.0961811139851985e-05 4.982486276338185e-06 0.11050422857103441 0.03683024836785568 4.8966503429037895e-11 10.310100906716736 -0.2323300573050434 IHALTITWALPPQQQHYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHALTITWALPPQQQHYR 18 0 O43847-2;G3V1R5;O43847;F5H7V1 O43847-2 NRD1 Nardilysin 0 21189800.0 5473000.0 6576400.0 9140400.0 False True 7496516.002263764 6285832.902753386 6981625.772447063 1.0 0.8385005649097819 0.9313160634004893 22.83778882972334 -10.137929031750936 4.645647784514037 1.000011380611198 0.8849083141576208 0.6721472658412271 0.037891768592877295 4.466851372930295e-06 8.289285125204828e-07 0.03669217431956671 0.012229515725770239 7.278987410668246e-11 10.137929031750936 -0.11510306645357726 IHALTITWALPPQQQHYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHALTITWALPPQQQHYR 18 0 O43847-2;G3V1R5;O43847;F5H7V1 O43847-2 NRD1 Nardilysin 0 19129600.0 7616800.0 3688400.0 7824400.0 False True 6333706.681452894 3668529.8571099183 9460445.86406193 1.0 0.579207412280796 1.4936665589148803 22.59461862598428 -6.7815750405935695 1.5296224899475022 0.7622255778510724 1.5012861562545066 0.7729634536494738 0.1780720490835624 0.24813302234718745 1.1468083649581244 0.09168005687102573 0.2160534988282015 1.6535790425414314e-07 6.7815750405935695 0.7390605784034342 IHALTITWALPPQQQHYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHALTITWALPPQQQHYR 18 0 O43847-2;G3V1R5;O43847;F5H7V1 O43847-2 NRD1 Nardilysin 0 53022000.0 15430000.0 19393000.0 18199000.0 False True 19974439.170771644 18313762.50218294 14886968.737509077 1.0 0.9168599100885519 0.7453009624066441 24.25165166088643 -6.959428985515043 0.4434084458767813 1.005920723110024 0.6495133242675102 0.9997484273663408 0.0016820279762885134 0.07990574011848488 0.021889821856213982 0.0022718406030647394 0.01420589942756992 1.0979208041967872e-07 6.959428985515043 -0.3564073988425138 IHAYSQLLESYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHAYSQLLESYR 12 0 Q15008;Q15008-4;Q15008-3;Q15008-2 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 0 9948000.0 2518900.0 3279600.0 4149500.0 False True 3302302.2930622967 2790296.463780672 3720149.5448146225 1.0 0.8449548878801066 1.1265321023548232 21.655040760059954 -6.757227986641094 1.6230201492207237 0.9096308845982314 1.127418137738292 0.6795055032040194 0.06518881856415429 0.2875990159588627 1.492500917545675 0.03170131706172343 0.07638974028603393 1.7489283325552838e-07 6.757227986641094 0.21778725314006053 IHAYSQLLESYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHAYSQLLESYR 12 0 Q15008;Q15008-4;Q15008-3;Q15008-2 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 0 9520500.0 2518900.0 2764400.0 4237200.0 False True 3450205.400712984 2642259.6673516617 3236460.627873255 1.0 0.765826772749715 0.938048681740641 21.718250821582846 -10.204449487485642 5.4827987539788525 1.0000064357744693 0.851937727386937 0.49634514817989583 0.07030929992601809 5.531439987001674e-06 8.025894733322249e-07 0.06807964565011121 0.022692228974740356 6.245259842755538e-11 10.204449487485642 -0.1480687083875324 IHETIESINQLK(ub)TQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHETIESINQLKTQR 15 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 12527600.0 1521200.0 3485800.0 7520600.0 True False 1994307.9313217544 2965732.2275419747 6742440.454689205 1.0 1.4870984470168536 3.380842220399014 20.927456755736188 -6.945528629188246 0.6059493295174672 0.9789180826617176 3.9869594461169497 0.9988020212351868 0.03554518614512377 0.08533247147105821 0.04378708950400162 0.036270782588404334 0.15946145221844144 1.1336301054509597e-07 6.945528629188246 3.008041363455232 up IHETIESINQLK(ub)TQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHETIESINQLKTQR 15 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 18036600.0 3213300.0 4027500.0 10795800.0 True False 3111295.550371492 5635701.753135037 7968056.112942228 1.0 1.8113681782697013 2.5610090664613443 21.569084016206343 -6.972074384864611 0.20260281641789682 0.5685101042013336 3.8246233784049406 0.9999943622210083 0.001513539698233008 0.07563514582466811 0.006562854945035661 0.0238249594143868 0.07906727552324472 1.0664134529779361e-07 6.972074384864611 3.256113274203607 IHETIESINQLK(ub)TQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHETIESINQLKTQR 15 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 41220500.0 7723900.0 5391600.0 28105000.0 True False 11717720.992727585 4429426.855236929 22550034.431140903 1.0 0.37801095093371667 1.9244385870884124 23.48218866808379 -6.797536097836839 1.4659059403922947 0.6557366303978714 1.9445186473094997 0.8248621211347613 0.2658858597884951 0.22430114629586273 0.9518080768997262 0.14270664038783054 0.33240025680896595 1.5939103920186943e-07 6.797536097836839 1.2887820169116284 IHETIESINQLK(ub)TQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHETIESINQLKTQR 15 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 10520700.0 1521200.0 1982000.0 7017500.0 True False 2083628.7488842723 1894428.686402475 5360111.029949155 1.0 0.9091968458473666 2.5724885168815947 20.99066681725908 -6.893991949158276 0.9984507105221022 0.9189929246125259 2.7272667418320222 0.9833333735359585 0.09857777392000658 0.11596462741848919 0.2033977176787902 0.07480418242926305 0.18938114063598546 1.2764624713318211e-07 6.893991949158276 1.8082738172194963 up IHETIESINQLK(ub)TQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHETIESINQLKTQR 15 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 12812400.0 3213300.0 2819800.0 6779300.0 True False 2672001.323326406 2804609.1777135227 8196820.286058368 1.0 1.049628663440193 3.0676707434613277 21.34948929164062 -6.912186777816501 0.8806960143113381 0.9417552376806987 3.3410596334893805 0.9917212814654569 0.08764138653259472 0.10299008313570493 0.13104943581679981 0.07253810620765293 0.20340987477717928 1.2240896395897094e-07 6.912186777816501 2.3993043958086817 up IHETIESINQLK(ub)TQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHETIESINQLKTQR 15 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 67862700.0 7723900.0 3450800.0 56688000.0 True False 9998740.810831051 3258759.946503011 46371365.667999074 1.0 0.32591703377019104 4.637720543547612 23.25331499017624 -6.866944163507719 1.1500716369457975 0.6249400108502863 4.8760688188721915 0.961540603940823 0.37139866199784854 0.13982218769738358 0.34755331720205745 0.2510509922907868 0.5914467825907286 1.3584880938303884e-07 6.866944163507719 4.251128808021905 up IHEVQEEMK(ub)NK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHEVQEEMKNK 11 1 O95155-3;O95155-2;O95155;O95155-4;K7ERA7 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 5104700.0 1417900.0 1960000.0 1726800.0 True False 1858880.6309631327 1667575.6400201614 1548127.3006352305 1.0 0.8970859194741023 0.8328277108536587 20.826002699104546 IHEVQEEMK(ub)NK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHEVQEEMKNK 11 1 O95155-3;O95155-2;O95155;O95155-4;K7ERA7 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 5952600.0 1372200.0 1504700.0 3075700.0 True False 1328640.2621043045 2105534.5569068408 2270081.900977831 1.0 1.5847288517149771 1.7085752748320815 20.341519107849457 -11.450610325614443 0.2730045028776352 7.961253805085883e-09 1.7543545453744787 0.9993165946252294 0.00807786282059282 3.8233062887436464 0.148700178862279 2.316562838964309 0.050508654231301485 3.5431511072180593e-12 11.450610325614443 1.7543545374132248 IHEVQEEMK(ub)NK ddPTM_RPMI8226_Bortezomib_8h_R1 2 IHEVQEEMKNK 11 1 O95155-3;O95155-2;O95155;O95155-4;K7ERA7 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 21398890.0 4069100.0 8207390.0 9122400.0 True False 6173122.191057334 6742717.129869245 7319353.641510034 1.0 1.0922701545802953 1.1856809917213664 22.55756891773801 -6.970972311007332 0.23379821689099006 0.9637700824396204 1.3168623706752958 0.9999889993660626 0.000251355779547005 0.07598844008281437 0.007892194256541925 0.0023343897395000893 0.009210495354777762 1.0691230403381974e-07 6.970972311007332 0.3530922882356754 IHEVQEEMK(ub)NK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHEVQEEMKNK 11 1 O95155-3;O95155-2;O95155;O95155-4;K7ERA7 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 4191300.0 1417900.0 0.0 2773400.0 True False 1942135.9473067392 0.0 2118380.0399659397 1.0 0.0 1.090747557040797 20.889212760627437 -10.43610203130544 4.339243724037895 1.0016246647555502 0.5453737785189147 0.18806938971293496 0.4452958254945439 0.007022007313910975 0.0009125310015522076 0.4325810133083507 0.1437186096889735 3.663514954686038e-11 10.43610203130544 -0.45625088623663557 IHEVQEEMK(ub)NK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHEVQEEMKNK 11 1 O95155-3;O95155-2;O95155;O95155-4;K7ERA7 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 5334600.0 1372200.0 2063700.0 1898700.0 True False 1141045.0987671537 2052582.4384876199 2295709.391403096 1.0 1.7988617984559419 2.011935719178412 20.121924383283734 -10.835977125242332 0.2613548726779219 2.7344947352963265e-14 2.1064593520503307 0.9991923786012267 0.012378698613032195 2.6584320185130035 0.1349446027989099 1.7344810944066105 0.09165901588528425 1.4588910996157274e-11 10.835977125242332 2.106459352050303 IHEVQEEMK(ub)NK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHEVQEEMKNK 11 1 O95155-3;O95155-2;O95155;O95155-4;K7ERA7 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 15229600.0 2128900.0 5459500.0 7641200.0 True False 2755903.0168927927 5155674.025713792 6250580.005332951 1.0 1.870774840083697 2.2680696552160655 21.39409368831351 -9.893521327896622 0.1946742346438811 2.8003360020482215e-13 2.6482099774119496 0.9994650587989151 0.012248541183495188 1.386701266677709 0.08702116589126496 0.9921982993204691 0.24557079761811526 1.277846453884555e-10 9.893521327896622 2.6482099774116694 IHFELGKPFKPFEQLLAVLPAASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHFELGKPFKPFEQLLAVLPAASK 24 2 Q8IZH2-2;Q8IZH2 Q8IZH2-2 XRN1 5-3 exoribonuclease 1 0 96222300.0 31655300.0 22803000.0 41764000.0 False True 48023404.412419826 18733626.4893478 33509327.094188537 1.0 0.3900936786668732 0.6977707537436131 25.517234345056423 -10.547191368362178 6.462336861087248 1.0005405395601574 0.5439322162052866 0.745520701916365 0.12560863991500068 0.0009793200890136696 6.861966316152629e-05 0.12175628199841589 0.04054001421088014 2.8366687977731773e-11 10.547191368362178 -0.4566083233548708 IHFELGKPFKPFEQLLAVLPAASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHFELGKPFKPFEQLLAVLPAASK 24 2 Q8IZH2-2;Q8IZH2 Q8IZH2-2 XRN1 5-3 exoribonuclease 1 0 61737400.0 31655300.0 22514000.0 7568100.0 False True 40978409.86925001 21261076.108603455 6190783.455263613 1.0 0.5188360450403338 0.1510742724038481 25.288360667148872 -8.057224007557299 0.3538513269200674 1.0894035679784158 3.741003651079413e-15 0.9983432224036769 0.014148615347898888 0.09472088795727183 0.07636053557797766 0.05617230793971442 0.08622691892357537 8.765485838640039e-09 8.057224007557299 -1.089403567978412 down IHFFLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHFFLSK 7 0 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2;A0A494C198;D6R9L5 H0Y993 DEK Protein DEK 0 170939000.0 51999000.0 43206000.0 75734000.0 False True 68171192.55903228 36759833.215668924 67897772.17182566 1.0 0.5392282551583215 0.9959892092694455 26.022658885393962 -10.936689651919433 10.310058814067993 1.0516995059540646 0.7676087322138835 0.25658520181080957 0.18647187866650933 0.10827921645440876 0.0006649028192545794 0.08822290401787568 0.06018354005095002 1.1569386985702968e-11 10.936689651919433 -0.2840907737401811 IHFFLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHFFLSK 7 0 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2;A0A494C198;D6R9L5 H0Y993 DEK Protein DEK 0 161232000.0 66758000.0 22924000.0 71550000.0 False True 64638803.83148171 32077672.74708074 52808908.54601021 1.0 0.4962603087567907 0.8169846193887972 25.945897164863794 -10.087357355895609 5.187603818332618 1.0000063291212318 0.6566224640722 0.604482888821309 0.13093515152779883 9.584631705003331e-06 1.6864986299049697e-06 0.12677975146248638 0.04225913844139303 8.177915976412904e-11 10.087357355895609 -0.34338386504903173 IHFFLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHFFLSK 7 0 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2;A0A494C198;D6R9L5 H0Y993 DEK Protein DEK 0 98707100.0 31039000.0 24335000.0 43333100.0 False True 47088432.25485463 19992229.119777177 34768293.791427605 1.0 0.4245677369672051 0.7383616766693933 25.488869355084322 -10.125861833443398 5.436373693633467 1.0000074061133173 0.5814647068181826 0.7034396718686085 0.12810583944181275 1.149947215683551e-05 1.8489277329578693e-06 0.12404013855166272 0.041345981892436566 7.484075612121069e-11 10.125861833443398 -0.41854269929513466 IHFFLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHFFLSK 7 0 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2;A0A494C198;D6R9L5 H0Y993 DEK Protein DEK 0 181822000.0 51999000.0 42268000.0 87555000.0 False True 71224435.52013758 40400459.99841563 66876312.25182726 1.0 0.5672275210519996 0.9389518044396301 26.085868946916854 -10.136244608714325 7.530603274471858 1.0000000772574023 0.7530896627458149 0.3703834382702407 0.1517558032169047 1.9678528631855496e-07 2.2678595945737893e-08 0.14693697061724206 0.04897897487911684 7.307273982260027e-11 10.136244608714325 -0.24691041451158735 IHFFLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHFFLSK 7 0 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2;A0A494C198;D6R9L5 H0Y993 DEK Protein DEK 0 129959000.0 66758000.0 37216000.0 25985000.0 False True 55512234.88084659 37015510.02120237 31418343.35893483 1.0 0.6667991317707486 0.5659715092784909 25.72630244029807 -13.999999999999998 0.16747339761688032 2.6695184075545706 0.47459480094719747 0.999518727814734 0.004068674565183062 12.06795179461971 0.12953813766711578 6.544085876836383 0.08413380026973939 1.0000000000000041e-14 13.999999999999998 -2.194923606607373 IHFFLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHFFLSK 7 0 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2;A0A494C198;D6R9L5 H0Y993 DEK Protein DEK 0 128926000.0 31039000.0 54642000.0 43245000.0 False True 40180597.37016082 51601124.66582159 35374853.73117098 1.0 1.284229903066149 0.8803964113644883 25.25999567717677 -6.717604073164602 1.7683753514854146 1.1733671020572718 0.8811274787171158 0.5010063303578746 0.11964148527616626 0.3599840191266839 2.198802066254904 0.05375263126318364 0.13529857943731513 1.916001862170417e-07 6.717604073164602 -0.29223962334015596 IHFIK(ub)NMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHFIKNMR 8 1 Q8TDN4-2;Q8TDN4;V9GYB4 Q8TDN4-2 CABLES1 CDK5 and ABL1 enzyme substrate 1 1 2082070.0 477650.0 721850.0 882570.0 True False 654250.1130058988 689956.2801612637 674125.1430997113 1.0 1.0545757141581769 1.0303783365087984 19.319482742900853 -10.045943914244695 4.655991632957918 0.9999984651125501 1.0424770253349973 0.8042575669629616 0.009878538064233713 1.5740815572352248e-07 3.223636002217315e-08 0.009565198989204497 0.003188284449907492 8.996137521493856e-11 10.045943914244695 0.042478560222447226 IHFIK(ub)NMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHFIKNMR 8 1 Q8TDN4-2;Q8TDN4;V9GYB4 Q8TDN4-2 CABLES1 CDK5 and ABL1 enzyme substrate 1 1 4261380.0 871280.0 1947600.0 1442500.0 True False 724507.9242485402 1937107.892231669 1744120.0806335737 1.0 2.6736876539215744 2.407316776338334 19.466641943669053 -10.163563334958178 4.73621792595834 0.999831688060815 2.5405022151403247 0.978067955222014 0.1087454554383232 38086310.77455066 22.692800500886293 69908.87372851411 0.03722646185073536 6.861778029711325e-11 10.163563334958178 1.5406705270795098 IHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHFISPNIYCCGAGTAADTDMTTQLISSNLELHSLSTGR 39 0 Q99436;Q5TBG5;Q99436-2 Q99436 PSMB7 Proteasome subunit beta type-7;Proteasome subunit beta type 0 82210000.0 17502000.0 45513000.0 19195000.0 False True 26551813.567591276 37390849.55530796 15401099.83653264 1.0 1.4082220583586291 0.5800394687664943 24.66230706895522 -6.772657459182096 1.5641209567900811 1.2333461448628253 0.5748870378252151 0.7406918583277284 0.17217618798278592 0.26214602370638707 1.2660201120258232 0.0867450887895219 0.20600362517631865 1.6878837840478004e-07 6.772657459182096 -0.6584591070376102 IHFPLATYAPVISAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHFPLATYAPVISAEK 16 0 F8VVB9;P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 232956450.0 51577500.0 97775600.0 83603350.0 False True 67618601.9772205 83187861.60630363 74952877.32196109 1.0 1.2302511316978741 1.108465350218441 26.010916852856596 -10.155829190758029 3.899623699831334 0.9999143536839925 1.169358240954124 0.7205491698405051 0.04971883736508424 15466627.27487348 17957418.294111367 14603.008438742108 0.018195232107321192 6.985070748575912e-11 10.155829190758029 0.1694438872701316 IHFPLATYAPVISAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHFPLATYAPVISAEK 16 0 F8VVB9;P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 199809000.0 64902100.0 34712200.0 100194700.0 False True 62841818.36111342 48572962.48173163 73950702.29343025 1.0 0.7729401177192643 1.1767753419940983 25.9052215905885 -6.754161114868483 1.6346280409259455 0.8671565421039062 1.177830850445012 0.6666145993627045 0.09543797825329482 0.29283819099654285 1.54072039792464 0.04609997892453423 0.11142571777746164 1.7613225085468273e-07 6.754161114868483 0.31067430834110565 IHFPLATYAPVISAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHFPLATYAPVISAEK 16 0 F8VVB9;P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 210988300.0 27857300.0 170344000.0 12787000.0 False True 42261560.74142731 139944782.29625314 10259643.845258798 1.0 3.311396452026224 0.24276537982189764 25.332842711946743 -6.705165207985988 1.812517498105558 2.42789095310848 0.25091299325778765 0.44226136981557074 0.9747650521539062 0.38477501458877206 2.460958345052165 0.4284854377455573 1.0949521939301143 1.9716725584595373e-07 6.705165207985988 -2.176977959850692 IHFPLATYAPVISAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHFPLATYAPVISAEK 16 0 F8VVB9;P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 228464900.0 51577500.0 86081800.0 90805600.0 False True 70647095.5795284 82278421.44155414 69359187.48003578 1.0 1.1646398307901022 0.9817698365526887 26.074126914379487 -6.669491834153875 1.9392398386056038 1.1051346624267697 0.9825115022551202 0.2767924307495805 0.06994355749070023 0.4622707234065214 3.351082054113909 0.029041877352216416 0.07764223293384977 2.1404651726085976e-07 6.669491834153875 -0.12262316017164954 IHFPLATYAPVISAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHFPLATYAPVISAEK 16 0 F8VVB9;P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 143991900.0 64902100.0 35234600.0 43855200.0 False True 53968971.80053617 35044784.21627948 53025119.556465514 1.0 0.649350599929927 0.9825112057431993 25.685626866022776 -10.60493534934816 9.139913044010449 1.0000450945781036 0.8159309032020244 0.2892673801223101 0.13601224777317333 0.00012501219919469522 5.403540458953817e-06 0.13172543830227268 0.04389776420881142 2.483502781011342e-11 10.60493534934816 -0.1841141913760792 IHFPLATYAPVISAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHFPLATYAPVISAEK 16 0 F8VVB9;P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 82612600.0 27857300.0 35175300.0 19580000.0 False True 36061823.99947747 33217763.633426268 16016640.907765694 1.0 0.9211337627821485 0.4441439486809589 25.103969034039192 -6.935665890614933 0.6987179258035113 1.005960117685729 0.33041127216909744 0.9975393582232207 0.012181165734461 0.08980061784583082 0.06403706322516803 0.01149905727451299 0.041896843015116085 1.1596691642891566e-07 6.935665890614933 -0.6755488455166314 down IHFPLATYAPVISAEK(ub)AYHEQLSVAEITNACFEPANQMVK ddPTM_RPMI8226_Bortezomib_8h_R1 2 IHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVK 40 1 P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2 P68363;P68366-2;Q71U36 TUBA1B;TUBA4A;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain 1 453031000.0 115466000.0 92207000.0 245358000.0 True False 175170363.69532016 75751940.43342082 196862883.75576833 1.0 0.43244724070550417 1.1238367016134003 27.38418347144409 -6.688526764936043 1.8713014701587054 0.6437034455110537 1.1214305016864985 0.3637372899419802 0.2401050279626548 0.41981960778930144 2.8490353419250165 0.10268184190683668 0.2679227087335066 2.0486757891634627e-07 6.688526764936043 0.47772705617544475 IHFPLATYAPVISAEK(ub)AYHEQLSVAEITNACFEPANQMVK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVK 40 1 P68363;P68363-2;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2 P68363;P68366-2;Q71U36 TUBA1B;TUBA4A;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain 1 382430000.0 115466000.0 40925000.0 226039000.0 True False 149473013.1751341 38647487.774033725 184902221.3559987 1.0 0.2585582972676904 1.2370274568517128 27.15530979353654 -6.704119793158202 1.8167316334280987 0.5414511153825788 1.2342986457155791 0.43691923906391217 0.31274328340307406 0.38700184072214466 2.486142098938414 0.1372058572320759 0.35100148201791387 1.9764243999874628e-07 6.704119793158202 0.6928475303330003 IHIFAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHIFAQK 7 0 P14373;P14373-2 P14373 TRIM27 Zinc finger protein RFP 0 4612100.0 1187500.0 1056200.0 2368400.0 False True 1556823.999766358 898619.0770353553 2123340.687297015 1.0 0.5772130164811285 1.3638925707823606 20.57017442509863 -6.760719727138055 1.609666933284662 0.7546411410638415 1.3668781877711906 0.6939258101290116 0.17784468696714223 0.28171502594665015 1.4387696170857025 0.08716523234514176 0.20933105415652578 1.734923272953615e-07 6.760719727138055 0.6122370467073491 IHIFAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHIFAQK 7 0 P14373;P14373-2 P14373 TRIM27 Zinc finger protein RFP 0 3707160.0 1187500.0 965260.0 1554400.0 False True 1626550.840980853 922611.6215120341 1187282.733872885 1.0 0.5672196640073512 0.729938901360699 20.633384486621523 -10.107464486904322 4.9571778103290285 1.0000132242215478 0.6485792826825449 0.8614753118564807 0.06642985048021281 92550182.40621509 1.6743892814189871 13970.095115210815 0.02274070474904072 7.80792284415436e-11 10.107464486904322 -0.35143394153900287 IHIFFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHIFFR 6 0 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 55176300.0 12446000.0 17802000.0 24928300.0 False True 16316826.527235435 15146010.991652492 22348958.64513855 1.0 0.9282448989925424 1.3696878254993092 23.959857157880332 -6.865225021467435 1.159143211983728 0.9603865023002328 1.3932900205854342 0.9596759743816027 0.038839678196415074 0.14151063014109733 0.35838904613138034 0.026074028030852393 0.06126523915026364 1.3638762867956002e-07 6.865225021467435 0.43290351828520135 IHIFFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHIFFR 6 0 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 33715200.0 8258200.0 6575000.0 18882000.0 False True 7996047.961310134 9200431.78817204 13936237.752142068 1.0 1.1506223865451366 1.7428907154602218 22.930855694900558 -6.94526874712305 0.6085844652730575 0.9934350852601356 1.9308461498209224 0.9987756439676552 0.011219844913345642 0.08544323752992675 0.04426836878760942 0.011420060524246134 0.049916743775378865 1.1343086733588502e-07 6.94526874712305 0.9374110645607868 IHIFFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHIFFR 6 0 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 56917000.0 12446000.0 17955000.0 26516000.0 False True 17047622.540503316 17161688.730755 20253466.914162006 1.0 1.0066910321354592 1.188052285064498 24.023067219403224 -6.914705680585229 0.8630718547504388 0.9951853994641229 1.2140120102077896 0.9925795497298531 0.007504213247344081 0.10138798854910928 0.12249564415318279 0.00629049261827265 0.017986610461948646 1.2170104837652518e-07 6.914705680585229 0.21882661074366672 IHIFFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHIFFR 6 0 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 20327200.0 8258200.0 3925600.0 8143400.0 False True 6867059.200290707 3904452.013629405 9846147.28917259 1.0 0.5685770137913061 1.4338229804041542 22.711260970334834 -6.771148610354442 1.5702406511241043 0.7529114673802851 1.438882007393989 0.7348855211475065 0.18187844748441118 0.26456764898721724 1.287589557977617 0.09129374394410902 0.21707251702757918 1.6937581175923411e-07 6.771148610354442 0.6859705400137038 IHIK(ub)RPDDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHIKRPDDR 9 2 Q9H3F6;F5GWA4;Q9H3F6-2;B3KVY5;Q9H3F6-3 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 4276100.0 1620600.0 1630700.0 1024800.0 True False 1569154.9400715888 2281847.0139881615 756374.1366589977 1.0 1.4541884652155879 0.48202641902557436 20.58155638194675 -6.779670982308818 1.537242543624139 1.2572819268078577 0.47441669285054017 0.7661985526942502 0.1920427908555918 0.2510837520759451 1.1719547365770937 0.09839926930914675 0.23223616550638862 1.6608446723014554e-07 6.779670982308818 -0.7828652339573174 down IHIK(ub)RPDDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHIKRPDDR 9 2 Q9H3F6;F5GWA4;Q9H3F6-2;B3KVY5;Q9H3F6-3 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 4638700.0 1620600.0 2362300.0 655800.0 True False 1347600.7047529863 2349573.8210201655 792924.7479233965 1.0 1.7435237401800259 0.5883973977801821 20.361961657381027 -6.732915199135721 1.712719822016573 1.4459988745954397 0.5887290502766 0.5726468776886564 0.31249494506625985 0.3308149412119503 1.902441162306924 0.1445151866932916 0.35741089858324826 1.8496297446545392e-07 6.732915199135721 -0.8572698243188397 IHIPFISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHIPFISK 8 0 B4DIH5;P61201;P61201-2;H0YMC2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 0 18662800.0 6381600.0 3402500.0 8878700.0 False True 8366339.399502313 2894860.262841122 7960017.294504312 1.0 0.34601276909867273 0.9514337052806904 22.99616509468442 -10.74409022220737 9.930310376593088 1.0010101500740027 0.6487232371896879 0.30980800122488217 0.24716206220734022 0.005540489737863891 0.00014278124038144424 0.23987387438410818 0.07977121256194254 1.8026432130878833e-11 10.74409022220737 -0.3522869128843148 IHIPFISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHIPFISK 8 0 B4DIH5;P61201;P61201-2;H0YMC2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 0 13915200.0 4050700.0 2445200.0 7419300.0 False True 3922112.745741077 3421581.111549548 5475962.755770986 1.0 0.8723821402801224 1.3961767829640277 21.903199577415077 -6.842312531419677 1.271641233733633 0.9321184225564584 1.414205479340137 0.9283535802994412 0.059692885927376024 0.16611478172744892 0.5207977486784612 0.03679388251896951 0.08482446650950788 1.437763547828661e-07 6.842312531419677 0.4820870567836787 IHIPFISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHIPFISK 8 0 B4DIH5;P61201;P61201-2;H0YMC2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 0 18296800.0 6381600.0 4988700.0 6926500.0 False True 8741049.976255512 4768282.738575183 5290603.35574532 1.0 0.5455045734240063 0.6052594791377348 23.059375156207313 -10.296337336635895 5.631553912154354 1.0000462683645581 0.5753820262811259 0.9853644661524829 0.024394838104479257 1.4172919697661246e-05 1.770929093606423e-06 0.023622765561905987 0.0078734001426699 5.0543191711515186e-11 10.296337336635895 -0.42466424208343223 IHIPFISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHIPFISK 8 0 B4DIH5;P61201;P61201-2;H0YMC2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 0 10647500.0 4050700.0 2827500.0 3769300.0 False True 3368336.526436459 2812267.6962851896 4557443.202725914 1.0 0.8349129234009276 1.3530249032294508 21.683604852849353 -6.820984251231111 1.3675195418999588 0.9111061144065122 1.3645852811331218 0.8866548673782071 0.07275626388658316 0.19220245195087193 0.7059957530774071 0.04180467993662828 0.09633298681252088 1.5101349150131773e-07 6.820984251231111 0.4534791667266096 IHIVMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHIVMK 6 0 B8ZZF8;Q9Y4Y9 B8ZZF8 LSM5 U6 snRNA-associated Sm-like protein LSm5 0 65410000.0 23497000.0 15867000.0 26046000.0 False True 30804794.545271717 13499705.449081594 23351009.770874012 1.0 0.43823390638889 0.7580316673288184 24.8766515777409 -10.216871322572974 5.684624897664117 1.0000142000475087 0.598132786858856 0.6779895572439717 0.13055688919793795 2.3496892082140078e-05 3.2369802842811765e-06 0.12641562624093802 0.042137054799682425 6.069161265704237e-11 10.216871322572974 -0.4018814131886528 IHIVMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHIVMK 6 0 B8ZZF8;Q9Y4Y9 B8ZZF8 LSM5 U6 snRNA-associated Sm-like protein LSm5 0 26822200.0 8626000.0 10279000.0 7917200.0 False True 13086272.64507155 8444632.139806436 6352361.94976796 1.0 0.6453046156719643 0.4854217944297789 23.641550898070385 -13.999999999999542 0.10755799966796026 2.719325681466351 0.18153580825376922 0.9997554761342029 0.0033625594787391575 12.027543942677015 0.09911128975498001 4.512012450762511 0.2701039006400681 1.0000000000010553e-14 13.999999999999542 -2.537789873212582 IHIVMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHIVMK 6 0 B8ZZF8;Q9Y4Y9 B8ZZF8 LSM5 U6 snRNA-associated Sm-like protein LSm5 0 61544000.0 23497000.0 15796000.0 22251000.0 False True 32184475.882549185 15098080.489613261 16995772.073729765 1.0 0.4691106527479487 0.528073600942033 24.939861639263793 -10.139041078039913 5.353099367345152 1.0000117945840008 0.4985921268749185 0.9897350620820057 0.024071522803745946 3.545798209840375e-06 5.70281856671971e-07 0.023307724933288365 0.007769050577645796 7.260372814556436e-11 10.139041078039913 -0.5014196677090823 IHIVMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHIVMK 6 0 B8ZZF8;Q9Y4Y9 B8ZZF8 LSM5 U6 snRNA-associated Sm-like protein LSm5 0 35707200.0 13524000.0 14150000.0 8033200.0 False True 11245805.21478427 14073771.141444895 9712904.978679825 1.0 1.2514685140502742 0.8636913758661565 23.422883627931643 -6.731661625793966 1.7172374608460512 1.151050733114908 0.8638534418392707 0.5669514808603451 0.10569793457107435 0.3331179021881042 1.9252385322983365 0.04876271950838587 0.12077136399940401 1.8549763382637363e-07 6.731661625793966 -0.2871972912756373 IHIVMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHIVMK 6 0 B8ZZF8;Q9Y4Y9 B8ZZF8 LSM5 U6 snRNA-associated Sm-like protein LSm5 0 27083700.0 8626000.0 10931000.0 7526700.0 False True 11166527.043880507 10322680.240878744 6156917.830463749 1.0 0.9244306846984973 0.5513726699688486 23.412677220162834 -6.940091206502022 0.6587243226954831 1.004181080761565 0.4505036528076774 0.9981756837456619 0.008376460618901965 0.08772535047155962 0.054422489131199805 0.008159426326429315 0.032095548201689104 1.1479125222320544e-07 6.940091206502022 -0.5536774279538876 IHLAQSLHK(ub)LSTACPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHLAQSLHKLSTACPGR 17 1 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 1 5870300.0 2077600.0 1787600.0 2005100.0 True False 2845744.865028901 1708617.9211973057 1531536.6763307499 1.0 0.6004114923281969 0.5381848159164457 21.440374892306895 -13.999999999999998 0.26178039997736774 3.9525317805814035 0.5158262489526769 0.9995659878039053 0.0042627926810171095 14.496567524027542 0.1619155991771865 22.666497080284543 0.02695187345537623 1.0000000000000041e-14 13.999999999999998 -3.4367055316287267 IHLDEK(ub)SFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHLDEKSFR 9 1 P37837 P37837 TALDO1 Transaldolase 1 9034700.0 1861300.0 3929700.0 3243700.0 True False 1547753.419570984 3908529.9261156204 3921942.6728257407 1.0 2.5252923861728642 2.533958331626784 20.561744216066177 -10.792490003184053 0.8925575880247909 1.638922793562958e-07 2.531851458070723 0.9999952188041771 0.0015767012045728934 2.646921578107071 0.4989243119189317 5.678450831717193 0.0011888757263530574 1.6125381451510818e-11 10.792490003184053 2.531851294178444 IHLDEK(ub)SFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHLDEKSFR 9 1 P37837 P37837 TALDO1 Transaldolase 1 25519900.0 3916900.0 2755000.0 18848000.0 True False 5070504.26364196 2601681.8281603674 15417857.39681143 1.0 0.5131012011597587 3.0406950857659547 22.273697800276526 -6.85677718464277 1.2018923726859825 0.7377681555668573 3.1557845816518206 0.9496055271141595 0.24580216567868637 0.15015650185783863 0.4140114891846295 0.15970501864565795 0.3715539920527309 1.3906659312097085e-07 6.85677718464277 2.4180164260849635 up IHLQIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHLQIAR 7 0 Q6EEV4-2;Q6EEV4 Q6EEV4-2 POLR2M DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5 0 12740600.0 3094900.0 3660800.0 5984900.0 False True 4057443.871054233 3114622.9096866357 5365639.959214614 1.0 0.7676317920024296 1.3224187763860493 21.952139706608374 -6.792910216815299 1.4845146888386505 0.8706219798906726 1.3288171393966033 0.8106871358799397 0.09897816271436748 0.2310269222893078 1.0056910635472127 0.05247002754573047 0.1225990269955274 1.6109786438840067e-07 6.792910216815299 0.4581951595059307 IHLQIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHLQIAR 7 0 Q6EEV4-2;Q6EEV4 Q6EEV4-2 POLR2M DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5 0 10353500.0 3094900.0 2746500.0 4512100.0 False True 4239168.166527699 2625150.548539047 3446434.909616474 1.0 0.6192607713152618 0.8129979218162151 22.015349768131266 -10.275234393226661 4.7319362299594365 1.0001055776658603 0.7161293465651972 0.7411040427542126 0.07909286049334013 8.812813504488294e-05 1.3498060746699515e-05 0.07660971242365686 0.025527110957602888 5.3059799770802027e-11 10.275234393226661 -0.28397623110066306 IHLQIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHLQIAR 7 0 Q6EEV4-2;Q6EEV4 Q6EEV4-2 POLR2M DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5 0 7347200.0 2739600.0 2476600.0 2131000.0 False True 2278098.7848582543 2463258.0642333883 2576582.247369253 1.0 1.0812779852242689 1.1310230550557845 21.119398877096764 -13.46034581052528 0.04903628232804955 0.4276347270448161 1.4336130978554649 0.9999800370218744 0.00024121975740661622 10.53503447370851 0.04870693093707575 0.8856269420182944 0.2750510550514633 3.4646086829691336e-14 13.46034581052528 1.0059783708106487 IHLVSEPSITHFLQVSWEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHLVSEPSITHFLQVSWEK 19 0 Q13426-3;Q13426-2;Q13426 Q13426-3 XRCC4 DNA repair protein XRCC4 0 22228300.0 8227000.0 4377700.0 9623600.0 False True 12480960.474264264 3596465.2318737824 7721491.2418262735 1.0 0.28815612702962184 0.6186616212548695 23.573225625506193 -10.56843530755646 6.46169526863709 1.0008892483032266 0.45340887414333486 0.7847960312148726 0.13492830300637149 0.0017310279662339132 0.00011561238483072727 0.1308333241573144 0.04354792253964207 2.7012494560874242e-11 10.56843530755646 -0.5474803741598917 IHLVSEPSITHFLQVSWEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHLVSEPSITHFLQVSWEK 19 0 Q13426-3;Q13426-2;Q13426 Q13426-3 XRCC4 DNA repair protein XRCC4 0 18265400.0 8227000.0 4522500.0 5515900.0 False True 10650013.67841466 4270818.899402996 4512062.797913425 1.0 0.4010153440515338 0.42366732420808323 23.344351947598643 -10.103600447075696 5.056951201986717 1.000017064063103 0.4123413341285281 0.9988868856031305 0.00924763218050462 5159962.067095308 10309412.258197848 668.2644915540392 0.0031657116863468312 7.877702086311088e-11 10.103600447075696 -0.587675729934575 IHMGSCAENTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHMGSCAENTAK 12 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 9323570.0 666670.0 3833500.0 4823400.0 False True 874010.8260414643 3261556.7428659606 4324320.83731988 1.0 3.7317120631538123 4.947674226079584 19.737291624391062 -8.985142643104357 0.31533319098352347 1.5552765682507784e-18 5.433326819930254 0.9984620580328727 0.06473702725169411 0.45376510142989845 0.10953867091322413 0.942702133159431 0.3915984270829834 1.0348022322517157e-09 8.985142643104357 5.433326819930254 IHMGSCAENTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHMGSCAENTAK 12 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 5528790.0 2872400.0 635690.0 2020700.0 False True 2781217.2342722644 889524.3320795561 1491418.0502994093 1.0 0.31983274126097155 0.5362465153462401 21.407285003892778 -10.226633102609872 4.976384933924523 1.0000810577534813 0.428039628303046 0.9030372652176222 0.0883505533050834 7.94658107286542e-05 1.2349596791991598e-05 0.08555710322725273 0.028515018464622552 5.934264469301446e-11 10.226633102609872 -0.5720414294504353 IHMGSCAENTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHMGSCAENTAK 12 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 10079070.0 666670.0 5110700.0 4301700.0 False True 913155.9150793318 4884892.375175136 3285727.0562924487 1.0 5.349461460533553 3.5982103406809736 19.800501685913954 -9.358642701808737 11.405169025530412 1.0000218804159913 4.473835900607264 0.8399075030581195 0.7149452759643475 0.0 0.0 0.6922427867644668 0.23074759558815558 4.378822068550239e-10 9.358642701808737 3.4738140201912726 IHMVYSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHMVYSK 7 0 P08621-2;P08621;P08621-3;M0QYR1 P08621-2 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 0 4108530.0 833730.0 640700.0 2634100.0 False True 807263.6975107279 896534.8512063619 1944150.1886938587 1.0 1.1105848732835502 2.408321090975384 19.622680489883557 -6.923715870039662 0.7966612407226504 0.975017767105601 2.6366056852422997 0.9951529221071881 0.04451700385005104 0.09603409014472097 0.0946372306064855 0.0391314046089716 0.12173044352447752 1.1920216133439036e-07 6.923715870039662 1.6615879181366986 up IHNAENIQPGEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHNAENIQPGEQK 13 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 5657010.0 1220400.0 710710.0 3725900.0 False True 1181659.0700131862 994500.2093036892 2749975.015395938 1.0 0.8416134861069459 2.3272152562288975 20.172382421295286 -6.880526418443136 1.0768266197140492 0.9011276219881007 2.4335812431984576 0.9741089598011548 0.1071854251391402 0.12716626589906332 0.26945931468245676 0.07663815148403982 0.18558601213169446 1.3166598169296059e-07 6.880526418443136 1.5324536212103568 up IHNAENIQPGEQK(ub)YEYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHNAENIQPGEQKYEYK 17 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 9183800.0 2894900.0 3930300.0 2358600.0 True False 3795241.93425148 3343914.560189409 2114554.6972887777 1.0 0.881080736911945 0.557159394294536 21.855760424983256 -6.953599054506345 0.517829470157184 1.0055980544537169 0.4182401219214245 0.9994542831189028 0.004371572510357031 0.08207196965881236 0.0302246965853487 0.004969720166053783 0.026750548294002963 1.1127585642918485e-07 6.953599054506345 -0.5873579325322924 IHNAENIQPGEQK(ub)YEYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHNAENIQPGEQKYEYK 17 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 16417700.0 3478100.0 3542500.0 9397100.0 True False 3367689.619315687 4957038.723893448 6935717.603042797 1.0 1.4719404945936543 2.05948836949295 21.683327748907733 -6.968168972711213 0.2987031843717724 0.8965163010086319 2.653288971324617 0.9999643694093973 0.0025869682721557435 0.0769014509643154 0.011145527607832929 0.00981085265421408 0.05276740392778879 1.0760464704201698e-07 6.968168972711213 1.7567726703159852 IHNAENIQPGEQK(ub)YEYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHNAENIQPGEQKYEYK 17 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 72636100.0 9657100.0 17973000.0 45006000.0 True False 14650526.728578778 14765577.726310046 36110544.373169445 1.0 1.0078530280762423 2.4647949553055057 23.8044491988282 -6.90808271836025 0.9086929407142055 0.9521094954302403 2.645557771990188 0.9901776878590411 0.0682521632077372 0.10569953078920764 0.14574584764051787 0.05535455939225738 0.15084788755371584 1.2357120498195133e-07 6.90808271836025 1.6934482765599477 up IHNAENIQPGEQK(ub)YEYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHNAENIQPGEQKYEYK 17 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 10392100.0 2894900.0 2937900.0 4559300.0 True False 3965222.7617309256 2808093.8636638895 3482487.241730984 1.0 0.7081806073457728 0.8782576543595713 21.918970486506147 -10.219381037619696 5.273204725047117 1.0000158178034981 0.793219131345839 0.6634034333146897 0.06943366369069248 1.2912981142657285e-05 1.9115567040898225e-06 0.0672339957622634 0.022409618594994102 6.03418974421611e-11 10.219381037619696 -0.20679668645765914 IHNAENIQPGEQK(ub)YEYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHNAENIQPGEQKYEYK 17 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 15267700.0 3478100.0 7587200.0 4202400.0 True False 2892194.2559554297 7546326.247658712 5081102.410297766 1.0 2.609204493135196 1.756833034238648 21.46373302434201 -9.925936950023972 5.227352297755571 0.9999971260072574 2.183018763052286 0.7197630749240238 0.3479791909760441 119024557.82089911 4.1600153873254975 4117.242084523002 0.11912253276867044 1.1859409081219163e-10 9.925936950023972 1.1830216370450284 IHNAENIQPGEQK(ub)YEYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHNAENIQPGEQKYEYK 17 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 89055100.0 9657100.0 16263000.0 63135000.0 True False 12501306.319900129 15357949.753674066 51645077.81980525 1.0 1.2285075943804853 4.131174494748149 23.575575520920648 -6.92258964887275 0.8052907284323163 0.9417327427879709 4.628314788935085 0.9948704410832756 0.10207748227834612 0.09667210809776942 0.0978948556578865 0.08917824053033524 0.27411729359047154 1.1951167992304562e-07 6.92258964887275 3.686582046147114 up IHPELLAKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHPELLAKK 9 1 Q9P0M6 Q9P0M6 H2AFY2 Core histone macro-H2A.2 1 11616300.0 3353300.0 4764300.0 3498700.0 True False 4396208.773403398 4053485.0110959415 3136688.0859002112 1.0 0.9220410631130853 0.7134984363974808 22.067828469988438 -6.953995754283921 0.5131056077001462 1.0037421317531525 0.6225997056339151 0.999478693702924 0.0027614423570571584 0.0819198265422917 0.029620869612777927 0.003163853002629008 0.017215346174217973 1.1117425957603296e-07 6.953995754283921 -0.38114242611923743 IHPELLAKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHPELLAKK 9 1 Q9P0M6 Q9P0M6 H2AFY2 Core histone macro-H2A.2 1 17168700.0 4991000.0 9598200.0 2579500.0 True False 4150237.638789438 9546492.591506464 3118861.5237395545 1.0 2.300227944125877 0.751489865204268 21.98476251553976 -6.684040569691741 1.8875513498881653 1.8196617795015382 0.7571860791923288 0.3427254702224659 0.550586242504928 0.4295953611035872 2.9626034099964174 0.23376435248345054 0.6133601654407508 2.069947975222492e-07 6.684040569691741 -1.0624757003092093 IHPQTIIAGWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHPQTIIAGWR 11 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 234002000.0 49581000.0 56119000.0 128302000.0 False True 65001171.14308699 47746263.95014865 115026539.7996882 1.0 0.7345446722035955 1.7696071897917105 25.953962376000362 -6.83866861197307 1.2886274113813845 0.8587531830237036 1.8027503603382626 0.9221309987757283 0.1224898608583437 0.17035939243352916 0.5501058502445493 0.07455261677768103 0.17169240884329176 1.449877759524985e-07 6.83866861197307 0.943997177314559 IHPQTIIAGWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHPQTIIAGWR 11 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 173294400.0 55219000.0 21132400.0 96943000.0 False True 53466103.07035239 29570677.524010174 71550720.0723392 1.0 0.5530733647279312 1.3382445318333844 25.672121192529183 -6.7522943517348795 1.6412129642655073 0.7379290732575909 1.340095038058918 0.6588254902521 0.18782760346624533 0.29606834252712816 1.5697009785008962 0.09037726587111844 0.21889777608052818 1.7689096381934232e-07 6.7522943517348795 0.6021659648013271 IHPQTIIAGWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHPQTIIAGWR 11 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 66112700.0 16537000.0 25894000.0 23681700.0 False True 25087838.016641308 21273013.389254577 19001001.614942178 1.0 0.8479412763723891 0.7573789978370556 24.580484813832193 -13.99999999997619 0.05403257119696612 2.0389911444205744 0.2844961793720515 0.9999679541945551 0.000566652721749546 12.52490816396137 0.05711229465944597 1.8602038543907775 0.44872433467774114 1.0000000000548252e-14 13.99999999997619 -1.7544949650485229 IHPQTIIAGWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHPQTIIAGWR 11 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 142481000.0 49581000.0 41135000.0 51765000.0 False True 67912435.57614458 39317519.68474554 39539173.13363992 1.0 0.5789443325245208 0.5822081449178468 26.017172437523254 -10.253827084134144 5.52331737179086 1.0000317176992624 0.5805762401351712 0.9999545855554552 0.0013324458300315559 5.204606477482942e-07 7.031023295949844e-08 0.0012902324730309001 0.0004300450424443611 5.574076385553988e-11 10.253827084134144 -0.4194554775640912 IHPQTIIAGWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHPQTIIAGWR 11 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 122402000.0 55219000.0 37581000.0 29602000.0 False True 45917045.1164724 37378543.693755575 35791641.33581634 1.0 0.814045058843438 0.7794848567678487 25.45252646796346 -13.999999999999998 0.2366494854424972 2.2111645074644364 0.7637103440997998 0.9995195574313743 0.00212261185336527 13.50748983799711 0.15398557921863265 7.716200630571445 0.01722637451983898 1.0000000000000041e-14 13.999999999999998 -1.4474541633646365 IHPQTIIAGWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHPQTIIAGWR 11 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 94043000.0 16537000.0 48748000.0 28758000.0 False True 21407472.493003905 46035130.94706408 23524339.081998248 1.0 2.1504234543386027 1.0988844708167276 24.351611135924642 -6.624829337725266 2.099598402946085 1.7607747431301355 1.1030521409928495 0.09904029308732087 0.49412420382213007 0.5726163295996707 4.803461490098687 0.1929580916758373 0.5474725025390244 2.3723057542491409e-07 6.624829337725266 -0.657722602137286 IHPTGK(ub)MFILSDGEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHPTGKMFILSDGEGK 16 1 P35244 P35244 RPA3 Replication protein A 14 kDa subunit 1 7969800.0 2099800.0 3575200.0 2294800.0 True False 2752858.134492123 3041794.0960204476 2057356.10927596 1.0 1.1049585366961274 0.7473527543966675 21.39249883347549 -6.828117348293542 1.3362056269138263 1.056162356336439 0.7380887798870319 0.9020651557709621 0.04696832881192731 0.18315355563113656 0.6401928563076694 0.027603143846528077 0.06353252746370186 1.4855341901312062e-07 6.828117348293542 -0.31807357644940715 IHPTGK(ub)MFILSDGEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHPTGKMFILSDGEGK 16 1 P35244 P35244 RPA3 Replication protein A 14 kDa subunit 1 8385800.0 2099800.0 3823200.0 2462800.0 True False 2876152.8049613414 3654278.3823682815 1881137.3629581449 1.0 1.2705438932398443 0.6540463913159263 21.45570889499838 -6.787426323528716 1.5066747661209594 1.1517132913723178 0.6479527027469222 0.7928637130337542 0.11483230668796525 0.23920478567003106 1.0727806324412574 0.06000100190403928 0.14074045351426046 1.6314496552229187e-07 6.787426323528716 -0.5037605886253956 IHPTGK(ub)MFILSDGEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHPTGKMFILSDGEGK 16 1 P35244 P35244 RPA3 Replication protein A 14 kDa subunit 1 8865400.0 1931900.0 4410900.0 2522600.0 True False 1606460.4476812887 4387137.606204901 3050063.9968154286 1.0 2.730934093358569 1.8986237732885294 20.615454030285065 -10.630603865314491 8.7744071944195 0.999245567510393 2.3147789333235465 0.7689015283344944 0.33978926530402426 0.005016469522317833 0.0002111891759311374 0.3291117286565526 0.10966651381187831 2.3409715444463902e-11 10.630603865314491 1.3155333658131534 IHPTSVISGYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHPTSVISGYR 11 0 P17987;E7ERF2;F5H136;F5H676 P17987 TCP1 T-complex protein 1 subunit alpha 0 26728300.0 4498100.0 12117500.0 10112700.0 False True 5897052.659662364 10309616.233645055 9066334.811868131 1.0 1.7482659268359548 1.53743494167597 22.491562646559217 -10.22843719691192 5.001492802913896 0.9999110559914627 1.6428504342564494 0.9253521511156 0.08607138927025346 8.53814782714792e-05 1.3171614308695675e-05 0.08334970565977641 0.027779421435450306 5.909664187273518e-11 10.22843719691192 0.6429393782649867 IHPTSVISGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHPTSVISGYR 11 0 P17987;E7ERF2;F5H136;F5H676 P17987 TCP1 T-complex protein 1 subunit alpha 0 12208400.0 5036700.0 1121400.0 6050300.0 False True 4876812.715450192 1569180.868023744 4465544.924890645 1.0 0.32176361069852744 0.9156687339547379 22.21750713885208 -10.523015746481661 8.948181856539781 1.0000205639501165 0.6187161723266784 0.3546482677145554 0.2424607512670778 9.947365709879432e-05 5.302527272643304e-06 0.23477423469425365 0.07825387098052758 2.99905377848224e-11 10.523015746481661 -0.3813043916234381 IHPTSVISGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHPTSVISGYR 11 0 P17987;E7ERF2;F5H136;F5H676 P17987 TCP1 T-complex protein 1 subunit alpha 0 18735900.0 4498100.0 5721200.0 8516600.0 False True 6161169.126581876 5468418.466521605 6505154.484882794 1.0 0.8875618172740214 1.0558311825618973 22.55477270808211 -6.726576155038641 1.7353399085967938 0.9320811188583452 1.0556774095042818 0.5435218124616767 0.0472802990403171 0.3426779128380164 2.019966286598075 0.02160364268148234 0.05382469107261512 1.876825281717411e-07 6.726576155038641 0.12359629064593658 IHPVSTMVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHPVSTMVK 9 0 A0A5F9ZHM4;P07195;A0A3B3IS95 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 13654400.0 5448500.0 1983800.0 6222100.0 False True 5275540.349858109 2775941.6853803354 4592345.351001117 1.0 0.5261909683725569 0.8704976261104008 22.33088743947307 -9.998185974147866 6.806758908153261 1.0000000457514637 0.698344297241479 0.5057970592871329 0.1405626044168043 9.75662337391087e-08 1.4301333881764804e-08 0.1360991767817402 0.04536638550048488 1.0041856844949225e-10 9.998185974147866 -0.3016557485099848 IHPVSTMVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHPVSTMVK 9 0 A0A5F9ZHM4;P07195;A0A3B3IS95 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 81561600.0 1649400.0 77635000.0 2277200.0 False True 2502260.3872920237 63780427.684976354 1827110.4218677848 1.0 25.4891249563361 0.7301839693210768 21.25480049468263 -8.755848676217818 2.952248400092431e-20 8.213904308038384 15.583473725053114 0.0 11.947341075218413 0.0 0.6004779943278321 4.86899243925324 4.868992368589021 1.7544917232262714e-09 8.755848676217818 7.369569417014731 IHPVSTMVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHPVSTMVK 9 0 A0A5F9ZHM4;P07195;A0A3B3IS95 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 6321700.0 1649400.0 2764500.0 1907800.0 False True 2135180.81453472 2610653.1448091916 1560599.9756810716 1.0 1.2226848082550248 0.7308982757140144 21.02592681677508 -6.783582931531835 1.5217044229875492 1.1255033587416403 0.726541604365139 0.7799228493779544 0.09432619987831892 0.24505061441785048 1.1209428998872264 0.048809455104465604 0.11483980647296611 1.645951630481327e-07 6.783582931531835 -0.3989617543765013 IHQCISINMLADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHQCISINMLADK 13 0 P60228;E5RGA2 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 6296200.0 1991800.0 1966200.0 2338200.0 False True 2728222.2863710844 1879326.7826460877 1785965.316740595 1.0 0.6888466500821141 0.654626027234818 21.379529764412226 -13.999999999999998 0.31169905734853515 4.037793506317626 0.6471847519494304 0.9996757236536918 0.0027979244123597694 17.39157252637293 0.177704095953167 34.297576454626395 0.011776755757674241 1.0000000000000041e-14 13.999999999999998 -3.3906087543681953 IHQESELHSYLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHQESELHSYLSR 13 0 Q9UNE7;Q9UNE7-2;H3BTA3;H3BS86;H3BUD0 Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP 0 5326100.0 1747900.0 1720900.0 1857300.0 False True 2291513.8266876754 1464148.4280156607 1665124.4124796249 1.0 0.6389437458171701 0.7266482065641818 21.127869560091412 -10.03507574788106 5.899634021555914 1.0000006436336146 0.68279597619064 0.9457731656484762 0.035805196166150216 3.0313605289178675e-07 4.956155565461468e-08 0.03466830236930564 0.011556077371580459 9.224105300223819e-11 10.03507574788106 -0.3172046674429746 IHQETFGK(ub)SGCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHQETFGKSGCR 12 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 112344000.0 30213000.0 55583000.0 26548000.0 True False 39609535.58310822 47290233.06083705 23801067.626398057 1.0 1.1939103138842235 0.6008923678607381 25.239344450132823 -6.818639549934364 1.3778587021787694 1.1046606184293113 0.5883306321102982 0.8812061282640329 0.08509169922289386 0.19525259990114885 0.7287607479344376 0.048535795087441366 0.11190391776935257 1.5183099917735975e-07 6.818639549934364 -0.5163299863190131 IHQETFGK(ub)SGCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHQETFGKSGCR 12 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 73185000.0 36748000.0 26650000.0 9787000.0 True False 35581454.854838185 37291483.97791407 7223491.096293532 1.0 1.0480595616467145 0.2030128089411532 25.084622164950098 -6.893423065406298 1.00189624978404 1.0417498693675655 0.125258140566448 0.9830008962983423 0.05052615129216654 0.1164103793309502 0.20596784791746403 0.0382417339312098 0.09659204489266573 1.278135609252792e-07 6.893423065406298 -0.9164917288011175 down IHQETFGK(ub)SGCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHQETFGKSGCR 12 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 166919000.0 59597000.0 65497000.0 41825000.0 True False 90413006.12431355 53808548.619603306 33558270.4174513 1.0 0.5951416828859681 0.3711664046576472 26.430026986867155 -9.698573213434411 0.14340879929811376 1.6501568463049636 2.477292067306823e-10 0.999799485160718 0.0036850278561579705 1.1751499870882491 0.060432659787393435 0.4974540377841217 0.19841898244836922 2.0018281246312818e-10 9.698573213434411 -1.6501568460572344 IHQETFGK(ub)SGCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHQETFGKSGCR 12 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 104049000.0 30213000.0 45204000.0 28632000.0 True False 41383562.57562488 43206737.81036199 21869711.294549953 1.0 1.0440555409265553 0.5284637168340678 25.302554511655714 -6.886118737432513 1.0450484743946349 1.0303353827304664 0.4873454590217793 0.9782963475500249 0.034379327544967385 0.12234967374646472 0.24068501321038172 0.025184598488956798 0.06197061525286529 1.2998141563043347e-07 6.886118737432513 -0.5429899237086871 IHQETFGK(ub)SGCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHQETFGKSGCR 12 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 71018000.0 36748000.0 19562000.0 14708000.0 True False 30557590.212429196 19456615.623247035 17783374.797891606 1.0 0.6367195674786267 0.5819626048476256 24.865027440384374 -13.999999999999998 0.2664321495152863 3.750989777272869 0.5631489146440747 0.99957571496873 0.0038211678931903384 14.711259145845235 0.1633721196108654 21.87390126078258 0.023154676626250578 1.0000000000000041e-14 13.999999999999998 -3.187840862628794 IHQETFGK(ub)SGCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHQETFGKSGCR 12 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 129000000.0 59597000.0 47751000.0 21652000.0 True False 77149491.33250013 45093614.87349752 17711558.168281045 1.0 0.5844965934921377 0.22957452942816542 26.201153308959604 -7.786609768638274 0.3087012357465548 1.1007737655997971 1.4075038377808912e-14 0.9993375937644535 0.008103342597486398 0.11907508157125175 0.04846044239194145 0.039947898958149715 0.08168080269035685 1.634519971328798e-08 7.786609768638274 -1.1007737655997831 down IHQETFGK(ub)SGCRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHQETFGKSGCRR 13 2 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 7952300.0 1185000.0 3597300.0 3170000.0 True False 1797731.6351043107 2955333.7091668127 2543448.110539645 1.0 1.643923737813811 1.414809675078152 20.777746241121505 -10.211475997264207 4.9752776433626025 0.9999368149446689 1.5293667064465792 0.8768145887291825 0.09353542443521096 6.556583554232851e-05 1.039122550341909e-05 0.09057604770557331 0.030188428426194115 6.145029933286179e-11 10.211475997264207 0.5294298915019103 IHQTGLK(ub)VVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHQTGLKVVR 10 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 1 1496640.0 639160.0 421530.0 435950.0 True False 875474.7246495348 402905.41078669735 332987.58867208136 1.0 0.46021364117391994 0.3803508876916819 19.739706002439856 -13.999999999999998 0.2690862995445786 5.145903908915279 0.35360592549721875 0.9995813674159267 0.005631130946400273 14.838430776888753 0.1642030933256724 33.63498086495544 0.033320840423799854 1.0000000000000041e-14 13.999999999999998 -4.79229798341806 IHTGEKPYK(ub)CEECGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHTGEKPYKCEECGK 15 2 Q8TF20-2;M0R1M8;K7EP55;A0A075B7G4;P0DPD5;B9EG95;A0A087WYK5;A0A0B4J2G0;A0A087WV98;A0A075B7G2;A0A1W2PNY2;A0A075B7G3;B1APK8;A0A1W2PRC0;Q02386;Q03938;P35789;Q8IYB9;Q86V71;O43345-2;Q8NB50-2;Q9UII5;Q2VY69;Q8NB50-3;Q8NB50;Q8TF20;Q8TAQ5;Q8NEM1;P35789-2;O95780;O95780-2;O75346-2;B4DX44;Q3SXZ3-2;O95780-3;Q3SXZ3;Q03924;A8MUV8;Q14593;O75346;Q6ZMV8;Q14593-2;Q8IW36;Q5SXM1;P35789-3;Q8TAQ5-2;O43345;Q15929;P17038-2;P0DKX0;P17038;A0A087WZJ7;Q6ZR52-2;A0A087X1I5;A0A3B3ITU2;Q49A12;A0A087WU35;O75437;A0A0G2JMG9;A0A075B7G6;A0A0A0MR41;A0A0G2JP77;C9IZS8;A0A087WUU8;A0A0A0MTN5;A0A0G2JQ90;A0A087WSW2;Q6ZR52;A0A087X0A2;F5H2M4;Q8N7Q3;Q03923;Q03936;A6NNF4-3;Q96N22;Q05481-2;Q6ZN08;A6NK75;Q03936-2;Q05481;A6NNF4;Q8TD23;Q96N22-2;Q9Y2Q1-3;Q5JVG8-2;Q5JVG8;Q68DY1-2;Q96H40;Q15928;P17019;Q96N38-2;Q96N38-3;Q68DY1;Q9Y2Q1-4;Q9P255;Q8TF32;Q9Y2Q1-2;O75373;Q8IYN0;Q03936-3;Q96N38;Q03923-2;Q9Y2Q1;A8MTY0 Q8TF20-2;Q15929;P17038-2 ZNF721;ZNF737;ZNF253;ZNF595;ZNF682;ZNF107;ZNF429;ZNF208;ZNF678;ZNF45;ZNF90;ZNF93;ZFP62;ZNF284;ZNF420;ZNF680;ZNF736;ZNF718;ZNF117;ZNF727;ZNF273;ZNF730;ZNF695;ZNF56;ZNF43;ZNF728;ZNF254;ZNF493;ZNF626;ZNF85;ZNF714;ZNF100;ZNF726;ZNF92;ZNF708;ZNF676;ZNF681;ZNF91;ZNF66;ZNF98;ZNF675;ZNF257;ZNF506;ZNF486;ZNF141;ZNF492;ZNF431;ZNF724P Zinc finger protein 721;Zinc finger protein 45;Zinc finger protein 90;Zinc finger protein 93;Zinc finger protein 595;Zinc finger protein 429;Zinc finger protein 208;Zinc finger protein 62 homolog;Zinc finger protein 107;Zinc finger protein 284;Zinc finger protein 420;Zinc finger protein 680;Zinc finger protein 682;Zinc finger protein 253;Zinc finger protein 736;Zinc finger protein 718;Zinc finger protein 117;Putative zinc finger protein 727;Zinc finger protein 273;Putative zinc finger protein 730;Zinc finger protein 695;Zinc finger protein 678;Putative zinc finger protein 56;Zinc finger protein 43;Zinc finger protein 728;Zinc finger protein 493;Zinc finger protein 254;Zinc finger protein 676;Zinc finger protein 85;Zinc finger protein 92;Zinc finger protein 726;Zinc finger protein 681;Zinc finger protein 91;Putative zinc finger protein 66;Zinc finger protein 98;Zinc finger protein 675;Zinc finger protein 257;Zinc finger protein 506;Zinc finger protein 626;Zinc finger protein 486;Zinc finger protein 141;Zinc finger protein 708;Zinc finger protein 714;Zinc finger protein 492;Zinc finger protein 431;Zinc finger protein 737;Zinc finger protein 100;Putative zinc finger protein 724 1 11341900.0 1641300.0 1385200.0 8315400.0 True False 2124695.2048598486 1308112.4023113386 6802082.52320913 1.0 0.615670614457675 3.20143920297397 21.018824465644705 -6.869089616341308 1.138972584768867 0.783811188141078 3.350230985607436 0.9637623816006671 0.21686252233800402 0.13772695115996253 0.33450719729842876 0.14785322375845547 0.34948780599372264 1.351793592816427e-07 6.869089616341308 2.566419797466358 up IHVCLYFIAPTGHSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHVCLYFIAPTGHSLK 16 0 Q14141;B1AMS2;Q14141-2;Q14141-4;Q14141-3 Q14141 SEPT6 Septin-6 0 211490000.0 42586000.0 77891000.0 91013000.0 False True 64606075.45363045 63990742.48483923 73024240.65758505 1.0 0.9904756175874998 1.1302999005100776 25.945166504280678 -6.890584485433498 1.0188848206798762 0.9925920380479678 1.1424662445681357 0.981270936990974 0.008729583493581062 0.11867153928153054 0.21907138499798373 0.006522967882270582 0.016296987577337992 1.2865169562376246e-07 6.890584485433498 0.14987420652016792 IHVCLYFIAPTGHSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHVCLYFIAPTGHSLK 16 0 Q14141;B1AMS2;Q14141-2;Q14141-4;Q14141-3 Q14141 SEPT6 Septin-6 0 185815000.0 42586000.0 77147000.0 66082000.0 False True 55128416.49555931 72853701.63233678 54055754.05857878 1.0 1.321527195293289 0.9805424769081308 25.716292826373127 -6.659471172765133 1.975232982369073 1.2070579616286814 0.9819786463392791 0.23320590956769638 0.13691719653846557 0.48567210591408255 3.642211092911814 0.05601966556762119 0.15172638867422672 2.1904272175838177e-07 6.659471172765133 -0.22507931528940228 IHVFYIDYGNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHVFYIDYGNR 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 472290000.0 167222000.0 143424000.0 161644000.0 False True 219229661.3801516 122025698.26237313 144918629.4787361 1.0 0.5566112609679056 0.6610356854378493 27.707867764655813 -9.837374465728448 6.377484312640334 1.0000000150572852 0.6088234732028044 0.9492650351365917 0.04263109277283311 9.128636104825024e-09 1.6395767921357239e-09 0.04127737931497606 0.01375912602827213 1.4542046675823844e-10 9.837374465728448 -0.3911765418544808 IHVFYIDYGNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHVFYIDYGNR 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 321129000.0 112534000.0 53029000.0 155566000.0 False True 108961669.76799734 74203756.24258173 114818597.72003661 1.0 0.6810078847045696 1.0537521861082886 26.699245476111 -6.680078816010644 1.9012281880704287 0.7981920718446456 1.0523483889347198 0.3246933009534928 0.13519271190638632 0.43832411444338565 3.063240517458717 0.057051546072366545 0.15047535951258983 2.0889169986024198e-07 6.680078816010644 0.25415631709007425 IHVFYIDYGNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHVFYIDYGNR 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 444297000.0 135448000.0 132272000.0 176577000.0 False True 205484518.57519722 108667028.15414694 141676478.55355164 1.0 0.5288331642093035 0.6894751951919191 27.614454462902994 -10.326259425057387 6.380422184446475 1.0000196451867236 0.6091541797006114 0.8875495257059784 0.06558183452529598 1.8327928593503837e-05 1.935207171156182e-06 0.06350252456986516 0.021166446077516794 4.71781139427783e-11 10.326259425057387 -0.39086546548611223 IHVFYIDYGNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHVFYIDYGNR 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 457791000.0 167222000.0 121551000.0 169018000.0 False True 229048492.40463185 116180474.90459494 129099429.43497637 1.0 0.507230908550811 0.5636336134747931 27.771077826178704 -10.10857480986104 4.9102638414660476 1.000018604580638 0.535432261013398 0.9890657693328759 0.023026307876888565 4.914328929686224e-06 8.921918644287607e-07 0.02229606117266638 0.0074317089089240345 7.787986502032336e-11 10.10857480986104 -0.46458634356724005 IHVFYIDYGNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHVFYIDYGNR 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 235076000.0 112534000.0 59394000.0 63148000.0 False True 93577007.10148884 59074032.733214006 76351954.83663699 1.0 0.6312879046147023 0.815926446053458 26.479650751545275 -10.135280994393735 5.158137077786825 1.0000095760750338 0.7236071753337667 0.749233444661985 0.07537836889720556 8.301251901170698e-06 1.3916615526293821e-06 0.07298731952057393 0.024328263950105986 7.323505391279961e-11 10.135280994393735 -0.2764024007412671 IHVFYIDYGNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHVFYIDYGNR 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 570505000.0 135448000.0 278360000.0 156697000.0 False True 175340106.0792403 262869021.30189443 128179753.84699492 1.0 1.4991950625551564 0.7310349965744146 27.385580784995444 -6.731313437363075 1.7185741710267883 1.2999703966407874 0.7313899146878011 0.5653286655476979 0.20982790989472994 0.3337594996734339 1.9318080132044568 0.09673443402887334 0.2396716382692736 1.8564641312452868e-07 6.731313437363075 -0.5685804819529863 IHVIDHSGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHVIDHSGAR 10 0 Q99426;K7EP07;A0A494C0X0;Q99426-2;K7EK42 Q99426 TBCB Tubulin-folding cofactor B 0 2287280.0 665060.0 414020.0 1208200.0 False True 643948.034335439 579340.345085777 891736.1747769321 1.0 0.8996694052861924 1.384795243139787 19.29658474409427 -6.852773961115774 1.2216502891735643 0.9463057520512296 1.4052493815050173 0.9442427467910455 0.049373184304234194 0.15443221637397564 0.4421296524011838 0.031601008758529184 0.07326728401801004 1.4035440223318583e-07 6.852773961115774 0.45894362945378775 IHVILAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHVILAQK 8 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 18144800.0 6309500.0 5839700.0 5995600.0 False True 8271815.60128492 4968439.522972314 5375232.825856265 1.0 0.6006467941815011 0.6498250305557212 22.979772594184347 -10.405184245601419 5.357728442804794 1.0002437230934025 0.6252359123686054 0.9872497616782164 0.02007693092782299 5.848640299657658e-05 6.493134491383925e-06 0.01945186948590169 0.006479801593865041 3.933831507199128e-11 10.405184245601419 -0.37500781072479705 IHVILAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHVILAQK 8 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 7279400.0 2430200.0 1328500.0 3520700.0 False True 2353054.6312242276 1858976.97803598 2598523.0512639866 1.0 0.7900271219239848 1.1043190484328231 21.166103385543554 -6.726640907968927 1.7353125657213364 0.8731685485337354 1.1040254190943262 0.54366411737308 0.08829361666468277 0.3425891266689375 2.0194514048922825 0.04034544380018994 0.10050379540685166 1.876545469557376e-07 6.726640907968927 0.2308568705605908 IHVILAQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHVILAQK 8 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 16918700.0 5043200.0 5824000.0 6051500.0 False True 7650903.107306377 4784661.696880301 4855418.372533324 1.0 0.6253721462386704 0.6346202931123973 22.867198621904897 -10.602194332714939 6.434421396777302 1.0010198982907017 0.6299962196755339 0.9995316657166834 0.0037755401511577187 5.537878706498463e-05 3.423765530391669e-06 0.003664889244661418 0.0012185503440309395 2.4992267884083316e-11 10.602194332714939 -0.37102367861516783 IHVILAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHVILAQK 8 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 14675700.0 6309500.0 3386200.0 4980000.0 False True 8642292.657826275 3236586.4873340363 3803826.566319461 1.0 0.37450554100398964 0.4401409113211177 23.042982655707238 -10.192390034584992 5.381667850613131 1.000026701110336 0.40732322616753763 0.9908856669672983 0.026795527726314737 8.58477850370446e-06 1.2883058635261604e-06 0.0259458239874972 0.00864821938634905 6.421107864113786e-11 10.192390034584992 -0.5927034749427984 IHVILAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHVILAQK 8 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 6841600.0 2430200.0 2622900.0 1788500.0 False True 2020818.9761142258 2608769.917095113 2162467.080910328 1.0 1.2909468625989653 1.0700944055209107 20.94650866097783 -10.237627757829765 4.3829120652895135 0.9999177537924473 1.1805206340633354 0.47112778391549026 0.09016263805834954 7.249444745887251e-05 1.2609611704678651e-05 0.08733931178088664 0.02909986630257128 5.785917570799227e-11 10.237627757829765 0.1806028802708881 IHVILAQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHVILAQK 8 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 18486400.0 5043200.0 7780300.0 5662900.0 False True 6528521.816334123 7347319.465566631 4632310.306260791 1.0 1.1254185361200613 0.7095496402678658 22.638324943997347 -6.825838162791399 1.3464897056091052 1.067230515091353 0.6992873186089383 0.89727456264998 0.05582508799688515 0.1860036876113599 0.6609945535174245 0.032566369233665134 0.07496709086657086 1.4933507940355977e-07 6.825838162791399 -0.3679431964824147 IHVLEAQDLIAK(ub)DR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHVLEAQDLIAKDR 14 1 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 16955800.0 4564200.0 5973700.0 6417900.0 True False 4419311.969316767 8359029.562433967 4736859.457127032 1.0 1.8914775920936597 1.071854508125924 22.075390347149092 -10.419664918044088 4.294106001680016 0.9984507219575012 1.48166605011104 0.3152894634416632 0.33460972286482094 0.004984591098283498 0.0006736516714419878 0.3249503306675513 0.10799482367642285 3.8048284643435137e-11 10.419664918044088 0.48321532815353874 IHVLEAQDLIAK(ub)DR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHVLEAQDLIAKDR 14 1 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 45556400.0 6036300.0 9887100.0 29633000.0 True False 9157508.412641468 8122669.756735117 23776024.56139471 1.0 0.8869956095833 2.5963420932896044 23.126523690605598 -6.891094699844569 1.0158521161528717 0.9105509644882679 2.746572125737883 0.9815908778608536 0.10590151387615455 0.11826070845975246 0.21667988574238412 0.07931394846087708 0.19853255860555133 1.2850064280213776e-07 6.891094699844569 1.836021161249615 up IHVLEAQDLIAK(ub)DR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHVLEAQDLIAKDR 14 1 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 11215100.0 2704300.0 3871700.0 4639100.0 True False 3704152.7909595957 3700635.4920002325 3543440.12526357 1.0 0.9990504444179658 0.9566128411095073 21.82071217823912 -6.911725730333509 0.8839095479099204 1.0012433234897042 0.9509212940692734 0.9915563956612201 0.0018591650436257105 0.10328766535283201 0.13266223560094317 0.0015352317977708526 0.004290309770192847 1.2253898244671837e-07 6.911725730333509 -0.05032202942043085 IHVLEAQDLIAK(ub)DR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHVLEAQDLIAKDR 14 1 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 13568500.0 4564200.0 5536200.0 3468100.0 True False 3795334.528343568 5506375.391750339 4193263.675317366 1.0 1.4508274173537836 1.104846922979269 21.85579562258337 -10.0173709122279 5.213664877901404 0.9999979073772708 1.2778371701675122 0.4623185122975969 0.14124594536567983 3.43568037393595e-06 6.476907350943814e-07 0.1367618296222126 0.045586932842887805 9.607913573245519e-11 10.0173709122279 0.2778392627902414 IHVLEAQDLIAK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHVLEAQDLIAKDR 14 1 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 32398700.0 6036300.0 7817400.0 18545000.0 True False 7814109.343261746 7382354.817953123 15170000.287768876 1.0 0.9447468026946753 1.9413601245355305 22.897650012698048 -6.893783299500307 0.9997510034043391 0.9512056687489729 2.0337056451941455 0.9832108211425513 0.059259118367348325 0.11612651278620412 0.20435463088984304 0.0449248968399427 0.11363472023665865 1.2770758741199548e-07 6.893783299500307 1.0824999764451726 IHVNLTVFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHVNLTVFEK 10 0 C9K0I8;Q9HB29 C9K0I8 IL1RL2 Interleukin-1 receptor-like 2 0 26635500.0 9821400.0 5408100.0 11406000.0 False True 9509625.03296255 7567582.532868928 8418426.427334636 1.0 0.7957813800899557 0.885253245859267 23.180957025683362 -10.107569910213092 4.589292214098397 1.0000127959722316 0.8405173129705477 0.8090276335410844 0.03652673625878257 4.782826747316636e-06 9.30075829457702e-07 0.035369697239537375 0.011788953433179032 7.80602773105354e-11 10.107569910213092 -0.15949548300168392 IHVNLTVFEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHVNLTVFEK 10 0 C9K0I8;Q9HB29 C9K0I8 IL1RL2 Interleukin-1 receptor-like 2 0 41844500.0 5659600.0 9635900.0 26549000.0 False True 7752107.064939145 9210154.076339865 20278672.993818324 1.0 1.1880839621004597 2.6158917600008036 22.88615706538549 -6.931085639434406 0.7378303478146834 0.9791386411775524 2.9172813094209014 0.9967472982646431 0.04114916963757097 0.09207796036428158 0.07494817175307962 0.037733936257446546 0.1284293157308663 1.1719642406886735e-07 6.931085639434406 1.938142668243349 up IHVNLTVFEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHVNLTVFEK 10 0 C9K0I8;Q9HB29 C9K0I8 IL1RL2 Interleukin-1 receptor-like 2 0 17933400.0 6175900.0 6976100.0 4781400.0 False True 7994824.2951891525 6587873.902515245 3911234.2613069955 1.0 0.8240173466325541 0.4892207904632203 22.9306348968078 -6.961011022719682 0.4209427515570916 1.0146492801994755 0.28593993740941087 0.9998058768242175 0.002951770449473467 0.07934191678825443 0.019811356516353948 0.004333538483806493 0.027862037767663293 1.0939286011913746e-07 6.961011022719682 -0.7287093427900646 down IHVSDQELQSANASVDDSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IHVSDQELQSANASVDDSR 19 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 34634100.0 2871100.0 12832000.0 18931000.0 False True 3764039.903771952 10917515.618744234 16972201.718974754 1.0 2.9004781824453483 4.509038733082207 21.84385049193599 -7.36694537111406 0.20992761761971537 1.6880671807063661e-18 6.819763319895084 0.9999628564359422 0.008740868413677908 0.1205999635846537 0.015832404095897045 0.13470729715826052 0.323223665578713 4.295904605445331e-08 7.36694537111406 6.819763319895084 IHVSDQELQSANASVDDSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHVSDQELQSANASVDDSR 19 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 17897800.0 5636300.0 2309300.0 9952200.0 False True 5457378.741654636 3231415.5328404107 7345420.260399757 1.0 0.59211861331447 1.3459612403907815 22.379776739431307 -6.759710557944699 1.613226082976259 0.7630068201932476 1.3487128987004686 0.6899761048657703 0.17154989521033548 0.2833706995615731 1.4533659898669824 0.08390034593305541 0.2017102576660962 1.738959398142429e-07 6.759710557944699 0.585706078507221 IHVSDQELQSANASVDDSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHVSDQELQSANASVDDSR 19 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 24656100.0 2871100.0 10026000.0 11759000.0 False True 3932623.2585601094 9583018.168451661 8981766.384206926 1.0 2.43680046075921 2.2839122371196856 21.90706055345888 -10.136567944404725 4.565866678219031 0.9998446428531426 2.3603563489680814 0.9906155440390348 0.062416356030468544 21802241.04970994 11.057394504496424 35610.45420430168 0.021366778832400138 7.301835683434547e-11 10.136567944404725 1.3605117061149388 IHVSDQELQSANASVDDSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHVSDQELQSANASVDDSR 19 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 9587900.0 5636300.0 2001300.0 1950300.0 False True 4686833.180426548 1990518.5996730542 2358098.7128316523 1.0 0.4247043841854634 0.5031326317906288 22.160182014865583 -10.645845453915662 6.624610746303561 1.0024159881602819 0.46391850798836604 0.9842010402564356 0.03201819800888534 0.0011460831670765557 6.127001107146775e-05 0.031098880811336934 0.01033382897199871 2.2602399459659494e-11 10.645845453915662 -0.5384974801719158 IHVVDSGLTFNLPYPLILRPQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHVVDSGLTFNLPYPLILRPQR 22 1 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 0 37150200.0 26828000.0 1452500.0 8869700.0 False True 25976359.824904714 2032490.8246874372 6546459.484703659 1.0 0.07824386628409713 0.2520160456981071 24.630695938318755 -10.452021958426291 9.894084534269249 1.0000031613869107 0.16512995599113683 0.9685299761417467 0.07094219517594925 4.947298228758092e-06 2.739403595450135e-07 0.06868974474024832 0.02289649503832064 3.531653128979182e-11 10.452021958426291 -0.8348732053957739 IHVVDSGLTFNLPYPLILRPQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IHVVDSGLTFNLPYPLILRPQR 22 1 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 0 263375000.0 98348000.0 66969000.0 98058000.0 False True 149201106.20188922 55017858.71881472 78676793.3196519 1.0 0.3687496702897641 0.5273204423376834 27.152682991113387 -10.420097513581329 9.086258915580249 1.000002970074608 0.4480350563145598 0.9417090288319832 0.06473624660609797 3.894986182262653e-06 2.48558790524306e-07 0.06268093818720477 0.020893533750116156 3.8010404071660576e-11 10.420097513581329 -0.5519679137600482 IHVVDSGLTFNLPYPLILRPQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IHVVDSGLTFNLPYPLILRPQR 22 1 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 0 54635530.0 26828000.0 13513800.0 14293730.0 False True 22308670.68191603 13440998.477120716 17282482.85625967 1.0 0.6025010933536407 0.7746980132827586 24.41110121375303 -10.213743293344445 5.448918341897589 1.0000161834325043 0.6885995533181684 0.8134467951271137 0.07029909818431518 1.3821546479799267e-05 1.994350274989158e-06 0.06807034419167608 0.022688936376755106 6.113032527146104e-11 10.213743293344445 -0.31141663011433596 IHVVDSGLTFNLPYPLILRPQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IHVVDSGLTFNLPYPLILRPQR 22 1 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 0 173316600.0 98348000.0 40678000.0 34290600.0 False True 127313424.72890793 38414233.541164204 28050062.65126814 1.0 0.30172963788352025 0.22032289769123664 26.923809313205837 -13.999999999999998 0.30327948833157825 7.490967860058324 0.20096514325669448 0.9996571349854073 0.006479651279867451 16.805197942892807 0.17499570829678818 68.57819437932183 0.02901108219010298 1.0000000000000041e-14 13.999999999999998 -7.290002716801629 IHVYGYSMAYGPAQHAISTEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IHVYGYSMAYGPAQHAISTEK 21 0 Q9NRX4 Q9NRX4 PHPT1 14 kDa phosphohistidine phosphatase 0 20964500.0 6088300.0 4402200.0 10474000.0 False True 5895030.249066936 6160021.417169725 7730545.186735295 1.0 1.0449516214348062 1.3113665002751909 22.49106778542436 -6.936095031958962 0.6949370534445686 0.9967140651854467 1.375645945505774 0.9976064727748243 0.006722859797086798 0.08959392778967427 0.0630645957628878 0.006364685145495074 0.02335131259904333 1.1585238211936136e-07 6.936095031958962 0.3789318803203272 IHVYGYSMAYGPAQHAISTEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IHVYGYSMAYGPAQHAISTEK 21 0 Q9NRX4 Q9NRX4 PHPT1 14 kDa phosphohistidine phosphatase 0 28357500.0 9728900.0 8474600.0 10154000.0 False True 13325937.243636735 8100164.150245418 7755834.328194328 1.0 0.6078494894693673 0.5820104197097141 23.66773366880541 -13.999999999999998 0.38651318962878956 7.063984239083648 0.5799945549399008 0.9998178055915639 0.0025813802720632733 24.88007034096333 0.2034185654428482 125.87135115813112 0.006869911191351003 1.0000000000000041e-14 13.999999999999998 -6.483989684143747 IIAATFLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIAATFLFK 9 0 Q13907;Q13907-2 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 0 7427510.0 2589800.0 4297100.0 540610.0 False True 3395252.8796588755 3655989.4299646122 484672.8630972972 1.0 1.0767944419892321 0.14275015154276013 21.69508760024284 -6.886963903295465 1.0402137476720499 1.053900984822114 0.06704537437860354 0.9788813547546279 0.06152585883176877 0.12163949658158821 0.2365335229503224 0.045238355574205566 0.11161120447001419 1.2972870914716211e-07 6.886963903295465 -0.9868556104435103 down IIAATFLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIAATFLFK 9 0 Q13907;Q13907-2 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 0 13996000.0 7336900.0 4965500.0 1693600.0 False True 7103994.125516015 6948250.044740426 1249995.3530890706 1.0 0.9780765470770606 0.17595669858444235 22.76019895800932 -6.912757140247172 0.8767558018963982 1.0227224267456347 0.06594468296810946 0.9919209185791311 0.034460948019924144 0.10262287735758212 0.129089092347876 0.028604011202123702 0.08055229454071815 1.222483088015479e-07 6.912757140247172 -0.9567777437775253 down IIAATFLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIAATFLFK 9 0 Q13907;Q13907-2 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 0 82737000.0 24034000.0 28269000.0 30434000.0 False True 36461335.12075699 23224176.08329486 24418706.56030392 1.0 0.6369535291666713 0.6697150962637857 25.119864054355148 -9.958828014370253 5.849371687672501 1.0000002816493252 0.6533343131371945 0.9933462021936935 0.013374853760807196 4.913046594217447e-08 8.742429826572503e-09 0.01295015698497515 0.004316715489391805 1.0994411446226996e-10 9.958828014370253 -0.3466659685121307 IIAATFLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIAATFLFK 9 0 Q13907;Q13907-2 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 0 16060700.0 2589800.0 5258900.0 8212000.0 False True 3547319.0467134435 5026544.4091432765 6272494.731448865 1.0 1.4169981168737333 1.7682352923006093 21.75829766176573 -6.973108412325781 0.168093689156042 0.6815922544537278 2.513030368624053 0.9999975864534437 0.000487804473122798 0.07530637559604218 0.005232608978266359 0.015064673896692797 0.04095658342704523 1.0638774108398795e-07 6.973108412325781 1.8314381141703253 IIAATFLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIAATFLFK 9 0 Q13907;Q13907-2 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 0 14841400.0 7336900.0 3577900.0 3926600.0 False True 6100957.42978045 3558625.1425424507 4747633.905452894 1.0 0.583289620276946 0.7781785006855463 22.540604233443595 -10.100163189873015 4.821367701273922 1.0000132346558024 0.6807340604803386 0.781575580017897 0.07956305227115706 1.2525936980232561e-05 2.337813140537554e-06 0.07704012603267772 0.02567886469961897 7.940298151539053e-11 10.100163189873015 -0.3192791741754638 IIAATFLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIAATFLFK 9 0 Q13907;Q13907-2 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 0 73710000.0 24034000.0 29450000.0 20226000.0 False True 31112486.78096734 27811081.61136945 16545075.536285464 1.0 0.8938880973147578 0.5317824850441302 24.890990376447597 -6.948524441644109 0.5748147324851561 1.004417811175653 0.40350126712525625 0.9990803434006736 0.006078694554713981 0.08408371899328272 0.03845662537317958 0.006405193798849797 0.030207128395100133 1.1258371061644485e-07 6.948524441644109 -0.6009165440503967 IIAFVGSPVEDNEK(ub)DLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIAFVGSPVEDNEKDLVK 18 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 200485600.0 63834000.0 88707600.0 47944000.0 True False 83686992.16933534 75472771.85951652 42983214.791322395 1.0 0.9018459130040442 0.5136188274558677 26.3185000600913 -6.9451330104139295 0.6099427394756222 1.0042945770082916 0.39095450225769907 0.9987618543333726 0.007389526293259832 0.08550096992681996 0.04451847503212833 0.007511690353455615 0.03273564630762626 1.1346632516375441e-07 6.9451330104139295 -0.6133400747505926 IIAFVGSPVEDNEK(ub)DLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIAFVGSPVEDNEKDLVK 18 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 327358200.0 122616300.0 112862900.0 91879000.0 True False 118723912.67326918 157929644.54224822 67813133.58908278 1.0 1.33022607650132 0.5711834462169892 26.823035302508746 -6.788430651737865 1.5023684500843602 1.1849355587993562 0.5634282876511738 0.7962980803488952 0.14025095822791622 0.2376818602007295 1.059812809393001 0.07348365374966088 0.1722588689159658 1.62768120347376e-07 6.788430651737865 -0.6215072711481824 IIAFVGSPVEDNEK(ub)DLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIAFVGSPVEDNEKDLVK 18 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 605130000.0 254570000.0 222800000.0 127760000.0 True False 386201301.559919 183039599.25565442 102508180.00080271 1.0 0.47394868561118997 0.2654268113203099 28.524777785507805 -12.937643931501004 0.14117986532149496 2.876536259923794 1.522210735977711e-17 0.9996203085797434 0.006022751758282223 8.095769823347421 0.10784529989807186 4.453777742053225 0.22303698948947137 1.154399336573414e-13 12.937643931501004 -2.876536259923794 IIAFVGSPVEDNEK(ub)DLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIAFVGSPVEDNEKDLVK 18 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 266290200.0 63834000.0 88476200.0 113980000.0 True False 87435154.84898677 84567028.93233223 87060271.4917855 1.0 0.9671971082843256 0.9957124413189551 26.38171012161419 -10.358090023149618 5.370912366753498 1.000006615910175 0.981454774801641 0.3605962125048051 0.011641335963396844 9.225627227361753e-07 1.1026675336925366e-07 0.011275696132708738 0.0037572250261532136 4.3843980593791044e-11 10.358090023149618 -0.01855184110853403 IIAFVGSPVEDNEK(ub)DLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIAFVGSPVEDNEKDLVK 18 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 298789500.0 122616300.0 121660200.0 54513000.0 True False 101960886.27311099 121004792.35494117 65911416.26036604 1.0 1.1867765844131588 0.6464382438165225 26.603440577943022 -6.81336598215055 1.4003670552228091 1.101393160047134 0.6362417662215106 0.8684329487833169 0.0812742159625053 0.20224239836755023 0.7810098678537417 0.045627529816230285 0.10539273406137852 1.5368589756372058e-07 6.81336598215055 -0.4651513938256234 IIAFVGSPVEDNEK(ub)DLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIAFVGSPVEDNEKDLVK 18 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 677466100.0 254570000.0 265546100.0 157350000.0 True False 329545883.3249082 250768226.101218 128713914.54734088 1.0 0.7609508684227101 0.3905796462959859 28.295904107600254 -6.964713690366118 0.3629333478524421 1.0308642771717051 0.10791598857733121 0.9999071198844487 0.0024162216168985527 0.0780582544460621 0.015203392693679152 0.0049407045072181474 0.03157974700501787 1.0846417309232911e-07 6.964713690366118 -0.922948288594374 down IIAFVGSPVEDNEKDLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIAFVGSPVEDNEKDLVK 18 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 0 8185400.0 1919300.0 3524700.0 2741400.0 False True 2516220.88652764 2998828.499172989 2457746.2253656588 1.0 1.191798587806551 0.9767609189339989 21.262827144128938 -6.671480154767576 1.9321235918071498 1.1222678362497365 0.9776241348397744 0.2856319905600141 0.08144409915585105 0.4577210283804245 3.2956521689463796 0.03391819005200577 0.09044643472615888 2.130687927819762e-07 6.671480154767576 -0.14464370140996208 IIAFVGSPVEDNEKDLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIAFVGSPVEDNEKDLVK 18 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 0 7311000.0 3249100.0 1774300.0 2287600.0 False True 3145959.098967419 2482787.2428522687 1688408.9334710427 1.0 0.7891988308643875 0.536691317450764 21.585068483529632 -6.968725429163036 0.2869997504069753 1.0511426783261337 0.26697850433481796 0.9999706633195229 0.0010258389128718207 0.0767184735256764 0.010503153639105053 0.004483942729775001 0.022979193777347764 1.074668627529659e-07 6.968725429163036 -0.7841641739913158 IIAFVGSPVEDNEKDLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIAFVGSPVEDNEKDLVK 18 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 0 11457900.0 1919300.0 4606200.0 4932400.0 False True 2628917.0771322553 4402682.85333354 3767468.7059666812 1.0 1.6747134748488115 1.4330876917869204 21.32603720565183 -10.320038996773254 5.319286357308176 0.9998661789187637 1.5539005833178954 0.8751051807531124 0.09864331286711242 0.0001565854536621528 2.001609210779033e-05 0.09553379249296794 0.031836992329072944 4.785871164341854e-11 10.320038996773254 0.5540344043991317 IIAFVGSPVEDNEKDLVK(ub)LAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIAFVGSPVEDNEKDLVKLAK 21 2 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 86775000.0 0.0 29647000.0 57128000.0 True False 0.0 28337097.510481395 43635542.98809197 0.0 IIAFVGSPVEDNEKDLVK(ub)LAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIAFVGSPVEDNEKDLVKLAK 21 2 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 349140000.0 132710000.0 115990000.0 100440000.0 True False 171795711.10519168 109535054.53659561 82160950.60142928 1.0 0.6375889935315472 0.47824797297251254 27.356118779018193 -13.999999999999998 0.11157965430229215 2.7440851689338817 0.19247954022481858 0.9997350474096545 0.003553602703685881 12.00359735193663 0.1016182331710538 4.702839780361224 0.25373154941164416 1.0000000000000041e-14 13.999999999999998 -2.551605628709063 IIAFVGSPVEDNEKDLVKLAK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIAFVGSPVEDNEKDLVKLAK 21 2 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 145969000.0 57441000.0 80300400.0 8227600.0 True False 55617566.896613784 112364768.4810541 6072544.737290754 1.0 2.0203107534338276 0.10918393371250612 25.729037296652894 -6.761681302409704 1.606225361911051 1.591412623622402 0.10163488948445336 0.6977716802015914 0.42925318617127783 0.2800969154316198 1.4246318794605701 0.2108234214318758 0.50578735993793 1.7310862133193794e-07 6.761681302409704 -1.4897777341379486 IIAFVGSPVEDNEKDLVKLAK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIAFVGSPVEDNEKDLVKLAK 21 2 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 181798000.0 24781000.0 138233000.0 18784000.0 True False 37594588.73377205 113564241.13064134 15071334.166680327 1.0 3.0207602997030283 0.4008910503958091 25.164021683327995 -6.700670167649165 1.828321683473332 2.253917133455797 0.40849797975892216 0.4209766602934729 0.852871395420079 0.39404570381934145 2.561254309187229 0.37207086753038376 0.9561333821167218 1.9921857640496672e-07 6.700670167649165 -1.845419153696875 IIAFVGSPVEDNEKDLVKLAK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIAFVGSPVEDNEKDLVKLAK 21 2 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 145136100.0 57441000.0 9001700.0 78693400.0 True False 47764736.56776282 8953206.055402448 95147826.10282865 1.0 0.18744384872092248 1.9920098578968282 25.50944257208717 -6.784281075384755 1.5190352356272483 0.5424698378169754 2.008311599949698 0.782297034409611 0.34430548710524544 0.243978067010127 1.1121580322027598 0.17847062847672598 0.41966209184901265 1.643307830163479e-07 6.784281075384755 1.4658417621327224 IIAFVGSPVEDNEKDLVKLAK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIAFVGSPVEDNEKDLVKLAK 21 2 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 60655000.0 24781000.0 20392000.0 15482000.0 True False 32079493.006538663 19257167.27399134 12664434.858734863 1.0 0.600295249992455 0.3947828868789638 24.935148005420444 -11.163719695021292 0.11920815908150598 2.0453960447920747 2.8791371599154738e-21 0.9998080614349877 0.003481313387068389 3.600243893798227 0.07326218818089669 1.2826735957478614 0.2674444658173659 6.859308012308679e-12 11.163719695021292 -2.0453960447920747 IIALDGDTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIALDGDTK 9 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 19557240.0 861740.0 10218000.0 8477500.0 False True 1129749.48510203 8693514.229452034 7600329.621922156 1.0 7.695081382282644 6.72744685626987 20.107571468806277 -9.131216898283409 10.36128753080361 0.9999998876784062 7.2112641163777065 0.9821231931184318 0.3950351410433529 0.0 0.0 0.38249113060472456 0.12749704353490818 7.392359886198596e-10 9.131216898283409 6.2112642286993 IIALDGDTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIALDGDTK 9 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 13015600.0 5931900.0 1041900.0 6041800.0 False True 5743595.081457896 1457936.1034367234 4459271.329885179 1.0 0.25383685353157864 0.7763902689242645 22.453522613303374 -9.96660993204904 6.423229891790004 1.0000001116704076 0.515113561230711 0.5344595565515807 0.2133315385101631 3.412524979518277e-07 5.4627636416967395e-08 0.20655742321419118 0.06885245798921552 1.0799162293573737e-10 9.96660993204904 -0.48488655043969664 IIALDGDTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIALDGDTK 9 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 12602340.0 861740.0 5787700.0 5952900.0 False True 1180348.565647865 5531980.276635518 4546947.62382391 1.0 4.686734442379864 3.8522075225534755 20.17078153032917 -10.436383017354133 7.124194574545628 0.9996843829644835 4.26947098246667 0.9534126609839594 0.34069418836519627 0.0017080196123898787 0.00013512686679519883 0.3298986770191195 0.10995857647400485 3.661145448051079e-11 10.436383017354133 3.2697865995021864 IIALDGDTK(ub)NSTFSEIFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIALDGDTKNSTFSEIFK 18 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 6966100.0 0.0 1891900.0 5074200.0 True False 0.0 2647345.5361281643 3745114.797262963 0.0 IIALDGDTK(ub)NSTFSEIFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIALDGDTKNSTFSEIFK 18 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 7752400.0 0.0 3073100.0 4679300.0 True False 0.0 3056544.600337411 5657719.995361314 0.0 IIANALSSEPACLAEIEEDK(ub)AR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIANALSSEPACLAEIEEDKAR 22 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 63861800.0 8389800.0 17645000.0 37827000.0 True False 12727939.976538524 14496111.888985738 30350476.869836938 1.0 1.1389205099730588 2.3845553110544304 23.60149560142978 -6.928037757785195 0.7627237834399025 0.9796156741197856 2.62795455754912 0.9961384703147875 0.03868479864481514 0.09366923281321086 0.08276492129186332 0.03484100669553528 0.11394842155606752 1.1802180224304538e-07 6.928037757785195 1.6483388834293344 up IIAPPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIAPPER 7 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 102829000.0 2424000.0 62284000.0 38121000.0 False True 3177887.474049393 52991469.98113043 34176604.602452874 1.0 16.675061786755638 10.754504330797987 21.59963661046591 -9.521759740265258 11.587519393901319 0.9999988966138528 13.714783058776812 0.8601277631008376 2.417057459987873 0.0 0.0 2.34030582233982 0.7801019407799399 3.0077397796928497e-10 9.521759740265258 12.714784162162958 IIAPPER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIAPPER 7 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 108176000.0 35528000.0 10556000.0 62092000.0 False True 34400183.08704394 14771065.848812772 45828242.47992823 1.0 0.4293891637563977 1.3322092607463014 25.035912907571102 -6.735905954062578 1.7017561393816707 0.6588850773697639 1.3322719714600033 0.5863820250155929 0.23978097005223248 0.32528089069840943 1.8479868161312687 0.11154385991070652 0.2749509031893752 1.836936086538048e-07 6.735905954062578 0.6733868940902394 IIAPPER ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIAPPER 7 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 457007100.0 7160000.0 443770000.0 6077100.0 False True 10862243.46611549 364575776.3091645 4875958.521312447 1.0 33.563579885357015 0.4488905571416148 23.372818769487502 -3.0382373588317115 1.1269204873972084e-16 9.524910178668712 21.286313204899493 0.0 15.926256771264379 0.0 0.5027278008707509 1446999921.4427505 1446999936.8944867 0.0009157198767910102 3.0382373588317115 11.76140302623078 IIAPPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIAPPER 7 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 88459000.0 2424000.0 43695000.0 42340000.0 False True 3320218.3061369183 41764410.41995761 32340164.019671854 1.0 12.57881457456049 9.74037278208363 21.662846671988802 -9.223897011163995 10.300021913450289 0.999771286299114 11.15959367832234 0.9446955056963511 1.1587890168845403 0.0 0.0 1.1219926376404619 0.3739975458801539 5.971768846538185e-10 9.223897011163995 10.159822392023226 IIAPPER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIAPPER 7 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 39323300.0 35528000.0 2542300.0 1253000.0 False True 29543106.157265272 2528604.1252929587 1514996.50678258 1.0 0.08559032729438038 0.051280880849761644 24.81631818300538 -13.039008811362862 0.4794558594792522 9.999999996539138 0.05235878127684575 0.9999123216404179 0.004114084463346812 16.25037881241309 0.24026196666115984 151.40288520465646 0.007273901328220045 9.140946952945687e-14 13.039008811362862 -9.947641215262292 IIAPPER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIAPPER 7 0 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 21355100.0 7160000.0 8979600.0 5215500.0 False True 9268761.14470025 8479877.366297215 4266332.515549132 1.0 0.9148878942841129 0.4602915588118874 23.14394509157995 -6.938344185460664 0.6747917222598655 1.005278352046475 0.3434507563944558 0.997938883539523 0.010756130802540521 0.08853021753963831 0.058110880826515166 0.010343320859131996 0.039420177350032 1.152539489436353e-07 6.938344185460664 -0.6618275956520192 down IIAPPERK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIAPPERK 8 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 2787150.0 528450.0 1202900.0 1055800.0 False True 692803.0675170796 1023432.0088674757 946555.9439487372 1.0 1.4772336567956161 1.3662698511729696 19.402085792321717 -10.041597791908567 4.876149252661631 0.9999910516479122 1.4217517539898235 0.9506452837076916 0.04530078396790203 5977377.448917486 12323007.31071439 357.1917651428737 0.015507663219661079 9.086616688716607e-11 10.041597791908567 0.4217607023419112 IIAPPERK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIAPPERK 8 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 3740700.0 770800.0 1355000.0 1614900.0 False True 746331.375914588 1896058.5662316503 1191909.2440384615 1.0 2.540504965248359 1.597024167150741 19.50945681301235 -9.981251971555416 6.043480028066597 0.9999992550989695 2.0687645661996803 0.631125288065371 0.3851744229092972 3.86623706870389e-06 6.510434179513835e-07 0.3729437869223719 0.12431451044266215 1.0441142630313167e-10 9.981251971555416 1.068765311100711 IIAPPERK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIAPPERK 8 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 24080140.0 830640.0 21565000.0 1684500.0 False True 1260141.60791818 17716557.26188596 1351557.8366574203 1.0 14.059179659304037 1.0725444094257506 20.265154434447762 -6.644858681773383 2.0270209093601994 9.50821782169253 1.126585576384407 0.1736010602408451 5.580866407967219 0.5210627683141891 4.0976200986557485 2.2375575647927475 6.18002295166736 2.265381336511895e-07 6.644858681773383 -8.381632245308122 IIAPPERK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIAPPERK 8 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 3054250.0 528450.0 1702400.0 823400.0 False True 723832.2458242797 1627182.3389160293 628929.8784553093 1.0 2.2480102928587273 0.8688890030577482 19.46529585384461 -6.668410600718867 1.943247293902697 1.7976918242581803 0.8745278243802406 0.2719563449449206 0.5303233778361878 0.464755613103802 3.3820356370955618 0.21983694365774067 0.588517773351756 2.145800782271012e-07 6.668410600718867 -0.9231639998779397 IIAPPERK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIAPPERK 8 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 0 3419100.0 770800.0 2019800.0 628500.0 False True 640954.3522297929 2008918.9365010916 759916.4441443331 1.0 3.134262103864864 1.1856015042267634 19.289862088446625 -6.624562273239942 2.100951643639818 2.411642189683277 1.1933496063282711 0.09810972263636486 0.9167560005371888 0.5732062901176637 4.8144047698992045 0.3578477438591493 1.01553675421021 2.3737650255074454e-07 6.624562273239942 -1.218292583355006 IICILSHPIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IICILSHPIK 10 0 P31150 P31150 GDI1 Rab GDP dissociation inhibitor alpha 0 3620780.0 843380.0 1434300.0 1343100.0 False True 1155200.3774875212 1370927.8834041725 1025887.4420127823 1.0 1.1867446636278316 0.8880601686124919 20.139711688094796 -6.737673808438046 1.6954061965753733 1.1114115277505212 0.8879788450570879 0.5943815244941846 0.07846739275478885 0.3220360096318712 1.816657962250784 0.03662916417868562 0.09010851494514496 1.829473788420468e-07 6.737673808438046 -0.2234326826934333 IICITNAK(ub)SDSHVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IICITNAKSDSHVR 14 1 Q9NVM9;Q9NVM9-2;F5H457;F8VRX9 Q9NVM9 ASUN Protein asunder homolog 1 22182200.0 7549000.0 9321600.0 5311600.0 True False 9896812.10462 7930853.615312219 4762006.584464959 1.0 0.8013543686062263 0.4811657061006517 23.238532458001103 -6.964034345552318 0.37425446108753785 1.0234652532693285 0.24783460396654103 0.9998918356036954 0.002222952068022077 0.0782901804445562 0.016024728555254157 0.004195010984588439 0.02713280204587711 1.0863397086118515e-07 6.964034345552318 -0.7756306493027875 down IICITNAK(ub)SDSHVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IICITNAKSDSHVR 14 1 Q9NVM9;Q9NVM9-2;F5H457;F8VRX9 Q9NVM9 ASUN Protein asunder homolog 1 10361100.0 6072000.0 2595500.0 1693600.0 True False 5879247.683644753 3631896.685353694 1249995.3530890706 1.0 0.6177485421233612 0.21261144628527615 22.487200127019456 -7.551328425577505 0.36283648676627056 1.054631420773472 2.0131429009530184e-12 0.9991964998870008 0.009113128522294548 0.12232002956339445 0.044793247812008 0.022276909978902436 0.06885987660629696 2.8097751965437593e-08 7.551328425577505 -1.0546314207714589 down IICITNAK(ub)SDSHVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IICITNAKSDSHVR 14 1 Q9NVM9;Q9NVM9-2;F5H457;F8VRX9 Q9NVM9 ASUN Protein asunder homolog 1 18909100.0 7549000.0 5529900.0 5830200.0 True False 10340069.304054296 5285570.733066115 4453226.836738096 1.0 0.5111736273366819 0.43067669140205905 23.301742519523994 -13.999999999999998 0.25382664915409 4.4662154702938155 0.3994682138841891 0.999550012226607 0.005336402662709362 14.152962085340704 0.1594206101160138 25.070106056397268 0.03637493477888822 1.0000000000000041e-14 13.999999999999998 -4.066747256409626 IICITNAK(ub)SDSHVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IICITNAKSDSHVR 14 1 Q9NVM9;Q9NVM9-2;F5H457;F8VRX9 Q9NVM9 ASUN Protein asunder homolog 1 30899500.0 15390000.0 7388900.0 8120600.0 True False 19922658.382253766 6977701.219634886 6642734.124392348 1.0 0.35023946532408134 0.3334260918868842 24.247906830643906 IICNTK(ub)DNER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IICNTKDNER 10 1 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 1 9002900.0 3536200.0 4185400.0 1281300.0 True False 4635992.4446095135 3560954.6345614204 1148723.3670974758 1.0 0.7681105344988018 0.2477837012942397 22.144446784475015 -6.993875594032429 0.47712851464975403 1.0128221244682951 4.479552701592798e-13 0.9996723659508657 0.005693135112183801 0.07582796008441321 0.02458552255536463 0.007139811132463555 0.040278009266122176 1.014201867656691e-07 6.993875594032429 -1.0128221244678473 down IICNTK(ub)DNER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IICNTKDNER 10 1 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 1 6923440.0 4012900.0 2300700.0 609840.0 True False 3885512.6860504053 3219381.507992001 450104.60919215716 1.0 0.8285602874364768 0.11584175514549282 21.889673541399276 -7.083889458823769 0.7073525201588686 1.0007092312988837 1.0952388298084932e-21 0.9975933198553112 0.018781313545822065 0.0771682477432371 0.06322978528797012 0.017879080047960873 0.05203872948168995 8.243479099687416e-08 7.083889458823769 -1.0007092312988837 down IICNTK(ub)DNER ddPTM_RPMI8226_Bortezomib_8h_R1 1 IICNTKDNER 10 1 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 1 20274900.0 3185400.0 1920500.0 15169000.0 True False 4832484.683933564 1577771.770065011 12170840.501191113 1.0 0.3264928651115207 2.5185471444234864 22.20433372929341 -6.824219717268809 1.3535405564175806 0.6384551280641072 2.5708702623969306 0.8938207553962308 0.29874069993515207 0.18804570079160393 0.675769612050853 0.1733887175438415 0.39925087161142425 1.498926310279774e-07 6.824219717268809 1.9324151343328233 up IICNTK(ub)DNER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IICNTKDNER 10 1 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 1 8357400.0 3536200.0 3389600.0 1431600.0 True False 4843628.702211785 3239836.264091738 1093485.5647274982 1.0 0.6688861725945892 0.22575751197199964 22.207656845997906 -7.317935146801141 0.3975325964273065 1.0330514530468484 2.5296106349609095e-12 0.9994526770729234 0.0074204947879604405 0.1041538453239634 0.03338825263155232 0.012490822425333588 0.053514910840003996 4.809111575554178e-08 7.317935146801141 -1.033051453044319 down IICNTK(ub)DNER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IICNTKDNER 10 1 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 1 6900400.0 4012900.0 1416100.0 1471400.0 True False 3336904.15161253 1408471.1882261587 1779062.9370150717 1.0 0.4220891953236137 0.5331477489862437 21.670078816833552 -9.974004423466695 6.082805956066871 1.0000002999547906 0.47761847215524666 0.9672122611160643 0.04533946467436752 1.8442865486120487e-07 3.113344968828067e-08 0.043899773086617834 0.014633249300784667 1.0616847434508728e-10 9.974004423466695 -0.5223818277995439 IICNTK(ub)DNER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IICNTKDNER 10 1 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 1 11247500.0 3185400.0 1237900.0 6824200.0 True False 4123563.093621259 1169009.776798445 5582265.622205043 1.0 0.28349506246352496 1.3537480803531905 21.97546005138586 -6.726266817287956 1.736565767633927 0.5670376538495345 1.3527234519484257 0.5420099117446873 0.3013000229725617 0.3432754574222126 2.0262182118693848 0.13758604462602772 0.3428988917031985 1.8781625764531126e-07 6.726266817287956 0.7856857980988912 IIDCAFTVTFNPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIDCAFTVTFNPK 13 0 P50579;F8VQZ7;P50579-3;G3V1U3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 0 5446900.0 1870400.0 2299200.0 1277300.0 False True 2452112.512979368 1956168.3222114055 1145137.2487267682 1.0 0.7977481913481286 0.4670002875746523 21.225593746637255 -6.9637820178293355 0.3783737808036153 1.0231387050841068 0.22994380081275753 0.9998857945617762 0.002347794418815701 0.07837673376815157 0.01633240286201231 0.004311845391366252 0.02796989119643111 1.0869710619509961e-07 6.9637820178293355 -0.7931949042713492 down IIDCAFTVTFNPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIDCAFTVTFNPK 13 0 P50579;F8VQZ7;P50579-3;G3V1U3;F8VRR3;P50579-2 P50579 METAP2 Methionine aminopeptidase 2 0 9242600.0 1870400.0 2352200.0 5020000.0 False True 2561937.4256594456 2248272.026314784 3834379.390145314 1.0 0.8775671114356262 1.4966717577648643 21.288803808160147 -6.855329479982276 1.20902881872107 0.9342304022446782 1.5240958216898508 0.9477131687591351 0.061212818417600456 0.15169382776925183 0.42402143517964497 0.039555452334934654 0.09190610257254753 1.395309399989839e-07 6.855329479982276 0.5898654194451726 IIDDSEITK(ub)EDDALWPPPDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIDDSEITKEDDALWPPPDR 20 1 P61326;Q96A72;F5H6P7;F5H6N1;F5H3U9 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 13818900.0 3901900.0 5946400.0 3970600.0 True False 5115428.6860533515 5059220.298885653 3559760.4006846505 1.0 0.9890119889031109 0.6958870153717405 22.286423715908295 -6.9148242164510885 0.8622278317775479 1.0077504880213852 0.6538190379835415 0.9926184713172922 0.012100537157529343 0.10131382596883344 0.12209961725098377 0.010149535172070394 0.029048868206865506 1.2166783595678379e-07 6.9148242164510885 -0.35393145003784376 IIDDSEITK(ub)EDDALWPPPDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIDDSEITKEDDALWPPPDR 20 1 P61326;Q96A72;F5H6P7;F5H6N1;F5H3U9 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 25387500.0 9326400.0 8435200.0 7625900.0 True False 9030338.53701325 11803419.348986873 5628448.017903832 1.0 1.307084922742089 0.6232820613351467 23.10634864302313 -6.784637694893138 1.5178616696087999 1.1728364376159 0.6170637459215734 0.7834132424905366 0.13014291554468188 0.2434487037541576 1.1080765731469606 0.06751304880035697 0.1586922670583584 1.6419589871315314e-07 6.784637694893138 -0.5557726916943265 IIDDSEITK(ub)EDDALWPPPDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIDDSEITKEDDALWPPPDR 20 1 P61326;Q96A72;F5H6P7;F5H6N1;F5H3U9 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 51101000.0 12446000.0 12590000.0 26065000.0 True False 18881491.924479518 10343216.133881018 20913241.325304676 1.0 0.5477965499363544 1.1076053422553453 24.170469428223257 -6.69176843447282 1.860282871529734 0.7169687083182165 1.1057061827643073 0.3786899059546258 0.19118180416607258 0.4128545569041167 2.7714827426412527 0.08217608207194375 0.21350455509877264 2.0334409512871298e-07 6.69176843447282 0.38873747444609086 IIDDSEITK(ub)EDDALWPPPDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIDDSEITKEDDALWPPPDR 20 1 P61326;Q96A72;F5H6P7;F5H6N1;F5H3U9 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 14591700.0 3901900.0 5038400.0 5651400.0 True False 5344537.87488269 4815786.828239259 4316655.7142365 1.0 0.9010670222530631 0.8076761387590032 22.349633777431187 -6.97182275827287 0.21013874656499815 1.0488090893675759 0.657326547973988 0.9999933195241963 0.00020288295504360056 0.07571556672151294 0.006872070481350002 0.0027935487446689475 0.0096744578840799 1.0670315030456946e-07 6.97182275827287 -0.39148254139358785 IIDDSEITK(ub)EDDALWPPPDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIDDSEITKEDDALWPPPDR 20 1 P61326;Q96A72;F5H6P7;F5H6N1;F5H3U9 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 22310800.0 9326400.0 8434200.0 4550200.0 True False 7755314.82957439 8388763.290542379 5501625.78225226 1.0 1.081679270911398 0.7094007017319486 22.886753918457405 -6.849196120763203 1.2388805123247093 1.0435615794634576 0.6947413624734864 0.9391329553898704 0.03941491050433647 0.158349469340403 0.46808030925482913 0.02489935566264024 0.05759269449801782 1.4151545734217087e-07 6.849196120763203 -0.34882021698997123 IIDDSEITK(ub)EDDALWPPPDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIDDSEITKEDDALWPPPDR 20 1 P61326;Q96A72;F5H6P7;F5H6N1;F5H3U9 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 39258000.0 12446000.0 12517000.0 14295000.0 True False 16111592.347337889 11820417.9466727 11693456.679086337 1.0 0.7336591996523412 0.7257790804903552 23.941595750315706 IIDGLLVMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIDGLLVMR 9 0 C9JQD4;O43447;O43447-2;H0YEL5 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 0 11466300.0 2840400.0 3487500.0 5138400.0 False True 3723791.9064727277 2967178.59416853 4606727.659013243 1.0 0.7968164356904461 1.2371066307453402 21.828341023561368 -6.781228328192895 1.5311468349621669 0.8851368730105289 1.24072623877964 0.771702616362833 0.08596924464948785 0.24866470077192407 1.1515662539317937 0.044219674146201295 0.10423051799581695 1.654899679329505e-07 6.781228328192895 0.35558936576911115 IIDGLLVMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIDGLLVMR 9 0 C9JQD4;O43447;O43447-2;H0YEL5 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 0 11011300.0 4349400.0 1998900.0 4663000.0 False True 4211330.6777411895 2797071.1941257943 3441620.41299854 1.0 0.6641775268110852 0.8172287280096715 22.005844731083133 -10.180846876813375 5.149294511131232 1.0000156941041016 0.7407031274101994 0.7928324947492071 0.06248289124338721 1.125831300090374e-05 1.7910383130341473e-06 0.06050245923299468 0.02016626643395436 6.594063472036099e-11 10.180846876813375 -0.25931256669390224 IIDGLLVMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIDGLLVMR 9 0 C9JQD4;O43447;O43447-2;H0YEL5 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 0 12704900.0 2840400.0 4561100.0 5303400.0 False True 3890572.638923803 4359575.520459291 4050846.1469515297 1.0 1.1205485477493158 1.0411953516621812 21.89155108508426 -10.798657823206076 6.410268672815892 0.995858665606216 1.080871949705209 0.580688080111738 0.03239580664541639 0.0020083162486508616 6.307973823120033e-05 0.03285483242222674 0.010455701635387754 1.5897988437703354e-11 10.798657823206076 0.085013284098993 IIDGLLVMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIDGLLVMR 9 0 C9JQD4;O43447;O43447-2;H0YEL5 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 0 8231000.0 4349400.0 1564500.0 2317100.0 False True 3616718.811090116 1556071.727971066 2801594.896940076 1.0 0.4302440441871261 0.7746233653413732 21.78625000651741 -10.410284897838217 6.053589288836585 1.000107032712773 0.6024337047642687 0.6398972056632259 0.14059226913232745 0.00020314618614395146 1.9789635023990338e-05 0.13616422193888367 0.04537595974625119 3.887900144817932e-11 10.410284897838217 -0.3976733279485043 IIDK(ub)EGDDYEVIPNSNFYVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIDKEGDDYEVIPNSNFYVSR 21 1 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 5002500.0 1733100.0 3269400.0 0.0 True False 2272110.883364275 2781618.2640213836 0.0 1.0 1.2242440650179405 0.0 21.11560181216688 -6.906951707850083 1.284569674418786 1.1170706036723435 4.416557024049568e-23 0.951531057274693 0.11716569040149397 0.13004143819667913 0.4303031890058216 0.07467412616958266 0.14775443007304087 1.238934344386424e-07 6.906951707850083 -1.1170706036723435 down IIDK(ub)EGDDYEVIPNSNFYVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIDKEGDDYEVIPNSNFYVSR 21 1 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 98286700.0 6436700.0 29660000.0 62190000.0 True False 9764944.48580247 24366941.26536227 49898119.24115472 1.0 2.495348673081558 5.109923493543974 23.21918041166613 -6.962585608700153 0.39731715816203156 0.8519507829201483 6.848377046259577 0.9998544028908469 0.020494487352407168 0.07879009347874774 0.017810938277311197 0.03365834719639676 0.2192817777532855 1.0899696149615863e-07 6.962585608700153 5.996426263339428 IIDK(ub)EGDDYEVIPNSNFYVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIDKEGDDYEVIPNSNFYVSR 21 1 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 10459800.0 1733100.0 3147100.0 5579600.0 True False 2373873.9052664572 3008050.7159320014 4261813.395469087 1.0 1.267148482174482 1.7952989777655088 21.17881187368977 -6.960270475669111 0.4316044782597035 0.9793745976066294 2.1033803277828405 0.9997801006356222 0.004900333015205375 0.07960463422586443 0.020775309037316204 0.006897814128682443 0.04383675184354034 1.0957955295328915e-07 6.960270475669111 1.124005730176211 IIDK(ub)EGDDYEVIPNSNFYVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIDKEGDDYEVIPNSNFYVSR 21 1 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 86679700.0 6436700.0 27848000.0 52395000.0 True False 8332435.036325727 26298234.319640607 42859647.61809929 1.0 3.1561283352335723 5.143712183923451 22.99030673375858 -7.137920694216307 0.2189063340491465 8.349354307957123e-24 8.02766567237678 0.9999888807513022 0.005642494843078294 0.0834888208684029 0.009198785455134134 0.07651322153305226 0.23725577954247629 7.279127153157917e-08 7.137920694216307 8.02766567237678 IIDK(ub)NGIHDLDNISFPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIDKNGIHDLDNISFPK 17 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 66423400.0 8295300.0 22116000.0 36012100.0 True False 10875218.631799478 18816379.00749278 32285913.344455652 1.0 1.730206963607435 2.9687599337130233 23.37454106892852 -6.963134899521334 0.38874149465959884 0.9228578039173203 3.820521527449381 0.9998693771415701 0.009287515914571134 0.07859976923799739 0.017128384495896175 0.016003015432739895 0.10424091779048339 1.0885919049783599e-07 6.963134899521334 2.8976637235320606 IIDK(ub)NGIHDLDNISFPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIDKNGIHDLDNISFPK 17 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 172715300.0 18164500.0 38171800.0 116379000.0 True False 17587877.8902446 53413998.80330726 85895848.60483742 1.0 3.036978033201731 4.883809697841997 24.06807808551414 -7.146533425278635 0.21324270413806604 9.762016698759893e-13 7.651969203446474 0.9999895548407784 0.0051264060397344996 0.08477210648843667 0.009104666495646285 0.0762275453251806 0.22802687276298872 7.136192796233184e-08 7.146533425278635 7.651969203445498 IIDK(ub)NGIHDLDNISFPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIDKNGIHDLDNISFPK 17 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 881405000.0 28960000.0 157155000.0 695290000.0 True False 43934437.259595625 129109462.3923807 557865626.7435668 1.0 2.938684786822487 12.697684585039827 25.38884887930645 -6.939655197813831 0.6627659967708296 0.8897821374953809 15.302873363834859 0.9981183505816384 0.222049518694689 0.08792438409999338 0.055329198858941046 0.215587386862504 0.8412223731739327 1.1490655443762894e-07 6.939655197813831 14.413091226339478 IIDK(ub)NGIHDLDNISFPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIDKNGIHDLDNISFPK 17 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 58661600.0 8295300.0 3580300.0 46786000.0 True False 11362296.582053458 3422110.507531164 35736110.38791607 1.0 0.30118123416495973 3.145148529599255 23.43775113045141 -6.841709984662979 1.2743106607574082 0.6282668393031637 3.241966822756817 0.9273666598894011 0.32611752598550997 0.16681657036902142 0.525443071417302 0.20060447849092045 0.46241856971073225 1.4397597072306104e-07 6.841709984662979 2.613699983453653 up IIDK(ub)NGIHDLDNISFPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIDKNGIHDLDNISFPK 17 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 111886600.0 18164500.0 33115100.0 60607000.0 True False 15104586.573790967 32936702.383467335 73279643.4848937 1.0 2.1805762258080024 4.851482900700266 23.848483360948418 -6.957564466415958 0.46849769424822885 0.9284142767920176 6.2128625245725075 0.9996689333250637 0.029314744885058138 0.0805828809045296 0.02443486933075677 0.036826252287577146 0.22046923772626364 1.1026445457969383e-07 6.957564466415958 5.28444824778049 IIDK(ub)NGIHDLDNISFPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIDKNGIHDLDNISFPK 17 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 623024000.0 28960000.0 141744000.0 452320000.0 True False 37489290.88694404 133855821.79700996 370002401.195127 1.0 3.5705082339561236 9.869549208357618 25.1599752013989 -6.955889131920216 0.4899509703806046 0.8620889691540169 12.845051847663425 0.9995860318635104 0.07581198384641707 0.08120370308225915 0.026816698891229663 0.09068333076414074 0.5195257022516694 1.106906322487066e-07 6.955889131920216 11.982962878509408 IIDK(ub)NGIHDLDNISFPK(ub)QGS ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIDKNGIHDLDNISFPKQGS 20 2 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 2 17601300.0 3141700.0 4347600.0 10112000.0 True False 4118799.1242660834 3698955.02681207 9065707.241153263 1.0 0.8980663817809216 2.2010559310218007 21.973792336343177 -6.887995991560914 1.034195928299573 0.9265880890222586 2.308809175632466 0.9795831444931553 0.0845429155045969 0.12078289540612118 0.23148186425003578 0.06244668377790099 0.15459427450560986 1.2942077866377612e-07 6.887995991560914 1.3822210866102074 up IIDK(ub)NGIHDLDNISFPK(ub)QGS ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIDKNGIHDLDNISFPKQGS 20 2 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 2 42539500.0 6595500.0 7209000.0 28735000.0 True False 6386129.46269417 10087591.294438364 21208441.468478028 1.0 1.5796095825126957 3.3210165237600187 22.606510369537794 -6.951417850039111 0.543060901097674 0.9748655505987767 4.006600867579272 0.9993078674779484 0.025948687989208893 0.08292147423568137 0.03364524711787842 0.02842212692368958 0.1442853565032276 1.1183613507636781e-07 6.951417850039111 3.0317353169804955 IIDK(ub)NGIHDLDNISFPK(ub)QGS ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIDKNGIHDLDNISFPKQGS 20 2 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 2 18636700.0 3141700.0 5848500.0 9646500.0 True False 4303271.39125015 5590093.931596801 7368195.375903741 1.0 1.2990335545564589 1.7122311622932977 22.03700239786607 -6.966585542095421 0.3297080201292307 0.9494876854968901 2.075297737918165 0.9999421968513713 0.002220094378129479 0.07742695521732208 0.012984645340804344 0.006035492868591088 0.0360485077932118 1.0799768790949588e-07 6.966585542095421 1.125810052421275 IIDK(ub)NGIHDLDNISFPK(ub)QGS ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIDKNGIHDLDNISFPKQGS 20 2 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 2 38941100.0 6595500.0 8876000.0 23469600.0 True False 5484450.48019149 8828183.226251943 28376984.84883031 1.0 1.6096750728513656 5.174079873876357 22.38691564497207 -6.936385938939375 0.6923661536695164 0.9564114211622972 6.041034114360121 0.9976512237025782 0.08921684145943545 0.08945467708045281 0.06241122827043119 0.0846296411435123 0.31197703092360557 1.1577480576725696e-07 6.936385938939375 5.084622693197824 IIDKNGIHDLDNISFPK(ub)QGS ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIDKNGIHDLDNISFPKQGS 20 2 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 109859700.0 8505700.0 21134000.0 80220000.0 True False 12903768.749963481 17362472.579304338 64364481.83832502 1.0 1.3455350073096648 4.988037455220761 23.62128915333305 -6.925349336449538 0.784022221858469 0.9340347046677863 5.654355994001324 0.995542604999179 0.12044570201526537 0.0951257727992093 0.09004364937964109 0.10683421644436901 0.33840245627099147 1.1875466080888979e-07 6.925349336449538 4.720321289333538 up IIDKNGIHDLDNISFPK(ub)QGS ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIDKNGIHDLDNISFPKQGS 20 2 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 121422700.0 8505700.0 19610000.0 93307000.0 True False 11010796.322412977 18518686.26142457 76326083.41066869 1.0 1.6818662083258178 6.931931276878083 23.392415475425498 -6.930815402143498 0.7400670460055437 0.9225283502068988 8.032474168008047 0.9966960908190504 0.15233723646415828 0.09221673745845893 0.07562187502965682 0.1394655249337146 0.4729287241174383 1.172693715757106e-07 6.930815402143498 7.109945817801148 up IIDSEYTAQEGAK(ub)FPIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIDSEYTAQEGAKFPIK 17 1 E9PJX5;P51451 E9PJX5 BLK Non-specific protein-tyrosine kinase;Tyrosine-protein kinase Blk 1 5159000.0 1835600.0 1405600.0 1917800.0 True False 2514270.925224806 1343495.944302378 1464855.1383308128 1.0 0.5343481208900561 0.5826162660652161 21.261708685040762 -10.49774616130777 9.557325954267412 1.0000069943051135 0.5584821938832333 0.9911159592156444 0.01970538775162062 2.936810381900107e-06 1.5432141690837584e-07 0.019079961560516605 0.006359886549382188 3.1787314492428633e-11 10.49774616130777 -0.44152480042188025 IIDVSTVK(ub)ELCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIDVSTVKELCR 12 1 H0YG54;H0YGR4;F5GYG5;Q9Y3B8-2;Q9Y3B8-3;Q9Y3B8 H0YG54 REXO2 Oligoribonuclease, mitochondrial 1 9748000.0 2432600.0 3145000.0 4170400.0 True False 3189162.157331907 2675778.2591139833 3738887.0133015774 1.0 0.8390223284703003 1.172372814190664 21.604746024591016 -6.775387225725155 1.5537850533925832 0.9083048299036448 1.1746442147002085 0.750756885700836 0.06795503093794214 0.25780400282936106 1.2289805522676924 0.03445842865261285 0.08162845340863766 1.6773078296927855e-07 6.775387225725155 0.2663393847965637 IIDVSTVK(ub)ELCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIDVSTVKELCR 12 1 H0YG54;H0YGR4;F5GYG5;Q9Y3B8-2;Q9Y3B8-3;Q9Y3B8 H0YG54 REXO2 Oligoribonuclease, mitochondrial 1 7197500.0 3256200.0 2391800.0 1549500.0 True False 3152833.713353769 3346858.213072227 1143639.4659964044 1.0 1.0615397186653615 0.36273383564522943 21.588217650780184 -6.88543481105355 1.048990436100375 1.0417586642089478 0.3077379447521047 0.9778126083358502 0.04705702069591718 0.1229262450261348 0.24410053885754793 0.03436838810836756 0.08438885789758595 1.3018627145383446e-07 6.88543481105355 -0.7340207194568431 down IIDVSTVK(ub)ELCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIDVSTVKELCR 12 1 H0YG54;H0YGR4;F5GYG5;Q9Y3B8-2;Q9Y3B8-3;Q9Y3B8 H0YG54 REXO2 Oligoribonuclease, mitochondrial 1 31385100.0 3877800.0 9155300.0 18352000.0 True False 5882906.105153997 7521465.184314599 14724719.156032646 1.0 1.2785288511956812 2.5029668828357403 22.488097579447615 -6.942711815144116 0.6338318001513992 0.9866357113544294 2.86128552032931 0.9984979743621077 0.02530123824580263 0.086550950191362 0.04913708784683396 0.02516797078864622 0.10419126775576529 1.1410066743833496e-07 6.942711815144116 1.8746498089748806 up IIDVSTVK(ub)ELCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIDVSTVKELCR 12 1 H0YG54;H0YGR4;F5GYG5;Q9Y3B8-2;Q9Y3B8-3;Q9Y3B8 H0YG54 REXO2 Oligoribonuclease, mitochondrial 1 9729700.0 2432600.0 2588100.0 4709000.0 True False 3331997.9585431754 2473749.1842978 3596831.184899257 1.0 0.7424221788477262 1.0794818093081524 21.667956086113907 -6.702498841703232 1.8221085620188462 0.8404439423167969 1.078521659369299 0.4293373052300652 0.10867841818532127 0.39036793580191587 2.5214440141056387 0.047553550569389466 0.12191253955478663 1.983814947816415e-07 6.702498841703232 0.23807771705250214 IIDVSTVK(ub)ELCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIDVSTVKELCR 12 1 H0YG54;H0YGR4;F5GYG5;Q9Y3B8-2;Q9Y3B8-3;Q9Y3B8 H0YG54 REXO2 Oligoribonuclease, mitochondrial 1 8991500.0 3256200.0 1824900.0 3910400.0 True False 2707674.5741186496 1815068.9014857092 4728046.560353226 1.0 0.6703423368653952 1.7461649954342129 21.36862292621446 -6.824452087172186 1.3524143047460102 0.8230648424923815 1.7719864309578939 0.8943248385197893 0.14629799705755744 0.18776732889830228 0.6735586440428831 0.08497670373641943 0.1956730166486583 1.4981245220637912e-07 6.824452087172186 0.9489215884655123 IIDVSTVK(ub)ELCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIDVSTVKELCR 12 1 H0YG54;H0YGR4;F5GYG5;Q9Y3B8-2;Q9Y3B8-3;Q9Y3B8 H0YG54 REXO2 Oligoribonuclease, mitochondrial 1 20734500.0 3877800.0 6276700.0 10580000.0 True False 5019888.542865728 5927396.127337266 8654548.559967369 1.0 1.1807824171238401 1.7240519358277833 22.259223901540064 -6.951412472611245 0.5431160002433258 0.9921615332127709 1.9378953376141514 0.9993075155933476 0.008096971516941259 0.08292347883172838 0.033653108905305554 0.008868122723414187 0.04501339787417051 1.1183751983831513e-07 6.951412472611245 0.9457338044013806 IIDVVYNASNNELVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIDVVYNASNNELVR 15 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 77189000.0 25974000.0 28069000.0 23146000.0 False True 34052165.532573834 23881214.612105027 20751073.952109706 1.0 0.7013126548225129 0.6093907282419238 25.02124321292647 -13.999999999999998 0.16504775843974467 2.4877674857349787 0.5238773587775866 0.9995240095536633 0.0036379367081868642 12.047163862675955 0.12853700798663384 5.7368313868422005 0.07846174557448188 1.0000000000000041e-14 13.999999999999998 -1.9638901269573923 IIDVVYNASNNELVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIDVVYNASNNELVR 15 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 77464000.0 31036000.0 11134000.0 35294000.0 False True 30050779.16824751 15579864.263042947 26049442.602695823 1.0 0.5184512579795291 0.8668474935991141 24.840899062389045 -10.392888331801972 5.657424183816155 1.000112964044312 0.6926493757893788 0.5092438413909759 0.14223216759574442 0.00020273231288966788 2.1755682759699856e-05 0.137766020592152 0.04590523469944116 4.0467993186238657e-11 10.392888331801972 -0.30746358825493325 IIDVVYNASNNELVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIDVVYNASNNELVR 15 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 131087000.0 11101000.0 105820000.0 14166000.0 False True 16841028.5918084 86935594.2245662 11366083.890821619 1.0 5.162130908491677 0.6749043758734644 24.005476920132654 -6.663052115556235 1.9621473015647193 3.67234089250356 0.6935201547862941 0.24866580326287546 1.7708530642949123 0.47722077337438445 3.5351212768599707 0.7283623362601378 1.9637013461115747 2.1724404692725826e-07 6.663052115556235 -2.9788207377172657 IIDVVYNASNNELVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIDVVYNASNNELVR 15 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 83090000.0 25974000.0 28368000.0 28748000.0 False True 35577289.72095724 27114607.95956878 21958314.48364495 1.0 0.762132477550604 0.6172003167152481 25.084453274449363 -10.992905975705783 0.06987687098242773 1.9986574722335946 6.644632709362306e-12 0.9999693488759264 0.0008736442051899482 3.3750647112377217 0.04314134472422578 0.9306415035578315 0.38932724283650566 1.0164687334521095e-11 10.992905975705783 -1.99865747222695 IIDVVYNASNNELVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIDVVYNASNNELVR 15 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 53630000.0 31036000.0 11485000.0 11109000.0 False True 25807809.127924073 11423128.025405992 13431840.53778744 1.0 0.44262292737767334 0.5204564429010046 24.62130433782332 -10.656293303739263 6.654494172188068 1.0026762169180823 0.4815396851395517 0.9833779720414564 0.03177539965319252 0.0012660015609721317 6.538925094830442e-05 0.030873202364291405 0.0102554661396583 2.2065140453985232e-11 10.656293303739263 -0.5211365317785306 IIDVVYNASNNELVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIDVVYNASNNELVR 15 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 48782000.0 11101000.0 19622000.0 18059000.0 False True 14370463.33342424 18530018.450875744 14772447.30098779 1.0 1.2894517052749999 1.0279729301858052 23.776603242225104 -10.538639242029118 3.450939452904719 0.995941301462256 1.1587123177619194 0.3294137691725266 0.10674826303923386 77533098.34949704 10785.87265530095 2500993.4541382524 0.03654276357092637 2.893082098146606e-11 10.538639242029118 0.1627710162996634 IIEDK(ub)TFGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIEDKTFGLK 10 1 Q8WU90;F8WB26;F8WF67 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 1 5973810.0 1815200.0 3267600.0 891010.0 True False 1509419.2269947075 3249996.79023218 1077316.0714352306 1.0 2.153143892769279 0.7137288648298158 20.525562125823242 -6.6933916097594 1.8541631736191946 1.720650531404039 0.7184711249367645 0.3863327859387913 0.4873711550216486 0.40947721062907405 2.731889081878088 0.21006423385276826 0.5447353529243855 2.0258551521111285e-07 6.6933916097594 -1.0021794064672744 IIEDQQESLNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIEDQQESLNK 11 0 P05455 P05455 SSB Lupus La protein 0 13598640.0 314640.0 7234900.0 6049100.0 False True 412496.0869780948 6155481.1214193255 5423197.159064507 1.0 14.922520032889926 13.14726934452714 18.654020908161147 -9.518267782081491 9.936871037302978 0.9999991872133692 14.034894687612008 0.9862796353079919 0.7247430586690593 0.0 0.0 0.7017294491261025 0.23390981637536745 3.03202109070778e-10 9.518267782081491 13.034895500398639 IIEDQQESLNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIEDQQESLNK 11 0 P05455 P05455 SSB Lupus La protein 0 13030970.0 4415300.0 871370.0 7744300.0 False True 4275138.718313028 1219312.5851345204 5715835.505979977 1.0 0.2852100634562945 1.336994161498331 22.027539802182453 -6.723722308859029 1.7460299456831068 0.5668588402224494 1.3356934896882058 0.5299364463234184 0.30065808617951284 0.34815403199950995 2.076244024829924 0.13662461737085937 0.3414724427146601 1.8891989309174892e-07 6.723722308859029 0.7688346494657564 IIEDQQESLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIEDQQESLNK 11 0 P05455 P05455 SSB Lupus La protein 0 13312740.0 314640.0 6351900.0 6646200.0 False True 430970.91082628747 6071252.055075621 5076504.442785619 1.0 14.087382471906036 11.779227588824012 18.71723096968404 -9.97538279469293 9.966469954584973 0.999999405139696 12.933305030365025 0.9727069730328702 0.9423002851441162 2.180647588062317e-08 1.0912988551962023e-08 0.9123783278723867 0.30412610929079564 1.0583204919064523e-10 9.97538279469293 11.933305625225328 IIEDQQESLNK(ub)WK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIEDQQESLNKWK 13 1 P05455 P05455 SSB Lupus La protein 1 212490000.0 63812000.0 75956000.0 72722000.0 True False 83658149.95628698 64623660.87416903 65197425.03868159 1.0 0.7724729856916052 0.7793314228529858 26.31800275831586 -10.508025442761577 6.136530866205162 1.0002144966574502 0.7759022042722955 0.9992980061795389 0.0027999452463875383 8.224437971887416e-06 6.593697858346065e-07 0.0027136052622369245 0.000903678442462619 3.10437771555341e-11 10.508025442761577 -0.2243122923851547 IIEDQQESLNK(ub)WK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIEDQQESLNKWK 13 1 P05455 P05455 SSB Lupus La protein 1 195166000.0 82388000.0 53253000.0 59525000.0 True False 79772638.03691113 74517200.6107263 43933616.78827756 1.0 0.9341197990249097 0.5507354134126703 26.24939065204227 -6.936485718942506 0.6914896532250566 1.0046749838404405 0.45723038007346184 0.9976663163329889 0.009569448828162838 0.08940730676105142 0.06218986532319996 0.009083507269270609 0.03353978691490026 1.157482093355351e-07 6.936485718942506 -0.5474446037669787 IIEDQQESLNK(ub)WK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIEDQQESLNKWK 13 1 P05455 P05455 SSB Lupus La protein 1 310660000.0 99488000.0 112810000.0 98362000.0 True False 150930569.54705295 92678174.11144696 78920707.58640389 1.0 0.6140450830443221 0.5228941216033786 27.16930979867695 -13.99999999999999 0.20274103301010954 3.1682085677974188 0.46527001240508986 0.9994872521862251 0.004682783923747052 12.586402765390856 0.1427595995614415 10.834453337364968 0.05687578816633092 1.0000000000000246e-14 13.99999999999999 -2.702938555392329 IIEDQQESLNK(ub)WK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIEDQQESLNKWK 13 1 P05455 P05455 SSB Lupus La protein 1 187891000.0 63812000.0 45557000.0 78522000.0 True False 87405020.85445908 43544141.10314711 59976720.81135264 1.0 0.4981880980916859 0.6861930839330365 26.38121281983875 -10.09154064792546 5.1284125295158685 1.0000089434054065 0.5921905910114635 0.8625158587656683 0.076752714071541 7.848589215734124e-06 1.3903376367766566e-06 0.07431712453096775 0.02477183194749238 8.09952130414134e-11 10.09154064792546 -0.40781835239394293 IIEDQQESLNK(ub)WK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIEDQQESLNKWK 13 1 P05455 P05455 SSB Lupus La protein 1 182959000.0 82388000.0 70704000.0 29867000.0 True False 68509272.40724987 70323103.51835477 36112051.6105948 1.0 1.0264757024468554 0.5271118834240212 26.029795927476545 -6.894383515757894 0.9960736997256311 1.0240803512800671 0.4802811899899403 0.9835594287101475 0.02941599510737185 0.11565915008261224 0.20164071102984427 0.02236180043285247 0.056704960934680526 1.2753121117596422e-07 6.894383515757894 -0.5437991612901268 IIEDQQESLNK(ub)WK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIEDQQESLNKWK 13 1 P05455 P05455 SSB Lupus La protein 1 300994000.0 99488000.0 119360000.0 82146000.0 True False 128789177.20166753 112717511.0741275 67196270.88913797 1.0 0.8752094975933121 0.5217540196247789 26.940436120769398 -6.952735759439906 0.5279587270604833 1.00565748840124 0.3753165511381489 0.9993988412436506 0.0049661200657788295 0.08240549259311412 0.031557602466111105 0.0055572795385614585 0.029221339525931554 1.114972717212896e-07 6.952735759439906 -0.630340937263091 IIEGGAAHK(ub)DGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIEGGAAHKDGK 12 1 A0A590UJD9;A0A590UJ08;Q12959-2;Q12959-4;A0A0C4DFT3;A0A590UJR4;A0A590UJ18;A0A590UJ81;A0A590UJR5;A0A590UK48;Q12959;Q12959-3;Q12959-8;Q12959-9;A0A590UJC5;A0A590UJX2;A0A590UKA8;Q12959-6;A0A590UJS9;A0A590UJ68;A0A590UJ29;Q12959-5;A0A590UK81;Q12959-7;A0A590UJ64;A0A590UJZ4;A0A590UK52;A0A590UK02;B4E2H8;A0A590UK70;A0A590UJL2;H7C166;E7EQD7;A0A590UJ25 A0A590UJD9 DLG1 Disks large homolog 1 1 3351920.0 1294000.0 1631300.0 426620.0 True False 1252922.6782997893 2282686.597117117 314875.42367433774 1.0 1.8218894403082504 0.2513127339203584 20.2568659535965 -6.764519624899811 1.5955194533684105 1.4747163406977153 0.24427191564117462 0.7090988249325756 0.3459500897061697 0.27540095030897693 1.3827017324652524 0.17100091785589996 0.4091193228629586 1.719809624721985e-07 6.764519624899811 -1.2304444250565407 IIEK(ub)VIHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIEKVIHR 8 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 22581400.0 10293500.0 9046900.0 3241000.0 True False 9966738.476877032 12659374.348960256 2392084.8720841226 1.0 1.2701621877939484 0.24000678633574984 23.24869004254866 -6.83701982758819 1.2962011095434942 1.1438203547634749 0.2080826117291368 0.9191999144133727 0.12396835603437165 0.1723100438106395 0.5636547115497255 0.0750296607606224 0.17273680059840005 1.4553926335380086e-07 6.83701982758819 -0.9357377430343381 down IIEK(ub)VIHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIEKVIHR 8 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 41095600.0 22619700.0 13175000.0 5300900.0 True False 34315738.62157716 10823818.313255172 4253174.791532997 1.0 0.31541848574546894 0.1239423938512771 25.032367072199698 -12.526647729819006 0.2037209496740917 3.04582920630368 2.692538686289411e-21 0.9994086458166848 0.009144946987261308 6.7876778836207805 0.13401085626764944 5.789978890687547 0.11734496047245917 2.974077423196419e-13 12.526647729819006 -3.04582920630368 IIEK(ub)VIHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIEKVIHR 8 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 15909600.0 8046400.0 6276200.0 1587000.0 True False 11021371.525783867 5998896.731382044 1212183.2852909581 1.0 0.5442967526634929 0.10998479476489154 23.393800431707273 -7.840838044426228 0.43759888515984674 1.0389078490878756 4.232672030582164e-23 0.9969177525021633 0.020174247605860476 0.10959147701998924 0.08658741429187604 0.03511557669502495 0.07880571687479018 1.4426532404073668e-08 7.840838044426228 -1.0389078490878756 down IIEK(ub)VIHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIEKVIHR 8 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 28112900.0 10293500.0 16600300.0 1219100.0 True False 8559501.329368679 16510870.888998436 1474008.1735184675 1.0 1.9289524300145444 0.17220724862334771 23.029095317982936 -6.763027996853111 1.6009652655956375 1.5375519956503854 0.16478735300091818 0.7032388428089515 0.39090979418205746 0.2778639800438073 1.404280591371696 0.1925880989362005 0.4614662825549773 1.7257266392007057e-07 6.763027996853111 -1.372764642649467 IIEK(ub)VIHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIEKVIHR 8 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 53571700.0 22619700.0 27942500.0 3009500.0 True False 29281647.550946392 26387475.311568443 2461801.8800776745 1.0 0.9011608812536094 0.08407320236316786 24.803493394292147 -7.02695260691113 0.8381455160315862 1.0058008233987166 7.386399166684943e-26 0.9954886161338605 0.02756954111559451 0.07943852377395841 0.09495147666106708 0.024663416404266586 0.06077363322055596 9.398258649888087e-08 7.02695260691113 -1.0058008233987166 down IIENGENEK(ub)TVS ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIENGENEKTVS 12 1 H0YG54;H0YGR4;F5GYG5;Q9Y3B8-2;Q9Y3B8-3;Q9Y3B8 H0YG54 REXO2 Oligoribonuclease, mitochondrial 1 3430310.0 1035100.0 1658300.0 736910.0 True False 860731.512705059 1649366.4087532235 890994.4739131277 1.0 1.9162379724772556 1.0351595831700875 19.71520376351674 -6.637025906668221 2.054705153613345 1.6005208572464082 1.0387734446000232 0.14331992908392266 0.39232570113183546 0.5410430901328132 4.361628251921744 0.15567063542147963 0.4345707630687967 2.306609590030244e-07 6.637025906668221 -0.5617474126463851 IIENGENEK(ub)TVS ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIENGENEKTVS 12 1 H0YG54;H0YGR4;F5GYG5;Q9Y3B8-2;Q9Y3B8-3;Q9Y3B8 H0YG54 REXO2 Oligoribonuclease, mitochondrial 1 12030200.0 1448500.0 2339600.0 8242100.0 True False 1875111.8042036737 2209399.203326311 6742122.37108762 1.0 1.178275982463138 3.5955841971518483 20.838545188698735 -6.9217081897166395 0.8119691178727321 0.9498760611411231 4.001119788721459 0.9946421770017623 0.08665002075488402 0.09717702437197688 0.10048616291881596 0.0753411833023256 0.22949919139153593 1.1975449130306885e-07 6.9217081897166395 3.051243727580336 up IIETDFEK(ub)AHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIETDFEKAHR 11 1 K7EQS6;K7ENJ1;K7EJZ1;F5H385;Q9BRY0-2;Q9BRY0 K7EQS6 SLC39A3 Zinc transporter ZIP3 1 2859590.0 1026700.0 774190.0 1058700.0 True False 1346013.642576944 658683.8697689835 949155.8797675014 1.0 0.48935898488215374 0.7051606683200786 20.360261601841763 -10.267640215951593 5.628558491476958 1.000030401504152 0.5972598266011089 0.8228162542554388 0.0881006683427849 3.361293644979914e-05 4.373467616415483e-06 0.08530953163982884 0.02843436844010826 5.399577563119331e-11 10.267640215951593 -0.402770574903043 IIETLTQQLQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIETLTQQLQAK 12 0 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 0 15957600.0 1813400.0 8699300.0 5444900.0 False True 2377384.9609905817 7401398.349605802 4881513.97916885 1.0 3.113251943228358 2.0533123828354984 21.18094410169338 -9.166351049537473 11.63826746909405 1.0000225340792748 2.5832821630109586 0.7484303611872425 0.43271851372099995 0.0 0.0 0.41897789922088474 0.1396592997402949 6.817873680057727e-10 9.166351049537473 1.5832596289316838 IIETLTQQLQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIETLTQQLQAK 12 0 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 0 12253100.0 3321600.0 1920000.0 7011500.0 False True 3216157.626151919 2686666.012667727 5174977.809508738 1.0 0.8353651546246755 1.6090560261813152 21.61690668507451 -6.851079512033156 1.2298923887460536 0.9120586058642168 1.640631308785627 0.9418587560979175 0.08024030171919774 0.1562736401762051 0.45434493354097205 0.051037468539210686 0.1181864397582379 1.40903080490543e-07 6.851079512033156 0.7285727029214102 IIETLTQQLQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIETLTQQLQAK 12 0 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 0 13929100.0 1813400.0 4135300.0 7980400.0 False True 2483862.985292363 3952588.7723915973 6095593.881497148 1.0 1.5913070873055255 2.4540781506833667 21.244154163216272 -6.965712689337839 0.34560253006976793 0.9122898295011412 3.1620130427712994 0.9999270915819971 0.005098106870483247 0.07771994257335894 0.014011835155842528 0.011982010873817766 0.07437899892554142 1.082149618467682e-07 6.965712689337839 2.2497232132701583 IIEVHVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIEVHVEK 8 0 F5H170;Q8WW22;Q8WW22-2;Q8WW22-3 F5H170 DNAJA4 DnaJ homolog subfamily A member 4 0 16678100.0 7361100.0 4690900.0 4626100.0 False True 9650473.384993799 3991036.004984985 4147435.5486846487 1.0 0.41355857332251994 0.4297649849108737 23.20216828200876 -9.850829296357276 7.075875950153053 1.0000000042735868 0.4216617791166916 0.9994114059940652 0.006616239825518095 4.457609607423436e-10 6.745385661083742e-11 0.006406146664678012 0.0021353822215593476 1.4098428418810667e-10 9.850829296357276 -0.5783382251568951 IIEVHVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIEVHVEK 8 0 F5H170;Q8WW22;Q8WW22-2;Q8WW22-3 F5H170 DNAJA4 DnaJ homolog subfamily A member 4 0 11898200.0 5362400.0 2656800.0 3879000.0 False True 5192173.547229355 3717674.09502897 2862973.532494388 1.0 0.7160149908727133 0.5514017408031606 22.307907175223384 -11.464854917074462 0.08124481639022707 2.0905356171358767 2.5299173460469678e-08 0.9999376071690818 0.0014635639222411784 4.375162819749979 0.05500015096836685 1.239443210500912 0.3779967365922311 3.428823126635311e-12 11.464854917074462 -2.0905355918367032 IIEVHVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIEVHVEK 8 0 F5H170;Q8WW22;Q8WW22-2;Q8WW22-3 F5H170 DNAJA4 DnaJ homolog subfamily A member 4 0 19146900.0 7361100.0 4632900.0 7152900.0 False True 10082697.59624771 4428203.15904844 5463532.338599691 1.0 0.4391883339530486 0.5418720819945004 23.26537834353165 -10.13414178938486 5.610231782709662 1.0000070705461164 0.49053020797395064 0.9704339173606009 0.041920464596566065 3.70735258315713e-06 5.722069012732222e-07 0.04058987836665575 0.013529771770615996 7.342741016512576e-11 10.13414178938486 -0.5094768625721657 IIEVHVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIEVHVEK 8 0 F5H170;Q8WW22;Q8WW22-2;Q8WW22-3 F5H170 DNAJA4 DnaJ homolog subfamily A member 4 0 9338100.0 5362400.0 2493900.0 1481800.0 False True 4459073.194599172 2480464.8656996074 1791637.528930905 1.0 0.5562736374688682 0.4017959451979698 22.08831245065766 -13.999999999999995 0.1471410104229109 3.1367199792543072 0.22612368621913698 0.9995760611103973 0.005220607281981945 11.94815642547948 0.12065266692018146 7.306122038989789 0.15792337913887158 1.0000000000000123e-14 13.999999999999995 -2.9105962930351703 IIEVSGQK(ub)IK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIEVSGQKIK 10 1 P61106;X6RFL8 P61106 RAB14 Ras-related protein Rab-14 1 3509120.0 852810.0 1696100.0 960210.0 True False 709149.300888804 1686962.7726505087 1160985.4714905827 1.0 2.378854171520967 1.6371523881296577 19.43572987196663 -10.219541001609615 4.890720085909072 0.9998463772816933 2.0080032798269754 0.7112044556628423 0.3027984851092455 0.0005072804580552078 8.095183525066622e-05 0.29322715483581685 0.09772779083959283 6.031967576163595e-11 10.219541001609615 1.0081569025452821 IIFK(ub)AMGQGLPDEEQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIFKAMGQGLPDEEQEK 17 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 28637900.0 2963900.0 3881000.0 21793000.0 True False 2869812.616856833 5430703.5391476285 16084759.524013972 1.0 1.8923547507069 5.604811766989453 21.452525109166963 -6.943972681180253 0.6215059493296553 0.959407329341257 6.7349475760591195 0.9986393188149671 0.07355206257771678 0.08600008961830949 0.04670100360987904 0.0739710811327925 0.3143658352224308 1.1376988492753278e-07 6.943972681180253 5.7755402467178625 IIFK(ub)AMGQGLPDEEQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIFKAMGQGLPDEEQEK 17 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 19005000.0 2569400.0 4637600.0 11798000.0 True False 3519376.61542417 4432695.497507621 9011555.387437133 1.0 1.2595115504492187 2.560554431129282 21.746888477311078 -6.93974527965046 0.6619276607881632 0.9853305406263673 2.908792352046859 0.9981303635679845 0.02952184076003461 0.08788300245698018 0.05514001060362697 0.02868215700025185 0.11210439576628006 1.1488272286605074e-07 6.93974527965046 1.9234618114204916 up IIFK(ub)AMGQGLPDEEQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIFKAMGQGLPDEEQEK 17 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 20786200.0 2963900.0 5836300.0 11986000.0 True False 2464614.17303306 5804858.693485147 14492217.182997586 1.0 2.355280902382152 5.88011597984233 21.23293038460124 -6.954609116986013 0.5057217114632113 0.9327769059030894 7.456135945118145 0.9995150944828709 0.04529365996768822 0.0816861036459209 0.02869900009147657 0.05256316808325789 0.29083875153280814 1.1101735679091498e-07 6.954609116986013 6.523359039215056 IIFK(ub)AMGQGLPDEEQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIFKAMGQGLPDEEQEK 17 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 100088700.0 8180700.0 0.0 91908000.0 True False 10590077.415705223 0.0 75181687.05571647 1.0 0.0 7.099257550678624 23.336209799986147 -6.871225523899228 1.1275329201657367 0.4299639952010442 7.52493245640935 0.9658940580756951 0.579444188818514 0.13568829581150071 0.3216531584637023 0.3985118467522076 0.9455955436653684 1.3451616463977793e-07 6.871225523899228 7.094968461208306 up IIFK(ub)AMGQGLPDEEQEK(ub)LLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIFKAMGQGLPDEEQEKLLR 20 2 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 2 43806900.0 2926900.0 13271000.0 27609000.0 True False 4440321.285052159 10902686.363203727 22152069.04854543 1.0 2.455382316569387 4.988843740455871 22.08223263769728 -6.962666136863314 0.39607037691206803 0.8545504903594364 6.681597465510179 0.9998566619233564 0.01973223128966878 0.07876210808951907 0.017710313616655694 0.032625028771499476 0.21258215565006547 1.0897675283186134e-07 6.962666136863314 5.8270469751507425 IIFK(ub)AMGQGLPDEEQEK(ub)LLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIFKAMGQGLPDEEQEKLLR 20 2 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 2 33938900.0 2926900.0 10451000.0 20561000.0 True False 3788929.747824468 9869392.662832657 16819108.973675705 1.0 2.6047969531500224 4.4390131496454694 21.85335895978973 -6.969381119036141 0.2725608990236886 0.5579522694712712 6.541189629694383 0.9999771457999674 0.006716808240335297 0.07650403660025633 0.009746503732423513 0.03539961168032646 0.16999876489594334 1.0730473366783829e-07 6.969381119036141 5.983237360223112 IIFK(ub)LPNDSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIFKLPNDSR 10 1 Q96CS3 Q96CS3 FAF2 FAS-associated factor 2 1 8318100.0 2754000.0 2781900.0 2782200.0 True False 3610520.66977394 2366851.3637612686 2494324.6327468995 1.0 0.6555429480229124 0.6908490106783055 21.783775471127925 -9.798311983046077 6.330069227112814 1.0000000080819693 0.6731959796622825 0.9913223917046868 0.014413639722626078 1.6448635367540956e-09 3.121005807829388e-10 0.013955946962686998 0.004651982216915828 1.591065346763463e-10 9.798311983046077 -0.3268040284196868 IIFK(ub)LPNDSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIFKLPNDSR 10 1 Q96CS3 Q96CS3 FAF2 FAS-associated factor 2 1 19860800.0 2518100.0 10648000.0 6694700.0 True False 3820141.797768915 8747781.206796272 5371489.610608752 1.0 2.2899100792293248 1.4060969186394792 21.865194759192867 -10.129291860278315 5.1980722325264495 0.999974742400765 1.8480034989352496 0.5510614302554294 0.36081521190322696 251886975.63379604 0.8544020041549605 76148.05611967329 0.12351664415605028 7.425199721694587e-11 10.129291860278315 0.8480287565344846 IIFK(ub)LPNDSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIFKLPNDSR 10 1 Q96CS3 Q96CS3 FAF2 FAS-associated factor 2 1 10750900.0 2518100.0 4533500.0 3699300.0 True False 3259730.0891717477 4281206.739733217 3026065.358023375 1.0 1.3133623406289485 0.928317767190429 21.636321081285317 -6.690270513293767 1.8652960445918383 1.1964064540892287 0.9296383474855848 0.37176362237133354 0.13252264626583907 0.41608754319643587 2.8070188086850187 0.05682972222071166 0.1479467406336568 2.0404665831821366e-07 6.690270513293767 -0.2667681066036439 IIGATDSSGELMFLMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIGATDSSGELMFLMK 16 0 Q13185;P83916;J3KS05;B5MD17;K7ELA4 Q13185;P83916 CBX3;CBX1 Chromobox protein homolog 3;Chromobox protein homolog 1 0 12859200.0 8691600.0 0.0 4167600.0 False True 8415689.915541304 0.0 3075980.534679977 1.0 0.0 0.36550545059883277 23.004650117401113 -10.6073132460846 6.4500218113496866 1.0023961574574207 0.18275272529942962 0.8695519605879509 0.1492169753621974 0.005150111042744148 0.0003135459411711873 0.14471843633531098 0.048159571712436074 2.469941993081729e-11 10.6073132460846 -0.8196434321579911 IIGATDSSGELMFLMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 IIGATDSSGELMFLMK 16 0 Q13185;P83916;J3KS05;B5MD17;K7ELA4 Q13185;P83916 CBX3;CBX1 Chromobox protein homolog 3;Chromobox protein homolog 1 0 11490100.0 2948500.0 3405500.0 5136100.0 False True 4038640.1302164593 3255033.749517465 3923058.9612998753 1.0 0.8059727147174672 0.9713811666328416 21.945438167337766 -10.139294750810228 6.05084547864767 1.0000006895895648 0.8886769407015985 0.3765351794383276 0.06752771772273083 6.281508201113249e-07 8.93655459771951e-08 0.06538383586304358 0.021794477178960235 7.256133246295156e-11 10.139294750810228 -0.11132374888796626 IIGDAYLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIGDAYLK 8 0 A0A3B3ISJ5;A0A3B3ITR9;A0A3B3ISI3;A0A3B3ITL0;A0A3B3IRJ9;Q9Y2H2 A0A3B3ISJ5 INPP5F Phosphatidylinositide phosphatase SAC2 0 17012000.0 7911300.0 6442100.0 2658600.0 False True 7660160.111926679 9014464.125107702 1962232.9037096128 1.0 1.17679839499339 0.25616082105835686 22.86894311686194 -6.856939682868919 1.20099730277987 1.0952566032434985 0.21409395914056384 0.9498193583908505 0.08935888848879663 0.1499919396336835 0.4128394857061461 0.05809646418011139 0.13519010613372487 1.390145688644997e-07 6.856939682868919 -0.8811626441029347 down IIGDAYLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIGDAYLK 8 0 A0A3B3ISJ5;A0A3B3ITR9;A0A3B3ISI3;A0A3B3ITL0;A0A3B3IRJ9;Q9Y2H2 A0A3B3ISJ5 INPP5F Phosphatidylinositide phosphatase SAC2 0 13996170.0 881870.0 3219400.0 9894900.0 False True 1207921.1706406625 3077156.2628678707 7557928.411862324 1.0 2.5474810257988896 6.256971560365745 20.20409487627472 -6.9563558550214415 0.48406704105245296 0.914281775506039 8.045896766236659 0.9996102592461535 0.04354696883416303 0.08102950054740801 0.026143538214403447 0.052741857016350376 0.3059666883116984 1.1057174028132503e-07 6.9563558550214415 7.13161499073062 IIGDAYLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIGDAYLK 8 0 A0A3B3ISJ5;A0A3B3ITR9;A0A3B3ISI3;A0A3B3ITL0;A0A3B3IRJ9;Q9Y2H2 A0A3B3ISJ5 INPP5F Phosphatidylinositide phosphatase SAC2 0 12760700.0 7911300.0 2668100.0 2181300.0 False True 6578596.480015002 2653726.415723614 2637399.7448083316 1.0 0.4033879299004462 0.40090614355515497 22.649348392296215 IIGHFFASQTAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIGHFFASQTAQR 13 0 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 0 49078000.0 15846000.0 18235000.0 14997000.0 False True 21704694.422048517 17429317.404918797 11455017.47291023 1.0 0.8030206307449039 0.5277668162549091 24.3715037754041 -6.966408180175051 0.3329997076105425 1.0323831358776219 0.289352924369975 0.9999392986618694 0.0015088860268598265 0.07748630836539927 0.01319243999664055 0.003974589519230592 0.023951093928497407 1.0804180219128408e-07 6.966408180175051 -0.7430302115076468 IIGLDQVAGMSETALPGAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIGLDQVAGMSETALPGAFK 20 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 2924700.0 633830.0 1917600.0 373270.0 False True 830957.2680184515 1631501.5547462539 334647.6010586706 1.0 1.963400065850349 0.40272540350563457 19.6644147627405 -6.739684325275685 1.6876355090194723 1.5734107899307954 0.4018303145374897 0.6036538098566091 0.40478231644929197 0.31836927648452235 1.7802539990945243 0.18974800184048446 0.46582496715849797 1.8210240216020967e-07 6.739684325275685 -1.1715804753933057 IIGLDQVAGMSETALPGAFK ddPTM_RPMI8226_Bortezomib_2h_R1 2 IIGLDQVAGMSETALPGAFK 20 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 25533670.0 10723800.0 5609270.0 9200600.0 False True 10383378.838911342 7849080.762956627 6790686.84791645 1.0 0.7559274186878819 0.6539958671707704 23.30777264942292 -13.999999999910676 0.11970353250314757 2.1635455854277224 0.49065520496882453 0.9996943966993179 0.0025378607311310445 11.964877510663754 0.10644067144043408 3.3131546006873815 0.1449434645821588 1.0000000002056764e-14 13.999999999910676 -1.672890380458898 IIGLDQVAGMSETALPGAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIGLDQVAGMSETALPGAFK 20 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 6720730.0 633830.0 1515200.0 4571700.0 False True 868174.0796117007 1448253.453903647 3491958.6171169966 1.0 1.6681602087813914 4.022187138642527 19.72762482426339 -6.94779284163121 0.5825710422534022 0.9721239497352275 4.835172770291055 0.9990165003397714 0.04065025055453773 0.08438431746373264 0.039724973269067564 0.042473295633945495 0.19678505951616923 1.1277352573602773e-07 6.94779284163121 3.8630488205558273 IIGLDQVAGMSETALPGAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIGLDQVAGMSETALPGAFK 20 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 13637200.0 8932300.0 2490900.0 2214000.0 False True 7427603.217984143 2477481.02729506 2676937.1636206163 1.0 0.3335505350227163 0.3604038994892809 22.8244653179933 -10.575699411231945 6.379110395272758 1.0012831222523333 0.34697721725600306 0.9987333644048226 0.010962840136678047 0.00020037831919395322 1.3327942741871128e-05 0.010631790209702292 0.0035382414397073588 2.6564435333376374e-11 10.575699411231945 -0.6543059049963302 IIGLDQVAGMSETALPGAFK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIGLDQVAGMSETALPGAFKTR 22 1 P35579;P35579-2 P35579 MYH9 Myosin-9 1 9353000.0 3340900.0 2173400.0 3838700.0 True False 3234844.9582161997 3041249.954131268 2833229.311468475 1.0 0.940153235599988 0.8758470183469972 21.625265136759012 -6.970209747410402 0.25312765973191026 1.019638414584936 0.7944708620066203 0.9999839594271508 0.0002029594083847084 0.07623469771056905 0.008786359701727196 0.0014044025443841425 0.006132138571609775 1.0710019278699842e-07 6.970209747410402 -0.22516755257831567 IIGLDQVAGMSETALPGAFK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIGLDQVAGMSETALPGAFKTR 22 1 P35579;P35579-2 P35579 MYH9 Myosin-9 1 10700900.0 3340900.0 3040300.0 4319700.0 True False 2778106.376964861 3023921.300447698 5222929.297963849 1.0 1.08848290530595 1.8800321475342525 21.405670412193288 -6.92807772214885 0.7623986256688012 0.987066402240323 2.03485839735657 0.9961470145012787 0.024558828262021767 0.09364774911123482 0.0826581574208781 0.022123811406313316 0.072392995527649 1.1801094221739404e-07 6.92807772214885 1.047791995116247 IIGNLLYYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIGNLLYYR 9 0 P46940;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 20008100.0 4527100.0 11521000.0 3960000.0 False True 5935071.940498769 9802111.708506254 3550257.1870022686 1.0 1.6515573537736272 0.5981826711781886 22.500834086566552 -6.739405705970276 1.6891135495436003 1.387940241565964 0.5976720533752595 0.6022037408017373 0.27375908405705424 0.31887463821065914 1.786180475449491 0.12823451785962417 0.3148521489184695 1.822192664665808e-07 6.739405705970276 -0.7902681881907045 IIGNLLYYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIGNLLYYR 9 0 P46940;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 17589000.0 8659600.0 3789300.0 5140100.0 False True 13137246.301560592 3113069.8090639664 4124156.982014138 1.0 0.23696517044779472 0.313928572803284 23.647159568226623 -10.381928296487148 5.884510109887522 1.0001671171605084 0.2754468716989627 0.9916086922654641 0.03142017743991381 6.890324032878542e-05 7.237152681550519e-06 0.030429315422367157 0.01014081866330526 4.150225586301219e-11 10.381928296487148 -0.7247202454615458 IIGNLLYYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIGNLLYYR 9 0 P46940;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 10985900.0 4253100.0 2980100.0 3752700.0 False True 3536641.0942767663 2964045.609796466 4537372.219475645 1.0 0.8380962418247886 1.282960893831814 21.75394838808609 -6.808212924600995 1.4218845938107132 0.9115752405103024 1.2904405266888257 0.8551493529959707 0.06996926753334803 0.20924552828003204 0.8340889615665897 0.03869566103310055 0.08959179357904987 1.5552029643985285e-07 6.808212924600995 0.37886528617852333 IIGNLLYYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIGNLLYYR 9 0 P46940;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 34154600.0 8659600.0 15020000.0 10475000.0 False True 11210022.906235531 14184123.796358882 8568657.482576383 1.0 1.2653072982098028 0.7643746631249166 23.418285890319073 -6.762790571049413 1.6017806027681174 1.1535666150731911 0.762275107420226 0.7023443402750613 0.11163869641178348 0.27824439128195716 1.4075742987645021 0.054973237110245175 0.13175769876061058 1.7266703400088156e-07 6.762790571049413 -0.39129150765296516 IIGVK(ub)VHPGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIGVKVHPGQR 11 1 Q9BSJ8-2;Q9BSJ8;F8VZB1 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 4539500.0 1710900.0 1539200.0 1289400.0 True False 2243006.468379169 1309557.3597546085 1155985.2567981638 1.0 0.5838402065335616 0.5153731266916483 21.097002350196462 -13.999999999999998 0.25395865291757563 3.952935569369708 0.4888619769330505 0.9995502692510585 0.0045414331309743495 14.158502662099004 0.15946290550807213 21.378865673456925 0.030916806305626956 1.0000000000000041e-14 13.999999999999998 -3.4640735924366575 IIGVK(ub)VHPGQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIGVKVHPGQR 11 1 Q9BSJ8-2;Q9BSJ8;F8VZB1 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 12499700.0 3407600.0 4722800.0 4369300.0 True False 5169578.328929495 3879979.440595175 3505705.9398677824 1.0 0.7505407972798108 0.6781415652896657 22.301615177219855 -13.999999999999998 0.17345777659725542 2.2698226393303194 0.6165725387043476 0.9995075063374877 0.0030595538958419367 12.127068034601132 0.13194862507833874 5.183595063910233 0.0572185307919397 1.0000000000000041e-14 13.999999999999998 -1.6532501006259719 IIGVK(ub)VHPGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIGVKVHPGQR 11 1 Q9BSJ8-2;Q9BSJ8;F8VZB1 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 4677300.0 1710900.0 1024500.0 1941900.0 True False 2343465.965334015 979234.2024315504 1483263.214685896 1.0 0.41785723237161665 0.6329356758865862 21.160212411719353 -10.14995868491043 5.290311884160426 1.0000151128825545 0.5253964541288726 0.8665318587183906 0.08780540688143389 1.565190252977131e-05 2.5148033953620115e-06 0.08501992400334092 0.0283390732131118 7.080131355387081e-11 10.14995868491043 -0.4746186587536819 IIGVK(ub)VHPGQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIGVKVHPGQR 11 1 Q9BSJ8-2;Q9BSJ8;F8VZB1 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 4554000.0 0.0 2971400.0 1582600.0 True False 0.0 2955392.478423278 1913514.3428843643 0.0 IIGVK(ub)VHPGQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIGVKVHPGQR 11 1 Q9BSJ8-2;Q9BSJ8;F8VZB1 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 9325100.0 3407600.0 4477900.0 1439600.0 True False 4411205.373838074 4228700.928609547 1177607.571543385 1.0 0.9586270804096038 0.26695822836259825 22.072741499312304 -6.919158102742038 0.8309623495061625 1.015729779313838 0.1575577760023705 0.9939434216502898 0.02616692759628575 0.09866992581971398 0.10820530015889442 0.022445436117371372 0.06670151429182573 1.2045973328837037e-07 6.919158102742038 -0.8581720033114675 down IIIDK(ub)EYYYTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIIDKEYYYTK 11 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 60862500.0 17453800.0 43408700.0 0.0 True False 22882100.822839618 36932291.16578732 0.0 1.0 1.6140253664525241 0.0 24.447716177322423 -6.8191126522075045 1.4794049991002713 1.3362417985080008 1.136636030754619e-18 0.841936140712479 0.26445476184054106 0.20674848855102557 0.906048208513738 0.1426787041427177 0.31363729978464955 1.5166569088340014e-07 6.8191126522075045 -1.3362417985080008 IIIDK(ub)EYYYTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIIDKEYYYTK 11 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 105742500.0 32667800.0 35893700.0 37181000.0 True False 31630778.57044963 50226241.59317272 27442180.69390923 1.0 1.587891410301721 0.8675784136261032 24.91482573147698 -6.68973773137559 1.8674703643025008 1.3686684401525404 0.870085994488826 0.3691101794761028 0.2486511304172762 0.4172510988261627 2.8210904753853128 0.10652809864733392 0.2774857740965749 2.042971314065739e-07 6.68973773137559 -0.49858244566371446 IIIDK(ub)EYYYTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIIDKEYYYTK 11 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 38397600.0 17453800.0 20943800.0 0.0 True False 23906941.53120977 20018433.66411509 0.0 1.0 0.8373481667649392 0.0 24.510926238845315 -7.195536947540042 0.8963257767433082 0.9909923148962557 1.1662183976474548e-19 0.9893878379522548 0.04513393796257604 0.09233600578280733 0.1409957611903899 0.03800776036608368 0.0667230997816269 6.374748456478953e-08 7.195536947540042 -0.9909923148962557 down IIIDK(ub)EYYYTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIIDKEYYYTK 11 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 99064800.0 32667800.0 45974000.0 20423000.0 True False 27164723.12892116 45726328.936875544 24693354.874717183 1.0 1.6832981775614937 0.9090228807974556 24.695231006911257 -6.67377860714649 1.9244595790465227 1.43473682621252 0.9121297050039944 0.29568196666578506 0.2900025505668145 0.4524992553214698 3.2345241615793006 0.12117582541662825 0.32210808561867543 2.119441299966822e-07 6.67377860714649 -0.5226071212085256 IIIDK(ub)EYYYTKEEQFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIIDKEYYYTKEEQFK 16 2 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 62356900.0 9839900.0 32283000.0 20234000.0 True False 14927847.693048863 26521846.42176977 16234741.031122763 1.0 1.776669146625849 1.0875473387019117 23.831502835953017 -10.177267678230848 4.358776505843003 0.9998964006406115 1.4321082426756524 0.34393621866863733 0.28133280010585954 197330107.44424525 46.98222020261178 221948.16729545235 0.09630770047480146 6.648632401644319e-11 10.177267678230848 0.4322118420350409 IIIDK(ub)EYYYTKEEQFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIIDKEYYYTKEEQFK 16 2 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 61915300.0 9839900.0 33797400.0 18278000.0 True False 12737944.523426821 31916544.979697675 14951591.548117539 1.0 2.5056275697384915 1.173783691758079 23.602629158045467 -6.6166719747882885 2.1292642478531274 2.0013720020275 1.1788009778461805 0.07159391363910428 0.6480286290711017 0.5944381466815881 5.116531043923022 0.2504971334712114 0.7186914414314922 2.4172859355837747e-07 6.6166719747882885 -0.8225710241813193 IIIENLFYPVTLEVLHQIFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIIENLFYPVTLEVLHQIFSK 21 0 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2 O95758-1 PTBP3 Polypyrimidine tract-binding protein 3 0 328652000.0 116640000.0 136410000.0 75602000.0 False True 176951407.52621672 112066569.72380543 60659231.56246628 1.0 0.6333183289723304 0.3428016335698214 27.398777996550184 -7.702279027044645 0.22376087433573472 1.1823842135082796 1.1285812325812698e-14 0.9998580137343843 0.00320415364294968 0.1297161230410808 0.02882479152258076 0.044529368520680214 0.08126747670110931 1.984819293944028e-08 7.702279027044645 -1.1823842135082683 down IIIK(ub)EHPVIESHPDNALEDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIIKEHPVIESHPDNALEDLR 21 1 Q13564;Q13564-4;Q13564-3;Q13564-2;H3BMR3;J3QRA5 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 1 62514000.0 15722000.0 14897000.0 31895000.0 True False 15222913.715787716 20845449.786828723 23540742.67051006 1.0 1.3693469053306044 1.5464018984812289 23.859741186062198 -11.567706866743004 0.12600265373694727 6.474770563255227e-16 1.8491452708419298 0.9997472719794867 0.0036186552564832124 4.490073118200267 0.08331407323290492 1.452460978936121 0.21991581964449233 2.70578405545519e-12 11.567706866743004 1.8491452708419291 IIIK(ub)EHPVIESHPDNALEDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIIKEHPVIESHPDNALEDLR 21 1 Q13564;Q13564-4;Q13564-3;Q13564-2;H3BMR3;J3QRA5 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 1 70256000.0 23934000.0 23401000.0 22921000.0 True False 36309627.80977773 19224908.7171525 18390654.30336881 1.0 0.5294713792680483 0.5064952579441323 25.113848806144205 IIIK(ub)EHPVIESHPDNALEDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIIKEHPVIESHPDNALEDLR 21 1 Q13564;Q13564-4;Q13564-3;Q13564-2;H3BMR3;J3QRA5 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 1 47945000.0 15722000.0 21040000.0 11183000.0 True False 13073539.602694372 20926653.343886998 13521313.5956501 1.0 1.6006876469456022 1.0342504024589825 23.640146461496474 -10.267495498181969 4.983076223117005 0.9999289481170862 1.31746902470248 0.2951939596041989 0.23124703671737473 0.0001825777556534503 2.6838601617033013e-05 0.22395394011199643 0.07463466017209076 5.4013771370544e-11 10.267495498181969 0.31754007658539385 IIIK(ub)EHPVIESHPDNALEDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIIKEHPVIESHPDNALEDLR 21 1 Q13564;Q13564-4;Q13564-3;Q13564-2;H3BMR3;J3QRA5 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 1 68102000.0 23934000.0 16560000.0 27608000.0 True False 30983034.809672642 15638421.442590073 22583627.282001812 1.0 0.5047414347450525 0.728903008395788 24.884975128236654 -10.336459701605452 5.8312701325419125 1.0000517747000324 0.6168222215704198 0.7957509167369214 0.09151357923060582 6.160642140441486e-05 7.010257611014595e-06 0.08861957013758161 0.029535880692663583 4.608295273006596e-11 10.336459701605452 -0.3832295531296126 IIINPSSSLLASQDETK(ub)LPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIINPSSSLLASQDETKLPK 20 1 Q9NWF9;Q9NWF9-1 Q9NWF9 RNF216 E3 ubiquitin-protein ligase RNF216 1 48556600.0 1296600.0 14846000.0 32414000.0 True False 1967036.9941571713 12196615.307672566 26007358.69243908 1.0 6.200501233022577 13.221591037530342 20.907592660029184 -6.966948012935768 0.3228763264811157 0.0703472149989048 19.579169355656777 0.9999478525674342 0.03616336847473733 0.07730600446617442 0.012561344039132304 0.10521384014043487 0.6160421605196009 1.0790758848883824e-07 6.966948012935768 19.508822140657873 IIINPSSSLLASQDETK(ub)LPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIINPSSSLLASQDETKLPK 20 1 Q9NWF9;Q9NWF9-1 Q9NWF9 RNF216 E3 ubiquitin-protein ligase RNF216 1 58205300.0 1296600.0 7249700.0 49659000.0 True False 1678474.2598070316 6846247.822001528 40621571.54436859 1.0 4.07885183940123 24.20148614554191 20.678718982121634 -6.934052999960157 0.712738809079588 0.7351626363006912 28.793971495735104 0.9972765779020177 0.5369282928191131 0.09058726471748989 0.06776634970756795 0.5015474510445812 1.781920212397939 1.163983971725799e-07 6.934052999960157 28.05880885943441 IIK(ub)VGGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIKVGGER 8 1 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 1 2414060.0 714800.0 911340.0 787920.0 True False 937109.7221330472 775371.6243754969 706393.596662331 1.0 0.8274075127623237 0.7538003074543282 19.83785845114709 -13.99999999988766 0.11641705563966841 1.8252816750386351 0.630439920202158 0.9997106859909219 0.0017550532163804803 11.978916489522275 0.10452765560838984 2.2988176619976706 0.10946513794706063 1.0000000002586732e-14 13.99999999988766 -1.1948417548364771 IIK(ub)VGGER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIKVGGER 8 1 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 1 3472200.0 689000.0 1180600.0 1602600.0 True False 667128.072139533 1652019.7367476663 1182830.983030551 1.0 2.476315726678248 1.7730193532961636 19.347604224308284 -10.682878285963827 7.056689160143491 0.993495786353216 2.1246675399872057 0.7732248346512748 0.2871195421226706 0.029223489330922427 0.001313278179036073 0.2765158562971735 0.09266743375098352 2.0754951078311322e-11 10.682878285963827 1.1311717536339896 IIK(ub)VGGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIKVGGER 8 1 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 1 16011800.0 1417300.0 2406500.0 12188000.0 True False 2150147.7185091474 1977041.2729296791 9779036.45780984 1.0 0.9194909056297326 4.548076568706801 21.036004347948136 -6.901826866056805 0.9496461047358844 0.8566054635758366 4.943410563468304 0.9874534914739511 0.1895089231860055 0.11007303516461202 0.16993270046876113 0.14913916864263663 0.39171513532397567 1.2536408463261674e-07 6.901826866056805 4.086805099892468 up IIK(ub)VGGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIKVGGER 8 1 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 1 2861150.0 714800.0 608250.0 1538100.0 True False 979080.8767436754 581375.5037862282 1174832.458163846 1.0 0.5937972210424789 1.1999340259521978 19.90106851266998 -6.72612502077227 1.7373200825052788 0.754498057011161 1.1993274648654555 0.5412022949685429 0.17081661988387337 0.3435642415230971 2.029663298397803 0.07797402639256927 0.1943447525546014 1.8787758939165072e-07 6.72612502077227 0.4448294078542945 IIK(ub)VGGER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIKVGGER 8 1 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 1 3815500.0 689000.0 1481500.0 1645000.0 True False 572934.0278753608 1473518.8654452756 1988961.894379364 1.0 2.5718822652402014 3.4715373805866068 19.12800949974256 -8.72911951207891 0.2253910381577813 3.427744763247608e-17 4.281185193637483 0.999455295284888 0.023837560287375208 0.28477706811429576 0.06709778886485425 0.6182342195563529 0.40639356229776114 1.865866158570001e-09 8.72911951207891 4.281185193637483 IIK(ub)VGGER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIKVGGER 8 1 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 1 11912100.0 1417300.0 1853000.0 8641800.0 True False 1834722.7891597312 1749878.9210820897 7069081.072355959 1.0 0.9537565737020695 3.8529423159307163 20.807130670040586 -6.903276083142501 0.9403175064829886 0.8900562679426441 4.17835331907952 0.9881270766205876 0.14774514725014462 0.10903405433664716 0.1641288764549985 0.11707582044335457 0.309938890750615 1.2494644869647858e-07 6.903276083142501 3.2882970511368756 up IIKPCNHVLSLSFPIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIKPCNHVLSLSFPIR 16 1 P00367;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 70920300.0 28632500.0 31037000.0 11250800.0 False True 37537484.77752444 26406400.58127842 10086675.141294224 1.0 0.7034675002276457 0.26870940344233235 25.161828648941828 -7.142318825736718 0.38384522081701006 1.032517371281966 9.688302176996757e-17 0.9998158645324268 0.004075241819340414 0.08096057104233473 0.020361953970766823 0.007412611015163824 0.03900261764673116 7.205782915849791e-08 7.142318825736718 -1.032517371281966 down IIKPCNHVLSLSFPIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIKPCNHVLSLSFPIR 16 1 P00367;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 76571900.0 36149700.0 22936300.0 17485900.0 False True 35002147.560845315 32094884.201224394 12905818.224244313 1.0 0.9169404290246153 0.3687150396074907 25.0609401057072 -6.933852014413647 0.7144677210843903 1.0072643477167653 0.24426899156351076 0.9972425949340925 0.01470694018270202 0.09068653278191398 0.06823995169178429 0.013720133700998317 0.04859719864850236 1.164522772253596e-07 6.933852014413647 -0.7629953561532545 down IIKPCNHVLSLSFPIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIKPCNHVLSLSFPIR 16 1 P00367;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 140033100.0 37471100.0 34657000.0 67905000.0 False True 56846398.204351984 28472187.573623072 54483546.98618115 1.0 0.5008617691356799 0.9584344603561894 25.76056560686758 -10.47335113975274 8.982773437929021 1.0000050253001866 0.7296481147459347 0.3176179014632854 0.18680326895372207 1.880029633566955e-05 1.1020894398744916e-06 0.1808748464153281 0.060290495806239165 3.362395999213334e-11 10.47335113975274 -0.27035691055425193 IIKPCNHVLSLSFPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIKPCNHVLSLSFPIR 16 1 P00367;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 123066600.0 28632500.0 32517100.0 61917000.0 False True 39218709.01421836 31080387.00232989 47293479.82064296 1.0 0.7924887836328829 1.2058907855303747 25.22503871046472 -6.770215600153967 1.5735090354545749 0.8810117916753334 1.2082421350723198 0.7314445701006487 0.08746111919213483 0.2660718221523487 1.3001259513874381 0.043810594050486 0.1042718473134269 1.6974007895196874e-07 6.770215600153967 0.3272303433969864 IIKPCNHVLSLSFPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIKPCNHVLSLSFPIR 16 1 P00367;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 78075700.0 36149700.0 10240400.0 31685600.0 False True 30060077.253245115 10185232.93263974 38310912.462338455 1.0 0.3388292334325322 1.274478177137839 24.841345381141476 -6.716866744080028 1.7707400401283302 0.5964106373546287 1.2727554528744334 0.49764313275384897 0.2783349603814066 0.361430919554852 2.213073968772509 0.12489585961408081 0.3146788575059674 1.9192575420652966e-07 6.716866744080028 0.6763448155198046 IIKPCNHVLSLSFPIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIKPCNHVLSLSFPIR 16 1 P00367;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 170020100.0 37471100.0 78715000.0 53834000.0 False True 48507077.61580693 74334441.05395387 44036764.383486144 1.0 1.5324452576324783 0.9078420417794031 25.53169192896003 -6.680912715102395 1.8984786025996683 1.336604644953305 0.910192905488579 0.32837452594491934 0.22561750209834208 0.43650192797882326 3.042462576092084 0.09532823383343232 0.2511434852674034 2.0849098680620737e-07 6.680912715102395 -0.4264117394647261 IIKPVLTQESATYIAEEYSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIKPVLTQESATYIAEEYSR 20 1 P25205;P25205-2;J3KQ69;A0A499FHX9;Q7Z6P5 P25205 MCM3 DNA replication licensing factor MCM3 0 18034400.0 3379800.0 3055600.0 11599000.0 False True 3272510.099008982 4275717.014743494 8560873.937458744 1.0 1.306555789098501 2.615996185940341 21.641966213677332 -6.943368722303658 0.627440024826897 0.9857136095461538 3.007101203732835 0.9985726959956702 0.026475902818144808 0.0862628336534559 0.047859397879400224 0.026485129307165598 0.11113737099951056 1.1392821098252065e-07 6.943368722303658 2.021387594186681 up IIKPVLTQESATYIAEEYSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIKPVLTQESATYIAEEYSR 20 1 P25205;P25205-2;J3KQ69;A0A499FHX9;Q7Z6P5 P25205 MCM3 DNA replication licensing factor MCM3 0 8814200.0 3379800.0 1700800.0 3733600.0 False True 2810453.450527054 1691637.452817634 4514278.497784069 1.0 0.6019090807216165 1.6062456031561352 21.422371489111608 -6.799172386631067 1.4593937100549057 0.7801230868106515 1.619811107464239 0.8296972134062195 0.17041257791727246 0.22194550331090243 0.9333390116373184 0.091867716360265 0.21374912163671653 1.587916324100762e-07 6.799172386631067 0.8396880206535875 IILDLISESPIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IILDLISESPIK 12 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 108383000.0 14996000.0 45181000.0 48206000.0 False True 19659901.22147056 38440170.91415866 43218105.54460393 1.0 1.9552575814662883 2.1982870136400012 24.22875273728105 -10.614622358910438 0.2826064576073508 2.7434086110901574e-13 2.2887562488040243 0.9991231324401372 0.015315329657311838 2.264715444096762 0.14006306930816467 1.6721445383705282 0.09411021277393654 2.428721073362714e-11 10.614622358910438 2.28875624880375 IILDLISESPIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IILDLISESPIK 12 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 126859000.0 52218000.0 40924000.0 33717000.0 False True 50560368.17268808 57265166.615840726 24885506.211681694 1.0 1.1326097630510228 0.49219392799288303 25.5915036332443 -6.8526892347707715 1.2218897122596133 1.0709710899153075 0.4652122346985588 0.9441393583929165 0.06523224015339874 0.15453204888721384 0.4426058628299033 0.04174121174185181 0.09678171202088791 1.403817865911556e-07 6.8526892347707715 -0.6057588552167488 down IILDLISESPIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IILDLISESPIK 12 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 123905000.0 12821000.0 93353000.0 17731000.0 False True 19450394.34065179 76693427.77968189 14226460.078226622 1.0 3.9430268834905204 0.7314227068647641 24.213296069167765 -6.665644082089444 1.952650377397 2.8854247699409923 0.7445236832315529 0.26009627191980367 1.2513833937804537 0.47110667205741863 3.458626270820515 0.5166927472188075 1.3884453424525618 2.1595134729823576e-07 6.665644082089444 -2.140901086709439 IILDLISESPIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IILDLISESPIK 12 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 145674000.0 14996000.0 58785000.0 71893000.0 False True 20540426.451662198 56187684.32400065 54913354.08281217 1.0 2.7354682463008824 2.6734281399677755 24.29196279880394 -10.130680223708673 5.2639888831311215 0.9999547639141695 2.7044481931355375 0.9990073242453655 0.025327767354920126 1.3446825500584722e-05 2.2206704904359802e-06 0.024524148561375515 0.008174501762908154 7.401500559271563e-11 10.130680223708673 1.704493429221368 IILDLISESPIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IILDLISESPIK 12 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 87574000.0 52218000.0 14642000.0 20714000.0 False True 43421580.649630696 14563120.639790546 25045201.629285183 1.0 0.33538900293152746 0.5767915689522047 25.371908908678577 -10.229736112603685 5.493001565212164 1.00003194964788 0.4560902859419225 0.8712791961860151 0.09855218489165679 3.856303850911085e-05 5.407409996655667e-06 0.09542833215085059 0.03180758090146022 5.892015591372194e-11 10.229736112603685 -0.5439416637059575 IILDLISESPIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IILDLISESPIK 12 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 48510000.0 12821000.0 20957000.0 14732000.0 False True 16597037.239693021 19790724.527316447 12050927.163085002 1.0 1.1924251444098402 0.7260890596946022 23.984422391260214 -6.794620486944873 1.4775720036588162 1.106900810412637 0.7204592584386494 0.8160505183951068 0.08206756407896122 0.22851214489585028 0.985363767815987 0.043705443651483045 0.10200283804834484 1.6046470168001375e-07 6.794620486944873 -0.38644155197398755 IILDLISESPIK(ub)GR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IILDLISESPIKGR 14 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 118866200.0 26127300.0 46625000.0 46113900.0 True False 34253143.317133136 39668731.742826514 41342475.983763635 1.0 1.1581048599117776 1.2069688203793103 25.029733050531657 -13.99999999999963 0.16443761958538072 0.21361014899582623 1.2527277826257912 0.9995254021062937 0.0019243008456640961 12.04223873608627 0.1282830897737502 3.019859115612797 0.04195002844542989 1.0000000000008507e-14 13.99999999999963 1.039117633629965 IILDLISESPIK(ub)GR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IILDLISESPIKGR 14 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 209406200.0 46824200.0 79688100.0 82893900.0 True False 45337791.401271224 111507973.89795154 61181500.82630493 1.0 2.459492852464467 1.3494592245309387 25.43421077712433 -10.364634740652566 5.455582170914312 0.9996908926432819 1.904476038497713 0.4695633088474599 0.4531693309613091 0.0017043347979330198 0.00019848802047021672 0.4389225618979667 0.14625977265208553 4.31882154606691e-11 10.364634740652566 0.9047851458544311 IILDLISESPIK(ub)GR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IILDLISESPIKGR 14 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 582644100.0 77526300.0 172565800.0 332552000.0 True False 117613065.0317191 141770084.7272508 266822951.4372805 1.0 1.2053940154439202 2.2686506075266464 26.809473089762292 -6.939034580178052 0.6684940796353724 0.9878429764718033 2.547404506206963 0.9980345755191724 0.024648993275645285 0.08821001137385204 0.05663815432514739 0.023821826842612078 0.09190857844047125 1.1507087614894668e-07 6.939034580178052 1.5595615297351595 up IILDLISESPIK(ub)GR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IILDLISESPIKGR 14 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 112876800.0 26127300.0 45090000.0 41659500.0 True False 35787268.87373396 43097774.70730956 31820384.104334414 1.0 1.204276718052132 0.8891537439362679 25.09294311205455 -6.731729319212063 1.7168628340670737 1.1226980147182906 0.8892803220313921 0.5672324047211355 0.0858624334462948 0.33303605249782725 1.9239316560659918 0.03961859321094302 0.09812129511435633 1.8546872259026508e-07 6.731729319212063 -0.2334176926868985 IILDLISESPIK(ub)GR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IILDLISESPIKGR 14 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 138375900.0 46824200.0 47325100.0 44226600.0 True False 38936396.96377566 47070150.29300315 53474177.579305954 1.0 1.208898459115123 1.3733725190097963 25.214616052558608 -6.9738140640420605 0.13971344371522956 0.7788010696176647 1.8077589584058193 0.9999989327880776 0.00015773337759479085 0.07508348141821138 0.004229922644873247 0.009324509301729945 0.021447673043333487 1.0621502018075554e-07 6.9738140640420605 1.0289578887881548 IILDLISESPIK(ub)GR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IILDLISESPIKGR 14 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 415625300.0 77526300.0 85673000.0 252426000.0 True False 100359323.62184002 80905222.23738046 206487058.1094826 1.0 0.8061555151790004 2.057477578142498 26.58059941185474 -6.867339463478623 1.1480111281616867 0.8919389044539746 2.127169184514518 0.9619584768021773 0.10725638279059534 0.13943495004014983 0.345112012622675 0.07261577879887601 0.17117851177583246 1.3572521444828778e-07 6.867339463478623 1.2352302800605437 up IILEAEK(ub)MDGAASQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IILEAEKMDGAASQGK 16 1 Q15382;C9J931 Q15382 RHEB GTP-binding protein Rheb 1 5642000.0 0.0 3581500.0 2060500.0 True False 0.0 3423257.4875633004 1573852.3373295672 0.0 IILEAEK(ub)MDGAASQGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IILEAEKMDGAASQGK 16 1 Q15382;C9J931 Q15382 RHEB GTP-binding protein Rheb 1 18173800.0 7824000.0 3267600.0 7082200.0 True False 10128322.234097047 3085755.1875487487 5793312.269508593 1.0 0.3046659768742881 0.5719913067146875 23.271891874380568 -10.346508177305173 5.81071789582953 1.0000895830096868 0.43832864179482434 0.854778613532492 0.10913510890503668 0.00012667492246809249 1.4246253235528742e-05 0.10568631691263668 0.035223204939644225 4.502895027337916e-11 10.346508177305173 -0.5617609412148624 IILGGFSQGGALSLYTALTTQQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IILGGFSQGGALSLYTALTTQQK 23 0 O75608;O75608-2;A0A087X1K9;E5RGR0;E5RJ48 O75608 LYPLA1 Acyl-protein thioesterase 1 0 139989000.0 46518000.0 43631000.0 49840000.0 False True 70571206.92133527 35844707.159441054 39989102.154352024 1.0 0.5079225469304591 0.5666489762450473 26.072576347640826 -10.13990016202653 5.2254894354896315 1.0000148207522275 0.5372857615883417 0.9880632119527528 0.02397496437396981 4.139735386784702e-06 6.813407088747306e-07 0.02321440239947514 0.007737886478679507 7.246025164904773e-11 10.13990016202653 -0.46272905916388574 IILGGFSQGGALSLYTALTTQQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IILGGFSQGGALSLYTALTTQQK 23 0 O75608;O75608-2;A0A087X1K9;E5RGR0;E5RJ48 O75608 LYPLA1 Acyl-protein thioesterase 1 0 100715000.0 46518000.0 30810000.0 23387000.0 False True 60218468.006866805 29095396.415833317 19130805.970884383 1.0 0.4831640089634217 0.31769001444378936 25.843702669733275 -13.999999999999998 0.15934292643777437 3.541841710361985 0.15383578976160456 0.9995381113358935 0.00624550732680935 12.005354235497597 0.12612343199042378 9.43172491972116 0.1492160360093503 1.0000000000000041e-14 13.999999999999998 -3.3880059206003805 IILLAEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IILLAEGR 8 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 17298400.0 5728400.0 5442300.0 6127700.0 False True 7509987.873904507 4630330.05391925 5493664.385048945 1.0 0.6165562623620992 0.7315144148418901 22.84037914760008 -10.526892674184067 9.220799598165014 1.0000141495516877 0.6740353386019953 0.9146767442514152 0.046931469224758736 1.365198222812201e-05 7.004808850381014e-07 0.04544316742320976 0.015147066560044711 2.9724005008757995e-11 10.526892674184067 -0.3259788109496924 IILLAEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IILLAEGR 8 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 7138400.0 2808900.0 1337900.0 2991600.0 False True 2719733.0070141237 1872130.4470563289 2208010.213923749 1.0 0.6883508205504552 0.811848151355058 21.37503360007815 -10.197757210496798 4.798555215719383 1.000035331360509 0.7500994859519141 0.8451907677209458 0.050417574180731214 1.905970693038594e-05 3.186537134395567e-06 0.04882350013466466 0.01627220209610002 6.342241710630179e-11 10.197757210496798 -0.24993584540859493 IILLAEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IILLAEGR 8 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 17361000.0 5728400.0 7039500.0 4593100.0 False True 7846344.284189234 6728471.61348649 3508304.3778638323 1.0 0.8575294901403561 0.4471259800482164 22.90358920912297 -6.952359738712479 0.532306372141143 1.0063673796095194 0.27958366417418007 0.9993736998354708 0.005865545398807078 0.08255178421467094 0.03214606879443658 0.006521853359034237 0.033948585638175856 1.115938500617365e-07 6.952359738712479 -0.7267837154353394 down IILLAEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IILLAEGR 8 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 6811300.0 2808900.0 2354600.0 1647800.0 False True 2335724.8053687927 2341915.302448494 1992347.361433624 1.0 1.0026503537854596 0.8529889124155823 21.155438875512427 -6.90286946555356 0.9429443369509267 1.0057420131553894 0.8363306371443662 0.9879407388880879 0.00767985984112304 0.10932399463212027 0.16574502526556592 0.006073871636964293 0.016043380811338454 1.25063487289175e-07 6.90286946555356 -0.16941137601102318 IILLAEGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IILLAEGR 8 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 8737100.0 2384200.0 4023700.0 2329200.0 False True 3086393.8996081464 3799777.557883434 1905309.4996102087 1.0 1.231138241416904 0.6173254489169739 21.557490766277116 -6.804666021917778 1.4365728076549547 1.1267828997584595 0.6078210773085057 0.8455273493331613 0.09948405484172047 0.21415256282514344 0.8719430478228125 0.054465368334861146 0.12633615782920413 1.567956385368114e-07 6.804666021917778 -0.5189618224499538 IILLKPIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IILLKPIIK 9 1 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 10107000.0 3361800.0 2947800.0 3797400.0 False True 4407352.35571751 2507999.7304344024 3404481.4752329295 1.0 0.5690490634770462 0.7724550252526123 22.071480810056944 -10.058487785679015 4.9052228810132545 1.0000079285863968 0.670752044361721 0.7774550530125818 0.0830401361757755 7.200402519839565e-06 1.3820345893367802e-06 0.08040520161247881 0.026801088704765576 8.740015731139037e-11 10.058487785679015 -0.3292558842246758 IILLKPIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IILLKPIIK 9 1 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 9460900.0 2844900.0 1821000.0 4795000.0 False True 2754590.206719531 2548134.7963895504 3539045.653083427 1.0 0.9250504086501308 1.2847811788665695 21.39340627806344 -6.85235556902817 1.223814258154805 0.9599107852318843 1.2998162607752042 0.9436379326864881 0.03678948292262912 0.1548931768399966 0.44525963950157255 0.023508791192967584 0.054484149950689106 1.4048968248507115e-07 6.85235556902817 0.33990547554331985 IILLKPIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IILLKPIIK 9 1 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 11293500.0 3361800.0 2467400.0 5464300.0 False True 4604748.309228996 2358382.1093993224 4173744.8807910434 1.0 0.5121630871056668 0.9064002200567357 22.134690871579835 -9.950411739503638 6.849302929693232 1.000000018815878 0.7092816535812005 0.420306996104713 0.16094663556465377 4.620743286898328e-08 7.119682445674079e-09 0.15583591908103286 0.05194530326416746 1.1209552116944487e-10 9.950411739503638 -0.2907183652346774 IILLKPIIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IILLKPIIK 9 1 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 6459100.0 2844900.0 1454600.0 2159600.0 False True 2365660.400439207 1446763.7810845063 2611162.375137797 1.0 0.6115686684428167 1.10377735310318 21.173811553497718 -6.696352378187036 1.8442307685759496 0.7579397661811613 1.1022011361055442 0.40017076150684894 0.16407377838893605 0.40313428532851353 2.6631377187504306 0.07105095377082361 0.1835275431328962 2.0120910154260653e-07 6.696352378187036 0.34426136992438283 IILNAVFGFINNPKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IILNAVFGFINNPKPK 16 1 A0A494BZT7;O14656;O14656-2 A0A494BZT7 TOR1A Torsin-1A 0 6355700.0 3576700.0 1650100.0 1128900.0 False True 3463159.6162865944 2308993.535157821 833207.2237259396 1.0 0.6667303246142785 0.24059163193273603 21.72365745189781 -7.315130432932928 0.3777545179388882 1.0394380822049076 3.6137453010910397e-23 0.9995736268548193 0.006417624464231922 0.10431660765831388 0.030552610048566096 0.012376700231016466 0.05258698194925007 4.8402697651372856e-08 7.315130432932928 -1.0394380822049076 down IILNAVFGFINNPKPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IILNAVFGFINNPKPK 16 1 A0A494BZT7;O14656;O14656-2 A0A494BZT7 TOR1A Torsin-1A 0 35172000.0 11232000.0 11950000.0 11990000.0 False True 17039765.169191215 9817429.134223843 9620171.244596306 1.0 0.5761481473919762 0.5645718206252089 24.022402117640443 IILNAVFGFINNPKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IILNAVFGFINNPKPK 16 1 A0A494BZT7;O14656;O14656-2 A0A494BZT7 TOR1A Torsin-1A 0 8812200.0 3576700.0 1900300.0 3335200.0 False True 2974184.5246760515 1890062.7067199808 4032574.8997775344 1.0 0.6354893891211564 1.3558590149065357 21.504062727332087 -6.769126296600865 1.5776824881432019 0.7906962828205457 1.3597899024851436 0.7272654313887765 0.15358906657710886 0.26783590801416557 1.315537524252064 0.07673899166833806 0.18282605908741206 1.7016635779107603e-07 6.769126296600865 0.5690936196645979 IILNAVFGFINNPKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IILNAVFGFINNPKPK 16 1 A0A494BZT7;O14656;O14656-2 A0A494BZT7 TOR1A Torsin-1A 0 26203900.0 11232000.0 8551200.0 6420700.0 False True 14540045.41582027 8075318.202891066 5252198.481945421 1.0 0.5553846615984246 0.36122297638979695 23.793528439732892 -13.999999999999998 0.1126645612005508 3.136164644287249 0.018324170388318798 0.9997295560201795 0.004397071357313501 11.997624508266425 0.10228036817760439 5.802239368325291 0.3043959880778428 1.0000000000000041e-14 13.999999999999998 -3.11784047389893 IILPEGAK(ub)NIEIDSPYEISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IILPEGAKNIEIDSPYEISR 20 1 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 1 152853800.0 4826800.0 56483000.0 91544000.0 True False 7322608.486347245 46403167.34630674 73450288.27483939 1.0 6.336972327938039 10.030617970602274 22.80392623148901 -8.125844330365108 0.3408980660608269 3.6177633124808366e-20 11.731204378411448 0.9982697827146999 0.1541969964214688 0.09788984440666526 0.08098044603959392 0.7242347344688844 0.9941577823268695 7.484377243863006e-09 8.125844330365108 11.731204378411448 IILPEGAK(ub)NIEIDSPYEISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IILPEGAKNIEIDSPYEISR 20 1 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 1 101007800.0 4826800.0 31754000.0 64427000.0 True False 6248387.750452401 29986861.98599063 52701947.07684477 1.0 4.79913590250853 8.43448729202649 22.57505255358146 -7.417064039906961 0.28289402658032486 1.2262783173282348e-18 11.713627183245789 0.9997988055965628 0.043054491998615434 0.12943743011214406 0.02705153194189482 0.22783929222177407 0.6817824699668478 3.827682971621551e-08 7.417064039906961 11.713627183245789 IINADSEDPK(ub)YIINVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IINADSEDPKYIINVK 16 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 13379100.0 5235400.0 3893800.0 4249900.0 True False 6863660.099685712 3312860.2179135224 3810161.115919428 1.0 0.48266670694622815 0.5551208918538807 22.710546679177998 -10.598653923489078 6.473789697668298 1.001213419189853 0.5188937994001777 0.9832744247001041 0.029579297125501773 0.0005191712676158372 3.218624410986886e-05 0.02870284879990952 0.009546677096632435 2.5196839900991572e-11 10.598653923489078 -0.4823196197896753 IINADSEDPK(ub)YIINVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IINADSEDPKYIINVK 16 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 41534700.0 21478000.0 11188000.0 8868700.0 True False 32583696.252126895 9191413.987757009 7115797.557710703 1.0 0.28208628992350865 0.21838521641774208 24.95764693480739 -13.999999999999998 0.3428753064810935 9.450583361514303 0.20873608570452554 0.999740903068042 0.005704555531035135 19.970786142475205 0.1880140167141948 122.49530088730943 0.01948162295354204 1.0000000000000041e-14 13.999999999999998 -9.241847275809777 IINADSEDPK(ub)YIINVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IINADSEDPKYIINVK 16 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 16093400.0 5235400.0 6472500.0 4385500.0 True False 7171068.861365179 6186523.548304752 3349735.222207624 1.0 0.8627059184489556 0.4671179829627134 22.77375674070089 -6.9523551011351445 0.5323688036468666 1.0061348283690352 0.3056582399958504 0.9993733337684155 0.005655176656549381 0.08255375490450798 0.032154555894799056 0.0062873758426097255 0.03272325969959139 1.1159504171370188e-07 6.9523551011351445 -0.7004765883731848 down IINADSEDPK(ub)YIINVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IINADSEDPKYIINVK 16 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 44293700.0 21478000.0 13004000.0 9811700.0 True False 27803694.394674867 12280315.968565302 8026071.276543662 1.0 0.44167928888318175 0.2886692380736592 24.72877325689984 -13.999999999999993 0.18163617617487562 3.9115821029142595 0.16915663812329104 0.9994962562278601 0.006861417532674924 12.226341256373317 0.13511815433641405 12.568095150058015 0.11267382939902743 1.0000000000000164e-14 13.999999999999993 -3.7424254647909683 IINADSEDPKYIINVK(ub)QFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IINADSEDPKYIINVKQFAK 20 2 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 86839000.0 15252000.0 20115000.0 51472000.0 True False 23138399.07055775 16525321.090787664 41298536.639020935 1.0 0.714194661454135 1.7848484898668244 24.463785713062 -6.835679367150027 1.3022903387530176 0.8477742062834128 1.8171599634165592 0.9167700396996439 0.13058571959482418 0.17390640308672992 0.5747731423699053 0.07867897609435405 0.1811067598691596 1.4598916777877085e-07 6.835679367150027 0.9693857571331463 IINADSEDPKYIINVK(ub)QFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IINADSEDPKYIINVKQFAK 20 2 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 72069000.0 15252000.0 18708000.0 38109000.0 True False 19744014.661867075 17666883.3543463 31173553.031360738 1.0 0.8947969122241144 1.578886237942696 24.234912035154448 -6.8676505809835975 1.1463638067587916 0.9412607080514688 1.6172156437175318 0.9622862627589918 0.058409316162309224 0.13913219614893524 0.3431837357451291 0.03959442155409471 0.0933836234637389 1.356280191799611e-07 6.8676505809835975 0.675954935666063 IINDLLQSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IINDLLQSLR 10 0 A0A087WTP3;Q92945 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 117964000.0 48930000.0 26168000.0 42866000.0 False True 64147703.83879404 22263836.402065087 38430637.51970691 1.0 0.3470714471404163 0.5990960739028909 25.934894289313362 -10.296059924274525 5.683178458515447 1.0000526168093526 0.4730837605217208 0.8535489498338116 0.10288862303059258 6.860063040160231e-05 8.497130429885708e-06 0.09963138091569784 0.033207160292638704 5.057548727562153e-11 10.296059924274525 -0.5269688562876318 IINDLLQSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IINDLLQSLR 10 0 A0A087WTP3;Q92945 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 169837000.0 83710000.0 35577000.0 50550000.0 False True 81052671.87053728 49783081.63160407 37309438.53250618 1.0 0.6142065459744611 0.4603110257993629 26.272356408632195 -13.999999999999998 0.12678163515408755 2.833383193667741 0.23571547771156348 0.9996604197795375 0.0041831909661283586 11.94288273287369 0.11039660143642195 5.473205659821552 0.1995322544681478 1.0000000000000041e-14 13.999999999999998 -2.5976677159561774 IINDLLQSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IINDLLQSLR 10 0 A0A087WTP3;Q92945 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 75959000.0 24330000.0 32862000.0 18767000.0 False True 36910388.76125557 26997519.348022066 15057694.224131703 1.0 0.7314341640411294 0.40795273985132335 25.137523597161675 -6.9686469052109326 0.2886832348757003 1.0642098434478335 0.06520116930254188 0.9999698189371017 0.0013297370757147438 0.07674423978835629 0.010593908598530719 0.005691713755722148 0.02937971304377026 1.074862953869868e-07 6.9686469052109326 -0.9990086741452917 down IINDLLQSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IINDLLQSLR 10 0 A0A087WTP3;Q92945 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 177166000.0 48930000.0 55984000.0 72252000.0 False True 67020743.28353109 53510441.765669 55187565.67664925 1.0 0.7984161193094086 0.8234400720263335 25.998104350836254 -9.765587971903143 5.855772337767553 1.000000011173554 0.8109280957295539 0.9870326643523505 0.010215985920870413 1.4942487058355473e-09 3.0205299779735496e-10 0.009891586422189255 0.0032971952775350017 1.7155841614029822e-10 9.765587971903143 -0.18907191544400015 IINDLLQSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IINDLLQSLR 10 0 A0A087WTP3;Q92945 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 127434000.0 83710000.0 19819000.0 23905000.0 False True 69608573.9817799 19712231.11323649 28903424.975768153 1.0 0.28318682578379184 0.4152279428010355 26.05276168406647 -10.68928942385461 14.232825942654697 1.0000246123491734 0.3492073843098555 0.970050554712541 0.053905560293228606 4.2101441932623304e-05 9.19083755414845e-07 0.05219577430194731 0.017397944773637847 2.045081293173941e-11 10.68928942385461 -0.6508172280393179 IINDLLQSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IINDLLQSLR 10 0 A0A087WTP3;Q92945 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 73313000.0 24330000.0 30689000.0 18294000.0 False True 31495664.615999594 28981130.172200907 14964679.71229142 1.0 0.9201625215896756 0.4751345905775698 24.908649919254124 -6.93741231050209 0.6832115133406649 1.0052890644493444 0.36374033471475803 0.9978049642408567 0.010818779971298443 0.08896720652578864 0.060135473643641975 0.010335222734207256 0.03875951516171773 1.1550151731834406e-07 6.93741231050209 -0.6415487297345863 down IINDYEEFSK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IINDYEEFSKER 12 1 Q14790;Q14790-9;Q14790-7;E7ETB7;Q14790-5 Q14790;Q14790-5 CASP8 Caspase-8;Caspase-8 subunit p18;Caspase-8 subunit p10 1 5723650.0 980750.0 1879600.0 2863300.0 True False 949616.6280854086 2630134.081984511 2113315.8328412445 1.0 2.7696798941772074 2.2254410573054675 19.856985671681088 -10.091003736260973 5.015587523542411 0.9999586730128728 2.4975604757470715 0.9098734820637449 0.2221845747768224 0.00010267936992479114 1.8608384552757058e-05 0.21513517593426495 0.07170976315505315 8.109540811381704e-11 10.091003736260973 1.4976018027341986 IINDYEEFSK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 IINDYEEFSKER 12 1 Q14790;Q14790-9;Q14790-7;E7ETB7;Q14790-5 Q14790;Q14790-5 CASP8 Caspase-8;Caspase-8 subunit p18;Caspase-8 subunit p10 1 37477500.0 2238800.0 6534700.0 28704000.0 True False 3396423.27820382 5368531.729155868 23030641.818589892 1.0 1.5806427201249744 6.780851481729781 21.695584834844173 -6.928058579569336 0.7625568754386571 0.9149635789283668 7.797505675467237 0.9961427786540515 0.16142065464699287 0.09365852025016382 0.08271039639197518 0.14539817392661852 0.4756513540049451 1.1801614394968865e-07 6.928058579569336 6.88254209653887 up IINDYEEFSK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IINDYEEFSKER 12 1 Q14790;Q14790-9;Q14790-7;E7ETB7;Q14790-5 Q14790;Q14790-5 CASP8 Caspase-8;Caspase-8 subunit p18;Caspase-8 subunit p10 1 4268250.0 980750.0 1086700.0 2200800.0 True False 815537.0795918138 1080845.7314069374 2660977.1046505207 1.0 1.32531770590727 3.26285238432368 19.637390947115364 -6.935991052403791 0.695855313894269 0.9760279076013096 3.7289907591572975 0.9975903077958932 0.049035061013835576 0.08964396894540488 0.06329954183605603 0.04639006212653345 0.16991217897793381 1.1588012302293277e-07 6.935991052403791 2.7529628515559876 up IINDYEEFSK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IINDYEEFSKER 12 1 Q14790;Q14790-9;Q14790-7;E7ETB7;Q14790-5 Q14790;Q14790-5 CASP8 Caspase-8;Caspase-8 subunit p18;Caspase-8 subunit p10 1 43050400.0 2238800.0 5719600.0 35092000.0 True False 2898170.733345658 5401299.232067516 28705616.074326586 1.0 1.8636925595588492 9.90473602677946 21.466711156936622 -6.927389671447998 0.7679209546396757 0.8651544707367458 11.450871620334086 0.99599980738938 0.2536012934914098 0.09401601915054865 0.08448894842675897 0.2275519439083326 0.7382940275760688 1.1819805457844246e-07 6.927389671447998 10.58571714959734 up IINEPTAAAIAYGLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IINEPTAAAIAYGLDK 16 0 P11142;E9PKE3;P11142-2;E9PLF4;P54652;E9PI65;Q53FA3;P34931;E9PN89;P11021 P11142;Q53FA3;E9PN89;P11021 HSPA8;HSPA2;HSPA1L;HSPA5 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1-like;78 kDa glucose-regulated protein 0 332649000.0 63109000.0 132460000.0 137080000.0 False True 82736510.14842546 112697484.32503588 122896276.56420992 1.0 1.3621251866057902 1.4853935263131077 26.30202076974515 -12.27915092959154 0.1745236478197667 1.5518717611697681e-10 1.5988659989739973 0.9994851050699342 0.00467448064986487 6.058429051476116 0.11720163274150096 2.2496122625633737 0.09564533654605205 5.25834492303863e-13 12.27915092959154 1.59886599881881 IINEPTAAAIAYGLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IINEPTAAAIAYGLDK 16 0 P11142;E9PKE3;P11142-2;E9PLF4;P54652;E9PI65;Q53FA3;P34931;E9PN89;P11021 P11142;Q53FA3;E9PN89;P11021 HSPA8;HSPA2;HSPA1L;HSPA5 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1-like;78 kDa glucose-regulated protein 0 262874000.0 80393000.0 38481000.0 144000000.0 False True 77840968.21990342 53846663.97576393 106282080.09259915 1.0 0.6917522380200263 1.36537459031019 26.214026319312136 -6.782283794653818 1.5268281235807433 0.8259746063829654 1.3711094295233353 0.7753948990509959 0.13048801362862458 0.24706482893139026 1.1377333919167492 0.06730042688049412 0.15850996090306219 1.6508826576864977e-07 6.782283794653818 0.5451348231403699 IINEPTAAAIAYGLDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IINEPTAAAIAYGLDK 16 0 P11142;E9PKE3;P11142-2;E9PLF4;P54652;E9PI65;Q53FA3;P34931;E9PN89;P11021 P11142;Q53FA3;E9PN89;P11021 HSPA8;HSPA2;HSPA1L;HSPA5 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1-like;78 kDa glucose-regulated protein 0 415056000.0 16272000.0 377640000.0 21144000.0 False True 24685813.642546304 310247191.4852127 16964879.13225559 1.0 12.56783333041524 0.687231921050251 24.557178861193385 -6.652267646919849 2.000424662322128 8.493025801125226 0.7371784182205644 0.20326856271274818 4.934571582154545 0.5030141513825769 3.860849558184546 1.9987686954393302 5.4664096316351465 2.2270622327785563e-07 6.652267646919849 -7.755847382904662 IINEPTAAAIAYGLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IINEPTAAAIAYGLDK 16 0 P11142;E9PKE3;P11142-2;E9PLF4;P54652;E9PI65;Q53FA3;P34931;E9PN89;P11021 P11142;Q53FA3;E9PN89;P11021 HSPA8;HSPA2;HSPA1L;HSPA5 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1-like;78 kDa glucose-regulated protein 0 353049000.0 63109000.0 161760000.0 128180000.0 False True 86442102.75659858 154612908.3312131 97906523.94996546 1.0 1.788629653845512 1.1326254316793762 26.36523083126804 -10.200779986360585 4.624784870360087 0.9999134157555941 1.4606275426586588 0.3966429083181904 0.26781260227222903 188280862.37027478 31.97675836666283 185882.0393162288 0.09167937714981211 6.29825171562022e-11 10.200779986360585 0.4607141269030647 IINEPTAAAIAYGLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IINEPTAAAIAYGLDK 16 0 P11142;E9PKE3;P11142-2;E9PLF4;P54652;E9PI65;Q53FA3;P34931;E9PN89;P11021 P11142;Q53FA3;E9PN89;P11021 HSPA8;HSPA2;HSPA1L;HSPA5 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1-like;78 kDa glucose-regulated protein 0 149856000.0 80393000.0 32623000.0 36840000.0 False True 66850341.51376468 32447253.42384146 44543073.6710855 1.0 0.48537154319788295 0.6663103383236113 25.994431594746413 -10.059183695285673 5.6906353803590415 1.0000018779593922 0.5758409407606538 0.8799103483335148 0.07386795378900117 1.759943402925752e-06 2.910421688786116e-07 0.0715226551995256 0.023840779570220134 8.726022022528004e-11 10.059183695285673 -0.4241609371987384 IINEPTAAAIAYGLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IINEPTAAAIAYGLDK 16 0 P11142;E9PKE3;P11142-2;E9PLF4;P54652;E9PI65;Q53FA3;P34931;E9PN89;P11021 P11142;Q53FA3;E9PN89;P11021 HSPA8;HSPA2;HSPA1L;HSPA5 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1-like;78 kDa glucose-regulated protein 0 71605000.0 16272000.0 35070000.0 20263000.0 False True 21064424.769073006 33118323.670992345 16575341.915937487 1.0 1.5722396426232816 0.7868879448478254 24.328305183285835 -6.711296460836411 1.7902930078772086 1.3513232161512405 0.7886365708445411 0.47141397829297194 0.24108927423498208 0.37246325445255385 2.327839865703922 0.1071261536624447 0.27175335994881694 1.9440325808080012e-07 6.711296460836411 -0.5626866453066994 IINEPTAAAIAYGLDK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 IINEPTAAAIAYGLDKK 17 1 P11142;E9PKE3;P11142-2;P54652;E9PI65;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 125185100.0 1986300.0 76523800.0 46675000.0 True False 2604058.5353565626 65106747.327436194 41845518.73821489 1.0 25.002029118566416 16.069346433675754 21.312330447827524 -9.193980834807268 11.984321869193042 1.0000000028791907 20.535687716386317 0.86444783545307 3.646752435362802 0.0 0.0 3.5309528624753503 1.176984287491783 6.39763067275733e-10 9.193980834807268 19.535687713507127 IINEPTAAAIAYGLDK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 IINEPTAAAIAYGLDKK 17 1 P11142;E9PKE3;P11142-2;P54652;E9PI65;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 198023900.0 2086300.0 110917600.0 85020000.0 True False 2020071.548482885 155207576.10764265 62750711.454672106 1.0 76.83271229883255 31.063608366643834 20.945974961713823 -10.406820167683223 7.113020542894918 0.9968105718847428 53.94816033273636 0.6408580286816732 18.685158436379254 0.944350704375394 0.07875215243157106 18.043152961441205 6.030608953778601 3.919041228644831e-11 10.406820167683223 52.95134976085161 IINEPTAAAIAYGLDK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 IINEPTAAAIAYGLDKK 17 1 P11142;E9PKE3;P11142-2;P54652;E9PI65;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 486542600.0 7050700.0 162689900.0 316802000.0 True False 10696427.375215145 133656616.24300957 254185945.84075063 1.0 12.495444652174927 23.763630315457362 23.35062567871447 -7.601563909429964 0.37517075322205373 2.8052155872665286e-18 29.283644104120143 0.9981829332679346 0.3961489885914986 0.15196793618682714 0.0631744487143316 0.8421410818163424 2.4819719023854137 2.5028573085574506e-08 7.601563909429964 29.283644104120143 IINEPTAAAIAYGLDK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IINEPTAAAIAYGLDKK 17 1 P11142;E9PKE3;P11142-2;P54652;E9PI65;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 48790100.0 1986300.0 1899800.0 44904000.0 True False 2720688.7877391744 1815860.554201524 34298600.02690945 1.0 0.6674267789777086 12.60658704570571 21.375540509350415 -6.900492345282611 0.9581464317274769 0.5102971928027366 13.872425572366408 0.9868097786361035 0.6375763427451402 0.11104389939792214 0.17538139009597054 0.49860657354764737 1.3005284051261634 1.2574990183950037e-07 6.900492345282611 13.362128379563671 up IINEPTAAAIAYGLDK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IINEPTAAAIAYGLDKK 17 1 P11142;E9PKE3;P11142-2;P54652;E9PI65;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 5692300.0 2086300.0 3606000.0 0.0 True False 1734850.8887610526 3586573.762265038 0.0 1.0 2.0673671642330005 0.0 20.7263802371481 -6.771478297576869 1.602332878355279 1.614779918558094 8.099973458592349e-11 0.7162995574858065 0.4496233332079009 0.2686092667844316 1.3666910362027749 0.22238623073506428 0.521551253690127 1.6924728180265313e-07 6.771478297576869 -1.6147799184770943 IINEPTAAAIAYGLDK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IINEPTAAAIAYGLDKK 17 1 P11142;E9PKE3;P11142-2;P54652;E9PI65;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 180901100.0 7050700.0 167978400.0 5872000.0 True False 9127270.140075142 158630254.37511897 4803356.251807973 1.0 17.37981367272351 0.5262642803479495 23.121752000806918 -6.555901486144744 2.363791773953471 9.999999999999998 0.5510032718868798 0.26309682067496787 6.726289993758935 0.5376513881825598 5.62713551238001 2.610843070237104 8.146269647088534 2.7803438798042527e-07 6.555901486144744 -9.44899672811312 IINEPTAAAIAYGLDK(ub)K(ub)VGAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IINEPTAAAIAYGLDKKVGAER 22 2 P11142;E9PKE3;P11142-2;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 2 26911700.0 7899900.0 8494800.0 10517000.0 True False 7649121.998686627 11886817.939796792 7762282.196762946 1.0 1.554010766443232 1.0147938806696704 22.86686272747769 -10.434675288320241 3.02635939867747 0.9944754436163313 1.2844023229695132 0.27056179901079436 0.220134376944532 59194704.045948125 73110365.30134529 2808998.7887320383 0.08699797244863562 3.675570114444136e-11 10.434675288320241 0.28992687935318184 IINEPTAAAIAYGLDK(ub)K(ub)VGAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 IINEPTAAAIAYGLDKKVGAER 22 2 P11142;E9PKE3;P11142-2;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 2 72716000.0 9147000.0 25793000.0 37776000.0 True False 13876667.735273536 21190037.62837116 30309557.042191025 1.0 1.5270263749637487 2.184210043823865 23.72615783306679 -6.968145441574996 0.29918799350769165 0.8849168831766642 2.8468880451059917 0.9999640866335648 0.0029030396245732105 0.07690920115677326 0.011172721255125369 0.01094703157652057 0.058990760452444974 1.0761047748267535e-07 6.968145441574996 1.9619711619293274 IINEPTAAAIAYGLDK(ub)K(ub)VGAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IINEPTAAAIAYGLDKKVGAER 22 2 P11142;E9PKE3;P11142-2;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 2 26438500.0 7899900.0 8857100.0 9681500.0 True False 6569116.8749093665 8809385.0443033 11705856.887801694 1.0 1.3410303412244955 1.7819529033669688 22.647268002911968 -6.9676084349398195 0.3100381263346185 0.9321027951059806 2.2048968271945957 0.9999572604098428 0.002092649653901898 0.0770866248565606 0.011793953005725211 0.006975076951659781 0.03914405805186954 1.0774362051075778e-07 6.9676084349398195 1.272794032088615 IINEPTAAAIAYGLDK(ub)K(ub)VGAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IINEPTAAAIAYGLDKKVGAER 22 2 P11142;E9PKE3;P11142-2;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 2 52558000.0 9147000.0 17839000.0 25572000.0 True False 11840971.81432588 16846243.968258724 20918158.39087768 1.0 1.4227078851650656 1.7665913506837085 23.49728415515924 -6.9734767371897615 0.153928888370114 0.6215531161428988 2.5768213501726684 0.9999983685666521 0.00040039787041979037 0.07518983884052557 0.0047229327630545935 0.016880859795144195 0.0422300917614563 1.0629755196093883e-07 6.9734767371897615 1.9552682340297696 IINEPTAAAIAYGLDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IINEPTAAAIAYGLDKK 17 1 P11142;E9PKE3;P11142-2;P54652;E9PI65;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 126155100.0 24501100.0 48446000.0 53208000.0 False True 32121179.368989926 41218045.64102897 47702546.567175925 1.0 1.2832046161051371 1.485080794176206 24.937021528379248 -6.974780318570547 0.086726542237677 0.37330434033813287 2.4000640755067453 0.9999998587241519 7.455888627685216e-05 0.07477963694676804 0.0025250865866336424 0.021927183463694436 0.036799649902678824 1.0597896685190447e-07 6.974780318570547 2.0267597351686124 IINEPTAAAIAYGLDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IINEPTAAAIAYGLDKK 17 1 P11142;E9PKE3;P11142-2;P54652;E9PI65;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 89802500.0 27973000.0 15377500.0 46452000.0 False True 27085012.426646087 21517815.94260311 34284827.66987096 1.0 0.7944547192244963 1.265822851760693 24.690991416931396 -6.7881761972981005 1.5034937572413805 0.8848467798709059 1.2705950005585736 0.7953867333858169 0.08728345411622385 0.2380875470022125 1.0632323258580592 0.04569875642615059 0.10714127977957771 1.6286351462053378e-07 6.7881761972981005 0.3857482206876677 IINEPTAAAIAYGLDKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IINEPTAAAIAYGLDKK 17 1 P11142;E9PKE3;P11142-2;P54652;E9PI65;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 569494000.0 19351000.0 525354000.0 24789000.0 False True 29356881.747597896 431600474.09046316 19889443.284595348 1.0 14.701850073902298 0.6775053105298824 24.807195399211775 -6.651548045433298 2.003112902397557 9.88064675921336 0.7371273608516379 0.20010897409937867 5.84598297004008 0.5049313726680337 3.8852157186182366 2.3654989870174137 6.475290418579857 2.2307554082631847e-07 6.651548045433298 -9.143519398361722 IINEPTAAAIAYGLDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IINEPTAAAIAYGLDKK 17 1 P11142;E9PKE3;P11142-2;P54652;E9PI65;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 126075100.0 24501100.0 58054000.0 43520000.0 False True 33559818.78733137 55488982.32109443 33241472.322534706 1.0 1.6534350996567713 0.9905140588864908 25.00023158990214 -6.649502833431956 2.010739846521863 1.424186430078717 0.9933207412311945 0.19194035191192838 0.2789283690850431 0.5096959312950621 3.949559609785082 0.11253653136451698 0.30886054148225245 2.241285423099514e-07 6.649502833431956 -0.4308656888475225 IINEPTAAAIAYGLDKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IINEPTAAAIAYGLDKK 17 1 P11142;E9PKE3;P11142-2;P54652;E9PI65;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 46248600.0 27973000.0 10916800.0 7358800.0 False True 23260788.91401664 10857989.031584851 8897491.056753095 1.0 0.4667936703145082 0.3825102875763421 24.471396692365673 -13.999999999999998 0.2596534505092925 4.896281340787936 0.35160285758917165 0.9995616274478741 0.005724175284503572 14.401760651707072 0.1612486790530608 29.436948224151266 0.03691481120299907 1.0000000000000041e-14 13.999999999999998 -4.544678483198764 IINEPTAAAIAYGLDKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IINEPTAAAIAYGLDKK 17 1 P11142;E9PKE3;P11142-2;P54652;E9PI65;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 83054700.0 19351000.0 35763700.0 27940000.0 False True 25050250.96523668 33773418.65618106 22855206.68860951 1.0 1.3482267584085246 0.9123743598547844 24.578321721304224 -6.693894627661361 1.8523627384425017 1.2175093112211524 0.9137961237967722 0.38883394702203455 0.1471603064362671 0.40833807465920713 2.7193739258950385 0.06348124355451593 0.16451566827939465 2.023510080896843e-07 6.693894627661361 -0.30371318742438014 IINEPTAAAIAYGLDKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IINEPTAAAIAYGLDKK 17 1 P11142;E9PKE3;P11142-2;P54652;E9PI65;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 265746000.0 104150000.0 112930000.0 48666000.0 True False 86605339.62731305 112321623.67515019 58841835.59383952 1.0 1.2969364724912054 0.6794250313785773 26.367952640853638 -6.77596339494413 1.5517490193914443 1.1690151232753148 0.675151299783943 0.7527972079498513 0.12537244932331737 0.2568965420376752 1.2215345857229958 0.06365656262589497 0.1507080798216948 1.6750840566401386e-07 6.77596339494413 -0.4938638234913718 IINEPTAAAIAYGLDKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IINEPTAAAIAYGLDKR 17 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 91027000.0 15212000.0 39688000.0 36127000.0 False True 19943079.313217536 33766705.10261229 32388924.59465431 1.0 1.6931540296403957 1.624068384123014 24.24938485062355 -10.261034468853186 4.626310802610909 0.999748843225581 1.6586112068844319 0.9918151742610729 0.028204096687384772 7.308966751742624e-05 1.16747165263952e-05 0.0273187128822234 0.009102833062439444 5.482334512934551e-11 10.261034468853186 0.6588623636588509 IINEPTAAAIAYGLDKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IINEPTAAAIAYGLDKR 17 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 74594000.0 23414000.0 11808000.0 39372000.0 False True 22670735.386175644 16522995.977906529 29059292.065318134 1.0 0.7288248791427412 1.2817975054765167 24.4343278537367 -6.773366749764705 1.561664991844638 0.8451314589292251 1.2853043485659565 0.743244007567559 0.11439709859431584 0.2610161127528623 1.256736572460491 0.05772560265488237 0.13698539286758535 1.6851293788695457e-07 6.773366749764705 0.4401728896367314 IINEPTAAAIAYGLDKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IINEPTAAAIAYGLDKR 17 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 271463000.0 19745000.0 229450000.0 22268000.0 False True 29954608.552856214 188502854.79896742 17866720.03958886 1.0 6.292950030254807 0.5964598071132278 24.836274644683595 -6.662711781485658 1.9634575067265418 4.3995034223435505 0.6202516481580225 0.24702648786573245 2.252194060250078 0.47811290209802915 3.546144296349826 0.9258530670030434 2.4971719395427483 2.1741435654706543e-07 6.662711781485658 -3.779251774185528 IINEPTAAAIAYGLDKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IINEPTAAAIAYGLDKR 17 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 85060000.0 15212000.0 36151000.0 33697000.0 False True 20836287.488842715 34553729.28462958 25738462.611499358 1.0 1.6583438533919346 1.2352710445793968 24.31259491214644 -10.188966409451144 4.48466742541597 0.9998969884706547 1.4468074489937972 0.5979303565320461 0.1727187509672834 121286204.38424975 24.821354313014798 129021.45554621049 0.059126222501419134 6.471926709927499e-11 10.188966409451144 0.44691046052314254 IINEPTAAAIAYGLDKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IINEPTAAAIAYGLDKR 17 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 41840500.0 23414000.0 10059000.0 8367500.0 False True 19469778.416072123 10004810.170444835 10117105.56305126 1.0 0.5138635867671691 0.5196312637384554 24.214733129170977 -9.907987843011483 6.217191979964085 1.0000000785099925 0.5167474252531074 0.9998931754717786 0.0023546442637462496 2.561334668544906e-09 4.5080721731734764e-10 0.0022798748615248565 0.0007599581682712091 1.2359820311879383e-10 9.907987843011483 -0.48325265325688516 IINEPTAAAIAYGLDKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IINEPTAAAIAYGLDKR 17 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 70835000.0 19745000.0 26982000.0 24108000.0 False True 25560291.732137788 25480427.98091577 19720591.368969142 1.0 0.996875475755169 0.7715323273941275 24.607400966776044 -6.909920852566138 0.8962744179079958 1.00699454150601 0.7424598320629714 0.9908916495228387 0.010209142635780707 0.10447034579102353 0.13905160400166122 0.008355093417646725 0.023051186579711055 1.2304929999783968e-07 6.909920852566138 -0.2645347094430386 IINEPTAAAIAYGLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IINEPTAAAIAYGLDR 16 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;P17066 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 0 72931000.0 13328000.0 30715000.0 28888000.0 False True 17473137.068535607 26132441.726132296 25898946.873262983 1.0 1.4955781336592244 1.4822150579874966 24.058635312358508 -10.198052319714959 5.038370947166214 0.9999554661116511 1.4888965958238316 0.9994399880419463 0.005455452800003195 2.7294102605526204e-06 4.34427268805507e-07 0.005282699221312904 0.001760739819795264 6.337933531947367e-11 10.198052319714959 0.4889411297121805 IINEPTAAAIAYGLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IINEPTAAAIAYGLDR 16 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;P17066 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 0 72982600.0 24090000.0 9866600.0 39026000.0 False True 23325276.13619933 13806384.833639283 28803919.845095687 1.0 0.5919065975048698 1.2348801221861574 24.475390824729825 -6.7352200886826 1.7043243979236835 0.7558495078958773 1.2348684174130595 0.5832454585891882 0.1714936826945535 0.32653235355312377 1.8604256126184688 0.07966751983466208 0.19652243645608988 1.8398393843997824e-07 6.7352200886826 0.4790189095171822 IINEPTAAAIAYGLDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IINEPTAAAIAYGLDR 16 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;P17066 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 0 318832700.0 7884700.0 288630000.0 22318000.0 False True 11961666.34878224 237121721.42351732 17906837.51767312 1.0 19.823468947339226 1.4970186423479477 23.511915045860174 -6.454808991480806 2.8569752359548874 9.999999999999998 1.4328592342669788 0.2281916296950175 7.694722003478893 0.6614171497780278 10.018068341558152 2.9471552324162897 10.752656594461433 3.5090617324486865e-07 6.454808991480806 -8.567140765733019 IINEPTAAAIAYGLDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IINEPTAAAIAYGLDR 16 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;P17066 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 0 72609000.0 13328000.0 28000000.0 31281000.0 False True 18255721.775657117 26762867.41638209 23893072.052417442 1.0 1.4659988657402048 1.308799090281787 24.1218453738814 -10.046581818902762 6.175398855288778 0.9999994983525518 1.387398978011006 0.8900798893529221 0.06417653959223854 4.43220278981444e-07 6.852268344274145e-08 0.06213874781797929 0.02071288908815806 8.982933426667109e-11 10.046581818902762 0.38739947965845434 IINEPTAAAIAYGLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IINEPTAAAIAYGLDR 16 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;P17066 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 0 42338700.0 24090000.0 10881000.0 7367700.0 False True 20031902.367949825 10822381.893290602 8908252.005604144 1.0 0.5402573202735824 0.44470324595116645 24.2557961001641 -13.999999999999998 0.2208161058451437 3.784252361320007 0.39398914253619766 0.9994987230246313 0.005427289331573494 13.021955636834813 0.1488583033572506 15.816568033518205 0.052598775528346804 1.0000000000000041e-14 13.999999999999998 -3.3902632187838098 IINEPTAAAIAYGLDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IINEPTAAAIAYGLDR 16 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;P17066 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 0 61321700.0 7884700.0 30985000.0 22452000.0 False True 10206899.580672918 29260657.51199598 18365966.376974255 1.0 2.866752756870651 1.799367793502229 23.283041367952624 -10.608092500261236 6.150929709723006 0.9948208999292755 2.33306027518644 0.6752907544638656 0.43575808656199133 0.03090201694833232 0.001968924473882131 0.42128459626439607 0.14064031768581686 2.465514152131431e-11 10.608092500261236 1.3382393752571646 IINEVK(ub)PTEIYNLGAQSHVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IINEVKPTEIYNLGAQSHVK 20 1 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 1 69887900.0 4376900.0 11655000.0 53856000.0 True False 6640077.294251531 9575074.189069377 43211337.99407666 1.0 1.4420124593065717 6.507655871940786 22.662768604779558 -6.924067399875724 0.7939678316821518 0.9037505005882054 7.406211485697796 0.9952384225712003 0.17241903063177116 0.09583716842026582 0.09364017980370724 0.15185223060561542 0.47417912277308116 1.1910571488206885e-07 6.924067399875724 6.5024609851095905 up IINEVK(ub)PTEIYNLGAQSHVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IINEVKPTEIYNLGAQSHVK 20 1 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 1 54846100.0 4376900.0 6641200.0 43828000.0 True False 5665983.3315975685 6271611.381916015 35851753.71325611 1.0 1.1068884278111149 6.327543096239118 22.433894926872007 -6.911325984008438 0.8866622598172248 0.8450584236585438 7.021703390455995 0.991412288267677 0.23043456450961672 0.10354753787745113 0.13406145110131915 0.18990560992002134 0.5291648804067698 1.226518253695851e-07 6.911325984008438 6.1766449667974515 up IINFAPSLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IINFAPSLLR 10 0 O15397;F5H2I3 O15397 IPO8 Importin-8 0 2843290.0 969420.0 1393000.0 480870.0 False True 1270919.0078766327 1185169.829871472 431114.1852307522 1.0 0.9325297855538216 0.3392145231591345 20.277440663665615 -6.928380450719581 0.759973535749106 1.0095856467622923 0.22228784227361395 0.9962101419116269 0.018276162921587406 0.09348769076055435 0.08186575935141212 0.016492750816284953 0.05417085316663197 1.1792871037483989e-07 6.928380450719581 -0.7872978044886784 down IINFAPSLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IINFAPSLLR 10 0 O15397;F5H2I3 O15397 IPO8 Importin-8 0 3432440.0 1594200.0 771940.0 1066300.0 False True 1543592.9936209617 1080179.6676139191 787004.0416856842 1.0 0.6997826966550508 0.5098520432122003 20.557860969928292 -8.917556817942302 0.11071931532910556 1.587829474506186 2.756502599511255e-12 0.9999524969167852 0.0013907297123470397 0.40936316911970105 0.03403866668772987 0.26957033527891844 0.1954836194216846 1.2090469952177605e-09 8.917556817942302 -1.5878294745034296 IINFAPSLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IINFAPSLLR 10 0 O15397;F5H2I3 O15397 IPO8 Importin-8 0 4908420.0 969420.0 1675000.0 2264000.0 False True 1327840.7715904482 1600992.961515711 1729289.8285436244 1.0 1.2057115550067716 1.302332226530695 20.340650725188507 -13.935241573088133 0.10129296170864932 6.21231433570841e-17 1.5046534032133003 0.9997887481714626 0.0018324505145337333 11.821119382203511 0.09445098403825429 2.474599856782916 0.17953931909097612 1.1608027462995362e-14 13.935241573088133 1.5046534032133003 IINYRDDEK(ub)SFSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IINYRDDEKSFSR 13 2 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1;H3BQD1;H3BUV0;H3BTM1;H3BRA2 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 13082800.0 3204500.0 5726300.0 4152000.0 True False 4201130.532422146 4871958.360942573 3722390.8687963197 1.0 1.1596779303435887 0.8860450395599085 22.002346181511964 -6.74852148883292 1.655232111421238 1.0940592243437497 0.8855595180028849 0.6426008618091995 0.06709359633263166 0.3026405058071654 1.6309197494801784 0.032026041890918705 0.07787423157205345 1.7843436972684044e-07 6.74852148883292 -0.2084997063408648 IINYRDDEK(ub)SFSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IINYRDDEKSFSR 13 2 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1;H3BQD1;H3BUV0;H3BTM1;H3BRA2 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 14623700.0 5098000.0 4078100.0 5447600.0 True False 4936166.780504112 5706506.597010548 4020710.1355030737 1.0 1.1560603299606833 0.8145409817559798 22.234959709626192 -6.782464004273708 1.5262903761386029 1.0880824956003163 0.8116245594573904 0.7760058099470146 0.06606839618994617 0.24676462135561983 1.1355851406402524 0.03408849962064812 0.08026981821552095 1.6501977693615975e-07 6.782464004273708 -0.2764579361429259 IINYRDDEK(ub)SFSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IINYRDDEKSFSR 13 2 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1;H3BQD1;H3BUV0;H3BTM1;H3BRA2 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 122504000.0 26851000.0 57067000.0 38586000.0 True False 40734930.07104286 46882947.983493865 30959460.187155403 1.0 1.150927420317862 0.7600224213754937 25.279763095754333 -6.80201098608875 1.4475533609768174 1.083062246105435 0.7543459058260252 0.8380160515577166 0.06478221106508923 0.21789769903904208 0.9011696152977574 0.035202528666958416 0.08177484393793723 1.5775713623117794e-07 6.80201098608875 -0.32871634027940966 IINYRDDEK(ub)SFSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IINYRDDEKSFSR 13 2 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1;H3BQD1;H3BUV0;H3BTM1;H3BRA2 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 13776600.0 3204500.0 3963700.0 6608400.0 True False 4389290.248356335 3788570.6277969107 5047632.024270178 1.0 0.8631396907998106 1.149988207355477 22.065556243034855 -6.776961256526172 1.5477080840067339 0.9222009425619456 1.1520479778795865 0.7565004356431371 0.057806627039784474 0.2553194971039945 1.2077844707508099 0.029424117263658282 0.06960705962270668 1.671239699197042e-07 6.776961256526172 0.22984703531764084 IINYRDDEK(ub)SFSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IINYRDDEKSFSR 13 2 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1;H3BQD1;H3BUV0;H3BTM1;H3BRA2 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 16199900.0 5098000.0 6989300.0 4112600.0 True False 4239212.879693156 6951647.253632577 4972525.645486058 1.0 1.6398438698213602 1.1729832368894813 22.01536498506047 -10.270964339666506 4.647643087524867 0.9998337850198716 1.4064135533567697 0.5025907261357894 0.19059505528394513 0.0003283921163899442 5.151191566593256e-05 0.18461774639679876 0.06151428958136278 5.3584065409341304e-11 10.270964339666506 0.406579768336898 IINYRDDEK(ub)SFSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IINYRDDEKSFSR 13 2 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1;H3BQD1;H3BUV0;H3BTM1;H3BRA2 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 112030000.0 26851000.0 71966000.0 13213000.0 True False 34759148.81233887 67961028.83680174 10808369.576828808 1.0 1.9551983048755441 0.31095035252969233 25.050889417846783 -6.749210222307941 1.6527179538818546 1.5622004751822633 0.3078708303388166 0.6455762749352048 0.40136668195905745 0.3014298330436283 1.6196858745762852 0.19186108152149048 0.4661828055477209 1.7815162073149966e-07 6.749210222307941 -1.2543296448434467 IIPAIATTTAAVVGLVCLELYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIPAIATTTAAVVGLVCLELYK 22 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 2043360000.0 609240000.0 876980000.0 557140000.0 False True 924261621.4100848 720476067.123986 447021034.7968632 1.0 0.779515291379083 0.48365205742814765 29.783726037674025 -6.967042467468751 0.32107617343153955 1.0400101177895336 0.21359924785854686 0.9999492643679981 0.0015068058125821426 0.07727458809049609 0.012451555924881971 0.0044653174348835796 0.026000151195450214 1.0788412226254533e-07 6.967042467468751 -0.8264108699309867 down IIPAIATTTAAVVGLVCLELYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIPAIATTTAAVVGLVCLELYK 22 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 850759000.0 609240000.0 60459000.0 181060000.0 False True 788673189.9158081 57094403.50226771 148108937.83248514 1.0 0.07239298131633283 0.18779507117301142 29.554852359766475 -10.396802941553723 5.757684191716139 1.0002927211787311 0.13009402624504732 0.9869728564200991 0.04711270589995177 0.0001770848319097269 1.855204832388652e-05 0.045631336769762304 0.01520556044543928 4.010486497035844e-11 10.396802941553723 -0.8701986949336838 IIPGFMCQGGDFTR ddPTM_RPMI8226_Bortezomib_1h_R1 2 IIPGFMCQGGDFTR 14 0 P62937;F8WE65;C9J5S7;P0DN26;A0A0H2UH34;A0A0B4J2A2;A0A075B767;A0A075B759;Q9Y536;F5H284 P62937 PPIA;PPIAL4C;PPIAL4E;PPIAL4A;PPIAL4D Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C;Peptidyl-prolyl cis-trans isomerase A-like 4D 0 1271100830.0 289319290.0 444069240.0 537712300.0 False True 379300390.9619894 377815840.36033976 482074989.29659635 1.0 0.9960860820683983 1.2709583242821023 28.498765617782546 -6.903672561589162 0.9377750983673194 0.989694630915288 1.3020611321296958 0.9883060711639057 0.013913464330037558 0.1087517540186025 0.1625730054539073 0.011046153984732257 0.029307129830652943 1.2483243396608782e-07 6.903672561589162 0.3123665012144078 IIPGFMCQGGDFTR ddPTM_RPMI8226_Bortezomib_2h_R1 2 IIPGFMCQGGDFTR 14 0 P62937;F8WE65;C9J5S7;P0DN26;A0A0H2UH34;A0A0B4J2A2;A0A075B767;A0A075B759;Q9Y536;F5H284 P62937 PPIA;PPIAL4C;PPIAL4E;PPIAL4A;PPIAL4D Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C;Peptidyl-prolyl cis-trans isomerase A-like 4D 0 505192400.0 270776400.0 109028000.0 125388000.0 False True 262180751.39750788 152563448.9735089 92545121.24063069 1.0 0.5819017916467801 0.3529821344524164 27.965986529774018 -9.65099531310776 0.15042706795711355 1.6261748397023004 1.9089260586192496e-21 0.9997712559753378 0.004051505879217768 1.1143871810941788 0.06238350431628713 0.48017366421152213 0.18958256991278158 2.2335963276010103e-10 9.65099531310776 -1.6261748397023004 IIPGFMCQGGDFTR ddPTM_RPMI8226_Bortezomib_8h_R1 2 IIPGFMCQGGDFTR 14 0 P62937;F8WE65;C9J5S7;P0DN26;A0A0H2UH34;A0A0B4J2A2;A0A075B767;A0A075B759;Q9Y536;F5H284 P62937 PPIA;PPIAL4C;PPIAL4E;PPIAL4A;PPIAL4D Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C;Peptidyl-prolyl cis-trans isomerase A-like 4D 0 1375880600.0 180223600.0 1089740600.0 105916400.0 False True 273412377.3100296 895267875.747831 84981977.11519265 1.0 3.2744233620874548 0.3108197878650874 28.026503313965364 -6.7016678063955135 1.824839786413202 2.410016612415545 0.3193349311918439 0.4255047274690711 0.9597739129063341 0.3920792549906369 2.539474549617027 0.41940053284535206 1.076405346201588 1.9876146705453954e-07 6.7016678063955135 -2.090681681223701 IIPGFMCQGGDFTR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 IIPGFMCQGGDFTR 14 0 P62937;F8WE65;C9J5S7;P0DN26;A0A0H2UH34;A0A0B4J2A2;A0A075B767;A0A075B759;Q9Y536;F5H284 P62937 PPIA;PPIAL4C;PPIAL4E;PPIAL4A;PPIAL4D Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C;Peptidyl-prolyl cis-trans isomerase A-like 4D 0 1375255690.0 289319290.0 452062700.0 633873700.0 False True 396288450.0728277 432089075.142561 484165787.09863687 1.0 1.0903398145041927 1.2217509417941894 28.561975679305437 -6.9657634730687645 0.34471354911638247 0.9865028004005528 1.32998640217925 0.9999280094434672 0.0007724749591831243 0.07770300773722999 0.013952760116384272 0.0018295497327764192 0.011335875494055759 1.0820230859318674e-07 6.9657634730687645 0.3434836017786972 IIPGFMCQGGDFTR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IIPGFMCQGGDFTR 14 0 P62937;F8WE65;C9J5S7;P0DN26;A0A0H2UH34;A0A0B4J2A2;A0A075B767;A0A075B759;Q9Y536;F5H284 P62937 PPIA;PPIAL4C;PPIAL4E;PPIAL4A;PPIAL4D Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C;Peptidyl-prolyl cis-trans isomerase A-like 4D 0 459282400.0 270776400.0 49314600.0 139191400.0 False True 225162574.02843213 49048932.46161836 168295678.19168136 1.0 0.21783785637227954 0.7474407277402595 27.746391805208294 -9.983984473533823 6.362133877223281 1.000000177732413 0.4826392920658206 0.5599373674175266 0.21620946686078135 5.452206409458739e-07 8.678630899635003e-08 0.20934398785733366 0.06978130537034179 1.0375655091693895e-10 9.983984473533823 -0.5173608856665923 IIPGFMCQGGDFTR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IIPGFMCQGGDFTR 14 0 P62937;F8WE65;C9J5S7;P0DN26;A0A0H2UH34;A0A0B4J2A2;A0A075B767;A0A075B759;Q9Y536;F5H284 P62937 PPIA;PPIAL4C;PPIAL4E;PPIAL4A;PPIAL4D Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C;Peptidyl-prolyl cis-trans isomerase A-like 4D 0 476442600.0 180223600.0 168584600.0 127634400.0 False True 233303002.9382682 159202718.81222647 104406248.83953673 1.0 0.6823860679339451 0.44751352329212213 27.797629636057813 -7.667311223946789 0.16236253226116582 1.2874614628642227 1.7331391178425664e-12 0.9999663305487649 0.0013136426793029113 0.1345745990216403 0.01889895135578307 0.0523555109199351 0.0828289499680663 2.1512395617364124e-08 7.667311223946789 -1.2874614628624896 down IIQHCSNYSTQELLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIQHCSNYSTQELLR 15 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 6300800.0 1677600.0 2453400.0 2169800.0 False True 2297854.055435354 2345000.675691136 1657337.9284337275 1.0 1.0205176739333213 0.7212546525805036 21.131855739725083 -6.890475981676618 1.019585684414822 1.015896803919377 0.6952761516604864 0.9812003781110378 0.01871508107596744 0.11875689722365143 0.2196099573109901 0.013977463093951944 0.03490552215838335 1.2868384186740003e-07 6.890475981676618 -0.3206206522588906 IIQHLVPASFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIQHLVPASFR 11 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 6322800.0 2385500.0 2499300.0 1438000.0 False True 3127413.6012148634 2126414.1821950944 1289209.554270015 1.0 0.6799273947549104 0.41222867156720605 21.576538597977265 -7.354129686770609 0.19984330319478655 1.1866156348452794 9.62346203872112e-11 0.9999723138011531 0.001264252605841494 0.11449141026202568 0.013924476039744664 0.02238236684413073 0.052125266343151684 4.424562286443903e-08 7.354129686770609 -1.1866156347490449 down IIQHLVPASFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIQHLVPASFR 11 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 6032400.0 2452800.0 1010000.0 2569600.0 False True 2374937.2065948406 1413298.267080418 1896544.673652381 1.0 0.5950886883054857 0.7985662393034915 21.179457938375407 -10.108179141629918 5.293231375318562 1.0000057686699466 0.6968274638042434 0.7474720237776052 0.08306936234356746 5.65515961429653e-06 9.528356711558544e-07 0.08043309436159542 0.026810521411268377 7.79508505634212e-11 10.108179141629918 -0.3031783048657032 IIQHLVPASFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIQHLVPASFR 11 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 6972000.0 2385500.0 1608400.0 2978100.0 False True 3267483.8157135397 1537335.5697324618 2274734.115894774 1.0 0.47049523622406825 0.6961730322749975 21.639748659500157 -10.293440603272993 5.702593082108355 1.000038955357618 0.5833341342495303 0.8196583804558861 0.09213257443345839 4.563472263804458e-05 5.654252823722336e-06 0.0892152983535777 0.029735660535331245 5.088144034061817e-11 10.293440603272993 -0.4167048211080878 IIQHLVPASFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIQHLVPASFR 11 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 5934900.0 2452800.0 2048200.0 1433900.0 False True 2039611.8774639822 2037165.940064132 1733721.8603954832 1.0 0.998800782920086 0.8500253796085766 20.959863213809683 -6.908666132817095 0.9047693382945754 1.0048029491737895 0.8313372184985154 0.9904084187880846 0.006896474675857287 0.10530670376905255 0.1436003169546926 0.0056092614671461195 0.015344689297459841 1.2340531564076938e-07 6.908666132817095 -0.17346573067527415 IIQHLVPASFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIQHLVPASFR 11 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 5679700.0 1498700.0 3091400.0 1089600.0 False True 1940096.6937936116 2919360.872440999 891303.9802401176 1.0 1.5047501919775768 0.4594121432665742 20.887697126984083 -6.775399292773205 1.5537025873559074 1.2875098098888043 0.4522819852276702 0.7508055502547915 0.21307641115375164 0.2577893267608556 1.228775572479032 0.10805080828679742 0.25596228706298974 1.6772612256629613e-07 6.775399292773205 -0.835227824661134 down IIQK(ub)TPYPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIQKTPYPR 9 1 A0A2R8Y6S3;C9J167;P54278-2;P54278-3;P54278;P54278-4 A0A2R8Y6S3 PMS2 Mismatch repair endonuclease PMS2 1 5565550.0 1773700.0 2943900.0 847950.0 True False 1717394.8643742944 4119414.6222356916 625846.4570452735 1.0 2.398641516688438 0.3644161689474312 20.711790352042385 -6.7216723122066195 1.7531460516134518 1.8493933484742706 0.3672556066373636 0.520435494359381 0.5884371138555168 0.35209424499049957 2.1157658618220574 0.26640636145958807 0.6675061228050497 1.898137580933135e-07 6.7216723122066195 -1.482137741836907 IIQLLDDYPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIQLLDDYPK 10 0 P05388;F8VWS0;P05388-2;F8VU65;G3V210;F8VZS0;Q8NHW5;F8VQY6;F8VRK7;F8VS58 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 31762900.0 4496200.0 17833000.0 9433700.0 False True 5894561.741262733 15172385.912489558 8457591.218440222 1.0 2.5739633544391936 1.4348125593860412 22.49095312261217 -10.422397282625619 4.864035243184855 0.9984425234300824 2.004387956912814 0.5089672013261735 0.4650563646616773 0.007864380766465595 0.0009338918409979792 0.4508480774344039 0.15009629628177348 3.780965524206328e-11 10.422397282625619 1.0059454334827314 IIQLLDDYPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIQLLDDYPK 10 0 P05388;F8VWS0;P05388-2;F8VU65;G3V210;F8VZS0;Q8NHW5;F8VQY6;F8VRK7;F8VS58 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 31502700.0 16578000.0 6513000.0 8411700.0 False True 16051740.464338398 9113674.86484631 6208423.4244091455 1.0 0.5677686407336232 0.3867757168266075 23.936226399137638 -13.999999999171397 0.1192884178035642 3.061209521438728 0.09511087362936126 0.9996964405243708 0.004482158955824315 11.966545942090837 0.10620199124585551 5.852957179591143 0.2588097202395178 1.0000000019079289e-14 13.999999999171397 -2.9660986478093667 IIQLLDDYPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIQLLDDYPK 10 0 P05388;F8VWS0;P05388-2;F8VU65;G3V210;F8VZS0;Q8NHW5;F8VQY6;F8VRK7;F8VS58 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 49515200.0 4496200.0 25650000.0 19369000.0 False True 6158566.645236301 24516698.186792884 14794441.117076635 1.0 3.9809097796736093 2.4022539609147935 22.55416318413506 -10.22047754053459 6.66205224534762 0.9999859702581899 3.1915818702941916 0.7198629288920629 0.6444835392391179 0.00013444846321964435 1.5733163994781395e-05 0.6240224726554531 0.20800616786482637 6.018973891160286e-11 10.22047754053459 2.1915959000360017 IIQLLDDYPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIQLLDDYPK 10 0 P05388;F8VWS0;P05388-2;F8VU65;G3V210;F8VZS0;Q8NHW5;F8VQY6;F8VRK7;F8VS58 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 19979000.0 16578000.0 2213400.0 1187600.0 False True 13785341.529924111 2201475.974874498 1435921.6691580124 1.0 0.1596968758514768 0.10416293756966623 23.716631674571914 -13.562888136636873 0.39021201253472265 9.999985665440496 0.10005654043941005 0.9998138380702355 0.005591898194091871 17.849845272231917 0.2041714226937178 133.6684000388588 0.014612087426770318 2.7359733536525144e-14 13.562888136636873 -9.899929125001085 IIQLLDDYPK(ub)CFIVGADNVGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIQLLDDYPKCFIVGADNVGSK 22 1 P05388;F8VWS0;P05388-2;F8VU65;G3V210;F8VZS0;Q8NHW5;F8VQY6;F8VRK7;F8VS58 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 66054000.0 22715000.0 26929000.0 16410000.0 True False 29779584.972372893 22911298.16841988 14712050.615835158 1.0 0.7693625747193972 0.49403141882211643 24.827820311937064 -6.968774193758354 0.28596195570662253 1.0564634917801168 0.19847161820010412 0.9999711745336176 0.0011104378907365936 0.07670258589519394 0.01044747041824012 0.004917292951949164 0.02508726465285719 1.0745479655345508e-07 6.968774193758354 -0.8579918735800127 down IIQLLDDYPK(ub)CFIVGADNVGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIQLLDDYPKCFIVGADNVGSK 22 1 P05388;F8VWS0;P05388-2;F8VU65;G3V210;F8VZS0;Q8NHW5;F8VQY6;F8VRK7;F8VS58 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 231401600.0 114028900.0 77321700.0 40051000.0 True False 110409114.98576409 108196658.03733863 29560441.595754787 1.0 0.9799612835524428 0.2677355180282556 26.718284039928115 -6.912923022302657 0.8755985646660706 1.02006641343183 0.16969866672989284 0.9919784336941938 0.030502348187801065 0.10251697871095504 0.12851978255453145 0.02533926539903812 0.07144841240759885 1.2220162405361555e-07 6.912923022302657 -0.8503677467019372 down IIQLLDDYPK(ub)CFIVGADNVGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIQLLDDYPKCFIVGADNVGSK 22 1 P05388;F8VWS0;P05388-2;F8VU65;G3V210;F8VZS0;Q8NHW5;F8VQY6;F8VRK7;F8VS58 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 819860000.0 345152000.0 264644000.0 210064000.0 True False 523620817.99115795 217416210.52699035 168544758.32567823 1.0 0.415216895617511 0.32188322643910683 28.963947215846442 -13.999999999999998 0.2582771616603565 5.2427155648367 0.28720324127039626 0.9995588383311808 0.006303193005830074 14.341612366557566 0.16081758797686166 31.725025410892034 0.04117783050201472 1.0000000000000041e-14 13.999999999999998 -4.955512323566303 IIQLLDDYPK(ub)CFIVGADNVGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIQLLDDYPKCFIVGADNVGSK 22 1 P05388;F8VWS0;P05388-2;F8VU65;G3V210;F8VZS0;Q8NHW5;F8VQY6;F8VRK7;F8VS58 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 116107000.0 22715000.0 37163000.0 56229000.0 True False 31113349.349793743 35521015.7783931 42948868.272605754 1.0 1.141664800502379 1.3804000266814884 24.891030373459955 -6.963250693878214 0.38690669255552845 0.9848228479057032 1.5457775653076533 0.9998724121305737 0.001773087582232699 0.07855974661777748 0.01698522346512796 0.003088383811275252 0.02010887906528438 1.0883016963715566e-07 6.963250693878214 0.5609547174019501 IIQLLDDYPK(ub)CFIVGADNVGSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIQLLDDYPKCFIVGADNVGSK 22 1 P05388;F8VWS0;P05388-2;F8VU65;G3V210;F8VZS0;Q8NHW5;F8VQY6;F8VRK7;F8VS58 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 229401400.0 114028900.0 49798000.0 65574500.0 True False 94820082.68678755 49529728.28987094 79285824.76776864 1.0 0.5223548312384305 0.8361712257694172 26.49868931536239 -10.097665497695031 5.355523547130344 1.0000047171014215 0.6792630285037071 0.5820777622534727 0.1281150065875723 7.215835461837801e-06 1.215642703105018e-06 0.12404864572789498 0.04134894057596637 7.986095555142768e-11 10.097665497695031 -0.32074168859771435 IIQLLDDYPK(ub)CFIVGADNVGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIQLLDDYPKCFIVGADNVGSK 22 1 P05388;F8VWS0;P05388-2;F8VU65;G3V210;F8VZS0;Q8NHW5;F8VQY6;F8VRK7;F8VS58 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 793365600.0 345152000.0 275936000.0 172277600.0 True False 446806067.9630697 260579919.03276142 140924844.51745144 1.0 0.583205864281815 0.3154049477436807 28.73507353793889 -8.432501432316624 0.1998219115176344 1.3062876021854997 1.3631804576746204e-24 0.9997283163758397 0.004642919974401625 0.13059253498875706 0.04862751650249686 0.139036826097 0.12383731371283627 3.6940142605895458e-09 8.432501432316624 -1.3062876021854997 down IIQQVLQGLDYLHTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIQQVLQGLDYLHTK 15 0 H3BLV9;Q96SB4-4;Q96SB4;Q96SB4-3 H3BLV9 SRPK1 SRSF protein kinase 1 0 8818600.0 5252700.0 2251900.0 1314000.0 False True 6886340.567219159 1915925.2978374504 1178039.8847780256 1.0 0.27822110729721566 0.17106907119665468 22.715306101159737 -13.999999999999998 0.2686017109060399 6.529363591334528 0.13501665181878508 0.9995803307536026 0.00754112358045956 14.814945523048323 0.1640512566988297 44.69409669469169 0.04481565318367346 1.0000000000000041e-14 13.999999999999998 -6.394346939515743 IIQQVLQGLDYLHTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIQQVLQGLDYLHTK 15 0 H3BLV9;Q96SB4-4;Q96SB4;Q96SB4-3 H3BLV9 SRPK1 SRSF protein kinase 1 0 33630300.0 15349000.0 10170000.0 8111300.0 False True 14861754.39661781 14230934.035849385 5986707.196215969 1.0 0.9575541121233988 0.402826411771305 23.825101097039692 -6.922199952355556 0.8082456625317094 1.011296610619934 0.30868365189088726 0.9947704327516559 0.019674088012409743 0.09689471238896646 0.09903413849028174 0.017151746823089346 0.05250953354589734 1.1961896700346216e-07 6.922199952355556 -0.7026129587290466 down IIQQVLQGLDYLHTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIQQVLQGLDYLHTK 15 0 H3BLV9;Q96SB4-4;Q96SB4;Q96SB4-3 H3BLV9 SRPK1 SRSF protein kinase 1 0 23095600.0 7733200.0 7588500.0 7773900.0 False True 11731829.772648647 6234272.885778886 6237385.257578589 1.0 0.5313981711798568 0.5316634641358592 23.48392470725016 -9.994754459246773 6.149519421418654 1.0000003082506825 0.531530817657829 0.9999997587968755 0.00010830539586356755 4.577002855748715e-10 7.483427025066162e-11 0.00010486631654777112 3.4955416191813604e-05 1.0121515412198176e-10 9.994754459246773 -0.4684694905928536 IIQQVLQGLDYLHTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIQQVLQGLDYLHTK 15 0 H3BLV9;Q96SB4-4;Q96SB4;Q96SB4-3 H3BLV9 SRPK1 SRSF protein kinase 1 0 19575500.0 5252700.0 4836600.0 9486200.0 False True 7194765.138880109 4622903.019502625 7245754.934421617 1.0 0.6425370293910937 1.0070870688003366 22.778516162682628 -10.907431414626167 11.137146185765284 1.0163137710304933 0.8248120490957949 0.23542517284527376 0.1488269303773573 0.05610549195482223 0.0004663309755848318 0.13410984112488275 0.04803368523488963 1.237566615552443e-11 10.907431414626167 -0.1915017219346984 IIQQVLQGLDYLHTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIQQVLQGLDYLHTK 15 0 H3BLV9;Q96SB4-4;Q96SB4;Q96SB4-3 H3BLV9 SRPK1 SRSF protein kinase 1 0 30243100.0 15349000.0 5492900.0 9401200.0 False True 12763373.57599259 5463308.657444712 11366947.453762464 1.0 0.4280458160153663 0.8905911423875621 23.605506372473968 -10.03064256891062 7.14859184237363 1.0000000400689493 0.6593184792014722 0.4197229356230564 0.18883333875349892 1.204618102139968e-07 1.6388245784948734e-08 0.18283711312157655 0.06094569801675369 9.31874507111405e-11 10.03064256891062 -0.34068156086747703 IISAASEGGANVFTVSYFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IISAASEGGANVFTVSYFK 19 0 P14868;P14868-2 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 12645200.0 6281200.0 3290400.0 3073600.0 False True 6081806.744155053 4604273.879209317 2268531.9539764756 1.0 0.7570569195797409 0.37300296596182675 22.53606854325967 -6.964370334800263 0.3687016031408458 1.029972200113552 0.0867466214702018 0.9998995678696593 0.002586787592809595 0.0781753188186727 0.015617489892336753 0.005072332617218824 0.03264036736175169 1.085499593611752e-07 6.964370334800263 -0.9432255786433502 down IISAASEGGANVFTVSYFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IISAASEGGANVFTVSYFK 19 0 P14868;P14868-2 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 6797600.0 1398300.0 1244700.0 4154600.0 False True 1915289.2976366535 1189705.0383275263 3173369.0466728536 1.0 0.6211620561946164 1.6568614728796278 20.869130891888588 -6.807696275956266 1.4240522884086495 0.7929676481953357 1.6740673929310281 0.8537696027047178 0.16361803470720593 0.20995380031861907 0.8395564286592881 0.090352060777317 0.20924329479648265 1.5570541774714157e-07 6.807696275956266 0.8810997447356924 IISAASEGGANVFTVSYFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IISAASEGGANVFTVSYFK 19 0 P14868;P14868-2 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 13542300.0 6281200.0 3768600.0 3492500.0 False True 5223096.1043406585 3748297.803791465 4222765.602504518 1.0 0.7176390648214263 0.8084793996026963 22.316473818693947 -10.529635700567106 8.935803980992484 1.000014844193675 0.7630592322120613 0.9007061662484922 0.0370854113796185 1.096784854554048e-05 5.773666209821547e-07 0.03591004134656552 0.01196926505504278 2.953685829390717e-11 10.529635700567106 -0.23695561198161363 IISAASEGGANVFTVSYFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IISAASEGGANVFTVSYFK 19 0 P14868;P14868-2 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 10512000.0 0.0 10512000.0 0.0 False True 0.0 9926997.959209349 0.0 0.0 IISAHIHPVCSLCWSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IISAHIHPVCSLCWSR 16 0 Q15291-2;Q15291 Q15291-2 RBBP5 Retinoblastoma-binding protein 5 0 25695200.0 5124900.0 9851400.0 10718900.0 False True 7774847.980376438 8093340.700660494 8600304.716739224 1.0 1.0409644948798902 1.1061701448627963 22.890383036194276 -6.964251892080953 0.37067097197622817 0.9950236252935007 1.1543831064534544 0.9998968616817011 0.000443957193330974 0.0782157928140972 0.015760940918115893 0.0008585924724425519 0.005535884012857528 1.085795676253035e-07 6.964251892080953 0.1593594811599537 IISAHIHPVCSLCWSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IISAHIHPVCSLCWSR 16 0 Q15291-2;Q15291 Q15291-2 RBBP5 Retinoblastoma-binding protein 5 0 22883400.0 6084100.0 10225800.0 6573500.0 False True 8333556.186620297 9773990.343801416 5020974.685482118 1.0 1.1728474765063404 0.6025008499424772 22.99050083898171 -6.825420091864795 1.3483454727266062 1.0926874178612787 0.5885497278156235 0.8963832769315274 0.07686476513197409 0.18653002843183406 0.6648287171406109 0.04478029210798573 0.10308866011256505 1.4947890511969273e-07 6.825420091864795 -0.5041376900456551 IISAHIHPVCSLCWSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IISAHIHPVCSLCWSR 16 0 Q15291-2;Q15291 Q15291-2 RBBP5 Retinoblastoma-binding protein 5 0 19250400.0 5124900.0 7925400.0 6200100.0 False True 6634284.07688189 7484344.523013482 5071745.418398269 1.0 1.1281314511529208 0.7644751656130448 22.661509358286725 -6.8114696347451 1.408206203889339 1.0697102527413234 0.757888097709126 0.8636677674830783 0.0556080026312584 0.20479998474668246 0.8001381569112631 0.031046640319694178 0.07177534906049014 1.5435843447821879e-07 6.8114696347451 -0.31182215503219735 IISDNLTYCK(ub)CLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IISDNLTYCKCLQK 14 1 Q9Y2X3;H7BZ72 Q9Y2X3 NOP58 Nucleolar protein 58 1 16633800.0 3986800.0 6772100.0 5874900.0 True False 5226733.408226125 5761729.077439042 5267021.704020108 1.0 1.1023575582353045 1.0077081214302177 22.317478145220687 -10.887739411831149 3.787452784140363 0.9793252509464462 1.0550328398328708 0.3107066731568219 0.03864047076940126 0.009024742344577542 0.0002674944580760175 0.050053161152815766 0.01247115831491063 1.2949726261867268e-11 10.887739411831149 0.07570758888642459 IISDNLTYCK(ub)CLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IISDNLTYCKCLQK 14 1 Q9Y2X3;H7BZ72 Q9Y2X3 NOP58 Nucleolar protein 58 1 12826600.0 3986800.0 2906100.0 5933700.0 True False 5460827.699218925 2777698.8928124253 4532282.268387501 1.0 0.5086589516841423 0.8299625108178681 22.380688206743578 -10.096125758342387 5.332140090675588 1.0000050099787077 0.6693107312507506 0.5854695455145189 0.13117162873719673 7.812407574550802e-06 1.3242882375768173e-06 0.12700830764073617 0.042335461132709015 8.014459556517222e-11 10.096125758342387 -0.3306942787279571 IISDNLTYCK(ub)CLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IISDNLTYCKCLQK 14 1 Q9Y2X3;H7BZ72 Q9Y2X3 NOP58 Nucleolar protein 58 1 43180300.0 11775000.0 5987300.0 25418000.0 True False 15242969.619950484 5654101.491740309 20792184.810704205 1.0 0.3709317562596228 1.3640507938486428 23.86164065881584 -6.73552026672743 1.7028965926353108 0.6237778268048486 1.364105143398624 0.584736005414057 0.26435164163048214 0.32599034320591064 1.854290098032022 0.12289245375728959 0.30308609905381356 1.83856815348981e-07 6.73552026672743 0.7403273165937754 IISIFSGTEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IISIFSGTEK 10 0 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 0 16332000.0 4344000.0 5029400.0 6958600.0 False True 5695026.067355834 4279033.124447649 6238590.823604535 1.0 0.7513632200869589 1.095445525590206 22.44127101479732 -6.712845436703126 1.7850968163766647 0.8475901417607136 1.0947058264911635 0.4785995410295175 0.10472872787713054 0.36937985505415055 2.2961858265839945 0.04665771243600871 0.11812377960803834 1.9371112497684303e-07 6.712845436703126 0.24711568473044998 IISIFSGTEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IISIFSGTEK 10 0 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 0 10627000.0 4464500.0 2442100.0 3720400.0 False True 4322776.891243742 3417243.265383256 2745915.6303924057 1.0 0.7905203880184649 0.6352202992374089 22.04352694657059 -6.9744090653170305 0.1101682146727003 1.325497063323259 0.09627968322165556 0.9999996149116205 9.257275302115648e-05 0.07489627105627475 0.0032565975933105916 0.012306316672874339 0.023750232052436496 1.0606960087922928e-07 6.9744090653170305 -1.2292173801016035 IISIFSGTEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IISIFSGTEK 10 0 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 0 19143400.0 4344000.0 6353800.0 8445600.0 False True 5950094.192185953 6073068.106793154 6450923.222591884 1.0 1.0206675576276925 1.0841716137979214 22.50448107632021 -6.950909484294166 0.5487446550292464 0.9991151510367745 1.1087010575132736 0.9992708600902971 0.0009670950453730987 0.08312215984307095 0.03446346015887579 0.0010513614436493653 0.005266990042320804 1.1196712211547761e-07 6.950909484294166 0.10958590647649913 IISIFSGTEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IISIFSGTEK 10 0 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 0 9965600.0 4464500.0 3811700.0 1689400.0 False True 3712429.560884677 3791165.615536791 2042645.7290969566 1.0 1.021208767293985 0.5502180433586978 21.823932222004867 -6.89635725084537 0.9840267823335541 1.0215868956908343 0.5042823981736263 0.9846646689239131 0.02689726293566813 0.11413595656546638 0.19293479720603518 0.020633145275645467 0.05276608302408207 1.2695293601139608e-07 6.89635725084537 -0.517304497517208 IISIFSGTEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IISIFSGTEK 10 0 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 0 13512500.0 3696100.0 6065900.0 3750500.0 False True 4784674.311023265 5728327.332645353 3067947.4833797337 1.0 1.197224086798977 0.6412029918758698 22.189989294273076 -6.81079482616866 1.4109955533107563 1.1073831971426458 0.6312784024657285 0.8619570859109417 0.08551658023776891 0.20570578289787364 0.8069897745558782 0.047652032251507395 0.11019977125157425 1.545984636880918e-07 6.81079482616866 -0.47610479467691724 IISK(ub)IENHEGVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IISKIENHEGVR 12 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 43962100.0 11405200.0 17558100.0 14998800.0 True False 14952327.648113914 14938499.920937734 13446868.05464888 1.0 0.9990752124016006 0.8993160376836089 23.833866752313746 -6.90892892132533 0.9029944663923205 1.0031943423197338 0.8867147483143478 0.9905111316060212 0.004602307983441837 0.1051306209788884 0.142639378990559 0.0037481301155299187 0.010271383512814456 1.233306665473425e-07 6.90892892132533 -0.11647959400538599 IISK(ub)IENHEGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IISKIENHEGVR 12 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 93696200.0 19155200.0 29525000.0 45016000.0 True False 18547128.66102636 41314486.47084099 33224959.14894756 1.0 2.227540835345385 1.791380205323327 24.14469252021473 -10.148214746061964 4.8723146714542525 0.9999285629445909 2.0094605203384317 0.8771812061331776 0.17806183158821584 0.00013818527270097913 2.4157570131955057e-05 0.1724197143882834 0.057469209026024586 7.108619260704806e-11 10.148214746061964 1.0095319573938408 IISK(ub)IENHEGVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IISKIENHEGVR 12 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 151318000.0 31030000.0 23920000.0 96368000.0 True False 47074778.596866496 19651289.112186965 77320822.56040522 1.0 0.4174483597782665 1.6425105941029756 25.488450973751966 -6.777385995233353 1.5459582634074722 0.6690254349622282 1.6514476048036717 0.758063415337253 0.24609717051808597 0.2546577381793432 1.2019518453404607 0.12540073411458386 0.29655814221623233 1.669606030750566e-07 6.777385995233353 0.9824221698414435 IISK(ub)IENHEGVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IISKIENHEGVR 12 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 39302600.0 11405200.0 12863300.0 15034100.0 True False 15622010.653940912 12294956.872755265 11483355.217008715 1.0 0.7870278125596885 0.7350753671462801 23.897076813836637 -13.999999997820774 0.19815808552067568 2.175686966345334 0.7007160836351988 0.9994869441679273 0.0025962381647541225 12.495129647291071 0.14115707380974918 5.689423134870691 0.03354090076425468 1.0000000050178526e-14 13.999999997820774 -1.4749708827101355 IISK(ub)IENHEGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IISKIENHEGVR 12 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 66931400.0 19155200.0 41461000.0 6315200.0 True False 15928397.519242514 41237641.36363582 7635679.121814313 1.0 2.588938486361741 0.4793752235647013 23.925097795649005 -6.705137776041356 1.812234451455852 1.9815893244867768 0.4849006228466509 0.4422888258094959 0.670090663706532 0.3848402356150778 2.4605019505930286 0.2945800359571889 0.7529023139559055 1.9717971018809365e-07 6.705137776041356 -1.4966887016401258 IISK(ub)IENHEGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IISKIENHEGVR 12 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 68093900.0 31030000.0 22982900.0 14081000.0 True False 40168946.6927443 21703881.411407195 11518402.483260911 1.0 0.540314924795565 0.2867489299972477 25.259577295844416 -9.152713772582633 0.18832718948135072 1.4482149519006442 4.920269153989256e-10 0.9996309812756485 0.0056709133726308755 0.5937235946136662 0.0655491571973965 0.30489027627353904 0.147957275602295 7.035358415534597e-10 9.152713772582633 -1.4482149514086173 IISMLNYFLQHLVGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IISMLNYFLQHLVGPK 16 0 Q14139-2;Q14139;B7Z7P0 Q14139-2 UBE4A Ubiquitin conjugation factor E4 A 0 11546800.0 9380200.0 2166600.0 0.0 False True 12142853.811385104 2046026.805405535 0.0 1.0 0.1684963713791223 0.0 23.533604187591425 -9.787839301428823 0.4391798957986841 1.293336647472063 2.07613597342774e-21 0.9983555173474947 0.01772682646708338 1.2181177269908126 0.21446357350702286 0.5478581447441425 0.03956228525891293 1.6298990197877982e-10 9.787839301428823 -1.293336647472063 IISNASCTTNCLAPLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IISNASCTTNCLAPLAK 17 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 311715000.0 21355000.0 176420000.0 113940000.0 False True 27996611.80211417 150098823.67977402 102150581.78965615 1.0 5.361321032012855 3.6486765795688973 24.738748904522463 -9.445097951032245 9.216940201552992 0.9999667552121284 4.504998805790895 0.8481269238505755 0.6991841701461866 0.0 0.0 0.6769821616079366 0.2256607205359788 3.5884099230952285e-10 9.445097951032245 3.5050320505787664 IISNASCTTNCLAPLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IISNASCTTNCLAPLAK 17 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 84617200.0 66848000.0 10440000.0 7329200.0 False True 64725946.830745265 14608746.443880789 5409462.648713037 1.0 0.2257015487480136 0.08357487087610291 25.9478408286711 -13.999999999999934 0.23841257875754898 6.085978255031121 0.0197799181252512 0.9995223654940313 0.00880115003461455 13.567932748677121 0.1545485511127029 32.82314355937016 0.07010231414119662 1.0000000000001513e-14 13.999999999999934 -6.06619833690587 IISNASCTTNCLAPLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IISNASCTTNCLAPLAK 17 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 1429150100.0 25085000.0 1384809100.0 19256000.0 False True 38055778.959149025 1137679096.542117 15450043.159795392 1.0 29.895041637785386 0.40598415227238527 25.181612214987542 -3.3754073956132196 20.535320644596815 9.999999999955868 6.144972784159648 0.0 13.770231441480057 0.0 0.0 4.349337645286586 0.0 0.0004213011109941892 3.3754073956132196 -3.8550272157962198 IISNASCTTNCLAPLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IISNASCTTNCLAPLAK 17 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 442055000.0 21355000.0 251770000.0 168930000.0 False True 29250520.59717568 240645968.9079469 129032213.22255929 1.0 8.227066185317153 4.411279204207331 24.801958966045355 -9.716600852022415 8.246163752790762 0.9999668873744424 6.319172694762256 0.7215219941053137 1.5577885119296715 0.0 0.0 1.5083222408512011 0.5027740802837336 1.9204329463303855e-10 9.716600852022415 5.319205807387814 IISNASCTTNCLAPLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IISNASCTTNCLAPLAK 17 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 88688000.0 25085000.0 34127000.0 29476000.0 False True 32473026.999274544 32227802.44995597 24111670.44930039 1.0 0.9924483618566248 0.7425137930578215 24.95273853707999 -6.913348944352341 0.8726091288278911 1.006943136607085 0.7077876304646824 0.9921253894268219 0.010616728433589151 0.10224512005674997 0.12705965183842483 0.008838625125565758 0.02500397626692928 1.2208183700998923e-07 6.913348944352341 -0.2991555061424025 IISNLFLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IISNLFLGR 9 0 A0A0D9SFK2;Q92614-2;Q92614-3;Q92614-4;Q92614;Q92614-5 A0A0D9SFK2 MYO18A Unconventional myosin-XVIIIa 0 6210500.0 2494900.0 2930700.0 784900.0 False True 3270838.0606459714 2493450.983779127 703686.077292444 1.0 0.7623278614064692 0.21513938148117 21.641228902610234 -7.061423082934081 0.5078288463822512 1.0097092931812743 6.789502972700572e-12 0.9995220342740707 0.0071843898280006995 0.07430058444504822 0.028937632832082914 0.008426123272739191 0.041038211790895604 8.681143137454628e-08 7.061423082934081 -1.0097092931744849 down IISNLFLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IISNLFLGR 9 0 A0A0D9SFK2;Q92614-2;Q92614-3;Q92614-4;Q92614;Q92614-5 A0A0D9SFK2 MYO18A Unconventional myosin-XVIIIa 0 5865400.0 2820200.0 1043800.0 2001400.0 False True 2730674.2946994305 1460594.7833450923 1477173.2992869988 1.0 0.534884290733715 0.5409555076394029 21.380825814059218 -10.293041698380915 6.255213364265615 1.000017479999153 0.5379198991868928 0.9998705433514417 0.002478563922783252 6.042314037223292e-07 6.829116924763676e-08 0.0023999498253389293 0.0007999530662873851 5.0928197047474744e-11 10.293041698380915 -0.46209758081226027 IISNLFLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IISNLFLGR 9 0 A0A0D9SFK2;Q92614-2;Q92614-3;Q92614-4;Q92614;Q92614-5 A0A0D9SFK2 MYO18A Unconventional myosin-XVIIIa 0 8383000.0 2494900.0 2713800.0 3174300.0 False True 3417331.952137377 2593895.342663487 2424595.716760614 1.0 0.7590410820468084 0.709499618626205 21.704438964133125 -13.999999999999998 0.2223500408031829 2.4692113734044936 0.6835892190465617 0.999500354516958 0.0028362992841654004 13.064598132182887 0.1493619592714812 8.438588669232695 0.02699865410459159 1.0000000000000041e-14 13.999999999999998 -1.7856221543579318 IISNLFLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IISNLFLGR 9 0 A0A0D9SFK2;Q92614-2;Q92614-3;Q92614-4;Q92614;Q92614-5 A0A0D9SFK2 MYO18A Unconventional myosin-XVIIIa 0 6299500.0 2820200.0 1622600.0 1856700.0 False True 2345121.2560436716 1613858.7317391154 2244927.3855891568 1.0 0.6881770942888343 0.9572756119981845 21.161231089493494 -10.149725166058463 7.0764119002424195 1.0000001705097359 0.8227263538005977 0.36654123147951057 0.1098590098212018 2.955451683557905e-07 3.5614453093133654e-08 0.1063706303091818 0.03545684295569597 7.083939344651499e-11 10.149725166058463 -0.17727381670913822 IISPK(ub)NNPPTIVQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IISPKNNPPTIVQDK 15 1 Q6ZVM7-3;Q6ZVM7-5;Q6ZVM7;K7ENB0;B7Z2U2 Q6ZVM7-3 TOM1L2 TOM1-like protein 2 1 22406900.0 8606800.0 9528100.0 4272000.0 True False 11283598.148369752 8106544.6202429 3829974.4199175956 1.0 0.7184361330179176 0.33942846683803146 23.427723856332598 -6.97875099004745 0.3238931985359564 1.0499719142618977 1.8227813067161116e-14 0.9999489722163905 0.0019333702752664707 0.07578431233653532 0.012498708950977159 0.005635951898437225 0.032632933094900084 1.0501443737823053e-07 6.97875099004745 -1.0499719142618795 down IISPK(ub)NNPPTIVQDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IISPKNNPPTIVQDK 15 1 Q6ZVM7-3;Q6ZVM7-5;Q6ZVM7;K7ENB0;B7Z2U2 Q6ZVM7-3 TOM1L2 TOM1-like protein 2 1 26226000.0 10365000.0 7782800.0 8078200.0 True False 10035968.74851415 10890512.626765823 5962277.079194681 1.0 1.085148120691208 0.5940908375265129 23.258676547600768 -6.862191177353449 1.1747058013231952 1.0464896273074886 0.5693071962783741 0.9562434787350282 0.04481814316240411 0.14455630984611528 0.37782318184229 0.029731108733852655 0.0695771882779476 1.3734372519263737e-07 6.862191177353449 -0.4771824310291145 IISPK(ub)NNPPTIVQDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IISPKNNPPTIVQDK 15 1 Q6ZVM7-3;Q6ZVM7-5;Q6ZVM7;K7ENB0;B7Z2U2 Q6ZVM7-3 TOM1L2 TOM1-like protein 2 1 37579000.0 12298000.0 14892000.0 10389000.0 True False 18656965.104230236 12234406.248272942 8335609.596339548 1.0 0.6557554339584921 0.4467827189347935 24.153210988816372 -9.161796889682444 0.12709756192321978 1.583581474258106 5.695261571577905e-10 0.9999037486535609 0.0022377275394853935 0.6126286977094257 0.043832982630296 0.3248152048564116 0.19551559813276614 6.88974439740519e-10 9.161796889682444 -1.5835814736885798 IISPK(ub)NNPPTIVQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IISPKNNPPTIVQDK 15 1 Q6ZVM7-3;Q6ZVM7-5;Q6ZVM7;K7ENB0;B7Z2U2 Q6ZVM7-3 TOM1L2 TOM1-like protein 2 1 18152600.0 8606800.0 5199100.0 4346700.0 True False 11788966.550024418 4969386.570875425 3320098.983096542 1.0 0.42152860047474916 0.2816276531965955 23.49093391785549 -13.999999999999904 0.19937903252524836 4.208079816994821 0.1902116757878428 0.9994869138887815 0.007043658729189216 12.518694788434775 0.1415864303732442 15.65758193001077 0.08949585732651752 1.0000000000002209e-14 13.999999999999904 -4.017868141206978 IISPK(ub)NNPPTIVQDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IISPKNNPPTIVQDK 15 1 Q6ZVM7-3;Q6ZVM7-5;Q6ZVM7;K7ENB0;B7Z2U2 Q6ZVM7-3 TOM1L2 TOM1-like protein 2 1 32731900.0 10365000.0 16937000.0 5429900.0 True False 8618956.74735574 16845757.01926872 6565266.984979027 1.0 1.9545007027024388 0.7617240899826099 23.039081823035044 -6.693608228383368 1.8536694234298337 1.5963733858510072 0.7656643442661466 0.3873627096856582 0.40339504600977116 0.40894149731552704 2.7270931724207266 0.17391718423710972 0.4508309934916252 2.0248449423353452e-07 6.693608228383368 -0.8307090415848606 IISPK(ub)NNPPTIVQDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IISPKNNPPTIVQDK 15 1 Q6ZVM7-3;Q6ZVM7-5;Q6ZVM7;K7ENB0;B7Z2U2 Q6ZVM7-3 TOM1L2 TOM1-like protein 2 1 42430000.0 12298000.0 18201000.0 11931000.0 True False 15920003.429821765 17188098.35003515 9759680.422397994 1.0 1.0796541863702087 0.6130451205880965 23.92433731090882 -6.8629434639215265 1.1708536825491318 1.043599070985892 0.5891545384732086 0.9571143079250479 0.04220425897483041 0.14379578281213795 0.3729379990808308 0.028079609306304255 0.06577531601928624 1.3710602379789759e-07 6.8629434639215265 -0.45444453251268335 IISRFLINCK(ub)WNEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IISRFLINCKWNEK 14 2 D6RBJ0 D6RBJ0 GUF1 1 90802100.0 23080100.0 38907000.0 28815000.0 True False 30258234.608006366 33102227.258298136 25833500.212997552 1.0 1.0939906999577313 0.8537675957526609 24.85082448135733 -6.8005623322508315 1.453456942387746 1.051821085729602 0.8503988590445264 0.8338617971532483 0.04028751161160497 0.21994499532382863 0.9172343296097549 0.02180473470707986 0.05069610108356702 1.5828423724580817e-07 6.8005623322508315 -0.2014222266850756 IISRFLINCK(ub)WNEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IISRFLINCKWNEK 14 2 D6RBJ0 D6RBJ0 GUF1 1 85124900.0 23080100.0 34373400.0 27671400.0 True False 31613436.6862503 32854669.530366667 21135985.230371937 1.0 1.039262825375016 0.6685760058337681 24.91403454288022 -6.880712085017139 1.0757860565167465 1.0245731247488767 0.6419407025812585 0.9742567270412285 0.026676506465845934 0.12700271731878868 0.2684719691207114 0.01908901026077407 0.04624806821694345 1.3160970479327546e-07 6.880712085017139 -0.3826324221676183 IISRFLINCK(ub)WNEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IISRFLINCKWNEK 14 2 D6RBJ0 D6RBJ0 GUF1 1 94675900.0 9801900.0 32114000.0 52760000.0 True False 12688752.77433484 30326827.669525176 43158221.36331555 1.0 2.3900558399140963 3.4012973639623896 23.597046932388793 -7.8521845853945536 0.18760281523137354 1.9223171838915352e-10 4.912967734500883 0.9999016690054245 0.009761338228934961 0.1253505793413026 0.028778791979256972 0.2633562689956102 0.3837374044657696 1.4054500477603005e-08 7.8521845853945536 4.912967734308651 IISSDRDLLAVVFYGTEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IISSDRDLLAVVFYGTEK 18 1 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 7173800.0 2719900.0 2693100.0 1760800.0 False True 2633558.263297986 3768468.874330968 1299593.6571322817 1.0 1.430941903526274 0.49347442782785067 21.328581946507807 -6.78171914477076 1.5292672802025118 1.2434619362079045 0.48565508544823943 0.7734130608726814 0.18237614423314186 0.24790237664455927 1.1452505624785407 0.09392129343284489 0.22128968969138577 1.6530304559756836e-07 6.78171914477076 -0.757806850759665 down IISSIEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IISSIEQK 8 0 P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 0 18838450.0 570750.0 8248700.0 10019000.0 False True 748258.7771508632 7018026.113180762 8982329.98903427 1.0 9.379143055164985 12.004309556162095 19.513177771217663 -8.97029377959242 0.4871030183648324 3.149882373027508e-16 12.109739088551143 0.9967237046201894 0.26860748705548737 0.4502128920052981 0.18794739333572633 1.632910954944785 0.5447557789020613 1.070794718415839e-09 8.97029377959242 12.109739088551143 IISSIEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IISSIEQK 8 0 P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 0 15051200.0 5884500.0 1753200.0 7413500.0 False True 5697699.768512445 2453261.9028172223 5471681.949767247 1.0 0.43057058154851147 0.9603317429966644 22.441948172402242 -10.632582059964626 9.607515278095434 1.0000898842241457 0.6954511622725884 0.30586820572710094 0.21627408851535895 0.0004165120622643939 1.59284643758086e-05 0.20946746331454832 0.0698021619196812 2.330332757187135e-11 10.632582059964626 -0.3046387219515573 IISSIEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IISSIEQK 8 0 P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 0 15250150.0 570750.0 7412300.0 7267100.0 False True 781771.6989387985 7084800.07680174 5550760.6506225085 1.0 9.062492395694127 7.1002322777318305 19.576387832740554 -9.424319557691433 8.11630257258438 0.9999999984295738 8.0813623367152 0.9455467517909113 0.801089338611484 0.0 0.0 0.7756514168130811 0.258550472271027 3.7642671897387364e-10 9.424319557691433 7.081362338285627 IISSIEQK(ub)EENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IISSIEQKEENK 12 1 P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 1 10004600.0 3420000.0 3504700.0 3079900.0 True False 4483653.119327114 2981812.421213603 2761221.4924869435 1.0 0.6650408365357888 0.6158419081495169 22.09624323676622 -13.999999999999998 0.27012501614249357 3.5870727554177924 0.5995307811577807 0.9995835961996613 0.0034829577270936267 14.889004257557586 0.16452683635766366 21.15445803133822 0.020420400058623386 1.0000000000000041e-14 13.999999999999998 -2.9875419742600116 IISSIEQK(ub)EENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IISSIEQKEENK 12 1 P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 1 16580800.0 4971400.0 4754700.0 6854700.0 True False 4813585.628206776 6653276.505432942 5059248.43340791 1.0 1.3821872133001845 1.0510353038619678 22.198680523795204 -10.431912930221987 6.394183939030827 0.9999495073916074 1.216611258581076 0.36325510799200356 0.13519220091199596 9.733454488063353e-05 8.647794406379434e-06 0.13092972686621243 0.04363309522244062 3.699023324277847e-11 10.431912930221987 0.21666175118946862 IISSIEQK(ub)EENK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IISSIEQKEENK 12 1 P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 1 9932400.0 3420000.0 3958100.0 2554300.0 True False 4684466.42202486 3783218.0543136406 1951026.947459798 1.0 0.8076091732723628 0.4164886182739393 22.15945329828911 -6.959723971076449 0.4393067198187495 1.014086323112158 0.19477978719044067 0.9997598239546992 0.0037624917871780573 0.07979986774996259 0.021496766558024235 0.005152285908075844 0.032411070252264265 1.0971753173625703e-07 6.959723971076449 -0.8193065359217173 down IISSIEQK(ub)EENK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IISSIEQKEENK 12 1 P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 1 14999900.0 4971400.0 7251800.0 2776700.0 True False 4133939.370362212 7212733.114030399 3357295.131989773 1.0 1.744760255977926 0.8121297462801468 21.97908579922948 -6.6940459567112 1.8523943828460991 1.4651427264586299 0.8152169546364205 0.3892961387640477 0.31472787909518524 0.4080123388328352 2.717551566288496 0.1357751982483019 0.3517293830958778 2.0228051156562495e-07 6.6940459567112 -0.6499257718222093 IISSIEQK(ub)EENKGGEDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IISSIEQKEENKGGEDK 17 2 P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 1 18883600.0 5777700.0 7066800.0 6039100.0 True False 5594290.076053084 9888610.09287515 4457278.540883445 1.0 1.7676255536344692 0.7967549913014468 22.415523631939358 -6.695927669822004 1.8453409433738255 1.4785322767992186 0.7998410998745225 0.3984370369357578 0.3242679061416524 0.4039795494607006 2.671527989198595 0.1403416813841204 0.3627540712429722 2.0140596562954962e-07 6.695927669822004 -0.6786911769246962 IISSIEQK(ub)EENKGGEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IISSIEQKEENKGGEDK 17 2 P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 1 11432100.0 3613500.0 4276700.0 3541900.0 True False 4949508.601165735 4087741.252844332 2705376.167720256 1.0 0.8258883016955592 0.546594901781375 22.238853867475477 -6.964118442107994 0.37287822317662045 1.0207891434273668 0.3419282420960436 0.9998937951801135 0.001924605424162463 0.07826145678250954 0.015922993535631088 0.003665981663415285 0.0236841340257276 1.0861293707260089e-07 6.964118442107994 -0.6788609013313232 IISYAQGFMLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IISYAQGFMLLR 12 0 P52209-2;P52209;K7ELN9 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 10345680.0 3273800.0 6207400.0 864480.0 False True 4291983.5035243 5281280.116255687 775031.9022777064 1.0 1.2304986987762279 0.1805766265507079 22.033213100351176 -6.849161675478576 1.239092105841409 1.1229240983753872 0.1392720246418791 0.9390769539450713 0.11120630078489335 0.1583866594736325 0.4683746571766019 0.07024148972311743 0.16246204935869762 1.4152668183090658e-07 6.849161675478576 -0.9836520737335082 down IISYAQGFMLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IISYAQGFMLLR 12 0 P52209-2;P52209;K7ELN9 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 16081800.0 7764400.0 5640000.0 2677400.0 False True 7517923.3720176825 7892081.412211459 1976108.6197216997 1.0 1.049768802058614 0.26285298771159804 22.84190277981371 -6.891820578831406 1.0115266796581956 1.0404549240190288 0.1927003198637627 0.982039031349464 0.0482197619905843 0.11767936107480462 0.2133072608778872 0.03623204362168244 0.09094180888513205 1.2828604645541224e-07 6.891820578831406 -0.8477546041552662 down IISYAQGFMLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IISYAQGFMLLR 12 0 P52209-2;P52209;K7ELN9 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 47576000.0 16023000.0 13698000.0 17855000.0 False True 24308062.438207924 11253484.877037508 14325951.423875477 1.0 0.4629527715606425 0.5893497871454224 24.534931566949176 -9.99137782970998 7.197398857316609 1.0000000260725583 0.5261512793531411 0.9493386624574789 0.05160136553222155 2.1571988318792386e-08 3.051500430867583e-09 0.0499628099427175 0.01665426911232115 1.0200516678610999e-10 9.99137782970998 -0.47384874671941724 IISYAQGFMLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 IISYAQGFMLLR 12 0 P52209-2;P52209;K7ELN9 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 31464600.0 4488600.0 11732700.0 15243300.0 False True 6148156.719854032 11214310.519149488 11643146.485617949 1.0 1.8240118185236722 1.893762149559255 22.551722509901737 -11.110533449077725 0.4347749853024037 4.369167995505092e-21 1.8956735372600177 0.9996585975534674 0.007499535776498284 3.0351423181825448 0.21295548113166654 3.002295021452783 0.016286198998468497 7.75294228404243e-12 11.110533449077725 1.8956735372600177 IISYAQGFMLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IISYAQGFMLLR 12 0 P52209-2;P52209;K7ELN9 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 26574500.0 10177500.0 6969900.0 9427100.0 False True 8463042.189697353 6932351.7652831655 11398263.024014406 1.0 0.8191323651585238 1.3468280989890729 23.01274492806564 -6.814190273411078 1.396855695939638 0.9019043627307771 1.3569706125596106 0.8704795835139097 0.07879904569508683 0.20114566415656385 0.7727018750316789 0.04434671328640949 0.10240198889867334 1.5339447825651346e-07 6.814190273411078 0.4550662498288335 IISYAQGFMLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IISYAQGFMLLR 12 0 P52209-2;P52209;K7ELN9 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 60358000.0 16023000.0 22134000.0 22201000.0 False True 20742089.360549208 20902223.442650262 18160645.801496737 1.0 1.0077202483953052 0.8755456350524506 24.306057889041625 -6.893037814385378 1.004217859521549 1.0065933706949406 0.8634760917363881 0.9827732016700295 0.007949876352551408 0.11671379781787687 0.2077171171180493 0.006006500690726088 0.015148026826322205 1.2792699122021642e-07 6.893037814385378 -0.14311727895855253 IITEGFEAAK(ub)EK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IITEGFEAAKEK 12 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 200764000.0 64878000.0 75592000.0 60294000.0 True False 85055686.27944577 64313968.25530818 54055355.26088761 1.0 0.7561395489069147 0.635529000181031 26.341904352691994 -13.999999999999998 0.09191000786074767 2.2387046778151913 0.3430931947809267 0.9998333789610014 0.0019569226810761567 12.14669657137236 0.08854738763548126 2.921100367677147 0.2623070324323545 1.0000000000000041e-14 13.999999999999998 -1.8956114830342647 IITEGFEAAK(ub)EK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IITEGFEAAKEK 12 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 257549000.0 87949000.0 60690000.0 108910000.0 True False 85157107.13584875 84923833.49416898 80383203.77003452 1.0 0.997260667376739 0.9439400476791849 26.343623605175377 -6.917554786453627 0.8426672993739616 1.0012833282486122 0.935807402787859 0.9934741658945221 0.0020846276836096965 0.0996318986887906 0.11322848826058907 0.0017732407541062648 0.005193613641890072 1.209052650760544e-07 6.917554786453627 -0.0654759254607532 IITEGFEAAK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IITEGFEAAKEK 12 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 815260000.0 203040000.0 314160000.0 298060000.0 True False 308026524.2123033 258095693.4567165 239148310.3556614 1.0 0.8379008727145439 0.7763886923933587 28.198479346064353 -13.999999999999998 0.13434801390960038 1.7713479991806136 0.6948195991265825 0.9996263929777403 0.0018230434042750174 11.932375872464204 0.1143908592750881 2.421798868968938 0.07267970759865429 1.0000000000000041e-14 13.999999999999998 -1.076528400054031 IITEGFEAAK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IITEGFEAAKEK 12 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 764250000.0 203040000.0 321460000.0 239750000.0 True False 262839282.51675156 303570468.4139497 196117960.04273885 1.0 1.1549661279972572 0.7461516336708143 27.969605668156802 -6.803972991356973 1.4394779635610417 1.0850749573582466 0.7399280383668362 0.8435776847953529 0.06664903988133765 0.21512752610267494 0.8795634138097012 0.036416761536063706 0.08450154618185338 1.5704604677601828e-07 6.803972991356973 -0.34514691899141037 IITEGFEAAKEK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 IITEGFEAAKEK 12 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 21594400.0 7515600.0 9263800.0 4815000.0 True False 9853024.381173939 7881677.15000957 4316789.988741396 1.0 0.7999246571508541 0.43811826924831704 23.232135196431525 -6.961966135612531 0.40677941509761006 1.0184611537612642 0.20622498600062908 0.9998363060391642 0.0029750921825405984 0.07900614707637067 0.018590443226522174 0.004655743129415983 0.030240371338588874 1.0915254455188856e-07 6.961966135612531 -0.8122361677606351 down IITEGFEAAKEK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 IITEGFEAAKEK 12 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 103353000.0 25343000.0 36899000.0 41111000.0 True False 38447183.821475595 30314085.156797092 32985392.83040863 1.0 0.7884604838043934 0.8579404146626689 25.19637459177219 -10.342768651008337 7.881843570218764 1.000001167579537 0.8232004492335312 0.896194578856195 0.028365062994438386 5.819853424860764e-07 4.8496936112856526e-08 0.027464535434620782 0.009154784715965354 4.541834961040372e-11 10.342768651008337 -0.17680071834600586 IITEGFEAAKEK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IITEGFEAAKEK 12 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 81442500.0 7515600.0 4866800.0 69060100.0 True False 10294320.42145323 4651768.683644581 52749526.71740533 1.0 0.4518771995818544 5.124138802545528 23.295345257954416 -6.877649538672741 1.092771232625722 0.6697387237709735 5.44075698035419 0.971741906673873 0.35055403355727077 0.12973502329520958 0.28501116097902773 0.24760564061736626 0.5953832209152916 1.3254106664659604e-07 6.877649538672741 4.771018256583217 up IITEGFEAAKEK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IITEGFEAAKEK 12 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 98762000.0 25343000.0 40767000.0 32652000.0 True False 32807013.085214917 38498280.612926915 26709671.037812375 1.0 1.1734771621216828 0.8141451636707999 24.96750091386464 -6.77540021787629 1.5535228927413158 1.0988121246271692 0.8116849699711798 0.750885680203772 0.07323277335520113 0.2577788339808098 1.228413351798556 0.03713930827245321 0.08798587925035119 1.6772576528847062e-07 6.77540021787629 -0.28712715465598937 IITFTK(ub)NNQFQALLQYADPVSAQHAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IITFTKNNQFQALLQYADPVSAQHAK 26 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68;K7EKJ7 P26599 PTBP1 Polypyrimidine tract-binding protein 1 1 22600700.0 5496600.0 6971100.0 10133000.0 True False 8338744.055286372 5727052.739547103 8130208.108548332 1.0 0.6868003984264777 0.9749919238010624 22.99139867701609 -10.424634388769736 8.210668972197196 1.000003191661988 0.830896161432357 0.3146340804653467 0.1176536975603472 6.874056797736451e-06 4.817315709148814e-07 0.11391985317708359 0.03797256760591241 3.7615393658911246e-11 10.424634388769736 -0.16910703022963103 IITFTK(ub)NNQFQALLQYADPVSAQHAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IITFTKNNQFQALLQYADPVSAQHAK 26 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68;K7EKJ7 P26599 PTBP1 Polypyrimidine tract-binding protein 1 1 23432200.0 5496600.0 4909600.0 13026000.0 True False 7115457.054184276 4636376.444114751 10655401.658046784 1.0 0.6515922180133614 1.497500663261094 22.76252499910854 -6.794862102583249 1.476758942275983 0.8064933591253954 1.5077518106258079 0.816697245913862 0.1486172449431277 0.22819245241026198 0.9829132099999823 0.07919085656182231 0.18477794735302097 1.603754534853698e-07 6.794862102583249 0.7012584515004124 IITITGTQDQIQNAQYLLQNSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IITITGTQDQIQNAQYLLQNSVK 23 0 P61978;P61978-2;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 32630600.0 16738500.0 12828000.0 3064100.0 False True 21944335.595864568 10914112.403152352 2747056.324922638 1.0 0.49735442458367835 0.12518293447172416 24.3873452548893 -8.121899519439923 0.37434578552719144 1.0820192700952338 2.4637401423557674e-23 0.9978299845080553 0.016698488099811615 0.09463667660551855 0.08728547895434896 0.0593070202243532 0.08493969859968127 7.552669498202367e-09 8.121899519439923 -1.0820192700952338 IITITGTQDQIQNAQYLLQNSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IITITGTQDQIQNAQYLLQNSVK 23 0 P61978;P61978-2;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 213705300.0 99761900.0 49810400.0 64133000.0 False True 96595013.09140328 69699952.47780445 47334643.35124073 1.0 0.7215688496449677 0.49003195751368867 26.525445373210307 -7.02627656772808 0.16665316249506892 1.2176487834897873 3.951177787416823e-12 0.9999978252771469 0.0003074000248558134 0.07206202666250418 0.005173604313154513 0.010254869346776198 0.02656697496221123 9.412899726511207e-08 7.02627656772808 -1.217648783485836 down IITITGTQDQIQNAQYLLQNSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IITITGTQDQIQNAQYLLQNSVK 23 0 P61978;P61978-2;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 196422000.0 36245000.0 123092000.0 37085000.0 False True 54986314.8644352 101125270.87781425 29755133.495067105 1.0 1.8390988944636737 0.5411370732595236 25.712569265868595 -6.732183328580818 1.7153907388888192 1.5037315154600446 0.5416116310647136 0.5693360742572833 0.35267942571981276 0.33214475297646445 1.915728811291553 0.16286699406950597 0.40312953709010585 1.8527493578661652e-07 6.732183328580818 -0.962119884395331 IITITGTQDQIQNAQYLLQNSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IITITGTQDQIQNAQYLLQNSVK 23 0 P61978;P61978-2;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 28766000.0 16738500.0 4354100.0 7673400.0 False True 22927175.79095411 4161721.46491676 5861100.958633679 1.0 0.18151915015013592 0.25563990140234233 24.450555316412192 -10.205005684903405 5.156978586843355 1.0000621035071309 0.21857952577584971 0.9932972876550135 0.030259669987967808 2.160783519623252e-05 3.3310238769251723e-06 0.029301111532074705 0.009766266493565857 6.2372667086318e-11 10.205005684903405 -0.7814825777312812 IITITGTQDQIQNAQYLLQNSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IITITGTQDQIQNAQYLLQNSVK 23 0 P61978;P61978-2;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 191234500.0 99761900.0 33773600.0 57699000.0 False True 82956440.05152242 33591654.9132653 69763594.12996654 1.0 0.40493124936897323 0.8409665854349332 26.305850648644583 -9.785873020091753 6.110764584626765 1.0000000143600518 0.6229489174014574 0.4992492132980374 0.17801068053264466 3.490630776811408e-08 6.724752125779835e-09 0.17235810799166817 0.057452700095555934 1.6372951671580332e-10 9.785873020091753 -0.3770510969585944 IITITGTQDQIQNAQYLLQNSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IITITGTQDQIQNAQYLLQNSVK 23 0 P61978;P61978-2;P61978-3 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 83781000.0 36245000.0 27988000.0 19548000.0 False True 46919866.99576267 26430443.19657069 15990464.579417992 1.0 0.5633102753457853 0.34080370647389285 25.483695587961044 -10.359928633997741 0.14349979836704033 1.808777852215686 3.7934172489248615e-10 0.9997399959434753 0.004415082938435263 2.0925784832953607 0.07282383441390004 0.8153949720374944 0.2109607037256658 4.365875691626606e-11 10.359928633997741 -1.8087778518363444 IITK(ub)GTQTYSVLEGDPSENYSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IITKGTQTYSVLEGDPSENYSK 22 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 14837600.0 3833600.0 4823800.0 6180200.0 True False 5025886.724635205 4104107.8430251256 5540732.188664505 1.0 0.8165937809358437 1.1024387321556017 22.26094672489438 -6.733425797908848 1.7108085302119032 0.8900508594090133 1.1023760691032045 0.5750667752471685 0.07708085016186202 0.3298413356888057 1.892822859872186 0.035682893771431884 0.08820099852208488 1.8474564181214207e-07 6.733425797908848 0.21232520969419122 IITK(ub)GTQTYSVLEGDPSENYSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IITKGTQTYSVLEGDPSENYSK 22 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 19177900.0 3845900.0 6527600.0 8804400.0 True False 3723814.0096392264 9134104.720984302 6498263.513661666 1.0 2.452889617295693 1.745055874659872 21.828349586884684 -10.220849859723108 6.843170324877977 0.9999948816524016 2.0989727459777825 0.7626975200829876 0.28897191536371225 2.256549598133775e-05 2.5692814005456772e-06 0.27979715291055923 0.09326528464377636 6.01381605644077e-11 10.220849859723108 1.098977864325381 IITK(ub)GTQTYSVLEGDPSENYSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IITKGTQTYSVLEGDPSENYSK 22 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 72821000.0 15144000.0 12553000.0 45124000.0 True False 22974555.174700122 10312819.072963333 36205221.6214482 1.0 0.4488800324769701 1.5758834652571578 24.453533593039587 -6.773729100384204 1.5601134897271336 0.6853996747128094 1.5831452014817884 0.7446350878502626 0.23252259942207124 0.2604456410475521 1.2515163302256296 0.11744179161943501 0.278622517687646 1.6837239891110488e-07 6.773729100384204 0.897745526768979 IITK(ub)GTQTYSVLEGDPSENYSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IITKGTQTYSVLEGDPSENYSK 22 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 17374600.0 3833600.0 5878000.0 7663000.0 True False 5250985.519144585 5618290.524053355 5853157.224438949 1.0 1.0699497272596945 1.1146778453490118 22.324156786417273 IITK(ub)GTQTYSVLEGDPSENYSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IITKGTQTYSVLEGDPSENYSK 22 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 17145800.0 3845900.0 5556700.0 7743200.0 True False 3198036.2522581243 5526764.954181408 9362267.319488328 1.0 1.728174579096461 2.9275050627952255 21.60875486231896 -6.963656625255509 0.38040354620370553 0.9179904520648274 3.7801278028433396 0.999882719849773 0.008606258940261124 0.07841982107661058 0.016485783680397697 0.015601690890586524 0.10132275807491663 1.0872849452333829e-07 6.963656625255509 2.862137350778512 IITK(ub)GTQTYSVLEGDPSENYSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IITKGTQTYSVLEGDPSENYSK 22 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 80594000.0 15144000.0 12532000.0 52918000.0 True False 19604206.532868788 11834583.183486653 43287466.98453249 1.0 0.6036757041732123 2.2080703400036055 24.224659915132037 -6.8413475842109435 1.2761546516683493 0.7891950703069991 2.2622547425245334 0.9267477120571092 0.18468298207967176 0.16722480457889416 0.5284397281212282 0.1134539856799653 0.26147311080736146 1.4409616274676931e-07 6.8413475842109435 1.4730596722175342 up IITLAGPTNAIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IITLAGPTNAIFK 13 0 Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;F8VXH9;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 103184200.0 38304000.0 60324000.0 4556200.0 False True 50216914.936463624 51323894.34111029 4084768.130156499 1.0 1.0220439548316989 0.08134247464872553 25.58167006393646 -6.922737638959321 0.9792702006840605 1.035602146245057 1.0177034212790394e-13 0.9872801338848419 0.04943787687204712 0.10383318430452104 0.17576055707717497 0.03872068521593961 0.09454880774398765 1.1947096208870533e-07 6.922737638959321 -1.0356021462449554 down IITLAGPTNAIFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IITLAGPTNAIFK 13 0 Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;F8VXH9;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 124730000.0 63779000.0 30708000.0 30243000.0 False True 61754370.55585957 42969864.54010444 22321451.02944775 1.0 0.6958190028224203 0.36145540515641733 25.880037908700483 -7.080455890626694 0.2746138967296055 1.08378185962526 7.308125113099444e-14 0.9999738413373668 0.0013337700695918932 0.07459231883251685 0.010571544659929375 0.0072695394109776644 0.031077432185561252 8.308911043579502e-08 7.080455890626694 -1.083781859625187 down IITLAGPTNAIFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IITLAGPTNAIFK 13 0 Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;F8VXH9;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 120933000.0 20266000.0 79591000.0 21076000.0 False True 30745003.643058207 65387364.20267859 16910319.36206105 1.0 2.1267639113596966 0.5500184536774048 24.873848641978764 -6.714855060612233 1.7777491103603758 1.6892603107727089 0.5531525374671864 0.4881234923365205 0.47447198036160565 0.36543506358240296 2.2541374170236272 0.21215109410647262 0.5358444031237749 1.9281683036003937e-07 6.714855060612233 -1.1361077733055225 IITLAGPTNAIFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IITLAGPTNAIFK 13 0 Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;F8VXH9;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 191863000.0 38304000.0 61022000.0 92537000.0 False True 52466023.926678374 58325846.26723099 70681666.45933814 1.0 1.1116879439681147 1.3471893078483754 25.644880125459352 -6.958997913086542 0.44933441752104186 0.9923536976928579 1.4758491748650229 0.9997312053066801 0.0023725493921844206 0.08006105800391004 0.022468817120140216 0.0031446136566738603 0.019481786832694425 1.0990111204933756e-07 6.958997913086542 0.483495477172165 IITLAGPTNAIFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IITLAGPTNAIFK 13 0 Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;F8VXH9;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 120897000.0 63779000.0 26132000.0 30986000.0 False True 53035064.38877012 25991221.729204144 37465029.33692335 1.0 0.49007617938722897 0.706419983999423 25.66044318413476 -10.271897684701973 5.64090209750656 1.000031390922707 0.5982480816933196 0.8213636785910816 0.08832198838540127 3.4870384626615676e-05 4.500957880483481e-06 0.08552406461653506 0.02850579917671167 5.346903120793474e-11 10.271897684701973 -0.40178330922938743 IITLAGPTNAIFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IITLAGPTNAIFK 13 0 Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;F8VXH9;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 76895000.0 20266000.0 33449000.0 23180000.0 False True 26234736.50258317 31587533.745965913 18961477.846885026 1.0 1.2040347248334546 0.7227622753145627 24.644974964071213 -6.791501940443882 1.490180794710742 1.113810510465878 0.7174185277495638 0.8062152733704337 0.08682470466513603 0.23310880831793587 1.0225737483228707 0.0458559104651269 0.10725041812240027 1.6162110047996577e-07 6.791501940443882 -0.39639198271631415 IITLTGPTNAIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IITLTGPTNAIFK 13 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 200987000.0 73277000.0 105440000.0 22270000.0 False True 96066856.61547744 89708763.00190096 19965714.028924383 1.0 0.9338159502915168 0.20783144918377275 26.517535446471282 -6.92473089944648 0.7888415079425314 1.0134560809296234 0.07699475977911342 0.9953974319658396 0.024345235020276277 0.09546754218777757 0.09176989999107292 0.021519885427528834 0.06769161476746877 1.1892388836176767e-07 6.92473089944648 -0.93646132115051 down IITLTGPTNAIFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IITLTGPTNAIFK 13 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 289508000.0 141480000.0 67303000.0 80725000.0 False True 136988794.8422365 94177438.88050844 59580700.80191027 1.0 0.6874827900264991 0.4349311990847612 27.02948265019227 -7.367866075377762 0.18366508335994125 1.215069311935661 5.935466446185553e-15 0.9999796749851471 0.0010419529107858461 0.11673908869088181 0.012980685085963607 0.024864726364035753 0.0535139782480474 4.286806934994665e-08 7.367866075377762 -1.215069311935655 down IITLTGPTNAIFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IITLTGPTNAIFK 13 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 177835000.0 41339000.0 100740000.0 35756000.0 False True 62714285.285719104 82762159.9147875 28688810.927588455 1.0 1.3196699848803597 0.4574525691696161 25.902290766943075 -6.806316055826304 1.4299400312072126 1.1749894037500377 0.4436027627129656 0.8500023333523463 0.13783732871565346 0.21186301928812218 0.8544603461256811 0.07580991952596244 0.1756764761368955 1.5620104829126263e-07 6.806316055826304 -0.7313866410370721 down IITLTGPTNAIFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IITLTGPTNAIFK 13 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 381337000.0 73277000.0 120320000.0 187740000.0 False True 100369487.13646655 115003864.55496746 143399678.62666956 1.0 1.1458050433056752 1.4287178575665866 26.580745507994173 -6.9606328420734345 0.4264232042266664 0.988326516783123 1.5969817939881212 0.999792949001458 0.0025610214660276237 0.0794758587283704 0.020301909381083394 0.0036772158210277277 0.02351068471557524 1.0948816015622944e-07 6.9606328420734345 0.6086552772049982 IITLTGPTNAIFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IITLTGPTNAIFK 13 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 265870000.0 141480000.0 63253000.0 61137000.0 False True 117646888.62671392 62912243.53426248 73920464.03445058 1.0 0.5347548436565884 0.6283248532733875 26.809887925626548 -9.93995546237129 5.6747952257170615 1.0000004037554766 0.5815398484645399 0.9638558117136785 0.03819979646641932 1.951203004791096e-07 3.651785667052323e-08 0.03698682915731914 0.012328931295002588 1.1482713726172889e-10 9.93995546237129 -0.41846055529093673 IITLTGPTNAIFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IITLTGPTNAIFK 13 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 142586000.0 41339000.0 61433000.0 39814000.0 False True 53514150.41351454 58014199.54605289 32568260.52613805 1.0 1.0840908264032143 0.6085915645577215 25.673417089035524 -6.861223002216764 1.1796177633254266 1.045776435362886 0.585030270004659 0.9551056188686395 0.04390128273908057 0.14554247299074569 0.3841494753838421 0.029013580610677336 0.0678187683159867 1.376502478728579e-07 6.861223002216764 -0.460746165358227 IITTAVDK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 IITTAVDKR 9 1 Q9NWZ5-4;Q9NWZ5 Q9NWZ5-4 UCKL1 Uridine-cytidine kinase-like 1 1 2724550.0 721020.0 722430.0 1281100.0 True False 945264.2023676129 614646.2600100838 1148544.0611789408 1.0 0.6502375298573384 1.2150508379584997 19.850358094958654 -6.739198950516675 1.6895264786876047 0.7916995681357125 1.2153305861092931 0.601366690704888 0.1469586099024343 0.3192766771876018 1.7891637011151107 0.06881862075516636 0.16903014375872602 1.823060366146076e-07 6.739198950516675 0.4236310179735806 IITTAVDK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 IITTAVDKR 9 1 Q9NWZ5-4;Q9NWZ5 Q9NWZ5-4 UCKL1 Uridine-cytidine kinase-like 1 1 15517600.0 1524900.0 2948700.0 11044000.0 True False 2313384.7851228407 2422481.446701745 8861148.559242837 1.0 1.04715889128367 3.8303824838081617 21.141573818618124 -6.910579536019581 0.8917931082726638 0.9153973259090254 4.194544563343317 0.9911380967727754 0.12457048405345954 0.10403572033203383 0.1367030671930617 0.10228064915603387 0.28348229927226254 1.22862815691332e-07 6.910579536019581 3.279147237434292 up IITTAVDK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IITTAVDKR 9 1 Q9NWZ5-4;Q9NWZ5 Q9NWZ5-4 UCKL1 Uridine-cytidine kinase-like 1 1 13588100.0 1524900.0 2805700.0 9257500.0 True False 1974013.1102728262 2649560.328591484 7572729.989971455 1.0 1.3422202288338863 3.8362105857163415 20.912700140710573 -6.931873849677467 0.7312454696685029 0.9645871654447842 4.373537542767356 0.996893918321057 0.07045026616345537 0.09167639573335368 0.07299821751768977 0.0649144575378933 0.2233831681722556 1.1698391470164472e-07 6.931873849677467 3.4089503773225722 up IITVPVFHLFHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IITVPVFHLFHK 12 0 Q9NR09 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 0 3606900.0 1022300.0 1447800.0 1136800.0 False True 850087.7455689125 1440000.414034202 1374499.6240306732 1.0 1.6939432682569686 1.616891469375086 19.697252237526712 -10.201719550944874 4.8440719374931485 0.9999109621849042 1.6554173688176754 0.9897408250686537 0.031456265176477816 3.025294322044535e-05 4.985574232946578e-06 0.030461504821658922 0.010152465929375324 6.284640633853168e-11 10.201719550944874 0.6555064066327713 IIVACIETLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIVACIETLR 10 0 Q14008-2;Q14008;Q14008-3;E9PQH5 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 16458700.0 3288600.0 7439500.0 5730600.0 False True 4989046.628864165 6111863.099921199 4597944.398188797 1.0 1.2250563192897357 0.9216078221412797 22.250332722518323 -6.708092654315283 1.8022595309398313 1.1386295983572547 0.9223675518181447 0.455949487932777 0.09486623849722595 0.3789076959808619 2.397980388585369 0.04190977842908101 0.10670733028035023 1.9584268094520165e-07 6.708092654315283 -0.21626204653911008 IIVACIETLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIVACIETLR 10 0 Q14008-2;Q14008;Q14008-3;E9PQH5 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 12335300.0 3288600.0 5383500.0 3663200.0 False True 4257157.527997384 5083903.492523162 2996535.187606093 1.0 1.194201402952239 0.7038816787725725 22.021459044610772 -6.799252800851057 1.4590651423926682 1.1072506379912592 0.6972449254631248 0.829945296929542 0.08313866326904858 0.22182342640071898 0.932397654233111 0.044829288474468494 0.10429939586452432 1.5876223318052432e-07 6.799252800851057 -0.41000571252813445 IIVDELK(ub)QEVISTSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIVDELKQEVISTSSK 16 1 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6RF23;H0Y9P0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 20127000.0 4498900.0 7004100.0 8624000.0 True False 5898101.467409567 5959115.581767959 7731671.207249385 1.0 1.0103447040874984 1.31087456700624 22.491819211199818 -6.91420870300775 0.866598390961124 0.9918870972614271 1.3534211108625671 0.9924148007524213 0.012556314619776004 0.10170032699368789 0.12416353138955476 0.01049889609629011 0.029900109194522285 1.218403946360329e-07 6.91420870300775 0.36153401360114 IIVDELK(ub)QEVISTSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIVDELKQEVISTSSK 16 1 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6RF23;H0Y9P0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 56970200.0 11413600.0 10177800.0 35378800.0 True False 11051281.515488785 14241848.616525825 26112030.93875034 1.0 1.2887056217476083 2.3628056983394505 23.397710339605627 -6.946540975670107 0.5956093719510299 0.9877754378601348 2.7183064455870083 0.9989011233856394 0.01943717240341872 0.08490516407859473 0.04194501498117953 0.020036536813978285 0.09013789112156234 1.1309906753664716e-07 6.946540975670107 1.7305310077268734 up IIVDELK(ub)QEVISTSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIVDELKQEVISTSSK 16 1 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6RF23;H0Y9P0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 445164400.0 15118400.0 52542000.0 377504000.0 True False 22935718.103089467 43165469.58748023 302890168.9341186 1.0 1.8820195379740823 13.206046899107946 24.451092742224283 -6.922441396567829 0.8064035527369925 0.7714407435705826 15.138847877047509 0.9948328206710664 0.3995096138133861 0.09675664020607133 0.0983233223414583 0.348745366211749 1.0703534259613567 1.1955248381813426e-07 6.922441396567829 14.367407133476926 up IIVDELK(ub)QEVISTSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIVDELKQEVISTSSK 16 1 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6RF23;H0Y9P0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 26840400.0 4498900.0 6461000.0 15880500.0 True False 6162264.908201055 6175531.656330166 12129852.969163872 1.0 1.002152901299562 1.968408231366498 22.55502927272271 -6.907385625638763 0.9133431380262987 0.9675528857098268 2.0865461078368854 0.9898971970119566 0.045834336063403786 0.10617289226325755 0.14832891825570377 0.0370466428660958 0.10050597984737135 1.237697102841416e-07 6.907385625638763 1.1189932221270587 IIVDELK(ub)QEVISTSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIVDELKQEVISTSSK 16 1 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6RF23;H0Y9P0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 38134600.0 11413600.0 10994600.0 15726400.0 True False 9490914.108212216 10935369.907542782 19014717.52934199 1.0 1.152193538247356 2.003465347230263 23.178115615039903 -6.937338525909742 0.6838803504581351 0.9898629690065951 2.216098757975042 0.9977940459287782 0.020738959883772366 0.0890021203841326 0.06029894295483955 0.019801776253903246 0.0741672004677461 1.1552114215059655e-07 6.937338525909742 1.226235788968447 up IIVDELK(ub)QEVISTSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIVDELKQEVISTSSK 16 1 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6RF23;H0Y9P0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 548375100.0 15118400.0 35246700.0 498010000.0 True False 19571066.828217376 33285190.160660602 407377290.0141162 1.0 1.7007345819631219 20.815282763572377 24.222219064316732 -6.914660110596003 0.8634104946029503 0.4917905404839867 23.548409609489074 0.9925642915920719 0.7916229997148836 0.1014160560703641 0.12265290878207957 0.6634344219763606 1.8962407666528887 1.2171381898878855e-07 6.914660110596003 23.056619069005087 up IIVDTYGGWGAHGGGAFSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIVDTYGGWGAHGGGAFSGK 20 0 P31153;P31153-2;Q00266 P31153 MAT2A;MAT1A S-adenosylmethionine synthase isoform type-2;S-adenosylmethionine synthase isoform type-1 0 20833500.0 5893300.0 7791700.0 7148500.0 False True 7726173.370798391 6629208.731808726 6408841.793253965 1.0 0.8580196707550313 0.8294975385197318 22.881322620487698 -13.999999999999925 0.22563187537605406 1.8785394446401542 0.8150406159955723 0.9995041440943385 0.001660449230302338 13.158993327979235 0.150434364319507 5.166656905946267 0.015218569096763205 1.0000000000001718e-14 13.999999999999925 -1.063498828644582 IIVDTYGGWGAHGGGAFSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIVDTYGGWGAHGGGAFSGK 20 0 P31153;P31153-2;Q00266 P31153 MAT2A;MAT1A S-adenosylmethionine synthase isoform type-2;S-adenosylmethionine synthase isoform type-1 0 20959300.0 5946100.0 4584200.0 10429000.0 False True 5757344.310230583 6414694.96628719 7697332.036706371 1.0 1.1141760194693446 1.3369587820253348 22.456972062594538 -6.960524992035286 0.42797221263153007 0.9909580304082896 1.468691571271207 0.9997891718808546 0.002031683119823799 0.07951414028926322 0.020442447677208563 0.002899575477161372 0.01850673535643002 1.0951535315329461e-07 6.960524992035286 0.4777335408629174 IIVDTYGGWGAHGGGAFSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIVDTYGGWGAHGGGAFSGK 20 0 P31153;P31153-2;Q00266 P31153 MAT2A;MAT1A S-adenosylmethionine synthase isoform type-2;S-adenosylmethionine synthase isoform type-1 0 28622400.0 3724700.0 16830000.0 8067700.0 False True 5650642.212044745 13826555.006609814 6473115.558801467 1.0 2.446899748339672 1.145553959336438 22.429983412689083 -6.620730099274649 2.1136306235287283 1.959535471353262 1.150491289410717 0.08539538383569933 0.6220934649258338 0.5834415573769415 4.95372498501547 0.24172983359231923 0.6899072541457821 2.394803591154884e-07 6.620730099274649 -0.8090441819425449 IIVDTYGGWGAHGGGAFSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIVDTYGGWGAHGGGAFSGK 20 0 P31153;P31153-2;Q00266 P31153 MAT2A;MAT1A S-adenosylmethionine synthase isoform type-2;S-adenosylmethionine synthase isoform type-1 0 24447200.0 5893300.0 5919900.0 12634000.0 False True 8072212.270444189 5658339.2435085755 9650109.405397585 1.0 0.7009651200856261 1.195472700926207 22.94453268201059 -6.743024224305153 1.6759922434757137 0.8226981052564702 1.195936833101231 0.6182933032755344 0.12563592442517846 0.3123681342395215 1.724010111667545 0.0592799803010396 0.14496692208018475 1.8070733273169138e-07 6.743024224305153 0.37323872784476075 IIVDTYGGWGAHGGGAFSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIVDTYGGWGAHGGGAFSGK 20 0 P31153;P31153-2;Q00266 P31153 MAT2A;MAT1A S-adenosylmethionine synthase isoform type-2;S-adenosylmethionine synthase isoform type-1 0 14403400.0 5946100.0 3990300.0 4467000.0 False True 4944445.606893582 3968803.461887466 5401029.046925602 1.0 0.8026791631308737 1.0923426964987637 22.237377338028814 -6.72327548530138 1.7474662811363963 0.880377803359493 1.0919796382478593 0.5280201697453845 0.0830012586476297 0.3489596662380599 2.084209781868192 0.03768854051561915 0.09425203711395466 1.8911436320759383e-07 6.72327548530138 0.21160183488836626 IIVENLFYPVTLDVLHQIFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIVENLFYPVTLDVLHQIFSK 21 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68;K7EKJ7 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 22499882450.0 10084322400.0 6531032000.0 5884528050.0 False True 15298654343.519909 5365518312.414101 4721448501.637236 1.0 0.3507183175680276 0.30861854877040945 33.83268570915699 -13.85293616577094 0.3899908069226285 9.99999999204437 0.30551383596737014 0.9998203049434546 0.004242213428056016 22.48388258983844 0.20441538104386608 169.79814138943254 0.01108491408909551 1.4030199105268406e-14 13.85293616577094 -9.694486156077 IIVENLFYPVTLDVLHQIFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIVENLFYPVTLDVLHQIFSK 21 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68;K7EKJ7 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 15642312270.0 10084322400.0 1244600000.0 4313389870.0 False True 13054354138.512613 1175336915.9086726 3528397172.7775297 1.0 0.0900340915711199 0.27028508153981706 33.60381203124943 -10.103056400637442 7.212380052297728 1.0000002783756203 0.18015958655547393 0.9650142130103517 0.07358715850913977 3.293474376505535e-07 4.0997244840850035e-08 0.0712504837371898 0.02375015328338528 7.887576771630018e-11 10.103056400637442 -0.8198406918201464 IIVLGLLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIVLGLLPR 9 0 P68402;J3KNE3 P68402 PAFAH1B2 Platelet-activating factor acetylhydrolase IB subunit beta 0 52389400.0 23094000.0 22341000.0 6954400.0 False True 22360893.611016467 31261877.806775913 5132834.012472023 1.0 1.398060307901748 0.2295451202336228 24.414474508135985 -6.814769574738557 1.3942030578834088 1.215762966085019 0.20676085789546586 0.871934237757233 0.17358211336201862 0.20038577376417066 0.7667020991094606 0.09786619157236211 0.2259560674087261 1.5319000320771166e-07 6.814769574738557 -1.0090021081895533 down IIVLGLLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIVLGLLPR 9 0 P68402;J3KNE3 P68402 PAFAH1B2 Platelet-activating factor acetylhydrolase IB subunit beta 0 58830000.0 21674000.0 20820000.0 16336000.0 False True 32881042.581646275 17104508.332597535 13107182.439676845 1.0 0.5201936127823704 0.3986242956600496 24.97075270847214 -13.999999999999998 0.1927824785662586 3.5972593292547446 0.3138095147593793 0.9994881177234397 0.005873963631471474 12.39737690545142 0.1392392036565478 12.107145120584354 0.08179176941153424 1.0000000000000041e-14 13.999999999999998 -3.2834498144953654 IIVLGLLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIVLGLLPR 9 0 P68402;J3KNE3 P68402 PAFAH1B2 Platelet-activating factor acetylhydrolase IB subunit beta 0 44681600.0 23094000.0 9445600.0 12142000.0 False True 19203684.237668443 9394714.677995188 14680836.061735088 1.0 0.4892141821186193 0.7644801841168742 24.19487978357026 -10.073000445624698 5.2461016405224585 1.0000051139071837 0.6268471831171679 0.7101643356933987 0.11237687474064056 6.7216430261672485e-06 1.1877588978938482e-06 0.10880993233957909 0.03626948036381885 8.452779778295894e-11 10.073000445624698 -0.3731579307900158 IIVLGLLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIVLGLLPR 9 0 P68402;J3KNE3 P68402 PAFAH1B2 Platelet-activating factor acetylhydrolase IB subunit beta 0 65777000.0 21674000.0 26617000.0 17486000.0 False True 28057420.258412484 25135740.551776547 14303727.421511302 1.0 0.8958678424556895 0.5098019450744977 24.74187903056459 -6.946621225359633 0.5947834868081696 1.0044032317169604 0.3816800044402966 0.9989087424158704 0.006965822029413828 0.0848715541288862 0.04180102622478393 0.007186592303226292 0.03239004703185396 1.1307817082501374e-07 6.946621225359633 -0.6227232272766638 IIWQFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIWQFIK 7 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 74741000.0 17690000.0 22522000.0 34529000.0 False True 23191761.310203694 19161805.3900684 30956270.305555917 1.0 0.8262332961161414 1.3347960032658697 24.46710905457078 -6.814472077587129 1.3954984724620743 0.9057855522239567 1.3446466199904998 0.8712233236997368 0.07574008866976291 0.20076150468170895 0.7696401374216751 0.04266456317060739 0.09851463116652533 1.5329497622552664e-07 6.814472077587129 0.4388610677665431 IIWQFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIWQFIK 7 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 63435900.0 26347000.0 9583900.0 27505000.0 False True 25510628.906618673 13410801.249378245 20300615.36768706 1.0 0.5256946545092365 0.7957708703300573 24.60459512996007 -10.181063371546049 5.526740000180786 1.0000101039712213 0.6607327624196129 0.6778371460643564 0.11025815340392173 1.3727327601702438e-05 2.034268969904607e-06 0.10676017466800082 0.035585665993063224 6.590777166764811e-11 10.181063371546049 -0.3392773415516084 IIWQFIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIWQFIK 7 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 22732900.0 8043600.0 7257600.0 7431700.0 False True 12202729.265928304 5962424.576112382 5962821.237570172 1.0 0.4886140179115741 0.4886465238738999 23.540700521676435 -9.942770601724428 5.277049454336973 1.0000013479792185 0.4886302708893971 0.9999999963958578 1.3270515232638074e-05 2.1045956197623997e-10 4.212468913422085e-11 1.2849149953961812e-05 4.283038689294494e-06 1.1408522369134592e-10 9.942770601724428 -0.5113710770898214 IIWQFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIWQFIK 7 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 81037000.0 17690000.0 29858000.0 33489000.0 False True 24230471.054274783 28538774.832797702 25579587.927604854 1.0 1.1778052010987563 1.0556785243798246 24.530319116093672 -10.275946399058197 4.6499791339869425 0.9999498383072847 1.1167418627395647 0.5492138345815782 0.04985800699178192 2.593982170565669e-05 4.039120649804381e-06 0.0482955373866743 0.01609160256267939 5.297288193745888e-11 10.275946399058197 0.11679202443227998 IIWQFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIWQFIK 7 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 53744000.0 26347000.0 13433000.0 13964000.0 False True 21908697.87000308 13360633.762758264 16883807.837758932 1.0 0.6098323981659977 0.770644058261257 24.385000405394347 -10.141029783551799 5.236183197695887 1.0000098469652443 0.6902382282134046 0.8318535920242641 0.06565108532132373 7.547011287886111e-06 1.2381419206934365e-06 0.06356840956029505 0.021188796675715296 7.227202383540302e-11 10.141029783551799 -0.3097716187518397 IIWQFIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIWQFIK 7 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 38015600.0 8043600.0 17585000.0 12387000.0 False True 10412598.7630602 16606379.29154266 10132693.10135311 1.0 1.5948352250406073 0.9731185587693936 23.311826843768884 -6.65619811918358 1.9863046044036057 1.3840814116467526 0.9757213289405205 0.21957732743632896 0.25349953057579805 0.49353989813004245 3.7390775307637156 0.1032528266718626 0.28092680044296786 2.2069977012707834e-07 6.65619811918358 -0.40836008270623203 IIYEQEGVYIHSSCGK(ub)TNDQDGLISGILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIYEQEGVYIHSSCGKTNDQDGLISGILR 29 1 Q8TC07-2;Q8TC07;F8WCB5;F8WDJ1;F8WF35 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 132663000.0 84856000.0 17028000.0 30779000.0 True False 82162292.72782597 23827369.1998469 22717056.54979242 1.0 0.2900037037522599 0.2764900515257751 26.291973104642153 IIYEQEGVYIHSSCGK(ub)TNDQDGLISGILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIYEQEGVYIHSSCGKTNDQDGLISGILR 29 1 Q8TC07-2;Q8TC07;F8WCB5;F8WDJ1;F8WF35 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 1220994000.0 338678000.0 572114000.0 310202000.0 True False 513799286.67836124 470015786.75291544 248890438.7336332 1.0 0.9147848176113675 0.484411802793021 28.936629646405933 -6.9395815865394495 0.6634444231782323 1.004867274372766 0.3697685156638205 0.9981085844698221 0.00981417026425401 0.08795802970649137 0.05548276921982532 0.009523341624743501 0.037110153583216295 1.1492603231527856e-07 6.9395815865394495 -0.6350987587089455 down IIYEQEGVYIHSSCGK(ub)TNDQDGLISGILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIYEQEGVYIHSSCGKTNDQDGLISGILR 29 1 Q8TC07-2;Q8TC07;F8WCB5;F8WDJ1;F8WF35 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 179368000.0 84856000.0 36294000.0 58218000.0 True False 70561523.75818796 36098477.018205024 70391114.63038166 1.0 0.5115886831173505 0.997584956804642 26.07237838007643 -10.898982678050466 11.014896710574668 1.0189322624276969 0.7545868199622559 0.2537268553523587 0.19840714790464445 0.08076581946298281 0.0007406997232639112 0.16820085631520176 0.06403563163359997 1.2618778639171624e-11 10.898982678050466 -0.264345442465441 IIYEQEGVYIHSSCGK(ub)TNDQDGLISGILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIYEQEGVYIHSSCGKTNDQDGLISGILR 29 1 Q8TC07-2;Q8TC07;F8WCB5;F8WDJ1;F8WF35 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 973972000.0 338678000.0 480262000.0 155032000.0 True False 438425347.3414519 453534997.51577294 126817766.76265237 1.0 1.0344634503135912 0.2892573787798927 28.707755968498383 -6.896058674774896 0.9858620720454458 1.0344215827495096 0.21700929123698195 0.9845009096742008 0.04275900782757147 0.11436439551977728 0.19423839437878848 0.03275573045862385 0.0836573351814205 1.2704024575894432e-07 6.896058674774896 -0.8174122915125276 down IIYGGSVTGATCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIYGGSVTGATCK 13 0 P60174;P60174-3;P60174-4 P60174 TPI1 Triosephosphate isomerase 0 272181000.0 96540000.0 80644000.0 94997000.0 False True 126564874.89468995 68612229.54784986 85167621.71556939 1.0 0.5421111473853991 0.6729167297517126 26.915301833324925 -10.501055462527235 9.27772176386398 1.0000092205248732 0.6075139385685616 0.9231020004720716 0.053401155384177494 1.0184973431053064e-05 5.477509922170228e-07 0.051706659022538556 0.017235148789262838 3.1546017323312756e-11 10.501055462527235 -0.39249528195631156 IIYGGSVTGATCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIYGGSVTGATCK 13 0 P60174;P60174-3;P60174-4 P60174 TPI1 Triosephosphate isomerase 0 123768000.0 48906000.0 10978000.0 63884000.0 False True 47353505.79979092 15361572.649513716 47150863.92108055 1.0 0.32440201395989443 0.9957206573137979 25.496967903268278 -10.875338963222319 11.017219708299368 1.014387407102545 0.6600613356368461 0.2547807064557537 0.27406468850575083 0.08909114527633327 0.0010080742474996578 0.24409758873608053 0.08845399786385806 1.332481035866508e-11 10.875338963222319 -0.35432607146569883 IIYGGSVTGATCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIYGGSVTGATCK 13 0 P60174;P60174-3;P60174-4 P60174 TPI1 Triosephosphate isomerase 0 205887000.0 96540000.0 44265000.0 65082000.0 False True 132233446.89540352 42309225.935219735 49710972.00586404 1.0 0.319958580287832 0.37593342057539614 26.978511894847816 -10.63832904506527 10.186322853228308 1.0001349542135243 0.347946002880322 0.9945035003195327 0.022851632856385924 7.005011605373654e-05 2.4871636608702243e-06 0.022130355658098403 0.007375332790535789 2.2996987805993293e-11 10.63832904506527 -0.6521889513332022 IIYGGSVTGATCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIYGGSVTGATCK 13 0 P60174;P60174-3;P60174-4 P60174 TPI1 Triosephosphate isomerase 0 88221000.0 48906000.0 17408000.0 21907000.0 False True 40667505.9031529 17314219.64878256 26487652.41347643 1.0 0.4257507133586033 0.6513222737719668 25.277373178702554 -10.229982762695535 5.5154631675557 1.000026129773852 0.5385364935652631 0.8480274533134787 0.09208920391611619 2.9590475407627845e-05 4.131138450279143e-06 0.08917002602844305 0.029721662761037694 5.888670272362494e-11 10.229982762695535 -0.46148963620858885 IIYIVHDEVKDK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 IIYIVHDEVKDK 12 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 47267100.0 9457100.0 12340000.0 25470000.0 True False 12398349.682686673 10498920.100943252 22834608.725491848 1.0 0.846799805590592 1.8417458218151883 23.56364476360955 -6.867597551520825 1.1466479584230604 0.914485492866855 1.8974346668300033 0.9622303668737081 0.08500747275047361 0.13918357994920266 0.3435139427744662 0.057612377798674994 0.13586703132072958 1.3564458103008291e-07 6.867597551520825 0.9829491739631483 IIYIVHDEVKDK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 IIYIVHDEVKDK 12 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 78781000.0 20015000.0 17906000.0 40860000.0 True False 19379634.780657116 25055959.178556457 30157540.22627502 1.0 1.2929015155417118 1.5561459525736454 24.208038046878894 -6.972391752827281 0.1926800961981761 0.8277167417165148 2.0285423078271183 0.9999955229185098 0.0004806014254808331 0.07553403185316772 0.006166436137016128 0.009084601015785978 0.028486807510324712 1.0656344381693076e-07 6.972391752827281 1.2008255661106035 IIYIVHDEVKDK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIYIVHDEVKDK 12 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 306014000.0 48824000.0 156430000.0 100760000.0 True False 74069577.51251724 128513844.30683152 80844741.83532304 1.0 1.7350422214182817 1.0914702709308803 26.142377772409276 -10.26294993543864 5.3500399752120575 0.9999529143479303 1.4132562461745313 0.3547441935238762 0.26273714857710745 0.00014760500227651741 2.0335038446440765e-05 0.25442305444982444 0.08479805007241098 5.4582077854475095e-11 10.26294993543864 0.41330333182660095 IIYIVHDEVKDK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IIYIVHDEVKDK 12 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 40660800.0 9457100.0 9851700.0 21352000.0 True False 12953645.438517917 9416419.318784688 16309097.358243568 1.0 0.726931994817828 1.2590353376315326 23.62685482513244 -6.767232992043201 1.5852740344841825 0.8428213165871015 1.261704348434273 0.719784685255342 0.11500497568396806 0.27092574927009394 1.3433070131550637 0.05719979840896521 0.13649519639100133 1.7090981652647508e-07 6.767232992043201 0.41888303184717146 IIYIVHDEVKDK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IIYIVHDEVKDK 12 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 66058000.0 20015000.0 29743000.0 16300000.0 True False 16643359.314840851 29582768.55547671 19708254.637315243 1.0 1.7774517749609486 1.1841512440184736 23.98844332231317 -10.280983805569761 4.956972936945752 0.9998688337792738 1.480801509489991 0.46684596396803413 0.24221392748953646 0.00035120214273747554 5.0941966561045325e-05 0.23458606766884119 0.07817420894873371 5.23619961514556e-11 10.280983805569761 0.4809326757107171 IIYIVHDEVKDK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IIYIVHDEVKDK 12 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 292234000.0 48824000.0 170810000.0 72600000.0 True False 63203630.46492258 161304273.34594256 59387544.93890655 1.0 2.5521362010282767 0.9396223682414269 25.913504094501725 -6.6548381918629325 1.991114795566455 2.0032989303832816 0.9463753234289572 0.21394736553969484 0.6616864578314595 0.49679460133646147 3.7804801356349103 0.26899715857196416 0.7332080275417041 2.213919411425783e-07 6.6548381918629325 -1.0569236069543244 IIYTK(ub)SVDVTEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IIYTKSVDVTEK 12 1 Q7Z478;A0A087WYN9 Q7Z478 DHX29 ATP-dependent RNA helicase DHX29 1 8247200.0 2024200.0 4133000.0 2090000.0 True False 3070859.3888423163 3395433.8587236074 1676910.583920458 1.0 1.1056949956942355 0.5460720832784978 21.550211023785746 -6.857837384491402 1.196534419674454 1.0570533850445347 0.5200611852052565 0.9509590126886518 0.053760093704418824 0.14905493434387876 0.4067269898202536 0.035070899938005315 0.08168115490194644 1.3872751774665498e-07 6.857837384491402 -0.5369921998392783 IK(ub)AIPQLQGYLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKAIPQLQGYLR 12 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 33977200.0 8250400.0 17873000.0 7853800.0 True False 10816354.296987254 15206418.068408346 7041164.114969291 1.0 1.4058727784687937 0.6509738791498823 23.366710978168292 -6.7606866059721895 1.6101517750403218 1.2355510352246393 0.6481459057637775 0.6936947772355915 0.1707263026674963 0.28174877139800214 1.4398618891962052 0.08365815669520055 0.2008862795570667 1.7350555907129061e-07 6.7606866059721895 -0.5874051294608618 IK(ub)AIPQLQGYLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKAIPQLQGYLR 12 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 84214000.0 20679000.0 32868000.0 30667000.0 True False 20022556.464112297 45992363.804355666 22634392.709720414 1.0 2.2970275492438095 1.1304446937277703 24.25512285230322 -6.620851931686032 2.1141546631414148 1.8601418082988672 1.134974320289883 0.08541500204767771 0.5576561903541871 0.5831912632274555 4.954650912719664 0.2166767648228463 0.618087670091483 2.3941318723373966e-07 6.620851931686032 -0.7251674880089842 IK(ub)AIPQLQGYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKAIPQLQGYLR 12 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 37361500.0 9883100.0 8260400.0 19218000.0 True False 14993385.251391916 6786267.081200227 15419553.876451368 1.0 0.45261740210205176 1.028423776079514 23.837822820279474 -9.062991549517188 12.926727522572415 0.9999995627719854 0.7405205860349139 0.21307208601693384 0.23507196781463222 0.0 0.0 0.22760745412650707 0.07586915137550233 8.649847494469289e-10 9.062991549517188 -0.25947897673707154 IK(ub)AIPQLQGYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKAIPQLQGYLR 12 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 23981000.0 8250400.0 10265000.0 5465600.0 True False 11300795.838676576 9811458.358184364 4174737.8475653823 1.0 0.8682095047328431 0.3694198096453959 23.429921039691184 -6.94614677954861 0.5996571781146482 1.0056223928168477 0.2064887272361914 0.9988631537654773 0.00915683295157343 0.0850709064870366 0.04265736422298238 0.009401217678427115 0.04191233519988626 1.1320177078334942e-07 6.94614677954861 -0.7991336655806563 down IK(ub)AIPQLQGYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKAIPQLQGYLR 12 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 70033500.0 20679000.0 45765000.0 3589500.0 True False 17195504.73502839 45518454.86135877 4340047.854027184 1.0 2.6471136243319826 0.2523943275236473 24.035528127737496 -6.721623983741008 1.7534524554311672 2.000357298259499 0.2557903668387339 0.5201299843326755 0.6929796170387152 0.35219829379207346 2.1171325033567965 0.3136932949214743 0.7859930474133645 1.8983488182039752e-07 6.721623983741008 -1.7445669314207652 IK(ub)AIQLEYSEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKAIQLEYSEAR 12 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 18244900.0 6030900.0 5220400.0 6993600.0 True False 9149316.217848586 4288778.832828636 5611311.894596229 1.0 0.468754028247711 0.6133039629398338 23.125232495673746 -10.466447429822193 9.243010173772422 1.0000053722153752 0.5410289955938202 0.9307589286978942 0.05901226372472217 6.5330757259181084e-06 3.771313084148542e-07 0.05713904628329248 0.019046126218987436 3.4162730124838965e-11 10.466447429822193 -0.458976376621555 IK(ub)AIQLEYSEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKAIQLEYSEAR 12 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 17132500.0 6030900.0 4823100.0 6278500.0 True False 7807118.936811831 4554690.245154361 5135877.422850203 1.0 0.5834021848544229 0.6578454183186205 22.896358817766195 -10.765513939363831 7.022848915707351 1.008556770886927 0.6206238015865218 0.9719322519587055 0.03039132279836094 0.004085333735799612 0.0001364050885979204 0.02952487571149342 0.009808757255605465 1.715876635480263e-11 10.765513939363831 -0.3879329693004052 IK(ub)CSGCHSYQESTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKCSGCHSYQESTK 14 1 Q9UPT9;Q9UPT9-2 Q9UPT9 USP22 Ubiquitin carboxyl-terminal hydrolase 22 1 8714800.0 2558300.0 3740600.0 2415900.0 True False 3353956.0746124447 3182517.0607446 2165925.8429491874 1.0 0.94888453812334 0.6457824118043834 21.677432363964726 -6.9360846107867 0.6950335471406073 1.0037397071213543 0.5726734082917001 0.997604767454563 0.007650999754021224 0.08959916169459622 0.06308925723146667 0.0072428278363751665 0.026568370470689082 1.1585516210429471e-07 6.9360846107867 -0.4310662988296542 IK(ub)DAFDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKDAFDR 7 1 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 31772900.0 11205000.0 11082000.0 9485900.0 True False 14689863.509374369 9428608.79729767 8504390.063177992 1.0 0.6418445475195043 0.5789291410196491 23.808317655390717 -13.999999999999998 0.24464576029898702 3.425143884707756 0.5523113993511262 0.9995329188141143 0.004008010991629008 13.792013305718953 0.15652701335156077 16.385103990989133 0.029925514425265337 1.0000000000000041e-14 13.999999999999998 -2.8728324853566303 IK(ub)DAFDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKDAFDR 7 1 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 24317000.0 7432500.0 8051900.0 8832600.0 True False 7196559.355844803 11267065.6601038 6519077.087679795 1.0 1.565618388314003 0.9058602542317976 22.778875894398997 -6.679789773078164 1.9030879023598013 1.3579455860963359 0.9084001205937836 0.32302917608855264 0.23973393460010803 0.4389490516806855 3.073592045581899 0.10109819163229987 0.2666672320081856 2.090307731592655e-07 6.679789773078164 -0.44954546550255226 IK(ub)DAFDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKDAFDR 7 1 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 28380300.0 7432500.0 14348000.0 6599800.0 True False 6180453.065578535 14270704.476144968 7979787.6659725895 1.0 2.3090062046784796 1.2911331226533023 22.559281169833273 -10.194444804240586 4.9360876937899185 0.9999155040907545 1.80006966366728 0.45168588001442456 0.4155449456507719 0.00038644272650408446 6.306668052151289e-05 0.40239177719796376 0.13411655450815543 6.390799547328453e-11 10.194444804240586 0.8001541595765255 IK(ub)DAFDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKDAFDR 7 1 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 20820000.0 11166000.0 6216800.0 3437200.0 True False 14454607.114765782 5870829.614993592 2811664.868650266 1.0 0.4061562910967242 0.1945168655451086 23.78502606020864 -12.046060119138108 0.17434283305877601 2.521099761182069 1.581046388586223e-19 0.9994867730091914 0.0077241375451746605 5.456032349877285 0.11454380842500274 3.1580287415838666 0.1621909854652118 8.99373073209455e-13 12.046060119138108 -2.521099761182069 IK(ub)DAFDRNPELQNLLLDDFFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKDAFDRNPELQNLLLDDFFK 21 2 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 38997000.0 19639700.0 4638300.0 14719000.0 True False 19016248.47372825 6490397.378414966 10863652.33946505 1.0 0.34130798129724293 0.5712826246708779 24.180729323544444 -10.16230031762652 5.3075437717636245 1.0000194641459765 0.45629530298391585 0.8816925305542607 0.093886755008064 2.162467081035638e-05 3.4129324737961575e-06 0.09090870885027795 0.030301819881200346 6.881762531490909e-11 10.16230031762652 -0.5437241611620607 IK(ub)DAFDRNPELQNLLLDDFFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKDAFDRNPELQNLLLDDFFK 21 2 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 216065000.0 88420000.0 66513000.0 61132000.0 True False 134139604.36786768 54643235.48155909 49049233.40489256 1.0 0.407360941155784 0.36565810400319027 26.999160011177313 -13.999999999999996 0.37683542811283915 9.618454412321192 0.3617895195291598 0.9998023685102257 0.004072681489371128 23.640326697019965 0.1998897284381232 165.06783883188078 0.011411873013395602 1.0000000000000082e-14 13.999999999999996 -9.256664892792033 IK(ub)DAFDRNPELQNLLLDDFFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKDAFDRNPELQNLLLDDFFK 21 2 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 44735100.0 19639700.0 13800300.0 11295100.0 True False 16331280.736231793 13725955.044754907 13656853.187358266 1.0 0.8404702158051306 0.836238958103257 23.96113459897872 IK(ub)DAFDRNPELQNLLLDDFFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKDAFDRNPELQNLLLDDFFK 21 2 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 200070000.0 88420000.0 57741000.0 53909000.0 True False 114461433.01877053 54527662.591581665 44098115.15305117 1.0 0.47638458783439896 0.38526614589754016 26.770286333269762 -13.999999999999998 0.24598329383861386 4.569065218368923 0.3472030732192246 0.9995353032338178 0.005839264366599268 13.84233811808084 0.15695048980955756 24.35335673101535 0.043010908489170004 1.0000000000000041e-14 13.999999999999998 -4.221862145149698 IK(ub)DLSTVEALQNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKDLSTVEALQNLK 14 1 Q9BTT0;E9PPH5;Q9BTT0-3 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 40478630.0 12761630.0 17397000.0 10320000.0 True False 16730620.513800716 14801435.412974877 9252185.39643016 1.0 0.8846913598192908 0.5530091002182639 23.99598761799078 -6.952392024318209 0.5319361749531734 1.0051594855652632 0.4174339541351701 0.9993758727918431 0.0047335854986402925 0.08253922291282723 0.03209556418431933 0.005266066161310505 0.027435370633709908 1.1158555444371935e-07 6.952392024318209 -0.5877255314300931 IK(ub)DLSTVEALQNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKDLSTVEALQNLK 14 1 Q9BTT0;E9PPH5;Q9BTT0-3 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 74251900.0 24181900.0 30580000.0 19490000.0 True False 23414258.82100281 42790753.472593345 14384984.312533027 1.0 1.827551057657637 0.614368553047238 24.480884034420722 -6.7230319362283915 1.7481642520469844 1.5018227808069877 0.615896201310491 0.5269113242593091 0.3481126374579027 0.3494511474955017 2.0886515061653115 0.1580061326253259 0.3952831697540337 1.8922044686015664e-07 6.7230319362283915 -0.8859265794964967 IK(ub)DLSTVEALQNLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKDLSTVEALQNLK 14 1 Q9BTT0;E9PPH5;Q9BTT0-3 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 131189400.0 24159400.0 29696000.0 77334000.0 True False 36651576.088725 24396516.784092978 62048901.003303654 1.0 0.6656334975891527 1.6929395028769731 25.1273719025842 -6.8190553199790545 1.3759304725025474 0.8196033786595522 1.714920063114021 0.8822007615576002 0.1468383396433401 0.1947132406606766 0.7245850737505822 0.0838677051685112 0.19335442762830132 1.5168571394694553e-07 6.8190553199790545 0.8953166844544687 IK(ub)DLSTVEALQNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKDLSTVEALQNLK 14 1 Q9BTT0;E9PPH5;Q9BTT0-3 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 40839630.0 12761630.0 13250000.0 14828000.0 True False 17479949.48108336 12664571.188109381 11325931.79224596 1.0 0.7245198964570729 0.64793847399289 24.059197679513673 -13.999999999999998 0.1796039317512063 2.4276123282864606 0.586856483418095 0.99949861986694 0.003385167897476044 12.199589505252323 0.13434248723486353 6.077208766911426 0.05737125346317852 1.0000000000000041e-14 13.999999999999998 -1.8407558448683656 IK(ub)DLSTVEALQNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKDLSTVEALQNLK 14 1 Q9BTT0;E9PPH5;Q9BTT0-3 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 60498400.0 24181900.0 22558500.0 13758000.0 True False 20108321.289810095 22436972.882988326 16634734.190195296 1.0 1.1158053703049928 0.8272562363833403 24.261289309854998 -6.797768238039779 1.4648948313956922 1.0640769567315582 0.8234839490141395 0.8255901388313205 0.0495142198223518 0.22395801978034488 0.9490111557032789 0.02659308967354963 0.06193479544372424 1.593058638599364e-07 6.797768238039779 -0.24059300771741876 IK(ub)DLSTVEALQNLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKDLSTVEALQNLK 14 1 Q9BTT0;E9PPH5;Q9BTT0-3 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 144798300.0 24159400.0 25948900.0 94690000.0 True False 31274819.55297089 24504820.904083643 77457391.60144705 1.0 0.7835319677090146 2.4766694966938387 24.89849822467665 -6.874798039707675 1.1084575268578527 0.8732035133287215 2.5852809776438 0.9692389567809526 0.13195143331750045 0.1323348973556931 0.30101434447248787 0.09209219386931627 0.22003100237136197 1.3341417048581417e-07 6.874798039707675 1.7120774643150787 up IK(ub)DLSTVEALQNLK(ub)NLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKDLSTVEALQNLKNLK 17 2 Q9BTT0;E9PPH5;Q9BTT0-3 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 2 7014700.0 1961600.0 2176500.0 2876600.0 True False 1631157.3136143787 2164774.762498575 3478083.7601043642 1.0 1.3271403956138277 2.1322797814010332 20.637464495841687 -6.955796714674346 0.4911051224475322 0.9825553200977107 2.5110702762778594 0.9995811407377784 0.009737403873489474 0.08123827008570322 0.026950567690898063 0.011620002226470217 0.06640559088807853 1.1071418956365038e-07 6.955796714674346 1.5285149561801488 up IK(ub)DNDKEDGCFYFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKDNDKEDGCFYFR 14 2 A6NHR9-2;A6NHR9;J3KTL8;A6NHR9-3;A0A2R8YE92 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 1 16593400.0 3289200.0 4766900.0 8537300.0 True False 4257934.239825156 4501617.824558128 6983599.000095403 1.0 1.0572304716342869 1.6401378242943865 22.021722238087904 -6.925897429846804 0.7797262510481406 0.9896594747172103 1.748196280642139 0.9956687970917215 0.019034095332654506 0.09482455340298618 0.08852955130457704 0.01693506816849203 0.05398154369014218 1.1860488319600151e-07 6.925897429846804 0.7585368059249287 IK(ub)DTVLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKDTVLQR 8 1 P22102;P22102-2;F8WD69 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 10828600.0 3630500.0 3467600.0 3730500.0 True False 4759620.657812006 2950247.596598937 3344503.645482818 1.0 0.6198493133600197 0.702682815697393 22.182415164516684 -9.956665485911483 5.689180557617941 1.0000003927717778 0.6612660645284213 0.9570757967308652 0.0338166357233879 1.684725364213328e-07 3.087378984863994e-08 0.032742854800718264 0.010914272248305028 1.1049293609147825e-10 9.956665485911483 -0.3387343282433565 IK(ub)DTVLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKDTVLQR 8 1 P22102;P22102-2;F8WD69 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 20912900.0 3036600.0 6506300.0 11370000.0 True False 2940204.7951508057 9104299.519906264 8391855.907311477 1.0 3.0964848213708516 2.8541739409281695 21.487485216446508 -10.501810489905006 8.711516547925134 0.9999097073482648 2.97532938114951 0.988840257135535 0.09892300270151848 0.00017348620655349885 9.921306477105091e-06 0.09578584787820485 0.03192726183498437 3.1491221751050385e-11 10.501810489905006 1.9754196738012453 IK(ub)DTVLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKDTVLQR 8 1 P22102;P22102-2;F8WD69 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 20239700.0 4560700.0 3299000.0 12380000.0 True False 6918915.331831411 2710267.67479535 9933087.573653242 1.0 0.39171857795778986 1.4356423076829283 22.72211445573521 -6.748761453624741 1.6544931701266556 0.641788438796994 1.4375133546039418 0.643582310764996 0.2555897214966001 0.3022183526268325 1.6272925602452009 0.12205597010426976 0.2966977485403556 1.7833580494869646e-07 6.748761453624741 0.7957249158069478 IK(ub)DTVLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKDTVLQR 8 1 P22102;P22102-2;F8WD69 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 11117200.0 3630500.0 2689800.0 4796900.0 True False 4972793.960573458 2570955.7420208766 3663971.015256585 1.0 0.5170042761482916 0.7368033029934864 22.245625226039575 -10.33358258263935 5.82244744406155 1.000049163234689 0.6269037895708882 0.7934630243808243 0.08973257695517545 5.7273593539851076e-05 6.555467188723652e-06 0.08689460421280115 0.028961064679971938 4.63892570773644e-11 10.33358258263935 -0.37314537366380085 IK(ub)DTVLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKDTVLQR 8 1 P22102;P22102-2;F8WD69 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 15767300.0 3036600.0 9450400.0 3280300.0 True False 2525067.444189144 9399488.819442464 3966195.563606454 1.0 3.7224704001761237 1.5707285651849545 21.267890491880785 -6.587271638691542 2.239323455781788 2.8457708171243055 1.5767638210666282 0.0 1.1805613586352572 0.6776388779159331 6.402123997095865 0.4408094702545348 1.3167422360747238 2.5865945686777906e-07 6.587271638691542 -1.2690069960576773 IK(ub)DTVLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKDTVLQR 8 1 P22102;P22102-2;F8WD69 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 15437600.0 4560700.0 3007500.0 7869400.0 True False 5903916.05483721 2840129.981195027 6437249.946862684 1.0 0.4810586659456388 1.0903356157289028 22.49324077782766 -6.6811254532210995 1.8980522806858453 0.6719842855233312 1.088026434106543 0.32917052083396703 0.21988709675809673 0.43605099569783967 3.0382265457002036 0.09292860771208518 0.2447254771146607 2.083888830020482e-07 6.6811254532210995 0.41604214858321187 IK(ub)DYLLMEEEFIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKDYLLMEEEFIR 13 1 P62191 P62191 PSMC1 26S protease regulatory subunit 4 1 5893000.0 1847500.0 2510900.0 1534600.0 True False 2422090.3912154487 2136283.5074115423 1375814.3129226482 1.0 0.8819999101435337 0.5680276499640625 21.207821276026472 -6.954112762318231 0.5117073295745687 1.005698229099161 0.43051480011348503 0.9994857507330378 0.004134046320719285 0.08187514046898234 0.029444244570432845 0.004747698701972232 0.025915933062230934 1.1114431093536073e-07 6.954112762318231 -0.5751834289856759 IK(ub)DYLLMEEEFIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKDYLLMEEEFIR 13 1 P62191 P62191 PSMC1 26S protease regulatory subunit 4 1 28004900.0 10234000.0 7602900.0 10168000.0 True False 9909127.271808386 10638777.618599728 7504695.766538539 1.0 1.0736341684567123 0.7573518394389291 23.240326569614034 -6.845387180656369 1.257087293902333 1.0391905099313525 0.7457858810976858 0.93332622922224 0.03489159293935754 0.16260673753769286 0.4968005163163772 0.021741942381374734 0.05018749218220149 1.4276206437771228e-07 6.845387180656369 -0.2934046288336667 IK(ub)DYLLMEEEFIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKDYLLMEEEFIR 13 1 P62191 P62191 PSMC1 26S protease regulatory subunit 4 1 51559000.0 0.0 25140000.0 26419000.0 True False 0.0 20653570.58028349 21197273.07014094 0.0 IK(ub)DYLLMEEEFIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKDYLLMEEEFIR 13 1 P62191 P62191 PSMC1 26S protease regulatory subunit 4 1 8077100.0 1847500.0 2849800.0 3379800.0 True False 2530570.6768102106 2723886.4129716316 2581560.849165961 1.0 1.0763921505662493 1.0201496732824011 21.271031337549363 -10.376027760305988 5.576536929863201 0.9999840024987399 1.0482709119242886 0.4954990472313697 0.022960895202584746 4.568579925415654e-06 5.111704628368097e-07 0.022239158809901433 0.0074105970611352155 4.206997362014757e-11 10.376027760305988 0.048286909425548696 IK(ub)DYLLMEEEFIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKDYLLMEEEFIR 13 1 P62191 P62191 PSMC1 26S protease regulatory subunit 4 1 22797700.0 10234000.0 8473800.0 4089900.0 True False 8510024.443071755 8428149.957482396 4945079.180439002 1.0 0.9903790540042438 0.5810887164331152 23.02073184504831 -6.911961944843162 0.8822722444664376 1.0118996551772816 0.5259142866730334 0.9916410413599558 0.017851050628236748 0.10313476887460044 0.1318371927964774 0.014758174902970714 0.04131465529807184 1.2247235112511067e-07 6.911961944843162 -0.4859853685042482 IK(ub)DYLLMEEEFIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKDYLLMEEEFIR 13 1 P62191 P62191 PSMC1 26S protease regulatory subunit 4 1 54079000.0 0.0 29038000.0 25041000.0 True False 0.0 27422009.773546536 20483794.942357562 0.0 IK(ub)EENFVSPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKEENFVSPK 10 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 3428830.0 1039600.0 1498200.0 891030.0 True False 1362925.6675007227 1274674.3999378588 798834.7629632897 1.0 0.9352486568657149 0.5861176306321682 20.3782754505778 -6.93813749616118 0.6766733971467197 1.004073909711266 0.4969133678122361 0.9979095564658355 0.008311062213146328 0.08862687142690563 0.05855772363924846 0.007980250063460566 0.030303912514634126 1.1530881362298095e-07 6.93813749616118 -0.5071605418990299 IK(ub)EENFVSPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKEENFVSPK 10 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 14545400.0 4407300.0 4235500.0 5902600.0 True False 4267392.673934046 5926757.237840715 4356531.985795661 1.0 1.388847404187186 1.0208884718779438 22.024923438867706 -9.786632036979901 6.422759171483227 0.9999999967016164 1.2048679380326432 0.2924469212477616 0.15021860507643656 7.086735212533154e-09 1.349795079123577e-09 0.14544854110511493 0.04848284631258769 1.6344361638721082e-10 9.786632036979901 0.20486794133102681 IK(ub)EENFVSPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKEENFVSPK 10 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 20461300.0 4075800.0 8469700.0 7915800.0 True False 6183286.580892952 6958215.860931859 6351238.660381607 1.0 1.1253264376316514 1.0271622667478564 22.55994244201804 -10.250388137547727 4.1133562390121 0.9999370820671671 1.0762443521948042 0.4457855140667111 0.04007535496536396 2.314308438093797e-05 4.217528090727528e-06 0.03883480427532705 0.012934265195474281 5.618389741661777e-11 10.250388137547727 0.07630727012763705 IK(ub)EENFVSPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKEENFVSPK 10 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 4671920.0 1039600.0 2714900.0 917420.0 True False 1423968.2141336398 2594946.7410262744 700744.290857991 1.0 1.8223347370187422 0.4921066944491683 20.44148551210069 -6.739485611927875 1.6885604288086302 1.4895841836273613 0.49141641259250957 0.6026076067078687 0.3455154751546114 0.31876405885773346 1.7843752010685479 0.161887702211105 0.3974853622540357 1.821857429792181e-07 6.739485611927875 -0.9981677710348518 IK(ub)EENFVSPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKEENFVSPK 10 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 12658400.0 4407300.0 6806300.0 1444800.0 True False 3664865.226495025 6769633.110955228 1746900.9999995765 1.0 1.8471710943186623 0.47666173025147335 21.805328714301982 -6.739473423794633 1.6885169015756556 1.5043564382823316 0.47592915780433814 0.602667494231415 0.35594876463321584 0.3187469797842441 1.7841667310886873 0.16677893800881755 0.4095142953134613 1.821908559506264e-07 6.739473423794633 -1.0284272804779935 IK(ub)EENFVSPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKEENFVSPK 10 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 18670400.0 4075800.0 10287500.0 4307100.0 True False 5276203.446029233 9714991.581560714 3523251.9945780216 1.0 1.8412844919526419 0.667762725720812 22.33106876411049 -6.714306247626625 1.7798122513076333 1.5149357286550247 0.6701654436418064 0.48540784468298703 0.3542882298118588 0.36655968035044023 2.266026532660333 0.15825183304878787 0.3999550918128569 1.9306064481068257e-07 6.714306247626625 -0.8447702850132183 IK(ub)ELASCNPVVLEESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKELASCNPVVLEESK 16 1 Q9Y232-2;Q9Y232;Q9Y232-3;Q9Y232-4 Q9Y232-2 CDYL Chromodomain Y-like protein 1 78022600.0 26081600.0 30893000.0 21048000.0 True False 34193230.17457365 26283884.819970828 18870154.86667265 1.0 0.7686868039602683 0.5518681554895811 25.027207382294726 -6.971905952330644 0.20767678817607527 1.1169363871580782 0.19758152691384034 0.9999936786979404 0.0004600181440036562 0.07568895367808862 0.006770254949554582 0.006614104644692527 0.02259000997515498 1.0668271205765748e-07 6.971905952330644 -0.9193548602442378 IK(ub)ELASCNPVVLEESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKELASCNPVVLEESK 16 1 Q9Y232-2;Q9Y232;Q9Y232-3;Q9Y232-4 Q9Y232-2 CDYL Chromodomain Y-like protein 1 47283600.0 26081600.0 0.0 21202000.0 True False 35724672.34873784 0.0 16194524.268896626 1.0 0.0 0.4533148438929988 25.090417443817618 -9.821694008232217 20.61552385173028 0.9999999999999954 0.22665742194650265 0.7951010894197474 0.18506501006120968 0.0 0.0 0.1791884254831933 0.05972947516106442 1.5076689535098934e-10 9.821694008232217 -0.7733425780534928 IK(ub)ELHQQYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKELHQQYK 9 1 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 1 7011800.0 1994500.0 2628500.0 2388800.0 True False 1931185.6892341028 3678073.7574464185 1763101.6175361162 1.0 1.9045676332166284 0.912963278137874 20.881055459691154 -6.666680053401833 1.9493791224644295 1.579022735156044 0.9170423110462591 0.264374323815189 0.38453700072710995 0.46875360790396353 3.4309789045564383 0.15899764008572348 0.4266126064020278 2.1543682825518496e-07 6.666680053401833 -0.6619804241097849 IK(ub)ELHQQYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKELHQQYK 9 1 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 1 9396900.0 2198600.0 1459800.0 5738500.0 True False 3335436.939190158 1199287.2845305402 4604282.959726103 1.0 0.35955927406072513 1.38041373399313 21.669444334845597 -6.737121352085457 1.6974267376279115 0.6176724918473333 1.3806224001554819 0.5918781656521972 0.269109613863095 0.32304471605419927 1.826471341071128 0.12548428337488382 0.3088828188479233 1.8318025021813548e-07 6.737121352085457 0.7629499083081486 IK(ub)ELHQQYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKELHQQYK 9 1 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 1 9113100.0 2198600.0 1221000.0 5693500.0 True False 2846131.0408851933 1153050.2766547375 4657341.420243306 1.0 0.40512901904057097 1.636376313437345 21.440570656938046 -6.775307010150028 1.5539258639430047 0.6611187641675413 1.6447726488545655 0.7505184770893681 0.2511140972982741 0.25793150895226896 1.2297759902767997 0.12731892584703802 0.3016476232624782 1.677617662408036e-07 6.775307010150028 0.9836538846870242 IK(ub)ENSEK(ub)IK(ub)VNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKENSEKIKVNK 12 3 E9PMD8;E9PLG2;P17980;R4GNH3;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 3 2058540.0 513550.0 487590.0 1057400.0 True False 497247.6363530579 682287.2297482591 780435.2186799614 1.0 1.3721276480112186 1.5695101627910673 18.923604987718402 -11.034621524212737 0.11236071192683483 1.2322388651396898e-16 1.992071116483437 0.9998406726032304 0.0029804382191074455 3.389915288229527 0.06837548371761187 1.1537797634846114 0.28078137466247544 9.233757734046854e-12 11.034621524212737 1.9920711164834368 IK(ub)ENSEK(ub)IK(ub)VNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKENSEKIKVNK 12 3 E9PMD8;E9PLG2;P17980;R4GNH3;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 3 1697050.0 448100.0 640940.0 608010.0 True False 613774.679447175 612621.151494855 464410.56035901414 1.0 0.9981206002936468 0.7566466586358813 19.227349604780994 -6.90860581513681 0.9051773545468061 1.0078101514237094 0.7263532909415912 0.9903847110660617 0.011205769887490363 0.10534715546359004 0.1438218460457073 0.00911153839708456 0.024915496935635384 1.2342245617469543e-07 6.90860581513681 -0.28145686048211827 IK(ub)ENSEK(ub)IK(ub)VNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKENSEKIKVNK 12 3 E9PMD8;E9PLG2;P17980;R4GNH3;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 3 1962770.0 513550.0 1056900.0 392320.0 True False 427039.5791224838 1051206.2699217757 474352.29811727186 1.0 2.461613211782105 1.1107923511258844 18.70401026315268 -6.627535933197902 2.089951423457765 1.9646886943733055 1.1162301009799056 0.10851219801253231 0.6273536173792214 0.5654394575002141 4.703495407063799 0.2458207712204264 0.6948550870698798 2.3575671245654488e-07 6.627535933197902 -0.8484585933933999 IK(ub)EVTEEVANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKEVTEEVANK 11 1 Q8IWA4;Q8IWA4-3;H7C5H5 Q8IWA4 MFN1 Mitofusin-1 1 5015640.0 685540.0 1519600.0 2810500.0 True False 663777.907945624 2126384.2046093117 2074345.7368072928 1.0 3.203457329862661 3.1250599213633685 19.34034108844526 -10.26669050168195 4.255463694414996 0.9983608423175737 3.1642586256657683 0.9990168513287552 0.03200560819750641 2305687.981701258 2781990.0805936777 29340.661341589606 0.010956371263603982 5.4113982681385486e-11 10.26669050168195 2.1658977833481945 IK(ub)EVTEEVANK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKEVTEEVANK 11 1 Q8IWA4;Q8IWA4-3;H7C5H5 Q8IWA4 MFN1 Mitofusin-1 1 16828200.0 1868800.0 7005700.0 7953700.0 True False 2835106.2275805376 5755478.09921607 6381647.708769448 1.0 2.0300749380130845 2.250937776753257 21.43497136132854 -10.628643359118813 0.31362399651365785 5.9406886750564796e-12 2.3109638798510845 0.9991386609118196 0.015999327112715588 2.242825787032224 0.1535293106959376 1.8090964934223839 0.07494494446484275 2.3515631223366426e-11 10.628643359118813 2.310963879845144 IK(ub)EVTEEVANK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKEVTEEVANK 11 1 Q8IWA4;Q8IWA4-3;H7C5H5 Q8IWA4 MFN1 Mitofusin-1 1 11491900.0 1868800.0 5399400.0 4223700.0 True False 2419198.439555286 5098918.643545946 3455029.938821757 1.0 2.10768929087242 1.4281713654944672 21.20609768342099 -10.05558709404626 4.776795554309275 0.9999763405544663 1.7679303281972725 0.6300223893924521 0.277412031422649 6.99087828420807e-05 1.3821243381562595e-05 0.26861130294207264 0.08953434813803886 8.798586458626284e-11 10.05558709404626 0.7679539876428062 IK(ub)FESLEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKFESLEIK 9 1 O75665;O75665-3;A6NF31;O75665-2;A0A0A0MS89 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 6771070.0 947870.0 1326200.0 4497000.0 True False 1242666.7491861358 1128336.1294871103 4031693.5782700046 1.0 0.9079957520599111 3.2443883936787525 20.245008024397592 -6.8977300511101465 0.9754778986408132 0.8967192411198606 3.4786578462401767 0.9854036108557801 0.13052347553889623 0.11309652903465356 0.18698002271252698 0.10076444729330575 0.259317881987496 1.2655227270300377e-07 6.8977300511101465 2.581938605120316 up IK(ub)FESLEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKFESLEIK 9 1 O75665;O75665-3;A6NF31;O75665-2;A0A0A0MS89 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 53441400.0 5183900.0 9628500.0 38629000.0 True False 7864355.293854215 7910218.947186127 30993961.21830781 1.0 1.0058318389261678 3.9410682834394284 22.906897070186638 -6.907331373236498 0.9136960768223308 0.9012720973098265 4.29954244219779 0.989875423154206 0.13936609716895088 0.10620984282837484 0.14852761180166657 0.11261625804323662 0.30542106764658633 1.2378517265775463e-07 6.907331373236498 3.3982703448879636 up IK(ub)FESLEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKFESLEIK 9 1 O75665;O75665-3;A6NF31;O75665-2;A0A0A0MS89 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 6018650.0 947870.0 2268280.0 2802500.0 True False 1298323.1542235957 2168059.889401111 2140607.2192992503 1.0 1.6698923394750842 1.6487476267642664 20.308218085920483 -10.305544204415488 5.029775137651346 0.9997880957124957 1.6593199831198717 0.9992292071496853 0.008632292817222905 2.0518860435957638e-05 2.833000053330217e-06 0.008360816523645509 0.0027860605266265006 4.948297423946034e-11 10.305544204415488 0.659531887407376 IK(ub)FESLEIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKFESLEIK 9 1 O75665;O75665-3;A6NF31;O75665-2;A0A0A0MS89 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 34800300.0 5183900.0 8167800.0 21448600.0 True False 6710660.739945769 7713254.749926771 17545174.88122081 1.0 1.1494031733735215 2.614522706651178 22.678023392279087 -6.926515777391096 0.7748492276132795 0.9746082654831999 2.890257175097862 0.9958082434370412 0.047161741831713774 0.09448752361096466 0.08683945683117798 0.042107556916163545 0.1351963283465199 1.1843613398064887e-07 6.926515777391096 1.9156489096146623 up IK(ub)GEHPGLSIGDVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKGEHPGLSIGDVAK 15 1 Q5T7C4;P09429;B2RPK0 Q5T7C4 HMGB1;HMGB1P1 High mobility group protein B1;Putative high mobility group protein B1-like 1 1 30008700.0 9532800.0 12164000.0 8311900.0 True False 12497593.115766505 10349178.614900623 7451864.321374786 1.0 0.8280937392532389 0.596263956775308 23.575146940355125 -6.966965223901793 0.3225488391662268 1.0308142476492959 0.3860377520947971 0.9999481106758885 0.0011916384589077727 0.07730026130000048 0.012541313900405634 0.003478524581792615 0.020346875535700946 1.0790331222672316e-07 6.966965223901793 -0.6447764955544988 IK(ub)GEHPGLSIGDVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKGEHPGLSIGDVAK 15 1 Q5T7C4;P09429;B2RPK0 Q5T7C4 HMGB1;HMGB1P1 High mobility group protein B1;Putative high mobility group protein B1-like 1 1 36840500.0 17023000.0 8262500.0 11555000.0 True False 16482614.1829191 11561759.338368297 8528398.85743043 1.0 0.7014517970304568 0.5174178539147263 23.974441739841616 -9.3701274545282 0.10346741695365573 1.677940851915699 4.40036731848425e-12 0.9999470880005606 0.0014464627180383652 0.8227873029034225 0.038830948810331355 0.386121551876032 0.23062902083622255 4.264543467897117e-10 9.3701274545282 -1.6779408519112988 IK(ub)GEHPGLSIGDVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKGEHPGLSIGDVAK 15 1 Q5T7C4;P09429;B2RPK0 Q5T7C4 HMGB1;HMGB1P1 High mobility group protein B1;Putative high mobility group protein B1-like 1 1 24912300.0 9532800.0 7423100.0 7956400.0 True False 13057333.774233485 7095122.89709092 6077262.187201624 1.0 0.5433822110829384 0.46542902956146437 23.638357001878017 -13.999999999999998 0.24870193187814663 4.154907071360344 0.4336959756733265 0.9995402661518283 0.005055515591239344 13.946918303341539 0.15780841542548135 21.96509302396576 0.036236487423324935 1.0000000000000041e-14 13.999999999999998 -3.7212110956870177 IK(ub)GEHPGLSIGDVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKGEHPGLSIGDVAK 15 1 Q5T7C4;P09429;B2RPK0 Q5T7C4 HMGB1;HMGB1P1 High mobility group protein B1;Putative high mobility group protein B1-like 1 1 40997800.0 17023000.0 19144000.0 4830800.0 True False 14155378.746766703 19040867.47221353 5840897.944904459 1.0 1.3451330277236662 0.41262745768908554 23.754847015275892 -6.806486401508321 1.4291192932432637 1.1888918893096156 0.3975720335491905 0.8504882026298244 0.14884831244871038 0.21163070422139965 0.8524993265118278 0.0819099289265332 0.18980539168244864 1.5613979272030928e-07 6.806486401508321 -0.7913198557604251 down IK(ub)GEHPGLSIGDVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKGEHPGLSIGDVAK 15 1 Q5T7C4;P09429;B2RPK0 Q5T7C4 HMGB1;HMGB1P1 High mobility group protein B1;Putative high mobility group protein B1-like 1 1 34358300.0 9272300.0 15293000.0 9793000.0 True False 12003175.134358129 14441931.106372574 8010774.484665441 1.0 1.2031759051014512 0.6673879531870897 23.516912748768558 -6.803960946483963 1.4397851389537697 1.11154398692798 0.6592565814659581 0.8434648083220979 0.08737900243586891 0.21515300987091673 0.8800850099264634 0.04773587894892588 0.11075426226648995 1.5705040240566673e-07 6.803960946483963 -0.45228740546202184 IK(ub)GPNAVQLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKGPNAVQLVK 11 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 4464400.0 1752900.0 1235800.0 1475700.0 True False 1697255.1489889473 1729261.3846118636 1089169.899948949 1.0 1.0188576453233813 0.6417243162277434 20.694772031382822 -6.895130819856107 0.9915164503414857 1.0178424405059496 0.6058269472621113 0.9839848511134807 0.021957661869603858 0.11507951237731272 0.19831088133104938 0.016749240930899627 0.04260683008951248 1.2731195292852875e-07 6.895130819856107 -0.41201549324383835 IK(ub)GVEEEVLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKGVEEEVLTR 11 1 Q96M89-2;Q96M89;H7C005 Q96M89-2 CCDC138 Coiled-coil domain-containing protein 138 1 4723450.0 845950.0 2208500.0 1669000.0 True False 703444.9069392753 2196602.3721470754 2017980.1834159005 1.0 3.122635974016223 2.868711058263589 19.42407791197409 -10.160659179575667 5.604936977826216 0.9999605895638388 2.995673516140081 0.9880035863626325 0.10366441276282537 5.1056203037736364e-05 7.645508661092254e-06 0.10037459280171986 0.03345754535197432 6.907816945717138e-11 10.160659179575667 1.995712926576242 IK(ub)IIAPPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKIIAPPER 9 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 1 40961900.0 10302400.0 19254800.0 11404700.0 True False 13506546.168583516 16382058.894622535 10224651.045607261 1.0 1.2128977082777472 0.7570144815696846 23.68715546674376 -6.779700543643882 1.5368540437329359 1.1205950420038433 0.7534255418892527 0.7663815511838483 0.09002157658155172 0.25104451252344506 1.1711377353015573 0.04613426268470816 0.10889310037615271 1.6607316266216603e-07 6.779700543643882 -0.3671695001145906 IK(ub)IIAPPER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKIIAPPER 9 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 1 57702000.0 13318000.0 13227400.0 31156600.0 True False 12895227.379904635 18509169.79997975 22995751.782035258 1.0 1.4353504017171221 1.783276176880048 23.62033387642115 -6.97366093501283 0.14632481567713176 0.5741014370271902 2.6536475958850394 0.999998694862969 0.00036602704867119923 0.07513161511516545 0.0044570241015129556 0.01842565425248424 0.044071901825520586 1.0625247741619001e-07 6.97366093501283 2.079546158857849 IK(ub)IIAPPER ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKIIAPPER 9 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 1 131541700.0 18123600.0 20174100.0 93244000.0 True False 27494826.21263836 16573874.234037256 74814282.52970289 1.0 0.602799745154194 2.7210312933461465 24.712656831954074 -6.858229740313628 1.1947177310860375 0.7854386458068544 2.820154521717288 0.9514420208072476 0.20258391275688473 0.1486396511672475 0.4041682167770776 0.1323479452723939 0.3083358963165447 1.3860224337225623e-07 6.858229740313628 2.034715875910434 up IK(ub)IIAPPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKIIAPPER 9 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 1 35923800.0 10302400.0 9401500.0 16219900.0 True False 14111475.691891486 8986110.643396996 12389093.679326305 1.0 0.636794537977375 0.8779445856569863 23.750365528266652 -10.170945797401775 7.0556577767305635 1.0000003431014477 0.7573695618171806 0.5744235200684669 0.09844909471048043 5.313883515435732e-07 6.240837745908937e-08 0.09532306100299134 0.03177430868857395 6.746122181604403e-11 10.170945797401775 -0.24263078128426707 IK(ub)IIAPPER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKIIAPPER 9 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 1 29778600.0 13318000.0 5433500.0 11027100.0 True False 11074507.087436937 5404228.657034697 13332815.626450242 1.0 0.48798818894299356 1.2039195533655092 23.400739151855426 -6.714710304426611 1.7783679438712061 0.6867541881740689 1.2024860347801416 0.4874681471045693 0.21560720779549217 0.36568208882177555 2.2571691477291207 0.09637694987226238 0.2434587351277694 1.92881109512075e-07 6.714710304426611 0.5157318466060727 IK(ub)IIAPPER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKIIAPPER 9 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 1 101564200.0 18123600.0 16529600.0 66911000.0 True False 23461357.469565563 15609713.2293138 54733884.564837106 1.0 0.6653371719672642 2.3329376672189044 24.483783154046524 -6.854519858709428 1.213167741761495 0.820468567600409 2.4056096176518422 0.9466102338491033 0.16643636406728862 0.15256299405854648 0.42983573344819365 0.1072159616007599 0.24891689461594513 1.3979129923769757e-07 6.854519858709428 1.5851410500514334 up IK(ub)IIAPPERK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKIIAPPERK 10 2 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76;Q562R1 P60709;P63261;P68133;Q562R1 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2 1 20875700.0 2580200.0 2968500.0 15327000.0 True False 3914352.037887037 2438747.9820036376 12297611.731937256 1.0 0.623027249056544 3.141672392495258 21.900342080136838 -6.86879189491491 1.1403985025641628 0.7882574059287786 3.285872291341735 0.9634661099952432 0.21200613048634412 0.13802216988596336 0.3362256252929268 0.14437456604974624 0.3411313989295593 1.3527206041260878e-07 6.86879189491491 2.4976148854129567 up IK(ub)MAFRPGVVDLPEENR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKMAFRPGVVDLPEENR 17 2 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7 O60216 RAD21 Double-strand-break repair protein rad21 homolog 1 64056700.0 4809700.0 21093000.0 38154000.0 True False 7296666.536169797 17328789.34963879 30612845.176507708 1.0 2.3748912278969385 4.1954562435817655 22.798806092207432 -6.967246532254546 0.3171394477137732 0.742154952435688 5.886667605909194 0.9999522456261384 0.009044138199378372 0.07720669079946649 0.012213978809134897 0.027923321357122707 0.16055219674848653 1.0783344195280377e-07 6.967246532254546 5.144512653473506 IK(ub)MAFRPGVVDLPEENR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKMAFRPGVVDLPEENR 17 2 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7 O60216 RAD21 Double-strand-break repair protein rad21 homolog 1 83599700.0 4809700.0 20236000.0 58554000.0 True False 6226251.463361014 19109848.811126355 47897772.81477598 1.0 3.0692381963015998 7.692874773310252 22.56993241429988 -6.957820468015225 0.4651354848102812 0.8719230304475983 10.078190977531817 0.9996806211594204 0.050001803757895695 0.08048910437802605 0.024079258079312705 0.06336043241288168 0.38176368187628035 1.1019947664456964e-07 6.957820468015225 9.206267947084218 IK(ub)MATADEIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKMATADEIVK 11 1 Q3LXA3;H0YCY6;Q3LXA3-2 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 1 4598200.0 1272600.0 1532000.0 1793600.0 True False 1668390.9238759314 1303431.5716892295 1608015.4774260777 1.0 0.7812506967258941 0.9638121704057271 20.67002593835731 -10.066528854738127 5.99163303989236 1.0000003253767367 0.8725314336342616 0.39394671374757995 0.07453040953437697 3.2393848078275047e-07 5.043158102595163e-08 0.07216394260747055 0.024054586242718543 8.579681090074213e-11 10.066528854738127 -0.1274688917424751 IK(ub)MATADEIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKMATADEIVK 11 1 Q3LXA3;H0YCY6;Q3LXA3-2 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 1 3015000.0 1174400.0 1840600.0 0.0 True False 1137119.3148340583 2575561.178602198 0.0 1.0 2.264987627070651 0.0 20.11695220955984 -6.758093572306678 1.6389367546010143 1.739088516346729 4.758730857008777e-10 0.6706603786723363 0.5318640915400245 0.2889136192331646 1.5323214548091943 0.25695480220788186 0.6139760562114688 1.7454460417441525e-07 6.758093572306678 -1.7390885158708558 IK(ub)MATADEIVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKMATADEIVK 11 1 Q3LXA3;H0YCY6;Q3LXA3-2 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 1 5225000.0 1174400.0 2150200.0 1900400.0 True False 976565.6347413971 2138616.445818714 2297764.8535431847 1.0 2.189936210877457 2.3529036572658555 19.897357484994117 -10.653679380640963 0.39190608063590654 1.9457710794644484e-11 2.3690583862756966 0.9993461678111658 0.015419675635634745 2.2031956970029425 0.1881020250755625 2.169486145583341 0.04249500795709939 2.2198346153801226e-11 10.653679380640963 2.369058386256239 IK(ub)MATADEIVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKMATADEIVK 11 1 Q3LXA3;H0YCY6;Q3LXA3-2 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 1 12073800.0 2397600.0 2723800.0 6952400.0 True False 3103740.463761641 2572218.1355873663 5687134.537648123 1.0 0.8287478175510572 1.8323486142122478 21.565576493054547 -6.862964106583223 1.1707601123850409 0.9062590359129009 1.8837507673088225 0.9571373179849795 0.09075266205610572 0.143774271412486 0.37281241482771876 0.06038479235724146 0.14145144496861656 1.3709950709984543e-07 6.862964106583223 0.9774917313959216 IK(ub)NMQFSNTPDSGVSLLHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKNMQFSNTPDSGVSLLHK 19 1 E7EPJ2;A0A087WVF7;Q9NZM3-4;Q9NZM3-3;Q9NZM3-2;Q9NZM3 E7EPJ2 ITSN2 Intersectin-2 1 19015800.0 5217800.0 8881500.0 4916500.0 True False 5052163.795079326 12427929.26641063 3628721.1581615563 1.0 2.4599220790337606 0.7182508931511354 22.268469982503085 -6.684334786112711 1.8862783785534867 1.9200709985414257 0.7246008682312587 0.3441882948617552 0.6181684777148826 0.4289500950071867 2.9543474719636964 0.26259760884956157 0.6888137105996832 2.0685461465867504e-07 6.684334786112711 -1.195470130310167 IK(ub)NPEDGELIDQSEEGLIATGVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKNPEDGELIDQSEEGLIATGVR 23 1 Q9C0G0-3;Q9C0G0-2;Q9C0G0 Q9C0G0-3 ZNF407 Zinc finger protein 407 1 4484400.0 0.0 1906000.0 2578400.0 True False 0.0 1621632.2295298108 2311611.9017592524 0.0 IK(ub)NPEDGELIDQSEEGLIATGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKNPEDGELIDQSEEGLIATGVR 23 1 Q9C0G0-3;Q9C0G0-2;Q9C0G0 Q9C0G0-3 ZNF407 Zinc finger protein 407 1 11993500.0 3753300.0 3711900.0 4528300.0 True False 3634153.5459525525 5194081.027302779 3342202.3839119216 1.0 1.4292409392243641 0.9196646046048923 21.793187945226563 -6.683329737634267 1.8897739118560741 1.270761439014499 0.921536053958124 0.33958960719545317 0.18179010016059555 0.43114765512926645 2.9796392872511546 0.07710398973258514 0.2025142789912758 2.073338739422015e-07 6.683329737634267 -0.349225385056375 IK(ub)PKPQQGDDITVVDVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKPKPQQGDDITVVDVEK 18 2 F6R0L0;Q8NDZ2-3;Q8NDZ2;Q8NDZ2-4 F6R0L0 SIMC1 SUMO-interacting motif-containing protein 1 1 10948400.0 3305100.0 3104000.0 4539300.0 True False 5014078.335175741 2550066.9483373086 3642105.3653541324 1.0 0.508581393802243 0.7263758405614296 22.25755310496287 -10.309614869945051 5.751290181150152 1.000040930824909 0.6174786171818344 0.8044193286581849 0.08891421056196887 4.6669616695684384e-05 5.60232702669457e-06 0.08610000007409431 0.028696938062305895 4.9021334528025694e-11 10.309614869945051 -0.3825623136430746 IK(ub)QCLEDSDAGASNEYDSSPAAWNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKQCLEDSDAGASNEYDSSPAAWNK 25 1 P46063;F8WA66;F8WD97;F5H2L2;F5H4P4;F5H3W0;F5GYB7 P46063 RECQL ATP-dependent DNA helicase Q1 1 64074000.0 16333000.0 29135000.0 18606000.0 True False 21412721.16899701 24788171.5673405 16680829.601354608 1.0 1.1576376197916747 0.7790149355471178 24.351964811992723 -6.793602344973729 1.4817402513490192 1.087691052694062 0.7745684538800783 0.8128537878764504 0.06717973857903813 0.23001063843240874 0.9974962285305522 0.035678536872769916 0.0833245446909584 1.6084132977455436e-07 6.793602344973729 -0.31312259881398363 IK(ub)QCLEDSDAGASNEYDSSPAAWNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKQCLEDSDAGASNEYDSSPAAWNK 25 1 P46063;F8WA66;F8WD97;F5H2L2;F5H4P4;F5H3W0;F5GYB7 P46063 RECQL ATP-dependent DNA helicase Q1 1 37071900.0 16651000.0 13894000.0 6526900.0 True False 16122423.119296577 19441946.6562528 4817309.087197119 1.0 1.2058948281157043 0.2987955998643521 23.942565254198833 -6.847040901592217 1.2491749396889285 1.1096625028186955 0.2645308132994741 0.9358975459439078 0.09830859340702373 0.16074787775713603 0.48417005357391835 0.061623265582254 0.14236560475667273 1.4221948393636572e-07 6.847040901592217 -0.8451316895192214 down IK(ub)QCLEDSDAGASNEYDSSPAAWNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKQCLEDSDAGASNEYDSSPAAWNK 25 1 P46063;F8WA66;F8WD97;F5H2L2;F5H4P4;F5H3W0;F5GYB7 P46063 RECQL ATP-dependent DNA helicase Q1 1 95932000.0 41198000.0 33271000.0 21463000.0 True False 62500377.97723826 27333530.102490537 17220828.64243292 1.0 0.4373338368040753 0.2755315919642038 25.897361578854074 -13.999999999999927 0.17477443621394492 3.874747281095149 0.13982355362337104 0.9995053815103591 0.006905266741113266 12.14157923905003 0.13246807051196582 11.8407388205384 0.12639434901906144 1.0000000000001677e-14 13.999999999999927 -3.734923727471778 IK(ub)QCLEDSDAGASNEYDSSPAAWNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKQCLEDSDAGASNEYDSSPAAWNK 25 1 P46063;F8WA66;F8WD97;F5H2L2;F5H4P4;F5H3W0;F5GYB7 P46063 RECQL ATP-dependent DNA helicase Q1 1 60112000.0 16333000.0 28511000.0 15268000.0 True False 22371751.48272867 27251289.74673106 11662012.854330404 1.0 1.2181115889727931 0.5212829609399896 24.415174873515614 -6.822595822357844 1.3607076091186208 1.1172588595530837 0.505218705505083 0.8902361346832488 0.09642175864023682 0.19012421957689934 0.6909960165866732 0.055676132116274 0.1282378158083291 1.5045415214415834e-07 6.822595822357844 -0.6120401540480007 IK(ub)QCLEDSDAGASNEYDSSPAAWNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKQCLEDSDAGASNEYDSSPAAWNK 25 1 P46063;F8WA66;F8WD97;F5H2L2;F5H4P4;F5H3W0;F5GYB7 P46063 RECQL ATP-dependent DNA helicase Q1 1 40670200.0 16651000.0 15122000.0 8897200.0 True False 13846044.264372444 15040534.784518015 10757563.383995172 1.0 1.086269442545344 0.7769412821881331 23.72297052963311 -6.832270369835654 1.3176271119858929 1.0460306726751039 0.7682186085152556 0.9103535183235506 0.03902319826784571 0.17803040658825803 0.6036678297359234 0.02324707065103371 0.05350046267917072 1.4713962001935688e-07 6.832270369835654 -0.27781206415984827 IK(ub)QCLEDSDAGASNEYDSSPAAWNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKQCLEDSDAGASNEYDSSPAAWNK 25 1 P46063;F8WA66;F8WD97;F5H2L2;F5H4P4;F5H3W0;F5GYB7 P46063 RECQL ATP-dependent DNA helicase Q1 1 89407000.0 41198000.0 34657000.0 13552000.0 True False 53331623.133988954 32728307.484048545 11085675.055262564 1.0 0.6136754435885593 0.20786307267287193 25.668487900946523 -7.570821837868932 0.36485665536314815 1.0546021686156382 2.1795590398424433e-13 0.9991339611175313 0.009517810505722013 0.12255391492284995 0.04653696449176073 0.02314855159101951 0.06998510263585517 2.6864462898121177e-08 7.570821837868932 -1.05460216861542 down IK(ub)QEILPEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKQEILPEER 10 1 O75534-2;O75534;O75534-3;O75534-4 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 27030200.0 9296200.0 11620000.0 6114000.0 True False 12034114.155497551 10973336.785199082 5001314.734937666 1.0 0.911852475671101 0.415594755900908 23.520626611548902 -6.937197287618345 0.6851414912795726 1.005931947080907 0.2921274504463293 0.9977732713007431 0.012138896086226801 0.08906885766812758 0.06060870512917504 0.011578987178912084 0.04326565836808075 1.1555871725872185e-07 6.937197287618345 -0.7138044966345776 down IK(ub)QHLENDPGSNEDTDIPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKQHLENDPGSNEDTDIPK 19 1 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 1 56570600.0 14532000.0 22061600.0 19977000.0 True False 19051592.728088167 18770095.275443252 17909971.672915217 1.0 0.9852244661817751 0.9400773955507754 24.183408277408443 -6.951037638561143 0.5473340435611618 1.0006344657874837 0.922556129606431 0.9992801629657591 0.0006838451906302358 0.08307173588578899 0.034258615183127186 0.0007447980844844963 0.003743485589805622 1.1193408704788746e-07 6.951037638561143 -0.07807833618105275 IK(ub)QHLENDPGSNEDTDIPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKQHLENDPGSNEDTDIPK 19 1 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 1 101739800.0 20362000.0 26045800.0 55332000.0 True False 19715619.455595303 36446023.767052636 40838889.27558123 1.0 1.8485862870876844 2.0713977244063275 24.2328357041767 -10.757454108397319 0.26837823684654233 1.487024248904284e-10 2.1647216927148003 0.9991692008949504 0.01330484690427245 2.5150499948994804 0.13657329270558638 1.7107938089338899 0.09245412898620203 1.7480179645294305e-11 10.757454108397319 2.164721692566098 IK(ub)QHLENDPGSNEDTDIPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKQHLENDPGSNEDTDIPK 19 1 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 1 244153000.0 52514000.0 143431000.0 48208000.0 True False 79667577.28765208 117834617.41848212 38679667.66968302 1.0 1.479078709686653 0.48551329143629046 26.247489367054957 -6.775579782763315 1.5529364887985386 1.2728261042839153 0.4786869650321016 0.7514780313407065 0.20225307906266288 0.25751119323546745 1.2262467695353374 0.10260975378083724 0.2430414589733943 1.6765643115245723e-07 6.775579782763315 -0.7941391392518137 down IK(ub)QHLENDPGSNEDTDIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKQHLENDPGSNEDTDIPK 19 1 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 1 63500400.0 14532000.0 23282800.0 25685600.0 True False 19904873.112533674 22254088.910076436 19619190.291537173 1.0 1.1180221438369036 0.9856475939644844 24.246618338931334 -6.671578339742899 1.9318556744437307 1.0752314845183923 0.9861799335658051 0.28600465933222985 0.05011523983600325 0.4575153835193384 3.293372838923476 0.020873548569054122 0.05565277040844089 2.130206277916191e-07 6.671578339742899 -0.08905155095258721 IK(ub)QHLENDPGSNEDTDIPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKQHLENDPGSNEDTDIPK 19 1 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 1 94447800.0 20362000.0 48292000.0 25793800.0 True False 16931905.1895473 48031841.41078846 31187164.322943725 1.0 2.8367653180836565 1.8419170184225182 24.013240979610977 -10.594273583985162 6.104736620519944 0.9955327700484723 2.339341168253087 0.7073126386654318 0.40614511760754063 0.024678458993047114 0.0016401511386044169 0.3930036812893358 0.1310827730531215 2.545226381066424e-11 10.594273583985162 1.3438083982046147 IK(ub)QHLENDPGSNEDTDIPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKQHLENDPGSNEDTDIPK 19 1 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 1 302653000.0 52514000.0 35089000.0 215050000.0 True False 67980408.20569679 33136266.30429007 175913106.59933662 1.0 0.4874384720377898 2.587703005063671 26.018615689147406 -6.842185431182781 1.2720748454750104 0.7273408464516999 2.6598796010043673 0.928159403681693 0.23964478337658482 0.1662685605042063 0.5216670969165543 0.1476581476521459 0.34042688528575704 1.4381843840078663e-07 6.842185431182781 1.9325387545526673 up IK(ub)QIESDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKQIESDR 8 1 Q53HL2 Q53HL2 CDCA8 Borealin 1 5697000.0 1986500.0 2707800.0 1002700.0 True False 2604320.737293367 2303806.7949217283 898950.2225775688 1.0 0.8846094729929623 0.3451764637530149 21.31247570508106 -6.941315645383378 0.6472074175004228 1.0059442357629975 0.1938996039397759 0.9983312056806757 0.011658985521652438 0.08717150902425157 0.05191447596831733 0.011465655379295336 0.046165438363148875 1.1446806847125587e-07 6.941315645383378 -0.8120446318232216 down IK(ub)QIESDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKQIESDR 8 1 Q53HL2 Q53HL2 CDCA8 Borealin 1 5282100.0 2144400.0 2755400.0 382300.0 True False 2076327.1957852128 3855645.589221181 282164.16124583816 1.0 1.8569547213213071 0.13589580766394144 20.985602376479275 -6.771329856689042 1.5694554410943342 1.4906923535093113 0.12574653687054038 0.7355898913265605 0.3612936995141239 0.2642840205976577 1.2849329843430715 0.18143522852575097 0.4313501174078184 1.6930514003442707e-07 6.771329856689042 -1.364945816638771 IK(ub)QIESDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKQIESDR 8 1 Q53HL2 Q53HL2 CDCA8 Borealin 1 5219200.0 1986500.0 1629100.0 1603600.0 True False 2720962.733143973 1557120.9752867161 1224862.70717869 1.0 0.5722683946823188 0.4501578401860013 21.37568576660395 -13.999999999999998 0.17581100857748186 3.1918340281960385 0.348845587690622 0.99950379325035 0.00525143583498914 12.153381979473261 0.132874300614048 9.091867970595418 0.09452460869111436 1.0000000000000041e-14 13.999999999999998 -2.842988440505416 IK(ub)QIESDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKQIESDR 8 1 Q53HL2 Q53HL2 CDCA8 Borealin 1 5499010.0 2144400.0 2780200.0 574410.0 True False 1783163.6130274618 2765222.5107735097 694516.4752282363 1.0 1.5507396464190433 0.38948555822596875 20.76600765191355 -6.777735833560694 1.5446656358969437 1.3127588685377278 0.3809269106940394 0.7593075427029923 0.23268831325336653 0.25410723021900944 1.197388176893215 0.1186660100309945 0.28053967269763763 1.6682616503451556e-07 6.777735833560694 -0.9318319578436884 down IK(ub)QIESDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKQIESDR 8 1 Q53HL2 Q53HL2 CDCA8 Borealin 1 1825580.0 1251800.0 289850.0 283930.0 True False 1620479.7766670096 273719.5927013725 232257.65336781993 1.0 0.16891268662689324 0.14332647448740501 20.62798958548485 -13.009552670659515 0.5086653218552856 9.999999999959789 0.1448077194199877 0.9999346165754739 0.0032177881608642044 17.696596584300377 0.2536737611703152 176.05886205581743 0.0051292001149380075 9.782443074161859e-14 13.009552670659515 -9.8551922805398 IK(ub)QITEEVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKQITEEVER 10 1 O95140;O95140-2 O95140 MFN2 Mitofusin-2 1 2678600.0 0.0 1022000.0 1656600.0 True False 0.0 869521.5837247993 1485190.9232292837 0.0 IK(ub)QITEEVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKQITEEVER 10 1 O95140;O95140-2 O95140 MFN2 Mitofusin-2 1 19184900.0 1419200.0 9814600.0 7951100.0 True False 2153030.1574177505 8063107.948180204 6379561.599909072 1.0 3.7450046486347133 2.9630618864904505 21.037937096749584 -10.152025272135818 5.725859411472895 0.9999671581708972 3.354033267562711 0.9235713072040758 0.3192267958864439 0.00013383743846479717 1.9819007058232645e-05 0.3090942679028174 0.10303000534421265 7.046520631944875e-11 10.152025272135818 2.354066109391814 IK(ub)QITEEVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKQITEEVER 10 1 O95140;O95140-2 O95140 MFN2 Mitofusin-2 1 12152300.0 1419200.0 6255200.0 4477900.0 True False 1837182.376614328 5907092.621237289 3662968.147134017 1.0 3.21530006842502 1.9937966931102173 20.809063418842033 -10.27806173767918 5.88499894099399 0.9999094795109387 2.6045483807676257 0.6970315479887772 0.4986766647681323 0.0005922941067544136 7.265886880068159e-05 0.4828681085119981 0.16094720148243252 5.271549177246764e-11 10.27806173767918 1.604638901256687 IK(ub)QSSPNYHEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKQSSPNYHEEK 12 1 O00472-2;O00472 O00472-2 ELL2 RNA polymerase II elongation factor ELL2 1 2723590.0 520300.0 874490.0 1328800.0 True False 682118.3385923668 744019.5007353208 1191308.5227496496 1.0 1.0907484209714908 1.746483645650193 19.37966252408229 -6.932040332917048 0.7298478326399722 0.9907446840056578 1.8883761713206881 0.9969243437519489 0.018444204110371683 0.09159194251540144 0.0725902776522351 0.01701236914314882 0.058681104078653776 1.169390784685569e-07 6.932040332917048 0.8976314873150303 IK(ub)QSSPNYHEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKQSSPNYHEEK 12 1 O00472-2;O00472 O00472-2 ELL2 RNA polymerase II elongation factor ELL2 1 3517070.0 520300.0 546270.0 2450500.0 True False 712668.9705788104 522133.98512667906 1871742.369631692 1.0 0.7326458800396711 2.6263839831717575 19.44287258560518 -6.871146821507372 1.1280776330407771 0.8477084389027351 2.7397028356708635 0.9658110822482373 0.1547354446404766 0.13575656504992614 0.32219382007858943 0.1063811406810764 0.2523629539391552 1.3454054372737612e-07 6.871146821507372 1.8919943967681285 up IK(ub)SDYAQLLEDMQNAFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKSDYAQLLEDMQNAFR 17 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 10450700.0 1526000.0 2227200.0 6697500.0 True False 1477557.965290167 3116532.5746945674 4943223.82930683 1.0 2.109245557809662 3.3455363142630183 20.49478329843852 -6.969723780810341 0.2646992603215421 0.6722314833206159 4.819456262586654 0.9999801478881525 0.004268563515470908 0.07639242560423794 0.00935031625219976 0.025045461508721494 0.11584315397291396 1.0722010277760609e-07 6.969723780810341 4.147224779266039 IK(ub)SDYAQLLEDMQNAFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKSDYAQLLEDMQNAFR 17 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 91642000.0 4918000.0 14438000.0 72286000.0 True False 7460965.553960333 11861426.09539112 57998640.41592064 1.0 1.5897977292087875 7.77361053290677 22.830930916931965 -6.925435374892242 0.7833553387779293 0.8883771187856558 8.907146023293846 0.9955625306921344 0.20407773305689397 0.09507806155820027 0.08980643974630022 0.18110290844372312 0.5742095599760149 1.1873113655408808e-07 6.925435374892242 8.01876890450819 up IK(ub)SDYAQLLEDMQNAFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKSDYAQLLEDMQNAFR 17 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 8889800.0 1526000.0 2189800.0 5174000.0 True False 1268936.6132624072 2178003.1127587305 6255859.47812695 1.0 1.716400244106074 4.930001556219011 20.275188573872796 -6.9422519483128085 0.6382686670434741 0.9648581904260607 5.857210861371171 0.9984442460644395 0.06740719974985154 0.08675411910009213 0.050042632405211424 0.06679493534536528 0.27396163219846226 1.1422155062877855e-07 6.9422519483128085 4.89235267094511 IK(ub)SDYAQLLEDMQNAFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKSDYAQLLEDMQNAFR 17 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 69353200.0 4918000.0 5857200.0 58578000.0 True False 6366447.9482731605 5531241.671107395 47917405.0610367 1.0 0.8688112611692195 7.526552553380076 22.602057239024415 -6.902408447789991 0.9459412997795306 0.7411894459162018 8.260543374382825 0.9877262326200642 0.34432935965719874 0.1096533195512203 0.16760054893409967 0.2717275772430174 0.7159062521973744 1.2519631675068447e-07 6.902408447789991 7.519353928466623 up IK(ub)SEHPGLSIGDTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKSEHPGLSIGDTAK 15 1 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 1 11885400.0 3758600.0 5183900.0 2942900.0 True False 4927560.9983341815 4410482.32668394 2638396.9382901443 1.0 0.895063973469827 0.5354366874772498 22.232442299841953 -6.948426523027664 0.5758588106720279 1.0043688276673408 0.40847017452731027 0.999071950076073 0.0060602182989795235 0.08412378800467576 0.0386251385815637 0.006378340474433433 0.030008528346296647 1.1260909727113082e-07 6.948426523027664 -0.5958986531400305 IK(ub)SEHPGLSIGDTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKSEHPGLSIGDTAK 15 1 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 1 15544900.0 5598700.0 6071400.0 3874800.0 True False 5420972.33307344 8495741.68193273 2859873.638491693 1.0 1.567198863956577 0.5275573204909306 22.370120213207887 -6.758603477996526 1.6181756786905672 1.3300405216342068 0.5240770992143474 0.6850654898248176 0.2385165842446026 0.2852701825662628 1.4719745498319219 0.11632728321958548 0.2798896584255927 1.7433979139716657e-07 6.758603477996526 -0.8059634224198594 IK(ub)SEHPGLSIGDTAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKSEHPGLSIGDTAK 15 1 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 1 14574700.0 6303400.0 4055700.0 4215600.0 True False 9562718.6402671 3331928.647671267 3382384.81223688 1.0 0.34842901616293936 0.353705357176796 23.18898939791205 -9.92561341416189 6.153280546072517 1.0000001589269891 0.35106718666976255 0.9999504197064305 0.0021540571991865657 4.695180689355429e-09 8.2074802066457e-10 0.0020856574274295517 0.0006952189715472273 1.186824726327701e-10 9.92561341416189 -0.6489329722572266 IK(ub)SEHPGLSIGDTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKSEHPGLSIGDTAK 15 1 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 1 10194000.0 3758600.0 3745200.0 2690200.0 True False 5148255.992345803 3579724.6802797923 2054830.166408153 1.0 0.6953276382530252 0.3991313115476741 22.295652361364844 -7.0963817001474405 0.23334262497683717 1.1227030351876415 1.3177728140817037e-11 0.999986911365567 0.0008874754130971546 0.07609000129195471 0.008771792541235819 0.008815481169061456 0.030570090066911176 8.009737804285435e-08 7.0963817001474405 -1.1227030351744638 down IK(ub)SEHPGLSIGDTAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKSEHPGLSIGDTAK 15 1 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 1 18998200.0 5598700.0 11372000.0 2027500.0 True False 4655567.114464122 11310736.778834745 2451440.8758991864 1.0 2.4295078345437333 0.5265611719532388 22.150525488642163 -6.705633807399436 1.8103925283241478 1.8826639372051868 0.5314781133429864 0.444649219780332 0.6028058043516255 0.3838451879949603 2.4494607168891105 0.26523294933531216 0.6775031307212374 1.969546290755488e-07 6.705633807399436 -1.3511858238622003 IK(ub)SEHPGLSIGDTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKSEHPGLSIGDTAK 15 1 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 1 14632600.0 6303400.0 6039400.0 2289800.0 True False 8159875.55858989 5703302.080940725 1873079.8953320705 1.0 0.6989447375746886 0.22954760546075753 22.9601157200045 -7.208093304524671 0.4238117095028198 1.0235900309134036 7.747402622623796e-12 0.9995708031922923 0.006567902065899013 0.08937788076178588 0.028519553740523798 0.00945376590701001 0.04568643346002839 6.193080076551094e-08 7.208093304524671 -1.0235900309056563 down IK(ub)SGEEDFESLASQFSDCSSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKSGEEDFESLASQFSDCSSAK 22 1 Q13526;K7EMU7;K7EN45 Q13526 PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 1 8268200.0 2265000.0 1799800.0 4203400.0 True False 3102431.709323482 1720278.8848573002 3210643.4917404014 1.0 0.5544937152645417 1.0348796661959454 21.56496802344945 -11.92413435038792 17.92363141062824 0.8997923814481252 0.8152180228125433 0.0 0.22388448004390388 0.0 0.0 0.0 0.06510065219251786 1.190873550494363e-12 11.92413435038792 -0.08457435863558194 IK(ub)SGEEDFESLASQFSDCSSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKSGEEDFESLASQFSDCSSAK 22 1 Q13526;K7EMU7;K7EN45 Q13526 PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 1 21074300.0 4389800.0 4720500.0 11964000.0 True False 5682682.635894579 4457800.0253470065 9786674.761006592 1.0 0.7844534546394304 1.7221927367875884 22.43814071592827 -6.846226117773959 1.2531044331043555 0.8852438564235098 1.7570495368705086 0.9346388734404898 0.10252491933028275 0.1616586794727413 0.4903833308113213 0.06407777106705323 0.1479710583546482 1.42486553648288e-07 6.846226117773959 0.8718056804469988 IK(ub)SLEEIYLFSLPIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKSLEEIYLFSLPIK 15 1 P15880;H0YEN5;E9PQD7;E9PMM9;E9PPT0;H3BNG3;H0YE27 P15880 RPS2 40S ribosomal protein S2 1 7602500.0 2809400.0 2996600.0 1796500.0 True False 2720217.1347878133 4193158.0070625646 1325942.7561552378 1.0 1.54147915379176 0.4874400426341944 21.37529038505665 -6.7670500561418425 1.5856172740922003 1.3117395056463892 0.48214131996423965 0.7192239397183787 0.22804240829772743 0.2712123017216541 1.345221662509913 0.11339052888998155 0.27066767485057847 1.7098182326035364e-07 6.7670500561418425 -0.8295981856821495 down IK(ub)SLEEIYLFSLPIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKSLEEIYLFSLPIK 15 1 P15880;H0YEN5;E9PQD7;E9PMM9;E9PPT0;H3BNG3;H0YE27 P15880 RPS2 40S ribosomal protein S2 1 6247380.0 2809400.0 2602200.0 835780.0 True False 2336140.5775225516 2588181.432103738 1010537.7337898983 1.0 1.1078877089016932 0.4325671766129593 21.155695660490927 -6.865990613303972 1.1550107887408467 1.0597687371632982 0.3959038461676034 0.9605197619527222 0.05885637780168619 0.14076174683295956 0.35347538072229523 0.039633964228188844 0.09324073821722415 1.361474108595068e-07 6.865990613303972 -0.6638648909956948 down IK(ub)SLNWEEMEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKSLNWEEMEK 11 1 K7ENR6;Q969U7-2;Q969U7;V9GZ55 K7ENR6 PSMG2 Proteasome assembly chaperone 2 1 3343100.0 871300.0 1343000.0 1128800.0 True False 1142282.7376812033 1142629.6349729972 1012002.6042141826 1.0 1.0003036877651659 0.885947559943447 20.123488359923506 -6.906300647835535 0.9205647928637225 1.0039681105903833 0.8722814766529952 0.98944889822541 0.005530010574307735 0.10691525009678303 0.1524153339399759 0.004446260758895245 0.011980696244354654 1.2407930498481352e-07 6.906300647835535 -0.1316866339373881 IK(ub)SLNWEEMEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKSLNWEEMEK 11 1 K7ENR6;Q969U7-2;Q969U7;V9GZ55 K7ENR6 PSMG2 Proteasome assembly chaperone 2 1 6031900.0 1913900.0 1974700.0 2143300.0 True False 1853144.2921158953 2763208.0079244636 1581905.4323782471 1.0 1.4910916649504231 0.8536331677508224 20.82154378820443 -6.700955788028038 1.8276115493408427 1.3046638304144391 0.855504045330097 0.4220625520595729 0.2072598673710956 0.3935289629593753 2.556178185404395 0.09045247261444522 0.23233283182492534 1.990876003486827e-07 6.700955788028038 -0.44915978508434207 IK(ub)SLNWEEMEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKSLNWEEMEK 11 1 K7ENR6;Q969U7-2;Q969U7;V9GZ55 K7ENR6 PSMG2 Proteasome assembly chaperone 2 1 6147900.0 1913900.0 2832900.0 1401100.0 True False 1591492.6501460853 2817638.605413378 1694063.5320455474 1.0 1.7704377115123613 1.064449485135886 20.601949063638706 -10.233581498067881 4.487340601646468 0.9998481492491207 1.4174435983288856 0.31794840911531164 0.28821848652198556 203278419.04783267 85.39767156254418 318943.2374869667 0.09866485409638723 5.840076041404016e-11 10.233581498067881 0.41759544907976487 IK(ub)VAEDEAEAAAAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKVAEDEAEAAAAAK 15 1 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5H0E2;H0YFS2;F5H867 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 1 63459500.0 17363900.0 17705600.0 28390000.0 True False 26342305.77112892 14545897.3455158 22778704.05622094 1.0 0.5521877041400854 0.8647194461308823 24.650878296023947 -10.077772627451727 5.817681166466408 1.0000012574273538 0.7084535751354568 0.5370988202587342 0.12759054938353315 2.080867199445947e-06 3.2987860587479107e-07 0.12353955112301808 0.04117967274130905 8.360406082517447e-11 10.077772627451727 -0.291547682291897 IK(ub)VAEDEAEAAAAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKVAEDEAEAAAAAK 15 1 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5H0E2;H0YFS2;F5H867 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 1 69392100.0 17363900.0 26306500.0 25721700.0 True False 22477910.8436398 24842520.149727996 21040614.52692939 1.0 1.1051970230924406 0.936057388664432 24.422004618116397 -6.738500016524642 1.6920896109263366 1.0627005765488151 0.935988637164646 0.5982076861001658 0.04420124712536453 0.3205492037998737 1.801476001142975 0.020669792217665683 0.05080749695232063 1.8259966795968972e-07 6.738500016524642 -0.12671193938416914 IK(ub)YPENFFLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKYPENFFLLR 11 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62140;E7ETD8;C9J9S3;C9JP48;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 7510000.0 1002800.0 1942900.0 4564300.0 True False 970966.6629049681 2718710.1020896486 3368772.903935075 1.0 2.800003548994903 3.4695041885951836 19.88906223755057 -9.507474804852466 0.29158744218657845 1.7235263756002802e-16 3.7535158840166383 0.998779000736001 0.03643799432360853 0.8906638119440807 0.11742378347802754 1.0957333520227732 0.2428582099537053 3.108316223276504e-10 9.507474804852466 3.7535158840166383 IK(ub)YPENFFLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKYPENFFLLR 11 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62140;E7ETD8;C9J9S3;C9JP48;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 33403200.0 1898200.0 11062000.0 20443000.0 True False 2879708.177008437 9087899.672199506 16402432.08951479 1.0 3.155840492712842 5.695866067427128 21.457491189007666 -6.968959131036842 0.2819387525255978 0.4533223633104176 8.475990178339174 0.9999730880190678 0.009956272730125466 0.07664188636479988 0.010233543324301715 0.046399462130348505 0.23257736450983962 1.0740904840814364e-07 6.968959131036842 8.022667815028756 IK(ub)YPENFFLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKYPENFFLLR 11 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62140;E7ETD8;C9J9S3;C9JP48;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 9552200.0 1002800.0 2223600.0 6325800.0 True False 833872.6315724402 2211621.025449956 7648495.532805451 1.0 2.652228819741313 9.172258739782146 19.669467512984845 -6.945185815352087 0.6094110141188871 0.927819380964021 11.235867908846618 0.9987672655344657 0.1238721930351952 0.08547842883900617 0.04442044374898355 0.12598353315662597 0.5496721513506634 1.1345252987439255e-07 6.945185815352087 10.308048527882598 IK(ub)YPENFFLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKYPENFFLLR 11 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62140;E7ETD8;C9J9S3;C9JP48;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 31362000.0 1898200.0 7151800.0 22312000.0 True False 2457257.3191159223 6753796.043062544 18251444.94045295 1.0 2.7485098896734352 7.427567637490849 21.228617511100115 -6.9539878247482285 0.5132028716399444 0.9161038894536414 9.466374334266195 0.999478202530239 0.06198265437643731 0.0819229039653269 0.029633183615831508 0.07100344860560771 0.38626234781009056 1.1117628946207592e-07 6.9539878247482285 8.550270444812554 IKAEYEGDGIPTVFVAVAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKAEYEGDGIPTVFVAVAGR 20 1 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 6553430.0 2272200.0 3519000.0 762230.0 False True 2978876.2040161015 2993978.916954566 683361.7514264492 1.0 1.005069936413639 0.2294025345884281 21.506336738711173 -6.905428744584284 0.9263179984381424 1.027624246013369 0.1383804067333277 0.9890787567058257 0.03808821984873535 0.10751865294763673 0.15574459374769284 0.0304950112291296 0.08173689669915857 1.2432866072062478e-07 6.905428744584284 -0.8892438392800415 down IKAEYEGDGIPTVFVAVAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKAEYEGDGIPTVFVAVAGR 20 1 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 186444400.0 34613400.0 90388000.0 61443000.0 False True 52511058.37849745 74257555.1953326 49298764.118576445 1.0 1.4141317560215094 0.938826328032337 25.646117938186997 -6.676425131043004 1.9148257237853719 1.2628649741902183 0.9406922560949788 0.307757156037492 0.17565810375637023 0.446501654566516 3.1620899970439234 0.07369868889715837 0.195253196447091 2.1065650229519148e-07 6.676425131043004 -0.3221727180952395 IKAEYEGDGIPTVFVAVAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKAEYEGDGIPTVFVAVAGR 20 1 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 11345500.0 2272200.0 4353900.0 4719400.0 False True 3112293.743896166 4161530.301578062 3604774.919093989 1.0 1.3371264552838755 1.1582373695168322 21.569546800234065 -10.748033465336508 6.4398850524386235 0.9940944714695009 1.247681912400354 0.7187845839696322 0.07303116344703882 0.006291739733870738 0.0002461698411444423 0.07184849595875241 0.023570706648711092 1.786349919166853e-11 10.748033465336508 0.25358744093085306 IKAEYEGDGIPTVFVAVAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKAEYEGDGIPTVFVAVAGR 20 1 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 114702400.0 34613400.0 43082000.0 37007000.0 False True 44807728.632118374 40684448.82787831 30272105.723885845 1.0 0.9079783793976006 0.6756000950734795 25.417244260279446 -6.955245874157881 0.49793583530365526 1.0047382464642647 0.5688526836103461 0.9995512368128849 0.002891723972009771 0.08144517480455434 0.027755273711941808 0.003404556119127475 0.019167903800742736 1.1085470379117552e-07 6.955245874157881 -0.43588556285391855 IKDFLQGSSCIAGIYNETTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKDFLQGSSCIAGIYNETTK 20 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 12447300.0 1846300.0 4482300.0 6118700.0 False True 2420517.179594636 3813558.3118685554 5485595.618714849 1.0 1.5755138381241367 2.2662907187601626 21.20688390307181 -6.968696524894344 0.2876185899471009 0.8611241193575803 3.0019520357947744 0.9999703558735029 0.002818545867806183 0.07672795237099635 0.010536454502784795 0.012225047961320283 0.06281740359963377 1.0747401539840745e-07 6.968696524894344 2.1408279164371944 IKDFLQGSSCIAGIYNETTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKDFLQGSSCIAGIYNETTK 20 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 11304500.0 1846300.0 3401300.0 6056900.0 False True 2528927.004381434 3251019.3194050076 4626384.965771151 1.0 1.2855330793544175 1.829386517584657 21.2700939645947 -6.96098840945721 0.42127215598805523 0.9762873786088945 2.1591906164521175 0.9998051190583077 0.004802597463572998 0.07934991198850246 0.019840551542862843 0.007041089463827058 0.04525587245896914 1.093985562400069e-07 6.96098840945721 1.182903237843223 IKDLSTVEALQNLK(ub)NLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKDLSTVEALQNLKNLK 17 2 Q9BTT0;E9PPH5;Q9BTT0-3 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 91626600.0 8242700.0 19112900.0 64271000.0 True False 12504778.522088014 15702053.665230693 51567808.67902005 1.0 1.2556842680176319 4.12384822233616 23.575976169718032 -6.924389892789988 0.7914866677142662 0.9461554163736396 4.636531764230887 0.9953160207479745 0.09692299675041204 0.09565720488994596 0.09273031286267767 0.08551325280686202 0.2679687852933946 1.1901730369348005e-07 6.924389892789988 3.6903763478572476 up IKDLSTVEALQNLK(ub)NLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKDLSTVEALQNLKNLK 17 2 Q9BTT0;E9PPH5;Q9BTT0-3 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 101962100.0 8242700.0 15799400.0 77920000.0 True False 10670337.637907932 14920149.501211215 63739359.52671624 1.0 1.3982827917464586 5.973509151226186 23.34710249181048 -6.924032645414073 0.7942374974982125 0.9129543891368385 6.784395433082155 0.995229915733634 0.15584865079273405 0.09585676953443276 0.09373954644828628 0.13723187277175733 0.4283614894737291 1.1911524671083328e-07 6.924032645414073 5.871441043945317 up IKDPDASKPEDWDER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKDPDASKPEDWDER 15 2 P27797;K7EJB9 P27797 CALR Calreticulin 0 87181060.0 1991060.0 47238000.0 37952000.0 False True 2610298.9414524683 40190274.53228177 34025091.10129047 1.0 15.396809114100316 13.034940389761502 21.315783608553836 -9.458300192230304 8.969108563665527 1.0000008225172752 14.215874751814809 0.9766062184052254 0.9642288690119517 0.0 0.0 0.9336105739918005 0.3112035293012235 3.480966211555316e-10 9.458300192230304 13.215873929297533 IKDPDASKPEDWDER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKDPDASKPEDWDER 15 2 P27797;K7EJB9 P27797 CALR Calreticulin 0 88367500.0 22270800.0 8471700.0 57625000.0 False True 21563825.644419566 11854493.989331884 42531283.78705571 1.0 0.5497398367436565 1.9723440769918414 24.362109813944745 -6.821593145515593 1.3649188338744491 0.7576936417070219 2.0044872397056617 0.8880169759980332 0.1986647194698577 0.191420275629459 0.7002864080876422 0.1143631301871248 0.2634895117739233 1.5080191427307853e-07 6.821593145515593 1.2467935979986398 IKDPDASKPEDWDER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKDPDASKPEDWDER 15 2 P27797;K7EJB9 P27797 CALR Calreticulin 0 79509060.0 1991060.0 39545000.0 37973000.0 False True 2727208.688373338 37797771.14217249 29004559.478483703 1.0 13.859508186268366 10.635254867783392 21.378993670076728 -9.686287815953262 8.767074479355793 1.000000020754784 12.247381527026471 0.9419446681338056 1.3162959052939354 0.0 0.0 1.2744980489626039 0.42483267665703434 2.059264743536098e-10 9.686287815953262 11.247381506271687 IKEENFVSPK(ub)EEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKEENFVSPKEEVK 14 2 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 14540700.0 4859200.0 4577600.0 5103900.0 True False 4704947.355791599 6405459.55186865 3767035.4762820606 1.0 1.3614306532003573 0.8006541181900778 22.165747149884087 -6.732675775014024 1.713462976162547 1.2168547122898221 0.8008200429137 0.5716488838339955 0.15190723687309485 0.3312357037160278 1.9063850975776084 0.07022128926920952 0.17372472447012108 1.8506497163263601e-07 6.732675775014024 -0.4160346693761221 IKEENFVSPK(ub)EEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKEENFVSPKEEVK 14 2 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 30806100.0 8680100.0 10630000.0 11496000.0 True False 13168346.30031134 8732993.44743092 9223810.561124202 1.0 0.6631807250713361 0.7004532194681212 23.650570845482594 -10.021313660327372 7.306520315313963 1.0000000224846601 0.6818169725052765 0.989813207348737 0.015216432118811678 5.564520022369719e-09 7.511869915711124e-10 0.014733248143923567 0.004911082348737739 9.52108274873728e-11 10.021313660327372 -0.3181830499793836 IKEIAVTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKEIAVTVK 9 1 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 23151100.0 10235000.0 7726500.0 5189600.0 False True 13418184.115880987 6573736.317661102 4652629.974158329 1.0 0.48991251430816246 0.34674065685622435 23.677686108903732 -13.999999999999998 0.1782320500786624 3.632494139463318 0.23091163997442232 0.9995003768359578 0.006266761610507768 12.18237608094329 0.13381522530988196 11.10169630679102 0.10852534738058649 1.0000000000000041e-14 13.999999999999998 -3.401582499488896 IKEIAVTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKEIAVTVK 9 1 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 12355900.0 5058700.0 2026100.0 5271100.0 False True 4898114.337492381 2835132.295971921 3890440.780389584 1.0 0.5788211749714655 0.7942731656160804 22.223795020687877 -10.283946454742454 4.828208350375733 1.0001093735756164 0.6865471702934627 0.7383680430149853 0.08795790685890219 0.00010359284793080364 1.536355261661881e-05 0.08519446592449953 0.028388292369144946 5.2006011209847166e-11 10.283946454742454 -0.3135622032821537 IKEIAVTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKEIAVTVK 9 1 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 77926000.0 16159000.0 35892000.0 25875000.0 False True 24514384.3811397 29486792.17452403 20760794.908584606 1.0 1.2028363313585753 0.846882164601982 24.54712519652946 -6.752143770162304 1.6420200732490404 1.118961040967606 0.8460615112592017 0.6581235126682785 0.08524337770354987 0.29630869201242505 1.5725202578552444 0.04099958139439154 0.09930862912917134 1.7695230730619027e-07 6.752143770162304 -0.27289952970840436 IKEIAVTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKEIAVTVK 9 1 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 22400800.0 10235000.0 5404500.0 6761300.0 False True 14019156.09047497 5165711.319708461 5164420.193344532 1.0 0.3684751982480742 0.36838310095237414 23.740896170426623 IKEIAVTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKEIAVTVK 9 1 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 10751900.0 5058700.0 3268300.0 2424900.0 False True 4206533.1884079585 3250693.0191932465 2931935.37852919 1.0 0.7727724645442611 0.696995660609262 22.004200296122153 -13.999999999999998 0.1534288282757655 2.10494707095865 0.6168254336798933 0.999555199466367 0.002715342416466672 11.972264059558313 0.12352745043837471 3.940454123705431 0.07251288140037151 1.0000000000000041e-14 13.999999999999998 -1.488121637278757 IKEIAVTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKEIAVTVK 9 1 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 74987000.0 16159000.0 35947000.0 22881000.0 False True 20918144.04150997 33946517.85004744 18716892.778885957 1.0 1.6228264698189265 0.8947683284780977 24.31825151862191 -6.680205077243029 1.9011388027497325 1.3939983642993157 0.8975344530938013 0.3250562479793271 0.263957063943649 0.4380768548255791 3.061432932715694 0.11140007685458105 0.29373520585508844 2.088309781818061e-07 6.680205077243029 -0.49646391120551436 IKGDVDVSVPEVEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKGDVDVSVPEVEGK 15 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7387600.0 1376200.0 3000800.0 3010600.0 False True 1804211.5271397557 2553092.337026783 2699091.9917144007 1.0 1.4150737308913215 1.495995314913719 20.78293706050378 -12.050034794955502 0.26563967570376834 1.64082745300206e-11 1.52658837321442 0.9994044829868978 0.005302018862019404 5.324050042790338 0.15216589661640129 2.95432010655979 0.0343105189975659 8.911795354432147e-13 12.050034794955502 1.5265883731980119 IKGDVDVSVPEVEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKGDVDVSVPEVEGK 15 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 8433100.0 1376200.0 4892400.0 2164500.0 False True 1885018.330406609 4676237.590996699 1653289.6792767996 1.0 2.480738524164913 0.8770682240104136 20.84614712202667 -6.664011922973713 1.9583983056705212 1.949942043329778 0.8836535982986544 0.25294582565933743 0.6298600792368935 0.47497467246331115 3.5059163514166194 0.259450681387517 0.6986966196644797 2.1676445942217876e-07 6.664011922973713 -1.0662884450311236 IKGDVDVSVPEVEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKGDVDVSVPEVEGK 15 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 14629900.0 2808900.0 6724800.0 5096200.0 False True 3636176.4216967225 6350558.9684257135 4168743.8914277623 1.0 1.7464936328536003 1.1464635947126383 21.793990767902493 -10.09817101982798 4.478429695287368 0.9999645731485004 1.4464786135978667 0.42470348048561324 0.24496123739105952 37507884.780546926 42393454.80235732 12198.86544504352 0.08385674809695663 7.976805086341695e-11 10.09817101982798 0.44651404044936627 IKGDVPSVGLEGPDVDLQGPEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKGDVPSVGLEGPDVDLQGPEAK 23 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 11917900.0 3644000.0 1796400.0 6477500.0 False True 3528323.2146247504 2513711.8881022464 4780848.429165351 1.0 0.7124381002519885 1.354991631534474 21.75055129540604 -6.7850265253989654 1.5159808609421879 0.8382365147493469 1.3609348985509948 0.7848570362761392 0.12189697025952946 0.24284868406894639 1.1025619716865234 0.0633078737495809 0.14878425041380056 1.6404895739772135e-07 6.7850265253989654 0.5226983838016479 IKGEHPGLSIGDVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKGEHPGLSIGDVAK 15 1 Q5T7C4;P09429;B2RPK0 Q5T7C4 HMGB1;HMGB1P1 High mobility group protein B1;Putative high mobility group protein B1-like 1 0 23794900.0 5869200.0 2188700.0 15737000.0 False True 5682885.458637654 3062659.3239197186 11615007.600119673 1.0 0.5389268086099915 2.0438574179716293 22.438192206775575 -6.8244674484785 1.3523463515485263 0.7525324811716566 2.0799889674505416 0.8943543661790276 0.2046249988957952 0.18775087172890315 0.6734271177426224 0.11886123689170712 0.27369715619471696 1.4980715332655265e-07 6.8244674484785 1.327456486278885 up IKGGADVSGGVSAPDISLGEGHLSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKGGADVSGGVSAPDISLGEGHLSVK 26 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 27895900.0 8872700.0 12433000.0 6590200.0 False True 11485885.05706452 11741092.620514642 5390851.221162287 1.0 1.0222192336230245 0.4693457399564158 23.453358693608386 -6.8975368851608065 0.9767180183126072 1.024565595337723 0.41413183773696227 0.985300226102985 0.03098367107599411 0.11324077742055502 0.1878257054322824 0.02389795434845213 0.06144386696823838 1.2660857327367677e-07 6.8975368851608065 -0.6104337576007608 down IKPVLMMNK(ub)MDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKPVLMMNKMDR 12 2 P13639 P13639 EEF2 Elongation factor 2 1 7256800.0 1889200.0 2641600.0 2726000.0 True False 2476759.4950388237 2247483.57687615 2443939.6696384316 1.0 0.9074290747155974 0.9867488847963909 21.24002235225616 -10.014800876032401 4.643640049976438 1.0000014081081967 0.947088979753212 0.37236820894640743 0.03238217687491859 4.7207252395672113e-07 1.0011506673993027e-07 0.0313547423848481 0.01045130264453076 9.664939147595352e-11 10.014800876032401 -0.052912428354984664 IKPVLMMNK(ub)MDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKPVLMMNKMDR 12 2 P13639 P13639 EEF2 Elongation factor 2 1 10127600.0 1494200.0 3205900.0 5427500.0 True False 1446767.4388837302 4486032.588547644 4005874.928490157 1.0 3.1007281944421514 2.768845096196618 20.464401603333467 -10.275124509503083 5.466333809966903 0.9997890295256838 2.934786645319467 0.9784083649691262 0.1354907074928783 0.0003483960606075585 4.619965603584233e-05 0.13120167735782892 0.043729437807106315 5.307322648072221e-11 10.275124509503083 1.9349976157937832 IKPVLMMNK(ub)MDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKPVLMMNKMDR 12 2 P13639 P13639 EEF2 Elongation factor 2 1 43488200.0 4630200.0 12791000.0 26067000.0 True False 7024351.912962011 10508346.11346085 20914846.02442805 1.0 1.49598799201245 2.9774769663567056 22.74393369357774 -6.951549174971604 0.5415752463012565 0.9784117749624289 3.5636525869316835 0.9993172788867921 0.02194973477860277 0.08286969414718245 0.03343438332297194 0.024090319751496978 0.12271937991660793 1.118023224143e-07 6.951549174971604 2.5852408119692547 IKPVLMMNK(ub)MDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKPVLMMNKMDR 12 2 P13639 P13639 EEF2 Elongation factor 2 1 12916900.0 1889200.0 1662600.0 9365100.0 True False 2587688.293710339 1589140.834517031 7153256.260288821 1.0 0.614116019452425 2.7643423196200243 21.303232413779053 -6.860489934134301 1.1833462476222425 0.7903791300003624 2.8694022140203685 0.9542286069012285 0.20025550521782937 0.1462921657383408 0.388997178881082 0.1319697068804456 0.30821014474722275 1.3788279103993715e-07 6.860489934134301 2.0790230840200064 up IKPVLMMNK(ub)MDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKPVLMMNKMDR 12 2 P13639 P13639 EEF2 Elongation factor 2 1 9724400.0 1494200.0 3629100.0 4601100.0 True False 1242493.5042835472 3609549.3179800524 5563168.736917254 1.0 2.9050850612385366 4.47742279355023 20.244806878767744 -7.471765044357331 0.21211214595005984 2.481763191832067e-13 6.638392718823225 0.9999397018314773 0.011040674579353803 0.13154695511094108 0.01976178990657538 0.1686543224463997 0.3701144105806403 3.37469832269497e-08 7.471765044357331 6.638392718822977 IKPVLMMNK(ub)MDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKPVLMMNKMDR 12 2 P13639 P13639 EEF2 Elongation factor 2 1 37495200.0 4630200.0 10727000.0 22138000.0 True False 5993885.174887032 10130033.02020916 18109111.155062173 1.0 1.6900612415218785 3.0212642762886226 22.51506001567019 -6.960744488375987 0.4248109748567904 0.9441184096412609 3.81782190059093 0.9997968226274342 0.011957719913677644 0.07943623800554139 0.02015652541141939 0.01727967979626712 0.11067082523068678 1.0946001709279622e-07 6.960744488375987 2.8737034909496693 IKVDFVIPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKVDFVIPK 9 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 32439100.0 9216100.0 10757000.0 12466000.0 False True 12082396.348839344 9152097.530457595 11176137.902315715 1.0 0.7574737052337106 0.9249934847063112 23.526403282593407 -10.062853347896253 5.022395402843957 1.0000031191593548 0.8412335951438158 0.5449649783866323 0.06838966359139886 2.3885958922911792e-06 4.456984907839282e-07 0.06621930796528258 0.022072669011446635 8.652600495529422e-11 10.062853347896253 -0.158769524015539 IKVDFVIPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKVDFVIPK 9 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 22442700.0 6360600.0 3935100.0 12147000.0 False True 6158686.234616414 5506405.951275411 8965336.297811123 1.0 0.8940877553276378 1.4557222037744415 22.55419119866189 -6.857918960468204 1.1961507736603634 0.9428212271313967 1.4818647046313667 0.9510630371047466 0.053901816825942 0.14896537095942652 0.4061804926800132 0.035174191776946265 0.08192718210298455 1.3870146222337442e-07 6.857918960468204 0.53904347749997 IKVDFVIPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKVDFVIPK 9 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 31174600.0 6792600.0 13386000.0 10996000.0 False True 10304870.805577666 10997163.714704623 8822635.780281994 1.0 1.0671811342605328 0.8561617070935631 23.29682308181837 -6.82105715710865 1.3671880510345686 1.0361720194639663 0.8514454150302666 0.8868266626145593 0.029611931036551707 0.19210572056305272 0.7052754575276872 0.017018582922788583 0.03921651634965232 1.509881426942005e-07 6.82105715710865 -0.1847266044336997 IKVDFVIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKVDFVIPK 9 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 30862100.0 9216100.0 10175000.0 11471000.0 False True 12623541.225737793 9725434.855774548 8761786.052660746 1.0 0.7704204930978975 0.6940830545074452 23.589613344116298 -13.999999999999998 0.1538548511835187 2.1172202237960596 0.6137082021195638 0.9995538853513447 0.0027459538417506247 11.974290736084678 0.12371769673313888 3.9956063187633304 0.07273108042609151 1.0000000000000041e-14 13.999999999999998 -1.503512021676496 IKVDFVIPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKVDFVIPK 9 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 17182200.0 6360600.0 5344700.0 5476900.0 False True 5289120.722357063 5315907.040260107 6622094.4676755825 1.0 1.0050644179456558 1.2520218038669553 22.334596474096166 -6.911331959513413 0.8866090705962411 0.9926719884571821 1.2848638470967142 0.9914146778888386 0.010899122014399298 0.10354409732227958 0.1340362220815034 0.008982430896594527 0.02503068753368978 1.226501378013999e-07 6.911331959513413 0.2921918586395321 IKVDFVIPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKVDFVIPK 9 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 31673200.0 6792600.0 17454000.0 7426600.0 False True 8793154.602163536 16482669.556700896 6075035.00335101 1.0 1.8744887702355844 0.6908823145059069 23.06794940391082 -6.7087828265771146 1.7996058616324542 1.5382835222288727 0.6937679490598815 0.45930236675357927 0.3685753556821689 0.3775210731404635 2.382565837116445 0.1630344566798743 0.4147869476929951 1.9553169877149264e-07 6.7087828265771146 -0.8445155731689912 IKVNGK(ub)AGNLGGGVVTIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKVNGKAGNLGGGVVTIER 19 2 P35268;K7ERI7;K7EMH1;K7ELC4;K7EP65;K7EKS7;K7EJT5 P35268 RPL22 60S ribosomal protein L22 1 12224400.0 2269700.0 5991000.0 3963700.0 True False 2938171.3924757196 5657595.583487752 3242347.270996469 1.0 1.9255498838414018 1.1035255735249838 21.48648712446367 -10.166187924344733 4.222180565007073 0.9998556407347333 1.5145377282808825 0.34314276687413836 0.3355900196149384 117565246.58618347 53.009904426408276 177392.37271104244 0.1148813898540527 6.820435020118349e-11 10.166187924344733 0.5146820875461492 IKVVNVELPIEANLVWQLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKVVNVELPIEANLVWQLGK 20 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 17039500.0 0.0 2989500.0 14050000.0 False True 0.0 2823131.6970183 11493044.165174054 0.0 IKYPENFFLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IKYPENFFLLR 11 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62140;E7ETD8;C9J9S3;C9JP48;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 0 38348000.0 11144000.0 14240000.0 12964000.0 False True 14609891.918649517 12115447.507085253 11622609.639469033 1.0 0.8292633220386725 0.7955301588941106 23.800442169594213 -13.999999999931767 0.22798621836750727 2.0678623535123233 0.7788113532899573 0.9995071069223953 0.0019870620719740157 13.229317806757434 0.1511990067369723 6.387787122836964 0.017732508830820018 1.0000000001571133e-14 13.999999999931767 -1.2890510002223659 IKYPENFFLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IKYPENFFLLR 11 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62140;E7ETD8;C9J9S3;C9JP48;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 0 45316200.0 18772000.0 4860200.0 21684000.0 False True 18176093.13527329 6800903.205608177 16004309.893943889 1.0 0.3741674932557459 0.8805142983606996 24.115538796632254 -10.112721446012639 7.3875876325861585 1.0000001038636683 0.6273408958082581 0.41935215437257845 0.20671521756593625 3.5361409792978096e-07 4.2390163111554656e-08 0.20015120244422602 0.0667170495867095 7.713980807272317e-11 10.112721446012639 -0.3726592080554102 IKYPENFFLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IKYPENFFLLR 11 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62140;E7ETD8;C9J9S3;C9JP48;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 0 25096300.0 2679300.0 11629000.0 10788000.0 False True 4064693.9830674888 9553714.092208292 8655747.07145162 1.0 2.350414110387327 2.1294953832955996 21.95471531012887 -10.101230252757686 4.2602725820012175 0.9998173416898392 2.2399547469789898 0.9767460712640496 0.09018969323485247 5807792.639226125 3442624.629417719 9163.224033588383 0.030874330938662514 7.920812762066691e-11 10.101230252757686 1.2401374052891505 IKYPENFFLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IKYPENFFLLR 11 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62140;E7ETD8;C9J9S3;C9JP48;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 0 40828000.0 11144000.0 11834000.0 17850000.0 False True 15264237.955276325 11311134.750195188 13634197.632289615 1.0 0.741021909075082 0.8932118113093709 23.863652231117104 -10.226281144184798 5.223487328450966 1.0000166212030261 0.8171168603831904 0.6581629998882002 0.06213126741318632 1.2027469999362343e-05 1.781602321654437e-06 0.0601638058419277 0.020052780330810555 5.939075630883567e-11 10.226281144184798 -0.18289976081983572 IKYPENFFLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IKYPENFFLLR 11 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62140;E7ETD8;C9J9S3;C9JP48;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 0 32218000.0 18772000.0 6348300.0 7097700.0 False True 15609749.74060415 6314100.447861112 8581796.253943097 1.0 0.4044972246695824 0.5497715464085943 23.89594407206653 -10.221428942035985 8.232268033208111 1.0000002036969133 0.4771343855394847 0.9452712813663757 0.059307993498248814 2.2176329261680254e-07 2.0892762961936478e-08 0.05742474002613369 0.019141572592974616 6.005802660156578e-11 10.221428942035985 -0.5228658181574286 IKYPENFFLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IKYPENFFLLR 11 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62140;E7ETD8;C9J9S3;C9JP48;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 0 24563900.0 2679300.0 12777000.0 9107600.0 False True 3468406.666898795 12065948.718114326 7450110.251867566 1.0 3.478816031945541 2.1479921379948594 21.725841632221318 -10.009896344607093 5.959390508423127 0.999997719251516 2.8134040849704194 0.7122828493188023 0.5433065796146064 1.6464866894543973e-05 2.733351597477521e-06 0.5260549916149831 0.17535144456090968 9.774704912406151e-11 10.009896344607093 1.8134063657189032 ILAAALTECHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILAAALTECHR 11 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 10146700.0 3731200.0 3377500.0 3038000.0 False True 4891639.332992196 2873590.165391881 2723656.9025537586 1.0 0.5874493129554009 0.5567983894854547 22.221886605306093 -13.999999999999998 0.3688546512241121 6.705304013859289 0.5535635259739095 0.9997889336923986 0.0029359899526467453 22.687099806672602 0.1970346272287888 102.29503129996701 0.00859730965341303 1.0000000000000041e-14 13.999999999999998 -6.151740487885379 ILAAALTECHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILAAALTECHR 11 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 4667920.0 2163000.0 855420.0 1649500.0 False True 2094336.7489663393 1196993.6669563702 1217446.4660607097 1.0 0.571538300871217 0.581304065194664 20.99806200156597 -10.631207229699424 6.5247904722464165 1.0016620293131209 0.5764211830329405 0.9996014956340339 0.003986856590120222 9.670907827937545e-05 5.466165906004191e-06 0.0038729847875773105 0.0012867524314377433 2.3377214959054216e-11 10.631207229699424 -0.42524084628018033 ILAAALTECHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILAAALTECHR 11 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 12571300.0 3731200.0 3109800.0 5730300.0 False True 5110725.471888638 2972398.753266602 4376921.159233006 1.0 0.5816001602152521 0.8564187576319846 22.285096666828984 -10.156747698633238 5.208926602474133 1.0000113828851878 0.7190094589234269 0.5822706442349541 0.11219422258372648 1.4831570157454582e-05 2.4011421979726054e-06 0.10863598668830478 0.03621052963385879 6.970313336336357e-11 10.156747698633238 -0.2810019239617608 ILAAALTECHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILAAALTECHR 11 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 8764000.0 3313400.0 3711400.0 1739200.0 False True 4289261.616878462 3504857.3274171986 1422683.445698984 1.0 0.8171237011110274 0.3316849315277605 22.032297882934028 -6.954164527106425 0.5110847811170113 1.0088549985775654 0.11861731438393215 0.9994888677227087 0.006375624559806524 0.08185535018762087 0.029365927722230047 0.0073297956924972376 0.040067383016304865 1.1113106411992071e-07 6.954164527106425 -0.8902376841936332 down ILAAIIMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILAAIIMK 8 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 10171500.0 2947700.0 3798400.0 3425400.0 False True 3864463.2455674103 3231693.526047238 3070972.4667569594 1.0 0.8362593510894515 0.7946698601104318 21.881836614332297 -13.999999999999998 0.19243339110717075 1.8852536221319134 0.7655527984652327 0.9994882496426063 0.0020050225841476126 12.39143754120745 0.13911386625707728 4.116654536140528 0.0280579788704252 1.0000000000000041e-14 13.999999999999998 -1.1197008236666806 ILAAIIMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILAAIIMK 8 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 6827200.0 2722600.0 1706400.0 2398200.0 False True 2636172.553275893 2387774.418758446 1770039.4755421632 1.0 0.9057731884019617 0.671442949871619 21.330013375788454 -6.955574404132962 0.49387192003348507 1.0049527165451393 0.5622612744855047 0.9995692258245801 0.0028670632304752205 0.08132159732921457 0.02727394320865829 0.0034023834339623684 0.019327344282166287 1.1077087744034537e-07 6.955574404132962 -0.4426914420596346 ILAAIIMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILAAIIMK 8 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 15575900.0 3300500.0 6800100.0 5475300.0 False True 5007099.7988706995 5586569.025576204 4393104.555090754 1.0 1.1157295140864174 0.8773750737066544 22.255543780068585 -6.774700851327646 1.5566718003777156 1.065980785998486 0.8757965208358625 0.7481335802145059 0.04884198684926586 0.2588993216163469 1.2387588259366915 0.02472317311768542 0.05859624623098504 1.6799608023311203e-07 6.774700851327646 -0.19018426516262354 ILAAIIMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILAAIIMK 8 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 10530200.0 2947700.0 3257100.0 4325400.0 False True 4037544.348597278 3113190.552210646 3303829.6044092705 1.0 0.7710603979600199 0.8182769820366396 21.94504667585519 -10.634761545926473 6.558886402591459 1.0008258432963246 0.7946686899983301 0.9618539808725561 0.01927608973082323 0.0002336815397890768 1.3012786588547093e-05 0.018736153593756827 0.006221331208956511 2.3186673898912967e-11 10.634761545926473 -0.20615715329799456 ILAAIIMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILAAIIMK 8 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 5226800.0 2722600.0 1057600.0 1446600.0 False True 2263962.5316305594 1051902.498882836 1749077.3716773158 1.0 0.4646289345280069 0.7725734623432964 21.11041865122273 -10.228658590181832 5.694662347603308 1.0000154472238627 0.6186011984356486 0.671622782793527 0.12571782703832513 2.465663768545391e-05 3.339936594802029e-06 0.12173068590340853 0.04057525420339685 5.906652345069931e-11 10.228658590181832 -0.38141424878821406 ILAAIIMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILAAIIMK 8 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 13174000.0 3300500.0 6132400.0 3741100.0 False True 4272562.3125814535 5791126.549187158 3060258.1869275915 1.0 1.355422373158602 0.7162582925744632 22.026670102161034 -6.755789496164734 1.6283844548847437 1.207530754543222 0.7144035746931452 0.6734891030432323 0.1494149420601664 0.29006507009142496 1.5148952832060134 0.07243266405713683 0.17479396858677454 1.754730819029541e-07 6.755789496164734 -0.4931271798500767 ILAAILHLGNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILAAILHLGNLK 12 0 K7EIG7;O94832;J3QRN6;J3KRL0 K7EIG7 MYO1D Unconventional myosin-Id 0 3118360.0 1044400.0 1556200.0 517760.0 False True 1369218.5139839866 1324021.0260200878 464187.1619046201 1.0 0.9669903032260434 0.33901613012373344 20.38492127441844 -6.917783787962461 0.8410073688708183 1.0149935155571703 0.24274018380373452 0.9935426127420317 0.02443755553426256 0.09949353649312832 0.11250351882140433 0.02081194915046435 0.06107934372758642 1.208415290839539e-07 6.917783787962461 -0.7722533317534358 down ILAAILHLGNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILAAILHLGNLK 12 0 K7EIG7;O94832;J3QRN6;J3KRL0 K7EIG7 MYO1D Unconventional myosin-Id 0 9791800.0 5623600.0 2836100.0 1332100.0 False True 5445081.896203007 3968569.5200661165 983183.0478566069 1.0 0.7288355980161658 0.1805635005310398 22.376522317138242 -7.188723298702869 0.5136869407919655 1.0090817406315362 4.205575393220327e-14 0.9990493369096833 0.010509367279549398 0.08617488301507212 0.03874785252679974 0.011544162966111627 0.048194683259043275 6.475550599875475e-08 7.188723298702869 -1.0090817406314943 down ILAAILHLGNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILAAILHLGNLK 12 0 K7EIG7;O94832;J3QRN6;J3KRL0 K7EIG7 MYO1D Unconventional myosin-Id 0 11606300.0 1044400.0 4372700.0 6189200.0 False True 1430542.9038487603 4179499.655414783 4727438.430575175 1.0 2.921617830664272 3.3046463813538085 20.44813133594133 -10.036002305293238 0.3836893836369431 2.839394387816301e-25 3.356650665775524 0.9988946754867996 0.03352364973750222 1.38369265069382 0.1724948223897939 1.6525095412156532 0.10184044281249004 9.204446858966151e-11 10.036002305293238 3.356650665775524 ILAAILHLGNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILAAILHLGNLK 12 0 K7EIG7;O94832;J3QRN6;J3KRL0 K7EIG7 MYO1D Unconventional myosin-Id 0 9363700.0 5623600.0 1208300.0 2531800.0 False True 4676272.567721152 1201790.6480712278 3061187.6742794355 1.0 0.2569975617689211 0.6546213100172683 22.15692759257252 -10.75864333908333 6.774674551954354 1.012607767125218 0.45580943589714973 0.714077078749275 0.1623292154702212 0.030449639462722052 0.0010848072283342013 0.1548243774925768 0.05239152900992349 1.7432379060752156e-11 10.75864333908333 -0.5567983312280683 ILAGILHLGNVGFTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILAGILHLGNVGFTSR 16 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 0 17492800.0 4121400.0 9000600.0 4370800.0 False True 5403195.311694378 7657745.564064014 3918551.5436741193 1.0 1.4172624016551856 0.7252285578485423 22.365381401968794 -6.743460252159513 1.6740156519738643 1.2472755293430307 0.7245103862310768 0.6203242093753877 0.1753094675595249 0.3116191987710716 1.71591116092362 0.08280323965065527 0.20242601618543618 1.8052599519894196e-07 6.743460252159513 -0.5227651431119539 ILAGILHLGNVGFTSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILAGILHLGNVGFTSR 16 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 0 82218000.0 26779000.0 25770000.0 29669000.0 False True 25928915.30308351 36060095.38877463 21897798.849078618 1.0 1.3907290361847997 0.8445320057979632 24.628058518702236 -6.714688651060221 1.778766914241023 1.239054660464238 0.8456444796068119 0.4872408759263659 0.16453574346469063 0.36571380621785426 2.258433851488182 0.07353702384976403 0.18574496079832387 1.9289072655679456e-07 6.714688651060221 -0.3934101808574262 ILAGILHLGNVGFTSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILAGILHLGNVGFTSR 16 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 0 202566400.0 71454800.0 61363000.0 69748600.0 False True 108402155.64561296 50412293.21869274 55962758.63810266 1.0 0.46504880754862493 0.516251344863062 26.69181820498177 -10.514172127855568 9.678823114590513 1.0000101105365928 0.4906500769236001 0.9924780115080005 0.0209033483260311 4.560621125493525e-06 2.2894244330378512e-07 0.020239980683003297 0.0067465266622242686 3.060750098522172e-11 10.514172127855568 -0.5093600336129928 ILAGILHLGNVGFTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILAGILHLGNVGFTSR 16 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 0 114829500.0 4121400.0 31415700.0 79292400.0 False True 5645192.956647154 30027650.49617267 60565168.19823867 1.0 5.319153964580686 10.728626756136624 22.428591463491685 -6.968081057931375 0.30050701538081726 0.06745139532591196 16.149953312821044 0.9999633080129574 0.024108421451789906 0.07693039088247404 0.01124694975099762 0.08951984673264804 0.48489130309242007 1.0762643179134473e-07 6.968081057931375 16.082501917495133 ILAGILHLGNVGFTSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILAGILHLGNVGFTSR 16 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 0 80595300.0 26779000.0 21349700.0 32466600.0 False True 22267925.010848 21234684.928516332 39255215.95140242 1.0 0.953599624490009 1.7628591766982744 24.408463794136512 -6.89330661691604 1.0025973673975135 0.959901356570695 1.8371502605340553 0.9829323368499714 0.04847332977879218 0.11650203924862643 0.20649512216139498 0.03666860073191237 0.09257536802364758 1.2784783649728066e-07 6.89330661691604 0.8772489039633603 ILAGILHLGNVGFTSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILAGILHLGNVGFTSR 16 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 0 170164900.0 71454800.0 52959200.0 45750900.0 False True 92499647.18468256 50011973.9651217 37424705.64387625 1.0 0.5406720510540868 0.40459295557263025 26.46294452707422 -13.999999999999998 0.17051342102897565 3.3195335463437656 0.28520936976122535 0.9995127076975767 0.0056231950601169384 12.09655558113102 0.1307726900840315 9.281157565981125 0.11042710746289754 1.0000000000000041e-14 13.999999999999998 -3.0343241765825404 ILAGK(ub)QKPNLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILAGKQKPNLGK 12 2 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 9996400.0 1667200.0 4530800.0 3798400.0 True False 1386350.6694830211 4506391.681106609 4592627.878182723 1.0 3.2505424351164134 3.3127461754646412 20.402860794429415 -10.477579674614256 0.6930400322930232 9.591393115587972e-20 3.3022005555443044 0.9999184734756891 0.009714312821526435 1.88013665208619 0.3498892797104156 3.4240390890082297 0.009748473414233034 3.3298166869405874e-11 10.477579674614256 3.3022005555443044 ILAGLGFDPEMQNRPTQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILAGLGFDPEMQNRPTQK 18 1 Q8NE71-2;Q8NE71;H0YGW7 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 26735000.0 15399000.0 7656400.0 3679600.0 False True 12804950.79136817 7615153.453523591 4448987.34745186 1.0 0.5947038436615448 0.34744275241189737 23.610198372969993 -8.751766615637132 0.173050259114015 1.407748589294234 7.680664304136349e-08 0.9997870341732765 0.003925561299386665 0.29166275311626166 0.04985073073437351 0.20940526729613065 0.14666463990585266 1.7710604481247729e-09 8.751766615637132 -1.407748512487591 down ILAHLWHLGYSPEDIIGNIFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILAHLWHLGYSPEDIIGNIFR 21 0 P35250;P35250-2;A0A087WVY3;H7C5P4 P35250 RFC2 Replication factor C subunit 2 0 3823415100.0 1388615100.0 1188400000.0 1246400000.0 False True 2106630628.0620544 976320734.9884193 1000048493.6834723 1.0 0.4634513150919878 0.47471468436943953 30.9722902313696 -9.953971246249397 5.074197753913935 1.0000024906659706 0.4690829997236971 0.9996625582913404 0.00459825127930268 6309004.894595204 1.0618783258664821 192.67123840392938 0.0015741037151205887 1.1118053352052376e-10 9.953971246249397 -0.5309194909422734 ILAHLWHLGYSPEDIIGNIFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILAHLWHLGYSPEDIIGNIFR 21 0 P35250;P35250-2;A0A087WVY3;H7C5P4 P35250 RFC2 Replication factor C subunit 2 0 3375788800.0 1388615100.0 788160000.0 1199013700.0 False True 1797589620.6458178 744298203.151678 980805509.5194852 1.0 0.4140534605914529 0.5456225927512379 30.743416553462048 -9.950199758907033 7.058343595175689 1.0000000202436012 0.47983802667174763 0.9542134799736517 0.05371287328204993 1.713464288154388e-08 2.5252781163334922e-09 0.052007268249480834 0.017335755308193514 1.121502487254299e-10 9.950199758907033 -0.5201619935718536 ILAK(ub)LPIEPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILAKLPIEPR 10 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 11881100.0 4448100.0 4449400.0 2983600.0 True False 5831502.17546168 3785566.863625361 2674885.692712111 1.0 0.6491580985006934 0.45869582351657795 22.475436134042543 -11.305816476730595 0.10237284892536352 2.074279252776934 2.67476469218829e-13 0.999873820927931 0.0025183791146648825 3.950811334752126 0.06575710858152202 1.2839536341444513 0.3112629474007898 4.9451961592208365e-12 11.305816476730595 -2.0742792527766665 ILAK(ub)LPIEPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILAKLPIEPR 10 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 29991900.0 9753500.0 6989400.0 13249000.0 True False 14796772.576362766 5742086.961568554 10630329.342757002 1.0 0.3880634734321254 0.7184221618529513 23.818779198455246 -10.623875101306714 6.717164804632287 1.0013291641271693 0.5532428176425951 0.7091696218623831 0.13486836978768613 0.00269142858546552 0.000150705254600851 0.1309188073497034 0.043528579176487635 2.3775239401134377e-11 10.623875101306714 -0.44808634648457424 ILAK(ub)LPIEPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILAKLPIEPR 10 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 16092200.0 4492600.0 8503300.0 3096300.0 True False 3735795.9559257547 8457491.035127098 3743722.0143263373 1.0 2.2639060416861754 1.0021216518498581 21.832984228490318 -6.64578508047622 2.023677909773348 1.822861314604882 1.0074156526677676 0.17716111674244917 0.5400099090764322 0.518893426385054 4.068200929631013 0.21678361559960624 0.5980092399263055 2.2605541750213767e-07 6.64578508047622 -0.8154456619371144 ILAK(ub)LPIEPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILAKLPIEPR 10 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 29443300.0 9753500.0 7117800.0 12572000.0 True False 12626098.020228194 6721688.17295094 10284024.999613406 1.0 0.532364643627997 0.8145053985116726 23.589905520547696 -10.335171344071924 5.8701792572505855 1.0000408607395874 0.6734350210698348 0.6410968141058915 0.11518348085144701 6.160310309511167e-05 6.977120172490761e-06 0.11153984561221121 0.03717530859132087 4.621986322057374e-11 10.335171344071924 -0.32660583966975265 ILALCMGNHELYMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILALCMGNHELYMR 14 0 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4 P26038;A0A2R8Y5S7 MSN;RDX Moesin;Radixin 0 12864850.0 5409200.0 6672500.0 783150.0 False True 7091513.58276732 5676989.009201295 702117.1505052587 1.0 0.8005327696186918 0.0990080808998848 22.75766215240286 -7.149047888519313 0.6991498652945145 0.9983425406297268 3.3608186849555783e-26 0.996923658444675 0.021431317064639594 0.0823700801682596 0.06902620546736513 0.019912637526505694 0.054328543306162304 7.094995289881033e-08 7.149047888519313 -0.9983425406297268 down ILALCMGNHELYMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILALCMGNHELYMR 14 0 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4 P26038;A0A2R8Y5S7 MSN;RDX Moesin;Radixin 0 42452600.0 30456000.0 9282900.0 2713700.0 False True 29489190.950771537 12989610.379683984 2002900.5607450458 1.0 0.4404871738044116 0.0679198206586486 24.813682906166253 -8.281914520188348 0.4256661089247934 1.0678670700183044 3.70138316109745e-23 0.9962660038100999 0.023407605310954798 0.12202221357119472 0.11888713650091048 0.06783687503000678 0.0793862018929407 5.224990195082015e-09 8.281914520188348 -1.0678670700183044 ILALCMGNHELYMR ddPTM_RPMI8226_Bortezomib_8h_R1 3 ILALCMGNHELYMR 14 0 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4 P26038;A0A2R8Y5S7 MSN;RDX Moesin;Radixin 0 658491000.0 229896000.0 208762000.0 219833000.0 False True 348769039.64889526 171506790.03504917 176382911.1937731 1.0 0.4917488955089148 0.505729841649182 28.37769673634829 -9.90261706349876 5.690804764095482 1.000000285148788 0.4987393686001137 0.999416884853673 0.005707697363876263 2.0648757304087118e-08 3.98671419330824e-09 0.005526457377959588 0.0018421514025136906 1.2513619246289218e-10 9.90261706349876 -0.5012609165486742 ILALCMGNHELYMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ILALCMGNHELYMR 14 0 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4 P26038;A0A2R8Y5S7 MSN;RDX Moesin;Radixin 0 55787720.0 8757120.0 16836100.0 30194500.0 False True 11994863.916269671 16092225.432462491 23063180.975247536 1.0 1.3415929972023455 1.9227547003651246 23.515913454320035 -6.9630800686414105 0.389601062982415 0.9641481366731717 2.3210679417054885 0.9998679345260444 0.004377536686962193 0.07861865622247727 0.01719580295647125 0.007505163379477761 0.048894579680065435 1.0887293513945351e-07 6.9630800686414105 1.3569198050323168 ILALCMGNHELYMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILALCMGNHELYMR 14 0 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4 P26038;A0A2R8Y5S7 MSN;RDX Moesin;Radixin 0 55161600.0 30456000.0 5443600.0 19262000.0 False True 25325513.429567438 5414274.24633 23289595.142574664 1.0 0.2137873437941383 0.9196099896393078 24.59408818160053 -10.89519815874174 10.299853821702639 1.036086634044189 0.5666986667170725 0.33443826195788695 0.2881508885369711 0.1493482395807508 0.0015196278373725517 0.1745043560915275 0.09300029937487987 1.272922142931347e-11 10.89519815874174 -0.4693879673271165 ILALCMGNHELYMR ddPTM_RPMI8226_Carfilzomib_8h_R1 3 ILALCMGNHELYMR 14 0 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4 P26038;A0A2R8Y5S7 MSN;RDX Moesin;Radixin 0 614702000.0 229896000.0 206271000.0 178535000.0 False True 297604903.9276553 194791837.52321842 146043461.92379725 1.0 0.6545316792581157 0.4907293528983613 28.14882305844074 -13.99999999997575 0.09917821869239585 2.7103011240831134 0.13736021586657501 0.999797827278691 0.0030182417261437554 12.086736159918887 0.0936198764989894 4.239934244947121 0.3153102256202438 1.0000000000558395e-14 13.99999999997575 -2.5729409082165384 ILALQLCGWIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILALQLCGWIK 11 0 Q9NXC5;Q9NXC5-2 Q9NXC5 MIOS WD repeat-containing protein mio 0 8335600.0 3420700.0 4914900.0 0.0 False True 5189451.98666778 4037797.6947110323 0.0 1.0 0.7780778596823975 0.0 22.30715076535235 -7.285980162463595 0.827830800539324 0.9889875088842729 6.6137449331941696e-18 0.988431479083693 0.04611809232989642 0.10239230338102344 0.13755647347994512 0.03925112365873533 0.06935760124914754 5.176304755364608e-08 7.285980162463595 -0.9889875088842729 down ILALQLCGWIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILALQLCGWIK 11 0 Q9NXC5;Q9NXC5-2 Q9NXC5 MIOS WD repeat-containing protein mio 0 10988700.0 3420700.0 3550300.0 4017700.0 False True 4428163.58207768 3352722.684035476 3286519.8250832637 1.0 0.7571361404996672 0.7421857309844997 22.0782770874448 -13.999999999999998 0.3965446288796236 5.004103105923033 0.7412360881605989 0.9998328227152546 0.0015278755332675178 26.266426144903807 0.2071377773352486 90.37558837249972 0.0038624011644615096 1.0000000000000041e-14 13.999999999999998 -4.262867017762434 ILAQATSDLVNAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILAQATSDLVNAIK 14 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 6888940.0 2572800.0 963540.0 3352600.0 False True 2491127.872279516 1348286.5467947216 2474453.4841558915 1.0 0.5412353824940215 0.9933064904820135 21.248367647895556 -10.911429427136072 10.590135548445476 1.0268457937764035 0.7672709364880175 0.2611023414390653 0.18455725700420214 0.09138611867050885 0.0007643062794494426 0.13960021654288687 0.059565598566583076 1.2262261482678528e-11 10.911429427136072 -0.25957485728838603 ILATGANVILTTGGIDDMCLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 ILATGANVILTTGGIDDMCLK 21 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 105409000.0 28433700.0 44331000.0 32644300.0 False True 43136001.6819118 36419786.69031609 26192139.796495035 1.0 0.8443014018517155 0.6071990628532958 25.362389122095934 -6.965005010130477 0.357966938458966 1.0209115338760792 0.42248931589228317 0.9999132467701064 0.001504260880261885 0.0779592681420178 0.014853990563343614 0.0031945583877009062 0.020276438718703903 1.0839144096395725e-07 6.965005010130477 -0.5984222179837961 ILATGANVILTTGGIDDMCLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ILATGANVILTTGGIDDMCLK 21 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 70586200.0 28433700.0 23682800.0 18469700.0 False True 36807985.162020095 22364831.361145686 15108404.115125647 1.0 0.6076081389052119 0.41046539354496053 25.133515444188383 -12.145549920760509 0.1081634021686779 2.329558954679378 4.20720948534822e-14 0.9998161217463734 0.003322737228475211 5.952732374359396 0.07964678443944004 2.1045096789885256 0.31109857235192445 7.152371751262344e-13 12.145549920760509 -2.3295589546793356 ILATPPQEDAPSVDIANIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILATPPQEDAPSVDIANIR 19 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 38944020.0 956020.0 20897000.0 17091000.0 False True 1253351.4781108503 17779249.055868007 15322587.268448446 1.0 14.185365690609219 12.225291577063324 20.257359616562624 -9.58440463125245 8.444361661665047 0.9999918440651299 13.205328633836341 0.9810247606172778 0.8001969060516462 0.0 0.0 0.7747873226998279 0.25826244089994255 2.6037265330340695e-10 9.58440463125245 12.205336789771211 ILATPPQEDAPSVDIANIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILATPPQEDAPSVDIANIR 19 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 36339000.0 14878000.0 4335000.0 17126000.0 False True 14405706.033805465 6065988.10672635 12640186.831012884 1.0 0.421082319220694 0.8774430632799609 23.780137033942815 -9.959756839035947 6.849181083218292 1.0000000263128672 0.6492626912503385 0.4405796129248942 0.18630849359701762 7.476003619991265e-08 1.138145593515271e-08 0.1803924366798096 0.060130807746519244 1.0970922848792562e-10 9.959756839035947 -0.3507373350625287 ILATPPQEDAPSVDIANIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILATPPQEDAPSVDIANIR 19 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 33237020.0 956020.0 19147000.0 13134000.0 False True 1309486.4294690667 18301022.229338113 10032019.703220831 1.0 13.97572499988281 7.661033728534575 20.320569678085516 -9.764194445122527 10.945049682473615 1.0000000076742523 10.81838080857942 0.7632239040363623 2.5779619163352647 0.0 0.0 2.496100929476027 0.8320336307604083 1.7210978214541003e-10 9.764194445122527 9.818380800905167 ILCLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILCLFR 6 0 H0Y8X4;O43598;O43598-2 H0Y8X4 DNPH1 2-deoxynucleoside 5-phosphate N-hydrolase 1 0 10517400.0 3149500.0 3463200.0 3904700.0 False True 4129024.999801386 2946504.0594478687 3500679.100527209 1.0 0.7136077063204028 0.8478222100121938 21.977369722878297 -10.064456019078763 4.630459705683053 1.0000099444937502 0.7807149581608732 0.7806654249943891 0.05479284171253625 76012656.74425393 1.4976110595722947 8274.381355927966 0.018757047118621344 8.620728762448817e-11 10.064456019078763 -0.21929498633287703 ILCLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILCLFR 6 0 H0Y8X4;O43598;O43598-2 H0Y8X4 DNPH1 2-deoxynucleoside 5-phosphate N-hydrolase 1 0 12608100.0 3149500.0 4080900.0 5377700.0 False True 4313955.26203722 3900592.344268344 4107598.017208062 1.0 0.9041800638484901 0.9521651866339225 22.04057978440119 -10.233614956666312 4.6753391888896925 1.0000187577164297 0.9281726252408975 0.7492152414732884 0.01958984434590914 3.83123384097723e-06 6.280196777871174e-07 0.0189727378748183 0.006322595075392168 5.83962613186004e-11 10.233614956666312 -0.07184613247553218 ILCLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILCLFR 6 0 H0Y8X4;O43598;O43598-2 H0Y8X4 DNPH1 2-deoxynucleoside 5-phosphate N-hydrolase 1 0 6918090.0 4787600.0 760790.0 1369700.0 False True 3981101.52664162 756691.4732650078 1656097.9372227427 1.0 0.1900708806849591 0.415989877711005 21.924736233045497 -10.209452496014446 5.039696320368098 1.0000722925183614 0.3030303792150006 0.9269538730444535 0.0922310443212793 7.492430747128017e-05 1.1752975173720461e-05 0.08931152366798564 0.029767441554670645 6.17372817649964e-11 10.209452496014446 -0.6970419133033607 ILCLFRPQSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILCLFRPQSGR 11 1 H0Y8X4;O43598;O43598-2 H0Y8X4 DNPH1 2-deoxynucleoside 5-phosphate N-hydrolase 1 0 89938000.0 29012000.0 26337000.0 34589000.0 False True 38035012.952607684 22407622.26082194 31010062.081116553 1.0 0.5891314481407497 0.8153030503698172 25.180824760562444 -10.104855155405895 5.209057015598245 1.0000064720073922 0.7022172492549054 0.6980063975363169 0.0923341699628095 6.940213896613338e-06 1.1925960638856657e-06 0.08940411745681831 0.02980072521246385 7.85497567722868e-11 10.104855155405895 -0.29778922275248687 ILCLFRPQSGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILCLFRPQSGR 11 1 H0Y8X4;O43598;O43598-2 H0Y8X4 DNPH1 2-deoxynucleoside 5-phosphate N-hydrolase 1 0 70506900.0 50129000.0 10709000.0 9668900.0 False True 48537682.33422724 14985159.546697237 7136325.029217592 1.0 0.30873249042899137 0.14702648923525716 25.532601885911426 -13.999999999999961 0.20409163273655961 4.903955398483854 0.046141894928351065 0.9994875609737326 0.00837390692772338 12.614794292282857 0.14322754439951277 19.69391285767171 0.09991098820600842 1.00000000000009e-14 13.999999999999961 -4.857813503555502 ILCLFRPQSGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILCLFRPQSGR 11 1 H0Y8X4;O43598;O43598-2 H0Y8X4 DNPH1 2-deoxynucleoside 5-phosphate N-hydrolase 1 0 64890000.0 30160000.0 18880000.0 15850000.0 False True 45754924.99134685 15510716.489886697 12717240.55269822 1.0 0.3389955615230508 0.27794255055829065 25.44742370549191 -13.999999999999998 0.3370273342087021 8.508071693498879 0.26799980427610937 0.999729235897366 0.005379803110645618 19.43457075786588 0.18604295544461263 103.80217904458705 0.019065857114348914 1.0000000000000041e-14 13.999999999999998 -8.240071889222769 ILCLFRPQSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILCLFRPQSGR 11 1 H0Y8X4;O43598;O43598-2 H0Y8X4 DNPH1 2-deoxynucleoside 5-phosphate N-hydrolase 1 0 132420000.0 29012000.0 48154000.0 55254000.0 False True 39738520.419820264 46026397.05601655 42204143.19185044 1.0 1.1582312720697094 1.0620461644264039 25.244034822085336 -10.083160362009934 4.034227190800879 0.9999783107219073 1.1101387182276061 0.6361318439260201 0.039267405941404494 5369008.304782594 4477025.971488174 890.8775095571649 0.013442277611261572 8.25732993704558e-11 10.083160362009934 0.11016040750569878 ILCLFRPQSGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILCLFRPQSGR 11 1 H0Y8X4;O43598;O43598-2 H0Y8X4 DNPH1 2-deoxynucleoside 5-phosphate N-hydrolase 1 0 74339600.0 50129000.0 9578600.0 14632000.0 False True 41684484.591239326 9526998.180596769 17691483.549275897 1.0 0.22855022135979638 0.4244141128949943 25.313007161345702 -10.374094375857856 5.027043058331572 1.0004807226400703 0.3264821671307496 0.9403563404273614 0.07996109888316388 43485579.53491128 89741525.41357188 179799.2660528253 0.027372575674422826 4.225767747860552e-11 10.374094375857856 -0.6739985555093206 ILCLFRPQSGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILCLFRPQSGR 11 1 H0Y8X4;O43598;O43598-2 H0Y8X4 DNPH1 2-deoxynucleoside 5-phosphate N-hydrolase 1 0 86316000.0 30160000.0 31686000.0 24470000.0 False True 39042714.54248042 29922646.245767433 20016711.083402798 1.0 0.7664079354218597 0.5126874838998098 25.21855002758436 -6.970067717907638 0.2565622304651606 1.0742895457375339 0.19731190646602592 0.9999829057672968 0.0008227530675926039 0.07628072015584823 0.008951424687272632 0.005416429295735788 0.024064490196966843 1.0713522402815095e-07 6.970067717907638 -0.876977639271508 ILDDIFASLVQNK(ub)TTSDLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILDDIFASLVQNKTTSDLSK 20 1 Q9Y4C1 Q9Y4C1 KDM3A Lysine-specific demethylase 3A 1 10087500.0 4011500.0 2421900.0 3654100.0 True False 3884157.1282840865 3388977.300041652 2696981.5893497705 1.0 0.8725129257422211 0.6943543992364755 21.889170133523862 -6.966407246484065 0.3330185066344063 1.020955459353101 0.5400531886593789 0.9999392805604285 0.0009767404266344218 0.07748662064143942 0.013193630015945902 0.0025723946844058224 0.015502154591124303 1.0804203447092254e-07 6.966407246484065 -0.48090227069372204 ILDDIFASLVQNK(ub)TTSDLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILDDIFASLVQNKTTSDLSK 20 1 Q9Y4C1 Q9Y4C1 KDM3A Lysine-specific demethylase 3A 1 9291400.0 4011500.0 3030800.0 2249100.0 True False 3335739.9895820157 3014472.478833301 2719376.4113365486 1.0 0.9036892828121862 0.8152243339797295 21.66957540895814 -6.9721420239359935 0.20052591058442892 1.05230046229548 0.6641692417119677 0.9999946178587535 0.00017496083068885114 0.07561355816059903 0.006478891349851345 0.002859774842312493 0.00937917822245245 1.066247377649011e-07 6.9721420239359935 -0.38813122058351224 ILDELVK(ub)SLNFAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILDELVKSLNFAR 13 1 Q9NS91;F8WE49;C9J0Q4 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 13635600.0 2252800.0 2917200.0 8465600.0 True False 2916294.0093269213 2754855.255575109 6924947.664391281 1.0 0.9446424972120446 2.3745711654050803 21.47570474317827 -6.897894568123467 0.9744950321431828 0.9370658182500865 2.5184038805204287 0.9854890142610163 0.0796748564315429 0.11297124890040966 0.18629472427481317 0.06155600149659656 0.15852946499903406 1.2650434195591657e-07 6.897894568123467 1.5813380622703423 up ILDK(ub)CNEIINWLDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILDKCNEIINWLDK 14 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 51774000.0 17630000.0 19507000.0 14637000.0 True False 26745998.92564474 16025823.44111334 11743990.534374991 1.0 0.5991858253515211 0.43909335998344623 24.67281975154343 -13.999999999999462 0.12658563420049582 2.9048186203403477 0.20486056106314748 0.9996613358154021 0.004341477795591266 11.9433192577141 0.11028983556268501 5.679024577038297 0.20808274974908192 1.0000000000012393e-14 13.999999999999462 -2.6999580592772 ILDK(ub)CNEIINWLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILDKCNEIINWLDK 14 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 41871600.0 17630000.0 15519000.0 8722600.0 True False 22822382.539254975 14655354.007702608 7135176.301433967 1.0 0.6421482937855016 0.3126394139245241 24.44394607363588 -7.479989988887725 0.26856950108635147 1.1128462636194913 1.5761532539948592e-12 0.999830759137421 0.0036516076424690886 0.12411410914792646 0.025973780770687564 0.02390252886826445 0.06341208382830403 3.311387546190478e-08 7.479989988887725 -1.1128462636179153 down ILDKLEDYQQK(ub)VDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILDKLEDYQQKVDK 14 2 Q12769 Q12769 NUP160 Nuclear pore complex protein Nup160 1 5617600.0 1278400.0 2535700.0 1803500.0 True False 1675994.780043211 2157383.4440811854 1616891.1203935838 1.0 1.2872256344530877 0.9647351767717895 20.676586225033574 -6.671756762011709 1.9308833798109195 1.1830527650713578 0.9660200255985151 0.28699116094425403 0.12195714026836824 0.45708009107070696 3.286997507292533 0.05081505100766402 0.13546778900311404 2.1293312997853667e-07 6.671756762011709 -0.21703273947284274 ILDKLEDYQQK(ub)VDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILDKLEDYQQKVDK 14 2 Q12769 Q12769 NUP160 Nuclear pore complex protein Nup160 1 21143800.0 4190800.0 7402500.0 9550500.0 True False 6357749.98851911 6081466.039003519 7662839.488867149 1.0 0.9565437536841639 1.2052753730022072 22.600084854529943 -6.86182234097664 1.1765754011296696 0.9763008976853659 1.2177414997552258 0.9558127184752203 0.02280146375884746 0.1449314645916572 0.3802231235724227 0.015104191063095204 0.035331211249379435 1.374604176242709e-07 6.86182234097664 0.24144060206985996 ILDKLEDYQQK(ub)VDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILDKLEDYQQKVDK 14 2 Q12769 Q12769 NUP160 Nuclear pore complex protein Nup160 1 4940810.0 1278400.0 831510.0 2830900.0 True False 1751059.0274609884 794771.1387641368 2162299.724215612 1.0 0.45388026691284306 1.234852560824815 20.739796286556466 -6.7186938764984445 1.763841725574586 0.6672899152787 1.2335615385477063 0.5064314161776813 0.2298464687272888 0.35785811032320064 2.175094581418517 0.10349284280951758 0.2602227356182053 1.911199941733554e-07 6.7186938764984445 0.5662716232690064 ILDKLEDYQQK(ub)VDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILDKLEDYQQKVDK 14 2 Q12769 Q12769 NUP160 Nuclear pore complex protein Nup160 1 5783200.0 2384200.0 1694900.0 1704100.0 True False 1982567.9379686972 1685769.2372886909 2060419.4311318388 1.0 0.8502958234136981 1.039268007755087 20.91893887388705 -6.6955910954753195 1.846803125604872 0.9066410367389843 1.0386583421312898 0.3966434748691364 0.06324427506946026 0.4047349968449433 2.6805850338076276 0.02735420784992711 0.07072767232361978 2.0156211395399751e-07 6.6955910954753195 0.1320173053923055 ILDLCVLFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILDLCVLFGK 10 0 Q9H1I8;Q9H1I8-3;B1AH59;Q9H1I8-2 Q9H1I8 ASCC2 Activating signal cointegrator 1 complex subunit 2 0 22509900.0 7917200.0 9023000.0 5569700.0 False True 12010971.224850489 7412775.152979218 4468846.353713767 1.0 0.6171670062486135 0.3720636966033023 23.517849478421034 -8.502881022121542 0.16965403128671394 1.3765584740354784 3.8620803093305866e-14 0.9998418669389095 0.0032494152969422146 0.15590610789680348 0.04237946054125559 0.161786210538921 0.1379604738248331 3.1413691751027247e-09 8.502881022121542 -1.3765584740354397 down ILDLCVLFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILDLCVLFGK 10 0 Q9H1I8;Q9H1I8-3;B1AH59;Q9H1I8-2 Q9H1I8 ASCC2 Activating signal cointegrator 1 complex subunit 2 0 15952100.0 7917200.0 4002300.0 4032600.0 False True 10248971.471343685 3779568.4866955434 3298708.177970173 1.0 0.3687753934395551 0.3218574846455005 23.288975800513484 -13.999999999999998 0.3687909443977525 9.725928765514825 0.3169009278328773 0.9997888243663423 0.004493466907499239 22.679208891438485 0.19700749331160894 156.36848376700675 0.013162415184631522 1.0000000000000041e-14 13.999999999999998 -9.409027837681947 ILDSAPTGIK(ub)HDGTMCDTCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILDSAPTGIKHDGTMCDTCR 20 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 26558100.0 9208600.0 10466000.0 6883500.0 True False 12072563.776209245 8904513.596148467 6171261.451194469 1.0 0.7375826511429259 0.5111806875152604 23.52522874912428 -6.972847758267793 0.17743146979522906 1.181092954965339 0.061563597367336444 0.9999969217469107 0.0003503954991241024 0.07538900257197803 0.005579551294407594 0.00891984112101908 0.025608908427921653 1.0645161184643978e-07 6.972847758267793 -1.1195293575980025 ILDSAPTGIK(ub)HDGTMCDTCR ddPTM_RPMI8226_Bortezomib_8h_R1 2 ILDSAPTGIKHDGTMCDTCR 20 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 129309300.0 24155800.0 76552400.0 28601100.0 True False 36646114.62552971 62891026.11336889 22948080.048692524 1.0 1.7161717348762406 0.6262077244255964 25.12715691011157 -6.729471620597754 1.7250839103141937 1.4312528322756242 0.6269179734893384 0.5567736483424728 0.3010762171840014 0.33726790006476876 1.9660478547726772 0.13831774473708214 0.34344112150263245 1.8643540023274066e-07 6.729471620597754 -0.8043348587862857 ILDSAPTGIK(ub)HDGTMCDTCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILDSAPTGIKHDGTMCDTCR 20 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 29795600.0 9208600.0 9440000.0 11147000.0 True False 12613268.273057919 9022909.586094517 8514308.179671273 1.0 0.715350644318535 0.6750279146807596 23.588438810647173 -13.999999999999998 0.27530038008140956 3.2609091614165306 0.6623161356971861 0.9995948298289028 0.0029112089919044425 15.14982374110669 0.16614991106449337 19.231117733820813 0.0163149607371189 1.0000000000000041e-14 13.999999999999998 -2.5985930257193446 ILDSAPTGIK(ub)HDGTMCDTCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILDSAPTGIKHDGTMCDTCR 20 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 16916400.0 7096100.0 1529500.0 8290800.0 True False 5900721.560531703 1521260.2799180187 10024367.947671987 1.0 0.2578091957589236 1.6988376497413835 22.49245995229868 -6.766726662363995 1.5871719398543924 0.5725246601357203 1.7059259600057874 0.7178374847668638 0.31254466744241877 0.27174354487966323 1.3504990433169157 0.15527069218415343 0.3707014819723089 1.7110919087026502e-07 6.766726662363995 1.133401299870067 ILDSAPTGIK(ub)HDGTMCDTCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILDSAPTGIKHDGTMCDTCR 20 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 75997600.0 16668000.0 51618600.0 7711000.0 True False 21577054.57539999 48745979.53360384 6307677.121541433 1.0 2.2591581887723984 0.29233263045702346 24.362994604130883 -6.7337366323822225 1.7093908012257948 1.7545233420848203 0.29259123567956474 0.5767625581373368 0.5291756177796664 0.32918706844830126 1.8860189170670723 0.24514845842729802 0.6058128105061645 1.8461346244705506e-07 6.7337366323822225 -1.4619321064052555 ILDSFAAAPVPTTTLVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILDSFAAAPVPTTTLVLK 18 0 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;P18583-6;P18583-8;P18583-3 P18583-2;P18583-3 SON Protein SON 0 9175700.0 2387600.0 4025200.0 2762900.0 False True 3130166.7215512875 3424655.8501067124 2477021.6116082254 1.0 1.094080972277885 0.7913385554046884 21.5778080705554 -6.82321844774438 1.3578166848121849 1.0505514091638004 0.7842578489801257 0.8916392977506368 0.04164491021712196 0.18933346971613874 0.684991035253479 0.02409558447092231 0.05549663129195232 1.502386084036788e-07 6.82321844774438 -0.26629356018367467 ILDSFAAAPVPTTTLVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILDSFAAAPVPTTTLVLK 18 0 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;P18583-6;P18583-8;P18583-3 P18583-2;P18583-3 SON Protein SON 0 18915700.0 8444800.0 4013700.0 6457200.0 False True 8176724.446449811 5616391.341168993 4765865.608152301 1.0 0.6868754570306611 0.5828575537019052 22.963091592042897 -13.999999999320094 0.15399341072862419 2.524156356079315 0.47350967020392504 0.9995534615973468 0.0037463172774303004 11.974998052794763 0.1237798308666521 5.456043726471233 0.09896380667186672 1.0000000015655412e-14 13.999999999320094 -2.05064668587539 ILDSFAAAPVPTTTLVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILDSFAAAPVPTTTLVLK 18 0 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;P18583-6;P18583-8;P18583-3 P18583-2;P18583-3 SON Protein SON 0 23862500.0 4734500.0 12249000.0 6879000.0 False True 7182582.638313379 10063070.248126188 5519362.63482719 1.0 1.4010378654674565 0.7684370529043091 22.776071255926254 -6.735441328778819 1.7037358733774297 1.2398762465241562 0.7684492352758631 0.5841244166632612 0.16852706215820693 0.3261430535610156 1.8570578694312558 0.07831685685246882 0.1931266947025839 1.8389023644803492e-07 6.735441328778819 -0.4714270112482931 ILDSFAAAPVPTTTLVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILDSFAAAPVPTTTLVLK 18 0 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;P18583-6;P18583-8;P18583-3 P18583-2;P18583-3 SON Protein SON 0 15274300.0 2387600.0 5927400.0 6959300.0 False True 3270360.2424639007 5665507.868709397 5315656.671282524 1.0 1.732380364446023 1.6254040158211103 21.64101813207829 -10.214393934799782 4.727599564248475 0.9998688495245668 1.678892190136311 0.9817180729124176 0.043672911455606644 30744436.433678437 10.350195319776411 43892.77092666019 0.014950399221183502 6.103881099593712e-11 10.214393934799782 0.6790233406117442 ILDSFAAAPVPTTTLVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILDSFAAAPVPTTTLVLK 18 0 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;P18583-6;P18583-8;P18583-3 P18583-2;P18583-3 SON Protein SON 0 17383300.0 8444800.0 4095200.0 4843300.0 False True 7022225.368072336 4073138.344766442 5856011.637110977 1.0 0.5800352639329426 0.8339253342304087 22.743496867477173 -10.336204721861037 5.782820447287918 1.0000424901156837 0.7069802990816747 0.6397683824222826 0.10365018716469426 5.6788828131032776e-05 6.5187223676143685e-06 0.10037338359233976 0.03345295406001133 4.611001655432497e-11 10.336204721861037 -0.293062191034009 ILDSVGIEADDDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILDSVGIEADDDR 13 0 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 66481000.0 13181000.0 23445000.0 29855000.0 False True 17280418.644985575 19947097.387894224 26765890.989381995 1.0 1.1543179478283336 1.5489144990795065 24.042634833664792 -6.954976358521114 0.501244412705021 0.9921819867459121 1.7281058033989443 0.9995361523375076 0.004978068076265566 0.0815469042660288 0.028152815579811332 0.005824417959756662 0.0325520951597372 1.1092351965193886e-07 6.954976358521114 0.7359238166530322 ILDSVGIEADDDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILDSVGIEADDDR 13 0 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 55690000.0 17026000.0 10235000.0 28429000.0 False True 16485518.949561222 14321888.874819892 20982592.04828125 1.0 0.8687557194067635 1.2727892954100617 23.97469596669902 -6.819235000932646 1.3750480021199032 0.9292009252886192 1.2814741141780532 0.8826208336024117 0.057655932424170254 0.19449425104658846 0.7227777358391353 0.03295004650287145 0.0759654157490292 1.5162296989303917e-07 6.819235000932646 0.35227318888943404 ILDSVGIEADDDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILDSVGIEADDDR 13 0 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 49377000.0 13181000.0 18716000.0 17480000.0 False True 18054371.903131478 17889065.23446454 13351584.011900423 1.0 0.990843953500356 0.7395208254010005 24.105844895187683 -6.914612324407538 0.8637277535126949 1.0066929344280933 0.7036203439529874 0.9925489790034595 0.010417948381035559 0.10144659801262494 0.12280513681557494 0.008728816001561742 0.024939999658220045 1.2172721211196335e-07 6.914612324407538 -0.3030725904751058 ILDSVGIEADDDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILDSVGIEADDDR 13 0 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 37815600.0 17026000.0 10824000.0 9965600.0 False True 14157873.37968924 10765688.963604225 12049360.884271722 1.0 0.7604029697743014 0.8510713834718728 23.755101242133296 -10.346964631094089 4.981499387202339 1.0001084661952544 0.8057371766230406 0.8595657557205904 0.03701522489126531 4.4614721567395844e-05 5.84869414404714e-06 0.03585979251595195 0.011946612463309655 4.498164864182809e-11 10.346964631094089 -0.19437128957221383 ILDSVGIEADDDRLNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILDSVGIEADDDRLNK 16 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 205832400.0 32975500.0 87994500.0 84862400.0 False True 43231199.83519622 74866063.5998746 76081652.90562159 1.0 1.731760022513259 1.7598783562717712 25.365569541441566 -11.220719901768913 0.54666499655851 2.1775364189335943e-19 1.7575029013408288 0.9998888378694352 0.003708826910613997 3.4318368108623245 0.2684129269942421 4.1902616401754225 0.005279260455016522 6.0156158955132025e-12 11.220719901768913 1.7575029013408288 ILDSVGIEADDDRLNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILDSVGIEADDDRLNK 16 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 133599610.0 43223500.0 25430110.0 64946000.0 False True 41851393.65184768 35584485.53927173 47934694.261763506 1.0 0.8502580782683379 1.1453547917787739 25.318772329547066 -6.76873692325284 1.579132366957253 0.913975252521058 1.1469424675451028 0.7257830948712024 0.06308874034173377 0.26846594441577626 1.3209911015368487 0.03149348821004559 0.07505954046300813 1.7031899144983863e-07 6.76873692325284 0.23296721502404472 ILDSVGIEADDDRLNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILDSVGIEADDDRLNK 16 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 374794000.0 13919000.0 334389000.0 26486000.0 False True 21116140.61520414 274714670.3568185 21251030.490773797 1.0 13.009700748015344 1.0063879985470703 24.331842842463907 -6.6460439528855 2.022685653339974 8.817267940445323 1.0566928443857204 0.17821062771664775 5.130866545817013 0.5182528694977266 4.059477683416348 2.0605152345234887 5.682208442103871 2.25920711500953e-07 6.6460439528855 -7.760575096059602 ILDSVGIEADDDRLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILDSVGIEADDDRLNK 16 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 136799300.0 32975500.0 50561000.0 53262800.0 False True 45167433.479380295 48327047.83713193 40683223.62179921 1.0 1.0699533737995996 0.900720286450896 25.428779602964457 -6.794498004952323 1.4787484611934936 1.038869817774614 0.898701885640947 0.8154361729720041 0.029829482948724718 0.2287157334771413 0.9879267836296475 0.0158754286252649 0.03704320726307978 1.6050996315337397e-07 6.794498004952323 -0.14016793213366707 ILDSVGIEADDDRLNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILDSVGIEADDDRLNK 16 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 78192500.0 43223500.0 20200000.0 14769000.0 False True 35942255.375719324 20091178.59061395 17857129.615859464 1.0 0.5589849156819047 0.4968282994261621 25.099177604981342 -13.999999999999998 0.27602698594527814 4.516788189665393 0.47737208390074376 0.9995964225842155 0.004499763556877719 15.187417405780327 0.1663767977516565 30.07993624292543 0.025060480091992545 1.0000000000000041e-14 13.999999999999998 -4.039416105764649 ILDSVGIEADDDRLNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILDSVGIEADDDRLNK 16 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 77270000.0 13919000.0 40519000.0 22832000.0 False True 18018419.884508785 38264082.0309364 18676810.27610351 1.0 2.123609188607803 1.0365398517636262 24.102969164556356 -6.638426385297503 2.0497327201495588 1.7356317574970053 1.0410071965979444 0.1487545554008648 0.48094414503974203 0.5373451419657547 4.312658024516564 0.19118622795894383 0.5326978862997324 2.2991833972868645e-07 6.638426385297503 -0.6946245608990609 ILDSVGIEADDDRLNK(ub)VISELNGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILDSVGIEADDDRLNKVISELNGK 24 2 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 50799400.0 31708000.0 1905700.0 17185700.0 True False 30701446.89608172 2666655.9480942125 12684249.610051256 1.0 0.08685766365084718 0.4131482679948249 24.87180331266083 -10.496987879926357 6.153475127246815 1.000602264098814 0.2500029672142339 0.875691094687128 0.13320758141784977 0.0011014249925788418 9.00354298454518e-05 0.129071801705461 0.042992562034991695 3.1842863859613035e-11 10.496987879926357 -0.75059929688458 ILDSVGIEADDDRLNK(ub)VISELNGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILDSVGIEADDDRLNKVISELNGK 24 2 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 399710000.0 25005000.0 239771000.0 134934000.0 True False 37934413.11036564 196981991.71062648 108264235.75632687 1.0 5.192699070828668 2.8539847299428365 25.17700388193082 -9.511818309447305 8.626189530954901 0.9999886609204396 4.023341900392575 0.6902321806645151 0.9547761315725176 0.0 0.0 0.9244580142239837 0.3081526714079945 3.077383993555243e-10 9.511818309447305 3.0233532394721356 ILDSVGIEADDDRLNK(ub)VISELNGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILDSVGIEADDDRLNKVISELNGK 24 2 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 113834700.0 31708000.0 67802000.0 14324700.0 True False 26366606.902571745 67436737.1683568 17319928.540070564 1.0 2.557657017360818 0.6568887913439182 24.652208588095107 -6.688940766345602 1.870580521697879 1.9775373482370646 0.6636074678188072 0.365330938200883 0.6589233366578817 0.418925929960899 2.8413001186287348 0.2819138004087874 0.7349962725383392 2.0467237714277493e-07 6.688940766345602 -1.3139298804182573 ILDSVGIEADDDRLNK(ub)VISELNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILDSVGIEADDDRLNKVISELNGK 24 2 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 373387000.0 25005000.0 264214000.0 84168000.0 True False 32369465.422238808 249510258.6372281 68850287.63661003 1.0 7.70819830919441 2.1270134288133096 24.94813020402327 -6.600918976352144 2.187373843380338 5.508757712437189 2.1453249998791746 0.023135293269066715 2.8988231488043583 0.6381121073416832 5.771499582482084 1.0995628131242412 3.223725248560557 2.506576846023791e-07 6.600918976352144 -3.363432712558015 ILDWHVANTDK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILDWHVANTDKK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 4622500.0 1869100.0 1238500.0 1514900.0 True False 2450408.2003901494 1053720.6276351875 1358152.6799469027 1.0 0.43001840569559635 0.5542556867589082 21.224590669419065 -9.844046287241893 6.589719106176258 1.000000012255644 0.49213704622749904 0.9570458791455554 0.05071965760612174 9.143522619401242e-09 1.5546878655005843e-09 0.04910909804017902 0.016369699102799395 1.4320352643727904e-10 9.844046287241893 -0.5078629660281451 ILDWHVANTDK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILDWHVANTDKK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 8667400.0 2644700.0 1676600.0 4346100.0 True False 2560745.4461355885 2346075.1233534943 3207726.0297947614 1.0 0.9161688159570673 1.2526532204267038 21.28813241661709 -6.840748248641772 1.2789429309718197 0.9554078987014603 1.2638835853484782 0.9257301841006513 0.038975513060201 0.1679254891863771 0.5332394187419378 0.023893436226227475 0.05505651066130542 1.4429515577431312e-07 6.840748248641772 0.30847568664701797 ILDWHVANTDK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILDWHVANTDKK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 23267900.0 3322500.0 4140400.0 15805000.0 True False 5040475.407286132 3401513.2709071497 12681134.822422417 1.0 0.6748397712624842 2.5158608658404567 22.26512838149942 -6.861288067398751 1.179304205879871 0.8229620180797296 2.607190730972539 0.9551818173552168 0.16984575891332582 0.14547507126351575 0.38373272536859554 0.11227578670494937 0.2624601564503986 1.3762962691649864e-07 6.861288067398751 1.7842287128928094 up ILDWHVANTDK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILDWHVANTDKK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 5256100.0 1869100.0 1267100.0 2119900.0 True False 2560156.7805282655 1211115.3322606315 1619223.280710968 1.0 0.4730629551564919 0.6324703600288322 21.287800730941957 -10.871324558494724 11.080925082649548 1.0167761092807281 0.5527666575926793 0.9130070545808144 0.06507780052641379 0.02365117567264548 0.0002746448998844552 0.05525466452688085 0.021003769803884065 1.3448549366488352e-11 10.871324558494724 -0.46400945168804886 ILDWHVANTDK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILDWHVANTDKK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 6795800.0 2644700.0 2805000.0 1346100.0 True False 2199185.2300754203 2789888.908251096 1627563.2863368134 1.0 1.268601148324108 0.7400755807554221 21.068537692051365 -6.768544651160766 1.579900261285778 1.154351485885975 0.7372576776071339 0.7249742633311282 0.11316094123609126 0.26880759855183134 1.3239344311912729 0.056462634034268655 0.13459153509595034 1.703944122536798e-07 6.768544651160766 -0.417093808278841 ILDWHVANTDK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILDWHVANTDKK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 21011200.0 3322500.0 4696700.0 12992000.0 True False 4301041.746266281 4435324.516268884 10627589.309177324 1.0 1.0312209873617648 2.4709337728244782 22.03625470359187 -6.911578697403058 0.8848974706884333 0.9576180730290711 2.6634263848416326 0.9915041809924925 0.06324566796746685 0.10338384081695436 0.1331666673007471 0.05218761357440611 0.14569039409203435 1.2258047575760276e-07 6.911578697403058 1.7058083118125615 up ILDWHVANTDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILDWHVANTDKK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 41187100.0 8916100.0 16752000.0 15519000.0 False True 11689093.44363523 14252666.898784565 13913242.74875964 1.0 1.219313282720416 1.1902756031380235 23.478659709129232 -10.023957233781395 4.369135937882197 0.9999890954309044 1.2047944429463264 0.9851457966307585 0.011854583169361943 1768133.1404505956 2028283.343154016 147.3665297353959 0.004058139199287952 9.463303446308271e-11 10.023957233781395 0.204805347515422 ILDWHVANTDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILDWHVANTDKK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 23118800.0 10106000.0 3025500.0 9987300.0 False True 9785190.561744727 4233597.927774071 7371326.517422334 1.0 0.43265360046490586 0.7533145594773175 23.222168516221945 -10.198315338708786 5.661267988704287 1.0000117776782704 0.5929840799711105 0.6823554990971447 0.13090928833537951 1.9460764552909257e-05 2.755593106695848e-06 0.1267560383849899 0.04225079113222383 6.334096291813075e-11 10.198315338708786 -0.40702769770715996 ILDWHVANTDKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILDWHVANTDKK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 86281200.0 8222600.0 70627000.0 7431600.0 False True 12474285.352581171 58023060.03873038 5962741.002614014 1.0 4.651413559873736 0.47800261370325375 23.572453830650232 -6.67552575632521 1.9175213793319095 3.3195017167003655 0.4943076278055762 0.3038251919680598 1.5490927521556064 0.4485764099733159 3.1847776577136497 0.6491329760555397 1.7220865250342998 2.110932000887491e-07 6.67552575632521 -2.8251940888947895 ILDWHVANTDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILDWHVANTDKK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 44075100.0 8916100.0 14090000.0 21069000.0 False True 12212623.11854265 13467457.210600836 16092936.129675621 1.0 1.1027489409832805 1.3177296943882122 23.541869770652124 -6.959152940115395 0.44721189430090635 0.9928663203101158 1.4360952677446353 0.9997374792265754 0.0021449193566138096 0.08000509732076432 0.022259905163421273 0.0028617950858660004 0.01779009270440074 1.098618884279542e-07 6.959152940115395 0.44322894743451946 ILDWHVANTDKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILDWHVANTDKK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 18846900.0 10106000.0 5106900.0 3634000.0 False True 8403586.771710295 5079388.116059714 4393852.598282429 1.0 0.6044309714464885 0.5228544331896264 23.00257379165622 -13.999999999999998 0.22192092066104055 3.4073341815849005 0.48001409070649936 0.9994998897571317 0.0046600133848273915 13.052604796735817 0.1492215940782216 13.784284179156826 0.04458138242371097 1.0000000000000041e-14 13.999999999999998 -2.927320090878401 ILDWHVANTDKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILDWHVANTDKK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 19940600.0 8222600.0 7728300.0 3989700.0 False True 10644317.791677687 7298213.311278314 3263615.5377790034 1.0 0.6856440641958715 0.3066063604687449 23.343580152742682 -7.176431616582318 0.3227312084297592 1.0579579611452765 3.2616828781413217e-13 0.9999021767751257 0.0028038400438035378 0.08601025444220113 0.016912145471811156 0.008600909517995812 0.03906231994844428 6.661444032314762e-08 7.176431616582318 -1.0579579611449503 down ILEDDLK(ub)AIIKPQYVDQIPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILEDDLKAIIKPQYVDQIPK 20 2 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 41933500.0 5717800.0 5923700.0 30292000.0 True False 8674320.627172517 4866569.452920658 24304772.92254474 1.0 0.5610317697591224 2.801922359937844 23.04831933955802 -6.855857227163668 1.2064511912781013 0.7639859390702485 2.9021801045161464 0.9484097552259432 0.22023113822502724 0.1511280749035723 0.4203614937221713 0.14259466192171813 0.331464538981909 1.3936148738044733e-07 6.855857227163668 2.138194165445898 up ILEDDLK(ub)AIIKPQYVDQIPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILEDDLKAIIKPQYVDQIPK 20 2 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 31484800.0 5717800.0 5712000.0 20055000.0 True False 7401804.81468815 5394122.178748462 16405195.781677296 1.0 0.7287576900223525 2.216377787904216 22.81944566165047 -6.859693586381876 1.1874176172803124 0.8529684857394632 2.2879449555170313 0.9532493398725642 0.13986918749619745 0.14712169871289496 0.3943624525214859 0.0918881672458222 0.2144017857782829 1.3813585293034113e-07 6.859693586381876 1.4349764697775682 up ILEFFGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILEFFGLK 8 0 P07237;H7BZ94;H0Y3Z3;I3L398;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 237593000.0 72015140.0 83872960.0 81704900.0 False True 94412545.93560784 71359441.30223735 73250860.71674283 1.0 0.7558258343219195 0.7758593944357998 26.4924752479134 -10.673257458857476 6.630300959849612 1.0015962704582988 0.7658426143788597 0.9945401045520381 0.008178666668396643 0.00019418571192925335 9.569499258608425e-06 0.007968220671695808 0.0026396533167401524 2.1219861312686543e-11 10.673257458857476 -0.2357536560794391 ILEFFGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILEFFGLK 8 0 P07237;H7BZ94;H0Y3Z3;I3L398;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 186360640.0 94400640.0 32764000.0 59196000.0 False True 91403943.35549796 45846836.062002875 43690791.758065954 1.0 0.5015848811214902 0.477996792634417 26.44575307169073 -13.831653223144789 0.4366124202337806 9.99999999999279 0.4776881289465228 0.9998814201549447 0.0026211640615858146 28.2203824868894 0.22255308626725503 242.4064033212656 0.005495674618606009 1.4734885887367864e-14 13.831653223144789 -9.522311871046266 ILEFFGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILEFFGLK 8 0 P07237;H7BZ94;H0Y3Z3;I3L398;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 60806000.0 0.0 34106000.0 26700000.0 False True 0.0 28019517.828605752 21422733.29697429 0.0 ILEFFGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILEFFGLK 8 0 P07237;H7BZ94;H0Y3Z3;I3L398;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 262314250.0 72015140.0 83029110.0 107270000.0 False True 98641083.39398228 79360609.37965004 81935035.29499757 1.0 0.8045391093554386 0.8306380310903613 26.555685309436292 -9.959912944140395 6.721048591267747 1.0000000186456146 0.817588570268864 0.9848788357447573 0.010654840181237326 2.9866079058773276e-09 4.5745222271818495e-10 0.010316505720700742 0.003438834881535412 1.0966980110928356e-10 9.959912944140395 -0.1824114483767506 ILEFFGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILEFFGLK 8 0 P07237;H7BZ94;H0Y3Z3;I3L398;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 161056640.0 94400640.0 32651000.0 34005000.0 False True 78498314.81743382 32475102.582283944 41115288.278644554 1.0 0.41370445541171663 0.5237728781091386 26.226158347125008 -9.959587229417314 5.9573974903990745 1.0000003366322996 0.4687386667607598 0.9688104467510056 0.044935245400735804 2.009177784392356e-07 3.5042309491797136e-08 0.043508392150531254 0.01450278809116554 1.0975208276121657e-10 9.959587229417314 -0.5312616698715398 ILEFFGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILEFFGLK 8 0 P07237;H7BZ94;H0Y3Z3;I3L398;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 120373000.0 0.0 80988000.0 39385000.0 False True 0.0 76480946.60582632 32217334.124226343 0.0 ILEFFGLKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILEFFGLKK 9 1 P07237;H7BZ94;H0Y3Z3;I3L398;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 16302600.0 6433400.0 1110700.0 8758500.0 False True 8434249.701134225 944987.8894746898 7852254.437464485 1.0 0.1120417254598959 0.9309962018801181 23.007828303444825 -8.970615109311655 11.602072048766003 0.9999537938428149 0.521518864859592 0.3127827124283865 0.3343367660316646 0.0 0.0 0.3237201812349985 0.10790672707833282 1.070002742182851e-09 8.970615109311655 -0.47843492898322293 ILEFFGLKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILEFFGLKK 9 1 P07237;H7BZ94;H0Y3Z3;I3L398;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 15144270.0 6433400.0 7813600.0 897270.0 False True 8812001.836097874 7468369.315880096 685353.3058557147 1.0 0.847522442095545 0.07777498445905937 23.071038364967716 -7.101995172038185 0.7841449829449332 0.9989285010649575 8.016479448315966e-23 0.995948018052613 0.025693182972031346 0.07947098052089531 0.08427703849424631 0.023282024722093522 0.05653808484678871 7.906874178592441e-08 7.101995172038185 -0.9989285010649575 down ILELDQFK(ub)GQQGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILELDQFKGQQGQK 14 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 14448300.0 3402300.0 5576400.0 5469600.0 True False 4460448.247920064 4744422.8566369545 4903658.260107982 1.0 1.063665038339882 1.0993644556675641 22.088757268832158 -13.999999500799737 0.06790792597484246 0.6249647709808003 1.2346976755501837 0.9999313165907021 0.0003405477923315701 12.382013231675044 0.06961862229389548 0.7454681397880497 0.12507775091342144 1.0000011494517454e-14 13.999999500799737 0.6097329045693834 ILELDQFK(ub)GQQGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILELDQFKGQQGQK 14 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 21666450.0 3576800.0 6514700.0 11574950.0 True False 3463256.441841329 9116053.683711685 8543123.353943266 1.0 2.632220234567701 2.4667891325428664 21.72369778725927 -10.166209353179006 4.541286565527668 0.9997476325678218 2.5495046835453032 0.9915235725257996 0.0675369646855493 3935809.9897025586 8810817.477319274 6141.065577809694 0.023119699114933032 6.820098496464186e-11 10.166209353179006 1.5497570509774814 ILELDQFK(ub)GQQGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILELDQFKGQQGQK 14 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 93060100.0 6964100.0 13372000.0 72724000.0 True False 10565048.843907109 10985662.12408713 58350069.52393852 1.0 1.039811768633951 5.522934194250238 23.332796101309253 -6.908844436092903 0.9035666929116402 0.8560698753422961 6.08820991373288 0.9904781717585702 0.2071435054866119 0.10518716384078886 0.14294838674865576 0.1686281035996515 0.4618468280788042 1.2335466094288748e-07 6.908844436092903 5.232140038390583 up ILELDQFK(ub)GQQGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILELDQFKGQQGQK 14 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 19294000.0 3576800.0 7108000.0 8609200.0 True False 2974267.6791068004 7069707.793172466 10409343.91555671 1.0 2.3769574752248133 3.4998006361965146 21.504103062693545 -7.241284178992837 0.17633058486249775 7.880319440134751e-12 5.606748985136823 0.9999915964534317 0.0029635134932677995 0.10068655854107929 0.009356240955400224 0.08420632204161188 0.1943078592719489 5.737409140999111e-08 7.241284178992837 5.606748985128943 ILELDQFK(ub)GQQGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILELDQFKGQQGQK 14 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 85370100.0 6964100.0 12020000.0 66386000.0 True False 9015164.732933942 11351076.433570812 54304429.177882224 1.0 1.2591091532807364 6.023675749318127 23.103922423401702 -6.918131272908401 0.8384821552286029 0.8876273174115427 6.75989360593178 0.9936456599218564 0.18410250550792703 0.09928358153017383 0.1114078759592968 0.15707332013840655 0.46241449679118146 1.2074488079621762e-07 6.918131272908401 5.872266288520238 up ILELSGSSSEDSEK(ub)VIAGLYQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILELSGSSSEDSEKVIAGLYQR 22 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 15188600.0 4051600.0 5767100.0 5369900.0 True False 3922984.17573371 8069933.105029189 3963362.0964531144 1.0 2.057090404531107 1.0102926544973514 21.903520085305956 -6.643970929145024 2.0307632061826206 1.689211755738453 1.0147272593273584 0.1697707300396526 0.4518569920516254 0.5234180024572879 4.130490779663505 0.18092214911415502 0.500191277230935 2.2700167974489675e-07 6.643970929145024 -0.6744844964110945 ILELSGSSSEDSEK(ub)VIAGLYQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILELSGSSSEDSEKVIAGLYQR 22 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 82845200.0 9852200.0 17422000.0 55571000.0 True False 14946507.692299306 14312907.98129269 44587367.49236547 1.0 0.9576088458889257 2.983129464773744 23.833305096891227 -6.9021209658545954 0.9477606031245909 0.9206167961599148 3.205143559684568 0.9875923322172447 0.10526398596547251 0.10986091086291888 0.16874506679988768 0.08295590976571553 0.21822736920953575 1.2527921809055477e-07 6.9021209658545954 2.2845267635246533 up ILELSGSSSEDSEK(ub)VIAGLYQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILELSGSSSEDSEKVIAGLYQR 22 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 12279800.0 4051600.0 3653200.0 4575000.0 True False 3369084.916313218 3633519.4864965784 5531611.347590024 1.0 1.0784885441453136 1.6418735309418242 21.683925360740233 -6.932170816213007 0.7287495216548594 0.9920851821354764 1.7641997189871397 0.9969480500623908 0.015793481131882812 0.09152597459926509 0.07227130909528474 0.014579161465935762 0.05038180945925559 1.1690394952947067e-07 6.932170816213007 0.7721145368516633 ILENVEVK(ub)GEKPAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILENVEVKGEKPAK 14 2 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 8232400.0 2789300.0 2772100.0 2671000.0 True False 4231572.025144687 2277397.0964838406 2143075.679259113 1.0 0.5381917365345971 0.5064490611348714 22.01276229213914 -13.999999999999998 0.38028829960931904 7.864239539215407 0.5036743342070102 0.9998079835093769 0.003125481551496958 24.072103140366792 0.20114285447595076 135.29209755771515 0.00859637428310767 1.0000000000000041e-14 13.999999999999998 -7.360565205008397 ILENVEVK(ub)GEKPAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILENVEVKGEKPAK 14 2 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 3011560.0 1059600.0 1432400.0 519560.0 True False 881104.348239088 1424683.3768908621 628197.5938259825 1.0 1.6169292317511907 0.7129661714659032 19.748953360520527 -6.722946820517682 1.748656371887259 1.3741298735856688 0.714125344428776 0.5265129435289402 0.2595143741771711 0.3495716551376876 2.0905415311083697 0.11776622929894814 0.2946237651062335 1.892575350844612e-07 6.722946820517682 -0.6600045291568929 ILENVEVK(ub)GEKPAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILENVEVKGEKPAK 14 2 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 8966700.0 2789300.0 2737000.0 3440400.0 True False 3610803.835322965 2584683.543983634 2814282.501485044 1.0 0.7158194302051996 0.7794060906754641 21.78388861423159 -10.096182123920743 5.037257897099721 1.0000070681126467 0.7476127604395131 0.9545576588592651 0.025959145436136023 36125956.06175403 1.5543563698527154 2961.6354666070897 0.008886505955148356 8.01341945503461e-11 10.096182123920743 -0.25239430767313364 ILESLK(ub)NMTVEQLLTGSPTSPTVEPEKPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILESLKNMTVEQLLTGSPTSPTVEPEKPTR 30 2 Q9C0C9;K7ES11 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 62310400.0 30487000.0 24456000.0 7367400.0 True False 29519206.872740086 34221408.336355194 5437656.92273761 1.0 1.1592929472626659 0.18420741946691963 24.815150623545605 -6.864996228265836 1.160308560986533 1.0878595888009603 0.13229585928398602 0.9594250240506611 0.08603053129790196 0.14173892887080644 0.35982310338493045 0.05770243399632078 0.13553912285051012 1.364594987688581e-07 6.864996228265836 -0.9555637295169743 down ILESSQTLLSVLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILESSQTLLSVLKR 14 1 O43805 O43805 SSNA1 Sjoegren syndrome nuclear autoantigen 1 1 5142930.0 2085900.0 2211500.0 845530.0 True False 2019684.2462639343 3094563.482820148 624060.327643718 1.0 1.5322016243601218 0.3089890554912835 20.945698331629874 -6.788432194313365 1.502486630478854 1.2980436994696096 0.2965125751649143 0.796274136529818 0.22602997574726283 0.2376746039895024 1.059966709933341 0.1184211219669633 0.2775852460567791 1.6276754221046873e-07 6.788432194313365 -1.0015311243046954 down ILEVHVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILEVHVDK 8 0 O60884 O60884 DNAJA2 DnaJ homolog subfamily A member 2 0 7287300.0 2917600.0 1782200.0 2587500.0 False True 3996315.565175357 1703456.51105272 1976385.7912352593 1.0 0.426256756572719 0.4945519839468774 21.9302390779646 -10.377000818950842 5.863438504090352 1.0001199916533394 0.4604043702608288 0.9881281495577475 0.02788140982234352 4.37436722712788e-05 4.647842181451548e-06 0.02700199031052656 0.008998686325892985 4.197581924505584e-11 10.377000818950842 -0.5397156213925106 ILFEITAGALGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILFEITAGALGK 12 0 Q9Y3E7-2;Q9Y3E7-4;Q9Y3E7;Q9Y3E7-3 Q9Y3E7-2 CHMP3 Charged multivesicular body protein 3 0 1831130.0 819330.0 0.0 1011800.0 False True 793320.8176285672 0.0 746779.2266506377 1.0 0.0 0.9413332034862594 19.59754488185771 -11.796072411898717 16.784067920091147 0.8501690616073397 0.5235999415688488 0.0 0.4745576862006179 0.0 0.0 0.0 0.1343441413773927 1.5992913492458596e-12 11.796072411898717 -0.3265691200384909 ILFFNTPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILFFNTPK 8 0 R4GMR5;P48556;K7EJR3;K7EJC1 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 11360200.0 2125700.0 3390600.0 5843900.0 False True 2786813.28530808 2884735.696455287 5239229.286647114 1.0 1.0351377724741906 1.8800072879902041 21.41018491536698 -6.915643608937998 0.8564091360947038 0.9782738436708173 2.003477027831369 0.9928826640558956 0.03432027239418757 0.10080397193294546 0.1193973359152518 0.028907268587057673 0.08329194737162844 1.2143849912003885e-07 6.915643608937998 1.0252031841605516 ILFFNTPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILFFNTPK 8 0 R4GMR5;P48556;K7EJR3;K7EJC1 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 7720700.0 3040400.0 1014900.0 3665400.0 False True 2943884.1662308215 1420154.8626335831 2705321.7803570335 1.0 0.4824085400248159 0.9189633924424311 21.489289475742186 -10.118419834746511 7.545524546021144 1.0000000667025297 0.7006859662336246 0.38528879860265897 0.1782227721931954 2.000005429631009e-07 2.3514123493952062e-08 0.17256349572550114 0.057521152384930316 7.613426602355734e-11 10.118419834746511 -0.29931410046890516 ILFFNTPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILFFNTPK 8 0 R4GMR5;P48556;K7EJR3;K7EJC1 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 6430000.0 2125700.0 4304300.0 0.0 False True 2911628.734882524 4114121.793583332 0.0 1.0 1.4129966998520247 0.0 21.47339497688987 -6.854919962148355 1.3949538317208678 1.2189045996335823 3.9332399268062794e-21 0.9019037492673477 0.18579653770685386 0.17003596310392066 0.6650447614033909 0.10724095689492953 0.2251730555468032 1.3966257270312709e-07 6.854919962148355 -1.2189045996335823 down ILFFNTPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILFFNTPK 8 0 R4GMR5;P48556;K7EJR3;K7EJC1 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 6299400.0 3040400.0 2088700.0 1170300.0 False True 2528227.312557688 2077447.7585255087 1415004.3191441766 1.0 0.8217013352426183 0.5596823956911864 21.269694751176463 -6.965595804402001 0.34767501005651147 1.0260080198209112 0.3465657099934677 0.9999249047501475 0.0015670931750547637 0.07775936651528748 0.014150296073119982 0.0036184461282932445 0.022556415707980428 1.0824409047186396e-07 6.965595804402001 -0.6794423098274435 ILFIFIDSDHTDNQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILFIFIDSDHTDNQR 15 0 P07237;H7BZ94;H0Y3Z3;I3L398;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 52674100.0 22069100.0 21164000.0 9441000.0 False True 28932803.81746839 18006413.696625847 8464135.884466773 1.0 0.6223528770396717 0.29254461260876796 24.786202802810955 -7.619778382291742 0.2706103911722273 1.1210087051072721 4.830159420584964e-13 0.999736941916956 0.004687914187026859 0.12831008935382535 0.03278986720063323 0.03237639136268356 0.073673484274392 2.4000573405614922e-08 7.619778382291742 -1.1210087051067892 down ILFIFIDSDHTDNQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILFIFIDSDHTDNQR 15 0 P07237;H7BZ94;H0Y3Z3;I3L398;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 206895900.0 95647500.0 62485700.0 48762700.0 False True 92611222.4672945 87436565.86862066 35990286.02035685 1.0 0.944124950942082 0.3886168982713381 26.46468369157284 -6.926291125656373 0.7766331534257788 1.0097096372907233 0.28464688646809055 0.9957577210035414 0.017975551721210355 0.09460992106867709 0.08745394676067386 0.016028704666010973 0.051327072590777616 1.1849741444091017e-07 6.926291125656373 -0.7250627508226327 down ILFIFIDSDHTDNQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILFIFIDSDHTDNQR 15 0 P07237;H7BZ94;H0Y3Z3;I3L398;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 999520000.0 247622000.0 407545000.0 344353000.0 False True 375660677.5930793 334815410.586381 276291478.61471844 1.0 0.891270847754413 0.735481499913603 28.48485486839643 -6.9660083396783605 0.3403179506191978 1.0168354845122467 0.6047371856685746 0.9999324298242016 0.0008923348966887732 0.07762058908555901 0.013663562473268635 0.0021970482971831948 0.013481078973379494 1.0814131849168186e-07 6.9660083396783605 -0.4120982988436721 ILFIFIDSDHTDNQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILFIFIDSDHTDNQR 15 0 P07237;H7BZ94;H0Y3Z3;I3L398;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 144575800.0 22069100.0 49786000.0 72720700.0 False True 30228642.66500255 47586289.899714224 55545568.38982884 1.0 1.5742119296281742 1.8375144727929567 24.849412864333846 -10.59473936101738 0.16071452400231306 4.770015888547193e-16 2.1642103954992815 0.9996154694586761 0.006857008781125527 2.4626434191238813 0.08585837684435497 1.1802349345422556 0.22016413080398908 2.542498111325029e-11 10.59473936101738 2.164210395499281 ILFIFIDSDHTDNQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILFIFIDSDHTDNQR 15 0 P07237;H7BZ94;H0Y3Z3;I3L398;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 185719200.0 95647500.0 38623000.0 51448700.0 False True 79535134.1526974 38414930.23293472 62206385.29808845 1.0 0.48299321604440765 0.7821246039349108 26.245088967007117 -10.226909743303253 5.718359360929545 1.0000139437572846 0.6325589099896548 0.6679753992849022 0.12211987773040825 2.170982658395724e-05 2.935070946672615e-06 0.11824654690260977 0.03941402105755908 5.930485613346055e-11 10.226909743303253 -0.3674550337676298 ILFIFIDSDHTDNQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILFIFIDSDHTDNQR 15 0 P07237;H7BZ94;H0Y3Z3;I3L398;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 936567000.0 247622000.0 348347000.0 340598000.0 False True 320551560.35935247 328961183.22837704 278612658.8306017 1.0 1.026234852388792 0.8691664408629445 28.25598119048888 -6.863973467697667 1.1655840466191214 1.014412507455205 0.8609657475082513 0.9582847688605494 0.01403132650393195 0.14275950797314282 0.3663278448709034 0.009373182393537197 0.021985893285051752 1.3678123866465757e-07 6.863973467697667 -0.15344675994695378 ILFIGGITAPTVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILFIGGITAPTVR 13 0 P48651;P48651-3;P48651-2 P48651 PTDSS1 Phosphatidylserine synthase 1 0 6777600.0 1374000.0 3890000.0 1513600.0 False True 1801327.305834929 3309627.163101234 1356987.1914764224 1.0 1.8373269268614103 0.7533262761746946 20.78062891581106 -6.700404025386801 1.8291512860741268 1.5197244138631514 0.75649386961266 0.41965682488145006 0.35341780981443816 0.3946638553219575 2.5673884354497987 0.15411662235243292 0.3961905667564796 1.9934069799305388e-07 6.700404025386801 -0.7632305442504914 ILFIGGITAPTVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILFIGGITAPTVR 13 0 P48651;P48651-3;P48651-2 P48651 PTDSS1 Phosphatidylserine synthase 1 0 3725890.0 1686800.0 889190.0 1149900.0 False True 1633253.4573076402 1244248.2040645918 848706.693739442 1.0 0.7618218706334107 0.5196417555046873 20.639317262995764 -6.970917645439504 0.2352408408887925 1.0922577145387986 0.18224207863676492 0.9999886804916672 0.0006597688422250716 0.0760060645107532 0.007956958498585557 0.005989343045276795 0.023815207908128345 1.069257621593352e-07 6.970917645439504 -0.9100156359020337 ILFIGGITAPTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILFIGGITAPTVR 13 0 P48651;P48651-3;P48651-2 P48651 PTDSS1 Phosphatidylserine synthase 1 0 5961900.0 1374000.0 1793400.0 2794500.0 False True 1882004.9309538482 1714161.6580192691 2134496.6545340787 1.0 0.9108167730200836 1.1341610319013677 20.843838977333952 -6.798334215161235 1.4626130160975743 0.9506891528402167 1.137122003140179 0.8272740150166592 0.038149936926829456 0.22314353984221605 0.942569770808094 0.02052102336506081 0.047775521564235104 1.5909839000858873e-07 6.798334215161235 0.18643285029996226 ILFLDVLFPLVVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILFLDVLFPLVVDK 14 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 119714000.0 43834000.0 53528000.0 22352000.0 False True 66499382.69465168 43975510.18382712 17934117.40277036 1.0 0.6612920060589362 0.2696884794422722 25.986837612532156 -7.324039809937518 0.3382947507026852 1.0562710684084218 2.9463417096885516e-16 0.9997344897180798 0.004862417805514982 0.10647682715716944 0.026285438427925245 0.013205762461702065 0.05201095891759876 4.741985154964997e-08 7.324039809937518 -1.0562710684084216 down ILFQNQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILFQNQK 7 0 Q9NZR2 Q9NZR2 LRP1B Low-density lipoprotein receptor-related protein 1B 0 243545000.0 69776000.0 53599000.0 120170000.0 False True 91477011.71174519 45602238.1272656 107735961.15203607 1.0 0.4985103609523627 1.177738091090303 26.446905902074565 -6.708926430445741 1.7992599665706979 0.6913542982286696 1.1760768524500826 0.4599101117348342 0.21136086407281304 0.3772309455648107 2.379946759780603 0.09351091850335061 0.2378511685469913 1.9546705492326652e-07 6.708926430445741 0.4847225542214131 ILFQNQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILFQNQK 7 0 Q9NZR2 Q9NZR2 LRP1B Low-density lipoprotein receptor-related protein 1B 0 59014000.0 19327000.0 12772000.0 26915000.0 False True 18713474.96406494 17871926.205100138 19865154.0673077 1.0 0.9550297974811834 1.0615427709420244 24.157574146249665 -6.792032260540512 1.488490664394158 0.9749323412530564 1.0627352524257572 0.8077533054339812 0.019142628577078116 0.23233767104091016 1.0169298566292655 0.010122118541953641 0.02366080956137083 1.6142386424653374e-07 6.792032260540512 0.08780291117270078 ILFQNQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILFQNQK 7 0 Q9NZR2 Q9NZR2 LRP1B Low-density lipoprotein receptor-related protein 1B 0 180574000.0 69776000.0 33812000.0 76986000.0 False True 95574072.82549897 32318074.0386682 58803492.3764397 1.0 0.33814687480856004 0.6152661557471164 26.510115963597457 -10.402629252942297 5.987261655806651 1.000138717214506 0.47670651527796976 0.8262199977068992 0.1131334726977415 0.00020953892927093453 2.0906487486793574e-05 0.1095696468148162 0.0365136713047469 3.957042794246598e-11 10.402629252942297 -0.5234322019365363 ILFQNQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILFQNQK 7 0 Q9NZR2 Q9NZR2 LRP1B Low-density lipoprotein receptor-related protein 1B 0 81172000.0 19327000.0 11871000.0 49974000.0 False True 16071256.831272988 11807048.566790994 60423332.34633089 1.0 0.7346686504204021 3.7597141891699093 23.93797942168394 -6.8855320460515115 1.048495440621005 0.8196271872851009 3.998174303462002 0.977879343951977 0.2034296615462143 0.12284130498439552 0.24364656129346196 0.14863762977000958 0.36505624235150624 1.3015712707050247e-07 6.8855320460515115 3.178547116176901 up ILFRPVASQLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILFRPVASQLPR 12 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2;D6RBK0 P35232 PHB Prohibitin 0 26958600.0 5567000.0 12813000.0 8578600.0 False True 7298390.91090468 10901350.344682807 7690968.763741842 1.0 1.4936649019984485 1.053789644543512 22.79914699485879 -10.28764218482533 3.8453514491686054 0.9995041151932039 1.2737272733179805 0.3405069760573852 0.17957832206073196 60021285.39263834 216.9856453924142 265157.56101819314 0.06479974533551654 5.156533163234086e-11 10.28764218482533 0.2742231581247766 ILFRPVASQLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILFRPVASQLPR 12 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2;D6RBK0 P35232 PHB Prohibitin 0 31740000.0 18953000.0 5661100.0 7125900.0 False True 18351347.38934769 7921606.752246505 5259413.017582307 1.0 0.4316634950109831 0.28659546931334373 24.129382656466237 -13.999999999999904 0.19173487129807185 4.065107815180415 0.18431954362691627 0.9994885473608025 0.0069623378761968745 12.379500833363252 0.13886054624881028 14.184595719056132 0.09840612314334249 1.0000000000002209e-14 13.999999999999904 -3.8807882715534987 ILFRPVASQLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILFRPVASQLPR 12 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2;D6RBK0 P35232 PHB Prohibitin 0 62886000.0 10697000.0 42913000.0 9276000.0 False True 16228131.055452155 35254839.86920067 7442594.534184764 1.0 2.172452252741459 0.45862302373287034 23.9519935228597 -6.722555414772142 1.7501423593286913 1.7113497774408242 0.4609059378887591 0.5245494548723946 0.49322331060934305 0.35037075878794666 2.098695578170159 0.22365190973137675 0.5597648189129116 1.8942817938290393e-07 6.722555414772142 -1.250443839552065 ILFRPVASQLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILFRPVASQLPR 12 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2;D6RBK0 P35232 PHB Prohibitin 0 37255000.0 5567000.0 14461000.0 17227000.0 False True 7625270.342518233 13822065.203867888 13158337.401201848 1.0 1.8126655951850716 1.7256224120778292 22.862357056381683 -10.153745579919999 4.543518694437143 0.9998912471783463 1.7691440036442854 0.990485985192301 0.035535230757789915 24867217.99272114 6.1556162901144 28593.710774576615 0.012164654661439893 7.01866348076639e-11 10.153745579919999 0.769252756465939 ILFRPVASQLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILFRPVASQLPR 12 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2;D6RBK0 P35232 PHB Prohibitin 0 32247900.0 18953000.0 6784000.0 6510900.0 False True 15760259.260263724 6747453.245481429 7872299.08699975 1.0 0.42813085330986617 0.4995031462996389 23.909787931900514 -10.481730410743646 6.14809155216758 1.0003490954247702 0.4638169998053558 0.9868852160086824 0.029137616599560778 0.00013951222540922953 1.176051894483059e-05 0.028230050749654116 0.009404125319856287 3.2981438165033404e-11 10.481730410743646 -0.5365320956194144 ILFRPVASQLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILFRPVASQLPR 12 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2;D6RBK0 P35232 PHB Prohibitin 0 45387000.0 10697000.0 13682000.0 21008000.0 False True 13847477.36939366 12920584.672555396 17184759.56028305 1.0 0.9330641479229332 1.2410028990742825 23.723119844952148 -6.849779041900546 1.2361598863806853 0.9642874520401326 1.2532605069945892 0.9399834755316285 0.03239675103026024 0.1576996997728245 0.46383771342251096 0.020508638990512654 0.04745147052719549 1.413256391016177e-07 6.849779041900546 0.2889730549544567 ILFSSLILISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILFSSLILISK 11 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 17068100.0 5202100.0 6495800.0 5370200.0 False True 7891966.024452435 5336573.738082946 4308777.616157722 1.0 0.6762033340675984 0.5459701173075787 22.911953314480996 -13.999999999999657 0.12552008315153618 2.5391250650099884 0.352768963110706 0.9996663424981053 0.003486833104651806 11.945972848992929 0.10970761164359381 4.556252763670131 0.17158623210537527 1.0000000000007893e-14 13.999999999999657 -2.1863561018992823 ILFSSLILISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILFSSLILISK 11 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 8890300.0 5202100.0 2572400.0 1115800.0 False True 6734220.998721398 2429243.678678663 912735.8490748189 1.0 0.360731208426319 0.13553696103055077 22.683079636573446 -10.49076708597818 0.2300999786418908 1.7629132844513975 1.6395456343098314e-11 0.999217878740884 0.010240250678581222 2.1821862294456804 0.11621502969418941 1.071310338481312 0.11292208797092271 3.230226041545453e-11 10.49076708597818 -1.762913284435002 ILFSTWNLDHIIEK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILFSTWNLDHIIEKK 15 1 B4DZS0;O76075 B4DZS0 DFFB DNA fragmentation factor subunit beta 1 25045600.0 7420800.0 7862500.0 9762300.0 True False 7185230.76594055 11002037.252395838 7205260.767277641 1.0 1.5312016566743722 1.0027876629143266 22.776603061362632 -10.732040799265567 2.845443430137367 0.9538722860154158 1.266994659570943 0.25395652131322644 0.2157241117998187 57669492.224867195 52853714.71854349 18924460.632324275 0.07890684934060772 1.8533575038253153e-11 10.732040799265567 0.3131223735555271 ILFSTWNLDHIIEK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILFSTWNLDHIIEKK 15 1 B4DZS0;O76075 B4DZS0 DFFB DNA fragmentation factor subunit beta 1 17018000.0 3802600.0 5026700.0 8188700.0 True False 5768822.2072975915 4129646.11121364 6570199.855765288 1.0 0.715856021007133 1.1389152966881089 22.459845370146844 -6.725756132994682 1.738866428182452 0.8281995891828512 1.1384677995399821 0.5394305051241393 0.11949222488130139 0.3442423552455472 2.037151357174532 0.0545036478349926 0.13589337881649521 1.880372395636617e-07 6.725756132994682 0.3102682103571309 ILFSTWNLDHIIEK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILFSTWNLDHIIEKK 15 1 B4DZS0;O76075 B4DZS0 DFFB DNA fragmentation factor subunit beta 1 25787800.0 7420800.0 11268900.0 7098100.0 True False 6170723.997180655 11208192.198998492 8582279.89209371 1.0 1.8163496218789577 1.390805989056531 22.55700833679691 -10.140990663641054 4.368672198769583 0.9999192313011711 1.6035778050447829 0.7284350238143842 0.1737274613696944 25865902.37431435 30021266.660552535 21417.612785194 0.059471531650189514 7.227853417016341e-11 10.140990663641054 0.6036585737436118 ILFSTWNLDHIIEK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILFSTWNLDHIIEKK 15 1 B4DZS0;O76075 B4DZS0 DFFB DNA fragmentation factor subunit beta 1 8354300.0 3802600.0 4551700.0 0.0 True False 4922540.660452118 4298393.893734135 0.0 1.0 0.8732063765907709 0.0 22.230971692239294 -7.148367526218409 0.9394438764994694 0.9943578044806183 7.759011379430314e-21 0.989685475945129 0.04514798073930929 0.08771605229678521 0.14659039511050564 0.037746715151085096 0.06631471441355478 7.106118964249367e-08 7.148367526218409 -0.9943578044806183 down ILGADTSVDLEETGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILGADTSVDLEETGR 15 0 P25705;P25705-2;P25705-3;K7EK77;K7ERX7;K7EJP1;K7EQH4;K7ESA0 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 45402400.0 8204400.0 17935000.0 19263000.0 False True 10756047.851522632 15259167.910082456 17269849.54374363 1.0 1.4186593552502986 1.6055943393092007 23.35864474281321 -11.439621553027111 0.1433750891952337 9.412875000139396e-19 1.8661641348251865 0.999659979205348 0.00466880601129168 4.1381818332938645 0.09080752405802081 1.4946356649122676 0.19100976497277217 3.633945811871104e-12 11.439621553027111 1.8661641348251865 ILGADTSVDLEETGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILGADTSVDLEETGR 15 0 P25705;P25705-2;P25705-3;K7EK77;K7ERX7;K7EJP1;K7EQH4;K7ESA0 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 54140200.0 17173000.0 7098200.0 29869000.0 False True 16627852.515024938 9932548.276624005 22045412.84920727 1.0 0.597344020681501 1.3258123879368682 23.98709852099191 -6.756686078564726 1.6252504544845698 0.7651503855870067 1.3280187973829194 0.6771784264430816 0.16928570479460622 0.2885183746430055 1.5012880892569804 0.08221924012740858 0.19821369241132658 1.7511119889805836e-07 6.756686078564726 0.5628684117959127 ILGADTSVDLEETGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILGADTSVDLEETGR 15 0 P25705;P25705-2;P25705-3;K7EK77;K7ERX7;K7EJP1;K7EQH4;K7ESA0 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 145439000.0 7592000.0 122510000.0 15337000.0 False True 11517619.04954592 100647133.32500102 12305635.227554105 1.0 8.73853640166793 1.0684183227990383 23.457339174356992 -6.644220872682048 2.030548066572654 6.044529839325634 1.1012951907266706 0.17060502623380547 3.3076687269126115 0.5227114318367337 4.1245895987998535 1.3246126418867108 3.6600030631515974 2.268710741730223e-07 6.644220872682048 -4.943234648598963 ILGADTSVDLEETGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILGADTSVDLEETGR 15 0 P25705;P25705-2;P25705-3;K7EK77;K7ERX7;K7EJP1;K7EQH4;K7ESA0 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 33692900.0 17173000.0 9067100.0 7452800.0 False True 14280110.392893404 9018253.73262157 9011146.022146214 1.0 0.6315254913652184 0.6310277563841995 23.767503796426187 ILGADTSVDLEETGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILGADTSVDLEETGR 15 0 P25705;P25705-2;P25705-3;K7EK77;K7ERX7;K7EJP1;K7EQH4;K7ESA0 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 49362000.0 7592000.0 23575000.0 18195000.0 False True 9827993.660693336 22263030.525909502 14883696.69646561 1.0 2.265267082431035 1.5144186301210545 23.22846549644944 -10.05947639887476 4.829670337788994 0.9999773403471889 1.8898428562886438 0.6518915535455745 0.3065325970985201 8.423648003832712e-05 1.640431585021603e-05 0.2968073955079147 0.09893297029617472 8.72014288394414e-11 10.05947639887476 0.8898655159414549 ILGENAK(ub)PNYGCQVTIQSEQEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILGENAKPNYGCQVTIQSEQEK 22 1 Q8N3C0;Q8N3C0-4 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 1 25608500.0 6046300.0 9807100.0 9755100.0 True False 9172679.143739391 8056946.381777967 7827000.209187778 1.0 0.8783634808895564 0.8532948865359499 23.128911745114223 -13.999999999999872 0.22201116326010115 1.740545711350063 0.8401413434803712 0.9994999798396909 0.0014326967097252423 13.055246825310338 0.14925251347291696 4.2431184367699695 0.013691971866706445 1.0000000000002946e-14 13.999999999999872 -0.9004043678696919 ILGENAK(ub)PNYGCQVTIQSEQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILGENAKPNYGCQVTIQSEQEK 22 1 Q8N3C0;Q8N3C0-4 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 1 22670700.0 6046300.0 9883800.0 6740600.0 True False 7827054.540391213 9333757.841441538 5513879.964396602 1.0 1.1924993997774054 0.7044642318438483 22.900038067206673 -6.799661326466401 1.4570324889680089 1.1062520811854293 0.6977614618068152 0.8312806068981076 0.08244429607491076 0.22121682108537608 0.9271613323534122 0.04451293536263778 0.10355422508159996 1.5861296132413173e-07 6.799661326466401 -0.4084906193786141 ILGGSVLHLVLALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILGGSVLHLVLALR 14 0 Q15843 Q15843 NEDD8 NEDD8 0 246521000.0 141500000.0 48096000.0 56925000.0 False True 137008159.95318422 67300983.61732657 42014634.786605574 1.0 0.49121879777323746 0.3066579012590345 27.029686579097962 -13.999999999999998 0.1410732616992173 3.4327640381657423 0.0811806770460428 0.9995986895851411 0.005873397804873203 11.935241846187553 0.1177553145260293 7.988281119288418 0.20172254379336577 1.0000000000000041e-14 13.999999999999998 -3.3515833611196997 ILGGSVLHLVLALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILGGSVLHLVLALR 14 0 Q15843 Q15843 NEDD8 NEDD8 0 2609664000.0 737738000.0 1019005000.0 852921000.0 False True 1119202481.8722222 837155596.2275953 684340790.5014455 1.0 0.747992976951933 0.6114539608209838 30.059823920833853 -13.999999999990766 0.07495565830496444 2.4045355378376656 0.1627422648232038 0.9999066389273195 0.0015550594909334355 12.309264034597536 0.07553278418767004 2.938840393229022 0.41024250965304987 1.0000000000212609e-14 13.999999999990766 -2.2417932730144616 ILGGSVLHLVLALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILGGSVLHLVLALR 14 0 Q15843 Q15843 NEDD8 NEDD8 0 359095000.0 141500000.0 97585000.0 120010000.0 False True 117663519.51286437 97059290.23589405 145103536.13645425 1.0 0.8248885520144787 1.2332075118710843 26.81009185453224 -6.7901448858607685 1.4955915166738114 0.9021507784858003 1.2375782635807295 0.8018625220653299 0.07445049961288379 0.23512341699590722 1.038950409995483 0.039181168911207334 0.09172945827843361 1.6212691322523674e-07 6.7901448858607685 0.33542748509492926 ILGGSVLHLVLALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILGGSVLHLVLALR 14 0 Q15843 Q15843 NEDD8 NEDD8 0 1902548000.0 737738000.0 516596000.0 648214000.0 False True 955016383.9900663 487846978.4756196 530245703.23730487 1.0 0.5108257687029315 0.5552215774790522 29.830950242926303 -10.025489228519247 7.522200261164084 1.000000021818698 0.5330236739374429 0.993266801128941 0.018124513036611948 6.625219817927683e-09 8.517131282348384e-10 0.017548985333227782 0.005849661429076435 9.4299799964295e-11 10.025489228519247 -0.4669763478812551 ILGIPTQLYSHHFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILGIPTQLYSHHFQR 15 0 Q86UA1 Q86UA1 PRPF39 Pre-mRNA-processing factor 39 0 7911400.0 2412400.0 1442300.0 4056700.0 False True 2335819.6824809974 2018217.9114951384 2994128.571608658 1.0 0.864029842128688 1.2818320669463816 21.155497476576656 -6.81906357674841 1.3757842067000143 0.9266384685053365 1.2907799523972543 0.882221843133989 0.0597138627652688 0.19471873223990643 0.7244318999702515 0.03410822807754948 0.07863952878657843 1.5168283013860523e-07 6.81906357674841 0.3641414838919178 ILGIPTQLYSHHFQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILGIPTQLYSHHFQR 15 0 Q86UA1 Q86UA1 PRPF39 Pre-mRNA-processing factor 39 0 6737800.0 1268300.0 1996200.0 3473300.0 False True 1737224.7845187518 1908001.2834493548 2652978.074858907 1.0 1.0983042036082347 1.527135750365108 20.72835300991756 -6.942888564924281 0.6321251739854546 0.9953212620309212 1.6533144889237021 0.9985182383542379 0.008810032272822654 0.08647332445291112 0.04879279143641607 0.008776723601873572 0.03646506280423422 1.1405424003611897e-07 6.942888564924281 0.657993226892781 ILGIPTQLYSHHFQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILGIPTQLYSHHFQR 15 0 Q86UA1 Q86UA1 PRPF39 Pre-mRNA-processing factor 39 0 7126800.0 2412400.0 2086900.0 2627500.0 False True 2006017.4874405202 2075657.455482784 3176898.10181263 1.0 1.0347155338765852 1.583684151161632 20.935902752010932 -6.919791364609402 0.8262544633289416 0.9877969965600889 1.6717924510251942 0.9941233780172473 0.020494414118167346 0.09829400559343071 0.10624465419968838 0.017638745187564336 0.05273296419479436 1.2028421420962327e-07 6.919791364609402 0.6839954544651053 ILGLGDLGVYGMGIPVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILGLGDLGVYGMGIPVGK 18 0 A0A1W2PQT3;A0A1W2PPH1;A0A1W2PQY8;P23368;A0A1W2PQF8;A0A1W2PQH3;P23368-2;A0A1W2PQ37 A0A1W2PQT3 ME2 NAD-dependent malic enzyme, mitochondrial 0 5576730.0 434630.0 1014800.0 4127300.0 False True 595324.4564341116 969962.7805051625 3152516.744411705 1.0 1.6293010811534074 5.295459829241224 19.183316637157397 -6.9364615237577585 0.6916962260214616 0.9552653246397413 6.189036258753708 0.9976627709924366 0.0915689076881257 0.08941855733150608 0.06224200683529121 0.08690536028370845 0.3207650897537714 1.1575465801825742e-07 6.9364615237577585 5.233770934113966 ILGLLDAYLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILGLLDAYLK 10 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 152787600.0 31516000.0 80615000.0 40656600.0 False True 41317781.201378144 68587556.23480876 36449845.03764556 1.0 1.66000095456532 0.8821830209127925 25.30025944659175 -6.681917658236883 1.8955959806845408 1.4168809393525288 0.8851343841427683 0.33272374933202253 0.27960912295720847 0.43425719603908003 3.0186719502688972 0.1183022964627673 0.3111903197957372 2.0800910327243393e-07 6.681917658236883 -0.5317465552097604 ILGLLDAYLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILGLLDAYLK 10 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 515574100.0 201919100.0 243370000.0 70285000.0 False True 195509288.69542745 340548910.1577843 51875249.9951968 1.0 1.7418553994552435 0.2653339406088794 27.54266191106369 -6.770093998830984 1.5740585392711528 1.4254497961337351 0.2569901039339709 0.7309570650894285 0.31266311465308594 0.26626456680585225 1.3019728231157615 0.156567525027525 0.3726689110963544 1.6978761238597095e-07 6.770093998830984 -1.168459692199764 ILGLLDAYLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILGLLDAYLK 10 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 339080000.0 104570000.0 127550000.0 106960000.0 False True 158640335.09101933 104787705.94730146 85819309.1177666 1.0 0.6605363376670875 0.5409677751155031 27.24118438914114 -13.999999999999998 0.1454232035849762 2.630990420243752 0.4022358896451329 0.999582225300248 0.003974146097755364 11.943475293851355 0.11984502158979919 5.5132595932173425 0.12453156401293955 1.0000000000000041e-14 13.999999999999998 -2.228754530598619 ILGLLDAYLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILGLLDAYLK 10 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 402929860.0 31516000.0 107788760.0 263625100.0 False True 43168316.887875855 103026296.17343667 201362280.90936193 1.0 2.3866183256816385 4.664584941599056 25.36346950811464 -6.9637017078073065 0.37967478323780657 0.8429524111361638 6.288764121743558 0.999883831644265 0.01628297273064286 0.07840432416279347 0.016430579268317206 0.029655507498140336 0.19251614101905182 1.087172083942662e-07 6.9637017078073065 5.445811710607394 ILGLLDAYLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILGLLDAYLK 10 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 354809000.0 201919100.0 84084000.0 68805900.0 False True 167904678.18282685 83631022.8026328 83192895.56746325 1.0 0.49808631723512337 0.49547693648462116 27.323067186497966 ILGLLDAYLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILGLLDAYLK 10 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 311917800.0 104570000.0 128782800.0 78565000.0 False True 135367926.38286406 121615923.97082041 64266976.14497517 1.0 0.8984101863749574 0.47475777949946196 27.01231071123359 -6.9439181408087745 0.6220454757254338 1.0046308889418183 0.346013854858221 0.9986333686331619 0.008409084327599679 0.08602376315895134 0.04680522212554307 0.008452853822215882 0.035881683052865376 1.1378417348446605e-07 6.9439181408087745 -0.6586170340835973 down ILGLLDAYLK(ub)TR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILGLLDAYLKTR 12 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 6557500.0 1500600.0 2780400.0 2276500.0 True False 1967301.1318310727 2365575.1579143167 2040949.6177299654 1.0 1.2024469053766818 1.0374363053562339 20.907786375007724 -10.484391644812009 7.840299081061929 0.9999891247647785 1.1199416053664561 0.41330303966100945 0.06736529536676412 1.2807254603444592e-05 8.422668085233781e-07 0.0652320781246974 0.021742055588985072 3.277995516215056e-11 10.484391644812009 0.11995248060167762 ILGLLDAYLK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILGLLDAYLKTR 12 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 30241830.0 6196700.0 8092130.0 15953000.0 True False 5999989.150402082 11323359.70890047 11774430.720258567 1.0 1.8872300307645804 1.9624086686005955 22.51652846126612 -11.03665268552556 0.44005666186354403 1.398828590276174e-19 1.9640382072206293 0.9996515265665934 0.008158473656388747 2.877759929228311 0.21468268850152616 2.9155562288380006 0.017331851876722558 9.19067300206556e-12 11.03665268552556 1.9640382072206293 ILGLLDAYLK(ub)TR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILGLLDAYLKTR 12 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 152645000.0 35572000.0 49107000.0 67966000.0 True False 53965324.661544815 40343472.17525772 54532490.309443936 1.0 0.7475813854225934 1.0105098162839976 25.68552936764625 -11.064505604613894 11.012000437743726 1.6208081570328863 0.8790456008532955 0.22007069373140664 0.10734008241351425 0.0418661521828614 0.0002452420287532105 0.0026596490891969142 0.03464386263067269 8.619744547670969e-12 11.064505604613894 -0.7417625561795907 ILGLLDAYLK(ub)TR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILGLLDAYLKTR 12 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 8514300.0 1500600.0 0.0 7013700.0 True False 2055412.3721902065 0.0 5357208.511685704 1.0 0.0 2.6063910990168697 20.970996436530616 -6.802709171684716 1.4448952729935696 0.4501388353180638 2.644794755584959 0.8399482329347892 0.4295139018656184 0.21691302560152292 0.893752531198396 0.2338290950209015 0.542910954731857 1.5750372460177518e-07 6.802709171684716 2.194655920266895 ILGLLDAYLK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILGLLDAYLKTR 12 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 23191400.0 6196700.0 8744800.0 8249900.0 True False 5152830.610355936 8697690.026693106 9974915.946772223 1.0 1.6879440999307962 1.9358128960663037 22.296933736700396 -10.762702974691999 0.20722753905139546 4.983771055890761e-20 2.1227882348796827 0.9993465643919566 0.01011950333931857 2.6439339387174385 0.11022961668519772 1.4525782634291582 0.14619803425285555 1.7270186412030224e-11 10.762702974691999 2.1227882348796827 ILGLLDAYLK(ub)TR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILGLLDAYLKTR 12 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 181929000.0 35572000.0 72301000.0 74056000.0 True False 46048655.22894942 68277385.7923131 60578567.878728084 1.0 1.4827226865332896 1.315533919015384 25.4566556897387 -10.21864691407419 5.701130395633763 0.9999859875139251 1.399128302774347 0.8837057862144196 0.0682545285239818 1.215692375823674e-05 1.6661302882451936e-06 0.06608948100790005 0.022029054356379706 6.044398455415413e-11 10.21864691407419 0.399142315260422 ILGLLQTYFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILGLLQTYFR 10 0 Q9NXX6;Q9NXX6-2;Q8N140 Q9NXX6;Q8N140 NSMCE4A;EID3 Non-structural maintenance of chromosomes element 4 homolog A;EP300-interacting inhibitor of differentiation 3 0 8843300.0 2410700.0 2742700.0 3689900.0 False True 3657208.1457771827 2253243.75618709 2960589.6476593753 1.0 0.6161103405582238 0.8095217799068499 21.80231130766192 -10.11391761911981 5.2703271405497665 1.000006140674975 0.7128160602322946 0.7461699495675093 0.0789598894710791 5.697352559489068e-06 9.578445422756971e-07 0.07645421862322158 0.025484194744866805 7.692763496987133e-11 10.11391761911981 -0.28719008044268035 ILGLLQTYFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILGLLQTYFR 10 0 Q9NXX6;Q9NXX6-2;Q8N140 Q9NXX6;Q8N140 NSMCE4A;EID3 Non-structural maintenance of chromosomes element 4 homolog A;EP300-interacting inhibitor of differentiation 3 0 10225600.0 2410700.0 4360000.0 3454900.0 False True 3120698.672001244 4117362.1672519743 2826143.650267603 1.0 1.3193719099484824 0.9056124757009145 21.57343762975437 -6.700581946569339 1.8286629295077086 1.1982078401433152 0.9068264649609563 0.42031022730570955 0.1347973673584148 0.3943616794457419 2.564210441247628 0.058796211186858176 0.15110719566423975 1.9925904908853929e-07 6.700581946569339 -0.29138137518235885 ILGLTASILNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILGLTASILNGK 12 0 Q9UPY3-2;Q9UPY3 Q9UPY3-2 DICER1 Endoribonuclease Dicer 0 2772680.0 757280.0 868600.0 1146800.0 False True 1037266.8807225107 830222.37992391 875949.4590873797 1.0 0.8003941852897266 0.8444783838824923 19.98435570547949 -10.67123027749584 6.662188679145508 1.0011455875903943 0.8224362845861095 0.9558132745351762 0.01799729871196603 0.00030811574137549374 1.5205089034856826e-05 0.017532847621017644 0.00580860318234705 2.131914201011632e-11 10.67123027749584 -0.17870930300428478 ILGPGLNK(ub)AGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILGPGLNKAGK 11 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 8876300.0 2716900.0 3209500.0 2949900.0 True False 3561882.2104970235 2730655.1105330153 2644672.645438886 1.0 0.7666326254376561 0.7424930104776961 21.764208377414015 -13.999999999992212 0.3205731216580989 3.4009769065978803 0.7377311493164778 0.9996949531623336 0.0020280811714290642 18.057992673284517 0.1805907009850601 29.08770939357302 0.00801902044853547 1.0000000000179314e-14 13.999999999992212 -2.663245757281403 ILGPGLNK(ub)AGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILGPGLNKAGK 11 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 11310500.0 3136800.0 3846200.0 4327500.0 True False 3037224.0009975103 5382007.717668034 3193997.9277827996 1.0 1.772015404823757 1.0516175055688353 21.53432188323322 -10.258892721214595 4.278558080569241 0.9997377235268632 1.4118164552057635 0.30348232033434286 0.2941012109984955 207940502.89413285 269.8954606969767 569205.6513366103 0.10067866713108833 5.509437729200397e-11 10.258892721214595 0.4120787316789003 ILGPGLNK(ub)AGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILGPGLNKAGK 11 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 32328600.0 7187000.0 7705600.0 17436000.0 True False 10903204.440079909 6330475.475872399 13989766.957529718 1.0 0.5806068766904644 1.2830876495449064 23.378248868057206 -6.74502212921677 1.668427742969242 0.7519180425238722 1.283955608819818 0.6271751614849279 0.1762054876641335 0.308826997980994 1.68977309167089 0.08348909072425456 0.20374691312992066 1.7987792570674675e-07 6.74502212921677 0.5320375662959459 ILGPGLNK(ub)AGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILGPGLNKAGK 11 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 9183600.0 2716900.0 2576900.0 3889800.0 True False 3721411.351461791 2463044.03733125 2971109.3529456696 1.0 0.6618575063903518 0.7983824071957542 21.827418438936906 -10.210994278531029 6.434283393229814 1.0000022619545264 0.7301199567930527 0.8389752559093857 0.05573605735955463 1.808542736372453e-06 2.2178138363024636e-07 0.0539666573630852 0.017988735161401273 6.151849772074394e-11 10.210994278531029 -0.2698823051614736 ILGPGLNK(ub)AGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILGPGLNKAGK 11 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 11719600.0 3136800.0 5495100.0 3087700.0 True False 2608388.1838017846 5465496.805608044 3733323.7940882435 1.0 2.0953540732736946 1.4312761487237071 21.314727158667495 -10.122647396009164 4.77410397433921 0.9999597509874659 1.763315111001533 0.6378916452949583 0.27110867750721923 0.0001426890113427041 2.6222674018711233e-05 0.2625167727209031 0.08749994940539854 7.539674620047128e-11 10.122647396009164 0.7633553600140671 ILGPGLNK(ub)AGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILGPGLNKAGK 11 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 34467200.0 7187000.0 5796200.0 21484000.0 True False 9303713.176949833 5473636.374730712 17574132.444455482 1.0 0.5883281514193467 1.8889374715458562 23.149375190149655 -6.821590899925788 1.3649754338002222 0.778462533285684 1.9183127049886632 0.888006472007563 0.18163604411732595 0.19141997551942894 0.7003514165767997 0.10455759871277967 0.24089239005487864 1.508026940207635e-07 6.821590899925788 1.1398501717029792 ILGPQGNTIK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILGPQGNTIKR 11 1 Q07666;Q07666-2 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 2863010.0 619250.0 1515600.0 728160.0 True False 811842.7468255297 1289478.3877625281 652816.9882039317 1.0 1.5883351705790942 0.8041175347769983 19.63084078023932 -6.7059028184497125 1.8094976984817863 1.3631865075746266 0.8061462000111225 0.44581271653121846 0.24808449393154525 0.383347304629138 2.4440552642307285 0.10920422270412167 0.2788496456578073 1.968326690510934e-07 6.7059028184497125 -0.5570403075635041 ILGPQGNTIK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILGPQGNTIKR 11 1 Q07666;Q07666-2 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 5655700.0 1286100.0 2479400.0 1890200.0 True False 1245273.4594755478 3469437.3499001907 1395099.915215492 1.0 2.7860847137634805 1.12031610775921 20.248031159254758 -6.6297481720620945 2.081921158898055 2.1769648325350097 1.1270874758640608 0.11637640112246528 0.766195744189879 0.559674813422902 4.622774876521645 0.3010787987201757 0.8485082149612025 2.345588522898026e-07 6.6297481720620945 -1.049877356670949 ILGPQGNTIK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILGPQGNTIKR 11 1 Q07666;Q07666-2 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 2955320.0 619250.0 1394200.0 941870.0 True False 848203.4596020149 1332599.6339971381 719419.7044215474 1.0 1.5710848840706293 0.8481687928496613 19.694050841762213 -6.696096333723039 1.8445374276818807 1.3559591762320207 0.850450394739147 0.3992212266184756 0.24123707434635558 0.40368162365687854 2.667306795401147 0.10444155751706558 0.26992331135528164 2.0132776219433477e-07 6.696096333723039 -0.5055087814928737 ILGPQGNTIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILGPQGNTIKR 11 1 Q07666;Q07666-2 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 5349900.0 1286100.0 3399900.0 663900.0 True False 1069449.133890422 3381584.0638726866 802718.4204732281 1.0 3.1619868179903268 0.7505905564233 20.028436434689034 -6.670329167234441 1.9358884356976882 2.3795346326439435 0.7602279000849034 0.2807294469257423 0.9182824984992907 0.4603025754972139 3.325975929348007 0.38180572470056345 1.0197695988690234 2.1363422659319236e-07 6.670329167234441 -1.61930673255904 ILGPQGNTIK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILGPQGNTIKR 11 1 Q07666;Q07666-2 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 4568500.0 1605600.0 1278400.0 1684500.0 True False 2078480.8511076442 1207255.916196084 1377938.284429586 1.0 0.580835717371524 0.6629545245486713 20.987098025903588 -10.079124237856227 5.205571197762052 1.000006080338513 0.6218951209594422 0.9658316952916702 0.03352486264732214 2.365786803150931e-06 4.1852047952301014e-07 0.03246083041440665 0.01082010289274683 8.334427290228971e-11 10.079124237856227 -0.3781109593790707 ILGSGISSSSVLHGMVFK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ILGSGISSSSVLHGMVFK 18 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 362904600.0 94403800.0 124771800.0 143729000.0 False True 123764296.00769967 106156333.79666713 128857301.82592142 1.0 0.8577298721924043 1.041150848689875 26.883019939549193 -6.69968405816864 1.8322567586738365 0.9116253709566084 1.0405966187467168 0.4159033079821207 0.060057931782657656 0.39621018346881964 2.585832336926901 0.02615336673993892 0.0672792839200866 1.99671436239191e-07 6.69968405816864 0.12897124779010838 ILGSGISSSSVLHGMVFK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ILGSGISSSSVLHGMVFK 18 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 420464000.0 152418000.0 66820000.0 201226000.0 False True 147579574.01939493 93501574.46169671 148518873.94939822 1.0 0.6335671794892749 1.0063647014584813 27.136917815862084 -10.898334383283357 10.871759257230583 1.0141276685941119 0.8199659404754428 0.2371991878424683 0.15219395103309294 0.04997128081644939 0.0004672979878185657 0.141297229783514 0.04912038647872302 1.2637629436076669e-11 10.898334383283357 -0.19416172811866905 ILGSGISSSSVLHGMVFK ddPTM_RPMI8226_Bortezomib_8h_R1 2 ILGSGISSSSVLHGMVFK 18 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 262377100.0 56407000.0 69044100.0 136926000.0 False True 85573542.90407488 56722640.910984546 109862516.08320229 1.0 0.6628525474815126 1.2838374146359062 26.350661486293717 -6.759282326234527 1.615412833031174 0.803991137742041 1.28600785956183 0.6879588070739511 0.14178952457779417 0.2841140255237528 1.4611298238117796 0.06926258385063369 0.16655105676029594 1.7406749272353489e-07 6.759282326234527 0.48201672181978905 ILGSGISSSSVLHGMVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ILGSGISSSSVLHGMVFK 18 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 416561800.0 94403800.0 115874000.0 206284000.0 False True 129307436.0267691 110754303.53592353 157563967.75233778 1.0 0.8565192145097926 1.2185220942724364 26.946230001072085 -6.799218642418561 1.4596021126663417 0.9207561427032861 1.2233946480908604 0.8297179143562707 0.06141990883880752 0.22188422681470749 0.9334053500982201 0.0331088376721513 0.07701870884394826 1.5877472074950362e-07 6.799218642418561 0.3026385053875743 ILGSGISSSSVLHGMVFK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ILGSGISSSSVLHGMVFK 18 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 314438000.0 152418000.0 54794000.0 107226000.0 False True 126742320.26227364 54498813.8462426 129646460.84299198 1.0 0.4299969712836701 1.0229137400570596 26.91732309129636 -10.965961102786851 12.548680289876522 1.102302201033089 0.7264553556703698 0.2210606118058568 0.24205725723909383 0.09815343225006407 0.00026624559992159333 0.03320521531263294 0.07812364384297121 1.0815308133407837e-11 10.965961102786851 -0.3758468453627192 ILGSGISSSSVLHGMVFK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ILGSGISSSSVLHGMVFK 18 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 254434000.0 56407000.0 130481000.0 67546000.0 False True 73019973.44819927 123219617.64798293 55253321.08048734 1.0 1.6874782587451298 0.7566877728281334 26.121787808386166 -6.7088151189193175 1.799224071610929 1.4231483490484675 0.7589292649748077 0.4595827840739526 0.2897528329429407 0.37745326917911726 2.381088481867059 0.12818703154414535 0.32614898939041104 1.9551716038325807e-07 6.7088151189193175 -0.6642190840736598 ILGSGISSSSVLHGMVFKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILGSGISSSSVLHGMVFKK 19 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 22253000.0 12660000.0 1112200.0 8480800.0 False True 16597382.599614393 946264.0953216439 7603288.169577981 1.0 0.05701285064933241 0.45810163885446786 23.984452411308663 -10.699105647766107 6.606954975176819 1.007632512672999 0.2575572488187044 0.820421820901682 0.163743812108969 0.018350663375629243 0.0008357259963217749 0.15803987483041618 0.05284808811187942 1.9993754364600446e-11 10.699105647766107 -0.7500752638542947 ILGVDK(ub)NASEDEIKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILGVDKNASEDEIKK 15 2 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 9940800.0 2466500.0 3370600.0 4103700.0 True False 2388202.307593842 4716498.157446789 3028817.8616388864 1.0 1.9749156687645728 1.268241744850534 21.187493623598485 -10.0884321542588 4.490471188769184 0.9999557932368661 1.6215787066737373 0.5077664900615164 0.2884984214798539 44342215.77655421 49810312.56612064 17743.983150159915 0.09876068360870689 8.157702172854537e-11 10.0884321542588 0.6216229134368711 ILGVDK(ub)NASEDEIKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILGVDKNASEDEIKK 15 2 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 19409100.0 4077000.0 5710800.0 9621300.0 True False 6185107.068624708 4691663.121315945 7719645.837834397 1.0 0.7585419410304827 1.2481022158846642 22.560367138824432 -6.772600389678285 1.5644407678708983 0.8619621128505958 1.2511329234518402 0.7403835102952565 0.10183803543647076 0.2622693870972509 1.2671432415887265 0.051297907303889355 0.12182431150620215 1.688105599022101e-07 6.772600389678285 0.3891708106012445 ILGVDK(ub)NASEDEIKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILGVDKNASEDEIKK 15 2 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 6805400.0 2319600.0 1874600.0 2611200.0 True False 3177218.804833 1791773.9735267803 1994488.3393520815 1.0 0.5639441548064735 0.6277466116964252 21.59933301656088 -10.51255569194654 6.219338856221589 1.000375808171329 0.5958453832514986 0.981651592480677 0.026047243952717136 0.00013585171338419494 1.0647418122222226e-05 0.025242852561064396 0.00840671183695627 3.0721633797656434e-11 10.51255569194654 -0.4045304249198304 ILGVDK(ub)NASEDEIKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILGVDKNASEDEIKK 15 2 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 9933200.0 2466500.0 5429500.0 2037200.0 True False 2051004.0344768893 5400250.205828624 2463169.101051453 1.0 2.632978831368298 1.2009577063946082 20.96789889903276 -6.614490655064099 2.1376194584538175 2.087693208817934 1.2062969408255557 0.06450711124791475 0.7032293472190029 0.6002646532542225 5.204298967768361 0.2710879551271018 0.7799898510532439 2.429457717338975e-07 6.614490655064099 -0.8813962679923781 ILHCLGLAEEIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILHCLGLAEEIQK 13 0 P53004 P53004 BLVRA Biliverdin reductase A 0 18130200.0 4041800.0 9094800.0 4993600.0 False True 5298838.94084688 7737891.291252733 4476910.173993566 1.0 1.4602993934395816 0.8448851199236582 22.337244846399184 -6.706525510556284 1.8078210298754565 1.283983911001741 0.8464876857792838 0.44849942335012805 0.1940765449683974 0.3820928196248244 2.432069492843191 0.08550683918190909 0.21812893345931847 1.9655065228908295e-07 6.706525510556284 -0.43749622522245724 ILHCLGLAEEIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILHCLGLAEEIQK 13 0 P53004 P53004 BLVRA Biliverdin reductase A 0 18873100.0 4041800.0 6913400.0 7917900.0 False True 5536162.685538035 6607943.1284434255 6047855.094269238 1.0 1.1935962694349957 1.0924272709810143 22.400454907922075 -10.111294469347257 4.724526567509308 0.9999909498896528 1.1430117702098073 0.7270985299671122 0.04130207067296575 3.937451775331943e-06 7.407306112999341e-07 0.0399930885468536 0.013330185989146376 7.739368591452987e-11 10.111294469347257 0.1430208203201545 ILHGSVGYLTPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILHGSVGYLTPR 12 0 Q15648-3;Q15648 Q15648-3 MED1 Mediator of RNA polymerase II transcription subunit 1 0 5813700.0 1936200.0 1491400.0 2386100.0 False True 2538376.950187473 1268888.933431669 2139209.2610874022 1.0 0.49988199480693934 0.8427468823845922 21.275474895313696 -10.093057044151605 5.665204874716572 1.0000023920098962 0.6713144385957154 0.5506289584031906 0.1399740042138476 4.229012714838464e-06 6.76969044250184e-07 0.13553023423195387 0.04517641560182279 8.071290076873843e-11 10.093057044151605 -0.3286879534141808 ILHGSVGYLTPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILHGSVGYLTPR 12 0 Q15648-3;Q15648 Q15648-3 MED1 Mediator of RNA polymerase II transcription subunit 1 0 4366010.0 1620800.0 534610.0 2210600.0 False True 1569348.5911810666 748082.5609543195 1631577.5434215267 1.0 0.47668348839649743 1.0396527276286192 20.58173441551777 -11.918665280659054 18.089221251523075 0.9071378022658451 0.7823512972113035 0.0 0.2626834554275316 0.0 0.0 0.0 0.07635011068923403 1.2059650433813702e-12 11.918665280659054 -0.12478650505454159 ILHLLGQEGPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILHLLGQEGPK 11 0 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 0 10885700.0 3770200.0 4535900.0 2579600.0 False True 4942768.710668739 3859161.4007997233 2312687.7372704656 1.0 0.7807691653606815 0.4678931733703492 22.236887968664874 -6.96607133641514 0.3391625523042205 1.034266790198103 0.2040109933025071 0.999933556069589 0.0017798316772048032 0.07759926572891715 0.013588341068434684 0.004428076349510076 0.02709743709130396 1.0812563315285005e-07 6.96607133641514 -0.8302557968955959 down ILHLLGQEGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILHLLGQEGPK 11 0 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 0 19800100.0 7592600.0 9635400.0 2572100.0 False True 7351577.0689791115 13482865.467947211 1898389.8486539894 1.0 1.8340099466330604 0.2582289256905814 22.809622341114725 -6.762932235261124 1.6015554488853876 1.4826865456627494 0.25165808108717236 0.7027285396375262 0.3509495719611609 0.2780455374415559 1.4062528720901175 0.1728460877006433 0.41416232886369325 1.726107202523975e-07 6.762932235261124 -1.231028464575577 ILHLLGQEGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILHLLGQEGPK 11 0 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 0 12616600.0 3770200.0 5640400.0 3206000.0 False True 5164144.825824015 5391188.477691475 2448808.829642608 1.0 1.043965392049444 0.4741944527575995 22.300098030187765 -6.888270932523227 1.032581192763285 1.0318956048852863 0.42682168924397274 0.9797674203640263 0.03681956357830674 0.12055624908180235 0.23014438365557524 0.027229589551113362 0.06747318469576798 1.2933887153874604e-07 6.888270932523227 -0.6050739156413136 down ILHLLGQEGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILHLLGQEGPK 11 0 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 0 16371300.0 7592600.0 6900200.0 1878500.0 False True 6313583.309211111 6863027.25301753 2271285.6647973447 1.0 1.087025689992055 0.35974589287254444 22.590027616549 -6.877014878249297 1.0962515005299924 1.0520815391749796 0.3110538485686589 0.9711995157288587 0.055033098400577664 0.13031007325892782 0.28851013629678296 0.03876770010303683 0.09308373980624568 1.3273489840518676e-07 6.877014878249297 -0.7410276906063207 down ILHLPTSWDWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILHLPTSWDWR 11 0 P53634;H0YCY8 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 15869960.0 6860800.0 8293000.0 716160.0 False True 8994575.24008171 7055716.725860814 642058.6330918043 1.0 0.7844413479826221 0.07138287422741839 23.10062372256337 -7.207190843304431 0.7215927439256187 0.9957206243142891 3.917412504056959e-23 0.9953016487100518 0.02720034148854995 0.0894435424598831 0.08419367088150202 0.024466881905331552 0.05913203298362537 6.205962638566376e-08 7.207190843304431 -0.9957206243142891 down ILHLPTSWDWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILHLPTSWDWR 11 0 P53634;H0YCY8 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 28546500.0 19555000.0 4257400.0 4734100.0 False True 18934237.228865847 5957402.022047704 3494097.190044264 1.0 0.3146364942003291 0.18453857674907556 24.1744939672243 -13.999999999999998 0.23365387495671178 5.400945426712882 0.12344353425245275 0.9995149958842018 0.007877838246724797 13.407833038043174 0.1530266420317552 27.4316505492983 0.0660305729404881 1.0000000000000041e-14 13.999999999999998 -5.277501892460429 ILHLPTSWDWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILHLPTSWDWR 11 0 P53634;H0YCY8 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 16727500.0 3856300.0 6510900.0 6360300.0 False True 5850289.033293455 5348979.02510611 5103183.917181475 1.0 0.91431021521596 0.8722960332625835 22.480076472071215 -13.999999992567794 0.09343142052535838 1.4326638546860013 0.7729465800692058 0.9998260695789913 0.0007008214466924783 12.133596548342219 0.08963396929553577 1.0310934557931928 0.08900377282126404 1.0000000171132867e-14 13.999999992567794 -0.6597172746167955 ILHLPTSWDWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILHLPTSWDWR 11 0 P53634;H0YCY8 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 30847800.0 6860800.0 11897000.0 12090000.0 False True 9397423.166148582 11371351.201882053 9234591.001365906 1.0 1.210049925477865 0.982672679318174 23.16383378408626 -6.663960059324954 1.959002233323617 1.1347658792148072 0.9836162758795591 0.252483653369419 0.08935104402823144 0.47513840427266285 3.509366795126086 0.0367982149085325 0.09908865333643262 2.1679034708033738e-07 6.663960059324954 -0.15114960333524807 ILHLPTSWDWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILHLPTSWDWR 11 0 P53634;H0YCY8 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 29558500.0 19555000.0 5138500.0 4865000.0 False True 16260848.933385603 5110817.880587605 5882249.006781519 1.0 0.3143020331548891 0.3617430449590187 23.954899242658577 -9.954062447631959 7.192149770442443 1.0000000198748416 0.3380225390569533 0.9961628117399894 0.019367711966914246 6.175987577189179e-09 8.936206724067315e-10 0.018752707034371326 0.006250902158499728 1.1115718817723152e-10 9.954062447631959 -0.6619774808178882 ILHLPTSWDWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILHLPTSWDWR 11 0 P53634;H0YCY8 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 26626300.0 3856300.0 10682000.0 12088000.0 False True 4992056.369037368 10087537.309767338 9888108.03335403 1.0 2.0207178292965757 1.9807685054767883 22.251202794163664 -10.139836902931247 5.165707832313276 0.9999639445113319 2.0007431673877174 0.9988062423589719 0.016309243158225344 6.772544701776507e-06 1.1277722615497505e-06 0.015791922798823892 0.005263785594568811 7.247080693815506e-11 10.139836902931247 1.0007792228763854 ILHSLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILHSLLK 7 0 A0A0C4DGQ4;Q86W25 A0A0C4DGQ4 NLRP13 NACHT, LRR and PYD domains-containing protein 13 0 68222000.0 19488000.0 23805000.0 24929000.0 False True 25227600.165910386 22480230.82372322 20392177.793140534 1.0 0.8910966828347138 0.8083280874530478 24.588499637334664 -6.9741671892880035 0.12304911022270364 1.14220095489344 0.5550925814767177 0.9999993795340262 6.155758702594547e-05 0.0749722817084524 0.0036731043078105687 0.0056292233459669504 0.011729131502763087 1.0612869175097613e-07 6.9741671892880035 -0.5871083734167223 ILHVDNHIGISIAGLTADAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILHVDNHIGISIAGLTADAR 20 0 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 521282000.0 138600000.0 210335000.0 172347000.0 False True 210266333.01726377 172799075.89514408 138282539.90762642 1.0 0.8218104791933406 0.6576542136979809 27.647642629247823 -6.972107951729439 0.20157346070313625 1.095747812719791 0.37917676992627364 0.9999944914248473 0.00032806760622535066 0.07562441640892202 0.006521175221763285 0.0052612402211509235 0.017358449077212262 1.0663310324674284e-07 6.972107951729439 -0.7165710427935175 ILHVDNHIGISIAGLTADAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILHVDNHIGISIAGLTADAR 20 0 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 19751800.0 6008900.0 2450900.0 11292000.0 False True 4996666.5894053 2437696.515234442 13653104.991691036 1.0 0.4878645536212523 2.7324426690066628 22.252534524468363 -6.846710313122373 1.250853858742005 0.7272929524185373 2.816640966120815 0.9353834312066975 0.24413838782686384 0.1611108030402744 0.4867445897923931 0.1528473615216256 0.3530353600745037 1.4232778377116342e-07 6.846710313122373 2.0893480137022777 up ILHVDNHIGISIAGLTADAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILHVDNHIGISIAGLTADAR 20 0 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 402524000.0 138600000.0 165643000.0 98281000.0 False True 179420432.21444917 156424821.4381005 80394866.44821855 1.0 0.8718339350065573 0.44808088719866634 27.418768951340272 -6.949247670261319 0.5670478510240835 1.0053510189383514 0.29406560631740486 0.999140876924054 0.006912818150028339 0.08378936445044323 0.03722426898737783 0.007348610650887628 0.03528178612891119 1.12396381499799e-07 6.949247670261319 -0.7112854126209466 down ILHVNGFNGDEK(ub)ATK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILHVNGFNGDEKATK 15 1 P63092-3;A0A590UJF0;A0A590UJG5;H0Y7F4;A0A590UKA4 P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 14635180.0 746280.0 1760500.0 12128400.0 True False 722589.7498930196 2463476.830886215 8951608.195799157 1.0 3.4092330139625373 12.388230247003165 19.462817264380995 -6.946500824968808 0.5960236358644871 0.897914840205347 15.35605803874106 0.9988972859987758 0.1627257363048045 0.0849220212601787 0.04201740126808924 0.167673815819365 0.7536106586966004 1.131095240747394e-07 6.946500824968808 14.458143198535712 ILHVNGFNGDEK(ub)ATK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILHVNGFNGDEKATK 15 1 P63092-3;A0A590UJF0;A0A590UJG5;H0Y7F4;A0A590UKA4 P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 48471300.0 2709900.0 25345600.0 20415800.0 True False 4111116.420227147 20822479.65392334 16380608.181436988 1.0 5.064920942514408 3.9844671147823947 21.97109879661551 -10.407014543937759 7.713256376533129 0.9999059686713679 4.524694028648401 0.9341653406327753 0.44109342809673147 0.0007132681483750372 5.483460502447022e-05 0.42709706910279105 0.14236229176168166 3.917287584191595e-11 10.407014543937759 3.524788059977033 ILHVNGFNGDEK(ub)ATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILHVNGFNGDEKATK 15 1 P63092-3;A0A590UJF0;A0A590UJG5;H0Y7F4;A0A590UKA4 P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 14970200.0 1242100.0 1110700.0 12617400.0 True False 1701337.9364903737 1061625.6014062695 9637429.983509867 1.0 0.6239945507805799 5.6646182847074815 20.6982383010813 -6.888927525986663 1.0286718126221004 0.7221581904230723 6.089212399127902 0.9802041719673493 0.32257637779551285 0.12001901797232054 0.22694792568572408 0.23925834022468548 0.5942371407132794 1.291434767144721e-07 6.888927525986663 5.36705420870483 up ILHVNGFNGDEK(ub)ATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILHVNGFNGDEKATK 15 1 P63092-3;A0A590UJF0;A0A590UJG5;H0Y7F4;A0A590UKA4 P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short 1 24251500.0 2709900.0 16488500.0 5053100.0 True False 3508018.9701149743 15570900.480443608 4133487.64918442 1.0 4.4386591444040215 1.1782968348797003 21.74222511870796 -6.633684010627563 2.0674006247400305 3.2593637190875255 1.191664581063572 0.130818947233022 1.4736393783556778 0.549457843840809 4.480279973567644 0.5820759210296673 1.6318858605474866 2.3244274170071473e-07 6.633684010627563 -2.0676991380239533 ILHVNGFNGDSEK(ub)ATK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILHVNGFNGDSEKATK 16 1 P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;A0A590UK28;A0A590UKA1;A0A590UJA5;A0A590UKA9 P63092-2 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 90871100.0 7211100.0 52646000.0 31014000.0 True False 10939765.902025893 43250909.974924564 24884069.306080926 1.0 3.9535498622429475 2.274643674182529 23.383078530714965 -10.657552638082581 12.226386822744484 0.9998625227144745 3.1140967682127383 0.6788849906923766 0.6854105811248667 0.0025686435079299275 7.194581300908143e-05 0.6636791512326248 0.22121531383424634 2.200125030260934e-11 10.657552638082581 2.1142342454982637 ILHVNGFNGDSEK(ub)ATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILHVNGFNGDSEKATK 16 1 P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;A0A590UK28;A0A590UKA1;A0A590UJA5;A0A590UKA9 P63092-2 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 48093100.0 7211100.0 14123000.0 26759000.0 True False 9334911.102031838 13337042.634885224 21889136.57052618 1.0 1.4287273321737666 2.344868240444388 23.154204852807414 -6.95873015939797 0.45298301957110904 0.971340671816051 2.8387544489534817 0.9997201410434643 0.009383804126000247 0.08015800638533808 0.022831955573197515 0.012300856483889486 0.07574765155820795 1.0996888979530094e-07 6.95873015939797 1.8674137771374308 up ILIANTGMDTDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILIANTGMDTDK 12 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 5508560.0 590360.0 2423200.0 2495000.0 False True 773967.677054372 2061668.0055596202 2236841.3337299656 1.0 2.6637649952076563 2.890096576439878 19.56191379128829 -10.343924600026117 0.42427810945689404 3.554291694563791e-24 2.902971009030747 0.9992634965032057 0.022870617837794784 1.7333951139788382 0.1978983582523723 2.021777345371194 0.05405808053352366 4.52976216477723e-11 10.343924600026117 2.902971009030747 ILIANTGMDTDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILIANTGMDTDK 12 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 4931860.0 590360.0 1618700.0 2722800.0 False True 808632.0458791209 1547180.481674917 2079730.7178262302 1.0 1.9133306546030686 2.571912315897904 19.625123852811182 -7.6916210910373835 0.14521743779422674 1.467405481972e-22 4.02676359134299 0.9999768186235078 0.0031032328277768298 0.1381208957937384 0.01765384156004703 0.1811729394324307 0.26848303971693904 2.0341309554638477e-08 7.6916210910373835 4.02676359134299 ILIANTGMDTDK(ub)IK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILIANTGMDTDKIK 14 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 14994100.0 6292700.0 4845900.0 3855500.0 True False 8146024.197661361 4576221.405111545 3153838.5607707165 1.0 0.5617736080903529 0.3871629256485822 22.957664669179152 -13.999999999999941 0.12695718315807222 3.0825106058473564 0.1329132846042926 0.9996596008624744 0.004756196055977797 11.942489969552325 0.11049201157407575 6.224213291640432 0.22588826394530978 1.000000000000135e-14 13.999999999999941 -2.949597321243064 ILIHSVSLSSSPNIMLLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILIHSVSLSSSPNIMLLHR 19 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 13361700.0 2762000.0 8046100.0 2553600.0 False True 3621008.7472460456 6845653.243452152 2289377.9678608594 1.0 1.8905376157013172 0.6322486709268635 21.78796023125101 -6.71655560244515 1.7714975936296598 1.5437635159593097 0.634548583722402 0.49633485736121996 0.37490739743446405 0.362040241384087 2.218450577425757 0.16815657002412088 0.4238894386890567 1.920633048587726e-07 6.71655560244515 -0.9092149322369077 ILIHSVSLSSSPNIMLLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILIHSVSLSSSPNIMLLHR 19 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 24633000.0 9995900.0 8788400.0 5848700.0 False True 9678585.625979021 12297653.950900564 4316750.012761007 1.0 1.270604448432166 0.44601041718059437 23.206364804895003 -6.818298187959572 1.3791867471379728 1.146113329789959 0.428653501995477 0.8804212369325357 0.11867969832186978 0.195710224167022 0.7319439408513637 0.0676276342146525 0.15594860916765857 1.5195038753371113e-07 6.818298187959572 -0.717459827794482 down ILIHSVSLSSSPNIMLLHR ddPTM_RPMI8226_Bortezomib_8h_R1 2 ILIHSVSLSSSPNIMLLHR 19 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 117134500.0 36464600.0 28777900.0 51892000.0 False True 55319464.11934569 23642258.90224104 41635523.45492841 1.0 0.42737686054289054 0.7526378665762982 25.721283845354552 -10.221789098820182 5.686992242602971 1.0000153849715916 0.5900073635596021 0.6793321996293793 0.13278724966773367 2.5903224357015624e-05 3.544615115800361e-06 0.1285755205557784 0.04285690054597927 6.000824162802854e-11 10.221789098820182 -0.41000802141198944 ILIHSVSLSSSPNIMLLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILIHSVSLSSSPNIMLLHR 19 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 42193000.0 2762000.0 11741000.0 27690000.0 False True 3783186.040243465 11222243.797705065 21150192.293450966 1.0 2.966347326916776 5.59057684937161 21.8511702927739 -6.967126375766244 0.319461367944723 0.6383332182856423 8.003166879265285 0.9999505054925868 0.013229749940682411 0.07724663003988477 0.01235369143474845 0.03986534522118349 0.2309434808047635 1.0786328041680996e-07 6.967126375766244 7.3648336609796425 ILIHSVSLSSSPNIMLLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILIHSVSLSSSPNIMLLHR 19 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 25853000.0 9995900.0 8075200.0 7781900.0 False True 8312033.743453277 8031697.294798298 9409059.31055974 1.0 0.9662734226896302 1.131980403468706 22.98677008032928 -6.853695528038248 1.2170759793548103 0.9819279847444966 1.1390942674668931 0.9455197582240261 0.016689697970149266 0.15343677873822303 0.43550551598392456 0.010719133252056498 0.024871330130132024 1.4005688789272218e-07 6.853695528038248 0.15716628272239652 ILIHSVSLSSSPNIMLLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ILIHSVSLSSSPNIMLLHR 19 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 98947400.0 36464600.0 37438600.0 25044200.0 False True 47204143.52472583 35355108.998825625 20486412.57519232 1.0 0.7489831688251348 0.43399606571532023 25.492410167447 -6.968052827539561 0.30108468447423026 1.0539298735958276 0.11916422969465182 0.9999629620203967 0.0014092448435659999 0.07693970398224825 0.01127957087363665 0.005197821941679368 0.028217484680618174 1.0763342804669247e-07 6.968052827539561 -0.9347656439011758 down ILIIGGSIANFTNVAATFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILIIGGSIANFTNVAATFK 19 0 P53396;P53396-2;K7EIE7 P53396 ACLY ATP-citrate synthase 0 154561000.0 56998000.0 43863000.0 53700000.0 False True 86470133.11196241 36035304.946816824 43086171.46245389 1.0 0.4167370125377041 0.4982780748893433 26.365698574395978 -10.688094699224145 6.763419970835456 1.0042154812379402 0.45750754371386276 0.9833379135134523 0.03328899930766395 0.002123281359089348 9.791825708974647e-05 0.03234281474060355 0.01074397832754106 2.0507149654740843e-11 10.688094699224145 -0.5467079375240775 ILIIGGSIANFTNVAATFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILIIGGSIANFTNVAATFK 19 0 P53396;P53396-2;K7EIE7 P53396 ACLY ATP-citrate synthase 0 102368000.0 56998000.0 20764000.0 24606000.0 False True 73785034.59855098 19608465.146977074 20127960.47888062 1.0 0.2657512496085779 0.2727919094758533 26.136824896488427 -10.115970745861654 7.755349140546896 1.000000101812363 0.26927157954482717 0.999930377837482 0.0028743373545527424 5.062942706388103e-09 5.721712626204906e-10 0.0027830655910908754 0.0009276883921303847 7.656481793450175e-11 10.115970745861654 -0.7307285222675358 ILIRPMYSNPPLNGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILIRPMYSNPPLNGAR 16 1 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 20383400.0 5993800.0 5591500.0 8798100.0 False True 7857929.844041776 4757269.995496291 7887757.009334506 1.0 0.6054100876331264 1.00379580447837 22.905717856730746 -10.951873996681268 11.044679253175218 1.0574621327257965 0.8046029460558293 0.24285468222069717 0.16264028784729126 0.09524755823167315 0.000415030551289699 0.06517826937387532 0.05249192718791162 1.117187334082926e-11 10.951873996681268 -0.2528591866699672 ILIRPMYSNPPLNGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILIRPMYSNPPLNGAR 16 1 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 13642700.0 4050900.0 2235900.0 7355900.0 False True 3922306.3968505575 3128706.530064462 5429169.117730211 1.0 0.7976700985360752 1.384177718010403 21.903270807544494 -6.813568794200463 1.399536129693927 0.8901867589608149 1.3952914442298683 0.8689197199303329 0.0880675335009013 0.2019803517779523 0.7790331812652667 0.049470093412727324 0.114257736372266 1.5361414423403354e-07 6.813568794200463 0.5051046852690534 ILIRPMYSNPPLNGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILIRPMYSNPPLNGAR 16 1 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 20493700.0 5993800.0 6615600.0 7884300.0 False True 8209869.836354569 6323300.917136329 6022190.722255517 1.0 0.770207207078458 0.7335305969880702 22.968927918253637 -13.999999999999998 0.2582741251166591 2.667165317646741 0.719902275725695 0.9995588301809446 0.002476886065850166 14.341603424814881 0.16081806163438736 12.466098087949353 0.016181746496019743 1.0000000000000041e-14 13.999999999999998 -1.9472630419210462 ILIRPMYSNPPLNGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILIRPMYSNPPLNGAR 16 1 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 8719100.0 4050900.0 2601900.0 2066300.0 False True 3368502.8352979664 2587883.048263285 2498353.776508257 1.0 0.7682591272138174 0.7416807699635678 21.68367608297877 -13.999999999999998 0.30564176284932154 3.1839012496033554 0.735515641482478 0.9996623750867534 0.0021317511498226455 16.965291523483803 0.1757522063442263 23.505777471219798 0.009378055993948215 1.0000000000000041e-14 13.999999999999998 -2.4483856081208772 ILITTVPPNLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILITTVPPNLR 11 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 19278900.0 4206600.0 6033300.0 9039000.0 False True 5514893.336772341 5133155.157619199 8103730.988210475 1.0 0.9307804964045671 1.4694266041695165 22.394901552330733 -6.874619699790617 1.1094322304134001 0.9595181379245177 1.5038612920997574 0.9690771957056591 0.04207702307226417 0.13249940080564707 0.3020334263833452 0.02934478383621777 0.07008540017542608 1.3346896730913685e-07 6.874619699790617 0.5443431541752397 ILITTVPPNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILITTVPPNLR 11 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 15892900.0 4759200.0 2670100.0 8463600.0 False True 4608121.801054369 3736284.8543875567 6246729.257442514 1.0 0.8108042746467053 1.3555911773020455 22.135747419666632 -6.812917730672181 1.4022919763446928 0.8972390505348297 1.3657655941194926 0.867287308615856 0.08227291190712119 0.20285461154937945 0.7856296524357113 0.04612592491502773 0.10656180459796796 1.538446043809226e-07 6.812917730672181 0.46852654358466295 ILITTVPPNLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILITTVPPNLR 11 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 16811000.0 4206600.0 5911600.0 6692800.0 False True 5761893.699090568 5650405.964953013 5112098.482542742 1.0 0.9806508519664026 0.8872254070479664 22.458111613853625 -6.940590352711856 0.6540790573736741 1.0010389830505086 0.8615905280849134 0.9982398052686482 0.0020658218441567972 0.08749906726575774 0.05339731232722265 0.002019987799284478 0.008020294981201156 1.1465939536886513e-07 6.940590352711856 -0.13944845496559521 ILITTVPPNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILITTVPPNLR 11 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 9666800.0 4759200.0 2628600.0 2279000.0 False True 3957485.6683082916 2614439.2100637536 2755528.3630945724 1.0 0.6606313778974087 0.6962825879979698 21.91615269510091 -9.851864758741721 6.559949575445175 1.000000009452138 0.6784569832323729 0.9908642151712207 0.014554545576615424 2.024928073913431e-09 3.201134626328255e-10 0.014092378787398873 0.004697459385806918 1.406485441844789e-10 9.851864758741721 -0.32154302621976505 ILK(ub)AALDHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILKAALDHK 9 1 Q99707;Q99707-2;B1ANE3 Q99707 MTR Methionine synthase 1 1504540.0 475950.0 403970.0 624620.0 True False 651921.5770651269 386121.2696498519 477097.6204527031 1.0 0.5922817762653658 0.73183284192025 19.314338900267284 -10.392895078787559 5.147669577839364 1.0002533188596894 0.6620573090927888 0.8866101535525677 0.05697148398608317 0.00016575209483019572 1.9548314029744157e-05 0.05520324913988617 0.018387467390559003 4.046736450027263e-11 10.392895078787559 -0.33819600976690056 ILK(ub)CAGNEDIITLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILKCAGNEDIITLR 14 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 67398000.0 21345000.0 33871000.0 12182000.0 True False 27983501.705274057 28817578.82812389 10921523.497995352 1.0 1.0298060311262844 0.39028437588055576 24.73807316912796 -6.895966027884405 0.9863795320730583 1.0296110131518712 0.32838543857034386 0.9844514552843061 0.03674718548615565 0.11443727995912412 0.19462054252577465 0.02813848682645736 0.07183961527542301 1.270673498086979e-07 6.895966027884405 -0.7012255745815273 down ILK(ub)CAGNEDIITLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILKCAGNEDIITLR 14 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 92447000.0 21345000.0 39949000.0 31153000.0 True False 29236823.32693587 38183921.08632316 23795303.016174693 1.0 1.3060215420580366 0.8138812739704212 24.801283230650853 -6.738533228115443 1.691914497813881 1.1823916528548302 0.8136765786571538 0.5983653857626511 0.1285829492294577 0.3204964733870428 1.8008096270540017 0.06013426775329953 0.14781100992890017 1.8258570463795676e-07 6.738533228115443 -0.36871507419767635 ILK(ub)CAGNEDIITLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILKCAGNEDIITLR 14 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 69896000.0 28664000.0 16171000.0 25061000.0 True False 23835386.03050699 16083883.613307828 30301139.231028102 1.0 0.6747901457405393 1.2712669806247556 24.506601655249003 -6.758662066547682 1.6175500033601622 0.8107834766505625 1.2732990987705899 0.6854466516316265 0.13675911972700333 0.28518070436829 1.4703208650247754 0.06671861155468131 0.1605450822315228 1.743162736522684e-07 6.758662066547682 0.4625156221200274 ILK(ub)DGDTLNQHGIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILKDGDTLNQHGIK 14 1 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 10136800.0 3185100.0 4654300.0 2297400.0 True False 4175696.9445522744 3959896.5823193067 2059687.0862169208 1.0 0.948319917585373 0.4932558836445359 21.99358557997314 -6.928357975760544 0.7601624305675487 1.0073585970646264 0.4036275663203814 0.9962052467620325 0.01402544488392661 0.0934999730360413 0.0819271626620154 0.012655086078219992 0.04155364299950091 1.1793481340314803e-07 6.928357975760544 -0.603731030744245 down ILK(ub)DGDTLNQHGIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILKDGDTLNQHGIK 14 1 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 15571300.0 4285700.0 5404900.0 5880700.0 True False 4149652.799373575 7563104.756181145 4340368.25278158 1.0 1.8225873637724244 1.0459593760318442 21.984559200825508 -10.36152754521471 4.185623212795369 0.9990766676101339 1.4342733699090666 0.29423731637063766 0.3170570483446636 31762041.41390662 78631178.4223685 175909.8753609125 0.10853706482486185 4.3498317086081794e-11 10.36152754521471 0.4351967022989327 ILK(ub)DGDTLNQHGIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILKDGDTLNQHGIK 14 1 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 10539800.0 3185100.0 3955300.0 3399400.0 True False 4362717.544091043 3780541.7675720016 2596531.732840634 1.0 0.8665566196675848 0.5951638414816544 22.05679564149603 -6.959716012799186 0.4394176550336204 1.0097629794114316 0.44138649277523584 0.9997595207233315 0.0026120856480471738 0.07980272587409959 0.021507315562526837 0.003575580471520259 0.02248908605318664 1.0971954228572238e-07 6.959716012799186 -0.5683764866361958 ILK(ub)HILTQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILKHILTQR 9 1 Q14181;A0A3B3ITS5;Q14181-2;H0YDR7 Q14181 POLA2 DNA polymerase alpha subunit B 1 5332200.0 1282100.0 1182800.0 2867300.0 True False 1241400.4372860596 1655098.2082205166 2116268.1128438152 1.0 1.3332508661257443 1.704742522461475 20.24353712854851 -6.969721150097541 0.2647605738140734 0.9015826454731848 2.147501445602314 0.9999801254311111 0.0012832531255714767 0.07639326284377533 0.009353361939421554 0.0075229735941180435 0.03480650020660523 1.0722075225892074e-07 6.969721150097541 1.245918800129129 ILK(ub)HILTQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILKHILTQR 9 1 Q14181;A0A3B3ITS5;Q14181-2;H0YDR7 Q14181 POLA2 DNA polymerase alpha subunit B 1 15872600.0 2895300.0 3800200.0 9177100.0 True False 4392381.774782706 3122024.618901882 7363242.16253418 1.0 0.7107817077344855 1.6763666138511935 22.06657202454357 -6.826409025561958 1.3437902752711044 0.8450304701201085 1.7005090191276466 0.8985050307442257 0.12890570183435074 0.1852940172299606 0.6556236802974662 0.07534209503134624 0.17343897141933332 1.4913891335378012e-07 6.826409025561958 0.8554785490075382 ILK(ub)HILTQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILKHILTQR 9 1 Q14181;A0A3B3ITS5;Q14181-2;H0YDR7 Q14181 POLA2 DNA polymerase alpha subunit B 1 6146300.0 1282100.0 2860800.0 2003400.0 True False 1066122.956660377 2845388.302575662 2422301.677324993 1.0 2.6689119531660976 2.272065958426443 20.023942403982787 -10.177423243131654 5.133872210535862 0.9999120050890445 2.470488955797413 0.9482054369128184 0.16201169893387446 11525356.777211575 22847963.994120434 8180.809156413666 0.05546091456898913 6.646251278552718e-11 10.177423243131654 1.4705769507083684 ILK(ub)HILTQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILKHILTQR 9 1 Q14181;A0A3B3ITS5;Q14181-2;H0YDR7 Q14181 POLA2 DNA polymerase alpha subunit B 1 14983300.0 2895300.0 3302800.0 8785200.0 True False 3748022.9248953396 3118996.2766054673 7186383.743764218 1.0 0.8321710776869281 1.9173798794106607 21.83769834663602 -6.867420882301111 1.1477176419925348 0.9064208936080711 1.9778784316369105 0.9620371213040375 0.09293149011729578 0.13934821963174024 0.34469171166214524 0.06293543494001318 0.1483636415348571 1.3569977191604312e-07 6.867420882301111 1.0714575380288394 ILK(ub)LPSFELLHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILKLPSFELLHK 12 1 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 1 27376500.0 2073800.0 8397700.0 16905000.0 True False 3146106.2150880336 6899064.82347042 13563719.340275297 1.0 2.192889989023264 4.311271906595741 21.58513594745033 -6.962301207809659 0.40168749288767097 0.8856952912622663 5.696028254530907 0.9998462566407961 0.016978504682590136 0.0788890878608931 0.018167466156336028 0.02725300880476129 0.17737532359849065 1.0906836232284177e-07 6.962301207809659 4.810332963268641 ILK(ub)LPSFELLHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILKLPSFELLHK 12 1 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 1 26787600.0 2073800.0 7251800.0 17462000.0 True False 2684574.9807094126 6848230.955155473 14284095.175250491 1.0 2.550955367000326 5.320803210151294 21.35626226954278 -6.962197205135976 0.4032741327111715 0.8531289852517422 7.120304589553844 0.999843209968206 0.022378612791594265 0.0789253744359839 0.018298384616534914 0.03563274013076196 0.23179096807110733 1.090944845972604e-07 6.962197205135976 6.267175604302102 ILK(ub)SLGELGLEHFQAPLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILKSLGELGLEHFQAPLVR 19 1 A0A087X028;A0A0A0MRN5;Q9NZT2-2;Q9NZT2 A0A087X028 OGFR Opioid growth factor receptor 1 3754000.0 935800.0 1676400.0 1141800.0 True False 906093.5412310212 2345795.2623105124 842728.3267342346 1.0 2.588910698031804 0.930067689909037 19.789300470076938 -6.656016141929864 1.9879293828652422 2.0261379849405423 0.9371378124614616 0.21853522552590854 0.6771788231178603 0.4938954792184271 3.7480224071039183 0.27568115755727146 0.7499797095793496 2.2079226670552084e-07 6.656016141929864 -1.0890001724790808 ILK(ub)SPEIQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILKSPEIQR 9 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 47989300.0 11130300.0 16544400.0 20314600.0 True False 14591931.08597854 14076040.0095661 18212640.063403096 1.0 0.9646454555347947 1.2481308989256201 23.798667485356997 -6.875644188487676 1.1037524860026608 0.9791271974600856 1.2666198397764932 0.970001243160487 0.021846200311904426 0.13156091648251161 0.29616830101728364 0.015301269057449541 0.03662748673126242 1.3315448876769232e-07 6.875644188487676 0.2874926423164076 ILK(ub)SPEIQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILKSPEIQR 9 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 95045300.0 21385700.0 25246500.0 48413100.0 True False 20706822.65944035 35327559.10875827 35732256.74813203 1.0 1.7060830475916715 1.7256272164885473 24.303602861655065 -11.236770953717423 0.5942081515228884 4.5368192162271443e-10 1.723322006610315 0.9999335586214179 0.0027514308860792976 3.5781155908628945 0.29434247005709546 4.739903235235268 0.003425913166100195 5.797343668825978e-12 11.236770953717423 1.723322006156633 ILK(ub)SPEIQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILKSPEIQR 9 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 39719300.0 13344400.0 5977900.0 20397000.0 True False 20244430.406317286 4911097.0394541165 16365524.009677324 1.0 0.24259003295650175 0.8083963678509055 24.27102171638661 -10.163534793985303 7.204791901458052 1.000000446359411 0.5254932004062978 0.4839380927606308 0.23098946895426437 1.65627077358265e-06 1.9242904998941773e-07 0.22365480155089998 0.07455153053409674 6.86222898698593e-11 10.163534793985303 -0.4745072459531132 ILK(ub)SPEIQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILKSPEIQR 9 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 50689500.0 11130300.0 15100700.0 24458500.0 True False 15245472.695047757 14433501.14266287 18681906.03861938 1.0 0.9467401523962821 1.2254068084545449 23.86187754687989 -6.857206574079453 1.1997794800328818 0.9712916324274005 1.2381980609521024 0.9501523997056228 0.026967031178032754 0.14970751658546655 0.41109217298221895 0.017549546101523036 0.04084528992114333 1.3892916513456098e-07 6.857206574079453 0.2669064285247019 ILK(ub)SPEIQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILKSPEIQR 9 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 93168200.0 21385700.0 53952400.0 17830100.0 True False 17783157.097146727 53661747.71248714 21558291.472932216 1.0 3.0175602351900195 1.2122870733898652 24.08400813708934 -6.619589144367818 2.119426253048332 2.3391614233200166 1.2193130758023827 0.08109676969817314 0.8677280630574896 0.5864430318218783 5.005656384252713 0.33657674094495094 0.9615373474077102 2.40110336083926e-07 6.619589144367818 -1.119848347517634 ILK(ub)SPEIQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILKSPEIQR 9 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 29341000.0 13344400.0 10204600.0 5792000.0 True False 17274588.85744947 9636705.03943567 4737915.43093866 1.0 0.5578543789932199 0.2742708072554496 24.04214803847906 -8.411536549416706 0.22407451172959886 1.2623191691165114 2.9829309906785965e-12 0.9995927399566847 0.0060264664222089434 0.12600311501938563 0.05473882600069974 0.12786831482908786 0.11562199743483369 3.8767112145617226e-09 8.411536549416706 -1.2623191691135285 down ILKLPSFELLHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILKLPSFELLHK 12 1 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 6168930.0 3078900.0 794830.0 2295200.0 False True 4036467.716110014 676244.4622230745 2057714.721113032 1.0 0.16753372249804052 0.509781042692464 21.94466192231581 -10.579399743286139 6.3887493087589 1.0013593049876601 0.33865738267434814 0.8327381749165932 0.13972188338521174 0.002709670522499691 0.00017838951966905433 0.1355088069539114 0.045095043954304984 2.6339059096631468e-11 10.579399743286139 -0.6627019223133119 ILKLPSFELLHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILKLPSFELLHK 12 1 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 6856800.0 3078900.0 2623800.0 1154100.0 False True 4217252.534143958 2507871.8402536884 881525.3494355987 1.0 0.5946695911495256 0.20902835253486562 22.0078719838387 -7.678927408446424 0.3449402548702227 1.0701526966713792 2.6421488782845312e-11 0.9991332688777591 0.009507629568258482 0.12255706270994586 0.04977691836868412 0.029855764866094446 0.07564709833369024 2.094462512294353e-08 7.678927408446424 -1.0701526966449577 down ILKLPSFELLHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILKLPSFELLHK 12 1 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 14694000.0 1691600.0 5486100.0 7516300.0 False True 2189809.546421083 5180793.712330519 6148410.523750729 1.0 2.365864977069697 2.8077375650313465 21.062373969569773 -9.945619824348649 0.2817442615339593 7.909393663664202e-15 2.993984646022716 0.9989395290751425 0.025057684525195353 1.3627632587264642 0.1252675919007571 1.2763057010614713 0.16971233020834592 1.1333920855586966e-10 9.945619824348649 2.993984646022708 ILLANFLAQTEALMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILLANFLAQTEALMR 15 0 P06744;A0A2U3TZU2;P06744-2;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 51460000.0 14092000.0 21919000.0 15449000.0 False True 21378594.263198283 18007383.196071338 12395498.378462765 1.0 0.8423090393305119 0.5798088604825027 24.34966365683085 -6.963468751383603 0.3834252477911719 1.0173510243558035 0.3954335098891528 0.9998780169453189 0.0019141517154796814 0.07848449165648815 0.016716318064641418 0.00340511178725008 0.022145358521828952 1.087755401642771e-07 6.963468751383603 -0.6219175144666507 ILLANFLAQTEALMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILLANFLAQTEALMR 15 0 P06744;A0A2U3TZU2;P06744-2;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 30528800.0 14092000.0 9614900.0 6821900.0 False True 18242371.79484862 9079822.362823637 5580384.198605054 1.0 0.49773255719892995 0.30590233887135626 24.1207899789233 -13.999999999999902 0.13337795628676968 3.389030415516234 0.04843617792257371 0.9996306011743993 0.005624827815886711 11.932979150179042 0.11389201927244869 7.4525417203433815 0.22929988681229388 1.000000000000225e-14 13.999999999999902 -3.34059423759366 ILLDIHIFMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 ILLDIHIFMK 10 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 31171500.0 6309600.0 12824300.0 12037600.0 False True 9572124.493547803 10535703.46828676 9658363.083732499 1.0 1.1006651110094179 1.0090093469054677 23.190407729787722 -10.855178751786209 3.9879289975125065 0.9854943015257547 1.0548372289574808 0.3230787082533175 0.03741830900671306 0.0060104079192588675 0.00021826732120869982 0.04512342031949102 0.012076707302170968 1.3957937463902649e-11 10.855178751786209 0.0693429274317261 ILLDIHIFMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ILLDIHIFMK 10 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 21698100.0 6309600.0 6967100.0 8421400.0 False True 8167901.580810151 6579374.760426884 6888791.610860987 1.0 0.8055159205008803 0.8433979698097326 22.96153405188017 -10.379890857186869 5.831285541450477 1.0000424962074275 0.8244569451553074 0.9662517510292711 0.01546528186960767 8.546311588791951e-06 9.088455926567489e-07 0.014977814969319615 0.004991398260449357 4.169741603364893e-11 10.379890857186869 -0.17558555105212004 ILLGLNFYGMDYATSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILLGLNFYGMDYATSK 16 0 Q9BWS9-3;Q9BWS9;E9PPA0;Q9BWS9-2;H0YC89 Q9BWS9-3 CHID1 Chitinase domain-containing protein 1 0 13647100.0 5065600.0 0.0 8581500.0 False True 7684885.544965733 0.0 6885362.763594928 1.0 0.0 0.8959616539904669 22.873592342585702 -9.14124051586275 10.389239522776824 1.0 0.44798082699514713 0.33604984105513946 0.36577481356309677 0.0 0.0 0.3541599403478578 0.11805331344928591 7.223696385467508e-10 9.14124051586275 -0.5520191730048529 ILLGLNFYGMDYATSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILLGLNFYGMDYATSK 16 0 Q9BWS9-3;Q9BWS9;E9PPA0;Q9BWS9-2;H0YC89 Q9BWS9-3 CHID1 Chitinase domain-containing protein 1 0 27877700.0 8993900.0 8897600.0 9986200.0 False True 11642780.846273677 8402440.738380997 8168814.067064864 1.0 0.7216867558810259 0.7016205299165558 23.472932347369515 -13.999999999999979 0.37326238202782686 4.957112153627341 0.6996457443126477 0.9997964309695448 0.0019428954512101784 23.206338479791647 0.198607841995127 73.58152264594601 0.005551611833421118 1.000000000000049e-14 13.999999999999979 -4.257466409314693 ILLLGLDNAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILLLGLDNAGK 11 0 P36405 P36405 ARL3 ADP-ribosylation factor-like protein 3 0 5281600.0 0.0 1806200.0 3475400.0 False True 0.0 1536722.000512455 3115798.946390826 0.0 ILLLGLDNAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILLLGLDNAGK 11 0 P36405 P36405 ARL3 ADP-ribosylation factor-like protein 3 0 3269000.0 0.0 0.0 3269000.0 False True 0.0 0.0 2496929.527168332 0.0 ILLLITSSHSDYCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILLLITSSHSDYCR 14 0 Q5TFE4;Q5TFE4-2;H0YDA5 Q5TFE4 NT5DC1 5-nucleotidase domain-containing protein 1 0 36481500.0 6932500.0 12654000.0 16895000.0 False True 10517109.33363767 10395794.833846744 13555695.844658453 1.0 0.9884650338850318 1.288918410432631 23.326234893262725 -6.897969797351399 0.9739953831775553 0.9868029309015314 1.319189355164604 0.985529451246216 0.016720334266532504 0.11291575836420026 0.18595964320216865 0.012922516387064802 0.03329309020749495 1.2648243055671802e-07 6.897969797351399 0.3323864242630725 ILLNACCPGWVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILLNACCPGWVR 12 0 P16152 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 21083400.0 5319800.0 7191800.0 8571800.0 False True 7286673.822189425 6874042.495897727 6547317.381762469 1.0 0.9433717857611315 0.8985330675601997 22.79682898122922 -6.9737556754987295 0.14224562974281604 1.0581577608460446 0.7825753839583247 0.9999988278841692 4.457553280291481e-05 0.07510165031351049 0.0043164666470143186 0.0024759344813241693 0.005780994626088871 1.062293011755196e-07 6.9737556754987295 -0.2755823768877199 ILLSHFNWDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILLSHFNWDK 10 0 Q9Y4X5;H3BNB9;H3BSK4 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 0 18056300.0 3759800.0 4753100.0 9543400.0 False True 4929134.209954989 4043956.007438685 8555940.514756922 1.0 0.8204191314716937 1.7357897249941285 22.232902832419033 -6.855774069769007 1.2068401355796898 0.9034590280115571 1.7766821665843133 0.9483000428580521 0.09004721743155186 0.15121997842497917 0.4209299318558487 0.0582854520155411 0.13547763752232353 1.3938817445170388e-07 6.855774069769007 0.8732231385727562 ILLSHFNWDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILLSHFNWDK 10 0 Q9Y4X5;H3BNB9;H3BSK4 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 0 10026900.0 3551700.0 1243900.0 5231300.0 False True 3438953.2276022905 1740595.756852804 3861065.5943639884 1.0 0.5061411544891476 1.1227444337927224 21.71353806356483 -6.693444867851716 1.8543268386737246 0.6913863864268157 1.1206981552969288 0.38655646375163566 0.20872363914711495 0.40928984879503155 2.7312488597015623 0.08996156090130074 0.23324094513667545 2.0256067341138118e-07 6.693444867851716 0.42931176887011313 ILLSHFNWDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILLSHFNWDK 10 0 Q9Y4X5;H3BNB9;H3BSK4 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 0 8526900.0 3551700.0 2464200.0 2511000.0 False True 2953395.91698827 2450924.865494598 3036038.490447767 1.0 0.8298666803853147 1.0279822197166752 21.493943338999106 -6.679430354212327 1.9041856844956953 0.892298798537168 1.0272201835986372 0.32143754346653053 0.07211561788970182 0.43976602595143505 3.0825037541437816 0.030396517649953027 0.08021928003467264 2.0920383706744925e-07 6.679430354212327 0.13492138506146922 ILLSHFNWDK(ub)EK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILLSHFNWDKEK 12 1 Q9Y4X5;H3BNB9;H3BSK4 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 22314300.0 10437000.0 9246500.0 2630800.0 True False 10105683.147924948 12938675.669860508 1941714.5576917343 1.0 1.2803365671045477 0.1921408507736992 23.268663515945036 -6.838324829729182 1.2900518902529141 1.1491851377391313 0.15749790384571977 0.9215513480255878 0.129211346525348 0.1707644779971298 0.55275298335378 0.07855718108348707 0.18091750095724593 1.4510259195472432e-07 6.838324829729182 -0.9916872338934115 down ILLSHFNWDK(ub)EKLMER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILLSHFNWDKEKLMER 16 2 Q9Y4X5;H3BNB9 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 28194400.0 10772000.0 4743400.0 12679000.0 True False 16341911.538686596 3896903.20964664 10172990.092596885 1.0 0.23846067214483496 0.6225091886291345 23.962073411837554 -10.707586541194985 6.713490534514239 1.0061999791974348 0.4304849303945439 0.7456821888420335 0.15678715030989798 0.014573958345281498 0.0006347840388567243 0.15206270074214312 0.05060283517079619 1.9607104287871558e-11 10.707586541194985 -0.5757150488028908 ILLSHFNWDK(ub)EKLMER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILLSHFNWDKEKLMER 16 2 Q9Y4X5;H3BNB9 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 29009600.0 10772000.0 8876200.0 9361400.0 True False 13944566.347864674 8382231.667193117 7657721.256075481 1.0 0.6011109602183279 0.5491544925129999 23.733199733930004 -13.999999999999998 0.28732749535243657 4.385990644197391 0.5346110420505659 0.9996214846732158 0.003918413195579525 15.808858590408162 0.16993079402168534 31.590903005084158 0.019862557160320874 1.0000000000000041e-14 13.999999999999998 -3.8513796021468254 ILLSQTTGVAIPLHASSLDDVSLASTPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILLSQTTGVAIPLHASSLDDVSLASTPK 28 0 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 0 43757200.0 5609900.0 28601000.0 9546300.0 False True 8510628.438625889 23496928.08936705 7659469.620708066 1.0 2.7608922488878886 0.8999887230354461 23.020834236113693 -6.658630553434634 1.9777283953419451 2.1347068988928273 0.9077490716304074 0.22991409339118163 0.7499865268332536 0.48762640901496185 3.6650580967717934 0.30652982099802156 0.8312916727047803 2.194671109024089e-07 6.658630553434634 -1.22695782726242 ILLSQTTGVAIPLHASSLDDVSLASTPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILLSQTTGVAIPLHASSLDDVSLASTPK 28 0 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 0 9641300.0 4469600.0 2001000.0 3170700.0 False True 3716670.4368529883 1990220.2158325976 3833678.7103395974 1.0 0.535484716669626 1.0314820147426587 21.825579337104934 -11.798093086947109 13.762214520257077 0.9040812214509955 0.8051350291354263 0.0 0.23231918113953695 0.0 0.0 0.0 0.067432558264747 1.5918674886225295e-12 11.798093086947109 -0.09894619231556911 ILLSSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILLSSGR 7 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 5120600.0 1162800.0 2152000.0 1805800.0 False True 1524442.0605712198 1830929.9884303005 1618953.1384567413 1.0 1.2010492466628988 1.0619971597018962 20.539849888241836 -10.485034396994847 4.885161322362986 0.9995988452237756 1.1315232031823683 0.5439739577311236 0.05676777678730079 0.00024877610039975907 2.622461049700695e-05 0.05513170494974413 0.01832172117486409 3.273147698653121e-11 10.485034396994847 0.1319243579585927 ILLSSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILLSSGR 7 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 5694100.0 1162800.0 2200100.0 2331200.0 False True 1592718.5834884534 2102892.3072422193 1780618.572571066 1.0 1.320316300093867 1.117974381055481 20.603059949764727 -10.151484297854974 3.7792162371547677 0.9998648967037834 1.2191453406298307 0.6099815111594322 0.08260574320100963 58250718.29408421 96829754.6068353 94652.6296200193 0.030230608825460876 7.05530352409856e-11 10.151484297854974 0.21928044392604729 ILLTEPPMNPTK(ub)NR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILLTEPPMNPTKNR 14 1 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 1 174960900.0 73109000.0 96683000.0 5168900.0 True False 95846606.98856314 82258273.26738228 4634071.811589901 1.0 0.8582283280742293 0.048348835260729264 26.51422402497907 -7.11969101361045 0.8419789443066396 0.9973203539396515 1.0218095107648693e-18 0.994117258462886 0.03215310975069654 0.08205450351641179 0.10432099233115687 0.02817789218262315 0.060115090267508976 7.591174703217332e-08 7.11969101361045 -0.9973203539396515 down ILLTEPPMNPTK(ub)NR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILLTEPPMNPTKNR 14 1 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 1 156331300.0 70696000.0 77541000.0 8094300.0 True False 68451794.17703384 108503525.67097318 5974160.006205037 1.0 1.5851085713013646 0.08727543343501461 26.028585020397212 -6.800761281150108 1.4527516174358919 1.3225300109123996 0.06620042328885672 0.8343675578522556 0.25083957845628596 0.21968939807253257 0.9152744839828835 0.13582726547704801 0.31574597056929443 1.582117443536724e-07 6.800761281150108 -1.256329587623543 ILLTEPPMNPTK(ub)NR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILLTEPPMNPTKNR 14 1 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 1 215623000.0 127550000.0 20292000.0 67781000.0 True False 193502675.15405482 16670734.05788034 54384055.64053232 1.0 0.0861524733164962 0.28105066556436553 27.527778270713082 -10.387079086680828 8.495402025436352 1.0000050686533768 0.1836015694404348 0.9590083903918025 0.07956685379968997 7.638527292968382e-06 5.512049405816515e-07 0.0770407528701415 0.025680091639693294 4.1012941005676023e-11 10.387079086680828 -0.816403499212942 ILLTEPPMNPTK(ub)NR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILLTEPPMNPTKNR 14 1 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 1 136436000.0 73109000.0 56825000.0 6502000.0 True False 100139372.99643727 54314283.604853936 4966361.512893398 1.0 0.5423868951804434 0.0495944937968614 26.577434086501963 -7.813479423877729 0.533208719653438 1.0159024601575894 1.3963999510640396e-21 0.9933552579185716 0.031635268509579983 0.11193958700358131 0.11823608409192712 0.036156452570243934 0.07732841342758077 1.536457586313255e-08 7.813479423877729 -1.0159024601575894 down ILLTEPPMNPTK(ub)NR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ILLTEPPMNPTKNR 14 1 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 1 225059400.0 99941000.0 113867700.0 11250700.0 True False 83105369.63699766 113254272.09913132 13603169.352640675 1.0 1.362779235491321 0.16368580528621685 26.308438360201073 -6.825537179598386 1.3475593342601078 1.1945228246781605 0.13422372077254832 0.896690276887293 0.1613811253110645 0.18637840306625328 0.6634344020199167 0.0940659308590596 0.21657505690344664 1.4943861037077732e-07 6.825537179598386 -1.0602991039056122 down ILLTEPPMNPTK(ub)NR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILLTEPPMNPTKNR 14 1 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 1 210102000.0 127550000.0 28128000.0 54424000.0 True False 165115989.38638526 26562652.073500823 44519390.43739735 1.0 0.1608726821200943 0.2696249503324493 27.29890459280553 -10.696558364013825 6.833567901118273 1.006624344736536 0.21524881765044138 0.9858008242070173 0.044397927581761455 0.004469975759921583 0.0001984871216610151 0.042884314617047156 0.014329369510857096 2.011136907155079e-11 10.696558364013825 -0.7913755270860946 ILLTLGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILLTLGIR 8 0 Q8N163;Q8N163-2;H0YB24;G3V119;A0A087X2B6 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 0 3417820.0 1000600.0 1681200.0 736020.0 False True 1311796.289824183 1430371.5132662742 659863.7108023762 1.0 1.090391491698748 0.5030230043498721 20.3231122690983 -6.867632170959303 1.1466220102047227 1.0504534649351671 0.47014772240847325 0.9622583667568079 0.05016745464679887 0.13914142950213687 0.34339684625503775 0.034003292028550076 0.08018522958677841 1.3563376866137477e-07 6.867632170959303 -0.5803057425266939 ILLTLGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILLTLGIR 8 0 Q8N163;Q8N163-2;H0YB24;G3V119;A0A087X2B6 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 0 13598400.0 7276000.0 4329300.0 1993100.0 False True 7045027.362681044 6058012.067001243 1471047.3182816633 1.0 0.8598990117613703 0.20880647335368815 22.74817387925548 -6.94144943183532 0.6459394871307564 1.0071647038830793 0.025479278720221488 0.9983476393567101 0.014012932550446637 0.08711160031495618 0.051645025724175175 0.0137952695023898 0.05569013524112511 1.1443281147674122e-07 6.94144943183532 -0.9816854251628578 down ILLTLGIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILLTLGIR 8 0 Q8N163;Q8N163-2;H0YB24;G3V119;A0A087X2B6 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 0 397402000.0 80482000.0 149370000.0 167550000.0 False True 122097078.02233349 122713756.46686336 134433669.0602262 1.0 1.0050507223802447 1.1010391996083326 26.86345343384575 -6.917792885980388 0.8409320228628201 0.997708950498992 1.1157588657703141 0.99354556359958 0.003734627518843793 0.09948796031919008 0.11247138334936177 0.003180708559688302 0.009335693498976824 1.2083899760605576e-07 6.917792885980388 0.11804991527132214 ILLTLGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILLTLGIR 8 0 Q8N163;Q8N163-2;H0YB24;G3V119;A0A087X2B6 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 0 12315400.0 1000600.0 3613100.0 7701700.0 False True 1370548.8601982663 3453461.2950760745 5882717.081490474 1.0 2.519765179751775 4.292234485269987 20.38632233062119 -6.969101644543163 0.27880889162002803 0.6038743139084916 6.262048554794815 0.9999745030359143 0.006793369757615158 0.07659527372048797 0.010069204457951826 0.032965914666972296 0.16293642200443478 1.073738079676584e-07 6.969101644543163 5.658174240886323 ILLTLGIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILLTLGIR 8 0 Q8N163;Q8N163-2;H0YB24;G3V119;A0A087X2B6 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 0 20471000.0 7276000.0 6678500.0 6516500.0 False True 6050316.381453008 6642521.594921544 7879070.021108279 1.0 1.0978800406676115 1.3022575224762194 22.528579154689755 -6.959193582121649 0.44665428165789345 0.9931791550796403 1.4150154688952017 0.9997391077718625 0.0020339261348652177 0.07999046105050929 0.022205308996178865 0.002718497839367767 0.016914168889813494 1.0985160784915882e-07 6.959193582121649 0.4218363138155614 ILLTLGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILLTLGIR 8 0 Q8N163;Q8N163-2;H0YB24;G3V119;A0A087X2B6 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 0 312852000.0 80482000.0 127060000.0 105310000.0 False True 104185535.53739753 119988999.30528362 86144660.57184906 1.0 1.1516857756345018 0.826838966920963 26.634579755938198 -6.779728496323827 1.5368195520005918 1.0859203478662982 0.8242834822297455 0.7664340892314966 0.06413924086379012 0.2510135828704642 1.1709544947906645 0.03287111159302368 0.0775831742752069 1.6606247396874173e-07 6.779728496323827 -0.26163686563655275 ILMEHIHK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILMEHIHKLK 10 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 4623100.0 764800.0 2254800.0 1603500.0 True False 635965.0863847255 2242652.9448572416 1938784.4362536813 1.0 3.526377458243917 3.048570554832028 19.278588040131655 -10.156249823401447 5.002599857328299 0.999862465655937 3.287474006542372 0.9683138190044708 0.19506385150499228 68268751.98258361 28.80413150312168 108154.6300756509 0.0667755447621359 6.978308686210042e-11 10.156249823401447 2.2876115408864353 ILMVGLDAAGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ILMVGLDAAGK 11 0 P84077;P61204;F5H423;F5H0C7;P61204-2;F5H1V1;F5H6T5;F8WDB3;P18085;C9JPM4;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 104900100.0 31858900.0 44787300.0 28253900.0 False True 41767326.422026455 38105209.419528 25330457.4585463 1.0 0.9123210098368375 0.606465858087292 25.315871461982486 -6.948020492659366 0.5801678396165462 1.0036537150758018 0.5000006800245655 0.9990366518333346 0.005235743770973248 0.08429046693578235 0.03932790228215669 0.005484695799400667 0.025551013387505497 1.1271442693875203e-07 6.948020492659366 -0.5036530350512363 ILMVGLDAAGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ILMVGLDAAGK 11 0 P84077;P61204;F5H423;F5H0C7;P61204-2;F5H1V1;F5H6T5;F8WDB3;P18085;C9JPM4;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 99527400.0 38684300.0 19252400.0 41590700.0 False True 37456288.07121527 26939983.719939675 30696847.97574487 1.0 0.7192379466090967 0.8195379082246819 25.158704599388034 -10.949671273825603 10.874365241129887 1.0654017077144629 0.7693879274168893 0.87575439046181 0.040947287863153735 0.022696731874032868 0.00010504486009294548 0.013859709821788503 0.013215680330529637 1.1228680539968095e-11 10.949671273825603 -0.2960137802975735 ILMVGLDAAGK ddPTM_RPMI8226_Bortezomib_8h_R1 2 ILMVGLDAAGK 11 0 P84077;P61204;F5H423;F5H0C7;P61204-2;F5H1V1;F5H6T5;F8WDB3;P18085;C9JPM4;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 181272900.0 36128000.0 107075000.0 38069900.0 False True 54808817.31058948 87966629.66920646 30545367.57837004 1.0 1.6049722286601984 0.5573075478946422 25.707904668108885 -6.750128589409497 1.6492830057458399 1.3556787637188012 0.5551971663163793 0.6495283782114071 0.25421599294359126 0.2998371011010123 1.604712753881069 0.12175736818277945 0.2955640225595913 1.777752960684374e-07 6.750128589409497 -0.800481597402422 ILMVGLDAAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ILMVGLDAAGK 11 0 P84077;P61204;F5H423;F5H0C7;P61204-2;F5H1V1;F5H6T5;F8WDB3;P18085;C9JPM4;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 119619800.0 31858900.0 34351100.0 53409800.0 False True 43637996.28439991 32833354.818102907 40795505.249359235 1.0 0.7524028968727068 0.9348620175748804 25.379081523505377 -10.30232006639389 4.914012729571287 1.0000583090355928 0.8436324574397244 0.49476227210160173 0.07448862410651218 4.760232798068894e-05 6.758437373041869e-06 0.07215016289215913 0.024041100053824576 4.9851695496559834e-11 10.30232006639389 -0.15642585159586841 ILMVGLDAAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ILMVGLDAAGK 11 0 P84077;P61204;F5H423;F5H0C7;P61204-2;F5H1V1;F5H6T5;F8WDB3;P18085;C9JPM4;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 83565100.0 38684300.0 22302700.0 22578100.0 False True 32167709.455063585 22182550.928360637 27299076.320660587 1.0 0.6895906268784343 0.8486484360596395 24.93910987482231 -10.271817224022271 5.099173631805209 1.0000446946683303 0.7691195314689686 0.7374868112627632 0.06493507868339982 3.3000561695111134e-05 4.71262496577937e-06 0.06288527301959926 0.020957706527087748 5.347893820266457e-11 10.271817224022271 -0.23092516319936174 ILMVGLDAAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ILMVGLDAAGK 11 0 P84077;P61204;F5H423;F5H0C7;P61204-2;F5H1V1;F5H6T5;F8WDB3;P18085;C9JPM4;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 122545600.0 36128000.0 53384000.0 33033600.0 False True 46768408.189347886 50413133.471692525 27021823.753358983 1.0 1.0779313520269602 0.5777794199015214 25.479030990201334 -6.8670881074274694 1.1493172848034483 1.0433911267328166 0.5500557912146141 0.9616933822405352 0.043003942408912525 0.1396813121047111 0.34666038440581226 0.02908574305114666 0.0685379551263162 1.3580379069026647e-07 6.8670881074274694 -0.4933353355182025 ILNAHMDSLQWIDQNSALLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILNAHMDSLQWIDQNSALLQR 21 0 P37198;M0QXN5 P37198 NUP62 Nuclear pore glycoprotein p62 0 8974600.0 4015000.0 2048800.0 2910800.0 False True 3338650.3946583006 2037762.7077450387 3519434.8219814245 1.0 0.6103552234775383 1.0541489542038818 21.670833599442943 -6.6747761767575255 1.920171500159524 0.7523271304610079 1.0524096681542927 0.3005273845089018 0.16533136427622674 0.45022050156554505 3.204605332546121 0.06920211191328741 0.18376503421900828 2.114578553768655e-07 6.6747761767575255 0.30008253769328486 ILNDDTALK(ub)EYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILNDDTALKEYK 12 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 22438000.0 12200000.0 10238000.0 0.0 True False 15994318.144968051 8710530.307411425 0.0 1.0 0.5446015409010625 0.0 23.93105615433057 -7.797502396240144 0.6216776219424631 1.0043506746743627 3.0088343124622e-19 0.9880431766447442 0.04469999514405908 0.11696589115069313 0.15561887791954984 0.0433824025228404 0.07786036488375904 1.594034085530229e-08 7.797502396240144 -1.0043506746743627 down ILNDDTALK(ub)EYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILNDDTALKEYK 12 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 40538000.0 16951000.0 13239000.0 10348000.0 True False 16412899.783508306 18525401.740472954 7637548.366654286 1.0 1.1287098553472732 0.4653381466648874 23.968326816756075 -6.856398425168607 1.2038748985785492 1.0692663756278875 0.43536759267641506 0.9490979737610379 0.06480254108673907 0.15056252214677984 0.4167251045692124 0.04204136222590786 0.09776804900124628 1.3918792960395884e-07 6.856398425168607 -0.6338987829514724 down ILNDDTALK(ub)EYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILNDDTALKEYK 12 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 96739400.0 37929300.0 41199100.0 17611000.0 True False 57541521.10325893 33846798.71496248 14130178.130824499 1.0 0.5882152238246189 0.24556490443601117 25.77810002326445 -7.800165729743569 0.2922293678878442 1.1151597437073246 1.550067660702152e-10 0.9994615182193021 0.007157124950107486 0.11913026923242323 0.045671054901592456 0.0428595639511555 0.083143963306034 1.5842885017673317e-08 7.800165729743569 -1.115159743552318 down ILNDDTALK(ub)EYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILNDDTALKEYK 12 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 36534000.0 12200000.0 14121000.0 10213000.0 True False 16710669.692603284 13497087.528097525 7800899.743337471 1.0 0.8076927960626138 0.46682149110938487 23.99426621585346 -6.962335566590358 0.4011639106964312 1.0184992661652297 0.24354509277582556 0.9998472508781204 0.0027247937857693217 0.07887714356431652 0.018124437165206193 0.004385468792482302 0.02854713179301741 1.090597338279745e-07 6.962335566590358 -0.7749541733894041 down ILNDDTALK(ub)EYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILNDDTALKEYK 12 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 37803800.0 16951000.0 14379000.0 6473800.0 True False 14095507.556625893 14301537.472991956 7827441.648530773 1.0 1.0146167078793282 0.5553146360346078 23.74873209219035 -6.89955051429439 0.9641194711353588 1.0193323296895989 0.5075432665018603 0.9863409404930032 0.024911895644475032 0.1117364029780864 0.17929797746656836 0.01939597109991209 0.050351375776405395 1.2602290477668804e-07 6.89955051429439 -0.5117890631877385 ILNDDTALK(ub)EYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILNDDTALKEYK 12 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 89910400.0 37929300.0 38565100.0 13416000.0 True False 49100226.54827918 36418918.28355256 10974425.659784714 1.0 0.7417260742726437 0.22351069294952847 25.5492263453569 -7.096124831028614 0.47586436537698223 1.0132401769590298 1.3844645893359547e-11 0.9995959050861484 0.006490307291230124 0.07610471146589158 0.026954102066573813 0.00804079340232326 0.04055692048327527 8.014476669160778e-08 7.096124831028614 -1.013240176945185 down ILNFLMHPK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ILNFLMHPK 9 0 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2 H0Y993 DEK Protein DEK 0 74211500.0 17070500.0 29617700.0 27523300.0 False True 22379590.81095717 25198854.60889039 24675452.938136224 1.0 1.1259747696795641 1.1025873147803482 24.415680322491898 -10.057596212017682 4.31207841174986 0.999990312877847 1.1142810422493636 0.9695457929913776 0.00954788854405801 1026787.7160801813 2397488.419041852 49.26253788047279 0.0032684963107276767 8.757976751131642e-11 10.057596212017682 0.11429072937151663 ILNFLMHPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILNFLMHPK 9 0 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2 H0Y993 DEK Protein DEK 0 50860200.0 22929300.0 10317000.0 17613900.0 False True 22201421.922364283 14436631.902444264 13000291.1843266 1.0 0.6502570850158804 0.5855611964759313 24.404148743248612 -13.999999999999998 0.2373155736449803 3.2852186250796342 0.5562178265159772 0.9995206096145858 0.0039858801178927926 13.530074904056315 0.15419732985305712 14.629897628819892 0.0321190623083016 1.0000000000000041e-14 13.999999999999998 -2.729000798563657 ILNFLMHPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILNFLMHPK 9 0 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2 H0Y993 DEK Protein DEK 0 41914200.0 21458200.0 10469000.0 9987000.0 False True 32553658.20455297 8600725.15532967 8013065.072542408 1.0 0.2642014946918245 0.24614945030729898 24.956316339000843 ILNFLMHPK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ILNFLMHPK 9 0 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2 H0Y993 DEK Protein DEK 0 75934500.0 17070500.0 22038800.0 36825200.0 False True 23381925.162916783 21065052.943434313 28127846.198800635 1.0 0.9009118281176873 1.2029739212154684 24.47889038401479 -6.818342172545975 1.3791302005587882 0.9465016903519076 1.2093316269063215 0.8805092697422005 0.043459506356102545 0.1956428292546424 0.7316413247321599 0.02476659626521184 0.05710707581430818 1.5193499904319591e-07 6.818342172545975 0.2628299365544139 ILNFLMHPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILNFLMHPK 9 0 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2 H0Y993 DEK Protein DEK 0 50541900.0 22929300.0 12021800.0 15590800.0 False True 19066728.890221346 11957036.177259522 18850764.196285587 1.0 0.6271152354503695 0.9886732173526357 24.18455401868289 -10.742038314323304 9.785587943928936 1.0005744254267437 0.8078942267281151 0.273473442566726 0.1476054280151645 0.0018550221086917208 4.8900950155244735e-05 0.14332173227282932 0.04763944704271248 1.81118029964136e-11 10.742038314323304 -0.19268019869862862 ILNFLMHPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILNFLMHPK 9 0 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2 H0Y993 DEK Protein DEK 0 42756800.0 21458200.0 15219300.0 6079300.0 False True 27778062.90435849 14372332.576160073 4972929.778885596 1.0 0.5173986618737549 0.17902363444159827 24.727442661093292 -8.181936607169249 0.3119260524683254 1.1309336802760726 7.775072485241497e-24 0.9988589484423103 0.011379680797738483 0.09191362937984551 0.07066219276393569 0.07514788861216647 0.09265756547888457 6.577538409580663e-09 8.181936607169249 -1.1309336802760726 down ILNFLMHPKPSGKPLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILNFLMHPKPSGKPLPK 17 2 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0 H0Y993 DEK Protein DEK 0 19050200.0 6302400.0 3269900.0 9477900.0 False True 8262507.432528418 2782043.6659703683 8497217.826436564 1.0 0.336706948670064 1.0284066787019304 22.97814823371964 -9.202484516051166 13.102233774677817 0.999997596508697 0.6825543308824026 0.21925312731628566 0.28238523231051105 0.0 0.0 0.2734183254967035 0.09113944183223446 6.273580628511883e-10 9.202484516051166 -0.31744326562629444 ILNFLMHPKPSGKPLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILNFLMHPKPSGKPLPK 17 2 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0 H0Y993 DEK Protein DEK 0 22594000.0 6302400.0 12429000.0 3862600.0 False True 8632567.595955983 11879845.6827933 2950333.4327440844 1.0 1.376165961139828 0.34176777649863976 23.04135829524253 -6.808295417449027 1.4216129816062646 1.2054206673851533 0.3243533939163832 0.8553626552350864 0.16258067612795574 0.20912430059716486 0.8332843828772116 0.08993203666318353 0.20820366173790014 1.554907586622657e-07 6.808295417449027 -0.8810672734687701 down ILNFLMHPKPSGKPLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILNFLMHPKPSGKPLPK 17 2 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0 H0Y993 DEK Protein DEK 0 49225300.0 4968300.0 15015000.0 29242000.0 False True 6431562.289834396 14179402.050754206 23920256.04825764 1.0 2.2046590566596698 3.7191983798501864 22.616737794284262 -6.968025024165635 0.3016570775457421 0.7424475794407253 5.228978596817686 0.9999626177998333 0.006801982904182633 0.07694892659764124 0.01131195855639112 0.0249224524152033 0.13559564914967656 1.0764031891997163e-07 6.968025024165635 4.486531017376961 ILNGVCVIWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILNGVCVIWK 10 0 J3KS23 J3KS23 CBFB 0 14316900.0 2658000.0 5077900.0 6581000.0 False True 3640734.429749143 4853541.587630235 5026703.339949462 1.0 1.3331215668934846 1.3806838803938293 21.795798077792025 -12.338418506509946 0.3031987102960835 0.0006838121594252866 1.3927590672873336 0.9995300865532482 0.0036713450387913507 6.352363496696592 0.16841703239973954 3.9569860686934906 0.016950451839086958 4.587557212584267e-13 12.338418506509946 1.3920752551279083 ILNIFGVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILNIFGVIK 9 0 P02786;G3V0E5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 0 14231800.0 2781300.0 5718200.0 5732300.0 False True 3646311.2341475147 4865066.849369027 5139176.584104322 1.0 1.334243441373827 1.4094179717782183 21.798006278478937 -12.499980100687159 0.23325263902609067 1.929661874865569e-09 1.447228392486086 0.9994152123765176 0.004303229512676578 6.644560044507164 0.14380392059948022 3.158133018826259 0.03820195818155304 3.162422558611143e-13 12.499980100687159 1.447228390556424 ILNIFGVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILNIFGVIK 9 0 P02786;G3V0E5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 0 6577600.0 3217600.0 1582500.0 1777500.0 False True 3115459.0492251916 2214400.502628479 1311919.4261430197 1.0 0.7107782409077712 0.42109987819268285 21.57101332302198 -6.9711056773061255 0.23025098314035983 1.1174416199178934 0.00615701724359525 0.9999897685973826 0.0007559324382005618 0.07594550661029491 0.007734235035195279 0.007429419921168079 0.028756801171516706 1.0687947766875841e-07 6.9711056773061255 -1.1112846026742982 down ILNIFGVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILNIFGVIK 9 0 P02786;G3V0E5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 0 25573300.0 4647900.0 8526400.0 12399000.0 False True 7051204.107005329 7004797.302932734 9948332.215325246 1.0 0.9934185986721771 1.410869982538392 22.749438211356576 -6.903320174691314 0.9400461035096668 0.9841890217535724 1.4577659040130426 0.9881466024390629 0.021258134133111912 0.10900272264639162 0.16396066693955227 0.016848795705795453 0.04461466379053829 1.2493376420927653e-07 6.903320174691314 0.47357688225947026 ILNIFGVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILNIFGVIK 9 0 P02786;G3V0E5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 0 18427300.0 2781300.0 5615000.0 10031000.0 False True 3809621.771806357 5366910.733678045 7661884.394929805 1.0 1.4087778407286058 2.0111929356432863 21.86121634000183 -6.965549530401362 0.3484919092300676 0.9407643516102342 2.49948711052426 0.9999240294843472 0.003620083198510526 0.07777496595831603 0.014205164950811137 0.008301338154472586 0.05183144545362979 1.0825562447512193e-07 6.965549530401362 1.558722758914026 up ILNIFGVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILNIFGVIK 9 0 P02786;G3V0E5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 0 7483500.0 3217600.0 1752800.0 2513100.0 False True 2675576.963848704 1743357.3184964405 3038577.5907384646 1.0 0.6515818240521457 1.1356719062073248 21.351418598456256 -6.713584940707661 1.782649902426916 0.7865867973806014 1.1346480703669777 0.4820218811860755 0.14674205564310303 0.3679082886143774 2.2812518262041257 0.06545670033077926 0.16555798770974098 1.9338155997727138e-07 6.713584940707661 0.34806127298637624 ILNIFGVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILNIFGVIK 9 0 P02786;G3V0E5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 0 19981900.0 4647900.0 7294600.0 8039400.0 False True 6016798.173806182 6888649.097531246 6576311.691209981 1.0 1.1449028035410298 1.0929919038733278 22.520564533449026 -10.290865910162486 4.209740656865977 0.9998769492754339 1.1189473537104742 0.8750083412251717 0.021192536056815568 2.4500352301822625e-05 4.1270954568066755e-06 0.02054078336033983 0.0068398615994675685 5.1183984336707665e-11 10.290865910162486 0.11907040443504024 ILNLSGNELK(ub)SER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILNLSGNELKSER 13 1 E9PIN3;Q9UBU9;Q9UBU9-2;B4E227 E9PIN3 NXF1 Nuclear RNA export factor 1 1 8173100.0 1816100.0 1450600.0 4906400.0 True False 1758448.8995828822 2029832.144779064 3621266.6511550588 1.0 1.1543310387128998 2.059352792119266 20.745871980267186 -6.936321881395684 0.6929403426136451 0.988911868886727 2.279081467250142 0.9976413141058194 0.022693804299579158 0.08948540440092395 0.0625564451137733 0.021517576641391596 0.07923745245695728 1.1579188357265277e-07 6.936321881395684 1.290169598363415 up ILNLSGNELK(ub)SER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILNLSGNELKSER 13 1 E9PIN3;Q9UBU9;Q9UBU9-2;B4E227 E9PIN3 NXF1 Nuclear RNA export factor 1 1 30204300.0 2202700.0 3841600.0 24160000.0 True False 2851438.5717082787 3627811.582962201 19763127.902534172 1.0 1.2722741492511978 6.930932371688515 21.4432585225135 -6.916923820189355 0.8472201807185625 0.8607735828053849 7.781882850279431 0.9932830364685749 0.224066837195451 0.10001593758536773 0.11524028582337988 0.18997519596229573 0.5533629058397121 1.210810503795443e-07 6.916923820189355 6.921109267474046 up ILNPEEIEK(ub)YVAEIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILNPEEIEKYVAEIEK 16 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 30557300.0 9943900.0 7704400.0 12909000.0 True False 9628236.337515663 10780807.09791523 9527745.63830112 1.0 1.1197073607248988 0.9895629172683486 23.198840124387218 -6.66486527285593 1.9554636228935733 1.0767425128005004 0.9900976567039695 0.25656457101524155 0.05090983137458444 0.4730091566247102 3.4818403784956793 0.02099621332956295 0.05647721062191308 2.1633895478880915e-07 6.66486527285593 -0.08664485609653083 ILNPEEIEK(ub)YVAEIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILNPEEIEKYVAEIEK 16 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 47767000.0 10091000.0 25305000.0 12371000.0 True False 15308784.750917802 20789125.04113256 9925866.427598068 1.0 1.357986631818453 0.648377163118907 23.867856426904854 -6.7695561235836115 1.576223742504613 1.205447615083049 0.6444591240214382 0.7288416163582687 0.15085548866568563 0.2671441985378325 1.3098088920917543 0.07544283788400759 0.179653301036013 1.699980252142846e-07 6.7695561235836115 -0.5609884910616109 ILNPEEIEK(ub)YVAEIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILNPEEIEKYVAEIEK 16 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 29174100.0 9943900.0 12437000.0 6793200.0 True False 8268793.439462687 12369999.412448797 8213626.711792025 1.0 1.495986022992565 0.9933283219523443 22.979245399821494 -10.406091878637154 3.7426535691463316 0.998536151057484 1.2446571724923137 0.24004717171702394 0.2052091472381173 25089641.40726937 34884505.32645094 246827.75243183068 0.07024854656395464 3.925618768592182e-11 10.406091878637154 0.24612102143482972 ILNREVVNYVQK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILNREVVNYVQK 12 1 Q9H9A7 Q9H9A7 RMI1 RecQ-mediated genome instability protein 1 1 580080000.0 76815000.0 88445000.0 414820000.0 True False 63875075.98148875 87968529.23004203 501556944.0890252 1.0 1.3771964710544635 7.852154167838147 25.92874976639568 -6.918863123849677 0.833112620157426 0.8511953914917014 8.869483615891909 0.9938592785571323 0.2464510680758624 0.09884546655196594 0.10911379085913259 0.2110740870485254 0.6255586890405368 1.2054157901792828e-07 6.918863123849677 8.018288224400207 up ILNVDEFVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILNVDEFVKR 10 1 Q9NVH2-3;Q9NVH2-2;Q9NVH2 Q9NVH2-3 INTS7 Integrator complex subunit 7 1 5968500.0 1540000.0 1574900.0 2853600.0 True False 1491113.542953383 2203765.782995003 2106156.553835006 1.0 1.4779329135661265 1.412472285419281 20.507958687186257 -10.588958093408914 6.264916136150212 0.998815830125042 1.4452025994926474 0.9840441183116225 0.02672418953364033 0.00044306021656717717 2.9069277878469952e-05 0.02593681951170271 0.008625195083723286 2.5765697672217947e-11 10.588958093408914 0.44638676936760535 ILNVDEFVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILNVDEFVKR 10 1 Q9NVH2-3;Q9NVH2-2;Q9NVH2 Q9NVH2-3 INTS7 Integrator complex subunit 7 1 16802200.0 3491900.0 6329400.0 6980900.0 True False 5297467.592085014 5199869.118172083 5601122.055162839 1.0 0.9815763905646627 1.0573206834774256 22.33687142608278 -6.842419045433177 1.2710051511059186 0.9901994447481777 1.0599352534322044 0.9285421454279348 0.008621734417020974 0.1659998372436121 0.5198473386611216 0.0053165950382717785 0.012258266530836705 1.4374109686588927e-07 6.842419045433177 0.06973580868402673 ILNVDEFVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILNVDEFVKR 10 1 Q9NVH2-3;Q9NVH2-2;Q9NVH2 Q9NVH2-3 INTS7 Integrator complex subunit 7 1 14361900.0 3491900.0 5714500.0 5155500.0 True False 4520333.3856395 5396483.051550786 4217251.89989714 1.0 1.1938241256042526 0.9329515193049236 22.10799774817523 -6.707697386343675 1.8030529390361294 1.1194327039394008 0.9335944225611011 0.45437946204509183 0.08170579813353589 0.3796935246529249 2.4046806359464146 0.03607848209139156 0.09192548770814568 1.9602100597630192e-07 6.707697386343675 -0.1858382813782996 ILPEYLSNWTMEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILPEYLSNWTMEK 13 0 O95831-3;O95831;E9PMA0;O95831-2 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 0 4448500.0 1012900.0 1893200.0 1542400.0 False True 1327921.708937552 1610741.939635801 1382807.24374553 1.0 1.2129795972117428 1.0413319056677603 20.340738660694925 -12.4527939281496 9.335167354897582 1.015338444836571 1.1144376972778471 0.0 0.09686924067658577 0.0 0.0 0.0 0.026512017262569267 3.525381099799025e-13 12.4527939281496 0.09909925244127615 ILPEYLSNWTMEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILPEYLSNWTMEK 13 0 O95831-3;O95831;E9PMA0;O95831-2 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 0 5029000.0 1012900.0 1840300.0 2175800.0 False True 1387396.5025932675 1758989.4609417093 1661920.852007604 1.0 1.2678347232776461 1.1978701466388348 20.403948722217816 -10.083138850460719 4.317237060932799 0.9999751598528483 1.232852434982344 0.9365834492541381 0.028562918906002557 4198723.292636858 4903172.050901115 804.4994108126132 0.009777846603459879 8.257738950666418e-11 10.083138850460719 0.23287727512949563 ILPGLYIGNFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILPGLYIGNFK 11 0 Q9NRW4;Q9NRW4-2;S4R459 Q9NRW4 DUSP22 Dual specificity protein phosphatase 22 0 19242400.0 3726000.0 9071500.0 6444900.0 False True 4884822.082635329 7718067.560430044 5778043.571846187 1.0 1.5800099634880045 1.1828565041060761 22.219874585934598 -10.339973600050541 5.12165360530532 0.9998411482737161 1.3814332337970867 0.5515432998794595 0.16213722084464297 0.0002942155870393328 3.791561720085633e-05 0.15705351084976546 0.05232956301094816 4.571159759957356e-11 10.339973600050541 0.38159208552337065 ILPGLYIGNFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILPGLYIGNFK 11 0 Q9NRW4;Q9NRW4-2;S4R459 Q9NRW4 DUSP22 Dual specificity protein phosphatase 22 0 16530300.0 5733500.0 3353400.0 7443400.0 False True 5551493.18085923 4692430.107749983 5493750.242786483 1.0 0.8452554934101015 0.9895986654055818 22.404444433559423 -10.475461285959035 7.006438833336524 1.0000174457333466 0.9174270794105541 0.30378431061118727 0.058927853207286184 1.606206507302571e-05 1.202510543130301e-06 0.05706869861261943 0.019018882841631238 3.3460984443964307e-11 10.475461285959035 -0.08259036632279249 ILPGLYIGNFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILPGLYIGNFK 11 0 Q9NRW4;Q9NRW4-2;S4R459 Q9NRW4 DUSP22 Dual specificity protein phosphatase 22 0 21995600.0 3726000.0 7263600.0 11006000.0 False True 5103602.891363926 6942670.134486889 8406609.475685129 1.0 1.3603468534424856 1.647191142145952 22.28308464745749 -6.973701852505252 0.14459068472687067 0.6401505940837446 2.374897430438012 0.9999987611966457 0.0002946499654207199 0.07511879131856768 0.0043970989704839435 0.015461679137311663 0.036605285237800926 1.0624246720348616e-07 6.973701852505252 1.7347468363542675 ILPGLYIGNFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILPGLYIGNFK 11 0 Q9NRW4;Q9NRW4-2;S4R459 Q9NRW4 DUSP22 Dual specificity protein phosphatase 22 0 12780700.0 5733500.0 2526600.0 4520600.0 False True 4767659.287116661 2512988.7043091636 5465836.559107207 1.0 0.5270906650355346 1.1464402613410705 22.1848497089937 -6.70264952161396 1.82142887009395 0.7071000733442203 1.1446889837028131 0.4300777746053075 0.199527161626953 0.39007902426828245 2.5177672090661987 0.08733172921532793 0.22386186208341918 1.9831267760300758e-07 6.70264952161396 0.4375889103585928 ILPGLYIGNFK(ub)DAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILPGLYIGNFKDAR 14 1 Q9NRW4;Q9NRW4-2;S4R459 Q9NRW4 DUSP22 Dual specificity protein phosphatase 22 1 17197800.0 5120400.0 9297000.0 2780400.0 True False 6712893.986024128 7909923.839422163 2492710.87948008 1.0 1.1783180035153518 0.37133178099784764 22.678503428027863 -6.848753722276896 1.2410647629984648 1.0950656669268986 0.3398343142196481 0.938476889378744 0.08585333656730253 0.15883200348379273 0.47139337959550776 0.054147772637812674 0.12520743937055231 1.416596869485568e-07 6.848753722276896 -0.7552313527072505 down ILPGLYIGNFK(ub)DAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILPGLYIGNFKDAR 14 1 Q9NRW4;Q9NRW4-2;S4R459 Q9NRW4 DUSP22 Dual specificity protein phosphatase 22 1 49167600.0 13132000.0 9625600.0 26410000.0 True False 19922204.077797286 7907836.474843941 21190051.924085766 1.0 0.39693582316311044 1.0636399387004303 24.247873931908863 -6.6684889202804944 1.9428044694977387 0.6145676841034285 1.0609242076271783 0.27235785394315803 0.25625798144742334 0.46458377034276366 3.379270569266622 0.10624471479229217 0.28441200529715543 2.1454138489091392e-07 6.6684889202804944 0.44635652352374977 ILPGLYIGNFK(ub)DAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILPGLYIGNFKDAR 14 1 Q9NRW4;Q9NRW4-2;S4R459 Q9NRW4 DUSP22 Dual specificity protein phosphatase 22 1 16066800.0 5120400.0 7927600.0 3018800.0 True False 7013550.253607034 7577332.4189325115 2305821.614137585 1.0 1.0803847045988624 0.3287666774686204 22.741713489550754 -6.880443015576584 1.0773734781517457 1.0501127141383029 0.27505563564004637 0.9740389616836427 0.05429422604853788 0.1272361725755438 0.26994719544885504 0.03880612809214302 0.09394585486282712 1.3169126954547567e-07 6.880443015576584 -0.7750570784982564 down ILPGLYIGNFK(ub)DAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILPGLYIGNFKDAR 14 1 Q9NRW4;Q9NRW4-2;S4R459 Q9NRW4 DUSP22 Dual specificity protein phosphatase 22 1 30760900.0 13931000.0 11476000.0 5353900.0 True False 11584243.747941433 11414176.510192346 6473375.736363327 1.0 0.9853190901840866 0.5588086609031921 23.46566052829283 -6.914206214828317 0.8665917618985753 1.0115145588494256 0.49842519497898946 0.9924145863036131 0.017820104506949107 0.10170209620614391 0.12416300784197984 0.014900033888214826 0.042434810700406514 1.2184109269148866e-07 6.914206214828317 -0.5130893638704361 ILPGLYIGNFK(ub)DAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILPGLYIGNFKDAR 14 1 Q9NRW4;Q9NRW4-2;S4R459 Q9NRW4 DUSP22 Dual specificity protein phosphatase 22 1 40219000.0 13132000.0 12010000.0 15077000.0 True False 16999632.870419502 11341632.942361519 12333140.703083938 1.0 0.6671692870554116 0.7254945325639607 24.019000254001313 -10.616537310469822 6.511756412048953 1.0009669043872116 0.6963319098096896 0.9730770072328542 0.023811181769750285 0.0003352383842115014 1.9741439428080603e-05 0.023123622835679064 0.007685025870646704 2.4180355942834636e-11 10.616537310469822 -0.30463499457752197 ILPQYIFNSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILPQYIFNSR 10 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 28154300.0 7414700.0 9389600.0 11350000.0 False True 9720743.504056934 7988708.280374134 10175610.876887813 1.0 0.8218207050767322 1.046793475482718 23.21263523383355 -6.695642636992328 1.8464951657901485 0.8888871355339338 1.0460700341080456 0.3968678537598844 0.07527355027384644 0.404667720748024 2.679252954907657 0.03256098306046482 0.08418890603550794 2.0153819423796147e-07 6.695642636992328 0.15718289857411172 ILPQYIFNSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILPQYIFNSR 10 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 28611300.0 9278700.0 4147600.0 15185000.0 False True 8984152.747403588 5803758.309448267 11207592.959764717 1.0 0.6459995141028237 1.2474846849641665 23.098951025785787 -6.747236530047287 1.6603216540076369 0.7911529387571129 1.2484150611130496 0.6369040796448882 0.14873669450073201 0.3048836274341212 1.6527712185636767 0.07079710817573939 0.17236109840229125 1.7896309008833502e-07 6.747236530047287 0.45726212235593666 ILPQYIFNSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILPQYIFNSR 10 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 22664100.0 7414700.0 5982100.0 9267300.0 False True 10156114.964733243 5717791.041840686 7078554.606034594 1.0 0.5629899879723218 0.6969746434157775 23.27584529535644 -10.744978102306527 10.299491087010837 1.0008742320390622 0.6299823156940515 0.9104655909964422 0.054699006533180515 0.0011001764325746666 2.7241032826206108e-05 0.0530644101514859 0.017654028446424892 1.7989616188301477e-11 10.744978102306527 -0.37089191634501073 ILPQYIFNSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILPQYIFNSR 10 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 17926300.0 9278700.0 4315800.0 4331800.0 False True 7715650.166106096 4292549.928780774 5237559.352019767 1.0 0.5563432551202774 0.6788228132773207 22.879356301220064 -10.339769580543509 8.550219509678945 1.000000865809084 0.6175830341988046 0.9285626403091224 0.050002070234382245 8.252353040128347e-07 6.378818330807863e-08 0.048414405966674505 0.016138098774471327 4.5733076685542527e-11 10.339769580543509 -0.3824178316102794 ILPTLEAVAALGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILPTLEAVAALGNK 14 0 Q12905;B4DY09;X6R6Z1 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 58567000.0 13292000.0 18923000.0 26352000.0 False True 17425940.719911087 16099762.161276279 23625347.82623331 1.0 0.9238963003518369 1.3557573852663636 24.05473320468499 -6.861385643006892 1.178602184906293 0.9585429169791164 1.3772416659209512 0.9553095085623524 0.03979107801715111 0.14538745667337746 0.382957247358976 0.026315452624566558 0.06153175154521289 1.37598708296539e-07 6.861385643006892 0.4186987489418348 ILPTLEAVAALGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILPTLEAVAALGNK 14 0 Q12905;B4DY09;X6R6Z1 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 54777000.0 20245000.0 14137000.0 20395000.0 False True 19602333.556552734 19781977.823481083 15052937.663115 1.0 1.009164432714609 0.7679155963593454 24.224522074167812 -6.898070400775077 0.9734023495436623 1.010568174259294 0.7435632401151179 0.9855811197744454 0.013404189088675059 0.11283902808410443 0.18554574942144883 0.010364409396262033 0.026714138077500848 1.2645313455508008e-07 6.898070400775077 -0.26700493414417614 ILPTLEAVAALGNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILPTLEAVAALGNK 14 0 Q12905;B4DY09;X6R6Z1 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 122103000.0 23111000.0 69215000.0 29777000.0 False True 35061076.64041835 56863042.47073674 23891562.89827728 1.0 1.6218281901014164 0.6814269608234199 25.063366962646228 -6.728414018953137 1.729235848874656 1.374875767382949 0.682168233553674 0.5518176955191081 0.2614354150534354 0.3392093591053811 1.9864588517739463 0.11985063441138995 0.29791139167251796 1.868899642910341e-07 6.728414018953137 -0.6927075338292751 ILPTLEAVAALGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILPTLEAVAALGNK 14 0 Q12905;B4DY09;X6R6Z1 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 76263000.0 13292000.0 27532000.0 35439000.0 False True 18206411.60279367 26315545.20385111 27069038.089115508 1.0 1.4453998831825343 1.4867860114159956 24.11794326620788 -11.807767025476673 0.38296052048166307 1.4035703853510118e-08 1.4906826857875233 0.9996690865537485 0.004008697586707566 4.856289548297365 0.19583157280109467 3.9411091688910314 0.01110983098255424 1.5568005434318233e-12 11.807767025476673 1.4906826717518193 ILPTLEAVAALGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILPTLEAVAALGNK 14 0 Q12905;B4DY09;X6R6Z1 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 47101000.0 20245000.0 12324000.0 14532000.0 False True 16834614.50556846 12257608.165877527 17570574.01162363 1.0 0.7281193259176219 1.043717039425627 24.004927349602088 -6.678727997351993 1.906135978140007 0.8277861706122494 1.0425124936007455 0.31845060095285194 0.11526091585411002 0.4413436196386043 3.099135561862319 0.04853712484266715 0.12823511236747606 2.0954244286443987e-07 6.678727997351993 0.21472632298849614 ILPTLEAVAALGNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILPTLEAVAALGNK 14 0 Q12905;B4DY09;X6R6Z1 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 81413000.0 23111000.0 29946000.0 28356000.0 False True 29917645.08591728 28279478.775350347 23195498.95712995 1.0 0.9452441425164829 0.7753116560650841 24.834493284738677 -6.950686410694914 0.5512611890311503 1.0023327383691993 0.710222659918266 0.9992540200462608 0.0026127611644877562 0.08321137308173004 0.034831363316420276 0.002831255357307396 0.014100711156136257 1.1202464834643759e-07 6.950686410694914 -0.2921100784509333 ILPVFDEPPNPTNVEESLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILPVFDEPPNPTNVEESLKR 20 1 Q9NYL9;H0YNJ8;H0YKU1 Q9NYL9 TMOD3 Tropomodulin-3 1 17944400.0 3331800.0 4167600.0 10445000.0 True False 4313080.779596697 3935669.396385171 8544117.1747504 1.0 0.9124961013953427 1.9809777769915395 22.04028730585386 -6.887046586111172 1.0397230428300073 0.9384586267628304 2.067721537655735 0.97893858564202 0.0702960879401489 0.12157099817249616 0.2361213609670089 0.05170583273092033 0.12760314851553164 1.29704013199137e-07 6.887046586111172 1.1292629108929049 ILQAGFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILQAGFK 7 0 Q15691 Q15691 MAPRE1 Microtubule-associated protein RP/EB family member 1 0 10631400.0 2988200.0 3714700.0 3928500.0 False True 3917559.1377699594 3160481.2397871898 3522016.5048329337 1.0 0.8067475508707367 0.8990333983414516 21.901523622483673 -10.073383955989206 4.420988147636363 1.0000114966707956 0.8528904745946029 0.77210845860367 0.03767553950522322 52312641.33959983 0.9999760057337167 6272.246138195997 0.012897339277109243 8.445318717008767e-11 10.073383955989206 -0.1471210220761927 ILQAGFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILQAGFK 7 0 Q15691 Q15691 MAPRE1 Microtubule-associated protein RP/EB family member 1 0 7044940.0 3279100.0 842540.0 2923300.0 False True 3175006.765388596 1178970.615788055 2157600.03287983 1.0 0.3713285365688845 0.679557617451488 21.598328235345097 -10.534800204038511 6.411482312420284 1.0004939330082112 0.5254430770102596 0.7596494636802412 0.12583399534157066 0.0008893136194606903 6.452607436821766e-05 0.12195854379296645 0.04061274736205373 2.918769476912121e-11 10.534800204038511 -0.4750508559979516 ILQAGFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILQAGFK 7 0 Q15691 Q15691 MAPRE1 Microtubule-associated protein RP/EB family member 1 0 15886800.0 2416500.0 11204000.0 2266300.0 False True 3666007.169813983 9204558.662748454 1818364.8116454226 1.0 2.510785777654522 0.49600688908027646 21.80577817676361 -6.7060120327884105 1.809182512897527 1.93254527892968 0.5012265868579804 0.44624476323618356 0.6370477074066183 0.383153214427255 2.4420547016048073 0.280466893805352 0.7160482749519903 1.967831767182852e-07 6.7060120327884105 -1.4313186920716996 ILQAGFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILQAGFK 7 0 Q15691 Q15691 MAPRE1 Microtubule-associated protein RP/EB family member 1 0 8758100.0 2988200.0 2674200.0 3095700.0 False True 4093018.2930686157 2556045.0016031726 2364559.4179428015 1.0 0.6244890246231604 0.5777055582544307 21.964733684006564 -13.999999999999998 0.2937183300646204 4.304544664465285 0.5654278729145361 0.9996357859984623 0.0036071741512694808 16.190653510482342 0.1719510420763419 32.398300612873776 0.017377389860484253 1.0000000000000041e-14 13.999999999999998 -3.7391167915507495 ILQAGFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILQAGFK 7 0 Q15691 Q15691 MAPRE1 Microtubule-associated protein RP/EB family member 1 0 6410300.0 3279100.0 1747700.0 1383500.0 False True 2726716.938760661 1738284.7932087122 1672783.453418753 1.0 0.6375010066130268 0.6134789532569015 21.378733510779373 -13.999999999999998 0.3856720296952825 6.5755371360171075 0.6115747862210477 0.9998165007474973 0.0023952017163637435 24.768362524395407 0.2031074693070601 114.92340414455933 0.0064024825857469025 1.0000000000000041e-14 13.999999999999998 -5.96396234979606 ILQEHEQIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILQEHEQIKK 10 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 23107800.0 9146800.0 9152600.0 4808400.0 True False 8856439.84070519 12807280.910178479 3548935.7910920437 1.0 1.4460981094586993 0.4007181051217372 23.078295442329683 -6.790734792061968 1.4932336528496362 1.2490858967790224 0.3893470563288522 0.8037523091288995 0.1897359025590038 0.23425243969574977 1.0318257552424546 0.10000650550752285 0.23403141762117602 1.6190684423806188e-07 6.790734792061968 -0.8597388404501702 down ILQEHEQIK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILQEHEQIKK 10 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 23755600.0 12864000.0 7633300.0 3258300.0 True False 19515628.484372884 6271077.97575488 2614295.576836377 1.0 0.3213362039955023 0.1339590768972555 24.218126588514814 -13.507617776888267 0.18935180812150307 3.983338387330831 3.193938215523307e-21 0.9994649590654774 0.008605629668206253 10.248661443943249 0.13616546962677153 11.369359521449804 0.1285005445043762 3.107293117584153e-14 13.507617776888267 -3.983338387330831 ILQEHEQIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILQEHEQIKK 10 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 27382300.0 9146800.0 14948000.0 3287500.0 True False 7605969.471945351 14867472.157054292 3974901.05031742 1.0 1.9547109953429374 0.5226028141420839 22.85870071776396 -6.727002840749568 1.73411801018662 1.5764383700116913 0.5238966024015792 0.5453792598911122 0.40143954387495645 0.34186193027878836 2.0125889468677203 0.18355563372144482 0.4570415469486851 1.8749822436416863e-07 6.727002840749568 -1.052541767610112 ILQEHEQIK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILQEHEQIKK 10 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 21601800.0 12864000.0 7351800.0 1386000.0 True False 16652701.587349746 6942665.86724841 1133762.2215609418 1.0 0.41690928230662694 0.06808278017917563 23.989252910607263 -8.426929666404217 0.4077471851289773 1.0878043818421046 9.860919377203283e-16 0.9966906011030656 0.02211580172007969 0.16295693734698227 0.12155319300896412 0.08638861464177029 0.07927402038682911 3.7417118004733835e-09 8.426929666404217 -1.0878043818421037 ILQIITELIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILQIITELIK 10 0 Q7Z478;A0A087WYN9 Q7Z478 DHX29 ATP-dependent RNA helicase DHX29 0 18288600.0 4522200.0 8320300.0 5446100.0 False True 6860508.017104396 6835477.458199391 4369675.947889578 1.0 0.9963515006698339 0.6369318331813393 22.709883980506604 -6.909120365545645 0.9017057117007349 1.0114402968928111 0.5913465624786494 0.9905853289380255 0.016523933836999204 0.10500253255405698 0.1419443126453548 0.013469802251410378 0.036959923585879566 1.2327631232227557e-07 6.909120365545645 -0.42009373441416176 ILQIITELIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILQIITELIK 10 0 Q7Z478;A0A087WYN9 Q7Z478 DHX29 ATP-dependent RNA helicase DHX29 0 12327300.0 4522200.0 4209200.0 3595900.0 False True 5854077.045888754 3974954.3198158317 2941483.097049777 1.0 0.6790061505267331 0.5024674383326649 22.481010302599053 -12.061322114097836 0.08849637777838847 2.2409973699524026 2.198224973470327e-11 0.9999009027796985 0.002050182465293363 5.824153567139339 0.06619305050289413 1.7353365244958292 0.3741595660332481 8.683161645300444e-13 12.061322114097836 -2.24099736993042 ILQLCMGNHELYMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILQLCMGNHELYMR 14 0 P15311;E7EQR4 P15311 EZR Ezrin 0 62184400.0 43372000.0 14742000.0 4070400.0 False True 41995179.60063255 20628557.47851442 3004240.1306174663 1.0 0.49121250759465035 0.07153773740670501 25.323720402451166 -8.03200387618985 0.45731892517688627 1.0414169072378496 9.594823219403027e-19 0.99563274540006 0.025087572228463632 0.1003054803787516 0.11106340437012407 0.04563964585916313 0.07925377421928129 9.289580955532239e-09 8.03200387618985 -1.0414169072378496 ILQLCMGNHELYMR ddPTM_RPMI8226_Bortezomib_8h_R1 3 ILQLCMGNHELYMR 14 0 P15311;E7EQR4 P15311 EZR Ezrin 0 1318816200.0 469936200.0 404202000.0 444678000.0 False True 712927572.3381486 332068995.05535966 356787198.3907085 1.0 0.46578223081805015 0.5004536396601601 29.40918027709188 -9.974975376485913 5.682464730710595 1.000000773971891 0.4831179352387477 0.9966367566779438 0.014154543389028591 1.387895363808171e-07 2.5049493696255977e-08 0.013705098329111924 0.00456835923472255 1.0593137841684456e-10 9.974975376485913 -0.5168828387331433 ILQLCMGNHELYMR ddPTM_RPMI8226_Carfilzomib_1h_R1 3 ILQLCMGNHELYMR 14 0 P15311;E7EQR4 P15311 EZR Ezrin 0 67530300.0 12119400.0 22870200.0 32540700.0 False True 16600269.694470182 21859718.942362167 24855256.8567533 1.0 1.316829144627933 1.4972803041286122 23.98470334456169 -10.956059321808056 0.09341548548031825 6.059483104629184e-18 2.0101549535829712 0.9999143269106352 0.0019024915514174508 3.2800392102624927 0.05678397219089688 1.0367201700201416 0.32984418826864886 1.1064726366728529e-11 10.956059321808056 2.0101549535829712 ILQLCMGNHELYMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ILQLCMGNHELYMR 14 0 P15311;E7EQR4 P15311 EZR Ezrin 0 89932300.0 50399000.0 11300600.0 28232700.0 False True 41909001.554267414 11239721.424806524 34136027.036744215 1.0 0.26819349084831706 0.814527327560928 25.32075681512732 -10.094331785302764 7.004122563334212 1.0000002079985841 0.5413604092058962 0.4844427836852344 0.22303985486048714 7.244608675128311e-07 9.37270706555461e-08 0.21595750739183645 0.07198580361793212 8.04763396116451e-11 10.094331785302764 -0.4586397987926879 ILQLCMGNHELYMR ddPTM_RPMI8226_Carfilzomib_8h_R1 3 ILQLCMGNHELYMR 14 0 P15311;E7EQR4 P15311 EZR Ezrin 0 1146530200.0 469936200.0 389280000.0 287314000.0 False True 608341674.7273866 367616225.795378 235025800.09059224 1.0 0.6042923591583894 0.3863384835436653 29.18030659918433 -9.898580322827188 0.13549620231164206 1.708684179185858 9.564982263061653e-11 0.9998170083989809 0.0034360382404786884 1.4338932631400578 0.06084507215347723 0.57593768347558 0.21312863005461885 1.263047481389566e-10 9.898580322827188 -1.708684179090208 ILQLK(ub)ESR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILQLKESR 8 1 Q13435;E9PPJ0;E9PJ04;H0YCG1 Q13435 SF3B2 Splicing factor 3B subunit 2 1 44431900.0 16165800.0 21206300.0 7059800.0 True False 21193520.349829905 18042402.70150998 6329319.618383484 1.0 0.8513169310097548 0.2986440909253796 24.337119910695197 -6.946562309630683 0.5954008283912265 1.0062934418411027 0.11559918535743051 0.9989030539393176 0.009993867982341862 0.08489647027745305 0.04190854890338529 0.010304196760163685 0.04637684216688953 1.1309351187824956e-07 6.946562309630683 -0.8906942564836722 down ILQLK(ub)ESR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILQLKESR 8 1 Q13435;E9PPJ0;E9PJ04;H0YCG1 Q13435 SF3B2 Splicing factor 3B subunit 2 1 67799700.0 26201100.0 25420600.0 16178000.0 True False 25369360.422257017 35571178.14667771 11940496.470403247 1.0 1.4021314512710557 0.470666042488309 24.596583812810508 -6.789400409681931 1.4989596965804686 1.2249257094333497 0.46095410191584957 0.7993085253514757 0.1708839430700129 0.23624520694496315 1.0486915015455043 0.08974022189328128 0.21017501653020434 1.6240507272727488e-07 6.789400409681931 -0.7639716075175 down ILQLK(ub)ESR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILQLKESR 8 1 Q13435;E9PPJ0;E9PJ04;H0YCG1 Q13435 SF3B2 Splicing factor 3B subunit 2 1 76767400.0 33429200.0 22769400.0 20568800.0 True False 50714540.401880994 18706022.671865806 16503367.664374681 1.0 0.3688492989117575 0.3254168830792081 25.595896106867787 -13.951946107440095 0.38035732779128545 9.99996332863011 0.32159288840274525 0.9998070986690102 0.004281591104597447 23.16834741138372 0.20097688361225458 170.50752289101956 0.011764711490290014 1.1170018504033027e-14 13.951946107440095 -9.678370440227365 ILQLK(ub)ESR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILQLKESR 8 1 Q13435;E9PPJ0;E9PJ04;H0YCG1 Q13435 SF3B2 Splicing factor 3B subunit 2 1 48588300.0 16165800.0 18933800.0 13488700.0 True False 22142733.124318566 18097242.110296253 10302946.86849663 1.0 0.8172993825419277 0.46529698075895043 24.40032997221809 -6.960768861693923 0.424458722044763 1.0148322159768093 0.254388121634362 0.9997976603427964 0.0031565650053721923 0.07942760833840193 0.02012488332504046 0.004567896655183376 0.029266693823681734 1.0945387418965809e-07 6.960768861693923 -0.7604440943424473 down ILQLK(ub)ESR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILQLKESR 8 1 Q13435;E9PPJ0;E9PJ04;H0YCG1 Q13435 SF3B2 Splicing factor 3B subunit 2 1 83213300.0 26201100.0 46127000.0 10885200.0 True False 21787375.555537138 45878504.69550738 13161244.992521742 1.0 2.105738003118398 0.6040766570977332 24.376989088244784 -6.709381973627444 1.7972261624123231 1.6802015470993423 0.6076378702142926 0.46225742768873734 0.4659960496096933 0.37631408748472084 2.3689917203063833 0.2063596599630824 0.5246794633651145 1.9526213175709516e-07 6.709381973627444 -1.0725636768850497 ILQLK(ub)ESR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILQLKESR 8 1 Q13435;E9PPJ0;E9PJ04;H0YCG1 Q13435 SF3B2 Splicing factor 3B subunit 2 1 73297700.0 33429200.0 25889500.0 13979000.0 True False 43274758.38804659 24448726.566300485 11434965.436652545 1.0 0.564965062244085 0.26424100012563273 25.367022428960237 -8.176800224038502 0.24456838689754154 1.2031882180408013 9.616327271081738e-14 0.9995529084706377 0.006386409203848217 0.08800774356198472 0.05155545015805005 0.08899892311894461 0.10348861958836524 6.655792530162929e-09 8.176800224038502 -1.2031882180407052 down ILQLVATGAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILQLVATGAVR 11 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQQ5;A0A1B0GTT3 P47897 QARS Glutamine--tRNA ligase 0 27072300.0 5129300.0 10354000.0 11589000.0 False True 7781523.102059521 8506247.803828768 9298429.070360865 1.0 1.093134042303034 1.1949368971094962 22.891621135425712 -6.969984187437585 0.2585729653763673 0.9709161710783522 1.3201694565249458 0.9999822508980363 0.0003353399950655809 0.07630794482873192 0.009048961318571976 0.002144908451884805 0.009625958655326172 1.0715583197198457e-07 6.969984187437585 0.3492532854465936 ILQVSFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILQVSFK 7 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 0 86192000.0 28430000.0 27791000.0 29971000.0 False True 37272005.31651165 23644691.128469523 26869888.4221326 1.0 0.6343820496826026 0.7209134092452258 25.15158910555785 -10.01192180162028 5.673935061523256 1.000000798066719 0.6776477294637734 0.9487270678753669 0.03532627961346029 3.566379035537078e-07 6.211745184148711e-08 0.03420460801560582 0.011401507718792944 9.729223908781653e-11 10.01192180162028 -0.32235306860294555 ILQVSFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILQVSFK 7 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 0 70113000.0 35709000.0 13522000.0 20882000.0 False True 34575437.34111839 18921405.116298456 15412377.753428172 1.0 0.5472499141405341 0.445760890928752 25.043244164202555 -13.999999999999996 0.21012453544290247 3.619755792177349 0.3860560247577944 0.9994900815883785 0.005440726419667346 12.749636571014022 0.14529094265858467 13.790320428345076 0.06006479551163897 1.0000000000000082e-14 13.999999999999996 -3.2336997674195547 ILQVSFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILQVSFK 7 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 0 121120000.0 34906000.0 50477000.0 35737000.0 False True 52954953.97042289 41468984.97139895 28673566.285916455 1.0 0.7830992544070714 0.5414708943365639 25.65826231980299 -6.969730198385164 0.2645503460187308 1.0641773045600085 0.2531811540764007 0.9999802005506843 0.0008333315406700689 0.0763903472915647 0.009342914640261444 0.004899638362329942 0.02264596532963829 1.072185183965541e-07 6.969730198385164 -0.8109961504836078 ILQVSFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILQVSFK 7 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 0 98607000.0 28430000.0 29801000.0 40376000.0 False True 38941339.29186163 28484293.2812715 30840020.36982215 1.0 0.7314667086251049 0.7919609579598466 25.21479916708074 -10.851451985487783 7.306778820266879 1.0195745300689714 0.7617138332924758 0.953890508091455 0.024696673873802973 0.00769034062709184 0.00015634569955962467 0.023351354755916168 0.007970817218329563 1.4078228651352219e-11 10.851451985487783 -0.2578606967764956 ILQVSFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILQVSFK 7 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 0 64652000.0 35709000.0 15489000.0 13454000.0 False True 29693615.676924884 15405557.682674205 16267169.195732478 1.0 0.5188171710138342 0.547833897115258 24.82364943963683 -10.738700931291174 6.873973697594859 1.007461928268484 0.5333255340647888 0.9971088363573725 0.011846028825764429 0.001357388005691136 5.1598082802285654e-05 0.011492878290633664 0.0038232893634065524 1.825152126272613e-11 10.738700931291174 -0.47413639420369524 ILQVSFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILQVSFK 7 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 0 139966000.0 34906000.0 64660000.0 40400000.0 False True 45186505.100126736 61061614.15929195 33047614.539005868 1.0 1.3513241182071567 0.7313602693055626 25.42938864189544 -6.752972501397059 1.6387874619203369 1.2058438254838446 0.7298399522943505 0.6616592328509587 0.14765617153115493 0.29490181142242383 1.5591069298852633 0.07114838999072567 0.17219729749530685 1.7661496459852126e-07 6.752972501397059 -0.4760038731894941 ILQVSFK(ub)TNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILQVSFKTNK 10 1 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 1 9367800.0 3219700.0 2937600.0 3210500.0 True False 3117492.385874677 4110598.9993816246 2369573.7370645115 1.0 1.3185594351430343 0.7600896630256496 21.571954605762677 -6.751949629144801 1.6423511741755408 1.1868692661609297 0.7587918427725626 0.6574716945901358 0.13387611903302132 0.2966354051593937 1.5747654662654764 0.06437401761480382 0.1559812264013868 1.7703142730901893e-07 6.751949629144801 -0.4280774233883671 ILRPGGCLFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILRPGGCLFLK 11 1 Q6FI81;H3BV90;Q6FI81-3;H3BT65;H3BUG4;H3BQ23;H3BPG7 Q6FI81 CIAPIN1 Anamorsin 0 113978000.0 36622000.0 29837000.0 47519000.0 False True 48011796.647952534 25385435.903715044 42602189.7144345 1.0 0.5287333046470697 0.8873275463281641 25.51688558826455 -9.775649845206985 6.108635327999329 1.0000000096878845 0.7080304254871418 0.4691886557075443 0.14639548613818826 1.933796947086424e-08 3.976372972267845e-09 0.14174682522301693 0.04724893998084637 1.676293862041333e-10 9.775649845206985 -0.2919695842007427 ILRPGGCLFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILRPGGCLFLK 11 1 Q6FI81;H3BV90;Q6FI81-3;H3BT65;H3BUG4;H3BQ23;H3BPG7 Q6FI81 CIAPIN1 Anamorsin 0 52214500.0 31637000.0 6446500.0 14131000.0 False True 30632700.752218276 9020621.068053389 10429667.17908695 1.0 0.2944768448926319 0.3404749474573078 24.868569232913483 -10.091297879569678 6.752591849689203 1.0000004989114386 0.3174758961749694 0.996605090096476 0.01877864673661248 1.4103634759909032e-07 1.8978475249265563e-08 0.018182359793657843 0.006060782172934057 8.104050160094654e-11 10.091297879569678 -0.6825246027364692 ILRPGGCLFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILRPGGCLFLK 11 1 Q6FI81;H3BV90;Q6FI81-3;H3BT65;H3BUG4;H3BQ23;H3BPG7 Q6FI81 CIAPIN1 Anamorsin 0 37178000.0 11177000.0 15515000.0 10486000.0 False True 16956326.14815262 12746227.030751724 8413437.503822934 1.0 0.751709239335457 0.49618280695429845 24.01532028564624 -6.970765779937168 0.2391971634627781 1.0926706830102584 0.14783804789376637 0.9999877521586389 0.0007198269381650204 0.0760550536101538 0.00813616838423061 0.006142910582627708 0.024946961018218628 1.0696315884459689e-07 6.970765779937168 -0.944832635116492 down ILRPGGCLFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILRPGGCLFLK 11 1 Q6FI81;H3BV90;Q6FI81-3;H3BT65;H3BUG4;H3BQ23;H3BPG7 Q6FI81 CIAPIN1 Anamorsin 0 89495000.0 36622000.0 22987000.0 29886000.0 False True 50162143.072337575 21971358.332156256 22827542.32149062 1.0 0.43800677137083055 0.45507510092963116 25.58009564978744 -9.873591926331224 6.895070297642169 1.0000000094715764 0.446540936181936 0.9992872078296448 0.006968116363481433 1.0182302429699528e-09 1.6038921120587245e-10 0.006746849808341312 0.0022489498858458763 1.3378520044561704e-10 9.873591926331224 -0.5534590732896404 ILRPGGCLFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILRPGGCLFLK 11 1 Q6FI81;H3BV90;Q6FI81-3;H3BT65;H3BUG4;H3BQ23;H3BPG7 Q6FI81 CIAPIN1 Anamorsin 0 56247000.0 31637000.0 6553000.0 18057000.0 False True 26307567.25673843 6517697.688331344 21832635.21386516 1.0 0.24774992019309192 0.8298994354285245 24.64897450834776 -10.253578148987003 7.599802349210418 1.0000009799581275 0.5388246778124862 0.4555635503947313 0.23766154438923193 3.945978129484044e-06 3.875764508022644e-07 0.23011529113947746 0.07670493362111917 5.577272330555749e-11 10.253578148987003 -0.4611763021456413 ILRPGGCLFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILRPGGCLFLK 11 1 Q6FI81;H3BV90;Q6FI81-3;H3BT65;H3BUG4;H3BQ23;H3BPG7 Q6FI81 CIAPIN1 Anamorsin 0 57090000.0 11177000.0 27779000.0 18134000.0 False True 14468846.831608187 26233074.230296493 14833798.07055277 1.0 1.813072910066927 1.0252232429572288 23.78644660773869 -10.233823135153106 3.9905719423259676 0.9996775504404853 1.4191480760193969 0.2739876447429044 0.3216382809838422 43691016.34016409 37348977.42865718 123202.94798942213 0.11010533840208828 5.836827585573177e-11 10.233823135153106 0.4194705255789115 ILRPGGCLFLK(ub)EPVETAVDNNSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILRPGGCLFLKEPVETAVDNNSK 23 2 Q6FI81;H3BV90;Q6FI81-3;H3BT65;H3BUG4;H3BQ23 Q6FI81 CIAPIN1 Anamorsin 1 29163200.0 8267300.0 9296900.0 11599000.0 True False 10838510.36064709 7909838.759032367 10398846.745464483 1.0 0.729790210631872 0.9594350514459113 23.369663151255196 -10.10674556683028 6.604572394051593 1.000000195817773 0.8446126313125099 0.37905916233358394 0.0937521136761783 2.702840571624421e-07 3.666031822686243e-08 0.09077520735716574 0.03025836457829849 7.820858585460055e-11 10.10674556683028 -0.15538756450526325 ILRPGGCLFLK(ub)EPVETAVDNNSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILRPGGCLFLKEPVETAVDNNSK 23 2 Q6FI81;H3BV90;Q6FI81-3;H3BT65;H3BUG4;H3BQ23 Q6FI81 CIAPIN1 Anamorsin 1 73679800.0 9161800.0 23652000.0 40866000.0 True False 11860130.706077492 22335745.408221032 33428807.320569623 1.0 1.883263006264806 2.8185867549874204 23.499616573587083 -6.970399830602959 0.24844990879880033 0.6974541869966107 4.031736142751633 0.9999853356340626 0.0028434687383791335 0.07617315330905916 0.008564625456713217 0.021082242156513664 0.08987071532903836 1.0705332713959615e-07 6.970399830602959 3.3342819557550225 ILRPWQSSETR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILRPWQSSETR 11 1 Q15637-6;Q15637-2;Q15637-4;Q15637-3;Q15637;Q15637-5;Q15637-7 Q15637-6 SF1 Splicing factor 1 0 9755900.0 1735300.0 4911000.0 3109600.0 False True 2274995.104669106 4178297.942928064 2787848.4213894564 1.0 1.836618432432095 1.2254305144076096 21.117432010249924 -10.134591691538551 5.001698591990861 0.9999750774897753 1.5310244734211664 0.5016223319955764 0.24951642269022922 6.934919524210611e-05 1.1999515241493466e-05 0.2416045575416524 0.08053107913972239 7.335138330760662e-11 10.134591691538551 0.5310493959313911 ILRPWQSSETR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILRPWQSSETR 11 1 Q15637-6;Q15637-2;Q15637-4;Q15637-3;Q15637;Q15637-5;Q15637-7 Q15637-6 SF1 Splicing factor 1 0 9196700.0 1735300.0 3359300.0 4102100.0 False True 2376887.3047192227 3210875.018280438 3133268.4654014134 1.0 1.3508738979359112 1.318223400487025 21.180642071772816 -10.070109973571277 4.509064726577604 0.9999794144079652 1.3345486492319671 0.9929069836917732 0.013329509839011629 9251031.892938584 0.07839885461797297 2060.716892227183 0.004563045751135188 8.509225373304782e-11 10.070109973571277 0.3345692348240019 ILSEVTPDQSK(ub)PEN ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILSEVTPDQSKPEN 14 1 O43482 O43482 OIP5 Protein Mis18-beta 1 9841400.0 3619400.0 3507800.0 2714200.0 True False 4745068.45031946 2984449.913297303 2433360.6204448384 1.0 0.6289582425510376 0.5128188657175248 22.177997468419694 -13.999999999999998 0.1626086076662773 2.8377636038191723 0.4018716490178774 0.9995297507839315 0.004505481195085925 12.028080368755804 0.12751541450898093 6.970759633661592 0.10145981996494752 1.0000000000000041e-14 13.999999999999998 -2.4358919548012947 ILSEVTPDQSK(ub)PEN ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILSEVTPDQSKPEN 14 1 O43482 O43482 OIP5 Protein Mis18-beta 1 10346700.0 3938300.0 4113700.0 2294700.0 True False 3813280.822216427 5756321.8626621 1693649.230475606 1.0 1.5095457510302905 0.4441449002675841 21.862601348985294 -6.776644945620131 1.5488729492569877 1.2897741887820064 0.4365661036012176 0.755363749957077 0.21519616707908773 0.25582189658422044 1.2119452313462071 0.10945551258315696 0.2590102574771873 1.6724573612259495e-07 6.776644945620131 -0.8532080851807888 down ILSEVTPDQSK(ub)PEN ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILSEVTPDQSKPEN 14 1 O43482 O43482 OIP5 Protein Mis18-beta 1 28655500.0 18267000.0 5640500.0 4748000.0 True False 27712374.49658265 4633908.70557235 3809555.718877675 1.0 0.16721442278949356 0.1374676760141016 24.724026995661617 -13.097854914683806 0.48575484868256424 9.999999999013333 0.13858224890053125 0.9999186515249708 0.0036056994004393522 17.652224584061067 0.24315432377454718 167.21429997839627 0.00622777048843395 7.982613189141062e-14 13.097854914683806 -9.861417750112802 ILSEVTPDQSK(ub)PEN ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILSEVTPDQSKPEN 14 1 O43482 O43482 OIP5 Protein Mis18-beta 1 8685000.0 3619400.0 3078500.0 1987100.0 True False 4957589.990607244 2942481.6907618637 1517787.9056091157 1.0 0.5935306663795821 0.3061543831750405 22.241207529942585 -8.083088579235445 0.2228897875451311 1.2231780455686205 6.885093865224865e-17 0.9997235216963295 0.004733032459753739 0.09298915059524433 0.042720169501283045 0.082844564575578 0.10367952987514838 8.258694870438603e-09 8.083088579235445 -1.2231780455686205 down ILSEVTPDQSK(ub)PEN ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILSEVTPDQSKPEN 14 1 O43482 O43482 OIP5 Protein Mis18-beta 1 12362050.0 3938300.0 7456400.0 967350.0 True False 3274870.946272176 7416230.8932204805 1169618.4124789527 1.0 2.2645872203490836 0.35714946685466886 21.64300662441957 -6.727941655481734 1.7302849705245702 1.7627900944252326 0.35862774023622496 0.5497307254869932 0.5317018794715046 0.3401947146769477 1.9942934331376898 0.24358557314378634 0.6059586620510635 1.8709334707063094e-07 6.727941655481734 -1.4041623541890076 ILSEVTPDQSK(ub)PEN ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILSEVTPDQSKPEN 14 1 O43482 O43482 OIP5 Protein Mis18-beta 1 26053300.0 18267000.0 7786300.0 0.0 True False 23646991.596402176 7352985.560292213 0.0 1.0 0.31094803456567177 0.0 24.495153317754067 -8.693971418637993 0.49515062560513623 1.0710776729763138 7.692422182486139e-20 0.9946789754194231 0.030481123995673022 0.3170662364680368 0.1902768932708076 0.10740415897929004 0.06230332815293267 2.023152320011081e-09 8.693971418637993 -1.0710776729763138 ILSGVVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILSGVVTK 8 0 P62280;M0QZC5 P62280 RPS11 40S ribosomal protein S11 0 9923400.0 1895600.0 3821100.0 4206700.0 False True 2485149.9570165155 3251006.7745311414 3771431.03751577 1.0 1.3081732815970817 1.5175869073283075 21.2449014777382 -7.67385237369307 0.06807643244726233 2.934831711512078e-09 2.684466043144583 0.9999990115230345 0.0002112750667459446 0.14029990940705928 0.007676331712046606 0.1345677653990555 0.1624178641513409 2.1190813354845446e-08 7.67385237369307 2.684466040209751 ILSGVVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILSGVVTK 8 0 P62280;M0QZC5 P62280 RPS11 40S ribosomal protein S11 0 8138700.0 3516700.0 1168100.0 3453900.0 False True 3405064.283444253 1634528.421561027 2549219.975221031 1.0 0.48002865305899217 0.7486554622817494 21.699250604134445 -10.416525628419036 5.0253230023259885 1.0004508739033244 0.6143420576703381 0.7332035839515509 0.10966643563806608 0.0005546128969697921 6.439448072159357e-05 0.10630528554051336 0.03539468990533025 3.832431239368018e-11 10.416525628419036 -0.3861088162329863 ILSGVVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILSGVVTK 8 0 P62280;M0QZC5 P62280 RPS11 40S ribosomal protein S11 0 9247000.0 1895600.0 2905400.0 4446000.0 False True 2596454.54666384 2777029.8211270194 3395946.3682442373 1.0 1.069546865241758 1.3079167407754766 21.30811153926109 -6.948424865429668 0.5758848244382193 0.997104537333281 1.3920660021483966 0.9990717415174308 0.00401724077563737 0.08412465183089002 0.0386293095290639 0.0042279995094246774 0.019890497754064214 1.1260952707389838e-07 6.948424865429668 0.3949614648151156 ILSGVVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILSGVVTK 8 0 P62280;M0QZC5 P62280 RPS11 40S ribosomal protein S11 0 4893440.0 3516700.0 648470.0 728270.0 False True 2924291.866225365 644976.5633987838 880547.8898599752 1.0 0.2205582044829576 0.30111491264945933 21.47965587956872 -10.427535147250456 6.0088257144209845 1.0002684719708468 0.2608365586880326 0.9911705806406593 0.03288713839437144 0.00011832274693662576 1.1272660769940821e-05 0.031853957523414314 0.01061427827548481 3.736498848470376e-11 10.427535147250456 -0.7394319132828142 ILSIMYYAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILSIMYYAR 9 0 Q9UJA5;Q9UJA5-2;Q9UJA5-3 Q9UJA5 TRMT6 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 0 26380300.0 5652500.0 7885800.0 12842000.0 False True 8575255.75310304 6478517.377963377 10303773.071151447 1.0 0.7554896978575901 1.2015703516974319 23.031748268974773 -6.757899602418099 1.6205753469187119 0.8576029043971587 1.2030217829000496 0.6822567321752906 0.10281242665495288 0.28646081237221777 1.4822952712874298 0.050070017012652325 0.12056749161173427 1.7462257882212294e-07 6.757899602418099 0.3454188785028909 ILSIMYYAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILSIMYYAR 9 0 Q9UJA5;Q9UJA5-2;Q9UJA5-3 Q9UJA5 TRMT6 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 0 23292500.0 5652500.0 9587900.0 8052100.0 False True 7317272.6774327 9054324.936558539 6586700.421522993 1.0 1.237390669406527 0.900157847313402 22.802874591067223 -6.717540311711803 1.7680984298563631 1.1448053562662976 0.9007533633682082 0.5008695391083087 0.09992654037713938 0.3601423096693839 2.1989384727593344 0.044897578801233975 0.1130399762330989 1.9162831828776292e-07 6.717540311711803 -0.24405199289808943 ILSISADIETIGEILKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILSISADIETIGEILKK 17 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 940370000.0 248600000.0 369590000.0 322180000.0 False True 377144375.0944569 303633776.8801498 258500981.78348935 1.0 0.8050863195403718 0.6854165111669689 28.490541668163093 -12.662526313756132 0.05256522387703245 2.2227437947606217 2.6322701991304362e-11 0.9999801062057058 0.0005782284522084005 7.73863299022041 0.04558439627743966 1.6148752978282903 0.5592954527530006 2.1750722431336165e-13 12.662526313756132 -2.222743794734299 ILSISADIETIGEILKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILSISADIETIGEILKK 17 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 691610000.0 248600000.0 226100000.0 216910000.0 False True 321817600.63861495 213517336.2421267 177434605.68454853 1.0 0.6634731469578508 0.5513514653407621 28.261667990255543 -13.999999999999998 0.15356476843133515 2.636829693230546 0.4329116352025727 0.9995547798403489 0.004022635624268949 11.972878718256354 0.12358794276684808 5.842553442481322 0.10714249183656965 1.0000000000000041e-14 13.999999999999998 -2.2039180580279734 ILSK(ub)ALEHSSCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILSKALEHSSCK 12 1 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 22738400.0 5301700.0 9858700.0 7578000.0 True False 6950580.041735835 8387820.388911623 6793901.253308881 1.0 1.2067799145604619 0.9774581707589651 22.72870194837146 -6.669115990412228 1.9401490361513307 1.132082087023074 0.9783805897928479 0.27533217628886975 0.08785258679951172 0.4631232212187311 3.3599205547858073 0.03646203958078411 0.09754256136039258 2.1423183590452324e-07 6.669115990412228 -0.15370149723022597 ILSK(ub)ALEHSSCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILSKALEHSSCK 12 1 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 12773790.0 4820200.0 3800200.0 4153390.0 True False 4667185.38944408 5317639.677781204 3065492.55997084 1.0 1.1393675704008408 0.6568182542960819 22.154121344344148 -6.8294484185389175 1.3302959158696472 1.0744992195467764 0.6439720132159674 0.9047792048322865 0.06257132648522809 0.18149447051752274 0.6283438605928164 0.036931835635984074 0.08499591425293773 1.480988142825555e-07 6.8294484185389175 -0.430527206330809 ILSK(ub)ALEHSSCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILSKALEHSSCK 12 1 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 50355600.0 6749400.0 12176000.0 31430200.0 True False 10239333.247234616 10003097.668477787 25218007.193653964 1.0 0.9769286170248799 2.4628563779252626 23.287618438902374 -6.903374084771708 0.9396858286507647 0.9438088113264013 2.6299759848609185 0.9881716087732003 0.07559784975636082 0.10896427742645538 0.16374183851246674 0.05993306679039544 0.15874930675717727 1.249182568253646e-07 6.903374084771708 1.6861671735345172 up ILSK(ub)ALEHSSCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILSKALEHSSCK 12 1 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 20040000.0 5301700.0 6566500.0 8171800.0 True False 7261881.763055321 6276370.3174883155 6241789.143503882 1.0 0.8642897973661903 0.8595277845556313 22.79191200989435 ILSK(ub)ALEHSSCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILSKALEHSSCK 12 1 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 18427600.0 4820200.0 4543500.0 9063900.0 True False 4008209.8710664865 4519023.263685866 10959119.583261458 1.0 1.1274417780133517 2.7341681039135572 21.934526619778424 -6.922694012005364 0.8044981541987036 0.9678721625832908 3.0100289900419894 0.9948970717423419 0.05637442046414959 0.09661234871083799 0.09759095823628805 0.049278636160349255 0.15163784295773233 1.1948296412000227e-07 6.922694012005364 2.0421568274586988 up ILSK(ub)ALEHSSCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILSKALEHSSCK 12 1 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 33642100.0 6749400.0 10121000.0 16771700.0 True False 8737231.350564225 9557757.452925969 13719422.692174347 1.0 1.093911454262769 1.5702254114272007 23.058744760994824 -6.939487397038466 0.6643192226645791 0.9946034782150206 1.69675642844063 0.9980959385954266 0.010892888311637091 0.0880013160956998 0.05568128687992614 0.010562654366156287 0.041088857701875384 1.1495096010048031e-07 6.939487397038466 0.7021529502256094 ILSK(ub)LHTVQPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILSKLHTVQPK 11 1 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 1 301545000.0 20245000.0 65200000.0 216100000.0 True False 26541391.052858893 55472414.147609375 193740044.97757325 1.0 2.0900341672797964 7.299543742516263 24.66174064955678 -6.940817510316762 0.6519131870617205 0.9422491175380561 8.738827997459802 0.998269037586256 0.11437035565164658 0.08739563367215072 0.05292594546714578 0.11203308652279396 0.4467816077929532 1.145994384863985e-07 6.940817510316762 7.796578879921746 ILSK(ub)LHTVQPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILSKLHTVQPK 11 1 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 1 802914000.0 59234000.0 119790000.0 623890000.0 True False 57353649.093052305 167622771.6965973 460474492.7011919 1.0 2.922617380886106 8.028686927210229 25.773381944017945 -6.954153765752604 0.511215651961044 0.9069585204563011 10.268820465356626 0.9994882143972498 0.06709735685857642 0.0818594897658438 0.029382371392874532 0.07712183030537698 0.4214510135194765 1.1113381786321753e-07 6.954153765752604 9.361861944900324 ILSK(ub)LHTVQPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILSKLHTVQPK 11 1 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 1 380430000.0 54600000.0 157440000.0 168390000.0 True False 82832191.79467954 129343601.91566555 135107642.69204104 1.0 1.561513695499888 1.6311006598369313 26.30368822803046 -11.548525091434126 0.3515637919935472 2.0239179402520817e-12 1.641845599299782 0.9995301555940818 0.006124169655966644 4.0368080465645235 0.18118602011112447 3.0713564169214833 0.020624243119958325 2.8279707198605634e-12 11.548525091434126 1.641845599297758 ILSK(ub)LHTVQPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILSKLHTVQPK 11 1 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 1 230193000.0 20245000.0 44968000.0 164980000.0 True False 27730123.60055359 42981165.07070962 126015121.86975579 1.0 1.5499810130616067 4.544340432266955 24.72495071107967 -6.937924534405181 0.6785953485468923 0.9648774213005206 5.304801937750996 0.9978792511810269 0.07172331269644257 0.08872632925503991 0.05901750311561016 0.06876472544211881 0.26016298826043543 1.1536537061414864e-07 6.937924534405181 4.339924516450476 up ILSK(ub)LHTVQPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILSKLHTVQPK 11 1 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 1 447594000.0 59234000.0 267410000.0 120950000.0 True False 49255695.51113072 265969409.2532711 146240085.79038537 1.0 5.399769640714296 2.9689984939373817 25.55378721945222 -9.845637893907435 8.304418657368448 0.9999999991762499 4.184384067325839 0.695885897725197 0.9923581651805599 1.454220775069474e-08 0.0 0.9608466689631792 0.3202822206014379 1.426796732502339e-10 9.845637893907435 3.1843840681495887 ILSK(ub)LHTVQPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILSKLHTVQPK 11 1 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 1 306862000.0 54600000.0 166830000.0 85432000.0 True False 70680776.32690412 157545763.84464374 69884252.6063453 1.0 2.2289761379527335 0.988730688003838 26.07481455012291 -6.648261172201099 2.0144364196349387 1.7985824669779236 0.9939149181501165 0.1870610863440908 0.5247667839050145 0.5128691680440378 3.987069259111225 0.21139899516612876 0.5813094849655548 2.247702495731268e-07 6.648261172201099 -0.8046675488278071 ILSKPIEVQVGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILSKPIEVQVGGR 13 1 A0A0C4DG89;Q7L014 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 18795200.0 8422100.0 4957200.0 5415900.0 False True 11041454.659732413 4217605.08301426 4855514.620981215 1.0 0.38197911534207873 0.4397531639276674 23.396426917136832 -10.397500300194935 5.171180137407259 1.0004514186566371 0.4108661396348454 0.9928389332089258 0.023586156568339022 0.0001228423095031215 1.4312505929266673e-05 0.022854028056519014 0.007612399299170966 4.0040519156061976e-11 10.397500300194935 -0.5895852790217917 ILSKPIEVQVGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILSKPIEVQVGGR 13 1 A0A0C4DG89;Q7L014 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 14399200.0 4217700.0 3688900.0 6492600.0 False True 4083811.4221522594 5161897.007359366 4791993.286175067 1.0 1.2639900509017459 1.1734119896382433 21.9614848178594 -10.083656231733423 4.403757482480778 0.9999807744219823 1.2187010202265323 0.8860152162781691 0.036978338727844486 4116290.001491831 9425417.784051612 440.53758395166864 0.012658670081155812 8.247907244783348e-11 10.083656231733423 0.21872024580454996 ILSKPIEVQVGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILSKPIEVQVGGR 13 1 A0A0C4DG89;Q7L014 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 21571400.0 4084900.0 10117000.0 7369500.0 False True 6197091.946192067 8311542.305518218 5912915.094833401 1.0 1.3412004174999241 0.954143515405918 22.56315994304458 -6.673969415346249 1.923462807708316 1.2170386641899094 0.9556824412679759 0.2967284735366257 0.14480307379398336 0.45203570216331135 3.227947267662074 0.06052822371354297 0.16087439319241784 2.1185103234743448e-07 6.673969415346249 -0.2613562229219335 ILSKPIEVQVGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILSKPIEVQVGGR 13 1 A0A0C4DG89;Q7L014 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 20730800.0 8422100.0 6030600.0 6278100.0 False True 11535977.968694603 5764148.151472626 4795342.081528144 1.0 0.49966705615379137 0.4156857870690593 23.459636978659724 -13.999999999999998 0.25110954972710714 4.499133311243035 0.38227285322070553 0.9995447848210074 0.005503399451991762 14.042188365460042 0.15856576021550936 24.80104064176166 0.03851910371976366 1.0000000000000041e-14 13.999999999999998 -4.11686045802233 ILSKPIEVQVGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILSKPIEVQVGGR 13 1 A0A0C4DG89;Q7L014 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 9777800.0 4217700.0 2981900.0 2578200.0 False True 3507204.425790868 2965835.91283919 3117289.699750074 1.0 0.8456410156845647 0.888824636746725 21.741890093293677 -10.38380711172267 5.777191522672494 1.0000365785410976 0.8672328262156446 0.9264880687502467 0.01762963947466709 8.308202793473165e-06 8.861621656231305e-07 0.01707452372202936 0.005689941673752078 4.132309943435926e-11 10.38380711172267 -0.13280375232545305 ILSLICNSSSEKPTVQQLQILWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILSLICNSSSEKPTVQQLQILWK 23 1 Q9Y263;E5RIM3;H0YC16 Q9Y263 PLAA Phospholipase A-2-activating protein 0 38381000.0 10732000.0 14037000.0 13612000.0 False True 16281228.614294885 11531987.678418415 10921582.23364845 1.0 0.7082995977523068 0.6708082352003413 23.956706236596403 -13.999999999999998 0.28924281907438676 3.5028822319586466 0.6605135483042144 0.9996257667947878 0.0028465087845475946 15.920940448649056 0.17053557911082862 23.700470822755925 0.014208215564945725 1.0000000000000041e-14 13.999999999999998 -2.842368683654432 ILSLICNSSSEKPTVQQLQILWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILSLICNSSSEKPTVQQLQILWK 23 1 Q9Y263;E5RIM3;H0YC16 Q9Y263 PLAA Phospholipase A-2-activating protein 0 26933200.0 10732000.0 9671400.0 6529800.0 False True 13892785.559346793 9133178.088156141 5341443.401405952 1.0 0.6574043807947153 0.3844760561939527 23.727832558688853 -7.578912510857215 0.20380412258058045 1.2004839308087567 2.131292989747988e-13 0.9999311413896856 0.002089642923364816 0.1319365016454606 0.021620267664075023 0.03756899221946847 0.07258535924541318 2.6368625314342045e-08 7.578912510857215 -1.2004839308085435 down ILSLSWHPSGTHIAAGSIDYISVFDVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILSLSWHPSGTHIAAGSIDYISVFDVK 27 0 Q969X6;H3BSH7;Q969X6-3;Q969X6-2;J3KTR0;J3KSI1 Q969X6 CIRH1A Cirhin 0 74898000.0 20453000.0 28077000.0 26368000.0 False True 31028696.314589422 23066439.983397733 21156353.242495045 1.0 0.7433905617411356 0.6818318445608529 24.887099746834277 -13.999999999999998 0.20052719747909778 2.4293247884645126 0.6420598341340953 0.9994869582650641 0.0031209427664729227 12.541366597686116 0.1419887618469862 7.032317677221916 0.039043831925386574 1.0000000000000041e-14 13.999999999999998 -1.7872649543304173 ILSLSWHPSGTHIAAGSIDYISVFDVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILSLSWHPSGTHIAAGSIDYISVFDVK 27 0 Q969X6;H3BSH7;Q969X6-3;Q969X6-2;J3KTR0;J3KSI1 Q969X6 CIRH1A Cirhin 0 57606000.0 20453000.0 21107000.0 16046000.0 False True 26476811.68890424 19932376.895455822 13125792.645863567 1.0 0.752823909829331 0.4957467235892399 24.658226068926727 -6.970631408377325 0.2426342657374649 1.0893455232410703 0.15176520215664335 0.9999868957042384 0.0007452377035392171 0.07609836853117312 0.00829378123531259 0.006032213329255278 0.02494641682153522 1.0699625857488414e-07 6.970631408377325 -0.9375803210844269 down ILSYK(ub)IGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILSYKIGK 8 1 P52907;P47755 P52907;P47755 CAPZA1;CAPZA2 F-actin-capping protein subunit alpha-1;F-actin-capping protein subunit alpha-2 1 4698200.0 1919600.0 1215300.0 1563300.0 True False 2484960.0409729877 1147667.4866654428 1278795.4408125712 1.0 0.46184544932001115 0.5146140862336998 21.244791222257163 -10.667375811292667 10.345049620637926 1.0001853793193283 0.48822976837257465 0.9920893206889041 0.021542705810121677 9.213932277892209e-05 2.9625495844401788e-06 0.02086578352387782 0.006952878402903918 2.1509196577811488e-11 10.667375811292667 -0.5119556109467536 ILTFDQLALDSPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILTFDQLALDSPK 13 0 J3QQ67;Q07020;G3V203;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 42842600.0 9080600.0 17718000.0 16044000.0 False True 11904754.5366555 15074543.464223053 14383920.784915237 1.0 1.2662624347110703 1.2082500937441611 23.505034538293057 -10.038960301804375 4.414262211088057 0.9999869755038567 1.2372562642137512 0.9570842346984625 0.023683439124479806 8193044.168416358 0.12399941743050374 1130.9839854389627 0.008107471140157274 9.141968029852848e-11 10.038960301804375 0.2372692887098945 ILTFDQLALDSPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILTFDQLALDSPK 13 0 J3QQ67;Q07020;G3V203;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 44598600.0 9080600.0 18535000.0 16983000.0 False True 12437943.213988 17716062.41295147 12971965.175864112 1.0 1.4243562708203694 1.0429349091476425 23.568244599815948 -10.500932650012995 6.7315526368730865 0.99989789208264 1.2336455899840058 0.3334734903511839 0.15571461884928955 0.0002387232492534318 1.7698601519656658e-05 0.15083554237699084 0.05025667713036115 3.155493936516816e-11 10.500932650012995 0.23374769790136574 ILTFDQLALDSPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILTFDQLALDSPK 13 0 J3QQ67;Q07020;G3V203;Q07020-2;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 21845800.0 17085000.0 0.0 4760800.0 False True 14206934.49383241 0.0 5756261.268547886 1.0 0.0 0.4051726479802399 23.7600919543549 -10.714704147712933 6.705967456225363 1.009738654956174 0.20258632399012694 0.8377800828528517 0.1654110408806495 0.02383820354768716 0.0010141610062980586 0.1585246813800824 0.053386183884132465 1.9288384388295026e-11 10.714704147712933 -0.8071523309660471 ILTGGADK(ub)NVVVFDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILTGGADKNVVVFDK 15 1 Q9UMS4 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 1 15711800.0 6388100.0 5298800.0 4024900.0 True False 8269521.378276492 5003917.121980455 3292409.498961496 1.0 0.6051035958532531 0.39813785446041017 22.979372401118663 -10.84806384314 0.12116855816597244 1.9579530345353229 2.889881776371852e-17 0.9998162268543986 0.0033845955065339517 2.9740755406251314 0.06969658349549886 1.0638390110296563 0.2576311546376347 1.4188489295170805e-11 10.84806384314 -1.9579530345353229 ILTIEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILTIEVK 7 0 P25685;M0R080;P25685-2;M0QXK0;M0QYT3 P25685 DNAJB1 DnaJ homolog subfamily B member 1 0 26144000.0 7449800.0 7879200.0 10815000.0 False True 9766759.94396583 6703654.072881052 9695967.544805432 1.0 0.6863744078221921 0.9927517007107218 23.21944860664176 -10.776607324789062 9.614171420195065 1.0011417444588837 0.8395630543488425 0.267733865167065 0.12507800605868855 0.0030808263128650117 7.158514359845828e-05 0.12189053502023504 0.04036875287017759 1.67260224439567e-11 10.776607324789062 -0.16157869011004122 ILTIEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILTIEVK 7 0 P25685;M0R080;P25685-2;M0QXK0;M0QYT3 P25685 DNAJB1 DnaJ homolog subfamily B member 1 0 23253100.0 9291600.0 6168600.0 7792900.0 False True 8996643.24396471 8631754.148824027 5751705.70801123 1.0 0.9594416400377481 0.6393168598598921 23.100955384252913 -6.930347565281956 0.7439347057639595 1.0048059433282728 0.5730116616452474 0.9966060750017476 0.009398080498564209 0.09245787061499497 0.07679934308866417 0.008579850875326017 0.028910639682933906 1.1739576621752245e-07 6.930347565281956 -0.43179428168302536 ILTIEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILTIEVK 7 0 P25685;M0R080;P25685-2;M0QXK0;M0QYT3 P25685 DNAJB1 DnaJ homolog subfamily B member 1 0 158006000.0 20362000.0 78067000.0 59577000.0 False True 30890642.661598306 64135333.90974505 47801579.836473316 1.0 2.076205879312277 1.5474453011590412 24.880666549908593 -10.228254174215017 4.535423355386512 0.9997501748280189 1.8118255902415479 0.7586297259002988 0.21586560215720021 152169195.01878396 185.91603450363112 407779.61033622496 0.07389653729729481 5.912155194324775e-11 10.228254174215017 0.812075415413529 ILTIEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILTIEVK 7 0 P25685;M0R080;P25685-2;M0QXK0;M0QYT3 P25685 DNAJB1 DnaJ homolog subfamily B member 1 0 36579800.0 7449800.0 11963000.0 17167000.0 False True 10204192.383275092 11434435.10364924 13112508.16546308 1.0 1.1205624780644614 1.2850118532608996 23.28265866816465 -6.966788596667657 0.325904501416281 0.9789835545017085 1.4319414621318314 0.9999454018429581 0.0008631297037621816 0.07735919414285626 0.012747656777276531 0.0024358553388745302 0.014391982687967281 1.0794720534644836e-07 6.966788596667657 0.4529579076301229 ILTIEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILTIEVK 7 0 P25685;M0R080;P25685-2;M0QXK0;M0QYT3 P25685 DNAJB1 DnaJ homolog subfamily B member 1 0 18159000.0 9291600.0 4039400.0 4828000.0 False True 7726377.087673008 4017638.9504418797 5837512.477850193 1.0 0.519990016647232 0.7555303619808577 22.88136065968719 -10.17179394704271 5.131829569291448 1.0000190035648702 0.6377601893164773 0.759242412017107 0.09615894332196903 2.240106930734336e-05 3.6153648146014313e-06 0.09311072370178954 0.031035165505608225 6.732960288235054e-11 10.17179394704271 -0.3622588142483929 ILTIEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILTIEVK 7 0 P25685;M0R080;P25685-2;M0QXK0;M0QYT3 P25685 DNAJB1 DnaJ homolog subfamily B member 1 0 121154000.0 20362000.0 59936000.0 40856000.0 False True 26359010.395026077 56600508.91202168 33420627.217960943 1.0 2.147292635944411 1.2679014392842072 24.651792872001042 -10.140506312999431 4.509688062803736 0.9999236684685385 1.7075970374687917 0.4633090549047958 0.3590099528967889 250904189.553964 46.03474319612881 245243.45021419006 0.1228986559484628 7.235918839141585e-11 10.140506312999431 0.7076733690002531 ILTPIIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILTPIIFK 8 0 G5E9W7;G5E9V5;P82650;H7C5L9 G5E9W7 MRPS22 28S ribosomal protein S22, mitochondrial 0 2534300.0 706770.0 643730.0 1183800.0 False True 926582.3143704169 547687.9932398874 1061311.731811436 1.0 0.5910840135255807 1.145404693518852 19.821559620423802 -6.709076851500905 1.7985584598237891 0.7483673835572651 1.1440628335762857 0.4606598898568558 0.1723404585017538 0.3769486344705693 2.3763689856963364 0.07627142556944189 0.1939779073434928 1.9539936520902133e-07 6.709076851500905 0.3956954500190206 ILTPIIFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILTPIIFK 8 0 G5E9W7;G5E9V5;P82650;H7C5L9 G5E9W7 MRPS22 28S ribosomal protein S22, mitochondrial 0 1877270.0 706770.0 1170500.0 0.0 False True 968081.9687410854 1118783.439674114 0.0 1.0 1.155670155832986 0.0 19.884769681946693 -6.933688433172987 1.2333673911008232 1.0837640177014167 1.6901817936751035e-21 0.9656968211811224 0.09483838366244764 0.11508474687463328 0.349356710497037 0.06356148456121798 0.12252813442169243 1.1649614836994691e-07 6.933688433172987 -1.0837640177014167 down ILTPLVSLDTPGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILTPLVSLDTPGK 13 0 Q9HC38-2;F6TLX2;Q9HC38;I3L1I0 Q9HC38-2 GLOD4 Glyoxalase domain-containing protein 4 0 7024300.0 1222500.0 3357700.0 2444100.0 False True 1602709.3387068412 2856744.248212087 2191207.9774626866 1.0 1.7824468724423068 1.3671898731373713 20.612081376832556 -10.449884601583998 5.573151428498746 0.9995060859345406 1.5748183727897658 0.718694498773276 0.16952796006939874 0.0010412465682839574 0.00010277898148117915 0.1642791261238814 0.05471491383877399 3.549076808838564e-11 10.449884601583998 0.5753122868552252 ILTPLVSLDTPGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILTPLVSLDTPGK 13 0 Q9HC38-2;F6TLX2;Q9HC38;I3L1I0 Q9HC38-2 GLOD4 Glyoxalase domain-containing protein 4 0 5261660.0 2809700.0 810260.0 1641700.0 False True 2720507.611452026 1133801.0434500806 1211689.520055694 1.0 0.41676084223301735 0.4453909685659636 21.375444434108164 -10.699560894554523 6.736342326871635 1.0053850985462227 0.43107590539951673 0.9981042757738494 0.011688200131189737 0.0009476224293827226 4.226365244887653e-05 0.011344916577780539 0.003772350371269762 1.9972807003076438e-11 10.699560894554523 -0.5743091931467059 ILTPLVSLDTPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILTPLVSLDTPGK 13 0 Q9HC38-2;F6TLX2;Q9HC38;I3L1I0 Q9HC38-2 GLOD4 Glyoxalase domain-containing protein 4 0 7090700.0 1222500.0 2651000.0 3217200.0 False True 1674491.28682029 2533870.0543153137 2457363.6203138437 1.0 1.5132178197994137 1.4675284605273515 20.675291438355448 -10.106205997786232 5.172226852061413 0.9999883152001819 1.4903731401641158 0.9935312609922899 0.0186526028177654 2.513324164919042e-06 4.343289022734366e-07 0.018060734990785317 0.006020101672684546 7.830581287124077e-11 10.106205997786232 0.4903848249639339 ILTTIEDLDQKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILTTIEDLDQKK 12 1 O95347;O95347-2;A0A0C4DGE5 O95347 SMC2 Structural maintenance of chromosomes protein 2 1 32278000.0 6696600.0 4528400.0 21053000.0 True False 10159231.787037566 3720271.6394493137 16891865.32214231 1.0 0.3661961570948807 1.6627108895866605 23.27628797784392 -6.77378398289172 1.5599237146670775 0.6382163380607931 1.6710733286969186 0.7447956640234747 0.2674125801213925 0.2603780509481517 1.2508969498248628 0.13507950887429807 0.3204483044414132 1.683511227586851e-07 6.77378398289172 1.0328569906361253 ILTTIEDLDQKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILTTIEDLDQKK 12 1 O95347;O95347-2;A0A0C4DGE5 O95347 SMC2 Structural maintenance of chromosomes protein 2 1 26975300.0 6696600.0 5087700.0 15191000.0 True False 8668880.709720626 4804565.022552266 12426393.8728227 1.0 0.5542312996837977 1.4334484795584606 23.04741429993637 -6.768859358163739 1.578712749167767 0.7439490306592059 1.4381953544580177 0.7262263537223788 0.18781512888300786 0.26827306250715327 1.3193671349031222 0.09378073208745402 0.22348121569727367 1.702709824322634e-07 6.768859358163739 0.6942463237988118 ILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNR 36 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 143577100.0 17868000.0 102841100.0 22868000.0 False True 27107062.325775377 84488302.20381834 18348129.77659955 1.0 3.1168372724579854 0.6768763636608753 24.69216543663914 -6.677268630961613 1.9113857282591633 2.342580957681876 0.6862974396885976 0.3118029469665392 0.8976997517920519 0.4445926665544075 3.1378930450172455 0.37717241223270315 0.9983367257937045 2.1024775591372766e-07 6.677268630961613 -1.6562835179932782 ILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNR 36 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 44052000.0 17868000.0 13119000.0 13065000.0 False True 23130478.23093634 12388916.117472166 10687304.05822057 1.0 0.5356100290612389 0.4620442323551535 24.46329175873159 -13.999999999999998 0.2593430368360374 4.3879432858095 0.4349867417257363 0.9995609959186352 0.004989951281546414 14.388138401592062 0.16115168039926384 25.53684239102712 0.03227357746793952 1.0000000000000041e-14 13.999999999999998 -3.952956544083764 ILVATNLFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILVATNLFGR 10 0 O00148;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 261649700.0 115280000.0 119883700.0 26486000.0 False True 151133196.37310806 101997519.26300259 23745482.79165203 1.0 0.6748849472567071 0.15711626142697788 27.17124534205507 -7.358653179207317 0.4891878691460602 1.013703385129421 1.7189847104617606e-24 0.9983267155518774 0.014197953514012929 0.10646559269539814 0.052130804598872454 0.01619687094619095 0.059904459118025166 4.3787164302964163e-08 7.358653179207317 -1.013703385129421 down ILVATNLFGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILVATNLFGR 10 0 O00148;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 324618400.0 143601400.0 98738000.0 82279000.0 False True 139042852.16043228 138164598.31186777 60727661.58290951 1.0 0.9936835742728354 0.43675500494509356 27.05095434040519 -6.9093775564409174 0.899961968085182 1.0175849201980738 0.36573113623519954 0.990684572728903 0.025484208972878005 0.10483111061040533 0.14101013001052376 0.020800260677944393 0.05717359212604163 1.2320332921926215e-07 6.9093775564409174 -0.6518537839628742 down ILVATNLFGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILVATNLFGR 10 0 O00148;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 482440000.0 122870000.0 185220000.0 174350000.0 False True 186402773.00022522 152166043.86953473 139889646.07968032 1.0 0.8163292928552671 0.7504697694572994 27.47384808134386 -13.99999999904704 0.14278838494218507 1.879764808892707 0.671639619305336 0.9995920522718146 0.0021326106534810935 11.937858395394878 0.11858689026708623 2.922045012624259 0.07061335525470698 1.0000000021942723e-14 13.99999999904704 -1.208125189587371 ILVATNLFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILVATNLFGR 10 0 O00148;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 497058800.0 115280000.0 157830000.0 223948800.0 False True 157902131.32486132 150856548.72598502 171056705.81031376 1.0 0.9553800665021993 1.0833084035983578 27.23445540357796 -6.812456883146428 1.4039582011308263 0.9757525366022586 1.0856795673791033 0.8662159143959928 0.019391638435346224 0.20345603439836712 0.7898853415627503 0.010858629359794952 0.02509409136636874 1.5400794178998343e-07 6.812456883146428 0.10992703077684474 ILVATNLFGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILVATNLFGR 10 0 O00148;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 281353400.0 143601400.0 68197000.0 69555000.0 False True 119410926.72066872 67829609.22495537 84098628.91401617 1.0 0.5680351965078151 0.7042791746415583 26.831359615839467 -10.847833637797992 10.777224700078014 1.008336480241274 0.6361571855746878 0.9048428444779264 0.055621371159096614 0.010929007882968779 0.00015430916663828034 0.05282926335609769 0.017951720349366894 1.4196012144275376e-11 10.847833637797992 -0.37217929466658617 ILVATNLFGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILVATNLFGR 10 0 O00148;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 464280000.0 122870000.0 188520000.0 152890000.0 False True 159057637.12979352 178028696.27760148 125065588.78387646 1.0 1.1192716017296753 0.7862910014300099 27.24497440343631 -6.809824764753932 1.415129177733055 1.0650154385421764 0.7804808766230409 0.8594085018189679 0.05164975876941451 0.2070360476477476 0.8171697396251993 0.028698196738399795 0.06639446104050127 1.549441683322958e-07 6.809824764753932 -0.2845345619191355 ILVQQTLNILQQLAVAMGPNIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILVQQTLNILQQLAVAMGPNIK 22 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 1793750000.0 687480000.0 566970000.0 539300000.0 False True 1042957421.5202633 465789773.7431709 432707118.6164132 1.0 0.4466047837928168 0.414884739959642 29.9580331153766 -13.908949486626417 0.4076588127511819 9.999545879792326 0.41333070889472534 0.9998469376158113 0.0033238349098091233 25.82190563686832 0.2111431148974515 205.55780023399072 0.007951949783714817 1.2332482656469129e-14 13.908949486626417 -9.5862151708976 ILVQQTLNILQQLAVAMGPNIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILVQQTLNILQQLAVAMGPNIK 22 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 1324660000.0 687480000.0 241820000.0 395360000.0 False True 889956412.2567787 228362504.42313603 323408536.73617184 1.0 0.2565996505874343 0.36339817577814015 29.72915943746905 -10.80584220734715 7.357840237350869 1.0257198099615008 0.3099989131827909 0.9823494501647005 0.04360031533316749 0.016035590250450822 0.0004231447232521758 0.036800236204102686 0.014071941264562461 1.5637156858407114e-11 10.80584220734715 -0.7157208967787099 ILVTGGSGLVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILVTGGSGLVGK 12 0 Q13630;E9PKL9;E9PP14;A0A0J9YX13;E9PLH9;E9PP60 Q13630 TSTA3 GDP-L-fucose synthase 0 10772500.0 4320000.0 6452500.0 0.0 False True 5917220.743610343 6167407.214435905 0.0 1.0 1.0422810778346783 0.0 22.49648828556668 -6.993812964896546 1.1313573987555854 1.0362549445905331 2.1761256623065884e-19 0.9822287959253466 0.06421207741314668 0.0934109062582504 0.23449433566744754 0.04774672613887255 0.0879037578889877 1.0143481351535678e-07 6.993812964896546 -1.0362549445905331 down ILVTGGSGLVGK(ub)AIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILVTGGSGLVGKAIQK 16 1 Q13630;E9PKL9;E9PP14;A0A0J9YX13;E9PLH9;E9PP60 Q13630 TSTA3 GDP-L-fucose synthase 1 24649200.0 6922200.0 8879200.0 8847800.0 True False 9075071.234680159 7554457.970850519 7932314.5300905835 1.0 0.8324406250367871 0.874077384624535 23.113477536897186 -10.78181550530137 6.977875590096002 1.0044064332967657 0.8532590048306625 0.9430557834883722 0.01699813592215295 0.0011942900296822137 3.734306107859653e-05 0.016868760347066126 0.005486124778589039 1.6526637250393188e-11 10.78181550530137 -0.15114742846610318 ILVTGGSGLVGK(ub)AIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILVTGGSGLVGKAIQK 16 1 Q13630;E9PKL9;E9PP14;A0A0J9YX13;E9PLH9;E9PP60 Q13630 TSTA3 GDP-L-fucose synthase 1 49053000.0 14554000.0 15848000.0 18651000.0 True False 14091991.236456838 22176189.04622823 13765743.581993531 1.0 1.5736732072935926 0.9768487186098098 23.748372146972535 -6.655181170561666 1.9903405572320985 1.370723394846702 0.9793669790493227 0.21525934495224053 0.2445412272500847 0.49592082709988483 3.7714229615701576 0.09945069660886134 0.2709065165578215 2.212171686150101e-07 6.655181170561666 -0.39135641579737923 ILVTGGSGLVGK(ub)AIQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILVTGGSGLVGKAIQK 16 1 Q13630;E9PKL9;E9PP14;A0A0J9YX13;E9PLH9;E9PP60 Q13630 TSTA3 GDP-L-fucose synthase 1 35190000.0 13850000.0 10918000.0 10422000.0 True False 21011462.570628453 8969597.597276656 8362087.131875121 1.0 0.42689068250846546 0.39797739466096627 24.324673253159798 -13.743925993454955 0.42791464921738637 9.999999999999998 0.3972991000669334 0.9998702590453228 0.003157782377957779 24.875350255881706 0.2189776722140957 208.2705859582512 0.006880179991155475 1.8033250127429554e-14 13.743925993454955 -9.602700899933065 ILVTGGSGLVGK(ub)AIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILVTGGSGLVGKAIQK 16 1 Q13630;E9PKL9;E9PP14;A0A0J9YX13;E9PLH9;E9PP60 Q13630 TSTA3 GDP-L-fucose synthase 1 28079300.0 6922200.0 8343100.0 12814000.0 True False 9481524.405421194 7974474.25505776 9787597.112613961 1.0 0.8410540240236309 1.0322809596964984 23.176687598420077 -6.6860693449403 1.8804487798479292 0.8999865851927007 1.0315896341432065 0.35209249689734157 0.06727744627634077 0.425156329060766 2.911645779934366 0.028655160096687077 0.07499002861388603 2.0603009133477663e-07 6.6860693449403 0.13160304895050579 ILVTGGSGLVGK(ub)AIQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILVTGGSGLVGKAIQK 16 1 Q13630;E9PKL9;E9PP14;A0A0J9YX13;E9PLH9;E9PP60 Q13630 TSTA3 GDP-L-fucose synthase 1 45321200.0 14554000.0 21608000.0 9159200.0 True False 12102295.851521043 21491593.41514781 11074346.37264406 1.0 1.7758277998506127 0.9150616138054675 23.52877742240681 -6.66924740636036 1.9400684662878536 1.495525256624259 0.9185531110213961 0.2757312039894205 0.32961140409097217 0.4628313087341414 3.3577660790857715 0.13681265009567348 0.3658844892177623 2.1416701992857358e-07 6.66924740636036 -0.5769721456028628 ILVTLLHTLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILVTLLHTLER 11 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 35989230.0 15301030.0 13005000.0 7683200.0 False True 20059798.50538528 11064704.693092959 6888216.166458547 1.0 0.5515860336345111 0.34338411547899284 24.25780377879865 -12.082552506011554 0.12528342370810427 2.3658427990162187 6.034251549301366e-20 0.9997327202428581 0.004479152066450067 5.710392277424219 0.08902046541286486 2.3045860512186627 0.2625107186405215 8.268895319443238e-13 12.082552506011554 -2.3658427990162187 ILVTLLHTLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILVTLLHTLER 11 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 80003950.0 32479950.0 19702000.0 27822000.0 False True 31448891.765875753 27569111.3445727 20534583.557890944 1.0 0.8766322053512586 0.6529509437331716 24.906505842777282 -6.9619169674879835 0.40751831043499753 1.0113214205809775 0.5099941438135254 0.9998348190570484 0.0018461110771558094 0.07902332300837506 0.01865251501963932 0.0028786890139582072 0.018690992921746235 1.0916490282476491e-07 6.9619169674879835 -0.5013272767674521 ILVTLLHTLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILVTLLHTLER 11 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 188574500.0 29670000.0 98273000.0 60631500.0 False True 45011559.16754843 80735415.33954652 48647657.44926956 1.0 1.7936596028371659 1.080781433679876 25.423792203703513 -10.223146961153107 4.395847475223105 0.9998486683432988 1.437220518265107 0.3340189186941692 0.2910312940600424 0.0004798507860849218 8.480049012652665e-05 0.2818973912548617 0.0939299462313009 5.982091324829656e-11 10.223146961153107 0.4373718499218082 ILVTLLHTLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILVTLLHTLER 11 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 124561330.0 15301030.0 34936800.0 74323500.0 False True 20958234.285788 33393176.65545203 56769820.04053101 1.0 1.5933201337526939 2.708711968117812 24.32101384032154 -6.961237552070493 0.4176265444719339 0.9494196986324009 3.3945244674830937 0.9998133793828191 0.009676693769930139 0.07926197238207416 0.01951951080514706 0.014408204761494308 0.09291007567037535 1.0933581534215177e-07 6.961237552070493 2.4451047688506926 ILVTLLHTLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILVTLLHTLER 11 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 72885850.0 32479950.0 15256000.0 25149900.0 False True 27008517.53075515 15173812.899921086 30408627.810000934 1.0 0.5618158376387136 1.1258902964731037 24.686911118211558 -6.699402005499615 1.8335013164587883 0.7277387601615124 1.1241663118243297 0.4145407175649898 0.18498388076748 0.3967523294893505 2.59274875710591 0.08051080547815793 0.20716715587202822 1.9980115502598584e-07 6.699402005499615 0.3964275516628173 ILVTLLHTLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILVTLLHTLER 11 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 75701900.0 29670000.0 6691900.0 39340000.0 False True 38408399.8831364 6319489.8823471265 32180523.662487395 1.0 0.1645340576950659 0.8378511929786636 25.194918525795963 -10.637346921195187 8.99444796915503 1.000272940898919 0.5011926253476332 0.4225507941610228 0.27488056941955435 0.0015052649562619744 6.069176399136239e-05 0.2662890833641923 0.08871732229649545 2.3049052589229917e-11 10.637346921195187 -0.49908031555128585 ILVVGAHGSLEAALQCLFQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ILVVGAHGSLEAALQCLFQR 20 0 A0A087WVM4;B7ZM99;Q6UB35;H0Y327;Q6UB35-2 A0A087WVM4 MTHFD1L Monofunctional C1-tetrahydrofolate synthase, mitochondrial 0 189575000.0 62947000.0 50233000.0 76395000.0 False True 95495201.04211909 41268528.677779585 61295494.764882065 1.0 0.43215290640183796 0.6418698960364206 26.508924898860485 -10.13372576409148 5.246795248805426 1.0000131949196946 0.5370114012187875 0.8666397217109088 0.08561660250075188 1.3215166801951833e-05 2.181893376275494e-06 0.08290027863265531 0.027632639636848942 7.349778245194516e-11 10.13372576409148 -0.4630017937009071 ILVVGAHGSLEAALQCLFQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILVVGAHGSLEAALQCLFQR 20 0 A0A087WVM4;B7ZM99;Q6UB35;H0Y327;Q6UB35-2 A0A087WVM4 MTHFD1L Monofunctional C1-tetrahydrofolate synthase, mitochondrial 0 104763000.0 62947000.0 14847000.0 26969000.0 False True 81486132.37087256 14020751.398438089 22060918.725308143 1.0 0.1720630368689562 0.27073218575279784 26.280051220952934 -10.623751779559129 6.5788643350418665 1.0026063319788485 0.221397612112569 0.9880987406709645 0.040281511353352735 0.0015426280523225357 8.822340035106512e-05 0.03907188374379274 0.013000801885966686 2.378199154862418e-11 10.623751779559129 -0.7812087198662795 ILYDILAFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILYDILAFAK 10 0 Q8IXB1;Q8IXB1-2 Q8IXB1 DNAJC10 DnaJ homolog subfamily C member 10 0 6678700.0 1383300.0 2382800.0 2912600.0 False True 1813519.6958962562 2027295.5280816513 2611232.091632022 1.0 1.117878969094816 1.4398697171808381 20.79036098323868 -6.953537133034772 0.5185608208216024 0.9944670489617516 1.5776156895286073 0.9994504227441597 0.004358268967826206 0.08209574570485871 0.03031918700066409 0.004948748796072825 0.02659292374503585 1.1129172321152564e-07 6.953537133034772 0.5831486405668557 ILYDILAFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ILYDILAFAK 10 0 Q8IXB1;Q8IXB1-2 Q8IXB1 DNAJC10 DnaJ homolog subfamily C member 10 0 8933500.0 3792700.0 2515800.0 2625000.0 False True 3672302.81451902 3520372.059723679 1937433.751688005 1.0 0.9586279338962301 0.5275800633945708 21.80825359621111 -6.925536123346742 0.7825737500093162 1.0077517528247664 0.4483748203115856 0.9955855849301147 0.01419301760996165 0.09502313517349843 0.08952997936561433 0.012602183983474631 0.04000241901594192 1.1870359627523738e-07 6.925536123346742 -0.5593769325131808 ILYDILAFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ILYDILAFAK 10 0 Q8IXB1;Q8IXB1-2 Q8IXB1 DNAJC10 DnaJ homolog subfamily C member 10 0 12535900.0 1383300.0 3555600.0 7597000.0 False True 1894743.3922768973 3398501.8352031456 5802745.06512629 1.0 1.7936475456548204 3.062549308143083 20.853571044761573 -6.964175487692524 0.37193621844390423 0.9045374754022576 3.9959622957882663 0.9998951208247885 0.00869926763611815 0.07824192731266698 0.015853667521951897 0.01667747766913137 0.1076561382415732 1.0859867144907433e-07 6.964175487692524 3.091424820386009 ILYDILAFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ILYDILAFAK 10 0 Q8IXB1;Q8IXB1-2 Q8IXB1 DNAJC10 DnaJ homolog subfamily C member 10 0 5906700.0 3792700.0 912500.0 1201500.0 False True 3153798.0950985183 907584.1813829307 1452728.094891673 1.0 0.2877749792523036 0.46062812237391904 21.588658871645386 -10.595176864581969 9.747200925034221 1.000070882992239 0.37420155082076967 0.9458770392164931 0.07056700018070494 0.0001087111414656926 4.515015870927267e-06 0.06833377013488137 0.02277540137430717 2.5399381158947245e-11 10.595176864581969 -0.6258693321714692 ILYLIQAWAHAFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILYLIQAWAHAFR 13 0 O14964;O14964-2;I3L2H4;I3L165 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 0 103359100.0 22009000.0 55870000.0 25480100.0 False True 28491084.362249684 52760785.38632284 20842983.24790404 1.0 1.8518349359924748 0.7315615995128891 24.764007195465066 -6.70341856702709 1.8187084190479137 1.527171178427923 0.7346739634375391 0.43382235242509104 0.35934966248266065 0.38844299203986904 2.5002437366122003 0.15749102820657382 0.40332045678595546 1.9796181774172733e-07 6.70341856702709 -0.7924972149903838 ILYSFCTAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILYSFCTAFK 10 0 Q5R372-4;Q5R372;Q5R372-3;A0A0C4DG54;Q5R372-2 Q5R372-4 RABGAP1L Rab GTPase-activating protein 1-like 0 4078600.0 1401100.0 1174800.0 1502700.0 False True 1836855.6682717009 999524.4193345323 1347215.0189162411 1.0 0.5441496774076897 0.7334354256498753 20.808806839840287 -10.202246817216276 5.434642455317829 1.000016682202218 0.6387925515287375 0.8292146318352827 0.07727558312920402 1.5620263466659523e-05 2.2929973395108177e-06 0.07482521358313012 0.02494058721063322 6.277015235747245e-11 10.202246817216276 -0.3612241306734806 ILYSQCGDVMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 ILYSQCGDVMR 11 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;F8W1I5;P14649 P60660-2 MYL6;MYL6B Myosin light polypeptide 6;Myosin light chain 6B 0 46388200.0 5552600.0 15495900.0 25339700.0 False True 7279512.371454884 13183972.12254512 22717790.919566 1.0 1.8111064931001923 3.120784711988287 22.795410381994607 -6.964004223881141 0.37475358752998594 0.9045588858153315 4.073262524047737 0.9998911184439692 0.009117209920157547 0.07830055977423096 0.01606174845163242 0.01714788626844101 0.11095384396095007 1.0864150572604143e-07 6.964004223881141 3.168703638232406 ILYSQCGDVMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 ILYSQCGDVMR 11 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;F8W1I5;P14649 P60660-2 MYL6;MYL6B Myosin light polypeptide 6;Myosin light chain 6B 0 13532540.0 7173000.0 2446940.0 3912600.0 False True 6945297.04130169 3424015.9026235263 2887772.684515999 1.0 0.4929977626963808 0.41578821860940474 22.727604967036775 -13.999999999999998 0.26496577393170057 4.8095957587052816 0.3888826243861062 0.9995726229958253 0.005356931714953883 14.642412037106745 0.16291255759981665 29.957094058743508 0.032894590507900834 1.0000000000000041e-14 13.999999999999998 -4.4207131343191755 ILYSQCGDVMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ILYSQCGDVMR 11 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;F8W1I5;P14649 P60660-2 MYL6;MYL6B Myosin light polypeptide 6;Myosin light chain 6B 0 41798300.0 5552600.0 12410100.0 23835600.0 False True 7605546.273372867 11861780.747287262 18206122.18959115 1.0 1.5596224545783828 2.393795466517778 22.8586204435175 -6.965361477822713 0.35179306637965263 0.921032233890452 3.060611355432114 0.9999204043227177 0.005109264811955485 0.07783850466147456 0.014428613819100674 0.011399177725906652 0.07161501963062003 1.083025100754351e-07 6.965361477822713 2.1395791215416624 ILYSQCGDVMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ILYSQCGDVMR 11 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;F8W1I5;P14649 P60660-2 MYL6;MYL6B Myosin light polypeptide 6;Myosin light chain 6B 0 1126600.0 0.0 1126600.0 0.0 False True 0.0 1063903.7196390084 0.0 0.0 ILYYIFTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ILYYIFTK 8 0 A0A0G2JNN3;C9JMY0;A0A087WUE4;Q96PV6-1;Q96PV6 A0A0G2JNN3 LENG8 Leukocyte receptor cluster member 8 0 4323900.0 1256900.0 1479800.0 1587200.0 False True 1647808.0718369132 1259019.6082152212 1422971.7694974751 1.0 0.7640571919348074 0.8635543142540871 20.652116783972705 -10.083405842509503 4.768175436734261 1.0000079115361193 0.8138057530918431 0.8236108537494861 0.040619530101770294 10317181.361030983 21818058.717274833 533.3509621569477 0.013905142944763053 8.252663884871016e-11 10.083405842509503 -0.18620215844427623 IMATPEQVGK(ub)MK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IMATPEQVGKMK 12 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 12781700.0 4648500.0 4685900.0 3447300.0 True False 6094228.516138036 3986781.985495136 3090606.4648365937 1.0 0.6541897756111045 0.5071366222406011 22.53901216730033 -13.999999999885775 0.1168744133199845 2.652752470324546 0.2622327823665677 0.9997084061367238 0.003527791239527412 11.976834660221554 0.10479698033837404 4.617868455625115 0.2173140925603405 1.000000000263013e-14 13.999999999885775 -2.3905196879579784 IMDPNIVGSEHYDVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IMDPNIVGSEHYDVAR 16 0 P06576;H0YH81 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 65939200.0 5658200.0 27923000.0 32358000.0 False True 7417954.994086739 23756997.243001528 29009904.559853386 1.0 3.202634319288745 3.91076847769753 22.82259008413128 -9.53315948524734 0.33245395687320894 1.1289112845939956e-19 4.114173951746294 0.9985459183772768 0.04726237289515749 0.8961113024262415 0.13565915897675115 1.2245182111264634 0.22006543501698073 2.9298171357518713e-10 9.53315948524734 4.114173951746294 IMDPNIVGSEHYDVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IMDPNIVGSEHYDVAR 16 0 P06576;H0YH81 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 62567700.0 16009000.0 4025700.0 42533000.0 False True 15500803.057883544 5633183.00374816 31392331.337350864 1.0 0.36341233307155546 2.025206772844266 23.885839624073267 -6.802871705712244 1.4441351735175705 0.6500299082916867 2.049810503317387 0.8404211772026067 0.27347153074736474 0.21669170642843408 0.8918665513669988 0.14895250904228544 0.3458243927708174 1.574447901090573e-07 6.802871705712244 1.3997805950257 up IMDPNIVGSEHYDVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IMDPNIVGSEHYDVAR 16 0 P06576;H0YH81 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 62121200.0 5658200.0 27179000.0 29284000.0 False True 7750189.447105565 25978141.911065973 22367722.322911426 1.0 3.351936373731862 2.886087169296877 22.885800145654173 -10.096922614581267 4.970634260352536 0.9999312511289175 3.119011771523799 0.965019863926086 0.19018214135719488 0.0001448979203177518 2.632585471187747e-05 0.18414892528295396 0.06138102218053801 7.999767873810742e-11 10.096922614581267 2.1190805203948817 IMDPNIVGSEHYDVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IMDPNIVGSEHYDVAR 16 0 P06576;H0YH81 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 23556900.0 16009000.0 3709600.0 3838300.0 False True 13312192.818950118 3689615.6485020514 4640870.78370596 1.0 0.27716062249713097 0.34861805615522684 23.666244899507543 -10.321333114302771 5.7239820620302835 1.00008960858242 0.3128893393502705 0.9919537382773844 0.029172375131867025 3.336394762625991e-05 3.9558238924072544e-06 0.028249674266780815 0.00941534358791759 4.771631376663084e-11 10.321333114302771 -0.6872002692321495 IMDYSLLLGIHDIIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IMDYSLLLGIHDIIR 15 0 H0YIJ6;Q8TBX8-2;Q8TBX8-3;Q8TBX8 H0YIJ6 PIP4K2C Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 0 8513400.0 3975400.0 0.0 4538000.0 False True 5146233.666849361 0.0 3712130.563812089 1.0 0.0 0.7213295788966261 22.29508553404287 -10.62443343729055 8.89916233717522 1.0002907373396528 0.3606647912706396 0.511584822590249 0.2944815674455658 0.0016993861101457226 7.171806953500855e-05 0.2852500726357394 0.09504351720681105 2.3744693209808722e-11 10.62443343729055 -0.6396259460690132 IMEEK(ub)ALEVYDLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IMEEKALEVYDLIR 14 1 H0YKV4;Q9H5X1;Q9H5X1-2 H0YKV4 FAM96A MIP18 family protein FAM96A 1 10510700.0 1106800.0 2322600.0 7081300.0 True False 1071665.2398316904 3250026.2921989947 5226495.095553629 1.0 3.032687980725609 4.876984809523608 20.031422885326585 -7.14133493572364 0.21294667298349693 2.5837849189023983e-12 7.6507666778846914 0.9999900003466758 0.005007045057238484 0.08392040131161595 0.008954752944661781 0.07497832158113683 0.22505798550374637 7.222126054048787e-08 7.14133493572364 7.650766677882108 IMEEK(ub)ALEVYDLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IMEEKALEVYDLIR 14 1 H0YKV4;Q9H5X1;Q9H5X1-2 H0YKV4 FAM96A MIP18 family protein FAM96A 1 7410100.0 1106800.0 1313000.0 4990300.0 True False 920353.239553627 1305926.6083899066 6033748.657459783 1.0 1.4189406330804935 6.555905274355489 19.81182816076086 -6.923083584490241 0.8015138931579131 0.8987538318976254 7.446068587489913 0.994995722058475 0.17870077175350985 0.09639123188115437 0.09645695269155746 0.15653910916305921 0.483680391079014 1.1937583311464601e-07 6.923083584490241 6.5473147555922875 up IMGLDLPDGGHLTHGYMSDVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IMGLDLPDGGHLTHGYMSDVK 21 0 P34897;P34897-3;P34897-2;G3V5L0;G3V4W5;G3V540;G3V2W0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial 0 11524900.0 2633900.0 5532100.0 3358900.0 False True 3453068.4067238863 4706732.243956905 3011353.24884392 1.0 1.36305792112078 0.872080391740908 21.719447484188443 -6.708604646894559 1.799980354110924 1.223514704248085 0.8732706591498391 0.45855703698480066 0.15302421492463608 0.37789009246567845 2.3857173273363386 0.06767304830883589 0.17222564717035466 1.956119367790459e-07 6.708604646894559 -0.3502440450982458 IMGLDLPDGGHLTHGYMSDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IMGLDLPDGGHLTHGYMSDVK 21 0 P34897;P34897-3;P34897-2;G3V5L0;G3V4W5;G3V540;G3V2W0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial 0 24975700.0 6814700.0 1600000.0 16561000.0 False True 6598371.0786781795 2238888.3438897748 12223177.28064956 1.0 0.3393092502973144 1.852453754858869 22.65367848367972 -6.788008555429151 1.5041363655449018 0.6297871573926943 1.8677121540183397 0.7948686170421898 0.2805306104590859 0.23832266975563807 1.0651894533264912 0.14681561774099644 0.3442578012377493 1.6292639364698294e-07 6.788008555429151 1.2379249966256454 IMGLDLPDGGHLTHGYMSDVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IMGLDLPDGGHLTHGYMSDVK 21 0 P34897;P34897-3;P34897-2;G3V5L0;G3V4W5;G3V540;G3V2W0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial 0 22507300.0 2633900.0 6244400.0 13629000.0 False True 3607724.008471136 5968501.760530576 10410110.89806585 1.0 1.6543676141845116 2.8855064504996317 21.782657545711334 -6.961222416381343 0.4178491014810976 0.9443048592335334 3.641847439251081 0.9998128833542421 0.010692471748502344 0.07926730635719874 0.019538979862051723 0.015905350475057107 0.10254502365153229 1.093396258942551e-07 6.961222416381343 2.6975425800175477 IMGLDLPDGGHLTHGYMSDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IMGLDLPDGGHLTHGYMSDVK 21 0 P34897;P34897-3;P34897-2;G3V5L0;G3V4W5;G3V540;G3V2W0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial 0 11918400.0 6814700.0 3026600.0 2077100.0 False True 5666724.992397986 3010295.105066934 2511412.006574693 1.0 0.5312230801927567 0.44318579248927686 22.434083759113996 -13.999999999999977 0.2351705994368986 4.031829915076792 0.4024341451021351 0.9995172744319112 0.005369524484245374 13.457858525623081 0.15351308726950139 19.107978409000847 0.044273871730017886 1.0000000000000532e-14 13.999999999999977 -3.629395769974657 IMGPNYTPGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IMGPNYTPGK 10 0 P13639 P13639 EEF2 Elongation factor 2 0 10526900.0 2575500.0 1358300.0 6593100.0 False True 2493742.1622574246 1900676.2734409252 4866169.321239689 1.0 0.7621783447412883 1.9513522267413 21.249880876327282 -6.854698238423601 1.212156160345526 0.8723779979626988 2.0033925615426456 0.946874064402295 0.11842237178908525 0.1523626684762654 0.4284398253854334 0.0763430581941614 0.17728277707179674 1.3973389392236804e-07 6.854698238423601 1.1310145635799467 IMHFPTWVDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IMHFPTWVDLK 11 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 11182500.0 3127000.0 4695900.0 3359600.0 False True 4099527.281911078 3995290.024474838 3011980.819558795 1.0 0.9745733470548712 0.7347141785954158 21.967026130918 -6.927165446558863 0.7697018590043896 1.0040565194843172 0.688847605442944 0.9959512395990217 0.007604750917899675 0.09413663137587981 0.08508773496739994 0.006814861155721832 0.022051064198420345 1.1825909562238904e-07 6.927165446558863 -0.3152089140413732 IMHFPTWVDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IMHFPTWVDLK 11 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 16527600.0 6752100.0 3413400.0 6362100.0 False True 6537758.281412679 4776388.420645846 4695675.151091148 1.0 0.7305850438407099 0.7182393335711559 22.640364607081874 IMHFPTWVDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IMHFPTWVDLK 11 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 13526600.0 3127000.0 5325300.0 5074300.0 False True 4283136.403997584 5090010.637587836 3875854.848488916 1.0 1.1883839685416442 0.9049104401324835 22.030236192440892 -6.727535064047372 1.732111863426862 1.113677067020164 0.9051499487099742 0.5478664124661248 0.07920855891331931 0.3408694067606742 2.002345818899734 0.03625516516568202 0.09022051623511715 1.8726858800895655e-07 6.727535064047372 -0.20852711831018966 IMHFPTWVDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IMHFPTWVDLK 11 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 12496300.0 6752100.0 2423100.0 3321100.0 False True 5614670.318747778 2410046.2793523073 4015526.6549685746 1.0 0.4292409246728153 0.715184761883605 22.42076988251615 -10.504937551226483 6.3425913225415895 1.000309919533797 0.572212843278222 0.7490106666013706 0.11673608270998202 0.0005119507714378795 3.995968620510298e-05 0.113108783969268 0.03767640868643763 3.126528909696756e-11 10.504937551226483 -0.428097076255575 IMILFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IMILFR 6 0 A0A0A0MR50;Q13619-2;Q13619 A0A0A0MR50 CUL4A Cullin-4A 0 4471100.0 1346000.0 1477600.0 1647500.0 False True 1764619.0346825412 1257147.8396396884 1477032.5039359191 1.0 0.7124188365483953 0.8370262787070302 20.750925321603276 -10.113920306294538 4.741304364357436 1.000014175687393 0.7747225576251714 0.8133628303295934 0.05087077524906568 7.623231689635442e-06 1.4246662580178191e-06 0.04925851406562777 0.016418472111119884 7.692715898556651e-11 10.113920306294538 -0.22529161806222164 IMILFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IMILFR 6 0 A0A0A0MR50;Q13619-2;Q13619 A0A0A0MR50 CUL4A Cullin-4A 0 7200300.0 1346000.0 2353500.0 3500800.0 False True 1843652.5742822974 2249514.588016257 2673983.1412391867 1.0 1.2201401822639795 1.4503725802461036 20.814135383126168 -6.970560556419787 0.24443392509576925 0.921745118353059 1.7554635667229992 0.9999864278439349 0.0006773939428549866 0.07612128923257483 0.008377031219816198 0.005334943309897981 0.022272091227678956 1.0701371565320887e-07 6.970560556419787 0.8337184483699402 IMILFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IMILFR 6 0 A0A0A0MR50;Q13619-2;Q13619 A0A0A0MR50 CUL4A Cullin-4A 0 9186700.0 2247900.0 4333000.0 2605800.0 False True 2909950.8627334773 4091864.7409868785 2131571.137765876 1.0 1.4061628302352722 0.7325110417031488 21.472563361396134 -6.743454743743213 1.6740295089236903 1.2406931986543792 0.7318095207918859 0.6203550242780691 0.1706453564298001 0.3116023428055906 1.7158437711125962 0.08059996786161447 0.19704142394001656 1.8052828493248072e-07 6.743454743743213 -0.5088836778624933 IMK(ub)AQALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IMKAQALR 8 1 P08238;P07900;P07900-2;Q58FG1 P08238;P07900;Q58FG1 HSP90AB1;HSP90AA1;HSP90AA4P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A4 1 15019600.0 4619300.0 8627400.0 1772900.0 True False 6055947.0333648315 7340225.549341811 1589457.3148576573 1.0 1.2120689809374707 0.2624622220274797 22.529921156577135 -6.848092206035821 1.2442977748215835 1.1130079116423253 0.22588259752600534 0.9374772328370718 0.10176331603238381 0.15956924221814564 0.476389232660226 0.06402672389197572 0.14798925677006358 1.4187562703837167e-07 6.848092206035821 -0.8871253141163199 down IMK(ub)AQALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IMKAQALR 8 1 P08238;P07900;P07900-2;Q58FG1 P08238;P07900;Q58FG1 HSP90AB1;HSP90AA1;HSP90AA4P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A4 1 16606000.0 5732400.0 8245300.0 2628300.0 True False 5550428.0997571135 11537691.288671482 1939869.3826901289 1.0 2.078702954313807 0.34949905625748356 22.40416761890905 -6.737993518082456 1.6938261015218399 1.6432913072565525 0.34887520328822713 0.5960305517293871 0.45325082868537053 0.3214404127931106 1.8099713635032506 0.21174932829780838 0.5208061531333552 1.8281275010468465e-07 6.737993518082456 -1.2944161039683253 IMK(ub)AQALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IMKAQALR 8 1 P08238;P07900;P07900-2;Q58FG1 P08238;P07900;Q58FG1 HSP90AB1;HSP90AA1;HSP90AA4P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A4 1 21109600.0 7558000.0 4524000.0 9027600.0 True False 11466038.563812984 3716656.8538266653 7243290.903062358 1.0 0.3241448066951823 0.6317169493849697 23.450863700595846 -10.50626431413648 6.293409259495723 1.0004078000458267 0.4779308780403625 0.7934524109807272 0.12556580144741308 0.0007190023512176957 5.640770204173225e-05 0.1216692618153968 0.040526188154918145 3.1169919873358034e-11 10.50626431413648 -0.5224769220054643 IMK(ub)AQALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IMKAQALR 8 1 P08238;P07900;P07900-2;Q58FG1 P08238;P07900;Q58FG1 HSP90AB1;HSP90AA1;HSP90AA4P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A4 1 13310000.0 4619300.0 6476100.0 2214600.0 True False 6327180.041888719 6189964.488401146 1691557.0911186899 1.0 0.9783133161093652 0.26734770939341646 22.593131218100027 -6.91340978894375 0.872199765189283 1.0197111047443868 0.16843952540499113 0.9921456945178869 0.03016593946740549 0.10220641134029539 0.12685901132799438 0.025121340622281222 0.07109867391244104 1.2206473456109132e-07 6.91340978894375 -0.8512715793393957 down IMK(ub)AQALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IMKAQALR 8 1 P08238;P07900;P07900-2;Q58FG1 P08238;P07900;Q58FG1 HSP90AB1;HSP90AA1;HSP90AA4P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A4 1 31557500.0 5732400.0 23407000.0 2418100.0 True False 4766744.588378391 23280901.84507428 2923713.52996884 1.0 4.884025441982882 0.613356448150595 22.184572894343326 -6.6673415500935675 1.947011012921358 3.4848368541183508 0.6309010473527451 0.2672331962791564 1.6508738597875479 0.4672530536881173 3.4123349335605586 0.6832676386663958 1.8317289684340443 2.1510893490772338e-07 6.6673415500935675 -2.8539358067656058 IMK(ub)AQALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IMKAQALR 8 1 P08238;P07900;P07900-2;Q58FG1 P08238;P07900;Q58FG1 HSP90AB1;HSP90AA1;HSP90AA4P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A4 1 17361100.0 7558000.0 5378500.0 4424600.0 True False 9783979.990453152 5079181.746918524 3619368.2002298306 1.0 0.5191324749104763 0.36992800514325225 23.221990022688296 -13.999999999999998 0.16386967470970706 3.388598742000153 0.22933977063845104 0.9995267292342894 0.005848607002662678 12.037720260400011 0.1280454693137972 9.137488424906044 0.12878493363383275 1.0000000000000041e-14 13.999999999999998 -3.1592589713617016 IMK(ub)SEVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IMKSEVLR 8 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 13773800.0 2911500.0 5571800.0 5290500.0 True False 4416958.35916135 4577468.7573279 4244830.356091471 1.0 1.0363395769474781 0.9610301956519779 22.074621800770704 -6.775491415451827 1.5533998884894702 1.0206968800658074 0.9605154552464619 0.7511263062862904 0.015340912830768778 0.25764309944965774 1.2276177396154724 0.007780905815460544 0.018430352040165177 1.6769054822291924e-07 6.775491415451827 -0.06018142481934552 IMK(ub)SEVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IMKSEVLR 8 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 6672900.0 2911500.0 3761400.0 0.0 True False 3768994.1442450825 3552074.7834636606 0.0 1.0 0.9424463524007756 0.0 21.845748122863153 -7.072720541151864 1.0222986762050643 1.0063683807034225 7.345587764220891e-21 0.9888195730310178 0.04847447613165857 0.08440330117479924 0.168807278787673 0.039345747071942334 0.0699688813712174 8.458229383503788e-08 7.072720541151864 -1.0063683807034225 down IMLK(ub)GDNITLLQSVSN ddPTM_RPMI8226_Bortezomib_2h_R1 2 IMLKGDNITLLQSVSN 16 1 P62304;A6NHK2 P62304 SNRPE Small nuclear ribonucleoprotein E 1 127441900.0 23654400.0 53029700.0 50757800.0 True False 22903504.01976395 74204735.75623219 37462809.4786398 1.0 3.2398857263150322 1.6356802629987226 24.449064998132688 -6.559651698763718 2.3471627371611437 2.543441618543935 1.6381335859183186 0.0 0.9780493659436095 0.7627207890501051 7.873914717033184 0.35450050132701766 1.1007851381605702 2.7564384621119573e-07 6.559651698763718 -0.9053080326256162 IMLK(ub)GDNITLLQSVSN ddPTM_RPMI8226_Bortezomib_8h_R1 1 IMLKGDNITLLQSVSN 16 1 P62304;A6NHK2 P62304 SNRPE Small nuclear ribonucleoprotein E 1 48734800.0 12213000.0 8420800.0 28101000.0 True False 18528013.88989782 6918042.447989297 22546825.032894157 1.0 0.3733828401198079 1.216904583884598 24.14320490419705 -6.70777734312316 1.8032197449297442 0.6138997893582311 1.2147902889150775 0.45453049591328687 0.26414609902696845 0.37954292316539096 2.4043239679038657 0.11663634923241836 0.2971023299118873 1.9598492040230785e-07 6.70777734312316 0.6008904995568464 IMLK(ub)GDNITLLQSVSN ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IMLKGDNITLLQSVSN 16 1 P62304;A6NHK2 P62304 SNRPE Small nuclear ribonucleoprotein E 1 11737400.0 1116200.0 4043500.0 6577700.0 True False 1528889.3041708048 3864844.799933598 5024182.731983832 1.0 2.5278774528609196 3.2861651384949053 20.544052524678836 -9.113749859073252 0.23862672757402184 4.2224985331417835e-23 3.845807304972558 0.9992388216652877 0.026231695770752222 0.5591456636650413 0.08406791314424099 0.7927081908057122 0.3397894824921733 7.695735645388805e-10 9.113749859073252 3.845807304972558 IMLK(ub)GDNITLLQSVSN ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IMLKGDNITLLQSVSN 16 1 P62304;A6NHK2 P62304 SNRPE Small nuclear ribonucleoprotein E 1 71092200.0 23654400.0 32648000.0 14789800.0 True False 19669681.667597864 32472118.74387939 17882278.799691126 1.0 1.6508715948042594 0.9091290393961408 24.229470273566964 -6.67492684694825 1.9198004387333685 1.4136776293850501 0.9120491995021072 0.30105786953136926 0.2761667094016398 0.4499282544345446 3.2014718957208155 0.11561463542111015 0.30693457692169845 2.1138450682953655e-07 6.67492684694825 -0.501628429882943 IMLK(ub)GDNITLLQSVSN ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IMLKGDNITLLQSVSN 16 1 P62304;A6NHK2 P62304 SNRPE Small nuclear ribonucleoprotein E 1 40713000.0 12213000.0 16583000.0 11917000.0 True False 15809969.254221242 15660141.472371453 9748228.278745854 1.0 0.9905232085249132 0.6165874279700506 23.914331226289498 -6.912344722056438 0.8796202830975332 1.0107369306934397 0.5657588853691214 0.9917766374881143 0.016191463330720274 0.102887730212432 0.1305095673867729 0.01341180885929484 0.03765242169819953 1.2236445435466201e-07 6.912344722056438 -0.4449780453243183 IMLK(ub)LNPYAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 IMLKLNPYAK 10 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 61684400.0 17117400.0 17182800.0 27384200.0 True False 16574017.506591044 24043981.647118278 20211456.511609428 1.0 1.450703285281111 1.2194663426397294 23.982420015371105 -10.089710850092818 4.281346562493793 0.9999602434051111 1.3350848138310798 0.7368312807525836 0.09440208669290316 13531454.02014795 10629715.1675169 4716.9430177385275 0.0323163458984928 8.133718726307406e-11 10.089710850092818 0.33512457042596866 IMLK(ub)LNPYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IMLKLNPYAK 10 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 56323230.0 17117400.0 28794800.0 10411030.0 True False 14233876.529395776 28639676.697079692 12587928.237836093 1.0 2.012078483182925 0.8843640179005015 23.76282529080538 -6.670201947196887 1.9371402824073383 1.6459043882370814 0.888964142525159 0.27979482130982447 0.4298904573340188 0.4606160284826417 3.3326642267999373 0.17866666761203887 0.4771428318376513 2.136968166942088e-07 6.670201947196887 -0.7569402457119224 IMLPWDPTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IMLPWDPTGK 10 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 0 13445200.0 2663100.0 4515200.0 6266900.0 False True 3491349.8894970864 3841549.760111753 5618461.30434962 1.0 1.1003050057137387 1.609251860219296 21.73535351474183 -6.939478470345353 0.6644020490909056 0.9942327607367755 1.7444163263327725 0.998094737328505 0.01164232378302713 0.08800542241625851 0.055700116926233244 0.011288617007542056 0.04390566578928432 1.1495332288088038e-07 6.939478470345353 0.7501835655959971 IMLPWDPTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IMLPWDPTGK 10 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 0 8410700.0 2899600.0 1742700.0 3768400.0 False True 2807553.7851607967 2438569.1980604446 2781342.9904232714 1.0 0.8685743478715869 0.9906641878506259 21.42088223036198 -10.443585281107996 6.596170392196487 1.000015039987858 0.9296192678621402 0.3070402211136758 0.049842968454449264 1.1026505891823976e-05 9.30144772612542e-07 0.04827055726064477 0.01608674889580195 3.600930330601805e-11 10.443585281107996 -0.07039577212571779 IMLPWDPTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IMLPWDPTGK 10 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 0 13675400.0 2663100.0 5425000.0 5587300.0 False True 3647720.037571463 5185305.5619240245 4267694.814055567 1.0 1.4215196091025224 1.1699622696090635 21.798563576264723 -10.278696376974098 4.838583955636657 0.9999043286484605 1.2957409393559112 0.6482390927478976 0.10269785380298081 0.00010603389987063763 1.580681288423718e-05 0.09946882412824305 0.03314558978902033 5.263851430323806e-11 10.278696376974098 0.2958366107074507 IMLPWDPTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IMLPWDPTGK 10 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 0 5308990.0 2899600.0 1574700.0 834690.0 False True 2411145.8740600804 1566216.7785465221 1009219.8198294898 1.0 0.6495736302794493 0.41856439740416235 21.201287505796255 -8.35442561000087 0.15374871931312306 1.3916173113632915 1.3183235391028735e-09 0.9999078642621776 0.002294408109429663 0.10258897887740732 0.034557166112587086 0.14233628415001032 0.13617982085752936 4.421548467851382e-09 8.35442561000087 -1.391617310044968 down IMLPWDPTGK(ub)IGPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IMLPWDPTGKIGPK 14 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 52150900.0 7192000.0 6738900.0 38220000.0 True False 9428781.647427075 5733482.388026458 34265361.03212797 1.0 0.6080830591289608 3.634123931746611 23.168639932507407 -6.87434331840946 1.1109109345200119 0.7713285017026255 3.826571151717581 0.9688267436374417 0.237238354210644 0.13275626855632505 0.3035992933606099 0.16526257305617317 0.3944834077637034 1.3355393287805216e-07 6.87434331840946 3.0552426500149554 up IMLPWDPTGK(ub)IGPK ddPTM_RPMI8226_Bortezomib_2h_R1 2 IMLPWDPTGKIGPK 14 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 189637600.0 37821400.0 40980200.0 110836000.0 True False 36620780.35938769 57343807.56891975 81804726.59127316 1.0 1.5658816389536532 2.2338335171577692 25.12615919834579 -6.968933312567099 0.2825027825333014 0.857211372861428 2.9629276667849935 0.999972826191356 0.002628753961848303 0.07665035786250171 0.01026335416622708 0.012162684247153575 0.061118308567909396 1.0741543398248092e-07 6.968933312567099 2.1057162939235656 IMLPWDPTGK(ub)IGPK ddPTM_RPMI8226_Bortezomib_8h_R1 2 IMLPWDPTGKIGPK 14 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 397389300.0 47762900.0 60697000.0 288929400.0 True False 72459811.23571613 49865146.12217452 231822377.4477454 1.0 0.6881765943325493 3.1993235076698343 26.11067771165812 -6.875791396313848 1.1029633024840526 0.8156527782919336 3.363552452144451 0.9701309915875688 0.19314103523939505 0.1314252544278635 0.2953479884834453 0.13536041826346606 0.3241198153387783 1.3310936256415896e-07 6.875791396313848 2.5478996738525175 up IMLPWDPTGK(ub)IGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 IMLPWDPTGKIGPK 14 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 280902800.0 21982000.0 28451300.0 230469500.0 True False 30109339.441213563 27194227.49013251 176037350.7683457 1.0 0.9031824674608817 5.846602882539043 24.843707721814514 -6.902435644300019 0.9457591200707722 0.8079796027075228 6.391914539878465 0.987739117510819 0.2555477371045676 0.10963402267130223 0.16748836206857956 0.20169165687383533 0.5314691675265052 1.251884769175374e-07 6.902435644300019 5.583934937170943 up IMLPWDPTGK(ub)IGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IMLPWDPTGKIGPK 14 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 236288650.0 37821400.0 57684650.0 140782600.0 True False 31450169.87211198 57373891.34094344 170219590.75480384 1.0 1.8242792192934696 5.412358389381668 24.906564473780065 -6.942936682047802 0.6316516617240062 0.9608550418023568 6.469708997481329 0.9985238126255727 0.07359621515120432 0.0864520662372172 0.04869774849773017 0.07334834301267228 0.3050489137547035 1.140416042367252e-07 6.942936682047802 5.508853955678973 IMLPWDPTGK(ub)IGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IMLPWDPTGKIGPK 14 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 346875100.0 47762900.0 54737200.0 244375000.0 True False 61830015.59751447 51691026.70213417 199901257.4992461 1.0 0.8360183351500257 3.233077908317429 25.88180403375057 -6.890510550506604 1.0193311595049983 0.8727755656694226 3.4413419261202534 0.9812239892689979 0.14982175104697693 0.11873092465572219 0.21942297045214923 0.11191338197483364 0.2795267113168806 1.2867359934073116e-07 6.890510550506604 2.5685663604508306 up IMNLTVMLDTALGKPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IMNLTVMLDTALGKPR 16 1 Q96RS6;Q96RS6-2 Q96RS6 NUDCD1 NudC domain-containing protein 1 0 111488000.0 31638000.0 46149000.0 33701000.0 False True 47997159.047620445 37913350.38621725 27039982.578326948 1.0 0.789908218288534 0.5633663140666136 25.516445679436874 -6.9701635672179725 0.25424921553709856 1.0682381210991587 0.2783651466075676 0.9999836294914057 0.0007213756942853097 0.0762496825852442 0.008840053397376467 0.004910695036344937 0.021564368664605038 1.0711158176541321e-07 6.9701635672179725 -0.7898729744915911 IMNLTVMLDTALGKPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IMNLTVMLDTALGKPR 16 1 Q96RS6;Q96RS6-2 Q96RS6 NUDCD1 NudC domain-containing protein 1 0 9627200.0 5619500.0 2105400.0 1902300.0 False True 4672863.2360603595 2094057.7923108195 2300062.1347585777 1.0 0.4481316243435143 0.4922168740161407 22.15587538278521 -9.858948716140787 6.832869762932084 1.0000000084620724 0.470174250774221 0.994834260207802 0.017997727813565338 2.317797597754165e-09 3.8003211279023734e-10 0.01742622528252979 0.005808741674286376 1.3837297676766034e-10 9.858948716140787 -0.5298257576878513 IMNLTVMLDTALGKPR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IMNLTVMLDTALGKPR 16 1 Q96RS6;Q96RS6-2 Q96RS6 NUDCD1 NudC domain-containing protein 1 0 92110800.0 36781100.0 24434000.0 30895700.0 False True 47613859.0138735 23074226.42078778 25272999.61665256 1.0 0.4846115584553758 0.5307908272943941 25.504878225568696 -10.10072735001279 7.870973174974246 1.0000000411223104 0.5077011938511612 0.9934439656829134 0.018852607558400375 1.3599282230166622e-08 1.5551107999750165e-09 0.01825396040858812 0.006084652925522407 7.929990188621869e-11 10.10072735001279 -0.49229884727114925 IMNMIK(ub)LYGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IMNMIKLYGK 10 1 Q15427;Q5SZ64 Q15427 SF3B4 Splicing factor 3B subunit 4 1 17379500.0 3116300.0 7469100.0 6794100.0 True False 4727654.932046885 6136180.748655339 5451243.157040178 1.0 1.2979332960746819 1.1530543653024203 22.172693307463916 -10.183599352566755 4.314439014863166 0.9999322633338296 1.2254938306989234 0.7635913331016753 0.05914657584693687 3.8548626770079296e-05 7.2944354480394114e-06 0.057285602265546826 0.019089475265168954 6.55240370828031e-11 10.183599352566755 0.2255615673650938 IMNMIK(ub)LYGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IMNMIKLYGK 10 1 Q15427;Q5SZ64 Q15427 SF3B4 Splicing factor 3B subunit 4 1 13354900.0 3116300.0 4957000.0 5281600.0 True False 4034111.781456618 4681138.5924468 4320402.9937924035 1.0 1.1603889148447337 1.0709675953085298 21.943819629556366 -10.2542012352467 4.869709955720185 0.9999729967729525 1.1156782550767586 0.6905280509565832 0.03650610083217575 1.0705300339935122e-05 1.6395025603173787e-06 0.035355128179548355 0.011782293379761211 5.569276304362083e-11 10.2542012352467 0.11570525830380607 IMNSDENK(ub)MQEEEEVVDK ddPTM_RPMI8226_Bortezomib_1h_R1 3 IMNSDENKMQEEEEVVDK 18 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 85907420.0 48870100.0 25684220.0 11353100.0 True False 64069174.35872158 21852234.49230542 10178390.118625104 1.0 0.3410725159334089 0.15886563578354504 25.93312706323169 -13.999999999999998 0.18036040991720087 4.422657421996012 0.014666516185540443 0.9994977080024389 0.008097588439561461 12.209417800620162 0.13463246350925703 14.645615553296345 0.1356266227800866 1.0000000000000041e-14 13.999999999999998 -4.407990905810472 IMNSDENK(ub)MQEEEEVVDK ddPTM_RPMI8226_Bortezomib_2h_R1 2 IMNSDENKMQEEEEVVDK 18 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 53022300.0 26111600.0 16892300.0 10018400.0 True False 25282701.550767235 23637483.48218074 7394280.494442322 1.0 0.9349271253594904 0.29246401851458526 24.591647293298358 -6.9264063615235205 0.7757315886169256 1.0111811812953775 0.1718834545147117 0.9957833668747964 0.020734255911112796 0.09454748425862493 0.0871425292603835 0.018500585569861474 0.0593220693242895 1.1846597646183093e-07 6.9264063615235205 -0.8392977267806658 down IMNSDENK(ub)MQEEEEVVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 3 IMNSDENKMQEEEEVVDK 18 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 94115500.0 48870100.0 32346400.0 12899000.0 True False 66938696.634794414 30917229.092759322 9852521.863243908 1.0 0.4618737837313775 0.14718723785432378 25.996337124754582 -8.545232293919014 0.30824232961543585 1.1740500863899566 5.1953139830599036e-21 0.9986329955882497 0.01301894302068753 0.19232608588065545 0.08766093032997122 0.1253938663473333 0.09542306056694597 2.849493732543778e-09 8.545232293919014 -1.1740500863899566 IMNSDENK(ub)MQEEEEVVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 3 IMNSDENKMQEEEEVVDK 18 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 75994800.0 31332900.0 35245100.0 9416800.0 True False 26054694.63282417 35055227.650695436 11385809.341636224 1.0 1.345447649443269 0.43699646079490706 24.635040010353407 -6.803657880642433 1.440944345637112 1.1897233334930049 0.42329539559373514 0.8426401963179664 0.1485199773144382 0.21557700200462288 0.8832667661623036 0.0810720548952283 0.18813846533672854 1.571600359043728e-07 6.803657880642433 -0.7664279378992698 down IMNSDENK(ub)MQEEEEVVDKMDDDVFLR ddPTM_RPMI8226_Bortezomib_2h_R1 3 IMNSDENKMQEEEEVVDKMDDDVFLR 26 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 122154400.0 66327300.0 34058200.0 21768900.0 True False 64221776.16722846 47657816.8711667 16066972.036998492 1.0 0.7420818874126042 0.25017950290196517 25.93655923011946 -7.052505396867883 0.44595254567259973 1.0172121097430862 1.5813798179423595e-11 0.9997517581739647 0.004900668249484192 0.07365159057646672 0.022166117975173493 0.006731452865596248 0.037718290534040605 8.861242119492133e-08 7.052505396867883 -1.0172121097272724 down IMNSDENK(ub)MQEEEEVVDKMDDDVFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IMNSDENKMQEEEEVVDKMDDDVFLR 26 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 103483600.0 44422600.0 45276000.0 13785000.0 True False 67392331.92707573 37196144.05699738 11060388.707819877 1.0 0.5519343669135354 0.16411939447040005 26.006081111403123 -7.8724331721076135 0.36500592618518607 1.0705204810327411 6.893847302108816e-20 0.9984757188618356 0.013334503966761252 0.10904740678063757 0.06748219566477029 0.04063276301669505 0.08199080541917028 1.3414263340626458e-08 7.8724331721076135 -1.0705204810327411 down IMNSDENK(ub)MQEEEEVVDKMDDDVFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IMNSDENKMQEEEEVVDKMDDDVFLR 26 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 7608200.0 2716100.0 2365300.0 2526800.0 True False 3720315.5698426086 2260793.2249988755 1930021.8810795175 1.0 0.6076885636598082 0.5187790779697672 21.82699357015684 -13.999999999999961 0.2085752503548506 3.255695833530538 0.4656824099210428 0.9994892608389833 0.004724848162313067 12.713713659804286 0.1447646186970505 11.74446839407523 0.05319621298106651 1.00000000000009e-14 13.999999999999961 -2.790013423609495 IMNSDENK(ub)MQEEEEVVDKMDDDVFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 3 IMNSDENKMQEEEEVVDKMDDDVFLR 26 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 139530700.0 66327300.0 56120100.0 17083300.0 True False 55154088.74760143 55817769.88233232 20655339.045745265 1.0 1.0120332172972353 0.37450240797684353 25.716964505553737 -6.902601419545505 0.9446996085266706 1.0246476135244587 0.3039379451980481 0.987816021972085 0.032864765177401285 0.10951493804398359 0.16682724762216014 0.02595902531551536 0.06846471313053566 1.2514070014163475e-07 6.902601419545505 -0.7207096683264105 down IMNSDENK(ub)MQEEEEVVDKMDDDVFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IMNSDENKMQEEEEVVDKMDDDVFLR 26 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 161121300.0 66503600.0 64722300.0 29895400.0 True False 86090221.1819396 61120447.109525785 24454743.95270778 1.0 0.7099580680639245 0.284059485699614 26.359346038261847 -7.097361116048911 0.3738271830410646 1.0344527705260684 5.17092561878505e-12 0.9998734667781766 0.0033074540333391305 0.07606996585397952 0.017531291372308824 0.006500996561042102 0.035852188898697714 7.991694689024791e-08 7.097361116048911 -1.0344527705208975 down IMNTFSVMPSPK ddPTM_RPMI8226_Bortezomib_1h_R1 2 IMNTFSVMPSPK 12 0 Q13885;Q9BUF5;K7ESM5;K7ES63;Q9BVA1 Q13885;Q9BUF5;Q9BVA1 TUBB2A;TUBB6;TUBB2B Tubulin beta-2A chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 41122600.0 12642700.0 12880400.0 15599500.0 False True 16574702.132080955 10958694.527405972 13985413.380970184 1.0 0.6611699226977363 0.843780676691673 23.98247960776623 -10.175793634143071 4.941179358391199 1.000020944352318 0.7524752996941866 0.7101245642760685 0.07455052814013473 1.7202302171057828e-05 2.869338486722662e-06 0.07218934202461705 0.02406107949455303 6.671236943755724e-11 10.175793634143071 -0.24754564465813145 IMNTFSVMPSPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IMNTFSVMPSPK 12 0 Q13885;Q9BUF5;K7ESM5;K7ES63;Q9BVA1 Q13885;Q9BUF5;Q9BVA1 TUBB2A;TUBB6;TUBB2B Tubulin beta-2A chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 20480400.0 6618300.0 2636100.0 11226000.0 False True 6408205.689174255 3688708.4770798953 8285573.827218886 1.0 0.5756226713058601 1.292963152106084 22.61148902512154 -6.746439842245637 1.6633647076399307 0.7493978982523105 1.2939828821617025 0.6334090685842546 0.17830203725735053 0.3062753044263876 1.6661611564513685 0.08472609722529462 0.20643911814197868 1.7929168870517306e-07 6.746439842245637 0.544584983909392 IMNTFSVMPSPK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 IMNTFSVMPSPK 12 0 Q13885;Q9BUF5;K7ESM5;K7ES63;Q9BVA1 Q13885;Q9BUF5;Q9BVA1 TUBB2A;TUBB6;TUBB2B Tubulin beta-2A chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 38568100.0 12642700.0 11953600.0 13971800.0 False True 17317047.846120954 11425450.426730892 10671948.59825346 1.0 0.6597804965521424 0.6162683555005591 24.04568966928912 -13.999999999999998 0.28995157574272384 3.9308627270583627 0.6044053661174417 0.999627353134998 0.0033117818979920494 15.963067116458966 0.1707611400538152 27.906293837614918 0.01643727910285811 1.0000000000000041e-14 13.999999999999998 -3.326457360940921 IMNTFSVMPSPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IMNTFSVMPSPK 12 0 Q13885;Q9BUF5;K7ESM5;K7ES63;Q9BVA1 Q13885;Q9BUF5;Q9BVA1 TUBB2A;TUBB6;TUBB2B Tubulin beta-2A chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 15873400.0 6618300.0 4842700.0 4412400.0 False True 5503409.690402746 4816611.413899316 5335012.439367477 1.0 0.875204951995284 0.9694012874729401 22.391894300555816 -10.08519416042596 4.838753560794025 1.0000029099266643 0.922303119850331 0.475656687288204 0.03845549292929354 53458211.694711655 8.646895900794128 1733.2158996791516 0.013164338085456095 8.218751313430724e-11 10.08519416042596 -0.07769979007633332 IMNTFSVVPSPK ddPTM_RPMI8226_Bortezomib_1h_R1 2 IMNTFSVVPSPK 12 0 A0A0B4J269;Q13509;Q13509-2;G3V2A3;P04350;M0R2D3;P07437;Q5JP53;Q5ST81;P68371;M0QYM7;M0R042 A0A0B4J269;P04350;P07437;P68371;M0QYM7 TUBB3;TUBB4A;TUBB;TUBB4B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain 0 332435000.0 86319000.0 111126000.0 134990000.0 False True 113165044.91438508 94546433.9657554 121022529.7155142 1.0 0.835473834144496 1.0694338504179774 26.75385315793695 -6.717733097531367 1.767484075787775 0.8996600443052979 1.06902226580387 0.501720949277201 0.06925357820136883 0.35977754337038503 2.195308617789217 0.03112603651624799 0.0783467385254004 1.9154327225220283e-07 6.717733097531367 0.16936222149857205 IMNTFSVVPSPK ddPTM_RPMI8226_Bortezomib_2h_R1 2 IMNTFSVVPSPK 12 0 A0A0B4J269;Q13509;Q13509-2;G3V2A3;P04350;M0R2D3;P07437;Q5JP53;Q5ST81;P68371;M0QYM7;M0R042 A0A0B4J269;P04350;P07437;P68371;M0QYM7 TUBB3;TUBB4A;TUBB;TUBB4B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain 0 205165900.0 58203000.0 30278900.0 116684000.0 False True 56355377.623711474 42369422.6723775 86120959.95503359 1.0 0.7518257255816986 1.5281764329585164 25.74804994809418 -6.820701999945784 1.3687745271581768 0.8663245232593783 1.5453880289582533 0.8859864752797549 0.10931443851685883 0.19258325922569203 0.7087771248293759 0.06275383579506782 0.14461533627648976 1.511116682169012e-07 6.820701999945784 0.6790635056988751 IMNTFSVVPSPK ddPTM_RPMI8226_Bortezomib_8h_R1 2 IMNTFSVVPSPK 12 0 A0A0B4J269;Q13509;Q13509-2;G3V2A3;P04350;M0R2D3;P07437;Q5JP53;Q5ST81;P68371;M0QYM7;M0R042 A0A0B4J269;P04350;P07437;P68371;M0QYM7 TUBB3;TUBB4A;TUBB;TUBB4B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain 0 411426000.0 39188000.0 345682000.0 26556000.0 False True 59451061.026555106 283992346.2742063 21307194.96009173 1.0 4.776909635765036 0.3583989014186712 25.825199222274808 -6.680366837793798 1.9004052005402678 3.388942324464887 0.3751293576124025 0.3257888332632046 1.600624128251881 0.4377661093912418 3.0569963756554324 0.6757239251414787 1.7814560596360915 2.087532099274362e-07 6.680366837793798 -3.0138129668524845 IMNTFSVVPSPK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 IMNTFSVVPSPK 12 0 A0A0B4J269;Q13509;Q13509-2;G3V2A3;P04350;M0R2D3;P07437;Q5JP53;Q5ST81;P68371;M0QYM7;M0R042 A0A0B4J269;P04350;P07437;P68371;M0QYM7 TUBB3;TUBB4A;TUBB;TUBB4B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain 0 322417000.0 86319000.0 119577000.0 116521000.0 False True 118233466.98326425 114293692.7517399 89001139.62532315 1.0 0.9666780114628456 0.7527575896756974 26.81706321945984 -6.934420749535716 0.7095637520798126 1.0027812430078151 0.7034497361624678 0.997338034322807 0.005651892033448829 0.09040644990692578 0.06690467423916338 0.005291983863457819 0.01890775690602801 1.1629987567446569e-07 6.934420749535716 -0.2993315068453474 IMNTFSVVPSPK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IMNTFSVVPSPK 12 0 A0A0B4J269;Q13509;Q13509-2;G3V2A3;P04350;M0R2D3;P07437;Q5JP53;Q5ST81;P68371;M0QYM7;M0R042 A0A0B4J269;P04350;P07437;P68371;M0QYM7 TUBB3;TUBB4A;TUBB;TUBB4B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain 0 122715200.0 58203000.0 37107000.0 27405200.0 False True 48398373.33008649 36907097.2258372 33135500.612671945 1.0 0.7625689602029285 0.6846407912654682 25.528455223528457 -13.999999999999998 0.15574539730058246 2.1594208332221245 0.6043199668808535 0.9995482084806497 0.0028508034143867574 11.984010211269842 0.12455633303328302 4.199433759031797 0.07283431967971664 1.0000000000000041e-14 13.999999999999998 -1.555100866341271 IMNTFSVVPSPK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IMNTFSVVPSPK 12 0 A0A0B4J269;Q13509;Q13509-2;G3V2A3;P04350;M0R2D3;P07437;Q5JP53;Q5ST81;P68371;M0QYM7;M0R042 A0A0B4J269;P04350;P07437;P68371;M0QYM7 TUBB3;TUBB4A;TUBB;TUBB4B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain 0 134750000.0 39188000.0 59649000.0 35913000.0 False True 50729638.510965645 56329480.7143149 29377202.498497963 1.0 1.1103860064395847 0.5790934719975942 25.596325544367257 -6.852501888255256 1.2229866057957814 1.059054763331584 0.5568100848356078 0.9438674389154288 0.054235279111012155 0.15472234320769312 0.44407334976955726 0.03467812785699195 0.08038471152920319 1.4044235773157744e-07 6.852501888255256 -0.5022446784959763 IMNVIGEPIDER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IMNVIGEPIDER 12 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 29385400.0 1836400.0 15542000.0 12007000.0 False True 2407538.183722896 13223194.182241486 10764630.81927682 1.0 5.492413068105032 4.4712191449570025 21.199127248817963 -10.2488173538773 6.180983000613651 0.9999094196420518 4.9818161065310225 0.9529886175548413 0.4169006733572888 0.0005203982559392048 6.324404265643182e-05 0.4036708396138564 0.1345541137446168 5.638747481382291e-11 10.2488173538773 3.9819066868889705 IMNVIGEPIDER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IMNVIGEPIDER 12 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 31896200.0 11449000.0 4511200.0 15936000.0 False True 11085557.76186576 6312545.685597213 11761883.530247632 1.0 0.5694387076591063 1.0610096291869435 23.402178024406286 -6.675307874331749 1.9182209130983217 0.7264342007329714 1.0590870864613815 0.3027769138401767 0.18267362294245745 0.449126842131498 3.190793664436513 0.07652358241740645 0.20307220456569972 2.1119913039260113e-07 6.675307874331749 0.3326528857284101 IMNVIGEPIDER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IMNVIGEPIDER 12 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 40306400.0 1836400.0 22608000.0 15862000.0 False True 2515366.70684399 21609103.805341616 12115722.288144426 1.0 8.590836376479826 4.816682297328299 21.262337310340854 -10.537827017713706 8.6938636250946 0.9994528686686848 6.703759336904062 0.752796025985067 1.540791950760826 0.01633956178975252 0.0008686362862131966 1.4918290133114767 0.4972884637722598 2.8984978481525753e-11 10.537827017713706 5.704306468235377 IMQDFESDTFFPEIDLEK(ub)YK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IMQDFESDTFFPEIDLEKYK 20 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 12567100.0 4387700.0 2345500.0 5833900.0 True False 4248414.865205557 3282070.381620915 4305826.576751485 1.0 0.772539990974284 1.0135136782464746 22.01849322406094 -11.068369592975648 11.348759374883576 1.6385352925900865 0.8930268346103793 0.20808005879779456 0.09837709587564536 0.04122417418844261 0.00024835174526670697 0.002470606856284689 0.03175107116455206 8.543393441758746e-12 11.068369592975648 -0.7455084579797071 IMQDFESDTFFPEIDLEK(ub)YK ddPTM_RPMI8226_Bortezomib_8h_R1 2 IMQDFESDTFFPEIDLEKYK 20 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 699945300.0 33572300.0 79790000.0 586583000.0 True False 50931633.563892394 65550851.09788454 470644612.9415381 1.0 1.2870361013583578 9.240713089461911 25.602058654699125 -6.914543143577867 0.8642145786594532 0.7876904726084447 10.375139733260069 0.9925261973274865 0.33014423212598115 0.10149021489017082 0.12303537689642675 0.27651796341188845 0.7896318603497484 1.217466041619194e-07 6.914543143577867 9.587449260651624 up IMQDFESDTFFPEIDLEK(ub)YK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IMQDFESDTFFPEIDLEKYK 20 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 343257300.0 33572300.0 32563000.0 277122000.0 True False 43460004.15896936 30750840.424822487 226688639.51184073 1.0 0.7075664399925298 5.216028941981965 25.373184976791574 -6.8914156081527524 1.0140002116539113 0.7659110689010787 5.614683397634224 0.9817879790169334 0.27798003508681307 0.11800094898797871 0.21521299250794085 0.2084898051798212 0.5224737422264439 1.2840572634801532e-07 6.8914156081527524 4.848772328733145 up IMQSSSEVGYDAMAGDFVNMVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IMQSSSEVGYDAMAGDFVNMVEK 23 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 19003900.0 6510900.0 2356000.0 10137000.0 False True 6304215.043386471 3296763.0863776905 7481815.596518597 1.0 0.522945848720089 1.1867957461837384 22.58788531679864 -6.713838485799915 1.7814728011329795 0.7078780041502003 1.1854239540540026 0.48335625477903155 0.2009113630968567 0.3674005215351913 2.2751869602352532 0.08966863872714773 0.2267506541207069 1.9326869500215738e-07 6.713838485799915 0.4775459499038023 IMQSSSEVGYDAMAGDFVNMVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IMQSSSEVGYDAMAGDFVNMVEK 23 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 2206820.0 638210.0 686180.0 882430.0 False True 874173.4839767489 655862.2987061802 674018.2082163201 1.0 0.7502656060014109 0.7710348352710359 19.73756009241921 -10.694613195087737 6.695423171958415 1.0021594300541097 0.7606502206362235 0.9943844732908126 0.008479002343576429 0.00027547633867741514 1.2564811660837286e-05 0.008274674432883981 0.0027365862390937583 2.020164824937593e-11 10.694613195087737 -0.24150920941788623 IMQSSSEVGYDAMAGDFVNMVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IMQSSSEVGYDAMAGDFVNMVEK 23 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 11318000.0 6510900.0 2152900.0 2654200.0 False True 5414101.831776025 2141301.900382807 3209180.948365777 1.0 0.39550454847658106 0.5927448444967736 22.368290592232917 -10.192777273255228 4.80195184490513 1.0000671832364358 0.49412469648489404 0.8976532177617149 0.08052301366694542 226263412.56011477 21.9405565623623 168285.56808727243 0.02756516936388195 6.41538503511344e-11 10.192777273255228 -0.5059424867515419 IMRPDDANVAGNVHGGTILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IMRPDDANVAGNVHGGTILK 20 1 O00154-4;O00154-6;O00154-7;O00154;O00154-2;O00154-3 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 24298300.0 6368200.0 9428600.0 8501500.0 False True 8348771.869736532 8021889.632394949 7621846.332146404 1.0 0.9608466679360951 0.9129302430426731 22.993132557598983 -6.968418013165904 0.2935236173042773 1.008976599679669 0.8633125714729906 0.9999672527865888 0.00020367438863550931 0.07681944394177337 0.010857916537605967 0.0008216262846984823 0.0043278655196412365 1.0754296026183334e-07 6.968418013165904 -0.14566402820667834 IMRPDDANVAGNVHGGTILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IMRPDDANVAGNVHGGTILK 20 1 O00154-4;O00154-6;O00154-7;O00154;O00154-2;O00154-3 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 18735500.0 6368200.0 6562000.0 5805300.0 False True 8722695.63413413 6272069.142367829 4434207.7039064905 1.0 0.7190517020705874 0.5083529094554562 23.056342619121875 -7.380657070836558 0.1414700889197412 1.307501992385509 1.8341951368705528e-10 0.9999930120735515 0.0005323524481962163 0.1195793829435092 0.009917639846220955 0.031022095250801584 0.055543485279291975 4.1623915301450296e-08 7.380657070836558 -1.3075019922020894 IMTEK(ub)ELLAVACEQFLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IMTEKELLAVACEQFLGK 18 1 E7EMK3;J3QLD9;Q14254 E7EMK3 FLOT2 Flotillin-2 1 5052590.0 2655100.0 1834100.0 563390.0 True False 3480861.8120249775 1560459.4292658065 505095.8072184868 1.0 0.44829686253991663 0.14510653812041144 21.73101311045744 -8.68990739973635 0.2990556981564962 1.2027879113940048 7.356660616738846e-23 0.9986949467742843 0.012784461201107388 0.2652741335389256 0.09086129672533422 0.15386760109182812 0.09726915373362034 2.042173330421732e-09 8.68990739973635 -1.2027879113940048 IMTEK(ub)ELLAVACEQFLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IMTEKELLAVACEQFLGK 18 1 E7EMK3;J3QLD9;Q14254 E7EMK3 FLOT2 Flotillin-2 1 10719500.0 6059100.0 3436100.0 1224300.0 True False 5866757.187083653 4808152.649024778 903619.1017872852 1.0 0.8195588287871337 0.15402360673400758 22.484131852412474 -7.046997600673137 0.6460842234317747 1.0031564608711387 1.8435539748091838e-19 0.9985745623992911 0.013735361305830899 0.07544108192384857 0.0486517383783564 0.01381633548989566 0.048470319651485634 8.974337524982634e-08 7.046997600673137 -1.0031564608711387 down IMTEK(ub)ELLAVACEQFLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IMTEKELLAVACEQFLGK 18 1 E7EMK3;J3QLD9;Q14254 E7EMK3 FLOT2 Flotillin-2 1 5913200.0 2655100.0 1181000.0 2077100.0 True False 3636762.221379593 1128819.514955259 1586531.759217296 1.0 0.3103913443444882 0.4362484162122237 21.79422317198033 -10.6599094463642 5.885751872994315 1.0062424819314526 0.3733198802858238 0.9706382404628419 0.05138093443279065 0.004220485906331807 0.00024386789589007235 0.049886961163825544 0.016583125280897778 2.188217836111314e-11 10.6599094463642 -0.6329226016456289 IMTEK(ub)ELLAVACEQFLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IMTEKELLAVACEQFLGK 18 1 E7EMK3;J3QLD9;Q14254 E7EMK3 FLOT2 Flotillin-2 1 9137400.0 6059100.0 1445800.0 1632500.0 True False 5038410.113642369 1438011.1884311698 1973848.2021728328 1.0 0.2854097137780637 0.3917601302101821 22.26453712784675 -10.544828712306836 6.664266793789821 1.0006124789864277 0.3385849219941229 0.9809782333583088 0.04341737569853227 0.0003954325653491696 2.7008150065750397e-05 0.04207388967625607 0.0140128977513705 2.8521429436806122e-11 10.544828712306836 -0.6620275569923049 IMYDIFPFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IMYDIFPFK 9 0 Q9NVM9;F5H457;F5H5W1 Q9NVM9 ASUN Protein asunder homolog 0 2325220.0 601980.0 846340.0 876900.0 False True 789201.6095826125 720069.3710074815 786166.7998187605 1.0 0.9124023091999354 0.9961545823944061 19.59003437288866 -10.446068486892155 5.723068075513594 1.0000308980884018 0.9542784458094264 0.2843663672860792 0.03419172235410529 1.3488941299530228e-05 1.3055954907588358e-06 0.03312836092080703 0.011035330937966438 3.580399708580915e-11 10.446068486892155 -0.0457524522789754 IMYDIFPFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IMYDIFPFK 9 0 Q9NVM9;F5H457;F5H5W1 Q9NVM9 ASUN Protein asunder homolog 0 2021740.0 601980.0 543000.0 876760.0 False True 824548.273897814 519008.464539123 669687.3454390061 1.0 0.6294458201769804 0.812186947252042 19.65324443441155 -10.117194288790675 5.065664601472858 1.0000094165587923 0.7208163837138934 0.7568120525271229 0.07460375272798045 7.93424462469806e-06 1.3827385973753343e-06 0.07223720798737819 0.024078257656362553 7.63494145481544e-11 10.117194288790675 -0.2791930328448988 IMYTVFEHTFHVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IMYTVFEHTFHVR 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 25582000.0 10548000.0 11299000.0 3735000.0 False True 13828530.146977289 9613233.243157044 3348538.0286498666 1.0 0.6951739006953211 0.24214706791392485 23.721144482857518 -7.205288637505914 0.40526141128503324 1.0280286070363656 1.987301421658649e-22 0.9996580631400037 0.005757481406241237 0.08920051045073099 0.02622314541611243 0.009121999078905553 0.04467363151850748 6.233204312893112e-08 7.205288637505914 -1.0280286070363656 down IMYTVFEHTFHVR ddPTM_RPMI8226_Bortezomib_2h_R1 2 IMYTVFEHTFHVR 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 65704000.0 29171100.0 13978800.0 22554100.0 False True 28245079.397952814 19560607.738479003 16646504.601503426 1.0 0.6925315189553599 0.5893594550387404 24.75149622035914 -13.999999999999998 0.15252761588836913 2.4928237243472084 0.47908333627805166 0.9995580223847 0.003666913090257524 11.968097115825469 0.12312271036349554 5.291650555897349 0.09964854863358226 1.0000000000000041e-14 13.999999999999998 -2.0137403880691567 IMYTVFEHTFHVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IMYTVFEHTFHVR 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 59827000.0 11374000.0 19082000.0 29371000.0 False True 17255189.550781775 15676668.011653492 23565808.976233397 1.0 0.9085190264364981 1.3657229847797128 24.040526986288114 -6.854671867520482 1.2122881267136052 0.9509102428273999 1.3857204352869554 0.9468362908563641 0.04554465023541215 0.15239331044431265 0.42863369869533424 0.029358098537263653 0.06817334461000883 1.397423789964618e-07 6.854671867520482 0.43481019245955554 IMYTVFEHTFHVR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 IMYTVFEHTFHVR 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 56695800.0 15030800.0 18934700.0 22730300.0 False True 20588092.952096857 18098102.345320325 17361871.285223104 1.0 0.8790567629274798 0.8432967213437237 24.295306865431204 -13.999999999997208 0.17079449943189093 1.611199080519298 0.8120176019843974 0.9995121776412679 0.0014809138023441828 12.099351375947 0.13088580275006206 2.4502617544755494 0.028945166789544313 1.0000000000064298e-14 13.999999999997208 -0.7991814785349005 IMYTVFEHTFHVR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IMYTVFEHTFHVR 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 56711900.0 29171100.0 15791600.0 11749200.0 False True 24257062.14884601 15706527.516412823 14205903.397837099 1.0 0.6475032887344123 0.5856398978024188 24.531901495793417 -13.999999999999998 0.24477872471390444 3.388395558381283 0.5595002596713297 0.9995331539959498 0.00394332915381609 13.796991113041189 0.15656923490766247 16.152683476999094 0.02940275511476826 1.0000000000000041e-14 13.999999999999998 -2.8288952987099534 IMYTVFEHTFHVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IMYTVFEHTFHVR 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 91392000.0 11374000.0 53807000.0 26211000.0 False True 14723867.215058742 50812593.149845615 21440866.947571356 1.0 3.4510358187608046 1.4561980649786657 23.811653308380563 -6.595097653650924 2.2085656018362685 2.65359653460586 1.4622672506478611 0.006716534908671634 1.0607437314083437 0.654990363794372 6.0301599259319705 0.39969171592934577 1.1815329272766972 2.540401417226077e-07 6.595097653650924 -1.1913292839579988 INAANYASVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 INAANYASVK 10 0 Q96IU4;F8W9U3;B4DQI4;Q96IU4-2 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 5933200.0 1383500.0 3217200.0 1332500.0 False True 1813781.8978330588 2737206.3005473753 1194625.6822425576 1.0 1.5091154585992614 0.658638000340497 20.790569555602914 -6.744550362172639 1.6697712338486945 1.301306485774415 0.6575995276911197 0.6253242235849952 0.2139010915301021 0.309633262160148 1.6966805654637434 0.10126754856549122 0.24729666581275203 1.800734303443289e-07 6.744550362172639 -0.6437069580832953 INAANYASVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INAANYASVK 10 0 Q96IU4;F8W9U3;B4DQI4;Q96IU4-2 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 6532600.0 1383500.0 2608200.0 2540900.0 False True 1895017.3376816937 2492961.0998359877 1940791.751478134 1.0 1.3155347184769297 1.0241551424814082 20.853779617125806 -10.457210064318849 3.645602658871771 0.9982321428891047 1.1698449304669247 0.3117823348759041 0.11895521418620456 85731634.0588882 2859.901888684939 1283337.9193221899 0.04072149731040011 3.489714802963407e-11 10.457210064318849 0.17161278757782006 INAANYASVK(ub)TPALIVYGDQDPMGQTSFEHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INAANYASVKTPALIVYGDQDPMGQTSFEHLK 32 1 Q96IU4;F8W9U3;Q96IU4-2 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 1 36012900.0 9801900.0 10422000.0 15789000.0 True False 12688752.77433484 9842006.538325699 12915564.008820873 1.0 0.7756480651299968 1.017874982555007 23.597046932388793 -11.116359847562387 12.081856921664988 3.6283585839579637 0.8967615238424986 0.19497772507261146 0.09888872494309174 0.03637602867975035 0.0003503367217465752 0.0004974875414294662 0.03191619873602335 7.649625118911369e-12 11.116359847562387 -2.7315970601154653 INAGMLAQFIDKPVCFVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 INAGMLAQFIDKPVCFVGR 19 1 P35244 P35244 RPA3 Replication protein A 14 kDa subunit 0 8126400.0 4136500.0 2121100.0 1868800.0 False True 5422991.557922976 1804640.1479830425 1675434.502795415 1.0 0.3327757619955112 0.30895023252389353 22.370657493807457 INAGMLAQFIDKPVCFVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 INAGMLAQFIDKPVCFVGR 19 1 P35244 P35244 RPA3 Replication protein A 14 kDa subunit 0 46096000.0 20699000.0 14307000.0 11090000.0 False True 20041921.575059738 20019859.71001939 8185196.3071314255 1.0 0.998899214081957 0.4084037688939529 24.256517501781918 -6.907305783884034 0.913884269984598 1.0198770099208534 0.33633098310527715 0.9898645604435703 0.028050251306821903 0.10622679162378677 0.14863008447258327 0.022663476773965668 0.061453187030707304 1.2379246650068e-07 6.907305783884034 -0.6835460268155762 down INAGMLAQFIDKPVCFVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 INAGMLAQFIDKPVCFVGR 19 1 P35244 P35244 RPA3 Replication protein A 14 kDa subunit 0 26395000.0 7068000.0 19327000.0 0.0 False True 10722672.740014577 15877945.847459776 0.0 1.0 1.4807824720982943 0.0 23.3541612218875 -6.841219812036338 1.426412980309657 1.2577605377299534 8.291140815921675e-21 0.881970266260045 0.21190099599661977 0.18316315829891222 0.748329313462655 0.11917395228712539 0.25456334255824203 1.441385629832128e-07 6.841219812036338 -1.2577605377299534 down INAGMLAQFIDKPVCFVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INAGMLAQFIDKPVCFVGR 19 1 P35244 P35244 RPA3 Replication protein A 14 kDa subunit 0 18370800.0 4136500.0 3415300.0 10819000.0 False True 5665875.834709299 3264400.7531132014 8263775.024299239 1.0 0.5761511279713191 1.4585167881151127 22.433867555330348 -6.776074211399742 1.550990142544536 0.7587795553318724 1.4646848432026445 0.7532925097130025 0.1789681904701876 0.25673402963111797 1.2195258684954495 0.09090634573116402 0.21523107691312876 1.6746566894847198e-07 6.776074211399742 0.7059052878707721 INAGMLAQFIDKPVCFVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INAGMLAQFIDKPVCFVGR 19 1 P35244 P35244 RPA3 Replication protein A 14 kDa subunit 0 47121300.0 20699000.0 3334100.0 23088200.0 False True 17212135.621178616 3316138.5415329672 27915835.872224685 1.0 0.1926628173585058 1.621869388356186 24.036922777216194 -6.753438356143123 1.6367794955960595 0.5272297991465715 1.6255222546177723 0.6636670792353133 0.3393279189510024 0.29413791315212534 1.5513429012778814 0.16368617208168038 0.39601511113803256 1.7642561656237244e-07 6.753438356143123 1.0982924554712008 INAGMLAQFIDKPVCFVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INAGMLAQFIDKPVCFVGR 19 1 P35244 P35244 RPA3 Replication protein A 14 kDa subunit 0 27701000.0 7068000.0 10482000.0 10151000.0 False True 9149665.33110914 9898667.485581458 8303622.1580556575 1.0 1.0818611530987574 0.9075328831780426 23.12528754397995 -6.779054386851594 1.5399558235808277 1.0464096100594882 0.9062025353882025 0.7638861180928469 0.03460355363940092 0.25205211971219466 1.1806385295352972 0.017700853668849534 0.04179273605674705 1.6632043536583645e-07 6.779054386851594 -0.14020707467128568 INAK(ub)LCDPHPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 INAKLCDPHPSK 12 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77;A0A0D9SF91;A0A0D9SES7 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 4716600.0 1687900.0 1811300.0 1217400.0 True False 2212853.2456468535 1541061.1003921 1091435.126125395 1.0 0.6964136024039056 0.49322526393129634 21.077476345452727 -8.24324856513153 0.12672883408072347 1.4471268556697625 8.456191129757465e-13 0.9999625753457352 0.0012739026246497806 0.08536960494750948 0.02591525459414789 0.1349612763160681 0.1382541180688709 5.711516488199767e-09 8.24324856513153 -1.447126855668917 INAK(ub)LCDPHPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INAKLCDPHPSK 12 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77;A0A0D9SF91;A0A0D9SES7 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 3924380.0 1687900.0 1343700.0 892780.0 True False 2311962.2437823876 1284330.8909783051 681923.7513812615 1.0 0.5555155126050546 0.29495453622358 21.140686406975618 -8.835938044854643 0.19464672269043587 1.3784875648232195 1.4145094449433719e-11 0.9996575374455069 0.005386647019261097 0.3475476749435151 0.059071859969494975 0.22015491638555257 0.1380108745943995 1.459022385177601e-09 8.835938044854643 -1.3784875648090744 down INAK(ub)LNYVPLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INAKLNYVPLEK 12 1 A0A0C4DG89;Q7L014 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 1 8107200.0 2525600.0 3965500.0 1616100.0 True False 3459382.571773682 3790291.0978451115 1234410.464624271 1.0 1.0956553717913216 0.3568297055943624 21.722083138941475 -6.8743493700784315 1.1107907146484939 1.0558236807388692 0.30982006786833977 0.9688364315622625 0.057915232145051544 0.1327549986545136 0.3035139385675405 0.04034625388696018 0.09631466713475567 1.3355207188604283e-07 6.8743493700784315 -0.7460036128705294 down INAK(ub)LNYVPLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INAKLNYVPLEK 12 1 A0A0C4DG89;Q7L014 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 1 10274400.0 3278200.0 5460300.0 1535900.0 True False 2725968.5488839005 5430884.280115308 1857049.5888007663 1.0 1.9922769403700156 0.6812439525617793 21.378337486334875 -6.70426708398657 1.8154426394854126 1.6135580990789906 0.6847863919477107 0.43796230753428866 0.41853323074125615 0.3867023217226092 2.480616650618202 0.18370984066964202 0.4700173561910597 1.9757542099666384e-07 6.70426708398657 -0.9287717071312799 INALK(ub)QLQVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 INALKQLQVR 10 1 Q99733;Q99733-2;C9J6D1;C9JZI7;E9PKT8;E9PNW0;E9PJJ2;E9PS34;E9PNJ7;E9PKI2;A8MXH2;C9J1B1 Q99733 NAP1L4 Nucleosome assembly protein 1-like 4 1 4893030.0 725430.0 2151400.0 2016200.0 True False 951045.7550741133 1830419.5060915197 1807582.964756052 1.0 1.92463874248498 1.9006267102419172 19.859155225649463 -10.474675377762177 7.6053159102332035 0.9999077351392419 1.9126327263634486 0.9994810783981457 0.009802871113793549 1.533737990181408e-05 1.0594101360910504e-06 0.009492523845026406 0.0031638630473950274 3.352159094816275e-11 10.474675377762177 0.9127249912242067 INALK(ub)QLQVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 INALKQLQVR 10 1 Q99733;Q99733-2;C9J6D1;C9JZI7;E9PKT8;E9PNW0;E9PJJ2;E9PS34;E9PNJ7;E9PKI2;A8MXH2;C9J1B1 Q99733 NAP1L4 Nucleosome assembly protein 1-like 4 1 9797400.0 2385300.0 4161100.0 3251000.0 True False 2309579.9571472085 5822648.929849837 2399465.5720905564 1.0 2.5210856683403025 1.0389185984512848 21.139199062158873 -6.6400858743201026 2.0436244189705026 1.9945961250728563 1.0450086328321253 0.15516838502527985 0.6508037962113965 0.5331185001780652 4.255272653658259 0.2592912805087914 0.7208839438003873 2.2904147175776397e-07 6.6400858743201026 -0.949587492240731 INALK(ub)QLQVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INALKQLQVR 10 1 Q99733;Q99733-2;C9J6D1;C9JZI7;E9PKT8;E9PNW0;E9PJJ2;E9PS34;E9PNJ7;E9PKI2;A8MXH2;C9J1B1 Q99733 NAP1L4 Nucleosome assembly protein 1-like 4 1 3394620.0 725430.0 845990.0 1823200.0 True False 993641.0750086238 808611.3644851806 1392597.7099826557 1.0 0.8137861696973051 1.4015098057118556 19.922365287172354 -6.821497527588695 1.365338529050243 0.8997807928966635 1.414762032287633 0.8878036229200721 0.08214650579711812 0.19154136560489754 0.7011882978534841 0.04727430411204459 0.10892091856436972 1.508351197465003e-07 6.821497527588695 0.5149812393909696 INALK(ub)QLQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INALKQLQVR 10 1 Q99733;Q99733-2;C9J6D1;C9JZI7;E9PKT8;E9PNW0;E9PJJ2;E9PS34;E9PNJ7;E9PKI2;A8MXH2;C9J1B1 Q99733 NAP1L4 Nucleosome assembly protein 1-like 4 1 8659500.0 2385300.0 4406200.0 1868000.0 True False 1983482.6367069623 4382462.9260377735 2258590.1633438617 1.0 2.209478845407828 1.1386992361544648 20.91960433759315 -6.616793694554865 2.1280354763034253 1.8042893673570448 1.1426660008021445 0.07229008722068264 0.5205361032133698 0.5940587517949111 5.107185676348823 0.20127961870432365 0.5775492976430607 2.4166085374960916e-07 6.616793694554865 -0.6616233665549003 INAVVETGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 INAVVETGR 9 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 4186440.0 827240.0 1361200.0 1998000.0 False True 1084519.6510035556 1158114.265916042 1791266.1261693253 1.0 1.0678591806468292 1.65166774480461 20.048624763550155 -6.928768016157224 0.7568285165200805 0.990704977503484 1.767848379180175 0.9962907675758435 0.017815442269724396 0.0932820586914884 0.08084860252672978 0.01611350324567411 0.053186698861708404 1.1782351745494617e-07 6.928768016157224 0.7771434016766909 INAVVETGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 INAVVETGR 9 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 10582640.0 557040.0 5614000.0 4411600.0 False True 845070.4050789076 4612137.837617799 3539645.3263270296 1.0 5.457696553918658 4.188580389342257 19.6887120156268 -9.634682166194796 6.757757755873617 0.9999999977305056 4.823138471634351 0.9236626075643204 0.5181145046023843 1.7069343380778353e-08 4.42475160131872e-09 0.5016622268828641 0.16722073731072176 2.3190912313735776e-10 9.634682166194796 3.8231384739038456 INAVVETGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INAVVETGR 9 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 4523440.0 827240.0 809800.0 2886400.0 False True 1133092.9833204222 774020.358349506 2204691.7672739914 1.0 0.6831040080058676 1.945728902859631 20.111834825073046 -6.840220432142806 1.2813699092366084 0.8314250120552348 1.9874398879477089 0.9248352249109753 0.14704693100210126 0.1685392024955074 0.5374478022692007 0.08998187557594105 0.2073132465293835 1.4447063040486058e-07 6.840220432142806 1.156014875892474 INAVVETGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INAVVETGR 9 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 6104440.0 557040.0 2738500.0 2808900.0 False True 721099.2608999766 2586100.067665031 2297709.021747858 1.0 3.586330215395614 3.1863976935438463 19.459838337719248 -9.697462455575597 14.333605459680689 1.0000000003500797 3.386363954469128 0.9793695852503679 0.16327176834688573 0.0 7.082887863551365e-18 0.15808720992833092 0.05269573664277696 2.0069545822011505e-10 9.697462455575597 2.386363954119048 INAYLALMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 INAYLALMR 9 0 M0QZD8 M0QZD8 0 82504000.0 29663000.0 14944000.0 37897000.0 False True 28721364.301705264 20911217.131930504 27970638.81436968 1.0 0.728071860106205 0.9738617748290247 24.775620944868184 -10.343353261748868 7.596278581306023 1.0000015318330429 0.8509668176277267 0.32895079227269286 0.10034331249884984 2.6032027859526408e-06 2.2508788879680606e-07 0.09715799344077658 0.032385664850944317 4.535725237558135e-11 10.343353261748868 -0.1490347142053161 INAYLALMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 INAYLALMR 9 0 M0QZD8 M0QZD8 0 16547300.0 3783200.0 3245700.0 9518400.0 False True 5739390.988967611 2666479.476230152 7637084.067937073 1.0 0.4645927558090605 1.3306436314614654 22.452466228906324 -6.739513974045373 1.6889275373013104 0.6812494766915903 1.3310533132214766 0.602585851643451 0.22495644876562831 0.318685948055202 1.7848107524314007 0.10538865467911332 0.2587072492475341 1.8217384551115523e-07 6.739513974045373 0.6498038365298863 INAYLALMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INAYLALMR 9 0 M0QZD8 M0QZD8 0 57438200.0 29663000.0 8344200.0 19431000.0 False True 24666098.793710876 8299248.138405977 23493932.261206914 1.0 0.336463751638019 0.9524786411378994 24.55602622030246 -10.777735395546642 10.054005258856524 1.0020712155089537 0.6444711963879668 0.3075395006200282 0.25148702553861163 0.011716767780059974 0.00025902289640801864 0.24435821178448272 0.08116708847485683 1.6682633328956917e-11 10.777735395546642 -0.35760001912098693 INAYLALMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INAYLALMR 9 0 M0QZD8 M0QZD8 0 17799000.0 3783200.0 10605000.0 3410800.0 False True 4897426.978020946 10014822.427455788 2790069.3977633957 1.0 2.044915109995736 0.5697010716616882 22.223592550998774 -6.71645333350547 1.772074157706299 1.6381297303450457 0.5724606872301822 0.49564069918860054 0.4399096385906297 0.3623034171620743 2.221494994152326 0.1972596166275296 0.49727367181557913 1.9210853781528126e-07 6.71645333350547 -1.0656690431148634 INEAVECLLSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 INEAVECLLSLK 12 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 8591700.0 4464900.0 1887000.0 2239800.0 False True 4323164.193462692 2640488.9405750004 1653129.1874403046 1.0 0.6107769269017904 0.3823887119393007 22.04365620005162 -9.177399952737737 0.14882953184241146 1.5350090901997047 6.325144846713528e-11 0.9998299565620469 0.003324856342106532 0.6225995058877093 0.05183288955307137 0.3234648591478983 0.17760289677358543 6.646607714030319e-10 9.177399952737737 -1.5350090901364533 INEELESQYQQSMDSK(ub)LSGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 INEELESQYQQSMDSKLSGR 20 1 E9PRZ9;E9PM92;O00193 E9PRZ9 C11orf58;SMAP Small acidic protein 1 19464100.0 2791200.0 3272900.0 13400000.0 True False 2702594.883825632 4579786.037948025 9890138.008616857 1.0 1.6945884362310173 3.6594970514474476 21.365913838911002 -6.952762963267963 0.5276386907222288 0.9684756474686165 4.474449555116029 0.9994006597949513 0.027572557688700036 0.08239486551418787 0.03151469179115515 0.03086956264095881 0.16243928053915663 1.1149028784804214e-07 6.952762963267963 3.5059739076474123 INEELESQYQQSMDSK(ub)LSGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 INEELESQYQQSMDSKLSGR 20 1 E9PRZ9;E9PM92;O00193 E9PRZ9 C11orf58;SMAP Small acidic protein 1 53756400.0 3503400.0 11990000.0 38263000.0 True False 5314913.93284763 9850290.821702411 30700301.278731324 1.0 1.8533302601242334 5.776255583179817 22.34161489896216 -6.941694797461735 0.6436028199189581 0.9569309100795191 6.889063988101917 0.9983775749433931 0.08377298886309485 0.08700188237339536 0.05115191925449399 0.08263475427676126 0.3351978114119838 1.1436817803219929e-07 6.941694797461735 5.932133078022398 INEELESQYQQSMDSK(ub)LSGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INEELESQYQQSMDSKLSGR 20 1 E9PRZ9;E9PM92;O00193 E9PRZ9 C11orf58;SMAP Small acidic protein 1 24211800.0 2791200.0 3069600.0 18351000.0 True False 2321006.4711258393 3053063.455532103 22188109.254562717 1.0 1.3154049734515252 9.559692973970916 21.146319114345278 -6.914978611165138 0.8611297077752705 0.7831481354708529 10.746933368260006 0.9926688619560535 0.33930558555180496 0.10121748433154228 0.12158601857295345 0.2848220625287868 0.8162113292487665 1.2162458988103658e-07 6.914978611165138 9.963785232789153 up INEELESQYQQSMDSK(ub)LSGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INEELESQYQQSMDSKLSGR 20 1 E9PRZ9;E9PM92;O00193 E9PRZ9 C11orf58;SMAP Small acidic protein 1 96650500.0 3503400.0 8322100.0 84825000.0 True False 4535220.36233839 7858967.819286157 69387720.37799925 1.0 1.7328745223824187 15.29974617202999 22.11274122105461 -6.918060530788635 0.8389802154031171 0.679217927568493 17.39285551414671 0.9936250525808297 0.5249723376957668 0.09932671622869566 0.11162510866735338 0.4477312206819089 1.3172902335535268 1.2076455050166812e-07 6.918060530788635 16.713637586578216 up INEILSNALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 INEILSNALK 10 0 P52272-2;P52272;A0A087X0X3;M0R019 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 19448600.0 1993900.0 8747800.0 8706900.0 False True 2614022.2089550686 7442662.338657334 7805993.51048234 1.0 2.847207002740987 2.9862001492338943 21.31783996776939 -10.433851140004496 0.5225447292729174 4.641959890483086e-23 2.978237299404451 0.999633088083096 0.0173414068547865 1.8145851323160982 0.24853060932607418 2.5205221704784764 0.027087975566088936 3.6825517619025885e-11 10.433851140004496 2.978237299404451 INEILSNALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 INEILSNALK 10 0 P52272-2;P52272;A0A087X0X3;M0R019 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 20030100.0 7723600.0 3231500.0 9075000.0 False True 7478418.545684896 4521854.802049877 6697985.255835679 1.0 0.6046538816230099 0.8956419348446961 22.834301786292688 -10.039039145618505 6.671949757260719 1.0000000968724874 0.7501479082338524 0.49571407136670587 0.11879537527316351 1.7124362277081015e-07 2.4661761191876768e-08 0.11502317207304016 0.03834104250328485 9.140308505648486e-11 10.039039145618505 -0.249852188638635 INEILSNALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INEILSNALK 10 0 P52272-2;P52272;A0A087X0X3;M0R019 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 25210900.0 1993900.0 12337000.0 10880000.0 False True 2731098.7131214538 11791910.546996636 8310368.080633677 1.0 4.317643478188056 3.04286624306432 21.381050029292282 -9.85998809145151 12.895465211273724 1.000000000306385 3.680254860626188 0.8549498112696009 0.5204256269615152 0.0 3.826420009384239e-18 0.5038999465403755 0.16796664884679177 1.3804221158743367e-10 9.85998809145151 2.6802548603198026 INEILSNALK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 INEILSNALKR 11 1 P52272-2;P52272;A0A087X0X3;M0R019 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 54026640.0 14897600.0 12344000.0 26785040.0 True False 19530897.86856363 10502323.316535143 24013581.001046255 1.0 0.5377286485860632 1.2295175143841095 24.219254938103365 -6.7266198875533965 1.7355595453145964 0.7207617152745883 1.2288568662326949 0.5434948346056514 0.1943854151934214 0.342626496113576 2.020270072578532 0.08881471544975557 0.22123566546952284 1.8766362989871867e-07 6.7266198875533965 0.5080951509581065 INEILSNALK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 INEILSNALKR 11 1 P52272-2;P52272;A0A087X0X3;M0R019 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 88543010.0 18894400.0 26798700.0 42849910.0 True False 18294607.614271656 37499560.66337428 31626233.101254657 1.0 2.0497603148438563 1.7287188535589568 24.124915137061798 -10.183978246046415 4.6255300675659985 0.9998610537147671 1.8892395841350125 0.9109487756107187 0.13106462790644097 0.00020202290037010486 3.5640350748660237e-05 0.12692377722551634 0.04230092673804771 6.546689658300337e-11 10.183978246046415 0.8893785304202454 INEILSNALK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INEILSNALKR 11 1 P52272-2;P52272;A0A087X0X3;M0R019 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 26048600.0 14897600.0 11151000.0 0.0 True False 20405645.31250221 10658311.948574148 0.0 1.0 0.5223217293718211 0.0 24.282464999626256 -7.861350455510313 0.6069859400102102 1.0072689136078727 6.205345574447531e-18 0.9884876252135313 0.04381784794365398 0.11452133625811675 0.1585446933089944 0.04396612676230154 0.07755308955414043 1.376098572989539e-08 7.861350455510313 -1.0072689136078727 down INEILSNALK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INEILSNALKR 11 1 P52272-2;P52272;A0A087X0X3;M0R019 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 47913500.0 18894400.0 21310500.0 7708600.0 True False 15711530.763843538 21195696.106696952 9320432.61946065 1.0 1.3490535343299557 0.5932224402290243 23.905320412496074 -6.781104951963735 1.5313265564069798 1.1973553787810782 0.5869996280902564 0.7713757582867655 0.1476835207167449 0.24885146958401785 1.1526471173500352 0.07595043496171656 0.17906425685261626 1.655369877075092e-07 6.781104951963735 -0.6103557506908218 INEK(ub)PQVIADYESGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 INEKPQVIADYESGR 15 1 O60869;O60869-2;O60869-3 O60869 EDF1 Endothelial differentiation-related factor 1 1 17158900.0 8095100.0 6437100.0 2626700.0 True False 7838125.481533708 9007467.599033028 1938688.4706891007 1.0 1.1491864502876663 0.24734083107709473 22.902077238734993 -6.864422732785772 1.1632883208670384 1.0820962291634437 0.19985389267994091 0.9587874276379779 0.08012714782756207 0.14230924112644627 0.3634736872230523 0.0536209536122104 0.1258496651096792 1.3663981558861932e-07 6.864422732785772 -0.8822423364835028 down INEK(ub)PQVIADYESGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INEKPQVIADYESGR 15 1 O60869;O60869-2;O60869-3 O60869 EDF1 Endothelial differentiation-related factor 1 1 15679700.0 8095100.0 5893300.0 1691300.0 True False 6731434.323735596 5861551.623171546 2044943.0103123526 1.0 0.8707730538948034 0.3037900857328005 22.68248251416927 -6.94275677430731 0.6333998093563378 1.0061877038917741 0.13763967718099737 0.9985031244444624 0.01169874146629653 0.08653124188201931 0.049049715507104207 0.0116415082119067 0.04823775247217459 1.140888560863081e-07 6.94275677430731 -0.8685480267107768 down INEKPQVIADYESGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 INEKPQVIADYESGR 15 1 O60869;O60869-2;O60869-3 O60869 EDF1 Endothelial differentiation-related factor 1 0 14537720.0 920220.0 7748400.0 5869100.0 False True 1206417.3314231564 6592368.9230266465 5261821.8323825775 1.0 5.464418283223703 4.361527056458516 20.202297628987218 -9.731333891235758 6.972082995628057 0.9999999944123048 4.912972669841485 0.9437686457107717 0.450253457895837 3.87184938689696e-08 7.454015204844539e-09 0.4359560489926157 0.14531867866670548 1.85637669981707e-10 9.731333891235758 3.9129726754291805 INEKPQVIADYESGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 INEKPQVIADYESGR 15 1 O60869;O60869-2;O60869-3 O60869 EDF1 Endothelial differentiation-related factor 1 0 18180500.0 4454700.0 1683800.0 12042000.0 False True 4313287.986879502 2356150.120901001 8887838.947743615 1.0 0.546253838850576 2.0605716508564558 22.040356613560842 -6.826389031207227 1.3440402685953092 0.7568816019995785 2.0983750753910315 0.8984419953213824 0.20221869592113903 0.18531121493020503 0.6559604330934049 0.11817572274059762 0.27202109779971495 1.491457796739968e-07 6.826389031207227 1.341493473391453 up INEKPQVIADYESGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INEKPQVIADYESGR 15 1 O60869;O60869-2;O60869-3 O60869 EDF1 Endothelial differentiation-related factor 1 0 26219220.0 920220.0 10387000.0 14912000.0 False True 1260450.202010443 9928067.994784294 11390092.722280279 1.0 7.876604707547215 9.036527348809859 20.26550769051011 -9.411818042517906 0.5574779728352295 2.6623067648815503e-14 8.965332380039836 0.998329338701178 0.14497141810537378 0.7526101462688449 0.2434488208161291 1.9448380103292948 0.2125158714335021 3.874199292524609e-10 9.411818042517906 8.96533238003981 INELLK(ub)YIEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 INELLKYIEER 11 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 30223600.0 10382000.0 11529000.0 8312600.0 True False 13610902.539431022 9808918.139690015 7452491.892089665 1.0 0.7206662534885845 0.5475384068396395 23.69825939938479 -9.493677390401112 0.0942709415814812 1.7208732319532225 3.839577527742489e-14 0.9999590594115221 0.0011926965835671126 0.9608087945260873 0.037129186007092196 0.421167450061464 0.2493790532367251 3.208651941793606e-10 9.493677390401112 -1.720873231953184 INELLK(ub)YIEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 INELLKYIEER 11 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 41174200.0 23214000.0 10282000.0 7678200.0 True False 22477084.27670116 14387656.219921647 5667049.0789374625 1.0 0.640103317797109 0.25212563200698135 24.421951565768364 -7.4402812895508506 0.3369417437093252 1.062174892841616 4.3904885757936465e-20 0.999588295533636 0.006196517030559961 0.11817311010010693 0.03319439060641167 0.018028742155766393 0.061150367659279115 3.628429677499481e-08 7.4402812895508506 -1.062174892841616 down INELLK(ub)YIEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 INELLKYIEER 11 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 48424900.0 27951000.0 8516900.0 11957000.0 True False 42403710.49181479 6996992.652156582 9593693.709060717 1.0 0.16500897140846235 0.22624656186426403 25.337687176026535 -10.185917869513547 7.73984948674763 1.0000004023313827 0.1956277666364162 0.9956718772018398 0.02500014161570721 1.7357113257422641e-07 1.826847142923725e-08 0.024206295295217173 0.00806876101087175 6.517516367453625e-11 10.185917869513547 -0.8043726356949664 INELLK(ub)YIEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INELLKYIEER 11 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 28131900.0 10382000.0 10332000.0 7417900.0 True False 14220505.963000612 9875498.07664499 5665944.796446008 1.0 0.6944547614789088 0.3984348244139732 23.76146946090768 -7.10480476637142 0.23304017021410345 1.1235874964065629 6.62006000703598e-12 0.999986375001003 0.0009065351354068841 0.0770036382709483 0.008928923088893786 0.00904169633690249 0.031042752096759215 7.855887103966077e-08 7.10480476637142 -1.1235874963999428 down INELLK(ub)YIEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INELLKYIEER 11 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 46457900.0 23214000.0 16808000.0 6435900.0 True False 19303469.55456982 16717451.967873236 7781616.933760569 1.0 0.8660335345733543 0.40312011847209 24.20235684120264 -6.948237810885732 0.5778650496614102 1.0055787856365281 0.24076220645072677 0.9990556484659224 0.007858130507978706 0.08420113766433765 0.03895087824806839 0.008252409524860551 0.03864755824535275 1.1265803945780558e-07 6.948237810885732 -0.7648165791858014 down INELLK(ub)YIEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INELLKYIEER 11 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 44039200.0 27951000.0 12508000.0 3580200.0 True False 36183120.49658053 11811918.804584341 2928640.3359541763 1.0 0.3264483174053664 0.08093940754034594 25.108813498118984 -9.53330706794665 0.30827886881826816 1.352440742665537 5.301783058615976e-17 0.9985869256892587 0.014605284883867612 0.9298409362843314 0.12837341958458037 0.41404459646016456 0.08246270304369563 2.9288216893902415e-10 9.53330706794665 -1.352440742665537 INELTGIK(ub)ESDTGLAPPALWDLAADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 INELTGIKESDTGLAPPALWDLAADK 26 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 17863100.0 4130600.0 6076400.0 7656100.0 True False 3999476.3639761265 8502738.208007382 5650737.731923251 1.0 2.125962859686533 1.4128693903082612 21.931379695187523 -10.155014965370661 4.797623919248145 0.999945221583158 1.7694161249947604 0.6081925383540031 0.2911191899284457 0.00021162683849548544 3.7272598811215265e-05 0.28189967282212613 0.09395831451250115 6.998178805348629e-11 10.155014965370661 0.7694709034116024 INELTGIK(ub)ESDTGLAPPALWDLAADK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INELTGIKESDTGLAPPALWDLAADK 26 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 13988700.0 4130600.0 5721500.0 4136600.0 True False 3434776.9166066214 5690677.143871165 5001543.934522592 1.0 1.6567821672370078 1.4561481155707354 21.7117849706218 -10.347768148653703 5.21392570312633 0.9997788181175907 1.556465141403909 0.9111635934035415 0.08190850860172451 0.00021067589764153246 2.6354147353037614e-05 0.07933852713244896 0.026435857477245063 4.4898501996284217e-11 10.347768148653703 0.5566863232863183 INFAVFPSLQGGPHNHAIAAVAVALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 INFAVFPSLQGGPHNHAIAAVAVALK 26 0 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 279579300.0 200704000.0 28397300.0 50478000.0 False True 194332761.37981534 39736489.979963146 37256297.49245987 1.0 0.20447653652334935 0.1917139304146663 27.5339538957192 INFAVFPSLQGGPHNHAIAAVAVALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 INFAVFPSLQGGPHNHAIAAVAVALK 26 0 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 3560159600.0 1366967600.0 975650000.0 1217542000.0 False True 2073789787.9178202 801537634.7117568 976894290.0323833 1.0 0.38650862270690284 0.47106717166990675 30.949622515110047 -10.70109034039507 6.815924427338394 1.0052414535592242 0.4287878971890707 0.9838303091863257 0.034520883058251205 0.0027560980911913884 0.00012086743833438088 0.03350440697140624 0.011141567098415059 1.9902592892581794e-11 10.70109034039507 -0.5764535563701536 INFAVFPSLQGGPHNHAIAAVAVALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INFAVFPSLQGGPHNHAIAAVAVALK 26 0 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 323717200.0 200704000.0 54144000.0 68869200.0 False True 166894268.69476974 53852315.52525746 83269431.30479711 1.0 0.3226732466394463 0.49893523579942245 27.314359171153477 -10.720878194295421 10.349636399188155 1.0007611152292244 0.4108042412215791 0.9371007236004296 0.07195865574832022 0.0012649647921341186 3.411498256294097e-05 0.06974071867448621 0.02322455627739306 1.901611546324146e-11 10.720878194295421 -0.5899568740076453 INFAVFPSLQGGPHNHAIAAVAVALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INFAVFPSLQGGPHNHAIAAVAVALK 26 0 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 2745962600.0 1366967600.0 825350000.0 553645000.0 False True 1769566505.1598005 779418546.9590414 452887290.87742305 1.0 0.4404573349949659 0.25593120662991137 30.720748837202496 -13.99999999999996 0.15505370970056004 3.728842212985814 0.06425549992650446 0.9995502576260438 0.006709172424431782 11.98032431553907 0.12425061817259833 9.838132280146912 0.17367495247752218 1.000000000000094e-14 13.99999999999996 -3.6645867130593097 INFVIDNNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 INFVIDNNK 9 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0;E9PNG3;E9PJK7 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 12099200.0 4221300.0 1211100.0 6666800.0 False True 5534165.179127345 1030408.600830825 5976983.488461295 1.0 0.18619043116333311 1.0800153763035631 22.399934274267977 -12.18045828319265 19.11729052346676 0.9554456789678362 0.6697926135656175 0.0 0.41279159550085753 0.0 0.0 0.0 0.12042580525951767 6.599966281840952e-13 12.18045828319265 -0.2856530654022187 INGQPISPELFTK(ub)YFWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 INGQPISPELFTKYFWR 17 1 Q05932-3;Q05932-2;Q05932-4;Q05932;Q5JU21;Q5JU20;Q5JU23 Q05932-3 FPGS Folylpolyglutamate synthase, mitochondrial 1 5115700.0 2059500.0 1612600.0 1443600.0 True False 1994122.2998133032 2256519.589597907 1065477.8529283067 1.0 1.1315853545237273 0.5343091810507613 20.927322462472247 -6.848939497969222 1.2401369242409672 1.0701628595291706 0.5109088957350941 0.9387535603797978 0.06341384002448662 0.1586301585375711 0.4699930713918569 0.04002253561587873 0.09255738232605439 1.4159910294485643e-07 6.848939497969222 -0.5592539637940764 INGQPISPELFTK(ub)YFWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 INGQPISPELFTKYFWR 17 1 Q05932-3;Q05932-2;Q05932-4;Q05932;Q5JU21;Q5JU20;Q5JU23 Q05932-3 FPGS Folylpolyglutamate synthase, mitochondrial 1 33563600.0 10943000.0 9090600.0 13530000.0 True False 16601331.040461155 7468311.404818017 10855789.569590336 1.0 0.44986220602529237 0.653910794449695 23.98479558099394 -10.121888202686169 5.215014915982902 1.0000118038017485 0.551886500237045 0.8654203208806351 0.08330248739739944 1.1432727666991653e-05 1.9250743884929726e-06 0.0806594092995028 0.026885762198755315 7.552866306630918e-11 10.121888202686169 -0.4481253035647035 INGQPISPELFTK(ub)YFWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INGQPISPELFTKYFWR 17 1 Q05932-3;Q05932-2;Q05932-4;Q05932;Q5JU21;Q5JU20;Q5JU23 Q05932-3 FPGS Folylpolyglutamate synthase, mitochondrial 1 7603100.0 2059500.0 2740900.0 2802700.0 True False 1712565.501319744 2726134.227673945 3388731.611779354 1.0 1.5918423123513354 1.978745694204348 20.707727737906524 -8.463695696147122 0.11765004393481697 1.4269713589799522e-10 2.9896565933721235 0.9999612901553926 0.0025041155205168595 0.13802008262443505 0.028474534971071764 0.3543784082754475 0.32167652918419903 3.4379875833400035e-09 8.463695696147122 2.9896565932294266 INGQPISPELFTK(ub)YFWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INGQPISPELFTKYFWR 17 1 Q05932-3;Q05932-2;Q05932-4;Q05932;Q5JU21;Q5JU20;Q5JU23 Q05932-3 FPGS Folylpolyglutamate synthase, mitochondrial 1 29192200.0 10943000.0 5924200.0 12325000.0 True False 14165929.218778616 5594513.06220967 10081976.465179386 1.0 0.3949273623924 0.711705974911588 23.75592190308639 -10.583081150371026 6.584302819227356 1.000803303740896 0.5533166686520359 0.7261101292040764 0.129324327016473 0.0015275216800595686 9.672275630752602e-05 0.12542427403571157 0.04173924706619014 2.611673302930617e-11 10.583081150371026 -0.4474866350888602 INHLEYEDQYK(ub)DDNFGEGNDGGILDDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 INHLEYEDQYKDDNFGEGNDGGILDDK 27 1 O60216 O60216 RAD21 Double-strand-break repair protein rad21 homolog 1 18910100.0 6491100.0 7619600.0 4799400.0 True False 6285043.5835485 10662146.015689077 3542293.161086256 1.0 1.696431516178809 0.5636067775820096 22.583491318353612 -6.7403881981421545 1.685506377801008 1.414190766902364 0.5629152390438482 0.6066004157785756 0.29260716287111366 0.31710662420859265 1.7690722125168226 0.13733495390928008 0.3368339930152146 1.8180750288954432e-07 6.7403881981421545 -0.8512755278585157 INHLEYEDQYK(ub)DDNFGEGNDGGILDDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INHLEYEDQYKDDNFGEGNDGGILDDK 27 1 O60216 O60216 RAD21 Double-strand-break repair protein rad21 homolog 1 17857200.0 6491100.0 8349100.0 3017000.0 True False 5397637.254487299 8304121.741133396 3647840.750968109 1.0 1.5384734745243958 0.6758217677439318 22.36389659378789 -6.737903487690209 1.6942260222540242 1.3211610166789352 0.6755274128092604 0.5955695736697755 0.2262575892825663 0.3216151091230939 1.8117873786193617 0.10568073062811492 0.25994486820232626 1.8285065159864745e-07 6.737903487690209 -0.6456336038696747 INILSGETVK(ub)AGDRDPLGNDCPEQDRLPQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 INILSGETVKAGDRDPLGNDCPEQDRLPQR 30 3 Q9Y5Z9;Q9Y5Z9-2 Q9Y5Z9 UBIAD1 UbiA prenyltransferase domain-containing protein 1 1 63312500.0 3978500.0 25165000.0 34169000.0 True False 6035675.367310122 20674109.134957578 27415482.173195247 1.0 3.4253182745597646 4.542239352646516 22.525083780992826 -8.988601843997708 0.2978494294516057 1.1936629829446466e-19 5.059097138687043 0.9986596661925303 0.05413351508196545 0.45706852915387286 0.10268655741747695 0.8948322694682639 0.38330267712446264 1.0265926628692392e-09 8.988601843997708 5.059097138687043 INILSGETVK(ub)AGDRDPLGNDCPEQDRLPQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INILSGETVKAGDRDPLGNDCPEQDRLPQR 30 3 Q9Y5Z9;Q9Y5Z9-2 Q9Y5Z9 UBIAD1 UbiA prenyltransferase domain-containing protein 1 1 44916500.0 3978500.0 10051000.0 30887000.0 True False 5150246.677959489 9491653.014460918 25265882.927382976 1.0 1.8429511454432859 4.905761705649648 22.296210103085276 -6.9470848644579295 0.5899805655177746 0.9645965758826209 5.938227484998974 0.9989522072487719 0.05432179953953145 0.08467786722218648 0.040972805590196865 0.05631851625019828 0.2565857335493227 1.1295751654929678e-07 6.9470848644579295 4.973630909116353 INISEGNCPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 INISEGNCPER 11 0 Q15365;F8VTZ0;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;F8VXH9;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 0 44785610.0 733610.0 27289000.0 16763000.0 False True 961769.8142893453 23217587.57168884 15028525.56205027 1.0 24.140482708790756 15.625906884127877 19.87533212152955 -9.132096047379356 11.519911132955558 1.0000000000017983 19.883194796481455 0.8676878126823958 3.476061024444258 0.0 0.0 3.3656816145180097 1.121893871506003 7.377410552928409e-10 9.132096047379356 18.883194796479657 INISEGNCPER ddPTM_RPMI8226_Bortezomib_2h_R1 1 INISEGNCPER 11 0 Q15365;F8VTZ0;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;F8VXH9;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 0 24184400.0 9337700.0 2593700.0 12253000.0 False True 9041279.824698556 3629377.935966817 9043571.717879297 1.0 0.40142302929860085 1.0002534921189454 23.10809557493562 -10.88975882323346 10.599686458540786 1.0202947703323748 0.7008382607087732 0.24968251595484936 0.24447151272408954 0.1005563832607399 0.0010458265508200256 0.20300935118716695 0.07890284145021108 1.2889651540313294e-11 10.88975882323346 -0.3194565096236016 INISEGNCPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INISEGNCPER 11 0 Q15365;F8VTZ0;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;F8VXH9;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 0 42079610.0 733610.0 21952000.0 19394000.0 False True 1004845.4420648112 20982088.05444352 14813536.631967785 1.0 20.88091081084906 14.742104618127263 19.93854218305244 -9.602972718527914 8.374685939605541 1.0000127693722312 17.811507714488233 0.9090879061603157 2.506157133678751 0.0 0.0 2.4265759573157997 0.8088587368080543 2.4947514370943946e-10 9.602972718527914 16.811494945116003 INK(ub)ELSDLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 INKELSDLAR 10 1 P61077;P61077-2;D6RA11;D6RIZ3;D6R980;D6R9F6;D6R933;D6RGD0 P61077 UBE2D3 Ubiquitin-conjugating enzyme E2 D3 1 10618380.0 4809380.0 4639000.0 1170000.0 True False 6305143.754102165 3946879.2826803667 1048939.6234324882 1.0 0.6259776837145867 0.16636252309870678 22.588097832973 -7.51622770579406 0.43027900284314496 1.0293953586845235 2.0235228852005218e-25 0.9984374621149381 0.013476544722487233 0.1183992297843001 0.055526505807658014 0.020153844205295614 0.06784769398200066 3.046297360675376e-08 7.51622770579406 -1.0293953586845235 down INK(ub)ELSDLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 INKELSDLAR 10 1 P61077;P61077-2;D6RA11;D6RIZ3;D6R980;D6R9F6;D6R933;D6RGD0 P61077 UBE2D3 Ubiquitin-conjugating enzyme E2 D3 1 8755320.0 4131100.0 2675620.0 1948600.0 True False 3999960.4917498184 3744009.0191739765 1438203.2032530466 1.0 0.9360114998376212 0.3595543521540863 21.93155431966465 -6.927956714382886 0.7633812853064752 1.009462840639508 0.24714315001182507 0.9961211210877775 0.01793769020639115 0.0937128629362644 0.08298130228829846 0.016147677437004706 0.05275766546922464 1.1804382826755928e-07 6.927956714382886 -0.762319690627683 down INK(ub)ELSDLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INKELSDLAR 10 1 P61077;P61077-2;D6RA11;D6RIZ3;D6R980;D6R9F6;D6R933;D6RGD0 P61077 UBE2D3 Ubiquitin-conjugating enzyme E2 D3 1 9128480.0 4809380.0 2973100.0 1346000.0 True False 6587537.754607569 2841738.6112730545 1028102.521740158 1.0 0.4313809980497549 0.1560677995387677 22.65130789449589 -9.107749754400311 0.26506549648660455 1.3142753255002007 7.725557232845341e-10 0.9989880586383239 0.011178437459206731 0.549168102174609 0.09388774793292257 0.2665261589417755 0.10658253161848184 7.802795873096106e-10 9.107749754400311 -1.3142753247276449 INK(ub)ELSDLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INKELSDLAR 10 1 P61077;P61077-2;D6RA11;D6RIZ3;D6R980;D6R9F6;D6R933;D6RGD0 P61077 UBE2D3 Ubiquitin-conjugating enzyme E2 D3 1 8486020.0 4131100.0 2448400.0 1906520.0 True False 3435192.6887603817 2435209.9832306504 2305164.5172475018 1.0 0.7089005490720861 0.6710437306151056 21.711959595098925 -13.999999999999844 0.28755380519531554 3.4741486244605437 0.660470978876036 0.999621989691787 0.0028573288363632683 15.821886612071404 0.17000100553447925 23.123808216735082 0.014457308358182368 1.0000000000003599e-14 13.999999999999844 -2.813677645584508 INK(ub)ELSDLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INKELSDLAR 10 1 P61077;P61077-2;D6RA11;D6RIZ3;D6R980;D6R9F6;D6R933;D6RGD0 P61077 UBE2D3 Ubiquitin-conjugating enzyme E2 D3 1 36633900.0 6637300.0 7056400.0 22940200.0 True False 8592115.690742873 6663705.136925886 18765318.98632924 1.0 0.7755604529516925 2.184016098217457 23.034581988315253 -6.866114016442043 1.1545209151424738 0.8756189890925887 2.2606097810557078 0.9606448952611982 0.1225763760328843 0.14063165114584555 0.35279823535557386 0.08257982488515811 0.19428746345919484 1.3610873058219856e-07 6.866114016442043 1.384990791963119 up INK(ub)MLSCAGADR ddPTM_RPMI8226_Bortezomib_1h_R1 1 INKMLSCAGADR 12 1 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 22739200.0 5691500.0 4273700.0 12774000.0 True False 7461611.616564404 3636080.618752127 11452269.016860338 1.0 0.48730499597167587 1.534825129659238 22.831055837889643 -6.773623200387987 1.5605737688748877 0.7072904997099932 1.5415410863151304 0.7442079606977319 0.21630301296814514 0.26062246985052206 1.25310136151108 0.10921925182662061 0.25913394069612794 1.6841346047479557e-07 6.773623200387987 0.8342505866051372 INK(ub)MLSCAGADR ddPTM_RPMI8226_Bortezomib_2h_R1 1 INKMLSCAGADR 12 1 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 23095600.0 6290000.0 4963600.0 11842000.0 True False 6090327.392971928 6945591.364832046 8740224.947615 1.0 1.140429884417555 1.4350993606190992 22.538088353370643 -6.95909530079433 0.4480028295833022 0.9903011416555533 1.5968708287860987 0.9997351560107737 0.002950649656536169 0.08002589731572601 0.022337551009483377 0.003927047729335149 0.02438144380287039 1.0987647020404457e-07 6.95909530079433 0.6065696871305454 INK(ub)MLSCAGADR ddPTM_RPMI8226_Bortezomib_8h_R1 1 INKMLSCAGADR 12 1 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 60251200.0 6966500.0 14807000.0 38477700.0 True False 10568689.819370624 12164575.162380973 30872565.729624987 1.0 1.151001247106842 2.921134620966999 23.333293203822052 -6.923733974808189 0.7965449091139908 0.9659455150459211 3.232628988687381 0.9951568620002946 0.060700206055813735 0.09602411935150003 0.09459273110288413 0.05336178983348562 0.16602479685852822 1.1919719216566805e-07 6.923733974808189 2.26668347364146 up INK(ub)MLSCAGADR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INKMLSCAGADR 12 1 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 37289300.0 5691500.0 5371800.0 26226000.0 True False 7795801.3570042355 5134456.1138329 20031958.94142453 1.0 0.6586181302862192 2.569583038878558 22.894265899412535 -6.86070568621319 1.1820423903249144 0.8144001684687026 2.6634300651354503 0.9545003083691077 0.17749817204584042 0.1460832577040277 0.38743047794856883 0.11707823470734639 0.27353861946748304 1.37814309601809e-07 6.86070568621319 1.8490298966667478 up INK(ub)MLSCAGADR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INKMLSCAGADR 12 1 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 24296400.0 6290000.0 5840700.0 12165700.0 True False 5230413.694246757 5809234.989811828 14709491.622158673 1.0 1.1106645342799082 2.8122998451037473 22.31849362880492 -6.92012528753744 0.8237967984834076 0.9626237542382897 3.087496397937074 0.9942156424831025 0.0630855946432141 0.09809819011512928 0.10523268340368018 0.054390720991784054 0.16312177310930306 1.201917649125896e-07 6.92012528753744 2.1248726436987844 up INK(ub)MLSCAGADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INKMLSCAGADR 12 1 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 49556300.0 6966500.0 17903300.0 24686500.0 True False 9018271.580245025 16906965.61673445 20193810.304880403 1.0 1.8747456723048797 2.2392107096348655 23.1044195259145 -10.10188010126454 0.2069271104859851 2.2446606120390764e-18 2.539787645834847 0.9993651656287714 0.013102032949741932 1.6427767345226851 0.09693235089797118 1.1202535994138048 0.2103378238878705 7.908969463507337e-11 10.10188010126454 2.539787645834847 INK(ub)NCWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 INKNCWR 7 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 8464300.0 3251900.0 1615600.0 3596800.0 True False 4933370.04573477 1327283.5572595866 2885890.903466559 1.0 0.2690419621790002 0.5849735326385268 22.234142075412663 -10.51860646149719 6.294353990419017 1.0005346719613089 0.4270077474106033 0.8143270358285796 0.12897852354366524 0.0009685825549272293 7.407731352984442e-05 0.12499190617234768 0.041627639475253025 3.0296575266357206e-11 10.51860646149719 -0.5735269245507055 INK(ub)NCWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INKNCWR 7 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 3901080.0 1632000.0 1486400.0 782680.0 True False 1357080.3098586174 1478392.4681726994 946334.7692965594 1.0 1.0893920259787135 0.6973314419359234 20.372074669009763 -6.846756994612223 1.250638265456139 1.047601436455471 0.6826118196137505 0.9354533300418262 0.04262284383194311 0.16105944199721908 0.486400297995542 0.026689161606541285 0.06164583624838661 1.4231248604990821e-07 6.846756994612223 -0.3649896168417206 INK(ub)NCWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INKNCWR 7 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 7423000.0 3251900.0 1110200.0 3060900.0 True False 4209648.654532226 1048416.3940557675 2503847.607486212 1.0 0.2490508068712606 0.5947877870497577 22.005268397505112 -10.607557868788827 6.539573395209827 1.0015688605840665 0.4219192969650351 0.7884741504790257 0.14114653110800993 0.003235488529545741 0.00019416252733012407 0.13695878344634985 0.04555484702968912 2.4685511539543173e-11 10.607557868788827 -0.5796495636190313 INK(ub)SESVVYADIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 INKSESVVYADIR 13 1 O95297-4;O95297-2;O95297;O95297-5 O95297-4 MPZL1 Myelin protein zero-like protein 1 1 20156700.0 5539200.0 9307900.0 5309600.0 True False 7261944.841689096 7919197.601910034 4760213.525279602 1.0 1.0905064379514158 0.6555011954858635 22.791924541472234 -6.85243556795179 1.2234033008931262 1.0484153501919822 0.6372898563999082 0.9437527804091399 0.04444693274554776 0.15480585461906501 0.44466499382802877 0.02841067893172677 0.0658495564902 1.4046380606072762e-07 6.85243556795179 -0.41112549379207397 INLNHLLNFTFEPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 INLNHLLNFTFEPR 14 0 Q8N5U6;Q8N5U6-2;F5H5P6 Q8N5U6 RNF10 RING finger protein 10 0 5253400.0 1994500.0 1745000.0 1513900.0 False True 2614808.8147654748 1484652.801956727 1357256.150354227 1.0 0.5677863687674187 0.5190651579151728 21.318274035080123 -13.999999999999998 0.3081368958396465 5.132703661636283 0.5080586367342366 0.9996678930449552 0.0039390391610424095 17.138195288356435 0.1765548832269743 45.364550496948986 0.01701358842800908 1.0000000000000041e-14 13.999999999999998 -4.624645024902046 INLNHLLNFTFEPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 INLNHLLNFTFEPR 14 0 Q8N5U6;Q8N5U6-2;F5H5P6 Q8N5U6 RNF10 RING finger protein 10 0 27323200.0 11072000.0 5609200.0 10642000.0 False True 10720525.42050638 7848982.811591568 7854540.946843343 1.0 0.732145347706365 0.7326638050611829 23.353872279240715 -9.97503022424095 5.071420223686838 1.0000016960015017 0.7324045763807462 0.9999971825785506 0.00021165933930722172 4.058938651008905e-09 8.201554930901596e-10 0.00020493957037361678 6.831275650807829e-05 1.0591800101586842e-10 9.97503022424095 -0.2675971196207555 INLNHLLNFTFEPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 INLNHLLNFTFEPR 14 0 Q8N5U6;Q8N5U6-2;F5H5P6 Q8N5U6 RNF10 RING finger protein 10 0 28533000.0 12672000.0 8253400.0 7607600.0 False True 19224350.447292686 6780516.285891477 6103954.525470473 1.0 0.3527045714486733 0.3175116133159171 24.196431517415494 -13.681126389212588 0.4174928713118648 9.999794667320554 0.3162285436459998 0.9998562142036949 0.003762340235756115 22.3301465199664 0.21478205558646749 181.40002706900518 0.008597406376734555 2.0838843388280126e-14 13.681126389212588 -9.683566123674554 INLNHLLNFTFEPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INLNHLLNFTFEPR 14 0 Q8N5U6;Q8N5U6-2;F5H5P6 Q8N5U6 RNF10 RING finger protein 10 0 10288500.0 1994500.0 1658300.0 6635700.0 False True 2731920.5493358416 1585030.8227352293 5068484.326531334 1.0 0.5801892090604783 1.8552824780221135 21.381484096603014 -6.818002041831573 1.3805782376901803 0.7732601461190439 1.8819259070904377 0.8797096590445067 0.1840196422237056 0.19609010743963726 0.7349397735134137 0.10476051159401589 0.24158468794431537 1.520540380908863e-07 6.818002041831573 1.1086657609713937 INLNHLLNFTFEPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INLNHLLNFTFEPR 14 0 Q8N5U6;Q8N5U6-2;F5H5P6 Q8N5U6 RNF10 RING finger protein 10 0 23200400.0 11072000.0 4254500.0 7873900.0 False True 9206858.572766304 4231580.164047873 9520296.085199803 1.0 0.45961172647582516 1.034043915191729 23.13427755467499 -11.773700194865171 13.81031751555068 0.9120165920277826 0.7721450387501728 0.0 0.269682514652179 0.0 0.0 0.0 0.0782129150983034 1.6838360571605336e-12 11.773700194865171 -0.1398715532776098 INLNHLLNFTFEPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INLNHLLNFTFEPR 14 0 Q8N5U6;Q8N5U6-2;F5H5P6 Q8N5U6 RNF10 RING finger protein 10 0 25100600.0 12672000.0 8265600.0 4163000.0 False True 16404153.802463923 7805612.093953643 3405376.71598716 1.0 0.4758314380581601 0.207592342585551 23.967557839507943 -9.147977058759684 0.22946190657125298 1.375107016104556 9.262839743854063e-27 0.9993216698464515 0.008570688419194816 0.5843915955947624 0.0809799016376768 0.29038235549349106 0.1235214134892721 7.112510839006213e-10 9.147977058759684 -1.375107016104556 INLNLIYDHNPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 INLNLIYDHNPK 12 0 O95163;F5H2T0 O95163 IKBKAP Elongator complex protein 1 0 23398800.0 7815300.0 5233500.0 10350000.0 False True 10245933.983472848 4452682.200023219 9279081.284210471 1.0 0.4345804108444965 0.9056354744406948 23.288548165584427 -10.124531956713454 7.540025072135605 1.0000000826648465 0.6701079426426004 0.39538380559187924 0.19230742442749424 2.671970558115147e-07 3.127866049484128e-08 0.1862009074332955 0.062066954346643895 7.507028130834125e-11 10.124531956713454 -0.3298921400222461 INLNLIYDHNPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 INLNLIYDHNPK 12 0 O95163;F5H2T0 O95163 IKBKAP Elongator complex protein 1 0 15543300.0 5373000.0 3034300.0 7136000.0 False True 5202437.056031506 4245911.8136654645 5266867.524588804 1.0 0.8161390071491432 1.0123846704656618 22.31075617431111 -13.49781861056568 12.362826025422246 8.59233233134815 0.922835654926663 0.0 0.09193754579706269 0.0 0.0 0.0 0.026683723785484118 3.178201215642991e-14 13.49781861056568 -7.6694966764214865 INLNLIYDHNPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INLNLIYDHNPK 12 0 O95163;F5H2T0 O95163 IKBKAP Elongator complex protein 1 0 22313900.0 7815300.0 7408100.0 7090500.0 False True 10704827.61054118 7080785.646689292 5415869.93343134 1.0 0.6614572325963244 0.5059278047689684 23.351758227107318 -13.999999999999998 0.104446127970625 2.652295167938781 0.19636914956462612 0.9997712863779874 0.0031194009835973733 12.048149573631553 0.097115291022943 4.24570574590836 0.2754707179251641 1.0000000000000041e-14 13.999999999999998 -2.455926018374155 INLNLIYDHNPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INLNLIYDHNPK 12 0 O95163;F5H2T0 O95163 IKBKAP Elongator complex protein 1 0 10870400.0 5373000.0 2195100.0 3302300.0 False True 4467887.564258797 2183274.560606763 3992795.661889954 1.0 0.48865924426389606 0.8936652063115069 22.091161449745385 -9.905651731248945 6.674735788757117 1.0000000153195097 0.6911622252876966 0.43671885709800917 0.16534299163363333 3.768971756542538e-08 6.0758415237546205e-09 0.1600926727945406 0.05336422108409433 1.2426484108105392e-10 9.905651731248945 -0.3088377900318131 INLWHLEITDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 INLWHLEITDR 11 0 P63151-2;P63151;A0A590UJY3;A0A590UJJ1;Q66LE6 P63151-2;Q66LE6 PPP2R2A;PPP2R2D Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform;Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform 0 14521000.0 2751200.0 7268800.0 4501000.0 False True 3606849.8426587004 6184323.373560485 4035279.696640713 1.0 1.7146051660974786 1.1187822816782986 21.78230793263239 -10.391344173829797 6.30235186639387 0.9999392069717441 1.4166937238878887 0.3947230188237607 0.24324367398337823 0.0002078081120018138 2.0069162973634497e-05 0.23555384951035 0.07850655820066081 4.061213546799114e-11 10.391344173829797 0.4167545169161446 INLWHLEITDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 INLWHLEITDR 11 0 P63151-2;P63151;A0A590UJY3;A0A590UJJ1;Q66LE6 P63151-2;Q66LE6 PPP2R2A;PPP2R2D Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform;Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform 0 18821200.0 8347000.0 4413000.0 6061200.0 False True 8082029.053916794 6175133.913490978 4473589.8878976535 1.0 0.7640573762226607 0.5535231138187529 22.946286107169023 -6.972472940627923 0.1900513966711112 1.1425926819409713 0.1692360217985825 0.9999957949285169 0.00037393195239192805 0.07550814113822318 0.006063383668403462 0.0074295137257611695 0.022947281857747654 1.0654352451478581e-07 6.972472940627923 -0.9733566601423889 INLWHLEITDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 INLWHLEITDR 11 0 P63151-2;P63151;A0A590UJY3;A0A590UJJ1;Q66LE6 P63151-2;Q66LE6 PPP2R2A;PPP2R2D Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform;Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform 0 36381900.0 7930900.0 13134000.0 15317000.0 False True 12031755.126454651 10790135.08358962 12289588.2363204 1.0 0.8968047446265728 1.0214293847535878 23.520343774517542 -6.686830601243623 1.877540461876869 0.9351112123165987 1.0209841187110358 0.35562654034672825 0.043672985825576334 0.4235558783454803 2.892280154150419 0.018625024879729845 0.04869797605752851 2.0566926629107882e-07 6.686830601243623 0.08587290639443712 INLWHLEITDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INLWHLEITDR 11 0 P63151-2;P63151;A0A590UJY3;A0A590UJJ1;Q66LE6 P63151-2;Q66LE6 PPP2R2A;PPP2R2D Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform;Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform 0 17601800.0 2751200.0 6459600.0 8391000.0 False True 3768392.988384443 6174193.512959343 6409218.618069591 1.0 1.6384155081464307 1.700782969776542 21.84551799415528 -11.383062842277571 0.39571648406119037 5.969322384223378e-11 1.7057049866038005 0.9996208338366765 0.006166398444299101 3.6544884214270112 0.19810607212462175 3.1780512135705217 0.01612589931367073 4.13939773528438e-12 11.383062842277571 1.7057049865441074 INLWHLEITDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INLWHLEITDR 11 0 P63151-2;P63151;A0A590UJY3;A0A590UJJ1;Q66LE6 P63151-2;Q66LE6 PPP2R2A;PPP2R2D Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform;Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform 0 15679000.0 8347000.0 2692100.0 4639900.0 False True 6940900.334797718 2677597.1229599915 5610081.637526326 1.0 0.3857708645571592 0.8082642549123742 22.7266913826033 -9.92230509381363 5.6118792885243245 1.0000003609045844 0.5970175597340744 0.5481306157030925 0.1724822043474801 7.787532078237817e-07 1.4944190720610826e-07 0.1670053255481496 0.055668392079188035 1.195900110971968e-10 9.92230509381363 -0.40298280117051 INLWHLEITDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INLWHLEITDR 11 0 P63151-2;P63151;A0A590UJY3;A0A590UJJ1;Q66LE6 P63151-2;Q66LE6 PPP2R2A;PPP2R2D Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform;Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform 0 27549600.0 7930900.0 12689000.0 6929700.0 False True 10266706.39141106 11982845.995472534 5668565.704726449 1.0 1.1671558081662066 0.5521308868313083 23.29147009660999 -6.834294011748931 1.3085457102400242 1.089086793264991 0.5340723792759786 0.9142096128733842 0.07605275048894172 0.17556649057196635 0.5863891691761782 0.04561116518320517 0.10497708670008407 1.4645560197796842e-07 6.834294011748931 -0.5550144139890124 INMAHLCVIGSHAVNGVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 INMAHLCVIGSHAVNGVAR 19 0 P11216 P11216 PYGB Glycogen phosphorylase, brain form 0 11159400.0 4699000.0 3360000.0 3100400.0 False True 6160434.505180727 2858701.0971774203 2779600.3491368266 1.0 0.4640421215051219 0.45120199667722666 22.554600679394074 INMAHLCVIGSHAVNGVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INMAHLCVIGSHAVNGVAR 19 0 P11216 P11216 PYGB Glycogen phosphorylase, brain form 0 12483000.0 4699000.0 3829900.0 3954100.0 False True 6436347.285700232 3660682.3542143432 3020223.017245738 1.0 0.5687515281139908 0.4692448811697639 22.617810740916966 -13.999999999999998 0.20603197884719202 3.454287015483794 0.4083303687097319 0.999488170807298 0.005211504014798883 12.656732781431508 0.14389588176070744 12.551180744597245 0.06062526463846013 1.0000000000000041e-14 13.999999999999998 -3.045956646774062 INMMLANLYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INMMLANLYK 10 0 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 0 3789800.0 1113300.0 1021200.0 1655300.0 False True 1524917.095801249 976080.0073431911 1264352.2319736127 1.0 0.6400872611571856 0.8291285050544169 20.54029938004717 -10.019603401727357 4.850513092974678 1.000004660810894 0.7346078831007777 0.7243551357800612 0.07717576466553322 3.889952345613585e-06 7.862756832490404e-07 0.07472642542599159 0.024908370937569303 9.558650847871602e-11 10.019603401727357 -0.26539677771011616 INNACFEAVVVTNTIPQEDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 INNACFEAVVVTNTIPQEDK 20 0 B1ALA9;P60891;P60891-2;B7ZB02 B1ALA9 PRPS1 Ribose-phosphate pyrophosphokinase 1 0 31866600.0 3265300.0 22874000.0 5727300.0 False True 4953698.825405993 18791955.984622285 4595296.64463523 1.0 3.793520084072157 0.9276495819784949 22.240074727714386 -6.651943261831037 2.00118500685135 2.8098213742105913 0.939543699823744 0.2022546079945402 1.1917139121526967 0.5036901434134533 3.86847570756583 0.4825447200663554 1.320465034579795 2.2287263009998776e-07 6.651943261831037 -1.8702776743868474 INNACFEAVVVTNTIPQEDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INNACFEAVVVTNTIPQEDK 20 0 B1ALA9;P60891;P60891-2;B7ZB02 B1ALA9 PRPS1 Ribose-phosphate pyrophosphokinase 1 0 14726900.0 3265300.0 5523800.0 5937800.0 False True 4226995.218685715 5216395.674189551 4857181.32697299 1.0 1.2340670865039365 1.149086070762866 22.011201049806836 -10.115930046962442 4.210544754735345 0.9999717408054701 1.1915765785231254 0.8714008041023593 0.03469335480519203 12093831.272129776 0.2809142126005929 4256.254094970387 0.011876458075178164 7.657199336488822e-11 10.115930046962442 0.19160483771765524 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQK(ub)PNYIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIK 36 1 P55735;P55735-2;P55735-4;P55735-3;A8MXL6 P55735 SEC13 Protein SEC13 homolog 1 21529500.0 11893000.0 5309100.0 4327400.0 True False 9889556.449233169 5280498.824526158 5232239.332363078 1.0 0.5339469825196868 0.5290671385741252 23.23747438628009 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQK(ub)PNYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIK 36 1 P55735;P55735-2;P55735-4;P55735-3;A8MXL6 P55735 SEC13 Protein SEC13 homolog 1 53837000.0 15772000.0 22223000.0 15842000.0 True False 20417164.91259952 20986270.514413003 12958918.552646792 1.0 1.027873879857937 0.634707052037856 24.28327921453615 -6.889880220839738 1.0231149598825116 1.0211860958623362 0.6009733119944329 0.9808206528630264 0.024807972093045177 0.11923942909925564 0.2224276096433126 0.01847858356445046 0.046046553789364106 1.288604902121817e-07 6.889880220839738 -0.4202127838679033 INNINILVCTPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 INNINILVCTPGR 13 0 Q13206;E9PIF2;A0A3B3ISR7 Q13206 DDX10 Probable ATP-dependent RNA helicase DDX10 0 10416200.0 2882900.0 2935300.0 4598000.0 False True 3779509.8180433116 2497364.6817097855 4122243.067130411 1.0 0.6607641736469135 1.0906819311464404 21.849767706168677 -6.696329390105854 1.8437750636155101 0.7885979572359415 1.0893266069486414 0.400267232758891 0.14329368388434302 0.4032045151320973 2.6621379841624857 0.06206034388497899 0.1603409343517883 2.0121975222727328e-07 6.696329390105854 0.30072864971269986 INNINILVCTPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INNINILVCTPGR 13 0 Q13206;E9PIF2;A0A3B3ISR7 Q13206 DDX10 Probable ATP-dependent RNA helicase DDX10 0 11211500.0 2882900.0 3765700.0 4562900.0 False True 3948786.037443116 3599318.9224953586 3485236.9958753115 1.0 0.9115001137985078 0.8826097344418393 21.91297776769157 -13.999999999985311 0.1565296670314696 1.4328064373194895 0.8530928103509757 0.9995459164328998 0.0010641990559600912 11.988321526259686 0.12490089120527104 1.5758983048903608 0.026789689878466454 1.000000000033822e-14 13.999999999985311 -0.5797136269685138 INNK(ub)VVQLHEYSEELEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 INNKVVQLHEYSEELEK 17 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 12147500.0 3934200.0 3883800.0 4329500.0 True False 3809310.9744722038 5434621.593749446 3195474.067784085 1.0 1.426667875153573 0.8388588091647812 21.861098636961813 -6.7120264341095135 1.7880026447002937 1.261760252196437 0.8401564687643543 0.47472517334784714 0.17973936069527188 0.371010213273183 2.3133382261821027 0.07996018389035622 0.20263723656957638 1.9407677457016127e-07 6.7120264341095135 -0.4216037834320827 INNK(ub)VVQLHEYSEELEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INNKVVQLHEYSEELEK 17 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 7909400.0 2127800.0 2450600.0 3331000.0 True False 2914505.1616328903 2342324.388949499 2544286.4040984176 1.0 0.8036782434920035 0.8729737169766916 21.47481952600567 -10.598970217294378 8.913961776117878 1.0000430403783709 0.8383259812709991 0.8789034645874552 0.028289758587007885 2.420435740250368e-05 1.0888993399200094e-06 0.027398711908477435 0.009130480322975814 2.517849588948545e-11 10.598970217294378 -0.16171705910737177 INNK(ub)VVQLHEYSEELEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INNKVVQLHEYSEELEK 17 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 10882800.0 3934200.0 4387600.0 2561000.0 True False 3271461.614611382 4363963.127929593 3096493.2592738927 1.0 1.33394905458733 0.946516763468651 21.64150391239609 -6.678721890508982 1.9073156037187655 1.2115460869712709 0.9480367927128269 0.31793738884778644 0.14157689447603025 0.4413418424208003 3.1032778113308312 0.05959831601604425 0.15739329483478087 2.0954538937159825e-07 6.678721890508982 -0.26350929425844394 INNWIVQLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 INNWIVQLSK 10 0 M0R1C6;M0QYU7;H0YD59;E9PME6;M0QXT0;B1AQP1;B4DLJ1;Q15853-4;P22415-2;Q15853-3;P22415;Q15853-2;Q15853 M0R1C6 USF2;USF1 Upstream stimulatory factor 2;Upstream stimulatory factor 1 0 7868300.0 2346200.0 2156900.0 3365200.0 False True 3075890.920633123 1835098.9275303518 3017001.3852777844 1.0 0.5966072838345731 0.9808544786291652 21.55257291168374 -10.636867085117585 9.474308916536497 1.0000766306669333 0.7887308821280997 0.28728137676683785 0.1568682603904272 0.00025400569737605774 9.735482756878863e-06 0.1519417065994382 0.05062901333672106 2.3074532717264277e-11 10.636867085117585 -0.2113457485388336 INNWIVQLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 INNWIVQLSK 10 0 M0R1C6;M0QYU7;H0YD59;E9PME6;M0QXT0;B1AQP1;B4DLJ1;Q15853-4;P22415-2;Q15853-3;P22415;Q15853-2;Q15853 M0R1C6 USF2;USF1 Upstream stimulatory factor 2;Upstream stimulatory factor 1 0 6631790.0 2428100.0 975390.0 3228300.0 False True 2351021.2945747436 1364868.3135916542 2382711.383075956 1.0 0.5805427270017703 1.013479286033836 21.164856175706962 -10.954173452049353 11.786535466399501 1.0585243039803924 0.7970110065178032 0.2266724249160127 0.1767456101041481 0.09968056484333626 0.0003875617296951023 0.0627583974017671 0.05704440037071957 1.1112878035106128e-11 10.954173452049353 -0.2615132974625892 INPELNQK(ub)GYNVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 INPELNQKGYNVK 13 1 P46734-2;P46734;P46734-3 P46734-2 MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 1 28321700.0 4299100.0 4779600.0 19243000.0 True False 6522049.006309662 3926643.0368147567 15439612.615493467 1.0 0.6020566593437098 2.3672947873523547 22.63689385078073 -6.847506673175641 1.2472320294960648 0.7880292378308751 2.434472922575788 0.9365724586353343 0.19039904646887443 0.16022406490586022 0.48091117421095664 0.11953334682911963 0.27617484450667945 1.42067038330391e-07 6.847506673175641 1.646443684744913 up INPELNQK(ub)GYNVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INPELNQKGYNVK 13 1 P46734-2;P46734;P46734-3 P46734-2 MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 1 22448400.0 4299100.0 5147300.0 13002000.0 True False 5565269.697930295 4860848.230159649 10635769.411785988 1.0 0.8734254571647052 1.911096854073648 22.40802017287318 -6.8763864259767145 1.099697324222495 0.9247339920948442 1.9797403107273048 0.97065450898173 0.07918183907116647 0.13088188168867207 0.2920064371641707 0.05563214894546624 0.13338719727323886 1.329271134492548e-07 6.8763864259767145 1.0550063186324605 INPENSK(ub)LSDLDSETR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INPENSKLSDLDSETR 16 1 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 1 31205800.0 11756000.0 4126800.0 15323000.0 True False 15218373.745404512 3897139.9522512467 12534371.227257088 1.0 0.2560812355806457 0.8236340779212423 23.859310863079667 -10.187944162550174 7.353030821326091 1.0000004918363259 0.5398576567524536 0.46706926925563474 0.23170247763345495 1.8680649628045586e-06 2.064081376365609e-07 0.22434519662477442 0.07478165309578062 6.487178341497575e-11 10.187944162550174 -0.4601428350838723 INPTSSLYK(ub)SLVSGSDKENQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 INPTSSLYKSLVSGSDKENQK 21 2 O75665;O75665-3;O75665-2 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 9149000.0 2971300.0 2118800.0 4058900.0 True False 3895403.0741101326 1802683.299017714 3638923.9637180585 1.0 0.4627719557441484 0.9341585182553505 21.893341187195954 -10.298578606594686 8.272623019786604 1.0000004750536096 0.6984652369997504 0.3529940525580534 0.19244275829283514 1.6861231222801746e-06 1.4297992291240542e-07 0.18633219379211186 0.06211063316386413 5.028302461569677e-11 10.298578606594686 -0.3015352380538592 INPYMSSPCHIEMILTEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 INPYMSSPCHIEMILTEK 18 0 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 21465500.0 3284900.0 12875000.0 5305600.0 False True 4306535.711016854 10954100.186356911 4756627.4069089 1.0 2.5435990599902496 1.104513633717383 22.038096363876924 -6.629619192758836 2.0820826796377503 2.0172402858716207 1.1103211298993745 0.11605723419505143 0.6621883152839593 0.5599783986381722 4.6257035031661715 0.26018441345243104 0.7334670279837397 2.346285232882569e-07 6.629619192758836 -0.9069191559722463 INPYMSSPCHIEMILTEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 INPYMSSPCHIEMILTEK 18 0 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 53100900.0 7305000.0 36081000.0 9714900.0 False True 11082219.067035422 29642063.647860333 7794745.756808061 1.0 2.6747408139613515 0.7033560435557439 23.401743455026743 -6.68164016636955 1.8960031324383189 2.0580790338155484 0.7107655646718356 0.3316104111646563 0.7095450899509609 0.43492824163742494 3.0242418488469682 0.30012758295537406 0.7899234240374894 2.0814205287494487e-07 6.68164016636955 -1.3473134691437127 INPYMSSPCHIEMILTEK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 INPYMSSPCHIEMILTEK 18 0 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 29334100.0 5808400.0 10509600.0 13016100.0 False True 7955922.446107943 10045251.121400312 9941965.254994119 1.0 1.2626130017537405 1.2496307401610927 22.923597782252894 -10.015187112792345 4.672027257882072 0.9999936760470771 1.2561218709687019 0.998076761652186 0.005299986142042607 3658268.5902461163 0.1554767812002654 252.56598182852034 0.0018143262217116497 9.65634752257992e-11 10.015187112792345 0.25612819492162475 INPYMSSPCHIEMILTEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INPYMSSPCHIEMILTEK 18 0 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 14279100.0 6755200.0 2849100.0 4674800.0 False True 5617248.106101067 2833751.3327979282 5652279.066166956 1.0 0.504473236587165 1.0062363205975966 22.421432095498062 -10.976640806153096 9.984958846131002 1.1429868662043055 0.7553547785923809 0.2406798463804538 0.20484392126513437 0.08815686591761215 0.0002062374159753385 0.026816235730589916 0.06611309130264073 1.0552593135253993e-11 10.976640806153096 -0.3876320876119246 INPYMSSPCHIEMILTEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INPYMSSPCHIEMILTEK 18 0 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 25414700.0 7305000.0 9700500.0 8409200.0 False True 9456466.503077555 9160658.647575172 6878811.885678409 1.0 0.9687189865891118 0.7274188391022943 23.172869777119192 -6.930779931575131 0.7403608982506281 1.0035653173976928 0.6768825051105288 0.9966893306389406 0.007007851103779823 0.09223492062107867 0.0757107066743465 0.006414358353752124 0.021740627208390078 1.1727894982573641e-07 6.930779931575131 -0.326682812287164 INSGGK(ub)LPNFGFVVFDDSEPVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 INSGGKLPNFGFVVFDDSEPVQK 23 1 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 22414900.0 8423100.0 8286900.0 5704900.0 True False 8155713.301071826 11595902.385612594 4210615.546668541 1.0 1.4218133911216149 0.5162780239117993 22.959379630309897 -6.780057702668205 1.5357799462466584 1.23882803794535 0.5091103915361751 0.7675290636446301 0.1783824719934591 0.2504966036665235 1.167022402658147 0.09148495589998643 0.2158435656383615 1.6593664205670484e-07 6.780057702668205 -0.7297176464091749 INSGGK(ub)LPNFGFVVFDDSEPVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INSGGKLPNFGFVVFDDSEPVQK 23 1 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 45503000.0 10643000.0 18357000.0 16503000.0 True False 13777573.30489452 17335416.812900126 13499623.335079545 1.0 1.2582344095924114 0.9798259124691986 23.715818467399117 -6.662988651317868 1.9617424156252097 1.1658026277603506 0.9809651404030847 0.24867778355610504 0.10987046327993076 0.47735536683350693 3.5343944895941415 0.04519398941141638 0.12188333380070128 2.1727579551255662e-07 6.662988651317868 -0.1848374873572659 INSGSSLEAVTTCELCK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 INSGSSLEAVTTCELCKEK 19 1 F5H6W4;Q9H992;Q9H992-2;H7BZU7 F5H6W4 MARCH7 E3 ubiquitin-protein ligase MARCH7 1 254400000.0 17372000.0 88188000.0 148840000.0 True False 26354594.063318223 72450162.38401107 119421708.7611104 1.0 2.7490524881523863 4.531343130317007 24.651551134789777 -6.970890432425004 0.23595218111423827 0.32702749989439844 7.004662125937783 0.9999885188184742 0.004884990172867706 0.07601480066307978 0.007989005911787833 0.043852312765860234 0.17503420801736486 1.0693246236761036e-07 6.970890432425004 6.6776346260433845 INSGSSLEAVTTCELCK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INSGSSLEAVTTCELCKEK 19 1 F5H6W4;Q9H992;Q9H992-2;H7BZU7 F5H6W4 MARCH7 E3 ubiquitin-protein ligase MARCH7 1 205830000.0 17372000.0 63128000.0 125330000.0 True False 22488396.45331465 59614871.3060282 102521225.99439618 1.0 2.650916948648926 4.5588499921382875 24.422677456882226 -6.969228474443473 0.27599115861354545 0.5588601340149899 6.708729391769636 0.9999757242417645 0.007164691672188083 0.07655384305256842 0.009922797369716822 0.03607587976788071 0.17602828380320484 1.0734245546005503e-07 6.969228474443473 6.149869257754647 INSITVDNCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 INSITVDNCK 10 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 9155300.0 1323600.0 4226900.0 3604800.0 False True 1735252.4177606334 3596262.996327149 3231809.875683279 1.0 2.072472546079593 1.862443666757124 20.726714108418136 -10.579824289194056 7.095256660440362 0.9989898704560444 1.9674581064183418 0.965859573032025 0.08574393093143894 0.0013711520387993375 8.1198358271866e-05 0.08308518505441446 0.027673734711318492 2.6313323849151864e-11 10.579824289194056 0.9684682359622975 INSITVDNCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 INSITVDNCK 10 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 22243060.0 967560.0 19926000.0 1349500.0 False True 1467859.2581109921 16370049.617451424 1082770.7334931376 1.0 11.152329167115287 0.7376529646899321 20.485282215053424 -6.651993854106345 2.001295788112574 7.577455725202397 0.7813446074906119 0.20219351232136717 4.331013724308764 0.5036859775110585 3.8690295849307437 1.7536801898266612 4.798049831584439 2.228466685066689e-07 6.651993854106345 -6.796111117711785 INSITVDNCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INSITVDNCK 10 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 9255700.0 1323600.0 3468300.0 4463800.0 False True 1812970.6889450594 3315059.037865637 3409542.374846741 1.0 1.8285232398294426 1.8806384436533294 20.789924169941028 -11.116532318508499 0.48023682886202695 6.793841166051155e-21 1.8793463774531867 0.9997678270100633 0.006146917452500657 3.073990547972513 0.23430048793987554 3.3485686412943507 0.011011805999964182 7.646587833848879e-12 11.116532318508499 1.8793463774531867 INSYGYGDHYIHIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 INSYGYGDHYIHIK 14 0 Q96EY1;Q96EY1-2;Q96EY1-3 Q96EY1 DNAJA3 DnaJ homolog subfamily A member 3, mitochondrial 0 31639000.0 10306000.0 11297000.0 10036000.0 False True 13511265.80344596 9611531.635361105 8997570.992109789 1.0 0.7113716638532673 0.6659310180852942 23.687659504145987 -13.999999999999998 0.2602245607826085 3.1153723105676985 0.6493584450021098 0.9995627914252444 0.0030933278647890883 14.427013055536031 0.16142787527782915 16.05067198804792 0.0198425263226683 1.0000000000000041e-14 13.999999999999998 -2.4660138655655888 INSYGYGDHYIHIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 INSYGYGDHYIHIK 14 0 Q96EY1;Q96EY1-2;Q96EY1-3 Q96EY1 DNAJA3 DnaJ homolog subfamily A member 3, mitochondrial 0 21193600.0 4654400.0 2888200.0 13651000.0 False True 4506648.619689755 4041473.3217640324 10075393.578778267 1.0 0.896780215814175 2.235673208414432 22.103623537816937 -6.888289408902422 1.032478739508455 0.9250815667541331 2.3470312123827237 0.9797795316549562 0.08649838744670245 0.1205407945661997 0.23005778153397166 0.06397432246512916 0.15853339297390281 1.2933336913587856e-07 6.888289408902422 1.4219496456285907 up INSYGYGDHYIHIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INSYGYGDHYIHIK 14 0 Q96EY1;Q96EY1-2;Q96EY1-3 Q96EY1 DNAJA3 DnaJ homolog subfamily A member 3, mitochondrial 0 30509400.0 10306000.0 8382400.0 11821000.0 False True 14116406.709177822 8012037.851110043 9029123.261137016 1.0 0.5675692133396095 0.639619093382079 23.75086956566888 -10.709910614065006 6.816523178678343 1.0041757936206115 0.6035941533608626 0.9758221122644439 0.02941424035546457 0.0018782356638336287 7.993155505884997e-05 0.02865707820396 0.009493405253171364 1.9502459555824308e-11 10.709910614065006 -0.40058164025974885 INSYGYGDHYIHIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INSYGYGDHYIHIK 14 0 Q96EY1;Q96EY1-2;Q96EY1-3 Q96EY1 DNAJA3 DnaJ homolog subfamily A member 3, mitochondrial 0 12352900.0 4654400.0 4578400.0 3120100.0 False True 3870339.8248811006 4553735.250458751 3772498.4842875656 1.0 1.1765724604295296 0.974720219665326 21.884028813251213 -6.6755423272474985 1.917418401658037 1.1121600368344196 0.9755069086371495 0.30400527993607107 0.0749090052453632 0.44848688511112006 3.183801513893306 0.03139123893808914 0.08327747141313174 2.110851457789985e-07 6.6755423272474985 -0.13665312819727005 INSYGYGDHYIHIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INSYGYGDHYIHIK 14 0 Q96EY1;Q96EY1-2;Q96EY1-3 Q96EY1 DNAJA3 DnaJ homolog subfamily A member 3, mitochondrial 0 14044000.0 5291400.0 4578400.0 4174200.0 False True 6849821.609087564 4323608.015262943 3414538.430908864 1.0 0.6312000898719569 0.49848574543588736 22.70763498556727 -13.99999999996238 0.14226094680183177 2.7655303503048416 0.33863398992918253 0.9995940752682663 0.004274696496103163 11.93699435556541 0.1183325020418012 5.8434418475233265 0.1431336729076555 1.0000000000866224e-14 13.99999999996238 -2.4268963603756593 INTTTNEIFYCTFRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 INTTTNEIFYCTFRR 15 1 Q9NZQ7-2;Q9NZQ7 Q9NZQ7-2 CD274 Programmed cell death 1 ligand 1 0 15293300.0 2888100.0 6705900.0 5699300.0 False True 4381458.8483922 5509179.751564159 4572830.85690807 1.0 1.2573847985781683 1.0436776916405583 22.06297987817264 -10.217295850998577 5.740339507578525 0.9999951633061451 1.1505312451093632 0.39814760376353797 0.08724556106726875 5.4017116194553e-06 7.366300500257102e-07 0.08447786618512014 0.028158383753669476 6.063231481426258e-11 10.217295850998577 0.1505360818032181 INTTTNEIFYCTFRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INTTTNEIFYCTFRR 15 1 Q9NZQ7-2;Q9NZQ7 Q9NZQ7-2 CD274 Programmed cell death 1 ligand 1 0 15387600.0 2888100.0 8107000.0 4392500.0 False True 3738702.3829621226 7655838.323374265 3593110.0708560203 1.0 2.0477260662049943 0.9610580631479012 21.83410620026509 -6.654494521468762 1.9927859768185596 1.6774456762234138 0.9656459779963162 0.21239988420604572 0.4466918013030275 0.4975819830576733 3.792602513587818 0.18148640133120503 0.49482486334042736 2.215672046361645e-07 6.654494521468762 -0.7117996982270975 INTVQYGTSDNK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 INTVQYGTSDNKK 13 1 Q96AP4;X6R6X3 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 12725500.0 2278700.0 3433300.0 7013500.0 True False 3456954.4952845476 2820600.79050466 5627278.650873754 1.0 0.8159207170219034 1.627813920764544 21.721070182511006 -6.8471302448554505 1.2489532017438065 0.9019631849426086 1.6585005253190248 0.936010892600812 0.0879200053516544 0.16064304718667405 0.48367151787184454 0.05512405865852173 0.12734129698406776 1.4219022948706707e-07 6.8471302448554505 0.7565373403764162 INTVQYGTSDNK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INTVQYGTSDNKK 13 1 Q96AP4;X6R6X3 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 3772810.0 1786900.0 1024400.0 961510.0 True False 2447565.2191567887 979138.6207622057 734421.1409200443 1.0 0.40004597756930416 0.30006192896181944 21.222915872503687 -13.999999999999961 0.2521278025570576 5.217557476018321 0.2606658458319121 0.9995467286683627 0.006580672836632652 14.083356772798732 0.15888675824352355 30.120567960757164 0.04560257746095113 1.00000000000009e-14 13.999999999999961 -4.9568916301864085 INTVQYGTSDNK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INTVQYGTSDNKK 13 1 Q96AP4;X6R6X3 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 14092900.0 2278700.0 3978600.0 7835600.0 True False 2949822.0698922426 3757187.412529522 6409601.200045405 1.0 1.2736996752711842 2.1728772272286743 21.492196504603456 -6.9493927727914455 0.5654720074856388 0.9885596320024364 2.5013959147136684 0.9991527561494962 0.014583038909253786 0.0837305285990379 0.03697876130674432 0.015530846314367824 0.07483809896864853 1.1235883491376546e-07 6.9493927727914455 1.512836282711232 up INVELSTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 INVELSTK 8 0 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 0 61318000.0 17422000.0 16695000.0 27201000.0 False True 22840410.71488797 14204171.076600302 24386501.450416368 1.0 0.6218877258341794 1.0676910216207547 24.44508525760076 -6.681917269162115 1.8946784546723932 0.7611858084438109 1.0660378547894842 0.3331278679598534 0.16018467838359632 0.4342601162757297 3.0155209924361883 0.06779236193308927 0.17838580972600987 2.0800928962324706e-07 6.681917269162115 0.3048520463456733 INVELSTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 INVELSTK 8 0 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 0 30075800.0 12185000.0 3939800.0 13951000.0 False True 11798193.844731785 5512982.685785588 10296814.578971194 1.0 0.46727344526953035 0.8727449908418823 23.492062682214694 -9.965713095534523 6.292177109187128 1.0000001024673306 0.6700092180556901 0.468967467023902 0.16553306531171066 2.379751703758893e-07 3.9095526684395616e-08 0.1602767514538412 0.053425567099901546 1.0821486063309874e-10 9.965713095534523 -0.3299908844116405 INVELSTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 INVELSTK 8 0 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 0 51665000.0 14644000.0 24098000.0 12923000.0 False True 22216018.61980379 19797523.62146663 10368763.385647884 1.0 0.891137334743622 0.46672464419006954 24.405096955640428 -6.945465019303362 0.6065951820790735 1.0047195018842485 0.3311692763375381 0.9987955981799537 0.007984208934844448 0.08535955150364159 0.04390459930103817 0.008142140494367105 0.035745269377683485 1.1337961572076623e-07 6.945465019303362 -0.6735502255467104 down INVELSTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INVELSTK 8 0 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 0 40940200.0 17422000.0 8857200.0 14661000.0 False True 23863384.21184707 8465859.617156407 11198373.752773002 1.0 0.3547635801360269 0.46927014430809544 24.50829531912365 -9.955414515254871 5.912715601507461 1.0000003917671123 0.41201686222398726 0.9723425840981802 0.046747109070796 2.413890465587895e-07 4.260540523364911e-08 0.0452627237407947 0.015087564576114943 1.1081166610491302e-10 9.955414515254871 -0.587983529543125 INVELSTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INVELSTK 8 0 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 0 24585800.0 12185000.0 7307600.0 5093200.0 False True 10132367.387026506 7268232.508354965 6158164.571703931 1.0 0.7173281653467498 0.6077715440508851 23.27246795764897 -13.99999999996954 0.1311632592195584 2.343599457879523 0.45658777838467113 0.9996403814293131 0.003133611146162105 11.935103031679954 0.11273794175011774 4.129934662508406 0.13451302718253752 1.000000000070135e-14 13.99999999996954 -1.8870116794948517 INVELSTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INVELSTK 8 0 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 0 41535800.0 14644000.0 18068000.0 8823800.0 False True 18956946.676395305 17062499.91695153 7217958.939833661 1.0 0.9000658285438609 0.38075535385776416 24.176223277732877 -6.938949465916464 0.6692703894889885 1.005948436478867 0.24494048218458586 0.9980229668714735 0.012069418945230366 0.088249327177454 0.05681788446344673 0.011657139665089643 0.044906901724359974 1.1509343027493587e-07 6.938949465916464 -0.761007954294281 down INVELSTK(ub)GQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 INVELSTKGQK 11 1 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 2282150.0 576020.0 921730.0 784400.0 True False 755167.7981856148 784211.4768753999 703237.8124961057 1.0 1.0384599009115143 0.9312338452271437 19.52643772114342 -6.809685105219858 1.4157095739899788 1.0209679057887353 0.929368679084203 0.8590511593248105 0.016651832824078693 0.20722206339122196 0.8186002007789062 0.009248561803773455 0.02139835715775485 1.5499400297448816e-07 6.809685105219858 -0.09159922670453235 INVELSTK(ub)GQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 INVELSTKGQK 11 1 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 3897700.0 1007900.0 1529600.0 1360200.0 True False 975904.7661965664 2140377.256758626 1003922.8148746757 1.0 2.1932234895218374 1.028709818466514 19.896380843495983 -6.640479290087166 2.0423915371879207 1.7799993648503483 1.0335225774714139 0.15657561447366153 0.51048006180175 0.5321577822330692 4.243034137252662 0.20348171045323618 0.5653859618172034 2.2883408315643024e-07 6.640479290087166 -0.7464767873789344 INVELSTK(ub)GQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INVELSTKGQK 11 1 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 7967660.0 576020.0 2875100.0 4516540.0 True False 788990.1603551925 2748068.5753157176 3449826.2730611437 1.0 3.4830200849128143 4.372457916975897 19.58964778266631 -9.329491040096077 0.33165548265918593 1.0417305839339692e-23 4.646669979906565 0.9984315150792312 0.05651967879032825 0.7162419819048428 0.1287128170463385 1.1312097732795356 0.27539659046189535 4.682836124056183e-10 9.329491040096077 4.646669979906565 INVELSTK(ub)GQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INVELSTKGQK 11 1 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 4273130.0 1007900.0 2292700.0 972530.0 True False 838113.5075407479 2280348.770034679 1175881.526529337 1.0 2.720811381176567 1.403009873900842 19.67678611893026 -6.578553312202877 2.2723770955277502 2.172816504850273 1.4061674813854002 0.0 0.7478369836612211 0.7036436526648856 6.831922313651492 0.2765741603533458 0.8363571944642721 2.639044344260636e-07 6.578553312202877 -0.7666490234648726 INVELSTK(ub)GQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 INVELSTKGQK 11 1 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 23755400.0 1323500.0 6927300.0 15504600.0 True False 1713296.8400853043 6541789.665413894 12682921.890630433 1.0 3.8182465013407607 7.402641266763181 20.70834369892373 -6.967853780709708 0.3051272116649255 0.4150353117529874 10.918992432118623 0.9999604706205945 0.016473181407022707 0.07700545154004905 0.011509760421606445 0.058005914441682384 0.31976563433455946 1.0768277014946193e-07 6.967853780709708 10.503957120365635 INVYYNEAAGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 INVYYNEAAGNK 12 0 Q13885 Q13885 TUBB2A Tubulin beta-2A chain 0 3269550.0 429550.0 1330000.0 1510000.0 False True 563144.2097681172 1131569.184299394 1353759.6849427833 1.0 2.009377286797167 2.4039307542560255 19.103144888884874 -10.027617464998668 0.22799790333449238 1.3237644312288244e-17 2.6735802624242364 0.9992341401394997 0.016360656913775376 1.5196938183912214 0.10431915949957278 1.1517486206105025 0.1995837911209549 9.383881935295969e-11 10.027617464998668 2.6735802624242364 INVYYNEATGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 INVYYNEATGGK 12 0 P68371 P68371 TUBB4B Tubulin beta-4B chain 0 44272000.0 0.0 44272000.0 0.0 False True 0.0 37666790.17090438 0.0 0.0 INVYYNEATGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 INVYYNEATGGK 12 0 P68371 P68371 TUBB4B Tubulin beta-4B chain 0 59589800.0 18353000.0 5777800.0 35459000.0 False True 17770394.060924273 8084905.67082896 26171224.152801875 1.0 0.45496490641178544 1.4727430389599734 24.082972337893143 -6.761217203131757 1.6076668982995108 0.6838957485907246 1.4767154916067224 0.6960008377866882 0.22928653845574232 0.2808779463946042 1.43101886526577 0.11250898624640915 0.27007678052632117 1.732937089427176e-07 6.761217203131757 0.7928197430159979 INVYYNEATGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INVYYNEATGGK 12 0 P68371 P68371 TUBB4B Tubulin beta-4B chain 0 41360000.0 0.0 0.0 41360000.0 False True 0.0 0.0 31591619.83593827 0.0 INVYYNEATGGK(ub)YVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 INVYYNEATGGKYVPR 16 1 P68371 P68371 TUBB4B Tubulin beta-4B chain 1 40507000.0 11805000.0 15219000.0 13483000.0 True False 15476469.319782617 12948384.523197364 12087908.49806857 1.0 0.8366497717051163 0.7810507841486392 23.883573048108964 -13.999999999999998 0.15044839049255312 1.7904166051343233 0.7201950848158288 0.9995647464319242 0.0019386333336068782 11.959398823868641 0.12217979571409215 2.7630875888015285 0.054875599601084804 1.0000000000000041e-14 13.999999999999998 -1.0702215203184946 INVYYNEATGGK(ub)YVPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 INVYYNEATGGKYVPR 16 1 P68371 P68371 TUBB4B Tubulin beta-4B chain 1 55532000.0 15248000.0 19737000.0 20547000.0 True False 14763960.586333228 27618087.02709531 15165124.303212762 1.0 1.8706421536143187 1.0271718225291717 23.815576455513934 -10.268131049304293 4.950254268637474 0.9999021752024788 1.448906987940994 0.27413647300756283 0.3443453207639517 0.0004065708001763879 6.010968271762626e-05 0.3334898584244527 0.11113697438236804 5.3934784857154255e-11 10.268131049304293 0.4490048127385151 INVYYNEATGGK(ub)YVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INVYYNEATGGKYVPR 16 1 P68371 P68371 TUBB4B Tubulin beta-4B chain 1 44402000.0 11805000.0 16384000.0 16213000.0 True False 16169627.51812966 15660100.705357295 12383823.317216322 1.0 0.968488648721124 0.76586942422337 23.946783109631856 -6.934387865396498 0.7098479417056018 1.0026371707907489 0.7192078430550652 0.9973325793023734 0.005358051589238327 0.09042259160367236 0.06698139773385124 0.005015788365405946 0.017911878281359858 1.1630868206334606e-07 6.934387865396498 -0.28342932773568363 INVYYNEATGGK(ub)YVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INVYYNEATGGKYVPR 16 1 P68371 P68371 TUBB4B Tubulin beta-4B chain 1 49972000.0 15248000.0 20772000.0 13952000.0 True False 12679387.600933958 20660097.11308081 16869298.693240654 1.0 1.6294238935923844 1.3304505883232143 23.59598173094821 -10.003416026618764 4.423145829085262 0.9999816984749839 1.4799372408597207 0.7745675263186391 0.12205534104035441 37399378.144670725 50002104.73927733 9005.353915422154 0.044667683805653904 9.921651616374578e-11 10.003416026618764 0.4799555423847368 INVYYNEATGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 INVYYNEATGNK 12 0 Q9BVA1 Q9BVA1 TUBB2B Tubulin beta-2B chain 0 54215000.0 13672000.0 17394000.0 23149000.0 False True 17924124.399836324 14798883.001280963 20753763.540887758 1.0 0.8256404983116554 1.1578676357031572 24.095399308669098 -6.7640991903805725 1.5970360420272784 0.8992403851820607 1.1593339700183962 0.7074859189993321 0.07338565169550328 0.27608010450706205 1.3886548702953978 0.036240704186259895 0.08674345860696372 1.7214753549387828e-07 6.7640991903805725 0.2600935848363355 INVYYNEATGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 INVYYNEATGNK 12 0 Q9BVA1 Q9BVA1 TUBB2B Tubulin beta-2B chain 0 36131200.0 10279000.0 3521200.0 22331000.0 False True 9952698.771440133 4927233.522815421 16481841.184359927 1.0 0.4950650708885527 1.6560172836392435 23.246656348874392 -6.788493288761491 1.5023509392245566 0.717240596887525 1.6678573834918302 0.7964120665865445 0.21445546740938476 0.23760092257585932 1.0594631065426645 0.11236849158941588 0.26337344318574546 1.6274464646999574e-07 6.788493288761491 0.9506167866043053 INVYYNEATGNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 INVYYNEATGNK 12 0 Q9BVA1 Q9BVA1 TUBB2B Tubulin beta-2B chain 0 96991100.0 9033500.0 78791000.0 9166600.0 False True 13704479.937312048 64730130.45310722 7354817.492136493 1.0 4.723282514126777 0.536672498758026 23.708144245487457 -6.672093069973671 1.9298316495872414 3.372258161081182 0.5533896648302462 0.28838881351192036 1.5808092126586692 0.45633901051626363 3.2784509109262157 0.658970011131637 1.7558893894530425 2.1276830313846954e-07 6.672093069973671 -2.818868496250936 INVYYNEATGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 INVYYNEATGNK 12 0 Q9BVA1 Q9BVA1 TUBB2B Tubulin beta-2B chain 0 61113000.0 13672000.0 16247000.0 31194000.0 False True 18726907.871907547 15529153.818355683 23826619.660596184 1.0 0.8292428159830458 1.2723200126561618 24.15860937019199 -6.802268355401949 1.4470607265890796 0.9060548617328079 1.2787538183366562 0.8385872025286487 0.07330658492098123 0.21754425447582937 0.8991525149002222 0.03985246114275917 0.09253924624866228 1.5766367472235077e-07 6.802268355401949 0.37269895660384833 INVYYNEATGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 INVYYNEATGNK 12 0 Q9BVA1 Q9BVA1 TUBB2B Tubulin beta-2B chain 0 21213100.0 10279000.0 6799200.0 4134900.0 False True 8547443.936909765 6762571.360064475 4999488.472382506 1.0 0.7911805459012357 0.5849103555735069 23.02706162430867 -6.971276549143832 0.2256222664699826 1.0886208074207924 0.2816070237267691 0.9999906989865498 0.0005167815958915333 0.07589060316988755 0.007530854336976408 0.005475307189449685 0.020664966062024812 1.0683743453605923e-07 6.971276549143832 -0.8070137836940232 IPAILYLCYTDVMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPAILYLCYTDVMK 14 0 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 0 15410400.0 6104900.0 3872300.0 5433200.0 False True 7902913.395569921 3656803.100974728 4444413.349339766 1.0 0.4627158261691942 0.5623765726486563 22.913953167741155 -10.126516835069575 5.565834240111392 1.0000067030235293 0.5125461994089784 0.9696026030532691 0.040686329376883275 56791113.15596311 0.06576440343970036 4878.60426388634 0.013928012738582825 7.472796659461524e-11 10.126516835069575 -0.48746050361455096 IPAMTIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPAMTIAK 8 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 45083500.0 1926500.0 20955000.0 22202000.0 False True 2525660.156252536 17828595.68195024 19904750.01662232 1.0 7.058984415545254 7.881008839350785 21.268229097652508 -9.56279129742155 0.5738766700608262 3.304859704042844e-23 7.814513447912527 0.9987870972055237 0.10686215450321933 0.8706681057019943 0.25801341740071826 2.0588583525573005 0.1470894208132457 2.736583490472677e-10 9.56279129742155 7.814513447912527 IPAMTIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPAMTIAK 8 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 26467300.0 11714000.0 4523300.0 10230000.0 False True 11342145.481919423 6329477.278697889 7550456.106578399 1.0 0.558049382172689 0.6656991059244147 23.43519023071351 -9.925941027764878 6.757515396875205 1.0000000214290259 0.6118742440485582 0.9454516631618599 0.043947815690564475 1.4213512753433116e-08 2.2519943448545825e-09 0.04255229210423986 0.014184096522643498 1.1859297729653547e-10 9.925941027764878 -0.3881257773804677 IPAMTIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPAMTIAK 8 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 173457000.0 1997100.0 169600000.0 1859900.0 False True 3029746.7075669356 139333554.90915164 1492289.9497768711 1.0 45.98851599084488 0.49254610824390255 21.530765756087845 -6.2430896895221215 24.999887818132052 9.999999999999998 0.492714873351169 0.0 21.41785301451828 3453.889724372415 12494792.049771985 9.12131591708306 62.124005957945364 5.71360628371681e-07 6.2430896895221215 -9.50728512664883 IPAMTIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPAMTIAK 8 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 52013500.0 1926500.0 18976000.0 31111000.0 False True 2638779.111704936 18137577.574759524 23763222.55115757 1.0 6.873473226427313 9.005385272965864 21.3314391591754 -8.941182440297071 0.42787617138423506 2.1520125494429202e-27 9.28392919744002 0.9971491821620729 0.18073977401276406 0.4267642125222027 0.15705747476347456 1.3304219694577286 0.4989475013372772 1.1450318304944239e-09 8.941182440297071 9.28392919744002 IPAMTIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPAMTIAK 8 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 10089500.0 1997100.0 4500400.0 3592000.0 False True 2585285.3187263804 4249948.783830457 2938292.8570323987 1.0 1.6438993224640133 1.1365449050242256 21.301892078180295 -10.188959407293511 4.242066247372338 0.999872955844099 1.390222113726719 0.44095051130301877 0.207126573830164 29777236.554680098 35760824.10988658 31709.95419708549 0.07090493052073182 6.472031058055847e-11 10.188959407293511 0.39034915788262003 IPAMTIAK(ub)NAGVEGSLIVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPAMTIAKNAGVEGSLIVEK 20 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 10697600.0 3440500.0 3075300.0 4181800.0 True False 3331283.2107344884 4303283.327477642 3086461.128689104 1.0 1.2917794901409314 0.9265081752111357 21.667646580002177 -6.693952522882339 1.8522307596037586 1.1822458307337997 0.9277029419374255 0.3890077246297552 0.12330517492608001 0.40825172811332233 2.718473248466426 0.05319437718158123 0.13784285024977755 2.0232403474329105e-07 6.693952522882339 -0.2545428887963742 IPAMTIAK(ub)NAGVEGSLIVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPAMTIAKNAGVEGSLIVEK 20 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 9189000.0 3440500.0 3363400.0 2385100.0 True False 2860928.189993002 3345280.696617367 2883813.3825435974 1.0 1.1692990786411699 1.007999219494793 21.448051855436454 -10.895249069409758 2.5251639754228274 0.9518097483374263 1.0886491486516041 0.28710715013226384 0.06585039501277021 29670339.152944326 14025791.076019509 8478330.420389706 0.023244762816615173 1.2727729319212131e-11 10.895249069409758 0.13683940031417785 IPAMTIAK(ub)NAGVEGSLIVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPAMTIAKNAGVEGSLIVEK 20 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 20346900.0 3323800.0 4699100.0 12324000.0 True False 4302724.621893119 4437590.954159124 10081158.454918511 1.0 1.0313444024699554 2.342970870974073 22.03681907883135 -6.912042293397934 0.8817013246906648 0.9619651161043479 2.5201016049913574 0.9916699266479343 0.05711860831684018 0.10308330236173868 0.13155257853946778 0.04724114244789235 0.1323299921739512 1.2244969468670688e-07 6.912042293397934 1.5581364888870095 up IPAYFVTVSDPAVPPGEDPDGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPAYFVTVSDPAVPPGEDPDGR 22 0 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 0 4643100.0 1164300.0 1797800.0 1681000.0 False True 1526408.57509724 1529575.2477695115 1507066.2452906077 1.0 1.0020745904628252 0.9873282094177176 20.541709750612203 -6.871285124255353 1.127376237579661 1.001182760148691 0.9864436125942722 0.9659431474808616 0.001202811584590909 0.13562358556383577 0.32139731024233076 0.0008273959486512757 0.0019632364160984753 1.3449770559515325e-07 6.871285124255353 -0.014739147554418741 IPAYFVTVSDPAVPPGEDPDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPAYFVTVSDPAVPPGEDPDGR 22 0 P26640;A0A140T936;H0Y426 P26640 VARS Valine--tRNA ligase 0 6116700.0 1164300.0 1814400.0 3138000.0 False True 1594773.174024429 1734233.8085815574 2396869.0291386433 1.0 1.0874485706360346 1.5029529391255785 20.604919812135094 -6.940949434155392 0.6506752130042078 0.995401726330938 1.618200039945752 0.9982855817766847 0.00908464016246457 0.08733622557982348 0.05265801905653768 0.008908153945137668 0.035614699007174636 1.1456463237564701e-07 6.940949434155392 0.6227983136148139 IPDHDPAPNVTVLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPDHDPAPNVTVLLR 15 0 Q9P2E9;Q9P2E9-3;A2A2S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 11457100.0 4463300.0 3486200.0 3507600.0 False True 5851429.522658681 2966072.549101168 3144667.199275042 1.0 0.5068970817499465 0.5374186234488247 22.480357692021727 -10.056053223514647 6.075439008178399 1.0000008798190887 0.522157852599368 0.9969494473819296 0.012460367220951453 1.4849182523156272e-07 2.3081026513775618e-08 0.01206472079441382 0.00402156622785526 8.789147977529394e-11 10.056053223514647 -0.4778430272197207 IPDHDPAPNVTVLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPDHDPAPNVTVLLR 15 0 Q9P2E9;Q9P2E9-3;A2A2S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 6873100.0 2931000.0 1723700.0 2218400.0 False True 2837957.009348284 2411982.398976751 1637334.48942654 1.0 0.8499009643316074 0.5769412588115779 21.436421304293532 -6.961861511886776 0.40835218172312693 1.0136902370536096 0.4030492987705745 0.9998331295981054 0.0022622138637533773 0.07904273400446303 0.018722772375260925 0.003513449659423732 0.022802398092727386 1.0917884311665106e-07 6.961861511886776 -0.6106409382830351 IPDHDPAPNVTVLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPDHDPAPNVTVLLR 15 0 Q9P2E9;Q9P2E9-3;A2A2S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 11762200.0 4463300.0 3022300.0 4276600.0 False True 6113502.626147233 2888764.792590409 3266555.1593417283 1.0 0.4725220498369077 0.534318108472022 22.543567753544618 -10.20134657435876 5.3924222166753095 1.0000245082712929 0.5034200791555433 0.9885187430187224 0.025228135295463174 7.4337013759239834e-06 1.1009742794846666e-06 0.024428240224084602 0.008142345654560191 6.29004026643063e-11 10.20134657435876 -0.49660442911574953 IPDQLVILDMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPDQLVILDMK 11 0 P49755;G3V2K7 P49755 TMED10 Transmembrane emp24 domain-containing protein 10 0 4070000.0 1283500.0 1213800.0 1572700.0 False True 1682680.92943168 1032705.7713553435 1409972.090403655 1.0 0.6137264369568487 0.8379319369120494 20.682330207568377 -10.216521240580292 5.48863036632719 1.0000137339641573 0.7258291869344273 0.6659799669047786 0.0915315120693828 1.5383483268598992e-05 2.1960204020313147e-06 0.0886294428329786 0.02954166849148082 6.074055549982938e-11 10.216521240580292 -0.27418454702972994 IPDQLVILDMK(ub)HGVEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPDQLVILDMKHGVEAK 17 1 P49755;G3V2K7 P49755 TMED10 Transmembrane emp24 domain-containing protein 10 1 13492420.0 673030.0 928390.0 11891000.0 True False 651665.031047997 1299100.9684898916 8776390.377646498 1.0 1.9935103260039884 13.467640520057447 19.313771055109704 -6.923952607759674 0.7948493095906066 0.7810478729615713 15.49740176075537 0.9952105470040079 0.39154516470801526 0.09590158517517289 0.09396555675637416 0.3446220039405999 1.0747898541561587 1.1913720090067719e-07 6.923952607759674 14.7163538877938 up IPDQLVILDMK(ub)HGVEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPDQLVILDMKHGVEAK 17 1 P49755;G3V2K7 P49755 TMED10 Transmembrane emp24 domain-containing protein 10 1 20116230.0 673030.0 2564200.0 16879000.0 True False 559654.2652844036 2550386.145646153 20408320.86032175 1.0 4.557074436572202 36.46594357670214 19.09417633054398 -6.928030196788112 0.762784907652893 0.4776485177292518 42.699802211436385 0.9961367726769778 0.9911621147062284 0.09367369968921117 0.08278536984527042 0.8926325887222125 2.9191023309687 1.1802385700152777e-07 6.928030196788112 42.222153693707135 IPDSDPSSSK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPDSDPSSSKTR 12 1 P37268;P37268-5;E9PNM1;A0A1W2PQ47;P37268-2;P37268-3;P37268-4 P37268 FDFT1 Squalene synthase 1 35757100.0 1846000.0 5141700.0 28769400.0 True False 1787399.7404493124 7194807.623611283 21233831.07650018 1.0 4.025292977721183 11.879732661907218 20.769430889249765 -6.954647214637792 0.5052599146132498 0.8496215490241823 15.397216634935942 0.999517301396495 0.10073780523080034 0.0816716537818148 0.02864222378540221 0.11700280005890075 0.6480645565021481 1.1100761843302742e-07 6.954647214637792 14.54759508591176 IPDSDPSSSK(ub)TR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPDSDPSSSKTR 12 1 P37268;P37268-5;E9PNM1;A0A1W2PQ47;P37268-2;P37268-3;P37268-4 P37268 FDFT1 Squalene synthase 1 45997310.0 799610.0 40779400.0 4418300.0 True False 1213066.8293213153 33501997.459093526 3545021.0683903196 1.0 27.617602467818834 2.9223625464836775 20.210227601789693 -6.266483279271629 4.861424792883813 9.999999999999998 2.582330635970128 0.11187683063494347 11.42191204386484 0.7860568589019261 50.608335226229904 4.5560729178344905 19.320954736425556 5.41398091795163e-07 6.266483279271629 -7.41766936402987 IPDSDPSSSK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPDSDPSSSKTR 12 1 P37268;P37268-5;E9PNM1;A0A1W2PQ47;P37268-2;P37268-3;P37268-4 P37268 FDFT1 Squalene synthase 1 32656700.0 1846000.0 5744500.0 25066200.0 True False 1535030.7916660588 5713553.238306027 30307426.52698599 1.0 3.722109855597602 19.743855752946537 20.54983616468404 -6.93624287378315 0.6936340684747243 0.8032488245756761 23.625310482866226 0.9976292395025557 0.40263809688876895 0.08952319808748284 0.06273266167850822 0.3815656361559222 1.4032946299924896 1.1581295055105969e-07 6.93624287378315 22.82206165829055 IPDSDPSSSK(ub)TR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPDSDPSSSKTR 12 1 P37268;P37268-5;E9PNM1;A0A1W2PQ47;P37268-2;P37268-3;P37268-4 P37268 FDFT1 Squalene synthase 1 88496010.0 799610.0 22299100.0 65397300.0 True False 1035110.9076695218 21058135.48251571 53495662.43296359 1.0 20.343844631998515 51.68109237048352 19.981353923882143 -7.076038911687168 0.4135157093742917 4.653257859837711e-19 69.69131966015189 0.9995757380511462 0.43013370563058967 0.09926670335946422 0.026648181480166858 0.5880018084418815 3.333036130429318 8.393847763971224e-08 7.076038911687168 69.69131966015189 IPDWFLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPDWFLNR 8 0 P62269;J3JS69 P62269 RPS18 40S ribosomal protein S18 0 30557300.0 6897300.0 10902000.0 12758000.0 False True 9042427.093548212 9275464.095663162 11437924.54337751 1.0 1.0257715102045137 1.2649175298895678 23.108278630222866 -6.927443923874512 0.7674698006236358 0.9959980139961524 1.310965161762461 0.9960119222468893 0.007532288787609643 0.09398649437490281 0.08433856362780333 0.0067607460317841385 0.021950484513734648 1.1818329010174609e-07 6.927443923874512 0.3149671477663085 IPDWFLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPDWFLNR 8 0 P62269;J3JS69 P62269 RPS18 40S ribosomal protein S18 0 26537400.0 9523000.0 4063400.0 12951000.0 False True 9220697.577626657 5685936.810351062 9558744.578328138 1.0 0.6166493112351465 1.0366617599000023 23.136444468971536 -6.6665553904866135 1.949719699859545 0.7545890775715882 1.034937089818542 0.26387052241111786 0.1629690802237279 0.46904384724360765 3.434147916401575 0.06737368630071705 0.18080909239384638 2.1549867762042396e-07 6.6665553904866135 0.2803480122469537 IPDWFLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPDWFLNR 8 0 P62269;J3JS69 P62269 RPS18 40S ribosomal protein S18 0 33605300.0 6897300.0 12812000.0 13896000.0 False True 9447418.202523991 12245923.476381691 10614050.997103453 1.0 1.2962190530646822 1.1234869431595376 23.171488691745758 -10.220928558358708 3.8594017514530004 0.9998012031858511 1.20985299806356 0.6630716616931498 0.07051758895127215 16332727.864663832 11.116137326010637 29987.764162084473 0.025099624956154195 6.012726389730346e-11 10.220928558358708 0.21005179487770886 IPDWFLNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPDWFLNR 8 0 P62269;J3JS69 P62269 RPS18 40S ribosomal protein S18 0 17425900.0 9523000.0 4020100.0 3882800.0 False True 7918796.44043114 3998442.923372624 4694675.527961213 1.0 0.5049306360443492 0.592852154147002 22.916849744405813 -10.833256275791888 7.377018993392551 1.0265588637365548 0.5488913950956779 0.9722993844883818 0.03589380946039559 0.013795551653588724 0.0003118222566770799 0.030579646245376395 0.011584677189337853 1.4680597246216484e-11 10.833256275791888 -0.47766746864087695 IPDWFLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPDWFLNR 8 0 P62269;J3JS69 P62269 RPS18 40S ribosomal protein S18 0 14475500.0 4627200.0 3779000.0 6069300.0 False True 5990001.615748194 3568695.327992024 4964749.676276932 1.0 0.5957753531500957 0.8288394552723003 22.51412496149209 -10.204175978684498 5.476710398180277 1.0000126017538458 0.7123074042111697 0.6701448077485723 0.09514802125998481 1.4640986245534205e-05 2.127541144352476e-06 0.09213070784379171 0.030708891813694784 6.249194204319875e-11 10.204175978684498 -0.2877051975426761 IPELNK(ub)VAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPELNKVAR 9 1 P02786;G3V0E5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 1 22167950.0 682250.0 2859700.0 18626000.0 True False 1035023.1291560474 2349364.1920619207 14944562.935934195 1.0 2.2698663690516563 14.438868576898292 19.981231576610025 -6.926901815891178 0.7718099880347332 0.7921354150234098 16.750710568240507 0.9958932759916955 0.38822279318210484 0.09427897517308026 0.08580062692169793 0.34737510585758713 1.1204299212501603 1.1833090447603258e-07 6.926901815891178 15.958575153217097 IPEQILGK(ub)VSIAVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPEQILGKVSIAVIK 15 1 Q02750 Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 1 6771500.0 1954000.0 1677000.0 3140500.0 True False 1891971.3395655253 2346634.8454394694 2317908.837019498 1.0 1.240312047210162 1.2251289374984853 20.851458803572378 -10.00867605058239 4.495927153127605 0.9999918954423475 1.232720492363636 0.9968177841355127 0.006198478672224296 4275663.59483854 0.33748850313137513 359.71350538670526 0.00212190410618889 9.802208802169716e-11 10.00867605058239 0.23272859692128844 IPEQILGK(ub)VSIAVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPEQILGKVSIAVIK 15 1 Q02750 Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 1 9223400.0 2944300.0 2824600.0 3454500.0 True False 3811454.3908297434 2667408.526977046 2825816.4461632613 1.0 0.6998400750628839 0.741401091657321 21.861910181756304 -10.40708848951394 4.99153820502522 1.0003066577532025 0.7206205833600707 0.9836733999946168 0.01696721397472947 5.7965759836747244e-05 6.885343245355795e-06 0.01644626054292817 0.005476144762956304 3.916620660155464e-11 10.40708848951394 -0.27968607439313176 IPEQSVLLLHACAHNPTGVDPRPEQWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPEQSVLLLHACAHNPTGVDPRPEQWK 27 1 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 16607500.0 4712900.0 7085400.0 4809200.0 False True 6178657.539788515 6028285.938672886 4311590.117103863 1.0 0.975662739009682 0.6978198887604056 22.55886198171303 -6.9241256667742315 0.7935256931296305 1.0052677683916231 0.6484680667847861 0.9952523660389799 0.00944476935714736 0.09580472630395497 0.0934772173279711 0.00832080471960397 0.02599907223578761 1.1908973619625712e-07 6.9241256667742315 -0.35679970160683705 IPEQSVLLLHACAHNPTGVDPRPEQWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPEQSVLLLHACAHNPTGVDPRPEQWK 27 1 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 31148300.0 4287700.0 19119000.0 7741600.0 False True 6504754.372858025 15707065.072571175 6211469.366736178 1.0 2.4147053327810575 0.9549122089304988 22.6330631494417 -6.653313088951696 1.996560752772635 1.9155855073761587 0.9610312262080011 0.20763198729113275 0.6033224861087807 0.5004801097645594 3.8276928535710795 0.2447451114436224 0.6684537009180588 2.2217076531365715e-07 6.653313088951696 -0.9545542811681577 IPFNQALVFSNLHSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPFNQALVFSNLHSR 15 0 Q9UHI6 Q9UHI6 DDX20 Probable ATP-dependent RNA helicase DDX20 0 13117900.0 2882500.0 5789900.0 4445500.0 False True 3778985.414169709 4926069.48885344 3985522.304247118 1.0 1.3035428690416788 1.0546540585478252 21.849567519532094 -10.407070646618752 5.87869344030374 0.9999414685302412 1.1790984637945678 0.408430122286371 0.10160843139970072 7.798234531203977e-05 7.865216605321685e-06 0.0984140344255154 0.03279398022044152 3.9167815769767536e-11 10.407070646618752 0.1791569952643266 IPFNQALVFSNLHSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPFNQALVFSNLHSR 15 0 Q9UHI6 Q9UHI6 DDX20 Probable ATP-dependent RNA helicase DDX20 0 9630700.0 2938800.0 1340100.0 5351800.0 False True 2845509.402617789 1875208.9185291776 3950003.0294414773 1.0 0.6590064038460172 1.3881532163652615 21.440255516001763 -6.779542603631187 1.5377369243057115 0.806807148173619 1.3938382660988058 0.7657464353739301 0.14417336695365485 0.2512824893155846 1.1736273439606086 0.0738486811483186 0.17431250545844185 1.6613356952560448e-07 6.779542603631187 0.5870311179251868 IPFNQALVFSNLHSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPFNQALVFSNLHSR 15 0 Q9UHI6 Q9UHI6 DDX20 Probable ATP-dependent RNA helicase DDX20 0 12285500.0 2882500.0 3707400.0 5695600.0 False True 3948238.146633526 3543594.809267677 4350416.584564077 1.0 0.8975129355581377 1.1018627608047071 21.912777581054986 -6.770330153846418 1.5730527006733728 0.9412419990558388 1.1030305195045131 0.7318894931878147 0.04319726344070422 0.2658861399034329 1.2984783427022881 0.02164414572023521 0.05150933731978499 1.6969531257933073e-07 6.770330153846418 0.1617885204486743 IPFNQALVFSNLHSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPFNQALVFSNLHSR 15 0 Q9UHI6 Q9UHI6 DDX20 Probable ATP-dependent RNA helicase DDX20 0 7725500.0 2938800.0 2452600.0 2334100.0 False True 2443742.410914525 2439387.3569970177 2822149.5183409574 1.0 0.9982178752154662 1.1548473790594078 21.22066079143604 -6.904328895917389 0.9335150416129611 0.9942385713807413 1.1728122921685689 0.9885991056361161 0.007839353277610627 0.10828804719034722 0.16000242167261353 0.006243397008539292 0.016626703460938093 1.246439214799535e-07 6.904328895917389 0.17857372078782752 IPGGATLVFEVELLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPGGATLVFEVELLK 15 0 A0A494C1N0;P26885 A0A494C1N0 FKBP2 Peptidyl-prolyl cis-trans isomerase FKBP2 0 82415000.0 18418000.0 36835000.0 27162000.0 False True 27941452.53616137 30261506.45683141 21793418.794472467 1.0 1.0830326883567511 0.7799672821685909 24.735903685397236 -6.833669021755004 1.3113082518063575 1.0442689120483275 0.7711762427079012 0.9130324838538622 0.037709295806022024 0.1763307843557155 0.5916615007909685 0.02256885288632167 0.05194316907474817 1.4666651688398766e-07 6.833669021755004 -0.2730926693404263 IPGGATLVFEVELLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPGGATLVFEVELLK 15 0 A0A494C1N0;P26885 A0A494C1N0 FKBP2 Peptidyl-prolyl cis-trans isomerase FKBP2 0 45044300.0 18418000.0 7366300.0 19260000.0 False True 23842464.07305719 6956358.929501882 15754877.624288432 1.0 0.2917634229493422 0.6607906622408206 24.507030007489686 -10.68415249241689 6.813283857493054 1.0036909901548012 0.47627704259629616 0.7286663743911745 0.15065473957534495 0.008477706060734315 0.0003930053777522776 0.14640730724644607 0.04862360811687725 2.0694145943531647e-11 10.68415249241689 -0.5274139475585051 IPGGGITK(ub)TLYDESCSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPGGGITKTLYDESCSK 17 1 K7ENR6;Q969U7-2;Q969U7;V9GZ55 K7ENR6 PSMG2 Proteasome assembly chaperone 2 1 6184430.0 916330.0 1925600.0 3342500.0 True False 1201317.5037523422 1638307.9859300093 2996650.16352401 1.0 1.3637593565503854 2.4944697418991284 20.196186069703035 -6.950650279269416 0.5516618203376681 0.9845144385825237 2.926985090565499 0.9992513086977747 0.01741145997903151 0.08322573882194635 0.03489029739523709 0.01885788642091318 0.09383172369582486 1.1203396870112968e-07 6.950650279269416 1.942470651982975 up IPGIIIAASAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPGIIIAASAVR 12 0 P33992;B1AHB1;B1AHB2;B1AHA9 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 19810300.0 4336700.0 8190600.0 7283000.0 False True 5685455.696662536 6968594.406708747 6529425.023469064 1.0 1.2256879269676548 1.1484435675581737 22.438844556958408 -10.088435532413085 4.289510008150854 0.9999778610534332 1.1870657472378392 0.8866182970229199 0.03153487776492652 10962933.139298778 0.059563187861581435 2491.0243564255748 0.010795227424480155 8.15763871851534e-11 10.088435532413085 0.18708788618440597 IPGIIIAASAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPGIIIAASAVR 12 0 P33992;B1AHB1;B1AHB2;B1AHA9 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 12364700.0 5473300.0 3006100.0 3885300.0 False True 5299553.087432947 4206451.406604409 2867623.373498439 1.0 0.793737007103362 0.5411066416710788 22.33743927131515 -6.968406710282503 0.29376691495973634 1.0471902501622339 0.27980696167008706 0.9999671459898835 0.0010756272912063583 0.07682324198556895 0.010871308377973392 0.004326366653627279 0.022811635568825286 1.0754575919529671e-07 6.968406710282503 -0.7673832884921468 IPGIIIAASAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPGIIIAASAVR 12 0 P33992;B1AHB1;B1AHB2;B1AHA9 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 63483000.0 13892000.0 19623000.0 29968000.0 False True 21075179.641239714 16121122.334801234 24044811.664559007 1.0 0.7649340413334164 1.1409066054890629 24.329041592717974 -6.737639458093939 1.695319992308962 0.8597608679655391 1.1410181780084097 0.5943868346086922 0.0987710470920259 0.32206370518242045 1.8165764057289804 0.0461078874786838 0.11343995874664481 1.8296184956228938e-07 6.737639458093939 0.2812573100428706 IPGIIIAASAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPGIIIAASAVR 12 0 P33992;B1AHB1;B1AHB2;B1AHA9 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 19051500.0 4336700.0 5992200.0 8722600.0 False True 5940095.184910874 5727444.79044445 6662501.527585961 1.0 0.9642008439516927 1.1216152805951924 22.5020546184813 -6.846917029431822 1.249790568010502 0.9809344687930842 1.1275464449953982 0.9357074990639435 0.01708287973527628 0.1608834139983349 0.48511994681155346 0.010703312565112578 0.02472546250690846 1.4226005444351782e-07 6.846917029431822 0.14661197620231403 IPGIIIAASAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPGIIIAASAVR 12 0 P33992;B1AHB1;B1AHB2;B1AHA9 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 12552400.0 5473300.0 2652400.0 4426700.0 False True 4551291.458302188 2638110.99473982 5352302.503251742 1.0 0.5796400909301335 1.1759964292087686 22.117844546749428 -6.71729884752167 1.7690810304468947 0.74352520117935 1.174927067976185 0.4997485204770483 0.17694967961353603 0.36057719848763936 2.203930756473944 0.07946693007231387 0.20012481877647076 1.9173489169416975e-07 6.71729884752167 0.431401866796835 IPGIIIAASAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPGIIIAASAVR 12 0 P33992;B1AHB1;B1AHB2;B1AHA9 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 47680000.0 13892000.0 20079000.0 13709000.0 False True 17983467.852259196 18961585.99914046 11214102.66621859 1.0 1.0543898515523737 0.6235784309426062 24.100167914810424 -6.875226851682021 1.106030487541211 1.0319870588040752 0.5957044446549942 0.9696291104745616 0.03338326919988631 0.13194424806794963 0.2985266267889352 0.023341228684794345 0.05582282777301778 1.3328250553993921e-07 6.875226851682021 -0.436282614149081 IPGIYVLSLEIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPGIYVLSLEIGK 13 0 A0A2C9F2P4;A0A286YFF7;P50897;Q5T0S4;A0A286YFE3;A0A286YFL8;E9PIA8;E9PK48 A0A2C9F2P4 PPT1 Palmitoyl-protein thioesterase 1 0 4965550.0 2935300.0 1235600.0 794650.0 False True 2842120.5082019875 1728981.5235688777 586507.3260110003 1.0 0.6083420877402149 0.2063625818533792 21.438536296635167 -7.598329634818779 0.36159015085466106 1.0574065654247076 2.2592194850719933e-13 0.999109544165381 0.009668628365398365 0.12291355039757851 0.04780934761714871 0.024632315038054943 0.0714745758316898 2.521566146441895e-08 7.598329634818779 -1.0574065654244817 down IPGIYVLSLEIGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPGIYVLSLEIGK 13 0 A0A2C9F2P4;A0A286YFF7;P50897;Q5T0S4;A0A286YFE3;A0A286YFL8;E9PIA8;E9PK48 A0A2C9F2P4 PPT1 Palmitoyl-protein thioesterase 1 0 26382900.0 9263500.0 11834000.0 5285400.0 False True 14053406.752564354 9722130.24053598 4240738.373326885 1.0 0.6917988222864155 0.3017587441958206 23.74441656755876 -7.150377399431453 0.33475598487898506 1.0510742211593307 2.0470748482226006e-14 0.9999001413265672 0.002855051683120581 0.08227750728396178 0.01669415722961063 0.007754958144370652 0.03754466128081982 7.073308507548901e-08 7.150377399431453 -1.0510742211593103 down IPGIYVLSLEIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPGIYVLSLEIGK 13 0 A0A2C9F2P4;A0A286YFF7;P50897;Q5T0S4;A0A286YFE3;A0A286YFL8;E9PIA8;E9PK48 A0A2C9F2P4 PPT1 Palmitoyl-protein thioesterase 1 0 5017140.0 2935300.0 949640.0 1132200.0 False True 2440832.0058382363 944524.1008312177 1368937.7852986727 1.0 0.38696809062320003 0.5608488343418575 21.218941572069443 -10.837340266296454 10.936289421188308 1.0087532108704 0.47390846248278423 0.9242744300158997 0.070986516367727 0.01468858494418371 0.00021846872040496543 0.06663862543679741 0.022910799641457227 1.4543191864950617e-11 10.837340266296454 -0.5348447483876158 IPGIYVLSLEIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPGIYVLSLEIGK 13 0 A0A2C9F2P4;A0A286YFF7;P50897;Q5T0S4;A0A286YFE3;A0A286YFL8;E9PIA8;E9PK48 A0A2C9F2P4 PPT1 Palmitoyl-protein thioesterase 1 0 19007500.0 9263500.0 7110100.0 2633900.0 False True 11991783.360884177 6714416.68471979 2154557.226096227 1.0 0.5599181108142304 0.17966945876658727 23.515542889651208 -7.8519903602185 0.35081210859787004 1.0771279801416809 8.093386945749041e-12 0.9987424036590751 0.011886898832710515 0.11141025507493495 0.06234925155925684 0.040432836880808384 0.0821055634692523 1.4060787336937051e-08 7.8519903602185 -1.0771279801335876 down IPGLLGVFQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPGLLGVFQK 10 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 4673700.0 1061600.0 1595200.0 2016900.0 False True 1391767.8805490222 1357202.3780408988 1808210.5354709267 1.0 0.975164319430559 1.299218469359723 20.40848718747579 -6.888401710216488 1.0317643947582285 0.9819152561956854 1.326235483602472 0.9798563991502847 0.02089980515651548 0.12045062590092204 0.22948592866683407 0.015465377974743 0.03834109666925962 1.2929993000597538e-07 6.888401710216488 0.34432022740678647 IPGLLGVFQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPGLLGVFQK 10 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 2181390.0 0.0 546490.0 1634900.0 False True 0.0 764706.3069077019 1206670.6440513218 0.0 IPGLLGVFQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPGLLGVFQK 10 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 5149100.0 1061600.0 1834600.0 2252900.0 False True 1454102.2086612817 1753541.30578909 1720811.4199319503 1.0 1.2059271317684654 1.1834184761442692 20.47169724899868 -10.11512103982398 4.691478875093445 0.9999862623027749 1.1946728039591359 0.9900730186525991 0.00918912018870683 1.3204705640406028e-06 2.490609835575671e-07 0.008897955105397275 0.0029657757867535507 7.671476520660293e-11 10.11512103982398 0.194686541656361 IPGLLSPHPLLQLSYTATDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPGLLSPHPLLQLSYTATDR 20 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 17990100.0 4783700.0 8886900.0 4319500.0 False True 6271477.0254166955 7561009.160864884 3872559.575569775 1.0 1.205618569632328 0.6174876444377105 22.580373828347557 -6.81226904566451 1.4051034344787272 1.111764012866402 0.6066692502571881 0.8656291150339666 0.089331004093295 0.20372987107127233 0.7923337410727053 0.04998535573013763 0.11550508280360303 1.540745664468458e-07 6.81226904566451 -0.5050947626092138 IPGLLSPHPLLQLSYTATDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPGLLSPHPLLQLSYTATDR 20 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 71754000.0 31927000.0 22164000.0 17663000.0 False True 30913494.86095624 31014200.783733103 13036530.421358202 1.0 1.0032576686405021 0.42171001628881977 24.88173342851935 -6.905639036466378 0.9249291179665082 1.0205821018488113 0.3531660807645234 0.9891689832905302 0.028451206507690265 0.10737272512659014 0.15493580075948785 0.022802357724472765 0.061195552270832065 1.2426847349698404e-07 6.905639036466378 -0.6674160210842879 down IPGLLSPHPLLQLSYTATDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPGLLSPHPLLQLSYTATDR 20 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 238922000.0 57110000.0 88044000.0 93768000.0 False True 86640045.30025916 72331860.30908817 75234713.7000256 1.0 0.8348548302163897 0.8683595840617659 26.368530661479593 -10.350077787609543 5.743475826090888 1.0000274536626603 0.851607207139078 0.9631740989451865 0.013678258479789327 4.809363064008807e-06 5.442167136392882e-07 0.013246365267981694 0.004414638941445093 4.4660359266046615e-11 10.350077787609543 -0.14842024652358232 IPGLLSPHPLLQLSYTATDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPGLLSPHPLLQLSYTATDR 20 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 28086900.0 4783700.0 4865200.0 18438000.0 False True 6552363.1646316685 4650239.376935068 14083324.142529758 1.0 0.7097041571254963 2.1493503624079775 22.64358388987045 -6.854240045111882 1.214492095218973 0.8443337463488048 2.2117727170978494 0.9462451932708487 0.14412635081427508 0.15285581708828336 0.4317427689512555 0.09275044532848124 0.21528994303191964 1.398813950405169e-07 6.854240045111882 1.3674389707490446 up IPGLLSPHPLLQLSYTATDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPGLLSPHPLLQLSYTATDR 20 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 67421000.0 31927000.0 12364000.0 23130000.0 False True 26548715.10591673 12297392.677938148 27966376.05896335 1.0 0.4632010486713729 1.0533984770031555 24.662138703953627 -6.667323586107555 1.946996617090591 0.6565732791146547 1.0509791963857857 0.2671705450490409 0.22816304190666073 0.4673030851041575 3.412608434101889 0.09443214356332737 0.2531703158802279 2.1511783277306334e-07 6.667323586107555 0.39440591727113106 IPGLLSPHPLLQLSYTATDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPGLLSPHPLLQLSYTATDR 20 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 142564000.0 57110000.0 43773000.0 41681000.0 False True 73930020.80640101 41336994.07044055 34095485.68317578 1.0 0.5591367839417882 0.46118593382329637 26.139656983572042 -13.999999999999998 0.2113804947076194 3.5642470953170857 0.4042591501162111 0.9994908313486882 0.005288028508166382 12.779357506696881 0.14571523967013103 13.618754860276699 0.05746518337743828 1.0000000000000041e-14 13.999999999999998 -3.1599879452008746 IPGMLIIDTPGHESFSNLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPGMLIIDTPGHESFSNLR 19 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 14800500.0 2367600.0 5682000.0 6750900.0 False True 3103946.5278710155 4834267.748262533 6052381.627205452 1.0 1.5574584500263082 1.9498988055560211 21.565672273550312 -7.526399321152308 0.10413307547507306 9.017578724123133e-19 3.3005350603669417 0.9999965144453308 0.000727608102655133 0.13650816267348942 0.009561960617505043 0.11992757276212629 0.1717237938762211 2.9757790288229943e-08 7.526399321152308 3.3005350603669417 IPGMLIIDTPGHESFSNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPGMLIIDTPGHESFSNLR 19 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 11344200.0 3973000.0 2779800.0 4591400.0 False True 3846879.2897102516 3889788.6364654927 3388774.6009524963 1.0 1.01115432627949 0.8809152421332513 21.87525712969209 -6.88606697388544 1.0453476022091297 1.00767180030041 0.8705391504339371 0.9782599947118801 0.00869075003974876 0.12239316316628444 0.24094261070963033 0.006364967152824259 0.015659434458261724 1.299969090350144e-07 6.88606697388544 -0.13713264986647278 IPGMLIIDTPGHESFSNLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPGMLIIDTPGHESFSNLR 19 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 16791900.0 2367600.0 5771900.0 8652400.0 False True 3242965.701984227 5516878.372879129 6608881.321771579 1.0 1.7011830774231116 2.0379128023857596 21.628882335073204 -10.072660404816137 0.16986011766727632 5.483477629464672e-16 2.4410120071135344 0.9996072389129589 0.00856831801373908 1.650467334015164 0.08011308354411471 0.9912543168293032 0.2525873431346467 8.459400667415069e-11 10.072660404816137 2.441012007113534 IPGMLIIDTPGHESFSNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPGMLIIDTPGHESFSNLR 19 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 8846800.0 3973000.0 2031700.0 2842100.0 False True 3303725.5337428264 2020754.8288391232 3436369.9696143353 1.0 0.6116594154689927 1.0401499563195356 21.655662405126368 -6.668075004278164 1.9443190539290671 0.7517149556466358 1.038400277537296 0.27052909379033907 0.16503203362416713 0.4655310350510322 3.39105303909221 0.06837966389130133 0.18314499213858554 2.1474595678195822e-07 6.668075004278164 0.2866853218906602 IPGVPIMYISNHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPGVPIMYISNHR 13 0 G3V5S9;G3V1S4;Q9Y324 G3V5S9 FCF1 rRNA-processing protein FCF1 homolog 0 3430080.0 1129900.0 1317900.0 982280.0 False True 1481309.841967166 1121274.4571339649 880643.0882950986 1.0 0.7569479560366132 0.5945029617339291 20.498442006518456 -8.235598011311204 0.09268005739991426 1.5542574701606344 6.698237000423893e-08 0.9999892454384858 0.0005464189454502526 0.08457542745294787 0.01859347639284563 0.147939492823151 0.15069185453810705 5.8130222957496815e-09 8.235598011311204 -1.5542574031782643 IPGVPIMYISNHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPGVPIMYISNHR 13 0 G3V5S9;G3V1S4;Q9Y324 G3V5S9 FCF1 rRNA-processing protein FCF1 homolog 0 3950900.0 1129900.0 1050300.0 1770700.0 False True 1547654.5643993833 1003894.2731223608 1352497.1287112175 1.0 0.6486552595229504 0.873901166205068 20.561652068041347 -10.100793365091443 4.870508355554734 1.0000099609011062 0.7612782128623539 0.5996229293661689 0.0919562563426708 9.946619984185106e-06 1.8362892577664248e-06 0.08903997686965132 0.029678754115414697 7.928784879407649e-11 10.100793365091443 -0.2387317480387523 IPHLAIHLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPHLAIHLQR 10 0 E7EMB6;E5RIA4;E7ETB3;Q9ULA0-2;Q9ULA0;C9JRG3;C9J1E2;E7EPX3;B9ZVU2;F8WAN0;C9JBE1 E7EMB6 DNPEP Aspartyl aminopeptidase 0 61320400.0 25573000.0 7188400.0 28559000.0 False True 24761199.112952486 10058765.607010782 21078541.148364834 1.0 0.40623095679356985 0.8512730361809793 24.561577845985887 -9.839852640401594 6.334540091678285 1.0000000166212681 0.6287519964872079 0.4812800092730952 0.18168766809472842 4.262482672475366e-08 7.862664645259296e-09 0.1759183360495394 0.058639442728462575 1.445930303260864e-10 9.839852640401594 -0.3712480201340602 IPHLAIHLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPHLAIHLQR 10 0 E7EMB6;E5RIA4;E7ETB3;Q9ULA0-2;Q9ULA0;C9JRG3;C9J1E2;E7EPX3;B9ZVU2;F8WAN0;C9JBE1 E7EMB6 DNPEP Aspartyl aminopeptidase 0 83238000.0 26272000.0 24442000.0 32524000.0 False True 39856544.740472905 20080134.133782372 26095617.144224413 1.0 0.5038102089514978 0.654738570895867 25.248313309113687 -10.834559661471149 10.827930995804904 1.0068017768448232 0.5792743899236906 0.9119783296999698 0.06161624574629989 0.009993555323056638 0.00015269156289315471 0.058929889419894466 0.01988655780260357 1.4636604524853584e-11 10.834559661471149 -0.42752738692113257 IPHLAIHLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPHLAIHLQR 10 0 E7EMB6;E5RIA4;E7ETB3;Q9ULA0-2;Q9ULA0;C9JRG3;C9J1E2;E7EPX3;B9ZVU2;F8WAN0;C9JBE1 E7EMB6 DNPEP Aspartyl aminopeptidase 0 89184000.0 17188000.0 22986000.0 49010000.0 False True 23542868.088234887 21970402.51546281 37434847.392633826 1.0 0.9332084108495732 1.5900716621413344 24.48878675028979 -6.881846279551029 1.0694829164932018 0.9575040462592347 1.6382967668396529 0.9751430029296643 0.046536418602142984 0.12600565732373542 0.2625285035248542 0.033462272162383976 0.08131121523406734 1.312664440174237e-07 6.881846279551029 0.6807927205804182 IPHLAIHLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPHLAIHLQR 10 0 E7EMB6;E5RIA4;E7ETB3;Q9ULA0-2;Q9ULA0;C9JRG3;C9J1E2;E7EPX3;B9ZVU2;F8WAN0;C9JBE1 E7EMB6 DNPEP Aspartyl aminopeptidase 0 47554400.0 25573000.0 8191400.0 13790000.0 False True 21265082.575989246 8147271.3023344 16673425.24224402 1.0 0.38312906960133875 0.784075264352383 24.341983121420164 -10.054522553931912 5.540544768866475 1.0000024046304528 0.5836021669767414 0.5898414198889195 0.1636855985758084 4.861934950319575e-06 8.299171037845443e-07 0.15848881313409144 0.05282929977473945 8.820179956822918e-11 10.054522553931912 -0.41640023765371137 IPHLAIHLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPHLAIHLQR 10 0 E7EMB6;E5RIA4;E7ETB3;Q9ULA0-2;Q9ULA0;C9JRG3;C9J1E2;E7EPX3;B9ZVU2;F8WAN0;C9JBE1 E7EMB6 DNPEP Aspartyl aminopeptidase 0 114990000.0 26272000.0 56771000.0 31947000.0 False True 34009621.898542576 53611643.94428021 26132973.803901445 1.0 1.5763669500417952 0.7683994218418915 25.019439631206136 -6.7151367122778725 1.7765604303992344 1.3524524129868098 0.7699655553490151 0.4896313744073315 0.24269184220497667 0.36483178904680547 2.2475322272188656 0.10857736278179035 0.27416749393320866 1.9269182399300506e-07 6.7151367122778725 -0.5824868576377947 IPIFSAAGLPHNEIAAQICR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPIFSAAGLPHNEIAAQICR 20 0 P21281;C9JL73;P15313;C9JNS9 P21281 ATP6V1B2;ATP6V1B1 V-type proton ATPase subunit B, brain isoform;V-type proton ATPase subunit B, kidney isoform 0 9604000.0 1016100.0 2582100.0 6005800.0 False True 1391779.6290700175 2468014.284137147 4587353.733333616 1.0 1.773279499561483 3.2960345427665656 20.408499365843802 -6.9603470673509005 0.4305143188007287 0.9398427676463192 4.187916069350411 0.9997828561624504 0.014055785998926767 0.07957737265281102 0.02067491716311052 0.019866215191851496 0.12642077173164984 1.0956022933172805e-07 6.9603470673509005 3.2480733017040917 IPILSTFLTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPILSTFLTAR 11 0 C9J5H8;Q9UBB6-2;Q9UBB6;Q9UBB6-3 C9J5H8 NCDN Neurochondrin 0 2482140.0 422070.0 1351900.0 708170.0 False True 553337.8573316936 1150201.7896649276 634895.3616463117 1.0 2.0786609382040693 1.1473918750253322 19.077801105458324 -6.610519232989339 2.1519111447353025 1.7204188476403217 1.1507447469671117 0.05192175749871575 0.46498825081096967 0.6112608660827792 5.36469171466307 0.17839644024562207 0.516149039792536 2.4517758730530197e-07 6.610519232989339 -0.56967410067321 IPILSTFLTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPILSTFLTAR 11 0 C9J5H8;Q9UBB6-2;Q9UBB6;Q9UBB6-3 C9J5H8 NCDN Neurochondrin 0 2675820.0 813110.0 996390.0 866320.0 False True 787298.2681239124 1394253.723105206 639404.8029570872 1.0 1.7709345740434999 0.8121506535010586 19.586550779065913 -6.692687201988284 1.8568497132498465 1.4821197613782973 0.8153609503711088 0.38293374241384803 0.32587834915257297 0.4109798283337335 2.7493780364539755 0.1402888494171829 0.36409170659470264 2.0291436719707783e-07 6.692687201988284 -0.6667588110071885 IPILSTFLTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPILSTFLTAR 11 0 C9J5H8;Q9UBB6-2;Q9UBB6;Q9UBB6-3 C9J5H8 NCDN Neurochondrin 0 4233770.0 422070.0 1152600.0 2659100.0 False True 578120.6850128743 1101674.320861499 2031075.3458835492 1.0 1.9056130483152762 3.5132376310636917 19.141011166981215 -6.962308126382651 0.40158272892874725 0.9131548701514702 4.564546702563191 0.9998464561298555 0.012878029439809662 0.07888668932537848 0.018158848534274567 0.020682235842517417 0.13461396601368156 1.0906662481189768e-07 6.962308126382651 3.6513918324117203 IPISLVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPISLVLR 8 0 O95747;C9JIG9 O95747 OXSR1 Serine/threonine-protein kinase OSR1 0 26633700.0 8650700.0 8645900.0 9337100.0 False True 11341151.473497968 7355965.421454241 8370986.4597876 1.0 0.6486083391658845 0.7381072794370962 23.43506378956838 -9.877357464332553 6.332837446501057 1.0000000238297353 0.6933578093014464 0.9399467529660779 0.036537789364211204 1.230207152049696e-08 2.2059497848028113e-09 0.035377565328047665 0.011792520809544916 1.3263023394317096e-10 9.877357464332553 -0.3066422145282889 IPISLVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPISLVLR 8 0 O95747;C9JIG9 O95747 OXSR1 Serine/threonine-protein kinase OSR1 0 17687700.0 7047700.0 5101300.0 5538700.0 False True 6823974.621215939 7138275.6929280665 4087948.312561662 1.0 1.0460583588243362 0.5990567872061116 22.702180850518186 -6.88148650436884 1.0715218471252586 1.0291445033165687 0.5664671305446671 0.9748628282778562 0.03182754061394623 0.12631930314291595 0.26442418041289234 0.022850316748966863 0.05547037065715684 1.3137523189677285e-07 6.88148650436884 -0.4626773727719016 IPISLVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPISLVLR 8 0 O95747;C9JIG9 O95747 OXSR1 Serine/threonine-protein kinase OSR1 0 29481400.0 7250400.0 10207000.0 12024000.0 False True 10999386.875240749 8385481.102345005 9647451.129693579 1.0 0.7623589566815258 0.8770898995660993 23.390919771897618 -10.088351691050322 4.6048770422184155 1.0000114263743962 0.8197244281186017 0.7670049070840763 0.04683871131372876 65132378.09800836 1.517810154268834 7891.12321096163 0.016034136716713682 8.159213717965054e-11 10.088351691050322 -0.18028699825579453 IPISLVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPISLVLR 8 0 O95747;C9JIG9 O95747 OXSR1 Serine/threonine-protein kinase OSR1 0 36510200.0 8650700.0 9095500.0 18764000.0 False True 11849097.566377321 8693630.735203672 14332329.656710498 1.0 0.7336955988844656 1.2095714105164876 23.498273851091273 -6.754852499557835 1.6319707998970343 0.8443292514408803 1.210874246646329 0.6695667217577919 0.11194023968853699 0.2916469214088385 1.5296404755912216 0.054153870322007525 0.13080389310102028 1.758520763032746e-07 6.754852499557835 0.3665449952054486 IPISLVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPISLVLR 8 0 O95747;C9JIG9 O95747 OXSR1 Serine/threonine-protein kinase OSR1 0 19042000.0 7047700.0 5218000.0 6776300.0 False True 5860474.816048151 5189889.598308092 8193192.999928797 1.0 0.8855749339791124 1.3980425233622367 22.482586125952462 -6.8480949009825025 1.2441898601702381 0.9390218517253843 1.417794664299961 0.9374931038100301 0.054911663652949694 0.15956726899627088 0.4762844577419106 0.03455076397487743 0.07986414619997888 1.4187474665402428e-07 6.8480949009825025 0.4787728125745767 IPISLVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPISLVLR 8 0 O95747;C9JIG9 O95747 OXSR1 Serine/threonine-protein kinase OSR1 0 28655700.0 7250400.0 13515000.0 7890300.0 False True 9385785.726750659 12762878.369360195 6454346.361314796 1.0 1.3598092627433847 0.6876724601669847 23.162046093990067 -6.761300049320966 1.6076881056690229 1.2086600482359195 0.685067266894049 0.6962139605896196 0.1513654913912222 0.28073687475472764 1.4304112762870098 0.07427731074419792 0.1782637275022255 1.7326065451827074e-07 6.761300049320966 -0.5235927813418706 IPK(ub)HLTDAYFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPKHLTDAYFK 11 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 12461900.0 3752900.0 4613200.0 4095800.0 True False 4920088.243135301 3924928.542112758 3672005.9056878537 1.0 0.7977353958211971 0.7463292778968302 22.230252760252924 -13.999999999999998 0.19234594046025158 2.0931923768817846 0.7103080262972201 0.9994882862614147 0.002476889576134257 12.389895370870052 0.13908180624664734 5.080520987112406 0.03470433612856762 1.0000000000000041e-14 13.999999999999998 -1.3828843505845645 IPK(ub)HLTDAYFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPKHLTDAYFK 11 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 32958000.0 6089600.0 9499400.0 17369000.0 True False 9238368.409393417 7804157.8508490445 13936009.536896873 1.0 0.844754994065176 1.5084925085610328 23.139206648722542 -6.845078752728288 1.258573756414072 0.9173839033544825 1.5326159811674462 0.932841028815384 0.07346219705405992 0.16295081976462455 0.4991794814007026 0.04572599202368162 0.10553423898286224 1.4286348737190328e-07 6.845078752728288 0.6152320778129637 IPK(ub)HLTDAYFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPKHLTDAYFK 11 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 17895400.0 3752900.0 6471800.0 7670700.0 True False 5140448.548309094 6185854.476619334 5859038.643025433 1.0 1.2033686201672258 1.1397913213143067 22.293462821775815 -10.083929827590493 4.414432756604192 0.9999847539576386 1.171579970698199 0.9066387749627226 0.025955323613717635 3.961670807523994e-06 8.220812440321171e-07 0.02513340481177153 0.008377044668854408 8.242712883138997e-11 10.083929827590493 0.17159521674056044 IPK(ub)HLTDAYFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPKHLTDAYFK 11 1 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 28171300.0 6089600.0 8744700.0 13337000.0 True False 7883107.243961819 8258049.757790908 10909802.849176254 1.0 1.0475627823173763 1.3839470289501359 22.91033297081499 -6.9324625236557145 0.7262875557323435 0.9953230409221145 1.4575466216609245 0.9970006269377782 0.009359075356182047 0.09137889421403578 0.07156103868082786 0.008655113897395351 0.030035375009667103 1.1682545370833799e-07 6.9324625236557145 0.46222358073881 IPLLLTSLSFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPLLLTSLSFK 11 0 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 0 21781500.0 5629200.0 7863900.0 8288400.0 False True 8539907.949644873 6460525.604068858 6650194.107065224 1.0 0.7565099813912531 0.7787196473636192 23.025789088665658 -10.778233333687226 6.983697611942681 1.006568362232266 0.7676148143775142 0.9931960113143109 0.009067058164991877 0.0009429984350741503 2.994478392756747e-05 0.008927959736671723 0.0029263804393422953 1.6663516901147996e-11 10.778233333687226 -0.23895354785475187 IPLLLTSLSFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPLLLTSLSFK 11 0 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 0 9166730.0 567430.0 2557300.0 6042000.0 False True 777224.2052191718 2444310.0301397825 4615004.038896019 1.0 3.144922679615342 5.937802770301807 19.56797130614479 -6.9675017218490565 0.3121461844975363 0.5804941417564332 8.591285707451341 0.9999558191096355 0.013437489726252009 0.07712196151972682 0.011917510564102628 0.04376709862390908 0.24744430404434223 1.0777009809204944e-07 6.9675017218490565 8.010791565694907 IPLLLTSLSFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPLLLTSLSFK 11 0 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 0 15451200.0 5629200.0 4863400.0 4958600.0 False True 7287110.368121037 4592747.514727809 4056185.6795325335 1.0 0.6302563406778806 0.5566247078234401 22.796915410758107 -13.999999999999998 0.22686709767182406 3.300748393106941 0.519740253316771 0.9995056785416861 0.004313198361608105 13.195578064205769 0.15083551988333718 13.65177902349614 0.03898024015954043 1.0000000000000041e-14 13.999999999999998 -2.7810081397901696 IPLLSDLTHQISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPLLSDLTHQISK 13 0 Q13162;H7C3T4;A6NJJ0 Q13162 PRDX4 Peroxiredoxin-4 0 30001300.0 4451300.0 12272000.0 13278000.0 False True 5835697.406450516 10441065.435881346 11904119.931569735 1.0 1.7891718347733838 2.0398795726473855 22.4764736476569 -10.692220411290432 0.235500334719446 1.0099885404128602e-13 2.1849837598781314 0.9992286137931832 0.012306439615217594 2.4685413610606366 0.12133819525210272 1.5299417912593858 0.12381811007990882 2.0313258194352417e-11 10.692220411290432 2.1849837598780306 IPLLSDLTHQISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPLLSDLTHQISK 13 0 Q13162;H7C3T4;A6NJJ0 Q13162 PRDX4 Peroxiredoxin-4 0 19006900.0 8796500.0 4171400.0 6039000.0 False True 8517259.92246067 5837061.77356363 4457204.733883376 1.0 0.6853215502054656 0.5233143962331577 23.02195794671397 -13.999999999999096 0.08470141259841704 2.652531919453598 0.07895137809230099 0.9998665642204628 0.0022860822073426314 12.212716828801861 0.08322059768645941 3.705954634775189 0.40135356899754604 1.000000000002082e-14 13.999999999999096 -2.573580541361297 IPLLSDLTHQISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPLLSDLTHQISK 13 0 Q13162;H7C3T4;A6NJJ0 Q13162 PRDX4 Peroxiredoxin-4 0 29039200.0 4451300.0 8056900.0 16531000.0 False True 6097065.901859427 7700919.517394593 12626718.266631927 1.0 1.2630533508004298 2.0709499404920564 22.53968370917979 -6.950922121744756 0.548628988389654 0.9887351516108281 2.3831326540104736 0.9992716608371955 0.012297877557741798 0.0831176125326021 0.03444651052179408 0.01337145814971887 0.06700467749793625 1.1196386405338955e-07 6.950922121744756 1.3943975023996455 up IPLLSDLTHQISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPLLSDLTHQISK 13 0 Q13162;H7C3T4;A6NJJ0 Q13162 PRDX4 Peroxiredoxin-4 0 13132800.0 8796500.0 2299400.0 2036900.0 False True 7314679.501024108 2287012.6758048343 2462806.372438492 1.0 0.312660681234856 0.3366936818070677 22.802363222148248 -10.246574478191569 5.521665261038439 1.0000467033349933 0.32467718152098557 0.9990510523812969 0.009811431398431018 5.641332261390842e-06 7.697560302760194e-07 0.00950053104194384 0.003166625867365901 5.66794362277542e-11 10.246574478191569 -0.6753695218140078 IPLLSDLTHQISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPLLSDLTHQISK 13 0 Q13162;H7C3T4;A6NJJ0 Q13162 PRDX4 Peroxiredoxin-4 0 17588100.0 2138600.0 11940000.0 3509500.0 False True 2768459.858108377 11275528.503896464 2870807.0105109178 1.0 4.0728524456918676 1.0369689855183495 21.4006521726706 -6.643368262741302 2.032034323418999 3.00432951695672 1.0496135614522373 0.1676534627899332 1.3136844023540366 0.5249972504543078 4.147086067759767 0.525680476187277 1.4549769911987158 2.273169065276491e-07 6.643368262741302 -1.9547159555044826 IPLNPYLNLHSLLPASNLAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPLNPYLNLHSLLPASNLAGK 21 0 A0A087WZ13;E9PAU2;Q8IY67-2 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 0 25576800.0 4795800.0 17763000.0 3018000.0 False True 6287340.242593266 15112829.63963168 2705726.310700212 1.0 2.4036920313697334 0.430345139009721 22.58401840672399 -6.7156892723140205 1.7750263631877352 1.8578936144218716 0.43417702805095454 0.49205693026002084 0.5910101782412508 0.3637375747089928 2.2373342328105674 0.2646329978847355 0.6676695498725449 1.9244681490310178e-07 6.7156892723140205 -1.4237165863709171 IPLNPYLNLHSLLPASNLAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPLNPYLNLHSLLPASNLAGK 21 0 A0A087WZ13;E9PAU2;Q8IY67-2 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 0 56651000.0 22557000.0 13201000.0 20893000.0 False True 21840940.38207755 18472228.142305553 15420496.523435257 1.0 0.8457615752416812 0.7060362902729755 24.380531638388383 -6.972301764142804 0.19555782777842318 1.0880877486227165 0.459870724732277 0.9999952067442017 0.0002627876583040599 0.0755627533397313 0.006280181093731845 0.004706708241581598 0.015004602979851898 1.0658552675395855e-07 6.972301764142804 -0.6282170238904394 IPLNPYLNLHSLLPASNLAGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPLNPYLNLHSLLPASNLAGK 21 0 A0A087WZ13;E9PAU2;Q8IY67-2 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 0 34372700.0 7023600.0 17458000.0 9891100.0 False True 10655314.693939768 14342483.500023406 7936119.749576861 1.0 1.3460403481260599 0.7448038821500547 23.34506986649986 -6.750628873537063 1.6474657747588548 1.2033220582740158 0.7435481340744969 0.6516809449092517 0.14541343456497804 0.2989562603653711 1.5966319781662504 0.06971909169820396 0.1691509175473336 1.7757062629653892e-07 6.750628873537063 -0.4597739241995189 IPLNPYLNLHSLLPASNLAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPLNPYLNLHSLLPASNLAGK 21 0 A0A087WZ13;E9PAU2;Q8IY67-2 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 0 35339700.0 4795800.0 5383900.0 25160000.0 False True 6568936.861621878 5146021.495823551 19217726.18646537 1.0 0.7833872671068712 2.925545882278505 22.647228468246883 -6.881997654014812 1.0686495986448359 0.8618655569297512 3.083263456905884 0.9752591352152621 0.15144679889571538 0.1258728205552289 0.2617471896726678 0.10896921624129931 0.26489284896377585 1.3122069873198133e-07 6.881997654014812 2.221397899976133 up IPLNPYLNLHSLLPASNLAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPLNPYLNLHSLLPASNLAGK 21 0 A0A087WZ13;E9PAU2;Q8IY67-2 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 0 44538100.0 22557000.0 8399100.0 13582000.0 False True 18757144.944534834 8353852.381209171 16421933.403927356 1.0 0.44536907967132744 0.8755028258558147 24.16093691382266 -9.884358320790053 6.569112016218684 1.000000015927461 0.6604359527635622 0.45383556246322054 0.17560136655069206 4.088329486772234e-08 6.942238305612717e-09 0.1700252996562109 0.056675097351832675 1.305093657864052e-10 9.884358320790053 -0.33956406316389875 IPLNPYLNLHSLLPASNLAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPLNPYLNLHSLLPASNLAGK 21 0 A0A087WZ13;E9PAU2;Q8IY67-2 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 0 25308100.0 7023600.0 10266000.0 8018500.0 False True 9092188.655854283 9694688.07546074 6559215.276757885 1.0 1.0662656091301537 0.7214121401379561 23.11619618859231 -6.856912009754157 1.2012015116509585 1.0356990988105486 0.7056682115236499 0.9497781502510905 0.03348446942809303 0.15001870248485724 0.4130791178162258 0.021766995741018622 0.05064814153529018 1.3902342711355536e-07 6.856912009754157 -0.33003088728689867 IPLNPYLNLHSLLPASNLAGK(ub)EAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPLNPYLNLHSLLPASNLAGKEAR 24 1 A0A087WZ13;E9PAU2;Q8IY67-2 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 1 23422700.0 5244000.0 6210700.0 11968000.0 True False 7955531.387752739 5102352.060579415 9602519.55423926 1.0 0.6413590509408721 1.2070242811211833 22.923526867557637 -6.735389494185908 1.7035980969525146 0.7854763953548474 1.2070316126393075 0.5840450629148006 0.1507112840209124 0.32623086512379446 1.8571748054015789 0.07003914606073329 0.17274583760289014 1.8391218571241228e-07 6.735389494185908 0.4215552172844601 IPLNPYLNLHSLLPASNLAGK(ub)EAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPLNPYLNLHSLLPASNLAGKEAR 24 1 A0A087WZ13;E9PAU2;Q8IY67-2 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 1 26785700.0 5244000.0 5782700.0 15759000.0 True False 6788461.374693869 5460887.661598163 12891023.700994873 1.0 0.8044367287638027 1.898961044258163 22.694653189650086 -6.860711399636824 1.1822287158199247 0.8937003284656508 1.9526648530515789 0.9544943976104596 0.10166929343456746 0.14606483830822306 0.3875337776062828 0.06705805186295631 0.1566511519458995 1.37812496577727e-07 6.860711399636824 1.058964524585928 IPLNTEQK(ub)ALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPLNTEQKALK 11 1 J3KT10;Q9BW27;Q9BW27-3;J3QL54;F5H0W7;J3QLD4;Q9BW27-2;J3QLH0 J3KT10 NUP85 Nuclear pore complex protein Nup85 1 6338280.0 341900.0 459480.0 5536900.0 True False 331046.5716465982 642952.7601565457 4086619.786560501 1.0 1.9421822040281278 12.344546467386726 18.336674664150024 -6.924632567542929 0.789616149802784 0.8064758267855144 14.214760871968181 0.9953738000941189 0.3496172659164791 0.09552233343365531 0.09204971917295182 0.3088734973002507 0.970491413692638 1.1895081786875553e-07 6.924632567542929 13.408285045182668 up IPLNTEQK(ub)ALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPLNTEQKALK 11 1 J3KT10;Q9BW27;Q9BW27-3;J3QL54;F5H0W7;J3QLD4;Q9BW27-2;J3QLH0 J3KT10 NUP85 Nuclear pore complex protein Nup85 1 18789800.0 1145700.0 5464100.0 12180000.0 True False 1738110.661889458 4488988.663791837 9772617.661316363 1.0 2.582682887930718 5.622552047803899 20.72908850779219 -6.960828324280818 0.423598916300971 0.8707257485340216 7.449860259293808 0.9997996956618922 0.027147360967284963 0.07940655782911163 0.02004781810575919 0.03942193123676521 0.25280135461206915 1.0943888904653894e-07 6.960828324280818 6.579134510759786 IPLNTEQK(ub)ALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPLNTEQKALK 11 1 J3KT10;Q9BW27;Q9BW27-3;J3QL54;F5H0W7;J3QLD4;Q9BW27-2;J3QLH0 J3KT10 NUP85 Nuclear pore complex protein Nup85 1 4565570.0 341900.0 730470.0 3493200.0 True False 284304.9987381506 726534.8131230568 4223611.969268084 1.0 2.555476746267859 14.855918777418674 18.1170799395843 -6.930312618637479 0.7442263228196003 0.8150986227944644 17.401317002145895 0.9965992375278712 0.3614272541152315 0.09247593170630997 0.07688863846539445 0.3298911124887334 1.1110717824546121 1.1740521315581718e-07 6.930312618637479 16.58621837935143 IPLNTEQK(ub)ALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPLNTEQKALK 11 1 J3KT10;Q9BW27;Q9BW27-3;J3QL54;F5H0W7;J3QLD4;Q9BW27-2;J3QLH0 J3KT10 NUP85 Nuclear pore complex protein Nup85 1 10270200.0 1145700.0 3031300.0 6093200.0 True False 1483131.2351233352 2862605.490273142 4984300.121511642 1.0 1.9301093675874823 3.360660205566471 20.50021482988464 -6.964837584379705 0.36082858361623177 0.8778904037886267 4.4619656838048405 0.9999097586611576 0.009223363491744073 0.0780161145136332 0.0150545213070627 0.01916108914359008 0.1221267786862975 1.0843323522483303e-07 6.964837584379705 3.5840752800162137 IPMPDFDLHLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 IPMPDFDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 34142730.0 7946800.0 15232200.0 10963730.0 False True 10418331.756920679 12959615.134650573 9829308.391124338 1.0 1.2439242133023622 0.9434627942803736 23.31262094771089 -6.690772439387385 1.863707521349468 1.15281351484084 0.9444921303395044 0.37405262918715354 0.1031464763364224 0.4149961643030837 2.795327781541674 0.044265641309025376 0.11515715715973529 2.0381097219626177e-07 6.690772439387385 -0.20832138450133564 IPMPDFDLHLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 IPMPDFDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 36998200.0 15622400.0 7269200.0 14106600.0 False True 15126475.463269416 10171829.468377223 10411658.271071251 1.0 0.672452052236278 0.6883069553349138 23.850572536497783 -10.27094796145964 8.376035875098951 1.0000002500740164 0.6803795037897988 0.9981578763074229 0.006472737085488269 3.0232601929520594e-08 2.6312849097357536e-09 0.006267205683568827 0.0020890669113729286 5.3586086221239835e-11 10.27094796145964 -0.31962074628421755 IPMPDFDLHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPMPDFDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 40611600.0 9289600.0 20277000.0 11045000.0 False True 14093002.360729957 16658410.92507589 8861950.908804536 1.0 1.1820342109282849 0.6288192311312097 23.748475659075183 -6.818069353296296 1.3803759974938767 1.09831126114469 0.6172519863544341 0.8798373529220741 0.07980015827812574 0.19601088275082038 0.7344240756170403 0.04543651906049977 0.10477302251485864 1.5203047300469096e-07 6.818069353296296 -0.4810592747902558 IPMPDFDLHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 IPMPDFDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 40890800.0 7946800.0 12386900.0 20557100.0 False True 10884946.71419508 11839605.799999403 15701936.36676418 1.0 1.087704525421273 1.4425368152043643 23.37583100923378 -6.944613872564944 0.6151496669511131 0.996100126733901 1.5527835998849215 0.9987078463530346 0.006877360233255711 0.08572349717834163 0.045489170709569524 0.0069570167923395645 0.02997555387509098 1.1360203926231697e-07 6.944613872564944 0.5566834731510205 IPMPDFDLHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPMPDFDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 26508500.0 13921000.0 6744100.0 5843400.0 False True 11575928.30486632 6707768.194700964 7065227.923171041 1.0 0.5794583395857017 0.6103379130467611 23.46462455593689 -9.978940586714247 5.301678436711523 1.000001563995697 0.5948981263147086 0.9956610270303786 0.012606533081061456 2.3304406630328614e-07 4.4874449434355553e-08 0.012206270270993842 0.00406874105559435 1.049686020229809e-10 9.978940586714247 -0.40510343768098833 IPMPDFDLHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPMPDFDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 29244100.0 9289600.0 11471000.0 8483500.0 False True 12025570.325392105 10832628.766180607 6939590.048060792 1.0 0.900799585638563 0.5770695160634322 23.519601981167632 -6.949544862050141 0.5638170900658412 1.0041523834723463 0.4581433935125305 0.9991650877729998 0.005218093733866251 0.08366899437863254 0.036722541864385776 0.005568058422642207 0.026933631344560217 1.1231949391180633e-07 6.949544862050141 -0.5460089899598157 IPNFCVLLHGSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPNFCVLLHGSLK 13 0 B4DVT3;B4DJL6;Q96SY0-4;Q96SY0-3;Q96SY0;H3BRY6 B4DVT3 VWA9 von Willebrand factor A domain-containing protein 9 0 32872100.0 9750200.0 9397900.0 13724000.0 False True 14791766.23510046 7720771.318872153 11011445.384557104 1.0 0.5219641249163992 0.7444307332566711 23.818290994301126 -10.082487578209136 5.208504745872128 1.0000061032978849 0.6331974290859246 0.7837704376201103 0.09082161254234143 6.4368734649864965e-06 1.133923899870425e-06 0.08793911142983812 0.029312549404042394 8.270131626507315e-11 10.082487578209136 -0.3668086742119603 IPNFCVLLHGSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPNFCVLLHGSLK 13 0 B4DVT3;B4DJL6;Q96SY0-4;Q96SY0-3;Q96SY0;H3BRY6 B4DVT3 VWA9 von Willebrand factor A domain-containing protein 9 0 24563200.0 9750200.0 7787400.0 7025600.0 False True 12621826.105175477 7354024.344325234 5747012.888743553 1.0 0.5826434529398069 0.4553234088993698 23.589417316393575 -13.999999999999998 0.16631026283674763 3.085190154616654 0.3384845044459365 0.9995212078733267 0.0050903473737153844 12.057760187909444 0.12905989228169368 8.109373087315138 0.10739614682824825 1.0000000000000041e-14 13.999999999999998 -2.7467056501707177 IPNFWVTTFVNHPQVSALLGEEDEEALHYLTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPNFWVTTFVNHPQVSALLGEEDEEALHYLTR 32 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 0 7388168800.0 2597006500.0 2353579200.0 2437583100.0 False True 3939848727.106773 1933564603.161776 1955793731.8543715 1.0 0.49077128008965176 0.49641340754994123 31.87549309157589 -9.879723440675376 5.867085287294965 1.0000001354385022 0.49359234381966705 0.9999069087586048 0.0023033888921784817 4.080273413568558e-09 7.760173267684114e-10 0.0022302473021541184 0.0007434155679876608 1.319096473608195e-10 9.879723440675376 -0.5064077916188352 IPNFWVTTFVNHPQVSALLGEEDEEALHYLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPNFWVTTFVNHPQVSALLGEEDEEALHYLTR 32 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 0 5008696500.0 2597006500.0 483590000.0 1928100000.0 False True 3361876108.9013996 456677791.3902254 1577205583.9766626 1.0 0.13584016084978798 0.4691444696015479 31.64661941366834 -10.538429444380704 6.275575251093269 1.000884969373554 0.30249231545126565 0.8537845060400003 0.13607091425214557 0.0016866625139024035 0.00012405450583876068 0.13189558093531473 0.043916698733481425 2.8944800170113368e-11 10.538429444380704 -0.6983926539222883 IPNIYAIGDVVAGPMLAHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPNIYAIGDVVAGPMLAHK 19 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 3642620.0 0.0 1915700.0 1726920.0 False True 0.0 1629885.0273401123 1548234.8841863524 0.0 IPNIYAIGDVVAGPMLAHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPNIYAIGDVVAGPMLAHK 19 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 11838900.0 4789400.0 4839100.0 2210400.0 False True 4637363.11858501 6771377.865573128 1631429.9294213988 1.0 1.4601784877349147 0.3518012041979568 22.14487326754213 -6.793912947287883 1.4804579611846012 1.255879820349196 0.3386654996150535 0.813860143686328 0.19615737752244297 0.2295369458998121 0.9936985955765859 0.10426608575351808 0.24345706158891406 1.6072633906893323e-07 6.793912947287883 -0.9172143207341426 down IPNIYAIGDVVAGPMLAHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPNIYAIGDVVAGPMLAHK 19 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 9487000.0 0.0 3613100.0 5873900.0 False True 0.0 3453461.2950760745 4486605.796767846 0.0 IPNIYAIGDVVAGPMLAHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPNIYAIGDVVAGPMLAHK 19 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 8289500.0 4789400.0 1351000.0 2149100.0 False True 3982598.306395133 1343721.894847495 2598466.8736843118 1.0 0.33739829916810543 0.6524551746812562 21.925278542976407 -10.537351032589346 6.399186854216535 1.000553066290097 0.4949267369248887 0.7740954636119243 0.12862143082712996 0.0010159293127368445 7.344939134900338e-05 0.12466522195051147 0.04151238829657029 2.9016763324153664e-11 10.537351032589346 -0.5056263293652083 IPPLFPQKPLSLFQTSHTLHLSHLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPPLFPQKPLSLFQTSHTLHLSHLNR 26 1 Q8N163;Q8N163-2;H0YC69 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 0 109402000.0 26065000.0 28573000.0 54764000.0 False True 39542510.60674589 23473924.908132024 43939871.39608606 1.0 0.593637696442254 1.1112059078158276 25.23690113681926 -6.697326069310636 1.8404850655830336 0.7470035287143839 1.1095865581966282 0.40483741917425264 0.17161646416755474 0.4011237912610734 2.6397359276234993 0.07444379912001568 0.1920785970444684 2.007584947161175e-07 6.697326069310636 0.3625830294822443 IPPLFPQKPLSLFQTSHTLHLSHLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPPLFPQKPLSLFQTSHTLHLSHLNR 26 1 Q8N163;Q8N163-2;H0YC69 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 0 108752500.0 26065000.0 48886500.0 33801000.0 False True 33741656.31796261 46165923.30031277 27649564.827547923 1.0 1.3682174599038879 0.8194489496008671 25.00802745891171 -6.72591172355459 1.738188681834024 1.2225937798179976 0.82001413662187 0.5402068499327546 0.15484564409973564 0.3439474813683247 2.033873933561793 0.07065294170783068 0.17613431683237823 1.8796988531337603e-07 6.72591172355459 -0.4025796431961276 IPPPVIMVQNVSFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPPPVIMVQNVSFK 14 0 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 0 9928100.0 2530000.0 4436000.0 2962100.0 False True 3316854.500554851 3774166.0913925716 2655610.3064695518 1.0 1.1378750833843392 0.800641181584937 21.66138429657463 -6.795676813158996 1.4733387401198024 1.076492209387921 0.7964590923645858 0.8192832678711888 0.0588501435226558 0.2269770035593131 0.973081702874971 0.03142936530836151 0.07329911805713725 1.6007488070516837e-07 6.795676813158996 -0.2800331170233352 IPPPVIMVQNVSFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPPPVIMVQNVSFK 14 0 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 0 6193800.0 2211000.0 978200.0 3004600.0 False True 2140813.015240212 1368800.3612456094 2217605.1239321074 1.0 0.639383426530608 1.0358705352336803 21.029727361420218 -6.6673460338396175 1.9473084360674477 0.7692916769886968 1.0342330873552954 0.2671717266055055 0.15327722390367482 0.467206870177718 3.4131401888900568 0.06343381386194653 0.17003531704475386 2.1510671409005566e-07 6.6673460338396175 0.2649414103665986 IPPPVIMVQNVSFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPPPVIMVQNVSFK 14 0 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 0 8490200.0 2530000.0 2872100.0 3088100.0 False True 3465409.3706792067 2745201.1252353876 2358754.3814158854 1.0 0.7921722462178657 0.6806567793615618 21.724594358097523 -13.999999998352807 0.07686637807845927 2.1432082913805854 0.32744401255170097 0.9998992890010566 0.0013280133862415748 12.289827677904242 0.07708458774641368 2.425109105040844 0.3220786656557243 1.0000000037928011e-14 13.999999998352807 -1.8157642788288846 IPQCSQLQEDVDPQK(ub)VAFLLHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPQCSQLQEDVDPQKVAFLLHK 22 1 Q8N0S6-2;Q8N0S6;Q8N0S6-3 Q8N0S6-2 CENPL Centromere protein L 1 11152200.0 2482600.0 4481800.0 4187800.0 True False 3254712.6415326027 3813132.9099195735 3754486.6282141656 1.0 1.1715728329626107 1.153553951370105 21.634098742842106 -10.089093353269888 4.4820675063586375 0.9999866309490891 1.1625633921740974 0.9908696335113756 0.007356177635056046 9.877477515720954e-07 2.0074386761524787e-07 0.00712317688846722 0.002374196118644365 8.145291790207325e-11 10.089093353269888 0.1625767612250083 IPQCSQLQEDVDPQK(ub)VAFLLHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPQCSQLQEDVDPQKVAFLLHK 22 1 Q8N0S6-2;Q8N0S6;Q8N0S6-3 Q8N0S6-2 CENPL Centromere protein L 1 24710900.0 9081900.0 11637000.0 3992000.0 True False 8793600.055680726 16283714.786153316 2946375.442567058 1.0 1.8517688640653978 0.3350590684032394 23.068022487727912 -6.7542909413557135 1.6337345423567764 1.4982364694327301 0.33097909135060205 0.6673581627823129 0.3580229034172041 0.29259736951736537 1.5377364223793544 0.1730158511649106 0.41819910726998466 1.7607960635912958e-07 6.7542909413557135 -1.167257378082128 IPQCSQLQEDVDPQK(ub)VAFLLHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPQCSQLQEDVDPQKVAFLLHK 22 1 Q8N0S6-2;Q8N0S6;Q8N0S6-3 Q8N0S6-2 CENPL Centromere protein L 1 57011700.0 24382000.0 24673000.0 7956700.0 True False 36989276.56296485 20269910.3789711 6384054.757454506 1.0 0.5479942367747238 0.17259204154986038 25.140603748689955 -7.915370466175395 0.34952377454467537 1.082025036842803 5.220244770984981e-12 0.998649900840771 0.012429292230550261 0.10579432087411192 0.06608113378574597 0.04514472108806487 0.08389790912745584 1.2151489999916216e-08 7.915370466175395 -1.0820250368375828 down IPQCSQLQEDVDPQK(ub)VAFLLHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPQCSQLQEDVDPQKVAFLLHK 22 1 Q8N0S6-2;Q8N0S6;Q8N0S6-3 Q8N0S6-2 CENPL Centromere protein L 1 23369000.0 2482600.0 12381000.0 8505400.0 True False 3400484.3097423757 11833966.481508082 6496599.694211555 1.0 3.4800826598740096 1.9104924776740828 21.697308804364997 -10.05603178600153 6.273179605377874 0.9999979698048024 2.6952875687740705 0.608677782770956 0.640782508612071 1.819435241196505e-05 2.738264752243415e-06 0.6204357444155209 0.20681166536628387 8.789581835506622e-11 10.05603178600153 1.6952895989692682 IPQCSQLQEDVDPQK(ub)VAFLLHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPQCSQLQEDVDPQKVAFLLHK 22 1 Q8N0S6-2;Q8N0S6;Q8N0S6-3 Q8N0S6-2 CENPL Centromere protein L 1 51810000.0 24382000.0 19518000.0 7910000.0 True False 31562979.641072888 18431806.14229909 6470461.163453862 1.0 0.5839691420740832 0.20500159481248262 24.911730070782404 -7.740872281205655 0.3398100429392853 1.0767196804636339 1.5085292831129566e-20 0.9990830718437973 0.00983140250292672 0.12009348536899825 0.05260623989181363 0.03396976006029227 0.07853538374165352 1.8160496542925608e-08 7.740872281205655 -1.0767196804636339 down IPQIGDK(ub)FASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPQIGDKFASR 11 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 9389200.0 1617600.0 3512500.0 4259100.0 True False 1345106.0718304527 3493577.4653233364 5149658.118146594 1.0 2.5972505354683237 3.8284401698810377 20.35928851405392 -7.650451271155931 0.19765931863043595 9.151033024943202e-17 5.616635260012629 0.9999228414935859 0.010171200957420414 0.13738054795396634 0.023972228911339984 0.21175669007923206 0.3765583030915256 2.23639611345555e-08 7.650451271155931 5.616635260012629 IPRPQHK(ub)VR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPRPQHKVR 9 2 Q9H1C4 Q9H1C4 UNC93B1 Protein unc-93 homolog B1 1 2818699.0 265880.0 1342219.0 1210600.0 True False 221091.0004811334 1334988.1998373882 1463730.8628180274 1.0 6.038184263186724 6.620490475110648 17.754280775821236 -9.709311603919263 0.5742707020045914 8.894444436104891e-23 6.5705853041571505 0.9990820482805208 0.07645617398889033 0.9943781980274766 0.26263704175796215 2.1301090134159804 0.10422431086303788 1.9529377308128542e-10 9.709311603919263 6.5705853041571505 IPSAVGYQPTLATDMGTMQER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPSAVGYQPTLATDMGTMQER 21 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 25631800.0 3927800.0 10849000.0 10855000.0 False True 5149383.836869308 9230371.489070782 9731828.72851254 1.0 1.7925196065171576 1.8899015953779124 22.29596838245986 -11.12118224999732 0.37557540504474385 2.2194289810563424e-22 1.9012742389193595 0.9994868084956688 0.00902837877193121 3.0549358567489606 0.18698832306568677 2.6193729605395903 0.026690506114510185 7.565153596586746e-12 11.12118224999732 1.9012742389193595 IPSAVGYQPTLATDMGTMQER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPSAVGYQPTLATDMGTMQER 21 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 23954000.0 8169600.0 3238400.0 12546000.0 False True 7910260.519812945 4531510.008032905 9259826.2280677 1.0 0.5728648249552294 1.1706095146771054 22.915293779123747 -6.714824880835079 1.7776563241133412 0.7387202227802028 1.169437833868554 0.48817182147827287 0.17986224901508618 0.36544355109178095 2.2538942575334793 0.08042382115786664 0.20315455872268676 1.9283022995734107e-07 6.714824880835079 0.43071761108835127 IPSAVGYQPTLATDMGTMQER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPSAVGYQPTLATDMGTMQER 21 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 27974800.0 3927800.0 13334000.0 10713000.0 False True 5380013.804803872 12744859.790358512 8182810.041160714 1.0 2.3689269679900247 1.5209645064208193 22.359178443982753 -10.046884861198134 4.878193708348121 0.9999811904499926 1.9449457372174603 0.6234609437698432 0.34617922535578693 45729678.97387003 94182571.88798775 6501.573584859414 0.11850636194469363 8.976667495722289e-11 10.046884861198134 0.9449645467674678 IPTHLFTFIQFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPTHLFTFIQFK 12 0 P10155-3;P10155-5;P10155-4;P10155;H0Y9N5;P10155-2 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 0 46393800.0 11469000.0 25022000.0 9902800.0 False True 15035970.065953976 21288815.134992063 8878153.250365159 1.0 1.4158591059712493 0.5904609553904345 23.841914612548763 -6.769744100804044 1.5756363532068143 1.2386035915000035 0.5858848732789912 0.72952106851077 0.17525032451509062 0.26683654834939585 1.307374614767465 0.08767638002510807 0.20873793112527433 1.6992446028811996e-07 6.769744100804044 -0.6527187182210124 IPTHLFTFIQFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPTHLFTFIQFK 12 0 P10155-3;P10155-5;P10155-4;P10155;H0Y9N5;P10155-2 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 0 95082000.0 41234000.0 24922000.0 28926000.0 False True 39925049.24035048 34873484.566513106 21349412.838600837 1.0 0.8734738022882141 0.5347372951270886 25.250790851153383 -6.953978322806773 0.513318090852009 1.0060679474398178 0.3871980495396053 0.9994776165794399 0.004489271520144885 0.08192657230572734 0.029647781345645635 0.005141632761322854 0.027963383457618424 1.1117872191791925e-07 6.953978322806773 -0.6188698979002125 IPTHLFTFIQFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPTHLFTFIQFK 12 0 P10155-3;P10155-5;P10155-4;P10155;H0Y9N5;P10155-2 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 0 540930000.0 279850000.0 104650000.0 156430000.0 False True 424552909.77547795 85974389.86581802 125511541.9342954 1.0 0.20250571338984585 0.29563227349135673 28.66136911950626 -10.616810013731424 6.563596591165699 1.002293483126266 0.2490689936517981 0.9885967797319262 0.03801875895822201 0.0012783170724900638 7.462941092623902e-05 0.036879493493946605 0.012270501690722328 2.4165177320124813e-11 10.616810013731424 -0.7532244894744679 IPTHLFTFIQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPTHLFTFIQFK 12 0 P10155-3;P10155-5;P10155-4;P10155;H0Y9N5;P10155-2 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 0 112479000.0 11469000.0 30636000.0 70374000.0 False True 15709399.238071065 29282400.220295753 53753110.59802517 1.0 1.864005095072706 3.4217165012750317 23.905124674071654 -6.962022031898274 0.40593244811811413 0.9197771633001205 4.423371587521794 0.9998379965775808 0.012754671747000375 0.07898656742727869 0.018519517476719982 0.020042480240288714 0.1302337622201957 1.0913849687350643e-07 6.962022031898274 3.503594424221674 IPTHLFTFIQFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPTHLFTFIQFK 12 0 P10155-3;P10155-5;P10155-4;P10155;H0Y9N5;P10155-2 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 0 96567000.0 41234000.0 22092000.0 33241000.0 False True 34287897.97592541 21972986.01108135 40191539.41098137 1.0 0.6408379430698627 1.172178575636252 25.03119612658766 -6.724607377545007 1.7426894563590178 0.7825818138545967 1.1715792658320956 0.5342897072719548 0.15105638059270873 0.3463890284112408 2.0582381295664245 0.06876086284818575 0.1716902094540526 1.8853527660529086e-07 6.724607377545007 0.3889974519774989 IPTHLFTFIQFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPTHLFTFIQFK 12 0 P10155-3;P10155-5;P10155-4;P10155;H0Y9N5;P10155-2 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 0 515782000.0 279850000.0 159490000.0 76442000.0 False True 362271341.6682077 150614241.29702237 62530340.36115554 1.0 0.4157498095307935 0.17260636757302486 28.43249544159871 -9.966625509252298 0.2218139936902948 1.5892189095016331 1.371408586945807e-20 0.9992725630387399 0.009364846610442215 1.451717748766863 0.1004116446136165 0.650501092644662 0.1251783853237783 1.079877495793803e-10 9.966625509252298 -1.5892189095016331 IPTPLNTSGVQVICMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPTPLNTSGVQVICMK 16 0 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2;H7C4C3 E9PFW3 AP2M1 AP-2 complex subunit mu 0 4749690.0 886090.0 1731500.0 2132100.0 False True 1161672.570907765 1473166.9493341367 1911490.7445473575 1.0 1.2681430088195684 1.6454643007139804 20.14777205726289 -6.966297156288387 0.3350432403602947 0.9566513358589143 1.9694018963463662 0.9999374414543357 0.002094109420362008 0.0775234820435299 0.013322714900514957 0.0054111236730776165 0.032780436463571594 1.080694257386071e-07 6.966297156288387 1.012750560487452 IPTPLNTSGVQVICMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPTPLNTSGVQVICMK 16 0 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2;H7C4C3 E9PFW3 AP2M1 AP-2 complex subunit mu 0 4818690.0 886090.0 2498900.0 1433700.0 False True 1213701.418681872 2388490.335242753 1095089.5879783554 1.0 1.9679389827497675 0.9022726439322005 20.210982118785783 -6.667605309197569 1.9460289355277374 1.6190988679296412 0.9066357369293156 0.268452261821047 0.41138741736657547 0.4666133716617955 3.404470726257524 0.17033477733311156 0.4564899091663586 2.1497833293872577e-07 6.667605309197569 -0.7124631310003255 IPTRPFEEGK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPTRPFEEGKK 11 2 Q9H8Y8-3;Q9H8Y8;Q9H8Y8-2 Q9H8Y8-3 GORASP2 Golgi reassembly-stacking protein 2 1 5976600.0 1856600.0 2467300.0 1652700.0 True False 2434020.5793399774 2099188.4574600714 1481694.4578178395 1.0 0.8624366101412746 0.6087436032359365 21.214909935233752 -6.961599809818968 0.4122720930415808 1.0121916905479698 0.44953885978755875 0.9998249978347046 0.0021438323978802045 0.07913456430908658 0.01905605730410683 0.003269101922315317 0.021166141653412695 1.0924465316177735e-07 6.961599809818968 -0.5626528307604111 IPTRPFEEGK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPTRPFEEGKK 11 2 Q9H8Y8-3;Q9H8Y8;Q9H8Y8-2 Q9H8Y8-3 GORASP2 Golgi reassembly-stacking protein 2 1 10576000.0 2092500.0 3256700.0 5226800.0 True False 2026074.7328765916 4557117.293466146 3857744.2793610906 1.0 2.2492345516771817 1.90404836345001 20.950255959041698 -10.146675286296208 4.833452713003283 0.9999191711415564 2.076641457568963 0.9284232623215986 0.14092167125398014 0.0001227540075361273 2.1671595741647677e-05 0.1364569517491745 0.04548227382123285 7.133862160474114e-11 10.146675286296208 1.0767222864274069 IPTRPFEEGK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPTRPFEEGKK 11 2 Q9H8Y8-3;Q9H8Y8;Q9H8Y8-2 Q9H8Y8-3 GORASP2 Golgi reassembly-stacking protein 2 1 6098700.0 1856600.0 1890700.0 2351400.0 True False 2543035.1927284673 1807162.622291201 1796047.7486031265 1.0 0.7106321719253379 0.706261460218376 21.278119996756644 IPTRPFEEGK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPTRPFEEGKK 11 2 Q9H8Y8-3;Q9H8Y8;Q9H8Y8-2 Q9H8Y8-3 GORASP2 Golgi reassembly-stacking protein 2 1 29884700.0 3121400.0 6600300.0 20163000.0 True False 4040713.831992648 6232987.502870006 16493540.889850857 1.0 1.5425461346754799 4.081838401735366 21.946178751139016 -6.941289171719198 0.6474583297395315 0.9720104533522266 4.793382122464432 0.998327937742193 0.054928681387103225 0.08718338229106748 0.05196795224197404 0.05400647308851494 0.21734045183208586 1.144750464129411e-07 6.941289171719198 3.8213716691122053 IPVDTYNNILTVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPVDTYNNILTVLK 14 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 6059500.0 0.0 4047500.0 2012000.0 False True 0.0 3443628.777031426 1803817.5404668106 0.0 IPVDTYNNILTVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPVDTYNNILTVLK 14 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 4888600.0 0.0 2216700.0 2671900.0 False True 0.0 2118758.8643533625 2040852.2495078235 0.0 IPVGPETLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPVGPETLGR 10 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 18942900.0 6501500.0 2221400.0 10220000.0 False True 6295113.44124117 3108416.604447963 7543075.406571975 1.0 0.4937824605484941 1.1982429668630008 22.585800945622942 -6.713835138453018 1.7813157475446604 0.6900192319914513 1.1967981465620108 0.48338702427515 0.21319397589697978 0.36742305862710123 2.274887318678134 0.09515522854326908 0.24064119977863407 1.932701846362341e-07 6.713835138453018 0.5067789145705595 IPVQALLHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPVQALLHLR 10 0 A0A140T8Y2;P36915-2;P36915 A0A140T8Y2 GNL1 Guanine nucleotide-binding protein-like 1 0 18240100.0 6068800.0 6258600.0 5912700.0 False True 7956255.570342798 5324841.275831719 5300910.522623308 1.0 0.6692647349942149 0.6662569440809097 22.923658188399834 IPVQALLHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPVQALLHLR 10 0 A0A140T8Y2;P36915-2;P36915 A0A140T8Y2 GNL1 Guanine nucleotide-binding protein-like 1 0 13812900.0 6696500.0 2592100.0 4524300.0 False True 6483923.272978771 3627139.047622927 3339250.1039093463 1.0 0.5594049921501597 0.5150045679635665 22.628435588256746 -13.999999999999998 0.32436074371347684 5.636556942780981 0.5066124423299216 0.9997030191201067 0.0037725953903162894 18.3579167430169 0.18183066353364374 57.89580176056312 0.014534856135237407 1.0000000000000041e-14 13.999999999999998 -5.129944500451059 IPVQALLHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IPVQALLHLR 10 0 A0A140T8Y2;P36915-2;P36915 A0A140T8Y2 GNL1 Guanine nucleotide-binding protein-like 1 0 20365400.0 5453600.0 6864100.0 8047700.0 False True 8273509.911565286 5639147.72554191 6457068.567567779 1.0 0.6815907378873286 0.7804509375811154 22.98006807015378 -10.494045653931016 8.896095973302456 1.0000084859450638 0.7310208377342221 0.9080067344977409 0.04035950751990457 6.792975409518641e-06 3.863480648120872e-07 0.039079156710190764 0.013025975040476959 3.205932292581029e-11 10.494045653931016 -0.26898764821084165 IPVQALLHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPVQALLHLR 10 0 A0A140T8Y2;P36915-2;P36915 A0A140T8Y2 GNL1 Guanine nucleotide-binding protein-like 1 0 18539100.0 6068800.0 5643100.0 6827200.0 False True 8312599.363153348 5393769.18276377 5214755.97059763 1.0 0.6488667319481722 0.6273315653479823 22.986868249922725 -13.999999999999925 0.39709338600920374 6.809550656822667 0.6259802658332039 0.9998336169222506 0.002203496408881334 26.346295139134824 0.20735032496288777 131.73403480728848 0.005555134698496361 1.0000000000001718e-14 13.999999999999925 -6.1835703909894635 IPVQALLHLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPVQALLHLR 10 0 A0A140T8Y2;P36915-2;P36915 A0A140T8Y2 GNL1 Guanine nucleotide-binding protein-like 1 0 13546400.0 6696500.0 3363200.0 3486700.0 False True 5568436.455250138 3345081.7740570717 4215752.849320685 1.0 0.6007219083739742 0.7570801755932599 22.408840863691022 -10.07251018391899 5.044461998444904 1.0000067290191632 0.6789010419822922 0.8490130128861968 0.06383299529676649 4.830859497566651e-06 8.882539968746209e-07 0.06180732737952689 0.020602010642916835 8.462327249756752e-11 10.07251018391899 -0.32110568703687103 IPVQALLHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPVQALLHLR 10 0 A0A140T8Y2;P36915-2;P36915 A0A140T8Y2 GNL1 Guanine nucleotide-binding protein-like 1 0 24431800.0 5453600.0 11079000.0 7899200.0 False True 7059792.706527555 10462443.910776291 6461626.652636502 1.0 1.4819760785755947 0.9152714422708215 22.75119439224623 -6.681441562378708 1.8971249056912176 1.3045666893090033 0.9174237337203007 0.3305482073176421 0.2042105246389016 0.4353440492493345 3.0306605821906665 0.08634096978438406 0.22726886008524333 2.0823725854178646e-07 6.681441562378708 -0.3871429555887026 IPVTIITGYLGAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IPVTIITGYLGAGK 14 0 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;A0A087X140;F2Z2T4;A0A087WTC0;A0A087WZQ3 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 0 3782850.0 877150.0 1407700.0 1498000.0 False True 1149952.144332683 1197676.6471716228 1343001.3298306554 1.0 1.041501294705298 1.1678758428769216 20.133142393476014 -6.951115402930015 0.5464671186445142 0.9982145485929533 1.217063556927599 0.9992858893296097 0.0019078684310077244 0.08304104067560183 0.03413333218242133 0.002080284385997259 0.010477028627736893 1.1191404602794507e-07 6.951115402930015 0.2188490083346456 IPVTIITGYLGAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPVTIITGYLGAGK 14 0 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;A0A087X140;F2Z2T4;A0A087WTC0;A0A087WZQ3 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 0 4662100.0 1331600.0 1244100.0 2086400.0 False True 1289329.086880989 1740875.617895791 1539909.2493416595 1.0 1.3502182147361126 1.194349266614971 20.298189111856892 -10.38879795822315 5.6768507657890295 0.9999076750822498 1.2722837406755427 0.8027134058558943 0.06363323160685964 7.438042568196295e-05 8.008229154198321e-06 0.06163341224829275 0.020537537189893464 4.085093882103241e-11 10.38879795822315 0.27237606559329297 IPVTIITGYLGAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IPVTIITGYLGAGK 14 0 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;A0A087X140;F2Z2T4;A0A087WTC0;A0A087WZQ3 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 0 4382550.0 877150.0 1150300.0 2355100.0 False True 1201456.0590874574 1099475.9424665805 1798873.8848070183 1.0 0.915119561926939 1.497244839876473 20.196352454998905 -6.869869498042336 1.1348575511141952 0.9520373757954681 1.5312420100518571 0.964549095501503 0.048343650695016574 0.13697627738826176 0.3298079512527154 0.03306409002341156 0.07825881487705795 1.3493682958690945e-07 6.869869498042336 0.579204634256389 IPVTIITGYLGAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPVTIITGYLGAGK 14 0 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;A0A087X140;F2Z2T4;A0A087WTC0;A0A087WZQ3 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 0 1798800.0 1331600.0 467200.0 0.0 False True 1107284.399882191 464683.1008680611 0.0 1.0 0.4196601170552939 0.0 20.07859438729117 -8.204134855327805 0.5472404531940095 1.0268659668337539 1.0949495220667275e-19 0.9912507447111474 0.03835046967159128 0.1294870574901316 0.1732138014684386 0.054059207320828334 0.07294133453121804 6.24978596871131e-09 8.204134855327805 -1.0268659668337539 IPYEK(ub)QQLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IPYEKQQLPK 10 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3 D6REX3 SEC31A Protein transport protein Sec31A 1 6803400.0 2369900.0 2377800.0 2055700.0 True False 2294668.8217176753 3327267.940063193 1517250.500321917 1.0 1.4499991931613754 0.661206744067834 21.129854520896856 -6.751962396797147 1.642586596838648 1.2639762569905408 0.6594008714929616 0.6573874347072988 0.18911357097522247 0.29662602818677264 1.5752196463656565 0.09092672627045612 0.22029223189179525 1.7702622290834556e-07 6.751962396797147 -0.6045753854975793 IPYEK(ub)QQLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IPYEKQQLPK 10 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3 D6REX3 SEC31A Protein transport protein Sec31A 1 7379700.0 2369900.0 3878700.0 1131100.0 True False 1970676.854371287 3857804.673238327 1367607.7803844977 1.0 1.9576038885731462 0.6939787095742854 20.910259796331133 -6.704032801536395 1.8163028287973104 1.5922581935592233 0.6974146851170374 0.43683491824140186 0.40392494189222367 0.3871841772963548 2.4859120161031183 0.17722518679539878 0.4535525041438794 1.976820328537689e-07 6.704032801536395 -0.8948435084421859 IPYEK(ub)QQLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IPYEKQQLPK 10 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3 D6REX3 SEC31A Protein transport protein Sec31A 1 8452200.0 3000500.0 2801900.0 2649800.0 True False 3884206.3986973576 2645971.801931949 2167563.589244001 1.0 0.6812129764317688 0.5580454195150224 21.88918843394985 -13.999999999992307 0.13163684719028615 2.515437057609791 0.38909045085081695 0.9996382694831059 0.0035418570624160197 11.934538100404028 0.11298630211730654 4.672847628895903 0.15035412425740532 1.0000000000177147e-14 13.999999999992307 -2.126346606758974 IQAEFEK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQAEFEKK 8 1 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 1 4320900.0 1402100.0 2918800.0 0.0 True False 2127088.207240298 2397917.3353115097 0.0 1.0 1.127323882079431 0.0 21.020448430318833 -6.946565026489352 1.2100167447303964 1.070865828819584 1.5001792707385805e-22 0.9706965119165822 0.08629351915210522 0.10911657385981663 0.31782947367637154 0.05922071697496912 0.11287179981491731 1.1309280439026652e-07 6.946565026489352 -1.070865828819584 down IQAGEIGEMK(ub)DGVPEGAQLQGPVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQAGEIGEMKDGVPEGAQLQGPVHR 25 1 P16989;P16989-3 P16989 YBX3 Y-box-binding protein 3 1 16889300.0 5010300.0 7337600.0 4541400.0 True False 6568551.819814214 6242858.681740776 4071499.4921848783 1.0 0.9504162946403231 0.6198473581198051 22.64714390141374 -6.933647758100966 0.7162172267177235 1.0044107335887358 0.5452168778143531 0.997207838294131 0.008916228934919578 0.09078760684636526 0.06872239499569116 0.008307145282992168 0.029334025039097735 1.1650705965555575e-07 6.933647758100966 -0.45919385577438265 IQAGEIGEMK(ub)DGVPEGAQLQGPVHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQAGEIGEMKDGVPEGAQLQGPVHR 25 1 P16989;P16989-3 P16989 YBX3 Y-box-binding protein 3 1 22170000.0 9671900.0 6959500.0 5538600.0 True False 9364870.828630397 9738464.643313056 4087874.5055615967 1.0 1.0398931092077108 0.4365115739839248 23.158827664574176 -6.891093830710908 1.015866069942663 1.03157528282688 0.38348456656015467 0.9815900288486499 0.03738288787949939 0.11826106318723596 0.21668820285634996 0.02799741900428877 0.07008015736818947 1.285008999648477e-07 6.891093830710908 -0.6480907162667253 down IQAGEIGEMK(ub)DGVPEGAQLQGPVHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQAGEIGEMKDGVPEGAQLQGPVHR 25 1 P16989;P16989-3 P16989 YBX3 Y-box-binding protein 3 1 37832000.0 12016000.0 17634000.0 8182000.0 True False 18229150.487268668 14487074.924929142 6564824.113701999 1.0 0.7947202440973313 0.3601278138708058 24.119743994850154 -6.958917533102037 0.4504366436159337 1.0139523277227438 0.12365479314628745 0.9997279013262694 0.00440030829295845 0.08009018245116833 0.022577970569434284 0.005812554061314838 0.03594560549097083 1.0992145462239423e-07 6.958917533102037 -0.8902975345764563 down IQAGEIGEMK(ub)DGVPEGAQLQGPVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQAGEIGEMKDGVPEGAQLQGPVHR 25 1 P16989;P16989-3 P16989 YBX3 Y-box-binding protein 3 1 16783500.0 5010300.0 7420700.0 4352500.0 True False 6862743.308266412 7092828.937026656 3324529.1425512894 1.0 1.0335267717915515 0.4844315156807306 22.710353962936633 -6.892372447687856 1.008222080581894 1.027847437036519 0.4349454717297876 0.9823745505591759 0.03336501680375603 0.11724013895447521 0.21076283247424543 0.025132886491915685 0.06321753063811995 1.2812313369933252e-07 6.892372447687856 -0.5929019653067313 down IQAGEIGEMK(ub)DGVPEGAQLQGPVHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQAGEIGEMKDGVPEGAQLQGPVHR 25 1 P16989;P16989-3 P16989 YBX3 Y-box-binding protein 3 1 44265700.0 12016000.0 24615000.0 7634700.0 True False 15554948.870770691 23245153.611676026 6245262.93863733 1.0 1.494389586542197 0.40149684775710226 23.890870316942603 -6.783731040166671 1.5213624967001802 1.2785853855061553 0.3918113522877669 0.7803382938416731 0.20942811791327703 0.24483312888783698 1.119487545283307 0.1083977782908915 0.254984278135629 1.645390402799515e-07 6.783731040166671 -0.8867740332183884 down IQAIAWAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQAIAWAR 8 0 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 26841000.0 8400800.0 8664300.0 9775900.0 False True 11013530.15346292 7371620.213176884 8764383.645054419 1.0 0.6693240142316284 0.7957833249585905 23.39277363253173 -10.037875561210276 5.638509153711795 1.0000010052841044 0.7325536700016609 0.8563966524846023 0.051626797417873606 6.524242234031228e-07 1.112986313391563e-07 0.049987619725875454 0.016662477218069398 9.164830532200806e-11 10.037875561210276 -0.26744733528244347 IQAIAWAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQAIAWAR 8 0 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 13340600.0 6282300.0 1766600.0 5291700.0 False True 6082871.825257167 2472012.5926972954 3905645.0224028314 1.0 0.40638906485470544 0.6420725497101382 22.536321174222227 -10.264223620087952 5.608913345486691 1.0000355214234016 0.5242308072824208 0.8445616159027025 0.09621737978283491 4.274226375506575e-05 5.606779839688651e-06 0.0931690127316737 0.031054025792880517 5.442223582640821e-11 10.264223620087952 -0.4758047141409808 IQAIAWAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQAIAWAR 8 0 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 20546900.0 6124000.0 9408200.0 5014700.0 False True 9290555.724370293 7729233.203397885 4023542.346978913 1.0 0.8319451960363509 0.43307875937115975 23.147333464835672 -6.956565329482511 0.4814065838055083 1.0094483269078611 0.23890629847345876 0.9996208336949785 0.004629560285393113 0.08095167996329533 0.025844180684063935 0.005640046740516869 0.03290157736974468 1.1051842076730244e-07 6.956565329482511 -0.7705420284344023 down IQAIAWAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQAIAWAR 8 0 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 14120300.0 6282300.0 4575400.0 3262600.0 False True 5224010.803078924 4550751.412054209 3944794.575442011 1.0 0.871122128876933 0.7551275684799561 22.316726449656503 -6.972375342885467 0.19320121591415296 1.0754007342328955 0.5476695314630317 0.9999954645639852 0.00021291901748548173 0.07553920810153458 0.006186961226675828 0.0039854189252838375 0.012534637574944963 1.0656747042335432e-07 6.972375342885467 -0.5277312027698638 IQAIAWAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQAIAWAR 8 0 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 28571900.0 6124000.0 15038000.0 7409900.0 False True 7927638.722087203 14201122.080535583 6061374.231994543 1.0 1.7913432458734304 0.7645875959391214 22.91845978692812 -6.700863534656232 1.8278589934180556 1.4909739592093165 0.7675974559806544 0.4216733853053892 0.3339826995760725 0.3937140764195224 2.557990262021877 0.14573813362177526 0.3743914216598353 1.9912989527536956e-07 6.700863534656232 -0.7233765032286621 IQALPTVPVTEEHVGSGLECPVCK(ub)DDYALGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQALPTVPVTEEHVGSGLECPVCKDDYALGER 32 1 Q9BV68;K7EIY6 Q9BV68 RNF126 E3 ubiquitin-protein ligase RNF126 1 44810800.0 21441000.0 13589000.0 9780800.0 True False 28109358.63493935 11561574.16950712 8768776.640058534 1.0 0.4113069358735323 0.3119522132802819 24.74454720064952 -13.999999999999998 0.2503318354898664 5.100942597963697 0.27212915491798567 0.9995433132639826 0.006489109801136778 14.011186995152906 0.1583218949283479 28.89913414650248 0.0457672822122901 1.0000000000000041e-14 13.999999999999998 -4.8288134430457115 IQALPTVPVTEEHVGSGLECPVCK(ub)DDYALGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQALPTVPVTEEHVGSGLECPVCKDDYALGER 32 1 Q9BV68;K7EIY6 Q9BV68 RNF126 E3 ubiquitin-protein ligase RNF126 1 217815000.0 75172000.0 103640000.0 39003000.0 True False 114041419.80933443 85144632.25698397 31294039.954377808 1.0 0.7466114715104132 0.2744094207762253 26.76498266507224 -6.998506182592863 0.4242896690616846 1.0203329518505262 3.846088111661119e-14 0.999816063223189 0.0040778821395505115 0.07484347046654453 0.019592283474471575 0.006043813792575913 0.037088322774434544 1.0034455640491308e-07 6.998506182592863 -1.0203329518504878 down IQALPTVPVTEEHVGSGLECPVCK(ub)DDYALGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQALPTVPVTEEHVGSGLECPVCKDDYALGER 32 1 Q9BV68;K7EIY6 Q9BV68 RNF126 E3 ubiquitin-protein ligase RNF126 1 67738000.0 21441000.0 17384000.0 28913000.0 True False 29368317.12123829 16615917.398799509 22084344.881926604 1.0 0.5657769674103448 0.7519785621613253 24.807757262172412 -10.227737086048233 5.502839336039458 1.000019198676382 0.6588777647858133 0.8173512404913448 0.07601648273880954 1.7905755995050573e-05 2.5127706595490365e-06 0.07360678112698332 0.024534214307044954 5.919198632122039e-11 10.227737086048233 -0.3411414338905687 IQALPTVPVTEEHVGSGLECPVCK(ub)DDYALGER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQALPTVPVTEEHVGSGLECPVCKDDYALGER 32 1 Q9BV68;K7EIY6 Q9BV68 RNF126 E3 ubiquitin-protein ligase RNF126 1 196185000.0 75172000.0 96390000.0 24623000.0 True False 97311635.86164916 91025811.76638013 20141866.65331538 1.0 0.9354052160400862 0.20698312668334617 26.53610898716469 -6.92431022031203 0.792100407618747 1.0137156230667421 0.0770249918014963 0.9952969151891439 0.024659301095488247 0.0957016540947128 0.09295466837415613 0.0217468497845287 0.06808755735608626 1.190391397373157e-07 6.92431022031203 -0.9366906312652459 down IQALQTACPDLQLSAASVGNCPTK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQALQTACPDLQLSAASVGNCPTKK 25 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 148420000.0 70126000.0 42069000.0 36225000.0 True False 106386268.8973206 34561458.26340275 29065112.872018486 1.0 0.32486766028762576 0.2732036114554489 26.66473671565139 -13.98928976196925 0.36443088171293503 9.999999999951434 0.2673340719954146 0.999780915552351 0.004900925129411052 21.990163768824893 0.19531366767726677 154.1821723615978 0.01470320967971969 1.0249678378922897e-14 13.98928976196925 -9.73266592795602 IQAQLALKPGLIGNANMVGLANLHAMGIAPPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQAQLALKPGLIGNANMVGLANLHAMGIAPPK 32 1 O43395;O43395-3 O43395 PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 0 66683000.0 15527000.0 23431000.0 27725000.0 False True 23555594.175750725 19249554.982761424 22245141.597700816 1.0 0.817196749066846 0.94436767044497 24.489566387794426 -10.007158941304183 4.813577890419249 1.0000019825460893 0.8807822097723282 0.5395477181650372 0.05191731125994201 1.1045997577318257e-06 2.2790494777398313e-07 0.05026955603458472 0.016756240155960132 9.836510473234321e-11 10.007158941304183 -0.11921977277376106 IQAQLALKPGLIGNANMVGLANLHAMGIAPPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQAQLALKPGLIGNANMVGLANLHAMGIAPPK 32 1 O43395;O43395-3 O43395 PRPF3 U4/U6 small nuclear ribonucleoprotein Prp3 0 44062000.0 15527000.0 14889000.0 13646000.0 False True 20100007.582927484 14060414.061517136 11162568.019783989 1.0 0.6995228237356363 0.5553514332634001 24.260692709886875 -13.999999999999982 0.09716239116896493 2.497110632463453 0.23431240262283712 0.9998078440498793 0.0025676282845800277 12.102657128721413 0.09224270387343048 3.6605641370456854 0.2868284677900735 1.0000000000000409e-14 13.999999999999982 -2.262798229840616 IQASGILQLFASLLTPQSSCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQASGILQLFASLLTPQSSCK 21 0 P52306-6;P52306-2;P52306-3;P52306-4;P52306;P52306-5;D6RBC6;D6REZ0;D6RB97 P52306-6 RAP1GDS1 Rap1 GTPase-GDP dissociation stimulator 1 0 2343480000.0 1057800000.0 699830000.0 585850000.0 False True 1604759935.5386815 574939868.703253 470056490.7128235 1.0 0.35827157443973623 0.2929138996450807 30.579710347151945 -13.999999999999998 0.322824934084556 7.691506114671372 0.2803435648128403 0.9996997610041514 0.005528069378003963 18.23526554780064 0.1813282660605985 82.53716040224987 0.021522419060391436 1.0000000000000041e-14 13.999999999999998 -7.411162549858532 IQASGILQLFASLLTPQSSCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQASGILQLFASLLTPQSSCK 21 0 P52306-6;P52306-2;P52306-3;P52306-4;P52306;P52306-5;D6RBC6;D6REZ0;D6RB97 P52306-6 RAP1GDS1 Rap1 GTPase-GDP dissociation stimulator 1 0 1674340000.0 1057800000.0 203610000.0 412930000.0 False True 1369342952.3552961 192278924.51242536 337780977.0195961 1.0 0.14041692344616952 0.24667376163042745 30.350836669244394 -10.63305877814382 6.592465770509828 1.0030727873594247 0.19354534637096704 0.9871472202119603 0.04337917253881874 0.0019623149012897583 0.00010922369563723313 0.042069959545427436 0.014000567734591976 2.3277761912095254e-11 10.63305877814382 -0.8095274409884576 IQASTK(ub)EDQALSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQASTKEDQALSK 13 1 H7BYE2;Q9NWZ8 H7BYE2 GEMIN8 Gem-associated protein 8 1 6467600.0 1995900.0 1719000.0 2752700.0 True False 2616644.2283230973 1462531.9006095177 2467877.009762914 1.0 0.5589341817197655 0.9431457983665122 21.31928635120889 -10.195677085400876 7.7903179445774136 1.0000001349579144 0.7510399900431389 0.35890490423354837 0.15685373567239144 3.6757447486566204e-07 3.8055479237248287e-08 0.15187305798254763 0.050624325504132706 6.372691788634902e-11 10.195677085400876 -0.24896014491477547 IQASTK(ub)EDQALSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQASTKEDQALSK 13 1 H7BYE2;Q9NWZ8 H7BYE2 GEMIN8 Gem-associated protein 8 1 7976400.0 1882800.0 1783900.0 4309700.0 True False 1823031.5445926154 2496220.5729156076 3180860.28177135 1.0 1.3692689960959654 1.7448191125415564 20.797908094405884 -6.9709153057565265 0.23530790608449859 0.8570548216342262 2.2678329467855485 0.9999886657603088 0.0010236927421413133 0.07600687603481612 0.007959977197557599 0.00928321631386748 0.03692578484506404 1.0692633820409249e-07 6.9709153057565265 1.4107781251513223 IQASTK(ub)EDQALSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQASTKEDQALSK 13 1 H7BYE2;Q9NWZ8 H7BYE2 GEMIN8 Gem-associated protein 8 1 5908000.0 1995900.0 1480700.0 2431400.0 True False 2733838.1671694224 1415277.7779798887 1857153.3962548429 1.0 0.5176889382026763 0.6793208971025938 21.382496412731783 -10.5333662976855 7.101684955460655 1.000194892302649 0.5985049176526351 0.8916231297644822 0.06598597090521671 0.0002037116517925957 1.3385368037769461e-05 0.06392100371330098 0.021296880533269297 2.9284222794914535e-11 10.5333662976855 -0.40168997465001377 IQASTK(ub)EDQALSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQASTKEDQALSK 13 1 H7BYE2;Q9NWZ8 H7BYE2 GEMIN8 Gem-associated protein 8 1 8846700.0 1882800.0 2958100.0 4005800.0 True False 1565631.62218248 2942164.1281631193 4843394.259273468 1.0 1.8792186402455018 3.0935720706265553 20.57831336984016 -6.9665924641648775 0.32957979745764754 0.8513263398885257 4.161192937495096 0.9999423077599428 0.006519551813767184 0.07742465302359154 0.012976601859752704 0.01774595634494453 0.10595454875263835 1.079959665854395e-07 6.9665924641648775 3.30986659760657 IQASTK(ub)EDQALSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQASTKEDQALSK 13 1 H7BYE2;Q9NWZ8 H7BYE2 GEMIN8 Gem-associated protein 8 1 18729200.0 3045300.0 4972900.0 10711000.0 True False 3942200.881837386 4696153.743469571 8761707.904140884 1.0 1.191251761194062 2.222542221150642 21.910569862663095 -6.9381359916206975 0.6766904785686296 0.987965913652379 2.486026519520303 0.9979093145862166 0.024551077922791334 0.088627527174638 0.05856166315221913 0.023573622509410464 0.0895146295153832 1.1530921309174194e-07 6.9381359916206975 1.498060605867924 up IQASTMAFK ddPTM_RPMI8226_Bortezomib_1h_R1 2 IQASTMAFK 9 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 47875900.0 6470500.0 29517300.0 11888100.0 False True 8482888.160411138 25113433.897534266 10658033.450707497 1.0 2.9604815509340745 1.2564156510335198 23.016124110681037 -6.612257944984689 2.1457677872676277 2.3078432195252057 1.2626650733300038 0.057336699405845626 0.8447509897943943 0.6064408041647301 5.294699144948676 0.324761091179712 0.9372991151292311 2.441979731768895e-07 6.612257944984689 -1.0451781461952019 IQASTMAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQASTMAFK 9 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 24775700.0 7884100.0 2622600.0 14269000.0 False True 7633823.561038149 3669817.856678322 10531520.839175692 1.0 0.48073129111976115 1.3795866193354194 22.863974411555283 -6.7500339951444746 1.6494911303488995 0.6946866597357068 1.3814060534950188 0.649246096647266 0.2182008330019869 0.29996703348522735 1.6057598127448542 0.10449363368305668 0.2536959127313082 1.7781402176199185e-07 6.7500339951444746 0.686719393759312 IQASTMAFK ddPTM_RPMI8226_Bortezomib_8h_R1 2 IQASTMAFK 9 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 139599000.0 5366100.0 126180000.0 8052900.0 False True 8140766.014458428 103662193.15116018 6461240.785288546 1.0 12.73371485767441 0.7936895341068695 22.956733122202035 -6.650198237876179 2.0078566292813846 8.613127769014195 0.8440952705378753 0.19470998583122645 5.007906945753437 0.508148408886705 3.9269402368809407 2.0226242446134126 5.546820650662684 2.237699486050202e-07 6.650198237876179 -7.76903249847632 IQASTMAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 IQASTMAFK 9 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 54542500.0 6470500.0 22027900.0 26044100.0 False True 8862818.708687678 21054634.54147582 19893019.97507642 1.0 2.375613812436133 2.2445477707421126 23.07933417220393 -10.227436390191128 4.572677974748818 0.9996157505994298 2.3100807915993617 0.9925492916832424 0.05350748749436334 18857891.732957095 52.15349305400821 76294.47446353383 0.01831703617983801 5.923298372958415e-11 10.227436390191128 1.310465040999932 IQASTMAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQASTMAFK 9 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 12946500.0 7884100.0 2931300.0 2131100.0 False True 6555978.47485069 2915508.505082505 2576703.1569069056 1.0 0.4447098959013749 0.3930310581084678 22.64437968698956 -13.999999999999998 0.3359243908763159 7.265193774354305 0.3845015754365033 0.9997270029164329 0.004539724201576882 19.336076505112867 0.18567121803028933 85.8500838910459 0.01620299926392126 1.0000000000000041e-14 13.999999999999998 -6.880692198917802 IQASTMAFK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IQASTMAFK 9 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 23714500.0 5366100.0 10295100.0 8053300.0 False True 6946522.231644697 9722168.634879785 6587682.033836031 1.0 1.399573529123783 0.9483424675193612 22.727859444294484 -6.673012181842135 1.926263918087082 1.2543903477435643 0.9501281484411682 0.292436916689638 0.16961508564677505 0.45436653893716966 3.25298674513333 0.07080848154037978 0.18847223500857782 2.123184906405622e-07 6.673012181842135 -0.30426219930239606 IQDALSTVLQYAEDVLSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQDALSTVLQYAEDVLSGK 19 0 O00303;H0YDT6 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 419648000.0 195920000.0 131680000.0 92048000.0 False True 297224963.6705793 108180675.1794642 73854672.45392838 1.0 0.36396900799814086 0.24848071824741838 28.146980050787224 -13.999999999999998 0.23994964876073235 5.208889872550011 0.19739346912191286 0.9995248782112074 0.007202469644307469 13.621634213944459 0.1550375681411987 27.470571133560412 0.05644863327537026 1.0000000000000041e-14 13.999999999999998 -5.011496403428098 IQDIVGILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQDIVGILR 9 0 P46087-2;P46087;P46087-4;P46087-3;F5GYR3;F5H5X6 P46087-2 NOP2 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase 0 3077100.0 635300.0 1158100.0 1283700.0 False True 832884.4522539512 985315.9942384443 1150875.0381199024 1.0 1.1830164335184585 1.381794359356097 19.667756835906385 -6.970068426646804 0.2565481153067348 0.9417876081777417 1.6288942210494037 0.9999829097398836 0.0006445166167848165 0.07628052735227776 0.008950743228638348 0.004243909613279794 0.018853796823105902 1.0713504919086763e-07 6.970068426646804 0.6871066128716621 IQDIVGILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQDIVGILR 9 0 P46087-2;P46087;P46087-4;P46087-3;F5GYR3;F5H5X6 P46087-2 NOP2 Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase 0 2767000.0 635300.0 1081000.0 1050700.0 False True 870187.5783369564 1033237.8456110357 802546.2998457542 1.0 1.1873737011802556 0.92226816358322 19.730966897429276 -6.716866308249538 1.7711170678369093 1.1143789842672995 0.9227668087857948 0.49747328727107554 0.07887937408365946 0.36143007962424056 2.2140897019820893 0.03539051562744437 0.0891549002939332 1.9192594681118144e-07 6.716866308249538 -0.19161217548150478 IQDK(ub)EGIPPDQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQDKEGIPPDQQR 13 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 122492470.0 43965800.0 31852900.0 46673770.0 True False 57639589.56541283 27100571.481631745 41844416.00681586 1.0 0.470172873990999 0.7259665851598116 25.78055672675314 -10.084201035785295 5.181504961278301 1.0000072265960473 0.5980697295746612 0.7670086401342573 0.10442734529867975 8.717915314782432e-06 1.5408969957502556e-06 0.101113160111158 0.033703780768828476 8.237567081131458e-11 10.084201035785295 -0.40193749702138615 IQDK(ub)EGIPPDQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQDKEGIPPDQQR 13 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 101006500.0 17101100.0 30487500.0 53417900.0 True False 16558234.941168893 42661317.74021222 39426149.48735038 1.0 2.576441141932525 2.381059915349116 23.98104555822394 -9.896953866830433 5.953858596362451 0.9999995996050818 2.478750528641683 0.9870762718086447 0.07976405174447558 4.2384706409563057e-07 7.866998772168992e-08 0.07723123171937378 0.0257437370022497 1.2677865300249115e-10 9.896953866830433 1.4787509290366012 IQDK(ub)EGIPPDQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQDKEGIPPDQQR 13 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 200064200.0 37069000.0 100973200.0 62022000.0 True False 56236383.1069043 82953743.55278753 49763324.51479166 1.0 1.4750903057740046 0.884895538537614 25.745000473388494 -6.692464635636558 1.8578947451040297 1.2971627039288145 0.8868850907962113 0.38191399921913405 0.20083037099247347 0.4113729981937816 2.7550015540485377 0.08641884986697264 0.22432447722881746 2.030183829894061e-07 6.692464635636558 -0.41027761313260325 IQDK(ub)EGIPPDQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQDKEGIPPDQQR 13 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 112336700.0 43965800.0 19571900.0 48799000.0 True False 60221144.39107031 18707148.742381707 37273681.24695249 1.0 0.3106408709356183 0.6189467441020515 25.84376678827603 -10.503502695814765 6.276793123414338 1.0004093645819583 0.46479380751927263 0.8007201606750822 0.125865345660165 0.0007215605948693553 5.7075755984791096e-05 0.12195751808814136 0.040622865633871554 3.136875658435123e-11 10.503502695814765 -0.5356155570626857 IQDK(ub)EGIPPDQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQDKEGIPPDQQR 13 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 86722500.0 17101100.0 34757200.0 34864200.0 True False 14220322.357183356 34569956.06483595 42154143.02615253 1.0 2.4310247824567095 2.9643591732544996 23.761450833658216 -9.708186968151178 0.2675854414739288 6.302674656604544e-17 3.2330234482346167 0.9989715534114819 0.026598029479605215 1.1081950764274138 0.11307769874095282 1.1194790769565148 0.21678780967963723 1.958001552632302e-10 9.708186968151178 3.2330234482346167 IQDK(ub)EGIPPDQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQDKEGIPPDQQR 13 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 198292120.0 37069000.0 97088600.0 64134520.0 True False 47986551.239230916 91685534.06226146 52462695.43574652 1.0 1.9106506238628145 1.0932791392780103 25.516126795480943 -10.19862984804292 4.2725448884495165 0.9998125116931691 1.5019648815964164 0.334601691214667 0.3336905113398147 234545699.34800044 152.4239885708405 436427.4379786601 0.11423113766649304 6.329510897965256e-11 10.19862984804292 0.5021523699032473 IQEAGTEVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQEAGTEVVK 10 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 25451500.0 1127500.0 14258000.0 10066000.0 False True 1478163.4187255304 12130761.977248697 9024466.879890114 1.0 8.206644694067599 6.1051888888381445 20.4953743451357 -9.29596234091677 8.496809536043893 0.9999744124519355 7.155916791462478 0.9196239640411301 0.8579157401219503 62546081.55676872 68428745.21589553 0.8306733434169228 0.29368737711798565 5.058685256020304e-10 9.29596234091677 6.1559423790105425 IQEAGTEVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQEAGTEVVK 10 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 29176500.0 7020300.0 2879200.0 19277000.0 False True 6797444.419217935 4028879.574829644 14227775.402396077 1.0 0.5927050412415403 2.0931065448907376 22.696561019112792 -6.8343997372141025 1.3081984450885946 0.7829492057861968 2.13721711910534 0.9143877084738602 0.18536136558995567 0.17543702941438963 0.5856257382824253 0.11119929573938393 0.25591663522631974 1.4641995289029486e-07 6.8343997372141025 1.354267913319143 up IQEAGTEVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQEAGTEVVK 10 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 29664500.0 1127500.0 12533000.0 16004000.0 False True 1544367.2195418193 11979250.618911287 12224184.812726235 1.0 7.756737171917748 7.91533558731769 20.558584406658593 -10.013787783367786 0.8488967314506175 1.4997922018777913e-18 7.879157782249417 0.9999245691660181 0.0279936930823877 1.3159931551592756 0.458201498439549 3.614954630962599 0.02219594650581127 9.687511178088034e-11 10.013787783367786 7.879157782249417 IQEAGTEVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQEAGTEVVK 10 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 8484310.0 7020300.0 957590.0 506420.0 False True 5837690.502022336 952431.272603266 612310.0805784778 1.0 0.16315206711854932 0.10488909618732901 22.47696629454707 -13.617771059328108 0.38199824681550076 9.999999207796035 0.09986929607525255 0.9998017713973953 0.0057573178532057245 17.982667363625616 0.20118874154531013 131.62209501193755 0.01570343566748701 2.4111761582009913e-14 13.617771059328108 -9.900129911720782 IQEAGTEVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQEAGTEVVK 10 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 4928970.0 578170.0 2158400.0 2192400.0 False True 748452.4624345459 2038283.1426139153 1793405.6959236718 1.0 2.723330131059818 2.396151774409467 19.51355116161179 -10.305207809224452 5.940258528055423 0.9998836390554322 2.559740952734646 0.9680533916093698 0.13357000477929473 0.00020585180367424722 2.407656308690647e-05 0.1293379169581928 0.04310953367191927 4.9521317538038297e-11 10.305207809224452 1.5598573136792138 IQEAGTEVVK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQEAGTEVVKAK 12 1 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 1 9365750.0 1078100.0 1227100.0 7060550.0 True False 1043876.3056221029 1717087.4292419623 5211180.143040286 1.0 1.644914651280121 4.99214333630713 19.99351933885832 -6.938975827791156 0.6690227124862593 0.9616813086302949 5.868226307766129 0.9980266681144195 0.0777311829148613 0.0882369673706492 0.056760576910686006 0.07509080613209766 0.2894134713171261 1.1508644426284017e-07 6.938975827791156 4.906544999135834 IQEAGTEVVK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQEAGTEVVKAK 12 1 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 1 4170430.0 626500.0 593630.0 2950300.0 True False 858133.9805258994 567401.4637281024 2253499.9033357995 1.0 0.6612038173577227 2.6260466948934513 19.710843387837713 -6.862462728020097 1.1733246302653284 0.8148600047039412 2.7257244564833236 0.9565588243779679 0.17874727970738977 0.14428087689867064 0.37606039882532133 0.11870149218881733 0.27788056665011757 1.3725787532767056e-07 6.862462728020097 1.9108644517793825 up IQEAGTEVVK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQEAGTEVVKAK 12 1 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 1 7069700.0 1078100.0 1817900.0 4173700.0 True False 896487.917928048 1808106.6118751033 5046401.372991583 1.0 2.016877835960107 5.629079067406469 19.773924614292596 -6.947604025739076 0.5845563158898394 0.9575185888092039 6.868507524197216 0.9989995963173393 0.06282669807551051 0.08446234629914331 0.040055798960173084 0.0655059365815966 0.30213147902392035 1.1282256633922569e-07 6.947604025739076 5.910988935388012 IQEAK(ub)DVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQEAKDVYK 9 1 P43490;A0A0C4DFS8;C9JG65 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 2028060.0 686540.0 482190.0 859330.0 True False 900060.5884628163 410249.131561899 770414.7748754187 1.0 0.4558016835983785 0.8559587929421336 19.77966259558213 -9.897230623550422 5.9799678566461605 1.0000000875354944 0.6558802382700851 0.4964868246113101 0.16336345580718337 1.9075665956966515e-07 3.507939072442533e-08 0.15817602599861855 0.05272532864324987 1.266978882947723e-10 9.897230623550422 -0.3441198492654093 IQEAK(ub)DVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQEAKDVYK 9 1 P43490;A0A0C4DFS8;C9JG65 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 3048740.0 455860.0 762080.0 1830800.0 True False 441388.9738251477 1066382.5181946992 1351258.5571772945 1.0 2.415969997966322 3.0613781433348253 18.751691065072766 -9.360547492408868 0.2410005029715091 5.3778372043310826e-21 3.504008103493979 0.9991779109242499 0.024684663728589067 0.7740936678863434 0.09238699397715773 0.896917544069735 0.29253052133357815 4.3596588620772833e-10 9.360547492408868 3.504008103493979 IQEAK(ub)DVYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQEAKDVYK 9 1 P43490;A0A0C4DFS8;C9JG65 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 11983400.0 1095800.0 1910900.0 8976700.0 True False 1662408.7137108054 1569884.9650701536 7202451.310372616 1.0 0.9443435613170472 4.332539435681497 20.664843690754502 -6.903168064349531 0.9410385205746895 0.8711129767466357 4.71196295035638 0.988077180346049 0.17298749003552938 0.10911023485576767 0.16456657797774177 0.13700758797333623 0.3624774680118682 1.2497752954996643e-07 6.903168064349531 3.8408499736097443 up IQEAK(ub)DVYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQEAKDVYK 9 1 P43490;A0A0C4DFS8;C9JG65 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 3198860.0 455860.0 1072300.0 1670700.0 True False 379067.78802215 1066523.3070651155 2020035.645555989 1.0 2.8135424342698188 5.328956216764988 18.532096340507042 -6.966525931398181 0.3308189356043353 0.6964540710889252 7.528490952054052 0.9999412321634253 0.01360729632769871 0.07744689567713516 0.013054490670567728 0.03659754358354306 0.21925575032057024 1.080125125494312e-07 6.966525931398181 6.832036880965127 IQEAK(ub)DVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQEAKDVYK 9 1 P43490;A0A0C4DFS8;C9JG65 P43490 NAMPT Nicotinamide phosphoribosyltransferase 1 15566400.0 1095800.0 1573600.0 12897000.0 True False 1418534.701447283 1486027.7766944272 10549878.334395012 1.0 1.0475794319154008 7.437166199481288 20.43597001284695 -6.908532607923594 0.9056721514191379 0.7928676964695872 8.237503506186945 0.9903558700047375 0.2969073639954193 0.10539631610127181 0.14409095715548395 0.24133199628081514 0.6596010636856897 1.2344326273801872e-07 6.908532607923594 7.444635809717358 up IQEIIEQLDVTTSEYEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQEIIEQLDVTTSEYEK 17 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 38386500.0 17651000.0 3128500.0 17607000.0 False True 17090678.666668896 4377726.364911976 12995198.501322165 1.0 0.25614701734751116 0.7603676106008627 24.026706351430228 -9.886660530506234 6.100165230134004 1.0000000794663202 0.5082573139770357 0.5591136241371514 0.20584719521297748 2.2259706345027198e-07 4.08967251873232e-08 0.19931072239988248 0.0664368965768562 1.2981936171388343e-10 9.886660530506234 -0.49174276548928453 IQEIIEQLDVTTSEYEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQEIIEQLDVTTSEYEK 17 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 112340400.0 4543400.0 97012000.0 10785000.0 False True 6892669.967031999 79699450.64178433 8653340.022766577 1.0 11.562928592692087 1.2554409342324464 22.716631507558308 -6.640498002147797 2.042634899580433 7.905061679838932 1.2984306621838566 0.1564592489940806 4.519032430293443 0.5321750062279968 4.2443224624872995 1.8012282943435478 5.00413363837969 2.2882422379792648e-07 6.640498002147797 -6.606631017655075 IQEIIEQLDVTTSEYEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQEIIEQLDVTTSEYEK 17 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 3676950.0 1213300.0 766450.0 1697200.0 False True 1661889.798199639 732585.7046887875 1296356.3149312027 1.0 0.4408148515517776 0.7800495052894443 20.66439328785717 -10.415258486241655 6.0451577492951065 1.000113691601356 0.6104321784206248 0.6374639703357452 0.13849196745450337 0.00021226971550578064 2.053277947760558e-05 0.1341330653981687 0.04469809029456585 3.843629462897262e-11 10.415258486241655 -0.3896815131807312 IQEIIEQLDVTTSEYEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQEIIEQLDVTTSEYEK 17 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 21726800.0 17651000.0 1844800.0 2231000.0 False True 14677588.571883844 1834861.6962358726 2697491.785021495 1.0 0.12501111386585018 0.18378303573577254 23.807111626864504 -10.597985424339216 5.502619746286101 1.0051883961691506 0.15439707480944936 0.9963900805141714 0.023993536630673284 0.001529936409897772 0.00011177518556315883 0.023273121298900933 0.007743880648934347 2.5235654662045293e-11 10.597985424339216 -0.8507913213597011 IQEIIEQLDVTTSEYEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQEIIEQLDVTTSEYEK 17 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 13955600.0 4543400.0 5879700.0 3532500.0 False True 5881520.863803227 5552489.526328318 2889621.2465108414 1.0 0.9440567592814514 0.49130510856375614 22.487757829650757 -6.929882642507781 0.7477677551289841 1.006915486161458 0.3986387994695089 0.9965148203865548 0.013446085687024887 0.09269934622077326 0.07798289526843942 0.012241358590189573 0.04099289057698057 1.1752150852509869e-07 6.929882642507781 -0.6082766866919491 down IQEILTQVK(ub)QHQQQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQEILTQVKQHQQQK 15 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 11570550.0 3195750.0 3597900.0 4776900.0 True False 3094302.6655151104 5034560.2328006355 3525686.5860717865 1.0 1.6270419467717225 1.1394123223187875 21.561182888503367 -10.18876545155326 4.997105762355223 0.9999661443410355 1.383227134545776 0.45160831935881063 0.19907396056425317 139790547.66083053 4.226158291251358 54455.65185724261 0.06814831175781007 6.474922110036254e-11 10.18876545155326 0.3832609902047406 IQEILTQVK(ub)QHQQQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQEILTQVKQHQQQK 15 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 26760100.0 4468800.0 7152300.0 15139000.0 True False 6779496.313041467 5875916.183825044 12146770.014340587 1.0 0.8667186930276458 1.791692104172148 22.69274666072847 -6.870333608737006 1.1322523950392795 0.9244575053628775 1.8462256787343108 0.9650189392545063 0.0763585492099339 0.13653940572013845 0.32694072480858233 0.05232527345357508 0.12396165660459198 1.3479270577768104e-07 6.870333608737006 0.9217681733714332 IQEILTQVK(ub)QHQQQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQEILTQVKQHQQQK 15 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 12431650.0 3195750.0 7089100.0 2146800.0 True False 2657407.7207295834 7050909.611223829 2595685.954318305 1.0 2.653303652360889 0.9767736934269413 21.341588163937644 -6.649375536863798 2.0106835986027582 2.073370678244731 0.9838195985775832 0.19150466209990025 0.7057595001709875 0.5101010315566672 3.952151893910795 0.2847315167852314 0.781732737919267 2.2419424652036023e-07 6.649375536863798 -1.0895510796671481 IQELEDLLAK(ub)EK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQELEDLLAKEK 12 1 P20700;E9PBF6 P20700 LMNB1 Lamin-B1 1 55903000.0 27995000.0 16567000.0 11341000.0 True False 23279082.88878187 16477750.282707984 13712350.66514064 1.0 0.7078350277556925 0.5890417045487898 24.472530886638623 -13.9999999998133 0.12385154358746388 2.3894972626929736 0.4089188056138092 0.9996742711502491 0.0031164786155891537 11.95063951772294 0.10878595328817439 4.067766322074539 0.15991549844162845 1.0000000004298937e-14 13.9999999998133 -1.9805784570791642 IQEQFQK(ub)NPDSYNGAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQEQFQKNPDSYNGAVR 17 1 Q8IVD9 Q8IVD9 NUDCD3 NudC domain-containing protein 3 1 26403700.0 0.0 6887700.0 19516000.0 True False 0.0 5658536.121154278 15658654.045833344 0.0 IQEQFQK(ub)NPDSYNGAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQEQFQKNPDSYNGAVR 17 1 Q8IVD9 Q8IVD9 NUDCD3 NudC domain-containing protein 3 1 24452000.0 0.0 0.0 24452000.0 True False 0.0 0.0 20001986.898707196 0.0 IQESK(ub)NQCTQVVQER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQESKNQCTQVVQER 15 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 2619500.0 1351400.0 1268100.0 0.0 True False 1308500.5467189597 1774458.9430541405 0.0 1.0 1.3561010329751582 0.0 20.31948309649848 -6.868116214514036 1.365590466153462 1.187057920480993 8.880959936059923e-20 0.9180285126740826 0.16435480212171466 0.1584517317240985 0.5941166276005502 0.09727727472522485 0.20101104428651087 1.3548268205719736e-07 6.868116214514036 -1.187057920480993 down IQESK(ub)NQCTQVVQER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQESKNQCTQVVQER 15 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 10364300.0 2505200.0 2679000.0 5180100.0 True False 3243030.7848747303 2529911.294969737 4237374.952314459 1.0 0.780107085868277 1.306609537003867 21.62891128814574 -6.793234096855181 1.4831663004908682 0.8776200279532088 1.3127381099892514 0.8117244409284704 0.09368637768570566 0.2305466517297094 1.0017557683861906 0.04970864017847909 0.11612311966106255 1.6097776861424982e-07 6.793234096855181 0.43511808203604263 IQESPGK(ub)VAAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQESPGKVAAGR 12 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 2500350.0 483180.0 1095300.0 921870.0 True False 633453.6591217765 931885.5094459599 826483.7356014594 1.0 1.4711186777860452 1.304726436890902 19.272879555996123 -10.02053213202802 5.779661444720816 0.9999991532709073 1.3879225573385674 0.8787448649330242 0.06792934789222592 7.411888919545873e-07 1.2548574932017346e-07 0.06577245136015185 0.02192410275872825 9.538231699747198e-11 10.02053213202802 0.3879234040676601 IQESPGK(ub)VAAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQESPGKVAAGR 12 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 1791610.0 483180.0 832660.0 475770.0 True False 661824.7034485299 795870.3279615969 363402.92479072406 1.0 1.2025394697638265 0.5490924151020088 19.336089617519015 -6.823455061024236 1.3568908419293282 1.1088010955802503 0.5337450637271811 0.8921444634145976 0.08969514679215619 0.18902585030925373 0.6828920994445021 0.051933369871282414 0.11960024448712005 1.5015677736657794e-07 6.823455061024236 -0.5750560318530692 IQESYGDVYGICTK(ub)LK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQESYGDVYGICTKLK 16 1 P20020-1;P20020-4;P20020;P20020-2;P20020-6;P20020-5;F8W1V5 P20020-1 ATP2B1 Plasma membrane calcium-transporting ATPase 1 1 5508500.0 2121200.0 1861700.0 1525600.0 True False 2905464.963274596 1779443.9381813745 1165284.7007182653 1.0 0.6124472195238099 0.4010665127432597 21.470337626769233 -10.209287420067351 0.12707442296804933 1.792952884656099 2.5784084563216984e-13 0.9998300375238518 0.0032333500849731985 1.882780271682612 0.06248386028635432 0.710441107822532 0.23303137663506387 6.176075265352945e-11 10.209287420067351 -1.7929528846558411 IQEVGEPSK(ub)EEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQEVGEPSKEEK 12 1 Q99442;F8WF48;F8WCJ7 Q99442 SEC62 Translocation protein SEC62 1 57784000.0 0.0 37641000.0 20143000.0 True False 0.0 32025109.523468796 18058795.58529966 0.0 IQEVGEPSK(ub)EEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQEVGEPSKEEK 12 1 Q99442;F8WF48;F8WCJ7 Q99442 SEC62 Translocation protein SEC62 1 103911000.0 38269000.0 35937000.0 29705000.0 True False 37054171.54239151 50286831.508979276 21924369.3691018 1.0 1.357116605655292 0.5916842411122163 25.14313263386118 -6.7798385197753985 1.5365454431027417 1.2022487115054488 0.5856546377083501 0.7668166959839625 0.15100924329647253 0.2508174174809402 1.1696538614478744 0.07740806959215313 0.1826717147828056 1.6602040930253894e-07 6.7798385197753985 -0.6165940737970986 IQEVGEPSK(ub)EEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQEVGEPSKEEK 12 1 Q99442;F8WF48;F8WCJ7 Q99442 SEC62 Translocation protein SEC62 1 49678000.0 0.0 33483000.0 16195000.0 True False 0.0 32003610.3465257 12370074.546494702 0.0 IQEVGEPSKEEK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQEVGEPSKEEK 12 1 Q99442;F8WF48;F8WCJ7 Q99442 SEC62 Translocation protein SEC62 1 5967200.0 2023900.0 2791000.0 1152300.0 True False 2653352.499475478 2374593.67923279 1033071.0496421003 1.0 0.8949409020106474 0.38934557313674706 21.339384920527102 -6.940662034136277 0.6533809452020418 1.0056168499846792 0.25030813339912134 0.9982492628206647 0.011154003827892176 0.0874660503026075 0.05324512502235996 0.010912789503895638 0.043390254710441035 1.1464047210162686e-07 6.940662034136277 -0.7553087165855579 down IQEVGEPSKEEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQEVGEPSKEEK 12 1 Q99442;F8WF48;F8WCJ7 Q99442 SEC62 Translocation protein SEC62 1 5571100.0 2053500.0 2012400.0 1505200.0 True False 1988312.7665290686 2815961.814527361 1110942.9649679181 1.0 1.4162569701964405 0.5587365245897677 20.923113283583046 -6.77471494078175 1.5564623365586445 1.23731286199848 0.5530360080187553 0.748248573972671 0.17567759292635604 0.25887194893436977 1.238271038740032 0.08893487630457213 0.2107948592199326 1.679906301646303e-07 6.77471494078175 -0.6842768539797246 IQEVGEPSKEEK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQEVGEPSKEEK 12 1 Q99442;F8WF48;F8WCJ7 Q99442 SEC62 Translocation protein SEC62 1 11584300.0 5579200.0 3642100.0 2363000.0 True False 8464054.294155236 2992138.799142818 1895952.014260306 1.0 0.3535112955512358 0.2240004551447095 23.012917451225224 -13.999999999999998 0.2260257602798118 5.007456923327242 0.1586018488956842 0.9995046315976582 0.0075545807536376375 13.170610992159306 0.150562629072431 23.634791368228196 0.06893000696357324 1.0000000000000041e-14 13.999999999999998 -4.848855074431557 IQEVGEPSKEEK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQEVGEPSKEEK 12 1 Q99442;F8WF48;F8WCJ7 Q99442 SEC62 Translocation protein SEC62 1 5144100.0 2023900.0 2105100.0 1015100.0 True False 2772190.523840966 2012089.721365209 775354.2866407381 1.0 0.7258122066507134 0.2796901150814331 21.402594982049994 -7.050101517616144 0.3957920270055853 1.0272227152694706 1.649005416388806e-11 0.9998622553159093 0.003483901849682626 0.07330903903813485 0.017803627195893627 0.0059858009260791 0.03521133087060153 8.91042629945389e-08 7.050101517616144 -1.0272227152529805 down IQEVGEPSKEEK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQEVGEPSKEEK 12 1 Q99442;F8WF48;F8WCJ7 Q99442 SEC62 Translocation protein SEC62 1 6989400.0 2053500.0 2929500.0 2006400.0 True False 1707576.235474675 2913718.202039776 2425928.9634545604 1.0 1.7063473603741126 1.4206855969626424 20.703518559017322 -10.104096242378422 4.6930153398373164 0.9999700266709215 1.56351647857729 0.8384118035485479 0.11662092663322021 4.294085566757445e-05 8.197108036248582e-06 0.11292476029373197 0.03763924221227446 7.868713947407984e-11 10.104096242378422 0.5635464519063684 IQFACSVCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQFACSVCK 9 0 O43823 O43823 AKAP8 A-kinase anchor protein 8 0 4351200.0 1071000.0 2084600.0 1195600.0 False True 1404091.3715787525 1773585.8057071578 1071890.7810050284 1.0 1.2631555478565102 0.7634052902125595 20.421205391743214 -6.763592805700365 1.5986524994178288 1.1521650344895755 0.7612275512758373 0.705612821428987 0.11074935652159455 0.2769012212369958 1.3954576169854418 0.05463669276493553 0.13085450912588223 1.7234837552205916e-07 6.763592805700365 -0.3909374832137382 IQFK(ub)PDDGTTPER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQFKPDDGTTPER 13 1 Q96AE4;E9PEB5;Q96AE4-2 Q96AE4;Q96AE4-2 FUBP1 Far upstream element-binding protein 1 1 3972680.0 638100.0 955380.0 2379200.0 True False 530608.422623029 950233.1783119186 2876679.7198221176 1.0 1.7908369671451905 5.421473910273483 19.017288050832732 -6.941725957770601 0.6433056497874274 0.9601505757288817 6.452343350292214 0.9983813497533202 0.07745415218700313 0.0869879744999359 0.05108951713935376 0.07642102349860497 0.3101828571024307 1.1435997249412456e-07 6.941725957770601 5.492192774563332 IQFK(ub)PDDGTTPER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQFKPDDGTTPER 13 1 Q96AE4;E9PEB5;Q96AE4-2 Q96AE4;Q96AE4-2 FUBP1 Far upstream element-binding protein 1 1 12967400.0 1759200.0 2305900.0 8902300.0 True False 2277319.0790162967 2177574.637950995 7282172.74531167 1.0 0.9562009373282961 3.197695400882187 21.11890501339594 -6.902446327069627 0.9456928370706572 0.9129585955160532 3.4450081328439848 0.9877440274002802 0.11585232779628442 0.10962629082066107 0.16744655133736833 0.0914413517831524 0.2409665605683923 1.2518539757100154e-07 6.902446327069627 2.5320495373279317 up IQFNDLQSLLCATLQNVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQFNDLQSLLCATLQNVLR 19 0 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 0 8953800000.0 4171300000.0 2820100000.0 1962400000.0 False True 6328167062.878153 2316831121.458133 1574530779.8495266 1.0 0.36611408934649725 0.24881308666547822 32.55914054128185 -13.999999999999988 0.2372624147384314 5.140753446620962 0.1955833654866361 0.9995205261046602 0.007225060306730213 13.528357512490398 0.15418147684875871 26.498857471175505 0.058254390291882764 1.0000000000000286e-14 13.999999999999988 -4.945170081134326 IQFNDLQSLLCATLQNVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQFNDLQSLLCATLQNVLR 19 0 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 0 5536507000.0 4171300000.0 49207000.0 1316000000.0 False True 5399830078.615668 46468587.19357062 1076501503.300289 1.0 0.008605564715377781 0.19935840343632943 32.3302668633743 -10.343824578274797 5.387639433888773 1.0002612643565167 0.10398198407582912 0.9671259773518911 0.07787452030904372 0.0002444543846776474 2.9772641354395592e-05 0.07542286309585311 0.025133893354222316 4.530805528073742e-11 10.343824578274797 -0.8962792802806876 IQGEYK(ub)YTQVGPDHNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQGEYKYTQVGPDHNR 16 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 6552100.0 1716000.0 1412400.0 3423700.0 True False 1661526.5192909117 1976378.6855686968 2526930.26120161 1.0 1.18949572132749 1.5208485882488507 20.664077889103538 -6.962584238472874 0.39733838301191365 0.9812416852782715 1.7411497231824624 0.9998543634821696 0.0025976095173735254 0.07879056917401013 0.017812655546289278 0.004265601304613156 0.027790005716567832 1.0899730538918933e-07 6.962584238472874 0.7599080379041909 IQGEYK(ub)YTQVGPDHNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQGEYKYTQVGPDHNR 16 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 5561400.0 1528200.0 1619100.0 2414100.0 True False 2093216.838052158 1547562.8083522937 1843939.2999501585 1.0 0.7393227401096093 0.8809117461839431 20.997290338623838 -10.075344117987001 4.762554291925766 1.000007494824918 0.8101172432972881 0.7057099791116486 0.057803469688451445 4.600175978496369e-06 8.931495272897437e-07 0.055970177359398146 0.01865598961992752 8.407287170531539e-11 10.075344117987001 -0.18989025152762995 IQGEYK(ub)YTQVGPDHNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQGEYKYTQVGPDHNR 16 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 8172900.0 1716000.0 3788000.0 2668900.0 True False 1426930.0316895775 3767593.2921408694 3226954.6504006605 1.0 2.6403490069374986 2.2614666302732007 20.444483164537814 -10.429003771754079 7.108998693448973 0.9998734015523341 2.4509078186053497 0.9513448939524268 0.15467808256008503 0.00031038691141426893 2.4930212170483575e-05 0.14977882984812751 0.04992213648154208 3.723884721268132e-11 10.429003771754079 1.4510344170530156 IQHILCTGNLCTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQHILCTGNLCTK 13 0 F8VXU5;Q9UBQ0;Q9UBQ0-2 F8VXU5 VPS29 Vacuolar protein sorting-associated protein 29 0 29486000.0 4726000.0 10567000.0 14193000.0 False True 6195831.766649098 8990444.789843392 12724444.508869495 1.0 1.451047273142103 2.0537104602101355 22.562866540966805 -6.967108167301956 0.31980956919703146 0.9172807650753732 2.6069101327937423 0.9999502399527633 0.0030449397979582064 0.07725265732586417 0.012374745696168253 0.009142248709370214 0.05302056510688097 1.0786780284558649e-07 6.967108167301956 1.6896293677183691 IQHILCTGNLCTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQHILCTGNLCTK 13 0 F8VXU5;Q9UBQ0;Q9UBQ0-2 F8VXU5 VPS29 Vacuolar protein sorting-associated protein 29 0 22846500.0 4726000.0 8298900.0 9821600.0 False True 6473329.915347796 7932227.157207602 7501940.362201437 1.0 1.2253704447228722 1.1588997409841386 22.626076602489697 -10.116035559815426 4.330791012338815 0.9999723704989325 1.1921350928699808 0.9176287839757725 0.027136551226038915 18919375.068227183 0.3126375697425058 5383.051503077828 0.00928956326587714 7.655339228094907e-11 10.116035559815426 0.19216272237104826 IQHSITAQDHQPTPDSCIISMVVGQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQHSITAQDHQPTPDSCIISMVVGQLK 27 0 P61970;H3BRV9 P61970 NUTF2 Nuclear transport factor 2 0 64767600.0 5055900.0 38605000.0 21106700.0 False True 7670169.935800744 31715636.12775826 16934951.493604746 1.0 4.134932653802701 2.2078978217366947 22.870827110914327 -9.612605500798042 6.867781892995354 1.0000613232172324 3.17141523777134 0.6286606841214486 0.7867086766594206 9.446448205363354e-09 2.8111061579800276e-17 0.7617273890414757 0.25390913346380095 2.4400262537243595e-10 9.612605500798042 2.171353914554108 IQHSITAQDHQPTPDSCIISMVVGQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQHSITAQDHQPTPDSCIISMVVGQLK 27 0 P61970;H3BRV9 P61970 NUTF2 Nuclear transport factor 2 0 31207500.0 5055900.0 9669600.0 16482000.0 False True 6544962.21668855 9131478.259738458 13482445.11960134 1.0 1.395191898351182 2.0599729491521552 22.641953433006776 -6.963282636256202 0.38639517390350325 0.9574954707920419 2.521418290346076 0.9998732494998867 0.0049240915227084184 0.07854867242180512 0.016945495573278957 0.008603051877895724 0.056007806051002494 1.0882216546781383e-07 6.963282636256202 1.5639228195540338 up IQIADLMEEK(ub)FR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQIADLMEEKFR 12 1 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18;H3BVE6 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 8208100.0 1832000.0 4327200.0 2048900.0 True False 2401769.741113236 3681598.6272934927 1836899.482436602 1.0 1.5328691024257168 0.764810818869417 21.195666415089903 -6.720140859808082 1.7591615376081722 1.3241531557453545 0.7660291012093493 0.51299695805492 0.22423004184323977 0.3550570818100887 2.147519960159209 0.10121291002802371 0.2540062903221993 1.9048427978196259e-07 6.720140859808082 -0.5581240545360052 IQIADLMEEK(ub)FR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQIADLMEEKFR 12 1 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18;H3BVE6 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 8437500.0 2251400.0 3001300.0 3184800.0 True False 2179930.5393540515 4199734.74157274 2350605.338047985 1.0 1.926545211306223 1.0782936867082504 21.055850735461252 -10.409446807643866 4.263934940649077 0.998478891750252 1.5024194490093028 0.3186893258484993 0.34629723481545266 0.005031080923017422 0.0006968025982628091 0.3362413836408472 0.11176695193770214 3.895410157368535e-11 10.409446807643866 0.5039405572590508 IQIADLMEEK(ub)FR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQIADLMEEKFR 12 1 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18;H3BVE6 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 8066900.0 2251400.0 3521800.0 2293700.0 True False 1872138.8539311823 3502827.36437743 2773302.0651294463 1.0 1.8710296819181287 1.4813549002019644 20.83625601089553 -10.083030328917676 4.420517972922886 0.9999459753054776 1.6761922905731264 0.8005941670403157 0.15908406367823902 36850067.01621248 2.944947198848232 22423.992974479937 0.05445870635417086 8.259802653024458e-11 10.083030328917676 0.6762463152676488 IQIADLMEEK(ub)FR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQIADLMEEKFR 12 1 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18;H3BVE6 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 18427200.0 2454600.0 3867600.0 12105000.0 True False 3177528.087399618 3652364.6601063623 9902014.207788754 1.0 1.149435838062201 3.116263313943585 21.599473447150174 -6.922103936602856 0.8089677078015307 0.9598057002613152 3.4493080383960213 0.9947457026137183 0.06990060628874123 0.09694965057473307 0.09931459113919362 0.060907444459511816 0.18628415326512412 1.196454158195016e-07 6.922103936602856 2.489502338134706 up IQIEAIPLALQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQIEAIPLALQGR 13 0 Q9H0S4;Q9H0S4-2 Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 0 5954800.0 1231700.0 2318600.0 2404500.0 False True 1614770.6277997685 1972673.9178320132 2155705.405592664 1.0 1.2216434234501228 1.3349917124328394 20.622897819297712 -13.257874562576347 0.09166690665815545 9.851722374549781e-12 1.6213049715689265 0.9998530326028937 0.0016865614247045416 9.464245078012592 0.08141611129913771 1.9645435448245878 0.2425789671176754 5.522369190264342e-14 13.257874562576347 1.6213049715590748 IQIEAIPLALQGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQIEAIPLALQGR 13 0 Q9H0S4;Q9H0S4-2 Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 0 4149500.0 1252000.0 1086700.0 1810800.0 False True 1212255.9453101526 1520624.977065634 1336497.157164436 1.0 1.2543761760447263 1.1024876077819497 20.20926289853661 -10.288020972385935 4.961031023668885 0.9999476053327966 1.178431891913324 0.6478955676325717 0.06200824833460716 3.594780261109381e-05 5.159203874945182e-06 0.060056838262814945 0.020013076093905853 5.152037644289364e-11 10.288020972385935 0.1784842865805275 IQIEAIPLALQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQIEAIPLALQGR 13 0 Q9H0S4;Q9H0S4-2 Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 0 7189800.0 1231700.0 2364100.0 3594000.0 False True 1687092.7754409423 2259646.2449667444 2745171.220753439 1.0 1.3393728417669017 1.6271607944239788 20.686107880820604 -6.973035714209279 0.17075103371648814 0.7482903047420146 2.2259558099830374 0.9999974104464686 0.00041244145849721073 0.07532941071230163 0.005330422305202829 0.01204482825813262 0.033259411546439806 1.0640555120150273e-07 6.973035714209279 1.4776655052410228 IQK(ub)AQGMPEGGGALAEGFQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQKAQGMPEGGGALAEGFQVR 21 1 O95140 O95140 MFN2 Mitofusin-2 1 11433000.0 2716400.0 3603100.0 5113500.0 True False 2258806.956923989 3583689.3851406486 6182709.207847341 1.0 1.586540794978277 2.7371569708050068 21.107129549134925 -6.9604212350754 0.4294554566402309 0.954030921977091 3.4137514945065486 0.9997855056774003 0.010567495251451717 0.0795509801242937 0.020577810079961373 0.014995990993413982 0.09554888660670434 1.095415205075809e-07 6.9604212350754 2.4597205725294575 IQK(ub)DKPETWENQWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQKDKPETWENQWK 14 2 Q15800;D6RDP9;D6R952 Q15800 MSMO1 Methylsterol monooxygenase 1 1 6396600.0 1306200.0 1558900.0 3531500.0 True False 1712440.8492587944 1326318.1965446065 3166094.2565400247 1.0 0.7745191298833384 1.8488780257200845 20.70762272501496 -6.851906379416147 1.2258780931089386 0.8794523298142128 1.8934268752987065 0.9430311951333575 0.11040523027551093 0.15537233418802024 0.44835860516193593 0.07043802651579784 0.16320657303011687 1.40635065756788e-07 6.851906379416147 1.0139745454844937 IQK(ub)HQEHILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQKHQEHILR 10 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 3545550.0 802810.0 1901200.0 841540.0 True False 1052491.6844231 1617548.3708195572 754465.5134216882 1.0 1.5368752026826518 0.7168375053102978 20.005377404146536 -6.729998258773552 1.7227078952876806 1.323065555845326 0.7172722455631015 0.5595869049961741 0.225688136898591 0.33619316133704086 1.9545407184464583 0.10380765501685407 0.2576441433804499 1.862094602384873e-07 6.729998258773552 -0.6057933102822244 IQK(ub)HQEHILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQKHQEHILR 10 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 5881700.0 1606200.0 2549100.0 1726400.0 True False 1555212.0601894287 3566968.923380893 1274204.0491101611 1.0 2.293557910646878 0.8193120936542634 20.568679881078562 -6.67492818108873 1.919691710036634 1.822145380023413 0.8251107055825055 0.30111341505977607 0.5488593550813623 0.4499258820805565 3.2010639546589004 0.22978208775802872 0.6100492932006268 2.113838574632518e-07 6.67492818108873 -0.9970346744409075 IQK(ub)HQEHILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQKHQEHILR 10 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 4507810.0 802810.0 2020600.0 1684400.0 True False 1099630.552124497 1931323.210769344 1286579.4113069265 1.0 1.756338260189305 1.170010608400469 20.068587465669427 -10.522870099479551 5.645807903241456 0.9990625228150845 1.4631744342948791 0.45416206636681256 0.23936726149448445 0.002829871192274226 0.00023915391057888772 0.23220077465071054 0.07725545144961765 3.000059723670503e-11 10.522870099479551 0.4641119114797947 IQK(ub)LLQDFFNGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQKLLQDFFNGK 12 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;P54652;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 37557600.0 12505000.0 15626000.0 9426600.0 True False 16394176.09859228 13294661.709670931 8451225.858332211 1.0 0.8109380812868361 0.5155017127733484 23.966680064061293 -6.964568356263015 0.365384822029165 1.023941880851226 0.2922883324927721 0.9999039682895886 0.0019538152722564112 0.07810773647766417 0.015378282405893956 0.003923586466038059 0.02515509572514059 1.0850047606612918e-07 6.964568356263015 -0.7316535483584539 IQK(ub)LLQDFFNGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQKLLQDFFNGK 12 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;P54652;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 58354000.0 22789000.0 10875000.0 24690000.0 True False 22065575.66906791 15217444.212375792 18222948.315876894 1.0 0.6896463722769759 0.8258541988289156 24.39529405050462 -10.12985755014676 4.850356875214612 1.000014580143401 0.7577502855516063 0.8083394888744393 0.055606612342247806 8.76777704643961e-06 1.5728957067994965e-06 0.05384410962231206 0.017946956961053723 7.415534330978454e-11 10.12985755014676 -0.24226429459179477 IQK(ub)LLQDFFNGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQKLLQDFFNGK 12 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;P54652;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 59365000.0 17134000.0 13905000.0 28326000.0 True False 25993530.663187556 11423544.109739134 22727353.684273183 1.0 0.4394764319537913 0.8743465433289529 24.631649270485028 -9.89175790843063 6.593660766512359 1.0000000169057237 0.6569114876413675 0.4535255919312925 0.17753497954278646 4.4021533195999125e-08 7.3810258201871435e-09 0.17189751246900672 0.05729916826153362 1.2830455997191107e-10 9.89175790843063 -0.3430885292643562 IQK(ub)LLQDFFNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQKLLQDFFNGK 12 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;P54652;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 54828000.0 12505000.0 26878000.0 15445000.0 True False 17128436.434918396 25690441.086339872 11797209.09975983 1.0 1.499870766602303 0.6887499127304924 24.029890125584185 -6.7399904267391975 1.6868708960564027 1.2974251865783757 0.6882879063737192 0.6048530336743412 0.21002383604063987 0.31782704043410676 1.7757941664869494 0.098498978847133 0.24169715152975227 1.8197409711686995e-07 6.7399904267391975 -0.6091372802046565 IQK(ub)LLQDFFNGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQKLLQDFFNGK 12 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;P54652;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 75438400.0 22789000.0 43477000.0 9172400.0 True False 18950063.223877467 43242780.77149115 11090306.431614142 1.0 2.2819333244758973 0.5852384923782274 24.175699325938897 -6.704691938361648 1.8149801854450895 1.7923785387539866 0.5899538114190253 0.43952861427478473 0.5406722895673289 0.38581619330582306 2.474192622545859 0.23741250861136137 0.606860405390281 1.973822347122318e-07 6.704691938361648 -1.2024247273349613 IQK(ub)LLQDFFNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQKLLQDFFNGK 12 1 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;P54652;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 45068300.0 17134000.0 19392000.0 8542300.0 True False 22180300.761633262 18312818.153062005 6987689.051399741 1.0 0.8256343477875152 0.3150403200792845 24.402775592577477 -6.951993231530781 0.5365149606678925 1.0076944657803326 0.10954128348620924 0.9993485655735841 0.007418234877315954 0.08269509567780849 0.03272527511406509 0.008198838001988111 0.04226170005341639 1.116880654203476e-07 6.951993231530781 -0.8981531822941233 down IQK(ub)LSLQNCCLTGAGCGVLSSTLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQKLSLQNCCLTGAGCGVLSSTLR 24 1 P13489;E9PMJ3;E9PLZ3;E9PIM9;E9PIK5 P13489 RNH1 Ribonuclease inhibitor 1 52650000.0 14050000.0 17701000.0 20899000.0 True False 21314877.19258696 14542118.251455743 16768303.489642883 1.0 0.682252030826305 0.7866948206239107 24.345357407331534 -10.74107462710477 9.97035333273245 1.0006958738840042 0.7344734257251079 0.8960264131717476 0.04263859038614912 0.0006611073555288848 1.7168604638415977e-05 0.04138228076801871 0.013761545872609608 1.8152037199712034e-11 10.74107462710477 -0.2662224481588963 IQK(ub)YSEGEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQKYSEGEIR 10 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0 Q9Y5K5-3 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 40233200.0 15830000.0 15975000.0 8428200.0 True False 20753283.297938045 13591592.270062277 7556130.713003158 1.0 0.6549128672768939 0.3640932668111316 24.3068362620175 -7.49680911998946 0.22417949712586546 1.1635742736601598 9.039956399461909e-15 0.9999195421033353 0.0023314564414366906 0.12736211704637002 0.021220393105672336 0.029079485992719676 0.065054899065735 3.185597339754431e-08 7.49680911998946 -1.1635742736601506 down IQK(ub)YSEGEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQKYSEGEIR 10 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0 Q9Y5K5-3 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 70266000.0 24364000.0 18701000.0 27201000.0 True False 36961969.2469885 15363660.438420095 21824710.4273782 1.0 0.41566130678147944 0.5904639517862372 25.13953828641956 -10.924821677121518 11.619623357204766 1.0664902339924962 0.5030626292838588 0.9150794581495084 0.07136288099175389 0.03348874973990616 0.00021667001256103676 0.018824897279404666 0.023032270801537056 1.1889903309339413e-11 10.924821677121518 -0.5634276047086374 IQK(ub)YSEGEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQKYSEGEIR 10 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0 Q9Y5K5-3 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 36020400.0 15830000.0 11703000.0 8487400.0 True False 21682778.789664745 11185922.763354266 6482850.923489913 1.0 0.5158897239078101 0.2989861671503106 24.370046323540393 -11.520202539333681 0.14292493311886958 2.18601158631978 4.997029033221169e-13 0.9996648457092311 0.005364669330798643 4.291888057664106 0.09118437651162553 1.8060891356317088 0.22036095847639872 3.0185436518472363e-12 11.520202539333681 -2.1860115863192804 IQK(ub)YSEGEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQKYSEGEIR 10 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0 Q9Y5K5-3 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 61349100.0 18197000.0 34447000.0 8705100.0 True False 15131611.763785105 34261427.17380585 10525296.162165217 1.0 2.2642285374916007 0.6955832813101703 23.851062330535196 -6.69222451010959 1.8583832999116683 1.7909553734809356 0.7008478922363123 0.3807949537991264 0.5344453268075472 0.41197275448501797 2.7601953482191894 0.2299101629678966 0.5970569567305543 2.0313066481166053e-07 6.69222451010959 -1.0901074812446234 IQK(ub)YSEGEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQKYSEGEIR 10 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0 Q9Y5K5-3 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 60769000.0 24364000.0 22314000.0 14091000.0 True False 31539678.286239777 21072206.28441754 11526582.585869579 1.0 0.6681173502524591 0.36546290933152703 24.910664608512008 -7.332629106750368 0.2380657116089279 1.1336531059355768 4.2813691002562215e-13 0.9999451397347422 0.0019193841163569717 0.11052616416570515 0.016484532393692214 0.018109424400207377 0.05039169211984132 4.6491214687354264e-08 7.332629106750368 -1.1336531059351487 down IQLFLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQLFLAR 7 0 J3KT14;A0A087WY84;A0A087WWS1;Q96FV9-2;Q96FV9 J3KT14 THOC1 THO complex subunit 1 0 7277800.0 2141600.0 2597000.0 2539200.0 False True 2807658.3392839045 2209537.7230267115 2276467.9417263013 1.0 0.7869681620842285 0.810806610574603 21.420935955746376 -9.975839731483152 5.5764185093320915 1.0000003911046838 0.7988873864157624 0.9895723529788614 0.009732005844293776 4.7321450341554543e-08 8.699664246790375e-09 0.009422992463407396 0.0031409913798975237 1.0572075805546376e-10 9.975839731483152 -0.20111300468892135 IQLFLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQLFLAR 7 0 J3KT14;A0A087WY84;A0A087WWS1;Q96FV9-2;Q96FV9 J3KT14 THOC1 THO complex subunit 1 0 3690080.0 1721900.0 514880.0 1453300.0 False True 1667239.2270204083 720474.2690637297 1072637.1319345436 1.0 0.43213610703685207 0.6433612612699243 20.66902969636828 -10.144692850723917 5.27728834814287 1.0000141636668554 0.5377486841531322 0.8646019430046296 0.08623230811952463 1.4370519606229645e-05 2.3291878601141564e-06 0.083496628810977 0.027831357770864644 7.166500727207783e-11 10.144692850723917 -0.4622654795137232 IQLFLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQLFLAR 7 0 J3KT14;A0A087WY84;A0A087WWS1;Q96FV9-2;Q96FV9 J3KT14 THOC1 THO complex subunit 1 0 7321700.0 2141600.0 2212900.0 2967200.0 False True 2933407.3945638733 2115126.7609182796 2266408.4714022265 1.0 0.7210477361030679 0.7726197443976875 21.484146017269268 -10.572913506422063 6.3822190734487885 1.000476043084045 0.7468337402503793 0.9698166547840033 0.02105418422206662 0.00014287387246846747 9.560867291015435e-06 0.020422958558487993 0.006795208738337248 2.673538814488958e-11 10.572913506422063 -0.2536423028336656 IQLFLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQLFLAR 7 0 J3KT14;A0A087WY84;A0A087WWS1;Q96FV9-2;Q96FV9 J3KT14 THOC1 THO complex subunit 1 0 4166120.0 1721900.0 673820.0 1770400.0 False True 1431836.1431038943 670189.9979172027 2140582.4545952724 1.0 0.4680633333255463 1.494991214535888 20.449434971802557 -6.76592230550527 1.590011117559786 0.6933077936320715 1.4999042858743292 0.7147300871491025 0.22396799930258462 0.27308022195115333 1.3618247197739894 0.11107044398564463 0.26540063659923613 1.7142639587894075e-07 6.76592230550527 0.8065964922422577 IQLIFER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQLIFER 7 0 A0A499FI31;Q15020-4;Q15020;Q15020-2 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 13991100.0 4062000.0 4287000.0 5642100.0 False True 5325321.336463961 3647396.3105951212 5058309.614844823 1.0 0.6849157224786383 0.9498599793798669 22.344437151289114 -10.058383909769024 6.717197416646731 1.0000000863990544 0.8173878517840352 0.38778609912228024 0.10816303994814624 1.399469307560077e-07 1.974767008502664e-08 0.10472846303681284 0.03490947103286133 8.742106445408586e-11 10.058383909769024 -0.1826122346150192 IQLIFER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQLIFER 7 0 A0A499FI31;Q15020-4;Q15020;Q15020-2 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 9880200.0 3127100.0 1653300.0 5099800.0 False True 3027831.922187995 2313471.3118456006 3764009.389279427 1.0 0.7640686046317334 1.2431368338832525 21.529853691505142 -6.772751674916967 1.563614375114269 0.8651586221856614 1.2461384274297151 0.741132239918742 0.09951237722639329 0.2619752441678605 1.2643642588283475 0.05015060802971589 0.11909544755543314 1.6875176546827718e-07 6.772751674916967 0.3809798052440537 IQLIFER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQLIFER 7 0 A0A499FI31;Q15020-4;Q15020;Q15020-2 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 12862000.0 4062000.0 3371400.0 5428600.0 False True 5563831.171422512 3222440.400271092 4146476.485526466 1.0 0.5791765244104642 0.7452556265229613 22.407647212812005 -10.102568916180743 5.1395770800719545 1.0000082456092054 0.6622160754660944 0.8465203825419201 0.06780150952135434 6.406247738362951e-06 1.1184606594857049e-06 0.06565013104494828 0.021882843101684576 7.896435345805291e-11 10.102568916180743 -0.337792170143111 IQLIFER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQLIFER 7 0 A0A499FI31;Q15020-4;Q15020;Q15020-2 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 6432700.0 3127100.0 1490000.0 1815600.0 False True 2600322.204018921 1481973.074258158 2195233.5656140842 1.0 0.5699190169463224 0.8442159830121232 21.31025896693942 -10.57058463988865 6.401874042661599 1.0005220408770905 0.707067499979223 0.6032783528695902 0.11198126747578742 0.0008358076471065515 5.606304670269656e-05 0.10861218121669783 0.03614179866841023 2.6879139429990192e-11 10.57058463988865 -0.2934545408978675 IQLINNMLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQLINNMLDK 10 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 75254000.0 13506000.0 43250000.0 18498000.0 False True 17706496.792290073 36797268.587179594 16584004.405345457 1.0 2.0781789316564416 0.9366056199533844 24.077775469168273 -6.659101865850906 1.9764510283580745 1.6945331936929882 0.9414068649479126 0.23168563216496696 0.45916461681142456 0.48654574439203113 3.652842545301897 0.18777285049196485 0.5088388138273454 2.1922906627647117e-07 6.659101865850906 -0.7531263287450756 IQLINNMLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQLINNMLDK 10 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 98821000.0 41662000.0 22551000.0 34608000.0 False True 40339462.614625804 31555731.901911426 25543126.582254663 1.0 0.782254642392542 0.633204433739619 25.26568852931317 -7.750221104973032 0.08544899576647898 1.527553635920596 7.423390135961161e-11 0.9999969898340393 0.00026125329202653487 0.13551241893785476 0.010608120928110865 0.08241978760937642 0.10133585545641496 1.7773742952695657e-08 7.750221104973032 -1.527553635846362 IQLINNMLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQLINNMLDK 10 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 64482000.0 13506000.0 23828000.0 27148000.0 False True 18499533.18592626 22775200.17134111 20736201.530610546 1.0 1.231122966317205 1.1209040423996137 24.140985530691164 -10.117056499667637 4.087122107797282 0.9999614736201213 1.176013504304597 0.772743226044772 0.044996687511678304 15811250.537818667 13535725.22964931 6957.867561484206 0.01646710148546236 7.637364186016328e-11 10.117056499667637 0.1760520306844756 IQLINNMLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQLINNMLDK 10 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 53418400.0 41662000.0 6545700.0 5210700.0 False True 34643798.93954027 6510437.014880278 6300233.2784453165 1.0 0.1879250317276744 0.18185745995814057 25.046093804747446 IQLINNMLDKVNEMIIGGGMAFTFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQLINNMLDKVNEMIIGGGMAFTFLK 26 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 53769600.0 30631000.0 14284900.0 8853700.0 False True 39652433.327278405 13489932.757563714 7242417.446633566 1.0 0.3402044118256793 0.18264749068126504 25.24090606586539 -13.999999999999908 0.2011755041633487 4.684223408191328 0.08149986601206202 0.9994870178562294 0.008019117236525703 12.55439702365161 0.1422154002571851 18.208988190129823 0.09945180829072418 1.0000000000002127e-14 13.999999999999908 -4.602723542179266 IQLLCLMEMTFTRPANHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQLLCLMEMTFTRPANHR 18 1 Q9UNM6;A0A087WUL9;Q9UNM6-2;E9PL38 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 0 49590600.0 7610600.0 15561000.0 26419000.0 False True 11545836.60938808 12784017.971352084 21197273.07014094 1.0 1.1072405061541597 1.8359235270058423 23.460869378552303 -6.933262919322808 0.7195044123755019 0.9901483628320497 1.998757961779944 0.997141602080225 0.019854972225711812 0.09097849218569398 0.06963713432659834 0.018453691571659263 0.06479089732463136 1.1661034511632905e-07 6.933262919322808 1.0086095989478943 IQLLVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQLLVFK 7 0 B0QY89;Q9Y262;Q9Y262-2;B0QY90 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 32553300.0 8922100.0 8504200.0 15127000.0 False True 11696959.501739312 7235406.509111969 13561803.148430116 1.0 0.6185715619547182 1.1594297771496522 23.479630229761558 -6.717208922895131 1.7693382028020896 0.7672557284744187 1.1584588671081542 0.49933147591727167 0.16056372017115939 0.36076460794319437 2.205653430079288 0.07209789286970948 0.1815909264767909 1.9177459625961118e-07 6.717208922895131 0.39120313863373546 IQLLVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQLLVFK 7 0 B0QY89;Q9Y262;Q9Y262-2;B0QY90 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 41495100.0 8922100.0 15817000.0 16756000.0 False True 12220841.480686553 15118152.64017555 12798577.90065236 1.0 1.237079514047197 1.0472746840615554 23.54284029128445 -10.279050504337 4.3857137984104675 0.9999020640758934 1.142177099056003 0.42796379431127085 0.07748749736929446 7.425467102379156e-05 1.220636033991403e-05 0.07507855432205386 0.02500898223672704 5.2595609911881913e-11 10.279050504337 0.14227503498010952 IQLTFEATLQQLEAPYNSDTVLVHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQLTFEATLQQLEAPYNSDTVLVHR 25 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 37492700.0 8493700.0 12781000.0 16218000.0 False True 12885563.872645961 10500130.691591218 13012505.191398073 1.0 0.8148755301179605 1.0098514368487659 23.619252335166962 -13.173812912977311 15.018701424699659 8.79988897153007 0.9211271351350682 0.0 0.0919824876363186 0.0 0.0 0.0 0.026630737900375456 6.701732470128575e-14 13.173812912977311 -7.878761836395002 IQLVAVNYIPEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQLVAVNYIPEVR 13 0 Q9UJW0-2;Q9UJW0;Q9UJW0-3 Q9UJW0-2 DCTN4 Dynactin subunit 4 0 2635150.0 681940.0 1523000.0 430210.0 False True 894029.9439163537 1295774.3366075042 385695.9960657185 1.0 1.449363464193698 0.43141283878720343 19.769963627116287 -6.786705670631744 1.5094610595009341 1.25222717247514 0.4215450285844529 0.7904849930045601 0.1906554794068703 0.2402932032422872 1.0816374807533138 0.0994382506580531 0.2333810558799542 1.6341590723902951e-07 6.786705670631744 -0.8306821438906871 down IQLVAVNYIPEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQLVAVNYIPEVR 13 0 Q9UJW0-2;Q9UJW0;Q9UJW0-3 Q9UJW0-2 DCTN4 Dynactin subunit 4 0 3834940.0 681940.0 1293000.0 1860000.0 False True 934071.6467355646 1235870.9846207865 1420706.3079024483 1.0 1.3231008445015582 1.5209821568480282 19.833173688639178 -9.990114768948796 0.08460583143748823 3.524557774238176e-15 2.2179747721719405 0.9999613716767913 0.001334559164691937 1.6213593039383019 0.040028606088120734 0.7053519209366286 0.3631290476876221 1.0230226072094735e-10 9.990114768948796 2.217974772171937 IQLVEEELDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQLVEEELDR 10 0 J3KN67;A0A2R2Y2Q3;P06753;A0A494C0P6;Q5TCU3;CON__Q3SX28;A7XZE4;P07951-3;P07951;P07951-2;A0A2R8YEU4;H0YL80;H0YKX5;Q6ZN40;H0YKP3;A0A0S2Z4G6;P09493-2;P09493-9;P09493-8;P09493-7;P09493-6;P09493-4;P09493;P09493-3;P09493-10;P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;A0A494C0G0;P67936;A0A2R8Y5V9;A0A2R8YE05;K7ENT6;P67936-2;A0A2R8YH90;A0A2R8YGX3;A0A2R8YHD2;F5H7S3;H7BYY1;H0YKJ4;H0YK48;A0A494BZZ2;B7Z596;P09493-5 J3KN67;P06753-2;P67936;F5H7S3 TPM3;TPM2;TPM2b;TPM1;TPM4 Tropomyosin alpha-3 chain;Tropomyosin beta chain;Tropomyosin alpha-1 chain;Tropomyosin alpha-4 chain 0 58161400.0 3683400.0 22571000.0 31907000.0 False True 4828973.070096344 19203494.781068917 28605569.71355593 1.0 3.9767243474575404 5.923737676380377 22.20328498732909 -8.25485008175046 0.2831953399938692 3.2282501843198894e-19 7.204260204138661 0.999101190553747 0.060701017375769606 0.09898675136256846 0.06774847877518256 0.5724597866875637 0.6277233643364352 5.560961882821665e-09 8.25485008175046 7.204260204138661 IQLVEEELDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQLVEEELDR 10 0 J3KN67;A0A2R2Y2Q3;P06753;A0A494C0P6;Q5TCU3;CON__Q3SX28;A7XZE4;P07951-3;P07951;P07951-2;A0A2R8YEU4;H0YL80;H0YKX5;Q6ZN40;H0YKP3;A0A0S2Z4G6;P09493-2;P09493-9;P09493-8;P09493-7;P09493-6;P09493-4;P09493;P09493-3;P09493-10;P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;A0A494C0G0;P67936;A0A2R8Y5V9;A0A2R8YE05;K7ENT6;P67936-2;A0A2R8YH90;A0A2R8YGX3;A0A2R8YHD2;F5H7S3;H7BYY1;H0YKJ4;H0YK48;A0A494BZZ2;B7Z596;P09493-5 J3KN67;P06753-2;P67936;F5H7S3 TPM3;TPM2;TPM2b;TPM1;TPM4 Tropomyosin alpha-3 chain;Tropomyosin beta chain;Tropomyosin alpha-1 chain;Tropomyosin alpha-4 chain 0 42162900.0 12993000.0 5182900.0 23987000.0 False True 12580544.327008635 7252458.9984664405 17704085.105424836 1.0 0.5764821306576096 1.407259069658591 23.584691009392717 -6.768130168683902 1.5815827808184706 0.7564961500239242 1.4116061658906272 0.7233334602644801 0.1784082149206887 0.2694822337663281 1.3300364871681476 0.0889288076499354 0.2120551244496593 1.705571110986475e-07 6.768130168683902 0.6551100158667029 IQLVEEELDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQLVEEELDR 10 0 J3KN67;A0A2R2Y2Q3;P06753;A0A494C0P6;Q5TCU3;CON__Q3SX28;A7XZE4;P07951-3;P07951;P07951-2;A0A2R8YEU4;H0YL80;H0YKX5;Q6ZN40;H0YKP3;A0A0S2Z4G6;P09493-2;P09493-9;P09493-8;P09493-7;P09493-6;P09493-4;P09493;P09493-3;P09493-10;P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;A0A494C0G0;P67936;A0A2R8Y5V9;A0A2R8YE05;K7ENT6;P67936-2;A0A2R8YH90;A0A2R8YGX3;A0A2R8YHD2;F5H7S3;H7BYY1;H0YKJ4;H0YK48;A0A494BZZ2;B7Z596;P09493-5 J3KN67;P06753-2;P67936;F5H7S3 TPM3;TPM2;TPM2b;TPM1;TPM4 Tropomyosin alpha-3 chain;Tropomyosin beta chain;Tropomyosin alpha-1 chain;Tropomyosin alpha-4 chain 0 43634400.0 3683400.0 20943000.0 19008000.0 False True 5045252.520142214 20017669.01076032 14518701.882048227 1.0 3.9676247979350032 2.8776957791676554 22.266495048851983 -10.580125402584272 10.005932145444259 0.999847605136112 3.4226602885512705 0.8682060534376604 0.4449616586387257 0.0015130744495426888 6.349061522576762e-05 0.4308540570499645 0.14361075780071791 2.6295086113349072e-11 10.580125402584272 2.4228126834151587 IQNEQLEK(ub)LQEQVTDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQNEQLEKLQEQVTDLR 17 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 15397300.0 3928000.0 4506400.0 6962900.0 True False 3803307.7900784924 6305829.02056555 5139107.607477497 1.0 1.6579854612385738 1.351220540415804 21.858823265918684 -9.997230474603978 4.37811252381593 0.9999801609318646 1.504603000785884 0.7829706444784161 0.1252362548721987 86970364.55326302 113465197.64997362 23337.631027355055 0.0458317864126665 1.0063974446806909e-10 9.997230474603978 0.5046228398540193 IQNEQLEK(ub)LQEQVTDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQNEQLEKLQEQVTDLR 17 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 32992400.0 7909400.0 11029000.0 14054000.0 True False 11999138.054594116 9060788.780029684 11276220.739912987 1.0 0.7551199710182995 0.9397525629431069 23.516427439293235 -10.180007828435835 6.095636136460872 1.0000015313601545 0.8474362671783422 0.4765450286481605 0.07537594001721788 1.5687129438664014e-06 2.110633980028865e-07 0.07298317306074091 0.024327480032617362 6.606815386929161e-11 10.180007828435835 -0.15256526418181227 IQNEQLEK(ub)LQEQVTDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQNEQLEKLQEQVTDLR 17 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 11782400.0 3928000.0 3694200.0 4160200.0 True False 3266306.039904809 3674298.611358709 5030078.585408531 1.0 1.1249094746387545 1.5399899837784716 21.63922854135296 -6.94913158899899 0.5682958612775445 0.9947889976174552 1.6902324544322314 0.9991313724215504 0.0068027134694181295 0.08383631007225466 0.037419810934684127 0.007221145389406529 0.03457005711337384 1.1242642760493417e-07 6.94913158899899 0.6954434568147762 IQNEQLEK(ub)LQEQVTDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQNEQLEKLQEQVTDLR 17 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 32894400.0 7909400.0 12489000.0 12496000.0 True False 10238874.217582706 11793976.171286687 10221856.21978755 1.0 1.1518821230398046 0.9983379034224356 23.287553761385684 -6.648707348585196 2.0134386828004094 1.098660033481784 0.9989870800313674 0.18868231491076237 0.06484627015892751 0.5117271769986127 3.974978291457678 0.02613505494828629 0.07180847935563063 2.2453944839201736e-07 6.648707348585196 -0.0996729534504166 IQNGAQGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQNGAQGIR 9 0 P31943;G8JLB6;E9PCY7;D6RBM0;D6RIU0;E7EN40;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;D6RDL0;D6RF17 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 20618550.0 317650.0 11319000.0 8981900.0 False True 416442.2261269756 9630249.321116427 8052539.148468604 1.0 23.125054850177726 19.336509708343886 18.667756835906385 -9.245860236811858 10.262890188433714 0.9999863715896761 21.230782279261174 0.974372521869453 1.5466670775202047 0.0 0.0 1.4975539583311093 0.49918465277703633 5.67727280095158e-10 9.245860236811858 20.2307959076715 IQNGAQGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQNGAQGIR 9 0 P31943;G8JLB6;E9PCY7;D6RBM0;D6RIU0;E7EN40;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;D6RDL0;D6RF17 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 21487650.0 317650.0 11035000.0 10135000.0 False True 435093.7891684782 10547437.212134855 7741321.736877048 1.0 24.24175539782446 17.792305773133968 18.730966897429276 -9.588978293079073 9.90292089627191 0.9999833587695517 21.017030585479226 0.9277653741621202 2.632976783730227 0.0 0.0 2.5493688085765633 0.8497896028588543 2.5764499299886225e-10 9.588978293079073 20.017047226709675 IQPEEK(ub)PVEVSPAVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQPEEKPVEVSPAVTK 16 1 Q8N0X7 Q8N0X7 SPG20 Spartin 1 15097800.0 5755000.0 4430200.0 4912600.0 True False 8730755.746856792 3639596.1966894083 3941622.4567309273 1.0 0.41687069278048694 0.4514640623350359 23.057675110355476 -10.416046812426686 6.75533634261095 1.0000642517021423 0.434167377557767 0.9972045267245289 0.014122683982029257 1.3667928637839956e-05 1.1814994605987873e-06 0.013675769058317463 0.004558076655512466 3.8366588807235104e-11 10.416046812426686 -0.5658968741443753 IQPEEK(ub)PVEVSPAVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQPEEKPVEVSPAVTK 16 1 Q8N0X7 Q8N0X7 SPG20 Spartin 1 17209200.0 5755000.0 5878500.0 5575700.0 True False 7449960.948009767 5551356.307383194 4560979.811513236 1.0 0.7451524036332325 0.6122152643943304 22.828801432447925 -13.999999999999998 0.08226589474814074 2.3561155447804127 0.231355646972098 0.9998771535251239 0.0017833336054896899 12.236222969435635 0.08135250041690648 2.989465204492693 0.34494030621924787 1.0000000000000041e-14 13.999999999999998 -2.124759897808315 IQPGNPSCTLSLK(ub)CR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQPGNPSCTLSLKCR 15 1 Q10567-3;Q10567-4 Q10567-3 AP1B1 AP-1 complex subunit beta-1 1 5460800.0 1790100.0 1732500.0 1938200.0 True False 2346838.43535306 1474017.7532321082 1737653.6565272198 1.0 0.6280865913167798 0.74042321378029 21.162287094381654 -10.528612220365702 9.198162426690041 1.0000145691848312 0.6842549025485354 0.9132954193743683 0.04586123407721242 1.370265645680826e-05 7.022386947378319e-07 0.04440699336266296 0.014801649651463644 2.960654842390691e-11 10.528612220365702 -0.31575966663629584 IQPGNPSCTLSLK(ub)CR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQPGNPSCTLSLKCR 15 1 Q10567-3;Q10567-4 Q10567-3 AP1B1 AP-1 complex subunit beta-1 1 7871500.0 1790100.0 3435200.0 2646200.0 True False 2451948.345633538 3283421.5053126994 2021222.0601997073 1.0 1.3391071272605966 0.8243330508161505 21.225497155904545 -6.728993357208871 1.7265731818009566 1.2042944337528503 0.8246753517667085 0.5547704067394654 0.1425639406068912 0.33811182366177617 1.9741009833806196 0.06544190267207622 0.16259533510940155 1.866408238434944e-07 6.728993357208871 -0.3796190819861418 IQPGNPSCTLSLK(ub)CR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQPGNPSCTLSLKCR 15 1 Q10567-3;Q10567-4 Q10567-3 AP1B1 AP-1 complex subunit beta-1 1 10423100.0 3992300.0 3194200.0 3236600.0 True False 5168111.049998158 3016439.962072535 2647572.010320455 1.0 0.5836639214773859 0.5122900774977346 22.301205639657937 -13.999999999999998 0.24810854215504985 3.8680496658077406 0.4830709783562772 0.9995391697829661 0.004616866869000793 13.923832358559222 0.15762152457353207 19.880311908228947 0.03328871551746354 1.0000000000000041e-14 13.999999999999998 -3.384978687451463 IQQAK(ub)NEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQQAKNEIR 9 1 O60749;O60749-2 O60749 SNX2 Sorting nexin-2 1 1477110.0 483010.0 625770.0 368330.0 True False 633230.787475494 532407.5552323549 330218.7448708451 1.0 0.8407796426874761 0.5214824537943437 19.272371874982074 -6.959992401119712 0.4355429483313119 1.011962006368141 0.33794287274016876 0.9997699113287297 0.003018017920674131 0.07970386820088207 0.02114153406269754 0.0041876288409869985 0.02647921132274188 1.0964973814651061e-07 6.959992401119712 -0.6740191336279722 IQQAK(ub)NEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQQAKNEIR 9 1 O60749;O60749-2 O60749 SNX2 Sorting nexin-2 1 1890830.0 635000.0 519920.0 735910.0 True False 614842.2725814262 727526.767346982 543153.0941732272 1.0 1.1832738245085979 0.8834023267346099 19.22985683326352 -6.741275494542755 1.6817999751253923 1.108882312515867 0.8831684777936778 0.6107884604198234 0.07700195874608551 0.31549469034722116 1.7525976453515617 0.0362121123671479 0.08874493978241513 1.8143643562930345e-07 6.741275494542755 -0.2257138347221893 IQQAK(ub)NEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQQAKNEIR 9 1 O60749;O60749-2 O60749 SNX2 Sorting nexin-2 1 1107640.0 483010.0 263600.0 361030.0 True False 661591.8498544525 251953.280391368 275762.14964624785 1.0 0.38082887575896934 0.4168161226697614 19.335581936504965 -10.375962290663024 7.042146816379734 1.0000242346326724 0.3988224992143657 0.9973196745685774 0.014691732029831803 5.590274680651747e-06 4.954037473415662e-07 0.0142257795506663 0.00474173612320672 4.207631612248793e-11 10.375962290663024 -0.6012017354183068 IQQAK(ub)NEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQQAKNEIR 9 1 O60749;O60749-2 O60749 SNX2 Sorting nexin-2 1 4366830.0 675400.0 682930.0 3008500.0 True False 874318.6141243792 644924.3451562818 2460983.8698168113 1.0 0.7376308072797543 2.814744911134553 19.737799588548448 -6.875209174743571 1.1061249721751323 0.8457231054309612 2.949092139864085 0.9696133684796691 0.16099143610942476 0.13196060016455718 0.29862566941427415 0.1125552676186637 0.26917712736457083 1.3328793060218175e-07 6.875209174743571 2.1033690344331237 up IQQEIAVQNPLVSER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQQEIAVQNPLVSER 15 0 J3KR44;Q96FW1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 12388500.0 3376700.0 4748000.0 4263800.0 False True 4426886.400009315 4039616.907559046 3822622.877257644 1.0 0.9125187643284782 0.8635014617157558 22.077860921696928 -13.999999437549233 0.0680671135524561 1.5146194213188582 0.6783036873905708 0.9999308118434356 0.0004695785576804065 12.380648842309853 0.06975707575145172 1.024146353767781 0.17112224166936854 1.00000129509159e-14 13.999999437549233 -0.8363157339282874 IQQEIAVQNPLVSER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQQEIAVQNPLVSER 15 0 J3KR44;Q96FW1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 10705400.0 2791200.0 1240000.0 6674200.0 False True 2702594.883825632 1735138.4665145737 4926026.798291839 1.0 0.6420268449773779 1.8227026284157135 21.365913838911002 -6.825371737571338 1.3484541848996492 0.8080297708910736 1.8515751317545155 0.8962988258475866 0.15917732130849624 0.18659240218374956 0.6651572279709252 0.092724695045197 0.21347418009495905 1.494955490088954e-07 6.825371737571338 1.0435453608634417 IQQEIAVQNPLVSER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQQEIAVQNPLVSER 15 0 J3KR44;Q96FW1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 12228300.0 3376700.0 4103100.0 4748500.0 False True 4625157.241886356 3921811.4748627585 3627002.0984273 1.0 0.847930409661761 0.784190008845632 22.14107098321982 -13.999999999988473 0.1191348791992173 1.7252744114252878 0.6812604316946134 0.9996971937199765 0.001575340603960963 11.967186199777425 0.10611363728847159 2.057359817908132 0.09133451011252419 1.0000000000265414e-14 13.999999999988473 -1.0440139797306744 IQQILTSTGFSDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQQILTSTGFSDK 13 0 Q9UNQ2;A0A494C0G7 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 0 2846900.0 0.0 1246900.0 1600000.0 False True 0.0 1060867.3803781322 1434447.3482837453 0.0 IQQILTSTGFSDK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQQILTSTGFSDKR 14 1 Q9UNQ2;A0A494C0G7 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 1 37931200.0 2876200.0 10272000.0 24783000.0 True False 4363405.678385664 8438881.344497683 19884629.18722521 1.0 1.9340125504030212 4.557135103372272 22.057023180784913 -6.952923915510418 0.525765421147505 0.9573307892110845 5.652036863703472 0.9994112137899848 0.036537627419924064 0.08233246994753281 0.031264511484854825 0.04102263545984237 0.21680545101355353 1.1144897650791024e-07 6.952923915510418 4.694706074492387 IQQLTALGAAQATAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQQLTALGAAQATAK 15 0 Q99471;H3BPF6;H3BMQ1;Q99471-3 Q99471 PFDN5 Prefoldin subunit 5 0 13039800.0 2727300.0 5219100.0 5093400.0 False True 3575516.711210771 4440430.623892459 4566383.827342772 1.0 1.2418989988131823 1.277125572655054 21.769720315504543 -12.882255270558211 0.28786710798658444 6.91473361257578e-20 1.2873155263084302 0.9995503213701387 0.002612053143614037 8.46858492041223 0.16601743202935887 4.941596988038801 0.013436690164244978 1.311428837929499e-13 12.882255270558211 1.2873155263084302 IQQLTALGAAQATAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQQLTALGAAQATAK 15 0 Q99471;H3BPF6;H3BMQ1;Q99471-3 Q99471 PFDN5 Prefoldin subunit 5 0 14245100.0 2727300.0 5726200.0 5791600.0 False True 3735656.512511228 5473197.549988816 4423743.361746142 1.0 1.4651233408795277 1.1841943569839508 21.832930377027434 -10.410525018427336 5.184750210381694 0.9997148018463009 1.3246588489317512 0.6403832901771334 0.1146887774171615 0.0003784194038900513 4.302387527612789e-05 0.1111431800049576 0.037015643744456914 3.88575112640637e-11 10.410525018427336 0.3249440470854503 IQQLTALGAAQATAK(ub)A ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQQLTALGAAQATAKA 16 1 Q99471;H3BPF6;H3BMQ1;Q99471-3 Q99471 PFDN5 Prefoldin subunit 5 1 9240600.0 2400900.0 3422400.0 3417300.0 True False 2324684.7436862155 4788982.16758023 2522206.6131974915 1.0 2.060056607928014 1.0849671638478036 21.148603651326063 -6.626273778711339 2.0934461017050934 1.7002377857725528 1.088783557621007 0.104453505309825 0.45513049829880303 0.568742608344181 4.744631333371577 0.1780945987033519 0.5044743589374198 2.3644286946086215e-07 6.626273778711339 -0.6114542281515458 IQQLTALGAAQATAK(ub)A ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQQLTALGAAQATAKA 16 1 Q99471;H3BPF6;H3BMQ1;Q99471-3 Q99471 PFDN5 Prefoldin subunit 5 1 5434500.0 1961300.0 1715200.0 1758000.0 True False 2686445.6121395784 1639416.79259209 1342796.6071465074 1.0 0.6102549722889798 0.4998413521117435 21.35726719989078 -13.999999999999782 0.1769086998765821 3.003561223313507 0.4092769751638868 0.9995021935120403 0.004786747319831357 12.166297339144442 0.1333024378038704 8.37336331730358 0.08465674077102821 1.0000000000005031e-14 13.999999999999782 -2.5942842481496204 IQQLTALGAAQATAK(ub)A ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQQLTALGAAQATAKA 16 1 Q99471;H3BPF6;H3BMQ1;Q99471-3 Q99471 PFDN5 Prefoldin subunit 5 1 7641700.0 2400900.0 3034900.0 2205900.0 True False 1996454.727904139 3018550.3913195124 2667143.491070785 1.0 1.511955342202205 1.3359398807258351 20.92900892676034 -10.178577499881593 5.598952693185547 0.999989329165601 1.4239476114640506 0.8855183026451562 0.0718580112430457 9.571947603169544e-06 1.4042261408157092e-06 0.06957797000885335 0.023192073402975827 6.628610495137702e-11 10.178577499881593 0.42395828229844956 IQQLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQQLVK 6 0 P11021 P11021;REV__Q9NXD2 HSPA5 78 kDa glucose-regulated protein 0 30837240.0 762240.0 18098000.0 11977000.0 False True 999304.0215426605 15397848.945451485 10737734.931496518 1.0 15.40857298030412 10.745213368520524 19.93056413508235 -9.73986925331212 7.433602793190949 1.0000000389918116 13.07689317441248 0.8994200963961172 1.9038085893294514 1.579297212478405e-07 2.10082470342618e-17 1.843354602869017 0.6144515800698811 1.8202487718053638e-10 9.73986925331212 12.076893135420669 IQQLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQQLVK 6 0 P11021 P11021;REV__Q9NXD2 HSPA5 78 kDa glucose-regulated protein 0 20306400.0 5899800.0 2643600.0 11763000.0 False True 5712514.078387244 3699203.2661918746 8681917.417564202 1.0 0.6475613390936681 1.5198067433061417 22.445694384995 -6.797029943060238 1.4679860212135287 0.8047994424318536 1.5309833409710163 0.8233150952603174 0.1505953595062902 0.2250425048427041 0.9577113949113336 0.08071535045708805 0.1880658081120906 1.5957691208372568e-07 6.797029943060238 0.7261838985391627 IQQLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQQLVK 6 0 P11021 P11021;REV__Q9NXD2 HSPA5 78 kDa glucose-regulated protein 0 22878240.0 762240.0 10205000.0 11911000.0 False True 1044060.7267614705 9754109.356577825 9097867.114745192 1.0 9.342473197736016 8.713925235906054 19.99377419660524 -10.109469353458483 10.637232022492814 1.000000000343713 9.028199215671222 0.995423749124537 0.25660363089162763 1.757848440636977e-08 0.0 0.24845539725490573 0.08281846575163562 7.771961606925089e-11 10.109469353458483 8.02819921532751 IQSLLDIQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQSLLDIQEK 10 0 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 0 7341600.0 1532600.0 2748800.0 3060200.0 False True 2009253.441719511 2338689.7547384817 2743559.859511197 1.0 1.1639595613866613 1.3654623167713822 20.938228122469827 -6.968357362163347 0.29479913102102895 0.9628207333233838 1.572868709254993 0.9999665798438812 0.0008640204729914833 0.0768394443510027 0.010928245933411707 0.003432317242431632 0.018174068161849834 1.0755798012532215e-07 6.968357362163347 0.6100479759316091 IQSLLDIQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQSLLDIQEK 10 0 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 0 7680000.0 1532600.0 2075800.0 4071600.0 False True 2099243.636957688 1984084.2922473548 3109971.937234196 1.0 0.9451424586060784 1.4814726039809738 21.001438183992718 -6.881686654191735 1.0703834654993098 0.9651820061717133 1.5207275900929251 0.9750191628354584 0.038081591757591494 0.12614491413761628 0.26336612796066966 0.02736397107790304 0.06646394047157966 1.3131469999433735e-07 6.881686654191735 0.5555455839212118 IQSLLDIQEK(ub)EFEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQSLLDIQEKEFEK 14 1 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 1 18625600.0 5175000.0 8657600.0 4793000.0 True False 6784475.114771286 7365919.827060479 4297066.337702496 1.0 1.0857022396652705 0.6333675435475978 22.69380577426701 -6.8576718398285434 1.1974398123931516 1.0462408345674572 0.6124171546587909 0.950747582225109 0.04353747357247425 0.14921964726631648 0.4078969521850673 0.028383628497562718 0.0660919577129005 1.387804080749677e-07 6.8576718398285434 -0.4338236799086663 IQSLLDIQEK(ub)EFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQSLLDIQEKEFEK 14 1 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 1 32500400.0 9674400.0 12115000.0 10711000.0 True False 9367291.467498817 16952582.678890385 7905467.77688771 1.0 1.809763552005384 0.843943823496566 23.159200525288863 -6.684274284443236 1.886376538564362 1.5103505303875777 0.8474538982148768 0.3439754584250553 0.3428779730511697 0.4290727446686526 2.9554185210273296 0.14564566587452552 0.38208556581481967 2.0688343363249265e-07 6.684274284443236 -0.6628966321727009 IQSLLDIQEK(ub)EFEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQSLLDIQEKEFEK 14 1 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 1 59112000.0 16089000.0 21459000.0 21564000.0 True False 24408189.263454195 17629473.79006776 17301865.948163062 1.0 0.7222770030083285 0.7088549568922238 24.54086193608064 IQSLLDIQEK(ub)EFEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQSLLDIQEKEFEK 14 1 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 1 18556100.0 5175000.0 7256900.0 6124200.0 True False 7088337.349116559 6936266.162640827 4677790.091858152 1.0 0.9785462825785676 0.6599276898751383 22.7570158357899 -6.920548274761009 0.8206625755407693 1.0068922136083482 0.60789612919723 0.9943315839861594 0.01170755438165389 0.09785027808396124 0.10395462092741678 0.010116626934068557 0.030464190898522307 1.2007475944020445e-07 6.920548274761009 -0.3989960844111182 IQSLLDIQEK(ub)EFEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQSLLDIQEKEFEK 14 1 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 1 25965900.0 9674400.0 11298000.0 4993500.0 True False 8044692.248588358 11237135.431522587 6037617.762664655 1.0 1.3968384475483724 0.7505094758253935 22.93960580072314 -6.740588769271955 1.6845774389691068 1.2359628547985126 0.7500869384089752 0.6075098614036314 0.16673321131573407 0.3167812033056882 1.7653500635752444 0.07829308955439503 0.19199744855776685 1.817235577356343e-07 6.740588769271955 -0.4858759163895374 IQSLLDIQEK(ub)EFEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQSLLDIQEKEFEK 14 1 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 1 56748000.0 16089000.0 25231000.0 15428000.0 True False 20827527.661603667 23826872.670168474 12620262.304648072 1.0 1.144008691636224 0.6059414496860327 24.311988258173088 -6.835479256882183 1.303189032900888 1.0767085108499475 0.5897662592308185 0.9164052893664119 0.06575749271190436 0.17414481852315108 0.5764331383248141 0.03959306734184703 0.0911355087019895 1.460564508417222e-07 6.835479256882183 -0.48694225161912896 IQTK(ub)EPLPTLPLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQTKEPLPTLPLGR 14 1 A0A0C4DG44;O43464-3;O43464;O43464-4 A0A0C4DG44 HTRA2 Serine protease HTRA2, mitochondrial 1 19020100.0 4058300.0 5273100.0 9688700.0 True False 5320470.600633101 4486374.03438281 8686206.264572952 1.0 0.8432287989428907 1.632601120573686 22.343122428428945 -6.855086612918542 1.2101609796961832 0.91581300863586 1.667416597202046 0.9473951125872908 0.0782610203010324 0.15195642857102198 0.4256718271365502 0.050527007305638943 0.11737828570568568 1.396089906033257e-07 6.855086612918542 0.751603588566186 IQTK(ub)EPLPTLPLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQTKEPLPTLPLGR 14 1 A0A0C4DG44;O43464-3;O43464;O43464-4 A0A0C4DG44 HTRA2 Serine protease HTRA2, mitochondrial 1 32568600.0 7208900.0 6899700.0 18460000.0 True False 6980057.415452351 9654786.191460168 13624772.21187069 1.0 1.3831958129866584 1.9519570400249668 22.734807472900606 -6.965432367843208 0.3505596330134826 0.9453887623677518 2.4089724073926817 0.9999217748717665 0.0034589745577879518 0.07781462460689985 0.014344797358809214 0.007796089574995244 0.048868469779964833 1.082848332664791e-07 6.965432367843208 1.4635836450249298 IQTK(ub)EPLPTLPLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQTKEPLPTLPLGR 14 1 A0A0C4DG44;O43464-3;O43464;O43464-4 A0A0C4DG44 HTRA2 Serine protease HTRA2, mitochondrial 1 45976000.0 12437000.0 16221000.0 17318000.0 True False 18867838.266491417 13326235.81474853 13895089.709250957 1.0 0.7062937272689809 0.7364431215169002 24.169425803585217 -10.030371782555637 5.924127943125518 1.0000005021444909 0.7213684246110916 0.9912951585723275 0.012308438660340681 8.162839891414073e-08 1.3369670761260224e-08 0.011917615974643456 0.003972531495760655 9.3245572008024e-11 10.030371782555637 -0.27863207753339925 IQTK(ub)EPLPTLPLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQTKEPLPTLPLGR 14 1 A0A0C4DG44;O43464-3;O43464;O43464-4 A0A0C4DG44 HTRA2 Serine protease HTRA2, mitochondrial 1 19671100.0 4058300.0 4395800.0 11217000.0 True False 5558763.1814337615 4201579.021033296 8567775.62136654 1.0 0.7558478179222579 1.5413097017665482 22.406332489951836 -6.823210937196827 1.358005702423001 0.8688154971441719 1.559655650180205 0.8915938900014287 0.10806790798459337 0.1893412576627515 0.6852366843618818 0.06252157345072074 0.14398782924546263 1.502412066037864e-07 6.823210937196827 0.6908401530360331 IQTK(ub)EPLPTLPLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQTKEPLPTLPLGR 14 1 A0A0C4DG44;O43464-3;O43464;O43464-4 A0A0C4DG44 HTRA2 Serine protease HTRA2, mitochondrial 1 31165900.0 7208900.0 12815000.0 11142000.0 True False 5994519.758418985 12745963.051421659 13471740.685212687 1.0 2.1262692534327927 2.247342777758359 22.515212748334882 -10.769462169727603 0.4232610065033885 5.624828165360588e-22 2.253185544416966 0.999503958506015 0.012508948344746296 2.3745638988403064 0.2039700477057854 2.4455534670975867 0.02904898074612299 1.7003480601264807e-11 10.769462169727603 2.253185544416966 IQTK(ub)EPLPTLPLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQTKEPLPTLPLGR 14 1 A0A0C4DG44;O43464-3;O43464;O43464-4 A0A0C4DG44 HTRA2 Serine protease HTRA2, mitochondrial 1 35097900.0 12437000.0 19100000.0 3560900.0 True False 16099941.669921394 18037068.20975064 2912852.7379194535 1.0 1.12031885453649 0.1809231857877703 23.940552125677666 -6.87473475536464 1.1087959219705745 1.070438534418518 0.12073425094705366 0.9691819858230437 0.07327068178255164 0.13239361756846293 0.3013713374923996 0.05112404525915743 0.12213225373873182 1.3343361269302893e-07 6.87473475536464 -0.9497042834714644 down IQTLK(ub)SNNSMAQAMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQTLKSNNSMAQAMK 15 1 M0R1L7;M0R1T5;O43633 M0R1L7 CHMP2A Charged multivesicular body protein 2a 1 4323160.0 1270900.0 2204800.0 847460.0 True False 1666162.207413107 1875852.4342430858 759772.9686103383 1.0 1.1258522284907333 0.4560018017633266 20.668097428874535 -6.858122582830496 1.1952371604798433 1.0679674026226271 0.42471638321964716 0.9513128500269948 0.06413980766473873 0.14874697346910465 0.40486889760968964 0.04188607311234314 0.09757390796336599 1.3863644620154466e-07 6.858122582830496 -0.6432510194029799 down IQTLK(ub)SNNSMAQAMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQTLKSNNSMAQAMK 15 1 M0R1L7;M0R1T5;O43633 M0R1L7 CHMP2A Charged multivesicular body protein 2a 1 7214600.0 2880700.0 2252500.0 2081400.0 True False 2789253.7553154565 3151934.996632319 1536218.899338444 1.0 1.1300280552193231 0.5507634063092628 21.4114477603709 -6.847766158508357 1.2458644661476836 1.0692757592798083 0.528590768477953 0.9369856968722918 0.06229574024222933 0.15993144952803348 0.4788346259341249 0.03914866128380234 0.09047025298167871 1.4198218046674562e-07 6.847766158508357 -0.5406849908018553 IQVDAYFSPIHSQLDHLLDPSSFTGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQVDAYFSPIHSQLDHLLDPSSFTGR 26 0 P30566;A0A0A6YY92;A0A1B0GTJ7;A0A1B0GWJ0;A0A096LNY6;A0A096LNT0;A0A096LP76 P30566 ADSL Adenylosuccinate lyase 0 204779000.0 63870000.0 66280000.0 74629000.0 False True 96895459.52245775 54451816.15199634 59878545.438947245 1.0 0.561964579355505 0.6179706018636406 26.529925727396698 -10.157024553424584 5.2590832914113195 1.0000151195929423 0.5899675906097908 0.9862006175235688 0.022864362945385172 4.053475577313764e-06 6.49711874601881e-07 0.022139139954841316 0.007379441408983921 6.965871305040582e-11 10.157024553424584 -0.41004752898315155 IQVDAYFSPIHSQLDHLLDPSSFTGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQVDAYFSPIHSQLDHLLDPSSFTGR 26 0 P30566;A0A0A6YY92;A0A1B0GTJ7;A0A1B0GWJ0;A0A096LNY6;A0A096LNT0;A0A096LP76 P30566 ADSL Adenylosuccinate lyase 0 127388700.0 63870000.0 33894700.0 29624000.0 False True 82680974.06592262 32008430.14916407 24232735.967908666 1.0 0.3871317496047317 0.293087209502244 26.301052049489147 -13.999999999999998 0.26388031345238777 5.578729863632339 0.25997095991309854 0.9995703490060723 0.0064969006980423365 14.592215462608667 0.16257343146217432 35.71153319625349 0.040291624996751325 1.0000000000000041e-14 13.999999999999998 -5.318758903719241 IQVHYYEDGNVQLVSHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQVHYYEDGNVQLVSHK 17 0 P52907;P47755 P52907;P47755 CAPZA1;CAPZA2 F-actin-capping protein subunit alpha-1;F-actin-capping protein subunit alpha-2 0 30351800.0 9131700.0 7301100.0 13919000.0 False True 11971747.131508583 6211804.339464901 12478795.40047591 1.0 0.5188719968128945 1.0423537403018495 23.5131303757269 -6.665086209247961 1.9551373759793875 0.6916005406250726 1.0401816845056828 0.257294092027612 0.20460883378100692 0.4725179548152789 3.4774269596056837 0.08440117696043362 0.22692516444297972 2.1622892577766337e-07 6.665086209247961 0.34858114388061023 IQVHYYEDGNVQLVSHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQVHYYEDGNVQLVSHK 17 0 P52907;P47755 P52907;P47755 CAPZA1;CAPZA2 F-actin-capping protein subunit alpha-1;F-actin-capping protein subunit alpha-2 0 34243800.0 10019000.0 4140800.0 20084000.0 False True 9700952.329123324 5794243.033986738 14823397.892915014 1.0 0.5972860021785474 1.528035329934933 23.20969495096037 -6.789117309022876 1.4999001633594524 0.7746664140295265 1.5376897392858653 0.7984455612490838 0.17110456369787333 0.23666625073989941 1.0518537210744818 0.08979772124207148 0.21037061413659777 1.6251097315578908e-07 6.789117309022876 0.7630233252563388 IQVHYYEDGNVQLVSHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQVHYYEDGNVQLVSHK 17 0 P52907;P47755 P52907;P47755 CAPZA1;CAPZA2 F-actin-capping protein subunit alpha-1;F-actin-capping protein subunit alpha-2 0 42999800.0 5983800.0 26375000.0 10641000.0 False True 9077862.074377354 21668175.181184433 8537801.685884023 1.0 2.386924917304457 0.9405079759894487 23.11392113800057 -6.655730509615039 1.9884071686866338 1.8958737374585055 0.9466118198868602 0.21753193934065218 0.5911300702838341 0.494604064417291 3.754712248270176 0.24058723152685685 0.6548837182324192 2.2093752793318892e-07 6.655730509615039 -0.9492619175716454 IQVHYYEDGNVQLVSHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQVHYYEDGNVQLVSHK 17 0 P52907;P47755 P52907;P47755 CAPZA1;CAPZA2 F-actin-capping protein subunit alpha-1;F-actin-capping protein subunit alpha-2 0 29772000.0 9131700.0 8235300.0 12405000.0 False True 12507936.264913555 7871437.215504694 9475194.48899455 1.0 0.629315424126771 0.7575345994985396 23.57634043724979 -10.375607214814945 5.129684060986393 1.0001921316897322 0.6934250118126318 0.8840264275482419 0.05234525915029238 0.00011509023138474543 1.4008981493999261e-05 0.05071457885802937 0.016894359745154436 4.211073146380516e-11 10.375607214814945 -0.30676711987710037 IQVHYYEDGNVQLVSHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQVHYYEDGNVQLVSHK 17 0 P52907;P47755 P52907;P47755 CAPZA1;CAPZA2 F-actin-capping protein subunit alpha-1;F-actin-capping protein subunit alpha-2 0 20170900.0 10019000.0 5344200.0 4807700.0 False True 8331242.4169567935 5315409.733859352 5812967.841706782 1.0 0.6380092509420636 0.6977312087181016 22.990100226394645 -10.574660466953008 6.391052109852513 1.000635244165472 0.667870229830091 0.9763240327853421 0.0243813871652225 0.0002210879630683633 1.471387433869461e-05 0.02365025733717275 0.007869058870695174 2.662806037934182e-11 10.574660466953008 -0.33276501433538097 IQVHYYEDGNVQLVSHK(ub)DVQDSLTVSNEAQTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQVHYYEDGNVQLVSHKDVQDSLTVSNEAQTAK 33 1 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 1 15238500.0 4462200.0 2401100.0 8375200.0 True False 4320549.903484789 3359871.751571081 6181483.869385666 1.0 0.777649101763907 1.4307169243433389 22.042783514245663 -6.814815593334572 1.394031536315314 0.879488458581938 1.4434633337054137 0.8720639524546474 0.09696728158335156 0.20030830569903574 0.7662104326594712 0.0546780104568891 0.12623842343084576 1.531737717894351e-07 6.814815593334572 0.5639748751234757 IQVHYYEDGNVQLVSHK(ub)DVQDSLTVSNEAQTAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQVHYYEDGNVQLVSHKDVQDSLTVSNEAQTAK 33 1 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 1 49505000.0 13730000.0 17772000.0 18003000.0 True False 20829413.797453325 14600447.746730218 14444699.159004789 1.0 0.7009533676130298 0.6934760286326851 24.312118902370347 IQVHYYEDGNVQLVSHK(ub)DVQDSLTVSNEAQTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQVHYYEDGNVQLVSHKDVQDSLTVSNEAQTAK 33 1 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 1 46579000.0 13730000.0 18703000.0 14146000.0 True False 17773755.658761807 17662161.608741667 11571573.150217235 1.0 0.9937214141927777 0.651048285594771 24.083245224462797 -6.9108711116937505 0.8897844404861579 1.0103197525548604 0.6059287735708758 0.991246108259342 0.015254169433571291 0.10384471588495191 0.13566451241133798 0.01254283455919446 0.03483635275593851 1.2278035600822804e-07 6.9108711116937505 -0.4043909789839846 IQVLQQQADDAEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQVLQQQADDAEER 14 0 P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;Q5VU61 P06753-2 TPM3 Tropomyosin alpha-3 chain 0 48563700.0 1482700.0 30605000.0 16476000.0 False True 1943834.0584872244 26038853.297355596 14771221.568951854 1.0 13.395615322030192 7.599013662949941 20.890473633321385 -9.87321769218231 6.5590508669051735 0.9999996201980087 10.497314492490624 0.781624189630733 2.366452717821509 1.3362323663462876e-05 2.2904207030154757e-06 2.2913079913463936 0.7637693304755359 1.3390053363639685e-10 9.87321769218231 9.497314872292614 IQVLQQQADDAEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQVLQQQADDAEER 14 0 P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;Q5VU61 P06753-2 TPM3 Tropomyosin alpha-3 chain 0 37092500.0 13384000.0 3980500.0 19728000.0 False True 12959132.246031193 5569934.408033278 14560644.97268609 1.0 0.42980766785053076 1.1235817874414677 23.627465781642343 -6.6883114599915094 1.8722307631778452 0.6419663053469477 1.1211488538431527 0.36262065679987954 0.24123379848606422 0.4203060850382509 2.8550420175098288 0.10312356842611338 0.269132239244761 2.049691688283882e-07 6.6883114599915094 0.479182548496205 IQVLQQQADDAEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQVLQQQADDAEER 14 0 P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;Q5VU61 P06753-2 TPM3 Tropomyosin alpha-3 chain 0 46228700.0 1482700.0 20353000.0 24393000.0 False True 2030894.2584608935 19453737.16162944 18631875.789604507 1.0 9.578902043069633 9.174222494343262 20.953683694844276 -10.04841458367397 5.457594698264169 0.9999463366576999 9.376562268712883 0.9982525989789077 0.16520973397585306 0.00010787954921524589 1.881224079930683e-05 0.15996459184535133 0.05332121235670873 8.945104454793348e-11 10.04841458367397 8.376615932055183 IQVSSEK(ub)EAAPDAGAEPITADSDPAYSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQVSSEKEAAPDAGAEPITADSDPAYSSK 29 1 Q8N163;Q8N163-2;E5RHJ4 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 1 10388300.0 3225600.0 2010900.0 5151800.0 True False 4228792.836754834 1710881.5584268083 4618741.155555123 1.0 0.40457918476321836 1.092212679564491 22.011814455605514 -6.677701110393448 1.9101378118465713 0.6224963435960307 1.0895462964458147 0.31362426673304944 0.25248105813639876 0.44363460621343137 3.12750771531377 0.10614250731604732 0.2807624282658766 2.1003849106020948e-07 6.677701110393448 0.467049952849784 IQVSSEK(ub)EAAPDAGAEPITADSDPAYSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQVSSEKEAAPDAGAEPITADSDPAYSSK 29 1 Q8N163;Q8N163-2;E5RHJ4 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 1 11011600.0 3225600.0 4103900.0 3682100.0 True False 4418191.488562392 3922576.1282175127 2812463.8152298955 1.0 0.8878239294000938 0.6365644908127388 22.075024517128405 -6.957771066226299 0.46579027918408616 1.0069152935282386 0.5072455167253345 0.9996783700413313 0.0027250780283972586 0.08050723947869161 0.024148138670062273 0.0034472185372046256 0.020744733659701052 1.1021201274889256e-07 6.957771066226299 -0.49966977680290414 IQVTPPGFQLVFLPFADDKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQVTPPGFQLVFLPFADDKR 20 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 857130000.0 351890000.0 205540000.0 299700000.0 False True 340719444.5648473 287613193.8769398 221199579.19272196 1.0 0.8441349575580207 0.6492132536645476 28.344009042244323 -6.968102838458568 0.3000600104430229 1.0337818441008435 0.4534581194637725 0.999963571836818 0.0008661078777434369 0.07692320586157911 0.011221756254884922 0.0032328479774195455 0.017480541720724732 1.076210342978434e-07 6.968102838458568 -0.5803237246370709 IQVTPPGFQLVFLPFADDKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQVTPPGFQLVFLPFADDKR 20 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 1897960000.0 732540000.0 510760000.0 654660000.0 False True 1111316735.8475208 419610887.4139059 525266164.05232936 1.0 0.37757992287761155 0.47265207758411637 30.04962291113837 -10.795597566540206 7.226249943298038 1.0191653673640935 0.425116000230864 0.9799003082104695 0.0388130446296465 0.011240465961938438 0.00031794852212557555 0.03524828241761811 0.012526856288852166 1.6010409256719586e-11 10.795597566540206 -0.5940493671332294 IQVTPPGFQLVFLPFADDKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQVTPPGFQLVFLPFADDKR 20 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 137247000.0 76254000.0 13318000.0 47675000.0 False True 104447164.4868666 12729566.723263446 36415146.897445835 1.0 0.1218756563263533 0.34864658199528964 26.638198086005946 -10.140579982003178 5.552531091468432 1.0000129287578805 0.23526111946948378 0.9381309920897318 0.09257884273165728 1.4817323908902205e-05 2.2933522186149294e-06 0.08964059124073394 0.0298796930091797 7.234691520478018e-11 10.140579982003178 -0.7647518092883967 IQVTPPGFQLVFLPFADDKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQVTPPGFQLVFLPFADDKR 20 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 820400000.0 351890000.0 162750000.0 305760000.0 False True 292612126.3701891 161873233.4466544 369693002.32549196 1.0 0.553200701060029 1.2634233820432528 28.1244143176786 -6.736661584322847 1.6990203360877116 0.7331333005118009 1.2635363215608928 0.5898339226513636 0.18774626113341894 0.3238827932869783 1.834446331000173 0.08746800079703296 0.21542181173676744 1.8337427748115337e-07 6.736661584322847 0.5304030210490919 IQVTPPGFQLVFLPFADDKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQVTPPGFQLVFLPFADDKR 20 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 1659150000.0 732540000.0 595490000.0 331120000.0 False True 948287470.5221688 562350458.0222197 270859557.5781092 1.0 0.5930168598690487 0.2856302186814321 29.82074923323082 -7.92809900065106 0.24755347772148337 1.172888893217658 2.2508743323584215e-09 0.999664313423495 0.00536063929547439 0.10953068278984616 0.04214788481155582 0.06082784199439025 0.09284870885551035 1.1800516034660329e-08 7.92809900065106 -1.1728888909667836 down IQVWHAEHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQVWHAEHR 9 0 P15311;E7EQR4 P15311 EZR Ezrin 0 8145300.0 1531800.0 3999500.0 2614000.0 False True 2008204.6339723023 3402790.189928892 2343528.35525857 1.0 1.6944439487713203 1.1669768685987867 20.937474855233873 -10.006723995262014 5.91242100449165 0.9999994226016012 1.4307104086851212 0.4706291216337207 0.21533753375664236 1.6390280690420988e-06 2.7535475946428866e-07 0.2084999501201035 0.06949989017103601 9.846366675829176e-11 10.006723995262014 0.43071098608352 IQVWHAEHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQVWHAEHR 9 0 P15311;E7EQR4 P15311 EZR Ezrin 0 6179200.0 1881400.0 1002100.0 3295700.0 False True 1821675.986826291 1402243.7558824625 2432457.301119298 1.0 0.7697547566213683 1.3352853738589954 20.79683494571539 -6.7961765261068985 1.4714365050724887 0.8723366452956768 1.3423764788097705 0.8207290785189796 0.09831465213057769 0.2262790489965585 0.9675697741727202 0.05257282410574834 0.1225626763081184 1.5989079941670736e-07 6.7961765261068985 0.47003983351409373 IQVWHAEHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IQVWHAEHR 9 0 P15311;E7EQR4 P15311 EZR Ezrin 0 13663990.0 1037300.0 11742000.0 884690.0 False True 1573659.9367879324 9646548.359335274 709830.6337265982 1.0 6.130008227206492 0.45106990216416465 20.585692381760914 -6.668778743203416 1.9417057145792114 4.277922731040862 0.4741756817793271 0.2736152589154759 2.1797372033315536 0.4639501853217666 3.3711054652112886 0.9041242447322926 2.41944354290934 2.1439826018836732e-07 6.668778743203416 -3.803747049261535 IQVWHAEHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQVWHAEHR 9 0 P15311;E7EQR4 P15311 EZR Ezrin 0 6503100.0 1531800.0 2001500.0 2969800.0 False True 2098147.8553385036 1913067.1119245947 2268394.404950908 1.0 0.9117885124525464 1.0811413500622613 21.000684916756764 -6.765156313289359 1.593045100172871 0.9490920404653723 1.0819233875413212 0.7116807561565057 0.037134688250073565 0.2743309129301562 1.3731694521888342 0.018382678969437957 0.043954821082349806 1.7172901808432737e-07 6.765156313289359 0.1328313470759489 IQVWHAEHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQVWHAEHR 9 0 P15311;E7EQR4 P15311 EZR Ezrin 0 4278550.0 1881400.0 1534700.0 862450.0 False True 1564467.4601519613 1526432.2664859022 1042784.3074817525 1.0 0.975688088992043 0.6665426632654052 20.577240221149665 -6.922575469446976 0.8053997080694822 1.0062088883135143 0.6136131309512539 0.9948668238262139 0.010875013877527828 0.09668009009502367 0.09793647877718391 0.009500052427403106 0.029197032302156273 1.1951558196354904e-07 6.922575469446976 -0.3925957573622604 IQVWHAEHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IQVWHAEHR 9 0 P15311;E7EQR4 P15311 EZR Ezrin 0 4726400.0 1037300.0 1821800.0 1867300.0 False True 1342805.298239884 1720415.2285090932 1527470.5601159816 1.0 1.2812097411025791 1.137521993782831 20.356818703853364 -10.195252081857152 4.0798436403780185 0.9998910363857089 1.2093658674626597 0.7389587341576735 0.05866027729849018 41217710.58808452 8.521603201848208 42228.293572477225 0.020080973177388987 6.378931200775793e-11 10.195252081857152 0.20947483107695086 IQVWHEEHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQVWHEEHR 9 0 P26038 P26038 MSN Moesin 0 6042150.0 903950.0 2537000.0 2601200.0 False True 1185087.2038642534 2158489.489148547 2332052.776472299 1.0 1.821376082798201 1.9678322142607705 20.17656179212165 -10.999307259833307 0.3224538372685264 1.4024028392514978e-12 2.002063967447687 0.9992911531282127 0.01134024309301373 2.855540621681484 0.16307968414977012 2.168887487599611 0.04812606743179568 1.0015963660189491e-11 10.999307259833307 2.0020639674462846 IQVWHEEHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQVWHEEHR 9 0 P26038 P26038 MSN Moesin 0 4852550.0 903950.0 0.0 3948600.0 False True 1238164.7433302263 0.0 3016022.0039696814 1.0 0.0 2.435881024893058 20.23977185364454 -6.795230805905851 1.4753473069178114 0.44487829593314887 2.4656678533522247 0.817849540686524 0.42667873507559345 0.2276296850325617 0.9786045000613263 0.227575554188207 0.5308581954832989 1.6023935719149822e-07 6.795230805905851 2.020789557419076 IQVYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQVYSR 6 0 P61769;F5H6I0 P61769 B2M Beta-2-microglobulin;Beta-2-microglobulin form pI 5.3 0 7964000.0 1196200.0 3354700.0 3413100.0 False True 1568229.7840172767 2854191.8365181787 3059945.1527670287 1.0 1.8200086910775921 1.951209691304599 20.580705534372946 -11.03200750558723 0.338455563156612 2.186121515580226e-15 1.9766555420928342 0.9993440033199298 0.01078032706720181 2.90082166998695 0.17021614200298665 2.290035447168007 0.04063794019518932 9.289503322862881e-12 11.03200750558723 1.976655542092832 IQVYSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQVYSR 6 0 P61769;F5H6I0 P61769 B2M Beta-2-microglobulin;Beta-2-microglobulin form pI 5.3 0 9025900.0 1196200.0 3685400.0 4144300.0 False True 1638467.4660895115 3522566.8420119425 3165501.6945376936 1.0 2.1499156467349105 1.9319893498359877 20.643915595895837 -10.143671624370233 4.351745599057546 0.9998065296335455 2.04095249834431 0.9681747038712581 0.0889680383624222 6593358.0029183375 7684397.89075496 9948.455387532656 0.03045612539715305 7.183372299798903e-11 10.143671624370233 1.0411459687107647 IQYAK(ub)TDSDIISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQYAKTDSDIISK 13 1 P08579 P08579 SNRPB2 U2 small nuclear ribonucleoprotein B 1 10438400.0 4445000.0 3580800.0 2412600.0 True False 5827438.045441234 3046558.5978490775 2162967.29529335 1.0 0.5227955362360961 0.37116950509416824 22.474430330710092 -13.999999999999998 0.1604440620071432 3.3523841890782 0.22284155522447266 0.999535206238314 0.0057766063778405185 12.012663859341579 0.12659602958596544 8.793624866301927 0.13526325929391064 1.0000000000000041e-14 13.999999999999998 -3.1295426338537276 IQYAK(ub)TDSDIISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQYAKTDSDIISK 13 1 P08579 P08579 SNRPB2 U2 small nuclear ribonucleoprotein B 1 15965600.0 5849400.0 4559600.0 5556600.0 True False 5663713.998799683 6380272.057999879 4101159.7655731677 1.0 1.1265173452176536 0.7241113810553166 22.43331698465132 -6.822210735012344 1.3624655056147534 1.0680421140325347 0.7149159214621396 0.8893554390577646 0.05588623534720577 0.19062404420922985 0.6947287503833214 0.032229791270319184 0.07423754057820839 1.5058761845971315e-07 6.822210735012344 -0.3531261925703951 IQYAK(ub)TDSDIISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQYAKTDSDIISK 13 1 P08579 P08579 SNRPB2 U2 small nuclear ribonucleoprotein B 1 16680400.0 5849400.0 7630900.0 3200100.0 True False 4864035.272357232 7589790.827084938 3869226.1144093624 1.0 1.560389759140611 0.7954765740286747 22.213722260085596 -6.710351249175522 1.7941868952621012 1.3443940455949595 0.7972725442839907 0.46668761678642934 0.23613200729551426 0.3743576102388695 2.349401055940731 0.10473074879456759 0.2659287449251803 1.9482682398186365e-07 6.710351249175522 -0.5471215013109687 IQYLVYQMLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQYLVYQMLK 10 0 O15264;O15264-2;Q5R3E6 O15264 MAPK13 Mitogen-activated protein kinase 13 0 6549900.0 1806400.0 2859600.0 1883900.0 False True 2368207.893202485 2432958.826633496 1688972.0996448426 1.0 1.027341743778858 0.7131857403620405 21.1753643028786 -6.885703645978998 1.0474298694323334 1.0186590383509446 0.6883314248208129 0.9780041838276055 0.021073224606206094 0.12269973396042028 0.24274781582192193 0.015409139657957307 0.037867823330199314 1.3010570909825796e-07 6.885703645978998 -0.33032761353013174 IQYLVYQMLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQYLVYQMLK 10 0 O15264;O15264-2;Q5R3E6 O15264 MAPK13 Mitogen-activated protein kinase 13 0 4721400.0 3169400.0 0.0 1552000.0 False True 3068789.131841852 0.0 1145484.640998014 1.0 0.0 0.37326925760796975 21.549238085477935 -10.629829395212722 6.512441984948078 1.00315915613289 0.18663462880399653 0.8635911531311566 0.15238653630116894 0.007001169839914468 0.0003979497254215459 0.14778809786850663 0.049182543106721585 2.345149884408503e-11 10.629829395212722 -0.8165245273288936 IQYLVYQMLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQYLVYQMLK 10 0 O15264;O15264-2;Q5R3E6 O15264 MAPK13 Mitogen-activated protein kinase 13 0 8620600.0 1806400.0 2562100.0 4252100.0 False True 2474274.896124476 2448897.950268301 3247841.554748387 1.0 0.989743683737032 1.3126437809459124 21.23857436440149 -6.8995661216671555 0.9640341969419121 0.9864146583488966 1.3462372319195832 0.9863483806913786 0.017509386823333542 0.11172450129855593 0.17923864020417038 0.013633484340247871 0.035394353791931496 1.26018375934642e-07 6.8995661216671555 0.3598225735706866 IQYLVYQMLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IQYLVYQMLK 10 0 O15264;O15264-2;Q5R3E6 O15264 MAPK13 Mitogen-activated protein kinase 13 0 7383000.0 3169400.0 2586300.0 1627300.0 False True 2635496.5282266596 2572367.088559643 1967560.9062149178 1.0 0.9760464720818682 0.7465617522701978 21.32964336091221 -6.926904810033945 0.7717735708089933 1.0039193858366016 0.7029596667737262 0.9958941987952142 0.007320441443856404 0.09427716602621984 0.08578877135100386 0.006550345901485162 0.02112881974916119 1.1833008867381713e-07 6.926904810033945 -0.30095971906287533 IQYQLVDISQDNALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IQYQLVDISQDNALR 15 0 Q5T123;Q9H299 Q5T123 SH3BGRL3 SH3 domain-binding glutamic acid-rich-like protein 3 0 16920600.0 2453100.0 8218600.0 6248900.0 False True 3216037.8558541886 6992416.915851887 5602323.771681438 1.0 2.174233398131031 1.7419955929571749 21.616852957847133 -10.108355404027053 4.919937641397021 0.999960682908135 1.9581144955488958 0.867572622217951 0.17646034505265132 23544761.130718272 48374361.84032085 6581.945459027186 0.060407070491569896 7.791921991528744e-11 10.108355404027053 0.9581538126407608 IQYQLVDISQDNALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IQYQLVDISQDNALR 15 0 Q5T123;Q9H299 Q5T123 SH3BGRL3 SH3 domain-binding glutamic acid-rich-like protein 3 0 15198500.0 3308900.0 1151600.0 10738000.0 False True 3203860.7807002845 1611439.8855146663 7925395.666905066 1.0 0.5029681362004892 2.4737016397987093 21.61138002813288 -6.839864714773771 1.2829489526031383 0.73558169482127 2.5383781876888163 0.9242357900182809 0.23034119889502172 0.16895413135825296 0.5402424328291048 0.14078367860466648 0.3243400041218919 1.4458901036758856e-07 6.839864714773771 1.8027964928675462 up IQYQLVDISQDNALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IQYQLVDISQDNALR 15 0 Q5T123;Q9H299 Q5T123 SH3BGRL3 SH3 domain-binding glutamic acid-rich-like protein 3 0 16768800.0 2453100.0 6765200.0 7550500.0 False True 3360077.362534844 6466291.094475291 5767227.407428728 1.0 1.9244470876102442 1.716397209104117 21.680063019370024 -10.195737167697477 4.639538279081424 0.9998477247997641 1.8204221483635459 0.953988682532688 0.08493600725310968 59683221.603457354 27.301992616065196 97089.55285576844 0.029075854444829734 6.371810222116642e-11 10.195737167697477 0.8205744235637817 IRELTAVVQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IRELTAVVQKR 11 2 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 17228400.0 1295600.0 1557800.0 14375000.0 True False 1677179.7400940873 1471107.0605837451 11758897.499955656 1.0 0.8771314280848743 7.011113489420042 20.67760587733616 -6.902330306513702 0.946417347407432 0.761020439215198 7.686339989103411 0.9876904532746739 0.3176525730035837 0.10971029043609415 0.1679032888601636 0.25058285021088805 0.6599377289088402 1.2521884496725352e-07 6.902330306513702 6.925319549888213 up IRFPILGLGSSSGTNTSSPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IRFPILGLGSSSGTNTSSPR 20 1 H3BQ92;Q8IVW6-3;Q8IVW6-4;Q8IVW6 H3BQ92 ARID3B AT-rich interactive domain-containing protein 3B 0 5768000.0 1492100.0 2514500.0 1761400.0 False True 2043769.69248634 2403401.075660453 1345393.5971717066 1.0 1.1759647305155039 0.6582902183733693 20.962801200908846 -6.815014107566378 1.3936017473236841 1.0953464566191315 0.6481791350044286 0.8724557038595158 0.07675517516431452 0.2000458565748879 0.7647543994243464 0.04329783646395693 0.09993719813458136 1.5310377268406377e-07 6.815014107566378 -0.44716732161470296 IRPEAENK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IRPEAENKSR 10 2 Q8IY92-2;Q8IY92 Q8IY92-2 SLX4 Structure-specific endonuclease subunit SLX4 1 4745200.0 1741400.0 1887800.0 1116000.0 True False 1686120.2101941686 2641608.3847469487 823686.1207176433 1.0 1.566678561099003 0.4885097253076576 20.685275964719654 -6.763880983342275 1.5977188306868373 1.3275653246021024 0.4837775416470276 0.7066585215685035 0.23849949011200655 0.2764473887387501 1.3916256708115526 0.11772887892488486 0.2818638010015823 1.7223405108134407e-07 6.763880983342275 -0.8437877829550748 down IRPEAENK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IRPEAENKSR 10 2 Q8IY92-2;Q8IY92 Q8IY92-2 SLX4 Structure-specific endonuclease subunit SLX4 1 3520350.0 1741400.0 955620.0 823330.0 True False 1448051.2571003668 950471.8853842813 995484.4963521941 1.0 0.6563800008623607 0.6874649577982415 20.46568124015393 -9.912492617238161 5.6283887161937765 1.000000248348798 0.671922479692749 0.9933120250452098 0.01269038053052102 3.954711795077622e-08 7.644777132141094e-09 0.012287417358183885 0.004095802703976717 1.2232279130594667e-10 9.912492617238161 -0.328077768656049 IRPFAVAAVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IRPFAVAAVLR 11 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 23861000.0 6831600.0 10318000.0 6711400.0 False True 8956293.757308504 8778594.619248992 6016968.708294696 1.0 0.9801592999431817 0.6718145776967998 23.0944704172179 -6.919999750344471 0.824741999107823 1.00680354450463 0.6220937073335232 0.994180552722548 0.011461871644808717 0.09817190811252202 0.10561947962717748 0.009875543048249944 0.02958127543431381 1.2022651257430487e-07 6.919999750344471 -0.38470983717110674 IRPFAVAAVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IRPFAVAAVLR 11 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 15121800.0 8171700.0 4063400.0 2886700.0 False True 7912293.85646244 5685936.810351062 2130586.670856294 1.0 0.7186205307209387 0.2692754730179943 22.91566457699204 -7.08971608831534 0.39943518118980564 1.0270848882911667 3.995274196012839e-15 0.9998318087639777 0.0039027470508855022 0.0754402621319417 0.01931085330250671 0.0065271379724812 0.03663899819119696 8.133620622432148e-08 7.08971608831534 -1.0270848882911627 down IRPFAVAAVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IRPFAVAAVLR 11 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 67298000.0 14651000.0 20729000.0 31918000.0 False True 22226638.131572347 17029747.993583784 25609393.309843633 1.0 0.7661864062740771 1.1521937397030895 24.405786415649196 -6.7427183581905865 1.6766356555699464 0.8613217556662576 1.152561530169517 0.6171158771411291 0.09823492495512662 0.31292664501722656 1.7282222297706733 0.046330682030964146 0.11335861324481968 1.8083464661721518e-07 6.7427183581905865 0.29123977450325933 IRPFAVAAVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IRPFAVAAVLR 11 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 26766300.0 6831600.0 7916700.0 12018000.0 False True 9357427.137048246 7566914.016973995 9179595.91847936 1.0 0.8086532661328251 0.9809957143171535 23.15768047874079 -10.335837918652015 6.835608615578999 1.000003033629783 0.894824490240903 0.3318069218145171 0.07035850984560897 3.252912692698799e-06 3.160398715728972e-07 0.06812629941602948 0.02270811140800118 4.614897732220661e-11 10.335837918652015 -0.10517854338887989 IRPFAVAAVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IRPFAVAAVLR 11 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 20249300.0 8171700.0 4673500.0 7404100.0 False True 6795130.61769098 4648322.9278828865 8952263.077309573 1.0 0.6840667515324982 1.3174526850157293 22.696069852426316 -6.771064613765622 1.5702266585952103 0.8190390317739162 1.3211736096269895 0.7346895964907065 0.1331896093915172 0.26470090163692656 1.2881492851347622 0.06685090068310456 0.1589878413852002 1.6940857378342275e-07 6.771064613765622 0.5021345778530732 IRPFAVAAVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IRPFAVAAVLR 11 1 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 73446000.0 14651000.0 34731000.0 24064000.0 False True 18966008.31438594 32798189.318997335 19684598.917491004 1.0 1.72931429615158 1.0378883416686053 24.176912737741645 -10.284843906485674 5.0717717321970595 0.999909474354094 1.383601318910209 0.29098138259050477 0.2822734639004234 0.00028900507549094347 4.075140780602229e-05 0.2733742927250614 0.09110336873016042 5.189865388259755e-11 10.284843906485674 0.38369184455611494 IRVDFSITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IRVDFSITK 9 1 P62995-3;P62995;H7BXF3;H7C2L4 P62995-3 TRA2B Transformer-2 protein homolog beta 0 52185400.0 5591400.0 13913000.0 32681000.0 False True 7658691.681903453 13298277.65586156 24962420.886322513 1.0 1.736364147845742 3.259358376484282 22.868666529980963 -6.959383047850712 0.44404261168678183 0.9477834376595866 4.107718834499087 0.9997466305450503 0.014975733099351709 0.0799222421834791 0.02195115199702836 0.02018511477442002 0.12609729618376345 1.0980369433304864e-07 6.959383047850712 3.1599353968395003 IRVDFSITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IRVDFSITK 9 1 P62995-3;P62995;H7BXF3;H7C2L4 P62995-3 TRA2B Transformer-2 protein homolog beta 0 52835000.0 27210000.0 11839000.0 13786000.0 False True 22626320.6073854 11775220.957142482 16668588.860737935 1.0 0.5204213783348832 0.7366902091583191 24.431498663175308 -10.320819412120574 5.78406863784543 1.0000437992275084 0.6285557937465999 0.7972888478209147 0.0882913804642918 4.987362554226819e-05 5.8561638300016215e-06 0.08549781296605213 0.02849592051265458 4.77727880672642e-11 10.320819412120574 -0.37148800548090855 IRVDFSITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IRVDFSITK 9 1 P62995-3;P62995;H7BXF3;H7C2L4 P62995-3 TRA2B Transformer-2 protein homolog beta 0 570330000.0 135270000.0 232850000.0 202210000.0 False True 175109681.5703355 219891692.80839983 165409854.8498112 1.0 1.2557369234897324 0.9446071363185694 27.38368360967437 -6.688283339996225 1.8722978264766517 1.160584869326859 0.9456973154248632 0.36251697043167863 0.1081962048347812 0.42035958860823774 2.85557952959063 0.04625054828012423 0.12071059036509167 2.049824407415764e-07 6.688283339996225 -0.21488755390199576 IRVDVADQAQDKDRDDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IRVDVADQAQDKDRDDR 17 3 E7EX17;P23588-2;P23588;F8VP89;F8W0K0;F8VSC7 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 3871980.0 822280.0 1615800.0 1433900.0 False True 1126299.137281462 1544408.6132639349 1095242.3520974843 1.0 1.3712241820513684 0.9724258110869735 20.10315861748587 -6.66220441656305 1.9645074115016892 1.2385042226196594 0.9740600584860036 0.2453161430322477 0.15797322384220966 0.47919593775877595 3.5572184771902555 0.06490711937210285 0.1752295263383497 2.1766849948886287e-07 6.66220441656305 -0.2644441641336558 IRVDYSITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IRVDYSITK 9 1 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 0 26640700.0 5423400.0 10453200.0 10764100.0 False True 7110129.920280316 8893623.306254467 9650334.188538156 1.0 1.2508383680707535 1.3572655207062228 22.761444491142374 -13.262681536517348 0.12444972062267971 4.396584845221996e-20 1.5233832694321663 0.99968892244404 0.0026415836781468007 9.261285919045795 0.10234868222767819 2.390144131272161 0.14092324208663676 5.461582062400968e-14 13.262681536517348 1.5233832694321663 IRVDYSITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IRVDYSITK 9 1 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 0 22417000.0 10755800.0 2806800.0 8854400.0 False True 10414363.016427264 3927569.8772686385 6535167.013693825 1.0 0.3771301107012904 0.6275148084799305 23.312071265362064 -10.311554311635268 5.736569859163324 1.0000559282533519 0.5023224595906362 0.8404512903761245 0.10221912482645196 7.312514471229482e-05 8.775429532796145e-06 0.09898431099113904 0.03299108067639383 4.8802906590137176e-11 10.311554311635268 -0.49773346866271573 IRVDYSITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IRVDYSITK 9 1 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 0 16215500.0 5423400.0 5011700.0 5780400.0 False True 7428577.541874163 4790266.522524352 4415188.571074893 1.0 0.64484303966972 0.5943518185260782 22.824654552665265 -13.9999999999993 0.2747879635316803 3.8130812550994913 0.578354546551561 0.9995937097513036 0.0036383564671403166 15.123405205990279 0.1659892705739613 23.834374045963518 0.020480291327154607 1.0000000000016115e-14 13.9999999999993 -3.2347267085479303 IRVDYSITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IRVDYSITK 9 1 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 0 17294300.0 10755800.0 5418400.0 1120100.0 False True 8943924.262731208 5389210.00373181 1354307.7312427512 1.0 0.6025554158802889 0.15142209297165785 23.09247654079634 -7.61095562845553 0.4287158123762667 1.032835768619334 7.068193710780266e-27 0.998067190965388 0.015240530686069793 0.11973797123904825 0.06360033766892029 0.02408516224267548 0.07235962824556047 2.4493134735989214e-08 7.61095562845553 -1.032835768619334 down IRVDYSITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IRVDYSITK 9 1 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 0 39935600.0 8155000.0 22053500.0 9727100.0 False True 10556808.259082472 20826203.338415477 7956867.608474358 1.0 1.972774614003035 0.7537190610266816 23.33167038102758 -6.694183687382973 1.8518694259118949 1.60746615819109 0.7577422817078334 0.38997133171444953 0.41107266160800465 0.40771531351927204 2.7141281944048017 0.17738098981992434 0.45943711652026514 2.0221637118479354e-07 6.694183687382973 -0.8497238764832566 ISAEDGLK(ub)HEYFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISAEDGLKHEYFR 13 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-8;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 36997500.0 4080700.0 8192800.0 24724000.0 True False 6190720.239130941 6730730.829361435 19837290.563085828 1.0 1.087229041108519 3.2043590724220166 22.56167583417173 -6.915565877935987 0.8569585216024521 0.9454145801385029 3.513229799331193 0.9928581375308523 0.08613272085483643 0.10085166887801202 0.11964999065324237 0.07251941883381505 0.20882057586050612 1.2146023640065785e-07 6.915565877935987 2.56781521919269 up ISAEDGLK(ub)HEYFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISAEDGLKHEYFR 13 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-8;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 102038700.0 4080700.0 10342000.0 87616000.0 True False 5282546.592622677 9766458.60865135 71670787.01607764 1.0 1.8488163686602717 13.567468977210583 22.33280215626418 -6.9214701364386615 0.8137397615797208 0.7548786772530711 15.522679874273576 0.9945797840388263 0.4222061174767821 0.0973147111427109 0.10118571834158806 0.3666338760113662 1.1141796095552454 1.198201512756621e-07 6.9214701364386615 14.767801197020505 up ISAIPPK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISAIPPK 7 0 F8VYZ5;C9K080;Q6UXM1-2;Q6UXM1 F8VYZ5 LRIG3 Leucine-rich repeats and immunoglobulin-like domains protein 3 1 22338300.0 4726200.0 14867000.0 2745100.0 True False 6196093.968585899 12648901.551112115 2461063.3848585673 1.0 2.0414315236731158 0.39719594269165714 22.56292759321035 -6.7355506802969805 1.7029848610758571 1.6228242932245585 0.39714016551807835 0.5847899615102674 0.4376362149964977 0.32593543672516323 1.8542198780229655 0.20344660255718444 0.501699026633533 1.8384394033793622e-07 6.7355506802969805 -1.22568412770648 ISAIPPK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISAIPPK 7 0 F8VYZ5;C9K080;Q6UXM1-2;Q6UXM1 F8VYZ5 LRIG3 Leucine-rich repeats and immunoglobulin-like domains protein 3 1 30866500.0 4726200.0 20520000.0 5620300.0 True False 6473603.860752591 19613358.549434267 4292900.893711893 1.0 3.0297433966177394 0.6631392630831786 22.626137654733242 -6.679651881123503 1.9029504943021607 2.284616294365098 0.67212858761014 0.32263976725372057 0.8603139699372329 0.4392779980008558 3.0751581375574126 0.36279160705380725 0.9573263607877813 2.0909715263091853e-07 6.679651881123503 -1.612487706754958 ISALALLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISALALLK 8 0 Q92905 Q92905 COPS5 COP9 signalosome complex subunit 5 0 5496800.0 1407400.0 2051700.0 2037700.0 False True 1845115.0292809869 1745594.3574639629 1826858.3509986184 1.0 0.9460626192743085 0.9901053983124929 20.815279329783387 -10.379687042233043 5.452218918152663 1.000013241150942 0.9680840087934044 0.41182488303551823 0.017980389249617815 2.89521767271949e-06 3.293893938035247e-07 0.017416659550205087 0.005803145676841196 4.17169892766478e-11 10.379687042233043 -0.03192923235753753 ISALALLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISALALLK 8 0 Q92905 Q92905 COPS5 COP9 signalosome complex subunit 5 0 3700900.0 1407400.0 1183900.0 1109600.0 False True 1927753.8135549072 1131591.3833662397 847535.3329293315 1.0 0.5869999454336492 0.4396491538338184 20.878489391306278 -13.999999999999998 0.14352894185451637 2.979843044469592 0.26482126098983116 0.9995892470570248 0.004806863013025127 11.939243646918378 0.11894289666128542 6.6084068810765535 0.15669375787830234 1.0000000000000041e-14 13.999999999999998 -2.7150217834797608 ISAMGK(ub)ALVDQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISAMGKALVDQR 12 1 H3BUK6;A0A0B4J294;H3BP13;Q9UL33-2;Q9UL33;H3BPN3;A0A0B4J286 H3BUK6 TRAPPC2L Trafficking protein particle complex subunit 2-like protein 1 4250600.0 1183800.0 1926800.0 1140000.0 True False 1551973.2639355077 1639328.9506075752 1022043.7356521675 1.0 1.056286850232555 0.6585446794749928 20.565672273550312 -6.871044800918276 1.128493525797048 1.0320472567798715 0.6347775676272183 0.9657179144637227 0.03253887653549848 0.1358601268658284 0.32272190350580054 0.02236207022912455 0.05304370830045628 1.3457215250531436e-07 6.871044800918276 -0.39726968915265326 ISAMGK(ub)ALVDQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISAMGKALVDQR 12 1 H3BUK6;A0A0B4J294;H3BP13;Q9UL33-2;Q9UL33;H3BPN3;A0A0B4J286 H3BUK6 TRAPPC2L Trafficking protein particle complex subunit 2-like protein 1 5848200.0 1707000.0 2154600.0 1986600.0 True False 1652812.219364559 3014943.0160905654 1466249.863277482 1.0 1.824129190701223 0.887124287985478 20.65649139463173 -6.674471544084409 1.9217681789222896 1.5240174029869482 0.8908523246635638 0.29885924590689783 0.34971837953460305 0.4509537680551871 3.2150350348823724 0.14629052931146158 0.38855196645261975 2.1160623296882018e-07 6.674471544084409 -0.6331650783233844 ISAMGK(ub)ALVDQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISAMGKALVDQR 12 1 H3BUK6;A0A0B4J294;H3BP13;Q9UL33-2;Q9UL33;H3BPN3;A0A0B4J286 H3BUK6 TRAPPC2L Trafficking protein particle complex subunit 2-like protein 1 4564000.0 1183800.0 1238600.0 2141600.0 True False 1621482.8509921136 1183874.5564975291 1635798.1876364972 1.0 0.7301184565554725 1.0088285464355202 20.628882335073204 -10.994702939325615 10.72986949158127 1.1145148788822092 0.8694735014954963 0.2262672538646897 0.1137829177285591 0.06576781129831702 3.2467859836055816e-05 0.023245628175428808 0.03672327878713317 1.0122716188696859e-11 10.994702939325615 -0.24504137738671294 ISAMGK(ub)ALVDQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISAMGKALVDQR 12 1 H3BUK6;A0A0B4J294;H3BP13;Q9UL33-2;Q9UL33;H3BPN3;A0A0B4J286 H3BUK6 TRAPPC2L Trafficking protein particle complex subunit 2-like protein 1 6003700.0 1707000.0 2657800.0 1638900.0 True False 1419446.132921973 2643481.903868006 1981586.412582578 1.0 1.8623333725432174 1.3960279059716214 20.436896670066005 -10.38461843207012 5.238148945789573 0.9996238898634167 1.629180639257443 0.7082370131179008 0.19036840956189102 0.0008366426021085636 9.828896500843676e-05 0.18442975975564416 0.06144113998975442 4.124597440401217e-11 10.38461843207012 0.6295567493940264 ISAPNVDFNLEGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISAPNVDFNLEGPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 49791000.0 12708000.0 20174000.0 16909000.0 False True 16450756.512129987 19051299.16562873 13831735.500991346 1.0 1.1580804294064673 0.8407963178345323 23.971650594141824 -6.77124503319575 1.5696570741884466 1.090528978220912 0.8389268859316071 0.7352713506962698 0.06664599826071989 0.264442718340935 1.2860036535212422 0.03346328280059863 0.07956687041835556 1.6933821081140515e-07 6.77124503319575 -0.25160209228930486 ISASLQSQSPEHLLPVLIQAAQLCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISASLQSQSPEHLLPVLIQAAQLCR 25 0 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 0 86766000.0 26503000.0 31995000.0 28268000.0 False True 40206988.62883505 26285242.27192404 22680817.409695435 1.0 0.653748096246959 0.5641013710096543 25.260942951284008 -13.999999999999998 0.18971725122906985 2.8543088794056324 0.49960464951234057 0.9994895647926455 0.004246366791947599 12.34613611826512 0.13812648440944011 8.46226996980806 0.061790174971269214 1.0000000000000041e-14 13.999999999999998 -2.354704229893292 ISASLQSQSPEHLLPVLIQAAQLCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISASLQSQSPEHLLPVLIQAAQLCR 25 0 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 0 59490000.0 26503000.0 20342000.0 12645000.0 False True 34308655.95223337 19209949.817944877 10343739.748656651 1.0 0.5599155456480183 0.3014906722973306 25.032069273376457 -8.846466977376258 0.1911184170842009 1.3870176371347598 2.519070502118762e-10 0.99967615188911 0.005189293356325622 0.3547439648952885 0.05820017030728641 0.22386863903733162 0.14007891211798426 1.4240755255315863e-09 8.846466977376258 -1.3870176368828528 down ISATSIFFESMPYK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ISATSIFFESMPYK 14 0 P34897;P34897-3;P34897-2;G3V2Y4;G3V5L0;G3V4W5;G3V540;G3V2D2;P34896-2;P34896;P34896-3;P34896-4 P34897;P34896-2 SHMT2;SHMT1 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase;Serine hydroxymethyltransferase, cytosolic 0 46286800.0 11625900.0 21276400.0 13384500.0 False True 15241667.485375745 18102044.054757643 11999600.333189877 1.0 1.1876682175442028 0.7872892086580024 23.861517410959014 -6.779230447940627 1.538703839019322 1.1063684424084534 0.7841846293058006 0.7647092164673257 0.079337976256237 0.2517736642246927 1.1773396315228124 0.04061177432764451 0.09589516697563556 1.6625302345182313e-07 6.779230447940627 -0.32218381310265287 ISATSIFFESMPYK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ISATSIFFESMPYK 14 0 P34897;P34897-3;P34897-2;G3V2Y4;G3V5L0;G3V4W5;G3V540;G3V2D2;P34896-2;P34896;P34896-3;P34896-4 P34897;P34896-2 SHMT2;SHMT1 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase;Serine hydroxymethyltransferase, cytosolic 0 58924100.0 23479400.0 11317800.0 24126900.0 False True 22734059.298973784 15837056.56154729 17807341.098514803 1.0 0.69662247086081 0.7832891110352046 24.438351972987924 -10.122541324130085 7.249716847594155 1.000000113167114 0.7399557909480075 0.9231011060145171 0.0353815076914434 6.470227731174247e-08 7.851204553924504e-09 0.03425801257232499 0.011419332504389154 7.541516331514452e-11 10.122541324130085 -0.26004432221910645 ISATSIFFESMPYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISATSIFFESMPYK 14 0 P34897;P34897-3;P34897-2;G3V2Y4;G3V5L0;G3V4W5;G3V540;G3V2D2;P34896-2;P34896;P34896-3;P34896-4 P34897;P34896-2 SHMT2;SHMT1 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase;Serine hydroxymethyltransferase, cytosolic 0 43187500.0 5398300.0 28467000.0 9322200.0 False True 8189615.768593745 23386841.4363138 7479663.083934595 1.0 2.8556701678239538 0.9133106235115768 22.96536433599536 -6.656558153405486 1.985369552208887 2.197873728731954 0.921500162215887 0.22093979490058246 0.7907637172221577 0.4926796706076118 3.729552095912842 0.3222204834272836 0.8761585999020012 2.2051688375366875e-07 6.656558153405486 -1.276373566516067 ISATSIFFESMPYK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ISATSIFFESMPYK 14 0 P34897;P34897-3;P34897-2;G3V2Y4;G3V5L0;G3V4W5;G3V540;G3V2D2;P34896-2;P34896;P34896-3;P34896-4 P34897;P34896-2 SHMT2;SHMT1 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase;Serine hydroxymethyltransferase, cytosolic 0 60220500.0 11625900.0 21089900.0 27504700.0 False True 15924309.408134144 20158078.48302702 21008656.33707764 1.0 1.2658683002435425 1.3192820987481195 23.924727472481905 -12.925276788910557 0.24111544374323182 3.1851349043601684e-06 1.3436337313968207 0.9994589715909767 0.0032478948739251444 8.185795899938192 0.14990126884364305 3.9564548495929452 0.025927647657442033 1.1877450006167275e-13 12.925276788910557 1.3436305462619165 ISATSIFFESMPYK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ISATSIFFESMPYK 14 0 P34897;P34897-3;P34897-2;G3V2Y4;G3V5L0;G3V4W5;G3V540;G3V2D2;P34896-2;P34896;P34896-3;P34896-4 P34897;P34896-2 SHMT2;SHMT1 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase;Serine hydroxymethyltransferase, cytosolic 0 46759500.0 23479400.0 10145500.0 13134600.0 False True 19524161.41378336 10090844.17777593 15880984.13247122 1.0 0.5168388011098984 0.8134015999918857 24.2187572484222 -10.361496896638155 6.091709707522622 1.000043183058428 0.6651202005508932 0.6296480858698674 0.12107125565875025 7.101519460217609e-05 7.443437246779073e-06 0.11724181232092247 0.03907557973922995 4.350138691220007e-11 10.361496896638155 -0.3349229825075348 ISATSIFFESMPYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISATSIFFESMPYK 14 0 P34897;P34897-3;P34897-2;G3V2Y4;G3V5L0;G3V4W5;G3V540;G3V2D2;P34896-2;P34896;P34896-3;P34896-4 P34897;P34896-2 SHMT2;SHMT1 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase;Serine hydroxymethyltransferase, cytosolic 0 22460300.0 5398300.0 17062000.0 0.0 False True 6988205.766401582 16112484.701296594 0.0 1.0 2.305668327450145 0.0 22.73649065808781 -6.755663515936078 1.645854229011146 1.764769466966474 2.435190316659174e-10 0.6619929993362232 0.5488485232009183 0.29266099143884905 1.5642801150404548 0.2640322122055976 0.632993719575885 1.7552399055247424e-07 6.755663515936078 -1.764769466722955 ISAVSVAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISAVSVAER 9 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 7517700.0 1510400.0 3346300.0 2661000.0 False True 1980149.0267344064 2847045.0837752377 2385665.2461144025 1.0 1.4377933404691698 1.2047907576172485 20.91717758146744 -10.10600649706784 4.306205343140801 0.9999580042812302 1.3212920489834994 0.717132904797714 0.09512290625535672 66776889.42600519 60359773.37968154 35154.95771107932 0.03481142620137717 7.834179227060315e-11 10.10600649706784 0.32133404470226923 ISAVSVAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISAVSVAER 9 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 6916100.0 1510400.0 2537600.0 2868100.0 False True 2068835.6970252472 2425480.441278968 2190713.850373662 1.0 1.1723891098585237 1.0589114706033262 20.98038764299033 -10.317649793845066 4.693671488456812 0.9999274864751019 1.1156502902311074 0.580691385888152 0.04632705223243463 32942551.882394098 2.995965464386213 25816.964634858537 0.015858982206424142 4.8122724380397144e-11 10.317649793845066 0.11572280375600552 ISAWHNNVEK(ub)TLPSTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISAWHNNVEKTLPSTK 16 1 Q14258 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 5298100.0 1413000.0 2380200.0 1504900.0 True False 1852456.6835114632 2025083.437946931 1349187.38402013 1.0 1.0931880113429921 0.7283233103527417 20.821008377326898 -6.838954903158843 1.2871382824398985 1.0495845781718596 0.716561416932085 0.9226562151311062 0.04304616254803157 0.17002493528708318 0.5476106996839725 0.0262275335077988 0.06041070438353624 1.4489223008314866e-07 6.838954903158843 -0.3330231612397746 ISAWHNNVEK(ub)TLPSTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISAWHNNVEKTLPSTK 16 1 Q14258 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 4115000.0 1413000.0 1145400.0 1556600.0 True False 1935424.284889216 1094792.4406687138 1188963.1391833057 1.0 0.5656601755058477 0.6143165343465565 20.88421843884979 -10.723402764151572 10.509493260568048 1.000508041752377 0.5899883551459805 0.9895483431082901 0.019863875316915656 0.00023671156579508108 6.22994409548881e-06 0.01925403553418636 0.006411038191129578 1.890589475094641e-11 10.723402764151572 -0.4105196866063966 ISAYSALSHPYFQDLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISAYSALSHPYFQDLER 17 0 Q00534 Q00534 CDK6 Cyclin-dependent kinase 6 0 9202400.0 2330500.0 4481000.0 2390900.0 False True 3055308.0685941046 3812452.2668011924 2143512.6031322554 1.0 1.2478127184586942 0.7015700397500634 21.542886424531904 -6.783350992140833 1.5226106326577633 1.1397092559434028 0.6967646034699572 0.7791123992712468 0.10495818448143315 0.24541456760847788 1.1239363486058216 0.05427925634609567 0.1277332544503556 1.646830902483469e-07 6.783350992140833 -0.4429446524734456 ISAYSALSHPYFQDLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISAYSALSHPYFQDLER 17 0 Q00534 Q00534 CDK6 Cyclin-dependent kinase 6 0 9565710.0 2102000.0 845210.0 6618500.0 False True 2035273.1605766292 1182706.7607119225 4884916.299256024 1.0 0.5811046809937004 2.4001280977301542 20.95679100556617 -6.846118170470844 1.2537629255745533 0.7770077892377619 2.467544278112754 0.9344517424264658 0.19913400478198318 0.1617795627560034 0.4913403985735134 0.12440165465400752 0.2872339221582938 1.4252197420170252e-07 6.846118170470844 1.6905364888749919 up ISAYSALSHPYFQDLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISAYSALSHPYFQDLER 17 0 Q00534 Q00534 CDK6 Cyclin-dependent kinase 6 0 9304500.0 2330500.0 3731700.0 3242300.0 False True 3192148.8293944253 3566821.1549183195 2476535.5172645706 1.0 1.117373075488768 0.7758208183966122 21.606096486054795 -6.813925370048926 1.3978275287892439 1.0636792010102019 0.769285977076924 0.8698496021047788 0.051117473378426044 0.20150510453357098 0.7751950787292149 0.02874731157074401 0.06639264764236529 1.5348807168232419e-07 6.813925370048926 -0.2943932239332778 ISAYSALSHPYFQDLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISAYSALSHPYFQDLER 17 0 Q00534 Q00534 CDK6 Cyclin-dependent kinase 6 0 6524700.0 2102000.0 1698100.0 2724600.0 False True 1747906.1343889807 1688951.9982535408 3294301.2628729544 1.0 0.9662715663183775 1.8847129133879665 20.737196281000447 -6.898375866119569 0.9714995447815085 0.9600941578818659 1.9779940971634609 0.9857401404564197 0.05077875654053502 0.11261003701128375 0.18424842990327908 0.03931906834366731 0.10149053859283363 1.2636422375666514e-07 6.898375866119569 1.017899939281595 ISDMCK(ub)ENR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISDMCKENR 9 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 11899300.0 3796800.0 4353200.0 3749300.0 True False 4977641.568263497 3703719.5286406945 3361358.401825151 1.0 0.7440711585693335 0.6752913715717374 22.247030917299544 -13.999999999999998 0.1844188897750775 2.346525963607357 0.6230780843857967 0.9994934680137236 0.003144308963732394 12.265136529433951 0.13616718909064418 5.924521897762494 0.04948810436550687 1.0000000000000041e-14 13.999999999999998 -1.7234478792215606 ISDMCK(ub)ENR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISDMCKENR 9 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 6591400.0 2567500.0 2439600.0 1584300.0 True False 2485996.117878447 3413745.002345932 1169324.3020187838 1.0 1.373189997279331 0.47036449236963696 21.24539261280955 -6.794488946771636 1.4787181173487165 1.2073655320435996 0.4595885130858295 0.8154336296424476 0.15913552252569824 0.2287247490861617 0.9879153278502123 0.084693629800781 0.1976283260453406 1.60513310981798e-07 6.794488946771636 -0.7477770189577702 down ISDMCK(ub)ENR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISDMCKENR 9 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 11117300.0 3796800.0 3734300.0 3586200.0 True False 5200579.564661977 3569306.278321267 2739213.420107396 1.0 0.6863285589503835 0.5267131068853164 22.310240978822435 -13.999999999999998 0.08683283112759288 2.629686574248127 0.10494140907461377 0.9998570206114878 0.0023508287152967226 12.192665349191714 0.08482730403191445 3.7097552744603153 0.380101163287169 1.0000000000000041e-14 13.999999999999998 -2.524745165173513 ISDMCK(ub)ENR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISDMCKENR 9 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 6685100.0 2567500.0 2612200.0 1505400.0 True False 2134990.0095355413 2598127.560118894 1820172.1798168325 1.0 1.2169272682845511 0.8525436520486595 21.025797888243826 -6.745432430810434 1.666680548715281 1.128251415413845 0.8520612376599719 0.6291207899922322 0.0911411812366584 0.30807720734914806 1.6822403472003498 0.04322499173776711 0.1054495969679639 1.7970806550770184e-07 6.745432430810434 -0.2761901777538731 ISDSEGFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISDSEGFK 8 0 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 10548200.0 3049900.0 1468400.0 6029900.0 False True 2953082.5939308517 2054739.7776048402 4450488.296877526 1.0 0.695794889661306 1.5070652971319287 21.4937902766894 -6.80513437274565 1.4348269709938117 0.8332333100747014 1.5197403929736295 0.8467590051833054 0.13099561944318133 0.21350977867105217 0.8671763851654306 0.07180549984939644 0.16650128338554918 1.5662663849788258e-07 6.80513437274565 0.6865070828989281 ISDSEGFK(ub)ANLSLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISDSEGFKANLSLLR 15 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 18033300.0 6822900.0 5589100.0 5621300.0 True False 6606310.774166644 7820856.77677145 4148912.8946147785 1.0 1.1838463318065773 0.6280226644557371 22.655413407824874 -6.817584009491218 1.382457933381289 1.0993409649749877 0.6165224333624378 0.8786895695860582 0.08052828608226285 0.19664820497726393 0.7391591247953245 0.04578344705864581 0.10558918295667287 1.522004689334536e-07 6.817584009491218 -0.48281853161254984 ISDSVLVDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISDSVLVDIK 10 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 11885800.0 3245600.0 3824600.0 4815600.0 False True 4255013.030435108 3253984.588174035 4317327.906497005 1.0 0.7647413920707289 1.0146450494078805 22.02073211931187 -11.067544739430929 11.50615518743425 1.660362583946942 0.8896932207393035 0.20620767102914594 0.10202274088855916 0.040890159784807825 0.00024003843294504817 0.002337174311619348 0.03292769803298535 8.559635289423569e-12 11.067544739430929 -0.7706693632076386 ISDSVLVDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISDSVLVDIK 10 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 15005500.0 5121600.0 3001100.0 6882800.0 False True 4959017.611422098 4199454.880529754 5079988.200425987 1.0 0.8468320158527276 1.0243940631961574 22.24162291826221 -6.678488757296431 1.907333793378628 0.9029576992103692 1.0237094110915075 0.3172071790869013 0.06493775433986763 0.44187702675096324 3.10666899848441 0.02733284642742422 0.07222638749295662 2.0965790543219195e-07 6.678488757296431 0.12075171188113831 ISDSVLVDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISDSVLVDIK 10 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 11829800.0 3245600.0 4316000.0 4268200.0 False True 4445586.029042068 4125304.8488966045 3260139.0663382947 1.0 0.9279552396347446 0.7333429260035684 22.08394218083476 -6.953781873820781 0.5156561705651209 1.003421520320819 0.6492559324295033 0.9994656237142236 0.002603622517152853 0.08200173198509542 0.02994551667912983 0.0029703938890682747 0.0160686908543548 1.1122902393328523e-07 6.953781873820781 -0.3541655878913157 ISDSVLVDIKDTEPLIQTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISDSVLVDIKDTEPLIQTAK 20 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 18357700.0 5112500.0 3510100.0 9735100.0 False True 4950206.485941017 4911701.234929683 7185185.263260157 1.0 0.992221485887368 1.4514920304166419 22.239057274320466 -6.903050260113542 0.9417977767954919 0.9824698514056674 1.5027985867978604 0.9880231073479918 0.023495706155431707 0.10919476582385254 0.16503452378213582 0.01859829167308685 0.04917299401185411 1.250114348377401e-07 6.903050260113542 0.5203287353921929 ISDSVLVDIKDTEPLIQTAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISDSVLVDIKDTEPLIQTAK 20 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 102757000.0 6548100.0 90117000.0 6091900.0 False True 9933946.430233367 74034917.26266523 4887833.2948253825 1.0 7.452719599669314 0.4920333856391209 23.2439355362478 -6.663186580204167 1.961676196677725 5.142626331432862 0.520923489175992 0.2491985797808075 2.7453493077291773 0.4769343773835141 3.531442649751885 1.1293945134258558 3.0443585957862305 2.1717679504226193e-07 6.663186580204167 -4.6217028422568704 ISDSVLVDIKDTEPLIQTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISDSVLVDIKDTEPLIQTAK 20 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 21376800.0 6548100.0 9995400.0 4833300.0 False True 8476644.53234801 9439147.203337245 3953688.993845965 1.0 1.113547603337169 0.4664214688675641 23.01506185834025 -6.861611553583048 1.17765304425025 1.0618832590442964 0.4341190571196805 0.955564575496432 0.059471995607514205 0.14514567499002548 0.38160555623306636 0.03936320802356832 0.09205316474337087 1.3752715104381366e-07 6.861611553583048 -0.6277642019246159 down ISEECIAQWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISEECIAQWK 10 0 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 0 12049200.0 1370300.0 6089100.0 4589800.0 False True 1796476.5700040776 5180630.015125901 4114891.524470462 1.0 2.8837726590078168 2.290534479089322 20.77673868887836 -10.073809951361335 5.1526696279076925 0.9999731918023516 2.5871535690524037 0.9051569638717882 0.24218847280298167 7.45873196793248e-05 1.340683436569998e-05 0.2345019150599524 0.07816599348219244 8.437038844807972e-11 10.073809951361335 1.5871803772500521 ISEECIAQWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISEECIAQWK 10 0 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 0 11130800.0 1370300.0 6519100.0 3241400.0 False True 1876936.9409651074 6231064.60621915 2475848.0787284896 1.0 3.319804981309165 1.3190896426469323 20.839948750401252 -6.610220626737733 2.15224935482457 2.549661714461122 1.3261821880927949 0.051072115162979936 1.0000942280338332 0.6122436618501221 5.374201773445978 0.3836154129599296 1.1106600296567855 2.4534622111955744e-07 6.610220626737733 -1.2234795263683274 ISEK(ub)EEVTTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISEKEEVTTR 10 1 Q03252 Q03252 LMNB2 Lamin-B2 1 10539900.0 4081800.0 4320400.0 2137700.0 True False 5351279.328207435 3675813.1607872965 1916511.3102663506 1.0 0.6869036234777555 0.3581407720886701 22.35145240659869 -7.146700835288334 0.2679054968041048 1.092648494815622 4.777316261920056e-16 0.9999662977006227 0.001521366750574521 0.0822177964764888 0.011960915529233751 0.009050333980366452 0.03488390678062478 7.133442496778829e-08 7.146700835288334 -1.0926484948156217 down ISEK(ub)EEVTTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISEKEEVTTR 10 1 Q03252 Q03252 LMNB2 Lamin-B2 1 12115300.0 4599500.0 4379800.0 3136000.0 True False 4453491.3901390135 6128676.980355274 2314587.522016606 1.0 1.376151078662795 0.5197242610913315 22.086505374234218 -6.787362349263337 1.507280833215892 1.210955867242886 0.5113182491379862 0.7925302301246931 0.15964648417502864 0.23930825874327163 1.0741636664535097 0.08338957814135854 0.1955815825353714 1.6316899955568481e-07 6.787362349263337 -0.6996376181048998 ISEK(ub)EEVTTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISEKEEVTTR 10 1 Q03252 Q03252 LMNB2 Lamin-B2 1 31765800.0 13994000.0 12393000.0 5378800.0 True False 21229921.09843857 10181372.323049054 4315677.82238821 1.0 0.4795765502773291 0.20328280083460237 24.33959567365064 -8.971927695862147 0.2397074555472615 1.325688659524405 1.8268743915106587e-12 0.9992738062863283 0.008901162522902137 0.4445481045001188 0.07922367406163544 0.23742242436574434 0.11807347703219839 1.0667737097933459e-09 8.971927695862147 -1.325688659522578 ISEK(ub)EEVTTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISEKEEVTTR 10 1 Q03252 Q03252 LMNB2 Lamin-B2 1 10884200.0 4081800.0 4342600.0 2459800.0 True False 5590951.766497394 4150729.5729421726 1878845.9011712044 1.0 0.7424012487130633 0.33605117333148793 22.41466246812158 -6.9644069859705855 0.3680878212599494 1.0319339354112436 0.03241643278983366 0.9999003943378898 0.0027277410060784074 0.07816277456857236 0.015572999246210608 0.005372080316526332 0.03454689008274308 1.0854079895195375e-07 6.9644069859705855 -0.9995175026214099 down ISEK(ub)EEVTTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISEKEEVTTR 10 1 Q03252 Q03252 LMNB2 Lamin-B2 1 13402000.0 4599500.0 7342600.0 1459900.0 True False 3824688.0423987233 7303043.956408012 1765158.3401850644 1.0 1.9094482675318465 0.46151694481153366 21.866910649668494 -6.736915328447012 1.6980569379598176 1.5430405099395768 0.4612361269061786 0.5910033938855481 0.3821485004693475 0.3234178632541095 1.8298327904455238 0.17812910970670548 0.43859036636550736 1.8326716915490327e-07 6.736915328447012 -1.081804383033398 ISEK(ub)EEVTTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISEKEEVTTR 10 1 Q03252 Q03252 LMNB2 Lamin-B2 1 27008200.0 13994000.0 9231500.0 3782700.0 True False 18115508.86297979 8717758.909859318 3094287.413779641 1.0 0.4812317984439632 0.1708087494082497 24.110721995743088 -8.520593166495342 0.28978452456087495 1.1901991607675266 4.524971199427889e-25 0.9989012647524451 0.011338298006242191 0.17812222923822174 0.07987906590112212 0.12635999839228643 0.0997711136437435 3.0158298365358826e-09 8.520593166495342 -1.1901991607675266 ISELDAFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISELDAFLK 9 0 Q06323;Q06323-3;Q06323-2 Q06323 PSME1 Proteasome activator complex subunit 1 0 13490700.0 2398400.0 4534100.0 6558200.0 False True 3144325.62613864 3857629.95378337 5879620.374696542 1.0 1.2268544713419827 1.8699145933931005 21.584319200053457 -6.952717843088717 0.528167301739243 0.9897226689646217 2.1361472512033943 0.99939765449699 0.00904255187388018 0.08241246505109268 0.031585604779656815 0.01011580555356789 0.05316528459237367 1.1150187151604991e-07 6.952717843088717 1.1464245822387726 ISELDAFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISELDAFLK 9 0 Q06323;Q06323-3;Q06323-2 Q06323 PSME1 Proteasome activator complex subunit 1 0 12801600.0 5507800.0 1899200.0 5394600.0 False True 5332957.90381729 2657560.4641971644 3981592.425469 1.0 0.4983276658334211 0.7466011352947314 22.346504509347007 -10.221297300937653 4.779459706373538 1.0000716435611188 0.6224644005630025 0.7550907353503147 0.10135721947883908 7.739216914053766e-05 1.2609291486588992e-05 0.09815726747500413 0.032712901921090186 6.007623383943039e-11 10.221297300937653 -0.3776072429981163 ISELDAFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISELDAFLK 9 0 Q06323;Q06323-3;Q06323-2 Q06323 PSME1 Proteasome activator complex subunit 1 0 11064500.0 2398400.0 4556100.0 4110000.0 False True 3285153.2943229307 4354796.436992079 3139302.648107025 1.0 1.3255991568240049 0.9556030927177888 21.64752926157635 -6.674335141318023 1.922178161186132 1.207049141781279 0.9570717990375369 0.29835720219352235 0.13817074049781167 0.4512133045309104 3.2181111196395342 0.057787627893952295 0.15351688893970872 2.1167270447600203e-07 6.674335141318023 -0.24997734274374206 ISELGAGNGGVVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISELGAGNGGVVFK 14 0 Q02750;Q02750-2 Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 0 6959200.0 1922000.0 2333600.0 2703600.0 False True 2519760.6126744784 1985435.976301555 2423857.406762456 1.0 0.7879462700999242 0.9619395567064482 21.26485524776671 -10.01974533288969 5.732336015569239 1.000000300579341 0.8749429134618051 0.4078620289614169 0.07103246180943727 2.7284277105224933e-07 4.657370557808968e-08 0.06877705092037058 0.02292562846898575 9.555527509169246e-11 10.01974533288969 -0.1250573871175359 ISELGAGNGGVVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISELGAGNGGVVFK 14 0 Q02750;Q02750-2 Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 0 5378500.0 1922000.0 0.0 3456500.0 False True 2632615.340097013 0.0 2640145.888852051 1.0 0.0 1.002860481985477 21.328065309289602 -12.028032706182255 17.936919791151766 0.8753179441162351 0.5512872168934779 0.0 0.4862026912647324 0.0 0.0 0.0 0.13943849891735643 9.374914029450696e-13 12.028032706182255 -0.32403072722275716 ISEQFTAMFR ddPTM_RPMI8226_Bortezomib_1h_R1 2 ISEQFTAMFR 10 0 A0A0B4J269;Q13509;Q13509-2;P04350;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 A0A0B4J269;P04350;P07437;P68371;Q13885;Q9BVA1 TUBB3;TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 164863400.0 47532400.0 55405000.0 61926000.0 False True 62315436.7044164 47138789.96699848 55518491.556137 1.0 0.7564544591189181 0.8909267830293855 25.893086254399435 -10.101666499090838 4.791226128348555 1.0000087529861794 0.823690621164954 0.6962377384204759 0.054898096357284036 5.133172016219053e-06 9.624032648724078e-07 0.05315749200609908 0.017718284409982958 7.912860345514639e-11 10.101666499090838 -0.17631813182122547 ISEQFTAMFR ddPTM_RPMI8226_Bortezomib_2h_R1 2 ISEQFTAMFR 10 0 A0A0B4J269;Q13509;Q13509-2;P04350;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 A0A0B4J269;P04350;P07437;P68371;Q13885;Q9BVA1 TUBB3;TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 169455900.0 12744000.0 40038900.0 116673000.0 False True 12339448.695712922 56026641.57010511 86112841.18502648 1.0 4.540449330574256 6.978661957154094 23.556774603129302 -8.139813056030619 0.2979424881623431 2.4109005977621212e-23 8.483679833926692 0.9989968902653503 0.07774079667899692 0.09417763764175895 0.06712392708882843 0.5680479703362233 0.7286674961415196 7.247478638447968e-09 8.139813056030619 8.483679833926692 ISEQFTAMFR ddPTM_RPMI8226_Bortezomib_8h_R1 2 ISEQFTAMFR 10 0 A0A0B4J269;Q13509;Q13509-2;P04350;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 A0A0B4J269;P04350;P07437;P68371;Q13885;Q9BVA1 TUBB3;TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 462299400.0 48023400.0 346999000.0 67277000.0 False True 72855008.78081708 285074317.33443856 53979671.461443394 1.0 3.9128993614163066 0.7409191538750647 26.118524825174507 -6.665214412231961 1.9542804166862033 2.866862172811784 0.7539472067566678 0.25808600558668304 1.2387118589727697 0.47217468020508147 3.471859028098426 0.5111220968230776 1.3741975201487928 2.1616510479110904e-07 6.665214412231961 -2.112914966055116 ISEQFTAMFR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ISEQFTAMFR 10 0 A0A0B4J269;Q13509;Q13509-2;P04350;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 A0A0B4J269;P04350;P07437;P68371;Q13885;Q9BVA1 TUBB3;TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 171564000.0 47532400.0 50296500.0 73735100.0 False True 65106412.79481124 48074234.3217165 56320388.00205256 1.0 0.7383947641721071 0.8650513149841532 25.956296315922327 -10.109705248778152 4.715283542574949 1.000012210350784 0.8017230395766456 0.7656758596427037 0.05170732035460814 50432833299.352425 9522286218.501331 7127366.819514063 0.017702197278122167 7.767741264232542e-11 10.109705248778152 -0.19828917077413843 ISEQFTAMFR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ISEQFTAMFR 10 0 A0A0B4J269;Q13509;Q13509-2;P04350;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 A0A0B4J269;P04350;P07437;P68371;Q13885;Q9BVA1 TUBB3;TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 102844600.0 12744000.0 40414100.0 49686500.0 False True 10597200.65492539 40196381.2217292 60075717.4255807 1.0 3.793113156071706 5.669017637941826 23.33717987856358 -8.198057448437313 0.2734832177978185 4.019284478075174e-18 7.017729494782807 0.9992496925292184 0.05254664755652842 0.09306704485751144 0.06229946234267261 0.5266256131722321 0.6135577062338269 6.337858685706392e-09 8.198057448437313 7.017729494782807 ISEQFTAMFR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ISEQFTAMFR 10 0 A0A0B4J269;Q13509;Q13509-2;P04350;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 A0A0B4J269;P04350;P07437;P68371;Q13885;Q9BVA1 TUBB3;TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 229251400.0 48023400.0 119262000.0 61966000.0 False True 62167237.98273711 112624964.86027628 50688823.82485236 1.0 1.8116449839954367 0.815362327001368 25.889651147266957 -6.690076016388032 1.8660251383202084 1.5088148719928243 0.8187946528194582 0.37080397335052495 0.3432638693635037 0.4165239839463651 2.8120185746473965 0.14715369697101233 0.3831787578295768 2.0413806019723938e-07 6.690076016388032 -0.6900202191733661 ISFCLDIHNMSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISFCLDIHNMSVK 13 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 7741400.0 3164100.0 2570000.0 2007300.0 False True 4148165.741187984 2186566.017781535 1799603.851381224 1.0 0.5271163579773765 0.43383123135910173 21.9840421079336 -13.999999999999886 0.22820531720142967 3.960594202286159 0.3876937046105221 0.9995073958783168 0.005500957683369486 13.236013717757736 0.15127040402975617 17.737966054091267 0.04896977946611438 1.0000000000002617e-14 13.999999999999886 -3.572900497675637 ISFCLDIHNMSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISFCLDIHNMSVK 13 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 23290900.0 12691000.0 7307400.0 3292500.0 False True 12288131.151702167 10225282.927587587 2430095.4771172404 1.0 0.8321267734981139 0.19775956547962303 23.55076218340575 -6.961244237479239 0.6064932143042951 1.006548965769584 1.1782133005100752e-15 0.9988730088515392 0.011597919251204724 0.08222625947251742 0.042822099047689334 0.011936183444829324 0.051346357558648845 1.0933413226990348e-07 6.961244237479239 -1.006548965769583 down ISFCLDIHNMSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISFCLDIHNMSVK 13 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 334664000.0 82614000.0 113570000.0 138480000.0 False True 125331477.8924115 93302546.17353992 111109367.30205987 1.0 0.7444462296505733 0.8865240334709822 26.901173562393176 -10.117577205867942 4.871613389384096 1.000009272746949 0.8154851317004636 0.6921931405110169 0.058003020526180844 5.84190193163724e-06 1.0582119106717955e-06 0.0561640045412823 0.018720394376783682 7.62821270019866e-11 10.117577205867942 -0.1845241410464854 ISFCLDIHNMSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISFCLDIHNMSVK 13 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 19269100.0 3164100.0 4341000.0 11764000.0 False True 4333953.276587381 4149200.2662326577 8985585.48718515 1.0 0.9573707886162999 2.0733000366493415 22.047252169456492 -6.898015421332189 0.9737034558731152 0.9510437034653114 2.185837242220661 0.9855535881744477 0.062055725282927666 0.11288178012888962 0.18576165816341586 0.04797072964636933 0.12361749946001452 1.264691438834545e-07 6.898015421332189 1.2347935387553497 up ISFCLDIHNMSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISFCLDIHNMSVK 13 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 25004100.0 12691000.0 2360200.0 9952900.0 False True 10553128.806627266 2347485.1341369813 12034005.37298989 1.0 0.22244446904341608 1.140325830708391 23.331167458840028 -6.682223129827262 1.8939336576112886 0.5090058361297205 1.1368963959549918 0.3342754620075874 0.329389702649604 0.43364591797918517 3.009239998670551 0.13945392938859896 0.36676356390690534 2.0786284645139165e-07 6.682223129827262 0.6278905598252713 ISFCLDIHNMSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISFCLDIHNMSVK 13 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 230357000.0 82614000.0 81306000.0 66437000.0 False True 106945451.5654005 76781249.62628187 54346147.701186374 1.0 0.71794778087713 0.5081669851845172 26.672299884485625 -7.428538184617701 0.1400645219252902 1.3159606507294974 5.2253281781839096e-11 0.9999917745686528 0.0005779057603110132 0.1251254828372679 0.010822965826218896 0.035110169093919875 0.060626935824825604 3.7278790674728934e-08 7.428538184617701 -1.315960650677244 ISFDEFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISFDEFIK 8 0 P13796;Q5TBN3 P13796 LCP1 Plastin-2 0 51494300.0 8758300.0 20816000.0 21920000.0 False True 11482216.11549786 17710333.94013247 19651928.6714873 1.0 1.542414265851376 1.7115100842739372 23.452897779246438 -11.396130600887336 0.21109451437013574 1.6226483140301248e-08 1.8263725565047444 0.9993509563255417 0.007732266133071261 3.829104947832415 0.12217868960599759 1.869271433678458 0.09831239259516923 4.016700026200074e-12 11.396130600887336 1.8263725402782613 ISFDEFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISFDEFIK 8 0 P13796;Q5TBN3 P13796 LCP1 Plastin-2 0 44856200.0 14457000.0 7309200.0 23090000.0 False True 13998070.448361704 10227801.676974466 17042036.31484804 1.0 0.7306579656606529 1.2174561042334655 23.738724638065136 -6.756522613834919 1.6256744241057666 0.8428756756257869 1.2189283200320264 0.676568784211667 0.11323612646783209 0.28879815218780613 1.5034550090419965 0.0549814445068256 0.13258070968970923 1.7517712166174128e-07 6.756522613834919 0.37605264440623953 ISFDEFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISFDEFIK 8 0 P13796;Q5TBN3 P13796 LCP1 Plastin-2 0 53137300.0 8758300.0 23699000.0 20680000.0 False True 11996480.194157995 22651899.817887094 15795809.917969136 1.0 1.8882121631741648 1.316703704946833 23.51610784076933 -10.121259752164564 4.411855044937025 0.9999362352379536 1.6024579340795888 0.597042977873699 0.2333173513527188 35140293.43746089 40307789.9340891 22031.145535224045 0.07987073665742261 7.5638036750215e-11 10.121259752164564 0.6025216988416352 ISFDEFIK(ub)IFHGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISFDEFIKIFHGLK 14 1 P13796;Q5TBN3 P13796 LCP1 Plastin-2 1 20152900.0 8860200.0 4533100.0 6759600.0 True False 11469703.56065268 4280829.000084847 5529422.159353061 1.0 0.3732292624170705 0.4820893696260804 23.45132476898263 -10.137769563563884 5.639737852987845 1.0000078505618057 0.42765931602276336 0.9735842414994896 0.04444195266799633 4.386972830198627e-06 6.705893480968169e-07 0.04303132573765575 0.014343578546310834 7.281660666053428e-11 10.137769563563884 -0.5723485345390424 ISFDLSLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISFDLSLAR 9 0 B3KWE1;P12081-3;P12081-2;P12081-4;P12081;E7ETE2;B4E1C5;B4DDD8;D6RJE6;B4DQ67;D6RB22;A0A2R8Y6I1;A0A2R8Y3N3;A0A2R8Y5P7;P49590-2;P49590 B3KWE1 HARS;HARS2 Histidine--tRNA ligase, cytoplasmic;Probable histidine--tRNA ligase, mitochondrial 0 7743900.0 3253600.0 2278400.0 2211900.0 False True 3150316.248930599 3188177.0016990406 1632537.0344223618 1.0 1.0120180800201548 0.5182136983791833 21.587065232178762 -6.901321755785578 0.9528641503554062 1.0197926487964633 0.46496463360264356 0.9872127792552797 0.026008679173324223 0.11043921950843835 0.1719792629501528 0.020419390086585474 0.05348948136075701 1.2550997533059646e-07 6.901321755785578 -0.5548280151938196 ISFDLSLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISFDLSLAR 9 0 B3KWE1;P12081-3;P12081-2;P12081-4;P12081;E7ETE2;B4E1C5;B4DDD8;D6RJE6;B4DQ67;D6RB22;A0A2R8Y6I1;A0A2R8Y3N3;A0A2R8Y5P7;P49590-2;P49590 B3KWE1 HARS;HARS2 Histidine--tRNA ligase, cytoplasmic;Probable histidine--tRNA ligase, mitochondrial 0 24374300.0 6328100.0 8045200.0 10001000.0 False True 9600190.346078984 6609471.202565497 8024297.966405977 1.0 0.6884729327544021 0.8358477985473849 23.194631580222737 -10.080418041767208 4.731961981761786 1.000010295498682 0.7621603656476011 0.776418633793227 0.06016553703145726 6.721513901702749e-06 1.3062640013523454e-06 0.05825762337094008 0.019418343576199634 8.309635198556582e-11 10.080418041767208 -0.2378499298510809 ISFDLSLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISFDLSLAR 9 0 B3KWE1;P12081-3;P12081-2;P12081-4;P12081;E7ETE2;B4E1C5;B4DDD8;D6RJE6;B4DQ67;D6RB22;A0A2R8Y6I1;A0A2R8Y3N3;A0A2R8Y5P7;P49590-2;P49590 B3KWE1 HARS;HARS2 Histidine--tRNA ligase, cytoplasmic;Probable histidine--tRNA ligase, mitochondrial 0 7011800.0 3253600.0 2060000.0 1698200.0 False True 2705512.558919118 2048902.371122014 2053285.7684103542 1.0 0.757306545987934 0.7589267185773717 21.36747050761304 -10.033483904542138 5.4272346541018655 1.0000013743467115 0.7581166322823951 0.9999663495957374 0.0006614326908028826 1.099946210939588e-08 1.957978715878668e-09 0.000640433089165378 0.00021347648287819374 9.257976956227926e-11 10.033483904542138 -0.24188474206431643 ISFDLSLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISFDLSLAR 9 0 B3KWE1;P12081-3;P12081-2;P12081-4;P12081;E7ETE2;B4E1C5;B4DDD8;D6RJE6;B4DQ67;D6RB22;A0A2R8Y6I1;A0A2R8Y3N3;A0A2R8Y5P7;P49590-2;P49590 B3KWE1 HARS;HARS2 Histidine--tRNA ligase, cytoplasmic;Probable histidine--tRNA ligase, mitochondrial 0 20905700.0 6328100.0 9516300.0 5061300.0 False True 8191850.195499684 8986709.539500002 4140195.333323521 1.0 1.0970305028816305 0.5054041803154554 22.965757902315186 -6.864806869984185 1.1611397555370926 1.0534870158463798 0.47399979071826054 0.959223763529167 0.052314604239284815 0.14193563567101336 0.3609291010909445 0.03506380353613298 0.0823490621364268 1.365190099331378e-07 6.864806869984185 -0.5794872251281193 ISFK(ub)NLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISFKNLK 7 1 Q12798;P41208 Q12798 CETN1;CETN2 Centrin-1;Centrin-2 1 11148700.0 3757800.0 4589000.0 2801900.0 True False 4926512.190586969 3904339.0877818996 2511986.265722638 1.0 0.7925158685777487 0.5098914137515506 22.232135196431525 -6.9668096747328745 0.3255008146113002 1.0362899625668698 0.2569270019080538 0.9999457351059593 0.001479679247164223 0.07735212408747809 0.012722705035194319 0.0041926723439422 0.024742613766925943 1.0794196635973572e-07 6.9668096747328745 -0.7793629606588159 ISFK(ub)NLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISFKNLK 7 1 Q12798;P41208 Q12798 CETN1;CETN2 Centrin-1;Centrin-2 1 14386100.0 4261200.0 5134900.0 4990000.0 True False 4125930.5384629522 7185292.348149757 3682969.3032088205 1.0 1.7414961985342874 0.8926396770074686 21.976288102458756 -6.675847152348499 1.9164018977396688 1.4708808694180555 0.8959473401520043 0.30534219480855407 0.31455118130518017 0.4478070072984822 3.1758998989495053 0.1318739825539565 0.349700950420128 2.1093704010932373e-07 6.675847152348499 -0.5749335292660512 ISFK(ub)NLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISFKNLK 7 1 Q12798;P41208 Q12798 CETN1;CETN2 Centrin-1;Centrin-2 1 18473500.0 3893700.0 3912800.0 10667000.0 True False 5907027.567599705 3214530.269154061 8558662.774487803 1.0 0.5441874500105425 1.4488950113306442 22.494000914236647 -6.769718070267789 1.5754403316877958 0.7384660940508236 1.4539415383771859 0.7295226829453303 0.19208889195583687 0.2668810807240864 1.3072156115848494 0.09610683185086182 0.2288419755360939 1.6993464544489662e-07 6.769718070267789 0.7154754443263622 ISFK(ub)NLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISFKNLK 7 1 Q12798;P41208 Q12798 CETN1;CETN2 Centrin-1;Centrin-2 1 8371600.0 3757800.0 2041800.0 2572000.0 True False 5147160.210726615 1951586.5246703194 1964546.5720027392 1.0 0.37915791325151266 0.38167581570681436 22.295345257954416 -10.005578442861458 7.236174727996891 1.0000000394722102 0.38041686447917955 0.9999876135113049 0.0010279293729324535 6.536803990500589e-10 8.91557353457128e-11 0.0009952883875187625 0.0003317627785369559 9.872373034942432e-11 10.005578442861458 -0.6195831749930306 ISFK(ub)NLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISFKNLK 7 1 Q12798;P41208 Q12798 CETN1;CETN2 Centrin-1;Centrin-2 1 11807900.0 4261200.0 4761900.0 2784800.0 True False 3543376.603167611 4736246.6995368535 3367088.8045396074 1.0 1.336647844686583 0.9502486417982184 21.756693377893033 -6.676369918575298 1.9143748688112623 1.213682283880073 0.9517424696585156 0.3078118762702793 0.14279235204012763 0.44661309192833876 3.16115677701994 0.05991581789974182 0.15878647720009598 2.10683285054748e-07 6.676369918575298 -0.2619398142215573 ISFK(ub)NLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISFKNLK 7 1 Q12798;P41208 Q12798 CETN1;CETN2 Centrin-1;Centrin-2 1 15355400.0 3893700.0 5085700.0 6376000.0 True False 5040471.406301589 4802676.324310409 5215633.423284684 1.0 0.9528228487331782 1.034751118072827 22.265127236329096 -6.75057035371236 1.647786792805104 0.9722776526450738 1.0349202849380343 0.6513555341036084 0.019824773892920207 0.299074286909011 1.5978854441829757 0.00950346580433045 0.023057559408080946 1.7759455499582547e-07 6.75057035371236 0.06264263229296052 ISFQPAVAGIK(ub)GDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISFQPAVAGIKGDK 14 1 Q9NQX7-2;Q9NQX7-3;Q9NQX7;C9JG41 Q9NQX7-2 ITM2C Integral membrane protein 2C;CT-BRI3 1 154355000.0 37975000.0 63152000.0 53228000.0 True False 49785592.75042316 53729967.76456791 47720477.15902953 1.0 1.079227238167436 0.958519815125108 25.56922497126977 -6.729679573333815 1.724797017661259 1.0476966131566794 0.9586011112428365 0.5576179482973609 0.033306002985411386 0.33683174552872697 1.963038730218751 0.015304738312070068 0.03798567609282941 1.8634615094997208e-07 6.729679573333815 -0.08909550191384286 ISFQPAVAGIK(ub)GDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISFQPAVAGIKGDK 14 1 Q9NQX7-2;Q9NQX7-3;Q9NQX7;C9JG41 Q9NQX7-2 ITM2C Integral membrane protein 2C;CT-BRI3 1 97986000.0 36236000.0 39504000.0 22246000.0 True False 35085708.01458362 55278153.21063852 16419105.234305289 1.0 1.5755176776726803 0.46797132403543273 25.06438013988575 -6.765479513949028 1.5916483442003124 1.3320069523191687 0.4627646492122184 0.712990684517681 0.24229578273194782 0.2738144545533446 1.3682128091813246 0.12003973831147029 0.2869583778128416 1.7160126540312824e-07 6.765479513949028 -0.8692423031069503 down ISFQPAVAGIK(ub)GDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISFQPAVAGIKGDK 14 1 Q9NQX7-2;Q9NQX7-3;Q9NQX7;C9JG41 Q9NQX7-2 ITM2C Integral membrane protein 2C;CT-BRI3 1 132402000.0 37975000.0 47072000.0 47355000.0 True False 52015383.73578776 44992203.393712044 36170724.30683897 1.0 0.8649787843967475 0.6953851285721208 25.63243503279266 -6.968039064595201 0.3013740217246581 1.0289370470288164 0.5261024373615667 0.9999627865441701 0.0007602270782382463 0.07694433284354933 0.011295931449691942 0.0027946118490060796 0.015188091691042169 1.0763683904180219e-07 6.968039064595201 -0.5028346096672497 ISFQPAVAGIK(ub)GDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISFQPAVAGIKGDK 14 1 Q9NQX7-2;Q9NQX7-3;Q9NQX7;C9JG41 Q9NQX7-2 ITM2C Integral membrane protein 2C;CT-BRI3 1 102595000.0 36236000.0 45599000.0 20760000.0 True False 30131839.52698341 45353349.13630722 25100820.016605213 1.0 1.505163635817613 0.8330331108436688 24.844785415320025 -6.705611769791225 1.81078210032238 1.3119531053112439 0.8348061902622039 0.4441923230279202 0.2130265678994626 0.3840066561159904 2.4516022137045916 0.09371677209660446 0.23936601033553648 1.9696462349007023e-07 6.705611769791225 -0.47714691504903994 ISFQPAVAGIK(ub)GDK(ub)ADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISFQPAVAGIKGDKADK 17 2 Q9NQX7-2;Q9NQX7-3;Q9NQX7;C9JG41 Q9NQX7-2 ITM2C Integral membrane protein 2C;CT-BRI3 2 55672000.0 17227000.0 18464000.0 19981000.0 True False 23596287.442170218 17648199.427717082 15261899.321612248 1.0 0.747922717544838 0.6467923972792802 24.492056553031613 -13.99999999962359 0.1259089417923741 2.198111283942021 0.4975228178497186 0.9996645093927554 0.0027203610409811865 11.944946085050574 0.10992039353695993 3.555956612117591 0.13258167321618597 1.0000000008667161e-14 13.99999999962359 -1.7005884660923023 ISFTGSTTTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISFTGSTTTGK 11 0 C9J8Q5;P51649;P51649-2 C9J8Q5 ALDH5A1 Succinate-semialdehyde dehydrogenase, mitochondrial 0 3875900.0 1096400.0 1210200.0 1569300.0 False True 1437391.0175527032 1029642.8773226534 1406923.889788549 1.0 0.7163276135367256 0.9788038693771529 20.455021144931372 -10.452520167043449 8.128549727808004 1.0000054058691645 0.8475657416078388 0.3102025879318454 0.10715548273421 1.0498103587183087e-05 7.071130524023745e-07 0.10375652786915956 0.03458428334036765 3.5276040533866485e-11 10.452520167043449 -0.1524396642613257 ISGATFSVGSGSVYAYGVMDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISGATFSVGSGSVYAYGVMDR 21 0 P28074;P28074-3 P28074 PSMB5 Proteasome subunit beta type-5 0 37079200.0 8461200.0 12499000.0 16119000.0 False True 12836258.996577714 10268455.794867264 12933072.58479131 1.0 0.7999570433726015 1.0075421965417968 23.613721468425716 -11.07900674501518 10.30450082850178 1.6273754532572533 0.9037496199571989 0.22278750781053125 0.08474628390700312 0.04294233356515099 0.0003292482518783624 0.002884802578818847 0.027351745518732384 8.336682368415409e-12 11.07900674501518 -0.7236258333000544 ISGATFSVGSGSVYAYGVMDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISGATFSVGSGSVYAYGVMDR 21 0 P28074;P28074-3 P28074 PSMB5 Proteasome subunit beta type-5 0 25048300.0 8461200.0 8956200.0 7630900.0 False True 10953190.195186844 8457779.596867463 6242154.499646028 1.0 0.7721749961562853 0.569893737660925 23.384847790518165 -6.972528847814924 0.18821805402970074 1.1403285627707127 0.19622431139920407 0.9999959766818601 0.00035236209890880833 0.07549032718211278 0.005991985964177112 0.007251146944650443 0.022160929220008046 1.0652980993719616e-07 6.972528847814924 -0.9441042513715087 ISGGLSNLSFSFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISGGLSNLSFSFR 13 0 Q99707;Q99707-2;B1ANE3 Q99707 MTR Methionine synthase 0 11245000.0 2688600.0 5032800.0 3523600.0 False True 3524780.63643944 4281925.857700747 3159011.6727578808 1.0 1.214806338140276 0.8962292972503841 21.74910204397926 -6.725066893671875 1.7409874521146633 1.1299758463381426 0.8965764294947485 0.5362902331722432 0.09034028294693013 0.3455978744308259 2.049749027649981 0.04115847782500962 0.10271627809203686 1.883358976431133e-07 6.725066893671875 -0.23339941684339416 ISGGLSNLSFSFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISGGLSNLSFSFR 13 0 Q99707;Q99707-2;B1ANE3 Q99707 MTR Methionine synthase 0 27393000.0 11013000.0 7792500.0 8587500.0 False True 10663398.34321143 10904085.887350658 6338176.130522191 1.0 1.0225713732519854 0.5943861353127845 23.346163951424696 -6.894459054505381 0.9956120912020311 1.0206083632343899 0.5541700348546668 0.9836028601039621 0.025193358780259766 0.11560044105473596 0.20130171495389945 0.01915840545116463 0.048597222466939566 1.2750903104104408e-07 6.894459054505381 -0.4664383283797231 ISGGLSNLSFSFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISGGLSNLSFSFR 13 0 Q99707;Q99707-2;B1ANE3 Q99707 MTR Methionine synthase 0 40226000.0 13531000.0 12080000.0 14615000.0 False True 20527516.248604562 9924229.618529202 11726338.844017955 1.0 0.48345983500092665 0.5712497655343519 24.291055741604723 -10.808337891073332 7.255020529290634 1.0192319232219087 0.5273548002676394 0.9747776388178719 0.03584008906021215 0.010517218158835105 0.00027784200849793937 0.0327358255179156 0.011567339004732693 1.5547555254428156e-11 10.808337891073332 -0.49187712295426933 ISGGLSNLSFSFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISGGLSNLSFSFR 13 0 Q99707;Q99707-2;B1ANE3 Q99707 MTR Methionine synthase 0 23164200.0 2688600.0 6084600.0 14391000.0 False True 3682648.076683054 5815762.252918516 10992142.191948455 1.0 1.57923378281553 2.984847306357069 21.81231210550215 -6.956096823174591 0.4873442241097713 0.9684857928910675 3.6549313659102007 0.999596909827032 0.01673209820599904 0.08112611947151523 0.02651656096299904 0.02012329585729876 0.11593217585856258 1.1063770967888004e-07 6.956096823174591 2.6864455730191334 ISGGLSNLSFSFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISGGLSNLSFSFR 13 0 Q99707;Q99707-2;B1ANE3 Q99707 MTR Methionine synthase 0 24089200.0 11013000.0 6716900.0 6359300.0 False True 9157797.458623145 6680714.726499733 7689000.227918961 1.0 0.7295110813145417 0.8396123918070345 23.126569226858972 -10.0357527927964 4.75114956085241 1.000005649891982 0.7845617366430345 0.8362009985773464 0.044948671805101974 2.6900807804601515e-06 5.460176370585756e-07 0.043522504922546563 0.014507121441954186 9.209736551726603e-11 10.0357527927964 -0.21544391324894752 ISGGLSNLSFSFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISGGLSNLSFSFR 13 0 Q99707;Q99707-2;B1ANE3 Q99707 MTR Methionine synthase 0 44172000.0 13531000.0 18172000.0 12469000.0 False True 17516146.235885344 17160712.225528184 10199769.94274415 1.0 0.9797082071837822 0.5823067360472176 24.062182063697172 -6.917493826453658 0.8431023079928676 1.0095852224030426 0.5217755109288444 0.9934560092304651 0.015555948919209793 0.09966904072260081 0.11342005246328538 0.013228114733312363 0.03872314286782209 1.2092223720570562e-07 6.917493826453658 -0.48780971147419816 ISGK(ub)MALNHPYFNDLDNQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISGKMALNHPYFNDLDNQIK 20 1 P06493;A0A024QZP7;P06493-2 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 15850300.0 3083300.0 10184200.0 2582800.0 True False 4042236.158719675 8664757.057700684 2315556.6319670347 1.0 2.1435553781313783 0.5728405122922003 21.94672217977539 -6.711485984234911 1.7899236269829704 1.701970286774849 0.5763738989855667 0.47211981419609883 0.481778618694762 0.37211318592126685 2.3248742856679536 0.21412318597978677 0.5429923664454435 1.9431844022191193e-07 6.711485984234911 -1.1255963877892823 ISGK(ub)MALNHPYFNDLDNQIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISGKMALNHPYFNDLDNQIK 20 1 P06493;A0A024QZP7;P06493-2 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 40405300.0 12245200.0 10479500.0 17680600.0 True False 11856482.828683592 14664018.999870539 13049520.453369504 1.0 1.2367933401290696 1.100623232194937 23.499172768685533 -10.202421408995068 4.502022537383389 0.9999610096002142 1.1687082861578448 0.6717728745822005 0.055591213840239004 2.4162155482549412e-05 4.2804706736140436e-06 0.053839763105476536 0.017941987107026772 6.274492304775488e-11 10.202421408995068 0.16874727655763067 ISGK(ub)MALNHPYFNDLDNQIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISGKMALNHPYFNDLDNQIK 20 1 P06493;A0A024QZP7;P06493-2 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 22130000.0 3083300.0 8470300.0 10576400.0 True False 4223279.333049488 8096054.138463603 8078472.147795403 1.0 1.9170065487043488 1.912843435331617 22.00993224129828 -10.175299978631497 5.5234393091667835 0.9999745196743249 1.9149249920180853 0.9999844716602159 0.0016995839177856924 5.332997260140764e-07 7.962550206296899e-08 0.0016456606830818263 0.0005485383507031662 6.678824342282227e-11 10.175299978631497 0.9149504723437604 ISGK(ub)MALNHPYFNDLDNQIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISGKMALNHPYFNDLDNQIK 20 1 P06493;A0A024QZP7;P06493-2 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 43039300.0 12245200.0 21620200.0 9173900.0 True False 10182426.354338687 21503727.691326324 11092120.074678916 1.0 2.1118471121731885 1.0893395825988579 23.27957804411981 -6.626344281283732 2.094404732162124 1.7344731324998204 1.0934435386653312 0.10426857767602637 0.4773727516080523 0.5685740502305888 4.7481753294767195 0.1867628343984456 0.5287472695820326 2.3640448887300356e-07 6.626344281283732 -0.6410295938344892 ISGLGLTPEQK(ub)QK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISGLGLTPEQKQK 13 1 O95831-3;O95831;O95831-6;O95831-4 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 1 32833000.0 17630000.0 15203000.0 0.0 True False 14660126.141426135 15121098.421440754 0.0 1.0 1.031443950452242 0.0 23.805394181245813 -7.000970902769378 1.1203625628389875 1.0323776372828255 4.903682350695322e-20 0.9833037117388298 0.06189200875064024 0.0918019287685788 0.22546048695114607 0.04651809525606408 0.08527494377457581 9.97766910818264e-08 7.000970902769378 -1.0323776372828255 down ISGLGLTPEQKQK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISGLGLTPEQKQK 13 1 O95831-3;O95831;O95831-6;O95831-4 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 1 24939000.0 9623200.0 8106700.0 7209100.0 True False 13181157.097201645 7748519.188728014 5506459.056075017 1.0 0.5878481783949773 0.4177523274678242 23.651973685932443 -13.999999999999993 0.12154826400079863 2.9623539981685143 0.1518473114194 0.9996853796521493 0.004335985744173139 11.958069274326915 0.10749315664535503 5.6570900179994315 0.23599286060133445 1.0000000000000164e-14 13.999999999999993 -2.810506686749114 ISGLIYEETR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISGLIYEETR 10 0 P62805 P62805 HIST1H4A Histone H4 0 325516600.0 67170000.0 99666000.0 158680600.0 False True 88060520.47520539 84796221.29502524 142261853.68379587 1.0 0.9629311845698294 1.6155009408995213 26.391992035454077 -6.893442693008901 1.0018095637947775 0.9677750872145708 1.675561629339653 0.9830112888890563 0.039007075738602154 0.1163939543615206 0.20589430604367615 0.029525779809507637 0.0745805762221601 1.2780778462095621e-07 6.893442693008901 0.7077865421250821 ISGLIYEETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISGLIYEETR 10 0 P62805 P62805 HIST1H4A Histone H4 0 310015300.0 116400000.0 16535000.0 177080300.0 False True 112704945.71413879 23137511.72888591 130697657.13487136 1.0 0.2052927809181609 1.1596443821229345 26.747975584287 -6.685695997651469 1.881571486915391 0.49976804081861886 1.1561958143889883 0.3503645726873652 0.3364058027877915 0.4260166303376583 2.92066381394661 0.14320687260774545 0.3749755101536218 2.0620728411918377e-07 6.685695997651469 0.6564277735703694 ISGLIYEETR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISGLIYEETR 10 0 P62805 P62805 HIST1H4A Histone H4 0 1851291000.0 66109000.0 1565202000.0 219980000.0 False True 100292186.21528338 1285879474.120955 176500856.57934076 1.0 12.821332574810317 1.7598664785357332 26.579633968761982 -6.63048795921316 2.0788476414653614 8.785405509212934 1.8044267246340888 0.11924311852074565 5.070117999327028 0.5576608494035334 4.593370386734814 1.994397618735423 5.6158358257788 2.3415963948802072e-07 6.63048795921316 -6.980978784578845 ISGLIYEETR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISGLIYEETR 10 0 P62805 P62805 HIST1H4A Histone H4 0 599823300.0 67170000.0 224940000.0 307713300.0 False True 92004564.2009971 215001407.02289218 235037756.09434327 1.0 2.3368558819885386 2.5546314808999013 26.45520209697697 -10.47331283583657 0.37685537327340757 8.53484956032214e-21 2.583241517815577 0.9991983481983804 0.019459968705494823 1.9457225042388127 0.17838754821988398 1.9431076482242589 0.05928970004942085 3.362692568982606e-11 10.47331283583657 2.583241517815577 ISGLIYEETR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISGLIYEETR 10 0 P62805 P62805 HIST1H4A Histone H4 0 310818000.0 116400000.0 109890000.0 84528000.0 False True 96791757.39432798 109298000.75854291 102202413.98668616 1.0 1.1292077311218216 1.0558999726631189 26.528380859721278 -10.289882672046877 5.578440613278822 0.999989883144625 1.0925538518924716 0.6800345215149857 0.029927767068509532 3.7660222861595177e-06 4.793945969027491e-07 0.02898060296374556 0.009659145287125106 5.129999561071813e-11 10.289882672046877 0.09256396874784656 ISGLIYEETR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISGLIYEETR 10 0 P62805 P62805 HIST1H4A Histone H4 0 560691000.0 66109000.0 263582000.0 231000000.0 False True 85579403.70321074 248913429.99280047 188960370.26015696 1.0 2.908567005865476 2.208012232890419 26.35076029085443 -10.289783263738931 5.573700415031172 0.9998285597229296 2.5582896193779785 0.8683702550409873 0.28600028844347647 0.0006093545896021781 7.76460655974858e-05 0.2769476948478183 0.0923061961793259 5.13117393230213e-11 10.289783263738931 1.5584610596550488 ISGLK(ub)SGEGSQHPFGAMNIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISGLKSGEGSQHPFGAMNIVR 21 1 A0A087WYW7;E9PPG8;Q53FT3 A0A087WYW7 C11orf73 Protein Hikeshi 1 9903100.0 2081100.0 2422200.0 5399800.0 True False 2015036.6196365485 3389397.0916061318 3985430.389472336 1.0 1.6820523550671136 1.9778451421846552 20.94237462668188 -10.414957558479175 0.18116881180403208 2.1666444143153548e-17 2.2797915913634177 0.9995055588083087 0.009104621150115939 2.1337712318694115 0.09198262639816217 1.1762034381290125 0.20756592591239165 3.846293681957668e-11 10.414957558479175 2.2797915913634177 ISGLK(ub)SGEGSQHPFGAMNIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISGLKSGEGSQHPFGAMNIVR 21 1 A0A087WYW7;E9PPG8;Q53FT3 A0A087WYW7 C11orf73 Protein Hikeshi 1 53033800.0 3950700.0 6567300.0 42515800.0 True False 5993500.734857882 5395314.004450896 34112533.49466286 1.0 0.9001941007651898 5.6915874384174465 22.514967480111906 -6.902145539365662 0.9476223219220669 0.8123486439362705 6.216993477601845 0.9876033499595425 0.24890460774083376 0.10984259214850241 0.16865424440819232 0.19617817756555161 0.5161315528776709 1.2527212966717863e-07 6.902145539365662 5.404644833665574 up ISGLK(ub)SGEGSQHPFGAMNIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISGLKSGEGSQHPFGAMNIVR 21 1 A0A087WYW7;E9PPG8;Q53FT3 A0A087WYW7 C11orf73 Protein Hikeshi 1 7151500.0 1500800.0 2157200.0 3493500.0 True False 2055686.3175950043 2061887.771093548 2668407.250890965 1.0 1.0030167314173686 1.298061493162438 20.971188706143867 -6.909135110200244 0.9015913555282484 0.990612955429125 1.335495652314208 0.9905913133357972 0.01356055823079425 0.10499327790431744 0.1418854175581034 0.011054931199219145 0.03033731355977739 1.232721270612008e-07 6.909135110200244 0.3448826968850831 ISGTVNIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISGTVNIR 8 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 43122000.0 17034000.0 10256000.0 15832000.0 False True 22331738.957490668 8725844.777574874 14193856.511267666 1.0 0.39073736237849005 0.6355911887688739 24.41259226143851 -10.296400068653229 5.696947930661047 1.0000477540562593 0.5131642755736953 0.8405348144909042 0.09996115603742615 6.06356302523416e-05 7.488667395890586e-06 0.09679642792902363 0.03226232438338031 5.0535891486607375e-11 10.296400068653229 -0.4868834784825641 ISGTVNIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISGTVNIR 8 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 32887700.0 7334500.0 4472200.0 21081000.0 False True 7101670.3122023195 6257972.782214907 15559253.683556128 1.0 0.8811973109287059 2.190928753313388 22.759726955592505 -6.884741094158701 1.05296322487327 0.9205019938912458 2.29263392471562 0.9773143988402073 0.08907564211499114 0.12351504851276819 0.24758938987281875 0.06486005412341872 0.158924526409375 1.3039438965032922e-07 6.884741094158701 1.3721319308243742 up ISGTVNIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISGTVNIR 8 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 31858400.0 9466800.0 12924000.0 9467600.0 False True 14361827.715785222 10617611.22432712 7596324.710203505 1.0 0.73929387223168 0.5289246508544531 23.775736025399503 -6.973561599878057 0.15047724394662731 1.242919263643228 0.019764087066837396 0.9999985233860831 0.0002340674671932825 0.07516301251533032 0.004601590380767826 0.010685290445641798 0.02619233307305859 1.0627678306998166e-07 6.973561599878057 -1.2231551765763906 ISGTVNIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISGTVNIR 8 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 33397500.0 17034000.0 6594300.0 9769200.0 False True 23331930.12654137 6302942.0215660045 7461916.162989564 1.0 0.2701423323052068 0.3198156398771836 24.4758023229614 -10.079534949270068 7.650918608301392 1.000000063943864 0.2949789860911954 0.9962907216982192 0.020279042897945236 2.2119115495100523e-08 2.6386925536248325e-09 0.019635100610681338 0.006545032951730635 8.32654916493495e-11 10.079534949270068 -0.7050210778526687 ISGTVNIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISGTVNIR 8 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 19157200.0 7334500.0 7649600.0 4173100.0 False True 6098961.723442421 7608390.0864732815 5045675.91576567 1.0 1.2474893976181405 0.8273008004578445 22.54013223102678 -6.747104820030259 1.660662497175378 1.146031444269375 0.8266516519655885 0.636385088597801 0.1039849801472654 0.3051181478670712 1.6546528642773959 0.04948498103513551 0.1204987715371617 1.7901737308582135e-07 6.747104820030259 -0.31937979230378655 ISGTVNIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISGTVNIR 8 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 36743900.0 9466800.0 17421000.0 9856100.0 False True 12254959.218526313 16451506.035710236 8062390.932126121 1.0 1.3424366203389593 0.6578880262561692 23.546862347491953 -6.770708998002458 1.5719170745163118 1.196233565584392 0.653949495053982 0.7332199626858686 0.14434619430141027 0.26527499987517805 1.293728316427134 0.07237979077120665 0.17216964894308306 1.6954734835599767e-07 6.770708998002458 -0.5422840705304101 ISGWTQALPDMVVSHLFGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ISGWTQALPDMVVSHLFGK 19 0 Q92597;Q92597-3;Q92597-2 Q92597 NDRG1 Protein NDRG1 0 1193313900.0 466347000.0 244843400.0 482123500.0 False True 451543069.75044215 342610646.4614637 355840891.95502925 1.0 0.7587551872976747 0.7880552615981785 28.750288362645303 -9.87099194520984 6.440782383682598 1.000000012121507 0.773405224546088 0.9876152622185501 0.011961705243727175 2.0805830213910552e-09 3.7513561452539144e-10 0.01158187181801255 0.003860623766754308 1.345885315743742e-10 9.87099194520984 -0.22659478757541895 ISGWTQALPDMVVSHLFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISGWTQALPDMVVSHLFGK 19 0 Q92597;Q92597-3;Q92597-2 Q92597 NDRG1 Protein NDRG1 0 28801000.0 18756000.0 5088300.0 4956700.0 False True 28454223.247271277 4180253.109930647 3977006.072401217 1.0 0.1469115172677057 0.13976856925035222 24.762139461056705 ISGWTQALPDMVVSHLFGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISGWTQALPDMVVSHLFGK 19 0 Q92597;Q92597-3;Q92597-2 Q92597 NDRG1 Protein NDRG1 0 10863880.0 997270.0 1631510.0 8235100.0 False True 1365987.669208402 1559424.4935179125 6290138.987208308 1.0 1.141609495217192 4.60482852737132 20.38151302978074 -6.915505173555587 0.8574049972113132 0.9105240521929086 5.109378400689586 0.9928384530295427 0.1410678245575483 0.10088900922712138 0.1198541093257396 0.11873525458905454 0.3417213001416408 1.2147721493486646e-07 6.915505173555587 4.198854348496678 up ISGWTQALPDMVVSHLFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ISGWTQALPDMVVSHLFGK 19 0 Q92597;Q92597-3;Q92597-2 Q92597 NDRG1 Protein NDRG1 0 1116466200.0 466347000.0 280244200.0 369875000.0 False True 387788193.1750229 278734468.87048155 447214152.3912266 1.0 0.718780184069912 1.1532433433046339 28.53069363807958 -6.7319813049983255 1.7159531378513044 0.8311327642714236 1.1530803532297154 0.568372378119126 0.11820156834165496 0.3325756930954142 1.9193500261098495 0.05456694943342438 0.13510424455785064 1.853611413796874e-07 6.7319813049983255 0.3219475889582918 ISHICFGMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISHICFGMK 9 0 O14802 O14802 POLR3A DNA-directed RNA polymerase III subunit RPC1 0 4228000.0 1222800.0 1259200.0 1746000.0 False True 1603102.6416120452 1071332.268323156 1565340.6688146375 1.0 0.6682867587604044 0.9764444447802574 20.612435368992568 -10.474629172564583 8.519609135870247 1.0000059370809278 0.8223656021679498 0.3070204401946486 0.12580484851090482 1.4187558981552472e-05 8.748456408664347e-07 0.12181409054294409 0.04060334026290677 3.352515754685139e-11 10.474629172564583 -0.17764033491297793 ISHICFGMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISHICFGMK 9 0 O14802 O14802 POLR3A DNA-directed RNA polymerase III subunit RPC1 0 4126300.0 1222800.0 1130500.0 1773000.0 False True 1674902.204927485 1080550.771936425 1354253.9160812031 1.0 0.6451426051965867 0.808557008341771 20.67564543051546 -10.102355001862726 4.959932841303629 1.0000096414555641 0.7268498067679756 0.7883731638581548 0.0667136507253608 7.112994666224582e-06 1.2873164349558026e-06 0.0645974940743518 0.021531738184739645 7.900325739820185e-11 10.102355001862726 -0.27315983468758853 ISHLFFHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISHLFFHK 8 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1;H3BQD1;H3BUV0;H3BTM1;H3BRA2 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 15624600.0 3942800.0 4426000.0 7255800.0 False True 5169048.982129514 3765658.0524128717 6505039.418548249 1.0 0.7285011353987051 1.2584596201424156 22.301467442712955 -6.767431590606708 1.5840949986600779 0.8437655354865149 1.2611685794149046 0.7207044517612626 0.11435154706421294 0.2706054991469822 1.3396881082357321 0.05691104504558648 0.13580408705198663 1.7083167902789635e-07 6.767431590606708 0.41740304392838967 ISHLFFHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISHLFFHK 8 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1;H3BQD1;H3BUV0;H3BTM1;H3BRA2 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 14634700.0 4355100.0 2348300.0 7931300.0 False True 4216849.7343612155 3285988.4362227223 5853854.596100217 1.0 0.779251963722273 1.388205642804813 22.00773418203574 -6.808640196312381 1.4203464603481588 0.8795007836384346 1.3985205106540897 0.8562239227601696 0.0954459961356479 0.208659575371259 0.8299188261201194 0.052844218952566 0.12231065628599752 1.553673662294792e-07 6.808640196312381 0.519019727015655 ISHLFFHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISHLFFHK 8 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1;H3BQD1;H3BUV0;H3BTM1;H3BRA2 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 15190800.0 3942800.0 4453000.0 6795000.0 False True 5400559.710163629 4256251.735898187 5190160.947417808 1.0 0.7881130779626598 0.9610413042281786 22.364677504235846 -10.004995511934606 5.669074854321809 1.0000002868280393 0.874577191154724 0.41224552491166155 0.0705976527460663 2.558939312706571e-07 4.4918558612749634e-08 0.0683560391840114 0.022785294447205375 9.885633105681329e-11 10.004995511934606 -0.12542309567331533 ISHLFFHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISHLFFHK 8 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1;H3BQD1;H3BUV0;H3BTM1;H3BRA2 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 12198600.0 4355100.0 4008600.0 3834900.0 False True 3621458.613642934 3987004.8761552027 4636759.859425784 1.0 1.1009389589971195 1.2803569926100933 21.788139457470017 -6.962284307439894 0.4019485786687442 0.9903466541450822 1.3975211863407644 0.9998457562145874 0.0014399090795169862 0.07889502205538232 0.018188951415469567 0.0023081836707173594 0.01502151244692384 1.0907260675051861e-07 6.962284307439894 0.4071745321956822 ISIEMNGTLEDQLSHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISIEMNGTLEDQLSHLK 17 0 O43707;O43707-2;O43707-3;F5GXS2;H7C144 O43707 ACTN4 Alpha-actinin-4 0 29654000.0 10143000.0 0.0 19511000.0 False True 15387672.552627021 0.0 15654642.298024895 1.0 0.0 1.0173495858119423 23.875271698950417 -12.075271949238752 18.19107419072657 0.8839590765233069 0.5578073136153849 0.0 0.48917020587604265 0.0 0.0 0.0 0.14068718738929512 8.408684364905486e-13 12.075271949238752 -0.3261517629079219 ISIEMNGTLEDQLSHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISIEMNGTLEDQLSHLK 17 0 O43707;O43707-2;O43707-3;F5GXS2;H7C144 O43707 ACTN4 Alpha-actinin-4 0 10648300.0 5839600.0 2138500.0 2670200.0 False True 4855886.138143617 2126979.476040985 3228526.474390138 1.0 0.43802087106888377 0.6648686527119413 22.211303162692598 -10.254212509545855 5.585995849979988 1.000030609067985 0.5514447618904028 0.8390514509563624 0.09261021905134478 3.530532151597081e-05 4.713631294351619e-06 0.089675563488449 0.02988981967286644 5.5691317276411185e-11 10.254212509545855 -0.4485858471775821 ISIIINSSAPPHTILNELKPEQVEQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISIIINSSAPPHTILNELKPEQVEQLK 27 1 E9PIN3;Q9UBU9;Q9UBU9-2;B4E227 E9PIN3 NXF1 Nuclear RNA export factor 1 0 46283000.0 15080000.0 16246000.0 14957000.0 False True 22877462.495673425 13346774.369422628 12000742.394114004 1.0 0.5834027428499451 0.524566148731905 24.44742370549191 -13.999999999999998 0.27573142441418397 4.316723007565413 0.5060958447751813 0.9995957746141015 0.0042547189288051285 15.171915602842752 0.16628248649759705 28.304442105057174 0.023755668919150028 1.0000000000000041e-14 13.999999999999998 -3.8106271627902313 ISIIINSSAPPHTILNELKPEQVEQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISIIINSSAPPHTILNELKPEQVEQLK 27 1 E9PIN3;Q9UBU9;Q9UBU9-2;B4E227 E9PIN3 NXF1 Nuclear RNA export factor 1 0 36594900.0 15080000.0 13451000.0 8063900.0 False True 19521357.27124021 12702440.025620708 6596352.942601219 1.0 0.6506945111001348 0.33790442185694125 24.21855002758436 -7.453824567387488 0.2491532908274954 1.1303201507842247 3.576086933153036e-11 0.9998894055528819 0.0028440084312633257 0.12314172346693726 0.022447880812548567 0.02397078360205308 0.061237829134203725 3.5170248153407126e-08 7.453824567387488 -1.1303201507484637 down ISINQALQHAFIQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISINQALQHAFIQEK 15 0 H0YDJ3;Q13523 H0YDJ3 PRPF4B Serine/threonine-protein kinase PRP4 homolog 0 9243900.0 2836700.0 3526000.0 2881200.0 False True 3718941.170641873 2999934.544240347 2583081.0624219514 1.0 0.8066636191834601 0.6945743274492624 21.826460495683722 -13.999999999995966 0.060524421451017656 2.223377209372711 0.19441120799445344 0.9999528495436888 0.0008662150404657371 12.458646332218482 0.06310370961627074 2.3015787580714897 0.4683972678933028 1.0000000000092888e-14 13.999999999995966 -2.0289660013782576 ISINQALQHAFIQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISINQALQHAFIQEK 15 0 H0YDJ3;Q13523 H0YDJ3 PRPF4B Serine/threonine-protein kinase PRP4 homolog 0 10165100.0 2836700.0 3832200.0 3496200.0 False True 3885504.648935059 3662880.732609265 2670469.566499212 1.0 0.9427039892007822 0.6872902770123143 21.889670557206614 -6.942394626102941 0.6368989639540409 1.0027910213507456 0.6132741945828408 0.998460996315101 0.0053327688634264405 0.08669106030990469 0.04976141785504121 0.005290574347327746 0.021761630449257958 1.141840318427637e-07 6.942394626102941 -0.3895168267679048 ISINQALQHAFIQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISINQALQHAFIQEK 15 0 H0YDJ3;Q13523 H0YDJ3 PRPF4B Serine/threonine-protein kinase PRP4 homolog 0 6859200.0 3388200.0 2101000.0 1370000.0 False True 2817438.4227101514 2089681.4959841545 1656460.6658357002 1.0 0.7416955341916744 0.5879314530829451 21.42595264885335 -11.314610880368084 0.07448061799797209 2.0551820448292126 9.545649712149706e-20 0.9999562308520439 0.0011248162202339151 4.054174092797378 0.04920257072653219 1.1093338854370065 0.3927767077234506 4.846063712575918e-12 11.314610880368084 -2.0551820448292126 ISIPDVDLDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISIPDVDLDLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 17388800.0 8517600.0 4788600.0 4082600.0 False True 7082761.793659173 4762802.861337325 4936252.784190392 1.0 0.6724499566823232 0.696938980583755 22.755880591933007 -10.714485981319749 6.769208999128512 1.0036815230529166 0.6846944686330417 0.9954961825608767 0.009997602142888222 0.0005601155183309948 2.36247068663856e-05 0.009761036634719871 0.003226712216784467 1.9298076278387045e-11 10.714485981319749 -0.31898705441987485 ISIPDVDLDLKGPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISIPDVDLDLKGPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 8756200.0 3093000.0 3497800.0 2165400.0 False True 4054952.9526546043 2975941.8743176106 1941345.179983515 1.0 0.7339029352657196 0.47875898996869976 21.951253745082223 -6.971637013813983 0.2155304989543851 1.124508113588595 0.08098633154809198 0.9999924900861901 0.0005831645363588606 0.07577503109702158 0.007097809706185439 0.007315347175729086 0.0261110364653864 1.0674879619387773e-07 6.971637013813983 -1.0435217820405032 down ISIPDVDLDLKGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISIPDVDLDLKGPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 6087100.0 1724100.0 1666300.0 2696700.0 False True 1669369.3892246247 2331662.2796397083 1990353.3707341128 1.0 1.3967323797177689 1.1922785835066594 20.670871791273193 -10.16340077053779 4.435564787872845 0.9999426806578642 1.2945054816212125 0.734503532592598 0.08346791281252537 9308467.918980416 21467070.291054886 3079.0374589763474 0.028573289332653695 6.864347000336816e-11 10.16340077053779 0.2945628009633483 ISIPDVDLDLKGPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISIPDVDLDLKGPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 33852600.0 3134000.0 21332000.0 9386600.0 False True 4754507.126090217 17525137.932323277 7531334.395707068 1.0 3.6860051878258 1.5840410364260669 22.180864361808464 -6.5845793549611455 2.250114109480613 2.8240522735570956 1.589751413784639 0.0 1.1655394233666796 0.6854663511902274 6.534879249973983 0.4338543797638514 1.3005831685838483 2.6026792223403046e-07 6.5845793549611455 -1.2343008597724567 ISIPDVDLDLKGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISIPDVDLDLKGPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 14377800.0 3093000.0 7920000.0 3364800.0 False True 4236565.685182127 7570068.212062356 2570103.5402312647 1.0 1.7868407513518638 0.6066478679229489 22.014463806605114 -6.726981733693906 1.7340040479675214 1.4750977097376068 0.6076995858550668 0.5453043175868426 0.33085561000933056 0.34193410180192585 2.012701775709425 0.15128518522236817 0.3767266656145013 1.8750733714776224e-07 6.726981733693906 -0.86739812388254 ISIPDVDLDLKGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISIPDVDLDLKGPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5146700.0 1724100.0 2380600.0 1042000.0 False True 1433665.5405804173 2367775.235287897 1259877.382336351 1.0 1.6515534260029063 0.878780543073032 20.45127706670747 -6.683202445004025 1.890880979929743 1.4110603334246117 0.8816696809842961 0.3387153452184547 0.2759531797727019 0.4314244376740668 2.9851165187365654 0.1169958844094709 0.3072666508950871 2.073946528454952e-07 6.683202445004025 -0.5293906524403156 ISIPDVDLDLKGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISIPDVDLDLKGPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 10825700.0 3134000.0 4473000.0 3218700.0 False True 4057024.7803757815 4224073.617916987 2632929.62665094 1.0 1.0411752075928244 0.6489804152507703 21.951990683900913 -6.880961269249761 1.0743929412232145 1.025860785288721 0.6206648855397503 0.9744538840062079 0.02812746674625401 0.1267833521878409 0.26715291101603983 0.02014875894415657 0.048847303853320846 1.3153421302885624e-07 6.880961269249761 -0.40519589974897063 ISIPDVGLHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISIPDVGLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 127109100.0 37979900.0 40711700.0 48417500.0 False True 49792016.69787477 34637673.05296369 43407721.55345511 1.0 0.6956471207650864 0.8717807478424114 25.569411113459676 -10.204068137963624 5.270717010491495 1.000013800551294 0.7837139349827517 0.6678329321560484 0.07190625214773083 1.1661678971047666e-05 1.7611121294069509e-06 0.06962736991857879 0.02320764308799863 6.250746149633364e-11 10.204068137963624 -0.2162998655685423 ISIPDVGLHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISIPDVGLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 147207600.0 47569200.0 35223200.0 64415200.0 False True 46059141.78406366 49288007.446561374 47542926.70542221 1.0 1.0701026015125383 1.0322147756967528 25.456984193982972 -10.087949627543386 3.8823076877791793 0.9999856722894201 1.0511586886204116 0.7085365235259569 0.015467640284032852 5376984.162239229 0.0055326998819153535 707.783058049443 0.005294984669883967 8.166770896829971e-11 10.087949627543386 0.05117301633099147 ISIPDVGLHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISIPDVGLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 99092200.0 28439200.0 43610000.0 27043000.0 False True 43144345.584015615 35827454.773514785 21697939.196632016 1.0 0.8304090440715448 0.5029150147701117 25.36266815913289 -6.960725278431762 0.42509486687390835 1.0137059837178874 0.3071604710700149 0.9997961444112742 0.0029457725940049296 0.07944312945674951 0.02018204932779027 0.004251999938981194 0.02722453424478216 1.0946485889350016e-07 6.960725278431762 -0.7065455126478726 ISIPDVGLHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISIPDVGLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 146281100.0 37979900.0 41756500.0 66544700.0 False True 52022095.39820521 39911559.75971989 50828212.39111612 1.0 0.7672040015730865 0.9770504629244464 25.632621174982567 -10.336413530861627 7.241890851564167 1.000002000586285 0.8721272323072061 0.33114772402213455 0.08566945910658377 2.767248937842998e-06 2.5346607779684806e-07 0.08295039486511163 0.027649699033199675 4.6087852164429386e-11 10.336413530861627 -0.12787476827907895 ISIPDVGLHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISIPDVGLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 94296300.0 47569200.0 20731500.0 25995600.0 False True 39555897.472871706 20619815.294619422 31431159.76992593 1.0 0.5212829593554523 0.7946011031978759 25.23738946941725 -10.188562794725252 5.550115123796858 1.0000107282727777 0.6579420312766368 0.676201468529972 0.11158166497652522 1.481290256891391e-05 2.1654773566264265e-06 0.1080418693876119 0.036012827516333674 6.477944237727725e-11 10.188562794725252 -0.34206869699614095 ISIPDVGLHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISIPDVGLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 79746200.0 28439200.0 32979000.0 18328000.0 False True 36815105.02044127 31143689.65912913 14992492.061160866 1.0 0.8459486844282222 0.4072375198396531 25.13379448122534 -6.952614777270497 0.5293600142390633 1.0069510782501188 0.22634115861533768 0.999390828183651 0.006198075940406711 0.08245246325727851 0.031746184140039865 0.00692142180755762 0.036276091813741085 1.1152833603687515e-07 6.952614777270497 -0.7806099196347811 down ISITEGIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISITEGIER 9 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 10400600.0 1811100.0 2507700.0 6081800.0 False True 2374369.6387173487 2133560.934938041 5452513.676745047 1.0 0.8985799431341305 2.2964047332118573 21.179113118639478 -6.889455393081251 1.0256223424403432 0.9239094191477777 2.41534527232638 0.9805465737959477 0.08876005099014246 0.11958519451308836 0.2244491831244113 0.06598881684625808 0.1641883772775386 1.2898660348172135e-07 6.889455393081251 1.4914358531786023 up ISK(ub)EEAMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISKEEAMR 8 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 7114680.0 1739000.0 2579580.0 2796100.0 True False 1683796.3968804735 3609619.7463319874 2063717.5287980312 1.0 2.143738846941018 1.225633652988822 20.683286268910578 -10.25549406628482 4.140596122267847 0.9994466047588373 1.6846862500052862 0.42579695465316403 0.3748148760953086 267014538.14783263 228690144.68161657 1640185.9481667737 0.13716818803199435 5.5527220368750996e-11 10.25549406628482 0.6852396452464489 ISK(ub)EEAMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISKEEAMR 8 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 20622690.0 2843500.0 677290.0 17101900.0 True False 4313797.387695444 556422.307809077 13721701.968970956 1.0 0.1289866578797142 3.180886985584988 22.040526986288114 -6.830416776365176 1.3259230060432923 0.5347032826953293 3.2637816797540182 0.9067223844146074 0.3920340636196855 0.1803022676846448 0.6197728620439239 0.23212871036483998 0.5342221471410442 1.4776896233846454e-07 6.830416776365176 2.729078397058689 ISK(ub)EEAMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ISKEEAMR 8 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 13828280.0 3407100.0 6561700.0 3859480.0 True False 2833154.6101221167 6526350.81970453 4666479.423780702 1.0 2.3035632423262724 1.647096634651917 21.433977903539333 -10.296031133527148 6.78538306196413 0.999983690031167 1.9753299384890946 0.7463974659798999 0.2680013703296672 6.612645538756916e-05 6.860207135970876e-06 0.2594955325165443 0.08649707033729727 5.0578840194906265e-11 10.296031133527148 0.9753462484579275 ISK(ub)EEAMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ISKEEAMR 8 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 55769300.0 3890100.0 3126700.0 48752500.0 True False 5035811.135334975 2952696.3964098063 39880045.24289312 1.0 0.5863397806346439 7.919289300399936 22.26379274610131 -6.893541024961171 1.0012170596947227 0.6387826825770896 8.595503881559123 0.9830690943019171 0.4376581496230461 0.11631645371412387 0.20544947382991519 0.3314268861162366 0.837498249432024 1.2777884995370664e-07 6.893541024961171 7.9567211989820334 up ISK(ub)GANPVEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISKGANPVEIR 11 1 P10809;E7ESH4;E7EXB4;P10809-2 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 8810500.0 2453200.0 4423400.0 1933900.0 True False 2039944.4951869855 4399570.266223841 2338269.548656688 1.0 2.1567107715940907 1.1462417502895623 20.960098467791596 -6.613502749180764 2.1408359409671944 1.7709810813911637 1.149957652359976 0.06137694906086355 0.49825378925755115 0.6030561973328448 5.242616484615752 0.19185650822547085 0.5528483245357281 2.434990385871955e-07 6.613502749180764 -0.6210234290311878 ISK(ub)YSQTESQQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISKYSQTESQQIR 13 1 A0A2R8Y635;A0A2R8YDN7;Q9H7F0 A0A2R8Y635 ATP13A3 Probable cation-transporting ATPase 13A3 1 4895400.0 659400.0 1087900.0 3148100.0 True False 864479.785638683 925589.5606009857 2822364.8107075337 1.0 1.070689651715979 3.2648129633503844 19.721472703775984 -6.9137586743887125 0.8697405627472103 0.9398721826021306 3.5724095981302373 0.9922645108157642 0.09247036478148427 0.10198483671410523 0.1256709263953019 0.07714280201577091 0.21892718647684592 1.2196671464636692e-07 6.9137586743887125 2.6325374155281067 up ISK(ub)YSQTESQQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISKYSQTESQQIR 13 1 A0A2R8Y635;A0A2R8YDN7;Q9H7F0 A0A2R8Y635 ATP13A3 Probable cation-transporting ATPase 13A3 1 13453700.0 1320100.0 7647400.0 4486200.0 True False 2002688.2122372992 6282661.720591075 3599500.6036286848 1.0 3.137114245842797 1.7973344935243363 20.9335064025208 -10.377250377239081 6.04256200267394 0.9997467827940961 2.467224369683567 0.6152456318047947 0.546962793482112 0.0018661365316552819 0.00019232510526926672 0.5296792040900772 0.17653148251260836 4.195170564271509e-11 10.377250377239081 1.467477586889471 ISK(ub)YSQTESQQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISKYSQTESQQIR 13 1 A0A2R8Y635;A0A2R8YDN7;Q9H7F0 A0A2R8Y635 ATP13A3 Probable cation-transporting ATPase 13A3 1 5654790.0 659400.0 995290.0 4000100.0 True False 903197.9996149677 951314.7968161044 3055358.7646454717 1.0 1.0532738084247848 3.3828227763435788 19.784682765298875 -6.911827547936656 0.8831892248582438 0.931974225386502 3.6959584268424592 0.991593316940194 0.1018588735131939 0.10322212740994678 0.13230087687866274 0.08415414295687872 0.23535547306179902 1.2251025732221e-07 6.911827547936656 2.7639842014559575 up ISK(ub)YSQTESQQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISKYSQTESQQIR 13 1 A0A2R8Y635;A0A2R8YDN7;Q9H7F0 A0A2R8Y635 ATP13A3 Probable cation-transporting ATPase 13A3 1 10218100.0 1320100.0 4413800.0 4484200.0 True False 1708895.4730612854 4168168.149957978 3668121.6117774746 1.0 2.4391007031525427 2.1464868212252126 20.704632724613248 -10.12776769904395 4.833635302378392 0.9999213902521302 2.292793762196825 0.9629985902078108 0.1194591170902194 0.00010120377812601851 1.8262423546536702e-05 0.11567273387529284 0.03855526424969087 7.451304321727694e-11 10.12776769904395 1.2928723719446946 ISLCLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISLCLK 6 0 P53618 P53618 COPB1 Coatomer subunit beta 0 45855000.0 14348000.0 13150000.0 18357000.0 False True 18810366.94622963 11188071.258298531 16457593.732777951 1.0 0.5947821906016076 0.8749214611189033 24.165024656950482 -10.097471968490392 5.504150448330877 1.0000028565285666 0.7348518258601678 0.5443049828538149 0.11436637828078838 4.0089789590521345e-06 6.571488160795309e-07 0.11073596247828946 0.036911589870584495 7.989655091809569e-11 10.097471968490392 -0.26515103066839874 ISLCLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISLCLK 6 0 P53618 P53618 COPB1 Coatomer subunit beta 0 10493900.0 6816200.0 1566500.0 2111200.0 False True 6599823.461999248 2192011.619189584 1558213.3853576062 1.0 0.3321318565278063 0.23609925240115215 22.65399600380973 -13.999999999999998 0.27316395068983135 6.243549129290525 0.20518736438553611 0.9995901701806441 0.006877797183136853 15.040532466494504 0.16547967656481552 43.879815197173365 0.03926357049249499 1.0000000000000041e-14 13.999999999999998 -6.038361764904988 ISLCLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISLCLK 6 0 P53618 P53618 COPB1 Coatomer subunit beta 0 63054000.0 14348000.0 18964000.0 29742000.0 False True 19652843.34012064 18126107.774438217 22717552.155717503 1.0 0.9223147745463558 1.1559422604942033 24.228234718473374 -6.8170762399156875 1.384529163028214 0.9580000877234158 1.1607274249142892 0.8775084232148469 0.03399966581811554 0.19731301688502614 0.743992191862818 0.01930138423406051 0.044523864501690144 1.5237852315052586e-07 6.8170762399156875 0.20272733719087332 ISLEDIQAFEK(ub)TYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISLEDIQAFEKTYK 14 1 Q8WXX5 Q8WXX5 DNAJC9 DnaJ homolog subfamily C member 9 1 9610900.0 2626000.0 4343500.0 2641400.0 True False 2542639.0673997286 6077882.201053277 1949538.0996985512 1.0 2.3903833929795324 0.7667380418614735 21.27789525249688 -6.680038022214657 1.9021495620392823 1.879713182697533 0.7729792114821077 0.3240982683234901 0.589277838368457 0.4384528143877718 3.067290060872724 0.24860299865692914 0.655546355888496 2.0891132222702681e-07 6.680038022214657 -1.1067339712154254 ISLEVQLEQLRPFSHL ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISLEVQLEQLRPFSHL 16 1 E9PMG1;H0YDT0;Q96D71-2;Q96D71-4;Q96D71-3;Q96D71 E9PMG1 REPS1 RalBP1-associated Eps domain-containing protein 1 0 39451000.0 10967000.0 17433000.0 11051000.0 False True 16637740.795096166 14321944.94534932 8866765.006174637 1.0 0.8608106786692213 0.5329308296946206 23.987956210371376 -6.956723226493462 0.479387174546644 1.0079156068099557 0.37216985192239743 0.9996287056030746 0.0037728315901042696 0.08089308250126588 0.02561902682685958 0.004617280310149151 0.027047918427115923 1.1047824674449071e-07 6.956723226493462 -0.6357457548875582 ISLEVQLEQLRPFSHL ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISLEVQLEQLRPFSHL 16 1 E9PMG1;H0YDT0;Q96D71-2;Q96D71-4;Q96D71-3;Q96D71 E9PMG1 REPS1 RalBP1-associated Eps domain-containing protein 1 0 28334600.0 10967000.0 6799600.0 10568000.0 False True 14196997.691889333 6421196.282671216 8644732.436836977 1.0 0.4522925495958635 0.6089127169313879 23.759082532463825 -10.700316752692677 10.273047120126968 1.0003916341261188 0.5306026332636757 0.9229367573647951 0.063939915566892 0.0005739564471923084 1.674327265982883e-05 0.06195589156460648 0.02063651901237343 1.993807600905302e-11 10.700316752692677 -0.469789000862443 ISLFEGANFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISLFEGANFK 10 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 16231900.0 4598700.0 5253300.0 6379900.0 False True 6028940.233874146 4469528.117203011 5719769.148322165 1.0 0.7413455671845216 0.948718833898058 22.52347299703776 -9.937713884513515 5.801163373816558 1.0000001065972528 0.845032200805987 0.42679881682006815 0.08465978162407117 1.1670567408534027e-07 2.1371471996043898e-08 0.08197153726823178 0.027323827026912356 1.1542134092560368e-10 9.937713884513515 -0.15496790579126585 ISLFEGANFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISLFEGANFK 10 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 17554600.0 6120400.0 2619700.0 8814500.0 False True 5926111.252137579 3665759.8715550234 6505718.020668162 1.0 0.6185776330528329 1.097805583437455 22.498654279896165 -6.694667220216996 1.8499156248588413 0.7619276883709537 1.0962460799320815 0.3923523960399068 0.1611649006403905 0.40669330562483746 2.7019154738725977 0.06960424263281334 0.18018961937359004 2.0199135372001878e-07 6.694667220216996 0.33431839156112775 ISLFEGANFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISLFEGANFK 10 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 22593700.0 4598700.0 10799000.0 7196000.0 False True 6298963.66519465 10321864.472482491 5496453.0062720515 1.0 1.6386607418481633 0.8725963981413442 22.586683058560652 -6.685453091768824 1.882285791866877 1.402095902613646 0.8753625321334418 0.3492716479111211 0.2703638113814437 0.42656760642514585 2.92642403566803 0.11505376849411504 0.3013683063635368 2.0632265047708566e-07 6.685453091768824 -0.5267333704802041 ISLFEGANFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISLFEGANFK 10 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 11417900.0 6120400.0 2353600.0 2943900.0 False True 5089383.77969282 2340920.68964698 3559455.8789443206 1.0 0.4599615181286782 0.6993883804060771 22.27905955533044 -10.34807105895681 5.862260311620472 1.000063358971239 0.5796749492673793 0.8042769092662214 0.09774560721587783 8.095383473625338e-05 9.00259719164671e-06 0.09465597340751876 0.031547259076001755 4.48671972535358e-11 10.34807105895681 -0.4203884097038598 ISLGLPVGAVINCADNTGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISLGLPVGAVINCADNTGAK 20 0 P62829;C9JD32;J3KT29;B9ZVP7 P62829 RPL23 60S ribosomal protein L23 0 91555000.0 28195000.0 42224000.0 21136000.0 False True 36963918.04076843 35924343.78786287 18949049.47082828 1.0 0.971875972353391 0.51263638908432 25.139614349493694 -6.919422661976759 0.8289984938903092 1.0103453018379944 0.43955472586475913 0.9940189890523458 0.017277991781756822 0.09851278312576738 0.10738376419501229 0.014841402014289597 0.044214564455164904 1.2038637516062375e-07 6.919422661976759 -0.5707905759732352 ISLGLPVGAVINCADNTGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISLGLPVGAVINCADNTGAK 20 0 P62829;C9JD32;J3KT29;B9ZVP7 P62829 RPL23 60S ribosomal protein L23 0 70049000.0 34156000.0 22236000.0 13657000.0 False True 33071736.476049136 31114950.759208094 10079821.998782132 1.0 0.9408320842705624 0.3047865964365685 24.979095462374794 -6.925043928548351 0.7864145500201059 1.011651669173997 0.18929437710291058 0.9954711228149645 0.021178956689467038 0.09529428224067542 0.09089634360089834 0.018753579993657926 0.0591967693089555 1.1883820174427207e-07 6.925043928548351 -0.8223572920710864 down ISLGLPVGAVINCADNTGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISLGLPVGAVINCADNTGAK 20 0 P62829;C9JD32;J3KT29;B9ZVP7 P62829 RPL23 60S ribosomal protein L23 0 79892000.0 10557000.0 56984000.0 12351000.0 False True 16015740.820081169 46814759.98197586 9909819.436364397 1.0 2.923046801761281 0.6187549828440702 23.932987196806703 -6.685258495269751 1.8833553603743503 2.2109415244502393 0.6271594386083088 0.3483163412269932 0.8141118066448616 0.42692564314042186 2.9321507854876603 0.3463025240259269 0.907192318678271 2.0641511921318545e-07 6.685258495269751 -1.5837820858419305 ISLGLPVGAVINCADNTGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISLGLPVGAVINCADNTGAK 20 0 P62829;C9JD32;J3KT29;B9ZVP7 P62829 RPL23 60S ribosomal protein L23 0 161891000.0 28195000.0 56678000.0 77018000.0 False True 38619453.44122544 54173778.5509179 58827934.6355004 1.0 1.4027588099703283 1.5232720661111905 25.202824411016586 -12.078836058704397 0.19934406197362886 4.107543237313511e-08 1.6102804808024753 0.9994098726210772 0.005435302596461833 5.456887872379895 0.1258986187755834 2.318142895482398 0.07663604349395964 8.339959493220794e-13 12.078836058704397 1.610280439727043 ISLGLPVGAVINCADNTGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISLGLPVGAVINCADNTGAK 20 0 P62829;C9JD32;J3KT29;B9ZVP7 P62829 RPL23 60S ribosomal protein L23 0 57176100.0 34156000.0 6905100.0 16115000.0 False True 28402227.367359642 6867900.85574497 19484571.992658634 1.0 0.2418085302576546 0.6860226749346658 24.75950073780907 -10.12175899099152 6.502502870584009 1.000001043442422 0.46391560260282516 0.6600802316677026 0.18134966516426046 2.7431210955942622e-06 3.7100055620204555e-07 0.1755913983584566 0.05853035275178882 7.555113776695851e-11 10.12175899099152 -0.5360854408395969 ISLGLPVGAVINCADNTGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISLGLPVGAVINCADNTGAK 20 0 P62829;C9JD32;J3KT29;B9ZVP7 P62829 RPL23 60S ribosomal protein L23 0 38352000.0 10557000.0 17065000.0 10730000.0 False True 13666244.609581076 16115317.748659395 8777250.09909735 1.0 1.1792060078714919 0.6422576464747186 23.704113518899153 -6.8167276038375375 1.3859780759302447 1.0969247149172863 0.6313398218928657 0.8766738340188901 0.07838681170232882 0.1977799859670282 0.7473934862393261 0.04445341138689837 0.10255783829012931 1.5250089629112945e-07 6.8167276038375375 -0.4655848930244205 ISLGMPVGPNAHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISLGMPVGPNAHK 13 0 Q13435;E9PPJ0;H0YEX5 Q13435 SF3B2 Splicing factor 3B subunit 2 0 12741400.0 1669100.0 3449000.0 7623300.0 False True 2188206.263587392 2934422.6440967023 6834514.043857172 1.0 1.3410173862156611 3.1233408648837906 21.06131730445156 -6.93882178132454 0.6704335783304114 0.979528324967332 3.5877655217049016 0.9980054898298418 0.04158026117800011 0.08830825396871185 0.057088087249906015 0.04012272481366133 0.15421437405124644 1.151272732519887e-07 6.93882178132454 2.6082371967375697 up ISLGMPVGPNAHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISLGMPVGPNAHK 13 0 Q13435;E9PPJ0;H0YEX5 Q13435 SF3B2 Splicing factor 3B subunit 2 0 10810100.0 1669100.0 4053100.0 5087900.0 False True 2286211.3757314878 3874020.640190646 3886242.80858971 1.0 1.6945155121324373 1.699861548167777 21.12452736597445 -11.197877954473661 0.7867557868011597 1.2897991284536236e-05 1.6987383246740273 0.9999923649574256 0.0009081351957173642 3.94806980446262 0.4178800360395609 6.96305563752961 0.0007785667633246699 6.340478664874904e-12 11.197877954473661 1.6987254266827427 ISLIQIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISLIQIFR 8 0 Q6P2Q9;I3L3Z8 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 34367700.0 7379200.0 9352500.0 17636000.0 False True 9674202.660274463 7957143.455759476 15811195.896457583 1.0 0.8225115531674966 1.6343668260521027 23.20571132975737 -6.849437262777014 1.237931761636672 0.9053348268356258 1.666447425890753 0.939463406557448 0.08574410113169012 0.1580796885827524 0.46648053277008195 0.05420900616299652 0.12538892464841492 1.4143690269434315e-07 6.849437262777014 0.7611125990551271 ISLIQIFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISLIQIFR 8 0 Q6P2Q9;I3L3Z8 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 16406300.0 6429400.0 3691900.0 6285000.0 False True 6225302.216275623 5166094.923004165 4638769.954041572 1.0 0.829854478309144 0.7451477523314175 22.56971244591673 -13.999999999987855 0.09075156098571477 1.8684216252436072 0.5357653934809312 0.9998388735556298 0.001345174838361957 12.157025883435166 0.08771236762788356 2.031549452571097 0.18799921458164698 1.0000000000279648e-14 13.999999999987855 -1.332656231762676 ISLIQIFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISLIQIFR 8 0 Q6P2Q9;I3L3Z8 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 34060200.0 7379200.0 10580000.0 16101000.0 False True 10107489.655381834 10112540.61661865 12298275.410503926 1.0 1.000499724601165 1.2167487506609107 23.268921391280262 -6.90740436892523 0.9132246762987791 0.9927425398803491 1.2431980071754807 0.9899047373032573 0.010254370992007916 0.10615970562616883 0.14826121495678832 0.008289100387953902 0.02249048218226851 1.2376436874476434e-07 6.90740436892523 0.2504554672951316 ISLIQIFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISLIQIFR 8 0 Q6P2Q9;I3L3Z8 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 13283400.0 6429400.0 2683900.0 4170100.0 False True 5346330.970713842 2669441.2979875626 5042048.629636096 1.0 0.49930341249171467 0.943085764284975 22.350117721351005 -10.30843655068739 8.315782979930406 1.0000004947771535 0.721194588388345 0.34480401135808714 0.1811733864576312 1.6618131700174745e-06 1.383092481467987e-07 0.1754206881782895 0.058473459043867165 4.9154518844799324e-11 10.30843655068739 -0.2788059063888084 ISLLK(ub)LTQGETLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISLLKLTQGETLR 13 1 A0A0A0MTI1;Q15392;Q15392-2 A0A0A0MTI1 DHCR24 Delta(24)-sterol reductase 1 10130500.0 1395400.0 0.0 8735100.0 True False 1829382.9130728203 0.0 7831275.644995839 1.0 0.0 4.280829119498892 20.802925650409843 -6.845159887338785 1.258164444566044 0.46781714624667253 4.436685505068298 0.9329736719907904 0.47337767578836837 0.1628580895719903 0.49852891039780667 0.29473919157330747 0.6802839865891199 1.4283680020173438e-07 6.845159887338785 3.9688683588216254 ISLLK(ub)LTQGETLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISLLKLTQGETLR 13 1 A0A0A0MTI1;Q15392;Q15392-2 A0A0A0MTI1 DHCR24 Delta(24)-sterol reductase 1 48739400.0 1957300.0 4006100.0 42776000.0 True False 1895166.582871853 5605756.621535516 31571682.347507127 1.0 2.9579228930054247 16.65905394958198 20.853893234459605 -6.932673888914626 0.7245084810807938 0.8109142193184851 19.673440664392615 0.9970381546987322 0.37912425578378356 0.09127300758578355 0.07105168044889869 0.3510669466906185 1.2219996602719463 1.1676861017143516e-07 6.932673888914626 18.86252644507413 ISLLK(ub)LTQGETLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISLLKLTQGETLR 13 1 A0A0A0MTI1;Q15392;Q15392-2 A0A0A0MTI1 DHCR24 Delta(24)-sterol reductase 1 99524600.0 2455600.0 45475000.0 51594000.0 True False 3725324.728406871 37359630.95220329 41396423.28554643 1.0 10.028556884537705 11.112165060373016 21.828934756950858 -9.46823964257024 0.6429445427802998 1.3757329642940105e-12 10.974339091813217 0.998825398974185 0.15536212258457974 0.8013925240292461 0.2971159906202116 2.3183068347462306 0.17774817008764401 3.40220405157899e-10 9.46823964257024 10.974339091811842 ISLLK(ub)LTQGETLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISLLKLTQGETLR 13 1 A0A0A0MTI1;Q15392;Q15392-2 A0A0A0MTI1 DHCR24 Delta(24)-sterol reductase 1 18326000.0 1395400.0 2094600.0 14836000.0 True False 1911317.0892670993 2002053.6460840667 11332042.357011126 1.0 1.0474733142535553 5.92891803282962 20.866135711932735 -6.909028362226075 0.9023307575691952 0.8441772903848508 6.546815888067045 0.9905495983066837 0.2247963224830066 0.10506391724818134 0.14228017936539075 0.1831641458330276 0.5022730712410404 1.233024306172877e-07 6.909028362226075 5.702638597682195 up ISLLK(ub)LTQGETLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISLLKLTQGETLR 13 1 A0A0A0MTI1;Q15392;Q15392-2 A0A0A0MTI1 DHCR24 Delta(24)-sterol reductase 1 23725700.0 1957300.0 5818400.0 15950000.0 True False 1627581.6730920793 5787055.124338025 19285071.25553243 1.0 3.5556158071894353 11.848911531975322 20.63429850989388 -6.949672808057929 0.5624240040100008 0.8928796639879296 14.909650398540208 0.9991753578806143 0.1329842061749104 0.0836173874275472 0.036508124929776835 0.1421377257471593 0.6897665750097426 1.1228640872472993e-07 6.949672808057929 14.016770734552278 ISLLK(ub)LTQGETLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISLLKLTQGETLR 13 1 A0A0A0MTI1;Q15392;Q15392-2 A0A0A0MTI1 DHCR24 Delta(24)-sterol reductase 1 67661600.0 2455600.0 30638000.0 34568000.0 True False 3178822.607112561 28932968.367033508 28276978.697632506 1.0 9.10178765631542 8.895425191189736 21.600061079043307 -9.871478251233489 8.03876052947041 0.9999999951923817 8.998606423752578 0.9995010267437493 0.084247123603472 1.083580832736378e-08 1.2096555691988092e-09 0.08157192667052864 0.027190642223510017 1.34437908931996e-10 9.871478251233489 7.998606428560197 ISLLLHLLEDELDHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISLLLHLLEDELDHR 15 0 C9J0I9;Q86WB0-3;Q86WB0-2;Q86WB0 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 0 41995000.0 13457000.0 15594000.0 12944000.0 False True 20415252.838479906 12811128.863521889 10385612.726443257 1.0 0.6275273181713771 0.508718300410555 24.283144099350515 -13.999999999999998 0.15988304689676622 2.8339229075447245 0.39177233296849395 0.9995366750899234 0.004504894098355329 12.008927261350626 0.12635600045687964 6.829715173777698 0.10657030778933861 1.0000000000000041e-14 13.999999999999998 -2.4421505745762304 ISLLLHLLEDELDHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISLLLHLLEDELDHR 15 0 C9J0I9;Q86WB0-3;Q86WB0-2;Q86WB0 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 0 29076300.0 13457000.0 11487000.0 4132300.0 False True 17420351.777127273 10847738.352115456 3380263.80097856 1.0 0.6227048966002177 0.19404107587636713 24.054270421442965 -7.524904742122322 0.3911652408021381 1.0419743625518323 6.176971224239734e-22 0.9989534848780439 0.010651329345981448 0.12026694347463616 0.04826125850776958 0.020452009088462217 0.06765585797874578 2.9860375026764786e-08 7.524904742122322 -1.0419743625518323 down ISLNSLCYGDMDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISLNSLCYGDMDK 13 0 O75131;A0A087WYQ3;H0YB26 O75131 CPNE3 Copine-3 0 18864400.0 3025300.0 8288600.0 7550500.0 False True 3966197.597046873 7051973.188709744 6769246.689510262 1.0 1.778018622662789 1.7067346050914018 21.919325124142148 -10.181039077442184 4.297010848986096 0.999776618357629 1.7423766139161987 0.9931324123189498 0.02910157844912388 10209875.368588913 9.618246101778155 22695.629629652285 0.009962244339239154 6.591145860151916e-11 10.181039077442184 0.7425999955585697 ISLNSLCYGDMDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISLNSLCYGDMDK 13 0 O75131;A0A087WYQ3;H0YB26 O75131 CPNE3 Copine-3 0 15022300.0 3025300.0 5457900.0 6539100.0 False True 4143835.16565842 5216751.931138279 4994699.256991875 1.0 1.2589187847942263 1.205332513799028 21.98253518566504 -10.042375915058978 4.4837534089698465 0.9999883553068801 1.232125649278354 0.9615672238094843 0.021876503592254168 11445562.691431198 0.4774254709535487 1394.6674269370158 0.00800598053380217 9.070350821235048e-11 10.042375915058978 0.23213729397147398 ISLPLPNFSSLNLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISLPLPNFSSLNLR 14 0 B0YJC4;P08670 B0YJC4 VIM Vimentin 0 16676400.0 4088900.0 6234900.0 6352600.0 False True 6203160.238631234 5122233.381503951 5097005.8255565055 1.0 0.8257457786765482 0.8216788909972108 22.56457196208694 ISLPLPNFSSLNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISLPLPNFSSLNLR 14 0 B0YJC4;P08670 B0YJC4 VIM Vimentin 0 15248900.0 4088900.0 6973000.0 4187000.0 False True 5293161.654268835 6584946.420240364 3425008.962247958 1.0 1.244047858415533 0.6470629816275785 22.33569828417939 -6.795725473960289 1.473465192382332 1.135390238698993 0.6396809261896998 0.8193202814859155 0.10416870331997344 0.22691894583814798 0.973047144895072 0.05563071367147725 0.12971854088544316 1.6005694601817558e-07 6.795725473960289 -0.49570931250929307 ISLQAIQQLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISLQAIQQLVR 11 0 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 0 8513800.0 1577200.0 2877400.0 4059200.0 False True 2067724.4736265242 2448103.136017355 3639192.922595865 1.0 1.1839600329939972 1.7599989597323797 20.979612527213412 -6.950483586332 0.5535086726873901 0.9921942694003337 1.9789895865575884 0.9992386918130381 0.008932535320119167 0.08329213051592566 0.03516314243059866 0.009652035474038468 0.047819808590410705 1.1207697835606439e-07 6.950483586332 0.9867953171572547 ISLQAIQQLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISLQAIQQLVR 11 0 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 0 8138300.0 2751900.0 2350000.0 3036400.0 False True 2664542.4408139046 3288367.255088103 2241075.7499525547 1.0 1.2341208024007477 0.8410733924238044 21.345456381841945 -6.745377772980054 1.6671123593875894 1.1384303031997995 0.8405679561293768 0.6287425628862543 0.09836487551931711 0.3081953842161481 1.6837799654817773 0.04664125584702916 0.11378020190264057 1.7973068396475501e-07 6.745377772980054 -0.2978623470704227 ISLQAIQQLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISLQAIQQLVR 11 0 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 0 13514300.0 1577200.0 5092400.0 6844700.0 False True 2160333.462227368 4867400.929685142 5228122.831021442 1.0 2.253078524584213 2.4200536271058324 21.042822588736303 -10.61063412378517 0.40055282858451763 3.3543627867445776e-25 2.434408932946812 0.9993517088583492 0.016136012173983215 2.130050435618281 0.1913528294522109 2.166036510834833 0.0424926653324196 2.4511273517459737e-11 10.61063412378517 2.434408932946812 ISLQAIQQLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISLQAIQQLVR 11 0 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 0 7168900.0 2751900.0 1677500.0 2739500.0 False True 2288326.779840646 1668462.974542319 3312316.7839831403 1.0 0.7291191927835181 1.4474841675426282 21.12586165727622 -6.804527462491017 1.4371891555107388 0.8513912069277518 1.4585658528933885 0.8451246470802574 0.1165713482382579 0.2143505701321334 0.8735249372199139 0.06379383758987937 0.14798237433013023 1.5684567136194533e-07 6.804527462491017 0.6071746459656366 ISLQLHLALTSNSSWVQCPSHLELMNQCR ddPTM_RPMI8226_Bortezomib_8h_R1 2 ISLQLHLALTSNSSWVQCPSHLELMNQCR 29 0 A0A494C1B8;A0A494C0U1;Q5VZU9;P29144 A0A494C1B8 TPP2 Tripeptidyl-peptidase 2 0 182310000.0 48213000.0 62160000.0 71937000.0 False True 73142645.84243385 51067062.34170328 57718620.41889288 1.0 0.6981845099193366 0.7891240432186732 26.124209479497836 -10.318991908882982 8.089249693448645 1.000000794294553 0.743654276569005 0.9137531123014333 0.03712590900503574 5.318145525070558e-07 4.4763494092682326e-08 0.035947117694672494 0.011982335607442945 4.7974238638697216e-11 10.318991908882982 -0.25634651772554806 ISLQLHLALTSNSSWVQCPSHLELMNQCR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ISLQLHLALTSNSSWVQCPSHLELMNQCR 29 0 A0A494C1B8;A0A494C0U1;Q5VZU9;P29144 A0A494C1B8 TPP2 Tripeptidyl-peptidase 2 0 115681800.0 48213000.0 27172800.0 40296000.0 False True 62412678.920311935 25660609.793189086 32962541.471875753 1.0 0.4111441815524754 0.5281385455984366 25.895335801590285 -10.405596201026045 7.080990198809875 1.0000327794883672 0.46964136357595354 0.9647885427883311 0.04776274911567052 2.4718004207992803e-05 2.07491874508639e-06 0.04624892823370118 0.015415360991172916 3.9301017916795255e-11 10.405596201026045 -0.5303914159124137 ISMPDFDLHLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ISMPDFDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 323426400.0 71255100.0 153741000.0 98430300.0 False True 93416126.13536994 130803442.07772416 88245676.76610838 1.0 1.4002233606666157 0.9446514260100122 26.47716828360387 -6.674652827486521 1.9206173461478147 1.2544248480496059 0.9464385641941999 0.29996632467618023 0.1698247723765103 0.45050050586345564 3.207977320302059 0.07106941833340798 0.18875320302549894 2.1151792263041468e-07 6.674652827486521 -0.30798628385540594 ISMPDFDLHLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ISMPDFDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 278423400.0 106311100.0 56104900.0 116007400.0 False True 102936312.32225409 78507879.15318833 85621581.79259862 1.0 0.7626840070529269 0.8317918124417583 26.617176763351157 -9.983955230293637 6.449807459514775 1.000000056714437 0.797237909747339 0.9198575622586392 0.02821314340771296 2.3015414094086346e-08 3.5973738846593333e-09 0.02731726637465322 0.009105752880184205 1.0376353760459304e-10 9.983955230293637 -0.20276214696709793 ISMPDFDLHLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 ISMPDFDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 270564000.0 59511400.0 155815000.0 55237600.0 False True 90283144.66611525 128008595.86184853 44319864.148499906 1.0 1.4178570799150758 0.4908985427169539 26.427953334349592 -6.7841443247812965 1.5194933153404755 1.2353340298525504 0.48255089627431214 0.7818207590276438 0.17704823434416375 0.2442069788248154 1.113856445795114 0.09174373996106454 0.21576016382981275 1.6438253562453288e-07 6.7841443247812965 -0.7527831335782382 down ISMPDFDLHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ISMPDFDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 340608090.0 71255100.0 105788290.0 163564700.0 False True 97600036.0666735 101114213.5527063 124934086.58073723 1.0 1.0360059035596274 1.2800618894791291 26.54037834512676 -6.933311479249958 0.7190824935633447 0.996706007785962 1.334671420586888 0.9971501561624841 0.00664134374353761 0.09095415806789431 0.06951925602672662 0.006174542533611238 0.021694741848431398 1.1659730725023849e-07 6.933311479249958 0.33796541280092596 ISMPDFDLHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ISMPDFDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 235929000.0 106311100.0 57831100.0 71786800.0 False True 88402390.0302761 57519552.38572545 86797087.97533889 1.0 0.65065607803167 0.9818409654491532 26.397582038785433 -10.591337509175267 9.079152826018552 1.000035803182417 0.8162485221151775 0.2910060065245603 0.13520566411565446 9.80050360971587e-05 4.4112852279000245e-06 0.13093775623433795 0.04363744045273694 2.5624918383846937e-11 10.591337509175267 -0.18378728106723952 ISMPDFDLHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ISMPDFDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 200362900.0 59511400.0 104947000.0 35904500.0 False True 77038680.44507183 99106607.19417278 29370249.411280602 1.0 1.2864525537250766 0.38124029697291395 26.19907965644204 -6.821608877433145 1.3648406005553275 1.154152131648623 0.36077921361820725 0.8880524943478229 0.12639325786550915 0.19140146979414097 0.700131295646562 0.07276323185508764 0.1676446994500748 1.5079645171158557e-07 6.821608877433145 -0.7933729180304157 down ISMPDFDLNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISMPDFDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 18178300.0 2833400.0 6371700.0 8973200.0 False True 3714614.8386846334 5421067.196692066 8044739.341012308 1.0 1.4593887743720146 2.165699457513877 21.824781197550543 -6.964843926027091 0.36072675470259863 0.9396402668244711 2.7096795285360553 0.9999098847067438 0.00455127991456981 0.0780140352436113 0.015047344224669638 0.009462382875072473 0.06030167587149834 1.0843165187447787e-07 6.964843926027091 1.770039261711584 ISMPDFDLNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISMPDFDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 28075700.0 12225000.0 5839700.0 10011000.0 False True 11836924.06662668 8171522.663633195 7388818.776437578 1.0 0.6903417321626816 0.6242178064882412 23.49679089633095 -13.999999999999998 0.21699157722970158 2.844345845446837 0.5878120040992845 0.9994950622999186 0.0036807073210855692 12.919563749324256 0.14759407943020322 10.194377090032885 0.03733470168712819 1.0000000000000041e-14 13.999999999999998 -2.2565338413475526 ISMPDFDLNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISMPDFDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 24321400.0 2833400.0 10921000.0 10567000.0 False True 3880984.5497559183 10438474.109082455 8071292.234196328 1.0 2.6896458811563546 2.0797022329563113 21.887991259073434 -10.232452464154578 5.339342148919828 0.9998895602161778 2.3846740570564977 0.8729601435001657 0.24900845165763943 0.0003274056337539612 4.706535550169441e-05 0.24112017612104977 0.08036713219447944 5.855278219536768e-11 10.232452464154578 1.3847844968403198 ISMPDFDLNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISMPDFDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 20717100.0 12225000.0 3957000.0 4535100.0 False True 10165629.159326963 3935682.8555969936 5483368.442066773 1.0 0.38715585566939603 0.5394027616122297 23.277196171765226 -10.327536239833073 8.691385707044494 1.000000767549556 0.4632793086413739 0.943086774952542 0.06215453907957437 9.243771061045757e-07 7.160614416866605e-08 0.06018095976180747 0.02006029122886581 4.703961517404972e-11 10.327536239833073 -0.536721458908182 ISMPDIDFNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISMPDIDFNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 18295600.0 3054200.0 10202000.0 5039400.0 False True 4004085.7769148727 8679901.36708453 4517971.229338187 1.0 2.1677610947116994 1.1283402706770334 21.933041449742884 -6.61823255410808 2.1235453693335975 1.7758237794664435 1.1322960078746085 0.07672721014797101 0.502410083480388 0.59022221117358 5.0552044056849965 0.19458317777683903 0.5570846035972393 2.4086153285162323e-07 6.61823255410808 -0.643527771591835 ISMPDIDFNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISMPDIDFNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 28059700.0 7627300.0 7908400.0 12524000.0 False True 7385175.536472936 11066265.361761179 9243588.68805356 1.0 1.4984431049889821 1.2516410263239561 22.816200781795526 -10.145371567698001 4.53824083938651 0.9999517679209625 1.3750420656631208 0.7548382014867026 0.10075652672917423 5.058112508229805e-05 9.525471202476285e-06 0.09756996531214014 0.0325190291658892 7.155309641178274e-11 10.145371567698001 0.3750902977421583 ISMPDIDFNLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISMPDIDFNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 32060300.0 6006100.0 17732000.0 8322200.0 False True 9111692.804725727 14567586.05925166 6677313.522250162 1.0 1.598779323606725 0.7328290873444517 23.11928767758951 -6.720696567849189 1.7566188468878188 1.36403229568304 0.7341153227587813 0.5157522914921271 0.2519499614780487 0.3540357332921104 2.1353425126263543 0.11386226006698734 0.2856234561052312 1.9024069862689253e-07 6.720696567849189 -0.6299169729242586 ISMPDIDFNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISMPDIDFNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 21223800.0 3054200.0 6414600.0 11755000.0 False True 4183420.2766515557 6131181.761754438 8978711.10182433 1.0 1.4655906785110022 2.1462608363630546 21.996251511265775 -6.965680695146593 0.34617064781711804 0.9312545002527436 2.703430964862185 0.9999264975158576 0.004035449670406457 0.07773072774804002 0.01404968484414324 0.009438242426859552 0.058657155719818936 1.082229342660904e-07 6.965680695146593 1.7721764646094411 ISMPDIDFNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISMPDIDFNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 19038400.0 7627300.0 5804200.0 5606900.0 False True 6342437.896681761 5772931.622556509 6779276.866623494 1.0 0.9102070397215546 1.068875561268054 22.596606057229803 -6.753145094735392 1.6381660756037717 0.9474047368273103 1.0692702172368869 0.6625310280585057 0.03773865353937535 0.29452804160555596 1.5560021990959956 0.0181913378836613 0.04401948535654708 1.7654478984069997e-07 6.753145094735392 0.12186548040957657 ISMPDIDFNLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISMPDIDFNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 16205400.0 6006100.0 6099500.0 4099800.0 False True 7775014.847930745 5760057.463108584 3353678.4675004035 1.0 0.7408419888280439 0.43134045826201306 22.89041399968196 -6.968768065625213 0.2860833331728371 1.063378641438312 0.09929337315105116 0.9999711152779385 0.0012493172268461085 0.07670449163438728 0.010453974305886836 0.005523849966051592 0.028196672818215286 1.0745631281021932e-07 6.968768065625213 -0.9640852682872608 down ISMPDIDLNLTGPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISMPDIDLNLTGPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 12812100.0 2691000.0 4756400.0 5364700.0 False True 3527927.0596810686 4046763.6603019848 4809612.305836129 1.0 1.1470655690562435 1.3632969799185495 21.750389302633376 -6.965587388944532 0.34782400779301376 0.9785736734951492 1.539060993946853 0.9999247450973584 0.0012943659807792926 0.07776219268615851 0.014160289336194766 0.002984943843541387 0.0186128209981949 1.0824618797114919e-07 6.965587388944532 0.5604873204517037 ISMPDIDLNLTGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISMPDIDLNLTGPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 47161000.0 25260000.0 10174000.0 11727000.0 False True 24458135.12662494 14236531.256709082 8655346.897541054 1.0 0.5820775452831357 0.35388417198328864 24.543811070278906 -9.687601069825696 0.14947328653903366 1.6360009329054999 4.022344239543842e-06 0.999772050876814 0.004039304868248041 1.1582210057069815 0.06273289229212524 0.4942936831703205 0.19142782921607468 2.0530471818692845e-10 9.687601069825696 -1.6359969105612604 ISMPDIDLNLTGPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISMPDIDLNLTGPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 55547000.0 11735000.0 32455000.0 11357000.0 False True 17802852.943416968 26663151.67792759 9112283.972050073 1.0 1.497689823236277 0.511844028651574 24.085605118746418 -6.769457604256016 1.5764904283556151 1.2856632267869832 0.5064095376596552 0.7284748272949368 0.20972257503985606 0.26731912982335376 1.311077588059021 0.10486255999314681 0.24974483422940041 1.7003659349369703e-07 6.769457604256016 -0.779253689127328 ISMPDIDLNLTGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ISMPDIDLNLTGPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 37633360.0 3354510.0 6121450.0 28157400.0 False True 4594762.999224157 5850984.098071854 21507202.03985614 1.0 1.2734028064254488 4.680807702919108 22.13155901763673 -6.922854680872931 0.8032666297655383 0.9322671748411966 5.268064860005123 0.9949378398099532 0.1191339264404902 0.09652150611127172 0.09712213650911411 0.10422892441294576 0.32127190786458515 1.1943876912619078e-07 6.922854680872931 4.335797685163927 up ISMPDIDLNLTGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISMPDIDLNLTGPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 39839100.0 25260000.0 6883100.0 7696000.0 False True 21004809.20773817 6846019.374111618 9305198.017716458 1.0 0.3259262822339536 0.44300321539166493 24.324216345713182 -9.976419036663676 5.918682735839598 1.00000053827221 0.3844647488173746 0.9735837360285621 0.04779645781489156 3.39536056461708e-07 5.8722927910797596e-08 0.04627876196521871 0.01542624042699133 1.055798312040338e-10 9.976419036663676 -0.6155357894548353 ISMPDIDLNLTGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISMPDIDLNLTGPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 30238800.0 11735000.0 11604000.0 6899800.0 False True 15191188.83143263 10958227.199264202 5644107.197926552 1.0 0.7213541560743517 0.37153821603797915 23.856731440838868 -6.968046226970966 0.30122121978411387 1.0597959940689479 0.02211611625810725 0.9999628801272332 0.0015664979174626966 0.0769419185369106 0.011287292765545133 0.0057686884979741984 0.031333073243169814 1.0763506391187917e-07 6.968046226970966 -1.0376798778108407 down ISMPDLDLHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISMPDLDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 50499900.0 8288900.0 31887000.0 10324000.0 False True 10866828.169821784 27129583.894552477 9255771.514800873 1.0 2.4965503705942376 0.8517454560020588 23.373427569486875 -6.667254463122199 1.9473236295828336 1.9575105582166958 0.8585061385227221 0.2668163750476745 0.636111612807248 0.4674751138241629 3.414968429593702 0.26324096781038536 0.7057855235083537 2.151520739868487e-07 6.667254463122199 -1.0990044196939737 ISMPDLDLHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISMPDLDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 55061000.0 17311000.0 16179000.0 21571000.0 False True 16761471.780562334 22639359.072370406 15920907.983871248 1.0 1.3506784707667763 0.9498514326369683 23.998645498051534 -6.675575871740598 1.9177986812889616 1.222759297957096 0.9514335011950327 0.3038671345357393 0.14877283861521484 0.44845459508376256 3.185009540326686 0.06233851261322544 0.16533980587896144 2.1106884239255652e-07 6.675575871740598 -0.27132579676206336 ISMPDLDLHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ISMPDLDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 62221000.0 10568000.0 24686500.0 26966500.0 False True 14475275.189461615 23595768.802661296 20597568.09250073 1.0 1.6300739359925704 1.4229482909932039 23.78708743976268 -10.059202626531498 4.525179391048661 0.9999720928837978 1.5265111133985312 0.8960024461246874 0.08455869058839462 13112485.020863963 14574135.47762194 3058.8391481166623 0.028946690152033716 8.725641656498887e-11 10.059202626531498 0.5265390205147333 ISMPDLDLHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISMPDLDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 30307700.0 17311000.0 7263700.0 5733000.0 False True 14394863.507329991 7224569.00636844 6931743.793602968 1.0 0.501885203891626 0.4815428635411001 23.77905077348581 ISMPDLDLHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISMPDLDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 16638000.0 5126600.0 8700500.0 2810900.0 False True 6636484.7603939 8216309.526645825 2299345.0422695912 1.0 1.238051441883844 0.3464703265789036 22.661987840770653 -6.835654596226507 1.3023210390538476 1.126794281020313 0.31956156239655703 0.9167406927318295 0.10876199514146781 0.17393377116995967 0.5748876097223667 0.06552730675539396 0.15083991070145997 1.4599749482365338e-07 6.835654596226507 -0.807232718623756 down ISMPDLDLNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISMPDLDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 145698900.0 30285200.0 73159300.0 42254400.0 False True 39704190.48229399 62244217.6127178 37882320.02082538 1.0 1.5676989470538503 0.954113899834299 25.2427879453576 -6.663632512927586 1.960404547113734 1.3643283072002972 0.9566726555003219 0.25104061226697505 0.2415060019333664 0.4758570651279423 3.5194508078266025 0.09940799205393837 0.2677735339248602 2.1695391278158652e-07 6.663632512927586 -0.4076556516999753 ISMPDLDLNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISMPDLDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 168568600.0 56644300.0 35997400.0 75926900.0 False True 54846157.70202216 50371349.5439611 56039367.13182481 1.0 0.9184116381976549 1.0217555701218912 25.70888721905326 -6.696258390492393 1.8442842510171418 0.9491516372291483 1.0214266311503535 0.3997890524294565 0.034463696147676796 0.4033680194784849 2.664700234068284 0.014923204466783798 0.038555773262515844 2.012526508550183e-07 6.696258390492393 0.07227499392120518 ISMPDLDLNLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISMPDLDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 173619000.0 27333000.0 115920000.0 30366000.0 False True 41466159.309962995 95233170.31290622 24364146.790109403 1.0 2.2966479630059378 0.5875669991036637 25.305431091945657 -6.703837138718919 1.8168204449212175 1.8021423426459733 0.5922207537110723 0.43581118415065256 0.546962229559278 0.387679590684544 2.4903399265488364 0.2399153096106554 0.6141767521675179 1.977711146622401e-07 6.703837138718919 -1.2099215889349009 ISMPDLDLNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISMPDLDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 189515000.0 30285200.0 60859800.0 98370000.0 False True 41482456.8667565 58170812.79955465 75137031.99374405 1.0 1.4022991209609859 1.8112965737561675 25.30599800688049 -6.970919445253403 0.23519149892768804 0.8440980238748355 2.3812576221676665 0.9999886922561709 0.0011137586662566974 0.07600546443138816 0.00795473803551941 0.010118496010982645 0.040223168830380934 1.0692531903587354e-07 6.970919445253403 1.537159598292831 ISMPDLDLNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISMPDLDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 129891300.0 56644300.0 32720800.0 40526200.0 False True 47102245.217968404 32544526.555829756 49000041.04802249 1.0 0.6909336573071634 1.0402909844588497 25.489292494487536 -6.67322273481437 1.9258142827188809 0.8032689700550943 1.0389025514472705 0.29334971155608336 0.13118894461001984 0.4538270828298416 3.2478895665917227 0.054779894480623564 0.14575303961997235 2.122155801588548e-07 6.67322273481437 0.23563358139217616 ISMPDLDLNLKGPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISMPDLDLNLKGPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 23988500.0 14016000.0 4713700.0 5258800.0 False True 18375111.731137056 4010434.3338586874 4714669.821971601 1.0 0.21825360261961907 0.25657911042698495 24.13124968659413 -10.003401167487878 5.319726883752254 1.000003520919187 0.23741635652100107 0.9981092232397724 0.01564632305124176 86296215.82885134 60.01839216927214 4024.847886023545 0.005356152547038628 9.921991085670662e-11 10.003401167487878 -0.7625871643981861 ISMPDLDLNLKGPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISMPDLDLNLKGPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 94796500.0 10352000.0 61993500.0 22451000.0 False True 15704740.83257369 50930275.56757375 18013550.009377137 1.0 3.242987331693987 1.147013516581864 23.90469679932839 -6.630171131298408 2.079862248069337 2.4775458543383166 1.1554608629913732 0.11806989550232183 0.9620843819813469 0.5585829719840666 4.604982609312898 0.3783063496733883 1.0657444333361392 2.3433052671090807e-07 6.630171131298408 -1.3220849913469435 ISMPDLDLNLKGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISMPDLDLNLKGPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 36960500.0 14016000.0 17994200.0 4950300.0 False True 19198093.96815799 17199156.745137945 3781141.0946287583 1.0 0.8958783498853851 0.19695398412468282 24.194459748117023 -6.933509051328255 0.7174027956485651 1.0093698208498552 0.03974389172889822 0.9971840953943523 0.018920925025983925 0.09085628494840334 0.0690510407797485 0.017612915470109815 0.06206561298285234 1.1654427610629548e-07 6.933509051328255 -0.9696259291209569 down ISMPDLDLNLKGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISMPDLDLNLKGPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 55437800.0 10352000.0 24050800.0 21035000.0 False True 13400868.068426963 22712351.837647654 17206845.83732645 1.0 1.6948418357433843 1.2840097932063474 23.67582312142084 -10.220162924521004 4.494460240855279 0.9998713736368167 1.4894258144762929 0.6542512061736745 0.16772147964532594 0.00025722955039191714 4.463220632709882e-05 0.16244597831568616 0.05413187469703496 6.023335797033665e-11 10.220162924521004 0.4895544408394762 ISMPDVDFNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISMPDVDFNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 21738400.0 4046400.0 9255700.0 8436300.0 False True 5304869.585393344 7874785.638436015 7563392.602703855 1.0 1.4844447185127394 1.4257452480131134 22.338885853768836 -10.524726461238599 6.1195766999867605 0.9994381386428752 1.455094983262926 0.9876763259272165 0.023963958482606358 0.00018391594876210205 1.428370845131984e-05 0.02323018674664287 0.007734334342695025 2.9872635433224535e-11 10.524726461238599 0.45565684462005085 ISMPDVDFNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISMPDVDFNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 21806800.0 4046400.0 7613400.0 10147000.0 False True 5542463.429848362 7277014.813852975 7750487.584024812 1.0 1.3129567575788352 1.3983831706106287 22.402095915291728 -12.697668142948004 0.20067238081807093 1.860055115678488e-15 1.4568585998666719 0.9994336279824385 0.004075576154899865 7.242596487049392 0.1328152094813602 2.9462595322421814 0.05399884834727443 2.0060042881212341e-13 12.697668142948004 1.45685859986667 ISMPDVDLHLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ISMPDVDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 315706100.0 93928600.0 123569300.0 98208200.0 False True 123141304.20585632 105133242.10935888 88046557.54357485 1.0 0.8537609926041289 0.7150042636903269 26.87573951261964 -6.971762573744532 0.21191737330382523 1.0708935352241888 0.49398985778220567 0.9999930561693057 0.0003065739052614966 0.0757349569784371 0.0069461133826435395 0.004092564713950831 0.014315458103206665 1.0671793825153493e-07 6.971762573744532 -0.5769036774419831 ISMPDVDLHLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ISMPDVDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 389044500.0 169653600.0 70976300.0 148414600.0 False True 164268039.33168563 99317506.72651495 109540363.91743803 1.0 0.6046063928843498 0.6668391755517156 27.291476569983253 -10.56430878229596 6.363177140700981 1.0006152499848042 0.6357227842180495 0.9785793928902821 0.025406427134761198 0.00022211022618200455 1.5208024046193672e-05 0.024639207553145685 0.008199889098296864 2.7270381760046085e-11 10.56430878229596 -0.3648924657667547 ISMPDVDLHLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 ISMPDVDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 398114300.0 94865300.0 213632000.0 89617000.0 False True 143917595.6824141 175507700.48556554 71904160.66947353 1.0 1.2195013379243909 0.49962035794529186 27.10066774903584 -6.8248874202795875 1.3506276905708665 1.1177608022775207 0.482198572885035 0.8952528665299224 0.09750004683738836 0.18720447111249894 0.6696514789765539 0.05670778649911157 0.13056156924103235 1.4966235671395176e-07 6.8248874202795875 -0.6355622293924857 down ISMPDVDLHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ISMPDVDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 360727600.0 93928600.0 109969000.0 156830000.0 False True 128656541.74497198 105110205.96114723 119789984.01523717 1.0 0.8169829884709694 0.9310835064468743 26.93894957414253 -10.344448585871026 5.226283138649945 1.0000472233627962 0.874033247472806 0.6190595648445345 0.0465813414047332 2.5640597041150577e-05 3.2161963918226023e-06 0.04511908398838521 0.01503406329204034 4.5243002027426167e-11 10.344448585871026 -0.1260139758899902 ISMPDVDLHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 ISMPDVDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 293354400.0 169653600.0 74200200.0 49500600.0 False True 141074485.3288175 73800468.79501337 59850946.59508515 1.0 0.5231312283223907 0.4242506818691141 27.07188184541753 -13.999999999999995 0.22114916284196628 3.8922140234257836 0.37193815540528213 0.9994990697855286 0.005625960820500443 13.031104044427405 0.1489674473559454 16.469124379819736 0.054310985998484065 1.0000000000000123e-14 13.999999999999995 -3.5202758680205015 ISMPDVDLHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ISMPDVDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 270063500.0 94865300.0 108111000.0 67087200.0 False True 122805000.9246274 102094527.8127932 54878017.97280181 1.0 0.8313548067594949 0.4468711987265377 26.87179407112829 -6.957405617374074 0.47057647249786705 1.0100985922392722 0.2523502240200209 0.9996615369732278 0.004258500624407845 0.08064128065845233 0.024657059596419038 0.005321885117945285 0.03173224180982587 1.1030479266210421e-07 6.957405617374074 -0.7577483682192514 down ISMPDVDLHMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISMPDVDLHMK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 19397600.0 7071200.0 4697100.0 7629300.0 False True 9270411.677598204 3996310.9891524 6839893.221413228 1.0 0.43108236485434825 0.737819792614142 23.1442019763564 -10.098067167308532 5.350836398978061 1.0000062019338352 0.5844510787339723 0.709900030403706 0.1252250305052257 9.264927576253648e-06 1.5620459544178643e-06 0.12125042225941693 0.040416204806109024 7.978712801950515e-11 10.098067167308532 -0.4155551231998629 ISMPDVDLHMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISMPDVDLHMK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 15453700.0 5979800.0 2819600.0 6654300.0 False True 5789974.522177026 3945480.9840197572 4911339.20527905 1.0 0.681433220285788 0.848248845736266 22.465125569212308 -10.120499891780831 4.740561011612696 1.0000159234636983 0.764841033008549 0.7260010565507948 0.06810219392132824 1.1461995955299683e-05 2.1264668122222735e-06 0.06594412874048944 0.021979888573584162 7.577049216736645e-11 10.120499891780831 -0.23517489045514928 ISMPDVDLHMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISMPDVDLHMK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 21800000.0 7071200.0 5203700.0 9525100.0 False True 9685613.731994784 4973783.327665265 7275467.555592268 1.0 0.5135227839238741 0.7511622656971125 23.20741203787929 -10.141038489561474 5.079568937455542 1.000015932682894 0.632342524809919 0.7614192039222054 0.09701591218264202 1.750563878470153e-05 2.960222945566559e-06 0.09393932027170476 0.03131175101642108 7.227057506122233e-11 10.141038489561474 -0.36767340787297487 ISMPDVDLHMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISMPDVDLHMK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 11969000.0 5979800.0 3394000.0 2595200.0 False True 4972468.650056712 3375715.8483437495 3137844.3211509534 1.0 0.6788812732495053 0.6310435604486245 22.245530844646584 -13.999999999999998 0.2681057982161665 3.453496867538276 0.6148706990423508 0.9995792708977608 0.003360229974634529 14.7909134938646 0.16389468972113316 19.75712174431498 0.02005776494504952 1.0000000000000041e-14 13.999999999999998 -2.838626168495925 ISMPDVDLHVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISMPDVDLHVK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 47067000.0 20461000.0 14820000.0 11786000.0 False True 26824569.14460586 12608913.767907554 10566497.779295135 1.0 0.4700509335279696 0.3939111835248227 24.677051662856616 -13.999999999999998 0.27327938139929053 5.163324342421581 0.36943013072941067 0.9995904210496594 0.005455465960815427 15.04640906951421 0.16551622497176588 34.870870907317624 0.031112666707126337 1.0000000000000041e-14 13.999999999999998 -4.79389421169217 ISMPDVDLHVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISMPDVDLHVK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 41913000.0 10176000.0 10070000.0 21667000.0 False True 9852968.450060792 14091003.51435625 15991762.70393295 1.0 1.4301277412767224 1.6230400802546243 23.232127006888348 -11.352685224039167 0.14440050096022622 4.890473247378931e-19 1.8906761870148512 0.9996590553128211 0.0048087154226532335 3.9472573203949226 0.09006915006034516 1.457472106092198 0.19445193756745566 4.439302873315631e-12 11.352685224039167 1.8906761870148512 ISMPDVDLHVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISMPDVDLHVK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 57926000.0 10244000.0 34137000.0 13545000.0 False True 15540896.936716096 28044985.636401597 10867824.813015604 1.0 1.8045924730472929 0.6993048636298372 23.889566434933354 -6.711533724498058 1.7901131762446447 1.4938756781629299 0.7018238438057557 0.47224480345592157 0.3389704184494342 0.37198480606051443 2.324671814219639 0.15064802441943095 0.38195292613971393 1.9429708074350692e-07 6.711533724498058 -0.7920518343571742 ISMPDVDLHVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISMPDVDLHVK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 45993000.0 20461000.0 13070000.0 12462000.0 False True 28025984.6377341 12492524.183289777 9518732.262946393 1.0 0.4457479137582157 0.33963953045668915 24.740261724379508 -13.999999999999998 0.2324492770382415 4.538956138920637 0.2892364798221801 0.9995132348613085 0.006388172691362629 13.368823403556993 0.15263996626146453 21.866211280564425 0.054252817087117954 1.0000000000000041e-14 13.999999999999998 -4.249719659098457 ISMPDVDLHVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISMPDVDLHVK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 22188000.0 10176000.0 6994000.0 5018000.0 False True 8461794.873236096 6956321.933799692 6067240.599389447 1.0 0.8220858621616933 0.7170157975088227 23.012532282322624 -13.999999999940783 0.05613308103521544 2.183929166343936 0.19641230483292202 0.999963455950821 0.0007060319885481453 12.50367074288339 0.059077303695623286 2.1542277910909062 0.49182473872443977 1.0000000001363513e-14 13.999999999940783 -1.987516861511014 ISMPDVDLHVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISMPDVDLHVK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 35705000.0 10244000.0 14927000.0 10534000.0 False True 13261059.939428702 14096299.328112451 8616920.087967506 1.0 1.062984361167116 0.6497912027640477 23.660692757025803 -6.868027380981124 1.1444156817756799 1.0352333687791413 0.6264762123549776 0.9626778775677303 0.03511477598226321 0.13876371932519055 0.3408878576387616 0.02383940255110265 0.056258049792033235 1.3551039743646825e-07 6.868027380981124 -0.40875715642416366 ISMPDVDLNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISMPDVDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 23464900.0 5846300.0 9041800.0 8576800.0 False True 7664555.915649736 7692798.684660357 7689355.010475012 1.0 1.0036848539330183 1.0032355553404784 22.869770773882728 -10.53447714665204 5.956001335774463 0.9999941595688052 1.0034602046367418 0.9875004273674061 0.00018342538231225445 1.4249384455269468e-08 1.1136987950834748e-09 0.00017790066167407058 5.9200287580584863e-05 2.920941461297211e-11 10.53447714665204 0.003466045067936574 ISMPDVDLNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISMPDVDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 25701500.0 9763300.0 5981900.0 9956300.0 False True 9453369.385660224 8370503.865196404 7348446.347402405 1.0 0.8854518980178206 0.7773362118430739 23.17239719808622 -6.971825416205886 0.2100887390848658 1.0565408245685903 0.6032289094173782 0.9999933282695628 0.00023475903449473207 0.07571490995347446 0.0068699903590569485 0.0032352869356616037 0.011201097345443414 1.0670249727081e-07 6.971825416205886 -0.45331191515121216 ISMPDVDLNLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISMPDVDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 34941700.0 5019600.0 21168000.0 8754100.0 False True 7615100.181915279 17390405.013661105 7023848.297941662 1.0 2.283673832021371 0.9223579638022688 22.860431585813714 -6.659404787023091 1.974809287841583 1.8266764071102422 0.9280141338157811 0.2331737275559016 0.546634243717487 0.48584388436059045 3.641652755966339 0.22367330949468514 0.6060057111373542 2.1907620692954902e-07 6.659404787023091 -0.898662273294461 ISMPDVDLNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISMPDVDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 23606200.0 5846300.0 8861200.0 8898700.0 False True 8007835.100316939 8469682.88393016 6797010.334479314 1.0 1.0576744872774593 0.8487949925705012 22.93298083540562 -6.833087495196401 1.3142233430867385 1.0307566115691422 0.8428180641209659 0.9118787516191523 0.02614621357586674 0.17703378241088683 0.5969313118393258 0.01561605097727373 0.035934309906602305 1.4686303700216572e-07 6.833087495196401 -0.18793854744817629 ISMPDVDLNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISMPDVDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 19211000.0 9763300.0 5018400.0 4429300.0 False True 8118616.53752613 4991364.883125592 5355446.151230702 1.0 0.6148048574599312 0.6596500926576082 22.952802473520496 -10.580480109912 9.827928406058657 1.0000273289497703 0.6372274752358609 0.9886687982659547 0.018307990604901504 1.0963768701074662e-05 4.680297112648464e-07 0.01772796422105139 0.0059088785596087875 2.6273618532608964e-11 10.580480109912 -0.36279985371390944 ISMPDVGLNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISMPDVGLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 37957500.0 8946500.0 16971000.0 12040000.0 False True 11728948.138029244 14438992.952439861 10794216.295835186 1.0 1.2310560829938133 0.9203055695025764 23.48357030126995 -6.707594289632971 1.803688159044703 1.1423947029623545 0.921083091678861 0.4537169553700805 0.09740307058710833 0.37992884046175424 2.4078613026933984 0.04299820319043049 0.10955926749455021 1.960675447206056e-07 6.707594289632971 -0.22131161128349341 ISMPDVGLNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISMPDVGLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 37102200.0 13705000.0 7837200.0 15560000.0 False True 13269942.276737707 10966634.830458077 11484369.210005842 1.0 0.8264267169935364 0.8654422883314281 23.661658759317127 -10.618323516983374 6.50242088950908 1.0005080240285062 0.8459345026624824 0.9541093071734345 0.015928040300165175 0.00011768693341881361 6.9079432695165305e-06 0.01547222400897337 0.005140752901688359 2.408110897440465e-11 10.618323516983374 -0.15457352136602387 ISMPDVGLNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISMPDVGLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 50173500.0 8946500.0 23062000.0 18165000.0 False True 12254262.820071755 22043044.5841644 13874801.119918272 1.0 1.7988062527971247 1.1322428222440415 23.54678036279284 -10.171676866868747 4.3260697543154665 0.999888713191307 1.4655245375415291 0.3940645043589933 0.2721233811494014 190765660.4434713 53.36224433510958 230865.51494911968 0.09315507140355203 6.73477565191444e-11 10.171676866868747 0.4656358243502221 ISMPDVGLNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISMPDVGLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 25488500.0 13705000.0 6242700.0 5540800.0 False True 11396314.734443836 6209069.336021063 6699355.662235364 1.0 0.5448313319440873 0.587852811925899 23.442064034751404 -10.017392633863144 7.453808595239443 1.00000002055791 0.5663420725840291 0.9926727079147147 0.017563445655800126 5.995275716105967e-09 7.989233875929444e-10 0.01700573389194653 0.005668577710577714 9.607433036688577e-11 10.017392633863144 -0.4336579479738809 ISMPDVNLNLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ISMPDVNLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 49462300.0 15491400.0 17312900.0 16658000.0 False True 20309375.41893101 14729882.805155622 14934389.954819126 1.0 0.7252750269919888 0.7353446202436293 24.27564253684086 -10.073336109367524 5.011933570422964 1.0000061162763278 0.7303098236165203 0.9989555158070724 0.0041108942351194095 2.809563180745076e-07 5.194831902560615e-08 0.003980446479597363 0.0013267854085799136 8.446249196778185e-11 10.073336109367524 -0.26969629265980755 ISMPDVNLNLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ISMPDVNLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 49070900.0 16359100.0 8782800.0 23929000.0 False True 15839789.325018616 12289817.84169695 17661277.04538752 1.0 0.7758826578763544 1.1149944410871617 23.91704981138587 -6.728482374085858 1.728727738671987 0.8648994190036245 1.1147385156435319 0.5522199258256588 0.0942254705896399 0.33909647767438034 1.9846124803511258 0.04320569789547396 0.10739816829212116 1.868605513384037e-07 6.728482374085858 0.24983909663990733 ISMPDVNLNLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISMPDVNLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 50340900.0 9535900.0 30988000.0 9817000.0 False True 14466657.467671901 25457949.289650954 7876665.647056043 1.0 1.759767198922134 0.5444703218181348 23.786228288785825 -6.737680113574222 1.6951758170513846 1.4532784500036875 0.5441169801525582 0.594438498135665 0.319245367494868 0.3220562612909363 1.8162426079268563 0.14903883890632225 0.3666654071119047 1.8294472281068713e-07 6.737680113574222 -0.9091614698511293 ISMPDVNLNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ISMPDVNLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 71817700.0 15491400.0 20026500.0 36299800.0 False True 21218989.219343837 19141663.011220526 27726534.85784799 1.0 0.9021006049510802 1.306684996690214 24.33885259836375 -6.842779170506868 1.2693370838387033 0.9479208190450753 1.320747952248923 0.9291327891174147 0.04588006772279683 0.1655855375353662 0.5170306854482621 0.028327414257591665 0.0653210319504388 1.4362195347579003e-07 6.842779170506868 0.37282713320384764 ISMPDVNLNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISMPDVNLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 32633900.0 13630000.0 9482100.0 9521800.0 False True 11333948.911380492 9431018.04525052 11512764.35617106 1.0 0.8321034547615416 1.0157769764261968 23.43414726873084 -11.131292269321294 11.81199810096894 3.703828403440362 0.9239402155938667 0.1860931934057236 0.07498440122307279 0.037921121357034196 0.0004215002813594868 0.0005156605918366753 0.024201111430191335 7.391077066556305e-12 11.131292269321294 -2.7798881878464954 ISMPDVNLNLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISMPDVNLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 33014000.0 9535900.0 14444000.0 9034100.0 False True 12344410.530690951 13640178.702703545 7389986.4976938795 1.0 1.1049680070823167 0.598650415855883 23.557354610878274 -6.85262876272599 1.2223483111661269 1.0561657293871336 0.5773606278685374 0.9440452729326457 0.05161202440133475 0.15458622164164254 0.44315058709064253 0.03301654208303306 0.07654132067197113 1.4040133499688333e-07 6.85262876272599 -0.47880510151859623 ISMPEIDLNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISMPEIDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 17202300.0 5118600.0 6735100.0 5348600.0 False True 6710534.168592917 5730249.333214176 4795178.179394025 1.0 0.8539185092050147 0.7145747356204121 22.677996181011487 -6.97169938236795 0.2137471471065268 1.0695556822892964 0.49503115067954806 0.9999927731972261 0.0003132250265990187 0.07575509428754051 0.007022713709381701 0.004051198878250182 0.014316788656637857 1.0673346721711381e-07 6.97169938236795 -0.5745245316097484 ISMPEIDLNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISMPEIDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 24639700.0 11670000.0 5962700.0 7007000.0 False True 11299542.237835038 8343637.205069713 5171656.494505846 1.0 0.7384048866273658 0.45768725720491854 23.429760992198702 -6.970227198897485 0.2527069357236197 1.0861719383726691 0.10166997734579052 0.9999840984406378 0.0008830285315954574 0.07622909819755586 0.008766273000869941 0.006147945545291906 0.026786738116565827 1.0709588920922638e-07 6.970227198897485 -0.9845019610268786 down ISMPEIDLNLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISMPEIDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 30965200.0 6544600.0 19291000.0 5129600.0 False True 9928636.67434908 15848370.328729052 4115732.3116164557 1.0 1.5962282485040242 0.41453146555856646 23.243164200654164 -6.769534960223778 1.5763044924049714 1.3421809538022056 0.4080092013678454 0.7287715024329264 0.2512488530951116 0.26717193306469655 1.3100758905249188 0.12564360282839496 0.2992030846216021 1.70006309494167e-07 6.769534960223778 -0.9341717524343602 ISMPEIDLNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISMPEIDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 18534100.0 5118600.0 5132200.0 8283300.0 False True 7011084.744963877 4905442.434084144 6326955.139918467 1.0 0.6996695393830129 0.902421717903663 22.74120624253438 -10.06373003791207 4.9611535777498865 1.0000045058260207 0.8010456295217072 0.5621430778901181 0.08277323027356974 114820825.02509499 10.017021974698231 5910.121352554594 0.02833547836079091 8.635151512102423e-11 10.06373003791207 -0.19895887630431353 ISMPEIDLNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISMPEIDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 20666200.0 11670000.0 4826200.0 4170000.0 False True 9704122.068658132 4800200.302674307 5041927.720098446 1.0 0.49465580386480745 0.5195655706333911 23.210166267632978 -10.4541878088271 6.047648928514687 1.0002465294963103 0.5071106872491015 0.9980880752743511 0.010169369699128112 3.381919738093697e-05 3.0522296658308446e-06 0.00985125788558179 0.0032821499571790784 3.514084425581828e-11 10.4541878088271 -0.49313584224720886 ISMPEIDLNLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISMPEIDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 20292900.0 6544600.0 8156600.0 5591700.0 False True 8472113.713352688 7702678.039772346 4574067.975687099 1.0 0.9091801999343265 0.5398969053588155 23.014290522746613 -6.944498083526481 0.6162970135255451 1.004054038763193 0.4255829799607678 0.9986956858914044 0.007185974715386078 0.08577316793310145 0.04570576539159691 0.007261477697655281 0.03120951308104583 1.1363233120730241e-07 6.944498083526481 -0.5784710588024253 ISMPEVDLNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISMPEVDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 38674500.0 8121500.0 18961000.0 11592000.0 False True 10647365.148717886 16132092.709399134 10392571.03831572 1.0 1.515125337026851 0.9760697499481507 23.34399312215727 -8.775654445623102 18.631317665143843 1.0 1.2455975434875008 0.21677383368932857 0.2200685218898738 0.0 0.0 0.21308043007599073 0.07102681002533023 1.6762761054066584e-09 8.775654445623102 0.24559754348750085 ISMPEVDLNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISMPEVDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 47732000.0 18629000.0 12218000.0 16885000.0 False True 18037632.591999043 17096711.11602829 12462311.960857892 1.0 0.947835644662808 0.6909061872335621 24.10450666400723 -6.940141441375315 0.658248288497734 1.0028771103258456 0.6213317049299479 0.9981823371275743 0.005759941772794525 0.08770223943951846 0.05431668450046084 0.005612884605100792 0.022099672042679888 1.1477797507887939e-07 6.940141441375315 -0.38154540539589765 ISMPEVDLNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISMPEVDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 29689600.0 8121500.0 8371100.0 13197000.0 False True 11124238.025285063 8001237.1224741405 10080140.40074656 1.0 0.7192615893589804 0.9061420996058066 23.40720318368016 -10.105681299926243 4.774909941670589 1.0000100517629789 0.8127018449919874 0.5725216065053069 0.07629364883602717 8.164387588033608e-06 1.5290443706204801e-06 0.0738749720399631 0.024623669279319662 7.840047611001074e-11 10.105681299926243 -0.18730820677099147 ISMPEVDLNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISMPEVDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 32108400.0 18629000.0 6122800.0 7356600.0 False True 15490838.904630013 6089815.261119356 8894831.046924746 1.0 0.3931236583513362 0.5741994414689959 23.884911939441505 -10.380764453499713 5.075469182503532 1.0003715553626196 0.48366154991012394 0.9155508029618459 0.07392387890236385 0.0003110214881111851 3.7946130147430185e-05 0.07162662610195071 0.023858829322967446 4.161362473934211e-11 10.380764453499713 -0.5167100054524956 ISMPGFK(ub)GEGPEVDVNLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISMPGFKGEGPEVDVNLPK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 24754800.0 9989700.0 7341300.0 7423800.0 True False 9672582.441585312 10272719.37437375 5479284.070773871 1.0 1.062045160784391 0.5664758200681544 23.205469689457843 -6.875520533068721 1.1045426817235526 1.036580123215859 0.5342464193257208 0.9698859629373613 0.03825547322352081 0.131668768900959 0.2969317475332024 0.026779845121876006 0.06408136968606117 1.331924068602725e-07 6.875520533068721 -0.5023337038901381 ISMPGFK(ub)GEGPEVDVNLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISMPGFKGEGPEVDVNLPK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 34288900.0 9041000.0 15433000.0 9814900.0 True False 13715857.9856355 12678860.571420627 7874980.712976504 1.0 0.9243942730158834 0.5741515201764193 23.709341535971586 -6.9415224529209345 0.6452526995082474 1.003851395766 0.4753188325109588 0.9983564840577805 0.007520719922105906 0.08707913634586792 0.051499586773166066 0.007408183553610194 0.02994833685702749 1.1441357267442316e-07 6.9415224529209345 -0.5285325632550413 ISMPGFK(ub)GEGPEVDVNLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISMPGFKGEGPEVDVNLPK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 23151500.0 9989700.0 9417600.0 3744200.0 True False 8306878.168746707 9366865.519552754 4527094.908775207 1.0 1.1276035749259066 0.5449814980804308 22.98587496489212 -6.849307736671911 1.2383592595764603 1.0680593943461099 0.5219919521584747 0.9392953406136292 0.06161073375256809 0.15822619278681335 0.4672693110659499 0.038936490909268186 0.09006611792752969 1.414790918172724e-07 6.849307736671911 -0.5460674421876351 ISMPGFK(ub)GEGPEVDVNLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISMPGFKGEGPEVDVNLPK 19 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 27032300.0 9041000.0 12127000.0 5864300.0 True False 11703752.724753492 11452121.789510265 4797057.572799309 1.0 0.9784999784974074 0.4098734556014252 23.480467858064035 -6.914889930347453 0.8617676661652953 1.0150017584429198 0.3281497340638861 0.9926397654641872 0.02344361671192686 0.10127276592699212 0.12188345298639529 0.019670295043656257 0.05632765818309455 1.216494275656177e-07 6.914889930347453 -0.6868520243790337 down ISMQDVDLSLGSPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISMQDVDLSLGSPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 14498200.0 3211700.0 4883900.0 6402600.0 False True 4210569.802147038 4155241.1572930934 5740120.370075939 1.0 0.9868595825615498 1.3632645080836703 22.005584050859703 -6.898811969373908 0.9687673108474613 0.9838361813082563 1.4018323021565307 0.9859653117007429 0.020663709574861026 0.11228449059938181 0.18240155697802346 0.016032923790793248 0.041470898454917665 1.2623739693273855e-07 6.898811969373908 0.4179961208482743 ISMQDVDLSLGSPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISMQDVDLSLGSPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 20497700.0 5486100.0 2065600.0 12946000.0 False True 5311946.7584393155 2890404.851961696 9555054.22832492 1.0 0.5441328732012585 1.7987857677873746 22.340809255971266 -6.808416191229451 1.4213759521395917 0.7510889542874015 1.8199083854175893 0.8556003370141381 0.19704797624366702 0.20897112211925 0.8324171928386186 0.10902100993452038 0.2523510055355064 1.554475239526471e-07 6.808416191229451 1.0688194311301877 ISMQDVDLSLGSPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISMQDVDLSLGSPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 18637900.0 3211700.0 5796100.0 9630100.0 False True 4399152.282929012 5540009.136860432 7355668.718135143 1.0 1.259335612990379 1.6720650355021682 22.068794112382594 -6.964254967834636 0.3706220462511639 0.9684837827132176 1.9772972739750483 0.9998969462106174 0.0028093452424213933 0.07821476683768709 0.01575736302595361 0.0054349920844242875 0.0350411570934041 1.08578798647487e-07 6.964254967834636 1.0088134912618307 ISMSEVDLNVAAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISMSEVDLNVAAPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 18877300.0 3349800.0 6669300.0 8858200.0 False True 4391620.23950935 5674266.436727785 7941638.437854415 1.0 1.2920667378474733 1.8083618356631146 22.066321873607063 -6.962385291467267 0.40040053043136464 0.9717436806626155 2.1475490200431055 0.9998486924371512 0.004111110677000826 0.07885979568657504 0.018061858408971117 0.006642858164932652 0.04325062951651303 1.0904724766564949e-07 6.962385291467267 1.17580533938049 ISMSEVDLNVAAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISMSEVDLNVAAPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 14861300.0 3823800.0 2706700.0 8330800.0 False True 3702415.5620422964 3787499.4252540283 6148713.561357121 1.0 1.0229806356920126 1.660730260642438 21.82003540284993 -6.91453319135005 0.8642964528449683 0.9829707534719391 1.7516685514817436 0.9925226815050215 0.026477431567834265 0.10149617946331413 0.12307259795627322 0.022175522407049616 0.06331893105608309 1.217493941209775e-07 6.91453319135005 0.7686977980098045 ISMSEVDLNVAAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISMSEVDLNVAAPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 15623000.0 3349800.0 6866600.0 5406600.0 False True 4588311.584941195 6563210.907190316 4129672.4324222463 1.0 1.4304196185652966 0.9000418467603204 22.129531935129954 -6.6908835667445485 1.8637177739133004 1.2696282642102426 0.9018769172950625 0.3743962512552209 0.18200534382100328 0.4147543836678822 2.7939183275400654 0.07811248978317452 0.20315101444090317 2.0375882767640295e-07 6.6908835667445485 -0.3677513469151801 ISMSEVDLNVAAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISMSEVDLNVAAPK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9545800.0 3823800.0 2322000.0 3400000.0 False True 3179659.1230621208 2309490.925119089 4110924.280176191 1.0 0.7263328664284523 1.2928820735403959 21.600440678284205 -6.775324911230524 1.5537922287354553 0.8441054193078118 1.296753386844926 0.7506213229928018 0.11552471684666954 0.2578951803372881 1.2293827977969132 0.05857724535031633 0.13878439801494086 1.677548514511499e-07 6.775324911230524 0.4526479675371141 ISNEVLK(ub)SSPSYAMRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISNEVLKSSPSYAMRR 16 2 G3V5X4;A0A0A0MRE3;Q8WXH0;Q8WXH0-2;A0A0C4DGK3;Q8WXH0-7 G3V5X4 SYNE2 Nesprin-2 1 284487000.0 66781000.0 35026000.0 182680000.0 True False 87550537.70812388 29800257.330278676 163778025.99029648 1.0 0.34037777620083637 1.870668419379672 26.38361270348101 -6.789563103014565 1.4980140360432934 0.6311174993062769 1.8867626988613881 0.7999083993185326 0.28034000971868017 0.2360120075844558 1.0462854982396923 0.1473028461357646 0.34499162292531227 1.6234424470584282e-07 6.789563103014565 1.2556451995551112 ISNEVLK(ub)SSPSYAMRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISNEVLKSSPSYAMRR 16 2 G3V5X4;A0A0A0MRE3;Q8WXH0;Q8WXH0-2;A0A0C4DGK3;Q8WXH0-7 G3V5X4 SYNE2 Nesprin-2 1 102667000.0 25785000.0 18005000.0 58877000.0 True False 24966469.288995408 25194490.394834615 43455347.427860856 1.0 1.009133093798718 1.7405483700899143 24.57348847669057 -6.909624970785472 0.8982885732922293 0.9770842574113674 1.8343159738501955 0.9907791322824037 0.0333174534026702 0.10466661173572431 0.14011790975837732 0.0272269280750339 0.07496443797779452 1.2313316118558367e-07 6.909624970785472 0.8572317164388281 ISNEVLK(ub)SSPSYAMRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISNEVLKSSPSYAMRR 16 2 G3V5X4;A0A0A0MRE3;Q8WXH0;Q8WXH0-2;A0A0C4DGK3;Q8WXH0-7 G3V5X4 SYNE2 Nesprin-2 1 124720000.0 66781000.0 24575000.0 33364000.0 True False 91471740.3886672 23489195.24134245 25484110.35314909 1.0 0.25679182599495637 0.2786009126410633 26.4468227650039 -10.783005467140056 10.773328878853984 1.0033646330903352 0.2676963694000955 0.9993352394639563 0.008903522339851415 0.0007178386155530884 1.4458554611400706e-05 0.008600478829991839 0.0028735994787358514 1.6481416436728675e-11 10.783005467140056 -0.7356682636902396 ISNEVLK(ub)SSPSYAMRR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISNEVLKSSPSYAMRR 16 2 G3V5X4;A0A0A0MRE3;Q8WXH0;Q8WXH0-2;A0A0C4DGK3;Q8WXH0-7 G3V5X4 SYNE2 Nesprin-2 1 69070000.0 25785000.0 10568000.0 32717000.0 True False 21441369.969181653 10511068.086416245 39557973.43368364 1.0 0.49022371711901475 1.8449368436131435 24.353893752124847 -6.804773811669459 1.436379363840959 0.7204097059541593 1.8659074013871437 0.8457326099144384 0.21942929188637308 0.21402172043657786 0.8711996718627922 0.12015376816498341 0.27865666012116563 1.5675672746045123e-07 6.804773811669459 1.1454976954329843 ISNGGLEEGK(ub)PVDLVLSCVDNFEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISNGGLEEGKPVDLVLSCVDNFEAR 25 1 E7EQ61;Q9GZZ9;E7EWE1;Q9GZZ9-2;C9JRV9 E7EQ61 UBA5 Ubiquitin-like modifier-activating enzyme 5 1 44266900.0 6260900.0 13725000.0 24281000.0 True False 9498243.033100918 11275666.516085537 19481849.707259633 1.0 1.187131817620415 2.051100360284142 23.17922924046712 -6.9415988404295526 0.6445266529400497 0.9905064897003033 2.295461312166209 0.9983658063270633 0.01850685563505081 0.08704491518047094 0.05134623688391274 0.018241163047924065 0.0738520855285394 1.1439345038513667e-07 6.9415988404295526 1.3049548224659056 up ISNIVHISNLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISNIVHISNLVR 12 0 S4R3H4;E7EQT4;Q9UKV3-5;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2 S4R3H4 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 0 19112200.0 6219800.0 6200100.0 6692300.0 False True 8154218.032628882 5275069.24780051 5999844.993074573 1.0 0.6469129506584769 0.7357964882796064 22.95911510235704 -9.848364420043877 6.212735117995102 1.0000000216099034 0.691354719468927 0.9414430167554153 0.03628655228462059 1.0844700851071614e-08 2.022459925386935e-09 0.03513430578992885 0.011711434390740861 1.4178672783835273e-10 9.848364420043877 -0.3086453021409764 ISNIVHISNLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISNIVHISNLVR 12 0 S4R3H4;E7EQT4;Q9UKV3-5;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2 S4R3H4 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 0 19471500.0 6960300.0 3786600.0 8724600.0 False True 6739349.086375589 5298609.1268581385 6439365.527610359 1.0 0.7862197163179927 0.9554877548379734 22.684177826130995 -9.925619647145847 5.354558034928371 1.000000228165451 0.8708537356455125 0.43698836705107424 0.06910338735853075 1.8819266468916014e-07 3.770578764745252e-08 0.06690918524725444 0.022303022366803357 1.18680769317001e-10 9.925619647145847 -0.12914649251993848 ISNIVHISNLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISNIVHISNLVR 12 0 S4R3H4;E7EQT4;Q9UKV3-5;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2 S4R3H4 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 0 25011600.0 6219800.0 9008100.0 9783700.0 False True 8519428.143774917 8610092.356196832 7472991.561626432 1.0 1.0106420537730765 0.8771705606892044 23.02232516387993 -6.887607740761889 1.0364642040804521 1.0075882863936545 0.8662161300453689 0.9793211425330198 0.00870958246041355 0.12110419076028173 0.23337456144044944 0.006422176832664739 0.015878236516614186 1.2953653004850976e-07 6.887607740761889 -0.1413721563482856 ISNIVHISNLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISNIVHISNLVR 12 0 S4R3H4;E7EQT4;Q9UKV3-5;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2 S4R3H4 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 0 12825900.0 6960300.0 3106200.0 2759400.0 False True 5787797.843571646 3089466.2840675735 3336377.7819759357 1.0 0.5337895979727353 0.576450296321521 22.46458310156527 -9.951089733532525 7.174630429051529 1.0000000132647602 0.5551199478989363 0.9931506948457777 0.01741615717088814 3.686721444913202e-09 5.253513312568484e-10 0.01686312217200376 0.005621040556481463 1.1192066101190742e-10 9.951089733532525 -0.4448800653658239 ISNIVHISNLVRPFTLGQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISNIVHISNLVRPFTLGQLK 20 1 S4R3H4;E7EQT4;Q9UKV3-5;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2 S4R3H4 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 0 245552900.0 70722900.0 74974000.0 99856000.0 False True 68477840.25125824 104911509.18424504 73700717.9842124 1.0 1.5320504969097262 1.0762710639498914 26.029133864958556 -10.072160368515634 4.407049356248111 0.9999764898783144 1.3041607800316821 0.3725662934054075 0.1860711744274924 65092841.814771086 60378231.19327898 17747.39188834247 0.06809507632762901 8.469146228757016e-11 10.072160368515634 0.3041842901533677 ISNIVHISNLVRPFTLGQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISNIVHISNLVRPFTLGQLK 20 1 S4R3H4;E7EQT4;Q9UKV3-5;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2 S4R3H4 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 0 537453000.0 116573000.0 117783000.0 303097000.0 False True 176849763.62786034 96763703.40722072 243189745.0978654 1.0 0.54715200870066 1.3751205549225516 27.39794904987569 -6.758190735984362 1.6192108290069527 0.7363699161455827 1.3778848780468496 0.6835610733493431 0.19042331954503555 0.2859700184682732 1.4772890184535796 0.09280666132465477 0.2234355157958733 1.7450555809078573e-07 6.758190735984362 0.6415149619012669 ISNIVHISNLVRPFTLGQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISNIVHISNLVRPFTLGQLK 20 1 S4R3H4;E7EQT4;Q9UKV3-5;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2 S4R3H4 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 0 251875600.0 70722900.0 108703000.0 72449700.0 False True 58809224.90569857 108117395.36314398 87598597.30043568 1.0 1.8384427874455371 1.4895383749896598 25.809539140392832 -9.988404867717856 5.025197325048002 0.9999945210627444 1.6639905812255522 0.8284415143530981 0.14243962994801393 98054778.07738553 9.749863191098465 6216.331216059803 0.04876087399906696 1.027058384347772e-10 9.988404867717856 0.6639960601628078 ISNIVHISNLVRPFTLGQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISNIVHISNLVRPFTLGQLK 20 1 S4R3H4;E7EQT4;Q9UKV3-5;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2 S4R3H4 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 0 489990000.0 116573000.0 199423000.0 173994000.0 False True 150906046.49736613 188324934.74309418 142328877.3292025 1.0 1.2479614907039602 0.9431621902021445 27.16907537196814 -6.690359664362423 1.86516526830513 1.155403057262977 0.9442114915362918 0.3721201757486138 0.10486244646098067 0.41588312376797143 2.8053633706303307 0.04497214821159008 0.11705634790165441 2.0400477634313163e-07 6.690359664362423 -0.21119156572668518 ISNLIVLHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISNLIVLHLR 10 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 221714000.0 43280000.0 74864000.0 103570000.0 False True 56740499.1241162 63694583.017586455 92853569.91359213 1.0 1.1225594416830675 1.6364602241245871 25.757875505707137 -6.943793526660429 0.6232798251273198 0.994386092715806 1.7920123899347107 0.9986196821495876 0.010243742103492902 0.08607796882124336 0.047044439661897385 0.010285587851812104 0.04354589881676041 1.1381682679437382e-07 6.943793526660429 0.7976262972189047 ISNLIVLHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISNLIVLHLR 10 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 280741000.0 150050000.0 54063000.0 76628000.0 False True 145286744.8832175 75650637.83482055 56556828.00927569 1.0 0.5206988283454836 0.3892772740881245 27.114327844977005 -13.999999999999998 0.18156344380395228 3.4989351336410603 0.2865501834533298 0.9994963359022531 0.005890322791139448 12.225348868797422 0.13509040395078264 10.781479930884343 0.09683554639226251 1.0000000000000041e-14 13.999999999999998 -3.2123849501877304 ISNLIVLHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISNLIVLHLR 10 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 1420670000.0 314260000.0 528070000.0 578340000.0 False True 476755395.48344404 433831782.6702579 464030845.50457305 1.0 0.9099672217245485 0.9733101080776068 28.828674024838108 -10.084335803322555 4.906468070779159 1.0000018769299162 0.9416386649006686 0.5309264709989602 0.025859625068096435 5.309399144472297e-07 9.90903454998014e-08 0.025039279475393045 0.008346158102123816 8.235011247603322e-11 10.084335803322555 -0.058363212029247546 ISNLIVLHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISNLIVLHLR 10 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 459636000.0 43280000.0 91316000.0 325040000.0 False True 59281785.59802217 87281357.17836939 248272246.40893096 1.0 1.4723132290617336 4.1880021646516346 25.82108556723003 -6.936744448950612 0.6891966817406068 0.9671284812025718 4.855116895156214 0.9977054504707806 0.06729241400888138 0.08928406374109031 0.061614224154678814 0.06398799672654212 0.23728035179114068 1.1567927312388979e-07 6.936744448950612 3.887988413953642 up ISNLIVLHLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISNLIVLHLR 10 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 266169110.0 150050000.0 40881110.0 75238000.0 False True 124773223.34208684 40660875.34616503 90969917.93879294 1.0 0.3258782153498302 0.7290820538424624 26.89473312041128 -10.780527338649046 6.748103229188784 1.015609748173546 0.5274801345965945 0.6467896093840567 0.16460727777308462 0.03771525991064179 0.0012266347525320604 0.1554974573898035 0.05312677045664129 1.6575729900646897e-11 10.780527338649046 -0.4881296135769515 ISNLIVLHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISNLIVLHLR 10 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 1206400000.0 314260000.0 468700000.0 423440000.0 False True 406815764.99071306 442616432.9795876 346378264.8613028 1.0 1.088002164787522 0.8514376645880724 28.599800346930557 -6.80594439766985 1.4312787567146188 1.0481948788153934 0.8476627185050469 0.8490459709301088 0.03793052282489698 0.21237412223983096 0.8581520932823669 0.02084159529422817 0.04831065606345314 1.5633477838330728e-07 6.80594439766985 -0.20053216031034649 ISNLLSDYGYHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISNLLSDYGYHLR 13 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 10749000.0 2999500.0 2968700.0 4780800.0 False True 3932373.547199324 2525781.531901966 4286128.676671833 1.0 0.6423045780329931 1.089959696154618 21.906968943163065 -6.693932490337861 1.8528728983856464 0.77657550782258 1.0884722930956587 0.3887395657358924 0.1511616909463617 0.40824666205196547 2.720451081185899 0.06519830037950393 0.16891727909746654 2.0233336748610111e-07 6.693932490337861 0.31189678527307874 ISNTAISISDHTALAQFCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISNTAISISDHTALAQFCK 19 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 77210000.0 23859000.0 28783000.0 24568000.0 False True 31279380.05088463 24488688.59525526 22025939.032896902 1.0 0.7829019806472373 0.7041680173029508 24.89870858330253 -13.999999999999998 0.1411082250912974 2.0381004176449165 0.6080193781987765 0.9995985507947293 0.002506495476024934 11.935315305302352 0.11777266013535023 3.4095334758174562 0.08602143990972128 1.0000000000000041e-14 13.999999999999998 -1.43008103944614 ISNTAISISDHTALAQFCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISNTAISISDHTALAQFCK 19 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 38421900.0 22589000.0 7385700.0 8447200.0 False True 21871924.559593458 10334848.525916697 6234624.909431968 1.0 0.47251665018127675 0.2850515002666895 24.382576836148537 -13.999999999999998 0.14410359149194613 3.5303176904982965 0.06413542088268046 0.9995870927570285 0.0061504782144727555 11.94044638873534 0.11921807207629685 8.478271357263438 0.19809114831258162 1.0000000000000041e-14 13.999999999999998 -3.466182269615616 ISNTAISISDHTALAQFCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISNTAISISDHTALAQFCK 19 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 80007000.0 23859000.0 18265000.0 37883000.0 False True 32680317.065231275 17457991.905722067 28935815.62487551 1.0 0.5342050957117456 0.8854202842377085 24.96191864482542 -9.751688825027287 6.000632797040338 1.000000009376083 0.7098126899737016 0.47650159235033673 0.1433830003043183 1.781980271257337e-08 3.7922684460015236e-09 0.1388299972128195 0.046276664358455184 1.7713777079971058e-10 9.751688825027287 -0.2901873194023814 ISNTAISISDHTALAQFCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISNTAISISDHTALAQFCK 19 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 46989400.0 22589000.0 4020400.0 20380000.0 False True 18783754.362375192 3998741.3072130834 24641363.773526717 1.0 0.21288296418647615 1.311844442710804 24.162982111582814 -6.71446152879275 1.7794908713919413 0.5183160208063463 1.309596729108169 0.4861967350589852 0.3314652435448107 0.3661670966924559 2.2629227887038468 0.14808817225322765 0.37416562524676034 1.9299162868329344e-07 6.71446152879275 0.7912807083018226 ISNTAISISDHTALAQFCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISNTAISISDHTALAQFCK 19 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 83978000.0 24046000.0 34770000.0 25162000.0 False True 31128021.017522708 32835018.9347136 20582774.183922373 1.0 1.0548379839576048 0.6612297701911676 24.891710523737537 -6.871649444721859 1.1252831636342535 1.0313489943231091 0.6374387590216275 0.9663043590799074 0.031952738687861235 0.13528572302633962 0.3191585330039721 0.02201350056393024 0.0522743757999609 1.343849256221422e-07 6.871649444721859 -0.3939102353014816 ISNTAISISDHTALAQFCKEK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISNTAISISDHTALAQFCKEK 21 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 16088300.0 4044800.0 5499700.0 6543800.0 True False 5540271.866609983 5256705.068924155 4998289.213791412 1.0 0.9488171691727217 0.9021739968962565 22.40152534180559 -6.97223330735793 0.19769864798227305 1.0286010925478453 0.8211054538337524 0.999994942686481 8.965941373597216e-05 0.07558456577581234 0.006365446736767437 0.0015434268720341488 0.004980961574838785 1.066023288959956e-07 6.97223330735793 -0.20749563871409282 ISNTAISISDHTALAQFCKEK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISNTAISISDHTALAQFCKEK 21 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 13961700.0 5277300.0 1722100.0 6962300.0 True False 4388308.7740299525 1712822.7054899149 8418084.739961972 1.0 0.3903149923329037 1.9182981812447355 22.06523361081032 -6.79842506715664 1.4622991192421244 0.6629307165708023 1.9385865824647202 0.8275183954531952 0.2608237800716557 0.22301968410204584 0.9416428478211002 0.1403290001305771 0.32667672256255414 1.5906511098936355e-07 6.79842506715664 1.2756558658939179 ISNYGWDQSDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISNYGWDQSDK 11 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 16965300.0 4764800.0 1386500.0 10814000.0 False True 4613544.032119654 1940136.680501984 7981488.986953948 1.0 0.42053065213958835 1.7300125307977 22.137443995298728 -6.786420201100181 1.5106452624079019 0.6746174143781896 1.7425897649297226 0.789493334566945 0.24581668027535697 0.2407369653224221 1.085342105870418 0.12811065425918522 0.3007340629134118 1.6352335874905326e-07 6.786420201100181 1.067972350551533 ISNYGWDQSDK(ub)FVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISNYGWDQSDKFVK 14 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 10347200.0 3605400.0 4806400.0 1935400.0 True False 4726714.314743272 4089303.8552004574 1735143.373667724 1.0 0.8651472424397125 0.36709292293286544 22.17240623936062 -6.946709045514619 0.5938761497433312 1.0056941088153228 0.20131723648831423 0.9989170635249279 0.008957415946554536 0.08483476390412156 0.0416433843746146 0.00924978335954462 0.041773839134386724 1.1305530721765843e-07 6.946709045514619 -0.8043768723270086 down ISNYGWDQSDK(ub)FVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISNYGWDQSDKFVK 14 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 11116000.0 4107100.0 3763000.0 3245900.0 True False 3976722.358612873 5265585.523785758 2395701.4150872775 1.0 1.3241018730868743 0.6024311478267057 21.92314841086518 -6.784609243900887 1.5177977323837546 1.182415908679004 0.5958541203648994 0.783398558940595 0.1373545263838604 0.2434768520730943 1.1080828714119142 0.07125508292397228 0.1675043233489415 1.6420665567521012e-07 6.784609243900887 -0.5865617883141047 ISNYGWDQSDK(ub)FVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISNYGWDQSDKFVK 14 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 24927600.0 9901100.0 7398600.0 7627900.0 True False 15020692.567368178 6078262.024474357 6120242.221572664 1.0 0.40465923906059603 0.40745406339442913 23.84044799773434 -10.368848522611671 8.86653323815442 1.0000015052875535 0.40605665122752416 0.9999833932687975 0.0011409822564341684 3.3952015813724515e-08 2.415518063878531e-09 0.0011047541168796556 0.0003682504397906426 4.277120416399128e-11 10.368848522611671 -0.5939448540600294 ISNYGWDQSDK(ub)FVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISNYGWDQSDKFVK 14 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 9003400.0 3605400.0 2629700.0 2768300.0 True False 4938413.812271475 2513511.158744998 2114484.5549281407 1.0 0.5089713528054632 0.42817079234507516 22.23561630088351 -13.999999999999998 0.2539305334303961 4.483680138054688 0.396875606250118 0.9995502146409393 0.0053588793325829625 14.157265888479637 0.15945327380846092 25.21596741093503 0.036491501059605636 1.0000000000000041e-14 13.999999999999998 -4.08680453180457 ISNYGWDQSDKFVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISNYGWDQSDKFVK 14 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 61698600.0 2808000.0 57277000.0 1613600.0 False True 4259941.292297804 47055471.842756435 1294671.2527339954 1.0 11.046037636207613 0.30391762794356547 22.022402117640443 -6.661272936754097 1.9685345760206279 7.459829806168005 0.34878628679294577 0.2409375513918648 4.276098333825713 0.4814539075540336 3.58791009504806 1.7542327525446346 4.740474981138519 2.1813585841389736e-07 6.661272936754097 -7.11104351937506 ISNYGWDQSDKFVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISNYGWDQSDKFVK 14 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 11886700.0 1042400.0 4613600.0 6230700.0 False True 1427803.4498007917 4409755.896865006 4759136.985294509 1.0 3.088489453839223 3.3331877619139436 20.44536596219662 -10.218705481827804 0.46954121397323184 5.25388935941884e-24 3.333493206700279 0.9993213923859293 0.02727382957419296 1.550227885715201 0.21762935314889637 2.091403907032389 0.05266785697861053 6.043583379504682e-11 10.218705481827804 3.333493206700279 ISPIILNTVLTIMAALSPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISPIILNTVLTIMAALSPK 19 0 Q709C8-3;Q709C8;Q709C8-4;Q709C8-2 Q709C8-3 VPS13C Vacuolar protein sorting-associated protein 13C 0 9761500.0 3020700.0 4582800.0 2158000.0 False True 4582622.742750704 3764963.53442017 1731470.3541149986 1.0 0.8215739644674008 0.3778339285846797 22.12774209231219 -6.955573466482811 0.4938820132024724 1.0093778781412022 0.17108904689655996 0.9995691830215938 0.005429451046847955 0.08132191521732529 0.027275129892801907 0.006443075033474527 0.03659928340777847 1.1077111659706147e-07 6.955573466482811 -0.8382888312446422 down ISPIYGK(ub)EEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISPIYGKEEAR 11 1 Q9BX63;Q9BX63-2;J3QQP5 Q9BX63 BRIP1 Fanconi anemia group J protein 1 14063600.0 2859600.0 3549100.0 7654900.0 True False 3701808.5711431354 3351589.4650903665 6261786.745906828 1.0 0.9053924320174612 1.6915479624526235 21.819798861452398 -6.876838081658216 1.0973317964420701 0.9434973811638272 1.7439806819760078 0.9710419277557727 0.059633436783436855 0.13046536964378272 0.2895533403267105 0.04197604016576498 0.10073779075147339 1.3278894434815552e-07 6.876838081658216 0.8004833008121806 ISPK(ub)STGSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISPKSTGSVR 10 1 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 4686700.0 1236100.0 1922900.0 1527700.0 True False 1620539.0704094283 1636010.8154054936 1369628.2587331724 1.0 1.0095472829249075 0.845168304635282 20.628042373075537 -6.893120115459797 1.0037209826064797 1.0081830178761106 0.8301335435132033 0.9828220718497815 0.009874348183576432 0.11664893707453734 0.2073420165414421 0.007463317692363199 0.01882822079203025 1.2790275068362054e-07 6.893120115459797 -0.1780494743629073 ISPK(ub)STGSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISPKSTGSVR 10 1 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 6669000.0 1458900.0 2224500.0 2985600.0 True False 1412588.0180614868 3112754.450614255 2203581.793919889 1.0 2.2035826517103896 1.559960700320744 20.429909333676484 -10.143765246024534 5.7978360606157855 0.9999904270373218 1.8817716760156047 0.7144968103567066 0.2627575613599723 3.251400722532728e-05 4.802165667330184e-06 0.25441667427981135 0.08480463826975097 7.181823934016465e-11 10.143765246024534 0.8817812489782829 ISPK(ub)STGSVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISPKSTGSVR 10 1 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 9214830.0 1299700.0 658730.0 7256400.0 True False 1971739.9207975306 541174.4848190183 5822169.359406894 1.0 0.2744654500884294 2.952807973301032 20.911037837206013 -6.834548873509612 1.307384366911796 0.6133659505825879 3.031858078723112 0.9146883492673682 0.3303575984075312 0.17525850352408576 0.5842224555214116 0.19829510962949412 0.4564006509547587 1.463696810554447e-07 6.834548873509612 2.4184921281405245 up ISPK(ub)STGSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISPKSTGSVR 10 1 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 4967400.0 1236100.0 1571500.0 2159800.0 True False 1693119.5743464704 1502065.933744444 1649699.7224772614 1.0 0.8871588023097711 0.9743551178977016 20.69125243459843 -10.12310919639583 4.927959684000938 1.0000033043994074 0.9307569601561326 0.4567590768202704 0.03559774677449451 1.292414367221208e-06 2.2998869549826283e-07 0.03446901469150103 0.011489123368204748 7.53166168347209e-11 10.12310919639583 -0.0692463442432748 ISPK(ub)STGSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISPKSTGSVR 10 1 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 5913000.0 1458900.0 3401000.0 1053100.0 True False 1213139.9902283943 3382678.1379543548 1273298.341015749 1.0 2.7883658647816136 1.049588960278219 20.21031460911076 -6.639610764450256 2.045579267297194 2.1698261293119545 1.0567834521736374 0.15318393168421418 0.7652618422952614 0.534383897708521 4.27303903548493 0.3046806035831394 0.8475413236567493 2.2929217586180267e-07 6.639610764450256 -1.113042677138317 ISPK(ub)STGSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISPKSTGSVR 10 1 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 4794110.0 1299700.0 566110.0 2928300.0 True False 1682487.2709171688 534605.4808493161 2395379.446895319 1.0 0.31774711766935887 1.4237132656519498 20.682164159298463 -6.739857405438853 1.6876389478349787 0.5939880090175083 1.4242886177183685 0.6041416839555842 0.2866526891684198 0.31806466553490503 1.7787406276082354 0.13438675145616916 0.329771039516853 1.8202984302095894e-07 6.739857405438853 0.8303006087008602 ISPWDLFEGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISPWDLFEGLK 11 0 Q93074-3;Q93074;Q93074-2;Q7Z3Z5 Q93074-3 MED12;TNRC11 Mediator of RNA polymerase II transcription subunit 12 0 4018100.0 1072300.0 1115200.0 1830600.0 False True 1038260.4234473454 1560505.1756911727 1351110.9431771657 1.0 1.5029997681215792 1.3013218193283915 19.985736924862763 -10.104236707366535 4.468222632766789 0.999967212938776 1.4021607935756566 0.8413145708382298 0.08233467798905922 12582359.813201772 14226592.14126913 4003.169803617471 0.028185350535649138 7.866169360417318e-11 10.104236707366535 0.4021935806368806 ISQFLGICIQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISQFLGICIQR 11 0 S4R3W9;A0A0A0MRF4;P49406 S4R3W9 MRPL19 39S ribosomal protein L19, mitochondrial 0 40984000.0 10513000.0 14262000.0 16209000.0 False True 15948989.60325029 11716834.670485398 13005284.045342911 1.0 0.7346443230546461 0.8154299657134724 23.92696169380965 -10.24005551598712 7.633616303289538 1.0000003556200292 0.7750371443840592 0.9118112922026262 0.032980600509490345 1.9960761183592574e-07 1.985385276926491e-08 0.03193337980645316 0.010644443043431331 5.7536638338764376e-11 10.24005551598712 -0.22496321123596996 ISQFLGICIQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISQFLGICIQR 11 0 S4R3W9;A0A0A0MRF4;P49406 S4R3W9 MRPL19 39S ribosomal protein L19, mitochondrial 0 35406000.0 10513000.0 13696000.0 11197000.0 False True 13609285.742211407 12933805.560248418 9159260.890921991 1.0 0.9503662282681098 0.6730155472092895 23.698088015902098 -6.937359015016897 0.6836915591907256 1.003300950793636 0.603696897236026 0.9977971103146507 0.00675286525461569 0.08899244726430224 0.06025287185726939 0.006448628001532003 0.024161876335563128 1.1551569223279562e-07 6.937359015016897 -0.39960405355760986 ISQGNISK(ub)ACLILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISQGNISKACLILR 14 1 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 1 88604000.0 32442000.0 37914000.0 18248000.0 True False 42531776.16877488 32257378.98761452 16359872.007176116 1.0 0.7584300937635563 0.38465057142821313 25.342037768796114 -6.964736287929473 0.36255149119895974 1.0312841973959557 0.098936561927917 0.9999076031373445 0.0024332650660449234 0.07805058591564648 0.015176297413289413 0.004989765681680326 0.031877430802336196 1.0845852954317151e-07 6.964736287929473 -0.9323476354680387 down ISQGNISK(ub)ACLILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISQGNISKACLILR 14 1 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 1 94921000.0 40331000.0 37151000.0 17439000.0 True False 39050714.48107326 51985588.03990565 12871202.74121416 1.0 1.3312326990867618 0.32960223422934953 25.218845608708662 -6.817599741512995 1.382342105223983 1.1789792476857086 0.30886277078468816 0.8787358922649172 0.1450917254156011 0.19662861511909063 0.7389501358940549 0.08249605822420161 0.19026202559102412 1.521949556749988e-07 6.817599741512995 -0.8701164769010205 down ISQGNISK(ub)ACLILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISQGNISKACLILR 14 1 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 1 150007000.0 47880000.0 61123000.0 41004000.0 True False 72637460.49687281 50215123.09382121 32899541.427308336 1.0 0.691311655863617 0.4529280236707164 26.114210429166747 -7.462083793087092 0.16796890598935116 1.254369940333995 1.8898343760895826e-14 0.9999796663079676 0.0010098619010858048 0.1273034658073199 0.01414813275664087 0.03359109506320363 0.06307706392207196 3.450771534803885e-08 7.462083793087092 -1.254369940333976 down ISQGNISK(ub)ACLILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISQGNISKACLILR 14 1 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 1 95831000.0 32442000.0 42526000.0 20863000.0 True False 44436684.1120849 40647060.70532371 15935589.086972466 1.0 0.9147185825746487 0.35861337103320584 25.405247830319006 -6.934100175318112 0.7123352056261465 1.0073075645716996 0.23153661620263535 0.9972844522864134 0.014819860198019293 0.09056414761691442 0.06765623017062913 0.01384745929509293 0.04923295506838642 1.163857540512566e-07 6.934100175318112 -0.7757709483690642 down ISQGNISK(ub)ACLILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISQGNISKACLILR 14 1 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 1 86570000.0 40331000.0 25021000.0 21218000.0 True False 33537013.4662426 24886206.906720337 25654585.699052446 1.0 0.7420519698860508 0.764963335953442 24.99925088414294 -10.774444931660232 6.973765780930317 1.006589238329961 0.7535076529198328 0.9935619923720822 0.009353526029204213 0.0009730007217472172 3.147008542055111e-05 0.009195902654785456 0.003018837544952124 1.6809510560137536e-11 10.774444931660232 -0.25308158541012826 ISQGNISK(ub)ACLILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISQGNISKACLILR 14 1 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 1 118818000.0 47880000.0 60441000.0 10497000.0 True False 61981603.85590052 57077405.21809103 8586653.708315454 1.0 0.9208765450921351 0.13853551980162293 25.885336751259196 -6.9366507183307275 0.7844600131032117 1.012980147866102 3.735051337921941e-20 0.9957936901115614 0.025215577056604734 0.09198568915903234 0.08785260016813533 0.02252500829480709 0.07000357247286752 1.157042420345326e-07 6.9366507183307275 -1.012980147866102 down ISQILTTSPSLK(ub)SLSLAGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISQILTTSPSLKSLSLAGNK 20 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 119806000.0 26899000.0 55671000.0 37236000.0 True False 35264849.49028653 47365103.803858414 33383175.912933454 1.0 1.343125080312758 0.9466416671402108 25.071727546541503 -6.677817779820743 1.9092211181155898 1.217530674614023 0.9481650743564244 0.3141270629054347 0.14549627348132319 0.44352277748615243 3.123681522965727 0.06118551132600839 0.16185007231120324 2.09982073628626e-07 6.677817779820743 -0.2693656002575987 ISQILTTSPSLK(ub)SLSLAGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISQILTTSPSLKSLSLAGNK 20 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 242296000.0 38340000.0 59866000.0 144090000.0 True False 37122917.68625491 83770805.99706571 106348506.3926571 1.0 2.2565792566483154 2.864766915452704 25.145806768159503 -9.327927968570062 0.2216253441623384 1.5168424482691145e-22 3.363030164983669 0.9993425894473074 0.019908866481173185 0.7508791332474635 0.08381780319447972 0.8349573307090672 0.3044820697817447 4.699720509992501e-10 9.327927968570062 3.363030164983669 ISQILTTSPSLK(ub)SLSLAGNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISQILTTSPSLKSLSLAGNK 20 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 274348000.0 56114000.0 57704000.0 160530000.0 True False 85129040.48290572 47406270.356590174 128801175.1372015 1.0 0.5568754221552581 1.5130110054871972 26.343148033651232 -6.7806719952070225 1.5331104875274235 0.7493109181953598 1.520763991303167 0.7698025772806292 0.18744784215454574 0.2495344521364406 1.1584956561452848 0.09629242514986383 0.22709588177113132 1.6570209709059962e-07 6.7806719952070225 0.7714530731078072 ISQILTTSPSLK(ub)SLSLAGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISQILTTSPSLKSLSLAGNK 20 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 197314000.0 26899000.0 96098000.0 74317000.0 True False 36844287.21814228 91852072.60641024 56764855.206659175 1.0 2.492980039553646 1.5406691102632575 25.134937608064394 -10.014557124698948 5.295558435197026 0.9999938514175426 2.016824574910998 0.603190960215539 0.3887793088817657 2.8222291996265503e-05 5.251808756236054e-06 0.3764362223607885 0.12547798238613983 9.670365196381648e-11 10.014557124698948 1.0168307234934555 ISQILTTSPSLK(ub)SLSLAGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISQILTTSPSLKSLSLAGNK 20 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 173334000.0 38340000.0 52745000.0 82249000.0 True False 31881408.749987345 52460852.215937234 99446885.62359174 1.0 1.645499815498525 3.1192751362855384 24.92621204359378 -6.957375886069457 0.47096924972565435 0.9614378931793367 3.8638525175831453 0.9996601256110577 0.016351398337348885 0.08065229431050658 0.02469923362945436 0.020414623816107688 0.12163039610115152 1.1031234426081478e-07 6.957375886069457 2.9024146244038085 ISQILTTSPSLK(ub)SLSLAGNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISQILTTSPSLKSLSLAGNK 20 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 182375000.0 56114000.0 50383000.0 75878000.0 True False 72640679.17230588 47579141.75978352 62068982.57402683 1.0 0.6549930741551075 0.8544658899292135 26.11427435574368 -10.207586486555561 5.3680037222624275 1.0000136762382676 0.7547294820421202 0.6684204518953896 0.08143443603393316 1.3329446749184862e-05 1.9677088392413178e-06 0.07885294814484639 0.02628285121391426 6.200311567085855e-11 10.207586486555561 -0.24528419419614744 ISQLEK(ub)ELIEDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISQLEKELIEDLK 13 1 Q8IWI9-3;Q8IWI9;H3BP52;H3BTF4 Q8IWI9-3 MGA MAX gene-associated protein 1 16579900.0 4074300.0 5917100.0 6588500.0 True False 5341446.7555773305 5034291.744675153 5906785.221354655 1.0 0.9424959145045378 1.105839951542533 22.34879912479575 -6.811548262187659 1.4078463293780323 0.9687179580181197 1.1088048068203276 0.8638838863165352 0.0249591547736709 0.20468795396352085 0.799271504164896 0.013938466215858102 0.03222306499151655 1.5433049097248743e-07 6.811548262187659 0.1400868488022079 ISQLEK(ub)ELIEDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISQLEKELIEDLK 13 1 Q8IWI9-3;Q8IWI9;H3BP52;H3BTF4 Q8IWI9-3 MGA MAX gene-associated protein 1 21177500.0 6999700.0 9876900.0 4300900.0 True False 6777498.354942069 13820797.677353067 3174365.2657656916 1.0 2.0392181530040667 0.46836828273827363 22.692321427211255 -6.7283223315103875 1.729276803107777 1.626580402594824 0.46958677418035055 0.5514191983610461 0.4369265645951138 0.3394354399607496 1.9877768162514904 0.20028609745100243 0.49795648412799226 1.869294243176894e-07 6.7283223315103875 -1.1569936284144735 ISQLEK(ub)ELIEDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISQLEKELIEDLK 13 1 Q8IWI9-3;Q8IWI9;H3BP52;H3BTF4 Q8IWI9-3 MGA MAX gene-associated protein 1 13849100.0 4074300.0 7275700.0 2499100.0 True False 5580678.813817514 6954235.51647754 1908864.0505801106 1.0 1.246127173500679 0.34204872100036426 22.41200918631864 -6.8341664711990875 1.3091352295501402 1.131183508658379 0.3155730642602109 0.9139668899031859 0.11194012541790346 0.17572146362918736 0.5874867289386604 0.06710488168780789 0.15444374022495946 1.4649861834546475e-07 6.8341664711990875 -0.8156104443981681 down ISQLEK(ub)ELIEDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISQLEKELIEDLK 13 1 Q8IWI9-3;Q8IWI9;H3BP52;H3BTF4 Q8IWI9-3 MGA MAX gene-associated protein 1 18437700.0 6999700.0 9136600.0 2301400.0 True False 5820560.689287606 9087379.32232689 2782612.0995286736 1.0 1.5612549730907657 0.4780659884965902 22.47272670264553 -6.765874919148715 1.5901518084540827 1.3236151331847212 0.47288873295315603 0.7145582135247617 0.2363103521746243 0.27315795958188105 1.3624385878053895 0.11718045598211212 0.2800174233379391 1.7144510142515964e-07 6.765874919148715 -0.8507264002315652 down ISQLGYSCFYIHAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISQLGYSCFYIHAK 14 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 16528400.0 4052200.0 5742100.0 6734100.0 False True 5312473.441560625 4885401.062530497 6037319.9300484825 1.0 0.9196095032327035 1.1364423740582357 22.34095229307137 -6.806352629426982 1.430093214472018 0.955995308180873 1.1399172057452487 0.8500085918837167 0.03466302448738398 0.21182374067146845 0.8545267939632487 0.019063613172729164 0.04416963822666342 1.5618789455696343e-07 6.806352629426982 0.1839218975643757 ISQLGYSCFYIHAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISQLGYSCFYIHAK 14 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 17265200.0 4052200.0 4049600.0 9163400.0 False True 5550407.846587469 3870675.281763603 6999193.6461469345 1.0 0.6973677230121732 1.2610233048820396 22.404162354594263 -6.760859709150903 1.6091297457518816 0.8244012811109409 1.2631773626937401 0.6944912082809056 0.12730460794435286 0.2814841935396426 1.4366602844289966 0.06241424058922911 0.14987044105890138 1.7343641617349714e-07 6.760859709150903 0.43877608158279924 ISRPHPSTAESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISRPHPSTAESK 12 1 Q71RC2-5;Q71RC2-3;Q71RC2;Q71RC2-4;Q71RC2-6;Q71RC2-2;X6RLN4 Q71RC2-5 LARP4 La-related protein 4 0 7250000.0 2437200.0 2925500.0 1887300.0 False True 2359832.420055832 4093667.406280961 1392959.5122136294 1.0 1.734728013518904 0.5902789962435863 21.170252981733938 -6.733337249107227 1.7111859535329799 1.440503503452213 0.5905485360177807 0.5746366315070272 0.30878860570674577 0.3300052541492207 1.8945711849036844 0.14291929417148905 0.3532957303180205 1.847833136539693e-07 6.733337249107227 -0.8499549674344322 ISRPHPSTAESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISRPHPSTAESK 12 1 Q71RC2-5;Q71RC2-3;Q71RC2;Q71RC2-4;Q71RC2-6;Q71RC2-2;X6RLN4 Q71RC2-5 LARP4 La-related protein 4 0 3838070.0 407470.0 2245800.0 1184800.0 False True 618161.7800472183 1845019.443484513 950623.7606837113 1.0 2.9846870237489953 1.5378235784993013 19.23762493186668 -6.564776556114389 2.3271609332195538 2.363651319942822 1.5404437872434316 0.0 0.8655159365011894 0.7463134947806177 7.580383021201023 0.31536644544221154 0.9720151834042942 2.724102494403841e-07 6.564776556114389 -0.8232075326993904 ISSDLDGHPVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISSDLDGHPVPK 12 0 P29401;P29401-2;E9PFF2;F8W888 P29401 TKT Transketolase 0 19500600.0 3894300.0 1652300.0 13954000.0 False True 3770677.5781320473 2312072.006630672 10299028.788973127 1.0 0.6131714947041554 2.7313469729425006 21.846392363580833 -6.859598144182325 1.1877745019005255 0.7903446382936071 2.8331293352806317 0.9531483766485077 0.19934866545986354 0.14721739100612283 0.394890997822854 0.13092379823048492 0.3054762642914662 1.3816621352431112e-07 6.859598144182325 2.0427846969870247 up ISSDLDGHPVPK(ub)QAFTDVATGSLGQGLGAACGMAYTGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAYTGK 38 1 P29401;P29401-2;E9PFF2;F8W888 P29401 TKT Transketolase 1 98032000.0 23421000.0 32020000.0 42591000.0 True False 35531369.30445404 26305780.826598138 34172870.18170154 1.0 0.7403537027012513 0.961766204079779 25.082589952393175 -10.121373378397697 6.581480301001709 1.000000245667547 0.8510599535931147 0.3762994351148513 0.0903912751751123 3.258045895860553e-07 4.359460843109562e-08 0.0875211193059535 0.029173658616305043 7.561824985134518e-11 10.121373378397697 -0.14894029207443227 ISSDLDGHPVPK(ub)QAFTDVATGSLGQGLGAACGMAYTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISSDLDGHPVPKQAFTDVATGSLGQGLGAACGMAYTGK 38 1 P29401;P29401-2;E9PFF2;F8W888 P29401 TKT Transketolase 1 75572000.0 23421000.0 14042000.0 38109000.0 True False 30318946.196930815 13260550.356089966 31173553.031360738 1.0 0.4373684451286216 1.028187220917211 24.853716274485624 -9.123531179074277 14.76097102997288 0.9999995531476086 0.7327778330229112 0.214303762483256 0.24120075518978193 0.0 0.0 0.23354162698560704 0.07784720899520234 7.52434709086938e-10 9.123531179074277 -0.26722172012469736 ISSIGK(ub)FISGTPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISSIGKFISGTPR 13 1 Q9Y4B6;Q9Y4B6-2;Q9Y4B6-3 Q9Y4B6 VPRBP Protein VPRBP 1 7668600.0 1312300.0 1159600.0 5196700.0 True False 1270641.754816702 1622634.3272341127 3835528.3723417358 1.0 1.2770195226806376 3.018575737655524 20.277125903049154 -6.9348558361552275 0.7058044334338524 0.9776761349539551 3.4247347341769276 0.9974093669729164 0.04547546205161426 0.09019381329808651 0.06589718161420305 0.04270002852450086 0.15359203904631621 1.1618342201474944e-07 6.9348558361552275 2.4470585992229728 up ISSIGK(ub)FISGTPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISSIGKFISGTPR 13 1 Q9Y4B6;Q9Y4B6-2;Q9Y4B6-3 Q9Y4B6 VPRBP Protein VPRBP 1 7281700.0 1312300.0 2164800.0 3804600.0 True False 1091235.5947472202 2153137.792720846 4600124.269517155 1.0 1.9731190982819897 4.215518895883115 20.05753117848343 -6.957183348961641 0.4734621614933274 0.9427215398679419 5.338381909635073 0.999651051776492 0.025150762930787374 0.08072304288701419 0.024968506180033708 0.031210137798183445 0.18503583097417522 1.1036126021375853e-07 6.957183348961641 4.395660369767131 ISSILSSLTSVMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISSILSSLTSVMK 13 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 0 14135100.0 2769700.0 4053400.0 7312000.0 False True 3631103.5218129503 3448648.520029449 6555424.381656708 1.0 0.9497521894687253 1.805353205238195 21.7919766309074 -6.892957349555697 1.0046956626490042 0.957233648624797 1.8833604319110793 0.9827255818727311 0.05152506018013189 0.11677757269444348 0.20808058359000553 0.038915387570968074 0.09811149336826908 1.2795069536022843e-07 6.892957349555697 0.9261267832862823 ISSILSSLTSVMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISSILSSLTSVMK 13 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 0 20599400.0 7799900.0 4524600.0 8274900.0 False True 7552296.443949399 6331296.375477301 6107455.448321166 1.0 0.8383273117608732 0.8086885219149758 22.84848396403213 -13.99999999999999 0.23858997735951157 2.062854155479875 0.7954072421538319 0.9995226478102343 0.0018368820904759557 13.573986048065255 0.15460406423485656 6.86816530820933 0.014603547195408104 1.0000000000000246e-14 13.99999999999999 -1.267446913326043 ISSILSSLTSVMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISSILSSLTSVMK 13 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 0 20246500.0 2769700.0 6078800.0 11398000.0 False True 3793732.938328139 5810218.516096547 8706027.149178553 1.0 1.5315307140879173 2.2948444950411333 21.85518669243029 -6.965970961323309 0.3409771902806036 0.9181392750525632 2.9336405788501687 0.9999317840705205 0.004389262339210289 0.07763299936250216 0.013706648664359338 0.010743343690966535 0.06602103972909236 1.0815062627411758e-07 6.965970961323309 2.0155013037976053 ISSILSSLTSVMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISSILSSLTSVMK 13 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 0 14667500.0 7799900.0 3881700.0 2985900.0 False True 6485962.44415823 3860788.511642879 3610237.8847582587 1.0 0.5952529859497121 0.5566233100856025 22.628889239466407 -13.999999999999998 0.33225779759821195 5.466369116932579 0.5499615383756156 0.9997195086994175 0.0033583755934643994 19.015752951296818 0.1844469085511662 59.41946072257965 0.01227552062221147 1.0000000000000041e-14 13.999999999999998 -4.916407578556964 ISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMR ddPTM_RPMI8226_Bortezomib_8h_R1 4 ISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMR 34 0 P29401;P29401-2;E9PFF2;F8W888 P29401 TKT Transketolase 0 2252273000.0 495650000.0 671507000.0 1085116000.0 False True 751937286.8687357 551671329.3418626 870642346.9767625 1.0 0.7336666753675255 1.1578656387720123 29.48603710225672 -6.7369597951053946 1.6977989318478082 0.84098260947469 1.1579564168982943 0.5913013331305694 0.11191216504577758 0.32330863113438946 1.8286593543871685 0.052171838010338846 0.1284561520950438 1.8324840570806667e-07 6.7369597951053946 0.31697380742360437 ISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMR ddPTM_RPMI8226_Carfilzomib_8h_R1 4 ISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMR 34 0 P29401;P29401-2;E9PFF2;F8W888 P29401 TKT Transketolase 0 1167767500.0 495650000.0 409993500.0 262124000.0 False True 641628695.7221625 387177001.3117487 214420121.61936548 1.0 0.603428437495264 0.3341810038250121 29.25716342434917 -8.206983257024623 0.19972736090309656 1.2762650147002428 1.4391464904681773e-07 0.9997886898669059 0.003975311689615127 0.08661024804423166 0.041515328231497256 0.10492198849668466 0.11432709455844271 6.208929705123941e-09 8.206983257024623 -1.2762648707855937 down ISSIQSIVPALEIANAHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISSIQSIVPALEIANAHR 18 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 511830000.0 125000000.0 239400000.0 147430000.0 False True 163876210.5017221 203682453.1738913 132175357.8484204 1.0 1.2429043395029622 0.8065561038039223 27.288031196317135 -6.755632693356853 1.6290673806264688 1.141857249831096 0.8053055993789725 0.6728251094330695 0.10211172079653195 0.29031706836845084 1.5174591904520083 0.04948257575399062 0.11942541077512187 1.7553644821499703e-07 6.755632693356853 -0.33655165045212343 ISSIQSIVPALEIANAHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISSIQSIVPALEIANAHR 18 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 665850000.0 282200000.0 106370000.0 277280000.0 False True 273241715.46847004 148844095.71222207 204652049.77830508 1.0 0.5447341576560901 0.7489780593253534 28.02560251397598 -10.044919930537178 4.975538206798112 1.0000059003848374 0.6468561085331358 0.799440879206266 0.08338222370403617 5.781478454181844e-06 1.109736595201548e-06 0.08073591973737415 0.02691149697987364 9.0173737267148e-11 10.044919930537178 -0.3531497918517016 ISSIQSIVPALEIANAHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISSIQSIVPALEIANAHR 18 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 573342000.0 59214000.0 442330000.0 71798000.0 False True 89831967.12326299 363392755.55993605 57607093.82981864 1.0 4.045249894854317 0.6412761033137907 26.42072559028523 -6.670861007947935 1.9341425366520362 2.9423965448094256 0.6549763510829787 0.2827776771179913 1.293314908360359 0.45925058772152805 3.312938895550709 0.5381373686344064 1.4362491929070855 2.1337276842830527e-07 6.670861007947935 -2.287420193726447 ISSIQSIVPALEIANAHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISSIQSIVPALEIANAHR 18 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 919600000.0 125000000.0 354290000.0 440310000.0 False True 171215877.99798477 338636296.3196429 336317846.46910036 1.0 1.9778323148489108 1.9642912234638592 27.351241257840027 -10.19409977379242 5.3119561105955375 0.9999491442310774 1.9710617691566357 0.9998541817002086 0.0055281274098397245 3.3296311072406e-06 5.051619314970971e-07 0.005352864520589516 0.0017841954493751696 6.395878811878912e-11 10.19409977379242 0.9711126249255583 ISSIQSIVPALEIANAHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISSIQSIVPALEIANAHR 18 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 533850000.0 282200000.0 129910000.0 121740000.0 False True 234661803.5797192 129210149.04488395 147195271.13783804 1.0 0.5506228413564066 0.6272655749355175 27.806007789410256 -10.751098907810547 6.974379987743957 1.0075503995592996 0.5889442081462383 0.9745889169874317 0.03128926496014933 0.003686709339732126 0.00013157081006657777 0.030405145777818714 0.010098566842144132 1.773785466509336e-11 10.751098907810547 -0.4186061914130613 ISSIQSIVPALEIANAHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISSIQSIVPALEIANAHR 18 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 235043000.0 59214000.0 105440000.0 70389000.0 False True 76653690.28244148 99572171.31079093 57578924.25213081 1.0 1.2989873148168474 0.7511565854164755 26.19185191237768 -6.758483592670873 1.617978939822317 1.1739916423559043 0.7492891349235736 0.684846498277502 0.12572956454024672 0.285460883146183 1.47246331541602 0.06132001610231702 0.14759487180058906 1.7438792387085156e-07 6.758483592670873 -0.4247025074323306 ISSIQSIVPALEIANAHRK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISSIQSIVPALEIANAHRK 19 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 7514900.0 2331400.0 2284300.0 2899200.0 False True 3193381.583716012 2183372.072830057 2214468.6708982643 1.0 0.6837178757351488 0.6934557029421378 21.606653523122485 -10.069497548579436 5.369315980020831 1.0000031417768747 0.688586789338363 0.9992671858114819 0.0039754513110685785 1.4951658420348966e-07 2.591628727067437e-08 0.0038492530054439525 0.0012830713933101785 8.521233212647434e-11 10.069497548579436 -0.3114163524385116 ISSLLEEQFQQGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISSLLEEQFQQGK 13 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 62758200.0 8993200.0 26893000.0 26872000.0 False True 11790172.29027268 22880669.22809295 24091543.21442551 1.0 1.9406560535990076 2.0433580291529676 23.49108146484523 -10.948225766974561 0.40626497041553156 2.455626973767776e-13 2.0505094590120003 0.9995226798978386 0.01025774523345105 2.7039414171768223 0.19843902842999317 2.5775058849333847 0.02576773868315858 1.1266116374855915e-11 10.948225766974561 2.0505094590117547 ISSLLEEQFQQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISSLLEEQFQQGK 13 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 62569100.0 16535000.0 7535100.0 38499000.0 False True 16010105.47580142 10543904.725027394 28414956.954756808 1.0 0.6585780925031411 1.7748138510208307 23.93247947668247 -6.824618420046814 1.3517661546985107 0.8167792986103876 1.8016816412707881 0.8946660717151825 0.1515690788725525 0.18755798027857337 0.6721244679249194 0.08808109702464578 0.20280739551364046 1.4975508568298347e-07 6.824618420046814 0.9849023426604006 ISSLLEEQFQQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISSLLEEQFQQGK 13 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 60610200.0 8993200.0 34157000.0 17460000.0 False True 12318229.072091794 32647830.797905825 13336307.599987494 1.0 2.6503672408457497 1.0826481243316266 23.55429152636812 -6.634225612289099 2.066669387346134 2.0839946520169157 1.0892300938272415 0.13247568886530203 0.7071825328095218 0.547981929913007 4.466268364066013 0.2794494406796499 0.7825373226687619 2.3215304677152142e-07 6.634225612289099 -0.9947645581896742 ISSLLEEQFQQGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISSLLEEQFQQGK 13 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 27875000.0 16535000.0 6594500.0 4745500.0 False True 13749585.124701148 6558974.11959423 5737762.109287096 1.0 0.47703069293421985 0.4173043809866815 23.712884752116747 -13.999999999999998 0.30625192149404407 5.945907508516857 0.4035392249285925 0.999663728117842 0.004799819155291554 17.007339142460626 0.1759495100371808 53.490585783013955 0.021020655323750744 1.0000000000000041e-14 13.999999999999998 -5.542368283588265 ISSLLEEQFQQGK(ub)LLACIASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISSLLEEQFQQGKLLACIASR 21 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 38580900.0 11326000.0 8362300.0 18892600.0 True False 9418070.826874215 8317250.630113401 22842955.31048728 1.0 0.8831161692244177 2.4254388961808946 23.16700014152585 -6.888626719989579 1.0305023544082637 0.9143799753618213 2.5545634292226644 0.9800035547330691 0.09914647857519591 0.12026321746010432 0.2284278274648174 0.07343885905289037 0.18219703032607099 1.2923295652685227e-07 6.888626719989579 1.640183453860843 up ISSLLEEQFQQGK(ub)LLACIASRPGQCGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISSLLEEQFQQGKLLACIASRPGQCGR 27 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 45524400.0 6710800.0 4539600.0 34274000.0 True False 8687262.889644489 4286967.2693708865 28036483.680937774 1.0 0.4934773269588856 3.227309226978524 23.050470265633024 -6.858851005425069 1.191548078621496 0.7259836430083046 3.3568068895310965 0.9522279954632973 0.2595485922061993 0.14798823505124564 0.39991058276011016 0.16997225182435766 0.39626163327865527 1.3840411242387083e-07 6.858851005425069 2.630823246522792 up ISSLVK(ub)DASVPLIDVTNLPTPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISSLVKDASVPLIDVTNLPTPR 22 1 Q96A65;Q96A65-2 Q96A65 EXOC4 Exocyst complex component 4 1 14047300.0 5029200.0 6711100.0 2307000.0 True False 4182002.6313363705 6674945.972250946 2789383.0336371944 1.0 1.5961123319805155 0.6669969580449162 21.99576253900268 -6.73343416279924 1.7107510047708392 1.357357077400163 0.6671971058643673 0.5751098479656322 0.2505305241595168 0.3298293478057583 1.892625316599539 0.11598062666935224 0.2866812602316963 1.8474208348426553e-07 6.73343416279924 -0.6901599715357958 ISSPLFNTK(ub)QYTMELER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISSPLFNTKQYTMELER 17 1 O15294;O15294-3;O15294-2;O15294-4 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 27301300.0 12079000.0 6274600.0 8947700.0 True False 11695558.756710326 8780080.501606729 6604028.944753812 1.0 0.7507191989924515 0.5646612600671815 23.479457452475508 -7.126065610600043 0.12134214770920264 1.3387693405183219 1.269959796548481e-12 0.999999164560901 0.00016291377382463842 0.08007249191979363 0.004373936542031939 0.01627966815986226 0.030875701097322288 7.480564800972512e-08 7.126065610600043 -1.338769340517052 ISSPLFNTK(ub)QYTMELER ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISSPLFNTKQYTMELER 17 1 O15294;O15294-3;O15294-2;O15294-4 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 41097400.0 20010000.0 16878000.0 4209400.0 True False 30356632.92695125 13865989.031584103 3377410.2449544347 1.0 0.45676966430863913 0.11125773576673255 24.855508444128986 -8.35541810566344 0.3623894805449564 1.10866225114291 1.1474063759470694e-20 0.9978079311535121 0.01712696703059116 0.12954581264419318 0.09787890097393666 0.08582099506301025 0.08618357665952436 4.411455415105888e-09 8.35541810566344 -1.10866225114291 ISSPLFNTK(ub)QYTMELER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISSPLFNTKQYTMELER 17 1 O15294;O15294-3;O15294-2;O15294-4 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 18067100.0 4493200.0 6719000.0 6854900.0 True False 6154457.464164355 6422132.363238261 5235913.801097034 1.0 1.0434928506099035 0.8507514807900228 22.553200253286874 -6.847420434319497 1.2474380717229892 1.0231679573722126 0.8434197781432229 0.9364753400407096 0.02080351670110562 0.16031407972462455 0.4813498511939763 0.013057885649586778 0.030171784180430292 1.4209525171070417e-07 6.847420434319497 -0.17974817922898967 ISSPLFNTK(ub)QYTMELER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISSPLFNTKQYTMELER 17 1 O15294;O15294-3;O15294-2;O15294-4 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 26022800.0 12079000.0 10656000.0 3287800.0 True False 10044223.690430304 10598594.012949614 3975263.7789303726 1.0 1.055192948664364 0.39577610987674733 23.259862727909784 -6.886578343527501 1.042447814756127 1.0383920025013837 0.3427284640487921 0.9786149408237708 0.04367991937738371 0.12196173737449685 0.23843508373665018 0.03206217456043214 0.07900508388622085 1.298439313807487e-07 6.886578343527501 -0.6956635384525917 down ISSPLFNTK(ub)QYTMELER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISSPLFNTKQYTMELER 17 1 O15294;O15294-3;O15294-2;O15294-4 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 51117000.0 20010000.0 15029000.0 16078000.0 True False 25903339.456068713 14192622.938447226 13151968.974211283 1.0 0.547907074395465 0.5077325646184203 24.626634766221436 -13.999999999999998 0.34265758412633057 6.314513962898273 0.501630402185719 0.9997404735906711 0.0035955678890042223 19.950387322046634 0.18794063919264117 76.90066501855966 0.012295999030030695 1.0000000000000041e-14 13.999999999999998 -5.812883560712554 ISSPTETER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISSPTETER 9 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 70792000.0 24525000.0 7623000.0 38644000.0 False True 23746467.299306266 10666903.65341985 28521977.10485005 1.0 0.44919960173324286 1.2011040103503436 24.501209567597954 -6.710358044237375 1.794001725998843 0.6615036600893233 1.1993509072493869 0.46677849994931453 0.2320911055703111 0.37435171834053865 2.3488479886392994 0.10294521529358887 0.2614085871277376 1.9482377570467374e-07 6.710358044237375 0.5378472471600636 ISSPTETER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISSPTETER 9 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 5632900.0 1354600.0 1940600.0 2337700.0 False True 1753556.4031579564 1832603.9040755008 1912262.586827572 1.0 1.0450783908491275 1.0905053201504118 20.74185240496057 -6.971029503707444 0.23228265983807936 0.9820446198887108 1.154840654033817 0.9999893127109791 0.00012065259729128514 0.07597004772314116 0.007824485112302909 0.00114784274460149 0.004492042643385516 1.0689822556633715e-07 6.971029503707444 0.17279603414510614 ISSQQNPNSNTLGHILCVIGHIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISSQQNPNSNTLGHILCVIGHIAK 24 0 G3V1A9;P42695;E9PKK4 G3V1A9 NCAPD3 Condensin-2 complex subunit D3 0 4122300.0 1319600.0 1293200.0 1509500.0 False True 1807491.7808491227 1236062.1479594733 1152987.1891283588 1.0 0.6838549204239239 0.6378934617266746 20.78555765619342 -13.999999999991589 0.27159099645412044 3.4611018330949896 0.6228708804564163 0.9995867579360824 0.003272104772796334 14.961620624686828 0.16498736409113385 20.350157196093477 0.018938164456710708 1.0000000000193672e-14 13.999999999991589 -2.8382309526385736 ISTINILLSTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISTINILLSTLK 12 0 O60287 O60287 URB1 Nucleolar pre-ribosomal-associated protein 1 0 7406500.0 0.0 3279100.0 4127400.0 False True 0.0 2693918.9852747656 3311617.5808963114 0.0 ISTINILLSTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISTINILLSTLK 12 0 O60287 O60287 URB1 Nucleolar pre-ribosomal-associated protein 1 0 4508900.0 0.0 2125900.0 2383000.0 False True 0.0 2007591.796183709 1949318.4516448264 0.0 ISTISSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISTISSVR 8 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 2286450.0 580980.0 336670.0 1368800.0 False True 562537.1079123741 471104.08671085635 1010270.2168802071 1.0 0.8374631292487816 1.7959174651240537 19.101588741673833 -6.863246658763104 1.169124112099452 0.9109227975220091 1.8453146263932005 0.9574716047051325 0.08636657599073728 0.14350022359292652 0.37086873752288885 0.0575334905291745 0.1348391857457275 1.3701033911007264e-07 6.863246658763104 0.9343918288711914 ISTLTIEEGNLDIQRPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISTLTIEEGNLDIQRPK 17 1 Q12972;A0A0A0MT09;Q12972-2 Q12972 PPP1R8 Nuclear inhibitor of protein phosphatase 1;Activator of RNA decay 0 4801400.0 1070300.0 1943200.0 1787900.0 False True 1403173.6647999443 1653282.1345342759 1602905.2587478189 1.0 1.1782448431071364 1.1423427469873098 20.420262145524006 -10.104445706551324 4.516118133811164 0.9999858619724095 1.1602937950511683 0.9637400317570068 0.014656969386755701 2.135696172868997e-06 4.2352160808030733e-07 0.014192830452748658 0.004730516525326391 7.862384768320997e-11 10.104445706551324 0.1603079330787588 ISTLYYQLGDHELSLSEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISTLYYQLGDHELSLSEVR 19 0 Q13217;X6R9L0 Q13217 DNAJC3 DnaJ homolog subfamily C member 3 0 83260000.0 3832000.0 33262000.0 46166000.0 False True 3710355.2575307544 46543690.05903857 34073739.649687 1.0 12.544267820330889 9.18341702739352 21.823125897340173 -9.781802772061557 7.5392146833688125 0.9999999935476546 10.863842423862247 0.9199041432662336 1.3720615907209477 1.4571117327013047e-07 2.100598930759192e-08 1.3284927742375532 0.4428309742360683 1.6527121808058945e-10 9.781802772061557 9.863842430314593 ISTQLDFASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISTQLDFASK 10 0 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 0 31885000.0 7845200.0 7442800.0 16597000.0 False True 10285133.173024876 6332363.251807169 14879701.649665823 1.0 0.6156812114416997 1.4467193957868487 23.29405713836789 -6.780961715827372 1.5320842025614123 0.7826555925122667 1.4535044925909248 0.7707595428440711 0.16259182494028884 0.2491011165988298 1.1549690520974318 0.08357950998530495 0.19705785299857975 1.6559159302727533e-07 6.780961715827372 0.6708489000786582 ISTTQIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISTTQIER 8 0 G3V0H7 G3V0H7 SLCO1B7 Putative solute carrier organic anion transporter family member 1B7 0 7799890.0 180990.0 4881800.0 2737100.0 False True 237279.64270965307 4153454.4691073573 2453891.1481171497 1.0 17.504470344258426 10.34176855668925 17.856228804965898 -10.671275914633247 10.917820287406958 0.9966704506771235 13.92311945047367 0.81274459002613 2.9241607598775756 0.2354142934102658 0.007088084787666433 2.8123120246844255 0.9437688270532553 2.1316901840057748e-11 10.671275914633247 12.926448999796547 ISTTQIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISTTQIER 8 0 G3V0H7 G3V0H7 SLCO1B7 Putative solute carrier organic anion transporter family member 1B7 0 7643390.0 180990.0 3728000.0 3734400.0 False True 247906.8940708417 3563284.6331525864 2852411.632382207 1.0 14.373479392365526 11.505979464883715 17.91943886648879 -9.099675829742258 11.08276006823817 1.0000000000003721 12.939729428650857 0.9585345030664191 1.170651943302866 0.0 0.0 1.1334788701529088 0.3778262900509695 7.949213661711286e-10 9.099675829742258 11.939729428650484 ISTVVSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISTVVSSK 8 0 P37108;H0YLA2 P37108 SRP14 Signal recognition particle 14 kDa protein 0 10686800.0 2698400.0 4865900.0 3122500.0 False True 3537628.5313427714 4139926.687129649 2799413.653134994 1.0 1.170254776738321 0.7913249309057403 21.754351135123724 -6.784552963049882 1.5179136868595302 1.095835449439023 0.7878727152078325 0.7832032800754962 0.07215266519039881 0.24358417126229157 1.1087225174565263 0.03742659499367491 0.08798916413599858 1.6422793683247786e-07 6.784552963049882 -0.30796273423119047 ISTVVSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISTVVSSK 8 0 P37108;H0YLA2 P37108 SRP14 Signal recognition particle 14 kDa protein 0 5402200.0 1841500.0 1121000.0 2439700.0 False True 1783042.5904861374 1568621.1459377718 1800669.3805688496 1.0 0.879744070224422 1.0098857930689733 20.76590973350373 -13.60080668854884 11.602049117374523 8.81484998740141 0.9503334384820289 0.0 0.0605422970076172 0.0 0.0 0.0 0.017615885996088647 2.5072250108255927e-14 13.60080668854884 -7.86451654891938 ISTVVSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISTVVSSK 8 0 P37108;H0YLA2 P37108 SRP14 Signal recognition particle 14 kDa protein 0 8499500.0 2698400.0 2487100.0 3314000.0 False True 3696071.4015180925 2377211.698260135 2531301.453972426 1.0 0.6431725581068969 0.6848627039328139 21.817561196646615 -10.391525654528255 8.963727553631703 1.000001180642037 0.6640176311994654 0.9885841355677428 0.017019930762619775 4.0156636168112836e-07 2.7258440919028365e-08 0.01647953479700861 0.005493159033102476 4.059516822733509e-11 10.391525654528255 -0.3359835494425716 ISTVVSSK(ub)EVNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISTVVSSKEVNK 12 1 P37108;H0YLA2 P37108 SRP14 Signal recognition particle 14 kDa protein 1 11765100.0 5591400.0 4695500.0 1478200.0 True False 8482562.586094722 3857551.3388910466 1186033.1220819235 1.0 0.45476249656143364 0.139820143977029 23.016068738800996 -8.562719286796051 0.3135583385067032 1.1710149789433353 5.125889009441088e-16 0.998544238154979 0.013557700825823504 0.20144436270507052 0.09049011819632377 0.12686948089773886 0.09415952511204322 2.7370372826242373e-09 8.562719286796051 -1.1710149789433348 ISTVVSSK(ub)EVNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISTVVSSKEVNK 12 1 P37108;H0YLA2 P37108 SRP14 Signal recognition particle 14 kDa protein 1 13454500.0 5591400.0 6612000.0 1251100.0 True False 7238177.522971653 6244036.387584876 1023412.6373700544 1.0 0.8626531150649881 0.14139092805089 22.787195060893445 -7.001487946867421 0.712349568899941 1.0050472619914586 5.881254155252027e-22 0.9978242655920857 0.017565350880076915 0.07865364495290784 0.061701437611889315 0.016915527978516257 0.05451638954763091 9.96579738190596e-08 7.001487946867421 -1.0050472619914586 down ISVAGVTSSNVGYLAHAIHQVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISVAGVTSSNVGYLAHAIHQVTK 23 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 26657800.0 12878000.0 8981300.0 4798500.0 False True 16883182.710729387 7641325.048833203 4301997.2504622135 1.0 0.452599795889023 0.25480961286572246 24.009083561631122 -13.999999999999336 0.1416565960692614 3.618917741409304 0.014851292462905143 0.9995964131173531 0.006331906061704311 11.936049137463229 0.11803936152980186 8.63305516282987 0.2147673225046175 1.0000000000015298e-14 13.999999999999336 -3.6040664489463987 ISVAGVTSSNVGYLAHAIHQVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISVAGVTSSNVGYLAHAIHQVTK 23 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 238954000.0 108207000.0 45072000.0 85675000.0 False True 104772028.01451732 63069484.64737499 63234147.30509331 1.0 0.6019687300377159 0.6035403580842352 26.642678357355507 -10.050320171705991 5.226979166539071 1.0000043162069099 0.6027545440600847 0.9999882598675233 0.0006416144663483443 3.227277832918509e-08 5.863165573882328e-09 0.0006212472858164125 0.0002070801781228875 8.905941299388572e-11 10.050320171705991 -0.3972497721468252 ISVAGVTSSNVGYLAHAIHQVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISVAGVTSSNVGYLAHAIHQVTK 23 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 131188700.0 30050700.0 32508000.0 68630000.0 False True 45589108.900446534 26706693.413836703 55065250.41840242 1.0 0.5858130167044155 1.2078597662140982 25.442185874303206 -6.7272323716964415 1.7333736435273772 0.7499744759665721 1.207301676407299 0.5463296449556564 0.17415601621051338 0.3414690527696799 2.0086781630313535 0.07966336330794103 0.19829771206484495 1.8739915500909912e-07 6.7272323716964415 0.45732720044072694 ISVAGVTSSNVGYLAHAIHQVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISVAGVTSSNVGYLAHAIHQVTK 23 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 76516400.0 12878000.0 13793500.0 49844900.0 False True 17639344.61486435 13184057.560995208 38072561.20793911 1.0 0.747423322626468 2.1583886498739906 24.072293623154014 -6.860603850158989 1.1825725246184655 0.8627225258008284 2.22754178704098 0.954377281004469 0.13121515904818867 0.14618681211802503 0.38811346624660437 0.08651536342314493 0.2021064779620978 1.3784662894193386e-07 6.860603850158989 1.3648192612401515 up ISVAGVTSSNVGYLAHAIHQVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISVAGVTSSNVGYLAHAIHQVTK 23 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 187041000.0 108207000.0 30867500.0 47966500.0 False True 89978914.88288702 30701210.650781002 57996073.37796207 1.0 0.3412044998624453 0.6445518203175428 26.423083632789783 -10.49988282897863 6.283350742301046 1.0003653429377728 0.49287816009015856 0.7884200071655162 0.12384102499258723 0.0006342476102076952 5.04820925167968e-05 0.11999157035680479 0.03996951894779555 3.163130945914975e-11 10.49988282897863 -0.5074871828476142 ISVAGVTSSNVGYLAHAIHQVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISVAGVTSSNVGYLAHAIHQVTK 23 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 119561100.0 30050700.0 52064200.0 37446200.0 False True 38901223.537855335 49166781.50188993 30631375.830458425 1.0 1.2638877914481286 0.7874142004981051 25.213312196395655 -6.756385131454549 1.6262497308307997 1.1539692512186028 0.7859879370322058 0.675970320860908 0.11094126322383854 0.28903305988019157 1.505718313149533 0.05384964823377651 0.12986645133715993 1.7523258536463394e-07 6.756385131454549 -0.367981314186397 ISVNDFIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISVNDFIIK 9 0 P10515;H0YDD4;E9PEJ4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 9527500.0 1912400.0 3997500.0 3617600.0 False True 2507174.9197079437 3401088.5821329555 3243285.454469546 1.0 1.3565422003061287 1.293601586780132 21.25763122245329 -10.041909474763473 4.340821812568681 0.9999777406038636 1.3250718935985513 0.9726522262256524 0.025695398054975005 5847127.581627311 0.10697744933001144 1317.6754521031548 0.009145872166197843 9.080097778826625e-11 10.041909474763473 0.3250941529946877 ISVNDFIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISVNDFIIK 9 0 P10515;H0YDD4;E9PEJ4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 9080500.0 2806400.0 1152600.0 5121500.0 False True 2717312.368145697 1612839.1907295962 3780025.508293384 1.0 0.5935420637084147 1.3910897961550466 21.373748989161363 -6.768180538433045 1.5815252485738054 0.7663207278731475 1.3952578694494748 0.7234931328758007 0.17122252380576247 0.2693930661263832 1.3295295790742825 0.08535230901409747 0.2035061189292577 1.7053733092393257e-07 6.768180538433045 0.6289371415763273 ISVNDFIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISVNDFIIK 9 0 P10515;H0YDD4;E9PEJ4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 10867700.0 1912400.0 4535300.0 4420000.0 False True 2619465.960666765 4334915.449768486 3376087.032757428 1.0 1.6548851998309866 1.2888455446460816 21.320841283976183 -10.041318445097104 4.297281602920037 0.999965538677866 1.471865372150202 0.689029524494702 0.1494350637988471 104232883.035317 221919480.31334376 54247.051771596925 0.05468763618601863 9.092463260634612e-11 10.041318445097104 0.471899833472336 ISVQVATPALNLSVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISVQVATPALNLSVR 15 0 Q96BY7 Q96BY7 ATG2B Autophagy-related protein 2 homolog B 0 26327600.0 9390500.0 8946800.0 7990300.0 False True 14246075.037508039 7350173.638332552 6411013.7027271055 1.0 0.5159437682997255 0.4500196500332724 23.76406115865401 -13.999999999999998 0.28093429922335095 4.965389104707557 0.4303556923921488 0.9996072469923463 0.0048594927073702604 15.449014236867455 0.16791731959099795 35.21708282563531 0.025962657447229507 1.0000000000000041e-14 13.999999999999998 -4.535033412315409 ISVQVATPALNLSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISVQVATPALNLSVR 15 0 Q96BY7 Q96BY7 ATG2B Autophagy-related protein 2 homolog B 0 19531900.0 9390500.0 5106800.0 5034600.0 False True 12156187.364428455 4822602.090762011 4118354.4593583825 1.0 0.3967199538955736 0.3387866882843175 23.53518748074646 -13.999999999999963 0.3313633143199721 7.621312564321671 0.3286897793789866 0.9997176648306437 0.0050237223027037635 18.93912790358165 0.18414999714135466 87.4569352433889 0.018470966462448713 1.0000000000000858e-14 13.999999999999963 -7.292622784942684 ISVSAASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISVSAASK 8 0 X5D2R7;P28062-2;P28062;Q5JNW7;A0A140T998 X5D2R7 PSM8;PSMB8 Proteasome subunit beta type;Proteasome subunit beta type-8 0 3133920.0 1093700.0 637520.0 1402700.0 False True 1058981.0921611122 892085.0606228802 1035290.789902005 1.0 0.8423994226397004 0.9776291546331943 20.014245399930232 -10.164170044140496 5.761292477505215 1.000001376298759 0.910014288642461 0.3712247396774587 0.05520730690624278 9.760061303410481e-07 1.415779567833529e-07 0.05345506308974166 0.017818081686401508 6.852198821736793e-11 10.164170044140496 -0.08998708765629793 ISVSAASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISVSAASK 8 0 X5D2R7;P28062-2;P28062;Q5JNW7;A0A140T998 X5D2R7 PSM8;PSMB8 Proteasome subunit beta type;Proteasome subunit beta type-8 0 3761270.0 463830.0 2445900.0 851540.0 False True 703664.0205151335 2009410.035096078 683232.7457567598 1.0 2.855638453171221 0.9709644458680485 19.424527221996463 -6.649710687138839 2.0093184127610755 2.2043893257842195 0.9788600694665847 0.19295852573726346 0.7920613327231883 0.5092570129452045 3.940582305729152 0.31971113663005485 0.8774306038194409 2.2402129986497646e-07 6.649710687138839 -1.225529256317635 ISVSAASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISVSAASK 8 0 X5D2R7;P28062-2;P28062;Q5JNW7;A0A140T998 X5D2R7 PSM8;PSMB8 Proteasome subunit beta type;Proteasome subunit beta type-8 0 2286490.0 1093700.0 811310.0 381480.0 False True 909460.0091252269 806939.3119975735 461245.70423576847 1.0 0.8872730014525169 0.5071643608380563 19.794650675364508 -6.948798044085108 0.5718878087027333 1.004695519452926 0.37120124760581485 0.9991035465540252 0.006312685955368644 0.08397202537051897 0.03798784263442082 0.006673594133524067 0.03168533476718294 1.1251280601491282e-07 6.948798044085108 -0.633494271847111 ISVSFYHVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISVSFYHVK 9 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 199197000.0 49397000.0 60200000.0 89600000.0 False True 64759945.361228436 51218394.657762095 80329051.50388962 1.0 0.7908961993724346 1.240412589229613 25.948598432632775 -6.780217549680659 1.5350708631938688 0.8816341789163233 1.2439949712413467 0.7681488272276665 0.08843524952720797 0.25023348142005847 1.164716492280077 0.04537464988725502 0.1070435190249101 1.6587557843081046e-07 6.780217549680659 0.3623607923250234 ISVSFYHVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISVSFYHVK 9 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 181634000.0 49397000.0 50236000.0 82001000.0 False True 67660405.80373152 48016407.41176315 62634052.663606815 1.0 0.7096677420328893 0.9257120456134259 26.011808494155666 -9.778701409737698 5.890387981315252 1.0000000116649876 0.8176898945284454 0.48703623378814875 0.08819971760369016 1.3468901214659139e-08 2.808487240815222e-09 0.08539901508018263 0.028466336451244908 1.6645566888511946e-10 9.778701409737698 -0.18231011713654222 ISVSFYHVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISVSFYHVK 9 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 81012000.0 29103000.0 26648000.0 25261000.0 False True 24200433.981504526 26504441.934786163 30542958.306332573 1.0 1.0952052328913813 1.262083082050322 24.52852958350275 -6.962540391771276 0.3980171405801277 0.9906234611139275 1.3727387098609243 0.9998531192631375 0.0013127695794183083 0.07880584636651393 0.017867642221474987 0.0021479381025464837 0.013992108527239778 1.0900831039566797e-07 6.962540391771276 0.38211524874699676 ISVYSIMGGSTDGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISVYSIMGGSTDGLR 15 0 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;O94979-5 D6REX3 SEC31A Protein transport protein Sec31A 0 17318400.0 3468200.0 5633400.0 8216800.0 False True 4546843.78609658 4792918.678821213 7366604.357111175 1.0 1.0541199355643325 1.620157784975351 22.116434008221848 -6.925473431225794 0.7830500168200889 0.9897972425004901 1.7240147174534333 0.9955714847384154 0.018663838156516677 0.09505710256751974 0.08969875064123327 0.016566227834719626 0.05254882020805022 1.1872073284426084e-07 6.925473431225794 0.7342174749529432 ISVYSIMGGSTDGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISVYSIMGGSTDGLR 15 0 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;O94979-5 D6REX3 SEC31A Protein transport protein Sec31A 0 18846200.0 7949000.0 3442800.0 7454400.0 False True 7696663.346062619 4817527.993964826 5501869.012793554 1.0 0.6259242190226921 0.7148382052604839 22.875801714174514 -10.00685218076287 5.806151059155879 1.0000005644762513 0.670381212141506 0.9482511278685593 0.03629898288020577 2.6526726307985034e-07 4.532621205551358e-08 0.03514639900879322 0.011715446348231672 9.84346087056035e-11 10.00685218076287 -0.32961935233474526 ISVYSIMGGSTDGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISVYSIMGGSTDGLR 15 0 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;O94979-5 D6REX3 SEC31A Protein transport protein Sec31A 0 17389800.0 3468200.0 5690300.0 8231300.0 False True 4750487.264580885 5438883.730694248 6287236.468944841 1.0 1.1449107065807695 1.323492963726435 22.17964406974474 -6.968317264556602 0.2956307663098414 0.967374830851082 1.5065900356039486 0.9999661179488752 0.0007700956111048477 0.07685261365848495 0.010974280652773909 0.003028869573862178 0.016092018433489962 1.0756791121326446e-07 6.968317264556602 0.5392152047528666 ISVYSIMGGSTDGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISVYSIMGGSTDGLR 15 0 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;O94979-5 D6REX3 SEC31A Protein transport protein Sec31A 0 14955000.0 7949000.0 3072000.0 3934000.0 False True 6609945.700408186 3055450.526255742 4756581.211239152 1.0 0.46225047296032373 0.7196097255300323 22.65620698960879 -10.429493594814078 6.111566051010916 1.0001333859074104 0.5909300992451813 0.7710956523054018 0.10506647489664131 0.0001910155132676288 1.7830823635490885e-05 0.10176298700910047 0.033910058959950924 3.719687070966297e-11 10.429493594814078 -0.40920328666222916 ISVYYNEASSHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISVYYNEASSHK 12 0 A0A0B4J269;Q13509;G3V5W4;G3V2R8;G3V3R4;G3V2N6 A0A0B4J269 TUBB3 Tubulin beta-3 chain 0 8911300.0 3043800.0 1754100.0 4113400.0 False True 3990451.2762011318 1492395.1174282467 3687784.8265189715 1.0 0.3739915648961366 0.9241523254557075 21.928120477957894 -10.434211339575057 8.70627575527186 1.0000041620375317 0.6490719451759325 0.3516996558219875 0.22460218997874348 1.8145197553008782e-05 1.179001211193894e-06 0.2174727149326638 0.07249004510911566 3.679498755942961e-11 10.434211339575057 -0.35093221686159926 ISVYYNEASSHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISVYYNEASSHK 12 0 A0A0B4J269;Q13509;G3V5W4;G3V2R8;G3V3R4;G3V2N6 A0A0B4J269 TUBB3 Tubulin beta-3 chain 0 5320700.0 1104900.0 795000.0 3420800.0 False True 1069825.5542916816 1112447.6458702318 2524789.8581997473 1.0 1.0398402257335961 2.360001448901059 20.028944139337522 -6.913341885836937 0.8726621792591217 0.9633175146939027 2.543395422135951 0.9921228870102345 0.0560857245020009 0.10224956900259116 0.12708502271758773 0.04669074165132679 0.13207764254694754 1.2208382120174325e-07 6.913341885836937 1.5800779074420483 up ISVYYNEASSHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISVYYNEASSHK 12 0 A0A0B4J269;Q13509;G3V5W4;G3V2R8;G3V3R4;G3V2N6 A0A0B4J269 TUBB3 Tubulin beta-3 chain 0 7183500.0 3043800.0 1650500.0 2489200.0 False True 4169175.115602126 1577575.4525263803 1901302.2266832103 1.0 0.37839030714317734 0.45603798688331615 21.991330539480785 -10.577659312544608 6.426581715510547 1.0011253874328268 0.41721414701432014 0.9868611816647298 0.031699532512397204 0.0005119809086942196 3.3646225114276845e-05 0.030743653201714204 0.01023098012525624 2.6444824394563657e-11 10.577659312544608 -0.5839112404185066 ISVYYNEASSHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISVYYNEASSHK 12 0 A0A0B4J269;Q13509;G3V5W4;G3V2R8;G3V3R4;G3V2N6 A0A0B4J269 TUBB3 Tubulin beta-3 chain 0 2006500.0 1104900.0 0.0 901600.0 False True 918773.3053693541 0.0 1090120.3914726046 1.0 0.0 1.1864954990549792 19.8093494147718 -10.758515068215921 6.199730045120259 1.0129475792352316 0.5932477495274896 0.1354709203578809 0.48438475913226325 0.08649174956888535 0.00336892537584684 0.46794754025467616 0.1563345087729956 1.7437528554298706e-11 10.758515068215921 -0.419699829707742 ISVYYNEATGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISVYYNEATGGK 12 0 P07437;Q5JP53 P07437 TUBB Tubulin beta chain 0 854480000.0 230490000.0 258010000.0 365980000.0 False True 302174622.06833524 219515913.71510303 328111900.3280532 1.0 0.7264538372301187 1.0858353957131859 28.170807260920103 -6.703253982070522 1.819453557909116 0.8306785632067353 1.0848263724246598 0.43290521405336957 0.11540059021391036 0.3888144636378926 2.5046119712616317 0.05055924564514724 0.12949624632659343 1.980368537208608e-07 6.703253982070522 0.25414780921792457 ISVYYNEATGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISVYYNEATGGK 12 0 P07437;Q5JP53 P07437 TUBB Tubulin beta chain 0 418922000.0 108590000.0 35582000.0 274750000.0 False True 105142869.8891609 49790078.157678716 202784732.67667776 1.0 0.47354688159231556 1.928658908497063 26.64777577821923 -6.808855804146267 1.4195884163650134 0.7127006164201161 1.9533929820821048 0.8567519473460533 0.22768062332252492 0.20836979631108385 0.8278661372515407 0.12612628384270633 0.2918762690644405 1.5529025240734944e-07 6.808855804146267 1.2406923656619888 ISVYYNEATGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISVYYNEATGGK 12 0 P07437;Q5JP53 P07437 TUBB Tubulin beta chain 0 702844000.0 111200000.0 517460000.0 74184000.0 False True 168698529.80894473 425115220.06656635 59521499.88399779 1.0 2.5199699164421876 0.3528276147480797 27.329872159834117 -6.718169782551727 1.7656884439203995 1.9265289199872637 0.35650253801117204 0.5039343670652923 0.6397575913036133 0.3589003373122926 2.1857030422047683 0.28779127744901617 0.724081614333142 1.9135077144210024e-07 6.718169782551727 -1.5700263819760916 ISVYYNEATGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISVYYNEATGGK 12 0 P07437;Q5JP53 P07437 TUBB Tubulin beta chain 0 620640000.0 230490000.0 152230000.0 237920000.0 False True 315708381.7580439 145503975.24270868 181728196.11620983 1.0 0.4608809383914984 0.5756204352391402 28.234017322442995 -9.739429361487254 6.107389352072379 1.0000000096388526 0.518250686814146 0.9591915330055876 0.04684220344141492 6.141194308223529e-09 1.327910230186418e-09 0.045354769130842486 0.015118256151668228 1.822093414646762e-10 9.739429361487254 -0.4817493228247066 ISVYYNEATGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISVYYNEATGGK 12 0 P07437;Q5JP53 P07437 TUBB Tubulin beta chain 0 273245000.0 108590000.0 102830000.0 61825000.0 False True 90297396.35266387 102276034.37984319 74752321.65349802 1.0 1.1326576237081716 0.8278458147513658 26.428181053653507 -6.788418867513208 1.502673652161824 1.0742944921913309 0.8247447560514682 0.7961592854767343 0.05633957315924653 0.23771244622906548 1.0604206613728056 0.029514268114055837 0.06917969068503363 1.6277253698677711e-07 6.788418867513208 -0.24954973613986264 ISVYYNEATGGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISVYYNEATGGK 12 0 P07437;Q5JP53 P07437 TUBB Tubulin beta chain 0 321699000.0 111200000.0 143640000.0 66859000.0 False True 143950592.07970244 135646307.73029214 54691348.0312721 1.0 0.9423115651736091 0.37993138646481317 27.100998481926567 -6.926614994863091 0.7740746063689827 1.0097105064510428 0.2738379694038353 0.9958300715588764 0.018061566652484064 0.09443401025763076 0.08657346645741847 0.01613493497365176 0.05186506210544162 1.1840907954613799e-07 6.926614994863091 -0.7358725370472075 down ISVYYNEATGGK(ub)YVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISVYYNEATGGKYVPR 16 1 P07437;Q5JP53 P07437 TUBB Tubulin beta chain 1 382770000.0 117560000.0 135060000.0 130150000.0 True False 154122298.45265952 114909574.4597567 116683326.48695579 1.0 0.7455739734834835 0.7570827041798657 27.199500365531655 -9.720280595882366 5.681286378995511 1.0000000133405522 0.7513283388297743 0.9983961377003375 0.004698419649312793 7.915432631468388e-10 1.8494500894676857e-10 0.0045492254936099685 0.0015164084187831723 1.9042300052356206e-10 9.720280595882366 -0.24867167451077787 ISVYYNEATGGK(ub)YVPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISVYYNEATGGKYVPR 16 1 P07437;Q5JP53 P07437 TUBB Tubulin beta chain 1 510458000.0 243120000.0 224610000.0 42728000.0 True False 368830814.45279276 184526590.61406007 34282792.07165231 1.0 0.500301448206893 0.09294991288218468 28.45838395174554 -8.025954063693646 0.4284607912312886 1.05095171985088 3.089662327931031e-16 0.9966113803589652 0.02159315067106218 0.09866082586631585 0.09940063510059263 0.046650148710432 0.08071609528443181 9.419892275777157e-09 8.025954063693646 -1.0509517198508798 down ISVYYNEATGGK(ub)YVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISVYYNEATGGKYVPR 16 1 P07437;Q5JP53 P07437 TUBB Tubulin beta chain 1 382980000.0 117560000.0 126710000.0 138710000.0 True False 161025108.93954462 121111533.22606334 105949554.82212298 1.0 0.7521282489647844 0.65796915474779 27.262710427054547 -13.999999999999998 0.13419067320131436 2.179410284576877 0.5328641641220185 0.9996270737570033 0.002785789192725833 11.932505790840299 0.1143106455735345 3.6991286181174137 0.1114627900548943 1.0000000000000041e-14 13.999999999999998 -1.6465461204548584 ISVYYNEATGGK(ub)YVPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISVYYNEATGGKYVPR 16 1 P07437;Q5JP53 P07437 TUBB Tubulin beta chain 1 1273030000.0 243120000.0 250260000.0 779650000.0 True False 314723632.6116653 236332811.00377968 637761699.8845527 1.0 0.750921718342609 2.026418208865431 28.229510273837988 -6.856029991024803 1.2055911681547355 0.8660398659651529 2.0836735006571994 0.9486352461610138 0.12510709704064804 0.150946662460784 0.41916419303288044 0.08105668804898285 0.18844827162549793 1.3930605991957011e-07 6.856029991024803 1.2176336346920464 up ISWYLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ISWYLR 6 0 Q13011;M0R248;M0QZW4;M0QYT0;M0R076 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 60954000.0 15842000.0 16484000.0 28628000.0 False True 20769015.414146226 14024651.45412875 25665849.179166883 1.0 0.675267997758635 1.2357759223234683 24.307929488925755 -6.749637380966081 1.6511384859829403 0.8089655324366062 1.2368601944795532 0.6473675263848893 0.13645291441717614 0.30070944617248313 1.6128603482217596 0.06528551384146856 0.15855897016909618 1.7797648243622973e-07 6.749637380966081 0.427894662042947 ISWYLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISWYLR 6 0 Q13011;M0R248;M0QZW4;M0QYT0;M0R076 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 53923100.0 21856000.0 5060100.0 27007000.0 False True 21162193.24336956 7080624.318072898 19933056.507366862 1.0 0.33458839717813116 0.9419182727486053 24.334985819894083 -10.692728092958085 9.687400889060473 1.0003817142653004 0.6382533349633812 0.32113213623303927 0.2479413834492767 0.002046083375683685 6.489883371425122e-05 0.24030410934272453 0.08002273741122301 2.028952627069216e-11 10.692728092958085 -0.3621283793019192 ISWYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISWYLR 6 0 Q13011;M0R248;M0QZW4;M0QYT0;M0R076 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 21059900.0 6942800.0 6804200.0 7312900.0 False True 10532735.18666853 5589937.348542752 5867502.109642067 1.0 0.5307203921368909 0.5570729735110657 23.328376794576663 -10.658821615327868 6.603001473059858 1.0025483663047032 0.5438966828239786 0.9975025588032562 0.010758396295316672 0.0004052471205032079 2.0939153423618855e-05 0.010459248315164253 0.003472257473638419 2.193705805960133e-11 10.658821615327868 -0.4586516834807246 ISWYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISWYLR 6 0 Q13011;M0R248;M0QZW4;M0QYT0;M0R076 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 52385000.0 15842000.0 16839000.0 19704000.0 False True 21699215.51395257 16094997.30087348 15050321.016618188 1.0 0.741731759405054 0.6935882546970812 24.371139550448646 -13.999999999999998 0.2362258144136159 2.6787600118125443 0.6715252603900242 0.9995188978982926 0.002950994040420264 13.493248835468547 0.15385109140525263 10.662196906739652 0.024058060229835233 1.0000000000000041e-14 13.999999999999998 -2.00723475142252 ISWYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISWYLR 6 0 Q13011;M0R248;M0QZW4;M0QYT0;M0R076 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 45848000.0 21856000.0 11582000.0 12410000.0 False True 18174232.38496935 11519605.467153005 15004873.622643089 1.0 0.633842751822634 0.8256125103282261 24.11539109532836 -10.033972659405238 4.849041429813512 1.0000054713260915 0.7297276310715969 0.7259064262913875 0.07828967608773907 108280235.14157753 25.514916753832292 6759.608979718837 0.026800638505848184 9.247563892619637e-11 10.033972659405238 -0.27027784025449464 ISWYLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISWYLR 6 0 Q13011;M0R248;M0QZW4;M0QYT0;M0R076 Q13011;M0QYT0 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 39338800.0 6942800.0 19018000.0 13378000.0 False True 8987591.463048177 17959631.5818344 10943341.269871794 1.0 1.9982696872320138 1.2176055525959917 23.099503116669112 -10.208418313771158 4.712723546425407 0.999886935942675 1.607937619916745 0.4470830602556545 0.3187047984013166 0.00037870036846013473 6.360886597364051e-05 0.30864151402697715 0.10286153137901545 6.188447147958314e-11 10.208418313771158 0.60805068397407 ISYFTFIGTPVQATNMNDFK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ISYFTFIGTPVQATNMNDFK 20 0 O43396;K7ER96;K7EME7 O43396 TXNL1 Thioredoxin-like protein 1 0 25144100.0 10975800.0 5232600.0 8935700.0 False True 10627379.236849178 7322004.467648526 6595172.104746095 1.0 0.6889755512121317 0.6205831144030428 23.341282529362353 -13.999999999999968 0.2128430919936471 2.8201186928743662 0.5813930152653768 0.9994917970035084 0.0037222742443550638 12.81475768423368 0.14620776202212662 9.767557311821943 0.03972019844961193 1.0000000000000737e-14 13.999999999999968 -2.2387256776089894 ISYFTFIGTPVQATNMNDFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISYFTFIGTPVQATNMNDFK 20 0 O43396;K7ER96;K7EME7 O43396 TXNL1 Thioredoxin-like protein 1 0 9925900.0 1822200.0 2548400.0 5555300.0 False True 2495916.5831034197 2435803.2615681426 4243252.554994873 1.0 0.9759153322902593 1.7000778726822743 21.251138287517104 -6.899208577790014 0.9662791558066551 0.9692336917125787 1.7748749824944277 0.9861674668696866 0.03949881964328768 0.11199025820045107 0.18073433633211275 0.030703748945282237 0.07957154201724417 1.2612216645671385e-07 6.899208577790014 0.805641290781849 ISYFTFIGTPVQATNMNDFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISYFTFIGTPVQATNMNDFK 20 0 O43396;K7ER96;K7EME7 O43396 TXNL1 Thioredoxin-like protein 1 0 15924700.0 8296300.0 3591100.0 4037300.0 False True 6898741.038406901 3571754.031522461 4881480.763633922 1.0 0.5177399777202352 0.7075900858515458 22.717901675654634 -10.149359348110346 5.288571092864119 1.0000122860744993 0.6126650317856965 0.8473274895482797 0.0775059820896663 1.1227932682132038e-05 1.8060878883958023e-06 0.07504722244032472 0.025014948155295997 7.089908851487892e-11 10.149359348110346 -0.3873472542888028 ISYFTFIGTPVQATNMNDFK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISYFTFIGTPVQATNMNDFKR 21 1 O43396;K7ER96;K7EME7 O43396 TXNL1 Thioredoxin-like protein 1 1 9485200.0 4046200.0 3274700.0 2164300.0 True False 3917755.5957779065 4582304.787334907 1597404.902391754 1.0 1.169624974123749 0.40773469996782036 21.901595969033494 -6.848279405700309 1.2433078364619936 1.0904056963433548 0.3782645450605419 0.9377681497113698 0.08147548646371393 0.15936378015721325 0.47491260882659797 0.05129888725424559 0.11858967814839266 1.418144856984358e-07 6.848279405700309 -0.7121411512828129 down ISYFTFIGTPVQATNMNDFK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ISYFTFIGTPVQATNMNDFKR 21 1 O43396;K7ER96;K7EME7 O43396 TXNL1 Thioredoxin-like protein 1 1 35178400.0 8145800.0 9176600.0 17856000.0 True False 12357774.137749113 7538964.032896949 14326753.773437172 1.0 0.610058409294582 1.1593312528405455 23.55891557496067 -6.716035712904906 1.7736876390069785 0.7617662752434529 1.158285180898292 0.4937284765019495 0.1641732559795552 0.36306158883078876 2.229986044039238 0.07355906967693697 0.1855198465363364 1.9229335957282593e-07 6.716035712904906 0.39651890565483905 ISYFTFIGTPVQATNMNDFK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISYFTFIGTPVQATNMNDFKR 21 1 O43396;K7ER96;K7EME7 O43396 TXNL1 Thioredoxin-like protein 1 1 10778100.0 4046200.0 4610600.0 2121300.0 True False 3364594.577052662 4585761.782667555 2564854.0222169873 1.0 1.362946315714691 0.7623070071235042 21.68200124446777 -6.743103444702035 1.6752510670173333 1.215173151690261 0.7617060982276147 0.6188025874466023 0.152488866285231 0.31224259278470706 1.7217411498464052 0.07197422571902928 0.17602587041337855 1.8067437260528397e-07 6.743103444702035 -0.4534670534626464 ISYFTFIGTPVQATNMNDFK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ISYFTFIGTPVQATNMNDFKR 21 1 O43396;K7ER96;K7EME7 O43396 TXNL1 Thioredoxin-like protein 1 1 25076900.0 8145800.0 8130500.0 8800600.0 True False 10544898.677723378 7678030.527716095 7198981.101781561 1.0 0.7281274825272921 0.6826979871309495 23.330041897053118 -13.999999999999998 0.251748095518066 2.9075304845953642 0.6647328573960374 0.9995460003194522 0.0029852016956170963 14.068074319492839 0.15876843827897083 13.584671981147173 0.02076377915773439 1.0000000000000041e-14 13.999999999999998 -2.2427976271993266 ISYFTFIGTPVQATNMNDFKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ISYFTFIGTPVQATNMNDFKR 21 1 O43396;K7ER96;K7EME7 O43396 TXNL1 Thioredoxin-like protein 1 0 15314100.0 6685500.0 4614400.0 4014200.0 False True 6473272.4619576875 6456953.983778101 2962760.5965813287 1.0 0.9974790991302332 0.45769131671700286 22.626063797937803 -6.90792465021767 0.9097516240538329 1.017829566542747 0.3909429861492993 0.9901145376829166 0.02535897776149587 0.10580644912384336 0.14632992133189132 0.02055100196416219 0.055946559757312865 1.2361618880445158e-07 6.90792465021767 -0.6268865803934478 down ISYFTFIGTPVQATNMNDFKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ISYFTFIGTPVQATNMNDFKR 21 1 O43396;K7ER96;K7EME7 O43396 TXNL1 Thioredoxin-like protein 1 0 16020100.0 2375400.0 6206800.0 7437900.0 False True 3253649.572771299 5932563.052857148 5681221.208358939 1.0 1.823356486360663 1.7461072808526068 21.63362744637974 -10.078667419994028 4.414302753069317 0.9999337111759194 1.784731883668584 0.9927845777316182 0.0315368563069236 4623818.940282231 3519012.2514303112 2658.488400215835 0.010795904338228504 8.343198569864081e-11 10.078667419994028 0.7847981724926645 ISYFTFIGTPVQATNMNDFKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ISYFTFIGTPVQATNMNDFKR 21 1 O43396;K7ER96;K7EME7 O43396 TXNL1 Thioredoxin-like protein 1 0 14807800.0 6685500.0 4069400.0 4052900.0 False True 5559289.467867523 4047477.3344873423 4900342.651507668 1.0 0.7280565903037796 0.8814692380800564 22.40646907337208 -10.14800174428824 5.012797543076251 1.000010463265173 0.8047629144389871 0.6834881599065894 0.06263045119156123 7.324178001000446e-06 1.2448624311850243e-06 0.06064492320877876 0.02021389120233624 7.112106571609515e-11 10.14800174428824 -0.1952475488261859 ITAASQEHGLK(ub)YPALIGNLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITAASQEHGLKYPALIGNLVK 21 1 Q9BYC9;I3L2X1;Q9BYC9-2 Q9BYC9 MRPL20 39S ribosomal protein L20, mitochondrial 1 11730700.0 4358400.0 4013200.0 3359100.0 True False 5713904.6068056375 3414446.20333108 3011532.554762453 1.0 0.5975679396649796 0.5270533482787793 22.446045520117668 -13.999999999999998 0.24500499673019502 3.729791711038631 0.4973222011183871 0.9995335554148298 0.004499309545139519 13.805421744270276 0.1566404132853624 18.49236642994051 0.03347112647492918 1.0000000000000041e-14 13.999999999999998 -3.232469509920244 ITAASQEHGLK(ub)YPALIGNLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITAASQEHGLKYPALIGNLVK 21 1 Q9BYC9;I3L2X1;Q9BYC9-2 Q9BYC9 MRPL20 39S ribosomal protein L20, mitochondrial 1 34284000.0 6666000.0 10233000.0 17385000.0 True False 10112809.349877916 8406841.199206078 13948847.129883822 1.0 0.8313062086261487 1.379324641381894 23.26968049944613 -6.824045892099844 1.3541640342443877 0.9094270622895753 1.3923708522255451 0.8934630571607884 0.07480100117446273 0.18827296651966421 0.6772411247191059 0.043393282853239484 0.09992888854106821 1.499526371481104e-07 6.824045892099844 0.48294378993596987 ITADLLSNGIDVYPQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITADLLSNGIDVYPQK 16 0 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4 Q9UHD8 SEPT9 Septin-9 0 3735450.0 701450.0 1608500.0 1425500.0 False True 919607.7428514637 1368518.0698838911 1278002.9343615484 1.0 1.4881541401994656 1.389726156935994 19.81065908765078 -9.999755104721974 4.7090666963452446 0.999991755917041 1.4389401485614284 0.9636578434092187 0.04018305597012249 27693262.005790222 1.2541896784110156 2568.643533539608 0.013755728854834944 1.000564051233632e-10 9.999755104721974 0.43894839264438734 ITADLLSNGIDVYPQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITADLLSNGIDVYPQK 16 0 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4 Q9UHD8 SEPT9 Septin-9 0 5044250.0 701450.0 1843800.0 2499000.0 False True 960795.0209734912 1762334.819368761 1908787.668520545 1.0 1.8342464114594788 1.986675229214379 19.87386914917367 -10.970804845024182 0.3200155188843405 2.436296454830353e-13 2.0234111865385276 0.9992758677505843 0.011670284262950867 2.806260225899013 0.16166030619840882 2.128561061360883 0.050554912631662244 1.0695353786768694e-11 10.970804845024182 2.023411186538284 ITADLLSNGIDVYPQK(ub)EFDEDSEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITADLLSNGIDVYPQKEFDEDSEDR 25 1 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4 Q9UHD8 SEPT9 Septin-9 1 9293300.0 3205900.0 3415100.0 2672300.0 True False 3104130.4593209396 4778767.239511228 1972344.4627184216 1.0 1.5394865976595045 0.6353935469419324 21.5657577612114 -6.745090137371173 1.6681792874759847 1.3190865243390568 0.6342651825848152 0.6275255486780185 0.22666123201537308 0.3086800656731943 1.6884899423042499 0.10741142853267806 0.2621076476431978 1.7984976000701705e-07 6.745090137371173 -0.6848213417542416 ITAEEMYDIFGK(ub)YGPIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITAEEMYDIFGKYGPIR 17 1 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 1 7586400.0 2284800.0 2173300.0 3128300.0 True False 2212270.2746362914 3041110.0236097807 2308904.383011654 1.0 1.37465573645144 1.0436809685883655 21.07709622074573 -10.532846307446926 6.535509424776562 0.9998148991096154 1.2091683525199008 0.347482573641019 0.1351198831667741 0.0003647454249799134 2.6071797210533246e-05 0.13094402522610898 0.043609754770534005 2.931930643144808e-11 10.532846307446926 0.20935345341028544 ITAEEMYDIFGK(ub)YGPIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITAEEMYDIFGKYGPIR 17 1 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 1 29185000.0 3535000.0 11198000.0 14452000.0 True False 5362853.4431170765 9199629.409626668 11595555.865463387 1.0 1.7154355432617463 2.1621989093037097 22.354569397032645 -8.760875449951916 0.13883336280171363 1.3656284976776105e-12 3.049279189121396 0.9999003017814027 0.004779499783424767 0.3020958086785245 0.04033943761384882 0.4675500225300517 0.3468332853131787 1.7343013016537265e-09 8.760875449951916 3.0492791891200306 ITAEEMYDIFGK(ub)YGPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITAEEMYDIFGKYGPIR 17 1 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 1 6999400.0 2284800.0 2448900.0 2265700.0 True False 1899912.433802067 2435707.2896314096 2739447.3945868243 1.0 1.2820102896832568 1.441880870848714 20.857501496180006 -11.401183520967152 0.08794185194079925 1.3519394695126935e-22 1.9225072180224712 0.9999181032111867 0.0016531842635039227 4.248026479516302 0.058953515709309734 1.1629413180492716 0.33035833103817835 3.9702374264430214e-12 11.401183520967152 1.9225072180224712 ITAEEMYDIFGK(ub)YGPIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITAEEMYDIFGKYGPIR 17 1 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 1 27951000.0 3535000.0 10524000.0 13892000.0 True False 4576127.185267514 9938330.148660494 11363798.543957148 1.0 2.1717775197892615 2.483278563703827 22.125695719125094 -10.319907157338307 0.29430059955016113 7.23553599292665e-14 2.591785786739225 0.9990209159944183 0.019981781553427672 1.8214496593380336 0.1392730024105984 1.5259199470725064 0.11409221856008772 4.7873242390590435e-11 10.319907157338307 2.5917857867391527 ITAFVVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITAFVVER 8 0 P49748-2;P49748;P49748-3 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 13522000.0 4525400.0 4247000.0 4749600.0 False True 5932843.224035937 3613364.154676335 4258156.953380296 1.0 0.6090442673484755 0.7177261883693596 22.500292229267828 -10.250304668363894 8.041832474308062 1.0000003149262828 0.6633852278589192 0.9274867677701473 0.04436920846110452 2.5049792573104647e-07 2.3403486332529925e-08 0.04296034169209738 0.01432010045452192 5.619469671282609e-11 10.250304668363894 -0.33661508706736365 ITAHLVHELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITAHLVHELR 10 0 P42765;A0A0B4J2A4;K7EME0 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 82925000.0 29626000.0 27310000.0 25989000.0 False True 38839972.89859211 23235454.453546204 23299907.584091388 1.0 0.5982355990363849 0.5998950525770315 25.21103885829819 -9.970941951480249 5.090133730065462 1.00000230950585 0.5990653258025568 0.999987150974088 0.0006774690862820758 931102.4005823949 0.15676858121703408 25.291944100240016 0.00023191568554115565 1.0691977804184282e-10 9.970941951480249 -0.4009369837032931 ITAHLVHELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITAHLVHELR 10 0 P42765;A0A0B4J2A4;K7EME0 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 60633900.0 16239000.0 7021900.0 37373000.0 False True 15723501.833779206 9825781.288724745 27583890.13403273 1.0 0.6249104933874059 1.754309595002148 23.90641922503979 -6.817192445871484 1.3840910675015616 0.7972406400252677 1.7774902886280508 0.8777821590942847 0.1641912801262519 0.19715295700136606 0.7428989292631734 0.09324094781556296 0.21507109675089003 1.5233775605845296e-07 6.817192445871484 0.9802496486027831 ITAHLVHELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITAHLVHELR 10 0 P42765;A0A0B4J2A4;K7EME0 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 60144000.0 12993000.0 25317000.0 21834000.0 False True 19711330.91553614 20798983.54737618 17518500.32981785 1.0 1.0551790559704302 0.8887527891893927 24.23252185512461 -6.817335398808498 1.3832704404533065 1.0298244292861987 0.8853205318390641 0.8781564036948177 0.024160797671888945 0.19697326393101072 0.7412739326722955 0.013727673570600493 0.031666187948875275 1.522876206161367e-07 6.817335398808498 -0.14450389744713454 ITAHLVHELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITAHLVHELR 10 0 P42765;A0A0B4J2A4;K7EME0 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 67784000.0 29626000.0 14273000.0 23885000.0 False True 40579532.81254633 13642371.665500766 18243854.9270161 1.0 0.33618848517848965 0.44958267536721097 25.27424891982108 -9.93211469517763 5.753406759101796 1.000000435804805 0.3928855802757531 0.9745032358143817 0.04629298429497612 2.587033246274499e-07 4.8061443717035997e-08 0.044823021362707514 0.01494099643478051 1.169190572383679e-10 9.93211469517763 -0.6071148555290518 ITAHLVHELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITAHLVHELR 10 0 P42765;A0A0B4J2A4;K7EME0 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 45086000.0 16239000.0 18533000.0 10314000.0 False True 13503448.009677768 18433159.050487533 12470609.71345213 1.0 1.365070538819174 0.9235129949413354 23.686824500474067 -6.687159961491264 1.8767996855316877 1.2294850070999448 0.9251007103642401 0.3570688152443031 0.15448955235654338 0.42278236437567535 2.8850971197150685 0.0659108301834851 0.1722348382416889 2.0551334996302582e-07 6.687159961491264 -0.30438429673570466 ITAHLVHELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITAHLVHELR 10 0 P42765;A0A0B4J2A4;K7EME0 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 69159000.0 12993000.0 31348000.0 24818000.0 False True 16819694.630319905 29603456.242893334 20301378.654184308 1.0 1.76004718834365 1.2070004301735757 24.00364817721706 -10.09444391185943 5.181507998695623 0.9999901764020762 1.4835238092594079 0.5047493779071937 0.22578039357228738 2.56227556835775e-05 4.4777042775378825e-06 0.21861536310029467 0.07287030868340323 8.045556483674542e-11 10.09444391185943 0.48353363285733164 ITAK(ub)GDINQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITAKGDINQK 10 1 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4;F5GYR7;F5H592 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 1773970.0 452430.0 622590.0 698950.0 True False 593140.111338352 529701.9988368128 626629.3588018276 1.0 0.8930470030792582 1.0564609386944193 19.178013412355913 -6.730168125628899 1.7231268208584576 0.9356463902236027 1.0563574941550429 0.5598349889607632 0.04495975225671817 0.3359155287178966 1.9541535731690745 0.02067847692407217 0.051292482230368655 1.861366418361251e-07 6.730168125628899 0.12071110393144013 ITAK(ub)GDINQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITAKGDINQK 10 1 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4;F5GYR7;F5H592 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 1997850.0 485140.0 674250.0 838460.0 True False 469739.4962522105 943481.5411672989 618842.1727391711 1.0 2.008520783742504 1.3174156690603358 18.841501376637183 -10.505050020517622 5.001236539419387 0.9977811354514949 1.662968226401443 0.5509605190110313 0.2821424815999076 0.006999121247692052 0.0006926709194414966 0.27391716685382284 0.09106109437449475 3.125719336983194e-11 10.505050020517622 0.665187090949948 ITASLCDLK(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITASLCDLKSR 11 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 6836500.0 0.0 2988000.0 3848500.0 True False 0.0 2542202.0471327766 3450294.137418749 0.0 ITASLCDLK(ub)SR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITASLCDLKSR 11 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 8134000.0 0.0 0.0 8134000.0 True False 0.0 0.0 6212916.724988445 0.0 ITDFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITDFIK 6 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 9729400.0 3568100.0 1371000.0 4790300.0 False True 3454832.6185791986 1918447.4496705504 3535576.7240804015 1.0 0.5552938916211555 1.0233713509207312 21.720184385235736 -10.963237041885165 12.835969144146775 1.0710737275223798 0.7893326212714197 0.21265011889970153 0.19109182256372018 0.09637067828594027 0.00027601087541924017 0.045876571419925675 0.0616746205321426 1.088335907537798e-11 10.963237041885165 -0.28174110625096016 ITDHYK(ub)EYSQMQQQNTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITDHYKEYSQMQQQNTQK 18 1 Q8WUB8-3;Q8WUB8-2;Q8WUB8;S5FZ81 Q8WUB8-3 PHF10 PHD finger protein 10 1 4411260.0 1188800.0 2278100.0 944360.0 True False 1558528.3123555777 1938216.3599642494 846646.6861407731 1.0 1.2436196022867283 0.5432347166418436 20.571752932644195 -6.8127214690396425 1.402812632995813 1.1323486322704766 0.530172215137457 0.8668931906890499 0.10591648292272546 0.20309757937189396 0.7871479125125616 0.05935672966478734 0.13715909910630203 1.539141438706569e-07 6.8127214690396425 -0.6021764171330195 ITDHYK(ub)EYSQMQQQNTQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITDHYKEYSQMQQQNTQK 18 1 Q8WUB8-3;Q8WUB8-2;Q8WUB8;S5FZ81 Q8WUB8-3 PHF10 PHD finger protein 10 1 5903020.0 1645700.0 2061420.0 2195900.0 True False 1593458.1543106372 2884555.756163288 1620727.9144120745 1.0 1.8102488279092626 1.0171135715284816 20.603729702427255 -10.246909245958566 4.082878576316668 0.9996680291099546 1.4136811991859142 0.2661754641190388 0.32379611277346465 44406874.66589375 55725085.171094455 111729.33286680763 0.11084402412262108 5.663576278054128e-11 10.246909245958566 0.4140131700759596 ITDHYK(ub)EYSQMQQQNTQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITDHYKEYSQMQQQNTQK 18 1 Q8WUB8-3;Q8WUB8-2;Q8WUB8;S5FZ81 Q8WUB8-3 PHF10 PHD finger protein 10 1 11754900.0 4432200.0 4073500.0 3249200.0 True False 6723971.437223051 3346552.098599234 2606994.1958250473 1.0 0.4977046868571076 0.3877164292211384 22.680882165483 -13.999999999999869 0.2134379068007611 3.946789875285204 0.3250520453549563 0.9994922188756862 0.00600572572529133 12.829393612573243 0.1464075967977993 15.88077348917085 0.06361721867783239 1.0000000000003026e-14 13.999999999999869 -3.621737829930248 ITDHYK(ub)EYSQMQQQNTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITDHYKEYSQMQQQNTQK 18 1 Q8WUB8-3;Q8WUB8-2;Q8WUB8;S5FZ81 Q8WUB8-3 PHF10 PHD finger protein 10 1 4585790.0 1188800.0 1910890.0 1486100.0 True False 1628331.4861120342 1826460.561331798 1135113.7871902287 1.0 1.1216761310025618 0.6971024001387697 20.634962994167086 -6.830084356839437 1.3274457625330434 1.0650141527699442 0.6856512192067012 0.9060516735509433 0.054717231315278905 0.18071348088179434 0.6227379559623942 0.03236304775219006 0.074479737836912 1.47882111582899e-07 6.830084356839437 -0.3793629335632429 ITDHYK(ub)EYSQMQQQNTQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITDHYKEYSQMQQQNTQK 18 1 Q8WUB8-3;Q8WUB8-2;Q8WUB8;S5FZ81 Q8WUB8-3 PHF10 PHD finger protein 10 1 6355400.0 1645700.0 3675800.0 1033900.0 True False 1368472.4668715252 3655997.7358108275 1250083.7097865173 1.0 2.6715902762507384 0.9134883894626998 20.38413497786153 -6.657589264577124 1.9813362742750587 2.0781123081641346 0.9208361788995834 0.22542708222840957 0.7121379623156125 0.49020324946861876 3.6967314377443765 0.2906347998186594 0.7892989361739414 2.199939489175645e-07 6.657589264577124 -1.1572761292645513 ITDHYK(ub)EYSQMQQQNTQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITDHYKEYSQMQQQNTQK 18 1 Q8WUB8-3;Q8WUB8-2;Q8WUB8;S5FZ81 Q8WUB8-3 PHF10 PHD finger protein 10 1 13604400.0 4432200.0 6380800.0 2791400.0 True False 5737570.271723523 6025702.8708260115 2283393.8421826935 1.0 1.0502185743192538 0.3979722659669978 22.452008487575448 -6.888314547698276 1.0323229129372393 1.036475216240765 0.3436954566193649 0.9797966070663575 0.04212210982830362 0.1205204398967971 0.22993171036926563 0.031157087889737225 0.07721693101528836 1.2932588299179395e-07 6.888314547698276 -0.6927797596214003 down ITEGDVVVGIASSGLHSNGFSLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITEGDVVVGIASSGLHSNGFSLVR 24 0 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 54030000.0 10074000.0 27707000.0 16249000.0 False True 15282994.50805134 22762469.374220915 13037378.027810302 1.0 1.4893985182177003 0.8530643664722899 23.86542391299407 -6.701272415410598 1.8264845312577604 1.3035166284352022 0.8549198199012782 0.42358779450221606 0.20653309986633397 0.3928608450580423 2.5489097839021913 0.09018360927798427 0.2315517170751853 1.9894250614363534e-07 6.701272415410598 -0.44859680853392403 ITEGDVVVGIASSGLHSNGFSLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITEGDVVVGIASSGLHSNGFSLVR 24 0 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 32935400.0 10074000.0 13161000.0 9700400.0 False True 13040991.588227717 12428578.780551214 7935026.734509213 1.0 0.9530393986121932 0.6084680509779847 23.63655023508652 -6.931741624030086 0.7323565591883626 1.0049161356527638 0.5344866188980862 0.9968695559772673 0.009766539019700092 0.09174368303141321 0.07332398188084013 0.008991775136486071 0.030884634561177366 1.1701953714097963e-07 6.931741624030086 -0.4704295167546776 ITEGVSDTNSKSWANHENK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITEGVSDTNSKSWANHENK 19 1 Q8IX04-5;Q8IX04-4;Q8IX04-3;Q8IX04-2;Q8IX04-6;Q8IX04 Q8IX04-5 UEVLD Ubiquitin-conjugating enzyme E2 variant 3 1 3075130.0 559080.0 770450.0 1745600.0 True False 541332.3114249195 1078094.7028436717 1288374.9931225094 1.0 1.9915580136087976 2.3800075590004783 19.04615497765888 -10.047210781484237 0.22610188029180756 7.181413953725885e-18 2.6493957324379376 0.9992456525232484 0.015958576302782718 1.5470416031310619 0.10395868376235824 1.1550818517137793 0.19883170549086318 8.969933400232006e-11 10.047210781484237 2.6493957324379376 ITEK(ub)LEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITEKLEK 7 1 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8Y4C5;A0A2R8YGP5 P51532 SMARCA4 Transcription activator BRG1 1 2115230.0 762950.0 876490.0 475790.0 True False 738730.5698677164 1226477.027834967 351166.3256059566 1.0 1.660249457464026 0.4753645509334202 19.494688754381286 -6.755459580422153 1.6294150625250576 1.3856669509352177 0.4719599660614264 0.6722092538098015 0.2775524084853821 0.2906174371739046 1.5195814417942308 0.13446534538110322 0.3246255015663666 1.7560643226529823e-07 6.755459580422153 -0.9137069848737913 ITENIGCVMTGMTADSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITENIGCVMTGMTADSR 17 0 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 14029600.0 2361800.0 6807300.0 4860500.0 False True 3096342.671703733 5791677.374647569 4357582.085208211 1.0 1.8704897967448653 1.4073319871958787 21.562133712450766 -10.365186754329487 5.204167184923173 0.9996824836964643 1.6389108919704087 0.7172936101895814 0.1890833839634894 0.0006969183906131064 8.501095068043215e-05 0.18316749412774289 0.06102639976124291 4.3133355586319385e-11 10.365186754329487 0.6392284082739444 ITENIGCVMTGMTADSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITENIGCVMTGMTADSR 17 0 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 11421400.0 2361800.0 4744700.0 4314900.0 False True 3235021.285245118 4535063.465375285 3295809.4881549827 1.0 1.4018651086036555 1.0187906655165202 21.625343773973658 -10.85634972176047 9.056405429132253 0.9894817933471606 1.210327887060088 0.2867050042494089 0.15638948651071938 0.03327692243129223 0.0005278288283758096 0.1517152527808302 0.050474489731495466 1.3920353953442564e-11 10.85634972176047 0.2208460937129274 ITESEEVVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITESEEVVSR 10 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 13618500.0 1277300.0 6776200.0 5565000.0 False True 1674552.669390797 5765217.373420721 4989187.183249394 1.0 3.442840275378206 2.979414905512923 20.67534432289876 -10.110815919343889 4.959329599017611 0.9999139291114101 3.211127590454435 0.9681054889011708 0.1891926150357982 0.00018005321865920446 3.228297420328584e-05 0.18319190933167312 0.06106165393386782 7.747901318239042e-11 10.110815919343889 2.2112136613430247 ITESEEVVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITESEEVVSR 10 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 15493500.0 4103300.0 1291200.0 10099000.0 False True 3973042.987532866 1806782.893519047 7453768.936494163 1.0 0.454760469289813 1.8760856501889294 21.92181297250729 -6.8027168819942005 1.4447645690100623 0.7001947983529717 1.8970538386108935 0.8399932526262548 0.23419299078416747 0.21690394451755063 0.8935369565579605 0.12750416501623943 0.29605467974072386 1.57500928361592e-07 6.8027168819942005 1.1968590402579218 ITESEEVVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITESEEVVSR 10 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 12472800.0 1277300.0 5696000.0 5499500.0 False True 1749552.3277346073 5444331.885846868 4200631.365757801 1.0 3.1118428409034293 2.400974980380811 20.73855438442165 -10.152408659227243 5.465629121555078 0.999959073395364 2.756408910642471 0.8905880804500091 0.2902105888052967 0.00014473405742436896 2.2445896086700955e-05 0.28100166686413136 0.0936650647778181 7.04030283946485e-11 10.152408659227243 1.7564498372471071 ITESEEVVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITESEEVVSR 10 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 6350730.0 4103300.0 1399600.0 847830.0 False True 3412075.7570115635 1392060.0770011507 1025107.3330769929 1.0 0.40798041313724354 0.3004351034617192 21.702218247941566 -13.999999999999995 0.23988573370579566 4.916434881742041 0.25283263186170807 0.9995247724561451 0.006705134433791163 13.619393709967262 0.15501742818275682 25.549812506644265 0.052586078203590486 1.0000000000000123e-14 13.999999999999995 -4.6636022498803325 ITFCTGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITFCTGIR 8 0 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 0 144882000.0 46636000.0 45794000.0 52452000.0 False True 61140247.62366646 38961713.703613944 47024770.195111915 1.0 0.6372514868345489 0.7691295345180994 25.865619059496808 -10.256069419840275 6.384823398889086 1.0000052797354584 0.703190511500289 0.8710312579162343 0.0538389875165218 4.046368153571903e-06 4.71516534266285e-07 0.05213030190955221 0.017376458502346426 5.545370658463451e-11 10.256069419840275 -0.2968147682351694 ITFCTGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITFCTGIR 8 0 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 0 61288000.0 31680000.0 14126000.0 15482000.0 False True 30674335.74075527 19766585.46611682 11426799.749955699 1.0 0.644401418605263 0.3725198761117278 24.870528766570963 -7.733039517600448 0.20203187649874715 1.2183815691240327 3.7969131214411233e-16 0.9999009458366245 0.002557079504672469 0.12981422983391025 0.02650854951467244 0.050838238262130006 0.08502969767302027 1.8491003568040442e-08 7.733039517600448 -1.2183815691240323 down ITFCTGIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITFCTGIR 8 0 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 0 166792000.0 41061000.0 58522000.0 67209000.0 False True 62292538.96119673 48078291.865527056 53925111.69124887 1.0 0.7718146132312248 0.8656752893767888 25.89255604016899 -10.062624932649646 5.48552648599492 1.000001307056226 0.8187449513291731 0.8325584811566334 0.038318460578567415 6.125269778395139e-07 1.0466663253442328e-07 0.03710195749279566 0.012367229972706091 8.65715248913089e-11 10.062624932649646 -0.1812563557270528 ITFCTGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITFCTGIR 8 0 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 0 126413000.0 46636000.0 38946000.0 40831000.0 False True 63878589.490512095 37225236.942800604 31187558.740841277 1.0 0.582749826502191 0.4882318001945483 25.9288291210197 -13.999999999999998 0.20864006794790463 3.399720405801155 0.4318212397492158 0.9994892928902207 0.005024746850546991 12.715160959631152 0.14478628482354539 12.500033205674903 0.05652587768059333 1.0000000000000041e-14 13.999999999999998 -2.9678991660519394 ITFCTGIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITFCTGIR 8 0 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 0 52658600.0 31680000.0 6843600.0 14135000.0 False True 26343323.661961406 6806732.168451759 17090563.14714426 1.0 0.25838547389828337 0.6487625998317851 24.65093404200524 -10.730394334276905 6.783286011234674 1.0081043648743677 0.45357403686888026 0.7231724962987662 0.15937079429854825 0.019509870445665725 0.0007754300356828534 0.15412711345685695 0.05143670268251043 1.8603971508236345e-11 10.730394334276905 -0.5545303280054874 ITFCTGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITFCTGIR 8 0 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 0 320661900.0 41061000.0 105730000.0 173870900.0 False True 53154273.93331528 99846032.55586033 142228180.26609004 1.0 1.8784196484580378 2.675761885949613 25.66368236226144 -6.972278636281385 0.19627273518260674 0.5019659622185053 4.074142127451614 0.9999951281183671 0.001510606142486469 0.07556999772884242 0.006308591349758211 0.026698946900603857 0.08546323470995609 1.0659120299677038e-07 6.972278636281385 3.5721761652331088 ITFDDYIACCVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITFDDYIACCVK 12 0 C9J0K6;P30626-3;P30626-2;P30626;B4DHQ6 C9J0K6 SRI Sorcin 0 5080100.0 1064900.0 1854400.0 2160800.0 False True 1458622.307840431 1772466.4763192472 1650463.5430729084 1.0 1.215164794060691 1.1315222139420784 20.47617493294574 -10.194052548756726 4.733281730495996 0.9999734459227919 1.173343504002234 0.8513371190202237 0.03414694034632652 9.570009051978195e-06 1.6295076734255534e-06 0.03306769446781761 0.011020877606691612 6.396574335401622e-11 10.194052548756726 0.17337005807944206 ITFHGEGDQEPGLEPGDIIIVLDQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITFHGEGDQEPGLEPGDIIIVLDQK 25 0 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 61945000.0 7427000.0 33986000.0 20532000.0 False True 11267301.98643014 27920932.76617 16473841.200504731 1.0 2.4780495632225694 1.462092808051575 23.425638760308253 -10.446932408921558 5.705625018067709 0.9993220349610923 1.970071185637073 0.5486577345221069 0.4147626084837763 0.003579155675697784 0.00034694002875466267 0.40184066399194823 0.1338640562739337 3.573284463548774e-11 10.446932408921558 0.9707491506759807 ITFHGEGDQEPGLEPGDIIIVLDQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITFHGEGDQEPGLEPGDIIIVLDQK 25 0 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 29812500.0 7427000.0 9932500.0 12453000.0 False True 9614397.908057095 9379747.643630793 10186681.778570298 1.0 0.9755938680018995 1.059523630703241 23.196765082400702 -6.828886928166443 1.3327794536624828 0.9869481017431915 1.0617326290406792 0.9036403401062041 0.010942185274470844 0.1821950800105183 0.6333188542321665 0.0064467359394705685 0.014837284117909886 1.4829041201269385e-07 6.828886928166443 0.07478452729748775 ITFLLQAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITFLLQAIR 9 0 O00410;O00410-3;H0Y8C6;E7ETV3;E7EV12;E7EQT5;C9J875;C9JQT6;C9JZD8;E7ETV8;E7ESZ1;E7EWK4;E7EX05 O00410 IPO5 Importin-5 0 16004900.0 2608600.0 8059500.0 5336800.0 False True 3419899.8617183357 6857054.015684936 4784599.130200429 1.0 2.0050452624187645 1.399046557987928 21.70552265141855 -10.69957558543847 6.605833008385319 0.9927253705512827 1.7020459102026406 0.6415099933084043 0.24739793510720498 0.02645581330819491 0.0012031729486021 0.2390921626289611 0.07984734021302557 1.9972131394153593e-11 10.69957558543847 0.7093205396513579 ITFLLQAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITFLLQAIR 9 0 O00410;O00410-3;H0Y8C6;E7ETV3;E7EV12;E7EQT5;C9J875;C9JQT6;C9JZD8;E7ETV8;E7ESZ1;E7EWK4;E7EX05 O00410 IPO5 Importin-5 0 10569100.0 6395700.0 3052800.0 1120600.0 False True 6192672.004329189 4271798.960141689 827081.2427206007 1.0 0.6898151488009293 0.13355805735269083 22.56213060487437 -7.339868833717836 0.5351502792698668 1.0073229449719932 1.3077274594818807e-27 0.9976747984216248 0.017284436450857456 0.10398183252458745 0.059325714999155274 0.017872631130465572 0.060360788757455305 4.5722626093663155e-08 7.339868833717836 -1.0073229449719932 down ITFLLQAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITFLLQAIR 9 0 O00410;O00410-3;H0Y8C6;E7ETV3;E7EV12;E7EQT5;C9J875;C9JQT6;C9JZD8;E7ETV8;E7ESZ1;E7EWK4;E7EX05 O00410 IPO5 Importin-5 0 157934000.0 36215000.0 39151000.0 82568000.0 False True 54940802.67114147 32164198.161840796 66248398.60915994 1.0 0.5854337140715921 1.2058141743159856 25.711374652186574 -6.726591856895714 1.7355064179052 0.7495772316180662 1.2052320624090544 0.5434728986372616 0.174325312719895 0.3426594744418073 2.020296686777475 0.07964972064838727 0.19842391583587765 1.8767574265849515e-07 6.726591856895714 0.45565483079098823 ITFLLQAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITFLLQAIR 9 0 O00410;O00410-3;H0Y8C6;E7ETV3;E7EV12;E7EQT5;C9J875;C9JQT6;C9JZD8;E7ETV8;E7ESZ1;E7EWK4;E7EX05 O00410 IPO5 Importin-5 0 27811400.0 2608600.0 6777800.0 18425000.0 False True 3573069.914764342 6478334.384812649 14073394.474786352 1.0 1.813100370088874 3.93874030189934 21.768732712941443 -6.9544970668051755 0.5070763037918905 0.9599194348585075 4.884712839702119 0.9995085743325447 0.027465888908445476 0.08172863461975166 0.028866144833967797 0.03179736062028191 0.1754024536367982 1.1104600352784115e-07 6.9544970668051755 3.9247934048436113 ITFLLQAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITFLLQAIR 9 0 O00410;O00410-3;H0Y8C6;E7ETV3;E7EV12;E7EQT5;C9J875;C9JQT6;C9JZD8;E7ETV8;E7ESZ1;E7EWK4;E7EX05 O00410 IPO5 Importin-5 0 22756400.0 6395700.0 6535700.0 9825000.0 False True 5318307.927550718 6500490.886865115 11879362.074332656 1.0 1.2222855418337608 2.233673235202 22.342535880308645 -6.941930212237137 0.6413655555884895 0.9889171815780591 2.522620628797987 0.9984058320020074 0.02143645613814685 0.08689719635872159 0.05068376566117152 0.021185504051208195 0.08633500501317778 1.1430620012515782e-07 6.941930212237137 1.5337034472199278 up ITFLLQAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITFLLQAIR 9 0 O00410;O00410-3;H0Y8C6;E7ETV3;E7EV12;E7EQT5;C9J875;C9JQT6;C9JZD8;E7ETV8;E7ESZ1;E7EWK4;E7EX05 O00410 IPO5 Importin-5 0 121345000.0 36215000.0 44233000.0 40897000.0 False True 46881031.404374294 41771394.66606807 33454165.638656486 1.0 0.8910084401891067 0.713597048454335 25.482500974279024 -6.963863360337657 0.3770519482911343 1.0125976786322763 0.5857633396018136 0.9998877603291623 0.0012504389776067113 0.07834882828041305 0.016233151181681404 0.0023163377975236768 0.01501266395590407 1.0867674934584362e-07 6.963863360337657 -0.42683433903046275 ITFPSLQALVQHYSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITFPSLQALVQHYSK 15 0 E9PJX5;P51451 E9PJX5 BLK Non-specific protein-tyrosine kinase;Tyrosine-protein kinase Blk 0 2721500.0 0.0 0.0 2721500.0 False True 0.0 0.0 2008657.5067500602 0.0 ITGEAFVQFASQELAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITGEAFVQFASQELAEK 17 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 20897500.0 8803100.0 3852500.0 8241900.0 False True 8523650.409073317 5390823.34052209 6083099.138299949 1.0 0.6324547678285383 0.713672997642485 23.02303999263731 -9.97931995990214 5.628065030529324 1.0000005888562102 0.6730638827352403 0.9557623125239227 0.033157203477012426 2.4496563607875416e-07 4.445573468617255e-08 0.03210438210143977 0.010701441405965958 1.0487694788795275e-10 9.97931995990214 -0.3269367061209699 ITGEAFVQFASQELAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITGEAFVQFASQELAEK 17 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 31088300.0 8131300.0 11901000.0 11056000.0 False True 10526128.141885644 11238698.888180206 9043921.444139805 1.0 1.0676954276719373 0.8591878535234783 23.32747152719283 -6.819274407698757 1.3749090149417764 1.0365143958544827 0.8547024151262543 0.8827348272341192 0.02974088034025815 0.19442092428136132 0.7223535842192199 0.01699884134749073 0.03918932468713344 1.516092126382455e-07 6.819274407698757 -0.18181198072822835 ITGEAFVQFASQELAEK(ub)ALGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITGEAFVQFASQELAEKALGK 21 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 117555000.0 24594000.0 35860000.0 57101000.0 True False 37310896.06224081 29460502.824541215 45814962.32174262 1.0 0.789595156744458 1.2279244713210749 25.153093672691817 -6.776171542132659 1.5507339049253137 0.8802716003666676 1.2309922066112444 0.7536328383502711 0.08884477723239086 0.25656603235415804 1.2183536451515724 0.04513690061972292 0.106852369743961 1.6742814203839743e-07 6.776171542132659 0.3507206062445768 ITGEAFVQFASQELAEK(ub)ALGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITGEAFVQFASQELAEKALGK 21 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 122435000.0 24594000.0 25994000.0 71847000.0 True False 31837417.820217572 24547411.049437582 58771583.212474115 1.0 0.7710239312765294 1.845990888593756 24.924219994784266 -6.851017884019269 1.230189791773451 0.8776978270297825 1.8898099330666203 0.9417712389150972 0.11156152746907522 0.15634060371207542 0.4547907718939775 0.07094361750728215 0.16427592234087066 1.4092307658422648e-07 6.851017884019269 1.0121121060368377 ITGHFYACQVAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITGHFYACQVAQR 13 0 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 0 69237720.0 21044900.0 15370320.0 32822500.0 False True 27590067.69910147 13077128.169038102 29426342.55565203 1.0 0.4739795607483771 1.066555648814532 24.717645660918603 -6.672496658767841 1.9284284387723307 0.664962912339487 1.0641915556884163 0.29013834560967355 0.22331511551146785 0.45544380243451993 3.267648342604971 0.09314580183024423 0.24806341558697823 2.1257066992178114e-07 6.672496658767841 0.39922864334892927 ITGHFYACQVAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITGHFYACQVAQR 13 0 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 0 31836460.0 14568660.0 3485800.0 13782000.0 False True 14106185.86278131 4877698.118206853 10172080.748862505 1.0 0.34578433643615125 0.7211078067318816 23.749824618078257 -10.728968556136252 7.002729251626037 1.0059012230558084 0.533446071584256 0.6732349177297314 0.15322516511919637 0.014167182787645383 0.0005483216113421962 0.1488873832423113 0.049453209393877394 1.8665148256699062e-11 10.728968556136252 -0.47245515147155237 ITGHFYACQVAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITGHFYACQVAQR 13 0 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 0 46821000.0 10472000.0 18752000.0 17597000.0 False True 15886789.605748791 15405559.089955263 14118945.236960907 1.0 0.9697087625797354 0.8887223653954495 23.921324279281123 -6.954007853506457 0.5129648192227474 1.0014548910545598 0.8534052573533912 0.9994793951928145 0.0010717807711328386 0.08191527239722564 0.02960303512764393 0.0012282569506249824 0.006685410410785723 1.111711623610648e-07 6.954007853506457 -0.14804963370116853 ITGHFYACQVAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITGHFYACQVAQR 13 0 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 0 51582100.0 21044900.0 12075000.0 18462200.0 False True 28825768.247038253 11541486.57331476 14101808.600944402 1.0 0.40038782225693526 0.48920842213436283 24.780855722441494 -10.750606212617619 7.009910789279837 1.0099134021754617 0.44479812219564907 0.9811665637808439 0.03626085805793461 0.005575391943516893 0.0001983572722536185 0.034843675293039666 0.011703141614797647 1.7757989194187616e-11 10.750606212617619 -0.5651152799798126 ITGHFYACQVAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITGHFYACQVAQR 13 0 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 0 25812660.0 14568660.0 3704700.0 7539300.0 False True 12114486.291069156 3684742.045774629 9115732.772215404 1.0 0.30415999137256317 0.7524654824972278 23.530229893512534 -9.923096835894523 6.424384182427474 1.0000000569133942 0.5283127369357056 0.5961297416932302 0.18301995035729193 1.4928628710869422e-07 2.5072787458281932e-08 0.17720832606408557 0.0590694349797791 1.1937219071678375e-10 9.923096835894523 -0.47168731997768865 ITGHFYACQVAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITGHFYACQVAQR 13 0 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 0 54961800.0 10472000.0 29178800.0 15311000.0 False True 13556210.433980582 27554974.12977341 12524555.10412668 1.0 2.03264579463173 0.9238979554885111 23.692450601373572 -6.662116090849399 1.9650759470206847 1.663520361554035 0.9284672756544782 0.24480479227426888 0.4394516266875899 0.47941925954588027 3.5609263440397125 0.1805236019474117 0.4873705328311641 2.1771277285988202e-07 6.662116090849399 -0.7350530858995569 ITGK(ub)QFYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITGKQFYK 8 1 Q8N370-4;Q8N370;Q8N370-3;Q8N370-2 Q8N370-4 SLC43A2 Large neutral amino acids transporter small subunit 4 1 5630450.0 2099100.0 2589000.0 942350.0 True False 2751940.4277133187 2202731.291842955 844844.6616594909 1.0 0.8004284066836722 0.3069996185787718 21.39201780914151 -6.955698725347324 0.4923240349745508 1.0105743307001667 0.07584740756930834 0.999575924875525 0.005998170058556726 0.08127492928921083 0.02709260864108912 0.007140185179537326 0.04069690431925733 1.107391726877123e-07 6.955698725347324 -0.9347269231308584 down ITGK(ub)QFYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITGKQFYK 8 1 Q8N370-4;Q8N370;Q8N370-3;Q8N370-2 Q8N370-4 SLC43A2 Large neutral amino acids transporter small subunit 4 1 4602400.0 2099100.0 1403500.0 1099800.0 True False 2875193.996044558 1341488.7292461516 840049.8910919952 1.0 0.4665732924775355 0.292171551640572 21.4552278706644 -13.999999999999945 0.15630729627504233 3.6075981505069805 0.11354362130205324 0.9995465716136949 0.006411696845860954 11.987074043732212 0.1248033240570634 9.480405980583441 0.16208204167131812 1.0000000000001268e-14 13.999999999999945 -3.494054529204927 ITGK(ub)QFYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITGKQFYK 8 1 Q8N370-4;Q8N370;Q8N370-3;Q8N370-2 Q8N370-4 SLC43A2 Large neutral amino acids transporter small subunit 4 1 5065400.0 1308300.0 2145600.0 1611500.0 True False 1087909.417517174 2134041.226931744 1948457.199265864 1.0 1.9615982659678146 1.7910105086806136 20.053127007953666 -10.201221524493793 4.548894537584547 0.9997963343664948 1.876304387324159 0.972363956601447 0.06964216032129897 0.00014393759680502984 2.527547493157294e-05 0.06744609378161778 0.022476910588303103 6.29185166853473e-11 10.201221524493793 0.8765080529576641 ITGK(ub)QFYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITGKQFYK 8 1 Q8N370-4;Q8N370;Q8N370-3;Q8N370-2 Q8N370-4 SLC43A2 Large neutral amino acids transporter small subunit 4 1 6733900.0 3148700.0 1766300.0 1818900.0 True False 4076054.220156104 1668003.8522975128 1487878.8634900413 1.0 0.4092202316763176 0.3650292128432626 21.958741811855884 -13.999999999999998 0.36786034435522064 9.119263473305569 0.3602932139320261 0.9997872159362895 0.004222601156726742 22.571858670283905 0.19667647208653813 144.38403910064244 0.012433809535309825 1.0000000000000041e-14 13.999999999999998 -8.758970259373543 ITGMLLEIDNSELLHMLESPESLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITGMLLEIDNSELLHMLESPESLR 24 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAS6;H0YB75;H0YAS7;H0YER0;H0Y6X6;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 47615000.0 14159000.0 20550000.0 12906000.0 False True 21480238.16155437 16882691.942117166 10355123.443099242 1.0 0.7859639085535859 0.4820767519064563 24.35650665346543 -6.966154697880908 0.33765415274195604 1.033869605896783 0.22410792324241863 0.9999350008530893 0.0017132026745831784 0.07757135452957961 0.01349060134408512 0.004321266587704596 0.026348466340947375 1.0810488076791302e-07 6.966154697880908 -0.8097616826543643 down ITGNMGLAMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITGNMGLAMK 10 0 P22307-7;P22307-8;P22307;P22307-6;P22307-2;P22307-4 P22307-7 SCP2 Non-specific lipid-transfer protein 0 34433000.0 10902000.0 13245000.0 10286000.0 False True 14292627.575118182 11268897.62860562 9221703.390279116 1.0 0.7884412834084805 0.6452070021283588 23.76876783194823 -7.928673273584665 0.08017940435903466 1.5671017453099734 8.966725329533621e-05 0.9999964954328184 0.00027276410193098236 0.11887596923871362 0.012169159541120522 0.10797147735296175 0.1227327438715147 1.1784922379319093e-08 7.928673273584665 -1.567012078056678 ITGNMGLAMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITGNMGLAMK 10 0 P22307-7;P22307-8;P22307;P22307-6;P22307-2;P22307-4 P22307-7 SCP2 Non-specific lipid-transfer protein 0 7852800.0 5198500.0 2654300.0 0.0 False True 5033476.463015033 3714175.8319916395 0.0 1.0 0.7378947451691992 0.0 22.263123737453867 -7.356093430411351 0.7847064740906272 0.9895440069096118 4.4753857848869626e-23 0.9877725132765247 0.046815515412199055 0.1094457304311989 0.1380086046662911 0.04024369919191449 0.07170348992853284 4.4046009648413974e-08 7.356093430411351 -0.9895440069096118 down ITGNMGLAMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITGNMGLAMK 10 0 P22307-7;P22307-8;P22307;P22307-6;P22307-2;P22307-4 P22307-7 SCP2 Non-specific lipid-transfer protein 0 17423700.0 10902000.0 6521700.0 0.0 False True 14932764.015472224 6233549.729622104 0.0 1.0 0.4174411196188034 0.0 23.831977893471123 -8.212597925549865 0.5460748663262985 1.0274492013646381 7.862252393723951e-20 0.9913191516547749 0.03820937785148821 0.13103706229383735 0.17354831977493743 0.0545320537779758 0.07278320329627473 6.129175747413957e-09 8.212597925549865 -1.0274492013646381 ITGNMGLAMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITGNMGLAMK 10 0 P22307-7;P22307-8;P22307;P22307-6;P22307-2;P22307-4 P22307-7 SCP2 Non-specific lipid-transfer protein 0 11011300.0 5198500.0 3169800.0 2643000.0 False True 4322783.082598054 3152723.658243959 3195639.080148728 1.0 0.729327287074772 0.7392550167537215 22.043529012888143 -10.162487385506795 5.106873383138085 1.0000140389664964 0.7342911519139648 0.9989540870836158 0.004052978670599815 6.478747223784124e-07 1.0624909276415013e-07 0.003924486978890278 0.0013080932410063871 6.87879892139472e-11 10.162487385506795 -0.26572288705253166 ITGYIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITGYIIK 7 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1;H0Y4K8 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 9084400.0 1752500.0 2448900.0 4883000.0 False True 2297544.471234141 2083533.6657374355 4377754.00104345 1.0 0.9068523773201447 1.9054055561727217 21.131661355890945 -6.884070437564297 1.0568826026291365 0.9384744424902002 1.9819233030886523 0.9768213489957319 0.0685676069400663 0.12408359165552471 0.2510397152158582 0.049780686608018404 0.12172431151247785 1.3059590594321945e-07 6.884070437564297 1.0434488605984522 ITGYIIKYEKPGSPPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITGYIIKYEKPGSPPR 16 2 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1;H0Y4K8 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 5608010.0 2456400.0 751110.0 2400500.0 False True 3220364.187811435 639047.3158038482 2152119.287221956 1.0 0.1984394554574108 0.6682844429109553 21.618792419850163 -9.714624495785188 14.302448004846312 1.0000065289982005 0.43336146058902525 0.6597808804502501 0.1918134129483789 0.0 0.0 0.18572253846589562 0.06190751282196519 1.929192230544639e-10 9.714624495785188 -0.5666450684091753 ITHLSTLQVGSLNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITHLSTLQVGSLNVK 15 0 H3BQW8;H3BPK3;H3BPQ4;Q16775-2;Q16775 H3BQW8 HAGH Hydroxyacylglutathione hydrolase, mitochondrial 0 33363800.0 13123000.0 8694800.0 11546000.0 False True 17204380.083312757 7397569.732064948 10351330.677052569 1.0 0.42998176605271343 0.6016683325365937 24.036272573325483 -10.921051877909468 11.558594248811074 1.0592206277993772 0.5158250492946539 0.9138230042897588 0.07009074726265448 0.03447638680989895 0.00023548206053217502 0.021873954263968265 0.022621691405957812 1.199356027555616e-11 10.921051877909468 -0.5433955785047233 ITHLSTLQVGSLNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITHLSTLQVGSLNVK 15 0 H3BQW8;H3BPK3;H3BPQ4;Q16775-2;Q16775 H3BQW8 HAGH Hydroxyacylglutathione hydrolase, mitochondrial 0 21277000.0 6442700.0 3394300.0 11440000.0 False True 6238180.015055682 4749661.691040668 8443520.807356484 1.0 0.7613858015603086 1.3535231088199235 22.572693754463444 -6.797326012352518 1.466777334933357 0.8678946469197986 1.3611695396342551 0.824227174695789 0.10198387493060253 0.22460341557400573 0.9542445130079577 0.05470524250204634 0.12743864910296704 1.5946816162815117e-07 6.797326012352518 0.49327489271445657 ITHLSTLQVGSLNVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITHLSTLQVGSLNVK 15 0 H3BQW8;H3BPK3;H3BPQ4;Q16775-2;Q16775 H3BQW8 HAGH Hydroxyacylglutathione hydrolase, mitochondrial 0 17233000.0 2592900.0 10795000.0 3845100.0 False True 3933618.8663814105 8868547.908280026 3085114.2996328045 1.0 2.2545519048820113 0.784294158745187 21.907425749050706 -6.680775584777121 1.899471619902181 1.7932525606196026 0.7899129407032129 0.3274531953474987 0.5316254686234635 0.43684746500295013 3.048077986675553 0.22454102074820104 0.5915504060738611 2.0855682911431876e-07 6.680775584777121 -1.0033396199163898 ITHLSTLQVGSLNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITHLSTLQVGSLNVK 15 0 H3BQW8;H3BPK3;H3BPQ4;Q16775-2;Q16775 H3BQW8 HAGH Hydroxyacylglutathione hydrolase, mitochondrial 0 34834600.0 13123000.0 8225600.0 13486000.0 False True 17974927.735740397 7862165.793578293 10300884.552888386 1.0 0.4373962393153647 0.5730695947337051 24.099482634848375 -10.112395777385874 7.744749881151757 1.0000000660888406 0.5052329170247208 0.946614658061858 0.05538841541103356 6.318139422767155e-08 7.326148967510307e-09 0.05362960900800965 0.017876534204979276 7.719767534484155e-11 10.112395777385874 -0.4947671490641198 ITHLSTLQVGSLNVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITHLSTLQVGSLNVK 15 0 H3BQW8;H3BPK3;H3BPQ4;Q16775-2;Q16775 H3BQW8 HAGH Hydroxyacylglutathione hydrolase, mitochondrial 0 12250900.0 6442700.0 2752300.0 3055900.0 False True 5357390.510003749 2737472.813611223 3694874.5611148337 1.0 0.5109713037531227 0.6896780352702435 22.35309902989772 -10.217115279045114 6.41957224525636 1.0000037663584709 0.6003246695116831 0.8696077431190702 0.07295671763625006 3.932797025186648e-06 4.797038843075841e-07 0.0706407036629535 0.023546679366595987 6.065752989848776e-11 10.217115279045114 -0.3996790968467878 ITHLSTLQVGSLNVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITHLSTLQVGSLNVK 15 0 H3BQW8;H3BPK3;H3BPQ4;Q16775-2;Q16775 H3BQW8 HAGH Hydroxyacylglutathione hydrolase, mitochondrial 0 15846100.0 2592900.0 6540300.0 6712900.0 False True 3356560.1637001843 6176326.555614247 5491221.0801706 1.0 1.840076225180968 1.6359668268592036 21.678552071143155 -10.144096298835256 4.736770003315932 0.9999348596553947 1.7380215260262115 0.9457469496035513 0.08332731295350286 5.7327162349211015e-05 1.0358336075963894e-05 0.08068840213059925 0.02689377460977836 7.176351478925281e-11 10.144096298835256 0.7380866663708168 ITIAAYLPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITIAAYLPLK 10 0 Q8TEM1;Q8TEM1-2 Q8TEM1 NUP210 Nuclear pore membrane glycoprotein 210 0 4552230.0 634430.0 1912100.0 2005700.0 False True 868995.9158260901 1827617.0995308603 1531994.968688138 1.0 2.103136581250189 1.762948410674386 19.728989871003193 -10.154533262642287 4.8619024068512 0.9999276699919433 1.9330424959659802 0.9093385931009141 0.13888123908635705 0.00010889565564685664 1.8936149416496147e-05 0.13448151517067405 0.04482372717169243 7.005945222310071e-11 10.154533262642287 0.9331148259740369 ITIADCGQLE ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITIADCGQLE 10 0 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 8512900.0 1636100.0 3396000.0 3480800.0 False True 2144942.94401494 2889330.0375043233 3120640.206191287 1.0 1.3470428411937276 1.4548826181595398 21.032507841533153 -12.433226523283766 0.18596357344115771 6.508619111188205e-09 1.5420074380239055 0.9994516649510701 0.004544566909637765 6.457320404575344 0.12402968710636725 2.4968568687399717 0.07619838744683403 3.6878519404557236e-13 12.433226523283766 1.5420074315152863 ITIADCGQLE ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITIADCGQLE 10 0 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 5680000.0 1636100.0 2122800.0 1921100.0 False True 2241010.3839400224 2029007.676839137 1467375.7462964477 1.0 0.9053986056378044 0.6547831089102709 21.095717903056045 -6.954208040654247 0.510561692394985 1.0045911478878637 0.5445851613444216 0.9994914734313693 0.0032845399401379787 0.0818387371348801 0.029300266895081646 0.0037794893315746384 0.02068467863382323 1.1111993005115148e-07 6.954208040654247 -0.46000598654344216 ITIENRSK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITIENRSK 8 1 Q02880;Q02880-2;E9PCY5 Q02880 TOP2B DNA topoisomerase 2-beta;DNA topoisomerase 2 1 17670000.0 5636900.0 5580800.0 6452300.0 True False 8551589.412590278 4584862.637010584 5177000.076856451 1.0 0.5361415774078689 0.6053845463200667 23.02776115593731 -10.61253955924648 6.509016963589632 1.0012903588555788 0.5707630618640102 0.9808563876624923 0.02826832368504713 0.0005307239151417124 3.159222456377013e-05 0.0274426813086073 0.009123562238115696 2.4403967657605152e-11 10.61253955924648 -0.43052729699156866 ITIENRSK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITIENRSK 8 1 Q02880;Q02880-2;E9PCY5 Q02880 TOP2B DNA topoisomerase 2-beta;DNA topoisomerase 2 1 9540500.0 5636900.0 0.0 3903600.0 True False 7297078.169910731 0.0 3193184.854318396 1.0 0.0 0.43759773158048276 22.79888747802976 -10.636593039698045 6.134416446257377 1.0046075836784747 0.21879886579024554 0.809497325985743 0.1786485258285965 0.01127614017057916 0.0006680050811334314 0.17325979679730857 0.057658563779888275 2.30890976398641e-11 10.636593039698045 -0.7858087178882291 ITIK(ub)NDPSLPEPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITIKNDPSLPEPK 13 1 O43776;K7EIU7;O43776-2;K7EPK2;K7EJ19;K7EMQ6 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 1 5856700.0 1218000.0 2001400.0 2637300.0 True False 1576725.010369399 1890020.3306280037 2157338.460983169 1.0 1.19870003849638 1.3682401476448591 20.588499637334664 -6.972968919645002 0.17315843776297932 0.8564288867457311 1.7150653200536834 0.9999972413440579 0.0002498859296842849 0.0753506145124813 0.005419662245332825 0.006941658943210155 0.01943940697199592 1.0642191765170248e-07 6.972968919645002 0.8586364333079523 ITINK(ub)DTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITINKDTK 8 1 P52435;A0A0B4J2F8;F6S314;E2QRJ6;A6NFM0;Q9H1A7;Q9GZM3;D6RAG0;E7EP90;A0A0B4J1Z8;Q9GZM3-2;E7EWC6 P52435;E7EWC6 POLR2J;POLR2J3;POLR2J2 DNA-directed RNA polymerase II subunit RPB11-a;DNA-directed RNA polymerase II subunit RPB11-b2;DNA-directed RNA polymerase II subunit RPB11-b1 1 2617150.0 580710.0 1107100.0 929340.0 True False 761316.4336036396 941924.9954420011 833180.8116587606 1.0 1.2372319233718143 1.0943948861250188 19.538136694662583 -10.241975930215872 4.478083861322187 0.9999331465296334 1.1658134047502353 0.6424467145396456 0.058312976277107055 3.893659692019682e-05 6.591038507666786e-06 0.05648403342041297 0.018820432164885006 5.7282777778311824e-11 10.241975930215872 0.16588025822060193 ITINK(ub)DTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITINKDTK 8 1 P52435;A0A0B4J2F8;F6S314;E2QRJ6;A6NFM0;Q9H1A7;Q9GZM3;D6RAG0;E7EP90;A0A0B4J1Z8;Q9GZM3-2;E7EWC6 P52435;E7EWC6 POLR2J;POLR2J3;POLR2J2 DNA-directed RNA polymerase II subunit RPB11-a;DNA-directed RNA polymerase II subunit RPB11-b2;DNA-directed RNA polymerase II subunit RPB11-b1 1 3723320.0 613820.0 1040800.0 2068700.0 True False 594334.620088081 1456396.8677002972 1526845.410330276 1.0 2.45046614899273 2.56899961524031 19.180915895053335 -10.600603118782663 0.48678314095725445 1.1602035271668766e-20 2.5659952286734744 0.9996179621740919 0.013942755280844016 2.07399053297768 0.2323254329788138 2.5536156471053086 0.024683663733428403 2.5084005147052318e-11 10.600603118782663 2.5659952286734744 ITINK(ub)DTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITINKDTK 8 1 P52435;A0A0B4J2F8;F6S314;E2QRJ6;A6NFM0;Q9H1A7;Q9GZM3;D6RAG0;E7EP90;A0A0B4J1Z8;Q9GZM3-2;E7EWC6 P52435;E7EWC6 POLR2J;POLR2J3;POLR2J2 DNA-directed RNA polymerase II subunit RPB11-a;DNA-directed RNA polymerase II subunit RPB11-b2;DNA-directed RNA polymerase II subunit RPB11-b1 1 3258020.0 613820.0 1433000.0 1211200.0 True False 510418.5268366526 1425280.1445717711 1464456.3200439431 1.0 2.7923754127911944 2.8691284564453277 18.96132117048761 -10.554115863507585 0.6040515419738729 1.3570104744085557e-20 2.8598740087615595 0.9998421778244128 0.010849088684608424 1.9905221927589662 0.29538037673388484 3.0779060104297966 0.01326174845965965 2.7917989301641212e-11 10.554115863507585 2.8598740087615595 ITITGYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITITGYR 7 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 11858000.0 1657200.0 2228900.0 7971900.0 False True 2172605.2483476307 1896356.8081841532 7147044.2598644905 1.0 0.8728492254294343 3.289619347693354 21.050994637084806 -6.894488164050379 0.9954808145671145 0.8837675238955752 3.5167011156576686 0.9836180521494998 0.14213772062440033 0.11557610846732534 0.20119292202179803 0.10810308943834972 0.2742349739451604 1.2750048475358087e-07 6.894488164050379 2.6329335917620935 up ITITGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITITGYR 7 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 6258500.0 1657200.0 1832400.0 2768900.0 False True 2269911.6241460824 1751438.509063516 2114942.847285529 1.0 0.7715888541354069 0.9317291584341523 21.114204698607697 -10.300339984834276 5.199612814029952 1.0000341427703645 0.8516590063970075 0.5336014458824674 0.06537700546439187 2.588202547289001e-05 3.482666883121675e-06 0.0633155723597371 0.02110033778236554 5.007950357378279e-11 10.300339984834276 -0.14837513637335698 ITITNDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITITNDK 7 0 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931;P17066 A8K7Q2;E9PM13;P11142;P0DMV9;Q53FA3;P17066 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA1L;HSPA6 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6 0 57095100.0 2267100.0 35255000.0 19573000.0 False True 2972190.0546276285 29995091.422913678 17547773.71747358 1.0 10.09191568224651 5.903987764898183 21.50309494028215 -10.434097540784613 9.551439196600924 0.9999725551716429 7.997951723572321 0.7882660124021641 1.7097144128433415 0.0010022638921476695 5.9390374925209117e-05 1.6554297652964425 0.5518079539760877 3.6804630264767385e-11 10.434097540784613 6.997979168400678 ITITNDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITITNDK 7 0 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931;P17066 A8K7Q2;E9PM13;P11142;P0DMV9;Q53FA3;P17066 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA1L;HSPA6 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6 0 31889800.0 10242000.0 6338800.0 15309000.0 False True 9916873.316187365 8869915.896405322 11299113.639844455 1.0 0.894426661872035 1.1393826743153865 23.241453895352887 -6.789588656959471 1.497983341124193 0.9409618856892344 1.1419575481118502 0.7999578422938572 0.044869142820756464 0.23598259389016035 1.0461231074344604 0.023576952295920012 0.05521582633506641 1.6233469262998173e-07 6.789588656959471 0.2009956624226158 ITITNDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITITNDK 7 0 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931;P17066 A8K7Q2;E9PM13;P11142;P0DMV9;Q53FA3;P17066 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA1L;HSPA6 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6 0 43152100.0 2267100.0 19740000.0 21145000.0 False True 3105308.136073845 18867821.528549343 16150986.494944753 1.0 6.0759901116945585 5.2010898072630685 21.56630500180504 -9.89004916431117 6.847111799997859 0.9999998847140148 5.638539959478874 0.9740115778013513 0.35717655361068595 6.356968671507942e-07 1.0235762052580002e-07 0.3458347109461917 0.11527823698246348 1.2881037236441302e-10 9.89004916431117 4.638540074764859 ITITNDK(ub)GR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITITNDKGR 9 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931;P17066 A8K7Q2;E9PM13;P11142;P0DMV9;Q53FA3;P17066 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA1L;HSPA6 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6 1 1524440000.0 535230000.0 595560000.0 393650000.0 True False 701691713.1746932 506704769.47469777 352918874.1574348 1.0 0.722118788010467 0.502954313883385 29.38626208369884 -7.158965524174511 0.15239336160107753 1.2597649731408493 4.3372667698101246e-13 0.9999972237448514 0.00033884032946601624 0.08484783908201401 0.006155080168213234 0.01536331952635201 0.03352191068620344 6.934808547841385e-08 7.158965524174511 -1.2597649731404157 ITITNDK(ub)GR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITITNDKGR 9 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931;P17066 A8K7Q2;E9PM13;P11142;P0DMV9;Q53FA3;P17066 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA1L;HSPA6 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6 1 1821630000.0 589850000.0 681640000.0 550140000.0 True False 571125534.6175665 953822406.7056409 406041830.1537678 1.0 1.6700748765231335 0.7109502299273994 29.089232647007126 -6.718924703966673 1.7637258924806856 1.4081447753921827 0.7125885180390433 0.5072152918572057 0.2820077032392339 0.35739895083301304 2.1722925979583496 0.1270014199835103 0.31915978533894424 1.910184409081383e-07 6.718924703966673 -0.6955562573531394 ITITNDK(ub)GR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITITNDKGR 9 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931;P17066 A8K7Q2;E9PM13;P11142;P0DMV9;Q53FA3;P17066 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA1L;HSPA6 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6 1 4653200000.0 1566400000.0 1513800000.0 1573000000.0 True False 2376343319.179231 1243650562.626617 1262095860.5296085 1.0 0.5233463332462261 0.5311083841898424 31.146096136714302 -10.71489702158407 10.455180320147099 1.0004941391768214 0.527227358718221 0.9997978735175537 0.0031688440282247534 3.6532217981675606e-05 9.96199924157876e-07 0.0030709921936146987 0.001022740012336939 1.927982015469233e-11 10.71489702158407 -0.4732667804586004 ITITNDK(ub)GR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITITNDKGR 9 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931;P17066 A8K7Q2;E9PM13;P11142;P0DMV9;Q53FA3;P17066 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA1L;HSPA6 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6 1 1317200000.0 535230000.0 394850000.0 387120000.0 True False 733118995.0468905 377404221.4056589 295690228.9866641 1.0 0.514792583407991 0.40333183423756697 29.44947214522173 -13.999999999999998 0.20666071921528553 3.7683303640508914 0.3355162842765805 0.9994884101943527 0.005858798403705943 12.670574337788931 0.14411105465771082 14.220040053219645 0.06760299610456054 1.0000000000000041e-14 13.999999999999998 -3.4328140797743107 ITITNDK(ub)GR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITITNDKGR 9 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931;P17066 A8K7Q2;E9PM13;P11142;P0DMV9;Q53FA3;P17066 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA1L;HSPA6 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6 1 1803510000.0 589850000.0 857710000.0 355950000.0 True False 490486409.78560424 853089345.9878938 430377499.273151 1.0 1.7392721367362378 0.8774504057335097 28.869637922441402 -6.679649704445485 1.9032594548637594 1.4678945402672001 0.8807489781193831 0.3224860723974121 0.3133451727263375 0.43928943533382975 3.0763181744918158 0.13212447297674307 0.3486096144605517 2.090982006256211e-07 6.679649704445485 -0.587145562147817 ITITNDK(ub)GR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITITNDKGR 9 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931;P17066 A8K7Q2;E9PM13;P11142;P0DMV9;Q53FA3;P17066 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA1L;HSPA6 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6 1 4375500000.0 1566400000.0 1680700000.0 1128400000.0 True False 2027735678.360121 1587167567.5459623 923042778.3617364 1.0 0.7827290235527854 0.4552086291188719 30.91722245880675 -6.965175146784455 0.35503622612208235 1.0298720791919205 0.19692786536451226 0.9999167068098352 0.0020436281672378746 0.07790160823443108 0.014650836972741211 0.004441428031188543 0.028059758747209295 1.0834898648643881e-07 6.965175146784455 -0.8329442138274082 down ITITNDQNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITITNDQNR 9 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 57893800.0 3566800.0 31844000.0 22483000.0 False True 4676109.340940332 27092999.3269398 20156674.83216463 1.0 5.793919121979211 4.310565335948981 22.156877233964508 -10.295918874412667 7.487422934751711 0.9999783258530134 5.052242228964096 0.9086790403180464 0.6055766472999404 0.0002191040534346637 2.0603425078518807e-05 0.5863501302922273 0.19544902248706603 5.0591915815126e-11 10.295918874412667 4.052263903111083 ITITNDQNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITITNDQNR 9 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 43409300.0 14920000.0 5706300.0 22783000.0 False True 14446372.766795099 7984855.3479613885 16815448.824650615 1.0 0.552723889716769 1.1639910651690246 23.784203966746592 -6.710584145618619 1.7934341318686888 0.7251850964797515 1.1625608653317465 0.4677573488974355 0.1884625217230489 0.37389058287655486 2.344661946910041 0.08362005122766715 0.21225914375501959 1.9472237340271927e-07 6.710584145618619 0.43737576885199503 ITITNDQNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITITNDQNR 9 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 187614100.0 3975400.0 180420000.0 3218700.0 False True 6030972.440669773 148222641.37210596 2582522.5341936713 1.0 24.576905769386173 0.42820997104521136 22.52395921195042 -12.170601251125754 9.134356131627426e-11 8.855417537393816 13.84916509374303 0.0 11.56713615044908 1370636864.158279 0.9547304203214233 674664567.5226576 674664553.773636 6.751476321766683e-13 12.170601251125754 4.993747556349215 ITITNDQNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITITNDQNR 9 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 69253800.0 3566800.0 29441000.0 36246000.0 False True 4885542.349145689 28140199.27163228 27685441.30980221 1.0 5.759892609784258 5.666810219062666 22.2200872954874 -10.11631699395844 4.435340133078903 0.9994346695409084 5.713351414645499 0.9997075782357676 0.038000727693467184 2177836.4825657136 14.571291575164908 12620.095036143708 0.013525760321523203 7.650379975794781e-11 10.11631699395844 4.713916745104591 ITITNDQNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITITNDQNR 9 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 18126000.0 14920000.0 2033300.0 1172700.0 False True 12406641.06807021 2022346.2093215475 1417906.1480478274 1.0 0.16300513557422622 0.11428606181708258 23.564609242180868 -13.453287323207892 0.4100005940414695 9.999496760041108 0.11201901534839132 0.9998412130391875 0.005122749896762071 17.778109026150954 0.21160863113870784 140.43408650363656 0.012136425265464346 3.521378244583943e-14 13.453287323207892 -9.887477744692717 ITK(ub)EAGSVSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITKEAGSVSLR 11 1 Q13813;A0A0D9SGF6;Q13813-2 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 1 5878400.0 1062100.0 1873600.0 2942700.0 True False 1028384.2168641461 2621738.250694924 2171918.590892305 1.0 2.5493762036618914 2.1119719218514854 19.971947943003403 -10.566965151100673 5.48945099466121 0.9944159652879846 2.3306740627566898 0.9250376249338939 0.1785695502906764 0.012193648436374313 0.0009618942828672017 0.17275894072305845 0.05763307453462747 2.710409113320416e-11 10.566965151100673 1.336258097468705 ITK(ub)EAGSVSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITKEAGSVSLR 11 1 Q13813;A0A0D9SGF6;Q13813-2 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 1 2285110.0 646380.0 926760.0 711970.0 True False 885364.153762697 885812.6788145091 543817.349482422 1.0 1.0005065995160363 0.6142301415426185 19.755911437848095 -6.906601230497052 0.9185780966964675 1.0132830444657817 0.5677774022829959 0.9895742991003913 0.01858061108503721 0.10670840952121885 0.15127970122907358 0.014961047607616056 0.040388106336149816 1.2399345728093733e-07 6.906601230497052 -0.44550564218278577 ITK(ub)EAGSVSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITKEAGSVSLR 11 1 Q13813;A0A0D9SGF6;Q13813-2 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 1 5548580.0 1062100.0 3866500.0 619980.0 True False 883183.2090078657 3845670.39705984 749614.9515363635 1.0 4.354329155985562 0.8487649492096349 19.75235321843768 -6.656176515411479 1.9859851285512844 3.16595391302062 0.8633546428453648 0.21947111150037102 1.4295257992379664 0.4937138398546773 3.739036595039337 0.582298351579775 1.5845704626660162 2.207107490050675e-07 6.656176515411479 -2.3025992701752553 ITKFENAFLSHVVSQHQALLGTIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITKFENAFLSHVVSQHQALLGTIR 24 1 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 15527400.0 4439600.0 5662400.0 5425400.0 False True 3691724.107627648 5631895.527301598 6559826.055784673 1.0 1.5255461575975489 1.776900403318629 21.81586330989456 -10.644387907633543 0.14871687854360957 1.7921834492556317e-18 2.131528766311422 0.9996812541951038 0.0057789049395058035 2.5724810457731606 0.08098113181022536 1.154295576023657 0.23490338634472013 2.267838335704658e-11 10.644387907633543 2.131528766311422 ITLDNAYMEK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ITLDNAYMEK 10 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 35272800.0 2161100.0 17455700.0 15656000.0 False True 2833223.0281221685 14851377.60178566 14036067.302956441 1.0 5.241866755413534 4.954098976196521 21.43401274283727 -10.193197781961084 4.43025595839201 0.9989103674818701 5.097982865902265 0.9963153001166312 0.11748070424549775 20632829.282688264 466.2788256059313 229843.02914734796 0.0402167698177526 6.409176299458988e-11 10.193197781961084 4.099072498420394 ITLDNAYMEK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ITLDNAYMEK 10 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 58270000.0 20282300.0 2262600.0 35725100.0 False True 19638449.48846972 3166067.9793031234 26367624.57997302 1.0 0.16121781819700226 1.3426530742895046 24.227177693477245 -6.716017931968723 1.7735533159373449 0.4875311781834193 1.340422743737623 0.4936673818502856 0.3531470955484989 0.3631288881696436 2.230009829449819 0.15823511855671063 0.3991155008131625 1.9230123263152724e-07 6.716017931968723 0.8528915655542038 ITLDNAYMEK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ITLDNAYMEK 10 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 59293100.0 2161100.0 39788000.0 17344000.0 False True 2960117.071531554 38030034.5986789 13247704.410892494 1.0 12.847476528690907 4.47539880712832 21.497222804360163 -9.211408605565651 10.648794779063394 1.000048227087373 8.661437667909722 0.5275413942866264 3.4178864175723285 0.0 0.0 3.3093540963267505 1.1031180978567048 6.145983563034359e-10 9.211408605565651 7.661389440822349 ITLESFLAWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITLESFLAWK 10 0 Q8WU90;Q8WU90-2 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 0 1594620.0 533140.0 700750.0 360730.0 False True 698951.7029351045 596200.8315021063 323405.1199664967 1.0 0.8529928877753399 0.4627002389556005 19.41483324428172 -6.954160655130718 0.5111300017712523 1.0071167851348601 0.29142058470434706 0.9994886415079719 0.005126941071110248 0.0818568105019844 0.02937161654946863 0.005893779552948966 0.032214277177003516 1.1113205491929e-07 6.954160655130718 -0.7156962004305131 down ITLESFLAWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITLESFLAWK 10 0 Q8WU90;Q8WU90-2 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 0 34836600.0 5992600.0 13135000.0 15709000.0 False True 9091212.31774354 10790956.625776585 12604109.264500711 1.0 1.1869656376538047 1.3864057755972727 23.116041260682618 -6.970304850290104 0.2507995666911979 0.9373263461549904 1.6418923382906978 0.9999846619931764 0.0006178867961038622 0.07620393879259754 0.008675568784643138 0.00442426433598485 0.01908957294878056 1.0707674228962982e-07 6.970304850290104 0.7045659921357074 ITLESFLAWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITLESFLAWK 10 0 Q8WU90;Q8WU90-2 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 0 2748390.0 533140.0 823550.0 1391700.0 False True 730256.2655667643 787162.837884338 1063009.1229612029 1.0 1.0779268525322512 1.4556658711256432 19.47804330580461 -6.940499598981468 0.6549027345394022 0.995793745520994 1.5590436041485318 0.9982285671060811 0.008375373903336928 0.08753950203624461 0.053577987835382465 0.008183980098632273 0.03244034724081416 1.1468335803843707e-07 6.940499598981468 0.5632498586275378 ITLESFLAWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITLESFLAWK 10 0 Q8WU90;Q8WU90-2 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 0 4848600.0 3470600.0 0.0 1378000.0 False True 2885957.6736490945 0.0 1666133.4288478815 1.0 0.0 0.5773242775044481 21.460618710295233 -9.997255814555308 6.253062321390936 1.000000381815927 0.28866213875219804 0.6693327769235442 0.23569164933456999 1.2546407687679439e-06 2.0121454929154948e-07 0.22820758059116256 0.07606915272606515 1.0063387257253401e-10 9.997255814555308 -0.7113382430637291 ITLESFLAWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITLESFLAWK 10 0 Q8WU90;Q8WU90-2 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 0 21180800.0 5992600.0 8068700.0 7119500.0 False True 7757538.831805973 7619669.752042656 5823824.052238912 1.0 0.9822277293414178 0.7507308926848275 22.887167582775067 -6.922245009111042 0.8079046789384845 1.0047064039138998 0.7114020689592998 0.9947820814967765 0.008202275939111462 0.09686882696178731 0.09890194376014415 0.0071524408527681195 0.021907103500627908 1.1960655753660887e-07 6.922245009111042 -0.29330433495459995 ITLHITDASDMTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITLHITDASDMTR 13 0 O75312;H7C0E5;H7BZM7 O75312 ZPR1 Zinc finger protein ZPR1 0 8800600.0 1978800.0 2695800.0 4126000.0 False True 2710415.835059294 2576690.6421815283 3151523.777637364 1.0 0.9506624809566019 1.1627454860882702 21.37008277778711 -6.845434822891376 1.2568312842220237 0.9737402432753954 1.1705096151250236 0.9334056846882754 0.023383957776516685 0.16255257815458332 0.4964056779554396 0.0145738952294818 0.033642620754812606 1.4274640419538253e-07 6.845434822891376 0.19676937184962817 ITLIIGGSYGAGNYGMCGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITLIIGGSYGAGNYGMCGR 19 0 Q9HCC0-2;Q9HCC0;D6RD67 Q9HCC0-2 MCCC2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial 0 97382000.0 23532000.0 35836000.0 38014000.0 False True 35699764.419641055 29440785.812054016 30500516.23787188 1.0 0.8246773134406591 0.8543618349787012 25.08941121824919 -10.390604078020464 5.12497334722111 1.00012086045083 0.8395195742096696 0.9749808012860428 0.012118655171180135 1.6747803306720294e-05 1.991457023486942e-06 0.011742650530160327 0.003911279138028975 4.0681402975494203e-11 10.390604078020464 -0.16060128624116043 ITLIIGGSYGAGNYGMCGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITLIIGGSYGAGNYGMCGR 19 0 Q9HCC0-2;Q9HCC0;D6RD67 Q9HCC0-2 MCCC2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial 0 73330000.0 23532000.0 26336000.0 23462000.0 False True 30462637.885067947 24870378.44879539 19192156.74044939 1.0 0.8164223512956589 0.630022810659379 24.86053754034164 -6.9709352870868 0.2347770706688855 1.0714195969074596 0.36966871658024086 0.999988784838415 0.0005057990522351976 0.0760003951932598 0.007936104692253941 0.00462530828181662 0.0183457408188976 1.0692141877403085e-07 6.9709352870868 -0.7017508803272188 ITLNDLIPAFQNLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITLNDLIPAFQNLLK 15 0 P30154;P30154-2;P30154-4;P30154-3;P30154-5 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 0 1076740000.0 641400000.0 205820000.0 229520000.0 False True 973050692.6210175 169089812.9210003 184155271.39781016 1.0 0.1737728714477748 0.18925557814646635 29.857939725552257 -10.003987281609707 4.932973966498527 1.000009869995355 0.1815142247843216 0.99973170251768 0.006320788585378139 35139513.92386207 120359450.59469694 6730.368997374425 0.00231316572171062 9.908609620054411e-11 10.003987281609707 -0.8184956452110335 ITLPVDFVTADK(ub)FDENAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITLPVDFVTADKFDENAK 18 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 38196200.0 6114600.0 9492600.0 22589000.0 True False 9276295.237138249 7798571.363977679 18124274.24888958 1.0 0.8406989174682143 1.9538268010625486 23.145117306770036 -6.870614554534048 1.130911135816198 0.9095710516318642 2.0197627827776277 0.9652890703120712 0.09157210966544936 0.1362632453671191 0.3253555863712845 0.06281959288804949 0.14888084932358434 1.3470553635813657e-07 6.870614554534048 1.1101917311457634 ITLPVDFVTADK(ub)FDENAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITLPVDFVTADKFDENAK 18 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 46888100.0 6114600.0 9561500.0 31212000.0 True False 7915470.236785507 9029394.119765997 25531736.262164593 1.0 1.1407274425470972 3.2255488932939373 22.916243628862485 -6.920577560651381 0.8204312923360106 0.9549503817436349 3.5662529177315236 0.9943398526329555 0.07655710186892904 0.09783321016202766 0.1038619594463049 0.06616422405675675 0.19930106209682164 1.200666626813778e-07 6.920577560651381 2.611302535987889 up ITLPVDFVTADKFDENAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITLPVDFVTADKFDENAK 18 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 80608860.0 8204400.0 41269000.0 31135460.0 False True 10756047.851522632 35111826.06530208 27913861.271621656 1.0 3.2643798679578793 2.595178234324251 23.35864474281321 -9.97308020725767 5.334838697955876 0.9999935870755031 2.929779051147761 0.917271006640979 0.2732004229300154 2.083862423239325e-05 4.010592605013548e-06 0.2645260493429819 0.08817505734534214 1.0639465061438577e-10 9.97308020725767 1.9297854640722578 ITLPVDFVTADKFDENAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITLPVDFVTADKFDENAK 18 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 156972700.0 61828500.0 35392100.0 59752100.0 False True 59865788.11070986 49524350.09736329 44101232.48542354 1.0 0.8272562954617396 0.7366683689834183 25.83522843644752 -13.999999999999876 0.08126950464322527 1.92447814371285 0.47239344330287164 0.999881380779686 0.001189688609553133 12.245995927288943 0.08057821898285535 2.0236342830432177 0.23963342646567823 1.0000000000002864e-14 13.999999999999876 -1.4520847004099784 ITLPVDFVTADKFDENAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITLPVDFVTADKFDENAK 18 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 133296300.0 8204400.0 59445300.0 65646600.0 False True 11237788.395573331 56818810.08668057 50142225.11416604 1.0 5.05604911630673 4.461929994510088 23.4218548043361 -10.14322549833371 5.001224647244429 0.9998049551159824 4.758989555416857 0.9816090301860438 0.24254811583469768 0.000527527969081056 9.037277448188275e-05 0.23485716947831167 0.07828206776928476 7.190755161216647e-11 10.14322549833371 3.7591846003008746 ITLPVDFVTADKFDENAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITLPVDFVTADKFDENAK 18 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 88741500.0 61828500.0 11031000.0 15882000.0 False True 51413137.216969125 10971573.813517928 19202852.76992891 1.0 0.2134002009489651 0.37350089509011575 25.615633711881795 -10.185756576513958 7.842436115358197 1.0000002907304972 0.2934505481761362 0.9629189270546882 0.06536083468520255 3.3227974527057635e-07 3.451076680797326e-08 0.06328538246044985 0.021095118685833806 6.51993736297929e-11 10.185756576513958 -0.706549742554361 ITLPVDFVTADKFDENAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITLPVDFVTADKFDENAK 18 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 31256800.0 6119800.0 11734000.0 13403000.0 False True 7922201.739292819 11080992.584985029 10963791.526393443 1.0 1.3987263830994263 1.3839323823344258 22.917470009341194 -10.10199800919116 4.575768536655047 0.9999695567649945 1.391329382728211 0.998929263125148 0.006039625559913351 4204932.966720465 0.004709408194235275 1348.749074506087 0.0020675244680304064 7.906822524843068e-11 10.10199800919116 0.3913598259632164 ITLSK(ub)HQNVQLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITLSKHQNVQLPR 13 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;K7EK45;A0A087WUW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 1 26432300.0 6313700.0 9185600.0 10933000.0 True False 9578344.493297953 7546357.912579631 8772087.757895881 1.0 0.7878561809778173 0.9158250430472389 23.191344893584137 -10.276816839874671 5.174896454791295 1.0000268120653375 0.8518406120533636 0.6412251020764577 0.0522430691725471 1.616376440632116e-05 2.2588720581437798e-06 0.05059328301215068 0.0168613780716554 5.286681662161002e-11 10.276816839874671 -0.1481862000119739 ITLSK(ub)HQNVQLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITLSKHQNVQLPR 13 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;K7EK45;A0A087WUW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 1 13735400.0 4377300.0 6999700.0 2358400.0 True False 3639918.89726969 6961991.226768336 2851530.535990448 1.0 1.9126775687201545 0.7834049649099013 21.795474874745302 -6.691672827211439 1.860549421569981 1.5712994210204823 0.7872383640274636 0.37820688112593925 0.38586953299826326 0.41309723732726605 2.7738151673428497 0.16583653399991244 0.43092913384856013 2.0338886500939924e-07 6.691672827211439 -0.7840610569930186 ITLSK(ub)HQNVQLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITLSKHQNVQLPR 13 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20;K7EK45;A0A087WUW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 1 20715500.0 6313700.0 4229800.0 10172000.0 True False 8173209.111633234 3994407.911706969 8320800.37353384 1.0 0.4887196518710844 1.018057932922643 22.962471215676587 -10.925785993884656 12.16610036691277 1.0308402409673523 0.7533887923968664 0.22444516738550546 0.21610144831637862 0.11653343812293171 0.0007108604123605254 0.13488540049198056 0.06974644253505308 1.1863532002085464e-11 10.925785993884656 -0.27745144857048587 ITLVSSGSGTMGAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITLVSSGSGTMGAAK 15 0 O75955;A0A140T9R1;O75955-2;A0A140T9W4;A0A140T974 O75955 FLOT1 Flotillin-1 0 4499800.0 1232000.0 1533200.0 1734600.0 False True 1615163.93070497 1304452.5363667915 1555120.2314581159 1.0 0.8076285704308898 0.9628250123065547 20.62324916768786 -9.98118990513311 5.378226126618033 1.0000003805830955 0.8852267913988427 0.42170328500384013 0.0633586820828508 2.891850351955575e-07 5.473077372991497e-08 0.06134698398773888 0.020448926711894435 1.044263491424518e-10 9.98118990513311 -0.11477358918425273 ITMELFSNIVPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITMELFSNIVPR 12 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 0 1736320.0 1044200.0 692120.0 0.0 False True 1011052.4425661827 968487.1253581183 0.0 1.0 0.9578999907264671 0.0 19.947426400064558 -7.058396594422264 1.0402146799876515 1.0100702081176083 5.895699705289003e-20 0.9882620925609578 0.05003231327509317 0.08480708006049956 0.17628723432705137 0.04017700334845344 0.07175973015778103 8.741851114120552e-08 7.058396594422264 -1.0100702081176083 down ITNAK(ub)GDVEEVQGPGVVGEFPIISPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITNAKGDVEEVQGPGVVGEFPIISPGR 27 1 E9PJM3;Q9UK99-3;Q9UK99-2;Q9UK99;G3V1E0;Q49AF1 E9PJM3 FBXO3 F-box only protein 3 1 12810400.0 3447500.0 5380800.0 3982100.0 True False 2866749.000145579 5351812.562394829 4814738.698849881 1.0 1.8668577409892015 1.6795117740009256 21.45098416343961 -10.095594573904773 4.453195054647192 0.9999288624241919 1.773184757527085 0.9578236536699345 0.07648367089971266 26608011.171018064 2.8627198215244873 19801.050599908318 0.02618239487279693 8.024268018033151e-11 10.095594573904773 0.773255895102893 ITNDFYPEEDGKTK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITNDFYPEEDGKTK 14 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 10359000.0 3989200.0 3769400.0 2600400.0 True False 3317196.551524511 3749093.494032677 3144131.6171088736 1.0 1.1301993824603715 0.9478279529935901 21.6615330669818 -6.715009310587922 1.7771261974722197 1.0796297614439434 0.9481857025424724 0.48895069412548375 0.05482441091698035 0.36509768253188557 2.2505523660119318 0.02452119923352591 0.06192509168987394 1.9274835905433918e-07 6.715009310587922 -0.13144405890147104 ITNEK(ub)GECIVSDFTIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITNEKGECIVSDFTIGR 17 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 37271100.0 12575000.0 15934000.0 8762100.0 True False 16485946.776473226 13556709.310245538 7855481.943998124 1.0 0.8223191239214757 0.4764956511450425 23.97473340657321 -6.96057342792324 0.4272746878813215 1.0141403708835852 0.27147209675484396 0.9997908801278718 0.0031432802582087487 0.07949690197748661 0.020379061982488643 0.004498205551148772 0.028732690652260712 1.0950313983305093e-07 6.96057342792324 -0.7426682741287413 down ITNEK(ub)GECIVSDFTIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITNEKGECIVSDFTIGR 17 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 41752500.0 19033000.0 16732000.0 5987500.0 True False 18428807.833137464 23413174.856227297 4419194.128850262 1.0 1.2704660588042638 0.23979815563022797 24.135459409686355 -6.836973058615613 1.2964158789275944 1.1439843939303846 0.20788794017992585 0.9191155980876042 0.1240887143718956 0.17236561094463623 0.5640424573880866 0.0750905679450655 0.17287563469248543 1.4555493725393033e-07 6.836973058615613 -0.9360964537504588 down ITNEK(ub)GECIVSDFTIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITNEKGECIVSDFTIGR 17 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 116902000.0 37841000.0 33320000.0 45741000.0 True False 57407563.54766426 27373785.66965176 36700271.30100751 1.0 0.4768323889398981 0.6392933096792388 25.774737491249166 -10.928907329445678 11.591969834984038 1.0662607609005919 0.5580628493095685 0.9079738207362602 0.06632439315902099 0.03166825149011561 0.00019421868068708703 0.017905812798638558 0.021406105846016803 1.1778572800578009e-11 10.928907329445678 -0.5081979115910233 ITNEK(ub)GECIVSDFTIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITNEKGECIVSDFTIGR 17 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 37482100.0 12575000.0 15352000.0 9555100.0 True False 17224317.326597247 14673697.877724895 7298382.173461654 1.0 0.8519175302852923 0.4237254827041373 24.037943468096103 -6.952275083743535 0.5332814149640572 1.0065980780230752 0.24949719425485625 0.9993679472664607 0.006143156544237095 0.08258482769914234 0.03227941420615028 0.006820909237222529 0.03542480940788598 1.1161560464322859e-07 6.952275083743535 -0.7571008837682189 down ITNEK(ub)GECIVSDFTIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITNEKGECIVSDFTIGR 17 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 95353000.0 37841000.0 26403000.0 31109000.0 True False 48985920.457625985 24933649.839897685 25447481.20529535 1.0 0.5089962504933616 0.5194856188791643 25.545863813341615 -10.040855742802096 5.150720341403782 1.0000055736164353 0.5142409346845119 0.9996504035230516 0.004282266717651666 2.740839080930575e-07 5.104121698979818e-08 0.004146334473361925 0.0013820956392465976 9.102155636977384e-11 10.040855742802096 -0.48576463893192334 ITNNINVLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITNNINVLIK 10 0 G3V1C3;Q9BZZ5-2;Q9BZZ5;Q9BZZ5-3;Q9BZZ5-6;Q9BZZ5-1;Q9BZZ5-5;H0YER7 G3V1C3 API5 Apoptosis inhibitor 5 0 16997700.0 3846900.0 6268300.0 6882500.0 False True 5043323.153432587 5333094.073642026 6170364.921601797 1.0 1.0574563460230015 1.2234720508445156 22.265943238981485 -6.952291696864373 0.5330900229232812 0.9974384124276906 1.2910664218167232 0.9993690766433849 0.002380002278584203 0.08257834646468294 0.032253201746966456 0.0026433083223788077 0.013734302577051109 1.1161133507928292e-07 6.952291696864373 0.29362800938903255 ITNNINVLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITNNINVLIK 10 0 G3V1C3;Q9BZZ5-2;Q9BZZ5;Q9BZZ5-3;Q9BZZ5-6;Q9BZZ5-1;Q9BZZ5-5;H0YER7 G3V1C3 API5 Apoptosis inhibitor 5 0 13482500.0 2237400.0 2155400.0 9089700.0 False True 2166374.961690843 3016062.46026251 6708834.884845132 1.0 1.3922162661575865 3.096802263449779 21.046851539211428 -6.94297315435914 0.6312969272247487 0.9814042256974888 3.5996868411978156 0.9985279817330484 0.034921192675059734 0.08643604261451517 0.04862661463267954 0.03481442376290246 0.14489851347845736 1.1403202735647316e-07 6.94297315435914 2.618282615500327 up ITNNINVLIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITNNINVLIK 10 0 G3V1C3;Q9BZZ5-2;Q9BZZ5;Q9BZZ5-3;Q9BZZ5-6;Q9BZZ5-1;Q9BZZ5-5;H0YER7 G3V1C3 API5 Apoptosis inhibitor 5 0 25662000.0 0.0 25662000.0 0.0 False True 0.0 21082415.601878833 0.0 0.0 ITNNINVLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITNNINVLIK 10 0 G3V1C3;Q9BZZ5-2;Q9BZZ5;Q9BZZ5-3;Q9BZZ5-6;Q9BZZ5-1;Q9BZZ5-5;H0YER7 G3V1C3 API5 Apoptosis inhibitor 5 0 13804200.0 3846900.0 3964700.0 5992600.0 False True 5269202.888563569 3789526.4444903582 4577271.301471082 1.0 0.7191840065060423 0.8686838214952255 22.329153300504377 -10.138131989686435 4.7210920115811925 1.0000175811904017 0.7939339139986609 0.7169709130143482 0.0610330439007688 1.1295239117441074e-05 2.0619711561481582e-06 0.05910003100479146 0.019698330215375832 7.275586531370118e-11 10.138131989686435 -0.20608366719174087 ITNNINVLIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITNNINVLIK 10 0 G3V1C3;Q9BZZ5-2;Q9BZZ5;Q9BZZ5-3;Q9BZZ5-6;Q9BZZ5-1;Q9BZZ5-5;H0YER7 G3V1C3 API5 Apoptosis inhibitor 5 0 4929600.0 2237400.0 2692200.0 0.0 False True 1860497.2336260262 2677696.5842401376 0.0 1.0 1.4392370683730749 0.0 20.827256814645704 -6.849368578257716 1.4076431445475857 1.2338262492349634 9.75625831799698e-22 0.8942639218761793 0.19583375044819498 0.17519285489148254 0.6975207330061729 0.11184937887792111 0.23646711271503645 1.4145927298524848e-07 6.849368578257716 -1.2338262492349634 down ITNQVHGLK(ub)GLNSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITNQVHGLKGLNSK 14 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 66287000.0 29567000.0 24432000.0 12288000.0 True False 38762623.32723534 20786840.835190088 11016555.63481916 1.0 0.5362599084098848 0.28420562617284784 25.208162875137994 -9.232850451972409 0.1871526780773714 1.4663098991507872 7.16157464711926e-23 0.9996236634938684 0.005750963580879499 0.6652306041475095 0.06720221926210897 0.3294520147247149 0.150015171224881 5.849914895647908e-10 9.232850451972409 -1.4663098991507872 ITNQVHGLK(ub)GLNSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITNQVHGLKGLNSK 14 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 94080000.0 34113000.0 35213000.0 24754000.0 True False 33030101.48751216 49273734.53336912 18270184.795918047 1.0 1.4917827168044961 0.5531374102143022 24.9772780666326 -6.7643421581515675 1.5961551053220437 1.28410731989912 0.548955351318259 0.7084364148768096 0.20699422903583709 0.27567893466543647 1.3851606914023908 0.10227661936755629 0.2447418461316999 1.720512538072357e-07 6.7643421581515675 -0.735151968580861 ITNQVHGLK(ub)GLNSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITNQVHGLKGLNSK 14 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 178765000.0 57610000.0 77308000.0 43847000.0 True False 87398581.8551555 63511783.389839105 35180621.23117716 1.0 0.7266912350488288 0.4025308018095938 26.381106534702475 -6.968865589337859 0.28397585369083334 1.0680805081583347 0.05120960594468273 0.9999721324161581 0.0012891661864051697 0.07667252365762639 0.010341483714018355 0.005853787529138001 0.029607446552974002 1.0743218548999729e-07 6.968865589337859 -1.016870902213652 down ITNQVHGLK(ub)GLNSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITNQVHGLKGLNSK 14 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 65756900.0 29567000.0 23707900.0 12482000.0 True False 40498718.91813133 22660406.586458728 9534008.67485933 1.0 0.5595339109927656 0.23541506816875982 25.271372936660885 -8.04706812685789 0.276185054033022 1.1519782939890917 7.253339996324361e-23 0.9993824632684097 0.007786656716884854 0.09534266508992462 0.054037645419991995 0.06743968436970271 0.09428181778692851 8.9728802778283e-09 8.04706812685789 -1.1519782939890917 down ITNQVHGLK(ub)GLNSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITNQVHGLKGLNSK 14 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 113523600.0 34113000.0 59989000.0 19421600.0 True False 28366470.962136682 59665827.35011576 23482566.76466761 1.0 2.103392678975019 0.8278282764187317 24.757683342066876 -6.677892234576552 1.90920429631047 1.6994384806864515 0.8327400970563484 0.3145755217421081 0.467859833994432 0.44322487739293703 3.1216633971993706 0.19675934892789376 0.5203778416141278 2.0994607772124957e-07 6.677892234576552 -0.8666983836301031 ITNQVHGLK(ub)GLNSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITNQVHGLKGLNSK 14 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 199114000.0 57610000.0 104054000.0 37450000.0 True False 74577280.6628745 98263303.42918289 30634484.26944975 1.0 1.31760373341287 0.4107750242051931 26.152232856794924 -6.8120772775982585 1.4057928831510327 1.1726694677211034 0.39414628306538946 0.8651836563338543 0.13794935158178373 0.2039789300907788 0.794101691271913 0.07715115177075285 0.17830365552621769 1.541426149880682e-07 6.8120772775982585 -0.7785231846557139 down ITNSLTVLCSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITNSLTVLCSEK 12 0 O75822-3;O75822;H0YGJ7;O75822-2;H0YLP3 O75822-3 EIF3J Eukaryotic translation initiation factor 3 subunit J 0 22403400.0 6103600.0 7866900.0 8432900.0 False True 8001878.707346488 6693189.184936022 7560344.402088739 1.0 0.8364522170013695 0.9448211699519541 22.931907329770254 -10.290941624726448 5.245169083736153 1.000020880472361 0.890636693483675 0.5758963069926653 0.044241439781477966 1.0804739462255795e-05 1.4606025852485063e-06 0.04284476602678589 0.01427886329048567 5.117506173828137e-11 10.290941624726448 -0.1093841869886859 ITNSLTVLCSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITNSLTVLCSEK 12 0 O75822-3;O75822;H0YGJ7;O75822-2;H0YLP3 O75822-3 EIF3J Eukaryotic translation initiation factor 3 subunit J 0 28187500.0 3017400.0 22721000.0 2449100.0 False True 4577616.401488388 18666260.03001674 1965034.3115213383 1.0 4.077724822889813 0.4292702007277014 22.12616514124846 -6.683042391933916 1.8907633216560067 2.941934736151897 0.44270449721575894 0.3382261814635963 1.303548943666833 0.43180932406344896 2.9870886130210277 0.5526382638620351 1.45205754641263 2.0747109928832097e-07 6.683042391933916 -2.4992302389361383 ITNSLTVLCSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITNSLTVLCSEK 12 0 O75822-3;O75822;H0YGJ7;O75822-2;H0YLP3 O75822-3 EIF3J Eukaryotic translation initiation factor 3 subunit J 0 21278300.0 6103600.0 6069400.0 9105300.0 False True 8360265.863587997 5801233.8391781915 6954815.669539875 1.0 0.6939054252382904 0.8318892943142671 22.995117391293146 -10.057874343212092 4.502679657005265 1.0000114631157024 0.7628973597619779 0.7974439224084995 0.05633167872756557 17374717.61657995 19405414.728809085 1874.3505420242122 0.019283832392448456 8.752369756770379e-11 10.057874343212092 -0.23711410335372451 ITNSLTVLCSEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITNSLTVLCSEK 12 0 O75822-3;O75822;H0YGJ7;O75822-2;H0YLP3 O75822-3 EIF3J Eukaryotic translation initiation factor 3 subunit J 0 9807500.0 3017400.0 3946100.0 2844000.0 False True 3906083.781846162 3726496.0660993177 2326421.181904271 1.0 0.9540235883875577 0.5955891659867871 21.89729146334091 -6.930580068985678 0.7420179799233314 1.005335172598095 0.5209062364837289 0.9966509508028741 0.010461992667486868 0.09233792205508361 0.07621364442067463 0.009564441109287005 0.032329355341448325 1.1733293409189988e-07 6.930580068985678 -0.4844289361143661 ITPAHDQNDYEVGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITPAHDQNDYEVGQR 15 0 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 13103900.0 3022200.0 1268200.0 8813500.0 False True 2926261.915268642 1774598.8735756336 6504979.9506675145 1.0 0.6064388373153258 2.2229657286402995 21.48062747309597 -6.842361892260368 1.2714219996760339 0.7906640390154973 2.27865758607273 0.9284392844384503 0.1841234631532935 0.16605231247572774 0.5204021608312893 0.11351099793333251 0.2616904713160554 1.4376001444527197e-07 6.842361892260368 1.4879935470572325 up ITPEFSK(ub)WASDEMPSTSNGESSK ddPTM_RPMI8226_Bortezomib_1h_R1 2 ITPEFSKWASDEMPSTSNGESSK 23 1 Q5TDE7;Q5TDE8;Q5VTB9-3;Q5VTB9 Q5TDE7 RNF220 E3 ubiquitin-protein ligase RNF220 1 61929200.0 20672800.0 28538800.0 12717600.0 True False 27102240.99567999 24280922.28337108 11401704.747833353 1.0 0.8959009067641817 0.42069232391707934 24.691908812458003 -6.941854711711592 0.6420800083755122 1.005210363637732 0.2852362973220202 0.9983968444574635 0.010096297482036156 0.08693067708028895 0.05083288478955138 0.00997200950181771 0.0405777814848165 1.1432607357220421e-07 6.941854711711592 -0.7199740663157119 down ITPEFSK(ub)WASDEMPSTSNGESSK ddPTM_RPMI8226_Bortezomib_2h_R1 2 ITPEFSKWASDEMPSTSNGESSK 23 1 Q5TDE7;Q5TDE8;Q5VTB9-3;Q5VTB9 Q5TDE7 RNF220 E3 ubiquitin-protein ligase RNF220 1 109069300.0 41419800.0 32010600.0 35638900.0 True False 40104951.12105228 44792599.51307372 26304002.94591762 1.0 1.1168845307371726 0.6558791922354412 25.25727701851909 -6.839486266396238 1.284668019392959 1.0621883034763022 0.6408602046608656 0.9235772026829668 0.05409439707337424 0.16940658367167807 0.543299337854213 0.03301935254982083 0.0760647148989834 1.4471506153132393e-07 6.839486266396238 -0.42132809881543665 ITPEFSK(ub)WASDEMPSTSNGESSK ddPTM_RPMI8226_Bortezomib_8h_R1 2 ITPEFSKWASDEMPSTSNGESSK 23 1 Q5TDE7;Q5TDE8;Q5VTB9-3;Q5VTB9 Q5TDE7 RNF220 E3 ubiquitin-protein ligase RNF220 1 146424300.0 46108000.0 51680300.0 48636000.0 True False 69949206.94632031 42457546.684973106 39023073.28208389 1.0 0.6069768127257744 0.5578772796099114 26.0598043650455 -13.999999999999998 0.29332448680188583 4.450931740297387 0.5449400715600428 0.9996349043334263 0.0037806721483620073 16.166384831845217 0.17182540168145935 33.72980058338747 0.01826949645171147 1.0000000000000041e-14 13.999999999999998 -3.905991668737344 ITPEFSK(ub)WASDEMPSTSNGESSK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 ITPEFSKWASDEMPSTSNGESSK 23 1 Q5TDE7;Q5TDE8;Q5VTB9-3;Q5VTB9 Q5TDE7 RNF220 E3 ubiquitin-protein ligase RNF220 1 68895600.0 20672800.0 27870600.0 20352200.0 True False 28316092.821413897 26639184.73625066 15545429.526716216 1.0 0.940778973436085 0.5489962765964683 24.755118873980894 -6.93380539059902 0.714870532272741 1.005199680817766 0.46017406846054476 0.9972346180791496 0.010523295017764164 0.09070973047509899 0.0683507458024003 0.009814247321078618 0.034737791256349015 1.1646477966566911e-07 6.93380539059902 -0.5450256123572211 ITPEFSK(ub)WASDEMPSTSNGESSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITPEFSKWASDEMPSTSNGESSK 23 1 Q5TDE7;Q5TDE8;Q5VTB9-3;Q5VTB9 Q5TDE7 RNF220 E3 ubiquitin-protein ligase RNF220 1 87914000.0 32331000.0 41457000.0 14126000.0 True False 26884659.006151337 41233662.91242982 17079681.28875553 1.0 1.533724601193393 0.6352946966836223 24.680279837396267 -6.7457870475684425 1.6656408440471646 1.315419015285113 0.6340885072073302 0.6305760911435037 0.2242424518605545 0.3074440282945976 1.6768565078809596 0.10641720950167873 0.2594846945620785 1.7956138742764126e-07 6.7457870475684425 -0.6813305080777828 ITPEFSK(ub)WASDEMPSTSNGESSK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 ITPEFSKWASDEMPSTSNGESSK 23 1 Q5TDE7;Q5TDE8;Q5VTB9-3;Q5VTB9 Q5TDE7 RNF220 E3 ubiquitin-protein ligase RNF220 1 165566000.0 46108000.0 78610000.0 40848000.0 True False 59687714.92455859 74235284.39625642 33414083.13587399 1.0 1.2437280349915392 0.559815083859505 25.83093068713795 -6.810362959198597 1.4131489056921365 1.1327699743334476 0.5477653629088151 0.8607465490459774 0.10561367540235192 0.20630089696279738 0.8119330309630888 0.058766623847426584 0.13590805431390393 1.5475227447839282e-07 6.810362959198597 -0.5850046114246326 ITPENLPQILLQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITPENLPQILLQLK 14 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 0 84786300.0 47500000.0 27766000.0 9520300.0 False True 62272959.99065429 23623421.0310203 8535230.681166088 1.0 0.37935278866727423 0.1370615863200822 25.892102519985993 -9.885116326493405 0.24647728920808995 1.5304762119626476 1.1084706657400364e-24 0.9990990703138718 0.010907786831654406 1.3354266438124565 0.10961130423582005 0.6080778888144502 0.1085232183660102 1.3028177698242975e-10 9.885116326493405 -1.5304762119626476 ITPENLPQILLQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITPENLPQILLQLK 14 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 0 332627000.0 150600000.0 91399000.0 90628000.0 False True 145819285.43427223 127895097.33948854 66889808.01827835 1.0 0.87707944088875 0.4587171567812188 27.119606296050645 -6.948585028494515 0.5741713226769751 1.005117862117984 0.3101921465327559 0.9990854860099497 0.007006528495329344 0.08405902290363185 0.038353100411210615 0.007388152962528858 0.03489428964635159 1.125680055661929e-07 6.948585028494515 -0.694925715585228 down ITPENLPQILLQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITPENLPQILLQLK 14 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 0 283882000.0 62314000.0 131400000.0 90168000.0 False True 94534893.7636202 107950643.367114 72346255.27796173 1.0 1.141913203362128 0.7652862598953138 26.494343604845756 -6.804606507821569 1.436839789355857 1.0778488700467925 0.759464528813773 0.845340611166321 0.061076556825120344 0.21424643865696316 0.872661299718658 0.033431936108533566 0.07754943406174757 1.5681712669868193e-07 6.804606507821569 -0.3183843412330195 ITPENLPQILLQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITPENLPQILLQLK 14 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 0 179769000.0 47500000.0 29119000.0 103150000.0 False True 65062033.639234096 27832426.296343938 78788094.44093403 1.0 0.4277829133142906 1.2109688251955095 25.955312581508885 -6.710855198824316 1.7924407678541976 0.6485172219566375 1.209153443484981 0.4690558977343354 0.24109704396757342 0.3733475900445986 2.338824067805578 0.10702568854138354 0.2715850259147865 1.9460088059424507e-07 6.710855198824316 0.5606362215283436 ITPENLPQILLQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITPENLPQILLQLK 14 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 0 290115000.0 150600000.0 65075000.0 74440000.0 False True 125230572.71121807 64724428.05862379 90005059.82832816 1.0 0.5168420670556098 0.7187147505575974 26.90001157148492 -10.231449284971983 5.522847045737786 1.000021763421343 0.6177784088065827 0.8269850590408355 0.08241417793111294 2.2085995407199503e-05 3.07354643948986e-06 0.07980172203704662 0.02659906155153721 5.868818991429217e-11 10.231449284971983 -0.38224335461476033 ITPENLPQILLQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITPENLPQILLQLK 14 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 0 171354000.0 62314000.0 64196000.0 44844000.0 False True 80666701.392577 60623436.16718073 36682852.138296485 1.0 0.7515298768961356 0.4547459051260036 26.265469926938206 -6.96876590134963 0.28613125847625437 1.0607394714983556 0.13641607905191114 0.9999710917492107 0.0011983860261879534 0.07670521466753019 0.010456542385969523 0.005295470069730863 0.027036506518926036 1.0745684831242625e-07 6.96876590134963 -0.9243233924464445 down ITPENLPQILLQLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITPENLPQILLQLKR 15 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 1 6784800.0 2288500.0 2977300.0 1519000.0 True False 3000245.6618655217 2533098.445424503 1361828.4512768793 1.0 0.8442970112818857 0.45390564798954114 21.51664920359362 -6.955399230458492 0.4960419947021274 1.0080938138635045 0.2733838317776059 0.999559694355517 0.004819943607681834 0.0813874111131941 0.0275300193095775 0.005695530143644149 0.03220029851394129 1.1081556613963331e-07 6.955399230458492 -0.7347099820858987 down ITPENLPQILLQLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITPENLPQILLQLKR 15 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 1 33524000.0 10690000.0 10145000.0 12689000.0 True False 10350651.801410161 14195951.405476112 9365370.23815965 1.0 1.3715031360191319 0.9048097083976607 23.303218284211844 -6.694620554041089 1.8498326039624617 1.2318900987788248 0.9063192142498515 0.39220683880629237 0.15697511243060702 0.40681351041379277 2.702375505289248 0.06779468882302009 0.17553151854011537 2.020130594309806e-07 6.694620554041089 -0.3255708845289733 ITPENLPQILLQLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITPENLPQILLQLKR 15 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 1 79592000.0 12970000.0 21310000.0 45312000.0 True False 19676438.234010905 17507064.004210044 36356063.339044906 1.0 0.8897476157015513 1.8476953454006282 24.229965756474947 -6.878257025205061 1.0895284503951919 0.9331298745606156 1.9133411222353638 0.9722496763729629 0.07129268544281017 0.1291826492234314 0.28174149813392557 0.05048398209529902 0.12155521032195936 1.3235579920833962e-07 6.878257025205061 0.9802112476747482 ITPENLPQILLQLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITPENLPQILLQLKR 15 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 1 11634300.0 2288500.0 2270500.0 7075300.0 True False 3134620.294387098 2170181.8024605536 5404259.860377524 1.0 0.6923268525845112 1.7240556599644556 21.57985926511651 -6.826804529644276 1.342306212025182 0.8352068923102138 1.7500150158494958 0.8992941514574472 0.1372453534098331 0.18479034518647244 0.6523110632335677 0.08030826217330533 0.1848376845190331 1.4900315708386075e-07 6.826804529644276 0.914808123539282 ITPENLPQILLQLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITPENLPQILLQLKR 15 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 1 30794900.0 10690000.0 10607000.0 9497900.0 True False 8889208.647296954 10549857.985675335 11483866.976672184 1.0 1.186816330257177 1.2918885619997476 23.08362355964612 -13.39708573984697 0.07098514984916843 3.197569491310477e-17 1.676099758443059 0.9999304661197257 0.0010065526801174044 10.107224551798287 0.06702335870479836 1.7769303830108991 0.3348923963901247 4.0078758501121865e-14 13.39708573984697 1.676099758443059 ITPENLPQILLQLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITPENLPQILLQLKR 15 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 1 78812000.0 12970000.0 18204000.0 47638000.0 True False 16789920.676922124 17190931.39739794 38968372.80715742 1.0 1.0238840151893633 2.3209384699904954 24.001092078567396 -6.910888838352002 0.8896430924764505 0.9609603703931073 2.491797069333848 0.9912530358605754 0.05771850840583635 0.10383373778068151 0.13559463947177322 0.047463502006211834 0.13184474160497256 1.227753445676427e-07 6.910888838352002 1.5308366989407407 up ITPSYVAFTPEGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITPSYVAFTPEGER 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 93018600.0 8127600.0 44942000.0 39949000.0 False True 10655362.30779035 38236828.78254393 35815460.69786712 1.0 3.5885057380534318 3.3612616505476978 23.345076313246352 -9.70053240886187 7.52839539826451 1.0000000082887963 3.4748836941906482 0.9937165324503784 0.0927720102423959 8.279010041470515e-10 0.0 0.08982611400418795 0.029942037555224857 1.992817788257903e-10 9.70053240886187 2.474883685901852 ITPSYVAFTPEGER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITPSYVAFTPEGER 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 81369000.0 28788000.0 11014000.0 41567000.0 False True 27874140.697754502 15411947.637251237 30679355.716729645 1.0 0.5529120271138188 1.1006386187611203 24.732423994618582 -6.689703620902111 1.8673399712438403 0.7196195469078052 1.0987422639697122 0.3689900549941779 0.1890995687779081 0.41736610055018664 2.821382687304967 0.08101628251592496 0.21106090051255882 2.0431317799672873e-07 6.689703620902111 0.37912271706190703 ITPSYVAFTPEGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITPSYVAFTPEGER 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 113297600.0 8127600.0 56061000.0 49109000.0 False True 11132593.360131344 53584039.651064076 37510465.631602876 1.0 4.8132576047340585 3.3694274476904384 23.408286374769244 -9.54993338417122 10.818582043571034 1.0000000000000004 4.091342526212411 0.8593974256559241 0.5894411933332288 0.0 0.0 0.5707239813370553 0.1902413271123517 2.818815272274109e-10 9.54993338417122 3.09134252621241 ITPSYVAFTPEGER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITPSYVAFTPEGER 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 33499700.0 28788000.0 4711700.0 0.0 False True 23938497.524638414 4686317.136900773 0.0 1.0 0.19576488173818918 0.0 24.51282927005286 -9.503815306696005 0.44902046312734184 1.212623410958763 2.2197455641360055e-22 0.9977885663614197 0.020348427082574456 0.9262318138599378 0.2096803676124942 0.36663159379208526 0.04467824936655405 3.1346185065316977e-10 9.503815306696005 -1.212623410958763 ITPSYVAFTPEGER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITPSYVAFTPEGER 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 31711200.0 8062700.0 16642000.0 7006500.0 False True 10437324.089577483 15715858.070506282 5731388.892760995 1.0 1.5057363300809874 0.5491243582715087 23.315248546853763 -6.763060597645622 1.6008761594159964 1.2926386904838898 0.5450816120137127 0.7033655432575812 0.21281827221955338 0.277805086359074 1.403838984339699 0.10485476283353475 0.25123435695509483 1.7255971004962537e-07 6.763060597645622 -0.747557078470177 ITQDIFQQLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITQDIFQQLLK 11 0 P56192;P56192-2;H0YHV5 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 30203700.0 7383700.0 11452000.0 11368000.0 False True 9680102.203852503 9743406.23954637 10191748.409556018 1.0 1.006539604062101 1.0528554549248343 23.20659084907743 -6.932434752249108 0.7265213115490026 0.9993553919525422 1.0629818157841024 0.9969955696087254 0.0012895581575864093 0.09139303863162578 0.07162838902223541 0.0011923519233072689 0.004136104625717015 1.1683292447079939e-07 6.932434752249108 0.06362642383156025 ITQDIFQQLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITQDIFQQLLK 11 0 P56192;P56192-2;H0YHV5 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 28787300.0 9530100.0 8289200.0 10968000.0 False True 9227572.192013009 11599120.787606938 8095151.767052973 1.0 1.2570067777574951 0.8772786165856052 23.137519688779804 -6.724392810125444 1.7433245033779288 1.1556192239425054 0.8777110775343078 0.5332529546995228 0.10809519577017339 0.34684712171162196 2.0623266231728787 0.049187272028058476 0.1228536641723358 1.8862844730940871e-07 6.724392810125444 -0.2779081464081976 ITQDIFQQLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITQDIFQQLLK 11 0 P56192;P56192-2;H0YHV5 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 36751700.0 7383700.0 12631000.0 16737000.0 False True 10113653.426989738 12072920.654868642 12784065.309335086 1.0 1.1937249720907301 1.264040279966384 23.26980091060032 -13.999999999998032 0.14098595954282808 0.07377113353477915 1.350034116920712 0.9995990299153326 0.0022356924227146754 11.934998779447188 0.11771143638526695 3.039583655156977 0.07692860221319231 1.000000000004532e-14 13.999999999998032 1.2762629833859327 ITQDIFQQLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITQDIFQQLLK 11 0 P56192;P56192-2;H0YHV5 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 19010800.0 9530100.0 3944500.0 5536200.0 False True 7924700.405014478 3923250.195578057 6693793.823503361 1.0 0.4950660586607866 0.8446746856534486 22.91792496421408 -10.095878108422486 5.84051185724574 1.0000017304134186 0.6698703721570985 0.5431484597743419 0.14272712430124998 3.2158385152101864e-06 4.978523895702329e-07 0.1381956665958484 0.046064981289223456 8.01903098524388e-11 10.095878108422486 -0.33013135825632 ITQDIFQQLLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITQDIFQQLLKR 12 1 P56192;P56192-2;H0YHV5 P56192 MARS Methionine--tRNA ligase, cytoplasmic 1 6075100.0 1753100.0 2243700.0 2078300.0 True False 2298331.07704455 1908948.7058740982 1863257.4524613179 1.0 0.8305803828440753 0.8107001950551449 21.132155204038472 -13.999999999999972 0.30234315700890435 2.566391241845014 0.8059263863500541 0.9996550481019738 0.001577562787453133 16.742635730826088 0.1746962149975368 16.427977173178665 0.007112964505469354 1.0000000000000655e-14 13.999999999999972 -1.76046485549496 ITQDIFQQLLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITQDIFQQLLKR 12 1 P56192;P56192-2;H0YHV5 P56192 MARS Methionine--tRNA ligase, cytoplasmic 1 10632300.0 2755400.0 2755700.0 5121200.0 True False 2667931.3352297083 3856065.380785659 3779804.087293185 1.0 1.4453390647153415 1.4167546358413847 21.34729010556243 -10.183217980512941 4.898054691192647 0.9999569605686817 1.4310468502793818 0.9967126840898253 0.011669544225242995 5.485346597827605e-06 9.14715194284498e-07 0.011300113056994214 0.003766329203008157 6.55816017372183e-11 10.183217980512941 0.43108988971070017 ITQDIFQQLLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITQDIFQQLLKR 12 1 P56192;P56192-2;H0YHV5 P56192 MARS Methionine--tRNA ligase, cytoplasmic 1 18001700.0 0.0 6445700.0 11556000.0 True False 0.0 5295414.474516032 9271951.534825265 0.0 ITQDIFQQLLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITQDIFQQLLKR 12 1 P56192;P56192-2;H0YHV5 P56192 MARS Methionine--tRNA ligase, cytoplasmic 1 8612300.0 1753100.0 2501200.0 4358000.0 True False 2401268.4457461345 2390688.7136376705 3328730.1558273444 1.0 0.9955941068866306 1.3862382449260162 21.195365265561364 -6.904349949087627 0.9333560187017368 0.9856391645463305 1.4310667566674982 0.9886088520418936 0.01954446108364438 0.10827428893644342 0.15991194146367663 0.01556708541401311 0.041462581399140955 1.2463787929843064e-07 6.904349949087627 0.44542759212116767 ITQDIFQQLLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITQDIFQQLLKR 12 1 P56192;P56192-2;H0YHV5 P56192 MARS Methionine--tRNA ligase, cytoplasmic 1 9637400.0 2755400.0 3688900.0 3193100.0 True False 2291237.1849169363 3669027.1635106797 3860762.446773705 1.0 1.6013301406173241 1.6850121289008622 21.127695380996705 -11.458333211949794 0.3381144605185315 2.1365526656295297e-11 1.7004473023404207 0.9994688030609304 0.00703213993126196 3.8063864872696183 0.1749157758505573 2.8161654977557804 0.02598685407965067 3.4807015612701864e-12 11.458333211949794 1.7004473023190552 ITQDIFQQLLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITQDIFQQLLKR 12 1 P56192;P56192-2;H0YHV5 P56192 MARS Methionine--tRNA ligase, cytoplasmic 1 5422700.0 0.0 0.0 5422700.0 True False 0.0 0.0 4435824.241600667 0.0 ITQRMVCAGYK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITQRMVCAGYK 11 1 H0YAC1;P03952 H0YAC1 KLKB1 Plasma kallikrein;Plasma kallikrein heavy chain;Plasma kallikrein light chain 1 18524580.0 803980.0 4874000.0 12846600.0 True False 1101233.132742558 4658650.563837365 9812497.664032029 1.0 4.2303944780840945 8.91046352700501 20.070688491312065 -6.96582843203505 0.34353811866271255 0.512740207010044 12.784487356578992 0.9999292174166264 0.027321649376567864 0.07768096086774928 0.01387497280527045 0.06537581667089332 0.4040496909976887 1.0818612560035493e-07 6.96582843203505 12.271747149568949 ITSAVWGPLGECIIAGHESGELNQYSAK(ub)SGEVLVNVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVK 37 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 461279400.0 106328700.0 187899500.0 167051200.0 True False 161308411.56921166 154367366.15950575 134033457.09885807 1.0 0.9569703443101121 0.8309142455435383 27.265246430157728 -6.95198378099142 0.5366216616763956 1.001898243410621 0.780198645013329 0.9993479116868578 0.0018321829615659004 0.08269876278485451 0.03274008762122829 0.0020246753947683865 0.0104337898547768 1.116904958540436e-07 6.95198378099142 -0.22169959839729192 ITSAVWGPLGECIIAGHESGELNQYSAK(ub)SGEVLVNVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVK 37 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 420438100.0 106328700.0 132039400.0 182070000.0 True False 137644598.20202386 124691291.31803922 148935128.1959604 1.0 0.9058930967637916 1.0820266842391097 27.036372752250177 -6.761569999813407 1.6066452351244291 0.9454444453278882 1.082718835668857 0.6973255286072031 0.03959083553914626 0.28028073234456125 1.426288478933833 0.0194397991137056 0.04664316881423026 1.7315299193523773e-07 6.761569999813407 0.1372743903409689 ITSCIFQLLQEAGIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITSCIFQLLQEAGIK 15 0 P22234;E9PBS1 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 278289000.0 191800000.0 54200000.0 32289000.0 False True 251451657.39384225 46113571.269945316 28948044.017958645 1.0 0.1833894107037792 0.1151236954171993 27.905705821785816 -13.84160118754219 0.3529413526713824 9.999197402858208 0.10597746508274575 0.9997557276802642 0.006283120807465002 18.686909082328633 0.19110816346059492 125.63965522201796 0.020175941016556453 1.4401204332804706e-14 13.84160118754219 -9.893219937775463 ITSCIFQLLQEAGIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITSCIFQLLQEAGIK 15 0 P22234;E9PBS1 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 1169300000.0 749270000.0 188500000.0 231530000.0 False True 725484833.9796613 263769033.01451385 170885347.24888542 1.0 0.3635762191851808 0.23554640875328914 29.43437021464381 -13.999999999999998 0.22543279753377835 4.934490377232343 0.17052899229003488 0.9995039083946603 0.007445928423716874 13.153168771734268 0.15036981096272073 23.105420070154327 0.06839997201078342 1.0000000000000041e-14 13.999999999999998 -4.763961384942308 ITSCIFQLLQEAGIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITSCIFQLLQEAGIK 15 0 P22234;E9PBS1 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 2326680000.0 866040000.0 648450000.0 812190000.0 False True 1313845996.004841 532729031.13702506 651660290.5044768 1.0 0.40547296468304045 0.4959944258962263 30.291149032370114 -10.770504115047256 7.0966009257390965 1.0129164226642458 0.45073369528963336 0.9800363181372738 0.036955231790574 0.007399977306764162 0.0002393064798575283 0.03506077590851851 0.011927249773343996 1.6962735295741653e-11 10.770504115047256 -0.5621827273746124 ITSCIFQLLQEAGIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITSCIFQLLQEAGIK 15 0 P22234;E9PBS1 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 283352000.0 191800000.0 23699000.0 67853000.0 False True 262713643.20010766 22651899.817887094 51827518.87640041 1.0 0.08622277679211832 0.19727760707472528 27.968915883308707 -10.314707935686291 5.506308635144237 1.000144605264326 0.14175019193353805 0.987598078381918 0.045337944610691704 8.049701952747762e-05 1.0018320056977855e-05 0.043905522136063566 0.014632758702364477 4.8449808443280956e-11 10.314707935686291 -0.8583944133307879 ITSCIFQLLQEAGIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITSCIFQLLQEAGIK 15 0 P22234;E9PBS1 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 1692550000.0 749270000.0 144190000.0 799090000.0 False True 623051203.2890719 143413219.8505259 966176024.425292 1.0 0.2301788666701084 1.5507168902409185 29.214775490078086 -6.748687649550519 1.65464706442886 0.5466123304541644 1.5530844246460984 0.6432680015551826 0.32346693237632046 0.30236997477907657 1.6283676958158662 0.15445311501948641 0.37549656848557855 1.783661139394051e-07 6.748687649550519 1.006472094191934 ITSCIFQLLQEAGIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITSCIFQLLQEAGIK 15 0 P22234;E9PBS1 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 1869570000.0 866040000.0 597280000.0 406250000.0 False True 1121105852.2005875 564040842.9486828 332316668.47700804 1.0 0.5031111396319471 0.2964186368528118 30.062275354462564 -13.111150368153377 0.13092316323080325 2.8888657505495257 1.6724707746949696e-22 0.9996661603824042 0.005394915056184493 8.687966842004554 0.10401161341458515 4.462558078827209 0.2493258893222669 7.741936980746744e-14 13.111150368153377 -2.8888657505495257 ITSDEPLTK(ub)DDIPVFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITSDEPLTKDDIPVFLR 17 1 Q9UBB4;Q9UBB4-2;A0A1W2PQD2;B1AHE4 Q9UBB4 ATXN10 Ataxin-10 1 442134700.0 154000700.0 201204200.0 86929800.0 True False 201896409.04490006 171185317.64782864 77935138.18552268 1.0 0.8478868864366897 0.3860154747387833 27.589040010039774 -6.951179417032227 0.5457418780174436 1.0065547722912849 0.2058074043684366 0.999290618951128 0.006953518970865185 0.08301557885277418 0.034028890963458416 0.007589164945285059 0.038286376209904195 1.118975513462929e-07 6.951179417032227 -0.8007473679228483 down ITSDEPLTK(ub)DDIPVFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITSDEPLTKDDIPVFLR 17 1 Q9UBB4;Q9UBB4-2;A0A1W2PQD2;B1AHE4 Q9UBB4 ATXN10 Ataxin-10 1 714462200.0 336735000.0 233025900.0 144701300.0 True False 326045531.7444203 326074357.0840153 106799688.58405003 1.0 1.000088408939208 0.3275606569813933 28.280498207711762 -6.9068618054274085 0.9168214101096246 1.0229457549577379 0.24623316997167338 0.9896827878036234 0.03220005282070917 0.10653086583511333 0.15028768373938087 0.025960145455156357 0.07019699176547638 1.2391908402276965e-07 6.9068618054274085 -0.7767125849860645 down ITSDEPLTK(ub)DDIPVFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITSDEPLTKDDIPVFLR 17 1 Q9UBB4;Q9UBB4-2;A0A1W2PQD2;B1AHE4 Q9UBB4 ATXN10 Ataxin-10 1 1127622000.0 474802000.0 376338000.0 276482000.0 True False 720309346.6757772 309177543.5577854 221835211.51363465 1.0 0.4292288375607476 0.30797214077174295 29.424041383803914 -13.99999999999988 0.21771862681790724 4.410233130930697 0.24167661437794868 0.9994957124033014 0.00677581997277688 12.938562054288846 0.14783498790110386 18.947697848016308 0.06813073467711105 1.0000000000002782e-14 13.99999999999988 -4.168556516552749 ITSDEPLTK(ub)DDIPVFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITSDEPLTKDDIPVFLR 17 1 Q9UBB4;Q9UBB4-2;A0A1W2PQD2;B1AHE4 Q9UBB4 ATXN10 Ataxin-10 1 457143500.0 154000700.0 198850400.0 104292400.0 True False 210938920.5024336 190064531.81766218 79660683.0894007 1.0 0.9010406015397685 0.3776481025865573 27.652250071562666 -6.938560534009212 0.6728267332795522 1.0060468852502473 0.24229073581714675 0.9979691427797606 0.012305444541309843 0.08842965836445894 0.05764757153952012 0.011851563209395387 0.04534054733938154 1.1519654822635543e-07 6.938560534009212 -0.7637561494331006 down ITSDEPLTK(ub)DDIPVFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITSDEPLTKDDIPVFLR 17 1 Q9UBB4;Q9UBB4-2;A0A1W2PQD2;B1AHE4 Q9UBB4 ATXN10 Ataxin-10 1 739801800.0 336735000.0 284490900.0 118575900.0 True False 280010072.38985425 282958291.05467784 143369572.45698357 1.0 1.0105289736174876 0.5120157686948206 28.06090348314604 -6.9020756929873395 0.9480461259670362 1.0195625065487304 0.4574242732112336 0.9875711641692185 0.025926812068608692 0.10989369555132429 0.16892549137811105 0.020427887619618505 0.05372571800010773 1.2529227845692338e-07 6.9020756929873395 -0.5621382333374968 ITSDEPLTK(ub)DDIPVFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITSDEPLTKDDIPVFLR 17 1 Q9UBB4;Q9UBB4-2;A0A1W2PQD2;B1AHE4 Q9UBB4 ATXN10 Ataxin-10 1 1076102000.0 474802000.0 421690000.0 179610000.0 True False 614640548.7466434 398222580.8046987 146922822.95422876 1.0 0.6478950691046047 0.23903861086586195 29.195167705896363 -7.400716493076779 0.3604493094289774 1.0492693064585201 6.298153100506303e-12 0.9995134999024531 0.0068585218327220955 0.11396646469790683 0.034053776750016196 0.01573320143525947 0.05874661719273815 3.974509202916015e-08 7.400716493076779 -1.049269306452222 down ITSEAEDLVANFFPKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITSEAEDLVANFFPKK 16 1 P61289;P61289-3;P61289-2;K9J957;K7ENH2;A0A087WTV2;B7Z8D3 P61289 PSME3 Proteasome activator complex subunit 3 1 14332400.0 5061000.0 7125400.0 2146000.0 True False 6635020.010793712 6062318.094591661 1923952.5058855705 1.0 0.9136849752871293 0.2899693599651131 22.66166938600168 -6.932039935854534 0.7298512927342236 1.008803718603368 0.15500699903981466 0.9969242356698225 0.01754384690014139 0.09159232410171254 0.07259142548725551 0.01618181069292032 0.05581591596528644 1.1693918538252355e-07 6.932039935854534 -0.8537967195635534 down ITSEALLVTQQLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITSEALLVTQQLVK 14 0 Q86VP6;H0YH27;Q86VP6-3 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 7631700.0 1109200.0 3435600.0 3086900.0 False True 1454171.941508078 2923021.871863908 2767497.1996356817 1.0 2.010093709298592 1.9031430332547838 20.471766433145074 -10.452265161169619 7.158138587352477 0.9998851907627934 1.956618371276688 0.9907125059086973 0.043662430658839194 8.000867245174553e-05 6.122238661887125e-06 0.04228088875987358 0.014091988899718352 3.5296759744950905e-11 10.452265161169619 0.9567331805138947 ITSEALLVTQQLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITSEALLVTQQLVK 14 0 Q86VP6;H0YH27;Q86VP6-3 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 3493900.0 1390300.0 640100.0 1463500.0 False True 1346165.6875117428 895695.268077402 1080165.4459411039 1.0 0.6653677748487321 0.8024015587098237 20.360424558648695 -10.249401776866986 5.036956621324191 1.0000440898375127 0.7338846667791329 0.8341164068048589 0.05594380799759322 2.7703382473734994e-05 4.128364498701704e-06 0.054176319026336815 0.01805578639143588 5.631164614225397e-11 10.249401776866986 -0.2661594230583798 ITSEALLVTQQLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITSEALLVTQQLVK 14 0 Q86VP6;H0YH27;Q86VP6-3 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 5817800.0 1109200.0 2022900.0 2685700.0 False True 1519301.2150029142 1933521.5891642617 2051392.9737277438 1.0 1.272638743437425 1.350221373793747 20.534976494667966 -13.062430075918275 0.1883695467829101 1.2176947541945216e-08 1.4091942481150213 0.9994627185960924 0.003481235846114164 8.456394889600107 0.1310095189007223 3.1783193794675335 0.05396641313282471 8.661037601650564e-14 13.062430075918275 1.4091942359380738 ITSGPFEPDLYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITSGPFEPDLYK 12 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 18837900.0 5968400.0 2798500.0 10071000.0 False True 5778936.408936981 3915955.643984712 7433102.97647615 1.0 0.6776256679220045 1.2862406592640543 22.462372563996986 -6.762789689784178 1.6018500451056465 0.8133966161890835 1.288784672794854 0.7022800736081145 0.1356519240418106 0.27826473848704975 1.4078100793810955 0.0667955392252109 0.16008884752878155 1.7266738437514378e-07 6.762789689784178 0.47538805660577044 ITSQIFIGPTYYQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITSQIFIGPTYYQR 14 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 23722600.0 8350400.0 8432800.0 6939400.0 False True 10947455.26538864 7174659.110796941 6221377.455425144 1.0 0.6553723159280923 0.5682943939578896 23.384092218726117 -13.999999999999998 0.19317426902227694 2.8681235882607337 0.5077804920532658 0.999487973798715 0.004217961697895223 12.40415091109572 0.13938027831021113 8.731979264932539 0.05840719766228386 1.0000000000000041e-14 13.999999999999998 -2.360343096207468 ITSQIFIGPTYYQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITSQIFIGPTYYQR 14 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 29812400.0 8365800.0 11805000.0 9641600.0 False True 12691530.221903492 9698305.517114013 7735933.533936606 1.0 0.7641557280757473 0.6095351308060283 23.597362690085443 -8.618070171383314 0.08483415762245175 1.6278278413821776 2.4617194823135643e-05 0.9999874173060632 0.0005694827286585697 0.2093273172051108 0.02204937748921246 0.21794410839136527 0.1909501451650991 2.4095160782719875e-09 8.618070171383314 -1.6278032241873546 ITSQIFIGPTYYQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITSQIFIGPTYYQR 14 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 26481200.0 8350400.0 7085800.0 11045000.0 False True 11437768.541074973 6772725.926392864 8436398.47891535 1.0 0.5921369978830096 0.7375912922716357 23.44730228024901 -10.183212605521827 5.577627949059605 1.000009321476177 0.6648641450772969 0.8762111943150739 0.05938146702487509 6.883306219974352e-06 1.0081697932745536e-06 0.057497456110363096 0.01916528607171229 6.558241340469875e-11 10.183212605521827 -0.3351451763988801 ITSQIFIGPTYYQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITSQIFIGPTYYQR 14 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 17409700.0 6967400.0 3942900.0 6499400.0 False True 5793701.808154983 3921658.8150956254 7858394.490169744 1.0 0.6768830956359637 1.3563684756969339 22.466054002816392 -6.777399266842886 1.5460702165182347 0.8164256504737533 1.361312500008254 0.7580624474624653 0.13649897903293434 0.25463355351053096 1.2020390716917488 0.06955146179689849 0.1644680927203212 1.669555010022299e-07 6.777399266842886 0.5448868495345007 ITSQIFIGPTYYQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITSQIFIGPTYYQR 14 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 38406800.0 8365800.0 16713000.0 13328000.0 False True 10829693.014571702 15782906.858092247 10902440.756828466 1.0 1.4573734303323127 1.0067174334636153 23.368489012177893 -10.607558711985956 3.0249500134007627 0.9849201586538754 1.2320454319369787 0.2611769677937198 0.18397954161900493 106985610.64252535 110975473.92423645 12746161.760661455 0.06571032683612017 2.4685463611851026e-11 10.607558711985956 0.2471252732831033 ITTFK(ub)DLVIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITTFKDLVIR 10 1 O75694;O75694-2 O75694 NUP155 Nuclear pore complex protein Nup155 1 7810600.0 1644800.0 1381900.0 4783900.0 True False 1592586.7243180003 1933699.876513299 3530853.076076283 1.0 1.2141881173481306 2.217055449578932 20.602940505910507 -6.941281294934779 0.6475439122936743 0.9889448581661439 2.497995448769247 0.9983268373720908 0.021699612451170885 0.08718712717709676 0.05198606361080871 0.021333807051560665 0.08583932351171947 1.1447712266183816e-07 6.941281294934779 1.509050590603103 up ITTFK(ub)DLVIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITTFKDLVIR 10 1 O75694;O75694-2 O75694 NUP155 Nuclear pore complex protein Nup155 1 15090100.0 1986200.0 3709400.0 9394500.0 True False 3013210.6106701917 3047428.58832552 7537672.957244378 1.0 1.0113559860482895 2.5015420198483453 21.52287008405887 -6.908570387355353 0.9054157729885797 0.9517489243672703 2.6883483919349267 0.9903707875466424 0.0691975359616296 0.10537097107693058 0.1439516267769098 0.056255509580574195 0.1537946168371302 1.2343252483165312e-07 6.908570387355353 1.7365994675676564 up ITTFK(ub)DLVIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITTFKDLVIR 10 1 O75694;O75694-2 O75694 NUP155 Nuclear pore complex protein Nup155 1 7283600.0 1644800.0 1626000.0 4012800.0 True False 1367724.0769947635 1617240.415264271 4851857.926909121 1.0 1.1824317802591866 3.547395274030624 20.383345781344783 -6.922310876153678 0.8074133210021803 0.9520363979485509 3.9497886300464438 0.9947989325015658 0.08367518291921146 0.09683099659473363 0.09871122939709258 0.07299137973967841 0.22371307583895214 1.195884188469247e-07 6.922310876153678 2.997752232097893 up ITTNQGVK(ub)GQSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITTNQGVKGQSK 12 1 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 1515920.0 0.0 847540.0 668380.0 True False 0.0 1185967.1418627105 493311.2270298013 0.0 ITTNQGVK(ub)GQSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITTNQGVKGQSK 12 1 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 1052970.0 0.0 624450.0 428520.0 True False 0.0 621085.963906379 518121.5507473821 0.0 ITTPYMTK(ub)YER ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITTPYMTKYER 11 1 U3KQS8;F8WC47;U3KPY1;U3KQB0;B0QYL8;B0QYL9;P61218 U3KQS8 POLR2F DNA-directed RNA polymerases I, II, and III subunit RPABC2 1 12635300.0 4327900.0 6081100.0 2226300.0 True False 5673918.811443214 5173823.583942146 1995943.8321775643 1.0 0.9118607008453361 0.35177518369704647 22.43591407644574 -6.934632692767039 0.7077360360479937 1.0072315456029626 0.22193937771206743 0.9973729110264421 0.014713583342003345 0.09030280423682441 0.06641309797643534 0.013795522734312914 0.0494510370430765 1.1624313316703021e-07 6.934632692767039 -0.7852921678908952 down ITTPYMTK(ub)YER ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITTPYMTKYER 11 1 U3KQS8;F8WC47;U3KPY1;U3KQB0;B0QYL8;B0QYL9;P61218 U3KQS8 POLR2F DNA-directed RNA polymerases I, II, and III subunit RPABC2 1 18663000.0 8383700.0 6243800.0 4035500.0 True False 8117564.03250537 8736981.900986865 2978481.4875950254 1.0 1.0763058801878427 0.36691813894762215 22.952615429065116 -6.880278180948757 1.0782972646963558 1.0474631159898842 0.3163854999474364 0.9739069490078941 0.05136001788671062 0.12738161442909107 0.2708272009212795 0.036683065836435325 0.08876828288169396 1.3174126189463692e-07 6.880278180948757 -0.7310776160424477 down ITTPYMTK(ub)YER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITTPYMTKYER 11 1 U3KQS8;F8WC47;U3KPY1;U3KQB0;B0QYL8;B0QYL9;P61218 U3KQS8 POLR2F DNA-directed RNA polymerases I, II, and III subunit RPABC2 1 11428900.0 4327900.0 4736200.0 2364800.0 True False 5928041.587099815 4526939.023481028 1806282.94458479 1.0 0.7636483241501263 0.30470146304565326 22.499124137968632 -6.960618333932782 0.42662984487063943 1.0188952738772474 0.03195218336973062 0.9997924489679887 0.004158650381445769 0.07948097938019476 0.020320614193468 0.005966303403566438 0.03813756907725543 1.0949181780380774e-07 6.960618333932782 -0.9869430905075168 down ITTPYMTK(ub)YER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITTPYMTKYER 11 1 U3KQS8;F8WC47;U3KPY1;U3KQB0;B0QYL8;B0QYL9;P61218 U3KQS8 POLR2F DNA-directed RNA polymerases I, II, and III subunit RPABC2 1 20107300.0 8383700.0 9946300.0 1777300.0 True False 6971418.010883396 9892717.307714025 2148925.2126932754 1.0 1.4190394683362921 0.30824793597780126 22.733020704499392 -6.804497174439029 1.4374496831138337 1.2299000758379388 0.2911508369388915 0.8449978306325393 0.18032066589362916 0.21439840202410573 0.8740622082684121 0.09866567239892213 0.2288641410565042 1.5685661028865006e-07 6.804497174439029 -0.9387492388990473 down ITTVIQHVFQNLILGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITTVIQHVFQNLILGSK 17 0 B3KVZ3;Q9H3R5;H0Y9E6 B3KVZ3 CENPH Centromere protein H 0 364915000.0 91785000.0 125600000.0 147530000.0 False True 88871335.4155689 175752734.9953474 108887467.19486904 1.0 1.977608800109897 1.2252259593681498 26.405214831047267 -10.17760396009359 4.692498736965152 0.9999168108778257 1.6014173797433275 0.46002793955388743 0.3071590085220142 0.00026736994067294285 4.685800720970416e-05 0.2974463243563714 0.09913514371817639 6.64348624117036e-11 10.17760396009359 0.6015005688655019 ITTVIQHVFQNLILGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITTVIQHVFQNLILGSK 17 0 B3KVZ3;Q9H3R5;H0Y9E6 B3KVZ3 CENPH Centromere protein H 0 557955300.0 192415300.0 161100000.0 204440000.0 False True 291908077.5426888 132350446.3199548 164032344.39076483 1.0 0.4533976840726506 0.5619315017645466 28.120938892068384 -9.992446520951821 6.159565133906422 1.0000003063160747 0.5076645929187428 0.9648340845457019 0.04430874553034043 1.863650199297911e-07 3.040978265261178e-08 0.042901785231731354 0.014300586127513486 1.0175446589756326e-10 9.992446520951821 -0.49233571339733195 ITTVIQHVFQNLILGSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITTVIQHVFQNLILGSK 17 0 B3KVZ3;Q9H3R5;H0Y9E6 B3KVZ3 CENPH Centromere protein H 0 338480000.0 91785000.0 69865000.0 176830000.0 False True 76323294.2649346 69488623.37788333 213804335.43045753 1.0 0.9104510496713277 2.8012985745648846 26.185620106481544 -6.895785357305483 0.9875414106469788 0.9120390711152134 2.983619481797777 0.9843498354447492 0.10896448056232429 0.11457399936694605 0.1954374283812493 0.08336776882131003 0.21266424385278046 1.271202220152391e-07 6.895785357305483 2.0715804106825635 up ITTVIQHVFQNLILGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITTVIQHVFQNLILGSK 17 0 B3KVZ3;Q9H3R5;H0Y9E6 B3KVZ3 CENPH Centromere protein H 0 439590200.0 192415300.0 141924900.0 105250000.0 False True 249085398.92260364 134026654.55298635 86095579.95619719 1.0 0.538075114529822 0.3456468356981013 27.892065214160834 -13.999999999999993 0.12009534124040964 3.2014493746584294 0.03891393131931892 0.999692474227539 0.0048152643908010145 11.963370515360266 0.10666552164095784 6.2850016544799905 0.2721920580506656 1.0000000000000164e-14 13.999999999999993 -3.1625354433391104 ITVAWCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITVAWCK 7 0 P11387 P11387 TOP1 DNA topoisomerase 1 0 23615700.0 7922800.0 5441900.0 10251000.0 False True 10386867.524504332 4629989.732360054 9190324.854535412 1.0 0.44575419118778065 0.884802355749115 23.30825729552326 -9.945173235205745 6.818773846746983 1.00000002148121 0.6652782734684518 0.4366086780177255 0.179240662613469 5.850763107905212e-08 8.91258991170013e-09 0.17354903695363316 0.05784967510542788 1.1345581628524918e-10 9.945173235205745 -0.3347217480127581 ITVAWCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITVAWCK 7 0 P11387 P11387 TOP1 DNA topoisomerase 1 0 6822700.0 3734400.0 1008000.0 2080300.0 False True 3615853.516107215 1410499.656650557 1535407.0223377352 1.0 0.3900876101222939 0.42463197568654165 21.78590480242398 -10.168813968786411 6.411895130294613 1.0000027753223213 0.407359792904417 0.9974582765750943 0.014102678186765864 5.594919062339168e-07 7.254395410718703e-08 0.013654923305998276 0.00455161981285513 6.779318393573323e-11 10.168813968786411 -0.5926429824179043 ITVAWCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITVAWCK 7 0 P11387 P11387 TOP1 DNA topoisomerase 1 0 20179200.0 7922800.0 5510300.0 6746100.0 False True 10852073.26561945 5266836.7258746475 5152810.120290705 1.0 0.4853300007253508 0.474822643947251 23.37146735704615 ITVAWCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITVAWCK 7 0 P11387 P11387 TOP1 DNA topoisomerase 1 0 7742400.0 3734400.0 1406700.0 2601300.0 False True 3105319.0619706046 1399121.8278919114 3145219.8029477405 1.0 0.4505565450669158 1.0128491598386078 21.566310077858255 -10.815316818381914 11.937976012268155 1.0016744518490701 0.7317028524527618 0.2328706219414275 0.22955499872099877 0.01027249696466144 0.00015891742982984761 0.22318038417011515 0.0740885572570911 1.5299709387157457e-11 10.815316818381914 -0.2699715993963083 ITVLQLSALLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITVLQLSALLK 11 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5;A0A0A0MSW0 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 0 22532500.0 3826500.0 7870000.0 10836000.0 False True 5805080.254621642 6465537.011409352 8694259.850412488 1.0 1.1137722008686952 1.4976984760013718 22.468884581659513 -6.948781360620472 0.5720755817886491 0.9952611976516862 1.6349420322203507 0.9991020752010773 0.006380486435912277 0.08397900001913698 0.03801771155824975 0.006743844801484624 0.03200501013394064 1.1251712828828614e-07 6.948781360620472 0.6396808345686645 ITVLQLSALLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITVLQLSALLK 11 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5;A0A0A0MSW0 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 0 11725300.0 3826500.0 3192800.0 4706000.0 False True 4953479.6815915555 3015117.8733032355 3849556.2876376575 1.0 0.608686835742602 0.7771418346467898 22.240010903751962 -10.201038532745772 5.409349977185542 1.0000146351557546 0.6929143351946515 0.8158677872117814 0.06877146532288218 1.2138685617812879e-05 1.793009787903066e-06 0.06659085598834416 0.02219589499079444 6.294503324454019e-11 10.201038532745772 -0.3071002999611031 ITVPGNFQGHSGAQCITCSYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITVPGNFQGHSGAQCITCSYK 21 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 102798000.0 24700000.0 33510000.0 44588000.0 False True 32381939.195140228 28510438.62095695 39974461.47829721 1.0 0.8804425963852004 1.234467807421998 24.94868604835236 -6.8155992150068405 1.3906536275723411 0.9352550175945429 1.2414989435231034 0.873968449194412 0.05220271867626372 0.1992815759975569 0.7584065822540369 0.02950563888572832 0.06810334075359954 1.5289764103337873e-07 6.8155992150068405 0.30624392592856053 ITVPGNFQGHSGAQCITCSYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITVPGNFQGHSGAQCITCSYK 21 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 54732000.0 24700000.0 13918000.0 16114000.0 False True 33832257.49240173 13303056.739328776 12308205.078247342 1.0 0.39320629852490524 0.36380088089042245 25.011896109875252 -13.645968577058568 0.4347468449393737 9.99922971347639 0.36334706289832663 0.9998768176199009 0.0032543949276018337 23.579703371280484 0.22166348602355807 200.3934917244809 0.006881556349512695 2.259599255343162e-14 13.645968577058568 -9.635882650578065 ITVPGNFQGHSGAQCITCSYK(ub)ASSGLLYPLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITVPGNFQGHSGAQCITCSYKASSGLLYPLER 32 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 30963600.0 6863000.0 5664600.0 18436000.0 True False 8884288.78995501 5349360.030416404 15080837.16933444 1.0 0.602114604431211 1.6974726425356113 23.082824858771918 -6.808424377807327 1.4211484681784818 0.7827472562520397 1.7159515313208278 0.8556679997946119 0.17199269345174256 0.20896073801902607 0.8320777592150826 0.09516958371190862 0.22030793862054784 1.5544459374901962e-07 6.808424377807327 0.9332042750687881 ITVTFNINNSIPPTFDGEEEPSQGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITVTFNINNSIPPTFDGEEEPSQGQK 26 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 74399200.0 30683200.0 21236000.0 22480000.0 False True 46548657.64239041 17446269.882374678 18036818.14666598 1.0 0.3747964123134435 0.3874830996252062 25.472236228545768 -10.000415066877972 5.453910144973835 1.0000020015226756 0.38113975596948946 0.9996849088224243 0.005179318410897248 1.3776221022492204e-07 2.5252174606165417e-08 0.005014871192125534 0.0016716178285580828 9.990447297555891e-11 10.000415066877972 -0.6188622455531861 ITVTFNINNSIPPTFDGEEEPSQGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITVTFNINNSIPPTFDGEEEPSQGQK 26 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 57348200.0 30683200.0 11870000.0 14795000.0 False True 39720007.256294295 11209424.065431412 12102461.809519583 1.0 0.282211027634067 0.30469435041711246 25.243362550638217 -10.091711259617378 5.173152902794485 1.000014004537754 0.29345268904052546 0.9992411250267099 0.009178778094813203 1.4968440010165293e-06 2.628172908201397e-07 0.00888749126952763 0.0029624378909690117 8.096340048809856e-11 10.091711259617378 -0.7065613154972284 ITVTSEVPFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITVTSEVPFSK 11 0 P35268;K7ERI7;K7EMH1;K7ELC4;K7EP65;K7EKS7;K7EJT5 P35268 RPL22 60S ribosomal protein L22 0 138897000.0 45381000.0 37874000.0 55642000.0 False True 59494930.47022916 32223346.831695735 49884699.59575252 1.0 0.5416150010935817 0.8384697519852464 25.826263406631227 -10.119637488081583 5.207548220220037 1.0000080681151935 0.6900423765390826 0.5924414194058512 0.1211904445687571 1.1352388254254888e-05 1.9193565475196253e-06 0.11734519700195271 0.03911404779435559 7.592110351026942e-11 10.119637488081583 -0.30996569157611087 ITVTSEVPFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITVTSEVPFSK 11 0 P35268;K7ERI7;K7EMH1;K7ELC4;K7EP65;K7EKS7;K7EJT5 P35268 RPL22 60S ribosomal protein L22 0 82207000.0 26575000.0 11140000.0 44492000.0 False True 25731391.17141954 15588260.09433254 32838210.468610577 1.0 0.6058071244763007 1.2761925793225184 24.61702612290982 -6.74734791703359 1.6594855884602049 0.7674709684327976 1.2772721030839207 0.637507260911771 0.16562645386907845 0.3047169350853358 1.6501660972155083 0.07886750297220185 0.1920182477673667 1.7891719587605124e-07 6.74734791703359 0.5098011346511231 ITVTSEVPFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITVTSEVPFSK 11 0 P35268;K7ERI7;K7EMH1;K7ELC4;K7EP65;K7EKS7;K7EJT5 P35268 RPL22 60S ribosomal protein L22 0 139043000.0 45381000.0 29234000.0 64428000.0 False True 62159582.07541232 27942345.21608974 49211433.33631127 1.0 0.44952595051539995 0.7916950483452047 25.88947346815412 -10.391186368130567 6.441328222444824 1.0000454482200105 0.6206104994303133 0.6210950461792271 0.1396899492385801 9.118243428993809e-05 8.618187859221857e-06 0.13527035321871678 0.04508473725279836 4.0626895017563685e-11 10.391186368130567 -0.3794349487896972 ITVTSEVPFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITVTSEVPFSK 11 0 P35268;K7ERI7;K7EMH1;K7ELC4;K7EP65;K7EKS7;K7EJT5 P35268 RPL22 60S ribosomal protein L22 0 48984900.0 26575000.0 13029000.0 9380900.0 False True 22098289.972115662 12958810.190945975 11342402.817619069 1.0 0.5864168769301978 0.5132706119763693 24.397431398344096 -13.999999999999998 0.2436836193739851 3.7872068156368477 0.4820404828044853 0.9995312289696973 0.004639755606537408 13.756323491810727 0.15622228676807495 18.69813060309656 0.03498440190585328 1.0000000000000041e-14 13.999999999999998 -3.3051663328323624 ITVVGVGQVGMACAISILGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITVVGVGQVGMACAISILGK 20 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 17394700.0 10182000.0 2249100.0 4963600.0 False True 9858777.983345013 3147177.3589015547 3663484.2551918398 1.0 0.31922590854751554 0.37159618173578607 23.23297740186781 -10.321111151079197 8.804643265415889 1.0000006895956943 0.34541104514165083 0.9952223563803457 0.021380074500236927 2.894005542864483e-07 2.2317397638120233e-08 0.020701190017434933 0.00690038937334096 4.774070729283111e-11 10.321111151079197 -0.6545896444540436 ITVVGVGQVGMACAISILGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITVVGVGQVGMACAISILGK 20 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 37063500.0 15424000.0 12603000.0 9036500.0 False True 23399335.645442083 10353896.182311561 7250431.81416135 1.0 0.4424867585643774 0.30985631062451335 24.479964233565845 -13.999999999999995 0.2017100595886402 4.119501701772471 0.22515696076730998 0.9994870829866005 0.006772076926951789 12.565232105167267 0.1424016564212117 15.475748789308973 0.08338788812167813 1.0000000000000123e-14 13.999999999999995 -3.894344741005161 ITVVGVGQVGMACAISILGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITVVGVGQVGMACAISILGK 20 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 22500900.0 10182000.0 1855900.0 10463000.0 False True 8466784.139081152 1845901.8983326938 12650764.92455396 1.0 0.2180168843341999 1.4941641025380943 23.013382677302086 -6.740862102293356 1.6833417289897925 0.5352014606135423 1.4950898905005956 0.6089335494930156 0.3285499864588977 0.3162354036360323 1.75978439530742 0.15437806632356987 0.37850102875069536 1.816092219021246e-07 6.740862102293356 0.9598884298870533 ITVVGVGQVGMACAISILGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITVVGVGQVGMACAISILGK 20 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 32622500.0 15424000.0 11444000.0 5754500.0 False True 19966672.05249395 10807131.339915512 4707240.046156164 1.0 0.5412585187708154 0.23575486359371559 24.251090555658294 -8.284443533746442 0.2571614908924354 1.199433355077897 2.5379059245984463e-19 0.999395305348431 0.007723527884882491 0.09760425602884554 0.0593355195456291 0.09985640347309076 0.104074462389327 5.194652091277722e-09 8.284443533746442 -1.199433355077897 down ITWSIIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 ITWSIIR 7 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 56001000.0 16493000.0 12857000.0 26651000.0 False True 21622482.718439195 10938785.716193486 23893410.174443822 1.0 0.5058986915903566 1.105026212094878 24.366028848705874 -6.687587936817705 1.874556054176713 0.6895474319305528 1.102925228872988 0.35941520666991666 0.2090710101532436 0.4218378741020646 2.87192763969394 0.08927798213075096 0.23323235559292219 2.0531092666846522e-07 6.687587936817705 0.41337779694243526 ITWSIIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 ITWSIIR 7 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 48733400.0 15385000.0 6561400.0 26787000.0 False True 14896611.59632322 9181401.237248972 19770681.107225377 1.0 0.6163415873389037 1.3271931660019365 23.828480874824898 -6.76013973742598 1.6121217967745902 0.7771835586235485 1.3297908150882827 0.6914486569978704 0.1613701693499789 0.2826940149743415 1.4480927393886571 0.07897952252714276 0.18976060183541213 1.7372417685681316e-07 6.76013973742598 0.5526072564647342 ITWSIIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 ITWSIIR 7 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 15712500.0 5295700.0 4799900.0 5616900.0 False True 8033964.067529032 3943320.343210125 4506717.253025276 1.0 0.49083121483551184 0.5609581042613979 22.937680578166653 -10.55245096080133 6.3390742538037435 1.00068996689836 0.5258946595485907 0.9838559587773981 0.02862918272366634 0.0002795453109429272 1.973636692539316e-05 0.02775760179379153 0.009240028992024077 2.8025220559817498e-11 10.55245096080133 -0.47479530734976927 ITWSIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITWSIIR 7 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 47633000.0 16493000.0 12642000.0 18498000.0 False True 22590907.806566074 12083434.638496509 14129153.378268545 1.0 0.5348804369421775 0.62543539636605 24.429238910228765 -9.885652439880097 5.454476317148544 1.0000003506740214 0.580157916651611 0.9662853081701434 0.03696890738670759 1.5765870893193868e-07 3.217258300558229e-08 0.03579502052414859 0.011931663551729484 1.3012105029843212e-10 9.885652439880097 -0.4198424340224104 ITWSIIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 ITWSIIR 7 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 33383400.0 15385000.0 8391500.0 9606900.0 False True 12793309.171063006 8346293.323917666 11615658.372713136 1.0 0.652395186602386 0.9079479138193908 23.608886150259174 -9.828545808913015 6.39829149929132 1.0000000070271382 0.7801715502108384 0.49662992406918527 0.10432896400989937 1.0490881548251281e-08 1.999703363503725e-09 0.10101608879741551 0.033672028344758034 1.4840693337776717e-10 9.828545808913015 -0.2198284568162998 ITWSIIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITWSIIR 7 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 22725000.0 5295700.0 9550000.0 7879300.0 False True 6855388.043853237 9018534.10487532 6445348.248445268 1.0 1.3155395503776959 0.9401872231323762 22.708806900259102 -6.68373931465328 1.8885726426812772 1.1989613546578206 0.941566845239055 0.34149506489247394 0.13362317337462018 0.4301747406233906 2.969546132000755 0.05670717630750699 0.14885030494481458 2.0713843245467492e-07 6.68373931465328 -0.2573945094187656 ITYLQNPKDCSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 ITYLQNPKDCSK 12 1 G3XAD2;A0A669KAW1;Q9BYC5-2;Q9BYC5-3;Q9BYC5 G3XAD2 FUT8 Alpha-(1,6)-fucosyltransferase 0 33465200.0 9189300.0 17221000.0 7054900.0 False True 11895729.998183541 16262636.211524379 5770980.58938694 1.0 1.3670986323670475 0.48513042833589526 23.503940471699185 -6.793659337909698 1.4817192543374833 1.2041980629660138 0.4747861631588981 0.8129578098296824 0.15644783545240834 0.22993558570949932 0.9971722207537149 0.08309230745548297 0.19403059648864815 1.6082022377728396e-07 6.793659337909698 -0.7294118998071157 down ITYVANVNPGGWAPASVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 ITYVANVNPGGWAPASVLR 19 0 A0A2R8YFA1;A0A2R8YE59;A0A2U3TZL3;A0A2R8Y7Q9;A0A2R8YEK8;Q9Y5P4-2;Q9Y5P4;Q9Y5P4-3;A0A2R8Y5H3;A0A2R8Y5S9 A0A2R8YFA1 COL4A3BP Collagen type IV alpha-3-binding protein 0 2615700.0 0.0 1313800.0 1301900.0 False True 0.0 1255751.971844383 994418.0334721496 0.0 IVACDGK(ub)NTGSNTTE ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVACDGKNTGSNTTE 15 1 A0A0B4J1Z5;P52657 A0A0B4J1Z5 GTF2A2 Transcription initiation factor IIA subunit 2 1 8528000.0 1367400.0 1660300.0 5500300.0 True False 1323992.6354769177 2323266.448350121 4059606.4245369695 1.0 1.7547427274874932 3.0661850494921006 20.336463666703082 -6.962699452771201 0.3955595736541223 0.9242810084228057 3.944190384083592 0.9998575793344803 0.010187603133448502 0.07875061549031646 0.017669219421363663 0.016890927102168576 0.1100649025150858 1.0896839325016019e-07 6.962699452771201 3.019909375660786 IVACDGK(ub)NTGSNTTE ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVACDGKNTGSNTTE 15 1 A0A0B4J1Z5;P52657 A0A0B4J1Z5 GTF2A2 Transcription initiation factor IIA subunit 2 1 97598400.0 2565400.0 12986000.0 82047000.0 True False 3891899.3558621104 10668546.83991891 65830374.48752246 1.0 2.7412185836331004 16.914716560788378 21.892042971972483 -6.929774025986709 0.7486418622894396 0.7826491897367852 19.807815725822138 0.9964936993840445 0.4220418548549577 0.09275529503367629 0.07825545424442074 0.3839851358443952 1.2840540572623238 1.1755090418702825e-07 6.929774025986709 19.025166536085354 IVACDGK(ub)NTGSNTTE ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVACDGKNTGSNTTE 15 1 A0A0B4J1Z5;P52657 A0A0B4J1Z5 GTF2A2 Transcription initiation factor IIA subunit 2 1 14234100.0 1367400.0 1214700.0 11652000.0 True False 1137053.6860910994 1208156.1700009278 14088379.327239119 1.0 1.0625322135441648 12.390249906028073 20.11686894213736 -6.90810976158505 0.9084944183825636 0.6279604741216774 13.796565851529683 0.9901888787451671 0.530392629550385 0.10568174466416075 0.14563940109093634 0.43022124506583365 1.1726367954919652 1.2356351052583493e-07 6.90810976158505 13.168605377408007 up IVACDGK(ub)NTGSNTTE ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVACDGKNTGSNTTE 15 1 A0A0B4J1Z5;P52657 A0A0B4J1Z5 GTF2A2 Transcription initiation factor IIA subunit 2 1 73730400.0 2565400.0 11326000.0 59839000.0 True False 3320960.8715941412 10695698.14364585 48948915.99998937 1.0 3.2206637046318636 14.739383537660505 21.663169294064932 -6.938989237591804 0.6689005172769897 0.8681724479225392 17.755383282340333 0.9980284946803347 0.26738770242116366 0.0882307837014807 0.05673228236645541 0.25833027959553573 0.9958894551000224 1.1508289076973057e-07 6.938989237591804 16.887210834417793 IVADKDYSVTANSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVADKDYSVTANSK 14 1 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 59860950.0 6558750.0 28869600.0 24432600.0 False True 8598584.765025359 24562368.212819383 21904548.926048394 1.0 2.856559408790912 2.547459788399701 23.035667796523132 -10.384030488632197 5.793160811850031 0.9995402184564203 2.702009598595309 0.9758608435216977 0.12618939160775164 0.0007495361592248432 7.96954785061632e-05 0.12221071108755358 0.04072745101373741 4.1301850597049464e-11 10.384030488632197 1.702469380138889 IVADKDYSVTANSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVADKDYSVTANSK 14 1 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 57494200.0 13475700.0 6433600.0 37584900.0 False True 13047921.279725235 9002570.030780785 27740287.167168986 1.0 0.6899620129353173 2.1260311564167518 23.63731664738159 -6.850200231434678 1.2341891963473 0.8345336766979968 2.183642976910423 0.9405938139425808 0.150387364655513 0.15723064771621792 0.46078308740231244 0.09534666175305725 0.22065753926097675 1.411886444411941e-07 6.850200231434678 1.3491093002124264 up IVADKDYSVTANSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVADKDYSVTANSK 14 1 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 217397200.0 3426500.0 207832000.0 6138700.0 False True 5198251.010704578 170742755.80117247 4925383.254312204 1.0 32.84619296943681 0.9475077760134194 22.309594868997184 -3.1108096614502543 15.183502240446412 9.999999999998373 15.852040090742031 0.0 15.10955711530616 0.0 0.0 4.937998312957568 0.0 0.0007748012961130406 3.1108096614502543 5.8520400907436585 IVADKDYSVTANSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVADKDYSVTANSK 14 1 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 61337550.0 6558750.0 25969800.0 28809000.0 False True 8983697.118554259 24822368.36535565 22004907.539979387 1.0 2.7630459974089487 2.4494266947771526 23.098877858046023 -10.413479285614876 5.735834879115775 0.9993055782006337 2.6062363460930515 0.9722025665478445 0.12803454415590912 0.0011373651789614982 0.0001163016438501544 0.1240119695846665 0.04132297143792313 3.8594081923388803e-11 10.413479285614876 1.6069307678924178 IVADKDYSVTANSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVADKDYSVTANSK 14 1 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 15659500.0 13475700.0 0.0 2183800.0 False True 11205641.624731472 0.0 2640422.483249635 1.0 0.0 0.23563331504570664 23.417721922815865 -10.873915696909728 10.771366440172631 1.038677520248355 0.11781665752946228 0.9492098848523011 0.09619689804374258 0.04857253366333951 0.0005685650796369745 0.05063430460907642 0.031047415340018997 1.3368549950207231e-11 10.873915696909728 -0.9208608627188927 IVADKDYSVTANSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVADKDYSVTANSK 14 1 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 16869900.0 3426500.0 8660700.0 4782700.0 False True 4435671.7964127725 8178724.431632844 3912297.674646124 1.0 1.8438524775992584 0.8820079244388837 22.080721191089633 -6.674970023579138 1.9195790413422764 1.5363167980652224 0.885789272009729 0.3012294790306236 0.35804683048714 0.44986197152947455 3.2002820549741613 0.1499053966042266 0.3979576596930034 2.1136349247744362e-07 6.674970023579138 -0.6505275260554934 IVADKDYSVTANSK(ub)IVVVTAGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVADKDYSVTANSKIVVVTAGVR 23 2 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 1 14265100.0 2892900.0 3618400.0 7753800.0 True False 2801066.4729933967 5063245.989706729 5722847.170986074 1.0 1.8076136494882336 2.0430958087439737 21.417544790194643 -10.7439772590336 0.2494632703043103 4.158801343376619e-12 2.1615725407581703 0.9991961451420235 0.012664536843833198 2.5266342522626246 0.1282816288687327 1.6205652528893262 0.10768135860663601 1.803112154767864e-11 10.7439772590336 2.1615725407540114 IVADKDYSVTANSK(ub)IVVVTAGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVADKDYSVTANSKIVVVTAGVR 23 2 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 1 11107600.0 2892900.0 4399300.0 3815400.0 True False 2405574.5271997494 4375600.097707323 4613182.499583597 1.0 1.8189418154509707 1.9177050835143536 21.19795006562892 -11.085704779397917 0.38078622923887684 7.377464209531615e-11 1.9284023336936826 0.9994913690288141 0.009276268938189464 2.9812033082025153 0.188831144001686 2.6053493954406006 0.026644222189557608 8.20909384736716e-12 11.085704779397917 1.928402333619908 IVADQLCAK(ub)YSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVADQLCAKYSK 12 1 P53990-2;P53990;P53990-4;H3BQF7;H3BMU1;H3BUI0;P53990-3;P53990-5;J3KR23 P53990-2 IST1 IST1 homolog 1 33091600.0 3598900.0 8192700.0 21300000.0 True False 5459794.414832833 6730648.675142738 17090045.66387837 1.0 1.2327659548603747 3.1301628532842165 22.38041519770645 -6.9297483926537655 0.7488559515905623 0.9708751985198418 3.5172026124928415 0.9964885267631983 0.05653474629285264 0.09276876154133101 0.0783221779032574 0.051428917065004624 0.17191997415352595 1.1755784259061548e-07 6.9297483926537655 2.5463274139729997 up IVADQLCAK(ub)YSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVADQLCAKYSK 12 1 P53990-2;P53990;P53990-4;H3BQF7;H3BMU1;H3BUI0;P53990-3;P53990-5;J3KR23 P53990-2 IST1 IST1 homolog 1 17284200.0 3598900.0 6328900.0 7356400.0 True False 4658846.994924829 5976691.151449783 6017610.683038189 1.0 1.282869164400669 1.2916523529520383 22.1515415197989 -12.006843369758817 0.5325023950274707 4.062828748801192e-13 1.2909840783221387 0.999928972196249 0.0011416444938025748 6.90322897510607 0.2639171823323347 7.8594285706234235 0.0016887453077424326 9.843660577572625e-13 12.006843369758817 1.2909840783217323 IVAERPGTNSTGPAPMAPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVAERPGTNSTGPAPMAPPR 20 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 11372900.0 2558700.0 1236400.0 7577800.0 False True 2477475.469061572 1730100.967740823 5592946.850872899 1.0 0.6983322294594334 2.257518558999665 21.24043934183647 -6.856545145391119 1.2030837988948948 0.8376053285848134 2.328182151432004 0.949297301586525 0.15204326296326895 0.1504057346415401 0.4156544540767375 0.09869763250164015 0.22956414045289678 1.3914091488087633e-07 6.856545145391119 1.4905768228471903 up IVAK(ub)AVYDNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVAKAVYDNR 10 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 13819800.0 1820700.0 7196300.0 4802800.0 True False 2762135.0109995073 5912064.040051466 3853524.4748579785 1.0 2.140396474650283 1.3951253141183495 21.397352408449116 -10.184201804465085 4.820312226620274 0.9999278463385183 1.7677608943783918 0.585924475538627 0.3042556773971979 0.00029334604146188383 4.964582704628722e-05 0.2946284126255341 0.09819809760229938 6.543320536613481e-11 10.184201804465085 0.7678330480398735 IVAK(ub)AVYDNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVAKAVYDNR 10 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 9792760.0 1820700.0 5000360.0 2971700.0 True False 2356932.0413625343 4722085.570330292 2430881.0922169234 1.0 2.0034882158080682 1.0313751307023853 21.168478730541565 -6.63876776844343 2.048678586034412 1.6568400647214472 1.0353961070853954 0.1499104983774392 0.42949649017177016 0.5365448887457082 4.302300555685868 0.1708043730876233 0.47566013674591845 2.2973768027224504e-07 6.63876776844343 -0.6214439576360518 IVALNAHTFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVALNAHTFLR 11 0 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;A6NHQ2 P22087;A6NHQ2 FBL;FBLL1 rRNA 2-O-methyltransferase fibrillarin;rRNA/tRNA 2-O-methyltransferase fibrillarin-like protein 1 0 64308300.0 27289000.0 37019300.0 0.0 False True 35776143.267051876 31496164.740101207 0.0 1.0 0.8803678055791909 0.0 25.092494534849067 -7.139619999431659 0.9481041194719388 0.9952543679231468 3.2428112113197005e-20 0.9896975717317498 0.045258204779155195 0.08700236417626273 0.1481257923960375 0.037768201027791194 0.06639356136732369 7.250701070848473e-08 7.139619999431659 -0.9952543679231468 down IVALNAHTFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVALNAHTFLR 11 0 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;A6NHQ2 P22087;A6NHQ2 FBL;FBLL1 rRNA 2-O-methyltransferase fibrillarin;rRNA/tRNA 2-O-methyltransferase fibrillarin-like protein 1 0 84945800.0 53006400.0 17770400.0 14169000.0 False True 51323740.846236385 24866213.391411763 10457713.839111377 1.0 0.48449729075497083 0.2037597740671752 25.613122992543 -8.875522863000409 0.2440265077477605 1.3022810194977685 3.247717880036325e-21 0.9992616901070647 0.008959641652286372 0.37579802553032343 0.07753167292518612 0.21191909696069486 0.11584880718645443 1.3319169230277774e-09 8.875522863000409 -1.3022810194977685 IVALNAHTFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVALNAHTFLR 11 0 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;A6NHQ2 P22087;A6NHQ2 FBL;FBLL1 rRNA 2-O-methyltransferase fibrillarin;rRNA/tRNA 2-O-methyltransferase fibrillarin-like protein 1 0 276994300.0 59954200.0 94031000.0 123009100.0 False True 90954904.63913141 77250433.3824438 98696297.46819629 1.0 0.8493267481169833 1.0851124286236051 26.438648099864757 -6.734095591947794 1.7082634676394746 0.9097409209843791 1.0850810032302298 0.5781359821938192 0.0633218024718223 0.3286256768402666 1.8805076932621683 0.029352927402595274 0.07250294046503314 1.8446093601198327e-07 6.734095591947794 0.17534008224585074 IVALNAHTFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVALNAHTFLR 11 0 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;A6NHQ2 P22087;A6NHQ2 FBL;FBLL1 rRNA 2-O-methyltransferase fibrillarin;rRNA/tRNA 2-O-methyltransferase fibrillarin-like protein 1 0 89903500.0 27289000.0 25643000.0 36971500.0 False True 37378480.75749597 24510007.469938736 28239593.15194375 1.0 0.6557250849480671 0.755504038143137 25.155704596371958 -10.29019380753052 8.090298576552037 1.0000005325646004 0.7056145615456025 0.9206745324723926 0.04073458706616109 3.9132063512774926e-07 3.4324791428203015e-08 0.039441165734404905 0.013147031443489826 5.126325663859514e-11 10.29019380753052 -0.2943859710189979 IVALNAHTFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVALNAHTFLR 11 0 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;A6NHQ2 P22087;A6NHQ2 FBL;FBLL1 rRNA 2-O-methyltransferase fibrillarin;rRNA/tRNA 2-O-methyltransferase fibrillarin-like protein 1 0 88887700.0 53006400.0 19706300.0 16175000.0 False True 44077170.18167266 19600138.25050569 19557117.715249952 1.0 0.4446777814846074 0.44370175387034766 25.393528267977278 IVALNAHTFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVALNAHTFLR 11 0 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;A6NHQ2 P22087;A6NHQ2 FBL;FBLL1 rRNA 2-O-methyltransferase fibrillarin;rRNA/tRNA 2-O-methyltransferase fibrillarin-like protein 1 0 281860200.0 59954200.0 113295700.0 108610300.0 False True 77611893.77396472 106990694.7000756 88844339.8357869 1.0 1.3785347773071108 1.1447258340910391 26.209774421957206 -10.14501618024866 4.082402251297478 0.9999265078971937 1.2616303055409575 0.6254013403479652 0.09545210176492701 13192663.153076338 10965106.387765551 8663.413577493957 0.03267579282347937 7.161167297850189e-11 10.14501618024866 0.2617037976437637 IVALSSSLSNAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVALSSSLSNAK 12 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 13098400.0 4163800.0 4913700.0 4020900.0 False True 5458782.122296552 4180595.1134525845 3604855.839196314 1.0 0.765847586474797 0.6603773073250491 22.38014768491827 -13.999999999939554 0.10767590751958611 2.1347448025828766 0.4602578861817673 0.9997548755546688 0.0022220989409260333 12.026817112929129 0.0991861163121311 2.980280145602028 0.17786624784890853 1.0000000001391817e-14 13.999999999939554 -1.6744869164011094 IVALSSSLSNAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVALSSSLSNAK 12 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 8489900.0 1539600.0 2027100.0 4923200.0 False True 1490726.2407344338 2836531.6011868515 3633666.2271658643 1.0 1.902785047769322 2.437514097407765 20.50758391252747 -8.911065496216201 0.1658115148431407 8.432877417543422e-20 3.2270160824916663 0.9997855565885564 0.008687336616929048 0.4081079284022682 0.052409044220370286 0.5619437590025765 0.3537914663330375 1.2272541342555412e-09 8.911065496216201 3.2270160824916663 IVALSSSLSNAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVALSSSLSNAK 12 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 26505300.0 3618800.0 19428000.0 3458500.0 False True 5489984.169717703 15960921.608343177 2774925.9590856032 1.0 2.907280078580608 0.5054524518288895 22.388370558572372 -6.695105632935189 1.847892066365153 2.19000060438725 0.5131358240814805 0.3944355973693773 0.8058359880413302 0.405874113279487 2.6907863747547855 0.3483246344063703 0.9013948669498802 2.0178754985074704e-07 6.695105632935189 -1.6768647803057695 IVALSSSLSNAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVALSSSLSNAK 12 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 15634100.0 4163800.0 3448600.0 8021700.0 False True 5703269.382464059 3296229.4490048317 6127139.672097342 1.0 0.5779543675667513 1.0743205802160714 22.443357746441162 -6.6814734674530705 1.8969571740244096 0.7333187202226081 1.0724408889597028 0.330794092096215 0.17881573156916014 0.43522903968651516 3.0293364706957804 0.07560920504895349 0.19901630849096927 2.0822196113078947e-07 6.6814734674530705 0.33912216873709466 IVAPELYIAVGISGAIQHLAGMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVAPELYIAVGISGAIQHLAGMK 23 0 P13804;P13804-2;H0YLU7;H0YNX6;H0YK49;H0YM12;H0YL83 P13804 ETFA Electron transfer flavoprotein subunit alpha, mitochondrial 0 1512950000.0 429170000.0 600370000.0 483410000.0 False True 651082266.5297196 493229282.7877799 387863801.6138698 1.0 0.7575529363081889 0.5957216492490126 29.27826460358962 -8.257459535211941 0.09223330420702383 1.5577487419696692 0.0012067268253823996 0.9999890960156386 0.0005485707580034799 0.08527588023440066 0.018817253182753242 0.15143432153631228 0.1528166892048504 5.527649086514622e-09 8.257459535211941 -1.5565420151442868 IVAPELYIAVGISGAIQHLAGMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVAPELYIAVGISGAIQHLAGMK 23 0 P13804;P13804-2;H0YLU7;H0YNX6;H0YK49;H0YM12;H0YL83 P13804 ETFA Electron transfer flavoprotein subunit alpha, mitochondrial 0 927940000.0 429170000.0 137660000.0 361110000.0 False True 555569025.2054487 129999099.98713456 295391685.301495 1.0 0.23399270673713504 0.531692142470073 29.04939092568207 -10.455921031878038 6.083916503437952 1.0003021795365967 0.38284242460933554 0.8514174796085598 0.12153528571002888 0.0004983762079372051 4.456913298556891e-05 0.11773152821693975 0.03922534479429179 3.500088036305635e-11 10.455921031878038 -0.6174597549272611 IVAPGK(ub)GILAADESTGSIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVAPGKGILAADESTGSIAK 20 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 178689200.0 18422000.0 34772000.0 125495200.0 True False 24151420.398901742 29584153.14019438 112510160.53896144 1.0 1.2249446472117096 4.658531824657307 24.525604703880923 -6.920213975693371 0.8231445570030672 0.9248229647885424 5.214951480674032 0.9942400232504282 0.1270587246609625 0.09804599862821411 0.10496512596846536 0.10959823406673287 0.32897017596386907 1.201672228147767e-07 6.920213975693371 4.29012851588549 up IVAPGK(ub)GILAADESTGSIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVAPGKGILAADESTGSIAK 20 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 533696000.0 38462000.0 63131000.0 432103000.0 True False 37241044.86303439 88339537.52381574 318922261.4878638 1.0 2.3721014769782123 8.563730224562718 25.15039021502369 -6.942116766727397 0.6395671188005911 0.9322384273476636 10.342803832433997 0.9984282285458229 0.13044199756815036 0.08681406743577769 0.05031056470876676 0.12911311786240354 0.5281309767231088 1.1425710957386833e-07 6.942116766727397 9.410565405086334 IVAPGK(ub)GILAADESTGSIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVAPGKGILAADESTGSIAK 20 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 1483622200.0 58681200.0 343021000.0 1081920000.0 True False 89023670.57036549 281806222.51469445 868078037.777619 1.0 3.1655201443525187 9.751092402907366 26.407685650561046 -6.951144293038825 0.5461366079268318 0.906767426117576 12.31718276897953 0.9992880511118188 0.09929636883287248 0.08302947791018495 0.034085711001227585 0.10831698130070042 0.5459426227964645 1.1190660153678855e-07 6.951144293038825 11.410415342861954 IVAPGK(ub)GILAADESTGSIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVAPGKGILAADESTGSIAK 20 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 157090100.0 18422000.0 36786000.0 101882100.0 True False 25233111.235830944 35160672.88496535 77819646.30771397 1.0 1.3934339113536385 3.0840289800335956 24.588814765403814 -6.9432322862606215 0.6287731789660645 0.9815578521872312 3.5868276655740035 0.9985573679651661 0.03433837262444063 0.08632248284718956 0.048123304622072115 0.03430970605157737 0.14356347898096838 1.1396400779045643e-07 6.9432322862606215 2.605269813386772 up IVAPGK(ub)GILAADESTGSIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVAPGKGILAADESTGSIAK 20 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 251356600.0 38462000.0 87028600.0 125866000.0 True False 31982857.155503783 86559759.65797552 152183998.66136962 1.0 2.7064423680821728 4.758299045061425 24.930795490457967 -6.968671360782991 0.2881616795942046 0.5901629395007307 6.9378100405882135 0.9999700833019775 0.008403940783164652 0.07673624556801162 0.010565735336809925 0.036205316150926745 0.18647089356449684 1.0748024289278683e-07 6.968671360782991 6.347647101087483 IVAPGK(ub)GILAADESTGSIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVAPGKGILAADESTGSIAK 20 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 720626200.0 58681200.0 343814000.0 318131000.0 True False 75963970.17938335 324680448.66320384 260234422.29971457 1.0 4.27413743510897 3.4257612087044693 26.178811972653495 -9.781314937214564 7.244435409016628 0.999999995771839 3.8499493219067595 0.9376811871635635 0.3463481440999654 2.3500614043181355e-08 4.138713106535871e-09 0.3353501510207401 0.11178338284072947 1.6545696844587028e-10 9.781314937214564 2.8499493261349205 IVATK(ub)PLYVALAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVATKPLYVALAQR 14 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YB86 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 24878600.0 5422100.0 4433500.0 15023000.0 True False 8225722.108606813 3642307.2859063977 12053697.46518518 1.0 0.44279483768304617 1.4653664816336363 22.971710903099396 -6.7587479596443805 1.6172487275004175 0.6758353618029118 1.468862749782428 0.6857882757820171 0.23432162674625354 0.28503749099880143 1.4690589323219583 0.11433561419736644 0.27510007733226877 1.7428180145733584e-07 6.7587479596443805 0.7930273879795162 IVATKPLYVALAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVATKPLYVALAQR 14 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YB86 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 137284000.0 43567000.0 70286000.0 23431000.0 False True 57116758.9034282 59799602.7726822 21006584.886022773 1.0 1.046971220369666 0.3677832091547817 25.76741078001734 -6.89031953856617 1.0204598993534502 1.0362143866994227 0.30899299733564317 0.9811030966534098 0.042572578934678446 0.11888549671543344 0.22032144140466914 0.031773521147250676 0.07930590294001214 1.28730205170912e-07 6.89031953856617 -0.7272213893637796 down IVATKPLYVALAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVATKPLYVALAQR 14 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YB86 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 121183000.0 58899000.0 33673000.0 28611000.0 False True 57029283.48468254 47118804.50237527 21116920.7883983 1.0 0.8262212257152219 0.37028206384655143 25.765199571027715 -6.954419445168239 0.5080234868639827 1.0085294708701633 0.16803865789749375 0.9995039740915806 0.005914105320074397 0.08175832039986583 0.02898351166717747 0.006835363852864888 0.03762497950737635 1.1106585260091055e-07 6.954419445168239 -0.8404908129726696 down IVATKPLYVALAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVATKPLYVALAQR 14 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YB86 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 228735000.0 79791000.0 73342000.0 75602000.0 False True 121048780.50346674 60253547.0763385 60659231.56246628 1.0 0.49776252867423876 0.5011139419180605 26.851013304189873 -10.229950008407991 5.50046675155573 1.00002909523728 0.4994382371848361 0.9999663802087587 0.001368208727539852 4.882051234751443e-07 6.834733005633683e-08 0.00132483923066437 0.00044158746797577896 5.889114409879778e-11 10.229950008407991 -0.5005908580524439 IVATKPLYVALAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVATKPLYVALAQR 14 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YB86 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 161487000.0 43567000.0 56647000.0 61273000.0 False True 59674897.253905594 54144148.23342124 46801579.35704659 1.0 0.9073186670610919 0.7842758263648879 25.83062084154023 -6.967207734498612 0.31790834736854745 1.0172696915998598 0.6703684145293378 0.9999516708279252 0.0006142395114559353 0.07721975104080153 0.012260101946498465 0.001881156065754918 0.010843351679432796 1.0784307569814878e-07 6.967207734498612 -0.346901277070522 IVATKPLYVALAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVATKPLYVALAQR 14 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YB86 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 120500000.0 58899000.0 33551000.0 28050000.0 False True 48977128.16811437 33370254.10364789 33915125.311453596 1.0 0.6813436261330847 0.6924686395461911 25.54560484646199 -10.084520361408053 5.1531712018236355 1.0000059986161955 0.6869061328389734 0.9990539744139413 0.004541767709604075 3.130110689590039e-07 5.5609913501579124e-08 0.00439763192236411 0.001465849224803731 8.23151243496976e-11 10.084520361408053 -0.31309986577722215 IVATKPLYVALAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVATKPLYVALAQR 14 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YB86 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 207757000.0 79791000.0 72813000.0 55153000.0 False True 103291022.41575117 68760892.54222885 45115719.91756908 1.0 0.6657005704277285 0.4367825863507886 26.622139626282323 -8.103818349755873 0.1529070966286289 1.3604175376711 3.800318304950876e-08 0.9999361598835041 0.0018478406137792038 0.09245060134127678 0.02831923220983552 0.10524730596865987 0.11979009426906316 7.873750523706197e-09 8.103818349755873 -1.360417499667917 down IVAVTGAEAQK(ub)ALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVAVTGAEAQKALR 14 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 10665100.0 2088700.0 3299500.0 5276900.0 True False 2022395.361796574 4617007.556665196 3894721.5863933098 1.0 2.2829401431002716 1.9257963403028546 20.947633629248923 -10.106514949734489 4.779051644359916 0.999968325236781 2.1043682416607004 0.9272680883120351 0.14580334785311236 9.213523860889848e-05 1.722525368692081e-05 0.14118100385413127 0.04705782803444145 7.825012685338324e-11 10.106514949734489 1.1043999164239193 IVAVTGAEAQK(ub)ALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVAVTGAEAQKALR 14 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 7774200.0 2088700.0 3223200.0 2462300.0 True False 1736846.5950990762 3205835.981844895 2977155.5456111305 1.0 1.8457795817379152 1.7141154285081248 20.7280389046832 -10.369727482294625 5.584184541799626 0.9997642198051097 1.7799475051230254 0.9790742396713541 0.05375166547145263 0.0001578293810950033 1.781376179397411e-05 0.0520600752264302 0.01734827543348464 4.268472794050689e-11 10.369727482294625 0.7801832853179157 IVDGK(ub)VVSETNDTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVDGKVVSETNDTK 14 1 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 11518300.0 1689500.0 2403000.0 7425800.0 True False 2214950.861141271 2044481.7668206342 6657449.449303394 1.0 0.9230370762117941 3.005687198800018 21.07884326215676 -6.898316820350031 0.9718281692151444 0.9093668844835833 3.2169895653773897 0.9857107149266535 0.11525146490218836 0.11265554296170675 0.18448114211033964 0.08921745117468324 0.2302338152736605 1.2638140514021292e-07 6.898316820350031 2.3076226808938065 up IVDGK(ub)VVSETNDTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVDGKVVSETNDTK 14 1 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 36555990.0 2679400.0 7607090.0 26269500.0 True False 2594343.9136294117 10644640.707450299 19388729.881892588 1.0 4.103018359103653 7.473461702603768 21.30693830936091 -6.970067601009141 0.2565661075793521 0.013178374391683526 11.662852514597125 0.9999829053717005 0.010929850476559168 0.07628076991675 0.00895161212831606 0.0719504631008008 0.31967274527157846 1.0713525286560753e-07 6.970067601009141 11.649674140205441 IVDGK(ub)VVSETNDTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVDGKVVSETNDTK 14 1 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 81929100.0 3587500.0 7679900.0 70661700.0 True False 5442499.781381194 6309361.841667419 56695384.02287671 1.0 1.159276452936528 10.417158713874784 22.375838013786296 -6.910634034523575 0.8914106622209775 0.7190739279351087 11.62993430160913 0.9911585373045532 0.4139374802254164 0.1040001187660702 0.13650579772407673 0.3399621359963798 0.9426178157179961 1.2284739891809094e-07 6.910634034523575 10.910860373674021 up IVDGK(ub)VVSETNDTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVDGKVVSETNDTK 14 1 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 11045200.0 1689500.0 2611300.0 6744400.0 True False 2314153.807020757 2495924.1315856576 5151511.625278105 1.0 1.078547209789358 2.226088693694117 21.14205332367965 -6.920750607166389 0.8191440554573781 0.9753590426425846 2.4143710685607007 0.9943868489199738 0.04198482607676333 0.09773202974890144 0.10334151509462439 0.036318764659925735 0.10958440352784182 1.2001883113021885e-07 6.920750607166389 1.439012025918116 up IVDGK(ub)VVSETNDTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVDGKVVSETNDTK 14 1 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 24602890.0 2679400.0 9787370.0 12136120.0 True False 2228039.817546069 9734643.495169153 14673726.580921136 1.0 4.3691514929435815 6.585935522948852 21.087343584795185 -8.234831836185597 0.2966013903232949 3.1011664861827148e-24 7.919276073315927 0.9989421724669564 0.07469415065652008 0.09812816009816575 0.0711221511663091 0.6011489236207999 0.682702818545875 5.823286584702517e-09 8.234831836185597 7.919276073315927 IVDGK(ub)VVSETNDTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVDGKVVSETNDTK 14 1 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 51227830.0 3587500.0 10268430.0 37371900.0 True False 4644089.470197231 9696982.843824591 30570597.668076012 1.0 2.0880267070765046 6.582689214809142 22.146964335878746 -6.944134593328615 0.6199053303553024 0.950804307536783 7.957992487402945 0.9986568471417732 0.08855986896001379 0.08592999358620254 0.04639305246676723 0.08919423196789575 0.38037125463591964 1.1372747754289815e-07 6.944134593328615 7.007188179866161 IVDQIRPDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVDQIRPDR 9 1 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 11410100.0 2643200.0 1434800.0 7332100.0 False True 2559293.062814533 2007723.1223831533 5411603.051714909 1.0 0.7844834777050499 2.114491353234711 21.287313928136076 -6.865365585367886 1.1584122681605324 0.8809506682612791 2.18579315009909 0.9598303807752504 0.11681750984581525 0.14137135924385713 0.35750068514031785 0.07846623351615595 0.1844068775281294 1.3634349255598695e-07 6.865365585367886 1.3048424818378108 up IVDVIGEKIYK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVDVIGEKIYK 11 1 P13861-2;P13861;H7C4A9 P13861-2 PRKAR2A cAMP-dependent protein kinase type II-alpha regulatory subunit 1 3402480.0 685780.0 1171800.0 1544900.0 True False 664010.2892769933 1639705.8508562725 1140244.3439934463 1.0 2.469398256827713 1.7172088481264347 19.340846071692567 -10.278831187142613 5.429535938994648 0.999867221190091 2.0933035524771277 0.7380047889635304 0.30708004020750984 0.0004936241896902296 6.55648789109335e-05 0.29736425013415946 0.09910965680633842 5.262217721856468e-11 10.278831187142613 1.0934363312870368 IVEGILK(ub)RPPDEQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVEGILKRPPDEQR 14 2 B8ZZU8;Q15370;Q15370-2;I3L0M9;A0A0B4J296 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 23600400.0 6799600.0 6399600.0 10401200.0 True False 8914341.447420059 5444804.625445418 9324983.599355549 1.0 0.6107915719361664 1.04606533801264 23.087696791107742 -6.6709961966276 1.9345588004044467 0.7517781444459518 1.0442881620414048 0.28327143627539575 0.1652899706997545 0.45876332042202483 3.311242664229806 0.06877317949840876 0.1834583680407909 2.1330635935581696e-07 6.6709961966276 0.29251001759545303 IVEGILK(ub)RPPDEQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVEGILKRPPDEQR 14 2 B8ZZU8;Q15370;Q15370-2;I3L0M9;A0A0B4J296 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 36039800.0 4881500.0 7827100.0 23331200.0 True False 4726539.454498009 10952501.847787287 17220058.799003106 1.0 2.317234829673186 3.6432698731871676 22.172352867259356 -6.971042663769071 0.23193709822623776 0.47360710929260513 5.524874789303696 0.9999894116292162 0.003511402925892657 0.07596582541807372 0.007809089220753101 0.033590820201568436 0.13121133237764798 1.068949863680957e-07 6.971042663769071 5.05126768001109 IVEGILK(ub)RPPDEQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVEGILKRPPDEQR 14 2 B8ZZU8;Q15370;Q15370-2;I3L0M9;A0A0B4J296 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 142904900.0 16387700.0 26395200.0 100122000.0 True False 24861339.001349308 21684770.333361123 80332842.8149685 1.0 0.8722285767546236 3.231235566620469 24.567400664487053 -6.894102500743304 0.9978250146967564 0.8854298814979735 3.451199450206532 0.9833959505895741 0.13957593622870423 0.11587659612522154 0.20292172227215519 0.10596786311106035 0.26838799432854565 1.2761375835054277e-07 6.894102500743304 2.5657695687085584 up IVEGILK(ub)RPPDEQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVEGILKRPPDEQR 14 2 B8ZZU8;Q15370;Q15370-2;I3L0M9;A0A0B4J296 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 20307400.0 6799600.0 3404900.0 10102900.0 True False 9313595.872280758 3254460.2595014046 7716803.095756788 1.0 0.3494311224290256 0.8285524948235767 23.150906852630634 -9.883178861506135 6.386236332988329 1.0000000303086607 0.5889918086264022 0.4952502569189179 0.19560048120493326 8.437942586273424e-08 1.502483347499035e-08 0.1893893656647143 0.06312978385138204 1.3086428555053757e-10 9.883178861506135 -0.4110082216822585 IVEGILK(ub)RPPDEQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVEGILKRPPDEQR 14 2 B8ZZU8;Q15370;Q15370-2;I3L0M9;A0A0B4J296 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 29836950.0 4881500.0 11558250.0 13397200.0 True False 4059183.53711694 11495983.413117005 16198492.578346029 1.0 2.832092539792398 3.9905789995027194 21.952758142693632 -8.392501354931095 0.2316009171379106 1.1903410370084069e-19 5.066989944438126 0.9995266443871805 0.026786438418351998 0.12365150647538625 0.05757893051600126 0.5097617165194094 0.46972259449245224 4.0504068147072445e-09 8.392501354931095 5.066989944438126 IVEGILK(ub)RPPDEQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVEGILKRPPDEQR 14 2 B8ZZU8;Q15370;Q15370-2;I3L0M9;A0A0B4J296 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 142748500.0 16387700.0 25193800.0 101167000.0 True False 21214200.69986096 23791742.88286993 82755644.06107926 1.0 1.1215007918269513 3.9009550834324696 24.338526986579502 -6.916063070205939 0.8534091025054356 0.9295463175076891 4.3109583224529855 0.9930155961665614 0.11197108564313354 0.10054452914838549 0.11802550949475882 0.0945142143524223 0.27328615705851445 1.2132126494511027e-07 6.916063070205939 3.3814120049452963 up IVEPYIAWGYPNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVEPYIAWGYPNLK 14 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 87136000.0 19700000.0 33046000.0 34390000.0 False True 25826890.775071405 28115665.612299107 30831652.692173727 1.0 1.088619836478221 1.1937810463012841 24.622370636224062 -6.968858683529755 0.2841297455716239 0.9779547047677396 1.30766886681397 0.9999720544096604 0.00041867574748188116 0.07667485086258506 0.010349670902306617 0.0018973951633860435 0.009603180560950662 1.0743389380540708e-07 6.968858683529755 0.3297141620462304 IVEPYIAWGYPNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVEPYIAWGYPNLK 14 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 87785000.0 35616000.0 17430000.0 34739000.0 False True 34485389.57521272 24389889.896249216 25639813.752338927 1.0 0.7072528452391355 0.7434978716542677 25.03948192894595 -10.237539079817294 8.181062807736069 1.0000001588542704 0.7253753585626805 0.9871043795195314 0.014796970071795309 4.287524255617016e-08 3.99264552383787e-09 0.014327112991601854 0.004775701555199395 5.787099110234755e-11 10.237539079817294 -0.27462480029158987 IVEPYIAWGYPNLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVEPYIAWGYPNLK 14 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 70143000.0 13953000.0 42855000.0 13335000.0 False True 21167721.10093709 35207190.42235669 10699331.40506186 1.0 1.663248974911998 0.5054550442176887 24.335362622581652 -6.751333521141097 1.6448086294470476 1.3893715444202954 0.5029049036148598 0.6547203910192947 0.2787228091728912 0.29772992728631636 1.5851586045567676 0.13383735107399747 0.32448015391304474 1.7728274959458947e-07 6.751333521141097 -0.8864666408054356 IVEPYIAWGYPNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVEPYIAWGYPNLK 14 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 81496000.0 19700000.0 29456000.0 32340000.0 False True 26983622.372482397 28154536.52203392 24701958.063207094 1.0 1.043393512308622 0.9154426237597322 24.685580697746953 -6.81518836824607 1.3924461503884573 1.023508725365841 0.9129247290247421 0.8729844835668382 0.01893482904948287 0.199807291455665 0.76247132775037 0.01068894918944267 0.024674823870001975 1.5304235211196418e-07 6.81518836824607 -0.11058399634109894 IVEPYIAWGYPNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVEPYIAWGYPNLK 14 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 60259000.0 35616000.0 13149000.0 11494000.0 False True 29616282.05632629 13078163.727127843 13897342.257748568 1.0 0.44158695214527227 0.4692466877279749 24.819887204380226 -10.677977758754206 6.664917198675637 1.0038887734946293 0.455416819936627 0.9980689677346343 0.01129203976632083 0.0006548252597300307 3.1638503895203095e-05 0.010972404464788072 0.003644490163306036 2.099047378043089e-11 10.677977758754206 -0.5484719535580023 IVEPYIAWGYPNLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVEPYIAWGYPNLK 14 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 61205000.0 13953000.0 29942000.0 17310000.0 False True 18062433.554748982 28275701.378866665 14159757.615598794 1.0 1.5654425132228325 0.7839341012759549 24.1064889446741 -6.7125781243642475 1.7857055098778685 1.3466918528486862 0.7856004543509735 0.47750284096831586 0.23817966883117056 0.36990463735578094 2.300781942421079 0.10607374825432496 0.26866926020367043 1.938303926978805e-07 6.7125781243642475 -0.5610913984977127 IVEPYVTWGFPNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVEPYVTWGFPNLK 14 0 Q6DKI1;R4GMU7 Q6DKI1 RPL7L1 60S ribosomal protein L7-like 1 0 4152840.0 813540.0 1699800.0 1639500.0 False True 1066558.818332568 1446196.4657685065 1469860.2671945004 1.0 1.355946283421532 1.3781333405432286 20.02453209860025 -11.971834122524413 0.4341179753439498 3.9220287908475935e-11 1.3785928504210512 0.9998039543873184 0.0024259315085935393 5.7526823854889 0.21806741151484957 5.2768526520131775 0.005196020148749768 1.0670035822309934e-12 11.971834122524413 1.378592850381831 IVETIEELK(ub)VK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVETIEELKVK 11 1 A6NHB5;Q14202-2;Q14202;A6NHN7 A6NHB5 ZMYM3 Zinc finger MYM-type protein 3 1 15688300.0 2882600.0 5163000.0 7642700.0 True False 3779116.515138109 4392700.5252163755 6851906.717955105 1.0 1.162361760379818 1.8130975032149015 21.849617568795455 -6.9448299160275635 0.6129932316649612 0.9928305440432242 2.016691010394249 0.9987304466207201 0.012518452244352387 0.08563080702389049 0.045084745579008226 0.012688933216986857 0.05492997737294471 1.1354554102114318e-07 6.9448299160275635 1.0238604663510245 IVETIEELK(ub)VK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVETIEELKVK 11 1 A6NHB5;Q14202-2;Q14202;A6NHN7 A6NHB5 ZMYM3 Zinc finger MYM-type protein 3 1 23071840.0 4776800.0 5639040.0 12656000.0 True False 4625163.098688127 7890738.079205124 9341013.928138437 1.0 1.7060453676635186 2.0196074665535377 22.141072810092524 -10.292368157993579 0.18071276555660787 1.3544979423154864e-15 2.346094583046865 0.9995181354435918 0.009360275425951557 1.9492314135549413 0.08937328492592932 1.1195917346719098 0.2194042950154117 5.1007242055223945e-11 10.292368157993579 2.3460945830468636 IVETIEELK(ub)VK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVETIEELKVK 11 1 A6NHB5;Q14202-2;Q14202;A6NHN7 A6NHB5 ZMYM3 Zinc finger MYM-type protein 3 1 48092400.0 8457600.0 13461000.0 26173800.0 True False 12830797.53338247 11058779.378726974 21000536.95761592 1.0 0.8618933741222901 1.6367288863360103 23.613107512090092 -6.8608195874595355 1.1814737282947276 0.9248916456958177 1.674862082960842 0.9546361866210742 0.07187325531651094 0.1459660710543434 0.386683484527924 0.047428543189998236 0.11082492558589678 1.3777817015259234e-07 6.8608195874595355 0.7499704372650243 IVETIEELK(ub)VK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVETIEELKVK 11 1 A6NHB5;Q14202-2;Q14202;A6NHN7 A6NHB5 ZMYM3 Zinc finger MYM-type protein 3 1 16469900.0 2882600.0 4094200.0 9493100.0 True False 3948375.119335923 3913304.7062911256 7251025.29653158 1.0 0.9911177606015571 1.8364580561309813 21.912827630318347 -6.904526983687703 0.9322135480607493 0.9690839822461249 1.93381779055889 0.9886866790226451 0.04216488210591424 0.10814948064944939 0.15922716153513097 0.0336126918953941 0.08961714186912158 1.2458708261243958e-07 6.904526983687703 0.9647338083127651 IVETIEELK(ub)VK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVETIEELKVK 11 1 A6NHB5;Q14202-2;Q14202;A6NHN7 A6NHB5 ZMYM3 Zinc finger MYM-type protein 3 1 17692800.0 4776800.0 5377400.0 7538600.0 True False 3972120.848120496 5348430.878869674 9114886.405451829 1.0 1.3464924868538206 2.294715280318008 21.9214780855268 -6.953496050009154 0.5190459568026383 0.9837676071192245 2.6996872023589864 0.9994478509844738 0.012859503408297933 0.08211154031170464 0.030382014144236517 0.014590395064243354 0.07831646675044926 1.1130225159070569e-07 6.953496050009154 1.715919595239762 up IVETIEELK(ub)VK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVETIEELKVK 11 1 A6NHB5;Q14202-2;Q14202;A6NHN7 A6NHB5 ZMYM3 Zinc finger MYM-type protein 3 1 45474500.0 8457600.0 13602000.0 23414900.0 True False 10948529.924220243 12845036.742881032 19153628.457162593 1.0 1.1732202251614943 1.7494246798185298 23.38423383418254 -6.949108409816333 0.568546182839214 0.9927745774078852 1.9578151828411257 0.9991294564678148 0.009452106552589599 0.08384571646471499 0.03745913844592141 0.01003061259914207 0.047992184686219075 1.1243242819290695e-07 6.949108409816333 0.9650406054332404 IVEVLLMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVEVLLMK 8 0 P38159;P38159-2;H3BT71;H0Y6E7;H3BR27;P38159-3;O75526 P38159 RBMX;RBMXL2 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA-binding motif protein, X-linked-like-2 0 17717600.0 5042300.0 5576100.0 7099200.0 False True 6610504.129702653 4744167.615467557 6364642.884334971 1.0 0.717671076575056 0.9628074893315677 22.6563288679389 -10.178821452941996 6.996005785546659 1.000000287408914 0.8402392832685148 0.36156148589034953 0.10007652143828982 4.4861372505099996e-07 5.2629535792142767e-08 0.09689884992963027 0.0322995584064055 6.624888099858681e-11 10.178821452941996 -0.15976100414039918 IVEVLLMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVEVLLMK 8 0 P38159;P38159-2;H3BT71;H0Y6E7;H3BR27;P38159-3;O75526 P38159 RBMX;RBMXL2 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA-binding motif protein, X-linked-like-2 0 15774600.0 6849700.0 3460000.0 5464900.0 False True 6632260.022836217 4841596.043661631 4033478.7465142035 1.0 0.7300069700209331 0.6081605263705159 22.6610691392312 -13.999999999830862 0.10736534335490674 2.30925732747637 0.37591458283825113 0.9997564553193597 0.0025552211402006964 12.02881469677739 0.09898953232758136 3.4314153104392777 0.20644180374984827 1.0000000003894537e-14 13.999999999830862 -1.933342744638119 IVEVLLMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVEVLLMK 8 0 P38159;P38159-2;H3BT71;H0Y6E7;H3BR27;P38159-3;O75526 P38159 RBMX;RBMXL2 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA-binding motif protein, X-linked-like-2 0 29759400.0 5006600.0 17863000.0 6889800.0 False True 7595378.231487972 14675208.085743977 5528028.010093383 1.0 1.9321234095894435 0.7278147106849759 22.856690378568345 -6.700072656552834 1.830904773624492 1.5787707092151753 0.7314237237546434 0.4178493736798876 0.3934548002501032 0.3953383508272288 2.5766145330403187 0.1714486817233571 0.44083303496195175 1.9949285397034156e-07 6.700072656552834 -0.8473469854605319 IVEVLLMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVEVLLMK 8 0 P38159;P38159-2;H3BT71;H0Y6E7;H3BR27;P38159-3;O75526 P38159 RBMX;RBMXL2 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA-binding motif protein, X-linked-like-2 0 27090200.0 5042300.0 9353900.0 12694000.0 False True 6906574.5730338935 8940613.768789152 9695938.641136372 1.0 1.2945076715303971 1.403870839097764 22.71953892946179 -12.826868934253584 0.1514428820407743 1.3147024032519116e-10 1.5294473979903134 0.999571133193377 0.0035320739032984215 7.731124392086738 0.11220951701759574 2.4244774370152147 0.10595741183450161 1.4898106198713065e-13 12.826868934253584 1.5294473978588432 IVEVLLMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVEVLLMK 8 0 P38159;P38159-2;H3BT71;H0Y6E7;H3BR27;P38159-3;O75526 P38159 RBMX;RBMXL2 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA-binding motif protein, X-linked-like-2 0 13545800.0 6849700.0 2151900.0 4544200.0 False True 5695829.043160891 2140307.287581291 5494371.209993134 1.0 0.37576747324451487 0.9646306390797225 22.441474414665475 -10.79526006554974 10.210686404204973 1.0026774207762454 0.6701990561621202 0.2948950627425997 0.24040238076936177 0.01471320614076236 0.0002950216254127797 0.23373258087169832 0.07758953475902935 1.602285617778165e-11 10.79526006554974 -0.3324783646141253 IVEVLLMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVEVLLMK 8 0 P38159;P38159-2;H3BT71;H0Y6E7;H3BR27;P38159-3;O75526 P38159 RBMX;RBMXL2 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA-binding motif protein, X-linked-like-2 0 17563100.0 5006600.0 8664400.0 3892100.0 False True 6481142.39484027 8182218.523380286 3183777.736318435 1.0 1.2624654767490167 0.4912371218464643 22.627816700660794 -6.814852088859995 1.393854527992582 1.1422457467141087 0.4761687402064872 0.8721685379456792 0.11446843517538369 0.20025229481721996 0.7657900080846911 0.06455462171745827 0.1490406793084625 1.5316090051742912e-07 6.814852088859995 -0.6660770065076216 down IVFAAGNFWGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVFAAGNFWGR 11 0 P04181;P04181-2 P04181 OAT Ornithine aminotransferase, mitochondrial;Ornithine aminotransferase, hepatic form;Ornithine aminotransferase, renal form 0 12251100.0 1750200.0 4217000.0 6283900.0 False True 2397296.2373765837 4030678.99624583 4799772.240982897 1.0 1.6813437294077158 2.0021606700702943 21.192976765247824 -10.1850977884346 0.17015028933229276 1.0948652049627236e-18 2.3796594669994517 0.9995940736747942 0.008418922554320649 1.808606227958294 0.08250175192539803 1.0383301836811722 0.2420187927130888 6.529835062837553e-11 10.1850977884346 2.3796594669994517 IVFSGNLFQHQEDSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVFSGNLFQHQEDSK 15 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 0 17276000.0 5013900.0 5940500.0 6321600.0 False True 6573271.454676674 5054200.555887633 5667501.47306907 1.0 0.768901846019417 0.8622040808974689 22.648180134204488 -10.10543317507379 5.394202896681728 1.000002756745698 0.8155529634866214 0.8389881532729448 0.03809047788575337 1.2628500260620388e-06 2.0942346992369675e-07 0.03688149753059923 0.012293648875002531 7.844528134124037e-11 10.10543317507379 -0.1844497932590765 IVFSGNLFQHQEDSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVFSGNLFQHQEDSK 15 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 0 10753300.0 4126500.0 2236500.0 4390300.0 False True 3995506.5162318987 3129546.1131934216 3240348.7238231795 1.0 0.7832664270423588 0.8109982328045614 21.929946976641357 -9.923474549016419 6.614889540580224 1.0000000153502573 0.7971323299899324 0.9861787402547761 0.011321462293910744 2.5596169634782494e-09 4.074456566002437e-10 0.010961959628152934 0.0036539862432503176 1.1926841587436583e-10 9.923474549016419 -0.20286768536032485 IVFSGNLFQHQEDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVFSGNLFQHQEDSK 15 0 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 0 15544900.0 5013900.0 4602700.0 5928300.0 False True 6867674.325552763 4399337.494906485 4528157.63717101 1.0 0.6405862139585939 0.6593436762606748 22.71139019572738 -10.209914712186887 4.851036663767419 1.0000514490489762 0.6499649451088588 0.9978509216034553 0.007657701920985845 4.2616445993349555e-06 6.940849079055559e-07 0.007415625316098946 0.0024715126671291565 6.167161021874104e-11 10.209914712186887 -0.3500865039401174 IVFSGNLFQHQEDSKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVFSGNLFQHQEDSKK 16 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 0 11795700.0 4663200.0 3748800.0 3383700.0 False True 6113500.358493033 3189493.6527079465 3033587.1827423163 1.0 0.5217131701443379 0.49621117279039306 22.543567218412097 -13.995673077967831 0.4176802201280793 9.99999913100119 0.49529627099737106 0.9998612262487592 0.0027296075779456833 29.43383406239047 0.21509517404830986 241.56102714090267 0.0062272250401533965 1.0100129031522383e-14 13.995673077967831 -9.504702860003817 IVFSGNLFQHQEDSKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVFSGNLFQHQEDSKK 16 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 0 12624800.0 4663200.0 3667000.0 4294600.0 False True 6387311.058241609 3504979.81485261 3280303.930063358 1.0 0.548741055961272 0.5135657086608848 22.606777279934988 -13.999999999999998 0.3618146511969267 6.971558529832163 0.509439687263108 0.999776558482007 0.0033107057624838917 21.893936376505618 0.1945441448960351 101.03687124469262 0.010090474604523815 1.0000000000000041e-14 13.999999999999998 -6.462118842569055 IVFSGNLFQHQEDSKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVFSGNLFQHQEDSKK 16 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 0 10820600.0 6359400.0 1921100.0 2540100.0 False True 5288122.869188042 1910750.6529915067 3071223.165904572 1.0 0.3613287172513997 0.5807775730400414 22.33432426748387 -10.145417677852734 5.539039740290885 1.0000097689208565 0.4710531451456404 0.8856663722234098 0.08958962022024614 1.0808085828730142e-05 1.6674285823985612e-06 0.08674637823470638 0.02891492559213075 7.15454998400049e-11 10.145417677852734 -0.5289566237752161 IVFVPGCSIPLTIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVFVPGCSIPLTIVK 15 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 10943700.0 2829900.0 5456900.0 2656900.0 False True 3710026.3047905862 4642751.790829602 2381989.4747844287 1.0 1.2514067042690857 0.6420411283091646 21.82299798518815 -6.794672105165672 1.4776475194923921 1.1396616665340837 0.6347024779930966 0.8161043893361414 0.10722347418328002 0.22845202775020435 0.9852465212206803 0.05710233334110173 0.13324823597322222 1.604456307257816e-07 6.794672105165672 -0.5049591885409871 IVFVPGCSIPLTIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVFVPGCSIPLTIVK 15 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 15833000.0 2829900.0 5458300.0 7544800.0 False True 3876190.505171976 5217134.257815655 5762873.630033534 1.0 1.3459437173829476 1.486736429064611 21.88620804671104 -12.212784107218916 0.14586913788836198 5.372914445710626e-18 1.6662552845574048 0.9996129728764689 0.004023284336396551 5.992934926117023 0.10242055757281557 1.9419217231396813 0.14313914306697972 6.126548738206734e-13 12.212784107218916 1.6662552845574048 IVFVTGNAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVFVTGNAK 9 0 Q9BY32;Q9BY32-3 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 0 13762400.0 3036700.0 5270800.0 5454900.0 False True 3981143.1074446295 4484417.185417482 4890479.27509563 1.0 1.1264144654915176 1.2284108214925926 21.92475130126333 -6.9735626618360875 0.15043490245553517 0.8821521662156437 1.4753567178322373 0.9999985222940377 0.00011342239125763393 0.07516275419741153 0.004600113117260441 0.005182895311962232 0.012701404734149515 1.0627652319713044e-07 6.9735626618360875 0.5932045516165936 IVFVTGNAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVFVTGNAK 9 0 Q9BY32;Q9BY32-3 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 0 9523600.0 3036700.0 2889900.0 3597000.0 False True 4159450.0537318354 2762214.6623786604 2747462.682540381 1.0 0.6640816999113661 0.6605350820537856 21.987961362786223 IVGHLTHALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVGHLTHALK 10 0 P24752;A0A5F9ZHL1;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 10317300.0 2175100.0 5861300.0 2280900.0 False True 3299785.721110031 4815305.220454077 1830079.115246014 1.0 1.4592781554416308 0.5546054410558467 21.653940912241016 -6.768698549768357 1.5795059921811043 1.263867715243266 0.5497737648890426 0.7255354923369153 0.1934977899016579 0.2685375907866064 1.3219998866680198 0.09657456483311298 0.23015653238839587 1.7033404119649514e-07 6.768698549768357 -0.7140939503542234 IVGNLLYYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVGNLLYYR 9 0 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 0 7543000.0 0.0 3537500.0 4005500.0 False True 0.0 3381201.553051838 3059483.395861962 0.0 IVGNLLYYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVGNLLYYR 9 0 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 0 9165000.0 4685900.0 0.0 4479100.0 False True 6065989.92289817 0.0 3663949.759447056 1.0 0.0 0.6040151411422915 22.532311670616803 -10.105203228928632 6.695828033411125 1.0000007119433014 0.3020075705711453 0.6403537972309157 0.24658814878563173 2.620485713032897e-06 3.501546962238971e-07 0.23875819030393317 0.07958598280157203 7.848682680633452e-11 10.105203228928632 -0.6979931413721561 IVGPQVVIFCMHHQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVGPQVVIFCMHHQR 15 0 A0A2R8YD63;Q92547 A0A2R8YD63 TOPBP1 DNA topoisomerase 2-binding protein 1 0 3910700.0 1388300.0 1310700.0 1211700.0 False True 1901592.0273968165 1252788.940094714 925521.4157448362 1.0 0.6588105766354726 0.4867087169122329 20.858776329095374 -13.999999999999952 0.08841572430774426 2.759459763279509 0.04416155092557791 0.999849779585251 0.0026143735467005487 12.178061351672735 0.08600331193351615 4.049681913397436 0.39820389115516674 1.0000000000001104e-14 13.999999999999952 -2.715298212353931 IVGSKPLYVALAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVGSKPLYVALAQR 14 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 83412000.0 33109000.0 33700000.0 16603000.0 False True 43406219.62801205 28672091.361571115 14885080.827221885 1.0 0.6605526029976515 0.342925068222616 25.371398443830394 -7.363241416535439 0.25462219236844763 1.1181960923739747 6.900062276988246e-14 0.999914624767073 0.002479041808211832 0.11387442237110577 0.01925305369232362 0.018575631589620563 0.053400660327288164 4.3326996440935925e-08 7.363241416535439 -1.1181960923739056 down IVGSKPLYVALAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVGSKPLYVALAQR 14 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 47572100.0 23577000.0 9080100.0 14915000.0 False True 22828561.04039734 12705831.282095954 11008314.059591101 1.0 0.5565760916604319 0.4822167301789556 24.444336588806593 -13.999999999999998 0.2512426987595422 4.103224219315499 0.452669453057276 0.9995450377740857 0.004875646064658058 14.047620566867725 0.1586086083328394 22.01685303623529 0.03408101651181416 1.0000000000000041e-14 13.999999999999998 -3.650554766258223 IVGSKPLYVALAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVGSKPLYVALAQR 14 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 74247000.0 22446000.0 32126000.0 19675000.0 False True 34052223.022406206 26392864.29841631 15786227.626141166 1.0 0.7750702290728545 0.46358875353758555 25.021245648607866 -6.96655122064271 0.3303483981645266 1.0377945355673113 0.19066236518814877 0.9999416418404875 0.001680145202117427 0.07743844238921126 0.01302487325165809 0.004539382826240485 0.027160491040056807 1.0800622309509228e-07 6.96655122064271 -0.8471321703791626 down IVGSKPLYVALAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVGSKPLYVALAQR 14 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 81412000.0 33109000.0 24339000.0 23964000.0 False True 45350292.037082136 23263622.5016901 18304196.75407219 1.0 0.5129762446219276 0.40361805694889835 25.434608505353285 -13.999999999999998 0.20988331708009533 3.8152815264372597 0.33913324253068766 0.999489946311587 0.0058546447526584755 12.743986044824723 0.1452092067566134 14.794271607386836 0.06483152934042248 1.0000000000000041e-14 13.999999999999998 -3.4761482839065723 IVGSKPLYVALAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVGSKPLYVALAQR 14 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 50195000.0 23577000.0 15477000.0 11141000.0 False True 19605320.138196487 15393622.329056012 13470531.589836149 1.0 0.785175769665962 0.6870855204038161 24.22474186424087 -13.999999999934785 0.10545227789903401 2.0460269202252683 0.49476186961073676 0.9997661784266977 0.001998192155108286 12.041318117055763 0.0977662768127762 2.7062500249433303 0.17107449863231639 1.000000000150164e-14 13.999999999934785 -1.5512650506145316 IVGSKPLYVALAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVGSKPLYVALAQR 14 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 70842000.0 22446000.0 30418000.0 17978000.0 False True 29056789.47680754 28725211.560429007 14706188.469857614 1.0 0.9885886251595969 0.5061188360674106 24.792371970700316 -6.911992360647681 0.8820618213117829 1.0140134066676465 0.4410365902131973 0.9916518686390658 0.02103067898436823 0.10311511506083539 0.13173143267850423 0.017389544099266855 0.04869195419060747 1.2246377407703469e-07 6.911992360647681 -0.5729768164544492 IVGWYHTGPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVGWYHTGPK 10 0 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 22814100.0 6006500.0 8375100.0 8432500.0 False True 7874579.667028746 7125567.725884107 7559985.790251667 1.0 0.9048822955870536 0.960049438817122 22.90877148603329 -10.193261295946877 4.274259573643654 1.000022621966763 0.9324658672002135 0.6664590822435301 0.022521891940404836 5.165663567598136e-06 9.74977663608285e-07 0.0218144962556357 0.00726890936359879 6.408239049310941e-11 10.193261295946877 -0.06755675476654943 IVGWYHTGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVGWYHTGPK 10 0 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 14801800.0 3799100.0 1544500.0 9458200.0 False True 3678499.650022198 2161226.904461096 6980813.680082102 1.0 0.5875294576820346 1.8977339524933696 21.810686023421773 -6.822075592575631 1.3628772635913642 0.7781373012414853 1.9276296437620224 0.8890926848163987 0.18215971735897282 0.19079526565580748 0.6957844532332084 0.105017041025459 0.24192287905879106 1.5063448514860895e-07 6.822075592575631 1.1494923425205372 IVGWYHTGPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVGWYHTGPK 10 0 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 16958500.0 4910900.0 9036400.0 3011200.0 False True 7450194.334880817 7423783.8182845535 2416035.000144152 1.0 0.996455056685889 0.32429154080351946 22.8288466274241 -6.908056235870734 0.9088569624439807 1.0221128307673257 0.24093912629833758 0.9901673359877398 0.0315030418015934 0.10571813981006035 0.14583888154051733 0.025546535801108706 0.06960658971973842 1.2357874035956616e-07 6.908056235870734 -0.7811737044689882 down IVGWYHTGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVGWYHTGPK 10 0 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 18976300.0 6006500.0 4152400.0 8817400.0 False True 8227265.369559159 3968933.237849456 6734911.720053248 1.0 0.48241220619119557 0.8186087864592758 22.971981547556183 -10.143730315027224 5.36986801593646 1.0000088181796565 0.6505104963251146 0.5903075775448154 0.13725167915468003 1.4490202205977809e-05 2.310483117117398e-06 0.13289671991050359 0.044297788967026436 7.182401602792185e-11 10.143730315027224 -0.3494983218545419 IVGWYHTGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVGWYHTGPK 10 0 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 10813100.0 3799100.0 4917000.0 2097000.0 False True 3159119.9786665873 4890511.145051914 2535473.0045674937 1.0 1.548061225302408 0.8025883859079247 21.59109129885605 -6.709688411187852 1.7963174475344825 1.337041399946858 0.8043553827949939 0.46363388111977333 0.230960892622649 0.3756957212938139 2.362938644910068 0.10232626939103508 0.26005489784487207 1.9512440367447473e-07 6.709688411187852 -0.5326860171518641 IVGWYHTGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVGWYHTGPK 10 0 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 17416500.0 4910900.0 6351000.0 6154600.0 False True 6357256.858311248 5997561.267022311 5034525.951528842 1.0 0.9434196856748546 0.7919337009243042 22.59997294951655 -6.953976713541067 0.5133333863999645 1.0027133037604967 0.7259562792650696 0.9994775350530265 0.0020077667784089907 0.08192710704881861 0.02964973008256785 0.002299467876209825 0.01250549660806921 1.1117913388823735e-07 6.953976713541067 -0.27675702449542716 IVGWYHTGPK(ub)LHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVGWYHTGPKLHK 13 1 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 22490030.0 6579300.0 10556000.0 5354730.0 True False 8625526.014031842 8981085.946965717 4800673.905797139 1.0 1.04122182604927 0.5565659297748906 23.040181009255413 -6.886221027652237 1.0444560139442178 1.0284487079073876 0.5178378258943976 0.9783681069965016 0.03226877149108588 0.12226378001826828 0.24017580563630891 0.023649144999781473 0.05821126660787753 1.299508044611791e-07 6.886221027652237 -0.51061088201299 IVGWYHTGPK(ub)LHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVGWYHTGPKLHK 13 1 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 31190100.0 9070900.0 10090000.0 12029200.0 True False 8782949.244659623 14118989.618654884 8878391.651735384 1.0 1.6075453956698864 1.0108667834023741 23.06627403598579 -10.193717050326084 6.349976399984604 0.9999976624885254 1.3092060895361235 0.26365464305665376 0.24359302341456354 8.090999939544e-06 1.0272663363149558e-06 0.23585972289066628 0.078619310244743 6.401517685770671e-11 10.193717050326084 0.3092084270475981 IVGWYHTGPK(ub)LHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVGWYHTGPKLHK 13 1 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 10659000.0 6579300.0 1699400.0 2380300.0 True False 9011845.00889713 1624314.8888357028 1818122.1638173107 1.0 0.18024221313527525 0.2017480507068566 23.103391070778304 -9.952768088129394 6.613192964915051 1.0000000960294537 0.1909951332700081 0.9994702855854867 0.008779721423631936 1.2434756058146502e-08 1.9537795813760315e-09 0.008500929727870065 0.0028336429048329997 1.1148897222251901e-10 9.952768088129394 -0.8090049627594456 IVGYVLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVGYVLAK 8 0 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3 P41227 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 0 16858400.0 5663500.0 7712400.0 3482500.0 False True 7424903.345412024 6561739.982699733 3122164.306498838 1.0 0.8837475287478787 0.420498983118491 22.82394081490056 -6.9449622894852245 0.611662601471865 1.0051123976755625 0.27494084055099616 0.9987442228405643 0.008870530143482477 0.085574059739978 0.04483693259627432 0.009002553592666772 0.03908524367091107 1.1351093748349335e-07 6.9449622894852245 -0.7301715571245664 down IVGYVLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVGYVLAK 8 0 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3 P41227 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 0 10782900.0 5663500.0 5119400.0 0.0 False True 7757449.000332693 4893207.980408078 0.0 1.0 0.6307753979688714 0.0 22.88715087642345 -7.577980901290269 0.6857395677195329 0.9956662549752296 9.582990794003395e-21 0.98708840351181 0.046914849543031364 0.12098871782385112 0.145610698679298 0.042198767114991785 0.07684447932496082 2.6425249635129874e-08 7.577980901290269 -0.9956662549752296 down IVHELNTTVPTASFAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVHELNTTVPTASFAGK 17 0 C9JQ41;H7C525;Q4VC31 C9JQ41 CCDC58 Coiled-coil domain-containing protein 58 0 6914000.0 2263900.0 2035400.0 2614700.0 False True 2967994.823638788 1731726.2539270574 2344155.9259734396 1.0 0.5834667365773724 0.7898113255802393 21.501057145138294 -10.136831174971702 5.135895861811633 1.0000115584495788 0.6866390310784164 0.7546000534016799 0.08423982570824541 1.114935073807235e-05 1.873816707174934e-06 0.08156786777887493 0.027188286837759253 7.29741130308413e-11 10.136831174971702 -0.3133725273711624 IVHELNTTVPTASFAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVHELNTTVPTASFAGK 17 0 C9JQ41;H7C525;Q4VC31 C9JQ41 CCDC58 Coiled-coil domain-containing protein 58 0 9131500.0 2263900.0 2170100.0 4697500.0 False True 3100925.0095971 2074217.8064389564 3588047.2480493276 1.0 0.6689029241337434 1.1570893320362878 21.564267206661185 -6.724054422112822 1.7445972947536896 0.7994390943208315 1.1565128983254762 0.5315785054611513 0.13926278332872893 0.34752805695917827 2.0692327679150173 0.06332807589589022 0.1582318267467118 1.8877547768049754e-07 6.724054422112822 0.3570738040046447 IVHK(ub)GDECILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVHKGDECILK 11 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 3812900.0 1244200.0 1057200.0 1511500.0 True False 1631158.2488499405 899469.8809333243 1355104.4793318005 1.0 0.551430176420652 0.8307621166047049 20.637465323020837 -10.385760273922157 6.148470730148264 1.0000516640382195 0.6910961465126787 0.6198568260972395 0.11403678705209393 8.077456631291979e-05 8.06944966059259e-06 0.11043405070775232 0.03680521475898006 4.113767341616213e-11 10.385760273922157 -0.30895551752554085 IVHK(ub)GDECILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVHKGDECILK 11 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 3792600.0 1244200.0 1043300.0 1505100.0 True False 1704214.3632407403 997203.5562682652 1149626.3785075115 1.0 0.5851397440237385 0.6745785056765851 20.70067538454373 -9.99074259669033 5.8259648764189995 1.0000004880551108 0.6298591248500621 0.9580467660896427 0.036513221546360844 2.3148550078291123e-07 4.014876131835149e-08 0.03535382109915455 0.011784591580397439 1.0215447667731336e-10 9.99074259669033 -0.37014136320504865 IVHYYFDHNSNWNLLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVHYYFDHNSNWNLLIR 17 0 Q9H6E4 Q9H6E4 CCDC134 Coiled-coil domain-containing protein 134 0 19716800.0 6103700.0 8935800.0 4677300.0 False True 7901359.971914382 8438514.874800507 3826079.3931507897 1.0 1.0679825884145842 0.4842304877578926 22.913669558800795 -6.87788113024346 1.0915006781859784 1.0410663782484326 0.4444975670326066 0.9719378617949904 0.04366204662548853 0.12952581661408905 0.28374205679039316 0.030869770627293822 0.07426823105204096 1.3247040673208948e-07 6.87788113024346 -0.5965688112158261 down IVIADVKLVADFQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVIADVKLVADFQR 14 1 C9J3B6;F8WBE4;C9JH62;G5E9M4;Q9NRM2 C9J3B6 ZNF277 Zinc finger protein 277 0 20602500.0 7423800.0 3964400.0 9214300.0 False True 11262447.352478795 3256921.846001421 7393089.566228841 1.0 0.28918420162777436 0.6564372142970922 23.42501702623301 -10.677558477054573 6.791944176242769 1.0034037821511577 0.47281070796374236 0.7331569963789637 0.14993041458995246 0.007755535540351984 0.0003681867510795626 0.14569334344167223 0.0483898332330716 2.1010748436457804e-11 10.677558477054573 -0.5305930741874153 IVIADVKLVADFQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVIADVKLVADFQR 14 1 C9J3B6;F8WBE4;C9JH62;G5E9M4;Q9NRM2 C9J3B6 ZNF277 Zinc finger protein 277 0 15795800.0 7423800.0 4221000.0 4151000.0 False True 9610255.44497566 3986097.6394427973 3395560.5928567625 1.0 0.41477540969285787 0.3533267780756022 23.19614334832546 -13.999999999999998 0.31840463122862067 6.944006160299381 0.3409089995705508 0.9996902972478952 0.005128915549926425 17.89038820848136 0.17988167870796334 70.77784352513687 0.020586983340554667 1.0000000000000041e-14 13.999999999999998 -6.60309716072883 IVIEK(ub)QGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVIEKQGK 8 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2 E9PFW3 AP2M1 AP-2 complex subunit mu 1 24108600.0 7395700.0 9557200.0 7155700.0 True False 9695834.320060682 8131303.013673812 6415296.806321247 1.0 0.8386388159346067 0.6616549535142114 23.20893361594145 -6.9699384326690375 0.2596532021639794 1.0498992164319818 0.4451460889640037 0.9999818966482424 0.0005878912777170934 0.07632269485192342 0.009101637855899548 0.003702872148687081 0.01670740062233133 1.0716712188878966e-07 6.9699384326690375 -0.604753127467978 IVIEK(ub)QGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVIEKQGK 8 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2 E9PFW3 AP2M1 AP-2 complex subunit mu 1 31456200.0 12667000.0 12445000.0 6344200.0 True False 12264893.018565236 17414353.399817657 4682463.698079636 1.0 1.4198536728740918 0.3817777856677463 23.548031314147938 -6.796886929000892 1.4683843876601723 1.2325699754403947 0.36848951471519675 0.8229856811390088 0.17938447824877285 0.225216225630844 0.9589537993980985 0.09611794810330501 0.2239923817890617 1.5962946973979028e-07 6.796886929000892 -0.864080460725198 down IVIEK(ub)QGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVIEKQGK 8 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2 E9PFW3 AP2M1 AP-2 complex subunit mu 1 27221600.0 12114000.0 7188900.0 7918700.0 True False 18377823.65202836 5905984.627867937 6353565.474110495 1.0 0.321364745885789 0.3457191446827956 24.131462593388513 -10.286549461613758 5.624195890166651 1.0000647421675424 0.333541945284322 0.9989994567969054 0.009942641674190646 8.072227217745068e-06 1.0239947122658512e-06 0.009627849729416414 0.0032089738017818882 5.1695237912937254e-11 10.286549461613758 -0.6665227968832204 IVIEK(ub)QGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVIEKQGK 8 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2 E9PFW3 AP2M1 AP-2 complex subunit mu 1 20754500.0 7395700.0 7362600.0 5996200.0 True False 10130090.151277559 7037295.987137667 4580021.055615401 1.0 0.6946923356106713 0.45212046361085845 23.272143677464342 -7.357931695016236 0.17342350846621352 1.2334141927960822 3.008697711611341e-11 0.9999848761852603 0.0008717211757372118 0.11575926917819511 0.011879732977095738 0.02531284852148458 0.052617455002431944 4.385996744465832e-08 7.357931695016236 -1.2334141927659952 down IVIEK(ub)QGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVIEKQGK 8 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2 E9PFW3 AP2M1 AP-2 complex subunit mu 1 30900700.0 12667000.0 13401000.0 4832700.0 True False 10533171.743246997 13328806.153109752 5843195.226119852 1.0 1.2654124016970563 0.5547422342055732 23.328436589582214 -6.805543183439722 1.4329958627950559 1.1454291327256707 0.5435151667717729 0.847918729115958 0.11434496049898751 0.21294081069397258 0.8625773549361623 0.06275524089689832 0.14549324187224885 1.5647927186025117e-07 6.805543183439722 -0.6019139659538978 IVIEK(ub)QGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVIEKQGK 8 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2 E9PFW3 AP2M1 AP-2 complex subunit mu 1 23195500.0 12114000.0 6799400.0 4282100.0 True False 15681811.802639503 6421007.412847041 3502801.7380563617 1.0 0.40945571172881196 0.22336715821744418 23.902588915480962 -13.999999999999988 0.16164182055744789 3.918667428230675 0.04370683842714694 0.9995321458910681 0.007161252608410098 12.021044055484726 0.12710656339842508 10.998844915755788 0.16408854053188873 1.0000000000000286e-14 13.999999999999988 -3.874960589803528 IVIEK(ub)QGK(ub)GTADETSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVIEKQGKGTADETSK 16 2 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2 E9PFW3 AP2M1 AP-2 complex subunit mu 2 2564330.0 679430.0 1345900.0 539000.0 True False 564976.1488524763 1338649.3695597672 651702.4079455785 1.0 2.369390942040119 1.1535042837989744 19.10783043814416 -6.617632378924922 2.125917469402103 1.91016981229072 1.1581311064564423 0.07468621916737284 0.5892506554622692 0.5918458592127341 5.079662462050778 0.22803811348591618 0.6533584380974735 2.411946226183742e-07 6.617632378924922 -0.7520387058342777 IVIFTQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVIFTQGR 8 0 P55263;A0A5K1VW54;P55263-3;P55263-4;P55263-2;A0A5F9ZHJ1;A0A5K1VW94 P55263 ADK Adenosine kinase 0 11352200.0 3992500.0 3437700.0 3922000.0 False True 5234206.163424997 2924808.560049649 3516189.062480527 1.0 0.5587874204282018 0.671771220448014 22.319539319291554 -10.074798844738776 7.399262594536435 1.0000000548705401 0.6152793204381162 0.9392450749955908 0.04612544320819936 4.171414935740003e-08 5.3065222503764365e-09 0.0446607743348847 0.014886922781815998 8.417849468792577e-11 10.074798844738776 -0.38472073443242394 IVIFTQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVIFTQGR 8 0 P55263;A0A5K1VW54;P55263-3;P55263-4;P55263-2;A0A5F9ZHJ1;A0A5K1VW94 P55263 ADK Adenosine kinase 0 14809900.0 3992500.0 5385800.0 5431600.0 False True 5468635.143255625 5147837.547541085 4148767.947313402 1.0 0.9413386361841721 0.7586477866291751 22.382749380814445 -6.950607347084806 0.5521411687633627 1.0024950840929 0.6888772941320102 0.9992480480121985 0.0028183183825625465 0.08324288898392083 0.03496091089268323 0.0030505887755097605 0.015161960060564531 1.1204504436746822e-07 6.950607347084806 -0.31361778996088974 IVIFTQGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVIFTQGR 8 0 P55263;A0A5K1VW54;P55263-3;P55263-4;P55263-2;A0A5F9ZHJ1;A0A5K1VW94 P55263 ADK Adenosine kinase 0 5688500.0 2862800.0 1741200.0 1084500.0 False True 2380545.0435436578 1731819.8099988606 1311263.9358385517 1.0 0.7274887802252585 0.550825089151271 21.18286049646764 -8.683763014705525 0.1011024638321962 1.583028567177965 1.1917477556970773e-08 0.9999732678430374 0.0009552564885884474 0.2480064837402748 0.02739941145268665 0.22369264278624318 0.18563412894613557 2.0712712893154193e-09 8.683763014705525 -1.5830285552604875 IVIGYQSHADTATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVIGYQSHADTATK 14 0 P06730;P06730-2;D6RBW1;P06730-3 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 84758000.0 29186000.0 22658000.0 32914000.0 False True 38263128.637626074 19277514.72019226 29508375.013381995 1.0 0.5038143875468589 0.7711960852141326 25.18945150667365 -10.068674342139857 5.225011253487207 1.0000049330406524 0.6375052363798391 0.7101983747453621 0.10915812097628814 6.272885630910946e-06 1.1180036866379642e-06 0.10569333527742411 0.03523063205337391 8.537400552489948e-11 10.068674342139857 -0.3624996966608133 IVIGYQSHADTATK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVIGYQSHADTATK 14 0 P06730;P06730-2;D6RBW1;P06730-3 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 56878800.0 11299000.0 6845800.0 38734000.0 False True 10940319.429759908 9579363.640375387 28588403.40490789 1.0 0.875601823317659 2.6131232811303096 23.38315152601685 -6.889700997449524 1.0241692022433162 0.9059703267839776 2.7616830474910135 0.9807055241311926 0.1099270846267636 0.11938530777241706 0.2232769625550482 0.08181525858273941 0.20374478217084233 1.28913678960575e-07 6.889700997449524 1.8557127207070359 up IVIGYQSHADTATK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVIGYQSHADTATK 14 0 P06730;P06730-2;D6RBW1;P06730-3 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 55826000.0 14574000.0 28416000.0 12836000.0 False True 22109823.502118316 23344942.784778632 10298958.973781334 1.0 1.0558629191473186 0.465809189874112 24.398184172692904 -6.88369721168196 1.058926810422961 1.0366577323289208 0.42090419785288474 0.976548893832502 0.04072946405625751 0.1244071405574488 0.25290328344059526 0.029522501664232936 0.07211554068097446 1.3070818626041517e-07 6.88369721168196 -0.6157535344760361 down IVIGYQSHADTATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVIGYQSHADTATK 14 0 P06730;P06730-2;D6RBW1;P06730-3 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 71613000.0 29186000.0 17120000.0 25307000.0 False True 39976852.92199345 16363581.791730756 19330007.814025417 1.0 0.4093264125533067 0.4835300030180946 25.25266156819654 -10.533147678850943 6.2942053544428065 1.0006378368005142 0.4464282077863774 0.9867031210062538 0.030293488953530297 0.00027143413046148274 2.0132745588507576e-05 0.029362820368768958 0.009777181517961756 2.929896784594071e-11 10.533147678850943 -0.5542096290141368 IVIGYQSHADTATK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVIGYQSHADTATK 14 0 P06730;P06730-2;D6RBW1;P06730-3 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 33748200.0 11299000.0 13385000.0 9064200.0 False True 9395619.130571403 13312892.34828552 10959482.311874423 1.0 1.4169255014784625 1.1664459956890476 23.163556801451126 -10.308009381778124 4.878074581897978 0.9998771618223581 1.2916857485839452 0.6438885480245392 0.10225783003541866 0.0001366666684910724 1.938700678288456e-05 0.09905222221248203 0.0330035727287802 4.9202890658970724e-11 10.308009381778124 0.29180858676158716 IVIGYQSHADTATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVIGYQSHADTATK 14 0 P06730;P06730-2;D6RBW1;P06730-3 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 43004000.0 14574000.0 18242000.0 10188000.0 False True 18866330.296489026 17226816.663993236 8333888.537707709 1.0 0.9130984347920115 0.4417334164481697 24.169310494785353 -6.938006548764057 0.6778552964748131 1.0055177257547852 0.32174456803367124 0.9978909657819178 0.011263646232372455 0.08868795857349335 0.058840059739906095 0.01080528903405223 0.04093854372799294 1.1534358649307843e-07 6.938006548764057 -0.6837731577211139 down IVILEYQPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVILEYQPSK 10 0 Q15393;Q15393-2;J3QL37;J3QRB2 Q15393 SF3B3 Splicing factor 3B subunit 3 0 23553600.0 7033400.0 7253400.0 9266800.0 False True 9220855.511542477 6171220.993531746 8307960.429422375 1.0 0.6692677253001892 0.9009967045923929 23.136469179523413 -10.100820388842878 5.494578434492296 1.000002463533128 0.7851322149462197 0.5340947195384537 0.09460295964722927 2.854970439573005e-06 4.6715327215532753e-07 0.09159997203643314 0.03053297393460119 7.928291530183669e-11 10.100820388842878 -0.21487024858690829 IVILEYQPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVILEYQPSK 10 0 Q15393;Q15393-2;J3QL37;J3QRB2 Q15393 SF3B3 Splicing factor 3B subunit 3 0 25616100.0 5390200.0 14528000.0 5697900.0 False True 8177327.47640444 11935364.892217917 4571707.567521714 1.0 1.4595679244419697 0.5590711122568235 22.96319798626612 -6.767961765785301 1.5822199995078945 1.2642753965056703 0.5543853389222729 0.7227496953449661 0.1935858363885018 0.26972059844122737 1.332258078111755 0.09645773194330813 0.23004479655309726 1.7062325948992017e-07 6.767961765785301 -0.7098900575833974 IVILEYQPSK(ub)NMFEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVILEYQPSKNMFEK 15 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 15080400.0 3163800.0 5293800.0 6622800.0 True False 4147772.438282779 4503985.675070777 5937536.186383486 1.0 1.0858806123258473 1.4314999857710824 21.983905314206584 -6.9447353976853945 0.6139360128852881 0.996196347172622 1.539304829508769 0.9987206037896004 0.006670639663491064 0.08567130129538893 0.04526116007504245 0.00675552637505638 0.02918440066742899 1.1357025536747363e-07 6.9447353976853945 0.5431084823361471 IVILEYQPSK(ub)NMFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVILEYQPSKNMFEK 15 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 28103700.0 5821500.0 8376200.0 13906000.0 True False 5636699.669027994 11720860.34130596 10263601.428942239 1.0 2.0793835097705555 1.8208529869593209 22.426419270110596 -10.160741536155872 4.619145939568462 0.9998739596235314 1.9501182483766357 0.9473911373646331 0.10554464401101384 73910032.20403235 24.29625916250703 99220.4506325071 0.036130738961850505 6.906507119629247e-11 10.160741536155872 0.9502442887531043 IVILEYQPSK(ub)NMFEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVILEYQPSKNMFEK 15 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 66353000.0 11510000.0 26788000.0 28055000.0 True False 17461511.493713584 22007472.104400694 22509916.953056693 1.0 1.2603417586343386 1.2891161776665563 24.057675110355476 -12.593879690418703 0.3334041592050162 8.74393743626056e-09 1.2942602375316072 0.9996392355396712 0.0024699499076219636 7.672396270040758 0.18081535312639488 5.2584137848255725 0.009105187632953754 2.5475358809986235e-13 12.593879690418703 1.2942602287876699 IVILEYQPSK(ub)NMFEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVILEYQPSKNMFEK 15 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 12211800.0 3163800.0 0.0 9048000.0 True False 4333542.358480184 0.0 6911048.749409322 1.0 0.0 1.5947804769659835 22.047115375729476 -6.737185204676987 1.6968481972376661 0.40305973703738607 1.5951744926192097 0.5922358567064494 0.4201974388076317 0.3229687402661066 1.824759225429444 0.19598471488083022 0.48245145490719227 1.8315331993378799e-07 6.737185204676987 1.1921147555818237 IVILEYQPSK(ub)NMFEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVILEYQPSKNMFEK 15 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 19414800.0 5821500.0 8328100.0 5265200.0 True False 4840835.1861776635 8283234.872301576 6366128.976465786 1.0 1.711116894860046 1.3150889736224418 22.206824545544873 -10.226563075837298 4.556571017971983 0.999871630989022 1.5131029342390887 0.6911850970805723 0.16167772248459314 0.00025210507988539097 4.279281391372224e-05 0.15659018386739987 0.052181260453195724 5.935221402696374e-11 10.226563075837298 0.5132313032500667 IVILEYQPSK(ub)NMFEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVILEYQPSKNMFEK 15 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 56095000.0 11510000.0 21380000.0 23205000.0 True False 14899921.896019533 20190184.20546955 18981928.103406683 1.0 1.3550530228526427 1.2739615842199579 23.828801432447925 -10.062687658932427 4.283397931842451 0.999972250308008 1.3145073035264976 0.9525082087639367 0.03310544141579318 23140613.81547689 29958507.13481476 8817.139354574147 0.012115351479587342 8.655902204349623e-11 10.062687658932427 0.3145350532184896 IVILPDYLEIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVILPDYLEIAR 12 0 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 8412100.0 1344800.0 4397500.0 2669800.0 False True 1763045.823061724 3741410.1413207464 2393554.7065299656 1.0 2.1221287004460123 1.3576247850287255 20.749638541341763 -10.1868049514491 4.885451764869983 0.9999212353490082 1.7398767427391784 0.5553213318336127 0.3121074165282974 0.0002677881846494466 4.457339637065758e-05 0.30222863188946564 0.10073223553593406 6.504217394918449e-11 10.1868049514491 0.7399555073901701 IVILPDYLEIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVILPDYLEIAR 12 0 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 15342600.0 7986500.0 3434400.0 3921700.0 False True 7732972.929089084 4805773.830159399 2894489.1215218455 1.0 0.621465233905261 0.3743048305049227 22.882591731920957 -8.39213528707412 0.17217374785424094 1.3551859739134184 9.604462764211955e-07 0.9998514056748141 0.0031365726285398597 0.11446039303222634 0.04011283733809084 0.14184665264973337 0.1315920865711158 4.053822351573707e-09 8.39213528707412 -1.355185013467142 down IVILPDYLEIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVILPDYLEIAR 12 0 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 15209500.0 1344800.0 4437500.0 9427200.0 False True 1842008.901853516 4241436.577149834 7200689.519278478 1.0 2.3026145926232497 3.9091502283364674 20.812848602864655 -6.968305841538071 0.2958651450571351 0.7073208147608834 5.554489632296101 0.999965988829099 0.0069388855264082665 0.07685632732065248 0.010987277104617806 0.027215067458131657 0.14472735496502884 1.0757074055246647e-07 6.968305841538071 4.847168817535218 IVILPDYLEIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVILPDYLEIAR 12 0 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 11892900.0 7986500.0 1267900.0 2638500.0 False True 6641128.611939866 1261069.5710415551 3190198.150954375 1.0 0.1898878405658821 0.48036987948386106 22.662997007355234 -10.415078528424424 5.948809679163249 1.0002203692381444 0.3351288600516426 0.8747673844630037 0.11858879579872339 0.0003467100640772014 3.4090307880115175e-05 0.11486011034210698 0.0382743692646038 3.8452224706936305e-11 10.415078528424424 -0.6650915091865017 IVIQK(ub)YHTVNGHNCEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVIQKYHTVNGHNCEVR 17 1 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 10355800.0 2444500.0 5630600.0 2280700.0 True False 3204763.1725716763 4790536.4279069 2044715.0420192096 1.0 1.4948176105202533 0.6380237577363381 21.611786317001098 -6.750120470405531 1.6494924530694643 1.2909176251318757 0.6363151962155558 0.6494484643721463 0.20792643650295967 0.29983660947334334 1.605146454248824 0.09957837881440149 0.24170992298029595 1.7777861955488645e-07 6.750120470405531 -0.6546024289163199 IVIQK(ub)YHTVNGHNCEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVIQKYHTVNGHNCEVR 17 1 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 33576200.0 6252000.0 9814200.0 17510000.0 True False 9484741.082423748 8062779.331305401 14049140.825094357 1.0 0.850079012303942 1.4812360931105368 23.177176960335547 -6.844044905354898 1.2634695487837333 0.9202381970217228 1.5037153614830965 0.9311901542129124 0.07062669993502484 0.16412558100059155 0.5071845241338723 0.04380014111711058 0.10104424743360864 1.4320398209907975e-07 6.844044905354898 0.5834771644613737 IVIQK(ub)YHTVNGHNCEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVIQKYHTVNGHNCEVR 17 1 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 15477300.0 2444500.0 9229700.0 3803100.0 True False 3348297.7101285886 8821901.335463619 2904886.107303118 1.0 2.634742218046322 0.8675710342350526 21.67499637852399 -6.663615963739947 1.959864035798747 2.0490960753045213 0.8748488031760653 0.2511938689481443 0.6954351491317455 0.4759127203440124 3.5177166777463476 0.2862924425071048 0.7713654880825053 2.1696218016597716e-07 6.663615963739947 -1.174247272128456 IVIQK(ub)YHTVNGHNCEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVIQKYHTVNGHNCEVR 17 1 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 13780000.0 2525100.0 3701100.0 7553800.0 True False 2099732.530897056 3681161.439689169 9133264.65517498 1.0 1.7531573119536747 4.349727653775517 21.001774134870665 -6.948290078054419 0.577310559688649 0.9686392453170385 5.26208433779875 0.9990601775235649 0.043988638775966496 0.0841797091565682 0.03886059414898935 0.046223814878903265 0.21674957076763113 1.1264448192326717e-07 6.948290078054419 4.293445092481711 IVIQK(ub)YHTVNGHNCEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVIQKYHTVNGHNCEVR 17 1 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 85768000.0 6252000.0 25814000.0 53702000.0 True False 8093337.245344408 24377428.207670297 43928787.02905173 1.0 3.01203662576808 5.427771721031546 22.948303282427997 -6.968692263401419 0.2877108913289119 0.5148699524891472 7.999337311027995 0.9999703097949613 0.009863180581300037 0.0767293494237992 0.010541425720101695 0.04273097953820966 0.21965650245609616 1.0747506998699297e-07 6.968692263401419 7.484467358538848 IVISVNWTPLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVISVNWTPLK 11 0 Q8IZT6;Q8IZT6-2 Q8IZT6 ASPM Abnormal spindle-like microcephaly-associated protein 0 12714900.0 2401100.0 3852600.0 6461200.0 False True 3642644.243923168 3165073.4294988075 5184140.987955441 1.0 0.8688944671934222 1.423180700833981 21.79655467157205 -6.84433144844764 1.2621348283030407 0.9302448971286659 1.4430311604944257 0.9316486030911262 0.061837769350416925 0.16379830170138915 0.5049745555509123 0.038388161697710865 0.0885687274384934 1.4310952872777452e-07 6.84433144844764 0.5127862633657598 IVISVNWTPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVISVNWTPLK 11 0 Q8IZT6;Q8IZT6-2 Q8IZT6 ASPM Abnormal spindle-like microcephaly-associated protein 0 9651800.0 2401100.0 3471300.0 3779400.0 False True 3108271.282756949 3278119.1034820606 3091587.9799187765 1.0 1.0546438213637714 0.994632610438245 21.5676809936645 -6.667073383748806 1.9476252545286044 1.0349670927370085 0.9948777690774562 0.26608864690325285 0.02322745487432561 0.46794374180218096 3.4191676987713144 0.00961048833261333 0.02577633681050821 2.1524180049181378e-07 6.667073383748806 -0.04008932365955231 IVITGDADIDHDQALAQAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVITGDADIDHDQALAQAIK 20 0 A8K968;A0A0A0MRA8;Q9Y2J2-2;Q9Y2J2;A0A0A0MSA4 A8K968 EPB41L3 Band 4.1-like protein 3;Band 4.1-like protein 3, N-terminally processed 0 29503800.0 8518800.0 10362000.0 10623000.0 False True 8248375.356955364 14499600.637116147 7840517.6168311285 1.0 1.757873521709884 0.9505529607378604 22.975678555921604 -6.660419812186014 1.971456209719363 1.4876666106424847 0.9539202146434687 0.23737729982492461 0.32265321495877464 0.4834426454157594 3.6125042646863306 0.13220734852853597 0.3576812094368211 2.1856478388101687e-07 6.660419812186014 -0.5337463959990161 IVITGDADIDHDQALAQAIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVITGDADIDHDQALAQAIK 20 0 A8K968;A0A0A0MRA8;Q9Y2J2-2;Q9Y2J2;A0A0A0MSA4 A8K968 EPB41L3 Band 4.1-like protein 3;Band 4.1-like protein 3, N-terminally processed 0 72363000.0 15448000.0 14709000.0 42206000.0 False True 23435745.400077093 12084064.028058449 33863965.60045307 1.0 0.5156253330870669 1.4449707070269535 24.482207346286533 -6.765064709779753 1.5932295313898353 0.7204205492502886 1.449262621347961 0.7113296197789202 0.2039072716326443 0.27450703191348097 1.374325361222768 0.1009246496545299 0.24135788689782564 1.717652438264391e-07 6.765064709779753 0.7288420720976723 IVIYVQQTTNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVIYVQQTTNK 11 0 Q9Y3P9-2;Q9Y3P9;Q9Y3P9-3 Q9Y3P9-2 RABGAP1 Rab GTPase-activating protein 1 0 7688600.0 2864400.0 1813100.0 3011100.0 False True 3755256.1388890557 1542592.5474084471 2699540.2565107434 1.0 0.4107822450334382 0.7188698071896017 21.84047988390853 -10.567243550988744 6.540348383504986 1.0006431095698851 0.564826026111545 0.7267917741373704 0.1257762205634329 0.0011811001001011154 7.814998899165272e-05 0.12195079958153504 0.04059410063259054 2.7086721909788185e-11 10.567243550988744 -0.43581708345834014 IVIYVQQTTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVIYVQQTTNK 11 0 Q9Y3P9-2;Q9Y3P9;Q9Y3P9-3 Q9Y3P9-2 RABGAP1 Rab GTPase-activating protein 1 0 6418200.0 2864400.0 1881800.0 1672000.0 False True 3923446.087499413 1798655.8537195642 1277108.0359209105 1.0 0.45843776455863766 0.3255067120687437 21.90368994543142 -13.999999999999998 0.19727915733524512 3.9798527501043495 0.2368233935071873 0.999487022263969 0.006607152062223638 12.478396592206508 0.14084562635351205 14.331959111036642 0.08639337150234087 1.0000000000000041e-14 13.999999999999998 -3.743029356597162 IVK(ub)ADEHVIDQGDDGDNFYVIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVKADEHVIDQGDDGDNFYVIER 23 1 P13861-2;P13861;H7C1L0 P13861-2 PRKAR2A cAMP-dependent protein kinase type II-alpha regulatory subunit 1 5831500.0 2966200.0 1788500.0 1076800.0 True False 2466526.7249403372 1778864.9955105449 1301953.90143933 1.0 0.7212024007376502 0.527849095764743 21.234049488414136 -7.873778002565486 0.12071949752546737 1.4192390917456958 1.2148058795126493e-15 0.9999837594841555 0.0007809997333956017 0.12352653016180135 0.017590495067000986 0.08589276561708802 0.1076305845847273 1.3372789160323371e-08 7.873778002565486 -1.4192390917456947 IVK(ub)EAHEPLAVADAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVKEAHEPLAVADAK 15 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 1 4269430.0 1573300.0 1804800.0 891330.0 True False 2062611.5358588723 1535530.8750552982 799103.7218410929 1.0 0.7444595593304012 0.3874232776984571 20.976040704624314 -6.966410497869402 0.3329593341075449 1.0420244462015005 0.07811844425443867 0.9999393352833738 0.001956721754548683 0.07748554261154553 0.01318987149787786 0.0051562149162173295 0.031068329778414904 1.0804122560738332e-07 6.966410497869402 -0.9639060019470618 down IVK(ub)EAHEPLAVADAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVKEAHEPLAVADAK 15 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 1 6197000.0 1494300.0 2369600.0 2333100.0 True False 1446864.2644384666 3315793.637300751 1721991.1185002974 1.0 2.2917102307365527 1.1901538802387994 20.464498153110373 -6.60732048890778 2.163010498054232 1.864548696496502 1.1939631335943472 0.04216718784539131 0.5572803136554239 0.6202486541787864 5.494728925057227 0.21301570003404618 0.6191798708005746 2.469900801667388e-07 6.60732048890778 -0.6705855629021547 IVK(ub)EAHEPLAVADAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVKEAHEPLAVADAK 15 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 1 4384700.0 1573300.0 1191400.0 1620000.0 True False 2154991.5268338323 1138760.008567056 1237389.3649472937 1.0 0.528428995839325 0.5741968585673732 21.039250766147205 -10.209725633854946 8.310285137239758 1.000000121489448 0.5513129278130456 0.9922568165972239 0.018684651716910448 4.2075472416639535e-08 3.990067036725708e-09 0.018091341354278628 0.006030445410773338 6.169846596849199e-11 10.209725633854946 -0.4486871936764024 IVK(ub)EAHEPLAVADAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVKEAHEPLAVADAK 15 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 1 6625200.0 1494300.0 3549700.0 1581200.0 True False 1242576.6587142977 3530577.061539712 1911821.6093572348 1.0 2.8413354112033806 1.5385944971277743 20.24490342854465 -10.490711458853035 5.157510842885994 0.9971889213437916 2.1899649541655974 0.5266220260423842 0.531841751088766 0.017212094243585163 0.0016996408061357934 0.5155900063363564 0.1716511870653718 3.230639815387914e-11 10.490711458853035 1.192776032821806 IVK(ub)EAHEPLAVADAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVKEAHEPLAVADAK 15 1 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 1 9833500.0 2700300.0 1396800.0 5736400.0 True False 3495591.5808706824 1319066.8521141203 4692434.060434483 1.0 0.37735153595534376 1.3423862461831686 21.737105201910648 -6.732495590885268 1.7140277887030448 0.6263380109126423 1.3420897027692795 0.5708290712418482 0.26169961551401333 0.3315852804480142 1.9095587123736968 0.12093567308152096 0.2992613337224338 1.851417690372197e-07 6.732495590885268 0.7157516918566372 IVK(ub)MNK(ub)SEDDESGAGELTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVKMNKSEDDESGAGELTR 19 2 P33993;P33993-3;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 2 38336200.0 1797800.0 3927400.0 32611000.0 True False 2727394.036785254 3226524.7850837433 26165421.556090932 1.0 1.183006467553478 9.593561180815588 21.379091716166712 -6.911594770989541 0.8847941363861427 0.7525423919819195 10.718432418480953 0.9915098314943144 0.36936131068779227 0.10337312535590419 0.1331130512000863 0.30480588722530483 0.8510074918510451 1.2257593904000827e-07 6.911594770989541 9.965890026499034 up IVK(ub)MNK(ub)SEDDESGAGELTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVKMNKSEDDESGAGELTR 19 2 P33993;P33993-3;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 2 35794800.0 1797800.0 3041000.0 30956000.0 True False 2327287.5399360475 2871765.6767461565 25322325.635382786 1.0 1.2339539603366205 10.88061754332197 21.150218038259162 -6.91211787237036 0.88119583622362 0.7209541731976953 12.18542496573643 0.9916964000639336 0.4195002493035349 0.10303393622267493 0.13129646268944956 0.34708827534043596 0.9727711289743725 1.2242838698593353e-07 6.91211787237036 11.464470792538735 up IVK(ub)PNGEKPDEFESGISQALLELEMNSDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVKPNGEKPDEFESGISQALLELEMNSDLK 30 2 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 70362000.0 22130000.0 21789000.0 26443000.0 True False 28647721.247516263 20576422.99592966 21630645.328092366 1.0 0.7182568839646756 0.7550564019107707 24.771917050116706 -10.429042648653514 9.00354701155942 1.0000019049387425 0.7366566430154019 0.9855660044684249 0.015023340291387592 5.744659194432569e-07 3.644943271634307e-08 0.014546391792994176 0.004848762229412587 3.723551383825018e-11 10.429042648653514 -0.2633452619233406 IVKPNGEKPDEFESGISQALLELEMNSDLK(ub)AQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVKPNGEKPDEFESGISQALLELEMNSDLKAQLR 34 3 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 98887000.0 29536000.0 23942000.0 45409000.0 True False 44808271.3708362 19669363.040300187 36433891.246528305 1.0 0.4389672361496663 0.813106378172883 25.417261734981658 -9.95855363767194 5.638154746845464 1.0000005023346172 0.6260368071608979 0.5711981614728493 0.1527416651279786 9.643959861089937e-07 1.7823471166704678e-07 0.14789167965916825 0.049297160442519666 1.1001359642783693e-10 9.95855363767194 -0.3739636951737193 IVKPNGEKPDEFESGISQALLELEMNSDLK(ub)AQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IVKPNGEKPDEFESGISQALLELEMNSDLKAQLR 34 3 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 225917800.0 48848100.0 28987000.0 148082700.0 True False 63234828.390004545 27373847.968379103 121133168.05681284 1.0 0.4328919468168598 1.9156083939963726 25.914216047069367 -6.803041659588249 1.443494505913104 0.6882957053409909 1.9376376770715016 0.8408916289140411 0.2436639965073399 0.21644926815670823 0.890065825712691 0.13277690590892333 0.30823145813602454 1.5738318877996625e-07 6.803041659588249 1.2493419717305105 IVKPVK(ub)VSAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVKPVKVSAPR 11 2 P83731 P83731 RPL24 60S ribosomal protein L24 1 4943300.0 1555400.0 1708500.0 1679400.0 True False 2039144.4625150266 1453598.4596808404 1505631.7979423248 1.0 0.7128472192146753 0.738364459026762 20.959532555552293 -10.325894877756863 6.608924089165211 1.000009621989556 0.7256058391207186 0.9935557659616185 0.010417369530640843 1.4769642655236771e-06 1.506550960667127e-07 0.010086928126879132 0.0033621915586217123 4.7217731932653807e-11 10.325894877756863 -0.2744037828688374 IVKPVK(ub)VSAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVKPVKVSAPR 11 2 P83731 P83731 RPL24 60S ribosomal protein L24 1 9642500.0 1887200.0 3269200.0 4486100.0 True False 1827291.8690010507 4574608.608652783 3311055.8298847824 1.0 2.503490923512752 1.8120016216647865 20.80127565995609 -10.084201078459259 4.836779255712839 0.999956938077554 2.1577462726001544 0.7889233388507453 0.28229932539272246 98098672.18765312 4.272058201473843 47047.09542729177 0.09663856779788019 8.237566271704588e-11 10.084201078459259 1.1577893345226005 IVKPVK(ub)VSAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVKPVKVSAPR 11 2 P83731 P83731 RPL24 60S ribosomal protein L24 1 10718610.0 1887200.0 7963100.0 868310.0 True False 1569290.4171355278 7920201.199748398 1049869.606388173 1.0 5.046995198126154 0.6690091234384334 20.581680935390366 -6.663780854837109 1.9593969510290175 3.596815185206187 0.6870691665654776 0.25187227455115313 1.7215661598320413 0.4755147218797037 3.513304318217768 0.7088709869748334 1.9094344256742006 2.1687982051646622e-07 6.663780854837109 -2.9097460186407096 IVLAAAGGVSHDELLDLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVLAAAGGVSHDELLDLAK 19 0 O75439;G3V0E4 O75439 PMPCB Mitochondrial-processing peptidase subunit beta 0 32478000.0 7451400.0 15068000.0 9958600.0 False True 11304318.570309091 12378997.673178647 7990278.344990562 1.0 1.095068012829381 0.7068341444284054 23.430370692579977 -6.8419743867795395 1.2733352999088399 1.0505658580164856 0.6935690233823886 0.9277726102780528 0.04440591642108749 0.16650739167002368 0.5235900740629819 0.0273373222738908 0.06301213470471843 1.438883436234593e-07 6.8419743867795395 -0.35699683463409704 IVLAAAGGVSHDELLDLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVLAAAGGVSHDELLDLAK 19 0 O75439;G3V0E4 O75439 PMPCB Mitochondrial-processing peptidase subunit beta 0 19371000.0 7451400.0 8717800.0 3201800.0 False True 9645984.18905301 8232646.7664378965 2619105.253242298 1.0 0.8534791893792366 0.2715228640136748 23.201497014672427 -6.945037008779569 0.6109076678766343 1.006428922987231 0.08821940951593306 0.9987519867010156 0.011114332434954688 0.08554197986697384 0.04469690071529752 0.011287776529047855 0.04908776723057794 1.1349140988658042e-07 6.945037008779569 -0.9182095134712979 down IVLLDSSLEYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVLLDSSLEYK 11 0 P49368;B4DUR8;P49368-2;Q5SZX6 P49368 CCT3 T-complex protein 1 subunit gamma 0 46105000.0 16785000.0 15638000.0 13682000.0 False True 22005297.546171226 13304871.35644658 12266317.887011375 1.0 0.6046212885115719 0.5574256772158771 24.391347543577872 -13.999999999999998 0.299876928547933 4.603969659773435 0.5457983606608335 0.999649555970975 0.0037149158566175846 16.580395759167796 0.1739087371973875 37.07408485874088 0.017065161926796017 1.0000000000000041e-14 13.999999999999998 -4.058171299112602 IVLLDSSLEYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVLLDSSLEYK 11 0 P49368;B4DUR8;P49368-2;Q5SZX6 P49368 CCT3 T-complex protein 1 subunit gamma 0 55054000.0 21261000.0 10680000.0 23113000.0 False True 20586081.192682996 14944579.695464222 17059011.92486282 1.0 0.7259555403277065 0.8286672808288632 24.29516588602397 -10.30809534388675 5.051988119932589 1.0000711543107341 0.7773114106781157 0.8624011382681367 0.041931892470363906 3.361637437986888e-05 4.603983306250115e-06 0.040613324638257224 0.013533460101028153 4.9193152645148634e-11 10.30809534388675 -0.2227597436326184 IVLLDSSLEYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVLLDSSLEYK 11 0 P49368;B4DUR8;P49368-2;Q5SZX6 P49368 CCT3 T-complex protein 1 subunit gamma 0 142305000.0 24449000.0 87531000.0 30325000.0 False True 37090920.461320914 71910409.16717549 24331250.45808033 1.0 1.938760437130833 0.6559893945865646 25.144562734924 -6.710532726753832 1.7933646867946562 1.5768111749234814 0.658961246077277 0.4676333304108694 0.39555468744166905 0.373991300421747 2.345024631767104 0.1755051691579602 0.4455680030116189 1.9474542917834044e-07 6.710532726753832 -0.9178499288462044 IVLLDSSLEYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVLLDSSLEYK 11 0 P49368;B4DUR8;P49368-2;Q5SZX6 P49368 CCT3 T-complex protein 1 subunit gamma 0 50893000.0 16785000.0 13537000.0 20571000.0 False True 22990868.097569373 12938890.579127276 15712553.473043663 1.0 0.5627839072546893 0.6834258457037042 24.454557605100764 -10.32444306082123 8.470223140407608 1.0000007146649768 0.6231048764792015 0.9286385670110824 0.049251865130056936 6.647038040655566e-07 5.297958882904681e-08 0.0476880039475578 0.01589597111819703 4.7375841729201856e-11 10.32444306082123 -0.3768958381857752 IVLLDSSLEYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVLLDSSLEYK 11 0 P49368;B4DUR8;P49368-2;Q5SZX6 P49368 CCT3 T-complex protein 1 subunit gamma 0 41263600.0 21261000.0 8235600.0 11767000.0 False True 17679463.522000033 8191233.188161388 14227425.295539184 1.0 0.4633191034314108 0.8047430442578085 24.075571161458246 -10.454586326141046 6.8442765605360085 1.000067683403278 0.634031073844617 0.6050445364404267 0.13938574016581198 0.0001439825545517236 1.1473747590371026e-05 0.13498446741252648 0.04498655419674865 3.5108613103621874e-11 10.454586326141046 -0.366036609558661 IVLLDSSLEYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVLLDSSLEYK 11 0 P49368;B4DUR8;P49368-2;Q5SZX6 P49368 CCT3 T-complex protein 1 subunit gamma 0 91312000.0 24449000.0 41362000.0 25501000.0 False True 31649712.461840298 39060168.339879826 20860079.66235613 1.0 1.2341397536225402 0.6590922330655261 24.91568905701645 -6.796172544289515 1.4716147742817867 1.12981770315761 0.6518951084003053 0.8207047973119854 0.09997546473817825 0.22626442300522845 0.9677673639361303 0.053456888402694615 0.12461511719398252 1.5989226537796103e-07 6.796172544289515 -0.4779225947573047 IVLLGK(ub)IYAGTPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVLLGKIYAGTPR 13 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 9743900.0 4494300.0 3347000.0 1902600.0 True False 6818181.677341184 2749701.6997696427 1526550.2760607975 1.0 0.4032895909634833 0.2238940451138126 22.700955611381545 -13.999999999999998 0.16840724809295185 3.9968871206639416 0.06293327918391896 0.9995168082678685 0.007292636469702977 12.076432863737029 0.12991971460096055 11.821513964591562 0.1484076013168711 1.0000000000000041e-14 13.999999999999998 -3.933953841480023 IVLPGNFLYCTFYGRPYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVLPGNFLYCTFYGRPYK 18 1 Q8NB90;Q8NB90-3;Q8NB90-2 Q8NB90 SPATA5 Spermatogenesis-associated protein 5 0 37700800.0 15203000.0 9446800.0 13051000.0 False True 23064062.488177888 7760944.731814721 10471464.129543496 1.0 0.33649513115015206 0.4540164654388588 24.459143314900587 -9.985734685439265 5.987357753267147 1.0000005114491035 0.39525579829793867 0.9724563563967629 0.047977883816715264 3.2761310869976653e-07 5.537935371427322e-08 0.04645442570638703 0.015484795417321073 1.0333925221208953e-10 9.985734685439265 -0.6047447131511648 IVLPGNFLYCTFYGRPYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVLPGNFLYCTFYGRPYK 18 1 Q8NB90;Q8NB90-3;Q8NB90-2 Q8NB90 SPATA5 Spermatogenesis-associated protein 5 0 37051000.0 15203000.0 11670000.0 10178000.0 False True 19680583.195932653 11020554.241245538 8325708.435099052 1.0 0.5599709181140087 0.4230417540075596 24.230269636993036 -13.999999999999998 0.16345232533477919 3.1836408572939963 0.2934325808081258 0.9995277164749716 0.005349092643074249 12.034432503759247 0.12787003885872175 8.329915907474431 0.11865983366000589 1.0000000000000041e-14 13.999999999999998 -2.8902082764858705 IVLQK(ub)YHTINGHNAEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVLQKYHTINGHNAEVR 17 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 61652000.0 24639000.0 25550000.0 11463000.0 True False 32301967.604415387 21738039.593119964 10276918.720860349 1.0 0.6729633271673695 0.318151477542055 24.94511871045196 -7.24484307298295 0.2961019589337337 1.0768716357468142 8.491290386946401e-17 0.9999037624560565 0.0027315153694314654 0.09657556667224039 0.01786067257262788 0.01142877572865825 0.04387582360299964 5.690585160567871e-08 7.24484307298295 -1.0768716357468142 down IVLQK(ub)YHTINGHNAEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVLQKYHTINGHNAEVR 17 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 89056000.0 32557000.0 20329000.0 36170000.0 True False 31523495.855800807 28446475.714334525 26695991.9232591 1.0 0.9023896284999094 0.84686013395772 24.909924198186207 -13.9999977979464 0.06479000983228476 1.591546637984423 0.6217621333444737 0.9999409729587359 0.00048630120523466386 12.414545688554325 0.06690762837371413 1.1490338194100318 0.2091553975512871 1.0000050704286497e-14 13.9999977979464 -0.9697845046399493 IVLQK(ub)YHTINGHNAEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVLQKYHTINGHNAEVR 17 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 297461000.0 47611000.0 45225000.0 204625000.0 True False 72229367.83033863 37154245.405462205 164180779.05967635 1.0 0.5143925043444204 2.2730474319715035 26.10608220781466 -6.833071111879701 1.3141776365202762 0.7410297351456833 2.323394471362499 0.9118716715609577 0.22014548645402188 0.17705077896823943 0.5969343553309813 0.1314846393496581 0.30258014325277016 1.468685773650564e-07 6.833071111879701 1.582364736216816 up IVLQK(ub)YHTINGHNAEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVLQKYHTINGHNAEVR 17 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 61894000.0 24639000.0 15690000.0 21565000.0 True False 33748704.14393871 14996763.920108395 16471791.14511628 1.0 0.4443656223405491 0.48807181084239126 25.008328771974853 -9.827359899817404 6.6953023041510695 1.000000007519426 0.4662187182672178 0.994996865166089 0.01784297673869539 2.017097710886717e-09 3.460552065184409e-10 0.01727638819631518 0.00575879597962573 1.4881273555169107e-10 9.827359899817404 -0.5337812892522082 IVLQK(ub)YHTINGHNAEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVLQKYHTINGHNAEVR 17 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 99319000.0 32557000.0 39220000.0 27542000.0 True False 27072588.019648917 39008714.07543948 33300904.860180207 1.0 1.4408934250071508 1.230059898078856 24.690329473620483 -10.124997876407116 4.460270408615284 0.9999580322920425 1.3354766614257427 0.7714733241586131 0.08607242698650236 60062136.32635767 2.66353439335869 25887.753249346995 0.029464881143053765 7.498978761391187e-11 10.124997876407116 0.33551862913370023 IVLQK(ub)YHTINGHNAEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVLQKYHTINGHNAEVR 17 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 294985000.0 47611000.0 55597000.0 191777000.0 True False 61633378.05311783 52502978.07630925 156875553.79819107 1.0 0.8518594913142733 2.5453018924744018 25.877208529907108 -6.8855877126874985 1.048108048506314 0.8991544080506739 2.678971951398697 0.9779215258225842 0.11378462830208565 0.12279713837928959 0.24333316229804214 0.08315903805222076 0.2042872392748882 1.3014044496794888e-07 6.8855877126874985 1.779817543348023 up IVLQVFHSLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVLQVFHSLLK 11 0 H0Y4W2;F2Z2U4;Q9Y4A5-2;Q9Y4A5 H0Y4W2 TRRAP Transformation/transcription domain-associated protein 0 3178240.0 836050.0 1416000.0 926190.0 False True 1096069.6463197167 1204738.3195247704 830356.7434418256 1.0 1.0991439490820054 0.7575766250164141 20.063908042082204 -6.82905096965962 1.3322209257764868 1.0530109959070015 0.7485669743949487 0.9039498383322945 0.04446585561334125 0.18198484160976186 0.6320288154543875 0.026209588260287995 0.06031591408609495 1.482344104099994e-07 6.82905096965962 -0.30444402151205285 IVLQVFHSLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVLQVFHSLLK 11 0 H0Y4W2;F2Z2U4;Q9Y4A5-2;Q9Y4A5 H0Y4W2 TRRAP Transformation/transcription domain-associated protein 0 8972250.0 836050.0 1628400.0 6507800.0 False True 1145160.2784017199 1556451.9036013065 4970791.672348142 1.0 1.359156384443948 4.34069515516709 20.127118103605095 -6.929414070633963 0.7515877637070673 0.9536606555325453 4.943752386718649 0.9964218106360284 0.08956909569473882 0.09294318740616443 0.07917944792726186 0.08131918326038913 0.2706522234545586 1.1764837403506826e-07 6.929414070633963 3.9900917311861037 up IVLVDNK(ub)CK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVLVDNKCK 9 1 D6RD17;D6RHJ6;P01591;C9JA05 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 1 7157030.0 629130.0 3811600.0 2716300.0 True False 824795.5225035858 3242924.137500432 2435243.3325894624 1.0 3.9317916368615267 2.952541892077106 19.65367697532978 -10.410811275541832 5.859839534146143 0.9991385932209611 3.4421667644691407 0.8923900822754173 0.3997770342454217 0.00450011030430332 0.00045247329515044033 0.387166158724272 0.12902748298572464 3.883190749868856e-11 10.410811275541832 2.4430281712481796 IVLVDNK(ub)CK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVLVDNKCK 9 1 D6RD17;D6RHJ6;P01591;C9JA05 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 1 29931300.0 5295800.0 7048500.0 17587000.0 True False 5127687.72777436 9863002.807441924 12980437.10130932 1.0 1.9234796132413656 2.5314406396084097 22.289876974941315 -8.326016874236956 0.15599605887680448 9.174827853682165e-10 3.61920403719823 0.9999019718829627 0.006233767319182548 0.09846644535759357 0.03512813494729601 0.36600469790067464 0.3571822184176232 4.7204469990951145e-09 8.326016874236956 3.619204036280747 IVLVDNK(ub)CK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVLVDNKCK 9 1 D6RD17;D6RHJ6;P01591;C9JA05 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 1 29368900.0 5295800.0 1858600.0 22214500.0 True False 4403692.343718914 1848587.352896784 26859449.241757058 1.0 0.4197812218951821 6.099301936945549 22.07028225037559 -6.881719997509721 1.0702027704511223 0.6315565217608297 6.515251529413389 0.9750447669232919 0.4030838148068762 0.12611547055842032 0.263194961950798 0.28968167004685835 0.7036626074138898 1.3130461858666414e-07 6.881719997509721 5.883695007652559 up IVLVDNK(ub)CK(ub)CAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVLVDNKCKCAR 12 2 D6RD17;D6RHJ6;P01591;C9JA05 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 2 3158340.0 471280.0 818160.0 1868900.0 True False 617852.643882012 696093.7171627007 1675524.1557546828 1.0 1.1266338730689804 2.71185075008702 19.23690327488086 -6.922793294737832 0.803741839127486 0.9684184966579424 2.98465693645983 0.9949222776162903 0.05549897320046506 0.09655586747109854 0.0973021759302163 0.04853953784132778 0.1495187161731982 1.1945565260713944e-07 6.922793294737832 2.0162384398018873 up IVLVDNK(ub)CK(ub)CAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVLVDNKCKCAR 12 2 D6RD17;D6RHJ6;P01591;C9JA05 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 2 5792200.0 756440.0 902760.0 4133000.0 True False 732427.2262543219 1263236.775831208 3050443.312657722 1.0 1.7247266766576648 4.1648415068591556 19.48232589535364 -6.948831819770721 0.5715239794183047 0.9698090022620955 5.03870683294877 0.9991063977294949 0.04047017428156347 0.08395822892342132 0.03792994872044518 0.0428015233578375 0.20338617318255736 1.1250405607782579e-07 6.948831819770721 4.068897830686675 IVLVDNK(ub)CK(ub)CAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVLVDNKCKCAR 12 2 D6RD17;D6RHJ6;P01591;C9JA05 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 2 3815670.0 471280.0 841990.0 2502400.0 True False 645524.9518631214 804788.0977114111 1911384.6585457462 1.0 1.2467188067457697 2.960977190779514 19.30011333640375 -6.932816082270149 0.7233098408406085 0.9764596707363935 3.3395402411930286 0.9970632410554827 0.047260585265935955 0.0912018120812324 0.07071027790966908 0.043801824075943026 0.15278006867411031 1.1673038495016885e-07 6.932816082270149 2.363080570456635 up IVNQPSSLFGSK(ub)SASSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVNQPSSLFGSKSASSK 17 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 21476000.0 7966200.0 8690000.0 4819800.0 True False 10911519.418460347 8306047.06601287 3681462.506896895 1.0 0.7612181903796568 0.337392288434965 23.379348673741962 -6.9623105879269795 0.40154669350829714 1.022904493523268 0.060191784775614356 0.9998465243153173 0.003394477849760992 0.07888585768051154 0.018155885037672896 0.0054525708726147195 0.035489398745291535 1.0906600663326068e-07 6.9623105879269795 -0.9627127087476537 down IVNQPSSLFGSK(ub)SASSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVNQPSSLFGSKSASSK 17 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 27220400.0 7996600.0 15384000.0 3839800.0 True False 6649527.209445721 15301123.338515088 4642684.426770748 1.0 2.301084401426268 0.698197673388834 22.66482033597765 -6.690803297387274 1.8636226680782797 1.81507941543883 0.7036905549077457 0.3741889084286475 0.5501767653712007 0.4149287034007216 2.79464868173431 0.23612018276148872 0.6142376373519757 2.0379649129495878e-07 6.690803297387274 -1.1113888605310842 IVNSAQTGSFK(ub)QLTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVNSAQTGSFKQLTVK 16 1 E9PN17;A0A3B3ITX4;O75964 E9PN17 ATP5L ATP synthase subunit g, mitochondrial 1 8913900.0 2485900.0 2253500.0 4174500.0 True False 2406986.4652128657 3153334.3018472553 3081073.217684414 1.0 1.310075626689652 1.2800542347095973 21.19879659870402 -10.131976391999979 4.725142159543841 0.999976644854027 1.2950649307025857 0.9922957749288508 0.012256181963365016 3.0157043370064672e-06 5.5399501326898e-07 0.011867935771833786 0.003955665717909783 7.37944343271905e-11 10.131976391999979 0.2950882858485586 IVNSAQTGSFK(ub)QLTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVNSAQTGSFKQLTVK 16 1 E9PN17;A0A3B3ITX4;O75964 E9PN17 ATP5L ATP synthase subunit g, mitochondrial 1 28109600.0 4856900.0 9025700.0 14227000.0 True False 7368272.38695201 7414993.316884033 11415027.214084394 1.0 1.0063408255664867 1.5492135217881626 22.812894964635234 -6.909450984442124 0.8994673130398186 0.9828981800797696 1.6185525451705374 0.9907126292687437 0.024807843479025985 0.10478231390611965 0.1407457548121303 0.020255510485023068 0.05570382459237399 1.231825004732031e-07 6.909450984442124 0.6356543650907678 IVNSAQTGSFK(ub)QLTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVNSAQTGSFKQLTVK 16 1 E9PN17;A0A3B3ITX4;O75964 E9PN17 ATP5L ATP synthase subunit g, mitochondrial 1 8494200.0 2485900.0 2388700.0 3619600.0 True False 2067135.9940426107 2375831.5989801725 4376441.624860507 1.0 1.1493349280488598 2.1171522519433688 20.979201874138298 -6.934226354487419 0.7112479358926945 0.9873359996754089 2.3390614718746665 0.9973056160554518 0.025704531099317265 0.0905018883286169 0.06736028937082042 0.02403751713145022 0.08562712614893037 1.1635194444685224e-07 6.934226354487419 1.3517254721992575 up IVNSAQTGSFK(ub)QLTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVNSAQTGSFKQLTVK 16 1 E9PN17;A0A3B3ITX4;O75964 E9PN17 ATP5L ATP synthase subunit g, mitochondrial 1 31672900.0 4856900.0 9104000.0 17712000.0 True False 6287352.79381211 8597354.39694083 14488597.74046713 1.0 1.3674044830762762 2.3044034931086617 22.584021286727683 -6.955033157723985 0.5005493580837782 0.981323851828131 2.730935416978916 0.999539355235201 0.011786922285685963 0.08152544878745889 0.02806887549162856 0.013808779621008656 0.07729540639247032 1.109090134682788e-07 6.955033157723985 1.749611565150785 up IVPNVLLEQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVPNVLLEQGK 11 0 O75390;B4DJV2;A0A0C4DGI3;H0YIC4 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 0 12967100.0 0.0 6569900.0 6397200.0 False True 0.0 6279620.094246013 4886313.114469645 0.0 IVPVEITISLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVPVEITISLLK 12 0 P30085;P30085-3;Q5T0D2 P30085 CMPK1 UMP-CMP kinase 0 316776000.0 183730000.0 73288000.0 59758000.0 False True 177897591.7187175 102552280.59187117 44105587.098427355 1.0 0.5764680657061483 0.24792683628997542 27.40647173941178 -7.924286415444529 0.27729447099835813 1.1394158351631787 3.8008757751899683e-22 0.9994692309429678 0.007092327432518201 0.10823345688335409 0.04853035643705635 0.05534576157888045 0.0896744063386225 1.1904566477673049e-08 7.924286415444529 -1.1394158351631787 down IVPVEITISLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVPVEITISLLK 12 0 P30085;P30085-3;Q5T0D2 P30085 CMPK1 UMP-CMP kinase 0 871560800.0 258220800.0 334250000.0 279090000.0 False True 391739832.06915015 274600475.99282986 223927739.17050725 1.0 0.7009766521377311 0.5716236155709062 28.54532058794152 -13.999999999999998 0.11416966336703765 2.4336738903030057 0.3479642783465166 0.9997219607870278 0.0029913714901261467 11.989786114080916 0.10318993270235252 3.933726013933134 0.19850326928772175 1.0000000000000041e-14 13.999999999999998 -2.085709611956489 IVPVEITISLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVPVEITISLLK 12 0 P30085;P30085-3;Q5T0D2 P30085 CMPK1 UMP-CMP kinase 0 15890600.0 2439900.0 2342700.0 11108000.0 False True 3341996.9658182617 2239191.7677270817 8484519.17644106 1.0 0.6700160983476037 2.5387572948809343 21.672278992908513 -6.861286670815893 1.1791274338813198 0.8203005686552828 2.631538860979719 0.9551909721749261 0.17238802524783964 0.14548715065203682 0.38362197654167446 0.1139625702018789 0.2664358448662088 1.3763006949980254e-07 6.861286670815893 1.8112382923244361 up IVPVEITISLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVPVEITISLLK 12 0 P30085;P30085-3;Q5T0D2 P30085 CMPK1 UMP-CMP kinase 0 227092000.0 183730000.0 16650000.0 26712000.0 False True 152779635.6190711 16560303.145233758 32297355.697666604 1.0 0.10839339338734866 0.21139830296620374 27.186877014846058 -10.364129933577376 5.728417312237807 1.0001913392354054 0.15989584817678007 0.9888508527240611 0.04205157824496221 0.00010278243530232199 1.1409094407619807e-05 0.0407252759085506 0.013572088518704964 4.323844495536552e-11 10.364129933577376 -0.8402954910586253 IVPVEITISLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVPVEITISLLK 12 0 P30085;P30085-3;Q5T0D2 P30085 CMPK1 UMP-CMP kinase 0 486787800.0 258220800.0 1057000.0 227510000.0 False True 334271915.892935 998177.0208223258 186105514.44973326 1.0 0.002986122893859965 0.5567488789855191 28.31644691003397 -10.163454462270154 5.888125370155717 1.0000085452957692 0.2798675009396749 0.6927654026506518 0.22607269849703063 2.5360619643228307e-05 3.6030282201031842e-06 0.2188965457245489 0.07296464969258967 6.863498415066029e-11 10.163454462270154 -0.7201410443560943 IVQAEGEAEAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVQAEGEAEAAK 12 0 Q99623;J3KPX7;F5GY37 Q99623 PHB2 Prohibitin-2 0 20480000.0 3108600.0 8821100.0 8550300.0 False True 4075404.7037252183 7505026.264378491 7665596.976269069 1.0 1.8415413461927712 1.880941288913504 21.958511901076832 -11.10725271893949 0.5262026624308611 1.5703610339012954e-20 1.8782862245980612 0.9998468136082117 0.0050288535101116316 3.0936516320625707 0.25710872192238254 3.6932760391669492 0.007647089728143341 7.81173102314712e-12 11.10725271893949 1.8782862245980612 IVQAEGEAEAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVQAEGEAEAAK 12 0 Q99623;J3KPX7;F5GY37 Q99623 PHB2 Prohibitin-2 0 18236200.0 3108600.0 6755000.0 8372600.0 False True 4257933.426756275 6456541.764202165 6395164.319109697 1.0 1.516355733424608 1.5019408896633644 22.021721962599724 -10.2140220665196 5.066111061562309 0.9999469149820608 1.5091483115443278 0.9993991972094518 0.005884835324094437 3.5289697088602397e-06 5.475181591474206e-07 0.005698559217774044 0.001899322433601488 6.109109837060161e-11 10.2140220665196 0.509201396562267 IVQAEGEAEAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVQAEGEAEAAK 12 0 Q99623;J3KPX7;F5GY37 Q99623 PHB2 Prohibitin-2 0 877390.0 0.0 0.0 877390.0 False True 0.0 0.0 1060848.1924069962 0.0 IVQAEGEAEAAK(ub)MLGEALSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVQAEGEAEAAKMLGEALSK 20 1 Q99623;J3KPX7;F5GY37 Q99623 PHB2 Prohibitin-2 1 4222200.0 862900.0 1887000.0 1472300.0 True False 1131270.2563354862 1605466.9554683885 1319960.5192988496 1.0 1.41917189679234 1.166795035851633 20.109512194406747 -10.323278205253121 4.911405994592633 0.9998609446721014 1.292983466322121 0.6424623456549003 0.1030324220321446 0.00015695452878194925 2.1626173505677473e-05 0.09980781168523928 0.03325357122075952 4.7503082785518206e-11 10.323278205253121 0.2931225216500195 IVQAEGEAEAAK(ub)MLGEALSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVQAEGEAEAAKMLGEALSK 20 1 Q99623;J3KPX7;F5GY37 Q99623 PHB2 Prohibitin-2 1 16454300.0 5773300.0 3193400.0 7487600.0 True False 5590029.751644651 4468541.273360999 5526372.936814903 1.0 0.7993770108372505 0.988612437203752 22.414424530824835 -10.543379493565777 7.78442984824639 1.0000295663137684 0.8939947240321358 0.2949788871886777 0.07725503930932447 3.965279316105696e-05 2.325948854098466e-06 0.07482271276097317 0.02493395672130107 2.8616762978781757e-11 10.543379493565777 -0.10603484228163262 IVQAEGEAEAAK(ub)MLGEALSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVQAEGEAEAAKMLGEALSK 20 1 Q99623;J3KPX7;F5GY37 Q99623 PHB2 Prohibitin-2 1 39998300.0 5903500.0 9527800.0 24567000.0 True False 8956041.103660999 7827489.648958819 19711321.68190139 1.0 0.8739899201399537 2.2008967415127105 23.094429718764328 -6.883619493833716 1.0593570881762768 0.9174228141942858 2.301732123826895 0.9764916686506794 0.0916918613810355 0.12447440609522027 0.25329506501701177 0.06644002132216564 0.1622603726475474 1.307315788393926e-07 6.883619493833716 1.384309309632609 up IVQAEGEAEAAK(ub)MLGEALSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVQAEGEAEAAKMLGEALSK 20 1 Q99623;J3KPX7;F5GY37 Q99623 PHB2 Prohibitin-2 1 6396800.0 862900.0 2346400.0 3187500.0 True False 1181937.4489956864 2242728.289492815 2434678.148623148 1.0 1.897501675235438 2.0599043973874744 20.17272225592964 -10.879925913241596 0.3271382550883428 3.6050247135891194e-10 2.09657513474907 0.999259958137447 0.012679772454884714 2.6370031204111566 0.1633364118629481 2.0798035724777835 0.05239415515531645 1.3184816405606162e-11 10.879925913241596 2.096575134388568 IVQAEGEAEAAK(ub)MLGEALSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVQAEGEAEAAKMLGEALSK 20 1 Q99623;J3KPX7;F5GY37 Q99623 PHB2 Prohibitin-2 1 13856900.0 5773300.0 5033100.0 3050500.0 True False 4800754.750555616 5005985.691307869 3688345.4460816076 1.0 1.0427497240363093 0.7682844964439678 22.19482980625911 -6.867104645894155 1.1492336898362308 1.023804277214484 0.753066170517817 0.9617107610297072 0.023594199596831688 0.1396649306100899 0.3465597723566686 0.015958995926972863 0.03760683376109613 1.3579861921377455e-07 6.867104645894155 -0.270738106696667 IVQAEGEAEAAK(ub)MLGEALSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVQAEGEAEAAKMLGEALSK 20 1 Q99623;J3KPX7;F5GY37 Q99623 PHB2 Prohibitin-2 1 33167500.0 5903500.0 6119000.0 21145000.0 True False 7642197.125382387 5778472.270966702 17296826.966021735 1.0 0.7561270896525806 2.263331694045548 22.865556040856777 -6.865420820688097 1.1579690188679963 0.8652289009289437 2.3442748720813595 0.9598995490883919 0.13227931415504116 0.1413252881694559 0.35705382806436065 0.08887569281912525 0.20891029718073664 1.3632615294451556e-07 6.865420820688097 1.479045971152416 up IVQLLGQNEVDYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVQLLGQNEVDYR 13 0 Q9BZX2;A0A2R8Y653 Q9BZX2 UCK2 Uridine-cytidine kinase 2 0 4507100.0 1528500.0 2978600.0 0.0 False True 2003878.3020150557 2534204.490491861 0.0 1.0 1.2646498981218177 0.0 20.93436346387993 -6.893567731585441 1.3115818914588384 1.1378236187237292 9.334720895150085e-19 0.9420064120512619 0.13115167710190181 0.1389088530287709 0.4799122284830093 0.0814859023274417 0.16355003349299724 1.2777099252757332e-07 6.893567731585441 -1.1378236187237292 down IVQLLGQNEVDYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVQLLGQNEVDYR 13 0 Q9BZX2;A0A2R8Y653 Q9BZX2 UCK2 Uridine-cytidine kinase 2 0 6891100.0 1528500.0 2520500.0 2842100.0 False True 2093627.7561593554 2409135.975821107 2170854.514886851 1.0 1.1506992915686856 1.036886575705876 20.99757352540282 -10.10072314581113 5.181047334529423 0.9999979443498085 1.093792933637424 0.4752084930374566 0.046463846684541565 1.1033746487200661e-06 1.9150675404759534e-07 0.044989411555477234 0.01499614203409173 7.930066955517756e-11 10.10072314581113 0.09379498928761543 IVQQK(ub)ALPLTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVQQKALPLTR 11 1 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 52689690.0 975690.0 16919000.0 34795000.0 True False 1480193.0624936062 13899672.261249632 27917752.998809732 1.0 9.39044548542442 18.86088626288932 20.49735392905467 -7.354379949909922 0.3527753999869564 5.65390622940865e-18 24.89776423229697 0.9993682412328733 0.1833865610222853 0.13648715190256436 0.037298973446057655 0.4149976657353367 1.6211775766843324 4.422013357291262e-08 7.354379949909922 24.89776423229697 IVQQK(ub)ALPLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVQQKALPLTR 11 1 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 45861690.0 975690.0 13056000.0 31830000.0 True False 1263049.9387252217 12329422.122853616 26037266.603380095 1.0 9.76162679307639 20.614597891243427 20.268480251147118 -7.232774410325512 0.3569469343317169 1.595256752401581e-20 27.874860025866052 0.9996088907335536 0.15866244420441988 0.11848763731067166 0.028924973187058327 0.3314088434962103 1.5172527902285091 5.850939260744577e-08 7.232774410325512 27.874860025866052 IVQSLLSLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVQSLLSLLK 10 0 Q86VV8-3;Q86VV8;J3KT00;A0A1W2PPP3;Q86VV8-4;J3KTD2;A0A1W2PQI7;Q86VV8-2 Q86VV8-3 RTTN Rotatin 0 2112660.0 240430.0 743630.0 1128600.0 False True 329323.4683764433 710773.9677444353 862047.9242466136 1.0 2.1582851998022905 2.6176328352682816 18.329145799925776 -9.832357443491867 0.23883457783333337 7.950243890844181e-16 2.9110891627073148 0.999166119444817 0.01965465349372526 1.270304684644321 0.10422590951752864 1.0938805474659654 0.21684444465647829 1.4711012229156543e-10 9.832357443491867 2.911089162707314 IVQVALNGLENILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVQVALNGLENILR 14 0 O60684;O15131;P52294 O60684;P52294 KPNA6;KPNA5;KPNA1 Importin subunit alpha-7;Importin subunit alpha-6;Importin subunit alpha-5;Importin subunit alpha-5, N-terminally processed 0 8477790.0 4661500.0 3253900.0 562390.0 False True 6111271.642030209 2768430.8036028566 504199.2776258095 1.0 0.45300404985486187 0.08250316908811318 22.543041178626005 -8.259101678728483 0.4088773855407348 1.0739948598542686 4.866148447284608e-23 0.9967760712883421 0.0213985204538008 0.11396854091462401 0.11000673986599592 0.0677533818980802 0.08127320795458658 5.506787542406998e-09 8.259101678728483 -1.0739948598542686 IVQVALNGLENILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVQVALNGLENILR 14 0 O60684;O15131;P52294 O60684;P52294 KPNA6;KPNA5;KPNA1 Importin subunit alpha-7;Importin subunit alpha-6;Importin subunit alpha-5;Importin subunit alpha-5, N-terminally processed 0 60696000.0 32000000.0 17840000.0 10856000.0 False True 30984177.51591441 24963605.034370966 8012487.926980942 1.0 0.8056888075066347 0.2585993422889953 24.88502833626608 -6.9528679361633845 0.5264169920221285 1.0088564655833479 0.030747683651309615 0.9994075595302551 0.007640095746251513 0.08235414370552072 0.03135132500775596 0.008569437382872034 0.04522132249127767 1.1146334289591264e-07 6.9528679361633845 -0.9781087819320382 down IVQVALNGLENILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVQVALNGLENILR 14 0 O60684;O15131;P52294 O60684;P52294 KPNA6;KPNA5;KPNA1 Importin subunit alpha-7;Importin subunit alpha-6;Importin subunit alpha-5;Importin subunit alpha-5, N-terminally processed 0 318426000.0 90576000.0 119760000.0 108090000.0 False True 137410413.99258065 98387892.3108491 86725964.12247 1.0 0.7160148161416752 0.6311454976560416 27.033916105657486 -13.999999999999998 0.16926371725067432 2.4294058257273976 0.5556912204064632 0.999515101376705 0.0034732382573598336 12.084469806229087 0.1302680499999844 5.671244822626082 0.06965966430036512 1.0000000000000041e-14 13.999999999999998 -1.8737146053209344 IVQVALNGLENILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVQVALNGLENILR 14 0 O60684;O15131;P52294 O60684;P52294 KPNA6;KPNA5;KPNA1 Importin subunit alpha-7;Importin subunit alpha-6;Importin subunit alpha-5;Importin subunit alpha-5, N-terminally processed 0 16041000.0 4661500.0 2417600.0 8961900.0 False True 6384982.522300836 2310782.438065905 6845283.796124164 1.0 0.36190896842630854 1.0720912347395837 22.606251240148897 -6.6699394078200624 1.9377056621491169 0.5926815114673792 1.0692110956311651 0.278704234063875 0.27105216517098185 0.461271225737208 3.3389924212147184 0.11261898758060927 0.3009005421498253 2.13826039589647e-07 6.6699394078200624 0.4765295841637859 IVQVALNGLENILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVQVALNGLENILR 14 0 O60684;O15131;P52294 O60684;P52294 KPNA6;KPNA5;KPNA1 Importin subunit alpha-7;Importin subunit alpha-6;Importin subunit alpha-5;Importin subunit alpha-5, N-terminally processed 0 60810000.0 32000000.0 11227000.0 17583000.0 False True 26609417.840365056 11166517.922614971 21259524.005393498 1.0 0.4196453296951113 0.7989473551407029 24.665433611700355 -10.147104550026329 5.567773489650713 1.00000696816758 0.6092963424178842 0.5858693287198504 0.15484940345782053 1.3394101930099815e-05 2.0521539783015867e-06 0.14993496329335085 0.04997743006349863 7.12681441870082e-11 10.147104550026329 -0.39071062574969584 IVQVALNGLENILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVQVALNGLENILR 14 0 O60684;O15131;P52294 O60684;P52294 KPNA6;KPNA5;KPNA1 Importin subunit alpha-7;Importin subunit alpha-6;Importin subunit alpha-5;Importin subunit alpha-5, N-terminally processed 0 206715000.0 90576000.0 54155000.0 61984000.0 False True 117252417.51988417 51141226.643929094 50703548.009548 1.0 0.4361635156499553 0.4324307257967579 26.805042427749935 IVQYECEGDTCQEEK(ub)IDALQLEYSYLLTSQLESQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVQYECEGDTCQEEKIDALQLEYSYLLTSQLESQR 35 1 J3KNN7;Q7Z569;Q7Z569-2 J3KNN7 BRAP BRCA1-associated protein 1 415156100.0 145293400.0 190267700.0 79595000.0 True False 220420710.17035004 156312942.36667463 63863013.362272196 1.0 0.7091572395618799 0.28973236368268784 27.71568454133993 -7.092162683500561 0.3667547294540502 1.0366101895797446 2.786491881134471e-17 0.999887650216265 0.0030902320576104247 0.07560975481046094 0.016801803753994572 0.006404178579037124 0.03528715903775157 8.08792874598142e-08 7.092162683500561 -1.0366101895797446 down IVQYECEGDTCQEEK(ub)IDALQLEYSYLLTSQLESQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVQYECEGDTCQEEKIDALQLEYSYLLTSQLESQR 35 1 J3KNN7;Q7Z569;Q7Z569-2 J3KNN7 BRAP BRCA1-associated protein 1 195295400.0 145293400.0 12638000.0 37364000.0 True False 188085170.46108842 11934684.190305151 30564135.387015175 1.0 0.06345361604557884 0.1625015694330796 27.48681086343238 -10.187609447945936 5.095041629968594 1.0000641857535664 0.1129775927385927 0.9907351017633678 0.040436157647139634 2.9574761427024786e-05 4.71557698842463e-06 0.03915496021729425 0.013050713762270329 6.49217999447115e-11 10.187609447945936 -0.8870865930149736 IVSGIITPIHEQWEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVSGIITPIHEQWEK 15 0 Q5QPM9;Q5QPM7;Q92530 Q5QPM9 PSMF1 Proteasome inhibitor PI31 subunit 0 4918500.0 1026900.0 3891600.0 0.0 False True 1346275.8445137471 3310988.4493379886 0.0 1.0 2.4593685334478117 0.0 20.360542609836592 -6.747420982175792 1.668942323619639 1.8622440439254786 9.315967433953364e-09 0.6312693233034171 0.6132157831170632 0.30600330942489545 1.6778091388943372 0.2908485288016547 0.7053955947864787 1.7888709761022947e-07 6.747420982175792 -1.8622440346095113 IVSGIITPIHEQWEK(ub)ANVSSPHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVSGIITPIHEQWEKANVSSPHR 23 1 Q5QPM9;Q5QPM7;Q92530 Q5QPM9 PSMF1 Proteasome inhibitor PI31 subunit 1 46249000.0 4378900.0 19169100.0 22701000.0 True False 4239894.21638868 26823421.5955359 16754927.084597863 1.0 6.32643651623523 3.9517323379989495 22.015596839915652 -9.803037609662756 10.056325543891282 1.0000000034441727 5.13908442711709 0.8020069821466069 0.969468921122354 0.0 0.0 0.9386842465431375 0.31289474884771246 1.5738465643195586e-10 9.803037609662756 4.139084423672917 IVSGIITPIHEQWEK(ub)ANVSSPHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVSGIITPIHEQWEKANVSSPHR 23 1 Q5QPM9;Q5QPM7;Q92530 Q5QPM9 PSMF1 Proteasome inhibitor PI31 subunit 1 153966800.0 8212800.0 105480000.0 40274000.0 True False 12459418.036105204 86656269.8809985 32313826.2472787 1.0 6.955081660305791 2.593526130485301 23.57073334765909 -6.566080621246995 2.3220187669889185 5.088533194566613 2.601677590299556 0.0 2.596126293027251 0.7420919785747895 7.505934082532993 0.9472400174502067 2.91415530752799 2.715935043240815e-07 6.566080621246995 -2.4868556042670567 IVSGIITPIHEQWEK(ub)ANVSSPHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVSGIITPIHEQWEKANVSSPHR 23 1 Q5QPM9;Q5QPM7;Q92530 Q5QPM9 PSMF1 Proteasome inhibitor PI31 subunit 1 58430200.0 4378900.0 31742600.0 22308700.0 True False 3641249.368161708 31571596.313387245 26973346.026225485 1.0 8.670539455342556 7.4077173241894805 21.79600211534993 -9.321818364576632 10.747283940101683 0.9999999100786422 8.03912838976654 0.9764305622034896 0.5155449762031962 0.0 0.0 0.49917427676396026 0.16639142558798672 4.766302866959252e-10 9.321818364576632 7.039128479687898 IVSGIITPIHEQWEK(ub)ANVSSPHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVSGIITPIHEQWEKANVSSPHR 23 1 Q5QPM9;Q5QPM7;Q92530 Q5QPM9 PSMF1 Proteasome inhibitor PI31 subunit 1 248148900.0 8212800.0 207487000.0 32449100.0 True False 10631631.498490809 195940166.05426863 26543696.755882546 1.0 18.429924521187825 2.4966720074572284 23.34185966975154 -6.461923241348481 2.816449356195367 9.999999999999998 2.446433301902335 0.184698700437413 7.121922560540916 0.6797719921436515 10.032725412409466 2.6702950253016846 9.626907977867425 3.452047465797046e-07 6.461923241348481 -7.553566698097663 IVSGK(ub)DYNVTANSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVSGKDYNVTANSK 14 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 P00338 LDHA L-lactate dehydrogenase A chain 1 19549000.0 6633000.0 7255600.0 5660400.0 True False 8695927.234063363 6173092.7621072875 5074716.106390821 1.0 0.7098832126752715 0.5835738926738406 23.05190843753034 -13.999999999999998 0.11314784765682524 2.392904832312278 0.3620216678534839 0.9997271134181221 0.0028798736150678315 11.995047860021495 0.10257355348602001 3.7957108522448215 0.1966598856660352 1.0000000000000041e-14 13.999999999999998 -2.030883164458794 IVSGK(ub)DYNVTANSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVSGKDYNVTANSK 14 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 P00338 LDHA L-lactate dehydrogenase A chain 1 40036900.0 8380900.0 12627000.0 19029000.0 True False 8114852.916972715 17669026.948935103 14044734.042236589 1.0 2.1773687249437685 1.730744128813618 22.95213351525243 -10.178131268591786 4.927906844148142 0.9999149877494518 1.954056426880773 0.8588402714693093 0.18233372785644023 127901855.15587366 19.54838421687169 123377.79546539024 0.06241768483702195 6.635424796610775e-11 10.178131268591786 0.9541414391313212 IVSGK(ub)DYNVTANSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVSGKDYNVTANSK 14 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 P00338 LDHA L-lactate dehydrogenase A chain 1 55400000.0 12710000.0 10614000.0 32076000.0 True False 19281999.22546481 8719848.772439484 25736164.540589772 1.0 0.4522274205323895 1.3347249027269568 24.200751307228206 -6.738856127262699 1.6912142388343065 0.6736423496067567 1.3350815168698973 0.5996733426070022 0.2301564592015074 0.3198803605136247 1.796075100559339 0.10768751120284942 0.26455432737096285 1.8245000211592332e-07 6.738856127262699 0.6614391672631406 IVSGK(ub)DYNVTANSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVSGKDYNVTANSK 14 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 P00338 LDHA L-lactate dehydrogenase A chain 1 22410200.0 6633000.0 7937800.0 7839400.0 True False 9085399.350085044 7587081.749205619 5987895.177510994 1.0 0.8350851136922891 0.6590679117979491 23.11511849905323 -6.970297873897047 0.2509799461293765 1.0551905382618592 0.4338008153270988 0.9999846089778794 0.0005461079017434369 0.07620622846168451 0.00868411479136987 0.003899910822101732 0.016842683642787862 1.070784623562494e-07 6.970297873897047 -0.6213897229347604 IVSGK(ub)DYNVTANSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVSGKDYNVTANSK 14 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 P00338 LDHA L-lactate dehydrogenase A chain 1 33341400.0 8380900.0 16542000.0 8418500.0 True False 6969089.686822354 16452884.962670086 10178769.42725389 1.0 2.3608370249245554 1.4605593965163952 22.732538790686707 -10.498401270617201 5.635838380760184 0.9986434236720075 1.9106982107204247 0.5770558280362124 0.3675368027404954 0.006272159516908215 0.0005582314090481473 0.3562848306410928 0.11862199301102118 3.1739401225386136e-11 10.498401270617201 0.9120547870484171 IVSGK(ub)DYNVTANSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVSGKDYNVTANSK 14 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 P00338 LDHA L-lactate dehydrogenase A chain 1 37678000.0 12710000.0 10645000.0 14323000.0 True False 16453345.55155591 10052596.392292954 11716360.966390615 1.0 0.610975826210757 0.7120959642935755 23.971877629320655 -10.017966750767357 7.034150493258508 1.0000000418545762 0.6615358952521684 0.9372563557171452 0.041282123503781284 2.708174754223989e-08 3.768046424363214e-09 0.03997124926928964 0.013323748068851757 9.594740852604522e-11 10.017966750767357 -0.33846414660240787 IVSLFAEHNDLQYAAPGGLIGVGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVSLFAEHNDLQYAAPGGLIGVGTK 25 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 63546000.0 25341000.0 20590000.0 17615000.0 False True 24536563.825962104 28811694.37543155 13001103.06132733 1.0 1.174235095826496 0.5298664944914121 24.548429888014756 -6.8346965880009485 1.306767652467841 1.0928415686349613 0.5107994275014826 0.9149504740671963 0.07936800845103013 0.17508503507433457 0.5830447626528413 0.047662246335077964 0.10969887867730034 1.463199055059234e-07 6.8346965880009485 -0.5820421411334787 IVSLFAEHNDLQYAAPGGLIGVGTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVSLFAEHNDLQYAAPGGLIGVGTK 25 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 129610000.0 29523000.0 63215000.0 36872000.0 False True 44788549.42040894 51933789.34895061 29584233.03842828 1.0 1.1595327381887874 0.6605311719460943 25.416626606183865 -6.820688216571618 1.3688718324808897 1.085927777430352 0.6494736596514474 0.8859654828103041 0.07026804071066958 0.19258718380746825 0.7089020733465119 0.04033657630977874 0.09295368211882486 1.511164641832391e-07 6.820688216571618 -0.4364541177789045 IVSLFAEHNDLQYAAPGGLIGVGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVSLFAEHNDLQYAAPGGLIGVGTK 25 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 22831000.0 5643000.0 4342000.0 12846000.0 False True 7729369.596341007 4150156.0829260997 9812039.371674635 1.0 0.5369333205247081 1.2694488534122548 22.8819193227602 -6.735884021827706 1.7019049984648853 0.7231649036697888 1.2694910749755655 0.5862308918479661 0.1945894209340219 0.3253319484011475 1.8486040957306764 0.0905147438349328 0.22311457684564104 1.837028855690506e-07 6.735884021827706 0.5463261713057767 IVSLFAEHNDLQYAAPGGLIGVGTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVSLFAEHNDLQYAAPGGLIGVGTK 25 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 53021000.0 25341000.0 10844000.0 16836000.0 False True 21072164.296646595 10785581.21963453 20356329.759131297 1.0 0.5118402204822851 0.9660293775504961 24.328835163449032 -10.545775381109193 9.268739408782972 1.0000160938281752 0.7389347990163906 0.3058050406510523 0.18542194692032013 6.166938803814996e-05 3.0223612783488463e-06 0.17954507231799935 0.05984467603697964 2.8459326549346203e-11 10.545775381109193 -0.26108129481178466 IVSLFAEHNDLQYAAPGGLIGVGTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVSLFAEHNDLQYAAPGGLIGVGTK 25 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 88126000.0 29523000.0 34546000.0 24057000.0 False True 38218105.48533322 32623484.731625427 19678872.845664915 1.0 0.8536133415651695 0.5149096899430816 25.187752928276314 -6.957098446711091 0.47456159616763055 1.0085608071680199 0.34596985581111994 0.9996469882995933 0.0038170679708178627 0.08075435436926523 0.02508808225429167 0.004724216103876326 0.027947017801916062 1.1038283735945214e-07 6.957098446711091 -0.6625909513568999 IVSQK(ub)QMSDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVSQKQMSDR 10 1 H3BSC1;P62491;B4DQU5;H3BN38 H3BSC1 RAB11A Ras-related protein Rab-11A 1 10540200.0 4194100.0 4772000.0 1574100.0 True False 5498505.715722173 4060036.201110309 1411227.2318334025 1.0 0.7383890116729767 0.25665649992837225 22.390608171702848 -7.051553260584194 0.4347446097652336 1.019068726695323 4.292740686752225e-17 0.9997812786082132 0.004553185705613633 0.07356174092715657 0.021112452994586677 0.006512418854589796 0.03714153228952297 8.88069059491353e-08 7.051553260584194 -1.019068726695323 down IVSQK(ub)QMSDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVSQKQMSDR 10 1 H3BSC1;P62491;B4DQU5;H3BN38 H3BSC1 RAB11A Ras-related protein Rab-11A 1 11118100.0 5835500.0 3694000.0 1588600.0 True False 5650255.246691211 5169033.463955511 1172498.0030215504 1.0 0.9148318506464813 0.20751239578214897 22.429884611156055 -6.929406888648151 0.7516497017289893 1.010996504914248 0.06447498600701757 0.9964202640752546 0.021252753282725682 0.09294718811645879 0.07919903366163705 0.01929432766442918 0.06421035036166439 1.1765031961801929e-07 6.929406888648151 -0.9465215189072305 down IVSQK(ub)QMSDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVSQKQMSDR 10 1 H3BSC1;P62491;B4DQU5;H3BN38 H3BSC1 RAB11A Ras-related protein Rab-11A 1 8187800.0 3169200.0 2606100.0 2412500.0 True False 4807908.099554924 2141021.0934477625 1935668.3175636865 1.0 0.44531239972036074 0.40260093942787184 22.19697788933677 -13.999999999999998 0.36360899766568777 8.422959942712426 0.3977209072839303 0.9997797592544252 0.004038227649679871 22.091592075678086 0.19517324952947476 127.45934140072785 0.012181478229751014 1.0000000000000041e-14 13.999999999999998 -8.025239035428495 IVSQK(ub)QMSDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVSQKQMSDR 10 1 H3BSC1;P62491;B4DQU5;H3BN38 H3BSC1 RAB11A Ras-related protein Rab-11A 1 9701400.0 4194100.0 3732000.0 1775300.0 True False 5744772.111290774 3567107.899926349 1356010.7034511894 1.0 0.6209311406653635 0.23604255785640063 22.45381823322574 -7.544727741038971 0.336943424921541 1.067359992905522 1.8663679087764407e-13 0.9994323887515529 0.00743058671682239 0.1235061926097103 0.03970642924946035 0.023006323947043446 0.06829202125734947 2.8528061295630538e-08 7.544727741038971 -1.0673599929053352 down IVSQK(ub)QMSDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVSQKQMSDR 10 1 H3BSC1;P62491;B4DQU5;H3BN38 H3BSC1 RAB11A Ras-related protein Rab-11A 1 11320010.0 5835500.0 4628100.0 856410.0 True False 4852476.806482827 4603167.506694071 1035481.3714075572 1.0 0.948622258337086 0.2133923381198178 22.21028988659033 -6.921012983875776 0.8172009335534799 1.015639045507376 0.09203199945739876 0.9944570055434303 0.026751336550938535 0.09758024540171327 0.10256076718142654 0.023173189189755902 0.07009897146337155 1.19946344287993e-07 6.921012983875776 -0.9236070460499772 down IVSQK(ub)QMSDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVSQKQMSDR 10 1 H3BSC1;P62491;B4DQU5;H3BN38 H3BSC1 RAB11A Ras-related protein Rab-11A 1 6332400.0 3169200.0 1658500.0 1504700.0 True False 4102591.8742715186 1566203.0170613294 1230860.0395257953 1.0 0.381759401144291 0.3000201036922188 21.96810421142922 -13.999999999999998 0.28518447237407896 6.185485584088422 0.2766450380085395 0.9996167004864561 0.0061180235468885754 15.685755369367442 0.16925449348161387 47.5852897083965 0.03155778154536958 1.0000000000000041e-14 13.999999999999998 -5.908840546079882 IVSQLLTLMDGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVSQLLTLMDGLK 13 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 9196860.0 2633400.0 4620600.0 1942860.0 False True 3452412.9018818736 3931224.490957732 1741831.4844290966 1.0 1.1386889699128582 0.5045258298854238 21.719173587686395 -6.849400368490404 1.2379756613113313 1.0739728384063163 0.4794652356656627 0.9394308635605929 0.0669934347214838 0.15811602541662034 0.46661828571885167 0.04235176855883528 0.09796805089445773 1.414489185856301e-07 6.849400368490404 -0.5945076027406536 IVSQLLTLMDGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVSQLLTLMDGLK 13 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 439697000.0 260470000.0 85441000.0 93786000.0 False True 252201522.42406955 119558036.86892897 69220633.08030902 1.0 0.47405755413282397 0.2744655639465829 27.91000174367473 -13.999999999979476 0.13433982646653975 3.502686193374553 0.00976742829257737 0.9996264332755901 0.005914778091128951 11.932414662072963 0.11438698997274782 7.8572704077791204 0.23585120153212463 1.0000000000472583e-14 13.999999999979476 -3.4929187650819755 IVSQLLTLMDGLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 IVSQLLTLMDGLK 13 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 185072400.0 70284800.0 54146400.0 60641200.0 False True 106627180.10715574 44483551.87224591 48655440.240017824 1.0 0.4171877360682506 0.45631367340973655 26.667999998392787 -9.967285031860836 5.964491969288998 1.0000003900140597 0.43675070701393337 0.996394042212777 0.015973097032882366 8.284483155389836e-08 1.4334942025374783e-08 0.015465895529890809 0.005155294899580314 1.0782388309073163e-10 9.967285031860836 -0.5632496830001263 IVSQLLTLMDGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVSQLLTLMDGLK 13 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 25932300.0 2633400.0 7260900.0 16038000.0 False True 3607039.144959138 6940089.429414592 12250154.712978203 1.0 1.9240405081584475 3.396180141293415 21.782383649209287 -6.964236916790465 0.3709213732693596 0.8879672915496987 4.483570092252836 0.999896533048207 0.010036888456237833 0.07822094010753948 0.015779256554353756 0.01937715090222761 0.1249662625746253 1.0858331171754562e-07 6.964236916790465 3.595602800703137 IVSQLLTLMDGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IVSQLLTLMDGLK 13 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 476840400.0 268562100.0 77730100.0 130548200.0 False True 223321285.46830937 77311352.52308318 157845225.03332275 1.0 0.3461889105687336 0.7068077935442564 27.734545524706515 -10.688693720014497 6.8930041437012015 1.0033844337475974 0.5264983520567192 0.6968514914514323 0.14722204248374507 0.007689705924610786 0.0003472871020251306 0.1431525023346475 0.04751570989451546 2.0478883716265933e-11 10.688693720014497 -0.4768860816908782 IVSQLLTLMDGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IVSQLLTLMDGLK 13 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 133253400.0 70284800.0 38399600.0 24569000.0 False True 90985059.12053479 36262628.50403877 20097694.0992286 1.0 0.3985558602099596 0.22089004825070963 26.439126320485236 -13.999999999999998 0.1709290188186227 4.040546901952289 0.065708456751766 0.9995119364094549 0.0073652020859639004 12.100689490663168 0.13093977992095213 12.200501040958017 0.1436325882417313 1.0000000000000041e-14 13.999999999999998 -3.9748384452005228 IVSQLLTLMDGLK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 2 IVSQLLTLMDGLKQR 15 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 21107080.0 6774900.0 9878400.0 4453780.0 True False 8881959.508224927 8404581.225701608 3992945.569274482 1.0 0.9462530444907732 0.4495568309647111 23.082446563572653 -6.927515881079968 0.7669083495012807 1.0082899155699703 0.3537517498083122 0.9960270996514641 0.015618219645546874 0.09394836010314142 0.08415072422045748 0.014024088336135932 0.04557174497645152 1.1816371021951103e-07 6.927515881079968 -0.654538165761658 down IVSQLLTLMDGLK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 2 IVSQLLTLMDGLKQR 15 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 99768640.0 38938340.0 45077300.0 15753000.0 True False 37702263.71046976 63076900.965014055 11626816.720129965 1.0 1.6730268890326039 0.3083851094304782 25.168147812263122 -6.77262368535017 1.564570565558159 1.3847445326444563 0.29996884876278396 0.7404128201375338 0.2838560058145364 0.2622221697017535 1.2671635124170115 0.14297893117309593 0.3395144187137619 1.6880150510158917e-07 6.77262368535017 -1.0847756838816722 IVSQLLTLMDGLK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 2 IVSQLLTLMDGLKQR 15 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 155356000.0 70753300.0 48751900.0 35850800.0 True False 107337928.85909362 40051742.544666685 28764873.666036177 1.0 0.3731369048236812 0.26798424351746963 26.67758471504338 -13.999999999999998 0.251199812633095 5.386038850681222 0.22618394753240223 0.9995449565380471 0.006893455239959939 14.045899344933925 0.1585951136061226 31.108288151858908 0.04820587148023376 1.0000000000000041e-14 13.999999999999998 -5.159854903148819 IVSQLLTLMDGLK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IVSQLLTLMDGLKQR 15 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 97516250.0 38938340.0 45727410.0 12850500.0 True False 32378954.970943797 45481067.36614972 15537480.136001235 1.0 1.4046490199255501 0.4798635456253683 24.948553087697398 -6.787796198372727 1.505313044862772 1.2268123221623748 0.4706429897500881 0.7940292708803103 0.17178847039308653 0.23866372668032637 1.0684367074522612 0.08984180946978604 0.2106675276125362 1.630060792774114e-07 6.787796198372727 -0.7561693324122867 down IVSQLLTLMDGLK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVSQLLTLMDGLKQR 15 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 98937100.0 52469100.0 33333000.0 13135000.0 True False 67922284.27058557 31477989.247938074 10744564.77648123 1.0 0.4634412635849754 0.15818909643376455 26.017381642690683 -8.62827994412505 0.29234674202926403 1.2016079719378616 1.297386026464941e-18 0.9988121459200724 0.011992718920188255 0.23078716636976085 0.08559685468138238 0.1442682090645885 0.09925701816270772 2.3535317196641916e-09 8.62827994412505 -1.2016079719378616 IVSWLEYESSFSNEEAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVSWLEYESSFSNEEAQK 18 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 9068800.0 2243600.0 1548900.0 5276300.0 False True 2172378.146084548 2167383.8474067934 3894278.7443929208 1.0 0.9977009993924142 1.7926339166189333 21.050843824398413 -6.906247796230556 0.9209130141345805 0.9723719545362285 1.8875273668872454 0.9894266503083141 0.03847719674886755 0.10695203083272548 0.15261575965464275 0.030928590644924373 0.08331188268974057 1.2409440577409098e-07 6.906247796230556 0.9151554123510169 IVTGGSDNHLILVDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVTGGSDNHLILVDLR 16 0 P34896-2;P34896;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 0 31034900.0 13410000.0 10731000.0 6893900.0 False True 17580639.862624746 9129976.62911039 6180585.358958321 1.0 0.5193199280829423 0.3515563373832501 24.067484243784797 -13.999999999999998 0.14677194709405927 3.313514549981489 0.15995294898288379 0.9995773691237289 0.005649505822300273 11.947055904812643 0.12047972243420843 7.891142861613076 0.1721888129977567 1.0000000000000041e-14 13.999999999999998 -3.153561600998605 IVTGGSDNHLILVDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVTGGSDNHLILVDLR 16 0 P34896-2;P34896;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 0 36338200.0 16231000.0 9662200.0 10445000.0 False True 15715755.789400216 13520366.847707344 7709141.15671666 1.0 0.8603064993429338 0.49053582023183595 23.905708318938117 -6.9542265358982664 0.5103480976555229 1.0067858967715344 0.32782465968611074 0.9994925364502135 0.004841971842612965 0.08183183577621314 0.02927346680953437 0.005573657771081415 0.03051872271230186 1.11115197901548e-07 6.9542265358982664 -0.6789612370854237 down IVTGGSDNHLILVDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVTGGSDNHLILVDLR 16 0 P34896-2;P34896;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 0 89779000.0 25224000.0 35346000.0 29209000.0 False True 38266652.121410206 29038230.140441515 23435828.347240515 1.0 0.7588390551729143 0.6124347714789546 25.189584352019217 -11.047428459251051 0.07062488968549065 2.0075325379464135 9.017157452798634e-16 0.999967408982722 0.0009122075457866903 3.4863285052111888 0.04413196257881468 0.9584281388511842 0.3903014969359378 8.965438602571082e-12 11.047428459251051 -2.0075325379464126 IVTGGSDNHLILVDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVTGGSDNHLILVDLR 16 0 P34896-2;P34896;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 0 71411000.0 13410000.0 17145000.0 40856000.0 False True 18368039.391623802 16387477.209066808 31206654.25573246 1.0 0.8921734573663768 1.6989649025885325 24.13069430530769 -6.873213154488723 1.1170072553135642 0.9376607118106371 1.7491816916167713 0.9677837662831177 0.06419052741008564 0.13380886614330934 0.3100950890517493 0.044507188253757074 0.10599748735792668 1.3390193269347069e-07 6.873213154488723 0.8115209798061341 IVTGGSDNHLILVDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVTGGSDNHLILVDLR 16 0 P34896-2;P34896;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 0 27767500.0 16231000.0 5866400.0 5670100.0 False True 13496795.655217666 5834796.538810773 6855691.694419717 1.0 0.43230976358118933 0.507949580741367 23.686113594372394 -10.59839341431163 6.479504223592039 1.0013242135637102 0.4701296721616044 0.9849465623621831 0.030879826046641693 0.0005919574632101275 3.6690083741611006e-05 0.029962255079151227 0.009966421001035442 2.5211958622035477e-11 10.59839341431163 -0.5311945414021058 IVTGGSDNHLILVDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVTGGSDNHLILVDLR 16 0 P34896-2;P34896;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 0 72665000.0 25224000.0 31576000.0 15865000.0 False True 32652965.239374172 29818767.842465192 12977732.788646713 1.0 0.9132024495744295 0.3974442349571878 24.960710674111667 -6.936040534417722 0.6954231316473597 1.0063718286765524 0.2731936318602561 0.9975979287687611 0.013034958964138862 0.08962031008474929 0.06318882373675451 0.01233590711799353 0.04521848287221157 1.1586692079389696e-07 6.936040534417722 -0.7331781968162963 down IVTGNFILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVTGNFILR 9 0 H3BTR7;Q8NEZ5 H3BTR7 FBXO22 F-box only protein 22 0 8541100.0 2922400.0 3720000.0 1898700.0 False True 3831294.700561857 3164990.5004464295 1702240.7376164647 1.0 0.8260890241573653 0.44429908703364224 21.869400570467615 -6.958182615189688 0.4603362931770993 1.011091205228416 0.2438976527535321 0.9996967286272906 0.004041855014298568 0.08035688943069422 0.02357963933846015 0.005188106997570887 0.03153851132534223 1.1010762239344242e-07 6.958182615189688 -0.7671935524748839 down IVTGNFILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVTGNFILR 9 0 H3BTR7;Q8NEZ5 H3BTR7 FBXO22 F-box only protein 22 0 7320330.0 2922400.0 2058430.0 2339500.0 False True 4002890.25489048 1967481.756282261 1786958.283514935 1.0 0.4915152879543763 0.4464170061449328 21.932610631990507 -13.999999999999998 0.3429399209206724 6.987755870405201 0.4395913026607894 0.9997410300620146 0.004039351266551834 19.976979728544393 0.18803703986546252 86.8414604378954 0.013789284525542551 1.0000000000000041e-14 13.999999999999998 -6.548164567744411 IVVFQYSDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVVFQYSDGK 10 0 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 0 47368000.0 13354000.0 14304000.0 19710000.0 False True 17507223.32031994 12169898.956555301 17670598.271670397 1.0 0.6951358724275929 1.0093318596765049 24.061446951885937 -10.979533057970677 10.45598473362364 1.0902761184053422 0.8522338660520493 0.22774466264080906 0.128269974664974 0.07657504483929013 0.00014989086044389627 0.03523169530426602 0.041398956307990994 1.0482549986414756e-11 10.979533057970677 -0.2380422523532929 IVVFQYSDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVVFQYSDGK 10 0 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 0 27449800.0 9877700.0 5325100.0 12247000.0 False True 9564137.820279624 7451440.200029638 9039143.297875438 1.0 0.7791021355034993 0.9451080136788705 23.18920348891798 -10.264433178330556 5.774882643147762 1.000007793560466 0.862105074682602 0.47916697797438035 0.06777161597205235 6.800696297842287e-06 8.661740302535323e-07 0.06562329330329066 0.021873195000442935 5.4395982034331674e-11 10.264433178330556 -0.1379027188778641 IVVFQYSDGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVVFQYSDGK 10 0 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 0 36245600.0 9347300.0 17461000.0 9437300.0 False True 14180537.479164984 14344948.126584318 7572013.518484475 1.0 1.01159410548866 0.5339722510243209 23.757408879710724 -6.901336538458091 0.9527693135451731 1.019136113699854 0.48245257234454614 0.9872198921140768 0.025150120792871294 0.11042850551693408 0.17191882183652268 0.019746716394742174 0.051731420317588615 1.255057032494093e-07 6.901336538458091 -0.5366835413553079 IVVFQYSDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVVFQYSDGK 10 0 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 0 33447700.0 13354000.0 10141000.0 9952700.0 False True 18291334.67828067 9692937.088197513 7602077.242290686 1.0 0.5299196181515946 0.41561085486656557 24.12465701340883 -13.999999999999881 0.19860670504460923 3.59938901556967 0.3403460293575359 0.9994869244640515 0.005728115129621629 12.503709237217755 0.14131485032725996 12.61848452384979 0.0735493913441664 1.000000000000274e-14 13.999999999999881 -3.259042986212134 IVVFQYSDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVVFQYSDGK 10 0 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 0 20478900.0 9877700.0 6758200.0 3843000.0 False True 8213745.20630544 6721792.235202323 4646553.531975622 1.0 0.8183589904934243 0.5657046104143341 22.969608764352255 -6.966481198802773 0.33165039712023875 1.0301949846607 0.3455771987143028 0.9999405002806032 0.0013736937425559979 0.07746186388056918 0.013106952126062953 0.003665262642384903 0.022008003233984986 1.0802363847680464e-07 6.966481198802773 -0.6846177859463971 IVVFQYSDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVVFQYSDGK 10 0 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 0 37214000.0 9347300.0 18345000.0 9521700.0 False True 12100264.112829138 17324084.62344896 7788848.300892375 1.0 1.4317112801762186 0.643692420947602 23.528535201803173 -6.757974268560859 1.6202977723860261 1.2513942041572104 0.6411180463670801 0.6825717970606165 0.18152877416546548 0.2863305742555579 1.4811323481753802 0.0884196969066989 0.2128965325026981 1.745925593901637e-07 6.757974268560859 -0.6102761577901302 IVVFQYSDGK(ub)LQTVAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVVFQYSDGKLQTVAEK 17 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 16668400.0 3947300.0 4824300.0 7896800.0 True False 5174948.525707577 4104533.244974113 7079714.887454426 1.0 0.7931544100552952 1.3680744556751716 22.303113081776573 -6.809425192424227 1.4172360374886492 0.8871950612608109 1.377972851342088 0.8582439119673231 0.08952036804741584 0.20759131489971477 0.8219446791964862 0.04967199437276466 0.11491638007749168 1.5508679020386733e-07 6.809425192424227 0.490777790081277 IVVFQYSDGK(ub)LQTVAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVVFQYSDGKLQTVAEK 17 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 36516000.0 7798300.0 8860700.0 19857000.0 True False 7550747.235073615 12398823.71794007 14655856.002769034 1.0 1.642065789243598 1.9409808786462641 22.84818799243624 -10.327499836098138 0.16701954428503038 1.7273109591635557e-15 2.2982404771009413 0.9995999648314574 0.007851864388462105 2.0241130165842023 0.08386078982265921 1.0876530913066924 0.2333947284271819 4.7043558326738363e-11 10.327499836098138 2.2982404771009395 IVVFQYSDGK(ub)LQTVAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVVFQYSDGKLQTVAEK 17 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 120126000.0 13961000.0 30243000.0 75922000.0 True False 21179857.6858154 24845900.36036248 60915983.42220524 1.0 1.1730909965935374 2.8761280800768536 24.336189559648577 -6.926461084028544 0.7752791619172688 0.9704231048376667 3.196211844473099 0.995796013317216 0.054890147245925225 0.09451752573620664 0.08698767050212891 0.04899234039504259 0.15720057313489497 1.184510503072163e-07 6.926461084028544 2.225788739635432 up IVVFQYSDGK(ub)LQTVAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVVFQYSDGKLQTVAEK 17 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 27108300.0 3947300.0 5508000.0 17653000.0 True False 5406723.481771558 5264638.347479733 13483724.974947268 1.0 0.9737206582191865 2.493881002127598 22.366323143299464 -6.902967163031323 0.9423142151758288 0.9418391807465761 2.663424846177991 0.9879856958325746 0.07787746037943129 0.10925420639221314 0.16535598634946408 0.06162063475017155 0.162850939052955 1.2503535657700589e-07 6.902967163031323 1.7215856654314146 up IVVFQYSDGK(ub)LQTVAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVVFQYSDGKLQTVAEK 17 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 41627300.0 7798300.0 11381000.0 22448000.0 True False 6484631.973266221 11319688.294048386 27141773.01217503 1.0 1.7456176912915558 4.185553339660707 22.628593267870517 -6.949482319550983 0.5644976977696974 0.9688086197080967 5.079874845605373 0.9991600344846229 0.03942826114710345 0.08369427443110683 0.03682771900127885 0.04203888198020067 0.20302893037699218 1.1233567014241706e-07 6.949482319550983 4.111066225897276 IVVFQYSDGK(ub)LQTVAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVVFQYSDGKLQTVAEK 17 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 99075000.0 13961000.0 34575000.0 50539000.0 True False 18072789.712452535 32650870.85613237 41341420.573931076 1.0 1.8066314816707698 2.287495247368809 24.107315881741027 -8.962021425321302 0.15481359534239245 1.2371850908741241e-19 3.0729231616247987 0.9998253520848785 0.007019995462160358 0.4478365088711144 0.04992386494724931 0.557310864171419 0.34808995696174494 1.0913864930681613e-09 8.962021425321302 3.0729231616247987 IVVFVDMGHSAFQVSACAFNK ddPTM_RPMI8226_Bortezomib_8h_R1 2 IVVFVDMGHSAFQVSACAFNK 21 0 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 270127000.0 61565000.0 77289000.0 131273000.0 False True 93398606.00438546 63496174.08828679 105326834.01100005 1.0 0.6798407043174218 1.1277131267468223 26.47689768175281 -6.714797708524005 1.778057823801838 0.8041442534130244 1.1268185255945429 0.48785299154225337 0.13481713732573306 0.3655238067261463 2.255456740158133 0.06027285520650997 0.15223976614735535 1.928422950586211e-07 6.714797708524005 0.32267427218151845 IVVFVDMGHSAFQVSACAFNK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IVVFVDMGHSAFQVSACAFNK 21 0 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 172715200.0 61565000.0 35147000.0 76003200.0 False True 79697106.1275797 33191038.553303972 62171397.45868731 1.0 0.41646478982777013 0.7800960471408195 26.24802400384526 -10.087839412426483 5.216818535158663 1.000007004009739 0.5982804184837224 0.6193782364191084 0.14845183915938115 1.2093382526963777e-05 2.1142960637194258e-06 0.14374037908033804 0.04791262506454254 8.168843720386431e-11 10.087839412426483 -0.4017265855260167 IVVLFYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVVLFYK 7 0 E7ETZ4;Q9Y6E2;B5MCH7;E9PFD4;B5MCE7;Q7L1Q6-2;Q7L1Q6;Q7L1Q6-4;Q7L1Q6-3 E7ETZ4;Q7L1Q6-2 BZW2;BZW1 Basic leucine zipper and W2 domain-containing protein 2;Basic leucine zipper and W2 domain-containing protein 1 0 26100300.0 7805200.0 8963400.0 9331700.0 False True 10232692.785664307 7626095.659059548 8366145.199987131 1.0 0.7452677236380513 0.8175897952988335 23.286682511867376 -9.95658770108528 6.390469660452006 1.0000000469567878 0.7814287594684346 0.9241170921992347 0.02952536211834734 1.9745236869946312e-08 3.266363140544604e-09 0.028587814907632 0.009529269647921088 1.1051272783167824e-10 9.95658770108528 -0.2185712874883532 IVVLFYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVVLFYK 7 0 E7ETZ4;Q9Y6E2;B5MCH7;E9PFD4;B5MCE7;Q7L1Q6-2;Q7L1Q6;Q7L1Q6-4;Q7L1Q6-3 E7ETZ4;Q7L1Q6-2 BZW2;BZW1 Basic leucine zipper and W2 domain-containing protein 2;Basic leucine zipper and W2 domain-containing protein 1 0 15260200.0 5842000.0 3082400.0 6335800.0 False True 5656548.90774912 4313218.394503647 4676263.910074239 1.0 0.7625176525203922 0.8266991033469273 22.43149069443317 -10.071958408504072 10.19596044196592 1.0000000000708589 0.7946083779336598 0.9317629369065821 0.026201967579423464 3.7534076217640634e-11 0.0 0.025369946018243442 0.008456648672747813 8.473085552657484e-11 10.071958408504072 -0.20539162213719908 IVVLFYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVVLFYK 7 0 E7ETZ4;Q9Y6E2;B5MCH7;E9PFD4;B5MCE7;Q7L1Q6-2;Q7L1Q6;Q7L1Q6-4;Q7L1Q6-3 E7ETZ4;Q7L1Q6-2 BZW2;BZW1 Basic leucine zipper and W2 domain-containing protein 2;Basic leucine zipper and W2 domain-containing protein 1 0 27273100.0 5957100.0 10723000.0 10593000.0 False True 9037356.222345885 8809396.870818606 8499288.906923166 1.0 0.9747758806979829 0.9404618671451406 23.107469359359317 -6.96683219087971 0.32511491790272184 1.0044259749017546 0.9096966669530068 0.9999459957254448 0.0001792210796615884 0.0773449782750551 0.012698849715070388 0.0005097863002299598 0.0030050159437914345 1.0793637021641996e-07 6.96683219087971 -0.09472930794874779 IVVLFYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVVLFYK 7 0 E7ETZ4;Q9Y6E2;B5MCH7;E9PFD4;B5MCE7;Q7L1Q6-2;Q7L1Q6;Q7L1Q6-4;Q7L1Q6-3 E7ETZ4;Q7L1Q6-2 BZW2;BZW1 Basic leucine zipper and W2 domain-containing protein 2;Basic leucine zipper and W2 domain-containing protein 1 0 28291900.0 7805200.0 8161700.0 12325000.0 False True 10690993.367598942 7801089.10686734 9414088.841342837 1.0 0.7296879568282216 0.8805625929835479 23.349892573390267 -10.128152400666211 4.94329048335567 1.0000095490306884 0.8051252751321112 0.6898669515591798 0.06159431228717158 6.482484452126215e-06 1.1433036966893503e-06 0.05964135780927224 0.01987947880876643 7.444706817597895e-11 10.128152400666211 -0.1948842738985772 IVVLFYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVVLFYK 7 0 E7ETZ4;Q9Y6E2;B5MCH7;E9PFD4;B5MCE7;Q7L1Q6-2;Q7L1Q6;Q7L1Q6-4;Q7L1Q6-3 E7ETZ4;Q7L1Q6-2 BZW2;BZW1 Basic leucine zipper and W2 domain-containing protein 2;Basic leucine zipper and W2 domain-containing protein 1 0 14793000.0 5842000.0 3698700.0 5252300.0 False True 4857881.844481641 3678774.3689655303 6350531.646108648 1.0 0.7572795071466116 1.3072635048385535 22.211895969867445 -6.78678405123918 1.509583418576881 0.8637726039544893 1.3125713100989358 0.7905963581393257 0.10298195104592404 0.24018445369314473 1.0813919803933103 0.05371132778642896 0.12602939510202987 1.633864169211958e-07 6.78678405123918 0.4487987061444465 IVVLFYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVVLFYK 7 0 E7ETZ4;Q9Y6E2;B5MCH7;E9PFD4;B5MCE7;Q7L1Q6-2;Q7L1Q6;Q7L1Q6-4;Q7L1Q6-3 E7ETZ4;Q7L1Q6-2 BZW2;BZW1 Basic leucine zipper and W2 domain-containing protein 2;Basic leucine zipper and W2 domain-containing protein 1 0 32937100.0 5957100.0 13083000.0 13897000.0 False True 7711583.381996343 12354919.549118727 11367888.595261484 1.0 1.6021248733383127 1.4741315800074526 22.878595681451767 -10.059535883716789 4.41848545446528 0.9999639244743962 1.5381282266541962 0.9592978253309751 0.05225304337531081 7662566.98600258 5815105.601408614 2459.3092274882792 0.01788760679933909 8.718948577267117e-11 10.059535883716789 0.5381643021798 IVVLLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVVLLQR 7 0 Q06323;Q06323-3;Q06323-2;H0YLU2 Q06323 PSME1 Proteasome activator complex subunit 1 0 99809000.0 27248000.0 27143000.0 45418000.0 False True 35722391.87000736 23093370.20258531 40718581.0402195 1.0 0.6464676353873879 1.139861552059367 25.090325346671502 -6.714376017745038 1.7796236796117204 0.7836336296336597 1.1388573995621574 0.4858423515075042 0.1488791127575176 0.3663506810174067 2.264308381291833 0.06650813275553583 0.16807029510836022 1.930296317937304e-07 6.714376017745038 0.3552237699284977 IVVLLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVVLLQR 7 0 Q06323;Q06323-3;Q06323-2;H0YLU2 Q06323 PSME1 Proteasome activator complex subunit 1 0 56188000.0 25022000.0 10913000.0 20253000.0 False True 24227690.30635031 15270617.81054317 14948131.723023677 1.0 0.6302960627881476 0.6169854218049678 24.530153539392767 IVVLLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVVLLQR 7 0 Q06323;Q06323-3;Q06323-2;H0YLU2 Q06323 PSME1 Proteasome activator complex subunit 1 0 98142000.0 23533000.0 43945000.0 30664000.0 False True 35701281.49275079 36102671.406147815 24603246.95949135 1.0 1.011243011360209 0.6891418439555757 25.089472524741957 -6.898812842370384 0.9687582306963682 1.013831495251569 0.6561371903452037 0.9859659057521252 0.017682235069055453 0.1122838651724477 0.18239611653773086 0.013719672295176314 0.03548770759164672 1.262371431770578e-07 6.898812842370384 -0.35769430490636533 IVVLLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVVLLQR 7 0 Q06323;Q06323-3;Q06323-2;H0YLU2 Q06323 PSME1 Proteasome activator complex subunit 1 0 96570000.0 27248000.0 33463000.0 35859000.0 False True 37322321.949512675 31984494.012656886 27389842.73928706 1.0 0.856980282628812 0.7338729561450743 25.153535408194394 -6.972872852651801 0.17654929867272048 1.0996336437323004 0.4879018545894489 0.9999969882317773 0.00018863648358720194 0.07538105020953706 0.005546386536786945 0.0048886566446017035 0.013963474657902621 1.0644546104194837e-07 6.972872852651801 -0.6117317891428515 IVVLLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVVLLQR 7 0 Q06323;Q06323-3;Q06323-2;H0YLU2 Q06323 PSME1 Proteasome activator complex subunit 1 0 52713000.0 25022000.0 15507000.0 12184000.0 False True 20806901.66255044 15423460.713101512 14731618.067549048 1.0 0.7412665741032275 0.708015941367375 24.310558814827044 -13.999999999999998 0.2892583058473279 3.220208513870405 0.6988871313072974 0.9996258010298618 0.0025246700529731386 15.92180623598858 0.1705399131373398 21.02621622991916 0.012600151505165027 1.0000000000000041e-14 13.999999999999998 -2.5213213825631073 IVVLLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVVLLQR 7 0 Q06323;Q06323-3;Q06323-2;H0YLU2 Q06323 PSME1 Proteasome activator complex subunit 1 0 96959000.0 23533000.0 46588000.0 26838000.0 False True 30463932.40478085 43995336.845856644 21953759.381134626 1.0 1.4441778645409629 0.7206475871017005 24.860598846834407 -6.740602917589659 1.6846101714973247 1.2640988241424311 0.7201767800641791 0.6076142004087527 0.18662162793494153 0.31671676539306565 1.765080181641938 0.08763241510409016 0.21488983304888015 1.8171763769553072e-07 6.740602917589659 -0.5439220440782521 IVVNLTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVVNLTGR 8 0 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 286328000.0 68780000.0 67058000.0 150490000.0 False True 90171246.06646743 57053207.790036686 134918738.40201285 1.0 0.6327206318961298 1.4962501272585382 26.426164122407112 -6.791141804648939 1.4916697741643585 0.795025343793951 1.5057350431813912 0.8049983743979892 0.15625332937689504 0.23367380327989173 1.02712057055425 0.08244316189839317 0.192868509623682 1.6175517928105199e-07 6.791141804648939 0.7107096993874402 IVVNLTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVVNLTGR 8 0 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 146908000.0 54496000.0 37938000.0 54474000.0 False True 52766054.30960225 53086841.24405644 40205625.21502953 1.0 1.006079418646162 0.7619600468726538 25.653106771282534 -6.901188271122495 0.9537102584964472 1.0098213232876938 0.7357067736752787 0.9871486913845201 0.012886396587729127 0.11053639437552923 0.17252152403576407 0.010110724312425035 0.026467173521688012 1.2554855798000334e-07 6.901188271122495 -0.2741145496124151 IVVNLTGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVVNLTGR 8 0 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 208867000.0 58503000.0 101700000.0 48664000.0 False True 88753328.14220032 83550840.41427325 39045539.06981108 1.0 0.9413826181301994 0.4399332384161689 26.403297884045475 -6.928870590135163 0.7560057696764493 1.0079536425208915 0.3398879852525816 0.9963115726096158 0.015264702554542443 0.09322853227718729 0.08058448814168163 0.013814576810944916 0.04565756050483616 1.17795692556698e-07 6.928870590135163 -0.6680656572683099 down IVVNLTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVVNLTGR 8 0 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 253191000.0 68780000.0 74561000.0 109850000.0 False True 94209824.70961098 71266648.47974506 83905692.43176553 1.0 0.756467265483349 0.8906257143604019 26.489374183930003 -10.097809980766305 4.7779973519436725 1.0000086291605903 0.8235464900117551 0.6975701716398182 0.0547699574121677 5.0347391202334e-06 9.507393504516977e-07 0.05303337555860543 0.017676927743181744 7.983439146305734e-11 10.097809980766305 -0.17646213914883524 IVVNLTGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVVNLTGR 8 0 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 115771000.0 54496000.0 35028000.0 26247000.0 False True 45315838.5821417 34839297.211486384 31735126.347583666 1.0 0.7688106035671165 0.7003098108856362 25.43351204671681 -13.999999999999998 0.1704939098419957 2.1674097433770094 0.6402009001689951 0.9995127427100521 0.002830231707784028 12.096344838153989 0.13076464667918108 4.670535424753834 0.055597609149745486 1.0000000000000041e-14 13.999999999999998 -1.5272088432080144 IVVNLTGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVVNLTGR 8 0 P62244;I3L3P7;I3L246;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 0 186832000.0 58503000.0 75425000.0 52904000.0 False True 75733286.76653612 71227532.44609633 43276014.84088028 1.0 0.9405049679894426 0.5714266036582798 26.174424206137925 -6.9351333150753725 0.7033827453249618 1.0046892090487702 0.4846980456112679 0.9974543899830126 0.00956460866348466 0.09005874513450861 0.06525608223288377 0.008997210560026536 0.03250454878797868 1.161092139482441e-07 6.9351333150753725 -0.5199911634375023 IVVVTAGVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVVVTAGVR 9 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 357750000.0 131520000.0 121210000.0 105020000.0 False True 172423993.64149192 103125940.47287956 94153537.82297438 1.0 0.5980950695719384 0.5460582128653201 27.361385305562006 -13.999999999999998 0.28818687828652445 4.428071328219988 0.5316171588186438 0.9996234057301532 0.003936326736042083 15.85873405586737 0.17020031339185193 32.19657874599312 0.019815220470909403 1.0000000000000041e-14 13.999999999999998 -3.8964541694013444 IVVVTAGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVVVTAGVR 9 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 235710000.0 122780000.0 42973000.0 69957000.0 False True 118882416.10637425 60132343.00123453 51633163.03498587 1.0 0.5058136011252412 0.4343212791771095 26.824960100993692 -13.999999999999998 0.27229481562699026 4.861746694453926 0.4111131983124056 0.9995882828044276 0.005103376699800752 14.996791271820474 0.16520784257357446 32.10321921686732 0.029355648869373106 1.0000000000000041e-14 13.999999999999998 -4.45063349614152 IVVVTAGVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVVVTAGVR 9 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 898520000.0 216760000.0 328800000.0 352960000.0 False True 328840767.27865887 270123071.07387465 283197301.2921365 1.0 0.8214403381590855 0.8611988824735827 28.292813924009277 -10.617507892309721 6.501245155195297 1.0005174260579461 0.8413196103163342 0.9550329786443625 0.016231357747725227 0.00012212075251223696 7.184800813129346e-06 0.015766251367567388 0.005238648186939547 2.4126376880168375e-11 10.617507892309721 -0.15919781574161196 IVVVTAGVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVVVTAGVR 9 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 457940000.0 131520000.0 133420000.0 193000000.0 False True 180146498.19435963 127525063.23906037 147417374.95977002 1.0 0.7078964316113094 0.8183194035818657 27.424595367084898 -10.353994773807118 6.812069458120224 1.0000094171079457 0.7631079177533351 0.8598753496809652 0.045079989534918666 6.447643878720843e-06 6.11452069106265e-07 0.043650246252540464 0.014549504059662056 4.425936983941905e-11 10.353994773807118 -0.23690149935461058 IVVVTAGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVVVTAGVR 9 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 247680000.0 122780000.0 64379000.0 60521000.0 False True 102097010.07625079 64032177.548769094 73175661.28251263 1.0 0.6271699582676015 0.7167267800287359 26.60536537642797 -9.764952368169952 5.904132385777927 1.000000016751646 0.6719483691467392 0.9470637201408393 0.036561419388445766 8.103077222230872e-09 1.608219298006873e-09 0.03540044420908715 0.011800147366352735 1.7180968113977247e-10 9.764952368169952 -0.3280516476049069 IVVVTAGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVVVTAGVR 9 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 938590000.0 216760000.0 465530000.0 256300000.0 False True 280600092.978384 439622846.2662408 209656029.86007902 1.0 1.5667238082494401 0.747170208087671 28.063940246101726 -6.720707525061562 1.7570787436386226 1.3445326885081934 0.7484231517257481 0.515727148325839 0.23845882742031488 0.35393819837476026 2.13597980948213 0.10774962065808957 0.27023541290507086 1.9023589893099965e-07 6.720707525061562 -0.5961095367824453 IVVVWVGTNNHGHTAEQVTGGIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVVVWVGTNNHGHTAEQVTGGIK 23 0 M0R389;Q15102;M0QZT2 M0R389 PAFAH1B3 Platelet-activating factor acetylhydrolase IB subunit gamma 0 114536000.0 32658000.0 35382000.0 46496000.0 False True 49544573.619608976 29067805.65917225 37306045.220079206 1.0 0.5867000871245295 0.7529794384044118 25.562223718782136 -10.124959709762964 5.200385055685808 1.000009293478947 0.6698397627641269 0.8401708520614728 0.06788326090065178 7.31459547869316e-06 1.2308439159231006e-06 0.06572953406099033 0.021909228246033786 7.49963781519586e-11 10.124959709762964 -0.33016953071482014 IVYLQYPSLIPHHQCSQLCLYDWYTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVYLQYPSLIPHHQCSQLCLYDWYTK 26 0 C9JIF9;P13798;H7C1U0 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 319299000.0 126830000.0 52449000.0 140020000.0 False True 192410382.5150039 43089066.16409264 112344985.62705398 1.0 0.22394356063780815 0.58388213857583 27.519611408512315 -10.644989872565992 6.591839411525112 1.0027235792106564 0.4039128496188031 0.7852603634585116 0.14694430911519135 0.005898449623162845 0.0003176663386349106 0.1426839187338099 0.047426071835257565 2.2646971180802967e-11 10.644989872565992 -0.5988107295918532 IVYLQYPSLIPHHQCSQLCLYDWYTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVYLQYPSLIPHHQCSQLCLYDWYTK 26 0 C9JIF9;P13798;H7C1U0 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 214360000.0 126830000.0 34521000.0 53009000.0 False True 164183935.1930633 32599876.003602203 43361905.91827132 1.0 0.19855703888001056 0.2641056560575321 27.290737730604764 -10.846206912236394 10.942405796291785 1.0159541178241946 0.23133134746877276 0.9945756483894206 0.026760110904993382 0.00915259047836755 0.00012863736760992535 0.02276889110562437 0.00863678865647524 1.4249285488277654e-11 10.846206912236394 -0.7846227703554218 IVYLYTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IVYLYTK 7 0 P49207 P49207 RPL34 60S ribosomal protein L34 0 111858000.0 46599000.0 27923000.0 37336000.0 False True 61091740.2653579 23756997.243001528 33472828.872201193 1.0 0.38887412831604906 0.5479108751331803 25.86447400196873 -10.493044421973627 9.404572293521833 1.0000090759211664 0.46839250172504177 0.9370987336832384 0.06492648000902802 1.235552817683322e-05 6.659931312647731e-07 0.0628658650500904 0.02095493131690286 3.213331844979894e-11 10.493044421973627 -0.5316165741961246 IVYLYTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IVYLYTK 7 0 P49207 P49207 RPL34 60S ribosomal protein L34 0 72727000.0 23629000.0 17311000.0 31787000.0 False True 22878910.328860674 24223372.575672437 23461031.1104406 1.0 1.0587642605126952 1.0254435536138977 24.447515005637925 -10.321628845896162 3.8620626434448297 0.9998989792694415 1.04210390706898 0.6803987513861399 0.0136031216471029 1.1860716227400249e-05 2.083319308111699e-06 0.013202760904958267 0.00439038863044731 4.768383253861381e-11 10.321628845896162 0.04220492779953844 IVYLYTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IVYLYTK 7 0 P49207 P49207 RPL34 60S ribosomal protein L34 0 101428000.0 32479000.0 46051000.0 22898000.0 False True 49273017.532955974 37832839.251894765 18372200.263450082 1.0 0.767820627721663 0.3728653365132741 25.554294490773866 -6.963082648002601 0.3895595419691147 1.024376068056583 0.10212874568153399 0.9998680041965249 0.0029743138547731218 0.07861775031073652 0.017192542192033346 0.005100603895325133 0.0332291621085013 1.0887228852338686e-07 6.963082648002601 -0.922247322375049 down IVYLYTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IVYLYTK 7 0 P49207 P49207 RPL34 60S ribosomal protein L34 0 136272000.0 46599000.0 28422000.0 61251000.0 False True 63827909.59062464 27166222.06101465 46784775.30394232 1.0 0.42561666573841483 0.7329830414940348 25.927684063491622 -10.085685819690514 5.315658953540404 1.0000058048406755 0.57929985361584 0.7141124441455111 0.12548179744971158 8.632363969594785e-06 1.48500476456501e-06 0.12149890380281685 0.040499075981039086 8.209452234179104e-11 10.085685819690514 -0.42070595122483545 IVYLYTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IVYLYTK 7 0 P49207 P49207 RPL34 60S ribosomal protein L34 0 51955000.0 23629000.0 17211000.0 11115000.0 False True 19648560.442187056 17118280.92688398 13439095.11004657 1.0 0.8712231604575794 0.6839735231285311 24.2279202810722 -6.9657690079536465 0.34459987164657196 1.0192576079726117 0.5296725985342942 0.9999281285259864 0.0010999781650094611 0.07770098103154789 0.01394523296095218 0.002607788569744066 0.016153962593853655 1.0820092961295391e-07 6.9657690079536465 -0.4895850094383175 IVYLYTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IVYLYTK 7 0 P49207 P49207 RPL34 60S ribosomal protein L34 0 87460000.0 32479000.0 32911000.0 22070000.0 False True 42044705.75680436 31079473.91890594 18053486.45732323 1.0 0.7392006522456434 0.429387865424686 25.325420812866316 -6.968843241764021 0.28445981677666426 1.064690231246299 0.0943996183759329 0.9999719014327174 0.0012363348872735133 0.07667984224289366 0.010367241588980013 0.0055795479848644094 0.028280334095739962 1.0743771379065352e-07 6.968843241764021 -0.970290612870366 down IWCFGPDGTGPNILTDITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IWCFGPDGTGPNILTDITK 19 0 P13639 P13639 EEF2 Elongation factor 2 0 10686900.0 3392400.0 5290900.0 2003600.0 False True 4447469.252048333 4501518.3437666735 1796286.6918883193 1.0 1.0121527746804426 0.40388962578235227 22.08455320065793 -6.902345231842851 0.9463562086760173 1.0236878686382762 0.3369198644931905 0.9876964653532073 0.03149243248198177 0.10969848574899106 0.16785797978079373 0.024844781284479034 0.06543418250146912 1.2521454166513837e-07 6.902345231842851 -0.6867680041450857 down IWCFGPDGTGPNILTDITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IWCFGPDGTGPNILTDITK 19 0 P13639 P13639 EEF2 Elongation factor 2 0 16788300.0 3392400.0 3388900.0 10007000.0 False True 4646661.956162904 3239167.1924063247 7643552.700634289 1.0 0.697095511350937 1.644955620345178 22.14776326218082 -6.820726520526659 1.3686917722897336 0.836854380532099 1.6659787793739933 0.886053584725584 0.13342772711891857 0.19253915707891892 0.7085260481135335 0.07660218648955504 0.17652553577524588 1.5110313658356302e-07 6.820726520526659 0.8291243988418943 IWCFGPDGTGPNILTDITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IWCFGPDGTGPNILTDITK 19 0 P13639 P13639 EEF2 Elongation factor 2 0 23205500.0 14485000.0 0.0 8720500.0 False True 12044919.294302756 0.0 10543916.23096366 1.0 0.0 0.8753828874512203 23.521921391196035 -9.081068291460216 11.913218260832647 0.9999999994220654 0.43769144372560187 0.3549068837407553 0.3573735673033112 0.0 0.0 0.34602546863510125 0.11534182287836707 8.297202863143527e-10 9.081068291460216 -0.5623085556964635 IWDILGDRPSLVHSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IWDILGDRPSLVHSR 15 1 Q13610;B4DJV5 Q13610 PWP1 Periodic tryptophan protein 1 homolog 0 13942000.0 5353900.0 2413500.0 6174600.0 False True 5183943.375076694 3377223.1362362336 4557287.025970577 1.0 0.6514776284928593 0.8791158961884212 22.305618528877304 -10.1485431460512 4.983855092656235 1.0000133961963018 0.7652967623400987 0.5863290297152377 0.09293293363274527 1.3833849651386827e-05 2.363479731529351e-06 0.08998705951821648 0.029993975355883398 7.103245975569135e-11 10.1485431460512 -0.23471663385620312 IWDILGDRPSLVHSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IWDILGDRPSLVHSR 15 1 Q13610;B4DJV5 Q13610 PWP1 Periodic tryptophan protein 1 homolog 0 12835200.0 2705000.0 7793900.0 2336300.0 False True 4103682.7619891637 6403017.650981354 1874529.2809633345 1.0 1.5603100976250028 0.45679195729415994 21.96848777605006 -6.768667485649403 1.5794764469008507 1.3219286998451443 0.45088446949870814 0.7254537877902154 0.23606356624435604 0.2685956530658095 1.3222073656037532 0.11781770563246664 0.2808081732643942 1.7034622524759231e-07 6.768667485649403 -0.8710442303464361 down IWDILGDRPSLVHSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IWDILGDRPSLVHSR 15 1 Q13610;B4DJV5 Q13610 PWP1 Periodic tryptophan protein 1 homolog 0 11192100.0 2934600.0 3619300.0 4638200.0 False True 4019600.9245830853 3459387.3585754167 3542752.6867274907 1.0 0.8606295558891149 0.8813692585900046 21.938620843687435 -10.030493886333769 6.863529489643049 1.000000028599471 0.8709994072534961 0.9809828891091678 0.008466948172367553 3.7024065101980206e-09 5.339573675619149e-10 0.008198089026447867 0.002732695772064987 9.321935929591265e-11 10.030493886333769 -0.1290006213459749 IWDILGDRPSLVHSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IWDILGDRPSLVHSR 15 1 Q13610;B4DJV5 Q13610 PWP1 Periodic tryptophan protein 1 homolog 0 8304600.0 5353900.0 1139800.0 1810900.0 False True 4452005.067985328 1133659.671167415 2189550.81734443 1.0 0.2546402472269493 0.491812292193834 22.08602380431158 -10.169981043449143 5.292248618741069 1.0000253772237835 0.3732262697117037 0.9030236539754026 0.09682508190438854 2.8992916474347356e-05 4.546974586772101e-06 0.09375426893152768 0.03125016080911773 6.761124864301193e-11 10.169981043449143 -0.6267991075120798 IWGLDFGDCHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IWGLDFGDCHK 11 0 Q9UNX4 Q9UNX4 WDR3 WD repeat-containing protein 3 0 3530740.0 894760.0 980180.0 1655800.0 False True 1173039.0248681665 833940.9647117144 1484473.699555142 1.0 0.7109234620778605 1.265493873677371 20.161819579320817 -6.76504495069293 1.5932505022278995 0.8331422555597652 1.2680559650798422 0.7112627910790701 0.12169235518954268 0.27454538135329615 1.3745409677017593 0.0602306942296941 0.14404552345061997 1.7177305880386832e-07 6.76504495069293 0.434913709520077 IWGLDFGDCHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IWGLDFGDCHK 11 0 Q9UNX4 Q9UNX4 WDR3 WD repeat-containing protein 3 0 2989170.0 894760.0 1115100.0 979310.0 False True 1225576.9519798143 1065831.1948574153 748017.1475225523 1.0 0.8696566895580539 0.610338784777402 20.225029640843708 -6.960147681816163 0.4333476924632946 1.0099421360214922 0.46005376358293354 0.9997756356474231 0.002425916114491446 0.07964841023361499 0.02093671816987507 0.003392872086342824 0.021515207257554986 1.0961054021770388e-07 6.960147681816163 -0.5498883724385586 IWHHTFYNELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IWHHTFYNELR 11 0 C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;Q9BYX7;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;A6NL76;Q6S8J3;A5A3E0;P0CG38;P0CG39 C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG1;POTEKP;ACTA1;ACTC1;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 978027800.0 280158800.0 312099000.0 385770000.0 False True 367290899.8616782 265535045.75237387 345854220.96713793 1.0 0.7229556894885618 0.9416356928456073 28.45234791085301 -9.889445608595956 5.740712838071515 1.000000070659389 0.8322956916215006 0.4395146176664495 0.08927573753012 8.075311816068267e-08 1.5594036357953862e-08 0.08644089723408149 0.02881362038940292 1.2898950953232674e-10 9.889445608595956 -0.16770437903788837 IWHHTFYNELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IWHHTFYNELR 11 0 C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;Q9BYX7;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;A6NL76;Q6S8J3;A5A3E0;P0CG38;P0CG39 C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG1;POTEKP;ACTA1;ACTC1;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 1291391500.0 506004900.0 231065800.0 554320800.0 False True 489942051.4225786 323331578.93222886 409127553.21245605 1.0 0.6599384110700738 0.835052945597398 28.868035881654997 -10.191811516988396 5.317477289465167 1.0000127275501565 0.7474956783336707 0.734906036734907 0.07149020935638341 1.0787490180612111e-05 1.6396453727722276e-06 0.0692235843818661 0.02307336585447994 6.42966703147308e-11 10.191811516988396 -0.25251704921648577 IWHHTFYNELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IWHHTFYNELR 11 0 C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;Q9BYX7;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;A6NL76;Q6S8J3;A5A3E0;P0CG38;P0CG39 C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG1;POTEKP;ACTA1;ACTC1;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 1168623200.0 387148300.0 454161700.0 327313200.0 False True 587332275.4319438 373112996.25344205 262619602.5535281 1.0 0.6352673126622274 0.44713974276381946 29.12960167894716 -12.54006367824799 0.09775418832061039 2.413750422576628 5.263953605016451e-23 0.9998500307514963 0.0028106262342308445 7.103894276590109 0.07753411695634613 2.3681285746132743 0.35166876927432716 2.8836086642056265e-13 12.54006367824799 -2.413750422576628 IWHHTFYNELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IWHHTFYNELR 11 0 C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;Q9BYX7;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;A6NL76;Q6S8J3;A5A3E0;P0CG38;P0CG39 C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG1;POTEKP;ACTA1;ACTC1;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 1298193400.0 280158800.0 396408800.0 621625800.0 False True 383741079.36689377 378894148.4673972 474810588.82521814 1.0 0.9873692675605824 1.2373201993609162 28.515557972375902 -6.895002291566424 0.9923331953668536 0.9881355843761588 1.2610482386367556 0.9839112402209563 0.01458253252760848 0.11517775982302213 0.19889576531390651 0.011116923709883878 0.028262902731109256 1.2734963613613957e-07 6.895002291566424 0.27291265426059685 IWHHTFYNELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IWHHTFYNELR 11 0 C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;Q9BYX7;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;A6NL76;Q6S8J3;A5A3E0;P0CG38;P0CG39 C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG1;POTEKP;ACTA1;ACTC1;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 1161213400.0 506004900.0 438414700.0 216793800.0 False True 420765494.16787905 436052872.9925954 262124381.23872355 1.0 1.036332301570853 0.6229702408395207 28.648441157089273 -6.885478407408581 1.0487299241731618 1.024676947975138 0.590410036964236 0.9778440591815921 0.027817841602598387 0.12288978576492808 0.24387691040804763 0.02032085188659727 0.04990337456577394 1.3017320344978766e-07 6.885478407408581 -0.4342669110109021 IWHHTFYNELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IWHHTFYNELR 11 0 C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;Q9BYX7;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;A6NL76;Q6S8J3;A5A3E0;P0CG38;P0CG39 C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG1;POTEKP;ACTA1;ACTC1;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 2296808700.0 387148300.0 1165479000.0 744181400.0 False True 501171106.18390423 1100619069.1116216 608748021.1459831 1.0 2.1960944187148543 1.2146510715296577 28.90072800103961 -6.597292211648243 2.201185116744446 1.8058219123408281 1.2177638530327033 0.012740639984889834 0.5173502451987321 0.6484708339634317 5.934060857806003 0.19540147189022095 0.5757037516613793 2.527596750454299e-07 6.597292211648243 -0.5880580593081248 IWHPNISSVTGAICLDILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IWHPNISSVTGAICLDILK 19 0 P61086;P61086-2;P61086-3 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 0 140040000.0 41545000.0 37030000.0 61465000.0 False True 63026802.34633627 30421707.18328948 49316415.80893345 1.0 0.48267889295922506 0.7824673626616281 25.909462133922755 -10.226592054631775 5.740432753079103 1.0000133497955521 0.632573127810423 0.6669842049638293 0.12238813025680842 2.0911118544703906e-05 2.817296864073096e-06 0.11850610073664625 0.03950059918816999 5.934825381493715e-11 10.226592054631775 -0.36744022198512916 IWHPNISSVTGAICLDILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IWHPNISSVTGAICLDILK 19 0 P61086;P61086-2;P61086-3 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 0 92242000.0 41545000.0 19425000.0 31272000.0 False True 53780821.47438151 18343981.674052656 25580816.877816595 1.0 0.34108779247246734 0.4756494262550827 25.680588456015204 -9.863346968331738 6.667545593853341 1.0000000156086521 0.4083686093668023 0.9626517250520448 0.05493455695386811 1.2776862793284213e-08 2.1397248258624673e-09 0.05319015843114537 0.01773005201778772 1.3697869730586316e-10 9.863346968331738 -0.5916314062418498 IWHYTGSILHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IWHYTGSILHK 11 0 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;Q9BY44-2;H7C5R5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 206983000.0 41281000.0 71964000.0 93738000.0 False True 54119790.76577269 61227251.713474914 84038890.95838845 1.0 1.1313283153377829 1.5528310396118101 25.68965292588804 -6.949923599873814 0.559679986537305 0.9944780581996585 1.7098145863072016 0.9991952862047236 0.006689844536657016 0.08351640247353899 0.03608918194879502 0.007173905948875377 0.03503587905184516 1.1222158546732547e-07 6.949923599873814 0.7153365281075431 IWHYTGSILHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IWHYTGSILHK 11 0 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;Q9BY44-2;H7C5R5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 51630000.0 30805000.0 20825000.0 0.0 False True 29827112.136804495 29140531.100940324 0.0 1.0 0.9769813104025924 0.0 24.830120966806035 -7.041869392239405 1.061874171913796 1.0151363506796713 6.663474507209794e-19 0.9873535207272501 0.052413048859081136 0.0858613995930951 0.18690558708325503 0.04145439607701451 0.07448911588764705 9.080935850800122e-08 7.041869392239405 -1.0151363506796713 down IWHYTGSILHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IWHYTGSILHK 11 0 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;Q9BY44-2;H7C5R5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 52546000.0 18204000.0 14114000.0 20228000.0 False True 27616798.89066573 11595246.426814662 16229926.933752658 1.0 0.41986207281734483 0.5876831343852184 24.719042768304075 -10.82542742229545 10.866622833429913 1.0062902278735995 0.5037726036013818 0.9209957683596464 0.06851266148891506 0.010317595897238565 0.00016575211790569933 0.06555427243357284 0.0221123664125762 1.4947638209546266e-11 10.82542742229545 -0.5025176242722177 IWHYTGSILHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IWHYTGSILHK 11 0 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;Q9BY44-2;H7C5R5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 141950000.0 41281000.0 56385000.0 44284000.0 False True 56543701.27707844 53893724.2597394 33825031.25760862 1.0 0.9531340015335487 0.5982104194392477 25.752862987410932 -6.9311314457943185 0.7374479132069657 1.0051771950370052 0.5232021968035189 0.9967559148013697 0.010217052118324724 0.09205474338613755 0.07483386194078714 0.009371634323271068 0.03191704748466878 1.1718406365742465e-07 6.9311314457943185 -0.48197499823348633 IWHYTGSILHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IWHYTGSILHK 11 0 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;Q9BY44-2;H7C5R5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 76394000.0 30805000.0 24724000.0 20865000.0 False True 25615722.392888933 24590806.904670224 25227775.03114008 1.0 0.9599888118516138 0.9848551075078582 24.61052624224031 -9.981232501714539 4.366322821493241 1.000000794242537 0.9724219596867479 0.6212117760265309 0.010151622717577233 13966623.433246672 2.197525710065023 137.94486058785031 0.0034751704697433775 1.0441610727309361e-10 9.981232501714539 -0.027578834555789133 IWHYTGSILHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IWHYTGSILHK 11 0 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;Q9BY44-2;H7C5R5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 112037000.0 18204000.0 54438000.0 39395000.0 False True 23565436.854486533 51408477.445152014 32225514.22683501 1.0 2.181520239263655 1.3674906357910237 24.490169090396524 -10.198135991231915 6.395603472135856 0.9999942373766786 1.7745054375273401 0.5468962453344833 0.3323261940046807 2.7307070533457846e-05 3.42394091515909e-06 0.32177584399137704 0.10725781790738494 6.336712578299747e-11 10.198135991231915 0.7745112001506615 IWLAAHWDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IWLAAHWDK 9 0 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7 O60216 RAD21 Double-strand-break repair protein rad21 homolog 0 4693300.0 2014100.0 1196200.0 1483000.0 False True 1950163.4979626024 1673848.8981005906 1094557.810953643 1.0 0.8583120850376461 0.5612646386301262 20.895163651151265 -6.959112852397786 0.4477614218556753 1.009801389009248 0.39804335641696115 0.9997358671019995 0.0029711807814833927 0.08001956227383801 0.022313832577445097 0.003957364331803802 0.024579139591606576 1.0987202973946207e-07 6.959112852397786 -0.6117580325922869 IWLAAHWDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IWLAAHWDK 9 0 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7 O60216 RAD21 Double-strand-break repair protein rad21 homolog 0 15558100.0 3984300.0 5628800.0 5945000.0 False True 6044474.391346929 4624296.661984864 4769968.144213935 1.0 0.7650452897285586 0.7891452317247741 22.5271854619887 -10.1099320591965 7.23088020153849 1.0000000816854109 0.7770952607266663 0.9913091169996044 0.00983876012023331 1.2952827183714387e-08 1.5999738199776368e-09 0.009526341930115614 0.003175446174416103 7.763685618241754e-11 10.1099320591965 -0.22290482095874453 IWLAAHWDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IWLAAHWDK 9 0 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7 O60216 RAD21 Double-strand-break repair protein rad21 homolog 0 7366100.0 2760700.0 2189300.0 2416100.0 False True 3781405.395112285 2092569.486953045 1845466.9411414545 1.0 0.5533840644692126 0.488037316371009 21.850491094704914 -13.999999999999998 0.2706756416358451 4.459683356315561 0.46648800089068054 0.9995847822762256 0.004635916114443238 14.916194493350261 0.1647003209327229 28.40858719433195 0.027048494167196714 1.0000000000000041e-14 13.999999999999998 -3.9931953554248807 IWLAAHWDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IWLAAHWDK 9 0 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7 O60216 RAD21 Double-strand-break repair protein rad21 homolog 0 5194200.0 2014100.0 1254300.0 1925800.0 False True 1674813.3897587284 1247542.8369409433 2328475.876106856 1.0 0.7448846806274118 1.3902897423349914 20.67556892658554 -6.799477791358023 1.4581887832055767 0.8591490254679602 1.399070153156641 0.830594577284962 0.10923768958934077 0.22150284666866935 0.9299164665712131 0.05893740530312988 0.13710165794725301 1.58680006152852e-07 6.799477791358023 0.5399211276886807 IWLAAHWDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IWLAAHWDK 9 0 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7 O60216 RAD21 Double-strand-break repair protein rad21 homolog 0 21215800.0 3984300.0 10025000.0 7206500.0 False True 5157754.892294589 9467099.937316766 5894990.944934295 1.0 1.8355079167216939 1.1429373958311002 22.29831178408115 -10.132215601529088 4.28819927940236 0.9999098150952387 1.489222656305079 0.39951109321633693 0.28274073132737154 98719873.72223005 16.898112069962803 90608.13349345376 0.096789672774044 7.375379952279101e-11 10.132215601529088 0.4893128412098403 IWNLEGVQTAHFVLHSPGMSVCWHPEETFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IWNLEGVQTAHFVLHSPGMSVCWHPEETFK 30 0 Q8NFH4;H0YHK8 Q8NFH4 NUP37 Nucleoporin Nup37 0 99281800.0 25894900.0 24754000.0 48632900.0 False True 39284456.47077016 20336455.296115223 39020585.99844273 1.0 0.5176718000730566 0.9932830820117428 25.22745526401667 -10.93548032780695 10.65256797636748 1.0502364264247135 0.7554774410424 0.26058994607088015 0.194167492776795 0.11106303834404035 0.0006726773310283883 0.09013225444445966 0.06266728882494797 1.1601647668234979e-11 10.93548032780695 -0.2947589853823135 IWNLEGVQTAHFVLHSPGMSVCWHPEETFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IWNLEGVQTAHFVLHSPGMSVCWHPEETFK 30 0 Q8NFH4;H0YHK8 Q8NFH4 NUP37 Nucleoporin Nup37 0 65636500.0 25894900.0 20234600.0 19507000.0 False True 33521458.514790334 19108526.722357046 15956926.158722436 1.0 0.5700386429762889 0.47602123731227036 24.99858158610912 -13.999999999999993 0.21363603851403057 3.524537265230481 0.4225583466677578 0.9994923625417266 0.005139238023339168 12.834250395073909 0.1464735575620126 13.624311758534976 0.054305693101189094 1.0000000000000164e-14 13.999999999999993 -3.1019789185627236 IWNLSENSTSGSTQLVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IWNLSENSTSGSTQLVLR 18 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 3903800.0 1764200.0 2139600.0 0.0 False True 2312883.2845371007 1820380.0200954776 0.0 1.0 0.7870609088948505 0.0 21.14126103414477 -7.271273881046328 0.8378797375160772 0.9890495199814223 2.1711779025700563e-17 0.9885888511475649 0.0459436500422603 0.1007796841052233 0.1377186484206732 0.039031114051324374 0.06886459999025553 5.354588722226334e-08 7.271273881046328 -0.9890495199814223 down IWNLSENSTSGSTQLVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IWNLSENSTSGSTQLVLR 18 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 14572900.0 6776600.0 2787400.0 5008900.0 False True 6561480.542323305 3900423.356098976 3696918.826220976 1.0 0.594442569926132 0.563427537790421 22.64558995277541 -13.999999999999998 0.36461375773361615 6.461471883419617 0.5599363085473291 0.9997815372362593 0.002939764389678742 22.204029815371577 0.19553080596426647 94.5589462238631 0.008817260763277398 1.0000000000000041e-14 13.999999999999998 -5.9015355748722875 IWNLSENSTSGSTQLVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IWNLSENSTSGSTQLVLR 18 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 43529700.0 7428700.0 25114000.0 10987000.0 False True 11269881.010716794 20632210.4834224 8815414.634226825 1.0 1.8307389815209891 0.7822100895159444 23.42596894758724 -6.695531247463686 1.8465724673902097 1.5180854762341713 0.7855514844824826 0.39653706327635063 0.3509581871709319 0.40487536621306164 2.680692515001534 0.15180129497472286 0.39259475217656886 2.0158989216316136e-07 6.695531247463686 -0.7325339917516888 IWNLSENSTSGSTQLVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IWNLSENSTSGSTQLVLR 18 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 7132400.0 1764200.0 1662400.0 3705800.0 False True 2416472.4157123533 1588949.6711783395 2830566.3633467173 1.0 0.6575492692764432 1.1713629938177021 21.20447109566766 -6.727037848268725 1.7337913083840792 0.7932388905155208 1.1709086797743558 0.545562200302338 0.1439951361744239 0.3418312788154758 2.0116280905911665 0.06584959884766296 0.1639670795207498 1.8748311115547453e-07 6.727037848268725 0.377669789258835 IWNLSENSTSGSTQLVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IWNLSENSTSGSTQLVLR 18 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 0 12622300.0 6776600.0 2933100.0 2912600.0 False True 5635043.154281812 2917298.808125235 3521611.193659168 1.0 0.517706560225455 0.6249483983069867 22.425995228209686 -10.020473484608468 6.100824458226051 1.0000004531127742 0.5713274792662321 0.9551650290267352 0.04378129706307019 2.6980551315014054e-07 4.327958076014772e-08 0.04239110344738578 0.014130352866707113 9.539519835958159e-11 10.020473484608468 -0.4286729738465421 IWNNVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IWNNVTR 7 0 P26640;A0A140T936;A0A140T954 P26640 VARS Valine--tRNA ligase 0 6672500.0 1208400.0 3104200.0 2359900.0 False True 1584224.102162248 2641065.4600768285 2115720.1857592566 1.0 1.667103446079464 1.3354929917248384 20.59534500083354 -10.022686095545849 4.390457590162611 0.9999749257864675 1.5012982188073567 0.7529043169858458 0.13537940136012078 31171467.84392109 51351304.46165271 10603.149157989763 0.04954378697916644 9.491042201100024e-11 10.022686095545849 0.5013232930208892 IWNNVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IWNNVTR 7 0 P26640;A0A140T936;A0A140T954 P26640 VARS Valine--tRNA ligase 0 6107600.0 1208400.0 2130900.0 2768300.0 False True 1655178.1357821182 2036749.7920560201 2114484.5549281407 1.0 1.2305320787080107 1.2774966689183502 20.65855506235643 -13.236721970242314 0.2338016865300373 1.2164357557104422e-07 1.3001535315312422 0.999471761553105 0.002787168209468 9.413587247750401 0.14927106169497004 4.379370477014357 0.02382115128181713 5.797997580091849e-14 13.236721970242314 1.3001534098876666 IWNVHSVLNVLHSLVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IWNVHSVLNVLHSLVDK 17 0 B0QY89;Q9Y262;Q9Y262-2;B0QY90 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 12297482900.0 4573183400.0 3588999500.0 4135300000.0 False True 6937853562.290196 2948514498.2439156 3317956142.433625 1.0 0.4249894397123318 0.47823957548887247 32.6918422438773 -10.588129717178976 10.013253827417712 1.0000412025666914 0.4516145085270351 0.9929778455395237 0.02173927689774134 1.9997636711252483e-05 8.225627724047857e-07 0.021050526820117897 0.0070163214486286644 2.581489023829615e-11 10.588129717178976 -0.5484266940396563 IWNVHSVLNVLHSLVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IWNVHSVLNVLHSLVDK 17 0 B0QY89;Q9Y262;Q9Y262-2;B0QY90 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 570582000.0 72098000.0 229545000.0 268939000.0 False True 59952681.4829575 228308395.52388468 325172901.46655995 1.0 3.8081431868695477 5.423825814346528 25.83732094621884 -8.530873040934623 0.28942389129064083 4.551327446191603e-20 6.348370951153174 0.9988676264890586 0.06150548227859721 0.18588644104512173 0.08162284480453395 0.6945671747889262 0.5414140085703305 2.9452825143300934e-09 8.530873040934623 6.348370951153174 IWNVHSVLNVLHSLVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IWNVHSVLNVLHSLVDK 17 0 B0QY89;Q9Y262;Q9Y262-2;B0QY90 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 12128983400.0 4573183400.0 4497000000.0 3058800000.0 False True 5920076062.221841 4246737996.819306 2502129785.938392 1.0 0.7173451746539687 0.4226516280602191 32.46296856596976 -6.970600672819912 0.24342439283203954 1.1014227047728804 0.03001430841668754 0.9999866922311388 0.0008598775789096124 0.07610837964217386 0.008330269359632816 0.0068767933028061915 0.028557476863857297 1.0700383110034087e-07 6.970600672819912 -1.071408396356193 down IWPLHPSLLGEPHCFQVTWTGGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IWPLHPSLLGEPHCFQVTWTGGSR 24 0 Q86YV0;Q86YV0-2 Q86YV0 RASAL3 RAS protein activator like-3 0 54894000.0 16131000.0 12929000.0 25834000.0 False True 24471906.334065534 10621718.935261935 20727898.576555543 1.0 0.43403725031736595 0.8470079238453837 24.54462315433251 -9.85666235439217 6.992316262147438 1.0000000036399321 0.6405225870813848 0.5025578775046811 0.1685945714795386 9.37784533499869e-09 1.7393953011174105e-09 0.1632409943327803 0.05441366396676683 1.391033680830059e-10 9.85666235439217 -0.35947741655854737 IWPLHPSLLGEPHCFQVTWTGGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IWPLHPSLLGEPHCFQVTWTGGSR 24 0 Q86YV0;Q86YV0-2 Q86YV0 RASAL3 RAS protein activator like-3 0 47999000.0 16131000.0 12397000.0 19471000.0 False True 20881897.48954748 11707096.052161172 15927477.789331261 1.0 0.5606337287126903 0.7627409241570995 24.31574947642496 -10.22262993985996 5.996178942053481 1.0000073802010263 0.6616873264348931 0.7888532115491275 0.08250991703063236 8.140626118886365e-06 1.0554586754746438e-06 0.0798916256447612 0.026629961213048618 5.989217158704745e-11 10.22262993985996 -0.33832005376613317 IWPYVYAFLQTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IWPYVYAFLQTK 12 0 Q9UIJ7-2;Q9UIJ7-3;Q9UIJ7 Q9UIJ7-2 AK3 GTP:AMP phosphotransferase AK3, mitochondrial 0 9568000.0 0.0 5071300.0 4496700.0 False True 0.0 4789077.696969017 3678346.7400383023 0.0 IWSVPNASCVQVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IWSVPNASCVQVVR 14 0 Q9UMS4 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 68113000.0 23400000.0 18575000.0 26138000.0 False True 30677626.605922323 15803682.4047829 23433490.493400324 1.0 0.5151533594105352 0.7638625632426363 24.870683536351088 -10.514302672083826 7.6153169053849075 1.0000721361850582 0.6395079613265985 0.7369261898871828 0.10153510728708375 0.00012437951541107 7.932783910240789e-06 0.09833046024011607 0.032770314964854864 3.0598302083785814e-11 10.514302672083826 -0.3605641748584597 IWSVPNASCVQVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IWSVPNASCVQVVR 14 0 Q9UMS4 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 24019800.0 10480000.0 3859600.0 9680200.0 False True 10147318.136461977 5400758.407548107 7144665.220224856 1.0 0.5322350531360365 0.7040939412899847 23.274595148028805 -10.099755591341827 4.9484673688193626 1.000013398192769 0.6181644972111783 0.8681059030376153 0.0701610972962119 18908454.2535431 38591902.577641584 1814.824183201399 0.024018010098393352 7.947753860116856e-11 10.099755591341827 -0.38184890098159074 IWSVPNASCVQVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IWSVPNASCVQVVR 14 0 Q9UMS4 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 52628400.0 8488100.0 35567000.0 8573300.0 False True 12877068.263231141 29219790.96376063 6878783.497189114 1.0 2.2691338095328804 0.5341886333576891 23.618300835028954 -6.710627924797905 1.7932100326302567 1.7797391102732083 0.5382296220406332 0.4680035521154742 0.534753060937914 0.3737989922147712 2.343513722686064 0.23729153974732542 0.6023185402629084 1.9470274534757703e-07 6.710627924797905 -1.241509488232575 IWSVPNASCVQVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IWSVPNASCVQVVR 14 0 Q9UMS4 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 60671000.0 23400000.0 17599000.0 19672000.0 False True 32051612.361222688 16821417.98788955 15025878.757557493 1.0 0.5248228325711555 0.4688025859109789 24.93389359787398 -13.999999999999998 0.3016684266453818 5.376245279833008 0.45525555760555214 0.9996535499843547 0.004435602180797873 16.697904124744138 0.1744804932909715 45.65489091401622 0.02010113842427679 1.0000000000000041e-14 13.999999999999998 -4.920989722227456 IWSVPNASCVQVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IWSVPNASCVQVVR 14 0 Q9UMS4 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 22686800.0 10480000.0 2658700.0 9548100.0 False True 8714584.342719562 2644377.055389371 11544563.564573605 1.0 0.30344270608827906 1.3247405855011658 23.05500042346308 -6.72308924005133 1.7482158329207744 0.5776244832268581 1.3234293170556137 0.5270322185044294 0.2930086189633508 0.3493573144304468 2.088295192650815 0.13299639753166373 0.3326616746953074 1.8919548145048062e-07 6.72308924005133 0.7458048338287556 IWSVPNASCVQVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IWSVPNASCVQVVR 14 0 Q9UMS4 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 31154100.0 8488100.0 12299000.0 10367000.0 False True 10988012.775465121 11614549.838310095 8480312.374402804 1.0 1.057020052274052 0.7717785324511359 23.389427157121403 -6.854721907911509 1.2120068070974508 1.0306008128018505 0.759288294175827 0.9469064807560681 0.028397639411882152 0.15234103569652882 0.4282556949753201 0.01830881881352562 0.04251822281500879 1.3972627849154195e-07 6.854721907911509 -0.27131251862602346 IWTHPGWSPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IWTHPGWSPLK 11 0 O43172-2;O43172 O43172-2 PRPF4 U4/U6 small nuclear ribonucleoprotein Prp4 0 6309100.0 1254400.0 2680200.0 2374500.0 False True 1718185.5788853767 2561779.901763827 1813692.0043625613 1.0 1.4909797481979263 1.055585628613611 20.7124544377437 -10.136356046524654 4.58320632349421 0.999971351850476 1.2732826884078656 0.3443863072678759 0.17774890501829096 124173972.65669145 2.3586340863147273 39424.64911169196 0.06084817802846927 7.305399212532573e-11 10.136356046524654 0.2733113365573896 IWTHPGWSPLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IWTHPGWSPLK 11 0 O43172-2;O43172 O43172-2 PRPF4 U4/U6 small nuclear ribonucleoprotein Prp4 0 5224100.0 1897300.0 2192100.0 1134700.0 False True 1577689.0146413948 2180290.722202217 1371960.5237399768 1.0 1.3819521477100432 0.869601366941013 20.58938142660828 -6.707132686915452 1.8055092701600224 1.2355040137574589 0.8709091118550436 0.45140910681905344 0.1610271152237557 0.38088254557890716 2.418526171089774 0.07102364008031492 0.1810579209527753 1.9627605169087742e-07 6.707132686915452 -0.3645949019024153 IWTK(ub)DGNLASTLGQHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IWTKDGNLASTLGQHK 16 1 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 1 6632300.0 1634400.0 1797500.0 3200400.0 True False 1582516.86662533 2515251.1238386654 2362119.230058019 1.0 1.5893992518401168 1.4926344735239176 20.593789445449858 -10.68757004274211 6.533630845729038 0.9950806417211429 1.5410168626818568 0.9765697169950357 0.03950405532470303 0.0028409418588434833 0.00013585012367525246 0.03838687445146338 0.012749879031685913 2.0531938619324077e-11 10.68757004274211 0.5459362209607139 IWTK(ub)DGNLASTLGQHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IWTKDGNLASTLGQHK 16 1 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 1 12096600.0 2501400.0 2347100.0 7248100.0 True False 3794806.6768353777 1928241.6670240005 5815509.858044919 1.0 0.5081264557677095 1.5324917323310594 21.855594959978067 -6.7761619138456695 1.5510285422997836 0.7200925039735574 1.5396191642723824 0.7534765406903725 0.20769312738743165 0.256599928957705 1.2190180591634046 0.10550188388241462 0.24972961297166296 1.6743185395309707e-07 6.7761619138456695 0.819526660298825 IWTK(ub)DGNLASTLGQHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IWTKDGNLASTLGQHK 16 1 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 1 4831300.0 1634400.0 1238100.0 1958800.0 True False 1359076.0161966465 1231430.1095563918 2368376.023532093 1.0 0.9060789057278269 1.7426369057412676 20.374194720884134 -6.8790084003313146 1.085259450550179 0.9425114813724974 1.8008202589730051 0.9728791706784294 0.06162303400860798 0.12851465755644656 0.27759399969300463 0.043776962577150205 0.10560714545088865 1.3212700773024548e-07 6.8790084003313146 0.8583087776005077 IWTK(ub)DGNLASTLGQHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IWTKDGNLASTLGQHK 16 1 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 1 13756600.0 2501400.0 2704500.0 8550700.0 True False 3238111.609965534 2553992.1975534335 6994560.337591016 1.0 0.7887288967104559 2.1600738887642805 21.626721282070516 -6.867575446830262 1.1467762960876904 0.8820861213482594 2.236793906622931 0.9622065188044486 0.11719985291199492 0.13920447532822428 0.34365775055511144 0.07942287764135644 0.18729441313676987 1.3565148523430886e-07 6.867575446830262 1.3547077852746716 up IWVFGGANQSGNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IWVFGGANQSGNR 13 0 Q7Z6M1;Q5T1S4;Q5T1S5 Q7Z6M1 RABEPK Rab9 effector protein with kelch motifs 0 6654900.0 2411500.0 0.0 4243400.0 False True 3161499.8529992187 0.0 3804333.673567025 1.0 0.0 1.2033319153749034 21.592177721754855 -10.756499444255144 6.227392614351112 1.0121303647828341 0.6016659576874518 0.12747898801398827 0.49125819731241016 0.08275167020913424 0.0032357125412209834 0.47575187109246536 0.15855290140657008 1.7518646759804472e-11 10.756499444255144 -0.41046440709538234 IWVFGGANQSGNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IWVFGGANQSGNR 13 0 Q7Z6M1;Q5T1S4;Q5T1S5 Q7Z6M1 RABEPK Rab9 effector protein with kelch motifs 0 6766700.0 2411500.0 2117900.0 2237300.0 False True 3303096.7183371177 2024324.1750412725 1708895.8186398614 1.0 0.6128564639973306 0.5173617257868771 21.655387783277746 -13.999999999999988 0.19658458675160476 3.124723489342152 0.45321349475658396 0.9994871133634367 0.004726050848110236 12.465428951315635 0.1405995092232359 10.1697584473438 0.062391809433906535 1.0000000000000286e-14 13.999999999999988 -2.671509994585568 IYAMHWGTDSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYAMHWGTDSR 11 0 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1 P62873;P62879 GNB1;GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0 59436000.0 18028000.0 17516000.0 23892000.0 False True 23634882.583400358 14902681.076833237 21419885.028247036 1.0 0.6305375549993185 0.9062826926540776 24.49441436170832 -9.810507525495758 5.600359301669936 1.0000000504817426 0.7684101238247544 0.4846708265977221 0.11257248105813523 7.094103714816222e-08 1.5080843546095933e-08 0.10899786045473332 0.036332612030620694 1.5470076970203293e-10 9.810507525495758 -0.2315899266569882 IYAMHWGTDSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYAMHWGTDSR 11 0 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1 P62873;P62879 GNB1;GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0 28303000.0 9994500.0 6093500.0 12215000.0 False True 9677230.068212707 8526666.327182716 9015525.057854852 1.0 0.8811060879073954 0.9316224781581466 23.206162730593284 -10.109590621554712 4.416763806824923 1.000010932352208 0.9063642830273352 0.8208195818442615 0.020623229978676015 28738363.771337267 0.39075913394454226 3195.194694741712 0.007059880164730362 7.769791744185347e-11 10.109590621554712 -0.09364664932487277 IYAMHWGTDSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYAMHWGTDSR 11 0 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1 P62873;P62879 GNB1;GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0 33979700.0 13038000.0 15522000.0 5419700.0 False True 19779599.205476783 12751977.826060457 4348493.919461107 1.0 0.6447035500360166 0.21984742331164375 24.237509857238322 -7.421528916681636 0.3804284085983092 1.042102434782547 1.565180815315182e-21 0.9993290753049906 0.008260671825334357 0.11498517524259973 0.038560545205284 0.01628490740718344 0.060788892819996554 3.7885330767335595e-08 7.421528916681636 -1.042102434782547 down IYAMHWGTDSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYAMHWGTDSR 11 0 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1 P62873;P62879 GNB1;GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0 55335000.0 18028000.0 17230000.0 20077000.0 False True 24693438.78838134 16468721.628009403 15335226.098794335 1.0 0.6669270233742496 0.6210243227042888 24.55762442323121 -13.999999999999998 0.2792355978238662 3.7031144173818054 0.607101199150264 0.9996034864174804 0.003362732732471933 15.357018346819816 0.16738347627020808 23.695534291836992 0.018224024056046232 1.0000000000000041e-14 13.999999999999998 -3.0960132182315414 IYAMHWGTDSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYAMHWGTDSR 11 0 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1 P62873;P62879 GNB1;GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0 32198200.0 9994500.0 13641000.0 8562700.0 False True 8310869.5814227685 13567513.225473503 10353120.98054844 1.0 1.6325022421000175 1.2457325769725351 22.98656800602756 -10.042323824985402 4.23861174552893 0.9999632443812682 1.4391174090825707 0.6321745511270285 0.15789805498943713 15756925.242199868 6222012.821988849 5366.44410860406 0.05405270322416073 9.071438800929071e-11 10.042323824985402 0.43915416470130253 IYAMHWGTDSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYAMHWGTDSR 11 0 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1 P62873;P62879 GNB1;GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0 40253200.0 13038000.0 18622000.0 8593200.0 False True 16877948.017402496 17585669.329946395 7029325.773677849 1.0 1.0419317153847247 0.4164798805180618 24.00863617933077 -6.890858647643379 1.017266724183951 1.0329176704275544 0.3617668271846174 0.9814429941980002 0.03888805043678848 0.11845012538812172 0.21778938957355276 0.029093902490678475 0.07276100547516769 1.285705057770537e-07 6.890858647643379 -0.6711508432429371 down IYANFFPYGDASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYANFFPYGDASK 13 0 P37235;E9PC71;P84074 P37235 HPCAL1;HPCA Hippocalcin-like protein 1;Neuron-specific calcium-binding protein hippocalcin 0 25116200.0 8307000.0 7858800.0 8950400.0 False True 10890557.445102429 6686297.6733624665 8024298.466299263 1.0 0.613953666473643 0.7368124640771124 23.376574466081046 -10.78530860281082 10.362367531232199 1.0019349066134926 0.6753830652753781 0.9029904272752001 0.05015689409006214 0.0022506528807816344 4.662974494998616e-05 0.04874981857724944 0.016188067959025 1.639424410069135e-11 10.78530860281082 -0.32655184133811455 IYANFFPYGDASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYANFFPYGDASK 13 0 P37235;E9PC71;P84074 P37235 HPCAL1;HPCA Hippocalcin-like protein 1;Neuron-specific calcium-binding protein hippocalcin 0 23746600.0 8098200.0 2549400.0 13099000.0 False True 7841127.073730575 3567388.714945367 9667978.938423315 1.0 0.4549586661969642 1.2329833259319414 22.90262960973799 -6.718421541338586 1.7653357143598425 0.6678410998972867 1.231636973140451 0.5049283188899782 0.229400676989636 0.3583807730743737 2.18192014424823 0.10322239573453974 0.25957577572756274 1.9123987830488572e-07 6.718421541338586 0.5637958732431644 IYANFFPYGDASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYANFFPYGDASK 13 0 P37235;E9PC71;P84074 P37235 HPCAL1;HPCA Hippocalcin-like protein 1;Neuron-specific calcium-binding protein hippocalcin 0 24960700.0 8307000.0 7623100.0 9030600.0 False True 11378322.388234058 7286286.235779358 6897758.271045078 1.0 0.6403655993535446 0.6062192681565973 23.439784527603937 -13.999999999999998 0.33301280893638335 4.986707102920154 0.600383207344172 0.999721060352068 0.0029749961402633905 19.08111063562975 0.18470006168745084 53.36202351343875 0.010820712608383198 1.0000000000000041e-14 13.999999999999998 -4.386323895575982 IYANFFPYGDASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYANFFPYGDASK 13 0 P37235;E9PC71;P84074 P37235 HPCAL1;HPCA Hippocalcin-like protein 1;Neuron-specific calcium-binding protein hippocalcin 0 17731100.0 8098200.0 4401600.0 5231300.0 False True 6734012.111088892 4377887.707150811 6325140.643201681 1.0 0.6501158053965699 0.9392826355013643 22.683034885172265 -9.995409133427158 6.65042532221074 1.0000000427990439 0.7946992204489658 0.4019436046298067 0.11805186404914111 7.49774873670603e-08 1.1268913298577142e-08 0.11430324970822942 0.03810107528758814 1.0106269298765036e-10 9.995409133427158 -0.20530082235007807 IYAQK(ub)FIDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYAQKFIDR 9 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 21709000.0 2001200.0 4330800.0 15377000.0 True False 2590592.849549461 4089787.1729208417 12578543.78134387 1.0 1.5787070413755333 4.855469196377751 21.304850861533673 -6.937073230167165 0.6862490016007713 0.9606996334358292 5.6678897033443665 0.9977549117432712 0.0804364576553548 0.0891275209881601 0.060881860746547396 0.07666059942123844 0.2858501189635757 1.1559173164933769e-07 6.937073230167165 4.707190069908537 up IYDAQNELSAATHLTSKLLK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYDAQNELSAATHLTSKLLK 20 1 Q9UKG1;C9K0C4;C9JAB0 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 1 26175100.0 5716000.0 6913100.0 13546000.0 True False 5534548.708780211 9673536.881340241 9997896.228710752 1.0 1.747845649274671 1.8064519357919322 22.400034252699808 -11.211419549678336 0.43967110781553054 5.809206723898658e-19 1.8076248355039353 0.9996972529258099 0.006387956214257074 3.269207346378044 0.21605602485508074 3.221130236670503 0.013529223367522918 6.145828687732038e-12 11.211419549678336 1.8076248355039353 IYDAQNELSAATHLTSKLLK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYDAQNELSAATHLTSKLLK 20 1 Q9UKG1;C9K0C4;C9JAB0 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 1 8926680.0 873780.0 2271000.0 5781900.0 True False 1196840.0790166305 2170659.7108072722 4416334.301968372 1.0 1.8136589414608917 3.6899953296993537 20.190798962521967 -6.957168655568785 0.47366179465584174 0.9521638729006485 4.628885985511865 0.999650317359939 0.02106323743467074 0.08072860811485896 0.024990160993344737 0.02612527316142472 0.15482739068560433 1.1036499410597111e-07 6.957168655568785 3.676722112611217 IYDAQNELSAATHLTSKLLK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYDAQNELSAATHLTSKLLK 20 1 Q9UKG1;C9K0C4;C9JAB0 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 1 17523500.0 5716000.0 4730500.0 7077000.0 True False 4753107.261735207 4705015.857569269 8556767.979649087 1.0 0.9898821125807328 1.800247187463067 22.180439528134084 -6.904075308008045 0.9351606770965022 0.9699701984296417 1.8927085925005376 0.9884864278574769 0.04073666714091222 0.10846732287743337 0.16099219920713195 0.03240388210510859 0.08616927792446627 1.247167232831268e-07 6.904075308008045 0.9227383940708959 IYDLNK(ub)PEAEPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYDLNKPEAEPK 12 1 Q9Y3F4;Q9Y3F4-2 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 1 2725670.0 801420.0 1195800.0 728450.0 True False 1097726.6315611585 1142965.6020182038 556405.1128986765 1.0 1.041211508545354 0.5068703781991438 20.066087391978403 -6.888280791216436 1.032526052744247 1.0299053563598093 0.4624352624607745 0.9797738997295262 0.03452508818172363 0.12054802553028915 0.23009795707199404 0.025533837234315373 0.06327318884896682 1.293359355176015e-07 6.888280791216436 -0.5674700938990348 IYDLNK(ub)PEAEPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYDLNKPEAEPK 12 1 Q9Y3F4;Q9Y3F4-2 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 1 15814800.0 2966000.0 5128200.0 7720600.0 True False 3839545.468600692 4842811.161949898 6315530.020045759 1.0 1.2612980368519615 1.6448639745754672 21.872504101882964 -6.965614262800923 0.34735409237281134 0.9617861265854347 1.957266274717367 0.9999252472634099 0.002289766924308991 0.07775319414162167 0.014128780749320627 0.0053015353586738844 0.03302721443259913 1.0823948997559503e-07 6.965614262800923 0.9954801481319323 IYDYDPLYK(ub)EALQMLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYDYDPLYKEALQMLR 16 1 B0QYD3;Q9UH17-3;Q9UH17;P31941-2;P31941 B0QYD3 APOBEC3B;APOBEC3A DNA dC->dU-editing enzyme APOBEC-3B;DNA dC->dU-editing enzyme APOBEC-3A 1 5705170.0 3607300.0 1606200.0 491670.0 True False 4729205.2331428975 1366561.2209185623 440796.70483166806 1.0 0.28896213074905697 0.0932073536886296 22.173166321061256 -11.235157489284585 0.24342744331083216 2.1403982692712553 1.0697105197704798e-19 0.999241021068703 0.010733603473705852 3.4944748968100865 0.13631318666911998 2.254073523349433 0.09244356620319774 5.818921665073159e-12 11.235157489284585 -2.1403982692712553 IYDYDPLYK(ub)EALQMLR ddPTM_RPMI8226_Bortezomib_2h_R1 2 IYDYDPLYKEALQMLR 16 1 B0QYD3;Q9UH17-3;Q9UH17;P31941-2;P31941 B0QYD3 APOBEC3B;APOBEC3A DNA dC->dU-editing enzyme APOBEC-3B;DNA dC->dU-editing enzyme APOBEC-3A 1 143382100.0 75312400.0 37850300.0 30219400.0 True False 72921649.08592352 52964122.17670694 22304032.577432603 1.0 0.726315474767985 0.3058629756322677 26.119843851770458 -7.0042229737424035 0.36818513955149895 1.0339053134371115 2.9085948660777943e-13 0.9999085515994874 0.0027300384974351514 0.07391155099531858 0.015255881736755418 0.0055401319955038185 0.03397726475236645 9.90323366471027e-08 7.0042229737424035 -1.0339053134368206 down IYDYDPLYK(ub)EALQMLR ddPTM_RPMI8226_Bortezomib_8h_R1 2 IYDYDPLYKEALQMLR 16 1 B0QYD3;Q9UH17-3;Q9UH17;P31941-2;P31941 B0QYD3 APOBEC3B;APOBEC3A DNA dC->dU-editing enzyme APOBEC-3B;DNA dC->dU-editing enzyme APOBEC-3A 1 230424800.0 107378000.0 74967100.0 48079700.0 True False 162900276.38331684 61588635.28437429 38576726.220918894 1.0 0.3780756954607708 0.23681191387388992 27.27941381070022 -13.999999999999952 0.20825728374739225 4.571296732204306 0.1521882772943344 0.9994891073677142 0.007493518550610749 12.706474958456914 0.14465658821120442 18.55254962862399 0.0847112635341305 1.0000000000001104e-14 13.999999999999952 -4.4191084549099715 IYDYDPLYK(ub)EALQMLR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 IYDYDPLYKEALQMLR 16 1 B0QYD3;Q9UH17-3;Q9UH17;P31941-2;P31941 B0QYD3 APOBEC3B;APOBEC3A DNA dC->dU-editing enzyme APOBEC-3B;DNA dC->dU-editing enzyme APOBEC-3A 1 15878400.0 6030300.0 4472300.0 5375800.0 True False 8259864.872729965 4274698.998081622 4106146.7580763325 1.0 0.5175265048456892 0.49712033082197526 22.977686749390568 IYDYDPLYK(ub)EALQMLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IYDYDPLYKEALQMLR 16 1 B0QYD3;Q9UH17-3;Q9UH17;P31941-2;P31941 B0QYD3 APOBEC3B;APOBEC3A DNA dC->dU-editing enzyme APOBEC-3B;DNA dC->dU-editing enzyme APOBEC-3A 1 150078900.0 75312400.0 53096700.0 21669800.0 True False 62625597.50502217 52810657.53823023 26200854.99016529 1.0 0.8432759070122271 0.4183729342951842 25.900249127204734 -6.953701772288881 0.5166090491150639 1.0074141067667208 0.23538225907478877 0.9994606762145436 0.005706385895968545 0.08203248262973316 0.030067636315330205 0.006500067706362014 0.035086139834926124 1.1124954097247856e-07 6.953701772288881 -0.7720318476919321 down IYDYDPLYK(ub)EALQMLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IYDYDPLYKEALQMLR 16 1 B0QYD3;Q9UH17-3;Q9UH17;P31941-2;P31941 B0QYD3 APOBEC3B;APOBEC3A DNA dC->dU-editing enzyme APOBEC-3B;DNA dC->dU-editing enzyme APOBEC-3A 1 209025700.0 107378000.0 71726900.0 29920800.0 True False 139002937.73681885 67735234.96198754 24475521.413333796 1.0 0.48729354979701234 0.1760791664682261 27.05054013279267 -8.49124388629929 0.2876650143266917 1.1888035415534282 1.6626081988301984e-11 0.9989451188777304 0.011033108281336404 0.16510524736800325 0.0778277519826328 0.12219578127742152 0.10014940992769816 3.226681608608777e-09 8.49124388629929 -1.1888035415368021 IYEDGDDDMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYEDGDDDMK 10 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 4034330.0 987020.0 487810.0 2559500.0 False True 955687.5903674327 682595.0768955434 1889090.1666458843 1.0 0.714244993631346 1.9766816956570366 19.866179559706268 -6.847224621251012 1.2483946175528764 0.8477997043816669 2.0245154460938637 0.9361733837450783 0.13655276848506398 0.16053374588023037 0.4828475160798469 0.08564972529090435 0.1978806612497923 1.4215933353069442e-07 6.847224621251012 1.1767157417121967 IYEDGDDDMK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 2 IYEDGDDDMKR 11 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 22103670.0 9218100.0 8784700.0 4100870.0 True False 12085018.368207373 7474057.002492396 3676551.3107227245 1.0 0.6184564040179492 0.3042238909950523 23.52671633009133 -7.702322262363878 0.25256841699275784 1.1463024854814396 4.2091286432615654e-10 0.9997620789662706 0.004388198959300256 0.1277452618258991 0.0335380447073691 0.040412015510606934 0.07973329924094597 1.9846217090610146e-08 7.702322262363878 -1.1463024850605268 down IYEDGDDDMK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 2 IYEDGDDDMKR 11 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 29229120.0 11123320.0 11735100.0 6370700.0 True False 10770216.295197524 16420986.627738072 4702022.553096676 1.0 1.5246663741618862 0.43657642745701625 23.360543887619695 -6.775579475673256 1.5530060392457088 1.2987836976820648 0.4291088208295669 0.7514714376998494 0.2214976596064795 0.25750178778260724 1.226322771765076 0.1123701400324909 0.26615246231119505 1.67656549702528e-07 6.775579475673256 -0.8696748768524979 down IYEDGDDDMK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYEDGDDDMKR 11 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 23631400.0 7495700.0 11777000.0 4358700.0 True False 11371524.909072895 9675302.335879017 3497201.0345139257 1.0 0.8508359620405415 0.30754019909182506 23.4389223952441 -6.947029815985894 0.590560953986914 1.006269288314052 0.1247430291017932 0.9989470323597028 0.009655922104834713 0.084700988948052 0.04107202929388007 0.010004866752336436 0.04552223466408396 1.1297183525020849e-07 6.947029815985894 -0.8815262592122588 down IYEDGDDDMK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 2 IYEDGDDDMKR 11 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 19354550.0 9218100.0 6640400.0 3496050.0 True False 12626280.679785762 6347005.171133698 2670354.9934098646 1.0 0.5026820907993146 0.2114918130788119 23.58992639161422 -8.64296361678434 0.2513182603098754 1.2547980991374816 8.083929973544377e-26 0.999275260826095 0.00876420046545418 0.2331978075769032 0.07167584537175824 0.15965097171309015 0.1115239634666701 2.275288036067065e-09 8.64296361678434 -1.2547980991374816 down IYEDGDDDMK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYEDGDDDMKR 11 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 26824420.0 8519720.0 14737000.0 3567700.0 True False 7084524.667591089 14657608.855934516 4313689.574819 1.0 2.0689615102883763 0.6088890613300327 22.75623962885929 -6.710456816943468 1.793359374725091 1.6568819280736344 0.612250404787662 0.46725794923691655 0.45042585051161105 0.3742175573322698 2.3463222031436155 0.19984135833900502 0.5074511934338276 1.947794714727941e-07 6.710456816943468 -1.0446315232859724 IYEFPETDDEEENK(ub)LVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYEFPETDDEEENKLVK 17 1 E7ES33;E7EPK1;Q16181-2;Q16181;G3V1Q4 E7ES33 SEPT7 Septin-7 1 14008200.0 4094900.0 4961800.0 4951500.0 True False 5368453.5550680095 4221518.780944912 4439166.278141852 1.0 0.7863565806506139 0.8268985160449273 22.356075132443028 -10.396014366693919 5.878443031336698 1.000054437662191 0.8066275483477722 0.968085020908246 0.016551175816825456 1.1811738660217023e-05 1.2136453296889803e-06 0.01603010959248 0.005341869024892901 4.01777519613699e-11 10.396014366693919 -0.19342688931441876 IYEFPETDDEEENK(ub)LVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYEFPETDDEEENKLVK 17 1 E7ES33;E7EPK1;Q16181-2;Q16181;G3V1Q4 E7ES33 SEPT7 Septin-7 1 19839800.0 5781200.0 9495100.0 4563500.0 True False 5597678.970468882 13286542.946292376 3368182.4479345595 1.0 2.3735807316544713 0.601710542120001 22.416397319365917 -6.699732269265609 1.8316557572796324 1.853144181510993 0.6069751840564235 0.41641126053297994 0.5798313006441237 0.3960650929794764 2.583121826373604 0.25255501705289707 0.6497602661058749 1.9964927191272035e-07 6.699732269265609 -1.2461689974545695 IYEFPETDDEEENK(ub)LVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYEFPETDDEEENKLVK 17 1 E7ES33;E7EPK1;Q16181-2;Q16181;G3V1Q4 E7ES33 SEPT7 Septin-7 1 45470000.0 10785000.0 22731000.0 11954000.0 True False 16361633.489113916 18674475.451886386 9591286.66037568 1.0 1.1413576440464395 0.5862059351688307 23.9638134533837 -6.839181603937749 1.2861718289050157 1.0752090288435383 0.5682380800569629 0.9230427085246548 0.06534739880123647 0.1697550885533981 0.5458374550874935 0.0398450509218321 0.09177708342865604 1.4481661638967955e-07 6.839181603937749 -0.5069709487865754 IYEFPETDDEEENK(ub)LVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYEFPETDDEEENKLVK 17 1 E7ES33;E7EPK1;Q16181-2;Q16181;G3V1Q4 E7ES33 SEPT7 Septin-7 1 14789500.0 4094900.0 5847800.0 4846800.0 True False 5608895.190511577 5589424.859911397 3702085.662979345 1.0 0.9965286692051017 0.6600383029517235 22.41928519396592 -6.909156107995297 0.9014637061044465 1.0106985004193096 0.6173286526304913 0.9905991663561421 0.015459700690034679 0.10497866233911606 0.14181428339636765 0.012604488932724913 0.0345939248463924 1.2326616709533884e-07 6.909156107995297 -0.39336984778881834 IYEFPETDDEEENK(ub)LVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYEFPETDDEEENKLVK 17 1 E7ES33;E7EPK1;Q16181-2;Q16181;G3V1Q4 E7ES33 SEPT7 Septin-7 1 14947400.0 5781200.0 6906500.0 2259700.0 True False 4807323.950584947 6869293.313667083 2732192.8223276874 1.0 1.4289224908238687 0.5683396522498216 22.196802594800193 -6.771196893457738 1.5698408258703287 1.2456491005020653 0.5632782322366268 0.7350876177931787 0.18082934847819054 0.2645211748533487 1.2866797079506618 0.09078500889378725 0.21587234465263733 1.69356982288507e-07 6.771196893457738 -0.6823708682654386 IYEFPETDDEEENK(ub)LVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYEFPETDDEEENKLVK 17 1 E7ES33;E7EPK1;Q16181-2;Q16181;G3V1Q4 E7ES33 SEPT7 Septin-7 1 39530800.0 10785000.0 20722000.0 8023800.0 True False 13961395.104132999 19568802.483898018 6563550.731140477 1.0 1.4016366085152232 0.47012140851149364 23.73493977547615 -6.789552251926514 1.4983458420817173 1.2246045003399482 0.46036678534960696 0.7998055638375854 0.1706899215817321 0.2360182684303666 1.0468224699096014 0.08967411674800016 0.2099974905586858 1.6234830101734326e-07 6.789552251926514 -0.7642377149903412 down IYELAAGGTAVGTGLNTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYELAAGGTAVGTGLNTR 18 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 46625000.0 13157000.0 18117000.0 15351000.0 False True 17248954.41256926 15414014.219512897 13762625.777189845 1.0 0.8936202073953394 0.7978817410034468 24.040005576275107 -6.972376540456321 0.19317448802505024 1.0622551841737575 0.6266226640442965 0.9999954658767922 0.00017568826444450619 0.07553891153435342 0.006185907076970697 0.0032901880446296636 0.010346458940841845 1.065671765630224e-07 6.972376540456321 -0.4356325201294611 IYELAAGGTAVGTGLNTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYELAAGGTAVGTGLNTR 18 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 40054300.0 11500000.0 6937300.0 21617000.0 False True 11134938.794781735 9707400.067541586 15954859.203900797 1.0 0.8717964459841352 1.4328645624327871 23.40859029232309 -6.846612572335398 1.2512657434792265 0.9317333223086688 1.4538772756695757 0.9352361326289403 0.06108908373262955 0.16122473952827565 0.487448235057953 0.03823330011916673 0.08830683581154358 1.4235981916580362e-07 6.846612572335398 0.5221439533609069 IYELAAGGTAVGTGLNTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYELAAGGTAVGTGLNTR 18 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 96644400.0 6849000.0 81669000.0 8126400.0 False True 10390433.728969974 67094528.86719053 6520213.478072345 1.0 6.457336682695127 0.6275208184902891 23.30875254228174 -6.661041715241932 1.9692043120611777 4.509825272167232 0.6517933244586896 0.24002470143047205 2.3230371551839375 0.48198772864719264 3.5940436208292175 0.9527271723130842 2.5754877655240738 2.1825202643864433e-07 6.661041715241932 -3.8580319477085423 IYELAAGGTAVGTGLNTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYELAAGGTAVGTGLNTR 18 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 48868000.0 13157000.0 15503000.0 20208000.0 False True 18021498.45455588 14818026.198434679 15435286.59682402 1.0 0.8222416263442647 0.8564929623220061 24.103215637797998 -10.26903429156082 5.517418137268594 1.0000148864285447 0.839367294333132 0.9670249032574821 0.0139830493590362 2.5607641974482017e-06 3.3924461455647954e-07 0.013540283601641535 0.00451300977472575 5.382272828229844e-11 10.26903429156082 -0.1606475920954128 IYELAAGGTAVGTGLNTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYELAAGGTAVGTGLNTR 18 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 26426700.0 11500000.0 9108300.0 5818400.0 False True 9562759.536381187 9059231.780044 7035000.538757985 1.0 0.9473449317196012 0.7356663640859702 23.188995567757367 -6.94475973777829 0.6136892602121323 1.0023302589301346 0.6695875096647627 0.9987231793390238 0.004082015597139486 0.08566079831552509 0.04521496959557345 0.004134909632373412 0.0178727483824631 1.1356389048553429e-07 6.94475973777829 -0.33274274926537195 IYELAAGGTAVGTGLNTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYELAAGGTAVGTGLNTR 18 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 35379100.0 6849000.0 19295000.0 9235100.0 False True 8866165.513973748 18221216.288331848 7554406.560128036 1.0 2.055140551979752 0.85204889850316 23.07987886437419 -6.675074061993393 1.9196594016252286 1.6705509736745476 0.8568225842141626 0.3015619281559019 0.4476872108031062 0.449591287925974 3.198848070708071 0.18744158457591695 0.49745727861014993 2.1131286487384275e-07 6.675074061993393 -0.8137283894603851 IYEPLDVK(ub)SK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYEPLDVKSK 10 1 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 1 7765700.0 2203300.0 2088000.0 3474400.0 True False 2133357.4475254463 2921749.288776152 2564350.4102342147 1.0 1.3695544983168142 1.2020256676670342 21.024694281166635 -10.384837870155815 5.669375481741793 0.9999070044733562 1.285790082991925 0.795090296510998 0.06839335871618622 8.04180747365078e-05 8.725777487539051e-06 0.066243034822807 0.022073861608247737 4.122513911408259e-11 10.384837870155815 0.28588307851856887 IYEPLDVK(ub)SK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYEPLDVKSK 10 1 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 1 8659900.0 2203300.0 2614700.0 3841900.0 True False 1832141.5727398868 2600614.0921226824 4645223.527061443 1.0 1.4194394859091477 2.5354064315645193 20.80509955660091 -6.954113950338292 0.5116910449187811 0.9797438266832958 3.0242025687147587 0.9994858331981803 0.014692875450533256 0.08187465391671732 0.02944220137041901 0.0168743348818848 0.09211419811179777 1.1114400689859315e-07 6.954113950338292 2.0444587420314626 up IYFLLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYFLLVR 7 0 O75436;S4R3Q6;O75436-2;Q4G0F5 O75436;Q4G0F5 VPS26A;VPS26B Vacuolar protein sorting-associated protein 26A;Vacuolar protein sorting-associated protein 26B 0 8813600.0 2924400.0 3149100.0 2740100.0 False True 3833916.7199298833 2679266.555095656 2456580.736895183 1.0 0.6988327475054429 0.6407496344730489 21.870387568550093 -13.999999999999996 0.23140572551688093 2.9136315557311407 0.6128842139531373 0.9995117445659402 0.0034792584785666813 13.335465675671955 0.1523039211520969 11.734407580580347 0.029888909200586525 1.0000000000000082e-14 13.999999999999996 -2.3007473417780036 IYFLLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYFLLVR 7 0 O75436;S4R3Q6;O75436-2;Q4G0F5 O75436;Q4G0F5 VPS26A;VPS26B Vacuolar protein sorting-associated protein 26A;Vacuolar protein sorting-associated protein 26B 0 11071700.0 4800600.0 2863900.0 3407200.0 False True 4648207.580715584 4007470.205041199 2514752.1061909967 1.0 0.8621538809211821 0.5410154478952627 22.148243067709867 -6.956955224359486 0.47640895741851713 1.0079748348683997 0.38188633410838047 0.9996400763298792 0.003648160464584725 0.08080723072560092 0.025290166240268433 0.004495500110578151 0.02649516650074865 1.104192455969399e-07 6.956955224359486 -0.6260885007600192 IYFLLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYFLLVR 7 0 O75436;S4R3Q6;O75436-2;Q4G0F5 O75436;Q4G0F5 VPS26A;VPS26B Vacuolar protein sorting-associated protein 26A;Vacuolar protein sorting-associated protein 26B 0 24237900.0 7450400.0 7300800.0 9486700.0 False True 11302801.497199295 5997915.198589248 7611649.586831683 1.0 0.5306573949896813 0.6734303516449229 23.430177065629803 -10.781202009268908 10.526107224309612 1.001980359720013 0.6020438733173064 0.9119639672944085 0.058286815478973596 0.002716069930724135 5.645670942531259e-05 0.056586463167803705 0.01881198880446079 1.6549999718739968e-11 10.781202009268908 -0.3999364864027066 IYFLLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYFLLVR 7 0 O75436;S4R3Q6;O75436-2;Q4G0F5 O75436;Q4G0F5 VPS26A;VPS26B Vacuolar protein sorting-associated protein 26A;Vacuolar protein sorting-associated protein 26B 0 10982400.0 2924400.0 3106400.0 4951600.0 False True 4005629.708938447 2969148.976508898 3782134.0614030967 1.0 0.7412439971381599 0.9442046160590866 21.933597630072985 -9.88214018109361 5.565798464591224 1.0000000943797576 0.8427243068792992 0.4446425366854799 0.08285832570810359 9.708149606166821e-08 1.9438535017975727e-08 0.08022727730639156 0.026742409629864343 1.3117764169330746e-10 9.88214018109361 -0.15727578750045834 IYFLLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYFLLVR 7 0 O75436;S4R3Q6;O75436-2;Q4G0F5 O75436;Q4G0F5 VPS26A;VPS26B Vacuolar protein sorting-associated protein 26A;Vacuolar protein sorting-associated protein 26B 0 8605700.0 4800600.0 1547500.0 2257600.0 False True 3991911.602639264 1539163.3103453002 2729653.722036992 1.0 0.3855704894185728 0.6837961342210769 21.928648343144143 -10.510413178950463 6.3405839723719515 1.000366001004875 0.5346833118198691 0.7644831858428177 0.12175010966310558 0.0006303935478721662 4.867576203680114e-05 0.11797337515031862 0.039294678927011197 3.0873567863024006e-11 10.510413178950463 -0.4656826891850059 IYFLLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYFLLVR 7 0 O75436;S4R3Q6;O75436-2;Q4G0F5 O75436;Q4G0F5 VPS26A;VPS26B Vacuolar protein sorting-associated protein 26A;Vacuolar protein sorting-associated protein 26B 0 22127000.0 7450400.0 9094900.0 5581700.0 False True 9644689.669340061 8588760.819940366 4565887.873078434 1.0 0.8905170735812854 0.47340951649207963 23.201303387722252 -6.945995036050557 0.6012097903255978 1.004685897543201 0.3378444731968166 0.9988483105488484 0.0076994555163519 0.08513496469949522 0.04293356274050984 0.007892876558189882 0.03506651826022372 1.1324133065505456e-07 6.945995036050557 -0.6668414243463843 down IYFMAGSSR ddPTM_RPMI8226_Bortezomib_1h_R1 2 IYFMAGSSR 9 0 P14625 P14625 HSP90B1 Endoplasmin 0 759850500.0 214744200.0 225048000.0 320058300.0 False True 281531725.78579086 191471715.63023338 286941737.3320022 1.0 0.6801070646507474 1.0192163477530334 28.06872226774468 -11.039143586456163 12.401168977147911 1.4597225924644628 0.8496617062018904 0.2076438397714142 0.1384407851069344 0.042476493155838055 0.0001340748033527554 0.0032357504054876195 0.0446815712629197 9.138110672748913e-12 11.039143586456163 -0.6100608862625724 IYFMAGSSR ddPTM_RPMI8226_Bortezomib_2h_R1 2 IYFMAGSSR 9 0 P14625 P14625 HSP90B1 Endoplasmin 0 416366100.0 192133500.0 63400600.0 160832000.0 False True 186034327.21106085 88716790.20976114 118705274.34342295 1.0 0.4768839791008549 0.6380826384194606 27.470993612302134 -10.914157283049747 11.420787340373316 1.0462954427050084 0.5574833087601577 0.9094850398547777 0.06580907709188742 0.034538428940359515 0.0002596026956461605 0.02836951102089458 0.021239788300513325 1.218548212500863e-11 10.914157283049747 -0.4888121339448507 IYFMAGSSR ddPTM_RPMI8226_Bortezomib_8h_R1 2 IYFMAGSSR 9 0 P14625 P14625 HSP90B1 Endoplasmin 0 647781000.0 202035000.0 189419000.0 256327000.0 False True 306501865.73696166 155615699.51259792 205663856.09788463 1.0 0.5077153417596045 0.6710036025502837 28.19132061500931 -10.734562625157078 7.43269911494472 1.0043706463281112 0.5893594721549542 0.8939827110755099 0.06666215332061219 0.004852302271996602 0.0001732856896830584 0.06486932110462541 0.021515117469421374 1.8426267634878247e-11 10.734562625157078 -0.415011174173157 IYFMAGSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 IYFMAGSSR 9 0 P14625 P14625 HSP90B1 Endoplasmin 0 626613450.0 214744200.0 183536000.0 228333250.0 False True 294140933.98379827 175426772.6476108 174405639.02089614 1.0 0.5964038064055157 0.5929322269388818 28.13193232926757 IYFMAGSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 IYFMAGSSR 9 0 P14625 P14625 HSP90B1 Endoplasmin 0 410041740.0 192133500.0 121506240.0 96402000.0 False True 159767518.20724323 120851661.7680196 116559212.48751324 1.0 0.7564219756562549 0.7295551298250617 27.25139888773641 -13.999999999999945 0.31127791809902244 3.3721896188639926 0.7236863610362088 0.9996747998714582 0.002193777087698678 17.36119035181997 0.1775678176228558 26.693601791526426 0.009261831022446985 1.0000000000001268e-14 13.999999999999945 -2.648503257827784 IYFMAGSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 IYFMAGSSR 9 0 P14625 P14625 HSP90B1 Endoplasmin 0 1019393400.0 202035000.0 468374100.0 348984300.0 False True 261538290.2052398 442308669.60107607 285472738.2813065 1.0 1.691181315187074 1.0915141261238817 27.96244693710176 -10.516869681305332 4.214450774888098 0.9963989109366923 1.3913477206566671 0.36218928113276205 0.24481310478630172 0.008349379118847184 0.0009571438419093083 0.2389259483399434 0.07901308981367144 3.041797640609502e-11 10.516869681305332 0.3949488097199748 IYFQVFLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYFQVFLPK 9 0 E5RK75;E5RJ74;E5RGE5;E5RI74;Q8TCF1-2;Q8TCF1-4;Q8TCF1 E5RK75 ZFAND1 AN1-type zinc finger protein 1 0 1175900.0 0.0 1175900.0 0.0 False True 0.0 1123944.849818703 0.0 0.0 IYGADDIELLPEAQHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYGADDIELLPEAQHK 16 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 9998500.0 3624900.0 1266100.0 5107500.0 False True 3509829.5336699444 1771660.332624276 3769692.5282843774 1.0 0.5047710481744663 1.0740386369541757 21.74296953236081 -6.676734631661238 1.9130824662670183 0.6857388878548821 1.0718345442438622 0.3092101257155112 0.21004373728097883 0.4459465164961701 3.1525048094205044 0.08818262764825888 0.2335880096949319 2.1050643110136083e-07 6.676734631661238 0.38609565638898 IYGADDIELLPEAQHK(ub)AEVYTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYGADDIELLPEAQHKAEVYTK 22 1 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 1 8909900.0 1997900.0 3896000.0 3016000.0 True False 1661342.371977044 3875011.4747045515 3646631.655591588 1.0 2.332458101392538 2.1949910609045586 20.663917986064643 -10.278133588881815 5.976720623324406 0.9999387285113492 2.263724581148552 0.9912033697574089 0.05612068427435666 4.582127787350956e-05 5.534228375962048e-06 0.05434121380891065 0.018112872964360465 5.270677105799014e-11 10.278133588881815 1.2637858526372026 IYGFYDECK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYGFYDECKR 10 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;H0Y3Y6;P62140;E7ETD8;P62136;P62136-2;P62136-3 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 23234800.0 3160500.0 7777300.0 12297000.0 True False 4143446.1063255398 6616957.155677953 11024624.401153244 1.0 1.5969695238888852 2.660737974683112 21.982399726531423 -6.962238065630721 0.40265221528882367 0.9432067459751573 3.3535099884950084 0.9998444098660927 0.008567636388185642 0.07891112565935872 0.018246973841722223 0.013684902927741936 0.08903984279609099 1.0908422095102927e-07 6.962238065630721 2.410303242519851 IYGFYDECK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYGFYDECKR 10 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;H0Y3Y6;P62140;E7ETD8;P62136;P62136-2;P62136-3 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 6927600.0 2420000.0 1781100.0 2726500.0 True False 2343178.4246410266 2492302.5183138 2012347.8567532771 1.0 1.063641800429952 0.8588111923493694 21.160035383765948 -6.823227428722053 1.3577356211237626 1.0341952463908064 0.8540177933874145 0.8916757010732344 0.028171929990936977 0.18931548125069134 0.6848348771568169 0.016301048478841663 0.0375450745434323 1.5023550158171199e-07 6.823227428722053 -0.18017745300339194 IYGFYDECK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYGFYDECKR 10 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;H0Y3Y6;P62140;E7ETD8;P62136;P62136-2;P62136-3 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 136925600.0 8476500.0 40715000.0 87734100.0 True False 12859470.215157544 33449090.142253052 70393416.6797779 1.0 2.6011250527899965 5.4740526244078636 23.616327871907806 -6.962110322967583 0.40459456359531204 0.849856303722293 7.331006165420429 0.9998406375495462 0.023366298113392366 0.0789557063150234 0.018407943586705337 0.03696050668246929 0.24030494522968773 1.0911631152329848e-07 6.962110322967583 6.481149861698135 IYGFYDECK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYGFYDECKR 10 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;H0Y3Y6;P62140;E7ETD8;P62136;P62136-2;P62136-3 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 25414900.0 3160500.0 3444400.0 18810000.0 True False 4329022.259301044 3292215.0188923674 14367465.404110234 1.0 0.7604985194564285 3.318870761923497 22.045609788054314 -6.88397708146149 1.0573388912285944 0.842041450072558 3.5146202088440814 0.9767556430096124 0.1758985000006146 0.12416683525405285 0.2514758918529401 0.12765394384498055 0.3120764639762149 1.3062398190506972e-07 6.88397708146149 2.6725787587715235 up IYGFYDECK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYGFYDECKR 10 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;H0Y3Y6;P62140;E7ETD8;P62136;P62136-2;P62136-3 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 106691000.0 8476500.0 26729000.0 71485500.0 True False 10972996.346794935 25241507.653320637 58475872.50317091 1.0 2.3003295413192535 5.329070625294697 23.387454194000256 -6.956959518810593 0.47635379652717563 0.9247476991825828 6.830153506049343 0.9996402851870487 0.03439856302581189 0.08080564801456619 0.025284111144605718 0.042393620113570334 0.2498835525485731 1.104181537393945e-07 6.956959518810593 5.90540580686676 IYGISFPDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYGISFPDPK 10 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 3694500.0 1280800.0 2413700.0 0.0 False True 1679141.203284842 2053585.3685289093 0.0 1.0 1.2229974254169667 0.0 20.679292124621853 -6.907395296168169 1.2836679484858182 1.1164480431097743 7.19789126345302e-20 0.9518104717025468 0.1167447649226419 0.12977146769036996 0.4287783891047199 0.07446773452115996 0.14728024522227615 1.2376695430784694e-07 6.907395296168169 -1.1164480431097743 down IYGISFPDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYGISFPDPK 10 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 5030470.0 1374600.0 687470.0 2968400.0 False True 1330964.0754179973 961980.3561086893 2190886.989908828 1.0 0.7227695877565843 1.6460902517002698 20.34404020074246 -6.826200469718762 1.3447124936347903 0.851429808481903 1.6690766704005588 0.8980701074948391 0.12350449172423944 0.18555219496920108 0.6575063982389264 0.07213736611175713 0.1660658331438137 1.492105496803134e-07 6.826200469718762 0.8176468619186559 IYGISFPDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYGISFPDPK 10 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 3668200.0 1280800.0 2387400.0 0.0 False True 1754346.3723185475 2281916.773923949 0.0 1.0 1.300721915540637 0.0 20.742502186144744 -6.8828007249767635 1.3340456486900132 1.156899663765138 5.856263691539631e-19 0.9329036409196667 0.14402274094874198 0.1467232615083473 0.5248291678826787 0.0876648922184476 0.17807468293665307 1.3097827759503757e-07 6.8828007249767635 -1.156899663765138 down IYGLGSLALYEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYGLGSLALYEK 12 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 40772000.0 12747000.0 16241000.0 11784000.0 False True 16711440.442123583 13817906.10692217 10564704.720109787 1.0 0.826853086349885 0.6321839674262868 23.9943327560274 -6.969605812420904 0.26743235839244356 1.0499246767465387 0.40328002202058394 0.9999791418789284 0.00068615926708456 0.07643081299286258 0.009486825698661175 0.0038768494150969684 0.018170098712804592 1.0724923117182734e-07 6.969605812420904 -0.6466446547259548 IYGLGSLALYEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYGLGSLALYEK 12 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 48987600.0 20021000.0 8339600.0 20627000.0 False True 19385444.31394132 11669645.770439476 15224169.903264191 1.0 0.6019797937799695 0.7853402613173799 24.208470466216994 -10.063258555637297 4.76080497908046 1.0000096604896196 0.6936600275434166 0.7882092951297655 0.07485659743170715 103834217.62421477 0.27747057266218683 12100.274521582844 0.025625404366477332 8.644531165350877e-11 10.063258555637297 -0.306349632946203 IYGLGSLALYEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYGLGSLALYEK 12 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 55916000.0 10103000.0 27725000.0 18088000.0 False True 15326989.628235316 22777257.133586284 14512898.871747956 1.0 1.4860881155439758 0.9468851499065645 23.869571029512404 -6.669227761985242 1.9402487992679398 1.3104789161428478 0.9490795089338555 0.27554899220070384 0.20651743658526095 0.46290694463302856 3.3589533391320776 0.0857143760697442 0.22922661718917287 2.1417670753135319e-07 6.669227761985242 -0.36139940720899233 IYGLGSLALYEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYGLGSLALYEK 12 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 52134000.0 12747000.0 16418000.0 22969000.0 False True 17459910.374722462 15692598.472934313 17544195.261403915 1.0 0.8987788674822311 1.0048273378770303 24.057542817550292 -11.0673226774464 8.964662410676643 1.1934390529516063 0.9518031026796305 0.21593386977670959 0.04329410674498434 0.05125755901585477 0.0003849335985155012 0.012837030505339608 0.013973112867687551 8.56401309229422e-12 11.0673226774464 -0.24163595027197582 IYGLGSLALYEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYGLGSLALYEK 12 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 40218000.0 20021000.0 9746000.0 10451000.0 False True 16648348.580685891 9693496.363570469 12636255.780035693 1.0 0.5822497238444481 0.7590095629482005 23.98887574165127 -10.198284494187815 5.4123893583417075 1.000015083010658 0.670629643396276 0.8223665071116717 0.07216190213694454 1.3134264734464304e-05 1.945559240380493e-06 0.06987365834208921 0.023290153767228334 6.3345461688253e-11 10.198284494187815 -0.32938543961438205 IYGLGSLALYEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYGLGSLALYEK 12 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 63810000.0 10103000.0 30326000.0 23381000.0 False True 13078532.659903169 28638331.441303533 19125897.909319185 1.0 2.189720527984335 1.4623886644375892 23.640697351604853 -10.171968539204988 4.730256173211324 0.9999595424275436 1.8260545961887695 0.6323328969521825 0.2969319919034815 0.00031330825794416157 5.484349765594241e-05 0.28753762944099176 0.09583438799719136 6.730254092581821e-11 10.171968539204988 0.8260950537612259 IYGNK(ub)TELLVDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYGNKTELLVDR 12 1 A0A5K1VW28;H0YH69;Q9HBU6;Q86U68;A0A5F9ZI33;Q9HBU6-2 A0A5K1VW28 ETNK1 Ethanolamine kinase 1 1 103668600.0 29545600.0 36039000.0 38084000.0 True False 38734567.71999738 30662121.6789217 34143433.00752383 1.0 0.7915958143787895 0.8814719000954978 25.207118303414745 -10.130227912277421 4.540956157965394 1.0000169929777547 0.836533857234152 0.8151805222434896 0.03669175837005654 51234148.63614734 0.8864303120592089 9834.443939463614 0.012560564830165068 7.409213130787688e-11 10.130227912277421 -0.16348313574360274 IYGNK(ub)TELLVDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYGNKTELLVDR 12 1 A0A5K1VW28;H0YH69;Q9HBU6;Q86U68;A0A5F9ZI33;Q9HBU6-2 A0A5K1VW28 ETNK1 Ethanolamine kinase 1 1 79470700.0 23582000.0 21448700.0 34440000.0 True False 22833402.318134185 30013277.76349289 25419130.822146617 1.0 1.314446149781913 1.1132432419832088 24.444642510273606 -10.216342436153202 3.81150861773938 0.9997823625124007 1.2138446958423754 0.6009810122233673 0.0821407434722442 58292887.66549184 107610190.65681653 154909.99734667683 0.030060431625907498 6.076556828890502e-11 10.216342436153202 0.2140623333299747 IYGNK(ub)TELLVDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYGNKTELLVDR 12 1 A0A5K1VW28;H0YH69;Q9HBU6;Q86U68;A0A5F9ZI33;Q9HBU6-2 A0A5K1VW28 ETNK1 Ethanolamine kinase 1 1 85242600.0 29545600.0 24710000.0 30987000.0 True False 40469406.759818 23618230.49495716 23668508.797297396 1.0 0.5836070351890519 0.584849413231276 25.270328364937637 -10.327198165317354 5.712095777604818 1.000059668286778 0.5842282243978126 0.9999933025088209 0.000507198711856586 3.854642784496278e-07 4.540165555187596e-08 0.000491163219095505 0.00016369768035193666 4.7076247199452405e-11 10.327198165317354 -0.4158314438889653 IYGNK(ub)TELLVDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYGNKTELLVDR 12 1 A0A5K1VW28;H0YH69;Q9HBU6;Q86U68;A0A5F9ZI33;Q9HBU6-2 A0A5K1VW28 ETNK1 Ethanolamine kinase 1 1 77964000.0 23582000.0 35293000.0 19089000.0 True False 19609477.859734032 35102869.60388798 23080421.642436236 1.0 1.7900971078872006 1.1770033759965337 24.225047785707883 -10.073368718349258 4.436970800392944 0.9999667030056564 1.4835502410998662 0.4533750655504819 0.2502944680744612 86883592.54092816 2.612536451724427 33207.94661453925 0.08568245384413684 8.445615034343648e-11 10.073368718349258 0.48358353809420984 IYGNK(ub)TELLVDRDEEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYGNKTELLVDRDEEVK 17 2 A0A5K1VW28;H0YH69;Q9HBU6;Q86U68;A0A5F9ZI33;Q9HBU6-2 A0A5K1VW28 ETNK1 Ethanolamine kinase 1 1 136860000.0 34928000.0 55742000.0 46190000.0 True False 45790946.24323311 47425510.8806142 41410701.88576634 1.0 1.0356962406650998 0.9043425673232497 25.44855904198375 -6.834300073264868 1.308423681727624 1.019025656925926 0.9004831660351501 0.9142229067809803 0.01624181310396839 0.17557160005554923 0.5862795920738221 0.009741222643750729 0.022421209534231025 1.4645355788851456e-07 6.834300073264868 -0.11854249089077584 IYGNK(ub)TELLVDRDEEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYGNKTELLVDRDEEVK 17 2 A0A5K1VW28;H0YH69;Q9HBU6;Q86U68;A0A5F9ZI33;Q9HBU6-2 A0A5K1VW28 ETNK1 Ethanolamine kinase 1 1 213383000.0 59172000.0 79797000.0 74414000.0 True False 57293617.249115236 111660358.23585774 54922741.0278519 1.0 1.9489144445244826 0.9586188421136921 25.771871089826266 -6.655849082314117 1.9875173187705022 1.6128744847030356 0.9627607837453769 0.21816519910466636 0.4044292307977037 0.4943542643782057 3.7494311177325175 0.16464824011026213 0.44818149720040756 2.2087721497917145e-07 6.655849082314117 -0.6501137009576587 IYGNK(ub)TELLVDRDEEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYGNKTELLVDRDEEVK 17 2 A0A5K1VW28;H0YH69;Q9HBU6;Q86U68;A0A5F9ZI33;Q9HBU6-2 A0A5K1VW28 ETNK1 Ethanolamine kinase 1 1 355700000.0 103340000.0 141650000.0 110710000.0 True False 156774335.1659742 116371450.78349869 88828119.97408324 1.0 0.7422863612229534 0.5665986073552313 27.224114160648107 -7.978787552573834 0.10483221451212943 1.4821467670770874 2.2772846082901588e-10 0.9999886452078137 0.0005997379153193607 0.11107249748333685 0.01688843030116872 0.1050938370513478 0.12146348745334584 1.0500559676045289e-08 7.978787552573834 -1.4821467668493589 IYGNK(ub)TELLVDRDEEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYGNKTELLVDRDEEVK 17 2 A0A5K1VW28;H0YH69;Q9HBU6;Q86U68;A0A5F9ZI33;Q9HBU6-2 A0A5K1VW28 ETNK1 Ethanolamine kinase 1 1 136519000.0 34928000.0 52137000.0 49454000.0 True False 47841825.493708804 49833414.94599684 37773983.73710086 1.0 1.0416286258255327 0.7895598327883232 25.51176910350664 -6.864498731231986 1.1628828122993007 1.0229150838310679 0.7762670412305593 0.95887294870567 0.022374943895861036 0.1422341517186465 0.36298155211898997 0.014977828832259009 0.035157340712131044 1.3661590668449515e-07 6.864498731231986 -0.24664804260050854 IYGNK(ub)TELLVDRDEEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYGNKTELLVDRDEEVK 17 2 A0A5K1VW28;H0YH69;Q9HBU6;Q86U68;A0A5F9ZI33;Q9HBU6-2 A0A5K1VW28 ETNK1 Ethanolamine kinase 1 1 178016000.0 59172000.0 75765000.0 43079000.0 True False 49204139.764065035 75356838.90682492 52086619.72520886 1.0 1.5315142032390499 1.0585820618949013 25.552276365260543 -10.415890511660162 3.8288353867001357 0.9982910963208546 1.2950481325671903 0.3416511547197131 0.19307373828407157 16496958.891196378 44884324.24323013 145620.44865912816 0.06609417167030512 3.838039926699769e-11 10.415890511660162 0.29675703624633576 IYGNK(ub)TELLVDRDEEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYGNKTELLVDRDEEVK 17 2 A0A5K1VW28;H0YH69;Q9HBU6;Q86U68;A0A5F9ZI33;Q9HBU6-2 A0A5K1VW28 ETNK1 Ethanolamine kinase 1 1 420932000.0 103340000.0 219430000.0 98162000.0 True False 133775667.13593917 207218527.60552758 80297523.22717552 1.0 1.5490001436132461 0.6002401254749817 26.995240482740556 -6.749836444044867 1.6507258754494305 1.3228827558459522 0.5984087860885045 0.6481737403316397 0.23068986574321246 0.30032102550787015 1.610089770922274 0.11040606066269582 0.26805311510632274 1.7789492388609144e-07 6.749836444044867 -0.7244739697574477 IYHCNINSQGVICLDILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYHCNINSQGVICLDILK 18 0 C9J2P0;P51965;H7C061;B7Z306;P51965-2;P51965-3;A0A087X283;R4GND1;A0A1B0GX65;Q96LR5;Q969T4 C9J2P0;R4GND1 UBE2E1;UBE2E2;UBE2E3 Ubiquitin-conjugating enzyme E2 E1;Ubiquitin-conjugating enzyme E2 E2;Ubiquitin-conjugating enzyme E2 E3 0 29691400.0 12040000.0 6130400.0 11521000.0 False True 15586017.343881441 5789237.850945296 9424296.21544272 1.0 0.3714379192076262 0.6046635267695496 23.893748991075398 -10.211688647561031 5.453096170764312 1.0000257329346243 0.4880507229885632 0.8653110109346744 0.09521395557973285 2.978903961786897e-05 4.306506494378014e-06 0.09219514001635964 0.030730172023876828 6.142021784148353e-11 10.211688647561031 -0.511975009946061 IYHCNINSQGVICLDILK(ub)DNWSPALTISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYHCNINSQGVICLDILKDNWSPALTISK 29 1 C9J2P0;P51965;H7C061;B7Z306;P51965-2;P51965-3;A0A087X283;R4GND1;A0A1B0GX65;Q96LR5;Q969T4 C9J2P0;R4GND1 UBE2E1;UBE2E2;UBE2E3 Ubiquitin-conjugating enzyme E2 E1;Ubiquitin-conjugating enzyme E2 E2;Ubiquitin-conjugating enzyme E2 E3 1 202509000.0 66298000.0 71672000.0 64539000.0 True False 100578913.03303427 58881571.62410803 51782838.36155147 1.0 0.5854266053240096 0.514847862240705 26.583752626354375 -13.999999999999998 0.24909730625973117 3.870100015540036 0.4862245853871058 0.9995410003693249 0.0045851311417685866 13.962428533457032 0.15793338946409224 20.040941204838056 0.03273610268282608 1.0000000000000041e-14 13.999999999999998 -3.38387543015293 IYHCNINSQGVICLDILK(ub)DNWSPALTISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYHCNINSQGVICLDILKDNWSPALTISK 29 1 C9J2P0;P51965;H7C061;B7Z306;P51965-2;P51965-3;A0A087X283;R4GND1;A0A1B0GX65;Q96LR5;Q969T4 C9J2P0;R4GND1 UBE2E1;UBE2E2;UBE2E3 Ubiquitin-conjugating enzyme E2 E1;Ubiquitin-conjugating enzyme E2 E2;Ubiquitin-conjugating enzyme E2 E3 1 131309000.0 66298000.0 28356000.0 36655000.0 True False 85824067.92895778 26777963.673072718 29984166.112060845 1.0 0.31200995617265076 0.3493678036431542 26.354878948446824 -10.121233499883262 5.540412298729035 1.000009055220331 0.33068887990776547 0.9976689296470489 0.015251277365725884 1.7059063392474732e-06 2.705554399798166e-07 0.01476718541134546 0.004922328603750418 7.564260906489285e-11 10.121233499883262 -0.6693201753125655 IYHPNINSNGSICLDILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYHPNINSNGSICLDILR 18 0 P61077;P61077-3;P61077-2;D6RAH7;H9KV45;A0A0A0MQU3;A0A087WY85;P62837-2;P62837;P51668;D6RAW0;Q9Y2X8;A0A087WW00;D6RFM0;D6RA11;C9J9H9 P61077 UBE2D3;UBE2D2;UBE2D1;UBE2D4 Ubiquitin-conjugating enzyme E2 D3;Ubiquitin-conjugating enzyme E2 D2;Ubiquitin-conjugating enzyme E2 D1;Ubiquitin-conjugating enzyme E2 D4 0 38820300.0 26556000.0 8257400.0 4006900.0 False True 25712994.31601949 11554622.881772151 2957372.6855766373 1.0 0.44936901318309275 0.11501471393139771 24.61599428812616 -8.436835841904973 0.34977258650085696 1.1256233040368138 1.6829688151671265e-18 0.99799906808136 0.016321386065688694 0.1544909216565612 0.0977771119303212 0.09895871582253336 0.08766694882689774 3.657330081712741e-09 8.436835841904973 -1.1256233040368138 IYHPNINSNGSICLDILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYHPNINSNGSICLDILR 18 0 P61077;P61077-3;P61077-2;D6RAH7;H9KV45;A0A0A0MQU3;A0A087WY85;P62837-2;P62837;P51668;D6RAW0;Q9Y2X8;A0A087WW00;D6RFM0;D6RA11;C9J9H9 P61077 UBE2D3;UBE2D2;UBE2D1;UBE2D4 Ubiquitin-conjugating enzyme E2 D3;Ubiquitin-conjugating enzyme E2 D2;Ubiquitin-conjugating enzyme E2 D1;Ubiquitin-conjugating enzyme E2 D4 0 460920000.0 127410000.0 170080000.0 163430000.0 False True 193290284.91868362 139727895.15889472 131127988.86608629 1.0 0.7228914542584364 0.6783992735136753 27.526193886291804 -13.999999999393806 0.25742795016413544 3.001655969822401 0.6617325509010618 0.9995571294711546 0.0029942318314635746 14.304886627956675 0.1605508807072044 14.872446758021049 0.01971843994947751 1.0000000013958138e-14 13.999999999393806 -2.339923418921339 IYHPNINSNGSICLDILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYHPNINSNGSICLDILR 18 0 P61077;P61077-3;P61077-2;D6RAH7;H9KV45;A0A0A0MQU3;A0A087WY85;P62837-2;P62837;P51668;D6RAW0;Q9Y2X8;A0A087WW00;D6RFM0;D6RA11;C9J9H9 P61077 UBE2D3;UBE2D2;UBE2D1;UBE2D4 Ubiquitin-conjugating enzyme E2 D3;Ubiquitin-conjugating enzyme E2 D2;Ubiquitin-conjugating enzyme E2 D1;Ubiquitin-conjugating enzyme E2 D4 0 308464000.0 127410000.0 94323000.0 86731000.0 False True 164934756.6265725 89073842.13341928 70946847.93521081 1.0 0.5400550129957792 0.43015098446375993 27.297320208384253 -13.999999999999876 0.20108435235585043 3.5673819384990653 0.35953206814318683 0.9994870080093421 0.005590687019462015 12.552563706806868 0.14218366507019484 12.68099148103174 0.06941961076666568 1.0000000000002864e-14 13.999999999999876 -3.2078498703558784 IYHPNVDK(ub)LGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYHPNVDKLGR 11 1 P61088;F8VSD4;F8VV71;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 1 60973400.0 26674000.0 26992000.0 7307400.0 True False 34969872.311383426 22964898.813991945 6551300.345530401 1.0 0.6567052521526191 0.18734127157215313 25.05960919241559 -7.392130239180855 0.43259741735401674 1.0254710983563613 4.6432030062765596e-18 0.998914162730826 0.010976146323017622 0.11083489125344739 0.04492995923331683 0.015505928300150172 0.06025721619222675 4.053869470250836e-08 7.392130239180855 -1.0254710983563613 down IYHPNVDK(ub)LGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYHPNVDKLGR 11 1 P61088;F8VSD4;F8VV71;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 1 95594000.0 38383000.0 39162000.0 18049000.0 True False 37164552.67479193 54799590.827132136 13321425.441606412 1.0 1.4745123210995015 0.358444390765992 25.147423907563688 -6.791175978518109 1.4915523573390095 1.2647981546345504 0.34617300619600366 0.8051423210619022 0.20187810335877515 0.2335986476822075 1.0266305394729094 0.10652568043491788 0.24919924525060924 1.61742451551173e-07 6.791175978518109 -0.9186251484385467 down IYHPNVDK(ub)LGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYHPNVDKLGR 11 1 P61088;F8VSD4;F8VV71;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 1 102510000.0 47732000.0 20786000.0 33992000.0 True False 72412933.67662352 17076575.898240726 27273466.300777152 1.0 0.23582218025442903 0.37663805229288233 26.109744064346707 -9.882097019408485 6.552153941711895 1.000000032850565 0.3062301163580762 0.9700278563676638 0.05748783903000859 2.7613951565783266e-08 4.620516713942737e-09 0.05566236328139798 0.018554120264370193 1.3119067922811e-10 9.882097019408485 -0.6937699164924888 IYHPNVDK(ub)LGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYHPNVDKLGR 11 1 P61088;F8VSD4;F8VV71;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 1 60356000.0 26674000.0 22488000.0 11194000.0 True False 36536098.63774591 21494405.802128587 8550207.747666676 1.0 0.5883059933476981 0.23402081958562884 25.12281925393848 -7.7671978861940385 0.30685591142341906 1.1007939196678032 9.812080977293784e-14 0.9993765547395629 0.007815316948611113 0.12054921153685574 0.046999204057293444 0.03875160208126483 0.08088148119640125 1.7092363244400556e-08 7.7671978861940385 -1.100793919667705 down IYHPNVDK(ub)LGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYHPNVDKLGR 11 1 P61088;F8VSD4;F8VV71;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 1 109204000.0 38383000.0 59972000.0 10849000.0 True False 31917165.155210342 59648918.932490036 13117475.739891618 1.0 1.8688664435711202 0.4109849880496121 24.927829182997964 -6.745273960784905 1.6674864560016984 1.5137820825258768 0.4091163583105912 0.6283762239978445 0.365047360614584 0.30833437616541676 1.6852584262709238 0.17305803328431751 0.42221920157359416 1.7977365127793124e-07 6.745273960784905 -1.1046657242152855 IYHPNVDK(ub)LGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYHPNVDKLGR 11 1 P61088;F8VSD4;F8VV71;F8VQQ8 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 1 102304000.0 47732000.0 31259000.0 23313000.0 True False 61790014.93838439 29519409.171130635 19070273.211580276 1.0 0.4777375309031196 0.3086303382609103 25.880870386439156 -13.999999999999998 0.1577106705604359 3.560017872212995 0.13811775369152332 0.9995425782531692 0.0062936486596305375 11.995205453913073 0.1254170057076175 9.395547492311625 0.1549726705734423 1.0000000000000041e-14 13.999999999999998 -3.4219001185214717 IYHTIAYLTPLPQPNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYHTIAYLTPLPQPNR 16 0 P10620;F5H760 P10620 MGST1 Microsomal glutathione S-transferase 1 0 53887000.0 19346000.0 21697000.0 12844000.0 False True 25362793.34693052 18459892.17424357 11515026.088347752 1.0 0.7278335600395388 0.45401253445694834 24.596210310549882 -6.9710502069898945 0.23173906061255692 1.108967231521871 0.06503862528218288 0.9999894535050926 0.0007238489883147949 0.07596341954596694 0.0078002755783561015 0.006946429790449018 0.027104875266504232 1.0689312973505467e-07 6.9710502069898945 -1.0439286062396882 down IYHTIAYLTPLPQPNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYHTIAYLTPLPQPNR 16 0 P10620;F5H760 P10620 MGST1 Microsomal glutathione S-transferase 1 0 32933700.0 13589000.0 4258700.0 15086000.0 False True 13157624.633242521 5959221.118827111 11134524.029701058 1.0 0.45291010231217854 0.8462411977895969 23.649395724777303 -9.865400817645323 5.780799713094365 1.000000096761736 0.6495756500502317 0.5141632823720423 0.16057674731728966 2.003193724236533e-07 3.927595992435021e-08 0.15547781105490152 0.05182592234532475 1.3633243209560496e-10 9.865400817645323 -0.3504244467115043 IYHTIAYLTPLPQPNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYHTIAYLTPLPQPNR 16 0 P10620;F5H760 P10620 MGST1 Microsomal glutathione S-transferase 1 0 22908200.0 13589000.0 4909900.0 4409300.0 False True 11299855.594772516 4883449.39416116 5331264.243700253 1.0 0.43216918598679416 0.471799325131781 23.42980100021158 -10.003033497187383 6.113449258761489 1.0000004404421945 0.4519842575768984 0.9960931530682318 0.016178936556913125 9.712404481953976e-08 1.5845946763963908e-08 0.015665200332161504 0.00522172932033729 9.93039452210625e-11 10.003033497187383 -0.5480161828652961 IYISNTFSPSK(ub)AEGDSAGTAGTPGGTPAGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYISNTFSPSKAEGDSAGTAGTPGGTPAGDK 31 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 8489300.0 1300600.0 3167800.0 4020900.0 True False 1259313.1649124469 4432719.059858764 2967705.6655856357 1.0 3.519949749883657 2.3566065600465347 20.264205665156886 -9.246327376410282 17.593571282106623 1.0000409872486435 2.938278154965097 0.7872932414277146 0.47493286906332344 0.0 0.0 0.45985177284580697 0.15328392428193563 5.671169446587168e-10 9.246327376410282 1.9382371677164536 IYITLTGVHQVPTENVQVHFTER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYITLTGVHQVPTENVQVHFTER 23 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 160554800.0 93922000.0 18357300.0 48275500.0 False True 90940497.52030346 25687465.622054864 35630698.316043526 1.0 0.28246453804939714 0.3918023244604373 26.43841956105967 -10.296793795195393 7.258782436490883 1.0000052120081235 0.33713343127059436 0.9800024516835538 0.04463696438541013 3.7650056235744727e-06 3.647463238378564e-07 0.04321989431384538 0.014406518307495578 5.049009697155201e-11 10.296793795195393 -0.6628717807375292 IYITLTGVHQVPTENVQVHFTER ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYITLTGVHQVPTENVQVHFTER 23 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 2942570000.0 944120000.0 1087530000.0 910920000.0 False True 1432299064.4174538 893451774.589326 730876262.7295804 1.0 0.6237885625881573 0.5102818823852567 30.41568561314184 -13.999999999999998 0.16789786728527825 2.8870317050048264 0.4078819836845319 0.9995178474241354 0.004595708237280777 12.071765337044138 0.12971175728245243 7.417953336425322 0.09434222995043384 1.0000000000000041e-14 13.999999999999998 -2.4791497213202947 IYITLTGVHQVPTENVQVHFTER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYITLTGVHQVPTENVQVHFTER 23 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 231191900.0 93922000.0 60151900.0 77118000.0 False True 78100304.45008639 59827849.77548263 93243017.24665518 1.0 0.7660386242632177 1.193888012386001 26.218824836493948 -6.758241792548611 1.6192616761733623 0.8638042489205312 1.1953073360532087 0.6836821119282415 0.09838099784765773 0.2858811896360771 1.4769759246569185 0.04794862113528666 0.11542108279120333 1.744850440596125e-07 6.758241792548611 0.3315030871326775 IYITLTGVHQVPTENVQVHFTER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYITLTGVHQVPTENVQVHFTER 23 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 2425190000.0 944120000.0 824730000.0 656340000.0 False True 1222181951.3874876 778833050.5040653 536892854.6171057 1.0 0.6372480379209425 0.43929044608095846 30.18681193523429 -10.78633390572837 0.11098839721627472 1.9463875962889159 1.7823702405600492e-16 0.99986267584353 0.002720813869600006 2.8810110656655623 0.0634537364009117 0.9874745738672809 0.2772510494840739 1.635558544672807e-11 10.78633390572837 -1.9463875962889157 IYIVMNYVEHDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYIVMNYVEHDLK 13 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 14287100.0 5475800.0 3685400.0 5125900.0 False True 5301973.726301383 5156999.439107104 3783273.0162962107 1.0 0.9726565436423971 0.7135593670577076 22.338098090334963 -6.927089902551246 0.7703035586416246 1.0043943784308478 0.6641062969680316 0.9959347470739647 0.008229296471254446 0.09417732640071523 0.08529077506178512 0.007371356862268898 0.02382997757396039 1.1827966816806155e-07 6.927089902551246 -0.3402880814628162 IYIVMNYVEHDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYIVMNYVEHDLK 13 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 62649800.0 18060200.0 16872000.0 27717600.0 False True 27398643.77747755 13861059.77846231 22239204.210944336 1.0 0.5059031348791244 0.8116899650786942 24.70760114630491 -10.40623729419457 6.1317496093320685 1.000078020579991 0.6587965499789111 0.624070911887662 0.12483695067533813 0.00013317961223211782 1.2896113888564313e-05 0.12090034915334316 0.04029095257974174 3.9243045670372195e-11 10.40623729419457 -0.34128147060107994 IYIVMNYVEHDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYIVMNYVEHDLK 13 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 3320700.0 1445200.0 1875500.0 0.0 False True 1979529.4950615007 1792634.208550879 0.0 1.0 0.9055860056761543 0.0 20.916726133060934 -7.1105531848588255 0.9785336184132355 0.9990397315466228 1.604382626089423e-18 0.9895741012431134 0.04603014555254326 0.08514202408771455 0.15483734478980565 0.038088218455005624 0.06718428636004319 7.752589972646397e-08 7.1105531848588255 -0.9990397315466228 down IYIVMNYVEHDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYIVMNYVEHDLK 13 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 13479250.0 5475800.0 4425450.0 3578000.0 False True 4553370.319070972 4401609.222466953 4326143.257197179 1.0 0.9666706009022823 0.9500969510601646 22.11850336576924 -13.999999999515179 0.09095785573502978 1.1699652279758088 0.9092704248076043 0.9998378244729287 0.0002642111748369681 12.155046255889905 0.08786064146156232 0.3981740029372949 0.03665001041045793 1.0000000011163418e-14 13.999999999515179 -0.2606948031682045 IYIVMNYVEHDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYIVMNYVEHDLK 13 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 40826400.0 18060200.0 22766200.0 0.0 False True 23379284.919764765 21499240.95690181 0.0 1.0 0.9195850527800544 0.0 24.47872746839736 -7.095553554772924 0.9952945119315115 1.0015711341228057 9.79381303507825e-18 0.9893760452621524 0.04675784024661274 0.08457745383022587 0.15952544495713092 0.03844871032609967 0.06800163561542814 8.02502594627325e-08 7.095553554772924 -1.0015711341228057 down IYIYPDK(ub)LGYETTDALPESSTCSSTLFLPHYASAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYIYPDKLGYETTDALPESSTCSSTLFLPHYASAK 35 1 Q5T447;Q5T447-2 Q5T447 HECTD3 E3 ubiquitin-protein ligase HECTD3 1 89692000.0 10738000.0 15993000.0 62961000.0 True False 13900552.677624483 15102975.491023123 51502744.0344145 1.0 1.0865017989776884 3.7050860659172002 23.72863890898887 -6.913925891873503 0.8685752056203071 0.9286376010118649 4.073524845565435 0.9923204819684247 0.1100053495032365 0.10187923481990195 0.12511021874764663 0.09184855917353246 0.26099979479932056 1.2191976253842545e-07 6.913925891873503 3.1448872445535705 up IYIYTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYIYTLK 7 0 H0YEW1;Q38SD2 H0YEW1 LRRK1 Leucine-rich repeat serine/threonine-protein kinase 1 0 114180000.0 30408000.0 40466000.0 43306000.0 False True 39865182.471490875 34428630.53523258 38825110.540484905 1.0 0.8636265633514614 0.9739102678948036 25.248625936854925 -10.059701653774043 4.526943929298223 1.000004270697615 0.9187684156193593 0.4197445762739087 0.04502313386175531 126881887048.40343 26358658310.986923 6205965.626181286 0.015412912690517857 8.715621192607288e-11 10.059701653774043 -0.08123585507825581 IYIYTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYIYTLK 7 0 H0YEW1;Q38SD2 H0YEW1 LRRK1 Leucine-rich repeat serine/threonine-protein kinase 1 0 110594000.0 30068000.0 40969000.0 39557000.0 False True 45615354.26524596 33657761.85774195 31738541.61155099 1.0 0.7378603630266132 0.6957863667351232 25.44301618583344 -13.999999999110006 0.25747800828273565 2.8940202915489146 0.6800330317729446 0.9995572296417043 0.0028320787959300233 14.307084558272662 0.1605670803975258 14.078027836152316 0.01864180178005901 1.0000000020492866e-14 13.999999999110006 -2.21398725977597 IYIYTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYIYTLK 7 0 H0YEW1;Q38SD2 H0YEW1 LRRK1 Leucine-rich repeat serine/threonine-protein kinase 1 0 125618000.0 30408000.0 30574000.0 64636000.0 False True 41650659.34530171 29223139.585302312 49370308.02020569 1.0 0.7016248972922622 1.185342772389383 25.311835998377816 -6.7398572529049625 1.6874356860642152 0.8224349021684416 1.1856047725344154 0.6041922164230689 0.12536476090622342 0.31808309552525343 1.7783781108623806 0.05877710326414017 0.1442442538081396 1.8202990695390344e-07 6.7398572529049625 0.3631698703659738 IYIYTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYIYTLK 7 0 H0YEW1;Q38SD2 H0YEW1 LRRK1 Leucine-rich repeat serine/threonine-protein kinase 1 0 139260000.0 30068000.0 68254000.0 40938000.0 False True 38923618.72888933 64455604.89991194 33487704.059352007 1.0 1.655950988238219 0.860344057231689 25.21414250792589 -6.687674122771854 1.8744574229650626 1.4121240870807692 0.8631503943595166 0.35968008246534633 0.2775521077146098 0.4216767071892661 2.8706510080710212 0.11852951045583875 0.30959247997855965 2.052701866563697e-07 6.687674122771854 -0.5489736927212526 IYK(ub)IGQGYLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYKIGQGYLIK 11 1 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 1 64356000.0 16779900.0 26173500.0 21402600.0 True False 21998611.396782763 22268515.823503904 19188064.260236055 1.0 1.0122691574414835 0.8722397934190635 24.39090912458868 -6.885551236643059 1.0483182380158427 1.00834573520811 0.86119454040324 0.9778955809582581 0.009413693650221764 0.1228279289524027 0.2435158671245831 0.006878859571108111 0.01689659234772417 1.3015137581834208e-07 6.885551236643059 -0.14715119480487004 IYK(ub)IGQGYLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYKIGQGYLIK 11 1 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 1 120494400.0 36289000.0 40875500.0 43329900.0 True False 35137025.55859435 57197300.31291653 31980499.320863288 1.0 1.627835578100786 0.9101652405816976 25.06648873280622 -6.675523691539986 1.9179982371082818 1.39879671703236 0.9129858225974395 0.30395512775669764 0.26635000457780705 0.44837174004365155 3.1850406679269483 0.11159788779459333 0.29600830520552623 2.110942037007558e-07 6.675523691539986 -0.48581089443492054 IYK(ub)IGQGYLIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYKIGQGYLIK 11 1 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 1 110724000.0 40146000.0 24173000.0 46405000.0 True False 60904417.06573633 19859139.285488956 37233031.409965955 1.0 0.3260705913013546 0.6113354860580802 25.86004352695311 -10.428259472873343 6.057699935930106 1.000182769943459 0.46870303867992785 0.8222239060530185 0.11645890561378745 0.0002875634555206841 2.7140979537359713e-05 0.11279890179111063 0.03758695016331163 3.730272229685394e-11 10.428259472873343 -0.5314797312635311 IYK(ub)IGQGYLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYKIGQGYLIK 11 1 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 1 71735700.0 16779900.0 27625500.0 27330300.0 True False 22983882.489747066 26404914.064687926 20875446.0251969 1.0 1.1488448079416937 0.9082645647230957 24.454119186111573 -6.7393401329975715 1.6889888088396174 1.0886291656397942 0.9081403246402958 0.6020244212844426 0.06253936527898535 0.3190138727738889 1.7866043665339542 0.029294862699093288 0.0719425278641825 1.8224678134779088e-07 6.7393401329975715 -0.18048884099949836 IYK(ub)IGQGYLIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYKIGQGYLIK 11 1 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 1 126532100.0 36289000.0 68962000.0 21281100.0 True False 30175911.375281513 68590488.0181148 25730879.61731103 1.0 2.2730212574225828 0.8526960229074767 24.846894008240497 -6.670484507558721 1.9360243366490288 1.8122501265000308 0.8584738343875005 0.28102412815653366 0.5406958429096578 0.46001340809871033 3.324706112488768 0.22481953178297054 0.6002015177440784 2.1355782664553275e-07 6.670484507558721 -0.9537762921125303 IYK(ub)IGQGYLIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYKIGQGYLIK 11 1 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 1 94977600.0 40146000.0 25624500.0 29207100.0 True False 51969788.39596871 24198474.04925417 23891707.49015342 1.0 0.46562579521934794 0.4597230088396261 25.63116984904556 IYK(ub)LDDPSCPRPECYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYKLDDPSCPRPECYR 16 2 P41091;H7BZU1 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 28790100.0 5161900.0 9488200.0 14140000.0 True False 6767300.887910702 8072597.54471392 12676928.440457594 1.0 1.192882905374436 1.8732621248013395 22.690149104442696 -6.947764955566543 0.582863969779027 0.9919513907544543 2.1080123136646334 0.9990140204878507 0.01176153039964866 0.08439581462862081 0.039773631791619114 0.012285160420498736 0.05688102675216335 1.1278076716074945e-07 6.947764955566543 1.116060922910179 IYK(ub)LDDPSCPRPECYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYKLDDPSCPRPECYR 16 2 P41091;H7BZU1 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 85352400.0 27848400.0 18045000.0 39459000.0 True False 42248058.790750064 14824728.763771472 31659911.354505923 1.0 0.3508972764215441 0.7493814452236478 25.332381718333046 -10.768425144679366 6.841455352200993 1.0117157194307822 0.5501393608228072 0.6295349393940535 0.16268048069037225 0.02884516154670846 0.0009763720015923524 0.15629292160023778 0.05250489937223573 1.7044130679063406e-11 10.768425144679366 -0.46157635860797497 IYK(ub)LDDPSCPRPECYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYKLDDPSCPRPECYR 16 2 P41091;H7BZU1 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 23015800.0 5161900.0 8063600.0 9790300.0 True False 7070393.925102367 7707323.489240654 7478032.777557707 1.0 1.0900840279743063 1.0576543339414344 22.753359165965588 -10.016676153492972 4.7511998771197135 0.9999984278462671 1.0738691809601704 0.8737052171244512 0.013239367157088622 2.2047697390267688e-07 4.5673732169427815e-08 0.01281923509114381 0.004272987375023042 9.623296048242416e-11 10.016676153492972 0.07387075311390323 IYK(ub)LDDPSCPRPECYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYKLDDPSCPRPECYR 16 2 P41091;H7BZU1 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 82609500.0 27848400.0 22436000.0 32325100.0 True False 36050302.77403217 21187416.87717092 26442263.48353507 1.0 0.5877181395667136 0.7334824245243793 25.103508040425496 -10.226130726117908 6.415261787520054 1.0000036824554017 0.6606002820455462 0.8784739323292069 0.05950802014465512 3.1342766212820383e-06 3.7795577135871373e-07 0.057619017625326986 0.019206130915501957 5.941132988357984e-11 10.226130726117908 -0.3394034004098555 IYK(ub)LNEDMACSVAGITSDANVLTNELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYKLNEDMACSVAGITSDANVLTNELR 27 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;H0YKT8;H0YLC2;H0YLS6 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 1 40485900.0 7127900.0 17534000.0 15824000.0 True False 10813545.41929114 14404920.706232706 12696379.46409441 1.0 1.3321182043157305 1.1741181057458114 23.36633627888641 -10.535244799584884 5.774671169961211 0.999475778499237 1.2531181550307704 0.7738541968855563 0.06450327013429157 0.0004362173662075461 3.510749020334068e-05 0.06258132518036029 0.02081834091716908 2.91578300583034e-11 10.535244799584884 0.25364237653153343 IYK(ub)LNEDMACSVAGITSDANVLTNELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYKLNEDMACSVAGITSDANVLTNELR 27 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;H0YKT8;H0YLC2;H0YLS6 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 1 29903400.0 7127900.0 8712500.0 14063000.0 True False 9227207.061914649 8227641.716096971 11503678.29856533 1.0 0.8916719502325476 1.246712924222415 23.13746260097886 -6.824823445970284 1.350831480842149 0.941878730985943 1.2552984936407945 0.8951289250703626 0.04811248652782496 0.18728675197853217 0.6701557306569991 0.02797842876817157 0.06441951164138095 1.4968440454446432e-07 6.824823445970284 0.3134197626548515 IYK(ub)SELNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYKSELNK 8 1 Q8IWA4 Q8IWA4 MFN1 Mitofusin-1 1 2492320.0 553950.0 388970.0 1549400.0 True False 758760.2849358687 371784.0192482189 1183463.6308946507 1.0 0.4899887706690428 1.5597332311543934 19.53328464155526 -6.777086262489965 1.5474162154773525 0.7101184640301307 1.5674143546084247 0.7568525638853718 0.21542474518381483 0.2551432069250533 1.2065371443138286 0.10967652785131919 0.25940723659316045 1.6707587240195855e-07 6.777086262489965 0.857295890578294 IYK(ub)YIHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYKYIHK 7 1 Q15800;D6RDP9;D6R952;Q15800-2 Q15800 MSMO1 Methylsterol monooxygenase 1 1 6296200.0 1218900.0 1775300.0 3302000.0 True False 1597989.70384439 1510432.1600651983 2960340.7150205746 1.0 0.9452076921593745 1.8525405438462377 20.60782668205784 -6.892544122103288 1.0072294088841875 0.9541794762989686 1.9345778118665828 0.9824767218247391 0.05498995966814479 0.11710253423266452 0.20999302107968623 0.04145432563419529 0.10433738182949374 1.2807249728044526e-07 6.892544122103288 0.9803983355676142 IYK(ub)YIHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYKYIHK 7 1 Q15800;D6RDP9;D6R952;Q15800-2 Q15800 MSMO1 Methylsterol monooxygenase 1 1 11003100.0 877800.0 1623700.0 8501600.0 True False 849934.7194834277 2272051.87748364 6274775.9174669515 1.0 2.6732075127658566 7.382656307158069 19.696992511576273 -6.952875268171934 0.5263335762260882 0.9237148895995299 9.344602356167353 0.9994080288974113 0.0657456933179917 0.08235133627661508 0.03134019125921639 0.07375231910220002 0.3892696330583124 1.1146146112370846e-07 6.952875268171934 8.420887466567823 IYK(ub)YIHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYKYIHK 7 1 Q15800;D6RDP9;D6R952;Q15800-2 Q15800 MSMO1 Methylsterol monooxygenase 1 1 36360900.0 1492900.0 10793000.0 24075000.0 True False 2264838.4456094736 8866904.823906116 19316565.697552644 1.0 3.9150275116069087 8.528893411801171 21.11097671362191 -6.964349014961995 0.36905386124933165 0.6413627248283471 11.962921616685493 0.9998990915028942 0.03113678581126634 0.07818256355048858 0.015643073367426985 0.06090309485150547 0.39205292427244 1.0855528829000003e-07 6.964349014961995 11.321558891857146 IYK(ub)YIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYKYIHK 7 1 Q15800;D6RDP9;D6R952;Q15800-2 Q15800 MSMO1 Methylsterol monooxygenase 1 1 9400520.0 1218900.0 850920.0 7330700.0 True False 1669560.2695339464 813323.5407838519 5599339.640505635 1.0 0.48714835614223684 3.353781077977303 20.671036743580732 -6.8606330915224 1.1824167552137472 0.7212358421449085 3.4943616533939594 0.9544128508153069 0.2664941506790979 0.1461572739461622 0.3879149136660928 0.17573047630296515 0.41053581795172506 1.3783734794057692e-07 6.8606330915224 2.773125811249051 up IYK(ub)YIHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYKYIHK 7 1 Q15800;D6RDP9;D6R952;Q15800-2 Q15800 MSMO1 Methylsterol monooxygenase 1 1 10266900.0 877800.0 2348600.0 7040500.0 True False 729929.5931335143 2335947.625639402 8512635.998406013 1.0 3.2002369099893784 11.662270003141158 19.47739778701055 -6.945777512604198 0.6034239496783486 0.9053593262071582 14.392876492946428 0.998826870488181 0.15742664725645544 0.08522690657356824 0.04333035975991375 0.1610329706133687 0.7119320500011863 1.1329806362174241e-07 6.945777512604198 13.48751716673927 IYK(ub)YIHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYKYIHK 7 1 Q15800;D6RDP9;D6R952;Q15800-2 Q15800 MSMO1 Methylsterol monooxygenase 1 1 26166000.0 1492900.0 6314100.0 18359000.0 True False 1932588.4794585218 5962714.784460022 15017850.379247718 1.0 3.0853515105971616 7.770847512997419 20.88210303571436 -6.957706590167177 0.4666350131918002 0.8721090557769485 10.17508721631696 0.9996754500670031 0.05100684503485241 0.08053079850296498 0.024237283210602485 0.06438248903613811 0.386820877371266 1.1022837621667532e-07 6.957706590167177 9.302978160540011 IYLCDIGIPQQVFQEVGINYHSPFGCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYLCDIGIPQQVFQEVGINYHSPFGCK 27 0 Q96F86 Q96F86 EDC3 Enhancer of mRNA-decapping protein 3 0 68602000.0 26416000.0 21522000.0 20664000.0 False True 40075003.26828304 17681230.947846495 16579751.34264707 1.0 0.4412034811196167 0.41371802845912553 25.25619930224914 -13.747235146378669 0.431624250598339 9.99999999999989 0.41319545953188497 0.9998746767654375 0.0030240503263654684 25.435936625655412 0.22047313557427875 215.0940521067829 0.006481151519528288 1.7896366026828505e-14 13.747235146378669 -9.586804540468005 IYLDMLNVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYLDMLNVYK 10 0 O14980 O14980 XPO1 Exportin-1 0 17928200.0 5704200.0 6584700.0 5639300.0 False True 7478261.439551385 5602288.426959562 5055799.331985332 1.0 0.7491431627851244 0.6760661382130851 22.834271477930145 -13.999999999999998 0.1729241514948111 2.275053853652749 0.6135703244958542 0.9995084030283125 0.0030758115417215 12.121309039673127 0.13173667399711625 5.186084456691734 0.058029169239744424 1.0000000000000041e-14 13.999999999999998 -1.6614835291568948 IYLILEYAPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYLILEYAPR 10 0 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;J3KT86;Q96GD4-2;J3QR41 Q96GD4-5 AURKB Aurora kinase B 0 51869000.0 13952000.0 18941000.0 18976000.0 False True 21166204.027827296 15560830.56329154 15225385.282523757 1.0 0.7351734180977209 0.7193252631651325 24.33525922211281 -13.999999999999988 0.400719150596569 5.484797651869282 0.7184106816717829 0.9998387814332813 0.0016346076348692602 26.875844298534865 0.2087076392661124 104.82846796773632 0.004047043921927348 1.0000000000000286e-14 13.999999999999988 -4.766386970197499 IYLILEYAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYLILEYAPR 10 0 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;J3KT86;Q96GD4-2;J3QR41 Q96GD4-5 AURKB Aurora kinase B 0 5312220.0 3179900.0 1222500.0 909820.0 False True 2644227.7434555246 1215914.1498527497 1100059.1554676194 1.0 0.459837150132829 0.4160228475744083 21.334415008728058 -13.999999999999998 0.35598854891497667 7.893518981431801 0.4104408171538601 0.9997659508515103 0.004062792215247119 21.270656384010557 0.1925103317517727 111.19389525929284 0.01281139175486085 1.0000000000000041e-14 13.999999999999998 -7.4830781642779405 IYLILEYAPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYLILEYAPR 10 0 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;J3KT86;Q96GD4-2;J3QR41 Q96GD4-5 AURKB Aurora kinase B 0 41632000.0 13952000.0 14730000.0 12950000.0 False True 18061139.035036035 13910262.55128936 10593232.878220942 1.0 0.7701763728359232 0.5865207536286378 24.10638554420526 -6.973662038227595 0.14628661552578476 1.2249355277387801 0.12694642310611526 0.9999986955183353 0.00019310948944147683 0.0751313977008728 0.004455706779404649 0.009729925255184737 0.023267527497750743 1.0625220750911547e-07 6.973662038227595 -1.0979891046326649 IYLPYLHEWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYLPYLHEWK 10 0 F5H442;Q99816 F5H442 TSG101 Tumor susceptibility gene 101 protein 0 3850200.0 1159900.0 1209200.0 1481100.0 False True 1520640.1324875767 1028792.0734246837 1327849.9797144092 1.0 0.6765519674544619 0.873217766219423 20.53624734138465 -10.329915910162732 5.630175524857664 1.0000379937366835 0.7748848681123045 0.6359651926166598 0.08028847613851253 3.8296869336504524e-05 4.5580470793026114e-06 0.07775208434506432 0.025912994248068196 4.67825714807212e-11 10.329915910162732 -0.22515312562437895 IYLPYLHEWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYLPYLHEWK 10 0 F5H442;Q99816 F5H442 TSG101 Tumor susceptibility gene 101 protein 0 6390500.0 1159900.0 1990000.0 3240600.0 False True 1588746.3751188968 1902075.219950009 2475237.0222519753 1.0 1.197217661508536 1.5579812240746962 20.599457402907543 -6.961751703469531 0.4099998612601496 0.9822284986901116 1.7863586862736702 0.9998297499164713 0.0030145173063667033 0.07908120660600472 0.018862255307873613 0.004645481433977794 0.030121052834426152 1.092064517375858e-07 6.961751703469531 0.8041301875835586 IYLSCLEELMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYLSCLEELMK 11 0 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 2437020.0 561680.0 1172300.0 703040.0 False True 736367.9193168583 997397.4095896096 630296.164835877 1.0 1.3544824311668997 0.8559527761891285 19.49006724988802 -6.715739123368299 1.7745695554257026 1.2166371771182722 0.8569053536664816 0.49237328343274434 0.14925060807191884 0.36366252965639684 2.235691612660875 0.06684121143608414 0.16864811946641947 1.9242472591412093e-07 6.715739123368299 -0.35973182345179067 IYLSCLEELMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYLSCLEELMK 11 0 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 10136280.0 561680.0 3799800.0 5774800.0 False True 769348.2748312647 3631912.271741736 4410911.175739274 1.0 4.720764822067477 5.733308723811314 19.553277311410913 -9.373493790157738 0.41473119456018404 7.477361185719035e-20 5.852219666913593 0.9980815016935772 0.0891373705347194 0.7334850740269551 0.16766169702773648 1.4079866459269408 0.24550122615764117 4.231615603294233e-10 9.373493790157738 5.852219666913593 IYLSK(ub)GPNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYLSKGPNVK 10 1 Q9Y4C2-2;Q9Y4C2 Q9Y4C2-2 TCAF1 TRPM8 channel-associated factor 1 1 18147700.0 2610500.0 9371100.0 6166100.0 True False 3422390.780117961 7972968.408261691 5528091.121407748 1.0 2.329648751562755 1.6152717432277588 21.706573070340887 -10.096285822724669 5.3937715540911855 0.9999870149393872 1.9724602473958148 0.7118772266068483 0.29164319240140946 4.553995402766509e-05 7.631011227336849e-06 0.28238606951381634 0.09412743560016881 8.011506276658266e-11 10.096285822724669 0.9724732324564276 IYLSK(ub)GPNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYLSKGPNVK 10 1 Q9Y4C2-2;Q9Y4C2 Q9Y4C2-2 TCAF1 TRPM8 channel-associated factor 1 1 26917100.0 7563600.0 7510700.0 11842800.0 True False 7323497.658105314 10509761.677783085 8740815.403615516 1.0 1.4350740818700691 1.1935301698282894 22.804101404831986 -10.057094039274855 4.2498656211628125 0.9999697987606239 1.3143021257969025 0.6930226897990733 0.09860988939610503 12657247.88386278 7488186.637351632 3326.1374701425184 0.03375678809022165 8.768109417039484e-11 10.057094039274855 0.31433232703627867 IYLSK(ub)GPNVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYLSKGPNVK 10 1 Q9Y4C2-2;Q9Y4C2 Q9Y4C2-2 TCAF1 TRPM8 channel-associated factor 1 1 48754100.0 19761800.0 18458900.0 10533400.0 True False 29980095.381100714 15164765.07495604 8451468.873046763 1.0 0.5058277794711695 0.2819026679406271 24.83750163741132 -10.93882803570006 0.15516703790041048 1.9776919798501857 6.651228977216588e-18 0.9996303772737054 0.0057677137601654105 3.0674418872098994 0.08851452614864315 1.2755180297223414 0.19722097777868666 1.151256152893739e-11 10.93882803570006 -1.9776919798501857 IYLSK(ub)GPNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYLSKGPNVK 10 1 Q9Y4C2-2;Q9Y4C2 Q9Y4C2-2 TCAF1 TRPM8 channel-associated factor 1 1 15751000.0 2610500.0 6369500.0 6771000.0 True False 3575672.39610991 6088074.428880203 5171829.253122303 1.0 1.7026376453009553 1.4463934835721817 21.76978313186378 -10.418279258025555 5.582652552757901 0.9996750945373608 1.5745155644365705 0.8701713852444505 0.1046112409671249 0.0004232683028612355 4.410501235870111e-05 0.10134489459074715 0.033763132840979405 3.816987537487483e-11 10.418279258025555 0.5748404698992097 IYLSK(ub)GPNVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYLSKGPNVK 10 1 Q9Y4C2-2;Q9Y4C2 Q9Y4C2-2 TCAF1 TRPM8 channel-associated factor 1 1 29044300.0 7563600.0 14689300.0 6791400.0 True False 6289468.524293279 14610165.825302254 8211450.340114279 1.0 2.3229571415883563 1.3055873176560597 22.584506680266262 -10.165726093164828 4.639847130991765 0.9998903859486576 1.8142722296308995 0.4606613771943827 0.41533949141960586 0.0004710132028551762 8.469037268104183e-05 0.40220429595000134 0.1340502444366672 6.827691766595759e-11 10.165726093164828 0.8143818436822419 IYLSK(ub)GPNVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYLSKGPNVK 10 1 Q9Y4C2-2;Q9Y4C2 Q9Y4C2-2 TCAF1 TRPM8 channel-associated factor 1 1 42344300.0 19761800.0 16992800.0 5589700.0 True False 25582039.66331528 16047135.742128275 4572431.9551653685 1.0 0.6272813252314636 0.17873602008843137 24.60862795950377 -7.507703685174877 0.4152745414632006 1.0334071848935384 2.591143268822359e-22 0.9986965076812025 0.012122089910205885 0.11866111030837821 0.05165994848132158 0.019662342210145678 0.067086722282603 3.106678521178912e-08 7.507703685174877 -1.0334071848935384 down IYLTADNLVLNLQDESFTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYLTADNLVLNLQDESFTR 19 0 Q99623;J3KPX7;Q99623-2 Q99623 PHB2 Prohibitin-2 0 10094300.0 6184500.0 0.0 3909800.0 False True 5988176.4327241415 0.0 2885706.0885141958 1.0 0.0 0.481900645536162 22.51368529821321 -10.027495555083917 6.178370392987953 1.0000007443505787 0.2409503227680572 0.7678731565458324 0.19673511471366234 2.0171668558514444e-06 3.176923254806676e-07 0.1904881416243858 0.06349598524167148 9.386516435324799e-11 10.027495555083917 -0.7590504215825216 IYLTADNLVLNLQDESFTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYLTADNLVLNLQDESFTR 19 0 Q99623;J3KPX7;Q99623-2 Q99623 PHB2 Prohibitin-2 0 54969200.0 9303200.0 30220000.0 15446000.0 False True 14113634.555023145 24827004.890062314 12393091.329777714 1.0 1.7590794768896862 0.8780935400773093 23.750586224031014 -6.678678741509237 1.90619805086061 1.4808295356627978 0.8814468500478584 0.3182901861760017 0.3218061899894681 0.44144401913002657 3.099967596272813 0.1355089090708013 0.35805206210642265 2.0956620962953037e-07 6.678678741509237 -0.5993826856149395 IYLTADNLVLNLQDESFTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYLTADNLVLNLQDESFTR 19 0 Q99623;J3KPX7;Q99623-2 Q99623 PHB2 Prohibitin-2 0 22857400.0 9303200.0 7240800.0 6313400.0 False True 12043175.793488191 6837843.114825248 5164425.980954437 1.0 0.5677774062322087 0.4288259234534191 23.521712546123464 -13.999999999999998 0.158750282874696 3.1231099582633943 0.2903285815831346 0.9995397108672076 0.005217927759547698 12.001553390150672 0.12586754013633636 7.846646170414178 0.12603253322869604 1.0000000000000041e-14 13.999999999999998 -2.8327813766802596 IYLTLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYLTLLR 7 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 16614900.0 4300600.0 3773500.0 8540800.0 False True 5638128.247069649 3210508.5089877923 7657079.945138627 1.0 0.5694280740521318 1.358088998617281 22.42678486371124 -6.758462872242325 1.6183121696642258 0.7494221560531434 1.3607479390743469 0.6846432281434847 0.18106158488249133 0.28550576578784476 1.473339473222914 0.08829266532369186 0.21249976234265097 1.74396244213077e-07 6.758462872242325 0.6113257830212034 IYLTLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYLTLLR 7 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 17242700.0 4900100.0 4526300.0 7816300.0 False True 4744549.007679126 6333675.194342674 5768976.546026265 1.0 1.334937247795633 1.215916736593739 22.177839527949427 -10.19756066964726 4.673826565129392 0.9999510744838639 1.275426992196431 0.8771523322681518 0.04858992023433377 2.477658879838536e-05 4.253742978813984e-06 0.047055331970656145 0.015682329320907844 6.345112554547175e-11 10.19756066964726 0.2754759177125671 IYLTLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYLTLLR 7 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 10882000.0 2708800.0 4074800.0 4098400.0 False True 4109447.639806378 3347620.103442284 3288349.443607466 1.0 0.8146155875099582 0.8001925640211833 21.970513060344164 -13.99999999999999 0.36209453465674213 3.4575008706779364 0.7985076376575089 0.999777056431337 0.0013584567499038691 21.924495136756388 0.19464145357379717 41.67564553569505 0.004133650568210991 1.0000000000000246e-14 13.99999999999999 -2.6589932330204276 IYLTLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYLTLLR 7 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 21093600.0 4300600.0 5256000.0 11537000.0 False True 5890648.039345067 5023772.540732291 8812198.211973418 1.0 0.8528386872169743 1.4959641372417107 22.489994925234132 -6.846521336555512 1.2517294300534507 0.9216439714941559 1.5200038836044025 0.9350954157591829 0.07009205646922824 0.1613230146883126 0.48815534467498584 0.0438532382335406 0.1012807360296629 1.4238972899437098e-07 6.846521336555512 0.5983599121102466 IYLTLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYLTLLR 7 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 10942000.0 4900100.0 2124900.0 3917000.0 False True 4074650.2612366457 2113452.7419403745 4736026.589838271 1.0 0.5186832259068407 1.1623148702830999 21.958244803383703 -6.706578856712981 1.8076788014198137 0.7030567999268764 1.1606349966726275 0.4486568714952398 0.202937717879775 0.3820235165929655 2.43129126603991 0.08941734637622387 0.22808573838936252 1.9652651065618673e-07 6.706578856712981 0.45757819674575106 IYLTLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYLTLLR 7 0 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 0 10097400.0 2708800.0 3881400.0 3507200.0 False True 3506594.998430735 3665396.677975187 2868925.586910925 1.0 1.0452865756140983 0.8181513942142794 21.741639382436613 -6.8548708762003 1.211303051103241 1.0243089410316892 0.8081786184438859 0.9471033672007932 0.022575001578867406 0.1521805815184816 0.4272329809632131 0.014562747860461689 0.03382244798004705 1.3967835889776587e-07 6.8548708762003 -0.2161303225878033 IYLYLTK(ub)VGISPDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYLYLTKVGISPDK 14 1 P41250 P41250 GARS Glycine--tRNA ligase 1 8512000.0 2078700.0 3766400.0 2666900.0 True False 2725195.8301594346 3204467.8013122138 2390954.7707112 1.0 1.175866983887444 0.8773515445204977 21.37792847372702 -6.747048210047723 1.6606293827963317 1.1037771151097724 0.8768845044724696 0.6362178447331357 0.0738924867933915 0.3052282653337644 1.6551232287305413 0.03516351498765672 0.08563844367787338 1.7904070939633442e-07 6.747048210047723 -0.22689261063730282 IYLYLTK(ub)VGISPDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYLYLTKVGISPDK 14 1 P41250 P41250 GARS Glycine--tRNA ligase 1 22330200.0 8363600.0 6805500.0 7161100.0 True False 8098102.096003177 9522971.640213655 5285393.081604938 1.0 1.1759510472106451 0.6526705910775745 22.949152401085023 -6.816013614667785 1.3890045842951675 1.095235584763173 0.6421919893849504 0.8749750877140565 0.07687505268752291 0.1987121649179072 0.7543679392426855 0.043503111444077903 0.1003911506054157 1.527518171425585e-07 6.816013614667785 -0.4530435953782226 IYLYLTK(ub)VGISPDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYLYLTKVGISPDK 14 1 P41250 P41250 GARS Glycine--tRNA ligase 1 38255500.0 9695500.0 13368000.0 15192000.0 True False 14708782.335994812 10982375.955339288 12189294.541109843 1.0 0.7466543255904744 0.828708608412855 23.81017448248786 -10.452884399524411 8.505881322272602 1.000004712892542 0.7876814670016647 0.8992659856485979 0.0334985206874752 2.9939709191181858e-06 1.9257633256072435e-07 0.03243552306346024 0.010811601062098001 3.524646775810768e-11 10.452884399524411 -0.21232324589087725 IYLYLTK(ub)VGISPDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYLYLTKVGISPDK 14 1 P41250 P41250 GARS Glycine--tRNA ligase 1 8434700.0 2078700.0 3369100.0 2986900.0 True False 2847251.5647552838 3220242.0218761736 2281455.7371364655 1.0 1.1310001763588275 0.801283513328248 21.441138535249912 -6.798882218634874 1.4603483264689998 1.07238040051781 0.7968497816421516 0.8289234177717582 0.0560650695208118 0.22234774995021364 0.9362463015087729 0.030203505215918466 0.0702944621628047 1.5889776234667503e-07 6.798882218634874 -0.27553061887565833 IYLYLTK(ub)VGISPDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYLYLTKVGISPDK 14 1 P41250 P41250 GARS Glycine--tRNA ligase 1 21166600.0 8363600.0 6214700.0 6588300.0 True False 6954703.970302409 6181220.177578641 7965883.0691425875 1.0 0.8887826432258432 1.1453949877892804 22.7295576765193 -6.788923259474032 1.5006359931914757 0.937751756129798 1.1480429887300108 0.7977861077673858 0.04724845595918721 0.23697816600016855 1.054270217710023 0.024784251890118233 0.0580717455195398 1.6258360181811887e-07 6.788923259474032 0.21029123260021276 IYLYLTK(ub)VGISPDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYLYLTKVGISPDK 14 1 P41250 P41250 GARS Glycine--tRNA ligase 1 27531800.0 9695500.0 11443000.0 6393300.0 True False 12551015.876877287 10806186.99079457 5229785.000797681 1.0 0.8609810629514689 0.41668220740860534 23.58130080458031 -6.950019954563036 0.5586229218232934 1.0058532470090122 0.2506263419747901 0.9992028591771525 0.007023746093490227 0.08347769961326383 0.03592897997118621 0.0075416387229741404 0.036922333221222736 1.1219669020153212e-07 6.950019954563036 -0.7552269050342222 down IYLYTLNDNAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYLYTLNDNAR 11 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 35136400.0 9278700.0 10877000.0 14980700.0 False True 12164465.555058608 9254193.99821393 13430640.869021429 1.0 0.7607563157072332 1.1040880347954358 23.536169601174755 -6.719328594990267 1.7616666449120226 0.8543427151118793 1.1035347794916013 0.5093601074519644 0.10068309249761834 0.35663197544983094 2.162667059323225 0.04538537504318021 0.11402710261866841 1.9084087758840116e-07 6.719328594990267 0.24919206437972197 IYLYTLNDNAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYLYTLNDNAR 11 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 21845100.0 8674000.0 5414100.0 7757000.0 False True 8398648.617907548 7575978.364158514 5725208.9949881425 1.0 0.9020473065160814 0.6816821676264544 23.001725779467094 -6.957680779893212 0.46697821320631533 1.0059946740046932 0.5687468212277902 0.9996742554813435 0.0024025452134826012 0.08054032186287349 0.024273573814826383 0.003029890588064067 0.018192171858483944 1.1023492732254823e-07 6.957680779893212 -0.43724785277690303 IYLYTLNDNAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYLYTLNDNAR 11 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 36438700.0 9278700.0 12088000.0 15072000.0 False True 12709286.137439186 11553912.190329522 11512304.017583711 1.0 0.9090921445456998 0.9058183042767927 23.599379662697647 IYLYTLNDNAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYLYTLNDNAR 11 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 17381200.0 8674000.0 6432500.0 2274700.0 False True 7212815.323353952 6397846.845748725 2750329.252975522 1.0 0.8870110433901603 0.38131147543323235 22.78213105490137 -6.942304142105897 0.6377754738707393 1.0055284848936652 0.2351744041844627 0.9984502983211675 0.01058972345503396 0.08673122419567557 0.04994114127199714 0.010497993671423948 0.04310215788049444 1.1420782423343009e-07 6.942304142105897 -0.7703540807092025 down IYNDDK(ub)NTYIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYNDDKNTYIR 11 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 6454970.0 741970.0 1132100.0 4580900.0 True False 972729.8552477 963195.0928912377 4106912.411095632 1.0 0.9901979338816178 4.222048278809979 19.891679672446376 -6.906216042554435 0.9211230684872677 0.8875716699186278 4.607587850963803 0.9894134540987937 0.1565180871379891 0.10697352887312693 0.15273577285008055 0.12579279667732163 0.3387801560532177 1.2410347933544445e-07 6.906216042554435 3.7200161810451755 up IYNDDK(ub)NTYIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYNDDKNTYIR 11 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 8171500.0 1080800.0 1345600.0 5745100.0 True False 1046490.595600009 1882905.0972113 4240285.960694389 1.0 1.7992565868513417 4.051910240304842 19.997127916042313 -6.952845057870226 0.526683342919067 0.9636048509000953 4.989245267496541 0.9994060609865364 0.031491388857138515 0.08236300821915302 0.03138687430634101 0.03530776906235431 0.1862057386098487 1.1146921485217977e-07 6.952845057870226 4.0256404165964454 IYNDDK(ub)NTYIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYNDDKNTYIR 11 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 7008800.0 741970.0 827430.0 5439400.0 True False 1016296.3599853159 790871.4066548926 4154725.7479594448 1.0 0.7781897464105053 4.088104524963048 19.954889733969267 -6.890865054531945 1.0172184858765092 0.8258257252110354 4.377695401856103 0.9814473655968438 0.20577549404062795 0.11844537078015366 0.21775443433079164 0.15395457359841855 0.3850382513486907 1.2856860906672987e-07 6.890865054531945 3.551869676645068 up IYNDDK(ub)NTYIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYNDDKNTYIR 11 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 8798000.0 1080800.0 2666700.0 5050500.0 True False 898733.0875583295 2652333.9578014906 6106536.199126424 1.0 2.9511920663868394 6.794604853946805 19.77753319147659 -6.960341600852127 0.4305929954964269 0.8482905044052991 9.045039243356905 0.9997826583083779 0.035489847942064896 0.07957932589004667 0.020682145992736843 0.05014589161742268 0.31907847480193446 1.0956160838362376e-07 6.960341600852127 8.196748738951607 IYPHGLVLLDLQSYDGDAQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYPHGLVLLDLQSYDGDAQGK 21 0 P52788;H7C2R7 P52788 SMS Spermine synthase 0 12037400.0 3897400.0 3606300.0 4533700.0 False True 3773679.170328899 5046314.396606054 3346187.9619153957 1.0 1.3372399106642225 0.886717659578823 21.84754034280558 -6.706361292189935 1.8082528344758204 1.2080941565720595 0.8878886805966434 0.44778468590528175 0.1421945813366832 0.3824293094291426 2.435233661530346 0.06263394004822168 0.15982107215539765 1.9662498740403382e-07 6.706361292189935 -0.32020547597541615 IYPHGLVLLDLQSYDGDAQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYPHGLVLLDLQSYDGDAQGK 21 0 P52788;H7C2R7 P52788 SMS Spermine synthase 0 6073370.0 1099600.0 975770.0 3998000.0 False True 1506151.835572672 932657.2549601112 3053754.7413946157 1.0 0.6192318947747353 2.027521176331808 20.522435785141443 -6.834699329979507 1.3067056086800208 0.797102531424702 2.069207600386195 0.914960107278759 0.17345263849656148 0.17508515835164004 0.5829809516941223 0.10416521066224321 0.23975189178887663 1.4631898169778443e-07 6.834699329979507 1.272105068961493 up IYPTFLHLHGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYPTFLHLHGK 11 0 Q08945;E9PMD4 Q08945 SSRP1 FACT complex subunit SSRP1 0 251767400.0 89605800.0 80104800.0 82056800.0 False True 117474071.54380149 68153476.08606479 73566349.48040593 1.0 0.5801576057628429 0.6262347811191332 26.807767124544277 -10.49836667863925 9.512405825678648 1.0000067117550735 0.6031961937140834 0.9899882184068093 0.018810928068609154 2.677608544377049e-06 1.4117895832927766e-07 0.01821391043616236 0.0060712009280357426 3.174192940025321e-11 10.49836667863925 -0.3968105180409901 IYPTFLHLHGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYPTFLHLHGK 11 0 Q08945;E9PMD4 Q08945 SSRP1 FACT complex subunit SSRP1 0 181537400.0 52740500.0 33064700.0 95732200.0 False True 51066281.696190126 46267607.14013259 70657064.91556062 1.0 0.9060304687032745 1.3836344172446786 25.605867679718468 -6.855613617613338 1.207629550413083 0.949496632220635 1.404905446335322 0.9480887479955173 0.04706932415623712 0.15139100331426317 0.42204373356856784 0.030448487386549445 0.07076390485477736 1.3943968158789528e-07 6.855613617613338 0.45540881411468714 IYPTFLHLHGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYPTFLHLHGK 11 0 Q08945;E9PMD4 Q08945 SSRP1 FACT complex subunit SSRP1 0 77167000.0 34300000.0 23185000.0 19682000.0 False True 52035607.66588852 19047455.604768172 15791844.07307294 1.0 0.36604656809368946 0.30348149625674775 25.632995853283422 -13.999999999999998 0.32739337768355065 7.793665101392538 0.2920602443338884 0.9997094058694103 0.005363501728334515 18.605595285389153 0.18283367518810623 86.91791216877019 0.020246534004575732 1.0000000000000041e-14 13.999999999999998 -7.501604857058649 IYPTFLHLHGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYPTFLHLHGK 11 0 Q08945;E9PMD4 Q08945 SSRP1 FACT complex subunit SSRP1 0 187916500.0 89605800.0 41454700.0 56856000.0 False True 122735485.76569438 39623094.28163904 43427783.78607614 1.0 0.3228332379543491 0.3538323372018183 26.87097718606717 -9.954740448847572 5.166071737101516 1.0000022532322423 0.3383327876128533 0.9983565142933669 0.01265532929715623 9005443.949952321 8676499.967778513 227.2148620709515 0.004332256314702241 1.1098378990846904e-10 9.954740448847572 -0.6616694656193891 IYPTFLHLHGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYPTFLHLHGK 11 0 Q08945;E9PMD4 Q08945 SSRP1 FACT complex subunit SSRP1 0 115604100.0 52740500.0 41922200.0 20941400.0 False True 43856062.55030541 41696356.787694834 25320149.9179064 1.0 0.950754681633052 0.5773466299867377 25.386272955152744 -6.931107685073827 0.7376464840091552 1.0054515756754818 0.4984806433703624 0.9967514139400642 0.010755638387441924 0.0920669444392918 0.07489331527703012 0.009864227248281239 0.03358361635820473 1.1719047509958706e-07 6.931107685073827 -0.5069709323051195 IYPTFLHLHGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYPTFLHLHGK 11 0 Q08945;E9PMD4 Q08945 SSRP1 FACT complex subunit SSRP1 0 118613000.0 34300000.0 47590000.0 36723000.0 False True 44402026.15408087 44941574.66502789 30039790.809799775 1.0 1.0121514389698054 0.6765409917456864 25.40412217537587 -6.898499794781687 0.9707189544219541 1.0145336141277326 0.6423688037524209 0.9858045800148766 0.01851784173379821 0.11251744932565726 0.18372009392400818 0.014347055941033526 0.03705478270169729 1.263281700749038e-07 6.898499794781687 -0.3721648103753117 IYQNIQDGSLDLNAAESGVQHK(ub)PSAPQGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYQNIQDGSLDLNAAESGVQHKPSAPQGGR 30 1 P61106 P61106 RAB14 Ras-related protein Rab-14 1 12343200.0 4651200.0 3341300.0 4350700.0 True False 4503550.201938164 4675498.5146493185 3211121.151797716 1.0 1.0381806141823742 0.7130199526621833 22.102631312852868 -6.877628239774469 1.0929901168639298 1.022994736145057 0.6910033246232007 0.9717192340537482 0.024405078656071277 0.1297494328790387 0.285185478886358 0.0172359868488216 0.04143954079922734 1.325475669546522e-07 6.877628239774469 -0.3319914115218564 IYQNIQDGSLDLNAAESGVQHK(ub)PSAPQGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYQNIQDGSLDLNAAESGVQHKPSAPQGGR 30 1 P61106 P61106 RAB14 Ras-related protein Rab-14 1 12197900.0 4651200.0 4133300.0 3413400.0 True False 3867678.883097065 4111033.092504185 4127126.1582215903 1.0 1.0629199622726313 1.067080872783516 21.883036588287144 -13.999998007770623 0.38597623360129024 0.0303654614657957 1.0674088469599305 0.9998169388954755 0.0004151760422589116 24.805883182753416 0.20319181445673393 20.03472943953551 0.001107789244877593 1.000004587288187e-14 13.999998007770623 1.0370433854941348 IYQTFVALAAQLQSIHENVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYQTFVALAAQLQSIHENVK 20 0 Q5JRG1;H7BYF2;Q9BVL2-2;Q9BVL2-3;Q9BVL2 Q5JRG1 NUPL1 Nucleoporin p58/p45 0 56674690.0 22631000.0 12422690.0 21621000.0 False True 21912591.29258309 17383134.900472526 15957811.483903382 1.0 0.7932943515610734 0.7282484883156989 24.38525676578768 -13.999999999999998 0.1618411468257343 2.022057803209662 0.6655866196635363 0.9995316444628461 0.0025073306291109087 12.022487979237455 0.12719123231260795 3.8567493751671926 0.057245697266439535 1.0000000000000041e-14 13.999999999999998 -1.3564711835461258 IYQTFVALAAQLQSIHENVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYQTFVALAAQLQSIHENVK 20 0 Q5JRG1;H7BYF2;Q9BVL2-2;Q9BVL2-3;Q9BVL2 Q5JRG1 NUPL1 Nucleoporin p58/p45 0 29528800.0 8475800.0 10964000.0 10089000.0 False True 12858408.26398069 9007388.537877003 8094904.727834205 1.0 0.7005057199115955 0.6295417412207904 23.616208727422492 -13.999999999955799 0.20227670197879905 2.6794614126782896 0.5844747151721369 0.9994871681400871 0.003635662075640268 12.576829557919249 0.14259864629219604 8.364920907502448 0.04443089149478949 1.0000000001017768e-14 13.999999999955799 -2.094986697506153 IYQTFVALAAQLQSIHENVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYQTFVALAAQLQSIHENVK 20 0 Q5JRG1;H7BYF2;Q9BVL2-2;Q9BVL2-3;Q9BVL2 Q5JRG1 NUPL1 Nucleoporin p58/p45 0 47835000.0 22631000.0 9153000.0 16051000.0 False True 18818679.22329067 9103690.972271757 19407189.888561174 1.0 0.48375823107738103 1.031272687008881 24.165662041221957 -10.124574765360675 13.660036944349637 1.0000001387850894 0.757515459043131 0.20730954456545259 0.22352184063830133 0.0 0.0 0.2164240915764358 0.07214136385881192 7.50628819538884e-11 10.124574765360675 -0.24248467974195842 IYQTFVALAAQLQSIHENVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYQTFVALAAQLQSIHENVK 20 0 Q5JRG1;H7BYF2;Q9BVL2-2;Q9BVL2-3;Q9BVL2 Q5JRG1 NUPL1 Nucleoporin p58/p45 0 20177100.0 8475800.0 7075500.0 4625800.0 False True 10972090.182995873 6681742.205135631 3783951.8647161713 1.0 0.6089762382276752 0.3448706492205465 23.38733504951494 -8.224906061417801 0.1931224782502259 1.2906151247900652 3.638278967484063e-07 0.9998103656041968 0.0037060324175560984 0.08684056556653583 0.04049768047780843 0.10938514096711334 0.11685137125929856 5.957910001266632e-09 8.224906061417801 -1.2906147609621685 down IYQWINELSSPETR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYQWINELSSPETR 14 0 Q92600;Q92600-3;Q92600-2;F8WBZ6 Q92600 RQCD1 Cell differentiation protein RCD1 homolog 0 4054670.0 839570.0 1643600.0 1571500.0 False True 1100684.4004074445 1398381.2867026192 1408896.2548924412 1.0 1.2704652543317367 1.2800183725424878 20.069969433106557 -12.083096708456203 0.5112150951809132 1.964944919688598e-05 1.2794574463092157 0.9999142074283994 0.0012023311293309846 7.135646025885139 0.2535989232089107 7.774942359185808 0.001905671349393532 8.25854028379697e-13 12.083096708456203 1.2794377968600188 IYQYVINK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYQYVINK 8 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9 A0A3B3IRI2 CTPS1 CTP synthase 1 0 7493700.0 1666100.0 3399200.0 2428400.0 False True 2184273.234535353 2892052.609977825 2177132.4628576543 1.0 1.324034266524826 0.9967308248964478 21.058721906100672 -9.187087014517907 13.569089619923682 1.0000292921896776 1.1603825457106371 0.242509585765316 0.13362107157795503 0.0 0.0 0.1293780457473705 0.04312601524912348 6.499994444912322e-10 9.187087014517907 0.16035325352095953 IYQYVINK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYQYVINK 8 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9 A0A3B3IRI2 CTPS1 CTP synthase 1 0 6825230.0 2509600.0 884530.0 3431100.0 False True 2429934.1216855873 1237727.4417630148 2532391.979206367 1.0 0.5093666658355465 1.042164870482047 21.21248577056023 -6.6646486219154815 1.9565303603757354 0.6853972751034739 1.0399595515989264 0.255481291719608 0.20867157887931234 0.47352635108990615 3.489325231111765 0.08602594180005226 0.23143990285296884 2.164469039630145e-07 6.6646486219154815 0.35456227649545247 IYQYVINK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYQYVINK 8 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9 A0A3B3IRI2 CTPS1 CTP synthase 1 0 3992260.0 2509600.0 830330.0 652330.0 False True 2086843.5941306292 825856.8474824001 788729.1869668637 1.0 0.3957444869395921 0.37795318690160157 20.992891045994508 IYQYVINK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYQYVINKER 10 1 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9 A0A3B3IRI2 CTPS1 CTP synthase 1 1 1729370.0 1028100.0 701270.0 0.0 True False 995463.5282534879 981290.7680747387 0.0 1.0 0.9857626524965561 0.0 19.92500893395696 -7.034671203279632 1.0716513492648068 1.017645716180447 1.9209058195196632e-18 0.9868494232756327 0.053678079313809454 0.08654160587660764 0.19230708608011063 0.042133413678550787 0.07593511022887556 9.23270154233486e-08 7.034671203279632 -1.017645716180447 down IYQYVINK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYQYVINKER 10 1 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9 A0A3B3IRI2 CTPS1 CTP synthase 1 1 3631180.0 1028100.0 909680.0 1693400.0 True False 854910.7025524788 904779.3732826578 2047482.1106030454 1.0 1.0583320229601616 2.394966052582972 19.705414209391236 -6.916048498376023 0.8535137847150914 0.9661031064851204 2.5920718746774254 0.9930111387851216 0.053861808925968105 0.10055304237631511 0.11807254759416333 0.04546129980428887 0.13143434333120152 1.2132533569104554e-07 6.916048498376023 1.625968768192305 up IYSLFTLSLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYSLFTLSLLK 11 0 A0A0A0MSJ9;Q15283-2;Q15283 A0A0A0MSJ9 RASA2 Ras GTPase-activating protein 2 0 19400000.0 5721700.0 5272500.0 8405800.0 False True 8680237.2123007 4331581.18076947 6744389.945606984 1.0 0.4990164525263455 0.776982216113813 23.04930303829965 -10.128794886036578 5.411077071396535 1.000006991193982 0.6379993343199536 0.6933819709711492 0.11347904779251317 9.571158149823148e-06 1.540939288243139e-06 0.10987773745997695 0.0366252051869252 7.43370143036804e-11 10.128794886036578 -0.36200765687402836 IYSLFTLSLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYSLFTLSLLK 11 0 A0A0A0MSJ9;Q15283-2;Q15283 A0A0A0MSJ9 RASA2 Ras GTPase-activating protein 2 0 16201900.0 5721700.0 4697000.0 5783200.0 False True 7406853.4415686345 4435607.821005169 4730716.940643036 1.0 0.5988518412031371 0.6386945520068448 22.8204293603921 -9.94316932006794 7.061365580003497 1.0000000131376345 0.6187731970527675 0.9918745213073574 0.01626571857306271 3.3751278742478416e-09 4.985188557963396e-10 0.015749214756253276 0.00524973809563028 1.1398053206187836e-10 9.94316932006794 -0.3812268160848671 IYSLK(ub)IECGPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYSLKIECGPK 11 1 I3L0A0;Q13404;Q13404-7;Q13404-2;Q13404-1;G3V2F7;A0A0A0MSL3;Q13404-6 I3L0A0 TMEM189-UBE2V1;UBE2V1 Ubiquitin-conjugating enzyme E2 variant 1 1 8814100.0 2914700.0 3046900.0 2852500.0 True False 3821199.925994951 2592314.3967231773 2557350.6631121146 1.0 0.6784032363991527 0.6692533007014126 21.865594311106463 IYSLK(ub)IECGPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYSLKIECGPK 11 1 I3L0A0;Q13404;Q13404-7;Q13404-2;Q13404-1;G3V2F7;A0A0A0MSL3;Q13404-6 I3L0A0 TMEM189-UBE2V1;UBE2V1 Ubiquitin-conjugating enzyme E2 variant 1 1 17079000.0 4957400.0 7842900.0 4278700.0 True False 7520738.234486159 6443273.218142606 3433013.0695791733 1.0 0.8567341419486104 0.4564728837173427 22.84244285289704 -6.953039313271003 0.5244158485965789 1.0065767093343816 0.2886327044915323 0.9994187236730411 0.005545547331861309 0.0822877627278895 0.031085407997273357 0.006239137614293271 0.03307716805474487 1.1141936698181166e-07 6.953039313271003 -0.7179440048428494 down IYSLK(ub)IECGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYSLKIECGPK 11 1 I3L0A0;Q13404;Q13404-7;Q13404-2;Q13404-1;G3V2F7;A0A0A0MSL3;Q13404-6 I3L0A0 TMEM189-UBE2V1;UBE2V1 Ubiquitin-conjugating enzyme E2 variant 1 1 9670100.0 2914700.0 3205000.0 3550400.0 True False 3992343.3568058047 3063392.5024823076 2711868.6427832535 1.0 0.767316893538252 0.6792673877010834 21.928804372629354 -13.999999999999961 0.13476927039866107 2.1074489025464347 0.5631158596460321 0.9996245844735354 0.002621587639570154 11.93223853352152 0.11460681441199708 3.4868346022499397 0.10351576488009445 1.00000000000009e-14 13.999999999999961 -1.5443330429004027 IYSLK(ub)IECGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYSLKIECGPK 11 1 I3L0A0;Q13404;Q13404-7;Q13404-2;Q13404-1;G3V2F7;A0A0A0MSL3;Q13404-6 I3L0A0 TMEM189-UBE2V1;UBE2V1 Ubiquitin-conjugating enzyme E2 variant 1 1 7000500.0 2497700.0 1753600.0 2749200.0 True False 2076948.2168712434 1744153.0087376542 3324045.0091354037 1.0 0.8397672096828112 1.6004467430308937 20.98603381622683 -6.8516820946668195 1.226924767826374 0.9143555166643417 1.6318611324362717 0.9427235180203076 0.07836019441774571 0.15561287144923913 0.44992883736119577 0.049953455445933416 0.1157278936519237 1.4070771334490256e-07 6.8516820946668195 0.7175056157719301 IYSLSCGK(ub)SLPEWLSDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYSLSCGKSLPEWLSDR 17 1 Q9BSC4;Q9BSC4-2;Q9BSC4-4 Q9BSC4 NOL10 Nucleolar protein 10 1 45823900.0 15360000.0 7980900.0 22483000.0 True False 23302242.96641535 6556646.039943694 18039225.19535102 1.0 0.28137403122066584 0.7741411511909081 24.4739654929444 -9.852736738551842 6.050427452430347 1.0000000540420526 0.5277575912068311 0.5504758622603421 0.20117133432584183 1.467048312550693e-07 2.7823636292317735e-08 0.1947833301139213 0.06492776896468487 1.403664322607799e-10 9.852736738551842 -0.47224246283522153 IYSLSCGK(ub)SLPEWLSDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYSLSCGKSLPEWLSDR 17 1 Q9BSC4;Q9BSC4-2;Q9BSC4-4 Q9BSC4 NOL10 Nucleolar protein 10 1 34264800.0 15360000.0 10887000.0 8017800.0 True False 19883822.79086534 10281128.87955786 6558642.669575273 1.0 0.5170599732100322 0.3298481755021637 24.24509181503685 -13.999999999999998 0.13113402869783483 3.2955018757243817 0.07140805358548089 0.9996405129624899 0.00535297960312263 11.935148261154776 0.11272268375469623 7.0545080996059495 0.22993996583108123 1.0000000000000041e-14 13.999999999999998 -3.224093822138901 IYTTK(ub)IKPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYTTKIKPR 9 2 Q09666;E9PLK4 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 25534400.0 6351700.0 9873100.0 9309600.0 True False 8327140.209950296 8400071.965042384 8346331.895988976 1.0 1.0087583195735002 1.0023047151308617 22.989389685166586 -6.5680062156241075 2.3161341763876737 1.006007231936064 1.0023182071980863 0.0 0.0038165791860026795 0.7362078268570871 7.412436958315333 0.0013949518430141836 0.0042772812141527485 2.703919665324436e-07 6.5680062156241075 -0.0036890247379777197 IYTTK(ub)IKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYTTKIKPR 9 2 Q09666;E9PLK4 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 51139500.0 8435500.0 17388000.0 25316000.0 True False 8167719.669859258 24331119.077222124 18684980.13627945 1.0 2.978936601731017 2.287661782177867 22.96150192062263 -10.211917043740167 5.469508901799066 0.9999200830312863 2.633299191954593 0.8815636731189979 0.28221176332382086 0.0002750325235881426 3.9629892570895195e-05 0.2732634546139384 0.09108345495467186 6.138792534043666e-11 10.211917043740167 1.633379108923307 IYTTK(ub)IKPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYTTKIKPR 9 2 Q09666;E9PLK4 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 71424000.0 10233000.0 14119000.0 47072000.0 True False 15524209.132508364 11599354.137749499 37768198.5676095 1.0 0.7471784255637185 2.432858140806752 23.888016437670444 -6.868715943170834 1.1409362226925772 0.8580794724754234 2.5291711654840925 0.963381121935263 0.14203886017380443 0.1380883077536555 0.3367714273635011 0.09669386031549493 0.22841865591832927 1.3529571958350028e-07 6.868715943170834 1.6710916930086692 up IYTTK(ub)IKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYTTKIKPR 9 2 Q09666;E9PLK4 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 25197700.0 6351700.0 7112000.0 11734000.0 True False 8700095.138238389 6797768.323761049 8962670.869315773 1.0 0.7813441365581978 1.0301807884747511 23.052599746689477 -6.67459573614941 1.9207518044419294 0.8609929107577886 1.029205973915985 0.2997459695144734 0.09278216318436351 0.45062537809130004 3.209244053880126 0.03882551462478186 0.10312683974198389 2.1154573010965946e-07 6.67459573614941 0.16821306315819629 IYTTK(ub)IKPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYTTKIKPR 9 2 Q09666;E9PLK4 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 46347500.0 8435500.0 27362000.0 10550000.0 True False 7014492.006012488 27214595.475068215 12755956.222311422 1.0 3.879767123797584 1.8185146139417687 22.741907196056907 -8.981503090953076 12.019966830117946 1.0000345700252107 2.8491408876636584 0.5176168841639895 0.8415028136008834 0.0 0.0 0.8147815956082325 0.2715938652027441 1.043510705846085e-09 8.981503090953076 1.8491063176384477 IYVASVHQDLSDDDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYVASVHQDLSDDDIK 16 0 A0A0J9YYL3;Q9UHX1-2;Q9UHX1-6;Q9UHX1-4;A0A0J9YVP6;Q9UHX1;Q9UHX1-5;Q9UHX1-3;A0A0J9YXX5;A0A0J9YXJ8;A0A0J9YVR6;E9PQ56;A0A0J9YWM1;H0YEM1;E9PN18 A0A0J9YYL3 PUF60 Poly(U)-binding-splicing factor PUF60 0 25330000.0 4795400.0 9829600.0 10705000.0 False True 6286815.838719659 8363061.995480698 9597349.289610928 1.0 1.3302540125278868 1.5265834940642187 22.583898071830195 -10.3499887763995 0.08987317941330246 6.7417866901031925e-18 2.144623534953519 0.9999420110283752 0.0016546029056085942 2.175745128657113 0.0471572675529964 0.8275121902794135 0.3527165450346683 4.466951360760615e-11 10.3499887763995 2.144623534953519 IYVASVHQDLSDDDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYVASVHQDLSDDDIK 16 0 A0A0J9YYL3;Q9UHX1-2;Q9UHX1-6;Q9UHX1-4;A0A0J9YVP6;Q9UHX1;Q9UHX1-5;Q9UHX1-3;A0A0J9YXX5;A0A0J9YXJ8;A0A0J9YVR6;E9PQ56;A0A0J9YWM1;H0YEM1;E9PN18 A0A0J9YYL3 PUF60 Poly(U)-binding-splicing factor PUF60 0 19392800.0 6329800.0 3252000.0 9811000.0 False True 6128863.963757338 4550540.558955968 7241204.776308961 1.0 0.7424770048520103 1.1814921687166469 22.547188252417868 -6.747705607191818 1.6581700060844013 0.8481605528612041 1.1822236801400519 0.6391304438503383 0.10820297607533584 0.3040527600691318 1.644076371921994 0.0515625351818257 0.12549109933264854 1.787698981882256e-07 6.747705607191818 0.3340631272788478 IYVASVHQDLSDDDIK(ub)SVFEAFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYVASVHQDLSDDDIKSVFEAFGK 24 1 A0A0J9YYL3;Q9UHX1-2;Q9UHX1-6;Q9UHX1-4;A0A0J9YVP6;Q9UHX1;Q9UHX1-5;Q9UHX1-3;A0A0J9YXX5;A0A0J9YXJ8;A0A0J9YVR6;E9PQ56;A0A0J9YWM1;H0YEM1 A0A0J9YYL3 PUF60 Poly(U)-binding-splicing factor PUF60 1 35074400.0 4969400.0 13016000.0 17089000.0 True False 7538943.111803681 10693193.10552784 13711351.659625221 1.0 1.4183941896027268 1.8187365863203604 22.845930854856103 -6.9716617346295715 0.2148195218843473 0.8028658795683488 2.445502150275437 0.9999926051575302 0.0009089907430342409 0.0757670767549772 0.00706782075518593 0.011542160229212672 0.041034832712704146 1.0674272003516416e-07 6.9716617346295715 1.642636270707088 IYVDDGLISLQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYVDDGLISLQVK 13 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 45017800.0 21263700.0 17958000.0 5796100.0 False True 27876916.61796369 15278736.399735743 5196375.172117134 1.0 0.5480784194723398 0.18640422982678886 24.732567662075876 -7.951468217371291 0.3304782386619152 1.0969590148417276 6.078991680682828e-20 0.998874433782808 0.011166248973891598 0.10305252035443391 0.06314090739652758 0.05014450052804723 0.08610863144036296 1.1182316562505046e-08 7.951468217371291 -1.0969590148417276 down IYVDDGLISLQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYVDDGLISLQVK 13 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 266680000.0 157990000.0 29912000.0 78778000.0 False True 152974693.92935374 41856017.5890193 58143678.51065814 1.0 0.27361399793582264 0.3800869086066605 27.188717771740794 -10.589889437003723 6.51882357998674 1.0014278189749848 0.32685045327124157 0.9815819780998828 0.04346738376208115 0.000903499331886068 5.684056388543494e-05 0.042156955117505446 0.014029037784478907 2.5710502392471358e-11 10.589889437003723 -0.6745773657037433 IYVDDGLISLQVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYVDDGLISLQVK 13 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 1326130000.0 240270000.0 753240000.0 332620000.0 False True 364507156.0898837 618818436.909018 266877511.2074751 1.0 1.697685289768149 0.7321598677795667 28.44137189725617 -6.712844543641308 1.784663908354061 1.4276852137504608 0.7342024406836661 0.4785985780151558 0.2938773795957544 0.3694831528249303 2.295619647903359 0.13094297363211435 0.3315642138377305 1.937115233152852e-07 6.712844543641308 -0.6934827730667946 IYVDDGLISLQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYVDDGLISLQVK 13 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 47058400.0 21263700.0 6205700.0 19589000.0 False True 29125464.51988593 5931511.654494363 14962481.648118848 1.0 0.2036538044035149 0.5137250819777637 24.795777723598768 -10.495111317555644 6.1729643899242665 1.0004902397604547 0.3586894432103682 0.8508274082685696 0.12658606899163313 0.000854674388278517 6.99040608746643e-05 0.12265413731157863 0.04085547808887149 3.198075279906461e-11 10.495111317555644 -0.6418007965500865 IYVDDGLISLQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYVDDGLISLQVK 13 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 261999700.0 157990000.0 47272700.0 56737000.0 False True 131375685.1437274 47018032.582203746 68600444.37775189 1.0 0.35788991342473425 0.5221700218172164 26.96912304717507 -10.523386177245614 9.526075426494264 1.0000161400754575 0.44002996762196916 0.93936334098966 0.06706707340844895 2.2990250065965763e-05 1.1502376328299002e-06 0.06493927788597376 0.02164580486581607 2.996496831122177e-11 10.523386177245614 -0.5599861724534883 IYVDDGLISLQVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYVDDGLISLQVK 13 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 757985400.0 240270000.0 291690000.0 226025400.0 False True 311034251.4297665 275457195.083883 184891096.4164507 1.0 0.88561691780779 0.5944396656205573 28.21249821934862 -6.955072972532241 0.5000629138397016 1.0058281962429774 0.46166837508192693 0.9995415849843633 0.0036554896776200964 0.08151044070442766 0.028010259366158047 0.004286438612947282 0.0240195310549873 1.108988461304915e-07 6.955072972532241 -0.5441598211610504 IYVDDGLISLQVK(ub)QK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYVDDGLISLQVKQK 15 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 75591000.0 5630600.0 7595600.0 62364800.0 True False 7288922.695719174 7172898.182930986 51015046.31688592 1.0 0.9840820766481266 6.998983038583651 22.797274169007395 -6.906300595230232 0.9205407691626184 0.7912844956513474 7.717850597552832 0.9894494964854121 0.29086061532583823 0.10691600539540617 0.1524058945495826 0.2338588908569934 0.6301641476609962 1.240793200143157e-07 6.906300595230232 6.926566101901485 up IYVISLAEPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYVISLAEPR 10 0 P14868;P14868-2;C9J7S3;C9JLC1;C9JQM9 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 16381800.0 6602900.0 5357900.0 4421000.0 False True 8656465.84257456 4558522.20493062 3963557.3292265264 1.0 0.5266031528144803 0.45787246219268934 23.045346708355854 -13.999999999999998 0.271782537182646 4.689072674501052 0.43544949350601825 0.9995871730851866 0.004896677137809914 14.971082939616599 0.1650464849038593 30.54822090559182 0.028293119173001504 1.0000000000000041e-14 13.999999999999998 -4.253623180995033 IYVISLAEPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYVISLAEPR 10 0 P14868;P14868-2;C9J7S3;C9JLC1;C9JQM9 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 17983200.0 7365200.0 3032500.0 7585500.0 False True 7131395.757506646 4243393.064278588 5598629.989877852 1.0 0.5950298102320165 0.7850679138070026 22.76575303805002 -10.045695296610281 4.8543090654985255 1.000007224423796 0.6900488620152041 0.7800679168992184 0.07758273092233481 20336255.849771176 42084638.02624774 973.9929461993778 0.026558631080822515 9.001288954058788e-11 10.045695296610281 -0.309958362408592 IYVISLAEPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYVISLAEPR 10 0 P14868;P14868-2;C9J7S3;C9JLC1;C9JQM9 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 20901100.0 6602900.0 6065800.0 8232400.0 False True 9044170.56666314 5797792.899081792 6288076.671600057 1.0 0.641053024856971 0.6952629459220881 23.108556769878746 -10.354908527693814 5.7775306359323055 1.000062215074726 0.6681579853895722 0.980377717143365 0.022131107601018378 1.7738789069541456e-05 1.98062952735846e-06 0.021432355359493862 0.00714278426432189 4.416634619386371e-11 10.354908527693814 -0.3319042296851539 IYVISLAEPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYVISLAEPR 10 0 P14868;P14868-2;C9J7S3;C9JLC1;C9JQM9 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 13535600.0 7365200.0 3470100.0 2700300.0 False True 6124490.133683018 3451405.882539083 3264920.2452234593 1.0 0.5635417491420708 0.5330925797834651 22.546158313484295 -13.999999999999998 0.37810286014184086 7.398275040793602 0.5303281318232809 0.9998044431913665 0.00298264691121579 23.797476851145976 0.20034870538223154 123.84041345286485 0.008300404379213238 1.0000000000000041e-14 13.999999999999998 -6.867946908970321 IYVLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYVLLR 6 0 P84090 P84090 ERH Enhancer of rudimentary homolog 0 244555000.0 79838000.0 84986000.0 79731000.0 False True 104668391.15229191 72306420.07283331 71481200.95375696 1.0 0.6908142876451391 0.6829301584444173 26.641250587109592 IYVLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 IYVLLR 6 0 P84090 P84090 ERH Enhancer of rudimentary homolog 0 291649000.0 106530000.0 53129000.0 131990000.0 False True 103148263.46157372 74343686.7640748 97417859.38487615 1.0 0.7207458881920041 0.9444449777011288 26.62014429223348 -9.926668506786616 5.915795350245395 1.0000000748441462 0.8325954334071123 0.427491139987609 0.0913247708706963 9.012825825096086e-08 1.6370763060918205e-08 0.08842486803956678 0.029474943056494604 1.183944905805318e-10 9.926668506786616 -0.16740464143703393 IYVLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 IYVLLR 6 0 P84090 P84090 ERH Enhancer of rudimentary homolog 0 599970000.0 194150000.0 232480000.0 173340000.0 False True 294539744.2662463 190992127.6254696 139079273.02237907 1.0 0.6484426341214724 0.4721918713172363 28.133887079019086 -13.999999999992689 0.0895094429268732 2.804011299990665 0.02732528993061317 0.9998447050654865 0.0027341344088547257 12.168132735088586 0.08680746701410219 4.183969097017037 0.3998807811983602 1.0000000000168352e-14 13.999999999992689 -2.7766860100600517 IYVLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYVLLR 6 0 P84090 P84090 ERH Enhancer of rudimentary homolog 0 334738000.0 79838000.0 113340000.0 141560000.0 False True 109356266.14082485 108332264.03474072 108126443.51971519 1.0 0.9906360911704367 0.9887539812348206 26.704460648632484 -13.999999999999998 0.22555562488553427 1.057921587512975 0.9877993081077591 0.9995026801122646 0.00010952712812911417 13.156910265837878 0.15041165713455654 0.34045133260502264 0.0010047464529544374 1.0000000000000041e-14 13.999999999999998 -0.07012227940521598 IYVLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYVLLR 6 0 P84090 P84090 ERH Enhancer of rudimentary homolog 0 210483000.0 106530000.0 59248000.0 44705000.0 False True 88584415.0791902 58928819.26419285 54052608.807434306 1.0 0.6652278418445652 0.6101819237516428 26.400549567667756 -13.999999999999998 0.2540391935188956 3.3764132970387157 0.5888839433089184 0.9995504259429915 0.003652445301835849 14.16173571696423 0.15948705449076123 17.215135689307 0.024845331313827223 1.0000000000000041e-14 13.999999999999998 -2.7875293537297976 IYVLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 IYVLLR 6 0 P84090 P84090 ERH Enhancer of rudimentary homolog 0 449520000.0 194150000.0 255370000.0 0.0 False True 251331002.26865286 241158435.01172882 0.0 1.0 0.9595252190732508 0.0 27.905013401111535 -7.056940023929861 1.0420803587737455 1.0104806346172432 7.289057506973075e-20 0.9881943969066797 0.050215344663043546 0.08487340339523604 0.17713187297775881 0.04027505238055127 0.07196994261015585 8.771219433247483e-08 7.056940023929861 -1.0104806346172432 down IYWGTATTGKPHVAYFVPMSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYWGTATTGKPHVAYFVPMSK 21 1 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 37835100.0 14854900.0 13260000.0 9720200.0 False True 19474917.75505621 11281659.687075181 8714446.946742294 1.0 0.5792917756556974 0.44747028235740766 24.215113899834908 -13.999999999999998 0.1624596767036059 3.0830633966967964 0.32133690923448877 0.9995301154303761 0.0051075421833166375 12.02696923175058 0.12745250535629918 7.893268093226203 0.11532453409039412 1.0000000000000041e-14 13.999999999999998 -2.7617264874623078 IYWGTATTGKPHVAYFVPMSK ddPTM_RPMI8226_Bortezomib_2h_R1 2 IYWGTATTGKPHVAYFVPMSK 21 1 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 80258400.0 23162600.0 14626700.0 42469100.0 False True 22427315.94156621 20467217.58723283 31345168.664309725 1.0 0.9126021874645915 1.3976335262756698 24.418753635973392 -6.860270870121681 1.1842337494967248 0.9525410389616648 1.4212576382023765 0.9539775322834765 0.04528342171213143 0.14653008432639453 0.39030534546119827 0.02981901319116624 0.06963397161223397 1.3795235852919026e-07 6.860270870121681 0.46871659924071174 IYWGTATTGKPHVAYFVPMSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 IYWGTATTGKPHVAYFVPMSK 21 1 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 56743400.0 14854900.0 21755600.0 20132900.0 False True 20347157.968578063 20794365.655851495 15377923.670090979 1.0 1.0219788772448737 0.7557774748610578 24.2783239613578 -6.886868573376769 1.0407027993061722 1.015395336048124 0.7342363752627102 0.9788181255236682 0.017558260152625706 0.12172174274285356 0.236970286210353 0.012904846619339109 0.031830628400289065 1.2975718840541642e-07 6.886868573376769 -0.2811589607854138 IYWGTATTGKPHVAYFVPMSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 IYWGTATTGKPHVAYFVPMSK 21 1 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 37984300.0 17573000.0 10075000.0 10336300.0 False True 14612728.115897985 10020723.975269081 12497572.540348586 1.0 0.6857531253433086 0.8552525196682332 23.800722210720803 -10.161610360300646 4.885227088866133 1.0000184099876368 0.7705028225050236 0.7096664878599472 0.06919783797039167 96922999.57251199 0.2826237037690257 20071.583584818043 0.023688260491466284 6.892704176633094e-11 10.161610360300646 -0.22951558748261325 IYYYHVITR ddPTM_RPMI8226_Bortezomib_1h_R1 1 IYYYHVITR 9 0 Q9BYW2 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 0 2691000.0 0.0 0.0 2691000.0 False True 0.0 0.0 2412561.1338947224 0.0 K(ub)AAALEAMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAAALEAMK 9 1 P31948;P31948-2;P31948-3;H0YGI8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 4711620.0 1008000.0 3276900.0 426720.0 True False 838196.6619714989 3259246.689286279 515945.17906964244 1.0 3.8884033272338456 0.6155419157314493 19.676929250538183 -6.6737221336228965 1.923943732390577 2.837746739079129 0.6284909653404915 0.2956387514682097 1.225894618959234 0.45269148705219364 3.2339040350995245 0.5122913159205175 1.362222132411707 2.1197169196343166e-07 6.6737221336228965 -2.2092557737386374 K(ub)AAGK(ub)GDVPTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAAGKGDVPTK 11 2 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 2 7971100.0 1320900.0 2970500.0 3679700.0 True False 1731712.691613797 2527312.978918312 3298959.942174809 1.0 1.4594297259339761 1.9050272935867216 20.723768161763648 -6.971499116752531 0.2194458322991578 0.7930667815209161 2.5839645903115818 0.9999918328896191 0.0010559191826161026 0.07581918543532817 0.007264160890357553 0.012395231689181128 0.04521673517789803 1.0678269642326011e-07 6.971499116752531 1.7908978087906657 K(ub)AAGK(ub)GDVPTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAAGKGDVPTK 11 2 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 2 8240400.0 1185300.0 2757400.0 4297700.0 True False 1147673.3003004175 3858444.199651035 3172003.4417636385 1.0 3.3619708663092887 2.763855742686815 20.130280588415456 -10.028567927960431 5.223844902650484 0.9999826273675485 3.0629133045041526 0.9406916082336074 0.24417947674076204 4.9405309634329575e-05 9.188329861869138e-06 0.23642774508149597 0.07880858723881602 9.363367560935301e-11 10.028567927960431 2.0629306771366043 K(ub)AAGK(ub)GDVPTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAAGKGDVPTK 11 2 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 2 5180300.0 1320900.0 1357900.0 2501500.0 True False 1809272.425980304 1297903.4880251847 1910697.2200096613 1.0 0.7173621116355388 1.0560583318315941 20.78697822328654 -6.685299060647197 1.8833194696067794 0.8220242407866301 1.054818606787174 0.3483820375276322 0.11965326579025623 0.4268790515316048 2.9317808959562366 0.05089887622314733 0.13332519997214315 2.063958398612083e-07 6.685299060647197 0.23279436600054404 K(ub)AAGK(ub)GDVPTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAAGKGDVPTK 11 2 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 2 4518180.0 1185300.0 2399300.0 933580.0 True False 985629.467693272 2386374.494676236 1128787.2616137897 1.0 2.421167967168445 1.1452450424961 19.910685863849732 -6.620243241253947 2.115010670380665 1.942763640481395 1.1500341891671715 0.08390223334734503 0.6110986306568136 0.5847339666410326 4.970323007055534 0.23733425796376462 0.6779077597598726 2.3974897480168873e-07 6.620243241253947 -0.7927294513142236 K(ub)AAIISAEGDSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAAIISAEGDSK 12 1 P35232;C9JW96 P35232 PHB Prohibitin 1 4807500.0 1345900.0 1680300.0 1781300.0 True False 1764487.9337141407 1429605.789758099 1596988.1634361483 1.0 0.8102100118921556 0.9050717394675432 20.750818133740314 -10.115053149964092 4.61518110633159 1.0000117272253979 0.8576408756769022 0.7501752556865974 0.038727138123169816 53995225.22662712 0.7607027614321401 6729.059899876578 0.013257329459541861 7.672675836326171e-11 10.115053149964092 -0.1423708515484957 K(ub)AAIISAEGDSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAAIISAEGDSK 12 1 P35232;C9JW96 P35232 PHB Prohibitin 1 5814600.0 1533800.0 1898500.0 2382300.0 True False 1485110.3585596741 2656580.9505467126 1758304.162531937 1.0 1.7888104646466696 1.183955220834375 20.50213871101084 -10.274530945898254 4.9469568652862135 0.9998746529466755 1.4863828427408434 0.46299176994451596 0.24693111926558403 0.0003414607953142699 5.00748804495509e-05 0.23915114628870315 0.07969667604783821 5.314581288086992e-11 10.274530945898254 0.4865081897941679 K(ub)AAIISAEGDSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAAIISAEGDSK 12 1 P35232;C9JW96 P35232 PHB Prohibitin 1 17638700.0 3990800.0 4506800.0 9141100.0 True False 6054335.366560582 3702526.328210877 7334357.578313535 1.0 0.6115495928191786 1.2114224162114962 22.529537161614343 -6.73190673481349 1.7163194773881503 0.7667283834504581 1.2111883524375122 0.5680535253720166 0.1632722988303672 0.33268107847936207 1.9207629240988264 0.07536039877920868 0.18659641540506458 1.8539297139803052e-07 6.73190673481349 0.4444599689870541 K(ub)AAIISAEGDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAAIISAEGDSK 12 1 P35232;C9JW96 P35232 PHB Prohibitin 1 4241700.0 1345900.0 1281300.0 1614500.0 True False 1843515.6015799 1224687.9293075113 1233188.3516712368 1.0 0.6643219771278036 0.6689329618986624 20.814028195263205 -10.010059555425055 5.441457935693146 1.0000013683919777 0.6666274695127858 0.9998565400108856 0.001882426651629081 3.124992150696304e-08 5.685070064777848e-09 0.001822659235737724 0.0006075505891238449 9.771032202024699e-11 10.010059555425055 -0.3333738988791919 K(ub)AAIISAEGDSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAAIISAEGDSK 12 1 P35232;C9JW96 P35232 PHB Prohibitin 1 5264200.0 1533800.0 2655900.0 1074500.0 True False 1275422.658860999 2641592.139545126 1299172.9820733273 1.0 2.0711503917486995 1.0186215314957148 20.282543986445116 -6.642075725211185 2.0366587308244353 1.699350957984001 1.0229865236605897 0.16273289767787225 0.4580730767179848 0.5281494704294628 4.189414623724929 0.1829834111443271 0.5073418490921359 2.2799444976849863e-07 6.642075725211185 -0.6763644343234112 K(ub)AAIISAEGDSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAAIISAEGDSK 12 1 P35232;C9JW96 P35232 PHB Prohibitin 1 14782300.0 3990800.0 3610300.0 7181200.0 True False 5166169.270428746 3409383.6312912405 5874295.285334368 1.0 0.6599442358202661 1.137069843792953 22.300663483706792 -6.715281470854777 1.7759147061887932 0.7920881908858285 1.136157226845333 0.49039096799503257 0.1431846688578741 0.36453831080333304 2.244148458675393 0.06407860149200122 0.16178395380879113 1.9262760686122953e-07 6.715281470854777 0.34406903595950455 K(ub)AALSASEGEEVPQDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAALSASEGEEVPQDK 16 1 O95831-3;O95831;O95831-6;O95831-4 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 1 11137100.0 3627600.0 3376600.0 4132900.0 True False 3512443.823647845 4724893.988736377 3050369.50565766 1.0 1.345187062331247 0.8684464887725099 21.74404372106549 -6.712447366615036 1.786192266701039 1.2116746389555726 0.8694686547175631 0.4768726134996677 0.14540495417124097 0.3701657935991233 2.30358757416688 0.06474093125255555 0.1640038873015562 1.9388876010234434e-07 6.712447366615036 -0.3422059842380095 K(ub)AALSASEGEEVPQDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAALSASEGEEVPQDK 16 1 O95831-3;O95831;O95831-6;O95831-4 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 1 22610100.0 10636000.0 6784400.0 5189700.0 True False 16135589.595754787 5573670.813240856 4163953.5202736873 1.0 0.3454271553056399 0.2580602026076077 23.94374295919355 -13.999999999999998 0.28382524159805966 6.448833820906051 0.23273569723556675 0.9996136712967484 0.006507613207447214 15.608959324133144 0.16882610592188 49.48034645931095 0.03394389762491244 1.0000000000000041e-14 13.999999999999998 -6.216098123670484 K(ub)AALSASEGEEVPQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAALSASEGEEVPQDK 16 1 O95831-3;O95831;O95831-6;O95831-4 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 1 7405600.0 2152100.0 3133800.0 2119700.0 True False 2947789.5283157 2995338.353909218 1619070.5165918358 1.0 1.0161303326227251 0.5492490223740417 21.49120208924729 -6.898898146619429 0.9682209620988934 1.0200024254873692 0.5013262849168421 0.9860097105993613 0.02559451886744576 0.1122204090980033 0.1820353160161226 0.01986673977313923 0.051409206823602054 1.2621235007551978e-07 6.898898146619429 -0.5186761405705271 K(ub)AALSASEGEEVPQDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAALSASEGEEVPQDK 16 1 O95831-3;O95831;O95831-6;O95831-4 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 1 10008700.0 3627600.0 5137000.0 1244100.0 True False 3016510.1299283816 5109325.961385336 1504235.557931528 1.0 1.6937871054013804 0.49866749758511225 21.524448996499768 -6.749312970187114 1.6522935088827713 1.4082884919716199 0.49640225160693013 0.6460495402663275 0.29152508615407935 0.3012438438895094 1.6178792987546748 0.1393874434809702 0.33865194670764304 1.7810947758481156e-07 6.749312970187114 -0.9118862403646897 K(ub)AASLK(ub)SNYNLPMHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAASLKSNYNLPMHK 15 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 2 19807300.0 5245600.0 4593500.0 9968200.0 True False 6877032.398462654 3908167.705322757 8936786.285726255 1.0 0.5682927575266942 1.29951202319827 22.713354711629623 -6.746699746578864 1.6618287081040966 0.7451566884737888 1.3006300419294203 0.6347831781039768 0.18138457208930697 0.305816778000065 1.6605800611410804 0.08625700145964739 0.2101583332116319 1.7918442336335257e-07 6.746699746578864 0.5554733534556315 K(ub)AASLK(ub)SNYNLPMHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAASLKSNYNLPMHK 15 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 2 24884500.0 5245600.0 4527900.0 15111000.0 True False 7185040.077009817 4327842.406237009 11542093.020813912 1.0 0.6023407468644376 1.6064062130628172 22.776564773152515 -6.7992619959295455 1.4590276351551708 0.7803867239973484 1.6199985513243333 0.8299623574910551 0.1702414122572859 0.22181673760219828 0.9323207410968639 0.09179806401409674 0.21357528795853817 1.587588718305602e-07 6.7992619959295455 0.8396118273269849 K(ub)ACADATLSQITNNIDPVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KACADATLSQITNNIDPVGR 20 1 P62873;P62873-2;F6UT28;B1AKQ8 P62873 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 1 108245000.0 28654000.0 55333000.0 24258000.0 True False 37565671.48573071 47077532.086344734 21748014.859166943 1.0 1.2532061913022665 0.5789332121329951 25.162911554856326 -6.804980913151779 1.4354796394319074 1.138834589581196 0.5684383651860958 0.846333123548618 0.10901607732994949 0.21372194892846627 0.8688531502839992 0.0597309535476946 0.13851332019931892 1.5668199289084927e-07 6.804980913151779 -0.5703962243951002 K(ub)ACADATLSQITNNIDPVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KACADATLSQITNNIDPVGR 20 1 P62873;P62873-2;F6UT28;B1AKQ8 P62873 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 1 125648000.0 46484000.0 58562000.0 20602000.0 True False 45008390.864055134 81946111.99679562 15205718.153248101 1.0 1.82068521943627 0.3378418526264573 25.42369065075357 -6.75643129611563 1.6256443261508293 1.4787881711569197 0.33329962926376433 0.6763907232984974 0.345029188797363 0.28892293641754435 1.5039628332428798 0.16752105873678458 0.4040524240285282 1.7521395947065177e-07 6.75643129611563 -1.1454885418931555 K(ub)ACADATLSQITNNIDPVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KACADATLSQITNNIDPVGR 20 1 P62873;P62873-2;F6UT28;B1AKQ8 P62873 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 1 166443000.0 99087000.0 30290000.0 37066000.0 True False 150322223.23002604 24884512.843149804 29739888.85339509 1.0 0.16554114427293315 0.1978409327268033 27.163483068244748 -10.31025505103763 5.580511033303662 1.0001158211864403 0.1816910385017822 0.99883287085488 0.013186333418679724 1.900414558292958e-05 2.348866378197197e-06 0.012769390793408176 0.004255870810667519 4.894912681155953e-11 10.31025505103763 -0.818424782684658 K(ub)ACADATLSQITNNIDPVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KACADATLSQITNNIDPVGR 20 1 P62873;P62873-2;F6UT28;B1AKQ8 P62873 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 1 103788000.0 28654000.0 46488000.0 28646000.0 True False 39248158.14523399 44434006.44474173 21880404.782888997 1.0 1.1321297239049541 0.5574887030857012 25.226121616379217 -6.846210574805877 1.2532539415316921 1.070342127929381 0.5361440818263431 0.9346063106657873 0.06284072249540423 0.16167404690899667 0.49056632141079726 0.03927179609507661 0.0906833606712464 1.4249165319175125e-07 6.846210574805877 -0.5341980461030379 K(ub)ACADATLSQITNNIDPVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KACADATLSQITNNIDPVGR 20 1 P62873;P62873-2;F6UT28;B1AKQ8 P62873 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 1 112246000.0 46484000.0 44483000.0 21279000.0 True False 38653505.59036026 44243361.24981579 25728340.517020322 1.0 1.1446144553794255 0.6656146738586286 25.204095926187847 -6.825745362243513 1.3469006995024424 1.0775265503337812 0.6538174301181735 0.8970771704396865 0.06435605980204491 0.1861206042735525 0.6618438536581059 0.03753190915554439 0.08639867748608729 1.493669929058199e-07 6.825745362243513 -0.4237091202156077 K(ub)ACGDSTLTQITAGLDPVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KACGDSTLTQITAGLDPVGR 20 1 P62879;C9JIS1;C9JXA5;C9JZN1 P62879 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 59905000.0 11019000.0 23592000.0 25294000.0 True False 14446015.708147809 20072165.560895756 22676819.517180678 1.0 1.3894603166999673 1.5697629003954736 23.784168308445775 -11.533946332533766 0.13397675792308922 9.353681175368998e-20 1.8492395550660279 0.9997064396129315 0.004073880829507464 4.382377243185974 0.08718990801518034 1.4850733332842332 0.20429104585959215 2.92451374910703e-12 11.533946332533766 1.8492395550660279 K(ub)ACGDSTLTQITAGLDPVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KACGDSTLTQITAGLDPVGR 20 1 P62879;C9JIS1;C9JXA5;C9JZN1 P62879 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 78902000.0 21678000.0 15776000.0 41448000.0 True False 20989843.755937256 22075439.070753146 30591525.38665313 1.0 1.0517200283831944 1.4574441688256927 24.32318809175759 -6.9304618025720846 0.7429842323321082 0.993935009702486 1.541727482739484 0.9966284243834117 0.011876869326425397 0.09239834619783291 0.076508358986655 0.01085035650514834 0.03661811962052243 1.1736489036922112e-07 6.9304618025720846 0.547792473036998 K(ub)ACGDSTLTQITAGLDPVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KACGDSTLTQITAGLDPVGR 20 1 P62879;C9JIS1;C9JXA5;C9JZN1 P62879 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 206492000.0 39293000.0 40549000.0 126650000.0 True False 59610353.70308328 33312714.139216986 101617571.98733307 1.0 0.5588410749103461 1.7046966789273894 25.829059597898908 -6.802338269170594 1.446394354729276 0.7573075334061331 1.7214327927368112 0.8388891137821952 0.189414017275065 0.2174435058125548 0.897840732827395 0.10301177047190159 0.23922926629579871 1.5763829568821214e-07 6.802338269170594 0.964125259330678 K(ub)ACGDSTLTQITAGLDPVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KACGDSTLTQITAGLDPVGR 20 1 P62879;C9JIS1;C9JXA5;C9JZN1 P62879 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 56062000.0 11019000.0 24313000.0 20730000.0 True False 15093022.077278353 23238771.267660614 15834000.947751466 1.0 1.5397029931232395 1.0490941354673171 23.847378369968666 -10.432048351300947 3.061656659665803 0.994640524130525 1.2943985638581819 0.3243737980056318 0.20029023191403628 39065096.06174957 45432612.291722625 1797561.866661698 0.07808023652302873 3.697870079970837e-11 10.432048351300947 0.2997580397276569 K(ub)ACGDSTLTQITAGLDPVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KACGDSTLTQITAGLDPVGR 20 1 P62879;C9JIS1;C9JXA5;C9JZN1 P62879 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 62170000.0 21678000.0 21664000.0 18828000.0 True False 18026217.49823229 21547291.73203268 22764847.749163922 1.0 1.1953307305953496 1.2628743523923596 24.103593367191866 -13.999999999999602 0.1481334178015198 0.05810367775047128 1.3388044695283805 0.9995725870848953 0.002304407694427033 11.951137056075277 0.12111390173329138 3.242042518152513 0.06831889793955503 1.0000000000009162e-14 13.999999999999602 1.2807007917779092 K(ub)ACGDSTLTQITAGLDPVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KACGDSTLTQITAGLDPVGR 20 1 P62879;C9JIS1;C9JXA5;C9JZN1 P62879 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 126767000.0 39293000.0 35629000.0 51845000.0 True False 50865563.08082503 33646214.82959189 42409741.97462269 1.0 0.661473358235085 0.8337613781495724 25.600185919991358 -10.096163294959263 4.646379786576797 1.0000142722358054 0.7476173681870626 0.7410128414649799 0.07033628962285303 97883074.54481518 0.3812065785737449 16692.73044392901 0.024077982769667515 8.013766886658524e-11 10.096163294959263 -0.2523969040487428 K(ub)ACGNFGIPCELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KACGNFGIPCELR 13 1 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 19249100.0 2566800.0 3590300.0 13092000.0 True False 3894023.2582158158 2949582.9138580672 10504360.461572548 1.0 0.7574641234191094 2.6975597640332256 21.89283007033472 -6.875562870438389 1.1041933780081847 0.8569187113370877 2.8238978617918296 0.9699291543999686 0.14967004497647146 0.13163567284379044 0.296625010958536 0.10479468819290948 0.2508091102372821 1.3317942317857874e-07 6.875562870438389 1.9669791504547418 up K(ub)ACGNFGIPCELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KACGNFGIPCELR 13 1 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 13762000.0 2566800.0 4655900.0 6539300.0 True False 3322773.199192263 4396795.072134968 5349214.49888418 1.0 1.3232305693340098 1.6098644650752951 21.66395639242717 -6.972542919943346 0.1877592850743318 0.7999546313835622 2.140952680416917 0.9999960217097238 0.0004968635171856113 0.07548589676442277 0.005974180688424957 0.010315511226831562 0.03144287714407746 1.0652635818512045e-07 6.972542919943346 1.3409980490333548 K(ub)ACNDATLVQITSNMDSVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KACNDATLVQITSNMDSVGR 20 1 Q9HAV0;C9JD14 Q9HAV0 GNB4 Guanine nucleotide-binding protein subunit beta-4 1 23344900.0 6683400.0 7718500.0 8943000.0 True False 6471239.125308207 10800537.301445762 6600560.015750795 1.0 1.6690060577743466 1.0199839455687598 22.625610558013683 -10.228815542259015 4.244440777444805 0.9998209125756773 1.3444950016860218 0.27307192005698155 0.26496216784290605 186788873.34724167 109.33245678419333 335210.87877549196 0.09070359762391338 5.90451809309194e-11 10.228815542259015 0.3446740891103445 K(ub)ACNDATLVQITSNMDSVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KACNDATLVQITSNMDSVGR 20 1 Q9HAV0;C9JD14 Q9HAV0 GNB4 Guanine nucleotide-binding protein subunit beta-4 1 62055200.0 13047000.0 8032200.0 40976000.0 True False 19793252.863464933 6598791.154134962 32877075.639581226 1.0 0.33338588657730117 1.6610243837316332 24.23850539152111 -6.7702249344318615 1.5739481374709596 0.6177537828000775 1.6684946517107315 0.7313002809141562 0.28095651099220786 0.26606175386768155 1.3008807385236756 0.14070953998360972 0.3348294986786046 1.6973643077289623e-07 6.7702249344318615 1.0507408689106539 K(ub)ACNDATLVQITSNMDSVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KACNDATLVQITSNMDSVGR 20 1 Q9HAV0;C9JD14 Q9HAV0 GNB4 Guanine nucleotide-binding protein subunit beta-4 1 18601800.0 6683400.0 5357800.0 6560600.0 True False 5557543.224821751 5328936.46795997 7932391.127212908 1.0 0.9588655008852202 1.427319735775393 22.40601583344796 -6.8855011955220915 1.0486037798868382 0.9720485443303066 1.4642350857698943 0.9778600890239234 0.03151515770660852 0.12287032281874788 0.24376530166022892 0.023024006303729676 0.05654543010830026 1.3016637323656744e-07 6.8855011955220915 0.4921865414395876 K(ub)ACNDATLVQITSNMDSVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KACNDATLVQITSNMDSVGR 20 1 Q9HAV0;C9JD14 Q9HAV0 GNB4 Guanine nucleotide-binding protein subunit beta-4 1 34080200.0 13047000.0 8234200.0 12799000.0 True False 16889598.694819033 7775959.531556467 10469713.328830097 1.0 0.4603993068196333 0.619891183799514 24.009631713613558 -10.814219286704523 10.781041845744078 1.0045678416179227 0.5401452453096051 0.9172470707037721 0.06511228611990905 0.007128228981032026 0.00012283458770805163 0.06286274417344208 0.021014899981324994 1.533842309921782e-11 10.814219286704523 -0.4644225963083176 K(ub)ACQIFVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KACQIFVR 8 1 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 7124000.0 1380200.0 4569500.0 1174300.0 True False 1809455.565875811 3887748.4117714916 1052794.7006810019 1.0 2.1485735737808778 0.5818295406283874 20.787124249746586 -6.710195164076526 1.7943399180243702 1.7059655234766975 0.5854605466912062 0.46611616223170815 0.48398656616243935 0.3746783607746641 2.351630090866879 0.21463095466097923 0.5451690218227706 1.9489685717504752e-07 6.710195164076526 -1.1205049767854913 K(ub)ACQIFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KACQIFVR 8 1 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 6415300.0 3355800.0 1117300.0 1942200.0 True False 3249271.96587205 1563443.716642527 1433479.555248931 1.0 0.4811673916692058 0.44116945897577686 21.631685072423366 -13.999999999999998 0.3634353780209751 7.935610028331451 0.43658774142593204 0.9997794508866994 0.0037800233205298513 22.072292023808824 0.19511187204329447 118.92096168634717 0.011413930291401074 1.0000000000000041e-14 13.999999999999998 -7.499022286905518 K(ub)ADATSSQDSELER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KADATSSQDSELER 14 1 Q99504-4;Q99504-5;Q99504-2;Q99504;Q99504-3;B1APR7 Q99504-4 EYA3 Eyes absent homolog 3;Eyes absent homolog 1 2605870.0 499130.0 944440.0 1162300.0 True False 654364.2635817963 803533.2333982852 1042036.3455688737 1.0 1.227960141038238 1.5924407911047513 19.319734435795453 -6.964174892889941 0.3719462432879691 0.9725823569412142 1.8605443874224208 0.9998951062825646 0.002498923111597593 0.07824213744411772 0.015854404662431428 0.004790387636132091 0.030923098383869453 1.0859882018413116e-07 6.964174892889941 0.8879620304812066 K(ub)ADATSSQDSELER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KADATSSQDSELER 14 1 Q99504-4;Q99504-5;Q99504-2;Q99504;Q99504-3;B1APR7 Q99504-4 EYA3 Eyes absent homolog 3;Eyes absent homolog 1 2200820.0 499130.0 676690.0 1025000.0 True False 683671.849481073 646791.5982854133 782916.1105376385 1.0 0.9460556241658146 1.1451635914684726 19.382944497318345 -6.834535766996984 1.3073626615957554 0.9712517348523482 1.1510411746970972 0.914663816774698 0.024562025414044092 0.1752867492034173 0.5842894825607194 0.014742934083187704 0.03393411964019121 1.463740983922999e-07 6.834535766996984 0.17978943984474904 K(ub)ADATSSQDSELER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KADATSSQDSELER 14 1 Q99504-4;Q99504-5;Q99504-2;Q99504;Q99504-3;B1APR7 Q99504-4 EYA3 Eyes absent homolog 3;Eyes absent homolog 1 16148200.0 2092300.0 2265900.0 11790000.0 True False 2708523.5953989336 2139800.673113818 9644340.975615818 1.0 0.7900247488147322 3.560737293187701 21.36907522827667 -6.888626669204319 1.0305005698421361 0.8461873976525472 3.792705226786542 0.9800035984510066 0.1781119753237142 0.12026334159698908 0.22842703609026216 0.13192946667044483 0.32730899952659437 1.2923297163901696e-07 6.888626669204319 2.946517829133995 up K(ub)AEAGAGSATEFQFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAEAGAGSATEFQFR 15 1 P46783;Q9NQ39 P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 256358200.0 59712200.0 140363000.0 56283000.0 True False 78283272.45376736 119421387.53068884 50459375.06465873 1.0 1.5255032625420313 0.6445741661407818 26.22220073001455 -6.745142399136262 1.6680321605418496 1.3107975822539961 0.6434730463101561 0.6277364889486563 0.22078621598316187 0.30858732400130434 1.6877107908549684 0.10463677717855861 0.25531804647835593 1.7982811869960328e-07 6.745142399136262 -0.66732453594384 K(ub)AEAGAGSATEFQFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAEAGAGSATEFQFR 15 1 P46783;Q9NQ39 P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 271693500.0 106179000.0 100177700.0 65336800.0 True False 102808405.76444618 140179178.0298043 48223132.01801476 1.0 1.3634991904356704 0.4690582609412622 26.61538298529323 -6.796372698927182 1.4705813222050612 1.20149565470415 0.45777814087169666 0.8213476341506754 0.15523955092143923 0.22599195009485945 0.965195416489827 0.08305934904202096 0.19361597615921847 1.598185923146211e-07 6.796372698927182 -0.7437175138324533 down K(ub)AEAGAGSATEFQFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAEAGAGSATEFQFR 15 1 P46783;Q9NQ39 P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 621351600.0 339668000.0 198009000.0 83674600.0 True False 515301189.05705607 162672746.89862192 67136278.63411997 1.0 0.31568478853366316 0.13028551080383088 28.940840680611263 -13.636067515143804 0.1904372180408548 4.176080891352945 8.410778930787721e-22 0.9994671133169941 0.00863415613150382 10.806876381661475 0.1375584195972216 12.800580550154432 0.12612348290310735 2.3117053859916378e-14 13.636067515143804 -4.176080891352945 K(ub)AEAGAGSATEFQFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAEAGAGSATEFQFR 15 1 P46783;Q9NQ39 P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 202702000.0 59712200.0 138935800.0 4054000.0 True False 81789414.00153002 132797156.95674902 3096528.6947508208 1.0 1.6236472479710493 0.03785977357281096 26.28541079153744 -6.800016405628305 1.4557798350525695 1.344087377623797 0.01594350520736768 0.8322302761357511 0.2671771403378501 0.2207332838782373 0.9235390115703896 0.14437905119885808 0.33577896069696056 1.5848333236886426e-07 6.800016405628305 -1.3281438724164292 K(ub)AEAGAGSATEFQFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAEAGAGSATEFQFR 15 1 P46783;Q9NQ39 P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 273761480.0 106179000.0 148446100.0 19136380.0 True False 88292543.02725384 147646391.39505628 23137708.581375875 1.0 1.6722407842469924 0.26205733562611067 26.395788260727507 -6.7770407187043045 1.547173043153468 1.382086136524675 0.2518498672933557 0.7569076350667067 0.2839505488473593 0.2551697203184529 1.2062121910734913 0.14457708681162074 0.3420270625285328 1.6709339430711443e-07 6.7770407187043045 -1.1302362692313195 K(ub)AEAGAGSATEFQFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAEAGAGSATEFQFR 15 1 P46783;Q9NQ39 P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 654201200.0 339668000.0 246680000.0 67853200.0 True False 439706921.85726947 232952041.15085253 55504613.832625516 1.0 0.5297893427897177 0.12623093036193442 28.711967002703712 -7.932099224969478 0.40056837841558957 1.0570060694779109 7.243135738465239e-19 0.9976102507237553 0.01745492395943605 0.10332039338097103 0.08230212638818954 0.04205726639815736 0.08144204776949864 1.1692322214131633e-08 7.932099224969478 -1.0570060694779109 down K(ub)AEGKATSTTELPPEYLTSPLSQQSQLPPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAEGKATSTTELPPEYLTSPLSQQSQLPPK 30 2 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 25007600.0 9723700.0 4605900.0 10678000.0 True False 12747864.864444753 3918717.6736575784 9573142.990608644 1.0 0.3074018837921108 0.7509605014177103 23.603752295026954 -9.934156702623168 6.403812446781455 1.0000000703709193 0.5291811926056528 0.6003608290924085 0.18108204736624436 1.8199370510279057e-07 3.0190783967851294e-08 0.17533196456291963 0.05844397947887229 1.1637060639186851e-10 9.934156702623168 -0.47081887776526654 K(ub)AEGKATSTTELPPEYLTSPLSQQSQLPPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAEGKATSTTELPPEYLTSPLSQQSQLPPK 30 2 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 33201300.0 7901100.0 7210200.0 18090000.0 True False 7650283.905343477 10089270.46069628 13351686.311632775 1.0 1.3188099403277374 1.745253702585737 22.86708185715966 -6.96709124805656 0.32013472880065147 0.9416908795802397 2.136130231529647 0.9999499909315472 0.002159016355144875 0.0772582859958905 0.012394430687621178 0.006460524835462363 0.03750649613595211 1.0787200524154858e-07 6.96709124805656 1.1944393519494074 K(ub)AEGKATSTTELPPEYLTSPLSQQSQLPPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAEGKATSTTELPPEYLTSPLSQQSQLPPK 30 2 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 26667300.0 9723700.0 7980200.0 8963400.0 True False 13318814.663112026 7627608.377007573 6846429.527017635 1.0 0.5726942351809357 0.5140419549481082 23.666962356549845 -13.999999999999998 0.2798135868011084 4.478924776732972 0.4963526103764398 0.9996047648264498 0.004305839324776287 15.388147215624784 0.16756490541122812 30.63187783934484 0.023221756583915853 1.0000000000000041e-14 13.999999999999998 -3.9825721663565323 K(ub)AEGKATSTTELPPEYLTSPLSQQSQLPPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAEGKATSTTELPPEYLTSPLSQQSQLPPK 30 2 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 29052600.0 7901100.0 11817000.0 9334500.0 True False 6570114.728078383 11753339.475509157 11286300.79214843 1.0 1.7889093207580495 1.7178240044903188 22.647487132593938 -10.15979696044719 4.310196005683724 0.9998200038453473 1.7533666626695088 0.9933668783243169 0.029020458994443412 4252812.215962832 5012281.6614878075 5855.8503416507865 0.009934474832450628 6.92154488480594e-11 10.15979696044719 0.7535466588241615 K(ub)AEGKATSTTELPPEYLTSPLSQQSQLPPKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAEGKATSTTELPPEYLTSPLSQQSQLPPKR 31 3 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 37789500.0 8955500.0 14858000.0 13976000.0 True False 13586148.23474824 12206473.813916145 11213637.474101594 1.0 0.8984499214204502 0.8253728194589649 23.695633164447408 -6.974691951809367 0.09285432127349968 1.2037342206390453 0.5182425113346381 0.9999998068059148 3.093971185930641e-05 0.07480715238998044 0.0027133220488759226 0.007268451627663852 0.012652449037946914 1.0600053279682932e-07 6.974691951809367 -0.6854917093044073 K(ub)AEGKATSTTELPPEYLTSPLSQQSQLPPKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAEGKATSTTELPPEYLTSPLSQQSQLPPKR 31 3 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 36582500.0 8955500.0 14748000.0 12879000.0 True False 11593071.289296538 13927260.835466083 10535154.149699416 1.0 1.201343499744077 0.9087457401755256 23.466759486539857 -6.721559110434172 1.7538533918675863 1.122293558203579 0.9091668063045337 0.5197581824771393 0.08471056372099227 0.352317579425033 2.1188178749499165 0.03833935926055802 0.09606469411893213 1.8986324077243646e-07 6.721559110434172 -0.21312675189904517 K(ub)AELLDNEKPAAVVAPITTGYTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAELLDNEKPAAVVAPITTGYTVK 24 2 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 21383000.0 7019100.0 12678000.0 1685900.0 True False 5836692.64885333 12609701.097614016 2038413.8952791304 1.0 2.1604188975226073 0.34924126006182543 22.476719669470032 -6.733630539700379 1.7097102794136751 1.6954751261892322 0.3495231508425393 0.5761618259431123 0.48768867887916084 0.3294613518630518 1.8882376495539834 0.2258849172561225 0.5582894384896907 1.8465856670388996e-07 6.733630539700379 -1.3459519753466929 K(ub)AELLDNEKPAAVVAPITTGYTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAELLDNEKPAAVVAPITTGYTVK 24 2 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 45363000.0 13962000.0 18388000.0 13013000.0 True False 18074084.2321655 17364691.63564891 10644767.524655517 1.0 0.9607508415140545 0.588951970563 24.107419215554838 -6.927095538772228 0.770263322963184 1.0063046074426127 0.5179791302088197 0.9959358690658717 0.011807439778203975 0.09417443184740841 0.08527706231383518 0.010576775491921667 0.03419444834248439 1.1827813315886973e-07 6.927095538772228 -0.48832547723379305 K(ub)AFEEAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAFEEAEK 8 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 18584500.0 5850300.0 8390000.0 4344200.0 True False 7669799.954385787 7138244.703963861 3894703.8565089037 1.0 0.9306950306939923 0.5077973193136299 22.87075751881519 -6.935478790517659 0.7003573566020584 1.0053148287757705 0.40747778620583464 0.9975097724131973 0.010855671178213979 0.08989098383615168 0.06446305808198388 0.010235061978809447 0.03718011311946812 1.1601688735117065e-07 6.935478790517659 -0.5978370425699359 K(ub)AFEEAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAFEEAEK 8 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 15589100.0 5889700.0 5890300.0 3809100.0 True False 5702734.697358782 8242327.5075087175 2811382.439449438 1.0 1.4453289421522881 0.4929884675770605 22.443222486529805 -6.7795441477271625 1.5375368008414743 1.2523096821035153 0.4855399768125102 0.7657860287189235 0.1882896525992581 0.251297126504236 1.173359429252836 0.09645402770447163 0.22768832712612475 1.6613297885330546e-07 6.7795441477271625 -0.7667697052910052 down K(ub)AFEEAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAFEEAEK 8 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 13222800.0 5889700.0 5928300.0 1404800.0 True False 4897546.507949937 5896363.0712245805 1698537.1849386785 1.0 1.203942231411854 0.3468138959337149 22.22362776196408 -6.843929248258296 1.2640000190028848 1.1085009526871763 0.3163529305178276 0.9310051679083223 0.09602940228832553 0.1642582931676874 0.5080721117346193 0.05953002168228878 0.13732684888574162 1.4324212387399806e-07 6.843929248258296 -0.7921480221693487 down K(ub)AFQATLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAFQATLR 8 1 Q6PJG6 Q6PJG6 BRAT1 BRCA1-associated ATM activator 1 1 21523700.0 1470600.0 6514100.0 13539000.0 True False 2231007.715261096 5351607.9601044 10863010.715645505 1.0 2.3987402300301315 4.869104952590538 21.089264072036517 -6.962401827092585 0.4001467219969422 0.864420488587426 6.493648631826881 0.999849169455788 0.019645465438918236 0.07885403688397756 0.018041092702602457 0.03178562826883059 0.20696479489280728 1.0904309580515493e-07 6.962401827092585 5.629228143239455 K(ub)AFQATLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAFQATLR 8 1 Q6PJG6 Q6PJG6 BRAT1 BRCA1-associated ATM activator 1 1 16822200.0 1470600.0 5211600.0 10140000.0 True False 1903720.6898598038 4921569.878635409 8294624.04518612 1.0 2.5852373748156565 4.357059357167024 20.860390394128967 -6.969685526044972 0.26558958957671047 0.5353098656116274 6.459941670163529 0.9999798251212442 0.0061590276420517755 0.07640486397836505 0.009394642015706427 0.03569415434369655 0.1658116299751193 1.0722954766051098e-07 6.969685526044972 5.924631804551901 K(ub)AGNFYVPAEPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAGNFYVPAEPK 12 1 P18124;A8MUD9;C9JIJ5;C9JZ88 P18124 RPL7 60S ribosomal protein L7 1 17631400.0 5209700.0 6363300.0 6058400.0 True False 4332096.378842181 6329019.63988385 7325183.429123363 1.0 1.4609600263730462 1.690909617085004 22.046633909161212 -10.7826358238576 0.13411102117965315 3.0483784676505264e-19 2.070980553103089 0.9997509443309252 0.004533548943130931 2.85090247203916 0.07603363218082726 1.1517063214219037 0.2505670034512507 1.6495450320470344e-11 10.7826358238576 2.070980553103089 K(ub)AGYQDMPEYENFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAGYQDMPEYENFK 14 1 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 31290900.0 2842700.0 6028200.0 22420000.0 True False 3679931.1879943353 5692725.370786318 18339790.04862649 1.0 1.5469651686310502 4.9837317905452965 21.811247358522902 -6.934865981621181 0.7057047592708859 0.9559617558597355 5.785492529034843 0.9974112016342644 0.08971329198545201 0.0901886403594931 0.06587091423265505 0.0842440158241722 0.30308067897566116 1.1618070790892137e-07 6.934865981621181 4.829530773175108 up K(ub)AHLTNQYMQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAHLTNQYMQR 11 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 4415140.0 630240.0 2718500.0 1066400.0 True False 826250.7432528421 2312910.396630004 956059.1576311149 1.0 2.79928389235013 1.1571053526284696 19.65622013883228 -6.6244387195556325 2.101034383828584 2.190165840939904 1.1635898592703036 0.09777869700822217 0.7728882266772296 0.5735602461822518 4.817431357405465 0.3016677926192848 0.8563598562949138 2.3744404408070982e-07 6.6244387195556325 -1.0265759816696003 K(ub)AHLTNQYMQR ddPTM_RPMI8226_Bortezomib_2h_R1 2 KAHLTNQYMQR 11 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 20839800.0 5509200.0 8558600.0 6772000.0 True False 5334313.461583619 11976093.612509398 4998210.044354734 1.0 2.2451049603211746 0.936992188470097 22.346871174150152 -6.657343307161473 1.9821849311565012 1.8032041206064287 0.942455934364435 0.22440465883279614 0.5304757768266484 0.490790169185355 3.7040554347919628 0.216421544004124 0.5879493685763271 2.2011857511087704e-07 6.657343307161473 -0.8607481862419937 K(ub)AHLTNQYMQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAHLTNQYMQR 11 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 23454200.0 4455300.0 10883000.0 8115900.0 True False 6759015.826059265 8940843.620732887 6511788.80767466 1.0 1.3228025870662448 0.9634226306392973 22.688381761655435 -6.6700003717364496 1.9374670044364963 1.2060462545892108 0.964878939139558 0.27898648947858906 0.13712001577348001 0.46112970459936525 3.337197261620159 0.05697728838914697 0.15222367477679813 2.1379602595040871e-07 6.6700003717364496 -0.24116731544965275 K(ub)AHLTNQYMQR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 KAHLTNQYMQR 11 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 15648240.0 4069640.0 6702200.0 4876400.0 True False 5574295.885885745 6406074.642788431 3724694.7526104786 1.0 1.149216829162006 0.6681910736101213 22.410358152636103 -6.823352965229374 1.3570765111993717 1.0801654725624539 0.6568938093058828 0.8919866695114672 0.0660720968413063 0.18914485179993687 0.6834986509529197 0.03824857346184677 0.08809798775166985 1.5019208101026747e-07 6.823352965229374 -0.42327166325657106 K(ub)AHLTNQYMQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAHLTNQYMQR 11 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 15203900.0 3702000.0 8998700.0 2503200.0 True False 3078377.0264072353 8950222.216997897 3026607.5465108915 1.0 2.9074483535383173 0.9831828656944066 21.553738506908843 -6.648170263372602 2.014907061023736 2.2395147896657153 0.9912358166590847 0.18674657521030225 0.8144835434547584 0.5130130248611819 3.9899971734592308 0.3280578954946777 0.9021626400088782 2.2481730460077584e-07 6.648170263372602 -1.2482789730066306 K(ub)AHLTNQYMQR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 KAHLTNQYMQR 11 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 31660160.0 6753560.0 18566400.0 6340200.0 True False 8742616.552570086 17533163.51882273 5186348.6559456615 1.0 2.0054823877261856 0.5932261382801948 23.059633693726607 -6.715510960827965 1.7754508798287323 1.6146316663245315 0.5959579197319242 0.491285672604721 0.4233590885560869 0.3641008031992523 2.240492063703859 0.18951778124331448 0.4782939767199258 1.9252584543313547e-07 6.715510960827965 -1.0186737465926072 K(ub)AIVICPTDEDLKDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAIVICPTDEDLKDR 15 2 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;Q9BUJ2-3 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 1 4213760.0 1819300.0 1612100.0 782360.0 True False 2385119.918126261 1371580.963916584 701408.8921270445 1.0 0.5750574440693496 0.29407699243821167 21.1856303726354 -8.310591990741498 0.21753397127779428 1.2593450124616625 1.0025631046960008e-13 0.9996696278199992 0.005274397356640518 0.09835944744897239 0.04943522804920442 0.11441627822415172 0.11417171166824834 4.891116522381339e-09 8.310591990741498 -1.2593450124615622 down K(ub)ALAAAGYDVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KALAAAGYDVEK 12 1 P10412;Q02539;P22492;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1T;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1t;Histone H1.3;Histone H1.2 1 16909200.0 6116300.0 7033100.0 3759800.0 True False 8018528.530333456 5983788.8948090775 3370771.962548262 1.0 0.7462452583629129 0.4203728838523053 22.93490608321603 -6.967709714919955 0.30801928922673083 1.051392188264721 0.10489702594611633 0.9999586045005742 0.0015263852556520708 0.07705307638774052 0.01167651108162369 0.005202770527441037 0.028987330371718373 1.0771849700609383e-07 6.967709714919955 -0.9464951623186046 down K(ub)ALAAAGYDVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KALAAAGYDVEK 12 1 P10412;Q02539;P22492;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1T;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1t;Histone H1.3;Histone H1.2 1 33521100.0 9184100.0 13357000.0 10980000.0 True False 8892555.772622162 18690519.755834825 8104008.607060685 1.0 2.1018164219310282 0.9113250244671833 23.08416668698162 -6.663538060161734 1.9600719759678882 1.7071655213022214 0.9162345443748061 0.25072301270276753 0.4687384023347877 0.47620359243963506 3.5205127855664604 0.19294771360897603 0.5199304717902697 2.1700110224976024e-07 6.663538060161734 -0.7909309769274153 K(ub)ALAAAGYDVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KALAAAGYDVEK 12 1 P10412;Q02539;P22492;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1T;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1t;Histone H1.3;Histone H1.2 1 21677900.0 9451600.0 5406800.0 6819500.0 True False 14338768.204516375 4441914.296478787 5471622.835906972 1.0 0.30978353461908176 0.38159643547229805 23.773417756482456 -10.354166096911932 5.812939855475474 1.0001152364663408 0.3456899850557417 0.9910464942909819 0.02931749400658197 4.379151160389927e-05 4.865328115719122e-06 0.028391472832304684 0.00946218050333484 4.424191357979503e-11 10.354166096911932 -0.654425251410599 K(ub)ALAAAGYDVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KALAAAGYDVEK 12 1 P10412;Q02539;P22492;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1T;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1t;Histone H1.3;Histone H1.2 1 15643900.0 6116300.0 6379500.0 3148100.0 True False 8377661.396792586 6097632.5958146155 2404583.617154673 1.0 0.7278442404164381 0.2870232518677916 22.998116144738923 -7.031371750967702 0.39005859064450926 1.028311130141813 1.1266836443564345e-14 0.9998770007414706 0.0032580948203608556 0.07312644007055831 0.01702893685918286 0.005781728994414228 0.03476264307105895 9.303111991009265e-08 7.031371750967702 -1.0283111301418018 down K(ub)ALAAAGYDVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KALAAAGYDVEK 12 1 P10412;Q02539;P22492;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1T;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1t;Histone H1.3;Histone H1.2 1 32833800.0 9184100.0 21459000.0 2190700.0 True False 7636986.074615513 21343396.10772202 2648765.241347644 1.0 2.7947407392380983 0.34683384459110683 22.864571962415898 -6.71019954966247 1.7944402592987512 2.103156516314457 0.3525496498621704 0.4660209841156452 0.7562730914254572 0.3747036950221577 2.352080449223023 0.33536856759371825 0.851804686320845 1.948948890805006e-07 6.71019954966247 -1.7506068664522867 K(ub)ALELDPDNETYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KALELDPDNETYK 13 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 16906500.0 3845600.0 4580500.0 8480400.0 True False 5041618.840843377 3897107.25464916 7602929.557740923 1.0 0.7729872839806431 1.5080333912091384 22.265455620243493 -6.823773928729717 1.3555114216579724 0.8780874701543983 1.5254109178894246 0.892836146131023 0.10059892291464348 0.18862179570020607 0.6799541974217503 0.05830453701724224 0.13426361521650118 1.500465697169868e-07 6.823773928729717 0.6473234477350264 K(ub)ALELDPDNETYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KALELDPDNETYK 13 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 71092500.0 12232000.0 29118800.0 29741700.0 True False 18556838.27898388 23922322.63377717 23863239.95874978 1.0 1.289137851724981 1.285953975563582 24.145447588696687 -10.044257265267454 5.297410626786838 0.9999975126027979 1.2875459136447784 0.9999080550599156 0.0012998120016790458 3.8184799977629823e-08 6.889266721399574e-09 0.0012585484342050714 0.0004195125193909605 9.031143327296459e-11 10.044257265267454 0.28754840104198054 K(ub)ALELDPDNETYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KALELDPDNETYK 13 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 65952100.0 12232000.0 29448700.0 24271400.0 True False 15834565.128767233 27809853.957512222 19854254.24559473 1.0 1.7562751948892517 1.2538553527766152 23.916573910789136 -10.234161052546067 4.0520962041127335 0.9996037603652558 1.5050652738847516 0.5739988146643066 0.2051120418233377 145815906.57671386 175591411.12089324 659522.3582879727 0.07506332698421854 5.832287812425196e-11 10.234161052546067 0.5054615135194959 K(ub)ALWFQGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KALWFQGR 8 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4 P43243 MATR3 Matrin-3 1 9638100.0 1882400.0 3010200.0 4745500.0 True False 2436803.9076513625 2842679.7238215324 3881867.6929418896 1.0 1.1665607211543585 1.593016032497792 21.216558729765268 -6.954948302101674 0.5015875440241525 0.9915756985191395 1.7864441721874178 0.9995345649210746 0.0053876050931587986 0.08155750918832817 0.02819433797205549 0.006299566439399202 0.03518073540448811 1.1093068579714661e-07 6.954948302101674 0.7948684736682783 K(ub)AMFANQLDAR ddPTM_RPMI8226_Bortezomib_1h_R1 2 KAMFANQLDAR 11 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 634117100.0 245343900.0 183569200.0 205204000.0 True False 321648228.81370723 156181390.90713722 183971458.53576118 1.0 0.48556583533247005 0.5719647803262553 28.260908503469082 -10.795194096097166 7.1894279028673695 1.015878152742898 0.5287653078293627 0.9754082150919645 0.03527222159159417 0.008679796255997699 0.00024726182501896404 0.033021666795046346 0.011384060567331817 1.6025290238953467e-11 10.795194096097166 -0.48711284491353524 K(ub)AMFANQLDAR ddPTM_RPMI8226_Bortezomib_2h_R1 2 KAMFANQLDAR 11 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 376248080.0 140082000.0 103411780.0 132754300.0 True False 135635173.58701023 144704643.0393084 97981966.28636773 1.0 1.0668666483217208 0.7223934890569672 27.015156112936648 -6.856357474649389 1.2039368067732976 1.035985039900854 0.706831112467399 0.9490639272186678 0.03366058349085165 0.15060251393496157 0.4168789635440288 0.021835840025296906 0.050782364522534075 1.3920105453866543e-07 6.856357474649389 -0.32915392743345506 K(ub)AMFANQLDAR ddPTM_RPMI8226_Bortezomib_8h_R1 2 KAMFANQLDAR 11 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 966707700.0 384839800.0 347089300.0 234778600.0 True False 583830112.1579883 285148502.5939214 188374506.80288407 1.0 0.48841006425642935 0.32265294797248945 29.120973381622296 -13.999999999999998 0.15761826642153892 3.5072432174149335 0.1553462273271775 0.9995428368359516 0.0061640278895169764 11.994638828619927 0.12537663695730772 9.196137747110257 0.15204212697277622 1.0000000000000041e-14 13.999999999999998 -3.3518969900877558 K(ub)AMFANQLDAR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 KAMFANQLDAR 11 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 501547900.0 245343900.0 157672000.0 98532000.0 True False 336054169.9995977 150705529.68842122 75260770.9302386 1.0 0.4484560619753703 0.22395428371065504 28.324118564991974 -11.06363154128635 0.17487105893867416 2.0252418218197596 5.621996094341637e-09 0.9995094500612819 0.0072217401721006306 3.261272916192288 0.10038100251936667 1.5020777984451301 0.16749812534393932 8.637110159468201e-12 11.06363154128635 -2.0252418161977634 K(ub)AMFANQLDAR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 KAMFANQLDAR 11 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 427371400.0 140082000.0 193604800.0 93684600.0 True False 116484389.68481317 192561812.51485586 113273616.71135134 1.0 1.653112601919409 0.9724360235551764 26.795561388370924 -6.655491766416938 1.9883722375073682 1.4219271299845633 0.9752559032433237 0.21691137582504783 0.27837769518215116 0.4951659376287622 3.7582887876962667 0.11328665449030961 0.30856521446384577 2.210590165432421e-07 6.655491766416938 -0.4466712267412396 K(ub)AMFANQLDAR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 KAMFANQLDAR 11 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 879623800.0 384839800.0 353305200.0 141478800.0 True False 498182707.42656696 333643455.0397685 115731110.09507672 1.0 0.6697210683270217 0.23230655815594664 28.892099703714745 -7.309338373831105 0.39058710581359757 1.0349567376577067 2.729925196869427e-11 0.9995146631103083 0.006926898816489808 0.10329239670904296 0.03181655381790109 0.012175112395912584 0.05257663316967013 4.905255418349254e-08 7.309338373831105 -1.0349567376304074 down K(ub)ANAMLDEDEDERVDEAALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KANAMLDEDEDERVDEAALR 20 2 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 27634500.0 3527000.0 9249600.0 14857900.0 True False 4623931.155516587 7869595.734658414 13320547.03504067 1.0 1.701927530921299 2.8807840313860584 22.14068848741921 -6.96331180144375 0.38593716357436975 0.9242396720796994 3.7005546499379873 0.9998739947159736 0.008710895327417489 0.07853867906068841 0.016909977283810895 0.01526095199986144 0.09933885581661539 1.0881485772518658e-07 6.96331180144375 2.776314977858288 K(ub)ANAMLDEDEDERVDEAALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KANAMLDEDEDERVDEAALR 20 2 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 38952300.0 4187800.0 8089100.0 26675400.0 True False 4054860.581285823 11319119.81409924 19688312.495153602 1.0 2.7914942048414084 4.85548444896478 21.95122088027834 -6.969271327673616 0.27503247234300354 0.5172206142996639 7.192229075362578 0.9999761286371203 0.007696673923392672 0.07653985292830993 0.009873313428731057 0.039249003764848384 0.1906660206213315 1.0733186415806954e-07 6.969271327673616 6.675008461062914 K(ub)ANAMLDEDEDERVDEAALR ddPTM_RPMI8226_Bortezomib_8h_R1 2 KANAMLDEDEDERVDEAALR 20 2 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 141105600.0 17629600.0 75713000.0 47763000.0 True False 26745392.096400812 62201423.60163093 38322622.11473339 1.0 2.3256874820691644 1.4328682105913322 24.67278701844286 -10.404059687396975 5.87212475063835 0.9997215865119297 1.879277846330249 0.5639271109985184 0.36449194127401935 0.0013289438553752873 0.00013486950775000212 0.3530244968970655 0.11763926819842359 3.9440309343865875e-11 10.404059687396975 0.8795562598183194 K(ub)ANAMLDEDEDERVDEAALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KANAMLDEDEDERVDEAALR 20 2 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 24406100.0 3527000.0 4003100.0 16876000.0 True False 4831027.213591134 3826229.805518537 12890236.372129949 1.0 0.7920116439738116 2.6682185386714097 22.203898548942103 -6.879389800655001 1.0831585059104458 0.8720928089382354 2.799658236518881 0.9731915594173383 0.13749187327500145 0.12817376262272123 0.2755427577561239 0.0978321644998141 0.2362283579823791 1.320110238432022e-07 6.879389800655001 1.9275654275806455 up K(ub)ANAMLDEDEDERVDEAALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KANAMLDEDEDERVDEAALR 20 2 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 23143000.0 4187800.0 9571400.0 9383800.0 True False 3482341.2509962735 9519836.968425844 11345909.194210995 1.0 2.7337461444085314 3.2581267533631317 21.731626155712615 -9.789894224710253 0.3149410115450116 3.453766313862815e-12 3.4249144198741996 0.9987571645898766 0.034017878416207785 1.1616623139124478 0.13550120720235687 1.2972947222120639 0.17489437552587264 1.6222051480274602e-10 9.789894224710253 3.424914419870746 K(ub)ANAMLDEDEDERVDEAALR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 KANAMLDEDEDERVDEAALR 20 2 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 102962500.0 17629600.0 53521000.0 31811900.0 True False 22821864.731369786 50542509.301259905 26022460.61765841 1.0 2.2146529171118394 1.140242522859635 24.44391334053531 -6.616570810707945 2.128845460550056 1.8078538546987357 1.1442160588452785 0.07156313961588678 0.5227924444786906 0.5946620239888373 5.115941809997235 0.20209681224967996 0.580071945652483 2.417849081105388e-07 6.616570810707945 -0.6636377958534572 K(ub)APLNIPGTPVLEDFPQNDDEKER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAPLNIPGTPVLEDFPQNDDEKER 24 2 E9PHA2;Q15003;C9J470;C9JZP1 E9PHA2 NCAPH Condensin complex subunit 2 1 30515400.0 4569400.0 11399000.0 14547000.0 True False 5915178.376339856 10764635.629473673 11899595.264824713 1.0 1.8198328003989162 2.0117052280996206 22.495990244022916 -10.88397614001373 0.28229401177966396 1.1955344790805478e-23 2.08070125498362 0.9991963158132955 0.012438172270230936 2.7049080882211722 0.14456236683004353 1.866626196169243 0.0746065517545206 1.3062426506728721e-11 10.88397614001373 2.08070125498362 K(ub)AQCPIVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAQCPIVER 9 1 M0R0F0;P46782;M0R0R2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 1 4613790.0 796590.0 1472700.0 2344500.0 True False 1044337.2041885322 1252978.900539637 2101913.630032026 1.0 1.199783839467084 2.012677152170643 19.994156185697797 -6.944483494790715 0.616452294835434 0.9910773285017327 2.2641872337007816 0.9986940425253339 0.015826753061705234 0.08577964221490447 0.04573505875017894 0.015990771676463348 0.06870438128654886 1.1363614838658351e-07 6.944483494790715 1.2731099051990489 up K(ub)AQCPIVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAQCPIVER 9 1 M0R0F0;P46782;M0R0R2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 1 5406300.0 1574100.0 1473100.0 2359100.0 True False 1524131.0571187783 2061316.5121150154 1741180.9385170173 1.0 1.3524535849375932 1.1424089354943994 20.539555532080595 -10.150497692721514 4.103124289923582 0.9999232762435373 1.247431260099998 0.6491505450142339 0.0857503692414371 11902465.812820464 9814961.892174274 7542.212565185245 0.029354631240679448 7.071349574707801e-11 10.150497692721514 0.24750798385646067 K(ub)AQCPIVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAQCPIVER 9 1 M0R0F0;P46782;M0R0R2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 1 4386790.0 796590.0 1003800.0 2586400.0 True False 1091110.8500353151 959448.7968772977 1975545.588580047 1.0 0.8793321016340768 1.8105819298892556 20.05736624722069 -6.874326701290957 1.1110033278224827 0.9296042115382951 1.8697872897154466 0.9688114691018189 0.07302499439052779 0.13277154911613484 0.30369563846152176 0.05086638945009864 0.12141418552291756 1.3355904306038165e-07 6.874326701290957 0.9401830781771515 K(ub)AQCPIVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAQCPIVER 9 1 M0R0F0;P46782;M0R0R2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 1 4649900.0 1574100.0 1348400.0 1727400.0 True False 1308933.894453708 1341135.901563556 2088591.3534048086 1.0 1.0246017062025028 1.5956431125014876 20.31996080751487 -6.915938961694553 0.8543021006661087 0.9854634444387018 1.6796447470486364 0.992976380064872 0.023061478365802537 0.10062099616383334 0.11843177315104966 0.01945368764119719 0.056190980745588356 1.2135593992682664e-07 6.915938961694553 0.6941813026099346 K(ub)AQPAQPADEPAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAQPAQPADEPAEK 14 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 27195600.0 4606200.0 7270400.0 15319000.0 True False 6038772.806504256 6185684.659797241 13733936.830224188 1.0 1.024328097446347 2.2742926866583897 22.525823965587357 -6.911111068770628 0.8881211651190795 0.9626449653075733 2.439735665707377 0.9913344030558217 0.055393283046807296 0.10368833590891083 0.13481109985168802 0.04560177260135388 0.12687418267439352 1.2271253594867825e-07 6.911111068770628 1.4770907003998037 up K(ub)AQPAQPADEPAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAQPAQPADEPAEK 14 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 32124500.0 4606200.0 9549300.0 17969000.0 True False 6309236.617874536 9127380.350687755 13725092.283171555 1.0 1.446669526520722 2.1753966627733297 22.589034027110248 -6.963823736755424 0.3777012115793245 0.9486315274334695 2.6991103589411702 0.9998867997070771 0.005154196223709144 0.07836247639216812 0.01628183531434488 0.009507345356269374 0.06164553656094297 1.0868666510287001e-07 6.963823736755424 1.7504788315077007 K(ub)AQPAQPADEPAEKADEPMEH ddPTM_RPMI8226_Bortezomib_8h_R1 2 KAQPAQPADEPAEKADEPMEH 21 2 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 62599400.0 8511800.0 32891100.0 21196500.0 True False 12913022.895933235 27021426.22566273 17007002.48424401 1.0 2.0925716962968237 1.3170426956805068 23.622323434529036 -10.23495151026226 4.911410805852405 0.9998768117721317 1.7048071959894395 0.5240913021480347 0.31660838870979563 0.00042717727146971524 6.65408299762375e-05 0.3066077282284638 0.10218491806145043 5.821682142406524e-11 10.23495151026226 0.7049303842173078 K(ub)AQPAQPADEPAEKADEPMEH ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAQPAQPADEPAEKADEPMEH 21 2 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 45061200.0 6187400.0 31407800.0 7466000.0 True False 8009711.271888044 29659928.320324898 6107264.607629145 1.0 3.7029959399939116 0.7624824916054114 22.933318807698125 -6.664959528111869 1.9546618837202128 2.7326623039494087 0.7744410608644546 0.2571542690142322 1.1495110770045445 0.472800012923704 3.477395855586328 0.47420646346117395 1.2756155586126807 2.162920076784567e-07 6.664959528111869 -1.958221243084954 K(ub)ARPQLILSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KARPQLILSR 10 2 Q5SY16 Q5SY16 NOL9 Polynucleotide 5-hydroxyl-kinase NOL9 1 2925710.0 685610.0 1066300.0 1173800.0 True False 663845.6858339404 1492079.1506810414 866346.5667548125 1.0 2.247629505653339 1.305042098249814 19.340488393485483 -10.206006929866017 4.723676548371157 0.9998621257479249 1.7763358019550843 0.4749198372594138 0.38480969769729284 270672199.40901023 101.9504514511828 405903.9756980947 0.1317305948579021 6.222903554478007e-11 10.206006929866017 0.7764736762071595 K(ub)ASGPPVSELITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KASGPPVSELITK 13 1 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 1 17260300.0 2220400.0 11432100.0 3607800.0 True False 2910965.902384189 9726475.241976773 3234499.4644613117 1.0 3.341322285503389 1.1111430270660803 21.47306650986718 -6.63471116822193 2.0630036335228783 2.537113065580577 1.120176418206971 0.13489001347486373 1.0030971453587758 0.5467893591068779 4.440627099272188 0.39681389982765486 1.1112267155706606 2.3189363684777172e-07 6.63471116822193 -1.4169366473736063 K(ub)ASGPPVSELITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KASGPPVSELITK 13 1 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 1 27949100.0 13212600.0 14736500.0 0.0 True False 12793173.245211573 20620861.299832296 0.0 1.0 1.6118644611922683 0.0 23.60887082188784 -6.819429352863606 1.4786282114710432 1.334950858765569 1.092850739810928e-18 0.8425853273707435 0.26359216198784585 0.2063883164024198 0.9035661682614344 0.14229737371777706 0.3126680995105009 1.515551319961754e-07 6.819429352863606 -1.334950858765569 K(ub)ASGPPVSELITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KASGPPVSELITK 13 1 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 1 12193200.0 2220400.0 8085100.0 1887700.0 True False 3041341.8840538017 7727873.548149664 1441864.1384018555 1.0 2.5409420718755857 0.4740881470648726 21.536276571390072 -6.707119364702305 1.805548902709522 1.9501293334129781 0.4793692144846496 0.45133719676378303 0.6496474784606988 0.380917209695734 2.4188422887859353 0.2865315555493931 0.7304582682500006 1.962820726550188e-07 6.707119364702305 -1.4707601189283286 K(ub)ASKTAENATSGETLEENEAGD ddPTM_RPMI8226_Bortezomib_1h_R1 1 KASKTAENATSGETLEENEAGD 22 2 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 95840000.0 49520000.0 30548000.0 15772000.0 True False 64921199.55236217 25990357.475171346 14140064.735707028 1.0 0.40033698783105254 0.21780350383548236 25.952186321094587 -13.999999999999805 0.1666260401903852 3.9983428206345755 0.05086535215579657 0.9995205253081381 0.007316266258680714 12.060485249493173 0.1291900700523007 11.685572704601274 0.15351631520380377 1.00000000000045e-14 13.999999999999805 -3.947477468478779 K(ub)ASKTAENATSGETLEENEAGD ddPTM_RPMI8226_Bortezomib_2h_R1 1 KASKTAENATSGETLEENEAGD 22 2 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 172912000.0 65404000.0 65391000.0 42117000.0 True False 63327785.82033964 91501967.30956002 31085294.21708337 1.0 1.4448944665324361 0.49086343086859324 25.916335302407294 -6.779893508248193 1.5361702746922874 1.2519489194116138 0.48331826365590136 0.7670285188302106 0.1881335355034564 0.2507528649502272 1.1687598872449527 0.09645737994276267 0.2276301339016064 1.659993898532602e-07 6.779893508248193 -0.7686306557557124 down K(ub)ASKTAENATSGETLEENEAGD ddPTM_RPMI8226_Bortezomib_8h_R1 1 KASKTAENATSGETLEENEAGD 22 2 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 115022100.0 61410000.0 46958000.0 6654100.0 True False 93163459.67236774 38577978.015471384 5338914.218404367 1.0 0.414089152025272 0.05730695529320159 26.473260879967814 -8.395890797652873 0.42650245531180747 1.0759056122006987 1.1483422364707708e-17 0.9961803291426233 0.024018296976877 0.1559570415699923 0.12797035259830683 0.07967507323545528 0.07756485190725615 4.01891852925715e-09 8.395890797652873 -1.0759056122006987 K(ub)ASKTAENATSGETLEENEAGD ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KASKTAENATSGETLEENEAGD 22 2 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 107165000.0 49520000.0 40998000.0 16647000.0 True False 67828882.22768158 39186572.79774403 12715321.455726901 1.0 0.5777269433131191 0.1874617572650735 26.015396382617478 -7.754146730756104 0.3569793708844565 1.0678460185250154 4.546108488601838e-12 0.9988416090214851 0.011292965552941075 0.118331073873051 0.05742676771367281 0.033558685596522544 0.07858540419512634 1.7613808456464563e-08 7.754146730756104 -1.0678460185204692 down K(ub)ASKTAENATSGETLEENEAGD ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KASKTAENATSGETLEENEAGD 22 2 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 156584100.0 65404000.0 75440500.0 15739600.0 True False 54386323.88847619 75034087.05273326 19030677.588312116 1.0 1.3796499135811617 0.34991660085973353 25.69674057784157 -6.806897862663567 1.427515475160604 1.207678214136527 0.333149623247095 0.8515737331290401 0.16380997324590854 0.2110640038285061 0.848260261836418 0.09024464645528942 0.2090648168838287 1.5599193213740582e-07 6.806897862663567 -0.874528590889432 down K(ub)ASPEAASTPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KASPEAASTPR 11 1 P29590;P29590-4;P29590-2;P29590-5;P29590-9;P29590-3;P29590-8;P29590-11;H3BT57;P29590-14;P29590-10;P29590-12;P29590-13;H3BVD2;H3BT29;H3BUJ5 P29590 PML Protein PML 1 4890600.0 1479100.0 1747100.0 1664400.0 True False 1939114.4236247735 1486439.4901424623 1492183.8540521644 1.0 0.7665558422095954 0.7695182068022758 20.88696650609814 -9.990913597377643 4.757560204254846 1.0000035168184171 0.7680370244979899 0.9998776911903631 0.0012093803158620463 1665481.7455206406 0.4083249529023064 66.95280735461866 0.00041400304442718705 1.0211426192016009e-10 9.990913597377643 -0.2319664923204272 K(ub)ASPEAASTPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KASPEAASTPR 11 1 P29590;P29590-4;P29590-2;P29590-5;P29590-9;P29590-3;P29590-8;P29590-11;H3BT57;P29590-14;P29590-10;P29590-12;P29590-13;H3BVD2;H3BT29;H3BUJ5 P29590 PML Protein PML 1 5313200.0 1944600.0 1677900.0 1690700.0 True False 1882869.7374202255 2347894.2201329074 1247854.9500872043 1.0 1.246976449549731 0.66274098801807 20.844501762755627 -6.791860594154996 1.4889176167802056 1.1377023851528836 0.6562075582956234 0.8072840567244012 0.10512179068832596 0.2325917724859032 1.0185912802638997 0.05556711282406335 0.1299206243684339 1.614876839125689e-07 6.791860594154996 -0.4814948268572602 K(ub)ASPEAASTPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KASPEAASTPR 11 1 P29590;P29590-4;P29590-2;P29590-5;P29590-9;P29590-3;P29590-8;P29590-11;H3BT57;P29590-14;P29590-10;P29590-12;P29590-13;H3BVD2;H3BT29;H3BUJ5 P29590 PML Protein PML 1 4627500.0 1479100.0 1491300.0 1657100.0 True False 2025963.24117455 1425409.434930378 1265727.1090457775 1.0 0.7035712227947426 0.6247532449364548 20.950176567621032 -13.999999999999998 0.185936453590954 2.5673711448894467 0.5658369382732631 0.9994921647003265 0.0036406098855296313 12.287341322715026 0.13673298443714577 6.968585598262313 0.05600854729655294 1.0000000000000041e-14 13.999999999999998 -2.0015342066161836 K(ub)ASPEAASTPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KASPEAASTPR 11 1 P29590;P29590-4;P29590-2;P29590-5;P29590-9;P29590-3;P29590-8;P29590-11;H3BT57;P29590-14;P29590-10;P29590-12;P29590-13;H3BVD2;H3BT29;H3BUJ5 P29590 PML Protein PML 1 4165000.0 1944600.0 1254600.0 965800.0 True False 1617021.0603866854 1247841.220781398 1167744.3146453437 1.0 0.7716913844541989 0.7221577648259546 20.624907038189903 -13.999999999734376 0.2147437110530702 2.346818070724623 0.6942897415465141 0.9994931975232553 0.0027240380582617516 12.861938818845694 0.14684454901155802 7.325972969741187 0.028395687835755707 1.0000000006116218e-14 13.999999999734376 -1.6525283291781088 K(ub)ASSEGGTAAGAGLDSLHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KASSEGGTAAGAGLDSLHK 19 1 A0A1W2PNV4;O15143;C9JEY1;C9K057 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 1 3707900.0 1262500.0 2445400.0 0.0 True False 1049824.6882331537 2432226.144826106 0.0 1.0 2.3167926722313252 0.0 20.00171699956479 -6.755041648300805 1.6474051814776216 1.7718433353996614 1.750914010816208e-07 0.6596477721366383 0.5535093877690964 0.29373201134680305 1.5726570142356602 0.2660022303456132 0.6383172173229382 1.757755039353123e-07 6.755041648300805 -1.7718431603082603 K(ub)ASVEQLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KASVEQLQK 9 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0;H0Y2P2;C9JU75 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 1912100.0 608230.0 890800.0 413070.0 True False 588922.071578269 1246501.0854606302 304874.5751656244 1.0 2.116580691431884 0.5176823723868632 19.167717218194365 -6.718918150943308 1.7630100112220963 1.680072918730538 0.5202857417550999 0.5075546857720677 0.46992193690407974 0.3573942031254999 2.170344259845879 0.21168081708636563 0.5321151626218488 1.910213231868739e-07 6.718918150943308 -1.1597871769754382 K(ub)ATK(ub)HYEMLANR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KATKHYEMLANR 12 2 A0A2R8YFH5;Q15437 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 2 12701900.0 1429500.0 2237400.0 9035000.0 True False 1384121.3049687382 3130805.4878868656 6668462.455809959 1.0 2.261944438430256 4.817830945793132 20.40053895623509 -6.959797653594821 0.4382761107842291 0.9069523262139148 6.272188697210801 0.9997626213197829 0.024469272470735534 0.07977348104149388 0.02139898257249619 0.03362710410860617 0.21184165845961753 1.0969891860937123e-07 6.959797653594821 5.365236370996886 K(ub)ATLELTHNWGTEDDETQSYHNGNSDPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KATLELTHNWGTEDDETQSYHNGNSDPR 28 1 Q04760 Q04760 GLO1 Lactoylglutathione lyase 1 9136400.0 2808600.0 3058700.0 3269100.0 True False 3682101.7985210894 2602353.8827192164 2930844.891421495 1.0 0.7067577229299983 0.7959706308496589 21.812098082538707 -10.330447840032987 8.111807719142778 1.0000009210544851 0.7513641768898287 0.911944281143504 0.03642101714551148 6.066733292198981e-07 5.0042831955759436e-08 0.035264628786277195 0.011754832738041732 4.672530661860622e-11 10.330447840032987 -0.24863674416465642 K(ub)ATLELTHNWGTEDDETQSYHNGNSDPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KATLELTHNWGTEDDETQSYHNGNSDPR 28 1 Q04760 Q04760 GLO1 Lactoylglutathione lyase 1 20697800.0 7986000.0 4095900.0 8615900.0 True False 7732488.801315395 5731414.2298363345 6359137.31854046 1.0 0.7412120957564591 0.822392050210107 22.88250140823704 -10.337289610177477 8.02830542078515 1.0000010432999948 0.7818020729832831 0.9059493972779352 0.033141577625636014 6.188940186500868e-07 5.110301057844098e-08 0.032089348032748946 0.010696398184260719 4.5994975284250275e-11 10.337289610177477 -0.21819897031671176 K(ub)ATLELTHNWGTEDDETQSYHNGNSDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KATLELTHNWGTEDDETQSYHNGNSDPR 28 1 Q04760 Q04760 GLO1 Lactoylglutathione lyase 1 50348300.0 18918300.0 8121900.0 23308100.0 True False 28700444.212990627 6672483.488305665 18701243.81869686 1.0 0.2324871154881119 0.6516011975254429 24.774569730691564 -10.3941225133646 10.070976732145066 1.0000004413892556 0.4420441565163546 0.702651338697309 0.17110260750107162 1.6957953751612812e-06 1.0197290759227511e-07 0.16566951815801934 0.055223129112026224 4.035315416920793e-11 10.3941225133646 -0.5579562848729009 K(ub)ATLELTHNWGTEDDETQSYHNGNSDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KATLELTHNWGTEDDETQSYHNGNSDPR 28 1 Q04760 Q04760 GLO1 Lactoylglutathione lyase 1 14732700.0 2808600.0 8140500.0 3783600.0 True False 3847015.3195611155 7780825.792966369 2889991.6056880136 1.0 2.0225616865632965 0.7512295547649955 21.8753081440616 -6.69260656366006 1.8572481760996553 1.6395036284248163 0.7554859771067483 0.38265963542159287 0.4322440770588451 0.41106159178968565 2.751072241415297 0.18604935186836227 0.4828828804008024 2.0295204714743984e-07 6.69260656366006 -0.8840176513180681 K(ub)ATLELTHNWGTEDDETQSYHNGNSDPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KATLELTHNWGTEDDETQSYHNGNSDPR 28 1 Q04760 Q04760 GLO1 Lactoylglutathione lyase 1 13630600.0 7986000.0 4181700.0 1462900.0 True False 6640712.839786109 4159172.352097543 1768785.6263146333 1.0 0.6263141401294964 0.26635478283557346 22.662906683671316 -7.536639135047661 0.3058452086549578 1.0863775495153905 3.690643682357836e-14 0.9996396307863485 0.00568603357341909 0.12494566058377864 0.03412694538918304 0.02436710542436227 0.06766705875026023 2.9064366743236487e-08 7.536639135047661 -1.0863775495153536 down K(ub)ATLELTHNWGTEDDETQSYHNGNSDPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KATLELTHNWGTEDDETQSYHNGNSDPR 28 1 Q04760 Q04760 GLO1 Lactoylglutathione lyase 1 62228300.0 18918300.0 20777200.0 22532800.0 True False 24490112.285444543 19620930.55537334 18432061.606052246 1.0 0.8011776478066558 0.7526327928274612 24.545696052784013 -13.999999999999329 0.1980293048348004 2.0970461785790846 0.7204862433218748 0.999486952162507 0.0024240317908657935 12.492688409354828 0.1411118297281256 5.304099069990899 0.03137146021808243 1.0000000000015462e-14 13.999999999999329 -1.3765599352572098 K(ub)AVELGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAVELGEK 8 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 5423720.0 2294100.0 2424600.0 705020.0 True False 1907645.7958619208 2411538.1985545834 852436.4223558288 1.0 1.264143586710756 0.4468525678115613 20.86336189161542 -6.819704067510202 1.373138377682498 1.1424163085030858 0.4291215251195082 0.8836991739147014 0.11613410039321656 0.19387058283102326 0.7183534594967296 0.06646270871709704 0.15319924171746727 1.514592955279912e-07 6.819704067510202 -0.7132947833835777 down K(ub)AVELGEK(ub)ASGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAVELGEKASGK 12 2 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 2 4252900.0 1178700.0 1832500.0 1241700.0 True False 1545287.1145470354 1559098.143029054 1113220.795227453 1.0 1.008937516110763 0.7203973842451715 20.55944348528544 -6.899753070281215 0.9628436368774104 1.012077852809389 0.6902633716381401 0.9864426012274099 0.015598057666894278 0.1115867128216678 0.17845371202579455 0.012155914652141954 0.03158806184340825 1.2596414109680526e-07 6.899753070281215 -0.3218144811712489 K(ub)AVELGEK(ub)ASGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAVELGEKASGK 12 2 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 2 4705300.0 1711400.0 1714600.0 1279300.0 True False 1657072.5437729992 2399248.7215208765 944212.9518226533 1.0 1.4478839387791747 0.5698078550458441 20.660205331962377 -6.768065768308638 1.5820687486540805 1.2575293681230237 0.565250195045518 0.7230380747820018 0.18866699830364433 0.2695650284839693 1.3312916753537631 0.09401930935133175 0.22418526220826987 1.7058240443495827e-07 6.768065768308638 -0.6922791730775057 K(ub)AVELGEK(ub)ASGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAVELGEKASGK 12 2 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 2 7421800.0 2552400.0 2161900.0 2707500.0 True False 3872177.4054347994 1776092.0539982023 2172361.4382605916 1.0 0.45868044462667595 0.5610180554257589 21.88471362113035 -9.922798737417788 5.719882925088064 1.000000337959424 0.5098492500258007 0.9683407456239372 0.0417791546608912 1.8005700298303464e-07 3.388128241741163e-08 0.040452520583060404 0.013484164184728538 1.1945415557036103e-10 9.922798737417788 -0.4901510879336233 K(ub)AVELGEK(ub)ASGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAVELGEKASGK 12 2 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 2 3899100.0 1178700.0 1712400.0 1008000.0 True False 1614497.2431697936 1636740.5058504515 769931.1604116487 1.0 1.0137772069755826 0.47688601740813036 20.62265354680833 -6.901010317234602 0.954849316755519 1.021707393423252 0.4193576246882573 0.987062547674261 0.02842536985906636 0.11066573544200131 0.17325127540061916 0.02228393951571744 0.05827909323782364 1.2560001254113664e-07 6.901010317234602 -0.6023497687349946 down K(ub)AVELGEK(ub)ASGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAVELGEKASGK 12 2 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 2 4774210.0 1711400.0 2336200.0 726610.0 True False 1423104.927875025 2323614.4269006057 878540.7915349484 1.0 1.6327780063064066 0.6173408399665808 20.440610607396653 -6.738205050930773 1.6934546305828364 1.3772810565392688 0.616995793792438 0.5968033032432377 0.2658787722839916 0.321060315338616 1.807196091056128 0.12424640586721518 0.30547034332847545 1.8272372874449247e-07 6.738205050930773 -0.7602852627468308 K(ub)AVQLTQAMDTSTVGVLLAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAVQLTQAMDTSTVGVLLAAK 21 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3 D6REX3 SEC31A Protein transport protein Sec31A 1 15728300.0 4570000.0 6379600.0 4778700.0 True False 4424927.851491532 8927007.54917451 3527015.112072946 1.0 2.0174357297521675 0.7970785582151532 22.077222501549425 -6.685469708222631 1.8827222402422024 1.6405587776741952 0.8015334744099456 0.3492497331188572 0.4307075101834115 0.4264607928918238 2.9271932360730517 0.18326693007819211 0.4799462325103111 2.063147565586757e-07 6.685469708222631 -0.8390253032642496 K(ub)AYFLGYMVHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAYFLGYMVHR 11 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 16544700.0 2037600.0 5893500.0 8613600.0 True False 3091188.168513539 4841758.878874334 6911118.184525 1.0 1.5663099801532279 2.2357481355942017 21.559730046722716 -6.968912650035196 0.28295245580981776 0.8576649166537006 2.964875200239604 0.9999726160511657 0.0026430468935905002 0.07665712050199877 0.010287161958073113 0.012158772937923577 0.061220363192067584 1.0742054463371673e-07 6.968912650035196 2.1072102835859035 K(ub)AYFLGYMVHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAYFLGYMVHR 11 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 13239300.0 2037600.0 3092300.0 8109400.0 True False 2637713.3671007324 2920210.786649838 6633572.409470637 1.0 1.1070993623009218 2.514895095202096 21.330856368815166 -6.922121764138417 0.8088381885780904 0.9712492570930139 2.7533739615124473 0.9947502473940129 0.05001370547107628 0.0969392750209873 0.09926374503313501 0.04358337237854464 0.13332204421174446 1.196405045456634e-07 6.922121764138417 1.7821247044194335 up K(ub)AYGQALAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAYGQALAK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 372738000.0 83628000.0 163590000.0 125520000.0 True False 109637117.85470413 139183009.66882545 112532394.4728599 1.0 1.2694880382871503 1.0264078140214588 26.70816106724408 -10.640426799291717 3.179962998224536 0.9893664617254472 1.147947926236133 0.3306204310641342 0.09923708626188994 73349060.65341726 87683436.84511411 6461678.23021384 0.036317047870857065 2.2886174275026267e-11 10.640426799291717 0.15858146451068578 K(ub)AYGQALAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAYGQALAK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 509044820.0 144382200.0 220684200.0 143978420.0 True False 139798866.0918204 308804551.9128997 106266152.54198524 1.0 2.2089202905986074 0.7601360119200771 27.058777418164595 -6.685316386229967 1.8832811827678981 1.7612435560486925 0.7654446902308837 0.3484375884705391 0.5117890277400144 0.4268505810383185 2.9314864977926427 0.21771241412202996 0.570261369460787 2.0638760614646283e-07 6.685316386229967 -0.9957988658178089 K(ub)AYGQALAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAYGQALAK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 139833000.0 51724000.0 30821000.0 57288000.0 True False 78469089.53091584 25320751.74442788 45965001.68977756 1.0 0.32268440854601504 0.5857720787198368 26.225621125061735 -10.335023895755604 5.785283829559122 1.00007761319365 0.45422824363310293 0.8515878092324021 0.1074050915905903 0.00010753454709794269 1.2360364546234896e-05 0.10400920938851671 0.03466484425235221 4.6235558096567916e-11 10.335023895755604 -0.5458493695605471 K(ub)AYGQALAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAYGQALAK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 336758000.0 83628000.0 133150000.0 119980000.0 True False 114547531.56172375 127266992.73183115 91643195.0656644 1.0 1.1110409015078035 0.800045132498404 26.771371128766972 -6.810139445085687 1.4137664727941253 1.0605057750871003 0.7945771519291973 0.8602477640951347 0.04810559131986259 0.20660129205642222 0.8138183632983131 0.02675410130913868 0.061889039265773216 1.5483193982343692e-07 6.810139445085687 -0.265928623157903 K(ub)AYGQALAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAYGQALAK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 439101200.0 144382200.0 243070000.0 51649000.0 True False 120060196.51597346 241760533.66438287 62448567.10200589 1.0 2.013660985739081 0.5201438021442635 26.83918269359887 -6.723906662699019 1.7449974064290112 1.6141020187049775 0.5219019229505325 0.5309972381326531 0.4263608822203252 0.34778485749913157 2.0716103049525554 0.1938389215755197 0.4844345028604165 1.8883971542857367e-07 6.723906662699019 -1.0922000957544449 K(ub)AYGQALAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAYGQALAK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 92048000.0 51724000.0 24165000.0 16159000.0 True False 66957737.63246866 22820196.507257804 13218227.805341467 1.0 0.340814927656576 0.19741150571568564 25.996747447154185 -13.999999999999998 0.21436123546544114 4.882307301756575 0.11643362331227626 0.9994929044632613 0.007869902430443117 12.85235446743894 0.14671690204850854 21.06030185347472 0.08242227169092538 1.0000000000000041e-14 13.999999999999998 -4.765873678444299 K(ub)CDSWWAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KCDSWWAK 8 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 14341000.0 2235700.0 3559600.0 8545700.0 True False 3391720.351563469 2924361.5687182583 6856638.649286626 1.0 0.8622059797383431 2.0215813624274612 21.69358579345751 -6.877233501565787 1.0950539420723817 0.9173459377330527 2.0995265739336695 0.9713872002013425 0.08747338681806568 0.13011165331477562 0.2873019184335602 0.06167668184686531 0.1481634010020765 1.3266809663337753e-07 6.877233501565787 1.1821806362006169 up K(ub)CDSWWAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KCDSWWAK 8 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 14642800.0 2235700.0 2460100.0 9947000.0 True False 2894157.7222355283 2323193.272398298 8136748.064838885 1.0 0.8027182674079693 2.8114390595664682 21.464712115549958 -6.882761441981819 1.0642360969558202 0.8726094828116961 2.961579452323059 0.9758472156177579 0.14049449829106325 0.12521397768213297 0.25772067914124946 0.10142460876314838 0.24709442796334147 1.3099012543547048e-07 6.882761441981819 2.088969969511363 up K(ub)CGAETQHEGLELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KCGAETQHEGLELR 14 1 Q9HCU5;B5MC98 Q9HCU5 PREB Prolactin regulatory element-binding protein 1 9326600.0 1096800.0 1567100.0 6662700.0 True False 1419829.22116023 1479889.507408386 5450156.965075101 1.0 1.0423010636441734 3.8386003639377426 20.437285980320198 -6.910190005057278 0.8944290514735419 0.9139401894620941 4.201460869114884 0.9909933159678938 0.1260576209950268 0.1042928117859759 0.13808269294113096 0.10330207064642186 0.28554124144939147 1.2297306424899528e-07 6.910190005057278 3.28752067965279 up K(ub)CIGKPGGSLDNSEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KCIGKPGGSLDNSEQK 16 2 Q9Y5L4;K7EIT2 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 1 3884500.0 882000.0 1543700.0 1458800.0 True False 1156310.5413001506 1313385.9772954711 1307857.3697977038 1.0 1.1358419130372241 1.1310606650071309 20.14109747255048 -10.002722373694938 4.602190162608828 0.9999966944414119 1.1334512890305475 0.999038201324999 0.0019519363690174015 235086.73412755106 510953.9952671206 4.525143610106715 0.0006681997255709508 9.937511089521519e-11 10.002722373694938 0.13345459458913556 K(ub)CIGKPGGSLDNSEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KCIGKPGGSLDNSEQK 16 2 Q9Y5L4;K7EIT2 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 1 4177300.0 882000.0 1668100.0 1627200.0 True False 1208099.2351537799 1594397.8263309612 1242888.8732359465 1.0 1.3197573344444748 1.0287970036482461 20.204307534073372 -10.378475144473242 3.7433971306702603 0.9991829044252927 1.1742771690530003 0.3235734140492341 0.11878405775700847 84963715.29342161 707.3509941470015 601630.5563043363 0.040662769683052866 4.1833563013668566e-11 10.378475144473242 0.1750942646277076 K(ub)CLEELQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KCLEELQK 8 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 14706600.0 4798800.0 4752800.0 5155000.0 True False 6291273.271645313 4043700.766269301 4621610.050251691 1.0 0.6427475952275366 0.7346064700576952 22.584920598636884 -9.917244080150953 6.519622079276552 1.0000000271676304 0.6886770326426059 0.9387069507055729 0.03750122861338644 1.4812561171884224e-08 2.489717989535556e-09 0.036310411716870376 0.012103469490157627 1.2099179500112866e-10 9.917244080150953 -0.31132299452502443 K(ub)CLEELQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KCLEELQK 8 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 5467600.0 1868800.0 1536000.0 2062800.0 True False 1809475.966929403 2149332.8101341827 1522490.7973264845 1.0 1.1878205897265943 0.84139873927703 20.787140515596647 -6.759472747989869 1.614406746631493 1.1091719152188386 0.8401655685015408 0.688768981351904 0.07899242130951582 0.2838363591085677 1.4578794645128632 0.03860741889548445 0.09282985312633636 1.7399118742087167e-07 6.759472747989869 -0.26900634671729784 K(ub)CLEELQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KCLEELQK 8 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 54430000.0 10806000.0 24372000.0 19252000.0 True False 16393492.024419567 20022626.180694852 15446833.761548629 1.0 1.2213765164169639 0.9422540199817827 23.966619863963317 -6.695375582033132 1.8474903919709242 1.1380868452219441 0.9431566042015955 0.3955800183414879 0.0935275516117477 0.4052350040341502 2.6857174053514954 0.04043868100423504 0.10459038319132581 2.016621615638891e-07 6.695375582033132 -0.19493024102034862 K(ub)CLEELQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KCLEELQK 8 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 14927400.0 4798800.0 4527500.0 5601100.0 True False 6573046.042693835 4327460.0795596335 4278235.538275483 1.0 0.6583644860315185 0.6508756382485542 22.648130660159776 K(ub)CLEELQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KCLEELQK 8 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 7870300.0 1868800.0 2678600.0 3322900.0 True False 1553990.0018773202 2664169.850139527 4017703.0266463114 1.0 1.7144060431026185 2.5854111170552363 20.567545791030923 -6.968472527309694 0.29237815482069446 0.8345804841710239 3.492236749377468 0.9999678954259981 0.0036732817998789357 0.07680153659765857 0.010795030318668753 0.015025359725472335 0.07877184058946948 1.0752946194511202e-07 6.968472527309694 2.657656265206444 K(ub)CLEELQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KCLEELQK 8 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 51822000.0 10806000.0 23185000.0 17831000.0 True False 13988580.018104888 21894734.368747007 14585940.961510226 1.0 1.565186340601368 1.0427034725920856 23.737746186055766 -10.371971065708342 3.388402701657805 0.9977423176362222 1.3039449064276512 0.3109226331889021 0.21330273883494125 76840331.19136971 124534179.46417402 1761793.999704373 0.07806081106927314 4.2464785460184573e-11 10.371971065708342 0.3062025887914289 K(ub)CLEELQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 KCLEELQKR 9 2 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 2 4839530.0 770330.0 1799800.0 2269400.0 True False 1009910.0898863324 1531276.8555654509 2034584.2576219556 1.0 1.516250675085145 2.0146192002606416 19.945795427995332 -6.971555653106805 0.2178506190831406 0.763844709838069 2.7810626826514815 0.9999921063712175 0.0011638122903910163 0.07580107687775257 0.0071961333711855775 0.014034347813214377 0.05074484946578375 1.067687963815385e-07 6.971555653106805 2.0172179728134125 K(ub)CLEELQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 KCLEELQKR 9 2 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 2 26406000.0 2213800.0 14659000.0 9533200.0 True False 3358496.4504590095 12042986.91871024 7648958.841450011 1.0 3.5858269009229744 2.277494990475461 21.679384073475415 -9.175342016307024 12.575175702486453 1.0000097947261763 2.931660945699218 0.7440139007106138 0.5341242658294543 0.0 0.0 0.5171635965771579 0.17238786552571927 6.678177894596373e-10 9.175342016307024 1.9316511509730416 K(ub)CLEELQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KCLEELQKR 9 2 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 2 5609780.0 770330.0 887450.0 3952000.0 True False 1055141.8183855005 848239.5245952943 3018618.993994878 1.0 0.803910441056357 2.8608656593800297 20.009005489518223 -6.883523197418373 1.0599045246546341 0.8717170283477643 3.0168897064538163 0.9764200081528667 0.1423331149394869 0.12455721995541157 0.2537888277836231 0.1030916342336102 0.2517014507147169 1.307605692565497e-07 6.883523197418373 2.145172678106052 up K(ub)CLEEQGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KCLEEQGLK 9 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 1 2529390.0 866590.0 1075100.0 587700.0 True False 1136107.8820694976 914699.2707069761 526890.4416164735 1.0 0.8051165607977204 0.46376796599342907 20.115668405519575 -6.962553640048931 0.3978130816124271 1.0192230192477179 0.23724153324003316 0.9998534957690096 0.002682471930744553 0.07880123908300973 0.01785109442047405 0.0043937995288698415 0.028623090292947337 1.0900498511663308e-07 6.962553640048931 -0.7819814860076847 down K(ub)CLEEQGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KCLEEQGLK 9 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 1 2280250.0 866590.0 715180.0 698480.0 True False 1186991.7417141874 683580.9828160051 533513.4096471517 1.0 0.5758936299159213 0.44946682516651826 20.178878467042466 -13.999999998886068 0.1696237986071275 3.1366821060549595 0.3374961100588998 0.9995144006667378 0.005188481280361079 12.087911934998864 0.13041394098371656 8.498115735279443 0.1034285770390962 1.0000000025649233e-14 13.999999998886068 -2.7991859959960594 K(ub)CLEEQGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KCLEEQGLK 9 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 1 7503000.0 2010100.0 1705200.0 3787700.0 True False 2602114.0749946916 1610304.1210087314 3098377.465083972 1.0 0.6188445527746574 1.1907154628070227 21.311252779581896 -6.727036763266835 1.733910359502947 0.7698719104567369 1.1902036974509862 0.5455443984734294 0.1602692879565194 0.3418142541738072 2.0118260854854233 0.0732888630532182 0.1824832749106334 1.8748357954683695e-07 6.727036763266835 0.42033178699424933 K(ub)CLELFSELAEDKENYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KCLELFSELAEDKENYK 17 2 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 7403500.0 2543500.0 0.0 4860000.0 True False 3334553.1312890337 0.0 4357133.820411871 1.0 0.0 1.3066619870373875 21.669062005855587 -6.702192107223195 1.8229087507953337 0.38037441126524557 1.3029571187863522 0.4280192299812511 0.4219466794945034 0.3909947583514139 2.527435123767719 0.18454902784274804 0.47335660181218703 1.9852165759982464e-07 6.702192107223195 0.9225827075211066 K(ub)CLELFSELAEDKENYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KCLELFSELAEDKENYK 17 2 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 28303700.0 7994200.0 8222500.0 12087000.0 True False 12127785.854304546 6755130.632314266 9697999.152079694 1.0 0.5569961997569943 0.7996512527995832 23.531812848751677 -10.095057353345224 5.236486454942269 1.0000058708247652 0.6783237262778868 0.700879951503397 0.09906351057845969 6.789924580505837e-06 1.1731721549442785e-06 0.09591958207632115 0.03197261055706568 8.034200147628257e-11 10.095057353345224 -0.3216821445468784 K(ub)CLELFSELAEDKENYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KCLELFSELAEDKENYK 17 2 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 6787100.0 2543500.0 0.0 4243600.0 True False 3483900.685502986 0.0 3241349.0796853886 1.0 0.0 0.9303792996089442 21.732272067378478 -10.03097427330301 14.039902384285964 1.000000000000049 0.46518964981097255 0.3058319659408747 0.3798257585483177 0.0 0.0 0.36776470932955846 0.12258823644318612 9.311630339851322e-11 10.03097427330301 -0.5348103501890765 K(ub)CLELFSELAEDKENYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KCLELFSELAEDKENYK 17 2 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 7206100.0 2665800.0 0.0 4540300.0 True False 2216730.814963914 0.0 5489655.738024699 1.0 0.0 2.476464756553702 21.080002158882067 -6.797103457582998 1.4677330663793957 0.44620103234988157 2.508240177119069 0.8235321977972361 0.4273190212034226 0.22493138162009516 0.9569098759469397 0.22907371047463299 0.5337030175165697 1.5954990223628785e-07 6.797103457582998 2.0620391447691873 K(ub)CLELFSELAEDKENYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KCLELFSELAEDKENYK 17 2 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 15237000.0 7994200.0 7242800.0 0.0 True False 10348649.489240618 6839731.813067118 0.0 1.0 0.6609298942995716 0.0 23.302939170844127 -7.510217691588442 0.7112596389877851 0.9934091582297121 5.389813017469866e-17 0.9870762081331438 0.04720534264123211 0.11937146668565175 0.14277646209876865 0.04177952804128788 0.07574016264019662 3.0887467995624024e-08 7.510217691588442 -0.9934091582297121 down K(ub)CLELFSELAEDKENYKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KCLELFSELAEDKENYKK 18 3 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 15449400.0 3855200.0 6731900.0 4862300.0 True False 5054204.533809901 5727526.760740671 4359195.838475031 1.0 1.1332202174301826 0.8624890048106211 22.269052617845585 -6.772909258060451 1.5633813559219134 1.0761273309112538 0.8607982170429075 0.7415430758169332 0.05619206187386185 0.2617501488799261 1.2629804617247888 0.02832454474888115 0.067244090367979 1.6869054523442984e-07 6.772909258060451 -0.2153291138683463 K(ub)CLELFSELAEDKENYKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KCLELFSELAEDKENYKK 18 3 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 111488000.0 32795000.0 31437000.0 47256000.0 True False 49752412.63565052 25826821.731597893 37915830.88695943 1.0 0.5191069209192773 0.762090296296315 25.568263151940037 -10.26030657686301 4.854217850380512 1.0000922450994272 0.640598608607363 0.7447063839124255 0.09919754761038001 9.905575010701168e-05 1.5094137520702265e-05 0.09607216014119378 0.03201587082307871 5.491530792325543e-11 10.26030657686301 -0.35949363649206423 K(ub)CLELFSELAEDKENYKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KCLELFSELAEDKENYKK 18 3 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 15995500.0 3855200.0 6656400.0 5483900.0 True False 5280571.622862635 6362298.238228763 4188715.764465715 1.0 1.2048502875489295 0.7932315028794141 22.332262679368476 -6.771372556738625 1.5690210968656046 1.1172899241019112 0.7907852985659106 0.7358451619619694 0.0863675135312138 0.2642165100079941 1.2838556631294984 0.04338163141477171 0.10314433206765514 1.692884946871086e-07 6.771372556738625 -0.32650462553600057 K(ub)CLELFSELAEDKENYKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KCLELFSELAEDKENYKK 18 3 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 105510000.0 32795000.0 35246000.0 37469000.0 True False 42453773.98609566 33284529.116275977 30650026.46440622 1.0 0.7840181447043373 0.7219623507310475 25.339389474032487 -13.999999999999998 0.17489571799603296 2.10386435204394 0.6699805593038536 0.9995051898181256 0.0026507531306567676 12.142952047027274 0.13251583510944462 4.550444096965502 0.04842415798001465 1.0000000000000041e-14 13.999999999999998 -1.4338837927400863 K(ub)CLETLAIQCGHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KCLETLAIQCGHK 13 1 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4;K7ES92 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 1 17728500.0 5355700.0 9359400.0 3013400.0 True False 7021374.564672572 7963014.00265546 2701602.2745738965 1.0 1.1341104123287573 0.38476828855802264 22.74332206189271 -6.860627891592106 1.182648281280071 1.0728797388215126 0.34805908864091245 0.9543944111425351 0.0696743034531774 0.14615065046637105 0.38808395309173765 0.0459403102256323 0.10730886117045504 1.3783899831589142e-07 6.860627891592106 -0.7248206501806 down K(ub)CLETLAIQCGHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KCLETLAIQCGHK 13 1 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4;K7ES92 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 1 9643600.0 5355700.0 4287900.0 0.0 True False 7335847.022350442 4098446.399810883 0.0 1.0 0.5586875499617112 0.0 22.8065321234156 -7.7587532570718825 0.6313336250938731 1.0026707187455262 2.577568906319078e-19 0.9878003359377313 0.0451952955502508 0.11838159951375003 0.1538299675276165 0.04311768171464062 0.07792989744410513 1.7427967561964768e-08 7.7587532570718825 -1.0026707187455262 down K(ub)CPFGALSIVNLPSNLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KCPFGALSIVNLPSNLEK 18 1 P61221;D6R9I9;D6RGF4 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 7849400.0 1691100.0 2409700.0 3748600.0 True False 1637416.956161341 3371905.7764194915 2766729.204410534 1.0 2.059283534185684 1.6896913116721857 20.642990309578998 -10.147478539346242 4.84062548893648 0.9999374636895157 1.8744874228502926 0.8818594114515792 0.15088539303277967 0.00010636451366847895 1.8733126011300744e-05 0.1461049856016977 0.04869805119682915 7.120679859561411e-11 10.147478539346242 0.8745499591607768 K(ub)CSAAALDVLANVYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KCSAAALDVLANVYR 15 1 Q92973-2;Q92973;Q92973-3 Q92973-2 TNPO1 Transportin-1 1 10470900.0 3505400.0 3570100.0 3395400.0 True False 4801441.109873084 3412361.1772580603 2593476.450458049 1.0 0.7106952057042429 0.5401454253234821 22.195036052246937 -10.659302476074899 0.08788800717984233 1.9330765434915096 1.1957265873970647e-11 0.9999400430581428 0.0014697233931223628 2.6921759277892585 0.049505819094736135 0.8458223588397122 0.32423833252352047 2.1912782290840088e-11 10.659302476074899 -1.9330765434795523 K(ub)CYQQIDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KCYQQIDR 8 1 J3KN59;Q12982;Q12982-2;H7C096 J3KN59 BNIP2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 1 2305140.0 562590.0 1167500.0 575050.0 True False 737560.9381293093 993313.5508793565 515549.3422691045 1.0 1.3467545521034745 0.6989921993112904 19.492402725839373 -6.761299784596714 1.6076122143614007 1.2010910402431902 0.6964761936881138 0.6962226672453156 0.14587419527455617 0.28074766284903335 1.4303183185371813 0.0715846989701446 0.17180686392112463 1.7326076012935515e-07 6.761299784596714 -0.5046148465550765 K(ub)CYQQIDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KCYQQIDR 8 1 J3KN59;Q12982;Q12982-2;H7C096 J3KN59 BNIP2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 1 4029130.0 731330.0 1714200.0 1583600.0 True False 1109481.077384672 1408287.6168942687 1270600.7658834641 1.0 1.2693209876223932 1.1452207629161122 20.081453631364646 -10.172443782227482 4.314586628068005 0.9999446499119079 1.2072708752792873 0.7881076083103925 0.05066370461880038 2.715995054645949e-05 5.209399127247633e-06 0.04906809160836971 0.016351640348759564 6.722893287815086e-11 10.172443782227482 0.20732622536737944 K(ub)CYQQIDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KCYQQIDR 8 1 J3KN59;Q12982;Q12982-2;H7C096 J3KN59 BNIP2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 1 2571170.0 562590.0 839080.0 1169500.0 True False 770594.7264230885 802006.6711334948 893288.1866085543 1.0 1.0407632489988776 1.159219179652291 19.555612787362264 -6.952165035404734 0.5345533585010943 0.9981907544949302 1.2072111181025178 0.9993603734142926 0.0017079116512045858 0.08262795504955017 0.03245409306267302 0.0018928848125466342 0.009801735808705947 1.116438911372142e-07 6.952165035404734 0.20902036360758758 K(ub)CYQQIDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KCYQQIDR 8 1 J3KN59;Q12982;Q12982-2;H7C096 J3KN59 BNIP2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 1 1596580.0 647590.0 250910.0 698080.0 True False 538499.7781013129 249558.2980282646 844045.3004427624 1.0 0.4634324992819457 1.5674013895024566 19.038586224717527 -6.774517960309776 1.5569356875246223 0.694022587548052 1.574735069702627 0.7476284097974513 0.22644247821701433 0.2591791909585558 1.2404275657673804 0.11459428480606958 0.2716924699473842 1.68066841999112e-07 6.774517960309776 0.880712482154575 K(ub)DDEENYLDLFSHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDDEENYLDLFSHK 14 1 Q07666;Q07666-2;Q07666-3 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 12825100.0 4311000.0 4628800.0 3885300.0 True False 5651762.747783391 3938201.082921086 3483286.426429268 1.0 0.6968093422650552 0.6163185862314206 22.430269474171453 -13.999999999999998 0.1861572186945711 2.6042948381393454 0.5562866614723918 0.9994919876477406 0.0037234248596603836 12.290680908431298 0.13681541823939042 7.143627430617344 0.05709440479267413 1.0000000000000041e-14 13.999999999999998 -2.0480081766669533 K(ub)DDEENYLDLFSHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDDEENYLDLFSHK 14 1 Q07666;Q07666-2;Q07666-3 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 13251700.0 3816900.0 3934200.0 5500600.0 True False 3695734.5987654254 5505146.576581969 4059827.8455371647 1.0 1.4895946744717503 1.098517151879187 21.817429725755375 -10.206261407497363 6.2841039688465505 0.9999969766187395 1.294055913175469 0.429818995140581 0.15965673003725836 6.76293186969011e-06 8.5411130228759e-07 0.15458855328516224 0.051528988045352685 6.219258272403435e-11 10.206261407497363 0.29405893655672943 K(ub)DDEENYLDLFSHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDDEENYLDLFSHK 14 1 Q07666;Q07666-2;Q07666-3 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 13403000.0 4311000.0 3920800.0 5171200.0 True False 5904893.200394497 3747566.091648244 3949869.0642070617 1.0 0.6346543391162222 0.6689145646094288 22.493479535694345 -10.797998838840495 8.654700175313286 1.0062171111674307 0.6517844518630049 0.9927921821590782 0.013986678488508065 0.0016820188418791412 3.9258351843713563e-05 0.013576061416409737 0.0045141810712291 1.5922129840952846e-11 10.797998838840495 -0.3544326593044258 K(ub)DDEVQVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDDEVQVVR 9 1 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 1 4460700.0 1480600.0 1101500.0 1878600.0 True False 1433599.1634394643 1541334.6942466157 1386538.3032080326 1.0 1.0751503862130294 0.9671729299014628 20.451210269964243 -6.71955403795867 1.7610194662730898 1.04574247830949 0.967346569164128 0.5103750924774519 0.03162527965191553 0.35618067770331163 2.158499008363338 0.01426096035449639 0.035817791215994016 1.9074183748815707e-07 6.71955403795867 -0.07839590914536199 K(ub)DDEVQVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KDDEVQVVR 9 1 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 1 4874300.0 1480600.0 2445600.0 948100.0 True False 1231184.5017013901 2432425.0673864083 1146343.3264808974 1.0 1.9756787581593238 0.9310897959621408 20.23161554539852 -6.661531275643336 1.9669641699334708 1.6272612323152733 0.935403123499613 0.2420953942932207 0.4152757279366945 0.4809865612052772 3.578770333076481 0.17045493170824283 0.4605737707484497 2.180061394781769e-07 6.661531275643336 -0.6918581088156603 K(ub)DEEMGSLQDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDEEMGSLQDR 11 1 Q6ZU80;H0YJE3;Q6ZU80-1;H0YJH2 Q6ZU80 CEP128 Centrosomal protein of 128 kDa 1 4399390.0 622790.0 1563900.0 2212700.0 True False 816483.7211069383 1330572.2160344543 1983751.0297171508 1.0 1.6296371643889562 2.429627166390658 19.6390645963384 -6.967869015270116 0.3048217155718621 0.8689701829167927 3.2155343665840803 0.9999606635131065 0.0036691860811053265 0.0770004224122276 0.01149224429939764 0.012964933565632462 0.07138958460339283 1.0767899282563677e-07 6.967869015270116 2.3465641836672875 K(ub)DEEMGSLQDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDEEMGSLQDR 11 1 Q6ZU80;H0YJE3;Q6ZU80-1;H0YJH2 Q6ZU80 CEP128 Centrosomal protein of 128 kDa 1 5380170.0 2169370.0 3210800.0 0.0 True False 2100504.536803102 4492889.1841008 0.0 1.0 2.138957143572195 0.0 21.002304471176345 -6.766285509461987 1.6163109093603778 1.6596997757022642 3.16963590753849e-09 0.699081068252337 0.4793541420620403 0.2763737174975061 1.4288344378958884 0.23493502297040575 0.5550017202159039 1.712830905418889e-07 6.766285509461987 -1.6596997725326283 K(ub)DEEMGSLQDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDEEMGSLQDR 11 1 Q6ZU80;H0YJE3;Q6ZU80-1;H0YJH2 Q6ZU80 CEP128 Centrosomal protein of 128 kDa 1 2869590.0 622790.0 1128300.0 1118500.0 True False 853052.2932669176 1078447.975210854 854333.3362305854 1.0 1.2642225848555464 1.0015017168042089 19.70227465786129 -10.582955643914921 2.9547829405582067 0.9922283967642971 1.1328621507016075 0.2542868515559368 0.10725534675888358 62354115.19968577 63254736.589742325 3772586.86873536 0.03831382424150457 2.61242815762415e-11 10.582955643914921 0.14063375393731037 K(ub)DEEMGSLQDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KDEEMGSLQDR 11 1 Q6ZU80;H0YJE3;Q6ZU80-1;H0YJH2 Q6ZU80 CEP128 Centrosomal protein of 128 kDa 1 6828330.0 2169370.0 4335800.0 323160.0 True False 1803927.2743860236 4312442.184811087 390731.2618769812 1.0 2.3905853889142232 0.21660034050428595 20.78270974661062 -6.733927166562667 1.7088412283740482 1.8331626686897942 0.2169204372018385 0.5774029587775085 0.5844108666644776 0.3289256542137849 1.883418728781558 0.27081940672617943 0.6690708351023648 1.845324863782509e-07 6.733927166562667 -1.6162422314879556 K(ub)DEGSYSLEEPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDEGSYSLEEPK 12 1 P18827 P18827 SDC1 Syndecan-1 1 4059400.0 1095500.0 2606600.0 357300.0 True False 1500535.9547743362 2491431.793126483 272913.0988244866 1.0 1.6603612763821887 0.18187708062318952 20.517046457506073 -6.785266513174782 1.5150607158367646 1.3713545132481997 0.168108869752242 0.785678263059871 0.27996049601804585 0.24247359226691345 1.0995320434210376 0.14548658549683438 0.34185002673281717 1.6395833025336198e-07 6.785266513174782 -1.2032456434959578 K(ub)DGNASGTTLLEALDCILPPTRPTDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDGNASGTTLLEALDCILPPTRPTDK 26 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 23777700.0 14451000.0 6860900.0 2465800.0 True False 13992260.915077489 9600493.149120836 1819933.007585634 1.0 0.6861287970106201 0.13006711485951128 23.738125760912126 -7.3527292344768815 0.536293334989228 1.0072794866275139 1.5087803720352236e-28 0.9975335028353104 0.01786443682550047 0.10523793343707248 0.06115404645924578 0.018433919263497883 0.06127476989232817 4.438853027020986e-08 7.3527292344768815 -1.0072794866275139 down K(ub)DGNASGTTLLEALDCILPPTRPTDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDGNASGTTLLEALDCILPPTRPTDK 26 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 11577000.0 4543300.0 2722200.0 4311500.0 True False 6223080.788065943 2601924.2028884017 3293212.498129783 1.0 0.4181086975245661 0.5291932742453233 22.569197544745276 -9.98352912140496 6.042137247801372 1.0000003798544805 0.47365098588529786 0.9676741242033492 0.045350088543373517 2.320411571118481e-07 3.898490003761463e-08 0.043910065824936714 0.014636678139760497 1.0386539536525327e-10 9.98352912140496 -0.5263493939691827 K(ub)DGNASGTTLLEALDCILPPTRPTDK(ub)PLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDGNASGTTLLEALDCILPPTRPTDKPLR 29 3 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 12916990.0 5343300.0 2318690.0 5255000.0 True False 7318862.407253046 2216242.608917532 4013877.2301222384 1.0 0.30281244346405795 0.5484291146318664 22.80318799283947 -10.235441056279997 5.497221661714629 1.0000359955433136 0.4256207790482119 0.8793954431136248 0.10027258611380321 4.423884370862771e-05 6.152749919827971e-06 0.09709457861523928 0.032362838008308255 5.815123515135154e-11 10.235441056279997 -0.5744152164951017 K(ub)DGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDGNASGTTLLEALDCILPPTRPTDKPLR 29 3 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 219965300.0 161783000.0 45008000.0 13174300.0 True False 212099079.70880073 38292981.83980995 11811149.812809084 1.0 0.18054289482247593 0.055686945125009886 27.66016312017279 -13.999999999999998 0.264892891404757 7.154995342509067 0.012147229683910049 0.9995724701969683 0.00866022139897705 14.639041642939898 0.16288998361103676 48.3737835061595 0.05321399392090054 1.0000000000000041e-14 13.999999999999998 -7.142848112825157 K(ub)DGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDGNASGTTLLEALDCILPPTRPTDKPLR 29 3 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 448290000.0 224486000.0 132815000.0 90989000.0 True False 217359814.80742383 185848722.1210754 67156251.28851047 1.0 0.8550279741714604 0.3089635098742124 27.695510000582406 -6.946257206605323 0.5985324667467087 1.0061710030770423 0.12993791938585025 0.9988738107370947 0.009984842875722 0.08502453923610334 0.04245827416482438 0.010262742046251631 0.04586798889481772 1.1317299088911573e-07 6.946257206605323 -0.876233083691192 down K(ub)DGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KDGNASGTTLLEALDCILPPTRPTDKPLR 29 3 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 1288630000.0 471430000.0 307770000.0 509430000.0 True False 715193776.1495569 252846038.8820146 408740937.20889926 1.0 0.3535350101105201 0.5715107581185465 29.413758940870075 -10.096353952885448 5.105294238974056 1.0000130912470784 0.4625228841133223 0.8901903416213742 0.08898822649121159 1.3260136757858493e-05 2.3468759321159112e-06 0.08616457629114876 0.028720826600124868 8.010249566240819e-11 10.096353952885448 -0.5374902071337561 K(ub)DGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDGNASGTTLLEALDCILPPTRPTDKPLR 29 3 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 241334000.0 161783000.0 31925000.0 47626000.0 True False 221598547.1211836 30514447.938142765 36377719.68825914 1.0 0.1377014801521041 0.16416046116207425 27.72337318169568 -10.05271810663488 4.993461119081374 1.00001549393756 0.15093097065128236 0.9992722110978105 0.0108018337856911 13760294.369639069 9233966.149161099 2181.8925261912887 0.0036977554338313147 8.856903102277504e-11 10.05271810663488 -0.8490845232862777 K(ub)DGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KDGNASGTTLLEALDCILPPTRPTDKPLR 29 3 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 384780000.0 224486000.0 87527000.0 72767000.0 True False 186670055.41600594 87055474.67825067 87982243.26340605 1.0 0.4663601480389668 0.4713248896151667 27.475915276016682 -10.013887708003196 5.735258019394987 1.000001141736932 0.468842518827642 0.9999344786222811 0.00202684726177422 3.042066009866632e-08 5.236561035509925e-09 0.001962490749765903 0.0006541621407446618 9.685282483716284e-11 10.013887708003196 -0.5311586229092902 K(ub)DGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KDGNASGTTLLEALDCILPPTRPTDKPLR 29 3 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 1081860000.0 471430000.0 315570000.0 294860000.0 True False 610275428.2745867 298008252.09167594 241198505.5190908 1.0 0.48831763214558005 0.3952289316334168 29.184885262962524 -13.999999999999998 0.23967637874791525 4.3815448211532715 0.3539433906797984 0.9995244268159276 0.005798225465432417 13.612013887947812 0.15495070794045002 22.02644718854937 0.04557332234137917 1.0000000000000041e-14 13.999999999999998 -4.027601430473473 K(ub)DLQHPNEFIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KDLQHPNEFIR 11 1 P53618;E9PP73;E9PP63;E9PKQ1 P53618 COPB1 Coatomer subunit beta 1 7584100.0 1813200.0 4003700.0 1767200.0 True False 1507756.1383796846 3982131.273427777 2136713.3493904 1.0 2.6410977027804963 1.4171478364443115 20.52397167803689 -6.57117940988176 2.301122907981885 2.123383108175287 1.4196795168761782 0.0 0.7145216959511792 0.7263104702759243 7.220834626177019 0.26215388051224636 0.8009663392425983 2.68423534146636e-07 6.57117940988176 -0.7037035912991088 K(ub)DLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Bortezomib_1h_R1 2 KDLYANTVLSGGTTMYPGIADR 22 1 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 33789200.0 7243400.0 15643100.0 10902700.0 True False 9496167.545185387 13309210.456326205 9774593.190083237 1.0 1.401534923746586 1.029319790702199 23.178913958650636 -10.681950110757617 7.62744170083208 0.9991920325590804 1.2154273572243919 0.3087404512919757 0.15195619175015035 0.0020952295220620057 8.736701648078773e-05 0.1476531015712827 0.04904365000011946 2.079935604373006e-11 10.681950110757617 0.21623532466531148 K(ub)DLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Bortezomib_2h_R1 2 KDLYANTVLSGGTTMYPGIADR 22 1 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 92265000.0 13216000.0 20809000.0 58240000.0 True False 12796465.31407266 29118142.21750144 42985196.83745126 1.0 2.2754832293789238 3.359146122185721 23.609242023023437 -6.973015123573977 0.17149371956550302 0.06160337061246882 5.602087917762738 0.9999973599595897 0.0015666051918586952 0.07533590042147223 0.005357887969358664 0.045047474930531 0.1249306465365022 1.0641059618809476e-07 6.973015123573977 5.540484547150269 K(ub)DLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Bortezomib_8h_R1 2 KDLYANTVLSGGTTMYPGIADR 22 1 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 550133600.0 34142600.0 50255000.0 465736000.0 True False 51796820.358407155 41286602.605892815 373683075.46065944 1.0 0.7970875880065788 7.2144018276598105 25.626360202394537 -6.899600687226642 0.9638203105930282 0.7302601997589512 7.882496560720044 0.9863656807322403 0.3477850163769059 0.11169874786738745 0.17909593799301446 0.2708427218094556 0.7032612604016693 1.2600834651333297e-07 6.899600687226642 7.152236360961093 up K(ub)DLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 KDLYANTVLSGGTTMYPGIADR 22 1 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 41528900.0 7243400.0 10764800.0 23520700.0 True False 9921480.725524819 10289175.541566772 17965595.084022105 1.0 1.0370604777869488 1.810777602762694 23.242124020173527 -6.916880977084122 0.847524630430327 0.9809355642969199 1.927019562470557 0.9932701166153491 0.030662982683425856 0.10004176291756055 0.11537589336038497 0.025991989574391243 0.07568234875322653 1.210929956016927e-07 6.916880977084122 0.9460839981736372 K(ub)DLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 KDLYANTVLSGGTTMYPGIADR 22 1 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 66989200.0 13216000.0 25198200.0 28575000.0 True False 10989689.568070775 25062452.295148913 34549900.38412788 1.0 2.2805423337857387 3.1438468002325077 23.389647298457714 -8.190018853243442 0.18632250333104652 1.6920357575562322e-09 4.354771116345356 0.9998348229488017 0.011319243765492221 0.08841849720312867 0.03880398221187938 0.3662234196710806 0.40128385834676045 6.456262010198973e-09 8.190018853243442 4.35477111465332 K(ub)DLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 KDLYANTVLSGGTTMYPGIADR 22 1 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 470474600.0 34142600.0 40507000.0 395825000.0 True False 44198268.75126302 38252749.841485225 323788911.50747526 1.0 0.8654807285951014 7.325827926195018 25.397486524486986 -6.902148657447943 0.9476171702331786 0.7470076730818307 8.034253646945524 0.9876044048132493 0.3355909038309212 0.10983987136916128 0.16864794089740698 0.2645050904773087 0.6958949929396422 1.2527123026038944e-07 6.902148657447943 7.287245973863694 up K(ub)DNKVAVGELTDEDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDNKVAVGELTDEDVK 16 2 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 9065300.0 3681600.0 2556500.0 2827200.0 True False 3564729.623205954 3577323.78197138 2086671.505818033 1.0 1.0035329913055508 0.5853659958483405 21.76536122494072 -6.904993333881682 0.929146016479838 1.0150851662455598 0.536733158225921 0.9888913537270678 0.020689369753536524 0.1078229727375024 0.15741057968568245 0.016530071354481205 0.0441933121032419 1.2445337143519304e-07 6.904993333881682 -0.47835200801963873 K(ub)DNKVAVGELTDEDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KDNKVAVGELTDEDVK 16 2 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 9584900.0 3681600.0 4157400.0 1745900.0 True False 3061413.5225340007 4135003.2610207098 2110959.6178704766 1.0 1.350684326238317 0.6895375624143673 21.545766500374995 -6.762560422040797 1.6025253366949592 1.2030388950675663 0.6867832343947851 0.7014949486442251 0.14755904025696256 0.27861265738299645 1.4106806342406986 0.07262751543837578 0.17411841736100872 1.7275856101733732e-07 6.762560422040797 -0.5162556606727813 K(ub)DNKVAVGELTDEDVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KDNKVAVGELTDEDVK 16 2 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 46177000.0 9602900.0 10961000.0 25613100.0 True False 12431143.351458376 10351010.714506635 20951778.61259927 1.0 0.8326676333671507 1.6854265147011824 23.56745565823831 -6.855766667846474 1.2069426557098362 0.9100502650063222 1.7235042969408536 0.94828625616072 0.08389789785284948 0.1512236142737819 0.4210258762796487 0.05430239903010434 0.12621334416614322 1.3939055014217328e-07 6.855766667846474 0.8134540319345314 K(ub)DQEEGVMEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDQEEGVMEK 10 1 Q15043-2;Q15043-3;Q15043;E5RFT1 Q15043-2 SLC39A14 Zinc transporter ZIP14 1 3437640.0 1253000.0 1422700.0 761940.0 True False 1642695.134069262 1210438.7056411637 683101.7578445725 1.0 0.736861442234069 0.41584207786164323 20.64763332631482 -6.968463441689914 0.29256762858596147 1.0608295557095548 0.08192009274672504 0.9999677936141877 0.0013555987796848735 0.07680449795809537 0.010805414870203757 0.00553224462821179 0.029026079315482938 1.0753171152936073e-07 6.968463441689914 -0.9789094629628298 down K(ub)DQEEGVMEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDQEEGVMEK 10 1 Q15043-2;Q15043-3;Q15043;E5RFT1 Q15043-2 SLC39A14 Zinc transporter ZIP14 1 2030560.0 805460.0 540570.0 684530.0 True False 779891.1131865134 756422.4200353094 505231.0575401866 1.0 0.969907731022457 0.6478225600954617 19.572913186319838 -6.925110941545198 0.7858863144993702 1.0058853243823545 0.589242978632577 0.9954869772777085 0.010708292379304598 0.09525711159330362 0.09070753559615517 0.00948555912875585 0.02996466663384296 1.1881986605273081e-07 6.925110941545198 -0.41664234574977743 K(ub)DQEEGVMEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDQEEGVMEK 10 1 Q15043-2;Q15043-3;Q15043;E5RFT1 Q15043-2 SLC39A14 Zinc transporter ZIP14 1 3220600.0 1253000.0 1089500.0 878100.0 True False 1716267.961051799 1041362.287505294 670710.8650371714 1.0 0.6067597316604948 0.390796122900373 20.710843387837713 -9.985640046454556 0.1329287696821394 1.7325961921410344 4.547429596840315e-16 0.9998212163829272 0.0033720549749639006 1.5537712295244253 0.061285249515162135 0.6120938129218811 0.21879439675739884 1.0336177376828573e-10 9.985640046454556 -1.732596192141034 K(ub)DSKYAYTGECR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KDSKYAYTGECR 12 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 30032200.0 5815500.0 5947700.0 18269000.0 True False 8822538.669999257 4886286.4654078 14658124.142412834 1.0 0.5538413203019955 1.6614406227832457 23.07276241780822 -6.797364096712893 1.4666047106694609 0.753004975246208 1.675761709712704 0.8243573642585607 0.19069507538349337 0.22454149439854387 0.9537508555691965 0.10230264557856211 0.23831528074224848 1.594541780826361e-07 6.797364096712893 0.922756734466496 K(ub)DSSSVVEWTQAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDSSSVVEWTQAPK 14 1 Q8TC07-2;Q8TC07-3;Q8TC07;F8WCB5 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 58968000.0 14934000.0 26531000.0 17503000.0 True False 19578618.621061716 22572678.21702803 15691957.460631484 1.0 1.1529249664603738 0.8014844031820941 24.22277564269515 -6.788420301074877 1.502495771497862 1.0856442269435223 0.7978997159882484 0.7962246084641679 0.06494815482107637 0.23770549620943474 1.0601113632100538 0.03402684747530058 0.07976270985038764 1.627719996921661e-07 6.788420301074877 -0.28774451095527387 K(ub)DSSSVVEWTQAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDSSSVVEWTQAPK 14 1 Q8TC07-2;Q8TC07-3;Q8TC07;F8WCB5 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 57536000.0 12972000.0 15760000.0 28804000.0 True False 12560210.960513815 22053050.18731425 21259368.298522387 1.0 1.755786607139288 1.692596435311203 23.5823573600598 -10.167914749196365 4.238197270951944 0.9997851489932171 1.7241915212806584 0.9943221930048038 0.02579727981692297 3675419.85261529 2939262.9935371424 6513.878584382569 0.008831094917128954 6.793369714952101e-11 10.167914749196365 0.7244063722874413 K(ub)DSSSVVEWTQAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KDSSSVVEWTQAPK 14 1 Q8TC07-2;Q8TC07-3;Q8TC07;F8WCB5 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 75930000.0 31340000.0 27187000.0 17403000.0 True False 47545071.26090215 22335267.43699945 13963289.421994131 1.0 0.4697704061570408 0.29368531903908607 25.502792456695826 -13.999999999999998 0.15403776516047926 3.581134572280836 0.10867022217845039 0.9995533266379406 0.006344421096842264 11.975209235019555 0.12379952737097745 9.242465561923918 0.1674533010548412 1.0000000000000041e-14 13.999999999999998 -3.4724643501023857 K(ub)DSSSVVEWTQAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDSSSVVEWTQAPK 14 1 Q8TC07-2;Q8TC07-3;Q8TC07;F8WCB5 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 50477000.0 14934000.0 15242000.0 20301000.0 True False 20455503.376175206 14568558.041446252 15506321.912219118 1.0 0.7122072614656084 0.7580513481902155 24.285985704218042 -10.222462842889936 5.406063477426726 1.000016581304088 0.7351293048279163 0.9780259300804003 0.018715770033302423 3.7405779641632003e-06 5.379749343211712e-07 0.018122600080444036 0.006040488804187222 5.991521983274246e-11 10.222462842889936 -0.2648872764761717 K(ub)DSSSVVEWTQAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KDSSSVVEWTQAPK 14 1 Q8TC07-2;Q8TC07-3;Q8TC07;F8WCB5 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 47706200.0 12972000.0 26922000.0 7812200.0 True False 10786792.757037994 26776965.84240143 9445694.900468368 1.0 2.482384379261428 0.8756722330004341 23.362762635494075 -6.664182496503792 1.9577920945894547 1.9508618974125176 0.8822667557944027 0.25368477462922456 0.6305347927093259 0.47457546811008566 3.500973311129848 0.2597931732005079 0.6994623895396014 2.1667933971534367e-07 6.664182496503792 -1.0685951416181148 K(ub)DTQGFGEESR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KDTQGFGEESR 11 1 E9PP42;E9PNA8;E9PLH2;M0QYU9;M0R0R3;M0R2G5;B7WNH4;Q9BQ49 E9PP42 SMIM7 Small integral membrane protein 7 1 7305400.0 1129500.0 4028800.0 2147100.0 True False 1713534.077510817 3309829.162841928 1722724.7438926403 1.0 1.9315805890770412 1.0053635737406368 20.708543452728968 -6.644834587665314 2.026909356771792 1.6069507367318439 1.009236763620414 0.17341887665915223 0.3981166282625193 0.5212955557788835 4.0988990037411615 0.15962138891043415 0.44091203605139273 2.2655070204869876e-07 6.644834587665314 -0.5977139731114298 K(ub)DTQGFGEESR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KDTQGFGEESR 11 1 E9PP42;E9PNA8;E9PLH2;M0QYU9;M0R0R3;M0R2G5;B7WNH4;Q9BQ49 E9PP42 SMIM7 Small integral membrane protein 7 1 7405100.0 1129500.0 3909800.0 2365800.0 True False 1462160.0157735944 3692216.19300958 1935248.6751579212 1.0 2.525179291718024 1.3235546412709327 20.479669774821417 -6.586298709481569 2.2420075141019855 2.0345844388213683 1.3267822558617255 0.0 0.6615161247211749 0.680471773298978 6.442239654873958 0.24678228434971153 0.7384290841965298 2.592395688657585e-07 6.586298709481569 -0.7078021829596428 K(ub)DVETTSSVSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDVETTSSVSVK 12 1 Q96RL1;Q96RL1-2;D6RC40;D6RCQ3;Q96RL1-5;D6RDZ5;D6R9M3 Q96RL1 UIMC1 BRCA1-A complex subunit RAP80 1 3655000.0 1432700.0 1194000.0 1028300.0 True False 1878283.5742865363 1015859.8541755475 921901.3801501086 1.0 0.5408447734317331 0.4908211905650571 20.840983459968964 -13.999999999999998 0.3130635767408564 5.518800699077175 0.4801028692473658 0.9996787088485373 0.004107423429846002 17.490689103528616 0.17814502139149635 51.57264984486575 0.0171201651149852 1.0000000000000041e-14 13.999999999999998 -5.038697829829809 K(ub)DVETTSSVSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDVETTSSVSVK 12 1 Q96RL1;Q96RL1-2;D6RC40;D6RCQ3;Q96RL1-5;D6RDZ5;D6R9M3 Q96RL1 UIMC1 BRCA1-A complex subunit RAP80 1 5048600.0 1817500.0 1631500.0 1599600.0 True False 1759804.4573492005 2282966.4581601014 1180616.7730286226 1.0 1.2972841662186387 0.6708795219254017 20.746983700410947 -6.77764902511588 1.5449894314642194 1.168844801238962 0.666275307229242 0.7589873313801808 0.12559899586879997 0.2542498031197864 1.1985528923043627 0.06403943037374532 0.1514084194809726 1.668595142203599e-07 6.77764902511588 -0.5025694940097201 K(ub)DVETTSSVSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KDVETTSSVSVK 12 1 Q96RL1;Q96RL1-2;D6RC40;D6RCQ3;Q96RL1-5;D6RDZ5;D6R9M3 Q96RL1 UIMC1 BRCA1-A complex subunit RAP80 1 11795200.0 3794500.0 3456500.0 4544200.0 True False 5756533.915108278 2839660.569242239 3646036.8782063876 1.0 0.4932934663668747 0.6333736467073011 22.45676897671797 -10.475129512191986 9.248684436638113 1.0000061064429926 0.5633335565371118 0.928348382417213 0.05718749415184872 7.200777579950192e-06 4.0865035902990686e-07 0.05537232653939673 0.018457184371787016 3.34865563054943e-11 10.475129512191986 -0.4366725499058808 K(ub)DVETTSSVSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDVETTSSVSVK 12 1 Q96RL1;Q96RL1-2;D6RC40;D6RCQ3;Q96RL1-5;D6RDZ5;D6R9M3 Q96RL1 UIMC1 BRCA1-A complex subunit RAP80 1 3452820.0 1432700.0 867420.0 1152700.0 True False 1962407.9072617004 829094.5162256468 880456.0006016949 1.0 0.42248836908863996 0.44866105428114755 20.904193521491855 -10.529035548400238 6.251126294547963 1.000642019466366 0.43557471168489625 0.9983899282970106 0.010684953986690133 9.570560995346276e-05 7.210539735083588e-06 0.010356541461997147 0.0034485540704536155 2.957770353625806e-11 10.529035548400238 -0.5650673077814699 K(ub)DVETTSSVSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KDVETTSSVSVK 12 1 Q96RL1;Q96RL1-2;D6RC40;D6RCQ3;Q96RL1-5;D6RDZ5;D6R9M3 Q96RL1 UIMC1 BRCA1-A complex subunit RAP80 1 5537700.0 1817500.0 2654400.0 1065800.0 True False 1511331.7789019833 2640100.2203428512 1288653.8522975831 1.0 1.7468700501096746 0.8526611233132537 20.527388975845223 -6.685125221797354 1.8840497437063133 1.4703757706969545 0.8559480019868064 0.3475515812751503 0.3161949625733895 0.4272437411166706 2.9364489762182124 0.1344636743102959 0.35227917677098874 2.064784722656969e-07 6.685125221797354 -0.614427768710148 K(ub)DVETTSSVSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KDVETTSSVSVK 12 1 Q96RL1;Q96RL1-2;D6RC40;D6RCQ3;Q96RL1-5;D6RDZ5;D6R9M3 Q96RL1 UIMC1 BRCA1-A complex subunit RAP80 1 14147800.0 3794500.0 4356900.0 5996400.0 True False 4912055.050777255 4114434.684977091 4905116.728259767 1.0 0.8376198235657084 0.9985874908880776 22.22789529881042 -10.79845650591453 8.405507570557921 1.0016564912378327 0.9181036572279955 0.25658082927593795 0.06571477500431307 0.0020791116552121634 4.9851915074196106e-05 0.0648497633342341 0.02120935243262266 1.59053596616696e-11 10.79845650591453 -0.08355283400983726 K(ub)DVHMPK(ub)HPELADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDVHMPKHPELADK 14 2 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;P46783;Q9NQ39 A0A1W2PQS6;P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 2 5984000.0 402100.0 2264500.0 3317400.0 True False 389335.5555984122 3168726.659211499 2448473.4201332554 1.0 8.138806265307926 6.288851313284065 18.57065457751699 -9.207099526572996 11.5511988374992 1.0000000000013343 7.213828789265609 0.9376675913081273 0.7552409465989279 0.0 0.0 0.73125890213788 0.2437529673792933 6.207267669670104e-10 9.207099526572996 6.213828789264275 K(ub)DVHMPK(ub)HPELADK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KDVHMPKHPELADK 14 2 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;P46783;Q9NQ39 A0A1W2PQS6;P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 2 5101300.0 402100.0 3518400.0 1180800.0 True False 334363.9660503373 3499445.680852279 1427699.820597661 1.0 10.4659773066738 4.26989737399731 18.351059852951266 -9.956150349599788 11.03298671976884 1.000000138093928 7.367937340310534 0.5847733070298891 2.529539040092626 0.0 0.0 2.449215680461211 0.8164052146550191 1.1062407451562195e-10 9.956150349599788 6.367937202216606 K(ub)DWDDDQND ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDWDDDQND 9 1 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 1 13884000.0 4794200.0 5757100.0 3332700.0 True False 6285242.627098835 4898163.12100004 2987864.1735157697 1.0 0.7793117006941945 0.4753776983299877 22.58353700691443 -6.96663762297938 0.328735535171416 1.0375790427332805 0.20717941839694337 0.9999430307151591 0.0016233181220767102 0.07740955800520817 0.01292373819338513 0.00445507713739501 0.026536993103433226 1.0798473753124833e-07 6.96663762297938 -0.8303996243363372 down K(ub)DWDDDQND ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDWDDDQND 9 1 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 1 10556600.0 4416100.0 3783600.0 2356900.0 True False 4275913.322750927 5294411.2112133475 1739557.1845156038 1.0 1.2381942316377839 0.406827045641901 22.027801177736922 -6.830132175631535 1.3275248316355936 1.1272591528541116 0.3844272553758426 0.9060989569200191 0.10711821236013327 0.18065040147171268 0.6226240236299653 0.06335730732869661 0.14578689732937394 1.4786582964761084e-07 6.830132175631535 -0.742831897478269 down K(ub)DWDDDQND ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDWDDDQND 9 1 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 1 11979600.0 4794200.0 4561100.0 2624300.0 True False 6566745.298383494 4359575.520459291 2004494.3891550514 1.0 0.663886799680272 0.3052492974942227 22.64674706843732 -7.303774577407498 0.3006170370365808 1.0768919047765375 1.0791953961872453e-13 0.9998603934541228 0.0033518276879442913 0.10489852806376743 0.02110796318940952 0.013535263398017635 0.04916494220405469 4.9685014693630174e-08 7.303774577407498 -1.0768919047764296 down K(ub)DWDDDQND ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KDWDDDQND 9 1 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 1 11940790.0 4416100.0 6646900.0 877790.0 True False 3672182.8164011296 6611091.83039365 1061331.8305576055 1.0 1.800316640246347 0.28901933362831556 21.8082064531712 -6.762822633161609 1.601577590623183 1.4632491360996054 0.28266990475660225 0.702413211921602 0.3367703750564766 0.2782389527140527 1.4071830012084297 0.16584838319223016 0.3974996509655796 1.7265428719957458e-07 6.762822633161609 -1.1805792313430032 K(ub)EAAENSLVAYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEAAENSLVAYK 12 1 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 1 16294600.0 7872900.0 6083700.0 2338000.0 True False 10321448.141272046 5176035.674076859 2096086.1876796237 1.0 0.5014834743372503 0.203080629674248 23.299142065172447 -8.561294519288106 0.2621162010507443 1.2286049577881268 2.4589173968767914e-23 0.9992023668248299 0.009284469691198942 0.19285053364796123 0.07214249043792466 0.1412797346082912 0.1073961761650991 2.746031284686774e-09 8.561294519288106 -1.2286049577881268 down K(ub)EAAENSLVAYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEAAENSLVAYK 12 1 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 1 20429300.0 7566600.0 8532200.0 4330500.0 True False 7326402.424747444 11939151.954835216 3196212.137784728 1.0 1.6296063555704534 0.4362594289099411 22.804673516922957 -6.763344630048899 1.5997716767479202 1.3641831439948804 0.4311466409279835 0.7045190537169814 0.26495750642620974 0.2773309082479459 1.3995613398333386 0.13062922201488722 0.31290838552848327 1.7244689138079445e-07 6.763344630048899 -0.9330365030668969 K(ub)EAAENSLVAYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEAAENSLVAYK 12 1 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 1 40451900.0 18712800.0 13672500.0 8066600.0 True False 28388685.688928246 11232535.551269911 6472232.974283614 1.0 0.39566944642494195 0.22798635502903267 24.758812722363036 -13.999999999999984 0.17987245660644602 4.134371192606094 0.09461143337734425 0.9994982924377602 0.007426365262541642 12.20307472171817 0.13444574686947086 13.367294865419314 0.12533391399609722 1.0000000000000368e-14 13.999999999999984 -4.03975975922875 K(ub)EAAENSLVAYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEAAENSLVAYK 12 1 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 1 16327900.0 7872900.0 5823400.0 2631600.0 True False 10783723.887122655 5566102.932591399 2010070.2795032694 1.0 0.5161577754450984 0.18639852990891093 23.36235212669534 -8.235261438149882 0.3002237673707946 1.1467890234586593 1.6665246971402452e-21 0.9989663899035371 0.010742246094516364 0.09518450308326046 0.0698144789932362 0.08361555212616523 0.09518451999331907 5.817529066393869e-09 8.235261438149882 -1.1467890234586593 down K(ub)EAAENSLVAYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEAAENSLVAYK 12 1 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 1 23232810.0 7566600.0 14009300.0 1656910.0 True False 6291963.157215825 13933829.120271657 2003362.2203137425 1.0 2.2145439781051315 0.3184001829407126 22.585078792357233 -6.733689014745629 1.7096315908525554 1.7278773680444328 0.31871296026153123 0.5763569374454699 0.5104342771943671 0.32936006076568225 1.8875338912914508 0.2364349839431585 0.584296155137443 1.8463370525252445e-07 6.733689014745629 -1.4091644077829015 K(ub)EAAENSLVAYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEAAENSLVAYK 12 1 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 1 42632600.0 18712800.0 17242400.0 6677400.0 True False 24224088.484433953 16282845.282712264 5462181.715909835 1.0 0.6721757680655511 0.22548554177465763 24.529939044455485 -7.305628213805923 0.4011883787884401 1.031627921262055 1.992827328670983e-12 0.9994593731974052 0.00738075453648609 0.10258981420889299 0.03296083644746482 0.012105771158480041 0.05266739233474671 4.947340323951435e-08 7.305628213805923 -1.031627921260062 down K(ub)EACWTISNITAGNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEACWTISNITAGNR 15 1 O60684;Q5TFJ7;P52294 O60684;P52294 KPNA6;KPNA1 Importin subunit alpha-7;Importin subunit alpha-5;Importin subunit alpha-5, N-terminally processed 1 7143600.0 1614100.0 2866900.0 2662600.0 True False 2116100.7309666355 2439169.6950886725 2387099.693462686 1.0 1.1526718267208664 1.1280652468619763 21.012976873811606 -10.08407702273419 4.301229590937767 0.9999838826974602 1.1403685367998884 0.9774716925778886 0.010045594223809292 6981577.611755907 0.11670426646556604 1115.4169358388315 0.0034388740907656274 8.23991965925123e-11 10.08407702273419 0.14038465410242817 K(ub)EACWTISNITAGNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEACWTISNITAGNR 15 1 O60684;Q5TFJ7;P52294 O60684;P52294 KPNA6;KPNA1 Importin subunit alpha-7;Importin subunit alpha-5;Importin subunit alpha-5, N-terminally processed 1 40164100.0 5092100.0 15107000.0 19965000.0 True False 7725087.982375247 12411037.818470247 16018908.999029644 1.0 1.6065885394167643 2.0736215607610826 22.88111993354036 -6.974038357752221 0.12935574546391707 0.2696819781900267 3.4226098316124833 0.9999992369908763 0.0003838936420783063 0.07501277581640325 0.0038813226667798757 0.029593588348863942 0.06401517062480212 1.0616017902768703e-07 6.974038357752221 3.1529278534224567 K(ub)EACWTISNITAGNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEACWTISNITAGNR 15 1 O60684;Q5TFJ7;P52294 O60684;P52294 KPNA6;KPNA1 Importin subunit alpha-7;Importin subunit alpha-5;Importin subunit alpha-5, N-terminally processed 1 32701200.0 5092100.0 7875100.0 19734000.0 True False 6591823.830297237 7436843.7622307455 16142614.487939145 1.0 1.1281921291721482 2.4488843912582605 22.65224625563281 -6.925712839208586 0.7811686709164978 0.9764089216195024 2.692621860823948 0.9956267907559528 0.04330803010300918 0.09492536401244317 0.08903532430535369 0.03849243132097697 0.12243686367530053 1.1865530521466412e-07 6.925712839208586 1.7162129392044456 up K(ub)EAELDVNEELDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEAELDVNEELDKK 14 2 P43034;I3L495 P43034 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit alpha 1 10064700.0 2907300.0 3184700.0 3972700.0 True False 2815009.3528755624 4456367.317991097 2932130.691554647 1.0 1.5830737164119437 1.0416060211520946 21.424708284995496 -10.336032843574136 3.7590245222120062 0.999004773025421 1.312339868506206 0.30731524650583786 0.22105326114570314 28524791.51339476 26146422.97502963 206330.17243554507 0.07567241076974035 4.6128268868064565e-11 10.336032843574136 0.313335095480785 K(ub)EAELDVNEELDKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEAELDVNEELDKK 14 2 P43034;I3L495 P43034 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit alpha 1 20960600.0 8367600.0 12593000.0 0.0 True False 12694260.953501126 10345680.760441927 0.0 1.0 0.8149888204077409 0.0 23.597673069456476 -7.227827783916882 0.8699357286847398 0.9897673101481205 4.188302622153286e-16 0.9890632660179162 0.04543046148898536 0.0959034801424348 0.13898677730051198 0.03840092699391726 0.06751027507146681 5.917962598353138e-08 7.227827783916882 -0.98976731014812 down K(ub)EAELDVNEELDKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEAELDVNEELDKK 14 2 P43034;I3L495 P43034 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit alpha 1 8011500.0 2907300.0 3633000.0 1471200.0 True False 2417548.765227917 3613428.3079059576 1778821.1179397665 1.0 1.494666151052923 0.7357953409357871 21.205113560429773 -6.73080365194083 1.7204305481261855 1.2974184684302206 0.7361884854234207 0.5629729416835456 0.20793207474876235 0.33471170570082576 1.94127694227931 0.09576591287567825 0.23740885357627423 1.85864457345808e-07 6.73080365194083 -0.5612299830067998 K(ub)EAELDVNEELDKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEAELDVNEELDKK 14 2 P43034;I3L495 P43034 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit alpha 1 30672600.0 8367600.0 11395000.0 10910000.0 True False 10832023.150055012 10760858.232989972 8924491.946053313 1.0 0.99343013617316 0.8238988988874151 23.368799391548926 -6.915078296388714 0.8604286991180154 1.0044441299640061 0.7994317304577184 0.9927011484293562 0.006963706874800989 0.10115496803413307 0.12125783878090163 0.005848501910929781 0.016773444987135126 1.2159667614141315e-07 6.915078296388714 -0.2050123995062877 K(ub)EAPPMEKPEVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEAPPMEKPEVVK 13 2 P62841;K7EJ78;K7EQJ5;K7EM56;S4R417;K7ELC2;S4R456;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 1 11261700.0 3517000.0 3566200.0 4178500.0 True False 4610821.058676451 3034136.860938725 3746148.903002265 1.0 0.6580469773879454 0.8124689410691655 22.136592246618267 -10.06033433611727 4.581225134584819 1.0000110084348797 0.735257959221824 0.7967033477792445 0.06304250273408742 87421376.73016547 1.587989388363975 12100.813216799488 0.021581125510382545 8.702933476674937e-11 10.06033433611727 -0.26475304921305565 K(ub)EAPPMEKPEVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEAPPMEKPEVVK 13 2 P62841;K7EJ78;K7EQJ5;K7EM56;S4R417;K7ELC2;S4R456;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 1 14130600.0 2697800.0 4947700.0 6485100.0 True False 2612159.8157010605 6923342.411914654 4786457.761170247 1.0 2.6504283429750806 1.8323755431807838 21.316811735069955 -10.105241042237205 5.629759442583704 0.9999886072223855 2.241401943078134 0.7543264383122458 0.33396865702591094 4.775696388152639e-05 7.589379950673483e-06 0.3233667226946624 0.10778792056794716 7.84799933844846e-11 10.105241042237205 1.2414133358557486 K(ub)EAPPMEKPEVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEAPPMEKPEVVK 13 2 P62841;K7EJ78;K7EQJ5;K7EM56;S4R417;K7ELC2;S4R456;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 1 22514900.0 3944100.0 5347800.0 13223000.0 True False 5983488.0523332525 4393443.307447892 10609468.254153207 1.0 0.7342612317467024 1.7731243317208698 22.512555312738932 -6.838856714345929 1.2877472337136875 0.8586079275632709 1.8065161026614653 0.9224628369387359 0.1227019863326842 0.17013784205301122 0.5485590561177044 0.07473036019705313 0.1721101013816359 1.4492499219512813e-07 6.838856714345929 0.9479081750981945 K(ub)EAPPMEKPEVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEAPPMEKPEVVK 13 2 P62841;K7EJ78;K7EQJ5;K7EM56;S4R417;K7ELC2;S4R456;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 1 12444000.0 3517000.0 3467100.0 5459900.0 True False 4817329.943351298 3313912.0578335053 4170384.0701702014 1.0 0.6879146948211935 0.8657044709852213 22.19980230814116 -10.171870689777913 5.195419643677114 1.0000111223325292 0.776809583695379 0.6775486350875416 0.07258237218139127 9.35126618560683e-06 1.490524096812421e-06 0.07028108096002705 0.02342585989049484 6.731770634301907e-11 10.171870689777913 -0.2232015386371502 K(ub)EAPPMEKPEVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEAPPMEKPEVVK 13 2 P62841;K7EJ78;K7EQJ5;K7EM56;S4R417;K7ELC2;S4R456;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 1 12421200.0 2697800.0 6974300.0 2749100.0 True False 2243340.2328042774 6936728.061609834 3323924.0995977568 1.0 3.09214267197384 1.481685234808409 21.09721701050423 -6.5800353718077655 2.267352166082294 2.424671206617918 1.4857236516537313 0.0 0.9088834877587821 0.6991109218619583 6.76051226257881 0.3366379082482556 1.0156346460517498 2.6300537742412934e-07 6.5800353718077655 -0.9389475549641866 K(ub)EAPPMEKPEVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 KEAPPMEKPEVVK 13 2 P62841;K7EJ78;K7EQJ5;K7EM56;S4R417;K7ELC2;S4R456;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 1 30585900.0 4969600.0 7973200.0 17643100.0 True False 6433245.165461223 7529484.410993901 14432236.833493412 1.0 1.170402218062225 2.2433836209098854 22.61711523892827 -6.934822282416896 0.7060912542319193 0.9862315133021118 2.493396489664407 0.9974039821464257 0.0280428204963504 0.09021002722208753 0.06597358368330615 0.026325653462385853 0.09464470640860553 1.1619239873193673e-07 6.934822282416896 1.5071649763622952 up K(ub)EDLYLKPIQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEDLYLKPIQR 11 2 P13639 P13639 EEF2 Elongation factor 2 1 7669200.0 2761000.0 2833000.0 2075200.0 True False 3619697.7375620315 2410327.4429475074 1860478.2107240155 1.0 0.6658919107900239 0.5139871739614092 21.787437799581028 -13.999999999999893 0.10615353471859766 2.624314487212345 0.219232977856236 0.9997626167020894 0.003127795640339422 12.036652306244532 0.09821682411530615 4.222383300096896 0.2621171243755068 1.0000000000002453e-14 13.999999999999893 -2.4050815093561093 K(ub)EDLYLKPIQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEDLYLKPIQR 11 2 P13639 P13639 EEF2 Elongation factor 2 1 14616000.0 3070600.0 3506000.0 8039400.0 True False 2973125.4837614642 4905964.083548469 5933639.963169728 1.0 1.650103270226477 1.9957583343111218 21.50354892425488 -9.797063933275584 0.15068295449510347 9.598854408576631e-14 2.5212134877010786 0.9997471523189075 0.006564031807983497 1.3062966116075148 0.06620930229778954 0.8296180607727754 0.295904467078675 1.5956442322747766e-10 9.797063933275584 2.5212134877009826 K(ub)EDLYLKPIQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEDLYLKPIQR 11 2 P13639 P13639 EEF2 Elongation factor 2 1 39973700.0 6450700.0 11253000.0 22270000.0 True False 9786183.509339565 9244814.2299097 17868324.73871226 1.0 0.9446802444575862 1.825872641940487 23.222314905593173 -6.8919419855437765 1.0108428825839073 0.9548330770469858 1.9046055934448214 0.9821117859874909 0.05389895616443365 0.1175809093304186 0.21276622778755952 0.04052132801360219 0.10175093608252936 1.2825018919487914e-07 6.8919419855437765 0.9497725163978356 K(ub)EDLYLKPIQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEDLYLKPIQR 11 2 P13639 P13639 EEF2 Elongation factor 2 1 9220600.0 2761000.0 2663900.0 3795700.0 True False 3781816.313219481 2546200.089660721 2899233.8348953337 1.0 0.6732743948351967 0.7666247101322592 21.85064786110392 -10.188911625396742 7.603691558507767 1.0000001905331044 0.7199495524837283 0.9230766687243082 0.03811010663428837 1.2309601438723504e-07 1.3124979708064487e-08 0.036899977097066786 0.01229998402639898 6.4727431622739e-11 10.188911625396742 -0.28005063804937613 K(ub)EDLYLKPIQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEDLYLKPIQR 11 2 P13639 P13639 EEF2 Elongation factor 2 1 11098100.0 3070600.0 5005300.0 3022200.0 True False 2553339.950644531 4978335.455425742 3654128.0469260244 1.0 1.949734681497886 1.4311169360756781 21.283954199689155 -10.250540624130867 4.919344860629922 0.9998580066882696 1.6904258087874742 0.7026533279251322 0.2117248079752323 0.0003297894521110387 5.024360611916505e-05 0.20504328595351973 0.06833388793857834 5.616417396390879e-11 10.250540624130867 0.6905678020992045 K(ub)EDLYLKPIQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEDLYLKPIQR 11 2 P13639 P13639 EEF2 Elongation factor 2 1 30772200.0 6450700.0 9830500.0 14491000.0 True False 8350558.3123069815 9283424.033295995 11853786.690216165 1.0 1.1117129760789963 1.419520258034263 22.993441227685622 -6.9533460248043495 0.5208173570543427 0.9948023904493384 1.5501863934595095 0.999438374479546 0.004204027233311247 0.08216934274176652 0.03061241585764716 0.0047564522877740194 0.02542710960444954 1.11340707127835e-07 6.9533460248043495 0.5553840030101711 K(ub)EELELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEELELK 7 1 H7C563;Q9P2D7-6;Q9P2D7-8;Q9P2D7 H7C563 DNAH1 Dynein heavy chain 1, axonemal 1 14605800.0 4920700.0 5065000.0 4620100.0 True False 7465061.651356778 4161111.1769743753 3706935.2099382314 1.0 0.5574114952176037 0.4965712787200484 22.831722744451493 -13.999999999999998 0.27960104647806805 4.599136113012762 0.47818360553040334 0.9996042947677837 0.004462992190913994 15.376818047374963 0.16749974577529597 31.63895789002728 0.02411262742832938 1.0000000000000041e-14 13.999999999999998 -4.120952507482359 K(ub)EELTLEGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEELTLEGIR 10 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 1 8712400.0 4340700.0 2632100.0 1739600.0 True False 5690699.735398595 2239400.939845444 1559602.8794215012 1.0 0.39351943415946006 0.2740617062819361 22.440174628309805 -13.999999999999998 0.22842071067567316 4.800762445064987 0.215100639574494 0.9995076781809945 0.007051849811453073 13.242553312636042 0.15133988647058827 22.8071969208747 0.06262412742759417 1.0000000000000041e-14 13.999999999999998 -4.585661805490493 K(ub)EELTLEGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEELTLEGIR 10 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 1 18023700.0 2912800.0 6128100.0 8982800.0 True False 2820334.758386112 8575082.28761933 6629935.201776393 1.0 3.040448394333967 2.3507617959402305 21.427434982161145 -10.162535236894078 5.425450492984477 0.9999515045380135 2.6956050951374633 0.8896133161134073 0.2815633747513606 0.00016516801912572408 2.5496182329392254e-05 0.2726302629092588 0.09087418844264603 6.878041044074446e-11 10.162535236894078 1.6956535905994499 K(ub)EELTLEGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEELTLEGIR 10 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 1 9940800.0 4340700.0 5600100.0 0.0 True False 5945574.093006813 5352669.064945754 0.0 1.0 0.9002779178618875 0.0 22.503384689832696 -7.116449888490834 0.9721471154023105 0.9981605834278107 7.684055320556211e-19 0.9896236227767834 0.04581317362844533 0.08544535894259102 0.15324592420045416 0.03798700631015289 0.06694745013298571 7.648039310248437e-08 7.116449888490834 -0.9981605834278107 down K(ub)EELTLEGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEELTLEGIR 10 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 1 83163900.0 13063900.0 13788000.0 56312000.0 True False 16911476.07796782 13020685.67937392 46063793.80991325 1.0 0.7699319455820418 2.723818642296098 24.011499251660553 -6.877538297045069 1.093460317312524 0.8615668632052789 2.8559018066337183 0.9716432526542482 0.1468261508971121 0.1298328323219762 0.28566871974738556 0.10365635285016139 0.24916820023134176 1.325750205029357e-07 6.877538297045069 1.9943349434284394 up K(ub)EFSPFGSITSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEFSPFGSITSAK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 21705700.0 6532500.0 9183600.0 5989600.0 True False 8564170.760819985 7813442.677392419 5369853.648300197 1.0 0.9123408320088557 0.6270138462052403 23.029882131200342 -6.949603766474044 0.5631750618843927 1.0036715230151365 0.521972349882377 0.9991698326295143 0.004588097606932509 0.0836452140233007 0.03662358953695629 0.004899530402151945 0.02373512394678931 1.1230426077692214e-07 6.949603766474044 -0.48169917313275956 K(ub)EFSPFGSITSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEFSPFGSITSAK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 31981000.0 12531800.0 14066900.0 5382300.0 True False 12133984.8685605 19683886.527914397 3972514.164461089 1.0 1.6222112307817282 0.3273874335177379 23.532550081612563 -6.776006187198616 1.5511717189285812 1.3541310650093834 0.3183378880316614 0.7531135146443044 0.2627201299390629 0.25681829647178345 1.2201922092224244 0.13343172708885126 0.3159440767541074 1.674919014036803e-07 6.776006187198616 -1.035793176977722 K(ub)EFSPFGSITSAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEFSPFGSITSAK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 67857600.0 19754600.0 26434000.0 21669000.0 True False 29969172.454710234 21716646.17021532 17386112.652139917 1.0 0.7246328273839984 0.5801332245130898 24.836975911160483 -13.999999999996385 0.0811450349288348 2.4747612658174583 0.15761986447100784 0.9998819063437366 0.0018926382528739892 12.247251923531316 0.08048128583680123 3.225337747513739 0.38317580491981884 1.0000000000083236e-14 13.999999999996385 -2.3171414013464506 K(ub)EFSPFGSITSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEFSPFGSITSAK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 24488200.0 6532500.0 7884900.0 10070800.0 True False 8947741.78417467 7536519.046122528 7692284.4546365505 1.0 0.842281687146126 0.8596900357855017 23.093092192723233 -10.06729404192997 4.823338751693971 1.0000047257479832 0.8509858614639274 0.9898679110165846 0.007106928578323957 3.6116911359468723e-07 6.983977853907291e-08 0.00688147219276938 0.0022937513346200184 8.564577785222375e-11 10.06729404192997 -0.14901886428405575 K(ub)EFSPFGSITSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEFSPFGSITSAK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 27901900.0 12531800.0 14034400.0 1335700.0 True False 10420746.952871457 13958793.90158971 1614988.694420983 1.0 1.3395195147448944 0.15497820854156427 23.31295535704684 -6.830092073328102 1.3275625407164993 1.1814098872033734 0.12306361953675861 0.90602897792399 0.1526753309680706 0.18071334600643368 0.6228682007650809 0.09029608194543859 0.2077893415477082 1.4787948405584613e-07 6.830092073328102 -1.0583462676666147 down K(ub)EFSPFGTITSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEFSPFGTITSAK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;H0YB86 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 33716100.0 9704800.0 12812300.0 11199000.0 True False 12723086.781416893 10900754.781954244 10040234.908393541 1.0 0.8567696636224855 0.789135143136658 23.60094539332337 -13.999999999981242 0.09986887113709439 1.7076215449063317 0.644787534160155 0.999794370387106 0.0012605963125205029 12.081420056604202 0.09408659761891411 1.7625288879907872 0.1287485003213649 1.0000000000431927e-14 13.999999999981242 -1.0628340107461767 K(ub)EFSPFGTITSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEFSPFGTITSAK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;H0YB86 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 40697900.0 14448900.0 14731000.0 11518000.0 True False 13990227.578428 20613165.121150143 8501090.267406648 1.0 1.4733974129866387 0.6076448878154608 23.737916095163026 -6.758229690239775 1.6191129516053684 1.2755795885575918 0.6047534163673207 0.6837090924541666 0.19906496567211168 0.2859009348199673 1.4767709842203238 0.09702482816071982 0.2335773109858946 1.7448990643157734e-07 6.758229690239775 -0.6708261721902711 K(ub)EFSPFGTITSAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEFSPFGTITSAK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;H0YB86 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 55978700.0 23990000.0 12961000.0 19027700.0 True False 36394583.90392611 10648008.285244782 15266866.754862819 1.0 0.29257123294370496 0.4194818326585096 25.117220434516682 -10.432912852268913 5.878092140859498 1.0002988666583736 0.3560265328141572 0.9716957648761397 0.051811035375313924 0.00020301688508293742 1.9586059954461092e-05 0.05018827291808515 0.016721939763195994 3.690516469137097e-11 10.432912852268913 -0.6442723338442164 K(ub)EFSPFGTITSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEFSPFGTITSAK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;H0YB86 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 39023300.0 9704800.0 20533000.0 8785500.0 True False 13292926.822358731 19625784.16644906 6710545.843052119 1.0 1.4764080498388397 0.5048207917435434 23.664155454846263 -6.773378629691821 1.5614241096931525 1.2720840969192633 0.4986361870536958 0.7432928890783186 0.2009796802800059 0.26103207198315587 1.2563958227624725 0.10142612626370665 0.2407053933616597 1.6850832835558124e-07 6.773378629691821 -0.7734479098655676 K(ub)EFSPFGTITSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEFSPFGTITSAK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;H0YB86 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 35187800.0 14448900.0 18933000.0 1805900.0 True False 12014900.54480159 18831004.17109374 2183505.3404618204 1.0 1.5673042070449124 0.18173311816605456 23.518321370597302 -6.795500505535811 1.474066495221339 1.3147952987413067 0.16461768208203745 0.8187811765144262 0.2421121412167762 0.22720585788519262 0.9750396885848012 0.1292414173666421 0.3014482989043983 1.601398784252273e-07 6.795500505535811 -1.1501776166592692 down K(ub)EFSPFGTITSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEFSPFGTITSAK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;H0YB86 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 64946400.0 23990000.0 38273000.0 2683400.0 True False 31055527.91359767 36143073.90532906 2195048.734009117 1.0 1.1638209469787764 0.07068141749565991 24.88834675660913 -6.868749207442181 1.14076523246833 1.0919765538741915 0.008185338169580341 0.9634149940816273 0.0920719901394891 0.1380558942215617 0.33657170319841895 0.06268693022473414 0.14809222947881442 1.3528535716499276e-07 6.868749207442181 -1.083791215704611 down K(ub)EGGGDSSASSPTEEEQEQGEIGACSDEGTAQEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEGGGDSSASSPTEEEQEQGEIGACSDEGTAQEGK 35 1 P49006 P49006 MARCKSL1 MARCKS-related protein 1 21097000.0 11708000.0 7432400.0 1956600.0 True False 16036763.996803235 7104011.992339927 1494491.377441897 1.0 0.4429828856841716 0.09319158015543588 23.934879718924602 -8.368820011173995 0.3820626926953519 1.0973194915417548 1.7140729830147188e-17 0.9973611051644663 0.019182199306124095 0.13740186400298712 0.10655119433151515 0.08384222117819731 0.08335893412475057 4.277401218620346e-09 8.368820011173995 -1.0973194915417548 K(ub)EGTGSTATSSSSTAGAAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEGTGSTATSSSSTAGAAGK 20 1 A0A087WZK9;B3KS98;O15372;E5RGU4;E5RHC7;E5RH59;E5RFW7;E5RFH0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 5753800.0 1192800.0 3217800.0 1343200.0 True False 1563772.3510916326 2737716.7828861587 1204218.548884204 1.0 1.750713127121747 0.7700727973886783 20.57659907438904 -6.702153178887719 1.823349260127341 1.4651760406522207 0.7728829711796628 0.4277632052749585 0.3167618115522444 0.3910427867351589 2.529011376351778 0.13852179398378484 0.3552767943247347 1.9853945304594868e-07 6.702153178887719 -0.692293069472558 K(ub)EGTGSTATSSSSTAGAAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEGTGSTATSSSSTAGAAGK 20 1 A0A087WZK9;B3KS98;O15372;E5RGU4;E5RHC7;E5RH59;E5RFW7;E5RFH0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 4744000.0 1192800.0 2337800.0 1213400.0 True False 1633810.3942079693 2234508.265929212 926819.9107574354 1.0 1.367666819755083 0.5672750730703575 20.639809135911932 -6.781776072758888 1.5287083549871612 1.2076975342899212 0.5605491926648652 0.7737221570670036 0.1556057670556598 0.2478136672961369 1.143953552474871 0.08015830717233803 0.18888032118289136 1.6528137884039444e-07 6.781776072758888 -0.647148341625056 K(ub)EGTGSTATSSSSTAGAAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEGTGSTATSSSSTAGAAGK 20 1 A0A087WZK9;B3KS98;O15372;E5RGU4;E5RHC7;E5RH59;E5RFW7;E5RFH0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 6032800.0 1870300.0 3671300.0 491200.0 True False 1555237.3183385867 3651521.978204006 593907.648947808 1.0 2.347887319283733 0.38187589890285145 20.568703311652154 -6.72214463708739 1.7512305305703593 1.8181355310362421 0.3844872882727566 0.5227751455260139 0.5670517315402281 0.35117219914777487 2.105819445574233 0.2569689513972321 0.643556295514554 1.8960743489610066e-07 6.72214463708739 -1.4336482427634856 K(ub)EITGIGPSTTTETETIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEITGIGPSTTTETETIAK 19 1 O75436;S4R3Q6;O75436-2 O75436 VPS26A Vacuolar protein sorting-associated protein 26A 1 24142900.0 7805000.0 8359300.0 7978600.0 True False 11840755.62193177 6867517.603490994 6401626.212855389 1.0 0.5799898100059417 0.540643386051995 23.497257814201156 -13.999999999999998 0.334968363678807 5.7114617652646675 0.5340740378324691 0.9997250590777778 0.0034470946020668603 19.251559336746638 0.18535087819638363 64.0636022906613 0.012379428212044945 1.0000000000000041e-14 13.999999999999998 -5.177387727432198 K(ub)EITGIGPSTTTETETIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEITGIGPSTTTETETIAK 19 1 O75436;S4R3Q6;O75436-2 O75436 VPS26A Vacuolar protein sorting-associated protein 26A 1 23413100.0 7805000.0 9291600.0 6316500.0 True False 10103726.359551052 8774514.292027177 5166961.812763133 1.0 0.8684433821520344 0.5113917013279763 23.268384136293605 -6.953678681305167 0.5168879920981739 1.0062164735813042 0.35776921223321473 0.999459220596038 0.004800525763786949 0.08204143182790767 0.030103453332045997 0.005465722998551061 0.02948405221795662 1.1125545615155387e-07 6.953678681305167 -0.6484472613480894 K(ub)ELATVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KELATVR 7 1 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7;H0Y9R4 P32969 RPL9 60S ribosomal protein L9 1 11480400.0 3769200.0 6562000.0 1149200.0 True False 4941457.700984726 5582975.178475664 1030291.8079047994 1.0 1.129823529069792 0.20849957042017875 22.23650526047872 -6.871211349987555 1.127602479676455 1.0739977895212416 0.15327003807861783 0.9658805674966724 0.07521215905594386 0.13570205812259292 0.32173338584089456 0.05172413471855978 0.12272927110634331 1.3452055486675247e-07 6.871211349987555 -0.9207277514426238 down K(ub)ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KELEQVCNPIISGLYQGAGGPGPGGFGAQGPK 32 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 52990700.0 24781000.0 18661000.0 9548700.0 True False 23994340.719433576 26112434.615829445 7047609.015140286 1.0 1.088274727826982 0.2937196357069425 24.516190837596103 -6.879331590185661 1.0835794886941756 1.054234797415399 0.2381399775042428 0.9731396809649852 0.05827662917425699 0.12822106571540048 0.27591053308762736 0.04145546966803082 0.10007703768564244 1.3202871906842e-07 6.879331590185661 -0.8160948199111562 down K(ub)ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KELEQVCNPIISGLYQGAGGPGPGGFGAQGPK 32 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 286277000.0 95536000.0 122230000.0 68511000.0 True False 144935096.61715224 100417101.51265098 54969770.82056196 1.0 0.6928418571928366 0.37927163332815966 27.110831750711778 -7.103722625346204 0.25191755992972986 1.1042409401239237 7.802330793345774e-15 0.9999804561533415 0.0011202964177774554 0.0768422342952826 0.009873705258429944 0.008381673870913094 0.03152996170849531 7.87548619667064e-08 7.103722625346204 -1.104240940123916 down K(ub)ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KELEQVCNPIISGLYQGAGGPGPGGFGAQGPK 32 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 50016000.0 10923000.0 22847000.0 16246000.0 True False 14961528.282975871 21837543.995074324 12409029.396872655 1.0 1.459579768994749 0.8293958452755389 23.83475421468152 -6.711166936642363 1.7909308719869241 1.282203755742377 0.8308195640635665 0.4706529390364046 0.19362990942553254 0.3727574712799089 2.331298175823851 0.0860128453356382 0.21821375027819007 1.9446124564818196e-07 6.711166936642363 -0.4513841916788106 K(ub)ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KELEQVCNPIISGLYQGAGGPGPGGFGAQGPK 32 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 43469400.0 24781000.0 8527400.0 10161000.0 True False 20606499.484440185 8481461.20364363 12285618.120844197 1.0 0.41159155683127635 0.5962011223750533 24.29659611303038 -10.632711335993656 7.166017496487504 1.001157645102667 0.5038963396031694 0.9059165965180083 0.0753665395365234 0.0013966490387049093 7.158414013300595e-05 0.07311689313498076 0.02432444604051983 2.3296391924635466e-11 10.632711335993656 -0.49726130549949754 K(ub)ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KELEQVCNPIISGLYQGAGGPGPGGFGAQGPK 32 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 234621000.0 95536000.0 93538000.0 45547000.0 True False 123673235.29610106 88332528.0734898 37257913.351685606 1.0 0.7142412653958814 0.3012609257167238 26.881958072804228 -7.055778484886935 0.359797351721393 1.0379837357891057 1.378427036582944e-12 0.9999120854842763 0.0026893978892218026 0.0733139090153228 0.015267429510745528 0.005898286607840274 0.03365472624063636 8.794709831299672e-08 7.055778484886935 -1.0379837357877273 down K(ub)ELTQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KELTQIK 7 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;B3KT61;Q86SE5;Q86SE5-3;E5RJ39;Q86SE5-2;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC;RALYL Heterogeneous nuclear ribonucleoproteins C1/C2;RNA-binding Raly-like protein 1 9211700.0 3026400.0 4495500.0 1689800.0 True False 3967639.7076992854 3824788.923321749 1514955.7057061691 1.0 0.9639960291504465 0.38182794238256235 21.91984959315497 -6.919535647514853 0.8281689624162005 1.0130616279315763 0.2889452805917856 0.9940507903412916 0.021851588102908198 0.0984459349308518 0.10703775567352464 0.01878117812087285 0.05601077443040768 1.2035505965750948e-07 6.919535647514853 -0.7241163473397907 down K(ub)ELTQIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KELTQIK 7 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;B3KT61;Q86SE5;Q86SE5-3;E5RJ39;Q86SE5-2;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC;RALYL Heterogeneous nuclear ribonucleoproteins C1/C2;RNA-binding Raly-like protein 1 7871500.0 3537400.0 3296800.0 1037300.0 True False 3425107.173274864 4613229.432584884 765600.0116670352 1.0 1.346886155440799 0.22352585566980038 21.70771770073547 -6.823800779064509 1.3554547279990319 1.186288433404795 0.1969701325269752 0.8928648179311625 0.15372510467381612 0.18860191419443925 0.6798271136583903 0.08909886737726648 0.20516948410945898 1.500372933474701e-07 6.823800779064509 -0.9893183008778197 down K(ub)ELTQIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KELTQIK 7 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;B3KT61;Q86SE5;Q86SE5-3;E5RJ39;Q86SE5-2;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC;RALYL Heterogeneous nuclear ribonucleoproteins C1/C2;RNA-binding Raly-like protein 1 7234300.0 3026400.0 2396300.0 1811600.0 True False 4145341.8653847994 2290423.5424955823 1383737.3910731568 1.0 0.5525294696732977 0.3338053738409121 21.983059654677863 -10.84623629764066 0.1395755015901983 1.9511503369564 6.497731186272484e-20 0.999724344816012 0.004603398422543004 2.9297453904032595 0.07913819982819431 1.1331375995120507 0.22290108739819114 1.424832138012866e-11 10.84623629764066 -1.9511503369564 K(ub)ELTQIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KELTQIK 7 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;B3KT61;Q86SE5;Q86SE5-3;E5RJ39;Q86SE5-2;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC;RALYL Heterogeneous nuclear ribonucleoproteins C1/C2;RNA-binding Raly-like protein 1 8190530.0 3537400.0 4192700.0 460430.0 True False 2941504.8333908548 4170113.092914209 556703.7842122127 1.0 1.4176801770225416 0.18925815721691872 21.488122976169745 -6.814970481366472 1.3936417019948748 1.2263324895241874 0.1652567208664785 0.8723849975794151 0.18218385401287276 0.2001012782005902 0.7649972960177086 0.10276444815402033 0.2372143968408263 1.5311915319558952e-07 6.814970481366472 -1.0610757686577088 down K(ub)EMEELDTLNIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEMEELDTLNIR 12 1 Q58WW2;Q58WW2-2;Q58WW2-4;Q58WW2-3 Q58WW2 DCAF6 DDB1- and CUL4-associated factor 6 1 28666800.0 9542200.0 13960000.0 5164600.0 True False 12509916.606796244 11877222.415653815 4630216.73434139 1.0 0.9494245876268507 0.37012370904422653 23.57656883650004 -6.924076490118412 0.7939068471195694 1.0110035326927431 0.26734683446884927 0.9952404006376293 0.01971403595232788 0.09583228191935618 0.09361734052781848 0.01736327038604823 0.05422373636942897 1.1910322189961567e-07 6.924076490118412 -0.7436566982238939 down K(ub)EMEELDTLNIR ddPTM_RPMI8226_Bortezomib_2h_R1 2 KEMEELDTLNIR 12 1 Q58WW2;Q58WW2-2;Q58WW2-4;Q58WW2-3 Q58WW2 DCAF6 DDB1- and CUL4-associated factor 6 1 40315600.0 15371400.0 15506300.0 9437900.0 True False 14883443.320878979 21698046.454286233 6965830.859069048 1.0 1.4578646880623052 0.46802549039825714 23.82720500028595 -6.780927322562419 1.5322689479951555 1.2589407401734207 0.4599564741142932 0.7706588047056634 0.19370258957386183 0.24913368986856604 1.1554048007806978 0.09956187185080985 0.234741644066626 1.656047073109904e-07 6.780927322562419 -0.7989842660591275 down K(ub)EMEELDTLNIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEMEELDTLNIR 12 1 Q58WW2;Q58WW2-2;Q58WW2-4;Q58WW2-3 Q58WW2 DCAF6 DDB1- and CUL4-associated factor 6 1 27971700.0 14067000.0 7760500.0 6144200.0 True False 21340667.43545343 6375578.141936746 4929796.176901473 1.0 0.29875251845895623 0.23100477957458637 24.34710196177786 -13.999999999999998 0.3304882118057896 8.656037693038872 0.21907517059029064 0.9997158545865975 0.005860055296363 18.864501721248555 0.18385769508060779 100.41421633638244 0.021670385881197043 1.0000000000000041e-14 13.999999999999998 -8.436962522448582 K(ub)EMEELDTLNIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEMEELDTLNIR 12 1 Q58WW2;Q58WW2-2;Q58WW2-4;Q58WW2-3 Q58WW2 DCAF6 DDB1- and CUL4-associated factor 6 1 29921900.0 9542200.0 16204000.0 4175700.0 True False 13070209.208258944 15488053.700537669 3189485.6612409935 1.0 1.1849889664161544 0.24402713150341826 23.639778898022932 -6.855656610316048 1.2074160439334 1.0994278674136966 0.20208442469591134 0.9481471710936915 0.09268767919253973 0.15134342948982882 0.42173857195424247 0.05996830494693196 0.13937497618567435 1.394258785295881e-07 6.855656610316048 -0.8973434427177852 down K(ub)EMEELDTLNIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEMEELDTLNIR 12 1 Q58WW2;Q58WW2-2;Q58WW2-4;Q58WW2-3 Q58WW2 DCAF6 DDB1- and CUL4-associated factor 6 1 30003600.0 11864000.0 15944000.0 2195600.0 True False 9865441.664315345 15858106.507363781 2654689.8086926034 1.0 1.6074400971549736 0.2690898085480532 23.233952209492898 -6.783271548370934 1.522771073395005 1.3424808823274017 0.25731123251363847 0.778920165980925 0.25726690144498 0.24551762640242658 1.1246185181166943 0.1330292931779793 0.31309262300221463 1.6471321782942622e-07 6.783271548370934 -1.0851696498137633 K(ub)EMEELDTLNIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEMEELDTLNIR 12 1 Q58WW2;Q58WW2-2;Q58WW2-4;Q58WW2-3 Q58WW2 DCAF6 DDB1- and CUL4-associated factor 6 1 28879700.0 14067000.0 9863200.0 4949500.0 True False 18210008.802024916 9314304.249550393 4048741.7861586506 1.0 0.5114936709154507 0.22233606969527872 24.11822828387031 -8.626730545850773 0.24500800066758163 1.261318057999679 2.08666689549516e-11 0.9993415991563429 0.0082350538833445 0.22378694329996637 0.06895098387518529 0.1585999846297476 0.11343528173935502 2.3619432253329063e-09 8.626730545850773 -1.2613180579788124 down K(ub)EMQPTHPIR ddPTM_RPMI8226_Bortezomib_1h_R1 2 KEMQPTHPIR 10 1 P27348;P31946;P31946-2;P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6 P27348;P31946;P31946-2;P63104 YWHAQ;YWHAB;YWHAZ 14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta 1 52978800.0 19344300.0 24264700.0 9369800.0 True False 25360564.63046769 20644501.343059804 8400302.977468152 1.0 0.81403949966705 0.33123485615837556 24.59608353037133 -6.954646934375073 0.5052616722991934 1.009243475883115 0.11501987589972991 0.9995172924209904 0.006192298810014892 0.08167172512452024 0.028642441650293667 0.007192075910848935 0.03983589906009925 1.1100769006945912e-07 6.954646934375073 -0.8942235999833851 down K(ub)EMQPTHPIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEMQPTHPIR 10 1 P27348;P31946;P31946-2;P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6 P27348;P31946;P31946-2;P63104 YWHAQ;YWHAB;YWHAZ 14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta 1 39135300.0 17501000.0 14987300.0 6647000.0 True False 16945440.33456305 20971807.04773702 4905951.294274353 1.0 1.237607676972638 0.28951453591134174 24.014393790572335 -6.840324857637175 1.280884471860295 1.1263961948907715 0.2581292904061215 0.9250131477571737 0.11029776508346167 0.1684181401093897 0.536609592476222 0.06751844354001865 0.15556323609076428 1.4443589682195328e-07 6.840324857637175 -0.86826690448465 down K(ub)EMQPTHPIR ddPTM_RPMI8226_Bortezomib_8h_R1 2 KEMQPTHPIR 10 1 P27348;P31946;P31946-2;P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6 P27348;P31946;P31946-2;P63104 YWHAQ;YWHAB;YWHAZ 14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta 1 72570100.0 42633000.0 1062100.0 28875000.0 True False 64677377.889790766 872559.9567748233 23167843.593637887 1.0 0.013490960599263187 0.35820629019802763 25.94675785535959 -10.549861484178205 6.291927190223676 1.0011980264138645 0.18584862539865038 0.8814816941276578 0.1407294440053827 0.0023677947933572223 0.00016939710404005912 0.1364199154112433 0.04542023274615635 2.8192819822706522e-11 10.549861484178205 -0.815349401015214 K(ub)EMQPTHPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 KEMQPTHPIR 10 1 P27348;P31946;P31946-2;P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6 P27348;P31946;P31946-2;P63104 YWHAQ;YWHAB;YWHAZ 14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta 1 53678900.0 19344300.0 21287700.0 13046900.0 True False 26496410.470051322 20347139.024989877 9965490.929340033 1.0 0.767920584865187 0.3761072066951841 24.659293591894222 -6.963217976350814 0.38742065583145985 1.0247661970331101 0.10524132149464477 0.9998715681732545 0.0029178530675613044 0.07857099408006898 0.01702523323459571 0.005066868029893776 0.0329953503268287 1.0883836865494096e-07 6.963217976350814 -0.9195248755384653 down K(ub)EMQPTHPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEMQPTHPIR 10 1 P27348;P31946;P31946-2;P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6 P27348;P31946;P31946-2;P63104 YWHAQ;YWHAB;YWHAZ 14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta 1 34599064.0 17501000.0 17021900.0 76164.0 True False 14552856.925757136 16930199.646117397 92089.54025745267 1.0 1.1633591763107762 0.006327935519963999 23.79479906600661 -6.924594048409841 1.2290260778516882 1.087829104221997 9.548627481365999e-21 0.9643830350436352 0.0964936950633644 0.11820450778089356 0.35471146107150886 0.06444031520464552 0.12698889571208327 1.1896136851071183e-07 6.924594048409841 -1.087829104221997 down K(ub)EMQPTHPIR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 KEMQPTHPIR 10 1 P27348;P31946;P31946-2;P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6 P27348;P31946;P31946-2;P63104 YWHAQ;YWHAB;YWHAZ 14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta 1 92973400.0 42633000.0 18540400.0 31800000.0 True False 55189258.92206787 17508610.44167855 26012726.2955541 1.0 0.31724670313841796 0.4713367565287727 25.71788417745204 -10.216181303899834 8.162983684416053 1.000000242082994 0.3942917298383021 0.9537087164059442 0.0629070008740977 2.7714143880676313e-07 2.6685010783107814e-08 0.06090946528319695 0.020303147228769653 6.078811775698392e-11 10.216181303899834 -0.605708512244692 K(ub)ENCPACSQLPQNIQFSPSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KENCPACSQLPQNIQFSPSAK 21 1 F8W8D4;Q8TBC4-2;Q8TBC4 F8W8D4 UBA3 NEDD8-activating enzyme E1 catalytic subunit 1 18021200.0 4675700.0 6226400.0 7119100.0 True False 6129887.979543217 5297445.390317104 6382483.823229258 1.0 0.8641993798248586 1.041207252812614 22.547429278993224 -6.701751906899759 1.8247545701299162 0.9158166634819747 1.0406956400909304 0.425800592168907 0.05730520743213458 0.3919081808311997 2.5382373252643773 0.025042963088997807 0.06426179055390809 1.9872298090770635e-07 6.701751906899759 0.12487897660895575 K(ub)ENLK(ub)AAQEEYVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KENLKAAQEEYVK 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 2 38557000.0 10837000.0 15088000.0 12632000.0 True False 14207411.945657289 12836929.212563356 11324961.814700155 1.0 0.9035374818203367 0.797116452878091 23.760140438129216 -6.969860848830838 0.2614952482212611 1.0293376002489318 0.6681528353195104 0.999981269863821 0.00035855823542278964 0.07634794561035586 0.009191915307658288 0.002200293971732291 0.01001864178947577 1.0718626829680353e-07 6.969860848830838 -0.3611847649294214 K(ub)ENLK(ub)AAQEEYVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KENLKAAQEEYVK 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 2 88829000.0 19977000.0 23696000.0 45156000.0 True False 19342841.06985693 33157936.373007577 33328288.94903757 1.0 1.7142226549480113 1.7230296639812117 24.205296377142304 -11.197678292905422 0.7174118181198542 5.031219830483295e-16 1.7214196751453168 0.9999825863542157 0.0014137169209281538 3.745852906877588 0.3696986566735836 6.021506821495857 0.0013522849443344356 6.343394292435141e-12 11.197678292905422 1.7214196751453164 K(ub)ENLK(ub)AAQEEYVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KENLKAAQEEYVK 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 2 75288000.0 26765000.0 24852000.0 23671000.0 True False 40604461.78360072 20416966.430437718 18992416.474632137 1.0 0.5028256879563836 0.46774210617175993 25.27513492953824 -13.999999999999998 0.37642238069113726 8.21130879011572 0.4644648557072306 0.9998016886396109 0.003422866808823853 23.58934657269735 0.19973967006262794 137.6441579818187 0.009612583520796587 1.0000000000000041e-14 13.999999999999998 -7.7468439344084885 K(ub)ENLK(ub)AAQEEYVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KENLKAAQEEYVK 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 2 38756000.0 10837000.0 13828000.0 14091000.0 True False 14843731.758913277 13217033.236918977 10762996.013254503 1.0 0.8904117543745352 0.7250869382486383 23.823350499652108 -6.965162538012521 0.35526049816472877 1.0150400295050679 0.5948347106275078 0.9999164442142174 0.00103289524123449 0.07790594264281259 0.014666299068395568 0.0022407865425740966 0.014161916981442138 1.0835213220333954e-07 6.965162538012521 -0.4202053188775601 K(ub)ENLK(ub)AAQEEYVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KENLKAAQEEYVK 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 2 77371000.0 19977000.0 36628000.0 20766000.0 True False 16611760.631155385 36430677.693911284 25108074.58886437 1.0 2.1930654132822918 1.51146378438503 23.98570165257658 -10.109882173354586 4.861838461903453 0.9999599292941482 1.852264598830004 0.6758107042972155 0.27826269979390533 0.0001209046099001062 2.2136073519276983e-05 0.269439315708504 0.08980890017830587 7.764577456048074e-11 10.109882173354586 0.8523046695358557 K(ub)ENLK(ub)AAQEEYVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KENLKAAQEEYVK 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 2 65765000.0 26765000.0 28836000.0 10164000.0 True False 34647820.11702546 27231251.2511188 8314256.291446912 1.0 0.7859441419155182 0.239964773061189 25.04626125163069 -6.9702233433229 0.5056730785755682 1.0103097253630822 2.8641128709648583e-22 0.9995420470583042 0.006847821922051043 0.07907392149175865 0.028153865531505957 0.008021039735718046 0.043584356472087096 1.0709683998810727e-07 6.9702233433229 -1.0103097253630822 down K(ub)ENLK(ub)AAQEEYVKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KENLKAAQEEYVKR 14 3 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 2 5620200.0 1781600.0 1920400.0 1918200.0 True False 2335694.8530389396 1633883.8056605707 1719723.0646736757 1.0 0.69952793856387 0.7362789974196193 21.155420374893385 -10.231816681722382 8.17015240040799 1.0000001493560957 0.7179034681188089 0.9874306691428161 0.015003556950596492 4.0811252781906485e-08 3.841831305537632e-09 0.014527139343731914 0.004842377183627894 5.863856291354817e-11 10.231816681722382 -0.2820966812372868 K(ub)ENLK(ub)AAQEEYVKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KENLKAAQEEYVKR 14 3 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 2 13357500.0 2361500.0 3505200.0 7490800.0 True False 2286535.4751197444 4904844.639376526 5528734.760816959 1.0 2.1450988592773363 2.4179527590873797 21.124731871754555 -10.433058769285536 0.3077148996176367 3.315184798747681e-24 2.499445449327485 0.9990565519562938 0.018868620315879728 1.9615204477700356 0.14735077603405003 1.646799618287784 0.09463190113831632 3.6892767142710385e-11 10.433058769285536 2.499445449327485 K(ub)ENLK(ub)AAQEEYVKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KENLKAAQEEYVKR 14 3 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 2 32747000.0 5960000.0 10134000.0 16653000.0 True False 9041755.734364305 8325508.522696605 13361527.250730796 1.0 0.9207844988617073 1.4777580420524599 23.10817151268541 -6.870857901376341 1.129605757135201 0.9549614426223727 1.5109051706382786 0.9655289875916497 0.04567760582758447 0.13603190842400883 0.32390125933962727 0.03136659314089593 0.07437110965264387 1.346300783769981e-07 6.870857901376341 0.5559437280159059 K(ub)ENLK(ub)AAQEEYVKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KENLKAAQEEYVKR 14 3 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 2 6652400.0 1781600.0 2184900.0 2685900.0 True False 2440305.665929672 2088363.8935019001 2051545.7378468735 1.0 0.8557796355836046 0.840692117585731 21.218630436416277 -13.99999999975108 0.3189377894289838 2.4694549611683714 0.837661152609396 0.9996914390580508 0.0012613407710292991 17.931144446509524 0.18005415373166075 17.57170797844169 0.005044120134274574 1.0000000005731616e-14 13.99999999975108 -1.6317938085589754 K(ub)ENLK(ub)AAQEEYVKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KENLKAAQEEYVKR 14 3 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 2 9863000.0 2361500.0 5011300.0 2490200.0 True False 1963691.8821881884 4984303.132234827 3010889.306616103 1.0 2.538230756793016 1.5332799070600616 20.90513714718883 -10.529704836782692 5.240364829952456 0.9964458238938187 2.035755331926545 0.586148681008881 0.4102694664037086 0.0170629828975821 0.00153131247048939 0.39786743479235454 0.13241390090324381 2.953215663603192e-11 10.529704836782692 1.0393095080327261 K(ub)ENQWCEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KENQWCEEK 9 1 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 20578600.0 6971900.0 8775100.0 4831600.0 True False 9140228.41597564 7465889.285071889 4331672.379979843 1.0 0.8168164891834347 0.47391292458389567 23.12379878827029 -6.961318385741382 0.41643732746052964 1.0157509955679034 0.2621185101835428 0.9998160115332638 0.0029576565630018543 0.07923349127013254 0.01941575330135475 0.004426695756206762 0.028573097266084556 1.0931546695358357e-07 6.961318385741382 -0.7536324853843606 down K(ub)ENQWCEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KENQWCEEK 9 1 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 12825030.0 5896100.0 4961800.0 1967130.0 True False 5708931.5328619685 6943072.615445168 1451879.6403649624 1.0 1.2161772435838807 0.25431722766468606 22.444789329539063 -6.847675545337622 1.2461657283568819 1.115175868760141 0.21753772554563525 0.9368639663710295 0.103531373584836 0.16003515018114234 0.47940031781228687 0.06504502906252602 0.15031959920925392 1.4201180736357008e-07 6.847675545337622 -0.8976381432145057 down K(ub)ENQWCEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KENQWCEEK 9 1 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 17292300.0 4926100.0 5353400.0 7012800.0 True False 7473253.846149653 4398043.943694892 5626717.006180575 1.0 0.5885045569488904 0.7529139411047244 22.833305096891227 -10.28350845419285 5.166407791604175 1.000065447168195 0.6707092490267498 0.842486324196238 0.06711985001805008 5.0608064515348813e-05 7.0183822003589304e-06 0.06500139167454877 0.02166283844328983 5.205848747382649e-11 10.28350845419285 -0.3293561981414451 K(ub)ENQWCEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KENQWCEEK 9 1 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 20264000.0 6971900.0 7439300.0 5852800.0 True False 9549599.838513188 7110607.127524674 4470489.182199706 1.0 0.7445973912799837 0.46813366610089635 23.18700884979318 -6.97011285185158 0.2554758775346611 1.0820328129573507 0.12254398755239139 0.999983249113028 0.000888894233246814 0.07626610169031547 0.008899007752806463 0.005944340334586118 0.026265848498032953 1.0712409060568066e-07 6.97011285185158 -0.9594888254049593 down K(ub)ENQWCEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KENQWCEEK 9 1 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 13733430.0 5896100.0 4677200.0 3160130.0 True False 4902868.391518013 4652002.995248491 3820898.572209761 1.0 0.9488329328391681 0.7793190163578396 22.22519460497334 -6.949201552966013 0.5675451660401722 1.0021355661683171 0.7178094632735206 0.9991370967500448 0.0027704353659547265 0.0838080307502988 0.03730206767567926 0.0029433916540958305 0.014115444327568168 1.1240831739250232e-07 6.949201552966013 -0.28432610289479654 K(ub)ENQWCEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KENQWCEEK 9 1 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 14455000.0 4926100.0 2982600.0 6546300.0 True False 6376933.557948031 2816615.688083886 5354940.570710243 1.0 0.4416881033005801 0.8397359831413007 22.604431418983676 -9.85257576349061 5.739374663035829 1.0000000933136262 0.6407120432199871 0.5206846435398409 0.1625023664711571 1.939427215775843e-07 3.880830649375123e-08 0.15734227962168082 0.05244741325467569 1.404184699543188e-10 9.85257576349061 -0.35928805009363907 K(ub)ENSGAAEKPVTIHATPEGTSEACR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KENSGAAEKPVTIHATPEGTSEACR 25 2 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 10921600.0 3916800.0 4304900.0 2699900.0 True False 5134962.7303451495 3662625.7003687713 2420540.247269549 1.0 0.7132721097904806 0.47138418998940834 22.291922374798247 -7.076608000237842 0.1764537417235964 1.203069473065249 9.636224416883345e-11 0.999996726620537 0.00039087286289401065 0.0742642661406511 0.005946521079970335 0.01074865361594389 0.028268830068874717 8.382855880590406e-08 7.076608000237842 -1.2030694729688867 down K(ub)ENSGAAEKPVTIHATPEGTSEACR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KENSGAAEKPVTIHATPEGTSEACR 25 2 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 7606600.0 3283300.0 2960300.0 1363000.0 True False 2730209.4248522087 2944352.2763264533 1647996.9982000443 1.0 1.078434588030124 0.6036155993012343 21.380580188823703 -6.864476864263082 1.162839880287084 1.0431799768037642 0.578568982799148 0.958857285151854 0.0421547786604017 0.14226469194318 0.3630218566762332 0.028217428391558216 0.06623973846368753 1.3662278554461662e-07 6.864476864263082 -0.46461099400461614 K(ub)EPVDEDLYPEHYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEPVDEDLYPEHYR 14 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 28900700.0 11494000.0 13955000.0 3451700.0 True False 15068745.308054334 11872968.396163944 3094551.195044377 1.0 0.7879201720808018 0.20536223366854048 23.84505596082837 -7.02485248163759 0.5474378876779246 1.0070989189403228 7.665954447589047e-12 0.9993685056958715 0.008442433231764334 0.07466870629716126 0.03282513574402458 0.00939738759129528 0.04322771538220818 9.443816032937742e-08 7.02485248163759 -1.007098918932657 down K(ub)EPVDEDLYPEHYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEPVDEDLYPEHYR 14 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 22823300.0 11494000.0 8574800.0 2754500.0 True False 15743642.413670678 8195936.982928318 2103943.8307082215 1.0 0.5205870895423501 0.1336376789707383 23.90826602235126 -7.998884555643681 0.38142329416292037 1.0698709764174101 9.402984572684273e-23 0.9978959427646612 0.016254573799169142 0.0985300588174474 0.08113670356685232 0.04833232149851124 0.08337696948767098 1.0025717067261024e-08 7.998884555643681 -1.0698709764174101 down K(ub)EQDIYTHLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEQDIYTHLVK 11 1 A0A0A0MRG9;Q96SN8-4;Q96SN8-3;Q96SN8-2;Q96SN8;F8WCI3 A0A0A0MRG9 CDK5RAP2 CDK5 regulatory subunit-associated protein 2 1 6095700.0 1968200.0 1931700.0 2195800.0 True False 1905720.568338211 2703037.8836824247 1620654.1074120095 1.0 1.4183810200671103 0.8504153937034014 20.861905164843453 -6.709334019552982 1.7976886286583602 1.2573852646255876 0.8517811754313803 0.46191958893403084 0.1763215268475219 0.3763993919260536 2.3707828481813316 0.07806740459511115 0.1984800707798562 1.9528369346734613e-07 6.709334019552982 -0.4056040891942073 K(ub)EQDIYTHLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEQDIYTHLVK 11 1 A0A0A0MRG9;Q96SN8-4;Q96SN8-3;Q96SN8-2;Q96SN8;F8WCI3 A0A0A0MRG9 CDK5RAP2 CDK5 regulatory subunit-associated protein 2 1 5135700.0 1968200.0 1989500.0 1178000.0 True False 1636645.5060439534 1978782.1686151668 1424314.353543397 1.0 1.2090475068105708 0.8702644209045634 20.64231044027773 -6.739768583678005 1.6874434176299213 1.1244154871931342 0.8700720659611555 0.603935884235707 0.0878334781914619 0.3182402752932491 1.779181269744242 0.041178278455312044 0.10107738283914044 1.8206707551026977e-07 6.739768583678005 -0.25434342123197873 K(ub)ESKEEETSIDVAGKPNEVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KESKEEETSIDVAGKPNEVTK 21 3 P53985 P53985 SLC16A1 Monocarboxylate transporter 1 1 9065700.0 3584800.0 3236100.0 2244800.0 True False 4699707.515252581 2753286.4942189995 2012529.6296420943 1.0 0.5858420944885178 0.4282244422893481 22.164139543258102 -13.999999999999998 0.13391251059565704 2.9703782514314914 0.21808001964646168 0.9996282777614657 0.004649025882194634 11.932651767562366 0.11416767599769334 6.168496154303891 0.18720329118624413 1.0000000000000041e-14 13.999999999999998 -2.7522982317850295 K(ub)ESKEEETSIDVAGKPNEVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KESKEEETSIDVAGKPNEVTK 21 3 P53985 P53985 SLC16A1 Monocarboxylate transporter 1 1 14396300.0 6247600.0 4357400.0 3791300.0 True False 9478065.96074067 3579787.9254784067 3041947.89321418 1.0 0.3776918139530083 0.3209460564860286 23.176161270482737 -13.999999999999998 0.338896953536355 8.14941153473778 0.3119137909844492 0.9997329976442985 0.005026368155400543 19.60309011993245 0.1866699094742482 100.34775793000165 0.0176016912120782 1.0000000000000041e-14 13.999999999999998 -7.837497743753331 K(ub)ESKEEETSIDVAGKPNEVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KESKEEETSIDVAGKPNEVTK 21 3 P53985 P53985 SLC16A1 Monocarboxylate transporter 1 1 9775600.0 3584800.0 3109000.0 3081800.0 True False 4910197.4355774 2971634.099911853 2353942.3116633114 1.0 0.6051964587779173 0.47939870902289017 22.227349604780994 -13.999999999999998 0.16003721647169286 2.9445049857928267 0.35578408666666916 0.9995362691811668 0.004776131547874551 12.009944492428694 0.1264220507490358 7.2490429439275115 0.11266901298369073 1.0000000000000041e-14 13.999999999999998 -2.5887208991261574 K(ub)ESKEEETSIDVAGKPNEVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KESKEEETSIDVAGKPNEVTK 21 3 P53985 P53985 SLC16A1 Monocarboxylate transporter 1 1 7870800.0 1767400.0 5023500.0 1079900.0 True False 1469671.4090956615 4996437.408413323 1305702.0971065494 1.0 3.3996969509584454 0.8884313112616051 20.487062200944127 -6.656488022152387 1.9852652167869405 2.5491281595295514 0.8989490593012336 0.22073590312322477 1.0226067843605853 0.4928845096614727 3.7305169410842036 0.4166884354997782 1.1332795030946967 2.2055249639619045e-07 6.656488022152387 -1.6501791002283177 K(ub)ESYSVYVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KESYSVYVYK 10 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 23181600.0 7354000.0 9674700.0 6152900.0 True False 9641165.216237312 8231272.471685225 5516256.930784404 1.0 0.8537632420013304 0.5721566643722813 23.200776088196257 -6.960778677877843 0.42431850130512433 1.0118837833420538 0.40333762590530997 0.9997979929514145 0.0025235920059915734 0.07942415915102984 0.020112295389122303 0.0036539762924417806 0.023414580749676284 1.0945140027561515e-07 6.960778677877843 -0.6085461574367438 K(ub)ESYSVYVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KESYSVYVYK 10 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 34050800.0 8097300.0 8812500.0 17141000.0 True False 7840255.643737932 12331377.206580395 12651257.88102251 1.0 1.5728284595451367 1.6136282355955012 22.902469265748838 -11.483832641082937 0.43739191451935777 1.367660424795176e-20 1.614449230285226 0.9997471480009038 0.004454689675796204 3.9916432262200243 0.21700153170400896 3.7939303343520807 0.009474498381605275 3.28221751671865e-12 11.483832641082937 1.614449230285226 K(ub)ESYSVYVYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KESYSVYVYK 10 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 30506000.0 12631000.0 8687800.0 9187200.0 True False 19162150.44979118 7137394.211908783 7371345.893107185 1.0 0.3724735504300647 0.3846826019042927 24.19175613912482 -9.9749481639554 5.28156858768241 1.0000022037620773 0.378578076164489 0.9997105811297194 0.0049843244031837096 3001192.8925813837 5668152.132098225 55.39692435501513 0.0017062672371014169 1.0593801619674292e-10 9.9749481639554 -0.6214241275975882 K(ub)ESYSVYVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KESYSVYVYK 10 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 23238300.0 7354000.0 6634300.0 9250000.0 True False 10072972.534377435 6341174.6893037 7065340.509729911 1.0 0.629523675127902 0.7014156432589327 23.26398614971915 -10.804900571586531 7.170040089226493 1.013352567738965 0.6654696591934173 0.9665217586503665 0.02934977308757581 0.006213020468620598 0.00016905833673419167 0.028183841720553663 0.009472598531928982 1.567109806894657e-11 10.804900571586531 -0.3478829085455477 K(ub)ESYSVYVYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KESYSVYVYK 10 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 30483900.0 8097300.0 17517000.0 4869600.0 True False 6733263.721212125 17422632.44414773 5887810.845513526 1.0 2.5875464211004195 0.874436393596893 22.682874541183114 -6.663229902754339 1.9612411376017296 2.019137760448092 0.8815002195487335 0.24952278303619868 0.6754194280917162 0.4768192649408215 3.528980097883643 0.277896107876543 0.7491214494825855 2.1715513189955027e-07 6.663229902754339 -1.1376375408993584 K(ub)ESYSVYVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KESYSVYVYK 10 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 29609100.0 12631000.0 12026000.0 4952100.0 True False 16351078.494233096 11356742.52829638 4050868.612836905 1.0 0.6945561745240119 0.2477432063130035 23.96288246121727 -7.200735770546522 0.3981774003684075 1.0298253081865756 1.0095004948600006e-14 0.9996933722925461 0.005409253120880175 0.0886506566529279 0.0251583559886839 0.008932511867990947 0.04401157880808647 6.298892977517631e-08 7.200735770546522 -1.0298253081865656 down K(ub)ETEGDVTSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KETEGDVTSVK 11 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 2544410.0 642050.0 948100.0 954260.0 True False 841733.7676210455 806647.1756648554 855522.3291082794 1.0 0.9583162832407761 1.0163811433230294 19.683004469166985 -6.7140181503890375 1.7806801847925076 0.9744797674829336 1.016262689247518 0.48422910232813643 0.017554699752207834 0.3670690845959132 2.2711862255415003 0.007837718254438297 0.019816572606199914 1.9318875763092238e-07 6.7140181503890375 0.04178292176458431 K(ub)ETEGDVTSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KETEGDVTSVK 11 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 2272240.0 576370.0 885520.0 810350.0 True False 558073.449838987 1239112.753925794 598095.0250210951 1.0 2.2203399109620743 1.071713813286862 19.09009548671513 -6.631939972023649 2.0734303360351487 1.802871114718806 1.0763923622133054 0.1243738158894282 0.5232125019218278 0.5540978493009303 4.5421052525091525 0.20620758870227682 0.579535716845582 2.3337806140334584e-07 6.631939972023649 -0.7264787525055005 K(ub)ETEGDVTSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KETEGDVTSVK 11 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 4976100.0 1565600.0 0.0 3410500.0 True False 2375129.6606914 0.0 2736413.1801247504 1.0 0.0 1.1521110722553904 21.179574843075326 -10.687793912132435 4.493365945823165 1.0167668953897446 0.5760555361320993 0.15292838477489568 0.4703473756729019 0.07972361587224061 0.005539317100464124 0.4595644436828184 0.15180396274277153 2.0521357577462084e-11 10.687793912132435 -0.4407113592576454 K(ub)ETEGDVTSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KETEGDVTSVK 11 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 2690280.0 642050.0 896330.0 1151900.0 True False 879433.235748849 856727.1768330628 879844.9441251773 1.0 0.9741810316090093 1.000468151941037 19.746214530689876 -9.919861213831231 4.419551359352176 1.000000210396419 0.9873245917698704 0.23664737541355874 0.010731671953710454 642792442580.8805 157203649792.64886 1479241.7264875958 0.0036736038594930567 1.2026487000078845e-10 9.919861213831231 -0.012675618626548535 K(ub)ETEGDVTSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KETEGDVTSVK 11 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 2240210.0 576370.0 1195100.0 468740.0 True False 479277.1925203501 1188661.7590912243 566751.3667911135 1.0 2.4801133407589675 1.1825126996149504 18.870500762149405 -6.614419826001144 2.1380142052785 1.9859176241065375 1.187352080765217 0.06428005108840662 0.6374096310225006 0.6004093255456371 5.207435281164999 0.24568705537756316 0.7069393051737383 2.429853969774804e-07 6.614419826001144 -0.7985655433413206 K(ub)ETEGDVTSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KETEGDVTSVK 11 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 6311400.0 1565600.0 1648300.0 3097500.0 True False 2026700.0625897658 1556570.65602785 2533786.7830339223 1.0 0.7680320757669622 1.2502031404667688 20.950701165167775 -6.775910109932632 1.5520273715625887 0.8679543616607159 1.2535290826800347 0.7525683297312651 0.09793922528390672 0.25698576432169806 1.2224035582378534 0.04971956229691281 0.11771392773285573 1.675289590794427e-07 6.775910109932632 0.3855747210193188 K(ub)ETKPEPMEEDLPENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KETKPEPMEEDLPENK 16 2 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 4944200.0 1664300.0 2148400.0 1131500.0 True False 2181913.417104127 1827867.0943976098 1014423.2341144121 1.0 0.8377358515094455 0.4649236886130762 21.05716242295963 -6.957244732800659 0.47266749682536313 1.0095960202197753 0.27771121538080173 0.9996539643324688 0.0041670417853468325 0.08070045035510262 0.024882391110752473 0.0051809272093270384 0.030764763415238334 1.1034566268861422e-07 6.957244732800659 -0.7318848048389737 down K(ub)ETKPEPMEEDLPENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KETKPEPMEEDLPENK 16 2 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 5785700.0 2519800.0 1724900.0 1541000.0 True False 2439810.3282687874 2413661.5652346713 1137365.870990939 1.0 0.9892824607178909 0.4661697910746931 21.218337565840976 -6.9113286362413495 0.886640880003466 1.0155239358768995 0.3966098159966305 0.9914133148175877 0.023088461439245752 0.10354590405739686 0.13405100386899135 0.019027897420929578 0.05302175628403121 1.226510763381602e-07 6.9113286362413495 -0.618914119880269 down K(ub)ETKPEPMEEDLPENKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KETKPEPMEEDLPENKK 17 3 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 11304700.0 3155700.0 6021900.0 2127100.0 True False 4137153.2598422687 5123455.993182353 1907008.0965839718 1.0 1.238401304325305 0.46094693060915937 21.980206972176152 -6.824388304574725 1.3527163155463848 1.1279601897113904 0.4423138367515382 0.8941910856383742 0.10578493747520729 0.18784143887158206 0.674148640192492 0.06143215289410003 0.14145771727935216 1.4983445600666774e-07 6.824388304574725 -0.6856463529598522 down K(ub)ETKPEPMEEDLPENKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KETKPEPMEEDLPENKK 17 3 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 9611700.0 3497400.0 3494800.0 2619500.0 True False 3386376.9513799725 4890291.865141239 1933374.3666844699 1.0 1.444107355841886 0.5709270983245401 21.691311143744286 -6.76845184577976 1.580510986722519 1.2552316664865848 0.5663154474758222 0.724563474171624 0.18709427818624286 0.2689366510002781 1.3256216247674804 0.09332256442709165 0.2224515863889673 1.7043082811605726e-07 6.76845184577976 -0.6889162190107626 K(ub)ETKPEPMEEDLPENKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KETKPEPMEEDLPENKK 17 3 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 29322400.0 13716500.0 11037000.0 4568900.0 True False 20808933.310471103 9067361.117525406 3665854.912379987 1.0 0.43574367711403494 0.17616736320334692 24.310699676995696 -9.447164210854362 0.2366999438641318 1.4282486431817722 1.60470970883756e-20 0.9992036948007528 0.009704746447154832 0.8574474073942213 0.09299195064130622 0.39242080778531874 0.11878158741041815 3.571377754459596e-10 9.447164210854362 -1.4282486431817722 K(ub)ETKPEPMEEDLPENKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KETKPEPMEEDLPENKK 17 3 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 8294200.0 3155700.0 3466700.0 1671800.0 True False 4322447.5695859175 3313529.731156136 1276955.2718017797 1.0 0.7665864484907022 0.29542412053458633 22.043417033699043 -6.959863617353705 0.4373516149424316 1.0173195783437994 0.026401595606200323 0.9997651074954386 0.004491335119549323 0.07974987422266833 0.02131159715427778 0.00619217795625503 0.03905890716222726 1.0968225801660073e-07 6.959863617353705 -0.990917982737599 down K(ub)ETKPEPMEEDLPENKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KETKPEPMEEDLPENKK 17 3 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 11230500.0 3497400.0 6484500.0 1248600.0 True False 2908243.0610903995 6449566.711427529 1509676.4871258806 1.0 2.217684896326845 0.5191025837296596 21.471716419178563 -6.714283250719825 1.7799780228716433 1.7453031750883266 0.5225724091394074 0.48542542055408056 0.5127953640045663 0.36651728868739897 2.266191005989347 0.22903966536696913 0.5788572930451912 1.930708680932506e-07 6.714283250719825 -1.2227307659489193 K(ub)ETLVEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KETLVEDK 8 1 Q14172;A0A087WV90;A0A5H1ZRP8;A0A087WTU7;A0A075B6G3;P11532-3;P11532-2;P11532-4;P11532-11;P11532 Q14172 DMD Dystrophin 1 4750480.0 1949900.0 877380.0 1923200.0 True False 2670830.7240661597 838614.4504923311 1468979.7695473062 1.0 0.3139901166089617 0.5500085633697083 21.348857110894652 -10.182532003766235 5.35433385911132 1.0000238425262467 0.43199933998937484 0.8853508384420298 0.0963541274084889 2.7425086763607305e-05 4.187296385977948e-06 0.0932983907107466 0.031098160899216354 6.568527103001622e-11 10.182532003766235 -0.5680245025368718 K(ub)EVDATSPAPSTSSTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEVDATSPAPSTSSTVK 17 1 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 3271770.0 838820.0 1485200.0 947750.0 True False 1099701.143144435 1263613.9492642551 849685.9214599492 1.0 1.149052137611802 0.7726516670069072 20.068680076815486 -6.799253392274427 1.4588404380322348 1.0823168191150982 0.7675438023136448 0.8300057199091246 0.06381183867329238 0.22182365637804397 0.9320767486723911 0.03441166174020235 0.08006974284450587 1.5876201697784372e-07 6.799253392274427 -0.3147730168014534 K(ub)EVDATSPAPSTSSTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEVDATSPAPSTSSTVK 17 1 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 9087180.0 884780.0 1407700.0 6794700.0 True False 856693.1432040854 1969801.9510585219 5014964.233369329 1.0 2.2993086459071455 5.8538629299787 19.708419015935366 -6.953503468783179 0.5189598619223139 0.9391096776492613 7.372407488016503 0.999448308486836 0.048189157172403393 0.08210871684241068 0.03037085258678542 0.054682978978359546 0.29357845167045765 1.1130035030198379e-07 6.953503468783179 6.433297810367241 K(ub)EVDATSPAPSTSSTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEVDATSPAPSTSSTVK 17 1 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 3863320.0 838820.0 1429500.0 1595000.0 True False 1148954.4222581554 1366339.9632756477 1218293.8500561318 1.0 1.1892029281633667 1.0603500247309172 20.131890138338377 -10.381797641558927 4.95176066819809 0.999891621644267 1.124776476447165 0.5556156695226735 0.05260397754768468 6.29939167226119e-05 7.86448776679936e-06 0.05097774534236137 0.01697786074885925 4.151474344972633e-11 10.381797641558927 0.12488485480289802 K(ub)EVDATSPAPSTSSTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEVDATSPAPSTSSTVK 17 1 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 8065580.0 884780.0 2990300.0 4190500.0 True False 735733.772399943 2974190.660371919 5066714.175317161 1.0 4.042482174863595 6.886613562389125 19.488824291369642 -7.361116439050961 0.25870417068053175 1.2132218923397876e-16 9.903099462632678 0.9999005021368436 0.023976121512244153 0.12143982534965037 0.02094242019085664 0.1731679305363263 0.506756747195389 4.353951238903362e-08 7.361116439050961 9.903099462632678 K(ub)EWVTPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEWVTPK 7 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 3543090.0 707390.0 1338800.0 1496900.0 True False 927395.1403745039 1139056.2586015274 1342015.1472787103 1.0 1.2282318604144828 1.447080202228333 19.82282464133043 -6.971636373323816 0.21554772231974398 0.8932271671253205 1.7882328927474058 0.9999924870261925 0.0005002864223519565 0.0757752082712416 0.007098535104063623 0.0062738569623907075 0.02239574565110205 1.0674895362531568e-07 6.971636373323816 0.8950057256220854 K(ub)EWVTPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEWVTPK 7 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 3399000.0 968740.0 2063000.0 367260.0 True False 805550.2324586015 2051886.209526561 444052.3679816194 1.0 2.5471859194479354 0.5512410649132795 19.61961502967446 -6.6997757666211255 1.8318381825494068 1.9609514282853069 0.5572330509884523 0.41647341165278406 0.6531122784195431 0.39596911351510233 2.583120722803164 0.28446385221849724 0.7317226381942076 1.9962927676922745e-07 6.6997757666211255 -1.4037183772968547 K(ub)FAADAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFAADAVK 8 1 P37837 P37837 TALDO1 Transaldolase 1 5580000.0 1244300.0 2545100.0 1790600.0 True False 1631289.3498183412 2165381.000722099 1605325.8886480443 1.0 1.3274046084854498 0.9840840858961115 20.637581271989426 -6.656910266544204 1.9836738756223995 1.2112775673662548 0.9855162479030641 0.22263170366787144 0.1395045094674063 0.49180874369362126 3.7168364490682113 0.05688040777547612 0.15461773387998237 2.203381676361153e-07 6.656910266544204 -0.22576131946319067 K(ub)FAADAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFAADAVK 8 1 P37837 P37837 TALDO1 Transaldolase 1 3620100.0 1244300.0 1366000.0 1009800.0 True False 1704351.335943138 1305645.6032420688 771306.0374838122 1.0 0.7660659957294327 0.4525510798259175 20.700791333512317 -6.967061694560632 0.32070332397873663 1.0425829775044169 0.16591136549085017 0.9999495530575091 0.0015929668528859356 0.0772681438328237 0.012428910491348992 0.004738804116241406 0.02756038791347258 1.0787934612077585e-07 6.967061694560632 -0.8766716120135667 down K(ub)FAEAFEAIPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFAEAFEAIPR 11 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 22924200.0 5983200.0 9084200.0 7856800.0 True False 7844033.141391225 7728872.769934251 7043853.703747337 1.0 0.9853187296150882 0.8979887739864945 22.903164200318255 -6.93602074210027 0.6956242250295156 1.00107959278842 0.8769635795055641 0.9975944376717291 0.002208499909188278 0.08963034689614334 0.06323978860861738 0.0020897532008396394 0.00765732534274035 1.1587220137477267e-07 6.93602074210027 -0.12411601328285582 K(ub)FAEAFEAIPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFAEAFEAIPR 11 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 31592800.0 8802200.0 8349600.0 14441000.0 True False 8522778.97908069 11683638.822588777 10658468.879286291 1.0 1.3708719716029798 1.2505860946819916 23.02289248869953 -10.098062765559028 4.403053204340789 0.9999673424448207 1.3107290330790122 0.898965456249466 0.0491065036942908 34175813.875329114 0.8081069102985007 11502.509990460889 0.01681046235994613 7.978793669828323e-11 10.098062765559028 0.31076169063419157 K(ub)FAEAFEAIPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFAEAFEAIPR 11 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 72545000.0 20137000.0 28901000.0 23507000.0 True False 30549301.21189491 23743390.745456375 18860831.14651588 1.0 0.7772155107826645 0.6173899368661199 24.864636044266543 -7.155692370947411 0.09814771105287458 1.4194451941940867 3.4296860407068657e-10 0.9999995867404537 0.00010070028536664912 0.08466402656392251 0.003776254296335631 0.020214150237555586 0.033481252481487034 6.98727166673974e-08 7.155692370947411 -1.4194451938511181 K(ub)FAEAFEAIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFAEAFEAIPR 11 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 29738200.0 5983200.0 12394000.0 11361000.0 True False 8195350.729900335 11846392.09852284 8677765.787139628 1.0 1.4455015397085886 1.0588644797689042 22.966374261841146 -10.343732283468047 6.173956666431642 0.9999776155009645 1.2521830097387465 0.3619338110877456 0.15784391875035067 4.8638474563442245e-05 5.170037486839038e-06 0.15284526678927648 0.05094390571835201 4.5317685019894475e-11 10.343732283468047 0.252205394237782 K(ub)FAEAFEAIPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFAEAFEAIPR 11 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 28909200.0 8802200.0 13243000.0 6864000.0 True False 7319419.303576922 13171657.330470307 8299230.664449822 1.0 1.7995494975992778 1.1338646305444036 22.803297764133806 -10.216124317794007 4.50161033567851 0.9998713204392771 1.4667070639748758 0.39590740686339787 0.27176470903788874 0.0003768971195374701 6.562953789622237e-05 0.26321238378838147 0.08771168267145171 6.079609461493618e-11 10.216124317794007 0.46683574353559876 K(ub)FAEAFEAIPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFAEAFEAIPR 11 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 61653000.0 20137000.0 21068000.0 20448000.0 True False 26067743.459612973 19895547.279739574 16726673.814197816 1.0 0.7632247613056324 0.6416617472130883 24.635762366358993 -13.999999980846976 0.08520982357481675 2.2401632375243397 0.3112073936852026 0.9998643096472531 0.0017331894843043841 12.208022913828687 0.08360713934561792 2.7911604620286177 0.2983103759818156 1.0000000441014686e-14 13.999999980846976 -1.928955843839137 K(ub)FAEALGSTEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFAEALGSTEAK 12 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 1638250.0 0.0 722740.0 915510.0 True False 0.0 690806.9570184272 699285.3935203061 0.0 K(ub)FAEALGSTEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFAEALGSTEAK 12 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 2851770.0 780540.0 1590700.0 480530.0 True False 649053.5937849549 1582130.5833707731 581006.6012803125 1.0 2.4375962147356454 0.8951596707017268 19.307978084087217 -6.66199908216436 1.9654754820758253 1.9238557947838686 0.9015375524160258 0.24411937706139286 0.6118094582610415 0.4798233888129635 3.565251327572065 0.2512834921094661 0.678513770524951 2.1777143747182292e-07 6.66199908216436 -1.0223182423678427 K(ub)FAEALGSTEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFAEALGSTEAK 12 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 5893200.0 1295100.0 0.0 4598100.0 True False 1676532.4802376125 0.0 3761292.980490164 1.0 0.0 2.2434954436176993 20.67704900272358 -6.785544629866836 1.5141745668880144 0.4378417893222062 2.2644819647613192 0.786527138117285 0.424005871488598 0.24206578926502675 1.0964375082657705 0.22047618187893045 0.5178941858709432 1.6385336702501467e-07 6.785544629866836 1.826640175439113 K(ub)FAETQPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFAETQPK 8 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 6191800.0 1494500.0 2464700.0 2232600.0 True False 1959303.9727585868 2096976.367325354 2001591.9686114322 1.0 1.0702659702021287 1.0215831726168076 20.901909808671054 -10.58157807860423 4.741645453548962 0.9995235287394927 1.0459245714094711 0.5426538547143527 0.01987466888921646 0.00010114414476677781 8.925359649363063e-06 0.019442802493746546 0.0064145218016086235 2.620727834936241e-11 10.58157807860423 0.046401042669978465 K(ub)FAETQPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFAETQPK 8 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 6983300.0 2030500.0 2409200.0 2543600.0 True False 1966042.8889395061 3371206.123812024 1877354.8536356634 1.0 1.7147164707228082 0.9548900810848122 20.906863363528316 -6.659973499312094 1.9727758934745332 1.460069301527269 0.9580485675118395 0.2354925685135537 0.3043132299055103 0.4845640741694222 3.6251780584868936 0.12462106908576485 0.33738811919232026 2.1878951254314915e-07 6.659973499312094 -0.5020207340154295 K(ub)FAETQPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFAETQPK 8 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 3319920.0 632990.0 489130.0 2197800.0 True False 960292.1077676596 401840.92990986665 1763403.8666700383 1.0 0.41845697435127843 1.8363202742229447 19.873113795193344 -6.7953319852412255 1.4748250568360568 0.6772086036318591 1.8537227778947063 0.8181651855756301 0.24815436108864036 0.22750054299755207 0.9773326711851384 0.13239881552750649 0.30883695050698046 1.6020202993110228e-07 6.7953319852412255 1.1765141742628473 K(ub)FAETQPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFAETQPK 8 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 4016700.0 1494500.0 0.0 2522200.0 True False 2047057.037343903 0.0 1926508.3063395442 1.0 0.0 0.94111120071145 20.965119870193945 -10.036873474015465 13.369668301598209 0.9999999949887912 0.47055582392266937 0.2967579685218422 0.38420703882688634 0.0 0.0 0.3720068629464409 0.12400228857270265 9.186001795822122e-11 10.036873474015465 -0.5294441710661218 K(ub)FAETQPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFAETQPK 8 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 5926000.0 2030500.0 2726700.0 1168800.0 True False 1688450.7164019134 2712010.725892425 1413190.6760793915 1.0 1.6062125471282436 0.8369747854357865 20.687268638962593 -6.696567023693296 1.8428872717135052 1.3776840974159228 0.8393860955195912 0.40143153245566154 0.25605280764943233 0.40269212938868315 2.6563571152317946 0.11094149600046047 0.28655140079416747 2.0110968061911405e-07 6.696567023693296 -0.5382980018963316 K(ub)FAYLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFAYLGR 7 1 P40429;M0QYS1;Q8J015 P40429 RPL13A;RPL13a 60S ribosomal protein L13a 1 8820800.0 2138000.0 3041900.0 3640900.0 True False 2070130.360282033 4256546.533298935 2687239.0653412784 1.0 2.056173183566578 1.2981013741449456 20.981290189324483 -10.02695234986707 4.404321918896634 0.9999669496289493 1.6771372780537224 0.5154635394944935 0.3094815205742396 31158669.395193506 11822725.751841092 10155.736493233877 0.10594375757133395 9.398264212397799e-11 10.02695234986707 0.6771703284247731 K(ub)FEQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFEQLK 6 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 20954000.0 6190900.0 9962300.0 4800800.0 True False 8116329.852760879 8475963.672741244 4304059.268525373 1.0 1.0443099068796509 0.5302962480093498 22.95239606764598 -6.885921034262638 1.046188517595326 1.0303790437831475 0.48946048279621845 0.9781573520933992 0.03437197181520367 0.12251601360755401 0.24166878318011706 0.025157361397258087 0.061865238832193914 1.3004060032888905e-07 6.885921034262638 -0.540918560986929 K(ub)FEQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFEQLK 6 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 22247200.0 7524600.0 11026000.0 3696600.0 True False 7285735.691757798 15428739.299830422 2728349.564377098 1.0 2.1176638781015122 0.37447825172461624 22.796643227991638 -6.73355845777872 1.7103607182891543 1.6699359667883262 0.37484560180115944 0.5756157665404464 0.4697228312108243 0.3296178009787795 1.8906141212382583 0.2175006345620119 0.5375307205354417 1.8468921790845696e-07 6.73355845777872 -1.2950903649871668 K(ub)FEQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFEQLK 6 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 17608500.0 6190900.0 6578700.0 4838900.0 True False 8479843.032781778 6288031.281148317 3696051.480273743 1.0 0.7415268486503522 0.4358631953428115 23.015606129168873 -6.968907088074824 0.2830739818397914 1.0648949875312417 0.10314147322164915 0.9999725585385427 0.0012078510176024488 0.07665893352525194 0.010293600739878325 0.0055478540503165 0.02794887116020624 1.0742192036530713e-07 6.968907088074824 -0.9617535143095925 down K(ub)FEQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFEQLK 6 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 23596700.0 7524600.0 13547000.0 2525100.0 True False 6257038.2963003395 13474019.622131024 3053086.7352567343 1.0 2.1534181163791084 0.487944390089791 22.577048503425914 -6.7204141276463645 1.7578452274579195 1.7014112388810307 0.4904802972757709 0.5144784791863513 0.48533722717841915 0.35450473226503215 2.141049775051604 0.21920779379002844 0.5500215066619337 1.9036446049704018e-07 6.7204141276463645 -1.2109309416052598 K(ub)FEQLK(ub)QER ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFEQLKQER 9 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 2 6302500.0 2365500.0 2614900.0 1322100.0 True False 2290408.497309233 3659043.206523355 975802.3478501769 1.0 1.5975504853487887 0.42603856429826703 21.127173497115656 -6.768046494455722 1.5818612988627825 1.3435990988461552 0.4199202969426697 0.7230390559093527 0.25171534821286523 0.2696094081991908 1.3311128301983508 0.12544728239535213 0.29916347605371046 1.7058997499656243e-07 6.768046494455722 -0.9236788019034856 K(ub)FEQMK(ub)QDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFEQMKQDR 9 2 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;H0YAW6 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 2 6497600.0 2013000.0 3029200.0 1455400.0 True False 2639062.493919732 2577255.167729119 1304809.1691826 1.0 0.9765798171384671 0.494421474364027 21.3315940839143 -6.917013049489484 0.8465806700319575 1.0118263808204628 0.4217701312780903 0.9933102243874824 0.0190579729342642 0.09996147498683552 0.11495553715784655 0.016165760452933473 0.047124026193388395 1.210561758576972e-07 6.917013049489484 -0.5900562495423725 down K(ub)FEQMK(ub)QDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFEQMKQDR 9 2 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;H0YAW6 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 2 8502500.0 3752500.0 3477600.0 1272400.0 True False 3633378.941514647 4866223.815444427 939120.2688182172 1.0 1.339310843645679 0.2584702239801957 21.79288040811204 -6.822329803220408 1.3618157887540387 1.1824654860398554 0.233683730998061 0.8896509983026373 0.14992346641844964 0.19046851707177104 0.6934450466081302 0.08649921660873643 0.19924853316649285 1.505463383123828e-07 6.822329803220408 -0.9487817550417943 down K(ub)FEQMK(ub)QDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFEQMKQDR 9 2 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;H0YAW6 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 2 7852300.0 2876600.0 3524700.0 1451000.0 True False 4364012.507629589 2895689.746393202 1164209.214004109 1.0 0.6635383700964828 0.26677494896468 22.05722380587784 -7.313805631271543 0.34399440297146955 1.053123148606202 6.733767174064491e-24 0.9997259957176617 0.004960541347132164 0.10504344214229973 0.026334491705204795 0.012708767308638257 0.05133843562799331 4.8550573990007234e-08 7.313805631271543 -1.053123148606202 down K(ub)FEQMK(ub)QDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFEQMKQDR 9 2 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;H0YAW6 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 2 6100700.0 2013000.0 2682100.0 1405600.0 True False 2757260.499279546 2563595.9534813697 1073626.229240687 1.0 0.9297619699521392 0.38938150005094496 21.394804145437192 -6.93083047586745 0.7399451947021276 1.0079695832365825 0.2760616281002614 0.9966989245450102 0.015673962884518704 0.09220895342260194 0.07558488574931718 0.0143509044191902 0.048673765263635614 1.1726530139860212e-07 6.93083047586745 -0.731907955136321 down K(ub)FEQMK(ub)QDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFEQMKQDR 9 2 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;H0YAW6 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 2 8237600.0 3752500.0 3171100.0 1314000.0 True False 3120370.013936555 3154016.6548859333 1588751.3247504456 1.0 1.010782901001837 0.5091547853794844 21.573285683546317 -6.901988086058381 0.9486075546213876 1.0197334930424502 0.45432063757774693 0.9875298826511429 0.02612731225814405 0.10995685857688951 0.16927877357829627 0.02057731348172372 0.054093331010428146 1.2531755526648428e-07 6.901988086058381 -0.5654128554647033 K(ub)FFSASSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFFSASSR 8 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;V9GYI8 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 22103200.0 5858400.0 11143000.0 5101800.0 True False 7680419.132826311 9480507.835073804 4573914.675921252 1.0 1.2343737589207688 0.595529305994802 22.87275361260791 -6.807401798667817 1.4253730301947531 1.1281298531810016 0.5849994095743861 0.852947736445573 0.10118754678285469 0.21036557947547743 0.842828214823833 0.05582716194003361 0.12930158556961774 1.5581103101123475e-07 6.807401798667817 -0.5431304436066154 K(ub)FFSASSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFFSASSR 8 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;V9GYI8 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 33489400.0 9026400.0 11706000.0 12757000.0 True False 8739861.872801566 16380266.84598356 9415558.998203393 1.0 1.8742020279472515 1.077312105755881 23.059179048478093 -10.229791774307152 5.0986054355362 0.9999437238926968 1.4757570668517135 0.32214398031359426 0.32532894842333876 0.00020817274812463907 3.144727699326454e-05 0.31503552818737807 0.10499946660677761 5.891260484819781e-11 10.229791774307152 0.47581334295901667 K(ub)FFSASSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFFSASSR 8 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;V9GYI8 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 18534400.0 6886800.0 5877300.0 5770300.0 True False 10447779.092520136 4828449.895445509 4629797.675787671 1.0 0.46215084112013183 0.4431370183833878 23.316692962236946 K(ub)FFSASSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFFSASSR 8 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;V9GYI8 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 16319800.0 5858400.0 5716900.0 4744500.0 True False 8024408.797307151 5464308.454739805 3623946.8160447124 1.0 0.6809608773388427 0.45161542832424545 22.9359636741308 -7.798583127336232 0.15558942878560825 1.3173851974950237 1.2188344419273825e-11 0.999961171001108 0.0014012376280035865 0.1285852890773013 0.021284155266280767 0.06725979047991472 0.09514708536253706 1.5900723025069478e-08 7.798583127336232 -1.3173851974828354 down K(ub)FFSASSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFFSASSR 8 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;V9GYI8 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 38888200.0 9026400.0 26283000.0 3578800.0 True False 7505851.537320981 26141408.26223297 4327110.533498393 1.0 3.482803800774811 0.5764982843029751 22.83958432391237 -6.680496082859296 1.8998481787937678 2.570246702727928 0.5874787173459591 0.3263465229429061 1.0521683253603413 0.4375255989864595 3.0536103817712146 0.4442866256490111 1.1711506770902018 2.0869109468266445e-07 6.680496082859296 -1.9827679853819689 K(ub)FFTGSLAEVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFFTGSLAEVEK 12 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 21394300.0 6313900.0 7974100.0 7106300.0 True False 8277584.04389457 6784395.362798357 6371008.244442985 1.0 0.8196105683520583 0.7696700161132344 22.980778322979596 -13.999999985422248 0.18019146483625118 1.9365077703554014 0.7300779605094599 0.9994979054175912 0.0022167884132744675 12.207237407030123 0.13456813605731938 4.002708502315614 0.03722687569098981 1.0000000335665157e-14 13.999999985422248 -1.2064298098459414 K(ub)FFTGSLAEVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFFTGSLAEVEK 12 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 28804300.0 7465800.0 11645900.0 9692600.0 True False 7228802.265572299 16296168.602566214 7153817.288232822 1.0 2.2543386862548327 0.9896269154163202 22.78532519732161 -6.648113691293444 2.0159614589741897 1.815172781970891 0.9950059789329369 0.18625576647667674 0.5356185655763924 0.5131031657489494 3.99511245839574 0.21567393357274017 0.5929680478832494 2.2484659166584132e-07 6.648113691293444 -0.8201668030379541 K(ub)FFTGSLAEVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFFTGSLAEVEK 12 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 49089100.0 19503100.0 12157000.0 17429000.0 True False 29587628.56759736 9987488.366925474 13984150.510597939 1.0 0.33755623043960975 0.4726350568667258 24.818490734150966 -9.868260446354217 6.6854419623591985 1.0000000161535556 0.40509564365651035 0.9627723900729668 0.05514569996681358 1.3303342403126634e-08 2.1421989916746984e-09 0.053394595987849694 0.017798198132190052 1.3543769490472282e-10 9.868260446354217 -0.5949043724970453 K(ub)FFTGSLAEVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFFTGSLAEVEK 12 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 23822300.0 6313900.0 11529900.0 5978500.0 True False 8648319.456731793 11020470.893719409 4566501.43107246 1.0 1.2742904501684602 0.5280218259650349 23.043988384502487 -6.807235252767739 1.4262615519087176 1.1499835982850652 0.5157937143854525 0.8524371644633351 0.11839376679546444 0.21060487147944462 0.8448972436951573 0.06528254208898253 0.15120028572708066 1.558707938352907e-07 6.807235252767739 -0.6341898838996127 K(ub)FFTGSLAEVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFFTGSLAEVEK 12 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 22346700.0 7465800.0 10487200.0 4393700.0 True False 6208143.491018663 10430703.37205377 5312402.355826502 1.0 1.6801646719577108 0.8557151366607373 22.565730472755888 -6.687546509363709 1.8749118295100569 1.4273878622043454 0.8586273858716053 0.3590844544234987 0.28780525322772865 0.42195343833388677 2.8738261536098606 0.12288303553089625 0.32101537289921533 2.0533051226074893e-07 6.687546509363709 -0.5687604763327402 K(ub)FFTGSLAEVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFFTGSLAEVEK 12 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 51978800.0 19503100.0 17970200.0 14505500.0 True False 25247147.413575914 16970142.57292462 11865647.83899875 1.0 0.6721607908780786 0.4699797424487784 24.589617056243416 -9.085254219988919 0.12083205927044936 1.5866820079958526 2.7018842365061136e-12 0.9999243815449272 0.0018991512268610917 0.5456021925754424 0.04026488283221389 0.3065444226327913 0.197118108809793 8.217614802370716e-10 9.085254219988919 -1.5866820079931507 K(ub)FGDPVVQSDMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFGDPVVQSDMK 12 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 6821900.0 2811000.0 2185600.0 1825300.0 True False 2721766.343663609 3058321.4777534273 1347199.1721737576 1.0 1.1236532058945226 0.4949723826624927 21.376111789984336 -6.855632832302898 1.2075625264589747 1.0664567286996531 0.46696610741122396 0.9481138415260377 0.06194488886404815 0.15136708441059582 0.42192416991837184 0.04007391828471403 0.09313386010682667 1.3943351243070824e-07 6.855632832302898 -0.5994906212884292 down K(ub)FGDPVVQSDMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFGDPVVQSDMK 12 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 30875700.0 5244000.0 5298700.0 20333000.0 True False 7955531.387752739 4353105.586067939 16314173.637729526 1.0 0.5471797387122866 2.050670513706303 22.923526867557637 -6.825946424393513 1.3459730222923232 0.7572895777336256 2.087867338051176 0.8975170843944484 0.20160647555804306 0.18586300671804093 0.6599469798804273 0.11765331018423142 0.2708368614522776 1.4929785756287354e-07 6.825946424393513 1.3305777603175506 up K(ub)FGDPVVQSDMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 KFGDPVVQSDMK 12 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 38673800.0 5244000.0 13519600.0 19910200.0 True False 6788461.374693869 12767222.37531647 16286747.895903813 1.0 1.8807240213386673 2.3991810510431426 22.694653189650086 -8.958945211309246 0.16424779373854775 7.89917721602244e-20 3.170433457365347 0.9997854414532594 0.008459991468855736 0.4447639230843142 0.05304359000293836 0.5745010123446009 0.35041495266843514 1.0991444939442703e-09 8.958945211309246 3.170433457365347 K(ub)FGLTTSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFGLTTSR 8 1 P33992;B1AHB1;B1AHB2 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 3591660.0 1577600.0 1216600.0 797460.0 True False 1527519.9515345795 1702394.7244851873 588581.3027128062 1.0 1.1144828077531326 0.3853182422406363 20.54275979309454 -6.866768175920597 1.1511416393802154 1.0636324090804081 0.3451731445730323 0.961345183933439 0.06294948808712851 0.13998656831140477 0.3487392968394421 0.04251954068895345 0.10013321791601652 1.359038700615505e-07 6.866768175920597 -0.7184592645073758 down K(ub)FGLTTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFGLTTSR 8 1 P33992;B1AHB1;B1AHB2 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 3112950.0 1528900.0 1209100.0 374950.0 True False 2094175.6469689482 1155677.9640409828 286394.5323376464 1.0 0.5518534062382394 0.1367576462615091 20.997951021327232 -7.832518561479341 0.40409673115242656 1.0503729563526387 7.85204495925231e-26 0.9978018184920961 0.016527034811931785 0.11089371039021982 0.07560341244511949 0.03565266363070111 0.07955191663677219 1.4705555634201215e-08 7.832518561479341 -1.0503729563526387 down K(ub)FGVVLDEIKPSSAPELQAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFGVVLDEIKPSSAPELQAVR 21 2 M0QXB4;O14579-2;O14579;O14579-3;M0R061 M0QXB4 COPE Coatomer subunit epsilon 1 44090700.0 5460700.0 10679000.0 27951000.0 True False 8284281.130644816 8773249.01459218 22426472.598641478 1.0 1.0590235744340686 2.707111485591978 22.98194508219032 -6.91448749685131 0.8646065344968061 0.955925063930046 2.9418899827881266 0.9925079064316749 0.06848337946885641 0.10152504419116525 0.1232206401297172 0.05734328984490368 0.1636783012914477 1.2176220471482527e-07 6.91448749685131 1.9859649188580808 up K(ub)FGVVLDEIKPSSAPELQAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFGVVLDEIKPSSAPELQAVR 21 2 M0QXB4;O14579-2;O14579;O14579-3;M0R061 M0QXB4 COPE Coatomer subunit epsilon 1 9219300.0 1981000.0 3012300.0 4226000.0 True False 2713429.2345120623 2879206.6256559915 3227905.837202013 1.0 1.0610951592307658 1.1896038400951576 21.37168585340534 -6.95904690801565 0.4486651607253476 0.9957988563316204 1.259983278214905 0.9997331928257362 0.0012907098393091828 0.0800433607557294 0.022402757335870955 0.0017142749837576578 0.010631929645362373 1.0988871425544901e-07 6.95904690801565 0.2641844218832846 K(ub)FHEAQLSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFHEAQLSEK 10 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 19768100.0 4286900.0 7357800.0 8123400.0 True False 5620167.414398653 6260044.920479761 7282868.493155109 1.0 1.1138538158919904 1.2958454715239762 22.422181675628977 -6.96417902196372 0.37187272270200655 0.9862984903496383 1.4297543423051742 0.9998952073663397 0.0012472572080689116 0.07824065905517438 0.015849008189063794 0.002392176454199968 0.015441056696827311 1.0859778768100741e-07 6.96417902196372 0.44345585195553583 K(ub)FHEAQLSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFHEAQLSEK 10 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 24316700.0 7513100.0 8634600.0 8169000.0 True False 7274600.752963009 12082440.808844142 6029293.835253068 1.0 1.6609077555112364 0.8288143968309578 22.79443664105287 -6.695036177238363 1.8482678430161827 1.412363187089933 0.8314800983341698 0.3942445989867065 0.2792365169252285 0.40591329818948474 2.6921210045758714 0.12068324927727897 0.3123164256530039 2.0181982384050763e-07 6.695036177238363 -0.5808830887557631 K(ub)FHEAQLSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFHEAQLSEK 10 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 32286400.0 11762000.0 9088400.0 11436000.0 True False 17843813.91738137 7466504.012006698 9175669.587423133 1.0 0.4184365543474816 0.514221322297318 24.088920672497817 -10.829277643617699 7.399859421656796 1.0291039687883945 0.4663289383224108 0.9764094088535645 0.039103967767998515 0.01589242803127756 0.0003666541938527635 0.03204780922224736 0.01262075132800749 1.4815706171067112e-11 10.829277643617699 -0.5627750304659838 K(ub)FHEAQLSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFHEAQLSEK 10 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 17257100.0 4286900.0 6763500.0 6206700.0 True False 5871882.779116481 6464666.206096428 4740805.2909989925 1.0 1.1009528713836385 0.8073739666363576 22.48539173715187 -6.8138540542308 1.3981182878832774 1.0547733828799453 0.8017645340058389 0.8696944551891707 0.043961871228660444 0.2015865373027641 0.7758447821782379 0.024718289423787308 0.05708943193109075 1.535132781416409e-07 6.8138540542308 -0.25300884887410635 K(ub)FHEAQLSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFHEAQLSEK 10 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 22693300.0 7513100.0 10544000.0 4636200.0 True False 6247475.536763952 10487197.379179876 5605607.984633194 1.0 1.6786296028638796 0.8972596933987788 22.574841916487145 -6.677045325836137 1.9121403595763995 1.4305011279101694 0.9002799477085336 0.31077597998437434 0.287805335236719 0.44511183042701774 3.143828413156618 0.12088244087111684 0.3200599250780075 2.1035588870320728e-07 6.677045325836137 -0.5302211802016358 K(ub)FHEAQLSEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFHEAQLSEK 10 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 27936500.0 11762000.0 6190400.0 9984100.0 True False 15226140.863682196 5845898.798201056 8167096.245517038 1.0 0.3839383104713587 0.536386489435246 23.860046994590267 -10.322465999430765 8.669311990991096 1.0000007219539484 0.46016239995391994 0.9435646588410942 0.06223670844633605 8.684661425918815e-07 6.784380518482587e-08 0.06026051463685983 0.020086811277952175 4.759200489320889e-11 10.322465999430765 -0.5398383220000285 K(ub)FLDGIYVSEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFLDGIYVSEK 11 1 P32969;D6RAN4;A0A2R8Y5Y7;H0Y9V9;H0Y9R4 P32969 RPL9 60S ribosomal protein L9 1 9331000.0 2872500.0 3067000.0 3391500.0 True False 3718507.875440149 2896318.7538903225 2774281.799728672 1.0 0.7788927308772994 0.74607393413152 21.826292396961808 -13.999999999999998 0.2686269013667966 2.6940745031632716 0.7350343983611369 0.9995803822293318 0.002309940189507974 14.816185893616524 0.164059457711722 13.695918251554303 0.01372455084712648 1.0000000000000041e-14 13.999999999999998 -1.9590401048021346 K(ub)FLEHLSGAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFLEHLSGAGK 11 1 Q01813 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 1 6373300.0 1931300.0 2140200.0 2301800.0 True False 1869991.9386401728 2994793.020995561 1698889.5274801722 1.0 1.6015004980039245 0.9085009899644683 20.834600620127507 -6.6771866076631925 1.9116563726340365 1.3815302246062486 0.9111802307071845 0.3113671241674384 0.2550880890644046 0.44482072032529335 3.1403127930769665 0.10716316003499005 0.28368198612787116 2.1028746823741797e-07 6.6771866076631925 -0.4703499938990642 K(ub)FLPGPGTEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFLPGPGTEER 11 1 Q9BU02;G3V5B9;G3V5Q5;Q9BU02-2 Q9BU02 THTPA Thiamine-triphosphatase 1 2709330.0 1031800.0 772190.0 905340.0 True False 1352699.7919654143 656982.2619730448 811664.1014345032 1.0 0.4856822377554136 0.6000326948045067 20.36741026325827 -9.803893814469987 6.356378841934218 1.0000000114063743 0.5428574662798545 0.9551753483713015 0.046683378604691565 7.522870126645975e-09 1.4834957392899415e-09 0.04520098764343065 0.015066995656628246 1.5707468068953328e-10 9.803893814469987 -0.45714254512651975 K(ub)FLQEFYQDDELGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFLQEFYQDDELGK 14 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 13780500.0 3404900.0 4441400.0 5934200.0 True False 4463856.873098506 3778760.4324416 5320185.908865878 1.0 0.8465236542897133 1.1918361318724289 22.0898593393718 -6.785879250122474 1.512662651453116 0.9137586130416385 1.1951072250996104 0.7877044191033039 0.0650876385141469 0.24156293621588812 1.0919510629246816 0.03387620949423416 0.07956027015998626 1.6372716800393759e-07 6.785879250122474 0.2813486120579719 K(ub)FLQEFYQDDELGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFLQEFYQDDELGK 14 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 17025700.0 4646600.0 6883700.0 5495400.0 True False 4499096.22642025 9632397.308021266 4055989.881533815 1.0 2.1409627230145682 0.9015121431979247 22.101203792852534 -6.664665541617497 1.9560005680035883 1.7315587317622767 0.9065853944404868 0.2558129182961695 0.4852544014749061 0.47344693608348276 3.4867215001031866 0.20007981774574535 0.5383646958409173 2.1643847156073333e-07 6.664665541617497 -0.8249733373217899 K(ub)FLQEFYQDDELGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFLQEFYQDDELGK 14 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 14098000.0 4646600.0 5818100.0 3633300.0 True False 3863853.7792825107 5786756.740497568 4393006.231518874 1.0 1.4976645264180068 1.13694939882912 21.88160906828681 -10.301441593694372 9.717375721612076 0.9999999483197975 1.3173069626235634 0.5078104399219856 0.1472613341826173 1.6479476094645e-07 1.180699522517164e-08 0.14258519707873438 0.04752839123579685 4.995263547370702e-11 10.301441593694372 0.31730701430376584 K(ub)FLQEFYQDDELGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFLQEFYQDDELGK 14 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 31079000.0 7924500.0 5166500.0 17988000.0 True False 10258421.465248218 4878979.733281502 14714368.572466278 1.0 0.47560726080612903 1.4343696661628869 23.290305414701855 -6.758176666616801 1.6191595331853557 0.6947168048630407 1.4375814621368244 0.6835504792880263 0.2205082285397973 0.28599006559373796 1.477278113870848 0.10747050218209442 0.2587535982459373 1.7451121144976223e-07 6.758176666616801 0.7428646572737837 K(ub)FLQEFYQDDELGKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFLQEFYQDDELGKK 15 2 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 11532200.0 2347700.0 5296900.0 3887600.0 True False 3077857.4351591393 4506623.1671544835 3485348.4444924295 1.0 1.4642078985446805 1.1323943743067557 21.553494977613987 -10.422040126248364 9.685380649159006 0.9999992468323732 1.2983011364257182 0.5186770055912637 0.13546230402292236 2.2031171644163016e-06 1.3136833297305692e-07 0.13116114214543662 0.04372027062663871 3.784076204698471e-11 10.422040126248364 0.298301889593345 K(ub)FLQEFYQDDELGKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFLQEFYQDDELGKK 15 2 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 14791200.0 3311200.0 5629300.0 5850700.0 True False 3206087.768459246 7877108.84641169 4318226.152762292 1.0 2.4569223974168377 1.3468833246687777 21.61238248994692 -10.352804955372825 5.4820537915209036 0.9997446114157238 1.9019028610428195 0.4681418989370868 0.45317155379753377 0.0014149070341809896 0.00016703862699530392 0.4389010915552863 0.14626049006939218 4.4380791635654183e-11 10.352804955372825 0.9021582496270957 K(ub)FLQEFYQDDELGKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFLQEFYQDDELGKK 15 2 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 85341000.0 15579000.0 18540000.0 51222000.0 True False 23634481.977459975 15231392.146318829 41097949.24859989 1.0 0.6444563566421676 1.738897822587975 24.494389908144836 -6.819228425929299 1.3751780396523072 0.8082125091524076 1.762403601932922 0.882605970742053 0.1561866277364658 0.194486284396091 0.7229025057910805 0.08925476271654782 0.20576453424306076 1.5162526540707992e-07 6.819228425929299 0.9541910927805143 K(ub)FLQEFYQDDELGKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFLQEFYQDDELGKK 15 2 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 10680000.0 2347700.0 5195600.0 3136700.0 True False 3215708.134206946 4966041.212448376 2395876.0623643068 1.0 1.5443071961731674 0.745053954641681 21.61670503913688 -6.72334347691417 1.747350525578368 1.3299600342283242 0.7460630083528741 0.5282427877105383 0.22895703423631583 0.3488482463607548 2.0833289633001155 0.10397104543540928 0.2599789494687531 1.8908475844716484e-07 6.72334347691417 -0.5838970258754501 K(ub)FLQEFYQDDELGKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFLQEFYQDDELGKK 15 2 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 13744700.0 3311200.0 7072800.0 3360700.0 True False 2753409.511031776 7034697.422559116 4063406.8318788554 1.0 2.5549041631380964 1.47577278846407 21.392787765381197 -10.465357753566463 5.616410913013218 0.9989911186172519 2.015338475801078 0.5413585997765735 0.44055353889659576 0.00557001482286759 0.0005302249231228562 0.4269146676067938 0.1421880432716038 3.4248554509545536e-11 10.465357753566463 1.0163473571838262 K(ub)FLQEFYQDDELGKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFLQEFYQDDELGKK 15 2 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 88927000.0 15579000.0 10812000.0 62536000.0 True False 20167322.60800075 10210302.69548816 51155089.6735463 1.0 0.5062795341726494 2.5365335135389824 24.265516230237285 -6.842450455074841 1.271065682347235 0.7373902833436052 2.6065721295205115 0.9285705572377535 0.23105534981325399 0.16595682932354525 0.519780817054959 0.14248313503363966 0.32848257877476894 1.4373070140089432e-07 6.842450455074841 1.8691818461769063 up K(ub)FMNPFNMPNLYQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFMNPFNMPNLYQK 14 1 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 16951700.0 8123500.0 7235900.0 1592300.0 True False 7865623.939079081 10125232.604720002 1175228.8620239275 1.0 1.2872764682296112 0.14941330416077903 22.907129781006077 -6.839789887400307 1.2832581480977465 1.15283668352343 0.11211850961671167 0.9241050661278459 0.13309849945675387 0.1690487887956778 0.5408319662510284 0.08132906223840722 0.18736767374676708 1.446139246790477e-07 6.839789887400307 -1.0407181739067184 down K(ub)FMNPFNMPNLYQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFMNPFNMPNLYQK 14 1 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 37655700.0 13482000.0 18142000.0 6031700.0 True False 20453179.666224718 14904418.355907025 4839531.85121198 1.0 0.7287091102279506 0.23661513418393929 24.285821807236946 -7.109871029634271 0.4468989325859908 1.017621908653801 3.0063987000117e-17 0.9996797364477651 0.0056544991224721 0.07725056856473557 0.024631131015532975 0.007595950825244904 0.03984842172741354 7.764776692725622e-08 7.109871029634271 -1.017621908653801 down K(ub)FMNPFNMPNLYQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFMNPFNMPNLYQK 14 1 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 36114300.0 13482000.0 17821000.0 4811300.0 True False 17452714.76995094 16829245.684081975 3935692.768106903 1.0 0.9642766701864389 0.22550604991741155 24.056948129329395 -6.916972320190783 0.8468896241387939 1.0181469796170874 0.11429596935180442 0.9932973067010474 0.029225773206018844 0.09998662320680018 0.11509186821394737 0.02478514568567933 0.07222289900656124 1.2106752936219282e-07 6.916972320190783 -0.903851010265283 down K(ub)FMQTFVLAPEGSVPNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFMQTFVLAPEGSVPNK 17 1 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 9548200.0 3326200.0 4275800.0 1946200.0 True False 4360680.4109666245 3637867.3069378566 1744825.893268642 1.0 0.8342430456011007 0.40012698222061854 22.0561218302301 -6.954457828201511 0.5075537318809804 1.0081530351140102 0.20725099073589467 0.9995062594530533 0.00562025616950532 0.08174361187235081 0.02892525438318547 0.006501109137228508 0.035823135548935535 1.110560370123766e-07 6.954457828201511 -0.8009020443781155 down K(ub)FMQTFVLAPEGSVPNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFMQTFVLAPEGSVPNK 17 1 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 19912600.0 5708400.0 7058800.0 7145400.0 True False 5527189.966620186 9877415.651155721 5273805.382594855 1.0 1.7870591947820547 0.9541567079192913 22.39811476740024 -6.6589557234526975 1.9764908436657085 1.5070562788536823 0.9576303384815982 0.23119054222760682 0.33519607032853066 0.48694368751799094 3.655666224193707 0.1370650315852493 0.3715639088518293 2.1930285043453095e-07 6.6589557234526975 -0.5494259403720841 K(ub)FMQTFVLAPEGSVPNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFMQTFVLAPEGSVPNK 17 1 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 60233000.0 17029000.0 16513000.0 26691000.0 True False 25834237.986659337 13566126.133342117 21415512.15091913 1.0 0.5251219772902763 0.8289585379672505 24.62278099449721 -10.234190209150132 5.159619875511826 1.0000361293807363 0.6770402576286526 0.6010297479729257 0.12404075647718582 5.155759098860126e-05 7.652370297411365e-06 0.12011535947083707 0.04003398200720295 5.831896271649158e-11 10.234190209150132 -0.32299587175208366 K(ub)FMQTFVLAPEGSVPNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFMQTFVLAPEGSVPNK 17 1 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 13257100.0 3326200.0 5858300.0 4072600.0 True False 4555986.027175176 5599460.935192534 3110735.757829841 1.0 1.2290338253439153 0.6827799161971035 22.119331891752992 -6.792817225069608 1.4851041175778974 1.127540065647611 0.6765148685176432 0.8103059971861283 0.09754927310523821 0.23117952192268107 1.0071928534685866 0.051694296237643544 0.12078299698212132 1.611323625831219e-07 6.792817225069608 -0.4510251971299677 K(ub)FMQTFVLAPEGSVPNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFMQTFVLAPEGSVPNK 17 1 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 19046300.0 5708400.0 7410400.0 5927500.0 True False 4746787.524998126 7370478.70435077 7166912.844336588 1.0 1.552729854777665 1.5098448806889493 22.178520042834517 -10.068158537967978 4.573556778894874 0.9999721738720264 1.5312873677537309 0.9951370975711124 0.01750771744853049 2746627.2278340436 3023192.0537545714 652.3591145741761 0.005993357248449499 8.54754630173966e-11 10.068158537967978 0.5313151938817045 K(ub)FMQTFVLAPEGSVPNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFMQTFVLAPEGSVPNK 17 1 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 62424000.0 17029000.0 19070000.0 26325000.0 True False 22044376.191773843 18008737.736122724 21534120.1173101 1.0 0.8169311564753158 0.9768532314081017 24.393907316589658 -10.222289176317565 6.27959050707781 1.0000013476776863 0.8968921939569586 0.3566024887930507 0.06528791369874408 1.2318793233933673e-06 1.525595934345668e-07 0.06321557671236622 0.021071583538655177 5.993918364534608e-11 10.222289176317565 -0.10310915372072771 K(ub)FSCPICEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFSCPICEKR 10 2 Q9Y2Y9;A0A087X1K6;H0YK05 Q9Y2Y9 KLF13 Krueppel-like factor 13 2 5061400.0 1464600.0 1492900.0 2103900.0 True False 1920104.7832065776 1270165.139278622 1886208.6100338574 1.0 0.6615082418353464 0.9823467065604026 20.87275361260791 -10.588131540780372 9.012234361215308 1.0000345733798703 0.8219274745027121 0.29114869967935275 0.1309817547390546 9.10062689109675e-05 4.158987138477999e-06 0.12684709592051177 0.0422741795634486 2.5814781841866988e-11 10.588131540780372 -0.17810709887715825 K(ub)FSCPICEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFSCPICEKR 10 2 Q9Y2Y9;A0A087X1K6;H0YK05 Q9Y2Y9 KLF13 Krueppel-like factor 13 2 5244800.0 1464600.0 1022800.0 2757400.0 True False 2006102.1993267878 977609.3140526998 2106158.910435594 1.0 0.48731780184517426 1.0498761783633872 20.9359636741308 -6.666819185595449 1.9482085878224444 0.6718829493735695 1.0475988983314586 0.2652896357846991 0.2179338323308617 0.46841717699623225 3.424329743176092 0.09014624388378362 0.24189031335311958 2.1536782116681635e-07 6.666819185595449 0.37571594895788907 K(ub)FTFGLDWVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFTFGLDWVPK 11 1 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 1 12074400.0 2931800.0 2823500.0 6319100.0 True False 2838731.6137861847 3950938.274357987 4663938.1410634965 1.0 1.3917970459660278 1.6429655126301024 21.436815026078303 -8.957181032160305 0.09024695015911838 4.981431889941196e-19 2.5294843423636544 0.9999766403411684 0.0012787221201198216 0.4475265096583812 0.02856490469664683 0.44206178538001983 0.3339667244855104 1.1036184895206334e-09 8.957181032160305 2.5294843423636544 K(ub)FTFGLDWVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFTFGLDWVPK 11 1 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 1 4579900.0 1021400.0 1710800.0 1847700.0 True False 1399039.1822971317 1635211.1991409452 1411311.3145759949 1.0 1.1688101518758283 1.008771828862372 20.416004937340904 -10.895892547505944 2.9176842163444423 0.9558840531708006 1.0887909904077295 0.2909913475735785 0.06533537197677314 49450726.967468195 13533528.144303907 14609169.833072871 0.02391029756881584 1.2708885076546782e-11 10.895892547505944 0.13290693723692892 K(ub)FTFGLDWVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFTFGLDWVPK 11 1 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 1 12579900.0 2931800.0 7823700.0 1824400.0 True False 2437921.600761947 7781552.175217134 2205873.604927482 1.0 3.191879580042726 0.9048172854443142 21.21722030151258 -6.655841811645643 1.9878160441862305 2.415710757082996 0.9144438798906812 0.2180005200642483 0.93419256317685 0.4943898021713994 3.7509112147872368 0.38029005377460146 1.0350781076145739 2.2088091278909838e-07 6.655841811645643 -1.501266877192315 K(ub)FVADGIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFVADGIFK 9 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 1 35701800.0 5057100.0 5401700.0 25243000.0 True False 6629907.073026061 4595787.415661691 22631096.50795412 1.0 0.6931903215295074 3.413486231206662 22.66055721851211 -6.878878138519798 1.0860908737583048 0.8125465141426562 3.602131159850228 0.9727668173227186 0.20075422617743297 0.1286259566218379 0.2783604454195584 0.14253323750044575 0.34370554761501176 1.3216664370420408e-07 6.878878138519798 2.789584645707572 up K(ub)FVADGIFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFVADGIFK 9 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 1 31189000.0 7201100.0 8818900.0 15169000.0 True False 6972505.022182851 12340332.759955952 11195783.839754421 1.0 1.7698564175566014 1.6057046648421642 22.733245637728093 -10.080178794104729 4.464905846368279 0.9999531432768439 1.6877805411041582 0.9590283010451278 0.06701467268588215 23278228.315620698 1.519608604176626 12867.962819812612 0.02294090490566836 8.314214138838496e-11 10.080178794104729 0.6878273978273143 K(ub)FVADGIFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFVADGIFK 9 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 1 91750000.0 12882000.0 13243000.0 65625000.0 True False 19542935.80034913 10879683.18196873 52654189.98554076 1.0 0.5567066940768626 2.6942825030720363 24.220143873915813 -6.85262393154751 1.2224832420706175 0.7628203117299133 2.7840978334199677 0.9440204391677789 0.21793947659521573 0.15459640018611584 0.4432975919299738 0.13940628026207982 0.32315815796473113 1.4040289685803822e-07 6.85262393154751 2.0212775216900543 up K(ub)FVADGIFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFVADGIFK 9 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 1 48495300.0 5057100.0 9063200.0 34375000.0 True False 6926846.532988859 8662757.856005507 26256332.97534768 1.0 1.2506062917302168 3.7905174959922716 22.723767280035002 -6.925978082771683 0.7791005739645598 0.9550792927513433 4.2622744807901904 0.9956869868282324 0.0827849581964896 0.09478050088276166 0.08831059963832379 0.07368895757394858 0.2351046517089138 1.1858285910186293e-07 6.925978082771683 3.3071951880388473 up K(ub)FVADGIFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFVADGIFK 9 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 1 34427100.0 7201100.0 14282000.0 12944000.0 True False 5988033.712820399 14205060.031244963 15650530.55370606 1.0 2.3722411583675433 2.613634342137758 22.51365091316237 -10.412519740501015 0.36808520997954874 2.1291499506731623e-14 2.649980961892031 0.9991371988600399 0.020874080131477336 1.8683091246912118 0.1733566392525209 1.8601465472624956 0.0674884989567515 3.8679447280657994e-11 10.412519740501015 2.64998096189201 K(ub)FVADGIFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFVADGIFK 9 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;E9PK82;E9PQX2 P23396 RPS3 40S ribosomal protein S3 1 90371000.0 12882000.0 14245000.0 63244000.0 True False 16676002.942182774 13452253.22763863 51734240.93823969 1.0 0.8066833086009172 3.1023166113370833 23.991270196008262 -6.886444684409276 1.043213549373751 0.8659356392254117 3.2865189929051906 0.9785223174288191 0.15235712800344448 0.12207400876684751 0.2390924952926684 0.11176839143143384 0.2752953542597222 1.298838984928027e-07 6.886444684409276 2.420583353679779 up K(ub)FVHPSLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFVHPSLSR 9 1 E5RGS2;Q9H6H4;Q9H6H4-2 E5RGS2 REEP4 Receptor expression-enhancing protein;Receptor expression-enhancing protein 4 1 12484200.0 2609900.0 4187000.0 5687300.0 True False 2527050.153087031 5858890.934916554 4197625.514657212 1.0 2.3184703824573343 1.6610772483203056 21.269022866330225 -10.48842838540901 7.214098972144207 0.9997981597901991 1.9897738153888198 0.7513958117678963 0.26837962317412295 0.0008714147478324647 6.17943855097447e-05 0.25990750693315817 0.08661915091790001 3.2476679137092446e-11 10.48842838540901 0.9899756555986207 K(ub)FVHPSLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFVHPSLSR 9 1 E5RGS2;Q9H6H4;Q9H6H4-2 E5RGS2 REEP4 Receptor expression-enhancing protein;Receptor expression-enhancing protein 4 1 9095600.0 0.0 3006600.0 6089000.0 True False 0.0 2873758.4705033675 4650903.6068913955 0.0 K(ub)FVHPSLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFVHPSLSR 9 1 E5RGS2;Q9H6H4;Q9H6H4-2 E5RGS2 REEP4 Receptor expression-enhancing protein;Receptor expression-enhancing protein 4 1 12132100.0 2609900.0 7002700.0 2519500.0 True False 2170247.488174023 6964975.065172873 3046315.8011482065 1.0 3.209299908478632 1.4036720778381269 21.0494281417645 -6.596212529834784 2.204968481407 2.4894327450914218 1.4092908862067182 0.009801394524183493 0.9558507480660053 0.6515727703595349 5.981173063488981 0.36059076354196223 1.0640808339436425 2.533888323103898e-07 6.596212529834784 -1.0801418588847036 K(ub)FVIHPESNNLIIIETDHNAYTEATK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFVIHPESNNLIIIETDHNAYTEATK 26 1 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 1 42197600.0 8260600.0 13182000.0 20755000.0 True False 12531934.13075329 10829569.108563906 16652765.152760327 1.0 0.8641578383330478 1.3288264188920802 23.57910575608666 -6.8284459839270895 1.3347551156233108 0.9273313486080272 1.340945149190101 0.9027427288948977 0.060837035056243896 0.18273973863661216 0.6372505949600049 0.03579170573199354 0.08237716063158775 1.4844104945201206e-07 6.8284459839270895 0.41361380058207375 K(ub)FVIHPESNNLIIIETDHNAYTEATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFVIHPESNNLIIIETDHNAYTEATK 26 1 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 1 38170600.0 8260600.0 12883000.0 17027000.0 True False 10693509.54076967 12166049.724932842 13928260.71177357 1.0 1.1377041072015712 1.3024966834949003 23.350232078179108 -6.968738847633834 0.28671113712639484 0.9665073862010051 1.4787615969661072 0.9999708049225394 0.0006681335264554373 0.07671409423308767 0.010487651091468327 0.0029309788716070074 0.015001936913081722 1.07463542382244e-07 6.968738847633834 0.5122542107651021 K(ub)FYDANYDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFYDANYDGK 10 1 Q15555-4;Q15555-5;Q15555-3;Q15555;K7EL66;K7ERD8;Q15555-2;M0QX52 Q15555-4 MAPRE2 Microtubule-associated protein RP/EB family member 2 1 2986090.0 987730.0 718060.0 1280300.0 True False 956375.0518060678 1004785.1026334307 944951.0218232962 1.0 1.0506182702444433 0.9880548640816196 19.86721697054123 -6.691468351885786 1.8613490814351399 1.0316913459075232 0.9882682221325395 0.3772080936541359 0.021401730042764598 0.4135373134981522 2.77901775047207 0.009194633800759938 0.023897911047689388 2.0348464747486323e-07 6.691468351885786 -0.043423123774983696 K(ub)FYDANYDGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFYDANYDGK 10 1 Q15555-4;Q15555-5;Q15555-3;Q15555;K7EL66;K7ERD8;Q15555-2;M0QX52 Q15555-4 MAPRE2 Microtubule-associated protein RP/EB family member 2 1 13450100.0 1904800.0 2825700.0 8719600.0 True False 2889720.8595330697 2321431.7577051306 6996167.238063552 1.0 0.8033411774174738 2.421052959140841 21.462498707718854 -6.876506097922559 1.0991463330029916 0.882943601790347 2.5282661859465114 0.9707540725996694 0.1232551082004408 0.13076773616330625 0.29139799589935883 0.08663868746651787 0.20776868591140096 1.3289048978611476e-07 6.876506097922559 1.6453225841561645 up K(ub)FYDANYDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFYDANYDGK 10 1 Q15555-4;Q15555-5;Q15555-3;Q15555;K7EL66;K7ERD8;Q15555-2;M0QX52 Q15555-4 MAPRE2 Microtubule-associated protein RP/EB family member 2 1 17862200.0 1904800.0 2821400.0 13136000.0 True False 2465801.1492213733 2664386.6097900714 10745382.786742086 1.0 1.0805358780173355 4.357765341351698 21.233625029811304 -6.912185363405937 0.8807324764717177 0.9054091185940827 4.801686127875148 0.9917202165412619 0.14233436913176742 0.10299027511097018 0.1310639040566017 0.11780517756007546 0.33033165939967624 1.2240936262121712e-07 6.912185363405937 3.8962770092810652 up K(ub)GAAVDGGK(ub)LDVGNAEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGAAVDGGKLDVGNAEVK 18 2 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7 P51572-2 BCAP31 B-cell receptor-associated protein 31 2 7888300.0 2061600.0 2619400.0 3207300.0 True False 2702777.564562799 2228595.730341227 2875439.362594032 1.0 0.8245575808979768 1.063883095780826 21.366011353965217 -6.710240158862005 1.794597533976733 0.8921673210990686 1.0633189410418977 0.4661507582235105 0.07392766100173363 0.37458183908142123 2.351819102422411 0.03278230556418557 0.08325045421041886 1.9487666606420156e-07 6.710240158862005 0.17115161994282913 K(ub)GAAVDGGK(ub)LDVGNAEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGAAVDGGKLDVGNAEVK 18 2 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7 P51572-2 BCAP31 B-cell receptor-associated protein 31 2 7557900.0 1967300.0 1391900.0 4198700.0 True False 1904849.1383455778 1947692.9286626119 3098934.5116999703 1.0 1.022491959837956 1.6268661120279027 20.861245311935598 -6.914773073267727 0.8626164592569289 0.9839907204795693 1.7134972276478713 0.9926007626922108 0.024975679185428278 0.10134668687814373 0.12228055372832848 0.02094304938055381 0.05991388615000549 1.2168216459115883e-07 6.914773073267727 0.729506507168302 K(ub)GAAVDGGK(ub)LDVGNAEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGAAVDGGKLDVGNAEVK 18 2 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7 P51572-2 BCAP31 B-cell receptor-associated protein 31 2 13028000.0 1629000.0 5354100.0 6044900.0 True False 2471312.0958522544 4398619.023225762 4850122.86542621 1.0 1.779871927389591 1.962569953655975 21.2368457858614 -10.956719916519388 0.2783141144955884 2.779091809637237e-17 2.0302594649075014 0.9992132317649124 0.011708242467030531 2.838804162647056 0.1440456331344742 1.9045755371506248 0.07241211246168873 1.1047908875732133e-11 10.956719916519388 2.0302594649075014 K(ub)GADSLEDFLYHEGYACTSIHGDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGADSLEDFLYHEGYACTSIHGDR 24 1 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;A0A0J9YVQ7;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 1 47045300.0 6115000.0 6888300.0 34042000.0 True False 7915988.044670687 6504960.049697663 27846705.300416756 1.0 0.8217496051016681 3.5177801107423483 22.916338002843084 -6.891094203943041 1.0158684778407174 0.8589164856590766 3.754713160071123 0.9815901029333037 0.16703395741721128 0.11826057681907874 0.21668869749652067 0.12509800050583347 0.31313102603702214 1.2850078953138286e-07 6.891094203943041 2.8957966744120465 up K(ub)GAILSEEELAAMSPTAAAVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGAILSEEELAAMSPTAAAVAK 22 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 10365300.0 3709800.0 4613200.0 2042300.0 True False 4863583.725754304 3924928.542112758 1830982.3871249307 1.0 0.8070033875080524 0.37646774279411827 22.213588323087166 -6.957854154877064 0.46468978958813656 1.0119785610772523 0.15399969156351703 0.9996821447976738 0.00464682356840528 0.08047676132349085 0.024032469001970508 0.005895177287954818 0.03554983872578429 1.1019092914804786e-07 6.957854154877064 -0.8579788695137353 down K(ub)GAILSEEELAAMSPTAAAVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGAILSEEELAAMSPTAAAVAK 22 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 14791800.0 5915000.0 5196800.0 3680000.0 True False 5727231.562707304 7271909.34095399 2716097.602366424 1.0 1.2697075823343356 0.47424267250729163 22.449406504831142 -6.815209631242916 1.39233552495584 1.1461129441577622 0.4585783800865783 0.8730433875636849 0.11769176895152705 0.19977693263443094 0.7622263441535658 0.06644345679855204 0.15338117403481133 1.5303485936332002e-07 6.815209631242916 -0.6875345640711839 down K(ub)GAILSEEELAAMSPTAAAVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGAILSEEELAAMSPTAAAVAK 22 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 25398700.0 8301900.0 9550000.0 7546800.0 True False 12594589.250187734 7845727.885509441 6055171.672120054 1.0 0.6229443239200907 0.48077563720704874 23.58630073615426 -13.999999999999998 0.13530935478622572 2.795093772673342 0.2944796588532754 0.9996222785036364 0.004257889996926341 11.932132865753706 0.11488275050909344 5.672297620459844 0.16607693563286327 1.0000000000000041e-14 13.999999999999998 -2.5006141138200664 K(ub)GAILSEEELAAMSPTAAAVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGAILSEEELAAMSPTAAAVAK 22 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 12149900.0 3709800.0 6005300.0 2434800.0 True False 5081413.313575385 5739965.989128538 1859750.3862800437 1.0 1.1296002971838128 0.365990772943342 22.276798384610057 -6.86320915833349 1.1693340586357592 1.0710157144818244 0.3266668556923154 0.9574277631323722 0.06884085309799755 0.1435369791113668 0.371121672670717 0.04585165134987002 0.1074543021477895 1.3702217018005904e-07 6.86320915833349 -0.7443488587895091 down K(ub)GAKLTPEEEEILNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGAKLTPEEEEILNK 15 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 8650300.0 1993400.0 3842000.0 2814900.0 True False 2613366.7041130625 3268788.5759987067 2523641.1504274462 1.0 1.2507959831485205 0.96566668062909 21.317478145220687 -6.674457020500952 1.9220012721128645 1.1594667542180075 0.9668041469657512 0.29881100712144093 0.10642479654639507 0.4509271781175106 3.2156642947140592 0.04451541296804807 0.1182286335912904 2.116133095776677e-07 6.674457020500952 -0.19266260725225626 K(ub)GAKLTPEEEEILNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGAKLTPEEEEILNK 15 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 9748400.0 3969700.0 2229500.0 3549200.0 True False 3843684.046403923 3119750.976688909 2619558.046282315 1.0 0.8116564574571856 0.6815227304474006 21.87405831973858 -7.325694905648625 0.07380847550103475 1.5355409244486333 1.1758496317146755e-08 0.9999996411417528 7.810624027861954e-05 0.11335576123198761 0.004400529123120141 0.03790966621492254 0.05230725865602098 4.723947847556068e-08 7.325694905648625 -1.535540912690137 K(ub)GAKLTPEEEEILNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGAKLTPEEEEILNK 15 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 17655600.0 6004400.0 3223900.0 8427300.0 True False 9109113.7804391 2648569.8565543317 6761640.461183192 1.0 0.29076043184814176 0.7422939952405833 23.11887927134733 -10.249775308063384 5.395103627026835 1.0000433343290973 0.516527213545596 0.6045291269658724 0.1843378053421643 9.609177636150086e-05 1.3362367122063124e-05 0.1785002556081535 0.05949477084719812 5.6263234029235194e-11 10.249775308063384 -0.48351612078350126 K(ub)GAKLTPEEEEILNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGAKLTPEEEEILNK 15 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 8170700.0 1993400.0 1711700.0 4465600.0 True False 2730413.8496094625 1636071.4341650426 3410917.251918909 1.0 0.5992027305307779 1.2492308638145755 21.380688206743578 -6.739907519639921 1.6871139020426509 0.761499735741198 1.2495979880958845 0.6044860641742629 0.16839820606847974 0.31798742861607104 1.7771593824132044 0.07896549358867729 0.19378798134687358 1.8200883940651337e-07 6.739907519639921 0.4880982523546865 K(ub)GAKLTPEEEEILNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGAKLTPEEEEILNK 15 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 10351900.0 3969700.0 3720400.0 2661800.0 True False 3300981.437528039 3700357.466758423 3218370.0732273445 1.0 1.1209870569673543 0.9749736961978924 21.654463595172857 -6.686718995555443 1.878372171851468 1.0760841711087858 0.9755012659554507 0.3550099410460784 0.05120370132655489 0.42374226977210033 2.896141036929013 0.02182996404657617 0.05707671020722266 2.0572212629867946e-07 6.686718995555443 -0.10058290515333512 K(ub)GANEATK(ub)TLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGANEATKTLNR 12 2 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 2 34397400.0 6353400.0 14169000.0 13875000.0 True False 8329368.92641312 12055040.430329423 12439348.098398108 1.0 1.4472933708221147 1.4934322405809044 22.989775763447614 -11.822795122309067 0.36710964110903194 1.7488666100902388e-21 1.4990162695356994 0.9996290270651204 0.004286066052065133 4.852856694501352 0.18952687702617382 3.7695398289429503 0.013002170863847973 1.5038512380685586e-12 11.822795122309067 1.4990162695356994 K(ub)GANEATK(ub)TLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGANEATKTLNR 12 2 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 2 69844000.0 17488000.0 24255000.0 28101000.0 True False 16932853.012447216 33940147.988154024 20740505.08807034 1.0 2.0043963036355934 1.2248677215129753 24.013321737275895 -10.174162025855221 4.742016697193786 0.9999296543816826 1.6146320124837865 0.4532248821330648 0.31824121104084946 0.0002508700478482429 4.368948848698913e-05 0.30817288824686573 0.10271190920003336 6.696347366065428e-11 10.174162025855221 0.6147023581021039 K(ub)GANEATK(ub)TLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGANEATKTLNR 12 2 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 2 20461800.0 5905100.0 8677900.0 5878800.0 True False 8958468.420636667 7129260.9442578405 4716852.603230428 1.0 0.7958124770340121 0.5265244438842602 23.094820673166975 -6.967308059777318 0.3159439099168321 1.0386790453192913 0.27502368437309715 0.9999531210927329 0.0013276104359827988 0.07718627596216333 0.012142506036570959 0.004151135593608149 0.023773951423231847 1.0781816601706083e-07 6.967308059777318 -0.7636553609461942 K(ub)GANEATK(ub)TLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGANEATKTLNR 12 2 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 2 19006400.0 6353400.0 12653000.0 0.0 True False 8702423.674179161 12093948.62212438 0.0 1.0 1.3897218838021141 0.0 23.052985824970506 -6.860098619779221 1.3833791699301181 1.205768398430929 3.537716392134514e-20 0.908589014954855 0.17696178762267986 0.16534462908247202 0.6361448564195681 0.10315228888740098 0.21521204278591755 1.380070841933096e-07 6.860098619779221 -1.205768398430929 down K(ub)GANEATK(ub)TLNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGANEATKTLNR 12 2 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 2 55965000.0 17488000.0 33912000.0 4565000.0 True False 14542046.849759493 33729309.32499505 5519520.393824793 1.0 2.3194334108167785 0.3795559490936504 23.79372701271017 -6.723553041927157 1.7462457462426968 1.7996820271301934 0.38190955263352927 0.5292538400171023 0.5549989669473244 0.34851208347820317 2.078727572650395 0.2521565471115573 0.6304453738530506 1.8899353925703874e-07 6.723553041927157 -1.4177724744966642 K(ub)GANEATK(ub)TLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGANEATKTLNR 12 2 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 2 14671500.0 5905100.0 7112600.0 1653800.0 True False 7644268.356923102 6716777.557522116 1352825.3694209864 1.0 0.8786684668702145 0.1769725114628907 22.865946995259424 -6.936619492685579 0.6903061187659895 1.00852372306873 0.005197654466104658 0.9976865862847036 0.017448894665523167 0.0893435582568022 0.06189210320735544 0.01657790005915418 0.06134697769353248 1.157125614344842e-07 6.936619492685579 -1.0033260686026253 down K(ub)GASSAYLENSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGASSAYLENSK 12 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77;A0A0D9SF91;A0A0D9SES7 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 5094600.0 1505300.0 1949100.0 1640200.0 True False 1457515.075459561 2727385.794422227 1210582.4150547313 1.0 1.8712573477583208 0.8305796869188672 20.475079374999186 -6.684631538019862 1.8857479980042944 1.5489513255677934 0.834414335464047 0.34534435399446095 0.36889195738941033 0.42829159668055455 2.9485378942217495 0.15675406862774602 0.4109436645584789 2.0671331989940957e-07 6.684631538019862 -0.7145369901037464 K(ub)GASSAYLENSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGASSAYLENSK 12 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77;A0A0D9SF91;A0A0D9SES7 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 5034910.0 1505300.0 2883200.0 646410.0 True False 1251723.6460969222 2867667.629329608 781571.3423378508 1.0 2.290975039315956 0.6243960835723742 20.255484650433463 -6.699904575090306 1.8313188563607208 1.8017170653946417 0.6293784143614461 0.41710291299864977 0.5449452798804285 0.3957063718003977 2.5800186711197273 0.23740751703401777 0.6105966941224925 1.9957007701028057e-07 6.699904575090306 -1.1723386510331957 K(ub)GAVECCPNCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGAVECCPNCR 11 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 27886900.0 5516900.0 10580000.0 11790000.0 True False 7232709.325735605 9001505.24051699 10570083.89766585 1.0 1.2445550947951982 1.4614279962911154 22.78610474189738 -6.972542775752976 0.18777075897293374 0.8486644470825331 1.8632295942559431 0.999996020202911 0.0003759827662030836 0.07548596725617802 0.005974623323653581 0.00780414802807332 0.02378952206021164 1.0652639355300601e-07 6.972542775752976 1.01456514717341 K(ub)GAVECCPNCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGAVECCPNCR 11 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 96724000.0 17405000.0 27943000.0 51376000.0 True False 26404657.475941367 22956353.330344487 41221511.08109923 1.0 0.8694054581568117 1.5611454577154902 24.65428909094693 -6.857867870102826 1.1965047410993759 0.9295093723296834 1.5932966634480368 0.9509887281796028 0.06643364342133667 0.1490171783211944 0.406605950372053 0.043341703426392736 0.1009391269121658 1.3871778001121539e-07 6.857867870102826 0.6637872911183533 K(ub)GAVECCPNCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGAVECCPNCR 11 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 29182700.0 5516900.0 8490800.0 15175000.0 True False 7556647.018616657 8115648.380679173 11590977.538935306 1.0 1.0739747881150665 1.5338783868532722 22.84931480342027 -6.935087223292816 0.7037796393508683 0.9941485167810004 1.641815960770862 0.9974470714035443 0.011933122317127289 0.09008084720189462 0.06536074304579488 0.011221897505185202 0.04051273244947538 1.1612153730224195e-07 6.935087223292816 0.6476674439898616 K(ub)GAVECCPNCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGAVECCPNCR 11 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 64362000.0 17405000.0 15942000.0 31015000.0 True False 22531115.60384189 15054813.685855728 25370588.24077392 1.0 0.6681787955181704 1.1260245025971043 24.425415413039378 -6.71234903796828 1.787293921008887 0.7964897412639779 1.1250033709394613 0.4760590253723085 0.139777570871964 0.3703642378362251 2.3077698570968317 0.06220864000652171 0.15756331241879645 1.9393266344119195e-07 6.71234903796828 0.3285136296754835 K(ub)GDCDKTYGSEFVYSDHAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGDCDKTYGSEFVYSDHAK 19 2 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 23374000.0 10744000.0 7001100.0 5628900.0 True False 16299433.4916124 5751699.005156028 4516345.447765485 1.0 0.35287723393060383 0.27708603799571146 23.958318486763325 -13.999999999999998 0.3026169603193065 6.992524313912399 0.25893832840207903 0.9996556616372583 0.006019674595743558 16.760942134304468 0.17478423206940777 62.983785183638915 0.027085872187583456 1.0000000000000041e-14 13.999999999999998 -6.733585985510319 K(ub)GDCDKTYGSEFVYSDHAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGDCDKTYGSEFVYSDHAK 19 2 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 6641000.0 2405700.0 2741300.0 1494000.0 True False 3295152.3015980097 2620180.3017331506 1141147.9698958374 1.0 0.7951621236027463 0.346311146025763 21.651913717313878 -6.958220079011952 0.45983167624841986 1.0131052165771404 0.11027908901143042 0.9996983836789513 0.00474112369511351 0.08034316301403817 0.023527655973989967 0.006094161638947428 0.03708028754285904 1.1009812451895578e-07 6.958220079011952 -0.9028261275657099 down K(ub)GDEYDVCAICLDEYEDGDKLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGDEYDVCAICLDEYEDGDKLR 22 2 C9IY58;C9JCY0;O43567-2;O43567;C9J7B4 C9IY58 RNF13 E3 ubiquitin-protein ligase RNF13 1 25591000.0 9145000.0 12272400.0 4173600.0 True False 11989183.56030598 10441405.757440519 3741755.907998144 1.0 0.8709021515034707 0.3120943047687102 23.51523008162904 -6.943065411566748 0.6304019464350931 1.0060957602038456 0.14676330500086582 0.9985384590213412 0.011413296278177556 0.08639562843950876 0.048447553688242696 0.011387367715064932 0.047484318650265284 1.1400780609756324e-07 6.943065411566748 -0.8593324552029797 down K(ub)GDEYDVCAICLDEYEDGDKLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGDEYDVCAICLDEYEDGDKLR 22 2 C9IY58;C9JCY0;O43567-2;O43567;C9J7B4 C9IY58 RNF13 E3 ubiquitin-protein ligase RNF13 1 21632000.0 9145000.0 7781800.0 4705200.0 True False 12526153.634332554 7437974.345028648 3593928.666635809 1.0 0.5937955546579063 0.2869139858531927 23.57844014315193 -7.925576292596525 0.24681144015709916 1.17355804900636 3.474071825745859e-09 0.9996697434823695 0.005307517991148706 0.10986193610163321 0.04188582475750544 0.06071897108729331 0.09280654750097656 1.1869261751750498e-08 7.925576292596525 -1.173558045532288 down K(ub)GDLSLRPEDGVWALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGDLSLRPEDGVWALR 16 2 Q12899 Q12899 TRIM26 Tripartite motif-containing protein 26 1 54394900.0 2244300.0 16747900.0 35402700.0 True False 3404767.1803076845 13759106.393060038 28405340.82744535 1.0 4.041129881843094 8.342814449027436 21.69912471872177 -6.966214237248276 0.33656357147594496 0.5144507463643905 12.011709340050647 0.999936030149987 0.024093360083156632 0.07755130724176937 0.013420277164571748 0.061383981109224356 0.3732831083223052 1.0809006120355135e-07 6.966214237248276 11.497258593686256 K(ub)GDLSLRPEDGVWALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGDLSLRPEDGVWALR 16 2 Q12899 Q12899 TRIM26 Tripartite motif-containing protein 26 1 50556600.0 2244300.0 20837900.0 27474400.0 True False 2905290.5917668706 19678252.547013722 22474341.111150037 1.0 6.773247606548806 7.735660307040793 21.47025104081422 -9.485502096912509 0.5375412211203284 4.552630589186765e-21 7.69110880342855 0.9984642629626448 0.11656386271193067 0.8093977725361574 0.23473916317428112 1.8886408141880668 0.18190523968853423 3.2696246815123873e-10 9.485502096912509 7.69110880342855 K(ub)GDNLVNKPDER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGDNLVNKPDER 12 2 O14593;K7ENE6 O14593 RFXANK DNA-binding protein RFXANK 1 10244190.0 440690.0 1315100.0 8488400.0 True False 570481.8922985966 1241913.5289341896 6943598.298339034 1.0 2.1769552122509057 12.171461341852158 19.121821569004034 -6.929003445741494 0.754931971599398 0.8422598464556607 14.172133711064072 0.9963386496211233 0.3032686440523321 0.09315865768194788 0.08024075938257864 0.2746716471422937 0.9093371408854033 1.1775966302990106e-07 6.929003445741494 13.32987386460841 K(ub)GDPDPFDDRHPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGDPDPFDDRHPGR 14 2 Q9Y4B6;Q9Y4B6-2;Q9Y4B6-3 Q9Y4B6 VPRBP Protein VPRBP 1 13784810.0 926910.0 2278900.0 10579000.0 True False 1199903.267127668 2152077.2116859 8653730.549706513 1.0 1.793542255149908 7.212023491211786 20.194486673774332 -6.933164272990678 0.720343574216996 0.9264905863081848 8.419698585625271 0.9971244280158735 0.14802534221465885 0.09102784608355005 0.06987270416793007 0.13749225633182285 0.482033249274375 1.1663683518202875e-07 6.933164272990678 7.493207999317087 K(ub)GDVEGSQSQDEGEGSGESER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGDVEGSQSQDEGEGSGESER 21 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 60500000.0 24255000.0 25591000.0 10654000.0 True False 31798539.88575411 21772922.55293671 9551626.280384395 1.0 0.684714538188311 0.3003793983843757 24.92245718607514 -7.186198208202998 0.32859142762392807 1.0553882899999933 5.541855968371715e-15 0.9998870852347242 0.003039943244165882 0.08736396824464247 0.01783381337449896 0.00878345293987765 0.04005985531855787 6.513310644157256e-08 7.186198208202998 -1.0553882899999878 down K(ub)GDVEGSQSQDEGEGSGESER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGDVEGSQSQDEGEGSGESER 21 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 61043000.0 24255000.0 26709000.0 10079000.0 True False 33222728.96672891 25528908.065148156 7698547.783520837 1.0 0.7684169500559158 0.23172532850117736 24.98566724759803 -7.020994645399045 0.4954502487693904 1.0109568283940402 6.532565711564883e-13 0.9996101885121189 0.006353220598634299 0.07425735833701545 0.026548485446460195 0.0076920189266828495 0.04038617325565904 9.528079115242849e-08 7.020994645399045 -1.010956828393387 down K(ub)GEEALFTTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGEEALFTTR 10 1 Q99442;F8WF48;F8WCJ7 Q99442 SEC62 Translocation protein SEC62 1 7565800.0 3013400.0 3522100.0 1030300.0 True False 3950596.581807109 2996616.409038273 923694.4393354643 1.0 0.758522503370248 0.2338113801822158 21.91363910125316 -7.039576196273335 0.48223686165172525 1.0123045005258278 9.603702316243843e-14 0.9996488736747821 0.005993274322827503 0.07377069068216803 0.025439158722321265 0.0074534418505225915 0.03948910230792594 9.129012541745727e-08 7.039576196273335 -1.0123045005257316 down K(ub)GEEALFTTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGEEALFTTR 10 1 Q99442;F8WF48;F8WCJ7 Q99442 SEC62 Translocation protein SEC62 1 13318700.0 3344700.0 5350200.0 4623800.0 True False 3238524.32929622 7486562.760924423 3412688.0689733378 1.0 2.3117204009245054 1.0537787343765195 21.626905151640475 -6.636416658791319 2.0575789657079153 1.860132427439767 1.058991388406513 0.14089459553243544 0.5617565275235464 0.5425081166641004 4.385168410081056 0.22268437842016478 0.6220050814317084 2.3098476766793892e-07 6.636416658791319 -0.8011410390332541 K(ub)GEEALFTTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGEEALFTTR 10 1 Q99442;F8WF48;F8WCJ7 Q99442 SEC62 Translocation protein SEC62 1 27109900.0 14656600.0 3139600.0 9313700.0 True False 22235133.740987204 2579313.850193235 7472843.11266028 1.0 0.1160017241289918 0.3360826698732732 24.40633774652087 -10.376475363042806 5.178676478397638 1.0004567566845293 0.22604219740896886 0.9428229515919452 0.08984766986392898 0.00047408411324354637 5.708075486694897e-05 0.0870433555658613 0.028998210756522494 4.202663681617593e-11 10.376475363042806 -0.7744145592755605 K(ub)GEEALFTTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGEEALFTTR 10 1 Q99442;F8WF48;F8WCJ7 Q99442 SEC62 Translocation protein SEC62 1 15914400.0 3344700.0 10315800.0 2253900.0 True False 2781266.2453334094 10260226.737874024 2725180.069143856 1.0 3.6890487399720553 0.9798343016301807 21.40731042707475 -6.647909635366736 2.0163120732936735 2.7478182231134376 0.9912742393665952 0.1855494122445096 1.1483103045356697 0.5136314683376724 4.000244441453102 0.46229640129000665 1.2715453535743624 2.2495226203935623e-07 6.647909635366736 -1.7565439837468424 K(ub)GEEALFTTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGEEALFTTR 10 1 Q99442;F8WF48;F8WCJ7 Q99442 SEC62 Translocation protein SEC62 1 30740900.0 14656600.0 8998600.0 7085700.0 True False 18973257.62477846 8497819.999594864 5796175.305421628 1.0 0.44788407808772834 0.3054918359329086 24.177464068613318 -13.999999999999998 0.19026822082241468 3.9624206284113104 0.20361346967107916 0.9994892622044792 0.006769166120722244 12.355095802614322 0.13832743975025194 13.570827282888475 0.09771655421842976 1.0000000000000041e-14 13.999999999999998 -3.758807158740231 K(ub)GEGGTDPELEGELDSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGEGGTDPELEGELDSR 17 1 Q9UJX6;Q9UJX6-2 Q9UJX6 ANAPC2 Anaphase-promoting complex subunit 2 1 5264440.0 845240.0 1640200.0 2779000.0 True False 1108117.8253158024 1395488.5534495255 2491455.7380503276 1.0 1.2593322854018933 2.2483671692044913 20.079679859521057 -6.945970782824309 0.6014547217569377 0.988894617869468 2.5695605841753775 0.9988459541573217 0.018272559640168398 0.08514515525797765 0.04297730697813499 0.01872709401065793 0.08315560268640347 1.1324765480702346e-07 6.945970782824309 1.5806659663059095 up K(ub)GEGGTDPELEGELDSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGEGGTDPELEGELDSR 17 1 Q9UJX6;Q9UJX6-2 Q9UJX6 ANAPC2 Anaphase-promoting complex subunit 2 1 8592300.0 1947400.0 1555500.0 5089400.0 True False 1885580.8529528645 2176619.261825342 3756333.4612727338 1.0 1.1543494718970575 1.9921359804806176 20.84657758331647 -6.937992105825922 0.6779918691169741 0.9901895134820158 2.20530791615397 0.9978888281699909 0.020028302178477623 0.08869479024528654 0.05887263801729838 0.01921127170921239 0.0727675744512253 1.1534742243402266e-07 6.937992105825922 1.2151184026719541 K(ub)GEGGTDPELEGELDSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGEGGTDPELEGELDSR 17 1 Q9UJX6;Q9UJX6-2 Q9UJX6 ANAPC2 Anaphase-promoting complex subunit 2 1 22887100.0 0.0 9102100.0 13785000.0 True False 0.0 7477759.139968112 11060388.707819877 0.0 K(ub)GEGGTDPELEGELDSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGEGGTDPELEGELDSR 17 1 Q9UJX6;Q9UJX6-2 Q9UJX6 ANAPC2 Anaphase-promoting complex subunit 2 1 4738140.0 845240.0 1129900.0 2763000.0 True False 1157748.0697521307 1079977.2819203613 2110436.3057712177 1.0 0.9328258108446514 1.822880435657348 20.14288992104395 -6.888703005787778 1.0300027872224446 0.9506788944542927 1.8975221972877097 0.9800558734650683 0.05714940207830688 0.12020267365750988 0.2280341722739281 0.04234589859487562 0.10509009274790243 1.2921025816468956e-07 6.888703005787778 0.946843302833417 K(ub)GEIFELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGEIFELK 8 1 P63010;P63010-2;A0A087X253;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;A0A087WXS3;K7EKZ5;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 1 16179000.0 3524600.0 9632600.0 3021800.0 True False 4620784.732274948 8195453.627580711 2709133.123152385 1.0 1.7736064548382129 0.5862928658480482 22.139706449801697 -6.730880064014165 1.7199717731961208 1.4651068989724356 0.5868872217785556 0.5633015893964374 0.325185713910536 0.3346229599502098 1.9397271559555236 0.1497993171406922 0.37135406505356244 1.8583175824462885e-07 6.730880064014165 -0.87821967719388 K(ub)GEIFELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGEIFELK 8 1 P63010;P63010-2;A0A087X253;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;A0A087WXS3;K7EKZ5;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 1 17906400.0 4709600.0 7387800.0 5809000.0 True False 4560096.325904708 10337787.066868056 4287448.633735472 1.0 2.2670106787310185 0.9402101024444602 22.12063286902938 -6.656616178538262 1.9846897301901254 1.8178203798496158 0.9457474133204331 0.22135976392400858 0.5399038263846484 0.49254918483817284 3.725917303209231 0.22004546117719356 0.5983881865949839 2.204874229448407e-07 6.656616178538262 -0.8720729665291826 K(ub)GEIFELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGEIFELK 8 1 P63010;P63010-2;A0A087X253;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;A0A087WXS3;K7EKZ5;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 1 15470400.0 3524600.0 6360600.0 5585200.0 True False 4827739.868733566 6079567.660308563 4266090.790804701 1.0 1.2592989319251333 0.8836621083156663 22.202916511324588 -6.721000195548523 1.755679937414357 1.157590055338503 0.8842151963926128 0.5171650798041179 0.10910151048827674 0.3534216110716197 2.129553343099841 0.049330691657712714 0.12369473991275601 1.901077423930461e-07 6.721000195548523 -0.2733748589458902 K(ub)GEQELAEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGEQELAEVK 10 1 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 22496800.0 9774400.0 5434200.0 7288200.0 True False 12814333.055424256 4623438.542345689 6534086.9773510005 1.0 0.3608021207462378 0.5099045692889298 23.611255057185843 -10.187463462544939 8.080784340841815 1.0000001534066634 0.43535334501895917 0.9503019966990973 0.06087081972153011 1.6823549220007327e-07 1.6954548024407145e-08 0.0589379335707685 0.019645972587623343 6.494362667403019e-11 10.187463462544939 -0.5646468083877042 K(ub)GEQELAEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGEQELAEVK 10 1 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 18073000.0 5111800.0 5945000.0 7016200.0 True False 4949528.707057851 8318869.502765441 5178446.738511761 1.0 1.6807397219260554 1.0462504704998439 22.238859727978866 -10.21123006598437 4.5125400796489465 0.9998997365568447 1.3634950962175385 0.3044010898940299 0.25902915222805256 182292369.86865005 34.59288070773917 189910.2641684441 0.08867256857689709 6.14851071214689e-11 10.21123006598437 0.3635953596606938 K(ub)GEQELAEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGEQELAEVK 10 1 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 29094400.0 8361800.0 11512000.0 9220600.0 True False 12685461.929464335 9457593.656333467 7398144.36846746 1.0 0.7455458625725291 0.58319865761324 23.596672718986955 -9.11068752163022 0.08803086066857978 1.681671515841829 2.405280405346821e-06 0.9999763759799356 0.0008337316102716895 0.5729476914997346 0.029582211063552608 0.3213914263080629 0.2297579775138514 7.750192298040735e-10 9.11068752163022 -1.6816691105614237 K(ub)GEQELAEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGEQELAEVK 10 1 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 23714900.0 9774400.0 4481200.0 9459300.0 True False 13388259.823228015 4283205.766653266 7225208.160398722 1.0 0.31992251593609655 0.5396674590870516 23.674465118708735 -10.079364611285014 5.048615430638794 1.000012826170279 0.4297949875095686 0.8997760713353516 0.08971049738685313 49996360.02929137 99815788.96386279 4740.5132187875115 0.03071029972681149 8.329815625480244e-11 10.079364611285014 -0.5702178386607104 K(ub)GEQELAEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGEQELAEVK 10 1 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 16776700.0 5111800.0 7272500.0 4392400.0 True False 4250688.191136814 7233321.599021773 5310830.531837032 1.0 1.7016824744059331 1.2494048711713883 22.019265003413143 -10.265230661921159 4.560751831593129 0.9997881200785675 1.4755436727913191 0.5958028821795613 0.18464155834465673 0.0003979683410096754 6.411555406545597e-05 0.17885716822385397 0.05959280670594434 5.429618776903398e-11 10.265230661921159 0.4757555527127516 K(ub)GEQELAEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGEQELAEVK 10 1 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 24525800.0 8361800.0 9824600.0 6339400.0 True False 10824514.935719926 9277852.373482512 5185694.247736972 1.0 0.8571148387320742 0.47906943438404315 23.367799041079405 -6.954235768090967 0.5102274461628495 1.0069446167055602 0.31264778534659193 0.9994931344401354 0.004947903667058221 0.08182814262599607 0.029258379822315484 0.005696781026572771 0.03120146866533989 1.1111283584985662e-07 6.954235768090967 -0.6942968313589684 down K(ub)GEQMNSAVLPEMENQVAVSSLSAVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGEQMNSAVLPEMENQVAVSSLSAVIK 27 1 A0A2R8YFH0;E9PHA6;A0A2R8Y6P0;A0A2R8YG02;P43246;P43246-2;A0A2R8Y7S8 A0A2R8YFH0 MSH2 DNA mismatch repair protein Msh2 1 6653700.0 2227600.0 3126200.0 1299900.0 True False 2920405.1721090833 2659783.1458321596 1165398.8175212757 1.0 0.910758264378533 0.39905381234468845 21.477737109402607 -6.936802570037325 0.6886678873197196 1.0061835103876937 0.2731436989282442 0.9977143776256828 0.012658306535985703 0.08925611260335302 0.06148235510460299 0.012041604027541924 0.04469696597591021 1.1566379294748433e-07 6.936802570037325 -0.7330398114594495 down K(ub)GEQMNSAVLPEMENQVAVSSLSAVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGEQMNSAVLPEMENQVAVSSLSAVIK 27 1 A0A2R8YFH0;E9PHA6;A0A2R8Y6P0;A0A2R8YG02;P43246;P43246-2;A0A2R8Y7S8 A0A2R8YFH0 MSH2 DNA mismatch repair protein Msh2 1 33659300.0 9498500.0 9858800.0 14302000.0 True False 9196975.31671604 13795470.252962824 10555877.149196893 1.0 1.5000007913350328 1.1477552984197936 23.132728037770214 -10.06181329300441 8.660680073953326 0.9999999975734422 1.3238780448774132 0.5299041273624984 0.1438036203062472 6.598562127880101e-09 7.186953562877585e-10 0.13923725871740403 0.04641241888086916 8.673346703781063e-11 10.06181329300441 0.3238780473039711 K(ub)GEQMNSAVLPEMENQVAVSSLSAVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGEQMNSAVLPEMENQVAVSSLSAVIK 27 1 A0A2R8YFH0;E9PHA6;A0A2R8Y6P0;A0A2R8YG02;P43246;P43246-2;A0A2R8Y7S8 A0A2R8YFH0 MSH2 DNA mismatch repair protein Msh2 1 40607200.0 9498500.0 26625000.0 4483700.0 True False 7898423.604897114 26481565.8403513 5421220.939713523 1.0 3.3527659650885804 0.6863674589891966 22.91313331320449 -6.67374246188401 1.9239502816142113 2.496879824181911 0.6969099014684665 0.2958129035333721 0.9985459609664189 0.4525714220103577 3.2331099823325617 0.417289879468169 1.1095449672648887 2.119617703198539e-07 6.67374246188401 -1.7999699227134445 K(ub)GESDGAYIHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGESDGAYIHR 11 1 I3L0U5;Q6PK04 I3L0U5 CCDC137 Coiled-coil domain-containing protein 137 1 1888820.0 510930.0 784240.0 593650.0 True False 494710.8068189425 1097391.1217575723 438155.2558817466 1.0 2.218247724997046 0.8856795724741577 18.916225889546457 -6.666276438658047 1.9516087057721327 1.7801105046862231 0.8912555805652751 0.2623306838491155 0.5179385848556477 0.4696509273987767 3.445258863411612 0.21398287000337385 0.5742826187209807 2.156371391083242e-07 6.666276438658047 -0.888854924120948 K(ub)GESGQSWPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGESGQSWPR 10 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 11811500.0 2860900.0 5451200.0 3499400.0 True False 3750667.604995011 4637902.208611176 3137315.6566150817 1.0 1.236553781101417 0.8364685936010198 21.83871598218386 -6.746515206365228 1.6628144791638058 1.139678414987429 0.8358840698294974 0.6337917818225859 0.09938911846901102 0.30617266437155294 1.6644779880493954 0.047240174451556684 0.11510586164809176 1.792605785057535e-07 6.746515206365228 -0.3037943451579317 K(ub)GESGQSWPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGESGQSWPR 10 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 18720700.0 4631000.0 7384300.0 6705400.0 True False 4483991.4398812335 10332889.498615783 4949054.58231191 1.0 2.304395455957754 1.1037163314573577 22.096352093307683 -6.626413942734238 2.09268734763424 1.8615341480849328 1.1083929987379624 0.10505187477429623 0.5600117726370332 0.5683545256799064 4.738042935710915 0.21918700290677554 0.6208110675627656 2.363665722989045e-07 6.626413942734238 -0.7531411493469704 K(ub)GESGQSWPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGESGQSWPR 10 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 27927200.0 2534400.0 3537800.0 21855000.0 True False 3844870.089458538 2906451.949042439 17535349.670613203 1.0 0.7559298185421256 4.560713174338396 21.874503422528132 -6.891591874091796 1.0128885113679493 0.8032985114470373 4.898388519800869 0.9818987960579291 0.2339557118807962 0.11786222364545088 0.21436495890408452 0.17561173184602327 0.4404007145510661 1.283536212341186e-07 6.891591874091796 4.095090008353831 up K(ub)GESGQSWPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGESGQSWPR 10 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 18060100.0 4631000.0 10789000.0 2640100.0 True False 3850881.688085326 10730877.515551174 3192132.703556809 1.0 2.7866027535337263 0.8289355431077786 21.87675736874196 -6.666545403717649 1.9493894479801661 2.1437218706646046 0.8369116851445224 0.2639652795166977 0.7595136232779557 0.46907717274380856 3.433106819704822 0.31402031918157847 0.8428516832124923 2.1550363315253418e-07 6.666545403717649 -1.3068101855200822 K(ub)GESGQSWPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGESGQSWPR 10 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 14919900.0 2534400.0 3007900.0 9377600.0 True False 3280830.760492786 2840507.720843397 7670973.02230152 1.0 0.8657891638448149 2.3381190869928714 21.64562974462058 -6.8846230959771315 1.0536336768555532 0.9103960840553192 2.452192443040402 0.9772290012695405 0.10030233170563209 0.12361571696426316 0.2481838256988156 0.07299720021701736 0.1788002868422385 1.304298227307199e-07 6.8846230959771315 1.5417963589850827 up K(ub)GESQTDIEITR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGESQTDIEITR 12 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 31451500.0 8547500.0 13677000.0 9227000.0 True False 11205855.274107741 11636444.91252845 8272278.551633829 1.0 1.0384254149181837 0.7382103685336507 23.417749429313716 -6.874750975032084 1.1085997234618472 1.022503158972291 0.7189604130260885 0.9692017634537703 0.023409425359402446 0.1323839971937568 0.30121654472617804 0.01633530115470494 0.03902867555089527 1.334286294190061e-07 6.874750975032084 -0.30354274594620256 K(ub)GESQTDIEITR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGESQTDIEITR 12 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 47800000.0 13614000.0 15046000.0 19140000.0 True False 13181831.021926844 21053946.263853475 14126659.812307965 1.0 1.5971943676741147 1.0716765970379591 23.652047445997486 -10.241664286199288 4.571324195398088 0.9998857964347216 1.3344354823580964 0.35064665575850384 0.2145417314783181 151434247.5872124 36.368092903603284 182052.318544697 0.07344334115940825 5.732389789921036e-11 10.241664286199288 0.33454968592337475 K(ub)GESQTDIEITR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGESQTDIEITR 12 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 137013000.0 33356000.0 35810000.0 67847000.0 True False 50603490.650244154 29419425.715192955 54437010.71160348 1.0 0.5813714693820438 1.0757560399905106 25.592733570279382 -6.68229149638322 1.8936216621630204 0.735675809920235 1.0739142765960379 0.33467109214452684 0.17733652753213006 0.43346821755689874 3.007054855002878 0.07508890805960611 0.197471430700866 2.0783012729644437e-07 6.68229149638322 0.33823846667580293 K(ub)GESQTDIEITR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGESQTDIEITR 12 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 27924400.0 8547500.0 10108000.0 9268900.0 True False 11707741.737502182 9661395.13731392 7079776.718987638 1.0 0.8252142346432689 0.6047089932219577 23.480959490836607 -6.967974228989915 0.30269263079134434 1.0370396428932838 0.3859477047843637 0.9999619860233295 0.0009971759850844158 0.07696569675629944 0.011370724581644655 0.0036102764726127826 0.0197204422931044 1.0765290929102341e-07 6.967974228989915 -0.6510919381089201 K(ub)GESQTDIEITR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGESQTDIEITR 12 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 43680000.0 13614000.0 21915000.0 8151000.0 True False 11320644.202460315 21796939.545213092 9855336.414034162 1.0 1.9254151226196088 0.8705632151121137 23.432452721431762 -6.674980609552888 1.919860927866561 1.5881389374655048 0.8747322190102212 0.30127563591530615 0.3926503208495537 0.4497539039657363 3.2005545381437437 0.1643816665232173 0.4363312862355608 2.1135834053283684e-07 6.674980609552888 -0.7134067184552836 K(ub)GESQTDIEITR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGESQTDIEITR 12 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 167858000.0 33356000.0 41636000.0 92866000.0 True False 43179999.54505886 39318919.99901445 75965340.88562663 1.0 0.9105817603815552 1.7592714610002684 25.36385989237183 -6.88086116637291 1.0749491706966425 0.9439186062499013 1.820428358008883 0.9743749615311312 0.06095043641136757 0.1268716032637963 0.2676803856074892 0.04364240350759747 0.105776374499223 1.315645345532019e-07 6.88086116637291 0.8765097517589816 K(ub)GFCEGDEISIHADFENTCSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGFCEGDEISIHADFENTCSR 21 1 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 19864900.0 2667600.0 9195700.0 8001600.0 True False 4046944.2276829146 7554655.488667962 6420080.252774139 1.0 1.866755523090911 1.5864019594977141 21.948401536196666 -10.296384169457028 9.592951419061265 0.9999998708066755 1.7265787412943125 0.8995534497578774 0.11445386306237453 3.1659114974682206e-07 2.323902405029234e-08 0.11081949620258118 0.03693982546247339 5.053774160166759e-11 10.296384169457028 0.726578870487637 K(ub)GFCEGDEISIHADFENTCSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGFCEGDEISIHADFENTCSR 21 1 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 22911800.0 2667600.0 8672200.0 11572000.0 True False 3453260.786257315 8189584.446523517 9466014.738746924 1.0 2.3715511087708747 2.7411815454014126 21.719527858289116 -10.130791500938024 0.307195863558236 4.337273573294562e-12 2.858728757380727 0.9989309141847417 0.02449113279142971 1.560965287379119 0.14067873753354668 1.457220220017171 0.12794125421901337 7.399604350586763e-11 10.130791500938024 2.8587287573763898 K(ub)GFDQEEVFEKPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGFDQEEVFEKPTR 14 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 13973900.0 2246800.0 2439600.0 9287500.0 True False 2175476.5638361396 3413745.002345932 6854825.130972324 1.0 1.5691941062910302 3.150953333592722 21.05290004429524 -6.953157513774971 0.5230312373543151 0.9737376870448983 3.8173648937076017 0.999426349736472 0.021794886695744004 0.08224206099213122 0.030902629541362903 0.02457336596374592 0.1306950104034952 1.1138904646463672e-07 6.953157513774971 2.8436272066627035 K(ub)GFDQEEVFEKPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGFDQEEVFEKPTR 14 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 8685900.0 2246800.0 4671200.0 1767900.0 True False 1868313.7501166307 4646035.318439391 2137559.716153965 1.0 2.48675326515654 1.1441117510485197 20.833305319729515 -6.621848039657102 2.110442763411114 1.98526741091709 1.149347581203663 0.08880781397512316 0.6390660526829244 0.5805345858226341 4.916133346651871 0.2486228038279205 0.7082752486571662 2.388646928138285e-07 6.621848039657102 -0.8359198297134269 K(ub)GFDQEEVFEKPTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGFDQEEVFEKPTR 14 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 60212600.0 7490100.0 7183500.0 45539000.0 True False 9696082.101944037 6783731.910195995 37251369.26959865 1.0 0.6996363932227715 3.841899117389884 23.208970484261897 -6.8834616422735655 1.0603420751458275 0.8037617586826543 4.079882057911292 0.9763705893332657 0.21763490964176688 0.12460628842048431 0.25415111435787924 0.15758774673966028 0.3846579711316031 1.307791040447024e-07 6.8834616422735655 3.276120299228638 up K(ub)GFGDPFSGKDPFVPSSAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGFGDPFSGKDPFVPSSAAK 20 2 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 18685100.0 8078700.0 3180400.0 7426000.0 True False 10591253.93424209 2705896.7171021 6657628.755221937 1.0 0.2554840752475768 0.6285968400490773 23.336370069180973 -10.684408222698533 6.744482203279366 1.0041504920264621 0.4420404576523948 0.7488509911227317 0.15232264838045798 0.009537399202810234 0.00044627905881454476 0.14796723166461592 0.04916192336897684 2.0681963974409594e-11 10.684408222698533 -0.5621100343740673 K(ub)GFGDPFSGKDPFVPSSAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGFGDPFSGKDPFVPSSAAK 20 2 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 33851400.0 7296700.0 11379300.0 15175400.0 True False 7065070.252511648 15923113.832265563 11200507.487758527 1.0 2.253779971487879 1.58533561414718 22.75227247559411 -10.036478382713293 4.923912138875208 0.9999853480533516 1.919557792827251 0.716173952193552 0.2728912661920419 188761220.7612854 6.9814316342534335 35458.632730980156 0.0934179388940113 9.194362391941926e-11 10.036478382713293 0.9195724447738993 K(ub)GFGDPFSGKDPFVPSSAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGFGDPFSGKDPFVPSSAAK 20 2 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 19638100.0 8078700.0 2820100.0 8739300.0 True False 11065613.708658546 2695498.6571763945 6675257.331533251 1.0 0.2435923328018616 0.6032433001262317 23.399580130703864 -10.646023828960564 6.63556237647265 1.0025824400939864 0.4234178164699068 0.7741071956810821 0.14682689257384876 0.005625734195881808 0.00030010605621204545 0.14257881651634474 0.04738817580949181 2.259311802427043e-11 10.646023828960564 -0.5791646236240797 K(ub)GFGDPFSGKDPFVPSSAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGFGDPFSGKDPFVPSSAAK 20 2 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 29883500.0 7296700.0 15518800.0 7068000.0 True False 6067529.348618492 15435197.144159382 8545886.121260393 1.0 2.5439015219059145 1.4084622636734663 22.532677751028388 -10.443452956153765 4.98303141989163 0.9983547218082109 1.9761818927897672 0.4963576164607886 0.46354113609922 0.008483941771780617 0.0009475572108855664 0.44941614179467465 0.14960725836615726 3.602027663309469e-11 10.443452956153765 0.9778271709815562 K(ub)GFSEGLWEIENNPTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGFSEGLWEIENNPTVK 17 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 11809400.0 4213300.0 3877200.0 3718900.0 True False 4079551.0977438237 5425386.179330895 2744808.5253914366 1.0 1.3298978366348637 0.6728212147923432 21.959978980175563 -6.770196112295371 1.5736159524980537 1.1891740642989779 0.6690910049889146 0.7313306102424572 0.13904351051199249 0.26611852072715647 1.3005332224255792 0.06964451584584697 0.1657589263319202 1.6974769577652396e-07 6.770196112295371 -0.5200830593100633 K(ub)GGEMEILNNTDNQGIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGGEMEILNNTDNQGIK 17 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2;E9PDT6 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 1 32910400.0 9307000.0 15617000.0 7986400.0 True False 12201567.129116202 13287004.474589227 7160043.938958316 1.0 1.0889588471699574 0.5868134693839889 23.540563118901957 -6.861123603567483 1.1799359936989813 1.0484220356839167 0.5619574645617436 0.9549984953448328 0.04641126823091697 0.14565482917911382 0.38468185899159 0.03066243739293473 0.07167348113632638 1.3768175602033826e-07 6.861123603567483 -0.4864645711221731 K(ub)GGEMEILNNTDNQGIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGGEMEILNNTDNQGIK 17 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2;E9PDT6 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 1 21841600.0 7935300.0 8259300.0 5647000.0 True False 7683398.245063614 11557281.56168051 4167881.2936313045 1.0 1.5041887968134109 0.5424528523312013 22.87331310253143 -6.764249560829574 1.5963700322102445 1.2913116193935383 0.5381701082336341 0.7080917081641671 0.21221379635871174 0.27584649022385505 1.3863356816665902 0.10483911280754947 0.2509097604123392 1.7208794131889967e-07 6.764249560829574 -0.7531415111599042 K(ub)GGEMEILNNTDNQGIK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 KGGEMEILNNTDNQGIK 17 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2;E9PDT6 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 1 28812100.0 11686200.0 9640300.0 7485600.0 True False 16006903.94768036 9214359.66979101 5717655.450771263 1.0 0.5756490886625397 0.35719933532804365 23.932190953248078 -10.459107407693233 0.1370937031919725 1.8424575416487603 1.0874486950152024e-11 0.9997652476373993 0.004088912363042753 2.261147427142116 0.07148121123851532 0.8623341660601905 0.22226716913231453 3.474502210422782e-11 10.459107407693233 -1.8424575416378859 K(ub)GGEMEILNNTDNQGIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGGEMEILNNTDNQGIK 17 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2;E9PDT6 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 1 20816400.0 7935300.0 8816600.0 4064500.0 True False 6598553.543395276 8769103.22584192 4914368.157875327 1.0 1.3289432552410254 0.7447644586887214 22.653718377965706 -6.75394338152992 1.6354713308984459 1.1925017870366355 0.7432603126833949 0.6656913716267687 0.13825893756719101 0.2932081281816433 1.5442048322766793 0.06675188808210539 0.1613763021985809 1.762205768168014e-07 6.75394338152992 -0.4492414743532406 K(ub)GGSYSQAASSDSAQGSDVSLTACK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGGSYSQAASSDSAQGSDVSLTACK 25 1 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913 Q53Z42 HLA-A 1 18518800.0 5978100.0 7240500.0 5300200.0 True False 7837346.99200276 6160245.623247945 4751786.14710844 1.0 0.7860115967219351 0.6063003401479059 22.90193394187571 -6.973140183952558 0.16692267246557563 1.1655145481896223 0.22199866789875575 0.999997659853542 0.0002461157743732291 0.07529631790784459 0.005189729745372356 0.007792098166419013 0.021039755571191893 1.063799583740803e-07 6.973140183952558 -0.9435158802908665 K(ub)GGSYSQAASSDSAQGSDVSLTACK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGGSYSQAASSDSAQGSDVSLTACK 25 1 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913 Q53Z42 HLA-A 1 7725100.0 2523500.0 1951700.0 3249900.0 True False 2443392.873794062 2731023.987981046 2398653.6950898455 1.0 1.1177179148191403 0.9816897318544003 21.220454422902417 -6.677820216618108 1.9096602973085386 1.074626677953327 0.9822162018470845 0.3141735224023675 0.049915577780419065 0.4433778829820849 3.1242242957996313 0.020988555801006406 0.05551040944805112 2.0998089543652483e-07 6.677820216618108 -0.09241047610624242 K(ub)GGSYSQAASSDSAQGSDVSLTACK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGGSYSQAASSDSAQGSDVSLTACK 25 1 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913 Q53Z42 HLA-A 1 17128500.0 4589400.0 4298000.0 8241100.0 True False 6962455.330082463 3530988.319572724 6612242.972797561 1.0 0.5071469980304927 0.9496998773160167 22.73116473572295 -10.363110472064712 8.53369177174829 1.0000009974091837 0.7284234376732548 0.3342667692578595 0.18067145640817553 3.4285004458438995e-06 2.559797123417125e-07 0.17493502663971625 0.058311461816991934 4.3340061967300774e-11 10.363110472064712 -0.2715775597359289 K(ub)GGSYSQAASSDSAQGSDVSLTACK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGGSYSQAASSDSAQGSDVSLTACK 25 1 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913 Q53Z42 HLA-A 1 15851500.0 5978100.0 4903400.0 4970000.0 True False 8188365.122078022 4686751.5746245645 3796188.360362987 1.0 0.5723671947636811 0.463607607106753 22.965144003398603 -13.999999999999998 0.1922474499983751 3.3104489779613684 0.3873225167237247 0.9994883285612063 0.005237024303069544 12.388200948473768 0.13904603495095688 10.730277701853945 0.07348026688183663 1.0000000000000041e-14 13.999999999999998 -2.9231264612376435 K(ub)GGSYSQAASSDSAQGSDVSLTACK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGGSYSQAASSDSAQGSDVSLTACK 25 1 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913 Q53Z42 HLA-A 1 10065500.0 2523500.0 2653900.0 4888100.0 True False 2098402.060005037 2639602.913942092 5910179.10997919 1.0 1.2579109429275703 2.816514157427487 21.000859698336694 -6.935684110802803 0.6985686754275499 0.9805354069035557 3.188317724098752 0.9975420704370581 0.03978399368359207 0.08979200469252079 0.06399817325604837 0.03756058642237626 0.13688918539116063 1.1596205130911786e-07 6.935684110802803 2.2077823171951962 up K(ub)GGSYSQAASSDSAQGSDVSLTACK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGGSYSQAASSDSAQGSDVSLTACK 25 1 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913 Q53Z42 HLA-A 1 15316700.0 4589400.0 4004200.0 6723100.0 True False 5941068.77059879 3781362.7500253115 5499564.784831444 1.0 0.636478535434323 0.9256861007985189 22.5022910578154 -9.88171095304375 6.2389296285182585 1.0000000230862918 0.7810823181163754 0.4330996559503192 0.11806849414931156 3.792541990790844e-08 6.826055076913832e-09 0.11431933981236929 0.03810644262931541 1.31307353119499e-10 9.88171095304375 -0.21891770496991636 K(ub)GGSYSQAASSDSAQGSDVSLTACK(ub)V ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGGSYSQAASSDSAQGSDVSLTACKV 26 2 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913 Q53Z42 HLA-A 2 22024300.0 6827200.0 7277000.0 7920100.0 True False 8950525.314698849 6191299.965523839 7100604.0269637965 1.0 0.6917247589207174 0.7933170151815503 23.09354092730671 -10.723219884959068 9.861824620851667 1.0004799379047409 0.7425208870511338 0.8954465986844461 0.041474864942851714 0.0004384162423630013 1.2304491843070203e-05 0.04022794517813858 0.013385955100822203 1.8913857603293442e-11 10.723219884959068 -0.25795905085360704 K(ub)GGSYSQAASSDSAQGSDVSLTACK(ub)V ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGGSYSQAASSDSAQGSDVSLTACKV 26 2 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913 Q53Z42 HLA-A 2 22121000.0 9300000.0 0.0 12821000.0 True False 14108779.921071803 0.0 10286923.730356079 1.0 0.0 0.7291150466520716 23.75008989821864 -10.660680682621043 9.057838763371231 1.0005365084602735 0.3645575249538953 0.5031654937232622 0.29765997134718797 0.0032272732935707264 0.00012089772844139561 0.28841521234971856 0.09606934265501964 2.1843353660147022e-11 10.660680682621043 -0.6359789835063783 K(ub)GGSYSQAASSDSAQGSDVSLTACK(ub)V ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGGSYSQAASSDSAQGSDVSLTACKV 26 2 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913 Q53Z42 HLA-A 2 29006200.0 6827200.0 11991000.0 10188000.0 True False 9351400.338142725 11461197.971065622 7781804.2284463085 1.0 1.2256130158728638 0.8321538964282912 23.1567509888296 -6.751167447747385 1.645491782918861 1.132468219340915 0.8312972546361773 0.6541050324138684 0.09480926412126442 0.29795591772982444 1.5876426711685194 0.04550894023449342 0.11034971246099116 1.7735055514839987e-07 6.751167447747385 -0.3011709647047377 K(ub)GGSYSQAASSDSAQGSDVSLTACK(ub)V ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGGSYSQAASSDSAQGSDVSLTACKV 26 2 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913 Q53Z42 HLA-A 2 25511900.0 9300000.0 7691500.0 8520400.0 True False 12039033.330406757 7263461.263628119 6969774.626686774 1.0 0.6033259535284227 0.5789314171166341 23.52121622031109 -13.999999999999998 0.3966913162866638 7.54612954682237 0.5773869215514217 0.9998330364610053 0.0024938423893583824 26.287093648179056 0.20718899228556545 147.93023430193264 0.006299490286465559 1.0000000000000041e-14 13.999999999999998 -6.968742625270949 K(ub)GGSYSQAASSDSAQGSDVSLTACKV ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGGSYSQAASSDSAQGSDVSLTACKV 26 2 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913 Q53Z42 HLA-A 1 33075000.0 11178000.0 11139000.0 10758000.0 True False 14654466.247905968 9477104.619481921 9644865.358022831 1.0 0.6467041828177222 0.65815193776853 23.804837086655752 -9.998417196874648 5.421163137691276 1.0000012921142807 0.6524280602925336 0.9991870572541613 0.00467352639039725 7.298438465451781e-08 1.3483122435780286e-08 0.004525139257405745 0.0015083741562045949 1.0036511882889635e-10 9.998417196874648 -0.34757323182174704 K(ub)GGSYSQAASSDSAQGSDVSLTACKV ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGGSYSQAASSDSAQGSDVSLTACKV 26 2 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913 Q53Z42 HLA-A 1 19441900.0 7231200.0 5837600.0 6373100.0 True False 7001649.514158757 8168584.122681835 4703793.9210982155 1.0 1.1666656701629092 0.6718122510397284 22.739263415032248 -6.815892201865928 1.3898444745606124 1.0902203518361773 0.6619569673145048 0.87460105456867 0.07279904857579263 0.19887928193428567 0.7559950037915123 0.041174918940654524 0.09500780562053157 1.5279452691557357e-07 6.815892201865928 -0.42826338452167245 K(ub)GGSYSQAASSDSAQGSDVSLTACKV ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGGSYSQAASSDSAQGSDVSLTACKV 26 2 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913 Q53Z42 HLA-A 1 74808000.0 21206000.0 13902000.0 39700000.0 True False 32171052.366263293 11421079.483178241 31853277.59887186 1.0 0.35501106252760156 0.9901223384372507 24.939259793822234 -10.862561467978775 11.193119967788002 1.0094788763995308 0.6725667005107377 0.26166170766066255 0.2592830926444371 0.05955494062415366 0.0007312641409503543 0.24377727979245356 0.08368325831375496 1.3722667231461778e-11 10.862561467978775 -0.3369121758887931 K(ub)GGSYSQAASSDSAQGSDVSLTACKV ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGGSYSQAASSDSAQGSDVSLTACKV 26 2 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913 Q53Z42 HLA-A 1 47569000.0 11178000.0 18482000.0 17909000.0 True False 15310808.674091758 17665404.128199052 13679263.047432756 1.0 1.153786485366487 0.8934383113662815 23.868047148178643 -6.746630592443625 1.6621470395117248 1.090791041460894 0.8930453813736243 0.6344369676426218 0.06461430160756933 0.3059483482181339 1.6619191699868694 0.03072193475881208 0.07485521397206071 1.7921295775872678e-07 6.746630592443625 -0.19774566008726957 K(ub)GGSYSQAASSDSAQGSDVSLTACKV ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGGSYSQAASSDSAQGSDVSLTACKV 26 2 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913 Q53Z42 HLA-A 1 22913100.0 7231200.0 7006100.0 8675800.0 True False 6013063.196476492 6968356.748698025 10489869.66763311 1.0 1.158869701017164 1.7445134575967733 22.519668690466524 -6.946753596053589 0.5934253758156248 0.9932964027692538 1.9397289219903242 0.99892118369932 0.010515743088319776 0.08481632207450963 0.04156520369238654 0.010863945437726969 0.04911335676054196 1.1304371044000166e-07 6.946753596053589 0.9464325192210704 K(ub)GGSYSQAASSDSAQGSDVSLTACKV ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGGSYSQAASSDSAQGSDVSLTACKV 26 2 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913 Q53Z42 HLA-A 1 67620000.0 21206000.0 16313000.0 30101000.0 True False 27451585.032753292 15405167.209720511 24622926.862341963 1.0 0.561175873500206 0.8969582934086912 24.710386115914684 -9.78041877719939 6.071118835989262 1.0000000106816724 0.729067083453967 0.46468335609967215 0.13708259889717458 1.9817859502889672e-08 3.90931468173646e-09 0.13272966157861718 0.04424321854838068 1.6579873886516608e-10 9.78041877719939 -0.27093292722770546 K(ub)GGSYTQAASSDSAQGSDVSLTACK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGGSYTQAASSDSAQGSDVSLTACK 25 1 Q5SRN5;P04439;P04439-2;A0A1W2PS24;Q5SUL5;A0A0G2JIF2;A0A0G2JL56 Q5SRN5 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 1 22387600.0 9075200.0 7504400.0 5808000.0 True False 11897675.084361807 6384772.771922098 5207043.87427 1.0 0.5366403710514993 0.43765221670190757 23.504176349345112 -13.999999999999998 0.21692999197437013 3.7590702300987844 0.38312011111438615 0.999495009021865 0.0055082404507092566 12.917889135312256 0.14757281774584227 15.243606628778066 0.05591324442613223 1.0000000000000041e-14 13.999999999999998 -3.3759501189843983 K(ub)GGSYTQAASSDSAQGSDVSLTACK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGGSYTQAASSDSAQGSDVSLTACK 25 1 Q5SRN5;P04439;P04439-2;A0A1W2PS24;Q5SUL5;A0A0G2JIF2;A0A0G2JL56 Q5SRN5 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 1 8401100.0 3513400.0 2762200.0 2125500.0 True False 3401869.040137928 3865160.8646827084 1568767.7863668033 1.0 1.136187436693917 0.4611487884622384 21.69789617276516 -6.8542098649151315 1.2146295000655585 1.0730258983472283 0.4318945933001115 0.9462054023576029 0.06760221283074686 0.15288845709756493 0.4319470260029813 0.043499739495766784 0.10096864955192462 1.398911160820907e-07 6.8542098649151315 -0.6411313050471168 down K(ub)GGSYTQAASSDSAQGSDVSLTACK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGGSYTQAASSDSAQGSDVSLTACK 25 1 Q5SRN5;P04439;P04439-2;A0A1W2PS24;Q5SUL5;A0A0G2JIF2;A0A0G2JL56 Q5SRN5 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 1 17437900.0 6569500.0 6018600.0 4849800.0 True False 9966411.794782933 4944533.80646357 3891234.9042571485 1.0 0.49611975787031604 0.3904348911505015 23.248642754224363 -13.999999999999998 0.21952905261492733 4.034367222771998 0.3336480883161419 0.9994974246511796 0.005962441343858576 12.986824389481898 0.14843375065212233 17.079078299389703 0.058670707991011255 1.0000000000000041e-14 13.999999999999998 -3.7007191344558557 K(ub)GGSYTQAASSDSAQGSDVSLTACK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGGSYTQAASSDSAQGSDVSLTACK 25 1 Q5SRN5;P04439;P04439-2;A0A1W2PS24;Q5SUL5;A0A0G2JIF2;A0A0G2JL56 Q5SRN5 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 1 23958500.0 9075200.0 6360700.0 8522600.0 True False 12430546.688058468 6079663.241977911 6509737.408456667 1.0 0.4890905761866775 0.523688746104008 23.567386410868004 -10.2493872437767 7.211361620395769 1.0000019074104538 0.5063896611453427 0.9963288527661168 0.014124643721928409 4.3314799135571954e-07 4.5088537012016065e-08 0.01367618034633499 0.004558709158845157 5.6313530568524104e-11 10.2493872437767 -0.49361224626511113 K(ub)GGSYTQAASSDSAQGSDVSLTACK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGGSYTQAASSDSAQGSDVSLTACK 25 1 Q5SRN5;P04439;P04439-2;A0A1W2PS24;Q5SUL5;A0A0G2JIF2;A0A0G2JL56 Q5SRN5 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 1 10309600.0 3513400.0 2577200.0 4219000.0 True False 2921547.770010581 2563316.112065851 5101173.393548043 1.0 0.8773829195531407 1.7460516805205513 21.478301448199435 -6.871144565882232 1.1279688143203823 0.9301419606768492 1.7980562563310534 0.9658149574763897 0.07097469325083275 0.13576496039403518 0.32213490693312297 0.04879653726505186 0.11576773661688647 1.3454124250167217e-07 6.871144565882232 0.8679142956542042 K(ub)GGSYTQAASSDSAQGSDVSLTACK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGGSYTQAASSDSAQGSDVSLTACK 25 1 Q5SRN5;P04439;P04439-2;A0A1W2PS24;Q5SUL5;A0A0G2JIF2;A0A0G2JL56 Q5SRN5 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 1 16309800.0 6569500.0 3471900.0 6268400.0 True False 8504347.25420508 3278685.71295462 5127615.519215445 1.0 0.38553055454472807 0.6029405157086021 23.019769076316813 -10.148816254194161 5.205648568931147 1.0000187492916255 0.4942355351262796 0.8782813374136788 0.08875724497631199 1.9314325759727317e-05 3.1583792064134413e-06 0.08594201462374129 0.02864627763718199 7.098780469901197e-11 10.148816254194161 -0.5057832141653459 K(ub)GGSYTQAASSDSAQGSDVSLTACK(ub)V ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGGSYTQAASSDSAQGSDVSLTACKV 26 2 Q5SRN5;P04439;P04439-2;Q5SUL5;A0A0G2JIF2 Q5SRN5 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 2 24968400.0 8830500.0 8577800.0 7560100.0 True False 11576871.014683636 7298025.676002524 6777853.373599956 1.0 0.6303970793788756 0.5854650505307695 23.464742040026863 -13.999999999999998 0.29724649254603963 4.318601337934865 0.5740909685319778 0.9996436803822307 0.003505935717644739 16.411137763213826 0.17307001230592234 33.443251925968035 0.016432749389692764 1.0000000000000041e-14 13.999999999999998 -3.7445103694028874 K(ub)GGSYTQAASSDSAQGSDVSLTACK(ub)V ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGGSYTQAASSDSAQGSDVSLTACKV 26 2 Q5SRN5;P04439;P04439-2;Q5SUL5;A0A0G2JIF2 Q5SRN5 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 2 13838400.0 5457500.0 3855400.0 4525500.0 True False 5284254.649784473 5394881.3256454 3340135.7879101187 1.0 1.0209351522954027 0.632092132056193 22.333268561482146 -6.8941791750906685 0.9973119509251138 1.0188482617222008 0.5957732712876919 0.9834418341085158 0.022978452723610734 0.11581853426417794 0.20255508220421103 0.017451742978388432 0.044216685955834244 1.2759123023113508e-07 6.8941791750906685 -0.4230749904345089 K(ub)GGSYTQAASSDSAQGSDVSLTACK(ub)V ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGGSYTQAASSDSAQGSDVSLTACKV 26 2 Q5SRN5;P04439;P04439-2;Q5SUL5;A0A0G2JIF2 Q5SRN5 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 2 17512200.0 8985400.0 0.0 8526800.0 True False 13631508.720731016 0.0 6841474.242570791 1.0 0.0 0.5018867964458086 23.700441911127886 -9.47953911888737 10.46977087620227 1.0000000000370162 0.25094338461880755 0.7481108390379024 0.20489442665538657 0.0 0.0 0.19838817554175764 0.06612939184725253 3.314827103055023e-10 9.47953911888737 -0.7490566154182086 K(ub)GGSYTQAASSDSAQGSDVSLTACK(ub)V ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGGSYTQAASSDSAQGSDVSLTACKV 26 2 Q5SRN5;P04439;P04439-2;Q5SUL5;A0A0G2JIF2 Q5SRN5 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 2 25749400.0 8830500.0 10410000.0 6508900.0 True False 12095374.485289613 9950051.778733479 4971631.875003355 1.0 0.8226327999050154 0.41103579562996173 23.527952101549754 -6.957037463000328 0.47535600298819536 1.0103244157424385 0.20631787128768134 0.9996440298434667 0.004654536278675397 0.08077697789788725 0.025174792149717393 0.0057498540928507995 0.03396010192767768 1.1039833842601496e-07 6.957037463000328 -0.8040065444547572 down K(ub)GGSYTQAASSDSAQGSDVSLTACK(ub)V ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGGSYTQAASSDSAQGSDVSLTACKV 26 2 Q5SRN5;P04439;P04439-2;Q5SUL5;A0A0G2JIF2 Q5SRN5 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 2 21808000.0 8985400.0 5750800.0 7071800.0 True False 11631777.428713629 5430762.924640521 5784804.962795587 1.0 0.466890202974002 0.4973276868688619 23.471568233220335 -9.938265789640482 5.226347378802698 1.000001351410765 0.4821089449566039 0.9974160839299845 0.012426050781936569 34044386.295502655 0.0021429839872943654 599.3745801972682 0.004253767693811344 1.1527475566301232e-10 9.938265789640482 -0.5178924064541612 K(ub)GGSYTQAASSDSAQGSDVSLTACKV ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGGSYTQAASSDSAQGSDVSLTACKV 26 2 Q5SRN5;P04439;P04439-2;Q5SUL5;A0A0G2JIF2 Q5SRN5 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 1 43110000.0 17647000.0 13692000.0 11771000.0 True False 23135387.893791113 11649206.970997974 10553049.835404973 1.0 0.503523304838312 0.4561431986293653 24.463597951909104 -13.999999999999998 0.3322712746296014 6.479049076910171 0.44797370084787763 0.9997195367175188 0.004119276379434388 19.016808520009672 0.18445062301552273 72.89940180197488 0.015055461674388005 1.0000000000000041e-14 13.999999999999998 -6.031075376062294 K(ub)GGSYTQAASSDSAQGSDVSLTACKV ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGGSYTQAASSDSAQGSDVSLTACKV 26 2 Q5SRN5;P04439;P04439-2;Q5SUL5;A0A0G2JIF2 Q5SRN5 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 1 21911400.0 8822300.0 8812600.0 4276500.0 True False 8542240.915582877 12331517.137101889 3156356.3577500046 1.0 1.4435927596711258 0.3694998056062941 23.02618315599721 -6.7945761264407825 1.4781894878199777 1.246460499059375 0.3566240129567399 0.8157434309604711 0.1891727391989853 0.22860440186260383 0.9866569484933717 0.10071112150979618 0.2350086392059403 1.6048109299721727e-07 6.7945761264407825 -0.8898364861026351 down K(ub)GGSYTQAASSDSAQGSDVSLTACKV ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGGSYTQAASSDSAQGSDVSLTACKV 26 2 Q5SRN5;P04439;P04439-2;Q5SUL5;A0A0G2JIF2 Q5SRN5 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 1 56767000.0 22335000.0 12921000.0 21511000.0 True False 33883827.90721921 10615146.597766215 17259341.42139378 1.0 0.3132806194988547 0.5093681112019974 25.014093531526502 -10.344795010453254 5.2540284573536296 1.0002125251836842 0.4113243653505239 0.9231765689007267 0.08005238326927011 0.00019935745219936402 2.4861018912622687e-05 0.07753784957587133 0.0258367956021581 4.520692733774316e-11 10.344795010453254 -0.5888881598331603 K(ub)GGSYTQAASSDSAQGSDVSLTACKV ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGGSYTQAASSDSAQGSDVSLTACKV 26 2 Q5SRN5;P04439;P04439-2;Q5SUL5;A0A0G2JIF2 Q5SRN5 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 1 45550600.0 17647000.0 19003000.0 8900600.0 True False 24171572.792243488 18163384.62548246 6798461.593611032 1.0 0.7514357787802282 0.28125855326189686 24.526808013431996 -6.973041816527071 0.42225353481680317 1.020413039039198 3.0025320574831368e-12 0.999810821361213 0.004099277482611285 0.07755651328953772 0.01967960152866896 0.006039619168964638 0.038245346615412804 1.0640405609632974e-07 6.973041816527071 -1.0204130390361956 down K(ub)GGSYTQAASSDSAQGSDVSLTACKV ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGGSYTQAASSDSAQGSDVSLTACKV 26 2 Q5SRN5;P04439;P04439-2;Q5SUL5;A0A0G2JIF2 Q5SRN5 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 1 19669300.0 8822300.0 4524900.0 6322100.0 True False 7336133.3441579025 4500523.4655776685 7644021.879912319 1.0 0.613473509060688 1.0419687758265193 22.806588431431486 -6.669030881734619 1.9404392999602185 0.7530858347623931 1.0402449861746774 0.27496201317875835 0.16422296305148015 0.4633189652287574 3.3622605941881827 0.06815015263624577 0.18233505932069366 2.142738230254546e-07 6.669030881734619 0.2871591514122843 K(ub)GGSYTQAASSDSAQGSDVSLTACKV ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGGSYTQAASSDSAQGSDVSLTACKV 26 2 Q5SRN5;P04439;P04439-2;Q5SUL5;A0A0G2JIF2 Q5SRN5 HLA-A HLA class I histocompatibility antigen, A-3 alpha chain 1 63524000.0 22335000.0 17826000.0 23363000.0 True False 28913097.788670413 16833967.429686613 19111173.724623602 1.0 0.5822263512795574 0.6609867218071772 24.78521985361895 -10.82475998597865 7.28922162251945 1.0199793026752297 0.6216065365433673 0.9685295885943261 0.03215378662420123 0.009880904293212468 0.00023754632718946505 0.029465851462796632 0.010377590009419844 1.4970627833170836e-11 10.82475998597865 -0.39837276613186245 K(ub)GHAVGDIPGVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGHAVGDIPGVR 12 1 P62266;D6RD47 P62266 RPS23 40S ribosomal protein S23 1 6497300.0 1276000.0 2049100.0 3172200.0 True False 1672848.3568015792 1743382.267329242 2843971.1738910577 1.0 1.042163959596745 1.7000770944526136 20.67387524075783 -6.919948299662349 0.8250908388218563 0.9854578857105305 1.80605263347059 0.9941672234899435 0.02448077431566032 0.09820134155736779 0.10576456149898407 0.021087194897433752 0.06313683761699009 1.2024075660171965e-07 6.919948299662349 0.8205947477600595 K(ub)GIHYWEVELQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGIHYWEVELQK 12 1 Q14258 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 3634700.0 2124000.0 1510700.0 0.0 True False 2909300.1989417523 1443952.2787831554 0.0 1.0 0.4963228886824357 0.0 21.472240739320004 -7.94012652011212 0.5906840713975428 1.0111494802053196 1.6541502060082441e-18 0.9890898110684407 0.04264267311972664 0.11219617362588195 0.16209089172660615 0.04506018988519227 0.0768844406515204 1.1478191862840094e-08 7.94012652011212 -1.0111494802053196 K(ub)GILLQLFGGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGILLQLFGGTR 12 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 5873600.0 1950800.0 2047200.0 1875600.0 True False 1888872.9218139336 2864657.6360069676 1384324.0932061058 1.0 1.5165962743835422 0.7328836562899654 20.849094213752497 -6.728930297579818 1.727036065885482 1.3112618414681136 0.7334355665227689 0.554272244070126 0.21718495379328143 0.3382822130128005 1.9761709139156198 0.09967424168980804 0.2476438906280987 1.8666792608889787e-07 6.728930297579818 -0.5778262749453448 K(ub)GILLQLFGGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGILLQLFGGTR 12 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 13121500.0 4227400.0 0.0 8894100.0 True False 6413274.864337523 0.0 7136177.23657748 1.0 0.0 1.1127196927516425 22.61262980979457 -10.678375268723768 4.309588230622771 1.0182373062234324 0.5563598463756607 0.1748819442424483 0.4542659123318734 0.08023603515032446 0.005988014284814635 0.44336048872550315 0.1466136927675134 2.0971269978615616e-11 10.678375268723768 -0.46187745984777173 K(ub)GIVDQSQQAYQEAFEISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGIVDQSQQAYQEAFEISK 19 1 P63104;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 1 36324000.0 15721000.0 13146000.0 7457000.0 True False 15221945.460240329 18395266.355484366 5503787.9947952265 1.0 1.2084701264718587 0.3615692888383487 23.859649420324743 -6.841585348123822 1.2748824813643247 1.1108955622177328 0.3328069398296842 0.9271583644817567 0.0972399602448161 0.16696194131785802 0.5264269097124358 0.059789383732596374 0.13781732676927483 1.4401729577470962e-07 6.841585348123822 -0.7780886223880485 down K(ub)GIVLLEELLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGIVLLEELLPK 12 1 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 5867300.0 710360.0 4221000.0 935940.0 True False 931288.8391360256 3591243.2533291345 839097.9069704307 1.0 3.856207765424097 0.901007154503084 19.82886916333978 -6.653950726207001 1.9947030770850507 2.847597363476588 0.9134847176594837 0.21014492358863457 1.2178892374627523 0.4989034150546448 3.809384550696545 0.49444090090740667 1.3490828858760051 2.2184481042133995e-07 6.653950726207001 -1.934112645817104 K(ub)GIVLLEELLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGIVLLEELLPK 12 1 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 5463200.0 710360.0 3754900.0 997940.0 True False 972999.2887571867 3588996.102206183 762247.1252194446 1.0 3.6885906738846774 0.7833994680438707 19.89207922486267 -6.663553676515544 1.9604308935529617 2.7255189342205677 0.7954523801854289 0.250808843268304 1.1437738327402505 0.4760412204288001 3.5207473803773492 0.4707755921151213 1.2683680355043345 2.169932994679952e-07 6.663553676515544 -1.9300665540351387 K(ub)GLTPSQIGVILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGLTPSQIGVILR 13 1 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 1 15733200.0 2763700.0 5680100.0 7289400.0 True False 2675967.8562728935 7948193.551330196 5380087.462687446 1.0 2.9702126401475146 2.0105202123693924 21.35162935575414 -10.04077674934022 5.8122892738286245 0.9999960372395078 2.4903664262586895 0.7627853003551465 0.3917927930123696 2.011997472930292e-05 3.3193539316477657e-06 0.37935274572663613 0.12645058020829433 9.103811371066508e-11 10.04077674934022 1.4903703890191817 K(ub)GLTPSQIGVILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGLTPSQIGVILR 13 1 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 1 6529200.0 2059700.0 2481000.0 1988500.0 True False 2821226.751299591 2371381.21643014 1518857.2544430192 1.0 0.8405496705777973 0.5383676635503905 21.427891194066767 -6.961084514803056 0.41987415995595384 1.0133750976660827 0.35414560781214466 0.9998083201130258 0.0026504491901282487 0.07931602463803392 0.019716902118815095 0.00390866910969959 0.025155207176632208 1.0937435003130608e-07 6.961084514803056 -0.659229489853938 K(ub)GLTPSQIGVILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGLTPSQIGVILR 13 1 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 1 9585100.0 2763700.0 5129200.0 1692200.0 True False 2298139.002669276 5101567.981533514 2046031.1961512181 1.0 2.2198691966012807 0.8902991480388105 21.132034631188418 -6.665388096533589 1.9534352135461737 1.7816794240963245 0.8957333821571802 0.2589391341247438 0.5187261954687648 0.4717724184140296 3.466004288349338 0.21410675630076312 0.5755619261974015 2.1607867270325756e-07 6.665388096533589 -0.8859460419391443 K(ub)GLTPSQIGVILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGLTPSQIGVILR 13 1 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 1 10501400.0 2588900.0 2372400.0 5540100.0 True False 3351382.084848391 2240373.8544927975 4531858.646226397 1.0 0.6684925197343313 1.3522357437890906 21.676324744225948 -6.774883748744899 1.5559274019885576 0.8110435180324453 1.3567964549396354 0.7488274954653606 0.13991683449845335 0.25860613809362526 1.2361859685003234 0.07085645605142364 0.167912077683736 1.6792534578578322e-07 6.774883748744899 0.5457529369071901 K(ub)GNFILSAGVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGNFILSAGVDK 12 1 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 1 18951700.0 7691900.0 10110300.0 1149500.0 True False 10084155.388465557 8601882.649640739 1030560.7667826028 1.0 0.8530097284577478 0.10219604191753899 23.265586918425175 -7.065506271811725 0.7549120758223002 1.0013547362414372 1.0856580103635978e-19 0.9969783085148278 0.02161357243550486 0.07724479601829311 0.07297870025013832 0.02015033773098453 0.054479061037008586 8.59990647347285e-08 7.065506271811725 -1.0013547362414372 down K(ub)GNFILSAGVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGNFILSAGVDK 12 1 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 1 40191000.0 16798400.0 19831000.0 3561600.0 True False 16265143.986979257 27749621.71729883 2628710.114290286 1.0 1.7060790694206733 0.16161616007793403 23.95528025808652 -6.782403692154556 1.5264917544130667 1.3985515266874846 0.14844385207511882 0.7758069691842564 0.2989120533290288 0.24685803275469329 1.1363066850229966 0.15420508604971597 0.36313718061730504 1.6504269544878125e-07 6.782403692154556 -1.2501076746123658 K(ub)GNFILSAGVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGNFILSAGVDK 12 1 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 1 27907300.0 11119000.0 6455300.0 10333000.0 True False 16868335.907784667 5303301.279510888 8290678.020885221 1.0 0.3143938624712493 0.49149353357725745 24.007814320350157 -10.725406419284054 10.358796318626586 1.0008541936009845 0.402943698027006 0.9380966988171111 0.07230063797074023 0.0014277443758042901 3.784702150406988e-05 0.07007584436425762 0.023334930565070692 1.881887166990756e-11 10.725406419284054 -0.5979104955739785 K(ub)GNFILSAGVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGNFILSAGVDK 12 1 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 1 20873900.0 7691900.0 11844700.0 1337300.0 True False 10535803.295781579 11321361.988815028 1021457.2825580336 1.0 1.0745608731465193 0.09695105858392535 23.328796979948066 -6.888501586110714 1.0312305395925023 1.05443073643836 0.015302690345821992 0.9799208583560248 0.06296045504022413 0.12036631705365868 0.22902894928167983 0.0466095872430938 0.11558635681058248 1.2927019796502902e-07 6.888501586110714 -1.039128046092538 down K(ub)GNFILSAGVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGNFILSAGVDK 12 1 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 1 38631400.0 16798400.0 20351800.0 1481200.0 True False 13968613.895299623 20242160.813883983 1790912.0717049907 1.0 1.4491173544925156 0.1282097196707273 23.735685533520797 -6.814929702883799 1.3935311332371605 1.2433694774531037 0.10234803716339971 0.8723902030717502 0.19589642402723725 0.20012466334974385 0.7649301339080383 0.11050340634357134 0.255116919292221 1.5313353113532002e-07 6.814929702883799 -1.1410214402897039 down K(ub)GNFILSAGVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGNFILSAGVDK 12 1 Q9BZK7;A0A0D9SF63;A0A1B0GVH3 Q9BZK7 TBL1XR1 F-box-like/WD repeat-containing protein TBL1XR1 1 28143800.0 11119000.0 10975000.0 6049800.0 True False 14393764.688257284 10364231.602199642 4948798.476190034 1.0 0.7200500929860959 0.3438154355981213 23.778940642442606 -6.967018777237143 0.3215293492538814 1.050609266055159 0.001093715178710145 0.999948912028281 0.001921589649308544 0.07728246438457353 0.012479124223538713 0.005668068141684962 0.03305001122889274 1.0789000736967637e-07 6.967018777237143 -1.0495155508764489 down K(ub)GNFNYIEFTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGNFNYIEFTR 11 1 J3QRS3;P19105;O14950 J3QRS3 MYL12A;MYL12B Myosin regulatory light chain 12A;Myosin regulatory light chain 12B 1 13801900.0 3494900.0 6288700.0 4018300.0 True False 4581847.744659741 5350450.473160607 3602524.862255355 1.0 1.1677495131514772 0.7862602738063892 22.12749808783714 -6.787197897148573 1.5076989158534349 1.0940981444161533 0.7825207385880689 0.7920586945001564 0.07119122557080224 0.23955492198159942 1.075830132772707 0.03717418314882734 0.08720781127615979 1.6323079764258568e-07 6.787197897148573 -0.31157740582808435 K(ub)GNFNYIEFTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGNFNYIEFTR 11 1 J3QRS3;P19105;O14950 J3QRS3 MYL12A;MYL12B Myosin regulatory light chain 12A;Myosin regulatory light chain 12B 1 18319000.0 4366700.0 4280200.0 9672100.0 True False 4228081.498710734 5989306.180948137 7138686.853219643 1.0 1.4165540997198025 1.6883985929307272 22.01157175509222 -8.624703897180561 0.09199558263439407 5.291219055169517e-07 2.654596879973214 0.9999820962677609 0.001197860584248906 0.21600666079138944 0.02435828901321102 0.3622166048076614 0.31312982981535087 2.372991064146398e-09 8.624703897180561 2.6545963508513086 K(ub)GNFNYIEFTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGNFNYIEFTR 11 1 J3QRS3;P19105;O14950 J3QRS3 MYL12A;MYL12B Myosin regulatory light chain 12A;Myosin regulatory light chain 12B 1 45748300.0 9125300.0 16361000.0 20262000.0 True False 13843747.248791017 13441251.720923549 16257206.818849936 1.0 0.9709258251661147 1.1743357146505031 23.722731171168153 -6.8706622048962025 1.130640767157036 0.9834902911946474 1.186396494497751 0.9653368841786893 0.016723308370380816 0.13621869511539428 0.3250615490304614 0.011474675993167817 0.027197353324960646 1.346907574103451e-07 6.8706622048962025 0.2029062033031036 K(ub)GNFNYIEFTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGNFNYIEFTR 11 1 J3QRS3;P19105;O14950 J3QRS3 MYL12A;MYL12B Myosin regulatory light chain 12A;Myosin regulatory light chain 12B 1 17719500.0 3494900.0 3321600.0 10903000.0 True False 4787058.976121248 3174840.7289376697 8327935.9543335335 1.0 0.6632132055975022 1.7396769072357052 22.19070814936003 -6.822626016700047 1.3604426748818936 0.8189394341853328 1.764533560228638 0.8903229531374659 0.1488988453090636 0.19009104994246714 0.6905766872675203 0.08599086780025142 0.19807306201302372 1.5044369217649286e-07 6.822626016700047 0.9455941260433053 K(ub)GNFNYIEFTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGNFNYIEFTR 11 1 J3QRS3;P19105;O14950 J3QRS3 MYL12A;MYL12B Myosin regulatory light chain 12A;Myosin regulatory light chain 12B 1 18064800.0 4366700.0 7231200.0 6466900.0 True False 3631104.527610066 7192244.090319179 7819098.890432763 1.0 1.9807317678769765 2.153366511753702 21.791977030526496 -10.78103168856989 0.33836279852591195 4.521624490982004e-25 2.1882242998634345 0.9992481252899961 0.01392747673345322 2.4567496143358345 0.16661332319187033 2.0435926180332937 0.05342554104174086 1.6556491535807886e-11 10.78103168856989 2.1882242998634345 K(ub)GNFNYIEFTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGNFNYIEFTR 11 1 J3QRS3;P19105;O14950 J3QRS3 MYL12A;MYL12B Myosin regulatory light chain 12A;Myosin regulatory light chain 12B 1 42841300.0 9125300.0 16088000.0 17628000.0 True False 11812880.736554915 15192688.657511434 14419884.878554316 1.0 1.2861120836086761 1.2206916500843048 23.493857493260602 -10.109355364917555 4.3352369707064975 0.9999661790951765 1.2534018668664253 0.9523915507221551 0.02670778022898145 14066434.146264398 0.4035390086193077 4898.536007272425 0.00977404673972863 7.774001768320331e-11 10.109355364917555 0.2534356877712488 K(ub)GQDSIEPVPGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGQDSIEPVPGQK 13 1 Q9NR50;Q9NR50-3;Q9NR50-2 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 3315770.0 682260.0 979010.0 1654500.0 True False 894449.4670152375 832945.5241510904 1483308.2110846594 1.0 0.9312382139715676 1.6583476940675401 19.77064045224684 -6.883724450865865 1.058763585182095 0.9548548325057422 1.713713902464527 0.976569429246461 0.05017034029633456 0.12438410916714193 0.25275949134248266 0.03637002311179058 0.0888498391019769 1.3069998842963558e-07 6.883724450865865 0.7588590699587847 K(ub)GQDSIEPVPGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGQDSIEPVPGQK 13 1 Q9NR50;Q9NR50-3;Q9NR50-2 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 7627560.0 917860.0 1756900.0 4952800.0 True False 888723.0367111635 2458439.3321124665 3655513.0991848935 1.0 2.766260387724667 4.113219696332617 19.761374359387506 -7.745090090355888 0.20991100003425664 2.865580621536242e-17 5.858717617753409 0.999873584801146 0.014333188211433224 0.13337858541760436 0.029202388790917237 0.2542807937111386 0.42933481033277576 1.798497794769586e-08 7.745090090355888 5.858717617753409 K(ub)GQDSIEPVPGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGQDSIEPVPGQK 13 1 Q9NR50;Q9NR50-3;Q9NR50-2 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 6318160.0 917860.0 2424200.0 2976100.0 True False 763241.2580924217 2411140.3534339736 3598388.7500683437 1.0 3.1590802093956065 4.714615086534815 19.541779634821783 -7.997842039135732 0.23772616342356223 1.8417123909459492e-17 6.252276831377133 0.9996612458952457 0.028033863375730456 0.10564994717398028 0.04441315804166694 0.3798534841049735 0.5293552645621006 1.0049812539161555e-08 7.997842039135732 6.252276831377133 K(ub)GQGGAGAGDDEEED ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGQGGAGAGDDEEED 15 1 P46781 P46781 RPS9 40S ribosomal protein S9 1 19589100.0 7168600.0 6935300.0 5485200.0 True False 9398104.020821141 5900580.273587663 4917644.121753751 1.0 0.6278479425759869 0.5232591713029456 23.163938305300306 -13.999999999999998 0.17805091844719778 2.919589913801618 0.43848545449996673 0.9995006179976373 0.004571965062375518 12.180151287244218 0.1337453526329835 8.085246222354808 0.0794028144413886 1.0000000000000041e-14 13.999999999999998 -2.4811044593016516 K(ub)GQGGAGAGDDEEED ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGQGGAGAGDDEEED 15 1 P46781 P46781 RPS9 40S ribosomal protein S9 1 12807500.0 5037300.0 5280800.0 2489400.0 True False 4877393.6687786095 7389450.979008205 1837351.4596008072 1.0 1.5150409175109012 0.3767076402633118 22.217678990554592 -6.783689732767221 1.5213925734132843 1.2902319936524749 0.3666083247014982 0.7802592552638792 0.21817385040504383 0.24488458531582394 1.1197448239094834 0.11291992000420563 0.26564534061762035 1.645546909579696e-07 6.783689732767221 -0.9236236689509767 down K(ub)GQGGAGAGDDEEED ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGQGGAGAGDDEEED 15 1 P46781 P46781 RPS9 40S ribosomal protein S9 1 19225500.0 7168600.0 6365700.0 5691200.0 True False 9819025.144130807 6084442.325445116 4347055.7739432305 1.0 0.6196584931939003 0.4427176537521778 23.227148366823197 -13.999999999999998 0.1023657893509262 2.8660059755728526 0.07930228737889793 0.9997818159155702 0.00343435412228773 12.062801931353128 0.09575227748308542 4.72755294173025 0.3237071061869209 1.0000000000000041e-14 13.999999999999998 -2.786703688193955 K(ub)GQGGAGAGDDEEED ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGQGGAGAGDDEEED 15 1 P46781 P46781 RPS9 40S ribosomal protein S9 1 10577400.0 5037300.0 4052000.0 1488100.0 True False 4188738.140227211 4030171.071740975 1799254.829802997 1.0 0.9621444303325118 0.42954578910616725 21.99808426598887 -6.921227188826627 0.8155765103757424 1.0112398477543734 0.34118835941911096 0.9945149736902601 0.019289248813092397 0.0974552113213611 0.10191318453257481 0.016728539496320822 0.050712940418021595 1.198871983244739e-07 6.921227188826627 -0.6700514883352624 down K(ub)GQGGECEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGQGGECEIR 10 1 Q9BW19 Q9BW19 KIFC1 Kinesin-like protein KIFC1 1 8913200.0 3402800.0 5038000.0 472400.0 True False 4461103.752762073 4286350.037970186 423520.57958077523 1.0 0.9608272471395249 0.0949362765478284 22.08896927086644 -6.954152508203018 0.8916720715682872 1.01872601134588 1.7554809807504904e-17 0.9929975934453485 0.0349553257805943 0.0911429881169477 0.12272626959987391 0.029523800381722507 0.07572735867036956 1.1113413966442577e-07 6.954152508203018 -1.01872601134588 down K(ub)GQSPLDLCPDPNLCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGQSPLDLCPDPNLCK 16 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 136353000.0 19218000.0 42727000.0 74408000.0 True False 25194984.10737673 36352298.14854154 66708973.93193559 1.0 1.4428387012912667 2.6477085140293526 24.5866332104888 -6.953623821074036 0.5175337720859841 0.9791289026106578 3.164961528479348 0.9994558382657884 0.0162413982155962 0.08206241584686995 0.03018657856617948 0.01847250824061342 0.09949969241430584 1.1126951086743858e-07 6.953623821074036 2.1858326258686906 up K(ub)GQSPLDLCPDPNLCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGQSPLDLCPDPNLCK 16 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 50305100.0 24252000.0 18140000.0 7913100.0 True False 23482133.53487364 25383396.598850332 5840421.722088516 1.0 1.0809663679474908 0.24871767777893034 24.485060158704883 -6.883006764815846 1.0628464853372452 1.0524971745908602 0.1862173922844782 0.9760326346106379 0.058009201868121245 0.12500185440020714 0.25645224100898983 0.04192196858349319 0.1022023505402434 1.3091615306020552e-07 6.883006764815846 -0.866279782306382 down K(ub)GQSPLDLCPDPNLCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGQSPLDLCPDPNLCK 16 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 165710000.0 34545000.0 70154000.0 61011000.0 True False 52407290.5777877 57634470.58429615 48952149.10792871 1.0 1.099741466289882 0.9340713585501896 25.64326418873725 -6.743681619724319 1.6731224723190357 1.0590916818634233 0.9338925238249269 0.6213683732331974 0.041905533173803446 0.31120838320975674 1.711885498205054 0.01980272910580385 0.048400910202477616 1.804340013594735e-07 6.743681619724319 -0.12519915803849635 K(ub)GQSPLDLCPDPNLCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGQSPLDLCPDPNLCK 16 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 135137000.0 19218000.0 26875000.0 89044000.0 True False 26323413.946922135 25687573.63625959 68013641.11874488 1.0 0.9758450666032666 2.5837697669415474 24.64984327201169 -6.903490267999609 0.9389334336446723 0.9393985287216005 2.765043953696192 0.9882243269159108 0.08164230089014218 0.10888174374208744 0.16328248451608768 0.06476095023296957 0.1716490223488644 1.2488484294203564e-07 6.903490267999609 1.8256454249745917 up K(ub)GQSPLDLCPDPNLCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGQSPLDLCPDPNLCK 16 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 78044200.0 24252000.0 4045200.0 49747000.0 True False 20166612.545766667 4023407.7046906627 60148867.69586027 1.0 0.19950835548408688 2.9825964851239526 24.26546543413916 -6.829795793432711 1.3288534663783094 0.5722128183527574 3.05715920596324 0.9054603804570854 0.3596989042326395 0.18106310908216183 0.6253874703930096 0.21253659767164262 0.48910266294299704 1.4798040329005946e-07 6.829795793432711 2.4849463876104827 K(ub)GQSPLDLCPDPNLCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGQSPLDLCPDPNLCK 16 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 123286000.0 34545000.0 70049000.0 18692000.0 True False 44719183.483752854 66150711.57198017 15290247.79611628 1.0 1.479246856016808 0.3419169717548947 25.414390510829698 -6.792219994509301 1.4874036848519947 1.2670732473110384 0.32905967748011167 0.8084742006554266 0.20403599678238496 0.23204391746979472 1.0141015938526006 0.10795970621692283 0.2523627543963533 1.613541000774484e-07 6.792219994509301 -0.9380135698309268 down K(ub)GQSPLDLCPDPNLCK(ub)ALAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGQSPLDLCPDPNLCKALAK 20 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 45138100.0 5761100.0 9811000.0 29566000.0 True False 7552857.890571768 8347237.042978468 26506793.937098242 1.0 1.10517596966816 3.509505186134466 22.848591211696107 -6.91606897455889 0.8533683371638654 0.9390694059123728 3.8642184215336717 0.9930175600826874 0.09684698595488982 0.10054038601789111 0.11800623876997501 0.08175093892515486 0.23639260392903574 1.213196155603513e-07 6.91606897455889 2.925149015621299 up K(ub)GQSPLDLCPDPNLCK(ub)ALAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGQSPLDLCPDPNLCKALAK 20 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 85271000.0 10597000.0 27696000.0 46978000.0 True False 16076423.744472882 22753432.410164338 37692777.70881111 1.0 1.4153292281803054 2.3445996639501363 23.938443173965965 -6.957793496445529 0.46549538276056296 0.9743498173000981 2.823386586885448 0.9996793862359682 0.01006546401406622 0.08049904327059695 0.02411709326949888 0.012742584587743659 0.07672534493299431 1.102063207222299e-07 6.957793496445529 1.84903676958535 up K(ub)GQSPLDLCPDPNLCK(ub)ALAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGQSPLDLCPDPNLCKALAK 20 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 69798100.0 5761100.0 17771000.0 46266000.0 True False 7891134.357873519 16985818.459161647 35338923.67817994 1.0 2.1525192309282817 4.478307183164345 22.911801273218998 -6.9598691431687945 0.4372738154003328 0.9144360431363896 5.806660295988047 0.9997653161519037 0.022162416108158157 0.07974789851003358 0.021304259336916202 0.030563529679079028 0.1928086322588237 1.0968086246578023e-07 6.9598691431687945 4.8922242528516575 K(ub)GQTHTLEDFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGQTHTLEDFQR 12 1 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 1 17001000.0 2681300.0 4091700.0 10228000.0 True False 2596183.599169415 5725537.147933616 7548979.9665771155 1.0 2.205366812179755 2.907721922668422 21.307960982031442 -8.800395456218707 0.19572704882075245 1.2506970861801778e-19 3.7099488968162917 0.999646786222903 0.014805838925383412 0.3292872497320621 0.05940957637145404 0.5829204670206578 0.37620771460958774 1.5834506905906166e-09 8.800395456218707 3.7099488968162917 K(ub)GSQITQQSTNQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGSQITQQSTNQSR 14 1 P50750;P50750-2 P50750 CDK9 Cyclin-dependent kinase 9 1 7475800.0 1532200.0 2400000.0 3543600.0 True False 2008729.0378459047 2041929.3551267257 3176942.264611422 1.0 1.0165280217766075 1.5815683473258648 20.93785153801431 -6.913152657051876 0.8739953713131524 0.9842006280093765 1.6597360089185142 0.992057679315761 0.024092839277405288 0.10237027514295621 0.12773415993276926 0.020037838153041335 0.05659935121079824 1.2213702659060822e-07 6.913152657051876 0.6755353809091378 K(ub)GSQITQQSTNQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGSQITQQSTNQSR 14 1 P50750;P50750-2 P50750 CDK9 Cyclin-dependent kinase 9 1 11168600.0 1606200.0 2167400.0 7395000.0 True False 1555212.0601894287 3032854.1228416874 5458027.654755352 1.0 1.9501225591526588 3.5095070276721945 20.568679881078562 -6.963718910334104 0.37940181767330533 0.8921622928233756 4.622558367554686 0.9998842459476346 0.01113027486989499 0.0783984781341899 0.01640993546275063 0.020306532548736853 0.1318043878723489 1.08712902160295e-07 6.963718910334104 3.7303960747313103 K(ub)GSQITQQSTNQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGSQITQQSTNQSR 14 1 P50750;P50750-2 P50750 CDK9 Cyclin-dependent kinase 9 1 9772500.0 1532200.0 2233500.0 6006800.0 True False 2098695.7461480936 2134816.584803191 4588117.553929255 1.0 1.0172110887065897 2.1861756580724956 21.001061599537202 -6.9101032650684155 0.8950161175404084 0.9639242324519915 2.3375865223366112 0.9909607769874073 0.052781393700277776 0.10435032387547112 0.13839167162072163 0.04323483520706932 0.11943560443839805 1.2299762764536983e-07 6.9101032650684155 1.3736622898846198 up K(ub)GSQITQQSTNQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGSQITQQSTNQSR 14 1 P50750;P50750-2 P50750 CDK9 Cyclin-dependent kinase 9 1 11132500.0 1606200.0 4001900.0 5524400.0 True False 1335626.4667248232 3980340.9703850416 6679526.498060397 1.0 2.9801303504755303 5.001043828099408 20.34908515651284 -6.970870801728673 0.23646536483756117 0.2417825526909411 7.797589671353488 0.9999884003874087 0.005563226120175587 0.07602113675791616 0.008012174990262163 0.0495403863200003 0.19828146760651227 1.0693729596837486e-07 6.970870801728673 7.555807118662547 K(ub)GSVDQYLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGSVDQYLLR 10 1 Q8NCN4;H0YEQ1 Q8NCN4 RNF169 E3 ubiquitin-protein ligase RNF169 1 5394130.0 942230.0 1438200.0 3013700.0 True False 912319.4244006255 2012480.7601139208 2224321.5609379606 1.0 2.205894894144206 2.4380951467730645 19.79917950860234 -10.50302180460758 0.3430480936516406 1.7921351251234229e-16 2.484824771350636 0.999129879039289 0.01859432757797346 2.0206737325372655 0.16397771204336747 1.8324239610653825 0.07055690842237575 3.1403510224262545e-11 10.50302180460758 2.484824771350636 K(ub)GSVDQYLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGSVDQYLLR 10 1 Q8NCN4;H0YEQ1 Q8NCN4 RNF169 E3 ubiquitin-protein ligase RNF169 1 4810330.0 942230.0 2571300.0 1296800.0 True False 783505.9928664734 2557447.8965369132 1567954.8842742615 1.0 3.264107639024477 2.0012034350086654 19.579584784036616 -10.23546884708767 5.892370800660887 0.9999489502646064 2.632655537016584 0.6902460366727965 0.5155784823091256 0.00034577457475565244 4.4863559450294786e-05 0.49922208242010385 0.16640223963717168 5.814751413219575e-11 10.23546884708767 1.6327065867519774 K(ub)GTVEGFEPADNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGTVEGFEPADNK 13 1 P37108;H0YLA2 P37108 SRP14 Signal recognition particle 14 kDa protein 1 9954400.0 3274700.0 4542900.0 2136800.0 True False 4293163.412239916 3865117.0280855014 1915704.433632943 1.0 0.9002958091615979 0.4462221093590852 22.033609656980932 -6.9419080762148395 0.6415681876270005 1.0049765905625305 0.3165794387443894 0.9984032774694412 0.009630716738435914 0.08690687552532052 0.050726100817455065 0.0095163088703875 0.03876455154826577 1.1431202646923006e-07 6.9419080762148395 -0.6883971518181411 down K(ub)GTVEGFEPADNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGTVEGFEPADNK 13 1 P37108;H0YLA2 P37108 SRP14 Signal recognition particle 14 kDa protein 1 9658000.0 3274700.0 4069400.0 2313900.0 True False 4485445.085440006 3889600.452293755 1767404.476266382 1.0 0.8671604218095559 0.394031014224981 22.096819718503824 -6.947543206273223 0.5851937716463834 1.0055523128181003 0.23202762894505496 0.9989941183743449 0.008248070650316032 0.08448751490827033 0.04016257476303276 0.008594022074835346 0.03958067589803402 1.1283836734292235e-07 6.947543206273223 -0.7735246838730454 down K(ub)GVAINFVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGVAINFVK 9 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 4400400.0 1176200.0 1794200.0 1430000.0 True False 1542009.5903370013 1526512.3537368234 1282037.3175285961 1.0 0.9899499739189099 0.8314068379097506 20.556380307267528 -6.919822309994241 0.826049355526502 1.0035206117739879 0.8059450165879041 0.9941312889992046 0.005915311180906373 0.09827643599575112 0.106158773917022 0.005091851307158402 0.015226571957056007 1.2027564373764178e-07 6.919822309994241 -0.1975755951860838 K(ub)GVAINFVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGVAINFVK 9 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 8078500.0 1742000.0 2066400.0 4270100.0 True False 1686701.1635225888 2891524.2961336393 3151632.7097458853 1.0 1.7143074058802683 1.8685187263189302 20.685772960202854 -11.12768168236136 0.2838179373255605 7.2461724928866715e-12 1.9215199313096631 0.999259152337067 0.010298134156144383 3.145775319108042 0.14886867838113066 2.0773380876093674 0.059648651920912885 7.452780278668905e-12 11.12768168236136 1.921519931302417 K(ub)GVAINFVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGVAINFVK 9 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 3573000.0 1176200.0 0.0 2396800.0 True False 1611072.9256098343 0.0 1830725.2036454761 1.0 0.0 1.1363391281325752 20.61959036879042 -10.692092216790078 4.410484715156113 1.0189360978026683 0.5681695640753456 0.16146253997340487 0.46390850644756676 0.0869451658235134 0.006069871082558475 0.45211866443484894 0.14972582663624742 2.031925512146278e-11 10.692092216790078 -0.45076653372732267 K(ub)GVAINFVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGVAINFVK 9 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 5893500.0 1742000.0 2690000.0 1461500.0 True False 1448550.183684871 2675508.4360768064 1767092.8927874991 1.0 1.8470250228202363 1.219904503613612 20.46617823563713 -10.351484482165647 5.268117504186222 0.9997955204940849 1.5334647632169496 0.49104861571781777 0.25602087988100375 0.000615100675123506 7.571980484894034e-05 0.24798462100500027 0.08263038367169516 4.451593686850246e-11 10.351484482165647 0.5336692427228646 K(ub)GVAINMVTEEDK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 2 17548400.0 6307800.0 7746600.0 3494000.0 True False 8269586.884822097 6590837.476010299 3132474.3968146285 1.0 0.7969971859304176 0.3787945444486393 22.97938382930052 -6.959462000545235 0.4429541409340378 1.0145008366057149 0.14490563838450593 0.9997497128867295 0.004091624163752469 0.07989392081851894 0.02184597548137151 0.0055346465842465225 0.03463193433263074 1.0978373435214529e-07 6.959462000545235 -0.8695951982212089 down K(ub)GVAINMVTEEDK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 2 116709300.0 11318000.0 6105300.0 99286000.0 True False 17170233.456633423 5015761.514073377 79662078.58140023 1.0 0.2921195874675556 4.639545454207215 24.033406319418653 -6.865134829756472 1.1594362225124877 0.6092647920876952 4.8717670776109046 0.9595865553403907 0.3828834797407295 0.14160963617614264 0.3588483588585648 0.2569611787569096 0.6037689176680134 1.3641595579742312e-07 6.865134829756472 4.262502285523209 up K(ub)GVAINMVTEEDK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 2 17415900.0 6307800.0 7484200.0 3623900.0 True False 8639964.1218855 7153523.297060244 2768009.456563268 1.0 0.8279575234508183 0.3203727952471178 23.04259389082341 -6.951825204219369 0.5384323480492622 1.0075509866324452 0.11740188251102596 0.9993368489790464 0.007429585617967645 0.08276098810734474 0.032992327121643045 0.008189407391083791 0.04202485896704132 1.1173128557851424e-07 6.951825204219369 -0.8901491041214193 down K(ub)GVAINMVTEEDK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 2 26055800.0 7688400.0 13104000.0 5263400.0 True False 6393245.253870705 13033406.151059667 6363952.604788052 1.0 2.0386213313447916 0.9954181878029912 22.60811700803632 -6.647209092956822 2.0184857775517577 1.6754629386400526 0.9998026477314348 0.18272049986513106 0.443604880612191 0.5154755517845878 4.0223276025330765 0.17843249114928905 0.4912964480682662 2.2531541601556365e-07 6.647209092956822 -0.6756602909086178 K(ub)GVAINMVTEEDKR ddPTM_RPMI8226_Bortezomib_1h_R1 2 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 75205000.0 21311700.0 34977000.0 18916300.0 True False 27939845.08279641 29758567.939278122 16959022.733962383 1.0 1.0650942355296582 0.6069834204057444 24.735820685714067 -6.870886282789551 1.1293411606718993 1.0370231956516138 0.5796919234251255 0.9655625468397053 0.037553566335289536 0.13601080032900217 0.3236646696808712 0.025791659483986273 0.06116110548164555 1.3462128050551954e-07 6.870886282789551 -0.4573312722264883 K(ub)GVAINMVTEEDKR ddPTM_RPMI8226_Bortezomib_2h_R1 2 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 105994080.0 25540000.0 35587080.0 44867000.0 True False 24729246.679889202 49797186.62817053 33114986.7188517 1.0 2.0136960608940653 1.3391021225803095 24.559714956194078 -10.484594746425863 4.877550913695208 0.9979284870685741 1.6763990917372482 0.5727369685851795 0.27540182207408626 0.006219401423549448 0.0006571966347134489 0.2673271496736062 0.08888555586731278 3.276462891335254e-11 10.484594746425863 0.6784706046686741 K(ub)GVAINMVTEEDKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 325439300.0 29306000.0 24380000.0 271753300.0 True False 44459344.5555839 20029198.518190548 218041141.14129746 1.0 0.4505059334185566 4.904281503041466 25.405983343719512 -6.876006749637988 1.101766952244351 0.6744600809659331 5.196783614577476 0.9703219549775026 0.3415736452412113 0.13122905358844242 0.29412713342182256 0.23960441398406568 0.5740113432674472 1.3304337407273466e-07 6.876006749637988 4.522323533611543 up K(ub)GVAINMVTEEDKR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 70246900.0 21311700.0 28781700.0 20153500.0 True False 29191211.41703722 27510029.325645864 15393658.374361264 1.0 0.9424079368487549 0.5273387991488725 24.79903074723696 -6.932092575636484 0.7294181573569808 1.0058479442884036 0.43740350866606564 0.9969336020400068 0.011659600453826737 0.0915660847194396 0.07246537582179587 0.010757797025174213 0.0371340038892789 1.1692501232613987e-07 6.932092575636484 -0.5684444356223379 K(ub)GVAINMVTEEDKR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 119233260.0 25540000.0 76196100.0 17497160.0 True False 21237641.61384137 75785616.48555836 21155735.258272815 1.0 3.5684572639254832 0.9961433403455131 24.340120231628354 -6.646495462226872 2.02085530427296 2.671238787202699 1.0068860639023713 0.1800688520025595 1.0971880798975644 0.5171484958236007 4.04395459544541 0.4409171434934452 1.2152612840680286 2.2568595764167733e-07 6.646495462226872 -1.6643527233003275 K(ub)GVAINMVTEEDKR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 184498400.0 32151500.0 50764400.0 101582500.0 True False 41620750.55081432 47939316.51450602 83095527.32446924 1.0 1.1518128789142672 1.99649276442093 25.310799645771436 -6.937452773003847 0.6828546898245046 0.9899718357173988 2.2081600467394886 0.997810804798816 0.0205109089727776 0.088948211128931 0.06004821404098758 0.01959963830719131 0.07355294172329452 1.154907567334444e-07 6.937452773003847 1.2181882110220899 K(ub)GVNLPGAAVDLPAVSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGVNLPGAAVDLPAVSEK 18 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 13070200.0 3340900.0 5271700.0 4457600.0 True False 4379952.25332162 4485182.908925653 3996370.312318516 1.0 1.0240255257404303 0.912423259702841 22.06248371214798 -6.850377449194631 1.2333200657813532 1.0128247955053324 0.9079305633503891 0.9408455237777371 0.011664830001264052 0.1570430607909674 0.45949385058796693 0.007400339081277162 0.017128459242452446 1.4113104290125744e-07 6.850377449194631 -0.10489423215494331 K(ub)GVNLPGAAVDLPAVSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGVNLPGAAVDLPAVSEK 18 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 18831800.0 6626500.0 3796200.0 8409100.0 True False 6416145.384662711 5312042.456921472 6206504.4424074665 1.0 0.8279180315364253 0.9673260299312458 22.613275401789632 -9.997970894889383 5.238729598866292 1.0000005765632822 0.8976220307468565 0.4182930354937604 0.05691307702310104 3.8326760248111736e-07 7.335717202923069e-08 0.05510616026261309 0.018368616624118664 1.0046831188646758e-10 9.997970894889383 -0.10237854581642569 K(ub)GVNLPGAAVDLPAVSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGVNLPGAAVDLPAVSEK 18 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 82333600.0 9568600.0 0.0 72765000.0 True False 14516265.758362118 0.0 58382965.855967574 1.0 0.0 4.021899765946071 23.79116703870421 -6.840882903614959 1.2782278209609745 0.4680584665142364 4.156561320912903 0.925969951049562 0.46518212113933083 0.16777097667854032 0.5320802624868214 0.28531851389168505 0.6575044228119868 1.4425042334214195e-07 6.840882903614959 3.688502854398667 K(ub)GVNLPGAAVDLPAVSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGVNLPGAAVDLPAVSEK 18 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 13367300.0 3340900.0 5195300.0 4831100.0 True False 4576121.01442773 4965754.4674403425 3690093.6796276923 1.0 1.0851449189792326 0.8063802657301797 22.12569377367087 -6.824733485223346 1.3512368157193912 1.0456864925609481 0.7996524473414198 0.8949318394933299 0.037808559972162155 0.18740182582696663 0.6709996225735507 0.021980086594371895 0.050608975731508264 1.4971541372407696e-07 6.824733485223346 -0.24603404521952832 K(ub)GVNLPGAAVDLPAVSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGVNLPGAAVDLPAVSEK 18 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 15803600.0 6626500.0 5691900.0 3485200.0 True False 5510228.353724343 5661236.604946302 4213939.206255903 1.0 1.0274050804300867 0.764748561356394 22.39368067722391 -6.881134259880172 1.0734222778906155 1.017255121033935 0.7457222638539032 0.9745901979045158 0.01879221763004916 0.12663146707806452 0.2662382238728267 0.013471557986004551 0.03267445442656582 1.314818300118159e-07 6.881134259880172 -0.27153285718003173 K(ub)GVNLPGAAVDLPAVSEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGVNLPGAAVDLPAVSEK 18 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 85916600.0 9568600.0 9022000.0 67326000.0 True False 12386741.325304314 8519917.769024605 55073358.82309673 1.0 0.6878255987811459 4.446153946122202 23.56229336079666 -6.886739090540867 1.0414506194559399 0.7819945912628512 4.749518755528303 0.9787288345414541 0.24836011036724312 0.12183003415782238 0.23760727183900612 0.1824339316311491 0.44979825055069544 1.2979588066217012e-07 6.886739090540867 3.967524164265452 up K(ub)GYMGHLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGYMGHLTR 9 1 Q9UPN7 Q9UPN7 PPP6R1 Serine/threonine-protein phosphatase 6 regulatory subunit 1 1 4070530.0 748530.0 1031500.0 2290500.0 True False 981330.0787748301 877604.2207555079 2053501.0320274509 1.0 0.8943007452203833 2.092569132896857 19.90437895534115 -6.885396555895925 1.0492095365976926 0.9283329103299658 2.1868031442894007 0.9777853577873713 0.08073468215044226 0.12295863678421273 0.24429196184802712 0.0589552115579374 0.14474294672851895 1.3019773951501326e-07 6.885396555895925 1.258470233959435 up K(ub)GYMGHLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGYMGHLTR 9 1 Q9UPN7 Q9UPN7 PPP6R1 Serine/threonine-protein phosphatase 6 regulatory subunit 1 1 4254230.0 748530.0 1272100.0 2233600.0 True False 1025281.7692626499 1215894.4157278445 1706069.6824359708 1.0 1.1859124507814833 1.6640007982029388 19.967589016864043 -6.954853828176606 0.5027418570014024 0.9906487564832408 1.8799812511300826 0.999529192685347 0.006068696434054155 0.08159327213501565 0.028334432031093242 0.007080848140956636 0.03944210474747771 1.1095481964572826e-07 6.954853828176606 0.8893324946468418 K(ub)GYMGHLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGYMGHLTR 9 1 Q9UPN7 Q9UPN7 PPP6R1 Serine/threonine-protein phosphatase 6 regulatory subunit 1 1 7437240.0 932940.0 4376100.0 2128200.0 True False 775780.9462496933 4352525.080712161 2573196.7803149936 1.0 5.610507839556109 3.3169115492645562 19.565289817090555 -9.181682941037085 9.205652618270884 0.9998421282598304 4.4637096944154555 0.7525242053555817 0.9363567689807573 148130824.69048464 0.0 0.9066235410798301 0.32053982694045424 6.581381392088767e-10 9.181682941037085 3.463867566155625 K(ub)HCMDYLMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KHCMDYLMK 9 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 6050900.0 2376300.0 1915200.0 1759400.0 True False 3115352.312121931 1629459.6253911285 1577354.1653565145 1.0 0.5230418463590302 0.5063164635405701 21.570963894759547 K(ub)HCMDYLMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KHCMDYLMK 9 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 13999600.0 3858900.0 5772500.0 4368200.0 True False 5854233.4233789295 4742352.274251649 3504823.3553499286 1.0 0.8100722897916961 0.598681860096898 22.48104884018826 -6.969742198481628 0.26426849737578917 1.056338923477339 0.3461083507367988 0.9999803013273829 0.000727486432210102 0.07638641911240791 0.009328918077877892 0.004294120382913865 0.019820062186747426 1.0721555585652276e-07 6.969742198481628 -0.7102305727405402 K(ub)HCMDYLMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KHCMDYLMK 9 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 7268300.0 2376300.0 2271100.0 2620900.0 True False 3254882.3270928822 2170755.2924766177 2001897.3991298499 1.0 0.6669228175801492 0.6150444771740355 21.63417395628244 -13.999999999973253 0.2617549321200683 3.460755639829723 0.5963995960450547 0.9995659348745868 0.0035535229437208275 14.495500634892435 0.1619086415695776 18.887627594419666 0.022472915327691325 1.0000000000615864e-14 13.999999999973253 -2.8643560437846682 K(ub)HEETECPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KHEETECPLR 10 1 O14545;F8VNX8;F8VVF3;O14545-2;S4R2Z9 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 3756510.0 1321300.0 1730900.0 704310.0 True False 1732237.095487401 1472656.4669953545 631434.7574185785 1.0 0.8501471714419048 0.3645198218324214 20.72420497806882 -6.949703978269671 0.5620845728565358 1.0062834135367282 0.18509149198085598 0.9991778440628973 0.007777242988929217 0.08360483601910869 0.03645605474259552 0.008315926627606154 0.04038732500970394 1.1227834998651475e-07 6.949703978269671 -0.8211919215558723 down K(ub)HEETECPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KHEETECPLR 10 1 O14545;F8VNX8;F8VVF3;O14545-2;S4R2Z9 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 3638620.0 1321300.0 1503900.0 813420.0 True False 1809820.3167898955 1437452.7252677479 621306.9489107573 1.0 0.7942516237288012 0.3432975876924503 20.78741503959171 -6.958215210805652 0.45989679222177243 1.0131580585017195 0.10621545517247745 0.9996981705267225 0.004764721754765718 0.08034493640919046 0.023534359050318667 0.006123392021017338 0.03725375660984752 1.1009935866631386e-07 6.958215210805652 -0.906942603329242 down K(ub)HFPEFPATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KHFPEFPATR 10 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 27102000.0 5338900.0 13872000.0 7891100.0 True False 6999349.601981148 11802351.67263248 7074604.668776161 1.0 1.6862069111809839 1.0107517228134615 22.738789438583076 -10.452954442339804 5.113217674420248 0.9994440778366195 1.3484793169972342 0.26193533123443735 0.2757534259360285 0.0017502675695906746 0.0001872544037243569 0.26741149273980314 0.08899903552581737 3.524078368228445e-11 10.452954442339804 0.34903523916061474 K(ub)HFPEFPATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KHFPEFPATR 10 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 71995000.0 15034000.0 16250000.0 40711000.0 True False 14556753.899195557 22738709.74263054 30047567.796179213 1.0 1.5620728288802863 2.064166778133119 23.795185340101547 -6.9724606353507435 0.19045365384684518 0.6617191010016737 2.97824339956507 0.9999957549752282 0.0008955605974973078 0.07551207608539419 0.006079100558791556 0.01765767798312425 0.054665143525329 1.0654654335621533e-07 6.9724606353507435 2.316524298563396 K(ub)HFPEFPATR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KHFPEFPATR 10 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 59567000.0 10321000.0 23526000.0 25720000.0 True False 15657711.5661701 19327601.490523044 20636430.726523522 1.0 1.2343822664534243 1.3179723383786424 23.900370036904967 -13.593057238490543 0.14784502505963842 2.0507217397253667e-08 1.414044315133944 0.9995756741855631 0.0027724239161593407 10.352739729877905 0.11771646754427349 3.0265570426649293 0.08466061649680415 2.5523648877462374e-14 13.593057238490543 1.4140442946267264 K(ub)HFPEFPATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KHFPEFPATR 10 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 21632600.0 5338900.0 8156400.0 8137300.0 True False 7312835.608347521 7796023.278392091 6215437.332954077 1.0 1.0660739138581232 0.849935328213754 22.801999500105968 -6.824656807038122 1.351557941716834 1.035455998121574 0.844726705512745 0.8947693754851267 0.029335387846615293 0.18749917113229558 0.6716887159300099 0.01705017870217357 0.0392586953350928 1.497418495186759e-07 6.824656807038122 -0.1907292926088291 K(ub)HFPEFPATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KHFPEFPATR 10 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 52348100.0 15034000.0 28806000.0 8508100.0 True False 12501437.119126523 28650816.360456713 10287104.372990308 1.0 2.291801821457992 0.8228737444314778 23.575590615535823 -6.6745085419844115 1.9219676190047053 1.821349471228722 0.8287510539497508 0.2989946310706365 0.5481677900251868 0.45080115133494303 3.2147431428086435 0.22929623471535177 0.6089148943308255 2.115882068296356e-07 6.6745085419844115 -0.9925984172789711 K(ub)HLEINPDHPIVETLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KHLEINPDHPIVETLR 16 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 38412000.0 12005000.0 14403000.0 12004000.0 True False 15738671.256585369 12254128.54245429 10761941.230498783 1.0 0.7785999429479742 0.6837896957785287 23.907810410110738 -13.999999999999979 0.11577108533508358 2.059425430291496 0.5234702187578356 0.9997139178430882 0.0022410194856345524 11.981905058692346 0.10414538205769715 2.93826209114635 0.1422661595846903 1.000000000000049e-14 13.999999999999979 -1.5359552115336603 K(ub)HLEINPDHPIVETLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KHLEINPDHPIVETLR 16 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 58659000.0 14141000.0 14112000.0 30406000.0 True False 13692101.695392063 19746995.193107817 22441756.439552546 1.0 1.4422179759118694 1.6390293425227107 23.70684057704535 -11.300863651355868 0.1472010565350332 1.8985512963893164e-18 1.9044483375881915 0.9996463701370221 0.005025047427922454 3.8282981800300475 0.09073500049789728 1.4474494086969139 0.19251941532135086 5.001915476432141e-12 11.300863651355868 1.9044483375881915 K(ub)HLEINPDHPIVETLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KHLEINPDHPIVETLR 16 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 91694000.0 16632000.0 18115000.0 56947000.0 True False 25231959.96207164 14882236.71685901 45691400.48924323 1.0 0.5898169123298308 1.810854192774797 24.588748940194254 -6.816108775284385 1.3886597948410477 0.7780084156764888 1.8353431845102481 0.8751919829417536 0.17923869255903802 0.1985860387221459 0.7535019584101849 0.10145617546170221 0.23411344542868204 1.5271835053107288e-07 6.816108775284385 1.0573347688337593 K(ub)HLEINPDHPIVETLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KHLEINPDHPIVETLR 16 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 43389000.0 12005000.0 18775000.0 12609000.0 True False 16443572.922926433 17945458.419377625 9631013.890506424 1.0 1.0913357153880583 0.5857008045422046 23.97102047163363 -6.8601605027578705 1.1850159003905807 1.0495709075148871 0.5611507381116118 0.9538306132466376 0.04727439720433076 0.14663040620694076 0.391186331286918 0.031114503179647788 0.07263925523719518 1.3798742085110068e-07 6.8601605027578705 -0.4884201694032754 K(ub)HLEINPDHPIVETLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KHLEINPDHPIVETLR 16 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 43890200.0 14141000.0 20756000.0 8993200.0 True False 11758868.052518828 20644183.308256574 10873636.540141324 1.0 1.7556267504706333 0.9247179653327361 23.487245852479628 -6.6673536266987234 1.946701592371717 1.4834187925285882 0.9281140787488816 0.26729558650977203 0.3211735575432447 0.4672894292783613 3.4114468290046287 0.13293965469384858 0.3564184560063377 2.1510295336832532e-07 6.6673536266987234 -0.5553047137797066 K(ub)HLEINPDHPIVETLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KHLEINPDHPIVETLR 16 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 74176000.0 16632000.0 24397000.0 33147000.0 True False 21530451.86573389 23039285.503313404 27114586.11694125 1.0 1.0700790511499134 1.2593598260747425 24.359875262286703 -6.953784402774011 0.5156263535356188 0.9966714256083287 1.3411515633575544 0.9994657778973132 0.0025319906127643332 0.08200076855360397 0.029941701712449642 0.002888813183513384 0.015628438215291317 1.11228376234104e-07 6.953784402774011 0.3444801377492257 K(ub)HSQFIGYPITLYLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KHSQFIGYPITLYLEK 16 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 9538800.0 1295400.0 5894900.0 2348500.0 True False 1698281.9446714465 5015403.898140229 2105499.7484027357 1.0 2.953222174843601 1.23978221343575 20.69564456084926 -6.614473974236592 2.1365308013932225 2.300935008033697 1.2460143496671623 0.06478111957059651 0.8411229223692444 0.6003359870717108 5.199063713103085 0.3243180165375331 0.9335516854933683 2.42955103223264e-07 6.614473974236592 -1.054920658366535 K(ub)HSQFIGYPITLYLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KHSQFIGYPITLYLEK 16 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 18642400.0 5594200.0 8914700.0 4133500.0 True False 5416615.183110261 12474386.199546361 3050812.347658045 1.0 2.302985495156308 0.5632322482813419 22.368960169245412 -6.706254442130741 1.8085674527474342 1.8040883089114048 0.5677514869150899 0.44731732118175316 0.5494026412567111 0.3826407617976849 2.4373438155948177 0.2419619646390298 0.6175027021147086 1.9667336926729728e-07 6.706254442130741 -1.236336821996315 K(ub)HSQFIGYPITLYLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KHSQFIGYPITLYLEK 16 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 19380900.0 5594200.0 9288600.0 4498100.0 True False 4651825.165080317 9238560.46815725 5438631.9131354485 1.0 1.9860076723235447 1.1691393636118192 22.149365444679688 -10.120511983895154 4.268183922390383 0.9999202018332781 1.5775735168463212 0.3999670877420334 0.33348509101755963 47722619.64920759 37719231.58392119 39971.73429082797 0.11416081485632795 7.5768382509665e-11 10.120511983895154 0.5776533150130431 K(ub)HSQFIGYPITLYLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KHSQFIGYPITLYLEK 16 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 38665100.0 10167100.0 8322700.0 20175300.0 True False 13161511.373503074 7859534.4287587125 16503602.416059498 1.0 0.5971604784372735 1.2539291231617036 23.64982183154148 -6.740737527228753 1.6840169542924628 0.760516599336622 1.2543747498428535 0.6082381233968825 0.16925337508208893 0.3164845952417008 1.7625770042564781 0.0795012615266686 0.19492963370802974 1.8166132301459169e-07 6.740737527228753 0.4938581505062315 K(ub)HTGYVGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KHTGYVGLK 9 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 4540400.0 1360400.0 1883500.0 1296500.0 True False 1783497.5741323405 1602489.1418254958 1162350.6169061726 1.0 0.8985092915560011 0.6517253702863309 20.76627782281344 -6.956053558268092 0.48788423725069 1.0055056835600247 0.5343017120038559 0.9995946735803113 0.0029443765385784477 0.08114219954240327 0.026578497517993252 0.0035371107595698085 0.02035416381292714 1.1064873208142407e-07 6.956053558268092 -0.4712039715561688 K(ub)HTGYVGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KHTGYVGLK 9 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 5140200.0 1716100.0 1827200.0 1596900.0 True False 1661623.3448456458 2556810.488722124 1178623.9840268877 1.0 1.538742517462425 0.7093207902278084 20.664161959791528 -6.731393852065894 1.718264728001407 1.3237056770306814 0.7096950450263099 0.5657054604539584 0.22644974543449692 0.3336101369340499 1.9302809308743836 0.1044142821635181 0.25867752484513395 1.856120417020576e-07 6.731393852065894 -0.6140106320043716 K(ub)HTGYVGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KHTGYVGLK 9 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 4148100.0 1360400.0 1510200.0 1277500.0 True False 1863376.643427666 1443474.3704364346 975780.8109383754 1.0 0.7746551807052682 0.5236626821421538 20.82948788433633 -6.969732518801028 0.26449708251404164 1.0667076761576835 0.22411954766507114 0.9999802197542044 0.0008652764837923495 0.07638960038753456 0.009340269084198043 0.005091231899055266 0.023525401452933633 1.072179455343677e-07 6.969732518801028 -0.8425881284926123 K(ub)HTGYVGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KHTGYVGLK 9 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 4075180.0 1716100.0 1855300.0 503780.0 True False 1427013.186120326 1845305.1306517837 609118.068784459 1.0 1.2931240920545968 0.42684824128394433 20.444567235225804 -6.81542126554977 1.3915488820787112 1.1587643473938727 0.4097301158566593 0.873514515603968 0.1279486416416648 0.19951064833482135 0.7603194120716822 0.0722751653681085 0.1668213965225341 1.5296030272554724e-07 6.81542126554977 -0.7490342315372134 down K(ub)IAGVDYVYFVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIAGVDYVYFVQK 13 1 Q92503-3;Q92503;Q92503-2;K7EJ08;K7ELM0;K7ESI4 Q92503-3 SEC14L1 SEC14-like protein 1 1 6847200.0 2264700.0 2610600.0 1971900.0 True False 2192808.338134106 3653026.194099156 1455400.2342680297 1.0 1.6659122142920946 0.6637152043604742 21.064348288445927 -6.727589573137758 1.731944669093582 1.4018297834916835 0.6645711993981215 0.5479819335601807 0.2799933482170957 0.3408312495094462 2.0017667781437494 0.12816850540160546 0.3189220732802139 1.872450850628222e-07 6.727589573137758 -0.737258584093562 K(ub)IAGVDYVYFVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KIAGVDYVYFVQK 13 1 Q92503-3;Q92503;Q92503-2;K7EJ08;K7ELM0;K7ESI4 Q92503-3 SEC14L1 SEC14-like protein 1 1 6346170.0 2264700.0 3085500.0 995970.0 True False 1883198.393221086 3068877.799076205 1204222.7221550238 1.0 1.629609397567026 0.6394561117351427 20.844753563880204 -6.734918093843093 1.7054757555748206 1.3768045769380315 0.6395136942176436 0.581864047205967 0.26458535333932826 0.32707873092532586 1.8659394040452861 0.1228381687696149 0.3031115154308494 1.841119196252482e-07 6.734918093843093 -0.7372908827203879 K(ub)IALESEGRPEEQMESDNCSGGDDDWTHLSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KIALESEGRPEEQMESDNCSGGDDDWTHLSSK 32 2 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 76774800.0 15186000.0 23340600.0 38248200.0 True False 19908993.061433174 19858273.46094621 34290643.16664147 1.0 0.9974524276375777 1.7223695372654377 24.2469169198248 -6.9061087274674025 0.9218359187695245 0.974700226677516 1.8086525362558354 0.9893680501942316 0.03517440616082217 0.10704785622647965 0.15314555280391773 0.028254719169767534 0.07604418497225851 1.2413414935740248e-07 6.9061087274674025 0.8339523095783195 K(ub)IALESEGRPEEQMESDNCSGGDDDWTHLSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIALESEGRPEEQMESDNCSGGDDDWTHLSSK 32 2 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 58960500.0 20960600.0 21266900.0 16733000.0 True False 20295217.22625238 29758884.075418375 12350125.320760155 1.0 1.466300347695934 0.6085239287207507 24.274636445959874 -6.759059826410936 1.6158481244178742 1.2711646753191301 0.6055163220618106 0.6871989036429151 0.19610229809198892 0.28449012022945075 1.4637336793210864 0.09576234740107795 0.23036094599998372 1.7415669466115688e-07 6.759059826410936 -0.6656483532573195 K(ub)IALESEGRPEEQMESDNCSGGDDDWTHLSSK ddPTM_RPMI8226_Bortezomib_8h_R1 2 KIALESEGRPEEQMESDNCSGGDDDWTHLSSK 32 2 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 510255000.0 65253000.0 250347000.0 194655000.0 True False 98993571.633301 205670621.87996116 156181353.9296825 1.0 2.077615934919702 1.577691877895067 26.560831507849535 -10.455613672745848 5.48615196526255 0.9991463839757779 1.8276539064073842 0.7851542436598951 0.20409314164207734 0.002132835727873074 0.00021163928957529225 0.19779293033367115 0.06587077822124139 3.502565997305196e-11 10.455613672745848 0.8285075224316063 K(ub)IALESEGRPEEQMESDNCSGGDDDWTHLSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 KIALESEGRPEEQMESDNCSGGDDDWTHLSSK 32 2 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 71100200.0 19736200.0 23204100.0 28159900.0 True False 27033206.490750577 22178866.13630254 21509111.591345247 1.0 0.8204304636925348 0.7956552101469945 24.688229308675428 -13.999999999999998 0.2790751480434622 2.4560443344352128 0.788128552537371 0.9996031290796107 0.0018139138513956477 15.348426554092953 0.16733310007754665 12.748018312521282 0.009843633698011304 1.0000000000000041e-14 13.999999999999998 -1.6679157818978418 K(ub)IALESEGRPEEQMESDNCSGGDDDWTHLSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 KIALESEGRPEEQMESDNCSGGDDDWTHLSSK 32 2 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 64316600.0 24457100.0 16285200.0 23574300.0 True False 20337162.283237252 16197468.395240875 28503577.1347522 1.0 0.7964468282082556 1.4015513441738157 24.277615053067215 -6.815962709454562 1.3891323760938836 0.8898173291416696 1.413664573945626 0.8748733226306851 0.08892922520152795 0.19877816610566523 0.754755516523127 0.05031899142683857 0.11612704473169196 1.5276972278005144e-07 6.815962709454562 0.5238472448039564 K(ub)IALESEGRPEEQMESDNCSGGDDDWTHLSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 KIALESEGRPEEQMESDNCSGGDDDWTHLSSK 32 2 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 469158000.0 65253000.0 267061000.0 136844000.0 True False 84471294.82892828 252198820.58451346 111939796.13801266 1.0 2.98561565908594 1.3251814875658499 26.331957829941985 -6.602255564957373 2.182079821388666 2.3334447066677337 1.3306847835384863 0.026989051108250117 0.8577607431650361 0.63446281028567 5.712593525364956 0.32589010642846605 0.9538021538953495 2.498874441143466e-07 6.602255564957373 -1.0027599231292474 K(ub)IATEK(ub)DFLEAVNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIATEKDFLEAVNK 14 2 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 2 19692900.0 1733500.0 9446200.0 8513200.0 True False 1678470.991369928 13218116.921282232 6283337.529474407 1.0 7.875094052411308 3.7434889025672686 20.678716172806826 -9.736917362025352 8.310100903834003 1.0005202564515305 5.8092912790810525 0.643697679912667 1.6867207660404238 9.997409280850092e-09 2.7322117461925777e-17 1.6331603957062404 0.5443867823531924 1.8326631101074378e-10 9.736917362025352 4.8087710226295215 K(ub)IATEK(ub)DFLEAVNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KIATEKDFLEAVNK 14 2 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 2 13934200.0 2820200.0 0.0 11114000.0 True False 4278449.584237277 0.0 8917313.02856076 1.0 0.0 2.084239361242925 22.02865665979111 -6.7762280438161255 1.550452392781929 0.4310020797255979 2.0988703574344263 0.7538538184125212 0.4222665971310952 0.2564807833574336 1.2175019704646999 0.21456426992556113 0.5079252695214455 1.674063610650377e-07 6.7762280438161255 1.6678682777088283 K(ub)IATEK(ub)DFLEAVNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KIATEKDFLEAVNK 14 2 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 2 15777900.0 1733500.0 9956100.0 4088300.0 True False 1441482.0570710273 9902464.513168868 4943144.627836567 1.0 6.8696411894920555 3.4292099603935617 20.459121448241103 -9.367067071187524 9.825300146409106 1.0000826756592343 5.1494255749427955 0.6598056493252054 1.4045501685490958 0.0 0.0 1.3599498525593512 0.45331661751978364 4.2947009551981433e-10 9.367067071187524 4.149342899283561 K(ub)IATEKDFLEAVNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIATEKDFLEAVNK 14 2 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 74265000.0 0.0 74265000.0 0.0 True False 0.0 70132087.46581829 0.0 0.0 K(ub)IDQKAVDSQILPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KIDQKAVDSQILPK 14 2 Q02878 Q02878 RPL6 60S ribosomal protein L6 1 9283100.0 2428200.0 4000500.0 2854400.0 True False 3183393.714722252 3403640.993826866 2559054.069338202 1.0 1.069186314619532 0.8038760827802529 21.602134166496178 -6.837425346562117 1.2941813988430597 1.0368280457691728 0.7955791350251293 0.9199532843912805 0.031791992384829895 0.17182907089345842 0.560140227716817 0.019269549953123393 0.04437025192247456 1.454034306652745e-07 6.837425346562117 -0.24124891074404342 K(ub)IEEIKDFLLTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIEEIKDFLLTAR 13 2 P63173;J3KT73;J3QL01;J3KSP2 P63173 RPL38 60S ribosomal protein L38 1 18355600.0 6416200.0 5861900.0 6077500.0 True False 6212521.243050321 8202587.239404658 4485620.428908131 1.0 1.320331459402338 0.7220289884603616 22.566747449148547 -6.761264287556673 1.6076881428425172 1.1857724114899206 0.7197033087341892 0.6961273359998372 0.13475767910263586 0.280793101176953 1.43066776698638 0.06612608213755411 0.15871508846939605 1.7327492216858865e-07 6.761264287556673 -0.46606910275573143 K(ub)IEEIKDFLLTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KIEEIKDFLLTAR 13 2 P63173;J3KT73;J3QL01;J3KSP2 P63173 RPL38 60S ribosomal protein L38 1 16103900.0 6416200.0 6678000.0 3009700.0 True False 5335354.585854702 6642024.288520787 3639014.3547194903 1.0 1.2449077529224353 0.6820567023544013 22.347152724582823 -6.7884650020483015 1.502690504969496 1.1371524396487307 0.6763399082810587 0.7962443485094102 0.10401309746566333 0.23764658544987102 1.0601816967265298 0.05449017536494253 0.1277063739156394 1.6275524679132647e-07 6.7884650020483015 -0.460812531367672 K(ub)IENLCAMGFDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KIENLCAMGFDR 12 1 P61086;P61086-2;D6RDM7 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 1 9329000.0 2947600.0 3708500.0 2672900.0 True False 3864332.1445990046 3155206.2556197755 2396333.948267263 1.0 0.8164945810958975 0.6201159368809708 21.881787670426437 -6.9702629408233685 0.2518275795893217 1.0609368670274362 0.36990857381645154 0.9999843599301417 0.0006134210326363442 0.07621746974257435 0.008724381213185915 0.0043262884316277615 0.01876533989558377 1.0708707570597887e-07 6.9702629408233685 -0.6910282932109846 K(ub)IENLCAMGFDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIENLCAMGFDR 12 1 P61086;P61086-2;D6RDM7 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 1 7054600.0 2607900.0 2229200.0 2217500.0 True False 2525113.641992289 3119331.185124425 1636670.226425964 1.0 1.2353230893257163 0.6481570568581015 21.267916886713113 -6.797945613250455 1.4644250094557636 1.1301767415321746 0.64046892535598 0.8260590031628492 0.10062784299703338 0.22369777086266757 0.9473244497139657 0.054065112549163546 0.12588839814397007 1.5924081320246404e-07 6.797945613250455 -0.48970781617619463 K(ub)IENLCAMGFDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KIENLCAMGFDR 12 1 P61086;P61086-2;D6RDM7 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 1 34450800.0 11721600.0 15231000.0 7498200.0 True False 17782524.163745735 12512909.04965385 6016177.483422187 1.0 0.703663267061076 0.33831965743579406 24.08395678815708 -7.051780810857707 0.3083414899014626 1.0605515413980906 4.707954640272559e-14 0.9999590985840414 0.0017307135930976875 0.07297621118497996 0.011917209862334525 0.006213860721729424 0.03135551616177969 8.876038741513215e-08 7.051780810857707 -1.0605515413980435 down K(ub)IENLCAMGFDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KIENLCAMGFDR 12 1 P61086;P61086-2;D6RDM7 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 1 10887900.0 2947600.0 3819000.0 4121300.0 True False 4037407.375894875 3650263.9522558274 3147933.8208378227 1.0 0.9041108841405338 0.7796918982296396 21.94499773194933 -6.9675547257745 0.31110113450406407 1.018920233902048 0.6609213202517982 0.9999565345741666 0.0005945889435645045 0.07710439942109032 0.011856138483645914 0.001958841284104178 0.011034308534702216 1.0775694598001847e-07 6.9675547257745 -0.35799891365024983 K(ub)IENLCAMGFDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KIENLCAMGFDR 12 1 P61086;P61086-2;D6RDM7 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 1 5272100.0 2607900.0 1241400.0 1422800.0 True False 2168584.3995590024 1234712.3318013924 1720300.9017160833 1.0 0.569363282357136 0.7932828909337903 21.04832216214739 -10.07749820007492 4.92732099877021 1.0000090758662976 0.6813230866432811 0.7297714718701789 0.09141479741030374 126981663.63020259 5.359721583723377 13075.388046781825 0.03129371664347497 8.365690628929244e-11 10.07749820007492 -0.3186859892230165 K(ub)IENLCAMGFDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIENLCAMGFDR 12 1 P61086;P61086-2;D6RDM7 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 1 27065200.0 11721600.0 10881000.0 4462600.0 True False 15173842.26727913 10275462.784832278 3650452.5901427614 1.0 0.6771826544546522 0.24057536158884402 23.85508311024953 -7.272893994863908 0.38848331912195544 1.0345699004239515 2.900302022764053e-23 0.9996012176201219 0.006214352268541052 0.09870105204856983 0.028950517890091745 0.010985297030288487 0.04952731489266673 5.334650908756442e-08 7.272893994863908 -1.0345699004239515 down K(ub)IENVPTGPNNKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIENVPTGPNNKPK 14 2 C9JQD4;O43447;O43447-2;H0YEL5 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 1 4544900.0 1473300.0 1650700.0 1420900.0 True False 1426530.8979436485 2309833.11828678 1048723.6639137082 1.0 1.6191959961164641 0.7351566414898189 20.444079564633096 -6.718421283132104 1.7650035066637517 1.377341381395274 0.7366542304025082 0.5050787122910443 0.2606110472560839 0.35838065120529533 2.1810290301394244 0.11727957958994653 0.29496286582094033 1.9123999200513504e-07 6.718421283132104 -0.6406871509927657 K(ub)IENVPTGPNNKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIENVPTGPNNKPK 14 2 C9JQD4;O43447;O43447-2;H0YEL5 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 1 3468790.0 1551900.0 1487600.0 429290.0 True False 2008965.1425223916 1404813.752294505 351163.6248873717 1.0 0.6992723380609115 0.1747982667566158 20.938021101465882 -7.2718013327436415 0.4906110077495251 1.012480479134356 1.236684891691065e-28 0.998827145438087 0.011677873476130503 0.09687067815464771 0.04335743365025302 0.013263561143637494 0.05357076805429605 5.348089508743246e-08 7.2718013327436415 -1.012480479134356 down K(ub)IGDTSVSYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KIGDTSVSYK 10 1 P20700 P20700 LMNB1 Lamin-B1 1 2988240.0 856490.0 1197000.0 934750.0 True False 1122866.6842609593 1018412.2658694548 838031.0367551435 1.0 0.9069752270188215 0.7463317315418554 20.098755218903428 -6.962811259812614 0.3938148869769775 1.0094563162658992 0.6380431155504237 0.9998606738463812 0.001236759805444371 0.07871175602189126 0.01752949003993728 0.002070313771624798 0.013491686123093323 1.0894034346823649e-07 6.962811259812614 -0.37141320071547546 K(ub)IGDTSVSYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIGDTSVSYK 10 1 P20700 P20700 LMNB1 Lamin-B1 1 4428000.0 1050700.0 1730000.0 1647300.0 True False 1017346.103624103 2420798.0218308154 1215822.7120592957 1.0 2.3795225766405164 1.1950925134800805 19.956379140394922 -6.609105790954211 2.1571975131350145 1.9222389272054785 1.1993141848811462 0.047511120017369124 0.5948986984359961 0.6151731526121623 5.423522394514908 0.22784573785122772 0.6604808811115692 2.4597683496135364e-07 6.609105790954211 -0.7229247423243323 K(ub)IGDTSVSYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KIGDTSVSYK 10 1 P20700 P20700 LMNB1 Lamin-B1 1 3138590.0 856490.0 1238900.0 1043200.0 True False 1173157.498771951 1184161.3015055624 796817.6453784051 1.0 1.0093796465906155 0.6792077331581696 20.16196528042632 -6.9003630969238685 0.9589859949503275 1.0135909091961586 0.6442959566620432 0.9867456211210061 0.017669966000303655 0.1111379536863713 0.1759233959911405 0.013810102686342323 0.03599676989674549 1.2578733125163255e-07 6.9003630969238685 -0.3692949525341154 K(ub)IGDTSVSYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIGDTSVSYK 10 1 P20700 P20700 LMNB1 Lamin-B1 1 5720900.0 2591100.0 1389000.0 1740800.0 True False 3354230.0282168784 1311700.9289708692 1423992.2621163689 1.0 0.39105872821375176 0.4245362572445184 21.67755019954672 -9.96532923197366 5.3357082486052265 1.0000016398434 0.407797492727128 0.9976089536944087 0.013667144003911768 37546650.68091047 10.608088294927837 823.6841626258805 0.004678626916009157 1.0831055170661028e-10 9.96532923197366 -0.592204147116272 K(ub)IGYNPDTVAFVPISGWNGDNMLEPSANMPWFK ddPTM_RPMI8226_Bortezomib_8h_R1 2 KIGYNPDTVAFVPISGWNGDNMLEPSANMPWFK 33 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 596314200.0 139840000.0 112415200.0 344059000.0 True False 212147503.67340657 92353829.25603348 276055587.8435829 1.0 0.435328380758177 1.3012436303212906 27.660492461723845 -6.73075395558047 1.7206769317377475 0.6604622957493925 1.300779563976408 0.5626561963861654 0.23736076821034288 0.33483462377007406 1.9425360491257426 0.10930603001585125 0.27098399048125066 1.8588572705090146e-07 6.73075395558047 0.6403172682270154 K(ub)IGYNPDTVAFVPISGWNGDNMLEPSANMPWFK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 KIGYNPDTVAFVPISGWNGDNMLEPSANMPWFK 33 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 316683000.0 139840000.0 42662000.0 134181000.0 True False 181025636.65850332 40287822.197088055 109761434.81332533 1.0 0.2225531308203004 0.6063308868256341 27.431618783816294 -10.706975340671153 6.645784575320088 1.006609843106631 0.4144420088363496 0.7563341155058371 0.15667661280723502 0.01536003463741785 0.0006772507885325796 0.1518583169717253 0.05056715934521742 1.9634717599961265e-11 10.706975340671153 -0.5921678342702814 K(ub)ILATPPQEDAPSVDIANIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KILATPPQEDAPSVDIANIR 20 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 27525500.0 8157900.0 13084000.0 6283600.0 True False 10695085.901215976 11131918.201032544 5633433.348547341 1.0 1.0408442067554504 0.5267310053028045 23.350444734256392 -6.887681922451039 1.0360310060468274 1.0291786136429764 0.48447500279729616 0.9793714020943012 0.033511645819247746 0.12104272023999736 0.2330121545903218 0.024718576104950575 0.06112947373081599 1.2951440584850876e-07 6.887681922451039 -0.5447036108456802 K(ub)ILATPPQEDAPSVDIANIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KILATPPQEDAPSVDIANIR 20 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 45340000.0 16894000.0 17709000.0 10737000.0 True False 16357709.21730805 24780296.05121501 7924657.596904422 1.0 1.5149001441470205 0.4844601093971864 23.963467387293598 -6.770842940489995 1.5710067918801718 1.2950296772325602 0.4784550567793462 0.7337702027046993 0.21705783001339576 0.26511367914135875 1.2913987604969994 0.10889081901327397 0.25902869948024543 1.6949506564709346e-07 6.770842940489995 -0.816574620453214 down K(ub)ILATPPQEDAPSVDIANIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KILATPPQEDAPSVDIANIR 20 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 69864000.0 26626000.0 12725000.0 30513000.0 True False 40393588.621339515 10454124.329121212 24482092.17567703 1.0 0.25880652563754647 0.6060885653210667 25.267622986935496 -10.613501159410415 6.568902207993925 1.00164109196411 0.4324475454825515 0.7807554039546362 0.14177729900960057 0.0034152303338095547 0.00020094355335270185 0.13758721060487913 0.0457584264945377 2.4349992993690464e-11 10.613501159410415 -0.5691935464815586 K(ub)ILATPPQEDAPSVDIANIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KILATPPQEDAPSVDIANIR 20 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 29268900.0 8157900.0 15667000.0 5444000.0 True False 11174096.088958064 14974780.136159219 4158239.322699425 1.0 1.340133467346579 0.37213205342027467 23.413654795779284 -6.811737186659964 1.4071095196519787 1.184986729188885 0.3544952224038587 0.8643648810136872 0.14766903372256712 0.20442398290666422 0.7973766836212609 0.08250986833281439 0.19072624854260095 1.5426336954478732e-07 6.811737186659964 -0.8304915067850263 down K(ub)ILATPPQEDAPSVDIANIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KILATPPQEDAPSVDIANIR 20 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 38064400.0 16894000.0 17164000.0 4006400.0 True False 14048109.531097714 17071534.125212763 4844119.716499374 1.0 1.2152193209643063 0.3448236010529494 23.743872662727874 -6.841271615293251 1.276423865157697 1.1144796406523474 0.31545727561312165 0.9266304654794508 0.10026447334121523 0.16731502830745323 0.5289681181084889 0.06158028832402573 0.14192523151990247 1.4412137095796254e-07 6.841271615293251 -0.7990223650392257 down K(ub)ILATPPQEDAPSVDIANIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KILATPPQEDAPSVDIANIR 20 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 53210000.0 26626000.0 14841000.0 11743000.0 True False 34467881.87692581 14015085.303712519 9605894.493355092 1.0 0.40661289700817915 0.27869117480600586 25.038749309027946 -13.999999999999881 0.21564637950081933 4.5139319339530655 0.20734426597693095 0.9994939214997833 0.007069349655041452 12.884851486316116 0.1471461200293906 19.23726193473301 0.0728847207337641 1.000000000000274e-14 13.999999999999881 -4.306587667976134 K(ub)ILETSFGYQLPMVDSFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KILETSFGYQLPMVDSFK 18 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 11198300.0 3268400.0 4624100.0 3305800.0 True False 3164646.431031709 6470527.244362933 2439911.8081257944 1.0 2.0446288030519324 0.7709903337701952 21.593612893404003 -6.688833322881014 1.871663246192136 1.6556708790436743 0.7755818111804484 0.36453652216218235 0.44191458176838044 0.4191441194232927 2.8461674385054634 0.18899588396851796 0.49268344471608866 2.0472301888627398e-07 6.688833322881014 -0.8800890678632258 K(ub)ILETSFGYQLPMVDSFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KILETSFGYQLPMVDSFK 18 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 37958000.0 13645000.0 10622000.0 13691000.0 True False 20700462.58312094 8726421.109935205 10984967.849021515 1.0 0.42155681666025613 0.5306629165851882 24.303159671497387 -9.965950678996451 5.917278027823393 1.000000398550072 0.47610986662296106 0.9684952251822193 0.04454237877403076 2.3424304853668222e-07 4.0890538267008036e-08 0.04312800589338409 0.01437599093261752 1.0815567721919161e-10 9.965950678996451 -0.523890531927111 K(ub)ILETSFGYQLPMVDSFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KILETSFGYQLPMVDSFK 18 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 11910800.0 3268400.0 6756700.0 1885700.0 True False 2717819.4146702867 6720300.316000054 2279991.151508304 1.0 2.4726809587587444 0.8389045788698591 21.37401816883828 -6.6692184149652665 1.9399774029961616 1.9406296428142762 0.8455088531263981 0.27564954611879244 0.6256744028024356 0.4629214883341376 3.3580188914011897 0.2597026793133536 0.6946104346822659 2.1418131715820806e-07 6.6692184149652665 -1.095120789687878 K(ub)ILETSFGYQLPMVDSFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KILETSFGYQLPMVDSFK 18 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 23527200.0 13645000.0 0.0 9882200.0 True False 17663721.483161308 0.0 8083740.999934743 1.0 0.0 0.45764653884748535 24.074285993589836 -10.526951745184236 5.485980485322337 1.0019589367880561 0.22882326942374448 0.7910593799343051 0.1868334171211941 0.0044850275414962445 0.000386737147590254 0.18124845851903745 0.060300226085450055 2.971996234330122e-11 10.526951745184236 -0.7731356673643117 K(ub)INELTGIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KINELTGIK 9 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 16315000.0 3935800.0 6142100.0 6237100.0 True False 3810860.1833479973 8594672.56062837 4603416.401010766 1.0 2.2553103885006864 1.2079730505794823 21.861685247405834 -6.601670969287142 2.1847369749416456 1.8433255995453444 1.2114507973658666 0.025258661429080953 0.5423580850536066 0.6359908267043605 5.7396693330371145 0.2058981404560388 0.6029964427522606 2.5022403941539434e-07 6.601670969287142 -0.6318748021794778 K(ub)INELTGIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KINELTGIK 9 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 105595000.0 14927000.0 41613000.0 49055000.0 True False 22645350.30987516 34186835.02614703 39359257.74842968 1.0 1.5096624498336364 1.738072372908532 24.432711521392037 -10.927352956790745 0.15547877768491306 1.1024965363077001e-21 2.02820995440389 0.9996222092320737 0.005996708716477688 3.063908922775009 0.08902082465200115 1.3093832995519539 0.20337392069437807 1.1820804730153654e-11 10.927352956790745 2.02820995440389 K(ub)INELTGIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KINELTGIK 9 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 13823200.0 3935800.0 7558300.0 2329100.0 True False 3272792.085503399 7517581.93769492 2816104.041458341 1.0 2.2969934359697084 0.860459194438924 21.64209052284011 -6.668922833977318 1.9414733869168386 1.828659079708849 0.866335739792969 0.274113885808535 0.5510772079407565 0.46362785650621346 3.3681807990230808 0.22860989879085492 0.6115847548845967 2.143271386607875e-07 6.668922833977318 -0.9623233399158799 K(ub)INELTGIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KINELTGIK 9 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 104745000.0 14927000.0 41363000.0 48455000.0 True False 19323295.755159333 39061112.68900074 39636687.19028538 1.0 2.0214518881216934 2.051238447753011 24.203837843484486 -10.967204752047962 0.6123979537292649 8.43533973263201e-20 2.047417120966513 0.9999233301664175 0.004279022124809009 2.8294265756721857 0.30341979069938474 4.017076392858917 0.0050985398759971915 1.078438162964502e-11 10.967204752047962 2.047417120966513 K(ub)INFDALLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KINFDALLK 9 1 F8VQW0;F8VX73;F8VPI1;F8W201;F8W086;F8VR05;F8VQQ5;F8VSI7;F8VVJ4;P55061;P55061-2;F8W1G3 F8VQW0 TMBIM6 Bax inhibitor 1 1 63454500.0 8818500.0 10398000.0 44238000.0 True False 11561138.898475489 8846658.93108655 39660676.12086017 1.0 0.7652065258253333 3.4305163590837946 23.462780190272376 -6.885427227230445 1.0490316675263567 0.8407013777110182 3.640246873185211 0.9778072964785186 0.179499011865685 0.12293275134543172 0.24413732462180035 0.13109392979689916 0.3218839343384503 1.3018854483817377e-07 6.885427227230445 2.799545495474193 up K(ub)INFDALLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KINFDALLK 9 1 F8VQW0;F8VX73;F8VPI1;F8W201;F8W086;F8VR05;F8VQQ5;F8VSI7;F8VVJ4;P55061;P55061-2;F8W1G3 F8VQW0 TMBIM6 Bax inhibitor 1 1 143729000.0 12220000.0 20329000.0 111180000.0 True False 11832082.788889803 28446475.714334525 82058622.67149435 1.0 2.404181598614697 6.935264410805721 23.49620071631008 -6.949801318577749 0.5610198970314685 0.9410528524435825 8.615320565284154 0.999185604559563 0.07227638806364817 0.08356560890216146 0.03629319455322734 0.0773810768574531 0.3767398603536409 1.122531873723912e-07 6.949801318577749 7.674267712840572 K(ub)INFDALLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KINFDALLK 9 1 F8VQW0;F8VX73;F8VPI1;F8W201;F8W086;F8VR05;F8VQQ5;F8VSI7;F8VVJ4;P55061;P55061-2;F8W1G3 F8VQW0 TMBIM6 Bax inhibitor 1 1 180439600.0 4987600.0 76346000.0 99106000.0 True False 7566553.842401907 62721459.805979446 79517655.66029713 1.0 8.289303309321237 10.509097974654106 22.85120494925933 -9.028070350492563 0.4765158394148718 1.8109216804669476e-16 10.618588426343988 0.9970098051026055 0.22211038829930954 0.48459044461194273 0.18478433177337472 1.5651985746823855 0.4691160758823458 9.374101454359607e-10 9.028070350492563 10.618588426343988 K(ub)INFDALLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KINFDALLK 9 1 F8VQW0;F8VX73;F8VPI1;F8W201;F8W086;F8VR05;F8VQQ5;F8VSI7;F8VVJ4;P55061;P55061-2;F8W1G3 F8VQW0 TMBIM6 Bax inhibitor 1 1 81296900.0 8818500.0 7295400.0 65183000.0 True False 12078937.761001827 6973065.105338352 49788117.88602435 1.0 0.5772912522036214 4.121895391064166 23.525990251795267 -6.877132985184012 1.0957191257832144 0.7467717265321527 4.359633634818414 0.971295826521439 0.267816675809911 0.13019734871495503 0.28792165910132306 0.18875003942708377 0.45328087822264906 1.3269880588928184e-07 6.877132985184012 3.612861908286262 up K(ub)INFDALLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KINFDALLK 9 1 F8VQW0;F8VX73;F8VPI1;F8W201;F8W086;F8VR05;F8VQQ5;F8VSI7;F8VVJ4;P55061;P55061-2;F8W1G3 F8VQW0 TMBIM6 Bax inhibitor 1 1 108895000.0 12220000.0 19154000.0 77521000.0 True False 10161471.437789394 19050813.600228693 93730282.68339369 1.0 1.8748085566998511 9.224085631419587 23.276605991744358 -6.929197374053342 0.7533526490392197 0.8848487085284936 10.702465691296648 0.9963781221394246 0.22195195214577101 0.09305669661925767 0.0797379572021624 0.20125197096801592 0.6679416824690882 1.1770709078778395e-07 6.929197374053342 9.817616982768154 K(ub)INFDALLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KINFDALLK 9 1 F8VQW0;F8VX73;F8VPI1;F8W201;F8W086;F8VR05;F8VQQ5;F8VSI7;F8VVJ4;P55061;P55061-2;F8W1G3 F8VQW0 TMBIM6 Bax inhibitor 1 1 161053600.0 4987600.0 48406000.0 107660000.0 True False 6456546.520294273 45712163.54770626 88066984.68488543 1.0 7.079971220531501 13.63995200964982 22.62233127135178 -7.350474919742396 0.3271945450620463 2.8288003982660716e-16 18.423890318600243 0.9996329833953508 0.09888194868547777 0.1287991298575964 0.031068676595530524 0.29486694730936946 1.0935758798013062 4.461953913652581e-08 7.350474919742396 18.423890318600243 K(ub)IQASTMAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KIQASTMAFK 10 1 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 1 1574990.0 0.0 767570.0 807420.0 True False 0.0 733656.2193854424 616724.025336878 0.0 K(ub)IQASTMAFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIQASTMAFK 10 1 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 1 6031600.0 2003600.0 2241400.0 1786600.0 True False 2593699.6968605346 2116664.11965105 1461457.1320640536 1.0 0.8160791020691801 0.563464279936891 21.306580020798872 -6.966680079322614 0.3279422095110052 1.0315244001178836 0.33977466012213237 0.9999437036319919 0.0013426578579333356 0.07739540330135213 0.012874211973836069 0.0037135611461247683 0.022070556265329694 1.079741815302319e-07 6.966680079322614 -0.6917497399957513 K(ub)IQEAASQGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KIQEAASQGLK 11 1 G3XAJ6;Q14699;C9JHG2 G3XAJ6 RFTN1 Raftlin 1 4074400.0 1300500.0 1681800.0 1092100.0 True False 1704968.094059916 1430881.9956050538 979099.9681629246 1.0 0.839242681778167 0.5742629270155228 20.70131331093595 -6.963642988399274 0.3806252109420175 1.0180740880453714 0.3860518686821927 0.9998823789774977 0.0019037126453303093 0.07842452889003802 0.016502603823697115 0.003446265937642674 0.022383855239159832 1.0873190865404722e-07 6.963642988399274 -0.6320222193631786 K(ub)IQEAASQGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIQEAASQGLK 11 1 G3XAJ6;Q14699;C9JHG2 G3XAJ6 RFTN1 Raftlin 1 2904370.0 899240.0 1143800.0 861330.0 True False 870694.1184190896 1600525.3048382038 635721.8336538777 1.0 1.8382176598875632 0.7301322246303344 19.73180645233584 -6.704407132863743 1.8154356454851948 1.5182348189259611 0.7331656753921423 0.4384541276310413 0.35354391146948067 0.38638690246562896 2.478779615907803 0.15519631294054287 0.3969252170929751 1.9751171824189512e-07 6.704407132863743 -0.7850691435338188 K(ub)IQEQDIINFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIQEQDIINFR 11 1 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 26033600.0 6807100.0 7305500.0 11921000.0 True False 6591012.336518157 10222624.247679213 8798532.477665808 1.0 1.5509945552733606 1.3349288437705793 22.652068640127702 -10.124959689587746 4.53892573063155 0.9999536114493898 1.4429616995335175 0.8485769921404835 0.08820845739130462 10299937.827290807 22976025.105326187 2900.3957782009156 0.030196103101875024 7.499638163592712e-11 10.124959689587746 0.4430080880841277 K(ub)IQEQDIINFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KIQEQDIINFR 11 1 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 13942000.0 3001800.0 6457600.0 4482600.0 True False 4111646.580594804 6172281.879572462 3423902.2020448977 1.0 1.5011703361623945 0.8327326133049073 21.97128483134235 -6.7060492955469995 1.8090359143235946 1.3093485477814513 0.8344650093327262 0.4463439792411118 0.21132692206943468 0.3831217147154857 2.441479211443615 0.0930448132620405 0.23753922605527475 1.9676629331370988e-07 6.7060492955469995 -0.4748835384487251 K(ub)IQEQDIINFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KIQEQDIINFR 11 1 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 25965510.0 6807100.0 12397700.0 6760710.0 True False 5660405.255660906 12330911.129349224 8174343.203008818 1.0 2.178450229692869 1.4441268484855836 22.432473915561978 -10.07857466229401 4.724840736068396 0.999969196533236 1.8112885390872964 0.6194066699252057 0.2997862650902135 208234476.45442754 1.782054887816748 81421.92425807103 0.10262481237771881 8.344980721361707e-11 10.07857466229401 0.8113193425540604 K(ub)IQEQDIINFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIQEQDIINFR 11 1 Q9NS56-2;Q9NS56 Q9NS56-2 TOPORS E3 ubiquitin-protein ligase Topors 1 27201500.0 5838600.0 8112900.0 13250000.0 True False 7558182.796012136 7661409.983187746 10838635.956480885 1.0 1.013657672745104 1.434026703111704 22.84960798018338 -6.913815818696735 0.8693564210639059 0.9885019191359475 1.4930291397611342 0.9922833169135475 0.01769719859385738 0.10194859577943814 0.12548427971529627 0.014768002788018871 0.04192856927511451 1.219506673667324e-07 6.913815818696735 0.5045272206251866 K(ub)IQSQFTDAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KIQSQFTDAQK 11 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 2319880.0 514120.0 756060.0 1049700.0 True False 674016.2987451623 643258.7950987972 941087.113433405 1.0 0.9543668250995898 1.396237917666764 19.36242395283877 -6.88142410577262 1.0718720505731025 0.9711512550326196 1.4284149919048474 0.9748141237013157 0.031489479650919215 0.12637394653977085 0.26475220052938453 0.022601552462997457 0.054857351209380276 1.3139410899360023e-07 6.88142410577262 0.4572637368722279 K(ub)IQSQFTDAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIQSQFTDAQK 11 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 2461090.0 792000.0 584990.0 1084100.0 True False 766858.3935188821 818579.5576825502 800141.6876971297 1.0 1.0674455213645575 1.0434021384646004 19.5486006716836 -9.989065659872065 5.0979303499355195 0.9999996110681907 1.0554238299150498 0.8763143248722576 0.009815669967514326 4.3412231855543216e-08 8.61191211329642e-09 0.009504048281785717 0.0031679938594357682 1.0254968722810573e-10 9.989065659872065 0.05542421884685911 K(ub)IQSQFTDAQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KIQSQFTDAQK 11 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 6737600.0 1089300.0 1719700.0 3928600.0 True False 1652547.7384971506 1412806.0989225723 3152110.488033451 1.0 0.8549260429882634 1.9074247687997343 20.656260517969883 -6.872056149841823 1.1230969279628151 0.9168280861144592 1.9715392225769157 0.9666957598699231 0.08499489817815407 0.1349019560821349 0.3167623854335861 0.05865418801093548 0.13939067185650475 1.3425913665619343e-07 6.872056149841823 1.0547111364624566 K(ub)IQSQFTDAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KIQSQFTDAQK 11 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 2315680.0 792000.0 1038300.0 485380.0 True False 658583.0915490355 1032706.4718135854 586870.7138564471 1.0 1.5680731635313994 0.891111116254267 19.329005947117878 -6.6840690173421775 1.8869006003612474 1.3580828257077004 0.8935626273967047 0.3431611384836366 0.24054778280130582 0.42949924382738514 2.9597754037880715 0.10215191536859873 0.26807464982506435 2.0698123915797454e-07 6.6840690173421775 -0.4645201983109958 K(ub)IQSQFTDAQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIQSQFTDAQK 11 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 5982900.0 1089300.0 1819200.0 3074400.0 True False 1410120.3233131254 1717959.9207946786 2514890.746007907 1.0 1.2183073262558712 1.7834582655323243 20.427386840062333 -6.95470944927993 0.5045006250596046 0.9891101100399854 2.037218299151806 0.9995209117743504 0.0072258673411479055 0.0816479818711425 0.028549098311488875 0.00840403947500972 0.04662848100195166 1.109917121189434e-07 6.95470944927993 1.048108189111821 K(ub)IQVLQQQADDAEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KIQVLQQQADDAEER 15 1 P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;Q5VU61 P06753-2 TPM3 Tropomyosin alpha-3 chain 1 11236400.0 3814400.0 4646600.0 2775400.0 True False 5000715.338702142 3953345.392304941 2488228.2315166914 1.0 0.790555975403905 0.4975744594497299 22.253703052567758 -6.966391447529417 0.33330968341529216 1.0343446692615612 0.24414695880594783 0.999939019923408 0.0016090855396992192 0.07749191863349911 0.013212136573280662 0.004226110010818058 0.02548747730974525 1.0804596494280821e-07 6.966391447529417 -0.7901977104556134 down K(ub)IQVLQQQADDAEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIQVLQQQADDAEER 15 1 P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;Q5VU61 P06753-2 TPM3 Tropomyosin alpha-3 chain 1 16433800.0 5887400.0 4730100.0 5816300.0 True False 5700507.709599833 6618853.597145645 4292836.544740173 1.0 1.1610989642202025 0.7530621417300958 22.442658986409025 -6.799583279833592 1.457532794040966 1.0889318547522324 0.7474817623336963 0.8309722692053345 0.06898944477221106 0.22134766969866962 0.9283832852395307 0.03723692426055893 0.08662455054361211 1.5864146806428456e-07 6.799583279833592 -0.3414500924185361 K(ub)IQVLQQQADDAEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 KIQVLQQQADDAEER 15 1 P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;Q5VU61 P06753-2 TPM3 Tropomyosin alpha-3 chain 1 26588400.0 17796000.0 0.0 8792400.0 True False 26997833.061870333 0.0 7054578.2861541845 1.0 0.0 0.26130164854295396 24.686340280511672 -10.552035800046156 5.706937595446276 1.0024137401384503 0.13065082427162392 0.9365422807030784 0.10667595131305109 0.0032819114784761764 0.0002576124868074059 0.1034706311579768 0.034429515239689845 2.8052023881466244e-11 10.552035800046156 -0.8717629158668264 K(ub)IQVLQQQADDAEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KIQVLQQQADDAEER 15 1 P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;Q5VU61 P06753-2 TPM3 Tropomyosin alpha-3 chain 1 10578200.0 3814400.0 3294100.0 3469700.0 True False 5224686.760284096 3148555.769868005 2650228.320714585 1.0 0.6026305335282531 0.5072511410369178 22.31691311409065 -13.999999999999961 0.20044794182892803 3.2126941213358347 0.44558008728541904 0.9994869537704509 0.004833294710785062 12.539812365191404 0.14196133354526566 10.88050115125149 0.06053047330651254 1.00000000000009e-14 13.999999999999961 -2.7671140340504157 K(ub)IQVLQQQADDAEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KIQVLQQQADDAEER 15 1 P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;Q5VU61 P06753-2 TPM3 Tropomyosin alpha-3 chain 1 18122900.0 5887400.0 9981800.0 2253700.0 True False 4895633.956042668 9928026.06216783 2724938.25006855 1.0 2.0279347172011697 0.5566057990722868 22.2230642618433 -6.718853933232451 1.7633196810414977 1.626132330219914 0.5590236588980567 0.5071959705273047 0.4326189310212987 0.35752942107619895 2.1719093114029273 0.19484883120978833 0.4898260923130593 1.9104957097631872e-07 6.718853933232451 -1.0671086713218574 K(ub)IQVLQQQADDAEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIQVLQQQADDAEER 15 1 P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;Q5VU61 P06753-2 TPM3 Tropomyosin alpha-3 chain 1 49797000.0 17796000.0 26084000.0 5917000.0 True False 23037272.81160418 24632402.4703212 4840166.713546968 1.0 1.0692412540217666 0.21010154948153897 24.45746660260412 -6.887384499463675 1.0377612052873622 1.0490986360585344 0.1398940012762596 0.9791695926538013 0.056245636867987184 0.12128964542450642 0.23446465527089094 0.04143289253428586 0.1023637447334063 1.2960313309777286e-07 6.887384499463675 -0.9092046347822748 down K(ub)ISSDLDGHPVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KISSDLDGHPVPK 13 1 P29401;P29401-2;E9PFF2;F8W888 P29401 TKT Transketolase 1 12872900.0 4301100.0 5414300.0 3157500.0 True False 5638783.751911647 4606507.5447761 2830792.188878703 1.0 0.8169328258446537 0.5020217680663875 22.426952585794375 -6.962881522238148 0.3927181345844575 1.018764492630029 0.28882559729987084 0.9998625953473181 0.00241073585403757 0.07868740224593442 0.017442123172066826 0.004060313405890827 0.026459709146174522 1.0892271995714556e-07 6.962881522238148 -0.7299388953301582 K(ub)ISSDLDGHPVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KISSDLDGHPVPK 13 1 P29401;P29401-2;E9PFF2;F8W888 P29401 TKT Transketolase 1 18780100.0 5221300.0 7567300.0 5991500.0 True False 5055552.689495124 10588962.352948185 4422146.408852834 1.0 2.094521213269297 0.8747107745591421 22.269437390197677 -6.670238204062739 1.936755772907442 1.698504024768661 0.8796656792461751 0.27996849593676276 0.4649068546133213 0.4605942711350131 3.3311422808962994 0.19324324527978096 0.5160944580027947 2.1367897706296863e-07 6.670238204062739 -0.8188383455224858 K(ub)ISSDLDGHPVPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KISSDLDGHPVPK 13 1 P29401;P29401-2;E9PFF2;F8W888 P29401 TKT Transketolase 1 47999700.0 18133000.0 9290700.0 20576000.0 True False 27509086.699870456 7632701.996429576 16509144.581218826 1.0 0.2774611196548928 0.6001342306030308 24.71340490726661 -10.541459814700358 6.369879622057093 1.0006734008794884 0.4387976751304209 0.8013201009273654 0.13173074592323378 0.0012611656733371012 9.078569866189095e-05 0.12768828179907035 0.042515915428680426 2.8743535454508224e-11 10.541459814700358 -0.5618757257490675 K(ub)ISSDLDGHPVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KISSDLDGHPVPK 13 1 P29401;P29401-2;E9PFF2;F8W888 P29401 TKT Transketolase 1 13589700.0 4301100.0 5509900.0 3778700.0 True False 5891332.902857049 5266454.3991972655 2886248.884769342 1.0 0.8939325762160302 0.48991441026353005 22.490162647317266 -6.945999339746321 0.6011650016803087 1.0045392756845948 0.358584495546061 0.9988487405661084 0.007456657464084894 0.08513312797384143 0.04292557932787022 0.007644315074720828 0.033965592230470645 1.1324020848141288e-07 6.945999339746321 -0.6459547801385338 down K(ub)ISSDLDGHPVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KISSDLDGHPVPK 13 1 P29401;P29401-2;E9PFF2;F8W888 P29401 TKT Transketolase 1 18969800.0 5221300.0 11443000.0 2305500.0 True False 4341742.292809316 11381354.28774233 2787569.3905724105 1.0 2.621379510845644 0.6420393479339187 22.049842665631953 -6.688894008877973 1.8697389661681116 2.0174564341089196 0.6488067180934888 0.3657157149225998 0.685866642759906 0.4189344212498549 2.8385054830802385 0.2935118772650426 0.7655637298951381 2.0469441398098404e-07 6.688894008877973 -1.368649716015431 K(ub)ISSDLDGHPVPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KISSDLDGHPVPK 13 1 P29401;P29401-2;E9PFF2;F8W888 P29401 TKT Transketolase 1 39941000.0 18133000.0 10102000.0 11706000.0 True False 23473525.954867303 9539814.819628322 9575628.11370303 1.0 0.40640740713476897 0.4079330958678364 24.48453122935906 -10.040969631781541 5.624575905308564 1.0000023921636445 0.40717025150107544 0.9999950321517509 0.0006228598178569257 1.868450554316985e-08 3.185920566919175e-09 0.0006030838598265576 0.00020102714168182106 9.099769009128784e-11 10.040969631781541 -0.5928321406625691 K(ub)ITVPGNFQGHSGAQCITCSYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KITVPGNFQGHSGAQCITCSYK 22 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 12589200.0 3759600.0 4811700.0 4017900.0 True False 4866876.312795403 4543924.665175768 3286683.4271354363 1.0 0.9336429309348646 0.6753168184066 22.21456467963318 -6.94549858719838 0.6062586350437782 1.002874259170504 0.5927189206559111 0.9987989477677961 0.004853993182510863 0.08534535625432811 0.04384330560299625 0.004951605726849653 0.021754452425027045 1.1337085261620255e-07 6.94549858719838 -0.41015533851459285 K(ub)IVDQIRPDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KIVDQIRPDR 10 2 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 1 17936660.0 1981100.0 554560.0 15401000.0 True False 3005473.5378102497 455594.4352029435 12356985.599501908 1.0 0.15158823708522282 4.111493727708896 21.519160886992093 -6.850654275576874 1.231835517334743 0.5469705809108161 4.271886765123344 0.9412641362540246 0.4125734375214754 0.15673891103438178 0.4573376964116887 0.26202608167903524 0.6066373825546116 1.410411123385691e-07 6.850654275576874 3.7249161842125273 up K(ub)IVDQIRPDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIVDQIRPDR 10 2 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 1 16926400.0 1981100.0 2559300.0 12386000.0 True False 2564573.003319226 2416872.705194493 10131875.09109223 1.0 0.9424074503109989 3.950706444300452 21.290287209084543 -6.902536485691702 0.9450915623588632 0.8834810463916766 4.283263390360426 0.9877865835206437 0.15524476126661144 0.10956227354056373 0.16707627812392326 0.12258613259955711 0.3232056559332196 1.251594120428196e-07 6.902536485691702 3.399782343968749 up K(ub)IVEGISQPIWLVSDTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIVEGISQPIWLVSDTR 17 1 Q15126 Q15126 PMVK Phosphomevalonate kinase 1 9551300.0 2802000.0 3527200.0 3222100.0 True False 2713052.043737254 4935629.35410501 2378135.3490719707 1.0 1.8192166145497655 0.876553531128016 21.37148529203481 -6.676958684208738 1.9128772883206884 1.5197399989472637 0.8802363117120848 0.3102000585915936 0.3474371621609852 0.4453025890430915 3.14764457656174 0.14589120299234326 0.386257974003067 2.1039785883041238e-07 6.676958684208738 -0.6395036872351789 K(ub)K(ub)ESSVTEFISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KKESSVTEFISR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 2 8310600.0 3451900.0 2008800.0 2849900.0 True False 4525474.328247157 1709094.8702410709 2555019.686171153 1.0 0.37766093590968425 0.5645860523886308 22.109637582546835 -10.397100898917868 5.27347031669757 1.0003499320825344 0.4711234941491573 0.9143368105000521 0.07631185924733778 0.00031416182996817766 3.5917089009332296e-05 0.07393617813633181 0.024629546665248185 4.007735957444039e-11 10.397100898917868 -0.5292264379333771 K(ub)K(ub)ESSVTEFISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKESSVTEFISR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 2 10678200.0 3109600.0 3179900.0 4388700.0 True False 3010887.450108981 4449650.652959429 3239167.811822151 1.0 1.4778535321200301 1.0758182979257185 21.521757349055825 -10.073933563114931 5.939315329529779 0.9999991249723706 1.2768359150228896 0.38733046310057806 0.16413019706612092 1.9017193405539487e-06 2.9624390021366467e-07 0.15891888197054796 0.052972793320561054 8.43463778100606e-11 10.073933563114931 0.276836790050519 K(ub)K(ub)ESSVTEFISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KKESSVTEFISR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 2 9402800.0 3451900.0 2739200.0 3211700.0 True False 4728160.71408995 2618173.0866769166 2453162.6070377883 1.0 0.5537402903574626 0.5188407829977835 22.172847644069726 -13.999999999999998 0.3613358472341218 6.8877892070953886 0.5147185909710932 0.9997756991082005 0.003280764577698816 21.841863894287975 0.19437841139491632 99.22956747048683 0.010027041831391007 1.0000000000000041e-14 13.999999999999998 -6.373070616124295 K(ub)K(ub)ESSVTEFISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KKESSVTEFISR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 2 12118100.0 3109600.0 6133600.0 2874900.0 True False 2585770.1786374724 6100557.0793757215 3476028.2979642753 1.0 2.3592804688428677 1.3442912779649696 21.3021626244901 -10.130052276378086 4.7605508776387495 0.9999395990757569 1.8517858734098638 0.4842766694268176 0.41436760204087086 52332206.58700775 111358572.76545559 21562.282860721483 0.14184906943783868 7.412210145577845e-11 10.130052276378086 0.8518462743341069 K(ub)K(ub)ESSVTEFISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KKESSVTEFISR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 2 16431200.0 4412300.0 7711500.0 4307400.0 True False 5711809.329435881 7282348.2460467005 3523497.397656284 1.0 1.274963470597141 0.6168793799712283 22.445516389715596 -6.793209042192535 1.4834149835392232 1.1530391911114741 0.6092413964402957 0.8115712414110939 0.11714554119821748 0.2306029025153142 1.0023606308271638 0.0621467921156582 0.14517274813833328 1.6098705576892558e-07 6.793209042192535 -0.5437977946711784 K(ub)K(ub)LLADQAEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKLLADQAEAR 11 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 2 5844200.0 1211500.0 1828000.0 2804700.0 True False 1173041.5956415732 2557929.932894064 2070064.9308035595 1.0 2.1805961036659167 1.7646986590201656 20.16182274105534 -10.078882681853917 4.667927253767128 0.9999522033096108 1.972647381336595 0.8794092603154624 0.16978942086435952 117940999.56897967 5.744753968192733 61837.25220871199 0.05812343488379201 8.339064215191861e-11 10.078882681853917 0.9726951780269842 K(ub)KAEGGGGGGRPGAPAAGDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKAEGGGGGGRPGAPAAGDGK 21 3 Q00839 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 2473260.0 825260.0 1084900.0 563100.0 True False 799062.5730244862 1518106.227678761 415607.2173621009 1.0 1.899859008453698 0.5201184880791121 19.607948956635678 -6.730714849738207 1.7205023027316564 1.5411132521085777 0.52082125082366 0.5625484082926545 0.3782611423574842 0.33494178070531194 1.9426848373885468 0.17419769622404133 0.43193038437052195 1.8590246579732907e-07 6.730714849738207 -1.0202920012849177 K(ub)KDQVTAQEIFQDNHEDGPTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KKDQVTAQEIFQDNHEDGPTAK 22 2 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 15310900.0 4124700.0 5688900.0 5497300.0 True False 5339505.459992338 5372307.714054995 4496847.807061312 1.0 1.0061433131417201 0.8421843260120507 22.348274696357596 -6.8981955432417825 0.9726192393089731 1.0071584188341507 0.8255919166673669 0.9856465469630987 0.009091405358273573 0.11274524778400907 0.18501175157485536 0.007033766165370829 0.018140198038168662 1.2641670218462093e-07 6.8981955432417825 -0.18156650216678383 K(ub)KDTQGFGEESR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KKDTQGFGEESR 12 2 E9PP42;E9PNA8;E9PLH2;M0QYU9;M0R0R3;M0R2G5;B7WNH4;Q9BQ49 E9PP42 SMIM7 Small integral membrane protein 7 1 5361570.0 356470.0 2367700.0 2637400.0 True False 540791.0514477917 1945165.436075462 2116116.7339865156 1.0 3.5968890958308495 3.9130024957352805 19.044711753759007 -10.052815459993406 0.4876748694025043 1.502623213539328e-18 3.908300891139121 0.9992296214276055 0.036223684699805705 1.3501712132067074 0.22350090283353571 2.029104739350341 0.06552507332571221 8.854917922489347e-11 10.052815459993406 3.908300891139121 K(ub)KDTQGFGEESR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KKDTQGFGEESR 12 2 E9PP42;E9PNA8;E9PLH2;M0QYU9;M0R0R3;M0R2G5;B7WNH4;Q9BQ49 E9PP42 SMIM7 Small integral membrane protein 7 1 2542970.0 356470.0 1143700.0 1042800.0 True False 461457.4420742037 1080052.0896069007 853021.1000315669 1.0 2.340523721433937 1.8485368795816248 18.815838075851456 -10.346860558712386 5.343179151388065 0.9996456872881481 2.094530300507818 0.8684061608451689 0.2008527871170505 0.0008480048304533058 0.0001036581947592807 0.19453407829424424 0.06482495829528807 4.499242913399529e-11 10.346860558712386 1.09488461321967 K(ub)KEAEQVLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KKEAEQVLQK 10 2 Q8WV22;I3L1I3;H3BV05 Q8WV22 NSMCE1 Non-structural maintenance of chromosomes element 1 homolog 1 4368500.0 1210900.0 1876600.0 1281000.0 True False 1587501.6263722803 1596618.5949295056 1148454.4082196732 1.0 1.0057429664359205 0.7234351065479492 20.59832663922978 -6.902256955980346 0.9468809143733004 1.0110215909416609 0.6924046617455064 0.9876563281687389 0.014637523767350101 0.10976328314543826 0.16819489086237419 0.011542912422929496 0.030387760512283323 1.2523999569592741e-07 6.902256955980346 -0.3186169291961545 K(ub)KEAEQVLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KKEAEQVLQK 10 2 Q8WV22;I3L1I3;H3BV05 Q8WV22 NSMCE1 Non-structural maintenance of chromosomes element 1 homolog 1 4551600.0 1210900.0 1610800.0 1729900.0 True False 1658602.453342076 1539629.5297967226 1321333.24840884 1.0 0.9282691742643794 0.796654584554822 20.66153670075267 -6.961694904361537 0.4108510191002198 1.006423572235369 0.7136090733958027 0.999827978312947 0.0011044163879332348 0.07910114893917246 0.018934652850902768 0.00169519229445224 0.010985820980394467 1.0922073521329145e-07 6.961694904361537 -0.29281449883956623 K(ub)KEEVGVEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KKEEVGVEVK 10 2 H0YHF6;Q4G104;O94952-1;O94952;H0YIE9 H0YHF6 FBXO21 F-box only protein 21 1 5414170.0 2066200.0 2450400.0 897570.0 True False 2708808.20910926 2084809.8715843875 804698.0664994013 1.0 0.7696410046948055 0.29706719870138426 21.369226819799454 -6.959544768518657 0.44180196070910677 1.0165832513297939 0.031644724338237604 0.999752943067712 0.004599015563121457 0.0798641318387759 0.021735135457711486 0.006244827633929054 0.03914260128030911 1.0976281372851484e-07 6.959544768518657 -0.9849385269915563 down K(ub)KEEVGVEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKEEVGVEVK 10 2 H0YHF6;Q4G104;O94952-1;O94952;H0YIE9 H0YHF6 FBXO21 F-box only protein 21 1 4310970.0 1279500.0 1139400.0 1892070.0 True False 1238882.9728628907 1594368.361892506 1396480.1061166946 1.0 1.2869402492538393 1.1272090558235845 20.240608483643438 -10.213211392348196 4.0460381226365625 0.9998652631955577 1.2070746525686271 0.6914391485619187 0.06520998674817625 45900584.97794623 14.24051237365853 58051.35673499668 0.022323112933779803 6.120524033923487e-11 10.213211392348196 0.20720938937306943 K(ub)KEEVGVEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KKEEVGVEVK 10 2 H0YHF6;Q4G104;O94952-1;O94952;H0YIE9 H0YHF6 FBXO21 F-box only protein 21 1 10119000.0 3637200.0 3433100.0 3048700.0 True False 5517898.314937887 2820436.482067268 2446123.1087073223 1.0 0.5111432507612306 0.443307029070335 22.395687439954006 -13.999999999999998 0.2782527066090602 4.946046743067375 0.42253127018023806 0.9996013174078412 0.004951615041259162 15.304545079842631 0.16707536859831587 34.331503358176114 0.027058765414442753 1.0000000000000041e-14 13.999999999999998 -4.523515472887136 K(ub)KEEVGVEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KKEEVGVEVK 10 2 H0YHF6;Q4G104;O94952-1;O94952;H0YIE9 H0YHF6 FBXO21 F-box only protein 21 1 5201420.0 1279500.0 3460900.0 461020.0 True False 1063960.941460847 3442255.4447651342 557417.1504843606 1.0 3.2353212515854435 0.5239075315293171 20.021013759077714 -6.687691602938935 1.8741334867544415 2.404431928706947 0.5334246434299303 0.35973135391093225 0.94583505297877 0.4217233435350967 2.869922158273285 0.4039623508689751 1.0552055447744522 2.0526192478545245e-07 6.687691602938935 -1.8710072852770168 K(ub)KEEVGVEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KKEEVGVEVK 10 2 H0YHF6;Q4G104;O94952-1;O94952;H0YIE9 H0YHF6 FBXO21 F-box only protein 21 1 7940800.0 3637200.0 2697100.0 1606500.0 True False 4708427.099930692 2547004.014058557 1314133.4840820027 1.0 0.5409458318035865 0.2791024382858867 22.166813762046456 -8.928260724580483 0.19922852465047625 1.3859311604403566 4.3361816287628284e-14 0.999607457559063 0.005903253430228922 0.4129185780025606 0.06326949248729746 0.24055284135519972 0.13755063871452514 1.1796122539893119e-09 8.928260724580483 -1.3859311604403133 down K(ub)KEGVILTNESAASTGQPDNDVTEGQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KKEGVILTNESAASTGQPDNDVTEGQR 27 2 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 1 17191800.0 1373300.0 3223500.0 12595000.0 True False 1777763.921790064 3044109.391315767 10302839.235613318 1.0 1.7123248784633878 5.795392239279552 20.761632323482864 -6.936809310327163 0.6886048327388716 0.9506695476347163 6.800272053732686 0.9977154422437214 0.10098474475650918 0.08925281027635305 0.06146665999302974 0.09606953980038047 0.35664072265311403 1.1566199784883355e-07 6.936809310327163 5.84960250609797 K(ub)KELVNNLGEIYQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKELVNNLGEIYQK 14 2 A0A024R571;Q9H4M9;C9JC03;C9J2Z4 A0A024R571 EHD1 EH domain-containing protein 1 1 9968600.0 3210100.0 4763900.0 1994600.0 True False 3108197.1326199025 6666150.113410303 1472154.4232826282 1.0 2.14469991090668 0.47363611781011705 21.567646576684357 -6.722302560534337 1.750782600276097 1.6946910758123648 0.47585270033175064 0.5234717943806877 0.48156256646251555 0.3508633796311672 2.1029982870494397 0.21828277321784048 0.546544187479316 1.8953850006641657e-07 6.722302560534337 -1.218838375480614 K(ub)KESILDLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KKESILDLSK 10 2 Q9UK45;K7ENY5;K7EML7 Q9UK45 LSM7 U6 snRNA-associated Sm-like protein LSm7 1 8199500.0 3143200.0 3804200.0 1252100.0 True False 4120765.6387921 3236628.188655455 1122544.7029912993 1.0 0.78544340357201 0.2724116830192618 21.974480984564284 -6.956409084214064 0.4833972602216091 1.0119290147621713 0.0244133896502075 0.9996129434870515 0.0060054915378614186 0.08100978795516726 0.026067871017627895 0.007284182564421061 0.04231653741633379 1.1055818891460093e-07 6.956409084214064 -0.9875156251119639 down K(ub)KESILDLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKESILDLSK 10 2 Q9UK45;K7ENY5;K7EML7 Q9UK45 LSM7 U6 snRNA-associated Sm-like protein LSm7 1 16342900.0 6220000.0 7089500.0 3033400.0 True False 6022549.504655864 9920374.321254093 2238861.53995063 1.0 1.647205110324943 0.3717464735192013 22.521942916621956 -6.768749355841302 1.5791921548250267 1.3718075070234408 0.36489946933570055 0.7257883736678417 0.2726777275088175 0.26844782155734154 1.3210211935632243 0.13611655267058598 0.32439350668619976 1.7031411578204307e-07 6.768749355841302 -1.0069080376877402 K(ub)KESILDLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KKESILDLSK 10 2 Q9UK45;K7ENY5;K7EML7 Q9UK45 LSM7 U6 snRNA-associated Sm-like protein LSm7 1 9712600.0 5397500.0 1772800.0 2542300.0 True False 8188402.110105912 1456429.9890503786 2039813.2906703246 1.0 0.17786498140496676 0.2491100538593287 22.96515052024575 -10.42399831507295 6.942933689504384 1.000078806234338 0.21348751897906934 0.993883609081256 0.02908567903346734 3.548388459466235e-05 2.9438294383280566e-06 0.028164864402795052 0.009387362542479443 3.7670526047991776e-11 10.42399831507295 -0.7865912872552686 K(ub)KESILDLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KKESILDLSK 10 2 Q9UK45;K7ENY5;K7EML7 Q9UK45 LSM7 U6 snRNA-associated Sm-like protein LSm7 1 7879870.0 3143200.0 3912300.0 824370.0 True False 4305325.981786122 3739441.649753986 629670.7844330871 1.0 0.8685617919697288 0.1462539159861386 22.037691046087176 -6.986959093483201 0.7128699296186464 1.0059528453444402 1.2576833226062354e-25 0.9977659481882262 0.017740490577501513 0.08031513660982781 0.06245648242623663 0.01701865189752083 0.05593734860715883 1.0304831778393272e-07 6.986959093483201 -1.0059528453444402 down K(ub)KESILDLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KKESILDLSK 10 2 Q9UK45;K7ENY5;K7EML7 Q9UK45 LSM7 U6 snRNA-associated Sm-like protein LSm7 1 17558500.0 6220000.0 10222000.0 1116500.0 True False 5172205.592720958 10166932.057091866 1349954.9878872691 1.0 1.9656859873088137 0.2610018035221013 22.302348192056233 -6.752994429766125 1.6385216887497644 1.5657668343552271 0.2567704897436897 0.6618791854622612 0.4058639493519086 0.29483663162332585 1.5582313816404136 0.19559118012397228 0.47340431972773483 1.76606047192211e-07 6.752994429766125 -1.3089963446115374 K(ub)KESSVTEFISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KKESSVTEFISR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 26590800.0 7595200.0 9230700.0 9764900.0 True False 9957380.752021438 7853515.540986776 8754521.819534957 1.0 0.7887129895472202 0.8791992630951379 23.24733486653503 -10.122938710413486 4.520434486312053 1.0000166949038791 0.8339561263168224 0.8178412698370208 0.03694086651135217 51544872.50761855 0.46282397993259794 9662.82482190713 0.012645841172478115 7.534618881544429e-11 10.122938710413486 -0.16606056858705676 K(ub)KESSVTEFISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKESSVTEFISR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 38382100.0 7048100.0 11186000.0 20148000.0 True False 6824361.923434887 15652628.134219395 14870634.372956181 1.0 2.293639802494678 2.1790512490098686 22.702262729945605 -10.208231666986876 5.343354870117962 0.9999273166646407 2.2363455257524976 0.9935985996095152 0.046780581067701554 4.050852499807265e-05 6.0025916140683126e-06 0.045297729345377936 0.015098367616643746 6.191107329119613e-11 10.208231666986876 1.2364182090878568 K(ub)KESSVTEFISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KKESSVTEFISR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 97313700.0 19944900.0 18006000.0 59362800.0 True False 30257871.467503797 14792688.61847988 47629716.560360424 1.0 0.4888872845655009 1.5741264752054207 24.850807166925314 -6.7786400269928 1.5411263524831953 0.7100764754479022 1.5823627888900407 0.7625277095711482 0.21602310914976933 0.25271288776905 1.1854330541212859 0.11041156086487762 0.2608273287271705 1.6647919722449686e-07 6.7786400269928 0.8722863134421385 K(ub)KESSVTEFISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KKESSVTEFISR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 28766400.0 7595200.0 9819200.0 11352000.0 True False 10403350.692562351 9385355.276247822 8670891.401778813 1.0 0.9021473517140662 0.8334710285194825 23.310544928057922 -6.974925006426368 0.07573799980003393 1.2614816006699026 0.47241685299282116 0.9999999127353884 1.9342418496662596e-05 0.07473475410396886 0.0021921685255584205 0.008847995201178585 0.013906929476984796 1.0594366519343926e-07 6.974925006426368 -0.7890647476770813 K(ub)KESSVTEFISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KKESSVTEFISR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 35039600.0 7048100.0 18878000.0 9113500.0 True False 5860807.433771156 18776300.467010394 11019090.713936968 1.0 3.2037054073501134 1.8801318484621663 22.48266800537988 -10.320784741769158 5.977736205498484 0.9998657569650925 2.541918627906142 0.6440684193410867 0.540346642719184 0.0009668058965969211 0.00010985256065499262 0.5232321267078749 0.17439612903587284 4.7776601989691473e-11 10.320784741769158 1.5420528709410495 K(ub)KESSVTEFISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KKESSVTEFISR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 56861800.0 19944900.0 2959600.0 33957300.0 True False 25819066.222755913 2794895.658302509 27777419.831321385 1.0 0.10824929275866677 1.0758491260555139 24.621933489017763 -12.152797286826658 15.170879448665803 0.9509211008862118 0.6328442884663813 0.0 0.4495392130321553 0.0 0.0 0.0 0.13086349824337778 7.034005655656609e-13 12.152797286826658 -0.31807681241983055 K(ub)KEVDATSPAPSTSSTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKEVDATSPAPSTSSTVK 18 2 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 43857700.0 3839400.0 5120300.0 34898000.0 True False 3717520.348581309 7164862.492011758 25757166.882441167 1.0 1.9273230057089086 6.928588001480797 21.825909208499514 -6.938131429447035 0.6767231918259085 0.941634361735477 8.206231124988303 0.9979087798280659 0.11907410954246551 0.08862951599678542 0.05856962068440012 0.1143301533086829 0.4341119197742946 1.1531042439752652e-07 6.938131429447035 7.264596763252826 K(ub)KEVDATSPAPSTSSTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KKEVDATSPAPSTSSTVK 18 2 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 364875730.0 718580.0 8738150.0 355419000.0 True False 1090138.395234814 7178758.861022426 285170278.8643186 1.0 6.585181195710599 261.5908953494785 20.056079868954505 -7.268090641288286 1.6199795815521163 2.597790937673778 199.99999999999997 0.9080087560059961 36.865784016817045 0.1563637757686067 0.8357631770398711 26.621215740930417 23.59199160190058 5.393980333915781e-08 7.268090641288286 197.4022090623262 K(ub)KEVDATSPAPSTSSTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KKEVDATSPAPSTSSTVK 18 2 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 29304370.0 3839400.0 6295400.0 19169570.0 True False 3192631.2142593022 6261485.430660942 23177838.456922695 1.0 1.9612304116727182 7.25979197140062 21.60631448393379 -6.937654950922519 0.6810297123688762 0.9374245635699213 8.595184722238436 0.9978403410199086 0.12791210958454938 0.08885293627592504 0.059604629157012055 0.1224026278412069 0.46094622604654883 1.1543700461908879e-07 6.937654950922519 7.6577601586685144 K(ub)KEVDATSPAPSTSSTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KKEVDATSPAPSTSSTVK 18 2 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 702323250.0 718580.0 7414970.0 694189700.0 True False 930215.9753294281 7002320.401217519 567854297.587825 1.0 7.527628622737539 610.4542521823754 19.827206191046955 -7.701227956126619 4.08900463016477 0.005615133078076157 199.99999999999997 0.31229098877998385 236.9867504082206 0.6195807494847286 21.11674784978085 219.32207314556143 108.52106341014819 1.9896287318602017e-08 7.701227956126619 199.9943848669219 K(ub)KLEQLYNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KKLEQLYNR 9 2 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 38433100.0 12965000.0 15765000.0 9703100.0 True False 16997240.5532386 13412923.451488677 8699116.290707514 1.0 0.7891235880010548 0.5117957978802631 24.018797212733617 -6.967351118330181 0.3151080763680585 1.0402275714359683 0.25181074898375555 0.9999537260058753 0.0013599638766361693 0.0771719968757476 0.012092714187847095 0.00429033045418948 0.024502591795652114 1.0780747680902404e-07 6.967351118330181 -0.7884168224522128 K(ub)KLEQLYNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKLEQLYNR 9 2 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 56230000.0 11973000.0 22617000.0 21640000.0 True False 11592923.668688862 31648086.04609687 15971834.813915597 1.0 2.7299486264689783 1.3777227617786931 23.46674111583642 -6.584211615367866 2.2507620269162394 2.175033675808779 1.381310097809337 0.0 0.7507391526084239 0.6866462780949553 6.548891694102254 0.27937584294803824 0.8381512373940025 2.6048839787198043e-07 6.584211615367866 -0.7937235779994423 K(ub)KLEQLYNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KKLEQLYNR 9 2 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 47696000.0 18525000.0 14702000.0 14469000.0 True False 28103779.358909167 12078313.232749693 11609195.808012024 1.0 0.42977540773073114 0.4130830825189993 24.744260819416443 K(ub)KLEQLYNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KKLEQLYNR 9 2 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 37240000.0 12965000.0 14086000.0 10189000.0 True False 17758510.865950964 13463633.943827048 7782568.049041959 1.0 0.7581510660131622 0.4382444061773084 24.082007274256508 -6.967262646421419 0.31682615807324016 1.0454752947752721 0.14064973706224876 0.9999524759365384 0.0015860569136765244 0.07720133745392796 0.012195221023608125 0.004913093785221801 0.0282200099371785 1.0782944094907477e-07 6.967262646421419 -0.9048255577130233 down K(ub)KLEQLYNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KKLEQLYNR 9 2 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 60125200.0 11973000.0 40759000.0 7393200.0 True False 9956079.993834097 40539423.1769719 8939083.937705474 1.0 4.071825779029335 0.8978517592507835 23.247146391270697 -6.6536149217271126 1.9955277081625353 2.9875750117920363 0.9111602281025675 0.2088776935719403 1.3099291218233007 0.4997363967659459 3.81840098336245 0.5316079277657769 1.451335555360755 2.2201641124229015e-07 6.6536149217271126 -2.0764147836894686 K(ub)KLEQLYNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KKLEQLYNR 9 2 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 46054000.0 18525000.0 14766000.0 12763000.0 True False 23980977.6823425 13944259.1196428 10440264.959438909 1.0 0.5814716691017204 0.43535610172917216 24.515387141508892 -13.999999999999995 0.14672794967626393 3.0142596389080145 0.2683913231980256 0.9995775255202041 0.004918412635448107 11.946953779553443 0.12045932390524436 6.868412186991736 0.1500412389579613 1.0000000000000123e-14 13.999999999999995 -2.745868315709989 K(ub)KLLADQAEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KKLLADQAEAR 11 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 6557800.0 1379100.0 2888200.0 2290500.0 True False 1808013.4552233987 2457291.8181154258 2053501.0320274509 1.0 1.3591114662428228 1.1357775165305501 20.785973983643558 -10.121697998487768 4.123838863104371 0.9999422430167414 1.247444491279231 0.6207465741309603 0.09117570335568799 12699678.610267565 10415021.489591638 5880.823944195122 0.03121186778841458 7.556174894632951e-11 10.121697998487768 0.24750224826248968 K(ub)KLLADQAEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKLLADQAEAR 11 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 14450600.0 4847500.0 4529600.0 5073500.0 True False 4693618.765887346 6338292.901551945 3744598.148262517 1.0 1.3504064172441723 0.7978061992332662 22.162269234598146 -6.735339219108448 1.7035756365235661 1.2096039875116946 0.7977880569499961 0.58394085766037 0.14725106298677879 0.3263052983327131 1.857490201253794 0.06842981285157979 0.168799369232647 1.8393347710562765e-07 6.735339219108448 -0.4118159305616985 K(ub)KLLADQAEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KKLLADQAEAR 11 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 20301400.0 4360200.0 4520200.0 11421000.0 True False 6614742.173317985 3713534.993516206 9163634.34399788 1.0 0.5614028326751064 1.3853350748818922 22.65725349415396 -6.7621148663681705 1.6047654402487537 0.7459068949222303 1.3886373182386904 0.6994520942353819 0.18453340195733078 0.2793749756809134 1.4184981636724545 0.0907133616395264 0.2175233810200706 1.7293589012996993e-07 6.7621148663681705 0.6427304233164601 K(ub)KLLADQAEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KKLLADQAEAR 11 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 6365400.0 1379100.0 2088500.0 2897800.0 True False 1888990.5387761653 1996223.1642540675 2213399.3220643643 1.0 1.056767158583746 1.171736584503158 20.84918404516645 -6.959798391277906 0.43826588111021325 0.9958140619179263 1.2371592906940572 0.9997626424185895 0.001100629489896386 0.07977322149947579 0.02139801133723381 0.001512602747772186 0.009529125165509668 1.0969873227735143e-07 6.959798391277906 0.24134522877613085 K(ub)KLLADQAEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KKLLADQAEAR 11 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 12431700.0 4847500.0 6029000.0 1555200.0 True False 4030911.030661549 5996520.580337203 1880385.1295676504 1.0 1.4876340695004275 0.4664913502839192 21.942674510032422 -6.776846630511002 1.5480107573031203 1.2772496552854944 0.45917149512796207 0.7560798140416323 0.2059589772425858 0.25552925526583065 1.209216737880734 0.10481132602287035 0.24798560929995975 1.6716808579916436e-07 6.776846630511002 -0.8180781601575323 down K(ub)KLLADQAEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KKLLADQAEAR 11 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 16544000.0 4360200.0 6031800.0 6152000.0 True False 5644364.852391346 5696125.0276216725 5032399.124850593 1.0 1.0091702390940225 0.8915793462073093 22.42837981624641 -6.888059471668301 1.0338232489694554 1.0066153805114884 0.8818428393646026 0.9796257897769264 0.007622623178262202 0.12073051495164235 0.23117264445998087 0.005631953337272782 0.013945577922594701 1.2940186282471856e-07 6.888059471668301 -0.12477254114688574 K(ub)KNLQYYDISAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KKNLQYYDISAK 12 2 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 1 14627200.0 5073900.0 5691000.0 3862300.0 True False 6651932.035717494 4841924.9833442485 3462666.2457976914 1.0 0.7278975427508237 0.5205504546957085 22.66534199768564 -7.236552801082164 0.1399392263538402 1.2973511874374544 1.2465999263823973e-09 0.9999968652142113 0.00034755832027743883 0.09786545039081813 0.006923180671658824 0.02086040726223951 0.04066856003576172 5.8002564930618675e-08 7.236552801082164 -1.2973511861908544 K(ub)KNLQYYDISAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKNLQYYDISAK 12 2 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 1 23788600.0 7183200.0 8168100.0 8437300.0 True False 6955173.247884892 11429664.926078781 6227318.016425609 1.0 1.6433328860003031 0.8953505246356547 22.729655020935887 -6.679101228647928 1.9049315247145409 1.4073819447785283 0.8982120506212877 0.31996329013465163 0.2727156509732246 0.4405930989471476 3.0903158630744225 0.11490371487546337 0.30341679469382443 2.0936244011372622e-07 6.679101228647928 -0.5091698941572406 K(ub)KNLQYYDISAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KKNLQYYDISAK 12 2 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 1 24190900.0 7547700.0 8539500.0 8103700.0 True False 11450412.710782113 7015559.505581962 6502000.143022115 1.0 0.612690536383537 0.567839806935483 23.44889626297639 -13.999999999999998 0.30425105388413215 4.620644062017086 0.557282806022539 0.9996592925796872 0.003581208048301079 16.87054406279627 0.1753057036659061 38.54561350569216 0.01591801099355615 1.0000000000000041e-14 13.999999999999998 -4.063361255994547 K(ub)KNLQYYDISAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KKNLQYYDISAK 12 2 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 1 13864800.0 5073900.0 5028400.0 3762500.0 True False 6949857.94699179 4806228.6613048455 2873874.9911198705 1.0 0.6915578272193602 0.4135156449296654 22.728552059208532 -7.17433188761966 0.2129148099599857 1.153158224915391 2.197333707194498e-10 0.9999862794078436 0.0008872631181926927 0.08677346552863918 0.009543497268665185 0.012233736834023424 0.03559770080640746 6.693728794993874e-08 7.17433188761966 -1.1531582246956578 down K(ub)KNLQYYDISAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KKNLQYYDISAK 12 2 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 1 26046500.0 7183200.0 15990000.0 2873300.0 True False 5973149.06971595 15903858.696233502 3474093.745361836 1.0 2.6625584780508085 0.5816184570004453 22.510060296370163 -6.693949084110379 1.8525492778372123 2.0384644855566463 0.5884936864165398 0.38884344542503935 0.7025963896804328 0.4082654439583612 2.7195728087469173 0.30307214426254275 0.7852668566702092 2.0232563676450228e-07 6.693949084110379 -1.4499707991401065 K(ub)KNLQYYDISAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KKNLQYYDISAK 12 2 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 1 20204700.0 7547700.0 10030000.0 2627000.0 True False 9770646.437409792 9471821.682921391 2148912.955296247 1.0 0.9694160712494658 0.21993559679618555 23.22002258506884 -6.915489285553664 0.8575199839223139 1.019375097385656 0.11078462385220753 0.9928331114899107 0.030538773425197854 0.10089957025142367 0.11990782465865282 0.025701868999714845 0.07396034564977493 1.2148165907498093e-07 6.915489285553664 -0.9085904735334484 down K(ub)KPNATRPVTPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKPNATRPVTPPR 13 3 P36873;P36873-2;F8W0W8 P36873 PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase 1 1474700.0 515170.0 412200.0 547330.0 True False 498816.21033980034 576793.609594603 403967.8534519605 1.0 1.156324910134102 0.8098530983521408 18.928148824521863 -6.784044376765884 1.520095629161357 1.088050437625395 0.8067514405041002 0.7814437347221531 0.06623119240460312 0.24434157567447082 1.1153843995864572 0.03430837213333124 0.08068466939357183 1.6442037077922775e-07 6.784044376765884 -0.2812989971212948 K(ub)KPNATRPVTPPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KKPNATRPVTPPR 13 3 P36873;P36873-2;F8W0W8 P36873 PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase 1 4094010.0 473430.0 807580.0 2813000.0 True False 718227.9223691422 663461.0393486609 2257009.3170183036 1.0 0.9237472098831417 3.1424694678721856 19.454082215827626 -6.898941860238341 0.9679492418672797 0.9050562484154384 3.3704080649068278 0.986031998595927 0.12154444601666488 0.11218781441240133 0.18185229142258344 0.09436333834684613 0.24423524001764804 1.2619964689565575e-07 6.898941860238341 2.4653518164913892 up K(ub)KPNATRPVTPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KKPNATRPVTPPR 13 3 P36873;P36873-2;F8W0W8 P36873 PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase 1 837010.0 170130.0 333810.0 333070.0 True False 233031.65859037667 319061.1704379463 254405.72579197242 1.0 1.3691752115054563 1.0917217314200518 17.830166440426627 -9.993619258401756 5.8624290144582005 0.999999709773027 1.2304484714628086 0.4791196715316377 0.11326990892830902 4.297579963719946e-07 7.387367061196688e-08 0.10967325663663863 0.03655770590878609 1.0148006613893918e-10 9.993619258401756 0.23044876168978157 K(ub)KPNATRPVTPPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KKPNATRPVTPPR 13 3 P36873;P36873-2;F8W0W8 P36873 PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase 1 3054900.0 473430.0 660970.0 1920500.0 True False 612864.4677004806 624186.4384606744 1570988.7059940759 1.0 1.0184738573647039 2.563354197851539 19.225208537920075 -6.909510755551069 0.8990611249490907 0.9514241926903543 2.7609280795579476 0.9907356067451139 0.07051946844723947 0.10474240086546918 0.140529100701948 0.05759593652347906 0.15845683912630745 1.2316554827066523e-07 6.909510755551069 1.8095038868675934 up K(ub)KQDPPVTHDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKQDPPVTHDLR 12 2 P25685;M0R080;P25685-2;M0QXK0;M0QYT3;M0QZD0;M0R1D6;M0R128;A0A1B0GX60 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 2553220.0 906160.0 882280.0 764780.0 True False 877394.4468069058 1234579.0050294176 564461.1750917918 1.0 1.4070968986895354 0.643337984581542 19.742866049736865 -6.761930003933315 1.6054597556169325 1.2358993914358016 0.6403028763980924 0.6987023470738264 0.17127498767027682 0.27968591629971357 1.4212668264522528 0.08416084751681221 0.20184763910071546 1.7300951794722713e-07 6.761930003933315 -0.5955965150377093 K(ub)KQDPPVTHDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KKQDPPVTHDLR 12 2 P25685;M0R080;P25685-2;M0QXK0;M0QYT3;M0QZD0;M0R1D6;M0R128;A0A1B0GX60 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 2157770.0 906160.0 833850.0 417760.0 True False 753512.189694537 829357.8845437344 505111.68449600163 1.0 1.1006562281095202 0.6703430832363397 19.52327132517114 -6.845074749604764 1.2585658936301243 1.0535676974480446 0.6547028499630516 0.932831297427686 0.047630044296046996 0.16296257170183534 0.49920691894652275 0.029646619294424345 0.06842446765595832 1.4286480422681743e-07 6.845074749604764 -0.39886484748499296 K(ub)KSPNELVDDLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KKSPNELVDDLFK 13 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 15701100.0 5239500.0 7749300.0 2712300.0 True False 6869035.23939018 6593134.646534816 2431657.2142187483 1.0 0.9598341567279748 0.35400272810867484 22.71167605510898 -6.9203584358368655 0.8220714658525158 1.0131955867017137 0.25549942733056435 0.9942796974702874 0.022350526518588463 0.09796150971276042 0.10452744807430144 0.019293836459297553 0.057993070763854696 1.2012725802555007e-07 6.9203584358368655 -0.7576961593711493 down K(ub)KSPNELVDDLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKSPNELVDDLFK 13 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 27813800.0 11591800.0 8471200.0 7750800.0 True False 11223824.654030524 11853794.336724421 5720632.960984143 1.0 1.0561278977632345 0.5096865941263471 23.420061039727404 -6.881571819303374 1.071032372604383 1.0355624372615695 0.46978016138401785 0.9749297429583036 0.03886155175259719 0.1262451192217237 0.26397048044269994 0.02791061941130948 0.06777058184706734 1.3134942643770285e-07 6.881571819303374 -0.5657822758775517 K(ub)KSPNELVDDLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KKSPNELVDDLFK 13 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 43439600.0 14098700.0 11632800.0 17708100.0 True False 21388758.65303386 9556835.952518756 14208086.273264041 1.0 0.4468158301072409 0.6642782081815073 24.35034941894076 -10.210260915631197 5.462338539066676 1.0000215776223043 0.5555470191443328 0.8477831693546882 0.08877864408917882 2.3329928260745762e-05 3.3730848021011566e-06 0.0859637193367947 0.02865318417133321 6.162246748968965e-11 10.210260915631197 -0.44447455847797146 K(ub)KSPNELVDDLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KKSPNELVDDLFK 13 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 11910300.0 5239500.0 4784900.0 1885900.0 True False 7176684.742163526 4573487.296451663 1440489.2613296912 1.0 0.6372701965828461 0.20071792381609238 22.774886116631873 -7.460149324207676 0.39680373475410474 1.0376899898345024 1.718262098250303e-13 0.9990768127524728 0.009928550734817519 0.11704929501287463 0.044262071781689345 0.017721285907082197 0.06380974338984359 3.46617651826961e-08 7.460149324207676 -1.0376899898343306 down K(ub)KSPNELVDDLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KKSPNELVDDLFK 13 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 28015100.0 11591800.0 14908400.0 1514900.0 True False 9639095.303810742 14828085.49011431 1831658.5858937965 1.0 1.5383275113227837 0.19002391076781494 23.20046631516168 -6.798319778103456 1.4626023719778067 1.2976348727095872 0.1721225126916941 0.8273168371938422 0.23027962133237315 0.2231203041423431 0.9424484073989805 0.12387045219570454 0.2883974467955356 1.5910367893332283e-07 6.798319778103456 -1.1255123600178931 down K(ub)KSPNELVDDLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KKSPNELVDDLFK 13 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 40787700.0 14098700.0 24803000.0 1886000.0 True False 18251045.076925337 23422691.246410746 1542767.3519941827 1.0 1.283361645740708 0.08453035678185312 24.12147574103321 -6.8443758082612405 1.2618637734098757 1.150771840153088 0.041545786021700684 0.9317223340784405 0.13368003223418068 0.16375392687061563 0.5045906015678058 0.08300175993044061 0.19151109337301916 1.430949119456626e-07 6.8443758082612405 -1.1092260541313872 down K(ub)KYEPPVPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKYEPPVPTR 10 2 P62191 P62191 PSMC1 26S protease regulatory subunit 4 1 5353300.0 599940.0 767660.0 3985700.0 True False 580895.2330905532 1074190.6412940146 2941725.601563005 1.0 1.8491985819524943 5.064124189678851 19.147918465381828 -6.946139990907022 0.599726702367735 0.9637667238546074 6.114051995429341 0.9988624928009205 0.0590344646994614 0.08507376594005767 0.042669694522721714 0.06060585931663207 0.2701500808405461 1.1320354030216062e-07 6.946139990907022 5.150285271574734 K(ub)KYPDRVPVIVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KKYPDRVPVIVEK 13 3 H6UMI1;O95166;F5GZY7;Q9H0R8;Q9H0R8-2 H6UMI1 GABARAP;GABARAPL1 Gamma-aminobutyric acid receptor-associated protein;Gamma-aminobutyric acid receptor-associated protein-like 1 1 20974600.0 14733000.0 3377800.0 2863800.0 True False 22351038.126575373 2775005.1991281398 2297768.6747518694 1.0 0.12415553959566021 0.10280366673527452 24.41383850525235 K(ub)LADEVITR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLADEVITR 9 1 Q58WW2;Q58WW2-2;Q58WW2-4;Q58WW2-3 Q58WW2 DCAF6 DDB1- and CUL4-associated factor 6 1 4713270.0 946170.0 1285200.0 2481900.0 True False 916134.3512572728 1798387.0622294624 1831815.9345959863 1.0 1.9630167341301141 1.9995057843667385 19.805199659745345 -11.003252148468164 0.5682198347469833 2.1197013386723025e-09 1.9958821193039744 0.9998855832237733 0.004950488308404392 2.876741372757847 0.2787136132257441 3.767990468510479 0.00662841945672799 9.925396192447628e-12 11.003252148468164 1.995882117184273 K(ub)LADEVITR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLADEVITR 9 1 Q58WW2;Q58WW2-2;Q58WW2-4;Q58WW2-3 Q58WW2 DCAF6 DDB1- and CUL4-associated factor 6 1 2627310.0 827740.0 909310.0 890260.0 True False 1133777.8468324135 869133.6775139412 679998.9234802327 1.0 0.7665819895336251 0.599763812090734 20.112706554692004 -7.3048349303627935 0.10275244120029119 1.417137573432028 1.1121675001271765e-12 0.9999987470203269 0.00018365098919093296 0.1096489935854829 0.005906832920718 0.030719344765594316 0.048576019985105544 4.9563854071734876e-08 7.3048349303627935 -1.4171375734309157 K(ub)LADEVITR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLADEVITR 9 1 Q58WW2;Q58WW2-2;Q58WW2-4;Q58WW2-3 Q58WW2 DCAF6 DDB1- and CUL4-associated factor 6 1 4416780.0 946170.0 2504400.0 966210.0 True False 786782.2774380686 2490908.300115524 1168240.0437497168 1.0 3.165943580003421 1.484832687835517 19.58560493517962 -6.582311621849076 2.258556804235623 2.472901292367319 1.4892111580346217 0.0 0.9404043489225326 0.6922721215904445 6.645835369457418 0.3491886200750575 1.0501775898941241 2.6163050419505376e-07 6.582311621849076 -0.9836901343326974 K(ub)LADEVITR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLADEVITR 9 1 Q58WW2;Q58WW2-2;Q58WW2-4;Q58WW2-3 Q58WW2 DCAF6 DDB1- and CUL4-associated factor 6 1 6585400.0 2399500.0 2662400.0 1523500.0 True False 3106200.051216241 2514235.0995623088 1246238.6324300852 1.0 0.8094247176957753 0.4012100353749325 21.56671931714453 -6.958681229049751 0.45363752512674477 1.0126855094145977 0.18166772043646978 0.9997181171366436 0.004193633620072889 0.08017561498658654 0.022897657778137428 0.005486632200209337 0.03374873643845346 1.099812802801558e-07 6.958681229049751 -0.8310177889781278 down K(ub)LAEQFPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLAEQFPR 8 1 Q96K17;E9PL10;Q96K17-2 Q96K17 BTF3L4 Transcription factor BTF3 homolog 4;Transcription factor BTF3 1 5527110.0 2433560.0 2637200.0 456350.0 True False 3190420.7266285657 2243740.039725086 409131.2796183047 1.0 0.7032740293460068 0.12823740649737086 21.605315256698972 -7.31151017317139 0.5556619191511553 1.0050083411494226 1.3785998883961897e-21 0.9975503454547573 0.01791140835634147 0.10084537101658522 0.06014013379996373 0.01798522313139579 0.05920979209433936 4.880786680696179e-08 7.31151017317139 -1.0050083411494226 down K(ub)LAEQFPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLAEQFPR 8 1 Q96K17;E9PL10;Q96K17-2 Q96K17 BTF3L4 Transcription factor BTF3 homolog 4;Transcription factor BTF3 1 8658600.0 3012700.0 3874800.0 1771100.0 True False 2917063.4875686076 5422027.8468150655 1307195.7781389044 1.0 1.8587280907397608 0.4481204415706636 21.47608535501301 -6.741948057941501 1.6797733329038524 1.509783243573357 0.44696970225346333 0.6135934033636099 0.36078727226594126 0.314290294214585 1.7420296627464589 0.16987217668459553 0.41592926976177147 1.811556743678991e-07 6.741948057941501 -1.0628135413198936 K(ub)LAQQYYLVYQEPIPTAQLVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLAQQYYLVYQEPIPTAQLVQR 22 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 69170000.0 10829000.0 20807000.0 37534000.0 True False 14196923.868185168 17702676.705050774 33650341.73155132 1.0 1.2469374964193392 2.37025584161655 23.7590750304996 -6.941933789135231 0.6413195004616377 0.9876909457753348 2.6912288142121636 0.9984063945236851 0.02380525572946987 0.08689537173979131 0.05067431004228049 0.023527448054840604 0.09588819968020779 1.1430525869034204e-07 6.941933789135231 1.703537868436829 up K(ub)LAQQYYLVYQEPIPTAQLVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLAQQYYLVYQEPIPTAQLVQR 22 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 526442000.0 54228000.0 89034000.0 383180000.0 True False 52506561.82290647 124585740.50617646 282813662.8464037 1.0 2.372765158883909 5.386253699114301 25.64599439399615 -6.9581833996958835 0.46032105755050023 0.9124432494774387 6.968120668744592 0.9996967790709966 0.031900423090565684 0.08035653493925528 0.023578079380912532 0.040948956744191724 0.24893577061129363 1.1010742349606408e-07 6.9581833996958835 6.055677419267154 K(ub)LAQQYYLVYQEPIPTAQLVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLAQQYYLVYQEPIPTAQLVQR 22 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 919808200.0 79656000.0 303366200.0 536786000.0 True False 120843975.63364471 249228131.3990608 430690011.8183381 1.0 2.0623959952677366 3.5640172342892344 26.84857031213534 -6.966226323005954 0.33634181066853386 0.8300687037195145 4.845972316936959 0.9999362376454505 0.008399261817445847 0.07754724800780148 0.013406013357835152 0.021443159681975493 0.13032665072609848 1.080870532627074e-07 6.966226323005954 4.015903613217445 K(ub)LAQQYYLVYQEPIPTAQLVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLAQQYYLVYQEPIPTAQLVQR 22 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 174816000.0 10829000.0 22897000.0 141090000.0 True False 14832773.942721393 21885334.829746455 107767447.83976142 1.0 1.4754714737957584 7.265495197049376 23.82228509202249 -6.92318366647582 0.8007674672274266 0.8863051933262357 8.271142741602572 0.9950204473935529 0.20098136697751737 0.09633443725579592 0.09617360481891346 0.17615256100041723 0.5448436893653519 1.1934832644718367e-07 6.92318366647582 7.384837548276336 up K(ub)LAQQYYLVYQEPIPTAQLVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLAQQYYLVYQEPIPTAQLVQR 22 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 379636900.0 54228000.0 107120000.0 218288900.0 True False 45092984.70772864 106542923.2983449 263932099.7361622 1.0 2.3627383281214502 5.853063429862649 25.426399669430428 -6.954940961817391 0.5016803454231605 0.9311062398520356 7.435666293654346 0.9995341355844257 0.044111741480404774 0.08156033888157171 0.02820556900157337 0.051569672761034475 0.28793775634396795 1.1093256072230607e-07 6.954940961817391 6.50456005380231 K(ub)LAQQYYLVYQEPIPTAQLVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLAQQYYLVYQEPIPTAQLVQR 22 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 510352100.0 79656000.0 285646100.0 145050000.0 True False 103116262.25450331 269749643.43189764 118652388.338683 1.0 2.615975768847431 1.1506661097338329 26.61969663422779 -6.622778106299517 2.1067183602420885 2.0701254477356437 1.156350347634315 0.09226415014932243 0.6944283059315054 0.5778920576250828 4.877644557928664 0.27049921029319557 0.7697146486552845 2.3835369767688261e-07 6.622778106299517 -0.9137751001013286 K(ub)LDEAVAEAHLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLDEAVAEAHLGK 13 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 9204700.0 1259800.0 1435500.0 6509400.0 True False 1630835.9343705848 1355613.163094086 5324755.992084269 1.0 0.8312382223888635 3.2650470104703326 20.63718022042631 -6.890273224883621 1.0207378946912762 0.8700842990804539 3.475522455261071 0.9810735494620159 0.15266136448462736 0.11892281291445929 0.22054176521128563 0.11391322504977121 0.2842756837450398 1.287439338458373e-07 6.890273224883621 2.605438156180617 up K(ub)LDELYGTWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLDELYGTWR 10 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 21339200.0 1819400.0 2241200.0 17278600.0 True False 2385251.019094661 1906821.6961291737 15490776.220034689 1.0 0.7994218138319553 6.494400839167998 21.185709669914168 -6.898734690100654 0.9692182863927293 0.7549333348563175 7.077087749618536 0.985926638508213 0.31302420101880307 0.11234314372978398 0.18271296313483248 0.2427879030549908 0.6277860816656529 1.26259861879245e-07 6.898734690100654 6.322154414762219 up K(ub)LDELYGTWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLDELYGTWR 10 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 28780100.0 2387400.0 6340400.0 20052300.0 True False 2311613.2937966906 8872154.784749204 14800001.073894633 1.0 3.8380791495523914 6.402455425226635 21.140468641131523 -7.417038619218137 0.2524965636234678 2.7684326980233846e-16 9.169223530933532 0.9998882785371865 0.023322202696260813 0.12750256051539982 0.022659715674860664 0.1875610829016967 0.5045827244272741 3.827907025091173e-08 7.417038619218137 9.169223530933532 K(ub)LDELYGTWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLDELYGTWR 10 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 41041600.0 3017400.0 6138200.0 31886000.0 True False 4577616.401488388 5042790.252024502 25583718.123869758 1.0 1.1016192292532123 5.588873308727081 22.12616514124846 -6.91178034058941 0.8835084929712131 0.868765596794215 6.191443806305081 0.9915765770670184 0.1963768463241018 0.10325287201481871 0.13246298346914312 0.16220507205545676 0.4534888997408749 1.225235747803744e-07 6.91178034058941 5.322678209510866 up K(ub)LDELYGTWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLDELYGTWR 10 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 20182900.0 2387400.0 5849600.0 11945900.0 True False 1985228.8797527363 5818087.043745307 14443732.458399061 1.0 2.930688296490005 7.275600614976976 20.9208739165658 -6.957673737622409 0.46706689918698047 0.8819064968824066 9.501624931786896 0.999673948350987 0.04738918063208432 0.08054284194005704 0.024282967234167816 0.05974967718096643 0.3586903819216655 1.1023671484354282e-07 6.957673737622409 8.61971843490449 K(ub)LDELYGTWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLDELYGTWR 10 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 38468700.0 3017400.0 6883300.0 28568000.0 True False 3906083.781846162 6500238.304093015 23368917.13243362 1.0 1.6641318177309445 5.982697360728036 21.89729146334091 -6.934157212351252 0.711839610373922 0.9433603044496589 6.971069044531993 0.9972940978728669 0.11490999516759438 0.09053593569805213 0.06752130430229746 0.1074098887164864 0.38221803602179355 1.1637046980866549e-07 6.934157212351252 6.027708740082335 K(ub)LDNTK(ub)FR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLDNTKFR 8 2 J3KTL2;Q07955;Q07955-3;Q07955-2;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 2 18017570.0 7906700.0 9871400.0 239470.0 True False 6574771.376200447 9818220.808880512 289542.0698158211 1.0 1.4933174474204227 0.044038347989393836 22.648509297925855 -6.814833156394705 1.3940478150892925 1.2673478603179498 0.015750661112780655 0.8721270537473935 0.2151390624252269 0.20025500829221884 0.7660347461042473 0.12131659545850645 0.28007696993742043 1.5316757749988924e-07 6.814833156394705 -1.251597199205169 down K(ub)LDPELHLDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLDPELHLDIK 11 1 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 1 14706500.0 3391900.0 6676900.0 4637700.0 True False 4446813.747206321 5680732.54635235 4157835.2919597 1.0 1.2774838051000517 0.9350144908974051 22.08434054864615 -6.691133373824907 1.8620580406445857 1.1737768572338947 0.93617116358034 0.37586302971355545 0.11732892495655525 0.4142497328712167 2.7855479412237627 0.0503871208478603 0.13104040896661032 2.036416588802082e-07 6.691133373824907 -0.23760569365355466 K(ub)LDPELHLDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLDPELHLDIK 11 1 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 1 14121400.0 4200800.0 3711500.0 6209100.0 True False 4067447.9034016617 5193521.305216808 4582750.440992759 1.0 1.2768501105750847 1.1266894007812964 21.955692437044867 -10.17707193637503 4.074472929274556 0.9999123104844959 1.2017697557121554 0.7065163197605052 0.06130285318818663 8398950.50339558 10489304.725659234 5273.883825772542 0.02098559677722068 6.651629697316403e-11 10.17707193637503 0.20185744522765947 K(ub)LDPELHLDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLDPELHLDIK 11 1 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 1 102042000.0 10958000.0 18922000.0 72162000.0 True False 16624087.137108048 15545221.261739217 57899149.07027189 1.0 0.9351022485342607 3.4828468229711236 23.986771785641864 -6.901056985902715 0.9545790690839308 0.8971243431813334 3.756074252345236 0.9870843868842453 0.1347872132635873 0.11063084704885892 0.17307181984429737 0.10568895586193405 0.27646649333061063 1.2558651646735034e-07 6.901056985902715 2.858949909163903 up K(ub)LDPELHLDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLDPELHLDIK 11 1 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 1 14225800.0 3391900.0 6374400.0 4459500.0 True False 4645977.092650907 6092757.930678062 3406257.9462854676 1.0 1.3114050735023424 0.7331628801342025 22.14755061016904 -6.760446320572133 1.6107673746359814 1.1807887488167579 0.7310057158808455 0.692723672682846 0.13098702237637125 0.28220669001022364 1.4432034522891934 0.06415775986338029 0.15411472976657983 1.7360158236848992e-07 6.760446320572133 -0.4497830329359124 K(ub)LDPELHLDIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLDPELHLDIK 11 1 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 1 16522900.0 4200800.0 8585000.0 3737100.0 True False 3493151.3269939204 8538750.90101093 4518510.33160189 1.0 2.44442627922423 1.293534092463826 21.736097712479143 -6.589384748506675 2.231065242588303 1.9779477233840619 1.2968199931033297 0.0 0.6260042281218062 0.6712007636539407 6.297635353085362 0.2343115135738942 0.6979199119958207 2.5740397631260406e-07 6.589384748506675 -0.6811277302807321 K(ub)LDPELHLDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLDPELHLDIK 11 1 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 1 105123000.0 10958000.0 19068000.0 75097000.0 True False 14185347.014472824 18006849.03788089 61430116.56029015 1.0 1.2693978525522935 4.330533225420225 23.757898107734313 -6.924196046729413 0.792983201603603 0.9421141727856266 4.875180984306537 0.9952693537712379 0.10389446964962118 0.09576547834762911 0.09327804837232995 0.0915659759006956 0.28632590949788295 1.1907043857322948e-07 6.924196046729413 3.93306681152091 up K(ub)LDPGSEETQTLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLDPGSEETQTLVR 14 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 7739200.0 1996300.0 2189600.0 3553300.0 True False 2617168.632196702 1862920.2149939502 3185638.601660391 1.0 0.711807482359408 1.217208001987456 21.319575453968415 -6.752031619933919 1.6422264090911944 0.8309533030574507 1.2183755641944722 0.6576820227119115 0.12111504895538429 0.29652769817814134 1.5740093201305583 0.05824344623469217 0.14110457534167706 1.7699800856443246e-07 6.752031619933919 0.3874222611370215 K(ub)LDPGSEETQTLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLDPGSEETQTLVR 14 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 6638800.0 1164300.0 1621900.0 3852600.0 True False 1127339.9338055993 2269533.1280967672 2843488.4844774115 1.0 2.013175493957202 2.5222990858476484 20.104491175223234 -9.434128468993007 0.19622781520125027 3.028074792187772e-17 3.038261455033063 0.9995163953018005 0.013914374355451085 0.8648844660146855 0.07666931846820539 0.813184928001393 0.2994148249976037 3.6802009322546995e-10 9.434128468993007 3.038261455033063 K(ub)LDPGSEETQTLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLDPGSEETQTLVR 14 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 20892800.0 3664900.0 6583900.0 10644000.0 True False 5559921.240079149 5408951.604754514 8540208.734569067 1.0 0.9728468032539098 1.5360305237790548 22.40663301569885 -6.895574121943545 0.9888181344768163 0.9736565209585453 1.5901094257169428 0.9842324101099885 0.03256311155699687 0.1147382914258756 0.19636043032436487 0.024889446264196192 0.06343384578652761 1.2718206672796712e-07 6.895574121943545 0.6164529047583975 K(ub)LDPGSEETQTLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLDPGSEETQTLVR 14 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 7264300.0 1996300.0 1812500.0 3455500.0 True False 2734386.0579790147 1732417.7568640183 2639382.068256399 1.0 0.6335673603252822 0.9652558242661488 21.382785515491307 -10.347453134754856 8.174089342583269 1.0000009296713457 0.7994115934666495 0.32778945814797433 0.13541124837044347 2.2941679425249147e-06 1.8320499274801107e-07 0.13111198600020704 0.043703792485656964 4.4931080772941995e-11 10.347453134754856 -0.2005893362046962 K(ub)LDPGSEETQTLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLDPGSEETQTLVR 14 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 6137900.0 1164300.0 3335400.0 1638200.0 True False 968167.0372355331 3317431.5381749375 1980740.0458190124 1.0 3.4265074213303146 2.045866022742048 19.88489645065751 -10.016634784995434 6.044389328535816 0.9999980241751966 2.73618672203631 0.678299526823018 0.563644490717755 1.5007544078627524e-05 2.441946890562829e-06 0.5457470571934698 0.18191547714421843 9.624212754018187e-11 10.016634784995434 1.7361886978611132 K(ub)LDPGSEETQTLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLDPGSEETQTLVR 14 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 20468500.0 3664900.0 6052600.0 10751000.0 True False 4744285.2959793275 5715767.489336993 8794428.314575547 1.0 1.2047689236102588 1.8536887572989387 22.1777593377913 -6.9502122685279675 0.5565089758575889 0.9913527904500498 2.0979325071173185 0.9992178318434407 0.010177299931979699 0.083400636108553 0.03561056982366329 0.010956064773608535 0.05390283920641988 1.121470183438519e-07 6.9502122685279675 1.1065797166672686 K(ub)LDVSIEMPEELDISQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLDVSIEMPEELDISQLR 18 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 22498200.0 2520400.0 13445000.0 6532800.0 True False 2440391.281597209 18813658.61474877 4821663.700200915 1.0 7.709279555545469 1.9757748425675368 21.218681051031492 -6.60785109127504 2.1612536318326376 5.488921845257535 1.9957447689468242 0.043807086608752877 2.8941686550569092 0.618681118977606 5.472829791664718 1.106930499358889 3.2149729479248244 2.4668850254719134e-07 6.60785109127504 -3.4931770763107104 K(ub)LDVSIEMPEELDISQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLDVSIEMPEELDISQLR 18 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 167203000.0 64037000.0 71822000.0 31344000.0 True False 97148810.73179308 59004802.95215272 25148844.661436748 1.0 0.6073651597758851 0.25886930032388444 26.533692999066457 -7.670209516783833 0.29532257800033984 1.103000517045338 1.5306835291100663e-14 0.9995660707218846 0.006306451472788347 0.1259382867449248 0.03952548977809773 0.033266825418219216 0.07622344931491679 2.136930920727719e-08 7.670209516783833 -1.1030005170453228 down K(ub)LDVSIEMPEELDISQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLDVSIEMPEELDISQLR 18 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 15937000.0 2520400.0 8212600.0 5204000.0 True False 2095824.272651753 8168357.093726527 6292132.339422611 1.0 3.897443693307106 3.0022232405303027 20.99908632646577 -10.239560875577318 5.8688917661107665 0.9999156350986131 3.4498334669187067 0.9089674972814332 0.36547221943448716 0.0004034858135122206 5.2280161419508545e-05 0.3538786682107665 0.11795565161425879 5.760220711976233e-11 10.239560875577318 2.449917831820094 K(ub)LDVSIEMPEELDISQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 KLDVSIEMPEELDISQLR 18 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 196296000.0 87396900.0 71262200.0 37636900.0 True False 113137009.9004544 67296395.92549174 30787370.387205664 1.0 0.5948221186391939 0.2721246603060703 26.75349570669057 -7.833710064658229 0.26607217941617767 1.1429400932438416 3.682113276337318e-13 0.9996141609151593 0.005849405564683966 0.1180688675646569 0.0418909656680435 0.04912599009323367 0.08647297893663188 1.4665265685242557e-08 7.833710064658229 -1.1429400932434735 down K(ub)LDYGQHVVAGTPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLDYGQHVVAGTPGR 15 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 8887300.0 2316500.0 3171300.0 3399500.0 True False 3036953.933017911 2698154.401630578 3047752.3503066176 1.0 0.8884410040916697 1.003555673720074 21.53419359402623 -11.010417890693645 8.3500848842166 1.065977734520523 0.9459983389017643 0.2268567046377985 0.0469953670831084 0.049970530145578285 6.234523130680589e-05 0.03939218339249318 0.015167689505148579 9.762973473368341e-12 11.010417890693645 -0.1199793956187587 K(ub)LDYGQHVVAGTPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLDYGQHVVAGTPGR 15 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 13590600.0 2048000.0 2696300.0 8846300.0 True False 1982987.3610185247 3772946.6510187495 6529188.646688619 1.0 1.9026579418442915 3.2926022500390633 20.919244051603993 -6.964817926261792 0.3611628643509833 0.8818083841993826 4.361169822060849 0.9999093437408488 0.008978369878518553 0.07802279576887745 0.015078088504216816 0.018604903621044118 0.11863671174437218 1.084381435109293e-07 6.964817926261792 3.4793614378614666 K(ub)LDYGQHVVAGTPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLDYGQHVVAGTPGR 15 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 61928200.0 6475500.0 7157700.0 48295000.0 True False 9823806.922462415 5880352.511634648 38749472.08154951 1.0 0.5985818489763937 3.9444456092625084 23.227850775518494 -6.876937273744919 1.096782976782869 0.7600123099746372 4.1680260061985654 0.9711278113602292 0.25346176794325703 0.13037547163440982 0.289000132772018 0.17848659065460043 0.42844578207436823 1.327586190528598e-07 6.876937273744919 3.4080136962239282 up K(ub)LDYGQHVVAGTPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLDYGQHVVAGTPGR 15 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 10509100.0 2316500.0 2669500.0 5523100.0 True False 3172972.6510586506 2551552.6631439975 4218657.531815058 1.0 0.8041521134109623 1.3295600043724038 21.597403655549122 -6.8057982115175575 1.4324647300050226 0.8927227987319429 1.3378645979699326 0.8484737215588781 0.08439233243474932 0.21259482169435598 0.8605811477858258 0.04633836748534079 0.10739172671303214 1.5638741047397257e-07 6.8057982115175575 0.4451417992379897 K(ub)LDYGQHVVAGTPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLDYGQHVVAGTPGR 15 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 90584300.0 6475500.0 5454800.0 78654000.0 True False 8382662.401188059 5151235.584845428 64339779.058192186 1.0 0.6145106814888971 7.675339406376837 22.998977097610943 -6.893995023744419 0.9984791625824982 0.6561424692551225 8.332314657795726 0.9833336040816526 0.4184683807823603 0.11596047728052475 0.20340598282270772 0.3175507472462997 0.8039127160652564 1.2764534346525678e-07 6.893995023744419 7.676172188540603 up K(ub)LEDGPK(ub)FLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLEDGPKFLK 10 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 3504310.0 835410.0 1025300.0 1643600.0 True False 808890.3668303138 1434707.6368688657 1213091.8530569153 1.0 1.773673782877221 1.499698726553624 19.62558465428816 -10.213954299924419 4.948692269143815 0.9999179672256121 1.6366862547161825 0.8780574436501544 0.11184984837672479 0.0001012536704015321 1.6082812463251285e-05 0.10831200750260943 0.036099383336162555 6.11006316686659e-11 10.213954299924419 0.6367682874905704 K(ub)LEDGPK(ub)FLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLEDGPKFLK 10 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 2711120.0 835410.0 1035300.0 840410.0 True False 694680.4299381048 1029722.6334090388 1016135.8453831972 1.0 1.4822968793014448 1.4627385508380215 19.405989929722438 -10.159015403572575 5.128220270179321 0.9999770036572129 1.4725177150702013 0.9987166914748763 0.007984654161158053 2.0994627301682505e-06 3.443007068121652e-07 0.007731483832364905 0.00257703604904776 6.934012120008628e-11 10.159015403572575 0.4725407114129885 K(ub)LEELELDEQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLEELELDEQQR 12 1 Q02750;Q02750-2 Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 1 6545800.0 1970900.0 2715900.0 1859000.0 True False 2583868.986222752 2310698.3064952833 1666648.512787174 1.0 0.8942784323880116 0.6450205183288246 21.30110149008413 -6.9567052744601146 0.4796200796609834 1.0060043369239506 0.5229091053253515 0.9996278039348842 0.0028710180055852305 0.08089978838125948 0.025644899130641313 0.003511760267666427 0.020561941504311287 1.1048281357700666e-07 6.9567052744601146 -0.48309523159859913 K(ub)LEELELDEQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLEELELDEQQR 12 1 Q02750;Q02750-2 Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 1 20221600.0 3053000.0 4803600.0 12365000.0 True False 4631624.204197009 3946360.0493018995 9921052.330227965 1.0 0.8520466849892208 2.142024458987383 22.143086771542663 -6.878356368978666 1.0888730113980982 0.9101397245200935 2.2306296945708306 0.9723375923941324 0.09586728248454641 0.12909843634097276 0.2811397088706335 0.06791606326293007 0.16358116087049498 1.3232552661371647e-07 6.878356368978666 1.320489970050737 up K(ub)LEELELDEQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLEELELDEQQR 12 1 Q02750;Q02750-2 Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 1 6828700.0 1970900.0 3080400.0 1777400.0 True False 2699594.9915698245 2944297.742479407 1357614.7267020475 1.0 1.0906442454048588 0.5028957050748526 21.36431155160702 -6.86754055607157 1.1471027919672168 1.050571255603466 0.4700566349560581 0.962162248181874 0.050257189750342976 0.1392307567640576 0.34396141360773785 0.034051591050655444 0.08028745402811888 1.3566238376873947e-07 6.86754055607157 -0.580514620647408 K(ub)LELSDNIISGGLEVLAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLELSDNIISGGLEVLAEK 19 1 Q9BTT0;Q9BTT0-3;Q5TB19;E9PLC4 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 31917200.0 6132600.0 6688600.0 19096000.0 True False 9303602.553114513 5494967.07172967 15321667.229925873 1.0 0.5906278820874772 1.6468531563396083 23.14935803598718 -6.80161008375307 1.4493339920874073 0.7745915110135942 1.6620194835579936 0.8368315721158577 0.17564170195000667 0.21846506311184236 0.9058094560375849 0.09533084203197653 0.221490125365681 1.579028309318973e-07 6.80161008375307 0.8874279725443993 K(ub)LELSDNIISGGLEVLAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLELSDNIISGGLEVLAEK 19 1 Q9BTT0;Q9BTT0-3;Q5TB19;E9PLC4 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 33003000.0 6132600.0 7811400.0 19059000.0 True False 7938771.591618548 7376688.723227538 15590457.56185427 1.0 0.9291977528381802 1.9638375259862721 22.92048435807963 -6.890505242703685 1.0193672408015548 0.945079209496067 2.053719365339218 0.9812204708264777 0.06467276612603082 0.11873502993850749 0.2194502166726917 0.048307878763746856 0.1206559924222635 1.2867517195633693e-07 6.890505242703685 1.1086401558431511 K(ub)LEPLSQDEDQHADLTQSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLEPLSQDEDQHADLTQSR 19 1 P49366;P49366-3;A0A087WZK0;P49366-2;Q5J8M5;M0R253;M0QX43;B4E3M2;A0A3B3IU31;M0R264;M0R0J4;M0QYZ7 P49366 DHPS Deoxyhypusine synthase 1 27992100.0 3464600.0 4935500.0 19592000.0 True False 5256051.496187668 4054721.463762493 15719632.612521356 1.0 0.7714386867601036 2.9907683788720787 22.325547979864673 -6.881493937895908 1.0713954814672186 0.8553252664532942 3.152650751012694 0.9748721784989842 0.15799557361038752 0.12631662528093107 0.2643394114112379 0.11343729771117933 0.27540040580377056 1.3137298325437597e-07 6.881493937895908 2.2973254845594 up K(ub)LEPLSQDEDQHADLTQSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLEPLSQDEDQHADLTQSR 19 1 P49366;P49366-3;A0A087WZK0;P49366-2;Q5J8M5;M0R253;M0QX43;B4E3M2;A0A3B3IU31;M0R264;M0R0J4;M0QYZ7 P49366 DHPS Deoxyhypusine synthase 1 33282400.0 3464600.0 9514800.0 20303000.0 True False 4484992.997476043 8985293.015818605 16608062.326372167 1.0 2.003412941976751 3.7030297116892834 22.096674301957123 -6.9631591473977 0.3883521273210514 0.8936800159561644 4.873670728807182 0.9998700262378658 0.012718985578670227 0.07859131098979615 0.017097926857282997 0.021965681922668786 0.14306983325934358 1.0885311275424116e-07 6.9631591473977 3.979990712851018 K(ub)LEQLYNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLEQLYNR 8 1 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 10732500.0 2898700.0 3848500.0 3985300.0 True False 2806682.355168158 5385226.119662378 2941430.3735627434 1.0 1.9187159208615647 1.0480097144397063 21.42043436614411 -10.344172744535106 4.80094936132897 0.9996566952634486 1.4833628176509548 0.29123530047278 0.3554643202690988 0.0013070935062952226 0.00017855307496299992 0.34441625503448653 0.11472561604760692 4.527174716412317e-11 10.344172744535106 0.4837061223875062 K(ub)LEQLYNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLEQLYNR 8 1 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 12981500.0 4255700.0 4063700.0 4662100.0 True False 6456208.033344649 3338500.9851669814 3740633.891528982 1.0 0.5170993511864062 0.5793855886008588 22.622255635523388 -10.332855736045873 5.733276606318688 1.0000676056198081 0.54824246989395 0.985943196519121 0.025428249943884373 2.1977001580702603e-05 2.5573340658319277e-06 0.024624461418671025 0.008206932379654171 4.6466960355188975e-11 10.332855736045873 -0.45182513572585814 K(ub)LEQLYNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLEQLYNR 8 1 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 12331600.0 2898700.0 7456500.0 1976400.0 True False 2410397.484183317 7416330.354500632 2389656.10215889 1.0 3.076808038161975 0.9913950366441515 21.200839641578387 -6.647084995673692 2.01865382326202 2.3506944804311005 1.0000820396528431 0.1824841729705302 0.8870329583239029 0.5156642158556819 4.024225665720442 0.3567601913504122 0.9825651005831887 2.253798078680433e-07 6.647084995673692 -1.3506124407782574 K(ub)LFETQESGDLNEELVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLFETQESGDLNEELVK 17 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 121858810.0 22900000.0 40011810.0 58947000.0 True False 30022121.763915423 34042203.912813775 52847729.8995512 1.0 1.1339039985418427 1.7602929704678842 24.839522604864626 -6.941301636722252 0.6473476459770795 0.9930965211119193 1.9358770560707743 0.9983293914118565 0.01354468748286774 0.08717792423197858 0.05194425611037186 0.013318542506666219 0.05361045234479592 1.1447176082819374e-07 6.941301636722252 0.942780534958855 K(ub)LFETQESGDLNEELVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLFETQESGDLNEELVK 17 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 288654300.0 63481000.0 80718900.0 144454400.0 True False 61465830.402742535 112950377.71350256 106617459.10089149 1.0 1.8376124909306168 1.7345809598975879 25.87328128591251 -10.346529226228704 5.594404280009319 0.9998263414008262 1.7860967254141091 0.9872799181065294 0.04206244640813246 9.112554487291235e-05 1.0644177820060993e-05 0.04073557920073064 0.013575596203283118 4.502676791094519e-11 10.346529226228704 0.786270384013283 K(ub)LFETQESGDLNEELVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLFETQESGDLNEELVK 17 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 477630400.0 157085100.0 228154000.0 92391300.0 True False 238309581.15909213 187438136.12466148 74130119.05845469 1.0 0.7865321033799745 0.3110664653007235 27.82826171487734 -6.957886161540468 0.46426959488278197 1.0132836051728307 0.06501028091483826 0.9996835766451825 0.00512223413750623 0.08046509585882414 0.023988423169066724 0.006505509908388829 0.03926126662214368 1.1018280858891396e-07 6.957886161540468 -0.9482733242579924 down K(ub)LFETQESGDLNEELVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLFETQESGDLNEELVK 17 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 120142000.0 22900000.0 36147000.0 61095000.0 True False 31366748.84923074 34549906.017855845 46665619.291021556 1.0 1.1014818967667148 1.4877416692219925 24.902732666387518 -6.94601735752646 0.6009879709966652 0.995658629586116 1.6133710074500536 0.9988504444040013 0.007124435973495707 0.0851256554190811 0.042893952862546485 0.007305006232381488 0.032470703723419675 1.1323551052889288e-07 6.94601735752646 0.6177123778639376 K(ub)LFETQESGDLNEELVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLFETQESGDLNEELVK 17 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 217896800.0 63481000.0 116869600.0 37546200.0 True False 52787264.18513165 116240000.26800078 45396936.825985685 1.0 2.202046309131163 0.8599979090936188 25.653686561346785 -6.67053927470102 1.9350378901690106 1.7668740418767992 0.8653541174114363 0.28166494208080006 0.5105337099672305 0.4598509398252083 3.319962567839784 0.2123433344431207 0.5670169914136592 2.1353089741908774e-07 6.67053927470102 -0.9015199244653629 K(ub)LFETQESGDLNEELVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLFETQESGDLNEELVK 17 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 448190100.0 157085100.0 228148000.0 62957000.0 True False 203349758.56024504 215451363.24178964 51499471.99337106 1.0 1.0595112812880934 0.25325563383009214 27.59938803696979 -6.889132944936306 1.0275183334718847 1.044225968880767 0.18508193778161458 0.9803367705328057 0.051441915187101485 0.11984864918305417 0.22598950781819224 0.03818962542617384 0.09491321121774161 1.2908240698986976e-07 6.889132944936306 -0.8591440310991523 down K(ub)LFETQESGDLNEELVK(ub)AAANGDVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLFETQESGDLNEELVKAAANGDVAK 26 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 103037200.0 26536000.0 24660000.0 51841200.0 True False 25693629.20507201 34506866.60020113 38262434.51733652 1.0 1.3430125547771723 1.4891798356685002 24.614907348392013 -12.151383140026901 0.13874555038663255 4.871202954388855e-14 1.693079745662986 0.9996521909297478 0.0038236489016416323 5.863951904447983 0.09790841827766479 1.8449570559753936 0.16013649746134656 7.056947068596835e-13 12.151383140026901 1.6930797456629374 K(ub)LFETQESGDLNEELVK(ub)AAANGDVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLFETQESGDLNEELVKAAANGDVAK 26 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 134785000.0 25380000.0 74034000.0 35371000.0 True False 38503315.52653791 60822054.26971777 28379906.346339945 1.0 1.5796575811191365 0.7370769493027026 25.198479346064353 -6.721584043163804 1.7536883113601 1.3520584955092838 0.7382780529858423 0.5199622475513788 0.24387551625663215 0.352242557896944 2.1179659608402375 0.11038465995728891 0.2765842104595047 1.898523410876241e-07 6.721584043163804 -0.6137804425234415 K(ub)LFETQESGDLNEELVK(ub)AAANGDVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLFETQESGDLNEELVKAAANGDVAK 26 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 71169000.0 26536000.0 19626000.0 25007000.0 True False 22065859.74412271 19520270.842544034 30235848.08069589 1.0 0.8846367677898116 1.3702547025727958 24.39531262382629 -6.8440388355177735 1.2635210247111304 0.9386247706361492 1.387546234645103 0.9311787216186066 0.05434487751657103 0.16413086939305563 0.5072486095821652 0.03370172494138618 0.07774659315935654 1.4320598357724134e-07 6.8440388355177735 0.44892146400895383 K(ub)LFETQESGDLNEELVK(ub)AAANGDVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLFETQESGDLNEELVKAAANGDVAK 26 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 149091000.0 25380000.0 102373000.0 21338000.0 True False 32854910.314593945 96675852.5569006 17454702.946368966 1.0 2.942508490548452 0.5312661875876646 24.969605668156802 -6.6922528918276125 1.8582662082249282 2.2151896424172777 0.5392963750363702 0.3811906787202778 0.8211610809655161 0.4117644428276428 2.758469562441892 0.35327371573425304 0.9173943282093564 2.0311739038816867e-07 6.6922528918276125 -1.6758932673809075 K(ub)LFIGGLSFETTDESLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLFIGGLSFETTDESLR 17 1 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;F8W646;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 1 30042400.0 7418200.0 8026200.0 14598000.0 True False 9603006.13458317 7579534.914403173 11941313.788128905 1.0 0.7892877301314118 1.2434974653535649 23.19505466855018 -6.780562731851001 1.5337242033901228 0.8807772725382593 1.2471565110352212 0.769367481894628 0.08912876163619765 0.24969749632611205 1.1602043341729773 0.04576957245852189 0.10794419473289979 1.6574379102339512e-07 6.780562731851001 0.36637923849696186 K(ub)LFNLSK(ub)EDDVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLFNLSKEDDVR 12 2 P62753;A2A3R5 P62753 RPS6 40S ribosomal protein S6 2 6050200.0 2124700.0 2262000.0 1663500.0 True False 2057252.5615019796 3165228.396174166 1227779.4460697128 1.0 1.5385706429079686 0.5968054039866273 20.972287488544026 -6.751597511598539 1.6439500069275368 1.3160724976366716 0.5947038596837613 0.6558313433593209 0.22633056992268732 0.2972559764394461 1.581081636712319 0.108735870375402 0.2635382503267483 1.7717501916105247e-07 6.751597511598539 -0.7213686379529103 K(ub)LFTAESLIGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLFTAESLIGLK 12 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 3616540.0 1197300.0 1656400.0 762840.0 True False 1569671.8946696916 1409271.5765966314 683908.6344779821 1.0 0.8978128367987289 0.43570165000749916 20.582031596338023 -6.942068293388976 0.6400346473157049 1.0050589675224189 0.30311843356095053 0.9984224281036613 0.009750833364335753 0.08683565986018879 0.05040735077769965 0.009647630779996638 0.039424795055593945 1.1426986297706451e-07 6.942068293388976 -0.7019405339614684 down K(ub)LFTAESLIGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLFTAESLIGLK 12 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 8001600.0 3700400.0 3070500.0 1230700.0 True False 3077046.5555152125 3053958.6070534727 1488033.6798861285 1.0 0.9924967178607169 0.48359153917220343 21.553114841043346 -6.910109035656345 0.8949930363514598 1.0157024290265035 0.4176707172059736 0.9909626229838703 0.022976112710920402 0.10434593863547971 0.13837689402869152 0.01882099746869556 0.05199372829044888 1.229959933535711e-07 6.910109035656345 -0.5980317118205299 down K(ub)LGEMWNNTAADDK(ub)QPYEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLGEMWNNTAADDKQPYEK 19 2 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 2 13356500.0 3201200.0 2008100.0 8147200.0 True False 3099579.6582482914 2809944.802103159 6013203.909239056 1.0 0.906556730886272 1.9400062499562865 21.56364115060491 -6.884823009614622 1.052572867219194 0.9373860232085508 2.0203598648122223 0.9773705659013455 0.07020752303928142 0.12344198028311036 0.24721654024411016 0.05113882182306682 0.1253259122509135 1.3036979733095713e-07 6.884823009614622 1.0829738416036716 K(ub)LGEMWNNTAADDKQPYEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLGEMWNNTAADDKQPYEK 19 2 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 1 5450200.0 1215500.0 1601800.0 2632900.0 True False 1593532.2709187432 1362817.6837674985 2360472.764560167 1.0 0.855218126823232 1.4812833148331839 20.603796805021688 -6.845829809129725 1.255024327578441 0.9229330278626544 1.5043716665496032 0.9340205328640755 0.06874046666169986 0.1621012886941228 0.49342902067895894 0.04290132189192274 0.09904849743220452 1.426166368703513e-07 6.845829809129725 0.5814386386869488 K(ub)LGEMWNNTAADDKQPYEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLGEMWNNTAADDKQPYEK 19 2 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 1 22635600.0 7756200.0 11365300.0 3514100.0 True False 10040553.797559243 10732811.064098371 2874569.857710898 1.0 1.0689461239386426 0.28629594698348976 23.259335509093667 -6.885427203440079 1.0490341006554744 1.0467770117751856 0.22471057583004697 0.9778071865584137 0.05270878068179606 0.12293267856082599 0.24413865288945463 0.038494905932446095 0.09451898609032988 1.3018855196981685e-07 6.885427203440079 -0.8220664359451386 down K(ub)LGGSQEDQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLGGSQEDQIK 11 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 13484200.0 4106100.0 4784100.0 4594000.0 True False 5383136.863528969 4070330.928275743 4118656.948759705 1.0 0.756126219983825 0.7651035173680646 22.360015674938705 -9.938772318317568 5.209272487159074 1.0000007093703083 0.7606148686737191 0.9989463378439261 0.003664966317871661 3.019601925063166e-08 6.146322984389299e-09 0.003548598871084222 0.0011828627916754008 1.1514038616420084e-10 9.938772318317568 -0.2393858406965892 K(ub)LGGSQEDQIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLGGSQEDQIK 11 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 14577200.0 4440100.0 5043500.0 5093600.0 True False 4299151.455887861 7057395.851505039 3759433.3552754372 1.0 1.641578791517022 0.8744593889863411 22.035620505607103 -6.684855199234229 1.8849383061700993 1.4041661679189883 0.8772833246384097 0.34629525689446083 0.27163493982461456 0.42785544029887473 2.943186449285221 0.11546720438430881 0.3026223520802388 2.0660689015886152e-07 6.684855199234229 -0.5268828432805785 K(ub)LGGSQEDQIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLGGSQEDQIK 11 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 44557600.0 7801400.0 9678400.0 27077800.0 True False 11835294.158736503 7951213.902315661 21725860.96137864 1.0 0.6718222458751719 1.8356840708805857 23.496592228000708 -6.831396343378526 1.3215793854158835 0.824801180679778 1.8679222173746732 0.9086473156207086 0.1480917599451105 0.17909915444624472 0.6112671259290146 0.0879671671157318 0.2024412169178433 1.474360396654941e-07 6.831396343378526 1.0431210366948953 K(ub)LGGSQEDQIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLGGSQEDQIK 11 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 11570600.0 4106100.0 4190700.0 3273800.0 True False 5624236.133180201 4005541.0172082987 2500595.8660274385 1.0 0.7121928955965406 0.4446107536764263 22.423225736461596 -6.97287635192365 0.20489245913263607 1.1496079416834941 8.98395735428453e-07 0.999994079168493 0.0005518046909162905 0.0755499893361801 0.006651124688336775 0.008344714665846836 0.028033253402730933 1.0644460337481209e-07 6.97287635192365 -1.1496070432877588 down K(ub)LGGSQEDQIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLGGSQEDQIK 11 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 15470600.0 4440100.0 7781600.0 3248900.0 True False 3692139.8797814017 7739678.976273337 3928229.96878365 1.0 2.0962583293923243 1.0639439719754675 21.81602578104138 -6.632035421681019 2.072981565792985 1.7211770854401895 1.0681302836677635 0.12478185682872256 0.46999959805319114 0.5538229456870264 4.53797058374724 0.1852631470794137 0.5206247128301994 2.3332677498548523e-07 6.632035421681019 -0.653046801772426 K(ub)LGGSQEDQIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLGGSQEDQIK 11 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 45767600.0 7801400.0 7620200.0 30346000.0 True False 10099066.088584429 7196129.171305841 24823339.376254223 1.0 0.7125539241138397 2.4579836549751377 23.267718550093157 -6.864616370526102 1.162106245176145 0.841665234044536 2.55030538559898 0.9590133897040427 0.15469653674871828 0.1421262955486895 0.36212648236573125 0.10360774813042237 0.24326610150815708 1.3657890593263774e-07 6.864616370526102 1.708640151554444 up K(ub)LGQSIESSYSSIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLGQSIESSYSSIQK 15 1 Q9UJX5-2;Q9UJX5;Q9UJX5-3 Q9UJX5-2 ANAPC4 Anaphase-promoting complex subunit 4 1 6483600.0 2136400.0 2337000.0 2010200.0 True False 2800841.0889270306 1988328.7095546531 1802203.7871999908 1.0 0.7099041489413306 0.6434509241973432 21.417428700997732 -13.999999999999998 0.20705814043664453 2.657774168727568 0.6031752777231338 0.9994885708526334 0.00350102196313736 12.679464519855328 0.14424758677934565 8.539397260875512 0.04019099766529284 1.0000000000000041e-14 13.999999999999998 -2.054598891004434 K(ub)LGSSLDWDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLGSSLDWDR 10 1 P26640;A0A140T936;P26640-2 P26640 VARS Valine--tRNA ligase 1 7915300.0 1893300.0 3113600.0 2908400.0 True False 2482134.634743282 2649063.016717744 2607466.667342775 1.0 1.0672519450145486 1.0504936480258475 21.24314994087968 -10.007192673648252 4.311290337335986 0.9999969838089056 1.0588727965363114 0.9427110812245132 0.006841546150214226 738489.7247092754 1714730.533284043 10.533433088175697 0.0023420434202987375 9.835746485470663e-11 10.007192673648252 0.05887581272740583 K(ub)LHQVVETSHEDLPASQER ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLHQVVETSHEDLPASQER 19 1 O43683-2;O43683-3;O43683;A0A590UK50 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 46122000.0 10779000.0 8598000.0 26745000.0 True False 16352531.05045516 7063619.7235193765 21458839.02725005 1.0 0.43195880207931275 1.3122640746585075 23.963010618059204 -6.732507188009947 1.7143617924227679 0.6591106485601005 1.3119587941562842 0.570753578421427 0.2387466596332916 0.33154628453198326 1.9101549080359967 0.11031621698093008 0.2729400711076729 1.8513682519473258e-07 6.732507188009947 0.6528481455961838 K(ub)LHQVVETSHEDLPASQER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLHQVVETSHEDLPASQER 19 1 O43683-2;O43683-3;O43683;A0A590UK50 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 13758400.0 2594600.0 8597100.0 2566700.0 True False 2157524.8602690995 8550785.715909265 3103385.1029200666 1.0 3.9632385579291816 1.4384006228938626 21.0409457524041 -6.607111742164965 2.1644784270467583 2.983570108199283 1.4472106327157022 0.041504592137251994 1.2784878620853029 0.6206359805038842 5.505655489775497 0.4885020228620223 1.419999181096151 2.471088262476292e-07 6.607111742164965 -1.536359475483581 K(ub)LHQVVETSHEDLPASQER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLHQVVETSHEDLPASQER 19 1 O43683-2;O43683-3;O43683;A0A590UK50 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 51104000.0 10779000.0 9113000.0 31212000.0 True False 13953627.985855317 8605853.53902918 25531736.262164593 1.0 0.6167466660106508 1.8297561242170075 23.734136940151654 -6.82175640262784 1.3642965167040133 0.7937897647604487 1.857240761553314 0.8883700037096087 0.16914975566725163 0.19120689675431968 0.6988352709401381 0.09741819607856107 0.22443064877070648 1.5074523646745612e-07 6.82175640262784 1.0634509967928651 K(ub)LHYQTYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLHYQTYR 8 1 Q13415 Q13415 ORC1 Origin recognition complex subunit 1 1 4581050.0 945150.0 1621000.0 2014900.0 True False 1433861.649720541 1331719.8850691936 1616654.131837959 1.0 0.9287645606036993 1.1274826494962358 20.451474397484542 -6.8097395969238 1.4154506252020835 0.961165733845131 1.1309446217902497 0.8592021381422434 0.030844860600217433 0.2071469546937295 0.8179894586626156 0.01713445959809764 0.039643484488603054 1.5497455682023878e-07 6.8097395969238 0.16977888794511864 K(ub)LIK(ub)DGLIIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLIKDGLIIR 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 2 24031100.0 2007200.0 2432900.0 19591000.0 True False 2631458.6377524505 2069920.8033699256 17563911.25014176 1.0 0.7866058670554903 6.674591421715537 21.32743128751477 -6.898493054331224 0.970767350252711 0.744952816066586 7.274012030630665 0.9857999621587502 0.3249263325254009 0.11252448035719367 0.1837550239731092 0.25173156772212674 0.6501331151139298 1.263301307615251e-07 6.898493054331224 6.529059214564079 up K(ub)LIK(ub)DGLIIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLIKDGLIIR 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 2 29596000.0 2615000.0 5579000.0 21402000.0 True False 2531988.2563786306 7806723.794100664 15796174.153762558 1.0 3.0832385475856072 6.238644319920739 21.271839282738295 -6.9650950356289485 0.35641747078005054 0.7167249800447528 8.71269096125244 0.9999150912383727 0.01984405804204247 0.0779287218937503 0.014746305851226394 0.042657121906905064 0.2701006637829115 1.0836897468219363e-07 6.9650950356289485 7.995965981207687 K(ub)LIK(ub)DGLIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLIKDGLIIR 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 2 27201400.0 2007200.0 2169200.0 23025000.0 True False 2749316.0825404376 2073357.5714148537 17586969.214760154 1.0 0.75413575928273 6.39685241229497 21.39064134903766 -6.896713790511062 0.9818254593011669 0.7437782449385336 6.95112958228271 0.9848587402799163 0.3204200997214428 0.1138642363019618 0.19138274428383942 0.24620229704548924 0.630630569513935 1.268487551286088e-07 6.896713790511062 6.207351337344177 up K(ub)LIK(ub)DGLIIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLIKDGLIIR 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 2 14614300.0 2615000.0 4219300.0 7780000.0 True False 2174488.3641423318 4196569.79343452 9406762.029344331 1.0 1.9299113587530021 4.325965677473089 21.05224455817257 -6.954811211394421 0.5032615403309816 0.9533415270589479 5.406454393134386 0.9995267581949604 0.030479809786895278 0.081609406570987 0.028397708348150544 0.035529464016062 0.19767803775509324 1.109657080396375e-07 6.954811211394421 4.453112866075438 K(ub)LIK(ub)DGLIIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLIKDGLIIR 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 2 10980300.0 3306900.0 3631900.0 4041500.0 True False 4280847.238744313 3429781.5723033147 3305988.4692918872 1.0 0.8011922362614746 0.7722743384465226 22.029464923467224 -13.999999998869269 0.271516639407859 2.5470429761264803 0.7628156457456197 0.9995865951849081 0.0020581487979196423 14.957959922711836 0.16496469515586515 12.784860052771291 0.011919923699053578 1.0000000026036045e-14 13.999999998869269 -1.7842273303808607 K(ub)LIYFQLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLIYFQLHR 9 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 21766400.0 5678400.0 7161800.0 8926200.0 True False 5498142.3001990095 10021544.088293605 6588160.439739985 1.0 1.822714571780157 1.198252078615994 22.390512815777573 -10.410259108658947 5.388634153115314 0.999661090571256 1.5104833251980816 0.47118583153544524 0.25493574529309265 0.0010386645085029185 0.00011367315383447235 0.24699993731932296 0.08228015798942383 3.888131022102899e-11 10.410259108658947 0.5108222346268256 K(ub)LIYFQLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLIYFQLHR 9 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 22252200.0 5678400.0 10892000.0 5681800.0 True False 4721841.195772776 10833322.634107277 6869838.110325015 1.0 2.2943005037538744 1.454906640332426 22.17091809121185 -10.06897559937849 4.87001523666876 0.9999744313525784 1.8746035720518361 0.591425979782695 0.3426811097976418 9.513533055193374e-05 1.8187940327501825e-05 0.33180923035705895 0.11059985260457433 8.5314804637373e-11 10.06897559937849 0.8746291406992578 K(ub)LLADQAEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLLADQAEAR 10 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 17446100.0 5012300.0 6275300.0 6158500.0 True False 6571173.839182253 5339049.70092782 5521277.496503404 1.0 0.8124955801796648 0.8402269718663382 22.647719678182263 -10.338065109819004 8.391774912258033 1.0000004839917707 0.8263612760464621 0.9812292332362108 0.01132129324826819 1.0251225362394888e-07 8.087632468625143e-09 0.010961825514686626 0.0036539316840060922 4.591291746184003e-11 10.338065109819004 -0.17363920794530852 K(ub)LLADQAEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLLADQAEAR 10 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 25681600.0 6125400.0 8867600.0 10688600.0 True False 5930952.529874439 12408478.923923086 7888935.0088733025 1.0 2.092156169084324 1.3301295144644016 22.49983239412395 -10.20732841611984 4.8654476578735375 0.9999010918651154 1.7111428417758474 0.5372969980391955 0.311096079041768 0.00033383593245283607 5.4388600993693805e-05 0.3012590052626187 0.10040582776584622 6.203997067792662e-11 10.20732841611984 0.711241749910732 K(ub)LLADQAEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLLADQAEAR 10 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 15514100.0 6071800.0 1908100.0 7534200.0 True False 9211364.508039126 1567584.646946655 6045062.067642826 1.0 0.1701794175638757 0.6562613022605998 23.13498345236923 -10.76112888825719 14.774630837129948 1.0001734772554385 0.41322035998752865 0.6602091901450313 0.19844209845289015 0.001134250025248466 1.8338114468926155e-05 0.19219084633274502 0.06404691187454137 1.7332895223731877e-11 10.76112888825719 -0.5869531172679099 K(ub)LLADQAEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLLADQAEAR 10 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 15404200.0 5012300.0 5225700.0 5166200.0 True False 6865482.762314391 4994811.294920994 3946049.9612288275 1.0 0.727525138121127 0.5747665674567353 22.710929739705154 -13.999999503105958 0.06821847534616154 2.6014937688894912 4.359048180026442e-09 0.9999314296603777 0.001456394524170886 12.310311134974048 0.06949892605874194 3.172877000035931 0.5280574462069682 1.0000011441414692e-14 13.999999503105958 -2.601493764530443 K(ub)LLADQAEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLLADQAEAR 10 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 26166410.0 6125400.0 16607400.0 3433610.0 True False 5093541.501230376 16517932.63988918 4151561.9757811124 1.0 3.242917061910495 0.8150639343526066 22.280237669558225 -6.663903100431584 1.9587486029324515 2.439046674458606 0.8250390139191065 0.25244990068424566 0.9540942482585112 0.47525767460835544 3.509138265704047 0.3929495604415143 1.058372146356003 2.1681878158401813e-07 6.663903100431584 -1.6140076605394995 K(ub)LLADQAEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLLADQAEAR 10 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 13758800.0 6071800.0 4534800.0 3152200.0 True False 7860064.793071379 4282434.393590425 2578531.9443033207 1.0 0.5448344900878396 0.32805479499053086 22.90610977446168 -11.155391893741685 0.13788823355148191 2.04991464400539 9.68451769794662e-15 0.9997133986673217 0.004740468412530172 3.5316745829894933 0.08311791886514047 1.3850035416612394 0.22857041103636797 6.9921076534300805e-12 11.155391893741685 -2.0499146440053804 K(ub)LLDLVQQSCNYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLLDLVQQSCNYK 13 1 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 12890900.0 4885700.0 4765000.0 3240200.0 True False 6405200.013186096 4054080.5738245253 2904935.1861931216 1.0 0.6329358279957804 0.45352763070830926 22.610812191183257 -13.999999999999927 0.09397864020668291 2.8495347832901388 0.03305832436536361 0.9998234344910629 0.0030221540595540353 12.128980007274741 0.0900217502200718 4.4243638115402835 0.3765244447144477 1.0000000000001677e-14 13.999999999999927 -2.8164764589247753 K(ub)LLDLVQQSCNYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLLDLVQQSCNYK 13 1 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 15009200.0 6515400.0 4329400.0 4164400.0 True False 6308572.193349651 6058151.997522739 3073618.7106779153 1.0 0.960304774495424 0.48721305177708074 22.58888208916566 -6.92349460270706 0.7983962747040201 1.009183733755587 0.40443834965359443 0.9950974259432325 0.01630995688912488 0.09615954777469873 0.09528283635690556 0.014319197604250196 0.04443589215246395 1.1926290874315575e-07 6.92349460270706 -0.6047453841019925 down K(ub)LLDLVQQSCNYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLLDLVQQSCNYK 13 1 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 12534800.0 4885700.0 4976300.0 2672800.0 True False 6692075.321078019 4756430.611576498 2041539.6880439068 1.0 0.7107556898822067 0.3050682471570026 22.67402225270615 -7.063696108475464 0.35186666524685395 1.0410694287610098 5.087030687570552e-12 0.9999189503209623 0.0025660426915131004 0.07362814992044739 0.014899729692747334 0.006006133704584152 0.03351638458868842 8.63582616325074e-08 7.063696108475464 -1.0410694287559228 down K(ub)LLDLVQQSCNYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLLDLVQQSCNYK 13 1 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 14791200.0 6515400.0 4777900.0 3497900.0 True False 5417843.781159829 4752160.5043611 4229294.717537733 1.0 0.8771313268364074 0.7806232310065505 22.369287364599938 -6.9738381142458685 0.13863226846378435 1.1318248755557097 0.5234151591935737 0.9999989655800804 9.112469937984704e-05 0.07507575971994022 0.004193125407536257 0.005533750634044574 0.012647171115865321 1.062091384063843e-07 6.9738381142458685 -0.6084097163621359 K(ub)LLECLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLLECLPK 8 1 H0YJG5;H0YJV1;G3V297;Q9Y6Y1-3;Q9Y6Y1-4;Q9Y6Y1-2;Q9Y6Y1 H0YJG5 CAMTA1 Calmodulin-binding transcription activator 1 1 6541540.0 979440.0 1857500.0 3704600.0 True False 1284055.3249104517 1580368.2404782907 3321283.5290324762 1.0 1.230763355612036 2.5865579656889772 20.29227593319749 -6.936281973920423 0.6932975981491487 0.9833694508804597 2.9153606793607683 0.9976351199523065 0.03403560654765755 0.08950461861295235 0.06264700338590744 0.03226272047889134 0.11872724868383869 1.1580252421912447e-07 6.936281973920423 1.9319912284803085 up K(ub)LLECLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLLECLPK 8 1 H0YJG5;H0YJV1;G3V297;Q9Y6Y1-3;Q9Y6Y1-4;Q9Y6Y1-2;Q9Y6Y1 H0YJG5 CAMTA1 Calmodulin-binding transcription activator 1 1 7794240.0 979440.0 2889500.0 3925300.0 True False 1341565.4363707677 2761832.3357012826 2998224.9840911147 1.0 2.0586639017569297 2.2348704750488944 20.355485994720382 -10.713029794919423 0.35299470244289993 5.2543850665915025e-14 2.265070502721689 0.999256766155957 0.014867678971056203 2.3306597569073064 0.17185599629209575 2.0494216785573394 0.051823504401021146 1.936289119621561e-11 10.713029794919423 2.2650705027216365 K(ub)LLEEVQLLK(ub)PR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLLEEVQLLKPR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 2 24108000.0 3554700.0 4549300.0 16004000.0 True False 3441857.9942444093 6365859.214286096 11812072.290291382 1.0 1.8495415048881447 3.431888331838189 21.71475614455655 -6.961412729805317 0.4150444412584357 0.9262118098441213 4.414425742311736 0.9998190577823379 0.013555414554822618 0.079200279061384 0.01929483020209194 0.0204134063769643 0.13190654964947457 1.0929172236158024e-07 6.961412729805317 3.4882139324676147 K(ub)LLEEVQLLK(ub)PR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLLEEVQLLKPR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 2 14578600.0 3554700.0 4143400.0 6880500.0 True False 2955890.5499108057 4121078.6817994933 8319180.738162445 1.0 1.3941919067077255 2.814441400211343 21.495161419990826 -6.947278521702808 0.5879625180116828 0.9834817078040279 3.296366959748106 0.9989700454754277 0.025007522142314862 0.08459730279897322 0.04062939141583117 0.025980966212405403 0.11890963100791593 1.1290715863340204e-07 6.947278521702808 2.3128852519440777 up K(ub)LLEEVQLLKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLLEEVQLLKPR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 24830900.0 4328700.0 8383200.0 12119000.0 True False 4191287.78791059 11730655.477810482 8944670.337793114 1.0 2.798818900397761 2.1341102759856403 21.998962154485604 -10.289262363596341 5.510420583680202 0.999822250544523 2.466464588191742 0.8664818781444303 0.2713661595729797 0.000592653577810252 7.644102036930967e-05 0.2627796422692586 0.08758305139584678 5.137332041381934e-11 10.289262363596341 1.4666423376472193 K(ub)LLEEVQLLKPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLLEEVQLLKPR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 36581100.0 8262100.0 11441000.0 16878000.0 True False 12534209.740417989 9399264.161058992 13542055.902109804 1.0 0.7498888526454119 1.0804076349896954 23.579367703899944 -6.7043165543864545 1.8153493227440478 0.8453532628768824 1.0795121656674052 0.438130820137953 0.10549399386216858 0.3866166255471383 2.479863800995555 0.04630784312566648 0.11846668406408098 1.9755291650068828e-07 6.7043165543864545 0.23415890279052276 K(ub)LLEEVQLLKPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLLEEVQLLKPR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 16049500.0 4328700.0 7316800.0 4404000.0 True False 3599505.843924636 7277382.946128918 5324856.03820469 1.0 2.0217727826201264 1.4793297383284312 21.77936742991988 -10.372677059595533 5.779527517154148 0.9998222743290769 1.7505512604742806 0.7185199280269117 0.221451445506104 0.0005072514332369819 5.505808898518904e-05 0.2144690026654565 0.0714731467032242 4.2395810316377044e-11 10.372677059595533 0.7507289861452037 K(ub)LLEGEEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLLEGEEER 9 1 Q03252;P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q3BDU5;Q5TCI8;P20700;E9PBF6 Q03252;P02545;P02545-2;P20700 LMNB2;LMNA;LMNB1 Lamin-B2;Prelamin-A/C;Lamin-A/C;Lamin-B1 1 59565000.0 16437000.0 32358000.0 10770000.0 True False 21549066.176134404 27530312.53049611 9655623.713134952 1.0 1.2775640626592877 0.4480762012707798 24.361122016020094 -6.816462974450266 1.3869934696194763 1.150163047940293 0.4312880742983557 0.876082063815799 0.12136102174396168 0.19811556431157473 0.7498050507021523 0.06877372560394857 0.15868997808077215 1.5259384823522505e-07 6.816462974450266 -0.7188749736419372 down K(ub)LLEGEEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLLEGEEER 9 1 Q03252;P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q3BDU5;Q5TCI8;P20700;E9PBF6 Q03252;P02545;P02545-2;P20700 LMNB2;LMNA;LMNB1 Lamin-B2;Prelamin-A/C;Lamin-A/C;Lamin-B1 1 75406800.0 29173000.0 29012000.0 17221800.0 True False 28246919.08349288 40596642.895581365 12710893.937074484 1.0 1.4372060462801233 0.44999222391310495 24.751590184293068 -6.786314002131008 1.5109446159134419 1.2455343268898094 0.4405232140989971 0.7891685802386534 0.18545828560733646 0.24090169717466006 1.0864952905198288 0.09663291872508868 0.22687171386197877 1.635633503591377e-07 6.786314002131008 -0.8050111127908123 down K(ub)LLEGEEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLLEGEEER 9 1 Q03252;P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q3BDU5;Q5TCI8;P20700;E9PBF6 Q03252;P02545;P02545-2;P20700 LMNB2;LMNA;LMNB1 Lamin-B2;Prelamin-A/C;Lamin-A/C;Lamin-B1 1 144809000.0 57096000.0 41257000.0 46456000.0 True False 86618806.27672204 33894366.00758771 37273951.237611905 1.0 0.3913049309327239 0.43032169155659344 26.368176954482173 -9.93734110790148 5.913556237740583 1.0000003063090346 0.41081331124442205 0.9967218271069174 0.015928525824973123 6.433817187371255e-08 1.1542224238548637e-08 0.015422736855374902 0.005140909604023387 1.1552045534991097e-10 9.93734110790148 -0.5891869950646125 K(ub)LLEGEEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLLEGEEER 9 1 Q03252;P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q3BDU5;Q5TCI8;P20700;E9PBF6 Q03252;P02545;P02545-2;P20700 LMNB2;LMNA;LMNB1 Lamin-B2;Prelamin-A/C;Lamin-A/C;Lamin-B1 1 55253100.0 16437000.0 20631600.0 18184500.0 True False 22514203.093222957 19720027.692422442 13889695.621533353 1.0 0.875892769145287 0.6169303689773642 24.424332077542985 -6.959207284596039 0.44646530280607083 1.008659378297192 0.473958029378334 0.9997396586758426 0.0025749135134622483 0.07998551152918362 0.02218683066664125 0.003443634980564067 0.021432245706105763 1.0984814196331334e-07 6.959207284596039 -0.534701348918858 K(ub)LLEGEEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLLEGEEER 9 1 Q03252;P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q3BDU5;Q5TCI8;P20700;E9PBF6 Q03252;P02545;P02545-2;P20700 LMNB2;LMNA;LMNB1 Lamin-B2;Prelamin-A/C;Lamin-A/C;Lamin-B1 1 85834600.0 29173000.0 46606000.0 10055600.0 True False 24258642.083030332 46354924.227433346 12158179.468158726 1.0 1.9108622844087404 0.5011896142638481 24.531995459727344 -6.732258855738043 1.714973987507153 1.5467684677924387 0.501673195725123 0.5697147025691889 0.38284141890039775 0.3320201021268918 1.9140859931330567 0.17683055720037158 0.4376787110224197 1.8524271784904602e-07 6.732258855738043 -1.0450952720673157 K(ub)LLEGEEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLLEGEEER 9 1 Q03252;P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q3BDU5;Q5TCI8;P20700;E9PBF6 Q03252;P02545;P02545-2;P20700 LMNB2;LMNA;LMNB1 Lamin-B2;Prelamin-A/C;Lamin-A/C;Lamin-B1 1 129652000.0 57096000.0 38827000.0 33729000.0 True False 73911897.53041974 36666243.31832399 27590668.088765524 1.0 0.4960803949490453 0.37329129694458324 26.139303276574623 -13.999999999999998 0.1983161046547912 3.783472835712066 0.2922102293157307 0.9994869373133903 0.006142133509532229 12.498085952926978 0.14121201184321197 13.48466823074527 0.07917871557554547 1.0000000000000041e-14 13.999999999999998 -3.4912626063963352 K(ub)LLQQLFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLLQQLFLK 9 1 Q9P287-4;Q9P287-3;Q9P287;Q9P287-2 Q9P287-4 BCCIP BRCA2 and CDKN1A-interacting protein 1 6337200.0 1410300.0 3023800.0 1903100.0 True False 1848916.9573646276 2572660.8266800814 1706185.4678242449 1.0 1.3914420636538751 0.922802649966591 20.81824899802049 -6.68505354716526 1.8837549328041276 1.246532471786099 0.9245009081740024 0.34750157928681213 0.16572145900400218 0.4273795917330388 2.9362583336643473 0.07047774348348397 0.1846976108561895 2.0651255165291444e-07 6.68505354716526 -0.3220315636120966 K(ub)LLQQLFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLLQQLFLK 9 1 Q9P287-4;Q9P287-3;Q9P287;Q9P287-2 Q9P287-4 BCCIP BRCA2 and CDKN1A-interacting protein 1 9818900.0 2866800.0 4752300.0 2199800.0 True False 2775795.0032069813 6649918.1729171 1623606.3874145816 1.0 2.395680576279659 0.584915811700348 21.404469595894117 -6.700815346345487 1.8277063322800164 1.8659383381974326 0.5901614541957846 0.42161800553706996 0.5890421031702358 0.39379851665418264 2.5580019859596943 0.25704334787371397 0.6604458379567869 1.9915199149360845e-07 6.700815346345487 -1.275776884001648 K(ub)LLQQLFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLLQQLFLK 9 1 Q9P287-4;Q9P287-3;Q9P287;Q9P287-2 Q9P287-4 BCCIP BRCA2 and CDKN1A-interacting protein 1 18010100.0 8109000.0 7536300.0 2364800.0 True False 12301945.847308727 6191388.383619348 1897396.24347134 1.0 0.5032852900237588 0.15423545730258842 23.552383194591734 -8.187776039308075 0.3351329964900377 1.1128241794224953 6.371471759289068e-26 0.9984977382522051 0.01345060753294294 0.0942252354767005 0.07828077280245303 0.07161076057392297 0.08964320978380202 6.48969013161196e-09 8.187776039308075 -1.1128241794224953 down K(ub)LLQQLFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLLQQLFLK 9 1 Q9P287-4;Q9P287-3;Q9P287;Q9P287-2 Q9P287-4 BCCIP BRCA2 and CDKN1A-interacting protein 1 7187200.0 1410300.0 2220800.0 3556100.0 True False 1931726.0219244615 2122677.712796475 2716222.42017844 1.0 1.0988502969389933 1.4061116272961072 20.88145905954338 -6.950650215424381 0.5516574681691615 0.9957918242586536 1.5236459277540688 0.9992513367190317 0.004731345229771013 0.08322566266309353 0.03488967714603626 0.005124422957801671 0.025498010538124085 1.1203398517109068e-07 6.950650215424381 0.5278541034954152 K(ub)LLQQLFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLLQQLFLK 9 1 Q9P287-4;Q9P287-3;Q9P287;Q9P287-2 Q9P287-4 BCCIP BRCA2 and CDKN1A-interacting protein 1 9240800.0 2866800.0 3926200.0 2447800.0 True False 2383871.220773704 3905048.78131032 2959623.6626515538 1.0 1.6381123054302011 1.2415199432169768 21.184874871328393 -10.050316394430686 4.20594509621026 0.9999575065834779 1.4398161238798528 0.6211842100064688 0.16190815431625982 113034223.60372224 281843479.14941293 75997.76505819369 0.059252324073306564 8.906018759130366e-11 10.050316394430686 0.4398586172963749 K(ub)LLQQLFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLLQQLFLK 9 1 Q9P287-4;Q9P287-3;Q9P287;Q9P287-2 Q9P287-4 BCCIP BRCA2 and CDKN1A-interacting protein 1 20391800.0 8109000.0 6720400.0 5562400.0 True False 10497260.352286916 6346403.832293619 4550100.275043711 1.0 0.6045771581640349 0.4334559801646182 23.323509516684183 -13.99999999999948 0.11410735325475205 2.8960181269924647 0.1373188456389922 0.9997222750010469 0.003953887247997071 11.990103993093516 0.10315252718515026 5.200134172418549 0.26283118052830745 1.0000000000011984e-14 13.99999999999948 -2.7586992813534725 K(ub)LMAMQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLMAMQR 7 1 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;E7EN40;H0YBD7 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 6430800.0 1519800.0 3831400.0 1079600.0 True False 1263781.0385558384 3810759.4877266414 1305339.368493593 1.0 3.0153637152851367 1.0328841220669402 20.269315094584563 -6.642296642059609 2.035600161303636 2.315570627712253 1.041060701392712 0.16371714362084877 0.861807330266913 0.5275737280210805 4.180669010335549 0.3443857102331025 0.9546561306940452 2.278785030801913e-07 6.642296642059609 -1.274509926319541 K(ub)LMTTNEIQSNIYT ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLMTTNEIQSNIYT 14 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 1 10915200.0 3341000.0 4606400.0 2967800.0 True False 3234941.7837709417 6445759.542058665 2190444.147908444 1.0 1.9925426709054723 0.677120113535726 21.625308318938963 -6.704849880408126 1.8134098123360713 1.6133687723377699 0.6806337532951553 0.4407040392890955 0.4186038928844151 0.38551346326378877 2.4678493623477022 0.18392174550052243 0.470215894020736 1.973104647789284e-07 6.704849880408126 -0.9327350190426146 K(ub)LNHLLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLNHLLER 8 1 O43292;O43292-2 O43292 GPAA1 Glycosylphosphatidylinositol anchor attachment 1 protein 1 15874850.0 539050.0 1859800.0 13476000.0 True False 521938.15281105146 2602427.8387288745 9946231.328665728 1.0 4.986084701248096 19.056340823328153 18.99351933885832 -6.947749419903174 0.5830299086743244 0.8336517078104564 23.908341063649175 0.9990126144002055 0.2433748830118805 0.08440228405769036 0.03980120500356822 0.2541650635434943 1.176354966315045 1.1278480164758973e-07 6.947749419903174 23.074689355838718 K(ub)LNHLLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLNHLLER 8 1 O43292;O43292-2 O43292 GPAA1 Glycosylphosphatidylinositol anchor attachment 1 protein 1 9683050.0 539050.0 2679000.0 6465000.0 True False 448243.958964024 2664567.695260138 7816801.609217375 1.0 5.944458685887155 17.438721599915084 18.773924614292596 -6.957000724004461 0.47582936340719467 0.7129808987521271 23.146056748586364 0.9996422577736411 0.13024908742366129 0.08079052639609162 0.025226592217149964 0.1607199722372227 0.9483472526424176 1.1040767793141478e-07 6.957000724004461 22.433075849834236 K(ub)LNVTEQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLNVTEQEK 9 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 8424100.0 3148300.0 3370700.0 1905100.0 True False 4127451.7881805706 2867804.6988856895 1707978.5270095996 1.0 0.694812403889968 0.41380944337147463 21.976819932770635 -7.1307833825196365 0.21664161655919778 1.1450468458743048 2.542788790422159e-12 0.9999886882549835 0.0008050817850665246 0.08031058964145137 0.00867545110216183 0.010466470155521015 0.03231489609761678 7.399742675267387e-08 7.1307833825196365 -1.145046845871762 down K(ub)LNVTEQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLNVTEQEK 9 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 13499000.0 5040200.0 4745400.0 3713400.0 True False 4880201.609865993 6640262.966934086 2740749.140387901 1.0 1.360653411020948 0.5616057203143212 22.2185093186586 -6.783979435063691 1.5200505789238672 1.203161002867648 0.5544343521231924 0.7812844404253104 0.15279916745118008 0.24445984233323467 1.1158084426293464 0.07914849466725597 0.1861706372468633 1.6444495901964923e-07 6.783979435063691 -0.6487266507444557 K(ub)LNVTEQEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLNVTEQEK 9 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 17117100.0 3470100.0 3116000.0 10531000.0 True False 5264395.3982915385 2559925.4545808784 8449543.234098727 1.0 0.48627150145516324 1.6050358293453544 22.3278364204284 -6.7818374959518035 1.5285830571656196 0.709809397851455 1.6144345525728192 0.773880343507606 0.21742713455577764 0.2477296467298072 1.143399439131566 0.11201577357566324 0.26392137676823385 1.652580043961924e-07 6.7818374959518035 0.9046251547213642 K(ub)LNVTEQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLNVTEQEK 9 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 9545300.0 3148300.0 3659000.0 2738000.0 True False 4312311.58960844 3497333.281305067 2091340.7908800554 1.0 0.8110112659142579 0.4849697772117506 22.040029994293526 -6.962829159968029 0.39353700408642195 1.0192518088109994 0.2649475875160039 0.9998611644789037 0.0025065262644420904 0.07870556175243591 0.017507317485430707 0.00420236716646348 0.02738575854002349 1.0893585340682975e-07 6.962829159968029 -0.7543042212949955 down K(ub)LNVTEQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLNVTEQEK 9 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 13426700.0 5040200.0 6463300.0 1923200.0 True False 4191149.6187189976 6428480.920035401 2325332.228127899 1.0 1.5338228182844573 0.5548196651682944 21.998914594092877 -6.758646505699474 1.6176501896640672 1.3105960889096457 0.5514902108715577 0.6853896928598568 0.2244851054304504 0.2851947366975273 1.4705786743693852 0.10951085070975536 0.26351581593829265 1.743225195471231e-07 6.758646505699474 -0.759105878038088 K(ub)LNVTEQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLNVTEQEK 9 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 12504500.0 3470100.0 2907500.0 6126900.0 True False 4492112.855897261 2745695.0691020894 5011867.0673028445 1.0 0.6112257543791518 1.115703729643223 22.09896274252085 -6.7008294610400645 1.8273254255559148 0.7587911682881158 1.1142555068982591 0.42175362494684154 0.1640809549204674 0.3938157558209896 2.556979756030611 0.07160987564335025 0.18401346290451115 1.9914551910223942e-07 6.7008294610400645 0.35546433861014337 K(ub)LPEEEVESSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLPEEEVESSR 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 23144400.0 11297700.0 9511000.0 2335700.0 True False 14811394.107082421 8091995.873587631 2094024.1696164638 1.0 0.5463358692020929 0.1413792756088474 23.82020410340122 -7.8671524578513665 0.39250376367732653 1.056967527946122 9.586440964338353e-18 0.9979598994974761 0.01584106215084399 0.10857242196158484 0.07488997464486519 0.038348314250086835 0.08068409629834991 1.3578366981732764e-08 7.8671524578513665 -1.056967527946122 down K(ub)LPEEEVESSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLPEEEVESSR 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 24055800.0 10593100.0 9103400.0 4359300.0 True False 10256827.83886978 12738435.093603862 3217468.553803244 1.0 1.2419468566421346 0.3136904123134608 23.29008127734493 -6.837466933426613 1.2940789599222058 1.1287811868888207 0.28465249615095545 0.9200208417036809 0.11118979618888002 0.17177298799281177 0.5598655930437777 0.06740081160599427 0.15519140679831037 1.4538950789279305e-07 6.837466933426613 -0.8441286907378652 down K(ub)LPEEEVESSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLPEEEVESSR 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 63399100.0 33775200.0 18938000.0 10685900.0 True False 51239447.69786929 15558365.936730636 8573827.18120365 1.0 0.303640391060999 0.16732864163093192 25.610751589386815 -13.999999999999998 0.22930014698551635 5.381722488926776 0.10060983104162016 0.9995088461877103 0.008081747820746877 13.269579466392553 0.15162472911245156 26.46143001802033 0.07106734650818954 1.0000000000000041e-14 13.999999999999998 -5.281112657885156 K(ub)LPEEEVESSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLPEEEVESSR 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 22702000.0 11297700.0 8372100.0 3032200.0 True False 15474764.998862633 8002192.939167576 2316056.810119245 1.0 0.5171124045990826 0.14966668704109376 23.883414164924112 -8.064927820987021 0.35438872751573103 1.0896425361097073 1.4771739847946252e-15 0.9983215264618603 0.014265952691807759 0.09438546152564002 0.07701542955424101 0.056780954248444857 0.08627704369421217 8.611368597909438e-09 8.064927820987021 -1.0896425361097057 down K(ub)LPEEEVESSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLPEEEVESSR 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 32269000.0 10593100.0 20268600.0 1407300.0 True False 8808632.003899097 20159409.028797917 1701559.9233799847 1.0 2.2885970284460124 0.19316960029966032 23.070486552779208 -6.740326949081036 1.6855993320495675 1.7664163171523488 0.1918754925560028 0.6063868703558524 0.5414079307677475 0.31721530952443916 1.7698264429967212 0.25409095773136925 0.6232686285258756 1.8183314522345916e-07 6.740326949081036 -1.574540824596346 K(ub)LPEEEVESSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLPEEEVESSR 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 47863700.0 33775200.0 7309200.0 6779300.0 True False 43722662.20872627 6902436.594696824 5545536.961492137 1.0 0.15786862569679527 0.12683438476409484 25.381877911479265 K(ub)LPFPDETHER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLPFPDETHER 11 1 O43292;O43292-2;E9PLG8;E9PLV6;E9PPZ9 O43292 GPAA1 Glycosylphosphatidylinositol anchor attachment 1 protein 1 16497800.0 2093300.0 2919500.0 11485000.0 True False 2744336.571546039 2483921.98012187 10296642.371899256 1.0 0.9051083623910376 3.7519604842413985 21.388025997016918 -6.8991871146398465 0.966373250524843 0.8789839775925378 4.0459211415766205 0.9861581056049841 0.15532611950626407 0.11200675633747742 0.18080521349755238 0.12072901602202163 0.31286121189921506 1.2612839966022538e-07 6.8991871146398465 3.1669371639840826 up K(ub)LPFPDETHER ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLPFPDETHER 11 1 O43292;O43292-2;E9PLG8;E9PLV6;E9PPZ9 O43292 GPAA1 Glycosylphosphatidylinositol anchor attachment 1 protein 1 67800700.0 5897700.0 20311000.0 41592000.0 True False 8947242.079624217 16686343.359432686 33371322.96957881 1.0 1.864970592159669 3.729788763129163 23.093011620280976 -6.958550236549718 0.455405362181249 0.9430770734695293 4.726280344570995 0.9997125944022759 0.01931081810637856 0.0802231182582066 0.02307592233218926 0.025134649246989535 0.15413638692836806 1.1001445798875531e-07 6.958550236549718 3.7832032711014656 K(ub)LPFPDETHER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLPFPDETHER 11 1 O43292;O43292-2;E9PLG8;E9PLV6;E9PPZ9 O43292 GPAA1 Glycosylphosphatidylinositol anchor attachment 1 protein 1 53738700.0 5897700.0 24672000.0 23169000.0 True False 7634688.911047309 23298981.511568982 18952479.734015495 1.0 3.051726374581631 2.482416763123311 22.864137942373425 -9.978869202409609 5.089666276100229 0.9999895542523204 2.767071568867282 0.9277742081338394 0.23241967568408647 2.959383434199194e-05 5.937010891945811e-06 0.2250408111282528 0.07501312776244498 1.0498585696594166e-10 9.978869202409609 1.7670820146149615 K(ub)LPIQEFHLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLPIQEFHLSR 11 1 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 1 4487000.0 1293800.0 1250400.0 1942800.0 True False 1252729.0271903132 1749691.240749858 1433922.3972493187 1.0 1.3967036787469977 1.1446389172169145 20.256642954130733 -10.316334355451053 5.816234005672687 0.9999714195056759 1.2706712979819488 0.6059023955864993 0.10290500798084153 3.814244162234509e-05 4.48349363440387e-06 0.09964785257915582 0.03321244851259451 4.8268704694450255e-11 10.316334355451053 0.27069987847627286 K(ub)LPIQEFHLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLPIQEFHLSR 11 1 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 1 4307200.0 1322300.0 1417600.0 1567300.0 True False 1811190.0438138796 1354965.7446236848 1197136.0195567228 1.0 0.7481079907939926 0.6609665416644385 20.788506502074462 -13.999999999999998 0.14806702149403903 2.21452350249269 0.5629298072501763 0.9995728183842092 0.0029711555099932127 11.950963043005268 0.12108344717022994 4.178595570158995 0.08820448233642356 1.0000000000000041e-14 13.999999999999998 -1.6515936952425136 K(ub)LQEEEDRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLQEEEDRR 9 2 Q8NBR6-2;Q8NBR6 Q8NBR6-2 FAM63B Protein FAM63B 1 129733000.0 51958000.0 43217000.0 34558000.0 True False 68117441.16198777 36769192.05854659 30982269.663743544 1.0 0.5397911523292107 0.4548360762710634 26.021520905272503 -13.999999999999998 0.2376071893799943 4.01120792653211 0.4164105043237356 0.9995210734173053 0.005241161331670766 13.540187736523743 0.15429185074810417 19.319029636565478 0.04210412191682257 1.0000000000000041e-14 13.999999999999998 -3.5947974222083747 K(ub)LQEEEDRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLQEEEDRR 9 2 Q8NBR6-2;Q8NBR6 Q8NBR6-2 FAM63B Protein FAM63B 1 89270000.0 28131000.0 39295000.0 21844000.0 True False 27237996.803130902 54985698.42071789 16122401.094046796 1.0 2.018713006618662 0.5919084729532529 24.699117269600514 -6.715007195478247 1.7770965455834022 1.6230613000767107 0.5947094062328494 0.48887643866241126 0.42896313318580803 0.36514397716457114 2.2507537199387966 0.19186216590539812 0.4845308138821973 1.927492977835398e-07 6.715007195478247 -1.0283518938438614 K(ub)LQEEEDRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLQEEEDRR 9 2 Q8NBR6-2;Q8NBR6 Q8NBR6-2 FAM63B Protein FAM63B 1 118915000.0 51958000.0 40741000.0 26216000.0 True False 71168276.71215428 38940927.90752936 20024320.73546803 1.0 0.5471669359794817 0.2813658228153813 26.084730966795394 -8.790603641766042 0.2031321991062364 1.3551362818362127 2.4717002393687072e-18 0.9996152189880706 0.005819520047815915 0.3175334129991674 0.060553796212418964 0.20683457190412677 0.1328466724709475 1.6195574501376443e-09 8.790603641766042 -1.3551362818362127 down K(ub)LQEYNVGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLQEYNVGGK 10 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 3525840.0 1363000.0 1485900.0 676940.0 True False 1786906.199310777 1264209.5119928343 606896.742466999 1.0 0.7074851004940547 0.339635478740341 20.76903247379817 -7.0304841291354 0.3112599102264997 1.0581205526240565 2.2516093672279285e-12 0.9999592365629556 0.0017249680119483168 0.07265284075220414 0.011806400361517122 0.005958110255812722 0.031149742808700063 9.322145365823113e-08 7.0304841291354 -1.058120552621805 down K(ub)LQEYNVGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLQEYNVGGK 10 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 3734300.0 1303600.0 1206700.0 1224000.0 True False 1262217.9315545643 1688541.602857369 903397.6807870937 1.0 1.3377575778675073 0.7157224265341067 20.267529593455194 -6.759310178631702 1.6157076480354298 1.1963640508793503 0.7135774417243774 0.6878918222424191 0.14204510029260048 0.28408074407801426 1.4615653970510432 0.06938004500936952 0.16680233540582676 1.7405632969548757e-07 6.759310178631702 -0.48278660915497285 K(ub)LQEYNVGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLQEYNVGGK 10 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 10791900.0 4092000.0 3628200.0 3071700.0 True False 6207863.165271595 2980719.362744012 2464577.148626065 1.0 0.48015223328679874 0.3970089357661026 22.565665327081213 -13.999999999999998 0.2579796131082823 4.765785700928163 0.3660273622643638 0.9995582387479828 0.005608123366703043 14.328701803358275 0.1607241202868935 28.095993046924725 0.03674001966360986 1.0000000000000041e-14 13.999999999999998 -4.399758338663799 K(ub)LQEYNVGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLQEYNVGGK 10 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 3513400.0 1363000.0 1063200.0 1087200.0 True False 1866937.9336900248 1016224.3084677648 830425.75158685 1.0 0.544326777087434 0.44480629837838465 20.83224253532106 -13.999999999999998 0.2138053591107052 3.6774161429480205 0.38830645566328426 0.9994924869437599 0.005445091187595202 12.838486268871247 0.14653069011038394 14.466812287824698 0.05741784174020298 1.0000000000000041e-14 13.999999999999998 -3.2891096872847365 K(ub)LQEYNVGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLQEYNVGGK 10 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 4538360.0 1303600.0 2465400.0 769360.0 True False 1084001.1592718721 2452118.4008564153 930229.6188812796 1.0 2.2620994266311607 0.85814448713885 20.04793486888947 -6.669778685966012 1.937887643097556 1.8057253594605456 0.863788236148574 0.2782099658521311 0.5361356604823067 0.46160786446593693 3.3417867477055414 0.22272948140725965 0.5953076549933665 2.1390518606479516e-07 6.669778685966012 -0.9419371233119715 K(ub)LQEYNVGGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLQEYNVGGK 10 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 10910900.0 4092000.0 4639600.0 2179300.0 True False 5297174.665378974 4381402.181463817 1782689.7615063216 1.0 0.8271205799762618 0.3365359600387621 22.336791649173662 -6.9526936509004855 0.5284442306009234 1.0078246944977778 0.13362039384359034 0.9993960745909809 0.006906009642932929 0.0824217865843624 0.03162283331104869 0.0077224844934401455 0.040560727408470526 1.1150808285307695e-07 6.9526936509004855 -0.8742043006541874 down K(ub)LQFLELQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLQFLELQK 9 1 Q6NUQ1 Q6NUQ1 RINT1 RAD50-interacting protein 1 1 5074300.0 1267400.0 2327400.0 1479500.0 True False 1053899.2553399587 2314861.834247272 1788856.6095649041 1.0 2.1964735457570486 1.6973696494242883 20.007305532344756 -10.430845544795984 5.47946642618166 0.9992794713759207 1.9469215975906722 0.8275676833507705 0.203758312441721 0.001794736653607712 0.0001864190894672684 0.19742177084437976 0.06576271256150672 3.708125764367543e-11 10.430845544795984 0.9476421262147515 K(ub)LSGLEQPQGALQTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLSGLEQPQGALQTR 15 1 Q6RFH5;Q6RFH5-2;E9PS41;H0YFP2 Q6RFH5 WDR74 WD repeat-containing protein 74 1 26226600.0 3173600.0 3491000.0 19562000.0 True False 3072855.805140814 4884974.505324504 14438125.352579353 1.0 1.589718104296355 4.698601648806533 21.55114863886191 -6.9386313898683625 0.6721740075621742 0.9641404474606208 5.5042621950993444 0.9979791080201419 0.07293843793690952 0.0883965637660714 0.05749451712703827 0.07028447814124918 0.2692288699842437 1.1517775525310427e-07 6.9386313898683625 4.5401217476387234 K(ub)LSGLEQPQGALQTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLSGLEQPQGALQTR 15 1 Q6RFH5;Q6RFH5-2;E9PS41;H0YFP2 Q6RFH5 WDR74 WD repeat-containing protein 74 1 15408000.0 3173600.0 5137700.0 7096700.0 True False 2638989.014318206 5110022.190346397 8580587.158566585 1.0 1.9363559918670572 3.251467555193069 21.331553914296187 -6.9663274116960165 0.33448874243748444 0.8479360621008817 4.383230111626475 0.9999379504639401 0.007274414141123428 0.07751336031404815 0.013287267867761842 0.0188946586274137 0.1143013849708463 1.0806189727399475e-07 6.9663274116960165 3.535294049525594 K(ub)LSPTEPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLSPTEPK 8 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 16340900.0 5818900.0 8025200.0 2496800.0 True False 7628634.250307759 6827871.441984589 2238455.086996783 1.0 0.8950319569599414 0.2934280257185587 22.862993364696724 -6.936812083963455 0.688580603927501 1.0072678717205665 0.14535663372560337 0.9977158486175807 0.014878069740214654 0.08925151876048319 0.061460619480248176 0.014154171975673447 0.052547170530312735 1.1566125917195942e-07 6.936812083963455 -0.8619112379949632 down K(ub)LSPTEPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLSPTEPK 8 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 14646700.0 6065200.0 6226600.0 2354900.0 True False 5872663.545922631 8712913.851290047 1738081.044514317 1.0 1.4836392010469237 0.2959612841639907 22.48558355527235 -6.796134034770822 1.471554376645 1.2681613198896202 0.2810704806954552 0.8206622780995662 0.20650820310726262 0.2263116752762408 0.9678589650913434 0.11042001277513844 0.2574347693081375 1.5990644388457053e-07 6.796134034770822 -0.9870908391941651 down K(ub)LSPTEPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLSPTEPK 8 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 5179100.0 2158500.0 946900.0 2073700.0 True False 3274602.307487468 777918.2968365322 1663832.286065003 1.0 0.2375611521001499 0.5081020929657946 21.642888274797336 -10.34983293162681 5.785861586179111 1.000108544416197 0.37283162253696056 0.8775321761183474 0.110447876608891 0.00015467100700720325 1.738055741415904e-05 0.10695897894414924 0.035646898894182925 4.4685545953602803e-11 10.34983293162681 -0.6272769218792364 K(ub)LSPTEPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLSPTEPK 8 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 12226900.0 5818900.0 4777800.0 1630200.0 True False 7970304.579859781 4566700.997928226 1245180.3350228886 1.0 0.5729644271647856 0.1562274468367675 22.926203426219615 -7.746305538776107 0.3951642896645231 1.0497941302181824 8.199104704505108e-26 0.9982403693143319 0.014450114240730892 0.11688182602470186 0.0663727915744443 0.031135154583823942 0.07746274202791943 1.7934714236731315e-08 7.746305538776107 -1.0497941302181824 down K(ub)LSPTEPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLSPTEPK 8 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 13669560.0 6065200.0 7398000.0 206360.0 True False 5043482.5339181945 7358145.505611965 249508.92189916456 1.0 1.4589414072770763 0.049471554669056304 22.265988830706625 -6.818977931451151 1.3760763781730965 1.2476095521862178 0.019296459949459485 0.8821162617264765 0.20152927712359658 0.19477079714307946 0.7249438798637189 0.1150920274169193 0.26537134892368597 1.5171274578948945e-07 6.818977931451151 -1.2283130922367584 down K(ub)LSSETYSQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLSSETYSQAK 11 1 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 1 2410790.0 569980.0 920580.0 920230.0 True False 747249.2996941721 783233.0523927348 825013.4270694682 1.0 1.0481549500458411 1.1040671799988608 19.51123011427833 -6.969163662524531 0.2774337875517432 0.9872954239363365 1.1666245262846138 0.9999750867209435 0.00021217523811183217 0.07657500570093528 0.009997574156657658 0.0010482748586289339 0.00514887662103473 1.0735847590230587e-07 6.969163662524531 0.17932910234827726 K(ub)LSSETYSQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLSSETYSQAK 11 1 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 1 2818950.0 576720.0 994230.0 1248000.0 True False 558412.3392805681 1391231.2238409556 921111.3608025253 1.0 2.49140487409958 1.6495182788926932 19.09097129568029 -10.085128258528892 6.342507492637425 0.999998313485278 2.070461576496144 0.6831058156691019 0.3436987632576799 8.196703980268071e-06 1.1821589703518453e-06 0.33278541702957565 0.11092829885075284 8.219998560224283e-11 10.085128258528892 1.0704632630108661 K(ub)LSSETYSQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLSSETYSQAK 11 1 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 1 2582520.0 576720.0 1503100.0 502700.0 True False 479568.23302797973 1495002.5019580112 607812.2457778143 1.0 3.1173926857469465 1.2674155707522694 18.871376571114567 -6.613521794821204 2.1404492716889516 2.4112716950865027 1.2741884722651213 0.06149817253780765 0.912060558908492 0.6030474016276158 5.240527124327835 0.35122756310811265 1.0121757313006499 2.434883603639114e-07 6.613521794821204 -1.1370832228213814 K(ub)LSTIALALGVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLSTIALALGVER 13 1 P30153;C9J9C1;E9PPI5;E9PNM7;E9PHZ6;P30154;P30154-2;P30154-4;P30154-5 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 10806000.0 1706000.0 3945300.0 5154700.0 True False 1651843.9638171857 5520678.864467704 3804529.43231473 1.0 3.342130967207199 2.3032014619122876 20.65564598292228 -10.583756773223632 6.784599689460462 0.9972668508928934 2.8226662145597348 0.8040656260874065 0.4241411944491144 0.01752898701148946 0.0010754226827335656 0.4105375491635574 0.13689098187849524 2.6076135360000503e-11 10.583756773223632 1.8253993636668415 K(ub)LSTIALALGVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLSTIALALGVER 13 1 P30153;C9J9C1;E9PPI5;E9PNM7;E9PHZ6;P30154;P30154-2;P30154-4;P30154-5 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 26791800.0 2902000.0 3590800.0 20299000.0 True False 4402546.1646183245 2949993.6849515503 16286893.752632234 1.0 0.6700653609630685 3.6994260011454565 22.06990670140263 -6.879918052944506 1.0803121998778182 0.7957612501274424 3.913729987621671 0.9736168475994824 0.2204143250600037 0.12770011330503275 0.2727556582111771 0.157185384217411 0.3800177828960717 1.3185055039796132e-07 6.879918052944506 3.1179687374942286 up K(ub)LSTIALALGVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLSTIALALGVER 13 1 P30153;C9J9C1;E9PPI5;E9PNM7;E9PHZ6;P30154;P30154-2;P30154-4;P30154-5 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 6983290.0 760490.0 1666900.0 4555900.0 True False 1041663.704469499 1593250.846298831 3479890.2517057867 1.0 1.5295251619717765 3.340704141628928 19.990458155766632 -6.9484714612507075 0.5753792046369244 0.9779543212167308 3.9811506611160667 0.9990758137762268 0.030467342908114307 0.08410537978663872 0.038547650233972594 0.03208370310192093 0.15111208394954456 1.125974457509368e-07 6.9484714612507075 3.003196339899336 K(ub)LSTIALALGVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLSTIALALGVER 13 1 P30153;C9J9C1;E9PPI5;E9PNM7;E9PHZ6;P30154;P30154-2;P30154-4;P30154-5 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 8087000.0 1706000.0 3938900.0 2442100.0 True False 1418614.5886144608 3917680.363889564 2952731.8190053715 1.0 2.7616241897779314 2.081419324673137 20.436051258356557 -10.363267066060779 5.643363846826149 0.9996373915739453 2.4215217572255416 0.853442521038241 0.27769247334426145 0.0012671933522662463 0.00014297544770116959 0.2689371207600692 0.08962486038578542 4.332443761478747e-11 10.363267066060779 1.4218843656515965 K(ub)LSTIALALGVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLSTIALALGVER 13 1 P30153;C9J9C1;E9PPI5;E9PNM7;E9PHZ6;P30154;P30154-2;P30154-4;P30154-5 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 16859300.0 2902000.0 4819300.0 9138000.0 True False 3756696.2069720905 4551101.718494828 7474977.763797904 1.0 1.2114638681851335 1.9897743527743919 21.84103302349508 -6.946788398397767 0.5930548910441763 0.9910820248622708 2.2495258063447845 0.9989245506570272 0.013956798212348883 0.08480156059608286 0.04150117837887355 0.014424354789866289 0.06526353418446372 1.1303465200464886e-07 6.946788398397767 1.2584437814825136 K(ub)LTAQEACGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLTAQEACGK 10 1 Q9Y232-2;Q9Y232;Q9Y232-3;Q9Y232-4 Q9Y232-2 CDYL Chromodomain Y-like protein 1 3905820.0 935660.0 1991400.0 978760.0 True False 1226659.32094433 1694290.8824164036 877487.3041288743 1.0 1.3812236645396154 0.7153471947315825 20.226303195481297 -6.751451466411476 1.6447021292791804 1.2237734323900467 0.7138938207057869 0.6551110903318766 0.16020452463021598 0.2975148264573348 1.5839001127852668 0.07693646664453634 0.18648039277517983 1.772346098561174e-07 6.751451466411476 -0.5098796116842598 K(ub)LTAQEACGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLTAQEACGK 10 1 Q9Y232-2;Q9Y232;Q9Y232-3;Q9Y232-4 Q9Y232-2 CDYL Chromodomain Y-like protein 1 2355160.0 935660.0 945960.0 473540.0 True False 1281598.787260755 904164.3593285991 361699.6048624326 1.0 0.7054972026472721 0.28222530206627056 20.289513257004188 -7.116521408535171 0.3710308837062917 1.0358538845627645 1.0720886781400299e-12 0.999864943049928 0.0034236357863992374 0.07798631664266274 0.01807600663126033 0.006843772360634978 0.03678712810571949 7.646779927280084e-08 7.116521408535171 -1.0358538845616925 down K(ub)LTLSSNPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLTLSSNPLR 10 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 15012300.0 3379100.0 5450900.0 6182300.0 True False 4430032.823250944 4637646.96744178 5542614.900809121 1.0 1.0468651480641806 1.2511453350229849 22.07888595744215 -6.942905978320288 0.6319522991172278 0.9977712701784722 1.3112856723336968 0.9985202718467182 0.004194330467200493 0.08646559912207914 0.04875808930143287 0.004179103711315022 0.01736946492445177 1.1404966702882827e-07 6.942905978320288 0.3135144021552245 K(ub)LTLSSNPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLTLSSNPLR 10 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 29285500.0 7488000.0 9456400.0 12341100.0 True False 7250297.538723974 13232389.834474538 9108595.684935952 1.0 1.8250823174911235 1.2563064669121196 22.789608771187396 -9.782902422552487 6.052423052392328 0.9999999767729562 1.5406943922026246 0.5464699227489853 0.23220176865958062 7.294292799715242e-08 1.4391808898891981e-08 0.22482840579363317 0.07494279858101498 1.6485327428752188e-10 9.782902422552487 0.5406944154296685 K(ub)LTLSSNPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLTLSSNPLR 10 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 83048200.0 14813200.0 23143000.0 45092000.0 True False 22472707.38998072 19012950.832915682 36179546.43547434 1.0 0.8460462953116391 1.6099326978112443 24.421670607278816 -6.854256988240267 1.2142857903923665 0.9174364714668424 1.6430870368650696 0.9462833881101188 0.07645010442805156 0.15283705709414674 0.43151491848550727 0.04920435509610386 0.11422233692534964 1.3987593795482227e-07 6.854256988240267 0.7256505653982273 K(ub)LTLSSNPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLTLSSNPLR 10 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 21183900.0 3379100.0 4455100.0 13349700.0 True False 4628444.586743913 4258258.950954421 10196775.805701777 1.0 0.9200194301019136 2.20306749159444 22.14209601896504 -6.892050068813711 1.0101526041407087 0.9344103383217433 2.317968104862227 0.9821791523931315 0.07834700712034978 0.11749648542950328 0.2122463548129293 0.05893053509698668 0.14804509590219314 1.2821827542288446e-07 6.892050068813711 1.3835577665404837 up K(ub)LTLSSNPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLTLSSNPLR 10 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 24821100.0 7488000.0 9307600.0 8025500.0 True False 6226603.774645424 9257458.111386044 9703594.944280587 1.0 1.4867588249443755 1.5584089329392348 22.570014046621672 -11.759565583580644 0.31707613801897433 6.524904069394851e-22 1.5747421474377374 0.9994750618665232 0.005683864664492297 4.563645382108813 0.16934431345252657 3.0780577487694796 0.024102959221443697 1.7395399871811878e-12 11.759565583580644 1.5747421474377374 K(ub)LTLSSNPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLTLSSNPLR 10 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 67943700.0 14813200.0 23020900.0 30109600.0 True False 19175979.41182594 21739766.678002506 24629961.75058538 1.0 1.1336978524599095 1.2844174068833187 24.192796929371266 -6.9695700394379 0.2682691133259021 0.9617372502886224 1.4608985604775866 0.9999788251546855 0.0005345944498536125 0.07644256054213945 0.009528871738359665 0.002986068646023813 0.014051413042047252 1.0725806569103078e-07 6.9695700394379 0.49916131018896415 K(ub)LTTLADLFRPPIDLMHK ddPTM_RPMI8226_Bortezomib_2h_R1 2 KLTTLADLFRPPIDLMHK 18 2 O94888 O94888 UBXN7 UBX domain-containing protein 7 1 39032800.0 13170100.0 16108400.0 9754300.0 True False 12752022.38444827 22540568.1241963 7199356.20727251 1.0 1.7676073209913474 0.5645658382824427 23.60422273111054 -6.734335326319817 1.7073103080616079 1.4596966880092743 0.5646813289217794 0.5792814644056778 0.32258940135374053 0.3281760873192798 1.8759272881988556 0.149611768025999 0.36945922859011127 1.843591400523706e-07 6.734335326319817 -0.895015359087495 K(ub)LTTLADLFRPPIDLMHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLTTLADLFRPPIDLMHK 18 2 O94888 O94888 UBXN7 UBX domain-containing protein 7 1 46958000.0 11933000.0 18912000.0 16113000.0 True False 18103233.41915588 15537005.83986958 12928258.487421231 1.0 0.8582447941829632 0.7141408492110163 24.109744064346707 -6.97092049230499 0.23516522346761662 1.054947633068941 0.5132947121787118 0.9999886960760881 0.0003923276827762562 0.07600516823295217 0.007953559183629317 0.0035657740893397945 0.014172710037227797 1.0692506124721937e-07 6.97092049230499 -0.5416529208902291 K(ub)LTTLADLFRPPIDLMHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLTTLADLFRPPIDLMHK 18 2 O94888 O94888 UBXN7 UBX domain-containing protein 7 1 6372470.0 2040470.0 2128900.0 2203100.0 True False 2794886.9006283833 2034838.1586691372 1682773.1542687526 1.0 0.7280574245103221 0.6020898927575242 21.414358472713236 -13.999999999996016 0.10308221422602287 2.3317127968358355 0.3461661148112718 0.99977819470348 0.002472995439427395 12.057688716589743 0.09622435652441834 3.3903965323133796 0.22788181735251542 1.0000000000091743e-14 13.999999999996016 -1.9855466820245637 K(ub)LTTLADLFRPPIDLMHK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 KLTTLADLFRPPIDLMHK 18 2 O94888 O94888 UBXN7 UBX domain-containing protein 7 1 41961900.0 13170100.0 19881400.0 8910400.0 True False 10951521.684356 19774294.952051073 10773523.442965262 1.0 1.8056207641261584 0.983746711505397 23.384628006544816 -10.38062530318205 3.623056882844472 0.9977516993037722 1.3946837374479621 0.2351739980600278 0.33552867734493746 80015420.04693693 105025294.31088477 1782531.600820063 0.1227909262452652 4.1626960107631926e-11 10.38062530318205 0.39693203814419 K(ub)LYDIDVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLYDIDVAK 9 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9;K7EMA7 P62750 RPL23A 60S ribosomal protein L23a 1 20968500.0 4641700.0 6356000.0 9970800.0 True False 6085313.650286743 5407709.575493946 8939117.262667233 1.0 0.8886492769750877 1.4689657388894024 22.53690019381644 -6.856988048274357 1.2007958356889787 0.9400018437114166 1.4955015613228957 0.9498779154493147 0.05629705894696145 0.14994003974865766 0.41253771750849255 0.03660751958562094 0.08518727173589365 1.3899908830488786e-07 6.856988048274357 0.5554997176114791 K(ub)LYDIDVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLYDIDVAK 9 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9;K7EMA7 P62750 RPL23A 60S ribosomal protein L23a 1 21665500.0 6175100.0 3401400.0 12089000.0 True False 5979074.8305788515 4759596.758066673 8922528.237773828 1.0 0.7960423465056186 1.492292451691897 22.511490836256662 -6.828310369115535 1.335698366975013 0.8908887471417274 1.5103557703820494 0.9024007276139173 0.09130291710122838 0.18290949154266947 0.6388442271980763 0.05368298181637506 0.12353478586741527 1.484874095813342e-07 6.828310369115535 0.619467023240322 K(ub)LYDIDVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLYDIDVAK 9 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9;K7EMA7 P62750 RPL23A 60S ribosomal protein L23a 1 31114400.0 7712700.0 8741700.0 14660000.0 True False 11700729.7738979 7181675.335786162 11762444.574293742 1.0 0.613780120946568 1.0052744402775216 23.48009517763987 -10.941434916466546 10.925841036452196 1.0436475618751608 0.8095272806120447 0.23989742019414406 0.15982688659317548 0.09487330131182944 0.0005085425989122649 0.08639983160506653 0.05158390583762914 1.1443663621384055e-11 10.941434916466546 -0.23412028126311613 K(ub)LYDIDVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLYDIDVAK 9 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9;K7EMA7 P62750 RPL23A 60S ribosomal protein L23a 1 20275800.0 4641700.0 5320100.0 10314000.0 True False 6357861.927225962 5085040.390781931 7878045.623497768 1.0 0.799803526560794 1.239102974187281 22.60011025533933 -6.782841797065747 1.5251707317599374 0.8870601818758052 1.2428743864280059 0.777185522355089 0.08476640055082184 0.24619058891972054 1.1313548753919758 0.04377011680362037 0.10302035895177346 1.6487628864304074e-07 6.782841797065747 0.3558142045522007 K(ub)LYDIDVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLYDIDVAK 9 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9;K7EMA7 P62750 RPL23A 60S ribosomal protein L23a 1 15854300.0 6175100.0 6241700.0 3437500.0 True False 5134869.2533137 6208074.723219553 4156265.356795776 1.0 1.2090034657091373 0.8094198998569636 22.29189611169094 -6.764573881261198 1.5952762251209573 1.1207071271675502 0.8076211374198574 0.709367946702822 0.08797465321170271 0.27529019181814884 1.3817282432451414 0.043491619349937 0.10404977351397256 1.7195947825169748e-07 6.764573881261198 -0.31308598974769275 K(ub)LYDIDVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLYDIDVAK 9 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9;K7EMA7 P62750 RPL23A 60S ribosomal protein L23a 1 26561900.0 7712700.0 9151300.0 9697900.0 True False 9984242.190046038 8642022.110360784 7932981.708857047 1.0 0.8655661537313865 0.7945502080033645 23.25122149973232 -13.999999933492132 0.07988113934851147 1.7254194118246624 0.5820140984121642 0.9998871657660606 0.0009049637683030713 12.259733653049434 0.07948947121256965 1.5723376708288854 0.1930467553904166 1.0000001531400364e-14 13.999999933492132 -1.1434053134124982 K(ub)LYLEGNPLWFHPEHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLYLEGNPLWFHPEHR 16 1 Q8N1F8 Q8N1F8 STK11IP Serine/threonine-protein kinase 11-interacting protein 1 7856200.0 1833100.0 2593900.0 3429200.0 True False 1774909.2438882098 3629657.7970097996 2530989.646205144 1.0 2.0449821924745177 1.4259825706133709 20.759313826764114 -10.638766665775323 6.467284611364444 0.9966086431523286 1.7354823815439442 0.6530619858433429 0.2527055374225909 0.012382285986769884 0.0006916175938714955 0.2451823268969515 0.08156036149434079 2.2973826357400264e-11 10.638766665775323 0.7388737383916156 K(ub)LYLEGNPLWFHPEHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLYLEGNPLWFHPEHR 16 1 Q8N1F8 Q8N1F8 STK11IP Serine/threonine-protein kinase 11-interacting protein 1 20772000.0 5130200.0 6471300.0 9170500.0 True False 7782888.467858348 5316445.9545023255 7357946.655427068 1.0 0.6830941977979129 0.9454005008312533 22.891874252154626 -10.007442487283388 6.515361172303212 1.0000000633964026 0.814247350291701 0.4007089893718707 0.1070860997912635 9.865450134600926e-08 1.49396768091757e-08 0.10368570581122763 0.0345618900918215 9.830090422274867e-11 10.007442487283388 -0.18575271310470154 K(ub)LYLEGNPLWFHPEHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLYLEGNPLWFHPEHR 16 1 Q8N1F8 Q8N1F8 STK11IP Serine/threonine-protein kinase 11-interacting protein 1 7376000.0 1833100.0 3880400.0 1662500.0 True False 1524303.8700991622 3859495.5150009063 2010121.0634685073 1.0 2.531972522479937 1.3187141375805473 20.53971910219839 -6.587799489756252 2.2371253208098625 2.038291030276478 1.3221246925620433 0.0 0.6642265673113468 0.676076104422832 6.375506208313535 0.24817124161068224 0.7408195519939613 2.5834526745026653e-07 6.587799489756252 -0.7161663377144345 K(ub)LYLEGNPLWFHPEHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLYLEGNPLWFHPEHR 16 1 Q8N1F8 Q8N1F8 STK11IP Serine/threonine-protein kinase 11-interacting protein 1 15243000.0 5130200.0 5081700.0 5031100.0 True False 6641145.031360517 4798898.927826685 4115491.4234453584 1.0 0.7226011335643988 0.6196960620512532 22.663000574247075 -13.999999999999998 0.13774289496135256 2.322684647612833 0.48881494871624886 0.9996120831752378 0.0031633774013407534 11.932369510959326 0.1161103547883984 4.247848426111729 0.11683758039386737 1.0000000000000041e-14 13.999999999999998 -1.8338696988965841 K(ub)LYQTFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLYQTFK 7 1 O75665;O75665-3;O75665-2 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 5947960.0 526060.0 1109300.0 4312600.0 True False 509360.5132506856 1552249.27492308 3183000.6847732197 1.0 3.047447209868679 6.249013423635142 18.95832759748536 -6.964556966559339 0.3655762261638094 0.7411124926303501 8.66601980585663 0.9999037194859615 0.02119544933883167 0.07811162595743094 0.015392007519150453 0.04250466033387016 0.27256975480022705 1.0850332161109348e-07 6.964556966559339 7.92490731322628 K(ub)LYQTFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLYQTFK 7 1 O75665;O75665-3;O75665-2 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 5774560.0 526060.0 2560400.0 2688100.0 True False 437442.19840945135 2546606.61700039 3250169.2816298865 1.0 5.82158426018318 7.429939986237193 18.738732872919638 -9.084751020143226 0.4171983596131649 8.478698745263176e-17 7.6487029807854325 0.9975462930202829 0.13533359062284386 0.5193995820867128 0.1579169598584263 1.316900978109956 0.3862488302079733 8.227141745926989e-10 9.084751020143226 7.6487029807854325 K(ub)MAAGDIGELLVPHMPTIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KMAAGDIGELLVPHMPTIR 19 1 Q92995 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 26996700.0 6477900.0 12238600.0 8280200.0 True False 6272262.610323186 17125536.803455856 6111367.219324577 1.0 2.730360296979568 0.9743481099254677 22.580554533541253 -6.649459841897566 2.0097504860399256 2.123238873157248 0.9816121388440009 0.19221551632927125 0.7386191275298879 0.5098001252509116 3.9460306559982588 0.2980725890938699 0.8184554920757807 2.2415073026599355e-07 6.649459841897566 -1.1416267343132471 K(ub)MAAGDIGELLVPHMPTIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KMAAGDIGELLVPHMPTIR 19 1 Q92995 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 19943700.0 6477900.0 11507300.0 1958500.0 True False 5386660.869628149 11445307.890879788 2368013.2949191355 1.0 2.1247500386394065 0.43960690160964294 22.36095980897553 -6.726771030390765 1.7346163107202175 1.6792710425567525 0.44111271048371203 0.5444169065940347 0.47295000220878347 0.3423193660842565 2.0162610330237314 0.2161844024147487 0.5384984604138443 1.8759833070741716e-07 6.726771030390765 -1.2381583320730405 K(ub)MAQELYMEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KMAQELYMEQK 11 1 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 4057530.0 891240.0 2359240.0 807050.0 True False 1168424.270780437 2007250.5882454936 723544.2077702478 1.0 1.7179124385226705 0.6192478416140431 20.15613280091176 -6.730388491976256 1.721722699313748 1.43185314797286 0.6198485794227038 0.5610722906694383 0.3017851868574852 0.33552821536750943 1.9487059219203275 0.13889008106492592 0.3445067907935619 1.8604221777881547e-07 6.730388491976256 -0.8120045685501562 K(ub)MAQELYMEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KMAQELYMEQK 11 1 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 5577580.0 2414180.0 1679500.0 1483900.0 True False 2337543.177355318 2350133.1084767985 1095222.073954222 1.0 1.005385967302527 0.4685355481618738 21.15656158295807 -6.904636082126796 0.9315144471984163 1.0195708581930678 0.40656798773012 0.9887344519134551 0.026727339566921186 0.10807212032909025 0.15880779142923732 0.02131752744257428 0.05687132238645741 1.2455578921657862e-07 6.904636082126796 -0.6130028704629478 down K(ub)MAQELYMEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KMAQELYMEQK 11 1 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 6555650.0 2414180.0 2954500.0 1186970.0 True False 2007497.6363078887 2938583.522077667 1435159.9390708029 1.0 1.4638042251856371 0.7148999396633378 20.936966858392346 -6.739203142752145 1.689767892725582 1.2762173827435974 0.7145496552871522 0.6013043174256338 0.19487417064973436 0.31925457792460016 1.7895996603364739 0.09124886597456927 0.224099357181466 1.8230427682677656e-07 6.739203142752145 -0.5616677274564452 K(ub)MAQELYMEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KMAQELYMEQK 11 1 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 12217300.0 4241800.0 6237800.0 1737700.0 True False 5491093.718378434 5890660.946533114 1421456.4303076826 1.0 1.0727664193414415 0.2588658112955046 22.38866210378719 -6.8850836731939715 1.051007647041513 1.049023350290855 0.1952456916998452 0.9775612573147507 0.0550839282254446 0.12322364712996609 0.2458650504120329 0.04016912995478922 0.09852629185699602 1.3029157284671867e-07 6.8850836731939715 -0.8537776585910098 down K(ub)MFLGDAVDVFETR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KMFLGDAVDVFETR 14 1 Q5JRG1;H7BYF2;Q9BVL2-2;Q9BVL2-3;Q9BVL2 Q5JRG1 NUPL1 Nucleoporin p58/p45 1 13434400.0 1999000.0 4343900.0 7091500.0 True False 2587744.9061809788 4102158.146405014 5800919.764934651 1.0 1.5852250879160352 2.241689183148933 21.30326397617296 -6.969636832904902 0.2667162274513511 0.8301728875843448 3.0163905936012654 0.9999794103855082 0.002301431953375715 0.07642071194541135 0.00945093229498983 0.013131916348658526 0.06133523872714499 1.072415709219642e-07 6.969636832904902 2.1862177060169206 K(ub)MKDTDSEEEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KMKDTDSEEEIR 12 2 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 1 23712600.0 7273700.0 9311300.0 7127600.0 True False 9415948.03606232 8793117.969709467 5830449.935351937 1.0 0.9338537060774481 0.6192100798583196 23.166674927899123 -6.9409240557453264 0.6509150357901528 1.0034832418432775 0.5320047868365169 0.9982823789982039 0.0068849037138610444 0.08734774147431583 0.05270984248387378 0.006749791931478605 0.026972423533579846 1.1457132726423671e-07 6.9409240557453264 -0.47147845500676067 K(ub)MLQHYLQNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KMLQHYLQNK 10 1 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 2849180.0 509680.0 1156500.0 1183000.0 True False 668195.4157481407 983954.7080016911 1060594.5081372943 1.0 1.472555310634708 1.5872519971568595 19.349910559324435 -11.799521442274674 0.2395885539788745 1.3234235863937531e-11 1.6441879193312658 0.9993473898239883 0.006492566384947967 4.677382173828447 0.13936758619789374 2.4112814151410853 0.05597877167997131 1.5866405803485704e-12 11.799521442274674 1.6441879193180315 K(ub)MLQHYLQNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KMLQHYLQNK 10 1 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 5183610.0 833610.0 3258700.0 1091300.0 True False 693183.6501845852 3241144.736298695 1319485.7843989038 1.0 4.67573742605675 1.9035154450736727 19.40287810112792 -6.574316165867623 2.288687538849681 3.5115426102138954 1.9096260779213243 0.0 1.5991310659019768 0.7166892452846475 7.05258294029716 0.5887084567561651 1.790912809083003 2.6649179010998435e-07 6.574316165867623 -1.601916532292571 K(ub)MLVEATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KMLVEATR 8 1 Q9NYB0;A0A590UJT3 Q9NYB0 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 1 3702930.0 1422800.0 1456300.0 823830.0 True False 1377633.9928013445 2037808.1845041735 608044.2086297644 1.0 1.4792086977763959 0.4413684707309953 20.39376121577848 -6.781139836359377 1.5312740323330143 1.2709384367374488 0.4328287211294145 0.7714497443211839 0.20275389999663 0.24880933378232406 1.1523880417778565 0.10427662920439501 0.24583170243893246 1.6552369160061244e-07 6.781139836359377 -0.8381097156080343 down K(ub)MLVEATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KMLVEATR 8 1 Q9NYB0;A0A590UJT3 Q9NYB0 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 1 3347130.0 1450500.0 1046200.0 850430.0 True False 1986789.048288613 999975.4246792471 649575.9491556336 1.0 0.5033123297818705 0.3269476191824026 20.92200726871385 -13.999999999999966 0.14423386645459546 3.382954537557377 0.11943214715121059 0.9995866072188804 0.005793753765720544 11.940712129013335 0.11928011066290432 7.9914409984968415 0.18609417950710094 1.0000000000000778e-14 13.999999999999966 -3.2635223904061665 K(ub)MLVEATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KMLVEATR 8 1 Q9NYB0;A0A590UJT3 Q9NYB0 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 1 4339180.0 1422800.0 2487000.0 429380.0 True False 1183121.2407272311 2473602.0373691535 519161.3727711916 1.0 2.090742649374379 0.4388065693521636 20.174166491212755 -6.7285949497015105 1.7280637180347365 1.6573948926830882 0.4399691480627027 0.55295323721861 0.4585720595280392 0.33883287552686175 1.981549870565134 0.2103379257562211 0.5228292810262556 1.8681212057010016e-07 6.7285949497015105 -1.2174257446203853 K(ub)MLVEATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KMLVEATR 8 1 Q9NYB0;A0A590UJT3 Q9NYB0 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 1 5520200.0 1619100.0 2277900.0 1623200.0 True False 2095956.8672324289 2151132.862564972 1327794.2554384714 1.0 1.0263249669853176 0.6335026622908205 20.999177597234766 -6.890868887100705 1.017247159516477 1.020669301944347 0.599137856142259 0.9814479627015231 0.02442113062088264 0.1184402660686653 0.21776153542503235 0.018271279104466496 0.04569460010028414 1.2856747447745698e-07 6.890868887100705 -0.4215314458020879 K(ub)MNVSPDVNYEELAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KMNVSPDVNYEELAR 15 1 P17980;R4GNH3;E9PM69 P17980 PSMC3 26S protease regulatory subunit 6A 1 9659400.0 1961800.0 3593800.0 4103800.0 True False 2571938.798098224 3057619.048522684 3679178.1424292726 1.0 1.1888381833905175 1.4305076563834946 21.29442488200142 -6.967761377927904 0.3069854648708939 0.9614182668988028 1.6655761782581187 0.9999592789640356 0.0011243364215247297 0.07703598053838305 0.011616700742115247 0.0038769335628950213 0.021519262800930337 1.0770568374042624e-07 6.967761377927904 0.7041579113593158 K(ub)MNVSPDVNYEELAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KMNVSPDVNYEELAR 15 1 P17980;R4GNH3;E9PM69 P17980 PSMC3 26S protease regulatory subunit 6A 1 17413400.0 3314400.0 3557000.0 10542000.0 True False 3209186.1862108386 4977328.649509951 7780733.9467790285 1.0 1.5509628799028328 2.424519331477593 21.613776061695837 -6.964319449921331 0.3695455506343352 0.9324758306751462 3.0733918984972544 0.9998984228201917 0.005911139636184924 0.07819265853185095 0.015678836702767266 0.011522143558257017 0.07420875167923305 1.0856267855373069e-07 6.964319449921331 2.140916067822108 K(ub)MNVSPDVNYEELAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KMNVSPDVNYEELAR 15 1 P17980;R4GNH3;E9PM69 P17980 PSMC3 26S protease regulatory subunit 6A 1 18098000.0 4711000.0 0.0 13387000.0 True False 7146931.420233258 0.0 10741053.582269473 1.0 0.0 1.5028902546708518 22.768892514003806 -6.7273586812052875 1.7329809207369575 0.39642494974608006 1.5015492879661336 0.5468782795587481 0.42047223985869436 0.3412356189123118 2.006469032759262 0.19237609356386814 0.478780470628111 1.8734466006515695e-07 6.7273586812052875 1.1051243382200535 K(ub)MNVSPDVNYEELAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KMNVSPDVNYEELAR 15 1 P17980;R4GNH3;E9PM69 P17980 PSMC3 26S protease regulatory subunit 6A 1 13021400.0 1961800.0 5478900.0 5580700.0 True False 2687130.4756515687 5236824.081700559 4262653.598124297 1.0 1.9488536671933456 1.5863217795893219 21.35763494352431 -10.182726817797983 4.651567547061177 0.9998994316711978 1.7675877232977595 0.8566773197923994 0.14800302385451305 103866732.37983766 30.89932366050348 134836.21266993953 0.050665371635155894 6.565581280902345e-11 10.182726817797983 0.7676882916265617 K(ub)MNVSPDVNYEELAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KMNVSPDVNYEELAR 15 1 P17980;R4GNH3;E9PM69 P17980 PSMC3 26S protease regulatory subunit 6A 1 11616700.0 3314400.0 4193100.0 4109200.0 True False 2756070.4528158135 4170510.938034817 4968414.721205888 1.0 1.5132091176311921 1.8027168776218234 21.394181337130114 -9.865622830214052 0.12518059788274452 2.4370317007318876e-18 2.3885937734755065 0.9998564809146703 0.00397640877198717 1.4162237793185632 0.05646619963005173 0.7824921493190183 0.3174276094828953 1.3626275638106015e-10 9.865622830214052 2.3885937734755065 K(ub)MNVSPDVNYEELAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KMNVSPDVNYEELAR 15 1 P17980;R4GNH3;E9PM69 P17980 PSMC3 26S protease regulatory subunit 6A 1 10139400.0 2717900.0 3539200.0 3882300.0 True False 3518375.1278185477 3342240.408793166 3175761.235761938 1.0 0.9499386186445138 0.9026215569375526 21.746477879931515 -6.9718077561486975 0.2105798647701257 1.0245907001687669 0.826647702585556 0.999993238591342 0.00010322503460321193 0.07572032785705944 0.006890391229671716 0.0014104255784438814 0.0048966367296946305 1.067068362863762e-07 6.9718077561486975 -0.19794299758321088 K(ub)MPSNQNVSPSQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KMPSNQNVSPSQR 13 1 Q14094;D6RG12;D6RH01 Q14094 CCNI Cyclin-I 1 3891170.0 471990.0 880780.0 2538400.0 True False 618783.4607576611 749371.0572535493 2275750.718052161 1.0 1.2110392484246297 3.6777820713980436 19.239075110458106 -6.92377705847166 0.7962167191746197 0.9526196852447598 4.112301339883418 0.9951673557315537 0.08450743699877068 0.09599996889903603 0.09447070500940208 0.07430830018150714 0.23130226442938165 1.1918536793761969e-07 6.92377705847166 3.159681654638658 up K(ub)MPSNQNVSPSQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KMPSNQNVSPSQR 13 1 Q14094;D6RG12;D6RH01 Q14094 CCNI Cyclin-I 1 3752930.0 713430.0 1032100.0 2007400.0 True False 690782.5551618375 1444222.9123303965 1481601.7192908584 1.0 2.090705536117718 2.144816350991589 19.397872124328416 -10.893723121998226 0.5371776684302801 1.6766842199728766e-14 2.1407632022195244 0.9998237913531548 0.007000635519303672 2.608443454089938 0.26126306149471534 3.29876832345789 0.010307635971098655 1.2772528428909645e-11 10.893723121998226 2.1407632022195076 K(ub)MPSNQNVSPSQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KMPSNQNVSPSQR 13 1 Q14094;D6RG12;D6RH01 Q14094 CCNI Cyclin-I 1 5059400.0 1720000.0 2167700.0 1171700.0 True False 2609365.748843386 1780856.9986825972 940112.981425646 1.0 0.6824865389115998 0.3602840965634487 21.315267746925343 -7.183303971735257 0.2604722689253717 1.1011478557309726 4.916336274581854e-15 0.9999630653275094 0.0015871927246907244 0.08768224443858605 0.012700646669868379 0.010468752038692722 0.037528284110349384 6.556861772739101e-08 7.183303971735257 -1.1011478557309677 down K(ub)MPSNQNVSPSQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KMPSNQNVSPSQR 13 1 Q14094;D6RG12;D6RH01 Q14094 CCNI Cyclin-I 1 5449610.0 471990.0 940320.0 4037300.0 True False 646497.4580501491 898773.5531775862 3083772.8908035224 1.0 1.3902197788809678 4.769969088670899 19.302285171980998 -6.928649495781281 0.7577971107671674 0.9459460707046788 5.440536332705649 0.9962660633092769 0.10343512677688917 0.09334522039855986 0.0811606764655687 0.09348812450065447 0.30811147684994816 1.1785567626380977e-07 6.928649495781281 4.49459026200097 up K(ub)MPSNQNVSPSQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KMPSNQNVSPSQR 13 1 Q14094;D6RG12;D6RH01 Q14094 CCNI Cyclin-I 1 3881430.0 713430.0 1431900.0 1736100.0 True False 593248.6553078633 1424186.0704901032 2099110.483180552 1.0 2.400656213457457 3.538331632780911 19.178277399762692 -7.282682390737365 0.1785500164968865 3.1912397229259366e-15 5.618244399684718 0.9999885605056259 0.0035111639763676407 0.10774045092392631 0.01058791140882975 0.09503119047314695 0.21435904527797633 5.215760118577466e-08 7.282682390737365 5.6182443996847145 K(ub)MPSNQNVSPSQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KMPSNQNVSPSQR 13 1 Q14094;D6RG12;D6RH01 Q14094 CCNI Cyclin-I 1 6175300.0 1720000.0 1917200.0 2538100.0 True False 2226573.906268775 1810506.1346457556 2076191.8431052137 1.0 0.8131354317718323 0.9324603316601482 21.086394069017793 -10.6890873234285 5.165737919278339 1.0031506556573033 0.87279788171599 0.6024147100990631 0.048714186389177225 0.0018089176839462637 0.00010887413109185157 0.04826912313343781 0.015722436050777184 2.046033200234604e-11 10.6890873234285 -0.13035277394131328 K(ub)MQEAPESATVIFAGDTNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KMQEAPESATVIFAGDTNLR 20 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 14438700.0 3868200.0 3385000.0 7185500.0 True False 3745406.108345627 4736648.1525417995 5303401.989620634 1.0 1.264655424678103 1.4159751536164353 21.836690725586724 -11.54504691762825 0.08359299001518199 6.946747735827639e-18 1.9008691740470158 0.9999275034070244 0.0014637097589324654 4.596604785037567 0.05788151982890919 1.18831997375908 0.3397085930455616 2.850710283415438e-12 11.54504691762825 1.9008691740470158 K(ub)MQEAPESATVIFAGDTNLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KMQEAPESATVIFAGDTNLR 20 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 45028200.0 7004200.0 16952000.0 21072000.0 True False 10625883.475609804 13926783.15341945 16907109.9638143 1.0 1.310647080347379 1.591125105279213 23.34107946149883 -6.97233963908499 0.1943487507566218 0.8203791548820198 2.0890902346372395 0.999995342751046 0.0005209910907020112 0.07555065335657879 0.006232273252915248 0.009544240566540591 0.03021614411749998 1.0657623180593015e-07 6.97233963908499 1.2687110797552197 K(ub)MQEAPESATVIFAGDTNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KMQEAPESATVIFAGDTNLR 20 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 11179200.0 3868200.0 3395100.0 3915900.0 True False 3216579.6903156266 3376809.9224254144 4734696.584924101 1.0 1.0498138543224045 1.4719662003646827 21.617096001021 -6.929038432021569 0.7546340071373138 0.9933465074176308 1.5565499491274395 0.9963461217222283 0.012798188702509934 0.09313968716173164 0.08014583731522218 0.011593876444238604 0.038401280188954376 1.1775017682462283e-07 6.929038432021569 0.5632034417098087 K(ub)MQEAPESATVIFAGDTNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KMQEAPESATVIFAGDTNLR 20 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 31973600.0 7004200.0 9268400.0 15701000.0 True False 9067074.973423123 8752605.392421613 12843579.105864625 1.0 0.9653174169262673 1.4165074341516937 23.11220578359128 -6.888347333824316 1.0321408520374162 0.9747877097238833 1.4540759164229715 0.9798180819383168 0.029124037446142385 0.12049302062569657 0.22977798922627662 0.021545711995960767 0.0534024185893273 1.293161201814607e-07 6.888347333824316 0.4792882066990882 K(ub)MQQENMKPQEQLTLEPYER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KMQQENMKPQEQLTLEPYER 20 2 P22087;M0R299;M0QXL5 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 17856000.0 3430300.0 3135700.0 11290000.0 True False 4440590.971321971 2961195.53849817 9235335.84518257 1.0 0.6668471736356788 2.079753777104401 22.08232025821034 -6.844544730992013 1.2611450293374702 0.8227357549561751 2.1305587844068157 0.9319839452491078 0.15727813580312155 0.16355892524504928 0.5033496899998608 0.09770891283776605 0.2254508896160205 1.4303926472022647e-07 6.844544730992013 1.3078230294506406 up K(ub)MTFSEHPYNNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KMTFSEHPYNNLR 13 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-8;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 5965160.0 876840.0 989320.0 4099000.0 True False 849005.19415795 1384360.6352356435 3025348.932635862 1.0 1.6305679220356988 3.5634045038280675 19.695413854555518 -6.950965956790142 0.5481353316279746 0.9729692307444965 4.311515285570284 0.9992749308205199 0.02936648541892571 0.08310014847593443 0.034374779879824034 0.03195059527114572 0.16028958453787076 1.1195256367176744e-07 6.950965956790142 3.3385460548257875 K(ub)MTFSEHPYNNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KMTFSEHPYNNLR 13 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-8;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 3450340.0 876840.0 1474600.0 1098900.0 True False 729131.3105983031 1466656.0371148188 1328674.9092604741 1.0 2.011511528576828 1.8222710915681344 19.475819129989794 -10.227601074569689 4.710910369906984 0.9997893236677052 1.9168913100759806 0.9690404014016001 0.07725708490743717 0.0001709850638424284 2.8034610400826658e-05 0.07482063849669336 0.024934616933552745 5.921052685238009e-11 10.227601074569689 0.9171019864082753 K(ub)MYEEFLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KMYEEFLSK 9 1 P10644;P10644-2;K7EPB2;K7EM13;K7EKR1;P31321;H7BYW5;C9JSK5 P10644;P31321 PRKAR1A;PRKAR1B cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed;cAMP-dependent protein kinase type I-beta regulatory subunit 1 14864300.0 4166200.0 4994000.0 5704100.0 True False 5461928.545538192 4248914.666459532 5113894.449590817 1.0 0.7779147293917711 0.9362799983475285 22.380979009814777 -10.480591229493847 5.0702152144297745 1.000332296670321 0.8570973638696453 0.5205386217548217 0.06465235032005334 0.00024341126801429282 2.4935723393248448e-05 0.06274399779916452 0.02086645634022563 3.306806407729637e-11 10.480591229493847 -0.14323493280067567 K(ub)MYEEFLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KMYEEFLSK 9 1 P10644;P10644-2;K7EPB2;K7EM13;K7EKR1;P31321;H7BYW5;C9JSK5 P10644;P31321 PRKAR1A;PRKAR1B cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed;cAMP-dependent protein kinase type I-beta regulatory subunit 1 19877900.0 4206500.0 6686300.0 8985100.0 True False 4072966.960021682 9356174.45859387 6631632.762777859 1.0 2.2971397878818203 1.6282068643990564 21.957648680545883 -9.923797287532068 5.410792023105551 0.9999985533286478 1.962673325862649 0.7341425091647464 0.2730907224621482 42801474.07813331 78501108.40082845 490.0496416603021 0.09348621381642315 1.1917981651581312e-10 9.923797287532068 0.9626747725340011 K(ub)MYEEFLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KMYEEFLSK 9 1 P10644;P10644-2;K7EPB2;K7EM13;K7EKR1;P31321;H7BYW5;C9JSK5 P10644;P31321 PRKAR1A;PRKAR1B cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed;cAMP-dependent protein kinase type I-beta regulatory subunit 1 34577200.0 7749200.0 16380000.0 10448000.0 True False 11756102.94240534 13456861.022475874 8382948.220478926 1.0 1.1446702268943005 0.713072032590057 23.48690656133889 -6.816311075188681 1.3877127633140374 1.07828036705527 0.7043717959591038 0.8756903424596639 0.06323842786155946 0.198324376752763 0.7514217766922361 0.0358185644393397 0.08265002987675034 1.5264722894311812e-07 6.816311075188681 -0.37390857109616626 K(ub)MYEEFLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KMYEEFLSK 9 1 P10644;P10644-2;K7EPB2;K7EM13;K7EKR1;P31321;H7BYW5;C9JSK5 P10644;P31321 PRKAR1A;PRKAR1B cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed;cAMP-dependent protein kinase type I-beta regulatory subunit 1 14459600.0 4166200.0 5050300.0 5243100.0 True False 5706556.727321627 4827161.046891228 4004787.765034042 1.0 0.8458973208449743 0.7017870769355673 22.444189071337668 -6.971933372248115 0.2068614906463182 1.0785377779115544 0.46513769788984677 0.9999937914682413 0.0003033527240373857 0.07568022389259861 0.006736710375552579 0.004424949985225138 0.01504367502243958 1.0667597667662157e-07 6.971933372248115 -0.6134000800217076 K(ub)MYEEFLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KMYEEFLSK 9 1 P10644;P10644-2;K7EPB2;K7EM13;K7EKR1;P31321;H7BYW5;C9JSK5 P10644;P31321 PRKAR1A;PRKAR1B cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed;cAMP-dependent protein kinase type I-beta regulatory subunit 1 17257400.0 4206500.0 8675000.0 4375900.0 True False 3497891.129546734 8628266.05314731 5290880.458124406 1.0 2.466705147071111 1.5125915193392574 21.73805395598016 -10.53540219894867 5.328322082615962 0.9966890381715104 1.9896483332051875 0.5892379145434419 0.38951525742981635 0.015346176291086575 0.001338093671161668 0.37778041166189635 0.12571550875994592 2.914726443398564e-11 10.53540219894867 0.9929592950336771 K(ub)MYEEFLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KMYEEFLSK 9 1 P10644;P10644-2;K7EPB2;K7EM13;K7EKR1;P31321;H7BYW5;C9JSK5 P10644;P31321 PRKAR1A;PRKAR1B cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed;cAMP-dependent protein kinase type I-beta regulatory subunit 1 31531400.0 7749200.0 18002000.0 5780200.0 True False 10031492.15956861 17000172.8749702 4728262.90986043 1.0 1.6946803730245124 0.4713419334480906 23.25803288343134 -6.752646353970685 1.6398952799968218 1.4071723287161366 0.4683870778859113 0.6603458236961379 0.2919567574139167 0.29544943076912944 1.564004117814673 0.14058792289862654 0.34038745599778236 1.7674764910917396e-07 6.752646353970685 -0.9387852508302253 K(ub)NCHLNENIEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KNCHLNENIEK 11 1 Q13907;Q13907-2 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 1 11338500.0 3892700.0 5480200.0 1965600.0 True False 5103367.396960425 4662575.521652293 1762218.567366581 1.0 0.9136272502013733 0.3453050565037041 22.2830180759679 -6.933915810635047 0.7139222132033218 1.0075145201856999 0.21607760133059759 0.9972533549168943 0.01522027746741581 0.09065510905746767 0.06809017039807552 0.014204793255219545 0.050362183713511935 1.1643517208141972e-07 6.933915810635047 -0.7914369188551023 down K(ub)NCHLNENIEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KNCHLNENIEK 11 1 Q13907;Q13907-2 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 1 13255100.0 3892700.0 5526700.0 3835700.0 True False 5331936.386262038 5282512.119647102 2929786.6587211946 1.0 0.9907305220778179 0.5494789221923043 22.34622813749079 -6.91143802439738 0.8858886853612403 1.013048499933561 0.49066583654667784 0.9914529359425803 0.019435545892978953 0.1034746587905317 0.13366733517462315 0.016026154648576707 0.04469265484667998 1.2262018742263618e-07 6.91143802439738 -0.5223826633868831 K(ub)NCPHVVVGTPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KNCPHVVVGTPGR 13 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 1 7993300.0 3026800.0 2810000.0 2156500.0 True False 3968164.1115728994 2390758.95329421 1933366.0666086855 1.0 0.6024848988280784 0.48721928132209696 21.920040261897853 -13.999999999999998 0.17358561086674468 3.0241912591798035 0.38932805342969307 0.999507295596412 0.004875743137792725 12.12846727083477 0.13199939538258776 8.270231162370571 0.0909934052113604 1.0000000000000041e-14 13.999999999999998 -2.6348632057501105 K(ub)NCPHVVVGTPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KNCPHVVVGTPGR 13 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 1 34379600.0 5084300.0 9334300.0 19961000.0 True False 7713254.812118866 7668521.235781222 16015699.600782886 1.0 0.9942004280388405 2.076386686411479 22.87890834132256 -6.905693095967409 0.9245663635699247 0.9617607944907026 2.2040851449415433 0.9891922239757285 0.05289362656869373 0.10733543733010603 0.15472615298419196 0.04240292310208206 0.11383633184117435 1.2425300594245998e-07 6.905693095967409 1.2423243504508408 up K(ub)NCPHVVVGTPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KNCPHVVVGTPGR 13 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 1 9947500.0 3026800.0 3677000.0 3243700.0 True False 4145889.756194402 3514537.981787033 2477604.86609848 1.0 0.8477162173779315 0.5976051009066687 21.983250323420744 -6.963706219938956 0.3796020339497152 1.0172572764613406 0.4192250492483566 0.9998839409696383 0.0017871068717602507 0.07840277721061625 0.016425076116793797 0.0032562971314751715 0.021138198736744232 1.087160788754051e-07 6.963706219938956 -0.598032227212984 K(ub)NCPHVVVGTPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KNCPHVVVGTPGR 13 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 1 32034500.0 5084300.0 5374200.0 21576000.0 True False 6581726.576536251 5075121.045698521 17649389.38845518 1.0 0.7710926588459699 2.6815743837452874 22.65003466341501 -6.8769797659849345 1.0965464223141577 0.8630864579386547 2.8093438345068824 0.9711646105348181 0.1446436227229352 0.1303370450662373 0.28876257295018076 0.10187564781772494 0.24457033843786166 1.3274563031969533e-07 6.8769797659849345 1.9462573765682278 up K(ub)NDPQSITADDLHQLLVVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KNDPQSITADDLHQLLVVAR 20 1 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 1 5141800.0 1376000.0 2553700.0 1212100.0 True False 1803949.325202955 2172697.9142446336 1086683.5192842039 1.0 1.2044118334644418 0.6023913776857038 20.782727381695057 -6.81510073428051 1.3930895181025633 1.110749289878013 0.5905944120624497 0.8727113815197902 0.08917839971982067 0.19992233922721148 0.7636781263020823 0.050322646000741524 0.11615564808677688 1.5307323682729585e-07 6.81510073428051 -0.5201548778155632 K(ub)NFDLRPGVIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KNFDLRPGVIVR 12 2 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 26758200.0 6241800.0 13715000.0 6801400.0 True False 8183060.2456771815 11668775.460651282 6097656.37163566 1.0 1.425967194463157 0.7451559915933448 22.964209042761766 -6.737551266147254 1.6958121800744408 1.2541654764294168 0.7449773561121542 0.5938512799708962 0.1789860098812387 0.32225642713474106 1.8187150400315066 0.0835329902208873 0.20552411773044707 1.829990072992756e-07 6.737551266147254 -0.5091881203172626 K(ub)NFDLRPGVIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KNFDLRPGVIVR 12 2 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 31791900.0 9943900.0 11225000.0 10623000.0 True False 9628236.337515663 15707201.037601711 7840517.6168311285 1.0 1.6313684549266663 0.8143254218097212 23.198840124387218 -6.700384361229967 1.8297935553912659 1.3919106038140887 0.8167608997217757 0.41930197112719825 0.26648981187891607 0.3947049458115158 2.5695806487154735 0.11618423611859548 0.29862084594371613 1.9934972402413636e-07 6.700384361229967 -0.575149704092313 K(ub)NFDLRPGVIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KNFDLRPGVIVR 12 2 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 29821900.0 9943900.0 12434000.0 7444000.0 True False 8268793.439462687 12367015.574044233 9000505.98283282 1.0 1.4956251676360477 1.088490847997006 22.979245399821494 -9.957246819262505 5.781755386094891 0.9999997267721044 1.2920580078166892 0.4069232174926428 0.16621188998238232 5.857238940685184e-07 1.053519658814587e-07 0.1609341191409375 0.05364465682020155 1.1034513256108182e-10 9.957246819262505 0.29205828104458487 K(ub)NGFVVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KNGFVVLK 8 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 10755100.0 3389700.0 4380600.0 2984800.0 True False 4443929.525901492 3727031.5554450606 2675961.5282233274 1.0 0.838679266563976 0.6021611082323552 22.08340450723961 -6.965634195431822 0.34700040054805903 1.0236600836321446 0.4092359829798136 0.999925621849752 0.0014090336077238154 0.07774645275994402 0.014105102566276326 0.003272193791592988 0.020370476100233827 1.0823452226731824e-07 6.965634195431822 -0.614424100652331 K(ub)NGFVVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KNGFVVLK 8 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 18194600.0 6068300.0 5020100.0 7106200.0 True False 5875665.138119481 7024652.109475663 5244873.038569643 1.0 1.1955501112379454 0.8926432863817485 22.486320746474238 -6.732385027660636 1.7144956674364744 1.1173624764278594 0.8927404910679779 0.5703986512654647 0.08218965938998102 0.3317375941568149 1.9114427983602615 0.03797244976179155 0.09397407269922851 1.8518890865721365e-07 6.732385027660636 -0.22462198535988143 K(ub)NGFVVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KNGFVVLK 8 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 24722300.0 4810600.0 4887700.0 15024000.0 True False 7298031.901968604 4015451.7472255994 12054499.81474687 1.0 0.5502102212162779 1.6517466594651682 22.799076026729345 -6.79583366253958 1.4728053226320126 0.750504830348767 1.6654436298804087 0.8197171806205819 0.19200827341930224 0.22675936150731513 0.9714498955612012 0.102581475718968 0.23920357033303435 1.6001707865252752e-07 6.79583366253958 0.9149387995316417 K(ub)NGFVVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KNGFVVLK 8 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 8975800.0 3389700.0 3509100.0 2077000.0 True False 4642963.693198144 3354056.358958086 1586455.3771577342 1.0 0.7223955603770317 0.34169023968071555 22.1466145687625 -6.966703967435234 0.32749177854357003 1.0477596525203317 0.003909761236452372 0.9999440835524669 0.0020178592176082664 0.07738738669382561 0.012846155117501456 0.005605826961020521 0.033273958566567285 1.0796824263719768e-07 6.966703967435234 -1.0438498912838792 down K(ub)NGFVVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KNGFVVLK 8 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 17323300.0 6068300.0 8848500.0 2406500.0 True False 5046060.321271475 8800831.374210272 2909688.023601175 1.0 1.744099518016204 0.5766256917967262 22.266726021908514 -6.734539395867401 1.706868094904106 1.445519414764257 0.5767481237276912 0.5801083759373921 0.31270528646024065 0.3277869116822475 1.8728755724638388 0.14506975843651512 0.358119609152998 1.8427253234681359e-07 6.734539395867401 -0.8687712910365657 K(ub)NGFVVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KNGFVVLK 8 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 19900700.0 4810600.0 4506100.0 10584000.0 True False 6227416.531102661 4255331.573819755 8657820.60101083 1.0 0.6833221372886522 1.390274852785193 22.570202348821795 -6.7849166848511215 1.5163964566687642 0.8218285468835455 1.3967931404845233 0.7844663829116536 0.13423176463153524 0.24302964643180355 1.1039835616943963 0.06969475875574964 0.1638098582902728 1.6409045344932502e-07 6.7849166848511215 0.5749645936009778 K(ub)NIILEEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KNIILEEGK 9 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 1 6042900.0 2452200.0 2262200.0 1328500.0 True False 3214857.947138581 1924688.577986536 1191039.5638718482 1.0 0.5986854192732297 0.37047968633635764 21.616323560847412 -9.404015143889039 0.14874777750528675 1.5783925854927359 5.966523631611114e-09 0.9998055479972283 0.0036286516511820034 0.8426346764104233 0.05661034642375224 0.392406046943325 0.18491088683480414 3.944435475522233e-10 9.404015143889039 -1.5783925795262121 K(ub)NIILEEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KNIILEEGK 9 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 1 7777400.0 2612600.0 2618900.0 2545900.0 True False 2529664.4430649346 3664640.4273830843 1879052.4146371416 1.0 1.4486666156176098 0.7428069836647926 21.270514595179414 -6.734981139904284 1.7052267683527735 1.268497355030956 0.7428419521428646 0.5821447904802739 0.18854608507424883 0.32697039144826756 1.8647999004800755 0.08754703972896864 0.2160146028458976 1.8408519423648838e-07 6.734981139904284 -0.5256554028880913 K(ub)NIILEEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KNIILEEGK 9 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 1 8653900.0 2927600.0 3252900.0 2473400.0 True False 4441383.236229009 2672394.5799762974 1984531.405870271 1.0 0.6017032167314872 0.44682732840574524 22.082577632669842 -13.999999999970928 0.13066806038556725 2.892997687541456 0.23176331609257275 0.9996426023052354 0.004404969644213544 11.93574173242289 0.1124772239816606 5.7994934179275885 0.19131147692605813 1.0000000000669404e-14 13.999999999970928 -2.661234371448883 K(ub)NIILEEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KNIILEEGK 9 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 1 6321300.0 2452200.0 2300000.0 1569100.0 True False 3358844.6082132636 2198378.394917098 1198510.8966288874 1.0 0.6545043463878862 0.35682237091237007 21.679533622370304 -7.470960040516686 0.23198567627324546 1.1514436943635002 2.9652203570626934e-15 0.999914398350443 0.002431614891090528 0.1252403187827554 0.021151404980273878 0.026586829864422668 0.06275013091960226 3.380959430200006e-08 7.470960040516686 -1.1514436943634974 down K(ub)NIILEEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KNIILEEGK 9 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 1 7297510.0 2612600.0 3864000.0 820910.0 True False 2172492.6578043024 3843183.8650560523 992558.4855410106 1.0 1.769020415903401 0.45687541542449717 21.05091987061369 -6.747861352136986 1.657779487636417 1.4533499441356923 0.45468951595193385 0.6397180891516712 0.3231187758664366 0.30378571680414607 1.6419413643456757 0.15401620061968424 0.37475027372438724 1.7870579993838945e-07 6.747861352136986 -0.9986604281837584 K(ub)NIILEEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KNIILEEGK 9 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 1 7460700.0 2927600.0 2404000.0 2129100.0 True False 3789835.911623527 2270215.286714163 1741625.6464108254 1.0 0.5990273298512352 0.4595517291577753 21.85370395476229 -13.99999999999999 0.14726513069551095 2.9311709903424634 0.30116889317810286 0.999575623143634 0.0047192283255179475 11.948486453088133 0.12071024313171529 6.608740743737843 0.14239594722163762 1.0000000000000246e-14 13.99999999999999 -2.6300020971643607 K(ub)NILLTIGSYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KNILLTIGSYK 11 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 3303400.0 1064900.0 2238500.0 0.0 True False 1396094.2125062705 1904524.5256046578 0.0 1.0 1.3641805177214026 0.0 20.412964871422847 -6.8661251651157755 1.3700050023436678 1.1915206491815151 3.254841485586574e-22 0.9157873179012462 0.16736534446009274 0.1601173540040399 0.6042488381639072 0.09868435580198828 0.20439940814513416 1.3610523661113514e-07 6.8661251651157755 -1.1915206491815151 down K(ub)NLQEEIDALESR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KNLQEEIDALESR 13 1 E9PQY2;Q9NQP4 E9PQY2 PFDN4 Prefoldin subunit 4 1 9216100.0 5351400.0 1731700.0 2133000.0 True False 7329957.196147316 1655187.768033885 1629229.3305139367 1.0 0.2258113824871808 0.22226996514662767 22.805373342978445 K(ub)NLQYYDISAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KNLQYYDISAK 11 1 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 1 13773000.0 7158100.0 6614900.0 0.0 True False 6930870.033645846 9256264.06624778 0.0 1.0 1.3355125722042587 0.0 22.72460503488156 -6.873342228458531 1.3542286946318272 1.175738642521103 4.0952932201609733e-20 0.923668994199232 0.1567258744784088 0.15413921789853946 0.5683473746451989 0.09369078257156617 0.19240766711999394 1.3386214244361055e-07 6.873342228458531 -1.175738642521103 down K(ub)NLQYYDISAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KNLQYYDISAK 11 1 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 1 17060000.0 7158100.0 9901900.0 0.0 True False 5952277.307597413 9848556.49932673 0.0 1.0 1.6545863020790639 0.0 22.505010310315836 -6.813404556715983 1.4933619174041546 1.3605926021683352 2.5096746491046357e-18 0.829779962157339 0.28070552934508075 0.2134108800228168 0.9520393148332866 0.14984962582954198 0.33192633682676714 1.5367224760111673e-07 6.813404556715983 -1.3605926021683352 K(ub)NLTQDEMQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KNLTQDEMQR 10 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 2299340.0 701520.0 423520.0 1174300.0 True False 908131.4690265545 399950.73969599925 960589.4493355096 1.0 0.44041061601434756 1.0577647423287577 19.79254164418082 -6.668077329181951 1.9444914889256073 0.6422157774134365 1.0552310325947702 0.2703869859151947 0.23780952815818002 0.4655736392321595 3.392021469314831 0.0985294631381505 0.2638786915398363 2.1474480718790907e-07 6.668077329181951 0.41301525518133375 K(ub)NNPWLCTE ddPTM_RPMI8226_Bortezomib_1h_R1 1 KNNPWLCTE 9 1 Q14141 Q14141 SEPT6 Septin-6 1 7026600.0 2655200.0 3243900.0 1127500.0 True False 3480992.912993375 2759922.764623166 1010837.1157437004 1.0 0.7928550369411277 0.29038758222419403 21.731067446183896 -6.956105513590305 0.4872344652776317 1.011276778346976 0.05075878952394209 0.9995973624876439 0.005978478429525742 0.08112287184482726 0.026503990658948828 0.007191839604047421 0.04144255090269296 1.1063549579380662e-07 6.956105513590305 -0.960517988823034 down K(ub)NNPWLCTE ddPTM_RPMI8226_Bortezomib_2h_R1 1 KNNPWLCTE 9 1 Q14141 Q14141 SEPT6 Septin-6 1 11214000.0 6432900.0 2881000.0 1900100.0 True False 6228691.110691437 4031398.324216528 1402406.80822186 1.0 0.6472304136733807 0.22515273005184894 22.57049759830281 -7.408329628955631 0.37649018847425386 1.0431000261037433 2.33019295832228e-15 0.9993894140474598 0.00782694203667439 0.11404769695196637 0.036983685726096414 0.015805237739385292 0.05973703986308854 3.9054436060213554e-08 7.408329628955631 -1.043100026103741 down K(ub)NNPWLCTE ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KNNPWLCTE 9 1 Q14141 Q14141 SEPT6 Septin-6 1 11281700.0 6432900.0 3167800.0 1681000.0 True False 5349241.375790141 3150734.4326409297 2032489.327934167 1.0 0.5890058442493693 0.37995842497085797 22.350902873737088 -11.067403224937834 0.12401701699580729 2.0188496752906113 3.835902232180172e-19 0.9997903337788997 0.003729533956304084 3.391866244408035 0.07446113054932889 1.2342773033570553 0.25552018764981216 8.56242489388218e-12 11.067403224937834 -2.0188496752906113 K(ub)NPDSQYGELIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KNPDSQYGELIEK 13 1 P30085;P30085-3;Q5T0D2 P30085 CMPK1 UMP-CMP kinase 1 20979150.0 7283000.0 6346650.0 7349500.0 True False 7051805.151512639 8880900.44234253 5424445.469726097 1.0 1.2593797264006283 0.769227928619459 22.749561181414197 -6.762941087335307 1.6015188906122229 1.150110146335401 0.7671793435632132 0.7028240234724291 0.10914610736157208 0.2779986205895302 1.405952886182944 0.053757138688658376 0.12880833350720183 1.726072020236558e-07 6.762941087335307 -0.38293080277218794 K(ub)NPDSQYGELIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KNPDSQYGELIEK 13 1 P30085;P30085-3;Q5T0D2 P30085 CMPK1 UMP-CMP kinase 1 38027000.0 10335200.0 9233800.0 18458000.0 True False 15679254.004329162 7585956.245991306 14809768.20957122 1.0 0.48382124837678925 0.9445454615048733 23.90235358400538 -10.354982608670193 8.507161130537346 1.0000009307234088 0.7141833549408316 0.3391204655271087 0.18808987238484878 3.3203517854051942e-06 2.516902204474909e-07 0.18211783008787735 0.060705745278066436 4.415881304033345e-11 10.354982608670193 -0.28581757578257716 K(ub)NPDSQYGELIEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KNPDSQYGELIEK 13 1 P30085;P30085-3;Q5T0D2 P30085 CMPK1 UMP-CMP kinase 1 14857400.0 5874400.0 4893300.0 4089700.0 True False 8046324.429690878 4677097.8260208 3123797.0900153997 1.0 0.581271345306727 0.38822658933420723 22.93989847826336 -13.999999999999998 0.10386604738585362 3.0465176569719516 0.0006374226239391267 0.999774227343686 0.0038369279822822815 12.052177710885182 0.09673764763744162 5.238033288859087 0.34499647778004305 1.0000000000000041e-14 13.999999999999998 -3.0458802343480125 K(ub)NPDSQYGELIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KNPDSQYGELIEK 13 1 P30085;P30085-3;Q5T0D2 P30085 CMPK1 UMP-CMP kinase 1 16410300.0 7283000.0 9127300.0 0.0 True False 6056137.191605578 9078129.423272798 0.0 1.0 1.4989966600915197 0.0 22.529966456848474 -6.837842404782817 1.4343976248197894 1.268325593193553 4.351613585158075e-22 0.8765368389622153 0.21899411709018807 0.18654393928849233 0.7704475265470786 0.1223792774702221 0.26253111442296506 1.4526386502388255e-07 6.837842404782817 -1.268325593193553 down K(ub)NPDSQYGELIEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KNPDSQYGELIEK 13 1 P30085;P30085-3;Q5T0D2 P30085 CMPK1 UMP-CMP kinase 1 27648600.0 10335200.0 14688700.0 2624700.0 True False 13379120.137249444 13871260.932594972 2147031.531696254 1.0 1.0367842421846063 0.16047628765352076 23.67347990609783 -6.897102840247219 0.9794176015114295 1.0393860465123719 0.0737233807856024 0.9850684946257574 0.04945263226784929 0.11356881362299012 0.18969774491834776 0.03806653695275771 0.09767698911877867 1.2673517234366678e-07 6.897102840247219 -0.9656626657267695 down K(ub)NPEDQTMPQNR ddPTM_RPMI8226_Bortezomib_1h_R1 2 KNPEDQTMPQNR 12 1 Q96PZ2;E9PR18;E9PNQ0 Q96PZ2 FAM111A Protein FAM111A 1 6793330.0 1684410.0 2254160.0 2854760.0 True False 2208277.821849642 1917848.1146468616 2559376.8199915625 1.0 0.8684813548688733 1.158992222205013 21.074490257287504 -6.783663127532813 1.5219384469885697 0.9258837739414404 1.1615490430661919 0.7800168297408123 0.05570932168901511 0.24493120625254916 1.120830761700926 0.0288256935052577 0.06780155871952022 1.6456477202142166e-07 6.783663127532813 0.2356652691247515 K(ub)NPEDQTMPQNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KNPEDQTMPQNR 12 1 Q96PZ2;E9PR18;E9PNQ0 Q96PZ2 FAM111A Protein FAM111A 1 4790680.0 968880.0 1159800.0 2662000.0 True False 938123.4347380991 1622914.1882770997 1964742.3417117978 1.0 1.7299580504885024 2.094332439590218 19.839418234030934 -9.875085245443113 0.16813744941081202 2.9027141873383276e-13 2.549984834118412 0.9996396359434367 0.008637254822668356 1.3897013717522626 0.0752774939443434 0.9079180509207136 0.2725903849091463 1.3332597077474026e-10 9.875085245443113 2.5499848341181215 K(ub)NPEDQTMPQNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KNPEDQTMPQNR 12 1 Q96PZ2;E9PR18;E9PNQ0 Q96PZ2 FAM111A Protein FAM111A 1 9351800.0 2340400.0 3505900.0 3505500.0 True False 3550557.906158761 2880244.7532782764 2812636.3884847676 1.0 0.8112090633086799 0.7921674460247494 21.759614305267792 -13.999999999999998 0.3242354130157419 2.9852343251951368 0.7885632527757299 0.9997027507194101 0.0016173207397959116 18.34770431371096 0.18178834218135975 24.76423766659217 0.006236406524882752 1.0000000000000041e-14 13.999999999999998 -2.1966710724194067 K(ub)NPEDQTMPQNR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 KNPEDQTMPQNR 12 1 Q96PZ2;E9PR18;E9PNQ0 Q96PZ2 FAM111A Protein FAM111A 1 5776000.0 1684410.0 2019460.0 2072130.0 True False 2307181.89646868 1930233.5797388202 1582735.5708569344 1.0 0.8366195932332825 0.6860038097903912 21.137700318810396 -6.9721006470065845 0.20181493375789217 1.0875772971748467 0.43087947774200364 0.9999944606429227 0.00030173002591612927 0.07562687203503751 0.006530937814727248 0.004817737664138813 0.015917042227494547 1.0663489680353312e-07 6.9721006470065845 -0.6566978194328431 K(ub)NPEDQTMPQNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KNPEDQTMPQNR 12 1 Q96PZ2;E9PR18;E9PNQ0 Q96PZ2 FAM111A Protein FAM111A 1 8289100.0 2340400.0 2755100.0 3193600.0 True False 3029693.9361810754 2601776.2630724576 2612397.5691031916 1.0 0.8587587782388318 0.8622645138855559 21.53074062736024 -10.364926929279724 8.168608909444913 1.0000009054707084 0.8605116460621994 0.9995264726563347 0.001431210584593328 2.360145300116672e-08 1.8340207299851643e-09 0.0013857726822625598 0.0004619212299204824 4.3159168669002173e-11 10.364926929279724 -0.13948925940850898 K(ub)NVFIIGATNRPDIIDPAILRPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KNVFIIGATNRPDIIDPAILRPGR 24 3 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 5681100.0 2643200.0 1853000.0 1184900.0 True False 2197937.9136141557 1843017.521208298 1432657.1116414024 1.0 0.8385211928838117 0.6518187355372691 21.067719203570352 -6.969222604596836 0.27613117285363004 1.043095237042429 0.4415854121186822 0.9999756630997162 0.0007018224408201121 0.07655583921742279 0.009930034268500743 0.0035273175760704343 0.017222241479801136 1.0734390629131247e-07 6.969222604596836 -0.6015098249237467 K(ub)NVLVIGTTGSQTTFLPEGELPECAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KNVLVIGTTGSQTTFLPEGELPECAR 26 1 Q5TDH0;Q5TDH0-3 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 38980100.0 24671000.0 9424100.0 4885000.0 True False 23887832.60922266 13187192.27603225 3605471.9531412995 1.0 0.5520464117343535 0.1509334066477547 24.509772625340396 -7.85001523649221 0.38379488087973934 1.0599426785682877 3.84832855293225e-24 0.9981810410859369 0.014791006175128985 0.110212137522624 0.07111270664781946 0.037794198363761584 0.08064027998089765 1.4124879889855952e-08 7.85001523649221 -1.0599426785682877 down K(ub)NVLVIGTTGSQTTFLPEGELPECAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KNVLVIGTTGSQTTFLPEGELPECAR 26 1 Q5TDH0;Q5TDH0-3 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 77529000.0 30267000.0 21983000.0 25279000.0 True False 45917251.81409466 18059961.896037042 20282594.569820702 1.0 0.39331539198287546 0.4417205683811155 25.45253296230478 -10.084944404075303 7.828664164177528 1.0000000399596334 0.4175179823352662 0.994847283067386 0.019761330514183308 1.3796480541979965e-08 1.6024593091859913e-09 0.019133827420654306 0.006377941998361072 8.223479155409494e-11 10.084944404075303 -0.5824820576243672 K(ub)NVLVIGTTGSQTTFLPEGELPECAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KNVLVIGTTGSQTTFLPEGELPECAR 26 1 Q5TDH0;Q5TDH0-3 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 12116700.0 3917400.0 3722500.0 4476800.0 True False 5365768.643754436 3558027.6413386553 3419472.042590152 1.0 0.6630974754157679 0.6372753410772372 22.35535342047427 -13.999999999999998 0.36428692976599053 5.527659408978706 0.6343544866716347 0.9997809594795514 0.0024455528362449306 22.1674353638987 0.19541528912888675 78.1803223626435 0.007348688478727175 1.0000000000000041e-14 13.999999999999998 -4.893304922307071 K(ub)NVLVIGTTGSQTTFLPEGELPECAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KNVLVIGTTGSQTTFLPEGELPECAR 26 1 Q5TDH0;Q5TDH0-3 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 38378800.0 24671000.0 6801000.0 6906800.0 True False 20515029.610613964 6764361.663107188 8350979.946564965 1.0 0.3297271216029577 0.4070664339789388 24.290177900774673 -10.523914374432282 6.279254547876886 1.0006471150605387 0.36839677779473134 0.9888796955717721 0.03157364206314502 0.0002863008265042343 2.170692498098555e-05 0.03059967694061434 0.010190349157472882 2.9928546501318246e-11 10.523914374432282 -0.6322503372658074 K(ub)NVLVIGTTGSQTTFLPEGELPECAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KNVLVIGTTGSQTTFLPEGELPECAR 26 1 Q5TDH0;Q5TDH0-3 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 73969000.0 30267000.0 27588000.0 16114000.0 True False 39181228.15176574 26052703.54819899 13181417.343602488 1.0 0.6649282010070147 0.33642175004175956 25.22365928439723 -7.31331853553651 0.2668449719668032 1.1034261315597416 5.3689022205423806e-14 0.9999157369859031 0.0024868003935047864 0.10710501368286166 0.018310220018174075 0.015442594354273108 0.049158600377081425 4.8605057860882934e-08 7.31331853553651 -1.1034261315596878 down K(ub)NYEDEDSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KNYEDEDSLK 10 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 4211100.0 1069300.0 0.0 3141800.0 True False 1622206.2763013 0.0 2520821.8529001432 1.0 0.0 1.5539465539781572 20.62952585057815 -6.732899877953002 1.7123973069921679 0.40017990983808394 1.5535780944095203 0.5728259465390548 0.4202874425849326 0.3307991334949383 1.9015555974596674 0.19438737431698322 0.4808313494089743 1.8496949976483828e-07 6.732899877953002 1.1533981845714365 K(ub)NYEDEDSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KNYEDEDSLK 10 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 8603500.0 1069300.0 1165000.0 6369200.0 True False 1384229.9290541885 1100166.7258826958 5210070.953510788 1.0 0.7947861137740415 3.7638768272195255 20.4006521726706 -6.8903355478133275 1.0204345368514423 0.8417473658002326 4.020894120747401 0.9811108068958294 0.18607285983211505 0.11886976798863996 0.2202799003428504 0.13888171662900828 0.3466423949206694 1.2872545992137995e-07 6.8903355478133275 3.179146754947168 up K(ub)PAEQAEETAPIEATATKEEEGSS ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPAEQAEETAPIEATATKEEEGSS 24 2 Q8N4Q1;Q8N4Q1-2 Q8N4Q1 CHCHD4 Mitochondrial intermembrane space import and assembly protein 40 1 24738300.0 7285700.0 9515100.0 7937500.0 True False 11052939.556016425 7817056.06318437 6368649.645870167 1.0 0.7072377464445038 0.5761951029944367 23.397926773095282 -13.999999999998233 0.10869754695691441 2.415957696323196 0.33123128648083816 0.9997496810387353 0.0028030326790748905 12.020398498799937 0.09982947609487862 3.7445836594178283 0.21765423959664706 1.0000000000040697e-14 13.999999999998233 -2.084726409842358 K(ub)PAEQAEETAPIEATATKEEEGSS ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPAEQAEETAPIEATATKEEEGSS 24 2 Q8N4Q1;Q8N4Q1-2 Q8N4Q1 CHCHD4 Mitochondrial intermembrane space import and assembly protein 40 1 8135600.0 2905200.0 3625500.0 1604900.0 True False 2415802.5221821414 3605968.7118945923 1940477.1697808164 1.0 1.4926587247029612 0.8032432916031671 21.204071096870997 -6.714884291263903 1.778120203405712 1.3013561912441178 0.804640808777617 0.48814725337726617 0.20745252047064688 0.3653253514951958 2.254519566226391 0.09274889027066917 0.23421209865007558 1.9280385305507766e-07 6.714884291263903 -0.4967153824665008 K(ub)PALVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPALVAK 7 1 E9PI39;E9PQ49;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;H0YE72;H0YE58;P29692-3;E9PL71;P24534 E9PI39;P29692;P29692-3;P24534 EEF1D;EEF1B2 Elongation factor 1-delta;Elongation factor 1-beta 1 16761400.0 5399000.0 8871800.0 2490600.0 True False 7078141.2839903785 7548162.022005534 2232896.6035221815 1.0 1.0664045431077036 0.315463695048393 22.754939128442217 -6.885339356295299 1.0495383559954978 1.0449710181645901 0.2564736751727481 0.9777445185319354 0.05063701790262046 0.1230070298707128 0.24457901426499407 0.03696761854455229 0.0907445231330387 1.3021488859118706e-07 6.885339356295299 -0.788497342991842 down K(ub)PALVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPALVAK 7 1 E9PI39;E9PQ49;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;H0YE72;H0YE58;P29692-3;E9PL71;P24534 E9PI39;P29692;P29692-3;P24534 EEF1D;EEF1B2 Elongation factor 1-delta;Elongation factor 1-beta 1 17082800.0 7219400.0 7982600.0 1880800.0 True False 6990224.09869977 11170093.808709064 1388162.0572094477 1.0 1.5979593287698428 0.19858620233186164 22.73690727684196 -6.790586815241344 1.4939099881655966 1.333943356122752 0.18344537278982762 0.8032453404478869 0.25429925270076575 0.23447668304119396 1.0337666742665026 0.13397945675506928 0.31355565754999537 1.6196202003048704e-07 6.790586815241344 -1.1504979833329245 K(ub)PALVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPALVAK 7 1 E9PI39;E9PQ49;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;H0YE72;H0YE58;P29692-3;E9PL71;P24534 E9PI39;P29692;P29692-3;P24534 EEF1D;EEF1B2 Elongation factor 1-delta;Elongation factor 1-beta 1 11892600.0 5399000.0 5031800.0 1461800.0 True False 7395156.202488954 4809478.43806254 1116552.94671602 1.0 0.6503552198726832 0.15098436275628996 22.81814918996511 -7.438476555726959 0.4737313239616804 1.017675417106858 1.0339757656912846e-25 0.9980881853536102 0.015233596429292359 0.11324358906945038 0.05734950672170457 0.018424499412259376 0.06453266969207606 3.6435391824882987e-08 7.438476555726959 -1.017675417106858 down K(ub)PATSYVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPATSYVR 8 1 P46779;H0YKD8;P46779-2;P46779-3 P46779 RPL28 60S ribosomal protein L28 1 6968390.0 591590.0 1762200.0 4614600.0 True False 775580.2189657096 1499286.6290018002 4137125.458368851 1.0 1.933116126918765 5.334232819766854 19.564916482672647 -6.94701244835645 0.5907331355890216 0.9607730837755556 6.4779309924471145 0.9989454911376227 0.06048494044382622 0.08470804261516272 0.041101564053810644 0.06265965741565566 0.28499163203190425 1.129763531344695e-07 6.94701244835645 5.5171579086715585 K(ub)PATSYVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPATSYVR 8 1 P46779;H0YKD8;P46779-2;P46779-3 P46779 RPL28 60S ribosomal protein L28 1 5706000.0 1230200.0 1664800.0 2811000.0 True False 1191147.974377435 2329563.321817308 2074714.771807615 1.0 1.9557295751057941 1.741777525913172 20.18392121732024 -10.41542017267115 6.628289564539857 0.9998867554696798 1.8487535505094832 0.954510449514332 0.08734555832412831 0.00014618994817963308 1.2893290430074975e-05 0.08458300415898279 0.028190657729544773 3.8421987584326115e-11 10.41542017267115 0.8488667950398034 K(ub)PATSYVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPATSYVR 8 1 P46779;H0YKD8;P46779-2;P46779-3 P46779 RPL28 60S ribosomal protein L28 1 8946300.0 1276900.0 1178800.0 6490600.0 True False 1937150.6538942552 968433.929993563 5207730.06506896 1.0 0.499927007766133 2.6883454080351763 20.885504727278896 -6.846621274684038 1.2513543389886042 0.7337365808861941 2.770257027838095 0.9352337713225443 0.23827852296839708 0.16121292341088356 0.4874978177917703 0.1491251671428997 0.3444071193767578 1.4235696660281174e-07 6.846621274684038 2.0365204469519007 up K(ub)PATSYVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPATSYVR 8 1 P46779;H0YKD8;P46779-2;P46779-3 P46779 RPL28 60S ribosomal protein L28 1 6542100.0 1230200.0 2288800.0 3023100.0 True False 1022965.8071005344 2276469.780108773 3655216.232764898 1.0 2.2253625334371 3.5731558253399887 19.964326492754516 -6.969900906661063 0.26054354765772164 0.6241082337080145 5.214425430467524 0.9999815990720476 0.004507894771716969 0.07633488575073664 0.009145202841164745 0.028037046892867616 0.12706302323724022 1.0717638225977777e-07 6.969900906661063 4.59031719675951 K(ub)PATSYVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPATSYVR 8 1 P46779;H0YKD8;P46779-2;P46779-3 P46779 RPL28 60S ribosomal protein L28 1 6046500.0 1276900.0 1246600.0 3523000.0 True False 1652972.221461976 1177225.6141505295 2881850.149032616 1.0 0.7121871734234765 1.743435317070093 20.656631049371345 -6.832213538801495 1.3179046240770018 0.8464296625951355 1.7724784564670877 0.9102449269198479 0.1301684038045607 0.17809526296537823 0.6041666728549903 0.07752949075401949 0.17842290734233596 1.4715887571858537e-07 6.832213538801495 0.9260487938719522 K(ub)PDEDMKLYQTPLELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPDEDMKLYQTPLELK 16 2 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 22262100.0 8303700.0 6152700.0 7805700.0 True False 10749303.340397684 5810296.836342026 6385142.693245495 1.0 0.5405277581576804 0.5940052569964286 23.357739826359126 -10.206799146354019 4.729007668535302 1.0000767653694904 0.5672665075764982 0.988675572582881 0.021832097485677344 1.7673073003254583e-05 2.964272185641762e-06 0.021142572396027456 0.007046279163649268 6.211562417712989e-11 10.206799146354019 -0.4328102577929922 K(ub)PDHVPISSEDER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPDHVPISSEDER 13 1 A0AVT1;A0AVT1-2 A0AVT1 UBA6 Ubiquitin-like modifier-activating enzyme 6 1 10657200.0 2169000.0 5197900.0 3290300.0 True False 2807813.257381961 4908632.295678682 2691499.1613289826 1.0 1.7482046866092331 0.9585748461913627 21.421015557100606 -6.65837919609775 1.978654532809693 1.4822655797117053 0.9618840028868187 0.2286329623405452 0.3186956078228394 0.48836844439274013 3.673816625357033 0.13020631434499022 0.3532254683472541 2.1959416901109547e-07 6.65837919609775 -0.5203815768248865 K(ub)PEDVLDDDDAGSAPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPEDVLDDDDAGSAPLK 17 1 P35613-2;P35613;A0A087WUV8;P35613-3;P35613-4 P35613-2 BSG Basigin 1 27275500.0 3125900.0 7497600.0 16652000.0 True False 4046539.170700916 7080351.969079904 13621506.86394864 1.0 1.7497302436475588 3.3662115425881836 21.94825713021696 -6.958548807675449 0.45542451937314693 0.9506670133547307 4.229940734031437 0.999712534056591 0.016740650357125623 0.08022363681990138 0.023077862428134116 0.021788152442006232 0.1336098041256766 1.1001481994842426e-07 6.958548807675449 3.2792737206767066 K(ub)PFSQHVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPFSQHVR 8 1 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 1 10529700.0 2513300.0 4759300.0 3257100.0 True False 3294960.638831819 4049230.9916061014 2920086.536309368 1.0 1.2289163469466204 0.8862280483400988 21.65182980041446 -6.726656700411569 1.7351251838045614 1.1382725417426638 0.8865435346531475 0.543756630392417 0.0962595362949435 0.34257904195502736 2.018937900226774 0.043988701221994955 0.10958287370135393 1.876477233143804e-07 6.726656700411569 -0.2517290070895163 K(ub)PFSQHVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPFSQHVR 8 1 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 1 12911600.0 4002500.0 5043100.0 3866000.0 True False 3875442.8283577347 7056836.129419078 2853378.622486033 1.0 1.8209109105628316 0.7362716336845527 21.88592973900761 -6.704315672439462 1.815611583849079 1.5075937188185926 0.7392416134911305 0.4379794241595948 0.3462525626718283 0.38663410959918265 2.4807514500526056 0.15197827020467783 0.3887601547618867 1.9755331768326093e-07 6.704315672439462 -0.7683521053274621 K(ub)PFSQHVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPFSQHVR 8 1 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 1 9172600.0 1241800.0 2171800.0 5759000.0 True False 1883901.3877405336 1784225.3216491488 4620731.1257406315 1.0 0.9470906137975026 2.452745751879576 20.84529201880719 -6.898756143313667 0.969111366960626 0.9352459944722509 2.6068499267262126 0.9859368534070465 0.0827313838669071 0.11232619812401004 0.18263448321711123 0.0641744287630195 0.16595050748134021 1.2625362506776245e-07 6.898756143313667 1.6716039322539618 up K(ub)PFSQHVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPFSQHVR 8 1 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 1 9584600.0 2513300.0 3691400.0 3379900.0 True False 3442534.9293786744 3528301.7421726016 2581637.2312255288 1.0 1.024913854050395 0.749923322257031 21.715039861937353 -6.8847688216988665 1.0527937556496785 1.0166809517958924 0.728557032356969 0.9773348988012537 0.0186947292092415 0.12349190764952826 0.2474436386069656 0.013614164575729736 0.03336144379589327 1.3038606488357965e-07 6.8847688216988665 -0.28812391943892335 K(ub)PFSQHVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPFSQHVR 8 1 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 1 10422300.0 4002500.0 5248500.0 1171300.0 True False 3328256.0908144126 5220225.288754319 1416213.4145206963 1.0 1.5684566170137912 0.42551215287467675 21.666335014441888 -6.771515032838424 1.569087270501122 1.3254260036566932 0.4187771071911575 0.7361682786688055 0.23967074409208947 0.2639864688933599 1.2829642641204893 0.12039322616817219 0.2861387145556445 1.6923296644641275e-07 6.771515032838424 -0.9066488964655357 down K(ub)PFSQHVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPFSQHVR 8 1 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 1 5425500.0 1241800.0 2309200.0 1874500.0 True False 1607534.5795375386 2180690.9900500593 1533360.2339942178 1.0 1.3565437520338806 0.9538583203823463 20.61641834089964 -6.673115628032979 1.9272963358258697 1.2269792092639256 0.9554959330139866 0.2925715672969966 0.15134594149687555 0.45395932803437533 3.2540600503459767 0.06316725422062625 0.16802508622556422 2.122679237454315e-07 6.673115628032979 -0.27148327624993895 K(ub)PFTPVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPFTPVK 7 1 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 1 12568560.0 820260.0 1155300.0 10593000.0 True False 1244394.3890385344 949127.6885999013 8499288.906923166 1.0 0.7627225716866441 6.830060454941487 20.247012364226713 -6.897799775953939 0.9750920280841242 0.7322886031535161 7.439180164252123 0.9854389290862017 0.33858784558680816 0.1130423279907137 0.1867030045395013 0.2614742444202007 0.6730898115547062 1.265319566973224e-07 6.897799775953939 6.706891561098607 up K(ub)PFTPVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPFTPVK 7 1 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 1 7577660.0 820260.0 1068100.0 5689300.0 True False 1061842.739741877 1008659.2960646402 4653905.777147672 1.0 0.9499140110990775 4.382857840398277 20.018138686319162 -6.903591637605882 0.9382972797602986 0.8709928758219011 4.770663338775028 0.9882696367017229 0.17400895486739296 0.10880915595171174 0.16289089055177852 0.13809551978778567 0.36622233381502245 1.2485569670473067e-07 6.903591637605882 3.8996704629531274 up K(ub)PGDLSDELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPGDLSDELR 10 1 Q13435;E9PPJ0;H0YEX5 Q13435 SF3B2 Splicing factor 3B subunit 2 1 11277400.0 3662800.0 3219100.0 4395500.0 True False 5556735.386548575 2644626.4540569005 3526727.498383911 1.0 0.4759316883180833 0.6346761637995593 22.405806109665903 -10.870529036034036 11.072175156726098 1.0163884584519807 0.5553039260588373 0.9127649761550781 0.06480716073589518 0.02314490420621534 0.0002706412531094228 0.05539464917334681 0.020916421187092436 1.3473206432515317e-11 10.870529036034036 -0.4610845323931434 K(ub)PGDLSDELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPGDLSDELR 10 1 Q13435;E9PPJ0;H0YEX5 Q13435 SF3B2 Splicing factor 3B subunit 2 1 10338400.0 3662800.0 2484000.0 4191600.0 True False 4741566.804582132 2345763.2163885087 3428771.809447946 1.0 0.4947232240030071 0.723130549618001 22.176932431758352 -10.342527374585309 5.849248190664303 1.0000557875634792 0.608926886810504 0.7962809167891283 0.09324690021174735 6.784778048446909e-05 7.626196515390666e-06 0.0902987516793663 0.030095307633796378 4.5443589216177066e-11 10.342527374585309 -0.39112890075297524 K(ub)PHTESLELQVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPHTESLELQVR 12 1 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 17636900.0 2619500.0 7503100.0 7514300.0 True False 3390994.3880645707 7085545.889245027 6146774.503228995 1.0 2.0895186126477614 1.8126761061192147 21.693276966097393 -10.058883080352402 4.439107367115707 0.9999387162070282 1.951097359439807 0.940252290533337 0.113020480304814 78971139.97362466 173381158.45876545 74397.31535781456 0.04136124604539939 8.732064191415011e-11 10.058883080352402 0.9511586432327789 K(ub)PLFCGNSEADQLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPLFCGNSEADQLGK 15 1 P11802;F8VZZ0;F8VZ51;P11802-2 P11802 CDK4 Cyclin-dependent kinase 4 1 12168000.0 2999100.0 5106400.0 4062500.0 True False 3931849.143325717 4344545.024591297 3642151.4702517 1.0 1.104962287773967 0.9263202471626418 21.906776538929673 -6.747482745251524 1.6592690586443881 1.061905296495329 0.9260345068371734 0.6380312629854801 0.04410134974578448 0.3044526077246116 1.6483976056753613 0.021003746317457814 0.051124756460489786 1.7886165903751746e-07 6.747482745251524 -0.1358707896581557 K(ub)PLFCGNSEADQLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPLFCGNSEADQLGK 15 1 P11802;F8VZZ0;F8VZ51;P11802-2 P11802 CDK4 Cyclin-dependent kinase 4 1 74606700.0 5073700.0 11287000.0 58246000.0 True False 7697173.837155054 9272746.664266497 46733652.56987127 1.0 1.2046949777210423 6.071533988784701 22.875897399604856 -6.915735524152174 0.8557445614198236 0.8752449881652351 6.784252952988323 0.9929122693587122 0.1973371338106081 0.10074662732633706 0.11909249953471465 0.1662923019408044 0.47951853646960096 1.2141280027968508e-07 6.915735524152174 5.909007964823088 up K(ub)PLFCGNSEADQLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPLFCGNSEADQLGK 15 1 P11802;F8VZZ0;F8VZ51;P11802-2 P11802 CDK4 Cyclin-dependent kinase 4 1 83434600.0 5073700.0 8250900.0 70110000.0 True False 6568004.6675790055 7791730.16187599 57350699.389348954 1.0 1.1863161730590024 8.731829877107664 22.647023721697305 -6.912208710966904 0.8805557288211224 0.7823753018489922 9.754483833340574 0.9917287280840232 0.32756282749893534 0.10297582015074883 0.1309778797034479 0.27114322119102097 0.760446428843689 1.2240278210187942e-07 6.912208710966904 8.972108531491582 up K(ub)PLFHGDSEIDQLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPLFHGDSEIDQLFR 15 1 P06493;A0A024QZP7;P06493-2;A0A087WZZ9 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 90371200.0 8243300.0 5208900.0 76919000.0 True False 12505688.765953891 4279331.097678547 61715925.93520462 1.0 0.3421907563643204 4.935028137212492 23.57608118209519 -6.870573949707347 1.1309956495231455 0.626608131268527 5.207026833832742 0.9652556861905802 0.3779965799904019 0.13630881288207983 0.3255185598954413 0.2592770191252265 0.6144956273453273 1.3471813138499707e-07 6.870573949707347 4.580418702564216 up K(ub)PLFHGDSEIDQLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPLFHGDSEIDQLFR 15 1 P06493;A0A024QZP7;P06493-2;A0A087WZZ9 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 116441100.0 8243300.0 4334800.0 103863000.0 True False 10671114.3497357 4093564.5694045583 84960999.72437531 1.0 0.3836117236908765 7.961773901005906 23.34720750418764 -6.887186060930371 1.038843715304231 0.5649292382537875 8.578832247396715 0.9790367969353402 0.49753387745665206 0.12145768345787224 0.23540113278451574 0.36618765100888484 0.9041707482733459 1.2966236510099604e-07 6.887186060930371 8.013903009142927 up K(ub)PLLESGTLGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPLLESGTLGTK 12 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 100369000.0 25514000.0 36089000.0 38766000.0 True False 33449101.077927485 30704661.873820174 34754866.189729765 1.0 0.9179517799981082 1.0390373752873119 24.995464104141284 -6.7242138956295365 1.744194529283631 0.9503088940304981 1.0388944270550682 0.5323159421544612 0.034509534754224844 0.3471885697588781 2.0663719526527315 0.015696584711684707 0.039209725709610455 1.8870617179708263e-07 6.7242138956295365 0.08858553302457006 K(ub)PLLESGTLGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPLLESGTLGTK 12 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 88412000.0 25686000.0 27039000.0 35687000.0 True False 24870611.989805568 37835813.706522204 26339504.11294849 1.0 1.521306099022857 1.059061358190342 24.567938672522068 -10.363927613273018 3.2545670974954284 0.9975365804585142 1.2901837283409197 0.3444606546399782 0.18871062766787508 342346873.4087494 472292680.31490874 8042089.067658213 0.06906103460980359 4.3258592697734675e-11 10.363927613273018 0.2926471478824054 K(ub)PLLESGTLGTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPLLESGTLGTK 12 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 204888000.0 84631000.0 55825000.0 64432000.0 True False 128391414.35486323 45862592.58728425 51696986.95845116 1.0 0.3572091858145892 0.4026514328720219 26.935973490517064 -9.843445298556784 6.7546982250590135 1.0000000095557002 0.3799303093432807 0.9959880636935183 0.01855171967612282 2.664826144683103e-09 4.358897636486971e-10 0.017962625604906923 0.0059875417790811155 1.4340183260690271e-10 9.843445298556784 -0.6200697002124196 K(ub)PLLESGTLGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPLLESGTLGTK 12 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 102419000.0 25514000.0 25232000.0 51673000.0 True False 34947215.28992465 24117166.808934014 39468901.63884041 1.0 0.6901026765324858 1.1293861702972188 25.058674165664176 -6.717162709304 1.7696654781908834 0.8108931517948219 1.1285887843004816 0.49905595960730464 0.13045314080239753 0.3608467611326602 2.206979611708115 0.05856922207402994 0.14751576556529844 1.917950042194276e-07 6.717162709304 0.3176956325056597 K(ub)PLLESGTLGTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPLLESGTLGTK 12 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 95977400.0 25686000.0 54453000.0 15838400.0 True False 21359047.082738042 54159650.880925775 19150136.21151254 1.0 2.5356773020410883 0.8965819559894739 24.348343947956344 -6.660829124297921 1.9697556019077556 1.9878069718064388 0.9033771765896565 0.2392251696067863 0.6537242716999917 0.48247389834321 3.599396240962757 0.2680392578223407 0.7248418123137883 2.1835888886571227e-07 6.660829124297921 -1.0844297952167823 K(ub)PLLESGTLGTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPLLESGTLGTK 12 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 184651000.0 84631000.0 57492000.0 42528000.0 True False 109556497.82641445 54292519.66047031 34788340.3741297 1.0 0.4955664039799216 0.31753790112248464 26.707099812609513 -13.999999999999964 0.1451309379211987 3.4227277817900252 0.11026637050280602 0.9995832939483758 0.005900299231379573 11.942760684143849 0.11970665657323346 8.173617354378653 0.1860106557818128 1.0000000000000819e-14 13.999999999999964 -3.3124614112872193 K(ub)PLPDHVSIVEPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPLPDHVSIVEPK 13 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 79924900.0 9728900.0 14345000.0 55851000.0 True False 12754682.114801617 12204781.916372035 50072074.28062218 1.0 0.9568864050487442 3.9257798689090246 23.60452360728252 -6.903605570384817 0.9381868422640224 0.8884762314991488 4.261283354059802 0.9882764653590703 0.15044841649069862 0.10879990348913758 0.16282766571542315 0.119405641201789 0.3166899697013261 1.2485169122229986e-07 6.903605570384817 3.372807122560653 up K(ub)PLPDHVSIVEPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPLPDHVSIVEPK 13 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 56547700.0 13113000.0 8843700.0 34591000.0 True False 12696734.992693316 12375035.529286245 25530579.39224374 1.0 0.9746628197255277 2.01079879251918 23.597954215110818 -6.901297825275745 0.9530553783254566 0.9584417866493146 2.1224601080278944 0.9872001789475392 0.054597088741677846 0.11045539208068235 0.17209330846462575 0.04285917386941849 0.11225256280517444 1.2551689137621866e-07 6.901297825275745 1.1640183213785797 up K(ub)PLPDHVSIVEPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPLPDHVSIVEPK 13 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 202124000.0 25897000.0 45047000.0 131180000.0 True False 39287642.32430071 37008010.89618252 105252215.50176352 1.0 0.9419758658638532 2.6790158246951243 25.22757225758468 -6.899172588999569 0.9664967432187909 0.9261315083034837 2.8583061706099873 0.9861497747773247 0.09479926878227707 0.11201644159989464 0.1808803152984095 0.07367864726209569 0.1909130843031392 1.2613261828716519e-07 6.899172588999569 1.9321746623065037 up K(ub)PLPDHVSIVEPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPLPDHVSIVEPK 13 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 120308900.0 9728900.0 11121000.0 99459000.0 True False 13325937.243636735 10629637.447770897 75968832.622403 1.0 0.7976652788791012 5.700824732510192 23.66773366880541 -6.897272806984388 0.9783294725574169 0.780612007746828 6.187947508105476 0.9851605241214635 0.2759392095941007 0.11344132148953012 0.1889490020189095 0.2125742260153514 0.5458998000492208 1.2668558260663938e-07 6.897272806984388 5.4073355003586485 up K(ub)PLPDHVSIVEPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPLPDHVSIVEPK 13 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 60034000.0 13113000.0 14055000.0 32866000.0 True False 10904040.504397104 13979282.925300937 39738128.64478545 1.0 1.2820277877419592 3.6443489575044103 23.378359490545094 -6.929250919231211 0.7529159557030572 0.9630604019370202 4.120197298231588 0.996388972655115 0.07125009302288583 0.09302858455594996 0.07959944329757385 0.06462544693417734 0.21463640724170777 1.1769257930109192e-07 6.929250919231211 3.157136896294568 up K(ub)PLPDHVSIVEPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPLPDHVSIVEPK 13 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 237994000.0 25897000.0 38437000.0 173660000.0 True False 33524177.006187513 36297947.161161475 142055661.90207326 1.0 1.0827393959428746 4.2374093740125 24.99869857967713 -6.912529233971762 0.8783495340491254 0.9099644731117253 4.667925891257474 0.9918412125726813 0.13612184734702457 0.10276880250147281 0.12987631665316962 0.1128576814417409 0.317271319765236 1.223124783214796e-07 6.912529233971762 3.757961418145749 up K(ub)PPLLNNADSVQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPPLLNNADSVQAK 14 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 14975800.0 5369400.0 7200900.0 2405500.0 True False 7039335.397343562 6126553.78888836 2156601.935185342 1.0 0.8703312803081299 0.3063644241186718 22.74700779588312 -6.942956371971543 0.63146314119788 1.0061525800479245 0.14007216521635146 0.9985260303817616 0.011560292139466249 0.08644348654996233 0.0486599106588212 0.011523264793840568 0.04794325359197553 1.1403643396705145e-07 6.942956371971543 -0.866080414831573 down K(ub)PPLLNNADSVQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPPLLNNADSVQAK 14 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 11991000.0 4226100.0 3945200.0 3819700.0 True False 4091944.7687501824 5520538.933946208 2819205.9814562565 1.0 1.3491235209492738 0.6889648176549892 21.964355241683084 -6.763047532043515 1.6012756697011652 1.2020228446604773 0.6862058996955505 0.7031841823301628 0.14691192902215994 0.27782498446089143 1.4046957820550394 0.07237025130529022 0.17337856087318904 1.725649015280343e-07 6.763047532043515 -0.5158169449649268 K(ub)PPLLNNADSVQAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPPLLNNADSVQAK 14 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 22154100.0 7903300.0 4893700.0 9357100.0 True False 10230977.647333732 4621361.293091971 7654203.811953754 1.0 0.4517028042081914 0.7481400190477883 23.286440676310274 -10.092236149857586 5.330663977590132 1.0000057964387765 0.5999214116276695 0.7083395289944093 0.12101998618928264 8.336896186350009e-06 1.4196556914145562e-06 0.1171787943573322 0.03905903258894611 8.086560687138787e-11 10.092236149857586 -0.400084384811107 K(ub)PQLVTGGESFSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPQLVTGGESFSR 13 1 J3KTE1;Q8WU67 J3KTE1 ABHD3 Phospholipase ABHD3 1 18844500.0 2799100.0 4294400.0 11751000.0 True False 3669647.2065229556 3653692.259440092 10535119.243551431 1.0 0.9956521850235349 2.870880673440434 21.807209940876337 -6.906376144096556 0.9200665425540672 0.9350776623416516 3.09533254527496 0.9894804969223939 0.09056130355345678 0.10686321975150945 0.15212974815387853 0.07284010786402538 0.1963626212756407 1.2405773733929925e-07 6.906376144096556 2.1602548829333084 up K(ub)PQLVTGGESFSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPQLVTGGESFSR 13 1 J3KTE1;Q8WU67 J3KTE1 ABHD3 Phospholipase ABHD3 1 31067100.0 3105800.0 4577300.0 23384000.0 True False 3007208.0790289696 6405039.760304156 17259028.895037062 1.0 2.1298957677622194 5.739220047789317 21.519993265702077 -6.9500312244780105 0.5585001383389483 0.9524191503965209 7.088748711745431 0.999203735734904 0.057032089493471515 0.08347319585584335 0.0359104105130122 0.061246483141831794 0.299935856508492 1.121937787421292e-07 6.9500312244780105 6.13632956134891 K(ub)PQLVTGGESFSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPQLVTGGESFSR 13 1 J3KTE1;Q8WU67 J3KTE1 ABHD3 Phospholipase ABHD3 1 100108900.0 6767900.0 38409000.0 54932000.0 True False 10267399.099765792 31554613.859113287 44074666.12244907 1.0 3.0732820992448877 4.292680716331992 23.291567433882264 -8.559656045325063 0.2528540075777709 3.1473181113433698e-16 5.210571393549363 0.9992715129328483 0.03668587951196984 0.19447299240063257 0.07032453360413732 0.6155386585823512 0.4712486844676991 2.756410874911532e-09 8.559656045325063 5.210571393549363 K(ub)PQLVTGGESFSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPQLVTGGESFSR 13 1 J3KTE1;Q8WU67 J3KTE1 ABHD3 Phospholipase ABHD3 1 18380900.0 2799100.0 2196800.0 13385000.0 True False 3834002.912833266 2099738.112153864 10223738.672728099 1.0 0.5476621066524416 2.666596480275734 21.87042000239923 -6.850895233272186 1.2308741299818944 0.75843579874499 2.7527226850401356 0.9415826519435498 0.22022628353417237 0.15647651505190546 0.45576941899083173 0.13997575545511848 0.3240808274244122 1.4096288082360685e-07 6.850895233272186 1.9942868862951455 up K(ub)PQLVTGGESFSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPQLVTGGESFSR 13 1 J3KTE1;Q8WU67 J3KTE1 ABHD3 Phospholipase ABHD3 1 20394800.0 3105800.0 6011000.0 11278000.0 True False 2582610.3102689325 5978617.549909915 13636177.656419713 1.0 2.3149514760851972 5.27999814846234 21.300398541136353 -6.957633057924888 0.4675985999598185 0.9198293900127764 6.796182470621515 0.9996720917765349 0.03241491337516287 0.08055771659516235 0.024339319688031123 0.04081403984038711 0.24476627489781674 1.1024704103103126e-07 6.957633057924888 5.876353080608738 K(ub)PQLVTGGESFSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPQLVTGGESFSR 13 1 J3KTE1;Q8WU67 J3KTE1 ABHD3 Phospholipase ABHD3 1 74980900.0 6767900.0 29242000.0 38971000.0 True False 8761179.965253754 27614656.994216114 31878677.876227673 1.0 3.1519335413419167 3.638628358583701 23.062693755974713 -9.861688444455444 0.3779394803429858 2.306541439315833e-21 3.7144645870559048 0.9987266528617017 0.04091150243468218 1.1969311040282513 0.16548585127685564 1.5301297505208786 0.13136421331469086 1.3750280432283376e-10 9.861688444455444 3.7144645870559048 K(ub)PQSLEDTDLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPQSLEDTDLSR 12 1 P08910 P08910 ABHD2 Abhydrolase domain-containing protein 2 1 5257600.0 541900.0 1243800.0 3471900.0 True False 710436.1477670645 1058229.8882944258 3112661.092816461 1.0 1.4895496120523906 4.381338284376023 19.438345463891626 -6.936167390662934 0.6943132416197065 0.9644071990413365 5.080417783137358 0.9976173969846724 0.07282914518761004 0.08955976825069724 0.06290535940030803 0.06898171176918404 0.2533771382130911 1.1583308132171867e-07 6.936167390662934 4.1160105840960215 up K(ub)PQSLEDTDLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPQSLEDTDLSR 12 1 P08910 P08910 ABHD2 Abhydrolase domain-containing protein 2 1 9916900.0 1008400.0 1595700.0 7312800.0 True False 976388.8939702532 2232871.3314655693 5397358.3007024955 1.0 2.2868667856166707 5.527877604952492 19.89709635957517 -6.95530313674004 0.4972287820291987 0.9335041116744277 7.02037087064851 0.9995544107512742 0.04021300256577605 0.08142358352821706 0.027670986378616053 0.04740892726198354 0.2673325207549914 1.1084008834387009e-07 6.95530313674004 6.086866758974082 K(ub)PQSLEDTDLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPQSLEDTDLSR 12 1 P08910 P08910 ABHD2 Abhydrolase domain-containing protein 2 1 65640500.0 1632200.0 28077000.0 35931300.0 True False 2476166.7298035887 23066439.983397733 28829462.80575172 1.0 9.315382403683042 11.642779324491809 21.23967702933773 -9.053693636400844 0.5034643628730857 2.836497861162175e-16 11.674729070648521 0.9969823783924522 0.2509544500375885 0.5030737582908557 0.1999674569228741 1.7002638548620892 0.46788862911834633 8.837030697077937e-10 9.053693636400844 11.674729070648521 K(ub)PQSLEDTDLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPQSLEDTDLSR 12 1 P08910 P08910 ABHD2 Abhydrolase domain-containing protein 2 1 7091200.0 541900.0 1235200.0 5314100.0 True False 742255.0742968624 1180624.7797398274 4059019.0273249475 1.0 1.5905917259753761 5.468496165108811 19.501555525414517 -6.933957887836039 0.7135546903963085 0.948799124258255 6.3512823201162805 0.9972605797836904 0.10373607331539376 0.09063413590389173 0.06798951148118472 0.09684140677505239 0.34356771676631803 1.1642389165071191e-07 6.933957887836039 5.402483195858025 up K(ub)PQSLEDTDLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPQSLEDTDLSR 12 1 P08910 P08910 ABHD2 Abhydrolase domain-containing protein 2 1 8337970.0 1008400.0 3000800.0 4328770.0 True False 838529.279694504 2984634.094787833 5233895.793028902 1.0 3.5593677729121223 6.241756751697131 19.677501635009445 -6.970533101546565 0.24512087480927522 0.0959728755817372 9.78323219113903 0.9999862467309457 0.007936772986049693 0.07613012296287608 0.008408943068257686 0.06186087502955901 0.2591830697963716 1.0702048097256754e-07 6.970533101546565 9.687259315557293 K(ub)PQSLEDTDLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPQSLEDTDLSR 12 1 P08910 P08910 ABHD2 Abhydrolase domain-containing protein 2 1 47296800.0 1632200.0 18110000.0 27554600.0 True False 2112915.075472031 17102162.58003056 22539945.534071557 1.0 8.094107888463 10.667700654762982 21.01080335143018 -8.890794744749362 0.44818015666803496 4.920283625690744e-19 10.930823615572564 0.9967963224377554 0.23139157310385128 0.39854573507000973 0.1647951959359155 1.4285564721007504 0.5768525055477467 1.2858942527116905e-09 8.890794744749362 10.930823615572564 K(ub)PRPSVEPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPRPSVEPAR 10 2 E7EXA6;Q8WVB6;Q8WVB6-2;A0A0D9SF58;H0Y7D3;F8WCC1 E7EXA6 CHTF18 Chromosome transmission fidelity protein 18 homolog 1 5872400.0 642470.0 412230.0 4817700.0 True False 831690.0799770349 389289.0381207065 3940928.033776448 1.0 0.4680698345367493 4.7384574238101616 19.66568649874427 -6.8756859382385045 1.1035336034257683 0.6858382002715356 5.017184473992643 0.9700378588038346 0.32890837673909895 0.13152218406704988 0.2959382950259309 0.230409972614736 0.5515910872619296 1.331416889285046e-07 6.8756859382385045 4.331346273721107 up K(ub)PSPEELDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPSPEELDK 9 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 29669700.0 10209000.0 11954000.0 7506700.0 True False 13384097.86409664 10170509.79632705 6729978.693350994 1.0 0.759895056028381 0.5028339423163083 23.674016563679125 -6.970257235094497 0.2519674474231064 1.0796298875001669 0.17555123398493813 0.9999843190412209 0.0008038687208636629 0.07621932766332361 0.008731037315580973 0.00565782652077914 0.024558451180532632 1.0708848261732316e-07 6.970257235094497 -0.9040786535152288 K(ub)PSPEELDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPSPEELDK 9 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 36885000.0 12341000.0 13508000.0 11036000.0 True False 11949241.710121864 18901814.843289416 8145340.527096691 1.0 1.5818422040352755 0.6816617091440207 23.510415732981777 -6.732226534071118 1.7153720410501814 1.3492806710919507 0.6820008782489367 0.5694705695137805 0.2445517098114138 0.33206640235426466 1.9152807087356518 0.11293739464489895 0.27951498280736153 1.8525650475282033e-07 6.732226534071118 -0.667279792843014 K(ub)PSPEELDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPSPEELDK 9 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 37863000.0 17140000.0 20723000.0 0.0 True False 26002633.101846304 17024818.740461968 0.0 1.0 0.6547344137718548 0.0 24.632154386335745 -7.523788193148621 0.7058726262717677 0.9938420740100911 5.766149037013823e-17 0.9870646694098415 0.04716685520866867 0.11982828742838202 0.14332284532752285 0.04187309125883511 0.07599463502805308 2.993724329861358e-08 7.523788193148621 -0.993842074010091 down K(ub)PSPEELDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPSPEELDK 9 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 27905800.0 10209000.0 8702400.0 8994400.0 True False 13983543.187851403 8317899.193011541 6870107.965482682 1.0 0.5948348770601968 0.4912995135203846 23.737226625202016 -13.999999999999957 0.1915746745221251 3.18387468129649 0.4181876635322059 0.9994886186378954 0.004963897953921763 12.376781338122663 0.1388022785966555 10.095226932544021 0.07032111808242562 1.0000000000000981e-14 13.999999999999957 -2.7656870177642845 K(ub)PSPEELDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPSPEELDK 9 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 34177700.0 12341000.0 16263000.0 5573700.0 True False 10262088.298998283 16175387.99104726 6739134.900122949 1.0 1.5762277150379025 0.6567020964710252 23.290821008416053 -6.7372694866739575 1.6966706253961574 1.3439220515318182 0.6564713063621394 0.5927009027960006 0.2421255569081519 0.3227443723644601 1.823168146035494 0.11294477500963988 0.27799384118008125 1.8311777946426853e-07 6.7372694866739575 -0.6874507451696789 K(ub)PSPEELDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPSPEELDK 9 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 48060400.0 17140000.0 22953000.0 7967400.0 True False 22188067.87991094 21675645.372691397 6517414.952427605 1.0 0.9769054921774649 0.2937351277137776 24.403280708428195 -6.914083228799268 0.8674773274766463 1.0185200129633836 0.19728224038883968 0.9923730655749577 0.028612575764793927 0.10177947431545048 0.12458332204828211 0.02390905842420481 0.06802416952626816 1.2187560124438164e-07 6.914083228799268 -0.8212377725745439 down K(ub)PTDGASSSNCVTDISHLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPTDGASSSNCVTDISHLVR 20 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YDS9 P49321 NASP Nuclear autoantigenic sperm protein 1 68749400.0 8425400.0 35168000.0 25156000.0 True False 11045780.991689673 29921071.483790327 22553098.4333912 1.0 2.708823532378701 2.041783958088531 23.396992092230565 -10.373052326598108 5.639018917537816 0.9995991066658888 2.3753037452336225 0.8500308584319631 0.27231776587572826 0.001372855041024194 0.0001526344186944717 0.26374017157138163 0.08789018100942204 4.235919258895951e-11 10.373052326598108 1.3757046385677336 K(ub)PTDGASSSNCVTDISHLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPTDGASSSNCVTDISHLVR 20 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YDS9 P49321 NASP Nuclear autoantigenic sperm protein 1 114174300.0 49606700.0 42210000.0 22357600.0 True False 48031962.46183473 59064673.1222421 16501473.84637704 1.0 1.2296951882649756 0.3435519391798491 25.5174914187814 -6.837869655781046 1.2921800148227944 1.1222456369868916 0.31559872935510314 0.9207508591590624 0.10570499445763237 0.17129211887006787 0.5564873103379661 0.06416584619657022 0.14775794605152337 1.452547503302821e-07 6.837869655781046 -0.8066469076317885 down K(ub)PTDGASSSNCVTDISHLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPTDGASSSNCVTDISHLVR 20 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YDS9 P49321 NASP Nuclear autoantigenic sperm protein 1 250374000.0 92357000.0 58500000.0 99517000.0 True False 140112321.20112124 48060217.93741375 79847421.33014931 1.0 0.34301207435159636 0.5698815111023251 27.06200858820204 -10.14247396233354 5.253274719774688 1.000016998954343 0.4564467927266693 0.8844423608556047 0.09261905971321811 1.8440254806460284e-05 3.0100912362859034e-06 0.08968081934371921 0.02989267298404588 7.20320936023865e-11 10.14247396233354 -0.5435702062276737 K(ub)PTDGASSSNCVTDISHLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPTDGASSSNCVTDISHLVR 20 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YDS9 P49321 NASP Nuclear autoantigenic sperm protein 1 60474100.0 8425400.0 35484700.0 16564000.0 True False 11540498.067873763 33916868.621788986 12651924.346288256 1.0 2.9389432260472512 1.0963066127543024 23.460202153753457 -6.634213267653771 2.065264299104194 2.2734635664261313 1.1038411851024652 0.13284564669000776 0.830820739908134 0.5481022301759076 4.4605894753273665 0.32841238191142424 0.9201415161908364 2.321596457165984e-07 6.634213267653771 -1.1696223813236661 K(ub)PTDGASSSNCVTDISHLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPTDGASSSNCVTDISHLVR 20 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YDS9 P49321 NASP Nuclear autoantigenic sperm protein 1 93386300.0 49606700.0 27232000.0 16547600.0 True False 41250168.99942616 27085295.810871225 20007626.652542207 1.0 0.6566105416743387 0.48503138624281855 25.297896694215677 -13.999999999999973 0.09010654120379182 2.757501240198511 0.05629758103491372 0.999841911380567 0.0026919407915046226 12.16276990135182 0.08724355657716926 4.093053927271789 0.3851701022842307 1.0000000000000614e-14 13.999999999999973 -2.701203659163597 K(ub)PTDGASSSNCVTDISHLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPTDGASSSNCVTDISHLVR 20 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YDS9 P49321 NASP Nuclear autoantigenic sperm protein 1 195093000.0 92357000.0 72893000.0 29843000.0 True False 119557957.12864257 68836440.47190323 24411880.215038385 1.0 0.5757579179597077 0.20418448760187136 26.83313491029449 -7.794513726414396 0.3329703853184279 1.0843224974223336 1.3247876536465525e-19 0.99907573175942 0.00988445034412236 0.11699318350738816 0.05436288915828036 0.03807761473444233 0.08093872425655674 1.6050415279720006e-08 7.794513726414396 -1.0843224974223336 down K(ub)PVLGQAGTLAVGTEGGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPVLGQAGTLAVGTEGGLR 19 1 Q9NTJ4-2;Q9NTJ4;Q9NTJ4-4;Q9NTJ4-3;A0A0C4DGU9 Q9NTJ4-2 MAN2C1 Alpha-mannosidase 2C1 1 8143800.0 2205300.0 2415200.0 3523300.0 True False 2891169.656155581 2054861.574375862 3158742.7138800765 1.0 0.7107371129192859 1.0925483764520032 21.463221839125907 -6.704110512893388 1.8162617025861802 0.8211074801382333 1.0915026563744572 0.43709090216274615 0.122012081248467 0.387027919775674 2.4849018828383014 0.053536710821176066 0.13698538343408695 1.976466633859985e-07 6.704110512893388 0.2703951762362239 K(ub)PVLGQAGTLAVGTEGGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPVLGQAGTLAVGTEGGLR 19 1 Q9NTJ4-2;Q9NTJ4;Q9NTJ4-4;Q9NTJ4-3;A0A0C4DGU9 Q9NTJ4-2 MAN2C1 Alpha-mannosidase 2C1 1 36677100.0 6139100.0 13330000.0 17208000.0 True False 9313463.528328165 10951157.352234637 13806831.257465674 1.0 1.1758415458357896 1.4824593681470184 23.150886352136165 -6.962635575697829 0.39654988685368586 0.9824898551565828 1.6869445931284615 0.9998557957591682 0.0023940160049758614 0.0787728036582837 0.01774895082645219 0.0039479782684304 0.025723380477702035 1.0898442176135613e-07 6.962635575697829 0.7044547379718786 K(ub)PVLGQAGTLAVGTEGGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPVLGQAGTLAVGTEGGLR 19 1 Q9NTJ4-2;Q9NTJ4;Q9NTJ4-4;Q9NTJ4-3;A0A0C4DGU9 Q9NTJ4-2 MAN2C1 Alpha-mannosidase 2C1 1 9328500.0 2205300.0 3059200.0 4064000.0 True False 3020659.005991645 2924034.428578432 3104166.9007072826 1.0 0.9680120870242047 1.0276455881150421 21.5264319006488 -6.761011863637011 1.608815809382613 0.9814430139069275 1.0278732927260243 0.6950392334214869 0.013456127520505594 0.28121397768941536 1.4347968220714185 0.0065987593720093244 0.015841078134358984 1.733756636018745e-07 6.761011863637011 0.04643027881909689 K(ub)PVLGQAGTLAVGTEGGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPVLGQAGTLAVGTEGGLR 19 1 Q9NTJ4-2;Q9NTJ4;Q9NTJ4-4;Q9NTJ4-3;A0A0C4DGU9 Q9NTJ4-2 MAN2C1 Alpha-mannosidase 2C1 1 21597800.0 6139100.0 7337100.0 8121600.0 True False 7947185.969752704 6928783.935170752 6643552.134653208 1.0 0.8718537557246012 0.8359628376558474 22.922012674228615 -13.999999999319835 0.1785387902687072 1.6619535031688462 0.8070185668829201 0.9994999666934511 0.0015744519501876954 12.18621117927447 0.1339338909724398 2.7974400399998274 0.02713405115035712 1.0000000015661383e-14 13.999999999319835 -0.8549349362859261 K(ub)PVTDCVISVPSFFTDAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPVTDCVISVPSFFTDAER 19 1 Q92598-2;Q92598;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 4260000.0 1061600.0 1929300.0 1269100.0 True False 1391767.8805490222 1641455.9603524988 1137785.706066812 1.0 1.1794035365329598 0.8175111108455673 20.40848718747579 -6.771926116813574 1.5672270198202305 1.1026482301359535 0.8153328363850258 0.7378227591159003 0.07564959771190204 0.2633258635104201 1.2767294447930873 0.03804246491065377 0.09039237831299415 1.6907285378460372e-07 6.771926116813574 -0.28731539375092763 K(ub)PVVDCVVSVPCFYTDAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPVVDCVVSVPCFYTDAER 19 1 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 1 23607200.0 6380200.0 6666000.0 10561000.0 True False 9679229.855099173 5476400.21830428 8473613.72094927 1.0 0.5657888386046773 0.8754429688933603 23.206460830829137 -10.119644522448269 5.405690716971991 1.0000048671221733 0.7206159037489059 0.5204748405970763 0.1264157693258263 7.415351093350939e-06 1.2076265008787855e-06 0.12240367406018615 0.04080051410801949 7.591987380881471e-11 10.119644522448269 -0.27938896337326735 K(ub)QADLDLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQADLDLAR 9 1 P36956;P36956-4;P36956-3;P36956-2;Q12772;A0A087X1T2;G3V0I8;Q12772-2 P36956;Q12772 SREBF1;SREBF2 Sterol regulatory element-binding protein 1;Processed sterol regulatory element-binding protein 1;Sterol regulatory element-binding protein 2;Processed sterol regulatory element-binding protein 2 1 17744430.0 2166230.0 3311200.0 12267000.0 True False 2839948.507801159 2817181.8669565106 10997728.513372941 1.0 0.9919834318185313 3.8725098300771568 21.43743334123252 -6.906269881909873 0.9207421802481695 0.8999542913556107 4.216555183656285 0.9894366549365843 0.1393679314868784 0.10693722828985047 0.15252169943784663 0.11203846895892126 0.3018463469994352 1.2408809521828573e-07 6.906269881909873 3.3166008923006745 up K(ub)QADLDLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQADLDLAR 9 1 P36956;P36956-4;P36956-3;P36956-2;Q12772;A0A087X1T2;G3V0I8;Q12772-2 P36956;Q12772 SREBF1;SREBF2 Sterol regulatory element-binding protein 1;Processed sterol regulatory element-binding protein 1;Sterol regulatory element-binding protein 2;Processed sterol regulatory element-binding protein 2 1 41039600.0 2148600.0 2821000.0 36070000.0 True False 2080393.8690841768 3947440.0113206566 26622184.9231948 1.0 1.8974483966626876 12.796704181268481 20.98842526075831 -6.923220513068544 0.8004690560634262 0.786270547933408 14.69151076365895 0.9950299494542847 0.3780148932257549 0.09631377753950776 0.09606234452156943 0.3313821126602492 1.025400238140704 1.1933820107646232e-07 6.923220513068544 13.905240215725541 up K(ub)QADLDLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQADLDLAR 9 1 P36956;P36956-4;P36956-3;P36956-2;Q12772;A0A087X1T2;G3V0I8;Q12772-2 P36956;Q12772 SREBF1;SREBF2 Sterol regulatory element-binding protein 1;Processed sterol regulatory element-binding protein 1;Sterol regulatory element-binding protein 2;Processed sterol regulatory element-binding protein 2 1 124524700.0 3326700.0 49452000.0 71746000.0 True False 5046847.114347264 40626904.22976044 57565371.65261108 1.0 8.049957391074038 11.40620477465292 22.26695095262906 -8.618050844580178 0.41011161766460036 9.801846377442152e-16 12.07849068633555 0.9967572836606511 0.2469474145139992 0.24722862065654938 0.1345251190257713 1.220960724803636 0.8167444806672763 2.4096233079998192e-09 8.618050844580178 12.078490686335549 K(ub)QADLDLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQADLDLAR 9 1 P36956;P36956-4;P36956-3;P36956-2;Q12772;A0A087X1T2;G3V0I8;Q12772-2 P36956;Q12772 SREBF1;SREBF2 Sterol regulatory element-binding protein 1;Processed sterol regulatory element-binding protein 1;Sterol regulatory element-binding protein 2;Processed sterol regulatory element-binding protein 2 1 21054670.0 2166230.0 4644540.0 14243900.0 True False 2967143.771164591 4439328.865360111 10879784.18232885 1.0 1.4961623728861961 3.6667532891601615 21.50064340275541 -6.942822812236757 0.6327567445711711 0.9763150017042407 4.304137926455894 0.9985107614502574 0.04468897470188767 0.08650211101507661 0.04891998436851003 0.04449534800271595 0.184620956912107 1.1407150928740795e-07 6.942822812236757 3.3278229247516533 up K(ub)QADLDLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQADLDLAR 9 1 P36956;P36956-4;P36956-3;P36956-2;Q12772;A0A087X1T2;G3V0I8;Q12772-2 P36956;Q12772 SREBF1;SREBF2 Sterol regulatory element-binding protein 1;Processed sterol regulatory element-binding protein 1;Sterol regulatory element-binding protein 2;Processed sterol regulatory element-binding protein 2 1 30753700.0 2148600.0 10577000.0 18028100.0 True False 1786656.09911901 10520019.60162987 21797692.357483633 1.0 5.888105498767912 12.200273106968908 20.768830536192585 -6.967626783899131 0.30967302196241725 0.023795744856008636 18.265133004277974 0.9999575064774996 0.02988693186489776 0.07708054498665683 0.01177265064755458 0.10001905529374602 0.560577859138914 1.0773906843462526e-07 6.967626783899131 18.241337259421964 K(ub)QADLDLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQADLDLAR 9 1 P36956;P36956-4;P36956-3;P36956-2;Q12772;A0A087X1T2;G3V0I8;Q12772-2 P36956;Q12772 SREBF1;SREBF2 Sterol regulatory element-binding protein 1;Processed sterol regulatory element-binding protein 1;Sterol regulatory element-binding protein 2;Processed sterol regulatory element-binding protein 2 1 98004500.0 3326700.0 47257400.0 47420400.0 True False 4306478.729060661 44627484.14740671 38790373.77439291 1.0 10.362871142554317 9.007445807785043 22.03807727472151 -9.596295286176357 9.206020106750175 0.999999999628846 9.685158475169683 0.9820611135249693 0.5533500757709726 0.0 0.0 0.5357789070208938 0.17859296900696459 2.5334055277691883e-10 9.596295286176357 8.685158475540836 K(ub)QAEILQESR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQAEILQESR 10 1 E5RJD8;O75347;E5RIW3;O75347-2 E5RJD8 TBCA Tubulin-specific chaperone A 1 9930150.0 4109150.0 4198800.0 1622200.0 True False 5387135.443065207 3572355.4067942123 1454350.3052411834 1.0 0.6631270820177467 0.2699672804984605 22.361086907117123 -7.314480143117389 0.33989221358283994 1.0550931960310552 2.9288782431280227e-16 0.9997400910201256 0.004809577147710618 0.10523964682578699 0.02590113970542414 0.01281481421421524 0.051262950897730135 4.847522760397263e-08 7.314480143117389 -1.055093196031055 down K(ub)QAELESAQCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQAELESAQCR 11 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 7198340.0 1998440.0 2686100.0 2513800.0 True False 2619974.19292049 2285344.350335792 2253696.090072297 1.0 0.8722774279651643 0.8601978203304734 21.321121170426977 -13.999999999999979 0.3335814144368685 2.42074056664272 0.858147195486568 0.9997222188297241 0.0010541362062668467 19.13069249987661 0.18489258027299335 19.104104985503657 0.0038200346955689917 1.000000000000049e-14 13.999999999999979 -1.5625933711561522 K(ub)QAELESAQCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQAELESAQCR 11 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 7144270.0 3139970.0 1928500.0 2075800.0 True False 3040293.3710826775 2698560.106994643 1532085.7073348442 1.0 0.887598589222217 0.5039269308373533 21.53577911160655 -6.94851835598364 0.5748804768047615 1.00467965187845 0.36803503415629096 0.9990798169102663 0.006442277108723068 0.08408622441123927 0.03846721252368534 0.006787808758596056 0.032006722751325545 1.1258528823501039e-07 6.94851835598364 -0.636644617722159 K(ub)QAELESAQCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQAELESAQCR 11 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 16674120.0 3360120.0 1819600.0 11494400.0 True False 5097547.69767653 1494878.1634003115 9222526.801825508 1.0 0.2932543748598329 1.8092085349253622 22.28137193890483 -6.779915873454356 1.5361268222690745 0.599793421418473 1.8212057832259294 0.767155468966633 0.29886419141922377 0.2506828582554121 1.1683758851485937 0.15323721190245554 0.36161171703280764 1.6599084147160293e-07 6.779915873454356 1.2214123618074564 K(ub)QAELESAQCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQAELESAQCR 11 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 8129030.0 1998440.0 2020500.0 4110090.0 True False 2737317.273810339 1931227.6290999972 3139371.391960626 1.0 0.7055183728891364 1.1468788883177683 21.38433123194987 -6.726883826878874 1.7347438224845442 0.8221690524983167 1.1464633385796117 0.5447047650105299 0.12382618480563153 0.34210514500921113 2.015455535635895 0.05660179466558927 0.14094362558727633 1.8754961333690607e-07 6.726883826878874 0.32429428608129496 K(ub)QAELESAQCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQAELESAQCR 11 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 7605850.0 3139970.0 1716400.0 2749480.0 True False 2611024.1792565933 1707153.412521273 3324383.555840831 1.0 0.6538252024182062 1.2732105593856828 21.316184387040828 -6.755041160154133 1.6312689489027816 0.7976865337978136 1.2749253046455702 0.6703545425361671 0.1455160834043559 0.29132569577290607 1.5266922367548625 0.07042572188721936 0.17007420732658243 1.757757015069581e-07 6.755041160154133 0.47723877084775657 K(ub)QAELESAQCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQAELESAQCR 11 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 14846320.0 3360120.0 1014600.0 10471600.0 True False 4349741.577867344 958136.6180949201 8565876.247689437 1.0 0.2202743774412202 1.9692839435048097 22.05249826099728 -6.785512213335684 1.5142033959806451 0.561653526047746 1.9856562578442838 0.7864550310468066 0.3306052892765027 0.2421108561324372 1.096667189938396 0.17190307829096005 0.40382413051631977 1.6386559779522922e-07 6.785512213335684 1.4240027317965378 K(ub)QAENFAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQAENFAYR 9 1 O43255;Q8IUQ4;Q8IUQ4-2 O43255 SIAH2;SIAH1 E3 ubiquitin-protein ligase SIAH2;E3 ubiquitin-protein ligase SIAH1 1 6599940.0 857210.0 2168930.0 3573800.0 True False 1123810.6112334486 1845334.0984229234 3204017.458310279 1.0 1.642032990236282 2.851029725367765 20.099967497004098 -6.961205694579765 0.41809452204218733 0.9454512420360452 3.593075672747023 0.9998123351010657 0.010512740505930053 0.07927320337566614 0.019560470570476992 0.015621458646220408 0.10069368013320822 1.0934383591949004e-07 6.961205694579765 2.647624430710978 K(ub)QAENFAYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQAENFAYR 9 1 O43255;Q8IUQ4;Q8IUQ4-2 O43255 SIAH2;SIAH1 E3 ubiquitin-protein ligase SIAH2;E3 ubiquitin-protein ligase SIAH1 1 19294900.0 3671400.0 4623700.0 10999800.0 True False 3554853.4166227593 6469967.5222769715 8118622.393073414 1.0 1.8200377804673806 2.2838135477288968 21.761358641272544 -9.212055648746766 0.16256276653288237 8.655436901954351e-20 2.958342360694876 0.9997570356195413 0.008273727333138725 0.660852635942857 0.05840607344905992 0.654904570982268 0.3330298120235553 6.136833652104109e-10 9.212055648746766 2.958342360694876 K(ub)QAENFAYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQAENFAYR 9 1 O43255;Q8IUQ4;Q8IUQ4-2 O43255 SIAH2;SIAH1 E3 ubiquitin-protein ligase SIAH2;E3 ubiquitin-protein ligase SIAH1 1 30645400.0 5526000.0 13507400.0 11612000.0 True False 8383346.004714281 11096898.93620211 9316883.110279594 1.0 1.3236837570537936 1.1113561464647108 22.999094744148376 -10.196495599904999 3.8357997096947543 0.9998227221653447 1.2175199517167345 0.58321912799955 0.08668238438990743 20203771.512093067 28557756.774990883 40113.32653193202 0.0317225080375461 6.360692491994669e-11 10.196495599904999 0.21769722955138981 K(ub)QAENFAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQAENFAYR 9 1 O43255;Q8IUQ4;Q8IUQ4-2 O43255 SIAH2;SIAH1 E3 ubiquitin-protein ligase SIAH2;E3 ubiquitin-protein ligase SIAH1 1 8896640.0 857210.0 1730730.0 6308700.0 True False 1174143.702229219 1654260.6258412458 4818714.991754933 1.0 1.408908145315161 4.104024901386571 20.16317755852699 -6.933881592650881 0.7142182828467504 0.9643222239985919 4.7162857767497774 0.9972474988395703 0.07224473740935197 0.09067220902649456 0.06817148158999145 0.06740957855879237 0.23887172471340576 1.1644434634911387e-07 6.933881592650881 3.7519635527511856 up K(ub)QAENFAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQAENFAYR 9 1 O43255;Q8IUQ4;Q8IUQ4-2 O43255 SIAH2;SIAH1 E3 ubiquitin-protein ligase SIAH2;E3 ubiquitin-protein ligase SIAH1 1 14346100.0 3671400.0 4789000.0 5885700.0 True False 3052931.7705973866 4763200.70645793 7116372.657597944 1.0 1.560205423629852 2.330996298749722 21.54176391670682 -6.966652459228076 0.3284576166037608 0.9043881802773734 3.011988441094194 0.9999432679074383 0.004109789570115013 0.07740459934400401 0.012906371565287815 0.011309694745783128 0.06731433563856747 1.0798104864934117e-07 6.966652459228076 2.1076002608168207 K(ub)QAENFAYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQAENFAYR 9 1 O43255;Q8IUQ4;Q8IUQ4-2 O43255 SIAH2;SIAH1 E3 ubiquitin-protein ligase SIAH2;E3 ubiquitin-protein ligase SIAH1 1 42360100.0 5526000.0 9385100.0 27449000.0 True False 7153515.93374492 8862810.934834052 22453563.650524054 1.0 1.2389447394708328 3.1388150747809185 22.770221066240826 -6.930210378595255 0.7450659879325644 0.9713329018640102 3.5309428383116965 0.9965793749599015 0.05596608249372389 0.09252880919156886 0.0771468624171428 0.05105165286087702 0.17170717348803105 1.1743285552170814e-07 6.930210378595255 2.5596099364476865 up K(ub)QAVGPGGVNSGPVQIVNNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQAVGPGGVNSGPVQIVNNK 20 1 A0A0C4DGR2;M0QY25;Q86YD1-2;Q86YD1;M0QYQ4;M0QYH7;Q86YD1-3 A0A0C4DGR2 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 14702800.0 4063600.0 5901700.0 4737500.0 True False 5327418.951958381 5021189.364646424 4247308.945308904 1.0 0.94251820814667 0.7972545398832537 22.345005309233205 -6.955229950543493 0.4981316446092625 1.002956889446993 0.7305703905389838 0.9995503522705556 0.0018091359964579519 0.08145118416735073 0.027778663112040435 0.00212917884130495 0.011982253065020987 1.1085876840629568e-07 6.955229950543493 -0.27238649890800914 K(ub)QAVGPGGVNSGPVQIVNNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQAVGPGGVNSGPVQIVNNK 20 1 A0A0C4DGR2;M0QY25;Q86YD1-2;Q86YD1;M0QYQ4;M0QYH7;Q86YD1-3 A0A0C4DGR2 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 23311500.0 6540700.0 6417800.0 10353000.0 True False 6333069.058698166 8980461.008384861 7641238.7166575035 1.0 1.4180266984536714 1.2065617232079018 22.594473380626525 -10.109541393100383 4.329027449791003 0.9999577319421195 1.3122942107736908 0.7441125788780871 0.08633021473466079 30075029.899078794 1.246678295590325 13078.376912274558 0.029553128738309734 7.77067252101582e-11 10.109541393100383 0.31233647883157134 K(ub)QAVGPGGVNSGPVQIVNNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQAVGPGGVNSGPVQIVNNK 20 1 A0A0C4DGR2;M0QY25;Q86YD1-2;Q86YD1;M0QYQ4;M0QYH7;Q86YD1-3 A0A0C4DGR2 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 33284000.0 13988000.0 9458600.0 9837400.0 True False 21220818.659779817 7770638.929620901 7893033.578114404 1.0 0.36617997892554105 0.3719476474804531 24.3389769780336 -9.897512074701925 6.151019380511709 1.0000001043664317 0.3690638132037837 0.9999373290362649 0.002354640828053662 3.3689520282135717e-09 6.075417841319348e-10 0.0022798715517912418 0.0007599570593654497 1.2661580639926283e-10 9.897512074701925 -0.630936291162648 K(ub)QAVGPGGVNSGPVQIVNNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQAVGPGGVNSGPVQIVNNK 20 1 A0A0C4DGR2;M0QY25;Q86YD1-2;Q86YD1;M0QYQ4;M0QYH7;Q86YD1-3 A0A0C4DGR2 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 15700300.0 4063600.0 6209900.0 5426800.0 True False 5566022.734660884 5935526.084606819 4145101.608454304 1.0 1.0663855265349445 0.7447151774357329 22.408215370756096 -6.8528916026018605 1.221038785865302 1.0355332106816004 0.731119061545186 0.9444138028168811 0.03269241542981334 0.15430111005519995 0.4412449083380036 0.020934208237992486 0.048541658047438596 1.4031638824720715e-07 6.8528916026018605 -0.3044141491364144 K(ub)QAVGPGGVNSGPVQIVNNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQAVGPGGVNSGPVQIVNNK 20 1 A0A0C4DGR2;M0QY25;Q86YD1-2;Q86YD1;M0QYQ4;M0QYH7;Q86YD1-3 A0A0C4DGR2 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 21183100.0 6540700.0 10691000.0 3951400.0 True False 5438881.852139864 10633405.461002652 4777619.47079065 1.0 1.9550719706880677 0.8784194252925261 22.3748786560608 -6.672625605790121 1.9278817735682725 1.6082331721587386 0.8827022313089843 0.29078906373194113 0.4054493625882929 0.4551297203080652 3.2636377253219586 0.16915227607499794 0.45042106458124487 2.1250756461597927e-07 6.672625605790121 -0.7255309408497543 K(ub)QAVGPGGVNSGPVQIVNNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQAVGPGGVNSGPVQIVNNK 20 1 A0A0C4DGR2;M0QY25;Q86YD1-2;Q86YD1;M0QYQ4;M0QYH7;Q86YD1-3 A0A0C4DGR2 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 32792900.0 13988000.0 9676400.0 9128500.0 True False 18107741.744702112 9137899.833760783 7467206.6663196655 1.0 0.5046404992182039 0.41237647253856985 24.11010330012605 -13.999999999999998 0.23634161125008188 4.221646348166532 0.37014058841126896 0.9995190794936343 0.005658473576671334 13.497119778755824 0.15388770866308954 20.478695748436294 0.046073639137395116 1.0000000000000041e-14 13.999999999999998 -3.8515057597552627 K(ub)QCSALQHVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQCSALQHVK 10 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 11811400.0 3847400.0 5862100.0 2101900.0 True False 5043978.658274599 4987497.530286831 1884415.5508485013 1.0 0.9888022666600479 0.37359705076410965 22.266130740774102 -6.910844824121467 0.8899551781865251 1.0185431113045662 0.2926367134194766 0.9912365564504576 0.027399249984633344 0.10386245993185796 0.13575441248396 0.02252619678024251 0.0625531134710907 1.2278778805100602e-07 6.910844824121467 -0.7259063978850896 down K(ub)QCSALQHVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQCSALQHVK 10 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 11359400.0 3847400.0 4905800.0 2606200.0 True False 5269887.752075566 4689045.534688822 1990669.236373847 1.0 0.8897809128556909 0.3777441437134622 22.329340802296993 -6.941458304498311 0.6458619716847848 1.0056340640406485 0.23353534894724054 0.9983486424320906 0.011017289388766229 0.08710781104073732 0.05162854595776607 0.010846865530282046 0.043794656214236914 1.1443047363124201e-07 6.941458304498311 -0.772098715093408 down K(ub)QDEWIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQDEWIK 7 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 3755650.0 953650.0 1265500.0 1536500.0 True False 1250244.3851597374 1076692.3328803645 1377517.7191487332 1.0 0.8611854975399877 1.1017987647052978 20.25377869524917 -6.750261035258199 1.6486973173893629 0.9184003767253743 1.102291154775125 0.6501255898444389 0.05833193036533229 0.29961168746476446 1.6023914065777827 0.02794708134294705 0.06783421315585832 1.777210885871394e-07 6.750261035258199 0.18389077804975074 K(ub)QDPEWKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQDPEWKPK 9 2 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 7414700.0 2041700.0 3816100.0 1556900.0 True False 2643020.897923816 3603730.680378497 1273560.1751430258 1.0 1.3634892872808353 0.4818577772667069 21.333756401496945 -6.794738942338399 1.477180724392854 1.2019149955159834 0.4711978085254053 0.8163389898936441 0.15503719393061677 0.2283719140201839 0.9842439194803889 0.08258735792568592 0.1927254531538838 1.6042094031952203e-07 6.794738942338399 -0.730717186990578 down K(ub)QEDDRDGLLAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQEDDRDGLLAER 13 2 F8W120;F8VWX5;F8VVN7;F8W098;H0YIA4;A0A087WYD4;Q9BVX2-2;Q9BVX2 F8W120 TMEM106C Transmembrane protein 106C 1 16874800.0 1377600.0 6551100.0 8946100.0 True False 2089919.9160503782 5382005.021022081 7177899.413785078 1.0 2.5752206961084085 3.43453323673291 20.995016229845366 -8.860383667372542 0.23095169350910608 9.671367911640818e-15 4.150969896247137 0.9993694467774732 0.025314630782949477 0.36983684859088173 0.07325856774223426 0.6785357272224014 0.38660005363522365 1.379165334683882e-09 8.860383667372542 4.150969896247127 K(ub)QEDDRDGLLAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQEDDRDGLLAER 13 2 F8W120;F8VWX5;F8VVN7;F8W098;H0YIA4;A0A087WYD4;Q9BVX2-2;Q9BVX2 F8W120 TMEM106C Transmembrane protein 106C 1 12283600.0 1377600.0 5047200.0 5858800.0 True False 1783330.3565557364 4766318.883154628 4792558.516364538 1.0 2.6727066388081533 2.687420476383704 20.766142551937815 -10.729061500758784 0.8354691552671061 2.9110303170808496e-14 2.6840947064743506 0.9999893557463968 0.0025839759574416044 2.432551911068601 0.45313738447682694 4.962679797753721 0.002078403133876875 1.866115410156411e-11 10.729061500758784 2.6840947064743212 K(ub)QEGTPEGLYL ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQEGTPEGLYL 11 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 31645800.0 8689200.0 17426000.0 5530600.0 True False 11391625.346332503 14826108.726015987 4958346.565261299 1.0 1.301491953541924 0.43526243310465107 23.441470268307878 -6.812703321228287 1.4032799938449503 1.1637892631955769 0.41917054407954757 0.8667454494777961 0.13106368150337774 0.20313032363848732 0.7878645029275873 0.0734314495925642 0.1696523595809454 1.5392057559688147e-07 6.812703321228287 -0.7446187191160293 down K(ub)QEGTPEGLYL ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQEGTPEGLYL 11 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 42900800.0 22897000.0 14869000.0 5134800.0 True False 22170147.268184155 20806269.240810677 3789841.8393019335 1.0 0.9384813275764412 0.17094346706215363 24.402115017744375 -6.92284073845355 0.8033855100547221 1.0152653528446196 0.038709447543500454 0.9949340369908173 0.026844440788881173 0.09652949206281605 0.09716662807744303 0.023484061381172636 0.07237448118504283 1.1944260360304874e-07 6.92284073845355 -0.9765559053011191 down K(ub)QEGTPEGLYL ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQEGTPEGLYL 11 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 32806100.0 8689200.0 18588000.0 5528900.0 True False 11901832.056800706 17766720.6977039 4223087.6912698075 1.0 1.4927719205676406 0.3548266914803873 23.50468032983077 -6.78901702117185 1.5002618755237107 1.275762798730449 0.3430504083209129 0.7981210033187133 0.20935614686533535 0.23682114623135817 1.053045253536489 0.10984564663159653 0.2573604976466397 1.6254850473598035e-07 6.78901702117185 -0.932712390409536 down K(ub)QEGTPEGLYL ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQEGTPEGLYL 11 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 47053900.0 22897000.0 22052000.0 2104900.0 True False 19039870.00908873 21933201.49902074 2545024.8580420204 1.0 1.1519617249776848 0.13366818454260174 24.18252029317865 -6.868922899550806 1.1398372385633455 1.0854018226304518 0.07525501054063898 0.9635932572647401 0.0855803992587232 0.13788867909956054 0.3355090217997305 0.05830823743136933 0.1377890155276947 1.3523126184107682e-07 6.868922899550806 -1.010146812089813 down K(ub)QELAETLANLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQELAETLANLER 13 1 Q9HAF1-2;Q9HAF1;Q9HAF1-4;Q9HAF1-3 Q9HAF1-2 MEAF6 Chromatin modification-related protein MEAF6 1 15452600.0 5096100.0 5338900.0 5017600.0 True False 6681036.450702596 4542356.930869205 4498426.8842178285 1.0 0.6798880629354325 0.673312728857326 22.67164049931374 K(ub)QELAETLANLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQELAETLANLER 13 1 Q9HAF1-2;Q9HAF1;Q9HAF1-4;Q9HAF1-3 Q9HAF1-2 MEAF6 Chromatin modification-related protein MEAF6 1 17589300.0 5344800.0 5159500.0 7085000.0 True False 5175132.249595605 7219715.25643705 5229225.954556003 1.0 1.3950784073201632 1.010452622725656 22.303164300225575 -9.392092322610415 9.417806190717068 0.9999971888356156 1.2027655150229113 0.2703674186671554 0.157022819037424 0.0 0.0 0.15203669077282803 0.050678896924276 4.054223413355775e-10 9.392092322610415 0.20276832618729568 K(ub)QELAETLANLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQELAETLANLER 13 1 Q9HAF1-2;Q9HAF1;Q9HAF1-4;Q9HAF1-3 Q9HAF1-2 MEAF6 Chromatin modification-related protein MEAF6 1 18378900.0 5344800.0 10473000.0 2561100.0 True False 4444438.014786974 10416579.870272258 3096614.1688115452 1.0 2.3437338614275927 0.6967391959363324 22.08356957565985 -6.689791403202535 1.867310620337098 1.8425932135010528 0.7024581099198651 0.3694481506106262 0.5683266902611618 0.4170767350865485 2.819479164233913 0.2435048710420167 0.6342344833151277 2.0427188512042958e-07 6.689791403202535 -1.1401351035811875 K(ub)QEMLKEMPLQDPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQEMLKEMPLQDPR 14 2 Q6UW78 Q6UW78 UQCC3 Ubiquinol-cytochrome-c reductase complex assembly factor 3 1 7384190.0 2572500.0 977490.0 3834200.0 True False 2139147.731073097 972224.0673534252 4635913.492662223 1.0 0.4544913159717641 2.167177808863454 21.0286046888196 -6.821027371559923 1.367392739235508 0.7062726652484019 2.2054065338394273 0.8867330032168548 0.24042914557443526 0.19215233148377314 0.7056781373106419 0.13816086223312438 0.31835938049735557 1.509984983839272e-07 6.821027371559923 1.4991338685910254 up K(ub)QEVQAWDGEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQEVQAWDGEVR 12 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 13958400.0 5494000.0 4789700.0 3674700.0 True False 7202687.20397169 4075095.4301043656 3294477.294211422 1.0 0.565774316543593 0.45739558041543005 22.780103822068817 -13.999999999999998 0.19491372715187602 3.368593603295407 0.3833739260024488 0.9994874489570739 0.005307935835457631 12.4349009196189 0.1400042795008696 11.205903500816252 0.07172181694449294 1.0000000000000041e-14 13.999999999999998 -2.9852196772929585 K(ub)QEVQAWDGEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQEVQAWDGEVR 12 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 15837300.0 3739800.0 4060200.0 8037300.0 True False 3621082.0960630244 5681459.033663284 5932090.016168383 1.0 1.5689948150693347 1.6382092034361697 21.78798945484867 -11.530449569110774 0.3551928207002811 7.432252265177598e-22 1.6484186172522992 0.9995368156413862 0.006153923972388071 3.9933869898731005 0.18249965991048014 3.0746163379632896 0.020264601958571254 2.948155800750119e-12 11.530449569110774 1.6484186172522992 K(ub)QEVQAWDGEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQEVQAWDGEVR 12 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 51029500.0 14376000.0 11942000.0 24711500.0 True False 21809443.026379377 9810856.796728132 19827261.1935648 1.0 0.44984444512688915 0.909113596783877 24.378449590845825 -10.113615268014167 7.5107054630180565 1.0000000705475296 0.6794790209553861 0.39372157848462885 0.18749584602675395 2.2147335794067767e-07 2.629297392516893e-08 0.1815421101585312 0.06051402409539068 7.698120980151725e-11 10.113615268014167 -0.32052104959214345 K(ub)QEVQAWDGEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQEVQAWDGEVR 12 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 13475800.0 5494000.0 3873100.0 4108700.0 True False 7525280.269767426 3701973.6353710457 3138309.681332681 1.0 0.49193830696826096 0.417035587889097 22.84331388359171 -13.999999999999998 0.26959310617080984 4.912851816523595 0.39207446054725087 0.9995824539921601 0.005291755045858075 14.863084622322082 0.16436154880510445 31.86658164198441 0.031172016081126408 1.0000000000000041e-14 13.999999999999998 -4.520777355976344 K(ub)QEVQAWDGEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQEVQAWDGEVR 12 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 16559180.0 3739800.0 7981180.0 4838200.0 True False 3109809.4012311655 7938183.799199803 5849845.25069072 1.0 2.552627114721917 1.8810944646237102 21.568394730282947 -10.564738635205272 5.941237259648456 0.9968431801128269 2.216860789672807 0.8140609326449444 0.2741520563932608 0.01147180751011054 0.000840435963754866 0.26563723387377763 0.08848219572830128 2.724340362848987e-11 10.564738635205272 1.2200176095599802 K(ub)QEVQAWDGEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQEVQAWDGEVR 12 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 62949400.0 14376000.0 21019000.0 27554400.0 True False 18610015.393325537 19849274.172814034 22539781.932019357 1.0 1.0665909593999023 1.2111640670702093 24.149575912938275 -6.9584085173235595 0.4573118623679663 0.9956709129043405 1.287885929199776 0.9997065369038144 0.001509981651921762 0.08027460512008973 0.023269539173194242 0.0019546562640547238 0.011946864270138443 1.1005036382831291e-07 6.9584085173235595 0.29221501629543545 K(ub)QEYLEVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQEYLEVQR 9 1 O14964;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 2927670.0 608470.0 1077200.0 1242000.0 True False 797710.0624318623 916485.9588927127 1113489.7541052562 1.0 1.1488960739679723 1.3958577264410108 19.605504950835417 -6.9635333699738915 0.3823946364983399 0.9834862865817409 1.5700339184802519 0.99987963734557 0.001791036328212453 0.07846231547730605 0.01663738780080395 0.003206490475136959 0.020844413398528504 1.0875935667711318e-07 6.9635333699738915 0.586547631898511 K(ub)QEYLEVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQEYLEVQR 9 1 O14964;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 7319300.0 1178500.0 2689900.0 3450900.0 True False 1141089.1625782857 3763991.0976431887 2547005.765219101 1.0 3.298595080106158 2.2320830385104644 20.12198009485416 -10.659940844998093 7.140893222840886 0.9934158151971988 2.7653390593083107 0.7850902522458615 0.43540171774056624 0.045278473760085904 0.002156221373758101 0.41823558211075856 0.14052530014327635 2.1880596379993265e-11 10.659940844998093 1.771923244111112 K(ub)QEYLEVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQEYLEVQR 9 1 O14964;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 3443300.0 608470.0 907330.0 1927500.0 True False 833437.8022834698 867241.1604609257 1472264.1981085849 1.0 1.0405589452324344 1.7664955850032786 19.66871501235831 -6.918410913012665 0.8364099583082852 0.9830482152470683 1.879392093678882 0.9937286220112062 0.02788819711414607 0.09911516898079384 0.11051878925186408 0.023828752736515284 0.07033115099449198 1.2066715877993785e-07 6.918410913012665 0.8963438784318136 K(ub)QEYLEVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQEYLEVQR 9 1 O14964;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 11593300.0 1178500.0 6681900.0 3732900.0 True False 979974.9664021945 6645903.278446691 4513432.131020496 1.0 6.7817071928336645 4.605660640078151 19.902385370288435 -10.111118762777586 7.81161529816419 0.9999994655398167 5.693683916455908 0.8611767399001504 0.8883672851322207 8.27014551004243e-06 9.385417434314604e-07 0.8601580276164356 0.28671930838604887 7.742500413489874e-11 10.111118762777586 4.693684450916091 K(ub)QFSLENVQEGEILHDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQFSLENVQEGEILHDAK 18 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 52540200.0 28844000.0 6839000.0 16857200.0 True False 37814763.32569333 5818647.8582132 15112978.649680458 1.0 0.15387238598052275 0.3996581578341364 25.172446253645685 -10.135684890575634 5.161101184212853 1.0000250300395837 0.27676527198590495 0.9202852548090185 0.10034162118238255 280372871.7177241 2.089236607949853 83398.02726183088 0.034349605860965596 7.316697658354293e-11 10.135684890575634 -0.7232597580536787 K(ub)QFSLENVQEGEILHDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQFSLENVQEGEILHDAK 18 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 78487000.0 22325800.0 17406200.0 38755000.0 True False 21617079.69952507 24356586.432133853 28603902.874921374 1.0 1.126728807530324 1.3232084662920407 24.36566830349228 -6.964702219329773 0.36312654415878726 0.9836627061786842 1.473040544902528 0.9999068732535734 0.0012831726220070238 0.07806214390398616 0.01521711767324073 0.0026200654531609935 0.016750987883025457 1.0846703799841276e-07 6.964702219329773 0.48937783872384366 K(ub)QFSLENVQEGEILHDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQFSLENVQEGEILHDAK 18 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 72091500.0 23159500.0 35107000.0 13825000.0 True False 35134654.68624323 28841881.557757005 11092482.690287236 1.0 0.8208955464432066 0.3157134398884653 25.066391383610274 -6.9528281943727 0.5268817015133987 1.0081501027102897 0.10564764185637061 0.9994049425939648 0.007067819659174264 0.08236958961540838 0.03141336915252004 0.007921980271331255 0.04175964065740208 1.1147354324547706e-07 6.9528281943727 -0.902502460853919 down K(ub)QFSLENVQEGEILHDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQFSLENVQEGEILHDAK 18 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 70455500.0 28844000.0 21890000.0 19721500.0 True False 39508406.27979093 20922827.419450138 15063687.877042005 1.0 0.5295791298509664 0.3812780442309889 25.235656315168576 -13.999999999999998 0.161578489523115 3.3246535125265457 0.23800039034635828 0.9995323049400107 0.005704056261609105 12.020570239682563 0.1270794436269381 8.756583749418304 0.13084825605136666 1.0000000000000041e-14 13.999999999999998 -3.0866531221801874 K(ub)QFSLENVQEGEILHDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQFSLENVQEGEILHDAK 18 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 72847400.0 22325800.0 35324000.0 15197600.0 True False 18564891.9006382 35133702.60073494 18375347.894236982 1.0 1.892480860582181 0.989790190677345 24.146073578926558 -6.648794487601542 2.012676754538921 1.5796958298898018 0.9935772618930381 0.18912753148317973 0.38103691104540427 0.5115733842404079 3.9707197401193275 0.15360519468470027 0.42206398434795234 2.244944001938812e-07 6.648794487601542 -0.5861185679967638 K(ub)QFSLENVQEGEILHDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQFSLENVQEGEILHDAK 18 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 89109400.0 23159500.0 50061000.0 15888900.0 True False 29980429.291995153 47275061.3428443 12997283.233881446 1.0 1.576864056295113 0.43352558788581963 24.837517705702723 -6.769573841609955 1.576483000864093 1.331059961885374 0.4272577168833987 0.7287836068077844 0.2430877845649151 0.2671195726943448 1.3101748138789686 0.12155608376441587 0.2894202867307395 1.6999108990155504e-07 6.769573841609955 -0.9038022450019754 down K(ub)QFSQYIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQFSQYIK 8 1 P46777;A0A2R8Y6J3 P46777 RPL5 60S ribosomal protein L5 1 12571500.0 1749200.0 3355300.0 7467000.0 True False 2653664.28364933 2756520.499921446 5991144.177097634 1.0 1.0387600710858074 2.257687309586346 21.339554435529728 -6.913673580196347 0.8703418884754468 0.9665016100233048 2.4282494180263052 0.9922356460320821 0.051455799483306704 0.10203871796838734 0.12596031777412808 0.04290819310065388 0.12168963807083569 1.2199061473342052e-07 6.913673580196347 1.4617478080030004 up K(ub)QFSQYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQFSQYIK 8 1 P46777;A0A2R8Y6J3 P46777 RPL5 60S ribosomal protein L5 1 13084100.0 1749200.0 2650400.0 8684500.0 True False 2264373.8818868254 2502902.9101111526 7104010.110494962 1.0 1.1053399485537119 3.1372955532305613 21.110680757622177 -6.917643746808947 0.8420130848260585 0.9512466669579334 3.4478476283258286 0.9935010584593108 0.07929733290071993 0.0995782040867359 0.11294323508572555 0.06748361458645064 0.19780958166098703 1.208805015244445e-07 6.917643746808947 2.4966009613678954 up K(ub)QFSSASSQQGQEEKEEDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQFSSASSQQGQEEKEEDLK 20 2 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 8724460.0 1631020.0 1534340.0 5559100.0 True False 1579244.1628752102 2147009.963477397 4103004.940574781 1.0 1.3595174286213594 2.5980814347952066 20.590802809133724 -6.948306666756187 0.5771333750070158 0.9850304270941784 3.033528991816246 0.9990616205195892 0.020969009125678912 0.0841728906113348 0.03883179159380371 0.02203878253634767 0.10338470819414533 1.1264017933572145e-07 6.948306666756187 2.0484985647220677 up K(ub)QFSSASSQQGQEEKEEDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQFSSASSQQGQEEKEEDLK 20 2 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 43868200.0 3919800.0 7865400.0 32083000.0 True False 5946623.1757652955 6461757.917349308 25741780.987521544 1.0 1.086626430893314 4.328806488433451 22.503639227570822 -6.912630782974658 0.8776416689248256 0.9077745981716525 4.772246249007564 0.991876776331963 0.13962774340169595 0.10270361700376976 0.12952578719788158 0.11582344371156142 0.3258585453151475 1.2228388192270354e-07 6.912630782974658 3.8644716508359114 up K(ub)QFSSASSQQGQEEKEEDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQFSSASSQQGQEEKEEDLK 20 2 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 5470320.0 580600.0 1325720.0 3564000.0 True False 795263.5101250387 1267145.3068302164 2722256.602884046 1.0 1.593365331990379 3.423087527876172 19.60107345025515 -6.95083076622903 0.5496463999595189 0.9746423039162477 4.12771627833226 0.9992648833380329 0.027960360234388474 0.08315383491274583 0.034594814928134036 0.03036131083408779 0.1517808716828886 1.1198741856040918e-07 6.95083076622903 3.153073974416012 K(ub)QFSSASSQQGQEEKEEDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQFSSASSQQGQEEKEEDLK 20 2 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 5857360.0 1631020.0 1577700.0 2648640.0 True False 1356265.3964372568 1569200.6169510703 3202458.3780723168 1.0 1.1570011452575346 2.361232828386526 20.371208084568 -6.930888248516891 0.7394670517053165 0.9822778983648586 2.6141401871481214 0.9967099482778187 0.03487845854386055 0.09217909526694106 0.07544035218758047 0.03194556934287868 0.10843473034223484 1.1724970305037836e-07 6.930888248516891 1.6318622887832628 up K(ub)QFSSASSQQGQEEKEEDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQFSSASSQQGQEEKEEDLK 20 2 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 38746800.0 3919800.0 7380000.0 27447000.0 True False 5074258.370809506 6969296.512458614 22451927.63000232 1.0 1.3734611056761759 4.424671743000056 22.27476554966327 -6.92970645357145 0.749199198867151 0.953091728846491 5.046409671879249 0.9964802199195821 0.09100730945454868 0.09279052052891834 0.07842935005735632 0.08276774013441375 0.27652889925418717 1.1756919550045928e-07 6.92970645357145 4.0933179430327575 up K(ub)QGGLGPMNIPLVSDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQGGLGPMNIPLVSDPK 17 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 15582100.0 4104300.0 4330200.0 7147600.0 True False 3974011.2430802383 6059271.441694691 5275429.136596262 1.0 1.5247242826112835 1.3274821871181475 21.922164523520504 -10.102353610222693 4.438784237532876 0.9999583559537792 1.4261032348584155 0.861544960921805 0.08052374838672968 56064549.13233699 2.048278443974352 25305.94181396907 0.02756542086479412 7.900351055424342e-11 10.102353610222693 0.42614487890463626 K(ub)QGGLGPMNIPLVSDPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQGGLGPMNIPLVSDPK 17 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 16037100.0 4104300.0 7860200.0 4072600.0 True False 3412907.3013190744 7817855.542472457 4924161.830425159 1.0 2.2906732742055103 1.442805618694065 21.70256979895478 -10.070940416260784 4.906610438276923 0.9999760472757637 1.8667394464568499 0.5821753331677594 0.3461405209265588 9.069891519756028e-05 1.717382948871802e-05 0.33515835216596956 0.11171637274619522 8.4929698772789e-11 10.070940416260784 0.8667633991810861 K(ub)QGGLGPMNIPLVSDPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQGGLGPMNIPLVSDPK 17 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 18304800.0 4027800.0 5235100.0 9041900.0 True False 5214066.499807772 4943762.082977247 7396366.977728641 1.0 0.9481586173017759 1.4185409752639948 22.31397755233786 -6.879563080383578 1.0821987709530543 0.9680491232166396 1.4516031937674259 0.9733327859390549 0.03438913788853938 0.12801940750273552 0.27461174579849384 0.02448757279719531 0.059153746121785096 1.3195836309684127e-07 6.879563080383578 0.48355407055078625 K(ub)QGLEQFINK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQGLEQFINK 10 1 O60493;O60493-2;O60493-4 O60493 SNX3 Sorting nexin-3 1 1593500.0 0.0 1593500.0 0.0 True False 0.0 2229792.859992721 0.0 0.0 K(ub)QGLEQFINK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQGLEQFINK 10 1 O60493;O60493-2;O60493-4 O60493 SNX3 Sorting nexin-3 1 2958400.0 0.0 1615600.0 1342800.0 True False 0.0 1606896.44212851 1623573.2715942925 0.0 K(ub)QGLEQFINK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQGLEQFINK 10 1 O60493;O60493-2;O60493-4 O60493 SNX3 Sorting nexin-3 1 19289500.0 2428800.0 4210700.0 12650000.0 True False 3144129.478805581 3976370.8434972237 10347829.79996098 1.0 1.2646969122301546 3.2911589264103727 21.584229199956436 -6.9309243452838665 0.7391691191910476 0.970215875580029 3.7171408026631845 0.9967167316197005 0.058640296732495156 0.09216084382695232 0.0753507075222608 0.05372073044886128 0.18243701746379418 1.1723995814340153e-07 6.9309243452838665 2.7469249270831555 up K(ub)QIDQQNCTC ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQIDQQNCTC 10 1 Q14145;K7EQX2 Q14145 KEAP1 Kelch-like ECH-associated protein 1 1 5853400.0 1128400.0 2348600.0 2376400.0 True False 1479343.3274411445 1998198.0347710985 2130512.9240384344 1.0 1.35073312442449 1.4401747616786384 20.49652548269117 -12.420035760837541 0.21633599210669555 1.522389210564836e-06 1.4934737837904861 0.99940654567386 0.004627625862741723 6.383955522894538 0.13651269566104665 2.836888766799879 0.050603073422580074 3.801580919129311e-13 12.420035760837541 1.4934722614012756 K(ub)QIDQQNCTC ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQIDQQNCTC 10 1 Q14145;K7EQX2 Q14145 KEAP1 Kelch-like ECH-associated protein 1 1 24652900.0 3242400.0 3779500.0 17631000.0 True False 4918957.851191747 3105018.6956317187 14146225.122058168 1.0 0.6312350683955233 2.8758581695573735 22.229921262495363 -6.864738901085171 1.161647785553952 0.7968168914064246 2.994768083744231 0.9591397525928194 0.19866354704117828 0.1419944776446529 0.36145916327136396 0.1331117693322068 0.31255551357495137 1.3654037739998108e-07 6.864738901085171 2.197951192337807 up K(ub)QIDQQNCTC ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQIDQQNCTC 10 1 Q14145;K7EQX2 Q14145 KEAP1 Kelch-like ECH-associated protein 1 1 5258100.0 1128400.0 1699600.0 2430100.0 True False 1545599.9738634068 1624506.0521743929 1856160.429480505 1.0 1.0510520701638932 1.2009319751997771 20.55973554421406 -6.9519356145821485 0.537171682294023 0.9977513883525029 1.261120687666109 0.9993445669211811 0.0021831128484010413 0.08271764892252 0.032816524249838976 0.002410613005025324 0.012406736733210477 1.1170288382740231e-07 6.9519356145821485 0.2633692993136061 K(ub)QIDQQNCTC ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQIDQQNCTC 10 1 Q14145;K7EQX2 Q14145 KEAP1 Kelch-like ECH-associated protein 1 1 13639800.0 3242400.0 5447000.0 4950400.0 True False 4197350.717259236 5143869.661702177 4049477.9953934243 1.0 1.2255038971489602 0.9647699866351963 22.001047584587813 -6.677887459831367 1.9089381834953674 1.1429419090849515 0.9657662855182636 0.31473210824782205 0.09561715942446723 0.44320354962869946 3.1205590261743033 0.04021510523300748 0.10637026211687894 2.0994838593509072e-07 6.677887459831367 -0.17717562356668792 K(ub)QLADETLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQLADETLLK 10 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 102834000.0 38633000.0 46624000.0 17577000.0 True False 50648237.12250424 39667880.93892861 15758300.65048962 1.0 0.7832035860000981 0.3111322633475791 25.59400871924226 -6.95834886710024 0.4581168450476014 1.014021867241839 0.06134405974265207 0.999703954648658 0.004948323277393409 0.08029638412214941 0.023351713213931462 0.00639099710699591 0.039006090804945624 1.10065480252516e-07 6.95834886710024 -0.952677807499187 down K(ub)QLADETLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQLADETLLK 10 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 140402000.0 79334000.0 38737000.0 22331000.0 True False 76815585.59523605 54204886.1107863 16481841.184359927 1.0 0.7056495851819422 0.21456376406745897 26.194895722289665 -7.206235980286173 0.448407822549289 1.0185530137119105 9.439157705009209e-15 0.9994456939419423 0.007627889986526477 0.08887745682814364 0.03136092973094702 0.009912964473462583 0.04660550837685036 6.219622410170759e-08 7.206235980286173 -1.018553013711901 down K(ub)QLADETLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQLADETLLK 10 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 191736000.0 114570000.0 55989000.0 21177000.0 True False 173811066.18894565 45997325.50594635 16991356.667791154 1.0 0.26463979834255097 0.0977576229198219 27.372944697566915 -13.99999999992981 0.2093521235591411 5.244816836917515 5.54569093473175e-12 0.9994869976595432 0.008877563014708729 12.754082098146526 0.1452848040505298 22.26152185634719 0.0988727158101411 1.0000000001616166e-14 13.99999999992981 -5.244816836911969 K(ub)QLADETLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQLADETLLK 10 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 99940000.0 38633000.0 33397000.0 27910000.0 True False 52916664.11756916 31921410.11088968 21318232.824493166 1.0 0.6032392752492362 0.4028642617593723 25.657218780765152 -11.777998541582765 0.11239687486365546 2.2224548616616127 7.548098699903123e-15 0.9998110137609774 0.0034111678168701025 5.000892523300566 0.07766753192315431 1.7701636577537032 0.29374842210980917 1.667252811392988e-12 11.777998541582765 -2.222454861661605 K(ub)QLADETLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQLADETLLK 10 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 141419200.0 79334000.0 52856000.0 9229200.0 True False 65969736.09211003 52571254.23690546 11158983.049000604 1.0 0.7968995686674116 0.1691530648753833 25.97530099772394 -7.063576540839016 0.6013406488880927 1.0039602398522456 6.195825505147777e-14 0.9989305873399705 0.011565053737022919 0.07514641237893739 0.04181682346799684 0.01200870509510471 0.04602490786670395 8.63820406009121e-08 7.063576540839016 -1.0039602398521836 down K(ub)QLADETLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQLADETLLK 10 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 209335000.0 114570000.0 84051000.0 10714000.0 True False 148313123.5123334 79373487.963233 8764161.934923481 1.0 0.5351750815000027 0.05909228885058626 27.144071019659364 -7.842368791058851 0.5117691424786471 1.0205614073454865 3.9193109892469565e-21 0.9941865198823439 0.029288683562276544 0.10999178995388774 0.11316160751027704 0.036210738465464215 0.07761938759793025 1.437577308254386e-08 7.842368791058851 -1.0205614073454865 down K(ub)QLAEEETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQLAEEETK 9 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 6253600.0 2209800.0 2869900.0 1173900.0 True False 2897069.1997336387 2441722.1067825803 1052436.088843929 1.0 0.8428249166457867 0.3632761305600473 21.46616271472649 -6.951070834339145 0.5469629155755974 1.0067545688148178 0.1769350766576083 0.9992826501712864 0.007253458572588853 0.08305861406300134 0.03420493913366463 0.007903815801819364 0.039760358082120334 1.1192553156939388e-07 6.951070834339145 -0.8298194921572095 down K(ub)QLAEEETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQLAEEETK 9 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 5155600.0 1582900.0 2205500.0 1367200.0 True False 1532651.7059356538 3086167.651530557 1009089.3048791775 1.0 2.0136131644120097 0.6583944029626406 20.547598452094224 -6.706523300385158 1.807453241393725 1.6253700982332142 0.6618848255505916 0.44850782203903017 0.4273751835617138 0.3821786794915595 2.431540156947368 0.18831525180408518 0.48046300769877937 1.965516525589459e-07 6.706523300385158 -0.9634852726826226 K(ub)QLAEEETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQLAEEETK 9 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 5255200.0 2209800.0 1981800.0 1063600.0 True False 3026822.7775995685 1894237.5230637856 812399.5855295926 1.0 0.6258171231835439 0.2684001163007861 21.52937277624938 -7.542799148984551 0.3028944331294731 1.0888562777158397 2.2400589568210673e-13 0.9996487110318398 0.005598453013598984 0.12530617024880708 0.034002095810119926 0.02490727295945106 0.06808925368826617 2.8655028914133398e-08 7.542799148984551 -1.0888562777156157 down K(ub)QLAQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQLAQIK 7 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 8675900.0 2093600.0 4819700.0 1762600.0 True False 2744729.8744512424 4100619.547043456 1580223.0600530787 1.0 1.4939974914155436 0.5757299014239114 21.388232741153633 -6.760594432812714 1.6104072319195808 1.2867273004607551 0.5722926995348245 0.6933521062690181 0.2077928378662601 0.2819039377564618 1.441076235776638 0.10180416057568951 0.2444909698346505 1.7354238719933526e-07 6.760594432812714 -0.7144346009259306 K(ub)QLAQIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQLAQIK 7 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 8396200.0 3274500.0 4302700.0 819000.0 True False 3170552.789870681 6020790.548284084 604479.3305266585 1.0 1.8989718662055954 0.19065423936729775 21.59630296731594 -6.7637139219516165 1.5983991071895312 1.5197540185509895 0.18322083445612375 0.7059776997181162 0.3783400140406238 0.2767224818733839 1.3941722531682863 0.18668302127136424 0.44701553115528414 1.7230031762680408e-07 6.7637139219516165 -1.3365331840948658 K(ub)QLAQIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQLAQIK 7 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 9749610.0 3274500.0 5726800.0 748310.0 True False 2722891.8349461067 5695948.591719208 904778.1612054837 1.0 2.091874718861885 0.3322857520792381 21.376708242750215 -6.738886796240529 1.6909547322753298 1.650496291516301 0.33153746229804587 0.5998817841546655 0.45877058850096664 0.31982159159726153 1.7951792277961613 0.21467880803876682 0.5274104507600971 1.824371183291506e-07 6.738886796240529 -1.3189588292182552 K(ub)QLEALMAEHQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQLEALMAEHQR 12 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 20054200.0 7813200.0 9759200.0 2481800.0 True False 10243180.863136431 8303165.401063656 2225007.143106622 1.0 0.8106041972709298 0.21721837902072655 23.28816045600205 -6.964127881898083 0.5591963238794068 1.0075192884598214 6.046716747542234e-18 0.9992423010182652 0.009178765860700473 0.08088270344214288 0.03530576886144476 0.009929217669870389 0.04770689459210866 1.0861057629615312e-07 6.964127881898083 -1.0075192884598214 down K(ub)QLEALMAEHQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQLEALMAEHQR 12 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 36216100.0 11718000.0 15266000.0 9232100.0 True False 11346018.5041089 21361793.41113829 6813936.052936702 1.0 1.8827567929139397 0.6005574599115162 23.435682786211938 -6.7214394344555215 1.7540111470568593 1.5362294010724946 0.6023768970744386 0.519342750812623 0.3714035105174848 0.35253620128940905 2.1203954602572255 0.16807377277928384 0.4212352437103019 1.899155674794919e-07 6.7214394344555215 -0.933852503998056 K(ub)QLEALMAEHQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQLEALMAEHQR 12 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 39769700.0 11718000.0 26239000.0 1812700.0 True False 9744036.195418673 26097645.298966262 2191727.1890221685 1.0 2.678319823076655 0.2249301157206956 23.216088061646214 -6.72255250607759 1.7499750366837679 2.018273178705833 0.2281561291381537 0.5245823945573249 0.7060320570424413 0.3503933573735514 2.0983923220194707 0.32016769306058956 0.8013850061451854 1.8942944808555025e-07 6.72255250607759 -1.7901170495676793 K(ub)QLIREK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQLIREK 7 2 H0Y883;H0Y896;Q96MT7 H0Y883 CFAP44 Cilia- and flagella-associated protein 44 2 20168500.0 4291700.0 9815700.0 6061100.0 True False 5626460.260881918 8351235.821298926 5433955.514176625 1.0 1.4842788243544645 0.9657858159874182 22.423796143471968 -6.661576348752199 1.9679067700399593 1.311327068531993 0.9679672446468313 0.24213842902432126 0.2061189255432039 0.48067438336811835 3.580274702811974 0.08458547183813346 0.22844721003799973 2.1798351495730596e-07 6.661576348752199 -0.34335982388516184 K(ub)QLIREK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQLIREK 7 2 H0Y883;H0Y896;Q96MT7 H0Y883 CFAP44 Cilia- and flagella-associated protein 44 2 52463000.0 22387000.0 12327000.0 17749000.0 True False 21676336.939024262 17249235.38445577 13100004.441413505 1.0 0.7957633908800196 0.6043458578017098 24.36961764201009 -6.971907240292585 0.2076380569101586 1.1032880059427208 0.29149168719713076 0.999993683871018 0.00040597346031577043 0.07568854621427128 0.006768658546305992 0.005841047098728028 0.019945330445461863 1.0668239567539881e-07 6.971907240292585 -0.8117963187455901 K(ub)QLIREK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQLIREK 7 2 H0Y883;H0Y896;Q96MT7 H0Y883 CFAP44 Cilia- and flagella-associated protein 44 2 63996700.0 4291700.0 38518000.0 21187000.0 True False 5878457.468831601 36816147.398007326 16183066.959961912 1.0 6.262892534854877 2.7529444664296348 22.48700620499486 -9.684893158178609 6.863520029421902 0.9999999973918434 4.507918500643338 0.5711452499686638 1.4329302985554488 7.684904671145521e-08 1.204880283646884e-08 1.3874287956435791 0.46247626521452767 2.0658883274147873e-10 9.684893158178609 3.507918503251495 K(ub)QLLCGAAIGTHEDDKYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQLLCGAAIGTHEDDKYR 18 2 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 6881500.0 2045700.0 1272800.0 3563000.0 True False 1980760.3732595674 1781035.677564315 2629743.412291186 1.0 0.8991676638973837 1.327643387758027 20.91762292697679 -6.844688099046584 1.26056714049688 0.9463485952749721 1.3430843606838545 0.9321955571210043 0.04762878896453825 0.16339869353684353 0.5023447632580665 0.02960286599117025 0.06830509425720802 1.4299205279965685e-07 6.844688099046584 0.39673576540888245 K(ub)QLQAIEFNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQLQAIEFNK 10 1 O76094;O76094-2 O76094 SRP72 Signal recognition particle subunit SRP72 1 6961400.0 2195700.0 1564900.0 3200800.0 True False 2125998.705365416 2189772.7308456907 2362414.4580582716 1.0 1.0299972080506574 1.1112022091529075 21.019709287659108 -6.9537346852813515 0.5162174004355452 0.9985786618675438 1.1462213277990534 0.9994627004942725 0.0010888565332479315 0.08201986064971686 0.030017394244123505 0.0012410976872672427 0.006705233791687645 1.112411102492827e-07 6.9537346852813515 0.14764266593150954 K(ub)QLQAIEFNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQLQAIEFNK 10 1 O76094;O76094-2 O76094 SRP72 Signal recognition particle subunit SRP72 1 6426000.0 2195700.0 3007100.0 1223200.0 True False 1825821.8360027997 2990900.1554373875 1478965.4645622096 1.0 1.6381117239704222 0.8100272630105305 20.800114563093384 -6.700902571259529 1.827681693909521 1.395894291325226 0.8124522305461982 0.42182770734554853 0.26931117254125175 0.3936593107713648 2.557156283240968 0.11752665881292747 0.3019077976731753 1.9911199726904824e-07 6.700902571259529 -0.5834420607790277 K(ub)QLQALSSELAQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQLQALSSELAQAR 14 1 A0A2R8Y5S7;P35241;P35241-5;P35241-4;P35241-2;A0A2R8Y4H6 A0A2R8Y5S7 RDX Radixin 1 13099300.0 5784300.0 4460000.0 2855000.0 True False 5600680.562665743 6240901.258592742 2107189.8518359074 1.0 1.1143112321375235 0.3762381782461368 22.41717071519556 -6.867358439404832 1.1480508904058817 1.063718179732536 0.3351419376156761 0.9619710311633122 0.06325393520688186 0.13940888122195086 0.3450809433213355 0.042826279201957945 0.10094808636145663 1.3571928424310348e-07 6.867358439404832 -0.7285762421168598 down K(ub)QLQALSSELAQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQLQALSSELAQAR 14 1 A0A2R8Y5S7;P35241;P35241-5;P35241-4;P35241-2;A0A2R8Y4H6 A0A2R8Y5S7 RDX Radixin 1 14409400.0 5784300.0 6429300.0 2195800.0 True False 4809901.737938238 6394664.084783865 2654931.627767907 1.0 1.329479152213395 0.5519721134481932 22.197575990629836 -6.791577870176787 1.490112517839916 1.183766474294631 0.5433493695920301 0.8063807950332267 0.14021006102184055 0.23300070445416085 1.0220401896773128 0.07405770074820238 0.17318332494191654 1.6159284597802556e-07 6.791577870176787 -0.6404171047026009 K(ub)QLQDEMLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQLQDEMLR 9 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 12081000.0 2860300.0 6896600.0 2324100.0 True False 3749880.9991845977 5867654.162736249 2083624.4263414077 1.0 1.564757432039085 0.5556508131309998 21.838413382369936 -6.75482318767068 1.6318059494679928 1.3301502503787743 0.5528631116623531 0.6695026017941121 0.23739609442506257 0.29172314120548287 1.5296765943776347 0.11485103048301896 0.2774508926804212 1.7586394550812011e-07 6.75482318767068 -0.7772871387164212 K(ub)QLQDEMLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQLQDEMLR 9 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 17362100.0 7925400.0 6938900.0 2497800.0 True False 7673812.515144623 9709638.95588546 1843551.2476062076 1.0 1.2652953061757817 0.24023928705162842 22.871512087095834 -6.837997991128151 1.2916909262347138 1.141187437057004 0.20784492845946118 0.9209515946186579 0.12213493185725784 0.17115048164455623 0.5555690572223768 0.07416722882034305 0.170783426314155 1.452118334488414e-07 6.837997991128151 -0.9333425085975429 down K(ub)QLQDEMLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQLQDEMLR 9 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 28641600.0 15019500.0 10100000.0 3522100.0 True False 22785679.572530974 8297576.088339826 2825955.391208733 1.0 0.36415749909618134 0.12402330956218363 24.44162406313784 -9.8869543677222 0.2556774951886679 1.5186603583956713 2.8198686169942128e-24 0.9990346920733613 0.01148258669794262 1.3329591703854238 0.11393544772294237 0.6109705618320275 0.10272442483288102 1.297315575627941e-10 9.8869543677222 -1.5186603583956713 K(ub)QLQDEMLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQLQDEMLR 9 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 10591200.0 2860300.0 4922500.0 2808400.0 True False 3917830.206701078 4705007.673469306 2145113.7608135683 1.0 1.2009217922261755 0.5475259640258412 21.901623443892827 -6.824150925614194 1.3538534716040889 1.1078633010868795 0.5319547014145062 0.8936633326034629 0.08910746519117098 0.18813824940596835 0.6764376771170009 0.05170612715273589 0.1190610822489336 1.4991637569715636e-07 6.824150925614194 -0.5759085996723733 K(ub)QLQDEMLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQLQDEMLR 9 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 19100600.0 7925400.0 11175200.0 0.0 True False 6590321.254750909 11114996.979496466 0.0 1.0 1.6865637576444024 0.0 22.65191736253011 -6.809158793444848 1.503941252990158 1.3798838964310045 2.8361579803078864e-18 0.8202743934259191 0.29357411188808225 0.2184683466229277 0.987693607071232 0.15549103427468308 0.34638552517455223 1.5518195060393796e-07 6.809158793444848 -1.3798838964310045 K(ub)QLQDEMLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQLQDEMLR 9 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 32316600.0 15019500.0 16031000.0 1266100.0 True False 19443038.82860692 15138860.757618433 1035682.7912830514 1.0 0.7786262677902147 0.05326753705594782 24.21275038523029 -7.2358663368876135 0.7427142215922536 0.9940439892981411 1.0755823932311636e-17 0.9939380830547948 0.031481619823916035 0.09341272869756118 0.0958020622975185 0.027844237369009116 0.062076633180533684 5.809431872954947e-08 7.2358663368876135 -0.9940439892981411 down K(ub)QLSSTVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQLSSTVFK 9 1 Q9BXW9;Q9BXW9-1;Q9BXW9-3;H7BZJ7 Q9BXW9 FANCD2 Fanconi anemia group D2 protein 1 319147000.0 88937000.0 125780000.0 104430000.0 True False 116597268.26713306 107014114.28659996 93624585.36329478 1.0 0.9178097898607935 0.8029740898285358 26.796958747434676 -6.966410503693466 0.3329621375096579 1.0135161328754647 0.7034917598374206 0.9999393282120803 0.0006293626475324478 0.07748559490658237 0.013190051264005485 0.001658408302132105 0.009992669970728644 1.08041224158507e-07 6.966410503693466 -0.3100243730380441 K(ub)QLSSTVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQLSSTVFK 9 1 Q9BXW9;Q9BXW9-1;Q9BXW9-3;H7BZJ7 Q9BXW9 FANCD2 Fanconi anemia group D2 protein 1 286946000.0 71466000.0 100860000.0 114620000.0 True False 69197350.94851054 141133923.97795156 84597583.47370635 1.0 2.0395856494993385 1.222555232448928 26.044213473076432 -10.161463736293268 4.500532590269302 0.9999023594430825 1.6310704409893848 0.44303944907691983 0.3335512711028304 38307657.03943058 86492466.79343961 24428.07798931815 0.11418347628818139 6.895031644680501e-11 10.161463736293268 0.6311680815463023 K(ub)QLSSTVFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQLSSTVFK 9 1 Q9BXW9;Q9BXW9-1;Q9BXW9-3;H7BZJ7 Q9BXW9 FANCD2 Fanconi anemia group D2 protein 1 588760000.0 265710000.0 168190000.0 154860000.0 True False 403101496.003009 138175180.42553213 124251853.1224507 1.0 0.34278012310949274 0.3082396229100653 28.586567896473248 -13.633104420285724 0.4229501691042551 9.999999999992141 0.3072150626735954 0.9998623801874421 0.0037336703817393052 21.993815472178127 0.21690023536732328 181.0745920049613 0.008321430468495244 2.327531566621891e-14 13.633104420285724 -9.692784937318546 K(ub)QLSSTVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQLSSTVFK 9 1 Q9BXW9;Q9BXW9-1;Q9BXW9-3;H7BZJ7 Q9BXW9 FANCD2 Fanconi anemia group D2 protein 1 270057000.0 88937000.0 99912000.0 81208000.0 True False 121819412.33205394 95497557.47519882 62028342.93125918 1.0 0.783927254671798 0.5091827463605146 26.860168808957567 -6.9678574667776685 0.3050527989217946 1.0448771894918083 0.23956153737105446 0.9999605168744055 0.0012620520630594425 0.07700422356401007 0.011505491471836968 0.0044477318230457625 0.02451193809654237 1.0768185619742937e-07 6.9678574667776685 -0.8053156521207538 K(ub)QLSSTVFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQLSSTVFK 9 1 Q9BXW9;Q9BXW9-1;Q9BXW9-3;H7BZJ7 Q9BXW9 FANCD2 Fanconi anemia group D2 protein 1 369045000.0 71466000.0 214760000.0 82819000.0 True False 59427145.48061023 213603045.25347745 100136069.98820944 1.0 3.5943682558868897 1.685022377877491 25.82461874851071 -6.567507302086696 2.316646036420588 2.77979729928382 1.6887739529462313 0.0 1.13063283774113 0.7377146438290342 7.429231962205319 0.4131311853692465 1.2683081536665408 2.7070276884523103e-07 6.567507302086696 -1.0910233463375885 K(ub)QLSSTVFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQLSSTVFK 9 1 Q9BXW9;Q9BXW9-1;Q9BXW9-3;H7BZJ7 Q9BXW9 FANCD2 Fanconi anemia group D2 protein 1 604060000.0 265710000.0 223690000.0 114660000.0 True False 343966832.92713714 211241454.86068663 93793056.51095065 1.0 0.6141332088999236 0.27268052478425714 28.357694218565697 -7.6443812888094484 0.28561053753966337 1.1092415906199475 1.4830258341934618e-11 0.9996464913306958 0.005586234206472651 0.12712458670782642 0.03647609291948963 0.032504331685938054 0.0749167338514565 2.26787289874432e-08 7.6443812888094484 -1.1092415906051172 down K(ub)QQDSTYPIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQQDSTYPIK 10 1 P46977;P46977-2;H0YET6 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 2752540.0 805750.0 536190.0 1410600.0 True False 780171.907295252 750293.4631939112 1041121.542907087 1.0 0.9617027429186407 1.3344770981520102 19.573432524663538 -6.881561365739104 1.071024552190362 0.975734658298889 1.3617023736920717 0.9749243867492317 0.026513383060866917 0.12625729104862712 0.26398948321516996 0.01904149975858451 0.04623654551808091 1.3135258808550958e-07 6.881561365739104 0.38596771539318275 K(ub)QQDSTYPIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQQDSTYPIK 10 1 P46977;P46977-2;H0YET6 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 3437160.0 861400.0 1216160.0 1359600.0 True False 1179882.8584597101 1162426.0298966852 1038490.4818409515 1.0 0.9852046087136022 0.8801640556051973 20.170212201870346 -6.932390874844839 0.7269298793544852 1.0014643095882274 0.8572276498888953 0.99698708711912 0.0029282088647199834 0.09141580107964072 0.07174488327992469 0.0027067021586862027 0.009382576899012285 1.1684472886768064e-07 6.932390874844839 -0.14423665969933208 K(ub)QQDSTYPIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQQDSTYPIK 10 1 P46977;P46977-2;H0YET6 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 3195690.0 805750.0 978440.0 1411500.0 True False 670016.8257773176 973168.9495148655 1706638.1239613795 1.0 1.4524544937895358 2.547157113526857 19.353837800097814 -6.956159458914778 0.48655018591808896 0.9752770776294909 3.07048419811148 0.9996001771662947 0.012987347044894623 0.08110266975126777 0.02642575114399143 0.01564585446891527 0.0902897114307826 1.1062175420299101e-07 6.956159458914778 2.095207120481989 up K(ub)QQELMDENFDLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQQELMDENFDLSK 14 1 Q13137-5;Q13137-2;Q13137;Q13137-3;Q13137-4;D6REB0;H0Y9G3 Q13137-5 CALCOCO2 Calcium-binding and coiled-coil domain-containing protein 2 1 14830600.0 4949700.0 4394900.0 5486000.0 True False 4792574.4828288 6149806.489100733 4049052.023527774 1.0 1.2831947653885667 0.8448594879505839 22.192369422745557 -6.732259937292883 1.7147521327354662 1.1699926253838266 0.8449990762715313 0.5698102072811781 0.11902879818046158 0.33202062078142985 1.9135526541075896 0.05498272132991931 0.13610059942070288 1.8524225652633297e-07 6.732259937292883 -0.3249935491122954 K(ub)QQELMDENFDLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQQELMDENFDLSK 14 1 Q13137-5;Q13137-2;Q13137;Q13137-3;Q13137-4;D6REB0;H0Y9G3 Q13137-5 CALCOCO2 Calcium-binding and coiled-coil domain-containing protein 2 1 29975000.0 5131000.0 14060000.0 10784000.0 True False 7784102.126346167 11550883.148718601 8652537.673204891 1.0 1.4839069376573748 1.1115652817451362 22.8920992075273 -10.714557930061849 6.306261173810978 0.9952819881310024 1.2977361097010474 0.4602027279162887 0.15200784449465532 0.010195186263163273 0.00046146709168131853 0.14881536554719463 0.04906032085172389 1.9294879467548775e-11 10.714557930061849 0.3024541215700449 K(ub)QQELMDENFDLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQQELMDENFDLSK 14 1 Q13137-5;Q13137-2;Q13137;Q13137-3;Q13137-4;D6REB0;H0Y9G3 Q13137-5 CALCOCO2 Calcium-binding and coiled-coil domain-containing protein 2 1 9325600.0 2004000.0 3498900.0 3822700.0 True False 2744932.956063691 3344307.0286849686 2919856.990977788 1.0 1.2183565435713943 1.0637261593321181 21.38833948171106 -10.120614792658797 4.395001633058323 0.9999822474970536 1.1410413514571993 0.5259050336555933 0.06312759005293564 1.1909219598843876e-05 2.382831964685121e-06 0.06113136615843728 0.02037434207535869 7.575044829193986e-11 10.120614792658797 0.14105910396014576 K(ub)QQISLATQMVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQQISLATQMVR 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 4800100.0 1433700.0 1823900.0 1542500.0 True False 1879594.5839705514 1551781.229506515 1382896.896704797 1.0 0.8255935842443498 0.7357421161447992 20.84199008507322 -13.999999999963887 0.08457613740108373 1.9164931735299138 0.48874540133191113 0.9998671154417856 0.001264654942072778 12.213950354131548 0.0831256043055312 2.053517718592015 0.22312111381685432 1.000000000083154e-14 13.999999999963887 -1.4277477721980025 K(ub)QQISLATQMVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQQISLATQMVR 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 8463600.0 2480200.0 2676200.0 3307200.0 True False 2401467.4085928407 3744820.6161986296 2440945.1061266954 1.0 1.5593884817254038 1.0164389895080803 21.19548479856136 -10.449524305842749 3.3564796466427365 0.9959217605410526 1.2879137358323547 0.27268770662195185 0.22165820280369855 122885381.80649573 174582174.82407743 4779980.514901334 0.08761812570536075 3.552022385812125e-11 10.449524305842749 0.29199197529130205 K(ub)QQISLATQMVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQQISLATQMVR 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 5182300.0 1433700.0 1752900.0 1995700.0 True False 1963777.6342856856 1675451.0819348595 1524356.762731676 1.0 0.8531775964259296 0.776236950720825 20.905200146596112 -13.999999825785988 0.08140175296574512 1.7851511362181878 0.5523169485620781 0.9998808220099126 0.0010133303717385017 12.244641429982071 0.08068099329060403 1.7202578324001534 0.20300826634282848 1.0000004011426678e-14 13.999999825785988 -1.2328341876561097 K(ub)QQISLATQMVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQQISLATQMVR 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 8872800.0 2480200.0 4941900.0 1450700.0 True False 2062396.1914897934 4915277.003809657 1754034.6627210577 1.0 2.383284561953664 0.8504838546341634 20.975890073995636 -6.669000358348268 1.9411965840865142 1.8837105452861187 0.8567401897284634 0.2745457611985951 0.5877259160048908 0.4633910399692481 3.3655748641697905 0.24384246855185854 0.6522698381637279 2.1428888329630808e-07 6.669000358348268 -1.0269703555576553 K(ub)QQQQEGNYLQHVQLDQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQQQQEGNYLQHVQLDQR 18 1 Q9BYM8-3;Q9BYM8;G3XAG9 Q9BYM8-3 RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1 1 26282500.0 9076200.0 10238000.0 6968300.0 True False 11898986.094045836 8710530.307411425 6247287.160653515 1.0 0.7320397081369907 0.525026847773157 23.504335311743866 -7.141299721984439 0.1407911955415762 1.2862082273584305 2.585589910087627e-13 0.999998249210823 0.00025721099512477085 0.08220155766922797 0.005365477192597634 0.015405225882709402 0.03204557392105804 7.222711666771512e-08 7.141299721984439 -1.286208227358172 K(ub)QQQQEGNYLQHVQLDQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQQQQEGNYLQHVQLDQR 18 1 Q9BYM8-3;Q9BYM8;G3XAG9 Q9BYM8-3 RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1 1 46730000.0 16287000.0 10555000.0 19888000.0 True False 15769978.100053076 14769666.54359785 14678736.172788985 1.0 0.936568614736893 0.9308025718018963 23.910677320854433 -13.999999999879341 0.3393512455485114 1.730753958889643 0.9298899093280377 0.9997338736948355 0.0005113822660858918 19.645446201775343 0.1868323758150651 10.294994677766676 0.0017857203394798277 1.0000000002778277e-14 13.999999999879341 -0.8008640495616053 K(ub)QQQQEGNYLQHVQLDQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQQQQEGNYLQHVQLDQR 18 1 Q9BYM8-3;Q9BYM8;G3XAG9 Q9BYM8-3 RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1 1 79462000.0 18911000.0 38367000.0 22184000.0 True False 28689369.579289097 31520109.087260764 17799322.676407408 1.0 1.0986685852454277 0.6204152596387746 24.774012930860255 -6.852911035087135 1.2209369924711195 1.05281479673432 0.6001927440020361 0.9444397847323189 0.04859624465914407 0.15428204402328907 0.4411056935967838 0.031120284336205953 0.07216222258146861 1.403101099377652e-07 6.852911035087135 -0.45262205273228384 K(ub)QQQQEGNYLQHVQLDQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQQQQEGNYLQHVQLDQR 18 1 Q9BYM8-3;Q9BYM8;G3XAG9 Q9BYM8-3 RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1 1 23760300.0 9076200.0 5833800.0 8850300.0 True False 12431916.41508247 5576043.426203201 6760041.417650018 1.0 0.4485264572273277 0.5437650312262957 23.567545373266757 -10.560670105318795 6.486234474593344 1.000712374266079 0.4961457442268117 0.9739028655757976 0.038880985021294806 0.00040105528045784194 2.7164472770633354e-05 0.03769529610943323 0.012548783955967901 2.7499822755401604e-11 10.560670105318795 -0.5045666300392674 K(ub)QQQQEGNYLQHVQLDQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQQQQEGNYLQHVQLDQR 18 1 Q9BYM8-3;Q9BYM8;G3XAG9 Q9BYM8-3 RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1 1 39298500.0 16287000.0 15077000.0 7934500.0 True False 13543362.136438312 14995777.208449816 9593567.265017066 1.0 1.1072418397573371 0.7083593548167517 23.69108259628871 -6.83512624636558 1.304695895966148 1.057135285180409 0.6964453585092574 0.9157638858057304 0.0489171631765664 0.17457333922974438 0.5793125896547925 0.029419720513098185 0.06771939158581447 1.461752191560947e-07 6.83512624636558 -0.36068992667115163 K(ub)QQQQEGNYLQHVQLDQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQQQQEGNYLQHVQLDQR 18 1 Q9BYM8-3;Q9BYM8;G3XAG9 Q9BYM8-3 RBCK1 RanBP-type and C3HC4-type zinc finger-containing protein 1 1 61157600.0 18911000.0 32547000.0 9699600.0 True False 24480662.291539997 30735730.83888759 7934372.326300523 1.0 1.2555105933351 0.3241077480588618 24.545139252952705 -6.8335696395992045 1.3118172358348805 1.1362271067600038 0.2971535237146627 0.9128441688638397 0.116004845931974 0.17644211018494518 0.5925420836435425 0.06940412276461451 0.1597304246859243 1.4670008328449681e-07 6.8335696395992045 -0.8390735830453411 down K(ub)QTIDNSQGAYQEAFDISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQTIDNSQGAYQEAFDISK 19 1 P27348 P27348 YWHAQ 14-3-3 protein theta 1 41356000.0 10633000.0 17862000.0 12861000.0 True False 13764628.10776506 16867963.998040088 10520429.96500381 1.0 1.225457300115819 0.7643090596155595 23.71446229598802 -6.773745294471901 1.56014545784708 1.1286887807070045 0.7613386472918244 0.7447527533687959 0.09512202920301051 0.26037032995933634 1.2512227347015712 0.04804458907022991 0.11397640328404796 1.6836612071354053e-07 6.773745294471901 -0.3673501334151801 K(ub)QTLGQNDTGFSCDGTANTFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQTLGQNDTGFSCDGTANTFR 21 1 Q9H0C5 Q9H0C5 BTBD1 BTB/POZ domain-containing protein 1 1 10171400.0 3663700.0 2832400.0 3675300.0 True False 4803146.179321269 2409816.960608727 3295015.211967033 1.0 0.5017163481268975 0.6860118532625319 22.195548285659793 -10.067894583172572 5.06177274655277 1.0000077725868532 0.5938641006930877 0.8662240001160596 0.07523832491745132 6.599641889490525e-06 1.2151654404427266e-06 0.07285058807746629 0.02428306494934205 8.552742894587754e-11 10.067894583172572 -0.40614367189376555 K(ub)QTLGQNDTGFSCDGTANTFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQTLGQNDTGFSCDGTANTFR 21 1 Q9H0C5 Q9H0C5 BTBD1 BTB/POZ domain-containing protein 1 1 29528900.0 6636800.0 15381000.0 7511100.0 True False 10068510.815071976 12636140.377698481 6026527.792767915 1.0 1.2550158220799557 0.5985520503932471 23.263346981261748 -6.801371058089967 1.4503165867155556 1.1404638176885034 0.5891829754135599 0.8361159880549485 0.10938943981648488 0.21882163142943326 0.9085467755872877 0.05933187166346709 0.137869922391866 1.5798976092695686e-07 6.801371058089967 -0.5512808422749435 K(ub)QTLGQNDTGFSCDGTANTFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQTLGQNDTGFSCDGTANTFR 21 1 Q9H0C5 Q9H0C5 BTBD1 BTB/POZ domain-containing protein 1 1 10464000.0 3663700.0 3572100.0 3228200.0 True False 5018268.897769728 3414272.810644944 2465765.6468659583 1.0 0.6803686450844337 0.49135781623057706 22.258758347182685 -9.90444978138878 0.10535622405639565 1.7662792015750126 3.2478418001706866e-15 0.9999214864242724 0.0018600677525235088 1.4669471656372708 0.047733870472420656 0.5595772057080305 0.2560220788714467 1.246092317866813e-10 9.90444978138878 -1.7662792015750093 K(ub)QTLGQNDTGFSCDGTANTFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQTLGQNDTGFSCDGTANTFR 21 1 Q9H0C5 Q9H0C5 BTBD1 BTB/POZ domain-containing protein 1 1 23233000.0 6636800.0 10029000.0 6567200.0 True False 8591468.430886408 9470877.33380048 5372036.985162358 1.0 1.1023583930952465 0.6252757637855987 23.034473303354197 -6.850577587367787 1.2323174692229935 1.0546486982621341 0.6059916865375802 0.9411435978255397 0.04975198921267889 0.15681850084466675 0.4579844067706603 0.03158728137460376 0.0731215565018694 1.4106601973616998e-07 6.850577587367787 -0.44865701172455397 K(ub)QVEIAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQVEIAQR 8 1 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 1 7747900.0 1398900.0 2975000.0 3374000.0 True False 1833971.4469668723 2531141.596459176 3024890.8456933484 1.0 1.3801423139086073 1.6493663795562834 20.80653974716665 -6.974840776673275 0.08230157732525115 0.09436447630416496 2.941907795845308 0.9999998865453343 8.95418530204103e-05 0.07476069872488496 0.002390336103252355 0.031255918280358674 0.05108909097803936 1.0596421455461848e-07 6.974840776673275 2.847543319541143 K(ub)QVEIAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQVEIAQR 8 1 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 1 10232200.0 2609500.0 3544200.0 4078500.0 True False 2526662.850868084 4959417.542758834 3010218.4976226785 1.0 1.9628331263329928 1.1913811518574629 21.26880173822451 -10.27457162283454 4.836710526784149 0.9998211168728077 1.5771071390959093 0.4273158509187883 0.31494394975695567 0.0006076972720514695 9.11450944858186e-05 0.30503645829775444 0.10164772269945528 5.3140835365156905e-11 10.27457162283454 0.5772860222231015 K(ub)QVEIAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQVEIAQR 8 1 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 1 6126200.0 1398900.0 2294700.0 2432600.0 True False 1916111.133851047 2193312.5664418535 1858069.9809696188 1.0 1.1446687656543597 0.9697088796907225 20.86974980868954 -6.687055226023334 1.876385293275019 1.09094228604709 0.9703251704716316 0.35696507977397807 0.06122095346572242 0.4229926980867742 2.8849690074707572 0.026120988225976565 0.06828686283858428 2.0556291801749927e-07 6.687055226023334 -0.12061711557545851 K(ub)QVEIAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQVEIAQR 8 1 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 1 8510200.0 2609500.0 4044400.0 1856300.0 True False 2169914.87045102 4022612.0144494553 2244443.74743855 1.0 1.8538109808950014 1.0343464520209675 21.049207013658787 -10.387325978347706 4.319095712343658 0.9989970894928322 1.4440787164606161 0.28138205330072685 0.3345449930174764 0.0032377774547793963 0.0004592857628484991 0.3246204889283269 0.10797393220824406 4.098963222293636e-11 10.387325978347706 0.44508162696778397 K(ub)QVEVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQVEVFR 7 1 A0A087X1Z3;Q9UL46;H0YLG1;H0YLD2 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 1 1866480.0 631650.0 478170.0 756660.0 True False 828099.2669073003 406828.89989206166 678368.0815952357 1.0 0.4912803526700902 0.8191869123719127 19.659444192995846 -10.187035063051606 7.1370276393806495 1.0000005437154431 0.6552336325210045 0.5957911958495921 0.13386729243015572 1.1581595129373845e-06 1.3179325556933247e-07 0.1296166532678897 0.04320548284865594 6.500772038122876e-11 10.187035063051606 -0.3447669111944386 K(ub)QVEVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQVEVFR 7 1 A0A087X1Z3;Q9UL46;H0YLG1;H0YLD2 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 1 2817960.0 588960.0 1029200.0 1199800.0 True False 570263.7871804046 1440164.9272070962 885536.3867715304 1.0 2.525436402559954 1.5528539715803282 19.121269896213327 -9.92629174207234 5.5710149725148135 0.9999989159946482 2.0391451870723745 0.6035023551511103 0.3970551147904944 5.345915405371901e-06 1.0303644009537972e-06 0.38444736270685653 0.1281489872580279 1.1849724625169863e-10 9.92629174207234 1.0391462710777262 K(ub)QVEVFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQVEVFR 7 1 A0A087X1Z3;Q9UL46;H0YLG1;H0YLD2 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 1 6412700.0 1067900.0 3847600.0 1497200.0 True False 1620082.3739475873 3160965.718563989 1201277.7637539278 1.0 1.951114196040412 0.7414917803388134 20.627635738893566 -6.697038672211169 1.8415869191051817 1.5923091232571158 0.745299725472109 0.4035017297476655 0.40169823402786653 0.40169474945384315 2.6464715600834587 0.17416170372863296 0.44951639325461523 2.0089139187807282e-07 6.697038672211169 -0.8470093977850068 K(ub)QVEVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQVEVFR 7 1 A0A087X1Z3;Q9UL46;H0YLG1;H0YLD2 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 1 2658240.0 588960.0 1547300.0 521980.0 True False 489746.3353519187 1538964.3877849965 631123.6046371671 1.0 3.142370400136098 1.288674481216196 18.901675171647604 -6.611091681406831 2.15020587993789 2.4302973187017476 1.295419717706733 0.053683660745226125 0.9233957269133921 0.6095812180332779 5.342506156793171 0.3544842866554154 1.0246663538319412 2.4485462887761283e-07 6.611091681406831 -1.1348776009950146 K(ub)QVEVFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQVEVFR 7 1 A0A087X1Z3;Q9UL46;H0YLG1;H0YLD2 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 1 3767380.0 1067900.0 1902000.0 797480.0 True False 1382417.6014560603 1796152.0280076277 652346.8228358021 1.0 1.2992832456095704 0.4718883947576363 20.398762060986016 -6.808853038269067 1.4193485622243445 1.1633303082228506 0.45779076728208123 0.8568064911240099 0.1294392085369124 0.20837270066869815 0.8275591213717186 0.07171234666595627 0.1659733307044937 1.5529124140249943e-07 6.808853038269067 -0.7055395409407693 down K(ub)QVVNIPSFIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQVVNIPSFIVR 12 1 P46781 P46781 RPS9 40S ribosomal protein S9 1 7274900.0 2123400.0 1894400.0 3257100.0 True False 2783797.9630348533 1611762.9043133657 2920086.536309368 1.0 0.578979841825966 1.0489577818089697 21.408623079251985 -6.67050779852135 1.9351911792646528 0.7313925184682422 1.0470798569342064 0.2815082330776445 0.17881724208958563 0.4599236885731927 3.320996444743583 0.07437009273934066 0.19859437446645362 2.135463739695407e-07 6.67050779852135 0.3156873384659642 K(ub)QVVNIPSFIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQVVNIPSFIVR 12 1 P46781 P46781 RPS9 40S ribosomal protein S9 1 11083800.0 2475300.0 3167200.0 5441300.0 True False 2396722.95641072 4431879.476729811 4016060.294499026 1.0 1.849141330613738 1.6756464420541082 21.19263172298704 -10.059173265096836 4.608795556167976 0.9999655177530219 1.7623938862673705 0.9626124256666461 0.07082899176043193 49103803.507068925 1.3527589846071322 18323.89151745779 0.02424664780509891 8.726231592656587e-11 10.059173265096836 0.7624283685143486 K(ub)QVVNIPSFIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQVVNIPSFIVR 12 1 P46781 P46781 RPS9 40S ribosomal protein S9 1 29390200.0 1805900.0 4093300.0 23491000.0 True False 2739682.3289745795 3362818.633901128 18847993.553528942 1.0 1.2274483790826138 6.879627376573785 21.38557718915871 -6.915374517389239 0.8583168137983024 0.8533164894704608 7.700750102805055 0.9927969044502782 0.23082027412746262 0.10097065574360588 0.12027770679006815 0.194148799202057 0.5581748918533526 1.2151376648130846e-07 6.915374517389239 6.847433613334594 up K(ub)QVVNIPSFIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQVVNIPSFIVR 12 1 P46781 P46781 RPS9 40S ribosomal protein S9 1 7882900.0 2123400.0 2264200.0 3495300.0 True False 2908478.362727366 2164160.1572918687 2669782.1279631318 1.0 0.7440867310638928 0.9179308885968808 21.471833140774876 -10.06918959644417 4.865381374051992 1.0000050016864201 0.831008810086623 0.5575085583779474 0.07097158012588037 3.850620326999695e-06 7.366599962728286e-07 0.0687199704159828 0.02290597898928851 8.52727764254437e-11 10.06918959644417 -0.16899619159979717 K(ub)QVVNIPSFIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQVVNIPSFIVR 12 1 P46781 P46781 RPS9 40S ribosomal protein S9 1 8029100.0 2475300.0 3868900.0 1684900.0 True False 2058321.6243829906 3848057.4677834734 2037204.7999026065 1.0 1.8695122386118739 0.9897407556573117 20.973036998421318 -10.200634478687691 4.8150051046209015 0.9999465812385189 1.4296264969955292 0.24125525772119394 0.35916520394500806 0.00023457875767223904 3.894346318138974e-05 0.34780929260459603 0.11592007111354359 6.300362259341615e-11 10.200634478687691 0.42967991575701037 K(ub)QVVNIPSFIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQVVNIPSFIVR 12 1 P46781 P46781 RPS9 40S ribosomal protein S9 1 17690600.0 1805900.0 4742700.0 11142000.0 True False 2337773.1496109227 4478764.575831635 9114270.326574337 1.0 1.9158251417923244 3.8986974968427677 21.15670351125116 -6.958464048832273 0.45656507475576336 0.9401772151084987 4.9538201245833156 0.9997089242594006 0.020640656834632773 0.08025441597835907 0.023193529709234374 0.02677603825063346 0.16387042103782012 1.1003629302544141e-07 6.958464048832273 4.013642909474817 K(ub)QYPISLVLAPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQYPISLVLAPTR 13 1 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;A0A2R8YDH3;O15523-3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 1 7036400.0 1853400.0 1963100.0 3219900.0 True False 1794564.83149987 2746976.067431261 2376511.595070554 1.0 1.5307198821763268 1.3242829422241056 20.775202613065424 -10.142931817540477 4.573709012864453 0.9999513595402576 1.4275014122061713 0.8511446763592359 0.08427752786672439 58913806.04037 2.906589263118855 31890.031677657913 0.028850439433081375 7.195619374210774e-11 10.142931817540477 0.4275500526659137 K(ub)QYPISLVLAPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQYPISLVLAPTR 13 1 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;A0A2R8YDH3;O15523-3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 1 5179700.0 1853400.0 2028500.0 1297800.0 True False 1541184.2195416451 2017572.0678742738 1569163.9796507806 1.0 1.3091050649832818 1.0181547148967414 20.5556078884997 -10.451849407161461 3.4525627416968954 0.9979089294067962 1.1636298899090165 0.29662760114013353 0.11877998329438717 13959476.32395138 15094938.27706183 192641.9540217812 0.0406615469152894 3.533056582892601e-11 10.451849407161461 0.1657209605022203 K(ub)RDPGSAPSLGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KRDPGSAPSLGDR 13 2 P28340;M0R2B7;A0A087WYJ2;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 5520200.0 1397900.0 1525100.0 2597200.0 True False 1914741.4068270626 1457716.0391687255 1983794.8510130283 1.0 0.7613122241840069 1.036064109722469 20.868718133130066 -6.677043602179109 1.9125696697339867 0.8485768832454872 1.0349904140704744 0.3105285266891705 0.10122825908647698 0.4451481558902531 3.14561504294965 0.04251190967641547 0.11254144589870076 2.1035672357940467e-07 6.677043602179109 0.18641353082498724 K(ub)RDPGSAPSLGDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KRDPGSAPSLGDR 13 2 P28340;M0R2B7;A0A087WYJ2;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 8454400.0 2186600.0 4129000.0 2138800.0 True False 1818254.7828044433 4106756.257457668 2586013.1913061254 1.0 2.258625301743181 1.422250179547173 20.79412294054714 -10.113265370149877 4.717047633528829 0.9999587830105835 1.8404377406587895 0.5738002915960034 0.3414487139550036 0.00019813210315598257 3.724558658576418e-05 0.3306278799965818 0.110202098541424 7.704325621361497e-11 10.113265370149877 0.840478957648206 K(ub)SAASIACFLAANGADLSIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSAASIACFLAANGADLSIR 20 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 9905200.0 1822400.0 3893700.0 4189100.0 True False 1764548.9095313256 5448474.715377256 3091849.039693802 1.0 3.087743664087159 1.7522036498920368 20.75086798842474 -10.121843892264081 5.2123536299701065 0.999962414527791 2.419973656991045 0.6011567617310651 0.5452319276462936 190174685.65300053 6.184182954577042 85787.09191741633 0.18664739115166604 7.553636953695337e-11 10.121843892264081 1.4200112424632538 K(ub)SAASIACFLAANGADLSIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSAASIACFLAANGADLSIR 20 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 5759500.0 1822400.0 1973900.0 1963200.0 True False 1515406.3460087897 1963266.2089115256 2373696.0431887945 1.0 1.2955378034956033 1.5663759422946395 20.531273263859017 -6.972168776047869 0.19970473671649194 0.8381751680386692 2.031213995270792 0.9999947236762732 0.000531259685373108 0.07560505111992541 0.006445839011695496 0.008814632430686352 0.02877428441649931 1.0661816998847187e-07 6.972168776047869 1.1930388272321228 K(ub)SADTLWGIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSADTLWGIQK 11 1 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 1 19776800.0 4849100.0 7994500.0 6933200.0 True False 4695167.974763146 11186745.540766751 5117186.928458388 1.0 2.382608162454738 1.0898836752941798 22.16274534211756 -6.6303168362097695 2.079567006285396 1.9106819039360021 1.0951157402023697 0.11857142774061413 0.5930197890866988 0.5581539921887967 4.600427514065539 0.2332163152671189 0.6568202531493103 2.3425192248447884e-07 6.6303168362097695 -0.8155661637336324 K(ub)SADTLWGIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSADTLWGIQK 11 1 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 1 21464700.0 7873200.0 9214800.0 4376700.0 True False 10784134.805229854 8807659.66673134 3343013.6009659353 1.0 0.8167238100974029 0.3099936769470569 23.362407100118894 -6.953270206507693 0.5217116107982297 1.0084981880614459 0.09553957115949394 0.9994335424769193 0.006945620861954882 0.0821986255852792 0.030729333274152785 0.007847233849444007 0.04186339577511588 1.1136014647146547e-07 6.953270206507693 -0.9129586169019519 down K(ub)SADTLWGIQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSADTLWGIQK 11 1 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 1 17274500.0 14154900.0 0.0 3119600.0 True False 18323797.084792975 0.0 2551864.8097990775 1.0 0.0 0.1392650659680621 24.127215156062228 -10.141942189948475 4.112633467616422 1.0002729561107517 0.06963253284147838 0.9834728114180054 0.05685472570841327 215454912.79872984 407176736.828458 783080.1849054965 0.020161722825542443 7.212034740364748e-11 10.141942189948475 -0.9306404232692733 K(ub)SAPSTGGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSAPSTGGVK 10 1 K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 K7EK07 H3F3B;H3F3A Histone H3;Histone H3.3 1 4870500.0 1661400.0 2040500.0 1168600.0 True False 2178111.489020487 1736065.3538067036 1047684.4820027404 1.0 0.7970507306710114 0.4810059022616386 21.054646371193684 -6.964627128348282 0.36439489892685056 1.0259021764627094 0.24124956956270324 0.9999052511591792 0.0020786544953260854 0.07808771733406639 0.015307468679676249 0.004204674339354268 0.026924951269120995 1.0848579393675118e-07 6.964627128348282 -0.7846526069000062 down K(ub)SAPSTGGVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSAPSTGGVK 10 1 K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 K7EK07 H3F3B;H3F3A Histone H3;Histone H3.3 1 9728700.0 3094000.0 3849900.0 2784800.0 True False 2995782.663569978 5387185.146963269 2055377.337790767 1.0 1.7982563329689392 0.6860902704275081 21.51450153305303 -6.714085041117838 1.7809558874967066 1.488689560171492 0.688408415321183 0.4843967910588761 0.3361733742872879 0.36689252311510284 2.270945423543876 0.15008496004210453 0.37936500990659766 1.9315900468169405e-07 6.714085041117838 -0.800281144850309 K(ub)SAPSTGGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSAPSTGGVK 10 1 K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 K7EK07 H3F3B;H3F3A Histone H3;Histone H3.3 1 3567660.0 1661400.0 953110.0 953150.0 True False 2275664.477646813 910998.4486867121 728035.6007404389 1.0 0.40032195327350917 0.319922206411235 21.117856432716575 -13.999999999999998 0.2831823301961794 5.974080948804691 0.29646804772911817 0.9996122402165276 0.005974865225352421 15.57302689740233 0.16862411141278927 44.94604391725399 0.03133086649762895 1.0000000000000041e-14 13.999999999999998 -5.677612901075572 K(ub)SAPSTGGVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSAPSTGGVK 10 1 K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 K7EK07 H3F3B;H3F3A Histone H3;Histone H3.3 1 9741100.0 3094000.0 5525000.0 1122100.0 True False 2572798.087440299 5495235.728373361 1356725.9219957946 1.0 2.1358985593154816 0.5273347833314095 21.294906808487305 -6.716990978236492 1.7703249070077431 1.693280129671268 0.5302829299255861 0.49822536292245256 0.4781742761075361 0.3611822191897549 2.2105905146736133 0.21461481444912878 0.5406424425208803 1.918708598315603e-07 6.716990978236492 -1.162997199745682 K(ub)SAPSTGGVK(ub)K(ub)PHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSAPSTGGVKKPHR 14 3 K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 K7EK07 H3F3B;H3F3A Histone H3;Histone H3.3 3 2403390.0 548810.0 316780.0 1537800.0 True False 719495.2246836001 269517.65879876865 1378683.2076192135 1.0 0.374592699926938 1.9161811785832115 19.45662558621385 -6.79657045940839 1.4698180211400553 0.653414181201841 1.9357135528365155 0.8219453905889208 0.26713418450325205 0.22570024904365796 0.962940285270312 0.14300172830976135 0.33329634369963734 1.5974583383364375e-07 6.79657045940839 1.2822993716346744 K(ub)SAPSTGGVK(ub)K(ub)PHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSAPSTGGVKKPHR 14 3 K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 K7EK07 H3F3B;H3F3A Histone H3;Histone H3.3 3 5599520.0 688200.0 917520.0 3993800.0 True False 666353.467701635 1283890.5208035905 2947703.968568215 1.0 1.926740961117745 4.4236341693175865 19.34592813345361 -6.95383874865933 0.5149790393483793 0.955864157822108 5.504987750605494 0.999469121429608 0.033313769630935706 0.08197993419057585 0.02985901643601386 0.03804921812050268 0.20615108266570198 1.1121445842801786e-07 6.95383874865933 4.549123592783386 K(ub)SAPSTGGVK(ub)K(ub)PHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSAPSTGGVKKPHR 14 3 K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 K7EK07 H3F3B;H3F3A Histone H3;Histone H3.3 3 3904130.0 773100.0 2141900.0 989130.0 True False 1172849.2211807119 1759661.2102589158 793628.0219489199 1.0 1.5003302883958587 0.6766667084026124 20.1615861250293 -6.742302539856419 1.678574965154394 1.2969002611353813 0.6759660742021371 0.6151260348791794 0.21020860643529135 0.3136551788293937 1.7361779487127533 0.09904153003880259 0.24239843929697522 1.810078709473185e-07 6.742302539856419 -0.6209341869332442 K(ub)SAPSTGGVK(ub)K(ub)PHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSAPSTGGVKKPHR 14 3 K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 K7EK07 H3F3B;H3F3A Histone H3;Histone H3.3 3 9599010.0 548810.0 2232800.0 6817400.0 True False 751719.8880325913 2134147.5131177814 5207270.528760298 1.0 2.8390196229918745 6.92714215981277 19.51983564773674 -6.957926008039579 0.46373909949466713 0.8851853087127336 9.046814146838816 0.9996853768941619 0.043938464172237894 0.08045047641420301 0.023932933483042883 0.0558826983682363 0.33759110445791 1.1017269978494773e-07 6.957926008039579 8.161628838126083 K(ub)SAPSTGGVK(ub)K(ub)PHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSAPSTGGVKKPHR 14 3 K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 K7EK07 H3F3B;H3F3A Histone H3;Histone H3.3 3 6464900.0 688200.0 3029300.0 2747400.0 True False 572268.7924293516 3012980.5596310305 3321868.6374576697 1.0 5.264974430705117 5.804734910243712 19.126333408887888 -9.75144122956731 0.5403475864085069 4.027303622804936e-21 5.773223948491426 0.9990257608294106 0.06707875108040397 1.034944658811706 0.24445934634970906 2.0243740639052925 0.10170967168688774 1.772387875386357e-10 9.75144122956731 5.773223948491426 K(ub)SASPEVSEGHENQHGQESEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSASPEVSEGHENQHGQESEAK 22 1 O60930 O60930 RNASEH1 Ribonuclease H1 1 5164540.0 994040.0 1310500.0 2860000.0 True False 1361563.4509209325 1252597.7767560245 2184526.9035489233 1.0 0.919970182740139 1.604425340641566 20.376832785048503 -6.877754781150757 1.0921927690978532 0.9517236738459978 1.6509009799569754 0.9718311370564213 0.0512812097030246 0.129639967206912 0.2844333212644378 0.03623735421595232 0.08715633128415638 1.3250895189292646e-07 6.877754781150757 0.6991773061109776 K(ub)SASPEVSEGHENQHGQESEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSASPEVSEGHENQHGQESEAK 22 1 O60930 O60930 RNASEH1 Ribonuclease H1 1 4129600.0 1249500.0 1395100.0 1485000.0 True False 1039014.6122355034 1387584.3193943328 1795506.634135775 1.0 1.3354810443029868 1.7280860278496304 19.98678451312497 -6.969054044515552 0.27986235835749607 0.9133637968752049 2.1621644777763653 0.9999740333864711 0.001516200660665104 0.0766108780965499 0.010124315589794194 0.007257636302563173 0.03604245717916518 1.0738557711632995e-07 6.969054044515552 1.2488006809011605 K(ub)SCEMGLQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSCEMGLQLR 10 1 Q9NPD3;E9PI41 Q9NPD3 EXOSC4 Exosome complex component RRP41 1 9008800.0 2959500.0 4610700.0 1438600.0 True False 3879933.1598387677 3922801.532367833 1289747.472025621 1.0 1.0110487399558312 0.3324148687342895 21.887600368437674 -6.903202503765251 0.9408247279801067 1.025789777195219 0.2563671932743427 0.9880926591965823 0.03462826447626082 0.10908547181515042 0.16443365564770454 0.027430372194758017 0.0725849932142341 1.2496761926415644e-07 6.903202503765251 -0.7694225839208761 down K(ub)SCEMGLQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSCEMGLQLR 10 1 Q9NPD3;E9PI41 Q9NPD3 EXOSC4 Exosome complex component RRP41 1 7059600.0 2959500.0 2386100.0 1714000.0 True False 4053707.127480282 2280674.212222473 1309188.500938062 1.0 0.5626144515378699 0.3229608010068138 21.950810429960566 -9.414017795685423 0.16625388008261255 1.5443262120338557 2.4792153921862776e-22 0.9997184047612341 0.004703685404156165 0.8466498793095347 0.063601063280698 0.3933819201990094 0.16938594423143297 3.8546256259737205e-10 9.414017795685423 -1.5443262120338557 K(ub)SCEMGLQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSCEMGLQLR 10 1 Q9NPD3;E9PI41 Q9NPD3 EXOSC4 Exosome complex component RRP41 1 4532950.0 1934100.0 2248000.0 350850.0 True False 1608289.8451578133 2235889.577806937 424211.1128528875 1.0 1.3902280018360376 0.2637653369074539 20.617096001021 -6.813125141473322 1.4011780435695784 1.2118931011048053 0.24257628387043897 0.8679005224907655 0.16975231917167038 0.20254846322496978 0.7831171807446923 0.09524197198095631 0.22003760127109287 1.537711486599455e-07 6.813125141473322 -0.9693168172343664 down K(ub)SCEMGLQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSCEMGLQLR 10 1 Q9NPD3;E9PI41 Q9NPD3 EXOSC4 Exosome complex component RRP41 1 13160700.0 5593700.0 3742400.0 3824600.0 True False 7241154.91831142 3534132.1501660054 3128562.043709944 1.0 0.4880619445426997 0.43205290854894457 22.78778838569891 -13.999999999999998 0.31245571805240135 6.020302951970032 0.4199728608930144 0.9996773805935408 0.0045901998674400925 17.446520940937837 0.17794970897189374 57.02155170543669 0.019215958972361225 1.0000000000000041e-14 13.999999999999998 -5.6003300910770175 K(ub)SDGIYIINLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSDGIYIINLK 11 1 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 1 7909500.0 1711600.0 3955300.0 2242600.0 True False 2243924.175157976 3365184.6576386467 2010557.2645382034 1.0 1.4996873311914527 0.8960005363802709 21.097592495729085 -6.68693029923326 1.8774653832043464 1.3141760629761663 0.8981704537949261 0.3559939743546432 0.21146731045903783 0.4233229038965191 2.8906115099226284 0.09019035693823063 0.23576246249395164 2.0562205763465e-07 6.68693029923326 -0.4160056091812402 K(ub)SDGIYIINLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSDGIYIINLK 11 1 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 1 23892600.0 3244800.0 2388800.0 18259000.0 True False 4922598.82665525 1962499.9762204103 14650100.646796012 1.0 0.39867152399129524 2.976090711976684 22.230988739451863 -6.84524178803685 1.2577177459860143 0.6799585481405206 3.070107116396738 0.933103459258205 0.28476419987880014 0.16277320926283556 0.4978675352208191 0.1773573825550659 0.4093855608625235 1.42809866102551e-07 6.84524178803685 2.3901485682562176 up K(ub)SDGIYIINLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSDGIYIINLK 11 1 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 1 6019000.0 1711600.0 0.0 4307400.0 True False 2344424.774250801 0.0 3290080.8336876384 1.0 0.0 1.403363788773746 21.160802557251976 -6.71534102897009 1.7758685885009475 0.3886146361858181 1.4006597059420964 0.4905606936530209 0.4210609999003549 0.3644371190286957 2.243478605992444 0.18844359557088688 0.4757136341532527 1.926011921793082e-07 6.71534102897009 1.0120450697562784 K(ub)SDGIYIINLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSDGIYIINLK 11 1 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 1 15648200.0 3244800.0 2917900.0 9485500.0 True False 4200457.56457031 2755516.2999597536 7759236.329449004 1.0 0.6560038418675543 1.8472359761222212 22.002115061544313 -6.8294771727616315 1.330347907761925 0.816127218481729 1.8789269480358184 0.9048057846658325 0.15444514456699737 0.1814576121098544 0.6282837313703253 0.09115972766123771 0.20977752537133212 1.4808900912615675e-07 6.8294771727616315 1.0627997295540894 K(ub)SDLFQEDLYPPTAGPDPALTAEEWLGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSDLFQEDLYPPTAGPDPALTAEEWLGGR 29 1 P31146 P31146 CORO1A Coronin-1A 1 50758000.0 10719000.0 8509000.0 31530000.0 True False 16261506.663867587 6990502.468879561 25298081.67991004 1.0 0.42988036799887525 1.5557034291368192 23.95495759664231 -6.769050678953435 1.5782748569479612 0.6725971101334969 1.5617830879908394 0.7268564845450951 0.24021594448423017 0.26796302407611755 1.3171882835256812 0.11998421683028902 0.2858399126758429 1.70195989067722e-07 6.769050678953435 0.8891859778573425 K(ub)SDLFQEDLYPPTAGPDPALTAEEWLGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSDLFQEDLYPPTAGPDPALTAEEWLGGR 29 1 P31146 P31146 CORO1A Coronin-1A 1 39347000.0 10719000.0 6901000.0 21727000.0 True False 13875956.803078488 6516953.283533465 17772908.937846024 1.0 0.46965793970240877 1.2808420485932162 23.72608391873476 -6.730276067743409 1.7220182847199217 0.6809487748810564 1.2804041695442363 0.5606640885256226 0.22293793006134047 0.33570655402435823 1.9503379977910185 0.102584944227322 0.254498002843572 1.8609038408507941e-07 6.730276067743409 0.5994553946631799 K(ub)SDPVVSYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSDPVVSYR 9 1 P13639 P13639 EEF2 Elongation factor 2 1 4099200.0 1085000.0 1796900.0 1217300.0 True False 1422445.5071549467 1528809.524261342 1091345.473166128 1.0 1.0747754599887172 0.7672318325564144 20.4399419543248 -6.842448642215457 1.2709488403741105 1.0397746886640387 0.7566142977291735 0.9285901048737771 0.03499604388222339 0.16595486028396236 0.5196601485832766 0.021582020113750964 0.04975900360090381 1.437313013718945e-07 6.842448642215457 -0.2831603909348651 K(ub)SDPVVSYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSDPVVSYR 9 1 P13639 P13639 EEF2 Elongation factor 2 1 5865600.0 1499000.0 1570200.0 2796400.0 True False 1451415.0655111156 2197189.0484848255 2063938.949798223 1.0 1.5138254388389483 1.4220184141959469 20.46902871955185 -10.039717910891119 4.817615326315253 0.9999891188453583 1.4679219265245973 0.9719388635971807 0.03748006089170686 25933646.3908715 1.0594116438945673 3182.802543140336 0.012830421750089948 9.126034139937779e-11 10.039717910891119 0.46793280767923895 K(ub)SDPVVSYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSDPVVSYR 9 1 P13639 P13639 EEF2 Elongation factor 2 1 26430800.0 0.0 8749800.0 17681000.0 True False 0.0 7188329.82750057 14186342.600142399 0.0 K(ub)SDPVVSYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSDPVVSYR 9 1 P13639 P13639 EEF2 Elongation factor 2 1 2648700.0 1085000.0 0.0 1563700.0 True False 1486153.8210225066 0.0 1194386.2654123954 1.0 0.0 0.8036760720977263 20.503152015847693 -9.74114173703324 10.330909239457759 1.0000000053351454 0.4018380193307772 0.42482735304739294 0.3280993825206094 0.0 0.0 0.3176808611008146 0.10589362036693818 1.8149232448896402e-10 9.74114173703324 -0.5981619860043683 K(ub)SDPVVSYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSDPVVSYR 9 1 P13639 P13639 EEF2 Elongation factor 2 1 2951600.0 1499000.0 0.0 1452600.0 True False 1246484.9169596005 0.0 1756331.9439364506 1.0 0.0 1.4090278350262417 20.249433994986127 -6.716069349746712 1.773317645714033 0.3890804402687489 1.4063839131509261 0.493980614146717 0.4210184346754329 0.3630058733972632 2.228680467505605 0.1886679323744944 0.47585606841927464 1.9227846670379837e-07 6.716069349746712 1.0173034728821773 K(ub)SDPVVSYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSDPVVSYR 9 1 P13639 P13639 EEF2 Elongation factor 2 1 32099800.0 0.0 9348200.0 22751600.0 True False 0.0 8827964.45227178 18611042.251129825 0.0 K(ub)SDVEAIFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSDVEAIFSK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 12957200.0 2442900.0 7855800.0 2658500.0 True False 3202665.5570772514 6683745.261668564 2383423.9221327114 1.0 2.0869320079016123 0.7442000669928899 21.610841719813273 -6.691378701904782 1.8619415299421405 1.6805687419263164 0.7488136559146947 0.3767314964003814 0.45956914883221334 0.4136904992509797 2.7818187924388527 0.19739586134293186 0.5130606044136372 2.0352665647688677e-07 6.691378701904782 -0.9317550860116217 K(ub)SDVEAIFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSDVEAIFSK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 12510600.0 3774900.0 3194600.0 5541100.0 True False 3655067.865775788 4470220.439618914 4089719.680563203 1.0 1.2230198189959218 1.1189175771145798 21.801466763110422 -10.120153925301837 4.1181462765133094 0.9999637993003855 1.1709686979788658 0.7824320717533447 0.04249956249048855 14821199.935610302 0.46831863839010923 5719.688814660281 0.014548730630970653 7.583087629734075e-11 10.120153925301837 0.17100489867848034 K(ub)SDVEAIFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSDVEAIFSK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 25189800.0 8640600.0 5350200.0 11199000.0 True False 13108421.912474522 4395415.008696607 8985512.741303934 1.0 0.3353122929705022 0.6854763144870203 23.643990678063773 -10.649246992376563 6.760588108491317 1.0020823314074867 0.510394303729053 0.7227371136757308 0.14295386316606987 0.004501096685602171 0.00023352589577146628 0.13885701103884024 0.046138160943183536 2.242606143906937e-11 10.649246992376563 -0.49168802767843367 K(ub)SDVEAIFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSDVEAIFSK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 13498600.0 2442900.0 5326700.0 5729000.0 True False 3346106.146890212 5091348.78095866 4375928.192458668 1.0 1.521574199219721 1.3077672973780425 21.674051781336164 -10.130452088129092 4.598106900615066 0.9999591912017973 1.4146707483053989 0.8337589049275704 0.0872863021946129 60942000.54453861 1.9000167603679632 26862.1787905546 0.029880422916493805 7.405389600615055e-11 10.130452088129092 0.4147115571036015 K(ub)SDVEAIFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSDVEAIFSK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 9703700.0 3774900.0 3664800.0 2264000.0 True False 3138996.6064248118 3645056.994994152 2737391.932446734 1.0 1.1612172461523371 0.8720595386576449 21.5818720385447 -6.7553640885076165 1.629651943368643 1.0941807883440442 0.8712288772725977 0.6718595104353826 0.06777126110665264 0.2907795213843445 1.520825846383186 0.0328278406292646 0.0792642414652906 1.7564504854716356e-07 6.7553640885076165 -0.22295191107144652 K(ub)SDVEAIFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSDVEAIFSK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 22872600.0 8640600.0 5465100.0 8766900.0 True False 11185427.031689532 5160962.380791005 7171414.1559903575 1.0 0.4614005675571828 0.6411390584975397 23.415117000156222 -10.101629469794148 5.5493935771858025 1.0000046405946617 0.5512698130272491 0.8925943762038188 0.07337793165735347 4.212964562309776e-06 6.820413656741653e-07 0.07104861130502807 0.023682625607281856 7.91353504933276e-11 10.101629469794148 -0.44873482756741256 K(ub)SGALPVAWLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSGALPVAWLER 12 1 O43292;E9PLG8;E9PLV6;E9PPZ9;E9PM11 O43292 GPAA1 Glycosylphosphatidylinositol anchor attachment 1 protein 1 12258300.0 1502000.0 2252600.0 8503700.0 True False 1454319.8321532311 3152074.9271538192 6276325.864468297 1.0 2.1673877076178854 4.315643454559592 20.47191314911826 -6.961640354496238 0.4116705045165967 0.8960836970717933 5.666887771625971 0.9998262673938421 0.018099925880194403 0.07912037038622272 0.01900457999641328 0.0276767516546786 0.17926734998097835 1.0923445482253279e-07 6.961640354496238 4.770804074554178 K(ub)SGALPVAWLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSGALPVAWLER 12 1 O43292;E9PLG8;E9PLV6;E9PPZ9;E9PM11 O43292 GPAA1 Glycosylphosphatidylinositol anchor attachment 1 protein 1 8626000.0 1502000.0 2560100.0 4563900.0 True False 1248979.5498821335 2546308.233159935 5518190.388910623 1.0 2.038710908757658 4.418159119924242 20.252318424552538 -6.957306137008166 0.47186838994483427 0.9382798790265273 5.61644354694882 0.9996568746618283 0.026503489332882588 0.0806778193517357 0.024796065943348464 0.033016354772628626 0.19636396044625715 1.1033006219339208e-07 6.957306137008166 4.678163667922292 K(ub)SGNYFFLDD ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSGNYFFLDD 10 1 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 4550500.0 1785100.0 1468200.0 1297200.0 True False 1484389.7433386156 1460290.515185117 1568438.522424867 1.0 0.9837648917599661 1.0566217729969036 20.50143850694245 -6.848245241987358 1.2436757029923882 0.9913479917632979 1.0594347308222363 0.9376856780239874 0.007795853267998658 0.15940571236669057 0.4753676737331233 0.004907344552015861 0.011342900129108099 1.4182564195335187e-07 6.848245241987358 0.06808673905893836 K(ub)SGVGNIFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSGVGNIFIK 10 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;Q4VXU2;E5RH24;Q4VXU2-2;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC1L;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 5 1 34579200.0 12157000.0 15671000.0 6751200.0 True False 15937944.728555486 13332947.885079576 6052650.586083263 1.0 0.8365537785553602 0.3797635572947452 23.925962263358237 -6.953032415691959 0.5245000326923791 1.0075008132539367 0.18827427750410067 0.9994182579142445 0.006330856828380083 0.08229049520775751 0.03109654292982791 0.007121744926462128 0.03774899471630351 1.1142113658751881e-07 6.953032415691959 -0.8192265357498361 down K(ub)SGVGNIFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSGVGNIFIK 10 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;Q4VXU2;E5RH24;Q4VXU2-2;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC1L;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 5 1 24940220.0 580200.0 17505520.0 6854500.0 True False 561781.8685854234 24495565.42608084 5059100.819407785 1.0 43.60333929566133 9.005454078015529 19.099650536914627 -9.682227234881424 7.170932186810314 1.0002411109983043 26.304396686839404 0.4163083291482118 14.124527494463814 2.020577432531368e-06 0.0 13.676012698329728 4.558671646487606 2.0786088169188936e-10 9.682227234881424 25.3041555758411 K(ub)SGVGNIFIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSGVGNIFIK 10 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;Q4VXU2;E5RH24;Q4VXU2-2;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC1L;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 5 1 67237100.0 26884100.0 25461000.0 14892000.0 True False 40785145.190977015 20917285.622299034 11948589.672604542 1.0 0.5128652975085304 0.2929642549181841 25.281540452152413 -11.241005541181728 0.14781728106922973 2.0847884116855733 1.536146749613936e-09 0.9996532166060917 0.005501692227024894 3.6794733249886273 0.0895983679850466 1.531912501841787 0.21042223120519474 5.741091370777488e-12 11.241005541181728 -2.0847884101494265 K(ub)SGVGNIFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSGVGNIFIK 10 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;Q4VXU2;E5RH24;Q4VXU2-2;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC1L;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 5 1 31109900.0 12157000.0 9782500.0 9170400.0 True False 16651771.430572007 9350276.80359848 7004540.390316454 1.0 0.5615184452046786 0.42064836281960905 23.989172324881128 -13.999999999999998 0.15884635877935466 3.1542783954555302 0.2803881511739955 0.9995394498316444 0.005294337598863344 12.002200129842134 0.1259094980206863 7.967009649407556 0.12765217056574485 1.0000000000000041e-14 13.999999999999998 -2.873890244281535 K(ub)SGVGNIFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSGVGNIFIK 10 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;Q4VXU2;E5RH24;Q4VXU2-2;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC1L;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 5 1 23321330.0 580200.0 19436730.0 3304400.0 True False 482462.00721811916 19332020.477601185 3995334.762180643 1.0 40.06951881883884 8.28113862315871 18.880055812348903 -9.590310104882903 7.992570873316428 0.9999999922819889 24.175328720999286 0.4147549032821446 12.977551871503573 0.0 0.0 12.565460568218233 4.1884868560727435 2.568561065071267e-10 9.590310104882903 23.175328728717297 K(ub)SGVGNIFIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSGVGNIFIK 10 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;Q4VXU2;E5RH24;Q4VXU2-2;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC1L;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 5 1 65504100.0 26884100.0 25899000.0 12721000.0 True False 34801997.41483743 24457697.882949315 10405908.52848251 1.0 0.7027670737232473 0.299003198133854 25.052666774244862 -7.10482384602055 0.3497006081293926 1.0431612590184594 1.3127282439925778e-14 0.999904884912936 0.0028017505790905767 0.07679509389838675 0.015986874428935774 0.0066587385558620335 0.035208103529580245 7.85554198266389e-08 7.10482384602055 -1.0431612590184463 down K(ub)SGVGNVFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSGVGNVFIK 10 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 19385600.0 7568900.0 5779100.0 6037600.0 True False 7328629.4125064025 8086724.767608378 4456171.435882476 1.0 1.1034429921928206 0.6080497709814554 22.805111982598962 -6.852205518894944 1.2244072200776535 1.0553221160603856 0.5873875937705639 0.9434549925294808 0.05073760844392671 0.15504527194246234 0.4461850815271031 0.032406459350291926 0.07510356029475874 1.4053823050619766e-07 6.852205518894944 -0.4679345222898217 K(ub)SGVGNVFIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSGVGNVFIK 10 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 46042000.0 11274000.0 17141000.0 17627000.0 True False 17103482.239802517 14082054.626755718 14143015.723811433 1.0 0.8233443008456222 0.826908551458509 24.027786749477094 -9.839343180476389 5.839889486264375 1.0000000291485278 0.8251264261517175 0.9996885266430371 0.0014550992207902798 5.526270724605042e-10 1.1144371158692481e-10 0.0014088939926684045 0.0004696312539109711 1.447627482969249e-10 9.839343180476389 -0.17487360299681032 K(ub)SGVGNVFIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSGVGNVFIK 10 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 42387000.0 11274000.0 15427000.0 15686000.0 True False 14594415.24376405 14568473.88857711 12831308.951951638 1.0 0.998222514930975 0.8791930843158818 23.798913071569544 -6.91014731452142 0.894707267790314 1.003668260207331 0.8637607255781689 0.990977567211547 0.005370022487879412 0.10432136080133982 0.13823063972632682 0.004399710394358656 0.012157998254411976 1.229851529221409e-07 6.91014731452142 -0.13990753462916217 K(ub)SLANAESQQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSLANAESQQQR 12 1 Q9HCN4-2;Q9HCN4-4;Q9HCN4;Q9HCN4-5;Q9HCN4-3 Q9HCN4-2 GPN1 GPN-loop GTPase 1 1 4303060.0 815560.0 1181700.0 2305800.0 True False 789670.494214974 1653558.972484093 1701841.8074827446 1.0 2.0939860164433854 2.1551290316027027 19.590891259969148 -10.882322768285773 0.5193966305270885 2.1156236044452253e-18 2.151473046342784 0.9997902671557656 0.007685806223078816 2.5783312279574533 0.25190621122011453 3.1616841357507046 0.012000129210687802 1.3112250324663247e-11 10.882322768285773 2.151473046342784 K(ub)SLANAESQQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSLANAESQQQR 12 1 Q9HCN4-2;Q9HCN4-4;Q9HCN4;Q9HCN4-5;Q9HCN4-3 Q9HCN4-2 GPN1 GPN-loop GTPase 1 1 2218850.0 348800.0 1014800.0 855250.0 True False 477760.78596557654 969962.7805051625 653257.5644266496 1.0 2.030226860383326 1.3673319025260435 18.865928918405416 -10.194015442713127 4.928161314913795 0.9999254731380313 1.6987793814559482 0.5970333403626741 0.27062573330674383 0.0002216260070342771 3.624594289354529e-05 0.2620599914452605 0.08734407984538849 6.397120880927744e-11 10.194015442713127 0.6988539083179169 K(ub)SLEGADLPNLLFYGPPGTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSLEGADLPNLLFYGPPGTGK 21 1 P35249;C9JZI1;P35249-2;C9J8M3;C9JTT7;C9JXZ7;C9JGY5;F8WE44 P35249 RFC4 Replication factor C subunit 4 1 14570600.0 4577900.0 5441500.0 4551200.0 True False 4432577.070315764 7614319.32704762 3359104.1869266443 1.0 1.7178086711767422 0.7578219472870555 22.079714285162343 -6.706573941664764 1.8075770965047684 1.442831611067038 0.7603115811068638 0.4487625119554578 0.30264782160367315 0.3819940947890692 2.4308003598818932 0.13335581608600264 0.3401811688252169 1.9652873482154465e-07 6.706573941664764 -0.6825200299601742 K(ub)SLESINSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSLESINSR 9 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 41586600.0 14081500.0 21514400.0 5990700.0 True False 18460982.865439992 18304535.38247437 5370839.830852142 1.0 0.9915255063012652 0.29092924629200856 24.1379760285359 -6.909539494651709 0.8988524450234485 1.0220095539140943 0.2012714206060936 0.9907467891231638 0.03196318509738989 0.10472405141436616 0.14042062077780346 0.02610915829842294 0.0718463604940572 1.2315739815566307e-07 6.909539494651709 -0.8207381333080007 down K(ub)SLESINSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSLESINSR 9 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 53299400.0 19114800.0 25379900.0 8804700.0 True False 18508011.136912547 35514226.42443001 6498484.934661859 1.0 1.9188569836982707 0.3511174100009709 24.141646536347313 -6.747881973106434 1.6578532442913232 1.541687592697631 0.3485393765477606 0.6396883186145552 0.3860765510075498 0.30377991290402634 1.6420890644192412 0.1840212220343729 0.44772208310786094 1.7869731491380607e-07 6.747881973106434 -1.1931482161498703 K(ub)SLESINSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSLESINSR 9 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 27793400.0 14081500.0 11906600.0 1805300.0 True False 19287811.088228974 11380527.042139094 1378925.3213205854 1.0 0.5900372515098117 0.0714920586381168 24.20118609005879 -7.66121905946039 0.535210884058108 1.0118698224394793 5.666125157442298e-20 0.9945203379247612 0.028123832575517867 0.1170485502567755 0.09987978027990352 0.030377447153142174 0.07510002446183213 2.1816292138436132e-08 7.66121905946039 -1.0118698224394793 down K(ub)SLESINSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSLESINSR 9 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 64689200.0 19114800.0 42629000.0 2945400.0 True False 15894803.12921908 42399349.11580601 3561269.5220091 1.0 2.667497594724164 0.22405244613961237 23.92205181178159 -6.722971026250244 1.7485357460936397 2.0112424071456014 0.22718488154597014 0.5265485662349765 0.7014447784372823 0.3495725860046413 2.090264524221307 0.31832787655167144 0.7963699992191081 1.892469869660602e-07 6.722971026250244 -1.7840575255996314 K(ub)SLESINSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSLESINSR 9 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 41192600.0 19930600.0 19551000.0 1711000.0 True False 25800554.590860765 18462969.663289763 1399615.5563425494 1.0 0.715603596747096 0.05424749888276936 24.620898741367245 -7.354206664805583 0.6751445381618101 0.9957064890909922 3.28704675090644e-17 0.9933456185436732 0.0323192135819114 0.10590582077080957 0.09806924130485416 0.0291081511453216 0.06688914512796493 4.423778109021645e-08 7.354206664805583 -0.9957064890909922 down K(ub)SLNQSLAEWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSLNQSLAEWK 11 1 P54709;H7C547;F8WBY4 P54709 ATP1B3 Sodium/potassium-transporting ATPase subunit beta-3 1 10730900.0 3450900.0 4204200.0 3075800.0 True False 4524163.318563138 3576949.7478432483 2757545.7211569636 1.0 0.7906323215978148 0.609515069856663 22.109219579692635 -6.972818307120008 0.1784539563236942 1.142914992658337 0.25234214838732766 0.9999968403335083 0.0002835553177071529 0.07539831397330968 0.0056180969219073625 0.007070936797376919 0.020421797057727505 1.0645883097674828e-07 6.972818307120008 -0.8905728442710095 K(ub)SLNQSLAEWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSLNQSLAEWK 11 1 P54709;H7C547;F8WBY4 P54709 ATP1B3 Sodium/potassium-transporting ATPase subunit beta-3 1 5431900.0 2057000.0 3374900.0 0.0 True False 1710486.640550966 3356718.743834803 0.0 1.0 1.9624349376698833 0.0 20.7059754055632 -6.779973426299049 1.5795166520018957 1.5493028351900235 2.5329807922061015e-19 0.7429319737926687 0.4062283174757455 0.256417615634581 1.2705303527317502 0.20399391286649765 0.4728305693037248 1.6596884576927142e-07 6.779973426299049 -1.5493028351900235 K(ub)SLSDSESDDSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSLSDSESDDSK 12 1 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 4812200.0 1527700.0 2167800.0 1116700.0 True False 2002829.494267844 1844372.6900182166 1001154.5961427864 1.0 0.9208835276776505 0.4998701082683873 20.933608175574797 -6.938425274945403 0.6740529936519741 1.0048791495005625 0.391408925188161 0.9979503010601991 0.009937775728249991 0.0884924056568651 0.057936323100925204 0.009561947796980177 0.03649434180228034 1.1523243126089382e-07 6.938425274945403 -0.6134702243124015 down K(ub)SLSDSESDDSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSLSDSESDDSK 12 1 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 5050900.0 1681700.0 2333000.0 1036200.0 True False 1628315.354016038 3264579.066434275 764788.1346663286 1.0 2.0048813384843394 0.46968060135284817 20.63494870112517 -6.730090990321299 1.722811400893819 1.6046627864519414 0.47056201382166457 0.5597477715186403 0.42242439737341353 0.3360567833404342 1.954110077221002 0.19430072387094208 0.4821103899681912 1.8616970461458076e-07 6.730090990321299 -1.1341007726302768 K(ub)SLSDSESDDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSLSDSESDDSK 12 1 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 4583120.0 1527700.0 2161200.0 894220.0 True False 2092531.9745401673 2065711.0378673202 683023.6530389929 1.0 0.9871825439232579 0.32641013917557316 20.99681823709769 -6.91109920378318 0.8882233472677142 1.019754756122528 0.23898001834623273 0.9913295434042728 0.029289946269508926 0.10369574048965222 0.13486078570494792 0.02411110494354749 0.06707488215843978 1.2271588851853233e-07 6.91109920378318 -0.7807747377762952 down K(ub)SLSDSESDDSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSLSDSESDDSK 12 1 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 4429020.0 1681700.0 2160000.0 587320.0 True False 1398408.0619419334 2148363.651273567 710125.8965391415 1.0 1.5362923811310054 0.5078102135316697 20.415353976559448 -6.7650061690337475 1.5935063597194883 1.3095684253677484 0.5030811914665597 0.7110751417251676 0.22575982060457758 0.2746062099791259 1.375297893377329 0.11172316271312276 0.26719120155144466 1.717883984914438e-07 6.7650061690337475 -0.8064872339011887 K(ub)SMVPVQVQLDVPVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSMVPVQVQLDVPVVK 16 1 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 1 8242300.0 2247400.0 2273000.0 3721900.0 True False 2176057.517164563 3180620.7535384116 2747022.735393366 1.0 1.4616436966623982 1.2623851684641036 21.05328525947466 -10.156086452842455 4.543270679682864 0.9999499534618513 1.3620144325674584 0.8148509428965234 0.08134695353930578 9494458.103329696 21224039.348534316 3080.604089335147 0.027847223478262247 6.980934242587706e-11 10.156086452842455 0.362064479105607 K(ub)SMVPVQVQLDVPVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSMVPVQVQLDVPVVK 16 1 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 1 5587000.0 1182000.0 2093900.0 2311100.0 True False 1619017.3423489432 2001384.5743986566 1765265.7785985754 1.0 1.2361724127642497 1.0903316057365071 20.626687008693384 -10.290693119940123 4.234660767296556 0.9998381232344781 1.1632520092543452 0.6255659059847755 0.05953926016224767 9.10830212732661e-05 1.5256435744499247e-05 0.0577056585779523 0.019216213585980378 5.1204352662833564e-11 10.290693119940123 0.16341388601986717 K(ub)SMVPVQVQLDVPVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSMVPVQVQLDVPVVK 16 1 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 1 6993300.0 2247400.0 2515000.0 2230900.0 True False 1868812.6767011376 2501451.195811587 2697370.8754838454 1.0 1.3385243085075784 1.4433607547254517 20.833690534908936 -12.498590962908 0.1852503975061975 1.2262458342488636e-07 1.5283327784297809 0.9994548059916029 0.0044176211738499345 6.648323069050439 0.12440526792810906 2.548269684580159 0.07453841346698892 3.1725541033059594e-13 12.498590962908 1.5283326558051975 K(ub)SMYEEEINETR ddPTM_RPMI8226_Bortezomib_1h_R1 2 KSMYEEEINETR 12 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 17717610.0 7553400.0 6902300.0 3261910.0 True False 9902580.547229657 5872503.744954665 2924398.8436501403 1.0 0.5930276170889168 0.2953168449074892 23.239373100330734 -7.996152276085989 0.2356593206041636 1.1952755787919125 9.969542911901016e-09 0.9996947817911745 0.00504610624523995 0.10219487279187571 0.04231463203031245 0.07013977978369763 0.0975956586047467 1.0088990751359036e-08 7.996152276085989 -1.1952755688223695 down K(ub)SMYEEEINETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSMYEEEINETR 12 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 16067270.0 6095270.0 4992900.0 4979100.0 True False 5901778.990232108 6986591.007629524 3674924.340201807 1.0 1.183811020235231 0.6226807791826983 22.492718465074407 -6.818482900411078 1.3786169672766004 1.0992251248114062 0.6108428629189911 0.8808202444065218 0.08063639409182663 0.19545817044109698 0.7303849533959855 0.0459706100436658 0.1059902571316763 1.5188577432331442e-07 6.818482900411078 -0.48838226189241507 K(ub)SNQIPTEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSNQIPTEVR 10 1 Q9BWH2 Q9BWH2 FUNDC2 FUN14 domain-containing protein 2 1 42384000.0 13059500.0 18144200.0 11180300.0 True False 17121130.968377918 15437156.085537655 10023469.805010468 1.0 0.9016434786959752 0.5854443741785188 24.029274669021767 -6.94988619222632 0.5600904899212451 1.0041334973253857 0.4678403161365351 0.9991923294124241 0.005026251765400754 0.08353145069312252 0.03615156922725409 0.005387266229893328 0.02628523618261711 1.1223125201038315e-07 6.94988619222632 -0.5362931811888506 K(ub)SNQIPTEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSNQIPTEVR 10 1 Q9BWH2 Q9BWH2 FUNDC2 FUN14 domain-containing protein 2 1 27963600.0 10141700.0 12693800.0 5128100.0 True False 9819757.284785908 17762500.537292488 3784896.7702976237 1.0 1.8088533170583094 0.3854368963030987 23.227255935171353 -6.75251336619393 1.6401966476535506 1.4741516441384155 0.3819901174989964 0.6599070503994391 0.33993787295718486 0.2956539443500978 1.565590924446778 0.16365958000759553 0.39633254440099774 1.7680178029686066e-07 6.75251336619393 -1.0921615266394191 K(ub)SNQIPTEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSNQIPTEVR 10 1 Q9BWH2 Q9BWH2 FUNDC2 FUN14 domain-containing protein 2 1 88301000.0 10167000.0 40650000.0 37484000.0 True False 15424082.30726204 33395689.90010035 30075270.9701792 1.0 2.16516543641477 1.9498904616204633 23.878681319541034 -10.240010182731355 5.813633031870241 0.99995963759703 2.0575279490176244 0.9698579503006312 0.08788564043946792 4.598055784518412e-05 6.010702780485705e-06 0.08509812769110303 0.028364968482730013 5.754264453821716e-11 10.240010182731355 1.0575683114205945 K(ub)SNQIPTEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSNQIPTEVR 10 1 Q9BWH2 Q9BWH2 FUNDC2 FUN14 domain-containing protein 2 1 37814100.0 13059500.0 10263600.0 14491000.0 True False 17887950.069717456 9810120.214813532 11068524.251513088 1.0 0.5484205946784871 0.618769853916968 24.09248473054466 -10.660953457073068 6.655035456756907 1.0023075384004012 0.5835952242977536 0.9790419800613461 0.028719964819508947 0.000987510553387546 5.03095038742749e-05 0.027927124432366644 0.009269328787468415 2.1829638454684844e-11 10.660953457073068 -0.41871231410264764 K(ub)SNQIPTEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSNQIPTEVR 10 1 Q9BWH2 Q9BWH2 FUNDC2 FUN14 domain-containing protein 2 1 47118500.0 10141700.0 24897600.0 12079200.0 True False 8433272.903488442 24763471.68701331 14604904.872089475 1.0 2.93640108299707 1.7318193113433011 23.00766121060563 -10.127604136300928 4.724056046874558 0.9999383787393176 2.33411019714249 0.6205648262738452 0.4917684495731575 0.0005226875345486983 9.652436993216697e-05 0.476188178554335 0.15871758452993268 7.454111139119392e-11 10.127604136300928 1.3341718184031723 K(ub)SNQIPTEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSNQIPTEVR 10 1 Q9BWH2 Q9BWH2 FUNDC2 FUN14 domain-containing protein 2 1 66410470.0 10167000.0 38946000.0 17297470.0 True False 13161381.92153177 36778620.86371458 14149507.947030134 1.0 2.7944345877195054 1.0750776803978166 23.649807641633483 -6.636156415471936 2.0580418037211117 2.1768466547759977 1.0821283182531958 0.14011488237215042 0.7685234974420115 0.5431545092504751 4.391852336326563 0.3045787030253581 0.8511970791058335 2.311232227010325e-07 6.636156415471936 -1.094718336522802 K(ub)SPNELVDDLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSPNELVDDLFK 12 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 3573710.0 1060100.0 1593600.0 920010.0 True False 1389801.366023002 1355841.0918041465 824816.1905590799 1.0 0.9755646561810234 0.5934777520900988 20.4064472733297 -6.919927764883829 0.8252817599921639 1.0084526746254991 0.5319690545513137 0.994160364185039 0.014224694635774537 0.09821439423924312 0.10584125171105618 0.012251293693876585 0.0366720667269421 1.202464420888337e-07 6.919927764883829 -0.47648362007418543 K(ub)SPNELVDDLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSPNELVDDLFK 12 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 9545540.0 3101300.0 4157740.0 2286500.0 True False 3002850.9290657924 5817947.264327667 1687597.056470334 1.0 1.9374745539358726 0.5619982797465598 21.517901426092145 -6.723187245284621 1.7476640543979847 1.5683938985250774 0.563720600152549 0.5275886420138274 0.3943467630634231 0.34916424633700616 2.0858342273477484 0.1790390060745116 0.44780978923470144 1.8915279139553695e-07 6.723187245284621 -1.0046732983725284 K(ub)SPNELVDDLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSPNELVDDLFK 12 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 4037700.0 1060100.0 1728400.0 1249200.0 True False 1452047.618125306 1652033.572945527 954164.6880815794 1.0 1.137726857111213 0.6571166648883541 20.46965733485259 -6.830087412922765 1.3274409430964251 1.0735889942744052 0.6441536185281561 0.9060624607899052 0.06193570456535944 0.18070441410223267 0.6227025079130482 0.03663288535507247 0.08430586535043207 1.4788107095612525e-07 6.830087412922765 -0.4294353757462491 K(ub)SQETAFE ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSQETAFE 8 1 P62253;I3L2H7 P62253 UBE2G1 Ubiquitin-conjugating enzyme E2 G1;Ubiquitin-conjugating enzyme E2 G1, N-terminally processed 1 4560980.0 1347400.0 2736000.0 477580.0 True False 1120422.7999408701 2721260.624946523 577439.7699195718 1.0 2.4287801221914944 0.5153766684773337 20.095611816138184 -6.70677159418851 1.8062751320127948 1.8812402804631423 0.5202010039222296 0.4499467626620992 0.6023913404726129 0.38160775940506014 2.4248377117766875 0.26557476567149635 0.6774499365703821 1.9643931263426496e-07 6.70677159418851 -1.3610392765409127 K(ub)SSGGKGGSYSQAASSDSAQGSDVSLTA ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSSGGKGGSYSQAASSDSAQGSDVSLTA 28 2 D9J307 D9J307 HLA-B 1 11004700.0 1013700.0 2196200.0 7794800.0 True False 1312254.633014337 2073979.5393850442 6376226.381402044 1.0 1.5804703501948962 4.8589856122324555 20.32361626042593 -6.937127368002121 0.6857648603554719 0.9607366572150924 5.673076232714234 0.9977629525903439 0.08035520179732246 0.08910187812965356 0.06076232092522412 0.0766118300987875 0.28592894125075036 1.1557732323218611e-07 6.937127368002121 4.712339575499142 up K(ub)SSHAVELACR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSSHAVELACR 11 1 Q9UBB4;A0A1W2PQD2 Q9UBB4 ATXN10 Ataxin-10 1 8341700.0 1603400.0 4283900.0 2454400.0 True False 2432475.0242415653 3519404.574736529 1969286.7641982625 1.0 1.4468409910329352 0.8095814939815372 21.213993561344818 -6.7182413633694 1.7657144214372211 1.272365304810202 0.81067734098979 0.5041510151204569 0.18807439837417142 0.3587569519154995 2.184992575142214 0.0846068927427296 0.21282982852372154 1.9131923543016558e-07 6.7182413633694 -0.4616879638204119 K(ub)SSLLTELSNSLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSSLLTELSNSLTK 14 1 Q9UBK9-2;Q9UBK9 Q9UBK9-2 UXT Protein UXT 1 31820600.0 4312600.0 11614000.0 15894000.0 True False 6542529.493291861 9541390.959403837 12752543.933412336 1.0 1.4583642258222522 1.9491763768872088 22.641417092186327 -6.970255146440202 0.2520184827533566 0.8480562691168225 2.573896594660369 0.9999843044754193 0.0015354678086350073 0.07622000860898093 0.008733466702085546 0.010798905459783372 0.04688612301041471 1.0708899763965551e-07 6.970255146440202 1.7258403255435464 K(ub)SSLLTELSNSLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSSLLTELSNSLTK 14 1 Q9UBK9-2;Q9UBK9 Q9UBK9-2 UXT Protein UXT 1 28626100.0 4312600.0 7174500.0 17139000.0 True False 5582745.714055078 6775232.76810763 14019877.860990636 1.0 1.213602251496133 2.5112872015098766 22.412543414278776 -6.935572287165658 0.6995478618305631 0.9837381310438807 2.8199026951637305 0.9975244510884188 0.033226270857628096 0.08984593047068294 0.06425216939152911 0.03134607599042062 0.11403636687970434 1.1599191346133055e-07 6.935572287165658 1.8361645641198496 up K(ub)SVAKLQDER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSVAKLQDER 10 2 O14818;Q8TAA3-5;Q8TAA3;O14818-4;A0A087WYS6 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 1 2141650.0 428910.0 910440.0 802300.0 True False 562305.1635703478 774605.9008673249 719285.6922050312 1.0 1.3775543086764077 1.2791731942099516 19.100993769444873 -10.100562207214129 4.388036906748225 0.999963481332287 1.32836375146296 0.9369220197550983 0.04016392187763235 27959116.776514288 0.5980186298175632 10485.73135136394 0.013749178744125451 7.933006183175772e-11 10.100562207214129 0.3284002701306731 K(ub)SVAKLQDER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSVAKLQDER 10 2 O14818;Q8TAA3-5;Q8TAA3;O14818-4;A0A087WYS6 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 1 1847970.0 428910.0 697050.0 722010.0 True False 587489.6178569238 666252.0261638974 551486.1082627134 1.0 1.1340660428932978 0.9387163474896016 19.164203830967764 -6.722005826914443 1.7517750587519305 1.081392415463911 0.9389811128344424 0.5219388873174886 0.056402823993141886 0.35152294113705684 2.1091705674233605 0.025552600279839445 0.06400357166428398 1.896680473342372e-07 6.722005826914443 -0.14241130262946855 K(ub)SWPEPDQKPEPVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSWPEPDQKPEPVDK 15 2 Q96S82;H3BV23 Q96S82 UBL7 Ubiquitin-like protein 7 1 20653800.0 2941600.0 8678400.0 9033800.0 True False 4462622.259766114 7129671.715351318 7248265.470344794 1.0 1.5976417676285655 1.6242166709231347 22.08946026365182 -11.40199811283305 0.5118560002377995 1.8045838417905856e-18 1.6227070112216826 0.9998666261124234 0.003328337314436618 3.9183377963826054 0.25155354150014075 4.393915931365312 0.005291132806767241 3.96279756230885e-12 11.40199811283305 1.6227070112216826 K(ub)SWPEPDQKPEPVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSWPEPDQKPEPVDK 15 2 Q96S82;H3BV23 Q96S82 UBL7 Ubiquitin-like protein 7 1 21975400.0 2941600.0 9097900.0 9935900.0 True False 3807959.1876047906 8591593.867303144 8127668.150943268 1.0 2.256220049644824 2.1343895116837053 21.86058658574427 -10.371527357426958 6.4200637654668045 0.999889682549546 2.195304780664265 0.9922688228250388 0.04973710884891991 7.854248762621331e-05 7.688652312613894e-06 0.04816206382013243 0.016052582855030945 4.250819288588015e-11 10.371527357426958 1.195415098114719 K(ub)SYAGYQTL ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSYAGYQTL 9 1 H0YCG2;P13473-2 H0YCG2 LAMP2 Lysosome-associated membrane glycoprotein 2 1 8824200.0 4426000.0 2043500.0 2354700.0 True False 4285499.05266991 2859480.206711724 1737933.4305141899 1.0 0.6672455580010543 0.4055381670033131 22.031031787405002 -7.554929691966114 0.19164708093117838 1.2183929854384565 1.4359745827319518e-15 0.9999508226521346 0.001705924706769633 0.13187862814163714 0.019353658099963353 0.03744145551806996 0.070975715642258 2.7865722509405628e-08 7.554929691966114 -1.2183929854384552 down K(ub)SYAGYQTL ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSYAGYQTL 9 1 H0YCG2;P13473-2 H0YCG2 LAMP2 Lysosome-associated membrane glycoprotein 2 1 9357900.0 4426000.0 2934600.0 1997300.0 True False 3680415.10504549 2918790.727327508 2414926.19552821 1.0 0.7930601967495815 0.656155929861711 21.81143706283928 -8.485780091422523 0.07316423442512676 1.6546359881778039 7.52441486458821e-11 0.9999940064373437 0.00034597948331480826 0.14305938060272175 0.017465805765261414 0.19909591556464912 0.1855838165000833 3.2675324447860566e-09 8.485780091422523 -1.6546359881025596 K(ub)SYEPLEDPGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSYEPLEDPGVK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 8883300.0 4897200.0 2367900.0 1618200.0 True False 6420276.6245522555 2014618.550001907 1450764.1868704732 1.0 0.31378999189811463 0.22596599363374756 22.614204028084853 -13.999999999999998 0.28985072009106966 6.9080827770645685 0.20199764525127115 0.9996271282835664 0.0066820921223627655 15.956828716460704 0.17072651644100476 56.209134319777 0.033191240386181146 1.0000000000000041e-14 13.999999999999998 -6.706085131813297 K(ub)SYEPLEDPGVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSYEPLEDPGVK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 9177400.0 2940600.0 4339500.0 1897300.0 True False 2847252.262603057 6072284.98019354 1400340.2122200588 1.0 2.1326824672156186 0.4918216171474104 21.44113888884754 -6.720957195658071 1.7555974015259699 1.688389228472402 0.494191730788039 0.517161094002082 0.4765810768024338 0.3534578875362035 2.129500035763559 0.21549043844403964 0.5404094423299974 1.9012656606486057e-07 6.720957195658071 -1.194197497684363 K(ub)SYEPLEDPGVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSYEPLEDPGVK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 32030800.0 14536300.0 4728100.0 12766400.0 True False 22052629.845879152 3884333.6141860937 10243115.444288108 1.0 0.1761392469439166 0.46448498505053265 24.39444737620168 -10.397506910702042 5.897100235845629 1.0001902599548047 0.32031211603975906 0.8810728286457548 0.11771665464456878 0.0002945399638134865 3.0092346383722895e-05 0.1140097973996886 0.03799288691747178 4.00399096937431e-11 10.397506910702042 -0.6798781439150456 K(ub)SYEPLEDPGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSYEPLEDPGVK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 9970800.0 4897200.0 2815200.0 2258400.0 True False 6707827.1818538355 2690815.1553785303 1725012.433208004 1.0 0.40114556956055514 0.2571641138690255 22.677414089607744 -13.999999999999998 0.20021151937077789 4.331629359891926 0.16385062727467453 0.9994869397997173 0.007285770677044898 12.53508032804661 0.14187825390343353 16.35552741585901 0.09153543495765999 1.0000000000000041e-14 13.999999999999998 -4.1677787326172515 K(ub)SYEPLEDPGVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSYEPLEDPGVK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 9922600.0 2940600.0 5880100.0 1101900.0 True False 2445239.1906680437 5848422.734191531 1332302.1953900412 1.0 2.3917589561427453 0.5448555709701569 21.221544164281816 -6.705149354787053 1.8128323344042498 1.8598594353189903 0.5498514532692217 0.4418618843745583 0.5869478236377544 0.3849234315746054 2.46281128515347 0.25797735038533987 0.6591849300432238 1.9717445324060446e-07 6.705149354787053 -1.3100079820497688 K(ub)SYEPLEDPGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSYEPLEDPGVK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 34516600.0 14536300.0 5622700.0 14357600.0 True False 18817526.903310943 5309791.802249465 11744664.121416599 1.0 0.2821726696357324 0.6241343074338916 24.16557369829413 -10.6021458303619 6.560518777016512 1.0013419480250372 0.45315348853624643 0.7732266712310167 0.13960525403532123 0.0027457624036525147 0.00016651320292802667 0.1354480927465631 0.04505740199348792 2.49950591962966e-11 10.6021458303619 -0.5481884594887907 K(ub)TAEDMNLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTAEDMNLFK 10 1 O95864;O95864-4;O95864-2;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 58820400.0 2754400.0 22852000.0 33214000.0 True False 4178626.1736129257 18773882.056509063 26649238.341786634 1.0 4.492835988790254 6.377511946407294 21.99459726801844 -8.59466395733652 0.3209730036476373 9.54247007663991e-23 7.202820690222559 0.9983952323945227 0.08924637108130369 0.22054025063814667 0.09587590621985709 0.8117132865427515 0.5751639964881464 2.5429395867941382e-09 8.59466395733652 7.202820690222559 K(ub)TAEDMNLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTAEDMNLFK 10 1 O95864;O95864-4;O95864-2;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 58153400.0 2754400.0 14415000.0 40984000.0 True False 3565625.097341118 13612792.578196596 33525332.53135184 1.0 3.8177857196337435 9.40237170653517 21.765723590110888 -6.960222264398006 0.4322908626171917 0.7834869889160944 12.651641783262436 0.9997783518841216 0.05198382646209755 0.0796218270277111 0.020838731498436364 0.07298737356612424 0.46345213083649683 1.095917181154054e-07 6.960222264398006 11.868154794346342 K(ub)TASPEDSDMPDHDLEPPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTASPEDSDMPDHDLEPPR 19 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 10162100.0 2370600.0 3010600.0 4780900.0 True False 3107879.5569230565 2561430.2152268854 4286218.329631101 1.0 0.8241729347332941 1.3791455721259207 21.567499163804424 -6.821503563536043 1.3652293256811794 0.9053662395066634 1.3916673398753578 0.8878116910523541 0.07756641451513559 0.1915509731299937 0.7010965026211955 0.04464050905697463 0.10285668467022598 1.508330234119804e-07 6.821503563536043 0.48630110036869445 K(ub)TASPEDSDMPDHDLEPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTASPEDSDMPDHDLEPPR 19 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 14276900.0 3056300.0 2508500.0 8712100.0 True False 2959279.4294340345 3510157.1316546854 6430139.652602309 1.0 1.186152648087716 2.1728734328518886 21.49681449851074 -6.938512456814415 0.6732681354860184 0.9885877434543745 2.427700168282251 0.9979623965435448 0.02323179883947912 0.08845199674518375 0.05775123685703625 0.02236714837956539 0.08549674775688962 1.1520930140117705e-07 6.938512456814415 1.4391124248278766 up K(ub)TASPEDSDMPDHDLEPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTASPEDSDMPDHDLEPPR 19 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 8009420.0 2370600.0 524120.0 5114700.0 True False 3247074.883056178 500962.6453669342 3906713.2005530414 1.0 0.1542812110620077 1.2031484770920975 21.630709225327315 -6.692109534393389 1.8586666425318759 0.47083738889359017 1.1996400020263205 0.38036128449937723 0.35752873063493984 0.41218974664442587 2.7623721940557684 0.15378095465922506 0.39943211984343746 2.0318444902132666e-07 6.692109534393389 0.7288026131327303 K(ub)TCAYTNHTVLPEALER ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTCAYTNHTVLPEALER 17 1 P11216 P11216 PYGB Glycogen phosphorylase, brain form 1 16616400.0 10385800.0 6230600.0 0.0 True False 15756017.90368469 5118700.750100007 0.0 1.0 0.3248727426809379 0.0 23.909399625622566 -8.62094850195491 0.5013014847663456 1.0629664033895019 7.908400574634935e-21 0.9942475486395916 0.031590306184642765 0.2785515644920573 0.18801993255617258 0.09574046994565812 0.06399381373043149 2.393599569337938e-09 8.62094850195491 -1.0629664033895019 K(ub)TCAYTNHTVLPEALER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTCAYTNHTVLPEALER 17 1 P11216 P11216 PYGB Glycogen phosphorylase, brain form 1 16548400.0 10385800.0 6162600.0 0.0 True False 13444622.834724577 5819645.89263922 0.0 1.0 0.43286047992423576 0.0 23.680525947715015 -8.154842866655608 0.5542721941482148 1.0235751105291295 3.5091050186729364e-16 0.9908486508933656 0.03917131421054158 0.1218457761259594 0.17123747973385192 0.05156598543980406 0.07383134409794122 7.0009525367505906e-09 8.154842866655608 -1.023575110529129 K(ub)TEPATGFIDGDLIESFLDISRPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTEPATGFIDGDLIESFLDISRPK 24 2 Q16531;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 130423000.0 34457000.0 56774000.0 39192000.0 True False 52273788.144125976 46642236.12271333 31445684.021536138 1.0 0.8922681477400166 0.6015573988025527 25.639584375617968 -6.953804770533433 0.5153851433762188 1.0051220813934731 0.4758318826108064 0.9994670264390393 0.0038850360877332487 0.08199297934097591 0.029910863666523773 0.004434302088731793 0.02400276461862853 1.1122315991250737e-07 6.953804770533433 -0.5292901987826668 K(ub)TEPATGFIDGDLIESFLDISRPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTEPATGFIDGDLIESFLDISRPK 24 2 Q16531;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 102185000.0 34457000.0 50703000.0 17025000.0 True False 44605265.74901355 47881333.47848091 13926624.691251855 1.0 1.0734457619398852 0.31221929647532354 25.410710697710417 -6.883218918809948 1.0616400644335533 1.0477938092886638 0.2548179053777067 0.9761922824652584 0.05290057658882348 0.1248189005446358 0.25535666493017894 0.03826523800415051 0.09334390673818974 1.30852215793913e-07 6.883218918809948 -0.7929759039109572 down K(ub)TFSYAGFEMQPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTFSYAGFEMQPK 13 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 12015100.0 2951300.0 4440500.0 4623300.0 True False 3869182.880429851 3777994.7089334317 4144925.2658251505 1.0 0.9764321888330364 1.0712663096877617 21.883597490003414 -6.840927218948944 1.2781268166605018 0.987463848740226 1.0744423082681136 0.9260306328287147 0.010964648868844223 0.16771787252006098 0.53182494110399 0.006725853421389128 0.015498726347028306 1.4423570480478954e-07 6.840927218948944 0.08697845952788763 K(ub)TFSYAGFEMQPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTFSYAGFEMQPK 13 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 37904500.0 6437400.0 9619100.0 21848000.0 True False 9766006.436979303 7902496.450628667 17529733.223681416 1.0 0.8091840305066363 1.794974571929884 23.21933729821037 -6.856516640507928 1.2031945675773776 0.897282837699416 1.839634474234393 0.9492645865467758 0.09615677227495982 0.15043499113162945 0.4158226436083397 0.06241363363483765 0.14516895707712926 1.3915004768328217e-07 6.856516640507928 0.9423516365349771 K(ub)TFSYAGFEMQPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTFSYAGFEMQPK 13 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 11451800.0 2951300.0 3258000.0 5242500.0 True False 4042475.36588361 3114050.7872347417 4004329.472676658 1.0 0.7703326564499838 0.9905637289644648 21.946807551526305 -10.63790163199407 8.447003529980773 1.0001044503628702 0.8804481927266783 0.2820788790848021 0.08990895886105989 0.00017700891187839916 7.587737457425756e-06 0.08712967633240426 0.02901799169531103 2.3019631546399477e-11 10.63790163199407 -0.11965625763619192 K(ub)TFSYAGFEMQPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTFSYAGFEMQPK 13 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 29688200.0 6437400.0 7968800.0 15282000.0 True False 8333341.20012477 7525329.274861813 12500832.806561578 1.0 0.9030386605014012 1.5000985206719257 22.99046362030282 -6.865266374078181 1.1589279367887755 0.9464617521960831 1.5320462534926351 0.9597214689519876 0.05250480374121468 0.14146965573735093 0.35812738111804787 0.03525355205457566 0.08283901826036402 1.3637464275353708e-07 6.865266374078181 0.585584501296552 K(ub)TGCNVLLIQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTGCNVLLIQK 11 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 1 15668600.0 8044200.0 3453500.0 4170900.0 True False 10413375.474887954 3261309.6891295183 3411838.9970480073 1.0 0.31318468223816825 0.3276400630396666 23.311934455378292 -9.956313831398745 5.8952631916116385 1.0000004780141767 0.32041237271849615 0.9996607791958808 0.005901384501029009 3.7080960854510673e-08 6.5571170728663704e-09 0.005713995059374158 0.0019046636575521213 1.1058244004866254e-10 9.956313831398745 -0.6795881052956805 K(ub)TGNQHFGYLYGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTGNQHFGYLYGR 13 1 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 5973900.0 1052000.0 3082600.0 1839300.0 True False 1379182.187582493 2622688.095880688 1648986.879811432 1.0 1.9016255571556366 1.1956265783144049 20.395381616285263 -10.249931971561674 4.8165327850348385 0.9998661713216286 1.5486260677359678 0.44603321153293496 0.28822287618442755 0.00041430368909981956 6.45181239996544e-05 0.2791380451728725 0.09302353328772699 5.624294179478702e-11 10.249931971561674 0.5487598964143392 K(ub)TGNQHFGYLYGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTGNQHFGYLYGR 13 1 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 12675600.0 2959800.0 2608500.0 7107300.0 True False 2865842.769112608 3650087.6531478004 5245684.915570349 1.0 1.2736524461451977 1.8304161596397162 21.450528029432277 -6.959708800892463 0.4395257685190543 0.9799937696324521 2.145764884713305 0.9997592266638685 0.005361401338911856 0.07980540822598073 0.021517586952883562 0.007336293285559945 0.04613547091021371 1.0972136430674216e-07 6.959708800892463 1.165771115080853 K(ub)TGNQHFGYLYGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTGNQHFGYLYGR 13 1 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 9950100.0 2959800.0 4375200.0 2615100.0 True False 2461204.841372265 4351629.929190797 3161905.3191437526 1.0 1.7680892935203678 1.2846981551445373 21.230933304866554 -10.428795344366357 4.997985615042744 0.9992647452629209 1.5263937243324859 0.6125701616185317 0.19734360586746963 0.0016189468812229054 0.0001850241256547182 0.19133015880213694 0.06369237491708014 3.7256723236317977e-11 10.428795344366357 0.527128979069565 K(ub)TGQAPGYSYTAANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTGQAPGYSYTAANK 15 1 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 1 5038300.0 1886500.0 1727900.0 1423900.0 True False 2473219.76889199 1470104.0553014483 1276568.4870132657 1.0 0.594408986129065 0.5161565110670178 21.23795901180307 -13.999999999999988 0.2313510640963998 3.5764890010770496 0.4785953050840342 0.9995116680982816 0.004686188548220639 13.333793133500546 0.1522869867862005 15.79285575259568 0.040281564428988975 1.0000000000000286e-14 13.999999999999988 -3.0978936959930152 K(ub)TGQAPGYSYTAANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTGQAPGYSYTAANK 15 1 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 1 6406600.0 1522100.0 1756000.0 3128500.0 True False 1473781.768655418 2457179.9574190294 2309051.997011783 1.0 1.66726174097051 1.5667529929606954 20.4910914814182 -10.084275727444421 4.35720600956756 0.9999377384804731 1.6170073670253042 0.9804867312988267 0.04103252476354639 5341295.104425024 3090461.976049655 2972.029417246698 0.014046525239489058 8.236150474031427e-11 10.084275727444421 0.6170696285448312 K(ub)TGQAPGYSYTAANK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTGQAPGYSYTAANK 15 1 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 1 12480000.0 2719600.0 1669500.0 8090900.0 True False 4125832.0293921363 1371564.681136964 6491730.068632549 1.0 0.33243347556711805 1.5734353755523545 21.976253656836555 -6.7605937462737415 1.610138789888487 0.6125194078766466 1.5781151307311503 0.6933892786091846 0.2808060969905932 0.28193912297872536 1.4407302660814847 0.1375896338762124 0.33046870389926525 1.735426615378574e-07 6.7605937462737415 0.9655957228545037 K(ub)TGQAPGYSYTAANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTGQAPGYSYTAANK 15 1 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 1 5337200.0 1886500.0 1347700.0 2103000.0 True False 2583990.030745586 1288154.157752076 1606314.7126445398 1.0 0.4985135942573243 0.6216412190185784 21.301169073325962 -10.053597227225712 7.418567984881997 1.0000000419201613 0.5600774066379918 0.9445086032010599 0.05026664231765809 3.484266462118117e-08 4.448125469346079e-09 0.048670471855590695 0.01622348904717123 8.83899265019332e-11 10.053597227225712 -0.43992263528216957 K(ub)TGQAPGYSYTAANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTGQAPGYSYTAANK 15 1 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 1 5874900.0 1522100.0 2516900.0 1835900.0 True False 1265693.5904631154 2503340.9601344685 2219778.20175749 1.0 1.9778412239715142 1.7538037788002676 20.271496756852475 -10.049936081373877 5.319757960990335 0.9999923575099764 1.8658225013871452 0.9521847979642006 0.09146290399545026 8.291912495604008e-06 1.4809516106063315e-06 0.0885593577347736 0.029519525330210652 8.913821203851025e-11 10.049936081373877 0.8658301438771688 K(ub)TGQAPGYSYTAANK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTGQAPGYSYTAANK 15 1 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 1 17056300.0 2719600.0 2624700.0 11712000.0 True False 3520575.81133056 2478633.137703271 9580536.175268218 1.0 0.7040419722609242 2.7212980741486623 21.747379978929004 -6.869609851445891 1.1360794152228404 0.8329854467966918 2.8386054158416862 0.9642962864458812 0.16806169485467204 0.13723362687882332 0.33127717236658055 0.11482793862241694 0.27169313294769265 1.350175268219307e-07 6.869609851445891 2.0056199690449943 up K(ub)TIMQLCHDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTIMQLCHDR 10 1 P19388;A0A087WVZ9;A0A0A0MQR7 P19388 POLR2E DNA-directed RNA polymerases I, II, and III subunit RPABC1 1 2436600.0 446840.0 713960.0 1275800.0 True False 585811.5672047148 607439.9509942832 1143792.4543377515 1.0 1.036920376790734 1.9524920953601579 19.16007715482398 -6.915392831965465 0.8582035622737895 0.9762542692555726 2.085548627267301 0.9928024305567192 0.0373768498484553 0.1009589294944396 0.12022330765721596 0.03144158357229029 0.09040554348575335 1.2150864224808174e-07 6.915392831965465 1.1092943580117285 K(ub)TIMQLCHDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTIMQLCHDR 10 1 P19388;A0A087WVZ9;A0A0A0MQR7 P19388 POLR2E DNA-directed RNA polymerases I, II, and III subunit RPABC1 1 33502800.0 1209300.0 4287500.0 28006000.0 True False 1565462.6888667608 4048896.8559846003 22909195.365826648 1.0 2.5863898799885154 14.634136941590492 20.578157693113205 -6.931077757039806 0.7378948181213583 0.8239197308412671 17.1767320481751 0.9967458017455658 0.3472835179119397 0.09208212383947446 0.07496765413273268 0.318444335123667 1.083725550721167 1.1719855118970842e-07 6.931077757039806 16.352812317333832 K(ub)TKFENLCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTKFENLCK 9 2 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 1 5836100.0 2302300.0 2366800.0 1167000.0 True False 3018337.595504917 2013682.6657141417 1046250.0346544569 1.0 0.6671495821782939 0.34663121720134715 21.525322746998604 -7.306133018072772 0.257964345917714 1.111120423770577 2.959821291952412e-11 0.9999303235630316 0.0022266402084302186 0.10635215126469308 0.01720676215651562 0.015588300217989534 0.04832171834670743 4.9415931000825995e-08 7.306133018072772 -1.1111204237409786 down K(ub)TKFENLCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTKFENLCK 9 2 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 1 3533480.0 1726500.0 1133200.0 673780.0 True False 1671693.2025383213 1585692.6695599323 497296.805033274 1.0 0.9485548347939654 0.297480903959035 20.67287867045738 -6.92264172801746 0.8049010965960541 1.0130444607396507 0.18583688033319384 0.9948835701858885 0.022870429314669094 0.09664248469475326 0.0977451726991008 0.019985973329899338 0.061465847940540164 1.194973493405424e-07 6.92264172801746 -0.8272075804064569 down K(ub)TKFENLCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTKFENLCK 9 2 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 1 19878500.0 2990800.0 6433700.0 10454000.0 True False 4537262.256767909 5285555.968272469 8387762.317849023 1.0 1.1649218557707093 1.848639519423326 22.113390620153158 -6.944054084595652 0.6207108527124593 0.992520531466325 2.057306644370053 0.9986480572147912 0.013508920256152464 0.08596500832662095 0.046547707775371386 0.013595718904634247 0.057878650470767345 1.1374856209317591e-07 6.944054084595652 1.064786112903728 K(ub)TKFENLCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTKFENLCK 9 2 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 1 5370900.0 2302300.0 1549500.0 1519100.0 True False 3153522.527318081 1481037.966488713 1160319.8668465626 1.0 0.46964559588805743 0.3679440551938466 21.588532808521496 -13.999999999999998 0.2322147770457179 4.382651983993535 0.31952651669399423 0.9995128971932496 0.0061159457373758195 13.361315031262611 0.15256479942456752 20.864867483577722 0.05207459386013088 1.0000000000000041e-14 13.999999999999998 -4.063125467299541 K(ub)TKFENLCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTKFENLCK 9 2 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 1 4575500.0 1726500.0 1514300.0 1334700.0 True False 1435661.2469184473 1506142.1653349847 1613779.5990444596 1.0 1.049093000572259 1.124067117161748 20.453283945891656 -6.964957171019594 0.3587896571503067 0.9934494930601601 1.1822750630334957 0.999912243491345 0.00047787711915299653 0.07797554486203596 0.014911422678536946 0.001008398565147477 0.006408401796716083 1.084033813315698e-07 6.964957171019594 0.18882556997333566 K(ub)TKFENLCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTKFENLCK 9 2 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 1 14327700.0 2990800.0 4428400.0 6908500.0 True False 3871649.5574817774 4181955.6471235473 5651223.887196079 1.0 1.0801482895170917 1.4596424090799642 21.884516942245607 -6.941027897307734 0.6499344605023188 0.995804339068017 1.565149118586921 0.9982954136261922 0.008276921030735303 0.0873008732837024 0.05249834658659956 0.00812113384868016 0.032517227411213774 1.145439360725519e-07 6.941027897307734 0.569344779518904 K(ub)TLDSVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTLDSVAK 8 1 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 7371600.0 2392400.0 3472600.0 1506600.0 True False 3136459.5680345534 2954501.6160887806 1350711.4843276828 1.0 0.9419861955817285 0.43064846047867256 21.580705534372946 -6.928339176142379 0.7603017319224584 1.008273884124874 0.3299796759540382 0.9962016333695204 0.015766389258125263 0.09350942972678582 0.08197268692161229 0.01422451695354258 0.04669692640013079 1.1793991864288879e-07 6.928339176142379 -0.6782942081708357 down K(ub)TLDSVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTLDSVAK 8 1 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 8549200.0 3344600.0 3879700.0 1324900.0 True False 3238427.503741478 5428884.442368222 977868.9438519764 1.0 1.6763952369154556 0.30195795419913135 21.626862017230565 -6.772900147339564 1.5634686519328618 1.3865235503004194 0.29338645161483257 0.741493651693667 0.2853007163045953 0.2617630853103553 1.2631914519261482 0.14380428457465433 0.3413950837502601 1.686940840972492e-07 6.772900147339564 -1.0931370986855868 K(ub)TLDSVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTLDSVAK 8 1 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 7998400.0 3344600.0 4137500.0 516300.0 True False 2781183.090902654 4115210.4662705525 624255.9428985203 1.0 1.4796618315894225 0.2244569747818772 21.40726729266484 -6.803113532010222 1.4430264841573044 1.2636114233602151 0.20573846474652357 0.841160204163468 0.2061122573912533 0.21633457119195293 0.8889811843795091 0.11234687271306228 0.26081438207982854 1.5735714521852573e-07 6.803113532010222 -1.0578729586136917 down K(ub)TLHEVLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTLHEVLEK 9 1 C9JBT1;Q8N3F0-3;Q8N3F0-2;Q8N3F0 C9JBT1 MTURN Maturin 1 19460250.0 6294700.0 7065370.0 6100180.0 True False 8252412.657961503 6011244.336596561 5468991.890658461 1.0 0.7284226547732343 0.6627143015421386 22.976384533630196 -13.999999999999998 0.19931764468423727 2.5057609191869985 0.6197522477316085 0.9994869122957605 0.0033070144695597917 12.517456105604229 0.14156446559783437 7.345947001000294 0.04205343848070025 1.0000000000000041e-14 13.999999999999998 -1.8860086714553899 K(ub)TLHEVLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTLHEVLEK 9 1 C9JBT1;Q8N3F0-3;Q8N3F0-2;Q8N3F0 C9JBT1 MTURN Maturin 1 59735900.0 11180300.0 22218800.0 26336800.0 True False 10825387.496286808 31090882.709511347 19438401.99293588 1.0 2.8720341623037293 1.7956310570502354 23.367915331562223 -10.606489311420557 6.154082740069637 0.9949486903288043 2.3338326096769824 0.6718457365129578 0.4394397275697325 0.03041458532793425 0.0019447971824549063 0.4249114251110174 0.14182856221162485 2.4746323646614764e-11 10.606489311420557 1.338883919348178 K(ub)TLHEVLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTLHEVLEK 9 1 C9JBT1;Q8N3F0-3;Q8N3F0-2;Q8N3F0 C9JBT1 MTURN Maturin 1 39990100.0 13184400.0 15799700.0 11006000.0 True False 20001698.708750457 12980120.091380453 8830659.275898835 1.0 0.6489508856416198 0.44149546518444194 24.25361919494252 -9.466488798400757 0.12440283262631917 1.6441178659653577 8.869131455210299e-13 0.9998907161693829 0.0024096861869310417 0.9184162274707678 0.04842584429007479 0.41426022192787854 0.21192700521431762 3.415947612015737e-10 9.466488798400757 -1.6441178659644708 K(ub)TLHEVLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTLHEVLEK 9 1 C9JBT1;Q8N3F0-3;Q8N3F0-2;Q8N3F0 C9JBT1 MTURN Maturin 1 18993260.0 6294700.0 4895900.0 7802660.0 True False 8622020.6978713 4679582.949423753 5959832.408826934 1.0 0.5427478213522614 0.6912338322614284 23.039594595153087 -10.365021320219885 5.0186129425654915 1.0002491706900842 0.616990826806784 0.8986959557513485 0.060619160111677436 0.000169110702341539 2.1396644385093336e-05 0.058731940763305825 0.019564749797770356 4.3149789337698225e-11 10.365021320219885 -0.38325834388330027 K(ub)TLHEVLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTLHEVLEK 9 1 C9JBT1;Q8N3F0-3;Q8N3F0-2;Q8N3F0 C9JBT1 MTURN Maturin 1 47334760.0 11180300.0 35776700.0 377760.0 True False 9296914.821269792 35583963.81598108 456747.8694351057 1.0 3.827502402686416 0.04912897216075839 23.1483206069965 -6.706424591829988 1.8081507440591094 2.7446188563843936 0.05898438553238337 0.44803879960952686 1.192183715869695 0.38229392748283175 2.4341653771650695 0.5251691205936465 1.3398924947605633 1.9659633084851708e-07 6.706424591829988 -2.68563447085201 K(ub)TLLGDGPVVTDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTLLGDGPVVTDPK 14 1 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 12416400.0 5019700.0 4093300.0 3303400.0 True False 6580875.310843949 3482595.595558433 2961595.8564503235 1.0 0.5291994500822438 0.45003068992512496 22.64984805641968 -13.999999999999995 0.25084981787447536 4.288272969570855 0.41845451602103384 0.9995442920005297 0.00518224898587651 14.031903528118049 0.15848545861821403 23.261750026529295 0.036364297410235454 1.0000000000000123e-14 13.999999999999995 -3.869818453549821 K(ub)TLLGDGPVVTDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTLLGDGPVVTDPK 14 1 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 15708300.0 4631600.0 6924900.0 4151800.0 True False 4484572.393209666 9690048.682876438 3064319.028669818 1.0 2.160751981069291 0.6833023887204206 22.09653899914962 -6.6971869613813055 1.8406301456355376 1.7227729945223504 0.6878926823458714 0.4042381753180899 0.4902282016193443 0.4014706693062285 2.642250547368486 0.21262451809794675 0.5487760615106444 2.0082280953652448e-07 6.6971869613813055 -1.0348803121764791 K(ub)TLLGDGPVVTDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTLLGDGPVVTDPK 14 1 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 12424900.0 5019700.0 3367400.0 4037800.0 True False 6875618.742291867 3218617.1334973187 3084154.8011013484 1.0 0.4681203618373478 0.4485639644517723 22.71305811794257 K(ub)TLLGDGPVVTDPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTLLGDGPVVTDPK 14 1 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 24811800.0 7577700.0 6549100.0 10685000.0 True False 9809482.02879821 6184636.827878427 8740439.637358347 1.0 0.6304753716579392 0.8910194862173743 23.225745528988565 -10.076301942789053 5.749153418535792 1.0000011705090346 0.7607474289376249 0.5292608365512552 0.10636668935942319 1.5958529338580879e-06 2.5639474191137053e-07 0.10298960823156535 0.03432970137333885 8.3887655567095e-11 10.076301942789053 -0.23925374157140966 K(ub)TNLIVDSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTNLIVDSR 9 1 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 1 1789740.0 606650.0 583540.0 599550.0 True False 795324.0248069576 496478.1066211041 537514.3172896998 1.0 0.6242463337400252 0.6758431790365772 19.60118322633428 -10.136963438914641 5.192256794088679 1.0000115585952813 0.6500447563881849 0.9839579769995336 0.021064323886792007 2.8185453870022745e-06 4.6846657930501163e-07 0.02039611729944187 0.006798481300890443 7.29518922227407e-11 10.136963438914641 -0.3499668022070964 K(ub)TNLIVDSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTNLIVDSR 9 1 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 1 3567800.0 606650.0 1770950.0 1190200.0 True False 830944.8990998195 1692703.5732514923 909099.2729384373 1.0 2.0370828138968475 1.094054821111826 19.66439328785717 -6.623476540822539 2.1038596465897186 1.6864466007541858 1.0977137791142082 0.09462491065566558 0.44558684583861186 0.5761664553821525 4.850721640808133 0.1737327337435298 0.4939489546408302 2.3797068415197364e-07 6.623476540822539 -0.5887328216399776 K(ub)TNLIVDSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTNLIVDSR 9 1 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 1 4392020.0 1473300.0 2299700.0 619020.0 True False 1225114.2282565585 2287311.0596452905 748454.2199749021 1.0 1.8670186068284653 0.6109260693511135 20.224484840067372 -6.721008921587467 1.7558404683080866 1.526915802137614 0.612792315954344 0.5172220262664886 0.3647995716170145 0.35335238540257935 2.129568980404371 0.16493830176547294 0.41354196876185084 1.901039227016447e-07 6.721008921587467 -0.9141234861832699 K(ub)TPQGPPEIYSDTQFPSLQSTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTPQGPPEIYSDTQFPSLQSTAK 23 1 Q9UKY7;Q9UKY7-2;H0Y8K3;D6R9V8;D6RFH2;Q9UKY7-3;D6RDN0 Q9UKY7 CDV3 Protein CDV3 homolog 1 9355000.0 3234100.0 3288900.0 2832000.0 True False 3131435.26575684 4602174.921386928 2090214.2418211186 1.0 1.4696695064123013 0.6674939969790282 21.57839262462423 -6.7479950515320155 1.657106083755485 1.2768295091245392 0.6661238682620065 0.6403831916661591 0.19734212041024665 0.30354530526115087 1.6393208016038252 0.09409719891923661 0.2289397419528806 1.7865079306873243e-07 6.7479950515320155 -0.6107056408625327 K(ub)TQAASVEAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTQAASVEAVK 11 1 A0A087WWF6;P49005;F8W8R3;C9JHC7;H7C1B3 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 9534300.0 1667300.0 1925600.0 5941400.0 True False 1614372.4741338782 2694502.1218713396 4385169.101820618 1.0 1.6690709021887642 2.71633044547126 20.62254205041162 -6.964540241298454 0.36586174839270574 0.9155902589712872 3.506028624692956 0.9999033461127635 0.0069441810270815755 0.07811738081222905 0.015412493279816683 0.013896745234546563 0.08914551780658679 1.0850750029947457e-07 6.964540241298454 2.5904383657216687 K(ub)TQAASVEAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTQAASVEAVK 11 1 A0A087WWF6;P49005;F8W8R3;C9JHC7;H7C1B3 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 7716900.0 1667300.0 2917600.0 3132000.0 True False 1386433.8239137707 2901882.3097017417 3786886.7192681856 1.0 2.0930550450002756 2.731386564544541 20.402947325845897 -8.84786642773103 0.18572163265773345 3.575702875944838e-16 3.5217706095151944 0.9996955621325426 0.012473947850307995 0.3617339402241049 0.05741381637374857 0.5794678695595615 0.3663072220667371 1.41949403629496e-09 8.84786642773103 3.521770609515194 K(ub)TQAASVEAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTQAASVEAVK 11 1 A0A087WWF6;P49005;F8W8R3;C9JHC7;H7C1B3 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 21648600.0 1662600.0 2251000.0 17735000.0 True False 2152268.474745623 2125729.8712119716 14507411.976467032 1.0 0.9876694734671576 6.740521522614258 21.037426620743545 -6.906413063428864 0.9197963740776053 0.8010504366809319 7.4296914255619 0.9894965742553563 0.27763710343700915 0.10683857786491777 0.1519797832057362 0.2233485888071968 0.6022598486705865 1.2404719165118123e-07 6.906413063428864 6.628640988880969 up K(ub)TQAHTQQNMVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTQAHTQQNMVEK 13 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 11160700.0 3418500.0 3638800.0 4103400.0 True False 3309981.588692293 5091791.816091314 3028596.440638693 1.0 1.5383142412290511 0.9149889083930616 21.658391761590444 -6.678267451994133 1.908010434543781 1.341137210815922 0.9173965575246125 0.3161046151501008 0.2282396619045507 0.4424583241609117 3.112738193564414 0.09603765393171194 0.25385952345984664 2.0976476893564504e-07 6.678267451994133 -0.4237406532913096 K(ub)TQAHTQQNMVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTQAHTQQNMVEK 13 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 8734500.0 3418500.0 4191500.0 1124500.0 True False 2842634.215227747 4168919.557552395 1359627.7508994502 1.0 1.4665691193118875 0.47829852452209337 21.43879703702472 -6.77832146290954 1.5423071544567644 1.264764114205384 0.4708664182091071 0.761415728473103 0.19717248121164646 0.2532047402603384 1.189527670367957 0.1007008973476737 0.237957642491177 1.6660135799488315e-07 6.77832146290954 -0.7938976959962769 down K(ub)TQETLSQAGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTQETLSQAGQK 12 1 O43399;O43399-5;O43399-7;A0A087WYR3;O43399-2;O43399-4;O43399-3;O43399-6 O43399;O43399-2 TPD52L2 Tumor protein D54 1 3326120.0 1140400.0 1195400.0 990320.0 True False 1562036.698151213 1142583.275340827 756426.8122806196 1.0 0.7314701867716422 0.4842567483695532 20.57499691756644 -6.972116071909074 0.20133146416704667 1.1446429496532418 0.06424860053863887 0.9999945227750653 0.0004928696058134449 0.07562190251262638 0.0065113953277153806 0.007938952206512424 0.026157001633127917 1.066311095031087e-07 6.972116071909074 -1.0803943491146029 down K(ub)TQETLSQAGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTQETLSQAGQK 12 1 O43399;O43399-5;O43399-7;A0A087WYR3;O43399-2;O43399-4;O43399-3;O43399-6 O43399;O43399-2 TPD52L2 Tumor protein D54 1 4926500.0 2079600.0 2579900.0 267000.0 True False 1729279.541900725 2566001.566629947 322828.46553148294 1.0 1.4838558512116238 0.18668379386287562 20.721739672032232 -6.8056739898552765 1.432515743003542 1.2650740230227202 0.16613779051560537 0.8482742756882538 0.20848331123335262 0.21275076354363245 0.861220063420704 0.11446041679469036 0.2653419172190358 1.5643214851114025e-07 6.8056739898552765 -1.0989362325071148 down K(ub)TQGFILNTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTQGFILNTK 10 1 Q8IWA0 Q8IWA0 WDR75 WD repeat-containing protein 75 1 5548800.0 2169900.0 1115900.0 2263000.0 True False 3291896.94093911 916758.9264335042 1815717.0580918668 1.0 0.2784895587198948 0.5515716593405504 21.65048773949336 -10.364342355245084 5.849604629513217 1.000111888960819 0.4150306090311023 0.8595136222938816 0.11148530073466682 0.00016271030615611274 1.7681162450011524e-05 0.10796557722833455 0.03598172609102366 4.3217301383181996e-11 10.364342355245084 -0.5850812799297167 K(ub)TRPDGNCFYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTRPDGNCFYR 11 2 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 51378000.0 13031000.0 21878000.0 16469000.0 True False 17083767.192383524 18613887.679776076 14764945.86180312 1.0 1.0895657538622234 0.8642675643804016 24.026122807231513 -6.798814274091146 1.4605971781001301 1.0494911574637633 0.861242062456675 0.8287323155257538 0.03832992962340336 0.22244371210626168 0.9369716704235238 0.020645634098311938 0.04805246761851923 1.5892262354335412e-07 6.798814274091146 -0.1882490950070883 K(ub)TRPDGNCFYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTRPDGNCFYR 11 2 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 42098000.0 17303000.0 12301000.0 12494000.0 True False 16753725.736183364 17212853.448867567 9221446.588034257 1.0 1.0274045140713157 0.5504116954784876 23.997978625656977 -6.893277504603631 1.0027719825899146 1.0236520950687917 0.5066481456775688 0.9829152049247895 0.028583879182253306 0.11652494453181865 0.2066267210708309 0.021619982972770367 0.05457655680020716 1.2785640688226702e-07 6.893277504603631 -0.517003949391223 K(ub)TRPDGNCFYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTRPDGNCFYR 11 2 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 44919000.0 13031000.0 15920000.0 15968000.0 True False 17848912.849533916 15216601.759600071 12196687.27128296 1.0 0.8525226095211406 0.6833294203462621 24.089332868754404 -6.969329714008842 0.273723480699285 1.0402063272686088 0.4905337705499265 0.9999766698942939 0.0006249021634225594 0.07652083041318453 0.009806016144574527 0.0032426192667789 0.015656758340025927 1.073174354852814e-07 6.969329714008842 -0.5496725567186824 K(ub)TRPDGNCFYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTRPDGNCFYR 11 2 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 67391000.0 25857000.0 24387000.0 17147000.0 True False 33472396.217669588 23029842.01210412 14026421.94307755 1.0 0.688024898556471 0.41904445238590976 24.996468498403168 -7.251228863440462 0.2023313620235692 1.1742413023382199 1.5967909797934142e-15 0.9999827043024906 0.0009872450610489325 0.09930228235231926 0.011026758184305367 0.016388546412694268 0.04229182037810608 5.6075239423600824e-08 7.251228863440462 -1.1742413023382183 down K(ub)TSATVGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTSATVGPK 9 1 P16104 P16104 H2AFX Histone H2AX 1 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 K(ub)TSETLSQAGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTSETLSQAGQK 12 1 P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;H0YC42 P55327-2 TPD52 Tumor protein D52 1 8931850.0 4448100.0 3654600.0 829150.0 True False 5831502.17546168 3109347.9255192266 743357.5117684177 1.0 0.5331984507530532 0.1274727316224599 22.475436134042543 -7.915992682903998 0.4016289987011743 1.055678092264345 7.797623891804534e-19 0.9976264899742121 0.0173681382171232 0.10453791366742994 0.08139400518825954 0.04093164760301653 0.08116421469151365 1.2134092940991239e-08 7.915992682903998 -1.055678092264345 down K(ub)TSETLSQAGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTSETLSQAGQK 12 1 P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;H0YC42 P55327-2 TPD52 Tumor protein D52 1 11530750.0 4403100.0 5234700.0 1892950.0 True False 4263326.000635089 7324943.008599872 1397129.6077172628 1.0 1.7181287585112437 0.32770883753884605 22.02354794635188 -6.766319106803626 1.5884132804903444 1.4138350229330132 0.32093100132800073 0.7163152286924366 0.30238971722399877 0.27243240767999705 1.3559198519468332 0.15010368994406753 0.35854812034528 1.712698404681184e-07 6.766319106803626 -1.0929040216050125 K(ub)TSETLSQAGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTSETLSQAGQK 12 1 P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;H0YC42 P55327-2 TPD52 Tumor protein D52 1 8336900.0 4448100.0 2797100.0 1091700.0 True False 6092682.775382687 2673514.8732272233 833862.9442672599 1.0 0.4388074961049153 0.13686301667246809 22.538646195565434 -8.724065793924437 0.303847166283822 1.2024670495632783 4.518098204254021e-26 0.9986157141238787 0.013306093403116755 0.285536625525795 0.09425639672283048 0.15914817154497865 0.09576297903880715 1.8877053474165314e-09 8.724065793924437 -1.2024670495632783 K(ub)TSETLSQAGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTSETLSQAGQK 12 1 P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;H0YC42 P55327-2 TPD52 Tumor protein D52 1 12436640.0 4403100.0 7499000.0 534540.0 True False 3661372.7404034836 7458601.398565052 646309.8425662885 1.0 2.0371051863305 0.17652118164157882 21.803953221786156 -6.755408836698675 1.6295990173123924 1.6058301948890057 0.1711882974788294 0.6720082991543326 0.4359706021187569 0.2906997205626635 1.5203406870102187 0.21119143965324394 0.5098846784168758 1.7562695162535328e-07 6.755408836698675 -1.4346418974101762 K(ub)TSYAQHQQVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTSYAQHQQVR 11 1 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6;H0Y8L7;D6RAS7 P61247 RPS3A 40S ribosomal protein S3a 1 9439500.0 1258800.0 2821200.0 5359500.0 True False 1218840.0830322825 3947719.872363647 3955686.168446423 1.0 3.238915364961038 3.245451329927793 20.217077420015052 K(ub)TSYLTELIDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTSYLTELIDR 11 1 B4DR80;Q9Y6E0-2;Q9Y6E0;H0Y630;Q5JV98;Q5JV99;Q8NBY1;B4E0Y9;Q9P289;Q9P289-2;Q9P289-3 B4DR80;Q8NBY1 STK24;STK26 Serine/threonine-protein kinase 24;Serine/threonine-protein kinase 24 36 kDa subunit;Serine/threonine-protein kinase 24 12 kDa subunit;Serine/threonine-protein kinase 26 1 20171700.0 9119200.0 9909200.0 1143300.0 True False 7583018.849058027 9855817.172777807 1382358.7439780685 1.0 1.2997220986734208 0.18229662506374844 22.854340878342942 -6.835303464241472 1.303849959601177 1.1596736977664968 0.1487942905452516 0.9160949555139033 0.1367913283151254 0.17436375399200307 0.5777909999376677 0.0823191922938142 0.18949311009274894 1.4611558317570407e-07 6.835303464241472 -1.0108794072212453 down K(ub)TTEEEDEDELHIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTTEEEDEDELHIGR 15 1 A0A590UJJ9;A0A590UK84;A0A590UJF9;A0A590UJ57;E9PP15;A0A590UJ98;A0A590UKB1;H0YCA4;A0A590UK97;A0A590UJJ8;A0A590UJT0;A0A590UK53;A0A590UJH5;A0A590UJV3;Q14114-4;Q14114-2;Q14114-3;Q14114 A0A590UJJ9 LRP8 Low-density lipoprotein receptor-related protein 8 1 9991350.0 484950.0 1135100.0 8371300.0 True False 469555.52769820933 1588351.3494683027 6178605.396383156 1.0 3.3826698990309 13.15841265179236 18.84093624956387 -6.944291527135112 0.6183494431850179 0.8928755365673254 16.16464514028131 0.9986737084805655 0.1915835899829503 0.08586218011157472 0.046095528936505446 0.19323090433415818 0.8268127869976735 1.1368638915143861e-07 6.944291527135112 15.271769603713983 K(ub)TTEEEDEDELHIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTTEEEDEDELHIGR 15 1 A0A590UJJ9;A0A590UK84;A0A590UJF9;A0A590UJ57;E9PP15;A0A590UJ98;A0A590UKB1;H0YCA4;A0A590UK97;A0A590UJJ8;A0A590UJT0;A0A590UK53;A0A590UJH5;A0A590UJV3;Q14114-4;Q14114-2;Q14114-3;Q14114 A0A590UJJ9 LRP8 Low-density lipoprotein receptor-related protein 8 1 22751800.0 11332800.0 6282100.0 5136900.0 True False 17192686.138658322 5161010.172728669 4121589.4634167505 1.0 0.30018637757388983 0.2397292331271738 24.03529162939832 -13.999999999999998 0.3467758000506658 9.436968668049424 0.23101659599721627 0.9997485184462991 0.005471527292090691 20.343190556178282 0.1893416028500541 126.23546991964884 0.018239403853540562 1.0000000000000041e-14 13.999999999999998 -9.205952072052208 K(ub)TTEEEDEDELHIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTTEEEDEDELHIGR 15 1 A0A590UJJ9;A0A590UK84;A0A590UJF9;A0A590UJ57;E9PP15;A0A590UJ98;A0A590UKB1;H0YCA4;A0A590UK97;A0A590UJJ8;A0A590UJT0;A0A590UK53;A0A590UJH5;A0A590UJV3;Q14114-4;Q14114-2;Q14114-3;Q14114 A0A590UJJ9 LRP8 Low-density lipoprotein receptor-related protein 8 1 5554350.0 484950.0 3732600.0 1336800.0 True False 403257.41192765743 3712491.7429369064 1616318.6993351546 1.0 9.206257921436322 4.00815620873229 18.621341524998147 -9.34814905187937 10.251970272240852 0.9999999999999941 6.6072070650843155 0.6080685231185132 2.122116137868734 0.0 0.0 2.0547300080083675 0.6849100383902955 4.485914048608461e-10 9.34814905187937 5.607207065084322 K(ub)TTHFVEGGDAGNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTTHFVEGGDAGNR 14 1 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 1 3679600.0 1143800.0 1026500.0 1509300.0 True False 1107490.695084467 1436386.8031267817 1113969.0519705557 1.0 1.2969741502137226 1.0058495813236557 20.078863146919918 -10.71920740637394 4.894269861527582 0.9936043434589495 1.1514118657684824 0.26506382717619126 0.11885110756140213 0.008600580290251182 0.0004934293912285527 0.11932697115829212 0.03835903002196763 1.9089413861294157e-11 10.71920740637394 0.15780752230953288 K(ub)TTHFVEGGDAGNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTTHFVEGGDAGNR 14 1 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 1 2844470.0 1143800.0 1230500.0 470170.0 True False 951120.3789315496 1223871.0522648739 568480.3731795416 1.0 1.2867677734333918 0.597695502874357 19.859268422354194 -6.793670132102005 1.4816072643286642 1.1595122890028882 0.5896042719349945 0.8130100280874991 0.12221478080321492 0.22992048679700017 0.9969448176001897 0.06491439814473544 0.15158638017372755 1.6081622671325937e-07 6.793670132102005 -0.5699080170678936 K(ub)TTHFVEGGDAGNREDQINR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTTHFVEGGDAGNREDQINR 20 2 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 1 7098500.0 1577000.0 2004200.0 3517300.0 True False 1526938.9982061575 2804487.511764925 2596013.613261801 1.0 1.836672922140064 1.7001423215410627 20.542210996394502 -10.386084108124072 5.614996089940667 0.9997255543630605 1.7684076218405669 0.9768700478028516 0.05573838429055933 0.00019156292745291277 2.0944478550195288e-05 0.05398704639610563 0.017989486175151937 4.1107010304621216e-11 10.386084108124072 0.7686820674775063 K(ub)TTHFVEGGDAGNREDQINR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTTHFVEGGDAGNREDQINR 20 2 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 1 5693200.0 1813100.0 1313400.0 2566700.0 True False 2483452.0671851686 1255369.6451670076 1960498.3228458127 1.0 0.5054938091033452 0.7894246676836046 21.243915471081568 -10.202558488539335 5.621841827624908 1.0000115909569864 0.6474592383934595 0.6727287945621531 0.11591428762538743 1.684034569861226e-05 2.388956188140715e-06 0.11223721323392755 0.037411175463376495 6.272512153391544e-11 10.202558488539335 -0.3525523525635269 K(ub)TTHFVEGGDAGNREDQINR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTTHFVEGGDAGNREDQINR 20 2 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 1 7522100.0 1577000.0 4458000.0 1487100.0 True False 1311345.3729454908 4433983.86915628 1798045.7344264735 1.0 3.3812479615471895 1.371145825899226 20.322616271828778 -6.604577375594968 2.1727812549180032 2.596543622746443 1.3778059525414335 0.03423674029919099 1.028019544580302 0.6276691553946999 5.606481427855058 0.3917058134437003 1.1430449969393097 2.4855506893938135e-07 6.604577375594968 -1.2187376702050094 K(ub)TTPGFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTTPGFR 7 1 Q15274 Q15274 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] 1 3005090.0 242990.0 475100.0 2287000.0 True False 318562.2431185071 404216.9319252949 2050363.178453079 1.0 1.2688789731271568 6.436303180130269 18.281215759210806 -6.9176805682251405 0.8417456040388563 0.876176373812632 7.226718403047191 0.993512079719339 0.20150856637823883 0.09955592911768289 0.11282640802231969 0.17152060966964097 0.5029294975560216 1.2087025317278523e-07 6.9176805682251405 6.350542029234559 up K(ub)TTPGFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTTPGFR 7 1 Q15274 Q15274 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] 1 6494860.0 499220.0 955840.0 5039800.0 True False 483372.53435921215 1337511.8966397494 3719725.1892408445 1.0 2.7670415705617946 7.6953590136682815 18.882775974703137 -6.953077660884043 0.5239692888636331 0.9187507860267633 9.765079936699001 0.9994211927079303 0.06816011963915694 0.08227297088157914 0.031026343896275593 0.07673779103812936 0.4072505214674354 1.1140952923733552e-07 6.953077660884043 8.846329150672238 K(ub)TTPGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTTPGFR 7 1 Q15274 Q15274 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] 1 3454420.0 499220.0 1284900.0 1670300.0 True False 415123.549195845 1277977.9886673177 2019552.00740538 1.0 3.0785485216219315 4.864942042718481 18.663181250137413 -7.376395521329717 0.21924168111879258 4.753798768093129e-15 7.27143589353769 0.9999524918592904 0.010885904417152464 0.1219540587544507 0.017111811248370207 0.14402471770847833 0.35562307686331174 4.2034363801613305e-08 7.376395521329717 7.271435893537686 K(ub)TVGVEPAADGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTVGVEPAADGK 12 1 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 1 5959800.0 1107400.0 1301900.0 3550500.0 True False 1072246.1931601143 1821755.459318812 2620517.537283147 1.0 1.699008558799123 2.443951355574396 20.032204763247027 -6.970317216908002 0.250496772847711 0.765030089030364 3.399761906302165 0.9999847512774189 0.0023023192267327686 0.07619991510034357 0.008661218619963685 0.016559213529814747 0.07133785019606029 1.070736933024564e-07 6.970317216908002 2.6347318172718013 K(ub)TVGVEPAADGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTVGVEPAADGK 12 1 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 1 4492800.0 1107400.0 1743300.0 1642100.0 True False 920852.1661381343 1733908.4968820445 1985455.5177874502 1.0 1.8829390434663384 2.156106692037273 19.812610038681303 -10.548433136896898 0.24832561658616703 8.092836315305717e-11 2.29873933716891 0.9991714737219849 0.014201417427456472 2.218558179814705 0.12416063201318958 1.4951931799955642 0.12526884699086016 2.8285695583944676e-11 10.548433136896898 2.298739337087982 K(ub)TVGVEPAADGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTVGVEPAADGK 12 1 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 1 5508790.0 752190.0 1232000.0 3524600.0 True False 973724.7828815766 1163438.1169849606 2883158.9654499968 1.0 1.1948326030502776 2.9609588008202556 19.893154535780283 -6.9278480422810516 0.7642449881219898 0.9708896052231575 3.3044399671846008 0.9960982152163231 0.055098224641763255 0.09377074844644821 0.08326661623678727 0.049568967755438155 0.16173621981197306 1.1807336968831925e-07 6.9278480422810516 2.3335503619614433 up K(ub)TYQAYHMESVNAEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTYQAYHMESVNAEAK 16 1 E7EQN5;P98171;P98171-2;A0A0B4J1X7;S4R314;S4R352;C9JLA8;C9J5M2;H7C3G3 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 1 26839500.0 1628300.0 2620200.0 22591000.0 True False 2470250.1446754006 2152604.8382839584 18125878.94801296 1.0 0.8714116839235397 7.337669420679161 21.236225710004607 -6.902366633869349 0.9462148298146285 0.7483348155441721 8.049926644783415 0.9877065865336692 0.3346639098158305 0.10968318876190863 0.16777035354861414 0.2640475770452262 0.6955108273748487 1.2520837124617153e-07 6.902366633869349 7.301591829239243 up K(ub)TYQAYHMESVNAEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTYQAYHMESVNAEAK 16 1 E7EQN5;P98171;P98171-2;A0A0B4J1X7;S4R314;S4R352;C9JLA8;C9J5M2;H7C3G3 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 1 13247800.0 1628300.0 2909500.0 8710000.0 True False 2107866.4485915406 2747583.7673439486 7124869.372147057 1.0 1.3034904413322115 3.3801332038411815 21.007352032097057 -6.933123080690166 0.7207029838984059 0.9717869279805841 3.84245852082975 0.9971171131024922 0.05679346237654129 0.09104845832405012 0.06997344633558573 0.05273840842315658 0.18477991249187645 1.1664789856787717e-07 6.933123080690166 2.870671592849166 up K(ub)VAAIEALNDGELQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVAAIEALNDGELQK 15 1 P50502;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P4 Hsc70-interacting protein;Putative protein FAM10A4 1 5758500.0 1370700.0 1854200.0 2533600.0 True False 1797000.9738776803 1577560.5876149898 2271447.376007311 1.0 0.8778852157274193 1.2640212270479971 20.7771597600352 -6.821664164212261 1.3645987143751057 0.9342888043558578 1.2727598273080163 0.8881801069463937 0.053887303061825674 0.1913279465858474 0.6995984095956852 0.031027759193111466 0.07148632347566215 1.5077725616611267e-07 6.821664164212261 0.3384710229521585 K(ub)VAAIEALNDGELQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVAAIEALNDGELQK 15 1 P50502;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P4 Hsc70-interacting protein;Putative protein FAM10A4 1 8699800.0 2630100.0 1888900.0 4180800.0 True False 2546608.915143956 2643147.6204833733 3085723.058688464 1.0 1.0379087282563606 1.2116988361811467 21.280145990065556 -6.9417578161342774 0.6430018731179802 0.9980930191975151 1.2610918544388081 0.9983851994094912 0.003703776664824326 0.08697374794567181 0.05102579346939508 0.003655317821767135 0.014845766661186068 1.1435158374382276e-07 6.9417578161342774 0.26299883524129297 K(ub)VAAIEALNDGELQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVAAIEALNDGELQK 15 1 P50502;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P4 Hsc70-interacting protein;Putative protein FAM10A4 1 28540800.0 9776500.0 11633000.0 7131300.0 True False 14831665.25788801 9557000.260956151 5721795.429240169 1.0 0.644364614140236 0.38578240067797603 23.822177252861874 -7.881206349886437 0.1864226609122763 1.261805676317575 1.2834642597761786e-12 0.999903249081449 0.0024766961458131563 0.11874410034107995 0.028617231026559563 0.06873304510443307 0.0975080678848084 1.3146000671057333e-08 7.881206349886437 -1.2618056763162915 down K(ub)VAAIEALNDGELQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVAAIEALNDGELQK 15 1 P50502;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P4 Hsc70-interacting protein;Putative protein FAM10A4 1 27524800.0 9776500.0 13090000.0 4658300.0 True False 12655871.973625986 12361529.99296523 3810537.198194329 1.0 0.9767426550083514 0.3010884754630294 23.593303574954323 -6.914208398279616 0.8665969513813908 1.0182395661827606 0.20543437579520413 0.9924148126552694 0.028229215699182457 0.10170047917502853 0.12416315218709319 0.023603697832477982 0.06722182164327399 1.2184048012689385e-07 6.914208398279616 -0.8128051903875564 down K(ub)VASHTPSLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVASHTPSLLR 11 1 P55957-4;P55957;P55957-2 P55957-4 BID BH3-interacting domain death agonist;BH3-interacting domain death agonist p15;BH3-interacting domain death agonist p13;BH3-interacting domain death agonist p11 1 20227900.0 4459200.0 7863200.0 7905500.0 True False 4317645.1368426755 11003016.76604628 5834812.390083626 1.0 2.5483837641396243 1.3513876673872265 22.04181324382044 -6.5811709044919855 2.2621607244979134 2.053652897868623 1.3543944158575028 0.0 0.6724625172692739 0.6958328832093248 6.699181627906836 0.24941807990231774 0.7515213748339091 2.623186058465202e-07 6.5811709044919855 -0.6992584820111203 K(ub)VASHTPSLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVASHTPSLLR 11 1 P55957-4;P55957;P55957-2 P55957-4 BID BH3-interacting domain death agonist;BH3-interacting domain death agonist p15;BH3-interacting domain death agonist p13;BH3-interacting domain death agonist p11 1 80279000.0 22699000.0 32908000.0 24672000.0 True False 34436042.519183755 27035310.28862244 19795568.38587826 1.0 0.7850876091107598 0.5748502713356355 25.03741601815398 -6.971395124992312 0.22235281263271198 1.094117342101066 0.2598676793212838 0.9999913137926888 0.0005115198207987342 0.07585254078936206 0.007389022897801717 0.005719918714177028 0.02120376088472749 1.0680826858827468e-07 6.971395124992312 -0.8342496627797822 K(ub)VASHTPSLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVASHTPSLLR 11 1 P55957-4;P55957;P55957-2 P55957-4 BID BH3-interacting domain death agonist;BH3-interacting domain death agonist p15;BH3-interacting domain death agonist p13;BH3-interacting domain death agonist p11 1 12063200.0 3580600.0 4079000.0 4403600.0 True False 4904444.582076665 3898776.2925508027 3363560.374988823 1.0 0.7949475679262265 0.6858188157087112 22.225658332872747 -13.999999999646228 0.07845630920324591 2.116326380677949 0.3504213898209816 0.9998929746495753 0.0013473747344077017 12.273918151575431 0.07835985213158822 2.395184349176121 0.3051934945650019 1.0000000008145904e-14 13.999999999646228 -1.7659049908569675 K(ub)VASHTPSLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVASHTPSLLR 11 1 P55957-4;P55957;P55957-2 P55957-4 BID BH3-interacting domain death agonist;BH3-interacting domain death agonist p15;BH3-interacting domain death agonist p13;BH3-interacting domain death agonist p11 1 12950900.0 4459200.0 6433100.0 2058600.0 True False 3708022.3760548728 6398443.61342962 2489043.742109033 1.0 1.725567692025959 0.6712590943847635 21.822218519254715 -6.721535462152771 1.7538845638252647 1.440709542188328 0.6727728680946888 0.5196754777759222 0.3052663261252605 0.3523615043823954 2.1191341613753694 0.13815787228069723 0.34619080267537966 1.8987357952132284e-07 6.721535462152771 -0.7679366740936392 K(ub)VASHTPSLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVASHTPSLLR 11 1 P55957-4;P55957;P55957-2 P55957-4 BID BH3-interacting domain death agonist;BH3-interacting domain death agonist p15;BH3-interacting domain death agonist p13;BH3-interacting domain death agonist p11 1 74781000.0 22699000.0 29012000.0 23070000.0 True False 29384302.964183122 27397456.696402386 18871496.71818974 1.0 0.9323840939768921 0.6422305385699444 24.80854234024643 -6.943263838681499 0.62847080807129 1.0031652722188318 0.555852725953885 0.9985608557566151 0.005887355410762651 0.0863088309365363 0.0480632938671889 0.0058840150698365335 0.024636519736999183 1.1395572836285838e-07 6.943263838681499 -0.44731254626494676 K(ub)VCSTNDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVCSTNDLK 9 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 3514580.0 1302300.0 1556200.0 656080.0 True False 1707327.9114911405 1324021.0260200878 588195.1351637503 1.0 0.7754931065724326 0.3445121064353914 20.703308740079635 -6.960838840976349 0.4234502333510036 1.0183572253902675 0.08529805783700242 0.9998000454958887 0.0038460929322660826 0.0794028791518866 0.020034509879771806 0.005588462242059427 0.035842575706066304 1.0943623895175747e-07 6.960838840976349 -0.9330591675532651 down K(ub)VCSTNDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVCSTNDLK 9 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 3006570.0 1302300.0 799960.0 904310.0 True False 1783795.5033342033 764615.1220860356 690730.602849065 1.0 0.42864505525260366 0.38722521811383503 20.766518801602526 -13.999999999999998 0.3724604212101503 9.082691677401746 0.38309579927959775 0.9997950824764037 0.004002651093612162 23.109988652439135 0.1983159800457977 149.2987299353056 0.01148758825009977 1.0000000000000041e-14 13.999999999999998 -8.699595878122148 K(ub)VDWLTEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVDWLTEK 8 1 P38919;I3L3H2;P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3QL43;J3QL52;Q14240-2;Q14240;E7EQG2;J3KTN0 P38919;P60842;Q14240-2;J3KTN0 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 27678400.0 8313800.0 9689000.0 9675600.0 True False 10899472.31095373 8243438.967426199 8674461.726908868 1.0 0.756315418971405 0.795860705861074 23.377754954002857 -10.113164288237712 4.986846452081285 1.000008463767467 0.7760880624154753 0.9771411906688566 0.01614429577125887 1.5192464398890265e-06 2.7018421794736924e-07 0.015632237972340486 0.005210549054482271 7.706119009567522e-11 10.113164288237712 -0.22392040135199176 K(ub)VDWLTEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVDWLTEK 8 1 P38919;I3L3H2;P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3QL43;J3QL52;Q14240-2;Q14240;E7EQG2;J3KTN0 P38919;P60842;Q14240-2;J3KTN0 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 25876800.0 8363700.0 5703100.0 11810000.0 True False 8098198.921557914 7980377.5712736 8716606.707594424 1.0 0.9854509192197458 1.076363620111908 22.949169650671518 -6.865924665182687 1.1555112896134683 0.9919439294164833 1.081289640417223 0.9604397047154731 0.007930505283484776 0.14081816229769936 0.35398720366195274 0.00533875507738845 0.012557045546400592 1.3616808657168612e-07 6.865924665182687 0.08934571100073962 K(ub)VDWLTEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVDWLTEK 8 1 P38919;I3L3H2;P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3QL43;J3QL52;Q14240-2;Q14240;E7EQG2;J3KTN0 P38919;P60842;Q14240-2;J3KTN0 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 103107000.0 13271000.0 15509000.0 74327000.0 True False 20133077.240058467 12741297.777629942 59636235.87131865 1.0 0.6328539659242345 2.9621023731365503 24.263064362038378 -6.866584112856952 1.1519252215719462 0.7960586054571424 3.0899930792740724 0.9611581786567771 0.20152283993991954 0.14017695104305808 0.3497736176520729 0.13602685611083679 0.3202929345378532 1.359614811650549e-07 6.866584112856952 2.29393447381693 up K(ub)VDWLTEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVDWLTEK 8 1 P38919;I3L3H2;P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3QL43;J3QL52;Q14240-2;Q14240;E7EQG2;J3KTN0 P38919;P60842;Q14240-2;J3KTN0 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 30708100.0 8313800.0 9925300.0 12469000.0 True False 11387636.53199716 9486767.42742202 9524079.007115921 1.0 0.8330760646220094 0.8363525636206438 23.440965015525748 -10.106609917710461 5.44298871451123 1.0000022673732416 0.834714314121275 0.9997053605021492 0.0013376251151296478 3.680407350029496e-08 6.042048830805853e-09 0.0012951677029331187 0.00043171664949709934 7.82330176244328e-11 10.106609917710461 -0.16528795325196666 K(ub)VDWLTEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVDWLTEK 8 1 P38919;I3L3H2;P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3QL43;J3QL52;Q14240-2;Q14240;E7EQG2;J3KTN0 P38919;P60842;Q14240-2;J3KTN0 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 25352200.0 8363700.0 10066000.0 6922500.0 True False 6954787.124733159 10011772.460055443 8369962.743976381 1.0 1.439551244415633 1.203482233727969 22.729574926105794 -10.122702918489805 4.350999022692923 0.9999551473232183 1.321516739059643 0.7120851910761743 0.09637477015055344 67235963.80537355 3.4374305333515487 32997.82879294399 0.03299164722514222 7.53871077017719e-11 10.122702918489805 0.3215615917364246 K(ub)VDWLTEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVDWLTEK 8 1 P38919;I3L3H2;P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3QL43;J3QL52;Q14240-2;Q14240;E7EQG2;J3KTN0 P38919;P60842;Q14240-2;J3KTN0 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 83025000.0 13271000.0 11027000.0 58727000.0 True False 17179571.11051913 10413337.756487973 48039288.58990578 1.0 0.6061465498467443 2.796303137072561 24.034190684130827 -6.86037350944585 1.183733075307686 0.7860729525667224 2.9031775360827927 0.9541003665616821 0.20423169412148356 0.14642352676144962 0.3896362207568583 0.13453851199504602 0.3142100370395189 1.3791975930357325e-07 6.86037350944585 2.1171045835160704 up K(ub)VDWLTEK(ub)MHAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVDWLTEKMHAR 12 2 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3QL43;J3QL52;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 2 4396700.0 1341700.0 1738600.0 1316400.0 True False 1758981.6930412836 1479207.6570097196 1180191.5558004503 1.0 0.8409454531912529 0.6709515854937047 20.746309037070947 -6.970279877678505 0.251416327400143 1.0530168005848934 0.4538923852072357 0.9999844808745562 0.0005292635035080298 0.07621203016062279 0.008704832580437107 0.0037553965096692858 0.016254858819119433 1.0708289954671821e-07 6.970279877678505 -0.5991244153776578 K(ub)VDWLTEK(ub)MHAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVDWLTEKMHAR 12 2 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3QL43;J3QL52;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 2 4898000.0 1341700.0 1124400.0 2431900.0 True False 1837762.7480791684 1074720.2901064272 1857535.3065526702 1.0 0.584798168985483 1.0107590375820645 20.80951909859384 -10.954485637427288 11.26651151392532 1.0620924813266206 0.7977786032838372 0.23106868288549232 0.17389779640905662 0.09891800911536028 0.00039960779009016686 0.06140881438616102 0.05612527245287038 1.1104892597675758e-11 10.954485637427288 -0.2643138780427834 K(ub)VEDMMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVEDMMK 7 1 P13639 P13639 EEF2 Elongation factor 2 1 24792500.0 8780400.0 9100800.0 6911300.0 True False 11366400.887559509 8594332.479753844 5653514.315926505 1.0 0.7561173114314765 0.4973882561290144 23.438272168779466 -6.970376403600996 0.24903640726339177 1.0830879383958278 0.16284911878437375 0.999985169390564 0.0007902928682384085 0.07618081771030248 0.008592238285926587 0.005808505312363695 0.024835954862519334 1.0705910203716735e-07 6.970376403600996 -0.9202388196114542 down K(ub)VEEEEDESALKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVEEEEDESALKR 13 2 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 23418400.0 6952500.0 8926100.0 7539800.0 True False 9000148.304263765 8429354.688327482 6167633.764881088 1.0 0.9365795321766117 0.6852813483039174 23.101517343662383 -6.94509199865818 0.6103593780062598 1.0027782272974042 0.6059878527785868 0.9987576007038116 0.004790178133324327 0.08551858540392893 0.04459540846411746 0.0048674490257722665 0.021192768023524936 1.134770406416943e-07 6.94509199865818 -0.3967903745188174 K(ub)VEEPSIYESVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVEEPSIYESVR 12 1 Q9UN19;J3KNB3;Q9UN19-2 Q9UN19 DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 1 37281600.0 2999300.0 4300500.0 29981800.0 True False 4550157.378201145 3533042.175040139 24055884.088510256 1.0 0.7764659288415401 5.286824628035281 22.117485014596777 -6.895240196428629 0.9908486556425473 0.7872102846847916 5.717076866106902 0.9840464138795506 0.26215415762944116 0.11499498870636328 0.19782678657320435 0.20007077729482634 0.5091791381034736 1.2727989359485323e-07 6.895240196428629 4.929866581422111 up K(ub)VEEPSIYESVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVEEPSIYESVR 12 1 Q9UN19;J3KNB3;Q9UN19-2 Q9UN19 DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 1 51486100.0 2999300.0 4012900.0 44473900.0 True False 3882652.9750418253 3789578.5873773973 36380106.540749766 1.0 0.9760281466660241 9.369909382735361 21.888611336689227 -6.906255535004529 0.9208598389597797 0.7083416599830014 10.372081763879237 0.9894300754439775 0.4062311769438379 0.10694641426179405 0.15258511461344906 0.3265482795512692 0.8796621926428672 1.2409219453254516e-07 6.906255535004529 9.663740103896236 up K(ub)VEFPTDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVEFPTDPK 9 1 Q96QW7;A0A0J9YWL0;Q9Y4K1-2;Q9Y4K1 Q96QW7 AIM1 Absent in melanoma 1 protein 1 8350300.0 1362700.0 3630700.0 3356900.0 True False 1786512.896405571 3089013.712357754 3009560.1896585636 1.0 1.729074398831819 1.6846003159080127 20.76871489775237 -10.220744755716904 4.684908505295996 0.9998420302495634 1.7068373573731768 0.9970396113225872 0.018156468334977555 2.9964699717816725e-05 4.984103207906124e-06 0.017583801427451203 0.0058599749556647205 6.015271641711328e-11 10.220744755716904 0.7069953271236133 K(ub)VEFPTDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVEFPTDPK 9 1 Q96QW7;A0A0J9YWL0;Q9Y4K1-2;Q9Y4K1 Q96QW7 AIM1 Absent in melanoma 1 protein 1 7171500.0 1362700.0 2460800.0 3348000.0 True False 1866527.0155828276 2352073.719222608 2557271.3542244076 1.0 1.2601337669297903 1.370069296010641 20.831924959275263 -13.128957486471851 0.12661064131578753 3.459254043816251e-17 1.5381138762503819 0.9996818107789811 0.002767940071296911 8.805153796386337 0.10222899139458928 2.3288245848874736 0.14138279879381951 7.430918763553039e-14 13.128957486471851 1.5381138762503819 K(ub)VEKVTISNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVEKVTISNR 10 2 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 17546300.0 4594200.0 6257400.0 6694700.0 True False 4448359.635737939 8756012.451909916 4941157.233305026 1.0 1.9683688300659128 1.1107818697049519 22.08484199940934 -10.299468395184151 3.9486883074323336 0.999076592071616 1.5395753499412559 0.3454730283430745 0.35010841067553666 47175587.032862596 41019395.538980536 335347.16932048963 0.11985141938863658 5.018010951676211e-11 10.299468395184151 0.5404987578696399 K(ub)VEKVTISNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVEKVTISNR 10 2 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 9446700.0 3008300.0 1749500.0 4688900.0 True False 3894303.652458352 1652138.7870658997 3835568.3121768446 1.0 0.42424498305954034 0.9849176269948982 21.89293394973989 -10.92521873264106 10.737921348515947 1.0464988923886742 0.7045813050272193 0.2701611657502514 0.228893648396464 0.1271438053962256 0.000885456416593174 0.11059004947098627 0.07387510735768009 1.187903788388465e-11 10.92521873264106 -0.34191758736145494 K(ub)VENEDMNK(ub)DQILLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVENEDMNKDQILLEK 16 2 Q15019;Q15019-2;Q15019-3;B5MCX3 Q15019 SEPT2 Septin-2 2 26683300.0 7203500.0 7978800.0 11501000.0 True False 6974828.835496539 11164776.44889234 8488543.07739571 1.0 1.6007240768507716 1.2170252887347606 22.733726382508255 -10.340993609579328 6.076552659117455 0.9999595348246604 1.4088746827927494 0.6022343909700989 0.15664437430141848 8.58854304656769e-05 9.314268275835211e-06 0.15168522468224524 0.050556754412206126 4.56043626350109e-11 10.340993609579328 0.40891514796808903 K(ub)VENEDMNK(ub)DQILLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVENEDMNKDQILLEK 16 2 Q15019;Q15019-2;Q15019-3;B5MCX3 Q15019 SEPT2 Septin-2 2 20292400.0 4263300.0 7102800.0 8926300.0 True False 5839557.221350464 6788974.810181369 6818091.782919144 1.0 1.162583831760337 1.1675699928054448 22.477427551652195 -12.495913147343103 0.5190349258064247 0.000551183579483466 1.1672406631167294 0.9999331680435086 0.0006363599363133382 10.833053489647918 0.25811796495325157 12.058951079301233 0.000981185348030253 3.1921761806449847e-13 12.495913147343103 1.166689479537246 K(ub)VENEDMNK(ub)DQILLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVENEDMNKDQILLEK 16 2 Q15019;Q15019-2;Q15019-3;B5MCX3 Q15019 SEPT2 Septin-2 2 26151200.0 7203500.0 13346000.0 5601700.0 True False 5990029.419158421 13274102.44902641 6772989.570665578 1.0 2.216032930751678 1.1307105686330936 22.51413165794253 -6.618882244933888 2.121126087531658 1.8075085499485888 1.1348452707234193 0.07897929426811234 0.5230865024345677 0.5883889111269409 5.0289282803974205 0.20275716900406937 0.5799814401756105 2.405014809874127e-07 6.618882244933888 -0.6726632792251694 K(ub)VESLWPIFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVESLWPIFR 10 1 P41223-2;P41223 P41223-2 BUD31 Protein BUD31 homolog 1 3404730.0 1284300.0 1247900.0 872530.0 True False 1243530.5994902789 1746192.9777125316 643988.2176610806 1.0 1.404221961589279 0.5178708251530363 20.246010577634706 -6.782714518674886 1.5253544867669542 1.2280723586185969 0.5102494980535062 0.7768666213274473 0.1711476517873934 0.24637478731317805 1.1324189211889126 0.088358703506825 0.20801617261040528 1.6492461590701078e-07 6.782714518674886 -0.7178228605650907 K(ub)VFHMLDKDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVFHMLDKDK 10 2 B8ZZ19;P20472;H0Y3U0;B1AH72 B8ZZ19 PVALB Parvalbumin alpha 1 14580630.0 6066700.0 0.0 8513930.0 True False 9203627.43517916 0.0 6831148.0037119165 1.0 0.0 0.742223438728204 23.1337711534622 -10.721516960906179 9.328471898223093 1.0015876409661657 0.37111172068980447 0.48907390689397123 0.30301145000299906 0.010018757485053025 0.0002990898634582768 0.2937883855546706 0.09779652496431472 1.898816684399933e-11 10.721516960906179 -0.6304759202763612 K(ub)VFHMLDKDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVFHMLDKDK 10 2 B8ZZ19;P20472;H0Y3U0;B1AH72 B8ZZ19 PVALB Parvalbumin alpha 1 9600400.0 2698000.0 5347400.0 1555000.0 True False 2243506.54166578 5318592.494824211 1880143.310492346 1.0 2.370660569090747 0.8380378107105315 21.097323959986536 -6.670955707724917 1.9342982735279908 1.8742008611287313 0.8442589303257635 0.2830960146894682 0.5821053456518288 0.4589637164224426 3.3116382506462285 0.24221103907773228 0.6462480196534334 2.1332624665207945e-07 6.670955707724917 -1.0299419308029678 K(ub)VFHMLDKDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVFHMLDKDK 10 2 B8ZZ19;P20472;H0Y3U0;B1AH72 B8ZZ19 PVALB Parvalbumin alpha 1 25413000.0 6066700.0 12599000.0 6747300.0 True False 7853462.742535331 11897854.57458891 5519360.633144411 1.0 1.5149819849718837 0.7027932536371335 22.904897475554648 -6.735383940444364 1.703795692305945 1.308039484788326 0.7027960247056396 0.5839901929912734 0.2164092033252482 0.3262163056415145 1.8575533868196905 0.10056316256823707 0.24801547301403226 1.8391453758958234e-07 6.735383940444364 -0.6052434600826865 K(ub)VFSDVMEDLYNYINPHNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVFSDVMEDLYNYINPHNGK 20 1 P23921 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 40883100.0 12982400.0 23391000.0 4509700.0 True False 16805972.721362647 22089270.287658487 3688980.8734295713 1.0 1.3143702333623366 0.21950415692037756 24.002470711747243 -6.829945890801104 1.328264570351807 1.1679819383893846 0.19009808223752353 0.9057439032005012 0.14131183659611601 0.18087978961495696 0.6241607447922277 0.08353483723659484 0.19222642771747067 1.4792926832933495e-07 6.829945890801104 -0.977883856151861 down K(ub)VGFEVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVGFEVEK 8 1 Q9UBB4;Q9UBB4-2;B1AHE3 Q9UBB4 ATXN10 Ataxin-10 1 3159450.0 747080.0 953670.0 1458700.0 True False 723364.3543309174 1334475.4043233504 1076622.709938016 1.0 1.8448177551652873 1.4883546631681186 19.464362981613434 -10.148966212153924 4.946074360603569 0.9999588316502203 1.6665862091685435 0.8234006969340544 0.1455254479277022 6.60705622677734e-05 1.136840467268348e-05 0.14091308074201161 0.046968136355200314 7.096329748288917e-11 10.148966212153924 0.6666273775183232 K(ub)VGFEVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVGFEVEK 8 1 Q9UBB4;Q9UBB4-2;B1AHE3 Q9UBB4 ATXN10 Ataxin-10 1 2209930.0 543740.0 1239200.0 426990.0 True False 744775.372020993 1184448.0465135954 326143.7561350891 1.0 1.59034266036419 0.4379088895623365 19.506445841572734 -6.767466077331148 1.5840983431412854 1.33970870763727 0.4320348328261903 0.7207504694866896 0.24864519563691528 0.27057067994824674 1.3395491197960523 0.12374903738666818 0.2952707172270588 1.7081811405901676e-07 6.767466077331148 -0.9076738748110798 down K(ub)VGWIFTDLVSEDTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVGWIFTDLVSEDTR 15 1 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 7409000.0 2468900.0 1794200.0 3145900.0 True False 2390526.1209075325 2510633.416629396 2321894.4150229697 1.0 1.050243038413764 0.9712901250966011 21.188896739200484 -6.7347833900183165 1.7058842120052664 1.0300736571163642 0.9712952477793718 0.5812774399589323 0.02111417572483137 0.32733057245467484 1.8681989000731185 0.009800311445238486 0.024187341770809823 1.8416903392753072e-07 6.7347833900183165 -0.05877840933699241 K(ub)VGWIFTDLVSEDTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVGWIFTDLVSEDTR 15 1 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 6268700.0 2468900.0 2299500.0 1500300.0 True False 2052999.7408149135 2287112.1370849893 1814005.7933965693 1.0 1.114034303860724 0.8835879310323349 20.96930201463476 -6.7721582498028114 1.5661494728681464 1.0652279254891213 0.8821839609940402 0.7387311100359167 0.04808900655150649 0.2629710732956477 1.2732564174860248 0.024197981801653844 0.05748896014338866 1.689825074839474e-07 6.7721582498028114 -0.1830439644950811 K(ub)VGYTPDWIFLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVGYTPDWIFLLR 13 1 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 1 901980.0 0.0 901980.0 0.0 True False 0.0 1262145.31776356 0.0 0.0 K(ub)VIDDTNITR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVIDDTNITR 10 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 22360900.0 1931100.0 2861100.0 17568700.0 True False 1869798.2875306972 4003552.150439397 12966930.420297535 1.0 2.141167941557262 6.9349354455886205 20.834451210947496 -6.943750873793962 0.6236921224702335 0.9476415811244883 8.384040869988313 0.9986150770643419 0.09569112743162622 0.08609635298870061 0.04712468811491895 0.09604621585136541 0.40627020648652307 1.1382800550493866e-07 6.943750873793962 7.436399288863825 K(ub)VIDDTNITR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVIDDTNITR 10 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 12972000.0 1931100.0 5341100.0 5699800.0 True False 1605795.2122352796 5312326.43417466 6891601.827102427 1.0 3.308221617362938 4.291706548003256 20.614856486381772 -9.138244161560245 0.3016770270358782 3.4179102910691104e-20 4.71302370774317 0.9986278218152201 0.051105604672561866 0.5679707024687328 0.10958739567439596 0.9657296846286751 0.3362542054738027 7.273707597094043e-10 9.138244161560245 4.71302370774317 K(ub)VIDQQNGLYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVIDQQNGLYR 11 1 P27694 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 11050590.0 2536800.0 4841490.0 3672300.0 True False 3325769.366406145 4119158.563980207 3292325.6231889976 1.0 1.2385580929297586 0.9899440581914773 21.665256694209436 -6.655587554521178 1.988886702456331 1.1541160234322796 0.9909940177471802 0.21686234586726183 0.1016816572253229 0.4950070507284048 3.759418630419973 0.04137578374195748 0.11264835745836019 2.2101026508539193e-07 6.655587554521178 -0.16312200568509938 K(ub)VIDQQNGLYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVIDQQNGLYR 11 1 P27694 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 18411100.0 5096700.0 4617200.0 8697200.0 True False 4934908.048292536 6460872.03837991 6419142.409592736 1.0 1.309218322845013 1.3007623134566286 22.234591772646525 -10.072014302428661 4.441434126174848 0.999977095359052 1.3049903181748375 0.9994238029987174 0.0034521514560729126 1198168.6800611282 0.0017205801635246313 282.45862917200066 0.0011817632534940096 8.471995132331964e-11 10.072014302428661 0.30501322281578547 K(ub)VIDQQNGLYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVIDQQNGLYR 11 1 P27694 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 38112400.0 8876400.0 16611000.0 12625000.0 True False 13466147.751763618 13646637.267664619 10129663.21626593 1.0 1.0134032032937825 0.7522317000375465 23.68283386361735 -6.894804803569908 0.9935047210820207 1.0124597771181736 0.7275326725085622 0.983800324368525 0.015283915879935696 0.11533196139200624 0.19975827645489722 0.011641125608812943 0.02957184883665794 1.2740755937644e-07 6.894804803569908 -0.28492710460961135 K(ub)VIDQQNGLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVIDQQNGLYR 11 1 P27694 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 11021340.0 2536800.0 4758340.0 3726200.0 True False 3474723.5144422976 4548100.805073837 2846148.3034979017 1.0 1.3089101294448802 0.8191006541004504 21.728466755732327 -6.736251002776714 1.700434789127496 1.1845951699925332 0.8190429765963079 0.5879782464188588 0.12980759792247767 0.3246482712385318 1.8416603973233021 0.06042790890759188 0.14889856450379593 1.8354772130398333e-07 6.736251002776714 -0.36555219339622536 K(ub)VIDQQNGLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVIDQQNGLYR 11 1 P27694 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 15820400.0 5096700.0 7765400.0 2958300.0 True False 4238131.872093398 7723566.248888777 3576866.85236624 1.0 1.8223987553916698 0.8439725238184884 22.0149970480808 -6.683809441626376 1.8884806316084757 1.5185509093852911 0.8475883620435564 0.3416185341897977 0.34826520919030435 0.43009644023828747 2.9688168013117022 0.14780566769453757 0.38791709338183494 2.0710498782397375e-07 6.683809441626376 -0.6709625473417348 K(ub)VIDQQNGLYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVIDQQNGLYR 11 1 P27694 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 37312400.0 8876400.0 18836000.0 9600000.0 True False 11490674.780002413 17787760.041825254 7852898.504318212 1.0 1.54801701226301 0.6834149129331256 23.4539601857098 -6.735433123490563 1.7033376549333163 1.3277877299719543 0.6833923060865686 0.5842520252138361 0.23029310875708517 0.3261685730773132 1.8562518320758192 0.10703558841765135 0.2639919444332616 1.8389371078794557e-07 6.735433123490563 -0.6443954238853856 K(ub)VKTDTVLILCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVKTDTVLILCR 12 2 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 4419300.0 1611800.0 1746400.0 1061100.0 True False 2207726.017257212 1669238.2734274864 810490.034040476 1.0 0.7560894152532928 0.36711531580689316 21.07412971151708 -6.964219582497221 0.3712056889683801 1.0295065078798484 0.08013300310591873 0.9998961384797063 0.0026561043328441215 0.07822683405536886 0.01580007640259646 0.005117766689429484 0.03301406750919643 1.0858764576416319e-07 6.964219582497221 -0.9493735047739297 down K(ub)VLEALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVLEALK 7 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 4315500.0 1065000.0 2019600.0 1230900.0 True False 1396225.3134746694 1718283.5523391403 1103538.2756265376 1.0 1.2306635152337924 0.7903726318213312 20.41310034210616 -6.764353694013577 1.59615138651252 1.1332537203980064 0.7884116654169279 0.7084795152229426 0.09708760150756017 0.27565324534386293 1.3850339891902361 0.04797188425555127 0.11479074139254695 1.7204668379024137e-07 6.764353694013577 -0.34484205498107856 K(ub)VLEALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVLEALK 7 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 10628500.0 2899700.0 3935200.0 3793600.0 True False 2807650.610715531 5506545.881796895 2799942.354439473 1.0 1.961264646242272 0.9972545528825278 21.420931984471647 -6.646853097279643 2.020230137334039 1.6253147291584906 1.0013285339634916 0.18131385205320705 0.41059769404311786 0.5162065907665084 4.034746845365114 0.16505722346561805 0.4546079977513116 2.2550018510992996e-07 6.646853097279643 -0.623986195194999 K(ub)VLEALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVLEALK 7 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 4511300.0 1065000.0 1668600.0 1777700.0 True False 1458759.280542827 1594875.7346776829 1357843.8728807436 1.0 1.093309743389742 0.9308210689672314 20.47631040362905 -6.7509948890087195 1.64647262884297 1.0548013701684653 0.9304792412411973 0.6531503189274619 0.039211064953544685 0.29829532611187537 1.5913537311226924 0.01881188417132527 0.04561700322695044 1.7742103605483295e-07 6.7509948890087195 -0.12432212892726802 K(ub)VLEALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVLEALK 7 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 12303500.0 2899700.0 8113300.0 1290500.0 True False 2411229.028490829 8069592.042536038 1560337.5834021703 1.0 3.3466717376021053 0.647112972249996 21.201337259905923 -6.676899985641606 1.9130915851098884 2.4888813247472923 0.6576643000385161 0.3099464250698628 0.9952561090368939 0.4454262879447852 3.149173845214893 0.4178769192499707 1.1064419599796051 2.1042629779982158e-07 6.676899985641606 -1.8312170247087762 K(ub)VLESVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVLESVFR 8 1 Q9BYE7 Q9BYE7 PCGF6 Polycomb group RING finger protein 6 1 7445300.0 3181000.0 2927600.0 1336700.0 True False 3080020.896191368 4096605.9472323116 986578.1698595653 1.0 1.330057842236724 0.32031541444395034 21.554508708143505 -6.818657361138256 1.3775817208768244 1.1781489195841042 0.29888492981348813 0.8812787103194734 0.14484662969071474 0.19523830442358253 0.7283783533409746 0.0826315442450853 0.19053249533601604 1.5182477244056486e-07 6.818657361138256 -0.879263989770616 down K(ub)VLGSSTSATNSTSVSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVLGSSTSATNSTSVSSR 18 1 Q15004;H0YMA4;A0A0U1RQM0;A0A0U1RQC1;Q15004-2 Q15004 KIAA0101 PCNA-associated factor 1 320986100.0 118245500.0 143345900.0 59394700.0 True False 155020995.59105086 121959250.4779419 53249106.19819279 1.0 0.7867273075685396 0.3434960922239541 27.207888382235744 -6.959287375477618 0.4453633647008422 1.0149904067781108 0.09779724943090036 0.9997428488699789 0.004384899464787515 0.07995667030392754 0.022079359118190797 0.005884974981604104 0.03668937261053799 1.0982788606848855e-07 6.959287375477618 -0.9171931573472104 down K(ub)VLGSSTSATNSTSVSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVLGSSTSATNSTSVSSR 18 1 Q15004;H0YMA4;A0A0U1RQM0;A0A0U1RQC1;Q15004-2 Q15004 KIAA0101 PCNA-associated factor 1 600173500.0 179189700.0 265549600.0 155434200.0 True False 173501421.05698285 371584940.1028699 114721320.09395199 1.0 2.1416824014417193 0.6612125675689665 27.37037223829129 -6.700826204038851 1.8287461035602748 1.7083971760407957 0.6656644790176114 0.42116391262414166 0.4818485322137242 0.39378385923424797 2.561079347994504 0.21019725831466307 0.5398562060903235 1.991470126041295e-07 6.700826204038851 -1.0427326970231843 K(ub)VLGSSTSATNSTSVSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVLGSSTSATNSTSVSSR 18 1 Q15004;H0YMA4;A0A0U1RQM0;A0A0U1RQC1;Q15004-2 Q15004 KIAA0101 PCNA-associated factor 1 234934100.0 126511800.0 64709200.0 43713100.0 True False 191927649.8514678 53161337.68471277 35073186.62486766 1.0 0.2769863421234729 0.18274170840944853 27.515987325921817 -13.999999999999998 0.2872208645920042 7.133674779327395 0.15633294805568565 0.999621246961435 0.007105004852182661 15.80261941492995 0.16989656409313808 57.179089942901975 0.03604649474876467 1.0000000000000041e-14 13.999999999999998 -6.977341831271709 K(ub)VLGSSTSATNSTSVSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVLGSSTSATNSTSVSSR 18 1 Q15004;H0YMA4;A0A0U1RQM0;A0A0U1RQC1;Q15004-2 Q15004 KIAA0101 PCNA-associated factor 1 280523500.0 118245500.0 108422500.0 53855500.0 True False 161964056.81448546 103632035.44473884 41135940.08883888 1.0 0.6398458860748317 0.2539819074546658 27.271098443758635 -7.442070300189086 0.3344745503117673 1.0635734899641016 3.82054365914058e-15 0.999599375567947 0.006097168627891666 0.1184129705792269 0.032946001967095594 0.018197538237446367 0.061235358447350466 3.613513651765025e-08 7.442070300189086 -1.0635734899640978 down K(ub)VLGSSTSATNSTSVSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVLGSSTSATNSTSVSSR 18 1 Q15004;H0YMA4;A0A0U1RQM0;A0A0U1RQC1;Q15004-2 Q15004 KIAA0101 PCNA-associated factor 1 766810150.0 179189700.0 562450000.0 25170450.0 True False 149004174.999677 559419970.2124157 30433474.719988465 1.0 3.754391245840114 0.20424578519396813 27.150777513725565 -6.699607285353958 1.8322715549538504 2.7110525464527253 0.21489503222224188 0.4156620661762017 1.1627514925084736 0.39636761450488395 2.5867864126012186 0.506319125587498 1.3027500357241784 1.997067364647741e-07 6.699607285353958 -2.4961575142304833 K(ub)VLGSSTSATNSTSVSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVLGSSTSATNSTSVSSR 18 1 Q15004;H0YMA4;A0A0U1RQM0;A0A0U1RQC1;Q15004-2 Q15004 KIAA0101 PCNA-associated factor 1 234377000.0 126511800.0 88933200.0 18932000.0 True False 163772019.0204035 83983989.24143423 15486570.258724218 1.0 0.5128103673862084 0.09456175939795203 27.287113648014266 -7.967477731718014 0.43589905320155026 1.0452717460419487 3.386828320723752e-14 0.9965418223461933 0.021758355667844974 0.10138010006771393 0.09714337657590424 0.04245390211558954 0.0801545743856606 1.0777605140320843e-08 7.967477731718014 -1.0452717460419148 down K(ub)VLIIGGGDGGVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVLIIGGGDGGVLR 14 1 P19623;K7ESL0 P19623 SRM Spermidine synthase 1 10330170.0 892870.0 2558400.0 6878900.0 True False 864526.3305823277 3579982.4618797507 5077109.72742347 1.0 4.140975624731229 5.872706877537935 19.72155037864221 -8.58387853137202 0.30665433646735246 2.2519495868388647e-18 6.724542418656136 0.9986110287863353 0.07516449347700832 0.2132252230352349 0.09004845908289323 0.763484747478037 0.5522091184820749 2.606882571858011e-09 8.58387853137202 6.724542418656136 K(ub)VLIIGGGDGGVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVLIIGGGDGGVLR 14 1 P19623;K7ESL0 P19623 SRM Spermidine synthase 1 7068770.0 892870.0 3380500.0 2795400.0 True False 742460.9658477105 3362288.5755232875 3379905.2155307396 1.0 4.528572854580131 4.552300216445328 19.501955654076486 -10.424366893736323 0.9550328763145497 2.686809684514322e-17 4.546155450911223 0.9999928573385971 0.004460541036984111 1.8844743812626035 0.5509285522317036 4.873502497686499 0.003170453802477629 3.7638569247739275e-11 10.424366893736323 4.546155450911223 K(ub)VLSGQDTEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVLSGQDTEDR 11 1 Q5TIH2;O95562 Q5TIH2 SFT2D2 Vesicle transport protein SFT2B 1 6632160.0 4287530.0 719230.0 1625400.0 True False 5620993.350499582 611923.6875365825 1457219.1999377492 1.0 0.1088639764148086 0.25924585016778834 22.422393677564358 -10.292745620518378 6.023538088795314 1.000044821587907 0.1840549132912989 0.9751569503046587 0.06139314287641161 3.695593831991351e-05 4.33927436670636e-06 0.059446896718165027 0.019814551660972138 5.096292890209323e-11 10.292745620518378 -0.8159899082966081 K(ub)VPDKLLDSSTVTHLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVPDKLLDSSTVTHLFK 17 2 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 62260600.0 39790000.0 3432600.0 19038000.0 True False 52165075.32690817 2920469.4601700013 17068130.38539122 1.0 0.05598514795326181 0.32719458906995985 25.63658090557406 -10.358326832216937 6.900582825367497 1.000030179467606 0.1915898685116114 0.9221582100573349 0.11072079069355172 5.1409756039739015e-05 4.780463395447555e-06 0.10720892306040762 0.03573498153625357 4.3820080170440466e-11 10.358326832216937 -0.8084403109559947 K(ub)VPDKLLDSSTVTHLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVPDKLLDSSTVTHLFK 17 2 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 56184300.0 7173300.0 18069000.0 30942000.0 True False 10882420.538475739 14844445.77625863 24826300.1376396 1.0 1.3640757333145517 2.281321517567169 23.3754961500699 -6.955295901351974 0.4973185713769901 0.9811956785848696 2.7035832060082865 0.9995540088642615 0.011385019010207281 0.08142631230409664 0.027681673835408052 0.013419991744694874 0.07565853365204336 1.1084193496584298e-07 6.955295901351974 1.7223875274234168 up K(ub)VPDKLLDSSTVTHLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVPDKLLDSSTVTHLFK 17 2 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 78483300.0 39790000.0 31951000.0 6742300.0 True False 54501438.2843185 30539299.172172274 5149907.602027244 1.0 0.5603393255946282 0.09449122379416193 25.699790967096952 -7.765146239594921 0.4748158458117086 1.0259330516289706 3.7766039041499826e-18 0.9960914701955984 0.02311448754710848 0.11368054292493428 0.09146641907370899 0.03160151635563608 0.07698432140678474 1.717330014776009e-08 7.765146239594921 -1.0259330516289706 down K(ub)VPDKLLDSSTVTHLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVPDKLLDSSTVTHLFK 17 2 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 43811300.0 7173300.0 14349000.0 22289000.0 True False 9285978.25688245 13550465.53621526 18232630.704453006 1.0 1.4592394211317605 1.9634582593319776 23.14662247216235 -6.969924731333635 0.2599772247267337 0.8584007953547946 2.5792558616174937 0.9999817897217933 0.0016790773528653987 0.07632713735132346 0.009117478571644608 0.010527239777995306 0.04757546167448457 1.0717050290306536e-07 6.969924731333635 1.7208550662626991 K(ub)VPGVTAIELDEDTGTFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVPGVTAIELDEDTGTFR 18 1 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 31975200.0 15129000.0 11786000.0 5060200.0 True False 12580433.828340106 11722506.478662167 6118264.424278695 1.0 0.9318046292056101 0.4863317519699521 23.58467833771675 -6.934063504921883 0.7126452401678992 1.0058608439158545 0.38463403753616077 0.997278395356583 0.011883030779157722 0.09058202461413967 0.0677408671068775 0.011100761444142225 0.03944582579650497 1.1639558169605428e-07 6.934063504921883 -0.6212268063796937 down K(ub)VQTESSTGSVGSNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVQTESSTGSVGSNR 15 1 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 1 7434220.0 2339200.0 4583500.0 511520.0 True False 1945148.4441306859 4558807.77574648 618476.4669987425 1.0 2.343681167112094 0.3179584925073152 20.891448828103343 -6.727867080605792 1.7308201725693204 1.8105549356425037 0.31959745193838596 0.5493420025210768 0.5649571899549518 0.3402978644903179 1.9961486594715718 0.258760439144943 0.6436986504931725 1.871254765627635e-07 6.727867080605792 -1.4909574837041177 K(ub)VSK(ub)AAILAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVSKAAILAR 10 2 O00767 O00767 SCD Acyl-CoA desaturase 2 4939210.0 858090.0 766620.0 3314500.0 True False 1124964.2997553812 652243.2842613545 2971547.3349290476 1.0 0.5797902070342873 2.6414592317064622 20.101447788203732 -6.853621146388088 1.2175041269385936 0.7748665384462602 2.7298097791650586 0.9454087334355158 0.20783771422230896 0.15351882044613122 0.43609425702468607 0.13344451414293854 0.30959712362442243 1.400808775012476e-07 6.853621146388088 1.9549432407187983 up K(ub)VVDFLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVVDFLLK 8 1 A0A0G2JQ62;Q8NF37 A0A0G2JQ62 LPCAT1 Lysophosphatidylcholine acyltransferase 1 1 19190500.0 6227200.0 6747700.0 6215600.0 True False 8163919.504290589 5740969.462328598 5572469.336245283 1.0 0.7032124042025895 0.6825727928008897 22.96083052688671 -13.999999999999998 0.3785692650981173 5.36362905308379 0.6807138848540808 0.9998052018867577 0.0020239928949917145 23.85619380424705 0.20052238713432172 84.78859209927914 0.005618555935126834 1.0000000000000041e-14 13.999999999999998 -4.68291516822971 K(ub)VWLDPNETNEIANANSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVWLDPNETNEIANANSR 18 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 13579900.0 1684100.0 3172400.0 8723400.0 True False 2207871.4088475993 2699090.285918349 7820786.248761519 1.0 1.2224852747774573 3.5422290525713116 21.074224718242682 -6.925523626837131 0.7826661629310984 0.9582655376383563 3.968362286748454 0.9955829150720196 0.07640187261028852 0.09502950673021578 0.08956247930383053 0.06783411873228802 0.21529323686578464 1.1870701193450856e-07 6.925523626837131 3.0100967491100974 up K(ub)VWLDPNETNEIANANSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVWLDPNETNEIANANSR 18 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 21950100.0 4194700.0 5119400.0 12636000.0 True False 4061541.544562689 7163603.11731831 9326252.528125588 1.0 1.7637645802019302 2.2962346748886344 21.95359597077173 -7.8716270454272985 0.13204094950047088 2.2390488780054876e-18 3.5912043529543367 0.9999760284345689 0.0026046393731084068 0.12563796823219317 0.019708510817675735 0.2170173213079153 0.2783462728945934 1.3439185687567143e-08 7.8716270454272985 3.5912043529543367 K(ub)VWLDPNETNEIANANSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVWLDPNETNEIANANSR 18 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 11546500.0 1684100.0 3189800.0 6672600.0 True False 2306757.2810912468 3048864.0887419856 5096669.306510683 1.0 1.32170996651181 2.209451921226678 21.137434779765574 -6.953313056565429 0.5212042766034897 0.9850541077997563 2.585806260773866 0.9994362882976846 0.012143486181100204 0.08218203086471447 0.03066295884469728 0.013730794135262885 0.07333680917821701 1.113491595639499e-07 6.953313056565429 1.6007521529741096 up K(ub)VWLDPNETNEIANANSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVWLDPNETNEIANANSR 18 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 16651300.0 4194700.0 6354900.0 6101700.0 True False 3488078.9067180995 6320664.892351115 7377537.258926781 1.0 1.8120762349089656 2.115071779115294 21.734001246206006 -10.424144774474565 0.21550306214733733 2.0054096517433957e-18 2.335076487683845 0.9993040071560235 0.01241982384125619 2.087213341068348 0.10745337650205933 1.3045145118201198 0.16770897483363997 3.765782436114024e-11 10.424144774474565 2.335076487683845 K(ub)VYENYPTYDLTER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVYENYPTYDLTER 14 1 H0Y993;P35659;A0A494C028;P35659-2;B4DFG0;A0A494C198 H0Y993 DEK Protein DEK 1 7107000.0 1110400.0 2804100.0 3192500.0 True False 1455745.1531288964 2385739.210296191 2862170.724622411 1.0 1.6388440003859315 1.9661207310020048 20.47332638468386 -9.989610788305058 0.15407994221899524 3.561041265023458e-16 2.4342674614909003 0.9997090196384749 0.006843650399966398 1.5552113471953413 0.0714860281415024 0.9104625575862714 0.27755189393287844 1.0242104714030666e-10 9.989610788305058 2.4342674614909 K(ub)VYENYPTYDLTER ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVYENYPTYDLTER 14 1 H0Y993;P35659;A0A494C028;P35659-2;B4DFG0;A0A494C198 H0Y993 DEK Protein DEK 1 10298600.0 1636700.0 2401900.0 6260000.0 True False 1584743.8543842842 3360991.195743034 4620318.204025495 1.0 2.1208419180454054 2.915498420292416 20.595818242576737 -7.90852080764801 0.1673963050855504 5.0452721382757367e-20 4.301408850045901 0.9999315903203442 0.006499106199048936 0.11984582777693611 0.02672854603014124 0.25886830876880673 0.34641125017343294 1.234466168775941e-08 7.90852080764801 4.301408850045901 K(ub)VYENYPTYDLTER ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVYENYPTYDLTER 14 1 H0Y993;P35659;A0A494C028;P35659-2;B4DFG0;A0A494C198 H0Y993 DEK Protein DEK 1 32642500.0 6312500.0 12847000.0 13483000.0 True False 9576524.005566215 10554352.475930845 10818079.140191155 1.0 1.102106826004538 1.1296456975310982 23.191070664749766 -13.999999999999494 0.1839114521676415 0.46366252556828474 1.1506600443627444 0.9994939287481149 0.0012545804068540413 12.257925236810438 0.13597765416413032 2.351601173510256 0.01989803795352352 1.0000000000011658e-14 13.999999999999494 0.6869975187944597 K(ub)VYENYPTYDLTER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVYENYPTYDLTER 14 1 H0Y993;P35659;A0A494C028;P35659-2;B4DFG0;A0A494C198 H0Y993 DEK Protein DEK 1 7891300.0 1110400.0 2084800.0 4696100.0 True False 1520944.8874316968 1992686.6424883313 3586977.8992154193 1.0 1.3101636087900783 2.3583878211869167 20.53653644620675 -6.948746053115005 0.572443166255503 0.9870823608997721 2.7326473895539736 0.9990991808013748 0.017444081660881204 0.08399317951045496 0.03807639158266278 0.01842985226811799 0.08739076796393641 1.1252627613791212e-07 6.948746053115005 1.7455650286542015 up K(ub)VYENYPTYDLTER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVYENYPTYDLTER 14 1 H0Y993;P35659;A0A494C028;P35659-2;B4DFG0;A0A494C198 H0Y993 DEK Protein DEK 1 7150600.0 1636700.0 3358000.0 2155900.0 True False 1360988.5681039207 3339909.7874891865 2606688.722244664 1.0 2.454032212880543 1.9152906815934592 20.376223518011013 -10.559242604654042 7.147718901815493 0.9991621156017509 2.184661447236998 0.8657200578277295 0.21994030914983584 0.002938208621648611 0.0001811815008633561 0.21306624128231533 0.07098542954141877 2.7590361787706206e-11 10.559242604654042 1.185499331635247 K(ub)VYNITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVYNITK 7 1 O95864;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 3008660.0 389790.0 555570.0 2063300.0 True False 511018.46473172976 472681.121594899 1849809.5085711577 1.0 0.9249785559960992 3.61984866739063 18.963015895728116 -6.900498091608852 0.9581303206142149 0.8894833741716586 3.9055827631278652 0.9868120214960222 0.14390070323019521 0.11103900771215397 0.17536644960563597 0.11253819610821653 0.29353825096817165 1.2574823800261017e-07 6.900498091608852 3.0160993889562064 up K(ub)YADVIIPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYADVIIPR 9 1 Q9BZX2;A0A2R8Y653;Q9BZX2-2;Q9HA47-3;Q9HA47;Q9HA47-4 Q9BZX2 UCK2;UCK1 Uridine-cytidine kinase 2;Uridine-cytidine kinase 1 1 7930570.0 3808000.0 3275500.0 847070.0 True False 4992324.876724455 2786808.167799001 759423.3220691951 1.0 0.5582185127397942 0.1521181695545954 22.251280390300902 -7.818111460667735 0.3876428267591781 1.056507695991429 8.352585482224908e-25 0.9981865117801765 0.014745013947225551 0.1125219385784944 0.0698227652007435 0.03559484536610062 0.07971499572065695 1.5201573348223012e-08 7.818111460667735 -1.056507695991429 down K(ub)YADVIIPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYADVIIPR 9 1 Q9BZX2;A0A2R8Y653;Q9BZX2-2;Q9HA47-3;Q9HA47;Q9HA47-4 Q9BZX2 UCK2;UCK1 Uridine-cytidine kinase 2;Uridine-cytidine kinase 1 1 8866700.0 3419800.0 3766000.0 1680900.0 True False 3311240.320903882 5269783.439430551 1240621.8640809024 1.0 1.5914832294600827 0.3746698348195534 21.658940290779206 -6.774530176708067 1.557101411544486 1.3372959187038653 0.3666217187577335 0.747572236236012 0.24961628412967238 0.25917567607648434 1.2407103495824119 0.12631311627814215 0.29944725859910754 1.68062114463557e-07 6.774530176708067 -0.9706741999461319 down K(ub)YADVIIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYADVIIPR 9 1 Q9BZX2;A0A2R8Y653;Q9BZX2-2;Q9HA47-3;Q9HA47;Q9HA47-4 Q9BZX2 UCK2;UCK1 Uridine-cytidine kinase 2;Uridine-cytidine kinase 1 1 9521200.0 3808000.0 3974800.0 1738400.0 True False 5215920.507330599 3799180.1930941246 1327825.7234718346 1.0 0.7283815364430212 0.25457169479589875 22.314490451823794 -7.082944646622163 0.4262641399998522 1.0210314872589268 9.080911979088608e-12 0.9997764634970625 0.004605377331687522 0.07499492712467334 0.021387451001544336 0.0067633666885618254 0.037606956001184036 8.261432396664037e-08 7.082944646622163 -1.0210314872498458 down K(ub)YADVIIPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYADVIIPR 9 1 Q9BZX2;A0A2R8Y653;Q9BZX2-2;Q9HA47-3;Q9HA47;Q9HA47-4 Q9BZX2 UCK2;UCK1 Uridine-cytidine kinase 2;Uridine-cytidine kinase 1 1 18206800.0 9597500.0 5482900.0 3126400.0 True False 12424152.945008485 5177771.795143542 2557427.27957297 1.0 0.416750487382221 0.20584319034807433 23.566644159162646 -12.25728871588967 0.16755916828185732 2.623532083855347 8.866792880842984e-20 0.9995134590226362 0.007408760453205278 6.0282157801325 0.11379619717699417 3.519848250560362 0.1720096517424316 5.529823682392272e-13 12.25728871588967 -2.623532083855347 K(ub)YAEAVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYAEAVTR 8 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 1744970.0 505680.0 576810.0 662480.0 True False 692643.561488166 551324.6269444056 506015.86820387805 1.0 0.79597163331724 0.7305573838247877 19.401753598279587 -13.999999999999998 0.15914145404678634 2.003009278582793 0.6656388784592474 0.9995386501921326 0.002464692552819567 12.004090791334853 0.12603698688228848 3.7167254365957656 0.059104404025242176 1.0000000000000041e-14 13.999999999999998 -1.3373704001235454 K(ub)YAVLYQPLFDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYAVLYQPLFDK 12 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 18866700.0 9029700.0 8181300.0 1655700.0 True False 7508595.633535766 8137225.713039091 2001899.214908151 1.0 1.0837213921463107 0.26661433277443186 22.840111668542487 -6.881639186725414 1.0706479813313812 1.0531000870711325 0.20686268737689603 0.9749823917496445 0.058056049614460405 0.12618648405688768 0.26361380831295994 0.04170836167369719 0.10129208815029382 1.3132905319707898e-07 6.881639186725414 -0.8462373996942364 down K(ub)YAVLYQPLFDKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYAVLYQPLFDKR 13 2 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;H0YH88;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 69200000.0 17486000.0 34836000.0 16878000.0 True False 22635971.700590614 32897345.976694927 13806377.182904467 1.0 1.4533215720461683 0.6099308377622787 24.432113903093896 -6.760720981948674 1.6098907871948853 1.263079677166704 0.6067532861238034 0.6938572691078287 0.19068736677350798 0.2817055070134369 1.4391596247037395 0.09345126408337048 0.22440644439225604 1.7349182602327692e-07 6.760720981948674 -0.6563263910429007 K(ub)YCQVIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYCQVIR 7 1 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2 P39023 RPL3 60S ribosomal protein L3 1 2860490.0 1018100.0 737190.0 1105200.0 True False 846595.2594773654 733218.611149241 1336292.2101325677 1.0 0.8660792780742523 1.578431009591892 19.691312884723615 -6.858093730933118 1.1953965129009214 0.9276792791931904 1.611679717328626 0.9512709373844854 0.06823582533227601 0.14878176002525656 0.40508995193654423 0.04455533284224193 0.10378789517784529 1.38645656674055e-07 6.858093730933118 0.6840004381354355 K(ub)YCQVIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYCQVIR 7 1 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2 P39023 RPL3 60S ribosomal protein L3 1 6929300.0 1956000.0 1312800.0 3660500.0 True False 2532080.5585242617 1239741.5259560545 2994326.5599017525 1.0 0.4896137770113429 1.1825558036932662 21.271891874380568 -6.7093255735564306 1.7975329039169665 0.6860209514463057 1.1809048321288231 0.46201768857502234 0.21509496362168484 0.3763883605043933 2.370256445142706 0.09523942400069944 0.24215786151617302 1.952874913084619e-07 6.7093255735564306 0.49488388068251743 K(ub)YDDVTEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYDDVTEK 8 1 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7;A0A2R8Y5M6;C9JM14 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 8400780.0 712830.0 748350.0 6939600.0 True False 934527.033055539 636699.0970454529 6221556.761343669 1.0 0.6813062378342284 6.657439048072911 19.83387687183804 -6.89430640578115 0.9965381975870208 0.7112538268215928 7.217036574349887 0.9835152183219695 0.35245749323541326 0.1157193744115582 0.20198410369318281 0.2678410763096271 0.67897533575128 1.2755385664397627e-07 6.89430640578115 6.505782747528294 up K(ub)YDEVLHMVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYDEVLHMVR 10 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IU89 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 12244600.0 5435700.0 3474400.0 3334500.0 True False 7036620.803665804 3281046.5857569436 2727655.2148592845 1.0 0.46628156856877195 0.3876370904395307 22.746451339067036 -13.999999999999725 0.26966712380097746 5.112080120483151 0.36144781210247984 0.999582612913965 0.005557691946801083 14.866645093009142 0.164384092351501 33.507819341490226 0.03271694381843426 1.000000000000634e-14 13.999999999999725 -4.750632308380672 K(ub)YDIITTPAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYDIITTPAER 11 1 Q3ZCQ3 Q3ZCQ3 FAM174B Membrane protein FAM174B 1 32597400.0 13133400.0 15129100.0 4334900.0 True False 17218014.584026527 12871897.252769904 3886366.1312969998 1.0 0.7475831310255366 0.22571511438388803 24.0374154588094 -7.078417782906501 0.4796144450980363 1.012699350566329 6.788059693499408e-11 0.9996125700942288 0.006346218789745615 0.07490360514349127 0.026488917812890783 0.007848037695742204 0.040044371026828667 8.34799570773447e-08 7.078417782906501 -1.0126993504984485 down K(ub)YDIITTPAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYDIITTPAER 11 1 Q3ZCQ3 Q3ZCQ3 FAM174B Membrane protein FAM174B 1 8915160.0 5554300.0 3360860.0 0.0 True False 5377981.786770101 4702868.924653362 0.0 1.0 0.8744672464719898 0.0 22.35863343867015 -7.146811340695028 0.9409684279814835 0.9945100421261385 1.018426251155634e-20 0.9896889511460969 0.04516429447118691 0.08758480139104902 0.14684964981074405 0.03774846374814299 0.06632426613975838 7.13162763677736e-08 7.146811340695028 -0.9945100421261385 down K(ub)YDIITTPAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYDIITTPAER 11 1 Q3ZCQ3 Q3ZCQ3 FAM174B Membrane protein FAM174B 1 15301600.0 13133400.0 2168200.0 0.0 True False 17989172.896789856 2072401.7547214122 0.0 1.0 0.1152027259180565 0.0 24.10062552033229 -10.602447526071053 0.4209620293280435 1.6801386977648205 2.266039508621506e-23 0.9992308890702097 0.012389193222958915 2.3500986773817476 0.2240244650396778 1.7069276240249838 0.02852782227199343 2.497770165717748e-11 10.602447526071053 -1.6801386977648205 K(ub)YDIITTPAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYDIITTPAER 11 1 Q3ZCQ3 Q3ZCQ3 FAM174B Membrane protein FAM174B 1 12851260.0 5554300.0 6502200.0 794760.0 True False 4618646.547210609 6467171.358014348 960940.6414449489 1.0 1.4002308450990129 0.20805676113607363 22.139038714104426 -6.816165543063948 1.388314324394866 1.2166005895460572 0.1840981397524284 0.8753357609453478 0.17490891568547237 0.19852263387975225 0.7528568840383619 0.0990263477399957 0.2285133499688924 1.5269838961644304e-07 6.816165543063948 -1.0325024497936288 down K(ub)YEDICPSTHNMDVPNIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYEDICPSTHNMDVPNIK 18 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 16293200.0 7858600.0 0.0 8434600.0 True False 10173112.61616501 0.0 6899589.346304424 1.0 0.0 0.6782181232655403 23.278257825103996 -10.42646318765619 8.045716837744951 1.0000160551740103 0.33910906486842146 0.5587084051746856 0.27688138938476636 7.974196651202254e-05 5.684410714681662e-06 0.2680957403051894 0.08936308416349764 3.7457329585433694e-11 10.42646318765619 -0.6609069903055889 K(ub)YEEIDNAPEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYEEIDNAPEER 12 1 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 1 6395910.0 924370.0 664940.0 4806600.0 True False 1196615.1870567848 627935.5044707634 3931848.1198808313 1.0 0.5247597650964504 3.2858083053012828 20.190527847769367 -6.862535667354811 1.1727619094078614 0.7401796830936691 3.4261951680486393 0.9566542956940564 0.25093353631201315 0.14421792284510584 0.3754642002262111 0.16669619705331606 0.3903229643158404 1.372348249370621e-07 6.862535667354811 2.6860154849549702 up K(ub)YEMFAQTLQQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYEMFAQTLQQSR 13 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 35646100.0 12936000.0 14960000.0 7750100.0 True False 12525353.760808386 20933606.015369385 5720116.311983704 1.0 1.6712985848647464 0.4566830144056967 23.57834801507765 -6.7566609379832645 1.624899958318525 1.3915416955612558 0.45294219607382963 0.677237796208116 0.28223228444968923 0.2885662003086977 1.5008078998668632 0.1370926490070279 0.3305688951967893 1.7512133608600402e-07 6.7566609379832645 -0.9385994994874263 K(ub)YEMFAQTLQQSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYEMFAQTLQQSR 13 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 52423000.0 27184000.0 25239000.0 0.0 True False 41240115.416603886 20734903.25679294 0.0 1.0 0.5027848018205293 0.0 25.297545034520105 -7.920094769812842 0.5946549148615007 1.0101316592573932 2.432269008669175e-18 0.9889324465970791 0.042948937987306104 0.11264329494024897 0.16119724674634017 0.04473386645998684 0.07708203877453255 1.2020021104352204e-08 7.920094769812842 -1.0101316592573932 down K(ub)YEMFAQTLQQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYEMFAQTLQQSR 13 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 29369200.0 12936000.0 12583000.0 3850200.0 True False 10756857.16196756 12515212.881470056 4655259.018686582 1.0 1.1634637044098177 0.43277129635465744 23.358753290511928 -6.847969413930361 1.2447137461383357 1.0871098115099698 0.40466531367620345 0.9373081571064272 0.07839929091323837 0.1597136937190422 0.4771725240421126 0.04930828271066796 0.11397341377235093 1.4191574652122325e-07 6.847969413930361 -0.6824444978337663 down K(ub)YGGSVGSQPPPVAPEPGPVPSSPSQEPPTKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYGGSVGSQPPPVAPEPGPVPSSPSQEPPTKR 32 2 Q04323;E9PJ81;E9PRQ7;Q04323-2;A0A087WTZ5;E9PS08 Q04323 UBXN1 UBX domain-containing protein 1 1 26960200.0 10483000.0 11076000.0 5401200.0 True False 8717078.97564209 11016331.389586145 6530565.947672836 1.0 1.2637640912017427 0.7491690698135267 23.055413349585507 -6.767391621232769 1.5846155007775335 1.1517913407667595 0.7465668290239554 0.7204339317466726 0.11109075020980864 0.2706603609218677 1.3408938895306022 0.05527461917307083 0.13188442798790587 1.7084740188359837e-07 6.767391621232769 -0.40522451174280405 K(ub)YGTCPHGGYGLGLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYGTCPHGGYGLGLER 16 1 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 1 55301000.0 3695000.0 11976000.0 39630000.0 True False 5605585.1406839015 9838789.231084915 31797113.129553914 1.0 1.7551761295493493 5.672398568844956 22.418433546369396 -6.938988725629011 0.6689044746030478 0.9551683873823631 6.698050414616412 0.9980284349355797 0.09093291182503078 0.08823100547121235 0.056733206956042094 0.08785239364999109 0.3386773189334231 1.150830264338833e-07 6.938988725629011 5.742882027234049 K(ub)YGTCPHGGYGLGLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYGTCPHGGYGLGLER 16 1 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 1 42318600.0 3695000.0 9723600.0 28900000.0 True False 4783250.339339025 9182473.112268649 23640496.539041303 1.0 1.9197140983295329 4.942349837852742 22.189559868461846 -6.949384119197205 0.5655641349702311 0.9615597163094158 6.046347486444124 0.9991520653600544 0.04903848534161178 0.08373398773039534 0.03699308141157217 0.05222006719951611 0.2515779423241218 1.1236107375743989e-07 6.949384119197205 5.084787770134708 K(ub)YKEALLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYKEALLGR 9 2 P52565;J3KTF8;J3QQX2;J3KRE2;J3KRY1;P52565-2;J3KS60 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 1 10147200.0 1565600.0 1735000.0 6846600.0 True False 2375129.6606914 1425375.6943831265 5493366.509028623 1.0 0.600125423876101 2.3128701560779232 21.179574843075326 -6.845222559085833 1.2580955275578949 0.787206485392288 2.3752176303272905 0.9330339281450557 0.1893195585482485 0.16279378640364156 0.49828388183840944 0.11788837997110513 0.27206832081365506 1.4281618933443277e-07 6.845222559085833 1.5880111449350025 up K(ub)YKEALLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYKEALLGR 9 2 P52565;J3KTF8;J3QQX2;J3KRE2;J3KRY1;P52565-2;J3KS60 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 1 1672330.0 393940.0 665670.0 612720.0 True False 327578.5645010438 662083.9035848503 740836.9191028111 1.0 2.021145384141094 2.261554934863421 18.321481430012117 -10.582079041284999 0.29938241091426837 7.719233415806081e-14 2.337734591806906 0.9991106273853941 0.016310324406237947 2.190708757079894 0.14661269766795218 1.7170367911622058 0.08644359108763686 2.617706544143994e-11 10.582079041284999 2.3377345918068286 K(ub)YKEALLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYKEALLGR 9 2 P52565;J3KTF8;J3QQX2;J3KRE2;J3KRY1;P52565-2;J3KS60 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 1 16235300.0 1565600.0 2606700.0 12063000.0 True False 2026700.0625897658 2461634.8535265396 9867657.776832374 1.0 1.214602446097033 4.868829857449772 20.950701165167775 -6.918952775455683 0.8324631306586069 0.9162883799541324 5.444130846504764 0.9938849190702077 0.1388317095432189 0.09879181126269589 0.10883810960930483 0.11895910373233336 0.352845349760007 1.2051669813351535e-07 6.918952775455683 4.5278424665506325 up K(ub)YMEENDQLKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYMEENDQLKK 11 2 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7;A0A2R8Y5M6 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 19690000.0 1041700.0 10127000.0 8521300.0 True False 1580335.0584710205 8319757.727387847 6837061.31998153 1.0 5.264553034365536 4.326336547008209 20.591799036554203 -10.117550994125887 5.844025616834604 0.9999735632493264 4.795444790687056 0.956179101784759 0.38302527704929257 0.00013193282094858016 1.9922800519437925e-05 0.3708651681122056 0.12362087659893731 7.628673113089043e-11 10.117550994125887 3.7954712274377296 K(ub)YMEENDQLKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYMEENDQLKK 11 2 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7;A0A2R8Y5M6 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 4237280.0 801430.0 824950.0 2610900.0 True False 1097740.3288313982 788500.9812551559 1994259.193173388 1.0 0.7182946281062265 1.8166948419362354 20.066105393601024 -6.838655025490416 1.2885711241270985 0.8501006480123956 1.8518833600109186 0.922126657946096 0.129988678214999 0.17037464886799505 0.5500940193123891 0.0791176445707358 0.18221697307252424 1.449923118257324e-07 6.838655025490416 1.001782711998523 K(ub)YMEENDQLKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYMEENDQLKK 11 2 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7;A0A2R8Y5M6 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 13357800.0 1041700.0 6963900.0 5352200.0 True False 1348501.1849768509 6576352.843239912 4378154.518209578 1.0 4.876786847875707 3.246681995525822 20.362925358646653 -9.445926480771199 10.41774184848341 1.000000000000431 4.061734421720143 0.8246762345484013 0.6654875192486893 0.0 0.0 0.6443555197897648 0.2147851732632549 3.581570623315682e-10 9.445926480771199 3.061734421719712 K(ub)YMPAVTSTPTVNQHETSTSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYMPAVTSTPTVNQHETSTSK 21 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 24392300.0 8626900.0 7369700.0 8395700.0 True False 8353043.781626312 10312459.642477795 6196614.304398846 1.0 1.2345750737188153 0.7418390788312598 22.99387056912558 -6.777241234933055 1.5464752571787153 1.1333003804926407 0.7382594513692899 0.7575314460204214 0.09909053157715647 0.25489792671698563 1.2038709327901964 0.050475309702034905 0.11938527845779619 1.6701626414508893e-07 6.777241234933055 -0.39504092912335076 K(ub)YMPAVTSTPTVNQHETSTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYMPAVTSTPTVNQHETSTSK 21 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 7190200.0 2042700.0 3024200.0 2123300.0 True False 2797941.3918918623 2890580.844307952 1621820.2707361653 1.0 1.0331098616592003 0.5796476922054296 21.415934312201205 -6.889337567473073 1.0263180512047931 1.0247534912462717 0.5411517237527678 0.9804700092038697 0.028844783751707587 0.11968126877293721 0.22501252170536892 0.021433427004273146 0.053306809621412626 1.2902160274477184e-07 6.889337567473073 -0.4836017674935039 K(ub)YNCTLCSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYNCTLCSR 9 1 Q9H9Y6;Q9H9Y6-3;Q9H9Y6-2;Q9H9Y6-4;Q9H9Y6-5 Q9H9Y6 POLR1B DNA-directed RNA polymerase I subunit RPA2 1 4340610.0 1000100.0 970610.0 2369900.0 True False 1294649.1649182574 916594.7002652382 1938602.5172274748 1.0 0.7079869397074156 1.4973960280195877 20.304129766381514 -6.80653822783652 1.42885045997543 0.8401891645325962 1.5101634972005322 0.8506396922612377 0.12594739963733664 0.21156040164009388 0.8518789581269243 0.06931969408242111 0.16063040563249995 1.5612116096314404e-07 6.80653822783652 0.669974332667936 K(ub)YNWSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYNWSAK 7 1 P61927;D6RG19 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 1 8419700.0 1177300.0 2867000.0 4375400.0 True False 1139927.255921439 4011808.051207485 3229351.4808136006 1.0 3.519354441581989 2.8329452287753347 20.120510331547596 -10.255990561378427 5.474348996843874 0.999816040817606 3.1761498351787747 0.9305622987059797 0.28022538768735944 0.0006292121383496725 8.551608645658442e-05 0.2713485133783362 0.0904423549747475 5.546377668967091e-11 10.255990561378427 2.1763337943611685 K(ub)YSEYQSIN ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYSEYQSIN 9 1 A0A087WV34;Q8WWB7-2;Q8WWB7;V9GXZ9;V9GYY1 A0A087WV34 GLMP Glycosylated lysosomal membrane protein 1 5135900.0 1840000.0 1409900.0 1886000.0 True False 2412257.8185853474 1199548.4157471554 1690854.8117894635 1.0 0.4972720604344948 0.7009428257469817 21.201952677937335 -10.206547707207681 5.452985939551073 1.0000188948651505 0.5991074430906955 0.8378149635971639 0.08314824175644138 1.910097431886582e-05 2.7793130966010985e-06 0.08051172891695063 0.02683597963240513 6.215159705320027e-11 10.206547707207681 -0.400911451774455 K(ub)YSEYQSIN ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYSEYQSIN 9 1 A0A087WV34;Q8WWB7-2;Q8WWB7;V9GXZ9;V9GYY1 A0A087WV34 GLMP Glycosylated lysosomal membrane protein 1 7359700.0 1951400.0 1361000.0 4047300.0 True False 1889453.8751423575 1904454.3975212404 2987190.7136026123 1.0 1.0079390783634519 1.5809810193845286 20.84953786965499 -6.909918643880859 0.8962910320149242 0.9822116609679639 1.6549077119672946 0.9908907259099662 0.02596276247176679 0.1044719300525169 0.13906033176266272 0.021247487796607283 0.05861949445694411 1.230499257895085e-07 6.909918643880859 0.6726960509993307 K(ub)YSEYQSIN ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYSEYQSIN 9 1 A0A087WV34;Q8WWB7-2;Q8WWB7;V9GXZ9;V9GYY1 A0A087WV34 GLMP Glycosylated lysosomal membrane protein 1 4918000.0 1840000.0 1135800.0 1942200.0 True False 2520297.724130334 1085616.60041167 1483492.3608645878 1.0 0.43074934759395467 0.5886179028219727 21.265162739460227 -10.629303100107776 9.980545041816526 1.0000978857090657 0.5096836252080689 0.9278590666457005 0.06444956778983829 0.00014040418024901578 5.214861478431938e-06 0.06241516744741132 0.02080100856002581 2.3479935518023255e-11 10.629303100107776 -0.4904142605009968 K(ub)YSEYQSIN ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYSEYQSIN 9 1 A0A087WV34;Q8WWB7-2;Q8WWB7;V9GXZ9;V9GYY1 A0A087WV34 GLMP Glycosylated lysosomal membrane protein 1 6730400.0 1951400.0 2557700.0 2221300.0 True False 1622675.561677763 2543921.1624362986 2685763.559869226 1.0 1.5677324676080133 1.6551451339368695 20.629943145089268 -11.535902627774913 0.31920799068438643 4.845797927581325e-13 1.675018014919362 0.9994333985201795 0.00691335343400406 3.990543100428162 0.16810061662099318 2.7691379172625226 0.029144380011489397 2.911369796812018e-12 11.535902627774913 1.6750180149188776 K(ub)YSEYQSIN ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYSEYQSIN 9 1 A0A087WV34;Q8WWB7-2;Q8WWB7;V9GXZ9;V9GYY1 A0A087WV34 GLMP Glycosylated lysosomal membrane protein 1 13750600.0 5659200.0 5523000.0 2568400.0 True False 7325945.959509454 5215640.194892815 2100977.554009471 1.0 0.7119408501945945 0.2867858383915997 22.80458362824189 -7.086128487633357 0.3729904553805341 1.0344292962653243 2.8425089792862725e-11 0.9998815280589382 0.0031886696787831862 0.07512173457098731 0.017067550340613205 0.0063171598737521255 0.03528512271922639 8.201088761814842e-08 7.086128487633357 -1.0344292962368993 down K(ub)YVDKLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYVDKLEK 8 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 12721100.0 2507500.0 5844200.0 4369400.0 True False 3287356.7826645384 4972268.140513171 3917296.402244374 1.0 1.5125428936505465 1.1916249623106756 21.6484966124925 -10.285609958442855 6.511313395535678 0.9999921474769321 1.3520839279806103 0.6161054855432093 0.13101419684870186 1.4935771336046233e-05 1.6385582574140686e-06 0.12685677865084616 0.04228465020931353 5.180719054630381e-11 10.285609958442855 0.3520917805036782 K(ub)YVDKLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYVDKLEK 8 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 14857700.0 4850100.0 4920400.0 5087200.0 True False 4696136.230310511 6885141.37954703 3754709.707271327 1.0 1.46612897111202 0.7995316837354745 22.163042829548687 -6.718724352054827 1.763766601245721 1.2839813867800285 0.8006390249416883 0.5064435020647047 0.1961818041249047 0.35785833690201097 2.174934894983669 0.08833782849544668 0.2221060388195117 1.9110658326429232e-07 6.718724352054827 -0.48334236183834023 K(ub)YVDKLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYVDKLEK 8 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 18857700.0 5558200.0 4856500.0 8443000.0 True False 8432195.758849598 3989819.630992311 6774237.349301635 1.0 0.473164967357997 0.803377618717173 23.007476929781657 -10.646015559466083 5.141019319055314 1.0054769922575102 0.6382712930376011 0.6153831376490757 0.1348087504069269 0.00855485386619437 0.0005890434089428052 0.13194871217601847 0.0435093371040878 2.2593548228777694e-11 10.646015559466083 -0.3672056992199091 K(ub)YVDKLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYVDKLEK 8 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 10986300.0 2507500.0 3465500.0 5013300.0 True False 3434590.512639567 3312382.7511240053 3829261.79215448 1.0 0.9644185351744765 1.1149107231451585 21.711706674015392 -6.84435425931767 1.2619315722232507 0.9810673877484568 1.1203054009049995 0.9316900927951425 0.016784765272450482 0.16378104842374805 0.5047330649842162 0.010420975056297679 0.024044714702966458 1.4310201224468235e-07 6.84435425931767 0.13923801315654272 K(ub)YVDKLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYVDKLEK 8 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 15401500.0 4850100.0 9085000.0 1466400.0 True False 4033073.045861076 9036057.301768702 1773017.460132462 1.0 2.240489373491987 0.43961947625818815 21.943448104982963 -6.721382410538561 1.7544799659178287 1.753603694965642 0.4422438532333691 0.5189164478560263 0.5219183207442223 0.3526676868131464 2.1223439675983404 0.23613974374208546 0.5918062844708939 1.8994050549048856e-07 6.721382410538561 -1.3113598417322727 K(ub)YVDKLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYVDKLEK 8 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 12387700.0 5558200.0 4166600.0 2662900.0 True False 7195199.468501808 3934725.0472642365 2178279.523661352 1.0 0.5468541997326349 0.30274067219361134 22.778603251874106 -9.410246104930518 0.17448634370001878 1.5273556312538457 1.3404410706246367e-13 0.9996722779686359 0.0052297517900483995 0.8398869853391387 0.06672821230010567 0.3907932359910284 0.16237858625942175 3.8882474430084394e-10 9.410246104930518 -1.5273556312537115 KAASLK(ub)SNYNLPMHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAASLKSNYNLPMHK 15 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 7298500.0 1672300.0 1205200.0 4421000.0 True False 1619213.751870739 1686442.645034974 3263007.4728429266 1.0 1.0415194677580788 2.0151801879603917 20.626862017230565 -6.915852522311873 0.8549262332040398 0.9751414282611569 2.15813014121375 0.9929490350552849 0.039388712783890036 0.10067387845843206 0.11871568711859772 0.03321207392258496 0.0958611389512804 1.213800962929907e-07 6.915852522311873 1.182988712952593 up KAASLK(ub)SNYNLPMHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAASLKSNYNLPMHK 15 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 5419700.0 1147400.0 1375600.0 2896700.0 True False 1571624.787319099 1314821.4434991137 2212559.119409148 1.0 0.8366000931697926 1.407816380386418 20.583825396280456 -6.8302506060072625 1.326901438960957 0.9127071456136562 1.4232541297217027 0.9063549277998031 0.07350740860393278 0.1805022187908866 0.6214724636264152 0.04349636699315878 0.10009088055741763 1.478255127220932e-07 6.8302506060072625 0.5105469841080466 KAASLK(ub)SNYNLPMHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAASLKSNYNLPMHK 15 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 6673200.0 1672300.0 2965900.0 2035000.0 True False 1390591.545451327 2949922.108014947 2460509.0912231016 1.0 2.121343335981183 1.769397418869338 20.40726729266484 -10.052823928194835 4.50066640706403 0.999949939461341 1.945370377482339 0.9058411404459418 0.14368131922198166 33182485.48458948 1.7723901727123768 17745.18845053629 0.04918593723514281 8.854745264303083e-11 10.052823928194835 0.945420438020998 KAAWAEYEAEK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAAWAEYEAEKK 12 2 P46100-5;P46100-3;P46100-4;P46100;P46100-2 P46100-5 ATRX Transcriptional regulator ATRX 1 9522000.0 1509100.0 1772300.0 6240600.0 True False 1953559.6988082635 1673669.9470230923 5104874.833963357 1.0 0.8567283344573943 2.6131143251355464 20.89767391282049 -6.887131199808512 1.0392390624433747 0.8990347444445106 2.755935593869317 0.9789963418514708 0.11541209354435086 0.12150017712916401 0.23570937732135314 0.08492222494511294 0.20963311122907874 1.2967874539690117e-07 6.887131199808512 1.8569008494248063 up KACQIFVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KACQIFVR 8 1 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 8644500.0 1964800.0 3692100.0 2987600.0 False True 2575871.8271502685 3141253.071693083 2678471.81108282 1.0 1.2194912179183641 1.0398311681703742 21.296629377475778 -10.864172143759594 9.37326390324198 0.993087113789744 1.1296611930437992 0.40984621365219076 0.07334590817426948 0.010919052431489391 0.0001582275067572376 0.07318432560551957 0.023672290072617005 1.3671867986174056e-11 10.864172143759594 0.13657407925405518 KACQIFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KACQIFVR 8 1 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 9920600.0 1964800.0 3765800.0 4190000.0 False True 2691239.6567235235 3599414.504164703 3200408.2957587386 1.0 1.3374559546089797 1.18919483360137 21.35983943899867 -10.148093028993005 4.219166664662929 0.9999402195352014 1.2633253940840965 0.8079140836494125 0.06052734943052648 21166443.13735353 1.7841277217873779 13779.516713482264 0.02072012160652844 7.110611829332681e-11 10.148093028993005 0.2633851745488951 KADGYNQPDSK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 KADGYNQPDSKR 12 2 O60506;O60506-2;O43390;O43390-3;B4DT28;O43390-2;O43390-4 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 1 4159420.0 999810.0 2215100.0 944510.0 True False 1310760.5921738136 1884615.7143921708 846781.1655796743 1.0 1.4378031546299808 0.646022752465682 20.321972773553334 -6.75661324325196 1.6253105881285583 1.25536838468217 0.6436130218924042 0.6769644920951909 0.18406195880793733 0.2886393583232302 1.5019744791341076 0.0893894039325682 0.2155334919246259 1.751405691733871e-07 6.75661324325196 -0.6117553627897657 KADGYNQPDSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 KADGYNQPDSKR 12 2 O60506;O60506-2;O43390;O43390-3;B4DT28;O43390-2;O43390-4 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 1 4022330.0 1139500.0 1943400.0 939430.0 True False 1103327.1962307657 2719409.754697116 693365.1007041007 1.0 2.4647355417207897 0.628431079259901 20.07342926086929 -6.694218503535848 1.8512598413343546 1.9146248686487983 0.6344008048119593 0.3903355909978262 0.6189573654773225 0.4076514887203488 2.7118227205824907 0.26714034687059085 0.6920183014450879 2.0220016072348323e-07 6.694218503535848 -1.280224063836839 KADGYNQPDSK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KADGYNQPDSKR 12 2 O60506;O60506-2;O43390;O43390-3;B4DT28;O43390-2;O43390-4 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 1 3016150.0 999810.0 1474400.0 541940.0 True False 1369466.7758493205 1409256.1328112055 413944.9336046522 1.0 1.029054634740743 0.3022672334258934 20.385182835076225 -6.8975882618982 0.9763984157616103 1.0322490631691508 0.22960997544853692 0.9853274678548584 0.04069637356517989 0.11320202074485079 0.1876050558719407 0.031396925536088915 0.08074364074750666 1.265935964527542e-07 6.8975882618982 -0.8026390877206139 down KADIDLTK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 KADIDLTKR 9 2 P62269 P62269 RPS18 40S ribosomal protein S18 1 35129000.0 10437000.0 13726000.0 10966000.0 True False 13683008.072051758 11678134.30352895 9831343.513299711 1.0 0.8534771186302327 0.7185074701067181 23.705882091334004 -6.972109215863713 0.20153694863574245 1.078761096884045 0.4894907613191803 0.9999944952038439 0.0002696399466034622 0.07562405799130807 0.006519700046136678 0.004327096389899654 0.014273458695532615 1.0663279286203832e-07 6.972109215863713 -0.5892703355648647 KADIDLTK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KADIDLTKR 9 2 P62269 P62269 RPS18 40S ribosomal protein S18 1 29075800.0 10437000.0 7618800.0 11020000.0 True False 14295840.949319704 7282176.223997552 8417302.964024188 1.0 0.5093912453148892 0.5887938312873258 23.769092152856896 -10.73884962681659 6.936346954968764 1.0069607782170922 0.5490925383012932 0.9772714905287347 0.03241596998165713 0.0034999819182942316 0.00013177263962053966 0.031481900707621586 0.010462209324176457 1.8245273301703272e-11 10.73884962681659 -0.45786823991579895 KAEGGGGGGRPGAPAAGDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAEGGGGGGRPGAPAAGDGK 20 2 Q00839 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 18621200.0 5867600.0 2578600.0 10175000.0 False True 5681336.249761858 3608248.427221357 7509862.256543027 1.0 0.6351055928739655 1.3218478763438468 22.437798860705144 -6.762342025384651 1.6035123369372686 0.7886674120857508 1.324663609829542 0.7005016924403906 0.15353222998839938 0.27900453746716025 1.4143874540767496 0.07552462518192599 0.18109065127672128 1.728454591520247e-07 6.762342025384651 0.5359961977437911 KAEGGGGGGRPGAPAAGDGK(ub)TEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAEGGGGGGRPGAPAAGDGKTEQK 24 3 Q00839 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 11410300.0 2228800.0 4909500.0 4272000.0 True False 2158047.9639834403 6869888.9527042825 3153035.0427471064 1.0 3.183381031079344 1.4610588343583735 21.041295499317883 -6.586776351021456 2.2417414067999255 2.480753679375651 1.4659071165206903 0.0 0.9469169461742016 0.6790236693145729 6.428636474022849 0.35333831395664006 1.0559831475722583 2.589546112488473e-07 6.586776351021456 -1.0148465628549606 KAEGGGGGGRPGAPAAGDGK(ub)TEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAEGGGGGGRPGAPAAGDGKTEQK 24 3 Q00839 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 11628900.0 1446000.0 6461900.0 3721000.0 True False 1980625.276680687 6176391.891354259 2842176.4364005397 1.0 3.118405063326881 1.4349894802734815 20.91752452546697 -6.588733077636771 2.2340349010658516 2.434911106559198 1.4398246309871596 0.0 0.9182714676805475 0.6731965405392268 6.332489265387521 0.34342055080202966 1.023655797865299 2.5779050801950963e-07 6.588733077636771 -0.9950864755720383 KAEGGGGGGRPGAPAAGDGK(ub)TEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAEGGGGGGRPGAPAAGDGKTEQK 24 3 Q00839 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 7847520.0 2228800.0 4656800.0 961920.0 True False 1853345.9525814275 4631712.894097568 1163053.024584436 1.0 2.4991086459850087 0.6275423230964953 20.82170077475216 -6.693430311795904 1.854029613868581 1.936834764755183 0.6337113691507125 0.3864785502232765 0.6335887596930825 0.4094148011380303 2.731109247096051 0.2731026551496124 0.7081702451854666 2.0256746266153858e-07 6.693430311795904 -1.3031233956044703 KAEGGGGGGRPGAPAAGDGK(ub)TEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAEGGGGGGRPGAPAAGDGKTEQK 24 3 Q00839 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 8895600.0 3175800.0 3571900.0 2147900.0 True False 4111135.704376963 3373120.6250475487 1757004.2393151165 1.0 0.8204838924330133 0.427376852932513 21.971105563897 -6.958234059343708 0.4596536064110756 1.0114980967836982 0.22052516739050357 0.9996989662931786 0.004149011097045565 0.08033820012599807 0.02350931563828932 0.005335699101272977 0.03247578893638678 1.1009458041789861e-07 6.958234059343708 -0.7909729293931946 down KAELLDNEK(ub)PAAVVAPITTGYTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAELLDNEKPAAVVAPITTGYTVK 24 2 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 44509800.0 15769100.0 4416300.0 24324400.0 True False 20413410.80543196 4170529.022760293 19897608.789420642 1.0 0.20430338969372652 0.9747321983118048 24.283013921592634 -10.876523566347588 11.607435558912673 1.0151373408095192 0.5895177940027656 0.27457220501699786 0.31452624404244117 0.10978952893251448 0.0011679058331541948 0.2713679094819326 0.10151290876012876 1.32885144701226e-11 10.876523566347588 -0.4256195468067536 KAELLDNEKPAAVVAPITTGYTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAELLDNEKPAAVVAPITTGYTVK 24 2 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 22300700.0 8556200.0 1651500.0 12093000.0 False True 8284588.11442709 2310952.5624587233 8925480.517776411 1.0 0.27894598144648186 1.077359597664638 22.981998541961634 -6.668753770443142 1.94123536129532 0.5392907796265431 1.0741620267814629 0.2738613687705619 0.30637055173262057 0.4639280630874165 3.3691190196177887 0.12709396360352346 0.34018478438225624 2.144105888513295e-07 6.668753770443142 0.5348712471549197 KAETK(ub)LAEAQIEELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAETKLAEAQIEELR 15 2 Q9NR28-2;Q9NR28;Q9NR28-3 Q9NR28-2 DIABLO Diablo homolog, mitochondrial 1 5714100.0 1418000.0 1339100.0 2957000.0 True False 1859011.7319315313 1139311.4997709182 2651038.0055468967 1.0 0.6128586927136616 1.4260469474242867 20.826104444232474 -6.777235376819128 1.5465169139391837 0.7800033700606607 1.4319525418480317 0.7575213158325235 0.16353769576264943 0.2548975421630865 1.203936442353232 0.08330219246973485 0.19702755516788992 1.6701851701023596e-07 6.777235376819128 0.651949171787371 KAETK(ub)LAEAQIEELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAETKLAEAQIEELR 15 2 Q9NR28-2;Q9NR28;Q9NR28-3 Q9NR28-2 DIABLO Diablo homolog, mitochondrial 1 184186300.0 5004300.0 65940000.0 113242000.0 True False 7591888.963335451 54172491.80842854 90859669.06426826 1.0 7.135574831250981 11.96799235382252 22.856027461417554 -7.9080804139184275 0.343146008120551 2.7458454455516507e-21 14.401562507550297 0.9984634386435556 0.17593242373796317 0.11692198919751592 0.07001940861361143 0.6579832902500334 1.2227246464353836 1.2357186067393027e-08 7.9080804139184275 14.401562507550297 KAETK(ub)LAEAQIEELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAETKLAEAQIEELR 15 2 Q9NR28-2;Q9NR28;Q9NR28-3 Q9NR28-2 DIABLO Diablo homolog, mitochondrial 1 9348800.0 1418000.0 1409800.0 6521000.0 True False 1942272.9200091348 1347510.3744148382 4980874.104210674 1.0 0.6937801379676861 2.564456340248644 20.889314505755365 -6.864892557849967 1.1606799841943403 0.8311379276919266 2.6639243325869706 0.9593196304017957 0.16524018625985828 0.14185119579533612 0.360375256471426 0.11079018611587711 0.2602306207317092 1.3649207689776158e-07 6.864892557849967 1.832786404895044 up KAETK(ub)LAEAQIEELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAETKLAEAQIEELR 15 2 Q9NR28-2;Q9NR28;Q9NR28-3 Q9NR28-2 DIABLO Diablo homolog, mitochondrial 1 166350300.0 5004300.0 45567000.0 115779000.0 True False 6478164.9995004935 43031156.39338776 94708409.99286038 1.0 6.642491569249274 14.619635344293172 22.627153783510003 -6.966222673597482 0.33641080787629246 0.097987646261371 21.427806124011138 0.9999361731776081 0.04463833748380532 0.07754849246523754 0.013410447898784324 0.11388815803256838 0.6923049051866617 1.0808796152998151e-07 6.966222673597482 21.329818477749768 KAEVEGK(ub)DLPEHAVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAEVEGKDLPEHAVLK 16 2 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 6556900.0 2337200.0 2746500.0 1473200.0 True False 3064091.8334769965 2336732.9057731484 1320767.3959322588 1.0 0.7626184307673073 0.43104693583335263 21.547028106050636 -6.966415005729447 0.33287670199816577 1.03906469979214 0.14369940756713265 0.9999394093278311 0.0018162526455677177 0.0774840389990203 0.013184625165798672 0.004789812559778201 0.028854321214394973 1.0804010417430804e-07 6.966415005729447 -0.8953652922250074 down KAEVEGK(ub)DLPEHAVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAEVEGKDLPEHAVLK 16 2 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 8818000.0 2215800.0 2611200.0 3991000.0 True False 2145460.6418675995 3653865.7772281114 2945637.3725664113 1.0 1.7030681924080706 1.3729626706189617 21.0328560046434 -10.10159614668854 4.453712012098459 0.9999525849034715 1.538015431511839 0.7798224193796972 0.13476501508704625 20520271.022696547 23271323.832305033 8706.948219588676 0.04613364803452927 7.91414227252422e-11 10.10159614668854 0.5380628466083676 KAEVEGK(ub)DLPEHAVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAEVEGKDLPEHAVLK 16 2 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 37663500.0 8742700.0 8432800.0 20488000.0 True False 13263315.076984352 6927900.95423287 16438537.819790613 1.0 0.5223355483920277 1.2393988776091267 23.660938076719397 -6.727135148749534 1.7336041743882147 0.7116334667278181 1.238760279625781 0.5459809738232819 0.2008478058841729 0.34162777499504676 2.0100757752995904 0.09186032106135547 0.22869445744943537 1.8744111164993904e-07 6.727135148749534 0.5271268128979629 KAEVEGK(ub)DLPEHAVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAEVEGKDLPEHAVLK 16 2 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 7225200.0 2337200.0 2202300.0 2685700.0 True False 3201326.000455117 2104995.103967795 2051392.9737277438 1.0 0.6575385023794947 0.6407947748639493 21.610238167573527 KAEVEGK(ub)DLPEHAVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAEVEGKDLPEHAVLK 16 2 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 8259900.0 2215800.0 4470000.0 1574100.0 True False 1842535.8765837785 4445919.222774468 1903237.032183925 1.0 2.412934955175792 1.0329443547729944 20.813261280077676 -6.640740882584653 2.042504974948604 1.9234828327626898 1.0387653514964514 0.15727129742860912 0.604446157560288 0.531434405007224 4.238454750243871 0.2409605227985977 0.6690341911425074 2.2869628897058476e-07 6.640740882584653 -0.8847174812662384 KAEVEGK(ub)DLPEHAVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAEVEGKDLPEHAVLK 16 2 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 40670000.0 8742700.0 9825300.0 22102000.0 True False 11317597.494381417 9278513.41786717 18079662.785670977 1.0 0.819830659508209 1.5974823980660706 23.432064398811846 -6.845705485935668 1.2555782565458016 0.9040989354710819 1.6260974946915847 0.9338300721552535 0.08549553376516718 0.16224272527274453 0.4943489685656995 0.05333544184585043 0.12313368670136132 1.42657468827972e-07 6.845705485935668 0.7219985592205028 KAEVTLDGVWPTDK(ub)TSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAEVTLDGVWPTDKTSR 17 2 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 25547500.0 10433000.0 8903600.0 6210900.0 True False 13505724.165175669 8408106.833106576 5080579.929215622 1.0 0.6225587558486325 0.3761797491996638 23.687067662184884 -8.394707767249498 0.17122447764838114 1.3575855903585856 1.4895731198152426e-06 0.9998540818541468 0.003098913494280992 0.11516898586462603 0.03993837282399287 0.14260739885337773 0.13206245400467 4.029881100947523e-09 8.394707767249498 -1.3575841007854659 down KAHQLWLSVEALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAHQLWLSVEALK 13 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 0 4280140.0 2083100.0 1272100.0 924940.0 False True 2730964.272769096 1082307.6386069634 829236.0814509786 1.0 0.39630970254676523 0.3036422298597719 21.380979009814777 -13.999999999999998 0.2638321583987921 5.509015881908156 0.27099577838292727 0.9995702484128675 0.006400540161702421 14.589955641993729 0.1625578503956934 35.1549243604503 0.03971138364695272 1.0000000000000041e-14 13.999999999999998 -5.238020103525229 KAHQLWLSVEALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAHQLWLSVEALK 13 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 0 6743500.0 1512100.0 1223300.0 4008100.0 False True 1464099.2131816936 1711770.069425226 2958258.369577405 1.0 1.169162618225379 2.020531356716389 20.481581889008584 -6.939660066263101 0.6627263347035796 0.9903856052864112 2.2478346319869593 0.9981189389730569 0.01936884850812337 0.0879221934251816 0.05532011508917082 0.0188058307101695 0.07338609826228279 1.1490526634022315e-07 6.939660066263101 1.2574490267005483 up KAHQLWLSVEALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAHQLWLSVEALK 13 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 0 61406100.0 8889100.0 20264000.0 32253000.0 False True 13485414.58025801 16647730.876645336 25878180.4130079 1.0 1.2344990046517963 1.9189755167699698 23.684896539043365 -6.952065397427818 0.5356915598709262 0.9896271153431752 2.195224021444166 0.9993535461741822 0.009912716334783613 0.08266687783831288 0.032611197163586715 0.010968545586304949 0.05664697976696984 1.1166950796650233e-07 6.952065397427818 1.205596906100991 KAHQLWLSVEALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAHQLWLSVEALK 13 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 0 9894900.0 2083100.0 3317400.0 4494400.0 False True 2853278.3636608133 3170826.298825212 3432915.285073531 1.0 1.111292308247478 1.203147694523934 21.444189071337668 -6.973325102928141 0.1599133559871699 0.90692347655845 1.4099535438486828 0.9999980635734549 0.0001154398953963591 0.07523780390531595 0.004935916918345527 0.004255037917898691 0.011026244805545874 1.0633467231514648e-07 6.973325102928141 0.5030300672902328 KAHQLWLSVEALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAHQLWLSVEALK 13 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 0 59353100.0 8889100.0 28166000.0 22298000.0 False True 11507115.18035686 26598537.340096116 18239992.79680079 1.0 2.3114861477619484 1.5851056073495502 23.456022861135814 -10.204690541956415 4.973071428799217 0.9998948579691531 1.9482958775568997 0.6944203741220975 0.29654361385378425 0.00034576105449823767 5.529498460458682e-05 0.2871585327471872 0.09570903982272126 6.241794382916604e-11 10.204690541956415 0.9484010195877466 KAIACLLFGGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAIACLLFGGSR 12 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 1413700.0 1413700.0 0.0 0.0 False True 1936383.0938060072 0.0 0.0 1.0 0.0 0.0 20.884932972793447 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 KAIIIFVPVPQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAIIIFVPVPQLK 13 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 0 180414000.0 47190000.0 69150000.0 64074000.0 False True 61866546.98861005 58833089.544588886 57444237.1212079 1.0 0.9509677266361797 0.928518559986606 25.882656178017164 -13.99999994996077 0.105007539474988 1.2389921430475337 0.8842103068904099 0.9997684010983192 0.0004541899278872821 12.044216789133273 0.09747833855536714 0.6164472858058933 0.039419494332481854 1.000000115219591e-14 13.99999994996077 -0.3547818361571238 KAIIIFVPVPQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAIIIFVPVPQLK 13 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 0 165080000.0 66385000.0 46507000.0 52188000.0 False True 64277644.51231179 65077487.630801015 38518397.193559505 1.0 1.0124435661038578 0.5992502912296617 25.93781372588367 -6.899957635960864 0.9615512651913095 1.0171990427058752 0.5559183877256173 0.9865447708381085 0.02226155360612843 0.11143595239696888 0.17760257066355903 0.017365581501338892 0.04517191112666678 1.259048221935584e-07 6.899957635960864 -0.46128065498025794 KAIIIFVPVPQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAIIIFVPVPQLK 13 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 0 423978000.0 124861000.0 122620000.0 176497000.0 False True 189423265.56182215 100737502.9655672 141612290.58861688 1.0 0.5318116687872718 0.7475971347479426 27.497038297134836 -10.01552369094561 4.847672241083907 1.0000060847177579 0.6397044017603742 0.7880084281460392 0.0880940476103375 121616362.25278825 12.418734946835615 8260.03354977121 0.030156935657555173 9.64886675398267e-11 10.01552369094561 -0.36030168295738363 KAIIIFVPVPQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAIIIFVPVPQLK 13 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 0 226736000.0 47190000.0 79160000.0 100386000.0 False True 64637418.26179913 75662449.45288588 76676894.31456725 1.0 1.1705673197904096 1.1862617099588504 25.945866239540056 -13.072774637637222 0.34965890400132127 8.050580924831822e-10 1.188504973084944 0.9997156272498546 0.0014223972686760486 10.828242157838345 0.18838146627496877 7.845463828279216 0.004689187403288388 8.457175877173458e-14 13.072774637637222 1.188504972279886 KAIIIFVPVPQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAIIIFVPVPQLK 13 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 0 130462000.0 66385000.0 32314000.0 31763000.0 False True 55202068.85414479 32139918.068173178 38404496.44448123 1.0 0.582223071260127 0.6957075566488967 25.718219001317948 -10.226365710760103 8.00266828990773 1.000000232493242 0.6389653139545153 0.9310093197379069 0.046329847154136496 1.9217336140562478e-07 1.8626755918229415e-08 0.044858710357455193 0.01495289387169215 5.937919276355821e-11 10.226365710760103 -0.3610349185387267 KAIIIFVPVPQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAIIIFVPVPQLK 13 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 0 359847000.0 124861000.0 116388000.0 118598000.0 False True 161635025.87827072 109910905.48672554 97014380.91824284 1.0 0.6799943569749589 0.6002064242641663 27.268164619227285 -13.999999999999998 0.19506024427988314 2.746480961391797 0.5457914125316368 0.9994874124500188 0.0039112812455061935 12.437555826602653 0.140056803669916 8.271102396433227 0.052741800606701215 1.0000000000000041e-14 13.999999999999998 -2.20068954886016 KALQWHPDK(ub)NPDNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KALQWHPDKNPDNK 14 2 P25686;C9JRD2;P25686-2;C9JXB9;C9J1G2;E7ETU0;C9JX00 P25686 DNAJB2 DnaJ homolog subfamily B member 2 1 8073900.0 1814300.0 4445800.0 1813800.0 True False 2752425.743096836 3652412.254806059 1455301.6349832176 1.0 1.326979397706338 0.5287342042317241 21.39227221158392 -6.795490526658096 1.4743539725148218 1.1814522399724137 0.5189157507280351 0.818621402433392 0.139542279458774 0.22725873262296795 0.9756864469271382 0.07447685400258668 0.17369537205824181 1.6014355803592893e-07 6.795490526658096 -0.6625364892443786 KALQWHPDK(ub)NPDNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KALQWHPDKNPDNK 14 2 P25686;C9JRD2;P25686-2;C9JXB9;C9J1G2;E7ETU0;C9JX00 P25686 DNAJB2 DnaJ homolog subfamily B member 2 1 3704410.0 817210.0 1638400.0 1248800.0 True False 679546.3235413978 1629573.6140030613 1509918.3062011828 1.0 2.398031683124525 2.2219505188879136 19.374212374900456 -10.19801039917608 5.359554785217937 0.9999340895772046 2.309991101006468 0.9866308113564606 0.0718848342833702 5.661741932367802e-05 8.471959506149167e-06 0.06960564603786915 0.023200730501902883 6.338545334361268e-11 10.19801039917608 1.3100570114292636 KANVNLAYLGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KANVNLAYLGAK 12 1 F6VZ39;Q9H0Z9;A6NG75;Q9H0Z9-2;Q9BX46;H0YA61;H0Y8S7;Q9BX46-5;Q9BX46-2 F6VZ39 RBM38;RBM24 RNA-binding protein 38;RNA-binding protein 24 0 6945900.0 2161000.0 1547200.0 3237700.0 False True 2833091.9271537703 1316363.790938363 2902693.8622114235 1.0 0.46463857325689784 1.0245674820469302 21.433945983852468 -10.969698367920628 12.834849351564724 1.1043034951638733 0.744603027651914 0.2171590682924499 0.228590019794827 0.09192258116242885 0.00021701863058679242 0.029820604690179713 0.07377711164788238 1.0722637698205136e-11 10.969698367920628 -0.3597004675119593 KAPDFVFYAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAPDFVFYAPR 11 1 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 33574900.0 8904300.0 10356000.0 14314600.0 False True 11673623.529363872 8810925.16737182 12833462.507339055 1.0 0.7547720847094982 1.0993555235919439 23.476749111839545 -6.71558777571535 1.775059780058477 0.8501070022768523 1.0986941889178419 0.4916438116960592 0.10325276179942051 0.3639792175127032 2.2387767245158035 0.04622940756710933 0.11666550101345144 1.92491795856279e-07 6.71558777571535 0.24858718664098955 KAPDFVFYAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAPDFVFYAPR 11 1 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 25823800.0 8571500.0 1878000.0 15374300.0 False True 8299402.424301879 2627895.1936406214 11347309.610886429 1.0 0.31663667566543774 1.3672441738286876 22.984576032225572 -6.731158661588843 1.7190470752983698 0.5892886352982637 1.3667486826952315 0.5646294480651186 0.2872437990718644 0.3340611817666791 1.9345315005426462 0.13238901255606367 0.3280790707708037 1.8571258639917976e-07 6.731158661588843 0.7774600473969678 KAPDFVFYAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAPDFVFYAPR 11 1 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 26071900.0 8904300.0 9619700.0 7547900.0 False True 12196460.339659644 9194669.845906088 5765241.473880047 1.0 0.7538801906326434 0.4726979232763965 23.539959173362437 -6.969387084895338 0.27242568325031025 1.0678761474669367 0.15022123288176065 0.9999771997040137 0.0010286486465329267 0.0765020669564348 0.009739594080317143 0.005431128127261861 0.026065263591039976 1.0730325964373258e-07 6.969387084895338 -0.917654914585176 down KAQIAIDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAQIAIDIK 9 1 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 12017300.0 3935000.0 4290000.0 3792300.0 False True 5969682.687034151 3524415.9820770137 3042750.242775864 1.0 0.5903858156032091 0.5097004987190632 22.509222817730734 -13.999999999999986 0.22841348604066086 3.5669323259976697 0.46987369330738776 0.9995076682985706 0.004762859823230138 13.242386798399096 0.15133813375652833 15.402622744517071 0.04230026845613655 1.0000000000000327e-14 13.999999999999986 -3.097058632690282 KAQIAIDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAQIAIDIK 9 1 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 11677300.0 3935000.0 5204600.0 2537700.0 False True 5093935.070446305 4914959.43478891 2075864.6390008717 1.0 0.9648649554455915 0.4075169020203068 22.280349139823183 -6.919757388965644 0.8265283928765141 1.0124055661353106 0.31814045129305035 0.9941131268846484 0.02082320369409245 0.09831489130621594 0.10635711555434534 0.017918262643277977 0.053549517852762574 1.202936246296089e-07 6.919757388965644 -0.6942651148422603 down KAQPAQPADEPAEK(ub)ADEPMEH ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAQPAQPADEPAEKADEPMEH 21 2 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 5711080.0 882380.0 1765200.0 3063500.0 True False 854369.3298903934 2470053.5653963923 2261077.446969982 1.0 2.8910840768514876 2.646487143048609 19.704500332593806 -10.204842023591501 5.458634752876598 0.9999192492708181 2.768785609950207 0.9858606828471087 0.09985628007839356 9.814754907916868e-05 1.4296805616044515e-05 0.09668974029244996 0.032228475813057066 6.239617628710273e-11 10.204842023591501 1.768866360679389 KAQPAQPADEPAEK(ub)ADEPMEH ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAQPAQPADEPAEKADEPMEH 21 2 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 12462100.0 1359400.0 4286700.0 6816000.0 True False 2062309.1854521532 3521704.8928600275 5468814.612441069 1.0 1.7076512666978727 2.651791812313561 20.97582920992532 -6.967130692819646 0.3193766914468284 0.8697507831865092 3.5201171531275848 0.9999505697743863 0.004757231786149502 0.07724517518535602 0.012348575255229366 0.014347634710606306 0.0830946897833692 1.0786220821984064e-07 6.967130692819646 2.6503663699410756 KAQPAQPADEPAEK(ub)ADEPMEH ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAQPAQPADEPAEKADEPMEH 21 2 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 3319990.0 873830.0 970260.0 1475900.0 True False 1196908.565367831 927390.7049792453 1127322.8171146347 1.0 0.7748216796278352 0.9418621018625501 20.190881514981687 -10.346602527424908 5.458496699835699 1.000038430122557 0.8583418908508036 0.48951237514320234 0.0681939668156932 3.190161278355381e-05 3.818623289222116e-06 0.06604642223600077 0.022009508149082126 4.501916883343434e-11 10.346602527424908 -0.14169653927175352 KAQPAQPADEPAEK(ub)ADEPMEH ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAQPAQPADEPAEKADEPMEH 21 2 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 3606550.0 882380.0 1981800.0 742370.0 True False 733738.066061917 1971123.6500435004 897596.13466894 1.0 2.686413232753234 1.2233195689116607 19.484905608028082 -6.611737734670893 2.1473458188980676 2.1253739919698664 1.2286220600527136 0.05582960366132028 0.7267454018081196 0.607836992645714 5.313775819475764 0.2792384239949939 0.8065866486340848 2.4449065572892377e-07 6.611737734670893 -0.8967519319171529 KAQPAQPADEPAEK(ub)ADEPMEH ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAQPAQPADEPAEKADEPMEH 21 2 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 16205800.0 1359400.0 9763900.0 5082500.0 True False 1759770.0977801029 9220530.381842108 4157537.150853892 1.0 5.239622149207746 2.3625456280331734 20.74695553201777 -6.543860132921779 2.41285596217786 3.9467570589264835 2.364733549527065 0.0 1.858481472539233 0.8145271026718681 8.869654172413261 0.662829469073703 2.1047007249591436 2.858510995334894e-07 6.543860132921779 -1.5820235093994186 KASGPPVSELITK(ub)AVAASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KASGPPVSELITKAVAASK 19 2 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 1 11090400.0 2749300.0 4976800.0 3364300.0 True False 3604358.9242590745 4234280.839414461 3016194.5086443797 1.0 1.1747667000962938 0.8368185777348464 21.781311252080908 -6.76616393395208 1.5892610219770673 1.100732458939056 0.835192666766329 0.7156269339566079 0.07358743908182971 0.27267850796056786 1.3586089487258146 0.036511258725084574 0.08721704773030789 1.7133104589223538e-07 6.76616393395208 -0.26553979217272694 KASGPPVSELITK(ub)AVAASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KASGPPVSELITKAVAASK 19 2 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 1 26403100.0 10592000.0 10228000.0 5583100.0 True False 10255762.757767681 14312093.738315383 4120718.6205902146 1.0 1.3955172400488154 0.40179543130219114 23.28993145841121 -6.798696861269209 1.4611619600106396 1.2185885188047954 0.3885046119423213 0.8283419995201384 0.16924344213875708 0.2226235677644598 0.9384792130711855 0.09112596194006979 0.2121020164187116 1.5896559456195578e-07 6.798696861269209 -0.8300839068624741 down KASGPPVSELITK(ub)AVAASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KASGPPVSELITKAVAASK 19 2 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 1 31383900.0 17497000.0 6598300.0 7288600.0 True False 26544228.202042315 5420781.812246791 5848005.015293141 1.0 0.20421696841160053 0.220311736727881 24.661894858591864 -10.107169586764694 5.74539820382315 1.0000058440531545 0.2122643525696697 0.9996870073730246 0.006570661650785097 4.918652543115759e-07 7.643103013971813e-08 0.006362062958910722 0.0021206719288845185 7.813226479281638e-11 10.107169586764694 -0.7877414914834848 KASGPPVSELITK(ub)AVAASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KASGPPVSELITKAVAASK 19 2 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 1 8924800.0 2749300.0 2559700.0 3615800.0 True False 3765790.5070388736 2446603.990204039 2761822.5097385347 1.0 0.6496920064010303 0.7333978097231485 21.8445213136038 -10.719096714470533 5.63117923373769 1.0080793270102182 0.6915449080622452 0.9476591597824643 0.03417275110815914 0.0035184312566106375 0.00017551167015869963 0.033586009353770416 0.011029207994665937 1.909427994398649e-11 10.719096714470533 -0.31653441894797296 KASGPPVSELITK(ub)AVAASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KASGPPVSELITKAVAASK 19 2 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 1 22421000.0 10592000.0 9248000.0 2581000.0 True False 8807717.305160843 9198179.188415732 3120675.1668043407 1.0 1.044331791056248 0.35431145876761905 23.070336733845487 -6.891567403346625 1.013041434845071 1.035694390194053 0.29310301144679546 0.9818834939927813 0.04244525947275231 0.11788152084912283 0.21448186280126852 0.03185669976788948 0.0798825763420824 1.2836085364755782e-07 6.891567403346625 -0.7425913787472576 down KATLELTHNWGTEDDETQSYHNGNSDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KATLELTHNWGTEDDETQSYHNGNSDPR 28 1 Q04760 Q04760 GLO1 Lactoylglutathione lyase 0 25721500.0 4908000.0 11181000.0 9632500.0 False True 7445794.822862411 9185663.192448279 7728632.152925278 1.0 1.2336712749918355 1.0379861837173396 22.82799443099879 -10.296062092083952 4.512265973469681 0.9999095041496658 1.1358287293552143 0.3911354726510591 0.07988810398449764 7.27786712385029e-05 1.1353685998331217e-05 0.07740279176553337 0.025783774690663827 5.0575234825385504e-11 10.296062092083952 0.13591922520554844 KAVELGEK(ub)ASGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAVELGEKASGK 12 2 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 6521300.0 2963600.0 2319700.0 1238000.0 True False 2869522.140192623 3245968.3070756956 913730.6607960962 1.0 1.131187754786866 0.3184260710163958 21.452379075084252 -6.865531035404549 1.1574008861180816 1.0725316486515077 0.27468630891348356 0.9600198634403877 0.07123568168333835 0.14121591848905224 0.3563621461842662 0.047882637517286296 0.11257010079303914 1.362915606516192e-07 6.865531035404549 -0.7978453397380242 down KAVELGEK(ub)ASGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAVELGEKASGK 12 2 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 10077900.0 2592400.0 3727200.0 3758300.0 True False 3932860.3298265077 3062052.039253484 3015470.3576785955 1.0 0.7785814350006581 0.7667372102714918 21.907147521167 KAVELGEK(ub)ASGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAVELGEKASGK 12 2 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 6183350.0 2963600.0 2553800.0 665950.0 True False 2464364.709740808 2540042.1725103874 805197.0659950986 1.0 1.0307087106346118 0.3267361615804773 21.23278435051853 -6.896701013176416 0.9818977677872989 1.031976340494729 0.257601845506793 0.984852023954579 0.03998279712252951 0.11387419257357614 0.19143521677602238 0.03071992641838492 0.07868303916141949 1.268524871880847e-07 6.896701013176416 -0.7743744949879361 down KAVELGEK(ub)ASGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAVELGEKASGK 12 2 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 7417740.0 2592400.0 4339300.0 486040.0 True False 3355912.903843705 4097814.1404487337 397585.70719154406 1.0 1.2210728519668343 0.11847319003308103 21.67827384325945 -6.854543106150368 1.2128781948090008 1.1186041054541334 0.07034909905879598 0.9466808718595293 0.10998033314615199 0.15251704206129454 0.42946144796190766 0.07086248661345404 0.16453861237754167 1.3978381652002415e-07 6.854543106150368 -1.0482550063953373 down KAVIFCLSADKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAVIFCLSADKK 12 2 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 24007400.0 8957300.0 8713200.0 6336900.0 False True 11743107.042616598 7413224.523787588 5681218.375837043 1.0 0.6312830579576982 0.4837917558972667 23.485310837729415 -13.999999999999352 0.12635824603139045 2.752344677257014 0.26735906170621043 0.9996624003484371 0.003988896343230124 11.943883300569995 0.1101661862961436 5.216531939317933 0.19225873235481447 1.000000000001493e-14 13.999999999999352 -2.4849856155508037 KAVIFCLSADKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAVIFCLSADKK 12 2 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 38935000.0 10691000.0 12781000.0 15463000.0 False True 16219028.616793403 10500130.691591218 12406731.272326337 1.0 0.6473957805783288 0.7649490956246442 23.95118408107249 -10.888816932817091 10.814480279749635 1.018437644795045 0.7061724381014869 0.8928208535700277 0.04799093990601816 0.018728798409110226 0.00019254939071218166 0.04079269073351642 0.015489009252070769 1.2917636731215428e-11 10.888816932817091 -0.31226520669355806 KAVIFCLSADKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAVIFCLSADKK 12 2 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 24867800.0 8957300.0 7985200.0 7925300.0 False True 12269055.871930785 7632387.460474794 6053507.366677026 1.0 0.6220843347804954 0.4933963484937968 23.548520899252306 -13.999999999999998 0.15038242540991706 2.8284638255449437 0.3524346427645428 0.9995649679015909 0.004484358999853628 11.959150537470304 0.12214973511928821 6.389010431106924 0.12710170886538172 1.0000000000000041e-14 13.999999999999998 -2.476029182780401 KAVIFCLSADKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAVIFCLSADKK 12 2 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 54773000.0 10691000.0 26392000.0 17690000.0 False True 13839710.251115983 24923261.999567438 14470601.514728056 1.0 1.8008514302210712 1.045585583235834 23.72231040316494 -10.149357705783112 3.86954703790493 0.9998006428107545 1.4232185060528968 0.29511275827050365 0.30833599186464733 217382349.79695022 493810167.53048754 627510.465984974 0.1128394542733331 7.089935662725188e-11 10.149357705783112 0.42341786324214226 KAVLFCLSEDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAVLFCLSEDKK 12 2 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 184625000.0 56928000.0 52591000.0 75106000.0 False True 74633159.2915362 44744627.798112445 67334751.58762427 1.0 0.5995274516428882 0.9022095838740729 26.15331342226012 -9.749126972009563 5.827152330905824 1.0000000128056297 0.750868517756639 0.47459122948530885 0.12356946304386823 2.057329035428069e-08 4.283399933747164e-09 0.11964562524574464 0.039881872704771164 1.7818577404864257e-10 9.749126972009563 -0.24913149504899068 KAVLFCLSEDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAVLFCLSEDKK 12 2 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 48256400.0 23167000.0 9252400.0 15837000.0 False True 22431576.26597464 12946931.570628596 11688814.600183975 1.0 0.5771743999224506 0.5210875268678361 24.419027666321117 -13.999999999862958 0.2847132904538982 4.537144645193147 0.5049728853009577 0.9996156494591785 0.00419095686363842 15.659016991047832 0.16910589063958173 32.34123286917718 0.021701214397590266 1.0000000003155518e-14 13.999999999862958 -4.03217175989219 KAVLFCLSEDKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAVLFCLSEDKK 12 2 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 175776000.0 41621000.0 86850000.0 47305000.0 False True 63142099.902680546 71350938.93785278 37955146.01548194 1.0 1.1300057972070034 0.6011068062985129 25.912098905046264 -6.841691853751128 1.274494539172564 1.069151972648987 0.5831177835741347 0.9273284825584258 0.06066313882309099 0.16683075629027286 0.5256631575237356 0.037311875643561 0.08600323538026323 1.4398198155265513e-07 6.841691853751128 -0.4860341890748524 KAVLFCLSEDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAVLFCLSEDKK 12 2 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 144741000.0 56928000.0 46400000.0 41413000.0 False True 77975820.02135412 44349894.57571889 31632102.327507533 1.0 0.568764708900444 0.4056655296327105 26.21652348378301 -13.999998892411535 0.13484692006020688 3.052532772345731 0.19071798428823836 0.9996242533377679 0.004860231659794265 11.932204266368835 0.11464644222343813 6.465797925912969 0.19157169933286794 1.0000025503199416e-14 13.999998892411535 -2.861814788057493 KAVLFCLSEDKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAVLFCLSEDKK 12 2 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 42642600.0 23167000.0 6346600.0 13129000.0 False True 19264386.972116772 6312409.606098527 15874213.198362725 1.0 0.327672487852071 0.8240186008170944 24.199432941755394 -9.93025437629481 6.518147158091625 1.0000000451611122 0.575845544334832 0.49333300275240843 0.20263245209639963 1.32926700258947e-07 2.1977928689685655e-08 0.19619804855756987 0.06539934269753729 1.174209591840842e-10 9.93025437629481 -0.42415450082628015 KAVLFCLSEDKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAVLFCLSEDKK 12 2 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 180045000.0 41621000.0 85670000.0 52754000.0 False True 53879204.97256551 80902389.19001755 43153313.30175037 1.0 1.5015512799643544 0.8009270612608964 25.683225227138713 -6.7145505957785945 1.7790101094522275 1.306903247263415 0.8023457014889632 0.48663777958715926 0.21120791232509145 0.3660193826051206 2.2608050703615845 0.09438093709225731 0.23845582617394892 1.9295205318583527e-07 6.7145505957785945 -0.5045575457744518 KAVLVALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KAVLVALK 8 1 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 15639500.0 4482100.0 5731800.0 5425600.0 False True 5876076.504718136 4876637.782381402 4864210.958030184 1.0 0.8299139363597046 0.8277991197229163 22.486421748788644 KAVLVALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAVLVALK 8 1 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 5632010.0 2711600.0 945110.0 1975300.0 False True 2625521.7422547974 1322497.3516835389 1457909.6722702156 1.0 0.5037083983725759 0.5552837932388109 21.324172712167357 -10.720986132896764 10.553963431220001 1.0005343933940543 0.5294960961858404 0.9910685157638797 0.02105556678413917 0.0002650119863944851 7.0060638876909575e-06 0.02040667771706719 0.006795654958327421 1.9011389826739678e-11 10.720986132896764 -0.4710382972082139 KAVLVALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KAVLVALK 8 1 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 27746800.0 6291700.0 12816000.0 8639100.0 False True 9544968.884882534 10528884.668134967 6931578.098347952 1.0 1.1030821362666539 0.7262022728357229 23.186309063999083 -6.833801480049233 1.3107062045393194 1.0549549229563084 0.7152409212471987 0.913280778419419 0.046832867648514645 0.17617297678398122 0.5905383594392515 0.02804160148119445 0.06453959250842232 1.4662179093156576e-07 6.833801480049233 -0.3397140017091097 KAVLVALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAVLVALK 8 1 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 13935400.0 4482100.0 3259100.0 6194200.0 False True 6139253.494198127 3115102.185597526 4731257.533553407 1.0 0.5074073237961976 0.7706568132468646 22.549631810311535 -10.051753478656588 5.171442399270259 1.000004504704997 0.6390320685204961 0.7148496977522094 0.10747115403733262 5.581838214150302e-06 1.0235209065731868e-06 0.10405979576746542 0.03468616581483718 8.87659737009435e-11 10.051753478656588 -0.3609724361845009 KAVLVALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KAVLVALK 8 1 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 8619000.0 2711600.0 3517900.0 2389500.0 False True 2254815.5442479337 3498948.374451524 2889133.402200294 1.0 1.5517670096684364 1.2813169616337419 21.104577987601633 -10.009566015658045 4.350337828936629 0.9999800236755665 1.4165419854276147 0.7597814615304294 0.11041077007422033 12571345.36395725 5785008.795668057 2306.7201068537083 0.03779654389610919 9.782142483921393e-11 10.009566015658045 0.4165619617520482 KAVLVALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAVLVALK 8 1 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 33737700.0 6291700.0 16861000.0 10585000.0 False True 8144729.677948416 15922670.52798981 8658638.611271705 1.0 1.9549661139890142 1.063097113549966 22.957435386091532 -6.629990456852698 2.0801548747299727 1.6291369720547162 1.0666601353950136 0.11757854587132777 0.4096273681032376 0.5590239032994008 4.609527184367023 0.1610479722696229 0.4538655892202673 2.3442803277558855e-07 6.629990456852698 -0.5624768366597026 KAYFLGYMVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KAYFLGYMVHR 11 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 4822600.0 1420300.0 1858900.0 1543400.0 False True 1945423.2921643006 1776767.6514397364 1178880.7073207723 1.0 0.913306455513374 0.605976453591885 20.891652665442752 -6.9476507489472 0.5840650353495906 1.0036204299280493 0.5003549015944229 0.9990037999390323 0.0053358778100033016 0.08444300902306155 0.03997369906738261 0.005566320650728141 0.025702089237934496 1.1281042907081305e-07 6.9476507489472 -0.5032655283336265 KAYFLGYMVHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KAYFLGYMVHR 11 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 17859300.0 2821100.0 6968000.0 8070200.0 False True 3651969.5621946813 6580224.674635718 6601506.40724467 1.0 1.8018290028357402 1.8076564699727236 21.800243310370902 KAYGQALAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KAYGQALAK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 1942030.0 822540.0 236410.0 883080.0 False True 796428.9179356322 330809.7458618636 651774.8561678645 1.0 0.4153663163303167 0.8183716606590387 19.60318607998155 -10.138182987469943 5.534591180210459 1.000006509422635 0.6168689884946414 0.5464993509819112 0.1645262428702305 1.3215234296215838e-05 2.0575000458320886e-06 0.15930455468266438 0.05310061655417336 7.274732233150382e-11 10.138182987469943 -0.38313752092799347 KCIGK(ub)PGGSLDNSEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KCIGKPGGSLDNSEQK 16 2 Q9Y5L4;K7EIT2 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 1 26986500.0 3433700.0 4323800.0 19229000.0 True False 5209173.93709508 3552184.1079964046 15428379.721629892 1.0 0.6819092913563368 2.961770888808831 22.31262317957366 -6.871592846192005 1.125565087894949 0.8182232576839781 3.0994368595329753 0.9662507172945176 0.18520901571702628 0.13534036892889187 0.31947977594923654 0.12756894342977265 0.3029044937062755 1.3440244020079937e-07 6.871592846192005 2.2812136018489975 up KCIGK(ub)PGGSLDNSEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KCIGKPGGSLDNSEQK 16 2 Q9Y5L4;K7EIT2 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 1 18254100.0 3433700.0 5059000.0 9761400.0 True False 4444992.338345986 4777462.202781589 7984925.3604220785 1.0 1.0747964988752527 1.7963867544917587 22.08374950166611 -6.9267879179856005 0.772698271959327 0.9876216995851798 1.933096957048833 0.9958685261780512 0.023081144438229933 0.09434018843378751 0.08610340223851873 0.02063939046457536 0.06648182288808668 1.1836194196377817e-07 6.9267879179856005 0.9454752574636532 KCLEELQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 KCLEELQKR 9 2 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 11328900.0 2967100.0 4238400.0 4123400.0 True False 3889896.8334372765 3606047.2411538013 3696750.122445748 1.0 0.9270290178794656 0.9503465723483325 21.891300462360288 -10.192175806798042 5.181230109544404 1.0000039996658523 0.9386877954265662 0.9021395360429403 0.009519351749822682 4.398384037031868e-07 6.857240553141651e-08 0.009217673944005456 0.0030723575661303617 6.424276034818296e-11 10.192175806798042 -0.061316204239286076 KCLEELQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 KCLEELQKR 9 2 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 7266100.0 2586800.0 1855600.0 2823700.0 True False 2504683.4499427336 2596550.7568261633 2084088.2608157785 1.0 1.0366782105281727 0.8320765088552122 21.256196851764507 -6.860543675762269 1.1830563153863252 1.0199277753937652 0.8220685932960002 0.9542943362539567 0.019042738579476234 0.14623806873299036 0.38862937896959204 0.012551971642592646 0.029316814088768073 1.3786572983490205e-07 6.860543675762269 -0.19785918209776499 KCLEELQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 KCLEELQKR 9 2 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 108388000.0 8363000.0 29081000.0 70944000.0 True False 12687282.417196082 23891268.339109924 56921887.30414024 1.0 1.8830879264363336 4.486531112997807 23.596879744966582 -6.951842211094726 0.5382390894817098 0.961220329924881 5.528263734403982 0.9993380379222918 0.038078420508337964 0.0827543255024397 0.03296531918969711 0.04198395939552318 0.2155424566140792 1.1172691029187981e-07 6.951842211094726 4.567043404479101 KCLEELQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KCLEELQKR 9 2 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 14018300.0 2967100.0 3027300.0 8023900.0 True False 4064117.0528625636 2893543.8760576197 6128820.0774077615 1.0 0.7119735574593133 1.5080323715309634 21.95451052388318 -6.808827342031903 1.4195040532116967 0.8428106081194304 1.521582715551359 0.856735136829478 0.12456577139407879 0.20840225865607512 0.8278699902151315 0.06900589498058021 0.1597078224446221 1.5530042991119274e-07 6.808827342031903 0.6787721074319286 KCLEELQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KCLEELQKR 9 2 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 11584300.0 2586800.0 1623500.0 7374000.0 True False 2151038.814670512 1614753.8832604797 8915869.306476243 1.0 0.7506856093193379 4.144913260359712 21.036602127198783 -6.889221750263192 1.0269519729969516 0.8142074982963561 4.432461088809285 0.980396324109792 0.2162709038880069 0.11977781665853812 0.2255425425731711 0.16062062205400382 0.3993331993124403 1.2905601468258313e-07 6.889221750263192 3.6182535905129294 up KCLEELQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KCLEELQKR 9 2 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 90739000.0 8363000.0 22599000.0 59777000.0 True False 10826068.359375458 21341345.783882413 48898199.36381566 1.0 1.9712923542922804 4.51670890489708 23.36800606705903 -6.954443824743998 0.5077199678842851 0.9522613065296792 5.6469781980684175 0.9995054517101506 0.03297643831811068 0.0817488850298368 0.028945872490243447 0.03813361472363332 0.2100492160461763 1.1105961797790446e-07 6.954443824743998 4.6947168915387385 KDCEVVMMIGLPGAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDCEVVMMIGLPGAGK 16 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 53460700.0 19291200.0 18915500.0 15254000.0 False True 25290950.016246524 16093381.132041525 13675662.406700138 1.0 0.6363296405118583 0.5407334401402517 24.592117894885497 -13.999999999999998 0.1875628793824545 2.933361472499402 0.4704443297483575 0.9994909343322884 0.004464103611885086 12.311999312577084 0.13733489517452804 8.69267685037459 0.06703941404378808 1.0000000000000041e-14 13.999999999999998 -2.4629171427510443 KDCEVVMMIGLPGAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDCEVVMMIGLPGAGK 16 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 20962400.0 7207200.0 5591700.0 8163500.0 False True 6978411.38102183 7824494.970330273 6025234.45024954 1.0 1.1212430083456262 0.8634106132859254 22.734467216994936 -6.778855767946701 1.5405481762184892 1.068753457259904 0.86144893443115 0.7632427851292528 0.05124715331606763 0.2523587595069891 1.182941287278289 0.026203937007217803 0.06188403917447026 1.6639651723927434e-07 6.778855767946701 -0.207304522828754 KDCEVVMMIGLPGAGK ddPTM_RPMI8226_Bortezomib_8h_R1 2 KDCEVVMMIGLPGAGK 16 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 125659100.0 21959800.0 65643200.0 38056100.0 False True 33314622.076424994 53928658.08733743 30534295.15441884 1.0 1.6187684183726612 0.9165433449724275 24.989652191869514 -6.674094890494179 1.9231886787274899 1.393572998265687 0.9193487888318899 0.29712162053396474 0.26259666748565014 0.4518107609387245 3.2255864950374815 0.10978136838908974 0.29171579153179655 2.1178983378034276e-07 6.674094890494179 -0.4742242094337972 KDCEVVMMIGLPGAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDCEVVMMIGLPGAGK 16 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 53079700.0 19291200.0 16981500.0 16807000.0 False True 26423677.96507774 16231201.179688986 12837532.751030358 1.0 0.6142672947021451 0.48583443864237197 24.65532795640839 -13.999999999999998 0.15365870194023457 2.8764709910204442 0.3503084757611413 0.9995544901018939 0.004611741632245408 11.97336362648181 0.12363029309706808 6.702173695112842 0.12261156391718096 1.0000000000000041e-14 13.999999999999998 -2.526162515259303 KDCEVVMMIGLPGAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KDCEVVMMIGLPGAGK 16 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 15363100.0 7207200.0 3009300.0 5146600.0 False True 5993106.133096226 2993088.3036007197 6222730.264810223 1.0 0.49942187525626164 1.0383147113724427 22.514872492429213 -11.922030566769347 18.058750926075355 0.9044661480565027 0.7919814639829171 0.0 0.251358239074612 0.0 0.0 0.0 0.07306787084828913 1.196656304576238e-12 11.922030566769347 -0.11248468407358558 KDCEVVMMIGLPGAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KDCEVVMMIGLPGAGK 16 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 52079000.0 13597000.0 21280000.0 17202000.0 False True 17601584.536939844 20095749.293376595 14071412.507425213 1.0 1.1417011491892866 0.7994401002872225 24.069201973794925 -6.794242025285951 1.4791225342534124 1.0787603954094256 0.7953503016957376 0.8148631156201649 0.060416903969310036 0.22907023638464916 0.9898702203220866 0.03214230373814901 0.07503441760224422 1.6060459801437312e-07 6.794242025285951 -0.28341009371368797 KDDEENYLDLFSHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDDEENYLDLFSHK 14 1 Q07666;Q07666-2;Q07666-3 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 0 23950600.0 7602300.0 2738300.0 13610000.0 False True 7360969.147788624 3831717.470045857 10045132.708751911 1.0 0.5205452424966321 1.3646481199788292 22.811464293848548 -6.752625869915828 1.6401817312525437 0.7189689569329359 1.3666625606782676 0.6601818010430289 0.20150134425484753 0.295481366451934 1.5647500289333298 0.09701795792841643 0.23488262205546176 1.767559858347722e-07 6.752625869915828 0.6476936037453317 KDDEENYLDLFSHKNMK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDDEENYLDLFSHKNMK 17 2 Q07666;Q07666-2;Q07666-3 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 12942000.0 4830700.0 5026500.0 3084800.0 True False 6333094.480565345 4276565.793143539 2765614.48749106 1.0 0.6752726974573379 0.43669244095094856 22.594479171804192 -7.7266840578606235 0.16567659310063768 1.2866344494058364 6.475929334519164e-15 0.9999574056759156 0.0015067074402759985 0.1324753894671042 0.020914658609383158 0.05744526056790281 0.08777580816598313 1.876359032209664e-08 7.7266840578606235 -1.28663444940583 down KDDEENYLDLFSHKNMK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 2 KDDEENYLDLFSHKNMK 17 2 Q07666;Q07666-2;Q07666-3 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 79776900.0 27105300.0 26602400.0 26069200.0 True False 26244857.088191114 37224877.049683325 19240894.4607638 1.0 1.4183684416568103 0.7331300908253469 24.645531405836458 -6.7415058745117244 1.6816068870555334 1.2484961520316387 0.7326280955568721 0.6115274063353977 0.17577446530315574 0.315086881273949 1.7501339308370658 0.08268016607571654 0.2025220384488782 1.8134021466062973e-07 6.7415058745117244 -0.5158680564747665 KDDEENYLDLFSHKNMK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 KDDEENYLDLFSHKNMK 17 2 Q07666;Q07666-2;Q07666-3 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 107050000.0 37058000.0 37255000.0 32737000.0 True False 56219695.30269667 30606554.175356418 26266517.6008632 1.0 0.5444098195581705 0.46721202346330193 25.744572298888887 -13.999999999999998 0.24976540390216836 4.164675379104434 0.4361026641136167 0.9995422483194693 0.005029672977826704 13.988737115715981 0.15814374571998813 22.207702440594662 0.035672981435288194 1.0000000000000041e-14 13.999999999999998 -3.7285727149908174 KDDEENYLDLFSHKNMK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDDEENYLDLFSHKNMK 17 2 Q07666;Q07666-2;Q07666-3 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 17131700.0 4830700.0 6743500.0 5557500.0 True False 6616740.334758912 6445549.872227585 4244932.960305295 1.0 0.9741276740705641 0.6415444381285311 22.657689233327083 -6.922425890045014 0.8065374835338351 1.006716642288709 0.5848024041217038 0.9948285083653046 0.011737761315688426 0.09676547656793312 0.09837377290961828 0.010245409096055678 0.031438890879650086 1.1955675252632972e-07 6.922425890045014 -0.42191423816700524 KDDEENYLDLFSHKNMK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 2 KDDEENYLDLFSHKNMK 17 2 Q07666;Q07666-2;Q07666-3 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 77509600.0 27105300.0 35291800.0 15112500.0 True False 22539257.918388985 35101676.06852621 18272453.87769489 1.0 1.5573572207045907 0.8106945642956168 24.425936681270734 -6.706851658230006 1.806217742380437 1.3437400505217874 0.8125893378306219 0.4502548790103418 0.2349854369419002 0.3814280201433796 2.4236445031048213 0.10360414288337849 0.2642336478152841 1.9640310154642946e-07 6.706851658230006 -0.5311507126911654 KDDEENYLDLFSHKNMK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KDDEENYLDLFSHKNMK 17 2 Q07666;Q07666-2;Q07666-3 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 108652000.0 37058000.0 37052000.0 34542000.0 True False 47972311.52238857 34990023.62867436 28255710.430849962 1.0 0.7293795632996461 0.5890003948978586 25.515698620981336 -13.999999995690134 0.08330697193309208 2.4317607556384306 0.1942867643232968 0.999872669984754 0.0019247696636637134 12.226150555769463 0.08215556798217706 3.179507989545802 0.357061621019031 1.0000000099238337e-14 13.999999995690134 -2.237473991315134 KDEAGENYSK(ub)DQGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDEAGENYSKDQGGR 15 2 Q96SI9-2;Q96SI9 Q96SI9-2 STRBP Spermatid perinuclear RNA-binding protein 1 4998000.0 1232700.0 2016800.0 1748500.0 True False 1616081.637483781 1715901.3014248274 1567581.9927963295 1.0 1.0617664736890795 0.9699893597188786 20.62406864799441 -6.725362965061669 1.739809105342355 1.0373604346181537 0.9700851718329312 0.5377995113835441 0.025975945731100146 0.3449947259368401 2.0435288818747677 0.011841601157145122 0.029543334566766995 1.8820754724796152e-07 6.725362965061669 -0.06727526278522256 KDEAGENYSK(ub)DQGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDEAGENYSKDQGGR 15 2 Q96SI9-2;Q96SI9 Q96SI9-2 STRBP Spermatid perinuclear RNA-binding protein 1 5500200.0 1471500.0 2102700.0 1926000.0 True False 1424788.0379583752 2942319.075435642 1421522.821238515 1.0 2.0650924888812137 0.9977082789629964 20.442315878544385 -6.646691504465689 2.0205568776856606 1.6929511950646547 1.0022060260326222 0.18066240537865308 0.4549673543602767 0.516687291157831 4.039529932698289 0.18286386077017733 0.5038063482151129 2.2558410510198846e-07 6.646691504465689 -0.6907451690320325 KDEAGENYSK(ub)DQGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KDEAGENYSKDQGGR 15 2 Q96SI9-2;Q96SI9 Q96SI9-2 STRBP Spermatid perinuclear RNA-binding protein 1 5783000.0 1740000.0 1321900.0 2721100.0 True False 2639707.21103924 1085996.616948159 2183273.392299504 1.0 0.4114079820695748 0.8270892253387299 21.331946488071974 -10.37580873664372 5.749901383092065 1.0000980840482148 0.6192486037042113 0.5280051444003623 0.1697011569425291 0.00021343295093306208 2.316948184358051e-05 0.1643544894317752 0.05477081288921168 4.2091195726239664e-11 10.37580873664372 -0.38084948034400345 KDEAGENYSK(ub)DQGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDEAGENYSKDQGGR 15 2 Q96SI9-2;Q96SI9 Q96SI9-2 STRBP Spermatid perinuclear RNA-binding protein 1 5216200.0 1232700.0 1582200.0 2401300.0 True False 1688462.5024649247 1512293.172364276 1834162.396325884 1.0 0.8956628708997294 1.0862914596256992 20.6872787095173 -6.758096385881912 1.6197040320572023 0.9392520608689694 1.0869216054434847 0.683132125464585 0.04387318691240778 0.28612206669977364 1.4789758639892634 0.021376855989991003 0.051467583997003734 1.7454347339148973e-07 6.758096385881912 0.1476695445745153 KDEAGENYSK(ub)DQGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KDEAGENYSKDQGGR 15 2 Q96SI9-2;Q96SI9 Q96SI9-2 STRBP Spermatid perinuclear RNA-binding protein 1 4451500.0 1471500.0 1657900.0 1322100.0 True False 1223617.4485030356 1648968.5636326142 1598544.997300278 1.0 1.347617726152851 1.3064091226027594 20.22272115397866 -10.07692894057388 4.419479711365557 0.9999738944010488 1.3270134244034044 0.9882303341539393 0.016823342052710515 2540240.591278385 2896022.5147329927 536.3102066676163 0.005759077526310861 8.376663301939705e-11 10.07692894057388 0.32703953000235564 KDEAGENYSK(ub)DQGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KDEAGENYSKDQGGR 15 2 Q96SI9-2;Q96SI9 Q96SI9-2 STRBP Spermatid perinuclear RNA-binding protein 1 6690100.0 1740000.0 1673700.0 3276400.0 True False 2252464.300527715 1580557.123699457 2680128.8187029418 1.0 0.7017012981422873 1.1898651703714158 21.103072810164424 -6.741317656453205 1.6817387677262718 0.8227879513544747 1.1902426161424637 0.6109184780851207 0.12532929155716607 0.31542825011479 1.7521336438561603 0.05894207588116049 0.14443734790383966 1.8141882238354494e-07 6.741317656453205 0.36745466478798905 KDEDPENK(ub)IEFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KDEDPENKIEFK 12 2 Q13123;D6REL4;E7EQZ7 Q13123 IK Protein Red 1 25599000.0 4177000.0 11877000.0 9545000.0 True False 5407208.84097946 11216034.509277904 7807907.9399705585 1.0 2.0742743324939226 1.4439812053858525 22.366452647591125 -10.598227720638763 6.388000748753149 0.997940378500754 1.7591277689392788 0.659182276090087 0.2573160916329924 0.007561429104903925 0.0004755739233028545 0.24959132760347513 0.08304841146714673 2.5221579418983826e-11 10.598227720638763 0.7611873904385248 KDEK(ub)TDTLEDLFPTTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KDEKTDTLEDLFPTTK 16 2 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 42847100.0 7071100.0 11825000.0 23951000.0 True False 10727375.66665492 9714736.360853313 19217074.351903796 1.0 0.9056023264898511 1.7914049949456268 23.354793844147533 -6.8805381812583875 1.076750101400221 0.9410613928505371 1.8548436352135569 0.9741187900715147 0.06389939155642595 0.12715639025967607 0.2693909126498827 0.04569081456365418 0.11064868362857261 1.316624155835388e-07 6.8805381812583875 0.9137822423630197 KDEK(ub)TDTLEDLFPTTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KDEKTDTLEDLFPTTK 16 2 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 42329100.0 7071100.0 10922000.0 24336000.0 True False 9153678.342219265 10314181.098790392 19907097.70844667 1.0 1.1267799362381536 2.1747648283236805 23.125920166239982 -6.92949156462019 0.7509525875244251 0.9837597117137669 2.387152432065749 0.9964374556490896 0.03142269890322765 0.09290238593864038 0.07897923167484504 0.028541646325657404 0.09509078763052273 1.1762738314409707e-07 6.92949156462019 1.403392720351982 up KDETK(ub)TQAIVCQQLDLTHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KDETKTQAIVCQQLDLTHLK 20 2 P61221;D6R9I9;D6RGF4 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 62845000.0 10837000.0 10490000.0 41518000.0 True False 16440521.290823137 8617977.54125591 33311949.102014177 1.0 0.5241912582216198 2.0262100278175748 23.97075270847214 -6.821540019349802 1.3653956044964772 0.7439398177276004 2.060042227631781 0.8878444489008263 0.2099028433920153 0.19149094428768407 0.701088219238359 0.12079794283769155 0.2782847658417105 1.5082036262521803e-07 6.821540019349802 1.3161024099041807 up KDETK(ub)TQAIVCQQLDLTHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KDETKTQAIVCQQLDLTHLK 20 2 P61221;D6R9I9;D6RGF4 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 45708400.0 10837000.0 7613400.0 27258000.0 True False 14028710.129206242 7189707.597283532 22297323.690698568 1.0 0.5124995477891688 1.5894065445317012 23.74187903056459 -6.783625738748568 1.52162478380661 0.7252628954573822 1.5989449699332061 0.7800385986402617 0.20650139934443304 0.2449867479627462 1.1205487865455075 0.10686215142130703 0.25140927033779276 1.6457894015358253e-07 6.783625738748568 0.8736820744758239 KDFLAMFSPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDFLAMFSPK 10 1 O60711;O60711-2;B7Z5P7 O60711 LPXN Leupaxin 0 8240400.0 2362000.0 1961200.0 3917200.0 False True 3096604.873640541 1668596.6046977264 3511885.720435676 1.0 0.5388471157238836 1.1341084393201604 21.562255876390118 -6.699880967029734 1.8313053661470726 0.7136087998708869 1.1323329829449322 0.41700569112527497 0.19466261916344932 0.3957711942295653 2.5803640352136923 0.0848046640554116 0.21812635056874827 1.9958092584838842e-07 6.699880967029734 0.41872418307404535 KDFLAMFSPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDFLAMFSPK 10 1 O60711;O60711-2;B7Z5P7 O60711 LPXN Leupaxin 0 7776400.0 2362000.0 2168400.0 3246000.0 False True 3235295.2306499197 2072592.9180601027 2479361.6534684626 1.0 0.6406194088332865 0.7663478837974234 21.62546593791301 -10.390044241061544 5.1474780561132665 1.0002149387736015 0.7034836463153376 0.8811784700448623 0.0513284349667978 0.00012670123029316397 1.5013656210147026e-05 0.04973424337931061 0.01656618115109951 4.0733878057415324e-11 10.390044241061544 -0.2967312924582639 KDGNASGTTLLEALDCILPPTRPTDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDGNASGTTLLEALDCILPPTRPTDK 26 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 13109500.0 1671700.0 9713900.0 1723900.0 False True 2191614.888765827 8264623.984485623 1545527.3648164677 1.0 3.7710201855489838 0.7052002487931659 21.063562879082557 -6.668594505576646 1.9420848401951412 2.770762248882386 0.7175335012254747 0.27309759063959305 1.177429887124119 0.4642510182617271 3.374346970036261 0.4882890766810104 1.3071104179062152 2.1448923211621928e-07 6.668594505576646 -2.0532287476569113 KDGNASGTTLLEALDCILPPTRPTDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDGNASGTTLLEALDCILPPTRPTDK 26 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 16677300.0 1671700.0 6903500.0 8102100.0 False True 2289772.6659938446 6598480.543178339 6188550.847987322 1.0 2.881718626994946 2.7026922540807194 21.12677294060545 -9.873354486131328 5.995626306169141 0.9999996849389311 2.792205440539038 0.9925718330508898 0.07308721069446816 3.0780561842258234e-07 5.803990268543497e-08 0.07076640011085489 0.023588795819407593 1.3385836432702203e-10 9.873354486131328 1.792205755600107 KDGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDGNASGTTLLEALDCILPPTRPTDKPLR 29 3 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 145138800.0 49353400.0 66118000.0 29667400.0 False True 64702785.33900545 56253452.12594546 26597702.037795752 1.0 0.8694131455270382 0.4110750703920869 25.947324483203303 -6.947880674818735 0.5816556222911973 1.0054454161431328 0.25230850606785454 0.9990242184076342 0.007888519158497021 0.08434830621842591 0.039573233431389354 0.008250376240273317 0.038304957130081384 1.1275072034227407e-07 6.947880674818735 -0.7531369100752783 down KDGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDGNASGTTLLEALDCILPPTRPTDKPLR 29 3 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 369976300.0 195981300.0 78148000.0 95847000.0 False True 189759980.90623987 109352903.93643636 70741795.35163443 1.0 0.5762695770425244 0.37279617658998315 27.499600528930642 -12.187473106071254 0.11696428157134779 2.3761922608162664 1.2981731391149608e-13 0.9997712449096876 0.003951534479629833 6.02270319667891 0.08546278244510361 2.3029607238277503 0.28570797329137265 6.494218461421677e-13 12.187473106071254 -2.3761922608161368 KDGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KDGNASGTTLLEALDCILPPTRPTDKPLR 29 3 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 932395200.0 11934000.0 876480000.0 43981200.0 False True 18104750.492265705 720065296.0305039 35288296.54235524 1.0 39.77217450956386 1.9491180813251359 24.109864958890785 -6.243373512149077 23.08983562889501 9.999999999999998 1.949098946993861 0.011114621915805922 17.957193312875336 1118.2168082034311 3895852.584757974 7.571714065782212 47.76943491828976 5.709873514748887e-07 6.243373512149077 -8.050901053006138 KDGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDGNASGTTLLEALDCILPPTRPTDKPLR 29 3 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 334111290.0 49353400.0 114503790.0 170254100.0 False True 67600685.70548584 109444633.94440202 130043588.07325482 1.0 1.6189870384039688 1.923702203847641 26.010534544726195 -10.203994526083822 0.15683749037062084 1.0092549250779815e-17 2.33594645844522 0.9996722324841314 0.006957613803377682 1.8550785639166363 0.07685959096316279 1.0023782790035873 0.2569738588524398 6.251805726006123e-11 10.203994526083822 2.33594645844522 KDGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KDGNASGTTLLEALDCILPPTRPTDKPLR 29 3 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 303180900.0 195981300.0 25283600.0 81916000.0 False True 162967134.39368546 25147392.228398364 99044256.86320968 1.0 0.15430959329289623 0.6077560192225322 27.28000580436492 -10.1247748670452 5.37068876762597 1.000012334053833 0.3810328063951858 0.7130067846859989 0.1851187282037023 2.7339878328944407e-05 4.455566724807661e-06 0.17924400458155576 0.05974681261686141 7.502830461065229e-11 10.1247748670452 -0.6189795276586472 KDGNASGTTLLEALDCILPPTRPTDKPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KDGNASGTTLLEALDCILPPTRPTDKPLR 29 3 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 84564800.0 11934000.0 44123800.0 28507000.0 False True 15448798.254309073 41668271.742062494 23319018.50652079 1.0 2.697185312161101 1.5094389947138125 23.880991280983235 -10.502358936792012 5.367965388593946 0.9976484207102825 2.1033121534355224 0.5349927403008241 0.48489540360262456 0.013664468645195249 0.0012667738721594758 0.47009819742948367 0.15649931856712115 3.14514782995984e-11 10.502358936792012 1.1056637327252399 KDLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Bortezomib_1h_R1 2 KDLYANTVLSGGTTMYPGIADR 22 1 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 220531300.0 46419000.0 104452300.0 69660000.0 False True 60855758.522235475 88868423.99187656 62452251.42590349 1.0 1.4603124856196774 1.0262340482221528 25.858890449720697 -10.423868896878348 3.3131916748064167 0.997015825153164 1.2432732668460973 0.2951715475175284 0.1772117811902588 128316654.80047697 158075562.56839964 3564888.0752677848 0.06485284972782762 3.768175340212562e-11 10.423868896878348 0.2462574416929333 KDLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Bortezomib_2h_R1 2 KDLYANTVLSGGTTMYPGIADR 22 1 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 252929400.0 84305000.0 36693400.0 131931000.0 False True 81628783.92122388 51345265.97355319 97374313.2548382 1.0 0.629009321308818 1.1928918768263115 26.282574628884145 -6.729260830564783 1.7260336996610206 0.7765511641787978 1.192503348169368 0.5557541068129943 0.15596529212529917 0.3376424757435738 1.970336936631464 0.07161863242474485 0.1778583298203428 1.865259108526e-07 6.729260830564783 0.4159521839905703 KDLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KDLYANTVLSGGTTMYPGIADR 22 1 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 177752000.0 29972000.0 112730000.0 35050000.0 False True 45469715.24670584 92612450.73648994 28122352.137039244 1.0 2.0367941658310578 0.6184853365466509 25.43840263346989 -6.710730263702622 1.7924512412568119 1.6369259709493535 0.6217323860198055 0.46859524669053865 0.4368512231093672 0.37363331600666627 2.340469425809008 0.1939080166270452 0.4922095275983355 1.9465687021207143e-07 6.710730263702622 -1.015193584929548 KDLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 KDLYANTVLSGGTTMYPGIADR 22 1 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 190758000.0 46419000.0 62927000.0 81412000.0 False True 63581358.7263076 60146677.06823839 62184162.33277102 1.0 0.9459797379786402 0.978025062352773 25.92210051124359 -9.977061605735885 4.346602832891333 1.0000011037268053 0.9620024001729385 0.6521323145359395 0.013082448933488573 13600173.867185224 1.5973460071824526 185.08335026268477 0.0047876860693045475 1.0542373396354614e-10 9.977061605735885 -0.03799870355386681 KDLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 KDLYANTVLSGGTTMYPGIADR 22 1 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 170856000.0 84305000.0 39864000.0 46687000.0 False True 70103342.84474924 39649244.71961554 56449035.84370166 1.0 0.5655827969205791 0.8052260213712434 26.06297990431842 -10.12931802740444 5.266113484031571 1.0000081779142982 0.6854044091456865 0.6967682543048239 0.0978339367040176 9.393689460151022e-06 1.5531239883041128e-06 0.09472976271483327 0.0315757672956009 7.42475235178209e-11 10.12931802740444 -0.31460376876861174 KDLYANTVLSGGTTMYPGIADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KDLYANTVLSGGTTMYPGIADR 22 1 P60709;A0A2R8Y793;P63261 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 107702000.0 29972000.0 49780000.0 27950000.0 False True 38799344.8364464 47009699.239863165 22863386.791218165 1.0 1.2116106454381241 0.5892724964196123 25.20952895556234 -6.814945547683502 1.3935037214626351 1.1146742484116163 0.5770945148459957 0.872373028523386 0.09230134763351458 0.20013860945620043 0.7649560194542462 0.05206647517538051 0.12020179674248704 1.531279443135473e-07 6.814945547683502 -0.5375797335656206 KDPGVPNSAPFK(ub)EALLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDPGVPNSAPFKEALLR 17 2 Q9BVP2-2;Q9BVP2;C9JZT7;B4DMU5;C9JYH9 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 1 10125800.0 3433700.0 3593500.0 3098600.0 True False 4501613.951998101 3057363.8073532935 2777986.5958700078 1.0 0.679170590804714 0.6171090247836472 22.102010909230735 -13.999999999999998 0.23097970527796524 3.0345270405682188 0.5872140706348769 0.9995111465646763 0.003709890842209827 13.321989902250568 0.15216672992654612 12.437199689654303 0.03202034892838671 1.0000000000000041e-14 13.999999999999998 -2.447312969933342 KDPGVPNSAPFK(ub)EALLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDPGVPNSAPFKEALLR 17 2 Q9BVP2-2;Q9BVP2;C9JZT7;B4DMU5;C9JYH9 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 1 11454600.0 5133500.0 4561000.0 1760100.0 True False 4970539.852435834 6382231.085300782 1299077.0081318321 1.0 1.284011651606242 0.2613553148548269 22.244971121340157 -6.83260919942372 1.3161876842536395 1.1515034622131928 0.23233516219056044 0.9109999648734443 0.12858874384406696 0.1776108225996286 0.6008179109938414 0.07668662706181144 0.17647922656519036 1.470248688174953e-07 6.83260919942372 -0.9191683000226323 down KDPGVPNSAPFK(ub)EALLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDPGVPNSAPFKEALLR 17 2 Q9BVP2-2;Q9BVP2;C9JZT7;B4DMU5;C9JYH9 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 1 11325300.0 3433700.0 6237200.0 1654400.0 True False 4703231.682253437 5961619.8803377915 1263664.793437532 1.0 1.2675581989364022 0.2686801073835423 22.165220970753627 -6.835415046029262 1.3034713606409898 1.142522462898147 0.23868846567623084 0.9162909382248037 0.12214921117842034 0.17421967389802592 0.5769546831173757 0.0735315836789813 0.16925499047032608 1.4607804702360229e-07 6.835415046029262 -0.9038339972219162 down KDPGVPNSAPFK(ub)EALLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KDPGVPNSAPFKEALLR 17 2 Q9BVP2-2;Q9BVP2;C9JZT7;B4DMU5;C9JYH9 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 1 11256400.0 5133500.0 4655900.0 1467000.0 True False 4268732.702609814 4630817.742576205 1773742.917358373 1.0 1.084822607830427 0.4155197902820066 22.025376396774433 -6.875103041400749 1.1068096451099723 1.0498190465536494 0.3723362505131862 0.9695131794521441 0.051952152444075236 0.13205305791406935 0.2992884727791151 0.036304680940370114 0.08679609367228457 1.3332050762746305e-07 6.875103041400749 -0.6774827960404632 down KDPK(ub)EWAAQYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDPKEWAAQYR 11 2 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 4355900.0 1336600.0 1612400.0 1406900.0 True False 1752295.5436528104 1371836.2050859737 1261327.4839377503 1.0 0.7828794691940285 0.7198143535241807 20.740814690954757 -13.999999999999998 0.17334126180780213 2.1048517315730133 0.6661173173210394 0.9995076998443297 0.0026627657289407317 12.125779111663796 0.13190213489801836 4.506576743626564 0.049893131282828844 1.0000000000000041e-14 13.999999999999998 -1.4387344142519738 KDPK(ub)EWAAQYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDPKEWAAQYR 11 2 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 4588600.0 1210300.0 1396100.0 1982200.0 True False 1171879.6889847254 1953570.0105653198 1463002.3552746524 1.0 1.6670397387447025 1.248423681224602 20.160393032416515 -10.194538089614273 4.749893233244171 0.9999316477669811 1.4577317099867022 0.6145171623626517 0.17089928985034655 0.000123720922729947 2.0979987378692554e-05 0.165497141251344 0.055157508621423004 6.389426966912076e-11 10.194538089614273 0.45780006221972114 KDPK(ub)EWAAQYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KDPKEWAAQYR 11 2 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 1756870.0 1210300.0 0.0 546570.0 True False 1006418.0753810571 0.0 660855.2599458529 1.0 0.0 0.6566408892205511 19.94079830785079 -10.330139510084035 7.636284045529183 1.0000051513037316 0.3283204446102756 0.5824819125068669 0.2680725204729608 2.3510552740425838e-05 2.061976627239322e-06 0.2595620915915167 0.086520033947302 4.675849130622303e-11 10.330139510084035 -0.6716847066934559 KDSFSNLELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KDSFSNLELK 10 1 Q86W26 Q86W26 NLRP10 NACHT, LRR and PYD domains-containing protein 10 0 8099300.0 2196600.0 4600700.0 1302000.0 False True 3332402.7929705735 3779669.1395668276 1044659.1293131269 1.0 1.1342173723835922 0.3134852519979723 21.668131361474224 -6.8649380997422345 1.1604540032300588 1.0740256902876024 0.2698091037136277 0.9593694420306775 0.07245688952973836 0.1418053716289102 0.360092925011365 0.04858947700838924 0.11413644783011731 1.364777645318242e-07 6.8649380997422345 -0.8042165865739748 down KDSSSVVEWTQAPK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDSSSVVEWTQAPKER 16 2 Q8TC07-2;Q8TC07-3;Q8TC07;F8WCB5 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 15022500.0 5609600.0 5514900.0 3898000.0 True False 7354239.923443681 4692098.416911825 3494672.352256271 1.0 0.6380126927807263 0.4751915070265838 22.810144812865136 -13.999999999999998 0.10790568055837987 2.7534527254206655 0.16729070575734295 0.9997537080518247 0.003442166671839853 12.025390086079408 0.09933153690569119 4.612409891275877 0.2736425485958885 1.0000000000000041e-14 13.999999999999998 -2.5861620196633224 KDSSSVVEWTQAPK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 KDSSSVVEWTQAPKER 16 2 Q8TC07-2;Q8TC07-3;Q8TC07;F8WCB5 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 61809900.0 23216700.0 24805200.0 13788000.0 True False 35221431.26812345 20378518.256087817 11062795.756504929 1.0 0.5785829116640994 0.3140927372397022 25.069950200338884 -8.536861012137914 0.19621234816042166 1.3280380467281954 2.123331993215628e-24 0.9997200735011796 0.004725715203198189 0.17370808555798103 0.050792961909645745 0.1583703536254329 0.1288145785428092 2.904952181571201e-09 8.536861012137914 -1.3280380467281954 down KDSSSVVEWTQAPK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDSSSVVEWTQAPKER 16 2 Q8TC07-2;Q8TC07-3;Q8TC07;F8WCB5 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 13376700.0 5609600.0 3535000.0 4232100.0 True False 7683620.71373996 3378812.011318235 3232565.142835457 1.0 0.4397421654710513 0.42070857780042914 22.873354874388028 KDSSSVVEWTQAPK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KDSSSVVEWTQAPKER 16 2 Q8TC07-2;Q8TC07-3;Q8TC07;F8WCB5 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 77886300.0 23216700.0 43410000.0 11259600.0 True False 30054475.819575787 40994195.33954321 9210468.333252233 1.0 1.363996350681382 0.3064591240434496 24.841076522431333 -6.813767282181286 1.398553329789019 1.1975076760169991 0.2863020043844442 0.8694694586668339 0.15848690028350934 0.2016981004683113 0.7767870004525745 0.08908631949995931 0.20575440900182584 1.5354395316319909e-07 6.813767282181286 -0.911205671632555 down KDSVSK(ub)DIDSSDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDSVSKDIDSSDR 13 2 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 12462100.0 3925100.0 4857900.0 3679100.0 True False 5145844.110722475 4133120.255945887 3298422.024419201 1.0 0.8031957764390182 0.6409875529548648 22.294976321752635 -6.9733398311283805 0.15934624168856448 1.1656487254225059 0.2742332693181408 0.9999980971189136 0.00020241105019670025 0.07523315401940496 0.004915588217158368 0.007554944451264885 0.019512258546221444 1.0633106625553481e-07 6.9733398311283805 -0.891415456104365 KDSVSK(ub)DIDSSDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDSVSKDIDSSDR 13 2 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 13973200.0 4560700.0 5143400.0 4269100.0 True False 4415923.0749009615 7197186.442476668 3150894.6397452415 1.0 1.6298260455178069 0.7135302373481468 22.074283610003317 -6.721740032990534 1.7531925814496518 1.3824653877251118 0.714829761501664 0.5206724796824858 0.2649776626063143 0.35193835579362714 2.1150358603796278 0.11996789585543907 0.3005339465921785 1.8978416219726413e-07 6.721740032990534 -0.6676356262234479 KDSVSK(ub)DIDSSDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KDSVSKDIDSSDR 13 2 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 12041800.0 4560700.0 5160700.0 2320400.0 True False 3792424.1232672757 5132898.284781257 2805584.911682596 1.0 1.3534610365148523 0.7397866959208953 21.854688885437593 -6.750513414180996 1.647787125948132 1.207713511452584 0.7385092504568397 0.6511945793839016 0.148531570792661 0.2991746619870724 1.5983685582594571 0.07119942712231761 0.17277056878898997 1.7761784060979728e-07 6.750513414180996 -0.4692042609957444 KDSVSK(ub)DIDSSDRK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KDSVSKDIDSSDRK 14 3 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 8799200.0 2902500.0 3285400.0 2611300.0 True False 4403304.701173218 2699094.7010526387 2095175.4104265491 1.0 0.6129702312750447 0.47581885711163935 22.070155249088813 -13.999999999999998 0.14453017773343674 2.8575001889255383 0.31500586505804595 0.9995855067804142 0.004518762129224336 11.941345783787563 0.11942112596117319 6.241606066268896 0.14424674093153053 1.0000000000000041e-14 13.999999999999998 -2.5424943238674924 KDSVSK(ub)DIDSSDRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KDSVSKDIDSSDRK 14 3 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 9265800.0 2902500.0 4166500.0 2196800.0 True False 3757343.466828562 3934630.6123521477 1797004.941071488 1.0 1.0471841733631095 0.4782647519281156 21.841281571181263 -6.886776886920329 1.0412977003523265 1.0329723918044513 0.43232057612248437 0.9787524452459136 0.03757693266789168 0.12179567293484507 0.23745457457132166 0.02760656343658831 0.06806928357233862 1.2978458509869e-07 6.886776886920329 -0.6006518156819669 down KDVETTSSVSVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 KDVETTSSVSVKR 13 2 Q96RL1;Q96RL1-2;D6RC40;D6RCQ3;Q96RL1-5;D6RDZ5 Q96RL1 UIMC1 BRCA1-A complex subunit RAP80 1 10999700.0 3147000.0 3407200.0 4445500.0 True False 3047100.2075807047 4767712.728313268 3281090.1878586784 1.0 1.564672115623881 1.0767910355215242 21.539005514902414 -10.222816073658345 3.673956822174849 0.9995726797059401 1.3207315746808261 0.36557393374535796 0.19917661813508927 37504784.17332191 75716073.4609817 200446.23186533432 0.07289118015456278 5.986650796650594e-11 10.222816073658345 0.32115889497488603 KDVETTSSVSVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KDVETTSSVSVKR 13 2 Q96RL1;Q96RL1-2;D6RC40;D6RCQ3;Q96RL1-5;D6RDZ5 Q96RL1 UIMC1 BRCA1-A complex subunit RAP80 1 9261300.0 3147000.0 4189400.0 1924900.0 True False 2616869.935738398 4166830.870669213 2327387.6902679834 1.0 1.5922957475887944 0.889378435849265 21.31941079033669 -6.683343447292409 1.8903478827915134 1.3736375569104693 0.8920053733557891 0.3392794404879872 0.2508502761039914 0.4311734500323374 2.981807193883083 0.10637703580865289 0.2793314368870831 2.0732732900141416e-07 6.683343447292409 -0.4816321835546802 KDVHMPK(ub)HPELADK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDVHMPKHPELADK 14 2 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;P46783;Q9NQ39 A0A1W2PQS6;P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 3045200.0 307100.0 1134400.0 1603700.0 True False 402611.07396063063 965151.941856566 1437764.5077766494 1.0 2.3972314828850028 3.57110025224304 18.619027329081472 -7.08177187459841 0.17547188000228311 6.57156779928192e-14 5.872861469275225 0.9999971431465032 0.0017763587196614804 0.07536989843182386 0.006021777830918857 0.05376608359793218 0.14009029717099616 8.283771778813123e-08 7.08177187459841 5.8728614692751595 KDVHMPK(ub)HPELADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDVHMPKHPELADK 14 2 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;P46783;Q9NQ39 A0A1W2PQS6;P46783 RPS10;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 3111400.0 307100.0 1514200.0 1290100.0 True False 420643.1690654487 1447297.6372102047 985404.9504435196 1.0 3.440677856306795 2.342614888131462 18.682237390604364 -10.610176616273714 6.933240747615833 0.9962494762121908 2.8916463722184256 0.7982643748962904 0.44828232957925696 0.02594726158911321 0.0014588892951395672 0.4333496526272783 0.1446824997382936 2.4537108523507838e-11 10.610176616273714 1.8953968960062348 KDVLIEFYAPWCGHCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KDVLIEFYAPWCGHCK 16 1 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 18003700.0 5742100.0 7542200.0 4719400.0 False True 7527948.706575505 6416933.159265335 4231081.759681446 1.0 0.8524145699425766 0.5620497594498332 22.843825367286843 -6.9603647407058995 0.4302638807285907 1.0115015059523969 0.3918229823249417 0.999783484273513 0.0026770287907421733 0.0795711013282703 0.020651909533468685 0.0037872459587175457 0.024107785175447493 1.0955577093423568e-07 6.9603647407058995 -0.6196785236274551 KDVLIEFYAPWCGHCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KDVLIEFYAPWCGHCK 16 1 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 67264000.0 15897000.0 26236000.0 25131000.0 False True 24116911.22637403 21553980.8171964 20163846.834691387 1.0 0.8937289114215077 0.8360874510596693 24.523541810100376 -13.999999430971943 0.07473788272456323 1.5932062582275792 0.6458522220123115 0.9999074536171185 0.0006530985288353992 12.311343342830758 0.0753536442103379 1.2392593526739732 0.1739776662861949 1.0000013102363791e-14 13.999999430971943 -0.9473540362152677 KDVLIEFYAPWCGHCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KDVLIEFYAPWCGHCK 16 1 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 21869500.0 5742100.0 8395600.0 7731800.0 False True 7865109.544417824 8024654.63146348 5905708.081419439 1.0 1.0202851703647144 0.7508742310666164 22.907035428809735 -6.888753153740539 1.0297654829924077 1.014911505251381 0.7282636123422042 0.9800868719650373 0.017286522775316126 0.12015920052171694 0.22782118772768592 0.012811506772548135 0.031798201065359695 1.2919533912678815e-07 6.888753153740539 -0.2866478929091769 KDVLIEFYAPWCGHCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KDVLIEFYAPWCGHCK 16 1 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 60947000.0 15897000.0 26156000.0 18894000.0 False True 20578979.876717873 24700395.60702813 15455485.868811293 1.0 1.2002730822907817 0.7510326537758526 24.294668132192825 -6.785484400725001 1.514089220795135 1.1125905216333285 0.7468150733541667 0.7864597456681148 0.0849164517797959 0.24213651164238972 1.0965821859236298 0.04415517210607281 0.10373873560106993 1.6387609223207567e-07 6.785484400725001 -0.36577544827916175 KEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK 33 1 Q3ZCM7;A0A075B736;Q5SQY0 Q3ZCM7 TUBB8 Tubulin beta-8 chain 0 29083800.0 12202000.0 12639000.0 4242800.0 False True 15996940.164336083 10753310.466436123 3803795.7558114184 1.0 0.6722104574979771 0.2377827082388969 23.93129264233059 -7.294930831473952 0.3866605803679043 1.0357928930596758 1.5607048127830458e-10 0.9995665763434511 0.006499373275821006 0.1015947096378405 0.030274519930253107 0.011690268054739762 0.05126556121937186 5.070714612987066e-08 7.294930831473952 -1.0357928929036053 down KEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK 33 1 Q3ZCM7;A0A075B736;Q5SQY0 Q3ZCM7 TUBB8 Tubulin beta-8 chain 0 679278000.0 118912000.0 396937000.0 163429000.0 False True 180398197.6316654 326100491.06706357 131127186.51652478 1.0 1.8076704498616507 0.7268763670480705 27.426609683718535 -6.706647824115227 1.806964941092877 1.498219865796502 0.7296349092533738 0.4492735802526786 0.3405307549072587 0.38184338467360995 2.428164879353166 0.1500846960710575 0.3828706491461318 1.9649530407325692e-07 6.706647824115227 -0.7685849565431282 KEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK 33 1 Q3ZCM7;A0A075B736;Q5SQY0 Q3ZCM7 TUBB8 Tubulin beta-8 chain 0 36324800.0 12202000.0 6551800.0 17571000.0 False True 16713409.146651259 6262319.812094709 13421091.686104238 1.0 0.3746883569441871 0.8030134108691597 23.99450270385348 -10.31279069035619 5.616394427927812 1.0000568012698325 0.5888508839067678 0.5512764068015965 0.17486297102772916 0.0001243878471220958 1.5219717993033574e-05 0.16933364300517817 0.05643678122155958 4.86641687732838e-11 10.31279069035619 -0.4112059173630648 KEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK 33 1 Q3ZCM7;A0A075B736;Q5SQY0 Q3ZCM7 TUBB8 Tubulin beta-8 chain 0 57948500.0 25554000.0 4569500.0 27825000.0 False True 21249283.23414651 4544883.196525264 33643078.85173606 1.0 0.21388407065052759 1.5832571141822496 24.34091084230976 -6.751049808722381 1.646303475839588 0.5383353376508341 1.5861445534724474 0.653357588711565 0.33034647700060915 0.29820642866201863 1.5905751567280086 0.1585029684019093 0.3843272306945296 1.7739860128571874e-07 6.751049808722381 1.0478092158216135 KEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEAESCDCLQGFQLTHSLGGGTGSGMGTLLLSK 33 1 Q3ZCM7;A0A075B736;Q5SQY0 Q3ZCM7 TUBB8 Tubulin beta-8 chain 0 351849000.0 118912000.0 136292000.0 96645000.0 False True 153933928.1059491 128707230.38970341 79056601.66144104 1.0 0.836119963762097 0.5135748995311042 27.197736005810984 -6.9603575544943626 0.43036832514168255 1.0127620470653491 0.3245562885933095 0.9997832223605738 0.002975189593294932 0.07957368937075043 0.02066149982933636 0.004207400089996817 0.02677892753967657 1.0955758375362774e-07 6.9603575544943626 -0.6882057584720396 KEAPPMEKPEVVK(ub)THLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEAPPMEKPEVVKTHLR 17 3 P62841;K7EJ78;K7EQJ5;K7EM56;S4R417;K7ELC2;S4R456;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 1 11038800.0 2452500.0 4945600.0 3640700.0 True False 3720621.801766515 4063019.0398508334 2921114.0492245047 1.0 1.092026885915078 0.7851144794769488 21.827112318442484 -6.826322649071624 1.3442759699921256 1.0493113218766552 0.7774598054428573 0.898315784085129 0.04100768809822204 0.18539235249292035 0.6564902712197205 0.023960347459692607 0.0551548496597807 1.4916857842571734e-07 6.826322649071624 -0.2718515164337979 KEAPPMEKPEVVK(ub)THLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEAPPMEKPEVVKTHLR 17 3 P62841;K7EJ78;K7EQJ5;K7EM56;S4R417;K7ELC2;S4R456;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 1 4391910.0 1317700.0 2105900.0 968310.0 True False 1095725.9340077823 2094555.0987115763 1170779.144040413 1.0 1.9115684257380186 1.0684963344420555 20.063455561881554 -10.44554829049783 4.344449547717053 0.9980997201326843 1.4900323800881783 0.31056484389206884 0.3441827400776534 0.006395620176959223 0.0008162269840644944 0.33442961405231375 0.11108450168750124 3.5846908681428076e-11 10.44554829049783 0.49193265995549396 KEAPPMEKPEVVK(ub)THLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEAPPMEKPEVVKTHLR 17 3 P62841;K7EJ78;K7EQJ5;K7EM56;S4R417;K7ELC2;S4R456;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 1 15268100.0 2452500.0 3930300.0 8885300.0 True False 3174809.596002426 3711575.349988634 7268266.57087694 1.0 1.1690702190966282 2.2893551096824223 21.598238640534934 -6.93377273454866 0.7151498697197408 0.9851158649803999 2.5431174454510934 0.9972291257582929 0.030116736374670747 0.0907256159280962 0.0684274989207783 0.028081815418655943 0.09934761076267952 1.1647353737009e-07 6.93377273454866 1.5580015804706935 up KEDEVEEWQHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEDEVEEWQHR 11 1 P15311;E7EQR4 P15311 EZR Ezrin 0 4450080.0 975010.0 360140.0 3114930.0 False True 944058.8412434908 503945.78010528994 2299036.387103056 1.0 0.5338075955535834 2.4352681068849718 19.848517257037297 -6.841889736459787 1.2737496328969296 0.7520414714677639 2.500120085738028 0.9276291601506516 0.21768295427148276 0.16660506831888947 0.5242789131556702 0.1339698887368379 0.30878680357955673 1.4391639229073413e-07 6.841889736459787 1.7480786142702642 up KEDINLSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEDINLSVR 9 1 Q15645;H0YAL2;Q15645-2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 12150500.0 3612900.0 4376000.0 4161600.0 False True 4736546.887373368 3723117.8575143977 3730997.552886024 1.0 0.7860405367123974 0.7877041316390373 22.175404235204628 -9.989012052469276 6.50014655508902 1.0000000571570762 0.7868723341757151 0.9999543029338864 0.0006791597848353471 5.620954022937825e-10 8.74344917437723e-11 0.0006575938103956478 0.00021919787800524768 1.0256234629222234e-10 9.989012052469276 -0.21312772298136107 KEDINLSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEDINLSVR 9 1 Q15645;H0YAL2;Q15645-2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 6495140.0 2221400.0 964040.0 3309700.0 False True 2150882.8729328825 1348986.1994021859 2442790.281128302 1.0 0.6271778981450286 1.135715157654021 21.036497533769158 -6.7101489942383 1.7942326115433294 0.7708449723976705 1.134551726219291 0.46608127265131827 0.1570999592224324 0.374739165521717 2.351642159334357 0.0696692913039912 0.17698999870743437 1.9491757775766155e-07 6.7101489942383 0.36370675382162054 KEDINLSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEDINLSVR 9 1 Q15645;H0YAL2;Q15645-2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 11745700.0 3612900.0 3679900.0 4452900.0 False True 4948686.764951346 3517309.8501980086 3401216.730354196 1.0 0.7107562101341828 0.6872968308366221 22.23861429672752 -13.999999999999998 0.3560015962497904 4.691607080062412 0.684308598777379 0.9997659737972846 0.0021754038095602264 21.27232061765824 0.19251748164454976 59.55359533637015 0.0068593697989513605 1.0000000000000041e-14 13.999999999999998 -4.007298481285033 KEDINLSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEDINLSVR 9 1 Q15645;H0YAL2;Q15645-2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 4868500.0 2221400.0 1588000.0 1059100.0 False True 1847192.524705841 1579445.1288066807 1280552.9132748824 1.0 0.8550517110057068 0.6932427974603276 20.816902809203434 -6.969702613940564 0.2652023801394021 1.042637429682204 0.5008236047975009 0.9999799639402611 0.0005608165880205174 0.07639939063544188 0.009375343111836904 0.0032676485408079615 0.01515087930204248 1.0722532865395223e-07 6.969702613940564 -0.5418138248847032 KEDLVFIFWAPESAPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEDLVFIFWAPESAPLK 17 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 0 7830370.0 2864070.0 3474900.0 1491400.0 False True 3754823.505693336 2956458.465054114 1337084.2345189871 1.0 0.7873761471268401 0.3560977586540627 21.840313665227445 -6.9597684307156795 0.43868487111976107 1.0156338387340735 0.11106180295360492 0.9997615147287159 0.004136803238686785 0.07978393713422707 0.021437718960808694 0.0056769993748847225 0.0357431428265537 1.0970630029675138e-07 6.9597684307156795 -0.9045720357804686 down KEDLVFIFWAPESAPLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEDLVFIFWAPESAPLK 17 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 0 35132800.0 12263000.0 7776800.0 15093000.0 False True 11873717.777426828 10882116.795476243 11139690.519705553 1.0 0.9164877420418631 0.9381805032357483 23.501268391884558 -10.515279621230007 6.180069457232215 1.0000734048766848 0.9273341226388057 0.9373485417925558 0.008856032672844457 8.965971056978262e-06 7.032302494089344e-07 0.008583469795164025 0.002858272254616274 3.05295483020226e-11 10.515279621230007 -0.07273928223787918 KEDLVFIFWAPESAPLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEDLVFIFWAPESAPLK 17 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 0 223043700.0 32521700.0 106181000.0 84341000.0 False True 49337796.55474419 87232170.95406033 67670964.3820265 1.0 1.7680597238928035 1.3715846492443213 25.556189949964534 -10.19272472737551 4.348925471235009 0.9998378082507564 1.5698221865778919 0.7336272521230156 0.16186027169439873 113703110.59992674 65.34897632522897 200133.4499480353 0.05540907619147686 6.416161288228528e-11 10.19272472737551 0.5699843783271354 KEDLVFIFWAPESAPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEDLVFIFWAPESAPLK 17 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 0 7803470.0 2864070.0 2163000.0 2776400.0 False True 3922994.0775815034 2067431.5079155138 2120671.5017528795 1.0 0.5270034741398514 0.540574739552056 21.903523726750336 -9.885857239566102 5.573402558825774 1.0000002877506189 0.533789106861618 0.9993648713992556 0.005540445909836984 1.9802747590448126e-08 3.97292489472165e-09 0.005364516959643112 0.0017881712274270534 1.3005970374906726e-10 9.885857239566102 -0.46621118088900093 KEDLVFIFWAPESAPLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEDLVFIFWAPESAPLK 17 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 0 25904900.0 12263000.0 4749900.0 8892000.0 False True 10197227.843012398 4724311.345918674 10751276.08803726 1.0 0.4632936930163805 1.0543332220829527 23.281673667318834 -6.667672981357429 1.9457999472973149 0.6567329554366206 1.0519111162256354 0.26867994127253747 0.22810541446353202 0.466498023519519 3.402898039782414 0.09445580555010517 0.25311410445652205 2.1494483742972662e-07 6.667672981357429 0.3951781607890148 KEDLVFIFWAPESAPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEDLVFIFWAPESAPLK 17 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 0 129167700.0 32521700.0 46124000.0 50522000.0 False True 42099981.748547256 43557158.85374544 41327514.39949636 1.0 1.0346122977891425 0.9816515989563926 25.327316272056983 -6.7303537458304055 1.7217381766081885 1.020821454630944 0.9816800291856569 0.5609450424579636 0.014549850987907278 0.3356004365610799 1.9491233811080577 0.006696069405278486 0.016610485029972845 1.8605710286001908e-07 6.7303537458304055 -0.03914142544528709 KEDLVFIFWAPESAPLKSK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEDLVFIFWAPESAPLKSK 19 2 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 1 27098000.0 9164600.0 12303100.0 5630300.0 True False 8873674.789448408 17215791.98981894 4155555.5246205605 1.0 1.9400972424964296 0.4683015349584241 23.08110025024348 -6.734164299516422 1.7080599958921328 1.5631014704132753 0.4684898453177721 0.5784751402678114 0.39508124354182644 0.3284760599222311 1.8792420339812965 0.18316272621562082 0.45237654925180715 1.8443175567360259e-07 6.734164299516422 -1.0946116250955031 KEDLVFIFWAPESAPLKSK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEDLVFIFWAPESAPLKSK 19 2 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 1 39227700.0 9986000.0 6520400.0 22721300.0 True False 15149492.074389575 5356783.675882268 18230425.095900424 1.0 0.3535949356967541 1.2033687338415264 23.852766088665977 -6.7033438126177325 1.8189519588272223 0.5999322295878468 1.2010057854310425 0.43347120360688596 0.2726919950503637 0.3885998950188099 2.5018684847962733 0.11949745418485831 0.306053009114273 1.9799589552321674e-07 6.7033438126177325 0.6010735558431958 KEDLVFIFWAPESAPLKSK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEDLVFIFWAPESAPLKSK 19 2 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 1 7068580.0 871980.0 5186600.0 1010000.0 True False 1194374.5703734618 4957438.862207395 771458.8016029411 1.0 4.1506567413414395 0.6459102703113633 20.187823923577508 -6.669757629531524 1.9380564472335704 3.0113621550892633 0.6599648691716264 0.27820934020732824 1.3383815205902592 0.4615634796803139 3.3420553577828813 0.5559815723725076 1.4860080705637175 2.1391555734491687e-07 6.669757629531524 -2.3513972859176366 KEDLYLK(ub)PIQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEDLYLKPIQR 11 2 P13639 P13639 EEF2 Elongation factor 2 1 17221300.0 2695600.0 2727700.0 11798000.0 True False 2610029.6534968377 3816884.8347675847 8707749.867586698 1.0 1.4623913677202247 3.3362647263107994 21.31563476719589 -6.944574640422254 0.6155339416608197 0.9794128281144289 3.9177600846401313 0.9987037810786195 0.03636790218785533 0.08574021895822288 0.04556164584800931 0.03677598790028881 0.15832375768483972 1.136123020054823e-07 6.944574640422254 2.9383472565257023 up KEDLYLK(ub)PIQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEDLYLKPIQR 11 2 P13639 P13639 EEF2 Elongation factor 2 1 59301700.0 7867700.0 14435000.0 36999000.0 True False 11935876.105915776 11858961.468830239 29686131.432762224 1.0 0.9935560124449168 2.4871346828113348 23.50880112985796 -6.905929139714197 0.9230232868466511 0.9475941423841141 2.6642404934835624 0.989292235093678 0.07270033593856981 0.10717156564755738 0.1538296440807638 0.05834778196965718 0.15686397214576084 1.241854914393195e-07 6.905929139714197 1.7166463510994483 up KEDLYLK(ub)PIQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEDLYLKPIQR 11 2 P13639 P13639 EEF2 Elongation factor 2 1 13516800.0 2695600.0 4663800.0 6157400.0 True False 2241510.835327749 4638675.18370818 7444883.871399083 1.0 2.0694413386718793 3.3213686742274917 21.096040042630165 -6.969049536317225 0.279957526995691 0.7240534054363066 4.704903328438508 0.9999739909733001 0.00483812495174652 0.07661232377174086 0.010129307084650534 0.023130250660956597 0.11491736486993066 1.07386691839201e-07 6.969049536317225 3.980849923002202 KEDLYLK(ub)PIQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEDLYLKPIQR 11 2 P13639 P13639 EEF2 Elongation factor 2 1 47250700.0 7867700.0 16264000.0 23119000.0 True False 10184892.74555283 15358894.102794992 18911579.22097219 1.0 1.5080074465684832 1.8568265462814828 23.27992745195041 -7.828719414374525 0.09987503953540011 1.9899766572475324e-19 3.0743033422228687 0.9999930201244642 0.0009294305200217427 0.1310978690205411 0.013912903948997156 0.1837122741870108 0.22577623258574672 1.4834762084583086e-08 7.828719414374525 3.0743033422228687 KEDLYLKPIQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEDLYLKPIQR 11 2 P13639 P13639 EEF2 Elongation factor 2 0 35101030.0 948030.0 22877000.0 11276000.0 False True 1242876.5107355807 19463840.773847565 10109267.687029688 1.0 15.66031750196014 8.133766789949748 20.245251530075205 -9.863480994101467 10.388865674988466 1.0003023563531244 11.897042145954943 0.7364874341673133 3.0727014662265 0.0 0.0 2.975130532358511 0.9917101331333378 1.3693643141577516e-10 9.863480994101467 10.896739789601819 KEDLYLKPIQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEDLYLKPIQR 11 2 P13639 P13639 EEF2 Elongation factor 2 0 33162200.0 10321000.0 2345200.0 20496000.0 False True 9993365.504429761 3281650.5900564324 15127482.733179947 1.0 0.3283829245114446 1.5137525717911933 23.252539191173074 -6.752972447758789 1.6387412067678857 0.6065148933993091 1.5166742684583092 0.6617724845226782 0.28226865650290794 0.2948530488344983 1.5587530955576658 0.1360156836488556 0.32919877606770487 1.7661498641165063e-07 6.752972447758789 0.9101593750590001 KEDLYLKPIQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEDLYLKPIQR 11 2 P13639 P13639 EEF2 Elongation factor 2 0 24574030.0 948030.0 12205000.0 11421000.0 False True 1298542.310547436 11665742.743462242 8723595.022878425 1.0 8.983721707569336 6.717990589925988 20.308461591598096 -9.994671441395665 8.396778471080594 0.9999999752384914 7.8508561487476625 0.9241862775784688 0.9249808554286743 4.326283570809788e-07 5.0859932386761946e-08 0.8956088621587751 0.29853628738632876 1.0123450382156239e-10 9.994671441395665 6.850856173509171 KEDMTYAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEDMTYAVR 9 1 J3KTL2;Q07955;Q07955-3;Q07955-2;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 11800100.0 2617600.0 1285500.0 7897000.0 False True 2534505.7208017977 1798806.853793938 5828538.795078165 1.0 0.7097268864024819 2.299674744168378 21.273272989658377 -6.859625618036614 1.187742299440666 0.842677960358071 2.3760726073368588 0.9531684958956639 0.14960635556219762 0.1471914587286094 0.3948009420309693 0.0982602610253192 0.2292552638185325 1.3815747328350463e-07 6.859625618036614 1.5333946469787878 up KEEELQAALAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEEELQAALAR 11 1 P35579;P35749-2;P35749;P35749-3;P35749-4;A0A0C4DFM8;Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4 P35579;Q7Z406 MYH9;MYH11;MYH14 Myosin-9;Myosin-11;Myosin-14 0 20237800.0 1022200.0 11702600.0 7513000.0 False True 1340114.0989988823 9956617.696377523 6735626.829784861 1.0 7.429679087635527 5.0261592164552535 20.353924408105808 -9.420165045910654 9.8507368873807 1.0000000004230307 6.227919152048157 0.8631661973045975 0.9812328785052928 0.0 0.0 0.9500746493005315 0.31669154976684377 3.8004493953836564e-10 9.420165045910654 5.227919151625127 KEEELQAALAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEEELQAALAR 11 1 P35579;P35749-2;P35749;P35749-3;P35749-4;A0A0C4DFM8;Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4 P35579;Q7Z406 MYH9;MYH11;MYH14 Myosin-9;Myosin-11;Myosin-14 0 18166700.0 3891200.0 1254000.0 13021500.0 False True 3767675.985935189 1754728.7395236087 9610778.513373468 1.0 0.4657323894289336 2.5508505904570087 21.845243470160213 -6.838719568903193 1.288193654662652 0.7156992750507303 2.617765494943688 0.9222443749469716 0.24659170238397987 0.17030620410558125 0.549511139157297 0.1501256959264042 0.34577679215560336 1.4497076514794505e-07 6.838719568903193 1.9020662198929579 up KEEELQAALAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEEELQAALAR 11 1 P35579;P35749-2;P35749;P35749-3;P35749-4;A0A0C4DFM8;Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4 P35579;Q7Z406 MYH9;MYH11;MYH14 Myosin-9;Myosin-11;Myosin-14 0 14214300.0 1022200.0 6713100.0 6479000.0 False True 1400134.96391632 6416493.044746938 4948793.639193521 1.0 4.582767526067169 3.5345118625930474 20.4171344696287 -9.6828009974142 8.289406791393963 1.000006303599137 4.058639693552323 0.9190394908150852 0.42794858259786206 0.0 0.0 0.4143594271772507 0.1381198111172161 2.075864502994814e-10 9.6828009974142 3.0586333899531857 KEEIIK(ub)TLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEEIIKTLSK 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 21674900.0 5647200.0 9378200.0 6649500.0 True False 7403533.887562599 7979009.11593728 5961473.526507973 1.0 1.0777298027015771 0.8052199958891005 22.819782638051052 -6.83046556367093 1.3257398879076197 1.0415214473654553 0.7978125154703959 0.9068156288211063 0.03498948670812879 0.18023998324234586 0.6193758792689908 0.020720750788849898 0.04768591477605257 1.4775236336028367e-07 6.83046556367093 -0.24370893189505938 KEEIIK(ub)TLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEEIIKTLSK 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 36201000.0 11872000.0 11080000.0 13249000.0 True False 11495129.858404255 15504301.781436702 9778689.438519761 1.0 1.348771346858799 0.8506810761576931 23.454519428224796 -6.718453367513345 1.764686685663734 1.2125335152942054 0.8515131048016272 0.5053148032562269 0.14679244042123119 0.35832152755861135 2.179862171288117 0.06606766284724264 0.16616915807741794 1.9122586428667336e-07 6.718453367513345 -0.36102041049257816 KEEIIK(ub)TLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEEIIKTLSK 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 40483700.0 21273000.0 7225700.0 11985000.0 True False 32272696.26461941 5936217.380348217 9616159.496787896 1.0 0.18393930682687018 0.29796579182415883 24.943810778915783 -10.780435648681063 7.209510614560818 1.019829757561746 0.24095254932551463 0.9833564538607235 0.046551117567746415 0.013735665039391444 0.0004183167058510059 0.04172633757657349 0.015024308590602116 1.657922980371859e-11 10.780435648681063 -0.7788772082362314 KEEIIK(ub)TLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEEIIKTLSK 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 20620700.0 5647200.0 9155300.0 5818200.0 True False 7735122.4498417545 8750788.573471515 4444060.989590331 1.0 1.1313057589218305 0.5745301407195238 22.882992699573943 -6.844537510796302 1.261215985269021 1.0698645894019638 0.5545168293898799 0.931966227552516 0.06198492447564169 0.16356796233922263 0.5034433460046949 0.038506386014023015 0.08884641670837741 1.430416427842214e-07 6.844537510796302 -0.5153477600120839 KEEIIK(ub)TLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEEIIKTLSK 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 38770700.0 11872000.0 22541000.0 4357700.0 True False 9872094.018775443 22419567.15896182 5268874.922271701 1.0 2.2710042181853933 0.5337140136885836 23.234924703659072 -6.710581929061432 1.7930127757360375 1.780921544375384 0.5377089159593542 0.46789063856613133 0.5355464465926709 0.37392261599229004 2.3436656283665056 0.23765238886586187 0.6033497121539907 1.947233672315515e-07 6.710581929061432 -1.2432126284160299 KEEIIK(ub)TLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEEIIKTLSK 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 41153200.0 21273000.0 13045000.0 6835200.0 True False 27538317.85352075 12319034.282523388 5591263.73507457 1.0 0.44734156777656664 0.20303577599819633 24.714937101008232 -9.93881084264583 0.20628735726607247 1.6033767782089217 2.6393403341361547e-15 0.9993855629383368 0.00826372139966401 1.4277228764830954 0.09275846023308736 0.6282047765490278 0.13801107928088194 1.1513017302660032e-10 9.93881084264583 -1.603376778208919 KEELSEEGYLAK(ub)VK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEELSEEGYLAKVK 14 2 P26358;P26358-2;K7EJL0 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 7085300.0 2564600.0 2834800.0 1685900.0 True False 3362215.435621729 2411858.8899638555 1511459.2402947291 1.0 0.7173421620788744 0.44954265103932445 21.68098073826033 -6.971779526484584 0.21140541874384208 1.1377189599173414 0.021678062865075294 0.999993135492931 0.0005888227530501754 0.07572938844377669 0.006924758234103742 0.007930596259452551 0.02766100408936915 1.0671377258461661e-07 6.971779526484584 -1.1160408970522662 down KEELSEEGYLAK(ub)VK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEELSEEGYLAKVK 14 2 P26358;P26358-2;K7EJL0 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 4170700.0 1877100.0 2293600.0 0.0 True False 1817512.4879725915 3209446.4409659896 0.0 1.0 1.76584560612625 0.0 20.793533846137123 -6.799526242312546 1.5283288716077734 1.4280780489275535 8.001669493097375e-17 0.7970949572475207 0.32568107807450997 0.23037466074277793 1.0735138135737463 0.16946190664891328 0.38244477501487695 1.5866230441073677e-07 6.799526242312546 -1.4280780489275535 KEELSEEGYLAK(ub)VK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEELSEEGYLAKVK 14 2 P26358;P26358-2;K7EJL0 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 3973800.0 1877100.0 2096700.0 0.0 True False 1560891.8196296636 2085404.6609376334 0.0 1.0 1.3360340766167993 0.0 20.5739391215714 -6.873206550838662 1.3545220129470763 1.176023812216658 4.321073554169612e-20 0.9235276414777314 0.15691813252687642 0.15424914047325888 0.5690004131920742 0.09378144583871652 0.19262450169055198 1.339039687502604e-07 6.873206550838662 -1.176023812216658 down KEELSEEGYLAK(ub)VK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEELSEEGYLAKVK 14 2 P26358;P26358-2;K7EJL0 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 15100500.0 2653300.0 5095000.0 7352200.0 True False 3434749.1543621784 4811458.771135053 6014175.039942549 1.0 1.4008180961408592 1.7509794077114669 21.711773309714783 -6.972709793040414 0.18217976731258637 0.7370023260852673 2.4242848582404886 0.9999965315710956 0.0005713809128400625 0.07543279593034827 0.005759518722087868 0.013227688618002722 0.03903882936129788 1.0648543441267276e-07 6.972709793040414 1.6872825321552214 KEELTLEGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEELTLEGIR 10 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 23920900.0 1380500.0 8064400.0 14476000.0 False True 1809848.8687810157 6861222.954784989 12978162.383597188 1.0 3.7910474587893166 7.170854211898006 20.787437799581028 -6.96857010735017 0.29031372027857394 0.3420816663345297 10.724287992566232 0.9999689824605185 0.014051775297239461 0.07676945132417393 0.010682334478178684 0.0589475573787826 0.3063849290488313 1.075053042572114e-07 6.96857010735017 10.382206326231703 KEELTLEGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEELTLEGIR 10 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 19130900.0 1380500.0 4481400.0 13269000.0 False True 1890908.1566097406 4283396.92999195 10135135.483633097 1.0 2.2652591110885925 5.3599300675738 20.85064786110392 -6.955928970460206 0.4894472646692732 0.9319350153121665 6.824359254717127 0.9995881516011708 0.03716690478717079 0.08118873272035516 0.026758477742413193 0.0445038295669814 0.25523939839897847 1.1068047888247166e-07 6.955928970460206 5.89242423940496 KEENLADWYSQVITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEENLADWYSQVITK 15 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 11932000.0 1680200.0 5574200.0 4677600.0 False True 2202758.4710799474 4742551.088061422 4193606.822707532 1.0 2.1530054930336004 1.9037978415543355 21.070879883846345 -10.105855507628618 4.482166636495935 0.9999214341414723 2.0284016669758502 0.9578166695257311 0.1017385986664563 47239942.344024636 33597851.74704046 55848.21422096731 0.03723251607888588 7.836903378585821e-11 10.105855507628618 1.028480232834378 KEENLADWYSQVITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEENLADWYSQVITK 15 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 8750300.0 2408100.0 2436600.0 3905600.0 False True 2331656.1836272976 3409547.086701135 2882606.194511495 1.0 1.4622855250455453 1.2362912743109058 21.15292363970445 -10.1249344344666 4.398795771674537 0.9999517956631436 1.3492883996984453 0.7610525633193892 0.09226176658389383 13848201.83312189 15937562.776241535 5345.344462117572 0.03158365537200237 7.500074295723098e-11 10.1249344344666 0.34933660403530165 KEESISLMK(ub)ETEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEESISLMKETEGK 14 2 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 16710500.0 6106300.0 6464800.0 4139400.0 True False 8005418.433493321 5500277.039593025 3711094.5959285866 1.0 0.6870692750526061 0.4635728446625591 22.932545381953137 -7.807222379943054 0.14964237239234554 1.3326247779034972 1.7566720335169698e-11 0.9999662712852881 0.001277712931557674 0.12825451903175417 0.02059300800388837 0.06971605702519157 0.09670875000214513 1.5587541403477156e-08 7.807222379943054 -1.3326247778859306 down KEESISLMK(ub)ETEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEESISLMKETEGK 14 2 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 17151000.0 6028900.0 5740800.0 5381300.0 True False 5837515.869553019 8033131.3778765 3971776.09446044 1.0 1.3761215485126552 0.6803880594442924 22.476923136184045 -6.75983603569484 1.6127645654372813 1.2185069023952755 0.6778357435275955 0.690474033020561 0.158195025826723 0.283166082260748 1.4515156743412803 0.0773899527094509 0.18603433630938987 1.7384570450079377e-07 6.75983603569484 -0.54067115886768 KEESISLMK(ub)ETEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEESISLMKETEGK 14 2 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 19345100.0 6028900.0 10722000.0 2594200.0 True False 5013297.475555534 10664238.457849646 3136635.22577443 1.0 2.1271904389970238 0.625663097206665 22.25732841161832 -6.705816796363446 1.810022759845135 1.6959124887645896 0.6295961085630464 0.44524744337057387 0.4753149044003032 0.38355317037133996 2.446780589248458 0.20918185988619356 0.5341520992028324 1.9687166018392317e-07 6.705816796363446 -1.0663163802015432 KEESISLMK(ub)ETEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEESISLMKETEGK 14 2 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 24621900.0 12195000.0 7629100.0 4797800.0 True False 15786667.899388196 7204533.878482115 3924649.6295852032 1.0 0.45636824213938926 0.24860532029924445 23.912203357111878 -13.043044505367387 0.14574180069520937 2.984104586080005 1.0033867669616515e-19 0.9995964939335187 0.006363827166536384 8.423307389890603 0.11136393675187664 4.9889721542432355 0.21181366338880514 9.05639788535903e-14 13.043044505367387 -2.984104586080005 KEESISLMK(ub)ETEGKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEESISLMKETEGKR 15 3 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 7970000.0 1873300.0 4255600.0 1841100.0 True False 2455914.4410630055 3620681.068198873 1650600.6330782513 1.0 1.4742700346807343 0.6720920751472977 21.227828870421437 -6.746526109039301 1.6627933156403412 1.2800405575069431 0.6709212164807078 0.6338267217064794 0.1992667211599695 0.3061560184137303 1.6643521595002526 0.09471390887719176 0.2307764399825093 1.7925607834466196e-07 6.746526109039301 -0.6091193410262353 KEESISLMK(ub)ETEGKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEESISLMKETEGKR 15 3 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 6895200.0 2548800.0 1777600.0 2568800.0 True False 2467889.7391425855 2487404.9500615364 1895954.2176518657 1.0 1.0079076510629406 0.7682491594258071 21.23484650824194 -6.899270623660074 0.9658833090185677 1.010164513964948 0.7434636905041473 0.9861994662579958 0.013058492699607354 0.11194361043978573 0.1804702315958407 0.010153803328986943 0.026322652115809905 1.2610414918752006e-07 6.899270623660074 -0.2667008234608007 KEESISLMK(ub)ETEGKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEESISLMKETEGKR 15 3 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 30608600.0 12707000.0 9600300.0 8301300.0 True False 19277448.00613543 7887051.457513732 6660544.416410961 1.0 0.4091335873401667 0.3455096553387726 24.200410741060463 -13.999999999999998 0.3147571105427199 6.873303568558059 0.33212607969144564 0.9996824001903312 0.0052515931670880575 17.615469625508165 0.1786945485897633 67.93782350749707 0.0216269041717004 1.0000000000000041e-14 13.999999999999998 -6.541177488866613 KEESISLMK(ub)ETEGKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEESISLMKETEGKR 15 3 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 7102800.0 1873300.0 2929100.0 2300400.0 True False 2565909.6340289963 2799682.676761593 1757092.8982251575 1.0 1.0911072781489681 0.6847836240694755 21.29103893194433 -6.847826035839402 1.245485555908337 1.048543011318431 0.6692043240530332 0.9370910357910734 0.0436642491145319 0.15986229464178336 0.4782927637336164 0.027447251107307388 0.06343455521774437 1.4196260635668807e-07 6.847826035839402 -0.3793386872653979 KEESISLMK(ub)ETEGKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEESISLMKETEGKR 15 3 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 31691200.0 12707000.0 10771000.0 8213200.0 True False 16449461.992417067 10171584.381530045 6718481.874548578 1.0 0.6183536206970768 0.4084317090519853 23.971537063152912 -10.173243821968246 0.12536363839778963 1.7872039462797609 1.3397492343930022e-17 0.9998396284802115 0.003101040567389836 1.8307887343358336 0.061083691020136034 0.6909415683492603 0.23474908706142678 6.710520045775959e-11 10.173243821968246 -1.7872039462797609 KEETAK(ub)LIEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEETAKLIEK 10 2 P13639 P13639 EEF2 Elongation factor 2 1 9943100.0 3443800.0 4487800.0 2011500.0 True False 4514855.149806643 3818237.7333073826 1803369.2756704707 1.0 0.8457054781637692 0.39943015131896387 22.10624827175725 -6.95226912010351 0.5333508351067914 1.0068733935493728 0.21788656935198988 0.9993675362069592 0.006404328776570451 0.0825871694270803 0.03228892348606498 0.007110184764353984 0.03692120992665068 1.1161713733564179e-07 6.95226912010351 -0.7889868241973829 down KEETAK(ub)LIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KEETAKLIEK 10 2 P13639 P13639 EEF2 Elongation factor 2 1 22291600.0 5563900.0 8587500.0 8140200.0 True False 8440843.075575415 7054993.530556258 6531285.902023588 1.0 0.8358162173362425 0.7737717480997416 23.008955672546605 -13.999999999999998 0.1349728750426589 1.7815095370414138 0.6921309160678439 0.9996237110347009 0.0018514189972279086 11.932218503810573 0.11471125836829374 2.4639543249383653 0.07276734938179892 1.0000000000000041e-14 13.999999999999998 -1.0893786209735699 KEETAK(ub)LIEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEETAKLIEK 10 2 P13639 P13639 EEF2 Elongation factor 2 1 9705700.0 3443800.0 2890900.0 3371000.0 True False 4717065.925195677 2763170.479072101 2574839.2279242743 1.0 0.5857816114701592 0.5458561039333921 22.16945833328014 -13.999999999999998 0.33082372204625027 5.531486646436411 0.5388533306223076 0.9997165488455719 0.0034568138222496954 18.89339853905266 0.1839728160191416 59.59536968727837 0.01275515095403105 1.0000000000000041e-14 13.999999999999998 -4.992633315814103 KEETAK(ub)LIEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEETAKLIEK 10 2 P13639 P13639 EEF2 Elongation factor 2 1 21013600.0 5563900.0 6028100.0 9421600.0 True False 7202578.230865603 5692630.935874222 7706965.473779644 1.0 0.7903601673466424 1.070028707324908 22.780081994639055 -6.706101643430468 1.8089661460311421 0.8706049487398728 1.069301437259151 0.4465370995462188 0.08839750868193441 0.3830162272998952 2.440679275063987 0.03892241014611464 0.09935647627288972 1.967425774281265e-07 6.706101643430468 0.19869648851927812 KEEVK(ub)NVAELPTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEEVKNVAELPTK 13 2 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 4461100.0 1138500.0 1832500.0 1490100.0 True False 1492584.5252496833 1559098.143029054 1335918.7460485047 1.0 1.0445627143080851 0.8950372481082965 20.509381203129582 -6.826840693940352 1.341985152490971 1.0238682977521434 0.8912676889933209 0.8994012906358698 0.019880919393575232 0.18474411333820112 0.651798820418495 0.011635460853095714 0.026782292798402687 1.4899074990356724e-07 6.826840693940352 -0.1326006087588225 KEEVK(ub)NVAELPTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEEVKNVAELPTK 13 2 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 6340900.0 1566300.0 3352400.0 1422200.0 True False 1302447.8488551173 3334339.955800697 1719575.4444901722 1.0 2.560056403587799 1.3202643361127433 20.312794176219988 -6.588766437217211 2.2343909418609083 2.05669233053621 1.3238599981844061 0.0 0.6762374013914847 0.6729843426990589 6.332839881050848 0.25289036620539246 0.7536421272266013 2.577707070474346e-07 6.588766437217211 -0.7328323323518038 KEEVK(ub)NVAELPTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KEEVKNVAELPTK 13 2 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 11208800.0 3273400.0 3635300.0 4300100.0 True False 4237480.828360586 3432992.3593144743 3517525.9227519576 1.0 0.8101493548568205 0.8300983686368281 22.01477541040108 -10.060251154078907 4.879249788619337 1.000004674165359 0.8201238617449396 0.9908595134035147 0.008144150778635853 4.1411245915421015e-07 7.97407387007699e-08 0.007885744989451382 0.002628513360294145 8.704600541556511e-11 10.060251154078907 -0.17988081242041942 KEGGLGPLNIPLLADVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEGGLGPLNIPLLADVTR 18 1 P32119;A6NIW5 P32119 PRDX2 Peroxiredoxin-2 0 9776330.0 843730.0 7404300.0 1528300.0 False True 1106138.200692944 6299607.301735344 1370166.1764887802 1.0 5.695135831841748 1.2386934793775632 20.077100216197426 -6.6338772910228725 2.0659107573293674 4.084378890472813 1.2567081941070744 0.13175432105806661 2.011980511488294 0.5490114685903086 4.470127336546428 0.7950645421020622 2.22906532891982 2.3233931733963667e-07 6.6338772910228725 -2.8276706963657388 KEGGLGPLNIPLLADVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEGGLGPLNIPLLADVTR 18 1 P32119;A6NIW5 P32119 PRDX2 Peroxiredoxin-2 0 17182700.0 9335200.0 2889000.0 4958500.0 False True 9038859.185830139 4042592.7659359705 3659720.098188564 1.0 0.4472459060180275 0.4048873893207411 23.10770926776065 -13.999999999999998 0.36431363330508665 8.429746306945129 0.4000979328669877 0.9997810074608927 0.004011942613252156 22.169960342590617 0.19542042747447994 128.3170040686229 0.012053410110483557 1.0000000000000041e-14 13.999999999999998 -8.02964837407814 KEGGLGPLNIPLLADVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEGGLGPLNIPLLADVTR 18 1 P32119;A6NIW5 P32119 PRDX2 Peroxiredoxin-2 0 26245930.0 843730.0 5539200.0 19863000.0 False True 1155679.7819459175 5294459.828315119 15171768.491325973 1.0 4.581251581126029 13.128003732815989 20.140310277720317 -6.95644970683083 0.4828816032198737 0.8003149183226496 17.267014062719383 0.9996150003283887 0.09982753737265179 0.08099468979761164 0.026009758160043854 0.12121992988628831 0.7049728645688812 1.1054784811339963e-07 6.95644970683083 16.466699144396735 KEGGLGPLNIPLLADVTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEGGLGPLNIPLLADVTR 18 1 P32119;A6NIW5 P32119 PRDX2 Peroxiredoxin-2 0 13222200.0 9335200.0 1870800.0 2016200.0 False True 7762632.419480502 1860721.6290752734 2437778.098144478 1.0 0.2397024010058431 0.3140401305138214 22.888114543194927 -10.312043430579852 5.692768965317555 1.0000876673362757 0.27687126583690624 0.9921364252339597 0.030348250988617532 3.3771396046978096e-05 4.08113917240598e-06 0.029388090897672307 0.009794855888783574 4.8747973842168834e-11 10.312043430579852 -0.7232164014993695 KEGTGSTATSSSSTAGAAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEGTGSTATSSSSTAGAAGK 20 1 A0A087WZK9;B3KS98;O15372;E5RGU4;E5RHC7;E5RH59;E5RFW7;E5RFH0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 0 3180340.0 1583400.0 442140.0 1154800.0 False True 1533135.8337093412 618688.8077296398 852323.2367425935 1.0 0.40354467890346996 0.555934587139903 20.548054092764055 -10.384786276369756 8.93656870885218 1.0000016531833837 0.4797396330220163 0.939542703791339 0.06221291952146873 2.0492531837239037e-06 1.4102152610379833e-07 0.0602375923246245 0.020079133435465885 4.123003691371365e-11 10.384786276369756 -0.5202620201613675 KELEQVCNPIISGLYQGAGGPGPGGFGAQGPK(ub)GGSGSGPTIEEVD ddPTM_RPMI8226_Bortezomib_8h_R1 1 KELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD 45 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 98397000.0 22601000.0 40722000.0 35074000.0 True False 34287369.354424074 33454840.937561803 28141608.52651968 1.0 0.9757190932831116 0.8207572950733996 25.031173884177292 -6.934546412743262 0.7085131760282363 1.0020065517424923 0.7849221705923505 0.9973582265773324 0.004080703552668026 0.0903455797350646 0.06662097044046848 0.0038238910461826847 0.013687924298647148 1.1626622914692263e-07 6.934546412743262 -0.21708438115014184 KELEQVCNPIISGLYQGAGGPGPGGFGAQGPK(ub)GGSGSGPTIEEVD ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD 45 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 88091000.0 22601000.0 39338000.0 26152000.0 True False 29257440.03231432 37148805.719118826 21392604.3421802 1.0 1.2697216734645491 0.7311851043205575 24.80230020626974 -6.770546897132095 1.5725424712845892 1.1545966585825747 0.7281053998610706 0.732598534740518 0.11368984390907275 0.26553762674349934 1.2960178945834926 0.05698587533430911 0.13557199352551716 1.696106438932274e-07 6.770546897132095 -0.42649125872150406 KELINIK(ub)GISEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KELINIKGISEAK 13 2 E9PNT5;Q06609-3;Q06609;E9PJ30;Q06609-4;H0YD61;Q9NZG9;E9PI54;Q06609-2 E9PNT5 RAD51 DNA repair protein RAD51 homolog 1 1 7179400.0 3164800.0 4014600.0 0.0 True False 4801232.9778718315 3298163.2637870307 0.0 1.0 0.6869408918475264 0.0 22.194973513207632 -7.455170742322897 0.7347159611216614 0.9917728178625577 1.785334413054618e-17 0.9872019127438545 0.047248324442340534 0.1168172422303596 0.14071414776859273 0.04133750757231829 0.07453434783703616 3.506140034032655e-08 7.455170742322897 -0.9917728178625577 down KELINIK(ub)GISEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KELINIKGISEAK 13 2 E9PNT5;Q06609-3;Q06609;E9PJ30;Q06609-4;H0YD61;Q9NZG9;E9PI54;Q06609-2 E9PNT5 RAD51 DNA repair protein RAD51 homolog 1 1 19446000.0 3164800.0 6564700.0 9716500.0 True False 4096895.9875345477 6199368.674164917 7948196.699709161 1.0 1.513186737722284 1.9400533291283946 21.96609983530008 -6.97324251689258 0.1630753286635636 0.5857607044348501 2.8788372506167597 0.9999978922413313 0.0005579220338395529 0.0752638611728052 0.005049819092389283 0.019188212607893607 0.05065522559785305 1.0635489498530164e-07 6.97324251689258 2.2930765461819096 KELK(ub)ELIQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KELKELIQK 9 2 R4GN98;P06703 R4GN98 S100A6 Protein S100;Protein S100-A6 1 3669430.0 228230.0 1506600.0 1934600.0 True False 346241.59584798047 1237735.4588804736 1552225.4620346958 1.0 3.5747740124901375 4.483070435928242 18.401419528196218 -9.325439936371463 0.33771429181818224 3.917798799689633e-26 4.747735037263454 0.9983864390613808 0.05925800159287213 0.7112442363976549 0.13118030083755278 1.1472171068437602 0.27545200978646384 4.726722037075363e-10 9.325439936371463 4.747735037263454 KELNSNHDGADETSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KELNSNHDGADETSEK 16 1 Q01105-2 Q01105-2 SET Protein SET 0 3561720.0 923090.0 338030.0 2300600.0 False True 893787.0132239192 473007.14180316264 1698003.8434793989 1.0 0.5292168433920407 1.899785763673879 19.769571556881118 -6.813977095004106 1.3977193392469227 0.7446021493030206 1.9260135649307744 0.8699576188041998 0.20504353585480575 0.2014324640050994 0.7748016274641173 0.11532372518088564 0.2663236849450674 1.5346979217107903e-07 6.813977095004106 1.1814114156277538 KENLK(ub)AAQEEYVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KENLKAAQEEYVK 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 63453000.0 14490000.0 30349000.0 18614000.0 True False 18996530.321359627 25821047.499475468 16688001.838096008 1.0 1.3592507190874945 0.878476308872683 24.179232601437253 -6.706752738732709 1.8075321049281232 1.2215981697725404 0.8797465635017807 0.44935279562412833 0.15146613123897915 0.38162462064352143 2.4285769657201386 0.06674813987860118 0.17019496648309232 1.9644784148585862e-07 6.706752738732709 -0.3418516062707597 KENLK(ub)AAQEEYVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KENLKAAQEEYVK 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 158861000.0 36740000.0 57446000.0 64675000.0 True False 35573708.81045928 80384487.37693243 47734677.29158925 1.0 2.259660014794353 1.3418527021156266 25.084308057602705 -10.172063128333036 4.730329030690598 0.999902929671742 1.800756358460051 0.5037050799575931 0.3746932663936965 46705357.22636703 100434916.02272817 30795.11360784733 0.128267464745755 6.728788406115226e-11 10.172063128333036 0.800853428788309 KENLK(ub)AAQEEYVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KENLKAAQEEYVK 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 90964000.0 27552000.0 35498000.0 27914000.0 True False 41798398.32100754 29163104.55286012 22396785.664859146 1.0 0.6977086616786217 0.5358288012103731 25.316944324732727 -13.999999999867839 0.07725466830142495 2.658553024944039 0.026873400836317403 0.999897764337842 0.0019450298334801502 12.285947752829065 0.07739751543435151 3.5281315246762714 0.4638525369418841 1.0000000003043118e-14 13.999999999867839 -2.631679624107721 KENLK(ub)AAQEEYVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KENLKAAQEEYVK 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 55539000.0 14490000.0 20193000.0 20856000.0 True False 19847344.577526394 19300806.490678668 15930242.342802929 1.0 0.9724629113626322 0.8026384728988436 24.242442662960144 -6.935259889424429 0.7023107861443655 1.0021491502115494 0.7625983426925396 0.9974742246783477 0.004386115886492883 0.08999788247147664 0.06497335654777614 0.004129298033403296 0.014946952307691108 1.1607537905655537e-07 6.935259889424429 -0.2395508075190098 KENLK(ub)AAQEEYVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KENLKAAQEEYVK 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 123740000.0 36740000.0 63496000.0 23504000.0 True False 30550937.85796917 63153934.44503086 28418577.72978271 1.0 2.0671684364857312 0.9302031205032145 24.86471333303698 -6.660474499093907 1.9715687418089398 1.6866638401257537 0.9349729823164202 0.23752157715086863 0.4543261446224278 0.48328792160130735 3.6119166334618678 0.18616003836063535 0.5035554850978281 2.1853726366100656e-07 6.660474499093907 -0.7516908578093334 KENLK(ub)AAQEEYVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KENLKAAQEEYVK 13 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 83683000.0 27552000.0 37712000.0 18419000.0 True False 35666607.131114714 35613294.04848773 15066930.994899714 1.0 0.9985052381789219 0.4224380227564644 25.088070646825177 -6.907467356859609 0.9128074634703299 1.019296090058693 0.3518868829646234 0.9899302432066075 0.027286043026392114 0.10611675769806227 0.14802758660757637 0.022063394946512997 0.05988753964035974 1.2374641987143775e-07 6.907467356859609 -0.6674092070940696 down KENLK(ub)AAQEEYVKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KENLKAAQEEYVKR 14 3 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 19951700.0 4621000.0 8429200.0 6901500.0 True False 4474308.884407512 11795023.517697303 5093790.109438012 1.0 2.6361665728536754 1.138452941232852 22.093233425770524 -6.625173173722229 2.0984938615200828 2.0817089913498825 1.1444037119118577 0.10029281049765892 0.7026912123028302 0.57160963755403 4.7905055406693355 0.2745164357258355 0.7784705770936732 2.3704283154605285e-07 6.625173173722229 -0.9373052794380248 KENLK(ub)AAQEEYVKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KENLKAAQEEYVKR 14 3 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 76068000.0 17274000.0 29554000.0 29240000.0 True False 26205920.89855851 24279857.79354409 23460701.18365271 1.0 0.9265027505627416 0.8952442951525201 24.643389471620473 -13.999999962845731 0.11685270737024006 1.3512779120583296 0.8431706041635032 0.999708497781793 0.0007496702237298088 11.976824502175825 0.10478330379493822 0.9813354647726601 0.04620695345585571 1.0000000855508696e-14 13.999999962845731 -0.5081073078948264 KENLK(ub)AAQEEYVKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KENLKAAQEEYVKR 14 3 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 21855400.0 4621000.0 13037000.0 4197400.0 True False 3842566.245010213 12966767.093358098 5075056.933415153 1.0 3.3745071045154185 1.3207467639641601 21.8736387012048 -6.610901463624313 2.1498299387392503 2.585395754865101 1.3280430996155543 0.05337052963597455 1.023478376814205 0.6101498050864175 5.344829464542106 0.39290394346387275 1.136455075688887 2.4496189689017666e-07 6.610901463624313 -1.2573526552495469 KENLK(ub)AAQEEYVKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KENLKAAQEEYVKR 14 3 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 65585120.0 17274000.0 32762120.0 15549000.0 True False 22361533.521445822 30938879.22178191 12719241.546212927 1.0 1.383575915851656 0.5688000572060293 24.414515793712923 -6.778690582874362 1.5410145372575232 1.2175588204228167 0.5626133417694524 0.762719817913861 0.16212142461374665 0.2526117912925841 1.184804205977472 0.08286969198561427 0.19574936769196774 1.6645981863907185e-07 6.778690582874362 -0.6549454786533643 KENPLQFK(ub)FR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KENPLQFKFR 10 2 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 A0A2R8Y5S7;P15311 RDX;EZR Radixin;Ezrin 1 42970000.0 11662000.0 19932000.0 11376000.0 True False 15288994.934968634 16958223.29432748 10198920.64629742 1.0 1.1091784232030206 0.6670759385870869 23.86599023441611 -6.841362603213685 1.275954422125295 1.058077244357772 0.6521300489399341 0.9267783619815954 0.050881206207973054 0.16722107510852446 0.5282350426371698 0.03126025277088395 0.07204995566747226 1.4409117962280027e-07 6.841362603213685 -0.40594719541783786 KENPLQFK(ub)FR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KENPLQFKFR 10 2 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 A0A2R8Y5S7;P15311 RDX;EZR Radixin;Ezrin 1 47899000.0 15652000.0 14133000.0 18114000.0 True False 15155135.827471638 19776380.602621347 13369399.991648205 1.0 1.304929287850578 0.8821695921334839 23.853303446504786 -6.713175631334121 1.7835263720964156 1.1868589599578805 0.8830550686103817 0.48016534293771584 0.12843521063573304 0.36881577587599557 2.2887592913990096 0.05725972130111393 0.14492870334741867 1.9356390214321063e-07 6.713175631334121 -0.30380389134749874 KENPLQFK(ub)FR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KENPLQFKFR 10 2 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 A0A2R8Y5S7;P15311 RDX;EZR Radixin;Ezrin 1 79857000.0 30371000.0 16362000.0 33124000.0 True False 46075027.41751303 13442073.263110492 26577026.881235022 1.0 0.2917431419259707 0.5768206416982651 25.45748168856125 -10.415674219096667 6.003864231057023 1.0001755445800466 0.43428189181275106 0.840016620934426 0.11638240193175221 0.00027355176948862746 2.6623202625238002e-05 0.11272107315685193 0.03756225870610772 3.839951869589892e-11 10.415674219096667 -0.5658936527672955 KENPLQFK(ub)FR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KENPLQFKFR 10 2 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 A0A2R8Y5S7;P15311 RDX;EZR Radixin;Ezrin 1 44934200.0 11662000.0 9873200.0 23399000.0 True False 15973756.553699952 9436969.377693688 17872638.11753193 1.0 0.5907795918867834 1.1188750784731438 23.929200295939 -6.69985619033515 1.831723188702919 0.7458525245175524 1.1172832137112905 0.41678665325671116 0.17274149152551566 0.39579651955909356 2.581767239803568 0.07524384092971084 0.19351718354692893 1.9959231235434061e-07 6.69985619033515 0.3714306891937381 KENPLQFK(ub)FR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KENPLQFKFR 10 2 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 A0A2R8Y5S7;P15311 RDX;EZR Radixin;Ezrin 1 46375000.0 15652000.0 18182000.0 12541000.0 True False 13015331.501168558 18084049.957155548 15163265.11696754 1.0 1.3894421325751023 1.1650310340236922 23.633708721939062 -10.0983795549962 4.165391269734284 0.9999530839450509 1.2772365832873767 0.6705039582503481 0.09161544755603605 11661730.480007226 7079357.551381407 4728.23916297995 0.031362404462496905 7.972975783516708e-11 10.0983795549962 0.27728349934232577 KENPLQFK(ub)FR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KENPLQFKFR 10 2 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 A0A2R8Y5S7;P15311 RDX;EZR Radixin;Ezrin 1 62316000.0 30371000.0 17686000.0 14259000.0 True False 39315858.201912165 16701758.552756526 11664008.309695141 1.0 0.42480971589078065 0.2966743915341482 25.228608010653698 -13.999999999999831 0.21100497404860366 4.34034741687618 0.2219339436856309 0.9994905996019066 0.006903130448641767 12.770418652199842 0.14558862360537939 17.69349292492676 0.07537024856386158 1.0000000000003886e-14 13.999999999999831 -4.118413473190549 KENQWCEEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 KENQWCEEK 9 1 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 8771200.0 3942900.0 3077600.0 1750700.0 True False 3817734.79773434 4306501.729471982 1292139.150125788 1.0 1.128025375682906 0.3384570219211184 21.86428545748189 -6.865325231340694 1.1584563791441265 1.0707227644467647 0.29612952093245853 0.9597952486275562 0.06937700578374285 0.1414205205521017 0.35765116290730015 0.046595401205957045 0.10951222617922712 1.3635616198850977e-07 6.865325231340694 -0.7745932435143061 down KENQWCEEK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 KENQWCEEK 9 1 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 23881300.0 6540100.0 9807600.0 7533600.0 True False 9921809.845355017 8057357.152871439 6044580.657905824 1.0 0.8120854237741275 0.6092215787360254 23.24217187710988 -6.970148266275487 0.25461943312152574 1.0608291843941613 0.3545009789142248 0.9999835150797887 0.0006478687498471053 0.07625461676605598 0.00885781934042933 0.004386637972609996 0.019299225171995917 1.0711535555737127e-07 6.970148266275487 -0.7063282054799365 KENQWCEEK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KENQWCEEK 9 1 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 9580400.0 3942900.0 3497600.0 2139900.0 True False 3278696.050086729 3478757.7345807557 2587343.1962203 1.0 1.061018673715953 0.7891378635576356 21.644690732916168 -6.847775462998847 1.245802897719552 1.0325096377051404 0.7787281667786149 0.9370023246247552 0.029235346558678706 0.15992083326147535 0.47874836083535516 0.018373210710157024 0.04246005526981273 1.419791386189868e-07 6.847775462998847 -0.2537814709265255 KENQWCEEK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KENQWCEEK 9 1 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 21272300.0 6540100.0 8431900.0 6300300.0 True False 8466288.374644428 7962657.352764196 5153710.046537087 1.0 0.9405133631653098 0.6087331093011034 23.013298199202328 -6.9374002097531395 0.6833239159450161 1.0039444753735889 0.5257150858988998 0.9978031237607886 0.008068601982543312 0.08897306952181815 0.06016293064816062 0.007707285510882145 0.028897956720926255 1.1550473558243516e-07 6.9374002097531395 -0.47822938947468907 KEPAVLELEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEPAVLELEGK 11 1 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 7377490.0 2689430.0 962960.0 3725100.0 False True 2604055.5167695526 1347474.9497700606 2749384.5593954264 1.0 0.5174524663904492 1.0558087343722076 21.31232877547532 -6.670449177730765 1.935880644626221 0.6921065835925571 1.0536312496404807 0.2809733038655996 0.20495529928806883 0.4601004557929142 3.3247279926953 0.08522164498683416 0.2275492987796898 2.1357520026755176e-07 6.670449177730765 0.36152466604792366 KEPSLLSPLHCWAVLLQHTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEPSLLSPLHCWAVLLQHTR 20 1 E7EQN5;P98171;P98171-2;A0A0B4J1X7;E9PCM6;S4R314;S4R352;C9JLA8;C9J5M2;F8WAR0 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 0 7648300.0 4007000.0 1594500.0 2046800.0 False True 3879799.9783209045 2231192.165207651 1510681.677316196 1.0 0.5750791735849392 0.3893710206086416 21.887550846034788 -13.999999999997549 0.11253819689793036 3.0419209718698803 0.06081501377492332 0.9997301949436399 0.004198168834274341 11.998317911413592 0.10220361729613028 5.541550783950369 0.2916701358751462 1.0000000000056445e-14 13.999999999997549 -2.981105958094957 KEPSLLSPLHCWAVLLQHTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KEPSLLSPLHCWAVLLQHTR 20 1 E7EQN5;P98171;P98171-2;A0A0B4J1X7;E9PCM6;S4R314;S4R352;C9JLA8;C9J5M2;F8WAR0 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 0 13576900.0 4007000.0 2202800.0 7367100.0 False True 3331998.040198209 2190933.0791784357 8907526.54837823 1.0 0.6575433276809804 2.673328867819007 21.667956121469064 -6.863173616144874 1.1696812813180397 0.8124069627539746 2.776988378915156 0.9573777108872654 0.1818220446209393 0.14356340730423411 0.37145665980761583 0.1210798687955866 0.2837078389536699 1.3703338438448927e-07 6.863173616144874 1.9645814161611814 up KESDLNGAQIK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KESDLNGAQIKLR 13 2 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 22054100.0 5616300.0 6619500.0 9818300.0 True False 5438013.630707188 9262700.870236477 7246592.687313658 1.0 1.7033243201032409 1.3325808244381456 22.374648336892992 -10.055400002593672 4.372666179525568 0.999964381929092 1.5179525716957585 0.7224061718429303 0.151355398531748 22023352.881708246 16881664.941395868 7097.267479531878 0.05181297978780225 8.802377653344326e-11 10.055400002593672 0.5179881897666665 KESDLNGAQIK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KESDLNGAQIKLR 13 2 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 38734800.0 16173000.0 15525000.0 7036800.0 True False 24535623.404676795 12754442.452621367 5645973.395660994 1.0 0.5198336411615371 0.23011330515387682 24.548374592288138 -8.575229287120084 0.24279807089300204 1.2569831308951664 3.6668041158684637e-20 0.9993824647733448 0.0078898101671217 0.19715712198469162 0.06632641477776245 0.14977149726308012 0.11345048613011545 2.6593206924953374e-09 8.575229287120084 -1.2569831308951664 down KESDLNGAQIK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KESDLNGAQIKLR 13 2 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 12510600.0 4788500.0 3803800.0 3918300.0 True False 6558937.854346799 3635735.538515507 2992878.239921592 1.0 0.5543177293722945 0.45630532052352424 22.645030774970365 -13.999999999999998 0.21282936352820994 3.607987776166513 0.4001349974351287 0.9994917881070996 0.005333944930168798 12.814390776632615 0.14620284068359496 13.994210115585677 0.05692786631113447 1.0000000000000041e-14 13.999999999999998 -3.207852778731384 KESDLNGAQIK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KESDLNGAQIKLR 13 2 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 17153000.0 5616300.0 9082600.0 2454100.0 True False 4670202.294276318 9033670.23104505 2967240.963523644 1.0 1.9343209698039183 0.6353559817227232 22.15505361232727 -6.713658337578048 1.7820071092510323 1.5722271243543782 0.6380423888066961 0.48256494172524766 0.3934988530720911 0.3677514482185735 2.2785968029373223 0.17557263173619103 0.44409572526679486 1.9334888076403138e-07 6.713658337578048 -0.9341847355476821 KESDLNGAQIK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KESDLNGAQIKLR 13 2 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 1 34279700.0 16173000.0 15564000.0 2542700.0 True False 20936267.317491226 14697849.718144434 2079954.690305201 1.0 0.702028183689893 0.0993469685289842 24.319500914380587 -7.342827721634196 0.5947593579287279 1.0015096782147999 6.70338199241975e-23 0.996265019398509 0.022895854505571092 0.10400824540076145 0.07352310195493438 0.02191949888471609 0.06291589873490253 4.541217244721105e-08 7.342827721634196 -1.0015096782147999 down KESPLLFK(ub)FR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KESPLLFKFR 10 2 P26038;V9GZ54 P26038 MSN Moesin 1 6321800.0 1386500.0 3141900.0 1793400.0 True False 1152936.1823645683 3124973.9610816822 2168391.648255286 1.0 2.7104483395365753 1.8807560049057612 20.136881228077748 -10.022818365730865 6.054121076884258 0.9999984278531301 2.2956021722212525 0.76477405162265 0.33872047722430104 7.188111416353292e-06 1.159181895009018e-06 0.32796508751745224 0.10932156394238488 9.48815201757713e-11 10.022818365730865 1.2956037443681225 KESYSIYVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KESYSIYVYK 10 1 Q16778 Q16778 HIST2H2BE Histone H2B type 2-E 0 1116750000.0 412750000.0 261020000.0 442980000.0 False True 541119247.0766858 222076833.44799104 397144678.96420825 1.0 0.41040276177150836 0.7339319033830747 29.011371316568304 -10.153365118394076 5.498431957673813 1.0000094647610225 0.572167332577249 0.6998467062315894 0.13208021897841543 1.5324922666599974e-05 2.3596274262235167e-06 0.12788895016879992 0.04262870737219938 7.024814840122958e-11 10.153365118394076 -0.4278421321837734 KESYSIYVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KESYSIYVYK 10 1 Q16778 Q16778 HIST2H2BE Histone H2B type 2-E 0 804026000.0 259670000.0 96286000.0 448070000.0 False True 251426917.98617154 134733501.92485672 330707025.18813115 1.0 0.5358754066749013 1.3153206817987564 27.905563873321366 -6.745379999728687 1.6667265283863038 0.7255890858472994 1.3163623159118898 0.628972862388117 0.19500019267252267 0.3081590810074291 1.6827360742891095 0.09247709016365409 0.22562824498716913 1.7972976243789803e-07 6.745379999728687 0.5907732300645904 KESYSIYVYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KESYSIYVYK 10 1 Q16778 Q16778 HIST2H2BE Histone H2B type 2-E 0 913720000.0 206290000.0 410690000.0 296740000.0 False True 312957011.8191295 337399160.76438385 238089208.93423796 1.0 1.0781006592668403 0.7607728855483811 28.22138925940485 -6.841599954522291 1.2749156906005246 1.0415426543013917 0.7499986657684266 0.927178575464024 0.036430488254598416 0.16693446313522678 0.5263772435393524 0.022400165411480252 0.051630708044562004 1.4401245219800666e-07 6.841599954522291 -0.29154398853296515 KESYSIYVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KESYSIYVYK 10 1 Q16778 Q16778 HIST2H2BE Histone H2B type 2-E 0 1071290000.0 412750000.0 370270000.0 288270000.0 False True 565354829.149345 353910247.08084977 220186563.1070101 1.0 0.6259966817889518 0.38946614012002234 29.074581378091196 -8.605680926405077 0.15919696400843225 1.4153263482550476 1.1817507120514741e-12 0.9998619752994024 0.002952914547695925 0.20532718733065222 0.04206834354197974 0.18488194969502572 0.14751093870491022 2.4792428737998092e-09 8.605680926405077 -1.4153263482538658 down KESYSIYVYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KESYSIYVYK 10 1 Q16778 Q16778 HIST2H2BE Histone H2B type 2-E 0 606340000.0 259670000.0 204490000.0 142180000.0 False True 215927110.33148715 203388371.78191307 171909180.63395604 1.0 0.9419306888777197 0.7961444969556828 27.685969148755643 -6.955371271794753 0.4963880006074088 1.0030133088834654 0.7288124861972544 0.9995581550653774 0.0018025353080853889 0.08139793591764068 0.027571049291694794 0.0021285494393638326 0.012024837652463477 1.1082270036539595e-07 6.955371271794753 -0.27420082268621104 KESYSIYVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KESYSIYVYK 10 1 Q16778 Q16778 HIST2H2BE Histone H2B type 2-E 0 1164830000.0 206290000.0 599140000.0 359400000.0 False True 267046471.58382922 565797332.3136121 293992887.75541306 1.0 2.118722366777279 1.1009053443461245 27.9925155814973 -6.623643768145676 2.103743864546326 1.740408125758932 1.1048918239546426 0.09509103245435668 0.4806459779358288 0.5756698237771459 4.846449703329217 0.18742130960749206 0.5326524715068045 2.378790699559296e-07 6.623643768145676 -0.6355163018042893 KESYSVYVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KESYSVYVYK 10 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 3283860000.0 968620000.0 958040000.0 1357200000.0 False True 1269870200.1294217 815104166.4106715 1216769963.1816862 1.0 0.6418799073539944 0.9581845160691828 30.242033893346107 -10.236852422599155 7.6870687934185895 1.0000002720143952 0.8000322130666072 0.34764280169791095 0.12913081577381677 6.019636140719349e-07 5.974381951970517e-08 0.12503054521426116 0.0416767915811809 5.796256252732246e-11 10.236852422599155 -0.19996805894778802 KESYSVYVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KESYSVYVYK 10 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 2033830000.0 486610000.0 210320000.0 1336900000.0 False True 471162831.9068467 294301872.8043107 986725783.8596933 1.0 0.6246287968285599 2.0942351922504323 28.811650494492582 -6.838956394823791 1.2871755729691121 0.8002679936537953 2.1415966527324763 0.92264692097398 0.1733912883810618 0.17002780671304976 0.5476579523524386 0.10564302142883691 0.2433250069800071 1.4489173242476548e-07 6.838956394823791 1.341328659078681 up KESYSVYVYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KESYSVYVYK 10 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 2622952000.0 634177600.0 1314374400.0 674400000.0 False True 962093783.7928511 1079814019.0659409 541104544.3999797 1.0 1.1223583784202438 0.5624239066037716 29.841602292198306 -6.849466427068124 1.237777554054344 1.065264321965597 0.540284354062013 0.9395035471573041 0.05911984268438455 0.15805223920470385 0.4662666821799335 0.03738059801191132 0.08646600280450503 1.414274050638683e-07 6.849466427068124 -0.524979967903584 KESYSVYVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KESYSVYVYK 10 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 2093405800.0 968620000.0 467500000.0 657285800.0 False True 1326744989.971261 446844304.18423676 502048431.2659713 1.0 0.33679743097723397 0.3784061255636219 30.305243954869 -10.00481995259404 6.420416549091684 1.0000002620196635 0.35760177827041817 0.9968634190957255 0.01698667843336111 6.369108316062125e-08 9.924867311694243e-09 0.016447287286936584 0.005482426889977164 9.8896300849922e-11 10.00481995259404 -0.6423984837492454 KESYSVYVYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KESYSVYVYK 10 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 1359808290.0 486610000.0 589458290.0 283740000.0 False True 404637775.47812575 586282761.193461 343068722.1344681 1.0 1.4489076322661691 0.8478415583643747 28.59205576992686 -6.706780337588248 1.8066103123169102 1.2768838421503939 0.8493809156055678 0.44979328475599867 0.18926583250301993 0.38160478346191123 2.4258070079601155 0.08343212269418032 0.21279413377329665 1.9643535787495486e-07 6.706780337588248 -0.427502926544826 KESYSVYVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KESYSVYVYK 10 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 2748318000.0 634177600.0 1374918800.0 739221600.0 False True 820955404.7093949 1298403360.1292388 604690853.8541381 1.0 1.5815759938736902 0.7365696728291703 29.612728614290756 -6.721501122181335 1.7539049248011973 1.3532530409401886 0.7377730776885016 0.5196087433425295 0.2446849558665384 0.3524029208561835 2.119393409032728 0.11073727699015033 0.277503321489615 1.8988859355294485e-07 6.721501122181335 -0.615479963251687 KESYSVYVYK(ub)VLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KESYSVYVYKVLK 13 2 P57053;O60814;P58876;Q99880;Q99879;P62807;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 10596200.0 4855400.0 2502100.0 3238700.0 True False 6650572.592251313 2391548.9486617693 2473785.7631202447 1.0 0.3596004577783574 0.3719658313334541 22.6650471265454 -9.975217355093967 5.370271577531562 1.000001825814702 0.36578314455457456 0.9997149789381825 0.0050481426220995145 3119393.162281731 5794236.205463808 49.546500382137154 0.0017281134982535782 1.0587237239948435e-10 9.975217355093967 -0.6342186812601276 KETEGDVTSVK(ub)DAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KETEGDVTSVKDAK 14 2 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 26983400.0 9969900.0 12644000.0 4369500.0 True False 13070635.448648931 10757564.485925986 3917386.0552036366 1.0 0.823033013826268 0.2997089216200704 23.639825945844454 -6.951773520126091 0.5390234517352386 1.0077545601583333 0.09086071954273404 0.9993332033650073 0.007677517284256765 0.08278133578606302 0.0330750485520538 0.00845576708013371 0.0433319431432503 1.1174458317739452e-07 6.951773520126091 -0.9168938406155993 down KETEGDVTSVK(ub)DAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KETEGDVTSVKDAK 14 2 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 29355100.0 10552000.0 13490000.0 5313100.0 True False 10217032.535872784 18876627.349420656 3921439.720416591 1.0 1.8475645725060943 0.3838139603302736 23.284472900855537 -6.74972193684907 1.6510119229928741 1.4985421240087862 0.38098963832462257 0.647734248119944 0.3561457740783089 0.3005221745461669 1.611667276433164 0.17041621924690856 0.4138229539098621 1.7794183430149293e-07 6.74972193684907 -1.1175524856841637 KETEGDVTSVK(ub)DAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KETEGDVTSVKDAK 14 2 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 23085400.0 9969900.0 10184000.0 2931500.0 True False 13656041.456416843 9734037.20601553 2239140.0761376503 1.0 0.7128007949508383 0.16396699462899622 23.703036007367345 -7.248831116029069 0.5180822795178361 1.0087880141746004 5.371504102766223e-23 0.9986524199703279 0.012732117787829763 0.09375671232205021 0.04555423397919239 0.01367371777417434 0.05297600279123776 5.6385688006199546e-08 7.248831116029069 -1.0087880141746004 down KETEGDVTSVK(ub)DAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KETEGDVTSVKDAK 14 2 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 29323000.0 10552000.0 18771000.0 0.0 True False 8774455.532860383 18669876.897248212 0.0 1.0 2.1277533206851893 0.0 23.064878176289813 -6.767075453625503 1.6141168188645112 1.6526698933536432 6.811347909356568e-10 0.7017202861354055 0.47469897126804383 0.2752049421535771 1.419228513443499 0.23298004734174915 0.5497870585048039 1.709718245583871e-07 6.767075453625503 -1.6526698926725085 KETK(ub)PEPMEEDLPENKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KETKPEPMEEDLPENKK 17 3 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 7373900.0 2790300.0 2660900.0 1922700.0 True False 2701723.453832999 3723411.2464101897 1419087.1902363915 1.0 1.378161499515318 0.5252525709924526 21.365448578479917 -6.786190174901316 1.5116592275149634 1.212405957664979 0.5171260275196701 0.788703659022828 0.16039812048143093 0.2410770328182162 1.0883489280178744 0.08354082441281477 0.19613449243235673 1.6360999263771379e-07 6.786190174901316 -0.695279930145309 KETK(ub)PEPMEEDLPENKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KETKPEPMEEDLPENKK 17 3 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 7973700.0 2314100.0 3166300.0 2493300.0 True False 3169685.3062010915 3026402.3964460925 1904433.8911253626 1.0 0.9547958563978941 0.6008274346350967 21.595908182647914 -6.930497067948535 0.7427030326591104 1.0052848252979802 0.5272316823724323 0.9966349700564731 0.010353058247867338 0.09238071711157429 0.07642250200410156 0.009460141764542355 0.03194099278477428 1.173553605474649e-07 6.930497067948535 -0.4780531429255479 KETK(ub)PEPMEEDLPENKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KETKPEPMEEDLPENKK 17 3 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 7722500.0 2790300.0 3648600.0 1283600.0 True False 2320258.081249081 3628944.267609607 1551994.8253041639 1.0 1.5640261300829137 0.6688888782874823 21.145853853914193 -6.736371631413553 1.6997860886551144 1.33698862492826 0.6687469251484853 0.5886528767063279 0.2370087347734214 0.32440870095426466 1.8389083854479344 0.11036743492624461 0.2719383011360689 1.8349674659053255e-07 6.736371631413553 -0.6682416997797748 KETKPEPMEEDLPENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KETKPEPMEEDLPENK 16 2 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 0 4369870.0 1120900.0 616070.0 2632900.0 False True 1085317.6430496408 862069.9637626087 1943264.504693084 1.0 0.7943019900978233 1.7905030081632995 20.04968591151974 -6.852864962469234 1.2211771079950506 0.8899014801251767 1.8325853406816803 0.9443722578062713 0.10128128498734068 0.15433396343157532 0.44145414783965453 0.06484719905970009 0.15036205084775223 1.4032499568294196e-07 6.852864962469234 0.9426838605565037 KETKPEPMEEDLPENKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KETKPEPMEEDLPENKK 17 3 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 0 8345500.0 2075300.0 1110000.0 5160200.0 False True 2009420.7374617856 1553228.788573529 3808588.817318261 1.0 0.7729734045322442 1.8953665334065914 20.938348240064396 -6.854068512988317 1.2153863621629526 0.8782947648422539 1.9438596248614666 0.946006073827645 0.11258998985703526 0.15304057595520715 0.4330007633337795 0.07240744079980369 0.16804110675491407 1.3993665453105938e-07 6.854068512988317 1.0655648600192127 KEVVEEAENGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KEVVEEAENGR 11 1 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 22200520.0 158220.0 12089100.0 9953200.0 False True 207427.95220465976 10285453.402942726 8923338.34183611 1.0 49.58566718527181 43.01897717734713 17.662250793803953 -9.245338325722168 9.817413843927248 0.999999995348325 46.3023221813125 0.9844860308628449 2.6808399697523715 0.0 0.0 2.59571213916958 0.8652373797231933 5.684099534596003e-10 9.245338325722168 45.30232218596417 KEVVEEAENGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KEVVEEAENGR 11 1 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 19731810.0 6021000.0 1809410.0 11901400.0 False True 5829866.650728777 2531916.848948498 8784066.30565319 1.0 0.4343009884509089 1.506735373536394 22.475031453687766 -6.763367124033242 1.5995859831298649 0.6727874100832334 1.5113485981531491 0.7046300468994526 0.23806577154352554 0.27730075785749847 1.3990720430199342 0.11738158630972245 0.28118033542797316 1.7243795984382469e-07 6.763367124033242 0.8385611880699158 KEVVEEAENGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KEVVEEAENGR 11 1 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 20421420.0 158220.0 9695100.0 10568100.0 False True 216718.20973472917 9266738.424591623 8072132.436851526 1.0 42.75938988207056 37.24713510107021 17.725460855326844 -9.922771702617826 11.082451758346464 1.0000000017550452 40.00326262511474 0.9852408827780377 2.250368590944652 0.0 0.0 2.1789100188892254 0.7263033396297417 1.194615918143213e-10 9.922771702617826 39.003262623359696 KFDEALK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFDEALKLR 9 2 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0;H0YHB8 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 1 4958550.0 710150.0 1311700.0 2936700.0 True False 687606.6769664572 1835468.650425135 2167490.170888443 1.0 2.6693583874472364 3.1522238563052487 19.391224028530893 -9.869451662865472 0.3170767922001803 1.8950837080560575e-23 3.2997483754458883 0.9987896846337904 0.032078572867584206 1.2461779205177383 0.13855169942612244 1.3446783923768129 0.1600185223374667 1.350667149236717e-10 9.869451662865472 3.2997483754458883 KFDEALK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFDEALKLR 9 2 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0;H0YHB8 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 1 31036200.0 2374200.0 3614000.0 25048000.0 True False 3601834.977269753 2969053.4636891223 20097251.821071602 1.0 0.8243169058066373 5.579725875255294 21.78030065314238 -6.898322007926211 0.9718278133416387 0.7930819418182393 6.062197526167735 0.9857124549902948 0.263144169097872 0.11265053787905746 0.18447330382634408 0.20370725947936213 0.5256801225146063 1.2637989554412397e-07 6.898322007926211 5.269115584349496 up KFDEALK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFDEALKLR 9 2 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0;H0YHB8 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 1 5124750.0 710150.0 2214200.0 2200400.0 True False 590521.1899792266 2202271.6651157136 2660493.466499908 1.0 3.729369415504269 4.505331073036514 19.17162930396517 -9.510404758493562 0.37289904603125384 5.092182686785843e-15 4.651842811255009 0.9983719497791607 0.06065639347482803 0.859762084081221 0.15289371560144482 1.3352499311621608 0.21147612029907176 3.087416647083198e-10 9.510404758493562 4.651842811255004 KFDEALK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFDEALKLR 9 2 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0;H0YHB8 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 1 17498400.0 2374200.0 4193200.0 10931000.0 True False 3073448.702478682 3959844.7338809613 8941670.161531502 1.0 1.2884043682549238 2.9093279332497737 21.55142697523483 -6.9372336332311555 0.6848128477626498 0.9806436561944226 3.3130247935453885 0.9977786913977968 0.039607612831860387 0.08905158632047014 0.060527914073121095 0.03779031104543349 0.1412937487905006 1.1554904668535422e-07 6.9372336332311555 2.332381137350966 up KFDLGQDVIDFTGHALALYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFDLGQDVIDFTGHALALYR 20 1 P31150;P50395;P50395-2;Q5SX91;Q5SX87 P31150;P50395 GDI1;GDI2 Rab GDP dissociation inhibitor alpha;Rab GDP dissociation inhibitor beta 0 163050000.0 41448000.0 52470000.0 69132000.0 False True 62879646.25468645 43106318.550018884 55468029.89836806 1.0 0.6855369124600657 0.8821301200344142 25.906089765585964 -10.39159299648686 5.8239432402391795 1.0000618668125099 0.7838335173398264 0.6171588960279525 0.08025884090903619 6.44906014467418e-05 6.73702272704126e-06 0.07773247579658686 0.02590342951888381 4.058887400460348e-11 10.39159299648686 -0.21622834947268343 KFDQLLAEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFDQLLAEEK 10 1 P35579;P35579-2;P35749-2;P35749;P35749-3;P35749-4;A0A0C4DFM8;A1L2Z2;Q7Z406;Q7Z406-6;Q7Z406-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;Q7Z406;P35580 MYH9;MYH11;MYH14;MYH10 Myosin-9;Myosin-11;Myosin-14;Myosin-10 0 7916400.0 3076700.0 0.0 4839700.0 False True 2979031.84260043 0.0 3572037.382112164 1.0 0.0 1.19905981904312 21.506412113830116 -10.75683111100059 6.220501370633823 1.0123009223946304 0.59952990952156 0.12947306310778017 0.4895141212882627 0.08348222511864384 0.003263444502910795 0.47382153182944564 0.15799000329023327 1.7505273035970897e-11 10.75683111100059 -0.4127710128730704 KFEQLK(ub)QER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFEQLKQER 9 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 85175000.0 29216000.0 32108000.0 23851000.0 True False 38302458.92814646 27317611.55600377 21383127.31494724 1.0 0.7132077762226774 0.5582703542626583 25.19093367697718 -13.999999999999998 0.07552827043413211 2.592007667320876 0.05472885324486187 0.9999044647162322 0.001788611137303741 12.30350518022602 0.07600063299136142 3.344888354597992 0.46000394776924924 1.0000000000000041e-14 13.999999999999998 -2.5372788140760143 KFEQLK(ub)QER ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFEQLKQER 9 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 115246000.0 42435000.0 44693000.0 28118000.0 True False 41087924.152744584 62539147.97091603 20753052.278081257 1.0 1.5220809826854822 0.5050888480258012 25.29221110860876 -6.767143681616206 1.5853045375826633 1.3005302739136597 0.49996055239853837 0.7196043857604433 0.2198767114840092 0.27104255643710784 1.3438723264332109 0.10935238965196119 0.2610008772044402 1.709449668655189e-07 6.767143681616206 -0.8005697215151213 KFEQLK(ub)QER ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFEQLKQER 9 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 169566000.0 55839000.0 72776000.0 40951000.0 True False 84711845.37771282 59788554.19851677 32857016.90053905 1.0 0.705787412987308 0.3878680337329015 26.336060381972313 -6.996931943734052 0.258077851161358 1.0926915210677213 4.5879973037949345e-12 0.9999835298339206 0.0010144249621445848 0.07356193298869437 0.00889870032876456 0.006720652122874692 0.02921864091791042 1.0070894727888466e-07 6.996931943734052 -1.0926915210631332 down KFEQLK(ub)QER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFEQLKQER 9 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 84746000.0 29216000.0 29263000.0 26267000.0 True False 40017944.73271293 27970063.90019956 20063275.585846025 1.0 0.6989380410967294 0.5013569717248665 25.254143738500073 -8.442783403297256 0.12026992377237478 1.4923202761517622 3.183318287199754e-11 0.9999602924839135 0.001291936752061997 0.1278507315091714 0.028274343054877287 0.17047727463992363 0.15624246454449345 3.6075852010317553e-09 8.442783403297256 -1.492320276119929 KFEQLK(ub)QER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFEQLKQER 9 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 113324000.0 42435000.0 53113000.0 17776000.0 True False 35286582.689246565 52826869.72689491 21492879.413062368 1.0 1.4970809214402525 0.609094952671975 25.072616384043037 -6.754833070234425 1.632295907934069 1.290586247155751 0.606694554114594 0.6693735487588661 0.20894484284588744 0.29168564371489897 1.530491067765658 0.10106751968479998 0.24410012241638346 1.7585994369149522e-07 6.754833070234425 -0.6838916930411569 KFEQMK(ub)QDR ddPTM_RPMI8226_Bortezomib_1h_R1 2 KFEQMKQDR 9 2 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;H0YAW6 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 146284000.0 49786700.0 63592900.0 32904400.0 True False 65270845.83508866 54105087.20318267 29499768.32929225 1.0 0.8289319145623291 0.4519593388421144 25.95993539930299 -6.958105282090533 0.4613649557897694 1.0108395797137524 0.2548204395477 0.9996933320585738 0.004009176459875796 0.08038507394828344 0.02368594745767735 0.005131694198271994 0.031137173388273806 1.101272305676033e-07 6.958105282090533 -0.7560191401660523 down KFEQMK(ub)QDR ddPTM_RPMI8226_Bortezomib_2h_R1 2 KFEQMKQDR 9 2 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;H0YAW6 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 160090800.0 64981800.0 63607300.0 31501700.0 True False 62918988.32823902 89006026.5976874 23250459.739257175 1.0 1.41461312336041 0.36953009507977114 25.90699213811888 -6.799077383812088 1.4597561303424036 1.229035713815803 0.3554467982660996 0.8294030777961535 0.1774708026285858 0.22209488082447948 0.9344363415759851 0.09564824916658389 0.2225608876616958 1.5882637220868546e-07 6.799077383812088 -0.8735889155497034 down KFEQMK(ub)QDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFEQMKQDR 9 2 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;H0YAW6 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 12805500.0 6559400.0 4027600.0 2218500.0 True False 9951089.356374009 3308843.312217571 1780012.5025969052 1.0 0.3325106622721808 0.1788761449978084 23.24642303699177 -13.999999999999895 0.20638383520246534 4.8041091797856765 0.08514847688543792 0.9994883025886593 0.008062735860296483 12.664468098135968 0.14401642379962884 19.502433247387852 0.09336714307732057 1.0000000000002414e-14 13.999999999999895 -4.7189607029002385 KFEQMK(ub)QDR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 KFEQMKQDR 9 2 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;H0YAW6 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 147218700.0 49786700.0 60863900.0 36568100.0 True False 68194188.42497809 58174731.6479977 27931467.92365994 1.0 0.8530746239761616 0.40958721804260423 26.02314546082588 -6.951312601829401 0.5442415592435943 1.0063532493587037 0.23567886994433707 0.99930031283832 0.006638449827645057 0.08296288699177491 0.033813719071291035 0.007259740468055175 0.036752856526813156 1.1186324106057613e-07 6.951312601829401 -0.7706743794143667 down KFEQMK(ub)QDR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 KFEQMKQDR 9 2 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;H0YAW6 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 156645900.0 64981800.0 74810000.0 16854100.0 True False 54035245.881844856 74406983.68137771 20378214.385446344 1.0 1.37700832978679 0.3771281883311122 25.687397413553157 -6.804536548812101 1.4371432136656463 1.2068331322704073 0.36170000223047294 0.8451440224788828 0.16224423288528675 0.21434271573093938 0.8734344901848148 0.08879070929888816 0.20596730784258058 1.5684238986682716e-07 6.804536548812101 -0.8451331300399344 down KFEQMK(ub)QDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFEQMKQDR 9 2 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2;H0YAW6 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 12112780.0 6559400.0 4678600.0 874780.0 True False 8491272.6051043 4418231.797180067 715579.0160007812 1.0 0.5203262223054959 0.08427229336279113 23.01754935908422 -7.920127059026956 0.4586147035646339 1.0359573217100926 1.1621653851106604e-19 0.9959487163790548 0.023804069785520587 0.10455192519945848 0.10110745553696313 0.0390819097083643 0.07907116209284852 1.2019127465073716e-08 7.920127059026956 -1.0359573217100926 down KFFLSHPAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFFLSHPAYR 10 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3;K7EMQ3;Q9UQ16-3;E5RIK2;E5RHK8;Q9UQ16-2;Q9UQ16-5;Q9UQ16;Q9UQ16-4 P50570 DNM2;DNM3 Dynamin-2;Dynamin-3 0 6373970.0 2267700.0 3168400.0 937870.0 False True 2972976.6604380375 2695687.070326469 840828.2090842974 1.0 0.9067299808298149 0.2828236831702574 21.5034767066355 -6.933579475600326 0.7167991797627741 1.0083439533509706 0.1422233150874956 0.9971962087914168 0.016858558910859207 0.0908213063671326 0.06888353405361333 0.01570015273047868 0.055383669017268884 1.1652537906585946e-07 6.933579475600326 -0.866120638263475 down KFFLSHPAYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFFLSHPAYR 10 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3;K7EMQ3;Q9UQ16-3;E5RIK2;E5RHK8;Q9UQ16-2;Q9UQ16-5;Q9UQ16;Q9UQ16-4 P50570 DNM2;DNM3 Dynamin-2;Dynamin-3 0 3895480.0 1660000.0 844380.0 1391100.0 False True 1607304.2086380601 1181545.3373835303 1026729.1778945477 1.0 0.7351099630260447 0.6387895784610311 20.61621157783828 -13.999999999999998 0.14071666087346213 2.2661583592984003 0.5206110037479988 0.9996000909102106 0.0030540963968661962 11.934769644378338 0.11758084789365954 4.147705732280516 0.10570157355820022 1.0000000000000041e-14 13.999999999999998 -1.7455473555504013 KFFLSHPAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFFLSHPAYR 10 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3;K7EMQ3;Q9UQ16-3;E5RIK2;E5RHK8;Q9UQ16-2;Q9UQ16-5;Q9UQ16;Q9UQ16-4 P50570 DNM2;DNM3 Dynamin-2;Dynamin-3 0 5328100.0 2267700.0 1597600.0 1462800.0 False True 3106129.9722882356 1527012.749443285 1117316.7673116678 1.0 0.4916126379342586 0.3597134625015574 21.56668676815839 -13.999999999999998 0.1894214783655336 3.719837503974268 0.26453492950407187 0.999489735905208 0.006235650353044141 12.341342771263161 0.13801810790173438 12.386793838004056 0.09112774445167901 1.0000000000000041e-14 13.999999999999998 -3.4553025744701964 KFFLSHPAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFFLSHPAYR 10 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3;K7EMQ3;Q9UQ16-3;E5RIK2;E5RHK8;Q9UQ16-2;Q9UQ16-5;Q9UQ16;Q9UQ16-4 P50570 DNM2;DNM3 Dynamin-2;Dynamin-3 0 3233000.0 1660000.0 0.0 1573000.0 False True 1380363.5504689373 0.0 1901907.0272697476 1.0 0.0 1.37783051908581 20.396616853272555 -6.71202095898837 1.7877593150271631 0.3865091879460843 1.3748279223660953 0.4748214797498148 0.42126247453264126 0.3710191398609775 2.3127040827500296 0.1874208765010274 0.4750169400560582 1.9407922129834725e-07 6.71202095898837 0.9883187344200111 KFFQMVGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFFQMVGLK 9 1 B8ZZ19;P20472;H0Y3U0 B8ZZ19 PVALB Parvalbumin alpha 0 13839300.0 4037300.0 3839700.0 5962300.0 False True 5292939.397268816 3266831.727033372 5345378.390420102 1.0 0.617205579326881 1.0099073481132892 22.335637704921698 -10.908457560922434 11.324548555215916 1.0171344612450919 0.8135564637222198 0.23109083506302774 0.16031982576918635 0.06315165719754466 0.0005104880362575789 0.1413438345106957 0.05174300127257779 1.2346459583695842e-11 10.908457560922434 -0.2035779975228721 KFFQMVGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFFQMVGLK 9 1 B8ZZ19;P20472;H0Y3U0 B8ZZ19 PVALB Parvalbumin alpha 0 14053000.0 5755700.0 2101000.0 6196300.0 False True 5572988.454010899 2939940.256570263 4573303.144984528 1.0 0.5275338861422506 0.8206195262602969 22.410019733800937 -10.395887678678054 6.130335534007943 1.0000645214577195 0.6740767062012746 0.6224773042323166 0.11965171153769964 0.00010553456367512021 1.0399839511879467e-05 0.11587511040737837 0.038617423844227 4.01894739204778e-11 10.395887678678054 -0.32598781525644493 KFFQMVGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFFQMVGLK 9 1 B8ZZ19;P20472;H0Y3U0 B8ZZ19 PVALB Parvalbumin alpha 0 12202800.0 4037300.0 3996200.0 4169300.0 False True 5529998.913930105 3819634.6703337845 3184597.2094288594 1.0 0.6907116492757528 0.5758766428338417 22.39884776644459 -13.999999999999998 0.1376127912352977 2.4746012927481473 0.42959048487818374 0.9996126199805174 0.0035252543654701956 11.932364170603211 0.11604570932121298 4.7316490414176435 0.13057986963225396 1.0000000000000041e-14 13.999999999999998 -2.0450108078699634 KFFQMVGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFFQMVGLK 9 1 B8ZZ19;P20472;H0Y3U0 B8ZZ19 PVALB Parvalbumin alpha 0 10242300.0 5755700.0 2858000.0 1628600.0 False True 4786119.570743416 2842603.386731416 1969132.7302043976 1.0 0.5939265295643003 0.4114257283167994 22.190425009235213 -13.999999999999996 0.10803935679905304 2.9664859247688753 0.06698313948399136 0.9997530283963344 0.0038658884124188257 12.024529563507835 0.09941573941738374 5.177451177684098 0.3061050851207558 1.0000000000000082e-14 13.999999999999996 -2.899502785284884 KFFVGGNWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFFVGGNWK 9 1 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 114543100.0 58323100.0 56220000.0 0.0 False True 76462148.90170382 47832195.14384362 0.0 1.0 0.625566974390616 0.0 26.18824241063399 -7.5901302380910005 0.6815061646802517 0.9960942285013772 6.6497049443137895e-21 0.98710798234371 0.04683845138170112 0.12110785211143257 0.14614190444675165 0.0422633471269676 0.0769992849234692 2.5696250770296008e-08 7.5901302380910005 -0.9960942285013772 down KFFVGGNWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFFVGGNWK 9 1 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 53047000.0 37018000.0 16029000.0 0.0 False True 35842883.852628715 22429463.290130723 0.0 1.0 0.6257717259122203 0.0 25.09518338287122 -7.589650093165406 0.6816716430326034 0.9960771909811126 6.773782036196744e-21 0.9871071157125908 0.046841599522459365 0.12110409203611641 0.14612080523251292 0.042260840758482444 0.07699340858356996 2.5724675601120005e-08 7.589650093165406 -0.9960771909811126 down KFFVGGNWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFFVGGNWK 9 1 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 178373500.0 67603500.0 0.0 110770000.0 False True 102559451.97786848 0.0 88876260.94778436 1.0 0.0 0.8665828378935094 26.611885217208325 -9.051342190194898 11.530144986569574 0.9999067774182178 0.4332914189467056 0.36314426112575393 0.3537809662096048 0.0 0.0 0.34254694573376027 0.11418231524458672 8.885007726425959e-10 9.051342190194898 -0.5666153584715121 KFFVGGNWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFFVGGNWK 9 1 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 80513100.0 37018000.0 26730100.0 16765000.0 False True 30782107.175457276 26586099.645790555 20270483.987398166 1.0 0.8636868000702623 0.6585151520608025 24.875588658305496 -6.965200227489772 0.3545994395871009 1.0188070011619204 0.4964225302200922 0.999917211624468 0.001277024962983141 0.07789307790822216 0.014620751328413424 0.00278507448159913 0.017582586861344417 1.0834272946350007e-07 6.965200227489772 -0.5223844709418282 KFFVGGNWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFFVGGNWK 9 1 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 302312500.0 67603500.0 226630000.0 8079000.0 False True 87514063.41420995 214017841.2762188 6608704.897540304 1.0 2.4455251296383986 0.075515918695957 26.383011539300774 -6.741651895624057 1.680546007886121 1.8584822853736103 0.07362862855779971 0.6122322807306277 0.607338498897118 0.31491290080319906 1.746920537334385 0.2858153973363468 0.7001253048401394 1.8127925360791378e-07 6.741651895624057 -1.7848536568158107 KFGDPVVQSDMK(ub)HWPFQVINDGDKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFGDPVVQSDMKHWPFQVINDGDKPK 26 3 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 26535000.0 8706200.0 8876900.0 8951900.0 True False 8429826.446532942 12421492.462421972 6607128.8387565175 1.0 1.473516986524763 0.7837799367119744 23.007071498557522 -6.721939823130545 1.7522215930658964 1.2874846931123065 0.784729359462534 0.521673543664698 0.1992122111792142 0.35157967661199685 2.1105945032345583 0.09023382593452632 0.22601518392085418 1.8969687514734229e-07 6.721939823130545 -0.5027553336497725 KFGDPVVQSDMK(ub)HWPFQVINDGDKPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFGDPVVQSDMKHWPFQVINDGDKPK 26 3 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 157101100.0 23409100.0 34004000.0 99688000.0 True False 35513316.13444751 27935720.525535386 79984623.10519746 1.0 0.7866266394209821 2.25224315302995 25.081856745701064 -6.869921315044674 1.1344356430007525 0.8793667527787362 2.3379767470960204 0.9646085170794686 0.12162381932815286 0.13693432260293184 0.32940767934055726 0.08320423135952007 0.19697382292336796 1.3492073082166528e-07 6.869921315044674 1.458609994317284 up KFGDPVVQSDMK(ub)HWPFQVINDGDKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFGDPVVQSDMKHWPFQVINDGDKPK 26 3 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 144467100.0 23409100.0 30894000.0 90164000.0 True False 30303541.41234674 29174721.741991416 73755077.16076544 1.0 0.9627495791664996 2.433876495065854 24.852983067793513 -6.901090243418258 0.9543380497647534 0.9406521584358071 2.5917676191634236 0.9871012857223763 0.0777840749973444 0.11060760349564586 0.17292335307633955 0.06100148736749481 0.15960353247238576 1.255768996387248e-07 6.901090243418258 1.6511154607276164 up KFGTINIVHPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFGTINIVHPK 11 1 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 12845200.0 2952500.0 4698000.0 5194700.0 False True 3870756.0920506744 3997076.712660565 4657202.275080983 1.0 1.0326346113280849 1.203176372865607 21.88418397127748 -6.938824504990818 0.6704067395381837 0.9980413016604993 1.247618662940377 0.9980058934129871 0.0039782607978742345 0.08830691300866095 0.05708184600450646 0.0038388935862213635 0.014755821373157837 1.1512655123662431e-07 6.938824504990818 0.24957736127987762 KFGTINIVHPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFGTINIVHPK 11 1 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 9626850.0 2726800.0 964150.0 5935900.0 False True 2640239.2265748563 1349140.1229758286 4381109.716817077 1.0 0.5109916212880635 1.659360891513087 21.33223722442189 -6.790994694244081 1.492284886875799 0.7270466231173833 1.671923933628085 0.8045546549135061 0.2080202483685704 0.23387027111500353 1.0288407452178225 0.10971398247171185 0.25669034923809936 1.6180998057739925e-07 6.790994694244081 0.9448773105107016 KFGTINIVHPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFGTINIVHPK 11 1 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 9550900.0 2952500.0 3262300.0 3336100.0 False True 4044119.0383123984 3118160.799016541 2548181.889136215 1.0 0.7710358595966904 0.6300956685487591 21.94739403280037 -10.811705189865297 0.06796419734245249 1.9707839437181718 7.318282435245078e-13 0.9999744149545077 0.000771001639025815 3.015951674928027 0.04022993527397349 0.846350839823211 0.38362878737245293 1.5427473537004743e-11 10.811705189865297 -1.97078394371744 KFGTINIVHPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFGTINIVHPK 11 1 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 6557300.0 2726800.0 2527400.0 1303100.0 False True 2267455.017722107 2513784.3945503784 1575572.1851463495 1.0 1.1086369409328944 0.6948637008592896 21.112642499856165 -6.836919627541039 1.2965057685956212 1.0578370667842762 0.6820538788703017 0.9190449684043409 0.04983659607376454 0.17242867669970285 0.564324440251682 0.030154728415719177 0.0694283304163509 1.455728459206554e-07 6.836919627541039 -0.3757831879139746 KFGTINIVHPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFGTINIVHPK 11 1 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 9861100.0 2506900.0 3496100.0 3858100.0 False True 3245231.4683867437 3301538.9616811117 3155965.3874489716 1.0 1.017350840407806 0.9724931543998162 21.629889952443566 -6.801813962345273 1.4483767110797707 1.0095511977726759 0.9718449414371214 0.8374574805699422 0.0074460089096967125 0.21817054787209209 0.9033508580421735 0.004043912280347948 0.00939495456620539 1.578287211908566e-07 6.801813962345273 -0.03770625633555447 KFGVVVVGVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFGVVVVGVGR 11 1 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 27716300.0 9559200.0 9692900.0 8464200.0 False True 12532203.771424497 8246757.102628283 7588405.778339547 1.0 0.6580452451174036 0.6055124794285879 23.57913679719094 -13.999999999999998 0.2637177319073983 3.5525491524896147 0.5869849821119769 0.9995700087705435 0.003626782165334724 14.58483153292833 0.16252357731632386 19.884181004339265 0.02252571724050682 1.0000000000000041e-14 13.999999999999998 -2.965564170377638 KFGVVVVGVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFGVVVVGVGR 11 1 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 19890000.0 6958200.0 6845500.0 6086300.0 False True 6737315.749726108 9578943.848810893 4492115.444913794 1.0 1.4217745174256238 0.6667515093227465 22.68374248329824 -6.755114610402905 1.6309108425122323 1.246477801348119 0.6646465041884505 0.6706576704207121 0.1772968978105982 0.29121998760371337 1.5254735275040228 0.08582294109110983 0.2072490254318621 1.757459758764621e-07 6.755114610402905 -0.5818312971596685 KFGVVVVGVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFGVVVVGVGR 11 1 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 49890500.0 12974500.0 23640000.0 13276000.0 False True 19683265.063004967 19421257.299836967 10651992.78092248 1.0 0.98668880582925 0.5411700115212634 24.230466219212644 -6.913279847575322 0.8730909612905354 1.0124048676232753 0.4793622798862969 0.9921017537956698 0.018949864533048495 0.102289243200219 0.12729449942212767 0.015770605842700618 0.04459050218340372 1.221012619230451e-07 6.913279847575322 -0.5330425877369784 KFGVVVVGVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFGVVVVGVGR 11 1 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 21067300.0 9559200.0 7323000.0 4185100.0 False True 13093494.567666687 6999445.646077356 3196665.57484007 1.0 0.5345742964114343 0.24414151304831747 23.642346858713832 -8.48106820789806 0.2390307863947336 1.2491898595139543 7.341836524776458e-12 0.9994538532748769 0.00727553279477474 0.15395222069544434 0.06166306794466995 0.1345927303438099 0.1129455182844764 3.3031765909152055e-09 8.48106820789806 -1.2491898595066124 down KFGVVVVGVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFGVVVVGVGR 11 1 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 13684670.0 6958200.0 3247700.0 3478770.0 False True 5786051.600525874 3230203.995482025 4206164.722984865 1.0 0.5582743152840952 0.7269490515090777 22.464147758732516 -10.09662588717638 5.84674454530176 1.0000018678529572 0.6426116833965638 0.8568516683722738 0.0688611727083726 1.6766398885096913e-06 2.590585985756969e-07 0.06667489196463526 0.022224847924974894 8.005235503645506e-11 10.09662588717638 -0.35739018445639337 KFGVVVVGVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFGVVVVGVGR 11 1 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 67906300.0 12974500.0 33560000.0 21371800.0 False True 16795746.01563038 31692356.49838909 17482351.69318627 1.0 1.8869275868363153 1.0408797368641394 24.001592541305094 -10.453829445542091 4.684334021548111 0.9987177214815652 1.463903661850388 0.2861583247602072 0.3453975884023759 0.004637309543099242 0.0005406863387701746 0.33528930487560804 0.11147659230846443 3.516985311052373e-11 10.453829445542091 0.46518594036882277 KFGYVDFESAEDLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFGYVDFESAEDLEK 15 1 P19338 P19338 NCL Nucleolin 0 12221500.0 3239100.0 5141900.0 3840500.0 False True 4246491.467489015 4374748.56296922 3443121.9006773266 1.0 1.0302030738698373 0.8108156879715274 22.017839920472635 -6.872111490022629 1.122932039429962 1.0173187220900552 0.7974447317407192 0.9667421867093444 0.017705570008319824 0.13484302526041875 0.31651597356206557 0.012220785111350196 0.0290426335268974 1.3424202971183602e-07 6.872111490022629 -0.21987399034933608 KFGYVDFESAEDLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFGYVDFESAEDLEK 15 1 P19338 P19338 NCL Nucleolin 0 19009900.0 5674500.0 2393400.0 10942000.0 False True 5494366.103564259 3349097.101416112 8075961.947036251 1.0 0.609551136252736 1.4698623635212953 22.389521613374523 -6.783320588426797 1.5229746320740092 0.7798711137809169 1.4773952562059982 0.7789491274007729 0.16536437727984163 0.24544999232960724 1.124673782518697 0.08550286691143363 0.2011947056021807 1.6469461964385463e-07 6.783320588426797 0.6975241424250813 KFGYVDFESAEDLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFGYVDFESAEDLEK 15 1 P19338 P19338 NCL Nucleolin 0 13376000.0 3239100.0 4989900.0 5147000.0 False True 4436682.8033861695 4769429.718607319 3931384.6057924205 1.0 1.074999031927004 0.8861090098196575 22.081049981995527 -6.799021539721806 1.4603847727566173 1.0414320116095042 0.8835783923178417 0.8291434187059071 0.032099356309816134 0.22216528372911595 0.9356058205047748 0.017294214742605257 0.04023557644170961 1.5884679633312085e-07 6.799021539721806 -0.15785361929166242 KFLDGIYVSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFLDGIYVSEK 11 1 P32969;D6RAN4;A0A2R8Y5Y7;H0Y9V9;H0Y9R4 P32969 RPL9 60S ribosomal protein L9 0 7531600.0 0.0 0.0 7531600.0 False True 0.0 0.0 6752302.280208666 0.0 KFLDGIYVSEK(ub)GTVQQADE ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFLDGIYVSEKGTVQQADE 19 2 P32969;A0A2R8Y5Y7;H0Y9V9;H0Y9R4 P32969 RPL9 60S ribosomal protein L9 1 11707400.0 4266900.0 5840700.0 1599800.0 True False 3548116.4057204234 5809234.989811828 1934310.783360549 1.0 1.6372729430313882 0.5451655363510541 21.75862191131961 -6.748551799831493 1.6554797266833592 1.3753745383957894 0.543266762567888 0.6426331073450116 0.26776725920737815 0.3025624915308165 1.63105946218722 0.12780494778466023 0.3107156520739286 1.7842191657485375e-07 6.748551799831493 -0.8321077758279014 KFLPGMAIGYSSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFLPGMAIGYSSSK 14 1 P19623;K7EQ47 P19623 SRM Spermidine synthase 0 63585800.0 18454100.0 18712600.0 26419100.0 False True 24193503.809758615 15920753.02114351 23685504.961901907 1.0 0.6580590040340402 0.9790026756003898 24.528116386109232 -10.532068824700676 8.804650975368524 1.0000137667728866 0.8185308402182528 0.2988714416457159 0.13102470525215776 3.541053829726182e-05 1.8819800903333726e-06 0.12687374021539174 0.042288041781945195 2.9371841456131385e-11 10.532068824700676 -0.18148292655463372 KFLPGMAIGYSSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFLPGMAIGYSSSK 14 1 P19623;K7EQ47 P19623 SRM Spermidine synthase 0 61094100.0 19904800.0 6076300.0 35113000.0 False True 19272933.019336686 8502598.277485898 25915851.93257938 1.0 0.44116784243245044 1.344676075332063 24.200072806704394 -6.739393369195539 1.6888231968056282 0.6672616386279491 1.345144577422385 0.6022304854891587 0.23480168572631563 0.3189277603952394 1.7857978720363508 0.10999677789346791 0.27011197685513466 1.8222444274688355e-07 6.739393369195539 0.6778829387944358 KFLPGMAIGYSSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFLPGMAIGYSSSK 14 1 P19623;K7EQ47 P19623 SRM Spermidine synthase 0 41858100.0 14117100.0 0.0 27741000.0 False True 21416672.798254084 0.0 22257979.19068777 1.0 0.0 1.0392827775051159 24.35223103084014 -10.488871905814463 5.01701901663813 1.0013098640176605 0.51964138875254 0.2216935533955977 0.424285417225063 0.0062318091226482766 0.0006348885807516969 0.4118377043366737 0.13693752957926864 3.244352947028692e-11 10.488871905814463 -0.4816684752651206 KFLPGMAIGYSSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFLPGMAIGYSSSK 14 1 P19623;K7EQ47 P19623 SRM Spermidine synthase 0 61269100.0 18454100.0 18222400.0 24592600.0 False True 25277079.47330086 17417274.114581447 18784334.38049554 1.0 0.6890540551956803 0.743137054276253 24.591326447632124 -10.541972517133454 6.295001184029081 1.0003714399785926 0.7160955547359708 0.9735042455023942 0.02207929191780247 0.00011524620237643077 8.38537813688191e-06 0.0214055303331782 0.007126060824475089 2.8709622554728562e-11 10.541972517133454 -0.2842758852426218 KFLPGMAIGYSSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFLPGMAIGYSSSK 14 1 P19623;K7EQ47 P19623 SRM Spermidine synthase 0 38498100.0 19904800.0 9206700.0 9386600.0 False True 16551723.132153092 9157101.679713132 11349294.661265243 1.0 0.5532415934341425 0.6856865941177024 23.98047808213867 -10.626723460470915 9.801226423082996 1.0000835271684942 0.6194640937759256 0.9167134754166298 0.054070445109548504 9.871062190982566e-05 3.759351783253477e-06 0.05236478882590931 0.017451161119275305 2.3619817600188574e-11 10.626723460470915 -0.38061943339256865 KFLPGMAIGYSSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFLPGMAIGYSSSK 14 1 P19623;K7EQ47 P19623 SRM Spermidine synthase 0 86031100.0 14117100.0 54563000.0 17351000.0 False True 18274864.239643592 51526521.08526825 14193296.036294317 1.0 2.819529623289456 0.7766567154849148 24.12335735293259 -6.671783444134653 1.9311375378963196 2.1596088534871662 0.7848592373436825 0.2869687651424576 0.7725790871579923 0.457013941409361 3.2875150580082715 0.3218865995730251 0.8579782158071356 2.1292004822488012e-07 6.671783444134653 -1.3747496161434838 KFLPLFDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFLPLFDR 8 1 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 0 64873000.0 23646000.0 11460000.0 29767000.0 False True 22895370.673166 16036037.763110505 21970129.709141657 1.0 0.7004052475073129 0.9595882950648731 24.44855258646298 -10.161363267551794 7.045007497710718 1.000000210017343 0.8299967717749966 0.3645308893641398 0.10581103608258809 3.4908283339565037e-07 4.138945405553936e-08 0.1024512218582803 0.034150365049401304 6.896626910829931e-11 10.161363267551794 -0.17000343824234643 KFLPLFDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFLPLFDR 8 1 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 0 135516000.0 25708000.0 95828000.0 13980000.0 False True 39000915.50654987 78726744.69241865 11216846.872348318 1.0 2.01858709391571 0.28760470688090756 25.217004654372502 -6.7472346455281915 1.6599270630576832 1.6009306675713653 0.2848499275934824 0.6370102191602556 0.42797393482148804 0.3049132868818769 1.6520751934030233 0.20374143813184306 0.49610328264251596 1.789638666583962e-07 6.7472346455281915 -1.3160807399778829 KFLPLFDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFLPLFDR 8 1 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 0 47092400.0 23646000.0 15650000.0 7796400.0 False True 19662696.695414748 15565690.343718223 9426591.19351932 1.0 0.7916355820790376 0.47941497239885505 24.228957861897257 -6.965274604008037 0.35330850442473855 1.0290466768792004 0.2314146920683754 0.9999186931428593 0.001929032557047786 0.07786790623622267 0.014532118274575258 0.004251010848267783 0.026778372465557622 1.0832417646464984e-07 6.965274604008037 -0.797631984810825 down KFLPLFDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFLPLFDR 8 1 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 0 92006000.0 25708000.0 29919000.0 36379000.0 False True 33279512.78044052 28253981.349085253 29758395.280061718 1.0 0.8489902341866934 0.8941956415164743 24.98813097646495 -10.035161966804925 7.722791443790035 1.0000000045430342 0.8715929378515839 0.9149522748990289 0.018455030262105657 1.4328143147036e-09 1.7239165164570343e-10 0.01786900674726006 0.005956335404907426 9.222274253485511e-11 10.035161966804925 -0.1284070666914503 KFMNPFNMPNLYQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFMNPFNMPNLYQK 14 1 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 0 22565100.0 1106900.0 7802200.0 13656000.0 False True 1432903.8702609949 7368000.711314993 11170748.122392664 1.0 5.142006288232689 7.795881045640542 20.450510395567864 -8.271324234195077 0.3219076528639422 2.675747828008515e-23 9.107708039857316 0.9985231678867346 0.1074679631401399 0.10671366891853062 0.08141686027651598 0.6966507468285208 0.76885681975248 5.3539679342954715e-09 8.271324234195077 9.107708039857316 KFNALFAQGNYSEAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFNALFAQGNYSEAAK 16 1 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 9011500.0 2922200.0 2381500.0 3707800.0 False True 2429938.7754098373 2368670.386809259 4483083.837069786 1.0 0.9747860360842859 1.8449369516784069 21.212488533556318 -6.900226940107009 0.959827427891022 0.9640462772699467 1.9366973277088282 0.9866787386423118 0.046672766272538815 0.11123924795489443 0.17647829214318012 0.03645402462172603 0.09495607691428011 1.2582677335452247e-07 6.900226940107009 0.9726510504388814 KFQSEK(ub)AAGSVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFQSEKAAGSVSK 13 2 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 19854200.0 3837900.0 5520300.0 10496000.0 True False 5822374.88807328 4535159.334699236 8421460.999439774 1.0 0.7789191561658433 1.4463962148316036 22.473176303280194 -6.817430411708348 1.3828641994382105 0.8805170312050393 1.460189971661133 0.8783808107925087 0.09681816814023882 0.19684924029600914 0.7403485485558438 0.05502591946210034 0.12692659364833217 1.5225430749243167e-07 6.817430411708348 0.5796729404560937 KFQSEK(ub)AAGSVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFQSEKAAGSVSK 13 2 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 7188900.0 1254100.0 3635200.0 2299600.0 True False 1717774.6607781816 3474584.8440011498 1756481.841748638 1.0 2.022724472153468 1.0225333286456335 20.712109364182343 -6.641005968899021 2.040998101767505 1.6682937792177703 1.026710125063128 0.15845138669810366 0.4374837572367209 0.5308033027062349 4.227296191861211 0.17448677781995053 0.4843921064985274 2.2855673905546857e-07 6.641005968899021 -0.6415836541546422 KFQSEK(ub)AAGSVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFQSEKAAGSVSK 13 2 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 6993900.0 2178900.0 3738300.0 1076700.0 True False 1811851.8916366082 3718161.0359055456 1301832.9919016769 1.0 2.052132987838762 0.7185096077173053 20.789033597592155 -6.696383149766455 1.843585961454295 1.6556444362489315 0.7227175897881062 0.40042810492311176 0.44442146630681634 0.40314173120590074 2.6612172173285056 0.19249451097303397 0.4973007984822863 2.011948455417512e-07 6.696383149766455 -0.9329268464608254 KFTFGLDWVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFTFGLDWVPK 11 1 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 0 19714000.0 6006100.0 7846300.0 5861600.0 False True 7874055.263155128 6675662.62463785 5255097.860437497 1.0 0.8478048986873528 0.6673940790113001 22.908675407246587 -6.968873601661747 0.2838033764432248 1.03796862621809 0.4717040851035243 0.9999722130972157 0.0007166062717984087 0.07666991577033114 0.01033231466534152 0.003261069514920433 0.016481431302275862 1.0743020348570793e-07 6.968873601661747 -0.5662645411145657 KFTFGLDWVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFTFGLDWVPK 11 1 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 0 25090700.0 11902000.0 5606200.0 7582500.0 False True 11524177.524825415 7844784.8959467765 5596415.779875923 1.0 0.6807240585323785 0.4856238779574602 23.458160454068103 -9.298953039846149 0.1133062057571825 1.6412877269006758 3.417920355845462e-12 0.9999299033373311 0.001775127173648161 0.7468876875381921 0.041330644531996995 0.365182226533689 0.21584201785044033 5.023969106379299e-10 9.298953039846149 -1.6412877268972579 KFTFGLDWVPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFTFGLDWVPK 11 1 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 0 81808000.0 22123000.0 23578000.0 36107000.0 False True 33562208.40794314 19370321.684245188 28970435.623739723 1.0 0.5771468149176033 0.863186214435261 25.000334313075193 -9.93154842371058 5.446748874809468 1.0000004239476776 0.7201665146754521 0.5606529423487465 0.11677509586183847 6.010512106046165e-07 1.181634882005056e-07 0.11306717054434241 0.03768900012655731 1.170716060536613e-10 9.93154842371058 -0.2798339092722255 KFTFGLDWVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFTFGLDWVPK 11 1 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 0 22848100.0 6006100.0 6530000.0 10312000.0 False True 8226717.478749552 6241483.008177674 7876517.982306477 1.0 0.7586844964957238 0.9574314424498378 22.97188546876948 -10.0192547909515 5.998802280888706 1.000000185701108 0.8580579696187295 0.40479015431544607 0.08113810092072547 2.0155120847194544e-07 3.2980245454795094e-08 0.07856173141982523 0.026187209467398997 9.566326714347048e-11 10.0192547909515 -0.14194221608237856 KFTFGLDWVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFTFGLDWVPK 11 1 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 0 26608400.0 11902000.0 5966200.0 8740200.0 False True 9897040.348000776 5934058.896402028 10567735.409881148 1.0 0.5995791355544712 1.0677672352842185 23.23856572950238 -6.680269056885083 1.901141769102873 0.7467081797342632 1.065980297212865 0.3252870070802696 0.16969812166790055 0.4379113203233371 3.0604042677110757 0.0716215654453244 0.18881743371732615 2.0880021576671138e-07 6.680269056885083 0.31927211747860174 KFTFGLDWVPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFTFGLDWVPK 11 1 P45974-2;P45974;Q92995;Q92995-2;H7C5J3 P45974-2;Q92995 USP5;USP13 Ubiquitin carboxyl-terminal hydrolase 5;Ubiquitin carboxyl-terminal hydrolase 13 0 83058000.0 22123000.0 36452000.0 24483000.0 False True 28638659.609525636 34423414.15611672 20027345.216794055 1.0 1.2019911066182367 0.6993115421551597 24.771460635167642 -6.797630296533865 1.4654746535605263 1.1117833453262165 0.6927637824195153 0.8251814054328689 0.08635391044558698 0.22415059748433885 0.950593980725909 0.04636125454966322 0.10798303815267793 1.5935647095236343e-07 6.797630296533865 -0.41901956290670117 KFVEDTK(ub)NEVHER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFVEDTKNEVHER 13 2 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 1 4570260.0 420360.0 1420600.0 2729300.0 True False 544164.3065343851 1341542.3611922364 2232595.4049828863 1.0 2.4653259044793043 4.102796486600893 19.053682803176827 -6.969688188871087 0.2655271524733489 0.5702196057579882 6.046838203133945 0.999979847892082 0.005689320073934021 0.07640400744536557 0.009391530722569725 0.033000515455520546 0.15325239937876875 1.0722889019702395e-07 6.969688188871087 5.476618597375957 KFVFFNIPQIQYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KFVFFNIPQIQYK 13 1 E7EPW2;P82663-3;P82663-2;P82663 E7EPW2 MRPS25 28S ribosomal protein S25, mitochondrial 0 17786000.0 5637000.0 9762500.0 2386500.0 False True 7390161.588785647 8305973.053926944 2139567.8729244745 1.0 1.1239230636757678 0.2895157091248459 22.81717447913417 -6.869112771679054 1.1387215773882196 1.0697300484597385 0.2414537468170475 0.9637926410612766 0.06995389322496268 0.13771142920929144 0.33428844927042833 0.04769963635207567 0.11276497555100351 1.351721520975597e-07 6.869112771679054 -0.8282763016426911 down KFVFFNIPQIQYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KFVFFNIPQIQYK 13 1 E7EPW2;P82663-3;P82663-2;P82663 E7EPW2 MRPS25 28S ribosomal protein S25, mitochondrial 0 25618700.0 12832000.0 6993500.0 5793200.0 False True 12424655.183881674 9786041.020620698 4275787.127725314 1.0 0.7876307934336872 0.3441372870671076 23.56670247805891 -6.959190929584149 0.44669014482487857 1.0147955827738593 0.09948783505988391 0.9997390048890125 0.004414289369854225 0.07999140872917769 0.022208817109351006 0.0058993637554691555 0.03670307038929886 1.0985227879113767e-07 6.959190929584149 -0.9153077477139754 down KFVFFNIPQIQYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFVFFNIPQIQYK 13 1 E7EPW2;P82663-3;P82663-2;P82663 E7EPW2 MRPS25 28S ribosomal protein S25, mitochondrial 0 31259700.0 9240100.0 7190600.0 14829000.0 False True 14017907.24179523 5907381.2495857775 11898041.650218396 1.0 0.42141677410823253 0.8487744600523301 23.74076764713751 -9.784825575776855 6.132284573457984 1.0000000128938815 0.6350956170798264 0.492927999518434 0.17446804470496094 3.07423093345074e-08 6.157304446430149e-09 0.16892796293061657 0.056309319298725624 1.641248810053021e-10 9.784825575776855 -0.3649043958140551 KFVFFNIPQIQYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KFVFFNIPQIQYK 13 1 E7EPW2;P82663-3;P82663-2;P82663 E7EPW2 MRPS25 28S ribosomal protein S25, mitochondrial 0 38741000.0 5637000.0 11058000.0 22046000.0 False True 7721151.234197107 10569420.996084021 16839188.851622257 1.0 1.368891849867139 2.1809168530518104 22.88038454065706 -6.958127624401737 0.4610705954302427 0.9765822658693983 2.6060192024176465 0.9996943077173277 0.008624738947666468 0.08037696663594521 0.02365547803643352 0.01104841777659202 0.06707365933151646 1.1012156520994681e-07 6.958127624401737 1.6294369365482482 up KFVFFNIPQIQYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KFVFFNIPQIQYK 13 1 E7EPW2;P82663-3;P82663-2;P82663 E7EPW2 MRPS25 28S ribosomal protein S25, mitochondrial 0 26086900.0 12832000.0 6135500.0 7119400.0 False True 10670376.553986384 6102446.843698596 8608033.623613639 1.0 0.5719054817628494 0.8067225725410537 23.347107753493187 -10.096991739472593 5.220637885538977 1.0000059984978826 0.6893140271515419 0.7000705127077054 0.0958636758833306 6.693128441324988e-06 1.157802429092177e-06 0.09282139571890324 0.030939868349991035 7.998494684529632e-11 10.096991739472593 -0.31069197134634075 KFVFFNIPQIQYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFVFFNIPQIQYK 13 1 E7EPW2;P82663-3;P82663-2;P82663 E7EPW2 MRPS25 28S ribosomal protein S25, mitochondrial 0 32766300.0 9240100.0 16018000.0 7508200.0 False True 11961491.59960124 15126584.219046373 6141784.64063771 1.0 1.264606850499368 0.5134631069625513 23.51189396922996 -6.811496822885527 1.4081420849838493 1.143956481647276 0.49985623310754995 0.8637184413360052 0.11484031248457287 0.20476829644908673 0.7999438798952287 0.06412012735716581 0.14823125108558002 1.5434877147855682e-07 6.811496822885527 -0.644100248539726 KFYLCLFSGPSTFIPEGLSENQDEVEPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KFYLCLFSGPSTFIPEGLSENQDEVEPR 28 1 O43709;O43709-3 O43709 WBSCR22 Probable 18S rRNA (guanine-N(7))-methyltransferase 0 124705000.0 27764000.0 39875000.0 57066000.0 False True 42120017.82028359 32758994.70520299 45786880.08708362 1.0 0.7777535813251093 1.0870574718758592 25.32800271095573 -6.713874877193317 1.7814066017554628 0.8639104773582326 1.0864160788675996 0.4834492719536917 0.09359903313669335 0.36735458973762225 2.274768623245505 0.04177579319836676 0.10563390210770608 1.932525008695181e-07 6.713874877193317 0.22250560150936705 KFYLCLFSGPSTFIPEGLSENQDEVEPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KFYLCLFSGPSTFIPEGLSENQDEVEPR 28 1 O43709;O43709-3 O43709 WBSCR22 Probable 18S rRNA (guanine-N(7))-methyltransferase 0 74746000.0 27764000.0 17666000.0 29316000.0 False True 35941045.31025947 16682871.570337918 23980788.807561737 1.0 0.46417324333011944 0.6672256914218451 25.09912903304818 -10.159087974626983 5.267611211207052 1.0000161507520382 0.5656994673757687 0.8591474519760225 0.08289581480870002 1.5723765161387862e-05 2.5102424265835715e-06 0.0802665085352871 0.026754509185257545 6.932853536257731e-11 10.159087974626983 -0.4343166833762695 KGAAVDGGK(ub)LDVGNAEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGAAVDGGKLDVGNAEVK 18 2 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 6132100.0 1416100.0 1586600.0 3129400.0 True False 1371146.680633951 2220137.654009697 2309716.260012362 1.0 1.6191831883246905 1.6845143503862494 20.386951483332517 -11.420625493820145 0.3820574789140676 5.369245064944556e-11 1.6910764482479992 0.999590490264149 0.006241691703354948 3.737026498203463 0.19264220372949747 3.1265066992409416 0.01757321245595342 3.796422216280123e-12 11.420625493820145 1.6910764481943068 KGAAVDGGK(ub)LDVGNAEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGAAVDGGKLDVGNAEVK 18 2 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 10345300.0 1664900.0 5448200.0 3232200.0 True False 2525775.0204938096 4475926.143019104 2593354.253276412 1.0 1.7721000907452258 1.0267558401814387 21.268294708341546 -10.35137307631913 4.1875758722869945 0.9992321719463267 1.3994279654702855 0.27688951928887995 0.30428551612299704 0.0021853418888981005 0.000338494584392437 0.29517304047528764 0.09820772803315743 4.4527357625568e-11 10.35137307631913 0.40019579352395873 KGAAVDGGK(ub)LDVGNAEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGAAVDGGKLDVGNAEVK 18 2 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 5038100.0 1416100.0 2118800.0 1503200.0 True False 1177549.8938669057 2107385.6038511298 1817512.1699884871 1.0 1.7896359337529015 1.5434693506022379 20.167356758766793 -10.34898326287284 6.40328578809738 0.9999547973178009 1.6665526421775563 0.9071989111820076 0.10049708674058909 6.485978670811227e-05 6.59419310916451e-06 0.09731243998441635 0.03243529527405526 4.4773055877942706e-11 10.34898326287284 0.6665978448597554 KGANEATK(ub)TLNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGANEATKTLNR 12 2 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 35819300.0 15332000.0 16602000.0 3885300.0 True False 12749237.322764905 16512561.730760997 4697698.266402511 1.0 1.2951803557124424 0.36846896386612477 23.603907609838785 -6.821021579681762 1.3674003065518499 1.1589400612479723 0.3477835431347206 0.8867237654615163 0.13009782526887434 0.19215960279789268 0.7057115103618721 0.0747590731887311 0.17226652153989702 1.5100051215746874e-07 6.821021579681762 -0.8111565181132517 down KGCTGVITLNRPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGCTGVITLNRPK 13 2 Q6NVY1;Q6NVY1-2;B8ZZZ0 Q6NVY1 HIBCH 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial 0 8295300.0 2358700.0 1831600.0 4105000.0 False True 3092278.541683289 1558332.4195208808 3680253.9779404867 1.0 0.5039430952014429 1.190143102677009 21.560238847385758 -6.712773190887518 1.785388317159455 0.6959032985812499 1.1886621037388199 0.47824775745340187 0.2089471507661347 0.36952043989526506 2.297774145759332 0.0930751324095728 0.23565676057391668 1.9374335191708301e-07 6.712773190887518 0.49275880515757 KGCVITISGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGCVITISGR 10 1 O00154-4;O00154-6;O00154-7;O00154;O00154-5;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 105479000.0 39599000.0 22118000.0 43762000.0 False True 51914672.47726143 18818080.615288716 39233928.0347458 1.0 0.3624809657333582 0.7557387182194054 25.629639004694337 -10.132734528893437 5.288266342199681 1.000011428772918 0.5591098419762618 0.6262922637653144 0.16054680516503772 2.1633536294097382e-05 3.5477091499826014e-06 0.15545280312402657 0.05181625855744637 7.366572562394604e-11 10.132734528893437 -0.44090158679665625 KGCVITISGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGCVITISGR 10 1 O00154-4;O00154-6;O00154-7;O00154;O00154-5;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 32597700.0 12376000.0 3310700.0 16911000.0 False True 11983130.654279912 4632679.775072418 12481501.780874623 1.0 0.3866001221824118 1.0415893927032092 23.51450153305303 -11.855726404616268 24.6226063846252 0.9208065354578864 0.742685281699048 0.0 0.3067850347596693 0.0 0.0 0.0 0.08904730834560148 1.3940347357134003e-12 11.855726404616268 -0.17812125375883836 KGCVITISGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGCVITISGR 10 1 O00154-4;O00154-6;O00154-7;O00154;O00154-5;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 62259000.0 18758000.0 25171000.0 18330000.0 False True 28457257.39349086 20679038.38807935 14707067.465675596 1.0 0.7266701109717393 0.516812539673609 24.762293291097997 -7.215581348039872 0.14260176622980894 1.2885760521530059 9.186617004442584e-10 0.9999970100415095 0.000342023689201289 0.09428772513991042 0.006679877026243766 0.019292901888083018 0.03861175053187066 6.087215149779513e-08 7.215581348039872 -1.2885760512343443 KGCVITISGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGCVITISGR 10 1 O00154-4;O00154-6;O00154-7;O00154;O00154-5;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 88835000.0 39599000.0 17678000.0 31558000.0 False True 54239820.42273747 16896927.50667149 24104650.357411522 1.0 0.31152255621385233 0.44440874194536956 25.692849066217228 -9.804836487668503 6.376444552507935 1.0000000148908945 0.3779656490866799 0.9669039961735496 0.05425055815194288 1.1495612690063972e-08 2.086797551843724e-09 0.052527878626335164 0.017509292353628334 1.5673410646019474e-10 9.804836487668503 -0.6220343658042147 KGCVITISGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGCVITISGR 10 1 O00154-4;O00154-6;O00154-7;O00154;O00154-5;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 31304900.0 12376000.0 7218900.0 11710000.0 False True 10291192.349761195 7180010.352860534 14158506.859077426 1.0 0.6976849823458158 1.3757887694525475 23.294906808487305 -6.785493782158772 1.5141510800860642 0.8300419897511316 1.382145791224948 0.7864407901751868 0.1281822279671197 0.2421337719951609 1.0966751993778698 0.06665099864914399 0.1565829909672488 1.638725522927831e-07 6.785493782158772 0.5521038014738163 KGCVITISGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGCVITISGR 10 1 O00154-4;O00154-6;O00154-7;O00154;O00154-5;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 68455000.0 18758000.0 30112000.0 19585000.0 False True 24282600.775459144 28436240.729424674 16020730.959070051 1.0 1.171054163117624 0.6597617408124243 24.533419613190446 -6.816491772193304 1.3869591483010821 1.092536966515299 0.6494153460392766 0.876129638704587 0.07479309255589502 0.1980794616434885 0.7496383063515107 0.04238611105622634 0.09779748290284133 1.525837301864731e-07 6.816491772193304 -0.44312162047602244 KGDECELLGHSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGDECELLGHSK 12 1 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 6663500.0 2633400.0 786500.0 3243600.0 False True 2549804.15845028 1100553.551543316 2394003.854085796 1.0 0.43162277694778356 0.9388971486895777 21.281955012297427 -10.41482524222068 8.720278513644287 1.0000024835054921 0.6852599628186822 0.3391850676985332 0.20709389505971762 9.999265205739934e-06 6.709068688676492e-07 0.20051938478774511 0.06683926722229272 3.8474657086479385e-11 10.41482524222068 -0.31474252068680997 KGDECELLGHSK(ub)NIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGDECELLGHSKNIR 15 2 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 1 2692710.0 600810.0 794800.0 1297100.0 True False 787667.7282523173 676218.9381061348 1162888.5346617773 1.0 0.8585078629621327 1.4763694041928093 19.58722764232018 -6.846470427028351 1.251978303265249 0.9246645016638106 1.4994411166699984 0.9350161061302997 0.06737574610473754 0.16137996667768922 0.4885473540317124 0.0421459758907834 0.09733490186210586 1.424064213977301e-07 6.846470427028351 0.5747766150061877 KGDECELLGHSK(ub)NIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGDECELLGHSKNIR 15 2 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 1 3284050.0 739450.0 587400.0 1957200.0 True False 715976.5645044659 821951.8832505324 1444550.6052585787 1.0 1.1480150664140985 2.0175948164705164 19.44955284010159 -6.936282659889355 0.6932871025038272 0.9893338554474153 2.2284894881317387 0.9976352971686876 0.021829056706212817 0.08950416762215756 0.06264439623217079 0.020692160026394485 0.07614896761422313 1.158023413089691e-07 6.936282659889355 1.2391556326843234 up KGDECELLGHSK(ub)NIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGDECELLGHSKNIR 15 2 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 1 15521600.0 2270500.0 3922700.0 9328400.0 True False 3444514.495784252 3222663.536805013 7484637.651217042 1.0 0.9355929669476605 2.1729151264648485 21.71586921876022 -6.894626569748746 0.9946364624641085 0.9407014221330944 2.289495795980058 0.983697289735105 0.07261362799051659 0.11546860219695602 0.20057388523038588 0.05526140571311464 0.14026820705266194 1.2745985798365377e-07 6.894626569748746 1.3487943738469634 up KGDECELLGHSK(ub)NIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGDECELLGHSKNIR 15 2 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 1 2335650.0 600810.0 510440.0 1224400.0 True False 822945.6932797539 487887.0730006452 935221.9373095473 1.0 0.5928545188154862 1.1364321424203943 19.65043770384307 -6.706246613248318 1.8086890731540615 0.7487425835401098 1.1350142426096261 0.4472447451080801 0.17167279060312232 0.3826533727601251 2.437768058405461 0.07560293533002584 0.1929387111215743 1.966769146647779e-07 6.706246613248318 0.3862716590695163 KGDECELLGHSK(ub)NIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGDECELLGHSKNIR 15 2 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 1 3557250.0 739450.0 1477900.0 1339900.0 True False 614885.4381893106 1469938.2593598196 1620066.895002376 1.0 2.390588828527853 2.6347459126257444 19.229958115535865 -10.40021268135577 0.3696130925032727 3.9662213158194156e-15 2.670876154062126 0.999133558747853 0.021193796056660656 1.850026873992086 0.17380866600862835 1.8564894709942674 0.06793092804387865 3.979122584661302e-11 10.40021268135577 2.670876154062122 KGDECELLGHSK(ub)NIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGDECELLGHSKNIR 15 2 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 1 14110900.0 2270500.0 3290100.0 8550300.0 True False 2939207.008246081 3107003.042769664 6994233.133486678 1.0 1.0570888794334061 2.3796327083679487 21.486995540852668 -6.915954855651546 0.854183896877345 0.9663523720878663 2.574254330590869 0.9929816173521105 0.05339327516987088 0.10061084147987581 0.11837785762204629 0.04504417933472474 0.13012597919672933 1.2135149872189298e-07 6.915954855651546 1.6079019585030028 up KGDIIQLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGDIIQLQR 9 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 7942080.0 401480.0 3657100.0 3883500.0 False True 526344.1679378508 3111474.935264147 3481672.6731624524 1.0 5.9114836352315026 6.614821413910979 19.005646937462966 -9.629225383418591 0.5396975979388527 3.293114556463756e-17 6.576986222870394 0.9987997246470018 0.08653050139837597 0.9272255726960276 0.24056234143101005 1.957448801290682 0.1325659364299219 2.348413761178297e-10 9.629225383418591 6.576986222870394 KGDIIQLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGDIIQLQR 9 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 8342380.0 401480.0 4089700.0 3851200.0 False True 549918.005589047 3909003.5311706355 2941625.8779537096 1.0 7.1083388640520875 5.349208151136595 19.068856998985858 -10.018501018794373 8.297883967197581 0.9999999625050734 6.228773507594341 0.9217522211961527 0.7181621062502266 4.964399537182667e-07 5.993798176140356e-08 0.6953574693457331 0.2317858231153641 9.582944682783718e-11 10.018501018794373 5.228773545089267 KGDIVDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGDIVDIK 8 1 P46778;G3V1B3;M0R181 P46778 RPL21 60S ribosomal protein L21 0 47499600.0 1541300.0 44403000.0 1555300.0 False True 2338264.784123438 36478937.727777556 1247894.2732877925 1.0 15.600858369619024 0.5336839017381 21.15700687862576 -6.623599699444633 2.103476241745085 9.999999999999782 0.592378675973545 0.23198692285143008 6.130525234860532 0.5057008025995662 4.256096574121494 2.4367037352562484 6.926603497482389 2.3790320922994607e-07 6.623599699444633 -9.407621324026236 KGDIVDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGDIVDIK 8 1 P46778;G3V1B3;M0R181 P46778 RPL21 60S ribosomal protein L21 0 6137700.0 1541300.0 3217900.0 1378500.0 False True 1995243.2335651543 3038821.0362385632 1127627.1446044433 1.0 1.5230328739462586 0.5651577339718972 20.92813320071821 -6.758447528912996 1.61842954410637 1.3043941073148633 0.5619382070846038 0.684554657686338 0.21994193179699512 0.2855327228332612 1.4736987282640315 0.10724592981796449 0.25811363229313344 1.744024056228765e-07 6.758447528912996 -0.7424559002302594 KGDIVDIK(ub)GMGTVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGDIVDIKGMGTVQK 15 2 P46778;G3V1B3;M0R181 P46778 RPL21 60S ribosomal protein L21 1 8806100.0 1036300.0 1799700.0 5970100.0 True False 1003403.223741942 2518329.595311517 4406351.710839076 1.0 2.5097882244388603 4.391406771055296 19.93647004764869 -6.96815332858477 0.2990221852885354 0.6698489870588369 6.290223284246204 0.9999641836730772 0.008302579148044224 0.07690655525031785 0.011163415000792199 0.03136902734170114 0.16892960131489876 1.0760852323914595e-07 6.96815332858477 5.620374297187366 KGDIVDIK(ub)GMGTVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGDIVDIKGMGTVQK 15 2 P46778;G3V1B3;M0R181 P46778 RPL21 60S ribosomal protein L21 1 5552900.0 1036300.0 3414300.0 1102300.0 True False 861729.3658740731 3395906.4882145124 1332785.8335406503 1.0 3.9408039492421865 1.5466408437743944 19.716875323082967 -6.595223654320922 2.209512433729144 2.9838660865869153 1.5541243424925075 0.00695773474796757 1.2726624474609103 0.6542834657822533 6.029781864260024 0.4794844050020708 1.4164442645186583 2.5396644844196244e-07 6.595223654320922 -1.4297417440944078 KGDSSAEELK(ub)LATQLTGPVMPVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGDSSAEELKLATQLTGPVMPVR 23 2 P26373;P26373-2 P26373 RPL13 60S ribosomal protein L13 1 13969900.0 5882700.0 3352500.0 4734700.0 True False 4891725.697797354 3334439.417080855 5724703.879220653 1.0 0.6816488951092017 1.1702830928967198 22.22191207672124 -6.730879337883571 1.719993161950764 0.8086070219782573 1.1700413855941032 0.5633641835943111 0.1338180339608401 0.33458589406109096 1.939563918985534 0.061644226256445396 0.15281570958552668 1.8583206895140363e-07 6.730879337883571 0.3614343636158459 KGDVVIVLTGWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGDVVIVLTGWR 12 1 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 13625800.0 4736200.0 4482800.0 4406800.0 False True 6209204.065426046 3813983.7138175396 3950826.609010508 1.0 0.6142467977585856 0.6362855154027574 22.56597691595719 -10.333640573284502 5.712276387202675 1.0000585185691804 0.6252661565806711 0.9974126028195167 0.008997268802256056 6.70630122063116e-06 7.823079785283259e-07 0.008712923275665259 0.0029038560193730563 4.63830632078568e-11 10.333640573284502 -0.3747923619885093 KGDVVIVLTGWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGDVVIVLTGWR 12 1 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 25299900.0 11186400.0 7078000.0 7035500.0 False True 10831293.855125776 9904282.31128238 5192691.489524176 1.0 0.9144135911883972 0.47941562282208783 23.36870225497673 -6.939440519963743 0.6647478846428756 1.0049329007916337 0.3640162385581065 0.9980896999690824 0.009961997952255696 0.08802279994125439 0.05577892063209549 0.00965663530818446 0.03753264025172692 1.1496336839899165e-07 6.939440519963743 -0.6409166622335272 down KGDVVIVLTGWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGDVVIVLTGWR 12 1 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 23712700.0 4518100.0 7717600.0 11477000.0 False True 6854288.017354241 6340333.982115981 9208565.919452205 1.0 0.925017152191885 1.3434751933588454 22.708575384536736 -6.860552780734382 1.182817175183234 0.9592514298642515 1.3639657012439852 0.9543167449662721 0.038938421208983866 0.14624000768736492 0.3884423886670377 0.02566869707872382 0.059961050655067454 1.3786283951388805e-07 6.860552780734382 0.4047142713797337 KGDVVIVLTGWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGDVVIVLTGWR 12 1 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 18861500.0 4736200.0 6600000.0 7525300.0 False True 6487301.13099244 6308390.1767186355 5747979.128418434 1.0 0.9724213581794323 0.8860355041880256 22.62918697748008 -6.950476977061871 0.5535906721250498 1.0011700449832452 0.8532035217825977 0.9992381152834953 0.0013399850605628604 0.08329493807823808 0.035175269065806244 0.0014477694334318412 0.007171416677877513 1.1207868400210097e-07 6.950476977061871 -0.14796652320064752 KGDVVIVLTGWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGDVVIVLTGWR 12 1 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 19697100.0 11186400.0 5961600.0 2549100.0 False True 9301987.241545608 5929483.677515055 3082105.024293276 1.0 0.6374426801008833 0.33133834139522605 23.149107530411005 -7.585558882021195 0.2417757621338681 1.1489480378082362 1.479362981956042e-17 0.9998530362617812 0.003313222132303414 0.12986265383430906 0.026950664281939977 0.03318413165251357 0.07191174494217106 2.5968156390247406e-08 7.585558882021195 -1.1489480378082362 down KGDVVIVLTGWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGDVVIVLTGWR 12 1 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 21740700.0 4518100.0 12823000.0 4399600.0 False True 5848769.515065667 12109388.777677078 3598917.9437081716 1.0 2.0704164776000957 0.6153290763874056 22.479701706629186 -6.70954033285565 1.7966032343319787 1.6583502340788683 0.6187459685571531 0.4630993556848564 0.4510963085125189 0.37596097491381375 2.3652138965561798 0.19982156951142352 0.5079695119211662 1.9519094521223795e-07 6.70954033285565 -1.039604265521715 KGDVVIVLTGWRPGSGFTNTMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 KGDVVIVLTGWRPGSGFTNTMR 22 2 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 245168590.0 67348690.0 111740400.0 66079500.0 False True 88294784.79564182 95069167.88066785 59242227.219322294 1.0 1.076724611772998 0.6709595289963995 26.39582489062815 -6.857776828480334 1.196889627946505 1.0414071042354638 0.6521259215699294 0.9508829502317552 0.03900685629736116 0.1491105370158938 0.4071621344385682 0.025440388874252574 0.059245769825292734 1.3874686261784414e-07 6.857776828480334 -0.38928118266553435 KGDVVIVLTGWRPGSGFTNTMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 KGDVVIVLTGWRPGSGFTNTMR 22 2 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 890167500.0 283779300.0 283953300.0 322434900.0 False True 274770881.45443547 397337333.4868976 237979526.85034165 1.0 1.4460678343486952 0.8661016974966657 28.03365388331625 -6.701198960868048 1.8261392139725925 1.2766494834373983 0.8677588731057418 0.42354129481741076 0.18824776670441679 0.39299956889790194 2.548653138012716 0.08220528050039697 0.21113364847955982 1.9897615719670644e-07 6.701198960868048 -0.4088906103316564 KGDVVIVLTGWRPGSGFTNTMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 KGDVVIVLTGWRPGSGFTNTMR 22 2 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 5598213700.0 1018410700.0 2141714000.0 2438089000.0 False True 1545003487.6951263 1759508403.412143 1956199640.4976304 1.0 1.1388378197365887 1.2661457764188846 30.524962948863344 -6.972162039737112 0.19991104337813984 0.9241362118555501 1.484362010603207 0.9999946963528609 0.000250236988695836 0.07560724914213053 0.006454140061836352 0.004136303256959207 0.013518347168068694 1.0661982374813368e-07 6.972162039737112 0.5602257987476569 KGDVVIVLTGWRPGSGFTNTMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 KGDVVIVLTGWRPGSGFTNTMR 22 2 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 563332290.0 67348690.0 205170600.0 290813000.0 False True 92249320.72291279 196105484.48355564 222128958.88173884 1.0 2.1258203631937116 2.4079197238637953 26.45903495215104 -10.416128854216115 0.2990335051093522 3.626993115588959e-24 2.5001315051501445 0.9990513353828325 0.0187331519509554 1.9486143440868362 0.14328232731488402 1.603506598192049 0.10139522879736736 3.835934172848971e-11 10.416128854216115 2.5001315051501445 KGDVVIVLTGWRPGSGFTNTMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 KGDVVIVLTGWRPGSGFTNTMR 22 2 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 636114400.0 283779300.0 150980200.0 201354900.0 False True 235975061.5045722 150166839.69537655 243457278.63013205 1.0 0.6363674141577327 1.0317076604529876 27.814059158750528 -6.664892402726804 1.9557310470451064 0.7668833318597821 1.030071701928596 0.25657663384083385 0.15464721081669489 0.4729148675470796 3.4822379603957363 0.06377583476890356 0.17152032050290306 2.1632544076817493e-07 6.664892402726804 0.263188370068814 KGDVVIVLTGWRPGSGFTNTMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 KGDVVIVLTGWRPGSGFTNTMR 22 2 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 4475039900.0 1018410700.0 2037981900.0 1418647300.0 False True 1318352727.0261154 1924566415.7349315 1160468047.9505284 1.0 1.4598266277920078 0.8802409432324408 30.296089270955793 -6.695269210571434 1.8474759683811417 1.286842347552319 0.8820947800633715 0.3952834177873288 0.19427091911012936 0.40544514994355224 2.6868932805197496 0.08399304945843096 0.21729961188522917 2.0171156059382165e-07 6.695269210571434 -0.40474756748894747 KGEFETGFEK(ub)GGQTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGEFETGFEKGGQTR 15 2 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 1 16516100.0 6231900.0 7266500.0 3017700.0 True False 8170081.249805455 6182366.524595146 2705457.35182241 1.0 0.7567080835019064 0.33114203752708476 22.96191899507684 -6.962577999241337 0.3974343550458406 1.0240662856481086 0.04830899297334459 0.9998541886366599 0.0033378230684700722 0.07879273795119189 0.017820422326939873 0.005478309508411967 0.035690186859499394 1.089988712951323e-07 6.962577999241337 -0.9757572926747641 down KGEFETGFEK(ub)GGQTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGEFETGFEKGGQTR 15 2 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 1 27167600.0 10467000.0 7571800.0 9128800.0 True False 10134730.814346127 10595259.22641538 6737693.421870273 1.0 1.0454406160859602 0.6648122723035516 23.27280443451952 -6.87709795347115 1.0959098048593636 1.0272117638750466 0.6393002631219563 0.9712657942020163 0.02877227702999892 0.13022921545413096 0.2881146352242739 0.020274951638292463 0.04868621719215523 1.327095102711072e-07 6.87709795347115 -0.38791150075309033 KGEFETGFEK(ub)GGQTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGEFETGFEKGGQTR 15 2 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 1 50939000.0 18494000.0 12098000.0 20347000.0 True False 28056750.092505556 9939017.377894573 16325406.531593082 1.0 0.3542469225810104 0.5818709037136087 24.741844570640314 -10.158159555835859 5.299886822611265 1.0000183740316246 0.4680589131471265 0.8792511099179253 0.09292710116675401 2.0175696236043545e-05 3.204684612809798e-06 0.08997938208626033 0.029992092935733187 6.947690188868584e-11 10.158159555835859 -0.5319594608844982 KGEFETGFEK(ub)GGQTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGEFETGFEKGGQTR 15 2 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 1 16579800.0 6231900.0 5518800.0 4829100.0 True False 8536001.840765128 5274961.167768906 3688566.038436406 1.0 0.6179662640860071 0.43211870232045074 23.02512905659973 -13.999999999953124 0.094794461782253 2.9191701278415945 0.0022844748060703987 0.9998194701052819 0.003176341577443991 12.122092889223238 0.09059617766086836 4.616813476924792 0.38467217865170983 1.0000000001079367e-14 13.999999999953124 -2.916885653035524 KGEFETGFEK(ub)GGQTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGEFETGFEKGGQTR 15 2 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 1 30156100.0 10467000.0 15549000.0 4140100.0 True False 8703774.266721904 15465234.450765163 5005775.768340422 1.0 1.7768423188426532 0.5751270213290749 23.053209709953798 -6.732195767651823 1.7154680548058128 1.4663485451127656 0.5755738407324816 0.5693748056557829 0.32651100136550704 0.3321018071834554 1.9156827903685394 0.1507797228030127 0.3731882986588274 1.8526962921429475e-07 6.732195767651823 -0.8907747043802839 KGEFETGFEK(ub)GGQTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGEFETGFEKGGQTR 15 2 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 1 58120000.0 18494000.0 15568000.0 24058000.0 True False 23940847.57124111 14701627.114628159 19679690.855925802 1.0 0.614081313156534 0.8220131220235488 24.512970892732763 -10.136755279120786 5.764037997348727 1.0000029812677385 0.7180472175900258 0.710279304053008 0.08488780550307307 3.2522800942853995e-06 4.870213747449199e-07 0.08219313370762024 0.027397421417449924 7.298686685710727e-11 10.136755279120786 -0.2819557636777127 KGELSIIPYEITLLSPCLHMLPHLHFGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGELSIIPYEITLLSPCLHMLPHLHFGLK 29 1 Q15046;Q15046-2;H3BVA8;J3KRL2;H3BPV7 Q15046 KARS Lysine--tRNA ligase 0 3782530000.0 750220000.0 1503410000.0 1528900000.0 False True 1138138588.4286542 1235114739.3040564 1226712244.8593256 1.0 1.0852059247101797 1.077823261008098 30.08402909587073 -10.139224575022082 4.709008942360147 0.9999927916460221 1.0815145928599579 0.9938855880556833 0.0030139598382536155 2.2811154996279356e-07 4.169193545347749e-08 0.0029185121116024958 0.0009727513545766425 7.257305828570558e-11 10.139224575022082 0.08152180121393582 KGELSIIPYEITLLSPCLHMLPHLHFGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 KGELSIIPYEITLLSPCLHMLPHLHFGLK 29 1 Q15046;Q15046-2;H3BVA8;J3KRL2;H3BPV7 Q15046 KARS Lysine--tRNA ligase 0 2863412000.0 940445000.0 1027851000.0 895116000.0 False True 1217424591.4424062 970650188.2963554 732214072.6657617 1.0 0.7972979970334982 0.6014451143936838 30.181185267015568 -6.971545075014195 0.21815065245761944 1.0924545806749222 0.3007700437287237 0.9999920544595811 0.0004586286683930519 0.07580449890078163 0.00720890376489079 0.005502585807326529 0.019929232506514776 1.067713969763368e-07 6.971545075014195 -0.7916845369461984 KGEPHHELPPGSTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGEPHHELPPGSTKR 15 2 P04637;P04637-4;P04637-3;P04637-2;P04637-6;P04637-5;J3KP33;A0A0U1RQC9;A0A087WZU8;P04637-7;E7ESS1;P04637-9;P04637-8;A0A087WT22;A0A087WXZ1;A0A087X1Q1 P04637 TP53 Cellular tumor antigen p53 1 7165900.0 1442900.0 1934000.0 3789000.0 True False 1397095.9293035283 2706256.285676761 2796547.2324365135 1.0 1.9370583142604012 2.001685907016157 20.413999653764446 -10.999901320508794 0.47536086923709436 1.0667527974636983e-21 2.0004870016355456 0.9997292664770341 0.0075314368016154406 2.809313323375261 0.23098349563741521 3.0884265382062615 0.013787562086964847 1.000227243741383e-11 10.999901320508794 2.0004870016355456 KGEQELAEVK(ub)VEAIPNCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGEQELAEVKVEAIPNCK 18 2 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 78913200.0 29786000.0 30970000.0 18157200.0 True False 39049734.448034264 26349396.72011446 16278467.120161008 1.0 0.6747650679975589 0.4168649889751159 25.218809401777083 -7.49259823380319 0.1880672745914653 1.2187382539778795 2.7111880669667662e-11 0.9999630717158621 0.0014498817385233949 0.12879266873413941 0.017043881992442642 0.033143635719538954 0.0654165240824075 3.2166348743224795e-08 7.49259823380319 -1.2187382539507676 down KGEQELAEVK(ub)VEAIPNCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGEQELAEVKVEAIPNCK 18 2 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 43887700.0 17055000.0 9794800.0 17037900.0 True False 25873681.88751396 8046841.412878304 13670351.597023133 1.0 0.3110048831806007 0.5283496819839981 24.62498203183665 -10.063643266763405 5.237239312224241 1.0000072401118953 0.4196772825814096 0.9048126396079434 0.08873064255638738 52461185.67246588 100807046.50768855 3006.8815033380224 0.03037486376862609 8.636876970067731e-11 10.063643266763405 -0.5803299575304857 KGEQELAEVK(ub)VEAIPNCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGEQELAEVKVEAIPNCK 18 2 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 66257000.0 29786000.0 24100500.0 12370500.0 True False 40798689.1363837 23035660.220304135 9448842.67844475 1.0 0.5646176558099573 0.23159672230788428 25.282019463299974 -7.973142401792971 0.2862699935730519 1.1350021471760388 2.997451076985956e-18 0.9993521716897638 0.008008001162792025 0.10251144108808478 0.053007373087008584 0.05839993628897743 0.0906522435781572 1.0637941511788393e-08 7.973142401792971 -1.1350021471760388 down KGEQELAEVK(ub)VEAIPNCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGEQELAEVKVEAIPNCK 18 2 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 23839900.0 17815200.0 3193100.0 2831600.0 True False 14814128.147177255 3175898.1365192756 3423674.4681608523 1.0 0.21438306088397274 0.23110873850603306 23.820470386375998 -10.06086683991611 5.844149884169218 1.0000025242250135 0.22274589969492206 0.9996528220214148 0.0068282292963425485 2.2456993207195087e-07 3.60752289455002e-08 0.006611426056112185 0.002203801529026478 8.692269042001836e-11 10.06086683991611 -0.7772566245300914 KGEQELAEVK(ub)VEAIPNCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGEQELAEVKVEAIPNCK 18 2 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 41829200.0 17055000.0 12687000.0 12087200.0 True False 22078033.704310477 11980957.297230702 9887453.625145322 1.0 0.5426641456250499 0.4478412234335394 24.3961083539291 -13.999999999999998 0.2211602076101938 3.7738819077712797 0.397680679564229 0.9994990813316343 0.0053954052542311195 13.031435983234985 0.1489713889661117 15.796590184674097 0.0520786435107805 1.0000000000000041e-14 13.999999999999998 -3.3762012282070506 KGESGQSWPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGESGQSWPR 10 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 18119500.0 664500.0 8736600.0 8718400.0 False True 871165.9350271535 7433133.335000071 7816303.600798132 1.0 8.532396683725226 8.972232827899205 19.732588016269133 -9.769761013496886 0.7272458119446755 1.648302773353958e-23 8.893437081008639 0.999632682414278 0.0701244734437722 1.0576700465463515 0.36239397827953945 2.816734329450447 0.06665724708929842 1.6991784306325297e-10 9.769761013496886 8.893437081008639 KGESGQSWPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGESGQSWPR 10 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 15030900.0 4330600.0 1614700.0 9085600.0 False True 4193127.4734505937 2259458.130549263 6705808.797842499 1.0 0.5388479469931111 1.5992380008242817 21.999595258921683 -6.788506177675402 1.502260779763019 0.7417583985042894 1.6100608819699567 0.7964487340401105 0.1958623266975473 0.237591821767456 1.0592891905606963 0.10263100831054738 0.24055205092448412 1.6273981663517292e-07 6.788506177675402 0.8683024834656673 KGESGQSWPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGESGQSWPR 10 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 20837700.0 664500.0 10435000.0 9738200.0 False True 910183.6074372857 9973947.19606952 7438237.724524529 1.0 10.958170543361224 8.172238726060604 19.795798077792025 -9.825390830913369 9.178543062613823 1.0000000242716978 9.565204632318954 0.9264866977930599 1.1373519017618614 0.0 0.0 1.1012362763946528 0.36707874785841843 1.4948897672436407e-10 9.825390830913369 8.565204608047257 KGFDQEEVFEK(ub)PTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGFDQEEVFEKPTR 14 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 16188400.0 3661500.0 2174900.0 10352000.0 True False 3545267.686703772 3043348.911953672 7640500.646656853 1.0 0.8584257045998236 2.1551265861565003 21.757463132106302 -6.879839457841902 1.0806596420988306 0.9124330343026341 2.246753222726031 0.9735571982041236 0.09444274912783716 0.1277739912888582 0.2731271765666995 0.06732934140039269 0.16275808634046784 1.3187441380335527e-07 6.879839457841902 1.3343201884233968 up KGFDQEEVFEK(ub)PTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGFDQEEVFEKPTR 14 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 138987000.0 12040000.0 25517000.0 101430000.0 True False 18265560.24190372 20963291.984769005 81382316.04165168 1.0 1.1476949903062004 4.455506152773207 24.12262266898295 -6.916248135914517 0.8520955320912661 0.916689118846897 4.945447005691611 0.9930735547829888 0.13276669738757202 0.10042975293672932 0.11742731608437489 0.11217501615366901 0.32485344052823106 1.212695773836496e-07 6.916248135914517 4.028757886844715 up KGFDQEEVFEK(ub)PTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGFDQEEVFEKPTR 14 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 16795900.0 3551700.0 5436900.0 7807300.0 True False 4864859.471083538 5196679.780575982 5963376.536390736 1.0 1.0682075836855651 1.2258065360030899 22.21396670047669 -6.957127173005158 0.4741907104910012 0.9960024620941264 1.3045182333192265 0.9996483601880382 0.0017732290996555842 0.08074378967449358 0.02504769174768426 0.002196592443868387 0.013004029146210381 1.1037553635722544e-07 6.957127173005158 0.3085157712251001 KGFDQEEVFEK(ub)PTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGFDQEEVFEKPTR 14 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 15864800.0 3661500.0 5542300.0 6661000.0 True False 3044699.4819530225 5512442.529839583 8053784.30301576 1.0 1.8105046368331978 2.645182012462412 21.53786840754058 -6.970757136092733 0.23941370806458537 0.6981034178495413 3.781707492081399 0.9999877003016866 0.0023555909560932634 0.07605778937245529 0.008146046479058772 0.020035003532930872 0.0814576946155882 1.0696528777357222e-07 6.970757136092733 3.083604074231858 KGFDQEEVFEK(ub)PTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGFDQEEVFEKPTR 14 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 139652000.0 12040000.0 23532000.0 104080000.0 True False 15586017.343881441 22222423.513709523 85138507.95098346 1.0 1.425792299816304 5.46249282754751 23.893748991075398 -6.927081318137872 0.7703705426582427 0.9315128017038625 6.2328051874080925 0.995932860591405 0.12823744420437697 0.09418211617856546 0.08531362742156183 0.1148622291713422 0.371286783511967 1.1828200614757235e-07 6.927081318137872 5.30129238570423 up KGFGDPFSGKDPFVPSSAAK(ub)PSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGFGDPFSGKDPFVPSSAAKPSK 23 3 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 37481500.0 2669200.0 4101700.0 30710600.0 True False 3499347.0485695703 3489742.348301371 27532961.70887676 1.0 0.9972552878765982 7.868028328350976 21.738654320618615 -6.906804529991868 0.9172289480112936 0.765173357918246 8.697822606732359 0.9896584759707269 0.32930997865217326 0.10656927148154983 0.1505137521055782 0.26542061146053597 0.7174242917611885 1.2393542774308265e-07 6.906804529991868 7.932649248814113 up KGFGDPFSGKDPFVPSSAAK(ub)PSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGFGDPFSGKDPFVPSSAAKPSK 23 3 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 89101100.0 32756600.0 4544400.0 51800100.0 True False 31716759.663056303 6359002.618732933 38232099.84031 1.0 0.2004934516100616 1.2054226297537818 24.91874205010739 -6.69476990946809 1.8496434675220514 0.5010068662707008 1.2021438753600135 0.39272454250223343 0.33781652156893255 0.40651446575393946 2.70003169682788 0.14591674673100338 0.37768399049657564 2.0194359836132175e-07 6.69476990946809 0.7011370090893128 KGFGDPFSGKDPFVPSSAAK(ub)PSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGFGDPFSGKDPFVPSSAAKPSK 23 3 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 248416500.0 95060000.0 97589200.0 55767300.0 True False 144212969.81689087 80173644.79210028 44744868.71132415 1.0 0.5559392119439592 0.3102693798493804 27.10362567852558 -9.25967326658981 0.17507729381939174 1.4952015795700413 3.6465223328634534e-21 0.9996920684731394 0.005008850610704352 0.6926678191193879 0.06333449994507977 0.3410379506156503 0.1592273654694256 5.499544663162085e-10 9.25967326658981 -1.4952015795700413 KGFGDPFSGKDPFVPSSAAK(ub)PSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGFGDPFSGKDPFVPSSAAKPSK 23 3 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 29761200.0 2669200.0 3991400.0 23100600.0 True False 3656075.3724177643 3815046.7502052668 17644714.051791016 1.0 1.0434814279231817 4.826135200851332 21.801864382141506 -6.909409305149339 0.8997313381364135 0.8806819272819039 5.308880416987686 0.990697128194421 0.17298525169699572 0.10481038670064784 0.14088933732536554 0.1412129501592295 0.3882428479172529 1.2319432287963007e-07 6.909409305149339 4.428198489705783 up KGFGDPFSGKDPFVPSSAAK(ub)PSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGFGDPFSGKDPFVPSSAAKPSK 23 3 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 137649000.0 95060000.0 15317000.0 27272000.0 True False 123057043.91273826 14464595.485274874 22308775.83435066 1.0 0.11754382378575542 0.18128808498089857 26.87475200061803 -10.205367286807679 6.104569878019322 1.0000119901966884 0.14941595440837654 0.995805468013756 0.026023485659811118 4.246767194280509e-06 5.527682923583197e-07 0.02519748610715276 0.008399043880891242 6.232075602306397e-11 10.205367286807679 -0.8505960357883119 KGFPHVIYAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGFPHVIYAR 10 1 K7EIU8;Q13485;K7EL15;K7EL18;K7EIJ2;K7ES96 K7EIU8 SMAD4 Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 4 0 2654780.0 1183100.0 635780.0 835900.0 False True 1551055.5571566978 540924.1022510289 749409.0865189885 1.0 0.34874579427871594 0.48316069857146854 20.5648189324222 -9.871107114826717 6.707575611404739 1.0000000156427424 0.4159532464275297 0.9617930365913746 0.05487465489044712 1.2833103515095083e-08 2.2426711816011292e-09 0.053132157713323976 0.01771071870995517 1.345528450640184e-10 9.871107114826717 -0.5840467692152127 KGFPHVIYAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGFPHVIYAR 10 1 K7EIU8;Q13485;K7EL15;K7EL18;K7EIJ2;K7ES96 K7EIU8 SMAD4 Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 4 0 4390610.0 1338700.0 392610.0 2659300.0 False True 1296203.701267331 549381.2204341026 1962749.5527100633 1.0 0.42383864503469537 1.514229245596995 20.305861028067653 -6.7631347259974115 1.600603247270436 0.666641762803701 1.5188517437283369 0.7036607538977065 0.24245684055986294 0.2776814227429156 1.4027518205869802 0.11947724758791971 0.2862487614209102 1.725302588919196e-07 6.7631347259974115 0.8522099809246358 KGFPHVIYAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGFPHVIYAR 10 1 K7EIU8;Q13485;K7EL15;K7EL18;K7EIJ2;K7ES96 K7EIU8 SMAD4 Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 4 0 3729340.0 1183100.0 891640.0 1654600.0 False True 1620524.0420753246 852244.3965408183 1263817.5575566604 1.0 0.5259066662469205 0.7798820163989373 20.62802899394509 -10.053714595874476 5.15734901786073 1.0000045723302833 0.6528943413218886 0.7135045356180598 0.10368500252314987 5.451184996958558e-06 1.0001701074951495e-06 0.10039389414458341 0.0334641906681146 8.836604223682037e-11 10.053714595874476 -0.34711023100839467 KGFPHVIYAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGFPHVIYAR 10 1 K7EIU8;Q13485;K7EL15;K7EL18;K7EIJ2;K7ES96 K7EIU8 SMAD4 Mothers against decapentaplegic homolog;Mothers against decapentaplegic homolog 4 0 8027300.0 1343700.0 1947000.0 4736600.0 False True 1739446.1382868325 1838647.7384494487 3874587.401620178 1.0 1.0570305673622749 2.227483401950135 20.730196576117823 -6.917043771535758 0.8463735770936633 0.9713220987517336 2.403959707400108 0.9933193366211173 0.0462359024289726 0.09994237522215672 0.11486189295721581 0.03922550606330806 0.11437245188282417 1.2104761263147662e-07 6.917043771535758 1.432637608648374 up KGFSCVK(ub)NELLPSHPLELSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGFSCVKNELLPSHPLELSEK 21 2 Q9Y244 Q9Y244 POMP Proteasome maturation protein 1 18132000.0 4751500.0 7762700.0 5617800.0 True False 6229262.513591447 6604535.4187675975 5036523.945742761 1.0 1.0602435528053848 0.8085265205557987 22.570629941086487 -6.843547045227673 1.265922659195502 1.0320475237593931 0.7996542654448648 0.9303648875569206 0.028319363457616074 0.16469897821641255 0.5111817573513721 0.017530813618628287 0.040431991613180285 1.4336824030799933e-07 6.843547045227673 -0.23239325831452828 KGFSCVK(ub)NELLPSHPLELSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGFSCVKNELLPSHPLELSEK 21 2 Q9Y244 Q9Y244 POMP Proteasome maturation protein 1 40293000.0 17226000.0 10638000.0 12429000.0 True False 16679170.05903567 14885808.87643714 9173472.037992459 1.0 0.8924789916853804 0.5499957135470825 23.99154416753233 -6.950096177051993 0.5577863487711914 1.00453219704881 0.42163674547700514 0.9992088115088225 0.0053971953669836896 0.0834471323047994 0.03580265233875238 0.005801076326196995 0.028456144277476527 1.1217700042670779e-07 6.950096177051993 -0.5828954515718048 KGFSCVK(ub)NELLPSHPLELSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGFSCVKNELLPSHPLELSEK 21 2 Q9Y244 Q9Y244 POMP Proteasome maturation protein 1 106989000.0 41117000.0 38279000.0 27593000.0 True False 62377495.055345066 31447813.374807905 22139231.455558494 1.0 0.5041531941432645 0.35492338119565775 25.89452228258899 -13.999999999999998 0.16825524241593387 3.4893544493993773 0.2208104377320894 0.9995171164115008 0.006059119722789422 12.075039143991535 0.12985778401430093 9.80940580569484 0.1236255550660505 1.0000000000000041e-14 13.999999999999998 -3.268544011667288 KGFSCVK(ub)NELLPSHPLELSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGFSCVKNELLPSHPLELSEK 21 2 Q9Y244 Q9Y244 POMP Proteasome maturation protein 1 20892900.0 4751500.0 7384300.0 8757100.0 True False 6508257.954459382 7058037.209385358 6688853.338135764 1.0 1.0844741033273386 1.0277486517805643 22.63384000260938 -10.201142749757206 5.260907537065751 0.9999964816993477 1.0561113775539686 0.566089334939192 0.023158068619821594 9.557393412123004e-07 1.4507680100818426e-07 0.02242410923606092 0.007474234507899454 6.292993022919992e-11 10.201142749757206 0.056114895854620817 KGFSCVK(ub)NELLPSHPLELSEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGFSCVKNELLPSHPLELSEK 21 2 Q9Y244 Q9Y244 POMP Proteasome maturation protein 1 107173000.0 41117000.0 49998000.0 16058000.0 True False 53226767.03724026 47215567.34822571 13135608.768993959 1.0 0.8870643470641605 0.24678577152363196 25.66564860468144 -6.937046602219707 0.6864943136192332 1.0076850920218154 0.08816136339138518 0.9977508300262242 0.015729569523847055 0.08914037824061116 0.06094244909840682 0.014988340666486188 0.05586228686513879 1.1559881915573525e-07 6.937046602219707 -0.9195237286304303 down KGIAFPTSISVNNCVCHFSPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGIAFPTSISVNNCVCHFSPLK 22 1 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 162567000.0 49968000.0 70420000.0 42179000.0 False True 65508531.890800305 59913610.49501 37814721.68953755 1.0 0.9145924777383688 0.5772488040576599 25.965179481013532 -6.945164751861187 0.6096225914423039 1.00373343377463 0.47055140314593974 0.9987651138996332 0.006413835401160588 0.08548740210695137 0.044459430446173474 0.006521847674417184 0.028441921417205408 1.1345803251000513e-07 6.945164751861187 -0.5331820306286903 KGIAFPTSISVNNCVCHFSPLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGIAFPTSISVNNCVCHFSPLK 22 1 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 127230000.0 91460000.0 29233000.0 6537000.0 False True 88556652.36267288 40905889.34808112 4824763.594203618 1.0 0.46191774707738587 0.054482226523699114 26.400097350298317 -8.135134244078245 0.46597990833827846 1.0438897706117116 4.6880160178739764e-21 0.995072444285145 0.02718237502278969 0.10500066382030596 0.12426936013994146 0.052062010874627716 0.07808293674145714 7.325980459165295e-09 8.135134244078245 -1.0438897706117116 KGIAFPTSISVNNCVCHFSPLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGIAFPTSISVNNCVCHFSPLK 22 1 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 621074000.0 138912000.0 175772000.0 306390000.0 False True 210739659.8275187 144404113.28709555 245831882.20449257 1.0 0.6852251417947817 1.166519308257854 27.650886604588763 -6.73025132453208 1.7223637545696806 0.8106209030015554 1.1662428560216924 0.5603907669795244 0.1323213899478976 0.33577629749437893 1.9515638518235852 0.060878875753301 0.15102093998480426 1.8610098657960827e-07 6.73025132453208 0.355621953020137 KGIAFPTSISVNNCVCHFSPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGIAFPTSISVNNCVCHFSPLK 22 1 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 357490000.0 49968000.0 121245000.0 186277000.0 False True 68442519.93442632 115887994.99640149 142282209.09523883 1.0 1.6932163676532062 2.0788569624782536 26.028389542536424 -9.484621229795298 0.150185794193781 6.009956064098697e-20 2.6925535257564586 0.9997833041565268 0.00657079967172212 0.9396685864081861 0.05963917923440958 0.7189581444450674 0.3184620657952893 3.27626309802638e-10 9.484621229795298 2.6925535257564586 KGIAFPTSISVNNCVCHFSPLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGIAFPTSISVNNCVCHFSPLK 22 1 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 174840000.0 91460000.0 7648000.0 75732000.0 False True 76053042.36499338 7606798.705990864 91567211.05479507 1.0 0.10001965035776418 1.2039914276584252 26.180502625732593 -6.689948399243956 1.8666405700308089 0.43574352092120333 1.2001700891378186 0.37018485622429775 0.38063188710036944 0.41676883272860304 2.815469925278712 0.16313176251240694 0.4248275902065802 2.0419805484444412e-07 6.689948399243956 0.7644265682166154 KGIAFPTSISVNNCVCHFSPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGIAFPTSISVNNCVCHFSPLK 22 1 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 519642000.0 138912000.0 146420000.0 234310000.0 False True 179824322.3648883 138271598.2864756 191667984.22362518 1.0 0.7689260077171512 1.0658624022767313 27.422012926681212 -6.699016266486115 1.8340813724880884 0.8563715572677348 1.064969654588394 0.41292118212468687 0.09755756435519025 0.3976395808203768 2.59973007802626 0.04244310249048798 0.10929722704445585 1.999786966272284e-07 6.699016266486115 0.20859809732065915 KGILLQLFGGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGILLQLFGGTR 12 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 16568900.0 6870200.0 5063900.0 4634800.0 False True 6652109.261557346 7085941.677889642 3420806.8389804093 1.0 1.0652172715862351 0.514243934438857 22.665380434553743 -6.877364567109826 1.0943338598532046 1.039174553858298 0.4771089586587101 0.9714993450843334 0.04149725027280693 0.1299929623759557 0.2865782785820709 0.0292754720369117 0.07034849418516126 1.3262806482671377e-07 6.877364567109826 -0.5620655951995879 KGILLQLFGGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGILLQLFGGTR 12 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 32065500.0 1550500.0 20354000.0 10161000.0 False True 2123761.7506869994 19454692.978322897 7761181.072363854 1.0 9.16048750385002 3.654449972956359 21.018190499128472 -9.629317367294853 10.922056417221313 0.9999629782289017 6.407468738046844 0.5625589122959282 2.247830409318831 0.0 0.0 2.1764524350516896 0.7254841450172297 2.3479164181651043e-10 9.629317367294853 5.407505759817942 KGILLQLFGGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGILLQLFGGTR 12 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 11572300.0 6870200.0 2207500.0 2494600.0 False True 5712875.701464872 2195607.759345558 3016209.3262728006 1.0 0.3843261912354525 0.5279669091171364 22.44578570998802 -10.12650460602852 7.824951664864312 1.0000000795101571 0.4561465501770569 0.9502829269670174 0.05864107751619949 8.137803747417237e-08 9.08250080223106e-09 0.05677898761658456 0.01892632638532491 7.473007084478627e-11 10.12650460602852 -0.5438535293331002 KGLDVK(ub)SEACQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGLDVKSEACQR 12 2 Q93008;Q93008-3 Q93008 USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X 1 24037900.0 6189800.0 13231000.0 4617100.0 True False 9390379.134994648 10869824.675725155 3704528.161253185 1.0 1.1575490743730603 0.39450251241163503 23.1627519769513 -6.852860362901334 1.2211055344429385 1.0843324668681935 0.36225657284397983 0.9443739260437818 0.077576123615302 0.15434291378558965 0.44141567523647907 0.04967052843249997 0.11517803997701244 1.403264818583151e-07 6.852860362901334 -0.7220758940242137 down KGLDVK(ub)SEACQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGLDVKSEACQR 12 2 Q93008;Q93008-3 Q93008 USP9X Probable ubiquitin carboxyl-terminal hydrolase FAF-X 1 4636800.0 1585900.0 1341100.0 1709800.0 True False 2172250.0873360294 1281845.7675753576 1305980.4544363464 1.0 0.5901004562266438 0.6012109112344217 21.050758776973613 -9.991793889256929 5.08355071682816 1.000002344215957 0.5956556837282092 0.9994340512315124 0.004535824292864237 6246999.479389992 1.9570763725107394 221.58292699393846 0.0015527332966562336 1.0190749135479601e-10 9.991793889256929 -0.4043466604877477 KGLEQGNLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGLEQGNLKK 10 2 Q9Y5T5-2;Q9Y5T5;Q9Y5T5-3;Q9Y5T5-5;H9KVB6 Q9Y5T5-2 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 6128800.0 1474500.0 3133300.0 1521000.0 True False 1427692.8046004954 4384443.029943645 1122604.470978078 1.0 3.0709988982332397 0.7863067372481514 20.44525415866573 -6.668001702694531 1.9443468989856314 2.3241327260219315 0.795583822302185 0.2703557278453129 0.8801136567417286 0.46566849725933285 3.39200950863838 0.36465268397664363 0.9768453481428067 2.147822053364934e-07 6.668001702694531 -1.5285489037197464 KGLIAAICAGPTALLAHEIGFGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGLIAAICAGPTALLAHEIGFGSK 24 1 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 102896200.0 49156000.0 18593200.0 35147000.0 False True 47595569.686634 26017561.72225706 25940946.3126013 1.0 0.5466383088500657 0.5450285915978048 25.5043239543711 KGLIAAICAGPTALLAHEIGFGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGLIAAICAGPTALLAHEIGFGSK 24 1 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 940812400.0 243848400.0 240520000.0 456444000.0 False True 369935850.5059662 197597326.80866244 366227643.3334878 1.0 0.5341394367115432 0.9899760805355668 28.462699878000738 -10.857682739522728 10.470744871680381 1.0076966869543686 0.7620577586235551 0.2664848177358715 0.1860945305719425 0.03337034780283218 0.0004535653385433218 0.17983029138028753 0.06006175147711838 1.3877692508108224e-11 10.857682739522728 -0.24563892833081358 KGLIAAICAGPTALLAHEIGFGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGLIAAICAGPTALLAHEIGFGSK 24 1 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 38437200.0 28205300.0 4825600.0 5406300.0 False True 38633561.629572436 4612389.035874765 4129443.286243553 1.0 0.11938813925828073 0.10688746033403843 25.20335135002529 KGLIAAICAGPTALLAHEIGFGSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGLIAAICAGPTALLAHEIGFGSK 24 1 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 113151980.0 49156000.0 22131200.0 41864780.0 False True 40875391.980030745 22011974.83290072 50618511.93712781 1.0 0.5385140977646024 1.2383615051779069 25.284729229805375 -6.72886394460413 1.7274127299303268 0.7219301525380638 1.2378569131200357 0.5539888139565448 0.19401533058882375 0.3383641549015708 1.9775072337063095 0.08902571817575886 0.22119258879091633 1.8669644802300293e-07 6.72886394460413 0.5159267605819718 KGLIAAICAGPTALLAHEIGFGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGLIAAICAGPTALLAHEIGFGSK 24 1 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 0 642217400.0 243848400.0 219508000.0 178861000.0 False True 315666560.77057624 207292186.83696014 146310133.2688398 1.0 0.656680854414663 0.4634958258222884 28.233826200093187 -10.541609008948859 0.10692929873508132 1.8928565952729237 1.1174800856511315e-20 0.9998889354093787 0.0023381881569870737 2.44981059555795 0.05784497175723841 0.8402027485724989 0.2782923881911581 2.873366281316181e-11 10.541609008948859 -1.8928565952729237 KGLLPQILENLLSAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGLLPQILENLLSAR 15 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 762850000.0 305570000.0 185580000.0 271700000.0 False True 463572030.15934485 152461799.05684194 217998375.9096598 1.0 0.3288848099926043 0.470257827752737 28.788218282372295 -9.974804840515421 7.136842150194047 1.000000028960452 0.3995713188767376 0.9600810275366044 0.057715292818293504 2.6630723607454208e-08 3.733709973832291e-09 0.05588259447481657 0.018627530658894314 1.0597298303879321e-10 9.974804840515421 -0.6004287100837145 KGLLPQILENLLSAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGLLPQILENLLSAR 15 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 602410000.0 305570000.0 174610000.0 122230000.0 False True 395566388.68520314 164892800.00547412 99985394.18570988 1.0 0.4168524038494533 0.2527651414419832 28.559344604464744 -13.999999999999998 0.1778763039884179 4.006358973159542 0.11952394492893104 0.9995008534533042 0.007163819605271978 12.17798188051545 0.13367755642630713 12.647557740323386 0.12476084665278812 1.0000000000000041e-14 13.999999999999998 -3.8868350282306108 KGLTPSQIGVILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGLTPSQIGVILR 13 1 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 0 113538200.0 44903000.0 17573200.0 51062000.0 False True 58868267.84127053 14951347.059797093 45778594.061290376 1.0 0.2539797348906403 0.777644658829193 25.8109868421667 -9.97175997306654 6.445132353176168 1.0000001142538366 0.5158121968626647 0.5326842608635565 0.21378530997384168 3.510814357103729e-07 5.599352875439117e-08 0.2069967856493663 0.06899891209936757 1.0671857731059721e-10 9.97175997306654 -0.48418791739117195 KGLTPSQIGVILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGLTPSQIGVILR 13 1 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 0 56862000.0 20043100.0 7034200.0 29784700.0 False True 19406842.761538275 9842992.742868409 21983193.548153054 1.0 0.5071918633965481 1.1327547617235687 24.210062093815644 -6.696667905231595 1.8428537730378955 0.6929927640364154 1.130776757879379 0.40176589357390713 0.20814966404207794 0.4024771712785927 2.654994559215463 0.09019204085535007 0.23290019683122004 2.010629706133158e-07 6.696667905231595 0.4377839938429636 KGLTPSQIGVILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGLTPSQIGVILR 13 1 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 0 97879000.0 14863000.0 17450000.0 65566000.0 False True 22548257.630848385 14335911.16252772 52606851.361401334 1.0 0.6357879795960237 2.3330783345951147 24.426512620776332 -6.850578202669702 1.2323868303205152 0.8055533058155897 2.4016548829811013 0.9411299367106717 0.1770183785256633 0.15682356576713502 0.45806181218005376 0.1123834215470008 0.26014556975183284 1.4106581987608833e-07 6.850578202669702 1.5961015771655116 up KGLTPSQIGVILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGLTPSQIGVILR 13 1 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 0 93384000.0 44903000.0 26042700.0 22438300.0 False True 61504852.557947986 24892047.402307607 17138835.67129436 1.0 0.4047168047245554 0.27865826773825164 25.87419690368959 -13.999999999999998 0.21817301550036164 4.563692381182858 0.21003742173296272 0.9994961294612253 0.007061162295284436 12.950564862698686 0.14798558760668118 19.864756058814695 0.07061419106270253 1.0000000000000041e-14 13.999999999999998 -4.353654959449895 KGLTPSQIGVILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGLTPSQIGVILR 13 1 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 0 37431700.0 20043100.0 8631500.0 8757100.0 False True 16666725.709881919 8585000.396281386 10588169.121744385 1.0 0.5150981989936528 0.635287896738261 23.99046736924992 -10.053067793077538 7.389185384439214 1.0000000427694806 0.5751930478659832 0.9433640922372378 0.049067238635604846 3.457644506598351e-08 4.407159103231563e-09 0.04750915447558584 0.015836383173340213 8.849774546606369e-11 10.053067793077538 -0.4248069949034974 KGLTPSQIGVILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGLTPSQIGVILR 13 1 P62277;J3KMX5 P62277 RPS13 40S ribosomal protein S13 0 151652000.0 14863000.0 110803000.0 25986000.0 False True 19240446.49353069 104636715.64633505 21256814.638876397 1.0 5.438372528491871 1.104798407148383 24.19763894286878 -6.640645132594416 2.0423202775170863 3.9010802558098785 1.1229167919711027 0.15698978018501808 1.8987557837273497 0.5317632701879021 4.239994276520015 0.7569304139692735 2.1023105809351827 2.2874671577185184e-07 6.640645132594416 -2.7781634638387755 KGPELPLVPVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGPELPLVPVKR 12 2 Q96DI7;Q96DI7-2 Q96DI7 SNRNP40 U5 small nuclear ribonucleoprotein 40 kDa protein 1 10020000.0 2518800.0 4653200.0 2848000.0 True False 2438842.0727214143 6511247.026117438 2102023.361831407 1.0 2.6698108495609874 0.8618940050865354 21.21776490872994 -6.663946771976805 1.9586005374387978 2.0712970913578674 0.8693155206392995 0.252672256213041 0.7102966725391411 0.4751285625627137 3.5077011299075265 0.29255831116856934 0.7879307259455687 2.1679697993662112e-07 6.663946771976805 -1.201981570718568 KGPELPLVPVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGPELPLVPVKR 12 2 Q96DI7;Q96DI7-2 Q96DI7 SNRNP40 U5 small nuclear ribonucleoprotein 40 kDa protein 1 8461400.0 2518800.0 4732900.0 1209700.0 True False 2094493.8017597354 4707402.928292899 1462642.6769791571 1.0 2.247513420349046 0.6983275270379341 20.998170184164216 -6.692373481294767 1.8580218967056101 1.780360775149661 0.7035267609468435 0.38156985372289265 0.5273577323135172 0.41157008933107025 2.7565803813962573 0.22690619010466612 0.5891091878424173 2.0306099911762952e-07 6.692373481294767 -1.0768340142028174 KGPGLAVQSGDK(ub)TK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGPGLAVQSGDKTK 14 2 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 9422500.0 2633400.0 3831400.0 2957700.0 True False 3452412.9018818736 3259770.0546802245 2651665.576261771 1.0 0.9442005192667883 0.768061541774559 21.719173587686395 -6.950301531369672 0.5555281931244315 1.0023598775763751 0.7015486506150976 0.9992246986322671 0.002752272340457993 0.08336497856499689 0.03546370923565547 0.0029664730178543654 0.014628098562824658 1.1212397054271273e-07 6.950301531369672 -0.3008112269612775 KGPGLAVQSGDK(ub)TK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGPGLAVQSGDKTK 14 2 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 11988300.0 3996100.0 3583700.0 4408500.0 True False 3869245.9928545463 5014690.098748612 3253781.597834884 1.0 1.2960380673674903 0.840934281212345 21.883621022424173 -6.7311504069159085 1.719040261437978 1.1779263475330481 0.8411481956000955 0.5645814546112734 0.1244365140932038 0.3340898098363035 1.9346710649231251 0.057351814105001855 0.1421293974893758 1.8571611628798428e-07 6.7311504069159085 -0.3367781519329527 KGPGLAVQSGDK(ub)TK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGPGLAVQSGDKTK 14 2 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 29532100.0 4182800.0 4780300.0 20569000.0 True False 6345613.403640763 3927218.116345624 16503528.134287022 1.0 0.6188870746667932 2.600777432299643 22.597328199366412 -6.8568714602649585 1.2014221077029084 0.7947060637436176 2.691182063734968 0.9497274970232504 0.1925240155874007 0.15005699289906063 0.41336154367644123 0.125133367576333 0.29114944757185857 1.3903640814917537e-07 6.8568714602649585 1.8964759999913503 up KGPGLAVQSGDK(ub)TK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGPGLAVQSGDKTK 14 2 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 10414100.0 2633400.0 3958200.0 3822500.0 True False 3607039.144959138 3783313.63598298 2919704.226858662 1.0 1.0488695808223172 0.8094462270915382 21.782383649209287 -6.853533277770084 1.2178841124892337 1.0261804097707647 0.799200461592647 0.945294595848448 0.02415908019928958 0.15361348084011675 0.4366740433098864 0.015506900797129604 0.035975310623373495 1.40109222227906e-07 6.853533277770084 -0.22697994817811773 KGPGLAVQSGDK(ub)TK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGPGLAVQSGDKTK 14 2 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 10877600.0 3996100.0 4931200.0 1950300.0 True False 3322934.2072463348 4904634.646833435 2358098.7128316523 1.0 1.4759951118315493 0.7096435155680596 21.66402629785845 -6.7387398117878545 1.6914485414365494 1.2836333709917405 0.7093303545324093 0.5991876118490482 0.19999968510525848 0.320113705146719 1.7978027381164874 0.09356215166892427 0.2298992098321143 1.8249887356523246e-07 6.7387398117878545 -0.5743030164593311 KGPGLAVQSGDK(ub)TK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGPGLAVQSGDKTK 14 2 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 1 26095700.0 4182800.0 3561900.0 18351000.0 True False 5414717.055314554 3363677.1338382554 15011306.29716079 1.0 0.6212101388634519 2.7723159204463266 22.36845452145886 -6.861436682365381 1.1785537494579126 0.7936720905945256 2.8793290135060037 0.9553574945485271 0.19810334841525787 0.1453232031583547 0.38275967689398016 0.13103070401151276 0.30635593938391664 1.375825383072067e-07 6.861436682365381 2.085656922911478 up KGPK(ub)HLDDDEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGPKHLDDDEDR 12 2 O15234;J3KSY7 O15234 CASC3 Protein CASC3 1 2584750.0 501710.0 1563700.0 519340.0 True False 657746.668566551 1330402.055254859 465603.6786610503 1.0 2.0226663529201114 0.7078769090168952 19.327172510713286 -6.699113754163059 1.8340118730583117 1.6355870257536405 0.7118510008557887 0.4133688519926598 0.43175085801581764 0.3973753361558275 2.5979405514543195 0.1878513980984033 0.48363669081790145 1.999338117128678e-07 6.699113754163059 -0.9237360248978518 KGPSGYGFNLHSDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGPSGYGFNLHSDK 14 1 O14745;O14745-2 O14745 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 0 40829000.0 12009000.0 10097000.0 18723000.0 False True 15743915.295321435 8590566.957797743 16785723.56369783 1.0 0.5456436214662926 1.0661721210279875 23.908291028101655 -6.676057334660009 1.916271120336844 0.711507841950114 1.0641176212585803 0.30604860704868586 0.19273581321643246 0.44731857909112294 3.172367774600964 0.08081518010787572 0.21419789572980003 2.1083497915770747e-07 6.676057334660009 0.3526097793084664 KGPSGYGFNLHSDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGPSGYGFNLHSDK 14 1 O14745;O14745-2 O14745 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 0 33065100.0 7773100.0 4668000.0 20624000.0 False True 7526347.195279828 6531956.743298418 15221955.693262266 1.0 0.8678787430102819 2.0224891701526553 22.843518412723444 -6.878428557205881 1.0884840496515578 0.9196897583465229 2.1019027449017558 0.9723974697022659 0.08572401882167123 0.1290331564830959 0.28075166956461217 0.06074859803891367 0.1463418564204541 1.323035333540038e-07 6.878428557205881 1.1822129865552329 up KGPSGYGFNLHSDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGPSGYGFNLHSDK 14 1 O14745;O14745-2 O14745 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 0 31948000.0 8458900.0 16415000.0 7074100.0 False True 12832769.72842519 13485614.999019634 5675901.03431183 1.0 1.050873294262295 0.44229742716721876 23.61332924868535 -6.88660569520771 1.0422876265782162 1.0354097401257834 0.3933134155699434 0.9786339903148672 0.04029616245285201 0.12193891902097172 0.23829892060097574 0.029581983731064715 0.07290009189634793 1.2983575412314073e-07 6.88660569520771 -0.64209632455584 down KGPSGYGFNLHSDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGPSGYGFNLHSDK 14 1 O14745;O14745-2 O14745 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 0 34936500.0 12009000.0 7051500.0 15876000.0 False True 16449051.83102238 6739941.413807788 12126415.776483476 1.0 0.40974649986186296 0.737210624725095 23.971501089624546 -10.17874881293674 5.572255175890697 1.0000113166969646 0.5734785622934739 0.6934398073013318 0.13368666916378547 1.8795374356438334e-05 2.770029825888734e-06 0.1294449933347332 0.0431471869400885 6.625996269946173e-11 10.17874881293674 -0.4265327544034907 KGPSGYGFNLHSDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGPSGYGFNLHSDK 14 1 O14745;O14745-2 O14745 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 0 22031600.0 7773100.0 8965700.0 5292800.0 False True 6463677.05671693 8917399.994547894 6399500.008857804 1.0 1.3796171925515837 0.9900711240218237 22.62392368815772 -6.652007692548665 2.0008641371376266 1.2459305979031328 0.991690569342893 0.202480817056924 0.16194269917407733 0.5035958210352692 3.8665515797061523 0.065580515623751 0.17944908254107858 2.2283956779099057e-07 6.652007692548665 -0.25424002856023975 KGPSGYGFNLHSDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGPSGYGFNLHSDK 14 1 O14745;O14745-2 O14745 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 0 23739000.0 8458900.0 9504800.0 5775300.0 False True 10950212.799847065 8975849.524609305 4724254.659582186 1.0 0.8196963555570962 0.4314303973753064 23.3844555707778 -6.958574655368357 0.4550849421833071 1.0118901163009772 0.22371345181251154 0.9997136016751861 0.004014825331534073 0.08021439272463265 0.023043505872378012 0.005230489049192466 0.03209336367843069 1.1000827244487505e-07 6.958574655368357 -0.7881766644884657 down KGPSTVTDLEDTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGPSTVTDLEDTKR 14 2 O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O94973 AP2A2 AP-2 complex subunit alpha-2 1 17005100.0 6081900.0 4378600.0 6544600.0 True False 5888833.41356374 6126997.814097353 4830372.926208501 1.0 1.040443392401804 0.8202597334614204 22.489550431705794 -6.859300506004978 1.1892529366614908 1.0219039075472545 0.8097384924395771 0.9527829435498812 0.020794696713014624 0.14752789224252852 0.39687488318905134 0.013641520370647607 0.03181898545099866 1.382609364292633e-07 6.859300506004978 -0.2121654151076774 KGPSTVTDLEDTK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGPSTVTDLEDTKR 14 2 O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O94973 AP2A2 AP-2 complex subunit alpha-2 1 8021400.0 0.0 4921200.0 3100200.0 True False 0.0 4703765.111767835 2367996.610623208 0.0 KGPSTVTDLEDTK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGPSTVTDLEDTKR 14 2 O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O94973 AP2A2 AP-2 complex subunit alpha-2 1 18009200.0 6081900.0 9473100.0 2454200.0 True False 5057369.323853628 9422066.530036863 2967361.873061294 1.0 1.8630370705964996 0.5867401969370541 22.26995570714007 -6.724573047991483 1.7429441031172765 1.5224791451404847 0.5882087990066832 0.533988345293734 0.3629799693703625 0.34649637790209625 2.0594864841236205 0.16520908859435868 0.4125094946390456 1.8855018028920587e-07 6.724573047991483 -0.9342703461338014 KGQDSIEPVPGQKGK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGQDSIEPVPGQKGK 15 2 Q9NR50;Q9NR50-3;Q9NR50-2 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 2774160.0 596330.0 968230.0 1209600.0 True False 781794.4048679343 823773.8581309805 1084442.1953025123 1.0 1.0536962825541552 1.3871194121499286 19.57642973404717 -6.935112576133623 0.7035564590705906 0.995761202834733 1.465427123555737 0.9974511952542826 0.008645289812498581 0.09006847784143616 0.06530189032547912 0.008131386523383457 0.02936737139831415 1.161147586646067e-07 6.935112576133623 0.469665920721004 KGQSPLDLCPDPNLCK(ub)ALAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGQSPLDLCPDPNLCKALAK 20 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 31845500.0 5377200.0 9167300.0 17301000.0 True False 7049561.27287888 7799574.573855517 15510858.482910663 1.0 1.1063914862137725 2.200258694478498 22.74910204397926 -6.925745262532453 0.7809142599620493 0.9804849632269773 2.4022942246654617 0.9956342800646835 0.03584309304475591 0.09490733636485507 0.0889457111096235 0.03186346654012141 0.10138932260291515 1.1864644704136864e-07 6.925745262532453 1.4218092614384843 up KGQSPLDLCPDPNLCK(ub)ALAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGQSPLDLCPDPNLCKALAK 20 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 121794000.0 25232000.0 53953000.0 42609000.0 True False 38278788.706288576 44324665.613286935 34187312.4738119 1.0 1.157943266005309 0.8931137486123089 25.190041842126394 -6.745152584643714 1.6676709594557129 1.0934104918687646 0.8927725824678983 0.6278888146690359 0.06635917221167831 0.308583113165909 1.6869029335881685 0.03145401524665742 0.07675793964050653 1.798239012406191e-07 6.745152584643714 -0.20063790940086634 KGQSPLDLCPDPNLCK(ub)ALAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGQSPLDLCPDPNLCKALAK 20 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 43558200.0 5377200.0 13460000.0 24721000.0 True False 7365296.153366108 12865292.693732226 18882408.94497658 1.0 1.7467447914979621 2.5636998909197817 22.81231210550215 -6.969972354852422 0.2588458553127872 0.7673830264604384 3.5672630474609575 0.9999821662401767 0.0026967712997201204 0.0763116899525594 0.009062251307811702 0.01718211126979838 0.07721517448294198 1.0715875152964225e-07 6.969972354852422 2.799880021000519 KGQSPLDLCPDPNLCK(ub)ALAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGQSPLDLCPDPNLCKALAK 20 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 98669000.0 25232000.0 51805000.0 21632000.0 True False 32663321.397077776 48922006.20974503 17695197.96306371 1.0 1.497765815515682 0.5417452116381162 24.961168164218844 -6.7652170722948135 1.5929059243128902 1.2872431268767082 0.537326722977041 0.7119055003269474 0.20954760828248248 0.2742200626664752 1.3724008193234971 0.10374247595855396 0.24803511666612366 1.717049943977816e-07 6.7652170722948135 -0.7499164038996672 KGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSR 37 1 P06576;H0YH81;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 336198000.0 43906000.0 211928000.0 80364000.0 False True 66608611.9585569 174107792.5989784 64480020.17520757 1.0 2.613893121017238 0.9680432946917779 25.98920538244919 -6.650626529324035 2.0060212660647005 2.0467142401920038 0.9749179407090226 0.19673026288980378 0.6887163670469643 0.506976389343283 3.911105655450953 0.2783517044665735 0.762997326880191 2.2354938049332423e-07 6.650626529324035 -1.071796299482981 KGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSR 37 1 P06576;H0YH81;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 145564000.0 43906000.0 55809000.0 45849000.0 False True 56837182.51664941 52703180.089946255 37504952.45046734 1.0 0.9272658804737167 0.659866495660318 25.76033170454164 -6.9468152996079064 0.5927842125156592 1.00306617937729 0.5705466917237976 0.9989270092629559 0.00479041514784122 0.0847904926780648 0.04145436309616681 0.004952256983841632 0.022420290850491388 1.1302765059229131e-07 6.9468152996079064 -0.43251948765349235 KGSPVSEIGWETPPPESPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGSPVSEIGWETPPPESPR 19 1 A0A3B3ITC2;Q13884-2;Q13884 A0A3B3ITC2 SNTB1 Beta-1-syntrophin 0 33710700.0 13536000.0 13198000.0 6976700.0 False True 17745827.082810465 11228909.845401073 6254818.009232002 1.0 0.6327633980091005 0.3524669760414123 24.08097648011291 -7.782677371867168 0.21179040004433222 1.2078125233920782 1.3849452957547036e-10 0.9998653693184718 0.0030765109763748813 0.12606053641665294 0.029781816425416444 0.053609430984109356 0.08780114499067482 1.6493872312058493e-08 7.782677371867168 -1.2078125232535837 down KGSPVSEIGWETPPPESPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGSPVSEIGWETPPPESPR 19 1 A0A3B3ITC2;Q13884-2;Q13884 A0A3B3ITC2 SNTB1 Beta-1-syntrophin 0 38248000.0 12639000.0 15307000.0 10302000.0 False True 12237781.863238811 21419164.924950473 7603597.146624701 1.0 1.7502489555964145 0.6213215132936156 23.5448387528874 -6.727540670823384 1.7321688000241944 1.4527254955908013 0.6222847759030455 0.5478523496966105 0.315452159034303 0.340861722307602 2.0024497670002783 0.14438546943805447 0.3592885279040831 1.8726617037232263e-07 6.727540670823384 -0.8304407196877558 KGSPVSEIGWETPPPESPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGSPVSEIGWETPPPESPR 19 1 A0A3B3ITC2;Q13884-2;Q13884 A0A3B3ITC2 SNTB1 Beta-1-syntrophin 0 71962000.0 31604000.0 22026000.0 18332000.0 False True 47945578.5618874 18095288.210076537 14708672.16479896 1.0 0.3774130744239414 0.3067784894036316 25.51489444335591 -13.999999999999998 0.30720663365143336 6.920818995795205 0.2906630563416875 0.9996658395382446 0.005693809287236912 17.073315090499666 0.17625572495900568 64.51762293820534 0.024761140836902687 1.0000000000000041e-14 13.999999999999998 -6.630155939453518 KGSPVSEIGWETPPPESPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGSPVSEIGWETPPPESPR 19 1 A0A3B3ITC2;Q13884-2;Q13884 A0A3B3ITC2 SNTB1 Beta-1-syntrophin 0 32015100.0 13536000.0 10934000.0 7545100.0 False True 18540624.996645752 10450899.726097208 5763102.776212234 1.0 0.5636756974475194 0.3108364889131222 24.1441865416358 -8.954636133923524 0.18329735674171177 1.4211881803066997 5.114806617377845e-09 0.9996987859672245 0.004940320606293744 0.4332034039340403 0.058520093617109935 0.25279380384806893 0.14705904308210968 1.1101045074945015e-09 8.954636133923524 -1.421188175191893 down KGSPVSEIGWETPPPESPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGSPVSEIGWETPPPESPR 19 1 A0A3B3ITC2;Q13884-2;Q13884 A0A3B3ITC2 SNTB1 Beta-1-syntrophin 0 40927800.0 12639000.0 19961000.0 8327800.0 False True 10509888.502636679 19853466.131051697 10069104.476603324 1.0 1.8890272837881144 0.9580600663914967 23.325244028321677 -6.656629982529282 1.9850223735453272 1.5738366900596839 0.9619710030978927 0.2213539450893981 0.3788345009686814 0.4924527718915921 3.7265781282671795 0.1543874498533864 0.4197731280988922 2.2048041489347626e-07 6.656629982529282 -0.6118656869617911 KGSPVSEIGWETPPPESPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGSPVSEIGWETPPPESPR 19 1 A0A3B3ITC2;Q13884-2;Q13884 A0A3B3ITC2 SNTB1 Beta-1-syntrophin 0 63653000.0 31604000.0 17510000.0 14539000.0 False True 40912001.00797578 16535553.107472945 11893051.18273776 1.0 0.40417365809727435 0.2906983498660751 25.28602076544836 -13.999999999999998 0.23318665525877905 4.817596305213344 0.23717232145485598 0.999514307588894 0.0068559392087406065 13.392641827618274 0.15287686682331292 23.71476360186144 0.057758264267681436 1.0000000000000041e-14 13.999999999999998 -4.580423983758489 KGSPYHTGQLHPAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGSPYHTGQLHPAVR 15 1 Q92729-3;Q92729-2;Q92729-4;Q92729 Q92729-3 PTPRU Receptor-type tyrosine-protein phosphatase U 0 46429000.0 15126000.0 18417000.0 12886000.0 False True 19830332.480392385 15669255.388903731 11552680.331240198 1.0 0.7901660450926379 0.582576229756265 24.241205530572657 -6.9712581046310556 0.2261356265498973 1.0886147301436324 0.2782234416893864 0.9999905993177625 0.000522464533903303 0.07589659071432081 0.007553258005862681 0.005489194778502961 0.020775688158418276 1.0684197202468511e-07 6.9712581046310556 -0.810391288454246 KGSPYHTGQLHPAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGSPYHTGQLHPAVR 15 1 Q92729-3;Q92729-2;Q92729-4;Q92729 Q92729-3 PTPRU Receptor-type tyrosine-protein phosphatase U 0 45339000.0 14857000.0 13591000.0 16891000.0 False True 14385372.667310627 19017957.176128715 12466740.380861761 1.0 1.3220343758869166 0.8666261673700832 23.77809926021517 -6.7167410885466925 1.7709855872703326 1.196604691332452 0.8674617447990277 0.4970516598333582 0.13557095758998627 0.3617236613659573 2.215366750182462 0.060824208902234264 0.1532831519263543 1.9198129261007e-07 6.7167410885466925 -0.32914294653342424 KGSPYHTGQLHPAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGSPYHTGQLHPAVR 15 1 Q92729-3;Q92729-2;Q92729-4;Q92729 Q92729-3 PTPRU Receptor-type tyrosine-protein phosphatase U 0 152305000.0 35090000.0 73374000.0 43841000.0 False True 53234095.422624685 60279836.42632137 35175807.13380709 1.0 1.1323539161839917 0.660775896623149 25.665847224625413 -6.831798359282765 1.320081007858793 1.0706346479607638 0.6476340026062204 0.9093809903726089 0.059784434727839356 0.1786050122791453 0.6081009925922112 0.03555402046819677 0.08180845491403892 1.472996248350597e-07 6.831798359282765 -0.4230006453545434 KGSPYHTGQLHPAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGSPYHTGQLHPAVR 15 1 Q92729-3;Q92729-2;Q92729-4;Q92729 Q92729-3 PTPRU Receptor-type tyrosine-protein phosphatase U 0 69357000.0 15126000.0 15393000.0 38838000.0 False True 20718490.964780137 14712886.362156043 29665264.293717906 1.0 0.7101331070475564 1.4318255293856395 24.30441559209555 -6.797689660581812 1.4652591139491986 0.8395929152894245 1.4412360150398362 0.8253298033325553 0.12392776761299541 0.2240786994919237 0.950008610682802 0.06654319463475174 0.15498249073006842 1.5933468988201734e-07 6.797689660581812 0.6016430997504117 KGSPYHTGQLHPAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGSPYHTGQLHPAVR 15 1 Q92729-3;Q92729-2;Q92729-4;Q92729 Q92729-3 PTPRU Receptor-type tyrosine-protein phosphatase U 0 33482500.0 14857000.0 9879300.0 8746200.0 False True 12354253.776696978 9826078.250012489 10574989.982140297 1.0 0.7953599163186026 0.8559796628176126 23.558504535649448 -9.928421384754255 6.104147146993095 1.0000000501532529 0.8256697895680738 0.9168534675866906 0.024747907876694064 1.6884954302326524e-08 2.954002637244606e-09 0.02396206572763315 0.007987352921641613 1.179175956344241e-10 9.928421384754255 -0.1743302605851791 KGSPYHTGQLHPAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGSPYHTGQLHPAVR 15 1 Q92729-3;Q92729-2;Q92729-4;Q92729 Q92729-3 PTPRU Receptor-type tyrosine-protein phosphatase U 0 109388000.0 35090000.0 45818000.0 28480000.0 False True 45424696.72730894 43268188.022741094 23296932.229477387 1.0 0.9525256334122894 0.5128692959544069 25.436973546717862 -6.927480942451558 0.7671979627267865 1.0073479700149641 0.4281426652645334 0.9960193035997309 0.01383648764587197 0.09396752137178441 0.08424724549561434 0.012421628114318316 0.040346542077630276 1.1817321677371721e-07 6.927480942451558 -0.5792053047504307 KGTEVQVDDIK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGTEVQVDDIKR 12 2 Q9Y230;Q9Y230-2 Q9Y230 RUVBL2 RuvB-like 2 1 4241600.0 1094200.0 1761500.0 1385900.0 True False 1434506.7962478737 1498691.0662732227 1242500.3624915266 1.0 1.0447430923249934 0.8661516039808503 20.452123372488177 -6.840351450875009 1.2807891185944316 1.0238009674028998 0.8602375490407681 0.9250539506646678 0.020771571657286842 0.1683874671175695 0.5364248269725144 0.012716245374427577 0.029298127023638543 1.444270528215814e-07 6.840351450875009 -0.16356341836213173 KGTEVQVDDIK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGTEVQVDDIKR 12 2 Q9Y230;Q9Y230-2 Q9Y230 RUVBL2 RuvB-like 2 1 6954900.0 1809100.0 2111900.0 3033900.0 True False 1751671.1107512754 2955192.683413006 2239230.574950949 1.0 1.6870705152781513 1.2783396159285654 20.740300492990677 -10.221161388612718 4.451858353380864 0.999835412730018 1.4827050656108363 0.650304914408182 0.16686369094472095 117544923.35125855 58.49605231172886 198318.77676700216 0.05712187972057504 6.009503762055344e-11 10.221161388612718 0.4828696528808183 KGTEVQVDDIK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGTEVQVDDIKR 12 2 Q9Y230;Q9Y230-2 Q9Y230 RUVBL2 RuvB-like 2 1 18895400.0 2404000.0 2780400.0 13711000.0 True False 3647043.755941573 2284215.8966356493 11001014.840255216 1.0 0.6263198495807253 3.016419757051979 21.79829607804707 -6.866939628166526 1.1500723145426317 0.792082328676439 3.148541912797247 0.9615370179958218 0.2058807980279919 0.13982789614256372 0.3475671712788062 0.13916581744205353 0.3278615097966515 1.3585022806078837e-07 6.866939628166526 2.356459584120808 up KGTEVQVDDIK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGTEVQVDDIKR 12 2 Q9Y230;Q9Y230-2 Q9Y230 RUVBL2 RuvB-like 2 1 3667100.0 1094200.0 1316900.0 1256000.0 True False 1498755.3096431585 1258715.003594055 959358.6681319748 1.0 0.8398402297528774 0.6401035992729128 20.51533343401107 -6.968143594655337 0.29922257976061517 1.034962616953773 0.43872952307112734 0.9999640649768485 0.0008825211004320411 0.07690977041819382 0.011174664084751845 0.0033265368415793376 0.017928295313744718 1.0761093511761492e-07 6.968143594655337 -0.5962330938826456 KGTEVQVDDIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGTEVQVDDIKR 12 2 Q9Y230;Q9Y230-2 Q9Y230 RUVBL2 RuvB-like 2 1 6643500.0 1809100.0 3117900.0 1716500.0 True False 1504346.8067188896 3101103.253845308 2075412.213800714 1.0 2.061428415306097 1.3796102099138743 20.520705768424953 -10.159840215565973 4.890050121093574 0.9999438674724517 1.7205193126123168 0.5982311725715391 0.278351116766584 0.0001703585315267507 2.9269646339487377e-05 0.269533196668768 0.0898374366351175 6.920855543012297e-11 10.159840215565973 0.7205754451398652 KGTEVQVDDIK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGTEVQVDDIKR 12 2 Q9Y230;Q9Y230-2 Q9Y230 RUVBL2 RuvB-like 2 1 16260100.0 2404000.0 3653100.0 10203000.0 True False 3112025.3899245 3449801.7736670147 8346158.691620715 1.0 1.1085390835293631 2.6819057192278235 21.56942240013952 -6.920849113239704 0.8184165314833808 0.9663360075521035 2.9406375271306966 0.9944133333363983 0.05744476728670408 0.09767457540181079 0.10304802284498213 0.049718394231378554 0.15015809528764645 1.1999161171210184e-07 6.920849113239704 1.9743015195785931 up KGTHFVQLCCQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGTHFVQLCCQR 12 1 Q9HCC0-2;Q9HCC0;D6RD67 Q9HCC0-2 MCCC2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial 0 3199890.0 702880.0 801410.0 1695600.0 False True 921482.4866996022 681842.7518717125 1520155.5773436998 1.0 0.7399410859275388 1.6496847192270745 19.813597221310996 -6.830290002309784 1.3265340808355555 0.8610657295989205 1.674323658633283 0.9064631878009177 0.11700955625994355 0.18045762099428622 0.6209308395247091 0.06925284095540948 0.15937565933642472 1.4781210358446182e-07 6.830290002309784 0.8132579290343626 KGTHFVQLCCQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGTHFVQLCCQR 12 1 Q9HCC0-2;Q9HCC0;D6RD67 Q9HCC0-2 MCCC2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial 0 2595330.0 702880.0 1147900.0 744550.0 False True 962753.7306177869 1097181.9824023207 568702.6244885841 1.0 1.1396289076940507 0.5907041503995574 19.876807282833887 -6.839254511629514 1.2858207699768625 1.0742885517199594 0.5729106239876138 0.9231716860465227 0.06456535267448309 0.16966958465654064 0.5452315702538482 0.03937833235312632 0.09070434288337229 1.4479230717213032e-07 6.839254511629514 -0.5013779277323456 KGTVYLTPYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGTVYLTPYR 10 1 K7EIJ0;K7ENL2;A6NG10;K7EMC9;Q969T9;Q969T9-2 K7EIJ0 WBP2 WW domain-binding protein 2 0 8421100.0 2559200.0 2683000.0 3178900.0 False True 3355135.9833280556 2282706.8582520857 2849977.922162 1.0 0.680361949439618 0.8494373808762962 21.67793980922127 -10.032721774886154 4.795406753633036 1.0000054045626632 0.7648996659118833 0.7205148597931574 0.06902475586062168 95454285.11925322 7.628950454649095 5696.329217733342 0.02362900987938203 9.274237750899815e-11 10.032721774886154 -0.23510573865077988 KGTVYLTPYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGTVYLTPYR 10 1 K7EIJ0;K7ENL2;A6NG10;K7EMC9;Q969T9;Q969T9-2 K7EIJ0 WBP2 WW domain-binding protein 2 0 5594900.0 2559200.0 1175700.0 1860000.0 False True 3505405.3997795386 1123753.686480014 1420706.3079024483 1.0 0.32057738216261344 0.4052901578778304 21.741149870744163 -10.656868340323125 6.680537202921329 1.003249980578409 0.3629337700238641 0.9869121464934808 0.03458384586618597 0.0016783823246573298 8.620645113591508e-05 0.033572410885552594 0.011161888257295204 2.2035943982132e-11 10.656868340323125 -0.6403162105545448 KGVAINFVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGVAINFVK 9 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 154286000.0 44355000.0 36759000.0 73172000.0 False True 58149834.53443107 31274700.48545973 65600863.35538632 1.0 0.537829569694505 1.1281349960943297 25.793271750721804 -6.697821215546996 1.83874268289516 0.7124181351484483 1.126310386252455 0.4074161826345909 0.1951632451819633 0.3999527343532692 2.627406947961633 0.08472834975422143 0.21847856004120444 2.0052973710528176e-07 6.697821215546996 0.41389225110400674 KGVAINFVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGVAINFVK 9 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 86569000.0 27732000.0 13069000.0 45768000.0 False True 26851662.83972934 18287519.853934657 33779987.789431125 1.0 0.6810572575370156 1.2580221936740072 24.67850809679278 -6.756596584300796 1.624922931658838 0.813967737562152 1.2598116631101095 0.6771181252053857 0.13409145731885275 0.2886433351126141 1.5011985276355426 0.06513129759200947 0.1570736321134497 1.7514728745848997e-07 6.756596584300796 0.4458439255479575 KGVAINFVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KGVAINFVK 9 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 66623000.0 20660000.0 24651000.0 21312000.0 False True 31342730.448316492 20251836.450857926 17099673.85861858 1.0 0.6461414229450361 0.5455706511216559 24.901627531088305 -13.999999999999998 0.17644864849254155 2.8166372687990155 0.46268312221623287 0.9995028535302956 0.004345399387350446 12.160804785927773 0.1331229510206069 7.568347798599108 0.07741874873654579 1.0000000000000041e-14 13.999999999999998 -2.3539541465827827 KGVAINFVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGVAINFVK 9 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 100201000.0 44355000.0 29157000.0 26689000.0 False True 60754242.14880491 27868747.330694735 20385607.87720884 1.0 0.45871278029336654 0.33554213098862334 25.856481812244695 -13.999999999999998 0.2080012051683733 4.105025613481549 0.2615732434227959 0.9994889869276519 0.006524223238505946 12.700636634571497 0.14456909473281218 16.101136949913087 0.07399546618469645 1.0000000000000041e-14 13.999999999999998 -3.8434523700587526 KGVAINFVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGVAINFVK 9 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 53644000.0 27732000.0 13616000.0 12296000.0 False True 23060386.735906377 13542647.905435612 14867036.749719542 1.0 0.5872688979820496 0.6447002350819508 24.458913372227055 -10.31622162418837 5.6789642839285435 1.000050256900933 0.6159845665321246 0.9835017857263182 0.023446245190099524 1.4920947324059488e-05 1.7965508726190267e-06 0.02270469039496994 0.00756724309602767 4.828123558889221e-11 10.31622162418837 -0.38406569036880844 KGVAINFVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGVAINFVK 9 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 80224000.0 20660000.0 32017000.0 27547000.0 False True 26744777.269484248 30235225.80479505 22533728.656088963 1.0 1.130509538372316 0.8425468804258809 24.672753853180755 -6.783477996392202 1.522222862025749 1.0735635616412695 0.8400078515523663 0.7795403626311964 0.05527870367905537 0.2452044611654992 1.1224242648157527 0.028595336211174043 0.06728227639183512 1.646349376801655e-07 6.783477996392202 -0.2335557100889032 KGVAINFVK(ub)NDDIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGVAINFVKNDDIR 14 2 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 4838000.0 1099200.0 1651900.0 2086900.0 True False 914033.5028165387 1643000.886823522 2523261.1412646165 1.0 1.7975280793983093 2.7605783961849766 19.801887520969004 -6.968610388193123 0.28945773419208903 0.8106018503063877 3.777236479043375 0.9999694241687854 0.0039802217467340304 0.07675621865196543 0.010635850666858626 0.016874177408957657 0.08738865690653759 1.0749533359527263e-07 6.968610388193123 2.9666346287369874 KGVAINFVK(ub)NDDIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KGVAINFVKNDDIR 14 2 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 22682100.0 2545100.0 0.0 20137000.0 True False 3294682.121421317 0.0 16472272.62306832 1.0 0.0 4.999654599747008 21.65170784670565 -6.854687977146985 1.2121598298049048 0.46335862814617257 5.218456247552111 0.9468637220577056 0.4979282999323367 0.15237612060115083 0.42847841211509324 0.3209914052602212 0.7454173401036652 1.397371955187206e-07 6.854687977146985 4.755097619405938 up KGVAINFVTEEDKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGVAINFVTEEDKR 14 2 Q14240-2;Q14240 Q14240-2 EIF4A2 Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 36913000.0 0.0 18661000.0 18252000.0 False True 0.0 15876851.540008295 16363458.125546826 0.0 KGVAINFVTEEDKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGVAINFVTEEDKR 14 2 Q14240-2;Q14240 Q14240-2 EIF4A2 Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 21527000.0 0.0 11363000.0 10164000.0 False True 0.0 10860945.087583903 7763472.534150792 0.0 KGVAINMVTEEDK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 27868400.0 9255100.0 11752000.0 6861300.0 True False 12133525.7265159 9998647.408937214 6151358.494237031 1.0 0.8240512802545721 0.5069720568354019 23.53249548994373 -6.962030096015471 0.405810394381444 1.0163515770121887 0.30298451661958803 0.9998382382027922 0.002594683050621597 0.07898374714898442 0.01850931487410505 0.004079681567385929 0.026510785165800035 1.0913647037421829e-07 6.962030096015471 -0.7133670603926007 KGVAINMVTEEDK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 36432000.0 13021000.0 11621000.0 11790000.0 True False 12607655.482335048 16261325.9027144 8701845.307581563 1.0 1.2897977681495671 0.6902032911490935 23.58779668147271 -6.775294355671177 1.5543300948566252 1.1650944444671039 0.6861462337552353 0.7503451611857672 0.12232986670571996 0.25795467244010584 1.2305821534778418 0.062011665420448725 0.14689988004319565 1.6776665455677544e-07 6.775294355671177 -0.47894821071186855 KGVAINMVTEEDK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 2 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 351955500.0 82322200.0 48764300.0 220869000.0 True False 124888795.95897403 40061929.66778507 177214145.33967823 1.0 0.32078081432497285 1.4189755292211566 26.89606881459194 -6.739444306214202 1.6891850675192 0.5955993283105363 1.4194849348004088 0.6022701917227304 0.2853809481595659 0.3188128069276778 1.7860391738549948 0.1336777562242343 0.32817592781589117 1.8220307147480252e-07 6.739444306214202 0.8238856064898725 KGVAINMVTEEDK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 25416000.0 9255100.0 9085800.0 7075100.0 True False 12676960.579673184 8684359.313277284 5404107.096258391 1.0 0.6850505891137803 0.4262935947693631 23.595705551466622 -7.350682017496448 0.1903774976232204 1.2017850769693537 1.9654102135006197e-11 0.9999780027253361 0.001100235931608992 0.11431729736123394 0.01303928338177351 0.023070811441774714 0.051800419163497965 4.45982669264508e-08 7.350682017496448 -1.2017850769496996 down KGVAINMVTEEDK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 39670300.0 13021000.0 19570000.0 7079300.0 True False 10827538.428106043 19464572.52565913 8559548.89901509 1.0 1.7976913824783236 0.7905350746016543 23.368201956906987 -6.695627024939025 1.846564629057175 1.4974396734290967 0.793772485647558 0.39684899065299317 0.3369916089911361 0.4046673667688436 2.679444052571628 0.14576813322012025 0.3769000745738576 2.0154543927955587e-07 6.695627024939025 -0.7036671877815387 KGVAINMVTEEDK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 2 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 342309100.0 82322200.0 48851900.0 211135000.0 True False 106567710.7131626 46133248.82072858 172710596.4280446 1.0 0.4329008150029677 1.620665352312128 26.667195136684388 -6.776880270461505 1.5481092872791573 0.6775930433552272 1.6291575648863312 0.7561718513469189 0.23952112092557995 0.2554494682970264 1.2090326918506953 0.12188974516532841 0.28835773281991556 1.6715513765320336e-07 6.776880270461505 0.951564521531104 KGVAINMVTEEDKR ddPTM_RPMI8226_Bortezomib_1h_R1 2 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 76710000.0 23182700.0 26694300.0 26833000.0 False True 30392744.201586127 22711614.493566398 24056578.56031106 1.0 0.7472709388440525 0.7915237400331755 24.857223607820686 -10.346689229274222 5.744398614995417 1.0000407367921456 0.76939733943862 0.973122930156412 0.018066130433699798 9.427021549222267e-06 1.0721597811345704e-06 0.01749554045811235 0.005830818525010406 4.501018217631061e-11 10.346689229274222 -0.23064339735352557 KGVAINMVTEEDKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 42309700.0 11151000.0 6070700.0 25088000.0 False True 10797017.60874879 8494762.168282278 18516700.176132847 1.0 0.7867693168712625 1.7149828635204616 23.364129525186904 -6.846273217547215 1.2529760855526648 0.8864801450338942 1.7494984258331985 0.9347003489747167 0.1014402466365139 0.1616039811277846 0.49010950913551377 0.06340779732335056 0.14641907963154857 1.424711016433722e-07 6.846273217547215 0.8630182807993043 KGVAINMVTEEDKR ddPTM_RPMI8226_Bortezomib_8h_R1 2 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 185659200.0 21498100.0 133969400.0 30191700.0 False True 32614189.421633765 110061513.86230019 24224297.26150781 1.0 3.374651212067033 0.7427533135451546 24.958996437085926 -6.669024446083312 1.940781097340491 2.516996751678652 0.7534279111553214 0.27474823172431484 1.0089269692535558 0.4633655126991701 3.3638726303852358 0.41864784663137766 1.1199673107830956 2.1427699829450385e-07 6.669024446083312 -1.7635688405233307 KGVAINMVTEEDKR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 KGVAINMVTEEDKR 14 2 P60842 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 73930320.0 23182700.0 24122720.0 26624900.0 False True 31753970.678910993 23056898.467232455 20336646.977027886 1.0 0.7261107185737061 0.6404442198006506 24.920433669343577 -13.999999999999998 0.16271508861871234 2.3568946705114087 0.558702683057641 0.9995294905218629 0.0033262543690936995 12.028884392294973 0.12756041784543076 5.150490871168006 0.0747622408847648 1.0000000000000041e-14 13.999999999999998 -1.7981919874537677 KGVEGLIDIENPNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGVEGLIDIENPNR 14 1 Q13442 Q13442 PDAP1 28 kDa heat- and acid-stable phosphoprotein 0 5270930.0 776630.0 1575600.0 2918700.0 False True 1018169.4508956177 1340526.6216406967 2616700.9221473564 1.0 1.3166046383158738 2.570005336386408 19.957546254139338 -6.9451120134208955 0.6101531154453105 0.9861390155569979 2.965761388303379 0.9987597084848641 0.023874799532588427 0.08550992013213261 0.0445573266528911 0.024264665696115673 0.10569568505883223 1.1347181109399735e-07 6.9451120134208955 1.9796223727463809 up KGVEGLIDIENPNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGVEGLIDIENPNR 14 1 Q13442 Q13442 PDAP1 28 kDa heat- and acid-stable phosphoprotein 0 4115530.0 776630.0 1397800.0 1941100.0 False True 1063771.0986365974 1336040.574093531 1482652.1582093767 1.0 1.255947426853289 1.3937699192144308 20.02075631566223 -12.2608653296886 0.0905134220177281 3.961714856521742e-16 1.769392389705502 0.9998851064068095 0.0017487608262880096 6.408239101022058 0.07030917953255081 1.5062499734016601 0.2887977087137278 5.484470064061921e-13 12.2608653296886 1.7693923897055015 KGVLFGVPGAFTPGCSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGVLFGVPGAFTPGCSK 17 1 P30044-2;P30044;P30044-3 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 18983900.0 6982400.0 3568900.0 8432600.0 False True 9153994.017657796 3036434.031463239 7560075.443210939 1.0 0.33170592263945586 0.8258772540846943 23.125969918429206 -9.926538064856457 6.514670502406529 1.0000000427805351 0.5787915883622936 0.4920439239261081 0.20174460125881796 1.2535627012778644e-07 2.0776302306426498e-08 0.19533838913555715 0.06511279007188103 1.1843005613804857e-10 9.926538064856457 -0.4212084544182415 KGVLFGVPGAFTPGCSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGVLFGVPGAFTPGCSK 17 1 P30044-2;P30044;P30044-3 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 7153890.0 1884100.0 998890.0 4270900.0 False True 1824290.2768041987 1397751.9861425364 3152223.165746401 1.0 0.7661894622335682 1.7279175391256714 20.79890387535447 -6.8424501147898 1.2708441760053795 0.8756231493014999 1.7611386870436623 0.9285983702143423 0.10943153478960782 0.16596158795447463 0.5195795178500012 0.06748905929154839 0.15560995284261056 1.4373081401901133e-07 6.8424501147898 0.8855155377421624 KGVLFGVPGAFTPGCSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGVLFGVPGAFTPGCSK 17 1 P30044-2;P30044;P30044-3 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 17009800.0 6982400.0 5549200.0 4478200.0 False True 9563981.972265031 5304017.995249549 3420541.391424052 1.0 0.5545826007023936 0.35764824749183083 23.189179979952097 -13.999999999999998 0.1106960074340428 3.1466757806276107 1.210513972784782e-06 0.9997396204776968 0.004335809048893798 12.007025467842997 0.10106113825613917 5.75330298607734 0.31757577616205485 1.0000000000000041e-14 13.999999999999998 -3.146674570113638 KGVLFGVPGAFTPGCSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGVLFGVPGAFTPGCSK 17 1 P30044-2;P30044;P30044-3 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 4725400.0 1884100.0 1422900.0 1418400.0 False True 1566712.6297822443 1415234.555276465 1714980.8820593844 1.0 0.9033147039053147 1.0946365335024764 20.579309150788745 -6.769291249412451 1.5769850046815759 0.9444953023909977 1.0956890135619222 0.727939766603336 0.04074081664618303 0.2675600327795562 1.3130346928819798 0.020364149616392588 0.04851030082029972 1.7010173783764467e-07 6.769291249412451 0.1511937111709245 KGVNLPGAAVDLPAVSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KGVNLPGAAVDLPAVSEK 18 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 72602100.0 4076400.0 38634700.0 29891000.0 False True 5344199.875913753 32870553.3568811 26798166.054718357 1.0 6.150696852681035 5.014439331787978 22.349542535705954 -10.045235424125108 6.685481175163241 0.9999981030830005 5.582568092234517 0.9559222398682153 0.46387519043133724 1.3114764508368045e-05 1.8740467979439011e-06 0.4491454088221331 0.1497150739382745 9.010825426860955e-11 10.045235424125108 4.582569989151517 KGVNLPGAAVDLPAVSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KGVNLPGAAVDLPAVSEK 18 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 96572300.0 34396000.0 11574000.0 50602300.0 False True 33304117.807418514 16195558.557612648 37348039.59353976 1.0 0.48629297587954956 1.1214240776322397 24.989197231089534 -6.691524299625672 1.8612792296823832 0.6783985721003964 1.11925492690686 0.37750182920351427 0.21719488695797062 0.41336770811391077 2.777745983130327 0.09331668355342851 0.2425122452245604 2.034584353691784e-07 6.691524299625672 0.44085635480646346 KGVNLPGAAVDLPAVSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KGVNLPGAAVDLPAVSEK 18 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 68356900.0 4076400.0 30411600.0 33868900.0 False True 5583555.240567873 29067914.95428732 25869763.371890973 1.0 5.205986813400091 4.63320630983135 22.412752597228845 -10.52534223797196 5.567354947674751 0.9910740779620427 4.919596561615718 0.9842364358017665 0.23383666139298298 0.025627976820148314 0.0021849701607065384 0.2239732546587922 0.07547045794231179 2.9830309684349726e-11 10.52534223797196 3.928522483653675 KGVNLPGAAVDLPAVSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KGVNLPGAAVDLPAVSEK 18 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 44420900.0 34396000.0 5161300.0 4863600.0 False True 28601798.0011624 5133495.052462166 5880556.273254385 1.0 0.17948155050439615 0.2056009301588451 24.76960250652381 -10.783853130782326 10.429580090801872 1.0044957197252071 0.192541240925193 0.9992158381397515 0.010663192091905398 0.0011079810841953973 2.2962210580347588e-05 0.010262419086565508 0.003441530449113354 1.6449279090280252e-11 10.783853130782326 -0.8119544788000141 KHFPSVNWLISYSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KHFPSVNWLISYSK 14 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 3347000.0 1642400.0 1704600.0 0.0 False True 1590262.9110043063 2385255.669371568 0.0 1.0 1.499912783519045 0.0 20.60083386882523 -6.8376763308900665 1.4347887839640912 1.2688591034532635 5.147802389149687e-22 0.8762626832964605 0.21935193496314326 0.18671325318455098 0.7715539996996219 0.12254082488513598 0.2629335497700863 1.45319424442057e-07 6.8376763308900665 -1.2688591034532635 down KHFPSVNWLISYSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KHFPSVNWLISYSK 14 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 29190000.0 6104000.0 10136000.0 12950000.0 False True 7901748.327828253 9571922.689739924 10593232.878220942 1.0 1.2113676989723499 1.3406188654368885 22.913740466262862 -11.350956491077785 0.06384922594494216 7.568748926974506e-18 1.9499519914871906 0.9999737792856287 0.0007188991086139024 4.200810363042901 0.043244462594162585 1.01543119682949 0.41206204626757165 4.457008978120412e-12 11.350956491077785 1.9499519914871906 KHLEINPDHPIVETLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KHLEINPDHPIVETLR 16 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 25288800.0 3098800.0 12073000.0 10117000.0 False True 4062556.808821884 10271755.4601854 9070189.88911666 1.0 2.528396756909387 2.2326309060886604 21.953956556440648 -10.267589091668802 5.035026244524488 0.9997166438714815 2.380513831499645 0.9667205049555251 0.12074590297730775 0.0003841429367958945 5.587817544570834e-05 0.1169344268620586 0.03897057261251527 5.400213228066577e-11 10.267589091668802 1.3807971876281633 KHLEINPDHPIVETLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KHLEINPDHPIVETLR 16 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 27374600.0 3098800.0 17996000.0 6279800.0 False True 4244510.101921233 17200877.215186145 4796640.576540745 1.0 4.0525000063965795 1.1300810838851805 22.01716661796354 -6.635980048278502 2.0582327810038192 3.0022608178608623 1.1419974777446875 0.13937829877002372 1.3074059733717565 0.5438009211067424 4.397497532551018 0.5180765911163274 1.4484291096358328 2.3121710101123615e-07 6.635980048278502 -1.8602633401161748 KHLEINPDHSIIETLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KHLEINPDHSIIETLR 16 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 13349900.0 1432500.0 7280700.0 4636700.0 False True 1962133.9618569035 6959014.5999447545 3541606.955834019 1.0 3.5466562096295178 1.8049771446198049 20.903992112160118 -9.376344299067977 8.721594510670407 1.0000018762949532 2.675816677124847 0.5524523187649769 0.7110375008284179 0.0 0.0 0.6884590998086737 0.22948636660289118 4.2039321778864545e-10 9.376344299067977 1.6758148008298939 KHLLIGVSSDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KHLLIGVSSDR 11 1 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 3563210.0 974970.0 349540.0 2238700.0 False True 944020.1110215968 489113.14482702024 1652317.3104395973 1.0 0.518117293388711 1.7502988454891046 19.848458068941376 -6.80063622195764 1.4533371837151423 0.7343387956180093 1.767571964372988 0.8340113565586293 0.2065599777452605 0.21985041062978883 0.9167091988846223 0.1118087367613018 0.25992303978778164 1.582573094779016e-07 6.80063622195764 1.0332331687549785 KHPDASVNFSEFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KHPDASVNFSEFSK 14 1 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 78405000.0 14323000.0 33551000.0 30531000.0 False True 18777591.704129312 28545321.58077366 27371944.994031876 1.0 1.5201801184385302 1.4576919886916389 24.162508708070913 -10.527570664944864 6.125547793727329 0.9993757427808441 1.488936053565084 0.9878978025981594 0.025510672143452543 0.0002177471876869872 1.679359574795309e-05 0.024730212175273467 0.008233534030179082 2.967763813245086e-11 10.527570664944864 0.4895603107842399 KHPDASVNFSEFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KHPDASVNFSEFSK 14 1 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 46046200.0 9629800.0 4720400.0 31696000.0 False True 9324107.27008602 6605280.336560808 23393866.74038213 1.0 0.7084088744615945 2.5089658519304345 23.152534171509842 -6.865391559602967 1.158264156761846 0.8389074703209504 2.6055474321259537 0.9598595958816458 0.15809532140681867 0.14134634264290216 0.3573284650459289 0.10620389679995781 0.2496060552521992 1.3633533838370356e-07 6.865391559602967 1.7666399618050033 up KHPDASVNFSEFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KHPDASVNFSEFSK 14 1 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 114352100.0 4420800.0 101010000.0 8921300.0 False True 6706676.803771428 82983976.30526777 7158001.144655301 1.0 12.373337605683133 1.0672947801256916 22.677166649261014 -6.644804426587657 2.0269844484547943 8.410290550631856 1.1145512763271352 0.1732699085136955 4.860517842568713 0.5214017419611336 4.099989066646233 1.9487147912819838 5.383093074103136 2.2656643618965379e-07 6.644804426587657 -7.295739274304721 KHPDASVNFSEFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KHPDASVNFSEFSK 14 1 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 57724000.0 14323000.0 18056000.0 25345000.0 False True 19618600.164521072 17258226.21679266 19359032.996659957 1.0 0.8796869334236707 0.9867693328940703 24.225718769593804 -10.262132338261408 5.254802818279454 1.0000088560997509 0.9332281334401149 0.34142474134247347 0.04371620652259448 4.53630990207402e-06 6.369910182984907e-07 0.04233364875404525 0.014109344985109283 5.468493015245331e-11 10.262132338261408 -0.06678072265963597 KHPDASVNFSEFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KHPDASVNFSEFSK 14 1 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 18716900.0 9629800.0 4190500.0 4896600.0 False True 8007605.372473357 4167924.9447508804 5920456.420679629 1.0 0.5204957975424691 0.7393541696037578 22.93293944694412 -10.334389251495633 5.824726499993979 1.0000491234886113 0.6299249835731127 0.7922010026496754 0.08934855624772899 5.700480435848603e-05 6.514244814450285e-06 0.08652281277618072 0.028837122529593705 4.630317254508477e-11 10.334389251495633 -0.37012413991549864 KHPDASVNFSEFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KHPDASVNFSEFSK 14 1 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 19008600.0 4420800.0 9617700.0 4970100.0 False True 5722812.746995939 9082466.540362222 4065592.797532498 1.0 1.5870633798266172 0.7104186310598122 22.448292971353464 -6.726242533175878 1.7368549403625844 1.3547635986190287 0.7112818638189408 0.5417735617438857 0.24686932235108916 0.34333875628092775 2.0272947075191357 0.11271708352097089 0.280905580734853 1.8782675991683178e-07 6.726242533175878 -0.643481734800088 KHPDSSVNFAEFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KHPDSSVNFAEFSK 14 1 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 37176800.0 1772800.0 21304000.0 14100000.0 False True 2324157.96781962 18125526.242341604 12641067.256750507 1.0 7.7987496948608195 5.43898798264972 21.148276698154785 -9.324837560879478 8.979936538227339 1.0000000011064485 6.618868838749627 0.8831724454974663 0.9633686849151678 0.0 0.0 0.9327777182322387 0.3109259060774128 4.7332826477901e-10 9.324837560879478 5.618868837643179 KHPDSSVNFAEFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KHPDSSVNFAEFSK 14 1 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 24617800.0 6497900.0 1850900.0 16269000.0 False True 6291627.721270637 2589974.022315988 12007660.840461772 1.0 0.4116540483728629 1.9085141989355887 22.585001877622886 -6.80010161997799 1.4556715346460778 0.6754270512833338 1.92918782450494 0.8324121038100962 0.25206552271975996 0.2206137755147599 0.9229301856285195 0.1362295468761467 0.3167755135561534 1.5845223888318229e-07 6.80010161997799 1.2537607732216063 KHPDSSVNFAEFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KHPDSSVNFAEFSK 14 1 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 35868800.0 1772800.0 16522000.0 17574000.0 False True 2428252.068118615 15792003.409052316 13423383.147891203 1.0 6.503444850883129 5.528002353681306 21.211486759677676 -10.357153580092211 6.2464071573298785 0.9995159915776632 6.015723602282218 0.9724164775224765 0.3982227319284497 0.0026843059265348424 0.00027625352344939956 0.3855958296210018 0.12852583407000814 4.393862072755324e-11 10.357153580092211 5.016207610704555 KHQIIHTGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KHQIIHTGEK 10 1 P17020 P17020 ZNF16 Zinc finger protein 16 0 80159000.0 18030000.0 23266000.0 38863000.0 False True 23637504.6027684 19794803.49015769 34841829.560219504 1.0 0.8374320311222423 1.474006251748709 24.494574403312665 -6.838978792385978 1.2872117721272878 0.9135049642219691 1.4945133152318626 0.9226713121480831 0.07509525762637916 0.1699947787905985 0.547594921839608 0.04575449565536089 0.10537760239239341 1.4488426021859597e-07 6.838978792385978 0.5810083510098935 KHQIIHTGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KHQIIHTGEK 10 1 P17020 P17020 ZNF16 Zinc finger protein 16 0 64185000.0 18030000.0 21550000.0 24605000.0 False True 24696178.242429323 20597849.743679784 18793805.755881593 1.0 0.8340500923455275 0.7610005714808478 24.557784464835557 -13.999999999999998 0.11138994443211098 1.798866284444595 0.6296360875494139 0.9997360062723032 0.0016247450065524525 12.004642478816798 0.10150164733384144 2.151351612372324 0.1166417843851778 1.0000000000000041e-14 13.999999999999998 -1.1692301968951813 KHQIIHTGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KHQIIHTGEK 10 1 P17020 P17020 ZNF16 Zinc finger protein 16 0 26203890.0 17373100.0 8830790.0 0.0 False True 14446502.408826435 8783216.781495424 0.0 1.0 0.6079822321650055 0.0 23.78421691346197 -7.632154157345555 0.6675772219520519 0.9976236258597152 1.988852385307186e-21 0.9872118162049706 0.04652418725506916 0.12114667247886267 0.14801549383756163 0.04247171293601281 0.0774379090959984 2.3326299240470168e-08 7.632154157345555 -0.9976236258597152 down KHSQFIGYPITLYLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KHSQFIGYPITLYLEK 16 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 20082300.0 6238600.0 8086900.0 5756800.0 False True 8178865.014688335 6880366.042489302 5161141.559124918 1.0 0.8412372658226939 0.6310339576281158 22.963469222847017 -6.967248063355059 0.31710742239806294 1.0297821205882012 0.4357378334698033 0.9999522678212764 0.0010440280121411876 0.07720614844743125 0.012212060290771133 0.003224472511985322 0.018537974050036817 1.0783306178783705e-07 6.967248063355059 -0.5940442871183979 KHSQFIGYPITLYLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KHSQFIGYPITLYLEK 16 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 28837300.0 8412500.0 6517500.0 13907300.0 False True 8145449.792269678 9119971.738313498 10264560.919943081 1.0 1.1196400408690355 1.2601588840047255 22.95756293598903 -6.969003357248023 0.28097435694846096 0.9694039427838517 1.4146825913221335 0.9999735277848121 0.0005470155656396412 0.07662746532992777 0.010182714243498531 0.002581067963083483 0.012882078565104755 1.073981110060085e-07 6.969003357248023 0.4452786485382818 KHSQFIGYPITLYLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KHSQFIGYPITLYLEK 16 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 100105000.0 12591000.0 40280000.0 47234000.0 False True 19101467.525399476 33091719.290923525 37898179.196602374 1.0 1.732417640001797 1.9840454219660693 24.18718014594295 -10.719769317763589 0.21867012738855604 1.148714748976642e-13 2.154679216222874 0.9992942441438266 0.011089002143510428 2.5474528478093132 0.11450996168786434 1.4764392461651146 0.13762576568563023 1.9064731017656584e-11 10.719769317763589 2.154679216222759 KHSQFIGYPITLYLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KHSQFIGYPITLYLEK 16 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 23295200.0 6238600.0 8185500.0 8871100.0 False True 8545179.011825807 7823837.544171268 6775928.886039463 1.0 0.9155849787750188 0.792953415798797 23.02667928436991 -6.965784274748413 0.3443318260025566 1.01265109640249 0.6917850289432697 0.9999284015948804 0.0007192539716766399 0.07769588809885124 0.013927468109485716 0.0017091608730827423 0.010581367447636523 1.0819712608235265e-07 6.965784274748413 -0.3208660674592203 KHSQFIGYPITLYLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KHSQFIGYPITLYLEK 16 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 14385200.0 8412500.0 2920300.0 3052400.0 False True 6995366.4869397115 2904567.7642658358 3690642.7272969987 1.0 0.4152130942229601 0.527583899169171 22.737968211423308 -10.004240282724318 6.066132324055673 1.0000004816351549 0.47139849669647166 0.9672179714959616 0.04587518901748882 2.987818600492503e-07 4.9100401395958325e-08 0.04441850114018772 0.01480615358904897 9.902838975199628e-11 10.004240282724318 -0.5286019849386832 KHSQFIGYPITLYLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KHSQFIGYPITLYLEK 16 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 81911100.0 12591000.0 35621000.0 33699100.0 False True 16299297.705715215 33638660.03662447 27566209.581965618 1.0 2.0638103950226854 1.6912513704378658 23.9583064680354 -10.117964268455605 4.5902725916363725 0.9999263314458694 1.8775308827475474 0.8809141387201226 0.15209658497641776 23945291.99862404 26390346.005322535 15645.817682234225 0.052066702905991046 7.621417125955077e-11 10.117964268455605 0.877604551301678 KIAFAITAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KIAFAITAIK 10 1 P62269;A0A0G2JQH2;Q5GGW2 P62269 RPS18 40S ribosomal protein S18 0 13541100.0 5611300.0 4520100.0 3409700.0 False True 7356468.639906502 3845718.6992118037 3056896.952151926 1.0 0.5227669534741171 0.4155386370532775 22.810581958118775 -13.999999999999998 0.2097928237811638 3.7576608057905427 0.3522542278129843 0.999489896193224 0.0057376982237993136 12.741810127530403 0.14517781623715648 14.482124517142559 0.06360891663235144 1.0000000000000041e-14 13.999999999999998 -3.4054065779775584 KIAFAITAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIAFAITAIK 10 1 P62269;A0A0G2JQH2;Q5GGW2 P62269 RPS18 40S ribosomal protein S18 0 10339300.0 4442600.0 2116000.0 3780700.0 False True 4301572.094756291 2960929.8347942266 2790421.2514311792 1.0 0.6883366754223795 0.6486980085333831 22.0364325870007 -13.999999999937803 0.29075141123665654 3.696998165115097 0.6379778774722995 0.9996291430900718 0.0030253341724663448 16.01043162938983 0.1710102077843005 25.838829724651625 0.0149197902283612 1.0000000001432147e-14 13.999999999937803 -3.0590202876427974 KIAFAITAIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KIAFAITAIK 10 1 P62269;A0A0G2JQH2;Q5GGW2 P62269 RPS18 40S ribosomal protein S18 0 118809000.0 27541000.0 33799000.0 57469000.0 False True 41781710.5167998 27767304.37720767 46110226.96044245 1.0 0.664580363842281 1.1035983541626957 25.316368220848 -6.702512860093995 1.821846223644545 0.7922334048268959 1.1023584205588317 0.42953541857956523 0.14152069821010319 0.3903207557107444 2.520373953088158 0.06192996879155512 0.15877903972641458 1.983750914204495e-07 6.702512860093995 0.31012501573193585 KIAFAITAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KIAFAITAIK 10 1 P62269;A0A0G2JQH2;Q5GGW2 P62269 RPS18 40S ribosomal protein S18 0 17141200.0 5611300.0 6188200.0 5341700.0 False True 7685949.249680731 5914784.862359129 4080100.4757647887 1.0 0.7695581469790247 0.5308518626940287 22.873792019641666 -6.970682982879549 0.24132051493554407 1.0843212508036308 0.20917326693656885 0.9999872285601868 0.0006844808676902887 0.07608174112973791 0.008233325645457432 0.005653040921707683 0.023217066049589938 1.0698355302287264e-07 6.970682982879549 -0.8751479838670619 KIAFAITAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIAFAITAIK 10 1 P62269;A0A0G2JQH2;Q5GGW2 P62269 RPS18 40S ribosomal protein S18 0 147126000.0 27541000.0 71682000.0 47903000.0 False True 35652367.41427227 67692833.68645786 39185145.526287034 1.0 1.8986911275731784 1.0990895799699554 25.087494542940448 -10.169916402195321 4.236764424843792 0.999858719122775 1.4988903538095713 0.3416899378544386 0.3264359650477343 46876164.27252419 56260810.4140568 53076.97875953979 0.111747716344217 6.762131278459824e-11 10.169916402195321 0.49903163468679623 KIDENENNGVLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIDENENNGVLKK 13 2 Q5TAQ9;V9GY54 Q5TAQ9 DCAF8 DDB1- and CUL4-associated factor 8 1 2150070.0 712520.0 549870.0 887680.0 True False 689901.4426137286 769435.9585341684 655169.9781708231 1.0 1.115283881157168 0.9496573535035331 19.396030751677994 -6.719535934595575 1.760950540715993 1.0701731027484802 0.949922122724511 0.5102928510013118 0.048514847654992886 0.3562452064148527 2.1586841493357247 0.021877282876502164 0.05495087903191854 1.90749788638485e-07 6.719535934595575 -0.12025098002396917 KIDENENNGVLK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KIDENENNGVLKK 13 2 Q5TAQ9;V9GY54 Q5TAQ9 DCAF8 DDB1- and CUL4-associated factor 8 1 1831430.0 712520.0 562710.0 556200.0 True False 592491.9499880278 559678.5695408107 672498.8484217632 1.0 0.9446180147293475 1.135034574622241 19.17643602711227 -6.8288901825854165 1.3329862205051464 0.9703846404761794 1.1400388895631546 0.9036128133820243 0.02482839548649764 0.18218556581963485 0.6335163537499361 0.014626649302534277 0.033659656947322834 1.4828930079129372e-07 6.8288901825854165 0.16965424908697513 KIDENENNGVLK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIDENENNGVLKK 13 2 Q5TAQ9;V9GY54 Q5TAQ9 DCAF8 DDB1- and CUL4-associated factor 8 1 4222270.0 861590.0 868580.0 2492100.0 True False 1115345.2394779727 820242.7594568157 2038563.37110536 1.0 0.7354160222539909 1.8277420290595325 20.089058914616594 -6.842713086696241 1.2697211718831456 0.8592579249379357 1.8656456640436585 0.9290197960277231 0.12395940363453266 0.16565504534053943 0.5176024551539996 0.07651561106901175 0.1764279542615934 1.436438091716518e-07 6.842713086696241 1.0063877391057228 KIDFLTK(ub)QMEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIDFLTKQMEK 11 2 Q99471;H3BPF6;H3BMQ1;Q99471-3 Q99471 PFDN5 Prefoldin subunit 5 1 10891700.0 5733400.0 5158300.0 0.0 True False 5551396.355304494 7218036.090179145 0.0 1.0 1.3002199137307386 0.0 22.40441927078586 -6.882943581326604 1.333743809104143 1.1566308866510546 5.407471847423577e-19 0.9330338021990638 0.14384141027935793 0.14661533608193628 0.5242019096365357 0.08757837935293761 0.17787009484897787 1.3093520082947479e-07 6.882943581326604 -1.1566308866510546 down KIDFLTK(ub)QMEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KIDFLTKQMEK 11 2 Q99471;H3BPF6;H3BMQ1;Q99471-3 Q99471 PFDN5 Prefoldin subunit 5 1 18539500.0 8283000.0 5921700.0 4334800.0 True False 12565916.568412667 4864926.368546726 3478024.8799896687 1.0 0.38715252819486656 0.276782426578614 23.58301257064511 -13.999999999999998 0.24111252422267856 5.078441322520301 0.2284951714493 0.999526819551312 0.00691998618623746 13.662956539811901 0.15540726720549233 26.847518578296008 0.053580742204189645 1.0000000000000041e-14 13.999999999999998 -4.849946151071001 KIDFLTK(ub)QMEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIDFLTKQMEK 11 2 Q99471;H3BPF6;H3BMQ1;Q99471-3 Q99471 PFDN5 Prefoldin subunit 5 1 16133100.0 8283000.0 6058900.0 1791200.0 True False 10722506.7823397 5721716.888798856 1465219.9792640423 1.0 0.5336174651083179 0.1366490139859184 23.35413889273756 -7.92932207497645 0.38828286073632995 1.0623296998150897 1.6124377264283978e-17 0.9978978502837191 0.01617748312124102 0.10365330854859911 0.0782599576544252 0.04272224350218474 0.08200964638511085 1.1767329787448546e-08 7.92932207497645 -1.0623296998150897 down KIEEIK(ub)DFLLTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIEEIKDFLLTAR 13 2 P63173;J3KT73;J3QL01;J3KSP2 P63173 RPL38 60S ribosomal protein L38 1 16426200.0 2720100.0 3181100.0 10525000.0 True False 2633751.91440746 4451329.81921735 7768186.756768107 1.0 1.690109761237253 2.949475504611371 21.328688027025567 -6.961796590556121 0.4093276498563579 0.9375060235187775 3.748764421128467 0.9998311361029718 0.01048808567923102 0.07906548803039519 0.018805244526041865 0.0162137677209048 0.10517060021570497 1.0919516514209815e-07 6.961796590556121 2.8112583976096897 KIEEIK(ub)DFLLTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KIEEIKDFLLTAR 13 2 P63173;J3KT73;J3QL01;J3KSP2 P63173 RPL38 60S ribosomal protein L38 1 11469200.0 2720100.0 2750100.0 5999000.0 True False 2261883.6708617792 2735284.665447892 7253363.16375794 1.0 1.2092950228540034 3.2067799317877403 21.109093302459843 -6.926969100052913 0.7712649492523345 0.9659678735382254 3.5869002949055893 0.9959083173626638 0.0636228644634149 0.09424231890209839 0.08561594808616121 0.05695082157289402 0.18384183106922206 1.1831257318395296e-07 6.926969100052913 2.620932421367364 up KIEFSLPDLEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KIEFSLPDLEGR 12 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 0 3510210.0 722550.0 1933400.0 854260.0 False True 947270.0471841525 1644944.2563341744 765869.3698405458 1.0 1.73651036599745 0.8085016222323962 19.85341624141373 -6.695171055672545 1.8476396168542997 1.4594675767853214 0.811453724833826 0.39496770976400075 0.3111697876766148 0.4056172501768916 2.688391788311358 0.13452078404029613 0.348087164964483 2.017571545771947e-07 6.695171055672545 -0.6480138519514953 KIEFSLPDLEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KIEFSLPDLEGR 12 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 0 5072050.0 722550.0 2194000.0 2155500.0 False True 989696.261179549 2097061.8254122236 1646415.293915983 1.0 2.1188943594804366 1.6635561419154368 19.91662630293662 -10.192119296248903 4.940929774892596 0.9999091540316807 1.891225250699488 0.8362785878240853 0.18589104890914213 0.00018604531589142418 3.042008010239107e-05 0.18000638381289089 0.059996078052078045 6.425112018239937e-11 10.192119296248903 0.8913160966678073 KIEFVVVGPEAPLAAGIVGNLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KIEFVVVGPEAPLAAGIVGNLR 22 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 146283000.0 41301000.0 48653000.0 56329000.0 False True 62656636.50754696 39970492.022375956 45195548.46012227 1.0 0.6379291045659868 0.7213210120954784 25.90096399019047 -10.427957246409145 6.867455470402057 1.0000377729064158 0.6796250583307348 0.951642288007631 0.03404460368743547 1.969142811457242e-05 1.6402409996985309e-06 0.0329674206066942 0.010987848592472434 3.732869037611798e-11 10.427957246409145 -0.320412714575681 KIEFVVVGPEAPLAAGIVGNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KIEFVVVGPEAPLAAGIVGNLR 22 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 6573250.0 3557600.0 744450.0 2271200.0 False True 2958302.0284025837 740439.5000882439 2746097.419157695 1.0 0.2502920570581715 0.9282681054173924 21.496337921502413 -10.838404507763137 10.125489950102464 1.0094910056689592 0.5892800812379336 0.32855699531636484 0.27678256271809726 0.05784111587374984 0.0009231005506456232 0.2613917716387121 0.08933118799398336 1.4507597308382376e-11 10.838404507763137 -0.4202109244310256 KIEFVVVGPEAPLAAGIVGNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIEFVVVGPEAPLAAGIVGNLR 22 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 92554000.0 41301000.0 24065000.0 27188000.0 False True 53464958.66442254 22725761.595164828 22240062.9724379 1.0 0.4250589949541539 0.4159745659213839 25.67209031228292 KIEPFYK(ub)GGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIEPFYKGGK 10 2 Q12788;H3BN88 Q12788 TBL3 Transducin beta-like protein 3 1 9182940.0 952580.0 882260.0 7348100.0 True False 1233133.5881590182 833161.4554311297 6010821.197872987 1.0 0.675645739789621 4.874428249778453 20.233897667957777 -6.888244848856401 1.0326851433512996 0.7648113439789538 5.223416422057296 0.9797518093630464 0.27142643446070563 0.12057975877200015 0.23024631328937542 0.20070943956403797 0.4973236994915858 1.2934663984685344e-07 6.888244848856401 4.458605078078342 up KIHPQTIIAGWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KIHPQTIIAGWR 12 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 107344000.0 39985000.0 17836000.0 49523000.0 False True 52420722.21529075 15174938.324183477 44398835.01815996 1.0 0.28948357983051703 0.8469710668200054 25.64363389443721 -10.18874007374563 7.466153868766467 1.0000003786724594 0.5682273233257344 0.44438123136165264 0.22759331351845372 1.4345085036057457e-06 1.561339801600732e-07 0.22036647197103518 0.07345542608042788 6.475300480325634e-11 10.18874007374563 -0.43177305534672494 KIHPQTIIAGWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIHPQTIIAGWR 12 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 62259000.0 22393000.0 0.0 39866000.0 False True 21682146.472308505 0.0 29423898.64563585 1.0 0.0 1.3570565388078517 24.37000425077727 -6.709295433766491 1.7979217162474996 0.38476043384152536 1.3537697053407878 0.4616089504019738 0.4214436118802839 0.3765208536566932 2.3721600185052236 0.18657715243017065 0.4743626329960059 1.953010446195347e-07 6.709295433766491 0.9690092714992624 KIHPQTIIAGWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KIHPQTIIAGWR 12 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 113026000.0 39985000.0 38500000.0 34541000.0 False True 54768535.053995244 36798942.69752535 26383127.194224976 1.0 0.6718993425923476 0.4817205201529374 25.706843955960103 -10.185323311408961 0.10533888500303934 1.8203303474792036 1.1729284308079233e-09 0.9999095825324655 0.0020355377370475463 1.872597845767762 0.05189584054549701 0.6709811174645541 0.2681633287010092 6.526445092217171e-11 10.185323311408961 -1.8203303463062752 KIHPQTIIAGWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KIHPQTIIAGWR 12 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 50277000.0 22393000.0 15071000.0 12813000.0 False True 18620771.678102978 14989809.531640714 15492139.05938161 1.0 0.8050047436684872 0.8319815809566866 24.150409526211547 -10.090126660522971 7.304999012995871 1.000000040951425 0.8184931623511553 0.983702490680875 0.011013247705029261 7.346430767026923e-09 9.244642637069265e-10 0.010663533700238651 0.0035545104124362786 8.125934914470313e-11 10.090126660522971 -0.1815068786002696 KIHPQTIIAGWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIHPQTIIAGWR 12 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 514399000.0 96459000.0 225310000.0 192630000.0 False True 124868076.99115106 212771300.43659228 157573316.55071038 1.0 1.703968744963299 1.261918340921331 26.89582945259284 -10.421090861396825 4.944139028313964 0.9993367320954666 1.48294354294237 0.6141128565995979 0.18046632174920482 0.0013211393468256292 0.00015469234309942892 0.17496565020037014 0.05824525489046809 3.792356344736568e-11 10.421090861396825 0.4836068108469035 KILAAIIMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KILAAIIMK 9 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 4146600.0 1192000.0 1282000.0 1672600.0 False True 1562723.5433444188 1090730.5971968593 1499535.3967121213 1.0 0.6979677255406052 0.9595653710463291 20.57563114745512 -10.165174910944732 7.077070347333463 1.0000002115791056 0.828766548805242 0.36357580695933434 0.10679679156708351 3.565987404824455e-07 4.202123641081556e-08 0.10340567668242637 0.0344685162639749 6.836362591484766e-11 10.165174910944732 -0.17123366277386354 KILAAIIMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KILAAIIMK 9 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 3979490.0 1192000.0 847190.0 1940300.0 False True 1632714.6125887793 809758.3445173119 1482041.101732858 1.0 0.49595828828492283 0.9077159537287302 20.63884120897801 -9.9957216708253 7.043118393659721 1.000000025188505 0.7018371210068273 0.41146605542444836 0.16809936300282668 6.648264710516687e-08 9.641951383573519e-09 0.16276152290649123 0.0542538361181684 1.009899899949424e-10 9.9957216708253 -0.2981629041816778 KILEVHIDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KILEVHIDK 9 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 11696800.0 4079600.0 3463200.0 4154000.0 False True 5348395.106902598 2946504.0594478687 3724183.927981675 1.0 0.5509136854240878 0.6963180269115256 22.350674616227714 -10.349682701223047 4.952049312218019 1.0002265833467294 0.623615856167704 0.899335755821919 0.05936107383862592 0.00014858496815168916 1.95124718653226e-05 0.05751032354113099 0.019158704199114765 4.4701006174999736e-11 10.349682701223047 -0.37661072717902544 KILEVHIDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KILEVHIDK 9 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 7897000.0 2404200.0 1797700.0 3695100.0 False True 2327879.9869925464 2515530.984881656 2727242.459376132 1.0 1.0806102543677696 1.1715562978397067 21.150585251868584 -6.969558532394666 0.26851949886415855 0.9769818407268144 1.2779134318639287 0.9999787255714955 0.0003231865472865569 0.07644623328789373 0.009541488231517917 0.0017990469347464646 0.008475846910347053 1.072609076326202e-07 6.969558532394666 0.3009315911371143 KILEVHIDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KILEVHIDK 9 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 28733600.0 5751600.0 12664000.0 10318000.0 False True 8725597.698283501 10404010.255716378 8278642.777459947 1.0 1.1923550243169077 0.9487765839913204 23.05682252778864 -6.696191928934482 1.8444535837848575 1.1198875425543802 0.9495506785348465 0.3995341311082792 0.08125334181941389 0.4034924218968327 2.6659459674038035 0.03518062516301876 0.09090288886930746 2.0128345158763923e-07 6.696191928934482 -0.17033686401953363 KILEVHIDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KILEVHIDK 9 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 10072300.0 4079600.0 2634900.0 3357800.0 False True 5587938.367044623 2518481.4055508953 2564756.7960617384 1.0 0.4506995675549805 0.45898086693074963 22.413884677750605 -10.121755071217882 5.15681337458046 1.0000160165031386 0.4548402172525291 0.9998269638968372 0.003380826316135883 6.26901023450115e-07 1.0676107141625762e-07 0.0032735677310157174 0.0010911570011095792 7.555181966531765e-11 10.121755071217882 -0.5451757992506095 KILEVHIDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KILEVHIDK 9 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 5488230.0 2404200.0 2091700.0 992330.0 False True 1999198.8241189288 2080431.5969300559 1199821.6149844828 1.0 1.0406326633604976 0.6001512208338051 20.93099052730286 -6.884336274012964 1.0552728275286314 1.0269794663220644 0.5662119612243576 0.9770200059849409 0.030130507973730784 0.12386036075454321 0.24963831880321782 0.02190074106190087 0.05359824665727152 1.3051599120774817e-07 6.884336274012964 -0.4607675050977068 KILEVHIDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KILEVHIDK 9 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 25412700.0 5751600.0 10922000.0 8739100.0 False True 7445559.58098575 10314181.098790392 7148673.470738266 1.0 1.3852795060737197 0.9601257491773132 22.82794884988109 -6.668128966614847 1.9443976986538967 1.2463235650541218 0.9618726332691604 0.2706189367305524 0.1637304773534916 0.46542702035653627 3.3907041609163726 0.06784058786639288 0.18167050007215235 2.1471927563770982e-07 6.668128966614847 -0.2844509317849614 KINLELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KINLELR 7 1 Q9BTT0;E9PPH5;Q5TB19;E9PLC4;Q9BTT0-2;E9PI45;Q5TB25 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 0 28129800.0 10278000.0 7794800.0 10057000.0 False True 13474557.53229359 6631846.2238924205 9016398.113556018 1.0 0.4921754356681701 0.6691424257863019 23.683734563798115 -10.040851438252668 5.660542365733246 1.0000015605091856 0.5806589307271005 0.8821682275461926 0.07224647118474253 1.4228200179048263e-06 2.410500505286307e-07 0.06995260549361944 0.02331744830999366 9.102245854271515e-11 10.040851438252668 -0.41934262978208514 KINLELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KINLELR 7 1 Q9BTT0;E9PPH5;Q5TB19;E9PLC4;Q9BTT0-2;E9PI45;Q5TB25 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 0 32629800.0 8900200.0 14916000.0 8813600.0 False True 13502254.09177671 12254123.260760065 7071588.096861896 1.0 0.9075612988369998 0.5237338927852581 23.68669693782602 -6.944017131170138 0.6210670654467015 1.0041979348907433 0.40672548408438325 0.9986441429955081 0.007593002536723622 0.08598082976063323 0.04661637108344966 0.0076393041278681436 0.032496558967575674 1.1375824118887492e-07 6.944017131170138 -0.59747245080636 KINLELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KINLELR 7 1 Q9BTT0;E9PPH5;Q5TB19;E9PLC4;Q9BTT0-2;E9PI45;Q5TB25 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 0 31131700.0 10278000.0 8239700.0 12614000.0 False True 14078054.35250629 7875642.808955842 9634832.993484668 1.0 0.5594269358360415 0.6843866881199672 23.746944625321007 -10.436101429033416 8.960956890539007 1.00000334601642 0.6219068119780085 0.9242805116892743 0.05101460524670044 3.4102335161321757e-06 2.1454912616435373e-07 0.04939511610631614 0.016464893044484702 3.6635200351883e-11 10.436101429033416 -0.3780965340384115 KINLELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KINLELR 7 1 Q9BTT0;E9PPH5;Q5TB19;E9PLC4;Q9BTT0-2;E9PI45;Q5TB25 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 0 28104900.0 8900200.0 10984000.0 8220700.0 False True 11521484.349170573 10372730.74428801 6724616.951505073 1.0 0.900294652141305 0.58365890606701 23.45782325991847 -6.950164326588395 0.5570355985777323 1.0042072223235936 0.4646905778699031 0.9992141224703339 0.0049757951048912735 0.08341980318659813 0.03568965025729988 0.0053530698621869115 0.026304391932105518 1.1215939898088781e-07 6.950164326588395 -0.5395166444536905 KINPENSK(ub)LSDLDSETR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KINPENSKLSDLDSETR 17 2 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 1 23573300.0 4403000.0 6798300.0 12372000.0 True False 5699770.296105472 6419968.628814013 10120422.947440097 1.0 1.1263556766841352 1.7755843519440002 22.442472348365225 -6.939199811291033 0.6669719009104432 0.9926022968692411 1.9466117469506987 0.9980571336038705 0.014976380001674424 0.08813367276362039 0.05628753432313385 0.01449143412169764 0.05607772264310717 1.1502710476040042e-07 6.939199811291033 0.9540094500814577 KIPGIYVLSLEIGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KIPGIYVLSLEIGK 14 1 A0A2C9F2P4;A0A286YFF7;P50897;Q5T0S4;A0A286YFE3;A0A286YFL8;E9PIA8;E9PK48 A0A2C9F2P4 PPT1 Palmitoyl-protein thioesterase 1 0 57225000.0 15659000.0 28014000.0 13552000.0 False True 23755847.826243352 23014682.825618997 10873441.259947402 1.0 0.9688007346214105 0.45771640479761744 24.501779360452606 -6.919386403123636 0.8292671218230534 1.0115282089461013 0.37645215342331945 0.994008686720426 0.0192431234451306 0.09853430389504676 0.1074958827214385 0.01652624056096022 0.0492171068314398 1.2039642652968284e-07 6.919386403123636 -0.6350760555227819 down KIPGIYVLSLEIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIPGIYVLSLEIGK 14 1 A0A2C9F2P4;A0A286YFF7;P50897;Q5T0S4;A0A286YFE3;A0A286YFL8;E9PIA8;E9PK48 A0A2C9F2P4 PPT1 Palmitoyl-protein thioesterase 1 0 42653400.0 15659000.0 17288000.0 9706400.0 False True 20270884.185036477 16325907.602626648 7939934.79607442 1.0 0.8053870494054757 0.39169158698738493 24.272905682545055 -6.958835034975713 0.4515531047310523 1.0131310639961484 0.16750484952600075 0.9997245198868732 0.0042100205857154415 0.0801199351373651 0.02268903533413091 0.005542405339905082 0.03421170587864243 1.0994233717049315e-07 6.958835034975713 -0.8456262144701476 down KISSIQSIVPALEIANAHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KISSIQSIVPALEIANAHR 19 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 27574300.0 9987600.0 9174900.0 8411800.0 False True 13093840.320055991 7806040.683480083 7541427.627683254 1.0 0.5961612859692108 0.5759523137098258 23.642384954630014 KISSIQSIVPALEIANAHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KISSIQSIVPALEIANAHR 19 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 66738000.0 4808000.0 43146000.0 18784000.0 False True 7294087.511883146 35446259.198763385 15071334.166680327 1.0 4.859587870452088 2.0662398335812253 22.79829607804707 -6.562572752625704 2.3348606239181957 3.6549972839120204 2.0707498692488326 0.0 1.6840229022697752 0.7531995105396264 7.697398526169728 0.6123034131647241 1.8938450588904816 2.7379609350620403e-07 6.562572752625704 -1.5842474146631877 KISSIQSIVPALEIANAHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KISSIQSIVPALEIANAHR 19 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 46116900.0 9987600.0 24085000.0 12044300.0 False True 13680285.624741374 23020845.061555773 9199684.400144864 1.0 1.6827751768516883 0.6724775090592294 23.705595016152905 -6.724684055413418 1.7424249396476343 1.413314801473154 0.6736266855428996 0.5344428976983708 0.2871642691293183 0.3463458877628745 2.057398019598005 0.13073339643454226 0.326400002155451 1.885019922611214e-07 6.724684055413418 -0.7396881159302544 KISSIQSIVPALEIANAHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KISSIQSIVPALEIANAHR 19 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 10015870.0 6182500.0 3112700.0 720670.0 False True 5141022.681189275 3095931.2672774214 871358.7649984044 1.0 0.6022014410878339 0.16949132867798058 22.293623946315567 -7.614813906826773 0.40388589536570657 1.0408946575692364 3.1417353640529682e-22 0.998497288090959 0.01314722920637694 0.12075320920905883 0.05807495531693593 0.02432962377930722 0.07238315884198368 2.4276501090693322e-08 7.614813906826773 -1.0408946575692364 down KISSIQSIVPALEIANAHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KISSIQSIVPALEIANAHR 19 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 49899300.0 4808000.0 22218300.0 22873000.0 False True 6224050.779849 20981832.073544636 18710348.696799044 1.0 3.3710894746353066 3.006136896790063 22.56942240013952 -10.374978871877643 10.937543221412962 0.9999996809221166 3.1886131857126845 0.9795716946882244 0.14899126600570067 1.1594637480172925e-06 6.642990121886069e-08 0.1442601944797042 0.0480867243308698 4.217170191671448e-11 10.374978871877643 2.1886135047905677 KITIADCGQLE ddPTM_RPMI8226_Bortezomib_1h_R1 1 KITIADCGQLE 11 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 263398000.0 57293000.0 114090000.0 92015000.0 False True 75111677.82620127 97068216.71933681 82494170.47020555 1.0 1.2923185785296945 1.0982868823818102 26.16253388929081 -10.433393883057878 3.774126683138837 0.9985821167868699 1.1953027304711694 0.5746235638501456 0.079213108309395 56959273.72837018 1301.8835894448753 702839.1456417685 0.02711671127195423 3.6864310631778854e-11 10.433393883057878 0.1967206136842995 KITIADCGQLE ddPTM_RPMI8226_Bortezomib_2h_R1 1 KITIADCGQLE 11 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 124252000.0 69204000.0 15295000.0 39753000.0 False True 67007156.900354385 21402373.262371328 29340496.735563193 1.0 0.31940428832398554 0.4378710885942397 25.997811859382267 -10.033826596830645 6.004422030560755 1.0000007964510012 0.3786376884671105 0.9734610729532432 0.04836386868732929 6.356349386613682e-07 1.0226796640862386e-07 0.04682818845322679 0.015609371498641748 9.25067457030777e-11 10.033826596830645 -0.6213631079838906 KITIADCGQLE ddPTM_RPMI8226_Bortezomib_8h_R1 1 KITIADCGQLE 11 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 777928000.0 19647000.0 723530000.0 34751000.0 False True 29805935.388096496 594410418.5343076 27882449.61809563 1.0 19.942686273543202 0.9354663510822396 24.829096313768986 -6.468103239447858 2.783250517662702 9.999999999999998 0.8822993765841127 0.2500634904776151 7.746197870424501 0.6306701108270868 9.106756427584523 2.991339458618971 10.669145370768623 3.4032727829589333e-07 6.468103239447858 -9.117700623415885 KITIADCGQLE ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KITIADCGQLE 11 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 341453000.0 57293000.0 155310000.0 128850000.0 False True 78475770.38510829 148447890.6585105 98418283.7490487 1.0 1.8916398007948738 1.2541231932617602 26.2257439508137 -10.041862234440135 5.9682863253108565 0.9999989044719753 1.57288149702836 0.5184613997531035 0.2602650651678674 3.7940572821681975e-06 6.090444523672829e-07 0.2520010463439261 0.0840001885828726 9.081085518950089e-11 10.041862234440135 0.5728825925563847 KITIADCGQLE ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KITIADCGQLE 11 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 107276000.0 69204000.0 11278000.0 26794000.0 False True 57546192.25701946 11217243.17549226 32396501.51854145 1.0 0.1949258975362351 0.5629651632526519 25.778217134816543 -10.664142656833219 6.527765241971759 1.0039877855988135 0.37894553043111107 0.7915246786494129 0.15025140105230259 0.008744515416696104 0.0004499095678919102 0.14588922442640612 0.04849343116832499 2.1669921753979443e-11 10.664142656833219 -0.6250422551677024 KITIADCGQLE ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KITIADCGQLE 11 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 93218000.0 19647000.0 73571000.0 0.0 False True 25433428.800268956 69476709.17589337 0.0 1.0 2.7317083245637197 0.0 24.600222635861435 -6.735434591379396 1.7035759691741443 2.0358063417018544 1.602236994626574e-05 0.5841468336115683 0.7277141895872516 0.3261716918334335 1.8568350151185633 0.3381968761195207 0.8340473438944264 1.8389308923948125e-07 6.735434591379396 -2.035790319331908 KIVDQIRPDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIVDQIRPDR 10 2 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 4959840.0 1177000.0 402440.0 3380400.0 False True 1139636.7792572274 563136.3906968755 2494971.830173766 1.0 0.4941367293041444 2.189269314210704 20.120142656642436 -6.826746490896467 1.3425784586794336 0.7290431377796279 2.231863792446554 0.8991694435864844 0.2256219034668461 0.18486346857911376 0.6528553439871193 0.13199568158346717 0.30380117215039776 1.4902307107055815e-07 6.826746490896467 1.5028206546669258 up KIVFVTGNAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KIVFVTGNAK 10 1 Q9BY32;Q9BY32-3 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 0 8427000.0 2676000.0 2179800.0 3571200.0 False True 3508261.914420867 1854582.3367938516 3201686.4813693184 1.0 0.5286328050851928 0.9126132995397646 21.742325027634422 -9.966437709607193 6.89982403327546 1.0000000206439426 0.7206230523124783 0.41377591225128096 0.1567593804325508 4.9698526496065377e-08 7.539267870799164e-09 0.15178162875286003 0.050593872481421394 1.0803445624346019e-10 9.966437709607193 -0.2793769683314643 KIVFVTGNAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KIVFVTGNAK 10 1 Q9BY32;Q9BY32-3 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 0 6237320.0 1516300.0 672620.0 4048400.0 False True 1468165.8864806578 941200.673666963 2988002.590603323 1.0 0.6410724308021597 2.03519412766487 20.48558355527235 -6.838367457042185 1.2897753043163553 0.8089827649590517 2.0796334043164717 0.9216283115567744 0.165463333437287 0.17072432638874582 0.5523555841781885 0.10061479262155837 0.23172859556490455 1.450883503967081e-07 6.838367457042185 1.27065063935742 up KIVFVTGNAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KIVFVTGNAK 10 1 Q9BY32;Q9BY32-3 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 0 11358700.0 2816000.0 6117900.0 2424800.0 False True 4272077.877176153 5026112.945629127 1945537.2171724073 1.0 1.1765031186536778 0.4554077133206217 22.026506515973182 -6.842000511058301 1.27318678734897 1.0938812118199768 0.4307525433639227 0.9278208090818656 0.08245349938513404 0.16647648077810123 0.523354884128942 0.05076562668201559 0.11701681465175655 1.4387968851430959e-07 6.842000511058301 -0.663128668456054 down KIVFVTGNAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KIVFVTGNAK 10 1 Q9BY32;Q9BY32-3 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 0 7240700.0 2676000.0 2303900.0 2260800.0 False True 3665389.516180858 2202106.080021521 1726845.602637555 1.0 0.6007836466766564 0.471121989904319 21.805535089157313 -13.999999999999998 0.1572668054299196 2.955156430711215 0.3397345485653676 0.9995438257702345 0.0048070379428243135 11.992568799531558 0.12522348540606223 7.154275222567196 0.11935049532730285 1.0000000000000041e-14 13.999999999999998 -2.615421882145847 KIVFVTGNAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KIVFVTGNAK 10 1 Q9BY32;Q9BY32-3 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 0 3379840.0 1516300.0 1101000.0 762540.0 False True 1260870.6334795486 1095068.6944686112 921983.5884133969 1.0 0.868502021850264 0.7312277436972692 20.265988830706625 -6.970584140343435 0.24383939160032433 1.0470029706251285 0.5487373812364621 0.9999865820504378 0.00040192083187788846 0.07611367791021399 0.008349472788023294 0.00319409849561154 0.01329313319772614 1.0700790453913896e-07 6.970584140343435 -0.4982655893886664 KIVFVTGNAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIVFVTGNAK 10 1 Q9BY32;Q9BY32-3 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 0 11677200.0 2816000.0 5061700.0 3799500.0 False True 3645367.51165865 4780011.945408102 3108029.9861621954 1.0 1.311256527667134 0.8525971596065592 21.79763283806563 -6.723999233909205 1.7454151980781505 1.1885572883710027 0.8531703816975661 0.5311061801334283 0.13091774893679045 0.3476011460781344 2.0717047280044785 0.05951423776074097 0.1486772147478716 1.8879946794956644e-07 6.723999233909205 -0.3353869066734366 KIYPTIWWLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KIYPTIWWLFR 11 1 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 21793500.0 4186900.0 6656900.0 10949700.0 False True 6351833.4033909235 5468924.184402911 8785486.995576 1.0 0.8609993110781728 1.3831419115756203 22.59874164313161 -6.835893615074695 1.3013670897063618 0.9259728541700378 1.3989617283218778 0.917153369585248 0.0635514742110264 0.1736509011567505 0.5730384749833541 0.0383169114452027 0.08819941823735757 1.459171655689169e-07 6.835893615074695 0.47298887415184 KIYPTIWWLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KIYPTIWWLFR 11 1 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 22086600.0 4186900.0 10404000.0 7495700.0 False True 5420024.586137645 9825008.254148984 6131559.512376884 1.0 1.812723927355903 1.1312789111804167 22.36986796522406 -10.223978270409427 4.5178062033858195 0.9998527595234213 1.4720014192732385 0.3901254139181485 0.27819876291604007 196027454.00988916 79.19109679727025 300253.34182010836 0.09523483619689543 5.970651595328068e-11 10.223978270409427 0.4721486597498171 KKPCITYGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KKPCITYGLR 10 2 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;J3QRH4;J3KRJ8 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 56746000.0 14422000.0 14457000.0 27867000.0 False True 18907381.662846666 12300071.952944623 24983590.15913946 1.0 0.6505433788917732 1.3213669985957206 24.172446253645685 -6.765143451218752 1.5931178484486648 0.7983198771838411 1.324460573707286 0.7116141886158796 0.1471114721251447 0.2743558129704358 1.3734209764358078 0.07282122649518953 0.17412328501407404 1.717341040883085e-07 6.765143451218752 0.526140696523445 KKPCITYGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KKPCITYGLR 10 2 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;J3QRH4;J3KRJ8 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 36997700.0 14795000.0 9363700.0 12839000.0 False True 22445096.6593825 7692674.576077969 10301366.022466388 1.0 0.3427329671517488 0.45895841656623965 24.419896973417167 -9.977745703721459 5.932784055423655 1.0000005160891152 0.4008456918618144 0.9725527073733327 0.04744884103231186 3.2388264006731827e-07 5.584945203804709e-08 0.04594218179791469 0.015314047592849496 1.0525780187084594e-10 9.977745703721459 -0.5991548242273008 KKPCITYGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KKPCITYGLR 10 2 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;J3QRH4;J3KRJ8 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 38659000.0 14422000.0 10374000.0 13863000.0 False True 19754203.139895465 9915642.377769552 10588844.917447116 1.0 0.501951018097206 0.5360299700503712 24.235656315168576 -10.237496884570763 7.1680576728928225 1.0000016462178172 0.5189904940737886 0.9962494533094904 0.013912673875679835 3.6601600692647856e-07 3.892536032589791e-08 0.013470934713797485 0.004490296185143581 5.7876614013681756e-11 10.237496884570763 -0.48101115214402856 KKPCITYGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KKPCITYGLR 10 2 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;J3QRH4;J3KRJ8 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 56349000.0 14795000.0 18105000.0 23449000.0 False True 19152419.15305031 17097440.83442594 19181522.607058115 1.0 0.8927039815595784 1.0015195706492863 24.191023295509616 -10.887205803023377 7.851862239355718 1.006881997109072 0.9471117761042728 0.2395285870499716 0.04442377822169143 0.005960417653830618 8.56229665157827e-05 0.047904174043854164 0.014337712769018554 1.296564710627405e-11 10.887205803023377 -0.05977022100479912 KKPFVYTQGQAVLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KKPFVYTQGQAVLNR 15 2 A6NKB8;Q9H4A4;A0A087WU27;A0A087WUS4;C9JMZ3 A6NKB8 RNPEP Aminopeptidase B 0 13246200.0 2738300.0 2990100.0 7517800.0 False True 3589937.8177349237 2543988.7353185113 6739930.171829714 1.0 0.7086442341008693 1.8774503944144312 21.77552742428548 -6.840697383434896 1.2790348682658963 0.8450093307895475 1.9164543918659798 0.9256609207800607 0.13544198922497477 0.16798934547899086 0.5335182455111739 0.08302159600704459 0.19131543997934 1.4431205682437203e-07 6.840697383434896 1.0714450610764321 KKPFVYTQGQAVLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKPFVYTQGQAVLNR 15 2 A6NKB8;Q9H4A4;A0A087WU27;A0A087WUS4;C9JMZ3 A6NKB8 RNPEP Aminopeptidase B 0 7373000.0 540810.0 613090.0 6219100.0 False True 523642.2825744275 857900.0342221139 4590131.140999189 1.0 1.6383322408655512 8.765776358685805 18.998222069805443 -6.924460588096809 0.7909451653167573 0.8665500336726031 10.04194197437844 0.9953328922943133 0.24047487656242342 0.09561767467172658 0.09253243751458785 0.21224945125799977 0.6656291439974102 1.1899793140032755e-07 6.924460588096809 9.175391940705838 up KKPFVYTQGQAVLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KKPFVYTQGQAVLNR 15 2 A6NKB8;Q9H4A4;A0A087WU27;A0A087WUS4;C9JMZ3 A6NKB8 RNPEP Aminopeptidase B 0 6412300.0 2738300.0 1708100.0 1965900.0 False True 3750723.509775052 1632630.4940686508 1501594.908981409 1.0 0.4352841497950264 0.40034806753096724 21.838737485808373 -13.967173805713832 0.395910867950323 9.999999991585616 0.39807507290389943 0.999831345233166 0.003568932600250099 25.456519755459688 0.2067344309462267 196.31294497316128 0.009045379846453136 1.078515011504367e-14 13.967173805713832 -9.601924918681716 KKPIVTINTNSISTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KKPIVTINTNSISTK 15 2 H7C1I7;Q5VZL5-3;Q5VZL5-2;Q5VZL5-4;Q5VZL5 H7C1I7 ZMYM4 Zinc finger MYM-type protein 4 0 7500300.0 2425200.0 1817000.0 3258100.0 False True 3179460.6856702096 1545910.6826105253 2920983.0659020417 1.0 0.48621789524806075 0.9187039421707199 21.60035063920649 -10.107728001649763 7.502089854033062 1.000000060205936 0.7024609187093913 0.3869082785400231 0.17656168930564967 1.7767976245143952e-07 2.1392457711215e-08 0.17095515368116238 0.05698504018825245 7.80318670588374e-11 10.107728001649763 -0.2975391414965447 KKPIVTINTNSISTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKPIVTINTNSISTK 15 2 H7C1I7;Q5VZL5-3;Q5VZL5-2;Q5VZL5-4;Q5VZL5 H7C1I7 ZMYM4 Zinc finger MYM-type protein 4 0 4345070.0 801640.0 603430.0 2940000.0 False True 776192.3769955505 844382.7458458785 2169925.801890564 1.0 1.0878524073043285 2.7956030826917067 19.566054738886223 -6.917567185725099 0.842568578197663 0.9589152793288654 3.0561554455716275 0.9934781027798076 0.06674887958439325 0.0996245737015216 0.1131862626907487 0.056782038993039595 0.16632820045362812 1.2090181323435167e-07 6.917567185725099 2.097240166242762 up KKPIVTINTNSISTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KKPIVTINTNSISTK 15 2 H7C1I7;Q5VZL5-3;Q5VZL5-2;Q5VZL5-4;Q5VZL5 H7C1I7 ZMYM4 Zinc finger MYM-type protein 4 0 5593500.0 2425200.0 1907000.0 1261300.0 False True 3321861.978565699 1822742.4343943058 963406.9172889016 1.0 0.5487110681164793 0.29002015240406764 21.66356070072938 -8.940871283280789 0.19345439472760612 1.3989880006153492 5.7010010381495216e-18 0.9996415963272793 0.0055541632561441215 0.4224238289859803 0.06163185752540574 0.24574474394606108 0.14094214235403052 1.1458525002613871e-09 8.940871283280789 -1.3989880006153492 down KKPNATRPVTPPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KKPNATRPVTPPR 13 3 P36873;P36873-2;F8W0W8 P36873 PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase 0 9987560.0 587660.0 4599500.0 4800400.0 False True 770427.9509075359 3913272.528710579 4303700.656688308 1.0 5.079349112530104 5.586116977737771 19.555300519134537 -9.781723434125594 0.5376291832674541 1.400332346678685e-16 5.557314211222701 0.9990641922280967 0.06280086376572604 1.0631732740575757 0.24376567312599193 2.0318633834717965 0.0959321409357724 1.6530141297282688e-10 9.781723434125594 5.557314211222701 KKPNATRPVTPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKPNATRPVTPPR 13 3 P36873;P36873-2;F8W0W8 P36873 PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase 0 3573770.0 1257500.0 572370.0 1743900.0 False True 1217581.3508206997 800920.3258701193 1287120.2741214135 1.0 0.6577961508118255 1.0571123426404665 20.21558673629688 -6.679867784241321 1.9025435606554513 0.783452125483337 1.0555828116921073 0.3233915051153351 0.145039350826213 0.43884351491166274 3.0710891197737937 0.06117639869784297 0.16136495924836108 2.0899322888930717e-07 6.679867784241321 0.27213068620877034 KKPNATRPVTPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KKPNATRPVTPPR 13 3 P36873;P36873-2;F8W0W8 P36873 PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase 0 10157960.0 587660.0 4298800.0 5271500.0 False True 804933.7829143656 4108864.801769403 4026480.269950406 1.0 5.104599768309801 5.002250316009871 19.61851058065743 -10.228892998854247 4.351601401089631 0.9982125917853045 5.053425042258412 0.9995220522600338 0.04178398926240569 7364111.1099314215 418.65398257398397 131902.47075466302 0.014303770864511905 5.903465113821594e-11 10.228892998854247 4.055212450473107 KKPNATRPVTPPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KKPNATRPVTPPR 13 3 P36873;P36873-2;F8W0W8 P36873 PPP1CC Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase 0 2852770.0 1257500.0 710480.0 884790.0 False True 1045666.966695596 706652.5032207624 1069795.4981932635 1.0 0.6757911703511582 1.0230747764500163 19.995992011731158 -10.123868071479984 12.982172779652714 0.999999655937147 0.8494329734005895 0.20040184014800555 0.14177793849612358 0.0 0.0 0.13727589866371362 0.04575863288790453 7.518512541816354e-11 10.123868071479984 -0.15056668253655747 KKPRPPPALGPEETSASAGLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KKPRPPPALGPEETSASAGLPK 22 3 Q01105 Q01105 SET Protein SET 0 7650200.0 1069700.0 3307800.0 3272700.0 False True 1402387.0589895358 2814289.1337034134 2934072.3979551294 1.0 2.006784871311632 2.09219871158054 20.419453157629412 -10.914515436786473 0.4496434511691257 2.41033346972855e-10 2.0931858460257735 0.9996388952327678 0.0094246532606725 2.6320331048243237 0.2179188975707433 2.785234497634165 0.01925473004071332 1.2175437150759826e-11 10.914515436786473 2.09318584578474 KKVEAQLQELQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KKVEAQLQELQVK 13 2 P35579 P35579 MYH9 Myosin-9 0 7451100.0 1419600.0 3370700.0 2660800.0 False True 1861109.3474259546 2867804.6988856895 2385485.9401958683 1.0 1.5409114477083603 1.2817548541654273 20.82773139116654 -10.035484904313126 4.382946803699172 0.999976399465409 1.411333150780549 0.7705861771278136 0.10580023647850535 24391894.46126145 0.47493556043923274 5997.913964079558 0.036218235037948514 9.215419201493042e-11 10.035484904313126 0.41135675131514016 KKVEAQLQELQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKVEAQLQELQVK 13 2 P35579 P35579 MYH9 Myosin-9 0 5764340.0 1337300.0 789440.0 3637600.0 False True 1294848.1435010103 1104667.5088752136 2684803.4343391573 1.0 0.8531251439944252 2.0734504256846567 20.30435148154933 -6.876833535903087 1.0973504413161639 0.9122846965779519 2.154835157416827 0.9710382847061982 0.09257239708694978 0.1304698035922699 0.2895750412970023 0.06516066821185171 0.15637748107221539 1.3279033425571632e-07 6.876833535903087 1.242550460838875 up KKVEAQLQELQVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KKVEAQLQELQVK 13 2 P35579 P35579 MYH9 Myosin-9 0 37499700.0 1957800.0 32198000.0 3343900.0 False True 2970125.7343520853 26452015.33587776 2682976.699316562 1.0 8.906025435198657 0.9033209161099158 21.502092575261543 -6.649032161897959 2.0129080840124143 6.134345527194262 0.9375254626437255 0.18986353086630736 3.3752224882427333 0.5108441357287674 3.9666255987578913 1.360718483853564 3.736229544780541 2.2437157581225114e-07 6.649032161897959 -5.196820064550536 KKVEAQLQELQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KKVEAQLQELQVK 13 2 P35579 P35579 MYH9 Myosin-9 0 7638800.0 1419600.0 2889400.0 3329800.0 False True 1944464.4832475102 2761736.7540319394 2543369.819383638 1.0 1.4203071219997176 1.3080052843834296 20.890941452689432 -10.275795156120077 5.160206410824814 0.999933287787907 1.3641562031915717 0.9334210185050386 0.04584703322306839 3.519665635248477e-05 4.939508627965563e-06 0.04439930307497618 0.014797066345458255 5.2991332942134066e-11 10.275795156120077 0.3642229154036647 KKVEAQLQELQVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KKVEAQLQELQVK 13 2 P35579 P35579 MYH9 Myosin-9 0 7903800.0 1957800.0 3816000.0 2130000.0 False True 2534410.6940075657 3603636.2454664055 1742361.855645603 1.0 1.421883301702817 0.6874820484956499 21.273218897353992 -6.750904558806837 1.6463494293759457 1.2478000191940863 0.6859079223077711 0.6529111833970802 0.17728719871221987 0.29847168163555365 1.5919503242469186 0.08505413091214138 0.20630467474987493 1.7745794222215946e-07 6.750904558806837 -0.5618920968863153 KKVPVSVNLLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KKVPVSVNLLSK 12 2 O76021;J3QSV6;I3L3C4 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 32297800.0 8221800.0 10011000.0 14065000.0 False True 10778859.42002445 8517397.82257237 12609688.721006803 1.0 0.7901947219711535 1.169853713611027 23.361701189599515 -6.756709359187931 1.625040933535716 0.8776347690695907 1.171010827558329 0.6773182195803151 0.08820746249741855 0.288481454787822 1.5006940531541177 0.042845186576560626 0.10329353259813885 1.75101812205974e-07 6.756709359187931 0.2933760584887384 KKVPVSVNLLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KKVPVSVNLLSK 12 2 O76021;J3QSV6;I3L3C4 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 24177600.0 10846000.0 2367600.0 10964000.0 False True 10501699.66680025 3312995.026870894 8092199.4870503945 1.0 0.3154722694407739 0.7705609324015259 23.3241195066192 -10.557633934763397 5.6156478163635475 1.0014987472366712 0.543016600921708 0.5734623567995862 0.18578916866321296 0.00349629923140467 0.00027541646377529156 0.18041149406851323 0.05996319634486197 2.769274873640737e-11 10.557633934763397 -0.4584821463149632 KKVPVSVNLLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KKVPVSVNLLSK 12 2 O76021;J3QSV6;I3L3C4 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 24795200.0 7361700.0 10772000.0 6661500.0 False True 11168237.112360684 8849652.437979847 5344851.605160829 1.0 0.7923947485127537 0.4785761218523289 23.412898140993114 -6.965128783211543 0.35583589045805375 1.0283612453426627 0.23192462972460545 0.99991577410385 0.0019670664682538822 0.07791729518214742 0.014706049470169113 0.004247931251190693 0.02687240268131389 1.0836055401606564e-07 6.965128783211543 -0.7964366156180572 down KKVPVSVNLLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KKVPVSVNLLSK 12 2 O76021;J3QSV6;I3L3C4 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 29392800.0 8221800.0 10294000.0 10877000.0 False True 11261621.64579063 9839177.042294184 8308076.618846737 1.0 0.8736909613698373 0.7377335946952304 23.424911251122406 -6.970186926291779 0.25368312514547386 1.041237886700592 0.5661858799907654 0.9999838009229239 0.000430993927038466 0.07624209466512197 0.008812924812121117 0.002958233268551085 0.01295325684456945 1.0710582078948065e-07 6.970186926291779 -0.4750520067098266 KKVPVSVNLLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KKVPVSVNLLSK 12 2 O76021;J3QSV6;I3L3C4 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 19719500.0 10846000.0 5533000.0 3340500.0 False True 9018929.55926874 5503192.63078549 4038983.1052731057 1.0 0.6101824606369021 0.44783397838186345 23.104524782053478 -13.999999999999995 0.12013501231137134 2.8577453902763033 0.18918679351393872 0.999692279432741 0.0040646294326653456 11.963233406896542 0.10668835184000137 5.305161719272818 0.22952201271204012 1.0000000000000123e-14 13.999999999999995 -2.6685585967623644 KKVPVSVNLLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KKVPVSVNLLSK 12 2 O76021;J3QSV6;I3L3C4 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 24354000.0 7361700.0 9334200.0 7658100.0 False True 9529865.770801665 8814743.56457875 6264404.378741605 1.0 0.924959886799879 0.657344450530979 23.184024463085564 -6.947514079412402 0.5855073158408012 1.0031372732362678 0.5658047316848378 0.9989914156676176 0.004670624611596171 0.08449976715534731 0.040215149034246105 0.00486491761001337 0.022389931281572125 1.1284593533600661e-07 6.947514079412402 -0.43733254155143 KLADQCTGLQGFLVFHSFGGGTGSGFTSLLMER ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLADQCTGLQGFLVFHSFGGGTGSGFTSLLMER 33 1 P68363;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 182279000.0 38919000.0 45124000.0 98236000.0 False True 59042968.36002085 37071269.6445788 78819611.54163164 1.0 0.627869341164095 1.3349534031050163 25.815261918310235 -6.763692170017822 1.598408203523655 0.7848416336280492 1.3380337637095687 0.7059159294147159 0.15661421587882554 0.2767598369495066 1.3943599903841257 0.0772761522753433 0.1850483378780655 1.7230894762123583e-07 6.763692170017822 0.5531921300815196 KLADQCTGLQGFLVFHSFGGGTGSGFTSLLMER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLADQCTGLQGFLVFHSFGGGTGSGFTSLLMER 33 1 P68363;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 104864400.0 38919000.0 7367400.0 58578000.0 False True 50381412.70818289 6957397.713534914 47917405.0610367 1.0 0.13809453406622918 0.9510929226733257 25.586388240402684 -8.980722100507974 11.747771581937812 1.0000084665653184 0.5445937283696259 0.2949638372049016 0.33190520233527787 0.0 0.0 0.3213658302745164 0.10712194342483876 1.045388936274523e-09 8.980722100507974 -0.45541473819569245 KLAK(ub)EYHPDKNPNAGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLAKEYHPDKNPNAGDK 17 3 O60884;I3L320 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 6577200.0 1189200.0 1241300.0 4146700.0 True False 1151449.4969351694 1736957.5632939872 3060554.871666537 1.0 1.508496523657593 2.658001831441902 20.135019704624273 -6.957581304687289 0.4682849764839029 0.9691268485155402 3.244359150272126 0.9996696831303167 0.012604711671744298 0.0805768229658171 0.024412215745548846 0.015843039299159156 0.09488703909531233 1.1026017953847327e-07 6.957581304687289 2.275232301756586 KLALK(ub)YHPDKNPNEGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLALKYHPDKNPNEGEK 17 3 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 47084200.0 5985200.0 20999000.0 20100000.0 True False 9079985.976731064 17251564.384064134 16127226.189857038 1.0 1.8999549589915739 1.7761289754395733 23.114258638721843 -10.27556283097186 5.410119712057166 0.9998990807627868 1.8380419672156212 0.98388984260778 0.050551746100277815 6.154185805292658e-05 8.240590146655311e-06 0.04895233291305377 0.01631550589731594 5.301968815573711e-11 10.27556283097186 0.8381428864528344 KLALK(ub)YHPDKNPNEGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLALKYHPDKNPNEGEK 17 3 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 48970200.0 5985200.0 20257000.0 22728000.0 True False 7747959.385930157 19129680.142665897 18591737.208973404 1.0 2.4689959239337624 2.399565651148729 22.885384960814292 -10.37166042029522 6.047239524534635 0.9997725351832308 2.4342807875412467 0.9982456022240241 0.02834479017093225 8.693829078221039e-05 9.03324450178297e-06 0.027448799192873952 0.009148241690313287 4.249517085615811e-11 10.37166042029522 1.434508252358016 KLALVFNIPLHQINQVYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLALVFNIPLHQINQVYR 18 1 Q9NZI7;Q9NZI7-4 Q9NZI7 UBP1 Upstream-binding protein 1 0 60653900.0 13530900.0 17573000.0 29550000.0 False True 20527364.541293606 14436960.851524333 23709429.547774892 1.0 0.7033031845116994 1.1550157595769357 24.29104507941884 -6.729523585308979 1.7248608398080902 0.8213520750811203 1.1547276825282602 0.5570522007722523 0.12472956901457596 0.33715755762284966 1.9649136605164481 0.05730869799975352 0.14229019008491556 1.864130939807424e-07 6.729523585308979 0.3333756074471399 KLALVFNIPLHQINQVYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLALVFNIPLHQINQVYR 18 1 Q9NZI7;Q9NZI7-4 Q9NZI7 UBP1 Upstream-binding protein 1 0 62694700.0 13530900.0 25082300.0 24081500.0 False True 17516016.783914067 23686447.955886275 19698914.097056147 1.0 1.352273650344915 1.124622928835439 24.06217140151129 -10.212565567917823 5.20169372189779 0.9999808845267322 1.2384482895902578 0.5939603978190219 0.09293801787941007 2.0605171423533287e-05 3.1194172542067716e-06 0.089994058741532 0.029995616289663487 6.129632426027775e-11 10.212565567917823 0.2384674050635256 KLCLNICVGESGDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLCLNICVGESGDR 14 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 986500000.0 241180000.0 375440000.0 369880000.0 False True 365887692.6197954 308439798.67389107 296773055.8758372 1.0 0.8429903626039695 0.8111042318775745 28.446825647596313 -13.99999999999911 0.2240932501536532 1.964824589248303 0.7947031312123117 0.9995023169239031 0.0018418812067664018 13.114215767457654 0.1499327015674565 5.611517020389961 0.01718214373544789 1.0000000000020491e-14 13.99999999999911 -1.1701214580359913 KLCLNICVGESGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLCLNICVGESGDR 14 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 37402700.0 5564700.0 11761000.0 20077000.0 False True 7622119.970363086 11241360.131573914 15335226.098794335 1.0 1.474833796277602 2.011937119649381 22.861760885331215 -6.969523345501368 0.2693261323895906 0.8653845609428176 2.637518794067813 0.9999784229422761 0.0019201977541685954 0.07645766977833707 0.009582175916685223 0.010572044161343441 0.05000005544340269 1.0726959835093895e-07 6.969523345501368 1.7721342331249952 KLCLNICVGESGDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLCLNICVGESGDR 14 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 788579300.0 241180000.0 297569300.0 249830000.0 False True 312212264.3685485 281009306.8705628 204363503.47227293 1.0 0.9000585144818256 0.6545659053003556 28.217951969688762 -6.955837997685413 0.4905872828753964 1.0053439357744234 0.5388601354338322 0.9995833392839643 0.0029625455793258967 0.08122277023868399 0.026890432885625138 0.003539054977304654 0.02024750192426776 1.1070366583361363e-07 6.955837997685413 -0.4664838003405912 KLDDTK(ub)FR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLDDTKFR 8 2 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 5010330.0 2136700.0 1989200.0 884430.0 True False 2801234.391832231 1692419.113840871 792917.6676516208 1.0 0.6041690473227033 0.28306009306596774 21.41763127454526 -7.776782085694527 0.26258874760133627 1.1417016993184514 9.451884611013172e-12 0.9996717312857503 0.005312591921967284 0.12290922974816643 0.0386242564638276 0.04491352056504887 0.08367378335047065 1.6719293215503542e-08 7.776782085694527 -1.1417016993089995 down KLDDTK(ub)FR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLDDTKFR 8 2 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 5958400.0 2167100.0 2492000.0 1299300.0 True False 2098306.5967105636 3487068.595608319 958974.3518355136 1.0 1.6618489409864439 0.4570229886036967 21.000794063844136 -6.757550724701268 1.621573643513951 1.3856063589136591 0.4531285025976415 0.680932463144557 0.27828734562286 0.2870526182480984 1.4870507587567874 0.13544011431667968 0.3262910556231783 1.7476291310132766e-07 6.757550724701268 -0.9324778563160177 KLDDTK(ub)FR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLDDTKFR 8 2 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 8319500.0 3000200.0 3015800.0 2303500.0 True False 4551522.743999956 2477606.927447055 1848212.2153400825 1.0 0.5443468190317536 0.4060645896533172 22.117917859182672 -13.999999999999998 0.16705719117587314 3.280710091084398 0.2801823260600268 0.9995196043488107 0.0055616693441992325 12.06425880241828 0.12936740887568282 8.914667342600167 0.11583375541544934 1.0000000000000041e-14 13.999999999999998 -3.000527765024371 KLDDTK(ub)FR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLDDTKFR 8 2 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 7551690.0 2167100.0 4467500.0 917090.0 True False 1802039.6688079701 4443432.690770678 1108849.278854936 1.0 2.465779620550729 0.6153301162279229 20.781199339278412 -6.695599335191477 1.8464461043528573 1.91409753809916 0.6212577393722695 0.39672770912701016 0.6192384320689934 0.4047751404562917 2.679740416362528 0.26786045627000404 0.6926631795583568 2.0155828982331812e-07 6.695599335191477 -1.2928397987268907 KLDDTK(ub)FR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLDDTKFR 8 2 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 1 11058300.0 3000200.0 4761900.0 3296200.0 True False 3883818.0427834755 4496896.078953479 2696325.421868093 1.0 1.1578544693434247 0.6942460723354784 21.88904418127512 -6.814849142414653 1.3942782116852903 1.0855494416186755 0.6852220702581078 0.8720553400863619 0.06883845183254149 0.20026634427589415 0.7663744766718324 0.03881325962238955 0.08959276083878978 1.5316193963206572e-07 6.814849142414653 -0.40032737136056773 KLDEAVAEAHLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLDEAVAEAHLGK 13 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 21514700.0 3571600.0 8585900.0 9357200.0 False True 4682402.187423597 7304917.187576067 8389006.704600412 1.0 1.5600789712588654 1.7916031918685533 22.158817427072197 -10.920343487879997 0.17313929963324712 2.5465849682831487e-16 2.034412173184661 0.9995213833668972 0.007270258662143052 3.0041251849799786 0.09738967412662582 1.3864980303577186 0.17676084742101805 1.2013139274991157e-11 10.920343487879997 2.0344121731846605 KLDEAVAEAHLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLDEAVAEAHLGK 13 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 14377800.0 2525700.0 2055200.0 9796900.0 False True 2445523.035998279 2875852.077726416 7230797.989299887 1.0 1.1759660552747455 2.9567490810194825 21.22171162376228 -6.926001694111608 0.778910904848833 0.9685333244605996 3.287702006140217 0.9956924265268259 0.058010182546299846 0.09476757892826078 0.08824466660676211 0.05164320963318661 0.16481400923947473 1.1857641226866028e-07 6.926001694111608 2.3191686816796175 up KLDEAVAEAHLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLDEAVAEAHLGK 13 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 19013100.0 3571600.0 6952800.0 8488700.0 False True 4892117.03886081 6645602.306165046 6483843.890264245 1.0 1.3584307679835388 1.3253656522849846 22.22202748859509 -10.09146924254515 4.6737628122493975 0.9999813002248766 1.3418982100776378 0.9930341842556357 0.013498776987285363 2.7279058172110836e-06 5.302397421833628e-07 0.013070875314665203 0.004356711534619669 8.100853112329049e-11 10.09146924254515 0.34191690985276113 KLDEAVAEAHLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLDEAVAEAHLGK 13 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 5779100.0 2525700.0 1777000.0 1476400.0 False True 2100231.4574815608 1767426.9482931164 1785108.413897684 1.0 0.8415391275076327 0.8499579451296533 21.002116899196555 -9.811397389145451 5.787548383680086 1.0000000203767165 0.8457485363186955 0.9977708621711545 0.003436967903985197 9.021706538497377e-10 1.8849914771512393e-10 0.0033278303087873697 0.001109276620830268 1.54384114392952e-10 9.811397389145451 -0.15425148405802103 KLDIK(ub)NEDDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLDIKNEDDVK 11 2 Q07820;A0A087WT64 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 7583700.0 1867800.0 2153600.0 3562300.0 True False 1808507.7113820312 3013543.710875636 2629226.763290736 1.0 1.6663151016219535 1.4538100925660555 20.786368318906966 -10.056118324232626 4.5670646418278364 0.9999741349118116 1.5600625968840058 0.9025467805852206 0.08675480675955763 30063235.181088243 0.5151817322184351 8656.757346389888 0.029698477881774737 8.78783058349175e-11 10.056118324232626 0.5600884619721942 KLDIK(ub)NEDDVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLDIKNEDDVK 11 2 Q07820;A0A087WT64 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 5539900.0 1877600.0 1952900.0 1709400.0 True False 2571799.460232126 1866614.4206233043 1305674.9261980886 1.0 0.7258009224618264 0.5076892449772272 21.29434672015166 -7.0981447863965235 0.15217424247566644 1.254797632301235 1.9152021395301682e-11 0.9999981106690831 0.0002767965730852578 0.07641998119517293 0.005247066957137934 0.012805031766017813 0.029100757552455465 7.977286937478275e-08 7.0981447863965235 -1.254797632282083 KLDIK(ub)NEDDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLDIKNEDDVK 11 2 Q07820;A0A087WT64 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 6839100.0 1867800.0 3083200.0 1888100.0 True False 1553158.4575698094 3066590.1896327147 2282892.980411959 1.0 1.9744219752252044 1.4698390684386111 20.566773594341242 -10.214980067139445 4.825742905122046 0.9998824259927203 1.7221305218336591 0.7319678294152879 0.20599510909894858 0.000260617595271347 4.239574264929898e-05 0.19948603295610737 0.06648463557750885 6.095648738627309e-11 10.214980067139445 0.7222480958409389 KLDIK(ub)NEDDVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLDIKNEDDVK 11 2 Q07820;A0A087WT64 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 13055300.0 4586900.0 5859600.0 2608800.0 True False 5937832.471316426 5533508.108997635 2134025.1685484783 1.0 0.9319070781683485 0.35939464086553485 22.5015049593462 -6.9291830256831295 0.753471820425802 1.008975329472685 0.24427073442985034 0.9963751452095206 0.01729636412650712 0.09306437781697542 0.07977581732922859 0.0156818816666095 0.05203722816675465 1.1771097969930666e-07 6.9291830256831295 -0.7647045950428347 down KLDIKNEDDVK(ub)SLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLDIKNEDDVKSLSR 15 3 Q07820;A0A087WT64 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 14921200.0 5468900.0 7029600.0 2422700.0 True False 7079598.858135642 6638396.580484966 1981793.4590012217 1.0 0.9376797631487749 0.2799301907796386 22.755236186444048 -6.925331724120803 0.7841733156645331 1.0119198606366409 0.1596654890804896 0.99553824188176 0.021758938834443787 0.09513555355545776 0.09009659665741572 0.019298028360077685 0.0611137995113769 1.187594768694728e-07 6.925331724120803 -0.8522543715561512 down KLDLFANVVHVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLDLFANVVHVK 12 1 A0A087X2E5;A0A087WZN1;O43837-2;O43837 A0A087X2E5 IDH3B Isocitrate dehydrogenase [NAD] subunit, mitochondrial;Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0 14573800.0 5184200.0 4810000.0 4579600.0 False True 6796536.403864215 4092366.749233148 4105746.922625153 1.0 0.602125333560548 0.604094008867635 22.69636828833483 -9.883644548843348 5.615749249420154 1.0000001977127557 0.6031096712150943 0.999981546327043 0.000803708332929429 2.1482059327532846e-09 4.274322879266958e-10 0.0007781876627165238 0.00025939574842345477 1.3072403698329722e-10 9.883644548843348 -0.39689052649766143 KLDLFANVVHVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLDLFANVVHVK 12 1 A0A087X2E5;A0A087WZN1;O43837-2;O43837 A0A087X2E5 IDH3B Isocitrate dehydrogenase [NAD] subunit, mitochondrial;Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0 15682700.0 4787600.0 2096900.0 8798200.0 False True 4635620.258599749 2934203.1051890436 6493687.479657683 1.0 0.6329688243435537 1.4008238633462156 22.14433095761122 -6.7767521791813445 1.5487952267663052 0.7912989186544312 1.4062695854373801 0.7556359825390015 0.15501095333370604 0.2556546955273987 1.211095340007324 0.07885222541429249 0.1865487335539851 1.6720444583988051e-07 6.7767521791813445 0.6149706667829489 KLDLFANVVHVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLDLFANVVHVK 12 1 A0A087X2E5;A0A087WZN1;O43837-2;O43837 A0A087X2E5 IDH3B Isocitrate dehydrogenase [NAD] subunit, mitochondrial;Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0 14170000.0 2053900.0 6989600.0 5126500.0 False True 3115916.460203158 5742251.27000594 4113245.027975227 1.0 1.8428771577629346 1.3200755156661175 21.571225123626757 -10.21083462011872 4.36415575389481 0.9998054480911218 1.5814763367318372 0.6225576465924703 0.21343287685773962 150198068.2321586 119.98497765377802 315690.1346920552 0.07306375069560019 6.154111774404835e-11 10.21083462011872 0.5816708886407154 KLDLFANVVHVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLDLFANVVHVK 12 1 A0A087X2E5;A0A087WZN1;O43837-2;O43837 A0A087X2E5 IDH3B Isocitrate dehydrogenase [NAD] subunit, mitochondrial;Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0 18650200.0 5184200.0 3765900.0 9700100.0 False True 7100938.837737214 3599510.085834046 7409136.159830389 1.0 0.506906222977843 1.0434023344146117 22.759578349857723 -6.665044502598554 1.9548675494698975 0.6839282415808223 1.0411958806550974 0.257283541513183 0.20969791117595732 0.4726186995862419 3.4770369808352437 0.08650503960740064 0.23262975781565665 2.1624969191080766e-07 6.665044502598554 0.35726763907427506 KLDLFANVVHVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLDLFANVVHVK 12 1 A0A087X2E5;A0A087WZN1;O43837-2;O43837 A0A087X2E5 IDH3B Isocitrate dehydrogenase [NAD] subunit, mitochondrial;Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0 9856400.0 4787600.0 2782400.0 2286400.0 False True 3981101.52664162 2767410.6589368423 2764475.6688808366 1.0 0.6951369213814993 0.6943996907340604 21.924736233045497 KLDLWSLPPVLVVHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLDLWSLPPVLVVHLK 16 1 Q9Y4E8-2;Q9Y4E8-3;Q9Y4E8;H0YI26;H0YH96 Q9Y4E8-2 USP15 Ubiquitin carboxyl-terminal hydrolase 15 0 178453800.0 33988100.0 69436800.0 75028900.0 False True 51562432.562944084 57045260.52780542 60199405.0286649 1.0 1.1063337723286861 1.167505139622289 25.619816991598302 -13.999999669725502 0.0623007368432869 0.33956786906255315 1.4295961708977942 0.9999480889780173 0.0004985999257660979 12.440296958964424 0.06470071111493464 1.2592058339806886 0.24462603488003398 1.0000007604854238e-14 13.999999669725502 1.090028301835241 KLDLWSLPPVLVVHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLDLWSLPPVLVVHLK 16 1 Q9Y4E8-2;Q9Y4E8-3;Q9Y4E8;H0YI26;H0YH96 Q9Y4E8-2 USP15 Ubiquitin carboxyl-terminal hydrolase 15 0 14513600.0 7716000.0 3331900.0 3465700.0 False True 6416195.876758031 3313950.393369631 4190361.8464137134 1.0 0.5164976969256899 0.6530913218520715 22.613286755087373 -10.510950569612584 9.367332030072609 1.00001089368202 0.5847945093888923 0.9249238598920931 0.05576411386445739 1.2686977929722002e-05 6.624215212681125e-07 0.053994784950005155 0.01799779035942148 3.0835388914991845e-11 10.510950569612584 -0.4152163842931277 KLDLWSLPPVLVVHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLDLWSLPPVLVVHLK 16 1 Q9Y4E8-2;Q9Y4E8-3;Q9Y4E8;H0YI26;H0YH96 Q9Y4E8-2 USP15 Ubiquitin carboxyl-terminal hydrolase 15 0 115968500.0 33988100.0 50929100.0 31051300.0 False True 43998265.45561262 48094850.81472312 25400282.013243362 1.0 1.0931078831560601 0.5773018947501074 25.39094331369075 -6.860195527693941 1.1848323648396086 1.050537826977353 0.5522404835150562 0.9538734087737069 0.04820526809576181 0.14659477873439214 0.3909491945685661 0.031731526464227326 0.07408300913862204 1.379762929047076e-07 6.860195527693941 -0.4982973434622969 KLDNTK(ub)FR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLDNTKFR 8 2 J3KTL2;Q07955;Q07955-3;Q07955-2;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 1 11923600.0 4652500.0 5756500.0 1514600.0 True False 6099472.554874092 4897652.638661248 1357883.7210691 1.0 0.8029633045479532 0.22262313812429804 22.540253061939474 -6.968354773577085 0.5443524838203578 1.0080411342678193 2.319341645704785e-18 0.9993432972405691 0.00845592740703244 0.07995169123488759 0.03307616758441353 0.009335678875686053 0.046284339425647726 1.075586212201347e-07 6.968354773577085 -1.0080411342678193 down KLDNTK(ub)FR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLDNTKFR 8 2 J3KTL2;Q07955;Q07955-3;Q07955-2;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 1 14025280.0 6888500.0 6421700.0 715080.0 True False 5728092.962292338 6387105.027492357 864599.9218436439 1.0 1.1150491218522907 0.15094027410784858 22.449623475884067 -6.877104498604584 1.0957745557780876 1.0689150694670562 0.0862856502751424 0.9712759282521426 0.0728671898748053 0.13022804094810933 0.28802232242077985 0.05134996187144135 0.12331829020810323 1.3270751025742128e-07 6.877104498604584 -0.9826294191919138 down KLDPELHLDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLDPELHLDIK 11 1 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 78224000.0 20630000.0 31825000.0 25769000.0 False True 27046129.781204168 27076834.05287841 23102671.0737024 1.0 1.0011352556510906 0.8541950830154525 24.688918827766805 -6.905159856833482 0.9280857448674638 1.0052748197563681 0.837048504275974 0.9889627747293642 0.00724924838116648 0.10770579181495535 0.15678033584104564 0.005796535159952974 0.015511777772687772 1.2440566101992684e-07 6.905159856833482 -0.16822631548039413 KLDPELHLDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLDPELHLDIK 11 1 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 51349000.0 12980000.0 16769000.0 21600000.0 False True 12567957.004892796 23464949.149179768 15942312.013889858 1.0 1.867045625637062 1.2684887454407587 23.583246814490494 -10.054533880407979 5.955209270894267 0.9999986704102465 1.5677671855389483 0.5453901558810073 0.24435982308565896 4.3137143226611575e-06 6.85565778618181e-07 0.23660093829195333 0.07886679377439258 8.819949927986192e-11 10.054533880407979 0.5677685151287019 KLDPELHLDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLDPELHLDIK 11 1 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 138812000.0 32326000.0 73257000.0 33229000.0 False True 49040905.347157754 60183715.99044657 26661273.585211895 1.0 1.2272146193959816 0.5436537803794255 25.547482277167603 -6.817105992847964 1.3844024669883317 1.1228357208940096 0.5296427196123132 0.877589780386196 0.09944769979665449 0.1972659538141726 0.7436713491806768 0.05646120760016428 0.13024173315247872 1.523680842599275e-07 6.817105992847964 -0.5931930012816964 KLDPELHLDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLDPELHLDIK 11 1 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 69881000.0 20630000.0 22391000.0 26860000.0 False True 28257468.504787356 21401691.582864646 20516221.199064355 1.0 0.75738177251224 0.7260459724333945 24.752128889289697 -13.999999999999998 0.2885407557737286 3.0735421913232455 0.7173806175089061 0.9996241956715245 0.002373331713387261 15.879473036245537 0.1703121689651064 19.528244437708604 0.011913210560051792 1.0000000000000041e-14 13.999999999999998 -2.3561615738143393 KLDPELHLDIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLDPELHLDIK 11 1 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 31269200.0 12980000.0 13692000.0 4597200.0 False True 10793445.111498088 13618238.47835078 5558453.264948825 1.0 1.26171378440082 0.5149841600646574 23.36365208992477 -6.812006180376449 1.4060705351658676 1.1422960590829123 0.5013102046351998 0.8650083060309828 0.11366309460143742 0.20407466577420272 0.794799308589587 0.06355590717579891 0.14688971244242469 1.541678513409062e-07 6.812006180376449 -0.6409858544477125 KLDPELHLDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLDPELHLDIK 11 1 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 91543000.0 32326000.0 35120000.0 24097000.0 False True 41846644.24072353 33165541.12703887 19711593.25609958 1.0 0.792549599347884 0.4710435833924534 25.318608599260052 -6.964708792009717 0.3630158450244194 1.0267669931965486 0.22575672288217516 0.9999070150392457 0.0020984010149824556 0.07805992433552454 0.015209253619675775 0.004288185497927235 0.027411942097601987 1.0846539645388412e-07 6.964708792009717 -0.8010102703143734 down KLDPGSEETQTLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLDPGSEETQTLVR 14 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 28008410.0 603210.0 18543000.0 8862200.0 False True 790814.1514939491 15776456.680047888 7945224.556225119 1.0 19.94963879976622 10.046892232790187 19.592979162534114 -9.611961918034401 9.730650231882377 1.0000001295503749 14.998264470529739 0.7270932617436936 4.042779356864946 0.0 3.05513209252435e-17 3.9144038720783016 1.3048014267941295 2.4436448191005487e-10 9.611961918034401 13.998264340979365 KLDPGSEETQTLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLDPGSEETQTLVR 14 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 28980400.0 7661300.0 2131100.0 19188000.0 False True 7418096.225083603 2982059.3435396855 14162087.172338827 1.0 0.40199793222634794 1.9091269164790619 22.822617551447994 -6.799062916767992 1.4599114387793422 0.6696636069681405 1.9294134781949541 0.8293617199119633 0.2559622654662697 0.22209764621942618 0.934663278926725 0.13794101106132492 0.32095971694988856 1.588316630574007e-07 6.799062916767992 1.2597498712268136 KLDPGSEETQTLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLDPGSEETQTLVR 14 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 22819210.0 603210.0 10499000.0 11717000.0 False True 826233.0381373138 10035119.464449843 8949685.919189766 1.0 12.145628413835082 10.831914854634988 19.656189224057005 -10.521797261892585 16.588788486103113 0.9999998785199905 11.488771634235036 0.9883712383931544 0.5363213147026353 2.4298581204410576e-06 6.717050757795909e-08 0.5192908800034651 0.1730969600049477 3.0074799320070323e-11 10.521797261892585 10.488771755715046 KLDSK(ub)VNIIPIIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLDSKVNIIPIIAK 14 2 A0A087X142;A6NMH6;A6NFQ9;F8W8I8;Q92599-3;Q92599-2;Q92599-4;Q92599;C9JV02;D6RDU5;D6RGI3;D6RER5;Q9NVA2;Q9NVA2-2;Q14141;B1AMS2;Q14141-2;Q14141-4;Q14141-3 A0A087X142;D6RDU5;Q14141 SEPT8;SEPT11;SEPT6 Septin-8;Septin-11;Septin-6 1 5633700.0 1365100.0 1658500.0 2610100.0 True False 1869814.3604403897 1585221.9860739154 1993648.1366968725 1.0 0.8477964548847269 1.0662278453286222 20.834463612396142 -6.719347692745781 1.7617647517216555 0.9073363318389192 1.065872556662793 0.509395048510628 0.06405297061911129 0.3565844242463669 2.1626641857180746 0.028872808019919885 0.07253441040954282 1.90832485696631e-07 6.719347692745781 0.15853622482387375 KLDTNSDGQLDFSEFLNLIGGLAMACHDSFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLDTNSDGQLDFSEFLNLIGGLAMACHDSFLK 32 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 3270800000.0 1004900000.0 1238700000.0 1027200000.0 False True 1524506768.0306528 1017644306.9927261 824173469.7622472 1.0 0.6675236399949289 0.5406164715338776 30.50569540917655 -13.999999999999998 0.13346688978105029 2.5814770638461333 0.3704758964545483 0.9996302130988012 0.003724827210779496 11.932952096829828 0.11393825581357865 4.936329921028987 0.15153431320506316 1.0000000000000041e-14 13.999999999999998 -2.211001167391585 KLDVSIEMPEELDISQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLDVSIEMPEELDISQLR 18 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 25765100.0 6332000.0 11363000.0 8070100.0 False True 9606106.931207161 9335183.870475775 6475041.197749519 1.0 0.9717967889935469 0.6740546658620035 23.195520437473064 -6.925326557036909 0.7842032296294181 1.0053966088998638 0.6196195754905293 0.9955372938875506 0.009850490660206834 0.09513815091335812 0.09010761115748966 0.00873620238501893 0.02766502541128327 1.1876088983660967e-07 6.925326557036909 -0.38577703340933456 KLDVSIEMPEELDISQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLDVSIEMPEELDISQLR 18 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 0 19473400.0 6332000.0 5409300.0 7732100.0 False True 8196898.822380166 5108267.699843148 6324937.138045717 1.0 0.6231951632605172 0.7716256202622153 22.966646759565513 -10.061911359107121 5.0025634084054715 1.0000061377063687 0.6974103929957349 0.8471219204926574 0.06059648032969654 4.148193875959879e-06 7.777466904675394e-07 0.058673479403161075 0.019557429928785536 8.671388435093269e-11 10.061911359107121 -0.3025957447106338 KLDYGQHVVAGTPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLDYGQHVVAGTPGR 15 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 5675400.0 643400.0 2518600.0 2513400.0 False True 843503.6306944628 2142834.697425905 2253337.478235229 1.0 2.5403977166781053 2.671402227848195 19.686034752758335 -10.543999607843775 0.48646615789202774 5.079716141688143e-20 2.6682424654865535 0.9995900198263009 0.015366492197484713 1.9863057744331754 0.23141899725084267 2.4838864736323005 0.02729138046914406 2.8575931237034414e-11 10.543999607843775 2.6682424654865535 KLDYGQHVVAGTPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLDYGQHVVAGTPGR 15 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 5868270.0 1634900.0 898070.0 3335300.0 False True 1583000.9943990142 1256674.0343731816 2461684.8731447654 1.0 0.7938554927126105 1.5550747484396517 20.594230731062108 -6.834569983984502 1.3072307500338418 0.890144794825745 1.5775583682527825 0.9147297206830063 0.09387126518971897 0.17524033928619512 0.5840073375092624 0.05635075262755745 0.1297024911625499 1.4636256639360172e-07 6.834569983984502 0.6874135734270375 KLDYGQHVVAGTPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLDYGQHVVAGTPGR 15 1 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 5371900.0 643400.0 2125100.0 2603400.0 False True 881282.3672312258 2031206.055234053 1988530.538706037 1.0 2.304830019027394 2.2564056795479916 19.749244814281226 -10.09046174855696 5.428547664056446 0.9999852107603762 2.2806178492883604 0.9989287665385602 0.019769153811652784 3.5385414328686895e-06 5.928499374336081e-07 0.019141621252014237 0.006380466956422477 8.119667615472174e-11 10.09046174855696 1.2806326385279843 KLEAAEDIAYQLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLEAAEDIAYQLSR 14 1 P35232 P35232 PHB Prohibitin 0 10409500.0 2151800.0 4503300.0 3754400.0 False True 2821030.6380608394 3831425.193725913 3365930.7027478083 1.0 1.3581650415394328 1.1931563795640059 21.42779090385397 -10.454332130536718 5.755800910938182 0.9998006486179902 1.2756607105517197 0.7881863597219158 0.06736450416319831 0.00017245231505731929 1.6348968791835183e-05 0.06527211186610321 0.021741800229132156 3.512916843595895e-11 10.454332130536718 0.2758600619337295 KLEAAEDIAYQLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLEAAEDIAYQLSR 14 1 P35232 P35232 PHB Prohibitin 0 12005100.0 3390200.0 1490600.0 7124300.0 False True 3282579.9567016545 2085804.3533763108 5258232.105581276 1.0 0.6354161607299074 1.6018595662372723 21.64639872186871 -6.804491405212821 1.4373878532177957 0.7999719783686003 1.6167460423601476 0.8449970775018115 0.1568882821713983 0.21441063964936585 0.8740242379178935 0.08584609082801942 0.19913632731823763 1.5685869400676156e-07 6.804491405212821 0.8167740639915473 KLEAAEDIAYQLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLEAAEDIAYQLSR 14 1 P35232 P35232 PHB Prohibitin 0 14702800.0 2151800.0 4872400.0 7678600.0 False True 2947378.610208503 4657121.257127852 5865072.825731033 1.0 1.5800892498159234 1.9899285437632077 21.491000965376863 -7.516488265890284 0.10691526126950181 3.811401762821811e-18 3.3581032273903855 0.9999962501041473 0.0007864236242261432 0.13585134585425743 0.00967092959399211 0.11898511085990401 0.17286279545628414 3.0444702468017206e-08 7.516488265890284 3.3581032273903855 KLEDGPK(ub)FLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLEDGPKFLK 10 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 111995000.0 40523000.0 49197000.0 22275000.0 True False 53126045.42529029 41856999.36840401 19970196.67688775 1.0 0.7878809543101861 0.37590218727970814 25.662915990279444 -6.960614286285715 0.4266882426487379 1.016950996114372 0.13111947728799686 0.9997923072337157 0.003734101572090914 0.07948240839892524 0.02032589749735505 0.005355985273674239 0.03423411450534743 1.0949283827797665e-07 6.960614286285715 -0.885831518826375 down KLEDGPK(ub)FLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLEDGPKFLK 10 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 169423000.0 64045000.0 61418000.0 43960000.0 True False 62011926.53146054 85942527.69063888 32445557.228268467 1.0 1.385903204394684 0.5232147917837684 25.886042374760557 -6.785140086362068 1.5161297516106782 1.2170538811584004 0.5152819718006346 0.7850542247168171 0.16358542993988126 0.24267530552846892 1.102087892636999 0.08496072294381157 0.19960382111473124 1.6400606686394088e-07 6.785140086362068 -0.7017719093577658 KLEDGPK(ub)FLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLEDGPKFLK 10 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 296507000.0 82972000.0 73675000.0 139860000.0 True False 125874590.06571731 60527120.62459761 112216609.69718434 1.0 0.48085257392295994 0.891495333876342 26.907411838930802 -9.907795854453166 6.683609142105696 1.0000000157334283 0.6861739538996469 0.43780195530582067 0.16764420474235348 3.930458108918072e-08 6.514120813385526e-09 0.16232081293888484 0.05410693442127344 1.2365285425443152e-10 9.907795854453166 -0.3138260618337815 KLEDGPK(ub)FLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLEDGPKFLK 10 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 101231000.0 40523000.0 40526000.0 20182000.0 True False 55505448.1928987 38735427.31843922 15415427.261337204 1.0 0.6978671207882434 0.2777281827860177 25.726126051802336 -7.151788124772073 0.3678240682064426 1.0379143318425328 4.201153717205744e-14 0.9998415789850046 0.0037278164577376318 0.08225382585711635 0.01944439350164106 0.007595586293742404 0.038989011176712614 7.050369449252011e-08 7.151788124772073 -1.0379143318424908 down KLEDGPK(ub)FLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLEDGPKFLK 10 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 181734000.0 64045000.0 99799000.0 17890000.0 True False 53256255.17456809 99261362.9784495 21630716.285985887 1.0 1.8638442123480476 0.40616292330511794 25.666447650194833 -6.746153040146456 1.6642264612829638 1.5102808819684357 0.4041105659331097 0.6322410011750035 0.36294262923932963 0.3067780367203434 1.6704950073911415 0.17237498348243885 0.42016046034251836 1.794101295730755e-07 6.746153040146456 -1.106170316035326 KLEDGPK(ub)FLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLEDGPKFLK 10 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 240612000.0 82972000.0 99313000.0 58327000.0 True False 107408889.62263554 93786144.24685666 47712084.485559195 1.0 0.8731692933085866 0.4442098289367686 26.67853816102325 -6.948729341411464 0.5726287889691931 1.005281995486809 0.2911472488889057 0.9990977186497807 0.007143422491904065 0.08400013415724081 0.03810599568527331 0.007545523743791889 0.035764104288970575 1.1253060624577041e-07 6.948729341411464 -0.7141347465979033 down KLEDVK(ub)NSPTFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLEDVKNSPTFK 12 2 P55327-2;P55327;P55327-3;H0YC42 P55327-2 TPD52 Tumor protein D52 1 4625000.0 1212000.0 1034300.0 2378700.0 True False 1173525.7234152588 1447301.383803244 1755647.110529624 1.0 1.2332932759166355 1.496044846311714 20.162418035076943 -6.969582085699036 0.26797986463472967 0.9330614154154909 1.8041545547256115 0.9999789363860109 0.0009299476789174717 0.07643855614152627 0.009514328112923421 0.005214982030636072 0.024505967419435344 1.0725509065726219e-07 6.969582085699036 0.8710931393101206 KLEEEGEQFVK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLEEEGEQFVKK 12 2 P22307-7;P22307-8;P22307;P22307-6;P22307-2;P22307-4;H0YF61 P22307-7 SCP2 Non-specific lipid-transfer protein 1 38244700.0 11304000.0 18587000.0 8353700.0 True False 9399776.85210895 18486868.141769364 10100420.046855249 1.0 1.9667347887755038 1.0745382795538494 23.164195077372206 -6.627122569366664 2.0906766375424812 1.6382227264388707 1.0780696377510006 0.10729555745120656 0.41497869932701686 0.5665445895050484 4.715076287034655 0.16254713863275436 0.45985305131429544 2.3598121379139742e-07 6.627122569366664 -0.5601530886878701 KLELSDNIISGGLEVLAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLELSDNIISGGLEVLAEK 19 1 Q9BTT0;Q9BTT0-3;Q5TB19;E9PLC4 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 0 4945300.0 3001700.0 0.0 1943600.0 False True 2906412.6765475124 0.0 1434512.8532498323 1.0 0.0 0.49356819312867517 21.470808132631838 -10.460306445630204 6.910440635032599 1.0001404103793112 0.24678409656433922 0.756403874738445 0.20149837107211943 0.0004359706187379298 3.404854700080879e-05 0.19513534874476088 0.0650333196208534 3.464922732868781e-11 10.460306445630204 -0.753356313814972 KLELSDNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLELSDNR 8 1 H0YN26;P39687 H0YN26 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 0 9966200.0 3185900.0 1696700.0 5083600.0 False True 3084765.3483734922 2374201.1581736123 3752052.6552690077 1.0 0.7696537305262003 1.216317039235207 21.55672932008842 -6.7665072284405285 1.5875845682294265 0.8672945778234359 1.2185195139851677 0.7171364805998128 0.09699838834379786 0.27210133649546425 1.3528735158448484 0.04817264066294785 0.11505336052246147 1.7119566824885267e-07 6.7665072284405285 0.3512249361617318 KLELSDNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLELSDNR 8 1 H0YN26;P39687 H0YN26 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 0 13425320.0 572320.0 6287200.0 6565800.0 False True 783922.1703664527 6009410.715009905 5015093.266895636 1.0 7.665825693130663 6.397437725930469 19.580350901736352 -10.456052194645512 6.663227984782818 0.9985678563721273 7.031631709530566 0.967898474997644 0.5178172192544137 0.011013912574339363 0.0008991148130996464 0.5012498050053851 0.16712478887931498 3.4990311223106404e-11 10.456052194645512 6.033063853158438 KLEMHVYSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLEMHVYSK 9 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 14752600.0 3763800.0 3877500.0 7111300.0 False True 4934378.248691042 3298992.1143766204 6375490.892406366 1.0 0.6685730092239593 1.2920555683175712 22.234436880137487 -6.762272835103992 1.6037393614443392 0.8080359848589102 1.2946073119730173 0.7002520622300868 0.13944894327336782 0.27911140372914883 1.4153098339594048 0.06858730583571708 0.16446989500327866 1.7287299848081995e-07 6.762272835103992 0.4865713271141071 KLEMHVYSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLEMHVYSK 9 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 12518600.0 2218000.0 1578800.0 8721800.0 False True 2147590.8040718194 2209223.073333233 6437298.931608549 1.0 1.0286983298422396 2.997451339148719 21.034287701765702 -6.910073232078889 0.8952365309181368 0.9391846309826714 3.2522780574051295 0.9909491639771848 0.0889441287145706 0.10436958987479421 0.13850492942077988 0.07284612876712808 0.20119030295929005 1.2300613365763984e-07 6.910073232078889 2.313093426422458 up KLEMHVYSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLEMHVYSK 9 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 16571800.0 4171600.0 5993600.0 6406600.0 False True 6328622.184811096 4923995.251789465 5140332.701887466 1.0 0.778051700353865 0.8122356733862919 22.59346001155209 -10.886291576686563 10.964368067660756 1.0116066889726973 0.7951436868700784 0.9795434951835965 0.01395554855175109 0.0038535862446921368 3.996439180358769e-05 0.01315093551423512 0.00450413392734342 1.2992969629714244e-11 10.886291576686563 -0.21646300210261893 KLEMHVYSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLEMHVYSK 9 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 10439500.0 3763800.0 2681200.0 3994500.0 False True 5155378.572870509 2562735.71845727 3051081.369309852 1.0 0.49709942388000844 0.5918248924270586 22.29764694166038 -9.87525063564582 5.470970094576007 1.0000003199295278 0.5444621581506839 0.9685887444792987 0.03867151060795479 1.5091182109937569e-07 3.100321549858798e-08 0.037443555357998426 0.012481176378291391 1.3327520657663463e-10 9.87525063564582 -0.4555381617788439 KLEMHVYSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLEMHVYSK 9 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 7863200.0 2218000.0 3540400.0 2104800.0 False True 1844365.2740603045 3521327.162485626 2544903.9485043655 1.0 1.9092352323103274 1.3798264282550983 20.81469297719998 -10.336507857589439 5.07938757462436 0.999725141006441 1.6445308302828154 0.6640077097205521 0.21613023921242228 0.0006730063873801242 8.791085238877837e-05 0.2093542467962896 0.06975573475674354 4.6077843185744466e-11 10.336507857589439 0.6448056892763744 KLEMHVYSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLEMHVYSK 9 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 22069000.0 4171600.0 9329300.0 8568100.0 False True 5400218.434529556 8810116.253886204 7008793.7161301 1.0 1.6314370169831296 1.297872262224644 22.36458633364454 -10.130740218536445 4.711468215818973 0.9999671137986724 1.4646546394872173 0.7212351996976123 0.13617724093027056 5.334982824982582e-05 9.843185256111892e-06 0.13186360733928745 0.043951015515246376 7.40047816294865e-11 10.130740218536445 0.4646875256885449 KLENCNYAVELGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLENCNYAVELGK 13 1 P13796;P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13796;P13797 LCP1;PLS3 Plastin-2;Plastin-3 0 41062200.0 4295200.0 19054000.0 17713000.0 False True 5631048.794775968 16211217.471910268 15880228.675093735 1.0 2.878898418878864 2.8201191738608493 22.424972221666135 -10.27805505662796 5.180015190510143 0.9996632011286798 2.8495087963701993 0.9992430492401829 0.023996526294556876 9.335200800212833e-05 1.3010518986137597e-05 0.02323838533124613 0.0077448455586318935 5.271630273743341e-11 10.27805505662796 1.8498455952415194 KLENCNYAVELGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLENCNYAVELGK 13 1 P13796;P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13796;P13797 LCP1;PLS3 Plastin-2;Plastin-3 0 36770200.0 4295200.0 17242000.0 15233000.0 False True 5883251.513415547 16480191.428330706 11635279.13348278 1.0 2.8012046384131315 1.97769534532918 22.488182283189026 -10.514052573103482 7.328924881521999 0.9996186175744556 2.3894499918710985 0.7914782290779837 0.3361962610826276 0.0020955930178798853 0.00013894871318975236 0.32559643350496004 0.10850687668585142 3.0615927930675384e-11 10.514052573103482 1.389831374296643 KLFETQESGDLNEELVK(ub)AAANGDVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLFETQESGDLNEELVKAAANGDVAK 26 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 40196600.0 9860600.0 11495000.0 18841000.0 True False 9547580.650419548 16085013.445633085 13905976.8821157 1.0 1.6847214005912863 1.4564922142348837 23.186703770971533 -10.12338170319135 4.7622268317838525 0.9999618341699915 1.5706068074183201 0.8928684894411957 0.09317417518195945 3.775867001971759e-05 6.9508402014671675e-06 0.09022152590831195 0.030071835728807228 7.526937273442576e-11 10.12338170319135 0.5706449732483286 KLFETQESGDLNEELVK(ub)AAANGDVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLFETQESGDLNEELVKAAANGDVAK 26 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 181792300.0 6960300.0 119257000.0 55575000.0 True False 10559283.966089888 97974656.59080623 44590576.89061214 1.0 9.278532228647538 4.22287884612351 23.332008671862887 -10.377582521487504 7.395560453425282 0.9998571653090268 6.750705537384866 0.6330474829799657 2.063961850593308 0.004880635802702181 0.00041077752331948147 1.998460375336071 0.6661408228796064 4.19196336469201e-11 10.377582521487504 5.75084837207584 KLFETQESGDLNEELVK(ub)AAANGDVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLFETQESGDLNEELVKAAANGDVAK 26 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 38558600.0 9860600.0 14253000.0 14445000.0 True False 8199525.7986469865 14176216.260001011 17465382.71386618 1.0 1.7289068426786638 2.1300479006661783 22.96710904640581 -9.473234527231895 0.1557123436906816 2.2597932629734477e-20 2.7329758401273585 0.9997576381861267 0.007282133929310711 0.9247611428799547 0.061587658666715776 0.7283605423568921 0.31618978194738007 3.363298958232376e-10 9.473234527231895 2.7329758401273585 KLFETQESGDLNEELVK(ub)AAANGDVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLFETQESGDLNEELVKAAANGDVAK 26 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 151076300.0 6960300.0 113187000.0 30929000.0 True False 9010245.558024736 106888043.95063065 25300239.3583394 1.0 11.862944607035004 2.807941159362345 23.103134993955337 -6.601381459420089 2.185203882061905 8.29895211072892 2.8375197851056666 0.024566250898165887 4.693634433363546 0.6368390912833843 5.749029955553141 1.7814826563300574 5.220498936138837 2.5039089965093263e-07 6.601381459420089 -5.461432325623253 KLFFHVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLFFHVK 7 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 9601700.0 2856600.0 2749100.0 3996000.0 False True 3745030.263353748 2338944.995907871 3582532.2523386506 1.0 0.6245463538159235 0.9566096934902798 21.83654594638309 -10.243576986939072 7.789503638050473 1.0000002684494025 0.7905780236531016 0.3465436592690485 0.13556429074777704 6.320166615949221e-07 6.126778958582111e-08 0.13125972830785912 0.04375318670054673 5.707198962712177e-11 10.243576986939072 -0.2094222447963009 KLFFHVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLFFHVK 7 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 6726500.0 2959500.0 1043300.0 2723700.0 False True 2865552.292448397 1459895.1307376267 2010281.2607514726 1.0 0.5094637897849204 0.7015336157183996 21.450381793048706 -10.148475614910852 5.287192966392385 1.0000124129411414 0.605498702751459 0.8490550672438523 0.07841217808773866 1.1473572533892917e-05 1.8477948996139735e-06 0.0759246514763749 0.02530742165603693 7.104350589184618e-11 10.148475614910852 -0.3945137101896824 KLFFHVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLFFHVK 7 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 12278800.0 4330300.0 2913000.0 5035500.0 False True 6569381.687335188 2393152.3906271197 4040231.217861943 1.0 0.36428883333735496 0.6150093585901579 22.647326159263965 -10.302470361187734 5.706811299994445 1.0000533579165591 0.4896490959637945 0.8467326727550879 0.10235622581867371 6.949505476222306e-05 8.494072626904877e-06 0.09911630181946156 0.03303532983136188 4.983444647702147e-11 10.302470361187734 -0.5104042619527647 KLFFHVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLFFHVK 7 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 8716000.0 2856600.0 2635700.0 3223700.0 False True 3912762.216712339 2519246.0589056523 2462328.4541855464 1.0 0.6438536050428397 0.6293069493638932 21.89975600790598 KLFFHVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLFFHVK 7 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 7936100.0 2959500.0 2772800.0 2203800.0 False True 2460955.378080012 2757862.376042291 2664604.3907800824 1.0 1.1206470465116358 1.0827520135123105 21.230787068482982 -10.069881104083382 4.335976976584708 0.9999908543163291 1.1016995300246037 0.9056880643364403 0.015470582483882004 10736748.832366621 0.001540156425709074 1010.4576875631336 0.005295991870966213 8.513710844300579e-11 10.069881104083382 0.10170867570827469 KLFFHVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLFFHVK 7 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 23690800.0 4330300.0 10694000.0 8666500.0 False True 5605658.712974235 10098869.4992185 7089285.925799366 1.0 1.8015491160467505 1.2646659899917367 22.418452481356415 -10.222776647096158 4.600746420071566 0.9998584196228626 1.5331075530230096 0.567968534625742 0.21918161840377884 0.00031838750514306025 5.378652881410589e-05 0.21227756083741864 0.07074056315422915 5.987194307526245e-11 10.222776647096158 0.533249133400147 KLFIGMISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLFIGMISK 9 1 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4 G5EA30 CELF1 CUGBP Elav-like family member 1 0 19317100.0 5017400.0 6104900.0 8194800.0 False True 6577859.988570717 5194072.716713821 7346880.706072265 1.0 0.7896295642866707 1.1169104722261878 22.649186869692013 -6.733104749067873 1.711735899000186 0.8738426663251725 1.11683578937583 0.5737002985505433 0.08841508227360705 0.33043568660257894 1.8981046439791922 0.04090786636433394 0.10116198049272136 1.8488226409301788e-07 6.733104749067873 0.24299312305065757 KLFIGMISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLFIGMISK 9 1 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4 G5EA30 CELF1 CUGBP Elav-like family member 1 0 12872000.0 5567600.0 1892900.0 5411500.0 False True 5390859.585550164 2648744.8413430927 3994065.8084798683 1.0 0.4913399800734701 0.7408959081749583 22.362083901844652 -10.135290080273622 5.1779987559940945 1.0000127858833407 0.616117944123821 0.7593257823606865 0.10188078102393126 1.5038357406466558e-05 2.5113770724648306e-06 0.09864892507140396 0.032881880683492945 7.323352177741533e-11 10.135290080273622 -0.3838948417595197 KLFIGMISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLFIGMISK 9 1 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4 G5EA30 CELF1 CUGBP Elav-like family member 1 0 34754100.0 12791000.0 8778100.0 13185000.0 False True 19404882.147357993 7211579.4713916555 10578978.970809218 1.0 0.3716373754103693 0.5451709982299255 24.209916335369503 -10.781317575808622 10.657812654448572 1.0025292921172795 0.45840418682059564 0.928507061526645 0.07084480485408465 0.004261186392340861 8.74330248225224e-05 0.06865100977760315 0.022865062447098673 1.6545596320066052e-11 10.781317575808622 -0.5441251052966838 KLFIGMISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLFIGMISK 9 1 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4 G5EA30 CELF1 CUGBP Elav-like family member 1 0 15209500.0 5017400.0 5569400.0 4622700.0 False True 6872468.370136702 5323325.492457082 3530913.467494971 1.0 0.7745871215048158 0.5137766050460173 22.712396931214904 -6.969212280432497 0.2763531115273631 1.0600400225794517 0.22041560466060175 0.9999755692835133 0.0009819833209464798 0.07655914059473279 0.00994152327155569 0.004920974790645387 0.024051342910116104 1.0734645812963467e-07 6.969212280432497 -0.83962441791885 KLFIGMISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLFIGMISK 9 1 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4 G5EA30 CELF1 CUGBP Elav-like family member 1 0 45571000.0 12791000.0 19269000.0 13511000.0 False True 16558201.648304597 18196663.211187683 11052136.634567033 1.0 1.0989516613992227 0.6674720400991534 23.981042657461952 -6.846394738655604 1.2524913825979453 1.0526811397477767 0.6513982657114583 0.9348733115141002 0.047098001800506877 0.16146962875426585 0.4892798753768763 0.029451201335203403 0.06800801879263427 1.4243124199767237e-07 6.846394738655604 -0.40128287403631835 KLFIGMVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLFIGMVSK 9 1 Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3;V9GYD9 Q5VZZ6 CELF2 CUGBP Elav-like family member 2 0 14468700.0 4025000.0 3718200.0 6725500.0 False True 5276813.978155451 3163459.0534300823 6029609.775551451 1.0 0.5995017195083865 1.1426610451898374 22.331235694882302 -6.709146277146078 1.7980958341178042 0.7535660742548268 1.141359963299956 0.4610588683562664 0.1687910254813778 0.3768240201323625 2.3743573926091823 0.07471488835904495 0.19001850938499665 1.953681314648201e-07 6.709146277146078 0.38779388904512924 KLFIGMVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLFIGMVSK 9 1 Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3;V9GYD9 Q5VZZ6 CELF2 CUGBP Elav-like family member 2 0 8078500.0 3562400.0 1581600.0 2934500.0 False True 3449313.5619591707 2213141.1279350417 2165866.4168870305 1.0 0.6416178431392021 0.6279123013846393 21.717877853159532 KLFIGMVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLFIGMVSK 9 1 Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3;V9GYD9 Q5VZZ6 CELF2 CUGBP Elav-like family member 2 0 23912900.0 6692900.0 0.0 17220000.0 False True 10153618.61653135 0.0 13816459.45220587 1.0 0.0 1.360742408594209 23.275490640857903 -6.70977889389989 1.7961937573576514 0.38507984670947965 1.3574998765243251 0.4639844128794527 0.42140863651335286 0.3755069126274861 2.3615262158962365 0.18672058799980443 0.47444963729429424 1.950837548822505e-07 6.70977889389989 0.9724200298148455 KLFIGMVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLFIGMVSK 9 1 Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3;V9GYD9 Q5VZZ6 CELF2 CUGBP Elav-like family member 2 0 6557200.0 3562400.0 1724500.0 1270300.0 False True 2962293.441078639 1715209.776213551 1535913.8567964153 1.0 0.579014135611428 0.5184880861219319 21.49828312859381 -13.999999999999998 0.2731814488973815 4.3055465524460965 0.499008704492665 0.9995902077894144 0.004335126393402585 15.041442195980814 0.16548538253847825 27.66568133993958 0.02474436377226436 1.0000000000000041e-14 13.999999999999998 -3.8065378479534315 KLFIGMVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLFIGMVSK 9 1 Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3;V9GYD9 Q5VZZ6 CELF2 CUGBP Elav-like family member 2 0 47948900.0 6692900.0 25885000.0 15371000.0 False True 8664090.986782737 24444476.995256286 12573635.719778677 1.0 2.821355065701281 1.4512354197295525 23.046616962950353 -6.573641987537623 2.291976111451524 2.2450119252199547 1.4542709615551885 0.0 0.792523883548617 0.7186997387240164 7.092200113094431 0.29151652301143105 0.8874539484469972 2.669058006946969e-07 6.573641987537623 -0.7907409636647662 KLFLVQLQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLFLVQLQEK 10 1 O43809;H3BND3 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 10913200.0 3755400.0 4420500.0 2737300.0 False True 4923365.76734533 3760978.630974038 2454070.454035684 1.0 0.763903965031213 0.49845381594691357 22.231213493770632 -6.969605614692322 0.26744099773690067 1.068069984422356 0.18633477206466573 0.9999791393303364 0.000935705024351441 0.07643090930480637 0.009487258108231157 0.0052861752278176265 0.024776377106813584 1.0724928000100688e-07 6.969605614692322 -0.8817352123576903 down KLFLVQLQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLFLVQLQEK 10 1 O43809;H3BND3 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 14259600.0 6705600.0 2251900.0 5302100.0 False True 6492734.398459869 3151095.4135033656 3913320.9504095167 1.0 0.48532640026840335 0.6027230917281614 22.63039476284725 -9.868482959012786 6.636992130045352 1.0000000140952106 0.5440247459983312 0.9526392150135466 0.04792699859463374 9.98505524484869e-09 1.7190901093938586e-09 0.046405117884880914 0.015468372282549311 1.3536832058884194e-10 9.868482959012786 -0.4559752680968794 KLFLVQLQEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLFLVQLQEK 10 1 O43809;H3BND3 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 29607300.0 5979300.0 12584000.0 11044000.0 False True 9071035.245383285 10338286.880759226 8861148.559242837 1.0 1.1397030880263541 0.9768618817518905 23.11283577919053 -6.679654057378481 1.9034748995728727 1.0884219361949223 0.9774889998269977 0.3223660529033441 0.0592144227696779 0.43930197079313227 3.0771698033585966 0.024966662453815507 0.06586844070789497 2.0909610484514612e-07 6.679654057378481 -0.11093293636792467 KLFLVQLQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLFLVQLQEK 10 1 O43809;H3BND3 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 21702400.0 3755400.0 5144000.0 12803000.0 False True 5143872.865869048 4916721.071066761 9779195.086061839 1.0 0.9558403170674185 1.9011346782984033 22.294423555293523 -6.895940346121739 0.986549174575167 0.9562019279264398 1.9925783775678136 0.9844368953881585 0.054339643206804705 0.11445654957043327 0.19473855331240428 0.04160461659273258 0.10620635504542517 1.2707486408793782e-07 6.895940346121739 1.0363764496413739 KLFLVQLQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLFLVQLQEK 10 1 O43809;H3BND3 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 11976800.0 6705600.0 2364400.0 2906800.0 False True 5576003.508448501 2351662.5079033435 3514598.440475342 1.0 0.42174695628153996 0.6303077885711846 22.410800038281526 -10.107992488166584 5.174435539915605 1.0000114846533301 0.5260273724256803 0.8731962475002613 0.0851446032423613 1.1281094073209721e-05 1.9444861144423795e-06 0.08244290474487985 0.027480302531081073 7.798435990771983e-11 10.107992488166584 -0.4739841122276498 KLFLVQLQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLFLVQLQEK 10 1 O43809;H3BND3 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 32255300.0 5979300.0 15100000.0 11176000.0 False True 7740321.71962377 14259671.7260332 9142082.675443785 1.0 1.8422582733067991 1.1810985391299924 22.88396210128298 -10.274660330772829 4.905874140213755 0.9998585600926492 1.5116784062188147 0.44400678913591873 0.26991733120267164 0.00041767611728064257 6.175399151071868e-05 0.2614178922759165 0.08711544404985165 5.312998205539391e-11 10.274660330772829 0.5118198461261655 KLFVGGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLFVGGLK 8 1 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 104380000.0 35645000.0 36326000.0 32409000.0 False True 46730940.18667099 30906302.397638958 29055627.569079943 1.0 0.6613670145342876 0.621764241271727 25.477874727500335 -13.999999999945945 0.30282803451998974 4.139654759789139 0.6123025029463125 0.9996561303073301 0.0031475940001210716 16.774940336201574 0.1748510062016834 33.0535433889098 0.014140344909266463 1.0000000001244652e-14 13.999999999945945 -3.5273522568428266 KLFVGGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLFVGGLK 8 1 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 79561400.0 31081000.0 8197400.0 40283000.0 False True 30094350.667879235 11470664.568876276 29731673.835903972 1.0 0.38115673919887305 0.9879486739561933 24.842989352911676 -10.848991053188303 10.887204078077191 1.0071591519221577 0.6845527065868009 0.264889782663399 0.2477217700319359 0.042651253286577505 0.0005915851208098506 0.23764972556001898 0.07995185748555929 1.4158229467352765e-11 10.848991053188303 -0.32260644533535676 KLFVGGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLFVGGLK 8 1 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 138842800.0 22954000.0 94793000.0 21095800.0 False True 34822896.16218089 77876448.52891059 16926205.88338241 1.0 2.2363576012235202 0.48606542673969116 25.053532858730158 -6.716921781846979 1.7702565570750581 1.7546539113941484 0.4892352454841693 0.49796090003117943 0.5204718074710969 0.3613603808500005 2.211404903031526 0.23359396148399264 0.5885719284662212 1.919014331615477e-07 6.716921781846979 -1.265418665909979 KLFVGGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLFVGGLK 8 1 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 82892500.0 35645000.0 19251500.0 27996000.0 False True 48823919.76990524 18400905.07380283 21383921.39571879 1.0 0.37688299424793487 0.4379804304221331 25.541084789023227 -10.180465254828011 4.883070772253712 1.0000556348299177 0.40743171233410924 0.9920899089411416 0.024942923951190105 1.6024135707411977e-05 2.6893961677455383e-06 0.02415327611174904 0.008050294076848085 6.59986033486046e-11 10.180465254828011 -0.5926239224958084 KLFVGGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLFVGGLK 8 1 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 61868500.0 31081000.0 20172200.0 10615300.0 False True 25845228.621762063 20063528.354731783 12834910.150398321 1.0 0.7762952554359684 0.4966065627909028 24.623394628345952 -6.968106658569279 0.29998251526673636 1.048517457162628 0.2156207540271646 0.9999636185326624 0.0012421119766799567 0.07692196114831427 0.01121739231620265 0.004640522169902929 0.025084488027472845 1.0762008765340103e-07 6.968106658569279 -0.8328967031354633 down KLFVGGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLFVGGLK 8 1 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 103488000.0 22954000.0 43844000.0 36690000.0 False True 29714405.4909846 41404042.85802654 30012796.471191186 1.0 1.3933996717716124 1.0100419636629485 24.824659180822607 -9.420170455312636 9.550021100519862 0.9999993419708548 1.201720812423723 0.26963294314030595 0.15650512897197005 0.0 0.0 0.15153543952591167 0.05051181317530388 3.800402058769175e-10 9.420170455312636 0.20172147045286826 KLGCEVLGVSVDSQFTHLAWINTPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLGCEVLGVSVDSQFTHLAWINTPR 25 1 P32119;A6NIW5 P32119 PRDX2 Peroxiredoxin-2 0 75417800.0 22882800.0 21434000.0 31101000.0 False True 34714880.55676361 17608935.23539365 24953873.717947464 1.0 0.5072445865570707 0.718823551103523 25.04905087178833 -10.273046146805035 5.64400366010532 1.0000305311050026 0.6130340688302907 0.8168513198908268 0.08637675057422686 3.318658118419231e-05 4.27441774553678e-06 0.08364051493526196 0.02787797637278765 5.3327822796148384e-11 10.273046146805035 -0.38699646227471196 KLGCEVLGVSVDSQFTHLAWINTPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLGCEVLGVSVDSQFTHLAWINTPR 25 1 P32119;A6NIW5 P32119 PRDX2 Peroxiredoxin-2 0 60641200.0 22882800.0 26889400.0 10869000.0 False True 29622235.687422745 25392981.25231775 8890953.525357787 1.0 0.8572270344570687 0.3001445812252713 24.82017719388078 -6.945446255499773 0.606790369720427 1.0061927724437438 0.12232751366740068 0.9987936532097001 0.01048721173116006 0.08536765771245139 0.04394014174341532 0.010692650887670576 0.04692218411438977 1.1338451442173491e-07 6.945446255499773 -0.8838652587763431 down KLGIQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLGIQVK 7 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 6941400.0 2139300.0 2345400.0 2456700.0 False True 2804643.017010668 1995475.4622975925 2202504.250330424 1.0 0.7114900007575554 0.7853064496878344 21.419385721490343 -10.274907873045327 5.611315482284029 1.0000214779596523 0.7483982252226902 0.9393582887174268 0.03013543908391706 8.097948438662277e-06 1.046422056559273e-06 0.029181002027735867 0.009726171141885679 5.3099707277463146e-11 10.274907873045327 -0.2516232527369622 KLGIQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLGIQVK 7 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 5888760.0 1718100.0 852260.0 3318400.0 False True 1663559.8559403927 1192571.8624771873 2449211.490133898 1.0 0.7168794427315867 1.4722713351058743 20.66584234556288 -6.805167210279469 1.4345553248600635 0.8447988163676585 1.4841003272212556 0.8468925691437409 0.12192323347258496 0.21345812993505706 0.8666124068004616 0.0668432005982534 0.15500166039179922 1.5661479621501958e-07 6.805167210279469 0.6393015108535971 KLGIQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLGIQVK 7 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 5709000.0 2139300.0 1664900.0 1904800.0 False True 2930257.022408705 1591339.2129119453 1454925.4705874086 1.0 0.5430715465375273 0.49651803901878994 21.482595783013235 -13.999999999999998 0.32277187193721896 5.763030173304252 0.48755896599382065 0.9996996478236704 0.003936957995191858 18.23116963471834 0.18131197665084767 58.725646471466995 0.015333404280777802 1.0000000000000041e-14 13.999999999999998 -5.2754712073104315 KLGIQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLGIQVK 7 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 3814160.0 1718100.0 1428100.0 667960.0 False True 1428676.2747353504 1420406.5418443428 807627.3477019073 1.0 0.9942116117995033 0.5652976548879228 20.446247620997156 -6.909841521727474 0.896815125498019 1.0133466789691525 0.5100555424181976 0.9908615828656474 0.019460290197611266 0.10452286953893564 0.1393370567179115 0.01591992615596129 0.04389799665141458 1.2307177897508577e-07 6.909841521727474 -0.5032911365509549 KLIELQAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLIELQAGK 9 1 K7ELL7;P14314-2;P14314;K7EPW7 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 7643500.0 2684400.0 2701400.0 2257700.0 False True 3519274.395766578 2298361.6499747275 2024094.86138763 1.0 0.6530782745271251 0.5751455083532172 21.746846573885872 -13.999999999999998 0.20982226467165732 3.0049073893842095 0.5291639861413768 0.9994899119896019 0.004170808313499845 12.7425309935573 0.14518815364041032 10.5311889112853 0.046221050579480824 1.0000000000000041e-14 13.999999999999998 -2.4757434032428325 KLIELQAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLIELQAGK 9 1 K7ELL7;P14314-2;P14314;K7EPW7 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 5881880.0 1664700.0 839980.0 3377200.0 False True 1611855.0097107103 1175388.3944378323 2492610.006171707 1.0 0.7292147168055684 1.5464232149634052 20.620290545088917 -6.817386245257933 1.383028157506517 0.8536482411310371 1.5633001840716145 0.8782903765945917 0.11857743771433064 0.19690018315296046 0.7407228335613518 0.06738477355487162 0.1554384975407671 1.5226979208766967e-07 6.817386245257933 0.7096519429405774 KLIELQAGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLIELQAGK 9 1 K7ELL7;P14314-2;P14314;K7EPW7 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 13776600.0 1553000.0 9978800.0 2244800.0 False True 2356014.5395080093 8198005.17527975 1801114.2960692083 1.0 3.479607208617517 0.7644750343711049 21.167917011723183 -6.666423849607702 1.9495374278537836 2.5876087566311123 0.7755167926030974 0.2632897846750949 1.0541705342241412 0.46953039246878103 3.4367381445510046 0.4357971326645705 1.1700156973441183 2.1556395862210178e-07 6.666423849607702 -1.8120919640280149 KLIELQAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLIELQAGK 9 1 K7ELL7;P14314-2;P14314;K7EPW7 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 6993500.0 2684400.0 1777200.0 2531900.0 False True 3676895.223182318 1698677.4275855073 1933917.3661173137 1.0 0.4619869004902778 0.5259647742813641 21.810056635408763 -10.275508283186877 5.5888306478622445 1.0000451970140354 0.4939758373867673 0.9881531567282936 0.026118857602763373 1.4710435417328752e-05 1.9069283815990755e-06 0.025291725334630134 0.00842982504311637 5.302634789539093e-11 10.275508283186877 -0.5060693596272681 KLIELQAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLIELQAGK 9 1 K7ELL7;P14314-2;P14314;K7EPW7 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 5576800.0 1553000.0 2492700.0 1531100.0 False True 2010389.1142066314 2353979.053740598 1252455.5104126686 1.0 1.1709071826473547 0.6229915898181385 20.939043333815633 -6.822912628921899 1.3594055388127093 1.0918537983232006 0.6102832560296295 0.8909175715786659 0.07560017975941538 0.18972159827371823 0.6881333160580537 0.04369479976303102 0.10063077287493631 1.5034443976221521e-07 6.822912628921899 -0.4815705422935711 KLIELQAGKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLIELQAGKK 10 2 K7ELL7;P14314-2;P14314;K7EPW7 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 2719680.0 1161300.0 380080.0 1178300.0 False True 1522475.546045198 323373.5455402361 1056380.8190517093 1.0 0.21239982893665213 0.6938573311051055 20.537987625119065 -10.06295123970957 5.538245615188965 1.0000035341006948 0.4531285800368876 0.6323876432442451 0.19655420219211156 8.57712277450513e-06 1.451180121948106e-06 0.19031401547202673 0.063437595976306 8.650650382566741e-11 10.06295123970957 -0.5468749540638072 KLIELQAGKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLIELQAGKK 10 2 K7ELL7;P14314-2;P14314;K7EPW7 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 8881700.0 1216700.0 4694400.0 2970600.0 False True 1845822.852684738 3856647.6424853904 2383459.6079397677 1.0 2.08939207620922 1.2912721307318522 20.81583267061956 -10.048827930224398 4.426551384072533 0.9999603592818725 1.6903321031744563 0.49937746630771485 0.32583110357080863 42670533.56422256 24216873.584730558 16239.558942729862 0.1115406554917472 8.936594862248987e-11 10.048827930224398 0.6903717438925837 KLIELQAGKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLIELQAGKK 10 2 K7ELL7;P14314-2;P14314;K7EPW7 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 3128350.0 1161300.0 1304100.0 662950.0 False True 1590663.9929524767 1246480.5499179938 506374.8638838321 1.0 0.7836227861073072 0.3183418158249344 20.601197686641957 -6.958603230611961 0.454694658904316 1.0143049212774113 0.06906935694536467 0.9997148249542972 0.004802738623353612 0.0802039474271987 0.023004103775055344 0.00626408972166058 0.03846125016428226 1.1000103447639977e-07 6.958603230611961 -0.9452355643320467 down KLIELQAGKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLIELQAGKK 10 2 K7ELL7;P14314-2;P14314;K7EPW7 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 5723500.0 1216700.0 2273800.0 2233000.0 False True 1575042.13474257 2147261.031169163 1826616.9125148517 1.0 1.363303865848718 1.1597257446153335 20.58695899271201 -10.169612966971142 4.230750909664656 0.9999219300915837 1.2615148052549288 0.6875229583261858 0.08311042004942992 58250772.65085365 6.99687953463761 45526.764516989366 0.028450907378611872 6.766857531908408e-11 10.169612966971142 0.26159287516334506 KLIK(ub)DGLIIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLIKDGLIIR 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 14910600.0 2796200.0 4970100.0 7144300.0 True False 2707436.1615624987 6954686.848729103 5272993.50559414 1.0 2.568735302964801 1.9475966157410791 21.368495890358886 -10.359055329032536 5.551645797947585 0.9996521171458523 2.2581659593528998 0.845455571740098 0.25357880720009374 0.0010921642791223958 0.0001260917544297182 0.24558959368256375 0.08184220810308607 4.3746636847763756e-11 10.359055329032536 1.2585138422070474 KLIK(ub)DGLIIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLIKDGLIIR 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 10935400.0 2796200.0 6094700.0 2044500.0 True False 2325164.1926634014 6061866.641396763 2471995.4973000633 1.0 2.6070703568048192 1.0631487897069631 21.148901165793163 -6.636812974074208 2.0561587593341835 2.0534603485058884 1.0695419426310246 0.14248246285868704 0.6881672956976895 0.5414112573805775 4.370769393009142 0.2729379274367823 0.7619649990562596 2.3077407874283417e-07 6.636812974074208 -0.9839184058748638 KLIK(ub)DGLIIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLIKDGLIIR 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 31414200.0 5172100.0 7780100.0 18462000.0 True False 6695385.407332994 7347130.595742445 15102105.436116992 1.0 1.0973424453946505 2.25559912048927 22.674735673304596 -6.923513906420496 0.7982119241316139 0.9775350148470152 2.4583721166854007 0.9951032110929766 0.03991053723733304 0.09614751918813608 0.09521510556764687 0.03504355372376223 0.10877739365521566 1.1925760781038869e-07 6.923513906420496 1.4808371018383855 up KLIYFQLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLIYFQLHR 9 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 162376100.0 35087700.0 64293400.0 62995000.0 False True 46000314.48977011 54701075.333710335 56476881.69070906 1.0 1.1891456817295274 1.2277499038244362 25.4551403886699 -13.671611929382312 0.22724725974076188 3.142360838101311e-08 1.2472584152691781 0.99948920700674 0.0022491960399351973 11.384584598750829 0.1494129605444618 5.121622478476 0.020402171390030484 2.1300415277368848e-14 13.671611929382312 1.2472583838455698 KLIYFQLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLIYFQLHR 9 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 117012330.0 50712900.0 31881340.0 34418090.0 False True 49103046.74833805 44611725.32099178 25402959.708432518 1.0 0.9085327342239046 0.5173397862382605 25.549309207943935 -6.943339867882607 0.6277228328879381 1.0042678511212342 0.400603618925733 0.9985694556310536 0.007917265524784167 0.0862754534640133 0.047915265893191346 0.007918034215214594 0.033205801224146694 1.1393578059694944e-07 6.943339867882607 -0.6036642321955012 KLIYFQLHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLIYFQLHR 9 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 974388000.0 235140000.0 292800000.0 446448000.0 False True 356724571.0366474 240547552.34315845 358207357.11489004 1.0 0.674322914298063 1.0041566693147423 28.41023535054661 -10.982328781286988 10.567538785623906 1.1045772628908133 0.8392397918064025 0.24054978244583836 0.13465406662283594 0.07388282657326176 0.00012354806817932613 0.02903464462356293 0.04345941312744564 1.0415286448358245e-11 10.982328781286988 -0.26533747108441075 KLIYFQLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLIYFQLHR 9 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 191634840.0 35087700.0 61047540.0 95499600.0 False True 48060570.89943903 58350257.825581454 72944561.35600038 1.0 1.2140983083133232 1.5177631058238594 25.51835045019279 -6.966171037172335 0.3373555789950636 0.9660377243240656 1.7758749393501492 0.9999352837759498 0.0017088929889470335 0.07756585067233755 0.01347132010901975 0.004322212606062278 0.026335084862845106 1.0810081365677523e-07 6.966171037172335 0.8098372150260835 KLIYFQLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLIYFQLHR 9 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 107152150.0 50712900.0 26266000.0 30173250.0 False True 42170023.31239533 26124499.844607204 36482337.06965475 1.0 0.6195040408461963 0.8651248968821709 25.32971448337821 -10.57755578582434 6.424961391252397 1.00049762508854 0.7423144688641836 0.5947371769780566 0.10027429457895724 0.0007161079699719059 4.708436705781584e-05 0.09727238805201825 0.03236338941308316 2.6451129038965902e-11 10.57755578582434 -0.2581831562243564 KLIYFQLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLIYFQLHR 9 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 1364287300.0 235140000.0 576738000.0 552409300.0 False True 304393365.3023486 544642023.3065532 451876475.59807044 1.0 1.7892703501128213 1.4845148649978932 28.18136167263906 -10.177057335187296 5.181074075996552 0.9999652993051718 1.6368926075557486 0.8534430390619074 0.12441590580902083 4.987238503031397e-05 7.921443387760937e-06 0.1204717247903824 0.04015506093327417 6.651853332040432e-11 10.177057335187296 0.6369273082505769 KLIYQTLSWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLIYQTLSWK 10 1 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;O95453-3;A0A494C0Q6;A0A494C0K5;A0A494C1G3;A0A494C002;H3BRK1;F5H1Z4 O95453 PARN Poly(A)-specific ribonuclease PARN 0 6494630.0 2769400.0 748330.0 2976900.0 False True 2681486.912892918 1047142.0714893964 2197160.584914295 1.0 0.3905079925822531 0.8193814313805066 21.35460178157043 -9.978265833283805 6.907620811032299 1.0000000345864262 0.6049447119813789 0.5308133524532279 0.17508684821474865 9.341801775035739e-08 1.3531084001690832e-08 0.16952712697576863 0.05650903727297175 1.0513181610381546e-10 9.978265833283805 -0.3950553226050473 KLIYQTLSWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLIYQTLSWK 10 1 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;O95453-3;A0A494C0Q6;A0A494C0K5;A0A494C1G3;A0A494C002;H3BRK1;F5H1Z4 O95453 PARN Poly(A)-specific ribonuclease PARN 0 29899700.0 2565700.0 13437000.0 13897000.0 False True 3321349.227508022 12689219.137927718 11367888.595261484 1.0 3.8205013290482324 3.4226718771728524 21.663337994153707 -9.89659105073235 6.005552934490697 0.9999993820780027 3.621586603111767 0.9830218686894862 0.1624131936286589 55388387.58988324 6.4522322979451605 474.3653237236156 0.055598356116116056 1.268846100360304e-10 9.89659105073235 2.6215872210337645 KLK(ub)EDKAPQVDVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLKEDKAPQVDVDK 14 3 P41250 P41250 GARS Glycine--tRNA ligase 1 8043700.0 2679200.0 2821200.0 2543300.0 True False 4064542.275756512 2317734.817863794 2040615.6402320082 1.0 0.5702326758140082 0.5020529992770709 21.954661463155237 -13.999999999999998 0.2591369391307464 4.131995835791059 0.4769270070921471 0.9995605773473327 0.004620715030372491 14.379072610724348 0.1610868234680797 23.571081268872575 0.02994326553352745 1.0000000000000041e-14 13.999999999999998 -3.655068828698912 KLK(ub)EDKAPQVDVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLKEDKAPQVDVDK 14 3 P41250 P41250 GARS Glycine--tRNA ligase 1 7073300.0 2679200.0 1992500.0 2401600.0 True False 3468277.214927502 1881615.6234517335 1964533.4424969405 1.0 0.5425216921396132 0.5664291868140089 21.725787785247686 -10.407028063225958 5.917911794916712 1.000137948198021 0.5544754394768128 0.9978449897960362 0.009760193830096988 1.7769600109848993e-05 1.7805029933042092e-06 0.009453159389107 0.003150089013310012 3.917165643624221e-11 10.407028063225958 -0.4456625087212083 KLLAEVTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLLAEVTLK 9 1 K7ER00;Q9Y285;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 5587000.0 1789900.0 1481800.0 2315300.0 False True 1733080.604241724 2073490.467484916 1708853.4724888515 1.0 1.1964189446296019 0.9860207703591072 20.72490732401588 -6.6616110016595025 1.9671429579428004 1.1262605641351393 0.9868934272092702 0.24259562789397715 0.08359777514191308 0.4805642540407813 3.5765084668152247 0.034313910307784405 0.09269182125127978 2.1796612247018452e-07 6.6616110016595025 -0.1393671369258691 KLLAEVTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLLAEVTLK 9 1 K7ER00;Q9Y285;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 52971900.0 5232900.0 22549000.0 25190000.0 False True 7938691.8762340555 18524954.77385887 20211185.45883076 1.0 2.3335021767650104 2.5459087937820946 22.92046987151002 -10.485212480926117 0.3799103373447463 1.5613447652244674e-20 2.572518816938899 0.9992144828554985 0.019176153429267206 1.96010400994916 0.17996834821851374 1.9652808959040544 0.057304581853832186 3.27180580843489e-11 10.485212480926117 2.572518816938899 KLLAEVTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLLAEVTLK 9 1 K7ER00;Q9Y285;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 47065900.0 5232900.0 26727000.0 15106000.0 False True 6774092.205880171 25239618.955078773 12356863.00064907 1.0 3.7259042522583057 1.8241356369378676 22.691596193602468 -9.288371057184422 9.192397912295405 1.0000075627833627 2.7750199445983648 0.5373644094907305 0.7763937860757146 0.0 0.0 0.7517400508865261 0.2505800169621753 5.147886259987396e-10 9.288371057184422 1.775012381815002 KLLASLVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLLASLVKR 9 2 Q13263;Q13263-2;M0R3C0 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 3411990.0 767290.0 1065400.0 1579300.0 True False 742932.7989433118 1490819.7759876016 1165633.9520155676 1.0 2.006668406763067 1.568962837114571 19.502872193927644 -10.146862586080497 4.697639002332868 0.9999226110389237 1.787815621946519 0.8120089937462577 0.17869255056194652 0.00014485167059127133 2.6305859266522623e-05 0.1730351873410965 0.05767277269773592 7.13078617675059e-11 10.146862586080497 0.7878930109075954 KLLASLVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLLASLVKR 9 2 Q13263;Q13263-2;M0R3C0 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 3309290.0 767290.0 1885000.0 657000.0 True False 638035.6317104284 1874845.1308567957 794375.6623752228 1.0 2.9384646212167844 1.2450333851193895 19.28327746936192 -6.613456776426111 2.1410646258767825 2.2920152616203477 1.2512307176309199 0.0614130822089507 0.8349866956428788 0.6029690603717109 5.242939473916134 0.3214985753752563 0.9264597590639769 2.4352481582946003e-07 6.613456776426111 -1.0407845439894279 KLLEEVQLLK(ub)PR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLLEEVQLLKPR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 9625000.0 2738600.0 3740300.0 3146100.0 True False 3590331.1206401284 3182261.8195752054 2820571.7515221816 1.0 0.8863421541486771 0.7856021232435229 21.775685473003808 -6.97254831782024 0.18757830564658107 1.0704747080419075 0.5987243772645513 0.9999960353373096 0.00017428998634511257 0.07548414823192978 0.0059671617101125654 0.0036311262567373715 0.011056540621159008 1.0652503416969323e-07 6.97254831782024 -0.4717503307773562 KLLEEVQLLK(ub)PR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLLEEVQLLKPR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 21982600.0 5014200.0 5599400.0 11369000.0 True False 4855026.965634319 7835269.62048525 8391117.83731084 1.0 1.6138467769481393 1.7283359900380126 22.2110478779612 -11.400947874117048 0.2952022110123326 1.729517963127122e-10 1.7623771517532334 0.9993430388504182 0.008196608304892898 3.6909889575851684 0.15703625809901609 2.4195800161783567 0.042137575429640056 3.972392249606537e-12 11.400947874117048 1.7623771515802815 KLLEEVQLLK(ub)PR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLLEEVQLLKPR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 15471700.0 2738600.0 4866900.0 7866200.0 True False 3751134.4278822476 4651864.265313925 6008365.569474322 1.0 1.2401219830290637 1.6017462676927907 21.8388955345267 -6.965190982666041 0.35476312980591607 0.9669139725756434 1.8872465196316672 0.9999170235191431 0.0022529161518252657 0.077896251502134 0.014632019236243963 0.00490697072663928 0.03098688590212938 1.0834503577900468e-07 6.965190982666041 0.9203325470560239 KLLEEVQLLK(ub)PR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLLEEVQLLKPR 12 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 19174780.0 5014200.0 8020580.0 6140000.0 True False 4169529.466723706 7977371.543579526 7423845.6118475925 1.0 1.9132546267499846 1.7804996153873047 21.991453153395476 -10.261012781429628 5.362652251642274 0.9999077664491577 1.8468771210687185 0.9819036416813387 0.05419700643958402 5.977124389488725e-05 8.23659721284142e-06 0.052481671647324576 0.01749200861286296 5.482608291866544e-11 10.261012781429628 0.8469693546195608 KLLEGEEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLLEGEEER 9 1 Q03252;P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q3BDU5;Q5TCI8;P20700;E9PBF6 Q03252;P02545;P02545-2;P20700 LMNB2;LMNA;LMNB1 Lamin-B2;Prelamin-A/C;Lamin-A/C;Lamin-B1 0 4368630.0 170730.0 2501600.0 1696300.0 False True 223828.68335167214 2128371.0311604277 1520783.1480585735 1.0 9.508928879398367 6.794406888723774 17.772035402072024 -9.255556067876022 9.563743202227593 0.9999558335553731 8.151667884061855 0.9024846183665473 1.1081989624157023 0.0 0.0 1.0730090312962386 0.35766967709874614 5.551929364985202e-10 9.255556067876022 7.1517120505064815 KLLEGEEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLLEGEEER 9 1 Q03252;P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q3BDU5;Q5TCI8;P20700;E9PBF6 Q03252;P02545;P02545-2;P20700 LMNB2;LMNA;LMNB1 Lamin-B2;Prelamin-A/C;Lamin-A/C;Lamin-B1 0 4863910.0 1429900.0 518110.0 2915900.0 False True 1384508.6071876865 724994.0249079568 2152138.3148750667 1.0 0.523647177882568 1.5544419902499884 20.400942591976936 -6.781036978739947 1.5316482193176122 0.7306366244452075 1.5628990144158232 0.7710788872797636 0.20153687943769977 0.2489796780800646 1.1537306864515453 0.10362511098747476 0.24431932135852116 1.6556289861308249e-07 6.781036978739947 0.8322623899706157 KLLEGEEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLLEGEEER 9 1 Q03252;P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q3BDU5;Q5TCI8;P20700;E9PBF6 Q03252;P02545;P02545-2;P20700 LMNB2;LMNA;LMNB1 Lamin-B2;Prelamin-A/C;Lamin-A/C;Lamin-B1 0 4017450.0 170730.0 2240320.0 1606400.0 False True 233853.4948047675 2141335.254652466 1227001.4048465015 1.0 9.156738309342604 5.2468807698207085 17.835245463594916 -9.427512162831157 10.367431318082726 0.9999999792474497 7.201809539581658 0.7703630682705792 1.5961926564670634 0.0 0.0 1.5455068939588765 0.5151689646529588 3.7366966026036554e-10 9.427512162831157 6.201809560334208 KLLEHK(ub)EIDGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLLEHKEIDGR 11 2 A0A087X2I1;P62333;H0YJC0;H0YJS8;H0YJE9;H0YJT1;H0YJD2;H0YJY8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 15499900.0 3455900.0 9360900.0 2683100.0 True False 4473730.675973409 8839957.686107572 2194803.3309308584 1.0 1.975970018397262 0.4905980019580204 22.09304697633967 -6.729421596459746 1.725036382454268 1.587684134571624 0.49151264081625895 0.556787305044159 0.4102913263906008 0.33728579554253324 1.9659761742465263 0.18849234264087214 0.4680916022210853 1.8645687600027286e-07 6.729421596459746 -1.096171493755365 KLLLFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLLLFLK 7 1 E7ETZ4;Q9Y6E2;Q75MG1;B5MCH7;E7EMS9;C9JF98;Q9Y6E2-2;C9J188;C9JWF5;Q7L1Q6-2;Q7L1Q6;Q7L1Q6-4;Q7L1Q6-3;C9IZ80;C9JFN4 E7ETZ4;Q7L1Q6-2 BZW2;BZW1 Basic leucine zipper and W2 domain-containing protein 2;Basic leucine zipper and W2 domain-containing protein 1 0 9583200.0 3282100.0 3522800.0 2778300.0 False True 4302864.883901616 2997211.971766852 2490828.1673354534 1.0 0.6965619541018762 0.5788766867057418 22.036866107638375 -13.999999999994278 0.13106015657080117 2.442272940675664 0.41626423753818437 0.9996408428776217 0.0033621734387664034 11.93520589819683 0.11268350988092375 4.430180985255752 0.14467515752137428 1.0000000000131746e-14 13.999999999994278 -2.02600870313748 KLLLFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLLLFLK 7 1 E7ETZ4;Q9Y6E2;Q75MG1;B5MCH7;E7EMS9;C9JF98;Q9Y6E2-2;C9J188;C9JWF5;Q7L1Q6-2;Q7L1Q6;Q7L1Q6-4;Q7L1Q6-3;C9IZ80;C9JFN4 E7ETZ4;Q7L1Q6-2 BZW2;BZW1 Basic leucine zipper and W2 domain-containing protein 2;Basic leucine zipper and W2 domain-containing protein 1 0 8119600.0 2948700.0 1825000.0 3345900.0 False True 2855095.132536776 2553732.0172492717 2469508.4151515774 1.0 0.8944472596190725 0.8649478565561487 21.44510738669949 -13.999999999999996 0.17884569212680565 1.5457477025577804 0.8412335661593826 0.9994995658859992 0.001296926752345078 12.190009676434233 0.1340516716777921 2.3111859304955806 0.022243299905294174 1.0000000000000082e-14 13.999999999999996 -0.7045141363983978 KLLLFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLLLFLK 7 1 E7ETZ4;Q9Y6E2;Q75MG1;B5MCH7;E7EMS9;C9JF98;Q9Y6E2-2;C9J188;C9JWF5;Q7L1Q6-2;Q7L1Q6;Q7L1Q6-4;Q7L1Q6-3;C9IZ80;C9JFN4 E7ETZ4;Q7L1Q6-2 BZW2;BZW1 Basic leucine zipper and W2 domain-containing protein 2;Basic leucine zipper and W2 domain-containing protein 1 0 13626300.0 3282100.0 4636700.0 5707500.0 False True 4495581.065417484 4431835.262483523 4359506.049652272 1.0 0.9858203417964522 0.9697313842671024 22.100076169161266 -6.969481736971051 0.2702920979574659 1.0039854656231557 0.9510823990741913 0.9999778300337412 5.793505771359203e-05 0.0764714537660559 0.009631061521613894 0.0003148173689606517 0.0014957619887339063 1.0727987604116385e-07 6.969481736971051 -0.05290306654896437 KLLLFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLLLFLK 7 1 E7ETZ4;Q9Y6E2;Q75MG1;B5MCH7;E7EMS9;C9JF98;Q9Y6E2-2;C9J188;C9JWF5;Q7L1Q6-2;Q7L1Q6;Q7L1Q6-4;Q7L1Q6-3;C9IZ80;C9JFN4 E7ETZ4;Q7L1Q6-2 BZW2;BZW1 Basic leucine zipper and W2 domain-containing protein 2;Basic leucine zipper and W2 domain-containing protein 1 0 7116300.0 2948700.0 2038200.0 2129400.0 False True 2451974.6995588886 2027219.8120489756 2574647.6947668195 1.0 0.8267702812813172 1.0500302858875337 21.225512662133767 -6.699569951350368 1.8322938907156938 0.8923872566005954 1.0493633926605375 0.41559815686148494 0.07312800463728758 0.3964116356309652 2.587084082381635 0.03184277197883064 0.08193804264204226 1.997239049364128e-07 6.699569951350368 0.1569761360599421 KLMVALAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLMVALAK 8 1 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 11301900.0 2295500.0 5392200.0 3614200.0 False True 3482441.3235290637 4429919.780549109 2899851.7858398682 1.0 1.2720730570874004 0.8327065746225392 21.73166761404825 -6.739214162537936 1.6895336158648147 1.1620323458422745 0.8324923184401876 0.60138182925075 0.11431622015624494 0.31926271449623983 1.7891180499196284 0.05353287629338722 0.13148039147734242 1.8229965109774783e-07 6.739214162537936 -0.329540027402087 KLMVALAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLMVALAK 8 1 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 4042200.0 0.0 2243700.0 1798500.0 False True 0.0 2144565.9150762996 1373731.3412701904 0.0 KLMVALAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLMVALAK 8 1 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 13677800.0 2295500.0 6093400.0 5288900.0 False True 2971570.001069751 5754296.93347092 4326374.468696737 1.0 1.936450068953247 1.4559221109175495 21.502793936140698 -10.258536422037308 4.9725491565674735 0.999856859921045 1.6961860899358807 0.7367501488204156 0.19617471738983566 0.0003113675343125856 4.642805473590655e-05 0.18998388279526396 0.06331511778290945 5.5139595770876104e-11 10.258536422037308 0.6963292300148357 KLNCQVIGASVDSHFCHLAWVNTPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLNCQVIGASVDSHFCHLAWVNTPK 25 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 615575000.0 95429000.0 266804000.0 253342000.0 False True 144772769.79440427 219190741.6508333 203268842.65625694 1.0 1.514032935628102 1.4040543877479483 27.109215031569214 -10.136314372280449 5.1374803565899505 0.9999832241058081 1.4590436616885947 0.9587271673482024 0.04489855416175476 6410598.199084032 12648192.718206484 850.2072390435754 0.015369968290422848 7.306100261270443e-11 10.136314372280449 0.4590604375827866 KLNCQVIGASVDSHFCHLAWVNTPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLNCQVIGASVDSHFCHLAWVNTPK 25 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 485851000.0 95429000.0 222993000.0 167429000.0 False True 123534721.6868156 210583243.52339908 136958639.96661413 1.0 1.7046482207428961 1.1086651436656874 26.880341353661663 -10.319781678030019 4.077709859521272 0.9993177238436945 1.4066566822060964 0.3830071257229457 0.24330907242388697 173049599.5231205 1193.0785190023812 1112486.6790174334 0.08329116712370443 4.788707625097973e-11 10.319781678030019 0.40733895836240186 KLNVTEQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLNVTEQEK 9 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 0 48614000.0 1795000.0 46819000.0 0.0 False True 2353262.3828047286 39833787.69903265 0.0 1.0 16.92704901506005 0.0 21.166230755703374 -6.585482865403114 2.2469661654050603 9.999999999999998 0.04712809167426934 0.28307839646755595 6.565863040275462 0.5061029158561366 4.812560692332701 2.5832851545618145 7.733461649998411 2.597270211735012e-07 6.585482865403114 -9.95287190832573 KLNVTEQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLNVTEQEK 9 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 0 55604600.0 21232000.0 7512600.0 26860000.0 False True 20558001.78180923 10512420.357691444 19824560.217272297 1.0 0.5113541904152071 0.9643233047491065 24.293196706974186 -10.525342430258357 9.186643648285868 1.000011430324369 0.7378387475821568 0.30873365498686356 0.18492386655974455 4.329407077919363e-05 2.237088657485151e-06 0.17905955778122085 0.05968392129184775 2.9830296476810304e-11 10.525342430258357 -0.26217268274221217 KLNVTEQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLNVTEQEK 9 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 0 66729000.0 1795000.0 33755000.0 31179000.0 False True 2458660.00805106 32263592.487142026 23815162.35166152 1.0 13.122429445914667 9.68623651650779 21.229440817226266 -9.70484864440213 8.65061784011103 0.9999803841464592 11.404332981211265 0.9243797224036332 1.4028198891800934 0.0 0.0 1.3582745171100996 0.4527581723700331 1.9731102632708244e-10 9.70484864440213 10.404352597064806 KLNVTEQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLNVTEQEK 9 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 0 22864380.0 21232000.0 1045800.0 586580.0 False True 17655348.737082228 1040166.0678249521 709231.1659605152 1.0 0.05891506779700421 0.04017089532028834 24.073601982408462 KLNVTEQEK(ub)IDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLNVTEQEKIDK 12 2 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879 P06733 ENO1 Alpha-enolase;Enolase 1 18144000.0 7202500.0 8145700.0 2795800.0 True False 9442547.249109222 6930393.311689914 2506517.4352073106 1.0 0.7339537869237249 0.2654492870495053 23.170744667040193 -7.049235451968735 0.42022261222470125 1.0217537600192534 2.446903356521052e-14 0.9998158774827693 0.004120305569472538 0.07342579476725582 0.01978269129514874 0.0062583322847431936 0.03638590097992804 8.928213110377373e-08 7.049235451968735 -1.021753760019229 down KLNVTEQEK(ub)IDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLNVTEQEKIDK 12 2 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879 P06733 ENO1 Alpha-enolase;Enolase 1 23591200.0 9126200.0 10226000.0 4239000.0 True False 8836493.776429307 14309295.12788552 3128678.7327258894 1.0 1.619340825662607 0.3540633662948316 23.075042606951516 -6.773588041872229 1.560631801902127 1.3535972696632774 0.34594275889622017 0.7441569670065056 0.2612936898494082 0.2606494804371966 1.2533079245688497 0.13193126015473342 0.3130402688461321 1.684270950182506e-07 6.773588041872229 -1.0076545107670571 KLNVTEQEK(ub)IDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLNVTEQEKIDK 12 2 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879 P06733 ENO1 Alpha-enolase;Enolase 1 18664300.0 7202500.0 7947900.0 3513900.0 True False 9865458.890243877 7596735.497809388 2683989.1910421564 1.0 0.7700336682079666 0.27205923423353373 23.233954728563084 -6.958461479448116 0.4566031688885191 1.0150180131334527 0.007114631389435901 0.9997088028815609 0.005184537414420185 0.08025540119013364 0.02319739492269048 0.006724894894739447 0.04115386156914729 1.1003694402690726e-07 6.958461479448116 -1.0079033817440168 down KLNVTEQEK(ub)IDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLNVTEQEKIDK 12 2 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879 P06733 ENO1 Alpha-enolase;Enolase 1 27463000.0 9126200.0 15188000.0 3148800.0 True False 7588839.659210605 15106179.229418056 3807199.521593758 1.0 1.9905782580455007 0.5016840113327398 22.855447882385793 -6.727377391512016 1.7329128378530965 1.59787620689621 0.5030095547373066 0.5469653707290241 0.4165099758952082 0.34120021950503066 2.00611206800829 0.19057003393110766 0.4742754836087972 1.87336589042628e-07 6.727377391512016 -1.0948666521589034 KLNVTEQEKIDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLNVTEQEKIDK 12 2 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879 P06733 ENO1 Alpha-enolase;Enolase 0 6820300.0 1761900.0 1942100.0 3116300.0 False True 2280814.2822412523 1834020.4277568925 2549165.375938214 1.0 0.8041077443423776 1.1176558283532254 21.121117547759553 -6.737809033329854 1.6950646250234958 0.8831479899731984 1.117740847262594 0.5949270945397755 0.08231055546599995 0.3217897451047119 1.8146194391088852 0.03843130897187876 0.09452210629959631 1.8289042396584466e-07 6.737809033329854 0.2345928572893956 KLPHELCTLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLPHELCTLIR 11 1 Q10713;Q10713-2;Q5SXN9 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 10440200.0 1922000.0 4612400.0 3905800.0 False True 2519760.6126744784 3924247.8989943853 3501665.283079156 1.0 1.5573891738982226 1.389681728282308 21.26485524776671 -10.003526107791592 4.5837077712900465 0.99998831765402 1.4735354509066647 0.9140165222008301 0.06846627810057605 23601609.456906628 0.4192598870540014 3192.881104886633 0.023437828070629208 9.9191370814576e-11 10.003526107791592 0.47354713325264475 KLPHELCTLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLPHELCTLIR 11 1 Q10713;Q10713-2;Q5SXN9 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 6919300.0 1922000.0 2128700.0 2868600.0 False True 2632615.340097013 2034646.9953304473 2191095.7606714866 1.0 0.7728614827776054 0.832288609467247 21.328065309289602 -9.904732902716049 11.418003929846893 0.9999984288727299 0.8025750456650741 0.936368321980702 0.024261022895183147 0.0 0.0 0.023490634401088083 0.00783021146702936 1.24528024137252e-10 9.904732902716049 -0.19742338320765584 KLPIDVTEGEVISLGLPFGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLPIDVTEGEVISLGLPFGK 20 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EKJ7;K7ES59;K7ELW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 15346000.0 7390000.0 3109500.0 4846500.0 False True 7155408.495081481 4351139.565828287 3577056.25811654 1.0 0.6080910081959953 0.49990944061060305 22.770602700637504 -13.999999999999927 0.18060936770137062 3.037249853051947 0.41451366232528425 0.9994974155753059 0.004816251120780455 12.21269008077414 0.1347276068087172 8.732313989023714 0.08035592584705452 1.0000000000001677e-14 13.999999999999927 -2.6227361907266626 KLPIDVTEGEVISLGLPFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLPIDVTEGEVISLGLPFGK 20 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EKJ7;K7ES59;K7ELW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 73578900.0 4744800.0 60843000.0 7991100.0 False True 7198208.491344254 49985091.281471275 6411655.5823764475 1.0 6.944101624949826 0.8907293516277521 22.779206458898887 -6.650332218355957 2.0072436442663655 4.8560949767371016 0.9161206342416901 0.1954447059905987 2.536795983316707 0.5077146615680052 3.921299278546188 1.0248081990803144 2.810056841846991 2.2370092589753103e-07 6.650332218355957 -3.9399743424954115 KLPIDVTEGEVISLGLPFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLPIDVTEGEVISLGLPFGK 20 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EKJ7;K7ES59;K7ELW5 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 13815700.0 7390000.0 2392800.0 4032900.0 False True 6145112.432509302 2379909.5114663844 4876160.743977222 1.0 0.3872849419118878 0.7935022829169107 22.55100797607178 -10.094232638834047 5.71902313095144 1.0000027055915333 0.5903936124144189 0.5754930392342048 0.165837535022253 5.720952077755768e-06 9.062143164034501e-07 0.16057256259172978 0.05352383427641388 8.049471390848498e-11 10.094232638834047 -0.40960909317711436 KLPIQEFHLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLPIQEFHLSR 11 1 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 0 94047000.0 18490000.0 26151000.0 49406000.0 False True 24240569.057414725 22249372.735799603 44293941.0558167 1.0 0.917856865616525 1.8272649025237315 24.53092023128452 -6.884846407939533 1.05242612340317 0.9449304377928577 1.8980093935762838 0.9773879855488232 0.06175952568545346 0.12342262882637758 0.2470917169334002 0.044990048048038175 0.11026612123235657 1.3036277363429142e-07 6.884846407939533 0.9530789557834262 KLPIQEFHLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLPIQEFHLSR 11 1 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 0 40618600.0 11442000.0 5214600.0 23962000.0 False True 11078779.973034153 7296816.973779753 17685633.355408773 1.0 0.6586300108441786 1.596352071117556 23.401295680637904 -6.80819503896106 1.4220199988045021 0.8135505396383763 1.6121011662170373 0.8550722833417026 0.14752349660309405 0.20927973666194172 0.8343968010597957 0.08157902027050278 0.18887567431314184 1.5552670139644026e-07 6.80819503896106 0.7985506265786609 KLPIQEFHLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLPIQEFHLSR 11 1 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 0 34343100.0 8369900.0 18382000.0 7591200.0 False True 12697750.221653648 15101588.480778461 6090795.992658848 1.0 1.1893121393288644 0.47967520909902056 23.598069568170732 -6.835735753085028 1.3021043023641605 1.1008277092657803 0.4582446397049987 0.9168605633715532 0.08651035539151714 0.17384002297681328 0.5743783720600028 0.052131259327064645 0.11999428632081238 1.459702147371961e-07 6.835735753085028 -0.6425830695607817 down KLPIQEFHLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLPIQEFHLSR 11 1 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 0 48707000.0 18490000.0 15142000.0 15075000.0 False True 25326252.673461895 14472976.37210204 11514595.479370657 1.0 0.5714614222129887 0.4546505804799232 24.59413029280741 -13.999999999999998 0.1824040402150423 3.2401862132402526 0.36412875495142916 0.9994954352448452 0.005266306991866362 12.236815010300669 0.13540930792467534 9.721042810008715 0.08546560422155602 1.0000000000000041e-14 13.999999999999998 -2.876057458288823 KLPIQEFHLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLPIQEFHLSR 11 1 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 0 28254300.0 11442000.0 9639100.0 7173200.0 False True 9514529.966545535 9587172.255088463 8673082.954870539 1.0 1.0076348793685395 0.911561893794686 23.18170095607218 -6.887675722850204 1.036065985833103 1.0054534322068207 0.9036663795422751 0.9793672280150642 0.006262927595073748 0.12104792161996443 0.23304187599417583 0.0046194817812745415 0.011423837072554066 1.295162546938961e-07 6.887675722850204 -0.10178705266454557 KLPIQEFHLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLPIQEFHLSR 11 1 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 0 25526600.0 8369900.0 9657600.0 7499100.0 False True 10835000.54539479 9120146.07028731 6134340.7472638255 1.0 0.8417300979429718 0.5661597082125769 23.369195890263182 -6.962662092548843 0.39613335208663575 1.0158098458392693 0.3820803959727317 0.999856547474547 0.002147013493772498 0.07876351262827534 0.0177153840958404 0.00354863358613115 0.02312247320242884 1.089777676693253e-07 6.962662092548843 -0.6337294498665376 KLPIVACFHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLPIVACFHLK 11 1 Q9UPT9;Q9UPT9-2;A0A1B0GVA6;Q70EK9 Q9UPT9 USP22;USP51 Ubiquitin carboxyl-terminal hydrolase 22;Ubiquitin carboxyl-terminal hydrolase 51 0 8301900.0 1974900.0 4818100.0 1508900.0 False True 2589113.0249588056 4099258.2608066993 1352773.5023908399 1.0 1.5832674052041127 0.5224853026307584 21.30402651524524 -6.757418299309113 1.6220843891367553 1.339881444085702 0.5190844727412852 0.6803651211032387 0.24524255961002683 0.2872843732048579 1.4891590454552908 0.11932186420057739 0.2874968609918509 1.7481621006231207e-07 6.757418299309113 -0.8207969713444169 KLPIVACFHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLPIVACFHLK 11 1 Q9UPT9;Q9UPT9-2;A0A1B0GVA6;Q70EK9 Q9UPT9 USP22;USP51 Ubiquitin carboxyl-terminal hydrolase 22;Ubiquitin carboxyl-terminal hydrolase 51 0 19308000.0 5185200.0 5498600.0 8624200.0 False True 7866327.488896945 4517331.869242114 6919623.089878852 1.0 0.5742618617923263 0.8796510315195579 22.907258818759413 -9.948852802952475 6.2984140486217575 1.000000065414143 0.7269564466559257 0.5159373113655348 0.12467460646738006 1.1444970295691492e-07 1.913496004220291e-08 0.12071569741650767 0.0402385562119185 1.1249862051249648e-10 9.948852802952475 -0.27304361875821725 KLPIVACFHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLPIVACFHLK 11 1 Q9UPT9;Q9UPT9-2;A0A1B0GVA6;Q70EK9 Q9UPT9 USP22;USP51 Ubiquitin carboxyl-terminal hydrolase 22;Ubiquitin carboxyl-terminal hydrolase 51 0 9641900.0 1974900.0 2752200.0 4914800.0 False True 2705073.8996657585 2630598.7036916665 3754025.4634833047 1.0 0.9724683322022019 1.3877718697249475 21.367236576768132 -6.891052283648704 1.016155737734604 0.9782448611417143 1.4242345099566385 0.9815626433410569 0.025747418437143208 0.11829278886952906 0.2169029455986976 0.019279466631738466 0.0482488586274979 1.2851319367449926e-07 6.891052283648704 0.4459896488149242 KLPIVACFHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLPIVACFHLK 11 1 Q9UPT9;Q9UPT9-2;A0A1B0GVA6;Q70EK9 Q9UPT9 USP22;USP51 Ubiquitin carboxyl-terminal hydrolase 22;Ubiquitin carboxyl-terminal hydrolase 51 0 23369500.0 5185200.0 11299000.0 6885300.0 False True 6712343.6155726 10670200.717380753 5632246.049143978 1.0 1.5896386312264985 0.8390878613659168 22.678385140851862 -6.697221884476224 1.8410862068855864 1.3671387818298608 0.8414546550127997 0.40429552356035836 0.24902282098816472 0.4013116293000692 2.6426782201843513 0.107994861072904 0.278658735059033 2.008066613413363e-07 6.697221884476224 -0.5256841268170611 KLPLGFTFSFPCHQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLPLGFTFSFPCHQTK 16 1 E9PB90;P52789 E9PB90 HK2 Hexokinase;Hexokinase-2 0 64050600.0 17603000.0 33204400.0 13243200.0 False True 23077703.467694487 28250432.94973745 11872920.701744564 1.0 1.2241440310247529 0.5144758324139561 24.459996328376214 -6.821780443954966 1.364109042029686 1.120600370298302 0.49837776184639393 0.8884379118174033 0.09893307690574243 0.19117830579443115 0.6985188403859195 0.05698482917263733 0.13128549913009405 1.5073689186400167e-07 6.821780443954966 -0.6222226084519081 KLPLGFTFSFPCHQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLPLGFTFSFPCHQTK 16 1 E9PB90;P52789 E9PB90 HK2 Hexokinase;Hexokinase-2 0 33882300.0 21478400.0 5517900.0 6886000.0 False True 20796579.948681746 7721226.245468371 5082350.0244280435 1.0 0.3712738471672504 0.2443839341357762 24.30984295715645 -13.999999999999995 0.22497629277765796 4.878900099937543 0.17966410468041083 0.9995033602465666 0.007362633761124968 13.139788042086792 0.1502206688881094 22.704046229187792 0.06798905099489456 1.0000000000000123e-14 13.999999999999995 -4.6992359952571325 KLPLGFTFSFPCHQTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLPLGFTFSFPCHQTK 16 1 E9PB90;P52789 E9PB90 HK2 Hexokinase;Hexokinase-2 0 185845800.0 44172300.0 62462500.0 79211000.0 False True 67012608.52769461 51315578.853259996 63554911.13058542 1.0 0.7657600559162321 0.9484022861805146 25.997929230662656 -9.879447002719221 5.34633579058704 1.000000145961002 0.8570811711840609 0.44946744086759605 0.07456337827712281 1.2974589487481403e-07 2.726561378794089e-08 0.07219575426589048 0.024065226857933854 1.3199363747036258e-10 9.879447002719221 -0.14291897477694104 KLPLGFTFSFPCHQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLPLGFTFSFPCHQTK 16 1 E9PB90;P52789 E9PB90 HK2 Hexokinase;Hexokinase-2 0 94709800.0 17603000.0 29832800.0 47274000.0 False True 24111304.80318818 28514688.252122954 36108854.838591605 1.0 1.1826273395354583 1.4975902438020285 24.523206389899105 -6.9628350216848105 0.39344381166707115 0.9813830969272224 1.710214133164739 0.9998613278412323 0.0024201923798971296 0.07870350373087381 0.017499888113027672 0.004059729055038888 0.02645622224224709 1.0893438309846221e-07 6.9628350216848105 0.7288310362375165 KLPLGFTFSFPCHQTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLPLGFTFSFPCHQTK 16 1 E9PB90;P52789 E9PB90 HK2 Hexokinase;Hexokinase-2 0 133830600.0 44172300.0 51128000.0 38530300.0 False True 57181913.11620713 48282681.85487595 31518180.754263792 1.0 0.8443698229675205 0.5511914351345926 25.769055552755106 -6.961198525008884 0.4182038641640627 1.0132123277268839 0.37132209099629104 0.9998120896482662 0.002550669049095129 0.07927579098661318 0.019570046416018925 0.0037883968076453194 0.02441716718066589 1.093456410422481e-07 6.961198525008884 -0.6418902367305928 KLQATVQELQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLQATVQELQK 11 1 P31146;H3BRY3 P31146 CORO1A Coronin-1A;Coronin 0 8090300.0 1843700.0 3198300.0 3048300.0 False True 2417108.554416196 2721126.1068757526 2732891.157358335 1.0 1.1257773681302394 1.1306447748758268 21.20485083655307 -12.828625310439207 0.4784994823472441 0.02145466230968997 1.1304976545905068 0.9999072611681084 0.0005823221898198692 13.236695379682882 0.23965924509918762 13.29367266887705 0.0010340603489691295 1.483797686350857e-13 12.828625310439207 1.1090429922808167 KLQATVQELQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLQATVQELQK 11 1 P31146;H3BRY3 P31146 CORO1A Coronin-1A;Coronin 0 8029600.0 1843700.0 3313600.0 2872300.0 False True 2525365.714119071 3167194.1953901304 2193921.8968753763 1.0 1.2541526867505406 0.8687541311776646 21.268060898075962 -6.728811746043657 1.7272389983452487 1.1531440231636463 0.8690178737197272 0.5539334757670746 0.10684980118511901 0.3384491596411736 1.9775111936262235 0.049030717501490455 0.1218454450987165 1.8671888872145185e-07 6.728811746043657 -0.2841261494439191 KLQDLYMALQAFSFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLQDLYMALQAFSFK 15 1 Q7Z478;A0A087WYN9;H0Y8L1 Q7Z478 DHX29 ATP-dependent RNA helicase DHX29 0 12386600.0 3473400.0 3719600.0 5193600.0 False True 5269401.739553846 3055808.318632552 4167082.683564252 1.0 0.5799156089570205 0.7908075507480805 22.329207744398555 -10.247152107510145 4.733639848181691 1.0000859207188122 0.6853615798517056 0.7479744834143706 0.08609627471176716 7.809087686920277e-05 1.2419833085467824e-05 0.08338504866698597 0.027787453177011093 5.6604100384059175e-11 10.247152107510145 -0.31472434086710654 KLQDLYMALQAFSFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLQDLYMALQAFSFK 15 1 Q7Z478;A0A087WYN9;H0Y8L1 Q7Z478 DHX29 ATP-dependent RNA helicase DHX29 0 9160700.0 3473400.0 2322800.0 3364500.0 False True 4496384.770949978 2193534.1380946967 2752195.5226852773 1.0 0.48784395683095766 0.6120907490983705 22.100334066491005 -10.03621839460061 7.359321583500377 1.0000000363467223 0.5499673529647184 0.9459245554482192 0.05072354053879018 3.02617032800315e-08 3.977750921198802e-09 0.04911286060102691 0.01637095231395091 9.199868196587647e-11 10.03621839460061 -0.45003268338200386 KLQFLFELPSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLQFLFELPSR 11 1 Q9UID3;Q9UID3-2;E9PKX7;E9PJ36;E9PRV0;E9PMB6 Q9UID3 VPS51 Vacuolar protein sorting-associated protein 51 homolog 0 8980900.0 1676400.0 3038600.0 4265900.0 False True 2543221.3612564285 2496338.08930984 3422742.9951896053 1.0 0.9815653986472389 1.3458297603707867 21.27822560857914 -6.894980681487264 0.9924272448869527 0.9826999347000918 1.3803995435232936 0.9839002199780985 0.021258284966147817 0.11519590205649922 0.1989742278263518 0.016204610188588903 0.04119530127765147 1.2735597309021806e-07 6.894980681487264 0.3976996088232019 KLQFLFELPSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLQFLFELPSR 11 1 Q9UID3;Q9UID3-2;E9PKX7;E9PJ36;E9PRV0;E9PMB6 Q9UID3 VPS51 Vacuolar protein sorting-associated protein 51 homolog 0 1009300.0 293670.0 0.0 715630.0 False True 402247.73513334495 0.0 546612.9328624883 1.0 0.0 1.358896235130538 18.617724772275302 -6.709507250662049 1.7969177260924003 0.38491829850033354 1.3556649059457395 0.46279569081406613 0.42142623556686276 0.3760594344404546 2.3666846400391965 0.18665488027365168 0.47448240973787204 1.9520581436406188e-07 6.709507250662049 0.970746607445406 KLQFLFELPSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLQFLFELPSR 11 1 Q9UID3;Q9UID3-2;E9PKX7;E9PJ36;E9PRV0;E9PMB6 Q9UID3 VPS51 Vacuolar protein sorting-associated protein 51 homolog 0 7520100.0 1676400.0 3807200.0 2036500.0 False True 2170132.8467842904 3595325.9732022253 1665877.8962545888 1.0 1.656730821124518 0.7676386718550857 21.04935193067159 -6.708799536691523 1.7992686704972847 1.4042289976504512 0.7697796041193942 0.4595149443323734 0.2767942887763038 0.37748405849941674 2.381388575650093 0.1224512834823969 0.3115625824452501 1.9552417554857416e-07 6.708799536691523 -0.634449393531057 KLQFSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLQFSLK 7 1 P20290;P20290-2 P20290;P20290-2 BTF3 Transcription factor BTF3 0 34689700.0 7447000.0 9739700.0 17503000.0 False True 9763089.11685058 8286574.725053245 15691957.460631484 1.0 0.8487656545868307 1.6072738118868535 23.218906269205252 -6.854866584403402 1.2112709807698134 0.9188172903965633 1.6405835156357145 0.9471014183850238 0.07538957332205501 0.1521880686347501 0.42722533189906703 0.04863268343151892 0.11295435747069116 1.3967973923791413e-07 6.854866584403402 0.7217662252391511 KLQFSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLQFSLK 7 1 P20290;P20290-2 P20290;P20290-2 BTF3 Transcription factor BTF3 0 23652700.0 9899700.0 3702000.0 10051000.0 False True 9585439.442321815 5180227.905674969 7418341.576463294 1.0 0.5404267521427477 0.7739177344034631 23.192413142764376 -10.491763016827358 7.379994799000085 1.0000608536847193 0.6571722432731131 0.741896956812041 0.09532229434666524 9.54594550847362e-05 6.5739963210354794e-06 0.09231169882506125 0.03076513821057632 3.222826924159353e-11 10.491763016827358 -0.34288861041160623 KLQFSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLQFSLK 7 1 P20290;P20290-2 P20290;P20290-2 BTF3 Transcription factor BTF3 0 37770000.0 11810000.0 12427000.0 13533000.0 False True 17916633.426651407 10209304.75740583 10858196.618275387 1.0 0.5698227180458608 0.6060400053797812 24.094796241620404 -10.04342398012047 5.968500638530495 1.0000008047202515 0.587931362419392 0.9942396994713513 0.014785645639418627 1.5832712668964252e-07 2.5377033073677252e-08 0.014316167775141315 0.004772046610350378 9.048488106406612e-11 10.04342398012047 -0.4120694423008595 KLQFSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLQFSLK 7 1 P20290;P20290-2 P20290;P20290-2 BTF3 Transcription factor BTF3 0 31405000.0 7447000.0 10419000.0 13539000.0 False True 10200357.14760792 9958654.128974458 10341367.044457665 1.0 0.9763044553111413 1.0138240156505511 23.282116330728144 -6.7360162062651145 1.701163052429009 0.9858364596195941 1.0138278825124851 0.5869431413523112 0.009957277701905378 0.3250905266353167 1.845627792941224 0.004633364496679709 0.011420490289243634 1.8364698118030426e-07 6.7360162062651145 0.027991422892891027 KLQFSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLQFSLK 7 1 P20290;P20290-2 P20290;P20290-2 BTF3 Transcription factor BTF3 0 19103800.0 9899700.0 5085600.0 4118500.0 False True 8232039.18107069 5058202.863387438 4979659.308207543 1.0 0.6144532055943821 0.6049120028070456 22.972818418198653 KLQFSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLQFSLK 7 1 P20290;P20290-2 P20290;P20290-2 BTF3 Transcription factor BTF3 0 63495000.0 11810000.0 34007000.0 17678000.0 False True 15288277.809903642 32114480.555444438 14460785.39159764 1.0 2.100595041165519 0.9458740592894016 23.865922563712854 -6.657055870170603 1.9832751346235256 1.7101592857505667 0.9507118408903253 0.22313242342971962 0.4689424355677338 0.4915055181247655 3.713248317516708 0.19123557725486243 0.5197120258321302 2.202643083996027e-07 6.657055870170603 -0.7594474448602414 KLQIGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLQIGVK 7 1 A0A494C1N0;P26885 A0A494C1N0 FKBP2 Peptidyl-prolyl cis-trans isomerase FKBP2 0 13266200.0 4508800.0 2951400.0 5806000.0 False True 5911080.463281318 2511062.6244670944 5205250.815084636 1.0 0.42480602997462347 0.8805921095845028 22.494990428415235 -9.970666483689223 6.899046340877252 1.000000027497063 0.652699069779573 0.4363517251278395 0.18607388781796302 7.875768219348218e-08 1.1674100776321632e-08 0.18016528059408182 0.06005508905691929 1.0698761748974159e-10 9.970666483689223 -0.34730095771749003 KLQIGVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLQIGVK 7 1 A0A494C1N0;P26885 A0A494C1N0 FKBP2 Peptidyl-prolyl cis-trans isomerase FKBP2 0 9445400.0 2609300.0 1481300.0 5354800.0 False True 2526469.1997586098 2072790.814877452 3952217.2394433995 1.0 0.8204298770297678 1.5643243305008476 21.26869116146038 -6.842944854083201 1.2686157041314454 0.9044786622746558 1.5902585137759917 0.9294072238803732 0.08421003113860114 0.16538470418949716 0.5157505992396677 0.052022792255507 0.11996429908743188 1.4356717207421744e-07 6.842944854083201 0.6857798515013359 KLQIGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLQIGVK 7 1 A0A494C1N0;P26885 A0A494C1N0 FKBP2 Peptidyl-prolyl cis-trans isomerase FKBP2 0 12025000.0 4508800.0 3322600.0 4193600.0 False True 6175825.20573851 3175796.5456311074 3203158.0499030673 1.0 0.514230315760911 0.5186607365322982 22.558200489938127 -9.95808335178584 5.211732878545149 1.000001795784165 0.5164455261430778 0.9999370439473869 0.0018087117182673665 3.773941953579953e-08 7.545871924225616e-09 0.0017512840825060962 0.0005837591951389384 1.101327917358901e-10 9.95808335178584 -0.4835562696410871 KLSLLCIDFNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLSLLCIDFNK 11 1 P52888;K7EP46;K7EKB6 P52888 THOP1 Thimet oligopeptidase 0 17795300.0 3003900.0 7748300.0 7043100.0 False True 4557135.914506196 6365555.327255782 5651028.197899612 1.0 1.396832450617296 1.2400394247429305 22.11969596825048 -10.197145419703219 5.334756236603872 0.999983404566722 1.3184359376801837 0.8461438675609207 0.06401048477011298 1.2635109933620411e-05 1.9013802112552007e-06 0.061981112545814954 0.020659295124740233 6.351182324664167e-11 10.197145419703219 0.3184525331134618 KLSLLCIDFNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLSLLCIDFNK 11 1 P52888;K7EP46;K7EKB6 P52888 THOP1 Thimet oligopeptidase 0 7068080.0 912580.0 2280700.0 3874800.0 False True 1249985.487547207 2179931.1327336626 2959652.044010973 1.0 1.743965153556501 2.367749124686697 20.253479914479364 -6.973157454319912 0.16627751918573866 0.42045076022682126 3.7079100659822783 0.9999977011957569 0.0008476759694675103 0.07529083122744516 0.005166167051597963 0.02720966935221031 0.07319276200458558 1.063757281005969e-07 6.973157454319912 3.287459305755457 KLSTIALALGVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLSTIALALGVER 13 1 P30153;C9J9C1;E9PPI5;E9PNM7;E9PHZ6;P30154;P30154-2;P30154-4;P30154-5 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 0 24058300.0 2557100.0 9878200.0 11623000.0 False True 3879307.649050832 8115358.031271138 9325708.95545813 1.0 2.0919604128991316 2.4039622012809154 21.887367762868145 -10.340263173373163 0.2777999879231252 8.591615318358374e-13 2.531006941226792 0.9990546262058728 0.01850737184518181 1.8707153012606041 0.13261546616176756 1.4801103198083452 0.12304231511067999 4.5681128763842484e-11 10.340263173373163 2.531006941225933 KLSTIALALGVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLSTIALALGVER 13 1 P30153;C9J9C1;E9PPI5;E9PNM7;E9PHZ6;P30154;P30154-2;P30154-4;P30154-5 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 0 17484000.0 2557100.0 7189200.0 7737700.0 False True 3310216.3579766816 6789114.700185296 6329517.995506576 1.0 2.050957993674781 1.9121161008869512 21.658494084960594 -10.208842047942197 5.242665626013123 0.9999301558403989 1.9815370472811675 0.9852150465176034 0.05668196537645203 4.627634974062605e-05 6.983441109002442e-06 0.054885943215155046 0.01829402566095686 6.182412123797136e-11 10.208842047942197 0.9816068914407686 KLTLLPAVVMHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLTLLPAVVMHLK 13 1 Q96ST2-2;Q96ST2-3;Q96ST2 Q96ST2-2 IWS1 Protein IWS1 homolog 0 26104300.0 5116600.0 6521700.0 14466000.0 False True 7762256.273565167 5357851.680725327 11606788.75932695 1.0 0.6902441109773475 1.4952854363820183 22.88804463430765 -6.8023733152288095 1.446031979104972 0.8296075984058907 1.5070851419139173 0.8390746438233163 0.13300424576735356 0.21737510414772793 0.897070082401747 0.07234889340348097 0.168032516340144 1.576255753378144e-07 6.8023733152288095 0.6774775435080266 KLTLLPAVVMHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLTLLPAVVMHLK 13 1 Q96ST2-2;Q96ST2-3;Q96ST2 Q96ST2-2 IWS1 Protein IWS1 homolog 0 33408600.0 5116600.0 17721000.0 10571000.0 False True 6623539.563264436 16734810.771989034 8647186.467619574 1.0 2.526566137659065 1.3055234871063073 22.6591709564001 -6.590426290841734 2.226812377956584 2.0328985982068515 1.3090450078328006 0.0 0.661430954033794 0.6682651813480783 6.2476017644136705 0.2478769007550138 0.737340832232004 2.567873994830089e-07 6.590426290841734 -0.7238535903740508 KLVAIVDPHIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLVAIVDPHIK 11 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 9924800.0 4025200.0 3501000.0 2398600.0 False True 5277076.180092252 2978664.4467911115 2150415.8809958664 1.0 0.5644535619986141 0.40750139046851386 22.33130737981143 -13.999999999999998 0.14205446373698896 3.084616767084371 0.21798977128265248 0.9995948713668713 0.005044855341886185 11.936652754237526 0.11823241241696363 6.890032207197394 0.1696655944227432 1.0000000000000041e-14 13.999999999999998 -2.8666269958017185 KLVAIVDPHIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLVAIVDPHIK 11 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 6326460.0 2449100.0 744160.0 3133200.0 False True 2371354.6610695636 1041306.9687431339 2312520.9260148057 1.0 0.4391190342964001 0.9751898203922724 21.177280018521866 -10.783558220076708 10.23914240787686 1.001780165806956 0.7071544273443364 0.28464023558470786 0.21884998199125907 0.008931839602510263 0.00018880688906070214 0.21281409096954507 0.07063352796416163 1.6460452881692555e-11 10.783558220076708 -0.29462573846261964 KLVAIVDPHIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLVAIVDPHIK 11 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 35522700.0 6746300.0 20719000.0 8057400.0 False True 10234630.32059426 17021532.571714126 6464851.35831613 1.0 1.663131157503869 0.6316643743650876 23.28695565672651 -6.733122335044298 1.7121536883793302 1.3976800480525888 0.6319536369554312 0.5735645588970815 0.27870169902869857 0.3304054413662864 1.8989563473594588 0.12893089254401865 0.3187709407191004 1.8487477776877095e-07 6.733122335044298 -0.7657264110971577 KLVAIVDPHIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLVAIVDPHIK 11 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 13371400.0 4025200.0 5212600.0 4133600.0 False True 5513425.216939904 4982290.096236901 3157328.8141642814 1.0 0.9036651265222391 0.5726619460555016 22.394517441334322 -6.94836735799733 0.5764881610234469 1.004010890779799 0.45604267955985117 0.9990668606390195 0.005590717794123141 0.084148009631056 0.03872705314054902 0.0058801100019134885 0.02762459922139435 1.1262443933689545e-07 6.94836735799733 -0.547968211219948 KLVAIVDPHIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLVAIVDPHIK 11 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 5433900.0 2449100.0 1853500.0 1131300.0 False True 2036535.1635261907 1843514.8276090547 1367849.5994598 1.0 0.9052212113131757 0.6716552819502588 20.957685293956143 -6.955768963783769 0.49144929741101234 1.0050449147021896 0.5619029619657097 0.9995796715954127 0.002828847896007466 0.08124861542629172 0.02699060715776718 0.0033734061027107707 0.019263882583606264 1.1072126429209352e-07 6.955768963783769 -0.44314195273647994 KLVAIVDPHIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLVAIVDPHIK 11 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 30185300.0 6746300.0 12847000.0 10592000.0 False True 8733218.339454088 12132053.156579373 8664364.683097778 1.0 1.3891846837002069 0.9921158897350304 23.058081978818958 -6.650730822136943 2.005656328320081 1.252390897698765 0.9937754874054132 0.19714466484225657 0.16607737351687454 0.5067291162316833 3.9078962274534086 0.06713143816873737 0.18398973206371247 2.2349570310277076e-07 6.650730822136943 -0.2586154102933518 KLVIIEGDLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLVIIEGDLER 11 1 J3KN67;A0A2R2Y2Q3;P06753;P06753-7;A0A494C0P6;P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 9986800.0 3732700.0 4382200.0 1871900.0 False True 4893605.847518225 3728392.8416818115 1678213.7445327148 1.0 0.7618907116462297 0.342940113451069 22.22246647443362 -6.962470994276356 0.3990858317671542 1.0232637477175621 0.06629219232086843 0.9998511486878064 0.003313751418151053 0.07882997577563704 0.017954506112659644 0.005391362193353077 0.035113230308037216 1.0902573062186483e-07 6.962470994276356 -0.9569715553966937 down KLVIIEGDLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLVIIEGDLER 11 1 J3KN67;A0A2R2Y2Q3;P06753;P06753-7;A0A494C0P6;P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 9438410.0 4753800.0 885310.0 3799300.0 False True 4602893.221098559 1238818.8998306603 2804149.3534431416 1.0 0.26913917840896495 0.6092145132955927 22.134109544326034 -10.593670362010082 6.521660833674013 1.001255688306603 0.4391768458544648 0.7838354150025779 0.1388351740963915 0.0025395562302937425 0.00015822589145942257 0.13467952660518906 0.044808859761927625 2.548764080278777e-11 10.593670362010082 -0.5620788424521382 KLVIIEGDLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLVIIEGDLER 11 1 J3KN67;A0A2R2Y2Q3;P06753;P06753-7;A0A494C0P6;P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 99082700.0 8969000.0 72398000.0 17715700.0 False True 13606628.721730419 59478011.25184414 14214184.12993285 1.0 4.371252605493305 1.0446514284050492 23.6978063226091 -6.643127376114168 2.0334467203649615 3.1994313438086626 1.058661609729836 0.1665410424927033 1.4413533736790483 0.5255759587769309 4.157340928194437 0.5765030621889905 1.595843538079704 2.2744302554130005e-07 6.643127376114168 -2.1407697340788268 KLVIIEGDLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLVIIEGDLER 11 1 J3KN67;A0A2R2Y2Q3;P06753;P06753-7;A0A494C0P6;P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 14481400.0 3732700.0 6409600.0 4339100.0 False True 5112780.0624246225 6126402.678287225 3314293.946569632 1.0 1.1982527320727179 0.6482371441962441 22.28567653595651 -6.8091816654187305 1.4177720854419196 1.1081494806191585 0.6387746151207345 0.8577460199666561 0.08578236998094893 0.20790625566758253 0.8237830690860856 0.04757576810077666 0.11010403654402223 1.5517377821352308e-07 6.8091816654187305 -0.469374865498424 KLVIIEGDLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLVIIEGDLER 11 1 J3KN67;A0A2R2Y2Q3;P06753;P06753-7;A0A494C0P6;P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 39525000.0 8969000.0 21508500.0 9047500.0 False True 11610547.3054213 20311533.067508943 7400947.835189489 1.0 1.7494035839313882 0.6374331580160543 23.46893264470155 -6.725153642656152 1.7406250690195457 1.4534149960252989 0.6386324386695706 0.536676117319432 0.31517214878872446 0.34545376820400225 2.0480747065055227 0.14361596836761173 0.3583828033774026 1.8829828188494598e-07 6.725153642656152 -0.8147825573557282 KLVLILNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLVLILNK 8 1 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 15158900.0 3985800.0 3430600.0 7742500.0 False True 5225422.398542103 2918767.852374065 6941380.3713043025 1.0 0.5585707010381407 1.328386461779808 22.317116231905466 -6.7511738373472445 1.645326391383685 0.7408049979409563 1.3300711428504712 0.6540819901460663 0.1855038686651207 0.2979999174606974 1.5875351053038502 0.0890479930724248 0.21593346187611803 1.7734794588028012e-07 6.7511738373472445 0.5892661449095149 KLVLILNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLVLILNK 8 1 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 7737600.0 3029500.0 1610300.0 3097800.0 False True 2933330.180764458 2253301.187603565 2286393.2479920387 1.0 0.7681716849946738 0.7794530813425782 21.484108041830932 -9.820524457875468 6.084718675067462 1.0000000150553892 0.7738123831705422 0.998137739258723 0.004605610773849922 9.405310852977381e-10 1.8565277686823521e-10 0.004459363722017189 0.0014864544854062036 1.5117345616067726e-10 9.820524457875468 -0.22618763188484692 KLVLILNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLVLILNK 8 1 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 55923900.0 8938900.0 26083000.0 20902000.0 False True 13560964.821125668 21428284.862590853 16770710.538327947 1.0 1.580144565319515 1.2366900703261205 23.69295648967222 -10.289098023999552 5.147414147817659 0.9999105053116747 1.4084173178228967 0.6534302716668613 0.1402147104334576 0.0001440376285490371 1.9892943387601353e-05 0.13579190316356074 0.04525410320013351 5.139276406022555e-11 10.289098023999552 0.408506812511222 KLVLILNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLVLILNK 8 1 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 10945800.0 3985800.0 2900900.0 4059100.0 False True 5459457.972194932 2772728.646006523 3100424.1797886174 1.0 0.507876177475503 0.5678996331832034 22.380326293428357 -10.204088179013452 5.393452132784004 1.0000235523923213 0.53788790532999 0.9875046689953436 0.024504473180646483 6.9401613712550296e-06 1.0241537392905781e-06 0.023727561238129517 0.007908784711317165 6.250457707965543e-11 10.204088179013452 -0.46213564706233135 KLVLILNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLVLILNK 8 1 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 6449300.0 3029500.0 1748800.0 1671000.0 False True 2519163.4796058093 1739378.8672903778 2020398.3741689473 1.0 0.6904589088289539 0.8020116163660378 21.26451331726521 -10.381002440953635 5.077231213707687 1.0001826575151789 0.7462352625974715 0.8734156732729721 0.04554120214871427 9.42282977915362e-05 1.1487907590357346e-05 0.044126616050616185 0.014698359790674203 4.159082728735691e-11 10.381002440953635 -0.25394739491770735 KLVLILNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLVLILNK 8 1 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 56667900.0 8938900.0 30065000.0 17664000.0 False True 11571582.262061605 28391856.320740934 14449333.247945515 1.0 2.45358462462182 1.2486912265506556 23.46408281176467 -6.599973830730931 2.1911694213684463 1.9776100631409843 1.2526309048251698 0.0203296941987976 0.6282955399979301 0.640813535565478 5.814771829788353 0.23804485444030074 0.6987485184339622 2.5120377947323463e-07 6.599973830730931 -0.7249791583158145 KLVYLYLMNYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLVYLYLMNYAK 12 1 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 6277340.0 1387800.0 741040.0 4148500.0 False True 1343745.048643314 1036941.1364725499 3061883.397667692 1.0 0.7716799682495405 2.2786192966880607 20.357828008073977 -6.8682919798276725 1.1431627906037765 0.8721251051637445 2.3640288497694004 0.9629448934591629 0.1276536341145747 0.13849934300555894 0.33935326465933036 0.08675277035695476 0.20479311642451872 1.354278613330568e-07 6.8682919798276725 1.491903744605656 up KLVYLYLMNYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLVYLYLMNYAK 12 1 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 30584700.0 8330800.0 4771900.0 17482000.0 False True 12638432.663060753 3920317.16197513 14026675.037367197 1.0 0.3101901372179891 1.1098429220866888 23.591314225081543 -6.67847606120662 1.907139406790239 0.5629503036774706 1.1067741217619174 0.3171781964189252 0.29245656530549036 0.4419490938227608 3.106464444727449 0.12310307951018237 0.32533072766338134 2.0966403462474673e-07 6.67847606120662 0.5438238180844468 KLVYLYLMNYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLVYLYLMNYAK 12 1 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 10397910.0 541610.0 4013500.0 5842800.0 False True 741857.8534599076 3836170.2991303406 4462850.976243234 1.0 5.171031460055386 6.015776412461234 19.500783254606038 -9.523778933616523 0.469694448675431 4.236963026923192e-18 6.038162677030021 0.9983674173712251 0.08859420463707145 0.8468953306986576 0.1998367124453846 1.6571509098262325 0.1808483853553262 2.9937881593208505e-10 9.523778933616523 6.038162677030021 KLVYLYLMNYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLVYLYLMNYAK 12 1 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 3174000.0 1387800.0 0.0 1786200.0 False True 1154017.1899643329 0.0 2159686.1615443276 1.0 0.0 1.8714505991120263 20.138233283508253 -6.761545516790197 1.6064186357567116 0.4202415427880449 1.8788609189939711 0.6972597662148796 0.4207063480967781 0.2803680825438444 1.4262723282189933 0.2065878518895199 0.4957548868073503 1.7316275357945193e-07 6.761545516790197 1.4586193762059263 KLVYLYLMNYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLVYLYLMNYAK 12 1 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 33087800.0 8330800.0 17383400.0 7373600.0 False True 10784384.824618561 16415998.508763308 6031680.459525091 1.0 1.5222007352045632 0.5592975916211733 23.362440547173993 -6.759428572363102 1.6147069269973595 1.303536866884424 0.5558880160025175 0.6886165864258147 0.2196203698064909 0.2838687063503279 1.4586001504343888 0.1073237659558558 0.2580528233139924 1.7400888638091214e-07 6.759428572363102 -0.7476488508819066 KLVYVYLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLVYVYLVR 9 1 O00203;O00203-3;Q13367-4;A0A590UJ60;Q13367;A0A2R8Y2A8;A0A590UKC4;A0A5F9UJV3;A0A590UJW5;F5GWU4;A0A590UJ44;A0A590UK69;F5GYB0 O00203 AP3B1;AP3B2 AP-3 complex subunit beta-1;AP-3 complex subunit beta-2 0 9866400.0 3905600.0 2769100.0 3191700.0 False True 5120279.421884201 2355961.073867259 2861453.5009482685 1.0 0.460123536187854 0.5588471380523387 22.28779111188675 -9.930287205286138 5.492295159303609 1.0000005407249433 0.5094853371221938 0.9705149744455999 0.04030374169467418 3.2271628581805854e-07 6.278459664498063e-08 0.0390239824235711 0.013007976697042132 1.1741208348770882e-10 9.930287205286138 -0.49051520360274947 KLVYVYLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLVYVYLVR 9 1 O00203;O00203-3;Q13367-4;A0A590UJ60;Q13367;A0A2R8Y2A8;A0A590UKC4;A0A5F9UJV3;A0A590UJW5;F5GWU4;A0A590UJ44;A0A590UK69;F5GYB0 O00203 AP3B1;AP3B2 AP-3 complex subunit beta-1;AP-3 complex subunit beta-2 0 7541000.0 3683900.0 1643700.0 2213400.0 False True 3566956.6109649064 2300037.9817822617 1633644.139423326 1.0 0.6448180431216607 0.4579938355295566 21.76626223606064 -12.233196156640219 0.09700600073416969 2.3165975234361897 1.1312588865842161e-17 0.9998629131546668 0.002632081172525585 6.24358109679462 0.07364631241311853 2.018798754564057 0.3486222046885945 5.845260131941628e-13 12.233196156640219 -2.3165975234361897 KLVYVYLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLVYVYLVR 9 1 O00203;O00203-3;Q13367-4;A0A590UJ60;Q13367;A0A2R8Y2A8;A0A590UKC4;A0A5F9UJV3;A0A590UJW5;F5GWU4;A0A590UJ44;A0A590UK69;F5GYB0 O00203 AP3B1;AP3B2 AP-3 complex subunit beta-1;AP-3 complex subunit beta-2 0 25777500.0 5783200.0 7995300.0 11999000.0 False True 8773537.208552955 6568476.247435976 9627392.390651463 1.0 0.7486691047520312 1.0973216573659845 23.064727177603526 -6.713322870996121 1.7838073455660861 0.8460107120821093 1.0965694180421233 0.48068286449871944 0.10585629624593405 0.36842626692392283 2.287323032079312 0.047193385257905736 0.11939272551160997 1.934982889383267e-07 6.713322870996121 0.25055870596001395 KLVYVYLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KLVYVYLVR 9 1 O00203;O00203-3;Q13367-4;A0A590UJ60;Q13367;A0A2R8Y2A8;A0A590UKC4;A0A5F9UJV3;A0A590UJW5;F5GWU4;A0A590UJ44;A0A590UK69;F5GYB0 O00203 AP3B1;AP3B2 AP-3 complex subunit beta-1;AP-3 complex subunit beta-2 0 14981300.0 3905600.0 2786000.0 8289700.0 False True 5349605.864871428 2662905.307930016 6331843.591730608 1.0 0.4977759811084729 1.1836093633194762 22.351001173409642 -6.710403057949806 1.7936084563002095 0.6913739125165599 1.1820284581012943 0.4670818158364082 0.2116209157245933 0.374270021638103 2.347282602213755 0.09388022893001596 0.2383976575645017 1.9480358367527248e-07 6.710403057949806 0.4906545455847344 KLVYVYLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KLVYVYLVR 9 1 O00203;O00203-3;Q13367-4;A0A590UJ60;Q13367;A0A2R8Y2A8;A0A590UKC4;A0A5F9UJV3;A0A590UJW5;F5GWU4;A0A590UJ44;A0A590UK69;F5GYB0 O00203 AP3B1;AP3B2 AP-3 complex subunit beta-1;AP-3 complex subunit beta-2 0 8125400.0 3683900.0 1382300.0 3059200.0 False True 3063326.074441273 1374853.275534933 3698864.5758573576 1.0 0.4488106202620612 1.2074668141660374 21.546667511494917 -6.711884825147963 1.788654337127753 0.6617854181496429 1.2057697931670541 0.4739219328800047 0.2322021205336066 0.3713262648708154 2.3169432889272654 0.10326776778808057 0.26173428798092485 1.941400668586601e-07 6.711884825147963 0.5439843750174113 KLVYVYLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLVYVYLVR 9 1 O00203;O00203-3;Q13367-4;A0A590UJ60;Q13367;A0A2R8Y2A8;A0A590UKC4;A0A5F9UJV3;A0A590UJW5;F5GWU4;A0A590UJ44;A0A590UK69;F5GYB0 O00203 AP3B1;AP3B2 AP-3 complex subunit beta-1;AP-3 complex subunit beta-2 0 31488200.0 5783200.0 13732000.0 11973000.0 False True 7486466.403914879 12967802.128601855 9794036.853354387 1.0 1.732165941707911 1.3082322587105735 22.835853499695975 -10.230341951301947 4.553186414663136 0.999841839170755 1.52019910021084 0.6675114782127674 0.17307020138968543 0.0002861824941087366 4.8375471731830705e-05 0.16762645983288602 0.05585816730364634 5.883801988466945e-11 10.230341951301947 0.520357261040085 KLYCIYVAIGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLYCIYVAIGQK 12 1 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 9241400.0 5295600.0 2758800.0 1187000.0 False True 5127494.076664891 3860403.2269519386 876089.0907633008 1.0 0.752883020288711 0.17086106344819826 22.289822489413773 -7.1470529077309966 0.5511327937324617 1.0056989284048774 1.0077954993039813e-20 0.9989499754642778 0.011262911112328088 0.08117733745561687 0.040429153114905365 0.01186340723710502 0.04703788153233765 7.127661924145759e-08 7.1470529077309966 -1.0056989284048774 down KLYCIYVAIGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KLYCIYVAIGQK 12 1 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 236298000.0 42917000.0 73391000.0 119990000.0 False True 65108226.65297183 60293802.64349975 96273923.90651481 1.0 0.9260550585238166 1.4786752589600818 25.956336508702254 -6.8731624957750785 1.1171813081160238 0.9572587026565089 1.5130527994748344 0.967741212718593 0.043994095141368116 0.13386123498401792 0.3103304652461978 0.030498205907393505 0.07263220081486298 1.3391755272914966e-07 6.8731624957750785 0.5557940968183255 KLYDIDVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLYDIDVAK 9 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9;K7EMA7 P62750 RPL23A 60S ribosomal protein L23a 0 5438710.0 2552900.0 677710.0 2208100.0 False True 2471859.586886811 948323.1372109626 1629732.368419919 1.0 0.38364765629965664 0.6593142980554526 21.237165363110346 -10.426109685813609 6.076036849840707 1.0001559267081739 0.5214809771775891 0.8007022740646587 0.11254043523471821 0.00023778846107086636 2.245935376438924e-05 0.10900179244432534 0.036322269286583116 3.74878310677511e-11 10.426109685813609 -0.47867494953058476 KLYGAQFHPEVGLTENGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLYGAQFHPEVGLTENGK 18 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 12028100.0 3524000.0 2915000.0 5589100.0 False True 4619998.126464541 2480093.3625810076 5010793.546432918 1.0 0.5368169628412602 1.0845877875425534 22.139460835913372 -6.682562073676428 1.8925860726096067 0.70762098132738 1.082557177858557 0.3359940637492783 0.19619796423572342 0.4328465520640415 2.9996666711520397 0.08311255056696289 0.21850280540375439 2.0770068379306427e-07 6.682562073676428 0.37493619653117694 KLYVSNLGIGHTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLYVSNLGIGHTR 13 1 Q06203;D6RCC8 Q06203 PPAT Amidophosphoribosyltransferase 0 7248500.0 1384100.0 1957500.0 3906900.0 False True 1791744.7346898904 1848563.4042192062 3195884.2881792528 1.0 1.0317113640292905 1.783671650488978 20.77293368427047 -6.915758944136941 0.8555882007769257 0.980739562991828 1.893844918219123 0.9929193951373341 0.030476400816115298 0.10073221817907055 0.11901990451965949 0.025684901519255104 0.07407799665838122 1.214062530878985e-07 6.915758944136941 0.9131053552272951 KLYYQQLK(ub)MK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KLYYQQLKMK 10 2 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 7026700.0 2311500.0 2529200.0 2186000.0 True False 3030398.884597843 2151853.218744383 1959813.689592665 1.0 0.7100891007059457 0.6467180606333768 21.5310762742289 -13.99999999999312 0.21368571855566945 2.7025811703890157 0.6106994578558748 0.9994923981096288 0.0034649692296652517 12.835504915229206 0.14649049092389219 9.191678478651832 0.03659156794185351 1.0000000000158414e-14 13.99999999999312 -2.091881712533141 KLYYQQLK(ub)MK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KLYYQQLKMK 10 2 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 12408600.0 5114100.0 3950700.0 3343800.0 True False 4951755.694816813 5528235.112628324 2467958.468150231 1.0 1.1164191962085153 0.49840069265402875 22.239508707266754 -6.857981153365223 1.1959244626184582 1.0628542057183588 0.4696109288479726 0.9511373845944205 0.05927253808245141 0.14889404997160602 0.40581106127736316 0.03868706354057592 0.09011000983369323 1.386816009806301e-07 6.857981153365223 -0.5932432768703861 down KLYYQQLK(ub)MK ddPTM_RPMI8226_Bortezomib_8h_R1 2 KLYYQQLKMK 10 2 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 58201600.0 21247800.0 17090000.0 19863800.0 True False 32234466.02225261 14040155.97522053 15937711.223387165 1.0 0.43556347313239513 0.49443075037708983 24.94210074903455 -10.123760666325962 5.76114746316932 1.0000047886386187 0.46499711175892383 0.9910014769139182 0.024032465299535923 1.478159260242561e-06 2.247985305769234e-07 0.023269542764003222 0.00775644482276566 7.52037217138571e-11 10.123760666325962 -0.535007676879695 KLYYQQLK(ub)MK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 KLYYQQLKMK 10 2 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 9860930.0 2940560.0 3547460.0 3372910.0 True False 4027764.497646031 3390721.487318523 2576298.1252619624 1.0 0.8418370759512334 0.6396347469589254 21.94154790112697 -6.967776842659659 0.3066750613051375 1.0323997151736273 0.44267545641157224 0.9999594793917083 0.0009388049676696938 0.07703086344858212 0.011598786450788184 0.003248486759858664 0.01801051606233842 1.0770184853201006e-07 6.967776842659659 -0.589724258762055 KLYYQQLK(ub)MK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 KLYYQQLKMK 10 2 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 19419500.0 6120200.0 9604400.0 3694900.0 True False 5089217.470831315 9552659.190875852 4467486.506712651 1.0 1.8770389054165222 0.8778336811735605 22.279012410744684 -6.674873980912377 1.9202399975374567 1.5574455369195455 0.8817849999144652 0.3007991028313576 0.37213328326979245 0.4499919353270029 3.2034157374018997 0.15576704497645957 0.4135216970689042 2.114102399244212e-07 6.674873980912377 -0.6756605370050802 KLYYQQLK(ub)MK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KLYYQQLKMK 10 2 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 47195500.0 16381000.0 22072000.0 8742500.0 True False 21205527.417784173 20843673.79715264 7151454.705625206 1.0 0.982935882069688 0.3372448402121602 24.337937029888593 -6.912570185630103 0.8780574615600327 1.0184039000861214 0.24904706563283802 0.99185562302225 0.027839364190755073 0.10274295051790912 0.12973284294203954 0.023086101854892974 0.06492146900343199 1.223009454494701e-07 6.912570185630103 -0.7693568344532833 down KMCLFAGFQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KMCLFAGFQR 10 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 26874000.0 13134000.0 5873300.0 7866700.0 False True 17218801.189836923 4997026.533944086 7052729.346714843 1.0 0.2902075747813087 0.4095946790347742 24.03748136689506 -9.98682525556294 5.911053597902762 1.0000006668822787 0.3499011269215549 0.9753300158832874 0.04873958121538654 4.2833029379534713e-07 7.35211009954866e-08 0.0471919444014421 0.01573063219562306 1.0308007940757553e-10 9.98682525556294 -0.6500995399607239 KMCLFAGFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KMCLFAGFQR 10 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 13094200.0 6810200.0 1877000.0 4407000.0 False True 6594013.928715019 2626495.88842569 3252674.4928339175 1.0 0.39831518659493 0.4932768611041999 22.652725503779678 -10.807396423090617 7.28318561266644 1.0219231036416665 0.44579602384956524 0.978454364832533 0.03876794127799523 0.012638183411021258 0.00033421595596881904 0.03437518255741434 0.012512299244701883 1.5581295960909698e-11 10.807396423090617 -0.5761270797921012 KMCLFAGFQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KMCLFAGFQR 10 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 246629000.0 49348000.0 63461000.0 133820000.0 False True 74864523.82204859 52135888.726943836 107370418.34461035 1.0 0.696403130151068 1.4341962369229462 26.157778892498087 -6.794965899477385 1.4763295729929118 0.8314034005203034 1.4431631491064136 0.8170227764601312 0.129513111580821 0.22803884805307642 0.981672516574413 0.06903076473439801 0.1610606398204005 1.6033712814264475e-07 6.794965899477385 0.6117597485861103 KMCLFAGFQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KMCLFAGFQR 10 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 35950200.0 13134000.0 13982000.0 8834200.0 False True 17989994.733004235 13364229.007709058 6747743.906060111 1.0 0.7428700900724111 0.37508315072937615 24.100691428417953 -6.966035475909869 0.33981585974129486 1.0399769603733982 0.0657571896593421 0.9999329224927707 0.0021003478817440526 0.07761135938438403 0.013630840285015135 0.005194745995155507 0.03183782114982916 1.0813456165663564e-07 6.966035475909869 -0.9742197707140561 down KMCLFAGFQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KMCLFAGFQR 10 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 318128000.0 49348000.0 126240000.0 142540000.0 False True 63881958.79450678 119214633.02612132 116599182.58390832 1.0 1.8661705945743887 1.825228668378508 25.928905214590536 -10.100779160513204 4.534142943595631 0.9999318952665859 1.8456996315079017 0.9982453000733629 0.01671447155310233 5817807.082753881 0.6142446993444433 4300.2043261031895 0.005721808164587451 7.929044212398742e-11 10.100779160513204 0.8457677362413158 KMDADGFLPITLIASFHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KMDADGFLPITLIASFHR 18 1 Q6PKG0-3;Q6PKG0;A0A0B4J210;E5RH50;H0YBW1;H0YC73 Q6PKG0-3 LARP1 La-related protein 1 0 18346700.0 4412900.0 7994000.0 5939800.0 False True 6694691.926204053 6567408.242592916 4765795.926493178 1.0 0.9809873725312245 0.7118768091238254 22.674586237007606 -6.921150475974718 0.816156656291787 1.0056951461910792 0.667311941288083 0.9944943952097341 0.009762491299808131 0.0974996028018398 0.10214380136121938 0.00846302107569199 0.025636102272056756 1.1990837681414245e-07 6.921150475974718 -0.3383832049029962 KMDADGFLPITLIASFHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KMDADGFLPITLIASFHR 18 1 Q6PKG0-3;Q6PKG0;A0A0B4J210;E5RH50;H0YBW1;H0YC73 Q6PKG0-3 LARP1 La-related protein 1 0 21440100.0 4412900.0 6363200.0 10664000.0 False True 5712586.041263647 6009082.326297653 8723261.421880163 1.0 1.051902287841676 1.5270249513739564 22.445712559100055 -6.927677471789632 0.7656047491176493 0.9921188885711102 1.6190400435798808 0.9960620983712122 0.014882237185066661 0.0938612066194762 0.08371680381173513 0.013375784177494215 0.043552079207599646 1.1811975247474421e-07 6.927677471789632 0.6269211550087707 KMDETDASSAVK(ub)VK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KMDETDASSAVKVK 14 2 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 3560500.0 994600.0 1009600.0 1556300.0 True False 963026.9674165157 1412738.5449944483 1148658.3420007792 1.0 1.4669771385367958 1.1927582309374487 19.877216672519392 -10.240092672461852 4.883813706798041 0.9999358688727464 1.3298676847375124 0.6586337951473977 0.11194940024184732 79007340.54905748 6.488007892009118 56981.8169690869 0.03832325738203815 5.7531715947882015e-11 10.240092672461852 0.32993181586476594 KMDETDASSAVK(ub)VK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KMDETDASSAVKVK 14 2 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 2922900.0 994600.0 1374200.0 554100.0 True False 827053.9682508471 1366796.9118426566 669959.7481310674 1.0 1.6526090972434635 0.8100556600290288 19.65762194795367 -6.699946095632165 1.831452799129646 1.405271674960204 0.8125958856553696 0.4171811873455834 0.2754773806597341 0.395614400551508 2.5798919758406953 0.12001034780922124 0.3086106733371541 1.9955099810877e-07 6.699946095632165 -0.5926757893048346 KMK(ub)DTDSEEEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KMKDTDSEEEIR 12 2 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 1 1295450.0 423260.0 489250.0 382940.0 True False 579750.6601714155 467633.3172666044 292497.4588968621 1.0 0.8066110992065774 0.5045228561022752 19.14507303212911 -6.964574501099661 0.3652807326674741 1.0245099521252496 0.27618623485333027 0.9999041038583549 0.001996653913890561 0.07810563835188764 0.015370825892247185 0.004012661547692451 0.0257229909591211 1.0849894090274922e-07 6.964574501099661 -0.7483237172719194 KMNLGVGAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KMNLGVGAYR 10 1 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 14356000.0 5117800.0 4180600.0 5057600.0 False True 6709485.360845702 3556870.775851167 4534288.067924923 1.0 0.530125722698177 0.6758026620619075 22.67777068063341 -10.855122160063974 10.894432580827054 1.0104825711000738 0.6029641923800457 0.9082916550785309 0.059472361455250804 0.014537193771149542 0.00019332017839229185 0.055283002568769536 0.019194622122984523 1.3959756402940953e-11 10.855122160063974 -0.40751837872002805 KMNLGVGAYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KMNLGVGAYR 10 1 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 9164150.0 2722600.0 934450.0 5507100.0 False True 2636172.553275893 1307580.7580923752 4064625.300541339 1.0 0.4960148592957178 1.5418661784830248 21.330013375788454 -6.775671628771829 1.552649203830211 0.7130187416331607 1.5490628047291446 0.7517675247983249 0.212774001198569 0.2573793468199798 1.2251854281743426 0.1079676592661454 0.2557045354811227 1.6762097837447085e-07 6.775671628771829 0.8360440630959839 KMNLGVGAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KMNLGVGAYR 10 1 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 10617200.0 5117800.0 2063200.0 3436200.0 False True 7009988.963344686 1972041.0019099794 2624640.3307604254 1.0 0.28131870281419913 0.37441433138977825 22.740980742156303 -10.739615227373733 6.98933258715808 1.0101751250232545 0.32786651710198866 0.9858158090976606 0.038006131215638936 0.005957356590780175 0.000221938661184998 0.03637993336230364 0.012266426104328616 1.8213137764919302e-11 10.739615227373733 -0.6823086079212658 KMNLGVGAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KMNLGVGAYR 10 1 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 6267200.0 2722600.0 1680000.0 1864600.0 False True 2263962.5316305594 1670949.50654611 2254479.239063683 1.0 0.7380641168750494 0.9958111972109157 21.11041865122273 -10.812830492224723 9.383933100400418 1.0023316802966347 0.8669376570637731 0.2621855334925792 0.1052248049191694 0.005209837806431034 0.00010391386665728678 0.10340793159091546 0.03396115975498894 1.5387551085813264e-11 10.812830492224723 -0.13539402323286154 KMNLGVGAYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KMNLGVGAYR 10 1 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 6611600.0 2510400.0 4101200.0 0.0 False True 3249762.287382054 3872964.6147554587 0.0 1.0 1.1917685886728178 0.0 21.631902761509068 -6.918916731415469 1.2611808068505281 1.1009677890928458 7.750953586184178e-16 0.958579889531205 0.10633951805517278 0.12291322406222267 0.3912972740541958 0.06932514037224248 0.13552468720130878 1.2052670076804138e-07 6.918916731415469 -1.100967789092845 down KNELEQK(ub)MLLNLHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KNELEQKMLLNLHK 14 2 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 69654600.0 5230600.0 19727000.0 44697000.0 True False 7935202.608081521 16206562.72224551 35862618.358608924 1.0 2.042362813236818 4.519433230612792 22.919835628924364 -6.956539524796976 0.48174192035433605 0.9415071043066534 5.723867575927095 0.9996195145413735 0.028792101808513514 0.08096137302762832 0.02588172876690226 0.0350503120871537 0.20432562582184235 1.1052498768891993e-07 6.956539524796976 4.782360471620441 KNELEQK(ub)MLLNLHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KNELEQKMLLNLHK 14 2 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 55677600.0 5230600.0 21491000.0 28956000.0 True False 6771114.810540382 20295006.957892716 23686305.113649845 1.0 2.9972918087727765 3.498139638214097 22.690961951016813 -9.842302074764604 0.35552237420291616 1.8983148823238428e-25 3.6010313924833417 0.9987090865594634 0.03877242458258557 1.1901117369441503 0.15480612114189407 1.4487278166179465 0.14489732284122844 1.4377981657644544e-10 9.842302074764604 3.6010313924833417 KNENSFEK(ub)QVSCHENSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KNENSFEKQVSCHENSK 17 2 A0A0A0MTP7;Q99590;A0A087WUE7 A0A0A0MTP7 SCAF11 Protein SCAF11 1 11254900.0 1737100.0 2575300.0 6942500.0 True False 2635307.6990208407 2115717.5940892617 5570311.831994159 1.0 0.8028351280859405 2.1137235071501634 21.32953999036488 -6.868598641056607 1.1415526928529942 0.8893927848914078 2.188455672754915 0.963260806425117 0.11062068970940948 0.13820189893601362 0.33748454627767277 0.07527014724377769 0.1777754249555929 1.3533226763580059e-07 6.868598641056607 1.2990628878635073 up KNEPIIK(ub)VSDHSNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KNEPIIKVSDHSNR 14 2 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-5;H0Y9T9;E9PKR7;Q9NQW1;Q9NQW1-2;Q9NQW1-5;Q9NQW1-4 D6REX3 SEC31A;SEC31B Protein transport protein Sec31A;Protein transport protein Sec31B 1 2063580.0 485730.0 578480.0 999370.0 True False 470310.76702515944 809470.0807333473 737605.0165426449 1.0 1.7211387395050737 1.5683353821733503 18.843254835244217 -10.108673738235641 4.8509870913859645 0.9999694107278538 1.6447370608437148 0.9595758318898551 0.06238170942334507 2.0638516036078812e-05 3.7921997796418545e-06 0.06040368900861274 0.020133610139836056 7.786212670833194e-11 10.108673738235641 0.644767650115861 KNEPIIK(ub)VSDHSNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KNEPIIKVSDHSNR 14 2 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-5;H0Y9T9;E9PKR7;Q9NQW1;Q9NQW1-2;Q9NQW1-5;Q9NQW1-4 D6REX3 SEC31A;SEC31B Protein transport protein Sec31A;Protein transport protein Sec31B 1 2226590.0 485730.0 1175700.0 565160.0 True False 403906.01648751606 1169366.2707418217 683332.3429954044 1.0 2.895144471753529 1.6918102605597727 18.623660110678493 -10.109105628104563 4.76522632869071 0.9999405568379295 2.293477366163034 0.6063888833966309 0.4912591346908428 171133551.22160628 20.82350090640363 138062.33446615326 0.16817106851382188 7.778473417905981e-11 10.109105628104563 1.2935368093251043 KNFATSLYSMIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KNFATSLYSMIK 12 1 P08758;D6RBL5;D6RBE9 P08758 ANXA5 Annexin A5;Annexin 0 15976500.0 7133600.0 4301600.0 4541300.0 False True 5931904.4720633775 4278426.426999252 5490864.833401213 1.0 0.7212567982422393 0.9256495716107257 22.500063934009816 -10.323153911650184 5.589789652051617 1.0000290690781952 0.8234531854521233 0.49869180992526974 0.08344300031085979 3.0233726046149553e-05 3.660898194015213e-06 0.08080663013972582 0.02693111254679394 4.751667995181016e-11 10.323153911650184 -0.1765758836260719 KNFEVVDLVDVNTPDLMAPVSAKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KNFEVVDLVDVNTPDLMAPVSAKK 24 2 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 10197900.0 1716000.0 2989000.0 5492900.0 True False 1426930.0316895775 2972897.6637299517 6641439.993699935 1.0 2.0834221704688973 4.654355747097172 20.444483164537814 -6.956569888506294 0.4813552011160808 0.939070496004019 5.906140635857543 0.999621036595518 0.02983372354412733 0.08095009803169054 0.025838413630715807 0.036349643513473494 0.21207051504065882 1.105172606018268e-07 6.956569888506294 4.967070139853524 KNGFVVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KNGFVVLK 8 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 55458000.0 13361000.0 23372000.0 18725000.0 False True 17516400.38810806 19884988.703342445 16787516.62288322 1.0 1.1352211791666071 0.958388495976623 24.062202996468933 -6.702377281449113 1.822545760527349 1.0837726155210425 0.958893569965148 0.4287569427573791 0.05705437794015138 0.3906193110179138 2.5241979626750872 0.024959644629937227 0.0639982674992672 1.9843703009514202e-07 6.702377281449113 -0.12487904555589457 KNGFVVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KNGFVVLK 8 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 45514200.0 18434000.0 4554200.0 22526000.0 False True 17848822.760261454 6372715.809839255 16625764.834485354 1.0 0.35703843863738977 0.9314768294691619 24.0893255869846 -10.542156160042218 9.1142217253518 1.0000238916044617 0.6442576340532875 0.3383423383342753 0.23451349103388336 0.00011385799948364226 5.719708850721701e-06 0.22708190448799978 0.07568890376959941 2.869748515887566e-11 10.542156160042218 -0.3557662575511742 KNGFVVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KNGFVVLK 8 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 58327700.0 6410400.0 46762000.0 5155300.0 False True 9725045.463014908 38416955.74682638 4136352.695351736 1.0 3.950311172624231 0.42532990833642903 23.213273563804787 -6.684643500729072 1.8853899081886552 2.8588059759216713 0.43817651258412704 0.34560284754005566 1.2491513447113523 0.42822423991757347 2.9468805908057423 0.5308662798152831 1.3918497653040691 2.0670762602720632e-07 6.684643500729072 -2.4206294633375443 KNGFVVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KNGFVVLK 8 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 43526000.0 13361000.0 12963000.0 17202000.0 False True 18300922.76744858 12390251.797091462 13139241.886310706 1.0 0.6770288009263505 0.7179551574132188 24.125413057991825 -10.587524021507921 9.769749000080733 1.0000282455551395 0.6974919792649817 0.9864583235159412 0.0167081150706786 1.0280232108978081e-05 4.340203942263568e-07 0.016179066805709404 0.0053925209512712775 2.5850918501291287e-11 10.587524021507921 -0.30253626629015773 KNGFVVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KNGFVVLK 8 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 29671900.0 18434000.0 6756600.0 4481300.0 False True 15328687.764665302 6720200.8547199 5418319.110809877 1.0 0.43840679371204044 0.3534757308645711 23.869730862418876 -13.999999999999993 0.2659566164471862 5.242011055919779 0.3241605512620142 0.9995747102103908 0.005915767075360458 14.688778133690867 0.16322269659927785 33.60818464035327 0.036001283894745106 1.0000000000000164e-14 13.999999999999993 -4.917850504657765 KNGFVVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KNGFVVLK 8 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 24818400.0 6410400.0 9170200.0 9237800.0 False True 8298389.167875208 8659870.308746342 7556615.187832378 1.0 1.0435603987181636 0.9106122929357915 22.984399885897236 -6.818460698439267 1.3786580842541765 1.0235160351922248 0.9078079640402666 0.8807672161622379 0.019109036192770476 0.195496806884385 0.7305701770382823 0.010893477586367451 0.025116938252001328 1.5189353921561138e-07 6.818460698439267 -0.11570807115195814 KNGGLGHMNIALLSDLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KNGGLGHMNIALLSDLTK 18 1 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 40751300.0 4824300.0 15341000.0 20586000.0 False True 7318815.803572762 12603278.690219926 16517168.076835675 1.0 1.7220379674082649 2.2568088226475975 22.80317880628714 -7.18485130287251 0.12039992139687025 2.1888689691028985e-12 3.8802053148526086 0.9999988943499138 0.0005414755498674427 0.09042857896494345 0.005159294835200536 0.05720788655646989 0.10453819524188683 6.533542148608262e-08 7.18485130287251 3.8802053148504196 KNGGLGHMNIALLSDLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KNGGLGHMNIALLSDLTK 18 1 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 36356300.0 4824300.0 18323000.0 13209000.0 False True 6245151.451170033 17303308.9427885 10805097.535785353 1.0 2.770678834305406 1.730157806462966 22.57430512837959 -10.121914457791709 4.696881524486561 0.9999197380968435 2.2504183203952346 0.6581802373921041 0.424790930936795 0.0004178358971453447 7.811538675854374e-05 0.411332502945994 0.1371006834093364 7.552409714810663e-11 10.121914457791709 1.2504985822983912 KNICQFLVEIGLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KNICQFLVEIGLAK 14 1 P41567;K7EM18 P41567 EIF1 Eukaryotic translation initiation factor 1 0 21936400.0 3921800.0 7522600.0 10492000.0 False True 5949657.3219848825 6180133.255657931 8418251.601193028 1.0 1.0387376820546295 1.4149136909257474 22.5043751462977 -6.9266774038056935 0.773564025183226 0.9935204686466037 1.4859922535984955 0.9958443718174027 0.012063246855206534 0.09439948119220583 0.08639900252027741 0.010780411039010217 0.034679842079811805 1.1839206515885191e-07 6.9266774038056935 0.4924717849518918 KNICQFLVEIGLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KNICQFLVEIGLAK 14 1 P41567;K7EM18 P41567 EIF1 Eukaryotic translation initiation factor 1 0 2191700.0 1860000.0 331700.0 0.0 False True 1546672.4119712196 329913.06626270496 0.0 1.0 0.213305069456973 0.0 20.560736233033662 -9.347142185109629 0.45555114666018653 1.1762645024229255 7.075347611886889e-25 0.9973845273611647 0.02199282935490512 0.783288572657769 0.20664197635898088 0.29228536912411257 0.04777890833406168 4.496326240785866e-10 9.347142185109629 -1.1762645024229255 KNICQFLVEIGLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KNICQFLVEIGLAK 14 1 P41567;K7EM18 P41567 EIF1 Eukaryotic translation initiation factor 1 0 15338300.0 3921800.0 6289300.0 5127200.0 False True 5076847.4102354 5939294.92626097 4194102.2095146263 1.0 1.169878557761416 0.8261233538472956 22.27550146839015 -6.77231333518401 1.5654445037939646 1.0971479549923138 0.8240109410094463 0.7394006076581157 0.07164240320592367 0.26269651990613924 1.2707838182794422 0.03606509429887152 0.08567442045115096 1.6892217506190642e-07 6.77231333518401 -0.2731370139828675 KNIFLLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KNIFLLFK 8 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 19551300.0 4591300.0 6537700.0 8422300.0 False True 6019238.762212445 5562300.643755 7550841.188406357 1.0 0.9240870587613156 1.254451183396977 22.52114961387999 -6.8462454657624505 1.2529692086222157 0.9595823469624605 1.2667384456053357 0.9346692949682185 0.03611181962795097 0.16164262036363353 0.49021271943857464 0.022571618714559667 0.05212514139144383 1.4248020595816747e-07 6.8462454657624505 0.3071560986428752 KNIFLLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KNIFLLFK 8 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 15092100.0 5896900.0 2706600.0 6488600.0 False True 5709706.1372998655 3787359.49473254 4789041.00617249 1.0 0.6633195130640457 0.8387543756213766 22.44498506532037 -10.111704481547418 4.758432272219261 1.0000147652488893 0.7510369443400655 0.7286443545577986 0.07162098273588559 99824335.12881625 0.3115054819633552 16149.438133230105 0.024517767395589106 7.732065394565364e-11 10.111704481547418 -0.2489778209088238 KNIFLLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KNIFLLFK 8 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 15565100.0 4591300.0 4002600.0 6971200.0 False True 6288827.68521717 3825751.897171819 5324746.136370723 1.0 0.6083410277188579 0.8466993218604694 22.584359675402883 -10.32065570534709 5.847903961929743 1.000029013101664 0.7275201747896628 0.6353553802207763 0.09730936610119849 3.6812649418548234e-05 4.27641576923364e-06 0.09422940697273083 0.03140646286166141 4.779079935571742e-11 10.32065570534709 -0.27250883831200123 KNIFLLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KNIFLLFK 8 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 12661300.0 5896900.0 2426100.0 4338300.0 False True 4903533.6269640215 2413030.117756855 5245418.471967173 1.0 0.4921002487854582 1.0697221373425814 22.225390340754647 -6.674529240441273 1.9215655819619375 0.6770713699785753 1.0674250734382853 0.29911842881470363 0.21552393445632997 0.45082236431577877 3.2134738674847774 0.09016354413099946 0.23945897388633314 2.115781227848434e-07 6.674529240441273 0.39035370345971 KNILLTIGSYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KNILLTIGSYK 11 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 111132000.0 41965000.0 28680000.0 40487000.0 False True 55016521.3896381 24401055.79376437 36297793.618727475 1.0 0.4435223307004667 0.6597616988842165 25.71336158735215 -10.197265985524322 5.425411061072005 1.0000197907798443 0.5516420147922817 0.8514594741080148 0.08827935239222127 2.113373093491552e-05 3.1268681077127135e-06 0.08547988284864594 0.0284920384690556 6.349419398206211e-11 10.197265985524322 -0.44837777598756257 KNILLTIGSYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KNILLTIGSYK 11 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 56415100.0 16035000.0 7734100.0 32646000.0 False True 15525977.702115221 10822366.4627987 24095033.240992986 1.0 0.6970489505034061 1.5519172900596359 23.888180784933 -6.810948154845383 1.4108999332590169 0.8350814019895768 1.5671477437309882 0.8621967187880936 0.1313734049241981 0.20551629417663358 0.8061931908759457 0.07321742398018619 0.169267145458436 1.5454389197489293e-07 6.810948154845383 0.7320663417414114 KNILLTIGSYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KNILLTIGSYK 11 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 95326000.0 26314000.0 24686000.0 44326000.0 False True 39920261.81108427 20280590.42740167 35564946.671224065 1.0 0.5080274904853093 0.8908996348653478 25.25061784661803 -9.84353617371874 6.411137306932107 1.0000000115784056 0.6994635626752778 0.45101212349667796 0.15630689840957016 2.5774206558556888e-08 4.9246670988762355e-09 0.15134350811970115 0.050447834536439265 1.433718292290626e-10 9.84353617371874 -0.3005364489031278 KNILLTIGSYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KNILLTIGSYK 11 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 98694000.0 41965000.0 22868000.0 33861000.0 False True 57480594.5614834 21857616.14563662 25863729.18918535 1.0 0.38026078735592916 0.4499558396446393 25.77657164887504 -10.355913687456148 5.812273897030705 1.000105552709664 0.4151083135027665 0.9894630753891293 0.02845288595066031 3.892429819738922e-05 4.313406770187207e-06 0.027554304492056793 0.009183129453203156 4.406424289521973e-11 10.355913687456148 -0.5849972392068976 KNILLTIGSYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KNILLTIGSYK 11 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 41840000.0 16035000.0 11289000.0 14516000.0 False True 13333812.970945412 11228183.916308947 17551228.485599272 1.0 0.84208350160418 1.3162947855833642 23.668586060367275 -6.816925797145178 1.3849624502131876 0.9146045367283345 1.3259916481766667 0.877171420169583 0.06909925132831744 0.19752866710889128 0.7452755499226724 0.039212785317527254 0.09046859851328547 1.5243131732398633e-07 6.816925797145178 0.4113871114483322 KNILLTIGSYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KNILLTIGSYK 11 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 93506000.0 26314000.0 36153000.0 31039000.0 False True 34063991.72648641 34141053.768958874 25390220.48703473 1.0 1.0022622728155652 0.7453683259115109 25.02174416871048 -6.904912172125251 0.9296771696307596 1.0092894842984237 0.7155418610165348 0.9888560355911994 0.012728103382612701 0.10787972029824153 0.15772434709744437 0.010165331669960649 0.027164146850568407 1.2447663168493656e-07 6.904912172125251 -0.29374762328188886 KNMQITILTCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KNMQITILTCR 11 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 0 19315200.0 7696500.0 7403000.0 4215700.0 False True 10090186.033012025 6298501.25666798 3779499.8038498624 1.0 0.62422052834915 0.37457186532383907 23.266449437905532 -8.299251655783923 0.1752193754400352 1.3359053093775426 1.9559655232559064e-07 0.9998573656810448 0.003069991294021933 0.09300788782834254 0.038349001438605104 0.1260441166111763 0.12575006897916724 5.0205158697997015e-09 8.299251655783923 -1.3359051137809903 down KNMQITILTCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KNMQITILTCR 11 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 0 20657400.0 7696500.0 8668600.0 4292300.0 False True 10542104.04009191 8285592.588773203 3278547.1426933724 1.0 0.7859524585664179 0.31099552140872144 23.329659499428423 -6.957963775004508 0.46324324494819236 1.0134047610391053 0.06429242270917002 0.9996870517984446 0.005093557967578551 0.08043673510465352 0.023881152897270573 0.006486752882537955 0.039223079918762026 1.1016311940170862e-07 6.957963775004508 -0.9491123383299352 down KNNIK(ub)LYVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KNNIKLYVR 9 2 P08238;Q58FF7;P07900;P07900-2 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1 Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha 1 2412250.0 745210.0 985180.0 681860.0 True False 976977.5266239048 838194.9842015632 611307.6680629719 1.0 0.8579470472550931 0.6257131319851736 19.897965850754172 -6.963787237587216 0.3782890283666188 1.016262302173065 0.4592077395099401 0.9998859208324056 0.001647749955502352 0.07837493677806533 0.016326024380118577 0.0030278377556057527 0.019639810739103772 1.0869579977931341e-07 6.963787237587216 -0.5570545626631249 KNNIK(ub)LYVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KNNIKLYVR 9 2 P08238;Q58FF7;P07900;P07900-2 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1 Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha 1 3037850.0 567160.0 849490.0 1621200.0 True False 549155.8162476885 1188695.7870318263 1196559.0850425134 1.0 2.164587448338493 2.178906331573521 19.066856028828216 -10.906495864435067 0.7532362897638076 1.5349793850804976e-14 2.1760835836509242 0.9999816270630475 0.0023677719574082897 2.8210737449852976 0.39325192113778906 4.978854253061264 0.002135356420342206 1.2402354351923913e-11 10.906495864435067 2.1760835836509087 KNNIK(ub)LYVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KNNIKLYVR 9 2 P08238;Q58FF7;P07900;P07900-2 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1 Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha 1 2315300.0 745210.0 618020.0 952070.0 True False 1020734.275543024 590713.8328811581 727210.6744971419 1.0 0.5787146048043721 0.7124387726769247 19.961175912277064 -10.850879268203988 10.769624982102934 1.0087810797254184 0.6455766887406492 0.9035326457155735 0.05459266292767223 0.011261717684724368 0.00015593413575455475 0.05171774992867218 0.017619706195332475 1.4096806284517274e-11 10.850879268203988 -0.3632043909847692 KNNIK(ub)LYVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KNNIKLYVR 9 2 P08238;Q58FF7;P07900;P07900-2 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1 Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha 1 3342770.0 567160.0 2134000.0 641610.0 True False 471618.6694481705 2122503.718434165 775767.684530543 1.0 4.500465855004542 1.6449045272916143 18.847261304262492 -6.595655023437947 2.2067033093706026 3.360619354887016 1.6536336901929733 0.008438931020626983 1.514656776887334 0.6530714356877486 6.003327054260099 0.5710735841465128 1.6867168542303295 2.537143179233413e-07 6.595655023437947 -1.7069856646940427 KNPLK(ub)NLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KNPLKNLR 8 2 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 15346700.0 4172300.0 4796300.0 6378100.0 True False 4039852.62030155 6711487.602374074 4707484.27110144 1.0 1.661319912673721 1.165261387864703 21.945871231648162 -10.257947562894103 5.315942353448634 0.9999530597864402 1.4132906502692573 0.4806587664513432 0.20251504472347495 0.00011267733340042666 1.5728378214345733e-05 0.19610655031857108 0.06536144963084815 5.52144101631095e-11 10.257947562894103 0.41333759048281704 KNPLK(ub)NLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KNPLKNLR 8 2 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 7785800.0 3327200.0 0.0 4458600.0 True False 5047605.650902167 0.0 3577355.7557261963 1.0 0.0 0.7087233043030629 22.26716777209488 -10.56593838188752 8.645123109252648 1.0001141492837526 0.35436165432326117 0.5252860908565977 0.2893350773936256 0.0006366815899978229 3.196690561047265e-05 0.28019556381942134 0.09338249468492878 2.716824707158237e-11 10.56593838188752 -0.6457524949604915 KNPLK(ub)NLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KNPLKNLR 8 2 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 7745700.0 2417600.0 0.0 5328100.0 True False 3311452.0531834234 0.0 4069712.5156639963 1.0 0.0 1.228981259671759 21.65903253879332 -6.690350541438017 1.8653668152266842 0.3732520932121902 1.2247252177537606 0.37193683836284896 0.42290233315773773 0.4159386419975981 2.806380025728639 0.18135654198812734 0.4720222475985578 2.0400906177566277e-07 6.690350541438017 0.8514731245415704 KNPLK(ub)NLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KNPLKNLR 8 2 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 20669100.0 4172300.0 9251700.0 7245100.0 True False 3469452.3142298446 9201859.255781328 8760016.912442511 1.0 2.6522512553466164 2.52489906735815 21.72627650708244 -10.161747701952468 4.710683535727403 0.9998212415960088 2.5885751613647816 0.9952029943533932 0.051991313075651635 3220338.6751282797 6946837.119531109 3847.220048725018 0.01779800929243118 6.890524766700867e-11 10.161747701952468 1.5887539197687728 KNPLK(ub)NLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KNPLKNLR 8 2 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 10236900.0 3327200.0 3111700.0 3798000.0 True False 4307125.98891714 2938531.159595864 3106802.970770892 1.0 0.6822487122868314 0.7213169474877555 22.03829409418733 -10.378362515406968 8.844548763870932 1.0000009471736797 0.7017828300116836 0.9872916524587781 0.01594954023221741 2.9787439254777764e-07 2.0944830972730465e-08 0.015443124704493064 0.005147691974920265 4.1844413453516546e-11 10.378362515406968 -0.2982181171619961 KNQLLLEFSFWNEPVPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KNQLLLEFSFWNEPVPR 17 1 O75323-2;O75323;C9K068;C9J7B1;H7C333 O75323-2 GBAS Protein NipSnap homolog 2 0 19121300.0 2871900.0 5318400.0 10931000.0 False True 4356882.2640135605 4369289.967151141 8770483.058772499 1.0 1.002847839896906 2.0130181463047223 22.054864697170146 -6.907515869362227 0.9124703764864723 0.9662126798778962 2.136866026147326 0.9899501528154855 0.0478058562974164 0.10608437912359449 0.1478420286706823 0.03866471076764322 0.10498339833935022 1.2373259765290486e-07 6.907515869362227 1.1706533462694297 up KNRSK(ub)SEEDWK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 KNRSKSEEDWK 11 3 J3QSB8;Q9BXW6-2;Q9BXW6-4;Q9BXW6 J3QSB8 OSBPL1A Oxysterol-binding protein-related protein 1 2 8506320.0 766420.0 1587500.0 6152400.0 True False 1004784.0420218366 1350651.1880265318 5515808.665988068 1.0 1.3442203812360891 5.489546445113819 19.93845402596852 -6.92334188997823 0.7995422525391255 0.9190758022149728 6.212270588791939 0.9950601000428223 0.14338757629939405 0.09624542213421974 0.09571371798052117 0.12578181447071612 0.38970993031934076 1.193048530172047e-07 6.92334188997823 5.293194786576966 up KNVFIIGATNRPDIIDPAILRPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KNVFIIGATNRPDIIDPAILRPGR 24 3 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 17190400.0 8643400.0 2772100.0 5774900.0 False True 8369019.998157962 3879013.986310523 4262280.446713552 1.0 0.4634967997644051 0.5092926588360033 22.996627264193698 -10.015137096374353 7.5101418228504455 1.0000000206144506 0.48639473055333976 0.9940724826534707 0.01869608117630413 6.464139477627143e-09 8.261065572321618e-10 0.01810240356803008 0.006034134252930647 9.657459679760402e-11 10.015137096374353 -0.5136052900611108 KNVFIIGATNRPDIIDPAILRPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KNVFIIGATNRPDIIDPAILRPGR 24 3 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 65108000.0 15575000.0 23843000.0 25690000.0 False True 23628413.6850208 19588030.363790706 20612360.239672992 1.0 0.8290031918735412 0.8723548061434259 24.49401944013461 -10.825116581739655 7.103963119763061 1.008545855374399 0.8506789990085087 0.9405422615128685 0.017698222414529216 0.0024843842875990232 6.115982710518746e-05 0.017772410694892805 0.005712076722412207 1.495834061433116e-11 10.825116581739655 -0.15786685636589015 KNVFIIGATNRPDIIDPAILRPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KNVFIIGATNRPDIIDPAILRPGR 24 3 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 82527000.0 15575000.0 44338000.0 22614000.0 False True 20162144.529148962 41870551.32376565 18498484.0392346 1.0 2.0766913590581724 0.9174859357094102 24.26514576222706 -6.662782626271508 1.9634407696936673 1.6914690073987235 0.9223317596843379 0.24738298633452294 0.4581291435777136 0.4778418589537572 3.544220513270945 0.1883406250064789 0.507893765875035 2.173788934731582e-07 6.662782626271508 -0.7691372477143856 KPADLQNLAPGTHPPFITFNSEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPADLQNLAPGTHPPFITFNSEVK 24 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 0 11735200.0 4273800.0 1820900.0 5640500.0 False True 4138130.5583598404 2547994.8658680553 4163083.8386271214 1.0 0.6157357362059548 1.0060300853043098 21.980547732387475 -10.947809146630911 10.737633993555065 1.0520384669285607 0.8108829107551324 0.2384152362296511 0.15933700079710958 0.09556635757367264 0.00046450490301224313 0.07427723927559618 0.05142579587682026 1.1276929188580996e-11 10.947809146630911 -0.24115555617342832 KPADLQNLAPGTHPPFITFNSEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPADLQNLAPGTHPPFITFNSEVK 24 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 0 38497400.0 5436000.0 26221000.0 6840400.0 False True 8246809.424832934 21541657.68439194 5488391.941746169 1.0 2.612120224280354 0.6655170089440201 22.975404638103274 -6.686826214374653 1.8776993757346794 2.0137260201483462 0.6725205332927537 0.3554853340381866 0.682266923004932 0.42360220520124403 2.8931201919261054 0.2909477108285625 0.7606913503468993 2.0567134379543796e-07 6.686826214374653 -1.3412054868555925 KPADLQNLAPGTHPPFITFNSEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPADLQNLAPGTHPPFITFNSEVK 24 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 0 9610400.0 4273800.0 2743800.0 2592800.0 False True 3553854.0614422522 2729018.6047983407 3134942.492247301 1.0 0.7679039593682216 0.8821247125086096 21.76095300782175 -10.201617852246445 5.335880284505002 1.0000096145927913 0.8250143359383791 0.7578309208792763 0.04663042720518605 5.333756736993201e-06 7.980269807853608e-07 0.04515219736197211 0.015049905666000122 6.286112479890107e-11 10.201617852246445 -0.1749952786544121 KPADLQNLAPGTHPPFITFNSEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPADLQNLAPGTHPPFITFNSEVK 24 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 0 19993700.0 5436000.0 8584400.0 5973300.0 False True 7037009.159579688 8106670.5937059205 4886220.691233758 1.0 1.1520051217597282 0.6943604279073592 22.746530960195724 -6.817171874996744 1.384031358130161 1.0821724652243117 0.6849603055813972 0.8777575742201141 0.06653830378550535 0.1971857582055264 0.7429402465502117 0.03778594380204676 0.08716448109247556 1.5234497188837044e-07 6.817171874996744 -0.39721215964291445 KPAFNLSAFGTLSPSLGNSSILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPAFNLSAFGTLSPSLGNSSILK 23 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 14158000.0 5816200.0 3698100.0 4643700.0 False True 5631567.914626921 5174770.6153367385 3427375.661986133 1.0 0.9188863019650818 0.6086006089146471 22.42510521591684 -6.9459022323727115 0.6021638725889551 1.0034789758340434 0.5080654348192075 0.9988391116709936 0.005746934487490683 0.08517437260179832 0.04310408581780791 0.0058858036863161526 0.02609410775422784 1.1326553159551093e-07 6.9459022323727115 -0.4954135410148359 KPAFNLSAFGTLSPSLGNSSILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPAFNLSAFGTLSPSLGNSSILK 23 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 13688700.0 5816200.0 2966100.0 4906400.0 False True 4836428.001347852 2950121.0305752475 5932305.555369546 1.0 0.6099793131941768 1.2265882080155617 22.205510491351117 -6.735741777521011 1.7020648402936023 0.7668079390503273 1.2266415065711824 0.5858006087738585 0.16389483021726411 0.32556174666893634 1.8501313949371785 0.07622620976807676 0.18794975938211883 1.8376306355988252e-07 6.735741777521011 0.45983356752085514 KPAFNLSAFGTLSPSLGNSSILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPAFNLSAFGTLSPSLGNSSILK 23 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 69311000.0 30662000.0 20323000.0 18326000.0 False True 39692563.438379765 19192007.18464724 14990856.040639132 1.0 0.4835164454531045 0.37767417223912747 25.24236540217071 -13.999999999999998 0.22281370511658413 4.15568608254301 0.3225630428303399 0.9995008676358546 0.006074044507946495 13.077711457736585 0.14951429033756267 18.185613232522318 0.0575076110885668 1.0000000000000041e-14 13.999999999999998 -3.83312303971267 KPANDITSQLEINFGDLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPANDITSQLEINFGDLGR 19 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 7066500.0 3068800.0 2772300.0 1225400.0 False True 4023226.518301471 2358683.6463407604 1098607.3628668129 1.0 0.5862666781527756 0.2730662461756252 21.939921537123727 -7.940650934617418 0.25590346745895315 1.1640896475942006 6.5884980120310566e-12 0.9996079964238418 0.005894459875823703 0.10761683825688646 0.04448342335633931 0.060522318672989926 0.09252884379172806 1.1464340207286907e-08 7.940650934617418 -1.1640896475876121 down KPANDITSQLEINFGDLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPANDITSQLEINFGDLGR 19 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 27666100.0 20181000.0 7485100.0 0.0 False True 19540365.20152091 10473939.464280834 0.0 1.0 0.5360155430188993 0.0 24.219954095156503 -7.82172658852207 0.6159335604096959 1.0054352439086183 2.7466922241650216e-19 0.988206020003782 0.04437412421287595 0.11603154381818738 0.156733063451193 0.04357880675354329 0.0777707615073348 1.5075558541012547e-08 7.82172658852207 -1.0054352439086183 down KPANDITSQLEINFGDLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPANDITSQLEINFGDLGR 19 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 126300000.0 24215000.0 72829000.0 29256000.0 False True 36735925.35362942 59832095.93442584 23473538.776639685 1.0 1.6287080115300423 0.6389804680480319 25.13068827982487 -6.7350822171003975 1.7048719845751514 1.3761949877927286 0.6390184455166958 0.5826149763327342 0.2642042975119467 0.3267768582765697 1.8629657730102467 0.12270111863884427 0.3027183787217601 1.8404235544631655e-07 6.7350822171003975 -0.7371765422760328 KPANDITSQLEINFGDLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPANDITSQLEINFGDLGR 19 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 32414000.0 20181000.0 5672100.0 6560900.0 False True 16781395.669887733 5641543.2714763 7932753.855825877 1.0 0.33617843130886876 0.47271121019214646 24.00035937059078 -9.893088303962264 6.791544694234638 1.0000000180834685 0.404444820753956 0.9620771460242007 0.05573927357141253 1.5201162465079563e-08 2.605080810104807e-09 0.05396932117633665 0.017989773189309992 1.279121197344083e-10 9.893088303962264 -0.5955551973295126 KPANDITSQLEINFGDLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPANDITSQLEINFGDLGR 19 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 81492000.0 24215000.0 26214000.0 31063000.0 False True 31346794.849010702 24755167.85604204 25409852.733295534 1.0 0.7897192671621196 0.8106044926024538 24.90181460191732 -10.000962195611256 5.006141774204815 1.0000019922939647 0.8001618798800253 0.9918746900721722 0.00852635758981226 1.8959960829178883e-07 3.7843868750399004e-08 0.008255692529256255 0.002751870077973576 9.977869152201468e-11 10.000962195611256 -0.1998401124139394 KPASFMTSICDER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPASFMTSICDER 13 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 30103100.0 7598800.0 8178300.0 14326000.0 False True 9962100.386883888 6958129.518763709 12843682.944695586 1.0 0.6984600885898309 1.2892545192182154 23.24801851827182 -6.767989885113374 1.5824612528279391 0.8265990060976968 1.292303652122145 0.7227018272831824 0.1270180871949511 0.26969085432307566 1.3325786751417255 0.0632835481415198 0.15090144419859652 1.7061221247852244e-07 6.767989885113374 0.46570464602444817 KPASFMTSICDER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPASFMTSICDER 13 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 22945000.0 7598800.0 7741900.0 7604300.0 False True 10408281.709848693 7399837.258960288 5808320.955474512 1.0 0.7109566655904687 0.5580480157429317 23.31122857979471 -13.999999990606018 0.07960782370373723 2.5623130738367217 0.09809821896632397 0.9998882937174414 0.0019368581183226072 12.262419100634212 0.07927357088523102 3.379709573833089 0.41791488914256497 1.0000000216304442e-14 13.999999990606018 -2.4642148548703977 KPCITYGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPCITYGLR 9 1 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;J3QRH4;J3KRJ8 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 8991100.0 2517700.0 2321900.0 4151500.0 False True 3300729.081441486 1975481.5706953139 3721942.6039999803 1.0 0.5984985504573997 1.1276122675219813 21.654353298644786 -6.703813584536852 1.8173994682571257 0.751621252777124 1.1261500911567126 0.43566440102170756 0.1693632227687073 0.3876258733600163 2.4916804324356554 0.07427399290959462 0.19010986628250437 1.9778184117008763e-07 6.703813584536852 0.3745288383795886 KPCITYGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPCITYGLR 9 1 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;J3QRH4;J3KRJ8 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 5540800.0 2517700.0 1290800.0 1732300.0 False True 3448561.72828421 1233768.1878952123 1323166.4178383911 1.0 0.357763115497155 0.3836864531048184 21.717563360167677 -10.477069980847933 6.116102484795869 1.0003986089426178 0.3707247843009946 0.9987288126889081 0.010583158261446337 5.7557267124503504e-05 4.921148821935972e-06 0.01025326469413239 0.003415699641404899 3.333726898074501e-11 10.477069980847933 -0.6296738246416231 KPDEDMK(ub)LYQTPLELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPDEDMKLYQTPLELK 16 2 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 10888900.0 2816500.0 2141300.0 5931100.0 True False 2727091.749174154 2996332.256731984 4377566.980813996 1.0 1.098728070898005 1.6052144128042836 21.37893180784354 -6.9392341644133575 0.6666542537171302 0.9942328291518681 1.738772756843436 0.9980618120731632 0.011671523329105388 0.08811780867919154 0.05621463357617719 0.011296463193110964 0.04374142717061837 1.150180063626913e-07 6.9392341644133575 0.7445399276915678 KPDEDMK(ub)LYQTPLELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPDEDMKLYQTPLELK 16 2 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 9083600.0 2711500.0 3134700.0 3237400.0 True False 3714014.8255322846 2996198.588933316 2472792.796345907 1.0 0.8067276867975096 0.665800464593329 21.82454814353106 -6.974567709691753 0.10083238435558874 1.3434567057282247 0.12549516801514932 0.9999997344005318 7.036477357675931e-05 0.07484664277069243 0.002961473433800883 0.012578432479451309 0.02296224968019281 1.0603086156032242e-07 6.974567709691753 -1.2179615377130755 KPEDVLDDDDAGSAPLK(ub)SSGQHQNDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPEDVLDDDDAGSAPLKSSGQHQNDK 26 2 P35613-2;P35613;A0A087WUV8;P35613-3;P35613-4 P35613-2 BSG Basigin 1 10002200.0 3165300.0 3262300.0 3574600.0 True False 4149738.9528088076 2775577.5563458 3204734.681984425 1.0 0.6688559420025957 0.7722738028654204 21.984589153173218 -10.55725142693981 9.20822520978591 1.0000234073596461 0.7205648724340081 0.9068416416467419 0.042220164900677815 2.02902053291947e-05 9.755896077587242e-07 0.04088291305629489 0.013626499627871333 2.7717150057752586e-11 10.55725142693981 -0.279458534925638 KPEDVLDDDDAGSAPLK(ub)SSGQHQNDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPEDVLDDDDAGSAPLKSSGQHQNDK 26 2 P35613-2;P35613;A0A087WUV8;P35613-3;P35613-4 P35613-2 BSG Basigin 1 10617400.0 3165300.0 2592100.0 4860000.0 True False 4335596.949016169 2477572.4510715697 3712168.094841876 1.0 0.5714489792769549 0.8562069164856847 22.04779921469611 -10.18884374726679 5.316284949870751 1.0000139408559412 0.713827947881243 0.5738531541249597 0.1162519410617498 1.9209747168860337e-05 2.931111615312961e-06 0.11256593864694409 0.03752015264133132 6.473754899830692e-11 10.18884374726679 -0.28618599297469816 KPEDWDEEMDGEWEPPVIQNPEYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPEDWDEEMDGEWEPPVIQNPEYK 24 1 P27797;K7EJB9;K7EL50 P27797 CALR Calreticulin 0 46382600.0 15316000.0 4096600.0 26970000.0 False True 14829801.963554539 5732393.743486786 19905747.917343073 1.0 0.38654553564333605 1.3422800902037053 23.821995996454152 -6.733377944398381 1.71115872226417 0.632222205916351 1.342047282331272 0.5747875308671202 0.2578190409474122 0.32992125380091886 1.8940691737003539 0.11933289175030175 0.2949631064336554 1.8476599946105578e-07 6.733377944398381 0.7098250764149209 KPEGKPDQK(ub)FDQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPEGKPDQKFDQK 13 3 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6RBK5 P43243 MATR3 Matrin-3 1 16296600.0 3761100.0 7539100.0 4996400.0 True False 4930838.522544207 6414295.667181636 4479420.456853065 1.0 1.3008529153520114 0.9084500407735477 22.233401576870317 -6.701820993383987 1.8240737407336332 1.1864771662793143 0.9095636877005714 0.4263967876533741 0.12695111665006012 0.3917279930955796 2.5351230507284073 0.055493471040919645 0.1424106303023309 1.9869137106525387e-07 6.701820993383987 -0.27691347857874293 KPEGKPDQK(ub)FDQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPEGKPDQKFDQK 13 3 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6RBK5 P43243 MATR3 Matrin-3 1 16072700.0 4572800.0 6795300.0 4704600.0 True False 4427638.967024171 9508698.727021355 3472324.1250252943 1.0 2.1475777040177646 0.7842383154738232 22.078106157812446 -6.683509245968394 1.8893127889955281 1.7237886738391417 0.7892738382226464 0.3402640116797795 0.48600290497217286 0.4308008298400979 2.9759871486924143 0.206178517427233 0.5413706548041697 2.072481936741366e-07 6.683509245968394 -0.9345148356164953 KPEGKPDQK(ub)FDQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPEGKPDQKFDQK 13 3 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6RBK5 P43243 MATR3 Matrin-3 1 15278000.0 2577900.0 2652400.0 10047700.0 True False 3910862.769734516 2179058.49670421 8061767.690936637 1.0 0.5571810173365231 2.061378311027748 21.89905548281846 -6.827879019863565 1.3374384751509616 0.7630209940661024 2.1001071911547857 0.9015503518541904 0.19803586962828884 0.18344387598973877 0.6424994275011066 0.11628656069099134 0.2676312347639623 1.486349632667665e-07 6.827879019863565 1.3370861970886834 up KPEGKPDQK(ub)FDQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPEGKPDQKFDQK 13 3 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6RBK5 P43243 MATR3 Matrin-3 1 17448800.0 3761100.0 7185500.0 6502200.0 True False 5151680.309905754 6868020.850729047 4966514.277012521 1.0 1.3331613061321137 0.9640571577127579 22.29661163839321 -6.668884163991 1.9408667659823247 1.212848787720079 0.9655392423738883 0.27436976507316446 0.14155412649947582 0.46364642834055514 3.365949696270386 0.058731694145671684 0.15717146170167626 2.1434622339905326e-07 6.668884163991 -0.24730954534619076 KPEGKPDQK(ub)FDQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPEGKPDQKFDQK 13 3 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6RBK5 P43243 MATR3 Matrin-3 1 13525600.0 4572800.0 5615100.0 3337700.0 True False 3802485.8093881677 5584850.341789911 4035597.6382188397 1.0 1.4687366690498 1.061305114737083 21.858511433246722 -10.316793311756422 5.629532010934632 0.9999622316127372 1.265020891893425 0.3606724959796671 0.16633323552921103 7.886075511991839e-05 9.570966111191508e-06 0.16107437685748033 0.05368382092711775 4.8217721949314546e-11 10.316793311756422 0.2650586602806877 KPEGKPDQK(ub)FDQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPEGKPDQKFDQK 13 3 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6RBK5 P43243 MATR3 Matrin-3 1 9670100.0 2577900.0 1860200.0 5232000.0 True False 3337142.3680059756 1756678.2347527824 4279829.684853425 1.0 0.5264019454472483 1.282483398336622 21.67018180491091 -6.737368742263048 1.6964871696313066 0.7173546455195343 1.2826641533135932 0.5930194313141564 0.19900131247182168 0.3225903415014339 1.8219769944293416 0.09284011828492987 0.22846882246575087 1.8307593369592766e-07 6.737368742263048 0.5653095077940589 KPENDDDVEIK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPENDDDVEIKK 12 2 Q13433;Q13433-2;K7EQ91 Q13433 SLC39A6 Zinc transporter ZIP6 1 3993300.0 1014800.0 1206400.0 1772100.0 True False 1330412.6273371808 1026409.8225103697 1588740.0911835146 1.0 0.7714973545949633 1.1941709350454497 20.343442336169538 -6.759888294413093 1.6129949642077939 0.8672539543009454 1.1957010654243445 0.6904749147702945 0.09610686769304598 0.2831035071770924 1.4516929254872817 0.047012923720765605 0.11298721784827327 1.7382478688038964e-07 6.759888294413093 0.3284471111233991 KPENDDDVEIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPENDDDVEIKK 12 2 Q13433;Q13433-2;K7EQ91 Q13433 SLC39A6 Zinc transporter ZIP6 1 4840720.0 978830.0 954790.0 2907100.0 True False 947757.5774344531 1336042.626164072 2145643.2988694124 1.0 1.4096881501920493 2.2639157417001026 19.854158560397128 -6.959221919530506 0.44626357498932323 0.9713762954941051 2.735881499264536 0.9997402460464749 0.008485897896385012 0.07998023708739559 0.022167125738498595 0.01135615061956399 0.07069992290318654 1.0984444034300891e-07 6.959221919530506 1.764505203770431 up KPENDDDVEIK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPENDDDVEIKK 12 2 Q13433;Q13433-2;K7EQ91 Q13433 SLC39A6 Zinc transporter ZIP6 1 5644930.0 772630.0 2034900.0 2837400.0 True False 1172136.1968191084 1671756.1962537316 2276586.6463234015 1.0 1.4262473941086966 1.9422543664307117 20.160708783332993 -6.968574583884917 0.29022211913386364 0.8994431963623833 2.4850059393340596 0.9999690297722267 0.002143971486668105 0.0767680186558804 0.010677353853625431 0.009004155903577274 0.046781804542004306 1.0750419614101438e-07 6.968574583884917 1.585562742971676 KPENDDDVEIK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPENDDDVEIKK 12 2 Q13433;Q13433-2;K7EQ91 Q13433 SLC39A6 Zinc transporter ZIP6 1 3810510.0 1014800.0 709110.0 2086600.0 True False 1389998.9839388398 677779.1754868106 1593788.0548759406 1.0 0.4876112740501349 1.1466109495703543 20.40665239769243 -6.699187265190065 1.8338613137277575 0.6815757234265509 1.144616433632509 0.41371431397242797 0.21631748711412144 0.3971960663839154 2.5964204568279814 0.09412653903767623 0.2423033715930721 1.9989997270123104e-07 6.699187265190065 0.46304071020595816 KPESEGYLQEEK(ub)QK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPESEGYLQEEKQK 14 2 Q53EZ4;Q53EZ4-2;H0Y432 Q53EZ4 CEP55 Centrosomal protein of 55 kDa 1 3564410.0 1225100.0 1433000.0 906310.0 True False 1606117.963885276 1219201.985790251 812533.735139401 1.0 0.7590986547718719 0.5058991639529659 20.61514642709992 -6.970496400243978 0.24603950689064388 1.0843718421783384 0.17324715041677016 0.9999859992932049 0.0007548263935046695 0.07614194545721888 0.008451728869382695 0.005802293672454199 0.024427026836246025 1.0702952542785789e-07 6.970496400243978 -0.9111246917615682 KPESEGYLQEEK(ub)QK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPESEGYLQEEKQK 14 2 Q53EZ4;Q53EZ4-2;H0Y432 Q53EZ4 CEP55 Centrosomal protein of 55 kDa 1 3316790.0 746690.0 1346800.0 1223300.0 True False 722986.7346674422 1884584.263469215 902881.0317866432 1.0 2.606665064658596 1.2488210204879464 19.463609651343404 -6.605019496827717 2.1722245090039034 2.0769993579003145 1.2534757978215034 0.03514164276265097 0.6935691545787682 0.6265550638983677 5.594864204923285 0.264348799052185 0.7706346242210967 2.4830216322428917e-07 6.605019496827717 -0.8235235600788111 KPESEGYLQEEK(ub)QK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPESEGYLQEEKQK 14 2 Q53EZ4;Q53EZ4-2;H0Y432 Q53EZ4 CEP55 Centrosomal protein of 55 kDa 1 12671800.0 2509900.0 4869100.0 5292800.0 True False 3807701.7982686176 4000171.0625480628 4246675.7600833485 1.0 1.050547357560133 1.1152858036347109 21.860489067138936 -6.967749937469966 0.3072140354394859 0.9896926311596234 1.1781901161849393 0.999959116618242 0.000301639407866856 0.07703973646034237 0.011629901205885276 0.0010374499067581301 0.005763270689371741 1.0770852102854701e-07 6.967749937469966 0.18849748502531594 KPESEGYLQEEK(ub)QK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPESEGYLQEEKQK 14 2 Q53EZ4;Q53EZ4-2;H0Y432 Q53EZ4 CEP55 Centrosomal protein of 55 kDa 1 3165290.0 1225100.0 969990.0 970200.0 True False 1678052.577082647 927132.6344720162 741058.7418962125 1.0 0.5525051164272032 0.4416183092335336 20.67835648862281 -13.999999999999998 0.19593722214981796 3.4501051920965313 0.3666503921447766 0.9994872240749924 0.005465725859895297 12.453474438047726 0.14036919816368204 11.674388434728597 0.07280715613507957 1.0000000000000041e-14 13.999999999999998 -3.0834547999517548 KPESEGYLQEEK(ub)QK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPESEGYLQEEKQK 14 2 Q53EZ4;Q53EZ4-2;H0Y432 Q53EZ4 CEP55 Centrosomal protein of 55 kDa 1 3344740.0 746690.0 1823700.0 774350.0 True False 620905.8189756937 1813875.3661238942 936263.0048101267 1.0 2.9213373601752335 1.5078985833224703 19.24401492677768 -6.5673549968013045 2.3168464031335456 2.3181728089816898 1.5106267716090023 0.0 0.837348841348705 0.7382061875689079 7.434976641028577 0.3059373613697122 0.9395597091569359 2.7079771983938376e-07 6.5673549968013045 -0.8075460373726875 KPESEGYLQEEK(ub)QK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPESEGYLQEEKQK 14 2 Q53EZ4;Q53EZ4-2;H0Y432 Q53EZ4 CEP55 Centrosomal protein of 55 kDa 1 14990100.0 2509900.0 5225700.0 7254500.0 True False 3249115.0275255847 4934885.201240518 5934255.437455888 1.0 1.5188397946621048 1.8264220833003917 21.631615389231385 -9.4793904722067 0.11960839651860188 5.320896862017984e-17 2.521860263491267 0.999900740489945 0.003397745646146623 0.9471653437773079 0.047420681634060394 0.6450915431970148 0.3359458418911991 3.3159618685221103e-10 9.4793904722067 2.521860263491267 KPFTPVK(ub)YFSIDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPFTPVKYFSIDR 13 2 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 1 126746700.0 8245700.0 21340000.0 97161000.0 True False 12509329.741417393 17531710.269818977 77957085.7628209 1.0 1.4014907778610137 6.231915488222459 23.576501155183017 -6.9233555058447065 0.7994391710418393 0.9057521765206371 7.074354053354068 0.9950635467573584 0.16703401020245087 0.09623738245014117 0.09567457797084737 0.14653642414280302 0.4540790042125978 1.1930111266693058e-07 6.9233555058447065 6.168601876833431 up KPFTPVK(ub)YFSIDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPFTPVKYFSIDR 13 2 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 1 113707700.0 8245700.0 26096000.0 79366000.0 True False 10674221.197046772 24643734.659772355 64922202.36392911 1.0 2.3087150064484816 6.082148867393818 23.347627477275466 -6.952339082370125 0.5325463429282508 0.9415542247017952 7.621356582601065 0.9993722887933043 0.053981100390961684 0.0825598776326333 0.032178833151779954 0.060000287846299044 0.3121486320939425 1.1159915792469034e-07 6.952339082370125 6.67980235789927 KPGEK(ub)TFTQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPGEKTFTQR 10 2 Q15233;C9JYS8;C9IZL7;C9J4X2 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 27485900.0 6447300.0 11372000.0 9666600.0 True False 8452472.735742012 9675341.927708821 8666392.960574783 1.0 1.1446759108486444 1.025308596847428 23.010942026899706 -10.42414952090387 4.507164348393887 0.9997842620256101 1.0849922538481576 0.4033301417869133 0.04873150187867217 0.00010591083016563969 1.353148637993802e-05 0.04730361829490337 0.01572802460092312 3.765741279886667e-11 10.42414952090387 0.08520799182254746 KPGEK(ub)TFTQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPGEKTFTQR 10 2 Q15233;C9JYS8;C9IZL7;C9J4X2 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 25586700.0 3310700.0 3887000.0 18389000.0 True False 5022573.944590579 3193334.4807303804 14754406.089814961 1.0 0.6357964095620078 2.937618490556177 22.259995468443783 -6.866417410690234 1.1527939253597876 0.7978482974384951 3.0636027023950767 0.9609795582051811 0.19956011447718408 0.1403408928246728 0.3508117128918459 0.1346124885993191 0.31688284312315496 1.3601367944283567e-07 6.866417410690234 2.2657544049565814 up KPGEK(ub)TFTQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPGEKTFTQR 10 2 Q15233;C9JYS8;C9IZL7;C9J4X2 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 28690300.0 6447300.0 10012000.0 12231000.0 True False 8831041.041731246 9569636.734743472 9342289.705352057 1.0 1.083636310772646 1.0578922305088263 23.074152088422597 -10.077043886681555 4.568701654833181 0.9999957036235595 1.0707642706434821 0.9097002777348201 0.010509976766630992 7299224.0181383565 0.022509914434564113 329.9135950509677 0.0035978445948132553 8.374446517082991e-11 10.077043886681555 0.07076856701992262 KPGEK(ub)TFTQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPGEKTFTQR 10 2 Q15233;C9JYS8;C9IZL7;C9J4X2 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 32899280.0 8944100.0 23470000.0 485180.0 True False 7437415.440812789 23343562.45156978 586628.8947811418 1.0 3.1386659300315634 0.07887537000582459 22.826369930102565 -6.7188149165490305 1.763622869075736 2.302822610481805 0.08400959287961908 0.5068142112606886 0.900098418636698 0.3576724472008042 2.1735378336644158 0.4053431100521157 1.0189672564139913 1.9106673549437093e-07 6.7188149165490305 -2.218813017602186 KPGEK(ub)TFTQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPGEKTFTQR 10 2 Q15233;C9JYS8;C9IZL7;C9J4X2 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 16793400.0 3310700.0 2992700.0 10490000.0 True False 4285766.413653508 2826153.614205271 8580927.636489386 1.0 0.6594278225714234 2.0021920954796886 22.031121790536233 -6.839461678311892 1.2848632182077824 0.8188096081002586 2.0458974999219772 0.923534221214007 0.15759992291747407 0.16942387194285238 0.5435432732580703 0.09618882988005988 0.2215731142398389 1.4472325497383122e-07 6.839461678311892 1.2270878918217187 up KPGGFDISLFYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPGGFDISLFYR 12 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 38901100.0 6605100.0 13131500.0 19164500.0 False True 8659350.06387938 11172331.386186099 17181541.378864907 1.0 1.2902043806716026 1.9841606185357974 23.045827315430248 -6.956407663954031 0.48341310764765333 0.9838665090065714 2.3195986759936535 0.9996128801489543 0.008123923683997853 0.08101028065544279 0.02606966313716272 0.009853329732124664 0.05723978301368823 1.1055855047027421e-07 6.956407663954031 1.335732166987082 KPGGFDISLFYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPGGFDISLFYR 12 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 41488800.0 8666900.0 12507200.0 20314700.0 False True 8391774.003521206 17501390.18418638 14993670.642063357 1.0 2.085541171252081 1.786710490031307 23.000544394952716 -10.07318512641148 4.404988911407409 0.9999253931501575 1.9361258307208749 0.928999917429693 0.12199711503896399 14008767.8642477 6406963.97470492 9939.003814518977 0.041762857748189386 8.449186055106578e-11 10.07318512641148 0.9362004375707174 KPGGFDISLFYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPGGFDISLFYR 12 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 292469000.0 30576000.0 108448000.0 153445000.0 False True 46386027.405020624 89094607.09190868 123116528.49266736 1.0 1.9207207876194516 2.654172719247386 25.46718696031334 -6.973694210578118 0.14491224970818137 0.08405983036094125 4.510041795648826 0.9999987494806318 0.0007567693161509009 0.07512114015814876 0.004408189964185684 0.039405265875434435 0.0934689000598682 1.0624433668230755e-07 6.973694210578118 4.4259819652878845 KPGGFDISLFYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPGGFDISLFYR 12 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 48103500.0 6605100.0 16909400.0 24589000.0 False True 9047183.966115896 16162286.796091806 18781584.62635123 1.0 1.786443920740847 2.075959182071819 23.10903737695314 -10.49798630883447 0.2147286855941504 1.6591368488033976e-17 2.2856959875991567 0.9993081983504963 0.011957106950678644 2.2007307640576776 0.10857953903496514 1.339850682205803 0.16140607978922944 3.176974223417494e-11 10.49798630883447 2.2856959875991567 KPGGFDISLFYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPGGFDISLFYR 12 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 18860240.0 8666900.0 4476740.0 5716600.0 False True 7206911.35877062 4452622.913056685 6911914.6294280095 1.0 0.617826790340353 0.9590675235676921 22.780949670386992 -10.286243273442127 7.989411062322388 1.0000004196845476 0.7884471569540226 0.33882278820789147 0.1393109459766963 1.0415092450264531e-06 9.308499321907159e-08 0.13488751074726024 0.04496241447601217 5.173169716369496e-11 10.286243273442127 -0.211553262730525 KPGGFDISLFYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPGGFDISLFYR 12 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 208433000.0 30576000.0 120603000.0 57254000.0 False True 39581234.74306638 113891337.03144264 46834359.47564955 1.0 2.877407381824881 1.183246550535004 25.23831328240579 -6.62158011041493 2.111063931849671 2.2442988012078655 1.1897710997990785 0.08819024199105296 0.8070174786264355 0.5810832812898543 4.923147321595729 0.3138844950437794 0.8946325231303965 2.390121010454596e-07 6.62158011041493 -1.054527701408787 KPGINVASDWSIHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPGINVASDWSIHLR 15 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 9706800.0 3026100.0 1338800.0 5341900.0 False True 2930038.1119033955 1873389.82174977 3942696.13643511 1.0 0.6393738750834161 1.3456125776718573 21.482487999670138 -6.767895962486628 1.5824446616844468 0.792597103595568 1.3492777935944256 0.7224538318357763 0.15190645011566808 0.2698546412035163 1.3332837699977835 0.07567891003709602 0.1805018019791114 1.7064911389149214e-07 6.767895962486628 0.5566806899988576 KPGINVASDWSIHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPGINVASDWSIHLR 15 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 29496400.0 8213800.0 7656600.0 13626000.0 False True 12460935.109215006 6290219.908711161 10932815.127512043 1.0 0.5047951741646958 0.8773671503535155 23.57090900117749 -9.759093573823659 6.062284969197635 1.0000000092707728 0.6910811622583399 0.47825840498561734 0.15210187235656178 1.888905117189189e-08 3.981958018728357e-09 0.1472720090288259 0.0490906682132602 1.7414316211641834e-10 9.759093573823659 -0.3089188470124329 KPGINVASDWSIHLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPGINVASDWSIHLR 15 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 5436500.0 3026100.0 1140600.0 1269800.0 False True 2516336.2289602733 1134455.3614086253 1535309.3091081553 1.0 0.450836159473558 0.6101367899243461 21.262893275104414 -10.761777775415153 10.545904150921672 1.0014433756035914 0.5304864746989983 0.9205241422143092 0.06503421005134982 0.0022110931881670873 4.9946448327927855e-05 0.0630851782009265 0.02098970103855275 1.7307017172016208e-11 10.761777775415153 -0.4709569009045931 KPGINVASDWSIHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPGINVASDWSIHLR 15 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 29691000.0 8213800.0 14850000.0 6627200.0 False True 10632926.018203763 14023584.44580089 5421117.600814347 1.0 1.318882913488936 0.509842501634385 23.34203532326994 -6.7997716575312905 1.4569512552511135 1.1759805554894076 0.4987458202539658 0.8315223142568935 0.13657958030475267 0.22104779145951164 0.9263960004260535 0.07375150950194376 0.17153458693535614 1.5857267134821627e-07 6.7997716575312905 -0.6772347352354418 KPIIGILMQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPIIGILMQK 10 1 Q92820 Q92820 GGH Gamma-glutamyl hydrolase 0 22444800.0 5490600.0 7541300.0 9412900.0 False True 7198229.771046034 6416167.4357571695 8438943.402912546 1.0 0.8913535188283915 1.1723637159871063 22.779210723859382 -6.801922238655213 1.448479939683358 0.9402001497268986 1.1764100693615533 0.8375982560690626 0.04662637337958852 0.21803351818813063 0.9029847793887039 0.025323585754190588 0.0588143978757765 1.577893769621531e-07 6.801922238655213 0.23620991963465476 KPIIGILMQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPIIGILMQK 10 1 Q92820 Q92820 GGH Gamma-glutamyl hydrolase 0 15017300.0 7660900.0 2237800.0 5118600.0 False True 7417708.922864644 3131365.2099728384 3777885.1052915184 1.0 0.42214722126943977 0.5093061947532632 22.822542225709327 -10.748675449260354 6.996746033936732 1.0093177147507797 0.4657267080113515 0.9804306925033929 0.03558250192335609 0.005145997158893902 0.00018484506185348568 0.03428055064680106 0.011484203113795954 1.7837112470744978e-11 10.748675449260354 -0.5435910067394282 KPIIGILMQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPIIGILMQK 10 1 Q92820 Q92820 GGH Gamma-glutamyl hydrolase 0 22179100.0 5490600.0 4892500.0 11796000.0 False True 7520623.197885871 4676333.172666042 9010027.746245855 1.0 0.6218012855610969 1.1980427032667549 22.842420785382274 -6.729655291066059 1.724539352912378 0.7723150711309166 1.1976754261675167 0.5576595034899636 0.1589898157782005 0.33687693318139494 1.9626375009965902 0.07306469780833007 0.1813722562691186 1.8635657022496126e-07 6.729655291066059 0.4253603550366001 KPIIGILMQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPIIGILMQK 10 1 Q92820 Q92820 GGH Gamma-glutamyl hydrolase 0 13179300.0 7660900.0 2391900.0 3126500.0 False True 6370377.785414142 2379014.359945022 3780236.694697308 1.0 0.3734494939047577 0.5934085578649168 22.602947501143603 -10.135740155651376 5.212924083808732 1.0000161364888582 0.483429025884393 0.880294772982396 0.08979791183531745 1.6841128155234448e-05 2.7922359949749024e-06 0.08694916654318073 0.028982151421642236 7.315766649233913e-11 10.135740155651376 -0.5165871106044653 KPLFHGDSEIDQLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPLFHGDSEIDQLFR 15 1 P06493;A0A024QZP7;P06493-2;A0A087WZZ9 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 0 5138400.0 1930200.0 1876700.0 1331500.0 False True 2530510.892083391 1596703.6753193059 1193729.15264988 1.0 0.630980755828609 0.4717344455558034 21.270997253479493 -13.999999999999998 0.1145535645158215 2.768396456093179 0.19786094185604397 0.9997200292799625 0.0037021696854070392 11.987855074360104 0.10342015422306056 4.864663147433295 0.24305918103238017 1.0000000000000041e-14 13.999999999999998 -2.570535514237135 KPLFHGDSEIDQLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPLFHGDSEIDQLFR 15 1 P06493;A0A024QZP7;P06493-2;A0A087WZZ9 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 0 5398100.0 1930200.0 1218100.0 2249800.0 False True 2643847.1016936805 1164280.314281963 1718443.576085445 1.0 0.44037354260619344 0.649978425372855 21.334207315002384 -10.146568868653404 5.283219859518966 1.0000140922093639 0.5451759839892846 0.8626000000098637 0.08557083506321521 1.4204239061721355e-05 2.2944719829222643e-06 0.08285616909342243 0.027617868259952303 7.135610425409925e-11 10.146568868653404 -0.4548381082200793 KPLIIFTPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPLIIFTPK 9 1 E9PDF2;E9PCR7;Q02218-2;Q02218;E9PFG7;A0A0D9SFS3;Q9ULD0-3;Q9ULD0-2;Q9ULD0 E9PDF2 OGDH;OGDHL 2-oxoglutarate dehydrogenase, mitochondrial;2-oxoglutarate dehydrogenase-like, mitochondrial 0 7360400.0 2018600.0 1914200.0 3427600.0 False True 2646404.1481502056 1628608.8214931597 3072944.8318608515 1.0 0.6154044243890455 1.1611774543237439 21.335601970324113 -6.717350165326792 1.7688551456119979 0.7653574306749561 1.1602025719775353 0.49998547713007413 0.16189396925969896 0.3604894994774091 2.2028521806295025 0.07271320281691149 0.18310836643592573 1.917122369451238e-07 6.717350165326792 0.3948451413025792 KPLILVYMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPLILVYMR 9 1 A0A087X0W9;Q8N6M0;Q8N6M0-2 A0A087X0W9 OTUD6B OTU domain-containing protein 6B 0 8891300.0 2999200.0 3621500.0 2270600.0 False True 3931980.244294114 3081186.3164964383 2035660.0931331695 1.0 0.7836220237799252 0.5177187998559286 21.906824642393687 -6.968358146331827 0.29477559871233794 1.049075552432216 0.24399477211885476 0.9999665934373603 0.0011399793350711108 0.07683912456409595 0.010926948883520724 0.004529841311366398 0.023983156951098518 1.0755778591723249e-07 6.968358146331827 -0.8050807803133612 KPLILVYMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPLILVYMR 9 1 A0A087X0W9;Q8N6M0;Q8N6M0-2 A0A087X0W9 OTUD6B OTU domain-containing protein 6B 0 42753600.0 8837600.0 11015000.0 22901000.0 False True 13407285.315103663 9049287.189412182 18374607.312135115 1.0 0.6749529809153774 1.3704942410254843 23.676513816524007 -6.779615299826723 1.537268032886699 0.8158597118427303 1.3759478421328104 0.766064999040572 0.1374370061328308 0.2511698463973131 1.1723612132902639 0.07041655032280035 0.1662140421116472 1.6610576289159895e-07 6.779615299826723 0.5600881302900801 KPLILVYMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPLILVYMR 9 1 A0A087X0W9;Q8N6M0;Q8N6M0-2 A0A087X0W9 OTUD6B OTU domain-containing protein 6B 0 11829600.0 2999200.0 4013100.0 4817300.0 False True 4108085.290332441 3835787.9724529632 3679552.955407778 1.0 0.9337167320940791 0.8956856285498432 21.97003470391658 -13.999999966412021 0.06289348038349961 1.4092154108087014 0.7349006491220936 0.9999464314250754 0.0003154252054514307 12.434075956181488 0.0652290261494837 0.7836933116554965 0.1499059704964058 1.000000077339182e-14 13.999999966412021 -0.6743147616866078 KPLILVYMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPLILVYMR 9 1 A0A087X0W9;Q8N6M0;Q8N6M0-2 A0A087X0W9 OTUD6B OTU domain-containing protein 6B 0 3718820.0 1518300.0 786620.0 1413900.0 False True 1262533.722094572 782382.3219281557 1709539.9528650336 1.0 0.6196922175117555 1.354054884196573 20.267890491880785 -6.765946248707412 1.5898583478735915 0.7807382015992982 1.357577815060756 0.7148495161688087 0.1601269777389251 0.27303960620415224 1.3613546593502295 0.07941680461659949 0.189765313777477 1.7141694518619874e-07 6.765946248707412 0.5768396134614578 KPLILVYMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPLILVYMR 9 1 A0A087X0W9;Q8N6M0;Q8N6M0-2 A0A087X0W9 OTUD6B OTU domain-containing protein 6B 0 34689600.0 8837600.0 11931000.0 13921000.0 False True 11440447.415140072 11267029.361808106 11387520.841522293 1.0 0.9848416720920838 0.995373732189203 23.447640138616457 -10.180725066967693 4.437594200772343 1.0000022892197762 0.9901077021403928 0.5404974167011632 0.004299695530561037 9.740349782942303e-08 1.7979140886258878e-08 0.004164125727481647 0.001387720765183156 6.595913218097346e-11 10.180725066967693 -0.009894587079383399 KPLLESGTLGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPLLESGTLGTK 12 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 15761460.0 5334760.0 1275900.0 9150800.0 False True 5165410.963899981 1785373.5237306007 6753930.961884423 1.0 0.3456401700093598 1.307530225394705 22.300451704860638 -6.72356144774347 1.7468494059114887 0.603409419768779 1.3063034791691501 0.5291207268456589 0.2752434097848803 0.3484393488800162 2.079862388936516 0.1250279617995847 0.3125185251279428 1.8898988130220052e-07 6.72356144774347 0.7028940594003711 KPLLESGTLGTK(ub)GNVQVVIPFLTESYSSSQDPPEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEK 35 2 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 741280000.0 27833000.0 666612000.0 46835000.0 True False 42224695.86485927 547649880.3366716 37578041.7214903 1.0 12.969895202784473 0.8899541122038949 25.331583695862484 -6.648281729701194 2.0149120019973483 8.777908424744089 0.9407861453740204 0.18708714145975303 5.111066218045023 0.5126817649668756 3.9877127676295565 2.058736316876898 5.659880388923911 2.247596102367793e-07 6.648281729701194 -7.837122279370068 KPLLESGTLGTK(ub)GNVQVVIPFLTESYSSSQDPPEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEK 35 2 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 154013000.0 46988000.0 52995000.0 54030000.0 True False 39072603.92134608 52709505.41631607 65327423.19350576 1.0 1.349014402071112 1.671949566632701 25.219654068676867 -6.97205735736692 0.203121889317268 0.8153566278435261 2.2145539255443016 0.99999429493086 0.0006553656287932785 0.07564060737892274 0.006583925357754529 0.01022016826665131 0.03401756199848451 1.0664552649496284e-07 6.97205735736692 1.3991972977007756 KPLLESGTLGTK(ub)GNVQVVIPFLTESYSSSQDPPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPLLESGTLGTKGNVQVVIPFLTESYSSSQDPPEK 35 2 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 468075000.0 27833000.0 409618000.0 30624000.0 True False 36030367.170452796 386822398.21683943 25050746.228775114 1.0 10.736010443270157 0.6952675811008201 25.102710017954934 -6.653175787423487 1.9970519409716014 7.301661042020881 0.7373127616442965 0.2071212832613708 4.152185405067256 0.5007724427682916 3.83166088747395 1.684064289753027 4.600393423686395 2.222410153613492e-07 6.653175787423487 -6.564348280376585 KPLPDHVSIVEPK(ub)DEILPTTPISEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPLPDHVSIVEPKDEILPTTPISEQK 26 2 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 3466785700.0 809046800.0 1719793000.0 937945900.0 True False 1060668189.6203569 1463206588.100608 840896255.6803819 1.0 1.3795139728139967 0.792798599891416 29.982326260420074 -6.732059993625916 1.7155400074821092 1.227859085869636 0.7930015001921342 0.5688936202051003 0.15951417030903264 0.3323772316564526 1.9172918100113097 0.07365396334495085 0.1823551011589792 1.8532755934461783e-07 6.732059993625916 -0.4348575856775019 KPLPDHVSIVEPK(ub)DEILPTTPISEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPLPDHVSIVEPKDEILPTTPISEQK 26 2 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 3321211200.0 1228000000.0 814381400.0 1278829800.0 True False 1189017812.173215 1139568139.962897 943865911.3083522 1.0 0.9584113276487114 0.7938198247705063 30.147123181636257 -6.94511972269733 0.6100785322473349 1.001820362823558 0.7418382571350439 0.998760466362276 0.0031343249958514655 0.08550669862536135 0.04454353581042995 0.0031857320831302307 0.013879155893850527 1.1346979684368695e-07 6.94511972269733 -0.2599821056885141 KPLPDHVSIVEPK(ub)DEILPTTPISEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPLPDHVSIVEPKDEILPTTPISEQK 26 2 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 4647613000.0 1490725000.0 2394998000.0 761890000.0 True False 2261538811.595672 1967591894.6952171 611302107.5517508 1.0 0.8700234922375464 0.27030361115953383 31.074657609104882 -6.941612702705227 0.6443939346840016 1.006589117471001 0.1006099858950321 0.9983674929817096 0.01284078784980398 0.08703877433676716 0.051318310446226145 0.012657833522948966 0.05126116471537585 1.143897991109368e-07 6.941612702705227 -0.905979131575969 down KPLPDHVSIVEPK(ub)DEILPTTPISEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPLPDHVSIVEPKDEILPTTPISEQK 26 2 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 2919275800.0 809046800.0 1308641500.0 801587500.0 True False 1108173265.6276793 1250821391.4312618 612269041.712771 1.0 1.1287236664410825 0.5525029891115234 30.045536321942965 -6.84807345127783 1.2444036716098381 1.0685931519727876 0.5303163936754667 0.9374476354845966 0.06176307041186941 0.15958929739525674 0.4765418947336163 0.03885677318715898 0.08981046440869533 1.4188175398820671e-07 6.84807345127783 -0.5382767582973209 KPLPDHVSIVEPK(ub)DEILPTTPISEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPLPDHVSIVEPKDEILPTTPISEQK 26 2 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 3072141800.0 1228000000.0 1332325200.0 511816600.0 True False 1021136409.6240084 1325147699.701753 618835084.6874197 1.0 1.2977185880480788 0.6060258735806711 29.927528457070533 -6.789727212504797 1.4973296704803776 1.166453886358253 0.5987149017348177 0.8004678417475741 0.12654390464245355 0.2357580420445049 1.0441971061499171 0.06652135883465138 0.15578003108073207 1.6228291029047742e-07 6.789727212504797 -0.5677389846234353 KPLPDHVSIVEPK(ub)DEILPTTPISEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPLPDHVSIVEPKDEILPTTPISEQK 26 2 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 4530286000.0 1490725000.0 2448551000.0 591010000.0 True False 1929772899.0828602 2312286984.4006877 483452244.2746989 1.0 1.1982171505774697 0.25052286955862185 30.84578393119733 -6.852106340637875 1.2248778087958498 1.1059970592879393 0.21106865771285202 0.9433167640140433 0.09716856215874972 0.15515377281062745 0.4468900621260867 0.06203977481470601 0.14377088314170008 1.4057032837752417e-07 6.852106340637875 -0.8949284015750874 down KPLTLSLHGWAGTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPLTLSLHGWAGTGK 15 1 O14657;H0Y7C8 O14657 TOR1B Torsin-1B 0 6361000.0 934300.0 2388800.0 3037900.0 False True 1279735.9585081374 2283254.9172947654 2320410.5875144335 1.0 1.7841609451659766 1.8131948016991497 20.287414746232244 -11.16389264192546 0.5569330568159878 3.246012861506977e-11 1.8105253045656529 0.9998936570342228 0.003884493628118035 3.2852144538833215 0.2735535603280966 4.116123516020866 0.005364910752306888 6.856577008439482e-12 11.16389264192546 1.8105253045331928 KPLTLSLHGWAGTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPLTLSLHGWAGTGK 15 1 O14657;H0Y7C8 O14657 TOR1B Torsin-1B 0 16756000.0 3523100.0 6395700.0 6837200.0 False True 4560722.400683442 6039773.672727863 5592899.755596305 1.0 1.3243019728240375 1.226318829393823 22.120830929095476 -10.090308145859275 4.289645361139255 0.9999685818593134 1.2753104011128424 0.913242890510258 0.04000145096008293 5836052.673566209 6863921.1860117465 1491.8384345165912 0.013693562030844887 8.122539914074671e-11 10.090308145859275 0.2753418192535291 KPLTLSLHGWTGTGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPLTLSLHGWTGTGK 15 1 A0A494BZT7;O14656;O14656-2 A0A494BZT7 TOR1A Torsin-1A 0 19140800.0 6432900.0 4393300.0 8314600.0 False True 9759179.607985254 3609281.2899904293 6671215.665581368 1.0 0.3698344978749245 0.6835836549337383 23.218328444034704 -10.552621924794332 6.468605100746958 1.0006042491897809 0.5267090764044124 0.7521132612316517 0.12808755700373878 0.0011175173293124757 7.72891104345187e-05 0.12416848523146051 0.04134008126098949 2.801419034675983e-11 10.552621924794332 -0.4738951727853684 KPLTLSLHGWTGTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPLTLSLHGWTGTGK 15 1 A0A494BZT7;O14656;O14656-2 A0A494BZT7 TOR1A Torsin-1A 0 12980300.0 2367500.0 4511200.0 6101600.0 False True 3242828.729281826 4311880.267456524 4660527.7463965425 1.0 1.3296663584238864 1.437179738884541 21.628821398871597 -12.555496019064012 0.17619696391669615 4.865614455949258e-08 1.5326590586776463 0.9994807836393677 0.004238259401783375 6.835654462977347 0.12100323353051459 2.4952356998039598 0.08244907306074091 2.7829408834070667e-13 12.555496019064012 1.5326590100215016 KPLTLSLHGWTGTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPLTLSLHGWTGTGK 15 1 A0A494BZT7;O14656;O14656-2 A0A494BZT7 TOR1A Torsin-1A 0 5216940.0 2727300.0 995440.0 1494200.0 False True 2267870.789875864 990077.367140631 1806630.3115997852 1.0 0.4365669206378484 0.7966195956422519 21.11290701554985 -10.133329806627076 5.352990097811131 1.0000087979761858 0.6165932581398968 0.6018966769139252 0.1469908890480841 1.5434011927036078e-05 2.4988632275899415e-06 0.1423265806697777 0.04744110544386829 7.356482282971732e-11 10.133329806627076 -0.38341553983628895 KPLTLSLHGWTGTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPLTLSLHGWTGTGK 15 1 A0A494BZT7;O14656;O14656-2 A0A494BZT7 TOR1A Torsin-1A 0 25261000.0 6432900.0 10450000.0 8378100.0 False True 8327515.861416524 9868448.313711725 6853371.766565468 1.0 1.1850410708233807 0.8229791309457438 22.989454766127153 -6.767788268504146 1.583029713032743 1.106434597106128 0.8211159470421974 0.7219909975327012 0.07794211597748103 0.27002015784689354 1.3350991863040647 0.03881785215833009 0.09258723981349633 1.706914357773551e-07 6.767788268504146 -0.28531865006393065 KPLTSNCTIQIATPGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPLTSNCTIQIATPGK 16 1 Q15061;C9IZK7 Q15061 WDR43 WD repeat-containing protein 43 0 16195700.0 3919900.0 4243900.0 8031900.0 False True 5139026.860365592 3610726.6625926313 7200836.035425138 1.0 0.702609027098131 1.4012061487674086 22.293063762081168 -6.791037844451086 1.4920662872310881 0.8340062539442296 1.4088596337512924 0.8046671059318253 0.126511924400305 0.23383039527235341 1.0283555178859578 0.06673316083752415 0.15612930851800969 1.6179390441802412e-07 6.791037844451086 0.5748533798070629 KPLTSNCTIQIATPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPLTSNCTIQIATPGK 16 1 Q15061;C9IZK7 Q15061 WDR43 WD repeat-containing protein 43 0 11494100.0 3919900.0 3217600.0 4356600.0 False True 5369192.961314391 3075435.792819673 3327660.806993444 1.0 0.5727929346139199 0.6197692709071169 22.35627382360406 -10.561300033518332 9.794585713734033 1.000020379553085 0.5962811030263069 0.9899475111489586 0.01917800898395319 8.535089358437901e-06 3.822934447214131e-07 0.018569960911998452 0.006189675784022242 2.7459964185919628e-11 10.561300033518332 -0.4037392765267782 KPLTSSSAAPQRPISTQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPLTSSSAAPQRPISTQR 18 2 Q15691 Q15691 MAPRE1 Microtubule-associated protein RP/EB family member 1 0 5432830.0 1376400.0 931030.0 3125400.0 False True 1332706.93540327 1302795.134257309 2306763.980009786 1.0 0.9775556047985074 1.7308861526347288 20.34592813345361 -6.900035169789071 0.9610676338481051 0.9687085732610621 1.810010976945654 0.9865828624298278 0.04053590856631894 0.11137938251915197 0.17728464322173626 0.03163222120352153 0.08231416822975136 1.2588234663393912e-07 6.900035169789071 0.841302403684592 KPLTYQTK(ub)QLIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPLTYQTKQLIAR 13 2 E7EXA6;Q8WVB6;Q8WVB6-2;A0A0D9SF58;Q8WVB6-3 E7EXA6 CHTF18 Chromosome transmission fidelity protein 18 homolog 1 5640500.0 1832700.0 2320100.0 1487700.0 True False 2402687.447892045 1973950.1236789674 1333767.07502608 1.0 0.8215592608230327 0.5551146805200304 21.196217557906998 -6.965332860270144 0.35229363630244404 1.0250785799857176 0.3425728196782877 0.9999198416795448 0.0016366584083920375 0.07784819130168068 0.014462736424626057 0.0036365907548598355 0.022867231580887482 1.0830964683406709e-07 6.965332860270144 -0.6825057603074299 KPLTYQTK(ub)QLIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPLTYQTKQLIAR 13 2 E7EXA6;Q8WVB6;Q8WVB6-2;A0A0D9SF58;Q8WVB6-3 E7EXA6 CHTF18 Chromosome transmission fidelity protein 18 homolog 1 6004000.0 2041400.0 1336200.0 2626400.0 True False 1976596.8744058663 1869751.6281909475 1938467.0496889052 1.0 0.9459448471266885 0.9807093569707165 20.914587233715196 -10.0312375228944 4.696818444499986 1.0000010324741913 0.9633271020474362 0.5973808690287343 0.014192551716953036 1.5357738022241844e-07 3.1675432145812086e-08 0.013742266235079946 0.004580626369384738 9.305987762737925e-11 10.0312375228944 -0.03667393042675504 KPLTYQTK(ub)QLIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPLTYQTKQLIAR 13 2 E7EXA6;Q8WVB6;Q8WVB6-2;A0A0D9SF58;Q8WVB6-3 E7EXA6 CHTF18 Chromosome transmission fidelity protein 18 homolog 1 4061500.0 1832700.0 758100.0 1470700.0 True False 2510298.7168552494 724604.635298545 1123350.9500172741 1.0 0.2886527529306496 0.4474969223680839 21.25942761942989 -10.287396875391089 8.42009518424054 1.0000006316543761 0.3680748376599643 0.9547556092638838 0.06484786062298474 7.689262899385788e-07 6.505971775628672e-08 0.06278873420267082 0.020929557019166642 5.159446632326442e-11 10.287396875391089 -0.6319257939944118 KPLTYQTK(ub)QLIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPLTYQTKQLIAR 13 2 E7EXA6;Q8WVB6;Q8WVB6-2;A0A0D9SF58;Q8WVB6-3 E7EXA6 CHTF18 Chromosome transmission fidelity protein 18 homolog 1 5353100.0 2041400.0 1620500.0 1691200.0 True False 1697514.5493537893 1611770.0448559332 2044822.1007747003 1.0 0.9494882064306917 1.2045976875739441 20.694992509149472 -6.855272069459842 1.20942432854026 0.9728701461277103 1.21587906713564 0.9476238005379227 0.02524282265875441 0.15175496512902664 0.4245183282683307 0.016307437527544325 0.037885315467306745 1.3954938617775354e-07 6.855272069459842 0.2430089210079298 KPLVIIAEDVDGEALSTLVLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPLVIIAEDVDGEALSTLVLNR 22 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 49943900.0 6837900.0 32884000.0 10222000.0 False True 10373594.217451273 27015593.276135337 8201617.219538244 1.0 2.6042654753824466 0.7906244496956361 23.306412506413178 -6.673234898834096 1.9259205682299059 2.0211262553703935 0.7978412922846109 0.2934832359260372 0.6809513723882555 0.4537106996918973 3.247469591343668 0.28433636799950157 0.7564814097504439 2.122096363615921e-07 6.673234898834096 -1.2232849630857827 KPLVIIAEDVDGEALSTLVLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPLVIIAEDVDGEALSTLVLNR 22 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 19368000.0 6837900.0 6406300.0 6123800.0 False True 8851796.345160034 6049783.773409702 5009331.23549416 1.0 0.6834526617546494 0.5659112614168029 23.077538828505627 -13.999999999999998 0.1375985436906556 2.5091948040340064 0.4161514633020809 0.999612678839329 0.0036077919069615323 11.932354324650076 0.1160385580704976 4.842189953910076 0.1336794268348886 1.0000000000000041e-14 13.999999999999998 -2.0930433407319256 KPMVVLGSSALQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPMVVLGSSALQR 13 1 B4DJ81;P28331-3;P28331-4;P28331-5;P28331;P28331-2 B4DJ81 NDUFS1 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial 0 7278600.0 2235800.0 2057000.0 2985800.0 False True 2931155.451517996 1750103.6181231993 2676858.0578160044 1.0 0.5970695335236657 0.9132432933332502 21.483038051574432 -9.841359912479964 6.226843103911662 1.0000000149354633 0.7551564134283623 0.4443162802958087 0.12907739693213685 2.6776717013327036e-08 5.084368245564014e-09 0.12497865962164444 0.04165955072411394 1.4409207236312544e-10 9.841359912479964 -0.24484360150710105 KPNEGADGQWK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPNEGADGQWKK 12 2 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 6779000.0 1938900.0 3708800.0 1131300.0 True False 2541916.6763343066 3155461.4967891714 1014243.9281958744 1.0 1.2413709411355123 0.3990075432600386 21.27748530910469 -6.830090799880437 1.3275029556656832 1.1289570441139156 0.37629303520078566 0.9060816247594873 0.10854413909085249 0.1806778050983663 0.6226799952161256 0.06419998333516815 0.14774202808973624 1.4787991767190088e-07 6.830090799880437 -0.75266400891313 down KPNEGADGQWK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPNEGADGQWKK 12 2 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 11456600.0 4072700.0 4750300.0 2633600.0 True False 3943414.367783271 6647119.5624872465 1943781.153693535 1.0 1.6856254358640534 0.4929183120023477 21.911013883862385 -6.75080462592222 1.6467588791289787 1.402762216275426 0.49038555742256834 0.6524719663795682 0.2881171406358155 0.2986426168767401 1.5936313635714734 0.13819373690851935 0.33522831821751775 1.7749878069761434e-07 6.75080462592222 -0.9123766588528577 KPNEGADGQWK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPNEGADGQWKK 12 2 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 5686900.0 1938900.0 2660000.0 1088000.0 True False 2655763.7268023356 2542472.404556294 831036.808063368 1.0 0.9573413398553908 0.3129182011473496 21.340695370627582 -6.920340134261766 0.8222115998580619 1.0140455259049372 0.2081858209110668 0.9942745767869905 0.023783619290987535 0.09797225267918046 0.10458425007667488 0.02052892602747943 0.061694192807024366 1.2013232040706853e-07 6.920340134261766 -0.8058597049938705 down KPNEGADGQWK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPNEGADGQWKK 12 2 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 9358760.0 4072700.0 4504000.0 782060.0 True False 3386630.5012017125 4479736.058025997 945585.1301631153 1.0 1.3227708356244967 0.27921118935992095 21.69141915929666 -6.823639687904946 1.3560536972233552 1.1733596096971397 0.2546008153736996 0.8925524896716933 0.14299535016559115 0.18879224120349453 0.6811467565753461 0.08284325866286914 0.19078046238935392 1.5009295641874436e-07 6.823639687904946 -0.9187587943234401 down KPPKPQLMANYYNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPPKPQLMANYYNK 14 2 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 7134900.0 1997700.0 2306400.0 2830800.0 False True 1661176.063115539 2293974.9654154438 3422707.191859636 1.0 1.3809342768358275 2.060412058575141 20.66377355768922 -6.962219778508743 0.4029304921807972 0.9638343760345494 2.5024402016015923 0.9998438737547777 0.005480238442239896 0.07891749883279504 0.018269962575172584 0.008741147546479327 0.056868160775844306 1.0908881432841955e-07 6.962219778508743 1.538605825567043 up KPPKPQLMANYYNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPPKPQLMANYYNK 14 2 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 16624500.0 2044900.0 5307900.0 9271700.0 False True 2647163.3610052476 5012510.698980902 7584345.7356757615 1.0 1.8935403733743978 2.86508413020481 21.33601579809775 -6.970054001157548 0.2568917543787359 0.7166761607938427 4.070656405558241 0.9999828013113055 0.003158612251246894 0.07628517169769321 0.008967364250545173 0.02069572211724411 0.09210068745976706 1.0713860783881937e-07 6.970054001157548 3.353980244764398 KPPLLNNADSVQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPPLLNNADSVQAK 14 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 9061200.0 2047900.0 1005800.0 6007500.0 False True 1982890.5354637865 1407421.1851777094 4433955.528863126 1.0 0.7097825926374306 2.2361070616669467 20.919173605790316 -6.8574830586260935 1.198414125862852 0.84348026860526 2.3065355171835313 0.9505066001067016 0.14723213578673838 0.14941427277177016 0.40920347265933454 0.09591612004555856 0.22329645006887283 1.3884074691971944e-07 6.8574830586260935 1.4630552485782713 up KPPPVPALPSK(ub)LPTFGAPEQLVDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPPPVPALPSKLPTFGAPEQLVDLK 25 2 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 14359600.0 4721100.0 6305400.0 3333100.0 True False 3925803.8301921035 6271431.558676094 4030035.7994868457 1.0 1.5974897957061727 1.0265504782722783 21.904556653417128 -10.453366093114756 5.5715857724369835 0.9997190914715794 1.3120201369892261 0.2848054408186328 0.2330850003009949 0.0008140386432314587 7.986580008017715e-05 0.2258838097432389 0.07522786036804158 3.5207396145880703e-11 10.453366093114756 0.3123010455176467 KPPTDEELKETIK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPPTDEELKETIKK 14 3 H0Y993;P35659;A0A494C028;P35659-2;B4DFG0;A0A494C198 H0Y993 DEK Protein DEK 1 5109800.0 2045800.0 1806700.0 1257300.0 True False 2682063.6115553807 1537147.402461441 1127206.6568732196 1.0 0.5731211578423449 0.42027588459004916 21.354912023936876 -13.999999999999991 0.143003297777361 3.0451840241908785 0.23779511304750844 0.9995912363481577 0.0049599909597968575 11.93824828164754 0.11869044463154384 6.80260823018696 0.16348677491359168 1.0000000000000205e-14 13.999999999999991 -2.80738891114337 KPPTDEELKETIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPPTDEELKETIKK 14 3 H0Y993;P35659;A0A494C028;P35659-2;B4DFG0;A0A494C198 H0Y993 DEK Protein DEK 1 7426500.0 2538200.0 1977500.0 2910800.0 True False 2457626.2303404342 2767126.0625262656 2148374.157871787 1.0 1.1259344599943333 0.8741663526166836 21.22883408851839 -6.770720186779023 1.5718714384485226 1.0721661134255869 0.8727171952157002 0.7332574324729504 0.05308493174437608 0.2652601841209314 1.2935819023396855 0.026619183527897352 0.0633184121072551 1.6954298034525725e-07 6.770720186779023 -0.19944891820988664 KPPTDEELKETIK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPPTDEELKETIKK 14 3 H0Y993;P35659;A0A494C028;P35659-2;B4DFG0;A0A494C198 H0Y993 DEK Protein DEK 1 14324900.0 5022200.0 4429100.0 4873600.0 True False 7619044.57200074 3638692.5002837502 3910330.8238252336 1.0 0.4775785816578101 0.5132311258809701 22.861178664462987 -10.091539606296422 5.518791439146553 1.0000048903446788 0.49540485376922244 0.9962697906137697 0.014555090230382674 8.757879512929378e-07 1.4418154923612223e-07 0.014093041961203794 0.004697635171982557 8.099540730376411e-11 10.091539606296422 -0.5046000365754564 KPPTDEELKETIK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPPTDEELKETIKK 14 3 H0Y993;P35659;A0A494C028;P35659-2;B4DFG0;A0A494C198 H0Y993 DEK Protein DEK 1 6494900.0 2045800.0 2616300.0 1832800.0 True False 2802187.5456662136 2500703.2150528734 1399930.3877008639 1.0 0.8924110803791103 0.49958482966850587 21.418122085459768 -6.946972994475017 0.5911437802623516 1.0045252854244686 0.36766531405186254 0.998941811397535 0.006996244883469195 0.08472452201022569 0.041171978635137906 0.007244739633680963 0.03292038209781125 1.1298661704133331e-07 6.946972994475017 -0.6368599713726061 down KPPTDEELKETIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPPTDEELKETIKK 14 3 H0Y993;P35659;A0A494C028;P35659-2;B4DFG0;A0A494C198 H0Y993 DEK Protein DEK 1 7188800.0 2538200.0 3386600.0 1264000.0 True False 2110625.7613254543 3368355.713612531 1528296.555924324 1.0 1.595903819300127 0.7240964191418603 21.009239363952666 -6.7227077770928405 1.749502836761317 1.361493278169586 0.7252414509707822 0.5252440733642184 0.25067987113194395 0.3501098437105686 2.0956611043331947 0.1137059901227852 0.28454695722837114 1.8936173447956497e-07 6.7227077770928405 -0.6362518271988039 KPQDETK(ub)ESTSCPVVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPQDETKESTSCPVVQK 17 2 Q9H8H0 Q9H8H0 NOL11 Nucleolar protein 11 1 26699300.0 9236900.0 12806000.0 4656400.0 True False 12109665.350266855 10895394.71739703 4174600.3953427635 1.0 0.899727152010599 0.3447329281688837 23.529655661020705 -6.937567077478403 0.6818301370332173 1.0065695078146009 0.2052096176168917 0.9978274232865257 0.013432498670957334 0.08889456137487474 0.05979877302813278 0.012845911698371642 0.04830165586546988 1.1546036405352646e-07 6.937567077478403 -0.8013598901977091 down KPQDETK(ub)ESTSCPVVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPQDETKESTSCPVVQK 17 2 Q9H8H0 Q9H8H0 NOL11 Nucleolar protein 11 1 61395700.0 23293000.0 30370000.0 7732700.0 True False 35337183.946400575 24950236.21810697 6204328.455637191 1.0 0.7060618145450265 0.17557506747136145 25.074683738949993 -7.252619977420598 0.49649872093054415 1.011495905343346 5.0230542697282606e-21 0.9988698853102251 0.011468731175676287 0.0944250356491159 0.04238243354072362 0.012869590526466537 0.05233590706315624 5.589590891959809e-08 7.252619977420598 -1.011495905343346 down KPQDETK(ub)ESTSCPVVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPQDETKESTSCPVVQK 17 2 Q9H8H0 Q9H8H0 NOL11 Nucleolar protein 11 1 24814300.0 9236900.0 12266000.0 3311400.0 True False 12652031.547836684 11724047.56176222 2529315.5204237425 1.0 0.926653361354198 0.1999137854549706 23.592865722543596 -6.926346944854819 0.7761939287646491 1.0126760104584276 0.0637106971770781 0.99577020878675 0.023486096788083506 0.09457964664533039 0.08730222787077102 0.020948997411706027 0.06712669641359886 1.1848218513012105e-07 6.926346944854819 -0.9489653132813495 down KPQDETK(ub)ESTSCPVVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPQDETKESTSCPVVQK 17 2 Q9H8H0 Q9H8H0 NOL11 Nucleolar protein 11 1 18636000.0 9459100.0 5762600.0 3414300.0 True False 7865660.75918115 5731555.730013463 4128214.3440604615 1.0 0.728680768913576 0.5248401209322212 22.907136534450526 -7.295441050236358 0.1359205520932194 1.3136097048182778 5.2671764743436584e-11 0.999996127724582 0.0003829594558330708 0.10757731358171022 0.007801107404993477 0.025327323944418993 0.04671317031929065 5.064760923261323e-08 7.295441050236358 -1.313609704765606 KPQDETK(ub)ESTSCPVVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPQDETKESTSCPVVQK 17 2 Q9H8H0 Q9H8H0 NOL11 Nucleolar protein 11 1 76316900.0 23293000.0 44522000.0 8501900.0 True False 30153247.673673596 42044311.56201659 6954641.436860732 1.0 1.3943543334711812 0.23064319678350062 24.845810061042442 -6.815274393411419 1.3921024971473372 1.2136319589658042 0.20770784201955209 0.8731657481193869 0.17209850478904182 0.1997103363264668 0.7617089093591239 0.09717459134820233 0.22431248431965675 1.530120404447242e-07 6.815274393411419 -1.005924116946252 down KPSISITTESLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPSISITTESLK 12 1 S4R3H4;E7EQT4;Q9UKV3-5;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2;G3V3T3 S4R3H4 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 0 28021900.0 9767800.0 5112100.0 13142000.0 False True 12805680.391509755 4349394.606809728 11782191.906965615 1.0 0.3396457254776875 0.9200754311170597 23.61028057246745 -10.501454203339486 8.904780602722557 1.0000134562610072 0.6298605782973998 0.35158125911772786 0.23695943506171693 6.330540218207148e-05 3.543967909924365e-06 0.22944331110526314 0.07647832881006227 3.1517067123854895e-11 10.501454203339486 -0.3701528779636074 KPSISITTESLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPSISITTESLK 12 1 S4R3H4;E7EQT4;Q9UKV3-5;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2;G3V3T3 S4R3H4 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 0 11698400.0 3226100.0 1493600.0 6978700.0 False True 3123689.221377858 2090002.2690211025 5150769.113487653 1.0 0.6690813717054744 1.6489377618736512 21.57481949492953 -6.815606123176019 1.3908359652047442 0.8208081546463705 1.6683688871282734 0.8739650860157656 0.1444860744369741 0.1992528951105653 0.7585278796608559 0.08165990208090025 0.18846343935785925 1.52895208963862e-07 6.815606123176019 0.8475607324819029 KPSISITTESLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPSISITTESLK 12 1 S4R3H4;E7EQT4;Q9UKV3-5;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2;G3V3T3 S4R3H4 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 0 16144500.0 3026800.0 10382000.0 2735700.0 False True 4591876.888720449 8529250.985063765 2194987.6959000966 1.0 1.8574650827453882 0.47801536258341226 22.130652532240777 -6.738575305337756 1.6917933523408613 1.5110136501626388 0.4774323136246949 0.598626485906135 0.3602832355504992 0.32037696186901404 1.799902824160863 0.16850670716660113 0.414167796556535 1.8256801542604452e-07 6.738575305337756 -1.0335813365379438 KPSISITTESLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPSISITTESLK 12 1 S4R3H4;E7EQT4;Q9UKV3-5;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2;G3V3T3 S4R3H4 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 0 23107500.0 9767800.0 5562100.0 7777600.0 False True 13379219.624869708 5316348.030594959 5940691.064700043 1.0 0.3973586038391033 0.4440237346621698 23.67349063399034 -9.9618494111984 7.29158088128384 1.0000000156010433 0.4206911715369841 0.995156965439262 0.01905095988279069 4.8561863727750215e-09 6.785368848264138e-10 0.018446013413427827 0.006148670862942697 1.0918188519436184e-10 9.9618494111984 -0.5793088440640592 KPSISITTESLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPSISITTESLK 12 1 S4R3H4;E7EQT4;Q9UKV3-5;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2;G3V3T3 S4R3H4 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 0 7371100.0 3226100.0 2320600.0 1824400.0 False True 2682645.0904625524 2308098.4671969633 2205873.604927482 1.0 0.8603815970300386 0.8222756013346277 21.355224770363808 -13.999995227561149 0.18222151766165776 1.7294337169185234 0.7926902761629118 0.999495622026167 0.0017157876243145832 12.234210256806007 0.13533934997668765 3.1613094080770514 0.027922991847710743 1.0000109890069348e-14 13.999995227561149 -0.9367434407556117 KPSVHVVMNLPAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPSVHVVMNLPAK 13 1 Q32P41 Q32P41 TRMT5 tRNA (guanine(37)-N1)-methyltransferase 0 9377900.0 2224300.0 3355600.0 3798000.0 False True 2916078.8401518394 2854957.5600263504 3405019.3929885356 1.0 0.9790399082206205 1.1676705533829932 21.475598294736102 -6.879326683957903 1.083604104418848 0.987123116673273 1.1808642923629689 0.9731357749846528 0.013836011409958137 0.12822554654446788 0.27593547221975717 0.00984213964692474 0.02375952438373552 1.320302106061951e-07 6.879326683957903 0.19374117568969584 KPTDGASSSNCVTDISHLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPTDGASSSNCVTDISHLVR 20 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YDS9 P49321 NASP Nuclear autoantigenic sperm protein 0 41608900.0 1194900.0 20015800.0 20398200.0 False True 1566525.471428062 17029520.66097733 18287589.937350918 1.0 10.870886539401768 11.67398186042883 20.57913679719094 -9.577520340190906 0.7134098756221006 1.0112348689924546e-20 11.538038917624002 0.9993300613724243 0.12562548694114936 0.8960786903042159 0.3475653727324158 2.66306738298462 0.12298969280781677 2.645328797794585e-10 9.577520340190906 11.538038917624002 KPTDGASSSNCVTDISHLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPTDGASSSNCVTDISHLVR 20 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YDS9 P49321 NASP Nuclear autoantigenic sperm protein 0 16101200.0 8986800.0 2036300.0 5078100.0 False True 8701518.953125607 2849405.209164215 3747993.2702654717 1.0 0.3274606680182776 0.4307286222618849 23.0528358317642 -10.476224321422565 6.662121177444812 1.00020117238506 0.3790946451400813 0.9796753172953337 0.042158965779653106 0.00012601120134459997 9.906993568759979e-06 0.04083307744467312 0.013606747696493745 3.3402246645616284e-11 10.476224321422565 -0.6211065272449786 KPTDGASSSNCVTDISHLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPTDGASSSNCVTDISHLVR 20 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YDS9 P49321 NASP Nuclear autoantigenic sperm protein 0 37747400.0 1194900.0 22511500.0 14041000.0 False True 1636686.820958336 21516867.49442446 10724804.983472183 1.0 13.146600326277204 6.552753310002487 20.642346858713832 -9.580206778945364 8.305757128973092 1.0001095961413622 9.84967681813991 0.7060279362798956 2.6919267727183316 0.0 0.0 2.6064470061553413 0.8688156298836163 2.629015950697774e-10 9.580206778945364 8.849567221998548 KPTSQIPETK(ub)HPFSFPLENQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPTSQIPETKHPFSFPLENQAR 22 2 I3L1L3;Q9BQG0;Q9BQG0-2;I3L2H8 I3L1L3 MYBBP1A Myb-binding protein 1A 1 55571900.0 3796500.0 7771400.0 44004000.0 True False 4914644.09020314 7338914.7583903605 35995723.51916861 1.0 1.4932749195449913 7.32417706318196 22.228655512260172 -6.923612348518513 0.797482101478421 0.8873131659400805 8.347280247123349 0.9951268900046947 0.2004909869375952 0.09609252880083544 0.0949414130294519 0.1761349119090227 0.5472892929675973 1.1923057859599625e-07 6.923612348518513 7.459967081183269 up KPTVTLTYGSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPTVTLTYGSSR 12 1 Q6PJT7;Q6PJT7-5;Q6PJT7-9;Q6PJT7-2;Q6PJT7-11;Q6PJT7-10;Q6PJT7-3;Q6PJT7-4;G3V256;H0YJA2;G3V5I6;A0A3B3IT62;G3V3Y4;G3V3R9 Q6PJT7 ZC3H14 Zinc finger CCCH domain-containing protein 14 0 16131900.0 6495800.0 1386800.0 8249300.0 False True 8516056.705416676 1179894.8457040598 7395741.568873191 1.0 0.13854943508696724 0.868446726542943 23.02175412554358 -10.89480381248149 10.054624686799281 1.043472312958065 0.5034980808149552 0.3815555591659807 0.29797932145110606 0.15693408833147499 0.0016419153177022541 0.15592735064442942 0.09617241245785997 1.2740785012915703e-11 10.89480381248149 -0.5399742321431098 KPTVTLTYGSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPTVTLTYGSSR 12 1 Q6PJT7;Q6PJT7-5;Q6PJT7-9;Q6PJT7-2;Q6PJT7-11;Q6PJT7-10;Q6PJT7-3;Q6PJT7-4;G3V256;H0YJA2;G3V5I6;A0A3B3IT62;G3V3Y4;G3V3R9 Q6PJT7 ZC3H14 Zinc finger CCCH domain-containing protein 14 0 10064300.0 1073800.0 1177600.0 7812900.0 False True 1039712.806768403 1647821.8211028753 5766467.1080240905 1.0 1.5848817196208 5.5462114830990785 19.987753646277167 -6.93332822158136 0.7189468257859923 0.946563250087651 6.432964311447367 0.9971529079324984 0.10775213845457679 0.09094612645253501 0.06948128404203677 0.10018848361211298 0.3521027266959537 1.1659281243574547e-07 6.93332822158136 5.486401061359715 up KPTVTLTYGSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPTVTLTYGSSR 12 1 Q6PJT7;Q6PJT7-5;Q6PJT7-9;Q6PJT7-2;Q6PJT7-11;Q6PJT7-10;Q6PJT7-3;Q6PJT7-4;G3V256;H0YJA2;G3V5I6;A0A3B3IT62;G3V3Y4;G3V3R9 Q6PJT7 ZC3H14 Zinc finger CCCH domain-containing protein 14 0 8769460.0 6495800.0 916860.0 1356800.0 False True 8897472.802394459 876350.0935494304 1036351.7841731404 1.0 0.09849427056563634 0.11647709492230657 23.084964187066472 -10.066672035824825 4.81303673025221 1.0000283173087525 0.10748568273232205 0.9996956209559126 0.007341457346531876 82139039.60474254 169041974.97484335 36579.37515864399 0.0026866900033737343 8.576852950104746e-11 10.066672035824825 -0.8925426345764305 KPTVTLTYGSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPTVTLTYGSSR 12 1 Q6PJT7;Q6PJT7-5;Q6PJT7-9;Q6PJT7-2;Q6PJT7-11;Q6PJT7-10;Q6PJT7-3;Q6PJT7-4;G3V256;H0YJA2;G3V5I6;A0A3B3IT62;G3V3Y4;G3V3R9 Q6PJT7 ZC3H14 Zinc finger CCCH domain-containing protein 14 0 4877770.0 1073800.0 1436700.0 2367270.0 False True 892912.27740575 1428960.2119373775 2862255.211980203 1.0 1.6003366154725196 3.205527893844336 19.768158921711443 -6.954005745599751 0.5129869718226345 0.9711684973895168 3.9054776918067 0.9994792976541351 0.02124514349100067 0.08191601746084491 0.02960584491490083 0.024345949478041234 0.1325084898789728 1.1117170194656987e-07 6.954005745599751 2.934309194417183 KPTVTLTYGSSRPSIEIYRPPASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPTVTLTYGSSRPSIEIYRPPASR 24 3 Q6PJT7;Q6PJT7-5;Q6PJT7-9;Q6PJT7-2;Q6PJT7-11;Q6PJT7-10;Q6PJT7-3;Q6PJT7-4;G3V256;H0YJA2;G3V5I6;A0A3B3IT62;G3V3Y4;G3V3R9 Q6PJT7 ZC3H14 Zinc finger CCCH domain-containing protein 14 0 48780100.0 4883700.0 29293000.0 14603400.0 False True 6322045.922119087 27662818.79938352 11945731.043537557 1.0 4.375611809872969 1.8895356330365705 22.59196008406245 -6.567699082972824 2.315720949786391 3.315481917315569 1.8944206395511354 0.0 1.4710272776870965 0.737138222635148 7.41763319279708 0.5376347170232839 1.6501847419167324 2.7058325510978e-07 6.567699082972824 -1.4210612777644336 KPVAGALDVSFNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPVAGALDVSFNK 13 1 E9PGT6;Q99627-2;Q99627;H7C3S9 E9PGT6 COPS8 COP9 signalosome complex subunit 8 0 34290000.0 2241000.0 10425000.0 21624000.0 False True 2937972.7018748675 8869630.636331722 19386555.91205482 1.0 3.0189629163918257 6.598616760354271 21.48638956050335 -6.9623304763572476 0.4012401438811926 0.8058933792360775 8.94265554550172 0.9998471069948246 0.02862543381518982 0.07887889188847025 0.018130697580031854 0.04605365285025318 0.2997788466910734 1.0906101209132946e-07 6.9623304763572476 8.136762166265642 KPVAGALDVSFNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPVAGALDVSFNK 13 1 E9PGT6;Q99627-2;Q99627;H7C3S9 E9PGT6 COPS8 COP9 signalosome complex subunit 8 0 11531600.0 2241000.0 2197700.0 7092900.0 False True 3069558.2607478644 2100598.347177961 5417703.102860894 1.0 0.6843324572266541 1.7649780986860728 21.549599622026243 -6.828516194468411 1.3344569179000507 0.8311406634998484 1.7931984447572364 0.9028769712485619 0.14139514311187254 0.18265795612949276 0.6366591353426665 0.08320361829955086 0.19149670762450413 1.4841705355875172e-07 6.828516194468411 0.9620577812573881 KPVAGALDVSFNK(ub)FIPLSEPAPVPPIPNEQQLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KPVAGALDVSFNKFIPLSEPAPVPPIPNEQQLAR 34 2 E9PGT6;Q99627-2;Q99627;H7C3S9 E9PGT6 COPS8 COP9 signalosome complex subunit 8 1 112201600.0 67720000.0 30068600.0 14413000.0 True False 65570265.66805386 42075148.78567755 10637802.919268273 1.0 0.6416803158718444 0.1622351657551856 25.966538404386995 -7.460558007743213 0.4505596960808096 1.0229088010460576 6.002229319837907e-23 0.998363590091001 0.01388354395403229 0.11521406764988625 0.05466243065037599 0.018445402299766562 0.06518348605571465 3.4629162812042325e-08 7.460558007743213 -1.0229088010460576 down KPVAGALDVSFNK(ub)FIPLSEPAPVPPIPNEQQLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPVAGALDVSFNKFIPLSEPAPVPPIPNEQQLAR 34 2 E9PGT6;Q99627-2;Q99627;H7C3S9 E9PGT6 COPS8 COP9 signalosome complex subunit 8 1 259330000.0 146165000.0 69065000.0 44100000.0 True False 221742991.0928452 56739811.142692 35383615.67028334 1.0 0.2558809677052416 0.15957039045923213 27.724313263285218 -13.999999999999998 0.2882384999819775 7.348845627003535 0.13285651268135604 0.9996235217302202 0.007286727890751448 15.86184913986601 0.17021756098314236 59.65280584273884 0.03666583727119464 1.0000000000000041e-14 13.999999999999998 -7.215989114322179 KPVAGALDVSFNK(ub)FIPLSEPAPVPPIPNEQQLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KPVAGALDVSFNKFIPLSEPAPVPPIPNEQQLAR 34 2 E9PGT6;Q99627-2;Q99627;H7C3S9 E9PGT6 COPS8 COP9 signalosome complex subunit 8 1 109972700.0 67720000.0 35472000.0 6780700.0 True False 56312180.504672535 35280905.29535931 8198513.019585501 1.0 0.6265235155017991 0.14559040239802515 25.74694367982127 -7.5213088308682865 0.4587144524508886 1.0225684862970317 1.63578197306629e-26 0.9978984052845843 0.01603270642440119 0.11761613691667222 0.06235508998998132 0.021004034462652556 0.06868782529949735 3.0108642090425975e-08 7.5213088308682865 -1.0225684862970317 down KPVAGALDVSFNK(ub)FIPLSEPAPVPPIPNEQQLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KPVAGALDVSFNKFIPLSEPAPVPPIPNEQQLAR 34 2 E9PGT6;Q99627-2;Q99627;H7C3S9 E9PGT6 COPS8 COP9 signalosome complex subunit 8 1 264117000.0 146165000.0 87789000.0 30163000.0 True False 189213473.84289286 82903464.97726691 24673643.498515647 1.0 0.4381477877527002 0.13040109140960326 27.495439585377667 -8.666873165069038 0.31403723475422296 1.184025575061825 4.222409502262155e-18 0.9984895195557834 0.013992491486541525 0.25483233979860964 0.0956558494146965 0.14510946154561824 0.09348169113341022 2.1534105426174975e-09 8.666873165069038 -1.184025575061825 KPVIVFVPSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPVIVFVPSR 10 1 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 7959800.0 1847100.0 1828600.0 4284100.0 False True 2421565.9873418426 1555780.0078269716 3840822.4279889935 1.0 0.6424685579329408 1.5860903432183862 21.20750888604184 -6.804011954233574 1.4392734317691465 0.8037307645548819 1.6004784349231094 0.8437109404649158 0.15377727326192747 0.21506393698574947 0.8790413375037152 0.08403467913472136 0.19499396947825942 1.5703195796871866e-07 6.804011954233574 0.7967476703682275 KPVIVFVPSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPVIVFVPSR 10 1 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 5133700.0 1847100.0 1723900.0 1562700.0 False True 2530022.7860006164 1647732.3978250376 1193622.4448167488 1.0 0.6512717620340974 0.4717832785623212 21.27071894756473 -13.663684866342766 0.08788941506659971 2.7137951169390875 2.5718093509307987e-19 0.999863304241208 0.002564006144136515 10.835549592180993 0.0819177745407911 3.6007636729373105 0.411099445901959 2.1692776095566752e-14 13.663684866342766 -2.7137951169390875 KPVIYLSAAARPGLGQYLCNQLGLPFPCLCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KPVIYLSAAARPGLGQYLCNQLGLPFPCLCR 31 2 Q6P996;Q6P996-5;Q6P996-4;Q6P996-3;H3BND4;Q86XE2;J3KNK7;Q6P474 Q6P996 PDXDC1;PDXDC2P Pyridoxal-dependent decarboxylase domain-containing protein 1;Putative pyridoxal-dependent decarboxylase domain-containing protein 2 0 78074000.0 25975000.0 24816000.0 27283000.0 False True 39405974.026864536 20387390.91170704 21890503.091436274 1.0 0.5173680238891745 0.5555122955852505 25.23191102601482 -10.019710620495454 6.216660409974089 1.0000003732326253 0.5364401607826474 0.9949474744048381 0.015572333710964803 8.054550323263332e-08 1.2721715323048769e-08 0.015077859413160723 0.005025949093671525 9.556291296203413e-11 10.019710620495454 -0.4635602124499778 KPVTDCVISVPSFFTDAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPVTDCVISVPSFFTDAER 19 1 Q92598-2;Q92598;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 9562640.0 774040.0 6024000.0 2764600.0 False True 1014773.9358140236 5125242.681368092 2478545.7119157766 1.0 5.050625070752102 2.442460950603304 19.952726939094127 -9.537288943424539 8.921196510700742 1.0000000000000757 3.7465430106777093 0.5965414561214442 1.0647785432999537 0.0 2.1378248591828535e-17 1.030967391399919 0.3436557971333062 2.9020912019259663e-10 9.537288943424539 2.746543010677634 KPVTDCVISVPSFFTDAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPVTDCVISVPSFFTDAER 19 1 Q92598-2;Q92598;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 13137340.0 774040.0 5156100.0 7207200.0 False True 1060223.5056444807 4928286.453057414 5505007.796943296 1.0 4.648346718234325 5.192308760969182 20.01593700061702 -9.759522381066258 0.4976090974890381 4.2079215427970677e-19 5.183355121619558 0.9988817425159997 0.062244374955721694 1.049593037300095 0.2214857132566113 1.8732438732867664 0.11040140613345191 1.739713040817755e-10 9.759522381066258 5.183355121619558 KPVVDCVVSVPCFYTDAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KPVVDCVVSVPCFYTDAER 19 1 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 0 12209400.0 1804300.0 6960900.0 3444200.0 False True 2365454.772866054 5922360.853375678 3087827.223099299 1.0 2.5036880524246814 1.3053841732759055 21.173686146328635 -6.58947987727965 2.230679473384617 2.018056524276191 1.3088286370599984 0.0 0.6516848026449659 0.6711317089821942 6.294938971852745 0.24394943783932516 0.7265380139876102 2.5734760018108134e-07 6.58947987727965 -0.7092278872161926 KPVVDCVVSVPCFYTDAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KPVVDCVVSVPCFYTDAER 19 1 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 0 16565800.0 1804300.0 7667300.0 7094200.0 False True 2471398.469374107 7328533.333629512 5418696.069635242 1.0 2.9653386228265717 2.1925626873951862 21.236896207851526 -10.430727589594712 5.887346982849262 0.9992971472539998 2.5789506551108796 0.8477078458595939 0.31548445455147883 0.0029115028716880337 0.00028152548804683203 0.30557449033366135 0.10182216987210019 3.709133035108548e-11 10.430727589594712 1.5796535078568799 KQDEWIK(ub)FDDDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQDEWIKFDDDK 12 2 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 13212900.0 5220900.0 2772400.0 5219600.0 True False 6844650.459267515 2358768.726730556 4679525.861938652 1.0 0.3446149282227893 0.6836763819842211 22.706545437533812 -10.619765123103448 6.671988254108943 1.0014111833977224 0.5141456551037118 0.7324594983291305 0.1384212588602967 0.0029127179754329154 0.00016599482496664853 0.13435180107337563 0.04467526919391624 2.4001306164130343e-11 10.619765123103448 -0.4872655282940106 KQDEWIK(ub)FDDDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQDEWIKFDDDK 12 2 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 12404300.0 3175800.0 5298200.0 3930300.0 True False 2640818.4117947286 5269657.544989644 4752107.558346027 1.0 1.9954638007118133 1.7994828940610283 21.332553671506936 -10.216181155853683 4.779455817194167 0.9998390118069908 1.8974733473891459 0.9654709306744581 0.08000887011311401 0.00013727421474468287 2.251250804756823e-05 0.07748190105805715 0.02582275179008247 6.078813847897969e-11 10.216181155853683 0.8976343355821551 KQDEWIK(ub)FDDDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQDEWIKFDDDK 12 2 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 12778800.0 4694900.0 4155800.0 3928100.0 True False 6077640.600314697 3924526.0767582036 3213226.105709622 1.0 0.6457318447811793 0.5286963012494097 22.53507993331334 -13.999999999999998 0.15479899837593689 2.726929879682609 0.40677701393238214 0.9995510197206774 0.0042456504978872975 11.979027812249116 0.12413795049898194 6.215383285940371 0.11043851634329639 1.0000000000000041e-14 13.999999999999998 -2.320152865750227 KQDEWIK(ub)FDDDKVSIVTPEDILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQDEWIKFDDDKVSIVTPEDILR 23 3 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 20182400.0 1803300.0 3125100.0 15254000.0 True False 1746055.2285765163 4372968.727181211 11258519.78980907 1.0 2.504484769789501 6.447974614747815 20.735667762159405 -6.954439849900788 0.5077708896325673 0.9260720970316286 8.198737341107782 0.999505204251269 0.051099391934559986 0.08175044604321942 0.028952178766568974 0.059085516034928905 0.32541982471760805 1.110606344462387e-07 6.954439849900788 7.272665244076153 KQDEWIK(ub)FDDDKVSIVTPEDILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQDEWIKFDDDKVSIVTPEDILR 23 3 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 18219500.0 1803300.0 14169600.0 2246600.0 True False 1499523.8497353236 14093265.552354598 2716353.672895244 1.0 9.39849376509894 1.8114774722487403 20.51607303759368 -6.62186754148878 2.1098520534690812 6.5653337869513315 1.8407035267136527 0.08909662154306641 3.6099289619664376 0.5804273369465629 4.912275438802562 1.4046090608255206 4.002081033874573 2.3885396692473883e-07 6.62186754148878 -4.724630260237679 KQDEWIK(ub)FDDDKVSIVTPEDILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQDEWIKFDDDKVSIVTPEDILR 23 3 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 26781200.0 8079300.0 10153000.0 8548900.0 True False 10458813.116812408 9587976.624795703 6993087.919121461 1.0 0.9167365854719359 0.6686311191353216 23.31821580569667 -6.951602587857653 0.5409624437934195 1.0036298051406651 0.57026144048064 0.9993211285359714 0.003667253242531801 0.08284850678173644 0.03334778647802175 0.004028251941472527 0.020549829859905125 1.1178857294763856e-07 6.951602587857653 -0.43336836466002515 KQDPDTWENELPVSK(ub)YANNLTQLDNGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQDPDTWENELPVSKYANNLTQLDNGVR 28 2 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 40152500.0 17437000.0 8793500.0 13922000.0 True False 16883471.979531232 12304790.407496708 10275410.548952542 1.0 0.7288068723313834 0.6086076703541778 24.00910827990243 -13.99999999999998 0.11028677682556462 2.3078844785424315 0.3890143050860509 0.9997416053250024 0.002631427994492789 12.010941361975103 0.10082095640377722 3.496063001924754 0.1950302400335186 1.000000000000045e-14 13.99999999999998 -1.9188701734563807 KQDPDTWENELPVSK(ub)YANNLTQLDNGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQDPDTWENELPVSKYANNLTQLDNGVR 28 2 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 41552000.0 17437000.0 10576000.0 13539000.0 True False 14499638.090076415 10519024.988828355 16369942.30273691 1.0 0.7254681064093317 1.1289897169185579 23.789513555336708 -6.723522667859025 1.7465985223778426 0.8336064092648355 1.128489344854493 0.5290479042606047 0.11547748837505632 0.34854706356394866 2.079809340778732 0.052458335481467284 0.13114963039732086 1.8900675771507563e-07 6.723522667859025 0.2948829355896575 KQDPDTWENELPVSK(ub)YANNLTQLDNGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQDPDTWENELPVSKYANNLTQLDNGVR 28 2 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 97194000.0 18653000.0 32870000.0 45671000.0 True False 24146676.205599718 31040755.60494784 37359346.624033034 1.0 1.285508421144495 1.5471838155252706 24.52532127970262 -6.972167457267339 0.19974352738101878 0.8437281420543704 1.996186930698579 0.9999947189142324 0.0005134865261635905 0.07560547669120943 0.006447400418611834 0.008513705085108212 0.027798093474233516 1.0661849374616643e-07 6.972167457267339 1.1524587886442088 KQDPEWK(ub)PK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQDPEWKPK 9 2 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 4231000.0 1269100.0 1793400.0 1168500.0 True False 1663802.389981881 1525831.7106184456 1047594.8290434735 1.0 0.9170750804337179 0.6296389735651732 20.666052663907358 -6.9481674757836105 0.5786228636781476 1.0034538674405937 0.5290769953294467 0.9990494320509302 0.004892836190179789 0.08423027685907872 0.03907452558851606 0.005134082373731763 0.024002182397807565 1.126762861929494e-07 6.9481674757836105 -0.474376872111147 KQDPEWK(ub)PK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQDPEWKPK 9 2 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 4992000.0 1653300.0 2328600.0 1010100.0 True False 1374792.2036086102 2316055.369609091 1221307.2398252853 1.0 1.6846584985933257 0.8883576998906079 20.390782144704566 -6.679165318955326 1.904762614361073 1.4335205326915537 0.8914064388507469 0.32028712011841853 0.2902287992254696 0.4404178142163997 3.088610888579452 0.1222928714050071 0.3228952703622051 2.093315460690749e-07 6.679165318955326 -0.5421140938408068 KQDPEWK(ub)PK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQDPEWKPK 9 2 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 7948000.0 1927400.0 4031100.0 1989500.0 True False 2495057.2947339765 3806765.741378312 1627431.4139938625 1.0 1.5257227757506027 0.6522621414060071 21.250641514297335 -6.743751461183525 1.6731091216925913 1.3114451091308421 0.651337617987667 0.6215592467228328 0.2208775234825096 0.3110920548358307 1.7112864272619521 0.10438199354362862 0.2550822467621263 1.8040498703568652e-07 6.743751461183525 -0.6601074911431751 KQDPEWKPK(ub)TAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQDPEWKPKTAK 12 3 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 6672600.0 1907000.0 2547100.0 2218500.0 True False 2500095.4674142683 2167082.608518039 1988950.9013546775 1.0 0.8667999429475192 0.7955499809020319 21.253551755305715 -13.999999999806258 0.07747281550678904 1.7297694080734733 0.5724644907663996 0.9998968987574693 0.0008603591182723219 12.283769081131982 0.07757294985414272 1.5548193647820532 0.20325732266435792 1.0000000004461073e-14 13.999999999806258 -1.1573049173070737 KQDPEWKPK(ub)TAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQDPEWKPKTAK 12 3 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 13754900.0 3517100.0 5723200.0 4514600.0 True False 3405451.5856632073 8008503.606093721 3332090.8249031156 1.0 2.351671549174021 0.9784578465103022 21.699414691261456 -6.649763158310166 2.0096462069191943 1.8772214456462797 0.9842383067814426 0.19324227099869684 0.5769314905588235 0.5089241390470992 3.93953186311634 0.23286422434866622 0.6389201748520889 2.2399423539506174e-07 6.649763158310166 -0.892983138864837 KQDPEWKPK(ub)TAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQDPEWKPKTAK 12 3 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 6639900.0 1907000.0 2443800.0 2289100.0 True False 2612069.434737251 2335824.8354340866 1748461.725494353 1.0 0.8942430106836146 0.6693779660839037 21.316761816828606 -6.9588301261056955 0.4516184587445942 1.0071326672964602 0.547549835608672 0.999724319618506 0.002289044427799866 0.08012168465066415 0.022695551685694256 0.0030128863671548896 0.018595674558808364 1.0994357986574982e-07 6.9588301261056955 -0.45958283168778824 KQDPEWKPK(ub)TAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQDPEWKPKTAK 12 3 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 12544300.0 3517100.0 6844900.0 2182300.0 True False 2924624.483948374 6808025.16509372 2638608.8401848543 1.0 2.327828821258646 0.9022043187652639 21.479819966695732 -6.662124865161186 1.965262507036058 1.8531908812026099 0.90810821800191 0.2447671310258901 0.5650698608992033 0.47939019261862587 3.5614647518145666 0.23211612777889862 0.6266012437350515 2.1770837432264188e-07 6.662124865161186 -0.9450826632006999 KQDPEWKPK(ub)TAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQDPEWKPKTAK 12 3 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 3413620.0 816470.0 1790900.0 806250.0 True False 1056936.510029807 1691234.8406723768 659520.7728236006 1.0 1.6001290755153135 0.6239928004805144 20.011457286237594 -6.740362588603131 1.6854305379138605 1.3569214064170483 0.6233806122213049 0.6065686808336348 0.25214589959796985 0.3171477186302058 1.7691015553809295 0.11834617783915749 0.29028845173499535 1.818182240564363e-07 6.740362588603131 -0.7335407941957434 KQDQK(ub)APDKEAILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQDQKAPDKEAILR 14 3 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 3100650.0 960240.0 1222800.0 917610.0 True False 1258883.9389773884 1040363.0064370682 822664.5195366554 1.0 0.826416935052942 0.6534871834213081 20.263713851284994 -6.971171886700936 0.2284701001895041 1.0716895899980783 0.40328245981868627 0.9999901343510427 0.00044429364245098354 0.07592425401850209 0.007655624218998249 0.004493891479463264 0.017226787512958648 1.0686318483878699e-07 6.971171886700936 -0.668407130179392 KQEESVQK(ub)QEAMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQEESVQKQEAMR 13 2 Q9NVI7-2;H0Y2W2;Q9NVI7-3;Q9NVI7;Q5T9A4;Q5T9A4-2;Q5T9A4-3 Q9NVI7-2 ATAD3A;ATAD3B ATPase family AAA domain-containing protein 3A;ATPase family AAA domain-containing protein 3B 1 2003140.0 772530.0 653380.0 577230.0 True False 1012794.311191163 555898.2508552921 517503.77678114176 1.0 0.5488757635313843 0.5109663147421292 19.949909775688702 -13.999999999999998 0.3508164299287022 6.57583201198456 0.5057852722202993 0.9997562613810285 0.0034680290892094307 20.74179808366114 0.19072788595552947 86.21922723506552 0.011279550524091481 1.0000000000000041e-14 13.999999999999998 -6.070046739764261 KQEESVQK(ub)QEAMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 KQEESVQKQEAMR 13 2 Q9NVI7-2;H0Y2W2;Q9NVI7-3;Q9NVI7;Q5T9A4;Q5T9A4-2;Q5T9A4-3 Q9NVI7-2 ATAD3A;ATAD3B ATPase family AAA domain-containing protein 3A;ATPase family AAA domain-containing protein 3B 1 11407870.0 4982300.0 2334070.0 4091500.0 True False 7558513.354919998 1917536.972327852 3282813.231631842 1.0 0.25369234428615334 0.4343199618076997 22.84967107541165 -10.752980060559839 10.357064889489944 1.0018134192602115 0.3440061530668173 0.9461964002698914 0.07374091606373183 0.003090528486304239 7.371002145673533e-05 0.0714630099319143 0.023799778320742704 1.7661189053310315e-11 10.752980060559839 -0.6578072661933942 KQEESVQK(ub)QEAMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 KQEESVQKQEAMR 13 2 Q9NVI7-2;H0Y2W2;Q9NVI7-3;Q9NVI7;Q5T9A4;Q5T9A4-2;Q5T9A4-3 Q9NVI7-2 ATAD3A;ATAD3B ATPase family AAA domain-containing protein 3A;ATPase family AAA domain-containing protein 3B 1 7007680.0 2032630.0 2486980.0 2488070.0 True False 2784148.240760347 2377097.0002569226 1900439.1094101314 1.0 0.8537968508486247 0.6825926441657877 21.408804598224933 -6.969045229084939 0.2800535770730063 1.0376927780878615 0.4934793820121349 0.9999739458351162 0.0006620823911781419 0.07661375304295294 0.010134344046996603 0.0031613700492602046 0.01571333336102727 1.0738775688087015e-07 6.969045229084939 -0.5442133960757266 KQEESVQK(ub)QEAMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 KQEESVQKQEAMR 13 2 Q9NVI7-2;H0Y2W2;Q9NVI7-3;Q9NVI7;Q5T9A4;Q5T9A4-2;Q5T9A4-3 Q9NVI7-2 ATAD3A;ATAD3B ATPase family AAA domain-containing protein 3A;ATPase family AAA domain-containing protein 3B 1 8425530.0 2990680.0 4075500.0 1359350.0 True False 2486882.9295882196 4053544.4725765907 1643583.800075736 1.0 1.6299699613313845 0.6609011548235132 21.245907163377638 -6.731261244618785 1.718808908783074 1.3785771928259989 0.6613605457540869 0.5650688096877995 0.26479783308452215 0.33385698082955434 1.9328851080217915 0.12206218538080568 0.30243698110098294 1.85668725123467e-07 6.731261244618785 -0.717216647071912 KQEESVQK(ub)QEAMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 KQEESVQKQEAMR 13 2 Q9NVI7-2;H0Y2W2;Q9NVI7-3;Q9NVI7;Q5T9A4;Q5T9A4-2;Q5T9A4-3 Q9NVI7-2 ATAD3A;ATAD3B ATPase family AAA domain-containing protein 3A;ATPase family AAA domain-containing protein 3B 1 10813330.0 4982300.0 2613430.0 3217600.0 True False 6449685.565815648 2467990.323110398 2632029.8153639873 1.0 0.3826528127496845 0.40808653204958717 22.6207973975041 -10.424148187838183 5.978180992394808 1.0002182446313628 0.39536967239964466 0.9986746660466542 0.010383272424323822 3.021353223517923e-05 2.9103438958462706e-06 0.01005709766687553 0.0033511867648782882 3.7657528388366355e-11 10.424148187838183 -0.6048485722317181 KQELEEICHDLEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQELEEICHDLEAR 14 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 6900700.0 2736700.0 1316100.0 2847900.0 False True 2649824.956493846 1841625.59337083 2101949.554831339 1.0 0.6949989616701335 0.7932409081136301 21.337465629853178 -10.611008953167161 9.361715518441816 1.0000584000115333 0.7441199348918819 0.9004498715672111 0.04010710668739988 4.889791233607568e-05 2.0317517662613142e-06 0.03884234069369958 0.012944513022071984 2.449012753875195e-11 10.611008953167161 -0.25593846511965146 KQELLEALTK(ub)HFQD ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQELLEALTKHFQD 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 9701600.0 4470700.0 2791400.0 2439500.0 True False 5861130.994320382 2374934.000791976 2187083.941336374 1.0 0.40520063501282616 0.37315049662867555 22.48274765077348 -13.76623900050252 0.41801015658537705 9.999999999652731 0.3720063895729652 0.9998583252001405 0.0034308659323489207 24.106720976873017 0.2150577516065261 196.63867265481332 0.007819330105503163 1.7130143437358863e-14 13.76623900050252 -9.627993610079766 KQELLEALTK(ub)HFQD ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQELLEALTKHFQD 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 20995700.0 7284300.0 5811400.0 7900000.0 True False 7053063.883724221 8131922.326050654 5830753.0050801 1.0 1.152963089532767 0.8266978863661298 22.749818676428117 -6.779210580295637 1.538814079541795 1.0867016096003088 0.8241716987266958 0.7646071015415803 0.0646655411012668 0.25181625459866674 1.1777114001071751 0.03309896664478054 0.07815567560709012 1.6626062919340988e-07 6.779210580295637 -0.262529910873613 KQELLEALTK(ub)HFQD ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQELLEALTKHFQD 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 42208600.0 6445600.0 12160000.0 23603000.0 True False 9778446.436479624 9989952.993486362 18937856.704437617 1.0 1.0216298732503855 1.9366938119932584 23.221173842638358 -6.911990060566364 0.882080831187901 0.973418539251276 2.060122582742522 0.9916507176938361 0.039889753353282376 0.10311734589967646 0.13174159548429087 0.03298283254812732 0.09235231671928186 1.2246442266318175e-07 6.911990060566364 1.086704043491246 KQELLEALTK(ub)HFQD ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQELLEALTKHFQD 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 14897200.0 4470700.0 4383300.0 6043200.0 True False 6123638.606124714 4189631.312365264 4615920.623610787 1.0 0.6841735088963116 0.7537872367245931 22.54595771229637 -10.12279265417653 5.208268759955924 1.000007585859932 0.7189803728101645 0.9560016491929146 0.028419685379720935 2.5033960434439132e-06 4.2165289800778407e-07 0.027517984406286458 0.009172414014864313 7.537153252107574e-11 10.12279265417653 -0.2810272130497675 KQELLEALTK(ub)HFQD ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQELLEALTKHFQD 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 18026400.0 7284300.0 4893500.0 5848600.0 True False 6057218.199205342 4867137.744216303 7071515.219128958 1.0 0.8035268970259042 1.1674526138181194 22.530223951862393 -6.760081294411248 1.612225548722674 0.8858888641802762 1.1687847682243948 0.6912806338659319 0.08263781860604215 0.28277864456142054 1.44868010991997 0.0404423101546181 0.09717906523031482 1.7374755649487787e-07 6.760081294411248 0.2828959040441186 KQELLEALTK(ub)HFQD ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQELLEALTKHFQD 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 62856300.0 6445600.0 9705700.0 46705000.0 True False 8343956.261770954 9165569.263004005 38205169.23376905 1.0 1.0984680378775942 4.578783497321478 22.992300164730807 -6.912955430512894 0.87537457576446 0.9020523204538528 5.0581800098581935 0.99198974911462 0.14895764419600166 0.10249574257976989 0.12840890828724072 0.12376456183351274 0.34906060980560777 1.2219250538338847e-07 6.912955430512894 4.15612768940434 up KQFSSASSQQGQEEK(ub)EEDLKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQFSSASSQQGQEEKEEDLKK 21 3 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 4393800.0 1357200.0 1092400.0 1944200.0 True False 1314116.4288937214 1528601.0167907432 1434955.6952502173 1.0 1.1632158180060073 1.0919547642047391 20.325661671427607 -10.111025507910972 4.955718504475145 0.9999949847546344 1.1275852911058928 0.8103909274644616 0.029092203392820377 1.6120878168244073e-06 2.8918342367281826e-07 0.028169512040406207 0.009389468270148957 7.744163117941069e-11 10.111025507910972 0.12759030635125834 KQFSSASSQQGQEEK(ub)EEDLKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQFSSASSQQGQEEKEEDLKK 21 3 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 4012100.0 1357200.0 1358500.0 1296400.0 True False 1128571.9341544842 1351181.490858862 1567471.2461236506 1.0 1.1972488859304788 1.3888979503091983 20.106066946861883 -6.9714781393586644 0.22004712503107882 0.9116724991915464 1.6798861981556457 0.9999917267597933 0.0004566444086072078 0.07582599540488012 0.007289890185476425 0.005306615583869897 0.019422649722596757 1.0678785439066299e-07 6.9714781393586644 0.7682136989640993 KQGDGGK(ub)DLPTEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQGDGGKDLPTEAK 14 2 H3BMM5;A0A2R8YF87;Q96AX1;F5H2X5 H3BMM5 VPS33A Vacuolar protein sorting-associated protein 33A 1 2568290.0 1421700.0 310260.0 836330.0 True False 1840418.675896697 292993.75825954106 684126.5214704643 1.0 0.1591995137284658 0.37172330971763323 20.811602570894728 -10.33099230238557 5.17619232049594 1.000252989274242 0.2654614117823969 0.9409251997029406 0.08676247639572626 0.0002533913787515927 3.2750025931346015e-05 0.08403556408422838 0.028002468846326404 4.66667651650823e-11 10.33099230238557 -0.7347915774918451 KQGGLGPMNIPLVSDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQGGLGPMNIPLVSDPK 17 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 34121200.0 2197200.0 18908000.0 13016000.0 False True 2880550.477715068 16087000.10280674 11669229.178288275 1.0 5.584696476337187 4.051041378571719 21.45791310862409 -9.78612963331583 6.8916118300693014 0.9999999835450126 4.817868927454665 0.8920408664150206 0.6261120718247054 1.5877251073734886e-07 2.6216035509511374e-08 0.6062304067587441 0.2020768022529288 1.636328018126033e-10 9.78612963331583 3.8178689439096525 KQGGLGPMNIPLVSDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQGGLGPMNIPLVSDPK 17 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 41774000.0 13563000.0 4620000.0 23591000.0 False True 13132449.989010844 6464790.092981721 17411809.385170206 1.0 0.492276010827486 1.325861465281825 23.646632754644127 -6.74186989784087 1.6799973525598497 0.6985557302863632 1.3265363638519863 0.6132177859764881 0.21331723359995095 0.31445749602018647 1.7433812447334882 0.10042369057919111 0.24591267900191263 1.8118827993973493e-07 6.74186989784087 0.6279806335656231 KQGGLGPMNIPLVSDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQGGLGPMNIPLVSDPK 17 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 32373200.0 2197200.0 13343000.0 16833000.0 False True 3009564.217097374 12753462.140599497 12857392.08651715 1.0 4.237644130717301 4.2721773516159365 21.521123170146982 -10.413532988956119 0.8759646964631228 3.147479140790414e-16 4.263964224409071 0.9999835889978475 0.006216107576548472 1.8332857587166764 0.4837604686230283 4.3507482512167615 0.004772472820400125 3.8589309808853755e-11 10.413532988956119 4.263964224409071 KQHLEIELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQHLEIELK 9 1 P15924;P15924-3 P15924 DSP Desmoplakin 0 12766100.0 4182800.0 5197500.0 3385800.0 False True 6345613.403640763 4269965.516747148 2716595.145951144 1.0 0.672900355747685 0.4281059959298043 22.597328199366412 -7.669079500387517 0.17265654307531536 1.2657653649427802 1.9254037186483406e-10 0.9999562444809356 0.00154969904486027 0.13394084057570624 0.020310716659555125 0.05046918259530005 0.08214166971373583 2.142498367167193e-08 7.669079500387517 -1.2657653647502398 down KQHLEIELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQHLEIELK 9 1 P15924;P15924-3 P15924 DSP Desmoplakin 0 7044900.0 3228900.0 1688000.0 2128000.0 False True 4422711.587741541 1613418.5785304601 1625410.2275357028 1.0 0.3648030278534063 0.3675144072339836 22.076499734124226 -10.270076302451182 8.433094112319237 1.0000004430627976 0.36615871754371115 0.9999862758121884 0.001106915996919653 9.219955062234022e-09 7.99183530432261e-10 0.001071767555967194 0.0003572556018100331 5.3693745199178624e-11 10.270076302451182 -0.6338417255190865 KQHLEIELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQHLEIELK 9 1 P15924;P15924-3 P15924 DSP Desmoplakin 0 13241500.0 4182800.0 7397800.0 1660900.0 False True 5414717.055314554 6986105.926811167 1358633.2422731398 1.0 1.290207014594473 0.25091490993784044 22.36845452145886 -6.83218015414856 1.318132230712073 1.1548481640750794 0.2216804211835094 0.9101668902420675 0.13123555332718873 0.17813585385595707 0.6045376880631591 0.07815356396874125 0.17985163272208926 1.4717018840393962e-07 6.83218015414856 -0.93316774289157 down KQIFILLFQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQIFILLFQR 10 1 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 1338630.0 401250.0 537290.0 400090.0 False True 526042.635710527 457128.42634001595 358692.52473427745 1.0 0.8689950116354572 0.6818696820074112 19.004820209002624 -6.966057545851157 0.3394137730105202 1.0204347506463538 0.5242167838394125 0.9999333116863893 0.0010660776160664835 0.07760390599372072 0.013604669654072362 0.0026462924252077494 0.01620346910270751 1.0812906662299272e-07 6.966057545851157 -0.4962179668069413 KQININNPFVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQININNPFVFK 12 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 3299890.0 1125400.0 702390.0 1472100.0 False True 1541490.7927914567 671356.0873068788 1124420.2988511794 1.0 0.43552390351364517 0.7294369217833523 20.555894841686047 -10.024899051840762 5.137382830915953 1.0000040851686 0.5824804126465737 0.7290439234621251 0.11998948726042614 5.6142843056494124e-06 1.0658956801054584e-06 0.11618045686465164 0.03872644048899754 9.442803409314296e-11 10.024899051840762 -0.4175236725220264 KQLAEEETK(ub)ITDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQLAEEETKITDK 13 2 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 14916500.0 6239000.0 5523000.0 3154500.0 True False 8179389.418561935 4698989.928485385 2828102.6001006705 1.0 0.5744915284045177 0.345759622800536 22.96356172108651 -9.77857403552898 0.15072383961388786 1.6539267212850037 1.9014344830181536e-10 0.9997563748312542 0.004231297421994995 1.2680949158580164 0.0650894663596071 0.5315396490273386 0.1919547938967666 1.6650449582050233e-10 9.77857403552898 -1.6539267210948603 KQLAEEETK(ub)ITDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQLAEEETKITDK 13 2 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 19666600.0 5021600.0 7370400.0 7274600.0 True False 4862192.056684866 10313439.156128235 5369164.026677924 1.0 2.1211500977113054 1.1042681909892966 22.21317545029971 -6.622812185818328 2.1059946142377584 1.7424193452596943 1.1081734183963339 0.09247413176794539 0.481782820032046 0.5779001802737592 4.874151477758613 0.1877004315166354 0.5341979177548349 2.3833499455961672e-07 6.622812185818328 -0.6342459268633605 KQLAEEETK(ub)ITDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQLAEEETKITDK 13 2 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 28356600.0 12818000.0 10447000.0 5091600.0 True False 19445843.121322416 8582651.227216454 4085243.028272442 1.0 0.4413617436728961 0.21008310119466936 24.212958451854888 -10.585920842669468 0.1886710080891775 1.834670351575779 1.5888662193370744e-21 0.999453347342718 0.007752646552122086 2.3864448566175103 0.09848554297572261 1.0699547237028295 0.15236756955775924 2.594652237177049e-11 10.585920842669468 -1.834670351575779 KQLAEEETK(ub)ITDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQLAEEETKITDK 13 2 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 17761200.0 5021600.0 10594000.0 2145600.0 True False 4175682.894599283 10536928.019255646 2594235.039866479 1.0 2.5234023476456575 0.621272042286016 21.993580725733985 -6.693441932879556 1.8541817897580117 1.9519727233380182 0.6275569840885348 0.38660299341418025 0.6438476386183446 0.40930195545907727 2.7308614544609826 0.2775154941109512 0.7195510692476688 2.0256204232572592e-07 6.693441932879556 -1.3244157392494835 KQMVIDVLHPGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQMVIDVLHPGK 12 1 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4 E7ETK0 RPS24 40S ribosomal protein S24 0 48078000.0 12270000.0 15629000.0 20179000.0 False True 16086088.82284902 13297214.121364849 18091070.650636062 1.0 0.8266281672196913 1.1246407283875695 23.939310255543226 -6.7489717646374245 1.6534622266543502 0.8979322421402969 1.1251941442683224 0.6446371598750944 0.0728486991432637 0.30182917305917073 1.623194136384846 0.03480767193768938 0.08460127785307732 1.7824946513674975e-07 6.7489717646374245 0.22726190212802555 KQMVIDVLHPGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQMVIDVLHPGK 12 1 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4 E7ETK0 RPS24 40S ribosomal protein S24 0 28377800.0 9128100.0 5526700.0 13723000.0 False True 8838333.461969316 7733540.131359764 10128534.618824579 1.0 0.8749998135549655 1.1459778772103248 23.075342932966493 -6.781290331428561 1.5309889117962194 0.9293400284638674 1.14820630030401 0.7718786487066289 0.052890154242399644 0.24857658098075128 1.1509373946882613 0.027208002316114442 0.06412664003972716 1.654663429930055e-07 6.781290331428561 0.2188662718401425 KQMVIDVLHPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQMVIDVLHPGK 12 1 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4 E7ETK0 RPS24 40S ribosomal protein S24 0 40509000.0 12270000.0 13719000.0 14520000.0 False True 16806550.584282164 13112849.217333756 11090675.048786858 1.0 0.7802225180934609 0.6599019229537255 24.002520317066118 -13.99999999999215 0.07287255807654958 2.2436536407250074 0.24791747471349282 0.9999143418888228 0.001303202799945562 12.33061042069436 0.07381579080069675 2.5633279070615225 0.3778037171106422 1.0000000000180747e-14 13.99999999999215 -1.9957361660115145 KQMVIDVLHPGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQMVIDVLHPGK 12 1 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4 E7ETK0 RPS24 40S ribosomal protein S24 0 18775900.0 9128100.0 5706200.0 3941600.0 False True 7590419.593394876 5675459.568007986 4765770.336100733 1.0 0.7477135483981315 0.6278665200864348 22.85574820840077 -13.999999999999352 0.09885839339272431 2.2502113226432128 0.36802664164329046 0.9997994223452428 0.0021965573474360504 12.08924891320843 0.09340308921192286 3.092583882625791 0.23189989124110916 1.000000000001493e-14 13.999999999999352 -1.8821846809999223 KQMVIDVLHPGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQMVIDVLHPGK 12 1 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4 E7ETK0 RPS24 40S ribosomal protein S24 0 35028000.0 10256000.0 14314000.0 10458000.0 False True 13276594.17598404 13517413.316982733 8554751.308141649 1.0 1.0181386233401868 0.6443483317141901 23.662381766047073 -6.89549527834743 0.9892871013882747 1.0175192557464001 0.6085100263335129 0.984189398607043 0.021638697114767045 0.11479830094195637 0.19669951581080578 0.01653357175994599 0.04212409656148905 1.2720515797639655e-07 6.89549527834743 -0.4090092294128872 KQNNFSLAMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQNNFSLAMK 10 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 9849500.0 3651900.0 3116400.0 3081200.0 False True 4787676.2650499055 2651445.267632058 2762386.980957422 1.0 0.5538062978459175 0.5769786485195083 22.190894172190944 -10.330140031526568 5.715613429821502 1.0000644817197206 0.5653924731827137 0.997872438366653 0.00946007254853111 7.77426564746427e-06 9.111308472043107e-07 0.009161028051730044 0.003053225286196673 4.675843516493514e-11 10.330140031526568 -0.43467200853700694 KQNNFSLAMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQNNFSLAMK 10 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 6560900.0 3651900.0 1341300.0 1567700.0 False True 5002106.1188867185 1282036.930914045 1197441.547794981 1.0 0.2562994267701339 0.23938747386300685 22.254104233713836 KQNNFSLAMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQNNFSLAMK 10 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 2578450.0 919730.0 964630.0 694090.0 False True 764796.2459474674 959433.3467259369 839221.0098904386 1.0 1.254495366327725 1.0973131920264203 19.544715916209626 -10.207473478899782 4.158228700771191 0.9999109595490242 1.1759042791816727 0.6254511659697284 0.0641693539974641 45142719.20350427 6.229458182218636 38501.89592573867 0.02196687667112435 6.201925158495908e-11 10.207473478899782 0.17599331963264853 KQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGK 40 2 Q12906-7;Q12906 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 20111400.0 2835000.0 6804300.0 10472100.0 False True 3716712.4541790495 5789124.962953671 9388547.547476385 1.0 1.5575929088741889 2.5260354851825992 21.82559564682255 -6.962707233993352 0.3954337888528328 0.9440068740216433 3.1747235843800192 0.9998578043747023 0.007518238856135691 0.07874784777603379 0.017659118422938293 0.012473710060809756 0.08128218911497957 1.08966440888998e-07 6.962707233993352 2.230716710358376 KQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGK 40 2 Q12906-7;Q12906 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 18544600.0 1447700.0 5139900.0 11957000.0 False True 1401743.555930915 7192288.874224406 8825102.997688938 1.0 5.1309591143066955 6.295804222069763 20.418791006813166 -9.294488719235263 0.42214376102887236 9.303067704836622e-21 6.42445747703368 0.9979223635286552 0.10357070093099137 0.6705594993543527 0.16834053753294856 1.4022582305378635 0.2770257747760196 5.075879234137391e-10 9.294488719235263 6.42445747703368 KQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGK 40 2 Q12906-7;Q12906 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 27696400.0 2835000.0 9226600.0 15634800.0 False True 3883176.112994286 8818938.303713962 11942182.24881355 1.0 2.271063183099813 3.0753645730492067 21.88880570834544 -8.46272029247829 0.19214208304458957 2.3124543005016366e-26 4.089743590048997 0.9997475281473862 0.013575504885611581 0.14429307418341528 0.04845771088698944 0.4627897151401817 0.40252215988335627 3.445717808972795e-09 8.46272029247829 4.089743590048997 KQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGK 40 2 Q12906-7;Q12906 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 17823400.0 1447700.0 9090400.0 7285300.0 False True 1203826.693984265 9041428.210896876 8808622.546578702 1.0 7.5105729554582 7.317184932513083 20.199196282247442 -9.78659758536915 6.089770644834002 0.9999997383303656 7.413878943995327 0.9993186302016368 0.07895032979805088 2.8074066388483077e-07 5.536694077278007e-08 0.07644333266147695 0.025481109368723484 1.634565825183393e-10 9.78659758536915 6.413879205664961 KQPPVSPGTALVGSQK(ub)EPSEVPTPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQPPVSPGTALVGSQKEPSEVPTPK 25 2 P17096;P17096-3 P17096 HMGA1 High mobility group protein HMG-I/HMG-Y 1 18288200.0 8386100.0 5902000.0 4000100.0 True False 8119887.845819065 8258699.378523401 2952353.809572262 1.0 1.0170952524640855 0.3635953926497188 22.953028369961462 -6.9008962205424185 0.9556161134037763 1.0265060518732498 0.29374499397951265 0.9870060398592989 0.03466621656527754 0.1107475864177124 0.1737361142489162 0.027161735315419426 0.07099082889901757 1.2563301417752084e-07 6.9008962205424185 -0.7327610578937371 down KQPPVSPGTALVGSQK(ub)EPSEVPTPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQPPVSPGTALVGSQKEPSEVPTPK 25 2 P17096;P17096-3 P17096 HMGA1 High mobility group protein HMG-I/HMG-Y 1 14356600.0 8386100.0 4443000.0 1527500.0 True False 6973413.717221425 4419064.677133547 1846893.1876379775 1.0 0.6337017788318366 0.26484778654060365 22.73343364539574 -7.484471950673416 0.31527889073434 1.0770322469909075 1.3667367570502386e-11 0.9996473345722324 0.005636165467285737 0.1220922919150943 0.03264235726999393 0.021070085665356626 0.06404859421249023 3.277389434563363e-08 7.484471950673416 -1.0770322469772402 down KQQAK(ub)FDECVLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQQAKFDECVLDK 13 2 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 356966390.0 101518390.0 171638700.0 83809300.0 True False 133091592.39548735 146030875.0024124 75137517.59157307 1.0 1.0972208865641597 0.5645549522639922 26.98784419592007 -6.8596248808851605 1.187584861967024 1.0526990868606063 0.5389398031516262 0.95318354951218 0.05011415306945944 0.14719406688961528 0.39467871816389893 0.032916777891337984 0.07680771247780685 1.3815770778583644e-07 6.8596248808851605 -0.5137592837089802 KQQAK(ub)FDECVLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQQAKFDECVLDK 13 2 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 138226000.0 72466000.0 38240000.0 27520000.0 True False 70165606.49588287 53509431.41896561 20311686.41769672 1.0 0.7626162459253509 0.28948209004490766 26.064260693360332 -6.960112131687625 0.4338499038247742 1.0180439536112986 0.015794631110971794 0.9997743370143425 0.004436650066600372 0.07966107937731635 0.0209834239017302 0.006193719533681212 0.0392509496443549 1.0961951299641915e-07 6.960112131687625 -1.0022493225003268 down KQQAK(ub)FDECVLDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQQAKFDECVLDK 13 2 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 1486520900.0 354440000.0 405310900.0 726770000.0 True False 537711393.0349131 332980003.1864844 583123590.9453926 1.0 0.619254134280291 1.084454594971788 29.002256798874523 -6.689130845967863 1.8692508275556765 0.7611083029655125 1.0828421641630432 0.36649970485476435 0.1610562770917946 0.4185253661994641 2.834530702615631 0.06894113438304109 0.17974122468541368 2.0458281686203832e-07 6.689130845967863 0.3217338611975308 KQQAK(ub)FDECVLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQQAKFDECVLDK 13 2 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 324399390.0 101518390.0 92478000.0 130403000.0 True False 139052482.21433467 88392016.17614938 99604497.13408762 1.0 0.6356737741646529 0.7163086594927363 27.05105425744296 -9.964373498410524 5.664260396390992 1.0000004410609458 0.6759912168284175 0.9556110552062146 0.03291905408792766 1.833215663804082e-07 3.3540617795156635e-08 0.03187378028335099 0.010624579021143296 1.0854916863384896e-10 9.964373498410524 -0.3240092242325283 KQQAK(ub)FDECVLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQQAKFDECVLDK 13 2 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 137589000.0 72466000.0 21239000.0 43884000.0 True False 60258689.78812164 21124581.29138858 53059941.50330935 1.0 0.35056489554727616 0.8805359308321481 25.844665968794608 -10.185337118201131 7.628836040746804 1.000000234374223 0.6155504131897728 0.4123310327755999 0.2163597691504126 8.624451380916964e-07 9.206764367670729e-08 0.2094895736607442 0.06982981522573577 6.526237611251097e-11 10.185337118201131 -0.38444982118445015 KQQAK(ub)FDECVLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQQAKFDECVLDK 13 2 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 1269540000.0 354440000.0 403430000.0 511670000.0 True False 458829567.0569217 380978765.8565287 418551310.1775529 1.0 0.8303274095875016 0.9122152106767523 28.773383120966972 -10.093551995161324 4.521435389118931 1.0000100589156131 0.8712713101497882 0.767169312999039 0.03343055482271623 46511397.75249018 1.0556965197868735 4969.133439802755 0.01144416811373329 8.062096735073291e-11 10.093551995161324 -0.12873874876582492 KQQISLATQMVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQQISLATQMVR 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 38977400.0 11014600.0 12798900.0 15163900.0 False True 14440247.265538141 10889354.009721445 13594885.090399917 1.0 0.7540974755819484 0.9414579155333653 23.783592110433258 -9.821382410761503 5.1998608222092395 1.0000001131959626 0.847777695753859 0.4681176992630499 0.07648957933173524 103549182.7730072 16.857455485351974 140.29622784787773 0.026184417505587195 1.5087510635144674e-10 9.821382410761503 -0.15222241744210363 KQQISLATQMVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQQISLATQMVR 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 12095800.0 3842300.0 1382200.0 6871300.0 False True 3720328.2896686834 1934119.6680777771 5071500.395418593 1.0 0.5198787627018855 1.3631862568424677 21.82699850274879 -6.752264580741593 1.641361152083695 0.7184543404200532 1.3651662300329817 0.6586891719849367 0.20177745542288153 0.2961169858735187 1.5702404174956452 0.09708195087658128 0.23514059657096237 1.7690309015393835e-07 6.752264580741593 0.6467118896129285 KQQISLATQMVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQQISLATQMVR 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 34291900.0 8033500.0 18930400.0 7328000.0 False True 12187406.827519404 15552122.216109732 5879617.5880235 1.0 1.2760813219915441 0.4824338492374939 23.53888785374131 -6.812713437531402 1.4028496844743297 1.1499845885360884 0.46763486770093265 0.8668740968794859 0.12002818754092104 0.20310708323446855 0.7872284900065935 0.06726343946225559 0.15542988951702486 1.539169902668161e-07 6.812713437531402 -0.6823497208351558 down KQQISLATQMVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQQISLATQMVR 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 25657600.0 11014600.0 7690100.0 6952900.0 False True 15086995.278372817 7350325.954239999 5310768.219470392 1.0 0.48719614599314415 0.3520096693530069 23.84680217195615 -13.999999999999998 0.18715433641362023 3.7224572883081604 0.2521989525700346 0.9994912278580609 0.006295655249246258 12.305738553376978 0.13718432382404452 12.206147811588524 0.09511727409749691 1.0000000000000041e-14 13.999999999999998 -3.4702583357381256 KQQISLATQMVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQQISLATQMVR 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 9168600.0 3842300.0 3428700.0 1897600.0 False True 3195042.6927510807 3410228.9125563353 2294379.3864889215 1.0 1.0673500295609413 0.7181060183309644 21.607403778183066 -6.856719478018295 1.202175744589895 1.0362693429849756 0.7022216372966424 0.9495276361076789 0.0339867202999644 0.15022187309495882 0.41441815142316224 0.022077194395769967 0.0513599245468342 1.3908507274064603e-07 6.856719478018295 -0.3340477056883332 KQQISLATQMVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQQISLATQMVR 12 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 38735700.0 8033500.0 19553200.0 11149000.0 False True 10399524.11395944 18465047.231355783 9119996.398400394 1.0 1.77556655756679 0.8769628589214467 23.31001417583376 -6.678399264518353 1.9077346113509805 1.4914254297588347 0.8804408035327316 0.31669747105657375 0.32882142873602493 0.4421162685796222 3.109602151484078 0.13838084537350948 0.365698976644761 2.0970111298490237e-07 6.678399264518353 -0.6109846262261032 KQQLEVELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQQLEVELR 9 1 P15924 P15924 DSP Desmoplakin 0 6257200.0 2376400.0 1648300.0 2232500.0 False True 3115483.4130903394 1402380.0650230763 2001502.3156521618 1.0 0.45013241255937686 0.6424371599099008 21.57102460530476 -10.675216541220468 10.626555039747807 1.0001604922410272 0.5462847862346388 0.881264431763014 0.0785080843539365 0.0002986139249971826 9.126600789574035e-06 0.0760408416012408 0.025338375270453593 2.112435507178289e-11 10.675216541220468 -0.4538757060063884 KQQLEVELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQQLEVELR 9 1 P15924 P15924 DSP Desmoplakin 0 5231200.0 2376400.0 1278600.0 1576200.0 False True 3255019.2997952877 1222107.2242352169 1203934.0228579766 1.0 0.37545314226311244 0.36987001058140995 21.634234666827652 KQSLGELIGTLNAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQSLGELIGTLNAAK 15 1 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 22264500.0 3471900.0 12839000.0 5953600.0 False True 4551694.52192743 10923471.246030018 5337578.582963813 1.0 2.3998691461843613 1.172657470146656 22.117972306562514 -6.614391910114914 2.1375080028866655 1.9324840424318812 1.1771947015963335 0.06424314784494978 0.6028572034918032 0.6006299165589574 5.206561058601418 0.23239028181695828 0.6688502735964595 2.4300101626575386e-07 6.614391910114914 -0.7552893408355477 KQSLGELIGTLNAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQSLGELIGTLNAAK 15 1 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 13658700.0 6078700.0 2526000.0 5054000.0 False True 5885734.995812158 3534644.9729159824 3730205.7832499715 1.0 0.6005443628418485 0.633770597198838 22.488791155973118 -9.906698150098057 5.630605994243673 1.000000267342663 0.6171574805909177 0.9943825816826838 0.013564553377663944 4.55161365032653e-08 8.863329341923719e-09 0.013133831333819533 0.004377940777118587 1.239657892905012e-10 9.906698150098057 -0.3828427867517452 KQSLGELIGTLNAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQSLGELIGTLNAAK 15 1 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 19081800.0 3471900.0 7717400.0 7892500.0 False True 4755555.254569625 7376419.749970968 6028454.051139821 1.0 1.55111640073637 1.2676656517337412 22.181182368085405 -10.12024890770566 4.653511970983077 0.9999680819656817 1.4093910262395706 0.7355462048019645 0.11571828373536287 3.95934628971475e-05 7.484973890856956e-06 0.11205275679668583 0.03734791547644226 7.581429351388436e-11 10.12024890770566 0.4094229442738889 KQSLGELIGTLNAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQSLGELIGTLNAAK 15 1 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 14842900.0 2629700.0 7114300.0 5098900.0 False True 3404198.4891366297 6718382.951027694 4170952.5191321024 1.0 1.9735579380776958 1.2252377563888575 21.698883728247147 -10.201684621909804 4.686208977355855 0.9998937790340662 1.5993978472340267 0.46104692633062794 0.305500434909493 0.00034733936043569475 5.917167217429348e-05 0.29585279688915606 0.09859984138641754 6.285146109446394e-11 10.201684621909804 0.5995040681999605 KQTIDNSQGAYQEAFDISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQTIDNSQGAYQEAFDISK 19 1 P27348 P27348 YWHAQ 14-3-3 protein theta 0 13335450.0 3265400.0 863450.0 9206600.0 False True 3161741.664389594 1208230.0878322655 6795115.267920299 1.0 0.3821406731107889 2.149168398055116 21.592288063924432 -6.812261148071618 1.4052183367472768 0.6641677108889202 2.1816426997974507 0.8655976013764685 0.26842226904405625 0.20373570025705323 0.7925003330148058 0.15018743486770642 0.347037712973271 1.5407736829977136e-07 6.812261148071618 1.5174749889085306 up KQTK(ub)NDPFTSDPFTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQTKNDPFTSDPFTK 15 2 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 17693300.0 4237100.0 4807500.0 8648700.0 True False 4102595.5797712817 6727159.820781304 6383346.01456155 1.0 1.6397326253533233 1.555928653079039 21.96810551448443 -10.568692157370803 6.152445852609679 0.9986726701736025 1.5978306392160877 0.9854761991159855 0.034212828415057586 0.0006240618582682243 4.3748797560602395e-05 0.03318819412833892 0.011042142889847492 2.6996523593639376e-11 10.568692157370803 0.5991579690424852 KQTK(ub)NDPFTSDPFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQTKNDPFTSDPFTK 15 2 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 33808000.0 9903000.0 14909000.0 8996000.0 True False 12819628.717313772 14079301.043935714 7358820.306754871 1.0 1.098261217574942 0.5740275688964602 23.611851143372025 -6.858242151371672 1.1945322733847572 1.0530870090465774 0.5494751725821622 0.9514671795688101 0.05012521378907829 0.14863164033323886 0.403994873786675 0.03274986446066217 0.07630570335137069 1.385982825208525e-07 6.858242151371672 -0.5036118364644152 KQTTLAFKPIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQTTLAFKPIK 11 2 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 0 2348200.0 677820.0 895130.0 775250.0 False True 928428.3713967513 855580.1968009308 592151.9167749311 1.0 0.9215360313836318 0.6378003247402734 19.824431084417775 -6.9471953939367825 0.5888382821508087 1.0032910754094047 0.5417967685767028 0.9989623348644089 0.005011722300785662 0.08463205925693676 0.040778049635987856 0.005202074871596023 0.02376171707929341 1.1292877212049061e-07 6.9471953939367825 -0.4614943068327019 KQVSSHIQVLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KQVSSHIQVLAR 12 1 A0A0A0MRF3;H0YEJ9;P28347-2;Q15561-3;Q15561;P28347;Q99594;A0A1X7SBS4;Q53GI4;H0YE88;H0YGS2;Q15562-2;H0YG62;Q15562;Q15562-4 A0A0A0MRF3 TEAD4;TEAD1;TEAD3;TEAD2 Transcriptional enhancer factor TEF-1;Transcriptional enhancer factor TEF-3;Transcriptional enhancer factor TEF-5;Transcriptional enhancer factor TEF-4 0 4245600.0 1400900.0 1286500.0 1558200.0 False True 2125267.7195085455 1056914.0235296204 1250221.0870166793 1.0 0.4973086514361706 0.5882652220896598 21.019213158000007 -10.36573404407341 6.9216291341306535 1.000018619331624 0.5427869367629737 0.9711736884266091 0.037132864475742544 1.0669676394016562e-05 9.777138241041602e-07 0.03595520248232129 0.011984580475960665 4.307903397698632e-11 10.36573404407341 -0.4572316825686503 KQVSSHIQVLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQVSSHIQVLAR 12 1 A0A0A0MRF3;H0YEJ9;P28347-2;Q15561-3;Q15561;P28347;Q99594;A0A1X7SBS4;Q53GI4;H0YE88;H0YGS2;Q15562-2;H0YG62;Q15562;Q15562-4 A0A0A0MRF3 TEAD4;TEAD1;TEAD3;TEAD2 Transcriptional enhancer factor TEF-1;Transcriptional enhancer factor TEF-3;Transcriptional enhancer factor TEF-5;Transcriptional enhancer factor TEF-4 0 1803680.0 462560.0 684470.0 656650.0 False True 633580.9322139819 654227.8521603942 501562.7941312595 1.0 1.0325876599130972 0.7916317689337669 19.273169392218175 -6.872777074782113 1.1193617228467345 1.0187773898278965 0.7767587791591768 0.967374070031342 0.019279898822633458 0.13421692184233475 0.3126303901425245 0.013343881431864905 0.03175218051423359 1.3403645257282455e-07 6.872777074782113 -0.24201861066871966 KQVVNIPSFIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQVVNIPSFIVR 12 1 P46781 P46781 RPS9 40S ribosomal protein S9 0 16303400.0 3801900.0 11066000.0 1435500.0 False True 4984327.7176519735 9414995.934930157 1286968.2302883235 1.0 1.8889199242632047 0.25820297203382747 22.248967497454924 -6.758652668344011 1.617305866654848 1.517183602608687 0.2525866951204705 0.6855646499145625 0.37381524582276554 0.28517135998248533 1.469779817954779 0.18238592471188517 0.4389284654233051 1.7432004592577754e-07 6.758652668344011 -1.2645969074882164 KQVVNIPSFIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQVVNIPSFIVR 12 1 P46781 P46781 RPS9 40S ribosomal protein S9 0 42100500.0 17574900.0 6634400.0 17891200.0 False True 17016994.41951389 9283550.517938951 13204957.995504947 1.0 0.545545840180404 0.7759865032547952 24.02047291163677 -10.2662490096243 4.834367550683762 1.0000962218293792 0.660766171717179 0.742895834139939 0.0940770067550127 9.75942529127231e-05 1.4812784127993142e-05 0.09111539998404047 0.030363223368382375 5.416902146749179e-11 10.2662490096243 -0.3393300501122002 KQVVNIPSFIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQVVNIPSFIVR 12 1 P46781 P46781 RPS9 40S ribosomal protein S9 0 27135200.0 3801900.0 10039800.0 13293500.0 False True 5207565.172484301 9596208.43882116 10153849.088226445 1.0 1.8427438007930352 1.9498265987869507 22.312177558977815 -11.0452471736063 0.37504500637306987 8.721055658825155e-15 1.9626008302692883 0.9994594202353759 0.00987602334146789 2.9027169499595677 0.1858994637024103 2.5179266228710504 0.029389934354809355 9.01058164966332e-12 11.0452471736063 1.9626008302692797 KQVVNIPSFIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQVVNIPSFIVR 12 1 P46781 P46781 RPS9 40S ribosomal protein S9 0 22862700.0 17574900.0 1843100.0 3444700.0 False True 14614308.050082251 1833170.8544732933 4164970.843506744 1.0 0.12543671915161086 0.28499268177690446 23.800878187071046 -9.889114001497846 6.376022059656307 1.000000065647198 0.2052147004641762 0.9706603465077851 0.06513844897538465 6.082271909502701e-08 1.0465302367665164e-08 0.06307003765857243 0.021023344006577457 1.2908803754256052e-10 9.889114001497846 -0.7947853651830217 KQYPISLVLAPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KQYPISLVLAPTR 13 1 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;A0A2R8YDH3;O15523-3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 22437500.0 6670300.0 8121100.0 7646100.0 False True 8744827.895277096 6909463.53579987 6854954.918570217 1.0 0.7901200136290311 0.7838867729200752 23.059998560438107 KQYPISLVLAPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KQYPISLVLAPTR 13 1 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;A0A2R8YDH3;O15523-3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 18463300.0 7326900.0 4416800.0 6719600.0 False True 7094311.570042298 6180451.273307728 4959535.176321035 1.0 0.8711840764657702 0.6990861801536953 22.758231261689765 -6.96710999116826 0.31977785031924083 1.0236302941654334 0.5410908713300843 0.9999502621773614 0.0008693460056702415 0.07725208150131188 0.012372823838117669 0.0026110176752626047 0.015141096105027145 1.0786734984411858e-07 6.96710999116826 -0.4825394228353491 KQYPISLVLAPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KQYPISLVLAPTR 13 1 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;A0A2R8YDH3;O15523-3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 22733300.0 6670300.0 6627300.0 9435700.0 False True 9136490.168079661 6334483.972449606 7207181.994341458 1.0 0.693317002034383 0.7888348656600468 23.123208621961 -10.470752711745202 8.759286281556458 1.0000059888565003 0.7410759338472149 0.9073857931508927 0.03899500453393767 4.560754596247521e-06 2.755645783321811e-07 0.037757623997482045 0.012585583595435273 3.382573858979939e-11 10.470752711745202 -0.25893005500928534 KQYPISLVLAPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KQYPISLVLAPTR 13 1 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;A0A2R8YDH3;O15523-3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 16036200.0 7326900.0 4153000.0 4556300.0 False True 6092641.986705341 4130626.9646940413 5509001.264049057 1.0 0.6779697500209955 0.9042056428180356 22.53863653712404 -10.027270658457804 5.625779477115257 1.0000007040495924 0.7910876964194204 0.5320447023930095 0.09236041647629309 8.15582584479559e-07 1.4093823292224358e-07 0.0894278898703497 0.02980919623840654 9.391378441733997e-11 10.027270658457804 -0.20891300763017195 KQYPISLVLAPTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KQYPISLVLAPTR 13 1 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;A0A2R8YDH3;O15523-3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 16859900.0 4090900.0 6132900.0 6636100.0 False True 5295750.693694731 5791598.72374763 5428397.892136052 1.0 1.0936313015345056 1.025047855556957 22.336403775790256 -10.406242223750434 4.393307958894493 0.9998538550902544 1.059339578545924 0.49953316716681306 0.027999074575106468 4.017797161594711e-05 5.430109534988115e-06 0.027176704248561636 0.009036662461459507 3.924260023600435e-11 10.406242223750434 0.059485723455669715 KRFDTEEEFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KRFDTEEEFK 10 2 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 5580890.0 614390.0 3175900.0 1790600.0 False True 932074.5479255157 2609135.831580042 1436687.1251521385 1.0 2.79927805923582 1.541386499985136 19.830085821613984 -10.495427496980529 5.172642492902815 0.9971269974361084 2.170332279610495 0.5357846087936287 0.513532078653074 0.017036080196173056 0.0016618055325624682 0.49785757751648907 0.16574176569721094 3.195747832391685e-11 10.495427496980529 1.1732052821743864 KRLEAFLTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KRLEAFLTQK 10 2 Q02750;Q02750-2;P36507 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 0 6668500.0 2229400.0 1321600.0 3117500.0 False True 2922764.9895403087 1124422.4315564525 2794931.005171609 1.0 0.38471188603271905 0.9562626537452793 21.478902400501905 -10.693194510851669 9.793631252015484 1.0003259360293955 0.6704872698890011 0.30708248457033027 0.2333346238319612 0.0016621238114762162 5.2069368021087304e-05 0.2261365363950876 0.07530842601622982 2.026774768811811e-11 10.693194510851669 -0.32983866614039437 KRLEAFLTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KRLEAFLTQK 10 2 Q02750;Q02750-2;P36507 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 0 4640500.0 2229400.0 1133600.0 1277500.0 False True 3053669.4272696525 1083513.8036860966 975780.8109383754 1.0 0.3548235424601569 0.31954369462016086 21.542112462024797 -13.690183792702769 0.4165607274089663 9.999988995339413 0.3182159074698131 0.9998551538593748 0.00376444404037613 22.402940760090427 0.2144256383358388 181.5814581867977 0.00863947626478578 2.0408740673741494e-14 13.690183792702769 -9.6817730878696 KRPLNK(ub)QELAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KRPLNKQELAK 11 3 Q99661;Q99661-2;Q5JR91;Q5JR89 Q99661 KIF2C Kinesin-like protein KIF2C;Kinesin-like protein 1 4089950.0 1728400.0 1451500.0 910050.0 True False 1673532.888078327 2031091.519472503 671680.6040852083 1.0 1.213654977408153 0.4013548875376337 20.674465472306363 -6.836785590782154 1.297142652647408 1.1137509236916725 0.37627750252168213 0.9188027290322355 0.09796949181516493 0.17258496960258354 0.5654492397044278 0.059251211918641904 0.1364154895569882 1.4561778115376022e-07 6.836785590782154 -0.7374734211699904 down KRPLNK(ub)QELAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KRPLNKQELAK 11 3 Q99661;Q99661-2;Q5JR91;Q5JR89 Q99661 KIF2C Kinesin-like protein KIF2C;Kinesin-like protein 1 4324770.0 1728400.0 2120000.0 476370.0 True False 1437241.1811027175 2108579.1392129455 575976.7645139806 1.0 1.4671018107031601 0.4007516428607095 20.45487074774064 -6.78764458281638 1.505742983519967 1.2618662800259337 0.3901372299474132 0.7935929175114201 0.19828746903621677 0.23888453350161096 1.0700092424224557 0.10366811466738277 0.24313416820664602 1.630629958925163e-07 6.78764458281638 -0.8717290500785205 down KSAEFLLHMLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSAEFLLHMLK 11 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 157668000.0 0.0 94420000.0 63248000.0 False True 0.0 89165443.99814938 51737512.97928323 0.0 KSAEFLLHMLK(ub)NAESNAELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSAEFLLHMLKNAESNAELK 20 2 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 48529000.0 10945000.0 15999000.0 21585000.0 True False 14168518.25820452 15108641.585748691 17656751.480803013 1.0 1.066352974278011 1.246196049511287 23.756185553496643 -6.95370780859709 0.5165365597951863 0.9968601309813545 1.3236673554753677 0.9994610514578837 0.00241456352487709 0.08203016025802753 0.030058334536830347 0.0027507230918687444 0.014850356566257203 1.1124799471325003e-07 6.95370780859709 0.3268072244940132 KSDGIYIINLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSDGIYIINLK 11 1 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 9200000.0 3318700.0 2446100.0 3435200.0 False True 4350847.838336517 2081151.4148231184 3079758.456765197 1.0 0.47833238305544057 0.7078524855842115 22.052865131889597 -10.324501511621861 5.794461400319642 1.0000495844896877 0.5930924343198257 0.8073485566578653 0.09370118948446693 6.002865021520324e-05 6.997923556978299e-06 0.09073680118938326 0.030241928866096352 4.7369465941214874e-11 10.324501511621861 -0.406957150169862 KSDGIYIINLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSDGIYIINLK 11 1 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 8172600.0 2928600.0 932300.0 4311700.0 False True 2835633.196034589 1304572.251880272 3182336.4217726346 1.0 0.4600638240886072 1.1222665985935287 21.435239493831467 -6.6899052185092795 1.8666190826141982 0.6614645271195698 1.1199828526697404 0.37001746142134495 0.22835946283602335 0.41688628999075034 2.8161199450477117 0.09786883120575723 0.25490024116873394 2.04218358718327e-07 6.6899052185092795 0.4585183255501706 KSDGIYIINLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSDGIYIINLK 11 1 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 8391100.0 3318700.0 2532000.0 2540400.0 False True 4545713.074495291 2420127.8677956928 1940409.8411803104 1.0 0.5323978500478495 0.42686588646947393 22.116075193412488 -13.999999999999998 0.20916467453667031 3.695068036035676 0.3642019418330908 0.9994895595058946 0.005626959602007485 12.727279222474733 0.14496522192387307 14.090708855232936 0.06287985324424362 1.0000000000000041e-14 13.999999999999998 -3.330866094202585 KSDGIYIINLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSDGIYIINLK 11 1 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 5387800.0 2928600.0 1468100.0 991100.0 False True 2435260.6589779067 1460191.0539049667 1198334.4276713587 1.0 0.5996035982931772 0.4920764531934363 21.215644769265744 -13.999999999999961 0.1845215730405125 3.1073191305247594 0.41053405512481195 0.9994933760310887 0.004919123279693972 12.26659905561343 0.13620540735961695 9.278439005407762 0.07730178957684794 1.00000000000009e-14 13.999999999999961 -2.6967850753999474 KSDIYVCMISFAHNVAAQGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSDIYVCMISFAHNVAAQGK 20 1 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 4876000.0 1069300.0 2253400.0 1553300.0 False True 1401862.6551159313 1917201.5036844015 1392579.4163057115 1.0 1.3676100841175862 0.9933779255932514 20.418913580235227 -6.650277874212413 2.007782298541085 1.2384927414125517 0.99495803176544 0.1951121886272319 0.15688986345175449 0.5078295338766565 3.9243492012234 0.06336965006423226 0.17375254141794333 2.237289197965349e-07 6.650277874212413 -0.24353470964711177 KSDIYVCMISFAHNVAAQGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSDIYVCMISFAHNVAAQGK 20 1 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 28996400.0 6637000.0 9842400.0 12517000.0 False True 10068814.229693938 8085946.820977802 10043009.463604007 1.0 0.8030684285674412 0.9974371593813073 23.263390456228706 -10.799929732055421 8.771112940130317 1.0017541301908774 0.900252793977977 0.2598873954111661 0.0793507020743916 0.002766320655234647 6.310010341232482e-05 0.07808536183725993 0.025610328970332066 1.5851496456320095e-11 10.799929732055421 -0.10150133621290047 KSDIYVCMISFAHNVAAQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSDIYVCMISFAHNVAAQGK 20 1 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 6763400.0 1069300.0 2244400.0 3449700.0 False True 1464649.1067459604 2145234.986761709 2634951.9088016525 1.0 1.4646750384655747 1.7990328855324103 20.48212364175812 -6.974692828601072 0.09279811622376484 0.0669289171069975 3.2052249843266085 0.9999998134683418 0.0001413905517982941 0.07480716538850406 0.0027115973777647327 0.033282487779656124 0.05791657291427021 1.0600031879389366e-07 6.974692828601072 3.138296067219611 KSDIYVCMISFAHNVAAQGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSDIYVCMISFAHNVAAQGK 20 1 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 33346900.0 6637000.0 13347000.0 13362900.0 False True 8591727.334829 12604227.71704406 10930989.314932708 1.0 1.4670190551729048 1.2722691129431967 23.034516778321155 -10.127422018428081 4.464306859460613 0.999956216557521 1.3696440840729134 0.8276881454055895 0.07950633105324031 3.721663711046863e-05 7.274127976715248e-06 0.07699144841425606 0.02566055799722363 7.457237615726701e-11 10.127422018428081 0.3696878675153924 KSDVEAIFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSDVEAIFSK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 59666200.0 8748200.0 27553000.0 23365000.0 False True 11468974.917689301 23442199.800752785 20947413.93290607 1.0 2.0439664371919104 1.82644169014596 23.451233115089735 -10.150151580564307 5.774299190728604 0.9999884248714268 1.9352040636689731 0.9610065046721686 0.08880410611524021 1.3236412723209587e-05 1.9480285093153108e-06 0.08598526867773214 0.028661402004908725 7.076987352021885e-11 10.150151580564307 0.9352156387975463 KSDVEAIFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSDVEAIFSK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 36948000.0 10485000.0 3912000.0 22551000.0 False True 10152159.414198834 5474082.000810502 16644216.584501415 1.0 0.5392037080460378 1.6394754953535082 23.275283292587947 -6.792932209701477 1.4844936397432411 0.7434411228644855 1.6521589511598118 0.8107215699883025 0.19627973536567267 0.23100394673805968 1.0055721753914917 0.1040536608346733 0.24311611041387501 1.6108970651987056e-07 6.792932209701477 0.9087178282953263 KSDVEAIFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSDVEAIFSK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 140992600.0 2916700.0 135510000.0 2565900.0 False True 4424847.139332271 111327181.75553757 2058748.740326078 1.0 25.159554273853928 0.4652700252684327 22.07719618607089 -11.365808521122972 1.959135503782518e-10 8.737942564403594 14.52439790672817 0.0 11.842244758985427 0.0 0.7830178190955291 525740859.1801493 525740852.7305644 4.307164699788756e-12 11.365808521122972 5.786455342324576 KSDVEAIFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSDVEAIFSK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 57049200.0 8748200.0 27286000.0 21015000.0 False True 11982645.95121574 26080414.29726433 16051689.817510722 1.0 2.1765154710774253 1.3395780767337238 23.514443176612627 -10.194692082028988 4.873725177443487 0.99990987474046 1.7580467739073786 0.5224034175410733 0.3416782604723241 0.0003346397656181792 5.529411068350036e-05 0.33086753976285355 0.11027618437998198 6.38716180143378e-11 10.194692082028988 0.7581368991669186 KSDVEAIFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSDVEAIFSK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 15192400.0 10485000.0 2252600.0 2454800.0 False True 8718742.064257115 2240464.796693911 2968087.3302872125 1.0 0.2569711066323202 0.3404260968397062 23.055688568022223 -10.58150909204844 6.457120054303242 1.0013920622951624 0.29869860176287494 0.9894908337429311 0.03407035708284376 0.000683833828885351 4.43197342692519e-05 0.03303975714754407 0.010996160465099483 2.6211441638436867e-11 10.58150909204844 -0.7026934605322874 KSDVEAIFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSDVEAIFSK 10 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 10973500.0 2916700.0 4424700.0 3632100.0 False True 3775725.6467524064 4178461.5553761018 2971095.0684931437 1.0 1.106664505396492 0.7868937911441354 21.84832250816334 -6.816766825161856 1.3857078088229888 1.0576876584020256 0.7803802049791043 0.8767974705858973 0.04666039430559006 0.19772286603730196 0.7468606056321979 0.026465809397091398 0.06106110677973934 1.5248712449046594e-07 6.816766825161856 -0.2773074534229213 KSDVEAIFSK(ub)YGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSDVEAIFSKYGK 13 2 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 47802000.0 11559000.0 24106000.0 12137000.0 True False 15153960.937515235 20509478.764452063 10881179.66632489 1.0 1.353407128936084 0.7180419502987748 23.853191598373666 -6.755724817615033 1.6284437406401793 1.2063650837567712 0.71618928690491 0.6733192182215924 0.14856721670880327 0.2901606918129871 1.5154571168415416 0.07201716448535213 0.17381525632073613 1.7549921668034768e-07 6.755724817615033 -0.4901757968518612 KSDVEAIFSK(ub)YGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSDVEAIFSKYGK 13 2 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 55709000.0 18618000.0 16829000.0 20262000.0 True False 18026981.780977953 23548907.46207561 14954774.353029493 1.0 1.3063144872606676 0.8295772711552719 24.103654533853867 -6.733231167188714 1.7117917099270035 1.1836778575938918 0.8297084391863963 0.5740098284128472 0.12873781206580337 0.3302238912118545 1.8971644337401585 0.059567415302713214 0.14725551132274925 1.8482845482769383e-07 6.733231167188714 -0.3539694184074955 KSDVEAIFSK(ub)YGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSDVEAIFSKYGK 13 2 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 47260000.0 11559000.0 14006000.0 21695000.0 True False 15832674.670229634 13387168.60835169 16571087.822550315 1.0 0.8455405600876611 1.0466385603001829 23.916401659896557 -6.701531820317586 1.8254161392684842 0.9042285784585649 1.0460567167724775 0.42476463702906353 0.06518161037219107 0.39238859793460656 2.543012154600544 0.028475466885423417 0.0730929807386095 1.988237128935661e-07 6.701531820317586 0.1418281383139126 KSDVEAIFSK(ub)YGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSDVEAIFSKYGK 13 2 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 57637000.0 18618000.0 27584000.0 11435000.0 True False 15481691.917247394 27435399.51700467 13826005.63053375 1.0 1.7721189430491273 0.8930552102726494 23.884059809288143 -6.6747413920675305 1.9208463495580983 1.4908193930177305 0.8965449181519728 0.3001481124553699 0.32762547711546747 0.4502883873355689 3.207468952375213 0.13710414087647577 0.36402079843154583 2.1147479271046936e-07 6.6747413920675305 -0.5942744748657577 KSDVEAIFSK(ub)YGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSDVEAIFSKYGK 13 2 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 130086000.0 30840000.0 35695000.0 63551000.0 True False 39922987.94728434 33708541.87157324 51985370.0883258 1.0 0.8443391540754198 1.3021412665046272 25.25071636423073 -6.814948349444894 1.3934121976479399 0.9156420258514733 1.3111050137471616 0.8723749415122869 0.06789797481274475 0.20015140449237673 0.7648912340045636 0.03830205488003976 0.08842822039321277 1.5312695644334315e-07 6.814948349444894 0.39546298789568834 KSDVETIFSK(ub)YGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSDVETIFSKYGR 13 2 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2 Q5QPL9 RALY RNA-binding protein Raly 1 9023800.0 2128600.0 4029200.0 2866000.0 True False 2790615.213391722 3428059.065698585 2569453.812613259 1.0 1.2284241300082757 0.9207481562785351 21.412151780076382 -6.7078712477553735 1.802619977783514 1.1407335555178257 0.921510192199735 0.4550475121242479 0.09628933738492161 0.3793797938391985 2.401692039306201 0.042528073147406614 0.10832811534525937 1.9594254845630387e-07 6.7078712477553735 -0.21922336331809078 KSDVETIFSK(ub)YGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSDVETIFSKYGR 13 2 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2 Q5QPL9 RALY RNA-binding protein Raly 1 12250400.0 3184200.0 5381900.0 3684300.0 True False 3083119.3139429614 7530920.736237725 2719271.3033691873 1.0 2.4426303264295433 0.8819870483350015 21.5559592908494 -6.663755487922376 1.959197054216547 1.9256848755150846 0.8883867038601169 0.25188648457822926 0.6136856271153407 0.47557411389757515 3.512909260178687 0.25270153302907916 0.6807782267277566 2.16892488723912e-07 6.663755487922376 -1.0372981716549678 KSDVETIFSK(ub)YGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSDVETIFSKYGR 13 2 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2 Q5QPL9 RALY RNA-binding protein Raly 1 34818800.0 5196900.0 8640900.0 20981000.0 True False 7884077.244281512 7098863.88334016 16834096.153701015 1.0 0.900405166437089 2.135201829219918 22.91051048058583 -6.887368411017441 1.037858391497033 0.929406717615653 2.2360745363082954 0.9791584932675523 0.08085814000920204 0.12130287706201448 0.23454527716721132 0.05955922091993619 0.14713823048467878 1.2960793433690318e-07 6.887368411017441 1.3066678186926426 up KSDVETIFSK(ub)YGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSDVETIFSKYGR 13 2 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2 Q5QPL9 RALY RNA-binding protein Raly 1 9079000.0 2128600.0 3551800.0 3398600.0 True False 2915600.9432520797 3394869.7317680637 2595920.676364118 1.0 1.164380790733798 0.890355273883473 21.475361841599273 -6.744234302444447 1.6709819811766866 1.0973221928645147 0.8900347445079585 0.6238801671223392 0.06906332241089232 0.3102110672378715 1.7022107526004444 0.03267480896253665 0.07981798834285628 1.8020452727633965e-07 6.744234302444447 -0.20728744835655621 KSDVETIFSK(ub)YGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSDVETIFSKYGR 13 2 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2 Q5QPL9 RALY RNA-binding protein Raly 1 10494200.0 3184200.0 4742400.0 2567600.0 True False 2647803.383977828 4716851.749907299 3104473.2887589405 1.0 1.7814206970387332 1.1724712293761976 21.336364566283677 -10.123157387643003 4.496911099253638 0.9999557135259668 1.4769459627905503 0.44992292674625733 0.24860257927548526 173445647.31406876 10.314399722824518 97649.5223508884 0.08510327530785503 7.530825983163111e-11 10.123157387643003 0.47699024926458355 KSDVETIFSK(ub)YGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSDVETIFSKYGR 13 2 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2 Q5QPL9 RALY RNA-binding protein Raly 1 24632600.0 5196900.0 6569700.0 12866000.0 True False 6727489.496214073 6204090.41976956 10524520.016308136 1.0 0.9221999414879714 1.564405269191555 22.68163680267828 -6.876619749322533 1.0985180243996944 0.9536377979235467 1.607060726862536 0.9708531934291189 0.048856004381670703 0.13066448620177662 0.29076143905346674 0.0343583724646929 0.08241635963937564 1.3285571795544031e-07 6.876619749322533 0.6534229289389893 KSEIEYYAMLAK(ub)TGVHHYSGNNIELGTACGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSEIEYYAMLAKTGVHHYSGNNIELGTACGK 31 2 P62888;E5RI99 P62888 RPL30 60S ribosomal protein L30 1 178697500.0 93431500.0 69165000.0 16101000.0 True False 141742416.2575935 56821965.361388445 12918630.292681001 1.0 0.40088187334216085 0.09114159779245978 27.078696306821968 -8.70434476919952 0.3513886996909316 1.1550017834494697 4.033812037648061e-24 0.9978692835710079 0.017414060015332876 0.28240272565737823 0.11314945372162144 0.14175376952295674 0.08437292414705704 1.9754008249568583e-09 8.70434476919952 -1.1550017834494697 KSGVGNIFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSGVGNIFIK 10 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;Q4VXU2;E5RH24;Q4VXU2-2;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC1L;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 5 0 7601300.0 2080000.0 1476300.0 4045000.0 False True 2726900.1427486525 1256041.7945723294 3626462.2023798404 1.0 0.4606115841507376 1.329884488811699 21.378830440021414 -6.738873463701715 1.690715438062118 0.6786465296735168 1.3302802130317184 0.5999022773224842 0.22663541874353138 0.31986583721668294 1.7948614101139695 0.10606090150576769 0.260597060684099 1.82442719107882e-07 6.738873463701715 0.6516336833582016 KSGVGNIFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSGVGNIFIK 10 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;Q4VXU2;E5RH24;Q4VXU2-2;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC1L;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 5 0 11277600.0 3146100.0 3401900.0 4729600.0 False True 3046228.7775880736 4760296.41067414 3490775.8750413693 1.0 1.5626851291330854 1.1459335886798616 21.538592864365906 -10.45280039918069 5.808558951932135 0.9997650683741194 1.3543093589064739 0.49076167369757384 0.17013810393821088 0.0005179606012443101 4.8794802990561645e-05 0.16484310306767075 0.05491183692566632 3.525328571660406e-11 10.45280039918069 0.3545442905323545 KSGVGNIFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSGVGNIFIK 10 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;Q4VXU2;E5RH24;Q4VXU2-2;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC1L;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 5 0 5887200.0 2080000.0 1807300.0 1999900.0 False True 2849032.209886463 1727447.510058119 1527564.809233389 1.0 0.6063278274158086 0.5361697224526164 21.442040501544305 -13.999999999999998 0.24260082597837382 3.638959726208272 0.50590590961917 0.999529352503526 0.0044285765837566255 13.716662748298765 0.1558794335720369 17.562950635306184 0.03376574116119884 1.0000000000000041e-14 13.999999999999998 -3.133053816589102 KSGVGNIFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSGVGNIFIK 10 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;Q4VXU2;E5RH24;Q4VXU2-2;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC1L;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 5 0 9882800.0 3146100.0 5345500.0 1391200.0 False True 2616121.5458616414 5316702.730501326 1682093.4878179757 1.0 2.0322842946313586 0.6429722237022303 21.318998139800183 -6.707696819550791 1.8031847953102484 1.6360865013305328 0.6464079435322941 0.4543410471147207 0.4351550168405866 0.37967997600121495 2.4049754989963357 0.1921413315054081 0.48953950136544905 1.9602126180129714e-07 6.707696819550791 -0.9896785577982387 KSLSDSESDDSK(ub)SK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSLSDSESDDSKSK 14 2 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 6352400.0 2639600.0 2290100.0 1422700.0 True False 3460541.161922766 1948426.0067398828 1275492.6515020512 1.0 0.5630408411779408 0.3685818465437222 21.722566234519533 -13.999999999996225 0.10963204686408186 3.109743515302763 0.00995708974581682 0.9997449317789098 0.004216881546996981 12.014842785060281 0.1004145549706528 5.614670734415405 0.3185636689325479 1.0000000000086917e-14 13.999999999996225 -3.099786425556946 KSLSDSESDDSK(ub)SK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSLSDSESDDSKSK 14 2 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 3182550.0 1460100.0 1012800.0 709650.0 True False 1214137.8433974062 1007343.8453749408 858034.533949128 1.0 0.8296783193547337 0.7067027344672593 20.211500792150563 -6.974660518108432 0.09492700924826143 1.3308918479001373 0.20237910559748104 0.9999997929315284 5.44172699240418e-05 0.07481725110137545 0.002777453619396945 0.011884488872215064 0.020945012857679437 1.060082052627973e-07 6.974660518108432 -1.1285127423026562 KSPNLSK(ub)CGEELGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSPNLSKCGEELGR 14 2 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 28628300.0 7994100.0 14056000.0 6578200.0 True False 10480342.51497452 11958899.58985888 5897550.966550086 1.0 1.14107907950258 0.5627250214507349 23.321182531523956 -6.842238014272661 1.2720632331935933 1.0750401389492856 0.5428565690615949 0.9282170870898102 0.0659673294853415 0.16620269701182946 0.5214642900633724 0.040649234960097286 0.09370628417256562 1.438010263442469e-07 6.842238014272661 -0.5321835698876908 KSPNLSK(ub)CGEELGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSPNLSKCGEELGR 14 2 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 20537700.0 9329100.0 7498600.0 3710000.0 True False 9032952.826991158 10492830.084682407 2738239.7023857157 1.0 1.161616836227576 0.3031389352774704 23.106766243906257 -6.858017157447886 1.19578791840358 1.0872598761699674 0.26312868260525984 0.9511790379071859 0.08230275713941958 0.1488551147021459 0.4055989890194945 0.05372528063500987 0.12513808922357905 1.3867010441074726e-07 6.858017157447886 -0.8241311935647075 down KSPNLSK(ub)CGEELGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSPNLSKCGEELGR 14 2 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 99022000.0 31467000.0 42286000.0 25269000.0 True False 47737739.54584588 34739732.91797402 20274571.074203853 1.0 0.7277205256987719 0.4247073964349059 25.508626918456798 -6.969743959184383 0.2642320449623067 1.0807936825767521 0.062594276025893 0.9999803150144647 0.0010425107338075566 0.07638589441302214 0.009327108296369494 0.006156733286194429 0.028412139852024787 1.0721512118753709e-07 6.969743959184383 -1.018199406550859 down KSPNLSK(ub)CGEELGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSPNLSKCGEELGR 14 2 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 23493200.0 7994100.0 7398000.0 8101100.0 True False 10949734.802429505 7071131.89808551 6187787.0273916805 1.0 0.6457811102892266 0.5651083920332707 23.384392593046847 -13.999999999999988 0.20787888467711715 3.0309255551246093 0.5166035543616884 0.9994889300484301 0.004270171481053233 12.697905515258968 0.14452782097037625 10.522321039546927 0.04850682238822958 1.0000000000000286e-14 13.999999999999988 -2.514322000762921 KSPNLSK(ub)CGEELGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSPNLSKCGEELGR 14 2 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 23380300.0 9329100.0 9213900.0 4837300.0 True False 7757559.999204674 9164262.891884046 5848757.064851842 1.0 1.1813331631110287 0.7539428719148125 22.887171519340534 -6.7914216188928815 1.490563210514836 1.1011600458746982 0.749212275305933 0.8059224003379881 0.0771596842476939 0.23323894013325142 1.0236818150414273 0.040741436419686215 0.09529136352416162 1.6165099461526017e-07 6.7914216188928815 -0.35194777056876514 KSPVAK(ub)DVDLEFLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KSPVAKDVDLEFLAK 15 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 422398000.0 194570000.0 179642000.0 48186000.0 True False 255083154.2185605 152840113.83903164 43200174.95275035 1.0 0.5991776066406764 0.16935722425533264 27.926392385096026 -7.628476284347308 0.40125466947942523 1.0423649855172963 4.236974193861461e-22 0.9984956220302978 0.013155437766152307 0.12073345971604323 0.058571987073953474 0.025003841481138416 0.0729818724497771 2.3524679518243785e-08 7.628476284347308 -1.0423649855172963 down KSPVAK(ub)DVDLEFLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSPVAKDVDLEFLAK 15 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 458664000.0 356010000.0 18781000.0 83873000.0 True False 344708657.4200218 26280351.24162115 61904145.16393457 1.0 0.07623931304283715 0.17958395831209253 28.360802291804912 -10.433579437900564 6.029343571070912 1.0003352866930855 0.12791163567746464 0.9895776388425391 0.042190274759768616 0.0001902208200974194 1.7870085981025166e-05 0.0408653707242879 0.013616852626374805 3.6848563504971784e-11 10.433579437900564 -0.8724236510156208 KSPVAK(ub)DVDLEFLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSPVAKDVDLEFLAK 15 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 1105581000.0 523540000.0 403564000.0 178477000.0 True False 794248455.9008532 331544851.1400765 143200942.72075185 1.0 0.4174321632945845 0.18029741406085625 29.56501513929565 -10.226743352004343 0.2107725944625207 1.6864174026612173 2.450474498131212e-20 0.9993336797969976 0.008890174612117583 1.810708641886061 0.10141409906363474 0.8170438512463783 0.1323019715089595 5.932758196356994e-11 10.226743352004343 -1.6864174026612173 KSPVAK(ub)DVDLEFLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSPVAKDVDLEFLAK 15 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 253901700.0 194570000.0 13778000.0 45553700.0 True False 266507787.05654308 13169242.402246855 34794854.267900966 1.0 0.04941409985687521 0.13055849006212636 27.989602446618917 -10.204671625004773 4.240200620050387 1.0003857665595242 0.08998629490991833 0.9940721076928621 0.033127058749263014 334288510.9420546 609571107.4434892 1691042.8999275002 0.011755818294378361 6.242066268236419e-11 10.204671625004773 -0.9103994716496058 KSPVAK(ub)DVDLEFLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSPVAKDVDLEFLAK 15 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 705104600.0 356010000.0 306317000.0 42777600.0 True False 296038088.91713655 304666809.52183574 51722198.37872495 1.0 1.0291473324809715 0.17471467461473314 28.14120756723919 -6.899002803811394 0.9675647306851436 1.0365027117991075 0.08682638245198948 0.9860632113100478 0.04676032711361247 0.11214254020504938 0.1815947640762919 0.03631361212512347 0.0940164409579942 1.261819388240336e-07 6.899002803811394 -0.949676329347118 down KSPVAK(ub)DVDLEFLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSPVAKDVDLEFLAK 15 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 1166554000.0 523540000.0 543392000.0 99622000.0 True False 677732850.5162532 513151757.52004236 81491818.20804057 1.0 0.7571593395969465 0.12024180050585617 29.3361414613881 -7.202545738541199 0.6220342579231424 1.0004808924618653 4.233355278681542e-22 0.9975729265052083 0.018276266543479747 0.08788342941655694 0.05949759746747328 0.017515188202701246 0.05419315739613845 6.272696304228256e-08 7.202545738541199 -1.0004808924618653 down KSWPEPDQK(ub)PEPVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KSWPEPDQKPEPVDK 15 2 Q96S82;H3BV23 Q96S82 UBL7 Ubiquitin-like protein 7 1 9486800.0 2028000.0 1912200.0 5546600.0 True False 1963622.250071077 2675751.431991263 4093779.0655667377 1.0 1.362660986294288 2.0848098789971217 20.905085988607333 -6.9601304632096905 0.4335907848728005 0.9723840182340044 2.5029449109747417 0.9997750084826992 0.006763438785795599 0.07965455101797372 0.020959317032092764 0.009450912937726827 0.05991243217446723 1.0961488606654687e-07 6.9601304632096905 1.5305608927407373 up KSWPEPDQK(ub)PEPVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSWPEPDQKPEPVDK 15 2 Q96S82;H3BV23 Q96S82 UBL7 Ubiquitin-like protein 7 1 26594500.0 6525400.0 10805000.0 9264100.0 True False 9899508.87064106 8876763.330149679 7433046.574400731 1.0 0.8966872444021405 0.7508500342319903 23.23892552204507 -6.9662477502418225 0.33596540334658553 1.0165760116632792 0.6261442786266868 0.9999365855920483 0.0008138917649981213 0.07754023355243847 0.013381816546350202 0.0020851068469486486 0.012660907773624394 1.0808172059156283e-07 6.9662477502418225 -0.3904317330365924 KSWPEPDQK(ub)PEPVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KSWPEPDQKPEPVDK 15 2 Q96S82;H3BV23 Q96S82 UBL7 Ubiquitin-like protein 7 1 6649800.0 1808100.0 1543100.0 3298600.0 True False 2476603.4320652466 1474920.7396506846 2519538.6167994705 1.0 0.5955417490561838 1.0173363180307071 21.239931443804092 -10.978842313037196 12.239134913884559 1.1066267000681291 0.8064390336113009 0.21922821338850618 0.1721969117107911 0.07801170230635379 0.0001348580519560484 0.025961337628423575 0.05557631427702024 1.0499235737365728e-11 10.978842313037196 -0.30018766645682826 KSWPEPDQK(ub)PEPVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KSWPEPDQKPEPVDK 15 2 Q96S82;H3BV23 Q96S82 UBL7 Ubiquitin-like protein 7 1 8212300.0 2028000.0 3873900.0 2310400.0 True False 1686371.8556331364 3853030.5317910565 2793493.9579173704 1.0 2.2848048127229115 1.6565112543748977 20.68549126404161 -10.065931510383978 5.624544891897656 0.9999945880211858 1.970658033549174 0.7608991708885176 0.2564997711059847 1.7407118744934805e-05 2.8914763912706425e-06 0.2483562182938969 0.08278494514981952 8.59149001342365e-11 10.065931510383978 0.9706634455279881 KSWPEPDQK(ub)PEPVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KSWPEPDQKPEPVDK 15 2 Q96S82;H3BV23 Q96S82 UBL7 Ubiquitin-like protein 7 1 33056800.0 6525400.0 7726400.0 18805000.0 True False 8447258.934864106 7296419.047948553 15382682.955594163 1.0 0.8637617367018635 1.8210265689981042 23.010051844137518 -6.870822324375421 1.1296632976525536 0.9225426359800513 1.8779896863289176 0.965500733688613 0.0785347546899414 0.13607262838734013 0.3240336321738593 0.05392361274174767 0.12785886352644665 1.3464110759982377e-07 6.870822324375421 0.9554470503488663 KSWPEPDQKPEPVDK(ub)VAAMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KSWPEPDQKPEPVDKVAAMR 20 3 Q96S82;H3BV23 Q96S82 UBL7 Ubiquitin-like protein 7 1 18085900.0 4372500.0 6370400.0 7343000.0 True False 6633402.172568435 5233552.34783762 5891652.831448775 1.0 0.7889695531322207 0.8881796517348115 22.6613175661449 -10.077121525581322 4.5589021207570575 1.0000097767334868 0.8385746025103835 0.7792478592432481 0.040502353173855844 4.123131474958718e-06 8.346940477947452e-07 0.03921866751972871 0.01307207827386255 8.372949549638878e-11 10.077121525581322 -0.16143517422310327 KTAMAAAK(ub)APTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTAMAAAKAPTK 12 2 P83731 P83731 RPL24 60S ribosomal protein L24 1 1954520.0 308650.0 1061400.0 584470.0 True False 468244.61533750704 871984.8772439488 468949.2483176988 1.0 1.8622421885522995 1.001504839473026 18.836902878471513 -10.263593711923054 3.9890465614753934 0.9995041290836643 1.4318735135668195 0.25131123100478947 0.3513945514685624 124281436.41890018 481.33013278807874 569227.4349735088 0.12029170149040024 5.4501228042601124e-11 10.263593711923054 0.4323693844831552 KTCPICK(ub)QPVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTCPICKQPVHR 12 2 I3L0L6;Q9H6Y7 I3L0L6 RNF167 E3 ubiquitin-protein ligase RNF167 1 16492400.0 4358000.0 8142400.0 3992000.0 True False 5713380.202932028 6927585.658826604 3578946.1339679467 1.0 1.2125196315959268 0.62641483795027 22.445913108108865 -6.808622262122353 1.420453819492203 1.1160124521279369 0.6164951692415968 0.8561539516961798 0.09188554083341986 0.20869404925551505 0.8301896233634944 0.05086921063854304 0.1177386433199556 1.5537378225712628e-07 6.808622262122353 -0.4995172828863401 KTCPICK(ub)QPVHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTCPICKQPVHR 12 2 I3L0L6;Q9H6Y7 I3L0L6 RNF167 E3 ubiquitin-protein ligase RNF167 1 14675900.0 5592200.0 4921100.0 4162600.0 True False 8483776.24458255 4042891.256270202 3339860.2854676093 1.0 0.4765438337499594 0.39367614010333307 23.016275140323703 -13.999999999999998 0.25943755043526373 4.8207375036474325 0.363224976327178 0.9995611881460125 0.005623068366990837 14.392233324204094 0.16118067738641068 28.819386644919337 0.036336076645412475 1.0000000000000041e-14 13.999999999999998 -4.4575125273202545 KTCPICK(ub)QPVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTCPICKQPVHR 12 2 I3L0L6;Q9H6Y7 I3L0L6 RNF167 E3 ubiquitin-protein ligase RNF167 1 12533000.0 4358000.0 4261500.0 3913500.0 True False 5969270.370521729 4073212.8391040047 2989211.901062491 1.0 0.6823636033004811 0.5007667127668112 22.509123169631756 -10.80366404326369 0.09597141161347023 1.9571706375286657 3.8860296524408027e-13 0.9999140254761298 0.0019130226237428108 2.9453015651147023 0.055675638407277496 0.9438029127645055 0.3113424463205539 1.5715780582559697e-11 10.80366404326369 -1.9571706375282771 KTCPICK(ub)QPVHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTCPICKQPVHR 12 2 I3L0L6;Q9H6Y7 I3L0L6 RNF167 E3 ubiquitin-protein ligase RNF167 1 11930200.0 5592200.0 3168700.0 3169300.0 True False 7239213.1387420045 2992359.0594888353 2592519.9197641383 1.0 0.4133541867243369 0.35812178341452366 22.787401462416152 -13.999999999999998 0.334240433251836 7.551730546095121 0.3488191623782636 0.9997235746663297 0.004828906163511743 19.187756262617985 0.18510812039656827 88.56548991964503 0.017423914740859362 1.0000000000000041e-14 13.999999999999998 -7.202911383716858 KTCTTVAFTQVNSEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTCTTVAFTQVNSEDK 16 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 6454800.0 1593400.0 2489500.0 2371900.0 False True 2088962.8305075513 2118076.303994996 2126478.5408713827 1.0 1.0139368078082898 1.017959012872774 20.99435539168635 -13.99999063769297 0.1742587130054971 0.928898665575082 1.0213508594845295 0.9995056361511657 0.00017099898264312402 12.136353514245524 0.1322711304107947 0.2918441754890304 0.0031564855392771612 1.0000215577409662e-14 13.99999063769297 0.09245219390944748 KTCTTVAFTQVNSEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTCTTVAFTQVNSEDK 16 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 4816800.0 1593400.0 1480100.0 1743300.0 False True 2182523.0400159108 1414704.2879638248 1331568.4443905049 1.0 0.6481967255445383 0.6101051031199183 21.057565453209243 -13.99999999999994 0.3139580807185 4.480557983233302 0.6020222899112994 0.9996806598263097 0.003136378453668314 17.55636938205108 0.1784349710879639 40.00598832283233 0.01298957495671606 1.000000000000139e-14 13.99999999999994 -3.8785356933220028 KTCTTVAFTQVNSEDKGALAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTCTTVAFTQVNSEDKGALAK 21 2 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 15155400.0 4813700.0 6633700.0 3708000.0 False True 6310807.315937106 5643977.817960071 3324331.729647578 1.0 0.8943353101126943 0.5267680604433002 22.58939314445234 -6.948084653838651 0.5794899237829699 1.0044021247609252 0.398536706440322 0.9990422763973102 0.006276652907997205 0.08426408891742977 0.039216554243195284 0.006579926492119346 0.03070074306731355 1.1269777612536366e-07 6.948084653838651 -0.6058654183206031 KTCTTVAFTQVNSEDKGALAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTCTTVAFTQVNSEDKGALAK 21 2 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 41057500.0 3725600.0 30521000.0 6810900.0 False True 5652007.577843558 25074289.088338584 5464722.629676488 1.0 4.436350932477928 0.9668639955648245 22.43033196926885 -6.648368956190347 2.0137893843944 3.232763716497799 0.9813154336290926 0.1874839878436254 1.4672735457559543 0.5126868825654808 3.98312487311374 0.5912060654974315 1.625630781676231 2.2471447260814951e-07 6.648368956190347 -2.2514482828687066 KTCTTVAFTQVNSEDKGALAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTCTTVAFTQVNSEDKGALAK 21 2 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 29378300.0 3725600.0 11928100.0 13724600.0 False True 4822862.642555204 11264290.749357399 11226863.626288116 1.0 2.335602646022997 2.327842291676796 22.2014582913613 -10.110664618655886 4.981679389270803 0.9999505655179904 2.3317224688546934 0.9999745324422671 0.003168151411852932 1.7395143939186115e-06 3.105446307185803e-07 0.0030676622573266392 0.0010225164689872674 7.750601023325443e-11 10.110664618655886 1.331771903336703 KTDPSSLGATSASFNFGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTDPSSLGATSASFNFGK 18 1 Q9UKX7;Q9UKX7-2 Q9UKX7 NUP50 Nuclear pore complex protein Nup50 0 13765600.0 4475500.0 4073000.0 5217100.0 False True 6130213.295839836 3893041.392390148 3984928.4295472405 1.0 0.6350580647874183 0.6500472719687492 22.54750584152683 -9.873173566426066 6.654013897701697 1.0000000113577718 0.6425526683860115 0.9986828887325099 0.006119318207237127 1.0283711429254098e-09 1.724918040528153e-10 0.005925004553249791 0.0019750014588903607 1.3391413906479662e-10 9.873173566426066 -0.3574473429717603 KTEHEPVIK(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTEHEPVIKSR 11 2 P21675-10;P21675-11;P21675-8;P21675-6;P21675-7;P21675-3;P21675-5;P21675-9;P21675;P21675-2;P21675-12;P21675-4 P21675-10 TAF1 Transcription initiation factor TFIID subunit 1 1 2341480.0 361810.0 821970.0 1157700.0 True False 474336.4137730246 699335.280013966 1037912.3094425566 1.0 1.4743444941349284 2.1881354230991206 18.8555510996606 -6.96520452275892 0.35453152337416244 0.9345195523959529 2.7522145698695244 0.9999172916702384 0.004441039706141801 0.07789170108143537 0.014616073361279326 0.009690774510886273 0.06117230825374375 1.0834165793507558e-07 6.96520452275892 1.8176950174735715 KTEHEPVIK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTEHEPVIKSR 11 2 P21675-10;P21675-11;P21675-8;P21675-6;P21675-7;P21675-3;P21675-5;P21675-9;P21675;P21675-2;P21675-12;P21675-4 P21675-10 TAF1 Transcription initiation factor TFIID subunit 1 1 3240290.0 670090.0 1090000.0 1480200.0 True False 648818.3597387213 1525242.6842749084 1092491.2149518423 1.0 2.350800746281475 1.68381673939034 19.307455118790458 -10.523341363400252 7.185910863906659 0.9996178567301511 2.017308742835907 0.7562044477918756 0.2722950805800432 0.0016676137401631548 0.0001106163386076714 0.2637370251479847 0.08788285936172617 2.996806048668582e-11 10.523341363400252 1.0176908861057559 KTEHEPVIK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTEHEPVIKSR 11 2 P21675-10;P21675-11;P21675-8;P21675-6;P21675-7;P21675-3;P21675-5;P21675-9;P21675;P21675-2;P21675-12;P21675-4 P21675-10 TAF1 Transcription initiation factor TFIID subunit 1 1 1808960.0 670090.0 637960.0 500910.0 True False 557209.5250203193 634523.1828548539 605647.9650538401 1.0 1.1387515007603564 1.0869303876881042 19.087860394224734 -10.342370096031228 4.889838358582612 0.9999313346176238 1.112840944224078 0.8634264236798357 0.021155880821843675 1.5847237463288663e-05 2.1313284630794024e-06 0.020496547292018757 0.006828031174755979 4.5460049467564507e-11 10.342370096031228 0.11290960960645424 KTEITDK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTEITDKLR 9 2 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3 Q9Y265 RUVBL1 RuvB-like 1 1 4639000.0 1255600.0 2160300.0 1223100.0 True False 1646103.7592476953 1837991.6607834469 1096545.344803655 1.0 1.1165709636818084 0.6661459453229119 20.65062384568771 -6.83800085388913 1.291686230804144 1.0620375382924812 0.6519112892394328 0.9209560280245823 0.053666553584467286 0.17114645123399 0.5555520998312874 0.03258957495904045 0.07504306800751737 1.4521087625178329e-07 6.83800085388913 -0.4101262490530484 KTEITDK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTEITDKLR 9 2 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3 Q9Y265 RUVBL1 RuvB-like 1 1 8809100.0 1780500.0 3783500.0 3245100.0 True False 1723979.0020964243 5294271.280691853 2395110.959086762 1.0 3.0709604201987477 1.3892924195562797 20.717310771967053 -6.594563897311471 2.2123542320201306 2.397674697489839 1.39454758073946 0.005075196872721288 0.8963843537196551 0.6561587826955981 6.061823704788434 0.3374398902369319 0.9976120798238686 2.5435255392375565e-07 6.594563897311471 -1.003127116750379 KTEITDK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTEITDKLR 9 2 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3 Q9Y265 RUVBL1 RuvB-like 1 1 4449200.0 1255600.0 1417800.0 1775800.0 True False 1719829.2513141544 1355156.9079623758 1356392.6137490147 1.0 0.7879601460010489 0.7886786509257062 20.713833907210603 -10.496587252720396 8.639770352433342 1.0000094691398784 0.7883193984633776 0.9999913558339095 0.000293328407181211 5.35043124682078e-08 3.117155281656012e-09 0.00028402670424190296 9.467133633186197e-05 3.187225176114313e-11 10.496587252720396 -0.2116900706765008 KTEITDK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTEITDKLR 9 2 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3 Q9Y265 RUVBL1 RuvB-like 1 1 8057900.0 1780500.0 4427400.0 1850000.0 True False 1480564.639524061 4403548.717429906 2236826.4465664565 1.0 2.9742360447332183 1.5107928332568457 20.49771604740133 -6.569458117955283 2.307928637455396 2.3527814749274696 1.5137057943112235 0.0 0.8599389812913724 0.731656648479386 7.314741273920105 0.31492576437709574 0.9645173437898996 2.694895207352689e-07 6.569458117955283 -0.839075680616246 KTEPWK(ub)EK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTEPWKEK 8 2 Q9C0F0;A0A2R8Y461 Q9C0F0 ASXL3 Putative Polycomb group protein ASXL3 1 38862000.0 13333000.0 14524000.0 11005000.0 True False 17479692.11695567 12357075.81410858 9866308.167414121 1.0 0.7069389856198871 0.5644440474923236 24.05917643799438 -13.999999999194065 0.09487951740821364 2.471755678535746 0.23532989220266398 0.9998190550452855 0.002439058342484679 12.12139908568676 0.09065600623351251 3.5425786587169714 0.29451651282080904 1.0000000018557336e-14 13.999999999194065 -2.2364257863330823 KTEPWK(ub)EK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTEPWKEK 8 2 Q9C0F0;A0A2R8Y461 Q9C0F0 ASXL3 Putative Polycomb group protein ASXL3 1 40003000.0 12164000.0 14450000.0 13389000.0 True False 11777860.478236955 20219960.355754517 9882019.238609804 1.0 1.7167770320523674 0.8390334778434273 23.489574152634788 -6.689636694400406 1.8680776442355533 1.4495329378074717 0.8421098379556398 0.36860136470696436 0.3031691383723666 0.41742574995959303 2.8240914565762485 0.12985440857100877 0.33825858533629616 2.0434466589373347e-07 6.689636694400406 -0.607423099851832 KTEPWK(ub)EK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTEPWKEK 8 2 Q9C0F0;A0A2R8Y461 Q9C0F0 ASXL3 Putative Polycomb group protein ASXL3 1 33523800.0 13333000.0 11984000.0 8206800.0 True False 18262570.410777032 11454507.254211517 6268522.864351514 1.0 0.627212215836388 0.3432442817935617 24.122386499517273 -7.807314972118275 0.2162320874175424 1.2035259389684403 3.289840111767824e-13 0.999845545675207 0.0033423157640339995 0.12383392553415074 0.03141686015752032 0.05508509034924612 0.08906943030619181 1.5584218472652894e-08 7.807314972118275 -1.2035259389681112 down KTEPWK(ub)EK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTEPWKEK 8 2 Q9C0F0;A0A2R8Y461 Q9C0F0 ASXL3 Putative Polycomb group protein ASXL3 1 31436600.0 12164000.0 12523000.0 6749600.0 True False 10114904.956568757 12455536.113379132 8160910.153375659 1.0 1.2314041671039466 0.8068202507504386 23.269979428069064 -6.758734135263845 1.6174503918246774 1.1346272677825178 0.805377682495349 0.6856714936071102 0.09731183633164363 0.28506173706280474 1.4695723315657359 0.047478250141007594 0.11423098823446 1.742873492512668e-07 6.758734135263845 -0.32924958528716874 KTETQEK(ub)NPLPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTETQEKNPLPSK 13 2 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 6659100.0 2850000.0 2417900.0 1391200.0 True False 2759528.3100111242 3383380.0791819254 1026802.984894611 1.0 1.2260718858754112 0.37209365860445615 21.395990255543456 -6.836301581809552 1.2992913506646169 1.1203903430156408 0.34597424264093085 0.9179206364608056 0.10350245647646744 0.17317518677210517 0.5694504593648757 0.06249604349246606 0.14388066041873543 1.4578015853671887e-07 6.836301581809552 -0.7744161003747099 down KTETQEK(ub)NPLPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTETQEKNPLPSK 13 2 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 4432700.0 1552300.0 1859200.0 1021200.0 True False 2126227.2593301716 1777054.396447768 780013.5922741821 1.0 0.8357782022828528 0.3668533496837544 21.019864375217757 -6.952555728394791 0.5300476894961604 1.0073931252405854 0.17394948781473646 0.9993868650446722 0.006642857948551235 0.08247550452704708 0.03183909165066781 0.007410575103874875 0.038777792429210305 1.1154350102481401e-07 6.952555728394791 -0.8334436374258489 down KTETQEK(ub)NPLPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTETQEKNPLPSK 13 2 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 7351330.0 2850000.0 3906600.0 594730.0 True False 2369901.27640751 3885554.370400613 719085.2932791718 1.0 1.639542713901844 0.3034241554438166 21.176395530977732 -6.776541262597024 1.5492565423636284 1.3637555000921 0.29395072426739405 0.7549762388425797 0.2700880178828828 0.2559942945811514 1.213350488902274 0.13734134875842485 0.3250295137597656 1.6728566896618877e-07 6.776541262597024 -1.069804775824706 KTETQEK(ub)NPLPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTETQEKNPLPSK 13 2 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 7195000.0 3232500.0 2481600.0 1480900.0 True False 4184534.972101058 2343496.7784982827 1211391.3953171705 1.0 0.5600375654935944 0.2894924772749432 21.99663587412595 -8.593732799620675 0.20679192298299875 1.317334318814913 4.3206826799502595e-10 0.999644875543612 0.005517724229524372 0.2026557174636374 0.055680812432894626 0.16519276211242281 0.1265045598772235 2.5483976761295318e-09 8.593732799620675 -1.3173343183828448 down KTETQEKNPLPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTETQEKNPLPSK 13 2 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 0 5919060.0 2296600.0 799460.0 2823000.0 False True 2223695.690095285 1118688.5471288245 2083571.611815329 1.0 0.5030762761791785 0.9369859469062731 21.084527939926442 -10.239360866070749 8.034018014593038 1.0000002168309479 0.7200311115427261 0.35694840354954505 0.17714288129007408 6.880425209509217e-07 6.489742917565809e-08 0.1715179901836004 0.05717261909463786 5.762874128688318e-11 10.239360866070749 -0.2799691052882217 KTFDLYANVRPCVSIEGYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTFDLYANVRPCVSIEGYK 19 2 P50213-2;P50213;H0YLI6;H0YMU3;H0YKD0 P50213-2 IDH3A Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0 27118800.0 4446800.0 22672000.0 0.0 False True 5756470.259532553 21410283.269710258 0.0 1.0 3.7193422886629928 0.0 22.45675302335219 -6.710710596502214 1.7927418745610206 2.670580637704435 0.00858004767009237 0.46844911386601096 1.145788824143921 0.37364703325772103 2.34135074340716 0.5085355776272344 1.2907734761662801 1.946656855263859e-07 6.710710596502214 -2.6620005900343426 KTFSYAGFEMQPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTFSYAGFEMQPK 13 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 10169500.0 3766800.0 3164700.0 3238000.0 False True 4938311.277743092 2692539.095903981 2902962.8210892268 1.0 0.5452347866444186 0.5878452486729309 22.23558634640887 -9.98344314275094 7.304579797004053 1.000000016271522 0.5665400183259179 0.992804524025445 0.017395648279016077 4.6131982772990745e-09 6.356570850321338e-10 0.01684326464773672 0.005614421340092502 1.03885959962074e-10 9.98344314275094 -0.43345999794560397 KTFSYAGFEMQPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTFSYAGFEMQPK 13 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 18250400.0 2763200.0 10181000.0 5306200.0 False True 4191976.416979094 8364121.0054839365 4257427.244209916 1.0 1.995269098272136 1.0156133576910695 21.999199169977445 -6.6425196838096845 2.0356048813065035 1.6496028256272324 1.0197188366626302 0.16430048526204843 0.42557891872755027 0.5269989312126312 4.176702594610668 0.17008255661656835 0.47120051329800733 2.2776150096997725e-07 6.6425196838096845 -0.6298839889646022 KTFSYAGFEMQPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTFSYAGFEMQPK 13 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 10030600.0 3766800.0 2648200.0 3615600.0 False True 5159487.753942469 2531193.7675736765 2761669.7456194023 1.0 0.49059012992899154 0.5352604516813039 22.29879640793176 -9.991796139629153 7.390992657781734 1.0000000172174708 0.5129252918307177 0.9937313029952267 0.018236582489852604 5.161331327319708e-09 7.119941995955441e-10 0.017657495594966932 0.0058858316895780355 1.0190696330481282e-10 9.991796139629153 -0.4870747253867531 KTFTAWCNSHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTFTAWCNSHLR 12 1 A0A494C1A0;P35609-2;P35609;A0A494C166;A0A494C033;K7EP19;A0A494C0Q3;O43707;O43707-3;F5GXS2;P12814-2;P12814;P12814-3;P12814-4;Q08043 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1;ACTN3 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-3 0 6447100.0 3504500.0 1669700.0 1272900.0 False True 4800208.3555515 1595927.133040471 972267.2361984007 1.0 0.3324703877061423 0.2025468821731377 22.194665597449028 -13.999999999999973 0.23010953882564836 5.216054350910068 0.1394427651876232 0.9995099437268798 0.007733628766307742 13.294690171324437 0.15188607592781894 25.610780472879874 0.0673960019681273 1.0000000000000614e-14 13.999999999999973 -5.0766115857224445 KTFTAWCNSHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTFTAWCNSHLR 12 1 A0A494C1A0;P35609-2;P35609;A0A494C166;A0A494C033;K7EP19;A0A494C0Q3;O43707;O43707-3;F5GXS2;P12814-2;P12814;P12814-3;P12814-4;Q08043 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1;ACTN3 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-3 0 19821000.0 3023400.0 7273300.0 9524300.0 False True 3913850.90012385 6868534.46125545 7790975.127570631 1.0 1.754930025831618 1.9906162310179198 21.90015736623188 -10.783818584564237 0.2344852281853692 5.742368419505625e-13 2.1267864924279443 0.9992404150834202 0.011645177895669214 2.6219010913830747 0.12255101166604775 1.581521504134631 0.11728013216284973 1.6450587610209572e-11 10.783818584564237 2.12678649242737 KTGCNVLLIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTGCNVLLIQK 11 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 7111000.0 2246900.0 2438000.0 2426100.0 False True 2945707.659010551 2074259.903249566 2175070.4447944965 1.0 0.7041635299092442 0.7383863901569554 21.490182829357355 -9.972744492381562 7.016012320668066 1.0000000172956949 0.7212749601984433 0.9888195567997964 0.013971424190913406 3.779839827115156e-09 5.602614619711953e-10 0.013527774109868138 0.004509257767850355 1.0647692675954108e-10 9.972744492381562 -0.2787250570972516 KTGCNVLLIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTGCNVLLIQK 11 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 6774300.0 2246900.0 1355100.0 3172300.0 False True 3077639.6501893713 1295227.2012835462 2423068.0755693177 1.0 0.4208508300196383 0.7873137699601132 21.553392890880247 -10.122241573445402 5.318782506647281 1.00000849178038 0.6040822999896642 0.6088069378036728 0.14960786874989346 1.5065073048780379e-05 2.4862429689061533e-06 0.14486030060632588 0.048285732010706545 7.546723293803011e-11 10.122241573445402 -0.39592619179071575 KTGQAPGYSYTAANK(ub)NK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTGQAPGYSYTAANKNK 17 2 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 1 14570500.0 2302900.0 2227600.0 10040000.0 True False 3493667.66454153 1830067.3756817586 8055589.599311671 1.0 0.5238241159157067 2.3057687143716334 21.736310947607066 -6.83558993993157 1.3025957820562029 0.7463629956226272 2.359486411312109 0.916623216278595 0.2175146828468141 0.17401287456138265 0.5754142671994914 0.13102149441202895 0.3016044351740622 1.46019232055384e-07 6.83558993993157 1.6131234156894816 up KTGQAPGYSYTAANK(ub)NK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTGQAPGYSYTAANKNK 17 2 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 1 3036780.0 998780.0 1214800.0 823200.0 True False 1368055.957014617 1161126.1191936033 628777.1143361805 1.0 0.8487416857768174 0.45961359337106583 20.383695810700367 -6.954845164627224 0.5028473625322561 1.0076043500484315 0.28388600592649643 0.999528698912733 0.004941609186625504 0.08159654187239446 0.028347266888108676 0.00576466627721196 0.03210306188188271 1.1095703305664477e-07 6.954845164627224 -0.723718344121935 down KTGQAPGYSYTAANK(ub)NK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTGQAPGYSYTAANKNK 17 2 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 1 15460300.0 2302900.0 2446400.0 10711000.0 True False 2981149.446945559 2310255.6894415654 8761707.904140884 1.0 0.7749546711952394 2.939036791033069 21.507437269699516 -6.881226400583658 1.072899993598844 0.8581124466074311 3.0960792530158083 0.9746627916857085 0.15463511848765643 0.12655089136011907 0.2657491804499051 0.11089706491715051 0.26904100230187217 1.3145393754770094e-07 6.881226400583658 2.237966806408377 up KTLHTCLELLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTLHTCLELLR 11 1 F8W7U8;P49959-2;P49959;P49959-3;F5GXT0;F5H742;F5H256 F8W7U8 MRE11A Double-strand break repair protein MRE11A 0 8445400.0 1385100.0 3742400.0 3317900.0 False True 1793039.2544028403 3534132.1501660054 2714076.244528899 1.0 1.9710288781954328 1.5136736342299455 20.773975642311495 -10.216274236239745 4.854547759229844 0.9998835940299641 1.7423512562142196 0.7784068451443578 0.1867144964888727 0.00023527245996387235 3.798320508692469e-05 0.18081356979318836 0.060261844615657194 6.077511142629964e-11 10.216274236239745 0.7424676621842555 KTNLSAVVAAQSNWEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTNLSAVVAAQSNWEK 16 1 O76094;O76094-2;D6RDY6;R4GNC1 O76094 SRP72 Signal recognition particle subunit SRP72 0 5276100.0 1216200.0 1875300.0 2184600.0 False True 1594449.9776975533 1595512.549862147 1958558.5481629174 1.0 1.0006664192539474 1.2283599834164447 20.604627406293652 -6.907538512389251 0.9123065812957724 0.9923895592680334 1.2562899644882013 0.9899596370816208 0.010770989949562347 0.10606931755361661 0.14775279975140068 0.00871239066002749 0.023659897168276565 1.2372614671319894e-07 6.907538512389251 0.2639004052201679 KTNLSAVVAAQSNWEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTNLSAVVAAQSNWEK 16 1 O76094;O76094-2;D6RDY6;R4GNC1 O76094 SRP72 Signal recognition particle subunit SRP72 0 3977700.0 1216200.0 1261200.0 1500300.0 False True 1665862.0065691904 1205476.0137693232 1145960.0396484092 1.0 0.7236349763759707 0.6879081431291485 20.667837467816543 -13.99999999995406 0.28841043384562615 3.3602317845219365 0.6780155891719225 0.9996239047008153 0.0027046708182135977 15.871933539072321 0.17027200002272921 22.205955130031523 0.01359070916065718 1.000000000105781e-14 13.99999999995406 -2.682216195350014 KTPQGPPEIYSDTQFPSLQSTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTPQGPPEIYSDTQFPSLQSTAK 23 1 Q9UKY7;Q9UKY7-2;H0Y8K3;D6R9V8;D6RFH2;Q9UKY7-3;D6RDN0 Q9UKY7 CDV3 Protein CDV3 homolog 0 22002400.0 1970400.0 10544000.0 9488000.0 False True 2583213.481380745 8970876.300190099 8506272.775322618 1.0 3.4727583937023683 3.292903523705659 21.30073544460456 -10.30307399385298 5.351366083635694 0.9995557913203449 3.382830958704145 0.9957453144012308 0.07342544320821767 0.0003891955496655786 5.0685610973862526e-05 0.07110496662689239 0.023697959894377178 4.9765228918034756e-11 10.30307399385298 2.3832751673838004 KTPQGPPEIYSDTQFPSLQSTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTPQGPPEIYSDTQFPSLQSTAK 23 1 Q9UKY7;Q9UKY7-2;H0Y8K3;D6R9V8;D6RFH2;Q9UKY7-3;D6RDN0 Q9UKY7 CDV3 Protein CDV3 homolog 0 22458200.0 8691600.0 2783600.0 10983000.0 False True 8415689.915541304 3895105.996282237 8106222.817062616 1.0 0.46283858309573905 0.963227364412846 23.004650117401113 -10.600060739174024 9.497114802021821 1.0000456628404675 0.7130329737542926 0.30484020682409085 0.2042828645400047 0.0001975410028602715 8.318822279502139e-06 0.19782731007659116 0.06593201102324865 2.5115351508809898e-11 10.600060739174024 -0.28701268908617483 KTPQGPPEIYSDTQFPSLQSTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTPQGPPEIYSDTQFPSLQSTAK 23 1 Q9UKY7;Q9UKY7-2;H0Y8K3;D6R9V8;D6RFH2;Q9UKY7-3;D6RDN0 Q9UKY7 CDV3 Protein CDV3 homolog 0 25518400.0 1970400.0 10801000.0 12747000.0 False True 2698910.128057832 10323776.105869373 9736421.132705638 1.0 3.82516483173839 3.607538106395593 21.36394550612745 -10.25406419686897 4.353492492001338 0.9984668827562199 3.716351469041278 0.9952089789182299 0.08884573877378663 23731511.5816827 964.7422621777658 365540.67315956467 0.03251421107556205 5.571033925161114e-11 10.25406419686897 2.7178845862850585 KTPVIVTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTPVIVTLK 9 1 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 32466300.0 11284000.0 9038300.0 12144000.0 False True 14793433.27441144 7689820.871017455 10887455.37347361 1.0 0.5198131311626439 0.7359654227329302 23.81845357757853 -10.319215419318569 5.779354792829703 1.0000432689698833 0.6278892769477857 0.7980415285880312 0.08824380351342181 4.920311013517235e-05 5.795844792568612e-06 0.08545160204576449 0.028480565117789316 4.794955496286063e-11 10.319215419318569 -0.37215399202209754 KTPVIVTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTPVIVTLK 9 1 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 24356300.0 9317800.0 2606500.0 12432000.0 False True 9022011.539305858 3647289.042717939 9175686.2479944 1.0 0.40426561491613394 1.0170333088157817 23.10501770061406 -10.898865841295445 12.298623358680127 1.0165049178781145 0.7106494618659579 0.22916855522959134 0.25016136348601486 0.09822856387227633 0.0008077525131678816 0.21016062172771638 0.08073923288715634 1.2622173882596746e-11 10.898865841295445 -0.3058554560121566 KTPVIVTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTPVIVTLK 9 1 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 19676500.0 3084100.0 13310000.0 3282400.0 False True 4678805.177911569 10934726.508495335 2633632.201272974 1.0 2.3370766878940996 0.5628856302259034 22.157708726487346 -6.705043719883671 1.8125588328382898 1.826090020352244 0.5675532246873675 0.4417906512556201 0.563886744438687 0.38506419403243697 2.462751148150092 0.2478514616238152 0.6335465951025891 1.9722241847729142e-07 6.705043719883671 -1.2585367956648765 KTPVIVTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTPVIVTLK 9 1 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 38022000.0 11284000.0 11738000.0 15000000.0 False True 15455999.738634061 11219376.347624741 11457308.934697166 1.0 0.7258913391141313 0.7412855284966327 23.881663639101422 -10.626002587077435 9.856647327657903 1.0000548520009702 0.7335884338069655 0.9975020546795386 0.006284651498483134 7.576936251765047e-06 2.874967880928285e-07 0.006086331078276913 0.0020283625491952216 2.3659056038246886e-11 10.626002587077435 -0.26646641819400474 KTPVIVTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTPVIVTLK 9 1 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 16598200.0 9317800.0 4137600.0 3142800.0 False True 7748163.548529802 4115309.9275507065 3799944.94933463 1.0 0.5311335907889526 0.49043169075279286 22.885422976048336 -13.99999999999996 0.346069833269957 6.628198163056501 0.48451232723476817 0.9997471498830159 0.003676639380595852 20.274900298004802 0.1891005424800382 83.7279627259282 0.012309501207826435 1.000000000000094e-14 13.99999999999996 -6.143685835821733 KTPVIVTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTPVIVTLK 9 1 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 10988100.0 3084100.0 5151900.0 2752100.0 False True 3992428.2466997327 4865192.236115934 2251246.0389306433 1.0 1.2186048027632446 0.5638788977088303 21.928835048579796 -6.8166834940313885 1.3861900447040185 1.1182352665962905 0.5505796983591185 0.8765821701764214 0.0956133404177547 0.19782393584840352 0.7478025892467361 0.05421536525690534 0.1250799621279893 1.525163860725407e-07 6.8166834940313885 -0.567655568237172 KTSATVGPK(ub)APSGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTSATVGPKAPSGGK 15 2 P16104 P16104 H2AFX Histone H2AX 1 23265100.0 8976100.0 9830900.0 4458100.0 True False 8691158.61876874 13756429.637466252 3290389.8698667837 1.0 1.5828073379950691 0.3785904750099851 23.05111708492897 -6.775113001493825 1.554970939540008 1.3320965407911753 0.37048227685117335 0.7496962713933065 0.2460011313876132 0.2582428584063561 1.232944729706527 0.12465207614128203 0.29534343418800624 1.6783672576030853e-07 6.775113001493825 -0.961614263940002 down KTSATVGPK(ub)APSGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTSATVGPKAPSGGK 15 2 P16104 P16104 H2AFX Histone H2AX 1 25019000.0 9399300.0 12775000.0 2844700.0 True False 12874475.216531644 12210558.25872432 2172840.4484355315 1.0 0.9484315324204585 0.16877118576805883 23.618010291230696 -6.920330025407005 0.8222848732164428 1.0169994779404323 0.04208869356659368 0.9942718046309276 0.028780933716671772 0.09797831880122555 0.10461440536493087 0.02484100611275516 0.07464592095207154 1.201351166993615e-07 6.920330025407005 -0.9749107843738386 down KTTQSGQMSGEGK(ub)AGPPGGSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTTQSGQMSGEGKAGPPGGSSR 22 2 Q16630;Q16630-2 Q16630 CPSF6 Cleavage and polyadenylation specificity factor subunit 6 1 1839660.0 560900.0 674360.0 604400.0 True False 726096.1069919511 636831.2731899185 494405.4016677017 1.0 0.8770619578559149 0.6809090379452789 19.469800992222755 -6.964210953976576 0.3713494523943046 1.0148554164499988 0.5362733373119822 0.9998959373325476 0.0013404788289667045 0.07822978507991893 0.015810608681756384 0.0025802609211954893 0.016647152603817782 1.0858980319440916e-07 6.964210953976576 -0.47858207913801654 KTVLQLSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTVLQLSLR 9 1 Q99986;H0YJ50 Q99986 VRK1 Serine/threonine-protein kinase VRK1 0 6043900.0 1377100.0 2863900.0 1802900.0 False True 1805391.4358553719 2436617.2833947632 1616353.2026379786 1.0 1.349633788553076 0.8952923839877255 20.783880238205484 -6.701151141436739 1.8264971164556332 1.2168672563102343 0.8966051579214627 0.4230485070534199 0.14755492482235494 0.3931954494863439 2.5509342946335933 0.06442549083306752 0.16546676503683755 1.9899806733126527e-07 6.701151141436739 -0.3202620983887716 KTVLQLSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTVLQLSLR 9 1 Q99986;H0YJ50 Q99986 VRK1 Serine/threonine-protein kinase VRK1 0 4283230.0 1836400.0 1645800.0 801030.0 False True 1778104.4871945377 2302976.522733618 591216.2126151023 1.0 1.2951862724148535 0.3324980150901666 20.761908673428994 -6.824376349349249 1.352682125537807 1.1584369046228444 0.3094110471406987 0.8942022735881301 0.13098253306599503 0.1878403509550583 0.6741007136342909 0.07606651916622159 0.17516376470604259 1.4983858069495182e-07 6.824376349349249 -0.8490258574821457 down KTVLQLSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTVLQLSLR 9 1 Q99986;H0YJ50 Q99986 VRK1 Serine/threonine-protein kinase VRK1 0 33958800.0 8481800.0 10983000.0 14494000.0 False True 12867510.702639455 9022997.83942933 11629254.547054136 1.0 0.7012232628319076 0.9037687875922015 23.617229646727885 -10.072319287526515 4.991842419534873 1.000004621041849 0.8024960260614705 0.5590408081552956 0.08268886422814202 4.252675607556943e-06 7.901600649571011e-07 0.08006502138365253 0.026687716172178508 8.466047727216392e-11 10.072319287526515 -0.19750859498037843 KTVLQLSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTVLQLSLR 9 1 Q99986;H0YJ50 Q99986 VRK1 Serine/threonine-protein kinase VRK1 0 7421700.0 1377100.0 2694200.0 3350400.0 False True 1886251.0847281984 2575161.3354720175 2559104.5236539594 1.0 1.365227225750324 1.356714673021761 20.847090299728375 -10.08834885343924 4.56523391981221 0.9999753814289145 1.3609709493983941 0.9995830763848563 0.0034752351449231496 410699.79769068706 907572.9749108815 59.9719609458518 0.0011896655892330312 8.159267029144167e-11 10.08834885343924 0.3609955679694796 KTVLQLSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTVLQLSLR 9 1 Q99986;H0YJ50 Q99986 VRK1 Serine/threonine-protein kinase VRK1 0 31235200.0 8481800.0 13473000.0 9280400.0 False True 10979857.301273562 12723215.706281153 7591462.424945293 1.0 1.1587778745362545 0.6913990060749472 23.388355968820335 -6.815066810999157 1.393353184768397 1.0860290128443921 0.6822578609046132 0.8725895212075889 0.06926429355654862 0.19997635522897364 0.7642001100060394 0.03907881086665222 0.09019841760601004 1.5308519403492392e-07 6.815066810999157 -0.40377115193977897 KTVTAMDVVYALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KTVTAMDVVYALK 13 1 P62805 P62805 HIST1H4A Histone H4 0 11724700.0 3323700.0 6642800.0 1758200.0 False True 4357402.886756581 5651720.133431594 1576278.3298453006 1.0 1.2970386903191395 0.3617472083281696 22.05503708075352 -6.821288348230617 1.3662931325650463 1.1598953542877581 0.3407587845256171 0.8873248694859515 0.13098196622474037 0.19180915353073316 0.7032173547311809 0.07532798306055066 0.17356185745471595 1.5090778747432907e-07 6.821288348230617 -0.8191365697621411 down KTVTAMDVVYALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KTVTAMDVVYALK 13 1 P62805 P62805 HIST1H4A Histone H4 0 16434200.0 5685100.0 1049600.0 9699500.0 False True 5504629.612366408 1468710.7535916923 7158909.971237261 1.0 0.26681372899135025 1.300525280602792 22.392214062381885 -6.71622882666906 1.773304426995955 0.552143770836441 1.2985385311139588 0.494504804663485 0.308678332272584 0.3626809672817702 2.226860816328082 0.1383390965923948 0.34877768680764726 1.9220787324700062e-07 6.71622882666906 0.7463947602775178 KTVTAMDVVYALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTVTAMDVVYALK 13 1 P62805 P62805 HIST1H4A Histone H4 0 81050200.0 5023100.0 70215000.0 5812100.0 False True 7620409.937799548 57684584.65770097 4663335.88746607 1.0 7.5697482325154075 0.6119534153057183 22.86143717850244 -6.659127947898388 1.975775746327407 5.231935227561219 0.6409117615639659 0.2319126939498536 2.7978430971070605 0.48656691984722206 3.6503437496735573 1.144376773088276 3.1016530758404075 2.192159006216933e-07 6.659127947898388 -4.591023465997253 KTVTAMDVVYALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KTVTAMDVVYALK 13 1 P62805 P62805 HIST1H4A Histone H4 0 33933400.0 3323700.0 12487800.0 18121900.0 False True 4552561.709615206 11936047.704367703 13841880.452245882 1.0 2.6218310625330474 3.0404597093129424 22.118247142276413 -10.000482102150169 0.3297984513519592 7.711017575480025e-16 3.1493847544705478 0.9988382120183252 0.02999365099862587 1.3836970199230902 0.14744137349178638 1.4556281626681107 0.13262405690054566 9.988905346879573e-11 10.000482102150169 3.149384754470547 KTVTAMDVVYALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KTVTAMDVVYALK 13 1 P62805 P62805 HIST1H4A Histone H4 0 16598400.0 5685100.0 5981100.0 4932200.0 False True 4727412.542633107 5948878.627144599 5963500.216083825 1.0 1.2583794144251164 1.2614723513768555 22.172619337816162 KTVTAMDVVYALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTVTAMDVVYALK 13 1 P62805 P62805 HIST1H4A Histone H4 0 55449600.0 5023100.0 34240000.0 16186500.0 False True 6502501.970103892 32334513.90062103 13240723.087515308 1.0 4.972626544256843 2.0362505307020706 22.63256350059489 -6.568639266958287 2.311477473309075 3.7233675428054953 2.0420094434864215 0.0 1.7307432523050987 0.7340468867775628 7.360348212068581 0.6332470144351443 1.9414469934446559 2.6999811556710455e-07 6.568639266958287 -1.6813580993190738 KTVTAMDVVYALKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KTVTAMDVVYALKR 14 2 P62805 P62805 HIST1H4A Histone H4 0 44147600.0 2077600.0 27729000.0 14341000.0 False True 3151871.0929052434 22780543.302334134 11506495.064116403 1.0 7.227625315518892 3.6506870760092758 21.587777101126928 -9.055466035510001 10.228445197543902 1.000000046885132 5.439156195772 0.6725181153405717 1.460278921403624 0.0 0.0 1.4139090490470747 0.4713029952801391 8.801039385175358e-10 9.055466035510001 4.439156148886868 KTVTAMDVVYALKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KTVTAMDVVYALKR 14 2 P62805 P62805 HIST1H4A Histone H4 0 67029600.0 2077600.0 38256000.0 26696000.0 False True 2689494.155618609 36127019.97027325 21837601.924091574 1.0 13.432644906403857 8.11959448897509 21.358903423219378 -9.350875528025133 9.229315166970576 1.0000000000103493 10.776119697691794 0.8186510860169196 2.1690437500649673 0.0 0.0 2.1001675802986135 0.7000558600995377 4.457839950434323e-10 9.350875528025133 9.776119697681445 KVACIGAWHPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVACIGAWHPAR 12 1 P39023;G5E9G0;B5MCW2;H7C422;Q92901 P39023 RPL3;RPL3L 60S ribosomal protein L3;60S ribosomal protein L3-like 0 11972300.0 5595000.0 1462500.0 4914800.0 False True 7335099.182057066 1244300.7007803489 4406263.642090592 1.0 0.16963652022921868 0.6007094836384874 22.806385042856714 -10.456451632663146 7.112444046747018 1.000083713515512 0.38517300202226545 0.7306276214704379 0.17598480037702532 0.0002336414047391616 1.7855288079172704e-05 0.17041942928114537 0.05679885008715465 3.4958144028383814e-11 10.456451632663146 -0.6149107114932466 KVACIGAWHPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVACIGAWHPAR 12 1 P39023;G5E9G0;B5MCW2;H7C422;Q92901 P39023 RPL3;RPL3L 60S ribosomal protein L3;60S ribosomal protein L3-like 0 31691700.0 4027700.0 9855000.0 17809000.0 False True 5213937.047836477 9306560.586758772 14567944.735771181 1.0 1.7849391930461702 2.79403924560542 22.313941733455334 -6.967693711235955 0.3083391685097833 0.8414590697595723 3.7695187963165333 0.9999583943508792 0.004736518513615829 0.07705836515475958 0.011695060716363226 0.016087261641356775 0.08973419938855018 1.0772246648906422e-07 6.967693711235955 2.928059726556961 KVAPAPAVVK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVAPAPAVVKK 11 2 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 1612370.0 535330.0 576720.0 500320.0 True False 701822.8141430939 490675.6240369532 448551.6858083265 1.0 0.6991445905560287 0.6391238312137169 19.420747320603983 -13.999999999999998 0.2266128874784824 2.8699230199936623 0.608984559349018 0.9995053589392153 0.003511433254469597 13.188047605644625 0.15075362325501113 11.07511247047229 0.03182611182225407 1.0000000000000041e-14 13.999999999999998 -2.2609384606446445 KVAPAPAVVK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVAPAPAVVKK 11 2 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 1647690.0 535330.0 651910.0 460450.0 True False 733255.9677492881 623106.4606219153 351701.1932654201 1.0 0.8497802786856626 0.4796431379139792 19.483957382126874 -6.955771940310297 0.4914108802781712 1.0079975548723763 0.3056927514936655 0.999579836575168 0.004482215417259998 0.08124748989092095 0.026986141208175805 0.005345467136402649 0.030527909191583703 1.1072050544374364e-07 6.955771940310297 -0.7023048033787108 down KVAPAPAVVK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVAPAPAVVKK 11 2 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 1150520.0 463570.0 233680.0 453270.0 True False 600100.5033308236 220675.502578771 370779.5109429502 1.0 0.36773090732956265 0.6178623561969365 19.194844614348867 -10.30232280688226 5.707433736810609 1.0000528732223894 0.4927966317632833 0.8457348483802242 0.10211573639136953 6.870936067206682e-05 8.399084131284203e-06 0.09888339464535935 0.032957712202454546 4.985138092300099e-11 10.30232280688226 -0.5072562414591062 KVDQPPEAK(ub)KPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVDQPPEAKKPK 12 3 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 5868800.0 2564300.0 2296900.0 1007600.0 True False 2482897.700126853 3214064.148175261 743679.3326479368 1.0 1.2944811008568948 0.29952073039897764 21.243593390420052 -6.8274091568620205 1.3393593533294093 1.1576545314226268 0.2741188775794797 0.9006178792129451 0.13155700985463717 0.18402312718767902 0.6465127334302375 0.07714008702566166 0.17755893992056207 1.4879585838609841e-07 6.8274091568620205 -0.883535653843147 down KVDQPPEAK(ub)KPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVDQPPEAKKPK 12 3 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 5747560.0 2564300.0 2264800.0 918460.0 True False 2132329.0677515026 2252599.072872396 1110505.7395207705 1.0 1.0564031166388947 0.5207947292543248 21.02399866585433 -6.880881649398916 1.0749163578754808 1.0353780565601913 0.48219594987646075 0.9743876909574433 0.0384571876843536 0.12684983779805373 0.26761642811401465 0.02753846342735811 0.06674411492740669 1.3155832960161626e-07 6.880881649398916 -0.5531821066837306 KVDSSVLGSLSSVPLTGFSFSPGNSSLFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVDSSVLGSLSSVPLTGFSFSPGNSSLFGK 30 1 Q9UKX7;Q9UKX7-2 Q9UKX7 NUP50 Nuclear pore complex protein Nup50 0 127076000.0 30907000.0 35931000.0 60238000.0 False True 46888178.604361996 29518832.319815636 48331932.896746665 1.0 0.6295580932860017 1.0307914347572964 25.482720902120956 -11.938803652029085 17.696586483054038 0.8977643476186854 0.8471572876237133 0.0 0.18657599354011217 0.0 0.0 0.0 0.054295945499571924 1.1513207925345339e-12 11.938803652029085 -0.05060705999497206 KVDSSVLGSLSSVPLTGFSFSPGNSSLFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVDSSVLGSLSSVPLTGFSFSPGNSSLFGK 30 1 Q9UKX7;Q9UKX7-2 Q9UKX7 NUP50 Nuclear pore complex protein Nup50 0 57679000.0 30907000.0 14267000.0 12505000.0 False True 40009720.76805182 13473028.908299074 10229218.31213536 1.0 0.3367438874769011 0.25566832549112656 25.253847224213406 -13.999999999999998 0.2964549805326809 6.92839354571998 0.2349774962323363 0.9996419110330218 0.006309356815265515 16.361139553590803 0.1728194771338284 59.37586078622402 0.02975411799084971 1.0000000000000041e-14 13.999999999999998 -6.693416049487644 KVDWLTEK(ub)MHAR ddPTM_RPMI8226_Bortezomib_1h_R1 2 KVDWLTEKMHAR 12 2 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3QL43;J3QL52;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 53161660.0 11576500.0 20897360.0 20687800.0 True False 15176903.606985485 17779555.345271286 18547224.90739029 1.0 1.1714876634709517 1.222069098393268 23.855374146235672 -13.999999999999998 0.17114347407783884 0.13256359751637917 1.2661488725507177 0.999511539764537 0.0021003260800985576 12.102864312877523 0.1310260308700471 3.485751046088523 0.04081303340239805 1.0000000000000041e-14 13.999999999999998 1.1335852750343385 KVDWLTEK(ub)MHAR ddPTM_RPMI8226_Bortezomib_2h_R1 2 KVDWLTEKMHAR 12 2 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3QL43;J3QL52;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 65981950.0 11421950.0 16382100.0 38177900.0 True False 11059366.449309343 22923557.96152294 28177962.67755028 1.0 2.0727731616990153 2.54788217812513 23.398765405424346 -9.700653156190912 0.21737625622372922 3.5457689880719114e-20 2.9260405595948002 0.9993254012674974 0.01681576711390125 1.1373770747473753 0.09196193109396147 0.9754567577213104 0.25120492075654133 1.9922638001521746e-10 9.700653156190912 2.9260405595948002 KVDWLTEK(ub)MHAR ddPTM_RPMI8226_Bortezomib_8h_R1 2 KVDWLTEKMHAR 12 2 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3QL43;J3QL52;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 492589400.0 31380300.0 56196100.0 405013000.0 True False 47606209.30722683 46167466.89286666 324962003.0264959 1.0 0.969778261380249 6.826042395632732 25.504646421621025 -6.90573620856314 0.9242642042461285 0.7933331479517751 7.517749350064732 0.9892110658496892 0.28601313323977484 0.10730607077250466 0.15455395096829008 0.2293343159391342 0.6158523439240171 1.2424067190655533e-07 6.90573620856314 6.724416202112957 up KVDWLTEK(ub)MHAR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 KVDWLTEKMHAR 12 2 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3QL43;J3QL52;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 47685440.0 11576500.0 12656440.0 23452500.0 True False 15856644.893149363 12097236.631549818 17913502.519398984 1.0 0.7629127544362336 1.1297158156791578 23.918584207758563 -6.732186833537984 1.715090763502858 0.8576733444178869 1.1295934955165376 0.5694664129571202 0.09964972533477748 0.3321442772317645 1.9150030134853853 0.04602330309365976 0.11392928493072384 1.8527344053829865e-07 6.732186833537984 0.27192015109865075 KVDWLTEK(ub)MHAR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 KVDWLTEKMHAR 12 2 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3QL43;J3QL52;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 64811650.0 11421950.0 30910200.0 22479500.0 True False 9497857.503179938 30743680.61740567 27179859.516535465 1.0 3.236906913702644 2.8616832277632605 23.179170680858622 -10.144474330116909 4.9466490893935156 0.9998798791118823 3.049295070738914 0.9754728024451903 0.1531844283469373 10286733.57570581 21095824.73347472 9082.468707556118 0.05243910486020409 7.170107547472687e-11 10.144474330116909 2.049415191627032 KVDWLTEK(ub)MHAR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 KVDWLTEKMHAR 12 2 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3QL43;J3QL52;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 365846800.0 31380300.0 49846300.0 284620200.0 True False 40622416.94818959 47072309.586580805 232822244.04986978 1.0 1.158776683490239 5.7313735011586 25.275772743713475 -6.914267008310223 0.8661585770605559 0.8768046850328566 6.3796177868161035 0.9924349255421734 0.1908219386677383 0.10166385697640316 0.12395735611009273 0.1596023575263993 0.45476461421384184 1.2182403830520757e-07 6.914267008310223 5.5028131017832465 up KVDWLTEK(ub)MR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVDWLTEKMR 10 2 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 1 57194400.0 2293400.0 4047000.0 50854000.0 True False 2968851.5096725677 3821780.892401085 41599093.806104004 1.0 1.2872927055966454 14.011847231353089 21.501473506496403 -6.911766226338386 0.8836085938548257 0.6276882468148215 15.72002667180273 0.9915714800002159 0.5570169319368318 0.10326190464727028 0.1325131341238894 0.46005758655764306 1.2860800241595756 1.2252755677108374e-07 6.911766226338386 15.092338424987908 up KVEDLFLTFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVEDLFLTFAK 11 1 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 5836300.0 1583300.0 2251500.0 2001500.0 False True 2075721.6326990104 1915584.9762782624 1794403.9797436956 1.0 0.9228525376919032 0.8644723605883876 20.985181551530584 -6.974209628101603 0.12088470802630838 1.1036397830283589 0.6821841689194591 0.9999994192239482 4.190411570244867e-05 0.07495882186646671 0.003602310132484821 0.004070488651044499 0.008372917800282284 1.0611832147021125e-07 6.974209628101603 -0.42145561410889976 KVEDLFLTFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVEDLFLTFAK 11 1 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 4613430.0 1912700.0 625730.0 2075000.0 False True 1851982.385459049 875587.2521388415 1531495.2513343277 1.0 0.47278379050123126 0.8269491456068669 20.820638946252924 -9.955240947292722 5.600001946441517 1.0000004938339873 0.6498664680535994 0.565811805589794 0.14458740076500898 8.914215729540405e-07 1.6614378993435928e-07 0.13999634698219157 0.04666538293595801 1.1085596139240817e-10 9.955240947292722 -0.3501340257803879 KVEDLFLTFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVEDLFLTFAK 11 1 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 6855100.0 1583300.0 2323100.0 2948700.0 False True 2168688.7970736716 2220457.7605356122 2252277.790382767 1.0 1.0238710890800908 1.0385435630146136 21.048391613053475 -13.361186473382672 0.04819917213618501 0.8307965273286072 1.1302188272734006 0.999981601152708 6.788763112033814e-05 10.185689994990579 0.04727082879387772 0.25498417733586864 0.0825770732410588 4.353249177299647e-14 13.361186473382672 0.2994222999447934 KVEDMMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVEDMMK 7 1 P13639 P13639 EEF2 Elongation factor 2 0 5088800.0 1617300.0 653400.0 2818100.0 False True 1565959.6967652622 914306.0274359855 2079955.0688121784 1.0 0.5838630644994437 1.3282302687027356 20.578615651668883 -6.755029424552938 1.6315745989422408 0.7567909949509034 1.3302648075319943 0.6701932578571571 0.17492364607334487 0.29135023573715857 1.5274344804928017 0.08464693372332466 0.2043989397089154 1.75780451420876e-07 6.755029424552938 0.5734738125810909 KVEEAAK(ub)VTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVEEAAKVTGK 11 2 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 3394170.0 1096300.0 1489400.0 808470.0 True False 1061498.5565842802 2084125.1871183924 596707.4534198871 1.0 1.9633801423383455 0.5621368486265201 20.017670978805697 -6.721686919104256 1.7531493616509792 1.5850539891304378 0.5641006123013482 0.5204792255761472 0.4053133682921139 0.35206549939647286 2.115620180667371 0.18350094775394465 0.45976122083184445 1.8980737407596036e-07 6.721686919104256 -1.0209533768290897 KVEEAAK(ub)VTGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVEEAAKVTGK 11 2 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 1831380.0 637350.0 809870.0 384160.0 True False 966906.5465263559 665342.3709568093 308230.60761669086 1.0 0.6881144546461847 0.3187801434626952 19.883016931482963 -7.153829036433886 0.31209062638462715 1.0627425495836662 3.6311065079653295e-16 0.9999271864664543 0.0023759134357801324 0.08290281873608092 0.015153274586775251 0.00817163671264332 0.0369332349712256 7.01731486379468e-08 7.153829036433886 -1.0627425495836658 down KVEEAAK(ub)VTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVEEAAKVTGK 11 2 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 2709180.0 1096300.0 1167900.0 444980.0 True False 911622.0243247565 1161608.290890002 538023.2606449415 1.0 1.2742213986661979 0.5901823851211343 19.798076254239973 -6.797883424914205 1.4643763455080367 1.151706224363569 0.5812071800750269 0.8259660392924575 0.11725949613723445 0.2237808933817401 0.9475716105851508 0.06299928573147848 0.14671663362176396 1.5926361715393445e-07 6.797883424914205 -0.570499044288542 KVEEAAK(ub)VTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVEEAAKVTGK 11 2 Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q8TAQ2 SMARCC2 SWI/SNF complex subunit SMARCC2 1 1705490.0 637350.0 855310.0 212830.0 True False 825062.1390467465 807711.2466220848 174097.12382021314 1.0 0.9789701992086214 0.21101092339706684 19.654143253575413 -6.912767747809499 0.8766766123274778 1.0217479761860442 0.10565811076050255 0.9919245355432538 0.032986825200118274 0.10261680265059352 0.1290514892823711 0.02738172562502174 0.07711693535642439 1.222453229456997e-07 6.912767747809499 -0.9160898654255416 down KVEEAEPEEFVVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVEEAEPEEFVVEK 14 1 Q13185;S4R2Y4;C9JMM0;B8ZZ43 Q13185 CBX3 Chromobox protein homolog 3 0 44504600.0 16581100.0 4328500.0 23595000.0 False True 16054742.056535253 6056892.62282931 17414761.66517276 1.0 0.37726502247750454 1.0847113957887535 23.936496150405905 -6.674246212212283 1.9221225016135781 0.6039772289461631 1.0819244954833207 0.29808421619664904 0.26426715634537973 0.45143583599850845 3.2193234513254962 0.1105220445864023 0.29368317288749446 2.117160524633381e-07 6.674246212212283 0.4779472665371576 KVEEAEPEEFVVEK(ub)VLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVEEAEPEEFVVEKVLDR 18 2 Q13185;S4R2Y4;C9JMM0;B8ZZ43 Q13185 CBX3 Chromobox protein homolog 3 1 25139000.0 5530000.0 13002000.0 6607000.0 True False 7249883.552596178 11062152.281399049 5923371.0188191915 1.0 1.5258386153578565 0.8170298151475877 22.78952639211503 -6.708024137244227 1.802279782690789 1.323923831076362 0.8187919548199349 0.4557094421433143 0.22165501752300748 0.37905518517341397 2.3988745115284233 0.09791778582919204 0.24935208465331637 1.9587358077469605e-07 6.708024137244227 -0.505131876256427 KVEEAEPEEFVVEK(ub)VLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVEEAEPEEFVVEKVLDR 18 2 Q13185;S4R2Y4;C9JMM0;B8ZZ43 Q13185 CBX3 Chromobox protein homolog 3 1 41877000.0 15203000.0 10845000.0 15829000.0 True False 14720389.086701445 15175465.055927858 11682910.040178832 1.0 1.030914669887193 0.7936549755151034 23.811312469168694 -6.874121417437672 1.1120020672237376 1.0180076790413208 0.7786228256431509 0.9686290984927902 0.01865367399735416 0.13296765422430223 0.304805082464375 0.012982751335974152 0.030978479262743275 1.3362218914459035e-07 6.874121417437672 -0.23938485339816995 KVEEAEPEEFVVEK(ub)VLDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVEEAEPEEFVVEKVLDR 18 2 Q13185;S4R2Y4;C9JMM0;B8ZZ43 Q13185 CBX3 Chromobox protein homolog 3 1 27127200.0 5530000.0 12702000.0 8895200.0 True False 7574590.442630838 12140783.640103027 6794336.962394549 1.0 1.602830375062 0.8969906708295521 22.85273645363792 -6.680532335997447 1.8997470204290565 1.3812373820785648 0.8996527732251778 0.32659550967241113 0.25546477890159064 0.4373871466796436 3.0523579203196736 0.10787777825915668 0.28435246201722575 2.0867367472539302e-07 6.680532335997447 -0.48158460885338705 KVEEAEPEEFVVEK(ub)VLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVEEAEPEEFVVEKVLDR 18 2 Q13185;S4R2Y4;C9JMM0;B8ZZ43 Q13185 CBX3 Chromobox protein homolog 3 1 38665800.0 15203000.0 15650000.0 7812800.0 True False 12641968.107095921 15565690.343718223 9446420.357694272 1.0 1.2312711289772373 0.747227035985956 23.59171774460297 -6.776782040787062 1.5484153724676277 1.1314989334548697 0.7437729721626677 0.7558362867362499 0.09767707383549622 0.255606506667971 1.2102335692987871 0.049696543396728785 0.117582005898109 1.6719294944333057e-07 6.776782040787062 -0.38772596129220205 KVEEAEPEEFVVEK(ub)VLDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVEEAEPEEFVVEKVLDR 18 2 Q13185;S4R2Y4;C9JMM0;B8ZZ43 Q13185 CBX3 Chromobox protein homolog 3 1 47121200.0 15857000.0 22021000.0 9243200.0 True False 20527199.08819999 20795511.991985258 7561032.443241053 1.0 1.0130710918051895 0.36834214014066313 24.291033451071755 -6.902275838990501 0.9467920740925129 1.025157428444903 0.2974560201253737 0.9876642725282084 0.03341925309758978 0.10974868772154453 0.1681326424082189 0.02635619843145818 0.06938958257332903 1.2523455041214652e-07 6.902275838990501 -0.7277014083195292 down KVEEEEDESALK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVEEEEDESALKR 13 2 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 37016910.0 12988000.0 12148910.0 11880000.0 True False 17027393.7759709 10336339.98408028 10650771.561006792 1.0 0.6070418127445286 0.6255080314191822 24.021354296279046 -10.632657214620348 10.091924385186907 1.0000753051311806 0.6162749220866093 0.9982661024827867 0.0075388022052591906 1.2775764388005782e-05 4.650318242376449e-07 0.007300823930584024 0.0024331379492767142 2.3299295280173686e-11 10.632657214620348 -0.3838003830445713 KVEEEEDESALK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVEEEEDESALKR 13 2 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 48508000.0 15309000.0 17335000.0 15864000.0 True False 14823024.174722936 24256955.900830783 11708742.490201348 1.0 1.6364377211362255 0.7899024080502927 23.82133647870969 -6.705544639570816 1.8111079827328938 1.3930351148365037 0.7921419459634671 0.4439277909842404 0.26838568482452124 0.3840937272271064 2.4530167173422477 0.11805456126292706 0.30154320496488196 1.9699507126478368e-07 6.705544639570816 -0.6008931688730366 KVEEEEDESALK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVEEEEDESALKR 13 2 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 115445000.0 28746000.0 41638000.0 45061000.0 True False 43609783.6141 34207373.58082116 36154673.599062085 1.0 0.7843967739789739 0.8290495985715574 25.37814849618943 -10.60123217254826 6.4595731787846455 1.0005132273531623 0.8067231862752658 0.9615095263088516 0.01822943930430494 0.00013508751688583672 8.339322590611405e-06 0.01769641990909215 0.005883526236355986 2.5047698524736028e-11 10.60123217254826 -0.19379004107789644 KVEEEEDESALK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVEEEEDESALKR 13 2 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 39973000.0 12988000.0 10461000.0 16524000.0 True False 17790014.587502573 9998798.430099024 12621371.522462381 1.0 0.5620455441966387 0.7094638096209799 24.084564357801938 -10.381841039473482 5.294423028222877 1.0001943564457605 0.6357546769087988 0.8905907428438357 0.06018325484267179 0.00013814156561295932 1.6128841860833038e-05 0.058302948991284846 0.01942406197718012 4.151059519698587e-11 10.381841039473482 -0.36443967953696166 KVEEEEDESALK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVEEEEDESALKR 13 2 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 50403000.0 15309000.0 24085000.0 11009000.0 True False 12730111.80369215 23955249.324501798 13310931.000135211 1.0 1.8817783923589726 1.0456256162867794 23.601741754143966 -10.178730253597136 3.831964543854062 0.9996973161157753 1.4637020032117776 0.2908093668724462 0.3413579426235919 241359899.17268097 541386186.0976249 1041322.8692005638 0.12492421157689201 6.626279434360577e-11 10.178730253597136 0.4640046870960023 KVEEEEDESALK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVEEEEDESALKR 13 2 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 97514000.0 28746000.0 32575000.0 36193000.0 True False 37212263.66837339 30762172.614273652 29606245.37154056 1.0 0.8266675977688062 0.7956045253087582 25.149274818281878 -13.999999999077563 0.24180971978252158 2.1574379026498955 0.7821039738427567 0.999527995831472 0.001953778486380842 13.687956660561793 0.15562807533094625 7.658305482861029 0.015018810316161516 1.0000000021239902e-14 13.999999999077563 -1.375333928807139 KVEEVTK(ub)VCEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVEEVTKVCEGR 12 2 P37198;M0QXN5 P37198 NUP62 Nuclear pore glycoprotein p62 1 7961200.0 2833900.0 2164800.0 2962500.0 True False 2743939.3956984314 3029215.929282867 2186532.3769050348 1.0 1.1039660475124387 0.7968588447444495 21.387817186953384 -6.815360322647067 1.3917200817597328 1.0563134861611334 0.790792797052084 0.8734044087946174 0.04537784731868327 0.19957778302605664 0.7607625352865383 0.025629525531133197 0.05916040861909126 1.529817685726052e-07 6.815360322647067 -0.26552068910904936 KVEEVTK(ub)VCEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVEEVTKVCEGR 12 2 P37198;M0QXN5 P37198 NUP62 Nuclear pore glycoprotein p62 1 10770400.0 2833900.0 2330700.0 5605800.0 True False 2356513.413056578 2318144.0564922728 6777946.861709319 1.0 0.9837177431913968 2.8762606756894304 21.16822246238766 -6.904960862219534 0.9293889800815125 0.9316623329833705 3.096192051404327 0.9888764496484427 0.09369170122655926 0.10784474755245431 0.1575483598380933 0.07484459671283068 0.2000523242121066 1.244626770079797e-07 6.904960862219534 2.1645297184209564 up KVEGNFNPFASPQK(ub)NR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVEGNFNPFASPQKNR 16 2 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 35389100.0 13155800.0 13210700.0 9022600.0 True False 17247381.200948425 11239715.054905266 8089027.90289058 1.0 0.6516766182617452 0.4690003548159397 24.039873987538805 -12.726561585974256 0.09227457362055289 2.4426318039373567 3.272357909351106e-11 0.999868125121885 0.002529476000419616 7.6905387773147575 0.07585065352522502 2.463325414839674 0.37569655804614727 1.87688824371245e-13 12.726561585974256 -2.442631803904633 KVEGNFNPFASPQK(ub)NR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVEGNFNPFASPQKNR 16 2 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 54499800.0 15684300.0 20910900.0 17904600.0 True False 15186410.48165177 29260731.418902945 13214848.13351355 1.0 1.9267707437683037 0.8701758818833283 23.856277573400675 -6.675019142913162 1.9197158365578981 1.5889803044852293 0.8743500387985296 0.3014524181626389 0.39322205690228235 0.4496672106362529 3.1994863714921364 0.16463105393993618 0.43697279439502446 2.1133958831257228e-07 6.675019142913162 -0.7146302656866997 KVEGNFNPFASPQK(ub)NR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVEGNFNPFASPQKNR 16 2 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 44555600.0 17403400.0 12183000.0 14969200.0 True False 26402230.158965684 10008848.463786544 12010531.05876656 1.0 0.3790910238841219 0.4549059297813907 24.65415646134792 -10.536113337468834 6.306813104733186 1.000691867940726 0.41699847683398245 0.9874755845105498 0.030951305724238657 0.00030142902412323437 2.217102817463763e-05 0.030000995363247882 0.009989490967779213 2.9099576097556546e-11 10.536113337468834 -0.5836933911067435 KVEGNFNPFASPQK(ub)NR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVEGNFNPFASPQKNR 16 2 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 42242600.0 13155800.0 16471300.0 12615500.0 True False 18019854.782127082 15743543.502694795 9635978.724378131 1.0 0.8736776013483728 0.5347423073539714 24.103084049061696 -6.953930164717811 0.5138930230800842 1.006043470816335 0.38740788444038005 0.9994746882285878 0.0045023458012179406 0.08194499549171352 0.029720740071075485 0.005151641857295103 0.027981051059046396 1.1119105099846463e-07 6.953930164717811 -0.618635586375955 KVEGNFNPFASPQK(ub)NR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVEGNFNPFASPQKNR 16 2 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 49156800.0 15684300.0 26241000.0 7231500.0 True False 13042190.382301182 26099634.524569344 8743573.21532179 1.0 2.001169570411093 0.6704068073708844 23.63668284883495 -6.705401170501845 1.8114591152011363 1.6183588714331232 0.6739167079107172 0.4433204977236157 0.4222026384174199 0.38438531972855355 2.455700503087331 0.1856778531434005 0.4743829007613162 1.9706015928557574e-07 6.705401170501845 -0.944442163522406 KVEHEISEGNVATAAAAALASAATK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVEHEISEGNVATAAAAALASAATKAK 27 2 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 8588500.0 1782800.0 3218700.0 3587000.0 True False 2337268.0646597594 2738482.50639433 3215851.648933617 1.0 1.1716595746123695 1.375901933354724 21.15639177771825 -6.968821521972833 0.2849425739293454 0.9575996916189079 1.5962278152406815 0.9999716687557774 0.0008178319695212825 0.07668707893529238 0.0103929746253599 0.003668385592702433 0.018632734477938714 1.0744308706422519e-07 6.968821521972833 0.6386281236217736 KVEHEISEGNVATAAAAALASAATK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVEHEISEGNVATAAAAALASAATKAK 27 2 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 25887400.0 11962800.0 7628500.0 6296100.0 True False 11583047.462105647 10674599.832101956 4646962.531048706 1.0 0.9215709308819022 0.4011865224804966 23.465511535850972 -6.933744892442673 0.7153845578090546 1.0069204397319116 0.2833973170212383 0.9972244315180935 0.013999813260072757 0.09073943347809092 0.06849237318902537 0.013051550503908823 0.04615468408488187 1.1648100459027775e-07 6.933744892442673 -0.7235231227106733 down KVEHEISEGNVATAAAAALASAATK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVEHEISEGNVATAAAAALASAATKAK 27 2 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 19470300.0 1782800.0 14557000.0 3130500.0 True False 2441949.338358456 13913823.60643836 2391140.374671298 1.0 5.697834671620012 0.9791932769083109 21.219601839241143 -6.647146318643299 2.018587800075821 4.05515507788735 0.9988575518179863 0.18275042206219327 2.0064700770710084 0.5154462783079584 4.022388441846906 0.8070312757364142 2.2223665035849134 2.253479861803165e-07 6.647146318643299 -3.056297526069364 KVEHEISEGNVATAAAAALASAATK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVEHEISEGNVATAAAAALASAATKAK 27 2 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 33794600.0 11962800.0 14486100.0 7345700.0 True False 9947598.241897466 14408060.50403427 8881651.907320658 1.0 1.4483958995599713 0.8928438494744152 23.245916811285248 -6.69191912705644 1.8594740822671363 1.280609242000831 0.8947131532805915 0.37944508360315277 0.18956688680954503 0.4125758938761565 2.7672504726579676 0.08150847441467238 0.2117512900215663 2.0327355052648122e-07 6.69191912705644 -0.3858960887202395 KVEK(ub)IDDFKAEDFQIEGYNPHPTIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVEKIDDFKAEDFQIEGYNPHPTIK 25 3 P04818;P04818-2;P04818-3 P04818 TYMS Thymidylate synthase 1 58456400.0 26457000.0 9937400.0 22062000.0 True False 34249108.045437805 9384374.95432334 18046942.3752363 1.0 0.27400348475858766 0.5269317481580448 25.029563080454633 -10.266929308268743 5.572827622115783 1.0000492647231434 0.400467616459147 0.8822353006872352 0.10325753114287899 6.320773102963908e-05 8.314603835510299e-06 0.09998684902871872 0.03332622487389705 5.408423507060053e-11 10.266929308268743 -0.5995816482639964 KVEMMNEK(ub)NLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVEMMNEKNLEK 12 2 Q969S3 Q969S3 ZNF622 Zinc finger protein 622 1 2367140.0 686510.0 1312900.0 367730.0 True False 940331.2992351715 1254891.736820285 280879.74763707904 1.0 1.3345208628501088 0.2987029655032599 19.84280961373263 -6.819761382895102 1.372834174353472 1.1803472084008217 0.27619105224993007 0.8838568871402241 0.14709416534050218 0.193785722851076 0.7176965646931626 0.08419876298344652 0.19408389162431341 1.514393082258746e-07 6.819761382895102 -0.9041561561508917 down KVENEDMNK(ub)DQILLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVENEDMNKDQILLEK 16 2 Q15019;Q15019-2;Q15019-3;B5MCX3 Q15019 SEPT2 Septin-2 1 32092900.0 6914900.0 11038000.0 14140000.0 True False 9065500.86398686 9391173.42578701 12676928.440457594 1.0 1.0359243870456072 1.3983704409336395 23.11195529961111 -6.926049479439963 0.7785195915321595 0.993607463806445 1.4658118895271544 0.9957036639651913 0.011793435278736884 0.09474095715061474 0.08810874524159623 0.010501959017078214 0.03353544161011069 1.1856336604929318e-07 6.926049479439963 0.4722044257207093 KVENEDMNK(ub)DQILLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVENEDMNKDQILLEK 16 2 Q15019;Q15019-2;Q15019-3;B5MCX3 Q15019 SEPT2 Septin-2 1 44988200.0 9029200.0 12119000.0 23840000.0 True False 8742572.988334207 16958179.89975009 17595588.815330327 1.0 1.9397241432674925 2.0126327614089448 23.059626504796007 -10.988464743957904 0.45775617821014075 6.718526742371806e-10 2.012706965147771 0.9996836317225962 0.008202115891652866 2.780594074059044 0.22247557268476584 2.9523330785842186 0.016144909301601094 1.0269167934276397e-11 10.988464743957904 2.0127069644759183 KVENEDMNK(ub)DQILLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVENEDMNKDQILLEK 16 2 Q15019;Q15019-2;Q15019-3;B5MCX3 Q15019 SEPT2 Septin-2 1 104113000.0 20210000.0 53073000.0 30830000.0 True False 30660047.548909824 43601708.48875832 24736436.986730948 1.0 1.4221017896075852 0.8067970849448503 24.869856598602983 -6.722084904375951 1.7517034341173001 1.2562362305213859 0.8076385039099466 0.5222827034130222 0.17757955721181318 0.3513359079019552 2.107960276244796 0.08045631481168103 0.2014902313763893 1.8963351523000783e-07 6.722084904375951 -0.44859772661143926 KVENEDMNK(ub)DQILLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVENEDMNKDQILLEK 16 2 Q15019;Q15019-2;Q15019-3;B5MCX3 Q15019 SEPT2 Septin-2 1 34878900.0 6914900.0 13902000.0 14062000.0 True False 9471525.398146112 13287763.672233704 10740845.215980776 1.0 1.4029169657122553 1.134014297008918 23.175165361134002 -10.384260734226293 5.157972475588139 0.9998209713607511 1.2684656313606024 0.5706316918974756 0.1097790547993632 0.0002261570870939912 2.6997756533547995e-05 0.10636350965261349 0.03543103758335252 4.1279959808258366e-11 10.384260734226293 0.2686446599998513 KVENEDMNK(ub)DQILLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVENEDMNKDQILLEK 16 2 Q15019;Q15019-2;Q15019-3;B5MCX3 Q15019 SEPT2 Septin-2 1 39582200.0 9029200.0 21808000.0 8745000.0 True False 7508179.861382011 21690515.975450933 10573539.067688465 1.0 2.888918003551718 1.4082692826890033 22.840031780230284 -6.585023160933996 2.247904346382378 2.2824127420384595 1.412283033721141 0.0 0.8195689790952235 0.6843031295551089 6.511335926252462 0.3052505331094336 0.9146647288777832 2.600020900297709e-07 6.585023160933996 -0.8701297083173185 KVENEDMNK(ub)DQILLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVENEDMNKDQILLEK 16 2 Q15019;Q15019-2;Q15019-3;B5MCX3 Q15019 SEPT2 Septin-2 1 109683000.0 20210000.0 56255000.0 33218000.0 True False 26162243.398658145 53124359.79788068 27172664.845462784 1.0 2.0305735631450252 1.038621360997523 24.640982920695432 -6.637237694325996 2.0541636162486525 1.6753382373098593 1.0427031736250476 0.14416153079410554 0.44125650981682096 0.5404027143355233 4.354523128474484 0.17512648394213465 0.48870552729212313 2.3054850250895e-07 6.637237694325996 -0.6326350636848117 KVENEDMNKDQILLEK(ub)EAELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVENEDMNKDQILLEKEAELR 21 3 Q15019;Q15019-2;Q15019-3;B5MCX3 Q15019 SEPT2 Septin-2 1 10483600.0 2464000.0 3600700.0 4418900.0 True False 2385781.6687254077 5038478.287402438 3261457.525841571 1.0 2.1118773580376367 1.3670393936692409 21.18603059229889 -10.173012315801014 4.880094804410741 0.9999319024622582 1.7394583758556088 0.5678745678825992 0.3040788256334867 213195254.61327636 21.654892223922676 163139.06678842896 0.10409427003582798 6.714098126957775e-11 10.173012315801014 0.7395264733933506 KVEPWK(ub)EQFFESYYGQSSGLSLEDSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVEPWKEQFFESYYGQSSGLSLEDSK 26 2 A0A5F9ZHN2;E7EWD6;Q76L83-2;Q76L83 A0A5F9ZHN2 ASXL2 Putative Polycomb group protein ASXL2 1 101428100.0 44639400.0 10036000.0 46752700.0 True False 43222346.68137217 14043427.137048604 34506765.319064304 1.0 0.3249112603851515 0.79835473935375 25.365274067127846 -10.382596466652014 9.901987285667232 1.0000003375327338 0.5616329998694508 0.5333827433944436 0.19328249092019423 1.4403242311618647e-06 8.983948530853311e-08 0.1871451121120109 0.06238165570394988 4.143845296144754e-11 10.382596466652014 -0.43836733766328295 KVEPWK(ub)EQFFESYYGQSSGLSLEDSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVEPWKEQFFESYYGQSSGLSLEDSK 26 2 A0A5F9ZHN2;E7EWD6;Q76L83-2;Q76L83 A0A5F9ZHN2 ASXL2 Putative Polycomb group protein ASXL2 1 415127000.0 135156000.0 141671000.0 138300000.0 True False 205041533.22713757 116388703.16942471 110964944.38095671 1.0 0.5676347681252146 0.5411827673861265 27.61134093083809 -13.999999999999998 0.3974567467672975 8.170237375535287 0.5395364189405139 0.9998341407478614 0.002708771793195195 26.39892455831066 0.2074868104358903 163.08451550428074 0.006816452391529538 1.0000000000000041e-14 13.999999999999998 -7.630700956594772 KVEPWK(ub)EQFFESYYGQSSGLSLEDSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVEPWKEQFFESYYGQSSGLSLEDSK 26 2 A0A5F9ZHN2;E7EWD6;Q76L83-2;Q76L83 A0A5F9ZHN2 ASXL2 Putative Polycomb group protein ASXL2 1 87338300.0 44639400.0 31667900.0 11031000.0 True False 37119638.960724734 31497298.73711398 13337531.098418687 1.0 0.84853461992021 0.3593119834093958 25.145679342562122 -6.949779735877542 0.5612573513177052 1.0063567654386143 0.17805862023884708 0.999183878692535 0.007810639790525255 0.08357432698721204 0.03632945269054509 0.008359902192919043 0.04067885439573571 1.1225876604583093e-07 6.949779735877542 -0.8282981451997672 down KVEPWK(ub)EQFFESYYGQSSGLSLEDSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVEPWKEQFFESYYGQSSGLSLEDSK 26 2 A0A5F9ZHN2;E7EWD6;Q76L83-2;Q76L83 A0A5F9ZHN2 ASXL2 Putative Polycomb group protein ASXL2 1 370803000.0 135156000.0 127207000.0 108440000.0 True False 174962106.32305962 120127818.62606019 88705032.68836118 1.0 0.68659334955793 0.5069956835371617 27.38246725293054 -10.857658531996888 0.09418160477210238 1.9692402843856187 9.307919488477962e-10 0.9999175862544915 0.0018494412504490689 3.0524558501283807 0.055393991585822026 0.9658203937666611 0.31766601921610543 1.3878466070695173e-11 10.857658531996888 -1.9692402834548268 KVEPWK(ub)EQFFESYYGQSSGLSLEDSKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVEPWKEQFFESYYGQSSGLSLEDSKK 27 3 A0A5F9ZHN2;E7EWD6;Q76L83-2;Q76L83 A0A5F9ZHN2 ASXL2 Putative Polycomb group protein ASXL2 1 88912600.0 17080000.0 21787600.0 50045000.0 True False 16537804.74911933 30487502.30083301 36936713.18218141 1.0 1.8435035824483614 2.2334713550266314 23.979264406111845 -9.902794962287805 0.1902083369583331 1.2321576720983903e-12 2.622664040341605 0.9994942197799775 0.01157726718077394 1.4029094522139975 0.08532525172710016 0.9830075904166574 0.248665535388507 1.2508494378444416e-10 9.902794962287805 2.6226640403403727 KVEPWK(ub)EQFFESYYGQSSGLSLEDSKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVEPWKEQFFESYYGQSSGLSLEDSKK 27 3 A0A5F9ZHN2;E7EWD6;Q76L83-2;Q76L83 A0A5F9ZHN2 ASXL2 Putative Polycomb group protein ASXL2 1 481694000.0 132701000.0 171016000.0 177977000.0 True False 201317118.7425966 140496858.64589325 142799767.9399096 1.0 0.6978882845304977 0.7093274969948925 27.58489461429395 -9.919262597638781 5.4731948949075 1.0000003603961878 0.7036078907664838 0.9988840724640566 0.00467003893662907 2.0541384435207542e-08 4.0502543597534395e-09 0.004521751280287382 0.0015072485850932224 1.2043075315227108e-10 9.919262597638781 -0.296392469629704 KVEPWK(ub)EQFFESYYGQSSGLSLEDSKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVEPWKEQFFESYYGQSSGLSLEDSKK 27 3 A0A5F9ZHN2;E7EWD6;Q76L83-2;Q76L83 A0A5F9ZHN2 ASXL2 Putative Polycomb group protein ASXL2 1 63599100.0 17080000.0 32827000.0 13692100.0 True False 14202776.77229486 32650154.43535063 16555054.804882495 1.0 2.2988571149721078 1.1656209958306314 23.75966968154612 -6.613166857690396 2.1420585460019375 1.8659066312342605 1.1697684419944725 0.06037729513917245 0.5595267622271678 0.6039031798445396 5.2554825789792465 0.21536307984168093 0.6208720697512587 2.436874381529524e-07 6.613166857690396 -0.696138189239788 KVEPWK(ub)EQFFESYYGQSSGLSLEDSKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVEPWKEQFFESYYGQSSGLSLEDSKK 27 3 A0A5F9ZHN2;E7EWD6;Q76L83-2;Q76L83 A0A5F9ZHN2 ASXL2 Putative Polycomb group protein ASXL2 1 420573000.0 132701000.0 153522000.0 134350000.0 True False 171784060.42777485 144978365.7433159 109899678.54741162 1.0 0.8439570317658828 0.6397548077146424 27.3560209363864 -6.967425943402722 0.3136371237591388 1.0301379584186527 0.4470485135841665 0.9999547742462425 0.0009919684755840656 0.07714710215677036 0.01200546975037783 0.0031791864406335835 0.018066514576285664 1.0778890414062004e-07 6.967425943402722 -0.5830894448344863 KVESLWPIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVESLWPIFR 10 1 P41223-2;P41223 P41223-2 BUD31 Protein BUD31 homolog 0 5811260.0 514230.0 885340.0 4411690.0 False True 674160.509810403 753250.7230282899 3955210.638718695 1.0 1.1173165916231578 5.866867876658981 19.3627325957232 -6.912211415861127 0.8805494534009416 0.8630298657544864 6.51059260624004 0.9917294902815886 0.20617699396896585 0.10297352087109757 0.1309727086401983 0.1706677535035118 0.4786552540410913 1.2240201974923397e-07 6.912211415861127 5.647562740485554 up KVESLWPIFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVESLWPIFR 10 1 P41223-2;P41223 P41223-2 BUD31 Protein BUD31 homolog 0 6391250.0 514230.0 776850.0 5100170.0 False True 704354.7275432281 742526.1983005855 3895614.8872982915 1.0 1.054193532412991 5.530757067374418 19.425942657246093 -6.9095425407643045 0.8988443753892211 0.8593834679950262 6.103652642251611 0.9907477922502449 0.2042234633498392 0.10472130298284515 0.1404138404418114 0.1668232123457278 0.4590610596357949 1.2315653434089728e-07 6.9095425407643045 5.244269174256585 up KVFLSIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVFLSIK 7 1 B5MCF9;O00541-2;O00541;B3KXD6;H7BYY8 B5MCF9 PES1 Pescadillo homolog 0 14368400.0 3429200.0 4681100.0 6258100.0 False True 4495714.408420034 3982698.126784887 5610571.8439340675 1.0 0.8858877065957933 1.247982263603314 22.100118960167098 -6.821981256076267 1.3632751312077147 0.9386145454056057 1.2562286050146123 0.8888823596765096 0.05038633066614479 0.19091800771126208 0.6966638373876081 0.02903986201833401 0.06689961581886773 1.5066720919665662e-07 6.821981256076267 0.31761405960900657 KVFLSIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVFLSIK 7 1 B5MCF9;O00541-2;O00541;B3KXD6;H7BYY8 B5MCF9 PES1 Pescadillo homolog 0 6484100.0 2462900.0 1033700.0 2987500.0 False True 2384716.587623301 1446461.800674288 2204984.1269211113 1.0 0.6065550129442789 0.9246315215673835 21.185386388206524 -9.924561437052294 6.542823583381245 1.0000000215558569 0.7655932672558244 0.41999686485832066 0.12985419088212108 4.0775963154786747e-08 6.872390490580445e-09 0.1257307909216077 0.0419102598934709 1.1897030170591582e-10 9.924561437052294 -0.23440675430003244 KVFLSIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVFLSIK 7 1 B5MCF9;O00541-2;O00541;B3KXD6;H7BYY8 B5MCF9 PES1 Pescadillo homolog 0 13771300.0 3806200.0 4391800.0 5573300.0 False True 5774283.670492843 3608048.9767099847 4471734.8121358305 1.0 0.6248478915484305 0.774422433554284 22.461210553233467 -10.079228036383027 5.051269520891925 1.0000067078250707 0.6996351637670408 0.8431808227745287 0.06106355107465834 4.612956588306786e-06 8.40811696279533e-07 0.05912584895653287 0.019708176363817637 8.332435558956796e-11 10.079228036383027 -0.3003715440580299 KVFLSIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVFLSIK 7 1 B5MCF9;O00541-2;O00541;B3KXD6;H7BYY8 B5MCF9 PES1 Pescadillo homolog 0 14608800.0 3429200.0 3650600.0 7529000.0 False True 4697067.9106455045 3489304.421080152 5750805.264622333 1.0 0.7428686336793089 1.2243393908758744 22.16332902168999 -6.761622032623542 1.6062472859349637 0.850943930059523 1.22624743162987 0.6975785321039079 0.10817729009915823 0.2802115231295471 1.4252075133434792 0.0531273602830101 0.12747575813509968 1.7313224772266192e-07 6.761622032623542 0.375303501570347 KVFLSIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVFLSIK 7 1 B5MCF9;O00541-2;O00541;B3KXD6;H7BYY8 B5MCF9 PES1 Pescadillo homolog 0 6010900.0 2462900.0 1626900.0 1921100.0 False True 2048010.4749698474 1618135.5667856338 2322793.1278372006 1.0 0.7901012160640719 1.1341705309741636 20.9657916636408 -6.741580001556836 1.6807652945328426 0.8753426002342832 1.1344489458436877 0.6120982256937824 0.08818801274661776 0.31495434047391385 1.7475717540135614 0.04149689230354066 0.10165932585875308 1.8130926545976766e-07 6.741580001556836 0.2591063456094045 KVFLSIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVFLSIK 7 1 B5MCF9;O00541-2;O00541;B3KXD6;H7BYY8 B5MCF9 PES1 Pescadillo homolog 0 16982500.0 3806200.0 8143900.0 5032400.0 False True 4927200.931418725 7690684.805936547 4116554.8367844764 1.0 1.5608628332764403 0.8354753325635467 22.232336875325917 -6.70025008656689 1.8298573505923295 1.348189934266188 0.8376174108389624 0.4187758407525429 0.2367369399669982 0.39502691538558915 2.5716648414881007 0.10320253430240339 0.2653396566611866 1.994113682691367e-07 6.70025008656689 -0.5105725234272257 KVGDDIAK(ub)ATGDWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVGDDIAKATGDWK 14 2 P30050 P30050 RPL12 60S ribosomal protein L12 1 8321200.0 2494800.0 4553100.0 1273300.0 True False 3270706.9596775644 3873795.227844792 1141551.1303560573 1.0 1.1843907985650544 0.34902274781247744 21.641171075685122 -6.848816153375294 1.240689672040595 1.0983126275667092 0.3163651163469479 0.9385757041681908 0.08880853288231055 0.1587669628264064 0.47087276182159116 0.0560259230187749 0.1295609532205621 1.4163932441902765e-07 6.848816153375294 -0.7819475112197614 down KVGDDIAK(ub)ATGDWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVGDDIAKATGDWK 14 2 P30050 P30050 RPL12 60S ribosomal protein L12 1 10871000.0 3987100.0 4971800.0 1912100.0 True False 3860531.6929281964 6957065.6675944915 1411263.648229574 1.0 1.8021003895237 0.3655619900271138 21.88036812612474 -6.755145136920776 1.6304678306707254 1.4686977768068932 0.361486368777352 0.6709545571350439 0.3371734009776068 0.29114780309996136 1.5242190636402277 0.16324671574232502 0.3942543953752121 1.7573362314265664e-07 6.755145136920776 -1.1072114080295412 KVGDDIAK(ub)ATGDWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVGDDIAKATGDWK 14 2 P30050 P30050 RPL12 60S ribosomal protein L12 1 8983400.0 2494800.0 3519100.0 2969500.0 True False 3417194.9794349726 3363614.5258925064 2268165.2587722135 1.0 0.9843203405527285 0.6637506119557892 21.704381137208014 -6.917078551585043 0.8461071425217909 1.0078449786041204 0.6153761592738498 0.993330246893432 0.01265421739083589 0.09992146561256572 0.1147453742777597 0.01073747838980982 0.03131814393969434 1.2103791903983654e-07 6.917078551585043 -0.39246881933027056 KVGDDIAK(ub)ATGDWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVGDDIAKATGDWK 14 2 P30050 P30050 RPL12 60S ribosomal protein L12 1 9778500.0 3987100.0 4897000.0 894400.0 True False 3315450.308478733 4870618.889021599 1081414.904761642 1.0 1.4690670756143656 0.32617436672059197 21.660773401559016 -6.795282543891272 1.4752630010768657 1.2603777415454684 0.31220661455150645 0.8179410780180084 0.20014593989920143 0.22757538686786485 0.9782754963998247 0.10675859412714911 0.24901011014789437 1.6022026883540489e-07 6.795282543891272 -0.948171126993962 down KVGDDIAK(ub)ATGDWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVGDDIAKATGDWK 14 2 P30050 P30050 RPL12 60S ribosomal protein L12 1 29308000.0 12774000.0 8859700.0 7674300.0 True False 16536194.81318449 8366649.906697778 6277656.14496764 1.0 0.5059598052163099 0.37963124019090505 23.979123954601782 -13.999999999698842 0.1914823542289761 3.6620560164363307 0.29034126977286967 0.9994886607594405 0.006053082733081651 12.375210481673125 0.1387686178894551 12.297789681624204 0.08586452686633902 1.0000000006934423e-14 13.999999999698842 -3.371714746663461 KVGLIAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVGLIAAR 8 1 P62917;E9PKU4;E9PP36 P62917 RPL8 60S ribosomal protein L8 0 12613500.0 3678900.0 4228200.0 4706400.0 False True 4823073.526518275 3597369.04139451 4219426.874976639 1.0 0.7458665147059061 0.8748419139325453 22.20152137310732 -10.17512363269225 4.892383624959313 1.000017471549036 0.8103542143187141 0.7424525117643019 0.05265398624793719 1.0035173335744866e-05 1.6920134470662014e-06 0.050986698095017 0.01699400098722258 6.681536839800771e-11 10.17512363269225 -0.18966325723032185 KVGLIAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVGLIAAR 8 1 P62917;E9PKU4;E9PP36 P62917 RPL8 60S ribosomal protein L8 0 7605300.0 2657600.0 1274700.0 3673000.0 False True 2573235.942696691 1783694.3574726835 2710931.112361922 1.0 0.6931717095492664 1.0535105107854703 21.295152314679004 -6.681147871228836 1.8976320706728915 0.8060668146474772 1.0521566682720518 0.3294269649341873 0.13000862411109168 0.4360000123121175 3.0364525511258944 0.05495165232052359 0.14472789691378346 2.0837812637673084e-07 6.681147871228836 0.24608985362457458 KVGLIAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVGLIAAR 8 1 P62917;E9PKU4;E9PP36 P62917 RPL8 60S ribosomal protein L8 0 21411100.0 2437800.0 16609000.0 2364300.0 False True 3698320.8270525616 13644994.183290705 1896995.0686904984 1.0 3.6895106783273075 0.5129341550939323 21.818438952400765 -6.682332180549063 1.8936036501637559 2.6981373984461805 0.524822669094352 0.33477747634992727 1.1393077042105384 0.4333951687285621 3.006559587574624 0.48242420695020644 1.2685714088048405 2.078106589410187e-07 6.682332180549063 -2.1733147293518282 KVGLIAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVGLIAAR 8 1 P62917;E9PKU4;E9PP36 P62917 RPL8 60S ribosomal protein L8 0 10354000.0 3678900.0 3719000.0 2956100.0 False True 5039088.74853428 3554682.2829116043 2257930.0627905517 1.0 0.7054216467105396 0.44808301172455356 22.26473143463021 -7.093819205501728 0.19220019616437364 1.1774704840583687 2.068175567507537e-12 0.9999947388248507 0.0005171800218280388 0.07588251507231633 0.006833892503637568 0.010444395792274653 0.0294406248931713 8.057137857852607e-08 7.093819205501728 -1.1774704840563006 down KVGLIAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVGLIAAR 8 1 P62917;E9PKU4;E9PP36 P62917 RPL8 60S ribosomal protein L8 0 5819400.0 2657600.0 1971000.0 1190800.0 False True 2209912.151642317 1960381.831787134 1439790.7743628835 1.0 0.8870858646260024 0.6515149361448099 21.07555759011328 -6.959210293489603 0.4464234616539143 1.0078805912604047 0.5214369780983756 0.9997397800283735 0.0023418784594634546 0.07998442968474496 0.022182746423908495 0.003132395759583428 0.019496457913413187 1.0984738091237637e-07 6.959210293489603 -0.4864436131620291 KVGLIAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVGLIAAR 8 1 P62917;E9PKU4;E9PP36 P62917 RPL8 60S ribosomal protein L8 0 7947700.0 2437800.0 2302900.0 3207000.0 False True 3155780.156222105 2174741.590588203 2623358.906598803 1.0 0.6891296233992619 0.8312869644694508 21.589565274493214 -10.185277504496796 5.113593568203795 1.0000163558973936 0.7602082939341682 0.7913949527120652 0.058035491469447836 1.0822455576456243e-05 1.7243267277133746e-06 0.056196453547158756 0.01873087432908381 6.527133500834389e-11 10.185277504496796 -0.23980806196322535 KVHVIFNYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVHVIFNYK 9 1 P27797;K7EJB9 P27797 CALR Calreticulin 0 1372700100.0 503037000.0 398119200.0 471543900.0 False True 659486378.4172375 338721367.2164872 422753060.59648424 1.0 0.5136138945423194 0.6410338021098911 29.29676762025449 -10.236931336400804 8.186539751237603 1.0000002393953977 0.577323848326126 0.9361906046700214 0.05201895943552459 2.273159148948105e-07 2.1223573822221517e-08 0.05036716903901476 0.016789046965068832 5.795203135363062e-11 10.236931336400804 -0.4226763910692717 KVHVIFNYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVHVIFNYK 9 1 P27797;K7EJB9 P27797 CALR Calreticulin 0 1359569900.0 409203800.0 215726700.0 734639400.0 False True 396213849.3558355 301867496.3098786 542215302.4304104 1.0 0.7618802240271378 1.3684915439274625 28.561704068523117 -6.800228455406452 1.454932608736328 0.8686530072023669 1.3769162195776317 0.8328243882512771 0.10203265735390961 0.2204432722251834 0.9212331189512611 0.05516850303459363 0.12828648413744279 1.5840596976390433e-07 6.800228455406452 0.5082632123752647 KVHVIFNYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVHVIFNYK 9 1 P27797;K7EJB9 P27797 CALR Calreticulin 0 2782509900.0 736582000.0 716674000.0 1329253900.0 False True 1117448745.3573031 588777925.3004798 1066526284.0323192 1.0 0.5268947929349713 0.9544297118444555 30.05756151401709 -10.3796019455843 8.584207563074083 1.0000012252933141 0.7406622523897135 0.32912894455435027 0.17454039975840321 4.092985473927477e-06 2.9571008993724063e-07 0.16899881357006355 0.05633267179205671 4.172516419930724e-11 10.3796019455843 -0.25933897290360064 KVHVIFNYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVHVIFNYK 9 1 P27797;K7EJB9 P27797 CALR Calreticulin 0 1227020000.0 503037000.0 328672000.0 395311000.0 False True 689023372.9637773 314150184.2670402 301946683.4856045 1.0 0.45593545385223877 0.4382241522327548 29.35997768177738 KVHVIFNYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVHVIFNYK 9 1 P27797;K7EJB9 P27797 CALR Calreticulin 0 975278320.0 409203800.0 308991000.0 257083520.0 False True 340271090.5020367 307326404.15308887 310838495.4121064 1.0 0.903181059841607 0.9135025104645083 28.342109343957393 -10.682965322889347 6.62589342661859 1.0007269983271128 0.9083417851530576 0.9905791529713943 0.004213714571906606 4.5606194704300754e-05 2.1821531442280343e-06 0.004111779055306805 0.0013599705302221549 2.075079199685036e-11 10.682965322889347 -0.09238521317405513 KVHVIFNYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVHVIFNYK 9 1 P27797;K7EJB9 P27797 CALR Calreticulin 0 4329214940.0 736582000.0 2223320000.0 1369312940.0 False True 953519919.2019006 2099590287.5446465 1120112035.257249 1.0 2.201936472708416 1.174712780195286 29.82868783610954 -6.607903875796654 2.161468058613445 1.8041537027377765 1.1783217963145411 0.043880998364248636 0.5184731258800915 0.6184976818003024 5.472570976518955 0.1982958210959593 0.575805120050643 2.4665852163825234e-07 6.607903875796654 -0.6258319064232354 KVIQYLAYVASSHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVIQYLAYVASSHK 14 1 P35579;P35579-2;Q5BKV1 P35579 MYH9 Myosin-9 0 27759600.0 11914000.0 6490700.0 9354900.0 False True 15619369.375340102 5522312.8605504455 8386944.68653726 1.0 0.3535554303023966 0.5369579580964766 23.896832870736525 -10.912405080453645 11.49265593498437 1.0546252953533424 0.4452566941994376 0.9242347511869534 0.07487376843868429 0.03727431863548416 0.00028409752348331396 0.02578570771033783 0.0241654048525679 1.223474492822137e-11 10.912405080453645 -0.6093686011539048 KVIQYLAYVASSHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVIQYLAYVASSHK 14 1 P35579;P35579-2;Q5BKV1 P35579 MYH9 Myosin-9 0 25208800.0 6189800.0 0.0 19019000.0 False True 9390379.134994648 0.0 15259886.313676177 1.0 0.0 1.625055399180629 23.1627519769513 -6.740214209021073 1.6857550793770288 0.40513977344926605 1.6260756301844002 0.6059042143227299 0.4201582882775662 0.31746265322056316 1.7714439342565078 0.19715963677165962 0.4837276593418907 1.8188035406814592e-07 6.740214209021073 1.220935856735134 KVIQYLAYVASSHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVIQYLAYVASSHK 14 1 P35579;P35579-2;Q5BKV1 P35579 MYH9 Myosin-9 0 34145200.0 11914000.0 14470000.0 7761200.0 False True 16318927.763743887 13830667.554108871 5928164.406931432 1.0 0.8475230575403835 0.36326923513333775 23.960042932259416 -6.950163058485336 0.5570514221354647 1.0064338563457458 0.18133203353701546 0.9992140116804221 0.007610293576584755 0.08342035407505832 0.035692021572815515 0.008187161316357995 0.040229318011937014 1.1215972647729963e-07 6.950163058485336 -0.8251018228087303 down KVIQYLAYVASSHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVIQYLAYVASSHK 14 1 P35579;P35579-2;Q5BKV1 P35579 MYH9 Myosin-9 0 18789100.0 10186000.0 5258900.0 3344200.0 False True 8470110.316311203 5230569.261890083 4043456.758166239 1.0 0.6175326018856429 0.4773794681728768 23.0139493289358 -13.999999999999998 0.13956881446527733 2.826296568356244 0.30302830431107114 0.9996046580630563 0.0043916223311219645 11.933575949976 0.11701712561530078 5.93702305254508 0.15582282620906662 1.0000000000000041e-14 13.999999999999998 -2.5232682640451727 KVIQYLAYVASSHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVIQYLAYVASSHK 14 1 P35579;P35579-2;Q5BKV1 P35579 MYH9 Myosin-9 0 46745800.0 6189800.0 26100000.0 14456000.0 False True 8012818.11919911 24647512.056256104 11825156.331085864 1.0 3.076010423498749 1.4757799509703338 22.933878299043748 -6.580389621104278 2.265409528718945 2.4133754462688617 1.4797661982763968 0.0 0.9017922384280805 0.6981670445605987 6.7399748534975705 0.33417524390504855 1.0079138886349825 2.62790934262913e-07 6.580389621104278 -0.9336092479924649 KVITMFVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVITMFVQR 9 1 P13010;C9JZ81;H7C0H9 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 26118800.0 8044500.0 8660700.0 9413600.0 False True 10546417.403048806 7368557.319144192 8439570.973627415 1.0 0.698678711219419 0.8002310785829191 23.330249665737714 -10.80084685584806 10.187611765262089 1.0023441802783684 0.7494548949011691 0.890300162598349 0.04145858036870709 0.0022213385527254086 4.342390462706298e-05 0.0403956759779715 0.01338069927711702 1.581805729043166e-11 10.80084685584806 -0.25288928537719924 KVITMFVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVITMFVQR 9 1 P13010;C9JZ81;H7C0H9 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 8472100.0 4167300.0 1138100.0 3166700.0 False True 4035011.3425646937 1592549.2651130932 2337246.2710363464 1.0 0.3946827232710709 0.5792415615740919 21.94414129830154 -10.392979526632063 5.30727191746024 1.0003079829692583 0.4869621424225773 0.9115286863675471 0.07534583022724663 0.0002747346272673867 3.142283726591927e-05 0.07299603508357902 0.02431776213968543 4.0459496453091265e-11 10.392979526632063 -0.513345840546681 KVITMFVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVITMFVQR 9 1 P13010;C9JZ81;H7C0H9 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 24751400.0 6075400.0 5832000.0 12844000.0 False True 9216825.971234359 4791234.034376026 10305377.770274807 1.0 0.5198355756449595 1.1181048446002788 23.135838579855275 -6.693036911734926 1.8557397276063814 0.699828297052851 1.1161103436689492 0.3846516153352988 0.20295210643706021 0.41015852925084073 2.7409014017512874 0.08741667328476599 0.2267619035767622 2.027510389202512e-07 6.693036911734926 0.41628204661609824 KVITMFVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVITMFVQR 9 1 P13010;C9JZ81;H7C0H9 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 13630500.0 4167300.0 5092900.0 4370300.0 False True 3465294.5926922923 5065463.536838495 5284109.524015887 1.0 1.4617699596221005 1.5248658902360455 21.724546573735815 -11.82800310551204 0.32559935921943006 3.425346981335074e-16 1.5378639925738886 0.9995120508161279 0.005168394324769368 4.76733244384949 0.1732280362847586 3.2825090595908386 0.02053782249925738 1.4859250168364835e-12 11.82800310551204 1.5378639925738882 KVITMFVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVITMFVQR 9 1 P13010;C9JZ81;H7C0H9 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 33759400.0 6075400.0 16633000.0 11051000.0 False True 7864725.064037971 15707358.928417895 9039831.392835489 1.0 1.9971911033789267 1.1494148008009557 22.906964901947724 -10.17430913407305 4.39018267273917 0.9998901899224707 1.5733029513527228 0.3787815896546771 0.3461032266193254 242690269.3076869 86.2276346216055 333565.92414959316 0.11848034021544504 6.694079501867557e-11 10.17430913407305 0.5734127614302521 KVLIIGGGDGGVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVLIIGGGDGGVLR 14 1 P19623;K7ESL0 P19623 SRM Spermidine synthase 0 6764490.0 2313900.0 772890.0 3677700.0 False True 3033545.3078394723 657577.8247016228 3297166.882989456 1.0 0.2167687500833662 1.0869021387182571 21.532573428381564 -6.669520828252992 1.938899027689622 0.4998629801587337 1.0833905705190963 0.27697990457098554 0.3327360492662671 0.46222927019615634 3.3495602648759037 0.13817306386764308 0.3694178451459703 2.1403222769689588e-07 6.669520828252992 0.5835275903603625 KVLIIGGGDGGVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVLIIGGGDGGVLR 14 1 P19623;K7ESL0 P19623 SRM Spermidine synthase 0 6117280.0 2313900.0 2831100.0 972280.0 False True 3169411.360796289 2706012.64080426 742647.4887351568 1.0 0.8537902887192265 0.23431716624773272 21.595783489904456 -6.9435555143388665 0.6256187023445272 1.0067613880552144 0.048210076796027714 0.9985934243223537 0.012447538775361955 0.08618154933432884 0.04750098006193874 0.012472131453247074 0.05253936847120315 1.1387922047622261e-07 6.9435555143388665 -0.9585513112591867 down KVLSVAVYNHYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVLSVAVYNHYK 12 1 O76031;H0YM48 O76031 CLPX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial 0 7767200.0 3282600.0 1729500.0 2755100.0 False True 3178395.6598043926 2420098.369223351 2033456.6587716665 1.0 0.7614213673360889 0.6397745518243034 21.599867297820364 -13.999999995920618 0.08646937751883314 2.2417406172848486 0.31629757363716005 0.9998586646376416 0.0017787623941110115 12.196131125243882 0.0845557513203343 2.819487616334019 0.29162734047402433 1.0000000093931246e-14 13.999999995920618 -1.9254430436476886 KVLSVAVYNHYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVLSVAVYNHYK 12 1 O76031;H0YM48 O76031 CLPX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial 0 30341600.0 7942600.0 10952000.0 11447000.0 False True 12049504.881839236 8997530.031633439 9184495.432601666 1.0 0.7467136716293072 0.7622301100889504 23.522470531065903 -10.154098007671646 4.876882257479038 1.0000183965544145 0.754471890858225 0.997013624830685 0.006334559478368703 1.2671550810662409e-06 2.1979275502997515e-07 0.006133870177699734 0.00204447027999393 7.01297018159009e-11 10.154098007671646 -0.24554650569618952 KVLSVAVYNHYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVLSVAVYNHYK 12 1 O76031;H0YM48 O76031 CLPX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial 0 7715800.0 2524900.0 1893400.0 3297500.0 False True 3458423.7628568867 1809743.3273634936 2518698.414144259 1.0 0.5232855923556707 0.7282792933575172 21.72168322347366 -10.262646004535403 5.6124929760340265 1.0000272100938072 0.6257824428565856 0.8162880461700063 0.08368832798989465 2.8496004563694362e-05 3.7437101286143112e-06 0.08103675641135595 0.027010291714729403 5.462028922267073e-11 10.262646004535403 -0.37424476723722166 KVLSVAVYNHYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVLSVAVYNHYK 12 1 O76031;H0YM48 O76031 CLPX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial 0 6311200.0 3282600.0 1583600.0 1445000.0 False True 2729627.3438369455 1575068.8324800124 1747142.8190748815 1.0 0.5770270568384588 0.6400664262906238 21.38027257325464 -10.519492169045922 6.237724282634825 1.0003939168399685 0.6085467415645789 0.9809208446270787 0.02573571481076629 0.0001411209771736827 1.0870873719518284e-05 0.02494277230622862 0.008306166238736775 3.023485087804103e-11 10.519492169045922 -0.3918471752753896 KVLSVAVYNHYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVLSVAVYNHYK 12 1 O76031;H0YM48 O76031 CLPX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial 0 40908600.0 7942600.0 20528000.0 12438000.0 False True 10281852.272052547 19385598.754437726 10174411.624657305 1.0 1.8854189149488543 0.9895504579765962 23.293596853158352 -6.648840670371509 2.0124631084828266 1.575065128517935 0.9932973036203668 0.18946544958534006 0.3780122897916833 0.5113616943136605 3.9682705758718435 0.15239833144139142 0.4187294195634397 2.2447052878302657e-07 6.648840670371509 -0.5817678248975681 KVNIDFEPFKPINTSLYLCDNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVNIDFEPFKPINTSLYLCDNK 22 2 P62495;B7Z7P8;P62495-2;I3L492;D6RJE8 P62495 ETF1 Eukaryotic peptide chain release factor subunit 1 0 47581000.0 12493000.0 19173000.0 15915000.0 False True 18952794.360639784 15751428.350667255 12769393.2742077 1.0 0.8310873874819764 0.673747260231269 24.175907236250726 -6.971979812856468 0.20548164754653678 1.0872771703598614 0.4131872708392549 0.9999939809795241 0.0003267869724015533 0.0756654978117649 0.006680131839127332 0.004885142162226039 0.016479079818828807 1.0666457005602199e-07 6.971979812856468 -0.6740898995206065 KVNIDFEPFKPINTSLYLCDNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVNIDFEPFKPINTSLYLCDNK 22 2 P62495;B7Z7P8;P62495-2;I3L492;D6RJE8 P62495 ETF1 Eukaryotic peptide chain release factor subunit 1 0 29370100.0 12493000.0 8967700.0 7909400.0 False True 16172434.773846406 8468639.611758158 6469970.357297345 1.0 0.5236465461251015 0.4000616139605889 23.947033558343175 -13.999999999999998 0.18942511532352163 3.548490113326416 0.3108859118851473 0.9994897337107823 0.005842726846062777 12.34144771026599 0.13801992934159985 11.606772551759688 0.0853813148568489 1.0000000000000041e-14 13.999999999999998 -3.2376042014412687 KVNLGVGAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVNLGVGAYR 10 1 P17174 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 13673800.0 5373200.0 4099700.0 4200900.0 False True 7044317.234142821 3488040.740505435 3766231.165878242 1.0 0.49515668084898123 0.5346481483860275 22.748028450358582 -10.6232544585828 5.8739551580297045 1.0029705898743293 0.5149024146175047 0.9950539753327382 0.01612232410990836 0.0006300160884927785 4.040810739692918e-05 0.01568058174136989 0.005203457731652761 2.380924047345954e-11 10.6232544585828 -0.48806817525682455 KVNLGVGAYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVNLGVGAYR 10 1 P17174 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 8781800.0 2809900.0 1006500.0 4965400.0 False True 2720701.2625614987 1408400.698828162 3664812.7811929984 1.0 0.5176609127244548 1.3470103578158497 21.37554712433818 -6.7490134113774625 1.653286164796701 0.7160519097773405 1.3485592855424302 0.6448340098232429 0.20267321955746795 0.30175171882982876 1.6224411783940504 0.0968482476343526 0.2353847664108441 1.782323726948288e-07 6.7490134113774625 0.6325073757650898 KVNLGVGAYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVNLGVGAYR 10 1 P17174 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 21591100.0 10150000.0 6740400.0 4700700.0 False True 15398292.064395558 5537522.957014431 3771604.584610003 1.0 0.3596192963386164 0.24493655327728406 23.876267004295784 -13.999999999999998 0.24190929943309714 5.278261863624914 0.19514053079665725 0.9995281691782093 0.007216476112084292 13.691597812349643 0.1556602137177618 28.32839671722103 0.05541651680784522 1.0000000000000041e-14 13.999999999999998 -5.083121332828257 KVNLGVGAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVNLGVGAYR 10 1 P17174 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 11015300.0 5373200.0 2717600.0 2924500.0 False True 7359817.245270169 2597527.4460985707 2233793.3319681208 1.0 0.3529336883694887 0.3035120652491312 22.811238511881474 -13.999999999999998 0.3648000324181965 9.723932120430678 0.29796431738653795 0.9997818663538872 0.0046866187103723695 22.224533029130384 0.19559333891560535 151.27387340978584 0.014041482628877236 1.0000000000000041e-14 13.999999999999998 -9.42596780304414 KVNLGVGAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVNLGVGAYR 10 1 P17174 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 6989300.0 2809900.0 2761400.0 1418000.0 False True 2336556.3496763064 2746523.790105015 1714497.2439087739 1.0 1.1754579727920977 0.7337709805912838 21.155952399772456 -6.798917444557424 1.460294726895566 1.0969426742605335 0.7278337308445357 0.8289771184041035 0.07509340478890661 0.22231379057691 0.9360452187557695 0.040456359131322284 0.09415072684476838 1.5888487456313646e-07 6.798917444557424 -0.36910894341599776 KVNLGVGAYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVNLGVGAYR 10 1 P17174 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 30653200.0 10150000.0 12684000.0 7819200.0 False True 13139375.086411664 11978124.249867894 6396185.831767184 1.0 0.9116205429172427 0.4867952843801469 23.647393326388233 -6.940687894619088 0.6531324617650668 1.0047177920159525 0.36987725228560375 0.9982526212912255 0.009364425245294366 0.08745420771662103 0.053191001676204795 0.009163794947376167 0.03645445743381858 1.1463364592764394e-07 6.940687894619088 -0.6348405397303487 down KVNVTVDYIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVNVTVDYIR 10 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 14600900.0 5533700.0 4118700.0 4948500.0 False True 7254734.288427036 3504206.0145668527 4436476.6893638205 1.0 0.4830233438262328 0.6115284878787384 22.79049134449991 -10.12022118643718 7.729138776951316 1.0000000717630773 0.547275915852541 0.9430158482230813 0.05246200537524785 6.488290136417112e-08 7.4427471911806645e-09 0.050796126607794215 0.016932039427248243 7.581913293862848e-11 10.12022118643718 -0.4527241559105363 KVNVTVDYIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVNVTVDYIR 10 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 10333200.0 4402400.0 1069500.0 4861300.0 False True 4262648.221751927 1496556.9273688213 3587979.694126054 1.0 0.3510861909110914 0.8417254972664416 22.02331857004599 -9.949154382570116 6.660983558725029 1.0000000403905254 0.5964058440888801 0.47429348435960983 0.20030265805396444 1.202559920768124e-07 1.9090041345623252e-08 0.19394223494068746 0.06464740490367107 1.1242052715573655e-10 9.949154382570116 -0.4035941963016453 KVNVTVDYIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVNVTVDYIR 10 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 12162500.0 2951100.0 5517600.0 3693800.0 False True 4477034.454309142 4532941.170794429 2963718.8109499454 1.0 1.0124874438773812 0.6619825782438123 22.094111990283896 -6.898639326068506 0.9698451722007901 1.0151217516291615 0.6261931078999157 0.985876663215984 0.01929587893670366 0.11241325186120499 0.18312909495658822 0.014959585361335149 0.03866262441855348 1.2628758954351803e-07 6.898639326068506 -0.38892864372924585 KVNVTVDYIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVNVTVDYIR 10 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 14357000.0 5533700.0 4601500.0 4221800.0 False True 7579658.432619585 4398190.514874357 3224697.790700294 1.0 0.5802623632677746 0.4254410432035544 22.8537014060228 -13.999999999999952 0.1385939968236665 3.0026640900257617 0.23055681665258174 0.9996085982160905 0.004802167045379754 11.93282739178572 0.11653458310201771 6.468210174358767 0.17406458432198868 1.0000000000001104e-14 13.999999999999952 -2.77210727337318 KVNVTVDYIRPASPATETVPAFSER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVNVTVDYIRPASPATETVPAFSER 25 2 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 24180700.0 4566900.0 11919300.0 7694500.0 False True 5987250.12592251 10140986.901067492 6898346.950855796 1.0 1.6937636958176985 1.1521728349027183 22.51346211146906 -10.282008416846475 3.803040424705959 0.9992162257084742 1.4229682654617029 0.4484969907620687 0.22110354346804253 14394038.206418384 13160078.082307981 82034.03779380511 0.07568962464020267 5.223860647951567e-11 10.282008416846475 0.4237520397532286 KVNVTVDYIRPASPATETVPAFSER ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVNVTVDYIRPASPATETVPAFSER 25 2 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 23106100.0 5459400.0 6015700.0 11631000.0 False True 5286094.335324475 8417800.381461067 8584492.177479316 1.0 1.5924423302870094 1.6239763486839809 22.333770740783113 -11.424845240579533 0.48388658426477676 2.0055095995774858e-13 1.623003687149026 0.9998278219469328 0.003765932793845721 3.9197841643732687 0.23806531908874265 4.145254443417529 0.006618452626480768 3.759713565855054e-12 11.424845240579533 1.6230036871488256 KVNVTVDYIRPASPATETVPAFSER ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVNVTVDYIRPASPATETVPAFSER 25 2 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 157492000.0 26041000.0 87315000.0 44136000.0 False True 39506100.85211083 71732956.05479118 35412500.25450399 1.0 1.8157437587505791 0.8963805460596823 25.235572127360467 -6.672612058982547 1.928476919626881 1.5195177247316176 0.9000790664911845 0.29056560296123224 0.3463036620327727 0.45511432155028053 3.265690117722108 0.14445200212296835 0.3845788361192589 2.1251419339922453e-07 6.672612058982547 -0.6194386582404331 KVNVTVDYIRPASPATETVPAFSER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVNVTVDYIRPASPATETVPAFSER 25 2 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 27377900.0 4566900.0 12515000.0 10296000.0 False True 6255406.345831965 11962045.918429336 7864296.852776126 1.0 1.912273201308458 1.2571999991681082 22.57667217299195 -10.137115847351716 5.868212410824164 0.999994949055227 1.5847366002383025 0.5151231544364469 0.2674325149025551 1.7672678298940903e-05 2.598594783654794e-06 0.2589426519800661 0.08631347303765355 7.292629545915505e-11 10.137115847351716 0.5847416511830755 KVNVTVDYIRPASPATETVPAFSER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVNVTVDYIRPASPATETVPAFSER 25 2 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 15369000.0 5459400.0 4634500.0 5275100.0 False True 4539732.992427782 4609533.028623779 6378099.020693353 1.0 1.0153753615713574 1.4049502539757168 22.11417601621739 -6.915222153770702 0.8594197328061398 0.9898372713312173 1.461351526701197 0.992747381856212 0.015957416883897 0.10106520858446051 0.1207869803258611 0.013411738494707314 0.038509289531611604 1.2155640465885467e-07 6.915222153770702 0.4715142553699796 KVNVTVDYIRPASPATETVPAFSER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVNVTVDYIRPASPATETVPAFSER 25 2 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 81741800.0 26041000.0 37151800.0 18549000.0 False True 33710587.84485185 35084269.67094309 15173272.328812351 1.0 1.0407492694109461 0.45010405628775035 25.006698449452916 -6.890362111139468 1.0202082891501825 1.03146099862411 0.39893551451069864 0.9811300985013367 0.03699895786856708 0.11885101733214343 0.2201208891940269 0.027618984804892856 0.06894692178056792 1.2871758675709357e-07 6.890362111139468 -0.6325254841134113 down KVPLDMSLFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVPLDMSLFLK 11 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 0 13608700.0 4433100.0 3699500.0 5476100.0 False True 5811837.03020147 3147549.0205380516 4909485.702460381 1.0 0.5415755817277176 0.8447390518605427 22.470562818231514 -10.174735254476664 5.363352037002162 1.0000115008626753 0.6931573167940532 0.5773265380322061 0.12376596841308986 1.7021003584752807e-05 2.619130720009041e-06 0.11984037229387114 0.039945294540888285 6.687514636234604e-11 10.174735254476664 -0.3068541840686221 KVPLDMSLFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVPLDMSLFLK 11 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 0 8483600.0 3587500.0 1532800.0 3363300.0 False True 3473616.776198218 2144855.033446401 2482350.8331627673 1.0 0.6174702541003639 0.7146300219909794 21.728007168054404 -9.934442787641158 6.658109833558348 1.0000000268586582 0.666050138045669 0.9403046817648151 0.039665309143227474 1.578424125055483e-08 2.5786176896596253e-09 0.03840577329491058 0.012801923477821399 1.1629397423200917e-10 9.934442787641158 -0.33394988881298915 KVPLDMSLFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVPLDMSLFLK 11 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 0 16758700.0 4433100.0 3381600.0 8944000.0 False True 6072136.870022926 3232189.7305441992 6831611.407462086 1.0 0.5322985630480355 1.12507533240704 22.533772879754405 -6.696378777169681 1.8439951941302304 0.7085505281703139 1.1231859491652394 0.4003537809415266 0.19755630065449337 0.4030821680812512 2.662097828097932 0.08555786131319061 0.22100380578599227 2.0119687123721378e-07 6.696378777169681 0.41463542099492545 KVPLDMSLFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVPLDMSLFLK 11 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 0 7932900.0 3587500.0 2125900.0 2219500.0 False True 2983165.2031971766 2114447.3547418886 2683587.1881914875 1.0 0.7087932483510304 0.8995771287876986 21.50841244348868 -10.168295102949767 4.788929061752209 1.000020364284273 0.8041851892289799 0.5841269441855956 0.07788719303963552 1.6936393060420385e-05 2.941332333300248e-06 0.07542178985242237 0.02513798345997656 6.787422707498498e-11 10.168295102949767 -0.19583517505529324 KVPNQYTHLSGLLDIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVPNQYTHLSGLLDIFK 17 1 Q15042;Q15042-3;Q15042-4 Q15042 RAB3GAP1 Rab3 GTPase-activating protein catalytic subunit 0 4299250.0 804050.0 1370500.0 2124700.0 False True 1054117.3364312775 1166026.7421671578 1904856.4255615452 1.0 1.1061640880651396 1.8070629897905404 20.00760403522306 -6.933846647495376 0.714511776791779 0.9907112082362511 1.9661439280827973 0.9972417478775155 0.01880512264230638 0.09068898239218244 0.06825198168045489 0.017542812743223144 0.06213247303856413 1.1645371632657343e-07 6.933846647495376 0.9754327198465461 KVPNQYTHLSGLLDIFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVPNQYTHLSGLLDIFK 17 1 Q15042;Q15042-3;Q15042-4 Q15042 RAB3GAP1 Rab3 GTPase-activating protein catalytic subunit 0 21823100.0 7330200.0 4425900.0 10067000.0 False True 7097506.813348612 6193184.950763601 7430150.696473581 1.0 0.8725859817585225 1.0468677088832588 22.758880898209316 -6.710730725165054 1.7925392792342456 0.9217250749526494 1.0464673254205263 0.46850702133183975 0.05368584860886153 0.37365724752286533 2.340869134470806 0.02382914166905129 0.060485020092667784 1.946566633782554e-07 6.710730725165054 0.1247422504678769 KVPNQYTHLSGLLDIFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVPNQYTHLSGLLDIFK 17 1 Q15042;Q15042-3;Q15042-4 Q15042 RAB3GAP1 Rab3 GTPase-activating protein catalytic subunit 0 14834550.0 804050.0 4655000.0 9375500.0 False True 1101329.0136342372 4449326.707973518 7161199.994483553 1.0 4.039961403805517 6.502325740836119 20.070814096745952 -7.746082402057427 0.26760371154268225 1.1427083164550235e-19 8.65425308447847 0.9996267782775946 0.04347606937483391 0.13187278773517794 0.040409391278417896 0.3378879619966747 0.6598396728147492 1.7943931304175368e-08 7.746082402057427 8.65425308447847 KVPNQYTHLSGLLDIFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVPNQYTHLSGLLDIFK 17 1 Q15042;Q15042-3;Q15042-4 Q15042 RAB3GAP1 Rab3 GTPase-activating protein catalytic subunit 0 21560900.0 7330200.0 6294500.0 7936200.0 False True 6095386.082920115 6260590.279139568 9595622.727157148 1.0 1.0271031553985353 1.574243632252442 22.539286173643593 -6.917198580529293 0.8452322329841948 0.9866665419638314 1.6570330425318027 0.9933670005466331 0.021545338543208045 0.09984822202662814 0.11435851004649661 0.018293271838478002 0.053412640215048116 1.2100447158236713e-07 6.917198580529293 0.6703665005679713 KVPVSVNLLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVPVSVNLLSK 11 1 O76021;J3QSV6;I3L3C4 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 51851000.0 12309000.0 11737000.0 27805000.0 False True 16137218.200525543 9985885.350467663 24928005.324393477 1.0 0.6188108276395774 1.5447523243864698 23.94388856660665 -6.794912188545154 1.4764883881247843 0.7882983568493577 1.5559968996635678 0.816863962178656 0.1626079413419157 0.22812389402407338 0.9822441303818655 0.08666000358155812 0.20220512499059695 1.6035695890157919e-07 6.794912188545154 0.7676985428142101 KVPVSVNLLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVPVSVNLLSK 11 1 O76021;J3QSV6;I3L3C4 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 37966300.0 12950000.0 7764300.0 17252000.0 False True 12538909.338471625 10864625.480289616 12733183.6510939 1.0 0.8664729273506264 1.015493716987506 23.57990852906527 -13.800127677733897 22.690128350765264 0.9418450740943689 0.9468849903878981 0.0 0.06829949119777194 0.0 0.0 0.0 0.01998078970994364 1.5844273200231997e-14 13.800127677733897 0.005039916293529179 KVPVSVNLLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVPVSVNLLSK 11 1 O76021;J3QSV6;I3L3C4 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 23751200.0 5206500.0 14201000.0 4343700.0 False True 7898641.1461355155 11666720.597080579 3485165.791088656 1.0 1.4770541389627039 0.44123612234160126 22.913173047885685 -6.781492341656016 1.530217493338829 1.2695975693058115 0.43266647820310333 0.772581613060285 0.2018694372049198 0.24826301521578922 1.148340929589171 0.10389805062496499 0.24483516168121777 1.653893949261386e-07 6.781492341656016 -0.8369310911027081 down KVPVSVNLLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVPVSVNLLSK 11 1 O76021;J3QSV6;I3L3C4 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 36925500.0 12309000.0 9606500.0 15010000.0 False True 16859969.938217517 9182053.065552644 11464947.14065361 1.0 0.5446067281970134 0.6800099396776099 24.00709862812954 -10.657523545771951 9.952590444516131 1.00015134169008 0.6123083339373154 0.9161836393594034 0.05527812961027045 0.00018570104333202558 6.390156739892077e-06 0.05354306815988145 0.017840939615839383 2.2002724161185623e-11 10.657523545771951 -0.3878430077527646 KVPVSVNLLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVPVSVNLLSK 11 1 O76021;J3QSV6;I3L3C4 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 24482300.0 12950000.0 5816300.0 5716000.0 False True 10768498.782272743 5784966.437454846 6911189.172202089 1.0 0.5372119693209364 0.6417969033510398 23.360313804499548 -10.52956447285497 6.10453187239944 1.0005514673420528 0.5895044363360092 0.953576474645862 0.04269662052606564 0.0003208664551203839 2.4727031617543936e-05 0.04139386525442625 0.013780275019732495 2.9541702968339936e-11 10.52956447285497 -0.41104703100604356 KVQTEVLQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVQTEVLQKR 10 2 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 4100550.0 1133500.0 745850.0 2221200.0 True False 1097517.662946531 1043671.7945563662 1639401.0854283425 1.0 0.950938494925354 1.493735491260345 20.065812727344777 -6.884825967840819 1.0524840142283132 0.9671159633006321 1.53595361339562 0.9773755421656415 0.036871459261485155 0.12344256314968763 0.24716409550009272 0.026857711134951272 0.06582497796356886 1.3036890931130135e-07 6.884825967840819 0.5688376500949879 KVQTEVLQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVQTEVLQKR 10 2 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 3256780.0 1133500.0 1341400.0 781880.0 True False 942555.4725641812 1334173.6119529458 945367.4929953413 1.0 1.4154855080554405 1.0029834004607816 19.846218002779054 -9.806997131193954 12.11002083377851 1.000000114783084 1.2092344542500952 0.2554240548498997 0.168403280238273 0.0 0.0 0.1630557749523771 0.05435192498412569 1.5595628047502157e-10 9.806997131193954 0.2092343394670113 KVSK(ub)YIQEQNEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVSKYIQEQNEK 12 2 Q7Z5G4-3;Q7Z5G4 Q7Z5G4-3 GOLGA7 Golgin subfamily A member 7 1 2589760.0 592940.0 915720.0 1081100.0 True False 574117.444258947 1281371.771416716 797927.4776952002 1.0 2.231898341062726 1.3898331877463508 19.13098636624793 -10.122085353125648 4.553444811664368 0.9999197218034698 1.8108657644270874 0.5528449880838202 0.3437716593733469 239818041.1826679 33.80157536239751 205045.33743351942 0.11768218278273625 7.549438418312493e-11 10.122085353125648 0.8109460426236176 KVTHAVVTVPAYFNDAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVTHAVVTVPAYFNDAQR 18 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 48215900.0 20687000.0 21755000.0 5773900.0 False True 27120857.33319294 18509238.800325803 5176472.215159698 1.0 0.6824724813427094 0.19086683549727856 24.692899449278563 -7.303534975078306 0.45363793234565974 1.0190731544318978 1.4847777169687632e-12 0.9990540346023089 0.0102377998290716 0.10124223607650525 0.040456063012096574 0.013012657842413724 0.05451187073674703 4.9712433715218935e-08 7.303534975078306 -1.019073154430413 down KVTHAVVTVPAYFNDAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVTHAVVTVPAYFNDAQR 18 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 27111900.0 8913400.0 4813500.0 13385000.0 False True 8630448.995948475 6735555.652070895 9879066.958607225 1.0 0.7804409313157253 1.1446758984665697 23.04100418636202 -6.7434607521049195 1.6737839784414057 0.8698933908869317 1.145065859540359 0.6205070077978259 0.09224566222049647 0.3115758037499625 1.715156562235322 0.04357432916427697 0.10653400761321563 1.8052578738352194e-07 6.7434607521049195 0.27517246865342737 KVTHAVVTVPAYFNDAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVTHAVVTVPAYFNDAQR 18 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 45264000.0 20687000.0 12598000.0 11979000.0 False True 28335542.94515442 12041378.703985047 9149806.915249145 1.0 0.42495669581105405 0.32290917922269163 24.756109510801455 -13.999999999999998 0.24320243357846066 4.866160523451385 0.27914004297793227 0.9995303920794446 0.006459018165023337 13.73865659750957 0.1560702343703078 25.844578913201907 0.048943007769029385 1.0000000000000041e-14 13.999999999999998 -4.587020480473453 KVTLSVLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVTLSVLSR 9 1 O00625 O00625 PIR Pirin 0 16426200.0 4587400.0 3762500.0 8076300.0 False True 6014125.824444787 3201149.666110131 7240641.949340004 1.0 0.532271814649913 1.2039392192145308 22.519923620874867 -6.719451832565788 1.7613111551217893 0.715272492004105 1.2028580588502447 0.5099118300555402 0.19683516352068864 0.3563872574216842 2.16039568284349 0.08874561683044604 0.22292650263655864 1.9078673130872615e-07 6.719451832565788 0.48758556684613963 KVTLSVLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVTLSVLSR 9 1 O00625 O00625 PIR Pirin 0 15021900.0 7871300.0 2279800.0 4870800.0 False True 7621429.890031783 3190136.0289999396 3594991.35913217 1.0 0.4185744768409378 0.47169512952341525 22.86163026280804 -10.556054086132953 9.875170501846656 1.0000229163734544 0.445134804207347 0.9931728730616525 0.021686415645946054 1.0942052315936452e-05 4.919130234539402e-07 0.020998643298373268 0.006999260552973423 2.7793671095964232e-11 10.556054086132953 -0.5548881121661073 KVTLSVLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVTLSVLSR 9 1 O00625 O00625 PIR Pirin 0 29782000.0 9568300.0 9059700.0 11154000.0 False True 14515810.636429176 7442925.751240813 8949407.01102813 1.0 0.5127461316257388 0.6165282280941661 23.791121805828215 -9.920620669506272 13.708878835119927 0.9999997731793822 0.5646371726326593 0.9591231114284005 0.04236886346419395 0.0 0.0 0.04102347564854886 0.013674491882849617 1.2005474523900503e-10 9.920620669506272 -0.4353626005467228 KVTLSVLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVTLSVLSR 9 1 O00625 O00625 PIR Pirin 0 20192000.0 4587400.0 5499600.0 10105000.0 False True 6283485.749823628 5256609.487254821 7718407.119007659 1.0 0.8365753813323074 1.2283639091923313 22.583133682397758 -6.793392554062843 1.4825988386047741 0.9090635163984997 1.2329382220514569 0.8121777293857368 0.06963525481209286 0.23032804305485594 1.0000434887063343 0.036961590170465755 0.08633295505788394 1.6091904478541232e-07 6.793392554062843 0.3238747056529572 KVTLSVLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVTLSVLSR 9 1 O00625 O00625 PIR Pirin 0 13168100.0 7871300.0 3384900.0 1911900.0 False True 6545334.707714545 3366664.871849954 2311669.450373193 1.0 0.514360994844449 0.35317818776304655 22.642035538242315 -13.999999999999998 0.15412268526404427 3.3644274900674125 0.18398353890508842 0.9995530672375468 0.005811912794294413 11.975608181662095 0.1238371872049443 8.471292357210817 0.1531484486841865 1.0000000000000041e-14 13.999999999999998 -3.180443951162324 KVTLSVLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVTLSVLSR 9 1 O00625 O00625 PIR Pirin 0 38599300.0 9568300.0 18369000.0 10662000.0 False True 12386352.969390426 17346749.00235128 8721625.401358431 1.0 1.4004726851575402 0.7041318314528584 23.562248127920665 -6.750756606807426 1.6471081606532245 1.2352707002669918 0.7026740743606872 0.6521767228372088 0.16828788411706436 0.29873676490911016 1.5948254637475074 0.08070442423065487 0.19576823591489328 1.7751840748520483e-07 6.750756606807426 -0.5325966259063046 KVTSVVFHPSQDLVFSASPDATIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVTSVVFHPSQDLVFSASPDATIR 24 1 Q9UMS4 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 7358700.0 2768000.0 3213100.0 1377600.0 False True 3628874.805350128 2733718.0045657014 1235059.1668723044 1.0 0.7533238679205252 0.34034218128755234 21.791090854629683 -6.963367329740224 0.3850459600562351 1.0268066181229398 0.05213761436696183 0.999875433753358 0.0030373509894108604 0.07851944385874236 0.01684106268977193 0.005349947773709389 0.03481473544216383 1.0880094569620967e-07 6.963367329740224 -0.974669003755978 down KVTSVVFHPSQDLVFSASPDATIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVTSVVFHPSQDLVFSASPDATIR 24 1 Q9UMS4 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 7594400.0 2911300.0 1864000.0 2819100.0 False True 2818882.37506505 2608304.920631589 2080693.138812822 1.0 0.9252975376708998 0.738126981536364 21.42669184842059 -6.955414081756955 0.49585832683320286 1.0038868264193785 0.6515214976394883 0.9995605055299484 0.0023091227807952347 0.08138182790935268 0.02750826365337841 0.0027295730882949975 0.015438163768048083 1.1081177671338787e-07 6.955414081756955 -0.35236532877989024 KVTSVVFHPSQDLVFSASPDATIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVTSVVFHPSQDLVFSASPDATIR 24 1 Q9UMS4 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 25389700.0 4272300.0 12006000.0 9111400.0 False True 5530576.569623315 11337855.545877812 7453218.69085885 1.0 2.050031385181605 1.3476386407514263 22.398998460412717 -10.238756738415137 4.942052918462284 0.9998791440561448 1.6988350129672207 0.5689395881885018 0.28675063715030374 0.0003819070538624818 5.88265955247132e-05 0.27769259008819586 0.09254837018277266 5.7708961837523054e-11 10.238756738415137 0.698955868911076 KVVGCSCVVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVVGCSCVVVK 11 1 P25398 P25398 RPS12 40S ribosomal protein S12 0 95130700.0 39086100.0 26403000.0 29641600.0 False True 51242255.61033087 22463775.318087917 26574571.574304674 1.0 0.438383811378495 0.5186065925042342 25.610830646647845 -10.688259570152322 6.760437373837511 1.0040715207608781 0.47849520194157585 0.9825618667172354 0.03275081325083969 0.0020173887185210857 9.30266542994693e-05 0.031830387150039066 0.010570279524604273 2.049936601656379e-11 10.688259570152322 -0.5255763188193023 KVVGCSCVVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVVGCSCVVVK 11 1 P25398 P25398 RPS12 40S ribosomal protein S12 0 19316900.0 13403000.0 3234400.0 2679500.0 False True 12977529.101431273 4525912.787173178 1977658.5667230529 1.0 0.34874996247737344 0.15239099456189545 23.62951238711319 -12.956383140629253 0.1842967948970224 3.2930135490571955 1.6939585565560328e-19 0.9994608560184749 0.008411604787641304 8.14493060614342 0.12931866482323098 6.910328677413309 0.13982552329375386 1.1056479356085697e-13 12.956383140629253 -3.2930135490571955 KVVGCSCVVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVVGCSCVVVK 11 1 P25398 P25398 RPS12 40S ribosomal protein S12 0 242022600.0 40126600.0 145355000.0 56541000.0 False True 60874985.84740639 119415264.58620146 45365646.56719933 1.0 1.961647512913372 0.7452264002313875 25.85934619599988 -6.695993260672109 1.8453286256239696 1.5994735950691061 0.7491223298466457 0.3985515753007517 0.4062279307715268 0.40389333868122795 2.67102362938414 0.17581950619854528 0.45438254832256814 2.013755498827929e-07 6.695993260672109 -0.8503512652224604 KVVGCSCVVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVVGCSCVVVK 11 1 P25398 P25398 RPS12 40S ribosomal protein S12 0 85047000.0 39086100.0 20270000.0 25690900.0 False True 53537287.432136245 19374404.376073733 19623238.540694077 1.0 0.3618861788736063 0.36653404537105944 25.674040708170736 -10.04281029778597 5.418539660643106 1.000004137549946 0.3642101121217024 0.9999599199794043 0.0018974835541035696 9.484344188249347e-08 1.6754122243701472e-08 0.0018372424815232804 0.000612410183408336 9.061283162899024e-11 10.04281029778597 -0.6357940254282436 KVVGCSCVVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVVGCSCVVVK 11 1 P25398 P25398 RPS12 40S ribosomal protein S12 0 25542930.0 13403000.0 1512900.0 10627030.0 False True 11145188.353575397 1504749.7074128608 12849092.839164939 1.0 0.135013394092181 1.1528825203786641 23.409917662547468 -6.68150356161702 1.8960381083115943 0.45348351419304134 1.149107316645682 0.3313099115879752 0.3664766028356972 0.4351531564999522 3.0256782472251724 0.15500306522639334 0.40810029869866754 2.082075330203857e-07 6.68150356161702 0.6956238024526407 KVVGCSCVVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVVGCSCVVVK 11 1 P25398 P25398 RPS12 40S ribosomal protein S12 0 186561700.0 40126600.0 85092200.0 61342900.0 False True 51944674.713537574 80356744.26794465 50179121.63130651 1.0 1.5469678982704738 0.9660108934752664 25.63047251809233 -8.778307379220449 18.642998558257815 1.00000520646393 1.2564893958728702 0.20627991752909125 0.2371747040596988 0.0 0.0 0.22964341973261423 0.07654780657753806 1.6660676078002398e-09 8.778307379220449 0.25648418940894024 KVVK(ub)QASEGPLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVVKQASEGPLK 12 2 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 12338500.0 4308000.0 3892000.0 4138500.0 True False 4171244.8980799774 5446095.896511877 3054502.6976612625 1.0 1.3056284225888326 0.732276040437532 21.9920465861482 -6.761863515774094 1.6052100264663047 1.1771084005693 0.7299666690290917 0.6986580153826284 0.12858548271692558 0.2797792458576701 1.4212015375083191 0.0631881701616616 0.15158793480612046 1.7303600680543422e-07 6.761863515774094 -0.4471417315402083 KVVK(ub)QASEGPLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVVKQASEGPLK 12 2 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 42192300.0 6713700.0 8357600.0 27121000.0 True False 10185173.737215018 6866120.981773149 21760522.462443423 1.0 0.6741289995560338 2.1364900613264854 23.2799672540078 -6.848225899175043 1.2436408510306756 0.8263356324720933 2.192973880148694 0.937684027769523 0.15647792256936524 0.15941659681426731 0.4753629751581374 0.09850058383563835 0.22769037775515316 1.418319587913046e-07 6.848225899175043 1.366638247676601 up KVVK(ub)QASEGPLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVVKQASEGPLK 12 2 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 11219400.0 4308000.0 5341400.0 1570000.0 True False 3582292.8767591454 5312624.81801511 1898279.74114018 1.0 1.483023583158665 0.5299063494935482 21.772451861582475 -6.768936708638575 1.5785520551431769 1.277427512215332 0.5247641755870318 0.7264586708644358 0.20351456398782589 0.2681569839299373 1.3185616209782798 0.10163202912427446 0.24216039359504474 1.7024065884059023e-07 6.768936708638575 -0.7526633366283002 KVVK(ub)QASEGPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVVKQASEGPLK 12 2 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 30613500.0 6713700.0 6409800.0 17490000.0 True False 8691016.996812018 6053088.995332959 14306999.462554753 1.0 0.6964764880281921 1.6461824281097084 23.05109357610025 -6.820717752774164 1.3687295880744719 0.8365195889428828 1.6672426365584658 0.886033800142639 0.13369821908506765 0.19255040040193275 0.7086089525726891 0.0767554103078465 0.1768790328752405 1.511061871594539e-07 6.820717752774164 0.830723047615583 KVVNPLFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVVNPLFEK 9 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 0 7847200.0 2254500.0 1015100.0 4577600.0 False True 2182932.1315509095 1420434.7236765667 3378589.234943629 1.0 0.650700359917919 1.5477298566049509 21.057835846241513 -6.801106351481145 1.4512927567277087 0.8075361625065506 1.5604638868985472 0.8353674751385705 0.1497966957137014 0.219206157699555 0.9113822390884913 0.08119251205143704 0.18870636833740398 1.5808608653850522e-07 6.801106351481145 0.7529277243919966 KVVNPLFEK(ub)RPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVVNPLFEKRPK 12 3 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 14307100.0 2037800.0 3697500.0 8571800.0 True False 1973111.1544353263 5173931.032207772 6326588.43151209 1.0 2.622219747010893 3.206402445848349 20.91204080132866 -9.64003022809198 0.2848593171978049 3.874305231352445e-15 3.4617088868310613 0.9988517196791398 0.031629373410597926 1.0253079778197183 0.11846182162662391 1.1371080362360109 0.21917207554032397 2.2907082076191037e-10 9.64003022809198 3.4617088868310573 KVVNPLFEK(ub)RPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVVNPLFEKRPK 12 3 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 6729050.0 1739550.0 1038400.0 3951100.0 True False 2382708.64457115 992520.0544703971 3017931.555458794 1.0 0.4165511619441138 1.2665969724560988 21.1841711202101 -6.7220247354607645 1.7524157344291516 0.645793334807378 1.265387631842929 0.5218512076913102 0.24545909590642676 0.3514141034460523 2.110213422805362 0.11117930074736877 0.2783984957268798 1.8965978964472661e-07 6.7220247354607645 0.6195942970355509 KVVNPLFEK(ub)RPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVVNPLFEKRPK 12 3 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 11738100.0 2037800.0 5828100.0 3872200.0 True False 1694520.9898467488 5796702.868512732 4681859.116970068 1.0 3.420850436934972 2.7629395829398913 20.692446076762938 -10.170559278625907 5.3657703245482455 0.9999258842602606 3.0918950099379634 0.9309384137200639 0.2685909814230384 0.0002381719205084905 3.6818090144474126e-05 0.2600710918034569 0.08668736649913267 6.752128851431744e-11 10.170559278625907 2.0919691256777027 KVVQLDVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVVQLDVR 8 1 O95831-3;O95831;O95831-6;O95831-4 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 0 4112700.0 1459800.0 1266700.0 1386200.0 False True 1913811.9367233077 1077713.297557927 1242769.3213693283 1.0 0.5631239292002279 0.6493685704025388 20.86801763776518 -10.11024636018117 5.369436171351575 1.000006572780435 0.6062462498011829 0.9652684458070314 0.03520922733326311 2.770424589659168e-06 4.5905937589254386e-07 0.03409175701437232 0.01136372925777143 7.758069034608358e-11 10.11024636018117 -0.3937603229792521 KVVQLDVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVVQLDVR 8 1 O95831-3;O95831;O95831-6;O95831-4 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 0 6920700.0 1150400.0 3855300.0 1915000.0 False True 1745240.9055054837 3167291.5934036104 1536499.410625684 1.0 1.814816271731982 0.8803938790219104 20.73499476288782 -6.676240851372808 1.9153026361311218 1.5172732582794732 0.8840516601953994 0.3069930383359173 0.34562578310846737 0.4469206730336182 3.166417794731291 0.14497646852438592 0.3842087710328483 2.1074590694925252e-07 6.676240851372808 -0.6332215980840739 KVVQLDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVVQLDVR 8 1 O95831-3;O95831;O95831-6;O95831-4 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 0 3849430.0 1459800.0 955030.0 1434600.0 False True 1999527.5096116613 912833.61673812 1095777.0265144366 1.0 0.45652466012603454 0.5480179798712813 20.931227699288073 -10.82077522255271 7.33166719316234 1.0241532871858956 0.5022713199986588 0.9752835767335506 0.0373519913748606 0.01325846218321838 0.0003241066440526414 0.032516061942021585 0.012055303378543184 1.510861927433957e-11 10.82077522255271 -0.5218819671872368 KVVVYLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVVVYLQK 8 1 P53634;H0YCY8;P53634-2;P53634-3 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 32939200.0 10149000.0 9177200.0 13613000.0 False True 13305437.28305581 7807997.532445424 12204457.345116632 1.0 0.5868275778045072 0.9172533818680839 23.665512589508104 -9.894023448918258 6.480314414135204 1.0000000168773782 0.7520404798362806 0.42884840169104366 0.13489576963415645 3.294928667246287e-08 5.556224555617518e-09 0.13061227607493323 0.043537422438902074 1.276369891745819e-10 9.894023448918258 -0.24795953704109752 KVVVYLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVVVYLQK 8 1 P53634;H0YCY8;P53634-2;P53634-3 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 33062800.0 11481000.0 5228800.0 16353000.0 False True 11116541.939381672 7316687.107831782 12069658.72051578 1.0 0.6581801380078051 1.0857386034552325 23.406204737993644 -6.693791431577704 1.852766995290144 0.786464715084966 1.0843378625049942 0.38823649463783894 0.14445694283689187 0.4086094806546361 2.722301303620845 0.06230349166532779 0.1614821146981401 2.023990959967905e-07 6.693791431577704 0.29787314742002824 KVVVYLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KVVVYLQK 8 1 P53634;H0YCY8;P53634-2;P53634-3 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 44674000.0 10988000.0 16800000.0 16886000.0 False True 16669599.33040184 13801908.741000887 13548474.69860327 1.0 0.8279688352094409 0.8127654678474308 23.99071609241174 -13.999999999999998 0.34346022938909754 3.0322480624758583 0.8104794906627187 0.9997420493562458 0.0013636640716949173 20.025958155697534 0.1882132026557962 29.59869382715217 0.004640070072278704 1.0000000000000041e-14 13.999999999999998 -2.2217685718131395 KVVVYLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVVVYLQK 8 1 P53634;H0YCY8;P53634-2;P53634-3 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 27083600.0 10149000.0 7339100.0 9595500.0 False True 13901359.566412367 7014834.294841773 7329240.525525773 1.0 0.5046149810980068 0.5272319222095546 23.728722651030996 -10.153619899479757 5.2759767185977555 1.000016574190943 0.5159234516535495 0.9983654785026334 0.009233327545169054 1.800159973841735e-06 2.887785918139597e-07 0.00894043672268808 0.002980043650919455 7.020694905069314e-11 10.153619899479757 -0.48409312253739356 KVVVYLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVVVYLQK 8 1 P53634;H0YCY8;P53634-2;P53634-3 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 26412600.0 11481000.0 8945000.0 5986600.0 False True 9546960.19453848 8896811.509556511 7238370.381089052 1.0 0.9318999271250865 0.7581858762991281 23.18661001342792 -6.955028552887131 0.5006057782509851 1.0034607589593882 0.6791248952106901 0.9995390928272136 0.002185734789726732 0.08152718297011913 0.028075680163850328 0.002560392280563706 0.014330137560295017 1.1091018944596568e-07 6.955028552887131 -0.32433586374869816 KVVVYLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVVVYLQK 8 1 P53634;H0YCY8;P53634-2;P53634-3 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 53008000.0 10988000.0 23474000.0 18546000.0 False True 14224182.605861243 22167651.2646956 15170818.298029773 1.0 1.5584481638727807 1.0665511487302235 23.76184241450419 -10.227697333988479 3.5429110597672397 0.9994328409179041 1.3124996559210664 0.34986106019029173 0.20081611718802772 102327904.67663339 155083965.86013567 636824.4582595705 0.07349116340768451 5.91974045596892e-11 10.227697333988479 0.31306681500316236 KVWIGIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KVWIGIK 7 1 I3L0N3;P46459;P46459-2;I3L2G1;K7EQD6 I3L0N3 NSF Vesicle-fusing ATPase 0 9302800.0 2944000.0 1977600.0 4381200.0 False True 3859612.5097365575 1682549.7886244224 3927875.4514379622 1.0 0.4359374896780161 1.0176864753985535 21.880024583049973 -10.89784389226827 12.267044209876996 1.0152513453954044 0.7268119825382848 0.22722003153049342 0.23749802889949567 0.08823387509898921 0.0007347826380238462 0.20481920883576646 0.07665215922373621 1.2651910403560026e-11 10.89784389226827 -0.2884393628571196 KVWIGIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KVWIGIK 7 1 I3L0N3;P46459;P46459-2;I3L2G1;K7EQD6 I3L0N3 NSF Vesicle-fusing ATPase 0 4755790.0 1539900.0 709190.0 2506700.0 False True 1491016.7173986444 992373.2653769925 1850120.0706119314 1.0 0.6655681682150231 1.240844618992475 20.507865002648355 -6.749121917616215 1.6533049852381076 0.8031430544032067 1.241897817282677 0.6451178050108153 0.1405239378845385 0.30156918335551447 1.6216037690724874 0.0671539917078081 0.16316886261235558 1.7818784781717856e-07 6.749121917616215 0.43875476287947024 KVWIGIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KVWIGIK 7 1 I3L0N3;P46459;P46459-2;I3L2G1;K7EQD6 I3L0N3 NSF Vesicle-fusing ATPase 0 7040500.0 2944000.0 1302600.0 2793900.0 False True 4032476.3586085355 1245046.8248778319 2134038.3621766916 1.0 0.3087548975259097 0.5292128638574517 21.943234644572865 -10.077057863794916 5.283385370235144 1.0000077255463284 0.4189838806911445 0.9025447498692842 0.09000158787651086 8.190248937885098e-06 1.4307138180334502e-06 0.08714482025672068 0.029047887581132484 8.374177002480202e-11 10.077057863794916 -0.5810238448551839 KVWIGIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KVWIGIK 7 1 I3L0N3;P46459;P46459-2;I3L2G1;K7EQD6 I3L0N3 NSF Vesicle-fusing ATPase 0 3666050.0 1539900.0 926950.0 1199200.0 False True 1280495.0791368175 921956.3363648306 1449947.1755256734 1.0 0.7199999058069961 1.1323332663668522 20.28827027808263 -6.723834053685152 1.7454660808431592 0.8303537024740809 1.1318360139456838 0.5305761104156641 0.11777301098336777 0.34791783044899244 2.073520257621559 0.053532656370085446 0.13378749828019457 1.8887128988404237e-07 6.723834053685152 0.30148231147160287 KVWIGIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KVWIGIK 7 1 I3L0N3;P46459;P46459-2;I3L2G1;K7EQD6 I3L0N3 NSF Vesicle-fusing ATPase 0 6815900.0 1530400.0 3110400.0 2175100.0 False True 1981132.9686940322 2937303.5057386565 1779254.118410684 1.0 1.482638243951356 0.898099292943256 20.917894282887083 -6.68747940478081 1.8762078793347856 1.3033097636721283 0.9002239084598558 0.35832254312510037 0.2042295071988579 0.4220833940561213 2.8789090369409247 0.08716180341624752 0.22762917517984155 2.0536224115325252e-07 6.68747940478081 -0.40308585521227247 KWALHILAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KWALHILAR 9 1 O95373 O95373 IPO7 Importin-7 0 12414700.0 2642900.0 0.0 9771800.0 False True 4009472.52187104 0.0 7840399.446867919 1.0 0.0 1.9554690558670191 21.934981020434346 -6.767700219308168 1.583325532643908 0.4247431091207434 1.965508337958718 0.721666284491743 0.4212071789393228 0.27016204994923626 1.3362791922100834 0.2097365367345386 0.5003068540598462 1.7072604539808512e-07 6.767700219308168 1.5407652288379745 KWALHILAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KWALHILAR 9 1 O95373 O95373 IPO7 Importin-7 0 6059420.0 959120.0 2968100.0 2132200.0 False True 1313732.5832434169 2836959.5278058425 1628618.274037419 1.0 2.1594649961423635 1.2396878137989047 20.325240207167262 -10.08224532983371 4.16084842549235 0.9998995933517176 1.6995764037619903 0.4354544682645197 0.37549746293368924 262981843.70090535 358562721.38522094 347790.6829120572 0.13741799563783838 8.274745972052768e-11 10.08224532983371 0.6996768104102726 KWALHILAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KWALHILAR 9 1 O95373 O95373 IPO7 Importin-7 0 17052100.0 2642900.0 9263200.0 5146000.0 False True 3421286.1493475293 8747694.776992781 4209480.802418908 1.0 2.556843945561539 1.2303796346358502 21.706107342526796 -6.607128413003664 2.164482605257409 2.0421525356611223 1.235023932507636 0.04146971302821456 0.6717030913517382 0.6206626667914725 5.505970849950537 0.2566542904629431 0.7460194171157458 2.4709934090418075e-07 6.607128413003664 -0.8071286031534863 KWGLGPK(ub)ASQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KWGLGPKASQK 11 2 O60832;O60832-2;H7C2Q2 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 7196300.0 3014900.0 1509400.0 2672000.0 True False 3902847.4825637983 1425400.5631307636 2185723.417035237 1.0 0.3652206676020072 0.5600330084124695 21.896095654840433 -10.303142288059522 6.042148667621848 1.0000330946716791 0.4626268380072599 0.9102747370667165 0.07953180509713734 3.5458370657175056e-05 4.089524231361712e-06 0.07701106531761287 0.02566877971958521 4.975740379072705e-11 10.303142288059522 -0.5374062566644192 KWYTIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KWYTIFK 7 1 Q9BZL1 Q9BZL1 UBL5 Ubiquitin-like protein 5 0 32250400.0 8976200.0 7349200.0 15925000.0 False True 11767885.12564446 6252728.006957223 14277233.763386633 1.0 0.5313382940262851 1.2132370099597443 23.488351732855058 -6.721735996826021 1.7529233593310243 0.7154039673565715 1.2122895891665149 0.5207539012716537 0.19717375901018447 0.3519601074541702 2.1144572824750085 0.08927800106207694 0.22367714004535272 1.897859259858733e-07 6.721735996826021 0.49688562180994333 KWYTIFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KWYTIFK 7 1 Q9BZL1 Q9BZL1 UBL5 Ubiquitin-like protein 5 0 29015800.0 8776300.0 3213500.0 17026000.0 False True 8497701.16040374 4496667.308181117 12566379.830948574 1.0 0.5291627963023676 1.4787975705127674 23.018641178451446 -6.771927262609699 1.5673664957673272 0.7305980074826549 1.4844929628016568 0.737749830220161 0.19853814471283845 0.26333866527842786 1.2770421226574076 0.09983394559726377 0.23720039341692875 1.6907240772145228e-07 6.771927262609699 0.7538949553190019 KWYTIFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KWYTIFK 7 1 Q9BZL1 Q9BZL1 UBL5 Ubiquitin-like protein 5 0 14821400.0 5173500.0 3708700.0 5939200.0 False True 7848577.733512353 3046853.508794644 4765314.516756163 1.0 0.38820454001302634 0.607156440129136 22.90399981151789 -10.135994110956105 5.24671824900312 1.0000147158238641 0.49768049007073045 0.8752776089593792 0.08938673891748965 1.538719335421578e-05 2.533908594929461e-06 0.08655087052324337 0.028849445933085475 7.311489978146566e-11 10.135994110956105 -0.5023342257531337 KWYTIFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KWYTIFK 7 1 Q9BZL1 Q9BZL1 UBL5 Ubiquitin-like protein 5 0 30167200.0 8976200.0 6509000.0 14682000.0 False True 12294943.712684082 6221410.857615384 11214413.98528157 1.0 0.5060137730599827 0.9121159272744142 23.55156179437795 -10.00945473946728 7.0953995383320745 1.0000000272572356 0.709064850167199 0.406289316382516 0.16579051021173433 7.145395389063169e-08 1.0113695953375997e-08 0.1605259856044279 0.053508657084106404 9.784649213944964e-11 10.00945473946728 -0.2909351770900366 KWYTIFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KWYTIFK 7 1 Q9BZL1 Q9BZL1 UBL5 Ubiquitin-like protein 5 0 23961700.0 8776300.0 7157200.0 8028200.0 False True 7297882.306012371 7118642.743007036 9706859.501797214 1.0 0.9754395103278566 1.3300926343797301 22.799046453885722 -6.890300424461624 1.0206350897777512 0.9810810005896803 1.360772671953809 0.9810887628927386 0.022237682796261402 0.11889849417056551 0.22044197218578188 0.016595246707729397 0.04141598308604681 1.287358709503547e-07 6.890300424461624 0.3796916713641286 KWYTIFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KWYTIFK 7 1 Q9BZL1 Q9BZL1 UBL5 Ubiquitin-like protein 5 0 29223400.0 5173500.0 15943000.0 8106900.0 False True 6697197.734931105 15055758.034976678 6631527.38381847 1.0 2.248068316162918 0.9901943538608524 22.67512613361034 -6.647951807923351 2.0156699073924225 1.8111697863447114 0.9954577981531747 0.18587112773275372 0.532956009154916 0.5135565577747079 3.9969888019718747 0.21460065629811279 0.590330110358122 2.2493041890801566e-07 6.647951807923351 -0.8157119881915367 KYAVLYQPLFDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYAVLYQPLFDK 12 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 23637000.0 9728000.0 3554900.0 10354100.0 False True 9419189.96483799 4974390.108558599 7642050.593658196 1.0 0.5281123034069902 0.8113277916876198 23.16717156504758 -10.311817387150032 5.869070570006431 1.0000301918617058 0.6697200475473049 0.6445452880828988 0.11562223892345888 4.5681684177939914e-05 5.356537043868729e-06 0.11196096594922343 0.037316917150147066 4.877335299804164e-11 10.311817387150032 -0.330310144314401 KYAVLYQPLFDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYAVLYQPLFDK 12 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 21894800.0 5592300.0 7523800.0 8778700.0 False True 7659924.436225041 7191373.638120547 6705351.863001727 1.0 0.9388308850817587 0.875380941265036 22.868898729617865 -6.970665355064829 0.24176751342074995 1.0222894870820811 0.7900831194471679 0.9999871040821959 0.00018261745314618246 0.07608739709347367 0.008253866322572708 0.001497904984438633 0.006166427685698755 1.0698789552457021e-07 6.970665355064829 -0.2322063676349132 KYAVLYQPLFDK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYAVLYQPLFDKR 13 2 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;H0YH88;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 32345800.0 4082100.0 9355700.0 18908000.0 True False 5284358.920220799 8835047.070678744 15466938.012463428 1.0 1.6719241073635447 2.9269279861514717 22.333297028875794 -6.961360172626282 0.4158203249106726 0.9419662460082183 3.703904816249668 0.9998173662830855 0.010792169872108332 0.07921876774776841 0.019362109419380994 0.01619641349745348 0.10459463039359614 1.0930494935947766e-07 6.961360172626282 2.7619385702414494 KYAVLYQPLFDKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYAVLYQPLFDKR 13 2 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;H0YH88;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 17297900.0 7231900.0 7264800.0 2801200.0 False True 9481090.933819214 6180920.157968609 2511358.6950077685 1.0 0.6519207759015537 0.2648807729551152 23.1766216405003 -7.375145323426576 0.334105335303224 1.0606355952014688 1.5701792791001033e-12 0.9996888914903502 0.005295915723100922 0.11243167629695888 0.02883148506938032 0.015327185735343885 0.05606985530700038 4.215554191380638e-08 7.375145323426576 -1.0606355951998987 down KYAVLYQPLFDKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYAVLYQPLFDKR 13 2 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;H0YH88;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 18687500.0 7696100.0 2952200.0 8039200.0 False True 7451791.518132147 4131028.8555196174 5933492.349169606 1.0 0.5543672075993739 0.7962504499397058 22.829155881289676 -10.076796017678328 5.188713381855134 1.000005262954586 0.6753088287689035 0.7061007197171079 0.0987484201795176 6.012095559228198e-06 1.0696790967926404e-06 0.09561429573807041 0.03187091556797748 8.379227508485617e-11 10.076796017678328 -0.3246964341856824 KYAVLYQPLFDKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYAVLYQPLFDKR 13 2 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;H0YH88;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 55745000.0 12695000.0 30490000.0 12560000.0 False True 19259243.128817897 25048821.280542664 10077510.494756427 1.0 1.3006129635001977 0.5232557908611317 24.19904767187075 -6.801829161031893 1.448252154377049 1.1654757118217478 0.5120098916565257 0.8375261744001055 0.12900934117461832 0.21814306526949293 0.9030701107016645 0.07006992819154223 0.16279187949767893 1.5782319787108354e-07 6.801829161031893 -0.6534658201652221 KYAVLYQPLFDKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYAVLYQPLFDKR 13 2 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;H0YH88;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 24542400.0 7231900.0 9981200.0 7329300.0 False True 9905728.864748988 9540197.580585465 5598270.2916717185 1.0 0.9630990016833268 0.5651548076986033 23.239831702023192 -6.924994365247674 0.7867995323934028 1.0073034960556428 0.4929827416901082 0.9954594930654314 0.013265582951548636 0.09532171366327005 0.09103443852805944 0.011743192632230018 0.037047450034009 1.1885176477552923e-07 6.924994365247674 -0.5143207543655346 KYAVLYQPLFDKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYAVLYQPLFDKR 13 2 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;H0YH88;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 15965400.0 7696100.0 5151000.0 3118300.0 False True 6399648.145038542 5123250.540606554 3770322.112609827 1.0 0.8005519091824538 0.5891452197310013 22.609561156723952 -6.970387378703632 0.24875858707600873 1.0681235058243432 0.3153915468772094 0.9999852475852063 0.0006443000344975206 0.07617717266719858 0.008579149036301529 0.004755096722093831 0.02030267438796028 1.070563965692523e-07 6.970387378703632 -0.7527319589471339 KYAVLYQPLFDKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYAVLYQPLFDKR 13 2 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;H0YH88;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 95776000.0 12695000.0 34359000.0 48722000.0 False True 16433927.755861688 32446891.44601159 39855095.92993671 1.0 1.9743844519724365 2.4251716644988357 23.9701739939632 -9.710166742744537 0.2029338395990729 1.0771119421662179e-23 2.835103207540143 0.9994287501857304 0.01421546656826398 1.15933022846649 0.08621016414908704 0.9396958697651459 0.26051153982865966 1.9490961213686899e-10 9.710166742744537 2.835103207540143 KYDAFLASESLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYDAFLASESLIK 13 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 0 26875600.0 6818500.0 9844100.0 10213000.0 False True 8939119.530447923 8375398.652001254 9156256.730013678 1.0 0.9369377625473567 1.0242906696600438 23.09170130771132 -6.712988006247347 1.7842660934678853 0.9613504092766553 1.024106694271058 0.47941060207830244 0.026561968729556115 0.36910243255172853 2.2923416870767412 0.011837908765496563 0.02996862210096467 1.9364754421457007e-07 6.712988006247347 0.06275628499440267 KYDAFLASESLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYDAFLASESLIK 13 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 0 21889100.0 6034500.0 3266600.0 12588000.0 False True 5842938.100618291 4570970.415093964 9290825.168094702 1.0 0.7823068354275858 1.590094744818803 22.478262574950776 -6.8349735496401305 1.3056876526196115 0.8840208794857883 1.6141012036642046 0.9154312898801246 0.09924069847545441 0.17475635530845562 0.5809088257917472 0.05964614165360266 0.13727145051170572 1.4622662299060305e-07 6.8349735496401305 0.7300803241784163 KYDAFLASESLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYDAFLASESLIK 13 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 0 23709300.0 6818500.0 8524500.0 8366300.0 False True 9339483.713034056 8147859.403248171 6390352.24935712 1.0 0.8724100446662946 0.6842297118028946 23.15491136923421 -6.965536324084752 0.34872493701098717 1.0184542339146878 0.531848051415736 0.9999237762702298 0.0011323583179971212 0.0777794299987439 0.014220848140069223 0.0025915636131464193 0.016188389672525446 1.0825891643449151e-07 6.965536324084752 -0.4866061824989518 KYDAFLASESLIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYDAFLASESLIK 13 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 0 10544100.0 6034500.0 2250900.0 2258700.0 False True 5017954.123677585 2238773.95493133 2730983.7269511656 1.0 0.4461527347106484 0.544242466080911 22.258667850385052 -10.079429702374208 5.370775237622911 1.0000057404385925 0.4951976003955749 0.972461643241303 0.04004496514536851 2.752527390278914e-06 4.717866882330172e-07 0.03877381141505441 0.012924456925420097 8.328567264829007e-11 10.079429702374208 -0.5048081400430176 KYDAFLASESLIK(ub)QIPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYDAFLASESLIKQIPR 17 2 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 21979500.0 8818400.0 9056000.0 4105100.0 True False 7332890.321358594 9007213.53052474 4963457.43016214 1.0 1.228330594866437 0.6768759946817997 22.805950530356 -6.7942629686937 1.4792843303859828 1.126910420605395 0.6703047418749786 0.8148329814003425 0.09735186794220956 0.22905471671346544 0.9900571622531296 0.051788666185581436 0.12088304003401786 1.6059685320843884e-07 6.7942629686937 -0.45660567873041646 KYDVLFALFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYDVLFALFSK 11 1 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 0 2699560.0 685220.0 1284300.0 730040.0 False True 898330.0556799199 1092687.4461621915 654502.4638381662 1.0 1.2163540997580984 0.7285768295293118 19.77688607776304 -6.786124379896555 1.511725216459812 1.1215321093321597 0.7239246605089648 0.7885420056427525 0.09176532689354615 0.2411776510676323 1.088866765298084 0.04779065508138722 0.1122163517407621 1.6363478119974786e-07 6.786124379896555 -0.397607448823195 KYEAIITVVKPSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYEAIITVVKPSTR 14 2 Q9UJA5;Q9UJA5-2;Q9UJA5-3 Q9UJA5 TRMT6 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 0 8067500.0 1949200.0 2463300.0 3655000.0 False True 2555420.076079653 2095785.2418681937 3276815.6612356775 1.0 0.8201333555629731 1.2823001947541788 21.285129039297914 -6.801213790544646 1.451420743499145 0.9009115930123422 1.2888381224789083 0.8355501167548264 0.07713772045535063 0.21903847187033465 0.9109223353223916 0.04181169748594196 0.09714715501285512 1.580469828402569e-07 6.801213790544646 0.38792652946656603 KYEAIITVVKPSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYEAIITVVKPSTR 14 2 Q9UJA5;Q9UJA5-2;Q9UJA5-3 Q9UJA5 TRMT6 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 0 6380300.0 1949200.0 2011200.0 2419900.0 False True 2669871.9151493744 1922338.5338509844 1848369.459404909 1.0 0.7200115192580064 0.6923064169921036 21.348339100820805 -13.999999999999998 0.3270105187175524 3.993566817355124 0.6872264532135451 0.9997086018240294 0.0023724185582896383 18.573608582399093 0.18270330130062407 38.18138743997257 0.008978400007060867 1.0000000000000041e-14 13.999999999999998 -3.3063403641415787 KYEAIQLTFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYEAIQLTFK 10 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 0 11728200.0 4385000.0 3812900.0 3530300.0 False True 5748777.464400406 3244030.182567794 3165018.421028817 1.0 0.5642991405836483 0.5505550424639591 22.454823754325055 KYEAIQLTFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYEAIQLTFK 10 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 0 11517600.0 3316700.0 1892200.0 6308700.0 False True 3211413.173969789 2647765.3276926456 4656262.213056811 1.0 0.82448603909151 1.449910665746249 21.614776860575994 -6.8317897385994275 1.3199633243150715 0.9063291211352255 1.4673558254141132 0.9093959645553761 0.07928248561417651 0.17861205240414008 0.6079951086879882 0.047151979143986084 0.10850384602318834 1.473025487405602e-07 6.8317897385994275 0.5610267042788878 KYEAIQLTFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYEAIQLTFK 10 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 0 20920600.0 4390300.0 8913600.0 7616700.0 False True 6660406.07392274 7322898.437725334 6111255.9064817885 1.0 1.099467263174302 0.9175500470472783 22.66717870802842 -6.758269975662238 1.619277172061424 1.0579012703777697 0.9169484790206448 0.6837480410889596 0.041826088097119636 0.28583509313386246 1.476793004530577 0.020385309488362594 0.049067412822233876 1.7447372139153304e-07 6.758269975662238 -0.1409527913571249 KYEAIQLTFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYEAIQLTFK 10 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 0 14108200.0 4385000.0 4436700.0 5286500.0 False True 6006253.0001693 4240671.923795086 4037937.578885101 1.0 0.7060428396332212 0.6722889593181111 22.518033815847946 -13.999999999999998 0.30547090725385023 3.76747448329164 0.6644452711831571 0.9996619974742993 0.0027057857450587977 16.95383133387468 0.17569994762169353 29.747278625237247 0.011918602445377329 1.0000000000000041e-14 13.999999999999998 -3.103029212108483 KYEAIQLTFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYEAIQLTFK 10 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 0 7016300.0 3316700.0 2368800.0 1330800.0 False True 2757983.0047230846 2356038.8042300115 1609064.1270760216 1.0 0.8542615383036306 0.5834206100329395 21.39518213601027 -6.961455496199963 0.41441665473017725 1.0127161392053223 0.4148422575561235 0.9998204161805195 0.0023130554494029546 0.07918530920870132 0.01924053326812566 0.0034930553600152543 0.022581918683073087 1.0928096057896563e-07 6.961455496199963 -0.5978738816491989 KYEAIQLTFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYEAIQLTFK 10 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 0 19438700.0 4390300.0 9351800.0 5696600.0 False True 5683329.895751047 8831364.10910712 4659877.252051992 1.0 1.5539066482326842 0.8199202470255677 22.43830503012087 -6.704853839583515 1.813497077105301 1.3423152845182642 0.8218931407070637 0.4405658269072369 0.2336118626211356 0.3855644254287773 2.468439062955536 0.10263853260020579 0.26239534692347677 1.9730866603819416e-07 6.704853839583515 -0.5204221438112006 KYEAIQLTFK(ub)QVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYEAIQLTFKQVSK 14 2 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 33813100.0 12660000.0 17128000.0 4025100.0 True False 16597382.599614393 14572569.164421083 3608621.263485561 1.0 0.8780040513592575 0.21742110491381939 23.984452411308663 -6.938044263841248 0.677514464552923 1.007725544728098 0.04908540214372431 0.9978963416812019 0.015767844856035818 0.08867033067275903 0.05875851032057489 0.01513023802151518 0.057362218627154474 1.1533357024013317e-07 6.938044263841248 -0.9586401425843736 down KYEAIQLTFK(ub)QVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYEAIQLTFKQVSK 14 2 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 44588400.0 18050000.0 20835000.0 5703400.0 True False 17477012.630070474 29154524.153089654 4209508.441667575 1.0 1.6681640489820995 0.24085972418563167 24.058955268265887 -6.779351182233153 1.5380579472087086 1.3786204558053803 0.22969191541877737 0.7652932006182405 0.2824864796603818 0.2515289635326192 1.1751885036581158 0.14465728028884328 0.3415645541813808 1.662068113718119e-07 6.779351182233153 -1.148928540386603 KYEDICPSTHNMDVPNIK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYEDICPSTHNMDVPNIKR 19 2 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 79710000.0 17682000.0 37074000.0 24954000.0 True False 23181273.232731555 31542703.713320144 22371999.45567034 1.0 1.3606976371247113 0.9650893301271074 24.466456472838114 -6.666812520777442 1.948944171999987 1.2308661347470926 0.9667191502126199 0.2648578206489912 0.15333120128907415 0.4684983862937647 3.4277228663694785 0.06341060270716246 0.17010771204117894 2.1537112629365175e-07 6.666812520777442 -0.2641469845344727 KYEDICPSTHNMDVPNIK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 2 KYEDICPSTHNMDVPNIKR 19 2 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 46777300.0 18217300.0 14661100.0 13898900.0 True False 17639001.783145867 20515353.686626457 10258361.131937683 1.0 1.1630677256481121 0.5815726568914793 24.07226558319916 -6.831853902954559 1.3197332216921143 1.087024261890282 0.5653381023461385 0.9095093246879058 0.07367170741416836 0.1785346650193245 0.6075054452904836 0.04382304226634267 0.10084045161820118 1.4728078729695162e-07 6.831853902954559 -0.5216861595441434 KYEDICPSTHNMDVPNIK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 2 KYEDICPSTHNMDVPNIKR 19 2 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 399227000.0 66100000.0 89734000.0 243393000.0 True False 100278532.55729537 73720266.60505791 195286266.86705843 1.0 0.7351550199733621 1.94743841864139 26.5794375486183 -6.8494643626441585 1.2376617980339528 0.8587318094620882 1.99540580884089 0.9395260149106908 0.127975737678521 0.1580450104582631 0.46613939220786904 0.08092253523452339 0.18719791248272682 1.414280773423117e-07 6.8494643626441585 1.1366739993788018 KYEDICPSTHNMDVPNIK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 2 KYEDICPSTHNMDVPNIKR 19 2 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 90145900.0 22482900.0 36524700.0 31138300.0 True False 30795435.707527068 34910917.9829689 23784074.85341871 1.0 1.133639358589621 0.7723246743219604 24.876213204414984 -6.8065587145173785 1.4288297107454795 1.0731353090684292 0.7664823618553941 0.8506734415116018 0.057640381493313526 0.21153640189635406 0.8517643296896801 0.03172528412539099 0.07351216762788794 1.5611379653855135e-07 6.8065587145173785 -0.30665294721303515 KYEDICPSTHNMDVPNIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYEDICPSTHNMDVPNIKR 19 2 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 44873000.0 14171000.0 14871000.0 15831000.0 True False 11783814.381744172 14790886.9713376 19141188.905726273 1.0 1.25518669016478 1.624362730575624 23.490303274592176 -6.96585195032179 0.34312222309611234 0.9613784619393511 1.9304978863242719 0.9999296390532523 0.002149933002325531 0.07767309237968194 0.013847522769774408 0.005163208156815411 0.03188187056275884 1.08180267171251e-07 6.96585195032179 0.9691194243849208 KYEDICPSTHNMDVPNIK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 2 KYEDICPSTHNMDVPNIKR 19 2 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 394185000.0 66100000.0 80828000.0 247257000.0 True False 85567753.02579433 76329850.74647775 202258763.07106355 1.0 0.8920399104493042 2.363726473103633 26.35056387071075 -6.88924985532282 1.0268358165504776 0.9194963204987022 2.488448384930947 0.9804128638394173 0.09373632674972773 0.11975285519875675 0.22543251614968918 0.06962451946870857 0.1731087255727538 1.290476631842837e-07 6.88924985532282 1.5689520644322448 up KYEEIDNAPEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYEEIDNAPEER 12 1 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 10868660.0 2547100.0 939160.0 7382400.0 False True 2466243.7047120524 1314171.4856547003 5448727.972747247 1.0 0.5328635946008982 2.209322607630707 21.2338839376811 -6.832358212553939 1.317435516637629 0.7507804847366715 2.2566158696684346 0.9104935003781189 0.21134251077283464 0.17791852654092075 0.6031126330421553 0.12592663463471193 0.2897751327950069 1.471098617846514e-07 6.832358212553939 1.5058353849317632 up KYELGRPAANTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYELGRPAANTK 12 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 8656430.0 244730.0 4700400.0 3711300.0 False True 320843.39996869164 3999118.642015699 3327290.277303415 1.0 12.4643942883224 10.370449501620095 18.291509780458576 -9.274995634448668 8.671539894905393 1.0000288392297119 11.417421894981487 0.9705892114226323 0.8548493796964559 0.0 0.0 0.8277043403465733 0.2759014508933244 5.308897807366024e-10 9.274995634448668 10.417393055751775 KYELGRPAANTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYELGRPAANTK 12 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 45433360.0 960160.0 43413000.0 1060200.0 False True 1456632.9170985266 35665610.96268283 850651.0052978323 1.0 24.484968411756967 0.5839844722116041 20.474205922082678 -9.40326625810484 5.553313941428172e-10 8.671994027304564 14.090063207385118 0.0 11.489925377881212 0.0 0.7891619247044197 536530766.1528426 536530768.52164114 3.951243022204015e-10 9.40326625810484 5.418069180080554 KYELGRPAANTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYELGRPAANTK 12 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 10571030.0 244730.0 5380800.0 4945500.0 False True 335213.2945795745 5143058.464073883 3777474.7557696537 1.0 15.342644660094173 11.268869155405588 18.354719841981467 -9.583329156984416 10.847557677483753 1.0000000357798116 13.305756907749881 0.9240489531150898 1.6631118855226759 0.0 0.0 1.6103010149051094 0.5367670529590782 2.610182316115839e-10 9.583329156984416 12.30575687197007 KYELGRPAANTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYELGRPAANTK 12 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 3867160.0 960160.0 1011300.0 1895700.0 False True 1242946.0475831556 955020.2659958526 1550702.051524587 1.0 0.768352148391992 1.2476020616822807 20.245332244175128 -6.775307424819661 1.5544724935571639 0.8680330481872991 1.2508331700127213 0.750314747999013 0.09778293385728647 0.2579406740835708 1.2307730527541252 0.04956556601960477 0.11740554543248664 1.677616060599132e-07 6.775307424819661 0.3828001218254222 KYELGRPAANTK(ub)IGPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYELGRPAANTKIGPR 16 3 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 10261100.0 2061200.0 3108100.0 5091800.0 True False 2702253.160689193 2644383.59527891 4564949.3799944855 1.0 0.978584698779472 1.6893122548259778 21.365731409258625 -6.899955301093637 0.9615783611848195 0.9704134094440381 1.7638398226193448 0.9865429452088602 0.038294068086139096 0.11143799097767815 0.17761878670739026 0.02987158226304082 0.07770095543390385 1.2590549908871937e-07 6.899955301093637 0.7934264131753067 KYELGRPAANTK(ub)IGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYELGRPAANTKIGPR 16 3 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 24554900.0 4729600.0 4490300.0 15335000.0 True False 4579461.4368521515 6283300.206605157 11318303.459861163 1.0 1.372060949360062 2.4715359253338716 22.12674651086278 -6.951789624831965 0.5388430008311211 0.9836885409854972 2.910581175288357 0.9993343186013144 0.016118773704459383 0.08277506804814375 0.03304976323590599 0.017757121215806342 0.09103540306005324 1.1174043949067177e-07 6.951789624831965 1.9268926343028596 up KYELGRPAANTK(ub)IGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYELGRPAANTKIGPR 16 3 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 12544900.0 2061200.0 3307300.0 7176400.0 True False 2823281.3418355654 3161172.550221444 5481482.122597375 1.0 1.1196803178553214 1.9415288307872187 21.428941470781517 -6.933050560937667 0.7213129775657118 0.9888066353301098 2.1241510931484306 0.9971045800076951 0.022518786554559782 0.09108438634548599 0.07014529473256002 0.020901532571669795 0.07315570158085771 1.1666737839873573e-07 6.933050560937667 1.135344457818321 KYEQGFITDPVVLSPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYEQGFITDPVVLSPK 16 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 13809700.0 3821900.0 1869200.0 8118600.0 False True 3700575.8765022913 2615581.3077492253 5992095.10722067 1.0 0.7068038583825551 1.6192331429464637 21.81931836696463 -6.820240936406616 1.370954380177502 0.8420103160293718 1.6392357135822482 0.8849115355950912 0.12902987350095818 0.1931682997984709 0.713352639019864 0.07396054003051403 0.1704459726504097 1.5127217929824953e-07 6.820240936406616 0.7972253975528764 KYEQGFITDPVVLSPK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYEQGFITDPVVLSPKDR 18 2 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 21524100.0 5763300.0 5150800.0 10610000.0 True False 7460705.4616272235 4864153.452082911 8679088.867793355 1.0 0.651969639747983 1.1633067291602202 22.830880623111817 -6.723417983549231 1.746807544996904 0.7890437059029615 1.162679305969599 0.528707040544057 0.1463941712156228 0.3487100543073847 2.0811927598070548 0.06649434396409573 0.16627154593247376 1.8905232225170364e-07 6.723417983549231 0.37363560006663754 KYETVIMPVFGIATPFHIATIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYETVIMPVFGIATPFHIATIK 22 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 25182800.0 9960900.0 6939200.0 8282700.0 False True 9644696.681820992 9710058.747449951 6113212.394326187 1.0 1.0067769954603298 0.633841850708359 23.201304436679568 -6.902761919202323 0.9436353795678053 1.014352281162595 0.592423138346106 0.9878911854758307 0.01917205064333653 0.10940096275711333 0.16617305262558438 0.01515509387276448 0.040006768262163137 1.2509446117391646e-07 6.902761919202323 -0.42192914281648886 KYETVIMPVFGIATPFHIATIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYETVIMPVFGIATPFHIATIK 22 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 54142300.0 9494300.0 16217000.0 28431000.0 False True 14403547.226304533 13322949.646000687 22811600.388250045 1.0 0.9249769821748909 1.583748782840818 23.779920818627996 -6.878575755701215 1.0876714125420053 0.9543183806467926 1.6291863162025761 0.9725201118040824 0.048813156221347534 0.12890106814493674 0.27995083725912084 0.03461315152662203 0.08341164133963418 1.3225869838178606e-07 6.878575755701215 0.6748679355557835 KYETVIMPVFGIATPFHIATIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYETVIMPVFGIATPFHIATIK 22 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 19131920.0 3166200.0 2951620.0 13014100.0 False True 4336829.703337745 2821207.668697914 9940437.613802815 1.0 0.6505230460229126 2.2920977519943606 22.04820936254276 -6.85104941804789 1.230023341121406 0.8133282510074004 2.359059126691425 0.9418181949180178 0.17030296933639666 0.1563060001805888 0.45454883220158554 0.10831140898513716 0.2508116843595785 1.4091284456152032e-07 6.85104941804789 1.5457308756840247 up KYETVIMPVFGIATPFHIATIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYETVIMPVFGIATPFHIATIK 22 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 29619300.0 9960900.0 7236000.0 12422400.0 False True 8282929.692690381 7197018.231766461 15019866.40531196 1.0 0.868897660463999 1.813351913220617 22.981709712113844 -6.87178890885367 1.1245344637133123 0.9249803945827503 1.87059060540551 0.966438924948898 0.07653260161297101 0.13515396305697458 0.3183359312388631 0.052756496831089884 0.12531116627168895 1.3434177778395336e-07 6.87178890885367 0.9456102108227596 KYETVIMPVFGIATPFHIATIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYETVIMPVFGIATPFHIATIK 22 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 33831200.0 9494300.0 14548900.0 9788000.0 False True 12290558.510632364 13739240.925489036 8006684.433361122 1.0 1.1178695348631587 0.651450007453662 23.551047140720446 -6.839722349727203 1.2835958536761143 1.0627085517432233 0.6361850694753526 0.9239872512123496 0.05459648862161988 0.16912541644960488 0.5413949277152157 0.03335280117333647 0.0768365236949298 1.4463641551843903e-07 6.839722349727203 -0.42652348226787073 KYGGPPPDSVYSGVQPGIGTEVFVGK(ub)IPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYGGPPPDSVYSGVQPGIGTEVFVGKIPR 29 2 O43390;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 8627800.0 2705500.0 2425900.0 3496400.0 True False 2619615.383415824 3394574.52090138 2580587.9502483597 1.0 1.2958293581537361 0.9851018460898735 21.32092357758644 -6.657349065074217 1.9826983483171414 1.1908437651213444 0.9864141778672475 0.2241883788556528 0.12603932338593773 0.4907911649451828 3.706164659527453 0.051414173084652445 0.13964807918529168 2.2011565677965283e-07 6.657349065074217 -0.20442958725409688 KYGGPPPDSVYSGVQPGIGTEVFVGK(ub)IPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYGGPPPDSVYSGVQPGIGTEVFVGKIPR 29 2 O43390;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 7786700.0 2705500.0 2782900.0 2298300.0 True False 2249743.1239721123 2767907.965337602 2778863.9038614533 1.0 1.2303217802264579 1.2351916422151936 21.101328853020718 -12.076623933153229 0.5847986729365506 1.2568977413498185e-14 1.2346381876706298 0.9999615741434852 0.000680241890679579 8.21504154004689 0.2913428222810545 10.344929261325577 0.0008652744262744463 8.382548345291132e-13 12.076623933153229 1.2346381876706172 KYGGPPPDSVYSGVQPGIGTEVFVGK(ub)IPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYGGPPPDSVYSGVQPGIGTEVFVGKIPR 29 2 O43390;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 29208000.0 6093500.0 7696500.0 15418000.0 True False 7888155.870842324 7268183.00923276 12612082.202039411 1.0 0.9214045878706298 1.5988632081496446 22.91125662913704 -6.878000590318747 1.090841307876248 0.952458930622939 1.645079801179205 0.972038716911287 0.05058932018929397 0.12941819333184745 0.28308682953796876 0.03578552010583831 0.08611909850771973 1.324339735072543e-07 6.878000590318747 0.692620870556266 KYGLNMCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYGLNMCR 8 1 A0A2R8Y851;P62273;P62273-2;A0A2R8Y6P7;A0A087WTT6 A0A2R8Y851 RPS29 40S ribosomal protein S29 0 18074000.0 3682100.0 9025300.0 5366600.0 False True 4827268.757507126 7678760.420343852 4811315.712062214 1.0 1.590704973366612 0.9966952232729733 22.202775720185617 -10.287731794459877 3.9399733350178603 0.9995417234155878 1.29370009835513 0.24582749964537254 0.24250346511114187 85970484.01485318 269.24702783033985 357802.9509118074 0.08301538630471704 5.1554693058654983e-11 10.287731794459877 0.2941583749395421 KYGLNMCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYGLNMCR 8 1 A0A2R8Y851;P62273;P62273-2;A0A2R8Y6P7;A0A087WTT6 A0A2R8Y851 RPS29 40S ribosomal protein S29 0 23583000.0 3542600.0 17964000.0 2076400.0 False True 5374383.1987515045 14758183.846627388 1665998.6298815513 1.0 2.7460237390694036 0.30998880583516464 22.357667759902835 -6.714302945242085 1.7796876463903222 2.0686568241034253 0.3149123507664846 0.485582031429423 0.7352905362819442 0.3664977644969381 2.265295551519702 0.3284524544555944 0.8301545426526206 1.9306211285354128e-07 6.714302945242085 -1.7537444733369407 KYGLNMCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYGLNMCR 8 1 A0A2R8Y851;P62273;P62273-2;A0A2R8Y6P7;A0A087WTT6 A0A2R8Y851 RPS29 40S ribosomal protein S29 0 13002900.0 3682100.0 3237800.0 6083000.0 False True 5043471.875011035 3094743.29002721 4646320.683317521 1.0 0.6136136706463617 0.921254405390603 22.26598578170851 -9.881203142186562 6.3345593385857955 1.0000000190309766 0.7674340380184502 0.432456548328932 0.12559380403649828 3.374287042056107e-08 6.00726673834339e-09 0.12160568691531813 0.04053522595166605 1.314609776780203e-10 9.881203142186562 -0.23256598101252635 KYGLNMCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYGLNMCR 8 1 A0A2R8Y851;P62273;P62273-2;A0A2R8Y6P7;A0A087WTT6 A0A2R8Y851 RPS29 40S ribosomal protein S29 0 16311100.0 3542600.0 5068200.0 7700300.0 False True 4585965.535085914 4786150.214694145 6298924.411750168 1.0 1.043651588324569 1.373521969050769 22.128794081995284 -6.931171411436424 0.7371054325086415 0.9951955928521945 1.4433099760258379 0.9967636913016981 0.009485948839110555 0.0920337527368863 0.074731400166877 0.008703230062770125 0.029657548075475416 1.1717328037313266e-07 6.931171411436424 0.4481143831736434 KYIIYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYIIYAK 7 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 9092600.0 3266100.0 2292400.0 3534100.0 False True 4281888.7289573895 1950382.855705214 3168425.233480989 1.0 0.45549592228196895 0.7399597313339057 22.029815875027243 -10.587952883232283 7.872427763372186 1.0002294609724747 0.5977278268079373 0.7272526061739826 0.11613186374429194 0.00046796253405392325 2.449318307412639e-05 0.11250638389469296 0.03748139785380597 2.5825403561876586e-11 10.587952883232283 -0.4025016341645373 KYIIYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYIIYAK 7 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 6840810.0 1655900.0 517510.0 4667400.0 False True 1603334.3608938318 724154.4417789977 3444867.921001374 1.0 0.4516552875317247 2.148564893900807 20.612643887207042 -6.819717924067324 1.373091929586965 0.7043603728338368 2.185387224803487 0.8837330646911736 0.2410923651816791 0.1938489688416303 0.7182231068735244 0.13798080136017898 0.3180480397373676 1.5145446315966178e-07 6.819717924067324 1.4810268519696501 up KYIIYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYIIYAK 7 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 9844300.0 2491700.0 4732100.0 2620500.0 False True 3780091.0676703914 3887619.782933946 2102557.026394046 1.0 1.0284460647478058 0.5562186171588235 21.849989560726566 -6.892578516227564 1.0069805126688165 1.0238271634291964 0.5134861569478828 0.9824988266667434 0.028603837885011224 0.11707690509575917 0.20981520722982475 0.02156655796904491 0.05429096526756688 1.2806235492968932e-07 6.892578516227564 -0.5103410064813136 KYIIYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYIIYAK 7 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 7463000.0 3266100.0 2054300.0 2142600.0 False True 4473665.433033736 1963534.2333383458 1636562.0082321435 1.0 0.4389094944024033 0.36582127848624973 22.093025936550134 -13.999999999999998 0.2873185932965277 5.762608808379415 0.34536088797976017 0.9996214651821325 0.005511938816242219 15.808296471370033 0.1699275228058707 44.431402937319056 0.027942147000914033 1.0000000000000041e-14 13.999999999999998 -5.417247920399655 KYIIYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYIIYAK 7 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 5652900.0 1655900.0 2870700.0 1126300.0 False True 1376954.218808139 2855234.9693106622 1361804.1225771909 1.0 2.073587436902652 0.9889973856617675 20.39304916264132 -6.648482372537657 2.0136886383403265 1.6974700582640794 0.993527105912013 0.1880515294100007 0.45838676563226055 0.512237263891146 3.979473043829366 0.18471333449776187 0.5077708570031488 2.2465579590803133e-07 6.648482372537657 -0.7039429523520664 KYIIYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYIIYAK 7 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 9907000.0 2491700.0 3755700.0 3659600.0 False True 3225554.7687499505 3546691.993474364 2993590.350666974 1.0 1.099560307527771 0.9280854194973496 21.621115882819016 -6.74932075712277 1.6526128773472084 1.0585908861418303 0.9277674072274342 0.6459463991548522 0.04183432191002425 0.30122764125642193 1.6184804121549945 0.019999902960899638 0.048584187029519096 1.781062840959104e-07 6.74932075712277 -0.13082347891439605 KYIVAYHAAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYIVAYHAAGK 11 1 Q96PZ0;Q96PZ0-2;E7EUH7;H0Y863 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 4425400.0 1643500.0 1315100.0 1466800.0 False True 2154644.415676638 1118892.2062196487 1315029.6065391244 1.0 0.5192932059131786 0.6103232612171677 21.03901836807327 -10.100171147073972 7.373555848950085 1.0000001008654067 0.5648082335651732 0.9682278136676705 0.03716286445868451 6.160721083494919e-08 7.526247730580853e-09 0.03598279709722895 0.011994262928820712 7.940152669678552e-11 10.100171147073972 -0.4351918673002335 KYIVAYHAAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYIVAYHAAGK 11 1 Q96PZ0;Q96PZ0-2;E7EUH7;H0Y863 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 3488590.0 1161100.0 514890.0 1812600.0 False True 1124241.5160540082 720488.2621158794 1337825.683165592 1.0 0.6408660877822159 1.1899806794729 20.10052056625706 -6.730232162227903 1.7222361326692657 0.7839302558642677 1.1896761504610391 0.560380959172575 0.15096900935838184 0.3358158916839462 1.9514580227787688 0.0694607386306046 0.1723265347282187 1.8610919806406414e-07 6.730232162227903 0.40574589459677146 KYIVAYHAAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYIVAYHAAGK 11 1 Q96PZ0;Q96PZ0-2;E7EUH7;H0Y863 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 3789400.0 1643500.0 1103900.0 1042000.0 False True 2251146.3639174993 1055126.047890862 795901.0606636298 1.0 0.46870610672098023 0.3535536708855232 21.10222842959616 -13.999999999999902 0.21488684004518374 4.1360674312548396 0.2888572370144931 0.9994933114881615 0.006337582169632613 12.865556101893828 0.14689247493590943 17.075942267329005 0.06594820015910677 1.000000000000225e-14 13.999999999999902 -3.8472101942403465 KYIVAYHAAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYIVAYHAAGK 11 1 Q96PZ0;Q96PZ0-2;E7EUH7;H0Y863 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 2820250.0 1161100.0 1093000.0 566150.0 False True 965506.0954514968 1087111.7920564858 684529.3474181624 1.0 1.1259502111668418 0.7089850086322427 19.880925841691337 -6.825701358470297 1.3470930808992845 1.0675233910446082 0.6987249596944978 0.8969836157063908 0.05604467601001442 0.1861763717965837 0.662245039538942 0.032680214045427834 0.07523057631541204 1.4938212789958225e-07 6.825701358470297 -0.3687984313501105 KYIVAYHAAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYIVAYHAAGK 11 1 Q96PZ0;Q96PZ0-2;E7EUH7;H0Y863 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 9751700.0 2030900.0 2853100.0 4867700.0 False True 2629040.085023989 2694322.4769235365 3981828.5468197707 1.0 1.0248312653243368 1.5145560425273767 21.32610470824645 -6.917424195805904 0.8435981592129692 0.9881593003085888 1.5890350455511693 0.9934352660446231 0.019196645870565687 0.09971124612361319 0.11363850563551378 0.016318141973103217 0.04774002640187012 1.2094162628172254e-07 6.917424195805904 0.6008757452425805 KYPIDLAGLLQYVANQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYPIDLAGLLQYVANQLK 18 1 Q8NI27;A0A0C4DG98 Q8NI27 THOC2 THO complex subunit 2 0 1739440000.0 673800000.0 608270000.0 457370000.0 False True 1022203861.3782995 499719466.064798 366970619.027608 1.0 0.4888647802513639 0.3589994451134231 29.929035800232366 -13.999999999999998 0.19239083277971555 3.763004180851447 0.2680411884634982 0.9994882704951027 0.00625907663876452 12.390615879605628 0.13909746890483515 12.844783251536711 0.08764106269412053 1.0000000000000041e-14 13.999999999999998 -3.494962992387949 KYPYLWLCYNGEIYNHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYPYLWLCYNGEIYNHK 17 1 P08243-2;P08243;F8WEJ5;C9J057;C9JT45;C9JM09;C9JLN6 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 28099600.0 8187300.0 10777000.0 9135300.0 False True 10598621.24581066 10177250.476255618 7472769.136093566 1.0 0.9602428693523134 0.7050699296427206 23.337373263791854 -6.9344256864659926 0.7095220129510739 1.003317051060837 0.6462458793686615 0.9973388366188708 0.006740927365475257 0.09040406360421119 0.06689340297988945 0.006311867272586982 0.0225533780520863 1.162985536196439e-07 6.9344256864659926 -0.3570711716921754 KYQLAVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYQLAVTK 8 1 Q8NDV3-2;Q8NDV3-3;Q8NDV3 Q8NDV3-2 SMC1B Structural maintenance of chromosomes protein 1B 0 6001400.0 1902100.0 1631300.0 2468000.0 False True 2493671.5199626004 1387916.398757596 2212635.034727676 1.0 0.5565754702040354 0.8873001183254724 21.249840007333884 -9.88137653410763 6.99891429564621 1.0000000041209012 0.7219377942647521 0.48520418860202463 0.135017772209847 8.674249923256569e-09 1.391669234644944e-09 0.1307303977507218 0.043576798600895875 1.3140850240440352e-10 9.88137653410763 -0.27806220985614905 KYQLAVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYQLAVTK 8 1 Q8NDV3-2;Q8NDV3-3;Q8NDV3 Q8NDV3-2 SMC1B Structural maintenance of chromosomes protein 1B 0 5039700.0 1902100.0 1227700.0 1909900.0 False True 2605357.77231973 1173456.1545390089 1458820.9556252076 1.0 0.4504011568031978 0.5599311430945312 21.313050068856775 -9.946591419509218 6.316687312618546 1.0000001097505662 0.5051661499490233 0.9645565309758823 0.044715429658069364 6.914269148846495e-08 1.1439103740835193e-08 0.04329553827320046 0.014431842865335963 1.1308593170350441e-10 9.946591419509218 -0.4948339598015429 KYSQFINFPIYVWSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYSQFINFPIYVWSSK 16 1 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 374476000.0 82490000.0 99036000.0 192950000.0 False True 125143360.82679708 81362252.02820028 154813347.92701066 1.0 0.6501523651806712 1.237087983766697 26.89900651351845 -6.745237095576626 1.6673205273746199 0.7931150090586198 1.2378538579301737 0.6282774950811786 0.14698719249889433 0.30843276431240035 1.6853944094668816 0.06968465193065576 0.1700401828140887 1.7978891206218158e-07 6.745237095576626 0.4447388488715539 KYSQFINFPIYVWSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYSQFINFPIYVWSSK 16 1 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 25218900.0 6166000.0 9711500.0 9341400.0 False True 5127302.200115339 9659182.221918175 11294643.550246429 1.0 1.8838722284988179 2.202843349079825 22.289768501145442 -10.346633172795135 0.22711949425337744 3.732114887783291e-17 2.4123489233712845 0.9992423355278696 0.014004800903713104 1.9541064991877934 0.11093663354054992 1.3059367223147986 0.16406060856809984 4.5015992232121e-11 10.346633172795135 2.4123489233712845 KYSQFINFPIYVWSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYSQFINFPIYVWSSK 16 1 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 471220000.0 82490000.0 174000000.0 214730000.0 False True 106784931.12099496 164316747.0417071 175651343.31585962 1.0 1.5387634314763428 1.6449075864162341 26.6701328356109 -11.599359051130774 0.2787305657705898 2.511008904638061e-11 1.6814673228012649 0.999353547119624 0.00717859339329601 4.15533014605605 0.1527236174568459 2.5184343895297303 0.042140883174872086 2.515596309169877e-12 11.599359051130774 1.6814673227761547 KYTLPPGVDPTQVSSSLSPEGTLTVEAPMPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYTLPPGVDPTQVSSSLSPEGTLTVEAPMPK 31 1 P04792 P04792 HSPB1 Heat shock protein beta-1 0 55604800.0 18979000.0 8977800.0 27648000.0 False True 18376522.033579353 12562682.358608512 20406159.377779037 1.0 0.6836267676578173 1.1104473055614623 24.13136041018012 -6.708173136101279 1.8016013445683103 0.8051391110754645 1.1093961650669517 0.4564534808817825 0.13335674258559038 0.3787702494935886 2.3953285256450534 0.05892939692463499 0.15004742353531222 1.9580639149408376e-07 6.708173136101279 0.30425705399148717 KYTLPPGVDPTQVSSSLSPEGTLTVEAPMPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYTLPPGVDPTQVSSSLSPEGTLTVEAPMPK 31 1 P04792 P04792 HSPB1 Heat shock protein beta-1 0 73159800.0 7941800.0 51232000.0 13986000.0 False True 12048291.223351395 42089249.32255703 11221660.969718438 1.0 3.4933791474912024 0.9313902495956585 23.522325211628758 -6.652335708794545 1.9999550460570483 2.6149216666472284 0.9420920704527177 0.203709686867538 1.0635849874907102 0.5028029892897194 3.8574160051777184 0.43087830921174824 1.1783940702022508 2.226713238812389e-07 6.652335708794545 -1.6728295961945108 KYTLPPGVDPTQVSSSLSPEGTLTVEAPMPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYTLPPGVDPTQVSSSLSPEGTLTVEAPMPK 31 1 P04792 P04792 HSPB1 Heat shock protein beta-1 0 8042800.0 3686600.0 1555400.0 2800800.0 False True 5049635.646618955 1486677.2849800237 2139308.7242866526 1.0 0.29441278322237896 0.4236560563966735 22.26774786416296 -10.873261476103796 14.469270236630152 1.0093976822526753 0.3590344198095262 0.9704088068121881 0.05276334532735978 0.014781226731323203 0.00012947063003660437 0.047209159460714537 0.017029296478587943 1.3388703497321151e-11 10.873261476103796 -0.6503632624431491 KYTLPPGVDPTQVSSSLSPEGTLTVEAPMPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYTLPPGVDPTQVSSSLSPEGTLTVEAPMPK 31 1 P04792 P04792 HSPB1 Heat shock protein beta-1 0 40577800.0 18979000.0 12622000.0 8976800.0 False True 15781879.412259003 12554002.780729145 10853807.375966357 1.0 0.7954694401591665 0.6877385824869101 23.911765685614395 -13.999999999530269 0.08043550109873202 2.0999882452823773 0.3686068149344653 0.9998848727693018 0.0013895515359058004 12.254240920203175 0.07992562150086553 2.3936204583732588 0.2896688409973883 1.0000000010815954e-14 13.999999999530269 -1.731381430347912 KYTLPPGVDPTQVSSSLSPEGTLTVEAPMPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYTLPPGVDPTQVSSSLSPEGTLTVEAPMPK 31 1 P04792 P04792 HSPB1 Heat shock protein beta-1 0 20968600.0 7941800.0 6669800.0 6357000.0 False True 10280816.656282185 6298619.766774598 5200091.228328221 1.0 0.6126575326995808 0.5058052684122772 23.293451533721207 -13.999999999999885 0.18070100189635274 3.014081894187073 0.421538417771126 0.9994973091598068 0.0047601509466487875 12.213926923965088 0.1347629065572396 8.638450825767348 0.07930722771430918 1.0000000000002658e-14 13.999999999999885 -2.5925434764159467 KYTLPPGVDPTQVSSSLSPEGTLTVEAPMPK(ub)LATQSNEITIPVTFESR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYTLPPGVDPTQVSSSLSPEGTLTVEAPMPKLATQSNEITIPVTFESR 48 2 P04792 P04792 HSPB1 Heat shock protein beta-1 1 161134000.0 23711000.0 37866000.0 99557000.0 True False 35971320.50629393 31108516.45159164 79879515.31261677 1.0 0.8648144136423505 2.220644507577646 25.10034378595654 -6.8823713081305815 1.066522817084293 0.9132782515816884 2.321195383124654 0.9755468702878156 0.09535487547910923 0.12554862839020045 0.2597887886490091 0.0687207530674356 0.1672269376643987 1.3110784888062798e-07 6.8823713081305815 1.4079171315429657 up KYTLPPGVDPTQVSSSLSPEGTLTVEAPMPK(ub)LATQSNEITIPVTFESR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYTLPPGVDPTQVSSSLSPEGTLTVEAPMPKLATQSNEITIPVTFESR 48 2 P04792 P04792 HSPB1 Heat shock protein beta-1 1 275523000.0 23711000.0 15162000.0 236650000.0 True False 30694356.91368544 14318221.371530842 193582128.23405257 1.0 0.46647732062915104 6.306766054047599 24.87147010804899 -6.884572587167341 1.053938070664447 0.6441652850189389 6.7587924726947985 0.9771916827660463 0.39816008268646186 0.12365808071407738 0.24844771863945864 0.2897049712588806 0.7094904008556187 1.3044499270980834e-07 6.884572587167341 6.114627187675859 up KYVATLGVEVHPLVFHTNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYVATLGVEVHPLVFHTNR 19 1 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 76231100.0 43856200.0 15658900.0 16716000.0 False True 42464008.936670214 21911580.43008472 12337578.130749209 1.0 0.5160035752338673 0.2905420010896562 25.339737243651545 -10.731700952315272 0.15499336666805638 1.9080173230415929 1.152719411055663e-10 0.9996460934418244 0.005568017131643144 2.691620852714769 0.08491755561385834 1.0975652628771382 0.1968508675796969 1.854808372823855e-11 10.731700952315272 -1.9080173229263209 KYVATLGVEVHPLVFHTNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYVATLGVEVHPLVFHTNR 19 1 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 1346045000.0 462673000.0 306098000.0 577274000.0 False True 701908766.9271017 251472420.3454098 463175540.8718178 1.0 0.35826938228216637 0.6598799768516382 29.38670828242724 -10.503512581468597 6.304037911727756 1.0003640323029657 0.5090746795670008 0.779368928984921 0.12313200961877623 0.0006304364422334191 4.9651166426158285e-05 0.11930711322131193 0.039740685219880965 3.136804255930066e-11 10.503512581468597 -0.49128935273596486 KYVATLGVEVHPLVFHTNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYVATLGVEVHPLVFHTNR 19 1 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 58295500.0 15590600.0 39583600.0 3121300.0 False True 21354866.14012304 37834665.66653928 2384113.2251913487 1.0 1.7717116753756101 0.1116426209158908 24.348061518895598 -6.780293306360197 1.5346758151321533 1.4367948749941857 0.09835899628228925 0.7684438742532573 0.32638917185206645 0.2501189144916998 1.1635729858345683 0.1675034348197006 0.3951495756146016 1.6584664624855367e-07 6.780293306360197 -1.3384358787118964 KYVATLGVEVHPLVFHTNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYVATLGVEVHPLVFHTNR 19 1 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 65667460.0 43856200.0 13887000.0 7924260.0 False True 36468373.45908184 13812187.974646328 9581186.128361462 1.0 0.3787442834582092 0.2627258969778765 25.12014251908582 -13.999999999999998 0.23596810812813868 5.033247681994991 0.20942724476235605 0.9995184997244669 0.00710282122741175 13.48453143590503 0.1537682546116235 25.567829312857096 0.05806587168384976 1.0000000000000041e-14 13.999999999999998 -4.823820437232635 KYVATLGVEVHPLVFHTNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYVATLGVEVHPLVFHTNR 19 1 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 1233385000.0 462673000.0 511863000.0 258849000.0 False True 598939319.1483095 483377374.08626103 211741138.01502773 1.0 0.8070556709711807 0.3535268619801472 29.15783460451969 -6.956768597614423 0.4788083128942108 1.0110089966854696 0.1307028019622519 0.9996309384556112 0.005205676289331702 0.08087630511260402 0.025554803113326457 0.006379247960143264 0.037413944013953954 1.104667055891611e-07 6.956768597614423 -0.8803061947232177 down KYVDKLEK(ub)IFQNAPTDPTQDFSTQVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYVDKLEKIFQNAPTDPTQDFSTQVAK 27 3 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 102791000.0 59366000.0 17898000.0 25527000.0 True False 57481458.825305484 25044764.736836992 18840712.90641512 1.0 0.4357016201163522 0.3277702635153152 25.776593340713234 -13.999999999999998 0.23258089187280723 4.605325125136675 0.27656536938375975 0.9995134251164861 0.00650204180085189 13.373047308427287 0.15268218225559385 22.297605598190145 0.055140385523466964 1.0000000000000041e-14 13.999999999999998 -4.328759755752915 KYVDKLEK(ub)IFQNAPTDPTQDFSTQVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYVDKLEKIFQNAPTDPTQDFSTQVAK 27 3 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 101116000.0 59366000.0 27769000.0 13981000.0 True False 49365459.35972226 27619402.885285094 16904362.459159806 1.0 0.5594884205173634 0.3424330023140073 25.55699861614751 -10.882872166256352 0.13655868737731447 1.9632155001313092 7.008041721594274e-15 0.9997379734288984 0.004428314919972165 3.0045272207892384 0.07818840183039079 1.1494429860442057 0.2286668628653295 1.3095673348948436e-11 10.882872166256352 -1.963215500131302 KYVDKLEK(ub)IFQNAPTDPTQDFSTQVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYVDKLEKIFQNAPTDPTQDFSTQVAK 27 3 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 408240000.0 147490000.0 159890000.0 100860000.0 True False 190928712.46254757 150991980.94539407 82504514.91099326 1.0 0.7908290953096567 0.432122093355536 27.508458835190606 -6.962937099294204 0.39184729193639556 1.021582076559697 0.188442165170692 0.9998641042128318 0.0027336520115317686 0.07866813548552107 0.017373013084376856 0.004626852723569468 0.030150401394055965 1.089087819104077e-07 6.962937099294204 -0.833139911389005 down KYVIYIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 KYVIYIER 8 1 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 50559000.0 16338000.0 14770000.0 19451000.0 False True 21419276.21741704 12566373.573009066 17438397.10716695 1.0 0.5866852570298685 0.8141450219959793 24.35240639475791 -10.104512709197058 5.211528003338872 1.0000064515307243 0.7004151395125466 0.6981556897258208 0.0928600601980442 6.960881670398001e-06 1.195991359732547e-06 0.08991330213239337 0.0299704555560473 7.861171858721442e-11 10.104512709197058 -0.2995913120181777 KYVIYIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 KYVIYIER 8 1 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 34464500.0 12385000.0 4411500.0 17668000.0 False True 11991844.954206264 6173034.955668587 13040220.77136142 1.0 0.5147694103152436 1.087424063699842 23.51555029973772 -6.682160969688301 1.894091977821174 0.6935838999524404 1.085286997510889 0.33403831948261753 0.20555637180351327 0.43377298379256823 3.010555418689665 0.08701985601369865 0.2288854648595651 2.0789259978391684e-07 6.682160969688301 0.39170309755844857 KYVIYIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYVIYIER 8 1 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 37213000.0 10142000.0 12143000.0 14928000.0 False True 15386155.479517225 9975986.77630797 11977474.256825157 1.0 0.6483742341996006 0.7784578982560091 23.87512945640252 -10.119891695826688 5.563661492164934 1.0000036360272926 0.7134160668769727 0.8661559139516577 0.053106433468492094 2.395239944237282e-06 3.7887312791528455e-07 0.05142073581045559 0.017140027699967888 7.587667723724282e-11 10.119891695826688 -0.2865875691503199 KYVIYIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYVIYIER 8 1 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 32634400.0 16338000.0 7141100.0 9155300.0 False True 22378600.117848553 6825582.589540215 6993006.699322185 1.0 0.30500489546244314 0.3124863334836014 24.4156164562808 -10.487609356853756 9.496514019451158 1.0000094126730485 0.30874561447416216 0.9999121545992514 0.0030542842823492013 6.086876634702868e-07 3.284531012128778e-08 0.0029573381919812654 0.0009857660133434584 3.253798414115315e-11 10.487609356853756 -0.6912637981988864 KYVIYIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 KYVIYIER 8 1 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 26193500.0 12385000.0 8105900.0 5702600.0 False True 10298676.2485288 8062231.907804821 6894987.294156691 1.0 0.782841572377473 0.669502286290596 23.295955575171995 -13.999999999998987 0.08216323530830179 2.1562308553694325 0.34418577771359715 0.9998775915871501 0.001517130300797425 12.237238200325043 0.081273114317977 2.546987047055412 0.2946714455198215 1.0000000000023314e-14 13.999999999998987 -1.8120450776558354 KYVIYIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYVIYIER 8 1 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 57506000.0 10142000.0 29469000.0 17895000.0 False True 13129018.928708097 27829024.24466709 14638293.618205687 1.0 2.119657561298488 1.1149571569431886 23.646255778494968 -6.620204360509041 2.115826403014302 1.74282172608488 1.11879064945084 0.08345750488906056 0.48146757109167054 0.5849305357165512 4.976072035754219 0.18695117080771279 0.5338958942682391 2.3977043958283695e-07 6.620204360509041 -0.62403107663404 KYVVGLIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 KYVVGLIIK 9 1 O14980;C9JKM9;C9J673 O14980 XPO1 Exportin-1 0 19394000.0 5044500.0 8438800.0 5910700.0 False True 7652875.302349102 6932830.207354661 4742447.554248155 1.0 0.9059118218255278 0.6196948685146391 22.86757046158362 -6.951137490979824 0.5462117843734156 1.0040501174637484 0.508197554944121 0.9992875596431872 0.004316782814748276 0.08303214924774645 0.03409655051957266 0.004708476733288027 0.023727652077562743 1.1190835426747957e-07 6.951137490979824 -0.4958525625196274 KYVVGLIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 KYVVGLIIK 9 1 O14980;C9JKM9;C9J673 O14980 XPO1 Exportin-1 0 5375200.0 1137800.0 1851900.0 2385500.0 False True 1558475.407888853 1770076.9345856402 1822094.0309146724 1.0 1.1357746972622607 1.1691516091247942 20.571703959323248 -13.999999999999098 0.1970673938330685 0.2535095373828606 1.1914653677918223 0.9994870413536451 0.0016567816519622517 12.47430211196389 0.1407693937234258 3.5850026098446723 0.021726768784652458 1.0000000000020779e-14 13.999999999999098 0.9379558304089617 KYVVGLIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 KYVVGLIIK 9 1 O14980;C9JKM9;C9J673 O14980 XPO1 Exportin-1 0 14010600.0 5044500.0 4638800.0 4327300.0 False True 6530204.691960949 4380646.70216708 3539775.8018475254 1.0 0.6708283903504438 0.5420619978735413 22.63869678367607 -13.99999999999882 0.1297593763672266 2.5642533805042995 0.3611812457209154 0.9996467065840566 0.0036244002784342273 11.937114876555071 0.11199660568750718 4.763412913419242 0.1608486985277365 1.0000000000027159e-14 13.99999999999882 -2.203072134783384 LAAAFAVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAAAFAVSR 9 0 P55084-2;P55084;F5GZQ3 P55084-2 HADHB Trifunctional enzyme subunit beta, mitochondrial;3-ketoacyl-CoA thiolase 0 16563100.0 4758200.0 4819700.0 6985200.0 False True 6238046.278474346 4100619.547043456 6262438.510769761 1.0 0.6573563843528193 1.0039102358665701 22.572662825062494 -10.975338212320462 10.635351436378901 1.0925851257397294 0.8306333101096945 0.24153869039421583 0.1414800174341562 0.07876988492630776 0.0001826554684144537 0.034741710724932595 0.04566247927863517 1.0584291390621471e-11 10.975338212320462 -0.2619518156300349 LAAAFAVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAAAFAVSR 9 0 P55084-2;P55084;F5GZQ3 P55084-2 HADHB Trifunctional enzyme subunit beta, mitochondrial;3-ketoacyl-CoA thiolase 0 8676800.0 4188700.0 1486900.0 3001200.0 False True 4055732.011278455 2080626.9240810634 2215095.685929923 1.0 0.5130089755178879 0.5461642139495495 21.951530896524215 -10.42845345341892 6.732907354404393 1.0000667277469972 0.5295865947337263 0.9962881430005188 0.01353556940964761 1.3559759375675395e-05 1.151073057937214e-06 0.01310760362953674 0.004368586242083308 3.7286064505976704e-11 10.42845345341892 -0.47048013301327096 LAAAFAVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAAAFAVSR 9 0 P55084-2;P55084;F5GZQ3 P55084-2 HADHB Trifunctional enzyme subunit beta, mitochondrial;3-ketoacyl-CoA thiolase 0 33772100.0 7824100.0 11698000.0 14250000.0 False True 11869731.718328798 9610400.503108824 11433481.254003134 1.0 0.8096560841614306 0.9632468134345427 23.500783991524074 -9.982376988535744 5.362743625766183 1.000000396214409 0.8864514488258265 0.4215436296700391 0.06270315265793024 2.9703449848779115e-07 5.634528618956511e-08 0.060712278193622314 0.020237355499748713 1.0414130402264661e-10 9.982376988535744 -0.11354894738858257 LAAAFAVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAAAFAVSR 9 0 P55084-2;P55084;F5GZQ3 P55084-2 HADHB Trifunctional enzyme subunit beta, mitochondrial;3-ketoacyl-CoA thiolase 0 16545100.0 4758200.0 5946600.0 5840300.0 False True 6517435.125520081 5683859.549223487 4460941.42475412 1.0 0.8721006714692728 0.6844627278738189 22.635872886585386 -6.965623465660735 0.34718609979460857 1.018730208076565 0.5315288649199669 0.9999254241886971 0.001119044376448436 0.07775002777957872 0.014117534160348487 0.0025946462797737453 0.01615855408550919 1.0823719636529155e-07 6.965623465660735 -0.48720134315659813 LAAAFAVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAAAFAVSR 9 0 P55084-2;P55084;F5GZQ3 P55084-2 HADHB Trifunctional enzyme subunit beta, mitochondrial;3-ketoacyl-CoA thiolase 0 6679900.0 4188700.0 2491200.0 0.0 False True 3483089.640873031 2477779.411135515 0.0 1.0 0.711374000272489 0.0 21.73193617195849 -7.406234232090944 0.7580142574754191 0.9905255629852043 6.7876391421381106e-18 0.987427077078762 0.047120265193481774 0.1136060691663915 0.1391681331886004 0.04084771220561451 0.07323393909671408 3.924332236441523e-08 7.406234232090944 -0.9905255629852043 down LAAAFAVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAAAFAVSR 9 0 P55084-2;P55084;F5GZQ3 P55084-2 HADHB Trifunctional enzyme subunit beta, mitochondrial;3-ketoacyl-CoA thiolase 0 44701100.0 7824100.0 21352000.0 15525000.0 False True 10128451.686068326 20163742.43008351 12699609.29995213 1.0 1.9908020549496932 1.2538549517317072 23.271910313616523 -10.20673622209249 4.522212153226081 0.9998500865828658 1.6223285033459942 0.4873991750275055 0.3008573951452304 0.0004883480003509785 8.56631419036065e-05 0.2913784224405733 0.09710130673448282 6.212462466668571e-11 10.20673622209249 0.6224784167631284 LAAAILGGVDQIHIK(ub)PGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAAAILGGVDQIHIKPGAK 19 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 7817500.0 2813100.0 2397600.0 2606800.0 True False 2339217.291460344 2384683.6529136635 3151869.827518614 1.0 1.0194365703516732 1.34740361189402 21.15759445014743 -6.919053375593132 0.8317223683612358 0.992513789998901 1.3991557596527633 0.9939138098616788 0.012434190698805539 0.09873189282618351 0.10852564254007147 0.010659973855375647 0.03164813450485574 1.2048878483319235e-07 6.919053375593132 0.40664196965386223 LAAAILGGVDQIHIKPGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAAAILGGVDQIHIKPGAK 19 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 91713000.0 40503000.0 27701000.0 23509000.0 False True 53099825.23160998 23568118.77765229 21076514.194251593 1.0 0.4438455056086012 0.3969224776601502 25.66220377688118 -13.999999999999998 0.3502312008503354 7.849210317727007 0.3904594997816797 0.99975514943232 0.004285968886279823 20.682949441333914 0.19052367028104022 105.40349983226281 0.013989084023315937 1.0000000000000041e-14 13.999999999999998 -7.458750817945327 LAAAILGGVDQIHIKPGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAAAILGGVDQIHIKPGAK 19 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 44044100.0 17751000.0 7478100.0 18815000.0 False True 17187504.22140616 10464144.327776318 13886787.062099 1.0 0.6088227931745762 0.8079583215347644 24.034856732075163 -10.28074775883458 4.752927504432142 1.0001112366300127 0.7083905573541696 0.7408788782849787 0.08129673902538548 9.586254046938742e-05 1.4506660641874005e-05 0.07874513655236956 0.02623840969527996 5.2390463558409006e-11 10.28074775883458 -0.2917206792758431 LAAAILGGVDQIHIKPGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAAAILGGVDQIHIKPGAK 19 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 63635500.0 5383500.0 44260000.0 13992000.0 False True 8167163.086568814 36361457.19504159 11226475.067088544 1.0 4.452152700959196 1.374586860589435 22.961403605873116 -6.618562445390707 2.1218258981466125 3.2928752792041247 1.3861821913230008 0.07802758556331468 1.4850822109603123 0.5892890738647077 5.039281371068303 0.5754730444270371 1.64711985101612 2.406786432394956e-07 6.618562445390707 -1.906693087881124 LAAAILGGVDQIHIKPGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAAAILGGVDQIHIKPGAK 19 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 78518000.0 40503000.0 16199000.0 21816000.0 False True 55478053.652418986 15483274.617070455 16663510.114623552 1.0 0.27908828081958753 0.30036219761824645 25.725413838404073 -10.14080174755638 4.915049528379957 1.0000424874496123 0.28972523921642557 0.9993276250933464 0.008685040173242144 24279844.642447215 0.4410550158125907 11679.246047737965 0.0029731202585072357 7.23099818364824e-11 10.14080174755638 -0.7103172482331868 LAAAILGGVDQIHIKPGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAAAILGGVDQIHIKPGAK 19 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 31504500.0 17751000.0 6059500.0 7694000.0 False True 14760743.002635017 6026856.270783416 9302779.826963415 1.0 0.4083030420424995 0.6302379104698678 23.81526200750944 -10.183300269735053 5.381694764193844 1.0000193496062832 0.5192704762560918 0.8621809701496047 0.09060453063014459 2.10358673337019e-05 3.1922724523083487e-06 0.08773098533479333 0.029242486518407003 6.556917664784911e-11 10.183300269735053 -0.48074887335019145 LAAAILGGVDQIHIKPGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAAAILGGVDQIHIKPGAK 19 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 43213500.0 5383500.0 22937000.0 14893000.0 False True 6969046.874649968 21660535.786756568 12182626.815084489 1.0 3.1081059112325895 1.748105161897965 22.732529927965565 -10.418339261466688 6.093870130410433 0.999592436734339 2.4281055365652757 0.595177047662002 0.5552179809454342 0.0030751289492477662 0.00029352258682220666 0.5377231788291724 0.17919583280971432 3.8164602073569406e-11 10.418339261466688 1.4285130998309368 LAACVNLIPQITSIYEWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAACVNLIPQITSIYEWK 18 0 C9IZG4;O60888-3;O60888;O60888-2;C9IZQ5 C9IZG4 CUTA Protein CutA 0 317468000.0 95938000.0 120840000.0 100690000.0 False True 145544960.00728875 99275157.87277068 80788577.36600518 1.0 0.6820927215054309 0.5550764338521881 27.116889641167727 -13.999999999999956 0.12653945425157417 2.510824778609402 0.36912652320414446 0.9996615515072466 0.0034426005547234743 11.943443130113858 0.110264826394887 4.5029903155558575 0.1651883645876773 1.0000000000001022e-14 13.999999999999956 -2.1416982554052573 LAACVNLIPQITSIYEWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAACVNLIPQITSIYEWK 18 0 C9IZG4;O60888-3;O60888;O60888-2;C9IZQ5 C9IZG4 CUTA Protein CutA 0 212589000.0 95938000.0 49123000.0 67528000.0 False True 124193632.22070564 46389261.86741254 55238596.8957918 1.0 0.37352367458722646 0.44477801243164206 26.888015963260177 -10.399789283443978 5.930931657499022 1.0001628050529534 0.4091508435117855 0.9892100562478617 0.029089461613118612 6.263911532396181e-05 6.339121590155446e-06 0.028173370270502554 0.00938858336481215 3.983003761537672e-11 10.399789283443978 -0.591011961541168 LAADVGK(ub)AGAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAADVGKAGAER 12 1 P05141 P05141 SLC25A5 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed 1 8534500.0 2352700.0 2152600.0 4029200.0 True False 3084412.4835792105 1831440.4707690794 3612297.0348155373 1.0 0.5937728758780801 1.1711459002473494 21.556564281471204 -6.71764876453503 1.767919721455576 0.7522324635651906 1.1701192362976531 0.50130065503313 0.17099356203213614 0.3599227438107371 2.197258135558339 0.07683797842389194 0.1934170517116131 1.9158047048340042e-07 6.71764876453503 0.41788677273246255 LAADVGK(ub)AGAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAADVGKAGAER 12 1 P05141 P05141 SLC25A5 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed 1 10382300.0 2719700.0 3418100.0 4244500.0 True False 2633364.612188511 4782965.155156025 3132738.117729424 1.0 1.8162943076769928 1.1896332559606695 21.328475858189435 -10.435205056457312 5.436841244730949 0.9995725982782848 1.5029637818188346 0.46204982422172847 0.25583330306348734 0.0013264723456784895 0.0001377970092577387 0.2479128601230278 0.08256984351417508 3.6710892544204626e-11 10.435205056457312 0.5033911835405498 LAADVGK(ub)AGAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAADVGKAGAER 12 1 P05141 P05141 SLC25A5 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed 1 36458200.0 8287600.0 11345000.0 16825600.0 True False 12572895.104717707 9320396.11111041 13500012.785077548 1.0 0.7413086670557788 1.07373939515426 23.58381355520313 -6.699054509131614 1.8345121925307972 0.8392101942758117 1.0727237152020879 0.4129457841516311 0.10921637775589438 0.3975044160245228 2.6002298616267936 0.04751003589458129 0.122313807519711 1.9996108788934732e-07 6.699054509131614 0.2335135209262762 LAADVGK(ub)AGAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAADVGKAGAER 12 1 P05141 P05141 SLC25A5 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed 1 9083900.0 2352700.0 2086000.0 4645200.0 True False 3222556.7693268675 1993833.6225204638 3548099.430897018 1.0 0.6187117140955561 1.101019992779879 21.619774342994095 -6.695965706495906 1.8450608578473457 0.7623090675495939 1.0994911627045338 0.39855361661586586 0.16106787358004382 0.40397000853728887 2.6706463634253295 0.06971652720112377 0.18020386393994003 2.0138832672809374e-07 6.695965706495906 0.3371820951549399 LAADVGK(ub)AGAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAADVGKAGAER 12 1 P05141 P05141 SLC25A5 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed 1 12287100.0 2719700.0 5212500.0 4354900.0 True False 2261551.0531387744 5184419.227899757 5265489.455217441 1.0 2.292417507314007 2.3282646871533337 21.10888113362371 -10.80984053188914 0.6392518494989741 3.3370492668326014e-16 2.323128293270616 0.9999262395037963 0.00530654212212478 2.481858384916473 0.31842051936156623 3.796280780922863 0.005941943372996725 1.549385431599602e-11 10.80984053188914 2.3231282932706154 LAADVGK(ub)AGAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAADVGKAGAER 12 1 P05141 P05141 SLC25A5 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed 1 29985330.0 8287600.0 6517930.0 15179800.0 True False 10728461.573019251 6155201.465779056 12417232.157901017 1.0 0.5737263841498601 1.1574103214508233 23.35493987729558 -6.710927789090608 1.7920034332044679 0.7381798896033746 1.1560691923031037 0.4694214764936673 0.1796041477606346 0.37323368722980027 2.33697511896656 0.07974297717485045 0.20234902520983658 1.9456835669666056e-07 6.710927789090608 0.4178893026997291 LAAFGQLHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAAFGQLHK 9 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 29286100.0 12374000.0 8608800.0 8303300.0 False True 16222433.829986459 7324400.596839576 7444154.166877766 1.0 0.45149825689538287 0.458880229988522 23.951486945606597 -10.34686833688387 8.881565076149526 1.000000861815506 0.455189243442389 0.9998623245102181 0.0030136778955242925 5.1428691251206236e-08 3.781925191320405e-09 0.002917985661419907 0.0009726603583499163 4.4991623331227685e-11 10.34686833688387 -0.5448116183731171 LAAFGQLHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAAFGQLHK 9 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 13971500.0 4058900.0 1604000.0 8308600.0 False True 3930052.441229533 2244485.5647494975 6132328.4073428465 1.0 0.5711082990147839 1.560368086443224 21.906117132748772 -6.788875132480405 1.5007716159846944 0.7599366309577905 1.5705724258507041 0.7976582460599771 0.18220162975892087 0.23704218200067123 1.0547374870066935 0.0955649281643696 0.2239306840258627 1.626016197618444e-07 6.788875132480405 0.8106357948929136 LAAFGQLHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAAFGQLHK 9 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 21402600.0 12374000.0 4450400.0 4578200.0 False True 16949002.19477649 4253766.612495241 3496923.450988706 1.0 0.2509744564081895 0.20632031377436616 24.014697007129488 -13.602028691213972 0.4048078024901916 9.999753918411043 0.20394227718697497 0.9998371644945454 0.004645859075004394 19.661116044161172 0.20976306985113455 153.7743261887702 0.01128015814149549 2.5001801844326818e-14 13.602028691213972 -9.795811641224068 LAAFGQLHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAAFGQLHK 9 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 10239100.0 4058900.0 4098700.0 2081500.0 False True 3375155.189758055 4076619.4895717506 2516732.0262313937 1.0 1.2078317174695543 0.7456640909041589 21.68652240818305 -6.784423778859111 1.5182768824532 1.117003094249306 0.7414581639915119 0.7828447169634543 0.08807257952499062 0.2437606168111624 1.1100303754351506 0.04567289440702914 0.10739363591324082 1.642767949453422e-07 6.784423778859111 -0.37554493025779423 LAAFGQLHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAAFGQLHK 9 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 18665200.0 5223300.0 7094100.0 6347800.0 False True 6761664.816635866 6699307.098784909 5192565.533928244 1.0 0.9907777567297424 0.7679418715273887 22.68894707130487 -6.915602577995136 0.8566985236717581 1.0057381111500072 0.7354057414349083 0.9928698259726135 0.009059235108556348 0.10082886050317742 0.1195300832875951 0.007628855999955506 0.021974020692005387 1.214499728359419e-07 6.915602577995136 -0.2703323697150989 LAAIAESGVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAAIAESGVER 11 0 P28072 P28072 PSMB6 Proteasome subunit beta type-6 0 12609400.0 2118900.0 5172900.0 5317600.0 False True 2777898.4194567897 4401123.48380627 4767385.762021029 1.0 1.584335644881823 1.7161843387179285 21.405562413990715 -11.433681542881086 0.26352282289417966 4.1684335936396765e-14 1.7697576165230084 0.9993041844935454 0.008209604269150485 3.7995262185249503 0.14465208481814948 2.2348111840344367 0.05637053626453029 3.683990122679994e-12 11.433681542881086 1.7697576165229667 LAAIAESGVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAAIAESGVER 11 0 P28072 P28072 PSMB6 Proteasome subunit beta type-6 0 11083200.0 2118900.0 4331100.0 4633200.0 False True 2902314.5911194375 4139737.6809675866 3538933.5837492575 1.0 1.426357326540149 1.219348720699596 21.468772475513607 -10.129907469007874 4.36815206738551 0.999950648585256 1.3228530236067066 0.764327944666104 0.08451090951714964 59467510.028898224 33922749.79999575 32955.73247973708 0.030927825557377196 7.414682020460624e-11 10.129907469007874 0.3229023750214507 LAALNPESNTAGLDIFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAALNPESNTAGLDIFAK 18 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 62431000.0 11081000.0 28392000.0 22958000.0 False True 14527298.308556652 24156024.271149166 20582526.38868638 1.0 1.6628022470579507 1.416817218970658 23.792263089187745 -10.377593855991938 5.463324389308808 0.9997852990114131 1.5398097330143108 0.8652473082691006 0.1004229671963651 0.00026272144277862805 2.993008488973477e-05 0.09727207400560431 0.03241137329401804 4.1918539614891034e-11 10.377593855991938 0.5400244340028977 LAALNPESNTAGLDIFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAALNPESNTAGLDIFAK 18 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 113226000.0 49981000.0 19998000.0 43247000.0 False True 48394380.513216175 27983305.688192338 31919313.317809943 1.0 0.5782346088829526 0.659566523619266 25.528336197736287 -10.060307685499732 5.125194382587176 1.000005820125701 0.6189005662498869 0.9669691844224125 0.03320361515554296 2.2082059855815905e-06 4.0488563179473163e-07 0.03214975301713276 0.010716420710325329 8.703467551312889e-11 10.060307685499732 -0.38110525387581407 LAALNPESNTAGLDIFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAALNPESNTAGLDIFAK 18 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 180864000.0 7722600.0 164260000.0 8881400.0 False True 11715748.797684846 134946519.63076225 7125987.3971441 1.0 11.518386230458363 0.6082400297411864 23.48194582943975 -6.654505146224473 1.9926803939991733 7.800964388300212 0.6542394884146069 0.21246864946464517 4.484434954406025 0.4975578627808273 3.7920055076330828 1.822040003279667 4.967865668752411 2.215617841928356e-07 6.654505146224473 -7.146724899885605 LAALNPESNTAGLDIFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAALNPESNTAGLDIFAK 18 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 93137000.0 11081000.0 49275000.0 32781000.0 False True 15177945.152765343 47097867.56936524 25038802.945887186 1.0 3.103046367299875 1.6496833197032106 23.855473150710637 -10.495412902715625 6.238694873323493 0.9990210443574308 2.376364843501416 0.5445846039676854 0.5933329796046884 0.008083231661495058 0.0006537733916594144 0.5747864076071142 0.19149739573038202 3.1958552258218015e-11 10.495412902715625 1.3773437991439852 LAALNPESNTAGLDIFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAALNPESNTAGLDIFAK 18 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 67611800.0 49981000.0 8713200.0 8917600.0 False True 41561416.03372767 8666260.262165217 10782228.929676227 1.0 0.20851696330876757 0.2594288154408959 25.308741473170564 -9.87529093269761 6.568138594947075 1.0000000314050221 0.233972889374795 0.9966980202501786 0.020784676597441036 9.550361468312908e-09 1.6436496547858765e-09 0.020124677479120813 0.0067082255264941035 1.332628408916644e-10 9.87529093269761 -0.7660271420302271 LAALNPESNTAGLDIFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAALNPESNTAGLDIFAK 18 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 35884600.0 7722600.0 16075000.0 12087000.0 False True 9997057.935204213 15180412.11893932 9887290.023093149 1.0 1.5184879608911883 0.9890199783953916 23.253072151532198 -10.861597602166203 3.8200643286395057 0.9248891558655002 1.253753969640413 0.23445344835867965 0.21615439871106687 0.12506148989917176 0.004531023801922845 0.18929154974491053 0.0697635322012054 1.3753156908159777e-11 10.861597602166203 0.3288648137749127 LAALPNVYEVISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAALPNVYEVISK 13 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 17392900.0 3087900.0 7883800.0 6421200.0 False True 4048266.8032661346 6707567.7708117105 5756795.820499743 1.0 1.6568986425005527 1.4220396283800194 21.948872944105563 -10.267890277344952 5.178224088227484 0.9999127152441551 1.5394691354404 0.8755428296652628 0.0958807910151335 9.663222897825799e-05 1.3661956277500137e-05 0.09285109452311703 0.030945392235176634 5.396469448008178e-11 10.267890277344952 0.5395564201962448 LAALPNVYEVISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAALPNVYEVISK 13 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 9900100.0 3736600.0 1990100.0 4173400.0 False True 3617983.678311433 2784757.308234399 3080261.340683705 1.0 0.7696986929288987 0.8513751344841083 21.7867544689162 -10.776133111460332 9.8195796015866 1.00120017857928 0.8105369149851736 0.877669021987372 0.03334426763608595 0.0008810196054334644 2.0085471990401605e-05 0.03246611573489972 0.01076181610383699 1.6744295839234656e-11 10.776133111460332 -0.19066326359410635 LAALPNVYEVISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAALPNVYEVISK 13 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 17797800.0 3087900.0 6862600.0 7847300.0 False True 4229580.0773598105 6559387.640416548 5993929.360216599 1.0 1.5508366127237507 1.41714526042456 22.012083005628455 -10.041506807796598 4.706993647818865 0.9999858519950405 1.4839909365306823 0.9458715481569788 0.05457926607625322 8.534890546454149e-06 1.7381622711180575e-06 0.052847773434669926 0.01761538239264237 9.088520522154404e-11 10.041506807796598 0.4840050845356417 LAALPNVYEVISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAALPNVYEVISK 13 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 6499500.0 3736600.0 1025200.0 1737700.0 False True 3107148.4594471287 1019677.0441137336 2101045.0357829877 1.0 0.3281713305373153 0.6761971831100847 21.567159744350477 -10.63877291760448 6.719374183416183 1.0018614385123754 0.502184256824056 0.7317635487520124 0.14208095935006154 0.003973519923363182 0.0002136121301943906 0.13796903649049366 0.045856432447996774 2.2973495643081577e-11 10.63877291760448 -0.4996771816883194 LAALPVAGALIGGMVGGPIGLLAGFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAALPVAGALIGGMVGGPIGLLAGFK 26 0 P56962 P56962 STX17 Syntaxin-17 0 350267000.0 152690000.0 118450000.0 79127000.0 False True 231641893.13424224 97311672.04592602 63487513.76740385 1.0 0.42009530629043634 0.2740761306531511 27.787320951767153 -13.999999999999797 0.19366544604658528 4.149019342311205 0.17309803278906993 0.9994878077282808 0.007095170158288298 12.4127343797653 0.13955701530324593 14.76943438627132 0.09756849149238278 1.0000000000004662e-14 13.999999999999797 -3.975921309522135 LAASIAPEIYGHEDVK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAASIAPEIYGHEDVKK 17 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 23752800.0 3569200.0 9820600.0 10363000.0 True False 2967947.9423697186 9767694.478563529 12529855.386901734 1.0 3.2910599067868564 4.221723436596882 21.50103435671965 -9.213415043125162 0.30673395976948925 7.558611001387056e-20 4.5948594918444705 0.9985924267965816 0.05079079685527502 0.6266140350439593 0.11426600459068448 1.0108412614446458 0.3135643477422112 6.117654650756118e-10 9.213415043125162 4.5948594918444705 LAASIAPEIYGHEDVKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAASIAPEIYGHEDVKK 17 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 11168400.0 3405300.0 4709400.0 3053700.0 False True 4464381.276972108 4006775.8770974227 2737732.417158797 1.0 0.8974985845776488 0.6132389344253362 22.090028813988408 -6.9532031199614845 0.5224970526797319 1.0047387810428288 0.4932589724207668 0.9994292689728017 0.003908473707463916 0.08222447034340186 0.030832374606821762 0.004410406366975824 0.023485995217503358 1.1137734987829433e-07 6.9532031199614845 -0.511479808622062 LAASIAPEIYGHEDVKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAASIAPEIYGHEDVKK 17 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 14344200.0 3405300.0 7275500.0 3663400.0 False True 4664331.434772293 6954044.353138854 2798180.370091305 1.0 1.4908984171443944 0.5999102785087375 22.1532388755113 -6.757142400846076 1.6234239131885562 1.2861507100862555 0.597125114785502 0.6791464161551368 0.20639554462013598 0.2877285729676714 1.493909257932975 0.10034827562608022 0.24181915989576977 1.7492730253338617e-07 6.757142400846076 -0.6890255953007535 LAASIAPEIYGHEDVKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAASIAPEIYGHEDVKK 17 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 11534000.0 1852400.0 6143700.0 3537900.0 True False 2428514.3386671157 5227083.907955029 3171832.045933163 1.0 2.1523792652687823 1.3060791922991137 21.21164257380929 -10.257595582482363 5.005647985682917 0.9998598319955208 1.7292292287843776 0.4974776056674388 0.34550055801079954 0.0005405576242063936 8.017067886893656e-05 0.33459288232706363 0.11150982560655315 5.525917764049327e-11 10.257595582482363 0.7293693967888568 LAASIAPEIYGHEDVKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAASIAPEIYGHEDVKK 17 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 23493200.0 2162900.0 10468300.0 10862000.0 True False 2094239.9234116026 14648346.781463308 8016916.346984809 1.0 6.994588641783006 3.8280792269134687 20.997995301224254 -9.36162814877959 9.725307144902736 1.0000014024796575 5.411333934348265 0.7212713354080198 1.292722055358572 0.0 0.0 1.2516727852222358 0.41722424930651064 4.348824194322311e-10 9.36162814877959 4.411332531868608 LAASIAPEIYGHEDVKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAASIAPEIYGHEDVKK 17 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 171762500.0 12136900.0 9565600.0 150060000.0 True False 15711456.30406599 9033265.951161804 122750619.74562414 1.0 0.5749477181707257 7.812809797514272 23.905313575287913 -6.892962386812664 1.0047221868871388 0.6382664985344053 8.472631440259384 0.9827266885849985 0.4358569629063151 0.11677139707858177 0.20808456432034042 0.329195381709236 0.8299203769702361 1.279492113054667e-07 6.892962386812664 7.834364941724979 up LAASLWLWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAASLWLWK 9 0 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 0 77416000.0 29903000.0 31489000.0 16024000.0 False True 45365037.202130154 25869541.92532007 12856849.376431314 1.0 0.5702528537572839 0.2834087696025875 25.435077506058185 -8.27766383452201 0.2257867418173378 1.2421620250987833 3.0598216356133795e-10 0.9996324808498863 0.005645406995543973 0.093626518751979 0.05046412215323968 0.10730481102229532 0.11094174484423884 5.276381214822539e-09 8.27766383452201 -1.2421620247928011 down LAASLWLWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAASLWLWK 9 0 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 0 6143100.0 3630700.0 1407800.0 1104600.0 False True 3019087.9172816686 1400215.9019735784 1335566.7529066545 1.0 0.46378772011194264 0.44237424993876107 21.52568133875586 LAASLWLWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAASLWLWK 9 0 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 0 78127000.0 29903000.0 32181000.0 16043000.0 False True 38710022.97625306 30390099.060627516 13123338.615080958 1.0 0.7850705508304797 0.33901655452727486 25.206203828150635 -6.9593150814619795 0.44498195776696026 1.0151453921797176 0.09140608200851426 0.9997439454771141 0.004405094566799615 0.07994670883044315 0.02204226801650568 0.005919351970947672 0.036925400682195735 1.0982087977952656e-07 6.9593150814619795 -0.9237393101712033 down LAATNALLNSLEFTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAATNALLNSLEFTK 15 0 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 0 11608900.0 1075700.0 7134700.0 3398500.0 False True 1410253.11709362 6070230.57084277 3046855.820713943 1.0 4.3043553651934925 2.160502808880994 20.427522695070735 -9.212850287678151 10.054314271509282 0.9999999999998235 3.232429087004129 0.5911336176619073 0.8752241411217427 0.0 0.0 0.8474321306905375 0.28247737689684577 6.12561520823016e-10 9.212850287678151 2.2324290870043058 LAATNALLNSLEFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAATNALLNSLEFTK 15 0 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 0 19166000.0 1075700.0 8472400.0 9617900.0 False True 1473415.359699458 8098061.3535198355 7346350.106868245 1.0 5.496115742387571 4.98593289292622 20.490732756593626 -10.16135502429106 4.580733643159659 0.9993893573566667 5.241024317707206 0.9892629935817487 0.20828127633429128 36465624.07974316 277.057920768499 234906.4816437601 0.07130022081387762 6.896757815632356e-11 10.16135502429106 4.241634960350539 LAAVALINAAIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAAVALINAAIQK 13 0 P46940;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 5525400.0 1436400.0 2327300.0 1761700.0 False True 1883134.3101173888 1980075.9117443487 1579416.1834196725 1.0 1.0514788568750133 0.8387166942549183 20.844704469770257 -6.842788107312177 1.2693965090693362 1.0273828617635357 0.8313239193082922 0.9291452464356678 0.024125366592462512 0.16556286218825494 0.5170202903603689 0.014895550780597223 0.03434621661395851 1.436189980888722e-07 6.842788107312177 -0.19605894245524347 LAAVALINAAIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAAVALINAAIQK 13 0 P46940;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 10676000.0 4070500.0 2867400.0 3738100.0 False True 3941284.2055790536 4012367.7732934644 2758979.4694037815 1.0 1.0180356361040366 0.7000204312843844 21.910234355134815 -6.8934621977692245 1.0016522252999631 1.0156962359529145 0.670735656787342 0.9830241660659136 0.019002827359606827 0.11637991830893402 0.2057869604872873 0.014385247892531525 0.03634067890452911 1.2780204472710004e-07 6.8934621977692245 -0.34496057916557243 LAAVALINAAIQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAAVALINAAIQK 13 0 P46940;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 19658300.0 4523400.0 10207000.0 4927900.0 False True 6862328.5048361495 8385481.102345005 3953898.4050246994 1.0 1.2219585664596835 0.576174457727903 22.71026675977149 -6.813912703195635 1.3979917797656312 1.1204174589461031 0.5638328178340545 0.8698122887590231 0.09666221460482521 0.20150819739694673 0.7754093099795344 0.05435623724089294 0.12553114353395037 1.5349254845861327e-07 6.813912703195635 -0.5565846411120486 LAAVALINAAIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAAVALINAAIQK 13 0 P46940;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 6559200.0 1436400.0 1533300.0 3589500.0 False True 1967475.8972504423 1465553.73605495 2741734.0280730277 1.0 0.7448903125588826 1.393528648510823 20.907914531293148 -6.799998807025671 1.4557956993677954 0.8592464929799642 1.4024963050472832 0.8322084462903564 0.10929077573696724 0.22074901001860683 0.92361794122445 0.059058298584215504 0.13735539809623673 1.584897546049678e-07 6.799998807025671 0.5432498120673189 LAAVALINAAIQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAAVALINAAIQK 13 0 P46940;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 7368900.0 4070500.0 1518600.0 1779800.0 False True 3384801.103725189 1510419.0003814998 2151947.951134583 1.0 0.4462356735582447 0.6357679181699117 21.69063963056909 -10.18049401887659 4.858526815158539 1.0000478870999578 0.5410017958626973 0.886618477828673 0.07737621485526477 4.014011096172387e-05 6.770558338397902e-06 0.07492699204799552 0.024973065959904204 6.599423229567458e-11 10.18049401887659 -0.4590460912372606 LAAVALINAAIQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAAVALINAAIQK 13 0 P46940;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 13296800.0 4523400.0 6766400.0 2007000.0 False True 5855630.4695442915 6389843.89185637 1641746.5935590274 1.0 1.0912307265785597 0.2803705940970682 22.48139308186394 -6.878945475706815 1.0856307297873313 1.0557961625083434 0.2240475012878844 0.972826281939099 0.05978209166036263 0.1285698197609432 0.27794720065706113 0.04245759997846418 0.10240667142657668 1.3214615290714989e-07 6.878945475706815 -0.831748661220459 down LAAVDATVNQVLASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAAVDATVNQVLASR 15 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 72644000.0 20657000.0 30276000.0 21711000.0 False True 27081527.04267258 25758938.81492366 19464553.98661772 1.0 0.9511627159847779 0.7187391595735081 24.69080575448257 -6.940912559243009 0.6510201792677657 1.0025733927666176 0.6543430697849012 0.9982809757236604 0.005087573218175836 0.08735283589921511 0.05273259008119448 0.004987297769489084 0.019925178628495053 1.1457436019930328e-07 6.940912559243009 -0.3482303229817164 LAAVDATVNQVLASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAAVDATVNQVLASR 15 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 81096000.0 30477000.0 12863000.0 37756000.0 False True 29509524.317266326 17999262.979658842 27866570.944279 1.0 0.6099475811993109 0.944324640569485 24.814677329452753 -10.11967481094534 7.3384134155206615 1.0000000772412916 0.7771361108843979 0.37197950619005504 0.13650886285820724 1.7243843367617092e-07 2.0800148301519286e-08 0.13217418439905385 0.04405804603829572 7.591457920161274e-11 10.11967481094534 -0.22286396635689365 LAAVDATVNQVLASR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAAVDATVNQVLASR 15 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 136850600.0 6221600.0 118760000.0 11869000.0 False True 9438622.059886057 97566350.12388496 9523086.947632486 1.0 10.336927308334538 1.0089488579170263 23.170144825895218 -6.6459461842689 2.0227637993524152 7.078069818795927 1.047898690619987 0.17781165702750346 3.9891039745009653 0.5185826604233337 4.062161611264647 1.601880320764106 4.418458018859072 2.2597157662302622e-07 6.6459461842689 -6.03017112817594 LAAVDATVNQVLASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAAVDATVNQVLASR 15 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 75640000.0 20657000.0 24338000.0 30645000.0 False True 28294451.134434957 23262666.684996694 23407282.15358632 1.0 0.8221635604263596 0.8272746498022417 24.754015816005463 -10.155326970761863 5.116014151560188 1.0000083632563854 0.8247191051141074 0.9993626976636218 0.002086593500784867 1.9905323178247437e-07 3.2862357501670005e-08 0.002020431850638342 0.0006734451564737407 6.993152986528338e-11 10.155326970761863 -0.17528925814227803 LAAVDATVNQVLASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAAVDATVNQVLASR 15 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 47390700.0 30477000.0 6505700.0 10408000.0 False True 25342975.860025153 6470652.502819662 12584264.678845221 1.0 0.25532331082815624 0.4965582869332667 24.59508260488703 -10.1960100454331 5.365250991228137 1.0000303122301724 0.37594079888214843 0.899223789820808 0.09848376659542293 3.57104476415823e-05 5.351571473701106e-06 0.09536111418431638 0.031785498991260146 6.367807917020672e-11 10.1960100454331 -0.624089513348024 LAAVDATVNQVLASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAAVDATVNQVLASR 15 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 24912700.0 6221600.0 11847000.0 6844100.0 False True 8053983.846070825 11187704.035650026 5598544.026396283 1.0 1.3890894555379574 0.6951272976699052 22.941271147987667 -6.754554872009487 1.6329176676476107 1.2275273513235216 0.6932476388063644 0.6683741604370557 0.1635489422670164 0.29216016414732904 1.5340032998438602 0.07907508470783786 0.19106928701615639 1.7597263127856322e-07 6.754554872009487 -0.5342797125171572 LAAVTYNGVDNNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAAVTYNGVDNNK 13 0 E7ES33;E7EPK1;Q16181-2;Q16181;G3V1Q4 E7ES33 SEPT7 Septin-7 0 1979970.0 0.0 354470.0 1625500.0 False True 0.0 496011.71953663026 1199732.7860452782 0.0 LACK(ub)EAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LACKEAVR 8 1 P17987;E7ERF2;F5H136;F5H676 P17987 TCP1 T-complex protein 1 subunit alpha 1 10821200.0 3585800.0 7235400.0 0.0 True False 4701018.524936595 6155906.523368299 0.0 1.0 1.3094835705739591 0.0 22.16454193498271 -6.880336906823956 1.3392689279820575 1.1616044483838028 2.2076770012814597e-18 0.9306173377328386 0.14719671883124605 0.14860231042629485 0.5357839102868818 0.08917671149543054 0.18165543118925853 1.317234488710493e-07 6.880336906823956 -1.1616044483838028 down LACK(ub)EAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LACKEAVR 8 1 P17987;E7ERF2;F5H136;F5H676 P17987 TCP1 T-complex protein 1 subunit alpha 1 7051200.0 2562400.0 0.0 4488800.0 True False 3887348.1365327258 0.0 3601586.7124890652 1.0 0.0 0.9264893665277579 21.890354885223203 -10.020314534666234 13.076566288894265 1.0000000444356305 0.46323450234344604 0.3091623331345509 0.3782377001092511 0.0 0.0 0.36622707848155395 0.12207569282718461 9.543011898843435e-11 10.020314534666234 -0.5367655420921844 LACK(ub)EAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LACKEAVR 8 1 P17987;E7ERF2;F5H136;F5H676 P17987 TCP1 T-complex protein 1 subunit alpha 1 13576500.0 3585800.0 5241400.0 4749300.0 True False 4911567.162601384 5009817.617008037 3627613.154903814 1.0 1.0200038910502478 0.7385856763857157 22.227751996505603 -6.889832746004592 1.0233985226414763 1.0151816786927341 0.7144626814099015 0.980790054279926 0.01776951283427379 0.1192778780235551 0.22265443231043386 0.01323306457392851 0.03296961170262362 1.288745773469964e-07 6.889832746004592 -0.3007189972828326 LACK(ub)EAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LACKEAVR 8 1 P17987;E7ERF2;F5H136;F5H676 P17987 TCP1 T-complex protein 1 subunit alpha 1 4836100.0 2562400.0 1210800.0 1062900.0 True False 3317077.3124552947 1143417.9156212588 869463.1062749819 1.0 0.34470644121794763 0.2621172268159788 21.661481207315653 -13.999999999999998 0.29205719176629014 6.712623167951069 0.24007425374561786 0.9996320674773722 0.006331857009533738 16.089246631867223 0.17142513216428787 55.288681007929604 0.030904965049530532 1.0000000000000041e-14 13.999999999999998 -6.472548914205451 LADFGVAGQLTDTMAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LADFGVAGQLTDTMAK 16 0 A0A087WVN8;Q13043-2;Q13043;Q13188;Q13188-2 A0A087WVN8 STK4;STK3 Serine/threonine-protein kinase 4;Serine/threonine-protein kinase 4 37kDa subunit;Serine/threonine-protein kinase 4 18kDa subunit;Serine/threonine-protein kinase 3;Serine/threonine-protein kinase 3 36kDa subunit;Serine/threonine-protein kinase 3 20kDa subunit 0 8229700.0 1765600.0 2291100.0 4173000.0 False True 1709551.9944405784 3205948.1779286657 3079966.1126834503 1.0 1.875314812508968 1.8016217831919856 20.705186870996243 -10.0935375387397 4.5929866299709 0.9999426031862618 1.8384682978743367 0.9942398739948147 0.030085053320864485 20928397.506263573 1.637367324768117 12739.84804400482 0.010298913954810642 8.06236510369009e-11 10.0935375387397 0.8385256946880749 LADFGVAGQLTDTMAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LADFGVAGQLTDTMAK 16 0 A0A087WVN8;Q13043-2;Q13043;Q13188;Q13188-2 A0A087WVN8 STK4;STK3 Serine/threonine-protein kinase 4;Serine/threonine-protein kinase 4 37kDa subunit;Serine/threonine-protein kinase 4 18kDa subunit;Serine/threonine-protein kinase 3;Serine/threonine-protein kinase 3 36kDa subunit;Serine/threonine-protein kinase 3 20kDa subunit 0 7853630.0 949030.0 1666400.0 5238200.0 False True 1299912.0375714174 1592772.93795211 4001045.0441153813 1.0 1.2252928597598303 3.0779352205941573 20.30998257161403 -6.929587277308383 0.750173373588367 0.9713911843599691 3.454304785369999 0.9964564789785431 0.05542010735468801 0.09285274909195915 0.07873455878437512 0.050366938070068 0.16801432835814786 1.1760146250038161e-07 6.929587277308383 2.4829136010100297 up LADFGVAGQLTDTQIK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LADFGVAGQLTDTQIKR 17 1 B4DR80;Q9Y6E0-2;Q9Y6E0;H0Y630;Q8NBY1;B4E0Y9;Q9P289;Q9P289-2;Q9P289-3;C9JDH9;C9J6L2;C9JCC0;C9J232;H7C279;O00506-3;O00506-2;O00506;C9JJV0 B4DR80;Q8NBY1 STK24;STK26;STK25 Serine/threonine-protein kinase 24;Serine/threonine-protein kinase 24 36 kDa subunit;Serine/threonine-protein kinase 24 12 kDa subunit;Serine/threonine-protein kinase 26;Serine/threonine-protein kinase 25 1 12610600.0 3249400.0 4298700.0 5062500.0 True False 3146249.575631634 6015193.327424358 3736479.3782554385 1.0 1.9118614664307936 1.1875978966180112 21.585201686118715 -10.212488591547771 4.737891263729619 0.9998979108373756 1.5497296815264787 0.4344358747009639 0.29567936422871277 0.0003189287877589335 5.301071341556263e-05 0.28634311810023505 0.09543010445520228 6.130718966822826e-11 10.212488591547771 0.5498317706891032 LADFGVAGQLTDTQIK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LADFGVAGQLTDTQIKR 17 1 B4DR80;Q9Y6E0-2;Q9Y6E0;H0Y630;Q8NBY1;B4E0Y9;Q9P289;Q9P289-2;Q9P289-3;C9JDH9;C9J6L2;C9JCC0;C9J232;H7C279;O00506-3;O00506-2;O00506;C9JJV0 B4DR80;Q8NBY1 STK24;STK26;STK25 Serine/threonine-protein kinase 24;Serine/threonine-protein kinase 24 36 kDa subunit;Serine/threonine-protein kinase 24 12 kDa subunit;Serine/threonine-protein kinase 26;Serine/threonine-protein kinase 25 1 55314300.0 6952300.0 11764000.0 36598000.0 True False 10547147.381211566 9664622.28744847 29364389.25852678 1.0 0.9163257076188007 2.7841072279729207 23.330349519497528 -6.896413480388258 0.9836750206844951 0.9145196276336645 2.9664800342529523 0.9846955467271581 0.10656925386418076 0.11409321813948192 0.192687296476914 0.08177154147600053 0.20917156797652597 1.2693650005893852e-07 6.896413480388258 2.051960406619288 up LADFGVAGQLTDTQIK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LADFGVAGQLTDTQIKR 17 1 B4DR80;Q9Y6E0-2;Q9Y6E0;H0Y630;Q8NBY1;B4E0Y9;Q9P289;Q9P289-2;Q9P289-3;C9JDH9;C9J6L2;C9JCC0;C9J232;H7C279;O00506-3;O00506-2;O00506;C9JJV0 B4DR80;Q8NBY1 STK24;STK26;STK25 Serine/threonine-protein kinase 24;Serine/threonine-protein kinase 24 36 kDa subunit;Serine/threonine-protein kinase 24 12 kDa subunit;Serine/threonine-protein kinase 26;Serine/threonine-protein kinase 25 1 8369600.0 1757200.0 2924100.0 3688300.0 True False 2406884.3265444664 2794903.593294388 2817199.5029229 1.0 1.1612122620396121 1.1704756526324296 21.19873537772125 -12.819506435969652 0.4218004532331774 0.000317910694961364 1.1707780694775287 0.9998382997205095 0.000995288508345628 10.990772758687035 0.2153305512523087 9.784321788431447 0.002237554307519247 1.5152823480059076e-13 12.819506435969652 1.1704601587825674 LADFGVAGQLTDTQIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LADFGVAGQLTDTQIKR 17 1 B4DR80;Q9Y6E0-2;Q9Y6E0;H0Y630;Q8NBY1;B4E0Y9;Q9P289;Q9P289-2;Q9P289-3;C9JDH9;C9J6L2;C9JCC0;C9J232;H7C279;O00506-3;O00506-2;O00506;C9JJV0 B4DR80;Q8NBY1 STK24;STK26;STK25 Serine/threonine-protein kinase 24;Serine/threonine-protein kinase 24 36 kDa subunit;Serine/threonine-protein kinase 24 12 kDa subunit;Serine/threonine-protein kinase 26;Serine/threonine-protein kinase 25 1 13248300.0 3249400.0 5761400.0 4237500.0 True False 2702020.0728275687 5730362.194651635 5123541.658013703 1.0 2.1207696612908626 1.896189339797205 21.36560696155299 -10.175420744934371 4.488751240935892 0.9997993977039956 2.0084795003797318 0.9641399736699507 0.09168453239236521 32148465.036279395 25.387719049030956 66655.75705296651 0.03138605409297268 6.676967388480026e-11 10.175420744934371 1.0086801026757362 LADFGVAGQLTDTQIK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LADFGVAGQLTDTQIKR 17 1 B4DR80;Q9Y6E0-2;Q9Y6E0;H0Y630;Q8NBY1;B4E0Y9;Q9P289;Q9P289-2;Q9P289-3;C9JDH9;C9J6L2;C9JCC0;C9J232;H7C279;O00506-3;O00506-2;O00506;C9JJV0 B4DR80;Q8NBY1 STK24;STK26;STK25 Serine/threonine-protein kinase 24;Serine/threonine-protein kinase 24 36 kDa subunit;Serine/threonine-protein kinase 24 12 kDa subunit;Serine/threonine-protein kinase 26;Serine/threonine-protein kinase 25 1 44144300.0 6952300.0 10205000.0 26987000.0 True False 8999889.400321176 9637082.779084042 22075642.91000374 1.0 1.0708001343594429 2.4528793552969588 23.101475841589977 -6.9175257957561875 0.8428707827602829 0.9667020134117306 2.663545849393782 0.9934656325715674 0.05406524329859909 0.0996496089569158 0.11331844654210581 0.045982431561141145 0.13464395282841232 1.2091333620082603e-07 6.9175257957561875 1.6968438359820515 up LADIQIEQLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LADIQIEQLNR 11 0 O60925;E5RGS4 O60925 PFDN1 Prefoldin subunit 1 0 3705300.0 1037900.0 1424100.0 1243300.0 False True 1360696.9510378987 1211629.8310983218 1114655.2425757386 1.0 0.8904479650477111 0.8191796429950939 20.375914360693873 LADK(ub)SVLVCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LADKSVLVCK 10 1 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 16208800.0 2107800.0 6420000.0 7681000.0 True False 3197686.7008209815 5274300.840311049 6162846.983298105 1.0 1.6494113819708829 1.927282926659401 21.608597164392048 -10.539187550727648 0.1792124581044983 1.685487424027001e-16 2.2124442742344486 0.9995086272520947 0.008613153122838427 2.33357910218094 0.09345184124860727 1.2263432546858932 0.19908893573161923 2.8894318074052467e-11 10.539187550727648 2.2124442742344486 LADK(ub)SVLVCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LADKSVLVCK 10 1 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 12929100.0 2107800.0 3256800.0 7564500.0 True False 2728588.650949607 3075556.2170427158 6187838.618324504 1.0 1.1271600854794865 2.267779944100773 21.379723486484497 -6.92803098336235 0.7627773601885928 0.9813295810436697 2.4906221723946924 0.9961370670493666 0.03542903925565006 0.09367277401149761 0.08278251623078987 0.031907531536005417 0.1043457741010417 1.180236432423269e-07 6.92803098336235 1.5092925913510227 up LADLEALK(ub)VADSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LADLEALKVADSK 13 1 O75792;A0A2R8Y658 O75792 RNASEH2A Ribonuclease H2 subunit A 1 6702560.0 859960.0 2183400.0 3659200.0 True False 1127415.887864487 1857645.2308265425 3280581.085524928 1.0 1.6477018381790158 2.9098233587419933 20.104588372926933 -6.960550682255827 0.4276016502511021 0.9485725015477169 3.657161935029042 0.999790081881588 0.011489676181130344 0.07950498899173172 0.020408754779250103 0.0164214244928507 0.10485483119150076 1.0950887508258447e-07 6.960550682255827 2.7085894334813254 LADLEALK(ub)VADSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LADLEALKVADSK 13 1 O75792;A0A2R8Y658 O75792 RNASEH2A Ribonuclease H2 subunit A 1 10406200.0 1064600.0 1649600.0 7692000.0 True False 1030804.8557325776 2308293.8825503592 5677234.44494634 1.0 2.239312193489707 5.507574409815536 19.975339807642115 -6.954307303243846 0.5093692994968742 0.9395369977154284 6.950578594287402 0.9994973778604063 0.042626468805498335 0.08180091302690926 0.029151077333731668 0.049150964213797645 0.26972623879757784 1.1109453532003893e-07 6.954307303243846 6.011041596571973 LADLEALK(ub)VADSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LADLEALKVADSK 13 1 O75792;A0A2R8Y658 O75792 RNASEH2A Ribonuclease H2 subunit A 1 58573100.0 2497900.0 8879200.0 47196000.0 True False 3789496.9209511047 7294637.3864937555 37867689.913258314 1.0 1.9249619510610172 9.99280134096378 21.853574903782967 -6.928524460353311 0.7588095867195755 0.870361628268044 11.588505295370382 0.996240169632426 0.24765645824169996 0.09341122620114978 0.08148784435681763 0.22367766331415864 0.7360121167533832 1.1788961235335123e-07 6.928524460353311 10.718143667102337 LADLEALK(ub)VADSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LADLEALKVADSK 13 1 O75792;A0A2R8Y658 O75792 RNASEH2A Ribonuclease H2 subunit A 1 7337000.0 1064600.0 1517800.0 4754600.0 True False 885262.0697766449 1509623.31014029 5748764.877213442 1.0 1.7052840753938254 6.4938565352335464 19.75574508307639 -6.933278588971343 0.7193700273365555 0.9352929627122232 7.5643775567921026 0.997144300728632 0.1304244894670282 0.09097086476506877 0.06959967476926868 0.1212312406622118 0.42574222284055374 1.1660613780945326e-07 6.933278588971343 6.629084594079879 LADLEALK(ub)VADSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LADLEALKVADSK 13 1 O75792;A0A2R8Y658 O75792 RNASEH2A Ribonuclease H2 subunit A 1 65074300.0 2497900.0 8620400.0 53956000.0 True False 3233580.7909702207 8140667.1620593835 44136561.63531186 1.0 2.517539436401963 13.649438343573562 21.624701225875416 -6.9317467135841175 0.732313365977312 0.8412088868670523 16.039842735359723 0.9968705288172607 0.31548019055036375 0.09174095603142002 0.0733112002438759 0.2904634896768307 0.997746308972775 1.1701816578170147e-07 6.9317467135841175 15.19863384849267 LADQCTGLQGFLVFHSFGGGTGSGFTSLLMER ddPTM_RPMI8226_Bortezomib_8h_R1 2 LADQCTGLQGFLVFHSFGGGTGSGFTSLLMER 32 0 P68363;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 5824124300.0 2096404300.0 1370690000.0 2357030000.0 False True 3180398590.7837152 1126079660.2501495 1891161987.3770497 1.0 0.35406872066707223 0.5946304946987883 31.566560439908184 -10.239354475069021 5.525669731271714 1.0000329322223938 0.4743496076829551 0.8642445795476464 0.0982089329994929 3.984606545314226e-05 5.484992300236339e-06 0.09509633056272598 0.031696796829639856 5.762958934761261e-11 10.239354475069021 -0.5256833245394387 LADQCTGLQGFLVFHSFGGGTGSGFTSLLMER ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LADQCTGLQGFLVFHSFGGGTGSGFTSLLMER 32 0 P68363;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 3893174300.0 2096404300.0 269880000.0 1526890000.0 False True 2713836692.6567755 254860940.7564133 1249011687.2144215 1.0 0.09391167178409364 0.46023833733033936 31.337686762000633 -10.620474806836203 6.479620219076374 1.0025113897941629 0.27707500564705995 0.8385179631881291 0.14955223496058212 0.005436926020566575 0.0003184519741341721 0.14510204375730307 0.04826777628253611 2.3962117485278713e-11 10.620474806836203 -0.725436384147103 LADQPLTPK(ub)SILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LADQPLTPKSILR 13 1 Q96S82;H3BV23;H3BUV9 Q96S82 UBL7 Ubiquitin-like protein 7 1 23467400.0 3030100.0 4540300.0 15897000.0 True False 2933911.1340928813 6353265.467351718 11733098.800222566 1.0 2.165459407929902 3.999132306319923 21.484393742876335 -6.96445165016166 0.3673414351341156 0.8546699622215486 5.373483522112236 0.9999013923361488 0.01225854731336196 0.07814752580931558 0.01551903352257622 0.024271353556680367 0.15595847876283858 1.0852963685363465e-07 6.96445165016166 4.518813559890688 LADQPLTPK(ub)SILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LADQPLTPKSILR 13 1 Q96S82;H3BV23;H3BUV9 Q96S82 UBL7 Ubiquitin-like protein 7 1 19203600.0 3030100.0 5360500.0 10813000.0 True False 2519662.4061903157 5331621.922524055 13073948.3063368 1.0 2.1160064576211903 5.188769842426778 21.26479901831061 -6.953361908544016 0.520630184017083 0.9480388253926364 6.494011808375135 0.999439382839142 0.04193643520855351 0.08216322343501038 0.030587996908661316 0.04746109755306459 0.2538277295045249 1.113366350648915e-07 6.953361908544016 5.545972982982499 LADQPLTPK(ub)SILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LADQPLTPKSILR 13 1 Q96S82;H3BV23;H3BUV9 Q96S82 UBL7 Ubiquitin-like protein 7 1 25696400.0 3069800.0 5443600.0 17183000.0 True False 3973916.614804585 5140658.874691022 14055870.312468736 1.0 1.293600086005783 3.5370320202755248 21.922130169976672 -6.930960818234983 0.7388651886142724 0.9670703078006525 4.009068192336162 0.9967236432444143 0.0648593853233681 0.09214228036397282 0.07525936673776315 0.05943101058293188 0.2019306130177206 1.1723011250204964e-07 6.930960818234983 3.0419978845355096 up LAEALPK(ub)QSVDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAEALPKQSVDGK 13 1 P20290;P20290-2;D6RDG3 P20290;P20290-2 BTF3 Transcription factor BTF3 1 37792100.0 16267500.0 17159100.0 4365500.0 True False 21326850.034694094 14599029.16564793 3913799.936832929 1.0 0.6845375262590828 0.18351514313956527 24.346167560273752 -7.304685593870595 0.46487168887229846 1.0170052250540036 4.81323163554806e-19 0.998936149228986 0.01096527564676526 0.10117430810093793 0.04236352724771641 0.013400977986738939 0.05504342960217203 4.95809000281864e-08 7.304685593870595 -1.0170052250540036 down LAEALPK(ub)QSVDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAEALPKQSVDGK 13 1 P20290;P20290-2;D6RDG3 P20290;P20290-2 BTF3 Transcription factor BTF3 1 36968600.0 13528000.0 16228500.0 7212100.0 True False 13098561.044852823 22708624.68050947 5323034.651637734 1.0 1.7336732334757483 0.4063831617389347 23.642904996013975 -6.756638822936626 1.6249857326283934 1.4279311377107888 0.4023001826193838 0.6771543435878884 0.3084552389812684 0.2885990828086426 1.5011323386267206 0.14982307183290147 0.3612731525891122 1.7513025380263023e-07 6.756638822936626 -1.0256309550914051 LAEALPK(ub)QSVDGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAEALPKQSVDGK 13 1 P20290;P20290-2;D6RDG3 P20290;P20290-2 BTF3 Transcription factor BTF3 1 82828000.0 41962100.0 34335900.0 6530000.0 True False 63659573.5404309 28208390.377388846 5239342.637799326 1.0 0.4431130905938819 0.08230250921288 25.923874156511065 -8.319869300058354 0.4015150807058164 1.0823042162484844 3.8598901021457013e-20 0.9969162972530183 0.02096233244692519 0.12694007544407304 0.11131418385779446 0.07506017068529403 0.08145789189156288 4.7877415664274975e-09 8.319869300058354 -1.0823042162484844 LAEALPK(ub)QSVDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAEALPKQSVDGK 13 1 P20290;P20290-2;D6RDG3 P20290;P20290-2 BTF3 Transcription factor BTF3 1 37131460.0 16267500.0 15209560.0 5654400.0 True False 22282034.362657715 14537551.347910983 4318947.176023446 1.0 0.6524337549839861 0.19383091802701533 24.409377621796644 -7.4033054860327745 0.4202495743379734 1.0289177193681611 7.964183272820795e-12 0.999009348872746 0.010391533118724606 0.11214970027323964 0.04374338869001044 0.015697955888520264 0.0606435465734749 3.9508861397590296e-08 7.4033054860327745 -1.028917719360197 down LAEALPK(ub)QSVDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAEALPKQSVDGK 13 1 P20290;P20290-2;D6RDG3 P20290;P20290-2 BTF3 Transcription factor BTF3 1 47506100.0 13528000.0 31131100.0 2847000.0 True False 11249131.39201433 30963390.585260473 3442294.5369593 1.0 2.7525139058506456 0.30600536316990284 23.42331027144825 -6.7144137006882465 1.7792906190314495 2.0725175103514033 0.3109311516498896 0.48607596111175033 0.7380139249848073 0.3662943498070994 2.263092605093218 0.32973369081549664 0.8332825698069458 1.930128836898699e-07 6.7144137006882465 -1.7615863587015137 LAEALPK(ub)QSVDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAEALPKQSVDGK 13 1 P20290;P20290-2;D6RDG3 P20290;P20290-2 BTF3 Transcription factor BTF3 1 88842700.0 41962100.0 40991100.0 5889500.0 True False 54320765.64665178 38709909.25092716 4817671.431373139 1.0 0.7126171509203157 0.08868931381989992 25.695000478603514 -7.3291341121418 0.6206174037398303 0.999509277962562 1.2856947773042246e-18 0.9957459162684354 0.024811190934275636 0.10269661136191445 0.07807185375971037 0.023232428032383075 0.06307268399107409 4.6866863275843523e-08 7.3291341121418 -0.999509277962562 down LAECCIAANK(ub)GTSEQETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAECCIAANKGTSEQETK 18 1 E9PCN5;Q9H9A5-4;Q9H9A5-3;Q9H9A5-2;Q9H9A5;Q9H9A5-6;Q9H9A5-5 E9PCN5 CNOT10 CCR4-NOT transcription complex subunit 10 1 14870200.0 1132600.0 3267600.0 10470000.0 True False 1718237.0041511767 2684471.250124671 8400599.91083598 1.0 1.5623404941455221 4.889081011839775 20.712497616936105 -6.936134101838028 0.6945939005812495 0.9590154156788447 5.692604908705419 0.9976124833962968 0.08385781490841836 0.08957528841192901 0.0629770351612008 0.07941082222775969 0.29153385005489635 1.1584196030845876e-07 6.936134101838028 4.733589493026574 up LAECCIAANK(ub)GTSEQETK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAECCIAANKGTSEQETK 18 1 E9PCN5;Q9H9A5-4;Q9H9A5-3;Q9H9A5-2;Q9H9A5;Q9H9A5-6;Q9H9A5-5 E9PCN5 CNOT10 CCR4-NOT transcription complex subunit 10 1 13448700.0 1132600.0 2325900.0 9990200.0 True False 1466173.026883732 2196461.62036958 8172086.108108323 1.0 1.498091685016219 5.5737528642697995 20.483623939028554 -6.92967837503537 0.7494279410857059 0.9372756762767311 6.403651402600822 0.9964746272802162 0.1216473385467685 0.0928052825241268 0.07850105376091158 0.11061507965400905 0.36943181231287336 1.1757679697308513e-07 6.92967837503537 5.466375726324091 up LAEEIPLK(ub)ILAHNGLVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAEEIPLKILAHNGLVGR 18 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 14655900.0 4449800.0 4685600.0 5520500.0 True False 4308543.534697371 6556584.515081207 4074515.4385499535 1.0 1.5217635524116244 0.9456827825313235 22.03876883066143 -6.66822573708893 1.94379276489624 1.3335509824848435 0.948036058669342 0.271137604651163 0.22172574168866221 0.46521555764649386 3.387070133891641 0.09189027786133419 0.24606553639138848 2.1467143673534903e-07 6.66822573708893 -0.38551492381550145 LAEEIPLK(ub)ILAHNGLVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAEEIPLKILAHNGLVGR 18 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 60144100.0 8294800.0 8781300.0 43068000.0 True False 12583818.031108221 7214208.406389951 34555590.92262498 1.0 0.573292492672402 2.746033901412175 23.5850663780692 -6.855733460876631 1.2072080206017124 0.7706481018185 2.842934221105096 0.948224618025301 0.21387767236037866 0.15126609717750553 0.42136307610604595 0.13840528597203192 0.32166066137948385 1.3940120861229754e-07 6.855733460876631 2.0722861192865962 up LAEEIPLK(ub)ILAHNGLVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAEEIPLKILAHNGLVGR 18 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 11844200.0 4449800.0 4560000.0 2834400.0 True False 3700205.859564261 4535434.374910864 3427059.9352151165 1.0 1.225724877762601 0.9261808843302274 21.819174106095705 -6.7051326930865525 1.8128771338206793 1.1394563083529887 0.9269896558552447 0.44186853607065946 0.09519477315174181 0.38491553332328693 2.462868327802431 0.041839539440089994 0.1069113432756422 1.971820179802993e-07 6.7051326930865525 -0.212466652497744 LAEEIPLK(ub)ILAHNGLVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAEEIPLKILAHNGLVGR 18 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 58001800.0 8294800.0 10748000.0 38959000.0 True False 10737782.114952475 10149864.351748673 31868861.753097232 1.0 0.9452477469825803 2.9679184595038026 23.35619270016165 -6.900678101705542 0.9569639631073211 0.9174623032651226 3.1831853741956504 0.9869008677374479 0.1076823756268037 0.11090809964072379 0.17461509760156055 0.08428500800938903 0.2200524718733587 1.2569612759619052e-07 6.900678101705542 2.2657230709305276 up LAEEK(ub)AQASSIPVGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAEEKAQASSIPVGSR 16 1 Q99426;K7EP07;A0A494C0X0;Q99426-2;K7EK42 Q99426 TBCB Tubulin-folding cofactor B 1 16574100.0 3502200.0 3499100.0 9572800.0 True False 4533666.938682854 3304372.009043896 7830648.6252226485 1.0 0.7288519544410778 1.72722185619962 22.112246978144366 -6.8343602063865925 1.3083269003516946 0.8554958415630911 1.7565583041028459 0.9143149444594203 0.12338750496493733 0.17549117852747056 0.5859288230065317 0.07401235530498217 0.1703378161546611 1.464332810940285e-07 6.8343602063865925 0.9010624625397547 LAEFLSEHPNVTLTISAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAEFLSEHPNVTLTISAAR 19 0 B0QYD3;Q9UH17-3;Q9UH17;Q9UH17-2 B0QYD3 APOBEC3B DNA dC->dU-editing enzyme APOBEC-3B 0 68455000.0 20114000.0 25985000.0 22356000.0 False True 30514408.53036972 21347773.72826836 17937326.801017094 1.0 0.6995965105147559 0.5878313775331683 24.86298729071747 -13.999999999999998 0.1373066329876209 2.4319327521054217 0.44492296132942477 0.9996138863384108 0.0034198882800117463 11.93220909597565 0.11589186863822484 4.585353303371024 0.12754107224161657 1.0000000000000041e-14 13.999999999999998 -1.987009790775997 LAEFLSEHPNVTLTISAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAEFLSEHPNVTLTISAAR 19 0 B0QYD3;Q9UH17-3;Q9UH17;Q9UH17-2 B0QYD3 APOBEC3B DNA dC->dU-editing enzyme APOBEC-3B 0 50620000.0 20114000.0 18157000.0 12349000.0 False True 26037969.50621523 17146546.98871425 10101608.71144017 1.0 0.6585208952111797 0.38795685312669753 24.63411361280992 -7.584578919448415 0.2011507682456031 1.2052714832354052 1.11914766239279e-12 0.9999338176352592 0.00203725491284051 0.13221007584472744 0.021470845491525104 0.03839521596717528 0.07317345145519626 2.6026818323216675e-08 7.584578919448415 -1.2052714832342861 down LAELLSGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAELLSGKR 9 1 O75808;A0A1B0GVE3;O75808-2 O75808 CAPN15 Calpain-15 1 4346600.0 1755700.0 1295000.0 1295900.0 True False 2301739.7022229857 1101791.0478704623 1161812.6991505646 1.0 0.4786775180557424 0.5047541640040806 21.13429326137593 -10.56778446394996 6.351601403143596 1.0009137886713018 0.4917158410299124 0.9980298683807662 0.010645746129440489 0.00013797778511090967 9.389136735146722e-06 0.01032437975421747 0.0034358997889395912 2.705300644917254e-11 10.56778446394996 -0.5091979476413894 LAELLSGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAELLSGKR 9 1 O75808;A0A1B0GVE3;O75808-2 O75808 CAPN15 Calpain-15 1 3473900.0 1755700.0 1718200.0 0.0 True False 2404829.7360084923 1642284.2426724164 0.0 1.0 0.6829108182096335 0.0 21.19750332289882 -7.463498365334146 0.7309916645373609 0.9920065172631761 2.3615802818488138e-17 0.9871744520775436 0.0472540581147353 0.11727611002047814 0.14100748942420713 0.04141137937412115 0.07473457818960429 3.439550060101345e-08 7.463498365334146 -0.9920065172631761 down LAELLSGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAELLSGKR 9 1 O75808;A0A1B0GVE3;O75808-2 O75808 CAPN15 Calpain-15 1 4953700.0 2177600.0 0.0 2776100.0 True False 2818946.12691331 0.0 2270878.285191439 1.0 0.0 0.8055770429632175 21.426724476044967 -9.736841731097929 10.369970973136793 1.0000001128332432 0.40278852148161115 0.4228967719049862 0.32887545062667395 0.0 0.0 0.31843228581338906 0.10614409527112967 1.8329822900326592e-10 9.736841731097929 -0.597211591351632 LAELQAK(ub)HGDPGDAAQQEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAELQAKHGDPGDAAQQEAK 20 1 O14737;O14737-2;K7ESJ4;Q3HM38;X6R2P6 O14737 PDCD5 Programmed cell death protein 5 1 7087170.0 2964370.0 3105700.0 1017100.0 True False 3886317.776999913 2642341.665923783 911860.2487121234 1.0 0.6799088025075418 0.23463347596244283 21.889972441569576 -7.268207632034798 0.3982434959885043 1.0314902670418662 4.568760521655718e-11 0.999562207463357 0.006566828181228401 0.097890707683743 0.02981464566096577 0.010888616843716292 0.0495199708292305 5.392527492988857e-08 7.268207632034798 -1.0314902669961785 down LAELQAK(ub)HGDPGDAAQQEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAELQAKHGDPGDAAQQEAK 20 1 O14737;O14737-2;K7ESJ4;Q3HM38;X6R2P6 O14737 PDCD5 Programmed cell death protein 5 1 4445100.0 1591400.0 1514000.0 1339700.0 True False 1540881.8780883183 2118548.0954056997 988792.379861495 1.0 1.3748932514113659 0.641705502493307 20.555324840373572 -6.767714445906423 1.5832372383367301 1.2156553480148484 0.6379362121714606 0.7217356350896831 0.15790848465425422 0.2701381898840604 1.3360089606673597 0.07863293628783735 0.1875715973720983 1.7072045285390348e-07 6.767714445906423 -0.5777191358433879 LAELQAK(ub)HGDPGDAAQQEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAELQAKHGDPGDAAQQEAK 20 1 O14737;O14737-2;K7ESJ4;Q3HM38;X6R2P6 O14737 PDCD5 Programmed cell death protein 5 1 19461700.0 8200000.0 6231600.0 5030100.0 True False 12439999.500299858 5119522.292286977 4035898.5302288476 1.0 0.41153717829036685 0.3244291553332912 23.56848309172869 -13.999999999999998 0.26901503048193576 5.518045568132052 0.29523772144151395 0.9995812148609097 0.006140301149825627 14.834918022447733 0.16418016838460708 36.634152091744724 0.036356620202573624 1.0000000000000041e-14 13.999999999999998 -5.2228078466905385 LAELQAK(ub)HGDPGDAAQQEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAELQAKHGDPGDAAQQEAK 20 1 O14737;O14737-2;K7ESJ4;Q3HM38;X6R2P6 O14737 PDCD5 Programmed cell death protein 5 1 9497490.0 2964370.0 4658200.0 1874920.0 True False 4060377.698087082 4452385.321392531 1432102.5111894917 1.0 1.0965446203416325 0.3527017971417244 21.953182503092467 -6.8742613481477 1.1112659119931816 1.056300814052061 0.3054520564029507 0.9687561521206406 0.058375720148909294 0.13283669753626076 0.3040163345303646 0.04065221894053417 0.09702757528962666 1.3357914269417576e-07 6.8742613481477 -0.7508487576491104 down LAELQAK(ub)HGDPGDAAQQEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAELQAKHGDPGDAAQQEAK 20 1 O14737;O14737-2;K7ESJ4;Q3HM38;X6R2P6 O14737 PDCD5 Programmed cell death protein 5 1 10020000.0 1591400.0 7417200.0 1011400.0 True False 1323319.6109736543 7377242.071401079 1222879.063814763 1.0 5.574799927564854 0.9240995551445123 20.33573011580785 -6.649926290270342 2.008578891868214 3.9687452630509688 0.9435676624565881 0.19381625150349102 1.9526067412589412 0.5087272078166891 3.933843500324592 0.788387955562023 2.163044126532109 2.2391011331135897e-07 6.649926290270342 -3.0251776005943807 LAELQAK(ub)HGDPGDAAQQEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAELQAKHGDPGDAAQQEAK 20 1 O14737;O14737-2;K7ESJ4;Q3HM38;X6R2P6 O14737 PDCD5 Programmed cell death protein 5 1 18367600.0 8200000.0 8355600.0 1812000.0 True False 10615061.646165088 7890603.514837303 1482234.5926900653 1.0 0.7433403382718883 0.13963504330900928 23.33960941382114 -7.20760528127342 0.5812970559234247 1.0030428896755998 6.90771123111805e-26 0.9981562582454759 0.015485527166129479 0.08839845477915748 0.05208968706875468 0.015380433143236163 0.05268863410215424 6.200043245497944e-08 7.20760528127342 -1.0030428896755998 down LAENACTLADLTEGQVGK(ub)LLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAENACTLADLTEGQVGKLLIR 22 1 P05423 P05423 POLR3D DNA-directed RNA polymerase III subunit RPC4 1 19058100.0 4114600.0 4117500.0 10826000.0 True False 5326430.810891573 3888357.5054266104 8855779.084140522 1.0 0.7300118303378001 1.6626103667829646 22.344737690249907 -6.829254286216704 1.3311640067653605 0.85565667320653 1.6873384941498382 0.9043854023249375 0.12115617291930751 0.18173603614429742 0.630069609929961 0.07146544054500917 0.16447385970663742 1.4816503016780142e-07 6.829254286216704 0.8316818209433081 LAENFCVCHLATGDMLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAENFCVCHLATGDMLR 17 0 P54819;F8W1A4;P54819-2;P54819-5;P54819-3;F8VZG5;A0A5F9ZHP2;G3V213 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 0 24881300.0 4867700.0 13238000.0 6775600.0 False True 6381601.838873856 11262942.001319854 6074525.908144592 1.0 1.7649082919449883 0.9518810576901406 22.60548716806964 -6.65996255563914 1.973249184705265 1.4923910286118798 0.9552897918704331 0.23531390576467948 0.32568634799525786 0.48455850197939815 3.6270051623370283 0.13335637116076365 0.360985648796944 2.1879502583226152e-07 6.65996255563914 -0.5371012367414467 LAENFCVCHLATGDMLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAENFCVCHLATGDMLR 17 0 P54819;F8W1A4;P54819-2;P54819-5;P54819-3;F8VZG5;A0A5F9ZHP2;G3V213 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 0 28789700.0 4867700.0 11597000.0 12325000.0 False True 6667420.234646317 11084606.193849385 9414088.841342837 1.0 1.662503007722504 1.4119537257339565 22.66869722959253 -10.220838492479784 4.999163386966296 0.9999316117015028 1.5372283667286972 0.8597502687805895 0.10228631605050592 7.797849650021653e-05 1.2153491521976092e-05 0.09905084462614903 0.033012766550461876 6.013973464393008e-11 10.220838492479784 0.5372967550271944 LAENIDAQLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAENIDAQLKR 11 1 P37198;M0QXN5 P37198 NUP62 Nuclear pore glycoprotein p62 1 12797200.0 1624500.0 1754100.0 9418600.0 True False 1572931.1367063436 2454521.277510657 6951586.108056625 1.0 1.5604759930242902 4.419510775667506 20.585024079933476 -6.939359602004302 0.6654935066955635 0.9675269053705531 5.176193287664161 0.9980788264893481 0.06563511560375342 0.08805998761047024 0.0559490100450009 0.06358505867062207 0.24677383012601373 1.1498479042541691e-07 6.939359602004302 4.208666382293608 LAENIDAQLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAENIDAQLKR 11 1 P37198;M0QXN5 P37198 NUP62 Nuclear pore glycoprotein p62 1 37712200.0 3726700.0 9772500.0 24213000.0 True False 5653676.358264327 8028521.0221089935 19427289.937065106 1.0 1.4200531677716588 3.4362225047896557 22.430757868536592 -6.940720779906796 0.6528227251746335 0.9776201232206357 3.991646393559933 0.9982568028926415 0.04439689159220018 0.08743932564843074 0.05312356123064033 0.04345682768491978 0.17298395625132815 1.146249660621087e-07 6.940720779906796 3.014026270339297 up LAENIDAQLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAENIDAQLKR 11 1 P37198;M0QXN5 P37198 NUP62 Nuclear pore glycoprotein p62 1 8328500.0 1624500.0 2837500.0 3866500.0 True False 1350843.727552283 2822213.8243003474 4674967.2733238945 1.0 2.0892230290872904 3.460775793655195 20.365429355367752 -6.968001705148907 0.3021272460669231 0.768060960180454 4.825044934477584 0.9999623325618608 0.006179167813109767 0.07695657343433544 0.011338616629137979 0.022517835482442634 0.1227340762508574 1.0764609871660967e-07 6.968001705148907 4.056983974297131 LAENIDAQLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAENIDAQLKR 11 1 P37198;M0QXN5 P37198 NUP62 Nuclear pore glycoprotein p62 1 22087800.0 3726700.0 1353100.0 17008000.0 True False 4824286.614239443 1277798.795529506 13912718.516817119 1.0 0.2648679271579624 2.8838913666016674 22.20188419062904 -6.83176065333943 1.3199855987611782 0.6076515728051514 2.956958197766769 0.9093630081583169 0.3320578480218327 0.17864362850100796 0.6081166658863402 0.1974783000820079 0.454453279329337 1.473124141120393e-07 6.83176065333943 2.3493066249616175 up LAEPYGK(ub)IK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAEPYGKIK 9 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4 P43243 MATR3 Matrin-3 1 27725700.0 8122100.0 11249600.0 8354000.0 True False 10648151.754528288 9571203.53059734 7489608.217226496 1.0 0.8988605488766669 0.7033716639173015 23.344099701613167 -6.960707338322068 0.4253509346502045 1.0081590686262596 0.5866337356325789 0.9997955301081355 0.0017605628955289735 0.07944945965095335 0.02020511245428226 0.0025386449024106506 0.016249919242601125 1.0946938083015775e-07 6.960707338322068 -0.42152533299368067 LAEPYGK(ub)IK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAEPYGKIK 9 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4 P43243 MATR3 Matrin-3 1 47869700.0 11618300.0 18166000.0 18085400.0 True False 11249483.426035887 25419778.534438524 13348291.189629827 1.0 2.259639627150061 1.1865692569257398 23.423355418915442 -6.6070760678381655 2.1645686128155925 1.843226652179856 1.1903150418332868 0.04134613217487937 0.5434793357753519 0.6208040344705537 5.50753172989852 0.2076523678483564 0.6036516964351947 2.471291253844222e-07 6.6070760678381655 -0.6529116103465691 LAEPYGK(ub)IK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAEPYGKIK 9 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4 P43243 MATR3 Matrin-3 1 76705300.0 15320600.0 17393700.0 43991000.0 True False 23242470.28588954 14289658.33740163 35296159.56805974 1.0 0.6148080716737263 1.518606203811648 24.470260075458533 -6.790898428302051 1.4927256097801695 0.7849692250216846 1.5284604940335567 0.8042335401646357 0.16384624258890115 0.23401088479623053 1.0300789543489357 0.08639182562888648 0.20213422608522416 1.6184585143776388e-07 6.790898428302051 0.743491269011872 LAEPYGK(ub)IK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAEPYGKIK 9 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4 P43243 MATR3 Matrin-3 1 22680800.0 8122100.0 4510200.0 10048500.0 True False 11125059.861499446 4310924.450763087 7675251.255353622 1.0 0.3874967419889511 0.6899065129451937 23.40730976313606 -10.52662093010498 6.3938394048188405 1.0004337826443563 0.5387016274671165 0.7562458313322965 0.12345827201245439 0.0007640932429675955 5.6570891185969464e-05 0.1196454667559141 0.03984598595464842 2.97426095507866e-11 10.52662093010498 -0.46173215517723987 LAEPYGK(ub)IK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAEPYGKIK 9 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4 P43243 MATR3 Matrin-3 1 43702100.0 11618300.0 24244000.0 7839800.0 True False 9661131.227959791 24113392.7599428 9479065.93286037 1.0 2.4959181477793666 0.9811548678096293 23.203760694349718 -6.649015461789528 2.011815749672385 1.9714367692865045 0.9874842460808443 0.19019011835991528 0.6386245492324942 0.5109225424802213 3.9625058103553323 0.25752963233737236 0.7074288195750856 2.2438020383274202e-07 6.649015461789528 -0.9839525232056602 LAEPYGK(ub)IK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAEPYGKIK 9 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4 P43243 MATR3 Matrin-3 1 56992100.0 15320600.0 19598500.0 22073000.0 True False 19832818.714175247 18507826.246533897 18055940.48810583 1.0 0.9331919236122332 0.9104071765250688 24.241386397550983 -13.999993307625545 0.15015619443099976 1.32312210197874 0.8853843847872155 0.9995656965414745 0.0007923032896446834 11.958349450849068 0.12204714614188092 1.127351062434009 0.022557613187884115 1.0000154098803889e-14 13.999993307625545 -0.43773771719152454 LAETQNIAPSFVK(ub)GFLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAETQNIAPSFVKGFLLR 18 1 Q96I63;Q96TA2-3;Q96TA2-2;Q96TA2;Q5T8D2;Q5T8D1 Q96I63 YME1L1 ATP-dependent zinc metalloprotease YME1L1 1 5094550.0 903350.0 1536500.0 2654700.0 True False 874673.64871879 2150032.462741648 1959354.430707104 1.0 2.458096760878741 2.2400977022425903 19.738385304868203 -10.017818613778841 7.242477695670985 0.9999998961335544 2.349097231560666 0.9807929210231074 0.0889977430109413 1.4945491334293194e-07 2.0388979121784747e-08 0.08617170055288327 0.028723898044285098 9.598014157953189e-11 10.017818613778841 1.3490973354271119 LAEVIQK(ub)HQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAEVIQKHQR 10 1 Q8IZ83-3;Q8IZ83;Q8IZ83-2 Q8IZ83-3 ALDH16A1 Aldehyde dehydrogenase family 16 member A1 1 5406040.0 377560.0 932280.0 4096200.0 True False 488758.8628202559 880397.7984600171 3350733.6305612796 1.0 1.8012927548360158 6.855596666271671 18.898763337943045 -6.934785694715721 0.7064033738311642 0.9350660250267119 8.032141920202735 0.9973980781617814 0.1322262404753669 0.09022789308526877 0.06605696033300573 0.12409991155392648 0.4459085386090223 1.1620218792341901e-07 6.934785694715721 7.097075895176022 LAEVTK(ub)VVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAEVTKVVVR 10 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 4253900.0 1257300.0 1201700.0 1794900.0 True False 1648332.475710519 1022411.0441899109 1609180.9658965599 1.0 0.6202699147507832 0.9762478077748953 20.65257583895737 -10.532988210635269 8.976071015370918 1.0000129677157077 0.798258862096568 0.2998348480286438 0.14532736627002166 3.771609684220722e-05 1.962231526226254e-06 0.14072165110642956 0.04690420577599828 2.93097280840365e-11 10.532988210635269 -0.20175410561913965 LAEVTK(ub)VVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAEVTKVVVR 10 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 6455100.0 1791700.0 1746900.0 2916500.0 True False 1734823.4642269951 2444446.2799631516 2152581.1568754558 1.0 1.4090461250778339 1.2408070338353452 20.72635743083531 -10.17788547585249 5.267551070147298 0.9999848205863128 1.3249265794567173 0.8325917938512306 0.06868332138938714 1.2244404611337541e-05 1.9109718945774667e-06 0.06650544448573477 0.022167446658544507 6.639181235880289e-11 10.17788547585249 0.32494175887040455 LAEVTK(ub)VVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAEVTKVVVR 10 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 17740000.0 3458100.0 5942500.0 8339400.0 True False 5246190.520974019 4882014.446035587 6691113.934711136 1.0 0.9305827583877343 1.2754233587134098 22.322838770879294 -6.8543491564303025 1.214066938740059 0.9627721005182642 1.2903978202882118 0.9463766238687434 0.03448475819633508 0.15274170351759017 0.4310778408647377 0.022199975657781725 0.05153106911463854 1.398462559195907e-07 6.8543491564303025 0.3276257197699476 LAEVTK(ub)VVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAEVTKVVVR 10 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 4525700.0 1257300.0 1251100.0 2017300.0 True False 1722157.787254927 1195822.265165557 1540855.2875976372 1.0 0.6943743912523053 0.8947236420500811 20.715785900480263 -10.17136802484015 4.848906638467496 1.0000197128083985 0.7945490176128581 0.5836980165356926 0.08179223913639042 114673547.36734506 0.23024224962756043 25238.99025808497 0.02799965900203598 6.739566690277806e-11 10.17136802484015 -0.2054706951955404 LAEVTK(ub)VVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAEVTKVVVR 10 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 6460500.0 1791700.0 2699500.0 1969300.0 True False 1489877.9357681894 2684957.257691205 2381071.524985579 1.0 1.802132371540106 1.5981655059264201 20.506762706269587 -10.037409438246204 4.540219142222246 0.999971774914841 1.7001489387652273 0.9401587270227065 0.08326912436392542 19201102.618854247 0.09244147956083627 5990.117543453365 0.028505236073836385 9.174672313482439e-11 10.037409438246204 0.7001771638503863 LAEVTK(ub)VVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAEVTKVVVR 10 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 10239900.0 3458100.0 3096700.0 3685100.0 True False 4476578.61934189 2924365.9227819275 3014449.6123190676 1.0 0.6532591453094694 0.6733824799355869 22.093965092971743 -10.183183610782027 5.305624522826113 1.0000156133179934 0.6633208126224284 0.9973278134958521 0.00821531695990365 1.5173221753956524e-06 2.3359194403660964e-07 0.007954815025123945 0.0026514821474083734 6.558679202006016e-11 10.183183610782027 -0.336694800695565 LAEYK(ub)CNTNTAIELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAEYKCNTNTAIELK 15 1 O14929;F8W9G7;F8WEW1 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 26209800.0 5348200.0 12634000.0 8227600.0 True False 7011541.992042469 10749056.446946273 7376286.876712084 1.0 1.5330517108997677 1.0520206375549872 22.741300328771622 -10.44538167500413 3.8219360101206132 0.9978093480297133 1.2925361742048294 0.3302609566932344 0.19638011415532552 141372066.51832896 7832.4548733388065 2762353.5972059285 0.06722607248853417 3.5860663855568696e-11 10.44538167500413 0.29472682617511603 LAEYK(ub)CNTNTAIELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAEYKCNTNTAIELK 15 1 O14929;F8W9G7;F8WEW1 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 16219000.0 6086000.0 4843000.0 5290000.0 True False 5892803.261307971 6776835.155911361 3904390.303401733 1.0 1.1500189053328704 0.662569261227145 22.490522670118587 -6.824085102826434 1.3542027117883628 1.0805412703522337 0.6509742514947293 0.8935040336044731 0.06652196339325334 0.1882252230056967 0.6771292828154363 0.03859125218923412 0.08886044591471287 1.499390991302909e-07 6.824085102826434 -0.42956701885750437 LAEYK(ub)CNTNTAIELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAEYKCNTNTAIELK 15 1 O14929;F8W9G7;F8WEW1 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 38128000.0 12652000.0 11820000.0 13656000.0 True False 19194008.985096805 9710628.649918484 10956885.61436257 1.0 0.5059197720214836 0.5708492489958741 24.194152737853276 -10.413313527866752 5.951555154306828 1.0001487933342952 0.5383845105089172 0.9853786492752528 0.02650734797550847 5.235039733808966e-05 5.160564141069494e-06 0.025673794311637865 0.00855520977177232 3.860881498899151e-11 10.413313527866752 -0.46176428282537796 LAEYK(ub)CNTNTAIELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAEYKCNTNTAIELK 15 1 O14929;F8W9G7;F8WEW1 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 25460800.0 5348200.0 7845600.0 12267000.0 True False 7325574.069670564 7498955.450070261 9369787.24679534 1.0 1.0236679581355315 1.279051601646928 22.804510390294514 -6.924982905282952 0.7868661395718313 0.9953112986861405 1.3253593293615833 0.9954573803878237 0.008515022833052556 0.09532740024049827 0.09105906770499163 0.007537429665477122 0.023776926006565502 1.1885490102307278e-07 6.924982905282952 0.33004803067544275 LAEYK(ub)CNTNTAIELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAEYKCNTNTAIELK 15 1 O14929;F8W9G7;F8WEW1 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 15396600.0 6086000.0 4726900.0 4583700.0 True False 5060778.655514427 4701435.251483811 5542130.4773657685 1.0 0.928994443643754 1.0951141819504082 22.270927945552863 -6.790590370891543 1.4942851821045628 0.9603452691535618 1.0969020412542914 0.8031337272633171 0.030196073077166652 0.2344755433765833 1.0343420404781243 0.015906315022180307 0.03721962687963359 1.619606940225469e-07 6.790590370891543 0.13655677210072958 LAEYK(ub)CNTNTAIELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAEYKCNTNTAIELK 15 1 O14929;F8W9G7;F8WEW1 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 33042200.0 12652000.0 11238000.0 9152200.0 True False 16378263.408204962 10612595.421004051 7486593.509502207 1.0 0.6479682953253454 0.4571054526911366 23.965279059945725 -11.303384903623229 0.10276028455918713 2.073951556550258 9.455953403279056e-15 0.9998724160370693 0.0025399434307076065 3.9443331148708864 0.06594909303514455 1.2847936776195534 0.3101837551403034 4.972961492912937e-12 11.303384903623229 -2.0739515565502487 LAFDMATNAACASLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAFDMATNAACASLLK 16 0 Q92882 Q92882 OSTF1 Osteoclast-stimulating factor 1 0 2062360.0 792060.0 1270300.0 0.0 False True 1038398.3303199499 1080776.1915906172 0.0 1.0 1.0408107948879404 0.0 19.985928538011667 -6.994766844281676 1.1298786309247741 1.0357209216869818 1.7859487873974453e-19 0.9823799441842025 0.06388964570060929 0.09318571368628083 0.23324423366154431 0.04757624844273538 0.08753856251940856 1.0121226775018844e-07 6.994766844281676 -1.0357209216869818 down LAFDMATNAACASLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAFDMATNAACASLLK 16 0 Q92882 Q92882 OSTF1 Osteoclast-stimulating factor 1 0 5692860.0 792060.0 1434000.0 3466800.0 False True 1084905.986616668 1370641.1383961376 2648013.24098721 1.0 1.2633731911375552 2.440776688167394 20.049138599534558 -6.942329573279239 0.6375215740228318 0.98712997333923 2.7812988421955143 0.9984534013838827 0.024634629457187952 0.08671973187965656 0.04988907378600906 0.02442658736901732 0.1003428384791733 1.1420113671134644e-07 6.942329573279239 1.7941688688562842 up LAFK(ub)QLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAFKQLHR 8 1 O95294-2;O95294;O95294-4;O95294-3 O95294-2 RASAL1 RasGAP-activating-like protein 1 1 9019320.0 947020.0 1442500.0 6629800.0 True False 1225936.0585550338 1362223.6069405894 5423244.427492601 1.0 1.1111701931226272 4.42375798447823 20.225452303319248 -6.9140333560515845 0.8678286533929966 0.9100513699459136 4.890931269786631 0.9923564813309766 0.1388711819049541 0.10181060085676494 0.12475080279025011 0.11601373579000444 0.32994311656132946 1.2188959778446957e-07 6.9140333560515845 3.9808798998407178 up LAFLLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAFLLFK 7 0 Q96DV4;Q96DV4-2 Q96DV4 MRPL38 39S ribosomal protein L38, mitochondrial 0 8137200.0 2821600.0 2962100.0 2353500.0 False True 3699144.9244132712 2520166.2261753683 2109982.3963661212 1.0 0.681283452709033 0.5703973322161174 21.81876039253185 -13.999999999999998 0.14723500374861906 2.5349444811263364 0.44443539142844124 0.9995757289727585 0.003750804042094781 11.948423162242381 0.12069642533483511 5.251752297616644 0.11324474284101903 1.0000000000000041e-14 13.999999999999998 -2.0905090896978953 LAFLLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAFLLFK 7 0 Q96DV4;Q96DV4-2 Q96DV4 MRPL38 39S ribosomal protein L38, mitochondrial 0 8109800.0 4093200.0 1991300.0 2025300.0 False True 3963263.606504405 2786436.474492314 1494813.1723023683 1.0 0.7030661472830843 0.377167234056579 21.91825749705119 -7.0218604988240445 0.266255526257205 1.0872543730593502 2.4908727969085065e-11 0.9999810102056014 0.0011084256195995701 0.07250991809361897 0.009349774388533185 0.006667964692519045 0.029325402230418088 9.509101896318675e-08 7.0218604988240445 -1.0872543730344415 down LAFLLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAFLLFK 7 0 Q96DV4;Q96DV4-2 Q96DV4 MRPL38 39S ribosomal protein L38, mitochondrial 0 14695900.0 2821600.0 4228200.0 7646100.0 False True 3864821.770872909 4041384.1432123766 5840248.656372532 1.0 1.0456844798562572 1.5111301381055544 21.88197045405474 -6.925891294076862 0.779763648574613 0.9917418905149243 1.5974041119120659 0.9956677401752095 0.015200149939447074 0.09482727947479136 0.08854265897393225 0.013523598643958936 0.04310499929806873 1.1860655887333193e-07 6.925891294076862 0.6056622213971415 LAFLLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAFLLFK 7 0 Q96DV4;Q96DV4-2 Q96DV4 MRPL38 39S ribosomal protein L38, mitochondrial 0 7688100.0 4093200.0 1646300.0 1948600.0 False True 3403677.1595056974 1637431.0551350366 2356043.250691565 1.0 0.48107707588014437 0.6922052651532098 21.698662772485466 -10.225868646301645 5.508416385695662 1.0000224951754797 0.5866411705166515 0.8363590366181364 0.08619272233955237 2.381286538135571e-05 3.3465986071318445e-06 0.0834602793580813 0.02781858151543379 5.94471931287108e-11 10.225868646301645 -0.41338132465882815 LAFNSLLEK(ub)AEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAFNSLLEKAEAR 13 1 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 7592800.0 3876500.0 3716300.0 0.0 True False 5082129.0400794055 3161842.526023943 0.0 1.0 0.6221492018578381 0.0 22.277001576576748 -7.5981757825915786 0.678755297153324 0.996381215886036 5.19872675231921e-21 0.9871236183853741 0.04678415491840283 0.12115944900429562 0.14649656536590117 0.04230483467760562 0.07709478661950885 2.52245958927587e-08 7.5981757825915786 -0.996381215886036 down LAFNSLLEK(ub)AEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAFNSLLEKAEAR 13 1 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 16137300.0 5450100.0 6049900.0 4637300.0 True False 5277089.558733914 8465656.619811712 3422652.0139820185 1.0 1.6042283394263264 0.6485870622220756 22.33131103738143 -6.735806393301423 1.7018325611090463 1.361239628812453 0.648497921371367 0.5860947148776708 0.25390859376751407 0.3254423827810588 1.8489757384436663 0.11810581650162619 0.2911902601727127 1.8373572471268294e-07 6.735806393301423 -0.7127417074410861 LAFNSLLEK(ub)AEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAFNSLLEKAEAR 13 1 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 28123400.0 7494200.0 10720000.0 9909200.0 True False 11369249.299408194 8806932.244257703 7950642.276643356 1.0 0.7746274193069311 0.6993111037733347 23.438633661821118 -13.999999983233836 0.15312274161747014 2.095344729550913 0.6193510892118546 0.9995561514677402 0.002691381298438832 11.970830829214846 0.12339036284281471 3.8982095594842834 0.07229930332993746 1.000000038605519e-14 13.999999983233836 -1.4759936403390583 LAFNSLLEK(ub)AEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAFNSLLEKAEAR 13 1 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 15344300.0 5450100.0 6633900.0 3260300.0 True False 4531999.630367928 6598161.863973957 3942013.6560760126 1.0 1.4559052078824393 0.8698177355667573 22.111716312815705 -6.699039118078936 1.8338287052864706 1.2833494807349124 0.8715626330491603 0.4132982263628152 0.19247510114619737 0.39748864571307313 2.598002548720961 0.08374632577247326 0.21566670501945953 1.9996817447759596e-07 6.699039118078936 -0.41178684768575213 LAFNSLLEK(ub)AEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAFNSLLEKAEAR 13 1 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 32185300.0 7494200.0 9761100.0 14930000.0 True False 9701389.632767122 9217886.2043035 12212893.194736574 1.0 0.9501614256548818 1.2588808054349938 23.209759983913568 -6.865523370766073 1.157437018841135 0.9724458083164729 1.2754927592994145 0.9600116928471848 0.02706064181522296 0.14122371014503052 0.35640806662407115 0.018188876230553153 0.042760931076862456 1.3629396601204012e-07 6.865523370766073 0.30304695098294165 LAFPSPFGHLSEGFSHSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAFPSPFGHLSEGFSHSR 18 0 Q13501;Q13501-2;E7EMC7;E9PFW8;C9JRJ8 Q13501 SQSTM1 Sequestosome-1 0 10110400.0 2885500.0 3451200.0 3773700.0 False True 3782918.443221748 2936294.4126722375 3383233.7238864796 1.0 0.7761981805168188 0.8943448754356771 21.85106824266418 -10.207236715215501 5.118288341369742 1.0000144270494888 0.8352715279761506 0.7216026009777432 0.04823318622491869 7.941250522528767e-06 1.23001832385616e-06 0.04670567053235708 0.015567193915253878 6.205307174718306e-11 10.207236715215501 -0.16474289907333828 LAFPSPFGHLSEGFSHSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAFPSPFGHLSEGFSHSR 18 0 Q13501;Q13501-2;E7EMC7;E9PFW8;C9JRJ8 Q13501 SQSTM1 Sequestosome-1 0 10138400.0 3428500.0 2110300.0 4599600.0 False True 3319664.144166018 2952953.7950691152 3394826.774957768 1.0 0.8895339006684276 1.0226416370836313 21.662605858469856 -6.686339201163581 1.8790665158761992 0.9305110839733409 1.0221672035271536 0.3535436324371336 0.04675426692695781 0.4245650056424416 2.9034304577776338 0.019924924727774542 0.052133432674831434 2.0590211081766654e-07 6.686339201163581 0.0916561195538127 LAFPSPFGHLSEGFSHSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAFPSPFGHLSEGFSHSR 18 0 Q13501;Q13501-2;E7EMC7;E9PFW8;C9JRJ8 Q13501 SQSTM1 Sequestosome-1 0 11002800.0 2885500.0 3051000.0 5066300.0 False True 3952347.327705475 2916196.7316922024 3869744.283723752 1.0 0.7378391851470182 0.9791002568517484 21.91427830418707 -10.426674523494908 7.861224574401118 1.0000044036119111 0.8584697210971112 0.3145247044189484 0.09849442007893558 7.6019758319582995e-06 5.544571302788159e-07 0.09536977884739233 0.03178893738833958 3.743910658065074e-11 10.426674523494908 -0.14153468251479995 LAFPSPFGHLSEGFSHSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAFPSPFGHLSEGFSHSR 18 0 Q13501;Q13501-2;E7EMC7;E9PFW8;C9JRJ8 Q13501 SQSTM1 Sequestosome-1 0 7508900.0 3428500.0 1567000.0 2513400.0 False True 2850949.6583028627 1558558.2599748527 3038940.3193514245 1.0 0.5466803861077801 1.0659396634735636 21.443011133904132 -6.6759801944218795 1.91597031656309 0.7121535325512002 1.0639150627392764 0.30589389547884593 0.1922983356968724 0.4475270094758787 3.1726166018480924 0.08063539769267876 0.21378755742420844 2.1087243140651786e-07 6.6759801944218795 0.3517615301880762 LAFYLCGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAFYLCGR 8 0 F8W822;R4GNG3;F8WAK2;F8VXI9;Q14161-2;Q14161-11;Q14161-7;Q14161-9;Q14161-6;Q14161-10;Q14161-8;Q14161-4;Q14161-5;Q14161-3;Q14161;J3QRU8;A0A0C4DGN6;Q9Y2X7;Q9Y2X7-3 F8W822;J3QRU8 GIT2;GIT1 ARF GTPase-activating protein GIT2;ARF GTPase-activating protein GIT1 0 9248200.0 3239400.0 2863100.0 3145700.0 False True 4246884.770394223 2435936.6402763873 2820213.139685107 1.0 0.5735819952680911 0.6640663197045765 22.01797353427601 -9.987634632499438 5.786950472226366 1.0000005279795816 0.618824157486206 0.9594510103670942 0.0369400707654622 2.516609469000813e-07 4.402332177451476e-08 0.03576711928488824 0.011922356573458474 1.0288815216122651e-10 9.987634632499438 -0.3811763704933756 LAFYLCGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAFYLCGR 8 0 F8W822;R4GNG3;F8WAK2;F8VXI9;Q14161-2;Q14161-11;Q14161-7;Q14161-9;Q14161-6;Q14161-10;Q14161-8;Q14161-4;Q14161-5;Q14161-3;Q14161;J3QRU8;A0A0C4DGN6;Q9Y2X7;Q9Y2X7-3 F8W822;J3QRU8 GIT2;GIT1 ARF GTPase-activating protein GIT2;ARF GTPase-activating protein GIT1 0 35939000.0 11293000.0 12214000.0 12432000.0 False True 17132306.62888857 10034316.271582436 9974809.750860836 1.0 0.5856955802240037 0.5822222288527844 24.030216067707588 LAFYLCGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAFYLCGR 8 0 F8W822;R4GNG3;F8WAK2;F8VXI9;Q14161-2;Q14161-11;Q14161-7;Q14161-9;Q14161-6;Q14161-10;Q14161-8;Q14161-4;Q14161-5;Q14161-3;Q14161;J3QRU8;A0A0C4DGN6;Q9Y2X7;Q9Y2X7-3 F8W822;J3QRU8 GIT2;GIT1 ARF GTPase-activating protein GIT2;ARF GTPase-activating protein GIT1 0 45748000.0 11293000.0 18769000.0 15686000.0 False True 14619011.118310038 17724488.650723 12831308.951951638 1.0 1.212427332278543 0.8777138787370278 23.801342389800038 -6.735221167002249 1.7038403290620054 1.1270948893030623 0.8777052025764756 0.5832800990445155 0.08927028039746235 0.3266206184592672 1.859782565182973 0.04147749666968437 0.10233471688006489 1.8398348162263924e-07 6.735221167002249 -0.2493896867265868 LAGANPAVITCDELLLGHEK(ub)APAFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAGANPAVITCDELLLGHEKAPAFR 25 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 49395700.0 5335800.0 8429900.0 35630000.0 True False 6907298.284342407 7960768.654522336 29145705.594672706 1.0 1.1525155461387784 4.219552188840713 22.719690095572492 -6.917237297018329 0.8449692715057123 0.9253580429654469 4.684011912346566 0.9933783378773291 0.12068280418252911 0.09982461474410548 0.11424079440155745 0.10248720658661489 0.2993356888737553 1.2099368475528228e-07 6.917237297018329 3.7586538693811193 up LAGATLLIFANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAGATLLIFANK 12 0 P36404 P36404 ARL2 ADP-ribosylation factor-like protein 2 0 4104600.0 1161300.0 1583900.0 1359400.0 False True 1522475.546045198 1347588.2939938428 1218742.3282855777 1.0 0.8851296807323804 0.800500429350999 20.537987625119065 -6.974468984210147 0.10672773448308875 1.1873762059427673 0.49609851057012766 0.9999996596828994 4.7343408490614676e-05 0.07487744292811087 0.003147209470643851 0.00700060978838058 0.013236642307900432 1.0605496764088754e-07 6.974468984210147 -0.6912776953726396 LAGATLLIFANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAGATLLIFANK 12 0 P36404 P36404 ARL2 ADP-ribosylation factor-like protein 2 0 9102800.0 3645100.0 2434300.0 3023400.0 False True 3529388.2957268604 3406328.6847067955 2231480.8399441983 1.0 0.9651328783605202 0.6322571088723565 21.750986730386224 -6.9269638550385455 0.7713079065275239 1.0056726290571147 0.568919510252113 0.9959070945907903 0.010603974675423856 0.09424536259099237 0.08563064193395542 0.009491632557122466 0.0306377557834996 1.1831400206440005e-07 6.9269638550385455 -0.4367531188050018 LAGATLLIFANK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAGATLLIFANK 12 0 P36404 P36404 ARL2 ADP-ribosylation factor-like protein 2 0 67903000.0 25285000.0 21754000.0 20864000.0 False True 38359193.5811076 17871828.73522223 16740221.254983937 1.0 0.46590731104483746 0.43640701725358255 25.19306905535053 -13.910380838712882 0.4131196745654271 9.999553644635906 0.43517366026607623 0.999854227091012 0.003127155069632521 26.62860979045851 0.2132507180247899 215.24740398050446 0.007289096357060648 1.2291904043517616e-14 13.910380838712882 -9.56437998436983 LAGATLLIFANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAGATLLIFANK 12 0 P36404 P36404 ARL2 ADP-ribosylation factor-like protein 2 0 6650500.0 1161300.0 1751400.0 3737800.0 False True 1590663.9929524767 1674017.3568946994 2855008.6224074042 1.0 1.0524016161247909 1.7948533663027988 20.601197686641957 -6.921136773839346 0.8162508967276301 0.9842800451787191 1.9177682030199352 0.9944909475404234 0.02694125725829849 0.09750742494089427 0.10218187000254775 0.023353500576993768 0.07073350562806648 1.199121600229989e-07 6.921136773839346 0.9334881578412161 LAGATLLIFANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAGATLLIFANK 12 0 P36404 P36404 ARL2 ADP-ribosylation factor-like protein 2 0 7022900.0 3645100.0 1633700.0 1744100.0 False True 3031062.155309831 1624898.9338359411 2108783.2461927333 1.0 0.5360823535041782 0.6957241845069246 21.5313920058205 -10.250481559236587 6.404030244149261 1.0000060883813613 0.6159032690055514 0.8852998850257388 0.06517350459339274 5.665425084818896e-06 6.631184913064353e-07 0.06310497353388327 0.02103465815868181 5.6171812920256905e-11 10.250481559236587 -0.3841028193758099 LAGATLLIFANK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAGATLLIFANK 12 0 P36404 P36404 ARL2 ADP-ribosylation factor-like protein 2 0 64881000.0 25285000.0 20709000.0 18887000.0 False True 32731930.941863973 19556525.945325945 15449759.796985244 1.0 0.5974754737219993 0.47200881073670725 24.96419537744298 -13.999999999999998 0.1632129551620535 2.99643067940377 0.3529392113979206 0.9995282883451573 0.004891672664335588 12.032654825162428 0.12777012050969722 7.603519963768977 0.10897594624081931 1.0000000000000041e-14 13.999999999999998 -2.643491468005849 LAGCTVFITGASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAGCTVFITGASR 13 0 Q6YN16;Q6YN16-2 Q6YN16 HSDL2 Hydroxysteroid dehydrogenase-like protein 2 0 9551000.0 3603600.0 0.0 5947400.0 False True 4724354.497312046 0.0 5332020.09948922 1.0 0.0 1.1286240485388872 22.171685792383904 -10.689469413723115 4.3749008669251275 1.019082489987462 0.5643120242693495 0.1657608140865523 0.46075883839272275 0.08631794503746011 0.0061268438201465 0.4490366888767188 0.14870927564269648 2.0442339012264848e-11 10.689469413723115 -0.4547704657181125 LAGCTVFITGASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAGCTVFITGASR 13 0 Q6YN16;Q6YN16-2 Q6YN16 HSDL2 Hydroxysteroid dehydrogenase-like protein 2 0 7744300.0 3603600.0 4140700.0 0.0 False True 4935948.303628302 3957750.1825361904 0.0 1.0 0.8018216438018484 0.0 22.234895853906796 -7.247881386439078 0.8546790154513061 0.9893244757116516 1.121801360708804e-16 0.9888449422269938 0.04566174601932103 0.09816353141600437 0.1382346875633446 0.03868450261189303 0.06810837343510844 5.650912902379095e-08 7.247881386439078 -0.9893244757116515 down LAGDK(ub)YQAAVQALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAGDKYQAAVQALR 14 1 P34896-2;P34896;P34896-3;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 1 14795000.0 2612500.0 3971600.0 8210900.0 True False 2529567.617510199 5557480.591620389 6060218.9682800155 1.0 2.197008118363921 2.3957529050933073 21.270459373459598 -10.579107221446932 0.36402041939208873 9.900033517701842e-14 2.426135003095924 0.9992212647207245 0.01720344919324209 2.111880644920247 0.17450574975781666 1.9795129658481454 0.05634238797926194 2.635680591522045e-11 10.579107221446932 2.426135003095825 LAGDK(ub)YQAAVQALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAGDKYQAAVQALR 14 1 P34896-2;P34896;P34896-3;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 1 71327100.0 6476100.0 11372000.0 53479000.0 True False 9824717.1663283 9342577.750158466 42908852.20932158 1.0 0.950925873182157 4.36743892805186 23.227984445030394 -6.903643548316468 0.9379597431918769 0.8718026231690389 4.753803298434188 0.988293097627334 0.17302210733869977 0.10877237864359457 0.16268582603254905 0.13734642746369313 0.3643427712331215 1.2484077374146913e-07 6.903643548316468 3.8820006752651492 up LAGDK(ub)YQAAVQALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAGDKYQAAVQALR 14 1 P34896-2;P34896;P34896-3;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 1 12220000.0 2975100.0 2194300.0 7050600.0 True False 4075074.8690544297 2097348.570420256 5385393.4916650485 1.0 0.5146773096973601 1.321544674568068 21.958395134734467 -6.743819279562578 1.6725537620834803 0.7125193456573334 1.3224377617960075 0.6220134228192111 0.20390442131810643 0.310956925767921 1.709376975863433 0.09638592871292236 0.23555272142005532 1.8037681762742332e-07 6.743819279562578 0.609918416138674 LAGDK(ub)YQAAVQALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAGDKYQAAVQALR 14 1 P34896-2;P34896;P34896-3;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 1 12837800.0 2612500.0 3491600.0 6733700.0 True False 2172409.5033735526 3472790.0577716613 8141685.536888952 1.0 1.5985890562431886 3.7477674095264555 21.050864648893874 -6.947358613577766 0.5871265335813102 0.974937671280013 4.4790300011323465 0.99897736284571 0.03772869360397797 0.08456405016656064 0.040487909798356245 0.03923150101901727 0.17989472835096487 1.128863384005496e-07 6.947358613577766 3.5040923298523334 LAGDK(ub)YQAAVQALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAGDKYQAAVQALR 14 1 P34896-2;P34896;P34896-3;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 1 58664100.0 6476100.0 11321000.0 40867000.0 True False 8383439.113015836 10690976.3980412 33429625.330830496 1.0 1.2752494834062504 3.987578949422895 22.999110767122843 -6.926437103714638 0.7754822649565445 0.952852235032309 4.497036394547474 0.9957904369492165 0.08747097492069711 0.0945304333320938 0.08705669731773202 0.07806189481594891 0.25039871084792026 1.184575909654794e-07 6.926437103714638 3.544184159515165 up LAGIINFQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAGIINFQR 9 0 O00232;O00232-2 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 0 17032800.0 4957400.0 5762300.0 6313100.0 False True 6499199.407529884 4902587.301269479 5659880.971531316 1.0 0.7543371104430814 0.8708581806205015 22.631830582554116 -10.155014880973859 5.168443514025568 1.0000080448355448 0.8125976455316317 0.7752250494618742 0.04756952770350828 4.409864323658175e-06 7.210608787921498e-07 0.04606097376648336 0.015352999048473282 6.998180165310582e-11 10.155014880973859 -0.18741039930391312 LAGIINFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAGIINFQR 9 0 O00232;O00232-2 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 0 13026500.0 4862100.0 2257100.0 5907300.0 False True 4707755.296878986 3158371.8006210085 4360000.914798683 1.0 0.6708869942146007 0.9261315934770765 22.16660790219966 -10.417571121507297 5.816466228762015 1.0000825234007067 0.7985092938458385 0.45381304363689157 0.10420317129904025 0.00011155685111485743 1.1170827973470454e-05 0.10093548525499524 0.033631428921931716 3.823216382694562e-11 10.417571121507297 -0.20157322955486823 LAGIINFQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAGIINFQR 9 0 O00232;O00232-2 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 0 16770400.0 4957400.0 6247500.0 5565500.0 False True 6790284.748697663 5971464.792280255 4251043.525070467 1.0 0.8794130162841178 0.6260479026134791 22.695040644077007 -6.959068885965647 0.4483628511403995 1.0083086027433403 0.48713553239769336 0.9997340922036383 0.002541228249790677 0.0800354108119436 0.02237297816234601 0.0033783449265840076 0.020962682215821135 1.0988315335689131e-07 6.959068885965647 -0.521173070345647 LAGIINFQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAGIINFQR 9 0 O00232;O00232-2 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 0 11130700.0 4862100.0 1983500.0 4285100.0 False True 4043051.577551219 1972814.4918060764 5181094.597936171 1.0 0.48795184873722625 1.2814812026400706 21.947013177633938 -6.732505108265162 1.714250196636215 0.6927081948865061 1.2812141687704146 0.570747200436134 0.21521393036083278 0.3315748965537758 1.910047545243875 0.0994461804739909 0.24605763938930297 1.851377117781103e-07 6.732505108265162 0.5885059738839085 LAGIINFQRPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAGIINFQRPK 11 1 O00232;O00232-2 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 0 61935000.0 17601000.0 20598000.0 23736000.0 False True 23075081.448326454 17524858.690375153 21280026.41178937 1.0 0.7594711520139039 0.9222080736504931 24.45983240438548 -10.118519915708077 4.7578876935063645 1.000010182437021 0.8408396129884098 0.5605112175347523 0.06643707005889803 7.176387732126297e-06 1.3294435592292944e-06 0.06433153095180347 0.021442472158309793 7.611672328933283e-11 10.118519915708077 -0.15917056944861108 LAGIINFQRPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAGIINFQRPK 11 1 O00232;O00232-2 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 0 49633800.0 15448000.0 6603800.0 27582000.0 False True 14957611.695807667 9240731.778362058 20357446.757736605 1.0 0.6177946029279566 1.3610091752443612 23.83437650055464 -6.766916762585277 1.5861676827831754 0.779914799059856 1.3647192542144446 0.7186540010691952 0.16095994996718016 0.2714483066994233 1.3473115954886548 0.08000834432234707 0.19100368343175725 1.7103430901393266e-07 6.766916762585277 0.5848044551545887 LAGIINFQRPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAGIINFQRPK 11 1 O00232;O00232-2 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 0 35938800.0 9325800.0 11955000.0 14658000.0 False True 14147920.407304456 9821536.845158676 11760839.875170358 1.0 0.6942035693166535 0.8312769323397049 23.754086672140915 -10.152598993890816 4.948904103310245 1.0000151885982154 0.762740250827557 0.7997865067073254 0.055959966124446876 78311664.94019093 0.4716129464692429 13554.074927247677 0.01915658485191386 7.037218019986948e-11 10.152598993890816 -0.23727493777065833 LAGIINFQRPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAGIINFQRPK 11 1 O00232;O00232-2 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 0 64131000.0 17601000.0 13054000.0 33476000.0 False True 24108565.349140204 12477231.116194693 25569658.25986148 1.0 0.5175434927586712 1.0606047224113808 24.52304246590837 -6.672332082669006 1.9293033177040744 0.6926694047554962 1.0584253597605748 0.2893830161400276 0.20482736962489656 0.45575358962516066 3.2727700760743863 0.08540673650724605 0.22747737450132519 2.1265123894231752e-07 6.672332082669006 0.3657559550050786 LAGIINFQRPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAGIINFQRPK 11 1 O00232;O00232-2 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 0 36092500.0 15448000.0 8514500.0 12130000.0 False True 12845696.462436218 8468630.69850408 14666326.917216824 1.0 0.6592581977371418 1.1417307703093056 23.614781775988916 -6.716956431228128 1.7702505005002795 0.7920260194188299 1.1408540228639286 0.49812176302135236 0.14344151056315327 0.361266009367182 2.2108564728792963 0.06437987445161088 0.16219999120631143 1.9188612327174958e-07 6.716956431228128 0.3488280034450987 LAGIINFQRPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAGIINFQRPK 11 1 O00232;O00232-2 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 0 47509800.0 9325800.0 24275000.0 13909000.0 False True 12072431.93900079 22924074.910560045 11377704.718391895 1.0 1.8988779581769524 0.9424534158387315 23.525212994233364 -6.660200340557684 1.9726578937086339 1.578514657502297 0.946477281802772 0.2363017395396958 0.38270594806105285 0.48393951395065343 3.6205326511794653 0.15674710185328825 0.42413041293237236 2.18675263966798e-07 6.660200340557684 -0.632037375699525 LAGLEYVLHFTALNGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAGLEYVLHFTALNGK 16 0 Q5VXN0;Q9H7B2 Q5VXN0 RPF2 Ribosome production factor 2 homolog 0 13464600.0 4485500.0 4628200.0 4350900.0 False True 6804831.433975006 3802261.5497083548 3490942.707932785 1.0 0.5587591091124624 0.5130094318726671 22.698127993745526 -13.999999999999961 0.32023202448637994 5.530466648780715 0.503950221632344 0.9996942241721506 0.0038397050043377855 18.031318579573384 0.18047783119140345 54.73698053364467 0.015217856245604613 1.00000000000009e-14 13.999999999999961 -5.026516427148371 LAGLEYVLHFTALNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAGLEYVLHFTALNGK 16 0 Q5VXN0;Q9H7B2 Q5VXN0 RPF2 Ribosome production factor 2 homolog 0 4485500.0 4485500.0 0.0 0.0 False True 5806568.172423602 0.0 0.0 1.0 0.0 0.0 22.469254315837976 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 LAGLLQHPDPIVINHVISVDPNDQKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAGLLQHPDPIVINHVISVDPNDQKK 26 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925;J3QWB6 J3KMX2 SMARCD2 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2 1 12089500.0 5086900.0 3908400.0 3094200.0 True False 6967664.398303579 3735713.9646495627 2363413.6870493283 1.0 0.5361501001051513 0.3391974056076452 22.732243706670374 -13.999999999999961 0.11711047575870889 3.216370616847563 0.012252089187000733 0.9997072303493806 0.004739766962126519 11.975756816742097 0.10493542101791511 6.202437837239248 0.2901106733014057 1.00000000000009e-14 13.999999999999961 -3.2041185276605626 LAGLSAALLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAGLSAALLR 10 0 C9J8Q5;P51649;P51649-2;A0A5F9ZH98 C9J8Q5 ALDH5A1 Succinate-semialdehyde dehydrogenase, mitochondrial 0 4049300.0 1073300.0 1595900.0 1380100.0 False True 1407106.6938519855 1357797.940769478 1237300.4908539986 1.0 0.9649573459511277 0.8793224396274182 20.424300294384235 -6.9559479976714975 0.4892133191144742 1.0018874857966682 0.8387658632270711 0.9995891205799257 0.0010274585426369256 0.08118169261532464 0.026731460865479235 0.0012308799291897853 0.007062915083519108 1.1067562988066873e-07 6.9559479976714975 -0.16312162256959706 LAGLSAALLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAGLSAALLR 10 0 C9J8Q5;P51649;P51649-2;A0A5F9ZH98 C9J8Q5 ALDH5A1 Succinate-semialdehyde dehydrogenase, mitochondrial 0 3938890.0 1073300.0 939390.0 1926200.0 False True 1470128.014841895 897884.643652684 1471271.2313342427 1.0 0.6107526926825124 1.0007776305742127 20.487510355907126 -10.935529774369938 10.708251209615208 1.0396244965158923 0.8057651616284003 0.24850465791621057 0.15922701413256096 0.09293223699025041 0.0005595082745827303 0.09511911946926305 0.051390297833478454 1.1600326838774239e-11 10.935529774369938 -0.233859334887492 LAGPQLVQMFIGDGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAGPQLVQMFIGDGAK 16 0 E9PMD8;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 0 10243600.0 4457700.0 3761800.0 2024100.0 False True 5844087.868428208 3200554.1033815555 1814665.548538207 1.0 0.5476567388166869 0.31051305000762575 22.478546439182324 -9.6979765105148 0.16505075495923358 1.6090673152245032 3.5407216346139265e-13 0.999688104595002 0.005051190851552311 1.1609372453098568 0.06943501060438581 0.5008731309052342 0.17534855189890547 2.0045804452505125e-10 9.6979765105148 -1.609067315224149 LAGPQLVQMFIGDGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAGPQLVQMFIGDGAK 16 0 E9PMD8;P17980;R4GNH3;E9PM69;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 0 15188200.0 4457700.0 4201800.0 6528700.0 False True 6105832.154812928 4016150.582505504 4986755.522797157 1.0 0.6577564663875946 0.8167200467288217 22.541756500705215 -10.077325103445878 4.708744817884777 1.0000108075097647 0.7372382565534866 0.7846253422202761 0.06489660994102879 16154471.31964082 34572665.991290785 1208.5169896048878 0.02221583584081383 8.369025604447403e-11 10.077325103445878 -0.26277255095627805 LAGTQPLEVLEAVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAGTQPLEVLEAVQR 15 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 33990970.0 918970.0 21703000.0 11369000.0 False True 1204778.569318139 18464996.997631416 10192644.939148692 1.0 15.326465350460156 8.460181147575824 20.200336581918908 -10.21161126191577 7.383214323659972 0.9999835446717967 11.893323249017989 0.7704291515731042 2.803148787666557 0.0007592909730409536 8.107173257561735e-05 2.7141411342190063 0.9047123809645071 6.14311631030014e-11 10.21161126191577 10.893339704346193 LAGTQPLEVLEAVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAGTQPLEVLEAVQR 15 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 33122900.0 10307000.0 7709900.0 15106000.0 False True 9979809.92676655 10788503.276597362 11149285.429713916 1.0 1.0810329410845632 1.1171841459435765 23.250580907900474 -13.999999999999957 0.10923265977244186 0.6084706988618043 1.1842408224774343 0.999746947920581 0.0007793860966072453 12.01709597116752 0.10016421128409672 1.0391636836999902 0.059571657929898804 1.0000000000000981e-14 13.999999999999957 0.5757701236156301 LAGTQPLEVLEAVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAGTQPLEVLEAVQR 15 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 32750970.0 918970.0 16130000.0 15702000.0 False True 1258738.0432304628 15417323.265222965 11993510.992840974 1.0 12.248238104932053 9.528202517865012 20.2635466434418 -9.706762198530424 10.047930883291583 0.9999994616567703 10.888220311398532 0.946296639180447 1.110449878421033 0.0 0.0 1.075188471480658 0.35839615716021933 1.9644356250769926e-10 9.706762198530424 9.888220849741762 LAGVTALSCWLPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAGVTALSCWLPLR 14 0 O75608;O75608-2;A0A087X1K9;E5RGR0;E5RJ48 O75608 LYPLA1 Acyl-protein thioesterase 1 0 12095800.0 3408600.0 8687200.0 0.0 False True 4412499.893551023 8203749.68333746 0.0 1.0 1.859206771954248 0.0 22.07316481290382 -6.789580604707772 1.5539915619598643 1.4854036330239568 4.964028198559086e-19 0.7707093577893822 0.36379768024372106 0.24334465566856794 1.1697724730140284 0.1858923310198643 0.42525630106726403 1.6233770250456486e-07 6.789580604707772 -1.4854036330239568 LAHEVGWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAHEVGWK 8 0 P40429;M0QYS1;Q8J015 P40429 RPL13A;RPL13a 60S ribosomal protein L13a 0 3901770.0 663970.0 1689600.0 1548200.0 False True 870471.0998946268 1437518.266009216 1388007.1153830593 1.0 1.6514256087114576 1.5945470395870487 19.731436874862496 -10.14006938621467 4.552718071736752 0.9999259774731118 1.6229863241626417 0.9937870917105776 0.02322057867676043 16227654.421689877 1.9144371647346672 12888.377755923853 0.00794902170190787 7.243202278796293e-11 10.14006938621467 0.6230603466895298 LAHEVGWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAHEVGWK 8 0 P40429;M0QYS1;Q8J015 P40429 RPL13A;RPL13a 60S ribosomal protein L13a 0 3879570.0 663970.0 1923300.0 1292300.0 False True 909457.6521145748 1838322.2464974157 987085.3557539427 1.0 2.0213390279614925 1.0853560398979285 19.794646936385387 -6.625429650478508 2.097286538334945 1.6750984454167284 1.0890586003491185 0.10126829459353215 0.43860784148335613 0.5709401023770023 4.779624860244039 0.17141488788437617 0.48597504522912954 2.3690288496423419e-07 6.625429650478508 -0.5860398450676099 LAHGGQVNLDMEDHRDEDFVK(ub)PK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAHGGQVNLDMEDHRDEDFVKPK 23 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 12723100.0 4692200.0 3541200.0 4489700.0 True False 6151519.639329441 3012866.7634894834 4025148.912243454 1.0 0.4897760131052605 0.6543340748697054 22.552511419663148 -10.408288026364817 5.222731528506358 1.00034756427585 0.57205504398747 0.9001726415918564 0.06718054739742765 0.00027209649945286144 3.0827317683241395e-05 0.06509896477133098 0.021682428438271267 3.9058177400741884e-11 10.408288026364817 -0.42829252028837994 LAHGGQVNLDMEDHRDEDFVK(ub)PK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAHGGQVNLDMEDHRDEDFVKPK 23 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 23438200.0 9821600.0 6340100.0 7276500.0 True False 9509818.684072027 8871734.99318472 5370566.359679158 1.0 0.9329026438794219 0.5647390910485294 23.1809864039869 -6.9377556566810235 0.6801282244500422 1.0043369064118635 0.47168806955134185 0.9978548159458243 0.0088621207794254 0.08880582851107424 0.059386526557546115 0.008486368171156692 0.032013101138033705 1.1541023977667178e-07 6.9377556566810235 -0.5326488368605216 LAHGGQVNLDMEDHRDEDFVK(ub)PK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAHGGQVNLDMEDHRDEDFVKPK 23 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 65005000.0 10826000.0 26920000.0 27259000.0 True False 16423833.486615408 22115915.673079975 21871246.701955844 1.0 1.346574518738474 1.3316773285469437 23.969287570050525 -10.05805473247903 4.62550706312319 0.9999850931593601 1.339125923654956 0.9985548253962431 0.0060817524702632166 9.349564316630212e-07 1.9040307849614995e-07 0.005888890202928677 0.0019628771635147066 8.748735113038707e-11 10.05805473247903 0.33914083049559585 LAHGGQVNLDMEDHRDEDFVK(ub)PK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAHGGQVNLDMEDHRDEDFVKPK 23 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 14436100.0 4692200.0 6905000.0 2838900.0 True False 6427033.141937151 6599914.268218499 2168410.288980783 1.0 1.0268990562929072 0.33738900066216393 22.61572148118604 -6.897818697954341 0.9749234563820693 1.030408141401622 0.26812794690838704 0.9854504272364321 0.03846467849983693 0.11302988044020633 0.186599422183694 0.02970706080293406 0.07648312475973255 1.2652644388129977e-07 6.897818697954341 -0.7622801944932349 down LAHGGQVNLDMEDHRDEDFVK(ub)PK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAHGGQVNLDMEDHRDEDFVKPK 23 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 21872000.0 9821600.0 8846200.0 3204200.0 True False 8167095.570654041 8798543.764766779 3874183.4054531017 1.0 1.0773161264797309 0.4743648916481147 22.961391679421176 -6.87469545437778 1.1090248616102947 1.0452465173686707 0.43576409427671414 0.9691456735367502 0.047053572655169816 0.13242917088662412 0.3016040772099478 0.03282576389660035 0.0784113590632492 1.334456881629303e-07 6.87469545437778 -0.6094824230919565 down LAHGGQVNLDMEDHRDEDFVK(ub)PK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAHGGQVNLDMEDHRDEDFVKPK 23 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 84129000.0 10826000.0 29074000.0 44229000.0 True False 14014470.412363818 27456006.341900002 36179775.82786359 1.0 1.9591183636648746 2.581601356548239 23.740413892142975 -8.404215861966517 0.1611925734063541 2.8142421518340363e-19 3.6279652325316367 0.9998778899163806 0.007188721259885609 0.11975023406110043 0.03840485519660207 0.39628619549962846 0.3653552382260297 3.942612895195137e-09 8.404215861966517 3.6279652325316367 LAHGGQVNLDMEDHRDEDFVKPKGAFK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAHGGQVNLDMEDHRDEDFVKPKGAFK 27 3 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 24035400.0 8220300.0 12227000.0 3588100.0 True False 11259567.055254657 11686770.710717984 2740664.6792391283 1.0 1.0379413927166905 0.24340764309939472 23.424648019227778 -6.89568869146061 0.9881376631017665 1.0370537282759629 0.16694489609738256 0.9842960560508242 0.04585689445176872 0.11464815485915464 0.19586394419663833 0.03506910203732413 0.08942040301536693 1.271485197529153e-07 6.89568869146061 -0.8701088321785804 down LAHLGVQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAHLGVQVK 9 0 P04843;F8WF32 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 26747100.0 11427000.0 7608500.0 7711600.0 False True 14980907.659225402 6473341.457700707 6913677.606890576 1.0 0.4321060916301927 0.461499247185671 23.836621700277455 -10.721690457190931 6.8150285923431495 1.007017663615876 0.4468026694080851 0.9978871189157342 0.011999705506862409 0.0012801694644657957 5.227899563123684e-05 0.011624946952218874 0.0038728882989559604 1.8980582776986264e-11 10.721690457190931 -0.560214994207791 LAHLGVQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAHLGVQVK 9 0 P04843;F8WF32 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 9072700.0 3417400.0 1222500.0 4432800.0 False True 3308916.5075901877 1710650.625253281 3271716.6988505144 1.0 0.5169821061756288 0.9887577070456923 21.65792745855539 -10.856181836633885 10.495462696992881 1.0076469361601543 0.7528699066106606 0.2678624024670687 0.1926015825377652 0.03435741588949807 0.00047079494344345863 0.1859152245908662 0.062161893468496474 1.392573618198087e-11 10.856181836633885 -0.25477702954949377 LAHLGVQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAHLGVQVK 9 0 P04843;F8WF32 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 22024300.0 11427000.0 3871000.0 6726300.0 False True 15651870.703063749 3699966.4203148163 5137686.472496905 1.0 0.2363913228334152 0.328247438914202 23.899831761800346 -10.64509155063564 6.663085601498506 1.0030984596081323 0.2823193809300534 0.9878629900277165 0.03750010235863136 0.0017295926617509072 9.212640035451075e-05 0.03638366019571866 0.01210310599300439 2.264166963801776e-11 10.64509155063564 -0.7207790786780789 LAHLGVQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAHLGVQVK 9 0 P04843;F8WF32 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 6627800.0 3417400.0 2110400.0 1100000.0 False True 2841719.5164894885 2099030.8563184002 1330004.9141746496 1.0 0.7386481474116182 0.4680282154720421 21.438332733989665 -6.970687873097959 0.2411943378954839 1.0957440519939226 0.10309347448401593 0.9999872603732465 0.0007751776615507489 0.07608015830251982 0.008227534084122695 0.00641451637336474 0.026326907091669172 1.0698234837944095e-07 6.970687873097959 -0.9926505775099066 down LAHLLASAQK(ub)EPEAAAPAPGTGGDSVCGETHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAHLLASAQKEPEAAAPAPGTGGDSVCGETHR 32 1 Q08379;Q08379-2;A0A1W2PQY5;A0A087WYC0 Q08379 GOLGA2 Golgin subfamily A member 2 1 26277200.0 3612100.0 7478100.0 15187000.0 True False 4675934.655135729 7061937.161221784 12423121.831779249 1.0 1.510272850683538 2.656821095250879 22.15682333807947 -6.957706371176364 0.4666435830540959 0.9687074952012686 3.245123978943536 0.9996754205208251 0.012481922271491882 0.08053096600799071 0.024238176264032574 0.015754736026451267 0.09465552411813648 1.1022843179879486e-07 6.957706371176364 2.2764164837422673 LAILHLINGTIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAILHLINGTIK 12 0 Q69YN4-2;Q69YN4-3;Q69YN4;H0YBN5 Q69YN4-2 KIAA1429 Protein virilizer homolog 0 5732700.0 1163300.0 2272900.0 2296500.0 False True 1525097.565413226 1933792.1796948093 2058880.2095835102 1.0 1.2679793237823753 1.34999901401433 20.540470108809785 -13.135407568071072 0.17651905655980887 2.6382019020682225e-07 1.420242553817391 0.9994868396475797 0.0033856753626148937 8.698772161287724 0.1266947588307627 3.0631858479904657 0.06296305685846401 7.321371291078432e-14 13.135407568071072 1.420242289997201 LAILHLINGTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAILHLINGTIK 12 0 Q69YN4-2;Q69YN4-3;Q69YN4;H0YBN5 Q69YN4-2 KIAA1429 Protein virilizer homolog 0 8603500.0 1163300.0 2250600.0 5189600.0 False True 1593403.4470004446 2151161.050261053 3963923.36316696 1.0 1.3500416698047049 2.487708540250104 20.603680170332677 -6.949638210978464 0.5628036027519083 0.9853334288712596 2.907049805959567 0.9991725698531074 0.01826851290714019 0.0836313947519989 0.03656642691748734 0.01951714865001599 0.09462959244638097 1.1229535412170721e-07 6.949638210978464 1.9217163770883072 up LAILQVGNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAILQVGNR 9 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 78876000.0 31271000.0 23402000.0 24203000.0 False True 40996583.82879481 19910512.820281558 21698705.731569696 1.0 0.4856627299345121 0.5292808254996397 25.289000361781476 -9.899107602249558 6.988284838649278 1.0000000099791027 0.5074717788643209 0.9941522959336427 0.017807012947763528 2.7770555825766015e-09 4.411715360432408e-10 0.01724156640501114 0.005747188716030745 1.2615149387179881e-10 9.899107602249558 -0.4925282311147817 LAILQVGNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAILQVGNR 9 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 50838600.0 17206000.0 7228600.0 26404000.0 False True 16659804.948088227 10115017.676651007 19488000.2969791 1.0 0.6071510265677955 1.1697616123180012 23.989868174034257 -6.718950569733447 1.7629229079269595 0.7607323792193222 1.1688439349757596 0.5076513725249386 0.16533358808966822 0.357353041493814 2.169903878427799 0.07447951457308832 0.1872145293928569 1.910070645459756e-07 6.718950569733447 0.4081115557564373 LAILQVGNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAILQVGNR 9 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 77856000.0 31271000.0 21556000.0 25029000.0 False True 42832733.76699984 20603584.643840443 19117665.688435696 1.0 0.48102427353619726 0.446333073028478 25.352210423304367 -13.999999999999998 0.38439356835002503 8.917633366691872 0.44351683287428917 0.9998145048210333 0.003448774916815884 24.600292230005863 0.20263831719042685 161.4708345093237 0.009280846339516237 1.0000000000000041e-14 13.999999999999998 -8.474116533817583 LAILQVGNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAILQVGNR 9 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 37493900.0 17206000.0 12487000.0 7800900.0 False True 14307551.355041284 12419730.05252456 9432032.122713666 1.0 0.8680542004938149 0.6592345460560083 23.770273449468533 -6.964351270519244 0.36902329493508074 1.0162372538743871 0.503794013637258 0.9998991313660186 0.0014089874389223605 0.0781818796132421 0.015640845904051136 0.0027565536895912614 0.017744264427789848 1.0855472449736201e-07 6.964351270519244 -0.5124432402371292 LAILQVGNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAILQVGNR 9 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 38299000.0 11892000.0 14794000.0 11613000.0 False True 15394428.426365277 13970700.895028835 9499553.159442447 1.0 0.9075167007241338 0.6170773539843176 23.875904967335977 -6.9504175621824995 0.5542389909837655 1.0039194104514757 0.5069306074170201 0.9992336549133167 0.004516247386800981 0.08331847495998206 0.03527157568548315 0.0048755572503611415 0.024114314761443115 1.1209401829092948e-07 6.9504175621824995 -0.4969888030344556 LAILQVGNRDDSNLYINVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAILQVGNRDDSNLYINVK 19 1 P11586;V9GYY3;A0A384N5Y3;F5H2F4 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 92456000.0 19663000.0 31621000.0 41172000.0 False True 29830208.557853185 25977985.493999336 33034336.15367135 1.0 0.8708616784766092 1.1074121754664916 24.830270728519885 -6.758478406009284 1.6183260173295968 0.9248470430562626 1.1082081642762722 0.6846771125446982 0.05430448757277272 0.28548050489728705 1.4732501496444925 0.026481092073759146 0.06373097032631066 1.743900065511183e-07 6.758478406009284 0.18336112122000958 LAILQVGNRDDSNLYINVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAILQVGNRDDSNLYINVK 19 1 P11586;V9GYY3;A0A384N5Y3;F5H2F4 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 70062000.0 19663000.0 24325000.0 26074000.0 False True 25454141.11567611 22971292.36660648 21328799.54183261 1.0 0.9024579639994001 0.8379304351658962 24.601397050612334 LAILYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAILYAK 7 0 P50502;Q8NFI4;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 0 34802100.0 9760200.0 8713900.0 16328000.0 False True 12795716.717911249 7413820.086516173 14638535.18923563 1.0 0.5793985792244385 1.1440183861482984 23.609157622563277 -6.70727400434543 1.8050206348385491 0.740702302956462 1.142581618281923 0.45207368422083827 0.17731715742292403 0.38059584058244333 2.4154916441481187 0.07822737833520868 0.19938666883559478 1.9621219475496647e-07 6.70727400434543 0.40187931532546106 LAILYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAILYAK 7 0 P50502;Q8NFI4;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 0 21760400.0 7323700.0 4333700.0 10103000.0 False True 7091213.152290707 6064169.009946945 7456721.216496734 1.0 0.8551666519836607 1.0515437988333427 22.757601031637172 -6.709151386681095 1.7987617554890298 0.910880218134684 1.0510605520106568 0.46085952054891044 0.06104020583681365 0.37676702987923993 2.375911515468518 0.027013476404073217 0.06868397744468754 1.9536583294508705e-07 6.709151386681095 0.14018033387597284 LAILYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAILYAK 7 0 P50502;Q8NFI4;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 0 34441700.0 6167800.0 23103000.0 5170900.0 False True 9357003.526579218 18980089.1454371 4148869.3485140223 1.0 2.0284366775670053 0.4433972197112966 23.15761516649763 -6.731537790216009 1.7173473116428377 1.6178312082589204 0.4440187779904009 0.5665292675560156 0.43228032818825957 0.33334714329710297 1.9266893919255534 0.19940532218262386 0.49400375122450596 1.8555053452622244e-07 6.731537790216009 -1.1738124302685193 LAILYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAILYAK 7 0 P50502;Q8NFI4;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 0 35657200.0 9760200.0 12442000.0 13455000.0 False True 13368809.699487431 11892271.29980806 10277206.114423342 1.0 0.8895534880913158 0.768745037549407 23.67236768408617 -6.9699759381947795 0.2587871917744434 1.0344232691687112 0.6202968463242216 0.9999821819634825 0.0003986071475363981 0.07631074101217064 0.009059385409066013 0.002541798370108939 0.011419305046283553 1.0715786737171447e-07 6.9699759381947795 -0.41412642284448964 LAILYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAILYAK 7 0 P50502;Q8NFI4;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 0 15920400.0 7323700.0 5187300.0 3409400.0 False True 6089981.044921306 5159354.985301572 4122289.7767154993 1.0 0.8471873635147317 0.6768969798605945 22.53800630707145 -6.96972664383314 0.26465451680549734 1.0451724249737253 0.4738288512060993 0.9999801621555863 0.0005877645332477122 0.07639167704610533 0.009348084030196968 0.0034508083921243864 0.015957588312257694 1.0721939594710341e-07 6.96972664383314 -0.571343573767626 LAILYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAILYAK 7 0 P50502;Q8NFI4;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 0 25881400.0 6167800.0 12179000.0 7534600.0 False True 7984338.685514284 11501227.943798566 6163380.111524585 1.0 1.4404734564510464 0.7719337009972531 22.92874148859008 -6.728996392450932 1.7268516019117532 1.265368039378486 0.7724002931838578 0.5546422501048793 0.18517932984326504 0.3381134161599829 1.9748043736751115 0.08499528996733832 0.21115316862817868 1.8663951943341616e-07 6.728996392450932 -0.49296774619462824 LAINLLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAINLLAK 8 0 A0A3B3ISQ4;Q9H6S3;Q9H6S3-3 A0A3B3ISQ4 EPS8L2 Epidermal growth factor receptor kinase substrate 8-like protein 2 0 29040900.0 8215800.0 14249000.0 6576100.0 False True 10770993.361920372 12123104.742166983 5895668.254405453 1.0 1.1255326537501034 0.5473653224268915 23.360647973724962 -6.849845747138415 1.2357675571871114 1.0669837764597594 0.5243134826571791 0.9400834310018545 0.06078061311196719 0.1576333341927435 0.4633037162322358 0.03848714146368263 0.089056445670236 1.413039339296129e-07 6.849845747138415 -0.5426702938025803 LAINLLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAINLLAK 8 0 A0A3B3ISQ4;Q9H6S3;Q9H6S3-3 A0A3B3ISQ4 EPS8L2 Epidermal growth factor receptor kinase substrate 8-like protein 2 0 20180900.0 9287300.0 2648000.0 8245600.0 False True 8992479.745110989 3705360.2091375794 6085829.997302329 1.0 0.41205099307030424 0.6767688301562269 23.10028757412566 -10.406495801847802 6.026544243583064 1.0001207243729366 0.544409911613279 0.7979514975869696 0.10807060444561992 0.00017534218289518485 1.7268000038696796e-05 0.10466634471453562 0.034879637602704516 3.921969375262892e-11 10.406495801847802 -0.45571081275965764 LAINLLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAINLLAK 8 0 A0A3B3ISQ4;Q9H6S3;Q9H6S3-3 A0A3B3ISQ4 EPS8L2 Epidermal growth factor receptor kinase substrate 8-like protein 2 0 30216800.0 8215800.0 11979000.0 10022000.0 False True 11253403.283646727 11449728.170744304 7655010.0095689995 1.0 1.0174458234677213 0.6802395521267013 23.423858035247854 -6.8947015319532365 0.9941344961038789 1.0161296566188942 0.6484153306842503 0.98374153118661 0.019765409401792028 0.11541206458740358 0.2002184653088124 0.015047378954266504 0.03820806654565105 1.274378594370842e-07 6.8947015319532365 -0.3677143259346439 LAINLLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAINLLAK 8 0 A0A3B3ISQ4;Q9H6S3;Q9H6S3-3 A0A3B3ISQ4 EPS8L2 Epidermal growth factor receptor kinase substrate 8-like protein 2 0 19465100.0 9287300.0 3929600.0 6248200.0 False True 7722801.447150692 3908430.4648354747 7554669.731587324 1.0 0.5060897255460944 0.9782291806005967 22.880692849559935 -10.71540729909873 9.95843915724746 1.0003777914432619 0.7421594530733455 0.28451309705811034 0.19275012538654046 0.0016189872456054458 4.6267577784885226e-05 0.18688894410797802 0.062209835466788585 1.9257180490284067e-11 10.71540729909873 -0.25821833836991637 LAINLLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAINLLAK 8 0 A0A3B3ISQ4;Q9H6S3;Q9H6S3-3 A0A3B3ISQ4 EPS8L2 Epidermal growth factor receptor kinase substrate 8-like protein 2 0 13339400.0 4249000.0 6566500.0 2523900.0 False True 5500414.260311648 6201068.50258259 2064576.0974009128 1.0 1.127382085986964 0.3753492009316287 22.39110884774162 -6.86330383813494 1.168855274883696 1.0698229775942605 0.336552738549026 0.957535463608328 0.06772016110022568 0.1434412841705494 0.37051619918847933 0.04512186400898814 0.10575663718253098 1.3699230146568632e-07 6.86330383813494 -0.7332702390452345 down LAIQLGAQALLGAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAIQLGAQALLGAAK 15 0 A0A087WTV6;Q96C36;A0A087WZR9;J3KR12 A0A087WTV6 PYCR2 Pyrroline-5-carboxylate reductase 2;Pyrroline-5-carboxylate reductase 0 17642100.0 12468000.0 2601700.0 2572400.0 False True 12072210.164638152 3640572.3776862607 1898611.2696541797 1.0 0.3015663518143682 0.1572712240560209 23.52518649122936 -13.999999999999998 0.2216656687768396 5.245689109448321 0.08130862579328334 0.9994996164526848 0.008231905365581615 13.045463873528174 0.1491375215440764 24.266062307205015 0.07898822981296875 1.0000000000000041e-14 13.999999999999998 -5.164380483655038 LAIQLGAQALLGAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAIQLGAQALLGAAK 15 0 A0A087WTV6;Q96C36;A0A087WZR9;J3KR12 A0A087WTV6 PYCR2 Pyrroline-5-carboxylate reductase 2;Pyrroline-5-carboxylate reductase 0 131076000.0 35420000.0 52424000.0 43232000.0 False True 53734729.548856296 43068527.609418504 34687176.25074124 1.0 0.8015026403037919 0.645526208877691 25.67935148897516 -6.973833879817486 0.13882164900607089 1.2124756783496446 0.23048858415982915 0.9999989619829275 0.00014767879888728807 0.07507723665094142 0.004199572816203911 0.008925876047952648 0.020422628148542312 1.0621017396451674e-07 6.973833879817486 -0.9819870941898154 LAIQLGAQALLGAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAIQLGAQALLGAAK 15 0 A0A087WTV6;Q96C36;A0A087WZR9;J3KR12 A0A087WTV6 PYCR2 Pyrroline-5-carboxylate reductase 2;Pyrroline-5-carboxylate reductase 0 18203600.0 12468000.0 2283800.0 3451800.0 False True 10367694.426052233 2271496.7161011943 4173555.4206800465 1.0 0.21909371773084993 0.4025538609811473 23.305591766663635 -10.724692085327181 10.184002886594154 1.0010829132810786 0.31082378942777594 0.9495344630119826 0.07489728985018933 0.0018432413605262666 4.9828944980597e-05 0.07258610823413619 0.024172996355487766 1.884985069744972e-11 10.724692085327181 -0.6902591238533027 LAIQLGAQALLGAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAIQLGAQALLGAAK 15 0 A0A087WTV6;Q96C36;A0A087WZR9;J3KR12 A0A087WTV6 PYCR2 Pyrroline-5-carboxylate reductase 2;Pyrroline-5-carboxylate reductase 0 96536000.0 35420000.0 34356000.0 26760000.0 False True 45851888.23258146 32444058.398648858 21889954.58078705 1.0 0.7075839109193924 0.47740573888149007 25.45047781106761 -7.287486197711546 0.16168703377645674 1.2509437591855728 1.2406136534813164e-13 0.9999921602485489 0.0005987481429330621 0.10582987941339868 0.009289376550357598 0.021907902492339443 0.04562961396974314 5.158385586479639e-08 7.287486197711546 -1.2509437591854486 down LAIVLFTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAIVLFTK 8 0 Q8NBN7;Q8NBN7-2;G8JLA1 Q8NBN7 RDH13 Retinol dehydrogenase 13 0 5741300.0 1607700.0 1714300.0 2419300.0 False True 2107710.2689889455 1458533.1222890615 2168974.0435642907 1.0 0.6919988689853042 1.0290665066621008 21.007245133538046 -6.666260338532258 1.9502909491811316 0.802783000889105 1.0276953637962336 0.2627789175743088 0.1309445077607562 0.4697315335446234 3.440760188085751 0.054117919158925124 0.14531620982527807 2.1564513333703936e-07 6.666260338532258 0.22491236290712857 LAIVLFTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAIVLFTK 8 0 Q8NBN7;Q8NBN7-2;G8JLA1 Q8NBN7 RDH13 Retinol dehydrogenase 13 0 6483800.0 3328100.0 1533700.0 1622000.0 False True 3222451.2872098368 2146114.4081398435 1197149.5410430254 1.0 0.6659881614527241 0.37150275810052 21.619727119305367 -7.3766421616115805 0.2287965462554354 1.1479547342956746 3.929111289370397e-11 0.9999441465601555 0.0019188315303828624 0.1163404421055939 0.017270490261114154 0.02119315470896475 0.05434158442656321 4.201049883335315e-08 7.3766421616115805 -1.1479547342563836 down LAIVLFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAIVLFTK 8 0 Q8NBN7;Q8NBN7-2;G8JLA1 Q8NBN7 RDH13 Retinol dehydrogenase 13 0 24690400.0 5425500.0 9523900.0 9741000.0 False True 8230880.157180104 7824285.634429669 7815687.080368033 1.0 0.9506013312080911 0.9495566611488222 22.972615280712812 LAIVLFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAIVLFTK 8 0 Q8NBN7;Q8NBN7-2;G8JLA1 Q8NBN7 RDH13 Retinol dehydrogenase 13 0 8321700.0 1607700.0 2466400.0 4247600.0 False True 2202110.1364588775 2357426.292705883 3244404.3620679798 1.0 1.0705306032044168 1.4733161200035039 21.070455195060937 -6.936889286078072 0.6878933353233236 0.995144553077082 1.5726666393535549 0.9977274332705773 0.009939350419064139 0.08921478737641272 0.06128943950322035 0.009460774019628002 0.03516825644610326 1.1564070054054448e-07 6.936889286078072 0.5775220862764728 LAIVLFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAIVLFTK 8 0 Q8NBN7;Q8NBN7-2;G8JLA1 Q8NBN7 RDH13 Retinol dehydrogenase 13 0 6035210.0 3328100.0 956710.0 1750400.0 False True 2767462.6098287175 951556.0133379337 2116400.547064824 1.0 0.34383698986879063 0.764744043712956 21.400132394739643 -10.258607709452145 5.803362571161273 1.000022206678495 0.5542905167911272 0.5992143694623276 0.17183458517607583 4.937384899660511e-05 6.307886833508636e-06 0.16638639509027595 0.055459373890781406 5.513054560604282e-11 10.258607709452145 -0.4457316898873678 LAIVLFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAIVLFTK 8 0 Q8NBN7;Q8NBN7-2;G8JLA1 Q8NBN7 RDH13 Retinol dehydrogenase 13 0 22523000.0 5425500.0 9219800.0 7877700.0 False True 7023416.702593739 8706710.025144434 6444039.432027876 1.0 1.239668724472671 0.9175077750474495 22.74374160280526 -6.707518123652042 1.804227568698722 1.1477159506027073 0.918324078508531 0.4532472600719357 0.10103514718721493 0.3800753748170655 2.410242463126161 0.044591739940802885 0.11361877639885984 1.9610193379782167e-07 6.707518123652042 -0.22939187209417622 LAK(ub)AAFDDAIAELDTLSEESYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAKAAFDDAIAELDTLSEESYK 22 1 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 1 20704900.0 14513000.0 0.0 6191900.0 True False 14052292.759014556 0.0 4570055.636981705 1.0 0.0 0.32521779295054976 23.744302202643553 -10.479108811096776 6.093330311169319 1.0005610044064324 0.1626088964753022 0.8983728400440993 0.13276960800049278 0.0010124774352956473 8.65516654680563e-05 0.1286317208831239 0.04285120672236623 3.318113128714693e-11 10.479108811096776 -0.8379521079311302 LAK(ub)AAFDDAIAELDTLSEESYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAKAAFDDAIAELDTLSEESYK 22 1 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 1 106886500.0 35127500.0 42482000.0 29277000.0 True False 53290985.66424188 34900755.18661906 23490388.11743507 1.0 0.6549091699393614 0.44079477653942256 25.667388181485933 -8.895222463600605 0.13345684174282094 1.5233713167433323 5.068709197622455e-06 0.9999066652936236 0.0022256180643803296 0.39115680634458116 0.04077649093507939 0.2563058704046358 0.17709582750515854 1.2728509071026114e-09 8.895222463600605 -1.5233662480341346 LAK(ub)AAFDDAIAELDTLSEESYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAKAAFDDAIAELDTLSEESYK 22 1 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 1 22884100.0 14513000.0 5007500.0 3363600.0 True False 12068202.534913061 4980523.603589075 4066913.208470773 1.0 0.4126980458921304 0.33699411297625115 23.52470747807783 -13.999999999999998 0.2888252358720164 6.02741901492778 0.3161192701391803 0.9996248338005701 0.005739413829954222 15.896199041750583 0.1704021400657023 47.45181616948104 0.028743863466489893 1.0000000000000041e-14 13.999999999999998 -5.7112997447886 LAK(ub)AAFDDAIAELDTLSEESYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAKAAFDDAIAELDTLSEESYK 22 1 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 1 88732500.0 35127500.0 34903000.0 18702000.0 True False 45473241.21654442 32960617.36779714 15298427.898724947 1.0 0.7248354523672079 0.3364270390552006 25.438514503578382 -6.966247713544789 0.3359530065958637 1.0441532446784956 0.004280125278373842 0.9999365997719567 0.002167478652329684 0.07754010163068957 0.01338102909623137 0.005553493860700098 0.03372016692431748 1.080817297242571e-07 6.966247713544789 -1.0398731194001218 down LAK(ub)EYHPDKNPNAGDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAKEYHPDKNPNAGDK 16 2 O60884;I3L320 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 26267500.0 4865600.0 8315900.0 13086000.0 True False 6378848.718537422 7075200.135124309 11731986.249775674 1.0 1.1091656891882757 1.839201205020214 22.604864633136394 -6.933585235516898 0.7167520912325892 0.9902387535203991 2.003742452050141 0.997197181789136 0.019723301128974358 0.09081836748112314 0.06887033481993002 0.018368749451769504 0.0648026902509278 1.1652383363519171e-07 6.933585235516898 1.0135036985297416 LAK(ub)EYHPDKNPNAGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAKEYHPDKNPNAGDK 16 2 O60884;I3L320 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 27397270.0 258840.0 589430.0 26549000.0 True False 250623.26588185277 824792.4728368439 19595020.44707233 1.0 3.290965305773576 78.18516121448074 17.935160823710877 -6.909899218192603 0.8983620166033726 4.0647524151059467e-13 87.77648519044054 0.9921171967542118 3.1836267250035744 0.09994668373044523 0.13384984313443019 2.6636190718418606 7.329426013295969 1.230554298496742e-07 6.909899218192603 87.77648519044013 up LAK(ub)EYHPDKNPNAGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAKEYHPDKNPNAGDK 16 2 O60884;I3L320 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 29223200.0 4865600.0 8702600.0 15655000.0 True False 6664543.807895946 8318090.3563502375 11957611.424845599 1.0 1.2481109879561778 1.7942130428610266 22.668074694659285 -6.958129497951314 0.46104394308144286 0.9842469554821573 2.080129906812214 0.9996943956013162 0.005799611676665513 0.08037626304020476 0.02365272573368367 0.007429928387834587 0.045108435684926444 1.1012109014573217e-07 6.958129497951314 1.0958829513300568 LAK(ub)LQAQVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAKLQAQVR 9 1 P20290;E9PPC3;Q96K17-3;P20290-2;D6RDG3;Q96K17;E9PL10 P20290;P20290-2;Q96K17 BTF3;BTF3L4 Transcription factor BTF3;Transcription factor BTF3 homolog 4 1 9799970.0 2672100.0 6355500.0 772370.0 True False 2587275.6481335894 8893284.29349467 570063.126396673 1.0 3.437316120495361 0.2203333559792539 21.303002336145596 -6.704122110595873 1.8163159170574703 2.5073596250370964 0.22918313573051952 0.4370491804781761 1.028071938347229 0.38703248651155686 2.4851092020049523 0.45109295150120904 1.1541625810161114 1.976413853622429e-07 6.704122110595873 -2.278176489306577 LAK(ub)VDATEESDLAQQYGVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAKVDATEESDLAQQYGVR 19 1 P07237;H7BZ94;I3NI03;I3L3U6 P07237 P4HB Protein disulfide-isomerase 1 77662000.0 0.0 38051000.0 39611000.0 True False 0.0 31260501.75618003 31781868.48788195 0.0 LAK(ub)VDATEESDLAQQYGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAKVDATEESDLAQQYGVR 19 1 P07237;H7BZ94;I3NI03;I3L3U6 P07237 P4HB Protein disulfide-isomerase 1 69671000.0 0.0 42509000.0 27162000.0 True False 0.0 40143336.781585835 22218794.705655348 0.0 LAK(ub)WYMQFDDDEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAKWYMQFDDDEK 13 1 M0R0N4;M0QYZ2;P53680;X6R390;P53680-2 M0R0N4 AP2S1 AP-2 complex subunit sigma 1 14539300.0 1197400.0 1821900.0 11520000.0 True False 1159389.1924236226 2549394.171082989 8502566.40740794 1.0 2.1989114507386924 7.333660226411042 20.14493351161943 -6.943307899625018 0.6280351006109565 0.9439829698793741 8.864393512516003 0.9985658712959525 0.10403181270585014 0.0862894162681307 0.04797702429351826 0.10401304505996992 0.43590910659037374 1.1394416767666835e-07 6.943307899625018 7.9204105426366285 LAK(ub)WYMQFDDDEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAKWYMQFDDDEK 13 1 M0R0N4;M0QYZ2;P53680;X6R390;P53680-2 M0R0N4 AP2S1 AP-2 complex subunit sigma 1 10171500.0 1197400.0 3427000.0 5547100.0 True False 995691.15381416 3408538.0707937633 6706972.96310745 1.0 3.423288494365741 6.735997339551806 19.925338787053708 -6.966753851692654 0.32655391376657805 0.5798409295708382 9.687335454465035 0.9999448671897879 0.017457085585385786 0.07737073645634732 0.012787889286330102 0.0489491601168887 0.28975864117291494 1.0795584182041411e-07 6.966753851692654 9.107494524894197 LAK(ub)YNQLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAKYNQLLR 9 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 50046700.0 2899600.0 2264100.0 44883000.0 True False 4398905.1891548205 1860053.6655059604 36011855.377082236 1.0 0.422844681920353 8.186549568257764 22.06871307609387 -6.8889933619002965 1.0282894209474964 0.5727261046767131 8.841351265356154 0.9802472064075116 0.49635832094205556 0.11996490407326833 0.22663409301718965 0.36826196863490246 0.9148440731128347 1.2912390097790615e-07 6.8889933619002965 8.268625160679441 up LAK(ub)YNQLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAKYNQLLR 9 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 30911500.0 2899600.0 2060900.0 25951000.0 True False 3753589.3596610166 1946209.1033233015 21228184.279746074 1.0 0.5184928123035446 5.655435969603018 21.83983939818632 -6.883945682761203 1.0575187374973354 0.6826144767231155 6.048240988723919 0.9767324483933282 0.3533431792037006 0.1241937024129919 0.25163661121179387 0.25639490860244585 0.6267524611039758 1.3063342612251968e-07 6.883945682761203 5.365626512000803 up LALASLGYEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LALASLGYEK 10 0 Q8WUM4;Q8WUM4-2;A0A3B3IT07;Q8WUM4-3 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 16039400.0 6398700.0 6577800.0 3062900.0 False True 8388757.665098954 5596417.880063585 2745980.489411426 1.0 0.6671330968764574 0.3273405430265262 23.000025739570845 -7.288062533782064 0.2794409264588424 1.091372923061471 4.8903476465864525e-14 0.9999078962938021 0.002635510866285423 0.10325778339824829 0.018354182659167075 0.013739405235558446 0.047206558712358224 5.151544624827049e-08 7.288062533782064 -1.0913729230614222 down LALASLGYEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LALASLGYEK 10 0 Q8WUM4;Q8WUM4-2;A0A3B3IT07;Q8WUM4-3 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 17435800.0 6398700.0 6805800.0 4231300.0 False True 8764472.308365641 6505097.252229034 3231954.0863589426 1.0 0.7422120834382641 0.36875626650951476 23.063235801093736 -6.965829379544747 0.3435247419629937 1.0388879230100465 0.059602920541483036 0.9999292305606322 0.002180015774259822 0.07768068503917365 0.013874086960529382 0.0052169982314288505 0.032242277993251835 1.0818588956859405e-07 6.965829379544747 -0.9792850024685634 down LALASLGYEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LALASLGYEK 10 0 Q8WUM4;Q8WUM4-2;A0A3B3IT07;Q8WUM4-3 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 17173200.0 8150800.0 7044700.0 1977700.0 False True 6777751.341663991 7006748.80283654 2391227.926148371 1.0 1.0337866424465683 0.35280549633756636 22.692375278331276 -6.89522951313947 0.990948028559495 1.0321362202098854 0.2878671448582781 0.9840393212111483 0.03958822975862683 0.11500197839901281 0.1978897733606649 0.030211350533361086 0.07688153532272772 1.272830246146769e-07 6.89522951313947 -0.7442690753516072 down LALDMEIHAYR ddPTM_RPMI8226_Bortezomib_8h_R1 2 LALDMEIHAYR 11 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 237632800.0 63278000.0 99217000.0 75137800.0 False True 95997352.24146049 81510951.1640407 60286780.895932384 1.0 0.8490958267163203 0.6280046218805502 26.516491278787065 -6.965645494544563 0.3467972524308459 1.0221687119491365 0.44750786885924365 0.9999258365502856 0.0013155709549843827 0.07774262438895116 0.014091522472137422 0.0030604449315785208 0.01904446306069984 1.0823170634813963e-07 6.965645494544563 -0.5746608430898928 LALDMEIHAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LALDMEIHAYR 11 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 22123800.0 11385000.0 4563300.0 6175500.0 False True 9467131.941017376 4538716.597155874 7466768.497714141 1.0 0.4794183312784933 0.7887043873724371 23.174495998062252 -10.290519767008345 5.922355555507103 1.0000229939758618 0.634061359325468 0.6511459609916324 0.12626550366466707 3.833740881609251e-05 4.592685373358576e-06 0.12226371780128986 0.040752016074478356 5.122479546562263e-11 10.290519767008345 -0.3659616346503938 LALDMEIHAYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LALDMEIHAYR 11 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 214961700.0 58332200.0 85284000.0 71345500.0 False True 75512182.79956482 80537870.42933881 58361351.0666496 1.0 1.0665546597045656 0.7728733153107307 26.17020608542565 -6.84714692253926 1.2487247187574761 1.0354486152481142 0.761760272503678 0.9360549280707682 0.03179296161090362 0.1606262153123825 0.4834124150207654 0.019936091524072212 0.046058534736883955 1.4218476923312775e-07 6.84714692253926 -0.2736883427444362 LALDMEISAYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LALDMEISAYR 11 0 P20700;E9PBF6 P20700 LMNB1 Lamin-B1 0 60796000.0 16729000.0 24345000.0 19722000.0 False True 25379116.053721543 20000444.541646816 15823938.055540329 1.0 0.7880670272089318 0.6235023324707142 24.597138485671067 -6.973953784159887 0.1333583185311289 1.2426444266852037 0.1646548699507697 0.9999991281893472 0.00014377739355766217 0.07503939803660482 0.004015026119672228 0.009981875606835949 0.02211113160382326 1.0618085445034685e-07 6.973953784159887 -1.077989556734434 LALDMEISAYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LALDMEISAYR 11 0 P20700;E9PBF6 P20700 LMNB1 Lamin-B1 0 46491000.0 16729000.0 14861000.0 14901000.0 False True 21656020.277889762 14033972.286131116 12189170.897171428 1.0 0.6480402265073347 0.5628536887553738 24.368264807763516 -13.999999999999998 0.19926844614185565 2.9510786357351457 0.5071291836373955 0.9994869127810746 0.004286042577533818 12.516552908673452 0.14154780019906774 9.515227511010709 0.05453981793967118 1.0000000000000041e-14 13.999999999999998 -2.4439494520977503 LALDMEISAYRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LALDMEISAYRK 12 1 P20700;E9PBF6 P20700 LMNB1 Lamin-B1 0 11454400.0 2514800.0 4880200.0 4059400.0 False True 3255458.1741190217 4608612.5799594205 3320630.852961391 1.0 1.4156571313365387 1.0200195104211425 21.63442917231943 -10.767765722502258 8.675339955002974 0.9978941716232389 1.2178383208788404 0.28785820321137334 0.16151838238190042 0.006630487117465996 0.00017749444326061806 0.15762299860154 0.05212983375595517 1.7070029729756507e-11 10.767765722502258 0.21994414925560146 LALEK(ub)VPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LALEKVPK 8 1 E9PAM4;Q9BTU6 E9PAM4 PI4K2A Phosphatidylinositol 4-kinase type 2-alpha 1 5127900.0 1306300.0 2122000.0 1699600.0 True False 1712571.950227193 1805405.8714912138 1523741.6957144095 1.0 1.0542073115536577 0.8897387905438174 20.707733170568382 -6.817886249573017 1.380912741841788 1.029281468155908 0.8863060444337234 0.8794728422181495 0.02375738625660513 0.19624074017005555 0.7358646372042871 0.013521142613760712 0.03118423007945601 1.520945843759428e-07 6.817886249573017 -0.14297542372218452 LALEK(ub)VPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LALEKVPK 8 1 E9PAM4;Q9BTU6 E9PAM4 PI4K2A Phosphatidylinositol 4-kinase type 2-alpha 1 5714100.0 1306700.0 2298800.0 2108600.0 True False 1265219.523751417 3216722.828083634 1556294.403355936 1.0 2.542422692424115 1.2300587954424482 20.2709562928609 -6.606777410355398 2.1658301272689893 2.032743436257993 1.2346443837670995 0.040388330246790005 0.6655414520215954 0.6216442435684869 5.521047003938457 0.25419085241526507 0.7392023652235888 2.4729913064431903e-07 6.606777410355398 -0.7980990524908933 LALEK(ub)VPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LALEKVPK 8 1 E9PAM4;Q9BTU6 E9PAM4 PI4K2A Phosphatidylinositol 4-kinase type 2-alpha 1 2996120.0 1306300.0 992330.0 697490.0 True False 1789274.411430136 948485.5794035153 532757.2272574616 1.0 0.5300950895762306 0.29775043104296006 20.770943232091273 -10.135469762976435 0.1616453063477834 1.724217913462066 1.4207985073455825e-19 0.9996590031985882 0.005394110929214284 1.7337317962664 0.07702205464396418 0.7104634555779543 0.18407668052380272 7.320322879436476e-11 10.135469762976435 -1.724217913462066 LALEK(ub)VPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LALEKVPK 8 1 E9PAM4;Q9BTU6 E9PAM4 PI4K2A Phosphatidylinositol 4-kinase type 2-alpha 1 5465220.0 1306700.0 3478800.0 679720.0 True False 1086578.946625156 3460059.013912267 821846.3093298123 1.0 3.1843604412352975 0.756361341145449 20.051361568295178 -6.669644429299671 1.9386890571464133 2.394686447718671 0.7661987549022252 0.2774824952251911 0.9279428295448072 0.4619133908797083 3.346733151051904 0.385387983881579 1.0301168726913543 2.139713223796293e-07 6.669644429299671 -1.6284876928164458 LALEVAEK(ub)AGTFGPGS ddPTM_RPMI8226_Bortezomib_2h_R1 1 LALEVAEKAGTFGPGS 16 1 Q9Y296;E9PKS9;E9PQE8;J3KP27;Q9Y296-2 Q9Y296 TRAPPC4 Trafficking protein particle complex subunit 4 1 9120700.0 1599400.0 1662200.0 5859100.0 True False 1548627.9224672967 2325925.128258487 4324425.940767694 1.0 1.501926379160715 2.7924241052543826 20.56255912927352 -6.954857994689754 0.502691766070988 0.9747474907504714 3.375518631943569 0.9995294272591715 0.01637777721957229 0.08159170323831005 0.02832833669232933 0.019111059972483944 0.10646531847139014 1.1095375517791535e-07 6.954857994689754 2.400771141193098 LALEVAEK(ub)AGTFGPGS ddPTM_RPMI8226_Bortezomib_8h_R1 1 LALEVAEKAGTFGPGS 16 1 Q9Y296;E9PKS9;E9PQE8;J3KP27;Q9Y296-2 Q9Y296 TRAPPC4 Trafficking protein particle complex subunit 4 1 79333400.0 5306300.0 8223100.0 65804000.0 True False 8050045.042492824 6755623.557626455 52797810.557082176 1.0 0.839203199729485 6.5586975325460415 22.94056542489916 -6.9004329743295365 0.9585440273751029 0.7650213468223647 7.164324634959147 0.9867800013835304 0.30573933016821353 0.11108668581937793 0.1756353316806209 0.23903155981530824 0.6232691875701701 1.2576709386512868e-07 6.9004329743295365 6.399303288136783 up LALEVAEK(ub)AGTFGPGS ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LALEVAEKAGTFGPGS 16 1 Q9Y296;E9PKS9;E9PQE8;J3KP27;Q9Y296-2 Q9Y296 TRAPPC4 Trafficking protein particle complex subunit 4 1 12255800.0 1599400.0 3088800.0 7567600.0 True False 1329971.9654337456 3072160.021321207 9149950.171370981 1.0 2.309943443296024 6.879806799827465 20.342964404707796 -6.948018965431019 0.5801848497347545 0.9454123269015424 8.470442487758291 0.9990365117321063 0.07823347656711296 0.08429111720164474 0.03933069673570931 0.08195185932704284 0.38176620857290505 1.1271482330798493e-07 6.948018965431019 7.5250301608567485 LALEVAEK(ub)AGTFGPGS ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LALEVAEKAGTFGPGS 16 1 Q9Y296;E9PKS9;E9PQE8;J3KP27;Q9Y296-2 Q9Y296 TRAPPC4 Trafficking protein particle complex subunit 4 1 94089100.0 5306300.0 7903800.0 80879000.0 True False 6869109.952810466 7463946.582001416 66159851.888620175 1.0 1.0865958811661727 9.631502821053427 22.711691746991608 -6.909115001338899 0.901722461658716 0.7279695682731476 10.715203059868857 0.9905837050182338 0.3928734895244928 0.1050066658097797 0.14195641845500478 0.3202497558993616 0.8787264796520482 1.2327783498428882e-07 6.909115001338899 9.98723349159571 up LALGGCTNRPFYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LALGGCTNRPFYR 13 1 Q9Y3D3;A6ND22;Q9Y3D3-2 Q9Y3D3 MRPS16 28S ribosomal protein S16, mitochondrial 0 24645900.0 5756300.0 5856600.0 13033000.0 False True 7546565.044088489 4982818.108848002 11684470.18136378 1.0 0.6602763084578768 1.5483163681888183 22.84738869435761 -6.803016077361871 1.443581752873362 0.8132709336799891 1.5615055329454537 0.8408325514668846 0.1459625336218762 0.21647971163616428 0.8902990823753415 0.07953284204719802 0.1846336034725851 1.5739245974958737e-07 6.803016077361871 0.7482345992654645 LALGGCTNRPFYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LALGGCTNRPFYR 13 1 Q9Y3D3;A6ND22;Q9Y3D3-2 Q9Y3D3 MRPS16 28S ribosomal protein S16, mitochondrial 0 11872200.0 4825800.0 2225100.0 4821300.0 False True 4672607.620509367 3113594.0337432115 3558456.894100338 1.0 0.6663504164305999 0.7615569684219335 22.155796462141502 -10.203107099746621 7.684684758992902 1.0000002150629612 0.713953692426267 0.9232886294595253 0.03886791209142086 1.432318456039321e-07 1.4813838457148341e-08 0.037633722657520484 0.012544564685993905 6.264593568102392e-11 10.203107099746621 -0.28604652263669417 LALGGCTNRPFYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LALGGCTNRPFYR 13 1 Q9Y3D3;A6ND22;Q9Y3D3-2 Q9Y3D3 MRPS16 28S ribosomal protein S16, mitochondrial 0 19088300.0 5756300.0 6306800.0 7025200.0 False True 7884559.668158382 6028144.722201372 5365992.448535638 1.0 0.7645505869586984 0.6805697051423275 22.9105987558805 -13.999999999999998 0.14356959504424657 2.128751027992559 0.5809765216092558 0.999589092712263 0.0027407256136858186 11.939337567721045 0.11896249429200603 3.7686211615461853 0.08926569856048963 1.0000000000000041e-14 13.999999999999998 -1.5477745063833033 LALGGCTNRPFYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LALGGCTNRPFYR 13 1 Q9Y3D3;A6ND22;Q9Y3D3-2 Q9Y3D3 MRPS16 28S ribosomal protein S16, mitochondrial 0 10127900.0 4825800.0 1749200.0 3552900.0 False True 4012866.5191885526 1739776.712410983 4295794.963246466 1.0 0.43354960951025745 1.070505321496496 21.93620173757578 -6.672108348766906 1.929963951402613 0.639094964855616 1.067952781371369 0.2884157321085643 0.24049929631013314 0.45627968761423826 3.278543164251551 0.10025078726351332 0.2671044606173832 2.127608179277122e-07 6.672108348766906 0.42885781651575294 LALGIPLPELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LALGIPLPELR 11 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 12362000.0 1945900.0 5153400.0 5262700.0 False True 2551093.744122407 4384532.807795867 4718166.287383043 1.0 1.7186874523516091 1.8494680167098774 21.282684483433354 -11.175226297213344 0.3096295078504878 1.9093720774938203e-09 1.8837810044539953 0.9993160272019987 0.00976689398554824 3.205763834271814 0.16012165962297006 2.2725400547329215 0.0452475383451579 6.679957552619293e-12 11.175226297213344 1.8837810025446233 LALGIPLPELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LALGIPLPELR 11 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 6520200.0 1825700.0 1625300.0 3069200.0 False True 1767744.1528376534 2274290.7658275324 2265284.445973651 1.0 1.2865497318583972 1.2814549222732974 20.753478056642987 -10.00207064841818 4.730144138836538 0.9999945928026184 1.2840023270772896 0.9997586918824014 0.002079947342635875 1.186073282423126e-07 2.5022872221774346e-08 0.0020139386836067028 0.0006713001126833873 9.952435039460035e-11 10.00207064841818 0.2840077342746712 LALGIPLPELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LALGIPLPELR 11 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 17939700.0 1945900.0 8002700.0 7991100.0 False True 2665351.815970227 7649114.252610021 6103766.761870565 1.0 2.8698328703843665 2.290041684290261 21.345894544956245 -10.20238209407023 5.114011185190588 0.9998683004323317 2.5799372773382836 0.9082645581232759 0.2366987605524546 0.00035547385451427615 5.5442373294931955e-05 0.22920113037188083 0.07639419647346071 6.275060334924379e-11 10.20238209407023 1.580068976905952 LALGIPLPELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LALGIPLPELR 11 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 4792900.0 1825700.0 1082500.0 1884700.0 False True 1518150.4422235766 1076668.3576405726 2278782.0561317815 1.0 0.709197407381852 1.5010251900952167 20.533883332077263 -6.807283093717742 1.4257479529720354 0.8409957435449035 1.5140565300247408 0.8526564109182426 0.12553464597391917 0.21052976132819629 0.8439307452864461 0.06924021806104942 0.160385968283797 1.558536243881605e-07 6.807283093717742 0.6730607864798374 LALGQINIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LALGQINIAK 10 0 Q9BZE4;Q9BZE4-2;Q5T3R7 Q9BZE4 GTPBP4 Nucleolar GTP-binding protein 1 0 10671100.0 2760800.0 3657700.0 4252600.0 False True 3619435.5356252324 3111985.4176029284 3812581.745819661 1.0 0.8597985478598542 1.053363627641199 21.787333290541113 -6.7124339923815945 1.7867565864305577 0.9140217032551273 1.0529379199752753 0.47657284427798574 0.05905811173080055 0.3701928180478082 2.3053153203430594 0.02629012890779073 0.06658720767860236 1.9389473105886266e-07 6.7124339923815945 0.13891621672014798 LALGQINIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LALGQINIAK 10 0 Q9BZE4;Q9BZE4-2;Q5T3R7 Q9BZE4 GTPBP4 Nucleolar GTP-binding protein 1 0 8452900.0 3386600.0 1458500.0 3607800.0 False True 3279094.2367311167 2040886.6559770212 2662808.948319997 1.0 0.6223934137408483 0.8120562436090627 21.644865932754158 -10.140618923344283 5.190107157852119 1.0000097985391374 0.7172248286746987 0.7477202845955437 0.07742952605913309 108228800.64642614 9.005979515910255 12673.471096445523 0.026506186274562738 7.234042845508155e-11 10.140618923344283 -0.2827849698644387 LALGQINIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LALGQINIAK 10 0 Q9BZE4;Q9BZE4-2;Q5T3R7 Q9BZE4 GTPBP4 Nucleolar GTP-binding protein 1 0 7667200.0 2760800.0 1631900.0 3274500.0 False True 3781542.367814688 1559797.2620283528 2501130.5404443904 1.0 0.4124764739657651 0.661404870597752 21.850543352064005 -10.338172639905629 5.823185111231519 1.000064817668808 0.5369406722817677 0.8218690107105923 0.10162459237292366 8.552947362614233e-05 9.720671658348561e-06 0.09841128814759811 0.03279919615212021 4.5901550960417794e-11 10.338172639905629 -0.4631241453870404 LALHNFG ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LALHNFG 7 0 P61970 P61970 NUTF2 Nuclear transport factor 2 0 9361100.0 1107000.0 4488900.0 3765200.0 False True 1516287.815550153 4290565.555192768 2875937.306728119 1.0 2.8296511461684646 1.8966961794681745 20.532112195297405 -10.331640098397083 7.142243557860867 0.999977042164684 2.363173662818317 0.7400271897430843 0.3808772702351637 0.00013924912368547634 1.303111443640226e-05 0.3687889878944245 0.12292761038081086 4.6597208652654735e-11 10.331640098397083 1.3631966206536328 LALHVEK(ub)SGASSFGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LALHVEKSGASSFGEK 16 1 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;Q9Y2X0-4;Q9Y2X0-5;U3KQ43;B9TWZ6;B9TX12;B9TX11 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 10511000.0 3140100.0 882200.0 6488700.0 True False 3040419.2443038425 1234467.0606122233 4789114.813172563 1.0 0.4060186972322879 1.5751494870797382 21.535838840353318 -6.768567925509326 1.5797708437506335 0.6586928104215422 1.581402292537257 0.725138710224847 0.25024363611958356 0.2687368128440201 1.323365987945218 0.12487134592886762 0.2976577652767898 1.7038528086278203e-07 6.768567925509326 0.9227094821157149 LALHVEK(ub)SGASSFGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LALHVEKSGASSFGEK 16 1 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;Q9Y2X0-4;Q9Y2X0-5;U3KQ43;B9TWZ6;B9TX12;B9TX11 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 11846700.0 3140100.0 4345700.0 4360900.0 True False 2611132.2800165755 4322288.851546093 5272744.0274765715 1.0 1.655331246381227 2.019332405267151 21.316244115787594 -9.568503745085865 0.1457944532170629 4.351041426562272e-12 2.6202310291634316 0.9997948530726717 0.0060409600948323925 1.0353525989801668 0.059595996563946714 0.7367682036100555 0.3157257314603583 2.700823817997159e-10 9.568503745085865 2.6202310291590805 LALIQLQISSIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LALIQLQISSIK 12 0 Q9NQR4;H7C579;F8WF70 Q9NQR4 NIT2 Omega-amidase NIT2 0 40649000.0 18984000.0 10044000.0 11621000.0 False True 18381363.311316244 14054621.578768048 8577111.477472875 1.0 0.7646125774640179 0.4666199852647757 24.13174043679794 -6.967922750517019 0.30373606740822046 1.0494400626072447 0.17240527124627053 0.9999613425029876 0.0013569659827538786 0.0769826815787526 0.011430164065384626 0.004854476026396996 0.026621752888959092 1.0766567053037164e-07 6.967922750517019 -0.8770347913609742 down LALIQLQISSIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LALIQLQISSIK 12 0 Q9NQR4;H7C579;F8WF70 Q9NQR4 NIT2 Omega-amidase NIT2 0 417470000.0 119540000.0 148270000.0 149660000.0 False True 181350919.54461545 121810060.06120235 120079635.4016919 1.0 0.6716815132069677 0.6621396555541051 27.434208819648852 LALIQLQISSIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LALIQLQISSIK 12 0 Q9NQR4;H7C579;F8WF70 Q9NQR4 NIT2 Omega-amidase NIT2 0 15755500.0 3340600.0 2952000.0 9462900.0 False True 4575710.096320539 2821570.879041423 7227957.914543048 1.0 0.6166410938731303 1.5796363323706322 22.125564219375413 -6.798701679986659 1.461360100031166 0.7881311898188992 1.5924829965915361 0.8282827704312925 0.1640369806516322 0.2226261987486986 0.9387784859156697 0.08831445757321627 0.20553754615866504 1.5896383076787882e-07 6.798701679986659 0.804351806772637 LALIQLQISSIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LALIQLQISSIK 12 0 Q9NQR4;H7C579;F8WF70 Q9NQR4 NIT2 Omega-amidase NIT2 0 41367200.0 18984000.0 9405200.0 12978000.0 False True 15786037.133796584 9354532.320813963 15691639.796507837 1.0 0.592582688202772 0.9940202004791532 23.912145712232217 -10.881448509207925 10.375522772201373 1.0121703690949815 0.7933014443409642 0.2611695322069988 0.1638861781148986 0.04505360459154535 0.0005147849022096034 0.15495277928722206 0.05289403654271541 1.3138672603644507e-11 10.881448509207925 -0.2188689247540173 LALIQLQISSIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LALIQLQISSIK 12 0 Q9NQR4;H7C579;F8WF70 Q9NQR4 NIT2 Omega-amidase NIT2 0 355820000.0 119540000.0 123290000.0 112990000.0 False True 154746886.48567998 116428803.11937982 92426979.3753037 1.0 0.7523822014354644 0.5972784427159169 27.2053351417413 -9.687491701352666 0.08054281130187349 1.7837700825716716 7.381803934145808e-08 0.999974007249971 0.0008455354453970944 1.1986805317281395 0.034110875873838147 0.47428510434517773 0.28176055892707974 2.0535642662898263e-10 9.687491701352666 -1.7837700087536323 LALK(ub)WHPDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LALKWHPDK 9 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q5F1R6-3;Q5F1R6;Q5F1R6-2;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJC21 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily C member 21 1 10024100.0 2453100.0 2913100.0 4657900.0 True False 3216037.8558541886 2478476.8351748637 4175945.1897317814 1.0 0.7706615861698473 1.2984751352134314 21.616852957847133 -6.788664236193799 1.502172262341816 0.8715980559198998 1.3038442044675187 0.7968014924598799 0.09740999835556033 0.23735586729645022 1.05819612239505 0.05105076097331064 0.11961369458140725 1.626805993639612e-07 6.788664236193799 0.4322461485476189 LALK(ub)WHPDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LALKWHPDK 9 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q5F1R6-3;Q5F1R6;Q5F1R6-2;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJC21 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily C member 21 1 8490000.0 1947600.0 2128900.0 4413500.0 True False 1885774.504062342 2978980.8720668405 3257471.947838103 1.0 1.579712137187935 1.7273920825744784 20.846725741985757 -11.399700851684411 0.24502095061087817 3.815354035595155e-09 1.7994398716360478 0.9992962295605994 0.00832817389532254 3.7589137400616797 0.13662042094479615 2.0827408668901253 0.06969550686986221 3.983814869917643e-12 11.399700851684411 1.7994398678206938 LALK(ub)WHPDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LALKWHPDK 9 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q5F1R6-3;Q5F1R6;Q5F1R6-2;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJC21 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily C member 21 1 10296500.0 2453100.0 2736000.0 5107400.0 True False 3360077.362534844 2615114.4732579067 3901137.3102048147 1.0 0.7782899591588758 1.1610260387760223 21.680063019370024 -6.749616288184806 1.651024448330481 0.869576840427841 1.161776901299715 0.6474587805559888 0.093162423192205 0.3006933150072856 1.6125111091414606 0.044575232202747714 0.10827044972932727 1.7798512659436757e-07 6.749616288184806 0.292200060871874 LALK(ub)WHPDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LALKWHPDK 9 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q5F1R6-3;Q5F1R6;Q5F1R6-2;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJC21 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily C member 21 1 8399400.0 1947600.0 2974400.0 3477400.0 True False 1619515.6933092193 2958376.3168278234 4204508.262319024 1.0 1.8267043221932961 2.5961516024137987 20.627131017420034 -6.971988743069125 0.20519912245844338 0.571635607394772 3.872585808134368 0.9999940209132764 0.0015936986728765088 0.07566250245344257 0.006668573736129427 0.023944563373296878 0.08064326845508676 1.0666237678039899e-07 6.971988743069125 3.300950200739596 LALK(ub)WHPDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LALKWHPDK 9 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q5F1R6-3;Q5F1R6;Q5F1R6-2;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJC21 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily C member 21 1 8684900.0 3116700.0 2915200.0 2653000.0 True False 4034629.5893417997 2752966.557333246 2170181.222078775 1.0 0.682334399322729 0.5378885902715083 21.94400479818051 -13.999999999998066 0.10613453075127624 2.5444409914081167 0.25752877731094 0.9997627132007325 0.0029733523329055706 12.03680955174486 0.09820489139211509 4.014247483709652 0.24931891725150887 1.0000000000044542e-14 13.999999999998066 -2.286912214097177 LALK(ub)WHPDKNPENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LALKWHPDKNPENK 14 2 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 19041800.0 5780400.0 4523300.0 8738100.0 True False 7578160.37747322 3848441.2716853064 7833965.23377386 1.0 0.507833178501362 1.0337555347945715 22.85341624141373 -11.820066495902601 17.64247620863761 0.9058604227532288 0.7937149209831724 0.0 0.24623931502257992 0.0 0.0 0.0 0.07148296811081602 1.5133295210694238e-12 11.820066495902601 -0.11214550177005633 LALK(ub)WHPDKNPENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LALKWHPDKNPENK 14 2 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 25950900.0 3648800.0 6388100.0 15914000.0 True False 3532970.84125214 8938901.643501412 11745645.990233488 1.0 2.530137395737273 3.3245805068888283 21.752450411574383 -9.00430649092102 0.23351450133008053 5.323941217544424e-22 3.952079760764228 0.9993088458370907 0.025362264540835962 0.47370597945988563 0.07875336246885394 0.738473756670089 0.36033356100470715 9.90132940240101e-10 9.00430649092102 3.952079760764228 LALK(ub)WHPDKNPENK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LALKWHPDKNPENK 14 2 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 26517000.0 6317500.0 11325000.0 8874500.0 True False 9584109.371115163 9303965.267371133 7120451.185168479 1.0 0.970769938770906 0.7429434399641013 23.19221294116802 -6.930583933998458 0.7419817285305911 1.003390576485547 0.6954684096284478 0.9966517851530937 0.006649083463562516 0.09233579346511278 0.07620269131485602 0.006078806066504652 0.02054858302126241 1.1733188988965751e-07 6.930583933998458 -0.3079221668570993 LALK(ub)WHPDKNPENK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LALKWHPDKNPENK 14 2 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 17536300.0 5780400.0 3880100.0 7875800.0 True False 7917570.089436392 3708664.3522251463 6015698.2471925225 1.0 0.4684094122732478 0.7597909685976327 22.91662630293662 -10.115698445705249 5.380602095819712 1.0000067359641616 0.6141001904352592 0.7004770212023289 0.11895602224278111 9.612286841463158e-06 1.5796363098710971e-06 0.11518068396763011 0.03839289108968671 7.661283869026579e-11 10.115698445705249 -0.38590654552890236 LALK(ub)WHPDKNPENK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LALKWHPDKNPENK 14 2 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 21474500.0 3648800.0 8542500.0 9283200.0 True False 3034138.8692476247 8496479.856946513 11224274.199332831 1.0 2.800293665877391 3.6993277773459705 21.53285568700866 -8.996263738775186 0.25541340742484475 1.0021447718066801e-16 4.290990606872431 0.9991067045084899 0.033542875597026796 0.46566226630953056 0.08662413573637336 0.7877465166825208 0.36744871410293034 1.008640172066455e-09 8.996263738775186 4.290990606872431 LALK(ub)WHPDKNPENK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LALKWHPDKNPENK 14 2 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 24896000.0 6317500.0 8001500.0 10577000.0 True False 8178128.28654243 7556209.491116204 8652094.529184764 1.0 0.9239534067410476 1.0579553445526493 22.96333926326047 -6.752753340648358 1.6396730995050675 0.9554326660384899 1.058278494048244 0.6607445584318772 0.031960545399383276 0.29525746333250974 1.562624903495599 0.015392649865588682 0.0372615347320485 1.7670411340796922e-07 6.752753340648358 0.10284582800975406 LALK(ub)WHPDKNPENKEEAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LALKWHPDKNPENKEEAER 19 3 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 12331700.0 3491600.0 4133700.0 4706400.0 True False 4577521.412702495 3516968.073036395 4219426.874976639 1.0 0.7683127518042637 0.921771084077913 22.12613520399287 -10.079642234012265 4.5311236610287295 1.0000104697344416 0.8450419179340763 0.5761853511192019 0.06264910183203373 14632558.697927857 32550635.45765409 876.2188668404729 0.021446459266425584 8.324492492818531e-11 10.079642234012265 -0.15496855180036528 LALK(ub)WHPDKNPENKEEAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LALKWHPDKNPENKEEAER 19 3 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 32383500.0 4960800.0 7746700.0 19676000.0 True False 4803322.119404627 10839997.708506815 14522265.332652632 1.0 2.256770926254356 3.0233794385733743 22.19560113086323 -8.610707085296099 0.19492183194094032 9.494912602378748e-19 3.939162185124392 0.9996969382316109 0.014520246254876771 0.21464626318855168 0.05365227406532614 0.5168286158200072 0.3944460130741696 2.4507155967249933e-09 8.610707085296099 3.939162185124392 LALK(ub)WHPDKNPENKEEAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LALKWHPDKNPENKEEAER 19 3 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 63590000.0 11389000.0 21194000.0 31007000.0 True False 17277945.647428676 17411765.11052218 24878452.859149143 1.0 1.0077451026773787 1.4398964649394868 24.042428355066015 -6.910786984164515 0.8903621826770135 0.9869496123994963 1.496694242930959 0.9912147121767594 0.019267856807355918 0.10390096073914462 0.13596430560107126 0.015836328861293283 0.04395729000632078 1.228041421923133e-07 6.910786984164515 0.5097446305314628 LALK(ub)WHPDKNPENKEEAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LALKWHPDKNPENKEEAER 19 3 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 17993200.0 3491600.0 4819700.0 9681900.0 True False 4782538.8769421 4606749.717383454 7395234.624989622 1.0 0.9632435482320545 1.5462989042585786 22.18934526551576 -6.891876783990068 1.011246010538139 0.9700663642609223 1.5983244705805875 0.9820713943588456 0.035699008346194425 0.11763262093734352 0.2130743417337867 0.02683059444859321 0.06735517222042915 1.282694451138225e-07 6.891876783990068 0.6282581063196652 LALK(ub)WHPDKNPENKEEAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LALKWHPDKNPENKEEAER 19 3 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 24696700.0 4960800.0 10800000.0 8935900.0 True False 4125125.000702589 10741818.256367832 10804355.375066603 1.0 2.6039982435776596 2.619158297803439 21.976006406297508 -10.746107782930538 0.820751105266752 5.405730939457651e-13 2.615803871047263 0.9999879607273354 0.0026360803327795065 2.4624712339434596 0.44189460849817147 4.912562947939025 0.0021598026678296247 1.7942882662401916e-11 10.746107782930538 2.6158038710467224 LALK(ub)WHPDKNPENKEEAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LALKWHPDKNPENKEEAER 19 3 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 79450000.0 11389000.0 30021000.0 38040000.0 True False 14743285.010752954 28350304.959420078 31117110.323360935 1.0 1.922929994146006 2.1105954541790246 23.813554677158464 -10.795264234073867 0.3122193019166757 4.859449013591826e-12 2.161020754004901 0.9991992753903944 0.013735147457671551 2.5113936450853203 0.15572958509965523 1.934827913989046 0.0641178223580171 1.602270238503319e-11 10.795264234073867 2.1610207540000412 LALK(ub)YHPDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LALKYHPDK 9 1 P31689;P31689-2;F5GWV1;F8WF76;F5H300;C9JDE6;Q9H3Z4-2;Q9H3Z4;F5H170;Q8WW22;Q8WW22-2 P31689;F5H170 DNAJA1;DNAJA4;DNAJC5 DnaJ homolog subfamily A member 1;DnaJ homolog subfamily C member 5;DnaJ homolog subfamily A member 4 1 9323300.0 2102300.0 2668700.0 4552300.0 True False 2756135.658702158 2270540.362511127 4081271.6647450547 1.0 0.8238129916944313 1.4807949136534493 21.394215469456434 -6.835332167066307 1.3039071374792546 0.9061461235017982 1.500480254550821 0.9161242913649034 0.08041251595601985 0.17432255305276886 0.5777234424941299 0.048391818736505436 0.11138370169118655 1.4610592661413697e-07 6.835332167066307 0.5943341310490227 LALK(ub)YHPDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LALKYHPDK 9 1 P31689;P31689-2;F5GWV1;F8WF76;F5H300;C9JDE6;Q9H3Z4-2;Q9H3Z4;F5H170;Q8WW22;Q8WW22-2 P31689;F5H170 DNAJA1;DNAJA4;DNAJC5 DnaJ homolog subfamily A member 1;DnaJ homolog subfamily C member 5;DnaJ homolog subfamily A member 4 1 18659400.0 2676300.0 4588100.0 11395000.0 True False 2591342.321432554 6420152.256625415 8410307.657327557 1.0 2.477539228810266 3.2455409645292033 21.305268180292355 -9.023769698167998 0.22970932791513357 4.6003886186777777e-23 3.869487609562991 0.999337172790259 0.023991344515295984 0.4890298052854991 0.07795993997943584 0.737010723441331 0.35593714782458574 9.467390741265123e-10 9.023769698167998 3.869487609562991 LALK(ub)YHPDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LALKYHPDK 9 1 P31689;P31689-2;F5GWV1;F8WF76;F5H300;C9JDE6;Q9H3Z4-2;Q9H3Z4;F5H170;Q8WW22;Q8WW22-2 P31689;F5H170 DNAJA1;DNAJA4;DNAJC5 DnaJ homolog subfamily A member 1;DnaJ homolog subfamily C member 5;DnaJ homolog subfamily A member 4 1 9562100.0 2102300.0 2402200.0 5057600.0 True False 2879577.1225213017 2296062.8609868907 3863099.0445416276 1.0 0.7973611274479437 1.341550818114284 21.457425530979325 -6.805839200460873 1.4317010084840047 0.889009624420561 1.3502151169528926 0.8487644209264605 0.08733083076623108 0.21251820899594015 0.8592549999848397 0.04797148059302061 0.1112043525864434 1.5637265124381203e-07 6.805839200460873 0.4612054925323317 LALK(ub)YHPDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LALKYHPDK 9 1 P31689;P31689-2;F5GWV1;F8WF76;F5H300;C9JDE6;Q9H3Z4-2;Q9H3Z4;F5H170;Q8WW22;Q8WW22-2 P31689;F5H170 DNAJA1;DNAJA4;DNAJC5 DnaJ homolog subfamily A member 1;DnaJ homolog subfamily C member 5;DnaJ homolog subfamily A member 4 1 14508600.0 2676300.0 5267400.0 6564900.0 True False 2225462.030192781 5239023.470702966 7937590.237331954 1.0 2.354128445969997 3.5667156436024925 21.08567345572663 -6.972432968795604 0.19134823882165028 0.1925142064042577 5.761502519807039 0.9999956632747132 0.0021832404564664067 0.07552085817637118 0.006114122219111946 0.04232121481490526 0.13169547431836212 1.0655333107707049e-07 6.972432968795604 5.568988313402782 LALK(ub)YHPDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LALKYHPDK 9 1 P31689;P31689-2;F5GWV1;F8WF76;F5H300;C9JDE6;Q9H3Z4-2;Q9H3Z4;F5H170;Q8WW22;Q8WW22-2 P31689;F5H170 DNAJA1;DNAJA4;DNAJC5 DnaJ homolog subfamily A member 1;DnaJ homolog subfamily C member 5;DnaJ homolog subfamily A member 4 1 8696900.0 3037200.0 3343200.0 2316500.0 True False 3931715.2721625133 3157147.981091008 1894920.7692972037 1.0 0.8029950702291117 0.4819577813057057 21.90672741737281 -6.963843981089425 0.3773732133451013 1.022713924841578 0.25093351873129927 0.999887286437207 0.00226665981520899 0.07835555077415235 0.01625722315968191 0.004189993582896119 0.027162041264521656 1.08681598867954e-07 6.963843981089425 -0.7717804061102786 down LALK(ub)YHPDK(ub)NPNEGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LALKYHPDKNPNEGEK 16 2 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 2 8244400.0 1573800.0 2555800.0 4114800.0 True False 1523840.5804545665 3576344.2683209255 3037010.438646021 1.0 2.346928093524121 1.9929974812326305 20.53928054970277 -10.533304245374554 5.328567364299751 0.9961862495224234 2.169962787378379 0.9357721287907136 0.1444915674108445 0.006553351710723058 0.0005739660562797501 0.1400504841174109 0.046634452854131724 2.928840724486434e-11 10.533304245374554 1.1737765378559555 LALK(ub)YHPDK(ub)NPNEGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LALKYHPDKNPNEGEK 16 2 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 2 15663700.0 3667000.0 7958000.0 4038700.0 True False 5563107.093609712 6537832.723862198 3240449.1747749043 1.0 1.175212451216721 0.5824890875275756 22.40745944804755 -6.827521752348365 1.338910762765868 1.0937948977466123 0.5673276331417264 0.900833976773738 0.07829403534173893 0.18388887053312386 0.645578788221396 0.04592390066601593 0.10570249905835023 1.487572864697298e-07 6.827521752348365 -0.5264672646048859 LALK(ub)YHPDK(ub)NPNEGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LALKYHPDKNPNEGEK 16 2 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 2 6962300.0 1573800.0 2897200.0 2491300.0 True False 1308684.4311614546 2881592.208550823 3012219.3115302813 1.0 2.2018999691112824 2.301715554801048 20.319685825137046 -10.7562112880329 0.46754232444841504 2.8740224947032436e-19 2.3010204273998465 0.9996306352981086 0.011368208495143728 2.337883544314365 0.2247256961574811 2.6592118668236613 0.021627580835339992 1.753027431292846e-11 10.7562112880329 2.3010204273998465 LALK(ub)YHPDKNPNEGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LALKYHPDKNPNEGEK 16 2 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 62688000.0 14293000.0 19065000.0 29330000.0 True False 18738261.413608875 16220576.314787934 26295212.953226414 1.0 0.8656393438404887 1.4032898982895614 24.159483766284296 -6.840537900306943 1.279989408305053 0.9285299462245847 1.42115230307089 0.9253605930083714 0.06241694903115134 0.1681715184614754 0.5349976601481655 0.038234709852604194 0.08809374460075653 1.4436506133072983e-07 6.840537900306943 0.4926223568463052 LALK(ub)YHPDKNPNEGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LALKYHPDKNPNEGEK 16 2 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 140686000.0 17950000.0 37658000.0 85078000.0 True False 17380187.075333245 52695035.783875726 62793519.51470935 1.0 3.0319026806485256 3.6129369173378336 24.050940275201768 -9.713261809900953 0.3393623557882266 2.6124043955043862e-24 3.760585738007622 0.9986383824876541 0.04133555998640625 1.0668952883872542 0.14404631061593562 1.3319059096543342 0.17703803141479557 1.9352549639448203e-10 9.713261809900953 3.760585738007622 LALK(ub)YHPDKNPNEGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LALKYHPDKNPNEGEK 16 2 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 212520000.0 44999000.0 96135000.0 71386000.0 True False 68266772.86756015 78978958.14381659 57276525.81040467 1.0 1.1569165323961987 0.8390103033216917 26.02468021808162 -6.772498552409444 1.5648327754390212 1.0897184921206138 0.8370496095002 0.7399980105361403 0.06617952240016306 0.26243447451004626 1.268563633634321 0.0333279056203583 0.07915565639273257 1.6885014875912658e-07 6.772498552409444 -0.25266888262041376 LALK(ub)YHPDKNPNEGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LALKYHPDKNPNEGEK 16 2 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 66279000.0 14293000.0 18762000.0 33224000.0 True False 19577508.35380153 17933032.80236285 25377175.46975855 1.0 0.9160017954419947 1.2962413301604263 24.222693827807188 -6.848770869972401 1.2409974772729495 0.9552186181341759 1.3110863116033 0.9385023468605541 0.040445212117515186 0.1588109109302355 0.4712735291402525 0.025510314090138514 0.05898828739840649 1.4165409376392554e-07 6.848770869972401 0.35586769346912417 LALK(ub)YHPDKNPNEGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LALKYHPDKNPNEGEK 16 2 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 111460000.0 17950000.0 37032000.0 56478000.0 True False 14926220.319829779 36832501.2657235 68287288.67523257 1.0 2.4676375181726877 4.574988658348528 23.831345550636044 -6.965973067085411 0.3409392058711282 0.7739001033867952 6.3388589914848295 0.9999318216609581 0.012115116885186121 0.07763228579567913 0.013704163073615182 0.02966353319142891 0.18227541623448415 1.0815010188583395e-07 6.965973067085411 5.564958888098034 LALK(ub)YHPDKNPNEGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LALKYHPDKNPNEGEK 16 2 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 169890000.0 44999000.0 68591000.0 56300000.0 True False 58252092.562900335 64773850.55366516 46053977.68678285 1.0 1.1119574886296602 0.7905978250833476 25.79580654017407 -6.81257537964222 1.4035010846980098 1.0608320469642532 0.7846280535560032 0.8665023565746477 0.048664007453773035 0.2032985801444899 0.7887423198854719 0.02725905176398775 0.06299077418360716 1.539659267224332e-07 6.81257537964222 -0.27620399340824997 LALSLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LALSLFR 7 0 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 0 4573600.0 2330600.0 1258100.0 984900.0 False True 2256616.378705944 1760465.8909048263 726925.1436333404 1.0 0.7801352092970117 0.3221305803205219 21.1057297527726 -6.959240972224241 0.44600724726873675 1.0153875447731895 0.06884217627059538 0.9997409893348561 0.004544469460831247 0.07997345617692352 0.02214209393594471 0.006086557287795404 0.03790819604770899 1.0983962152384026e-07 6.959240972224241 -0.9465453685025941 down LALSLFRPGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LALSLFRPGGR 11 1 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 0 11207300.0 3792500.0 4929300.0 2485500.0 False True 4972004.22662224 4193867.6542609106 2228324.3025995325 1.0 0.8434963976509005 0.4481742575093018 22.245396092127354 -6.955239824244135 0.4980097091033903 1.0080554987081585 0.26662218366543045 0.9995509054391597 0.0049209121149061215 0.08144744540276415 0.027764097643319007 0.005792791113878949 0.03260852442676475 1.1085624805686514e-07 6.955239824244135 -0.741433315042728 down LALSLFRPGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LALSLFRPGGR 11 1 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 0 16711200.0 5971500.0 2064700.0 8675000.0 False True 5781938.001133845 2889145.477268259 6402757.25557845 1.0 0.4996846172860543 1.107372174229966 22.463121708416498 -6.687994547177604 1.8737264965838072 0.6857439118074221 1.1052124434446242 0.3609917556261659 0.21168537233289753 0.4209823782847125 2.864050525635375 0.09043605402996507 0.23608276927508778 2.0511879325335837e-07 6.687994547177604 0.4194685316372021 LALSLFRPGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LALSLFRPGGR 11 1 Q9H7N4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 0 15082600.0 3792500.0 4595400.0 6694700.0 False True 5194689.738458848 4392360.033044359 5113549.741674471 1.0 0.8455480989606662 0.9843802034636144 22.308606153650246 -10.323983026372682 6.38019062676695 1.0000041350893034 0.9149641512160654 0.3334321040084458 0.05667796932482904 3.333940190904422e-06 3.532708778678295e-07 0.05488087687695298 0.018292735940993135 4.7426052052688084e-11 10.323983026372682 -0.08503998387323797 LALTLRPCAPILGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LALTLRPCAPILGAK 15 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 23416900.0 0.0 15038000.0 8378900.0 False True 0.0 12794389.017664878 7511931.804084159 0.0 LALTLRPCAPILGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LALTLRPCAPILGAK 15 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 11481400.0 7669700.0 1866900.0 1944800.0 False True 7426229.571681518 2612362.905754889 1435398.5372506033 1.0 0.35177513441230346 0.19328766009661436 22.824198484140727 -13.999999999999776 0.19783648291375958 4.574149706915241 0.0881364097226153 0.9994869691006899 0.007904514375960245 12.488968705587194 0.14104313846591332 17.257318683481007 0.1025692254915713 1.0000000000005154e-14 13.999999999999776 -4.486013297192626 LALTLRPCAPILGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LALTLRPCAPILGAK 15 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 35606300.0 9960300.0 15087000.0 10559000.0 False True 15110503.295467893 12394606.974730987 8472009.021825885 1.0 0.8202643374856027 0.5606702077466145 23.849048378306808 -6.965878336707499 0.3426433677660671 1.0273083348685186 0.34496449472779145 0.9999301219470889 0.0015075120645174044 0.07766414644496034 0.013815979121216466 0.003635683585196675 0.022426083007265372 1.0817369467341475e-07 6.965878336707499 -0.6823438401407271 LALTLRPCAPILGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LALTLRPCAPILGAK 15 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 40095000.0 0.0 15124000.0 24971000.0 False True 0.0 14455771.671620071 19073364.093888175 0.0 LALTLRPCAPILGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LALTLRPCAPILGAK 15 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 17087200.0 7669700.0 1025800.0 8391700.0 False True 6377695.375320241 1020273.811794642 10146365.6711631 1.0 0.15997531267215964 1.5909141271354035 22.604603759575003 -6.747562184366817 1.6585616962055463 0.5046398973285925 1.593303639843193 0.638616195593827 0.35294941373790056 0.3042760963411518 1.6459907661266184 0.1681525859908733 0.4093282211462097 1.788289454914362e-07 6.747562184366817 1.0886637425146004 LALTLRPCAPILGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LALTLRPCAPILGAK 15 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 37213300.0 9960300.0 12287000.0 14966000.0 False True 12893804.69686563 11603217.648858938 12242341.564127747 1.0 0.8999064218554186 0.9494747168850597 23.620174700399257 -10.205487715917041 4.643994232481473 1.0000153864570502 0.9246905693697249 0.7547650714075548 0.0202361717088197 3.224403987068325e-06 5.516253589455192e-07 0.019597591692321954 0.006531196334688992 6.230347698094528e-11 10.205487715917041 -0.0753248170873253 LALVFNIPLHQINQVYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LALVFNIPLHQINQVYR 17 0 Q9NZI7;Q9NZI7-4 Q9NZI7 UBP1 Upstream-binding protein 1 0 34059800.0 13781000.0 9787800.0 10491000.0 False True 13343529.698338028 13696119.582702719 7743092.376746243 1.0 1.0264240341450739 0.5802881660098277 23.669637010247605 -6.892832081234198 1.0054547118141883 1.0223693089633161 0.5397140819101824 0.9826507510134637 0.026918537683994256 0.11687629285385777 0.20865453795184918 0.020319230774545265 0.05120213779672388 1.2798760690601807e-07 6.892832081234198 -0.4826552270531337 LALVFNIPLHQINQVYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LALVFNIPLHQINQVYR 17 0 Q9NZI7;Q9NZI7-4 Q9NZI7 UBP1 Upstream-binding protein 1 0 444710000.0 145930000.0 136380000.0 162400000.0 False True 221386478.91204393 112041923.45819663 130301568.8175513 1.0 0.506091989035656 0.588570582349429 27.721991871903935 -10.772172219896616 7.075277438622102 1.011062052806104 0.5473312856925425 0.9757058495829217 0.03367174472021205 0.005829762008698198 0.00018772123166054195 0.032348593023718876 0.010867508878260736 1.6897707185533386e-11 10.772172219896616 -0.46373076711356154 LALVFNIPLHQINQVYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LALVFNIPLHQINQVYR 17 0 Q9NZI7;Q9NZI7-4 Q9NZI7 UBP1 Upstream-binding protein 1 0 6357270.0 1907900.0 807270.0 3642100.0 False True 2613302.189058836 771602.1421150987 2781910.991404035 1.0 0.2952594404679186 1.064519443274152 21.317442529592185 -12.108174105492584 18.943487600890187 0.936006074853914 0.7119004976858405 0.0 0.3563384227487248 0.0 0.0 0.0 0.10384279664519179 7.795175449722952e-13 12.108174105492584 -0.22410557716807344 LALVFNIPLHQINQVYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LALVFNIPLHQINQVYR 17 0 Q9NZI7;Q9NZI7-4 Q9NZI7 UBP1 Upstream-binding protein 1 0 42741000.0 13781000.0 12591000.0 16369000.0 False True 11459512.101814723 12523169.783882182 19791682.218295313 1.0 1.0928187581301143 1.7270964106020807 23.45004228568188 -6.93314861350499 0.7204768615905676 0.9913907295350148 1.868406141090279 0.9971217410782686 0.017334585326556292 0.09103541660367157 0.06990997525131976 0.016099592205763565 0.056430423945668474 1.1664104086701103e-07 6.93314861350499 0.8770154115552642 LALVFNIPLHQINQVYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LALVFNIPLHQINQVYR 17 0 Q9NZI7;Q9NZI7-4 Q9NZI7 UBP1 Upstream-binding protein 1 0 354561000.0 145930000.0 134300000.0 74331000.0 False True 188909261.71035033 126826086.9408121 60803520.700466365 1.0 0.6713598147203139 0.32186627669793566 27.493118193996384 -7.255668958156191 0.29021138784264267 1.0815084953673246 1.9048485194559523e-15 0.9999071400762101 0.002668217928761992 0.09830190962174953 0.01784756644184161 0.012027230741359314 0.04464289226866911 5.550486386925431e-08 7.255668958156191 -1.0815084953673226 down LALYVYEYLLHVGAQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LALYVYEYLLHVGAQK 16 0 A0A087X159;P81877-2;P81877-4;P81877-5;P81877-3;P81877;D6RAC5;A0A087WVT6;Q9BWW4-2;Q9BWW4-3;Q9BWW4 A0A087X159;Q9BWW4-2 SSBP2;SSBP3 Single-stranded DNA-binding protein 2;Single-stranded DNA-binding protein 3 0 34071100.0 6178100.0 15130000.0 12763000.0 False True 9372629.379610065 12429933.28877044 10240387.455778386 1.0 1.3261949006339102 1.092584272888898 23.160022404911803 -10.352923528432331 5.430408579830771 0.9999358745310288 1.209389586761283 0.5171841579616822 0.09537113941110552 7.407120926265171e-05 8.826172791208005e-06 0.0923709318899929 0.03078090288733439 4.436867624355376e-11 10.352923528432331 0.2094537122302541 LALYVYEYLLHVGAQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LALYVYEYLLHVGAQK 16 0 A0A087X159;P81877-2;P81877-4;P81877-5;P81877-3;P81877;D6RAC5;A0A087WVT6;Q9BWW4-2;Q9BWW4-3;Q9BWW4 A0A087X159;Q9BWW4-2 SSBP2;SSBP3 Single-stranded DNA-binding protein 2;Single-stranded DNA-binding protein 3 0 21228800.0 6178100.0 8326100.0 6724600.0 False True 7997672.238557624 7862745.215769878 5500791.800222736 1.0 0.983129213255671 0.6877991040571576 22.931148727004253 -6.918652021883523 0.834680033984258 1.0068382680013486 0.6416229689598337 0.993797854329689 0.01129028467186202 0.098971286865759 0.10977757689941695 0.009658923030571023 0.028569817881167067 1.2060018614035976e-07 6.918652021883523 -0.36521529904151484 LAMAIPDKWIQLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAMAIPDKWIQLLK 14 1 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 0 2148430.0 560760.0 539070.0 1048600.0 False True 735161.790407565 458642.85727840214 940100.93088146 1.0 0.6238665600726283 1.278767399432279 19.48770225980419 -6.751013512115363 1.6467401402593127 0.7790913553911524 1.2801184714642364 0.6530586835673312 0.15806000187701094 0.29828101388668216 1.591858476850732 0.07582331396154487 0.18383637842685055 1.7741342817545334e-07 6.751013512115363 0.501027116073084 LAMAIPDKWIQLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAMAIPDKWIQLLK 14 1 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 0 1890800.0 0.0 0.0 1890800.0 False True 0.0 0.0 1395542.7572158794 0.0 LAMAIPDKWIQLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAMAIPDKWIQLLK 14 1 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 0 3740900.0 560760.0 980940.0 2199200.0 False True 768088.125969199 937598.827265209 1679794.2539457344 1.0 1.2206917351861362 2.186981151187716 19.550912321327083 -6.942804614842808 0.6329443406535536 0.9894557422139107 2.4705573931574065 0.9985085488546999 0.019906930510986718 0.08651033277140831 0.04895768589309595 0.019817464175353898 0.08219436641506193 1.1407628910333713e-07 6.942804614842808 1.4811016509434958 up LAMAIPDKWIQLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAMAIPDKWIQLLK 14 1 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 0 3595000.0 0.0 1245700.0 2349300.0 False True 0.0 1238989.16684791 2840527.7680640947 0.0 LAMQEFMILPVGAANFR ddPTM_RPMI8226_Bortezomib_1h_R1 3 LAMQEFMILPVGAANFR 17 0 P06733;A0A2R8Y6G6;K7EM90;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 0 41564290.0 7342890.0 23696230.0 10525170.0 False True 9626599.898647916 20160844.85118108 9436126.372959755 1.0 2.0942851124427357 0.9802138317065704 23.198594899528803 -6.650266568161875 2.007436907411713 1.7099319086657663 0.9848863854282712 0.19516866127039367 0.46702232159482177 0.5078942514462125 3.9233524874330086 0.18865102056052221 0.5173400762852072 2.2373474423940702e-07 6.650266568161875 -0.725045523237495 LAMQEFMILPVGAANFR ddPTM_RPMI8226_Bortezomib_2h_R1 4 LAMQEFMILPVGAANFR 17 0 P06733;A0A2R8Y6G6;K7EM90;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 0 549835400.0 250866600.0 105018900.0 193949900.0 False True 242902977.10043427 146953494.43632877 143148602.81771964 1.0 0.6049884451418938 0.5893242006602961 27.855804931335797 LAMQEFMILPVGAANFR ddPTM_RPMI8226_Carfilzomib_1h_R1 4 LAMQEFMILPVGAANFR 17 0 P06733;A0A2R8Y6G6;K7EM90;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 0 215001280.0 42414890.0 42806890.0 129779500.0 False True 58096821.05230346 40915540.056344666 99128254.9927019 1.0 0.7042646966777956 1.7062595370486557 25.791955888468703 -6.827651168222575 1.3382987110100368 0.841699525655141 1.7319646071732153 0.9011030361213376 0.1321915473614594 0.18373217387572816 0.644389950815838 0.07757122836486727 0.17854610875263377 1.4871296473191131e-07 6.827651168222575 0.8902650815180744 LAMQEFMILPVGAANFR ddPTM_RPMI8226_Carfilzomib_2h_R1 3 LAMQEFMILPVGAANFR 17 0 P06733;A0A2R8Y6G6;K7EM90;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase;Enolase 0 414210500.0 243455000.0 94109600.0 76645900.0 False True 202443619.38518977 93602612.90550704 92672203.319399 1.0 0.4623638580942836 0.45776796325238317 27.592944931990232 LANFIPWGPASIQVALSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LANFIPWGPASIQVALSR 18 0 P23258;Q9NRH3 P23258 TUBG1;TUBG2 Tubulin gamma-1 chain;Tubulin gamma-2 chain 0 147475000.0 50467000.0 47265000.0 49743000.0 False True 76562128.63190651 38830191.46686948 39911274.24686859 1.0 0.5071723077809959 0.521292641153605 26.190127605373046 -9.938609362638601 5.749610962737804 1.000000383570518 0.5142324744870137 0.9993666853832991 0.00576460196156362 2.8344274009199476e-08 5.222091826317343e-09 0.005581556255991441 0.0018605172826810987 1.1518359716757498e-10 9.938609362638601 -0.4857679090835043 LANFIPWGPASIQVALSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LANFIPWGPASIQVALSR 18 0 P23258;Q9NRH3 P23258 TUBG1;TUBG2 Tubulin gamma-1 chain;Tubulin gamma-2 chain 0 104042000.0 50467000.0 27739000.0 25836000.0 False True 65330526.35329437 26195300.265459295 21134113.099746402 1.0 0.4009657005333214 0.32349522159759375 25.961253927465496 -13.999999999999998 0.28835322955513815 6.114271428149647 0.3020317854913157 0.9996237781557655 0.005863664960023117 15.868584625072236 0.17025396527118816 48.09570043628435 0.029477936065230356 1.0000000000000041e-14 13.999999999999998 -5.812239642658331 LANLPEEVIQK(ub)GHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LANLPEEVIQKGHR 14 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WYT6 P52701 MSH6 DNA mismatch repair protein Msh6 1 26200600.0 3234400.0 2465200.0 20501000.0 True False 4186994.5595556567 2328009.4529150403 16770028.35802372 1.0 0.5560096675076882 4.005266335909314 21.997483612812665 -6.874552286734682 1.109672610227551 0.740431590138649 4.22560217553941 0.9690219656847616 0.26965941822379125 0.13256797409077165 0.30234511570052464 0.18801563434646562 0.44902662047455366 1.334896865438707e-07 6.874552286734682 3.485170585400761 up LANSEFLK(ub)FVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LANSEFLKFVR 11 1 B4E0T2;P50542-3;P50542;P50542-4;F5H3X7 B4E0T2 PEX5 Peroxisomal targeting signal 1 receptor 1 8982200.0 2205800.0 2635500.0 4140900.0 True False 2855451.5828184104 2488832.1082093064 3387298.6892220117 1.0 0.8716071822701892 1.186256741176698 21.44528749171568 -6.795954780261175 1.4727354391980132 0.9287923089538646 1.1901608570644662 0.8199587105152051 0.054811510136244815 0.22658981843921913 0.970688831241056 0.029287128076341228 0.06827482166565137 1.599724586941105e-07 6.795954780261175 0.2613685481106016 LANVQLLDTDGGFVHSDGAISCHDMFDFLHLTGGGYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LANVQLLDTDGGFVHSDGAISCHDMFDFLHLTGGGYAK 38 0 P68402;J3KNE3 P68402 PAFAH1B2 Platelet-activating factor acetylhydrolase IB subunit beta 0 120021000.0 27922000.0 58440000.0 33659000.0 False True 42359715.3716308 48010925.4061959 27006283.8967362 1.0 1.1334100096043098 0.6375463966130159 25.336189559648577 -6.8350867563278515 1.3050447271572394 1.071074333450961 0.622763445295821 0.9156663600467627 0.06084236135800975 0.1746171570528954 0.5798100741592449 0.03658407026737913 0.08420250827819648 1.4618851135208315e-07 6.8350867563278515 -0.44831088815514 LAPDYDALDVANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAPDYDALDVANK 13 0 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9;K7EMA7 P62750 RPL23A 60S ribosomal protein L23a 0 24946400.0 8605100.0 2905300.0 13436000.0 False True 8331935.810693588 4065401.440939348 9916708.528640024 1.0 0.48793000009933174 1.1902046239857569 22.990220294210324 -6.711177059829211 1.7907445973719942 0.6855737434746474 1.188631626192205 0.47079526913941505 0.215744071046839 0.3727225770994186 2.330568701561967 0.0958429478430003 0.24316331565163932 1.9445671290677396e-07 6.711177059829211 0.5030578827175576 LAPDYDALDVANK(ub)IGII ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAPDYDALDVANKIGII 17 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EMA7 P62750 RPL23A 60S ribosomal protein L23a 1 57708000.0 17470000.0 14060000.0 26178000.0 True False 16915424.412594523 19674231.321931392 19321196.476833746 1.0 1.1630941584464636 1.1422235709585853 24.011836039408113 -10.073526945095763 4.521544864000078 0.9999901228563478 1.1526588647102407 0.9861757657774879 0.008520381689152761 8.484216102986336e-07 1.7383565383856061e-07 0.008250357801396045 0.0027499413657118346 8.442538599245221e-11 10.073526945095763 0.1526687418538929 LAPDYDALDVANK(ub)IGII ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAPDYDALDVANKIGII 17 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EMA7 P62750 RPL23A 60S ribosomal protein L23a 1 154548000.0 30985000.0 54932000.0 68631000.0 True False 47006510.306925796 45128955.41432502 55066052.76796416 1.0 0.9600575562758986 1.1714558772479415 25.486357245194856 -6.857812435657979 1.196644337475058 0.9784406360158663 1.1812777911068169 0.9509323321738087 0.02031290642468432 0.14907718811447537 0.40687403606421935 0.013250244140669807 0.030859725329482293 1.3873548742919043e-07 6.857812435657979 0.20283715509095057 LAPDYDALDVANK(ub)IGII ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAPDYDALDVANKIGII 17 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EMA7 P62750 RPL23A 60S ribosomal protein L23a 1 50915000.0 17470000.0 17064000.0 16381000.0 True False 14527079.052224295 16972072.8450612 19806191.36281356 1.0 1.1683059467114654 1.3633980576281752 23.79224131484239 -6.969187186415381 0.27691793083923927 0.9553937670816881 1.582230156780585 0.9999753265053813 0.0007375677462619366 0.07656738036152079 0.009970789585435203 0.003668783795357437 0.017977734710859176 1.0735266090631159e-07 6.969187186415381 0.6268363896988969 LAPDYDALDVANK(ub)IGII ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAPDYDALDVANKIGII 17 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EMA7 P62750 RPL23A 60S ribosomal protein L23a 1 126383000.0 30985000.0 54009000.0 41389000.0 True False 40110693.305661656 51003351.672273435 33856626.68700283 1.0 1.2715649486186835 0.8440798175439151 25.257483567287306 -6.7350644122018855 1.7047285228404339 1.1624985671772587 0.8440881747801043 0.582576606013909 0.11412147099882397 0.32683373296220264 1.8629299522058766 0.05300208224297042 0.13077556614349448 1.840499008395214e-07 6.7350644122018855 -0.3184103923971544 LAPGK(ub)DEQVPIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAPGKDEQVPIR 12 1 E9PPS0;E9PIX2;Q9HAB3 E9PPS0 SLC52A2 Solute carrier family 52, riboflavin transporter, member 2 1 12209700.0 1326300.0 2385000.0 8498400.0 True False 1738792.1439074704 2029167.296657184 7619067.090409105 1.0 1.166998196861629 4.381815915781221 20.72965405178082 -6.917664903624603 0.8418708256224275 0.9229234385574249 4.873365829208105 0.9935071744071113 0.1254065087751363 0.09956516868470863 0.1128798510718717 0.10673526251911195 0.3129184132514711 1.2087461292972078e-07 6.917664903624603 3.9504423906506796 up LAPGK(ub)DEQVPIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAPGKDEQVPIR 12 1 E9PPS0;E9PIX2;Q9HAB3 E9PPS0 SLC52A2 Solute carrier family 52, riboflavin transporter, member 2 1 10335300.0 1255600.0 1641900.0 7437800.0 True False 1215741.665280691 2297519.2323953873 5489617.050782873 1.0 1.8898087463876914 4.515446996311859 20.213405270298743 -6.95182188949387 0.5384707914310245 0.9609502150095444 5.565240399552687 0.9993366128130499 0.0384375410753837 0.08276230820243938 0.032997701485143645 0.04236627569018228 0.21738779637933855 1.1173213836382488e-07 6.95182188949387 4.604290184543142 LAPGK(ub)DEQVPIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAPGKDEQVPIR 12 1 E9PPS0;E9PIX2;Q9HAB3 E9PPS0 SLC52A2 Solute carrier family 52, riboflavin transporter, member 2 1 23962200.0 2392200.0 10589000.0 10981000.0 True False 3629142.2932460173 8699310.217765387 8810600.536856726 1.0 2.397070578895504 2.427736314790857 21.791197193167008 -10.775341608559192 0.6813680231788608 2.584091057791977e-17 2.422670071198641 0.999949184923324 0.004747065695812632 2.4318324974493875 0.3444760274501 3.9961156463442786 0.004863366760863344 1.6774840190099107e-11 10.775341608559192 2.422670071198641 LAPGK(ub)DEQVPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAPGKDEQVPIR 12 1 E9PPS0;E9PIX2;Q9HAB3 E9PPS0 SLC52A2 Solute carrier family 52, riboflavin transporter, member 2 1 10051400.0 1326300.0 1000600.0 7724500.0 True False 1816668.9519098157 956390.1834582816 5900132.191071219 1.0 0.5264526497537452 3.247775102265367 20.79286411330371 -6.862018890578489 1.175589407838347 0.7415934941522084 3.384666691865918 0.9560420750886195 0.24888399096661115 0.14473085414718304 0.37894946821520836 0.16499161223810185 0.3860320485148032 1.3739822093826255e-07 6.862018890578489 2.6430731977137096 up LAPGK(ub)DEQVPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAPGKDEQVPIR 12 1 E9PPS0;E9PIX2;Q9HAB3 E9PPS0 SLC52A2 Solute carrier family 52, riboflavin transporter, member 2 1 8258000.0 1255600.0 1300000.0 5702400.0 True False 1044087.0325113232 1292996.6419702028 6894745.47508139 1.0 1.238399292116656 6.603611825824123 19.99381054573302 -6.916204159256786 0.852393978716918 0.864665235013579 7.397552211782855 0.9930601126919739 0.21552991007912983 0.1004572156151464 0.11756451182375795 0.18206048719938825 0.5270548662528547 1.2128185776237997e-07 6.916204159256786 6.5328869767692765 up LAPGK(ub)DEQVPIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAPGKDEQVPIR 12 1 E9PPS0;E9PIX2;Q9HAB3 E9PPS0 SLC52A2 Solute carrier family 52, riboflavin transporter, member 2 1 20018800.0 2392200.0 9836300.0 7790300.0 True False 3096750.0573117244 9288901.258197395 6372545.335228155 1.0 2.9995644098771894 2.057817136446632 21.562323515259457 -10.04349709764156 5.9152872278295145 0.9999966402751204 2.528690773162054 0.7784302680175028 0.3844667144275391 1.7035392663347006e-05 2.7560694580628703e-06 0.37225911570690845 0.12408609851233722 9.046964837387283e-11 10.04349709764156 1.5286941328869337 LAPGTIVEVWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAPGTIVEVWK 11 0 P07686;Q5URX0;H0YA83;H0Y9B6 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 3318790.0 846890.0 1331900.0 1140000.0 False True 1110280.9912944252 1133185.7117055373 1022043.7356521675 1.0 1.0206296609513315 0.9205270950920397 20.082493411165352 -6.852997256252469 1.2206856777234993 1.011043117215915 0.9162914382244707 0.9445286697229325 0.010164277778808838 0.15419922683283838 0.4406689520875757 0.006510498451003974 0.01509605141480564 1.402822567163158e-07 6.852997256252469 -0.09475167899144443 LAPGTIVEVWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAPGTIVEVWK 11 0 P07686;Q5URX0;H0YA83;H0Y9B6 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 2634040.0 1070400.0 536440.0 1027200.0 False True 1036420.7379073362 750643.2894976448 758145.5046605408 1.0 0.7242650229223394 0.7315036036343039 19.98317835735809 -10.306487879382466 5.596011190053767 1.0000357974417418 0.7278843132783178 0.9994695649901387 0.002955138201057971 1.3199804074223203e-06 1.6358365800164766e-07 0.0028616760556254483 0.0009537667532012306 4.9375569816333706e-11 10.306487879382466 -0.27215148416342394 LAPITSDPTEATAVGAVEASFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAPITSDPTEATAVGAVEASFK 22 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 63779000.0 16709000.0 28572000.0 18498000.0 False True 21905660.8101862 24309168.972783692 16584004.405345457 1.0 1.1097208700264296 0.7570647856299246 24.38480040013234 -6.823124692898567 1.3583421170286627 1.0589586919126774 0.748840115295627 0.8914134988910551 0.04855723474551532 0.18945026231005693 0.685990237717848 0.028085260035352142 0.06468306579376076 1.502710451917371e-07 6.823124692898567 -0.31011857661705045 LAPITSDPTEATAVGAVEASFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAPITSDPTEATAVGAVEASFK 22 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 217581000.0 56842000.0 43019000.0 117720000.0 False True 55037581.82373778 60196711.04112141 86885600.4756999 1.0 1.0937382974765526 1.5786594831502214 25.71391374821337 -6.939049067846841 0.6683551254632137 0.9944572612796645 1.705847084721062 0.9980366351334898 0.011236648279207844 0.0882031833270421 0.05660613666232153 0.010860766757546757 0.041914099714734254 1.1506703755323783e-07 6.939049067846841 0.7113898234413976 LAPITSDPTEATAVGAVEASFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAPITSDPTEATAVGAVEASFK 22 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 673747800.0 52794800.0 526030000.0 94923000.0 False True 80093571.41688187 432155836.6088511 76161427.44377114 1.0 5.3956369901338 0.9509056232160734 26.25518311586955 -6.6486870896054775 2.01307491738721 3.85520163168903 0.9694683081844085 0.18889355616483683 1.876692526875135 0.5116798193593095 3.9729980434324608 0.756431658364352 2.0787491212096523 2.2454992295805897e-07 6.6486870896054775 -2.8857333235046214 LAPITSDPTEATAVGAVEASFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAPITSDPTEATAVGAVEASFK 22 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 81759000.0 16709000.0 16902000.0 48148000.0 False True 22886768.84374662 16155213.752560338 36776434.03918656 1.0 0.7058756901358947 1.6068862446362773 24.448010461655233 -6.818789637729596 1.3771490088500375 0.8412737553978686 1.626043250054368 0.8815693210845024 0.12910333499353163 0.19505750998558152 0.7272338076985576 0.07367577849167277 0.16986426723578305 1.517785369802348e-07 6.818789637729596 0.7847694946564994 LAPITSDPTEATAVGAVEASFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAPITSDPTEATAVGAVEASFK 22 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 114478000.0 56842000.0 27750000.0 29886000.0 False True 47266641.527563505 27600505.242056288 36135024.422748715 1.0 0.5839320152662227 0.7644931658974883 25.494319023647645 -10.229560319654036 5.502253216615234 1.000018783654306 0.6742125905818351 0.812758251463169 0.07371378106947406 1.6986187145814463e-05 2.378538795125627e-06 0.07137717251053068 0.023791020538993964 5.8944010337418e-11 10.229560319654036 -0.32580619307247083 LAPITSDPTEATAVGAVEASFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAPITSDPTEATAVGAVEASFK 22 0 P14618;P14618-3;B4DNK4 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 231403800.0 52794800.0 113180000.0 65429000.0 False True 68343909.3410923 106881433.50678413 53521593.358232975 1.0 1.563876496636414 0.7831216252368037 26.026309437962 -6.712907741345807 1.7845377387742354 1.3456143464952783 0.7847682139922652 0.47906050054238614 0.23750849855600184 0.3692494226755717 2.293902310616462 0.10583636301285437 0.2679606914831925 1.9368333683482842e-07 6.712907741345807 -0.5608461325030132 LAPNQTK(ub)ELEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAPNQTKELEEK 12 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6 P11171 EPB41 Protein 4.1 1 4648500.0 1930000.0 1507800.0 1210700.0 True False 2530248.6901465873 1282842.117358365 1085428.3778544567 1.0 0.5070023837396177 0.4289809069287863 21.270847759148403 -13.999999999999998 0.2594820186372603 4.5992516465745155 0.400322771766831 0.9995612785138799 0.00529518541582366 14.394209785934601 0.16119486821795975 27.15785123188978 0.03420311330971681 1.0000000000000041e-14 13.999999999999998 -4.1989288748076845 LAPNQTK(ub)ELEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAPNQTKELEEK 12 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6 P11171 EPB41 Protein 4.1 1 6226100.0 2021600.0 2339900.0 1864600.0 True False 1957425.4145678924 3274234.272417304 1376205.3231990302 1.0 1.6727249212405373 0.7030690993162729 20.900525905661404 -6.720115826343441 1.7590563637228522 1.4092282909168001 0.7045865031816234 0.5130101757195064 0.28308068279289716 0.3550839189827345 2.147372029731538 0.12778019947720606 0.3207132752882195 1.9049525993279503e-07 6.720115826343441 -0.7046417877351767 LAPNQTK(ub)ELEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAPNQTKELEEK 12 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6 P11171 EPB41 Protein 4.1 1 4639580.0 1930000.0 1775900.0 933680.0 True False 2643573.1562888827 1697434.8658840319 713164.0137432026 1.0 0.6420986920093165 0.26977275512373594 21.334057820671294 -7.433442043776478 0.3181905695931927 1.0724700009391586 4.018088547861815e-11 0.9996901941492783 0.005247533192199103 0.11844314003440541 0.030144823594070357 0.01846419486923445 0.06028876355861954 3.6860222821947185e-08 7.433442043776478 -1.0724700008989776 down LAPNQTK(ub)ELEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAPNQTKELEEK 12 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6 P11171 EPB41 Protein 4.1 1 5783730.0 2021600.0 2882700.0 879430.0 True False 1681049.972065062 2867170.3229288473 1063314.746975101 1.0 1.705583040703253 0.6325301238183224 20.68093118109568 -6.729345416710389 1.7257170963713466 1.4249257700506512 0.6332549411631928 0.5562022083761323 0.2966252957680587 0.33745728525283164 1.9685714051951315 0.13623226362575386 0.3382889925430954 1.8648958533582636e-07 6.729345416710389 -0.7916708288874584 LAPNQTK(ub)ELEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAPNQTKELEEK 12 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6 P11171 EPB41 Protein 4.1 1 16020300.0 5386800.0 5077400.0 5556100.0 True False 6973318.789702699 4794838.226606691 4544946.81040026 1.0 0.6875977380651366 0.6517623741957206 22.73341400617767 -13.999999999999908 0.30561777927701456 3.9436356195667126 0.6434478813694602 0.9996623230632987 0.0028739997163598646 16.963648916098673 0.17574466236569383 31.676970374207542 0.01264563779127041 1.0000000000002127e-14 13.999999999999908 -3.3001877381972524 LAQAK(ub)EENVGLHQTLDQTLNELNCI ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAQAKEENVGLHQTLDQTLNELNCI 25 1 P67936;A0A2R8YE05;K7ENT6;P67936-2;A0A5F9UN72;K7EPB9 P67936 TPM4 Tropomyosin alpha-4 chain 1 65703000.0 23800000.0 28307000.0 13596000.0 True False 36106340.01306551 23255394.68639951 10908744.640661513 1.0 0.6440806428451143 0.30212823112821885 25.105748850418554 -7.445920198576913 0.28276471643955725 1.0982534817309422 2.1099845063803224e-16 0.9998103160147489 0.003924134263113941 0.12099651914910634 0.02616153956653305 0.021018613640691745 0.060774026986642464 3.581622432137063e-08 7.445920198576913 -1.098253481730942 down LAQAK(ub)EENVGLHQTLDQTLNELNCI ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAQAKEENVGLHQTLDQTLNELNCI 25 1 P67936;A0A2R8YE05;K7ENT6;P67936-2;A0A5F9UN72;K7EPB9 P67936 TPM4 Tropomyosin alpha-4 chain 1 11403100.0 4401900.0 3109900.0 3891300.0 True False 3660374.8872344634 3093146.351433182 4704952.838661651 1.0 0.8450353984835031 1.2853745814588957 21.803559982931006 -6.811612790821091 1.407808515541623 0.9157047166901583 1.293360377999581 0.8639728828026337 0.06726390048857539 0.20461558873421085 0.7989696575977967 0.037566146854065716 0.08683378494376645 1.5430756183964542e-07 6.811612790821091 0.37765566130942274 LAQANGWGVMVSHR ddPTM_RPMI8226_Bortezomib_1h_R1 2 LAQANGWGVMVSHR 14 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 1604780310.0 611907010.0 592091100.0 400782200.0 False True 802216015.8259147 503753415.8330314 359313102.51832855 1.0 0.6279523294164058 0.4479006843915984 29.57941552819569 -13.999999999980924 0.09569043794379742 2.863030989793737 0.0374382941304097 0.9998150909928117 0.0031260906908089988 12.114643784828973 0.09122285505753797 4.509470747882535 0.36709571870423613 1.0000000000439247e-14 13.999999999980924 -2.8255926956633273 LAQANGWGVMVSHR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LAQANGWGVMVSHR 14 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 1146154600.0 633881300.0 217177700.0 295095600.0 False True 613759085.1005819 303897888.1767439 217801209.681761 1.0 0.49514197924571923 0.3548643351585876 29.19309723401714 -13.999999999999991 0.17967414050337227 3.616870429163228 0.2430588506763121 0.9994985345005203 0.006203867432559153 12.200530767743961 0.13436984375335165 11.145157120937846 0.10502702578942537 1.0000000000000205e-14 13.999999999999991 -3.373811578486916 LAQANGWGVMVSHR ddPTM_RPMI8226_Bortezomib_8h_R1 2 LAQANGWGVMVSHR 14 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 2109065300.0 504279100.0 626563700.0 978222500.0 False True 765028262.4404469 514748512.3704681 784876394.104848 1.0 0.6728490143990443 1.0259443116533833 29.510937805374134 -11.841879119344409 13.393483723413317 0.9021849605444324 0.8644569969722927 0.0 0.16448270168259305 0.0 0.0 0.0 0.04783604803231658 1.4391991063066852e-12 11.841879119344409 -0.0377279635721397 LAQANGWGVMVSHR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LAQANGWGVMVSHR 14 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 1678115710.0 611907010.0 490253900.0 575954800.0 False True 838145567.7621728 468592861.6451506 439926138.4014481 1.0 0.5590829083500155 0.5248803493360223 29.64262558971858 -13.999999999999998 0.36252697883030893 6.860705291428639 0.5209098795645716 0.9997778327885164 0.0032249441887629003 21.972544783364647 0.19479811476243258 99.74527008663712 0.009789032958046152 1.0000000000000041e-14 13.999999999999998 -6.339795411864067 LAQANGWGVMVSHR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LAQANGWGVMVSHR 14 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 1069657600.0 633881300.0 337957300.0 97819000.0 False True 527100386.65293163 336136656.94562817 118272500.63604552 1.0 0.6377089933097636 0.22438325531702152 28.973502509451418 -7.452669681102533 0.3679334890101781 1.0481886964117157 4.22670554892181e-15 0.9993598230505994 0.008017419507797642 0.11773930884222798 0.03878382053755158 0.017724344065944992 0.0626665499809823 3.5263898182420296e-08 7.452669681102533 -1.0481886964117115 down LAQANGWGVMVSHR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LAQANGWGVMVSHR 14 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 3009163700.0 504279100.0 1543615100.0 961269500.0 False True 652799235.7771525 1457711562.7382755 786328314.4579912 1.0 2.233016650215408 1.2045484604801557 29.282064127466583 -6.601614726269876 2.185056507087579 1.8283855102375772 1.2079705487964596 0.025059434825504545 0.5327354264792246 0.6361558993828309 5.7428104150487655 0.20222713924456975 0.5922681300642022 2.5025644661114554e-07 6.601614726269876 -0.6204149614411176 LAQAWFNTHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAQAWFNTHR 10 0 Q96A33;Q96A33-2 Q96A33 CCDC47 Coiled-coil domain-containing protein 47 0 20276300.0 7159500.0 4931800.0 8185000.0 False True 9386173.83269662 4195994.664005834 7338094.716064034 1.0 0.4470399482043618 0.7817982968205716 23.16210574876632 -10.364681447138464 6.124210291952635 1.000049578235634 0.6144191225124781 0.638847660893938 0.136664523541074 9.252398441367336e-05 9.59836942933286e-06 0.13234180464483566 0.04410828530766251 4.318357100536192e-11 10.364681447138464 -0.3856304557231559 LAQAWFNTHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAQAWFNTHR 10 0 Q96A33;Q96A33-2 Q96A33 CCDC47 Coiled-coil domain-containing protein 47 0 14833100.0 7159500.0 3310000.0 4363600.0 False True 9806560.628212558 3163753.2552937386 3333007.551162969 1.0 0.32261598895253 0.33987528120452526 23.22531581028921 -9.90558546403691 7.008280505694972 1.0000000142989403 0.3312456351541663 0.9995007048288888 0.007046076556505311 1.5804971180989697e-09 2.4659858449976383e-10 0.006822334493177567 0.002274111429952177 1.242838035896645e-10 9.90558546403691 -0.668754379144774 LAQDKEEMK(ub)VK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAQDKEEMKVK 11 2 Q08379;Q08379-2;A0A087WYC0 Q08379 GOLGA2 Golgin subfamily A member 2 1 3304950.0 978950.0 1024000.0 1302000.0 True False 1267270.0729894298 967013.4998316576 1065049.3596481578 1.0 0.7630682049884748 0.8404280842328716 20.273292585074767 -10.423531132339424 8.321236139742297 1.000003164343966 0.8017481446106732 0.8975065843103281 0.03158203845201587 1.8540584118201195e-06 1.2841470844920635e-07 0.030579665152194686 0.01019305908032831 3.771107109136737e-11 10.423531132339424 -0.19825501973329274 LAQEEESEAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAQEEESEAKR 11 1 B5MCF9;O00541-2;O00541;B3KXD6;H7C267 B5MCF9 PES1 Pescadillo homolog 1 12553000.0 3488200.0 5576400.0 3488400.0 True False 4573063.979776851 4744422.8566369545 3127453.831095634 1.0 1.0374713491037721 0.6838858684081307 22.12472967273782 -6.8806969829747056 1.0758693934365384 1.0234470236450561 0.6584866062904788 0.9742447770796203 0.025451089485904504 0.12701609111236498 0.268551530838748 0.018210961159575517 0.04411907826949273 1.316142814342124e-07 6.8806969829747056 -0.3649604173545773 LAQEEESEAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAQEEESEAKR 11 1 B5MCF9;O00541-2;O00541;B3KXD6;H7C267 B5MCF9 PES1 Pescadillo homolog 1 12811800.0 4878500.0 4475400.0 3457900.0 True False 4723634.687855892 6262450.558902686 2552172.255223605 1.0 1.3257694493189691 0.5402983981350309 22.171465964542353 -6.794067363884849 1.4800497836424016 1.1811134778386683 0.530983333968612 0.8142369733787033 0.13887642663656447 0.22933773976025248 0.9923139156353886 0.07384096773525266 0.17238135278322853 1.6066920179544084e-07 6.794067363884849 -0.6501301438700563 LAQEEESEAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAQEEESEAKR 11 1 B5MCF9;O00541-2;O00541;B3KXD6;H7C267 B5MCF9 PES1 Pescadillo homolog 1 20864900.0 5588200.0 5566400.0 9710300.0 True False 8477707.952143379 4573032.429518296 7791054.948824315 1.0 0.5394184908625118 0.9190048764129154 23.01524283729165 -9.999078083987747 7.0199229954106075 1.000000025482096 0.7292116836377136 0.4042452019933118 0.15496549298431012 6.171488941419541e-08 8.917980417179537e-09 0.1500447068062793 0.05001489779708781 1.0021250447807853e-10 9.999078083987747 -0.2707883418443824 LAQEEESEAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAQEEESEAKR 11 1 B5MCF9;O00541-2;O00541;B3KXD6;H7C267 B5MCF9 PES1 Pescadillo homolog 1 12141600.0 3488200.0 4485300.0 4168100.0 True False 4777881.805060557 4287124.615096374 3183680.6247140807 1.0 0.897285615260639 0.6663372503987108 22.187939734260713 -6.957692159464668 0.46682671389812247 1.0062919110770858 0.547913687199154 0.9996747825556774 0.002516252121035996 0.08053612444959134 0.024257549076151446 0.003174525296000486 0.019066112423430766 1.1023203893724678e-07 6.957692159464668 -0.4583782238779318 LAQEEESEAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAQEEESEAKR 11 1 B5MCF9;O00541-2;O00541;B3KXD6;H7C267 B5MCF9 PES1 Pescadillo homolog 1 12791800.0 4878500.0 6162900.0 1750400.0 True False 4056688.904194406 6129699.234460121 2116400.547064824 1.0 1.5110104272778546 0.5217063957940121 21.95187123997663 -6.766307185433184 1.5885287348721469 1.2944807509778447 0.5168935825845729 0.7162627885002307 0.21517482037208707 0.272441115528357 1.3561697867504188 0.10680518644331516 0.2551179362165735 1.7127454188460506e-07 6.766307185433184 -0.7775871683932718 LAQEEESEAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAQEEESEAKR 11 1 B5MCF9;O00541-2;O00541;B3KXD6;H7C267 B5MCF9 PES1 Pescadillo homolog 1 25238400.0 5588200.0 6994200.0 12656000.0 True False 7234035.059890216 6604966.621604069 10352737.861526184 1.0 0.9130404493373172 1.4311152456155358 22.7863691593841 -6.863732344313961 1.1666587537903135 0.952260704729643 1.4580606648906667 0.958021998558853 0.04641173271196379 0.14301049496576787 0.3677659423172882 0.030976117028207337 0.07264286373721444 1.3685720166637539e-07 6.863732344313961 0.5057999601610237 LAQEEESEAKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAQEEESEAKR 11 1 B5MCF9;O00541-2;O00541;B3KXD6;H7C267 B5MCF9 PES1 Pescadillo homolog 0 1433280.0 418020.0 172500.0 842760.0 False True 404750.1839125797 241380.149575616 622015.8737419369 1.0 0.5963682270438465 1.5367896012526172 18.626672210504385 -6.790073266838025 1.4960756888348852 0.7744336513892739 1.5468071809415056 0.8015576115261941 0.1715972967251039 0.23523861945381352 1.0401652215108952 0.09028135681843974 0.21135626440094685 1.6215365159984498e-07 6.790073266838025 0.7723735295522317 LAQGLTHLGK(ub)GTLTLCPYHSDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAQGLTHLGKGTLTLCPYHSDR 22 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 75291100.0 7761100.0 35825000.0 31705000.0 True False 11774156.112411862 29431748.847997416 25438492.853204846 1.0 2.4996907266221484 2.1605363994102786 23.489120325657467 -10.464803425611148 5.6341823710613435 0.9987162150769413 2.330113563016166 0.953505483042052 0.13845917428767454 0.0022343202003857945 0.00021224034995357059 0.1341543710423952 0.04468750634548182 3.4292296839242004e-11 10.464803425611148 1.3313973479392247 LAQGLTHLGK(ub)GTLTLCPYHSDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAQGLTHLGKGTLTLCPYHSDR 22 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 71668100.0 7761100.0 34849000.0 29058000.0 True False 10046896.94415267 32909622.515266974 23769742.16025818 1.0 3.275600685286266 2.365878966648728 23.260246647749916 -10.466411229969635 6.166261790108275 0.9990667540690302 2.8207398259674368 0.8422945821948098 0.3713923364316227 0.0047665293630724855 0.0004124638977743408 0.3597197737839205 0.11986636115906128 3.41655778177923e-11 10.466411229969635 1.8216730718984064 LAQHITYVHQHSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAQHITYVHQHSR 13 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 16902800.0 3565600.0 5646900.0 7690300.0 False True 4674536.129319519 4804404.531443805 6894581.526566552 1.0 1.027782093994253 1.4749231444212219 22.15639177771825 -6.919586672419235 0.8277696997052153 0.9899868768021411 1.5463517086805276 0.9940658280580286 0.016764690550937607 0.09841521616090593 0.10687287691529117 0.01441306840219924 0.04300596066969 1.2034092007037643e-07 6.919586672419235 0.5563648318783865 LAQHITYVHQHSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAQHITYVHQHSR 13 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 9566000.0 2364900.0 1178600.0 6022500.0 False True 2289827.543980811 1649221.1263178051 4445026.578872769 1.0 0.7202381378689652 1.9412058303505233 21.126807516636553 -6.846455329196864 1.2522425089374465 0.8510567024380924 1.9867327031174897 0.9349615962684399 0.1331926742551305 0.16140168972562352 0.4888568648429428 0.0833041494755255 0.1923652947299972 1.4241137210655745e-07 6.846455329196864 1.1356760006793973 LAQHITYVHQHSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAQHITYVHQHSR 13 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 14736200.0 3565600.0 5105600.0 6065000.0 False True 4883898.676716912 4880017.710038582 4632571.912595886 1.0 0.9992053547923032 0.9485397259940752 22.219601839241143 -6.9103080864775315 0.8936141979067352 1.0015534741513723 0.9419482697213105 0.9910376958870166 0.002279016927835128 0.10421520188632268 0.13765747755861438 0.0018687077396921338 0.005169688610156597 1.229396333379194e-07 6.9103080864775315 -0.05960520443006179 LAQHITYVHQHSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAQHITYVHQHSR 13 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 6805500.0 2364900.0 2505000.0 1935600.0 False True 1966519.1328337276 2491505.067796432 2340325.0107967756 1.0 1.2669620275731601 1.1900850450533877 20.90721279207083 -10.09808465121437 4.300962292642843 0.9999751134380671 1.228523536219132 0.9217631406867108 0.03138489692723203 10921228.778986514 0.23014656238847025 3264.901583116425 0.01074388497064519 7.97839159995234e-11 10.09808465121437 0.2285484227810649 LAQHITYVHQHSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAQHITYVHQHSR 13 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 18829060.0 2518000.0 8790260.0 7520800.0 False True 3259600.6372004524 8301074.303740454 6152091.569924636 1.0 2.5466537860508986 1.8873758643047862 21.63626378714735 -10.519769075145131 5.860920328221033 0.9981349062007816 2.2170148251778428 0.8196095300409503 0.2691490844934198 0.006565221682557741 0.0005379390332335719 0.2608355359132178 0.08686749349083216 3.021557928590407e-11 10.519769075145131 1.2188799189770612 LAQK(ub)KPFTPVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAQKKPFTPVK 11 2 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 1 7991500.0 1782700.0 2023200.0 4185600.0 True False 2337136.96369136 1721346.4463718326 3752514.2631102744 1.0 0.7365192853965541 1.6056030610989165 21.156310852460013 -6.82537323078501 1.3483838194149407 0.8587008918685193 1.6268663305167474 0.8963114601629764 0.11716238087746059 0.1865928110575634 0.6650787587827718 0.06825224916370295 0.15713786027985455 1.494950350064772e-07 6.82537323078501 0.7681654386482282 LAQK(ub)KPFTPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAQKKPFTPVK 11 2 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 1 12954300.0 1236300.0 2224000.0 9494000.0 True False 1197054.3332164055 3112054.798006784 7007236.58610512 1.0 2.599760688927878 5.8537331110753685 20.191057205718284 -6.959713399166554 0.43945417060776604 0.8829874489772334 7.6972591358753055 0.9997594222044834 0.031323969255273185 0.07980366127263669 0.021510789452846863 0.04287277925521122 0.2696400181492974 1.0972020259215256e-07 6.959713399166554 6.814271686898072 LAQK(ub)KPFTPVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAQKKPFTPVK 11 2 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 1 66240500.0 4490500.0 10807000.0 50943000.0 True False 6812416.799523973 8878406.414523598 40874093.72088995 1.0 1.3032682344309863 5.9999402449577195 22.69973527448317 -6.920040338460497 0.8244320941248926 0.8965220459455452 6.758012890803689 0.9941920352293081 0.17443436567008067 0.09814798416026776 0.10549276659963314 0.15032513890121843 0.45046592432067534 1.202152770191077e-07 6.920040338460497 5.861490844858144 up LAQK(ub)KPFTPVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAQKKPFTPVK 11 2 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 1 9102100.0 1782700.0 1568900.0 5750500.0 True False 2441812.3656560592 1499580.8103414953 4392350.335265064 1.0 0.6141261431193515 1.798807474744252 21.219520913982905 -6.818979053536372 1.3761776039477511 0.7917934443506693 1.8241320353698562 0.8820412383004718 0.16943834335207555 0.19481150593999805 0.7252184349887272 0.09675708541042663 0.2230842817720499 1.5171235381027467e-07 6.818979053536372 1.032338591019187 LAQK(ub)KPFTPVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAQKKPFTPVK 11 2 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 1 11100200.0 1236300.0 3371100.0 6492800.0 True False 1028038.2273763533 3352939.215189043 7850414.4606846925 1.0 3.2614927401542717 7.6363059773756286 19.97146248115256 -6.960691097946812 0.4255827347035725 0.8178610883095159 10.24648716849016 0.9997949762141506 0.03944317019439211 0.07945517617093174 0.020226005576271352 0.05682267453430706 0.3636330730778718 1.0947347449733282e-07 6.960691097946812 9.428626080180646 LAQK(ub)KPFTPVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAQKKPFTPVK 11 2 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 1 54605500.0 4490500.0 10120000.0 39995000.0 True False 5813040.77098834 9556813.10380504 32716320.383354954 1.0 1.6440299458247527 5.6280906451981565 22.47086159657562 -6.935191418306123 0.7028708168903955 0.9494763519257424 6.565792309362774 0.9974638404444486 0.10308049803693445 0.0900302973404205 0.06512126879906593 0.0970030767274485 0.35077144691380147 1.1609368101042342e-07 6.935191418306123 5.616315957437031 LAQK(ub)NPMYQK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LAQKNPMYQK 10 1 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 34920700.0 14993900.0 14828900.0 5097900.0 True False 19657148.10113414 12616485.922599481 4570418.210509809 1.0 0.641826874259118 0.2325066783337769 24.228550691953068 -7.431561534457069 0.36218058528684016 1.0497672611599322 4.965323008481604e-13 0.999444837683762 0.0073880539491539025 0.11646829967503425 0.03640879307632758 0.016956020903700422 0.06105483738308194 3.702017484188421e-08 7.431561534457069 -1.0497672611594357 down LAQK(ub)NPMYQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAQKNPMYQK 10 1 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 26757990.0 10412600.0 11864400.0 4480990.0 True False 10082057.712569073 16601916.79202865 3307284.2921815016 1.0 1.6466794046746447 0.32803663562234775 23.26528678209229 -6.773327433723293 1.5614994628055232 1.3693301923975816 0.31962740366834314 0.7432231730934988 0.27280734318170125 0.2610704567914303 1.2566761619478233 0.1376669327465285 0.32674366615383355 1.685281938061917e-07 6.773327433723293 -1.0497027887292385 LAQK(ub)NPMYQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAQKNPMYQK 10 1 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 23167200.0 3388800.0 13333800.0 6444600.0 True False 5141057.354465392 10954279.212545093 5170821.985231473 1.0 2.1307444086439697 1.0057895932128103 22.29363367644086 -6.644970722417442 2.0263521426498308 1.7366261674819417 1.010485227646132 0.17400456813655563 0.48321237925117577 0.520938845607265 4.093979376743611 0.1937791525287827 0.5351797249153852 2.2647969817539868e-07 6.644970722417442 -0.7261409398358096 LAQK(ub)NPMYQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAQKNPMYQK 10 1 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 21625730.0 10413800.0 7554300.0 3657630.0 True False 14264063.282363301 7220526.047270528 2793773.1252544224 1.0 0.5062040110406897 0.1958609598086096 23.76588167280231 -8.421326500261546 0.277107159020283 1.1919764718951358 7.454519579810604e-19 0.999113427101184 0.009859334035623892 0.13644397027365843 0.07121653472729554 0.11420338420369126 0.10204963043293358 3.790299251696092e-09 8.421326500261546 -1.1919764718951358 down LAQK(ub)NPMYQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAQKNPMYQK 10 1 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 29986410.0 10412600.0 16824800.0 2749010.0 True False 8658538.256393284 16734161.462938681 3323815.281013866 1.0 1.9326774297708422 0.38387718372204804 23.045692057526566 -6.743611216197566 1.673140779583952 1.5525891930294387 0.3821717424060825 0.6212010531487283 0.3918564614244641 0.3113122571182891 1.7124261493087638 0.1851656412564468 0.452649991275336 1.804632539064999e-07 6.743611216197566 -1.1704174506233562 LAQK(ub)NPMYQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAQKNPMYQK 10 1 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 29778800.0 3388800.0 21484000.0 4906000.0 True False 4386868.403234671 20288396.5140462 4013158.3398109544 1.0 4.624801714837511 0.9148116539925929 22.064759998533308 -6.6515301503544855 2.003417332243446 3.3493848007363574 0.9305542781458244 0.20007807818796308 1.5465472475933257 0.5048441693606014 3.885788728072288 0.6257355879274586 1.712773513995915 2.2308473283035224e-07 6.6515301503544855 -2.418830522590533 LAQK(ub)YHPDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAQKYHPDK 9 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 6467100.0 1833900.0 2807100.0 1826100.0 True False 2404260.6595128602 2388291.621990099 1637152.6891880904 1.0 0.9933580256951021 0.6809381015783049 21.197161884591598 -6.9114910952093975 0.885522730135287 1.0092229239576116 0.639248824694939 0.9914721317810585 0.013747282601169579 0.10344013673921859 0.13348113712066037 0.011338730050286868 0.031632882116400605 1.2260520414379666e-07 6.9114910952093975 -0.36997409926267255 LAQK(ub)YHPDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAQKYHPDK 9 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 6286200.0 1784900.0 2960800.0 1540500.0 True False 1728239.326504864 4143062.8803680222 1136996.835990618 1.0 2.3972738131974003 0.6578931624533993 20.720871585004822 -6.692829214501847 1.85615981623751 1.8736517560916015 0.6636544245426134 0.3838118061210972 0.5906108201484805 0.4106041367372039 2.7448854127388786 0.25433000592318805 0.6599903551044894 2.028480258788736e-07 6.692829214501847 -1.2099973315489883 LAQK(ub)YHPDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAQKYHPDK 9 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 4806400.0 1833900.0 1617900.0 1354600.0 True False 2511942.3892840287 1546415.8283201628 1034671.3788627182 1.0 0.6156255155043318 0.41190091909616905 21.26037194611449 -10.88595086151217 0.11717150802510906 1.9691754329954714 2.4191724194725847e-20 0.9998319840104832 0.003160632805133473 3.0548284436476534 0.06815808409425357 1.0733100994564215 0.26660616834899165 1.3003166947573767e-11 10.88595086151217 -1.9691754329954714 LAQK(ub)YHPDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAQKYHPDK 9 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 4107300.0 1784900.0 1230100.0 1092300.0 True False 1484223.4344771127 1223473.2071442676 1320694.8797754268 1.0 0.8243187506167449 0.8898221447640082 20.5012768604391 -10.760467799812893 9.515462849301986 1.0007513845813885 0.8570704481603171 0.863913488882267 0.026741648680200878 0.0004283931000757094 1.0783906676578575e-05 0.026021590015589617 0.00863082999904562 1.735929966320113e-11 10.760467799812893 -0.14368093642107138 LAQK(ub)YHPDKNPEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAQKYHPDKNPEGR 14 2 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 18972300.0 5500000.0 8111300.0 5361000.0 True False 7210553.26207576 6901125.657599759 4806295.146343228 1.0 0.9570868429606574 0.666563989149371 22.781678530292343 -6.933336758366141 0.7188740192814629 1.003917918658873 0.6015150426237604 0.9971543725122813 0.00790075021711172 0.09094193849031854 0.0694609804318794 0.007346543862083789 0.025821985877777235 1.1659052063143771e-07 6.933336758366141 -0.4024028760351125 LAQK(ub)YHPDKNPEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAQKYHPDKNPEGR 14 2 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 33142000.0 11251000.0 10840000.0 11051000.0 True False 10893843.163486034 15168468.529853202 8156411.577106348 1.0 1.392389104764685 0.7487175512536288 23.377009666455745 -6.741671519527816 1.6802678139074396 1.23300673868099 0.7481753157022595 0.612606287303902 0.16486025461028297 0.3147736987310929 1.745540276861632 0.07759449626330192 0.19008440324094 1.812710625615069e-07 6.741671519527816 -0.4848314229787305 LAQK(ub)YHPDKNPEGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAQKYHPDKNPEGR 14 2 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 15988800.0 8937700.0 3512700.0 3538400.0 True False 13559144.333393933 2885831.2401496335 2839033.689064189 1.0 0.21283284322317506 0.20938147859906747 23.692762802499978 LAQK(ub)YHPDKNPEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAQKYHPDKNPEGR 14 2 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 20114600.0 5500000.0 8202600.0 6412000.0 True False 7533498.631911317 7840182.009629131 4897617.659285216 1.0 1.040709289627893 0.6501119730133469 22.844888591815234 -6.881165050960922 1.0732514053626239 1.0256432036702445 0.6218013869471614 0.974614324916726 0.02793409581597459 0.12660436331829417 0.26607670140108336 0.02002772313019693 0.048579919810936886 1.3147250840101768e-07 6.881165050960922 -0.40384181672308317 LAQK(ub)YHPDKNPEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAQKYHPDKNPEGR 14 2 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 27848070.0 11251000.0 12547000.0 4050070.0 True False 9355705.00381085 12479406.820615504 4896920.911592109 1.0 1.3338820340671578 0.5234154892226135 23.15741494189002 -6.794834670685634 1.476929147161989 1.1854396358211754 0.5136058496100614 0.8166244926462112 0.14241726169473676 0.228214643138856 0.983246446235624 0.07588016332403287 0.17705168849788877 1.6038558380511536e-07 6.794834670685634 -0.671833786211114 LAQK(ub)YHPDKNPEGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAQKYHPDKNPEGR 14 2 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 15588000.0 8937700.0 4059000.0 2591300.0 True False 11570028.838406084 3833113.081852237 2119709.9889833103 1.0 0.33129676126030266 0.183206975417991 23.463889124592427 -13.999999999999938 0.2118405865197996 4.8969061827710725 0.09752277149134923 0.9994911249471155 0.008015309408393248 12.790418648630075 0.14587049767225824 20.764207307189608 0.08660353958005207 1.0000000000001431e-14 13.999999999999938 -4.799383411279723 LAQMSICSSLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAQMSICSSLAR 12 0 O95861-4;O95861;O95861-2;A6NF51;F8VZG4;F8W1J0;F8VVW8 O95861-4 BPNT1 3(2),5-bisphosphate nucleotidase 1 0 29828100.0 6751100.0 11384000.0 11693000.0 False True 8850757.477745399 9685551.574484445 10483120.527176142 1.0 1.0943189437557268 1.1844320165291167 23.077369500522337 -6.971680064769603 0.2142992939155931 0.9553330197557615 1.325945808800054 0.9999926825477917 0.00020361218035321924 0.07576128005009154 0.007045922047682882 0.002608601707562111 0.00924721299790093 1.0673821487150977e-07 6.971680064769603 0.3706127890442925 LAQMSICSSLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAQMSICSSLAR 12 0 O95861-4;O95861;O95861-2;A6NF51;F8VZG4;F8W1J0;F8VVW8 O95861-4 BPNT1 3(2),5-bisphosphate nucleotidase 1 0 21152000.0 6751100.0 5443900.0 8957000.0 False True 9247164.111617548 5203370.497430088 6841541.075205498 1.0 0.5626990539610847 0.7398528881530524 23.14057956204523 -10.154033000051896 5.291851209841054 1.0000116345711934 0.6512759710569062 0.8378349987558473 0.0723227499585578 9.927690077006082e-06 1.587047753335898e-06 0.07002853647999366 0.023342067178369466 7.014020000641782e-11 10.154033000051896 -0.3487356635142872 LAQMSICSSLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAQMSICSSLAR 12 0 O95861-4;O95861;O95861-2;A6NF51;F8VZG4;F8W1J0;F8VVW8 O95861-4 BPNT1 3(2),5-bisphosphate nucleotidase 1 0 39175600.0 8866600.0 19094000.0 11215000.0 False True 11477988.486815538 18031402.11502503 9173985.075617578 1.0 1.5709548877607973 0.7992676666434622 23.452366496611177 -6.708527734057797 1.8005875699188867 1.351538017744397 0.8011680455189649 0.4580638313590113 0.24065318552287482 0.378032898776425 2.388255145318819 0.10639994455774601 0.27077593598045224 1.9564658239831163e-07 6.708527734057797 -0.550369972225432 LAQPYVGVFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAQPYVGVFLK 11 0 K7EJE8;K7EKE6;P36776-2;P36776;K7EQF8 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 41024000.0 11466000.0 14414000.0 15144000.0 False True 15032037.036901943 12263487.385331927 13577044.15150563 1.0 0.8158233880894824 0.9032072045974561 23.84153719069157 -10.052413078396027 4.37515765363507 1.0000098096546515 0.8595152963248317 0.7750865548173517 0.03567429376394948 24727963.85114974 2725.2871802337227 2501.337977330362 0.012212259626788796 8.863125964024007e-11 10.052413078396027 -0.14049451332981977 LAQPYVGVFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAQPYVGVFLK 11 0 K7EJE8;K7EKE6;P36776-2;P36776;K7EQF8 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 39064500.0 15466000.0 6759500.0 16839000.0 False True 14975040.295660386 9458603.600326836 12428360.740828313 1.0 0.6316245842134958 0.829938383833927 23.836056549313824 -10.16337136667178 4.99930185864223 1.000017682585085 0.7307814840232265 0.7107496281383672 0.0809612696721157 1.5957458687448456e-05 2.670551567738299e-06 0.0783955582288791 0.026130137427085375 6.864811766021673e-11 10.16337136667178 -0.26923619856185854 LAQQEK(ub)QEQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAQQEKQEQVK 11 1 B9A067;Q16891-2;Q16891-4;Q16891;C9J406;A0A087WYS0 B9A067 IMMT MICOS complex subunit MIC60 1 6182800.0 1967000.0 2481900.0 1733900.0 True False 2578756.048455093 2111610.194370428 1554492.6607432414 1.0 0.8188483728949362 0.602807179715399 21.298243869271488 -6.968787857894458 0.2856583806408773 1.044466201328001 0.37055470559050624 0.9999713221265449 0.0008694556671851456 0.07669800569009089 0.01043122204806101 0.0038648928875851256 0.019692138631318364 1.0745141577398742e-07 6.968787857894458 -0.6739114957374948 LAQQEK(ub)QEQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAQQEKQEQVK 11 1 B9A067;Q16891-2;Q16891-4;Q16891;C9J406;A0A087WYS0 B9A067 IMMT MICOS complex subunit MIC60 1 7556400.0 2509200.0 2846200.0 2201000.0 True False 2429546.8194666393 3982702.50273692 1624492.0714153515 1.0 1.6392779389249417 0.6686399530970873 21.212255804027365 -6.729081941278754 1.726779083407755 1.385109956288171 0.6693339373063968 0.5549330591039321 0.26875659037965877 0.3379525464122565 1.9737851601185583 0.12336582206260546 0.3064190556276615 1.8660275815671458e-07 6.729081941278754 -0.7157760189817742 LAQQEK(ub)QEQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAQQEKQEQVK 11 1 B9A067;Q16891-2;Q16891-4;Q16891;C9J406;A0A087WYS0 B9A067 IMMT MICOS complex subunit MIC60 1 6719100.0 1967000.0 2434100.0 2318000.0 True False 2694253.056176282 2326553.4135077004 1770536.1407085343 1.0 0.863524459283559 0.6571528745786417 21.36145393079438 -6.965122806058423 0.3559386236053265 1.0186288162767432 0.49502079108432406 0.9999156527227784 0.0012943265605846054 0.07791930956233908 0.014713154585671663 0.0027928576937100106 0.017670539684547733 1.0836204538219522e-07 6.965122806058423 -0.5236080251924191 LAQQEK(ub)QEQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAQQEKQEQVK 11 1 B9A067;Q16891-2;Q16891-4;Q16891;C9J406;A0A087WYS0 B9A067 IMMT MICOS complex subunit MIC60 1 7546000.0 2509200.0 3680700.0 1356100.0 True False 2086510.9764076252 3660871.3385382504 1639654.2401020376 1.0 1.7545420944016423 0.7858354250908629 20.99266107946164 -6.698842438678666 1.8347327398645639 1.46908147792836 0.7887604201756523 0.4120765652576803 0.31857209956294374 0.39800563755793256 2.603857229710704 0.1385552039521516 0.3568725117057768 2.0005875478482178e-07 6.698842438678666 -0.6803210577527078 LAQQMENRPSVQAALK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAQQMENRPSVQAALKLK 18 2 X6R700;Q9Y3Y2-4;Q9Y3Y2;Q9Y3Y2-3;A0A087X1B7;Q5T7Y7 X6R700 CHTOP Chromatin target of PRMT1 protein 1 11351300.0 2851500.0 5216000.0 3283800.0 True False 2371148.5928687826 5187900.372705061 3970427.3974242867 1.0 2.1879271456490095 1.674474307247267 21.177154644407977 -10.513574952223909 5.608296456750451 0.9982581003436851 1.9312007264477977 0.8143180003716114 0.2096162435113328 0.0045716760928229605 0.00039651541892554395 0.20323614242768226 0.06765335168449539 3.0649616708207694e-11 10.513574952223909 0.9329426261041126 LAQQYYLVYQEPIPTAQLVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAQQYYLVYQEPIPTAQLVQR 21 0 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 6944600.0 1346100.0 4278500.0 1320000.0 False True 1764750.1356509416 3640164.477462379 1183419.0623340881 1.0 2.062708144300369 0.6705873190923852 20.751032501503097 -6.702664907457734 1.8212107613607498 1.6581631924832945 0.6744937044391547 0.43029758701790466 0.4483669228108302 0.39000865829490483 2.5166829604456615 0.19626362782766255 0.5031135918203242 1.98305652061685e-07 6.702664907457734 -0.9836694880441398 LAQQYYLVYQEPIPTAQLVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAQQYYLVYQEPIPTAQLVQR 21 0 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 26604500.0 9913500.0 5726000.0 10965000.0 False True 9598801.368875545 8012421.660695528 8092937.557051045 1.0 0.8347314787319269 0.8431195985878699 23.194422832747186 -10.433019618567577 5.426869420792534 1.000134926791603 0.8389255386598972 0.9979701873956427 0.0034244355913988435 5.5950117307684255e-06 5.845422710472639e-07 0.0033184635746804155 0.0011052318346367073 3.689609309661276e-11 10.433019618567577 -0.16120938813170593 LAQQYYLVYQEPIPTAQLVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAQQYYLVYQEPIPTAQLVQR 21 0 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 11922200.0 1346100.0 2481400.0 8094700.0 False True 1843789.5469846947 2371763.543107518 6182898.575579541 1.0 1.2863526355197445 3.353364588540465 20.81424256302599 -6.932061471088401 0.7296782165129612 0.9708460363345385 3.80087375034036 0.9969280068297103 0.05810985911211322 0.09158161612052106 0.07254088698267336 0.0536053269670157 0.18495470305251754 1.1693338689699356e-07 6.932061471088401 2.8300277140058214 up LAQSHHVK(ub)QVLVAPGNAGTACSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAQSHHVKQVLVAPGNAGTACSEK 24 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 21146500.0 3874400.0 4731100.0 12541000.0 True False 5877748.056580712 3886798.240746981 10062265.85308444 1.0 0.661273365808072 1.7119253421927045 22.486832090050147 -6.819928508966288 1.372168797250169 0.817414034987337 1.7348295213690956 0.8842196661745337 0.14898634031081898 0.1935762072647529 0.7161896437854045 0.08532291416712123 0.19666074694376118 1.5138104226011163e-07 6.819928508966288 0.9174154863817586 LAQSNGWGVMVSHR ddPTM_RPMI8226_Bortezomib_1h_R1 2 LAQSNGWGVMVSHR 14 0 P13929;P13929-3;P13929-2 P13929 ENO3 Beta-enolase 0 279019100.0 230421300.0 26731900.0 21865900.0 False True 302084555.7030437 22743604.7201301 19603426.420523483 1.0 0.07528886959215354 0.06489383866348374 28.170377186196212 LAQSNGWGVMVSHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAQSNGWGVMVSHR 14 0 P13929;P13929-3;P13929-2 P13929 ENO3 Beta-enolase 0 437601490.0 178681700.0 5608390.0 253311400.0 False True 173009547.23891756 7847849.374367473 186961545.16089162 1.0 0.045360787884902005 1.080642936442733 27.366276411840627 -12.18657280608058 15.46869049257617 0.9408937750906041 0.606701675947437 0.0 0.4811124202350424 0.0 0.0 0.0 0.14004116608473993 6.507695052664785e-13 12.18657280608058 -0.33419209914316717 LAQSNGWGVMVSHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAQSNGWGVMVSHR 14 0 P13929;P13929-3;P13929-2 P13929 ENO3 Beta-enolase 0 172601800.0 148926900.0 8712600.0 14962300.0 False True 225932995.3147814 7157768.458145498 12004994.846790934 1.0 0.031680934642471896 0.05313519979702372 27.75131973678395 -10.653081609766984 3.0364370831626593 1.0846780993401193 0.04240806600342429 0.9996236735902421 0.008758670925019531 8962393.895900141 9299273.83821032 5935202.096505834 0.003425626937351379 2.2228921401091495e-11 10.653081609766984 -1.042270033336695 LAQSNGWGVMVSHR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LAQSNGWGVMVSHR 14 0 P13929;P13929-3;P13929-2 P13929 ENO3 Beta-enolase 0 453956700.0 230421300.0 25028200.0 198507200.0 False True 315614281.5114964 23922371.366810463 151623887.74411443 1.0 0.07579622586229222 0.48040883010102775 28.233587247719104 -10.71290966118712 6.578021192475696 1.0093323106506404 0.2781025300070967 0.8093185194475336 0.16518240398059536 0.022450415597115393 0.0009798218993973312 0.15882677845133708 0.05331239164194595 1.9368248064055148e-11 10.71290966118712 -0.7312297806435437 LAQSNGWGVMVSHR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LAQSNGWGVMVSHR 14 0 P13929;P13929-3;P13929-2 P13929 ENO3 Beta-enolase 0 419431310.0 199393950.0 128035660.0 92001700.0 False True 165804904.07471442 127345906.48649123 111238830.10220172 1.0 0.7680466823171109 0.6709019297286627 27.304911437703602 -13.999999999999991 0.1192620261935767 2.106154246276571 0.51430005220084 0.9996965693413065 0.0024048956480441854 11.966665458339898 0.10618691556690134 3.1404559712263285 0.13896122775089165 1.0000000000000205e-14 13.999999999999991 -1.5918541940757311 LAQSNGWGVMVSHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAQSNGWGVMVSHR 14 0 P13929;P13929-3;P13929-2 P13929 ENO3 Beta-enolase 0 514205000.0 148926900.0 352466100.0 12812000.0 False True 192788807.83808094 332851051.69239706 10480347.462221367 1.0 1.7265060945444057 0.05436180440009557 27.5224460588764 -6.788602146275794 1.5018737195381298 1.4067644377190653 0.03723136422973005 0.7968272409556637 0.3085818619748255 0.2374099818990463 1.0579314150049315 0.16173877837917705 0.37906573162008134 1.6270385903585394e-07 6.788602146275794 -1.3695330734893354 LAQTLSTQLFQMVHTQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAQTLSTQLFQMVHTQR 17 0 P53367;P53367-2 P53367 ARFIP1 Arfaptin-1 0 7414000.0 2068000.0 2589700.0 2756300.0 False True 2711168.026540486 2203326.854571538 2471104.5162965553 1.0 0.8126854672976631 0.9114538428109683 21.370483097307893 -10.188522913517053 4.657597320292719 1.0000211288996974 0.8620696551165845 0.7222449500740434 0.04032202047199558 9788319.855482707 21412011.195206255 1488.7424919832883 0.013803298585128607 6.478539133854705e-11 10.188522913517053 -0.1379514737831129 LAQTLSTQLFQMVHTQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAQTLSTQLFQMVHTQR 17 0 P53367;P53367-2 P53367 ARFIP1 Arfaptin-1 0 17941900.0 5085300.0 3484600.0 9372000.0 False True 4923869.935052487 4876018.951948941 6917192.046026655 1.0 0.9902818344646148 1.4048283438162994 22.231361222589868 -6.901533256456087 0.951526261439351 0.9834818531194938 1.4497222352088517 0.9873135069970925 0.021757489121880004 0.11028596447499939 0.1711249009239736 0.017098796643138323 0.04484021323366948 1.2544886706811542e-07 6.901533256456087 0.4662403820893579 LAQTLSTQLFQMVHTQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAQTLSTQLFQMVHTQR 17 0 P53367;P53367-2 P53367 ARFIP1 Arfaptin-1 0 12084300.0 2068000.0 4705400.0 5310900.0 False True 2832595.4855986554 4497499.869323008 4056574.8014188767 1.0 1.5877663761694807 1.43210522718232 21.433693158830785 -10.034550099323809 4.542946280350614 0.9999804620055437 1.5099358015032551 0.9346789459106097 0.06354839809001726 9899558.988215227 10933171.637477737 1661.5997801959663 0.021754308193722503 9.235276460127793e-11 10.034550099323809 0.5099553394977114 LAQTLSTQLFQMVHTQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAQTLSTQLFQMVHTQR 17 0 P53367;P53367-2 P53367 ARFIP1 Arfaptin-1 0 10093200.0 5085300.0 1989700.0 3018200.0 False True 4228652.266987764 1978981.091175473 3649291.665419938 1.0 0.4679933383562842 0.8629916661412957 22.011766498024144 -9.897813259339774 6.037393607263001 1.0000000741430886 0.6654925022486563 0.488811267281532 0.16125739205479142 1.6090138269635113e-07 2.9673365758958945e-08 0.15613683336918094 0.052045599490017594 1.2652802836578723e-10 9.897813259339774 -0.33450757189443225 LAQYEPPQEEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAQYEPPQEEKR 12 1 Q99417;A0A087WV05 Q99417 MYCBP C-Myc-binding protein 1 10109100.0 2347100.0 3902500.0 3859500.0 True False 3560722.2959943716 3206068.3846283327 3096668.133321057 1.0 0.9003983231815056 0.8696741492041231 21.76373849229991 -13.999999991538475 0.16471267011736226 1.4957244239170235 0.8409880180274311 0.9995247630917026 0.0012126515302181276 12.044434082015194 0.1283975472572232 1.9071934004924647 0.026308300932733366 1.0000000194833811e-14 13.999999991538475 -0.6547364058895925 LAQYEPPQEEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAQYEPPQEEKR 12 1 Q99417;A0A087WV05 Q99417 MYCBP C-Myc-binding protein 1 8996400.0 2347100.0 4739400.0 1909900.0 True False 3038367.2182578193 4475648.223732576 1562317.7972288933 1.0 1.4730438759469253 0.5141965025954686 21.53486481439236 -6.772566953332538 1.5647366037691561 1.2704335627364867 0.5082854334350815 0.7402553934448235 0.19950782961728966 0.2622926568310558 1.2677577275369893 0.10048192088547833 0.23861926794110125 1.6882355713281986e-07 6.772566953332538 -0.7621481293014052 LASALAPSIYEHEDIK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 LASALAPSIYEHEDIKK 17 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 44268600.0 13775200.0 23118000.0 7375400.0 True False 18059420.59922657 19668884.51325821 6612264.357832459 1.0 1.0891204623752198 0.36613934104373436 24.10624827175725 -6.876044364956755 1.1016713797800446 1.0528060174640732 0.31864479872410834 0.9703499693125365 0.05542400693992975 0.13118929195731938 0.2939789863354529 0.038883447863413925 0.09315119341852952 1.330318513562011e-07 6.876044364956755 -0.7341612187399649 down LASALAPSIYEHEDIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 LASALAPSIYEHEDIKK 17 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 52119000.0 20783000.0 11036000.0 20300000.0 True False 20123255.041039042 15442732.3519797 14982821.013053901 1.0 0.767407276829024 0.7445525578490249 24.26236035164825 -13.999999999999998 0.32802705260223086 3.502049007780448 0.740410909570362 0.9997107298569337 0.001962877421483336 18.65802354381369 0.18304229326654334 32.17410444414742 0.007378235119514444 1.0000000000000041e-14 13.999999999999998 -2.761638098210086 LASALAPSIYEHEDIK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 LASALAPSIYEHEDIKK 17 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 150772000.0 56039000.0 26306000.0 68427000.0 True False 85015259.99967133 21611488.77028387 54902373.45738046 1.0 0.25420717139919846 0.6457943368942554 26.341218488401513 -10.730966988894432 6.773181249207742 1.0082823341436733 0.4500007541511659 0.7245410120433219 0.1598647908809468 0.019961769591411965 0.0007928870534897683 0.15453874102204213 0.05159613939390318 1.857945673809438e-11 10.730966988894432 -0.5582815799925074 LASALAPSIYEHEDIK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LASALAPSIYEHEDIKK 17 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 27181600.0 13775200.0 9786700.0 3619700.0 True False 18868263.70078271 9354291.233710935 2764801.4100615545 1.0 0.4957685233815602 0.1465318406561629 24.16945833328014 -8.214759181895195 0.339984492042989 1.1116337076969292 3.994830057983692e-17 0.9983837103020663 0.014084630515596868 0.09715002716454815 0.08143785530398878 0.07367160895848561 0.08922486701520665 6.098749817224511e-09 8.214759181895195 -1.1116337076969292 LASALAPSIYEHEDIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LASALAPSIYEHEDIKK 17 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 55004900.0 20783000.0 13560000.0 20661900.0 True False 17281985.343009595 13486949.588550732 24982207.760168385 1.0 0.7804051051348727 1.4455635312914705 24.042765627082527 -6.817735193995967 1.3815556794764696 0.8813586497726859 1.459400735967162 0.8791048241495585 0.09621681666645879 0.19644800445455518 0.7373653404859365 0.05473488534232574 0.12624310084755594 1.5214749485983523e-07 6.817735193995967 0.5780420861944761 LASALAPSIYEHEDIK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LASALAPSIYEHEDIKK 17 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 172649000.0 56039000.0 29258000.0 87352000.0 True False 72543590.19383492 27629766.58015099 71454832.30720879 1.0 0.3808712321285016 0.9849916735066877 26.112344810493962 -10.894601370657341 11.041524349670608 1.021746613225725 0.6829314530042829 0.2686212372614729 0.24663113742691883 0.10807668596615834 0.0010316611770659434 0.1954766461989582 0.0795998573258874 1.2746725380821227e-11 10.894601370657341 -0.338815160221442 LASDAGIFFTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LASDAGIFFTR 11 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9;G5E9J1 Q9NR46 SH3GLB2 Endophilin-B2 0 12068000.0 3469900.0 4237600.0 4360500.0 False True 4549072.502559396 3605366.598035428 3909317.2888695407 1.0 0.7925498210914377 0.8593657908661783 22.117140997633527 -10.243473158503445 7.44440880932359 1.000000406218283 0.825957805978808 0.9004642255836357 0.027277505436222982 1.839006494067833e-07 1.871481249415066e-08 0.026411392857819214 0.008803777023381159 5.7085635676159425e-11 10.243473158503445 -0.17404260023947504 LASDAGIFFTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LASDAGIFFTR 11 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9;G5E9J1 Q9NR46 SH3GLB2 Endophilin-B2 0 8694680.0 3496300.0 928680.0 4269700.0 False True 3385311.8702778607 1299506.7670022212 3151337.481745628 1.0 0.383866189231056 0.9308854257752541 21.690857316854924 -10.463420723597613 8.846034435564423 1.0000061407196232 0.6573758075031615 0.34343643468582885 0.22331966817001642 2.7045975328527515e-05 1.6405823918254859e-06 0.2162322117101536 0.07207611297525333 3.4401650264974276e-11 10.463420723597613 -0.34263033321646175 LASDLLEWIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LASDLLEWIR 10 0 O43707;O43707-2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;K7EJH8;G3V2W4 O43707 ACTN4;ACTN1 Alpha-actinin-4;Alpha-actinin-1 0 4809300.0 726900.0 2445300.0 1637100.0 False True 952972.9393096132 2080470.7717047443 1467708.5961720755 1.0 2.183137302106347 1.5401366981473426 19.8620757222781 -10.274278933089631 5.467167085418074 0.9999071705003086 1.8616370001268816 0.7053817887947312 0.2625038973336245 0.0002970514598861124 3.943134889019325e-05 0.2541953346712815 0.08472276855728703 5.317666133245163e-11 10.274278933089631 0.861729829626573 LASDLLEWIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LASDLLEWIR 10 0 O43707;O43707-2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;K7EJH8;G3V2W4 O43707 ACTN4;ACTN1 Alpha-actinin-4;Alpha-actinin-1 0 8371300.0 4025200.0 1748500.0 2597600.0 False True 3897422.2292830865 2446685.1683070427 1917210.6336703855 1.0 0.6277701065909658 0.49191761140620577 21.894088804422463 -13.999999999999998 0.14016838285281394 2.7783443006826265 0.3241336044673423 0.9996022628546645 0.0042833494077403975 11.934184722704845 0.11731245983416358 5.804297966886785 0.15001389430030357 1.0000000000000041e-14 13.999999999999998 -2.4542106962152843 LASDLLEWIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LASDLLEWIR 10 0 O43707;O43707-2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;K7EJH8;G3V2W4 O43707 ACTN4;ACTN1 Alpha-actinin-4;Alpha-actinin-1 0 11664000.0 726900.0 4246400.0 6690700.0 False True 995654.5737338797 4058780.0070330235 5110494.459291887 1.0 4.076494111619339 5.132798657396444 19.92528578380099 -9.255223485668527 0.36149917302179885 1.6070866442629898e-23 5.382292528355142 0.9981692204651585 0.07501147824608556 0.6492174557652999 0.13908874346750708 1.1893739677936213 0.29618979022140385 5.556182654388935e-10 9.255223485668527 5.382292528355142 LASDLLEWIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LASDLLEWIR 10 0 O43707;O43707-2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;K7EJH8;G3V2W4 O43707 ACTN4;ACTN1 Alpha-actinin-4;Alpha-actinin-1 0 7676100.0 4025200.0 1775300.0 1875600.0 False True 3347132.1465949216 1765736.1065305383 2267779.2882054327 1.0 0.5275370165252792 0.6775290573790079 21.67449407985674 -10.923401725964636 11.425066118292069 1.0529859458216198 0.6025330369521436 0.9035007093633236 0.061233994261720666 0.03184883923106002 0.00021352717549325638 0.022848505133211794 0.019763186666450383 1.1928841663105261e-11 10.923401725964636 -0.4504529088694762 LASDLLEWIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LASDLLEWIR 10 0 O43707;O43707-2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;K7EJH8;G3V2W4 O43707 ACTN4;ACTN1 Alpha-actinin-4;Alpha-actinin-1 0 6359230.0 679930.0 2730700.0 2948600.0 False True 880182.7884240279 2578734.1445217836 2411985.055190904 1.0 2.9297711548518475 2.740322904415771 19.747443635196674 -9.954779398591686 6.136298350536706 0.9999992923190895 2.8350470296340218 0.9920696885116825 0.07734192437265562 7.489121786480657e-07 1.2747722808903344e-07 0.07488602526979972 0.024961998754799555 1.1097383676248454e-10 9.954779398591686 1.8350477373149323 LASEK(ub)SEMQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LASEKSEMQR 10 1 Q08117;K7ELE3;Q08117-2 Q08117 AES Amino-terminal enhancer of split 1 5966900.0 1168900.0 1509100.0 3288900.0 True False 1532439.2196437009 1283948.1624257283 2948596.1773565086 1.0 0.8378460600377039 1.9241194949592002 20.54739842349632 -6.868901878413009 1.139819754213384 0.9088639822581748 1.9864420165085668 0.9635784890035801 0.09131054246495487 0.13791580722864155 0.33555828764515094 0.06220938263333909 0.14701650601610344 1.3523780759265103e-07 6.868901878413009 1.077578034250392 LASEK(ub)SEMQR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LASEKSEMQR 10 1 Q08117;K7ELE3;Q08117-2 Q08117 AES Amino-terminal enhancer of split 1 11643700.0 1762790.0 1840680.0 8040230.0 True False 1706831.1963524623 2575673.123019396 5934252.56127027 1.0 1.5090379930503197 3.4767659355839666 20.702888953860114 -6.945660481349931 0.6046127488114375 0.9780419542861674 4.109291718746101 0.9988152255416411 0.03676083921746713 0.08527650704950256 0.043544806782962735 0.03755963911348322 0.16561607602823175 1.1332859866591469e-07 6.945660481349931 3.131249764459933 LASEK(ub)SEMQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LASEKSEMQR 10 1 Q08117;K7ELE3;Q08117-2 Q08117 AES Amino-terminal enhancer of split 1 36082450.0 2456150.0 9669600.0 23956700.0 True False 3726159.1186172585 7943984.3310703635 19221647.744405393 1.0 2.131949838475577 5.158568684940744 21.82925785249758 -6.954005891005041 0.5129861417548334 0.9456372719201879 6.478341057408113 0.9994793018944356 0.040057990269377695 0.08191598138937839 0.029605737912679148 0.04590466098843909 0.24984724384306148 1.111716647253951e-07 6.954005891005041 5.532703785487925 LASEK(ub)SEMQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LASEKSEMQR 10 1 Q08117;K7ELE3;Q08117-2 Q08117 AES Amino-terminal enhancer of split 1 8662310.0 1168900.0 1702100.0 5791310.0 True False 1601073.918334752 1626895.5939079977 4423521.853773406 1.0 1.0161277223228409 2.762846738752843 20.61060848501921 -6.908921281648258 0.9030505249612565 0.9440557992702782 2.983448037959884 0.9905080612492129 0.080595046457789 0.10513563804363511 0.14266897898052913 0.06563431982714237 0.1798542310073137 1.233328360769866e-07 6.908921281648258 2.0393922386896057 up LASEK(ub)SEMQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LASEKSEMQR 10 1 Q08117;K7ELE3;Q08117-2 Q08117 AES Amino-terminal enhancer of split 1 33989660.0 2456150.0 5281510.0 26252000.0 True False 3179534.5929546827 4987589.325679579 21474405.36826685 1.0 1.5686538956774503 6.753946132824138 21.60038417459003 -6.927745941232733 0.7650649522878556 0.9142037532144297 7.759837632015378 0.9960764447626745 0.16216008571252694 0.09382524596382032 0.08353785782138501 0.1458011997685628 0.4751275099989533 1.181011315700127e-07 6.927745941232733 6.845633878800948 up LASGEDDPFDSDFSCPVK(ub)LHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LASGEDDPFDSDFSCPVKLHR 21 1 Q99567;J3KMX1 Q99567 NUP88 Nuclear pore complex protein Nup88 1 14572900.0 4143900.0 5023800.0 5405200.0 True False 5432693.029584677 4274268.622619024 4845921.754339563 1.0 0.7867679251050536 0.8919925583776317 22.37323610018993 -10.118547376865319 4.664651088618673 1.0000120673859914 0.8393802417420514 0.756496545643433 0.04295777665729938 5.5491498623742325e-06 1.0485763559198637e-06 0.04159690396146265 0.013864562797362841 7.611191045539097e-11 10.118547376865319 -0.16063182564393996 LASGEDDPFDSDFSCPVK(ub)LHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LASGEDDPFDSDFSCPVKLHR 21 1 Q99567;J3KMX1 Q99567 NUP88 Nuclear pore complex protein Nup88 1 54299000.0 14369000.0 16499000.0 23431000.0 True False 21798823.51461085 13554624.542724635 18799852.57982788 1.0 0.6218053251194741 0.8624251013926103 24.377746938872555 -10.515556894553146 5.939339477005493 1.00034210046323 0.7421152132560421 0.6049830872775561 0.0982326123153052 0.0004455695197084124 3.634294785915013e-05 0.0952374016427557 0.031704439295968875 3.051006307250753e-11 10.515556894553146 -0.2582268872071879 LASGEDDPFDSDFSCPVK(ub)LHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LASGEDDPFDSDFSCPVKLHR 21 1 Q99567;J3KMX1 Q99567 NUP88 Nuclear pore complex protein Nup88 1 13918100.0 4143900.0 5142300.0 4631900.0 True False 5676011.814686779 4915096.182687915 3537940.6169749154 1.0 0.8659418519831158 0.6233145265519766 22.436446161712823 -6.961950736631969 0.4070142537974302 1.0123482699552353 0.4679476697395952 0.9998358342519185 0.00199744083246431 0.07901156461517651 0.018610147117030008 0.0031222528076355065 0.020277570491231474 1.0915641489282413e-07 6.961950736631969 -0.5444006002156401 LASGEDDPFDSDFSCPVK(ub)LHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LASGEDDPFDSDFSCPVKLHR 21 1 Q99567;J3KMX1 Q99567 NUP88 Nuclear pore complex protein Nup88 1 51267000.0 14369000.0 14794000.0 22104000.0 True False 18600953.75533493 13970700.895028835 18081298.806192707 1.0 0.7510744383750703 0.9720629944046186 24.148873260965004 -10.271558821121593 7.115604891663571 1.0000009076838916 0.8615687164981662 0.34348735498927396 0.09021820021114073 1.2991421463582127e-06 1.329013540403559e-07 0.08735397010389966 0.029117798911879548 5.351076735384534e-11 10.271558821121593 -0.13843219118572536 LASHLNLAMCHLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LASHLNLAMCHLK 13 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 208709900.0 78787000.0 72495800.0 57427100.0 False True 103290519.9743932 61679709.22641517 51485094.57164084 1.0 0.5971478238439134 0.49844936964597075 26.622132608524133 -13.99999999999999 0.19754446459564684 3.2188109877416307 0.4327766604335796 0.9994869943576321 0.00491370909650332 12.483369803588541 0.14093918606024347 10.691379806119159 0.06401620706013911 1.0000000000000246e-14 13.99999999999999 -2.7860343273080512 LASHLNLAMCHLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LASHLNLAMCHLK 13 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 97479120.0 72346500.0 8936320.0 16196300.0 False True 70049899.95797187 12504639.17829316 11954003.151415031 1.0 0.17851045020472006 0.17064982474760312 26.06187965447875 LASHLNLAMCHLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LASHLNLAMCHLK 13 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 220041800.0 36203800.0 116096000.0 67742000.0 False True 54923811.45231175 95377761.73781173 54352764.00762659 1.0 1.7365466673889631 0.989602916666099 25.710928409371537 -10.216952585715994 3.9458654958469794 0.9997136217910388 1.36307479207388 0.23956242445564901 0.3049385096134008 216418882.04263103 334330531.9113388 754258.576873722 0.1115961032823296 6.068025739003293e-11 10.216952585715994 0.3633611702828411 LASHLNLAMCHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LASHLNLAMCHLK 13 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 267577500.0 78787000.0 51503100.0 137287400.0 False True 107916683.03861757 49227522.74402383 104862943.6427562 1.0 0.4561623037135783 0.9717028052579358 26.685342670047024 -10.71211189652641 9.951118443718912 1.0003905348740842 0.7139325544857572 0.29104906681207077 0.21046852842036648 0.0018259072034640758 5.282387713686737e-05 0.2040471497945757 0.06792842545607176 1.9403858702908916e-11 10.71211189652641 -0.28645798038832704 LASHLNLAMCHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LASHLNLAMCHLK 13 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 101024700.0 68345000.0 13350700.0 19329000.0 False True 56831895.69686722 13278777.129193543 23370604.532801647 1.0 0.23365008269336188 0.4112233851472584 25.76019750324772 -10.645068295914516 9.845596133887788 1.0002169879611593 0.3224367339671766 0.951010584871944 0.07249399715882576 0.0003453905252482328 1.2451135240705206e-05 0.0702127896962187 0.02339733697467833 2.2642882040735383e-11 10.645068295914516 -0.6777802539939828 LASHLNLAMCHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LASHLNLAMCHLK 13 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 371473800.0 36203800.0 174077000.0 161193000.0 False True 46866532.78358925 164389461.92401877 131857527.97985084 1.0 3.507608780941893 2.8134688048871834 25.482054731463986 -10.200973455382922 10.828026821705457 0.9999999953535997 3.1605387929145383 0.9281465240882448 0.28338145856696206 3.286619451589858e-08 2.265578479026683e-09 0.27438291945776094 0.09146097247115093 6.295446602312995e-11 10.200973455382922 2.1605387975609385 LASLFPALFSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LASLFPALFSR 11 0 Q9UNW1-3;Q9UNW1-2;Q9UNW1 Q9UNW1-3 MINPP1 Multiple inositol polyphosphate phosphatase 1 0 2151940.0 458960.0 877000.0 815980.0 False True 601701.0045749623 746155.0185192255 731550.217032856 1.0 1.2400760724112545 1.2158035493884845 19.198687239870203 -10.064878967558398 4.496195630049177 0.9999860926473879 1.2279398109141286 0.9915671760609932 0.009909216079467847 1143512.6682965462 2559790.0289452896 90.05203341147062 0.003392188226219305 8.612337338156842e-11 10.064878967558398 0.2279537182667407 LASLFPALFSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LASLFPALFSR 11 0 Q9UNW1-3;Q9UNW1-2;Q9UNW1 Q9UNW1-3 MINPP1 Multiple inositol polyphosphate phosphatase 1 0 2962460.0 458960.0 1064500.0 1439000.0 False True 628649.9149276399 1017466.87016924 1099137.837135281 1.0 1.6184952006019988 1.748410062636843 19.261897301393095 -11.361589682512028 0.2779184603652513 4.680876335937116e-17 1.7945631732650438 0.9993049098886596 0.00860852788005181 3.6253236689717703 0.1495804487391878 2.261013775602474 0.051723452270057785 4.3492093948038055e-12 11.361589682512028 1.7945631732650438 LASLGLK(ub)FNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LASLGLKFNK 10 1 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 25884600.0 10209500.0 9822400.0 5852700.0 True False 13384753.368938647 8356936.207415317 5247118.747062672 1.0 0.6243623604457933 0.3920220718627067 23.674087219948742 -8.77255227186144 0.15397007559518253 1.4535539520100014 6.609816861333337e-13 0.9998580315623076 0.0029846368602647632 0.30478378933949285 0.044492828585641006 0.22110853480580261 0.15800931374604135 1.6882926436644386e-09 8.77255227186144 -1.4535539520093403 LASLGLK(ub)FNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LASLGLKFNK 10 1 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 71126700.0 15721400.0 28062300.0 27343000.0 True False 15222332.762459286 39267722.73296129 20181048.027582902 1.0 2.5796126878661982 1.3257526518768927 23.859686127320163 -6.588357848421963 2.234419313653343 2.0701669678894303 1.329249710143955 0.0 0.684773889279886 0.6744037372585306 6.344859163640326 0.25603746675248856 0.7638680411540669 2.580133345425999e-07 6.588357848421963 -0.7409172577454752 LASLGLK(ub)FNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LASLGLKFNK 10 1 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 164462500.0 25784500.0 65887000.0 72791000.0 True False 39116971.59944898 54128950.072519384 58403826.944571316 1.0 1.3837714899504612 1.4930559436608846 25.221291346680193 -12.20752842198403 0.20417965372215147 2.2930671378176712e-11 1.56753842126631 0.9994063467582435 0.005151514447895325 5.789579851320775 0.1293891352166269 2.4811081780829976 0.06716809441233677 6.201140595585094e-13 12.20752842198403 1.5675384212433792 LASLGLK(ub)FNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LASLGLKFNK 10 1 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 31775900.0 10209500.0 9716400.0 11850000.0 True False 13984228.051363396 9287097.320161954 9051274.058410753 1.0 0.6641122617602411 0.6472487451696196 23.737297281471633 -13.999999999999998 0.4267297823600577 7.731881865791552 0.6468414971138302 0.9998721813785345 0.001836709942086531 31.153633061183385 0.2188363409587575 195.9951575148258 0.004023682920977175 1.0000000000000041e-14 13.999999999999998 -7.0850403686777215 LASLGLK(ub)FNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LASLGLKFNK 10 1 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 52386700.0 15721400.0 25690300.0 10975000.0 True False 13073040.676109858 25551901.254774686 13269821.757333443 1.0 1.9545492045679276 1.01505243394394 23.64009140275444 -6.64247426482953 2.035329362269443 1.6230404664938078 1.0189614590070313 0.16421946472892057 0.40817042214732835 0.5271689682381353 4.176701690875386 0.16313243832945445 0.45204467049669345 2.277853217562688e-07 6.64247426482953 -0.6040790074867766 LASLGLK(ub)FNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LASLGLKFNK 10 1 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 74521500.0 25784500.0 48737000.0 0.0 True False 33378543.53848093 46024743.106733866 0.0 1.0 1.3788721204588685 0.0 24.992417668772642 -6.8626152164220375 1.3777696531741512 1.1996963912334797 4.9155796018477594e-21 0.9116649710929011 0.17287290081496579 0.16313649022788412 0.6226088643134315 0.10125268210699409 0.21060567379216055 1.3720969014255198e-07 6.8626152164220375 -1.1996963912334797 down LASLMNLGMSSSLNQQGAHSALSSASTSSHNLQSIFNIGSR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LASLMNLGMSSSLNQQGAHSALSSASTSSHNLQSIFNIGSR 41 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991;D6R8Z5;D6RCM3;D6REK4 P43243 MATR3 Matrin-3 0 127193800.0 69453000.0 16254400.0 41486400.0 False True 67248252.53165005 22744866.685576223 30619867.274677858 1.0 0.3382224196066874 0.45532584300635576 26.002993443454365 -9.972401782018922 6.000063418771979 1.0000004119319557 0.3967741313097715 0.9725124700040679 0.047807272410741 2.63458078151623e-07 4.5064083059823994e-08 0.0462892241959933 0.015429730822813978 1.0656098296857957e-10 9.972401782018922 -0.6032262806221842 LASLMNLGMSSSLNQQGAHSALSSASTSSHNLQSIFNIGSR ddPTM_RPMI8226_Bortezomib_8h_R1 4 LASLMNLGMSSSLNQQGAHSALSSASTSSHNLQSIFNIGSR 41 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991;D6R8Z5;D6RCM3;D6REK4 P43243 MATR3 Matrin-3 0 1558933400.0 457285400.0 409838000.0 691810000.0 False True 693735383.840783 336699206.8210902 555073450.2689056 1.0 0.4853424153702458 0.8001227315173227 29.369810229942622 -10.435795900238789 5.922778254548691 1.000162681305352 0.6427325734437876 0.6320220554202324 0.12850852593871903 0.00027617999733168017 2.6308966098910377e-05 0.12448388640853292 0.0414759484005268 3.66609825047867e-11 10.435795900238789 -0.35743010786156426 LASLMNLGMSSSLNQQGAHSALSSASTSSHNLQSIFNIGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 4 LASLMNLGMSSSLNQQGAHSALSSASTSSHNLQSIFNIGSR 41 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991;D6R8Z5;D6RCM3;D6REK4 P43243 MATR3 Matrin-3 0 292298200.0 154337000.0 44169500.0 93791700.0 False True 128338053.78838833 43931550.13654066 113403110.82617669 1.0 0.34231117614560136 0.8836281015540621 26.935373769524396 -10.231931825961059 7.799120262714092 1.0000003958120172 0.6129696388499002 0.4053260454866011 0.22099170939715856 1.5208602142584075e-06 1.4983420964822807e-07 0.2139745209354006 0.07132476751209202 5.862301816688075e-11 10.231931825961059 -0.387030756962117 LASLMNLGMSSSLNQQGAHSALSSASTSSHNLQSIFNIGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 4 LASLMNLGMSSSLNQQGAHSALSSASTSSHNLQSIFNIGSR 41 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991;D6R8Z5;D6RCM3;D6REK4 P43243 MATR3 Matrin-3 0 1054088400.0 457285400.0 316317000.0 280486000.0 False True 591964964.7428367 298713680.8850099 229440426.02939582 1.0 0.504613784051862 0.3875912253169747 29.140936552035072 -13.999999999999998 0.2027081194540461 3.782612925943112 0.3135876483186851 0.9994872461926596 0.006010736916481642 12.585754387680753 0.1427486009061461 13.90143366548283 0.07303683425539309 1.0000000000000041e-14 13.999999999999998 -3.469025277624427 LASNYISK(ub)AGICHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LASNYISKAGICHK 14 1 Q68D91 Q68D91 MBLAC2 Metallo-beta-lactamase domain-containing protein 2 1 8345300.0 3094200.0 2815900.0 2435200.0 True False 4056526.1642754218 2395778.696292231 2183228.8640878606 1.0 0.5905986056224947 0.5382015980359959 21.95181336302597 -13.999999999999998 0.2898503862129443 4.524828769513971 0.5239017031066574 0.9996271270327514 0.003986623611476694 15.956799840568612 0.17072628985754887 33.53489811631378 0.01980237997659281 1.0000000000000041e-14 13.999999999999998 -4.000927066407313 LASNYISK(ub)AGICHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LASNYISKAGICHK 14 1 Q68D91 Q68D91 MBLAC2 Metallo-beta-lactamase domain-containing protein 2 1 5073520.0 2224200.0 890720.0 1958600.0 True False 2153593.9884655285 1246389.1410434367 1445583.9032594764 1.0 0.5787484306322334 0.6712425420027658 21.038314857256943 -10.572524750350446 6.689756873554272 1.0005180014858126 0.6249954863175085 0.9563645055621329 0.03776056284499402 0.0002921147059038013 1.8666068716465475e-05 0.0366096744795439 0.012187169253506696 2.6759330879944096e-11 10.572524750350446 -0.37552251516830415 LASNYISK(ub)AGICHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LASNYISKAGICHK 14 1 Q68D91 Q68D91 MBLAC2 Metallo-beta-lactamase domain-containing protein 2 1 26321500.0 7145200.0 9660200.0 9516100.0 True False 10839790.784090567 7936261.834512902 7635238.663945204 1.0 0.7321416061056142 0.7043714049491945 23.369833576100017 -13.999999999999998 0.3202448805657788 3.750461879914999 0.6988732251540295 0.9996942505459547 0.0023308033462157156 18.03228557756277 0.18048181473658828 33.23435247448324 0.009236811035195013 1.0000000000000041e-14 13.999999999999998 -3.0515886547609696 LASNYISK(ub)AGICHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LASNYISKAGICHK 14 1 Q68D91 Q68D91 MBLAC2 Metallo-beta-lactamase domain-containing protein 2 1 8821800.0 3094200.0 2260600.0 3467000.0 True False 4238209.357610908 2160719.2171954736 2648166.005106339 1.0 0.509818896349537 0.6248313336269727 22.01502342454886 -9.90373450755811 6.752123019839403 1.0000000171412402 0.5673251149882843 0.9496729386094523 0.046953630900620096 1.2107354140484735e-08 1.906286737065925e-09 0.04546265966284285 0.015154219210168983 1.2481462965372726e-10 9.90373450755811 -0.4326749021529559 LASNYISK(ub)AGICHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LASNYISKAGICHK 14 1 Q68D91 Q68D91 MBLAC2 Metallo-beta-lactamase domain-containing protein 2 1 4691030.0 2224200.0 678630.0 1788200.0 True False 1849520.848766876 674974.0854924911 2162104.352297374 1.0 0.36494537811915667 1.1690078291028219 20.81872013269122 -6.696166952359318 1.8441895133457544 0.6041733283756625 1.1664715568310766 0.3994019329488375 0.2682597428271752 0.4036408293979907 2.6660589334555818 0.11615668258819194 0.30018472927177947 2.0129502787063115e-07 6.696166952359318 0.5622982284554141 LASNYISK(ub)AGICHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LASNYISKAGICHK 14 1 Q68D91 Q68D91 MBLAC2 Metallo-beta-lactamase domain-containing protein 2 1 18129100.0 7145200.0 4866700.0 6117200.0 True False 9249602.252948644 4595863.866826877 5003932.367772439 1.0 0.49687151308174143 0.5409889237320724 23.140959898192467 -9.964119040649338 7.265075289497251 1.0000000143368888 0.5189302194047068 0.9937319215499909 0.018010857477690906 4.17273918436417e-09 6.080635494758538e-10 0.017438938285222454 0.005812979255167538 1.0861278738318209e-10 9.964119040649338 -0.48106979493218194 LASQANIAQVLAELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LASQANIAQVLAELK 15 0 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 5391700.0 741100.0 2993700.0 1656900.0 False True 971589.2768226087 2547051.629351199 1485459.8821070853 1.0 2.621531227352395 1.5288969501238108 19.889987041849643 -10.516473527363322 5.282921909125657 0.9970004068705918 2.075214088738109 0.563539257262407 0.4460660757808105 0.015782103456449 0.0014444767756753099 0.4325260253498608 0.14396720690059472 3.044573567866301e-11 10.516473527363322 1.0782136818675174 LASQANIAQVLAELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LASQANIAQVLAELK 15 0 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 6627470.0 3084000.0 969470.0 2574000.0 False True 2986100.1080962527 1356584.4267192632 1899792.1816552095 1.0 0.4542997145477936 0.6362118190559914 21.509831101519026 -10.10387124457092 5.5526385118040125 1.0000048071553964 0.5452557668017841 0.8928419836861724 0.07426530568054142 4.419552493629949e-06 7.132363550183023e-07 0.071907833515603 0.023969024341755615 7.872791600133656e-11 10.10387124457092 -0.4547490403536123 LASQANIAQVLAELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LASQANIAQVLAELK 15 0 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 7853500.0 741100.0 2533500.0 4578900.0 False True 1015104.6974744506 2421561.592835855 3497458.125405657 1.0 2.3855289004775826 3.445416156685341 19.953197103372535 -7.600107775625035 0.1826054183475829 1.1132203146087182e-21 5.190631831994623 0.9999525702597514 0.006895759849641988 0.13776162204544026 0.02024374238102326 0.1839014137081495 0.32590934463721694 2.5112631527138973e-08 7.600107775625035 5.190631831994623 LASQANIAQVLAELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LASQANIAQVLAELK 15 0 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 6555900.0 3084000.0 1331900.0 2140000.0 False True 2564482.6443651835 1324724.7903385498 2587464.1057579564 1.0 0.5165660969666942 1.008961441577025 21.290236376953303 -10.829347969336075 11.176125052383224 1.0029373289087768 0.7627637692980569 0.23635483740390917 0.20101955766953222 0.014810072261733741 0.000226139573164396 0.19592812363616008 0.06487878325967328 1.481330724391578e-11 10.829347969336075 -0.24017355961071996 LASTLVHLGEYQAAVDGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LASTLVHLGEYQAAVDGAR 19 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 27822000.0 6367000.0 9039000.0 12416000.0 False True 8347198.658115701 7690416.433746033 11131311.422681868 1.0 0.9213170488363662 1.3335385772637947 22.992860675876795 -6.857271706464637 1.199397924046056 0.9575804290283354 1.3524891962437082 0.9502411119173937 0.039859463313505344 0.14964043050151463 0.4106019072548526 0.025946685268437585 0.060395092128172775 1.3890833109274955e-07 6.857271706464637 0.3949087672153728 LASTLVHLGEYQAAVDGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LASTLVHLGEYQAAVDGAR 19 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 15547800.0 4610500.0 1760000.0 9177300.0 False True 4464142.2011601105 2462777.1782787517 6773489.816901458 1.0 0.5516798227526762 1.517310495875604 22.08995155295207 -6.780484199513569 1.5342347572815127 0.7463080571633465 1.525042163589731 0.7690160482446372 0.18962495630812687 0.2498235859237105 1.1615909562933249 0.09734866513157056 0.22958509236672509 1.6577376475040367e-07 6.780484199513569 0.7787341064263846 LASTLVHLGEYQAAVDGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LASTLVHLGEYQAAVDGAR 19 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 21215200.0 6367000.0 5602600.0 9245600.0 False True 8721051.961705334 5355058.606679357 7061979.699109071 1.0 0.6140381493188829 0.8097623692782304 23.056070737399686 -10.126160477257217 5.3085422103029245 1.0000066180318925 0.7119002592983831 0.7428591172115939 0.07990407820138438 6.258747526767389e-06 1.0303008516475877e-06 0.07736856825551829 0.025788930347247028 7.47893093569556e-11 10.126160477257217 -0.2881063587335094 LASTLVHLGEYQAAVDGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LASTLVHLGEYQAAVDGAR 19 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 10452000.0 4610500.0 1468200.0 4373300.0 False True 3833835.0297813504 1460290.515185117 5287736.8101454545 1.0 0.3808955011995912 1.379229092819631 21.870356828386345 -6.73899591604398 1.6905281350241192 0.6311997923526175 1.3796675735089396 0.6003347588080505 0.26012815663630595 0.3196484821878913 1.793339963191798 0.12175263264736809 0.29908199328149854 1.8239128536885035e-07 6.73899591604398 0.7484677811563222 LASTLVHLGEYQAAVDGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LASTLVHLGEYQAAVDGAR 19 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 13079800.0 2310700.0 4812700.0 5956400.0 False True 2991246.7007065476 4544869.014296688 4872396.317825104 1.0 1.5193895619586197 1.6288848113645122 21.51231546982111 -11.651856323715512 0.2663232103321253 1.5260062054025302e-09 1.6713139941540758 0.9993445000835881 0.0070232753075251285 4.290055805611337 0.14838490245229005 2.4774132699789657 0.04620200413123898 2.2291724974582663e-12 11.651856323715512 1.6713139926280696 LASVLGSEPSLDSEVTSKLK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LASVLGSEPSLDSEVTSKLK 20 1 G3V1D3;G3V180;Q9NY33;Q9NY33-4;E9PQ14 G3V1D3 DPP3 Dipeptidyl peptidase 3 1 16478600.0 1689400.0 3401200.0 11388000.0 True False 1635770.9217308057 4759316.897023688 8405141.167323055 1.0 2.9095253093189024 5.138336337724841 20.641539292406236 -6.969090517555369 0.27905407248024217 0.5033566503600743 7.612334052886445 0.9999743944432347 0.008557513827891801 0.07659892160769352 0.010082015060709137 0.041394444698211325 0.2048222610485719 1.0737655900964904e-07 6.969090517555369 7.108977402526371 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK 33 0 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 0 223503000.0 49002000.0 111332000.0 63169000.0 False True 64242096.53604297 94721699.56873696 56632877.83983496 1.0 1.4744490711879776 0.8815540104308571 25.937015640080414 -6.69360514233499 1.8534945971302816 1.296439184097658 0.8835044960140969 0.3873690478849511 0.20051436706901365 0.40898371959451163 2.7268118229279823 0.08645278028554278 0.2241205849162735 2.0248593307098544e-07 6.69360514233499 -0.41293468808356104 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK 33 0 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 0 163197200.0 40631200.0 33468000.0 89098000.0 False True 39341384.79639443 46831946.93331434 65760560.91729442 1.0 1.190399046085597 1.671536506852226 25.22954440484092 -6.955231005303238 0.49811802651884757 0.9902051239652796 1.8924160035831257 0.999550417744242 0.005991821412233684 0.08145076497637371 0.027777035595387148 0.007051980744889895 0.039687202265626755 1.1085849916680678e-07 6.955231005303238 0.9022108796178461 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK 33 0 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 0 592515000.0 62554000.0 436220000.0 93741000.0 False True 94898991.30997041 358373132.7975842 75213050.2618602 1.0 3.7763639829112945 0.7925590064091447 26.49988941700231 -6.662355125875703 1.9644535011749475 2.7836282829983556 0.804921370731507 0.24569731901831882 1.181449151654872 0.47888485906811595 3.555021830262238 0.485468115015928 1.3101276260858874 2.1759297704956324e-07 6.662355125875703 -1.9787069122668486 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK 33 0 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 0 189085000.0 49002000.0 63195000.0 76888000.0 False True 67119363.62925787 60402835.94208081 58728637.9580663 1.0 0.8999315946397133 0.8749880032007039 26.000225701603306 -13.999999999999998 0.1950986091549009 1.5462152025867428 0.8579830777480614 0.9994873929346603 0.001223053754443096 12.438238573990871 0.14007043834130406 2.5874912842145634 0.016483463836018047 1.0000000000000041e-14 13.999999999999998 -0.6882321248386815 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK 33 0 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 0 75541000.0 40631200.0 19008800.0 15901000.0 False True 33786643.067357525 18906395.821448624 19225825.582082845 1.0 0.5595819562114108 0.5690362769616967 25.009949680275195 -10.516811863778296 6.214365568289806 1.0004329829109944 0.5643091165865538 0.9996469691910438 0.00385971028380127 2.317601446388169e-05 1.8020138826178678e-06 0.003740718086470121 0.0012457161375289834 3.0422026214045336e-11 10.516811863778296 -0.43612386632444056 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK 33 0 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 0 218527000.0 62554000.0 97099000.0 58874000.0 False True 80977386.12368426 91695355.29311916 48159536.09825323 1.0 1.1323575590976023 0.594728212450507 26.27101573909476 -6.841584608145788 1.275012700240921 1.070402540575166 0.5764827221608648 0.9271463818676162 0.0617343260934854 0.16695477866337685 0.5265322161094019 0.0379562263418665 0.08748457735078516 1.4401754116057232e-07 6.841584608145788 -0.4939198184143012 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK(ub)KDEK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEK 37 2 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 2 47003600.0 11790000.0 27591000.0 7622600.0 True False 15262387.415644702 26055536.59556172 6235365.014480841 1.0 1.7071730579223476 0.40854453793312073 23.86347731729546 -6.758826671361472 1.6168660017476655 1.4113625319674017 0.404069092753415 0.6861740998626618 0.2973908971681578 0.2848897493826847 1.4676065264643714 0.145140834599467 0.34920450287845334 1.74250217411562e-07 6.758826671361472 -1.0072934392139867 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEK 37 2 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 1 148175000.0 43130000.0 64117000.0 40928000.0 True False 56543847.67151413 54550993.52610844 36693163.1690982 1.0 0.9647555971609328 0.6489329021658287 25.752866722614822 -6.928049253192959 0.7626352868888256 1.0051663586874149 0.5872038067823381 0.9961407336568853 0.009805777176604509 0.09366356876011543 0.08273604770583615 0.008831973324774967 0.028889134860596494 1.1801867834706469e-07 6.928049253192959 -0.4179625519050768 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEK 37 2 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 1 171850000.0 52611000.0 54146000.0 65093000.0 True False 50940892.60280545 75766780.16765973 48043190.551858045 1.0 1.4873469288892487 0.9431163864060792 25.60232090341451 -6.67065220969126 1.9349414852746039 1.3109053049865358 0.9453080465956943 0.2818694746503444 0.20698512487227433 0.459697579252139 3.3187227634413885 0.08609665709144979 0.22984324201755538 2.1347537754578347e-07 6.67065220969126 -0.36559725839084145 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEK 37 2 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 1 561040000.0 187880000.0 267680000.0 105480000.0 True False 285027695.8678463 219910412.6066144 84631831.76647374 1.0 0.7715405056937917 0.2969249409563114 28.086526870481034 -6.959295209068243 0.44526089054907075 1.0160688415684647 0.03372963572371208 0.9997431441335911 0.004693173449183201 0.07995393473243907 0.022069379158088077 0.006300787128300989 0.039287921644253 1.0982590506487161e-07 6.959295209068243 -0.9823392058447525 down LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEK 37 2 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 1 162590000.0 52611000.0 82538000.0 27441000.0 True False 43748377.56248272 82093351.4114898 33178786.22715141 1.0 1.87648904909083 0.7584003813573312 25.382726178848785 -6.697608658384667 1.8390184880463518 1.5455487310417735 0.7618399024548642 0.4062458038605675 0.3701448060764645 0.4006068168458682 2.632225433208098 0.1606592955843017 0.4144555491674835 2.006279065873278e-07 6.697608658384667 -0.7837088285869093 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEKKDEK 37 2 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 1 620790000.0 187880000.0 328920000.0 103990000.0 True False 243214363.66847545 310615312.85608256 85064887.02750537 1.0 1.2771256934458077 0.3497527273654651 27.857653192573483 -6.826597492939517 1.3429224868455116 1.148463008726052 0.32646672792773695 0.8989228672664877 0.1235712083059059 0.18504518324892114 0.6538311348616019 0.07226979335180403 0.16636568700249232 1.4907420674782578e-07 6.826597492939517 -0.821996280798315 down LATASEK(ub)GTVIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LATASEKGTVIR 12 1 Q9Y4P8-3;Q9Y4P8-2;Q9Y4P8-4;Q9Y4P8-5;Q9Y4P8-6;Q9Y4P8 Q9Y4P8-3 WIPI2 WD repeat domain phosphoinositide-interacting protein 2 1 4099610.0 446480.0 984730.0 2668400.0 True False 432306.7367907954 1377937.824299112 1969465.9897159135 1.0 3.1874077062230293 4.555714316034335 18.72169579287961 -8.393452136616334 0.252552455380392 4.490807966340777e-17 5.637215107809444 0.9993492518904662 0.037356415692622935 0.12670892510545106 0.06394027671802535 0.5530402496903907 0.5095228134924232 4.041549137756385e-09 8.393452136616334 5.637215107809444 LATASEK(ub)GTVIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LATASEKGTVIR 12 1 Q9Y4P8-3;Q9Y4P8-2;Q9Y4P8-4;Q9Y4P8-5;Q9Y4P8-6;Q9Y4P8 Q9Y4P8-3 WIPI2 WD repeat domain phosphoinositide-interacting protein 2 1 15035500.0 1189100.0 2072400.0 11774000.0 True False 1803951.6348544592 1702564.0282648958 9446863.73927248 1.0 0.9437969374396541 5.2367610953353765 20.782729228820468 -6.903933135231416 0.9360499435959432 0.8402594546467843 5.725203959829697 0.9884239892239479 0.21632491024594533 0.10856842323450908 0.16153468051820474 0.17195866328914533 0.45692492815435226 1.2475755784631704e-07 6.903933135231416 4.884944505182913 up LATASEK(ub)GTVIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LATASEKGTVIR 12 1 Q9Y4P8-3;Q9Y4P8-2;Q9Y4P8-4;Q9Y4P8-5;Q9Y4P8-6;Q9Y4P8 Q9Y4P8-3 WIPI2 WD repeat domain phosphoinositide-interacting protein 2 1 11120000.0 1189100.0 1923300.0 8007600.0 True False 1539313.390665233 1816266.6642834232 6550298.964914428 1.0 1.1799200054372954 4.255338129738244 20.553855550912917 -6.918910490212685 0.8327728111397922 0.9294415353913529 4.739049531090676 0.9938727740081955 0.11694369697506674 0.09881704768441445 0.10896914033754988 0.10018191936033842 0.29703460493167977 1.2052843285771063e-07 6.918910490212685 3.809607995699323 up LATATETYIK(ub)PISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LATATETYIKPISK 14 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 17500800.0 1389800.0 4160000.0 11951000.0 True False 2108428.207989848 3417615.4977716478 9588879.611690624 1.0 1.620930456546094 4.547880537432457 21.00773646799109 -6.941128141884456 0.6489826169108873 0.9676786535285822 5.364091625291912 0.9983079724837425 0.06363642662035617 0.08725570420031481 0.05229390884372827 0.06248821548916737 0.25069101142420075 1.1451749990130468e-07 6.941128141884456 4.396412971763329 LATATETYIK(ub)PISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LATATETYIKPISK 14 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 12848000.0 1389800.0 3441600.0 8016600.0 True False 1799123.497053689 3250071.934590461 6557661.057262229 1.0 1.806475175224435 3.6449199112797404 20.77886279008354 -6.95740748941332 0.47054886011649094 0.951699705962054 4.575132424930559 0.9996616364836103 0.020359971909837273 0.0806405356767795 0.024654102794393694 0.025445776815317084 0.15173107325516474 1.1030431719104834e-07 6.95740748941332 3.6234327189685054 LATDK(ub)TQCYDPSTNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LATDKTQCYDPSTNK 15 1 A0A0C4DGF2;Q8WZ60 A0A0C4DGF2 KLHL6 Kelch-like protein 6 1 14701700.0 3871100.0 4330500.0 6500100.0 True False 5075049.587785729 3684406.2801567903 5827532.005361986 1.0 0.7259842916656734 1.1482709487976785 22.2749904881152 -6.731556547945935 1.7175983976866174 0.8353868049645692 1.1480906657993961 0.5664795045957493 0.11517587267168776 0.33331214946069304 1.9271200207657955 0.05312488479111608 0.13159192860435215 1.855425205361844e-07 6.731556547945935 0.31270386083482693 LATDK(ub)TQCYDPSTNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LATDKTQCYDPSTNK 15 1 A0A0C4DGF2;Q8WZ60 A0A0C4DGF2 KLHL6 Kelch-like protein 6 1 8158000.0 1139900.0 2934600.0 4083500.0 True False 1103714.498449713 4106401.0837368327 3013908.847625896 1.0 3.720528351765533 2.730696073902498 20.073935602908666 -10.32775972741047 5.938991939325795 0.9997735312896705 3.2256122128339944 0.8708151794604051 0.40409733528354913 0.0012118827450600723 0.00013717209891349902 0.39130157473644306 0.13042185414999635 4.701541485466372e-11 10.32775972741047 2.2258386815443236 LATDK(ub)TQCYDPSTNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LATDKTQCYDPSTNK 15 1 A0A0C4DGF2;Q8WZ60 A0A0C4DGF2 KLHL6 Kelch-like protein 6 1 51703800.0 9297800.0 23902000.0 18504000.0 True False 14105442.360230247 19636501.352821626 14846676.289408674 1.0 1.3921223348645901 1.0525494989982243 23.749748575147656 -10.408005344732038 6.404646942196798 0.9999640670505796 1.2223359169314072 0.3637057158817154 0.1386300297304098 7.114056924414244e-05 6.575663558786634e-06 0.1342496044388669 0.04474264970250969 3.9083608586022345e-11 10.408005344732038 0.2223718498808276 LATDK(ub)TQCYDPSTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LATDKTQCYDPSTNK 15 1 A0A0C4DGF2;Q8WZ60 A0A0C4DGF2 KLHL6 Kelch-like protein 6 1 16465000.0 3871100.0 4905400.0 7688500.0 True False 5302350.282543988 4688663.208011453 5872634.649627935 1.0 0.8842613102056137 1.1075531295926253 22.338200549638092 -6.765855136275615 1.5904897716900996 0.9332631370340176 1.1086117230536514 0.7143721214125036 0.048729811516471586 0.273196431011455 1.363249418960064 0.024160094066902418 0.05772852938511868 1.7145291122720864e-07 6.765855136275615 0.17534858601963377 LATDK(ub)TQCYDPSTNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LATDKTQCYDPSTNK 15 1 A0A0C4DGF2;Q8WZ60 A0A0C4DGF2 KLHL6 Kelch-like protein 6 1 9582400.0 1139900.0 3197400.0 5245100.0 True False 947877.3561322534 3180174.9715657937 6341826.159397684 1.0 3.3550489955180205 6.690555606555534 19.854340878342942 -6.9661938391506615 0.33693909993962295 0.6251449950162989 9.530794997404655 0.9999356774931669 0.018724001734510786 0.0775581964224815 0.013444461770024285 0.04753930683228748 0.2893598739655958 1.0809513813519783e-07 6.9661938391506615 8.905650002388356 LATFWYYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LATFWYYAK 9 0 E9PN17;A0A3B3ITX4;O75964 E9PN17 ATP5L ATP synthase subunit g, mitochondrial 0 18050600.0 3904200.0 8025900.0 6120500.0 False True 5118444.008326581 6828467.004713171 5487209.371981667 1.0 1.3340903980984768 1.0720463803169844 22.287273871220183 -10.441494603331732 4.996703582670308 0.9996711813763819 1.2030683892077458 0.4446632843070575 0.1069790222856289 0.0003924974311010145 4.3871287040135917e-05 0.103748229145556 0.03452733097547523 3.618306869167833e-11 10.441494603331732 0.20339720783136395 LATFWYYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LATFWYYAK 9 0 E9PN17;A0A3B3ITX4;O75964 E9PN17 ATP5L ATP synthase subunit g, mitochondrial 0 13481700.0 3904200.0 4678300.0 4899200.0 False True 5347688.247037849 4471597.236930723 3742109.8621912235 1.0 0.8361738811920453 0.6997621569028495 22.350483932743074 -6.973231550781936 0.16349524311331387 1.1316211582502187 0.4006839082346546 0.9999978659474791 0.00017921309701987795 0.07526739018452364 0.005065020545164592 0.006107633071337159 0.01616340372467542 1.063575805231555e-07 6.973231550781936 -0.7309372500155641 LATFWYYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LATFWYYAK 9 0 E9PN17;A0A3B3ITX4;O75964 E9PN17 ATP5L ATP synthase subunit g, mitochondrial 0 27787000.0 5257300.0 13679000.0 8850700.0 False True 6805678.486876071 12917751.6251926 7239963.415850961 1.0 1.8980843203367486 1.0638121430232643 22.69830756659451 -10.444154414976241 4.3766103303269475 0.9982242656927873 1.4809482316810054 0.30705621121289317 0.340590190173753 0.005921204090942098 0.0007520143851874262 0.3308851943267699 0.1099250112014941 3.596214477132307e-11 10.444154414976241 0.4827239659882181 LATK(ub)EQEMQECTTQIQYLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LATKEQEMQECTTQIQYLK 19 1 Q15007;A0A087X1R4;Q15007-2 Q15007;A0A087X1R4 WTAP Pre-mRNA-splicing regulator WTAP 1 6791800.0 2311600.0 1686000.0 2794200.0 True False 2238219.523305867 2359228.592373847 2062315.1957968117 1.0 1.0540648796098646 0.92140881371223 21.09392011129223 -6.7960699939859435 1.4720271546491925 1.0299806596124175 0.9197531167182397 0.8203726479210776 0.023083303868180017 0.22642603418207408 0.9690083425758211 0.01233916634705796 0.028766217757752576 1.5993002532451202e-07 6.7960699939859435 -0.1102275428941778 LATLLGLQAPPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LATLLGLQAPPTR 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 14607000.0 4591700.0 4277500.0 5737800.0 False True 6019763.166086053 3639313.673564406 5144107.49686404 1.0 0.6045609392189139 0.8545365249325334 22.521275297864904 -10.512079771088683 5.884418279443395 1.000363883453593 0.7295487320757237 0.6094829656826619 0.10205210552528822 0.00048782378696000223 4.044881190170288e-05 0.09894206178555387 0.03293717542873692 3.075531850028021e-11 10.512079771088683 -0.2708151513778694 LATLLGLQAPPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LATLLGLQAPPTR 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 9621600.0 3598100.0 1451900.0 4571600.0 False True 3483880.2850003634 2031651.2415584782 3374160.8149397704 1.0 0.5831575930739153 0.9685065326346076 21.732263619436704 -10.467405945261302 8.833170115756849 1.0000044266950727 0.7758320628542614 0.31091919900283804 0.15731804580771508 1.3714663108237776e-05 8.270625733034258e-07 0.15232555027496691 0.050774180955931336 3.4087413959199473e-11 10.467405945261302 -0.2241723638408113 LATLLGLQAPPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LATLLGLQAPPTR 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 18298500.0 4591700.0 6498000.0 7208800.0 False True 6289375.576026767 6210896.873987528 5506229.909896322 1.0 0.9875220200971339 0.875481173502253 22.584485359387795 -6.928013581745412 0.762918662688232 1.0018352557921961 0.8536014410348763 0.9961332589712469 0.003481620286372438 0.09368248177884334 0.08282929047616534 0.003135222134687196 0.010250731891015772 1.1802837239146906e-07 6.928013581745412 -0.14823381475731978 LATLLGLQAPPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LATLLGLQAPPTR 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 7806200.0 3598100.0 1955200.0 2252900.0 False True 2991979.5728567964 1944666.9495231854 2723970.973767338 1.0 0.6499599686993792 0.9104243219035218 21.51266889487098 -10.345904759863709 5.499934024614393 1.0000555341160533 0.7801921453014569 0.48706728515294095 0.10633412692237827 7.242755098446076e-05 8.61361238489567e-06 0.1029835370543859 0.0343191918919881 4.5091557881778614e-11 10.345904759863709 -0.21986338881459644 LATNAAVTVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LATNAAVTVLR 11 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 109755000.0 27537000.0 48918000.0 33300000.0 False True 36101273.668687336 41619625.08087056 29854435.436155435 1.0 1.152857526934558 0.8269634946993536 25.105546401132415 -6.779153361764486 1.5390373366399976 1.08664820519472 0.8244447844501654 0.7644030891161564 0.06461939831572562 0.2519054442556895 1.1784665281147182 0.033070689786492025 0.07809265394391357 1.6628253556362315e-07 6.779153361764486 -0.2622034207445545 LATNAAVTVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LATNAAVTVLR 11 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 71941000.0 20327000.0 15257000.0 36357000.0 False True 19681730.511437245 21349199.664203912 26834011.013379373 1.0 1.0847216738283092 1.3633969328960107 24.23035373908122 -6.9493655316826475 0.5657757235239097 0.9964595674291545 1.4651098670618967 0.9991504781562903 0.0045247066754528845 0.08374170404813033 0.03702592133086755 0.004817076149120571 0.023195600397807867 1.123658828394691e-07 6.9493655316826475 0.4686502996327422 LATNAAVTVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LATNAAVTVLR 11 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 305949000.0 61780000.0 150760000.0 93409000.0 False True 93724776.72299087 123855700.10674375 74946670.2073809 1.0 1.3214830105470041 0.7996462923447685 26.481927147850882 -6.740034542818324 1.6866029168253673 1.1912724874884688 0.7993395796901487 0.6050982943511449 0.1350731052256108 0.31774635483397934 1.7747769253694652 0.06335609665186175 0.15546227733784213 1.8195561294018726e-07 6.740034542818324 -0.39193290779832013 LATNAAVTVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LATNAAVTVLR 11 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 93779000.0 27537000.0 23045000.0 43197000.0 False True 37718173.05944401 22026795.700375862 32994758.27014086 1.0 0.5839836321250643 0.8747708490053581 25.168756462655306 -10.12132263786782 5.6460223379000745 1.000002960276678 0.7293772405651784 0.5359255192546406 0.11871338418024097 4.423590771331067e-06 6.886494462997012e-07 0.1149449970035447 0.03831457999181611 7.562708517939099e-11 10.12132263786782 -0.2706257197114996 LATNAAVTVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LATNAAVTVLR 11 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 55095000.0 20327000.0 19905000.0 14863000.0 False True 16902801.13878438 19797767.81416683 17970784.58125255 1.0 1.171271415406988 1.063183813954814 24.010759014515497 -10.1621801845594 5.420889790420161 0.9999966326649674 1.1172276146809266 0.6106470677447824 0.044126578513280446 1.7959572762531253e-06 2.7753904491086335e-07 0.04272660272603198 0.014241791975574267 6.883666404619272e-11 10.1621801845594 0.11723098201595916 LATNAAVTVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LATNAAVTVLR 11 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 243290000.0 61780000.0 116850000.0 64660000.0 False True 79975427.8658633 110347194.7805948 52892543.46762671 1.0 1.3797637315010276 0.6613599311570969 26.253053469943332 -6.7630911030377545 1.600822727869126 1.2197443415180729 0.6583279984504389 0.7034200420022845 0.15980889428663556 0.2777779267280953 1.4036243028441515 0.07874012938619263 0.1886528609090946 1.7254758966364323e-07 6.7630911030377545 -0.561416343067634 LATNTSAPDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LATNTSAPDLK 11 0 P27816-6;P27816;E7EVA0;P27816-2;P27816-5;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 3078280.0 1100700.0 427680.0 1549900.0 False True 1065758.8809927178 598454.8543217365 1143934.6939966637 1.0 0.5615293149274969 1.0733522510561937 20.023449646686327 -6.679899776723972 1.9020985284354068 0.7225507657309171 1.0714089368551047 0.3237105367394768 0.18583819434956186 0.43875703861753945 3.0689838754573766 0.07839662320528244 0.20680337893422537 2.0897783388369993e-07 6.679899776723972 0.3488581711241876 LATQLTGPVMPVR ddPTM_RPMI8226_Bortezomib_1h_R1 2 LATQLTGPVMPVR 13 0 P26373;P26373-2 P26373 RPL13 60S ribosomal protein L13 0 67543600.0 16097000.0 25521200.0 25925400.0 False True 21103322.883569725 21713536.440858446 23242888.3019971 1.0 1.0289155201128923 1.101385238250473 24.330966844670467 -6.955408005703146 0.49593344216596497 0.9984960757735661 1.134908833154777 0.9995601574713278 0.000894338596005019 0.08138411858499009 0.02751716406774853 0.0010570268784728164 0.005977442082743788 1.1081332705090317e-07 6.955408005703146 0.13641275738121084 LATQLTGPVMPVR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LATQLTGPVMPVR 13 0 P26373;P26373-2 P26373 RPL13 60S ribosomal protein L13 0 53040000.0 17850100.0 7946500.0 27243400.0 False True 17283458.346150763 11119578.890450064 20107536.25551887 1.0 0.6433653883238322 1.1633977328384086 24.042888587710337 -6.722106882317056 1.7515434838012929 0.7835217048028408 1.1626959235715109 0.5225413775289639 0.1500353954488172 0.3512329378181671 2.1069526526602664 0.06798212469131296 0.17025139917904974 1.8962391886406744e-07 6.722106882317056 0.3791742187686701 LATQLTGPVMPVR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LATQLTGPVMPVR 13 0 P26373;P26373-2 P26373 RPL13 60S ribosomal protein L13 0 67209700.0 16097000.0 22933300.0 28179400.0 False True 22048495.905068442 21920030.97571839 21524006.09296036 1.0 0.9941735286659386 0.9762119913137697 24.39417690619336 -6.950844518743079 0.5495762516328617 1.0002490304837446 0.96929342019111 0.9992650442755937 0.00027439799401403103 0.08315000185038426 0.03458421410181824 0.0002979877209971315 0.0014899176044736709 1.1198387238557474e-07 6.950844518743079 -0.030955610292634606 LATQLTGPVMPVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LATQLTGPVMPVR 13 0 P26373;P26373-2 P26373 RPL13 60S ribosomal protein L13 0 22031300.0 13739000.0 4366200.0 3926100.0 False True 11424587.240899228 4342678.413977156 4747029.357764628 1.0 0.3801168762080673 0.4155099223865693 23.44563870728352 -9.994020754380141 5.569196536099258 1.0000015039553285 0.39781339929677084 0.997415888048424 0.014449150598612029 2.698214207166228e-07 4.875682589954006e-08 0.013990364821728558 0.004663443302658627 1.0138629333606937e-10 9.994020754380141 -0.6021881046585577 LATQLTGPVMPVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LATQLTGPVMPVR 13 0 P26373;P26373-2 P26373 RPL13 60S ribosomal protein L13 0 17345500.0 5544100.0 8715300.0 3086100.0 False True 7176946.7405492505 8230285.893635584 2524461.46606005 1.0 1.1467670293740708 0.351745882660243 22.77493878396868 -6.859036289405318 1.1905948554222516 1.079433235248995 0.31394830489318626 0.9524623216331697 0.0753123184355143 0.14779326398637815 0.3986376156655413 0.04935608309626127 0.1150897917164569 1.3834507737648264e-07 6.859036289405318 -0.7654849303558088 down LATQSNEITIPVTFESR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LATQSNEITIPVTFESR 17 0 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 0 263082000.0 56429000.0 127360000.0 79293000.0 False True 73978965.4592133 108358384.44539157 71088520.99216434 1.0 1.4647188396427713 0.960928833633899 26.140611789797823 -6.664273439970684 1.9578526254529844 1.2980793177308454 0.9630159111185589 0.25386128362592086 0.19766725482573613 0.47440170410752297 3.5001195722307763 0.08144501201607736 0.21922433305669964 2.1663397071320452e-07 6.664273439970684 -0.3350634066122865 LATQSNEITIPVTFESR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LATQSNEITIPVTFESR 17 0 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 0 242363000.0 70323000.0 41470000.0 130570000.0 False True 68090634.85786407 58029187.263193056 96369799.98396298 1.0 0.8522344869353355 1.4153165143067077 26.02095304874515 -6.836969238489803 1.2964174782948128 0.9213361321571121 1.4327504865476068 0.9191133049796553 0.06779392556406384 0.17236836909893496 0.564051951598714 0.04102442171441694 0.09444834771939038 1.4555621758476873e-07 6.836969238489803 0.5114143543904948 LATQSNEITIPVTFESR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LATQSNEITIPVTFESR 17 0 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 0 481442000.0 24298000.0 410050000.0 47094000.0 False True 36861842.421742246 336873373.7647268 37785850.257966526 1.0 9.13880998975864 1.0250667838479846 25.135624845497105 -6.645531296930524 2.0254629983195733 6.2999879906417595 1.0596567992620483 0.17588652411743233 3.4776061975390014 0.5194754136596393 4.079967134983966 1.395280255568771 3.8490465018938624 2.2618755344468328e-07 6.645531296930524 -5.2403311913797115 LATQSNEITIPVTFESR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LATQSNEITIPVTFESR 17 0 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 0 263019000.0 56429000.0 101880000.0 104710000.0 False True 77292326.23638614 97378604.72789297 79979654.57014257 1.0 1.2598741617644704 1.0347683717726086 26.203821851320715 -10.52306060979081 3.300140076015866 0.9960770629498882 1.1473212668057 0.36349481964884955 0.09189905429529051 67176072.50169213 76780511.4476949 2326432.6394437943 0.033631583748479126 2.9987439874690416e-11 10.52306060979081 0.15124420385581183 LATQSNEITIPVTFESR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LATQSNEITIPVTFESR 17 0 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 0 141156000.0 70323000.0 38947000.0 31886000.0 False True 58476690.33712477 38737184.78062577 38553215.17579358 1.0 0.6624380510815762 0.6592920179567262 25.801358324179425 LATQSNEITIPVTFESR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LATQSNEITIPVTFESR 17 0 P04792;C9J3N8 P04792 HSPB1 Heat shock protein beta-1 0 131338000.0 24298000.0 60216000.0 46824000.0 False True 31454239.985185325 56864926.66588192 38302512.45481212 1.0 1.8078620463462098 1.2177217593829088 24.906751167589555 -9.957649979898083 5.248858175065714 0.9999982670221828 1.512791902867736 0.5016754277957702 0.2409237632977242 4.885796859835679e-06 9.701996539323283e-07 0.2332742196932907 0.07775781024487516 1.1024274541778852e-10 9.957649979898083 0.5127936358455532 LATTILQHWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LATTILQHWK 10 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 8248500.0 2257300.0 2586300.0 3404900.0 False True 2959342.1597242975 2200434.121318439 3052593.610107078 1.0 0.743555156029487 1.0315108714537653 21.496845080184976 -6.671811028016282 1.9310664801732897 0.8365678431438155 1.0303540870968204 0.28707621086936896 0.1088868648334813 0.45695299540033274 3.2868683725164556 0.0453680366824261 0.1209214756708837 2.1290652520043337e-07 6.671811028016282 0.19378624395300492 LATTILQHWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LATTILQHWK 10 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 5769400.0 2257300.0 1240200.0 2271900.0 False True 3091884.811238807 1185403.863207036 1735324.0112492295 1.0 0.38339198759868653 0.56125118404846 21.560055141707867 -10.896174943240927 11.330808188439557 1.0351517965097987 0.47232158582357325 0.9214831848771485 0.07261071289389638 0.03736099000637803 0.0003423409520648618 0.0407374153727156 0.023435006816192403 1.2700623934604006e-11 10.896174943240927 -0.5628302106862255 LAVDEEENADNNTK(ub)ANVTKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAVDEEENADNNTKANVTKPK 21 2 P02786;F8WBE5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 1 31879000.0 11429000.0 12999000.0 7451000.0 True False 14983529.67859345 11059599.869705142 6680041.995038864 1.0 0.7381171264008429 0.44582565912906713 23.83687418453447 -6.969704935290213 0.2651443657677686 1.0770745735159768 0.0981376484758722 0.999979986445933 0.0010126133938529371 0.07639862211535474 0.009372458632195579 0.005904832155956591 0.027370825807371484 1.072247555248331e-07 6.969704935290213 -0.9789369250401045 down LAVDEEENADNNTK(ub)ANVTKPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAVDEEENADNNTKANVTKPK 21 2 P02786;F8WBE5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 1 50426000.0 23899000.0 10314000.0 16213000.0 True False 36256530.250934914 8473386.11635019 13008493.443589646 1.0 0.23370648150016218 0.35879035731098974 25.111737530019237 -9.959152293483616 5.911221650974923 1.000000495151239 0.2962484194986765 0.9768550999306244 0.05106527846511848 3.3327634012220424e-07 5.858044675238049e-08 0.049443777891725854 0.016481247755293766 1.0986205200415475e-10 9.959152293483616 -0.7037520756525624 LAVDEEENADNNTK(ub)ANVTKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAVDEEENADNNTKANVTKPK 21 2 P02786;F8WBE5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 1 27618500.0 11429000.0 8022300.0 8167200.0 True False 15654610.157111736 7667848.259801498 6238275.568763914 1.0 0.48981406645364906 0.398494469434611 23.90008424605736 -13.999999999999998 0.241982583255025 4.409675717395416 0.35887045548384094 0.9995282939129889 0.005748246840575831 13.69427566585754 0.1556837885634605 22.589303595566623 0.044108372754337405 1.0000000000000041e-14 13.999999999999998 -4.050805261911575 LAVDEEENADNNTK(ub)ANVTKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAVDEEENADNNTKANVTKPK 21 2 P02786;F8WBE5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 1 56347000.0 23899000.0 12719000.0 19729000.0 True False 30937726.619719442 12011176.469100429 16138524.436634796 1.0 0.38823720361678443 0.521645453623869 24.882863852111686 -9.923899188858767 6.950422499313016 1.0000000180754 0.4549413286211384 0.957001552172803 0.05446368999917738 1.5282268217849575e-08 2.2611618076071233e-09 0.05273424344235 0.017578080361650057 1.191518558641003e-10 9.923899188858767 -0.5450586894542617 LAVEAVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAVEAVLR 8 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 39987200.0 12008000.0 19132000.0 8847200.0 False True 15742604.285637405 16277580.175951906 7931776.612334963 1.0 1.0339826804134675 0.5038414526859087 23.908170888613647 -6.89160403266218 1.0128190536469905 1.0273993416616025 0.4567805976013859 0.9819061733104099 0.032592393307078645 0.11785237165839693 0.2143100385150157 0.02446581906655638 0.06135824740459765 1.283500278780949e-07 6.89160403266218 -0.5706187440602166 LAVEAVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAVEAVLR 8 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 163029000.0 47060000.0 70953000.0 45016000.0 False True 71393460.54684281 58290882.791680776 36118567.86878632 1.0 0.8164736986440775 0.5059086307363982 26.089288597447542 -6.963176405135909 0.3880803017143516 1.0194865094721364 0.29177115585824176 0.9998704771257814 0.002320794439130738 0.07858536197214945 0.01707668518913249 0.004014415395063395 0.026145736421166733 1.0884878729933138e-07 6.963176405135909 -0.7277153536138946 LAVEAVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAVEAVLR 8 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 39441000.0 12008000.0 13289000.0 14144000.0 False True 16447682.103998378 12701848.039153613 10803478.504823774 1.0 0.7722576323423612 0.6568389659110376 23.97138095013654 -13.999999999999998 0.08756928665768393 2.179074092885916 0.355708900005621 0.9998536664455456 0.0017246920916849423 12.18584139763508 0.08537630178849022 2.6978504439772517 0.27117969367436073 1.0000000000000041e-14 13.999999999999998 -1.8233651928802947 LAVEAVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAVEAVLR 8 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 33901500.0 18245000.0 8139700.0 7516800.0 False True 15171525.890545623 8095849.820496044 9088528.126243638 1.0 0.5336213297794324 0.5990516835163757 23.85486285751011 -10.495509236899872 6.174407032117835 1.0003328292977014 0.5663365066479958 0.9832134327143462 0.026711830057553013 0.00012247450541706098 1.0006964968719609e-05 0.0258828853608629 0.008621206079968786 3.195146407321932e-11 10.495509236899872 -0.43399632264970556 LAVEAVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAVEAVLR 8 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 143336000.0 47060000.0 58064000.0 38212000.0 False True 60920097.69128401 54832687.35764185 31257808.08822997 1.0 0.9000754994765365 0.5130951733963175 25.86041491953999 -6.945618054727941 0.6050436964251831 1.0043149495776882 0.38887376375882055 0.9988109807575728 0.007240475411505747 0.08529451325680956 0.04362278396306995 0.007394729101457549 0.03257538605753297 1.1333967038034003e-07 6.945618054727941 -0.6154411858188676 LAVEETK(ub)GELLLQLCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAVEETKGELLLQLCR 16 1 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 11917500.0 2752400.0 4647900.0 4517200.0 True False 3563036.057915217 4389240.27916753 3695115.9503860665 1.0 1.2318820825337753 1.0370694796022164 21.764675652939154 -10.599730448216437 7.805109660980789 0.9998989593038339 1.1344757810679957 0.38849902919416957 0.07953191210762427 0.00013994055640825098 7.176588027864774e-06 0.07706405046632628 0.025668814257071727 2.5134459577313884e-11 10.599730448216437 0.13457682176416186 LAVEILNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAVEILNK 8 0 P19525-2;P19525;C9JZT2;F8WBH4 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 0 5228100.0 1638300.0 1561600.0 2028200.0 False True 2147827.1653197682 1328615.3670691252 1818341.3198681816 1.0 0.6185857915021393 0.8465957360202524 21.034446474301017 -10.290396767513768 5.662777735963561 1.000025636044531 0.7325907637611926 0.6471337690483343 0.09308467005829162 3.0130189211865134e-05 3.7757117470928743e-06 0.09013747432999601 0.030042948076912913 5.123930524302065e-11 10.290396767513768 -0.2674348722833384 LAVEILNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAVEILNK 8 0 P19525-2;P19525;C9JZT2;F8WBH4 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 0 5810800.0 1638300.0 1473700.0 2698800.0 False True 2244023.783392785 1408587.0611257937 2061399.0235307126 1.0 0.6277059412427984 0.9186172797215373 21.09765653582391 -9.832902341554735 6.0719768865835615 1.00000001858346 0.773161610481975 0.44772191881385137 0.11876405661118689 2.988637481574495e-08 5.644048318175916e-09 0.11499281191311204 0.03833093444849602 1.469256627654265e-10 9.832902341554735 -0.22683840810148514 LAVLITNSNVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAVLITNSNVR 11 0 P51570;P51570-2 P51570 GALK1 Galactokinase 0 23151200.0 6862300.0 7159600.0 9129300.0 False True 8996541.754607737 6091415.587902212 8184687.610429241 1.0 0.677084123439141 0.9097593090408667 23.100939109403072 -10.029497405397073 5.110443150186374 1.0000022666596171 0.7934217162389741 0.512435957313065 0.09498924675885066 131318343.47656901 41.38112950513746 3502.644572575715 0.03251734573085532 9.343349502323468e-11 10.029497405397073 -0.20658055042064305 LAVLITNSNVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAVLITNSNVR 11 0 P51570;P51570-2 P51570 GALK1 Galactokinase 0 20935500.0 8859900.0 4004200.0 8071400.0 False True 8578647.324164066 5603097.941627145 5957258.203190305 1.0 0.6531446893549888 0.6944286177157657 23.03231875171474 -10.418426138385378 9.066480855443002 1.0000017404976482 0.6737866536924998 0.9881304520720435 0.016854093176919754 5.929702008181215e-07 3.803235940958151e-08 0.01631899282437578 0.0054396351824698595 3.815696833296172e-11 10.418426138385378 -0.32621508680514844 LAVLITNSNVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAVLITNSNVR 11 0 P51570;P51570-2 P51570 GALK1 Galactokinase 0 24172500.0 9978500.0 0.0 14194000.0 False True 15138114.026066134 0.0 11388549.67854881 1.0 0.0 0.752309677344153 23.85168214333144 -10.767395788359767 9.540808050564353 1.003765690955385 0.3761548397649492 0.4783112139690122 0.30712913967517086 0.02458123061126467 0.0005992876043083046 0.2971374142627974 0.09912550359141237 1.7084576258253648e-11 10.767395788359767 -0.6276108511904357 LAVLITNSNVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAVLITNSNVR 11 0 P51570;P51570-2 P51570 GALK1 Galactokinase 0 25876900.0 6862300.0 5041600.0 13973000.0 False True 9399477.756684564 4818845.44165828 10672865.182968238 1.0 0.5126716149981092 1.135474274129548 23.164149170925963 -6.697963982251978 1.8381332697199098 0.6967884943328361 1.1335528895493723 0.4079369812628457 0.20578467580105714 0.39976318264833377 2.6244989540555665 0.08936269926276393 0.23039639380062144 2.0046382730009278e-07 6.697963982251978 0.4367643952165362 LAVLITNSNVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAVLITNSNVR 11 0 P51570;P51570-2 P51570 GALK1 Galactokinase 0 16104200.0 8859900.0 3236100.0 4008200.0 False True 7367399.410120324 3218666.4869844406 4846296.088177115 1.0 0.43687959723794495 0.6578028173034758 22.812724027149017 -10.21713894753856 5.480716770204907 1.000023180951687 0.5473412072706766 0.8484285672050589 0.09019152691565516 2.554800119282053e-05 3.6491853074576137e-06 0.08733203414565072 0.029109190142760304 6.065422423081701e-11 10.21713894753856 -0.4526819736810105 LAVLITNSNVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAVLITNSNVR 11 0 P51570;P51570-2 P51570 GALK1 Galactokinase 0 37677500.0 9978500.0 16165000.0 11534000.0 False True 12917364.955641277 15265403.539822988 9434930.348834002 1.0 1.1817738054351614 0.7304067339766208 23.62280846542389 -6.79736514156385 1.466430495268754 1.1006269346622735 0.7245573134608517 0.8244391849981466 0.07769461601965535 0.22452039706164964 0.9534080561599628 0.04168484638488061 0.09711259668436602 1.5945379445894968e-07 6.79736514156385 -0.37606962120142173 LAVLK(ub)YYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAVLKYYK 8 1 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 7113800.0 2157500.0 2215000.0 2741300.0 True False 2828503.39325972 1884530.6340023768 2457656.572406396 1.0 0.6662642295191105 0.8688893844932106 21.431607471059277 -10.32357350638933 5.657827824642217 1.0000346078664586 0.7675768070061586 0.6369351122296626 0.08272137312315846 3.6116741904577755e-05 4.317897245239954e-06 0.08010653554700663 0.026698208373449196 4.7470793758439026e-11 10.32357350638933 -0.2324578008603 LAVLK(ub)YYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAVLKYYK 8 1 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 9163700.0 2761000.0 3367300.0 3035400.0 True False 2673353.5662949886 4711880.450237517 2240337.6799519155 1.0 1.7625354572039384 0.838025208561099 21.35021922419206 -6.687603594752419 1.874751996457593 1.4791269628894066 0.8412948393871941 0.359301219684948 0.32265697903019713 0.42184682775164223 2.8726672080909723 0.13777408001281674 0.35988450680969136 2.0530352457779e-07 6.687603594752419 -0.6378321235022125 LAVLK(ub)YYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAVLKYYK 8 1 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 26618600.0 3912000.0 6713600.0 15993000.0 True False 5934790.005508918 5515505.626403786 12831976.540019082 1.0 0.9293514380936925 2.162161850395365 22.50076555228812 -6.893314328158972 1.0025537786927292 0.9389263299466621 2.275351499653871 0.9829368014454056 0.07383471193786056 0.11649583292685536 0.20646146643955152 0.055855659553239734 0.14101992149681924 1.278455664777103e-07 6.893314328158972 1.3364251697072087 up LAVLK(ub)YYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAVLKYYK 8 1 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 7543200.0 2157500.0 3102000.0 2283700.0 True False 2955186.0542452135 2964943.3830577577 1744337.0942778585 1.0 1.0033017646379752 0.5902630366612843 21.494817532582168 -6.905096528361218 0.9284702386458664 1.0148549359002144 0.5421235287230792 0.9889361355304109 0.020399010258097604 0.10775091195208861 0.1570122203384515 0.016306180426644966 0.043621283315773494 1.244238030761169e-07 6.905096528361218 -0.47273140717713513 LAVLK(ub)YYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAVLKYYK 8 1 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 13734900.0 2761000.0 8373000.0 2600900.0 True False 2295893.833038996 8327892.987089634 3144736.1647971356 1.0 3.627298818110543 1.3697219442566977 21.130624499626336 -6.609240753297889 2.1561647200197402 2.756150347676408 1.3776706896437234 0.048159353112419145 1.1329206394122278 0.6147216863692813 5.414296207284502 0.4340283041551117 1.258171887311839 2.4590040651528375e-07 6.609240753297889 -1.3784796580326846 LAVLK(ub)YYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAVLKYYK 8 1 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 24863000.0 3912000.0 12974000.0 7977000.0 True False 5064161.117048523 12251985.494937414 6525267.850931921 1.0 2.419351440792641 1.2885190064282463 22.271891874380568 -6.589430213611731 2.2314285372625493 1.960984514084657 1.2917968038320469 0.0 0.6151409720251241 0.6711160075338451 6.299266896101506 0.23023329915434732 0.6855984118460502 2.573770308026757e-07 6.589430213611731 -0.66918771025261 LAVTASIHVYSIQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAVTASIHVYSIQK 14 0 Q15054;Q15054-2;E9PM91;E9PNC0;E9PRK3 Q15054 POLD3 DNA polymerase delta subunit 3 0 13336500.0 2570800.0 4175400.0 6590300.0 False True 3900091.550654989 3430267.2474508975 5287724.316368903 1.0 0.8795350578051973 1.3557949211425235 21.89507655948514 -6.839666160875371 1.2839648005939346 0.9359130534304942 1.3713544180523756 0.9238770432527432 0.05578486486040667 0.16918769498252156 0.5419469622796707 0.034070542231245726 0.0784841435674868 1.4465512973244237e-07 6.839666160875371 0.4354413646218813 LAVTASIHVYSIQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAVTASIHVYSIQK 14 0 Q15054;Q15054-2;E9PM91;E9PNC0;E9PRK3 Q15054 POLD3 DNA polymerase delta subunit 3 0 10585400.0 2570800.0 4295100.0 3719500.0 False True 3327951.2780440534 4056073.9093036596 3042589.165292878 1.0 1.2187900514239343 0.9142529175129956 21.66620288157759 -6.713912597036242 1.7815188814672358 1.133967207462563 0.9148904029895778 0.48357744844165396 0.0921425297328353 0.3672478003462008 2.2744690351507217 0.041125164648605474 0.10397437302847601 1.9323571701032888e-07 6.713912597036242 -0.21907680447298528 LAVVDPLFGMQPIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAVVDPLFGMQPIR 14 0 P08243-2;P08243;F8WEJ5;C9J057;C9JT45;C9JM09;C9JLN6 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 4035100.0 449000.0 2270900.0 1315200.0 False True 588643.3481221849 1932090.5718988674 1179115.7202892376 1.0 3.282277083504599 2.0031071854471856 19.167034261734106 -10.217795064478956 5.898882682031761 0.9999600588107491 2.6426921344759076 0.6873871731333059 0.5222189240948284 0.0002743189211478885 3.637762368895103e-05 0.5056484443163705 0.16854543300779393 6.056265913061152e-11 10.217795064478956 1.6427320756651584 LAVVK(ub)FTMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAVVKFTMR 9 1 O43396;K7ER96;K7EPB7 O43396 TXNL1 Thioredoxin-like protein 1 1 10273100.0 1836700.0 2978900.0 5457500.0 True False 1778394.96385875 4168390.3047582842 4028017.028509449 1.0 2.343905819275229 2.264973254180547 20.762144337316844 -10.15915100822991 5.220133851972662 0.9999467844067956 2.304439536728172 0.9972613609540583 0.03222408476468462 1.9960031660080416e-05 3.2150446334642293e-06 0.031202095838690148 0.010400278636289098 6.931847373289142e-11 10.15915100822991 1.3044927523213765 LAVVK(ub)FTMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAVVKFTMR 9 1 O43396;K7ER96;K7EPB7 O43396 TXNL1 Thioredoxin-like protein 1 1 60422100.0 3487100.0 11609000.0 45326000.0 True False 5290185.641158012 9537283.248468997 36367296.232908435 1.0 1.8028258165967317 6.874483940595268 22.334886919050774 -6.934754193811143 0.7066768022107672 0.934776563806489 8.054061619090659 0.9973929290388028 0.1327937198714116 0.09024327308588202 0.06612990571112201 0.12460692061036839 0.4475107979115483 1.1621061678204562e-07 6.934754193811143 7.11928505528417 LAVVK(ub)FTMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAVVKFTMR 9 1 O43396;K7ER96;K7EPB7 O43396 TXNL1 Thioredoxin-like protein 1 1 8935900.0 1836700.0 3646100.0 3453100.0 True False 1527297.429606203 3626457.735605812 4175127.2446695287 1.0 2.3744279701569684 2.7336700525620867 20.54254961275112 -10.15533246479569 0.3116648122618038 2.538087387345325e-24 2.8423825942165837 0.9989360794116249 0.02436946573706193 1.5869732950453568 0.14317805158080368 1.4862768330579914 0.12219586360219288 6.993064520343185e-11 10.15533246479569 2.8423825942165837 LAVVK(ub)FTMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAVVKFTMR 9 1 O43396;K7ER96;K7EPB7 O43396 TXNL1 Thioredoxin-like protein 1 1 35084100.0 3487100.0 12109000.0 19488000.0 True False 4514119.691017357 11435123.505333517 15941383.963765966 1.0 2.533190142939333 3.531449109665327 22.106013241143224 -8.321872856162152 0.20908564395807963 3.0009410070017055e-14 4.659600676346332 0.9996983477716519 0.01808236146770988 0.10229935553814742 0.048768210145312636 0.4443607553305716 0.437756195018172 4.765704869246074e-09 8.321872856162152 4.659600676346302 LAVYCLK(ub)DAYLPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAVYCLKDAYLPLR 14 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 5636900.0 1497000.0 2103700.0 2036200.0 True False 1962581.4969686212 1789836.1601583743 1825513.5566096029 1.0 0.9119805536345538 0.9301593637916531 20.904321133051376 -10.177511614291461 4.71432641701407 1.0000104655873185 0.9210699587125937 0.9617382640330898 0.007421468171051624 8.16456228669167e-07 1.4243738646182006e-07 0.007186758401040287 0.0023952685523265385 6.644899022868854e-11 10.177511614291461 -0.07894050687472487 LAVYCLK(ub)DAYLPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAVYCLKDAYLPLR 14 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 54357000.0 3814000.0 10279000.0 40264000.0 True False 5786116.840749227 8444632.139806436 32305802.751661893 1.0 1.459464503090291 5.5833305204183725 22.46416402564864 -6.928020999702701 0.7628604513648242 0.9324677146287039 6.388798268471862 0.9961347809635643 0.12812549445413643 0.09367869241950824 0.08281021495383352 0.11538248260469346 0.37728145646762606 1.1802635642768268e-07 6.928020999702701 5.456330553843158 up LAVYCLK(ub)DAYLPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAVYCLKDAYLPLR 14 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 5552700.0 1497000.0 1377300.0 2678400.0 True False 2050481.3549038626 1316446.3318779657 2045817.083379527 1.0 0.6420181918404655 0.9977252797187448 20.967531194574267 -10.939901450374592 10.233383565131994 1.043708948011298 0.8198717357796051 0.25479599884239124 0.14521681053218663 0.08750735130114763 0.0005139120325265817 0.08496473988492848 0.04686852406504304 1.1484141888145562e-11 10.939901450374592 -0.22383721223169284 LAVYCLK(ub)DAYLPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAVYCLKDAYLPLR 14 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 84305200.0 3814000.0 5956200.0 74535000.0 True False 4937298.185179713 5624732.234079407 60970394.79368322 1.0 1.139232840131707 12.34893913774502 22.23529034774109 -6.909610816533306 0.8983876897950106 0.6486426199494445 13.785579137499008 0.9907737764565064 0.510756105526869 0.10467558767660066 0.14016965382215055 0.41736050651497847 1.1490111560826304 1.2313717432940084e-07 6.909610816533306 13.136936517549563 up LAVYIDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAVYIDK 7 0 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 0 20020500.0 6819800.0 4632000.0 8568700.0 False True 8940823.843037155 3940923.6553945825 7682093.120774326 1.0 0.4407785819942818 0.8592153537122768 23.091976342511675 -9.795236246030864 6.198330718657281 1.0000000119274501 0.6499969678529912 0.48263551514573066 0.17082609672215457 2.8055625390276644e-08 5.368080550980531e-09 0.16540166308684812 0.05513388564172033 1.6023734998967592e-10 9.795236246030864 -0.3500030440744589 LAVYIDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAVYIDK 7 0 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 0 12222700.0 4946600.0 3131300.0 4144800.0 False True 4789572.890631939 4381644.419513785 3059152.538665314 1.0 0.9148298855799788 0.6387109265314235 22.191465578930586 -6.9496948286485525 0.5621822294569193 1.0035708623508675 0.5367242158259421 0.9991771279255928 0.004423613953314908 0.08360848052589659 0.036471039161064464 0.004729460857577069 0.02296401724017883 1.1228071546714273e-07 6.9496948286485525 -0.46684664652492536 LAVYIDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAVYIDK 7 0 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 0 28294300.0 4105500.0 17082000.0 7106800.0 False True 6228343.6522537945 14033583.637724819 5702137.864978901 1.0 2.2531806883595147 0.9155143298677041 22.570417117421997 -6.6608173953197545 1.969585053361798 1.8060842693587034 0.9210325249442269 0.23929043051261645 0.5334657970603728 0.48248283408184883 3.5987592528343435 0.21874004903486385 0.5915797312477027 2.1836478615736835e-07 6.6608173953197545 -0.8850517444144764 LAVYIDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAVYIDK 7 0 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 0 21083700.0 6819800.0 7504700.0 6759200.0 False True 9341264.358165251 7173117.539275807 5162816.170093666 1.0 0.7678957862921142 0.552689226226728 23.155186404034566 -6.9720332408531895 0.2038548098671737 1.1218943420352616 0.1927238028497359 0.9999941987647755 0.0004399059523272907 0.07564830682610182 0.006613731093781888 0.006770351352155356 0.022628875095205336 1.0665144872013996e-07 6.9720332408531895 -0.9291705391855257 LAVYIDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAVYIDK 7 0 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 0 9480200.0 4946600.0 2765700.0 1767900.0 False True 4113317.0715359263 2750800.6251515322 2137559.716153965 1.0 0.6687548217926157 0.5196681118861067 21.971870854364862 -13.999999999999998 0.10780397732233847 2.6048630527750745 0.23732029694804835 0.9997542251196794 0.0031470376702364255 12.026002395203285 0.09926705293473363 4.218639723091082 0.250940324421737 1.0000000000000041e-14 13.999999999999998 -2.367542755827026 LAVYIDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAVYIDK 7 0 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 0 18519300.0 4105500.0 8425200.0 5988600.0 False True 5314650.681503757 7956330.213653972 4898736.248225008 1.0 1.4970560984081016 0.9217419058742224 22.341543439514446 -6.678256961395744 1.9091993993450638 1.3150035632167996 0.9240181113459834 0.3157326353303749 0.21074793781584328 0.4423700305511333 3.116309856695519 0.08864718163691711 0.23422845933702946 2.0976983596876835e-07 6.678256961395744 -0.3909854518708161 LAVYIDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAVYIDR 7 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 43839000.0 10679000.0 15226000.0 17934000.0 False True 14000272.415583123 12954340.150483156 16078361.715075439 1.0 0.9252920061801239 1.1484320617346904 23.738951563438007 -6.816413852002432 1.3872281383204674 0.9595809167256264 1.152942338105626 0.8759585356216837 0.03266226185586559 0.1981807165485342 0.7503212622953758 0.018506318787286615 0.0427020856675609 1.5261110889037238e-07 6.816413852002432 0.19336142137999968 LAVYIDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAVYIDR 7 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 22804700.0 10210000.0 3865100.0 8729600.0 False True 9885889.13867144 5408454.586230224 6443055.877613565 1.0 0.5470883306867695 0.6517426796149005 23.236939297369155 -9.804397197923375 6.253902211571673 1.0000000133509175 0.5994155051506135 0.9513025498246924 0.042724959040367466 7.984914209899308e-09 1.4785213663946877e-09 0.04136826494017843 0.013789421235769895 1.5689272353248882e-10 9.804397197923375 -0.400584508200304 LAVYIDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAVYIDR 7 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 48319000.0 10189000.0 27995000.0 10135000.0 False True 15457457.91567749 22999073.52406666 8131812.807671698 1.0 1.4878949468618772 0.5260769818706174 23.881799741947916 -6.768771584586425 1.5789114972007858 1.2802749157484534 0.5208827190381016 0.7259590980779664 0.20556076589018957 0.2684034005193448 1.3203047824730703 0.10262687404752645 0.24459519324520468 1.7030539871944435e-07 6.768771584586425 -0.7593921967103519 LAVYIDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAVYIDR 7 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 36251000.0 10679000.0 9470000.0 16102000.0 False True 14627314.889123833 9051584.086897785 12299039.231099574 1.0 0.6188137847246392 0.8408268588136123 23.8021616249609 -10.223058415320745 5.502750245511361 1.0000143330027529 0.7298203217691074 0.663824385393611 0.09063645795751472 1.593840580394082e-05 2.2502625302114195e-06 0.08776302571678911 0.029252791019047583 5.983311103756245e-11 10.223058415320745 -0.2701940112336455 LAVYIDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAVYIDR 7 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 20297200.0 10210000.0 7091000.0 2996200.0 False True 8490067.379691472 7052799.375546697 3622691.567136438 1.0 0.8307118259646833 0.42669762265986705 23.01734457280343 -6.9564492630015495 0.4828838368729346 1.0094391289502511 0.23104362396051029 0.9996149906447562 0.004719001515204732 0.08099479251565206 0.026010015195672715 0.005730225423632405 0.03332484230101703 1.1054796108834876e-07 6.9564492630015495 -0.7783955049897409 down LAVYIDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAVYIDR 7 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 47672000.0 10189000.0 23448000.0 14035000.0 False True 13189861.355216611 22143098.187551435 11480774.011261065 1.0 1.678796887337546 0.8704241615640941 23.652926064040365 -6.684012342984468 1.8877878157793733 1.4279270629977525 0.8734083459510121 0.3425393716526608 0.28744123184653647 0.42965424316204864 2.9637649660550016 0.12202957469375128 0.3201815480349331 2.070082514611742e-07 6.684012342984468 -0.5545187170467404 LAYAIIQFLHDQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAYAIIQFLHDQLR 14 0 O43765;K7EMD6;K7ERW5 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 0 174291000.0 122730000.0 15589000.0 35972000.0 False True 118834003.3290055 21813768.99556104 26549854.06313179 1.0 0.18356504354369962 0.22341967214237066 26.824372469100556 -10.441558844572908 6.093611146710861 1.0003149681920394 0.20349235784303502 0.998125764227782 0.016270583992480065 6.964813424574434e-05 6.382820277334999e-06 0.015759844483936334 0.005251308402995289 3.617771685454798e-11 10.441558844572908 -0.7968226103490044 LAYAIIQFLHDQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAYAIIQFLHDQLR 14 0 O43765;K7EMD6;K7ERW5 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 0 1245074500.0 256687500.0 385972500.0 602414500.0 False True 389413703.8699053 317092691.7580935 483347010.0273454 1.0 0.814282313659992 1.241217258724981 28.536728413977027 -6.788449779925003 1.5023223429048633 0.8959953411237593 1.2455796108844335 0.7963468007017475 0.07887719171210734 0.2376562920470469 1.0596383261668834 0.041328680492168125 0.09687921083780907 1.6276095150081749e-07 6.788449779925003 0.34958426976067414 LAYAIIQFLHDQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAYAIIQFLHDQLR 14 0 O43765;K7EMD6;K7ERW5 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 0 221570000.0 122730000.0 59076000.0 39764000.0 False True 102055432.8608751 58757745.86233213 48078468.55203703 1.0 0.5757434387881376 0.47110151027019775 26.604777744534832 -13.999999999999998 0.1965944603941138 3.3284922145608133 0.4008155730865347 0.9994871120055994 0.005179064401151352 12.465610501027887 0.14060297050203197 11.14584098142897 0.06836296865460426 1.0000000000000041e-14 13.999999999999998 -2.9276766414742785 LAYAIIQFLHDQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAYAIIQFLHDQLR 14 0 O43765;K7EMD6;K7ERW5 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 0 676937900.0 256687500.0 246749300.0 173501100.0 False True 332287028.81707364 233017484.54493302 141925680.07162154 1.0 0.7012536281493275 0.4271177258314005 28.307854736069476 -7.079928320553744 0.21007846743726308 1.1500886130387822 1.1756610033776476e-10 0.99999262059614 0.000635500675442963 0.07454131354937692 0.007403474747549742 0.009296206599416193 0.02912075156046592 8.319010633994773e-08 7.079928320553744 -1.150088612921216 down LAYFNDIAVGAVCCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAYFNDIAVGAVCCR 15 0 E7EQ69;Q9GZZ1 E7EQ69 NAA50 N-alpha-acetyltransferase 50 0 8354800.0 1821600.0 4446300.0 2086900.0 False True 2388135.2403994943 3782929.3715416524 1870967.606958343 1.0 1.5840515677448956 0.783442903612679 21.18745310824222 -6.711109343123066 1.7912626291607223 1.3586519123242426 0.7852617754692294 0.47038346297217726 0.24607333279011737 0.37284034695452084 2.332672992535349 0.10929357087452468 0.277282905758064 1.944870356377447e-07 6.711109343123066 -0.5733901368550133 LAYFNDIAVGAVCCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAYFNDIAVGAVCCR 15 0 E7EQ69;Q9GZZ1 E7EQ69 NAA50 N-alpha-acetyltransferase 50 0 8481500.0 1821600.0 2841600.0 3818300.0 False True 2495094.7468890306 2716048.7160854023 2916496.1803569444 1.0 1.088555342225727 1.1688919565051914 21.25066316976511 -6.972284864808538 0.19607011904202123 0.9496883612445126 1.3099676971842618 0.999995144210288 0.0001518871689881429 0.07556799747396525 0.0063005355048941615 0.002694617557649899 0.008615465607231261 1.065896743072083e-07 6.972284864808538 0.36027933593974915 LAYHPLK(ub)MQSCYEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAYHPLKMQSCYEK 14 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 10799600.0 1873500.0 3858900.0 5067200.0 True False 2456176.642999811 3283167.1618743916 4542894.752014622 1.0 1.3366983076040284 1.8495798194979298 21.227982889322075 -6.965000431470269 0.35804987392010384 0.9548086699132969 2.2489920467160815 0.9999131482550231 0.003255426327737626 0.07796087056109342 0.014859767704979076 0.006909000649251183 0.043858187420083385 1.0839258371435906e-07 6.965000431470269 1.2941833768027846 LAYHPLK(ub)MQSCYEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAYHPLKMQSCYEK 14 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 7527800.0 1679100.0 2516200.0 3332500.0 True False 1625797.889592872 3520931.7818096527 2459618.277142965 1.0 2.1656638899262903 1.5128684154946812 20.632716489833438 -10.063082684726721 5.304187655621687 0.9999909985141757 1.8392661527116019 0.68787644013147 0.2665026364631579 2.8369186465147158e-05 5.010734715292106e-06 0.25804282962341163 0.08601335606128448 8.648032544036229e-11 10.063082684726721 0.8392751541974262 LAYHPLK(ub)MQSCYEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAYHPLKMQSCYEK 14 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 21195000.0 7202600.0 5011500.0 8980900.0 True False 10926870.780592654 4117158.6699717804 7205821.178531701 1.0 0.37679210751575054 0.6594588078528435 23.38137696772016 -10.44769396619282 6.139202611947585 1.0001959816174273 0.5181254576843431 0.7948664245350775 0.11539819718367944 0.0003096715531610795 2.7859142826084532e-05 0.11177840323798251 0.03724460798956245 3.567024019682179e-11 10.44769396619282 -0.48207052393308414 LAYHPLK(ub)MQSCYEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAYHPLKMQSCYEK 14 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 8934500.0 1873500.0 3507100.0 3553900.0 True False 2566183.5794337955 3352144.7255711975 2714542.014868018 1.0 1.3062762744007648 1.0578128691272184 21.291192950844966 -10.762491199849327 8.264651197672617 0.9980173304169706 1.1820445717639916 0.41716897264683817 0.10143476044575528 0.003740696750324279 0.00010749974306895646 0.0991428280018465 0.03273792816107908 1.7278609919658742e-11 10.762491199849327 0.18402724134702098 LAYHPLK(ub)MQSCYEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAYHPLKMQSCYEK 14 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 7940800.0 1679100.0 1988400.0 4273300.0 True False 1396246.0467424055 1977688.0945335005 5166827.272493205 1.0 1.4164323681686783 3.7005134478611255 20.413121765267714 -6.937763233458512 0.6800517581436859 0.9730998665815707 4.277940370946168 0.9978560410391774 0.054966952226308145 0.08880199999511745 0.05936812824184268 0.05263955102783613 0.19860127009068707 1.1540822632700703e-07 6.937763233458512 3.3048405043645976 up LAYIAHPKLGK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LAYIAHPKLGK 11 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 20584600.0 5470800.0 6042900.0 9070900.0 True False 5297132.448564524 8455861.483307205 6694959.168833038 1.0 1.596309241917987 1.263883664197846 22.336780151302552 -10.065932563007884 4.639322725927279 0.9999800423198526 1.4300964530712645 0.6905878615067949 0.13571217385641654 2.8016996311974017e-05 5.640878273281679e-06 0.13140883874832704 0.04380091581287945 8.591469189772429e-11 10.065932563007884 0.43011641075141194 LAYMELQQK(ub)AEFSDQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAYMELQQKAEFSDQK 16 1 P49454 P49454 CENPF Centromere protein F 1 33319100.0 3562100.0 12203000.0 17554000.0 True False 5403966.124392464 10025279.307525825 14084444.205808474 1.0 1.8551706425903822 2.6063161540250968 22.365587200256428 -6.972649718632817 0.18421076801243041 0.45074628047092347 4.031138966725015 0.9999963528822403 0.0012532249610428163 0.07545192943039862 0.00583725377139059 0.027875755586323447 0.08324342635466432 1.0650016518204134e-07 6.972649718632817 3.5803926862540916 LAYMELQQK(ub)AEFSDQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAYMELQQKAEFSDQK 16 1 P49454 P49454 CENPF Centromere protein F 1 31738100.0 3562100.0 11256000.0 16920000.0 True False 4611208.669488381 10629593.70518078 13840733.613860855 1.0 2.305164321778599 3.001541375787815 22.136713522348877 -9.036102658316302 0.21386269052813558 2.7002277121027897e-22 3.6487371975974465 0.9994636464721539 0.019213638976667554 0.500540945792439 0.07253939366665844 0.7054399322122237 0.3513480701534844 9.202320220486936e-10 9.036102658316302 3.6487371975974465 LAYMPHTFFIGDHANMFPHLKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LAYMPHTFFIGDHANMFPHLKK 22 1 O15294;O15294-3;O15294-2;O15294-4 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 20192900.0 5943700.0 11852000.0 2397200.0 True False 7792248.258872681 10083727.798734168 2149160.7395661203 1.0 1.2940716804360388 0.27580752924792507 22.893608211341316 -6.829462796432377 1.3303408964013343 1.157190466659319 0.2487119087403743 0.9047914671866969 0.13202866780964773 0.18147396423027434 0.6283274956327918 0.07792777861591156 0.17933480067696525 1.4809391135651121e-07 6.829462796432377 -0.9084785579189446 down LAYMPHTFFIGDHANMFPHLKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 2 LAYMPHTFFIGDHANMFPHLKK 22 1 O15294;O15294-3;O15294-2;O15294-4 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 164143000.0 49953000.0 54378000.0 59812000.0 True False 48367269.35788979 76091418.97752386 44145442.87846205 1.0 1.5732006372840985 0.912713152189993 25.52752775491999 -6.677184104721428 1.9114900158591646 1.3635687975814865 0.9152522009113975 0.31150290190411745 0.24308436731821648 0.4447827229596121 3.139446319317521 0.10212549693754149 0.27036449439484805 2.1028868017730058e-07 6.677184104721428 -0.44831659667008905 LAYMPHTFFIGDHANMFPHLKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 2 LAYMPHTFFIGDHANMFPHLKK 22 1 O15294;O15294-3;O15294-2;O15294-4 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 1235472700.0 378500000.0 293437000.0 563535700.0 True False 574212172.056524 241070874.7162547 452152621.8885287 1.0 0.41982891768536784 0.7874312734771145 29.0970086719837 -10.1310311943359 5.318998132196477 1.0000094636183494 0.6036300955810548 0.6078715736013833 0.15007303332321761 1.6842311947967284e-05 2.7515774835681175e-06 0.14531105647736767 0.04843586323119637 7.395521528847361e-11 10.1310311943359 -0.39637936803729457 LAYMPHTFFIGDHANMFPHLKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LAYMPHTFFIGDHANMFPHLKK 22 1 O15294;O15294-3;O15294-2;O15294-4 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 71975700.0 5943700.0 40992000.0 25040000.0 True False 8141246.512452972 39180837.897583336 19126067.714987803 1.0 4.812633770228151 2.349280013291857 22.956818272864208 -9.82952157921341 7.8199363431123325 0.9996047276312267 3.580956891760378 0.5941034041274842 1.0056599859702284 2.9522595301601436e-08 7.421875904834629e-09 0.9737260827026535 0.32457536090088474 1.4807386785329747e-10 9.82952157921341 2.5813521641291515 LAYMPHTFFIGDHANMFPHLKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LAYMPHTFFIGDHANMFPHLKK 22 1 O15294;O15294-3;O15294-2;O15294-4 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 82347000.0 24884000.0 30621000.0 26842000.0 True False 20692148.548113883 30456038.595207352 32454538.096614495 1.0 1.4718644863963855 1.5684469895018596 24.302580117953507 -11.822729769090552 0.2651810522448782 1.156395264754538e-09 1.6057582931054633 0.9993704152247482 0.006231572315971314 4.712013829335788 0.14977743414047304 2.6616638104218717 0.04101727301999388 1.5040775566560837e-12 11.822729769090552 1.605758291949068 LAYMPHTFFIGDHANMFPHLKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LAYMPHTFFIGDHANMFPHLKK 22 1 O15294;O15294-3;O15294-2;O15294-4 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 1616028000.0 378500000.0 403797900.0 833730100.0 True False 489975711.3504251 381326191.8981183 681999776.5932374 1.0 0.7782552952413556 1.3919052736585116 28.86813499407615 -6.80896287606257 1.4189948328886588 0.8790035158159033 1.4023774174164163 0.857078742888787 0.09591553439735988 0.20821699807949892 0.8265255868661847 0.053153858408968725 0.12300853000713804 1.5525197152625765e-07 6.80896287606257 0.523373901600513 LAYSPTMGLYLGIYMHAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LAYSPTMGLYLGIYMHAPK 19 0 Q12769;G3V198;E9PR16;Q12769-3 Q12769 NUP160 Nuclear pore complex protein Nup160 0 45148000.0 12261000.0 13961000.0 18926000.0 False True 18600833.399167888 11469550.472209118 15185267.80443952 1.0 0.6166148702091064 0.8163756686901371 24.1488639260777 -10.109620500207148 4.855541493728952 1.0000134674580994 0.7164952694477059 0.7286726170909684 0.08155200448818631 1.18899741917464e-05 2.1803065547226067e-06 0.07896613819294492 0.026320796268440378 7.769257215355016e-11 10.109620500207148 -0.28351819801039346 LAYSPTMGLYLGIYMHAPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LAYSPTMGLYLGIYMHAPK 19 0 Q12769;G3V198;E9PR16;Q12769-3 Q12769 NUP160 Nuclear pore complex protein Nup160 0 32610600.0 12261000.0 9526600.0 10823000.0 False True 15872106.20044271 8996436.335445566 8853325.053357935 1.0 0.5668079725420836 0.557791445039033 23.919990248170148 LCAAAASILGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCAAAASILGK 11 0 P30046;B5MC82;P30046-2;A6NHG4;J3KQ18 P30046 DDT;DDTL D-dopachrome decarboxylase;D-dopachrome decarboxylase-like protein 0 20076600.0 7105100.0 7850100.0 5121400.0 False True 9314854.905886285 6678895.679450137 4591486.6559377285 1.0 0.7170155356074928 0.4929208991796808 23.15110186632913 -7.191565500276999 0.1568426712206125 1.2526847857801857 4.802417769165284e-12 0.9999961105946228 0.0004091405459840052 0.0901029699558699 0.006960090228572431 0.0166804213220367 0.03637798753387482 6.43331030513919e-08 7.191565500276999 -1.2526847857753833 down LCAAAASILGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LCAAAASILGK 11 0 P30046;B5MC82;P30046-2;A6NHG4;J3KQ18 P30046 DDT;DDTL D-dopachrome decarboxylase;D-dopachrome decarboxylase-like protein 0 9405900.0 5008700.0 1749600.0 2647600.0 False True 4849701.560123768 2448224.4040434672 1954114.1337025366 1.0 0.504819600483001 0.4029349248560083 22.209464539102918 -13.999999999999998 0.2222459194884009 4.017892970343011 0.3495957172837846 0.9995002423635191 0.005829872936364183 13.061674390737034 0.1493278321056622 17.320662011218236 0.055561809348568664 1.0000000000000041e-14 13.999999999999998 -3.6682972530592264 LCAAAASILGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCAAAASILGK 11 0 P30046;B5MC82;P30046-2;A6NHG4;J3KQ18 P30046 DDT;DDTL D-dopachrome decarboxylase;D-dopachrome decarboxylase-like protein 0 15540300.0 7105100.0 4706600.0 3728600.0 False True 9732047.478107851 4498646.849355134 2847981.4729274535 1.0 0.4622508120182107 0.29263949639928916 23.214311927852023 -13.999999999999998 0.16150626478457367 3.6569448663701345 0.12864358474508356 0.9995324869921556 0.006519765627334705 12.02004285055189 0.1270486459292428 10.003392469917992 0.14975500736007236 1.0000000000000041e-14 13.999999999999998 -3.5283012816250507 LCAAAASILGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LCAAAASILGK 11 0 P30046;B5MC82;P30046-2;A6NHG4;J3KQ18 P30046 DDT;DDTL D-dopachrome decarboxylase;D-dopachrome decarboxylase-like protein 0 8735400.0 5008700.0 1667500.0 2059200.0 False True 4164955.9730323902 1658516.846527166 2489769.1993349446 1.0 0.3982075338288979 0.597790040388401 21.989869814537194 -10.197023511169293 5.410487512077947 1.0000227096280156 0.4979987871085738 0.8940156372112609 0.08147921710967573 2.2321060109816127e-05 3.3127059356479845e-06 0.07889547543130417 0.026297304243944233 6.352965382101078e-11 10.197023511169293 -0.5020239225194418 LCAAAASILGKPADR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCAAAASILGKPADR 15 1 P30046;B5MC82;P30046-2;A6NHG4;J3KQ18 P30046 DDT;DDTL D-dopachrome decarboxylase;D-dopachrome decarboxylase-like protein 0 22028000.0 11261000.0 10767000.0 0.0 False True 15424496.017082434 10291278.338292336 0.0 1.0 0.6672035395448173 0.0 23.87872001546407 -7.496657646280348 0.7167921839526201 0.9929873416633805 4.704254404437272e-17 0.9870952060763133 0.0472331684858263 0.11884699383049457 0.1422437946934698 0.04168033804275392 0.07546897869069344 3.186708609697055e-08 7.496657646280348 -0.9929873416633805 down LCEGFNEVLK(ub)QCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCEGFNEVLKQCR 13 1 Q9Y6H1 Q9Y6H1 CHCHD2 Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 1 19311800.0 7677300.0 6777600.0 4856900.0 True False 10065014.647078952 5766408.498877883 4354354.578674579 1.0 0.5729160563667335 0.4326227761564451 23.262845935949457 -13.999999999999998 0.1556227852696284 3.085052540837205 0.28782288948369755 0.9995485702504973 0.005126714398252884 11.98334344303827 0.12450220048842017 7.545868071305274 0.13128516176870555 1.0000000000000041e-14 13.999999999999998 -2.7972296513535073 LCEGFNEVLK(ub)QCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCEGFNEVLKQCR 13 1 Q9Y6H1 Q9Y6H1 CHCHD2 Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 1 35201000.0 12591000.0 10618000.0 11992000.0 True False 19101467.525399476 8723134.941187339 9621775.943719681 1.0 0.4566735477045452 0.5037192001570286 24.18718014594295 -10.100328166780372 7.885264720093774 1.000000041849568 0.48019637516070196 0.9938939307756939 0.019206307187483434 1.4129325466709564e-08 1.6165578169535642e-09 0.018596428355347784 0.006198808989938944 7.937282416575701e-11 10.100328166780372 -0.5198036666888661 LCEGFNEVLK(ub)QCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCEGFNEVLKQCR 13 1 Q9Y6H1 Q9Y6H1 CHCHD2 Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 1 18250300.0 7677300.0 5492500.0 5080500.0 True False 10515805.28123141 5249823.188731377 3880590.536181927 1.0 0.49923168490969033 0.3690245713381549 23.32605599747235 -13.999999999999998 0.18911081924165118 3.6762251446706684 0.274772382889935 0.9994899210144372 0.0061430829710540985 12.336401372908682 0.13790481007741617 12.162069300526065 0.09018257279545151 1.0000000000000041e-14 13.999999999999998 -3.4014527617807335 LCEGFNEVLK(ub)QCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCEGFNEVLKQCR 13 1 Q9Y6H1 Q9Y6H1 CHCHD2 Coiled-coil-helix-coiled-coil-helix domain-containing protein 2 1 32546500.0 12591000.0 9064500.0 10891000.0 True False 16299297.705715215 8560052.60666412 8908949.751096847 1.0 0.5251792292659706 0.5465848843274392 23.9583064680354 -10.084927333449917 4.910405203826532 1.0000149022122105 0.5358820567935562 0.9984071698310981 0.008738822096061622 1.425728031533601e-06 2.6566948243048104e-07 0.008461599572970636 0.0028204427020630638 8.223802398501095e-11 10.084927333449917 -0.4641328454186543 LCEK(ub)MAQFDAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LCEKMAQFDAK 11 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 76954500.0 22976700.0 26754700.0 27223100.0 True False 30122676.20667928 22763003.04900375 24406314.75441453 1.0 0.7556766501362975 0.8102306244955344 24.844346614121417 -10.79525731541927 7.0709600682959834 1.0077415006794535 0.782953637316102 0.9547619216403895 0.02227156677016789 0.0027711120333516674 8.023864266199948e-05 0.021985397044690703 0.007188117266233889 1.6022957641388364e-11 10.79525731541927 -0.22478786336335144 LCEK(ub)MAQFDAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LCEKMAQFDAK 11 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 67862180.0 27135980.0 19815000.0 20911200.0 True False 26274563.16838445 27727232.833859883 15433929.397446934 1.0 1.0552880615432416 0.5874095526740558 24.64716344285972 -6.877425875680048 1.0940961900011985 1.033225321755012 0.5558508566177148 0.9715472304253369 0.03521224139216308 0.12993269607195507 0.28629598844145143 0.02484734382823332 0.05971142690716005 1.3260934328302478e-07 6.877425875680048 -0.4773744651372972 LCEK(ub)MAQFDAK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LCEKMAQFDAK 11 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 319788100.0 46719400.0 84757100.0 188311600.0 True False 70876745.44564752 69631533.29475506 151091729.72009355 1.0 0.982431301789282 2.1317532114388578 26.078809023222636 -6.903432100449782 0.9393402945092193 0.9566102872239739 2.2611565600989754 0.9881971390837057 0.05841651144140736 0.10892213611411498 0.16352484186424626 0.04632467826410893 0.12273931210392747 1.249015706052224e-07 6.903432100449782 1.3045462728750015 up LCEK(ub)MAQFDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LCEKMAQFDAK 11 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 67964230.0 22976700.0 17822600.0 27164930.0 True False 31471806.911970302 17035138.600543234 20749133.013294872 1.0 0.5412825087606876 0.6592927146297068 24.907556675644308 -10.122926857846368 7.642928269610775 1.0000000791298782 0.6002876116952093 0.9386374941249663 0.04817746480331563 6.495833739420925e-08 7.457683223477157e-09 0.04664763874769345 0.015549209903811291 7.534824515735893e-11 10.122926857846368 -0.3997124674346689 LCEK(ub)MAQFDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LCEKMAQFDAK 11 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 72452380.0 27135980.0 11966000.0 33350400.0 True False 22564769.697743397 11901536.782934956 40323814.445172936 1.0 0.5274388767249495 1.7870253047256024 24.427568718293998 -6.80507136640696 1.4349853351966737 0.7409136356738807 1.80669629141651 0.8466038694229793 0.20348144247062075 0.21360162605157296 0.8677342125572726 0.11152389350877792 0.25862035112783566 1.5664936314055094e-07 6.80507136640696 1.065782655742629 LCEK(ub)MAQFDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LCEKMAQFDAK 11 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 222313900.0 46719400.0 69281700.0 106312800.0 True False 60479184.27705434 65426112.491491064 86964961.2614461 1.0 1.0817955512060962 1.4379321133542537 25.849935345315085 -6.9429320099568645 0.6317026502386754 0.9961146397441287 1.5428627772758687 0.9985232177686069 0.007306079782809682 0.086454224254115 0.0487079232052019 0.007281154142433987 0.030278353550505642 1.1404283109000979e-07 6.9429320099568645 0.54674813753174 LCEK(ub)VFDPQNDKPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LCEKVFDPQNDKPSK 15 2 O15145 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 1 3036500.0 1224100.0 872460.0 939940.0 True False 1185241.615538462 1220837.8278187937 693741.5164044283 1.0 1.0300328741529718 0.5853165357252981 20.176749756723968 -6.890737196293579 1.018029134508322 1.0234746000734702 0.5465122814581752 0.9813653319901238 0.02770217923129619 0.11854635458970098 0.21837881122323474 0.020713820123253825 0.05177796998973666 1.2860646581273785e-07 6.890737196293579 -0.47696231861529503 LCEK(ub)VFDPQNDKPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCEKVFDPQNDKPSK 15 2 O15145 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 1 62176400.0 2700300.0 6620100.0 52856000.0 True False 4096552.5183731364 5438691.431922619 42408988.43239224 1.0 1.3276264389459083 10.352360489017755 21.9659788798182 -6.91458764740252 0.8639150686596364 0.7594658665637056 11.640750928571416 0.9925406104248656 0.374282218526696 0.10146172643743234 0.12289182592130718 0.31355834593990517 0.8957063061248723 1.2173412895869297e-07 6.91458764740252 10.881285062007711 up LCEK(ub)VFDPQNDKPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCEKVFDPQNDKPSK 15 2 O15145 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 1 49305600.0 2700300.0 7798000.0 38807300.0 True False 3495591.5808706824 7364034.445007093 31744769.596523777 1.0 2.106663285638438 9.08137259805872 21.737105201910648 -6.934803254225134 0.706253834073881 0.9104428139593582 10.705708006932097 0.9974008787239093 0.1823812904021431 0.09021949361184785 0.06601712127671756 0.17119147108149993 0.6152798991039464 1.1619748970078869e-07 6.934803254225134 9.795265192972739 LCELQPEEK(ub)CCVVGTLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCELQPEEKCCVVGTLFK 18 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7;C9IZD2 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 16305200.0 2214100.0 6287700.0 7803400.0 True False 2902706.541374902 5349599.669262639 6995979.023498355 1.0 1.8429695158673316 2.4101571839172644 21.468967294680596 -8.183943393369074 0.1450034844263732 1.8008432793618325e-21 3.5649741130954196 0.9999393172521469 0.004513101154074776 0.08770370027479425 0.02915548843817008 0.31208116237583633 0.33439303837127704 6.547215059445227e-09 8.183943393369074 3.5649741130954196 LCELQPEEK(ub)CCVVGTLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCELQPEEKCCVVGTLFK 18 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7;C9IZD2 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 173390300.0 7575300.0 37185000.0 128630000.0 True False 11492283.928612402 30549046.222268928 103206224.11946812 1.0 2.658222370073089 8.980479838521482 23.45416220588944 -6.945977525291751 0.6013868843842971 0.9290004805826755 11.034111899610394 0.9988466077664775 0.11677659922705787 0.08514232239714013 0.04296518366147305 0.11968941363660127 0.5315477031892373 1.1324589663893719e-07 6.945977525291751 10.105111419027718 LCELQPEEK(ub)CCVVGTLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCELQPEEKCCVVGTLFK 18 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7;C9IZD2 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 18428600.0 2214100.0 4925500.0 11289000.0 True False 3032712.603802703 4707875.123549637 8622770.704253085 1.0 1.55236441384075 2.843253493074496 21.532177356203487 -6.956890052364344 0.4772550170642497 0.9682002684821079 3.4809885686529602 0.9996368761595398 0.014718251268451235 0.08083144651962697 0.025383186269719044 0.018101035546527592 0.10649903587953373 1.1043581680107261e-07 6.956890052364344 2.512788300170852 LCELQPEEK(ub)CCVVGTLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCELQPEEKCCVVGTLFK 18 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7;C9IZD2 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 174301300.0 7575300.0 13626000.0 153100000.0 True False 9806375.18148714 12867701.121783355 125237370.9386582 1.0 1.3121771178075572 12.771015652662998 23.22528852798189 -6.912738800803521 0.8768840400515637 0.6752019609106752 14.341984382672946 0.9919145761654676 0.49246939109316334 0.10263445384063853 0.1291520953122903 0.4087329047339295 1.150879901848229 1.2225347122797e-07 6.912738800803521 13.66678242176227 up LCENSDPTNVLSCHFSK(ub)ADTIATIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCENSDPTNVLSCHFSKADTIATIEK 26 1 Q13107-2;Q13107;C9JNU9;Q13107-3 Q13107-2 USP4 Ubiquitin carboxyl-terminal hydrolase 4 1 37273600.0 4780600.0 8467000.0 24026000.0 True False 7252519.708674829 6955997.697027061 19277250.569030117 1.0 0.9591146217371743 2.6580073330889893 22.790050880267103 -6.901385652782946 0.9524566835547514 0.932026616949764 2.8414453744828085 0.9872434385593417 0.08938519306378828 0.11039282332719924 0.17171913431356695 0.07019742697208557 0.18394675251723344 1.2549151062297676e-07 6.901385652782946 1.9094187575330446 up LCFK(ub)ENAEQGEVDMESHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCFKENAEQGEVDMESHR 18 1 P14209;P14209-3 P14209 CD99 CD99 antigen 1 10313900.0 4359000.0 3036500.0 2918400.0 True False 5714691.212616048 2583466.036184293 2616431.963269551 1.0 0.4520744761293314 0.4578431040146807 22.446244115346957 -9.913455832751774 6.021405702079315 1.0000001562809662 0.4549587900723535 0.9999159933321558 0.0023550324731853836 4.940745234880791e-09 8.88762167010836e-10 0.0022802510154010416 0.0007600834622706667 1.220517939700488e-10 9.913455832751774 -0.5450413662086127 LCFK(ub)ENAEQGEVDMESHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCFKENAEQGEVDMESHR 18 1 P14209;P14209-3 P14209 CD99 CD99 antigen 1 10536100.0 4359000.0 3748000.0 2429100.0 True False 5970640.097545719 3582400.9670214267 1855396.608884858 1.0 0.6000028319399126 0.3107533829827616 22.50945417686985 -8.010182515089902 0.22443852313411422 1.2126881493003574 4.078555015535822e-16 0.9997439036723379 0.004522318059027214 0.1010410631102592 0.04039997038845912 0.0741084586737572 0.0998979407839612 9.768266169225381e-09 8.010182515089902 -1.212688149300357 down LCFQVTVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LCFQVTVR 8 0 Q2TAM5;E9PKH5;A0A087X0W8;Q04206-2;Q04206-3;Q04206-4;Q04206;E9PI38;E9PQS6;E9PKV4;A0A087WVP0 Q2TAM5 RELA Transcription factor p65 0 10466800.0 6722800.0 1714200.0 2029800.0 False True 6509388.393874663 2398688.999434906 1498134.4873052635 1.0 0.3684968316980553 0.23014980773232224 22.634090567004648 -13.999999999999938 0.2133704601453561 4.703755823160396 0.15127706193514934 0.9994921704867652 0.007551416229374367 12.827731312081433 0.14638501528671036 19.950633223912153 0.08005701130836576 1.0000000000001431e-14 13.999999999999938 -4.552478761225247 LCFQVTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCFQVTVR 8 0 Q2TAM5;E9PKH5;A0A087X0W8;Q04206-2;Q04206-3;Q04206-4;Q04206;E9PI38;E9PQS6;E9PKV4;A0A087WVP0 Q2TAM5 RELA Transcription factor p65 0 213910000.0 72820000.0 76250000.0 64840000.0 False True 110473263.855102 62642591.75603087 52024345.57961843 1.0 0.5670384812581768 0.4709224998353824 26.71912201766776 -13.999999999999993 0.2114971047841905 3.5195069003071326 0.41512508600311354 0.999490904713617 0.005192335674232114 12.782132290193738 0.14575432332995364 13.392192112547988 0.056342937418669546 1.0000000000000164e-14 13.999999999999993 -3.104381814304019 LCFQVTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCFQVTVR 8 0 Q2TAM5;E9PKH5;A0A087X0W8;Q04206-2;Q04206-3;Q04206-4;Q04206;E9PI38;E9PQS6;E9PKV4;A0A087WVP0 Q2TAM5 RELA Transcription factor p65 0 8122400.0 1049900.0 2519500.0 4553000.0 False True 1438076.4024806707 2408180.1591276624 3477675.17197841 1.0 1.674584295363981 2.4182826211315662 20.45570889499838 -6.969870089377991 0.26127140895392365 0.794420624866154 3.320547364207585 0.9999813513267012 0.0025013921781157347 0.07634487788256879 0.009180914396119516 0.015398324134223379 0.07003615610015732 1.0718398770317284e-07 6.969870089377991 2.526126739341431 LCFQVTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCFQVTVR 8 0 Q2TAM5;E9PKH5;A0A087X0W8;Q04206-2;Q04206-3;Q04206-4;Q04206;E9PI38;E9PQS6;E9PKV4;A0A087WVP0 Q2TAM5 RELA Transcription factor p65 0 194142000.0 72820000.0 71944000.0 49378000.0 False True 94266925.49679784 67940253.15614131 40391710.66106506 1.0 0.7207220644790115 0.42848231708200907 26.49024833976021 -6.970553685854387 0.2446095223752798 1.0991156174769907 0.04158761707026292 0.9999863818659755 0.0008610736805336353 0.07612352845343948 0.00838518142881616 0.006763527115558449 0.028262020984553597 1.0701540863015996e-07 6.970553685854387 -1.0575280004067278 down LCFSTAQHAS ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCFSTAQHAS 10 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 60845000.0 19472000.0 18358000.0 23015000.0 False True 25527980.567116216 15619057.958923511 20633628.575469002 1.0 0.6118407179862535 0.8082750032350049 24.605576079706687 -10.264461526990813 4.718312637133695 1.0000981312545385 0.7100578606099446 0.7439095850239179 0.08019396114374233 8.281087992616191e-05 1.2909273109237473e-05 0.07767365879507243 0.025882489664329593 5.4392431441472574e-11 10.264461526990813 -0.2900402706445939 LCFSTAQHAS ddPTM_RPMI8226_Bortezomib_2h_R1 1 LCFSTAQHAS 10 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 17000500.0 8365300.0 2808500.0 5826700.0 False True 8099748.1304337215 3929948.6961340155 4300512.472746859 1.0 0.48519393848405706 0.5309439754784792 22.94944561600985 -10.06591356967877 7.718692941529454 1.0000000303373209 0.508068957985044 0.9935549301552256 0.018677374391631373 9.74473008337569e-09 1.1870165633910076e-09 0.0180842910703197 0.006028096664139104 8.591844935210133e-11 10.06591356967877 -0.49193107235227684 LCFSTAQHAS ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCFSTAQHAS 10 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 79903300.0 12262000.0 59750000.0 7891300.0 False True 18602350.472277693 49087145.6711192 6331581.096120334 1.0 2.638760394514216 0.34036457411959986 24.148981586644652 -6.715242275694982 1.7762540049034636 2.002024765517639 0.3448251432250037 0.49004966440222375 0.6900285317181499 0.3646492963546846 2.245709106150868 0.3087602609806175 0.7795278554791225 1.9264499232398392e-07 6.715242275694982 -1.6571996222926355 LCFSTAQHAS ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCFSTAQHAS 10 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 56049000.0 19472000.0 14519000.0 22058000.0 False True 26671324.611014023 13877502.572087549 16848354.698769987 1.0 0.5203154614359417 0.6317029598077178 24.668786141229578 -9.859299672026305 6.5417589964688965 1.0000000146274886 0.5760092106218259 0.9507843364378004 0.04547375578944284 9.682411479011742e-09 1.7551333412181547e-09 0.04402977635568596 0.014676591571817062 1.382612019329429e-10 9.859299672026305 -0.4239908040056627 LCFSTAQHAS ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LCFSTAQHAS 10 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 17449000.0 8365300.0 3120000.0 5963700.0 False True 6956117.595625188 3103191.9407284916 7210682.096966699 1.0 0.44610975850669027 1.036595773122296 22.729850891444126 -11.81383097432881 17.714968823243122 0.9129724703934958 0.767217489233041 0.0 0.27680470364640103 0.0 0.0 0.0 0.08032124850583991 1.5352143658184315e-12 11.81383097432881 -0.14575498116045482 LCFSTAQHAS ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCFSTAQHAS 10 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 34136500.0 12262000.0 14243000.0 7631500.0 False True 15873400.72015567 13450364.529396769 6242645.305802546 1.0 0.8473524209791928 0.39327711911637075 23.9201079087371 -6.951641151535649 0.5405260398590214 1.0066621241805933 0.2129792821491124 0.9993238623231989 0.0067004016309378835 0.08283335814201163 0.03328622317693459 0.0073643680431246155 0.03760703540416275 1.1177864699343696e-07 6.951641151535649 -0.7936828420314809 down LCGEEK(ub)VVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCGEEKVVER 10 1 J3KNI1;Q9H9E3;A0A6I8PIQ6;A0A0A0MS45;Q9H9E3-2;E9PRT5;H3BSD2;H3BMV9;J3QLW1 J3KNI1 COG4 Conserved oligomeric Golgi complex subunit 4 1 17744300.0 2496400.0 6171000.0 9076900.0 True False 3787221.311286416 5069736.835756938 7282846.736453409 1.0 1.3386428779982986 1.9230053218040286 21.852708298802728 -6.962824752029472 0.39360419078716313 0.9655208175184601 2.3172459033048423 0.9998610470123167 0.004493992613317109 0.0787070662247429 0.017512676565100617 0.007531676795938373 0.04908201934463042 1.089369590736189e-07 6.962824752029472 1.351725085786382 LCGEEK(ub)VVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCGEEKVVER 10 1 J3KNI1;Q9H9E3;A0A6I8PIQ6;A0A0A0MS45;Q9H9E3-2;E9PRT5;H3BSD2;H3BMV9;J3QLW1 J3KNI1 COG4 Conserved oligomeric Golgi complex subunit 4 1 18359900.0 2496400.0 4888500.0 10975000.0 True False 3231639.0114008 4616450.677663133 8977662.613009633 1.0 1.4285168180532843 2.7780524313939807 21.623834620895177 -6.950354109921749 0.5549460809318193 0.9818604560709212 3.2886478384506126 0.9992287553714096 0.021041003254430226 0.08334393542623453 0.03537683069936684 0.02269497146421992 0.11206380875585735 1.1211039689759092e-07 6.950354109921749 2.3067873823796914 up LCGPYEK(ub)FICEQDHQNFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCGPYEKFICEQDHQNFLR 19 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 9550700.0 2542000.0 4402600.0 2606100.0 True False 3332586.616763021 3745749.2412003838 2336445.7714764173 1.0 1.1239765599366993 0.7010907862751468 21.66821094199792 -6.828214317130242 1.3357785356666896 1.0663342010879162 0.6901142922365637 0.9022607354050164 0.05549163913898262 0.18303513503944063 0.6393377766013049 0.03262234725742643 0.07508421306085922 1.4852025385727236e-07 6.828214317130242 -0.3762199088513525 LCGPYEK(ub)FICEQDHQNFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCGPYEKFICEQDHQNFLR 19 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 31223500.0 8228500.0 12816000.0 10179000.0 True False 12483236.083928963 10528884.668134967 8167116.188385804 1.0 0.8434419246216094 0.654246714031166 23.57348864304651 -6.968599531193742 0.28969021478860996 1.0371047053698128 0.4547411085357799 0.9999693031015712 0.0007831954068810539 0.07675979454535128 0.010648460387325259 0.0033108491571815415 0.017163225204984024 1.0749802092243671e-07 6.968599531193742 -0.5823635968340328 LCGPYEK(ub)FICEQDHQNFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCGPYEKFICEQDHQNFLR 19 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 11379000.0 2542000.0 4755900.0 4081100.0 True False 3481846.094967018 4545768.612341839 3117228.2328928416 1.0 1.3055627642223224 0.8952803047207547 21.73142100352081 -6.707309706290836 1.8049580172027608 1.1883673544461673 0.8963246699914058 0.45227518785142284 0.12881779338894414 0.3804911780276897 2.4146970416033766 0.056833317584020895 0.14484749465477087 1.961960654477123e-07 6.707309706290836 -0.29204268445476145 LCGPYEK(ub)FICEQDHQNFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCGPYEKFICEQDHQNFLR 19 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 29272000.0 8228500.0 12876000.0 8167500.0 True False 10651955.457984088 12159439.281086337 6681098.805626989 1.0 1.1415217918483058 0.6272180570018461 23.34461496513896 -6.833326596137759 1.3127883642350688 1.075469370645416 0.6123961894619967 0.9123841466129621 0.06420936894821233 0.1767541174396907 0.5945413743270117 0.03838621263957313 0.08834884738080646 1.4678220377189617e-07 6.833326596137759 -0.4630731811834192 LCGQDLNK(ub)TSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCGQDLNKTSR 11 1 A0A1W2PPC6;Q9H3H5-2;Q9H3H5;F8W681;A0A1W2PQD1;F8WE55;A0A1W2PRR6 A0A1W2PPC6 DPAGT1 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 18610900.0 2014300.0 2488600.0 14108000.0 True False 2640766.8065089476 2117310.5804868233 12648239.493491923 1.0 0.801778701272709 4.789608632733724 21.332525478952313 -6.895206968395422 0.9910877174777047 0.8117009579510204 5.1697148168043325 0.9840265728420933 0.2319114204873784 0.11501933259972492 0.19799046189158107 0.176962467640622 0.4502879357186124 1.2728963219965378e-07 6.895206968395422 4.358013858853312 up LCGQDLNK(ub)TSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LCGQDLNKTSR 11 1 A0A1W2PPC6;Q9H3H5-2;Q9H3H5;F8W681;A0A1W2PQD1;F8WE55;A0A1W2PRR6 A0A1W2PPC6 DPAGT1 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 11215400.0 1422700.0 2549600.0 7243100.0 True False 1377537.167246606 3567668.575988355 5345914.821657678 1.0 2.5898891593025692 3.880777193360951 20.393659813912972 -7.405067398865817 0.1927483144984299 2.017820797832805e-16 5.947608480499836 0.9999701064850846 0.006441703370861769 0.12510045247700546 0.015387125623455547 0.1349864285801273 0.2921403256291277 3.934890045195261e-08 7.405067398865817 5.947608480499836 LCGQDLNK(ub)TSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCGQDLNKTSR 11 1 A0A1W2PPC6;Q9H3H5-2;Q9H3H5;F8W681;A0A1W2PQD1;F8WE55;A0A1W2PRR6 A0A1W2PPC6 DPAGT1 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 75164400.0 3259400.0 38254000.0 33651000.0 True False 4944748.094058222 31427274.82013383 26999865.100242727 1.0 6.355687736226223 5.460311544017113 22.237465595321712 -10.328533952198708 5.396341073758451 0.9988319961083112 5.90799964012182 0.9756468058536877 0.3655357997919572 0.005136723173532689 0.0006391620071669573 0.3539370477750511 0.11797617208632596 4.693167427200376e-11 10.328533952198708 4.909167644013508 LCGQDLNK(ub)TSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCGQDLNKTSR 11 1 A0A1W2PPC6;Q9H3H5-2;Q9H3H5;F8W681;A0A1W2PQD1;F8WE55;A0A1W2PRR6 A0A1W2PPC6 DPAGT1 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 20714600.0 2014300.0 2738300.0 15962000.0 True False 2759041.1444107224 2617312.8516528234 12192104.34770906 1.0 0.9486313232243698 4.418964310266948 21.395735540475204 -6.903542931878146 0.9386151593960624 0.8694044408352299 4.810596747944408 0.988247559393318 0.17605117219065416 0.10884363531502429 0.16308397708497224 0.13968372647418412 0.37033170222018696 1.2486969994178753e-07 6.903542931878146 3.941192307109178 up LCGQDLNK(ub)TSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LCGQDLNKTSR 11 1 A0A1W2PPC6;Q9H3H5-2;Q9H3H5;F8W681;A0A1W2PQD1;F8WE55;A0A1W2PRR6 A0A1W2PPC6 DPAGT1 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 16192100.0 1422700.0 2422400.0 12347000.0 True False 1183038.086296479 2409350.0503912494 14928700.61392217 1.0 2.03657860072262 12.61895182145549 20.17406508934725 -6.9258616331723655 0.7800221117666348 0.8120116187121571 14.578891490705042 0.9956602894854225 0.34585058146690684 0.0948444869143517 0.0886325354941277 0.3076472329333829 0.9802132604802983 1.1861465959323058e-07 6.9258616331723655 13.766879871992884 up LCGQDLNK(ub)TSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCGQDLNKTSR 11 1 A0A1W2PPC6;Q9H3H5-2;Q9H3H5;F8W681;A0A1W2PQD1;F8WE55;A0A1W2PRR6 A0A1W2PPC6 DPAGT1 UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 1 57696400.0 3259400.0 40997000.0 13440000.0 True False 4219357.552379334 38715480.91074062 10994057.906045511 1.0 9.17568147049036 2.605623668903305 22.00859191741416 -6.591690091055534 2.2218727880556166 6.527477232104413 2.6248678306475512 0.0 3.541242009262148 0.6646578616802812 6.188152708562848 1.3290525496694268 3.946740623577436 2.560412324186236e-07 6.591690091055534 -3.902609401456862 LCHIAFHVPAGQPLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCHIAFHVPAGQPLAR 16 0 Q96IR7 Q96IR7 HPDL 4-hydroxyphenylpyruvate dioxygenase-like protein 0 11857000.0 2632000.0 5240500.0 3984500.0 False True 3407175.88447641 4948861.568230264 3259361.8844224913 1.0 1.4524819780446316 0.9566168565798493 21.700144993163576 -6.666599347239932 1.9493171923588744 1.2896587982498835 0.9586449615453766 0.26407297956763487 0.19235676026392068 0.46900318179034756 3.4324011488494253 0.07953318167451667 0.2134480767672266 2.1547686720550587e-07 6.666599347239932 -0.3310138367045069 LCIEVTPQSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCIEVTPQSK 10 0 P61221;D6R9I9;D6RGF4 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 28661200.0 10018000.0 5922200.0 12721000.0 False True 13133695.014449995 5038630.844554799 11404752.948448451 1.0 0.38364152959324704 0.8683582903288586 23.64676952325086 -10.00648316612374 6.97329679312085 1.000000044135084 0.6259999099610883 0.44252139908392785 0.19788478892949626 1.3567109097339584e-07 1.9243230086450187e-08 0.1916011458384642 0.06386704099930886 9.851828291617173e-11 10.00648316612374 -0.3740001341739957 LCIEVTPQSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCIEVTPQSK 10 0 P61221;D6R9I9;D6RGF4 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 27850000.0 10018000.0 5724000.0 12108000.0 False True 13721925.326270469 5471094.753263252 9248339.772087537 1.0 0.39871188795852897 0.6739826629417445 23.709979584773752 -10.436577835587219 6.113874388202562 1.000166533065078 0.5363472754501595 0.7909139420679051 0.11237882330156067 0.0002551860121777278 2.3516402454313744e-05 0.10884880848952944 0.03627010925944415 3.65950347938167e-11 10.436577835587219 -0.4638192576149185 LCIYIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCIYIR 6 0 B9ZVT1;Q8IXT5 B9ZVT1 RBM12B RNA-binding protein 12B 0 19941100.0 5709900.0 6945200.0 7286000.0 False True 8662335.749605138 5705774.796904723 5845918.906432749 1.0 0.6586877906648694 0.6748663496100608 23.04632466125204 -10.2694728748522 8.3956168947703 1.0000002451935324 0.6667770701422242 0.9982351639214475 0.00660486903154322 3.030669828106484e-08 2.6446847069059616e-09 0.006395141610073117 0.00213171231358733 5.3768401472072964e-11 10.2694728748522 -0.33322317505130816 LCIYIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCIYIR 6 0 B9ZVT1;Q8IXT5 B9ZVT1 RBM12B RNA-binding protein 12B 0 11061400.0 2668300.0 4294200.0 4098900.0 False True 3654842.61809618 4104468.0449795695 3130824.2394953417 1.0 1.123021829902378 0.8566235448809008 21.801377852661748 -6.781154670552308 1.5315385763486042 1.069553997935927 0.8544426665204072 0.7713964075984832 0.052049849733439964 0.24878661473221422 1.1527328934406698 0.026766465935069164 0.06309251904725957 1.6551803790584098e-07 6.781154670552308 -0.21511133141551975 LCIYIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCIYIR 6 0 B9ZVT1;Q8IXT5 B9ZVT1 RBM12B RNA-binding protein 12B 0 19197200.0 5709900.0 6313000.0 7174300.0 False True 7391578.1089558555 5961676.000426995 5868651.014534396 1.0 0.8065498209649778 0.7939645537160412 22.81745098334449 -13.999999999999998 0.38839019936692376 4.027390371320208 0.7930175832187728 0.999820688719892 0.0012627278363906943 25.129013471579867 0.20408988660213312 63.82486875498652 0.003327558613000647 1.0000000000000041e-14 13.999999999999998 -3.2343727881014352 LCK(ub)DWAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCKDWAEK 8 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 26486400.0 6014300.0 10023400.0 10448700.0 True False 7884805.542564055 8527947.790907176 9367568.755007729 1.0 1.081567293558641 1.1880532378939932 22.910643744601483 -6.967462175591322 0.3129246312371609 0.9841513556815561 1.288868455984337 0.9999552712202167 0.0005149186723287543 0.07713505393592919 0.011963373067315083 0.0016630270542942012 0.009427513784013648 1.0777991193565153e-07 6.967462175591322 0.304717100302781 LCK(ub)DWAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LCKDWAEK 8 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 16376700.0 4652800.0 6468200.0 5255700.0 True False 4505099.4108139565 9050985.991217403 3879074.5023796796 1.0 2.0090535559529683 0.8610408225550854 22.103127510636224 -6.674544917274771 1.9209957357717669 1.6415230932683262 0.8655465540749743 0.29948302045702135 0.428177025634027 0.45074395525175154 3.2108757391376006 0.17915730486115874 0.47589092614523276 2.1157048553574947e-07 6.674544917274771 -0.775976539193352 LCK(ub)DWAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCKDWAEK 8 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 78442500.0 17537900.0 14651600.0 46253000.0 True False 26606276.492232807 12036907.506526692 37111074.27658995 1.0 0.45240857021239467 1.3948240479055316 24.665263285730386 -6.749187106489643 1.6529388035283084 0.6776972103851333 1.3965730419376843 0.6454457991329188 0.23009215766362578 0.30145733379536716 1.6202829381760238 0.10997759686429863 0.2672151759667797 1.7816110330671913e-07 6.749187106489643 0.718875831552551 LCK(ub)DWAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCKDWAEK 8 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 21431300.0 6014300.0 5073500.0 10343500.0 True False 8237949.240346235 4849335.9941790905 7900578.331069328 1.0 0.5886581541955794 0.9590467360948769 22.973853806124374 -10.33186324040952 8.2711761508321 1.000000673154983 0.7738524451452282 0.33202335153223617 0.1512105053677227 1.8770011851427248e-06 1.5166692045113513e-07 0.1464093763930337 0.04880298075506644 4.6573272994727334e-11 10.33186324040952 -0.22614822800975487 LCK(ub)DWAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LCKDWAEK 8 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 20232900.0 4652800.0 5050300.0 10529800.0 True False 3869009.35398908 5023093.031493939 12731532.495705659 1.0 1.298289192895065 3.290644020433555 21.8835327860705 -6.933610831693794 0.7165411250878801 0.9733827908895577 3.739991238628498 0.9972014128572338 0.05379205248527496 0.09080593935912301 0.06881177247498127 0.05010558864455772 0.1768313426651458 1.1651696622864617e-07 6.933610831693794 2.7666084477389403 up LCK(ub)DWAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCKDWAEK 8 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 64230500.0 17537900.0 11744600.0 34948000.0 True False 22703157.273692537 11091002.685666868 28587822.596761774 1.0 0.4885224795812279 1.259200306465222 24.436389607822836 -6.727767078917482 1.7312494304194082 0.6914319354913634 1.2585674283777952 0.5489151412383257 0.21505381888758637 0.3404515141868319 1.998006030218016 0.09847785703880484 0.24499770547226654 1.871685694846441e-07 6.727767078917482 0.5671354928864318 LCK(ub)EVPNYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCKEVPNYK 9 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 25435500.0 5837500.0 5808000.0 13790000.0 True False 8855914.278414693 4771517.021888884 11064400.455628287 1.0 0.5387944002031418 1.249379805154227 23.07820982682027 -6.731537043452953 1.717888310877749 0.7229227042004375 1.249057070046099 0.5662861450091833 0.1938568097248022 0.33335204476908925 1.9280343149142716 0.08940581712451712 0.22144721342858872 1.855508535779471e-07 6.731537043452953 0.5261343658456615 LCK(ub)EVPNYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCKEVPNYK 9 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 9501200.0 2397900.0 2514900.0 4588400.0 True False 3284468.430810939 2403783.4023378305 3504714.4210642916 1.0 0.7318637560307845 1.067056814487017 21.647228468246883 -6.6936964714242455 1.853416029048302 0.8324783687986209 1.0659477956155567 0.38769213095107946 0.1133195653525307 0.4087865201396739 2.725395444173734 0.048861866779417 0.12664372006769747 2.0244335617373668e-07 6.6936964714242455 0.23346942681693583 LCK(ub)EVPNYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCKEVPNYK 9 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 25364400.0 5837500.0 8376900.0 11150000.0 True False 7556758.824327895 7910718.151113089 9120814.408661257 1.0 1.0468400983826125 1.206974394802453 22.84933614891272 -6.948483001806598 0.5752623371705305 0.9980499088342474 1.2636208096232462 0.9990767506196889 0.002692597017255439 0.0841007976921409 0.038528761389723054 0.002835812772347527 0.013360061333460401 1.1259445372615854e-07 6.948483001806598 0.2655709007889988 LCK(ub)EVPNYK(ub)LITPAVVSER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCKEVPNYKLITPAVVSER 19 2 P62851 P62851 RPS25 40S ribosomal protein S25 2 8834900.0 2134000.0 1907300.0 4793600.0 True False 2797694.665685397 1622738.2745971708 4297604.255458099 1.0 0.5800269395014992 1.5361234048052361 21.415807087817385 -6.787306365054564 1.5070883855847648 0.7644538241165657 1.5455500819707662 0.7924813683136044 0.17824619190121752 0.2393875844442903 1.0741799841986623 0.09310919346567666 0.2184258792247908 1.6319003476687037e-07 6.787306365054564 0.7810962578542004 LCK(ub)EVPNYK(ub)LITPAVVSER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCKEVPNYKLITPAVVSER 19 2 P62851 P62851 RPS25 40S ribosomal protein S25 2 9878900.0 2134000.0 2931600.0 4813300.0 True False 2922997.469181593 2802072.2184952 3676497.673025191 1.0 0.9586297107810187 1.2577833924894124 21.479017149340276 -6.871941461359961 1.123848994556247 0.9763067398043164 1.2759563383803347 0.9665790178778282 0.02419605473101161 0.13500313594948746 0.31751715640330586 0.016688986406710758 0.039648362007003043 1.3429459648939093e-07 6.871941461359961 0.29964959857601836 LCK(ub)TVGATALPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LCKTVGATALPR 12 1 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 4348450.0 2127800.0 1416500.0 804150.0 True False 2060254.1536988323 1982115.8369499145 593518.9910171088 1.0 0.9620734574864787 0.2880804729608468 20.97439088909381 -6.9184904961181095 0.835860642848053 1.0156960457066648 0.18308438933294222 0.9937508474427729 0.025852194999328264 0.09906825411324968 0.11028186037499603 0.022097995306229683 0.06526683589501905 1.2064504892635072e-07 6.9184904961181095 -0.8326116563737226 down LCK(ub)TVGATALPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCKTVGATALPR 12 1 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 12106600.0 7702800.0 1065300.0 3338500.0 True False 9971426.444887863 1006015.1185260385 2730927.2559027444 1.0 0.10088978984965595 0.2738752846442379 23.249368470914785 -10.022376153443625 6.890833623786174 1.000000149019423 0.187382537246948 0.9671304763788513 0.07062103252493739 1.6164653289163544e-07 2.3067089673776665e-08 0.06837853294190493 0.022792840238420663 9.49781807238948e-11 10.022376153443625 -0.812617611772475 LCLGQGADIWAYILQHVHSQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCLGQGADIWAYILQHVHSQR 21 0 O94927;O94927-2;U3KQG4 O94927 HAUS5 HAUS augmin-like complex subunit 5 0 66035000.0 16888000.0 17312000.0 31835000.0 False True 25620330.678178564 14222538.340726633 25542798.296223853 1.0 0.555127040293836 0.9969737946426762 24.61078576068304 -10.939101973512827 10.223832001212328 1.0533997304969278 0.7760504174682562 0.2551365052979452 0.18038318210992046 0.10559452564372093 0.0006289706618454945 0.08399867385188242 0.058218421687301784 1.1505302096375212e-11 10.939101973512827 -0.2773493130286716 LCLGQGADIWAYILQHVHSQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCLGQGADIWAYILQHVHSQR 21 0 O94927;O94927-2;U3KQG4 O94927 HAUS5 HAUS augmin-like complex subunit 5 0 40836100.0 16888000.0 14716000.0 9232100.0 False True 21861848.912248317 13897041.663596332 7551952.529345443 1.0 0.635675496586676 0.34543979146770093 24.38191208277549 -7.682126527784171 0.22338382013372904 1.1810295721640123 6.595034340106603e-15 0.9998656331102019 0.00310416445765863 0.13041478462937303 0.02801365792142356 0.04292831522060046 0.07983161057130703 2.0790908744659478e-08 7.682126527784171 -1.1810295721640056 down LCLNICVGESGDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCLNICVGESGDR 13 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 5308900.0 5308900.0 0.0 0.0 False True 8053989.432578299 0.0 0.0 1.0 0.0 0.0 22.94127214868794 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 LCLNICVGESGDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCLNICVGESGDR 13 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 322288900.0 5308900.0 316980000.0 0.0 False True 6872475.70406414 299339784.35218614 0.0 1.0 43.556324859055835 0.0 22.71239847078039 -3.847643523546459 10.589906446717649 9.999999999958522 19.072259272827658 0.0 20.872844703487324 0.0 0.0 7.197345966258457 0.0 0.00014202227869185264 3.847643523546459 9.072259272869136 LCLQHLQIFTYER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCLQHLQIFTYER 13 0 H3BQQ2;H3BPG6;Q86UK7-2;Q86UK7-3;Q86UK7 H3BQQ2 ZNF598 Zinc finger protein 598 0 14140100.0 2182700.0 4720300.0 7237100.0 False True 2989703.175249605 4511741.538055292 5527846.032753125 1.0 1.5090934696815228 1.848961488389768 21.51157082670661 -8.238886493569662 0.1034344003140733 4.835040452203497e-14 2.93112974384585 0.9999828069878157 0.0014465785104476484 0.08607328920539838 0.021199346734648076 0.2818701912226254 0.2875045492177662 5.769172257459117e-09 8.238886493569662 2.9311297438458017 LCLQHLQIFTYER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCLQHLQIFTYER 13 0 H3BQQ2;H3BPG6;Q86UK7-2;Q86UK7-3;Q86UK7 H3BQQ2 ZNF598 Zinc finger protein 598 0 14819500.0 3453300.0 5391200.0 5975000.0 False True 4470364.924719743 5091174.980754318 4887611.308677224 1.0 1.1388723440902297 1.093336090226155 22.091961175586075 -10.20344567492651 4.643645402186041 0.9999767763980769 1.116104217159002 0.8965662432542196 0.018590097796915634 4.470546681644347e-06 7.668417048031626e-07 0.018003384158735574 0.005999928263925871 6.259711605702304e-11 10.20344567492651 0.11612744076092518 LCLTLHNNEGSYLAHTQGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCLTLHNNEGSYLAHTQGK 19 0 Q15428;K7EMT0 Q15428 SF3A2 Splicing factor 3A subunit 2 0 229442800.0 60911000.0 72328800.0 96203000.0 False True 79854910.86296304 61537624.97545415 86248836.40433826 1.0 0.7706179157980314 1.0800692840587809 26.250877796454034 -6.708191474500724 1.8018716178954919 0.8587202363274439 1.0792976599800341 0.4564332436978754 0.09668808612804154 0.37870898042130047 2.395746280285381 0.04272247556509405 0.10876492005215059 1.957981236017658e-07 6.708191474500724 0.22057742365259025 LCLTLHNNEGSYLAHTQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LCLTLHNNEGSYLAHTQGK 19 0 Q15428;K7EMT0 Q15428 SF3A2 Splicing factor 3A subunit 2 0 78642900.0 44597000.0 13985000.0 20060900.0 False True 43181292.646163575 19569283.430811573 14806348.475900143 1.0 0.45318892121100496 0.3428880324919038 25.363903095767796 -13.999999999999954 0.2250492428553232 4.374638453868174 0.28666853627091937 0.9995034472312985 0.006402438065099453 13.1419196252139 0.15024448503907994 19.76289071138472 0.059072871029640345 1.0000000000001063e-14 13.999999999999954 -4.087969917597254 LCLTLHNNEGSYLAHTQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCLTLHNNEGSYLAHTQGK 19 0 Q15428;K7EMT0 Q15428 SF3A2 Splicing factor 3A subunit 2 0 286962000.0 60911000.0 94891000.0 131160000.0 False True 83431442.75788186 90698401.85742527 100182709.32499196 1.0 1.0871009640889482 1.200778819272277 26.314087857976926 -6.967466524581915 0.3128401248622299 0.9830640983449409 1.3084440959965813 0.9999553310512557 0.000549396288591709 0.07713366775068539 0.011958393733842599 0.0017760043330151223 0.010065042836019599 1.0777883264154193e-07 6.967466524581915 0.3253799976516404 LCLVIGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCLVIGSR 8 0 C9J8T0;P57772;P57772-2 C9J8T0 EEFSEC Selenocysteine-specific elongation factor 0 12865800.0 3723500.0 3604100.0 5538200.0 False True 4881544.55842529 3066382.328671766 4965160.190165647 1.0 0.6281582175418948 1.0171289293254615 22.218906269205252 -10.990325539617432 12.105905101071619 1.1354343508898956 0.8226435734336778 0.21703944717318557 0.15879662812615306 0.06781381650869432 5.419353725179089e-05 0.017962892446746176 0.05125139134720691 1.0225262369962621e-11 10.990325539617432 -0.31279077745621786 LCLVIGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCLVIGSR 8 0 C9J8T0;P57772;P57772-2 C9J8T0 EEFSEC Selenocysteine-specific elongation factor 0 25987000.0 7612900.0 9821200.0 8552900.0 False True 11549325.877540587 8068530.126614159 6862415.566130763 1.0 0.6986148119956194 0.5941832137125657 23.46130530966135 -13.999999999999998 0.14783070524326072 2.4526751445555206 0.47637196608157384 0.9995736406598725 0.0035526675752848556 11.95021785990181 0.12097371771110836 4.990078379510834 0.1059731491782553 1.0000000000000041e-14 13.999999999999998 -1.9763031784739469 LCLVIGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCLVIGSR 8 0 C9J8T0;P57772;P57772-2 C9J8T0 EEFSEC Selenocysteine-specific elongation factor 0 17800800.0 3723500.0 5312900.0 8764400.0 False True 5100178.57380396 5078158.51058915 6694429.228483985 1.0 0.9956824917213856 1.312587222507967 22.282116330728144 -6.90381359334657 0.9368563948795436 0.9881671316482098 1.348551178575401 0.9883696105270263 0.016002272978503332 0.10865200396738897 0.162016514512629 0.012713068803100512 0.03375677304997034 1.2479190275966254e-07 6.90381359334657 0.36038404692719117 LCLVIGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCLVIGSR 8 0 C9J8T0;P57772;P57772-2 C9J8T0 EEFSEC Selenocysteine-specific elongation factor 0 24277200.0 7612900.0 8582900.0 8081400.0 False True 9855049.122693928 8105254.070024527 6610668.122166374 1.0 0.8224468461917634 0.6707899717053175 23.232431631753798 -6.972957125432421 0.1735689340171526 1.1277230934721334 0.36143840644228764 0.999997211436786 0.00022459063608173114 0.07535430849016383 0.005434942038081509 0.006186367555502599 0.01736583563238005 1.0642480780991501e-07 6.972957125432421 -0.7662846870298458 LCLYTACAGIRPDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCLYTACAGIRPDR 14 1 A0A1W2PQT3;A0A1W2PPH1;A0A1W2PQY8;P23368;A0A1W2PQF8;A0A1W2PQH3;P23368-2;A0A1W2PQ37 A0A1W2PQT3 ME2 NAD-dependent malic enzyme, mitochondrial 0 51286000.0 17433000.0 15575000.0 18278000.0 False True 23878451.20911093 14886845.000362532 13961112.847226307 1.0 0.6234426542154622 0.5846741367337669 24.509205928561418 -13.999999999999998 0.3212547492799258 4.88991520679498 0.577084712863816 0.9996964128232448 0.0032637863253743168 18.111259090487206 0.18081323470403243 47.38289875048733 0.012844442649900673 1.0000000000000041e-14 13.999999999999998 -4.3128304939311635 LCNEK(ub)LLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCNEKLLK 8 1 P10155-3;P10155-5;P10155-4;P10155;G5E9R9 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 1 6100980.0 3965000.0 1489300.0 646680.0 True False 5198153.397114614 1267102.2452459305 579767.756992583 1.0 0.24376007178804543 0.11153340671216051 22.3095677775843 -13.999999999999998 0.24530801643793582 6.1374514375219125 0.055942729610275896 0.999534094997416 0.008448332083600574 13.816836792138172 0.1567367825122458 34.88061372652705 0.06265569156724161 1.0000000000000041e-14 13.999999999999998 -6.081508707911636 LCNEK(ub)LLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LCNEKLLK 8 1 P10155-3;P10155-5;P10155-4;P10155;G5E9R9 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 1 9501920.0 5788400.0 3077500.0 636020.0 True False 5604650.410409965 4306361.798950486 469427.28180899227 1.0 0.7683551129169335 0.08375674617226571 22.41819295718146 -7.2224707886589306 0.6857018166128698 0.9968726903898594 4.298875725707754e-21 0.9959193430648964 0.024848843317321196 0.0908372915068571 0.07732756920958626 0.022683650010496194 0.0585333612343373 5.991412364533769e-08 7.2224707886589306 -0.9968726903898594 down LCNEK(ub)LLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCNEKLLK 8 1 P10155-3;P10155-5;P10155-4;P10155;G5E9R9 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 1 12672340.0 3965000.0 5345600.0 3361740.0 True False 5430967.650096064 5109413.71646472 2567766.2492085868 1.0 0.94079251537695 0.4728008735539361 22.37277783910719 -6.930320476998597 0.7441562284922787 1.0070327405084292 0.3759355907271311 0.9966008700125205 0.01374825406585896 0.09247174313427725 0.07686726610382298 0.012549282527381007 0.04227078622972903 1.1740308878110484e-07 6.930320476998597 -0.631097149781298 down LCNEK(ub)LLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LCNEKLLK 8 1 P10155-3;P10155-5;P10155-4;P10155;G5E9R9 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 1 7549220.0 5788400.0 1176600.0 584220.0 True False 4813311.069599031 1170261.4222631867 706377.7008719221 1.0 0.24313022893005634 0.14675504879238283 22.198598232615737 -13.999999999999998 0.29058248197415565 7.543380270791542 0.1206462782095447 0.9996287661097002 0.007351327032453211 16.000421297387717 0.17095778033003323 62.60768024284329 0.03630292356194438 1.0000000000000041e-14 13.999999999999998 -7.422733992581997 LCPGGQLPFLLYGTEVHTDTNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCPGGQLPFLLYGTEVHTDTNK 22 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 54100000.0 12255000.0 27970000.0 13875000.0 False True 16066423.677588826 23796985.026206095 12439348.098398108 1.0 1.4811625476676982 0.7742449936602784 23.937545490747162 -6.723431298270489 1.746847931569551 1.2916566520164936 0.77512088805719 0.5286801311206306 0.20239497715205892 0.3487100251763709 2.081313508065871 0.09192975767230856 0.22986247159786277 1.890465263217689e-07 6.723431298270489 -0.5165357639593036 LCPGGQLPFLLYGTEVHTDTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCPGGQLPFLLYGTEVHTDTNK 22 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 80183000.0 12255000.0 28683000.0 39245000.0 False True 16786004.678922415 27415690.218003087 29976139.27614602 1.0 1.6332469067179511 1.7857816585614317 24.000755552270054 -11.272257174082485 0.25920210447816167 5.068200853608319e-13 1.8514789289618159 0.9992739991319217 0.009166910759206438 3.46994168197997 0.14074157218876718 2.0615788296654545 0.06661469711117918 5.342479026881346e-12 11.272257174082485 1.851478928961309 LCPQSLFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCPQSLFSK 9 0 Q9NU22 Q9NU22 MDN1 Midasin 0 62034000.0 17663000.0 14728000.0 29643000.0 False True 23156364.04873534 12530639.809294347 26575826.715734392 1.0 0.5411315776052802 1.147668375734739 24.464905407147512 -6.70440198743315 1.8155288215304044 0.7162941161307811 1.145999725010306 0.4383544164502098 0.193542841441212 0.38642082062827404 2.4792654487863235 0.08495706380579104 0.2172788191420336 1.9751405833346936e-07 6.70440198743315 0.4297056088795249 LCPQSLFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCPQSLFSK 9 0 Q9NU22 Q9NU22 MDN1 Midasin 0 13789600.0 2250900.0 7119700.0 4419000.0 False True 3414779.8628323115 5849133.908529994 3545582.7130834926 1.0 1.7128875486803894 1.0383049143738037 21.703361146071803 -10.307724601839757 5.065099448220717 0.9998829753127983 1.375596231527187 0.2924578065392647 0.2753972072325869 0.0003640503223362031 4.975699229861978e-05 0.2667347770177685 0.08888406643360845 4.923516505296173e-11 10.307724601839757 0.37571325621438867 LCPQSLFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCPQSLFSK 9 0 Q9NU22 Q9NU22 MDN1 Midasin 0 58430000.0 17663000.0 17203000.0 23564000.0 False True 24193488.424627237 16442914.577286458 17998668.51581357 1.0 0.6796421536527468 0.7439468091543266 24.528115468670403 -10.778175032404617 7.043013960388791 1.0078956142546647 0.7117944814038559 0.9640067065987548 0.026252265677387608 0.003290019374005854 0.00010362148569358633 0.02569435575526996 0.008472882314061228 1.6665754022872236e-11 10.778175032404617 -0.29610113285080875 LCQGLFFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCQGLFFR 8 0 Q9Y4L1;A0A494C039;A0A087X054 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 66550000.0 19216000.0 20332000.0 27002000.0 False True 25192362.08800872 17298544.853515256 24208092.061473534 1.0 0.6866583130666087 0.960929823765764 24.586483062698594 -10.203439960897963 7.307727318308336 1.000000266058284 0.8237940690141383 0.3549735056108936 0.11197087536587123 4.852840277720476e-07 5.30567982468627e-08 0.10841549705303982 0.03613844462935715 6.259793965501012e-11 10.203439960897963 -0.17620619704414575 LCQGLFFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LCQGLFFR 8 0 Q9Y4L1;A0A494C039;A0A087X054 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 29752100.0 13479000.0 4277100.0 11996000.0 False True 13051116.523031572 5984968.334781849 8853887.727714038 1.0 0.4585790284087996 0.678400787556329 23.637669898848586 -10.24280531353238 5.555707060257569 1.0000268064369073 0.5684899079825487 0.837075832014339 0.08974185737879899 2.9799072375105363e-05 4.061282860017821e-06 0.08689756756989471 0.028964059923808592 5.717348777783185e-11 10.24280531353238 -0.4315368984543586 LCQGLFFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCQGLFFR 8 0 Q9Y4L1;A0A494C039;A0A087X054 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 56547000.0 19216000.0 14815000.0 22516000.0 False True 26320674.492874186 14160424.313346446 17198184.53157606 1.0 0.5379962552699821 0.653409719277222 24.649693124221486 -10.035977663741505 7.273478130996372 1.0000000393464135 0.595702987273617 0.9424017559196368 0.047117349377468566 3.007530040774772e-08 3.925489720125236e-09 0.04562118212273269 0.015207059121364308 9.204969127375229e-11 10.035977663741505 -0.4042970520727964 LCQGLFFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LCQGLFFR 8 0 Q9Y4L1;A0A494C039;A0A087X054 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 29920700.0 13479000.0 6455100.0 9986600.0 False True 11208385.720946267 6420325.095062972 12074751.887178674 1.0 0.5728144315255539 1.0772962483449637 23.418075174282862 -6.682295568843724 1.8936329147244904 0.730271416851866 1.0754150093430814 0.33465432034334763 0.18096171039496173 0.43347331045926213 3.007136551352535 0.07662371416012133 0.20150479903373314 2.078281784436454e-07 6.682295568843724 0.3451435924912154 LCQK(ub)FGQYNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCQKFGQYNK 10 1 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 5610030.0 655840.0 1018900.0 3935290.0 True False 859812.5911635954 866884.0916410936 3528103.94076721 1.0 1.0082244672271294 4.103340631465493 19.713662711853015 -6.907479805143087 0.9127090214855548 0.8963644274462041 4.4825197955886695 0.9899356707929394 0.14656858312825774 0.1061087214170839 0.14797520954484067 0.11852201515337468 0.3217406514995169 1.2374287294993296e-07 6.907479805143087 3.5861553681424656 up LCQK(ub)FGQYNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCQKFGQYNK 10 1 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 30207800.0 1082300.0 6256000.0 22869500.0 True False 1641928.2267286018 5139567.921648905 18349333.30094209 1.0 3.1302025496504458 11.175478320085604 20.64695963358615 -6.946195170359359 0.5991619654724346 0.909212271471849 13.807716724334975 0.9988678558566094 0.1474372550599546 0.0850505161420654 0.04256961240744741 0.15144628796656998 0.6759204154878116 1.1318915809652078e-07 6.946195170359359 12.898504452863126 LCQK(ub)FGQYNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCQKFGQYNK 10 1 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 9921440.0 655840.0 836800.0 8428800.0 True False 898321.7714095867 799827.4090724475 6438091.036585029 1.0 0.8903573691834403 7.166798402851581 19.776872773375906 -6.902927111064416 0.9425961972065021 0.7595902695056456 7.86617749040602 0.9879666366791737 0.32176684556724633 0.10928208219819187 0.16552527100720796 0.2545495793125031 0.6725564697166829 1.2504688825217572e-07 6.902927111064416 7.106587220900375 up LCQK(ub)FGQYNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCQKFGQYNK 10 1 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 23724100.0 1082300.0 3061800.0 19580000.0 True False 1401058.6853224966 2891408.1384614925 16016640.907765694 1.0 2.0637309263001686 11.431813010801166 20.4180859556786 -6.928354135531923 0.7601853691771965 0.8485007245999506 13.276802481514991 0.9962046797389463 0.2887506681068203 0.09350153478784677 0.0819346252462522 0.26053469692601794 0.8554502274769313 1.1793585624082388e-07 6.928354135531923 12.42830175691504 LCQK(ub)TMAPVAS ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCQKTMAPVAS 11 1 P35250;P35250-2;A0A087WVY3 P35250 RFC2 Replication factor C subunit 2 1 2602870.0 470600.0 673270.0 1459000.0 True False 644593.5374868121 643522.7051938412 1114414.249048209 1.0 0.9983387480160818 1.7288635151279486 19.298030198852786 -6.906386330948786 0.9199998576112499 0.9747158216723901 1.8163206004823054 0.9894846236152384 0.035273442930060406 0.10685650210339238 0.1520919204362578 0.028372404843981743 0.07649116106293817 1.2405482746346696e-07 6.906386330948786 0.8416047788099152 LCQLK(ub)GPTCQYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCQLKGPTCQYR 12 1 Q13444-2;Q13444-12;Q13444-9;Q13444-8;Q13444-7;Q13444-6;Q13444-5;Q13444-4;Q13444-3;Q13444;Q13444-11 Q13444-2 ADAM15 Disintegrin and metalloproteinase domain-containing protein 15 1 20793300.0 6968300.0 4737200.0 9087800.0 True False 9135508.781113196 4030428.2254609773 8147481.632333129 1.0 0.44118267761873403 0.8918476055955722 23.123053647990716 -10.00575763013974 7.062188824573505 1.0000000317357496 0.6665151416071586 0.42199934892416446 0.1839831864185651 9.192575857895465e-08 1.277978526840528e-08 0.17814097017231406 0.05938031808177297 9.86830059368863e-11 10.00575763013974 -0.33348489012859095 LCQLK(ub)GPTCQYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LCQLKGPTCQYR 12 1 Q13444-2;Q13444-12;Q13444-9;Q13444-8;Q13444-7;Q13444-6;Q13444-5;Q13444-4;Q13444-3;Q13444;Q13444-11 Q13444-2 ADAM15 Disintegrin and metalloproteinase domain-containing protein 15 1 6268700.0 2159100.0 1319300.0 2790300.0 True False 2090560.552331586 1846103.3700586134 2059436.7227943013 1.0 0.8830662034637881 0.9851122085401581 20.995458400452375 -10.170890799853037 5.026701861369661 1.0000044798763208 0.934089206932849 0.35742431204499603 0.04166010712142401 2.091735357955674e-06 3.449630524204753e-07 0.04033996683055202 0.013445741756827206 6.746976541243494e-11 10.170890799853037 -0.06591527294347177 LCQLK(ub)GPTCQYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCQLKGPTCQYR 12 1 Q13444-2;Q13444-12;Q13444-9;Q13444-8;Q13444-7;Q13444-6;Q13444-5;Q13444-4;Q13444-3;Q13444;Q13444-11 Q13444-2 ADAM15 Disintegrin and metalloproteinase domain-containing protein 15 1 68739700.0 5034700.0 32436000.0 31269000.0 True False 7638007.985873149 26647542.376375265 25088668.444310464 1.0 3.488807870541787 3.284713565462765 22.864764997686482 -10.411161003105398 5.344729786220839 0.998299319677851 3.386760718002286 0.9945458124357808 0.08332115114204744 0.0016889744703844952 0.0001860779216190029 0.08069706574881522 0.02689178589664675 3.8800649625608566e-11 10.411161003105398 2.3884613983244347 LCQLK(ub)GPTCQYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCQLKGPTCQYR 12 1 Q13444-2;Q13444-12;Q13444-9;Q13444-8;Q13444-7;Q13444-6;Q13444-5;Q13444-4;Q13444-3;Q13444;Q13444-11 Q13444-2 ADAM15 Disintegrin and metalloproteinase domain-containing protein 15 1 21320900.0 6968300.0 2861600.0 11491000.0 True False 9544668.821226852 2735165.049954247 8777062.464573672 1.0 0.2865646887476474 0.9195774760727096 23.186263709513607 -10.664623013772134 9.443976958490802 1.0002700350942422 0.6030710824102693 0.3439400636160477 0.25842638826722153 0.0014702608830260658 5.221206612470888e-05 0.25038186348814184 0.08340675816495675 2.1645966711565267e-11 10.664623013772134 -0.3971989526839729 LCQLK(ub)GPTCQYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCQLKGPTCQYR 12 1 Q13444-2;Q13444-12;Q13444-9;Q13444-8;Q13444-7;Q13444-6;Q13444-5;Q13444-4;Q13444-3;Q13444;Q13444-11 Q13444-2 ADAM15 Disintegrin and metalloproteinase domain-containing protein 15 1 43993700.0 5034700.0 20137000.0 18822000.0 True False 6517518.398774082 19016358.24815435 15396589.130028918 1.0 2.9177298911394325 2.3623391892418675 22.63589131977893 -10.181466317537424 9.26170829009203 0.9999999640539602 2.64003454019065 0.9208012404615582 0.2267373045892059 2.0145866623778318e-07 1.7660689277469963e-08 0.2195374544306649 0.07317915038649611 6.584664964754581e-11 10.181466317537424 1.64003457613669 LCQQVDITQK(ub)QLEEEIAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCQQVDITQKQLEEEIAR 18 1 Q8IWA4;Q8IWA4-3;H7C5H5 Q8IWA4 MFN1 Mitofusin-1 1 48549100.0 3742100.0 15843000.0 28964000.0 True False 4844222.217818835 14961323.122883717 23692849.195736736 1.0 3.0884881927692036 4.890950111368901 22.207833616270513 -7.364070878541636 0.21950410419495187 7.269647956730306e-14 7.323840183471777 0.9999548714330897 0.010680621735469376 0.12038905448417567 0.01668910239644102 0.14033664014918223 0.35102800363566355 4.3244324886229044e-08 7.364070878541636 7.323840183471704 LCQSFQTFSICYAETGLLGAHFVCDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCQSFQTFSICYAETGLLGAHFVCDR 26 0 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 42372000.0 12968000.0 12030000.0 17374000.0 False True 19673404.087791316 9883152.509180995 13940021.284705296 1.0 0.5023610792051063 0.7085718985132841 24.229743272853426 -10.232246849151284 5.526236382214034 1.0000225578914623 0.6054664888591744 0.8299527105694282 0.08418521445779045 2.3398622001074312e-05 3.2507671560966585e-06 0.08151663662995222 0.027170661132649418 5.858051034168835e-11 10.232246849151284 -0.3945560690322879 LCSAHGVLVPGGFGVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCSAHGVLVPGGFGVR 16 0 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 46747000.0 14973000.0 18921000.0 12853000.0 False True 19629747.998738237 16098060.553480325 11523094.854681851 1.0 0.8200849320386119 0.5870220471206525 24.226538316215606 -6.96757958491594 0.31061252622960306 1.03564655001539 0.3640455112632464 0.999956870633546 0.0011102669759451662 0.07709620913642119 0.011827525443701574 0.0036773614241373837 0.020679287774640266 1.077507781178689e-07 6.96757958491594 -0.6716010387521436 LCSAHGVLVPGGFGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LCSAHGVLVPGGFGVR 16 0 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 21936900.0 10477000.0 3163100.0 8296800.0 False True 10144413.369819852 4426142.325348586 6123619.181335254 1.0 0.43631328535138225 0.6036444847124757 23.274182103685412 -10.877556289146257 11.160444814502554 1.0206411581988062 0.5199788850319802 0.9164752520735732 0.06831267608043423 0.028560218110675682 0.0003133398911414501 0.05384302244137633 0.022047821399531955 1.3256952825315027e-11 10.877556289146257 -0.500662273166826 LCSAHGVLVPGGFGVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCSAHGVLVPGGFGVR 16 0 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 43621000.0 14973000.0 14802000.0 13846000.0 False True 20508922.730110563 14147998.696331684 10575859.967321128 1.0 0.6898460188530542 0.5156711596457467 24.289748377738498 -11.687430779285759 0.08758096558324506 2.1483064552173534 4.1911640013426567e-14 0.9999138848068047 0.0018588073178226994 4.879942971697727 0.06144580685196476 1.4373211153039365 0.36581846477829705 2.053852356883135e-12 11.687430779285759 -2.1483064552173117 LCSAHGVLVPGGFGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LCSAHGVLVPGGFGVR 16 0 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 19796200.0 10477000.0 4881400.0 4437800.0 False True 8712089.709797021 4855102.929317966 5365723.46193115 1.0 0.5572833948046069 0.6158939635225776 23.05458737911969 -10.276782132732299 5.577522325651643 1.0000382488660344 0.5865886791638298 0.9851491801571055 0.0239276644822601 1.1381566720337687e-05 1.4758187407794786e-06 0.023169999131453147 0.007722620504447763 5.287104170280953e-11 10.276782132732299 -0.4134495697022046 LCSAHGVLVPGGFGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCSAHGVLVPGGFGVR 16 0 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 34545000.0 15890000.0 0.0 18655000.0 False True 20569918.238727264 0.0 15259981.4164642 1.0 0.0 0.7418591187073377 24.294032723664216 -10.719837189207835 9.320880473688351 1.0015393423055625 0.37092956068755645 0.48946401814514406 0.3028627169772986 0.009701243732460903 0.00029159499954742573 0.2936424442103163 0.09774852158668403 1.9061751818568544e-11 10.719837189207835 -0.6306097816180061 LCSGPGIVGNVLVDPSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCSGPGIVGNVLVDPSAR 18 0 Q9Y5P6;Q9Y5P6-2 Q9Y5P6 GMPPB Mannose-1-phosphate guanyltransferase beta 0 4918300.0 1055200.0 2116800.0 1746300.0 False True 1383377.4185713374 1800981.6912217732 1565609.6276924403 1.0 1.3018729863913137 1.1317299289945766 20.399763381357143 -10.195450420523631 3.8471697082760756 0.9998345139970807 1.2168014576944177 0.6840326654862658 0.06946061281166767 8479734.452103293 5618087.586284616 11266.12836242263 0.02377821551926264 6.376018661233981e-11 10.195450420523631 0.21696694369733704 LCSLFYTNEEVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCSLFYTNEEVAK 13 0 P43243;A8MXP9;A0A0R4J2E8;P43243-2;B3KM87;Q68E03 P43243 MATR3;DKFZp686L22104 Matrin-3 0 26645600.0 6215900.0 7482700.0 12947000.0 False True 8149105.094861233 6366310.327336154 11607368.636393525 1.0 0.7812281536718312 1.4243734129423669 22.9582102058343 -6.814926063781778 1.3937676255377611 0.8814439772322881 1.4369330533859752 0.8722824122664339 0.09541854787241465 0.20016614370737626 0.765383898606497 0.053816986499368225 0.12423321709529948 1.531348142989353e-07 6.814926063781778 0.5554890761536871 LCSLFYTNEEVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LCSLFYTNEEVAK 13 0 P43243;A8MXP9;A0A0R4J2E8;P43243-2;B3KM87;Q68E03 P43243 MATR3;DKFZp686L22104 Matrin-3 0 8651000.0 5206600.0 0.0 3444400.0 False True 5041319.332948745 0.0 2542208.3102149186 1.0 0.0 0.5042744056302305 22.26536991138622 -9.393261734334512 10.02580613583076 1.000000000031552 0.252137192604073 0.7457135182800914 0.2058691640232257 0.0 0.0 0.1993319609398978 0.06644398697996592 4.0433214119164095e-10 9.393261734334512 -0.7478628074274791 LCSLFYTNEEVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCSLFYTNEEVAK 13 0 P43243;A8MXP9;A0A0R4J2E8;P43243-2;B3KM87;Q68E03 P43243 MATR3;DKFZp686L22104 Matrin-3 0 22190100.0 6215900.0 8273200.0 7701000.0 False True 8514086.208381385 7907662.668186138 5882182.407073525 1.0 0.9287740897433862 0.6908765383750781 23.02142026735719 -6.949015827528223 0.5695523799067612 1.002969469945745 0.6051237754665055 0.999121718858708 0.003917029181967786 0.08388349935086539 0.03761758164065372 0.004151973339207464 0.019819340263206565 1.1245639893508139e-07 6.949015827528223 -0.39784569447923945 LCSVHFQGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCSVHFQGGR 10 0 Q96EK4 Q96EK4 THAP11 THAP domain-containing protein 11 0 5904300.0 1275700.0 2271700.0 2356900.0 False True 1672455.053896375 1932771.2150172435 2113030.5969812237 1.0 1.1556491222376357 1.263430423471426 20.673536009253922 -6.975045881357348 0.06489640602471208 0.48861498358524774 1.9331517007157824 0.9999999546743897 2.228607938764958e-05 0.07469624427289731 0.0018688751109689882 0.016774186495248432 0.024712939530087352 1.0591418254557612e-07 6.975045881357348 1.4445367171305346 LCSVHFQGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCSVHFQGGR 10 0 Q96EK4 Q96EK4 THAP11 THAP domain-containing protein 11 0 3867900.0 1275700.0 1116500.0 1475700.0 False True 1747360.764496233 1067169.3382282343 1127170.052995507 1.0 0.6107321166364297 0.6450700255481997 20.736746070776814 -9.985606754475981 5.99685166888322 1.0000003072505101 0.6279010716096927 0.993653603560465 0.014018392611521971 5.7584698053469834e-08 9.713458182084409e-09 0.013573261607330661 0.004524416760390947 1.0336969753890327e-10 9.985606754475981 -0.3720992356408175 LCTFILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCTFILK 7 0 P55010;H0YLZ1;H0YN40 P55010 EIF5 Eukaryotic translation initiation factor 5 0 9045500.0 2799500.0 2010500.0 4235500.0 False True 3670171.610396567 1710541.2368676192 3797251.0897848783 1.0 0.46606573709581745 1.034624942067649 21.807416091705953 -10.161735975116759 13.875239716093642 1.00002361520362 0.7503453395817247 0.20450508151475355 0.23211332385767836 0.0 0.0 0.22474275925247342 0.07491425308415779 6.890710827418191e-11 10.161735975116759 -0.24967827562189526 LCTFILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCTFILK 7 0 P55010;H0YLZ1;H0YN40 P55010 EIF5 Eukaryotic translation initiation factor 5 0 8179700.0 2799500.0 2740500.0 2639700.0 False True 3834550.8036428653 2619415.6483783973 2016257.2263280037 1.0 0.6831088652913201 0.5258131472433583 21.870626153228844 -13.99999999998174 0.0912764961200373 2.6138572007359424 0.1403944602911844 0.9998363920619393 0.002522453606006882 12.152361076925336 0.08809196009453923 3.7891511876358157 0.3458993868637939 1.0000000000420433e-14 13.99999999998174 -2.473462740444758 LCTLALHVLPNSSIGILATTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCTLALHVLPNSSIGILATTR 21 0 Q8WTT2 Q8WTT2 NOC3L Nucleolar complex protein 3 homolog 0 109309000.0 34645000.0 35186000.0 39478000.0 False True 52558997.88876696 28906783.390527245 31675155.996177886 1.0 0.5499873390224069 0.602659054938861 25.647434433123514 -10.40193505701052 6.813416159570821 1.0000356588969992 0.5763231969818954 0.9885411350360965 0.021503137978690603 1.1648625062389242e-05 1.0224717799997093e-06 0.02082206962204408 0.006940107940222413 3.963372968193864e-11 10.40193505701052 -0.4237124619151038 LCTQLEGLQSTVTGHVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCTQLEGLQSTVTGHVER 18 0 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 0 11552000.0 3443300.0 4106600.0 4002100.0 False True 4514199.6449646335 3493911.2874014224 3588001.0828539855 1.0 0.7739824469878526 0.7948255205895076 22.10603879388653 -10.759872755860574 6.9094699841221825 1.0047259458921147 0.7844039837886893 0.9930390287218556 0.008509149165888146 0.0006295038862597369 2.1877332246067898e-05 0.008372375853804336 0.002746316084156631 1.7383100624078286e-11 10.759872755860574 -0.22032196210342547 LCTQLEGLQSTVTGHVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCTQLEGLQSTVTGHVER 18 0 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 0 7093100.0 3443300.0 3649800.0 0.0 False True 4716381.061683684 3488539.7677253983 0.0 1.0 0.739664527123692 0.0 22.16924885540942 -7.352856909386542 0.786539085774844 0.989494154055684 7.356296702183982e-23 0.9877987043438551 0.04678984424255723 0.10914923496469585 0.13795315077571188 0.040201262118089436 0.07159900949947183 4.437548274401126e-08 7.352856909386542 -0.989494154055684 down LCYVALDFEQEMATAASSSSLEK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LCYVALDFEQEMATAASSSSLEK 23 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L4N8;Q6S8J3 P60709;P63261;Q6S8J3 ACTB;ACTG1;POTEE Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member E 0 38842600.0 27417700.0 3791200.0 7633700.0 False True 26547340.121190224 5305045.930846825 5634204.963908845 1.0 0.19983342612212626 0.2122323719886194 24.662063983387732 -10.084827744965636 5.144296184112695 1.0000154514917128 0.20603289905550032 0.9998171281260534 0.0050618484600124265 5811433.422113544 11392677.747621179 697.3631887610219 0.001732805163845865 8.225688422753253e-11 10.084827744965636 -0.7939825524362125 LCYVALDFEQEMATAASSSSLEK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LCYVALDFEQEMATAASSSSLEK 23 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L4N8;Q6S8J3 P60709;P63261;Q6S8J3 ACTB;ACTG1;POTEE Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member E 0 552697000.0 69375000.0 354507000.0 128815000.0 False True 105246946.99186629 291242456.0741665 103354658.7883797 1.0 2.767229495946085 0.9820204931585063 26.64920314323544 -6.648555511718649 2.014500570095182 2.148099785247533 0.9896326539344578 0.1879918021018141 0.7545485844368427 0.5120108722424104 3.9813860040456643 0.30400457122593194 0.8352933626272095 2.2461796499351947e-07 6.648555511718649 -1.1584671313130752 LCYVALDFEQEMATAASSSSLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCYVALDFEQEMATAASSSSLEK 23 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L4N8;Q6S8J3 P60709;P63261;Q6S8J3 ACTB;ACTG1;POTEE Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member E 0 4919270.0 2966600.0 1040500.0 912170.0 False True 4063432.189350569 994527.2695266252 696734.2327308474 1.0 0.24475055154927386 0.17146446655535347 21.954267388058263 -13.999999999999998 0.32984982420207126 9.213958785879166 0.15846272160205016 0.999714530288956 0.0063274713853772495 18.810557628847437 0.18364615066276743 107.1807862607954 0.02349787279066267 1.0000000000000041e-14 13.999999999999998 -9.055496064277117 LCYVALDFEQEMATAASSSSLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LCYVALDFEQEMATAASSSSLEK 23 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L4N8;Q6S8J3 P60709;P63261;Q6S8J3 ACTB;ACTG1;POTEE Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member E 0 25239000.0 17695000.0 1911500.0 5632500.0 False True 14714176.521414349 1901202.3700969575 6810229.708262466 1.0 0.1292088869078085 0.4628345798591695 23.81070346835086 -10.536750027621473 6.26980087620472 1.0008771506081315 0.2960217336696002 0.8558372882572727 0.13620211880221486 0.0016718003704093338 0.00012352233940293107 0.13202017712880135 0.043959044819928496 2.9056946407217825e-11 10.536750027621473 -0.7048554169385313 LCYVALDFEQEMATAASSSSLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LCYVALDFEQEMATAASSSSLEK 23 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L4N8;Q6S8J3 P60709;P63261;Q6S8J3 ACTB;ACTG1;POTEE Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member E 0 225201700.0 69375000.0 93805000.0 62021700.0 False True 89807305.08569558 88584669.2887779 50734386.99638257 1.0 0.9863860095150275 0.5649249462276037 26.42032946532789 -6.913775626244988 0.8696189568196573 1.0115432601899517 0.5058173881103638 0.9922702669877861 0.017756450748728798 0.10197421739887821 0.12561277970170795 0.014814462546726168 0.04204838042570764 1.219619540013391e-07 6.913775626244988 -0.5057258720795879 LCYVGYNIEQEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCYVGYNIEQEQK 13 0 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 0 14996700.0 3552400.0 6371400.0 5072900.0 False True 4657230.801490539 5420811.955522679 4548004.97069288 1.0 1.1639560473978994 0.9765470436288661 22.15104094985367 -6.675586012667997 1.917785705010363 1.104148108990434 0.9772871164899258 0.30389994083815464 0.06955707238954059 0.44843343430523613 3.1848319490235784 0.02914592715346534 0.07730177877064696 2.1106391391912116e-07 6.675586012667997 -0.12686099250050809 LCYYIGATDDAATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LCYYIGATDDAATK 14 0 P55145 P55145 MANF Mesencephalic astrocyte-derived neurotrophic factor 0 44990000.0 11307000.0 16291000.0 17392000.0 False True 14823586.497143755 13860446.301820638 15592442.675844299 1.0 0.935026506877489 1.0518670821564464 23.821391207378472 -6.755749690640854 1.6283578171202941 0.9620623939259271 1.0522086243615774 0.6734782307665357 0.02731385503981472 0.29008841194333856 1.5149279275050804 0.013241020937337384 0.03195664663497769 1.7548916573167143e-07 6.755749690640854 0.09014623043565029 LCYYIGATDDAATK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LCYYIGATDDAATK 14 0 P55145 P55145 MANF Mesencephalic astrocyte-derived neurotrophic factor 0 9409100.0 5727800.0 1397900.0 2283400.0 False True 5545974.124239202 1956088.7599521985 1685309.0394683413 1.0 0.3527042709057961 0.3038797155764827 22.403009454558603 -13.999999999999998 0.3666348582992645 9.827878417026353 0.2985482894950634 0.9997850848739358 0.004651212544180803 22.431932704889434 0.19624343077641884 155.40842971357668 0.013791035372110435 1.0000000000000041e-14 13.999999999999998 -9.52933012753129 LCYYIGATDDAATK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LCYYIGATDDAATK 14 0 P55145 P55145 MANF Mesencephalic astrocyte-derived neurotrophic factor 0 36278500.0 5857800.0 23436800.0 6983900.0 False True 8886710.86254348 19254319.927445788 5603529.103847887 1.0 2.166641879685841 0.6305515269396412 23.08321811882504 -6.7036444152082195 1.8179514355990594 1.7218345742677408 0.6348054588938281 0.43487518961356064 0.49213296030006193 0.38797789608597444 2.495333879970657 0.2157653163197344 0.5523926483243297 1.9785889749947132e-07 6.7036444152082195 -1.0870291153739127 LCYYIGATDDAATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LCYYIGATDDAATK 14 0 P55145 P55145 MANF Mesencephalic astrocyte-derived neurotrophic factor 0 30811800.0 11307000.0 9297800.0 10207000.0 False True 15487503.46018569 8886992.452287033 7796316.819763594 1.0 0.5738169792912822 0.5033940324730761 23.884601268901363 -13.999999999999998 0.25333758230484166 4.014483875108136 0.4759636602956107 0.9995490616256595 0.004658924443153306 14.132770203058591 0.1592667623196103 21.72345786410183 0.03190764630986174 1.0000000000000041e-14 13.999999999999998 -3.5385202148125257 LCYYIGATDDAATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LCYYIGATDDAATK 14 0 P55145 P55145 MANF Mesencephalic astrocyte-derived neurotrophic factor 0 27210700.0 5857800.0 15064000.0 6288900.0 False True 7583037.574500716 14225675.157679746 5144384.7295632195 1.0 1.875986373259715 0.6784068625562543 22.85434444091749 -6.710631010253584 1.7931379925327147 1.5381875767197173 0.6811873041924704 0.4680613715568428 0.36909846460114365 0.3737848478492699 2.343225340597481 0.16378832153387846 0.4157528150568502 1.947013620821144e-07 6.710631010253584 -0.8570002725272469 LDADKYENDPELEK(ub)IR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDADKYENDPELEKIR 16 2 Q9BV57 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 16225100.0 4116100.0 6377100.0 5731900.0 True False 5396246.960369102 5425661.537741108 5138817.972267249 1.0 1.0054509323957987 0.9522948097089602 22.36352494436107 -6.881616944977002 1.0707779748307804 1.0034560391634741 0.9484094591216314 0.9749648217369618 0.0037779622708307334 0.1262057157858542 0.2637332608232913 0.002713884916635159 0.006590462935247992 1.3133577919218232e-07 6.881616944977002 -0.05504658004184271 LDADKYENDPELEK(ub)IR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDADKYENDPELEKIR 16 2 Q9BV57 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 18652800.0 5350000.0 3852000.0 9450800.0 True False 5180167.178441941 5390123.687914634 6975351.962077336 1.0 1.040530836600498 1.3465495845590336 22.304567227779863 -6.931188163196263 0.7369654874504005 0.9955457056611487 1.4113196483943422 0.9967668510536801 0.008796321373053383 0.09202518638186172 0.07468959654497558 0.008071327876115881 0.027510640281248187 1.1716876081122551e-07 6.931188163196263 0.41577394273319346 LDADKYENDPELEK(ub)IR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDADKYENDPELEKIR 16 2 Q9BV57 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 50237100.0 7644100.0 14687000.0 27906000.0 True False 11596658.558566127 12065990.099945243 22390366.86836571 1.0 1.0404712736008284 1.9307602060790667 23.467205833751386 -6.916406208931101 0.850956297499701 0.9776990250360648 2.0630949637401796 0.9931229912341921 0.03562104966472462 0.10033264513407501 0.11691303165892761 0.030120832862182846 0.08734622300693921 1.212254461304936e-07 6.916406208931101 1.085395938704115 LDADKYENDPELEK(ub)IR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDADKYENDPELEKIR 16 2 Q9BV57 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 19078000.0 4116100.0 6807300.0 8154600.0 True False 5637933.403420036 6506530.977269197 6228651.429258763 1.0 1.1540631135022381 1.1047756302833216 22.426735005883963 -10.087190309567097 4.268779278087372 0.9999842518753781 1.1294193719087344 0.9018948271257226 0.020121530834191426 13988560.23841526 0.012759131199595963 2257.893463322072 0.006888135195706016 8.18106212183922e-11 10.087190309567097 0.12943512003335633 LDADKYENDPELEK(ub)IR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDADKYENDPELEKIR 16 2 Q9BV57 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 16511600.0 5350000.0 6519600.0 4642000.0 True False 4448762.0451860335 6484477.620760724 5612620.737817028 1.0 1.4575914726159653 1.2616140582053372 22.08497250321414 -10.174150802991319 4.545854282647746 0.9999375941782231 1.3596027654145832 0.8178253871443053 0.08000744442366532 56100968.219579265 4.334706621164467 37190.62030375233 0.02738867629633466 6.696520412625533e-11 10.174150802991319 0.3596651712363601 LDADKYENDPELEK(ub)IR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDADKYENDPELEKIR 16 2 Q9BV57 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 52502100.0 7644100.0 10103000.0 34755000.0 True False 9895438.137737881 9540759.168749245 28429946.616414562 1.0 0.9641573254208917 2.8730356575109375 23.238332155843835 -6.902621851163378 0.9445411680722283 0.9262436812882033 3.084426488949135 0.9878262466160829 0.0983662577441355 0.1095011279749335 0.16673422253216794 0.07770460982770605 0.20496844308014228 1.2513481296846192e-07 6.902621851163378 2.158182807660932 up LDAK(ub)IDSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDAKIDSK 8 1 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 9334700.0 1984000.0 3154300.0 4196400.0 True False 2601043.2130833296 2683690.735365102 3762196.7827111874 1.0 1.0317747593988646 1.4464184077324123 21.310658937379834 -6.92221772290405 0.8080892656582392 0.9915623594394478 1.5168221513152431 0.9947756718591475 0.014699368577499525 0.09688378886740981 0.09897427582423064 0.012816209754659484 0.039244938597178466 1.1961407251077733e-07 6.92221772290405 0.5252597918757953 LDAK(ub)IDSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDAKIDSK 8 1 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 10038000.0 1821100.0 2790300.0 5426600.0 True False 1763290.1773197425 3904481.3412222713 4005210.665489572 1.0 2.214315823591332 2.271441602185762 20.749838481833418 -10.815068533477342 0.5541228460188949 5.918519158008243e-15 2.266435132993927 0.9998332286776763 0.007572282906660117 2.453493442688726 0.2696605368361483 3.252943795214058 0.010592592437708433 1.530845868768886e-11 10.815068533477342 2.266435132993921 LDAK(ub)IDSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDAKIDSK 8 1 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 49832100.0 1465100.0 11135000.0 37232000.0 True False 2222663.8131572357 9147872.251847913 29873078.880634658 1.0 4.115724653317499 13.440214711644012 21.083858320761834 -6.9515053212441 0.5420664610014229 0.8645545969251769 17.12351707993718 0.999314178239601 0.13841337714314242 0.08288686766926646 0.03350398648512154 0.1518106067119143 0.7724589319620799 1.118136124406221e-07 6.9515053212441 16.258962483012002 LDAK(ub)IDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDAKIDSK 8 1 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 5548700.0 1984000.0 0.0 3564700.0 True False 2717538.4155840105 0.0 2722791.277300995 1.0 0.0 1.001932948467945 21.373868998902726 -12.024904224243008 14.361424132413761 0.8748023269342919 0.5508698268105886 0.0 0.486015575291834 0.0 0.0 0.0 0.13935917593301186 9.442690947174573e-13 12.024904224243008 -0.32393250012370334 LDAK(ub)IDSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDAKIDSK 8 1 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 10070200.0 1821100.0 3162600.0 5086500.0 True False 1514325.3384090257 3145562.4460730543 6150063.632681229 1.0 2.077203865173274 4.06125650591212 20.530243757267694 -6.961623721347502 0.411917938542227 0.904284640340116 5.308035616529452 0.9998257466354589 0.01673691549608195 0.07912620422719618 0.01902573941272152 0.025563422410983225 0.16555205958990107 1.0923863849928549e-07 6.961623721347502 4.403750976189336 LDAK(ub)IDSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDAKIDSK 8 1 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 25884600.0 1465100.0 2664500.0 21755000.0 True False 1896600.831438595 2516218.2327162568 17795813.225150283 1.0 1.3266988978422383 9.383004019697673 20.854984642854284 -6.915436661464518 0.857876459936552 0.7913661500690528 10.554992755335254 0.9928167808658948 0.3285973024851747 0.10093210276330185 0.12007396620889313 0.27647907400366895 0.7952780603893107 1.2149638007479771e-07 6.915436661464518 9.763626605266202 up LDAQVK(ub)ELVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDAQVKELVLK 11 1 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 1 5135400.0 1204900.0 1011000.0 2919500.0 True False 1579635.5682681988 860162.7408471331 2617418.1458214982 1.0 0.5445323960324311 1.6569759496432783 20.591160327412602 -6.795536657338628 1.4740965458593158 0.7472602823732015 1.6706878515785266 0.8187845944643013 0.19438467352592012 0.22719046113412258 0.9750385219110959 0.10376380858848773 0.24199868600262925 1.6012654851983864e-07 6.795536657338628 0.9234275692053251 LDAQVK(ub)ELVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDAQVKELVLK 11 1 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 1 4476890.0 1204900.0 907690.0 2364300.0 True False 1650384.0911981736 867585.2544705649 1805901.034286967 1.0 0.5256868744055214 1.094230757505599 20.654370388935494 -6.685318587562745 1.8828772244287968 0.7013402290380394 1.0921702393014383 0.3486359235758142 0.20079601585786042 0.4268385917736397 2.9300439981696984 0.08542811731093862 0.22379668509451453 2.063865600206893e-07 6.685318587562745 0.3908300102633989 LDCCGLTHACYLK(ub)ISQILTTSPSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDCCGLTHACYLKISQILTTSPSLK 25 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 95352000.0 17912000.0 25756000.0 51684000.0 True False 27173813.54260626 21159640.56745349 41468634.74609806 1.0 0.7786776241132642 1.5260513464949892 24.695713710188482 -6.827369183904831 1.3395424349352296 0.8815051790237227 1.5451141951015666 0.9005218296455975 0.09886391603967196 0.18408288338219653 0.6469137201578147 0.05796194075599204 0.13341533140979808 1.4880955435612594e-07 6.827369183904831 0.6636090160778438 LDCCGLTHACYLK(ub)ISQILTTSPSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDCCGLTHACYLKISQILTTSPSLK 25 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 61371000.0 17912000.0 14441000.0 29018000.0 True False 23187437.09830601 13637345.655340783 23737021.74982355 1.0 0.5881351008101312 1.0237018282437818 24.46684003228093 -11.025903756736096 12.997998221301152 1.421387076489057 0.8059184645157659 0.20931535403583024 0.17781937185772723 0.04412808445843175 8.7943094939679e-05 0.0034989850607580176 0.057390955486503435 9.420983502095259e-12 11.025903756736096 -0.6154686119732912 LDCNAK(ub)QWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDCNAKQWR 9 1 H3BR29;H3BSM7;Q96GQ5;I3L2V0 H3BR29 C16orf58 RUS1 family protein C16orf58 1 5697640.0 728140.0 1273900.0 3695600.0 True False 954598.5913177914 1083839.085623309 3313214.7626983756 1.0 1.1353872669423337 3.470793685254232 19.86453468187204 -6.918810002459375 0.8335044334474736 0.9462273416017559 3.8372809105206995 0.9938439293393132 0.08898846258775979 0.0988771040417785 0.1092796161142306 0.0761933604525326 0.22570262098820393 1.2055632414632944e-07 6.918810002459375 2.8910535689189434 up LDCNAK(ub)QWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDCNAKQWR 9 1 H3BR29;H3BSM7;Q96GQ5;I3L2V0 H3BR29 C16orf58 RUS1 family protein C16orf58 1 24390000.0 1969000.0 11986000.0 10435000.0 True False 2987116.9531817595 9847004.652954556 8372517.6761770155 1.0 3.296491167667846 2.802875751904839 21.510322293237436 -10.023340565963801 5.43380082091873 0.9999898909330737 3.049683459788755 0.9583155905529988 0.20151764964033242 2.4679600414703635e-05 4.4358203184840295e-06 0.19511958732293197 0.06503954175076179 9.476750220425922e-11 10.023340565963801 2.049693568855681 LDCNAK(ub)QWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDCNAKQWR 9 1 H3BR29;H3BSM7;Q96GQ5;I3L2V0 H3BR29 C16orf58 RUS1 family protein C16orf58 1 10625540.0 728140.0 1259900.0 8637500.0 True False 997353.0352436209 1204233.4520678495 6597500.3948964495 1.0 1.2074294753348742 6.615010093476975 19.927744743394932 -6.914998842066728 0.8609854303653428 0.8578611154782533 7.394093579172189 0.9926754818743414 0.22246799272120116 0.10120477960087255 0.12151859345616815 0.18676491949059484 0.5352986988851467 1.21618924329432e-07 6.914998842066728 6.536232463693936 up LDCNAK(ub)QWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDCNAKQWR 9 1 H3BR29;H3BSM7;Q96GQ5;I3L2V0 H3BR29 C16orf58 RUS1 family protein C16orf58 1 21141000.0 1969000.0 8472000.0 10700000.0 True False 2548909.3147925683 8000525.752513472 8752709.79127135 1.0 3.1388036075204813 3.433903960598006 21.281448615329886 -10.137960295384534 0.44812089782669073 4.644050578957909e-24 3.442766954568583 0.999174735560159 0.03115516386459514 1.4635753361706922 0.20537731154452463 1.9474008651843313 0.0665148900250831 7.278463435775451e-11 10.137960295384534 3.442766954568583 LDDLVSTGK(ub)LNLSQVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDDLVSTGKLNLSQVR 16 1 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 1 28597600.0 4461900.0 9090700.0 15045000.0 True False 5776017.507198058 8584794.553632464 12306964.37473621 1.0 1.4862826407527532 2.1307006703839284 22.461643684386782 -6.967234428014079 0.31737229884136986 0.9089811116984108 2.728707512760303 0.9999520732611522 0.003206058515538846 0.07721068411959081 0.012227936253939716 0.009874285136781227 0.05681800886717034 1.0783644742525517e-07 6.967234428014079 1.8197264010618923 LDDNEALIEK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDDNEALIEKLK 12 1 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 1 22968600.0 6222300.0 7314000.0 9432300.0 True False 6024776.4924148265 10234518.342006132 6961697.667065443 1.0 1.6987382610610295 1.1555113581109933 22.522476290456673 -10.260238917455723 3.79776455514253 0.9993414697616235 1.4271248097214038 0.4518448219472655 0.22177145492981074 14038292.797670612 10836553.763458205 69088.28952810694 0.07591826827233718 5.492386393024976e-11 10.260238917455723 0.42778333995978024 LDDNEALIEK(ub)LK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDDNEALIEKLK 12 1 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 1 9702400.0 2849100.0 2567500.0 4285800.0 True False 3902489.2640324626 2454059.3604128924 3273582.308821669 1.0 0.6288446154178782 0.8388446674262107 21.895963232597587 -10.157854489203267 5.302861467056871 1.000009106557529 0.7338446414219325 0.6817068465472618 0.08573216223011602 9.230464192922722e-06 1.465902669787246e-06 0.08301264818227057 0.027669936379242754 6.95257225191254e-11 10.157854489203267 -0.26616446513559644 LDDNEALIEK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDDNEALIEKLK 12 1 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 1 18913100.0 6222300.0 7235100.0 5455700.0 True False 5174118.14462824 7196123.080245093 6596461.645693305 1.0 1.3907921850829974 1.2748958298414077 22.30288156589095 -10.24401540254332 5.673442922151404 0.9999828919511855 1.3328440074622088 0.9166469599029312 0.04731448889839677 1.0239296446643298e-05 1.3643766802059632e-06 0.04581440915277389 0.015270685628146876 5.701440513833104e-11 10.24401540254332 0.33286111551102326 LDDTGNPICSCQPVHTFFGGPTCK(ub)LLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDDTGNPICSCQPVHTFFGGPTCKLLTK 28 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 31442600.0 6743800.0 9485800.0 15213000.0 True False 8841187.107052088 8070555.6153588 13638904.693400394 1.0 0.9128361969538455 1.5426553615771181 23.075808662750177 -6.871902679555997 1.1239119298850675 0.9500820900562109 1.5809106893902167 0.9665489711499174 0.05096155829587334 0.1350471743595647 0.3176590548160732 0.03514603210780087 0.08350018049177592 1.3430658931794367e-07 6.871902679555997 0.6308285993340058 LDDTGNPICSCQPVHTFFGGPTCK(ub)LLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDDTGNPICSCQPVHTFFGGPTCKLLTK 28 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 148169000.0 24788000.0 21341000.0 102040000.0 True False 37605208.24554065 17532531.812005945 81871749.27427931 1.0 0.4662261593534723 2.1771385692030556 25.164429150307495 -6.822874390853319 1.3593006792647657 0.7130959380303235 2.216868569885778 0.8908751724523841 0.23611041426412643 0.18978046910689658 0.6882092556359144 0.1364656612803348 0.3143305863493535 1.5035767763266807e-07 6.822874390853319 1.5037726318554545 up LDDTGNPICSCQPVHTFFGGPTCK(ub)LLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDDTGNPICSCQPVHTFFGGPTCKLLTK 28 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 47882800.0 6743800.0 12233000.0 28906000.0 True False 9237165.104342457 11692505.610878635 22078998.137757093 1.0 1.2658110447091506 2.390235303619029 23.13901872427307 -6.943591034312865 0.6252620138305505 0.987725910210964 2.7284306567551093 0.998597451415844 0.022566354711716925 0.08616587398389913 0.04743115101182483 0.022618165113162888 0.0953526938911736 1.1386990693044174e-07 6.943591034312865 1.7407047465441452 up LDDTGNPICSCQPVHTFFGGPTCK(ub)LLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDDTGNPICSCQPVHTFFGGPTCKLLTK 28 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 109708000.0 24788000.0 18486000.0 66434000.0 True False 32088554.64452934 17457237.84950002 54343693.67040385 1.0 0.5440331620693998 1.6935538004878232 24.935555472399944 -6.799092126803641 1.459705675336359 0.7481299222637444 1.7090516323766949 0.8294616261092741 0.19517421271005395 0.2220622896844872 0.934234737968533 0.1051939511919687 0.24476918718902207 1.5882098062252183e-07 6.799092126803641 0.9609217101129505 LDDTVHVVIATPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDDTVHVVIATPGR 14 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 13610100.0 2535900.0 5340300.0 5733900.0 False True 3324589.4576905356 4543548.056326357 5140611.031452597 1.0 1.3666493605146017 1.546239346804517 21.664744767405004 -11.501267249364176 0.1225568977946882 1.884708407482199e-21 1.8690837413748433 0.9997685306704005 0.0034584394268163806 4.352420297415248 0.08049589250123425 1.4014719135794371 0.2316586566419572 3.1530637430766247e-12 11.501267249364176 1.8690837413748433 LDDTVHVVIATPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDDTVHVVIATPGR 14 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 11377200.0 2987300.0 3036600.0 5353300.0 False True 2892469.7966653444 4249130.215659808 3951110.134442434 1.0 1.4690318358928152 1.365998752691409 21.463870464031658 -10.077106549745228 4.765462041080963 0.9999864948131202 1.4175152942819247 0.9563209141568569 0.04206308014011775 7.4624340445906184e-06 1.4452928668957652e-06 0.040729029721909345 0.013575800730265675 8.373238280182988e-11 10.077106549745228 0.4175287994688045 LDDTVHVVIATPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDDTVHVVIATPGR 14 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 57643700.0 9888700.0 32735000.0 15020000.0 False True 15001880.86080676 26893183.49027759 12051290.416500147 1.0 1.7926541171605697 0.803318632397942 23.838640054162582 -6.69338129881808 1.854601340193835 1.495360323750181 0.8066084215381073 0.3862538876844588 0.3350098190174557 0.4094146111730747 2.7328550179742646 0.14437486492879864 0.3743399758432205 2.0259032501700136e-07 6.69338129881808 -0.6887519022120736 LDDTVHVVIATPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDDTVHVVIATPGR 14 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 14069300.0 2535900.0 4705800.0 6827600.0 False True 3473490.7601207155 4497882.196000384 5215061.49883589 1.0 1.2949169888806809 1.5013891957653138 21.727954828927896 -6.974947473780552 0.07385634473441506 0.1844836862227771 2.616989057677252 0.9999999269794889 5.529784349714521e-05 0.07472771760799442 0.002135711622762254 0.027443071090081178 0.04265226721841738 1.0593818455212242e-07 6.974947473780552 2.432505371454475 LDDTVHVVIATPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDDTVHVVIATPGR 14 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 9245400.0 2987300.0 3729700.0 2528400.0 False True 2484072.309828826 3709607.3658125103 3057076.749999262 1.0 1.4933572388913807 1.2306714011114759 21.244275739465934 -10.164896624829675 4.66527221042077 0.9999540022516278 1.3620143200048551 0.7168991615190419 0.1072410442144593 5.131403743326057e-05 9.185263713522734e-06 0.10384886220932461 0.034611898187713715 6.840744582333123e-11 10.164896624829675 0.36206031775322733 LDEGWVPLEIMIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDEGWVPLEIMIK 13 0 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 0 22683900.0 0.0 16363000.0 6320900.0 False True 0.0 13442894.805297479 5071571.344451118 0.0 LDEGWVPLEIMIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDEGWVPLEIMIK 13 0 P05455;E7ERC4;E9PFL9 P05455 SSB Lupus La protein 0 9761700.0 0.0 6473200.0 3288500.0 False True 0.0 6112960.729599887 2690026.742859421 0.0 LDEIYVAGLVAHSDLDER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDEIYVAGLVAHSDLDER 18 0 O60506;O60506-2;O60506-3;O60506-4;F6UXX1 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 8708500.0 2889600.0 2807900.0 3011000.0 False True 2797871.2296870714 3929109.113005059 2222328.771936222 1.0 1.404320924892784 0.7942927281127155 21.415898134197487 -6.727985121977059 1.7303593638613184 1.2438626138916251 0.794773660003287 0.5499626148368864 0.16999607428880573 0.3400454540075122 1.9936557448949026 0.07788001518802255 0.1937124169175813 1.870746227131115e-07 6.727985121977059 -0.44908895388833814 LDELQDK(ub)SESLSDNATAFSNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDELQDKSESLSDNATAFSNR 21 1 O75379-2;O75379 O75379-2 VAMP4 Vesicle-associated membrane protein 4 1 6706100.0 2204100.0 2181500.0 2320500.0 True False 2889596.4445347646 1856028.7034204 2080396.9198077682 1.0 0.6423141566812203 0.719961060217431 21.46243659211189 -9.925972795583618 5.448154500067922 1.0000004488871286 0.6811376084481376 0.9574200187174206 0.03169921563265393 1.7283411342548274e-07 3.4082551652940086e-08 0.03069267654694479 0.01023087785215293 1.1858430276214378e-10 9.925972795583618 -0.31886284043899094 LDELYGTWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDELYGTWR 9 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 36537500.0 6667500.0 15875000.0 13995000.0 False True 8741157.068161838 13506511.880265348 12546931.649519378 1.0 1.5451629315140092 1.4353856762532526 23.059392831431246 -10.011961839096235 4.641388794815209 0.9999880098441613 1.4902743038872235 0.9637609285872489 0.04481637688586252 30924145.97764703 0.09355300585711704 4204.6318568830975 0.015341837839694117 9.728327015936818e-11 10.011961839096235 0.49028629404306223 LDELYGTWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDELYGTWR 9 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 25518900.0 8016200.0 2284700.0 15218000.0 False True 7761730.118846026 3196992.624553106 11231949.269785939 1.0 0.4118917529470115 1.4470935085096526 22.887946839735413 -6.7525784381756 1.6401298247696392 0.6552644888990067 1.4495845825420492 0.6600609754840743 0.24716607515372563 0.2955688792135423 1.5650616053378539 0.11900308421675163 0.2881491401365464 1.7677529140321303e-07 6.7525784381756 0.7943200936430426 LDELYGTWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDELYGTWR 9 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 26904700.0 6667500.0 9872200.0 10365000.0 False True 9132654.932412488 9436013.561000258 7917000.473875733 1.0 1.0332169156540807 0.8668892597461112 23.122602892954138 -6.854780606987049 1.2117705526240177 1.0178273484963012 0.8595998096222357 0.9469805325969963 0.016548584853224853 0.15227630028800232 0.4278836823785832 0.010671498554849957 0.02478262591925836 1.397073944175634e-07 6.854780606987049 -0.1582275388740655 LDELYGTWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDELYGTWR 9 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 17097400.0 8016200.0 5082300.0 3998900.0 False True 6665825.477872942 5054920.641142438 4835051.501175459 1.0 0.758333781453195 0.7253492485252282 22.66835211516969 -13.999999999989713 0.28062222962809985 2.9763229491772467 0.7154802084685092 0.9996065536242813 0.0024286459887705183 15.431991050368163 0.1678191726428383 17.509898789231315 0.013009378486289667 1.0000000000236865e-14 13.999999999989713 -2.2608427407087373 LDENSAFLQFNWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDENSAFLQFNWK 13 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54;A0A1B0GV13 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 10152200.0 3936400.0 3089200.0 3126600.0 False True 3811441.136676422 4322733.669965176 2307649.6640105615 1.0 1.134146774134521 0.605453313132584 21.861905164843453 -6.839431505164014 1.2849642481053667 1.0713702725416603 0.5882513628874584 0.923485267965505 0.06207064646096823 0.16946173676758977 0.5437569974680119 0.03788057108235759 0.08725996961968038 1.4473331015079544e-07 6.839431505164014 -0.4831189096542019 LDETPFGK(ub)MR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDETPFGKMR 10 1 Q9UJK0 Q9UJK0 TSR3 Ribosome biogenesis protein TSR3 homolog 1 10539700.0 3382300.0 5128800.0 2028600.0 True False 4434228.054239788 4363603.031905813 1818699.931705254 1.0 0.9840727582185479 0.41015029210468856 22.080251539858672 -6.912842849865996 0.8761475231969338 1.0162124096029226 0.33128591106676863 0.9919509194574121 0.02461652944157659 0.10256832270261766 0.12879088634327795 0.02044151582801631 0.05760402215500609 1.2222418502716893e-07 6.912842849865996 -0.684926498536154 down LDETPFGK(ub)MR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDETPFGKMR 10 1 Q9UJK0 Q9UJK0 TSR3 Ribosome biogenesis protein TSR3 homolog 1 18791800.0 6947800.0 8355900.0 3488100.0 True False 6727245.89203345 11692454.445442839 2574461.9692430203 1.0 1.7380744859184194 0.38269181929142115 22.681584561362012 -6.75881688974812 1.616811621922839 1.4293390430411268 0.3780071242449988 0.6861769389881729 0.3103863520198485 0.2849023504772246 1.4675550369065098 0.15148578265779397 0.3644870357142123 1.7425414209289935e-07 6.75881688974812 -1.0513319187961279 LDFLRPYTVPNK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDFLRPYTVPNKK 13 2 Q99436 Q99436 PSMB7 Proteasome subunit beta type-7 1 10160300.0 1980200.0 2451500.0 5728600.0 True False 2596061.3762840806 2085745.755872157 5135859.424611415 1.0 0.8034269817062749 1.9783274276676464 21.307893061372297 -6.863883911800815 1.1658859393199084 0.8920252278441861 2.039609626149046 0.9581928243253864 0.10506103763628306 0.14285815274149974 0.3667994375603447 0.07016149374603883 0.16457019417782756 1.3680944724222524e-07 6.863883911800815 1.14758439830486 LDFLRPYTVPNK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDFLRPYTVPNKK 13 2 Q99436 Q99436 PSMB7 Proteasome subunit beta type-7 1 37105700.0 2930700.0 10837000.0 23338000.0 True False 2837666.5326840756 15164270.61420843 17225077.6750075 1.0 5.3439227053451335 6.070155698920248 21.436273630918013 -9.61174533696292 0.5021281611628048 1.6333198182742377e-21 6.058766932844374 0.998631909751902 0.08280213165889837 0.91643477893453 0.21954713705216436 1.8116618015921542 0.14601022576437986 2.444863759759626e-10 9.61174533696292 6.058766932844374 LDFLRPYTVPNK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDFLRPYTVPNKK 13 2 Q99436 Q99436 PSMB7 Proteasome subunit beta type-7 1 100356400.0 5256700.0 41984700.0 53115000.0 True False 7974798.216247106 34492202.25704163 42616796.968868524 1.0 4.3251504704871975 5.3439342053878 22.927016584615153 -9.328234247076056 0.38552968019736233 1.2837227375248485e-22 5.523387393858238 0.9981131351426742 0.08057120294410307 0.7026569403209255 0.15247981271873645 1.2947396915690144 0.2667603296116436 4.696407283618009e-10 9.328234247076056 5.523387393858238 LDFLRPYTVPNK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDFLRPYTVPNKK 13 2 Q99436 Q99436 PSMB7 Proteasome subunit beta type-7 1 21972900.0 2930700.0 9361200.0 9681000.0 True False 2437006.9020236847 9310769.357547285 11705252.340113442 1.0 3.8205757028491156 4.80312646238032 21.21667890635229 -9.286679233418928 0.349683309723093 6.438114728562139e-25 5.061376683992185 0.9982767805470586 0.06691386140246888 0.6765993597050627 0.13502749692495786 1.166379664384344 0.2861311446064963 5.167979313428163e-10 9.286679233418928 5.061376683992185 LDFLRPYTVPNKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDFLRPYTVPNKK 13 2 Q99436 Q99436 PSMB7 Proteasome subunit beta type-7 0 10105300.0 1945000.0 2116900.0 6043400.0 False True 2549913.8354067905 1801066.7716115706 5418086.940386244 1.0 0.7063245614823861 2.124811774089571 21.282017066866512 -6.85271210876296 1.2219953239935275 0.8428525199564803 2.184536155185409 0.9441574621539418 0.14446426784741273 0.1544926206153188 0.4425914982878429 0.09244145877297964 0.21431074803047337 1.4037439297354783e-07 6.85271210876296 1.3416836352289288 up LDFLRPYTVPNKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDFLRPYTVPNKK 13 2 Q99436 Q99436 PSMB7 Proteasome subunit beta type-7 0 8108100.0 3047600.0 1385200.0 3675300.0 False True 2950855.606171898 1938317.583722572 2712628.673363404 1.0 0.6568662931755997 0.9192685225565671 21.492701896615134 -9.932744884060158 5.733469338442604 1.0000001611102844 0.7880674078658807 0.4651718652536726 0.10712526155940381 2.2057287318509778e-07 4.1110301326026167e-08 0.10372366809217208 0.034574529498035855 1.1674952329084668e-10 9.932744884060158 -0.21193275324440375 LDFLRPYTVPNKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDFLRPYTVPNKK 13 2 Q99436 Q99436 PSMB7 Proteasome subunit beta type-7 0 7874100.0 1945000.0 2825200.0 3103900.0 False True 2664119.061648637 2700373.3223129483 2370822.7468271037 1.0 1.0136083485104739 0.8899087060170529 21.345227128389404 -6.879623296734995 1.0819519438723253 1.0083918456421574 0.8812071438037001 0.9733779395985606 0.009036664702115196 0.1279618189896791 0.2743365472330691 0.006436282647857973 0.015549101536215672 1.3194006790625467e-07 6.879623296734995 -0.12718470183845731 LDFNLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDFNLIR 7 0 P31939-2;P31939;C9JLK0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 14833000.0 3419200.0 5002100.0 6411700.0 False True 4482604.311579903 4255806.178033085 5748278.7893693 1.0 0.9494048285812489 1.2823524874858534 22.09590572476541 -6.868166901069353 1.1438094740063867 0.97168149825765 1.3011790919780017 0.962815974429715 0.028248124236444832 0.13862134531188008 0.34011149249893885 0.019187682505294863 0.04528660154997585 1.3546687078160601e-07 6.868166901069353 0.3294975937203517 LDFNLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDFNLIR 7 0 P31939-2;P31939;C9JLK0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 10197900.0 3356000.0 1564300.0 5277600.0 False True 3249465.6169815212 2188933.147716731 3895238.2353937635 1.0 0.6736286533630303 1.1987319438117676 21.631771052043813 -6.738606458806547 1.6916384044463493 0.8054956185743093 1.1989554443248875 0.5986929775651284 0.1371332175736339 0.32036655995822894 1.799519373988707 0.06414252244144279 0.15765114476264172 1.825549196506755e-07 6.738606458806547 0.39345982575057825 LDFNLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDFNLIR 7 0 P31939-2;P31939;C9JLK0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 14525200.0 3419200.0 4979400.0 6126600.0 False True 4683370.640405673 4759393.643326178 4679623.261287707 1.0 1.016232540355576 0.9991998542490669 22.1591157862883 -6.6571107406716035 1.9834488488752395 1.010473776343974 0.9992716535588406 0.22323741077926673 0.006916317591012636 0.49135405035907526 3.712929054231267 0.0028204306828366493 0.007663371239247846 2.202364810842842e-07 6.6571107406716035 -0.011202122785133328 LDFNLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDFNLIR 7 0 P31939-2;P31939;C9JLK0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 7055500.0 3356000.0 1645400.0 2054100.0 False True 2790662.696008283 1636535.9036136712 2483602.8129146807 1.0 0.5864327157683888 0.8899688294350959 21.41217632747809 -10.05128624751568 6.701607417395047 1.0000001148315536 0.738200772601742 0.4979591830393858 0.12391809949847987 2.125627443434103e-07 3.014673922405766e-08 0.11998323754911831 0.0399943946376069 8.886152302681116e-11 10.05128624751568 -0.2617993422298116 LDFTVEHDSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDFTVEHDSLK 11 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 5098000.0 1250600.0 1537600.0 2309800.0 False True 1639548.7108276265 1308196.0735178585 2070804.0531661224 1.0 0.7979000958486285 1.2630329550384647 20.64486733401673 -6.788629177226205 1.502000680307185 0.886846027519894 1.26778204689169 0.796805707634955 0.08584120177040207 0.23739373102361142 1.0580744476457118 0.0449903162498191 0.10543067387129852 1.6269373248978454e-07 6.788629177226205 0.380936019371796 LDFVCSFLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDFVCSFLQK 10 0 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4;Q14980-5;F5H4J1;F5H6Y5;F5H763;F5H2F3;F5H3L6;F5H0Z7;F5GZW1;F5H073;F5H1L0;F8W6T3;F5H068;F5GWK2 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 0 7719300.0 1853800.0 3102300.0 2763200.0 False True 2430349.752224734 2639448.9326706836 2477290.5704860254 1.0 1.0860366621119206 1.0193144292167504 21.212732516690576 -10.13279035021341 3.9972173557419612 0.9999835094272851 1.0526755456654637 0.4538587053022691 0.027239237593434336 19022421.04018235 0.113218231236164 3150.713214005907 0.009324715537952695 7.365625773072689e-11 10.13279035021341 0.05269203623817864 LDFVCSFLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDFVCSFLQK 10 0 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4;Q14980-5;F5H4J1;F5H6Y5;F5H763;F5H2F3;F5H3L6;F5H0Z7;F5GZW1;F5H073;F5H1L0;F8W6T3;F5H068;F5GWK2 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 0 7802800.0 1853800.0 2319000.0 3630000.0 False True 2539199.9570613075 2216538.9120924985 2772668.7621967145 1.0 0.8729280677279806 1.091945813281128 21.275942578213467 -6.749426468812836 1.6521824841317292 0.925228518953656 1.0923565989630115 0.6464250557624535 0.05339471706797015 0.301039721353285 1.6166550000988644 0.025532730920362047 0.06201871812741415 1.7806293649233608e-07 6.749426468812836 0.16712808000935553 LDFYQHSWLPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDFYQHSWLPAR 12 0 Q9HB07;F8VR84;F8VQQ3 Q9HB07 C12orf10 UPF0160 protein MYG1, mitochondrial 0 11201000.0 3678400.0 4198900.0 3323700.0 False True 4822418.021676273 3572440.487184007 2979795.407181674 1.0 0.7407985933874365 0.617904834003979 22.201325282823777 -13.999999999998137 0.09918575150118147 2.2831923568877945 0.3528185032495591 0.9997977891064568 0.002264739524877704 12.086731410834407 0.09362539179049556 3.1812850421326546 0.23653568416535492 1.0000000000042906e-14 13.999999999998137 -1.9303738536382355 LDFYQHSWLPAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDFYQHSWLPAR 12 0 Q9HB07;F8VR84;F8VQQ3 Q9HB07 C12orf10 UPF0160 protein MYG1, mitochondrial 0 12030000.0 4346000.0 2303400.0 5380600.0 False True 4208038.608880131 3223159.6320723165 3971259.4454599977 1.0 0.7659529609045302 0.9437317036681976 22.004716510785276 -10.515645831955737 5.095533817088132 1.000494079618456 0.8548423322863613 0.470594865865806 0.07257786781409108 0.00040874629775391563 3.885325473705128e-05 0.07051006453211085 0.023424406112266857 3.050381568035148e-11 10.515645831955737 -0.14565174733209474 LDFYQHSWLPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDFYQHSWLPAR 12 0 Q9HB07;F8VR84;F8VQQ3 Q9HB07 C12orf10 UPF0160 protein MYG1, mitochondrial 0 13934300.0 3678400.0 4615000.0 5640900.0 False True 5038403.885022293 4411094.040235827 4308635.5979822185 1.0 0.8754943313196317 0.8551588352792711 22.26453534434667 -13.999999998630708 0.25499247723610646 1.8881405051726898 0.8473619701723042 0.9995522863828671 0.00135473312602308 14.201621926177642 0.15978808055543064 6.47986629485955 0.009131298993570573 1.0000000031529118e-14 13.999999998630708 -1.0407785350003858 LDFYQHSWLPAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDFYQHSWLPAR 12 0 Q9HB07;F8VR84;F8VQQ3 Q9HB07 C12orf10 UPF0160 protein MYG1, mitochondrial 0 8685700.0 4346000.0 2384900.0 1954800.0 False True 3613891.5604445827 2372052.0703344117 2363539.642026003 1.0 0.6563705719057604 0.6540150977123506 21.785121786219552 LDGFSVLMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDGFSVLMR 9 0 Q9NZL4;Q9NZL4-3 Q9NZL4 HSPBP1 Hsp70-binding protein 1 0 7606000.0 2630000.0 1973900.0 3002100.0 False True 3447955.4689562316 1679401.8142019357 2691471.490176645 1.0 0.48707178190741707 0.7805992607530428 21.717309711172625 -10.205641533805451 5.62031103543891 1.0000125641918074 0.6338355213302158 0.67478438266236 0.11983209144295441 1.8866263108471918e-05 2.6663497760738777e-06 0.11603090060059298 0.03867564120830516 6.228141431896615e-11 10.205641533805451 -0.3661770428615916 LDGFSVLMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDGFSVLMR 9 0 Q9NZL4;Q9NZL4-3 Q9NZL4 HSPBP1 Hsp70-binding protein 1 0 6529100.0 2630000.0 1631400.0 2267700.0 False True 3602382.0730775977 1559319.3536816326 1732115.9647475157 1.0 0.43285784851507164 0.4808251677945225 21.780519772695516 -10.121922245398922 7.987933665312847 1.000000052589776 0.45684150962885894 0.9941847798626979 0.01958257609397015 1.8367013609411515e-08 2.016118520871873e-09 0.018960749467151528 0.006320249257315506 7.552274289021249e-11 10.121922245398922 -0.5431585429609171 LDGLVETPTGYIESLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDGLVETPTGYIESLPR 17 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8VUX1;F8VXI6;P55209-3;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 17131420.0 929220.0 9358700.0 6843500.0 False True 1218216.4185792815 7962418.439926879 6135400.267487376 1.0 6.536127997037568 5.036379557782231 20.216339022991782 -9.983329398001393 6.7694650761106425 0.9999993724048659 5.78625377740992 0.9314119490643916 0.6122697364519111 5.804663997600335e-06 8.664876446671861e-07 0.5928276937786978 0.19760920772207724 1.0391317198187702e-10 9.983329398001393 4.786254405005054 LDGLVETPTGYIESLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDGLVETPTGYIESLPR 17 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8VUX1;F8VXI6;P55209-3;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 31546300.0 11337000.0 3576300.0 16633000.0 False True 10977113.140560046 5004335.240158125 12276318.320695834 1.0 0.45588809881782877 1.118355815732214 23.387995355585108 -6.688429193954917 1.8720774731555003 0.6583926393423789 1.1160258980463593 0.3632337095964181 0.23019145533923932 0.41994789565528523 2.852303822042161 0.09841468356488 0.2567797014904546 2.049136107613519e-07 6.688429193954917 0.4576332587039804 LDGLVETPTGYIESLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDGLVETPTGYIESLPR 17 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8VUX1;F8VXI6;P55209-3;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 23152220.0 929220.0 10477000.0 11746000.0 False True 1272777.745226299 10014091.497194102 8971836.716463523 1.0 7.8679027306637925 7.049020734463217 20.279549084514674 -9.119913510228354 10.294445287225273 0.9999999733152956 7.458461668938498 0.9880864640984511 0.33430717504832624 0.0 0.0 0.32369153036644205 0.107897176788814 7.587286608417969e-10 9.119913510228354 6.458461695623202 LDGSHPAFLYGYGGFNISITPNYSVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDGSHPAFLYGYGGFNISITPNYSVSR 27 0 P48147;A0A499FJL1 P48147 PREP Prolyl endopeptidase 0 39420000.0 11027000.0 12588000.0 15805000.0 False True 16728765.18168375 10341573.049507082 12681134.822422417 1.0 0.618191058167881 0.7580436861118078 23.995827622318927 -10.093250945023359 5.61986128921791 1.0000025014234377 0.688117373395796 0.8689557885518742 0.05709459627520619 1.7893955169155664e-06 2.8876752379508434e-07 0.05528204825913327 0.018427201710993903 8.067687266045687e-11 10.093250945023359 -0.3118851280276417 LDGTTK(ub)AEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDGTTKAEDR 10 1 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8Y4C5;A0A2R8YG32;A0A2R8Y7F3;A0A2R8Y6N0;A0A2R8YF80;A0A2R8YF58;A0A2R8Y526;A0A2R8Y7Y7;A0A2R8Y6V2;A0A2R8YDA1;A0A2R8Y523;A0A2R8YGP5 P51532 SMARCA4 Transcription activator BRG1 1 6394530.0 443310.0 2974210.0 2977010.0 True False 581183.7030201472 2530469.461379774 2668977.562696372 1.0 4.353992460955247 4.59231315129263 19.148634723344152 -10.075837309587097 0.5964645760730721 9.092524389547734e-23 4.5661066336133045 0.9995970778490985 0.032922565080846594 1.3524669152618476 0.2842104977438571 2.474976711710813 0.041488168431633596 8.397745142908594e-11 10.075837309587097 4.5661066336133045 LDGTTK(ub)AEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDGTTKAEDR 10 1 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8Y4C5;A0A2R8YG32;A0A2R8Y7F3;A0A2R8Y6N0;A0A2R8YF80;A0A2R8YF58;A0A2R8Y526;A0A2R8Y7Y7;A0A2R8Y6V2;A0A2R8YDA1;A0A2R8Y523;A0A2R8YGP5 P51532 SMARCA4 Transcription activator BRG1 1 7105000.0 1424600.0 2480940.0 3199460.0 True False 1379376.8527866153 3471592.279931188 2361425.4442574116 1.0 2.516783048024825 1.7119508997754045 20.39558523166632 -10.109934975012253 5.065037737535424 0.9999654208189713 2.114366973902807 0.7187961921698471 0.32857134864253995 114469514.69243287 3.2716885688983277 46163.87713649317 0.11247871212446081 7.763633493700061e-11 10.109934975012253 1.1144015530838356 LDGTTK(ub)AEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDGTTKAEDR 10 1 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8Y4C5;A0A2R8YG32;A0A2R8Y7F3;A0A2R8Y6N0;A0A2R8YF80;A0A2R8YF58;A0A2R8Y526;A0A2R8Y7Y7;A0A2R8Y6V2;A0A2R8YDA1;A0A2R8Y523;A0A2R8YGP5 P51532 SMARCA4 Transcription activator BRG1 1 4798440.0 443310.0 416110.0 3939020.0 True False 607213.6870022928 397724.88430824096 3008704.6026633866 1.0 0.6549998671336589 4.954935415762501 19.211844784867044 -6.887478429975288 1.0372229528808115 0.7547991127131342 5.306950625370106 0.9792331842692877 0.28112139056240865 0.12121127076840227 0.23400935258507424 0.2071715352970196 0.5119906239691376 1.295751051749699e-07 6.887478429975288 4.552151512656972 up LDGTTK(ub)AEDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDGTTKAEDR 10 1 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8Y4C5;A0A2R8YG32;A0A2R8Y7F3;A0A2R8Y6N0;A0A2R8YF80;A0A2R8YF58;A0A2R8Y526;A0A2R8Y7Y7;A0A2R8Y6V2;A0A2R8YDA1;A0A2R8Y523;A0A2R8YGP5 P51532 SMARCA4 Transcription activator BRG1 1 2716350.0 1424600.0 893680.0 398070.0 True False 1184618.0204807522 888865.5684584078 481304.5965322759 1.0 0.7503393947170248 0.4062951839420344 20.175990507100597 -6.966628063607851 0.3289143108710106 1.0424497079869912 0.10294034733460652 0.9999428782598395 0.0018395650964764109 0.07741274641472057 0.01293491721562261 0.00503974993285298 0.03003470398112602 1.079871144382305e-07 6.966628063607851 -0.9395093606523847 down LDHIIK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDHIIKER 8 1 B5MCF9;O00541-2;O00541 B5MCF9 PES1 Pescadillo homolog 1 5040700.0 1400400.0 1620900.0 2019400.0 True False 1835937.9614928903 1379068.0382187131 1810451.8594526234 1.0 0.751151763917625 0.9861182117398222 20.8080858785341 -10.556088367139175 8.28014630763335 1.0000277221202092 0.8686349878733919 0.29416435178288647 0.09592465063977848 4.910075365002399e-05 2.6324178404675367e-06 0.09289821814312214 0.030959547868218907 2.77914772909585e-11 10.556088367139175 -0.1313927342468173 LDHIIK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDHIIKER 8 1 B5MCF9;O00541-2;O00541 B5MCF9 PES1 Pescadillo homolog 1 13368000.0 1004200.0 2939500.0 9424300.0 True False 1523444.8168537968 2414923.2585816723 7561582.974182577 1.0 1.585172782017105 4.963476780077064 20.538905812116386 -6.936655694663032 0.6899716706128254 0.9590067452014027 5.79135368063271 0.9976922761461116 0.08391828837844015 0.08932592354963483 0.06180836390921978 0.0797498439117371 0.2953013325457501 1.157029162533343e-07 6.936655694663032 4.832346935431308 up LDHIIK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDHIIKER 8 1 B5MCF9;O00541-2;O00541 B5MCF9 PES1 Pescadillo homolog 1 19499600.0 1004200.0 2506400.0 15989000.0 True False 1299956.695741341 2366916.636697326 13079166.06099417 1.0 1.8207657566220061 10.06123211937869 20.310032134208836 -6.926131427104552 0.7778969351222136 0.8550971435486023 11.59750977291792 0.9957216526142645 0.26764035125594754 0.09469689341548355 0.0878915573126146 0.23843866004976555 0.7620947683733607 1.1854099626392004e-07 6.926131427104552 10.742412629369317 up LDHK(ub)FDLMYAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LDHKFDLMYAK 11 1 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 570247300.0 160317200.0 250370700.0 159559400.0 True False 210177401.7139733 213016367.49734458 143049723.88984087 1.0 1.0135074739730334 0.6806141988781206 27.64703231808582 -6.89744345484963 0.9773057040481885 1.0148279811869478 0.6474323187987134 0.9852503816502161 0.018683865908610462 0.11331105560644025 0.18823037692217784 0.014404761978141348 0.037019715550006785 1.266358136632856e-07 6.89744345484963 -0.3673956623882344 LDHK(ub)FDLMYAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LDHKFDLMYAK 11 1 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 489030200.0 171062900.0 162911300.0 155056000.0 True False 165632601.87459755 227962631.66120654 114442182.01970887 1.0 1.3763149831685904 0.6909399521861912 27.303411429119333 -6.757624145348766 1.6212975909027534 1.219229667559646 0.6887165248589415 0.6812258024533744 0.15823046514415817 0.286934265739809 1.4859495592340455 0.07702181502631524 0.1855409417290323 1.7473337065437112e-07 6.757624145348766 -0.5305131427007044 LDHK(ub)FDLMYAK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LDHKFDLMYAK 11 1 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 988832000.0 305053700.0 173561000.0 510217300.0 True False 462788765.31275874 142587683.5117175 409372627.01881343 1.0 0.3081053262288138 0.8845777116956459 28.785778601019878 -10.351252495833947 8.197073881725794 1.000001941703259 0.5963415189623756 0.3953126799126754 0.23534386586645928 8.351438131688956e-06 6.60715753704527e-07 0.22787181813310617 0.07595690609440574 4.4539722221574024e-11 10.351252495833947 -0.40366042274088343 LDHK(ub)FDLMYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LDHKFDLMYAK 11 1 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 429745600.0 160317200.0 159074500.0 110353900.0 True False 219590801.249428 152046062.60097378 84290581.62991184 1.0 0.6924063382248342 0.3838529717561719 27.71024237960871 -7.110360451402871 0.24643341486327594 1.1099156548654796 1.7945514385916315e-13 0.9999817160449057 0.0010755676338680296 0.0776076531552537 0.009738980975183218 0.008723944038667775 0.031759722505063565 7.756031220734029e-08 7.110360451402871 -1.1099156548653002 down LDHK(ub)FDLMYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LDHKFDLMYAK 11 1 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 461296200.0 171062900.0 194945300.0 95288000.0 True False 142246380.7213934 193895090.9752876 115212280.23806734 1.0 1.3630933173270283 0.8099487639247878 27.08381670455361 -6.729619169700455 1.724449690332205 1.218601164267168 0.810291434508576 0.5575393675249867 0.1526409043024971 0.33697019577173754 1.9629173195856655 0.07014754270864264 0.17415270624019574 1.8637207061474312e-07 6.729619169700455 -0.4083097297585919 LDHK(ub)FDLMYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LDHKFDLMYAK 11 1 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 707872500.0 305053700.0 135958600.0 266860200.0 True False 394898028.1574085 128392384.39278531 218294381.8168811 1.0 0.3251279450339707 0.5527867101171439 28.556904923112327 -10.140101231019328 5.435809295118273 1.0000118781874148 0.43895732757551725 0.8900821288163674 0.09294130165485266 1.3379311307810922e-05 2.11643696390731e-06 0.08999193185020149 0.02999667612359649 7.242671187762605e-11 10.140101231019328 -0.5610545506118976 LDHK(ub)FDLMYAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 2 LDHKFDLMYAKR 12 2 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 2 35590820.0 11908100.0 17563400.0 6119320.0 True False 15611634.418204434 14943009.181597004 5486151.467062301 1.0 0.9571713493477814 0.3514142927062783 23.896118248523095 -6.921160000299381 0.816084340955067 1.0128152456231578 0.2510781153625339 0.9944969261755879 0.021970542362527355 0.0974942232876718 0.10211519642212077 0.01904701379448658 0.057702565123951104 1.1990574718416688e-07 6.921160000299381 -0.761737130260624 down LDHK(ub)FDLMYAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 2 LDHKFDLMYAKR 12 2 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 2 27875800.0 11607100.0 10450600.0 5818100.0 True False 11238638.963905325 14623579.07915904 4294165.070741327 1.0 1.301187726211776 0.3820894224409842 23.42196399524046 -6.818442351777219 1.3787466031593318 1.162595015148556 0.36270876658847895 0.8807359867977873 0.1321206575712097 0.19551019216284035 0.7307202671829955 0.07531403180889772 0.1736506228497057 1.518999560558219e-07 6.818442351777219 -0.7998862485600771 down LDHK(ub)FDLMYAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LDHKFDLMYAKR 12 2 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 2 27695300.0 11908100.0 10258600.0 5528600.0 True False 16310846.374302397 9805341.131346317 4222858.545091112 1.0 0.6011546492642191 0.25889879949725914 23.959328310045986 -7.723582757377157 0.28890024801260494 1.112203127578425 8.585455820629742e-13 0.9995572587745596 0.006372330927418394 0.12429859860616099 0.04108541766329174 0.037586148198937894 0.07942469041295029 1.8898060831691947e-08 7.723582757377157 -1.1122031275775663 down LDHK(ub)FDLMYAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LDHKFDLMYAKR 12 2 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 2 37085400.0 11607100.0 20514700.0 4963600.0 True False 9651817.93171567 20404183.239250854 6001465.810906625 1.0 2.114024879417083 0.6217964173553188 23.202369270674737 -6.706874842786961 1.8064692766962924 1.687068765058818 0.6256397962042501 0.4501514894129176 0.4696822019249577 0.3814139703236337 2.4243203563377116 0.20706560147964126 0.5280225921078987 1.9639261696156272e-07 6.706874842786961 -1.061428968854568 LDHKFDLMYAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LDHKFDLMYAK 11 1 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 103700600.0 33720200.0 31638200.0 38342200.0 False True 44207508.74688135 26917903.884737704 34374916.948353104 1.0 0.6088989098856796 0.7775809567821012 25.397788099707117 -10.203331388399274 5.4158950795381156 1.0000148636410884 0.6932399333338488 0.8151432612728449 0.06886415727755538 1.2359816627047336e-05 1.818028336539541e-06 0.06668066244178852 0.0222258111905272 6.261359093454105e-11 10.203331388399274 -0.30677493030723957 LDHKFDLMYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDHKFDLMYAK 11 1 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 215880000.0 28798000.0 136580000.0 50502000.0 False True 43688671.41580926 112206231.89558934 40520257.56418705 1.0 2.5683141249057573 0.9274774501273646 25.380755897918423 -6.6564423957307275 1.9858370520145816 2.0124536034649845 0.934391452750504 0.22052303419864672 0.6683253775893845 0.4928926917522463 3.732814666031909 0.27228175617015016 0.7404674802713583 2.2057566857599134e-07 6.6564423957307275 -1.0780621507144805 LDHKFDLMYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDHKFDLMYAK 11 1 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 12225500.0 5436200.0 4109800.0 2679500.0 False True 7446110.047781149 3928215.446708819 2046657.2860347365 1.0 0.52755269818761 0.2748626159029997 22.82805550759457 -9.282395257059244 0.18998702503247378 1.4710554242454896 9.70742685964451e-19 0.9995963131548178 0.00603830233986814 0.7104146655377103 0.0695626303394726 0.34444086297305565 0.148709218290318 5.21920965716072e-10 9.282395257059244 -1.4710554242454896 LDHKFDLMYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LDHKFDLMYAK 11 1 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 19308810.0 7207500.0 6801900.0 5299410.0 False True 5993355.596388468 6765256.814628565 6407492.129296619 1.0 1.128792828295594 1.0690992760645983 22.514932543420535 -10.435570442627604 6.1449855835364025 0.9999663498520528 1.098946052180096 0.7855628099647127 0.024369790650019266 1.1238534965717519e-05 1.0322657667801057e-06 0.023603967732473603 0.007865316111507143 3.668001945715647e-11 10.435570442627604 0.0989797023280432 LDHKFDLMYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDHKFDLMYAK 11 1 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 35238400.0 11651000.0 13650000.0 9937400.0 False True 15082449.175545078 12890365.500685643 8128895.166334567 1.0 0.8546599660740967 0.538963869310754 23.84636738502697 -6.958398562063316 0.45744466189174143 1.0094405728614706 0.37151133146387605 0.9997061148004278 0.0032992254868900455 0.08027821343123571 0.023283078922461883 0.004269205727915684 0.026087278700899996 1.1005288652342987e-07 6.958398562063316 -0.6379292413975945 LDHKFDLMYAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 2 LDHKFDLMYAKR 12 2 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 32712100.0 14675400.0 6760960.0 11275740.0 True False 19239591.516775757 5752251.122015668 10109034.58933559 1.0 0.29897989866365166 0.5254287535429807 24.197574833227087 -10.108493527820876 5.1435283142115695 1.0000152664339679 0.41220432610260443 0.8998359052355325 0.09244735788541368 1.618480435747509e-05 2.8052301116881515e-06 0.08951409124975632 0.029837256457097734 7.789444228758518e-11 10.108493527820876 -0.5878109403313634 LDHKFDLMYAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDHKFDLMYAKR 12 2 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 104932700.0 26534600.0 5581100.0 72817000.0 True False 40254928.1391045 4585109.099666667 58424688.033175126 1.0 0.11390180809222694 1.4513673414416093 25.26266207766554 -6.728058697411711 1.7301310800941037 0.46559836367152285 1.4503172284425068 0.5502839808465516 0.37255627800457575 0.33990813736537473 1.9923672776103494 0.17070004363257152 0.4245434133388164 1.8704293239374388e-07 6.728058697411711 0.9847188647709839 LDHKFDLMYAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDHKFDLMYAKR 12 2 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 85227600.0 26534600.0 11213000.0 47480000.0 True False 34349562.77516248 10588986.692980818 38839127.185940534 1.0 0.30827136759474316 1.1307022287347532 25.033788399757988 -6.6836496517635355 1.8886902435946364 0.5637840845234456 1.127684734262139 0.34100474888254795 0.29293889633582587 0.43046752297392693 2.9718089694898855 0.12430669350930498 0.326353183693989 2.0718120193150817e-07 6.6836496517635355 0.5639006497386934 LDHKFDLMYAKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDHKFDLMYAKR 12 2 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;Q9BQE3;F5H5D3 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 11371300.0 6702800.0 1056300.0 3612200.0 False True 8787435.710007533 898704.1574251519 3238444.1946690856 1.0 0.10227149160268297 0.36853119630576614 23.06701079860834 -10.399016345663236 5.37335172269863 1.0004509589140254 0.2354013439542131 0.916631871954681 0.10870006926448686 0.0005875654208424265 6.571634249961395e-05 0.10530714639652025 0.03508279649940671 3.9900988443258297e-11 10.399016345663236 -0.7650496149598123 LDHYAIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDHYAIIK 8 0 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9 P62750 RPL23A 60S ribosomal protein L23a 0 6216970.0 963370.0 2523800.0 2729800.0 False True 1262987.399288352 2147258.87769535 2447346.482090606 1.0 1.7001427559018032 1.9377441797674289 20.26840881488282 -10.814807550900786 0.21694476216895045 2.4134423078912073e-13 2.0997378277788554 0.9993049228569354 0.010494403475184879 2.7114345220471816 0.11545629362222466 1.524068402249513 0.13165938757720272 1.5317660834705906e-11 10.814807550900786 2.0997378277786143 LDHYAIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDHYAIIK 8 0 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9 P62750 RPL23A 60S ribosomal protein L23a 0 6607740.0 1940600.0 927840.0 3739300.0 False True 1878996.7152307348 1298331.3506216803 2759865.153404555 1.0 0.6909705270358865 1.4687972208964997 20.841531114036123 -6.798904044306253 1.4603638348667778 0.8292543887630777 1.4792477105990485 0.8289331742329642 0.13225822110809884 0.22233315440628623 0.9362190001242228 0.07125063917106542 0.16581601103673627 1.5888977706630502e-07 6.798904044306253 0.6499933218359708 LDHYAIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDHYAIIK 8 0 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9 P62750 RPL23A 60S ribosomal protein L23a 0 6438970.0 963370.0 2507100.0 2968500.0 False True 1319553.9230953485 2396328.0321289836 2267401.4381765663 1.0 1.8160137226584785 1.718309042542044 20.331618876405713 -10.186513018462588 4.516442420373315 0.9998375126926743 1.7671613826125367 0.9879810328388483 0.03988776866960171 4600511.464332203 10376143.792572612 4615.842025525062 0.013654643463576324 6.508591003188665e-11 10.186513018462588 0.7673238699198625 LDIDSPPITAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDIDSPPITAR 11 0 P14618;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 107607800.0 1785800.0 52115000.0 53707000.0 False True 2341201.0937117985 44339645.14267891 48149914.833921984 1.0 18.938845219989936 20.56633023248076 21.158817427072197 -9.377387269757907 0.7742969043455878 3.452700832883124e-17 20.25259837152623 0.9990763900971898 0.26941542424071674 0.7626034297600813 0.38518780917948825 2.994063098993772 0.23789147896312068 4.1938484268986806e-10 9.377387269757907 20.25259837152623 LDIDSPPITAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDIDSPPITAR 11 0 P14618;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 92287000.0 25274000.0 11533000.0 55480000.0 False True 24471690.70428814 16138187.043800466 40948123.63567639 1.0 0.6594635098494684 1.6732854354235978 24.544610442230034 -6.816134089868848 1.3886510963919347 0.8157034146571073 1.6936102911210282 0.8752166886045155 0.14880751284874955 0.19856317629820058 0.7534153545987075 0.08423266909925027 0.19435865264111923 1.5270944899289028e-07 6.816134089868848 0.877906876463921 LDIDSPPITAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDIDSPPITAR 11 0 P14618;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13;H3BN34;H3BQZ3 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 104499800.0 1785800.0 63474000.0 39240000.0 False True 2446058.519430405 60669508.79955124 29972320.173167758 1.0 24.80296702536736 12.25331280305885 21.22202748859509 -9.209364421580359 9.072849436567633 1.0000002273256732 18.52813993491993 0.7223023757872937 5.123374882246307 0.0 0.0 4.960687507594852 1.6535621329316785 6.174980328616336e-10 9.209364421580359 17.528139707594256 LDIK(ub)LDSEDKDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDIKLDSEDKDK 12 2 P13639 P13639 EEF2 Elongation factor 2 1 12533400.0 5402900.0 3670900.0 3459600.0 True False 7083254.221758026 3123216.0290561253 3101633.7788265306 1.0 0.4409295404734125 0.4378826005283094 22.755980891632756 LDIK(ub)LDSEDKDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDIKLDSEDKDK 12 2 P13639 P13639 EEF2 Elongation factor 2 1 23556200.0 5311900.0 6568300.0 11676000.0 True False 5143276.642087057 9191056.443232007 8617705.327508243 1.0 1.7870040992977636 1.6755282531354019 22.294256323526582 -10.078946023168927 4.347012069633137 0.999929102887538 1.7312661762911474 0.9828695900234985 0.04550982390707378 5203593.001157915 2413003.1725922455 3404.366919979575 0.015579223146364484 8.337848061641621e-11 10.078946023168927 0.7313370734036094 LDIK(ub)LDSEDKDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDIKLDSEDKDK 12 2 P13639 P13639 EEF2 Elongation factor 2 1 65910000.0 13045000.0 27446000.0 25419000.0 True False 19790218.717245325 22548046.863423247 20394923.508456532 1.0 1.1393530908162592 1.0305557406843746 24.238284221040697 -10.452819143151036 4.558715455609084 0.9997278902343342 1.084954415750384 0.44841860170494685 0.04441633219856922 0.0001232299596638978 1.4791301018957583e-05 0.04314334448056618 0.014335309575357332 3.525176423219622e-11 10.452819143151036 0.08522652551604992 LDIK(ub)LDSEDKDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDIKLDSEDKDK 12 2 P13639 P13639 EEF2 Elongation factor 2 1 14786900.0 5402900.0 3819200.0 5564800.0 True False 7400498.137882485 3650455.1155945156 4250508.850653517 1.0 0.49327154031809883 0.5743544247238634 22.819190953155648 -10.742588135166281 6.9547981487614745 1.0075563587017882 0.5338129825212873 0.9778151714183468 0.033101948944532424 0.003884363777150922 0.00014376838213877647 0.03210010994331998 0.010683608082431854 1.808888779428945e-11 10.742588135166281 -0.4737433761805009 LDIK(ub)LDSEDKDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDIKLDSEDKDK 12 2 P13639 P13639 EEF2 Elongation factor 2 1 20686900.0 5311900.0 9243100.0 6131900.0 True False 4417080.2070698505 9193305.585688297 7414051.939297762 1.0 2.081308274858527 1.678496108680808 22.07466159896086 -10.154984788255984 4.695243470377873 0.9999223077488925 1.8799021916933643 0.864169699990792 0.16444737854458638 115092764.04646134 21.6297039494476 117976.58747962867 0.05629471166808706 6.998665093317832e-11 10.154984788255984 0.8799798839444718 LDIK(ub)LDSEDKDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDIKLDSEDKDK 12 2 P13639 P13639 EEF2 Elongation factor 2 1 67891000.0 13045000.0 25752000.0 29094000.0 True False 16887009.65539312 24318878.562172674 23799190.529649425 1.0 1.4400938388997768 1.40931941269121 24.009410543133146 -10.203918639294523 4.924686843216711 0.9999489920778221 1.4247066257961958 0.9960775594775463 0.012563606892082803 7.036946588812775e-06 1.1375276138838721e-06 0.012166116908195815 0.004054886688097757 6.252898235664787e-11 10.203918639294523 0.4247576337183737 LDILK(ub)IHAGPITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDILKIHAGPITK 13 1 A0A087X2I1;P62333 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 7472900.0 2454800.0 2895700.0 2122400.0 True False 3218266.572317019 2463672.8473501937 1902794.4074983886 1.0 0.7655278989448195 0.5912482278086911 21.61785240024311 -6.9883723144679 0.11219254188115126 1.3547550265788768 6.9828460200237804e-15 0.9999996011762452 0.00010560645744545068 0.07349832883283965 0.003294284041659263 0.01340999081695384 0.02600701557908106 1.0271353720664351e-07 6.9883723144679 -1.35475502657887 LDILK(ub)IHAGPITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDILKIHAGPITK 13 1 A0A087X2I1;P62333 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 12383900.0 3447500.0 4178000.0 4758400.0 True False 3338060.9995660917 5846297.187982177 3512032.2910598908 1.0 1.7514051387143994 1.052117469248289 21.670578888005334 -10.165201507502342 4.649870958936917 0.9999472452092517 1.4017613039854442 0.30560956139468953 0.28548299561602797 200003697.99808726 11.969585241866316 112968.56013604408 0.09772842279980078 6.835943939736511e-11 10.165201507502342 0.4018140587761925 LDILK(ub)IHAGPITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDILKIHAGPITK 13 1 A0A087X2I1;P62333 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 7551600.0 2454800.0 3284100.0 1812700.0 True False 3362405.8984756237 3138997.6029335824 1384577.593728368 1.0 0.9335570117684705 0.41178181205192343 21.681062461766 -6.930442812404787 0.743149304076563 1.0078056878344508 0.3034464021519639 0.996624540258534 0.015281721887910724 0.09240858648540518 0.0765587978196839 0.013959220363843347 0.04709723797928138 1.1737002243450138e-07 6.930442812404787 -0.704359285682487 down LDILK(ub)IHAGPITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDILKIHAGPITK 13 1 A0A087X2I1;P62333 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 12039600.0 3447500.0 6673100.0 1919000.0 True False 2866749.000145579 6637150.685793355 2320254.027546501 1.0 2.315218627600919 0.8093676940076281 21.45098416343961 -6.675909130134484 1.9162598441743421 1.8352075325416852 0.8152562586542891 0.3054626547622712 0.5579301590988356 0.4477443112129119 3.1750628960891434 0.23392486388999018 0.6202502886107605 2.1090693961652488e-07 6.675909130134484 -1.0199512738873961 LDILK(ub)IHAGPITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDILKIHAGPITK 13 1 A0A087X2I1;P62333 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 21608400.0 4943000.0 4443400.0 12222000.0 True False 6398810.9410968395 4196120.883937478 9997721.408310123 1.0 0.6557657231263982 1.5624342554175203 22.609372410568106 -6.803804877992832 1.4401852149004153 0.8109787909599097 1.5761804131592 0.8431023855943479 0.14802441937457744 0.2153637239371791 0.8814196818443489 0.08084112128239507 0.1876002368925736 1.571068503343517e-07 6.803804877992832 0.7652016221992904 LDIMIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDIMIR 6 0 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 4875700.0 1440700.0 1386300.0 2048700.0 False True 1888771.6517586452 1179469.443755077 1836720.1765180663 1.0 0.6244637580497711 0.972441626179579 20.84901686300986 -10.467461707710385 8.696339558155785 1.000004712411208 0.7984526930746236 0.3090536218168779 0.14206136978325365 1.2979743331045919e-05 7.950270447489662e-07 0.1375535445783008 0.04585010994249623 3.4083037491754934e-11 10.467461707710385 -0.2015520193365843 LDIMIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDIMIR 6 0 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 6714600.0 1440700.0 1937400.0 3336500.0 False True 1973365.7234535697 1851799.2618749526 2548487.4173744707 1.0 0.9383963853563522 1.2914420206480457 20.912226924532753 -6.86187106073822 1.176135937388092 0.9663919012624198 1.3091683062224224 0.9558810304543902 0.03234170098664679 0.1448929412579493 0.3797804328615697 0.021429244379828464 0.05013606405210197 1.3744499798753865e-07 6.86187106073822 0.3427764049600026 LDK(ub)QHTFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDKQHTFR 8 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 13760500.0 4982300.0 6270000.0 2508200.0 True False 6531843.548661828 5334540.440268583 2248675.524353308 1.0 0.8166975219976701 0.3442635310538006 22.639058805068725 -6.954805391782917 0.5033330382464689 1.0091941215926166 0.1312746004261352 0.9995264220634504 0.006011520841314284 0.08161162030094674 0.028406423967182865 0.007006547332566875 0.038976626825046955 1.1096719500681029e-07 6.954805391782917 -0.8779195211664814 down LDK(ub)QHTFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDKQHTFR 8 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 16386300.0 7515100.0 6006800.0 2864400.0 True False 7276537.264057758 8405346.565048177 2114127.7098419503 1.0 1.1551300103369413 0.29054035362185554 22.79482063781879 -6.860499303506475 1.1832881239594581 1.0842732584710437 0.24828690824304245 0.9542405098715716 0.0805118316327422 0.1462831911724738 0.3889280817522688 0.05305993534981772 0.12392165353963672 1.3787981641947968e-07 6.860499303506475 -0.8359863502280013 down LDK(ub)QHTFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDKQHTFR 8 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 24451100.0 7091100.0 6312000.0 11048000.0 True False 10757717.128850782 5185574.284118903 8864357.957489574 1.0 0.4820329649876994 0.8239999110700292 23.358868623489624 -9.908406551457405 5.441906550765282 1.0000003980699201 0.6530164380272087 0.5785463158882995 0.1396074211390918 6.742041765710184e-07 1.3547066299181213e-07 0.13517445936132544 0.04505810142237765 1.2347909805403462e-10 9.908406551457405 -0.3469839600427115 LDK(ub)QHTFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDKQHTFR 8 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 13534900.0 4982300.0 5266800.0 3285800.0 True False 6824390.951594862 5034095.361021462 2509761.713175196 1.0 0.7376622172920783 0.36776347237091744 22.702268866591616 -6.96626498923564 0.33563385107224014 1.0422052889724096 0.05100847112236566 0.999936896037711 0.0020602291265920183 0.07753427624906518 0.013360551193193574 0.005294367183740819 0.03212105319836661 1.0807743045385302e-07 6.96626498923564 -0.991196817850044 down LDK(ub)QHTFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDKQHTFR 8 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 19240000.0 7091100.0 3284900.0 8864000.0 True False 9179568.736478211 3102092.4273408307 7250842.952320483 1.0 0.33793444075576085 0.7898892813457276 23.129994945582073 -10.28270075361157 5.730412894825056 1.000033818428579 0.5639118610510124 0.5538419992570068 0.18450979103773643 7.972507556544877e-05 9.979306717341721e-06 0.1786646577642204 0.05955027899177814 5.2155395900509717e-11 10.28270075361157 -0.43612195737756665 LDK(ub)SLKHELESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDKSLKHELESK 12 2 E9PEZ5;A0A1B0GUL6;Q9UPP5-2;Q9UPP5 E9PEZ5 KIAA1107 Uncharacterized protein KIAA1107 1 39891000.0 12101000.0 17313000.0 10477000.0 True False 18358101.70160108 14223359.882913606 8406216.35776777 1.0 0.7747729102989517 0.45790226540877216 24.12991355045369 -6.96630025780977 0.3349870456604146 1.0364275582998876 0.18579655231592948 0.999937492954857 0.0017580164871885816 0.07752245113199804 0.013319119114997299 0.004545052974709173 0.027529869778492855 1.0806865396173224e-07 6.96630025780977 -0.8506310059839581 down LDK(ub)SLKHELESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDKSLKHELESK 12 2 E9PEZ5;A0A1B0GUL6;Q9UPP5-2;Q9UPP5 E9PEZ5 KIAA1107 Uncharacterized protein KIAA1107 1 26138100.0 12101000.0 7002200.0 7034900.0 True False 15664983.046371214 6612521.414571516 5754620.384169609 1.0 0.4221211982800903 0.3673556726576008 23.90103987254614 -13.999999999999996 0.3332848817124231 7.4165947305056035 0.3580257896639375 0.9997216191226508 0.004775133236019207 19.10457202539684 0.1847899340632823 86.07385133998024 0.017337434151213797 1.0000000000000082e-14 13.999999999999996 -7.058568940841666 LDKESYPVFYLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDKESYPVFYLFR 13 1 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 7339200.0 2243400.0 2678600.0 2417200.0 False True 2941119.1251165066 2278963.3211010206 2167091.331419668 1.0 0.7748626370279184 0.736825418907105 21.487933788684924 -13.999999999999998 0.2501807862509471 2.5671531503114666 0.7215575329445487 0.999543026641498 0.002482690357412505 14.005186793089772 0.1582743422466176 11.031266630750528 0.017536351424772573 1.0000000000000041e-14 13.999999999999998 -1.845595617366918 LDKESYPVFYLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDKESYPVFYLFR 13 1 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 7211000.0 3552000.0 1080000.0 2579000.0 False True 3439243.7042664983 1511249.6321255963 1903482.5316584278 1.0 0.4394133600508856 0.5534596252359474 21.713659917954097 -10.35827928840175 5.845608368723922 1.0000892907123395 0.4964364926436595 0.9629557147007948 0.04655919279559322 5.4190000739809264e-05 5.949016778231323e-06 0.0450886719926012 0.01502691485918225 4.3824877578469763e-11 10.35827928840175 -0.50365279806868 LDKESYPVFYLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDKESYPVFYLFR 13 1 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 10828600.0 2243400.0 4151800.0 4433400.0 False True 3072845.605605432 3968359.747833399 3386322.2287390935 1.0 1.2914282906353596 1.1020150906904738 21.551143850207815 -10.26119073150835 3.7885983695363645 0.9996904202004371 1.1967216907272533 0.5898633001960227 0.07732761530479834 10042865.432671553 9066899.810420945 22555.025820933173 0.026471300098567956 5.480362279621141e-11 10.26119073150835 0.19703127052681624 LDLAGPLLAFLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDLAGPLLAFLFR 13 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 1167430000.0 451510000.0 458890000.0 257030000.0 False True 684973679.8024868 376997494.1760655 206227907.83974874 1.0 0.5503824530670628 0.30107420755088704 29.35147331250351 -9.193018387179531 0.1807711918843321 1.4707415447958947 9.764615850196756e-20 0.9996699878513376 0.005253944769239743 0.6305054798517717 0.06380093220184664 0.3190997849958449 0.15380921099261088 6.411824295996178e-10 9.193018387179531 -1.4707415447958947 LDLAGPLLAFLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDLAGPLLAFLFR 13 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 635716000.0 451510000.0 44776000.0 139430000.0 False True 584488595.5926831 42284176.23873272 114055170.67261352 1.0 0.07234388584751722 0.1951366913446092 29.12259963459596 -10.527856204274308 6.140432100635984 1.0010926503193507 0.1337402885963827 0.9851538131227576 0.05012995292544955 0.0007506241209404137 5.7715993960425785e-05 0.04858768083778375 0.01617937273553565 2.965813213346931e-11 10.527856204274308 -0.8673523617229679 LDLDLTADSQPPVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDLDLTADSQPPVFK 15 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 5581700.0 2138900.0 2205100.0 1237700.0 False True 2804118.6131370673 1876107.6754124796 1109634.6768567443 1.0 0.6690543212484193 0.3957160270104825 21.419115945407864 -7.445173840944769 0.2051161265036868 1.1863165728020506 1.883419904493863e-16 0.9999546617183244 0.0016636125559686937 0.1243249593329694 0.017325539173557974 0.02769780663207743 0.06069500124596179 3.587782928430244e-08 7.445173840944769 -1.1863165728020504 down LDLDLTADSQPPVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDLDLTADSQPPVFK 15 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 30899700.0 8532100.0 4391600.0 17976000.0 False True 8261253.155735422 6145188.78189146 13267546.331559472 1.0 0.7438567328765524 1.6059968241438531 22.977929211070048 -6.82709777738606 1.3407330745884176 0.862828810244098 1.6278641985555131 0.8999479787382278 0.1143454266963291 0.18443173551857664 0.6493806034552405 0.06697983439252553 0.15417767739232383 1.489025799582317e-07 6.82709777738606 0.7650353883114152 LDLDLTADSQPPVFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDLDLTADSQPPVFK 15 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 84801000.0 12006000.0 53311000.0 19484000.0 False True 18213979.756170776 43797235.529255874 15632978.859859435 1.0 2.4045944991466053 0.8582956096985386 24.118542849962783 -6.667579729387314 1.9460423326246528 1.8983980035740222 0.8646118347329189 0.26838567365049026 0.5969740053080134 0.46666256248352866 3.404828292980734 0.24717294160849837 0.6624536800755944 2.1499099546874997e-07 6.667579729387314 -1.0337861688411034 LDLDLTADSQPPVFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDLDLTADSQPPVFK 15 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 18472200.0 8532100.0 5056400.0 4883700.0 False True 7094819.186118089 5029160.169583178 5904859.090322492 1.0 0.7088496602455163 0.8322776007986357 22.758334486504324 -10.120641844416921 5.029384549764177 1.0000086702563036 0.7705636306858412 0.8216576065688264 0.05038924572830967 4.898936389773015e-06 8.565445157467259e-07 0.04879102064423427 0.016263059127518277 7.574573002110991e-11 10.120641844416921 -0.22944503957046236 LDLDLTADSQPPVFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDLDLTADSQPPVFK 15 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 36385000.0 12006000.0 11214000.0 13165000.0 False True 15542003.673641253 10589931.042101743 10769105.08430723 1.0 0.6813748899095894 0.6929032646267669 23.889669172055232 -9.889514986589923 5.361003437081477 1.0000003483672706 0.6871390772711043 0.9989826897823135 0.004706439279589562 6415628.93347684 2.989736281170216 27.58918406167307 0.001611139347896766 1.289689052671872e-10 9.889514986589923 -0.31286127109616624 LDLISK(ub)GEEPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDLISKGEEPR 11 1 Q99808;Q99808-2 Q99808 SLC29A1 Equilibrative nucleoside transporter 1 1 38195200.0 11842000.0 7990200.0 18363000.0 True False 15524976.678091135 6798093.305555662 16462972.910334012 1.0 0.43788106394704857 1.0604185276211446 23.888087765415584 -6.668847263702541 1.9412865839356699 0.6408512197663798 1.0578996146378603 0.2740258056537629 0.23883866002433923 0.46376848260406284 3.368343879261836 0.09908198198764916 0.26513745769198827 2.1436443632560287e-07 6.668847263702541 0.4170483948714805 LDLISK(ub)GEEPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDLISKGEEPR 11 1 Q99808;Q99808-2 Q99808 SLC29A1 Equilibrative nucleoside transporter 1 1 36181300.0 6880300.0 9960000.0 19341000.0 True False 6661888.642585809 13937079.940713858 14275011.882437212 1.0 2.0920613790542415 2.1427875259254368 22.667499808035938 -10.89717508797847 0.5472382620497486 2.9253162930561125e-21 2.1385798846459028 0.9998401484245971 0.006665083099298686 2.62026497220575 0.2666232375524054 3.372590976009287 0.009508817745330002 1.2671409087133027e-11 10.89717508797847 2.1385798846459028 LDLISK(ub)GEEPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDLISKGEEPR 11 1 Q99808;Q99808-2 Q99808 SLC29A1 Equilibrative nucleoside transporter 1 1 91493000.0 13293000.0 38026000.0 40174000.0 True False 20166452.848473918 31239963.201505903 32233591.291110285 1.0 1.549105508848571 1.5983768456111775 24.265454009542985 -11.552188090184023 0.3996030909692188 1.5952739239060772e-11 1.6018697929754537 0.9996677417144334 0.004943620772685925 4.113372041528652 0.20105739811977105 3.5503118104183335 0.01260667588651541 2.8042188855165365e-12 11.552188090184023 1.601869792959501 LDLISK(ub)GEEPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDLISKGEEPR 11 1 Q99808;Q99808-2 Q99808 SLC29A1 Equilibrative nucleoside transporter 1 1 40873100.0 11842000.0 8842100.0 20189000.0 True False 16220307.418017073 8451426.785085429 15420774.005506735 1.0 0.5210398648608728 0.9507078755102855 23.951297826938475 -10.3480176663799 8.46232894575087 1.000000802642947 0.7358738701855793 0.3350370713877945 0.17541123081463159 2.6561856830768885e-06 2.0486437556970699e-07 0.16984170763883819 0.056613731306901116 4.4872713608551e-11 10.3480176663799 -0.26412693245736774 LDLISK(ub)GEEPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDLISKGEEPR 11 1 Q99808;Q99808-2 Q99808 SLC29A1 Equilibrative nucleoside transporter 1 1 29424300.0 6880300.0 11102000.0 11442000.0 True False 5721274.298970739 11042191.32242554 13834469.29816941 1.0 1.9300230587462022 2.4180748160699514 22.447905083470214 -9.383693964949053 0.18298689308042296 2.5309490209071514e-21 2.9835494645862934 0.9996139345586436 0.011557757835576957 0.8198037993262217 0.07022714748417669 0.762001559827606 0.31117238238002837 4.1333866747066575e-10 9.383693964949053 2.9835494645862934 LDLISK(ub)GEEPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDLISKGEEPR 11 1 Q99808;Q99808-2 Q99808 SLC29A1 Equilibrative nucleoside transporter 1 1 76930000.0 13293000.0 27038000.0 36599000.0 True False 17208050.544203978 25533311.531687837 29938357.53745237 1.0 1.4838003564725684 1.739787866181984 24.036580331635435 -10.376436569650348 0.1294383513042259 7.590450473565978e-16 2.2059325050081195 0.999802326673837 0.004312835951021731 2.1622567786398306 0.06710901081635372 0.9752315155004088 0.2840470824586479 4.203039101684305e-11 10.376436569650348 2.2059325050081187 LDLITVEAFKPILSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDLITVEAFKPILSTR 16 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 0 6819200.0 2458200.0 4361000.0 0.0 False True 3222724.0052426658 3710355.799044858 0.0 1.0 1.1513104420387605 0.0 21.619849210307056 -6.935591228476544 1.2298637120095208 1.0817432290482454 1.3110685427691323e-21 0.9665006900977452 0.09349398889476254 0.11415386652721982 0.3444168762346976 0.06288196149704249 0.12100891178417604 1.159868547026436e-07 6.935591228476544 -1.0817432290482454 down LDLITVEAFKPILSTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDLITVEAFKPILSTR 16 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 0 22199100.0 11632000.0 6433600.0 4133500.0 False True 11262748.527034888 9002570.030780785 3050812.347658045 1.0 0.7993226528294747 0.27087636204741083 23.425055605523585 -6.9543388958792995 0.5089862499326439 1.0098072653137387 0.037248026445447155 0.9994992618613039 0.006881553807161657 0.0817888379132223 0.029103309419336264 0.007940143295497998 0.04361107046909953 1.1108645407183991e-07 6.9543388958792995 -0.9725592388682915 down LDLITVEAFKPILSTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDLITVEAFKPILSTR 16 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 0 19878000.0 4099100.0 10839000.0 4939900.0 False True 6218634.384351114 8904695.76450646 3963526.5997649166 1.0 1.4319374985148967 0.6373628605243196 22.56816636780972 -6.759055920461582 1.615817404918369 1.2511818114965332 0.6345724503551535 0.6872060978760536 0.18165113403445823 0.2844936321201953 1.463687714379816 0.08870639005499331 0.21339218455029943 1.7415826099532963e-07 6.759055920461582 -0.6166093611413797 LDLITVEAFKPILSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDLITVEAFKPILSTR 16 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 0 25003400.0 2458200.0 7216200.0 15329000.0 False True 3367062.9703571685 6897364.423217718 11708605.910664853 1.0 2.0484809710838476 3.4773943979499844 21.683059271829947 -6.966801787668611 0.32565037534769026 0.8168431325572397 4.755507593513598 0.999945613216974 0.007488007471245933 0.07735474865862382 0.01273194501727923 0.021185634200883773 0.12507977592658037 1.0794392667236104e-07 6.966801787668611 3.938664460956358 LDLITVEAFKPILSTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDLITVEAFKPILSTR 16 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 0 18484100.0 11632000.0 2894300.0 3957800.0 False True 9672523.384972697 2878707.8314264296 4785357.681200391 1.0 0.2976170454029412 0.4947372563228906 23.20546088095786 -10.346998149568673 5.2545904928911105 1.0002236929144717 0.3961771508631146 0.9259867835622021 0.08047398912406012 0.00021096284267677737 2.621676441984875e-05 0.07794689203077285 0.025972868306680275 4.497817713083967e-11 10.346998149568673 -0.604046542051357 LDLITVEAFKPILSTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDLITVEAFKPILSTR 16 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 0 11160200.0 4099100.0 4408600.0 2652500.0 False True 5306365.75534089 4163257.5345291416 2169772.216948339 1.0 0.7845779440172961 0.40889986046748655 22.33929268990217 -6.962633129034608 0.39658212564398726 1.0214463342331348 0.15838946277941485 0.9998557375887059 0.0029337114863117572 0.0787735844628982 0.017751558006618463 0.004837149210162779 0.03151674367837018 1.0898503574320149e-07 6.962633129034608 -0.8630568714537199 down LDLK(ub)DIPNAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDLKDIPNAIR 11 1 Q92508 Q92508 PIEZO1 Piezo-type mechanosensitive ion channel component 1 1 35913700.0 4315700.0 14672000.0 16926000.0 True False 5657924.493298247 12482994.791008057 15174659.88565668 1.0 2.2062851502868295 2.6820188045335187 22.431841492988166 -9.796020139192898 0.24343249296749464 1.7366081842550423e-16 2.9753477535665094 0.9991353387368727 0.020817113350815875 1.2243617657822277 0.10524337401885084 1.0906432262246588 0.21878227646338466 1.5994838553010986e-10 9.796020139192898 2.9753477535665094 LDLK(ub)DIPNAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDLKDIPNAIR 11 1 Q92508 Q92508 PIEZO1 Piezo-type mechanosensitive ion channel component 1 1 56028500.0 5016500.0 19643000.0 31369000.0 True False 4857253.953393272 27486552.33689176 23152517.850171857 1.0 5.658866635476139 4.766585826544551 22.21170948655326 -9.995683711999552 5.714483395402387 0.9999923195421055 5.212726231012262 0.9674488811284032 0.36427211486681305 3.5647152638749147e-05 6.265142360549512e-06 0.3527056065844386 0.11756831952958918 1.0099881725185218e-10 9.995683711999552 4.212733911470156 LDLK(ub)DIPNAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDLKDIPNAIR 11 1 Q92508 Q92508 PIEZO1 Piezo-type mechanosensitive ion channel component 1 1 201192000.0 10419000.0 107850000.0 82923000.0 True False 15806384.730929803 88603324.86410388 66533232.703557976 1.0 5.605540189764306 4.209263144997749 23.914004093439132 -9.601171712683488 7.054925477390366 1.0000775921009344 4.907401618321817 0.9126004812736 0.5700277183082775 6.85279100098059e-09 0.0 0.5519269723958683 0.18397565472405122 2.505118575735148e-10 9.601171712683488 3.9073240262208824 LDLK(ub)DIPNAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDLKDIPNAIR 11 1 Q92508 Q92508 PIEZO1 Piezo-type mechanosensitive ion channel component 1 1 33918700.0 4315700.0 11272000.0 18331000.0 True False 5911330.917407213 10773965.768480673 14001595.338795569 1.0 1.8225956081657286 2.3686028636232823 22.495051554511058 -8.281547327414577 0.14424675355827124 4.257816757951152e-15 3.47106765614179 0.9999318578986475 0.004643501436993859 0.09064824235822978 0.03123155919876902 0.33826019304148697 0.3398567779183063 5.229409753753148e-09 8.281547327414577 3.4710676561417855 LDLK(ub)DIPNAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDLKDIPNAIR 11 1 Q92508 Q92508 PIEZO1 Piezo-type mechanosensitive ion channel component 1 1 43784500.0 5016500.0 16698000.0 22070000.0 True False 4171442.01863098 16608044.559706518 26684734.95984955 1.0 3.9813677106213476 6.397004882404473 21.992114761987537 -7.739693606385683 0.2653535648375504 2.5974779110641206e-19 8.543920154190522 0.9996455378303313 0.041558130558013974 0.13232673388490782 0.03962877148786219 0.3312137609313182 0.6479033844054329 1.8209851057411643e-08 7.739693606385683 8.543920154190522 LDLK(ub)DIPNAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDLKDIPNAIR 11 1 Q92508 Q92508 PIEZO1 Piezo-type mechanosensitive ion channel component 1 1 121621000.0 10419000.0 76885000.0 34317000.0 True False 13487600.889194412 72606282.16265333 28071658.122155022 1.0 5.3831873258365635 2.0812936527981507 23.68513041553158 -6.5740559537256065 2.2905802405032767 3.995493265433415 2.0887298058641934 0.0 1.9070625510012147 0.7174297264479818 7.071774243200911 0.7017664030733494 2.13495887541369 2.6665150933458986e-07 6.5740559537256065 -1.9067634595692216 LDLLEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDLLEDR 7 0 Q14697;F5H6X6;Q14697-2;E9PKU7;E9PNH1 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 10338000.0 3830200.0 1021900.0 5485900.0 False True 3708612.397545479 1429949.9991380982 4048978.2165277037 1.0 0.3855754783337567 1.0917771345443092 21.822448063005027 -6.6766802663013305 1.9134428640290821 0.6101021516366586 1.0890402420838359 0.3091154391027343 0.260597357304686 0.44593260615478697 3.1535932386653873 0.10939330830979435 0.28977577923360887 2.105327841283908e-07 6.6766802663013305 0.4789380904471773 LDLLLEKTK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDLLLEKTK 9 1 Q96JB5;Q96JB5-4;Q96JB5-2;J3QRM1;Q96JB5-3 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 49569600.0 1783600.0 11735000.0 36051000.0 True False 2705851.598626204 9640797.564026525 28925504.04828537 1.0 3.562943943016418 10.689981691150846 21.367651286762428 -6.953142954822762 0.5232043894686998 0.8818229423896404 13.69090323536788 0.9994254008456541 0.09827023237443626 0.08224773364453287 0.030925425445170632 0.11076821788148009 0.5888919771704292 1.1139278064744221e-07 6.953142954822762 12.80908029297824 LDLSVTEAVVAGIAK(ub)ACGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDLSVTEAVVAGIAKACGK 19 1 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 16971800.0 2447200.0 4501600.0 10023000.0 True False 3167948.641523806 4251082.002775577 8198916.844664737 1.0 1.3419036997805545 2.5880838903755077 21.595117516099172 -6.947012860404903 0.5907282777974259 0.9856269258229017 3.0071452806507666 0.9989455342866811 0.02216149498327506 0.08470786228066136 0.04110073783013998 0.022958418730100783 0.1044217253513163 1.1297624594519723e-07 6.947012860404903 2.021518354827865 up LDLVHTAALMLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDLVHTAALMLDK 13 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 1635780.0 441180.0 609850.0 584750.0 False True 578391.2523931969 518862.75717668165 524245.6793180744 1.0 0.8970791916886615 0.9063859059916872 19.141686207527385 -10.36321924296873 5.707832605745018 1.0000227914378164 0.901732548840174 0.9933177328229329 0.0037994502040471652 1.1022146689970815e-06 1.2296508342955839e-07 0.0036796547532065575 0.0012262672804180582 4.332920862324929e-11 10.36321924296873 -0.09829024259764241 LDLVHTAALMLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDLVHTAALMLDK 13 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 2387570.0 441180.0 880590.0 1065800.0 False True 604296.1684412062 841682.6220782809 814079.9908400151 1.0 1.3928313069556897 1.347153984014081 19.204896269050277 -10.050648738705828 4.361492031673192 0.9999735352869678 1.3699926455091347 0.9886983918939636 0.018647689176589842 2707907.2635049685 2080039.4761591984 606.2211619596666 0.006383600000507296 8.89920602666084e-11 10.050648738705828 0.37001911022216694 LDMEIDGQK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDMEIDGQKLR 11 1 G5E975;Q12824-2;Q12824;A0A0G2JSE9;C9JTA6;A0A0G2JRV3;B5MCL5 G5E975 SMARCB1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 1 25039800.0 3134900.0 6989900.0 14915000.0 True False 4755872.4918890335 5742497.732662028 11967043.712523283 1.0 1.2074540985814164 2.5162667276998363 22.181278605310744 -6.93478237847919 0.7064399069715314 0.9831835267136461 2.820898154190071 0.9973974305197865 0.034243668768413546 0.0902295611811593 0.06606646573918593 0.032138384961265164 0.11547003590053534 1.1620307523704575e-07 6.93478237847919 1.8377146274764251 up LDMEIDGQK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDMEIDGQKLR 11 1 G5E975;Q12824-2;Q12824;A0A0G2JSE9;C9JTA6;A0A0G2JRV3;B5MCL5 G5E975 SMARCB1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 1 4771740.0 923250.0 753490.0 3095000.0 True False 1264600.4748931127 720198.320341776 2364024.7435258473 1.0 0.5695066027890343 1.8693846716494875 20.270250235721463 -6.817458098225247 1.3829570648911877 0.7673562828122839 1.8962180546437961 0.878410818774168 0.1885268471531894 0.19680524463123245 0.740308770532972 0.10714661309081552 0.24712430926381698 1.5224460150428539e-07 6.817458098225247 1.1288617718315122 LDMEIDGQK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDMEIDGQKLR 11 1 G5E975;Q12824-2;Q12824;A0A0G2JSE9;C9JTA6;A0A0G2JRV3;B5MCL5 G5E975 SMARCB1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 1 29402900.0 3134900.0 5572000.0 20696000.0 True False 4058189.8481174363 5261913.301818351 16929540.35889271 1.0 1.296615855529606 4.171697479048743 21.952404927403194 -6.92671011541902 0.7733219611002915 0.9505346317070006 4.715349363020681 0.9958511746513712 0.09213238773755812 0.09438240451825976 0.08631591674924763 0.08234911550394355 0.265006851056473 1.1838314805359387e-07 6.92671011541902 3.76481473131368 up LDNLVAILDINR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDNLVAILDINR 12 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 38732000.0 11718000.0 14765000.0 12249000.0 False True 11346018.5041089 20660741.49845782 9040619.437876724 1.0 1.820968429672104 0.7968098619443209 23.435682786211938 -6.693294331554153 1.8549919878063863 1.5131037097628657 0.8002284684060774 0.3857877650750341 0.3469836028715605 0.4096102062336037 2.7352673373114205 0.14950982734973206 0.387684655400827 2.026308976956506e-07 6.693294331554153 -0.7128752413567883 LDNLVAILDINR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDNLVAILDINR 12 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 143824000.0 16222000.0 82592000.0 45010000.0 False True 24609959.987056658 67852812.30575871 36113753.7714162 1.0 2.757128103477014 1.4674446358470246 24.552738976354547 -6.566710512237968 2.319466645338613 2.2059644441554065 1.469899951046044 0.0 0.7659084544579797 0.7402275977371996 7.4714075231155 0.27964189394947425 0.8595631744294793 2.71199876710808e-07 6.566710512237968 -0.7360644931093625 LDNLVAILDINR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDNLVAILDINR 12 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 25603800.0 11718000.0 6001000.0 7884800.0 False True 9744036.195418673 5968671.421894755 9533475.224803885 1.0 0.6125461053501658 0.9783907852565463 23.216088061646214 -10.57737031939764 9.182696539422865 1.0000269079251947 0.7954684461285193 0.2941545195241654 0.149355465147079 8.228689524190362e-05 3.787387397007663e-06 0.14463178595536558 0.048204269098308265 2.646242746492864e-11 10.57737031939764 -0.20455846179667536 LDNLVAILDINR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDNLVAILDINR 12 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 67807000.0 16222000.0 24453000.0 27132000.0 False True 20999698.783425648 23092169.05408543 22194254.397829376 1.0 1.099642870702093 1.0568844166158493 24.323865298446997 -10.409145319235424 6.2491069348208255 0.9999841097882363 1.0782636436588835 0.8170839361913987 0.01745606578358678 3.866338699056888e-06 3.6557302015535956e-07 0.01690519464946114 0.005633921005844368 3.898115300525993e-11 10.409145319235424 0.07827953387064723 LDPELHLDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDPELHLDIK 10 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 7669200.0 2324600.0 3073400.0 2271200.0 False True 3047573.1114584245 2614860.700019366 2036198.0108887758 1.0 0.8580140998710996 0.6681375430282451 21.539229400923816 -6.967095355018149 0.32006409944374836 1.0259840070058697 0.49404276032413097 0.9999500436720586 0.000960886454317577 0.07725700148253638 0.012390147325223089 0.002877407430191982 0.016701015032646656 1.0787098514088944e-07 6.967095355018149 -0.5319412466817387 LDPELHLDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDPELHLDIK 10 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 9907100.0 2324600.0 3196500.0 4386000.0 False True 3184067.439952922 3055268.0605880483 3350117.132505452 1.0 0.9595487904091698 1.052150180762184 21.602439462446707 -6.787957240975583 1.5043322099802043 0.9773317504646364 1.0530824763376856 0.7946883154308194 0.01717516546682058 0.23840833629915617 1.0658488823830694 0.008987429526277499 0.021074886633735593 1.6294564549831792e-07 6.787957240975583 0.07575072587304921 LDPGLIMEQVK(ub)VQIAVANAQELLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDPGLIMEQVKVQIAVANAQELLQR 25 1 Q9Y5L4 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 1 47247000.0 18356000.0 12171000.0 16720000.0 True False 27847394.00335421 9998989.957542967 13415284.671363665 1.0 0.3590637585814526 0.481742911733421 24.731038988748157 -9.501661469236772 12.49530776420881 1.0000004893741448 0.4204033245332113 0.9674914073160072 0.05008355455064323 0.0 0.0 0.048493193173018895 0.016164397724339627 3.150202927527786e-10 9.501661469236772 -0.5795971648409335 LDPGSEETQTLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDPGSEETQTLVR 13 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 40981000.0 1304000.0 24134000.0 15543000.0 False True 1709556.6279539627 20533301.27359518 13934759.458983919 1.0 12.010892729637108 8.15109557128936 20.705190781224037 -9.712209136975353 8.647559314843146 1.0000017893940902 10.08099415037712 0.8806731463296829 1.575755591433089 0.0 0.0 1.5257187908282375 0.5085729302760791 1.9399514579762107e-10 9.712209136975353 9.080992360983029 LDPGSEETQTLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDPGSEETQTLVR 13 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 34469300.0 9605200.0 4048100.0 20816000.0 False True 9300288.18362065 5664527.440562617 15363665.133385712 1.0 0.6090700985522997 1.651955813632063 23.148843990344716 -6.80515519593506 1.4345959691355141 0.7856913558738108 1.6682823518058485 0.8468491573813797 0.16834823464447027 0.213482721736568 0.8667616129434722 0.09229200725636641 0.21401675864929945 1.5661912887455503e-07 6.80515519593506 0.8825909959320377 LDPGSEETQTLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDPGSEETQTLVR 13 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 41778000.0 1304000.0 23849000.0 16625000.0 False True 1786124.0392749745 22795272.321903445 12698517.402622692 1.0 12.762424009004732 7.1095383766164915 20.768400842746928 -9.527121992841595 11.026564852602297 0.999989773083525 9.935981192810612 0.7691506808035651 2.307780895617786 0.0 0.0 2.2344992438524174 0.744833081284139 2.970831411250452e-10 9.527121992841595 8.935991419727086 LDPHLVLDQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDPHLVLDQLR 11 0 P35579;P35579-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 18973500.0 2818700.0 9010800.0 7144000.0 False True 3695342.9963296317 7666423.7638233015 6404807.4100869205 1.0 2.0746176394012443 1.7332105345697115 21.817276848753238 -10.062440565192544 4.4222038540851365 0.9999380013290478 1.9039140869448825 0.9033487421598659 0.13937886718721854 16015009.479786927 7288228.881246443 9514.043402782092 0.04771309494019229 8.660828418928819e-11 10.062440565192544 0.9039760856158348 LDPHLVLDQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDPHLVLDQLR 11 0 P35579;P35579-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 12531500.0 4005300.0 3332200.0 5194000.0 False True 3878153.943890372 4662764.837193443 3833535.5833399976 1.0 1.202315561644773 0.9884949485771017 21.88693864189707 -6.658699599651029 1.9779649623352868 1.1303688839371537 0.9893959826977521 0.22997697797396932 0.08616848318519983 0.4874834290242013 3.665091007073382 0.035217152457628145 0.09548155506654732 2.1943222174367395e-07 6.658699599651029 -0.14097290123940165 LDPHLVLDQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDPHLVLDQLR 11 0 P35579;P35579-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 16777600.0 2818700.0 7781900.0 6177000.0 False True 3860849.562503356 7438069.92669799 4718119.819308289 1.0 1.9265371018173476 1.2220418700409252 21.88048691027613 -10.180127848322144 4.69962811985016 0.999919458655444 1.5742894859329895 0.46978340267365304 0.28760897402598196 201788983.29613274 26.415531643600595 175878.85495790085 0.09845620175734117 6.604989806115702e-11 10.180127848322144 0.5743700272775455 LDPHLVLDQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDPHLVLDQLR 11 0 P35579;P35579-2;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 5112900.0 4005300.0 1107600.0 0.0 False True 3330584.41487544 1101633.1389586122 0.0 1.0 0.33076271360616816 0.0 21.667343917331348 -8.591146310499639 0.503945577767001 1.059826068631516 6.461522027511201e-21 0.9940630652253503 0.03205114738474434 0.2637302160211257 0.18707117809066084 0.09138771111553116 0.06467998599067151 2.5636202269125424e-09 8.591146310499639 -1.059826068631516 LDPITGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDPITGR 7 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 13786400.0 4061900.0 1228100.0 8496400.0 False True 3932957.2078716466 1718486.734456896 6270937.953463602 1.0 0.4369451900003941 1.594458729658331 21.90718305859833 -6.774426646109391 1.5574226394641235 0.6788764215985859 1.602100735657479 0.7472283136176109 0.23761176425967737 0.25933351688789325 1.241954422327682 0.12021297297048314 0.2850210167160479 1.6810218323288232e-07 6.774426646109391 0.9232243140588932 LDPSIFESLQK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDPSIFESLQKER 13 1 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 1 7574600.0 2234800.0 2349500.0 2990300.0 True False 2929844.4418339846 1998963.7582792682 2680892.440983048 1.0 0.6822764136337504 0.9150289355652272 21.482392637059625 -10.167409424532236 6.187592537983804 1.0000014197587588 0.7986526759862161 0.499448343618628 0.0950208191796814 1.8610685088741634e-06 2.504837215319107e-07 0.09200416167122656 0.030667837518823893 6.801278761332421e-11 10.167409424532236 -0.20134874377254264 LDPSIFESLQK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDPSIFESLQKER 13 1 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 1 11032600.0 3408300.0 4645800.0 2978500.0 True False 3300105.382109094 6500892.167526952 2198341.4969153213 1.0 1.9699044166196409 0.6661428173879598 21.65408066404336 -6.707531266282164 1.804160202220222 1.597788094612863 0.6694481801664371 0.4532592127457229 0.4088756905151038 0.3800807683710797 2.4101002943079037 0.18046146054949572 0.45980800331422766 1.960959994461483e-07 6.707531266282164 -0.9283399144464259 LDPSIFESLQK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDPSIFESLQKER 13 1 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 1 24410000.0 4196200.0 7669800.0 12544000.0 True False 6365942.183311989 6301064.26557908 10064672.901769493 1.0 0.989808591428464 1.5810185848299956 22.601942623528945 -6.902981849595887 0.9422552306377435 0.9773895243989618 1.646967961811943 0.9879912725781915 0.03028124819336002 0.10924311189079851 0.16531321634371232 0.023961631252584364 0.0633282973227545 1.2503112831976533e-07 6.902981849595887 0.6695784374129813 LDPSIFESLQK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDPSIFESLQKER 13 1 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 1 6505400.0 2234800.0 1869300.0 2401300.0 True False 3061065.953199167 1786708.1450515373 1834162.396325884 1.0 0.5836882224586574 0.5991907473960085 21.545602698582517 -9.814931469413153 6.478420533882889 1.0000000085878264 0.5914394849392504 0.9989213389222787 0.006328879303838272 7.861438346592433e-10 1.4094946759724203e-10 0.006127911127164654 0.0020426370119505897 1.5313290825306173e-10 9.814931469413153 -0.4085605236485761 LDPSIFESLQK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDPSIFESLQKER 13 1 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 1 10946100.0 3408300.0 4163400.0 3374400.0 True False 2834152.4632911296 4140970.937829802 4079971.438537216 1.0 1.4610967446053142 1.4395737319647908 21.434485939477636 -10.063389421957535 4.711321091465912 0.9999828597895537 1.4503352382944843 0.9982897785954603 0.008786733152461798 1095577.8867866385 2340156.1416111514 119.0674119837429 0.0030079325525545677 8.641926693952861e-11 10.063389421957535 0.4503523785049306 LDPSIFESLQK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDPSIFESLQKER 13 1 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 1 26327400.0 4196200.0 6974200.0 15157000.0 True False 5432063.619468046 6586079.63918549 12398581.52395326 1.0 1.21244523270706 2.2824809119535745 22.373068945621394 -6.939642944044529 0.6628869284721364 0.9879123389801333 2.568020138384118 0.9981166332321827 0.02435636646475527 0.08793008831834931 0.05535640120198691 0.023645304505410296 0.09224177247296003 1.1490979661162013e-07 6.939642944044529 1.5801077994039847 up LDQDK(ub)IEALSSK(ub)VQQLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDQDKIEALSSKVQQLER 18 2 Q12933-3;Q12933;Q12933-2;Q12933-4 Q12933-3 TRAF2 TNF receptor-associated factor 2 2 10282200.0 2878200.0 3007600.0 4396400.0 True False 2786833.1164470287 4208550.3644268 3244850.9508271045 1.0 1.5101551433378753 1.1643506500898801 21.410195181639274 -10.524762816428707 5.811823319031807 0.9994166071085194 1.3372528967138773 0.5591223950003028 0.14117409320321675 0.0010689425677508412 8.740826377331264e-05 0.1369193032018788 0.04556374265766596 2.987013487212916e-11 10.524762816428707 0.33783628960535783 LDQDK(ub)IEALSSK(ub)VQQLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDQDKIEALSSKVQQLER 18 2 Q12933-3;Q12933;Q12933-2;Q12933-4 Q12933-3 TRAF2 TNF receptor-associated factor 2 2 9507100.0 2878200.0 3022400.0 3606500.0 True False 2393350.825879336 3006117.731300575 4360602.475428067 1.0 1.2560288691467136 1.8219654336826894 21.19060045707355 -6.958042386353819 0.46220210454467847 0.9838617505046102 2.1170307933276225 0.9996905458643758 0.006041279781217002 0.08040804854725087 0.023772772008458662 0.007715232578254499 0.046741198921808204 1.1014318065486342e-07 6.958042386353819 1.1331690428230123 LDQDK(ub)IEALSSK(ub)VQQLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDQDKIEALSSKVQQLER 18 2 Q12933-3;Q12933;Q12933-2;Q12933-4 Q12933-3 TRAF2 TNF receptor-associated factor 2 2 19159000.0 3820200.0 5196800.0 10142000.0 True False 4945324.207399991 4907593.51164566 8296260.06570785 1.0 0.9923704302949697 1.6775968000831267 22.237633674145965 -6.904384957240861 0.9331519568136454 0.9748354876730801 1.756280669583873 0.9886236944779134 0.03426291348567946 0.10824894693480062 0.15978528282030208 0.02729483453394982 0.07271180998759473 1.2462783273716652e-07 6.904384957240861 0.7814451819107929 LDQELK(ub)LIGEYGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDQELKLIGEYGLR 14 1 P46781;B5MCT8;C9JM19;F2Z3C0;A8MXK4 P46781 RPS9 40S ribosomal protein S9 1 4593100.0 1192300.0 977500.0 2423300.0 True False 1563116.8462496244 831660.8102651569 2172560.1619349984 1.0 0.5320528738849915 1.3898898007193814 20.575994196160863 -6.758553270179601 1.6177142539092269 0.7277091045541321 1.3928260447935688 0.685141888066193 0.19678184987806974 0.2853390701297347 1.471369446518258 0.09598817801593178 0.23102400566543646 1.7435994759689628e-07 6.758553270179601 0.6651169402394367 LDQELK(ub)LIGEYGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDQELKLIGEYGLR 14 1 P46781;B5MCT8;C9JM19;F2Z3C0;A8MXK4 P46781 RPS9 40S ribosomal protein S9 1 17149900.0 3195200.0 5910700.0 8044000.0 True False 3093770.1249640537 8270873.333893298 5937035.0851727 1.0 2.6733962123282824 1.9190291603328744 21.5609345741606 -10.110156337410299 4.611592883798303 0.9998979176527817 2.296212686344667 0.7974331265517131 0.30796905945766717 18478834.46818342 40511824.665968046 11560.452260874274 0.10542600070380986 7.759677333330691e-11 10.110156337410299 1.2963147686918854 LDQELK(ub)LIGEYGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDQELKLIGEYGLR 14 1 P46781;B5MCT8;C9JM19;F2Z3C0;A8MXK4 P46781 RPS9 40S ribosomal protein S9 1 56405900.0 4800900.0 15123000.0 36482000.0 True False 7283316.29280362 12424182.493461678 29271316.709371395 1.0 1.7058414043802492 4.018954488945279 22.796164067795228 -6.949449370230549 0.5648555932359764 0.9704816429133719 4.865787143251506 0.9991573667286223 0.037428665120990676 0.08370759172972334 0.036883137777283755 0.039890106519994306 0.19249180813170533 1.1234419321733259e-07 6.949449370230549 3.895305500338134 LDQELK(ub)LIGEYGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDQELKLIGEYGLR 14 1 P46781;B5MCT8;C9JM19;F2Z3C0;A8MXK4 P46781 RPS9 40S ribosomal protein S9 1 6459200.0 1192300.0 1291100.0 3975800.0 True False 1633125.530695976 1234054.932903245 3036797.9241712643 1.0 0.7556399736016237 1.8595006122261137 20.639204257683755 -6.848634585634902 1.2415239695260774 0.8697243828678485 1.9025108559975468 0.9383047063138348 0.1175854430563869 0.158974490897193 0.47220673054362344 0.0741320042831476 0.1714171719119409 1.4169855268407296e-07 6.848634585634902 1.0327864731296983 LDQELK(ub)LIGEYGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDQELKLIGEYGLR 14 1 P46781;B5MCT8;C9JM19;F2Z3C0;A8MXK4 P46781 RPS9 40S ribosomal protein S9 1 12607600.0 3195200.0 3957100.0 5455300.0 True False 2656950.3713604505 3935782.3168771435 6595978.007542695 1.0 1.4813157066467473 2.4825371518570467 21.341339849594878 -6.959268736351528 0.4456192450254441 0.966227226921723 3.037028332255803 0.9997421113924052 0.009916764721595183 0.07996337136280113 0.022104277103098466 0.013298357734079001 0.08287463643711164 1.0983259978195104e-07 6.959268736351528 2.07080110533408 LDQELK(ub)LIGEYGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDQELKLIGEYGLR 14 1 P46781;B5MCT8;C9JM19;F2Z3C0;A8MXK4 P46781 RPS9 40S ribosomal protein S9 1 53496900.0 4800900.0 10554000.0 38142000.0 True False 6214859.689887079 9966660.622288378 31200547.36996936 1.0 1.6036823226285044 5.0203140419629095 22.567290389887678 -6.937083000419212 0.6861617306868028 0.9590330355132082 5.867644879324571 0.9977563633305249 0.08384654690125241 0.08912289429720212 0.06086029138731351 0.07991600047970217 0.2980377654160893 1.1558913123027564e-07 6.937083000419212 4.908611843811363 LDQLIYIPLPDEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDQLIYIPLPDEK 13 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 17269700.0 1748300.0 7972400.0 7549000.0 False True 2292038.2305612843 6782948.996171805 6767901.89512125 1.0 2.9593524687896533 2.952787525478533 21.12819967737239 -10.124528244824967 4.5745549118851505 0.9998066358312993 2.956069997179172 0.9999915520207918 0.002680127036528691 210165.00457501 232572.3197047928 337.49055671057715 0.0009174787589550339 7.507092293220558e-11 10.124528244824967 1.9562633613478728 LDQLIYIPLPDEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDQLIYIPLPDEK 13 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 19123100.0 9129100.0 3713200.0 6280800.0 False True 8839301.717516692 5195900.1240821965 4635670.060038866 1.0 0.5878179397118632 0.5244384916573713 23.07550097418227 -13.999999999999998 0.2635871432748183 4.074648978387347 0.5020574570759601 0.9995697366603187 0.004373341569672426 14.578767953967075 0.16248199586880618 23.92761180473405 0.0271949446117721 1.0000000000000041e-14 13.999999999999998 -3.572591521311387 LDQLIYIPLPDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDQLIYIPLPDEK 13 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 23748700.0 1748300.0 12362000.0 9638400.0 False True 2394693.7560310126 11815805.964332674 7362008.429078999 1.0 4.934161595642316 3.0743005908533623 21.19140973889528 -9.664934902129806 16.421712465196023 0.9999997412563915 4.004230442358752 0.7767318868842576 0.7592850757056937 0.0 0.0 0.735174613308243 0.24505820443608092 2.1630427252256357e-10 9.664934902129806 3.004230701102361 LDQLIYIPLPDEK(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDQLIYIPLPDEKSR 15 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 150396000.0 44503800.0 64400200.0 41492000.0 True False 58344912.775412284 54791941.19001339 37198805.859368175 1.0 0.939104003821629 0.6375672546218031 25.79810353379213 -6.940022556031289 0.6593572590955109 1.003383364435713 0.5561994016561062 0.9981667996506612 0.006784664621068126 0.08775646835184445 0.054563603909884205 0.006605466011072835 0.025950111679152253 1.148093991182492e-07 6.940022556031289 -0.4471839627796069 LDQLIYIPLPDEK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDQLIYIPLPDEKSR 15 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 297071000.0 137166600.0 116436100.0 43468300.0 True False 132812321.36420065 162929641.93624023 32082648.208952267 1.0 1.2267660128419202 0.2415637937761405 26.98481375477802 -6.846146565377733 1.2535830760575013 1.1207202309325721 0.20502050764055132 0.9345014122959475 0.1078162229050402 0.16174815718482707 0.4910835016644007 0.06736246003886882 0.15554100707740073 1.4251265617888147e-07 6.846146565377733 -0.9156997232920208 down LDQLIYIPLPDEK(ub)SR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDQLIYIPLPDEKSR 15 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 329062000.0 145308000.0 129543000.0 54211000.0 True False 220442859.43775296 106425039.52592137 43496172.08847461 1.0 0.48277834808241044 0.19731268320240938 27.715829505181222 -8.807700435668847 0.2517726990420311 1.2797321925595893 1.1079788760640605e-10 0.9992082668579043 0.009347850310439177 0.3311045851664397 0.07794258901556576 0.19361029469369997 0.11249754940544467 1.5570392639343943e-09 8.807700435668847 -1.2797321924487914 LDQLIYIPLPDEK(ub)SR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDQLIYIPLPDEKSR 15 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 132785200.0 44503800.0 49200700.0 39080700.0 True False 60958057.52997367 47026850.3890425 29850643.552281305 1.0 0.7714624168580001 0.48969151514717235 25.86131359531502 -6.9683105145918 0.2957705195717921 1.0513910308767005 0.2009865864148185 0.999966041031436 0.0012162300900340766 0.07685481239022914 0.01098202782806131 0.004775581961015306 0.025386422434382445 1.0756958308635362e-07 6.9683105145918 -0.850404444461882 down LDQLIYIPLPDEK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDQLIYIPLPDEKSR 15 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 267605100.0 137166600.0 96187400.0 34251100.0 True False 114060105.41069417 95669219.38449597 41412846.65080669 1.0 0.8387614498515632 0.36307915464124985 26.765219030212297 -6.95182681613045 0.5384178972860939 1.007077083475434 0.17285607376116394 0.9993369383772132 0.006962233451033147 0.08276043356349834 0.03299029481815955 0.007674413052945941 0.039383419776279245 1.1173087088164241e-07 6.95182681613045 -0.8342210097142699 down LDQWLTTMLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDQWLTTMLLR 11 0 P54920;M0R0Y2;M0R213;A0A087WZQ7;Q9H115-3;Q9H115-2;Q9H115 P54920 NAPA;NAPB Alpha-soluble NSF attachment protein;Beta-soluble NSF attachment protein 0 8258800.0 4582400.0 1817300.0 1859100.0 False True 3810468.6347402777 1807509.8441941943 2247829.21449281 1.0 0.47435368650328613 0.5899088616027993 21.861537009415162 -9.79391201576903 6.328198744226161 1.0000000109083602 0.5321312740529024 0.9562514037098153 0.04717520268947745 7.227642967771903e-09 1.3982434522203004e-09 0.04567719495348686 0.015225731197400536 1.6072668381145702e-10 9.79391201576903 -0.4678687368554578 LDRPAGGPSAESPRPSSAYNGDLNGLLVPDPLCSGDSTSANK(ub)TGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDRPAGGPSAESPRPSSAYNGDLNGLLVPDPLCSGDSTSANKTGLR 46 3 Q6P2E9 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 38459400.0 6105900.0 8306500.0 24047000.0 True False 7904207.915282857 7844235.972999656 19670692.743056275 1.0 0.992412656280556 2.4886355412061993 22.91418946594342 -6.905759111111562 0.9241449860856558 0.9472346264980035 2.6654257125142085 0.9892200148229476 0.07304672917845008 0.10728925738681908 0.1544790497944702 0.058577620341650184 0.1573196039360869 1.2423412023920217e-07 6.905759111111562 1.7181910860162048 up LDSAK(ub)LSSDQNDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDSAKLSSDQNDK 13 1 Q03252 Q03252 LMNB2 Lamin-B2 1 12183980.0 7340500.0 955750.0 3887730.0 True False 9623466.585503118 813155.8254843211 3485464.9933394776 1.0 0.0844971838640004 0.3621839346945949 23.198125247605347 -10.270393372435715 5.5226341039729 1.0000725905657826 0.2233405608209923 0.9125119215553543 0.11336514131114667 0.00010133226596846883 1.3387238078781415e-05 0.10977548985748961 0.0365884420281968 5.3654558742779876e-11 10.270393372435715 -0.7767320297447903 LDSAK(ub)LSSDQNDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDSAKLSSDQNDK 13 1 Q03252 Q03252 LMNB2 Lamin-B2 1 20656300.0 2953200.0 14280600.0 3422500.0 True False 4480220.307839702 11732115.355162939 2746041.374864961 1.0 2.6186469747109373 0.6129255228944451 22.095138245627837 -6.691930162660446 1.8593680036748137 2.0129332922036958 0.6196545275193369 0.3795648928548049 0.6843057128086522 0.41253092105335737 2.7666247063318132 0.29424435002903226 0.7644271864655214 2.0326838532636644e-07 6.691930162660446 -1.393278764684359 LDSAK(ub)LSSDQNDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDSAKLSSDQNDK 13 1 Q03252 Q03252 LMNB2 Lamin-B2 1 4666670.0 1820900.0 2194500.0 651270.0 True False 1514159.0295475225 2182677.792925855 787447.5458677495 1.0 1.4415115918029473 0.5200560380391901 20.530085306411863 -6.776410147581137 1.549735037691337 1.2511662368745367 0.5135496630640065 0.7544908335052569 0.1864483315424908 0.2562110596526691 1.2151114206193177 0.09478081306295423 0.22433471968370797 1.673361807164323e-07 6.776410147581137 -0.7376165738105301 LDSAK(ub)LSSDQNDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDSAKLSSDQNDK 13 1 Q03252 Q03252 LMNB2 Lamin-B2 1 10147800.0 2953200.0 3832400.0 3362200.0 True False 3822975.616274969 3619123.571049653 2750314.0990852853 1.0 0.9466771264882026 0.7194171177490104 21.866264567720286 -6.943419979216416 0.6269419139880762 1.002479697003865 0.6514305577008641 0.9985783871658861 0.004587216215381285 0.08624054629767305 0.04776112223437409 0.004590849628482304 0.01928464420171652 1.1391476558078836e-07 6.943419979216416 -0.35104913930300086 LDSEDKDKEGK(ub)PLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDSEDKDKEGKPLLK 15 3 P13639 P13639 EEF2 Elongation factor 2 1 3593470.0 1126900.0 1679300.0 787270.0 True False 1477376.8129151245 1428754.9858601312 705810.8524270895 1.0 0.9670890820608902 0.4777459929362235 20.494606409503188 -6.920532980051143 0.8207663303794142 1.0105910894494952 0.3978600411025442 0.9943276174133506 0.017986326557775566 0.09785931432896497 0.10399753014463495 0.01554092229657848 0.04679214543855408 1.2007898823201104e-07 6.920532980051143 -0.612731048346951 down LDSEDKDKEGK(ub)PLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDSEDKDKEGKPLLK 15 3 P13639 P13639 EEF2 Elongation factor 2 1 34921500.0 6453500.0 12504000.0 15964000.0 True False 9790431.314046977 10272563.505802082 12808708.402730232 1.0 1.0492452453104244 1.3082884698197856 23.222940987981524 -6.938679755290592 0.6717331160226506 0.9970153093563999 1.375512251379798 0.9979858232985124 0.0060688027201078985 0.08837408987130142 0.05739126673848379 0.00585003252641556 0.02242811922856854 1.1516492913898022e-07 6.938679755290592 0.378496942023398 LDSEDKDKEGK(ub)PLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDSEDKDKEGKPLLK 15 3 P13639 P13639 EEF2 Elongation factor 2 1 3773000.0 1126900.0 1070200.0 1575900.0 True False 1543545.3833274315 1022915.0253218597 1203704.8766792836 1.0 0.6627048588080738 0.7798312182337319 20.55781647102608 -10.352466048956034 4.921521020225214 1.0001812737084952 0.7212680385208158 0.8830542598813472 0.04781663600408197 9.516899949388374e-05 1.2521517069464213e-05 0.046328171149317025 0.015432752909579645 4.4415438185173e-11 10.352466048956034 -0.2789132351876794 LDSEDKDKEGK(ub)PLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDSEDKDKEGKPLLK 15 3 P13639 P13639 EEF2 Elongation factor 2 1 36979500.0 6453500.0 12288000.0 18238000.0 True False 8354182.967503226 11604161.997979878 14918871.137682874 1.0 1.3890241622811808 1.7857965519447563 22.994067310073973 -6.970879478766626 0.2362467365579241 0.850731329835395 2.3355124152804727 0.999988450659617 0.0010902197163341484 0.07601840606549437 0.008002298522709264 0.009741713381681808 0.03894486220308685 1.0693515942336933e-07 6.970879478766626 1.4847810854450776 LDSEYK(ub)EGGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDSEYKEGGQR 11 1 F8VRE8;F8VS20;Q96HH6-2;Q96HH6 F8VRE8 TMEM19 Transmembrane protein 19 1 4876920.0 577610.0 553040.0 3746270.0 True False 791168.0263233263 528604.8641412831 2861478.18285253 1.0 0.6681322381009093 3.6167768257145556 19.59362459770666 -6.8789420441270455 1.0857419783516198 0.7970820820579569 3.8215030406574977 0.972819389484191 0.21741801026584343 0.1285685817311317 0.2780169760639217 0.15440601283053929 0.37239207283008874 1.3214719706468677e-07 6.8789420441270455 3.0244209585995407 up LDSGK(ub)ELHINLIPNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDSGKELHINLIPNK 15 1 P07900;P07900-2;G3V2J8;Q14568 P07900 HSP90AA1;HSP90AA2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 88060200.0 42530000.0 40013000.0 5517200.0 True False 55757241.86110587 34043216.36945238 4946333.068719429 1.0 0.6105613411483977 0.088711939536769 25.732655861506085 -7.5937796553903345 0.526054736011855 1.011863825617772 3.7950780467433527e-25 0.9955059201454053 0.025027832607132896 0.11750162733471435 0.08847739822422852 0.027132612672637224 0.07303609934317976 2.5481227458728984e-08 7.5937796553903345 -1.011863825617772 down LDSGK(ub)ELHINLIPNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDSGKELHINLIPNK 15 1 P07900;P07900-2;G3V2J8;Q14568 P07900 HSP90AA1;HSP90AA2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 82847100.0 54600000.0 24347700.0 3899400.0 True False 52866752.88652892 34069863.58157818 2878030.160507511 1.0 0.6444478187397734 0.054439321565385335 25.655857382298567 -7.516327749652807 0.6082417483519599 1.0011812794255142 1.832301057433114e-23 0.9930351002555173 0.03254441016437728 0.11624113076703031 0.10420314774681694 0.030819165595217416 0.0723830672929315 3.0455956979656725e-08 7.516327749652807 -1.0011812794255142 down LDSGK(ub)ELHINLIPNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDSGKELHINLIPNK 15 1 P07900;P07900-2;G3V2J8;Q14568 P07900 HSP90AA1;HSP90AA2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 43594900.0 30809300.0 4292900.0 8492700.0 True False 46739960.56153523 3526798.4544192073 6814114.122517363 1.0 0.07545574305258604 0.14578775935307603 25.47815318100875 -10.47847019223765 5.993366431304979 1.000665835982331 0.1106217512028314 0.9953316626822287 0.028712925419552095 0.00025562622711830383 2.2244051577986405e-05 0.02781961788145115 0.009267056830901666 3.322995917807269e-11 10.47847019223765 -0.8900440847794997 LDSGK(ub)ELHINLIPNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDSGKELHINLIPNK 15 1 P07900;P07900-2;G3V2J8;Q14568 P07900 HSP90AA1;HSP90AA2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 78304600.0 42530000.0 32606500.0 3168100.0 True False 58254490.33003427 31165837.01472362 2419860.0290676043 1.0 0.5349945873383678 0.04153945928216279 25.795865923028977 -7.835321386448976 0.5414561020200239 1.0151754008629574 4.1724826873849825e-27 0.9927781476475214 0.03325727587596961 0.11130061368590033 0.12437757392630933 0.037532076650209495 0.07741815722621856 1.4610955348875788e-08 7.835321386448976 -1.0151754008629574 down LDSGK(ub)ELHINLIPNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDSGKELHINLIPNK 15 1 P07900;P07900-2;G3V2J8;Q14568 P07900 HSP90AA1;HSP90AA2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 98214200.0 54600000.0 39900000.0 3714200.0 True False 45402319.190122835 39685050.78047009 4490822.047479527 1.0 0.8740754104275685 0.09891173243098328 25.436262657732843 -7.041681933820976 0.7843852241364427 1.0032391764921094 2.19659192949503e-25 0.9965978685397127 0.02323935984826486 0.07774328731547311 0.07942708681080358 0.02142069783114682 0.05665079012208523 9.084856382571309e-08 7.041681933820976 -1.0032391764921094 down LDSGK(ub)ELHINLIPNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDSGKELHINLIPNK 15 1 P07900;P07900-2;G3V2J8;Q14568 P07900 HSP90AA1;HSP90AA2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 57803900.0 30809300.0 14199400.0 12795200.0 True False 39883246.19209688 13409190.907724235 10466604.889838796 1.0 0.33621112090874267 0.26243111805459857 25.2492795031012 -13.999999999999998 0.3101696675956483 7.422772367992968 0.24612163297420345 0.9996723692446647 0.006003481451418327 17.281841238921462 0.17721029623612997 71.6433308772954 0.02554967751709502 1.0000000000000041e-14 13.999999999999998 -7.1766507350187645 LDSGK(ub)ELHINLIPNKQDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDSGKELHINLIPNKQDR 18 2 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 247782000.0 53946000.0 103180000.0 90656000.0 True False 69834160.43463689 97437942.2974905 74157538.20911169 1.0 1.3952762042394724 1.0619092110160238 26.05742958938422 -10.303353978955206 6.180430202564729 0.9999886892797133 1.2285927076277483 0.3853449858289596 0.13609650508055166 2.121178025456621e-05 2.391021587619696e-06 0.13178139240757536 0.04392495813783408 4.9733156135963314e-11 10.303353978955206 0.228604018348035 LDSGK(ub)ELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDSGKELK 8 1 P08238;Q58FF7;Q58FF8 P08238;Q58FF7;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 1 175699990.0 71565000.0 84110000.0 20024990.0 True False 93822408.03644574 71561115.8582122 17952996.128067825 1.0 0.7627294732236457 0.1913508350914837 26.48342919358578 -7.097026832531727 0.5364839052669109 1.007144420077508 1.83530698410203e-24 0.9992828875217457 0.009088570136751137 0.076403697940249 0.03436138648761458 0.010011789386964644 0.04359808510365072 7.997848394239657e-08 7.097026832531727 -1.007144420077508 down LDSGK(ub)ELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDSGKELK 8 1 P08238;Q58FF7;Q58FF8 P08238;Q58FF7;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 1 164793500.0 75995000.0 71763500.0 17035000.0 True False 73582580.32255992 100419039.79170863 12573022.46095435 1.0 1.3647121282171295 0.17086955099751436 26.132860932439925 -6.824717256705769 1.3513088500396366 1.1956976180619454 0.14206700639081649 0.8948964788393405 0.161944563884813 0.18742259991499383 0.6711507008523446 0.09414191947028346 0.2167615043262348 1.4972100832571286e-07 6.824717256705769 -1.053630611671129 down LDSGK(ub)ELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDSGKELK 8 1 P08238;Q58FF7;Q58FF8 P08238;Q58FF7;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 1 21418550.0 946250.0 8475300.0 11997000.0 True False 1435530.4301413111 6962816.497178861 9625787.691528112 1.0 4.850344061667473 6.705387422947604 20.453152482208978 -8.74155341247879 0.344827135169545 2.808470372134896e-19 7.335928666111992 0.9980281711182194 0.10551670105282626 0.3011529739296272 0.11165551676572544 0.9442386900159188 0.5342099178081183 1.813203662081964e-09 8.74155341247879 7.335928666111992 LDSGK(ub)ELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDSGKELK 8 1 P08238;Q58FF7;Q58FF8 P08238;Q58FF7;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 1 156346000.0 71565000.0 63908000.0 20873000.0 True False 98024514.47140601 61084333.2445052 15943227.292928915 1.0 0.6231536424730126 0.16264530744071773 26.546639255108673 -7.52812124455022 0.43257031904581544 1.029130648965455 3.579183236916317e-13 0.998349008098776 0.013913219028002246 0.11868401356033835 0.057088666511374606 0.020663909372723936 0.06852003651976017 2.9640037955982952e-08 7.52812124455022 -1.029130648965097 down LDSGK(ub)ELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDSGKELK 8 1 P08238;Q58FF7;Q58FF8 P08238;Q58FF7;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 1 151712770.0 75995000.0 66095870.0 9621900.0 True False 63193209.649329506 65739798.42930702 11633794.803360973 1.0 1.0402984560225537 0.18409881169067047 25.9132662078742 -6.895857714578089 0.9871022826959575 1.0397552672754653 0.10142383058785422 0.9843897648765519 0.0492843439728499 0.11451827441256753 0.19512195203091873 0.037719555279144175 0.09624935784642916 1.2709904443471707e-07 6.895857714578089 -0.9383314366876111 down LDSGK(ub)ELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDSGKELK 8 1 P08238;Q58FF7;Q58FF8 P08238;Q58FF7;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 1 13807150.0 946250.0 8225600.0 4635300.0 True False 1224939.2783760638 7767838.129116475 3791722.9621944036 1.0 6.341406685410981 3.0954374874983164 20.224278804301427 -9.47887637941259 9.487901449037007 1.000004510795133 4.718422086454569 0.6363259491161208 1.3251613759487755 0.0 0.0 1.2830819659012407 0.4276939950068551 3.3198894373526376e-10 9.47887637941259 3.718417575659436 LDSIVIQQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDSIVIQQGR 10 0 O60264;A0A0A0MRP6;B7ZLQ5;P28370-2;P28370 O60264 SMARCA5;SMARCA1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Probable global transcription activator SNF2L1 0 3518210.0 645640.0 937170.0 1935400.0 False True 846440.2923866545 797347.8890600483 1735143.373667724 1.0 0.9420013392933085 2.0499300296483396 19.691048778924245 -6.894552833631465 0.9950792908097534 0.9468027961406247 2.1541687538108025 0.9836553419683979 0.06509457225238727 0.1155261185680657 0.20090023595985312 0.0495224806526271 0.1256632050982374 1.274815004251784e-07 6.894552833631465 1.2073659576701778 up LDSIVIQQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDSIVIQQGR 10 0 O60264;A0A0A0MRP6;B7ZLQ5;P28370-2;P28370 O60264 SMARCA5;SMARCA1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Probable global transcription activator SNF2L1 0 3714440.0 645640.0 1255900.0 1812900.0 False True 884350.5557649507 1200410.1852940791 1384730.357847497 1.0 1.3573917916020772 1.5658161221482187 19.754258840447136 -10.366164473436108 0.09705449941641646 2.4957339143108243e-09 2.152966663969661 0.999923499906928 0.0020435680355886457 2.1933594418016242 0.050992872780980185 0.857516702829707 0.3394037025971808 4.3036359487167026e-11 10.366164473436108 2.1529666614739273 LDSK(ub)VNIIPIIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDSKVNIIPIIAK 13 1 A0A087X142;A6NMH6;A6NFQ9;F8W8I8;Q92599-3;Q92599-2;Q92599-4;Q92599;C9JV02;D6RDU5;D6RGI3;D6RER5;Q9NVA2;Q9NVA2-2;Q14141;B1AMS2;Q14141-2;Q14141-4;Q14141-3 A0A087X142;D6RDU5;Q14141 SEPT8;SEPT11;SEPT6 Septin-8;Septin-11;Septin-6 1 3872130.0 1567400.0 1729400.0 575330.0 True False 2054876.578723193 1471380.2611484008 515800.3705550543 1.0 0.716043131925057 0.2510128228117473 20.970620313785275 -7.125213768312249 0.417080751269001 1.0235984432168048 3.101072060579418e-13 0.9997505621030449 0.0048760652561600885 0.0788445196919941 0.0225174687110336 0.007366130321656264 0.039356022864003616 7.49525187435235e-08 7.125213768312249 -1.0235984432164946 down LDSK(ub)VNIIPIIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDSKVNIIPIIAK 13 1 A0A087X142;A6NMH6;A6NFQ9;F8W8I8;Q92599-3;Q92599-2;Q92599-4;Q92599;C9JV02;D6RDU5;D6RGI3;D6RER5;Q9NVA2;Q9NVA2-2;Q14141;B1AMS2;Q14141-2;Q14141-4;Q14141-3 A0A087X142;D6RDU5;Q14141 SEPT8;SEPT11;SEPT6 Septin-8;Septin-11;Septin-6 1 5111900.0 1476400.0 1607900.0 2027600.0 True False 1429532.4901405007 2249942.8550877282 1496510.7333038484 1.0 1.5739011674135466 1.0468532500137613 20.447111978962237 -10.351597902293904 3.77066966458135 0.9988869497321401 1.3103772087664454 0.3161927352812617 0.21516641144478588 27749742.47169636 26437907.564340495 224473.95964275056 0.0736571852952914 4.4504312626797223e-11 10.351597902293904 0.3114902590343053 LDSPDPFK(ub)LNDPFQPFPGNDSPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDSPDPFKLNDPFQPFPGNDSPK 23 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 175460000.0 71702000.0 80731000.0 23027000.0 True False 69425859.25769044 112967309.30660337 16995537.904807504 1.0 1.6271647267237783 0.24480126118028384 26.048969792058863 -6.7833431982178425 1.5225461265592632 1.3535879506225024 0.23262771418325812 0.7790880389543652 0.26562948277825693 0.24544264032139618 1.1239544263627814 0.1373729416666414 0.3232893682483798 1.6468604570574735e-07 6.7833431982178425 -1.1209602364392444 LDSPDPFK(ub)LNDPFQPFPGNDSPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDSPDPFKLNDPFQPFPGNDSPK 23 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 66913000.0 19549000.0 29124000.0 18240000.0 True False 26776793.59186079 27837205.379811108 13932087.664591733 1.0 1.0396018957352924 0.5203045546434134 24.674479878567762 -6.888503782497096 1.031219432053239 1.0289116162527647 0.4769321214724802 0.9799222530137937 0.033442974691524005 0.1203644308308543 0.22901921134406303 0.02475804926469532 0.06139744348315719 1.292695441999084e-07 6.888503782497096 -0.5519794947802845 LDSPDPFK(ub)LNDPFQPFPGNDSPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDSPDPFKLNDPFQPFPGNDSPK 23 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 165478000.0 71702000.0 81998000.0 11778000.0 True False 59623389.93718295 81556260.49867125 14240725.344680931 1.0 1.3678568190201192 0.23884461047391714 25.82937506749314 -6.818952078332525 1.3764751033041058 1.1984691016455558 0.21475492494690795 0.8819802070816415 0.16151437954858114 0.1948171462951707 0.725588576205128 0.09221861195502903 0.21260319474035771 1.517217773671943e-07 6.818952078332525 -0.9837141766986478 down LDSQK(ub)HIDFSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDSQKHIDFSLR 12 1 P46781 P46781 RPS9 40S ribosomal protein S9 1 131488400.0 47434600.0 53507000.0 30546800.0 True False 62187219.95731988 45523964.16865238 27386110.161596168 1.0 0.7320469414760176 0.4403816440161131 25.89011478799787 -6.970039422466981 0.2572408792841628 1.0846935462429892 0.07911274050119944 0.999982688653583 0.0009508317173862951 0.07628989902895421 0.008984270800496633 0.006198823516623638 0.027634533688190667 1.0714220440035297e-07 6.970039422466981 -1.0055808057417897 down LDSQK(ub)HIDFSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDSQKHIDFSLR 12 1 P46781 P46781 RPS9 40S ribosomal protein S9 1 186480200.0 49378000.0 83083000.0 54019200.0 True False 47810522.418150626 116258475.17212129 39869950.978737034 1.0 2.4316503834725993 0.8339158194096816 25.510824834087845 -6.670521799121083 1.935649558320731 1.9134234780305281 0.8403826769978916 0.2812731138087129 0.6080641906794861 0.459941821252417 3.3228650588565736 0.2528621242163316 0.6750937714222386 2.1353948986384773e-07 6.670521799121083 -1.0730408010326364 LDSQK(ub)HIDFSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDSQKHIDFSLR 12 1 P46781 P46781 RPS9 40S ribosomal protein S9 1 301258000.0 82767000.0 62042000.0 156449000.0 True False 125563590.07820965 50970120.36364145 125526786.57596745 1.0 0.40593073463329415 0.9997068935173063 26.90384294284473 -10.887306206513697 10.530225441540257 1.0193343804527577 0.7028188140753003 0.2503702232600179 0.24240810178259709 0.09609348525869231 0.0010283844716297385 0.20497909659913208 0.07823687843247923 1.2962649956160467e-11 10.887306206513697 -0.31651556637745737 LDSQK(ub)HIDFSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDSQKHIDFSLR 12 1 P46781 P46781 RPS9 40S ribosomal protein S9 1 127033100.0 47434600.0 32436500.0 47162000.0 True False 64972453.49186564 31003348.176838495 36023306.931879185 1.0 0.47717681125771283 0.5544396893737312 25.95332484952076 -10.68449009097462 6.741314256472508 1.0036146473746639 0.5158082503158168 0.981260729073858 0.03154243790718232 0.0017209609414048474 8.054505247725459e-05 0.03067215383996712 0.01018027805944156 2.067806561229328e-11 10.68449009097462 -0.4878063970588471 LDSQK(ub)HIDFSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDSQKHIDFSLR 12 1 P46781 P46781 RPS9 40S ribosomal protein S9 1 140183900.0 49378000.0 59805000.0 31000900.0 True False 41059994.816298254 59482818.59463688 37483044.858033516 1.0 1.4486806162728962 0.9128847927461279 25.29123010952212 -6.68455199125322 1.8856152919671865 1.2827163216093376 0.9148413445256891 0.34510560272708213 0.18997510454386826 0.4284981746264285 2.9493687525262624 0.08072621428364864 0.211684110159993 2.0675118564007115e-07 6.68455199125322 -0.36787497708364847 LDSQK(ub)HIDFSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDSQKHIDFSLR 12 1 P46781 P46781 RPS9 40S ribosomal protein S9 1 303752000.0 82767000.0 93502000.0 127483000.0 True False 107143513.08148128 88298531.50513618 104282402.08604172 1.0 0.8241145820744767 0.9732964608574696 26.67496926493718 -10.126769641487996 5.808757735360563 1.0000008574369041 0.8987055214795893 0.3806980116250027 0.06090324698136237 6.763056556222843e-07 1.0165753152704741e-07 0.05896981442628469 0.019656438440728462 7.468447948406226e-11 10.126769641487996 -0.10129533595731488 LDTHPAMVTVLEMGAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDTHPAMVTVLEMGAAR 17 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 10675200.0 2231600.0 4709800.0 3733800.0 False True 2925649.2108451384 4007116.1986566074 3347462.1931386567 1.0 1.3696502587537018 1.144177566035563 21.48032536815367 -10.143454924170047 4.138955387980632 0.999932377623236 1.2569139122518938 0.6338492617263758 0.09204884154599641 12862115.716811113 15760781.788371004 6698.44862998227 0.031510767254507785 7.186957486125804e-11 10.143454924170047 0.2569815346286578 LDTHPAMVTVLEMGAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDTHPAMVTVLEMGAAR 17 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 6856200.0 2804100.0 0.0 4052100.0 False True 2715085.380386738 0.0 2990733.4496057006 1.0 0.0 1.1015246412544488 21.372566136018175 -10.666463842913204 4.268954941912219 1.016928763455796 0.5507623206314762 0.18151529347226392 0.4496955516967366 0.0731526674934038 0.005715460340153194 0.4396096816214363 0.14513861521530863 2.1554410868462107e-11 10.666463842913204 -0.46616644282431974 LDTHPAMVTVLEMGAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDTHPAMVTVLEMGAAR 17 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 11092100.0 2231600.0 3844400.0 5016100.0 False True 3056682.826722416 3674541.6962692565 3831400.489822295 1.0 1.2021337850775151 1.2534504582310833 21.543535429676563 -13.766691394747156 0.19509623004301868 3.7536176894087324e-08 1.2887783284970236 0.9994786438568761 0.00249810303611845 11.325012998832975 0.1387175769121144 4.322284777450743 0.03393148565330716 1.711230866452861e-14 13.766691394747156 1.2887782909608467 LDTHPAMVTVLEMGAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDTHPAMVTVLEMGAAR 17 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 5958900.0 2804100.0 1674200.0 1480600.0 False True 2331733.3926927396 1665180.7522973188 1790186.614479078 1.0 0.714138570694109 0.7677492718889826 21.15297141145245 -10.620303956541697 6.520471718534508 1.0008661567104504 0.7409439212915471 0.9688795072925848 0.0218864771133761 0.00027645819306811086 1.6098513385912674e-05 0.021258750315185735 0.007063830113937947 2.397154597303785e-11 10.620303956541697 -0.25992223541890336 LDTIFFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDTIFFAK 8 0 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 8450800.0 1742300.0 2321000.0 4387500.0 False True 2284172.1724572005 1974715.8471871414 3933523.5878718332 1.0 0.8645214537671383 1.7220784121716803 21.123239969144237 -6.866485284641032 1.152448891356353 0.9247798817428386 1.7690734754686066 0.9610518888786865 0.0742854120412546 0.14027365431726518 0.3503941982544377 0.050122366577484555 0.11800127886484038 1.3599242413149466e-07 6.866485284641032 0.844293593725768 LDTIFFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDTIFFAK 8 0 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 6476440.0 1785800.0 875040.0 3815600.0 False True 1729110.7564974974 1224448.035273318 2816179.894453619 1.0 0.708137423049505 1.6286868171233282 20.72159885168323 -6.821439368991055 1.3656001970618152 0.8429114144999076 1.6494161309521809 0.8876670375854168 0.1287376455729372 0.1916191763693168 0.7017598901786655 0.07407304274992205 0.17066732954802172 1.5085532020219768e-07 6.821439368991055 0.8065047164522733 LDTIFFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDTIFFAK 8 0 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 7968700.0 1742300.0 2863800.0 3362600.0 False True 2386475.3938871077 2737267.8466798193 2568423.1349208434 1.0 1.146991858240507 1.0762411971645673 21.186450030667128 -10.389325046921615 5.938173994824677 0.9999736103044532 1.1116165277025372 0.7684352095863715 0.028883836433440804 1.009363622837064e-05 1.0379830383228002e-06 0.027973263016740975 0.00932221812344124 4.0801389476107297e-11 10.389325046921615 0.11164291739808396 LDVGNAEVK(ub)LEEENR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDVGNAEVKLEEENR 15 1 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 35465900.0 9553900.0 10340000.0 15572000.0 True False 12525255.420099212 8797312.305004312 13960758.81717154 1.0 0.7023659007294423 1.1146087124713469 23.57833668795563 -6.712995958098058 1.7843563705413834 0.8175820108326488 1.1137341474490619 0.4793335838330953 0.12536481163315658 0.3691179491333511 2.2927003909086774 0.05586982124060696 0.14143131836948203 1.9364399859672503e-07 6.712995958098058 0.29615213661641304 LDVGNAEVK(ub)LEEENR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDVGNAEVKLEEENR 15 1 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 34929800.0 9916800.0 11891000.0 13122000.0 True False 9601996.61218187 16639138.310745798 9684954.548438106 1.0 1.7328831682398262 1.008639654814186 23.194902996302844 -10.63616223129267 5.897055690479528 0.997348308830012 1.3707614115270061 0.2589456513303089 0.29567117623555944 0.010368128561534448 0.0006396942575722432 0.287955952445146 0.09542746179282326 2.3112012765311816e-11 10.63616223129267 0.3734131026969941 LDVGNAEVK(ub)LEEENR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDVGNAEVKLEEENR 15 1 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 26863500.0 9916800.0 9527200.0 7419500.0 True False 8246258.588729125 9475875.082598863 8970883.146108013 1.0 1.149112046468002 1.0878731305333178 22.97530827173712 -10.11841658316509 4.665782462354899 0.999990871231324 1.118492588502505 0.8331081002087501 0.02500068274651304 2.3742558466560956e-06 4.486191133023483e-07 0.02420867175636073 0.008068935659194981 7.613483604620791e-11 10.11841658316509 0.11850171727118097 LDVGNAEVK(ub)LEEENR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDVGNAEVKLEEENR 15 1 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 76313000.0 13768000.0 29614000.0 32931000.0 True False 17822947.407853775 27965954.86720186 26937895.90059406 1.0 1.5690982095856107 1.5114164500493188 24.087232601468536 -10.172036133914181 4.970823137409826 0.9999586067273283 1.540257329818476 0.9915230471611282 0.02354847972516055 1.0803500957546933e-05 1.7994598288825815e-06 0.02280245936159708 0.007600239149834065 6.729206660054413e-11 10.172036133914181 0.5402987230911478 LDVGNFSWGSECCTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDVGNFSWGSECCTR 15 0 P62241 P62241 RPS8 40S ribosomal protein S8 0 103041000.0 28411000.0 35893000.0 38737000.0 False True 37247096.132515416 30537904.309818212 34728866.831542104 1.0 0.819873425868485 0.9323912583140949 25.150624618416604 -10.362670155064418 5.189235305784129 1.0000610521686761 0.8761323421035875 0.6177209688282792 0.04593521274264739 3.246147341395429e-05 3.986838218195311e-06 0.0444984771049565 0.014825526163060012 4.338402532429654e-11 10.362670155064418 -0.12392871006508865 LDVGNFSWGSECCTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDVGNFSWGSECCTR 15 0 P62241 P62241 RPS8 40S ribosomal protein S8 0 17389400.0 15209000.0 2180400.0 0.0 False True 14726198.619985685 3051045.090635791 0.0 1.0 0.20718483903205406 0.0 23.811881729352677 -9.399884472323603 0.45325404654829843 1.1879253384513755 1.4255989958449714e-23 0.9975288629084639 0.02142288360476564 0.8300361525002238 0.20769872914673718 0.3156163475107183 0.04671392670195132 3.9821308604656034e-10 9.399884472323603 -1.1879253384513755 LDVGNFSWGSECCTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDVGNFSWGSECCTR 15 0 P62241 P62241 RPS8 40S ribosomal protein S8 0 80778900.0 8268400.0 66031000.0 6479500.0 False True 12543767.301009677 54247252.14744225 5198823.9849342685 1.0 4.324637953310547 0.41445475351857036 23.58046736564008 -6.681473842110504 1.8967514162624646 3.100779451234386 0.4292178891646034 0.33080979404155664 1.408614415158932 0.43527582659888997 3.0289494229708995 0.595642875805969 1.5679502711611037 2.0822178150181593e-07 6.681473842110504 -2.671561562069783 LDVGNFSWGSECCTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDVGNFSWGSECCTR 15 0 P62241 P62241 RPS8 40S ribosomal protein S8 0 98401000.0 28411000.0 29247000.0 40743000.0 False True 38915314.47840596 27954770.833104506 31120342.528424438 1.0 0.7183488353567478 0.7996939751236769 25.213834679939495 -10.096759317648093 7.0727889700165925 1.0000000985252921 0.7590214052402124 0.9212676219789903 0.03320901424739296 5.158335971205766e-08 6.57117630840294e-09 0.03215450271770879 0.01071816326034312 8.002776392776344e-11 10.096759317648093 -0.2409786932850797 LDVGNFSWGSECCTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDVGNFSWGSECCTR 15 0 P62241 P62241 RPS8 40S ribosomal protein S8 0 32879200.0 8268400.0 15426000.0 9184800.0 False True 10703606.794530662 14567529.539456185 7513260.644006463 1.0 1.3609925905443307 0.7019372804170642 23.351593687732528 -6.75799340398637 1.6201157317097852 1.2102088019817498 0.6997733897250058 0.6826808884525134 0.15179354023852545 0.2863047351666091 1.4806518686713375 0.07394247753498319 0.17804275409095796 1.745848668463862e-07 6.75799340398637 -0.510435412256744 LDVPK(ub)QSSQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDVPKQSSQR 10 1 A0A1W2PNV4;O15143;C9JEY1;C9K057 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 1 3654830.0 897470.0 929660.0 1827700.0 True False 868980.3061002408 1300878.0861128534 1348970.5401753031 1.0 1.497016764339411 1.552360313237862 19.72896395571875 -11.698724903650822 0.3609401728846763 5.666409162988006e-10 1.5597713759137526 0.9995891917642695 0.0050340675515869356 4.459974018167446 0.18617906775137444 3.435866922908673 0.01590478708463458 2.001129048936021e-12 11.698724903650822 1.5597713753471116 LDVPK(ub)QSSQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDVPKQSSQR 10 1 A0A1W2PNV4;O15143;C9JEY1;C9K057 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 1 16081400.0 2633000.0 5203900.0 8244500.0 True False 3994453.498084095 4275223.386743726 6614970.961307277 1.0 1.070289937983832 1.6560390462625465 21.929566703381948 -6.929343309886264 0.7521562020432263 0.9908726658720108 1.7743065676215108 0.996407806053755 0.01762659278753567 0.09297977572143643 0.07935896244113781 0.01599653305288585 0.05319263496115761 1.1766754435726672e-07 6.929343309886264 0.7834339017495 LDVPK(ub)QSSQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDVPKQSSQR 10 1 A0A1W2PNV4;O15143;C9JEY1;C9K057 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 1 3493820.0 897470.0 1744100.0 852250.0 True False 746286.0696622633 1734704.187123255 1030451.5346412223 1.0 2.3244493735603386 1.3807728383668745 19.509369231153027 -10.122192152329559 4.606359758962589 0.9999235725998162 1.8526111059789179 0.5211678958569868 0.3852543323021723 268759543.58709353 33.592854848969594 219882.4988258968 0.13188280510279018 7.54758213204216e-11 10.122192152329559 0.8526875333791016 LDVTSVEDYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDVTSVEDYK 10 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 5495300.0 1058300.0 0.0 4437000.0 False True 1387441.5485917786 0.0 3977901.802709355 1.0 0.0 2.867077035963666 20.403995562889214 -6.8125017267591215 1.4041579179351245 0.4566126243810412 2.9200743330302084 0.8662204534051554 0.43459013706941146 0.2034097467455492 0.7899820340360657 0.2433398220594428 0.5622400911513363 1.5399204033086862e-07 6.8125017267591215 2.463461708649167 LDVTSVEDYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDVTSVEDYK 10 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 4935000.0 1058300.0 0.0 3876700.0 False True 1449582.1094821368 0.0 2961103.3031427003 1.0 0.0 2.0427289242694604 20.467205624412106 -6.773605853716403 1.5607416488148298 0.42906067782618523 2.0557885052894838 0.7441037709086531 0.4218895074649881 0.2606526643995371 1.2535304926500446 0.21300903585970635 0.5053726983889627 1.6842018741113816e-07 6.773605853716403 1.6267278274632986 LDVTSVEDYK(ub)ALQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDVTSVEDYKALQK 14 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 8775500.0 2249400.0 3606400.0 2919700.0 True False 2948985.1832205886 3068339.1776370984 2617597.4517400335 1.0 1.0404729040673453 0.8876265186525466 21.491787143114845 -6.836282784278892 1.2993941353986764 1.0215529641154713 0.882953783032301 0.9178866474313301 0.018528508097702154 0.1731948740500905 0.5696154187561299 0.011186970360021278 0.025754743764897156 1.4578646846332166e-07 6.836282784278892 -0.13859918108317026 LDVTSVEDYK(ub)ALQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDVTSVEDYKALQK 14 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 15607100.0 4559300.0 4843300.0 6204500.0 True False 4414567.517134644 6777254.947475831 4579355.3189897975 1.0 1.5352024680040985 1.037328187011649 22.073840677311846 -10.538436372410217 3.240436279166448 0.9908687051060292 1.2862653273985354 0.3059388229469485 0.20325632490866977 148792741.9701405 204288727.86716253 12125222.78054324 0.07438420325283136 2.894433843541781e-11 10.538436372410217 0.2953966222925062 LDVTSVEDYK(ub)ALQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDVTSVEDYKALQK 14 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 8788700.0 2249400.0 2586700.0 3952600.0 True False 3081063.9677493344 2472411.0409269794 3019077.286352267 1.0 0.8024536545838203 0.979881403941656 21.554997204637736 -10.324545713607758 6.853135518754328 1.0000025572826308 0.8911675292829876 0.3340719092481398 0.07243457535618718 2.8302873345379547e-06 2.7893079523080626e-07 0.07013612403161731 0.023378158670343256 4.736464497755347e-11 10.324545713607758 -0.10883502799964317 LDVTSVEDYK(ub)ALQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDVTSVEDYKALQK 14 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 13502900.0 4559300.0 5559300.0 3384300.0 True False 3791259.961236763 5529350.947465349 4091941.482764784 1.0 1.4584467971068902 1.0793091279949936 21.854245952746123 -10.138228205721969 5.792308810862169 0.9999972590137921 1.2688779625509548 0.4014080919859846 0.1547823052654308 5.478788827632534e-06 8.148664901712909e-07 0.14986884996368466 0.049955774215043935 7.273974835658918e-11 10.138228205721969 0.26888070353716265 LDVTSVEDYK(ub)ALQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDVTSVEDYKALQK 14 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 34085900.0 7721900.0 10422000.0 15942000.0 True False 9996151.771405147 9842006.538325699 13040719.57873344 1.0 0.9845795425475238 1.304573987765726 23.252941375329755 -6.895577273158247 0.988773436961493 0.9850338144460284 1.3353058829662514 0.9842355122752106 0.018500370880018237 0.11473560377224891 0.19633285245173543 0.014140998746407223 0.03604152844958476 1.2718114390587e-07 6.895577273158247 0.35027206852022297 LDYDEDASAMLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDYDEDASAMLK 12 0 P50502;Q8NFI4;H7C3I1 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 0 19232200.0 3077200.0 8475600.0 7679400.0 False True 4034238.9996471866 7211073.5176300425 6884809.354006365 1.0 1.7874680995004721 1.706594317939139 21.94386512511243 -10.208682785459999 4.446779968345056 0.9997739527729104 1.7470312087332989 0.9912863837694176 0.03301658311191923 23229701.077160187 22.18202576081295 53805.97208797868 0.011302454581977485 6.184679725396362e-11 10.208682785459999 0.7472572559603885 LDYDEDASAMLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDYDEDASAMLK 12 0 P50502;Q8NFI4;H7C3I1 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 0 12736000.0 3077200.0 4679400.0 4979400.0 False True 4214923.998203182 4472648.635293508 3803368.2739620726 1.0 1.0611457376693374 0.9023574981621127 22.007075186635323 -6.802297644573906 1.4463945978083106 1.0336391520399735 0.9000361393527566 0.8388295489842176 0.026252823534344934 0.2174927400841603 0.8980234714303171 0.01427701708245526 0.03315948455690252 1.5765304211484428e-07 6.802297644573906 -0.13360301268721686 LDYFLLSHSLLPALCDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDYFLLSHSLLPALCDSK 18 0 P27695 P27695 APEX1 DNA-(apurinic or apyrimidinic site) lyase;DNA-(apurinic or apyrimidinic site) lyase, mitochondrial 0 4802070.0 1167900.0 833170.0 2801000.0 False True 1599704.1913107713 796357.7944752519 2139461.488405784 1.0 0.4978156579203118 1.3374106913183397 20.60937372369693 -6.744718067980731 1.6695097013546494 0.7028459336074026 1.3384188541465956 0.6258993701552868 0.210988389750977 0.3093431016543022 1.694681066967572 0.0999091043438844 0.2439015619709012 1.8000390717211536e-07 6.744718067980731 0.635572920539193 LDYILGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDYILGLK 8 0 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 0 54374000.0 18899000.0 13435000.0 22040000.0 False True 24776772.01817632 11430550.36921982 19759512.222608604 1.0 0.4613413870392128 0.7975014746922222 24.562484905898344 -10.640594762156551 5.136842184499181 1.0052804667422117 0.6294214308657332 0.6183706167350707 0.1372367811065276 0.008384769198816111 0.0005866499354240446 0.1342475895320768 0.04429298064272393 2.2877324786221258e-11 10.640594762156551 -0.3758590358764785 LDYILGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDYILGLK 8 0 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 0 44310700.0 20381000.0 5856700.0 18073000.0 False True 19734016.310995344 8195310.852287015 13339139.121621842 1.0 0.4152885415282025 0.6759464931722783 24.23418127066733 -10.392756741850452 5.986011401226067 1.00010530682367 0.5456175173502518 0.8020478074123505 0.10641316315450708 0.0001495860588572826 1.5174551567630467e-05 0.1030577620317082 0.034344700726221436 4.0480256727043457e-11 10.392756741850452 -0.4544877894734183 LDYILGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDYILGLK 8 0 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 0 48990000.0 18899000.0 14115000.0 15976000.0 False True 25886471.02627126 13491352.627936875 12202797.836048113 1.0 0.5211738832320937 0.4713967316620302 24.625694967421236 -13.999999999999998 0.3198516393591065 5.905275926923445 0.4614980802436705 0.999693408481183 0.004172944600622308 18.001865372042673 0.1803544183244735 59.086265495774164 0.01658227600265042 1.0000000000000041e-14 13.999999999999998 -5.443777846679775 LDYILGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDYILGLK 8 0 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 0 33033300.0 20381000.0 6711200.0 5941100.0 False True 16947704.53138999 6675045.433531093 7183356.541457293 1.0 0.39386132919462874 0.42385424693665813 24.014586546101608 -10.731200042895155 6.853826265526575 1.0084993118852676 0.40885778806564343 0.9980730201908566 0.012244557394206764 0.0015845664469300697 6.214496505208266e-05 0.01181346698562812 0.003951913905786975 1.8569489180800814e-11 10.731200042895155 -0.5996415238196242 LDYILGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDYILGLK 8 0 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 0 14163900.0 4410500.0 6380700.0 3372700.0 False True 5709479.193952573 6025608.435913918 2758903.2068243828 1.0 1.0553691906428497 0.4832145127609164 22.444927721467504 -6.883142304616004 1.0620748517386276 1.0359834525514406 0.44013398146482463 0.9761347717471637 0.03980414481807563 0.12488495884509636 0.25575142242754023 0.028782482866870435 0.07019646426245373 1.3087530156124236e-07 6.883142304616004 -0.595849471086616 down LDYITAEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDYITAEIK 9 0 O15212 O15212 PFDN6 Prefoldin subunit 6 0 10420500.0 2543700.0 3609200.0 4267600.0 False True 3334815.3332258407 3070721.428551409 3826029.6897098185 1.0 0.9208070377861169 1.147298817895507 21.669175443113147 -6.812228975732875 1.405023931834318 0.9569528934397101 1.1514711891685767 0.86560074613351 0.03440514257356375 0.2037729225932089 0.7923808251766451 0.019251628290415546 0.044492206702401504 1.540887827042917e-07 6.812228975732875 0.19451829572886659 LDYITAEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDYITAEIK 9 0 O15212 O15212 PFDN6 Prefoldin subunit 6 0 6475600.0 1358600.0 1178000.0 3939000.0 False True 1315471.98666004 1648381.5431888453 2907257.732532972 1.0 1.2530723268186477 2.210049139787802 20.32714909556499 -6.946166679330667 0.599453000214754 0.9892079723767605 2.522855526566653 0.9988650942609067 0.0175555872665198 0.08506250573594316 0.04262116721854812 0.0180277597607561 0.08040759358928254 1.131965838904657e-07 6.946166679330667 1.5336475541898924 up LDYITAEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDYITAEIK 9 0 O15212 O15212 PFDN6 Prefoldin subunit 6 0 6650100.0 2543700.0 2039600.0 2066800.0 False True 3484174.6309077875 1949483.7279447427 1578664.4070821407 1.0 0.5595252633582297 0.4530956608999894 21.73238550463604 -13.999999999999998 0.19950857785437015 3.4439772090296596 0.3836397862102573 0.9994869151265275 0.005362681382449992 12.52126675596647 0.1416323302171592 11.939091777970331 0.06801816965740504 1.0000000000000041e-14 13.999999999999998 -3.0603374228194022 LDYITAEIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDYITAEIK 9 0 O15212 O15212 PFDN6 Prefoldin subunit 6 0 3440560.0 1358600.0 1210300.0 871660.0 False True 1129736.0961849978 1203779.8736742595 1053920.0758995232 1.0 1.0655407734065503 0.9328905037720778 20.107554370999267 -6.772367455841183 1.5654845329990281 1.0374787431349817 0.9320783616872005 0.7395020233824203 0.027640430622817683 0.26261787553336946 1.2705152724122732 0.013914572069591267 0.033049786645296765 1.6890112572811888e-07 6.772367455841183 -0.10540038144778119 LDYLDLYLIHWPTGFKPGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDYLDLYLIHWPTGFKPGK 19 1 P15121;E9PCX2 P15121 AKR1B1 Aldose reductase 0 16121100.0 7722900.0 5841700.0 2556500.0 False True 10124796.688669993 4970141.130768256 2291977.903679622 1.0 0.49088799346756473 0.2263727336119674 23.271389602412007 -9.173972737429475 0.21779974189830728 1.3994822909307691 6.7433296737862735e-18 0.9994137573406885 0.007773423628425313 0.6078626313369663 0.07724566815900595 0.30205392530742825 0.1300443324112728 6.699266623331492e-10 9.173972737429475 -1.3994822909307691 LDYLDLYLIHWPTGFKPGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDYLDLYLIHWPTGFKPGK 19 1 P15121;E9PCX2 P15121 AKR1B1 Aldose reductase 0 288818000.0 113492000.0 57671000.0 117655000.0 False True 109889258.58237992 80699331.05029206 86837625.925658 1.0 0.7343696016457764 0.7902285177450628 26.71147513221693 -10.750722863951585 6.925529415297558 1.004463286451387 0.762299059695427 0.9602296324730991 0.022804307004698026 0.001593002409656258 5.7338384261630794e-05 0.022381669042275294 0.007360058437583048 1.7753220045515133e-11 10.750722863951585 -0.24216422675595994 LDYLDLYLIHWPTGFKPGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LDYLDLYLIHWPTGFKPGK 19 1 P15121;E9PCX2 P15121 AKR1B1 Aldose reductase 0 187618000.0 62053000.0 57206000.0 68359000.0 False True 94138937.68196434 46997142.347481996 54847813.68718596 1.0 0.49923170480482243 0.5826262228758293 26.48828823712813 -10.7756995027109 7.09206720135638 1.0117794684398953 0.5409289638403258 0.9758476975685927 0.0340456694365463 0.006271699918119698 0.00019835452469741034 0.03260397198304246 0.010988192561518884 1.6761022045053123e-11 10.7756995027109 -0.47085050459956945 LDYLDLYLIHWPTGFKPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LDYLDLYLIHWPTGFKPGK 19 1 P15121;E9PCX2 P15121 AKR1B1 Aldose reductase 0 21695700.0 7722900.0 4013900.0 9958900.0 False True 10578264.833525088 3836552.62580771 7606812.929983702 1.0 0.36268260307198436 0.719098363455211 23.3345996639349 -10.688755447560863 6.9067266368200935 1.0032526344262929 0.5408904832637341 0.6887032404748142 0.14550612487083014 0.007319728395552176 0.0003298554301530997 0.14150481400389844 0.046961899866325166 2.047597319940434e-11 10.688755447560863 -0.46236215116255874 LDYLDLYLIHWPTGFKPGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDYLDLYLIHWPTGFKPGK 19 1 P15121;E9PCX2 P15121 AKR1B1 Aldose reductase 0 211465800.0 113492000.0 48729000.0 49244800.0 False True 94373626.54808469 48466487.20505078 59541659.99777074 1.0 0.5135596562070911 0.630914188376913 26.491880407651205 -9.975208585356564 7.055127378555053 1.0000000251865877 0.5722369222920319 0.9465674411077887 0.04790978713651827 1.898709916962011e-08 2.7433626104961266e-09 0.046388454689977834 0.015462817308339498 1.0587451030893836e-10 9.975208585356564 -0.42776310289455577 LDYLDLYLIHWPTGFKPGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LDYLDLYLIHWPTGFKPGK 19 1 P15121;E9PCX2 P15121 AKR1B1 Aldose reductase 0 159956000.0 62053000.0 49063000.0 48840000.0 False True 80328831.74749787 46332600.92015677 39951621.14071898 1.0 0.5767866893146988 0.49735095446552935 26.25941455922058 -13.999999999999998 0.23525015806837518 3.7381791142032506 0.46060865747682306 0.9995173956873896 0.0048467271489419286 13.460465473459521 0.15353806073917453 17.267226921391625 0.03992883604045757 1.0000000000000041e-14 13.999999999999998 -3.2775704567264277 LDYLGVSYGLTPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LDYLGVSYGLTPR 13 0 A0A087WV29;Q9H0A0-2;Q9H0A0 A0A087WV29 NAT10 N-acetyltransferase 10 0 8796400.0 3438500.0 0.0 5357900.0 False True 4507906.798481364 0.0 4803515.9046059195 1.0 0.0 1.065575691632343 22.104026257248076 -10.556783640702426 5.050459596186336 1.0026981607299061 0.5327878458161651 0.20403039692975677 0.4350194544687759 0.013279450627382769 0.0011653717747582603 0.4232191454154025 0.1404019252028137 2.774702077261899e-11 10.556783640702426 -0.469910314913741 LDYLGVSYGLTPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LDYLGVSYGLTPR 13 0 A0A087WV29;Q9H0A0-2;Q9H0A0 A0A087WV29 NAT10 N-acetyltransferase 10 0 11479000.0 3483400.0 1779000.0 6216600.0 False True 3372821.37371676 2489363.977362442 4588285.965997588 1.0 0.7380657620238064 1.3603702828001882 21.685524483862565 -6.792407229846893 1.4871500636672188 0.8540608722059622 1.3673922921381356 0.8088886889439196 0.11152547623811872 0.23178749246720162 1.0127061211793944 0.05902566153233796 0.1379283030276453 1.6128455123630416e-07 6.792407229846893 0.5133314199321735 LDYLGVSYGLTPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LDYLGVSYGLTPR 13 0 A0A087WV29;Q9H0A0-2;Q9H0A0 A0A087WV29 NAT10 N-acetyltransferase 10 0 8449700.0 3483400.0 1927000.0 3039300.0 False True 2896601.44078524 1916618.868520446 3674803.577864559 1.0 0.6616784903624399 1.268660412206505 21.46592975929684 -6.755451582407252 1.6298235544926023 0.802374610205601 1.2703756848178527 0.6720411344168521 0.1422201405384435 0.2906236128080293 1.5204380157764414 0.06888949526557123 0.16628907633379317 1.756096662824302e-07 6.755451582407252 0.4680010746122517 LEAAAQVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEAAAQVR 8 0 E9PLK3;P55786;P55786-2;A6NEC2;E9PP11;E9PJY4;E9PPD4;A6NEC2-3;E9PJF9;E9PPZ2 E9PLK3 NPEPPS;NPEPPSL1 Puromycin-sensitive aminopeptidase;Puromycin-sensitive aminopeptidase-like protein 0 5158400.0 1390200.0 1982900.0 1785300.0 False True 1822565.6627159526 1687059.0492836637 1600574.2818068543 1.0 0.9256506274619706 0.8781984180595771 20.797539361691577 LEAAAQVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEAAAQVR 8 0 E9PLK3;P55786;P55786-2;A6NEC2;E9PP11;E9PJY4;E9PPD4;A6NEC2-3;E9PJF9;E9PPZ2 E9PLK3 NPEPPS;NPEPPSL1 Puromycin-sensitive aminopeptidase;Puromycin-sensitive aminopeptidase-like protein 0 3808150.0 1390200.0 956450.0 1461500.0 False True 1904194.5087423874 914190.8764428076 1116323.8005373254 1.0 0.48009322169854324 0.5862446275378633 20.860749423214468 -9.98711658175013 6.064597102963116 1.0000003360701288 0.5331689246182467 0.9626689487839162 0.043336129964407576 1.9689606091061052e-07 3.288858768614048e-08 0.04196005742144625 0.013986675803411064 1.0301095613310564e-10 9.98711658175013 -0.4668314114518821 LEAALGEAK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEAALGEAKK 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 13532500.0 5774700.0 4681000.0 3076800.0 True False 5591385.309410971 6550147.711092524 2270893.777978537 1.0 1.1714713525587017 0.4061415288544596 22.41477433565115 -6.847893476143222 1.2452942881391964 1.0913631137203614 0.3767822216317055 0.9371663900402271 0.0821991960123607 0.15979615141971917 0.47793566588126285 0.05167888476832589 0.11943245963838672 1.4194056311556493e-07 6.847893476143222 -0.7145808920886559 down LEAALGEAK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEAALGEAKK 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 25142200.0 11261000.0 8118300.0 5762900.0 True False 17083760.289375223 6669525.936432581 4623860.289031201 1.0 0.3904015171987932 0.27065822808968376 24.0261222242841 -13.999999999999961 0.22880865990907961 4.82711951032074 0.2117741259926549 0.9995081902071792 0.0070822634378303944 13.254409298559278 0.15146528137666881 23.0299326560478 0.06262123698744507 1.00000000000009e-14 13.999999999999961 -4.615345384328085 LEAALGEAK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEAALGEAKK 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 22843100.0 11261000.0 9700800.0 1881300.0 True False 14577586.48749575 9160941.952311462 1538922.7037681094 1.0 0.628426520409909 0.10556772927316567 23.79724854637655 -7.5325974849743 0.5168190476751947 1.0121258498508965 1.3289083398107326e-22 0.9963649034591564 0.022120286745407277 0.11665980802552094 0.07834658652654974 0.02417124689810603 0.07051710628677392 2.9336109298838568e-08 7.5325974849743 -1.0121258498508965 down LEAALGEAKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEAALGEAKK 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 17243300.0 6390800.0 8218400.0 2634100.0 True False 8378400.688595243 6992246.755072299 2361548.600071384 1.0 0.8345562613865211 0.2818615017166637 22.998243450619352 -6.949010976514468 0.5695992837938371 1.006897335196143 0.08266735543210371 0.9991213576045486 0.009101805621856413 0.08388536202866725 0.037625011031919356 0.009647218131337516 0.04604580382426096 1.1245765506567379e-07 6.949010976514468 -0.9242299797640393 down LEAALGEAKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEAALGEAKK 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 15625000.0 6347700.0 5873100.0 3404200.0 True False 6146195.738055315 8218259.457811896 2512537.8961890717 1.0 1.337129471312964 0.4087956198062853 22.55126228253312 -6.808435807610755 1.4209848583485405 1.1840757577097298 0.3931114790178383 0.8557354237249577 0.14573494158690736 0.2089388167954663 0.8317787762628328 0.08064765083777391 0.1867001122189843 1.5544050279726898e-07 6.808435807610755 -0.7909642786918916 down LEAALGEAKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEAALGEAKK 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 34620000.0 16373000.0 11759000.0 6488000.0 True False 24839038.026635338 9660514.576513657 5205643.956208574 1.0 0.38892466633186507 0.20957510313509203 24.566105965745916 -13.999999999999996 0.1718531498881299 4.096905656152556 0.05444946586034178 0.9995102651655643 0.007487755942761443 12.110077721045203 0.13130993969690286 12.504845786490002 0.1437906070857257 1.0000000000000082e-14 13.999999999999996 -4.0424561902922145 LEAALGEAKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEAALGEAKK 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 12648700.0 6390800.0 4255100.0 2002800.0 True False 8753651.464876166 4067095.6122659766 1529779.888960763 1.0 0.464617037653956 0.1747590585596161 23.061453512142243 -8.80633745166685 0.26775028851059457 1.257730794811109 6.1313979341665674e-24 0.9990392398500189 0.010595634845245588 0.33151040823161776 0.08379111118654016 0.18794890349258703 0.10668766018254948 1.561933531200397e-09 8.80633745166685 -1.257730794811109 LEAALGEAKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEAALGEAKK 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 17435500.0 6347700.0 9478500.0 1609300.0 True False 5278393.800790168 9427437.439165067 1945797.1894375104 1.0 1.786042837075512 0.3686343351544228 22.331667557967396 -6.756175410019738 1.6266463305815226 1.4587610155694994 0.3643839845126994 0.6751541952613802 0.33045955187935516 0.2894397206515347 1.5084531276581545 0.16035146113816673 0.3868529343179339 1.753172258689686e-07 6.756175410019738 -1.0943770310568 LEAALGEAKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEAALGEAKK 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 32728300.0 16373000.0 12555000.0 3800300.0 True False 21195171.260080628 11856303.213268004 3108684.394370891 1.0 0.559386997527988 0.1466694633520534 24.337232287838365 -7.805549795498804 0.3964495072813737 1.0521253496633964 8.113927125095956e-18 0.9980443510497367 0.015408643895536157 0.11309113230130724 0.07130924610905606 0.03441615514750239 0.07913223995965266 1.5647688950828138e-08 7.805549795498804 -1.0521253496633964 down LEAALVK(ub)RPNPDILDHER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEAALVKRPNPDILDHER 18 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 16618700.0 5975400.0 7804200.0 2839100.0 True False 7833807.26585592 6639843.780533344 2545337.1665702397 1.0 0.8475883507465736 0.32491700142588803 22.901282203610492 -6.948412135473889 0.5760177053814104 1.0063454387199355 0.14048424636023557 0.9990706688418189 0.008812854976890647 0.0841298027137853 0.03865081978615731 0.009273844302052242 0.043615243613016476 1.1261282791093238e-07 6.948412135473889 -0.8658611923596999 down LEAALVK(ub)RPNPDILDHER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEAALVKRPNPDILDHER 18 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 35539400.0 8641200.0 13213000.0 13685200.0 True False 8366889.835953743 18489019.804884724 10100635.572800277 1.0 2.209784061627621 1.2072150788213292 22.996260009052463 -6.599819221316042 2.1909285319491896 1.8136732877227713 1.2104210979237293 0.02015599768474019 0.5229228872590783 0.6412012461835522 5.816350778940052 0.19811914326617153 0.5818458751504373 2.512932242741122e-07 6.599819221316042 -0.6032521897990419 LEAALVK(ub)RPNPDILDHER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEAALVKRPNPDILDHER 18 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 38891400.0 13552600.0 18856600.0 6482200.0 True False 20560285.02777609 15491492.402711727 5200990.3287508115 1.0 0.7534668114660553 0.25296294879786396 24.293356929001536 -7.0189643387828795 0.45526852448388344 1.01558223500012 5.252212502189795e-15 0.999741707163835 0.004994951055188321 0.07394597105377053 0.02242939411081231 0.006674321540514855 0.0382235625798369 9.572726725861686e-08 7.0189643387828795 -1.0155822350001147 down LEAALVK(ub)RPNPDILDHER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEAALVKRPNPDILDHER 18 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 21073200.0 5975400.0 10036000.0 5061800.0 True False 8184666.859113263 9592576.335386084 3866307.0910433372 1.0 1.172017933106853 0.4723841736745065 22.964492265133384 -6.84168508406133 1.274632676666152 1.0914960799356777 0.4486067109310535 0.9272992556121353 0.08026044168098675 0.16684036741533217 0.5258272076696227 0.04936173203957812 0.11377084249935668 1.439842259305809e-07 6.84168508406133 -0.6428893690046242 down LEAALVK(ub)RPNPDILDHER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEAALVKRPNPDILDHER 18 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 24024100.0 8641200.0 11168900.0 4214000.0 True False 7185540.670067583 11108730.918846935 5095127.916665428 1.0 1.5459840016106197 0.7090806594262178 22.77666528448674 -6.730619029040455 1.7206517233322207 1.3283300502836257 0.709489148947198 0.5623271054941987 0.22950694249783649 0.3350525929674796 1.943583316060625 0.10568238342954711 0.2620922526789112 1.859434869707384e-07 6.730619029040455 -0.6188409013364278 LEADQSPK(ub)NSAILQNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEADQSPKNSAILQNR 16 1 P49454 P49454 CENPF Centromere protein F 1 3787800.0 1106500.0 1333500.0 1347800.0 True False 1450632.2153612417 1134546.9979422875 1208342.5850105183 1.0 0.7821051993249429 0.8329765272099741 20.46825036279397 -10.809227678165087 7.1049718287179475 1.0084899777910827 0.8075408632676808 0.950209144989335 0.0207681326426906 0.002861240949249971 7.682575899205262e-05 0.020600098751521804 0.0067028859880806126 1.5515733869201146e-11 10.809227678165087 -0.20094911452340192 LEADQSPK(ub)NSAILQNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEADQSPKNSAILQNR 16 1 P49454 P49454 CENPF Centromere protein F 1 7464700.0 1172600.0 1347100.0 4945000.0 True False 1135376.4548487875 1885004.0550336947 3649756.153179878 1.0 1.6602458567671676 3.214577982124847 20.1147392981131 -6.956736912852545 0.47921994254015665 0.9624163580093853 3.9771255120134374 0.9996293529222919 0.01787245913448652 0.08088813655665601 0.025600440567443365 0.021881065034160804 0.12822275701362404 1.1047476518717486e-07 6.956736912852545 3.014709154004052 LEADQSPK(ub)NSAILQNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEADQSPKNSAILQNR 16 1 P49454 P49454 CENPF Centromere protein F 1 31172100.0 2603200.0 9753900.0 18815000.0 True False 3949244.7194122663 8013240.33743146 15096207.003092565 1.0 2.029056416292178 3.822555469628939 21.913145338121048 -6.962644154374969 0.396410973315738 0.8974203534745817 5.0193009982918975 0.9998560476083049 0.013993350280108483 0.07876974761042295 0.017737755784972106 0.023093795668436896 0.1504720009221398 1.0898226899872017e-07 6.962644154374969 4.121880644817316 LEADQSPK(ub)NSAILQNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEADQSPKNSAILQNR 16 1 P49454 P49454 CENPF Centromere protein F 1 3699300.0 1106500.0 885200.0 1707600.0 True False 1515602.9520381587 846088.93703505 1304300.0491259233 1.0 0.5582523680738699 0.8605816235524756 20.53146042431686 -10.197037476927898 5.417336351221571 1.000012982315058 0.7094169958131308 0.551918993830226 0.12342540170650187 1.9353692228778167e-05 2.8686561867642556e-06 0.11951146708528829 0.039835377108998656 6.3527610908699e-11 10.197037476927898 -0.2905959865019273 LEADQSPK(ub)NSAILQNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEADQSPKNSAILQNR 16 1 P49454 P49454 CENPF Centromere protein F 1 5931500.0 1172600.0 2081300.0 2677600.0 True False 975068.854987876 2070087.623794297 3237473.7801764053 1.0 2.1230168651218344 3.3202514505672114 19.895144573547377 -6.970312473882175 0.2506093380349692 0.622890545542612 4.855470425172661 0.9999847186505426 0.0037035123743167976 0.07620144197459408 0.008666553969673581 0.02659290192624756 0.11462968242334105 1.0707486268426324e-07 6.970312473882175 4.232579879630049 LEADQSPK(ub)NSAILQNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEADQSPKNSAILQNR 16 1 P49454 P49454 CENPF Centromere protein F 1 28665600.0 2603200.0 9764400.0 16298000.0 True False 3369893.7167435307 9221002.556402564 13331931.23160192 1.0 2.7362888362287 3.9561874504710266 21.684271660213497 -8.04980927797373 0.21535627018316458 4.4283703565550726e-15 5.358885849137218 0.999756721908574 0.01891931063971836 0.09976886581010527 0.04109232995162279 0.36250040848302284 0.46404891862962844 8.916424202301527e-09 8.04980927797373 5.358885849137214 LEAEDYLK(ub)QQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEAEDYLKQQR 11 1 Q99570 Q99570 PIK3R4 Phosphoinositide 3-kinase regulatory subunit 4 1 18983100.0 1724000.0 2498100.0 14761000.0 True False 2231751.9851205624 2359078.538993612 12074649.46065012 1.0 1.0570522865990286 5.410390375433151 21.08974527851743 -6.9097575827973055 0.8973840663059189 0.8641765219660535 5.970078823720483 0.9908297691421304 0.19782009290785765 0.10457853406958209 0.13963838446943247 0.16176409889233387 0.44579567538387177 1.2309556816025575e-07 6.9097575827973055 5.10590230175443 up LEAFGQGESVLK(ub)EPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEAFGQGESVLKEPK 15 1 A0A3B3IUD2;Q9BUK6-7;Q9BUK6-3;Q9BUK6-2;Q9BUK6;Q9BUK6-5 A0A3B3IUD2 MSTO1 Protein misato homolog 1 1 10726000.0 1558000.0 2434000.0 6734000.0 True False 1508542.1428060827 3405908.893142316 4970163.384330302 1.0 2.2577485881878556 3.2946798390962795 20.52472356966566 -7.057259334995235 0.16547798126300817 1.6834652714694756e-12 5.493352343117869 0.9999979947795397 0.0013285952146959656 0.07324249749295869 0.005350578184462531 0.04899418390827274 0.12321804618163006 8.764772844173039e-08 7.057259334995235 5.493352343116186 LEAFGQGESVLK(ub)EPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEAFGQGESVLKEPK 15 1 A0A3B3IUD2;Q9BUK6-7;Q9BUK6-3;Q9BUK6-2;Q9BUK6;Q9BUK6-5 A0A3B3IUD2 MSTO1 Protein misato homolog 1 1 42151600.0 5330400.0 8188200.0 28633000.0 True False 8086606.504438827 6726951.735301401 22973674.999710266 1.0 0.8318633695863529 2.8409537408676635 22.947102980716657 -6.886581793346174 1.042433070397977 0.8830376265019505 3.0025852291645005 0.9786171373750034 0.1330764649774036 0.12195862656034454 0.23842068606339906 0.09768290979525093 0.24070404025264783 1.2984289996943983e-07 6.886581793346174 2.11954760266255 up LEAFGQGESVLK(ub)EPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEAFGQGESVLKEPK 15 1 A0A3B3IUD2;Q9BUK6-7;Q9BUK6-3;Q9BUK6-2;Q9BUK6;Q9BUK6-5 A0A3B3IUD2 MSTO1 Protein misato homolog 1 1 10151300.0 1558000.0 2435800.0 6157500.0 True False 1295546.0311027735 2422677.8619315536 7445004.780936731 1.0 1.8700052362241126 5.746615405551832 20.305128845099937 -6.942404236610874 0.636803134299169 0.9576405997386513 6.870358415686765 0.9984621648926716 0.08091334593174428 0.08668671226981411 0.04974181032954753 0.08027980954126072 0.33027993511902637 1.1418150509087576e-07 6.942404236610874 5.912717815948114 LEAFGQGESVLK(ub)EPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEAFGQGESVLKEPK 15 1 A0A3B3IUD2;Q9BUK6-7;Q9BUK6-3;Q9BUK6-2;Q9BUK6;Q9BUK6-5 A0A3B3IUD2 MSTO1 Protein misato homolog 1 1 30876100.0 5330400.0 6076700.0 19469000.0 True False 6900307.877892487 5738526.303151392 15925841.768809516 1.0 0.8316333712495262 2.307990027493329 22.718229302809107 -6.878531860412528 1.0878989642351047 0.8975308902057617 2.4097397056277816 0.9724842385192436 0.10945783399287476 0.12894113878262325 0.28018125651583653 0.07760182850118758 0.18698938755390485 1.3227206679282743e-07 6.878531860412528 1.51220881542202 up LEAIEDDSVK(ub)ETDSSSASAATPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEAIEDDSVKETDSSSASAATPSK 24 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 36043600.0 12045000.0 7880600.0 16118000.0 True False 15791111.64394593 6704845.198338206 14450263.97477337 1.0 0.42459614937297596 0.9150884561261005 23.912609400118793 -10.224659976113879 7.936146631764999 1.0000002320113912 0.6698423027495427 0.3766019851227357 0.20024264571763978 8.21973437535167e-07 8.045360796503822e-08 0.1938842438004049 0.06462803600541094 5.961286902466524e-11 10.224659976113879 -0.3301579292618485 LEAIEDDSVK(ub)ETDSSSASAATPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEAIEDDSVKETDSSSASAATPSK 24 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 31608700.0 8053700.0 10448000.0 13107000.0 True False 7798039.701872506 14619940.88560023 9673883.498428456 1.0 1.8748225765110702 1.2405532503387373 22.89468006921858 -9.898966315858654 5.613512500250211 0.9999996321052977 1.5576879134263155 0.5075828575691054 0.25893936810850365 1.1922413601016597e-06 2.3360214450600025e-07 0.25071712946533237 0.08357232169608456 1.2619254064889886e-10 9.898966315858654 0.5576882813210178 LEAIEDDSVK(ub)ETDSSSASAATPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEAIEDDSVKETDSSSASAATPSK 24 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 58701000.0 17087000.0 26139000.0 15475000.0 True False 25922228.227027312 21474291.22506082 12416359.467066547 1.0 0.8284122428438102 0.4789850377955113 24.627686399174642 -6.95969049626426 0.4397785542058148 1.012522919721648 0.281255818483827 0.9997585347527411 0.003368796260660227 0.07981192612483154 0.021541653958629836 0.004605723510412837 0.02895342452391589 1.0972598893631716e-07 6.95969049626426 -0.7312671012378211 down LEAIEDDSVK(ub)ETDSSSASAATPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEAIEDDSVKETDSSSASAATPSK 24 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 30304600.0 12045000.0 8301800.0 9957800.0 True False 16498362.0038858 7934999.025618599 7605972.727328483 1.0 0.4809567776334219 0.46101381007018005 23.975819461641684 LEAIEDDSVK(ub)ETDSSSASAATPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEAIEDDSVKETDSSSASAATPSK 24 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 32827500.0 8053700.0 16056000.0 8717800.0 True False 6697008.389404634 15969503.141133526 10540651.673447046 1.0 2.3845726647735646 1.573934368982344 22.675085344652857 -10.039625698876907 5.464993609170773 0.9999944734306345 1.9792535168787655 0.6605215512065654 0.33094169844415794 2.228438066807847e-05 3.9160149437981456e-06 0.32043472972966786 0.1068109738862384 9.127972040073627e-11 10.039625698876907 0.979259043448131 LEAIEDDSVK(ub)ETDSSSASAATPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEAIEDDSVKETDSSSASAATPSK 24 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 68327000.0 17087000.0 36415000.0 14825000.0 True False 22119458.33512477 34388473.238642395 12127002.117345588 1.0 1.5546706758200741 0.5482504107294716 24.39881272126709 -6.757082535978863 1.6234607005283794 1.323347990350336 0.5450948407172678 0.6789524858759342 0.23320833312119693 0.2878410169367486 1.4945142749975977 0.1133780096870278 0.2732550016586986 1.7495141686584644e-07 6.757082535978863 -0.7782531496330682 LEALITQTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEALITQTR 9 0 Q9UHB9-4;Q9UHB9 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 0 8103900.0 1804500.0 3470600.0 2828800.0 False True 2365716.9748028563 2952800.0082928445 2536102.911765662 1.0 1.2481628359364128 1.0720229591187698 21.17384605489019 -10.463222679583989 4.5606725739047365 0.999429433301212 1.1600928975276972 0.5241396457322454 0.07190880359370089 0.00041864759464831433 4.9273496191219684e-05 0.06987104873939282 0.023208466563621414 3.4417341448795726e-11 10.463222679583989 0.16066346422648514 LEALITQTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEALITQTR 9 0 Q9UHB9-4;Q9UHB9 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 0 3879590.0 1078100.0 816990.0 1984500.0 False True 1043876.3056221029 1143218.3675465656 1464699.916276133 1.0 1.0951665071708465 1.4031355136499992 19.99351933885832 -6.949736018945131 0.5617323605203114 0.9960081065142289 1.5170561296185436 0.9991804167053681 0.00492558998508471 0.08359188245816208 0.036402114839885195 0.005268972237514725 0.025610328106374373 1.1227006680166671e-07 6.949736018945131 0.5210480231043148 LEALITQTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEALITQTR 9 0 Q9UHB9-4;Q9UHB9 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 0 5392700.0 1804500.0 1632800.0 1955400.0 False True 2471672.414778904 1560657.4970524495 1493574.7927271205 1.0 0.6314176133215669 0.6042770003810248 21.237056116413083 -13.999999999999984 0.370166638835088 6.139442909251604 0.6014706794827652 0.9997911855945985 0.002608132985185581 22.839683572892827 0.19750111897262843 93.15221432329871 0.007581445016687973 1.0000000000000368e-14 13.999999999999984 -5.5379722297688385 LEALK(ub)DLASLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEALKDLASLSR 12 1 Q92556;C9JIW2;C9IZR8 Q92556 ELMO1 Engulfment and cell motility protein 1 1 7999300.0 1440200.0 3915700.0 2643400.0 True False 1394481.6393256222 5479259.430105743 1951014.2396998385 1.0 3.929244584930884 1.3990963987473926 20.411297508331305 -6.610609223249407 2.151608186651544 2.956219718144887 1.4081835185682918 0.0522972794239458 1.2626932198277665 0.6108975357238972 5.360139061404982 0.4844940390852435 1.401584695128397 2.4512678926383416e-07 6.610609223249407 -1.5480361995765952 LEALK(ub)DLASLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEALKDLASLSR 12 1 Q92556;C9JIW2;C9IZR8 Q92556 ELMO1 Engulfment and cell motility protein 1 1 20691900.0 2537800.0 3492100.0 14662000.0 True False 3850028.1380318273 2868907.4710981664 11764049.273417106 1.0 0.745165325613641 3.0555748819620328 21.876437559144865 -6.879544788205856 1.082369631655557 0.8430020123937298 3.2178670836407797 0.9733148849644715 0.16896181571235264 0.12803245915464187 0.27474824743738463 0.12030186675865852 0.2905789468861371 1.3196392120721304e-07 6.879544788205856 2.37486507124705 up LEALK(ub)DLASLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEALKDLASLSR 12 1 Q92556;C9JIW2;C9IZR8 Q92556 ELMO1 Engulfment and cell motility protein 1 1 4204470.0 794970.0 1364300.0 2045200.0 True False 1088891.892256462 1304020.7148632172 1562165.8822161763 1.0 1.197566741139888 1.4346381797177035 20.05442929633805 -6.968700376535702 0.28753667214705214 0.952291643404029 1.6872127554051732 0.9999703959010312 0.0009667575431461127 0.07672666945656068 0.01053203850015464 0.004197459055430364 0.021560722235970393 1.0747306224439734e-07 6.968700376535702 0.7349211120011442 LEALK(ub)DLASLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEALKDLASLSR 12 1 Q92556;C9JIW2;C9IZR8 Q92556 ELMO1 Engulfment and cell motility protein 1 1 6427100.0 1440200.0 3204000.0 1782900.0 True False 1197590.111677929 3186739.416055795 2155696.1468018056 1.0 2.660960027125552 1.8000283450749988 20.19170278376558 -10.312406184145066 5.178147919702582 0.99966145447434 2.230494186100428 0.7314504527642475 0.35147388740384994 0.0013740374532859219 0.0001824554246961058 0.3404011178992624 0.11343770937841416 4.870727307611468e-11 10.312406184145066 1.230832731626088 LEALK(ub)DLASLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEALKDLASLSR 12 1 Q92556;C9JIW2;C9IZR8 Q92556 ELMO1 Engulfment and cell motility protein 1 1 14943300.0 2537800.0 3269000.0 9136500.0 True False 3285232.1275168 3087077.2763180495 7473750.748406607 1.0 0.9396831506854496 2.2749536283318195 21.647563881237314 -6.896322300669278 0.9842397244250263 0.9387447745027525 2.4050924636367577 0.9846456256484122 0.07629659925197677 0.11416274519739708 0.19308619912609298 0.05851842173593675 0.14962895158217351 1.2696315305581004e-07 6.896322300669278 1.4663476891340053 up LEASK(ub)LNESVMVFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEASKLNESVMVFTK 15 1 Q9NS91 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 15284300.0 6976300.0 8308000.0 0.0 True False 10583557.135846589 6825372.4892997295 0.0 1.0 0.6449034480271421 0.0 23.33532126328342 -7.545692211821913 0.6974785918103269 0.9945618810424777 1.033346142268449e-14 0.9870612261152764 0.047083273322502665 0.12042361105066325 0.14422924675478624 0.04201317776382336 0.07636990970678163 2.846477715638484e-08 7.545692211821913 -0.9945618810424673 down LEASK(ub)LNESVMVFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEASKLNESVMVFTK 15 1 Q9NS91 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 12290300.0 5185300.0 4006900.0 3098100.0 True False 7102445.537463589 3829861.9089536187 2366392.5873723524 1.0 0.5392314363766781 0.3331799694753356 22.75988443299595 -12.683403162415225 0.12374556461415998 2.6147515558614476 2.27396164516721e-11 0.9997169258492403 0.004690246094659727 7.38561489479243 0.09527276804040859 3.235745406318231 0.2691664398111767 2.0729882362934573e-13 12.683403162415225 -2.614751555838708 LEASK(ub)LNESVMVFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEASKLNESVMVFTK 15 1 Q9NS91 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 23998900.0 11273000.0 10358000.0 2367900.0 True False 9373998.978576113 10302199.398097977 2863016.942067411 1.0 1.0990186175231327 0.30542108534582924 23.160233206939996 -6.875635769798484 1.103899641914942 1.0584431586410346 0.25369249207401817 0.9699890548168171 0.06116782797364809 0.13156369646996707 0.29627374344899976 0.0428398773966283 0.10253808199978864 1.3315706995895138e-07 6.875635769798484 -0.8047506665670163 down LEASK(ub)LNESVMVFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEASKLNESVMVFTK 15 1 Q9NS91 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 37672300.0 6976300.0 13293000.0 17403000.0 True False 9030957.873431904 12553232.864513876 14235832.569859372 1.0 1.390022303331092 1.5763369477937266 23.106447585375868 -11.416906373997925 0.12965815279927784 1.6687669609398318e-15 1.8840829924353286 0.9997359264926086 0.0039023138839407467 4.138384538789608 0.08321835058318118 1.404628723269496 0.22044838854386986 3.8290728227474935e-12 11.416906373997925 1.8840829924353268 LEAVSHTSDMHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEAVSHTSDMHR 12 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5;Q5T0S3;Q5T0R8 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 3355410.0 1126400.0 528510.0 1700500.0 False True 1090643.0485601884 739546.7991432404 1255088.036093506 1.0 0.6780832648404559 1.1507780091299435 20.056747575353928 -6.723360255640576 1.7474339076247378 0.8048535999073008 1.1501735277160225 0.528237016178077 0.13541086257419208 0.34882657949353796 2.0834359267809726 0.061489725105485775 0.15374328420812067 1.890774534035214e-07 6.723360255640576 0.3453199278087218 LEAYQHLFYLLQTNPTYLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEAYQHLFYLLQTNPTYLAK 20 0 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 27872200.0 13186000.0 5648200.0 9038000.0 False True 12767417.647651477 7903555.714973892 6670676.665811878 1.0 0.6190410569382231 0.5224765766974754 23.605963417625837 -13.999999999999998 0.192723289394215 3.061750435648706 0.4550669373655842 0.9994881399089202 0.004664017119956925 12.396338853936712 0.13921761784521786 9.606906092306703 0.06499843365651929 1.0000000000000041e-14 13.999999999999998 -2.6066834982831217 LEAYQHLFYLLQTNPTYLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEAYQHLFYLLQTNPTYLAK 20 0 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 27717200.0 13186000.0 6337100.0 8194100.0 False True 10964743.238845421 6302960.784484134 9907448.424762275 1.0 0.5748388856160603 0.903573226380951 23.386368693060113 -9.956440813408351 6.138599078749035 1.0000001024014342 0.7392060559984764 0.4562728405100763 0.1342052326341357 1.8806063346482812e-07 3.217410222119493e-08 0.12994370808526054 0.04331455258047637 1.1055011192015951e-10 9.956440813408351 -0.2607940464029578 LECDK(ub)LASEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LECDKLASEK 10 1 Q08117;K7ELE3;Q08117-2 Q08117 AES Amino-terminal enhancer of split 1 2851040.0 809710.0 676430.0 1364900.0 True False 1061537.6512427938 575509.2807034883 1223673.241045303 1.0 0.5421468376837237 1.15273654176344 20.017724111832596 -6.706024030999671 1.80929473543876 0.7173877740108836 1.1511459272662068 0.44624419103254576 0.1930610010919302 0.3831216754659814 2.4421993408334797 0.08499458309065568 0.2169803848613872 1.9677774028376628e-07 6.706024030999671 0.4337581532553232 LECDK(ub)LASEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LECDKLASEK 10 1 Q08117;K7ELE3;Q08117-2 Q08117 AES Amino-terminal enhancer of split 1 15632200.0 1817500.0 3789700.0 10025000.0 True False 2757280.3770481707 3113398.425938757 8043554.355886417 1.0 1.1291555446645696 2.9172058173124604 21.39481454614284 -6.921434899019259 0.8140131099997449 0.9625510915684642 3.2152819942299464 0.99457031612506 0.0644702471238076 0.09733488849557201 0.10129302239313623 0.05597394756096038 0.17003938218097223 1.1982987353645683e-07 6.921434899019259 2.252730902661482 up LECDK(ub)LASEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LECDKLASEK 10 1 Q08117;K7ELE3;Q08117-2 Q08117 AES Amino-terminal enhancer of split 1 23083400.0 1817500.0 5401900.0 15864000.0 True False 2352789.5782811036 5101279.51634827 12976914.778385863 1.0 2.1681834888418505 5.51554414307909 21.16594086823529 -6.952477616855996 0.530947915195856 0.9475637287797551 6.888367419533367 0.9993816451648844 0.04758703949405734 0.08250585989981804 0.03196112079614877 0.05301650959607556 0.2768431228109219 1.1156356487194138e-07 6.952477616855996 5.9408036907536115 LEDEHLVFFCQMGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEDEHLVFFCQMGK 14 0 R4GNF9;Q8NFU3-2;Q8NFU3-3;Q8NFU3;Q8NFU3-4 R4GNF9 TSTD1 Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 0 6377900.0 1381500.0 2267200.0 2729200.0 False True 1811159.8784650317 1928942.5974763818 2446808.564334996 1.0 1.065031652043425 1.350962216769444 20.788482473805452 -6.942708637882788 0.6338672351011004 0.9968791544310501 1.4346271976998926 0.9984975552324389 0.005909040809180504 0.08655244116392702 0.04914420926032296 0.00587773970129123 0.024331047031824826 1.141015021921238e-07 6.942708637882788 0.4377480432688424 LEDEHLVFFCQMGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEDEHLVFFCQMGK 14 0 R4GNF9;Q8NFU3-2;Q8NFU3-3;Q8NFU3;Q8NFU3-4 R4GNF9 TSTD1 Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1 0 5190500.0 2026800.0 1021600.0 2142100.0 False True 1962460.3434142296 1429530.207573619 1581019.7483774775 1.0 0.728437755377296 0.8056314379463418 20.90423207023917 -10.011560519314786 6.677539427691966 1.0000000584719835 0.7670345966618181 0.923919061176657 0.031514188943426585 2.743135530366706e-08 4.085515814540005e-09 0.03051348996642349 0.010171160745593235 9.737320854586394e-11 10.011560519314786 -0.23296546181016542 LEDGPK(ub)FLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEDGPKFLK 9 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 31114100.0 9493400.0 14271000.0 7349700.0 True False 12445939.334216366 12141822.42792231 6589223.547300647 1.0 0.9755649695754199 0.5294275803824272 23.56917178337539 -6.918203904215523 0.8379388634421894 1.0104953912441128 0.46037414281631234 0.9936672801973416 0.01721286221746667 0.09924026842881112 0.1111751402286149 0.01469127043174722 0.04327939427423312 1.2072468913919152e-07 6.918203904215523 -0.5501212484278004 LEDGPK(ub)FLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEDGPKFLK 9 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 41031400.0 19515000.0 12792900.0 8723500.0 True False 18895507.006970927 17901171.684092168 6438553.650609643 1.0 0.9473771557168628 0.34074521780412315 24.171539893930305 -6.923981290750698 0.7946425767282409 1.01156376612463 0.2333643338252752 0.9952172224581897 0.020688141973692915 0.09588562556597406 0.09388844510549606 0.018211668061667362 0.0568140470741153 1.1912933274079021e-07 6.923981290750698 -0.7781994322993547 down LEDGPK(ub)FLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEDGPKFLK 9 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 41224900.0 14442700.0 2979200.0 23803000.0 True False 21910631.80280254 2447538.4834041595 19098326.616774485 1.0 0.11170551837264228 0.8716465498877882 24.38512774989194 -10.53591971834991 10.193583492186377 1.000009451472776 0.49167603413021527 0.3736565826314753 0.31024462696940297 6.664092129965011e-05 3.0339921976775883e-06 0.300398639922714 0.10013102279190252 2.9112552293769967e-11 10.53591971834991 -0.5083334173425607 LEDGPK(ub)FLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEDGPKFLK 9 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 24174000.0 9493400.0 9316700.0 5363900.0 True False 13003366.529488523 8905057.387793109 4097057.2929881355 1.0 0.684827069020824 0.31507665985550665 23.63238184489828 -7.174609205077301 0.31252771145108194 1.0633996655105173 3.399927612957289e-11 0.9999169871948549 0.0025503329556168528 0.08584654805345082 0.016044272518846464 0.008732670418678262 0.0385425930831948 6.689455898626408e-08 7.174609205077301 -1.063399665476518 down LEDGPK(ub)FLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEDGPKFLK 9 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 43144400.0 19515000.0 19226300.0 4403100.0 True False 16227587.161085125 19122724.10577825 5323767.852365823 1.0 1.1784083435173816 0.3280689728866523 23.95194516936458 -6.851934881957988 1.225818502576956 1.0953819813460028 0.2928053479689066 0.9430583092298561 0.08736534729492117 0.15534464618738344 0.44823277872466616 0.0557421950543442 0.1291523512903164 1.4062583624667576e-07 6.851934881957988 -0.8025766333770963 down LEDGPK(ub)FLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEDGPKFLK 9 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 28884600.0 14442700.0 7484100.0 6957800.0 True False 18696359.858179092 7067603.255947362 5691551.793056796 1.0 0.37802028360378925 0.304420316908209 24.15625407198439 -13.999999999999998 0.30113343887677585 6.710622356086373 0.28652275203114186 0.9996523583648601 0.005817319991514531 16.662655383603077 0.174310168655748 59.32647220615215 0.02646960871351527 1.0000000000000041e-14 13.999999999999998 -6.424099604055231 LEDK(ub)TVFDNFFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEDKTVFDNFFIK 13 1 Q9H040 Q9H040 SPRTN SprT-like domain-containing protein Spartan 1 4934240.0 848940.0 2199100.0 1886200.0 True False 1112968.5611466558 1871002.8520246628 1691034.1177079976 1.0 1.681092276404491 1.5193907328036107 20.085981409696394 -10.028007167350415 4.3589557284849345 0.9999660759987692 1.6002415047137746 0.948379780702721 0.06601437909654653 12166444.88309884 23819172.822223272 5807.981043816796 0.02415878980290375 9.375465340606481e-11 10.028007167350415 0.6002754287150054 LEDK(ub)TVFDNFFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEDKTVFDNFFIK 13 1 Q9H040 Q9H040 SPRTN SprT-like domain-containing protein Spartan 1 13437700.0 4339800.0 3878500.0 5219400.0 True False 4202035.42448642 5427205.276110309 3852282.5613563336 1.0 1.2915658074856975 0.9167658461201968 22.00265689376147 -6.699088980145702 1.8340275478037185 1.1812140694810063 0.9178976464812326 0.41324166018963016 0.12309463019898322 0.39745045660728157 2.5984416528199783 0.05355639324762409 0.13789265687367544 1.9994521711911975e-07 6.699088980145702 -0.26331642299977365 LEDK(ub)TVFDNFFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEDKTVFDNFFIK 13 1 Q9H040 Q9H040 SPRTN SprT-like domain-containing protein Spartan 1 4613440.0 848940.0 1864100.0 1900400.0 True False 1162816.0597408735 1781737.8982456357 1451564.6599665645 1.0 1.532261171764935 1.2483183800282538 20.149191471219286 -10.09144792979305 4.410317142868805 0.999965564926349 1.390289775758266 0.7158392361173017 0.11591915943383722 40310714.74056985 1.0574441243881523 15721.178667368857 0.03968221152536035 8.101250666794582e-11 10.09144792979305 0.39032421083191693 LEDK(ub)TVFDNFFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEDKTVFDNFFIK 13 1 Q9H040 Q9H040 SPRTN SprT-like domain-containing protein Spartan 1 10996900.0 4339800.0 4126700.0 2530400.0 True False 3608735.9857380106 4104468.6480141873 3059494.9407523023 1.0 1.137370166239744 0.8478023753590317 21.783062169195745 -6.77770246914459 1.5448266753249298 1.0780144614602238 0.8456717958555077 0.7591759780368629 0.05803823980200668 0.25415988488541275 1.19788798688152 0.029595419704464453 0.06996795373552252 1.6683898184805835e-07 6.77770246914459 -0.23234266560471617 LEDLNFPEIK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEDLNFPEIKR 11 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 36383000.0 10139000.0 14344000.0 11900000.0 True False 13292327.186215661 12203931.112474065 10668702.152860364 1.0 0.9181184710176049 0.8026210913559189 23.664090374250094 -6.966259345074882 0.33574442261867354 1.0131612891985153 0.7037646228392286 0.9999367889590438 0.0006437148929893263 0.07753623542172457 0.01336763679549325 0.0016525167481864732 0.010028640023448018 1.0807883505460444e-07 6.966259345074882 -0.30939666635928675 LEDLNFPEIK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEDLNFPEIKR 11 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 56027000.0 12133000.0 17516000.0 26378000.0 True False 11747844.55626843 24510230.144733302 19468810.476962354 1.0 2.08635975964247 1.657224045118486 23.485892745832672 -10.146525293628349 5.541535243061393 0.9999837505506814 1.8717919023806058 0.8462174976910074 0.17519392183185808 3.517322275907521e-05 5.416820731138053e-06 0.1696339376183534 0.0565435951342301 7.136326414250174e-11 10.146525293628349 0.8718081518299243 LEDLNFPEIK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEDLNFPEIKR 11 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 35448400.0 10139000.0 9686400.0 15623000.0 True False 13887662.296172516 9258422.819358682 11933169.165784916 1.0 0.666665319325221 0.8592640655637007 23.727300435772985 -10.2039280237395 5.3384692318542495 1.0000133354224332 0.7629646938554303 0.6688265055094132 0.07862810889750875 1.2480390662420164e-05 1.8611056935547014e-06 0.07613561971296301 0.02537711302529557 6.252763121478676e-11 10.2039280237395 -0.2370486415670029 LEDLNFPEIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEDLNFPEIKR 11 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 43583500.0 12133000.0 21805000.0 9645500.0 True False 10089127.083035918 21687532.137046367 11662329.454246895 1.0 2.149594504911358 1.155930474288127 23.266298021266948 -6.61079038886512 2.149954866155094 1.7676580672674473 1.1594614057297197 0.052831763018568734 0.495533419757577 0.6107532272386599 5.350438570140852 0.19021452640003791 0.5503256660906447 2.450245561332117e-07 6.61079038886512 -0.6081966615377277 LEDLNFPEIK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEDLNFPEIKR 11 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 131438000.0 23691000.0 50046000.0 57701000.0 True False 30668466.519426536 47260896.10603034 47200010.06225687 1.0 1.5410257332590642 1.5390404353070164 24.87025269517485 -10.089405536917292 4.838435966698301 0.999978788696705 1.540033084288011 0.9999898634638951 0.0008104945121208296 1.8545630747588907e-07 3.49021447905071e-08 0.0007847887103616748 0.0002615859765310836 8.139438818788804e-11 10.089405536917292 0.540054295591306 LEDSK(ub)LLGDLWQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEDSKLLGDLWQR 13 1 Q9H1I8;Q9H1I8-3;Q9H1I8-2 Q9H1I8 ASCC2 Activating signal cointegrator 1 complex subunit 2 1 12039900.0 2898700.0 5463700.0 3677500.0 True False 3800223.771050729 4648537.257335795 3296987.5770709203 1.0 1.223227245918341 0.8675772206328081 21.85765294153308 -6.737033979344433 1.6976605122495991 1.1332736826048748 0.8675046816563615 0.5915224390897301 0.09379922773531396 0.3232023783869803 1.8278149807997086 0.043731875130803476 0.10766112880615618 1.8321710670907019e-07 6.737033979344433 -0.2657690009485133 LEDSK(ub)LLGDLWQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEDSKLLGDLWQR 13 1 Q9H1I8;Q9H1I8-3;Q9H1I8-2 Q9H1I8 ASCC2 Activating signal cointegrator 1 complex subunit 2 1 16856900.0 4687100.0 6338100.0 5831700.0 True False 4538310.576088822 8868936.382754853 4304202.822750069 1.0 1.9542374269145375 0.9484152198458594 22.113723911532144 -6.6580843736836135 1.9796226373879189 1.6152026612960475 0.9526205242011063 0.2274753025960622 0.40648073003286334 0.48903390752650944 3.6820816849958615 0.16600600404631327 0.45053208898857605 2.197432919349174e-07 6.6580843736836135 -0.6625821370949412 LEDSK(ub)LLGDLWQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEDSKLLGDLWQR 13 1 Q9H1I8;Q9H1I8-3;Q9H1I8-2 Q9H1I8 ASCC2 Activating signal cointegrator 1 complex subunit 2 1 31496700.0 6347700.0 15097000.0 10052000.0 True False 9629924.979030918 12402822.396600612 8065217.794051886 1.0 1.2879459002648155 0.8375161604699757 23.199093128265012 -6.733986416395128 1.7083597266525057 1.1725023428754293 0.8375640910848977 0.5778511245709663 0.12101203441839581 0.32878540698039266 1.8815300572277829 0.05609003588472156 0.13857772087801815 1.8450731273784536e-07 6.733986416395128 -0.3349382517905316 LEDSK(ub)LLGDLWQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEDSKLLGDLWQR 13 1 Q9H1I8;Q9H1I8-3;Q9H1I8-2 Q9H1I8 ASCC2 Activating signal cointegrator 1 complex subunit 2 1 11221500.0 2898700.0 3694500.0 4628300.0 True False 3970427.7244220614 3531264.773922265 3535190.8628305914 1.0 0.8893915263087376 0.8903803590443587 21.92086300305597 -10.080017226012544 6.597119799884413 1.0000000938871576 0.889885942676548 0.9999395099483465 0.0004036892738728863 5.575961143929317e-10 7.769301938025377e-11 0.00039087079067928884 0.0001302901528958934 8.317307803795553e-11 10.080017226012544 -0.11011415121060963 LEDSK(ub)LLGDLWQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEDSKLLGDLWQR 13 1 Q9H1I8;Q9H1I8-3;Q9H1I8-2 Q9H1I8 ASCC2 Activating signal cointegrator 1 complex subunit 2 1 18828600.0 4687100.0 7754900.0 6386600.0 True False 3897531.323736717 7713122.8144728765 7722008.531698012 1.0 1.9789764786490545 1.9812563108010168 21.89412918696642 LEEAEK(ub)AADESER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEEAEKAADESER 13 1 J3KN67;A0A2R2Y2Q3;P06753;A0A494C0P6;Q5TCU3;CON__Q3SX28;A7XZE4;P07951-3;P07951;P07951-2;A0A2R8YEU4;H0YL80;H0YKX5;Q6ZN40;H0YKP3;A0A0S2Z4G6;P09493-2;P09493-9;P09493-8;P09493-7;P09493-6;P09493-4;P09493;P09493-3;P09493-10;P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;A0A494C0G0;P67936;A0A2R8Y5V9;A0A2R8YE05;K7ENT6;P67936-2;A0A2R8YH90;A0A2R8YGX3;A0A2R8YHD2;F5H7S3;H7BYY1;H0YKJ4;H0YK48;A0A494BZZ2;B7Z596;P09493-5 J3KN67;P06753-2;P67936;F5H7S3 TPM3;TPM2;TPM2b;TPM1;TPM4 Tropomyosin alpha-3 chain;Tropomyosin beta chain;Tropomyosin alpha-1 chain;Tropomyosin alpha-4 chain 1 3471500.0 1249300.0 1088000.0 1134200.0 True False 1209641.6553322466 1522444.0738450477 837118.994729347 1.0 1.2585909778602038 0.6920388290525754 20.206148295631472 -6.782601684984799 1.5256151117900572 1.145928328903398 0.687170743520802 0.7765045382741567 0.10948322233436195 0.24656552376464175 1.133649482334958 0.05651134420083693 0.13306269729497805 1.649674704017951e-07 6.782601684984799 -0.4587575853825959 LEEAEK(ub)AADESER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEEAEKAADESER 13 1 J3KN67;A0A2R2Y2Q3;P06753;A0A494C0P6;Q5TCU3;CON__Q3SX28;A7XZE4;P07951-3;P07951;P07951-2;A0A2R8YEU4;H0YL80;H0YKX5;Q6ZN40;H0YKP3;A0A0S2Z4G6;P09493-2;P09493-9;P09493-8;P09493-7;P09493-6;P09493-4;P09493;P09493-3;P09493-10;P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;A0A494C0G0;P67936;A0A2R8Y5V9;A0A2R8YE05;K7ENT6;P67936-2;A0A2R8YH90;A0A2R8YGX3;A0A2R8YHD2;F5H7S3;H7BYY1;H0YKJ4;H0YK48;A0A494BZZ2;B7Z596;P09493-5 J3KN67;P06753-2;P67936;F5H7S3 TPM3;TPM2;TPM2b;TPM1;TPM4 Tropomyosin alpha-3 chain;Tropomyosin beta chain;Tropomyosin alpha-1 chain;Tropomyosin alpha-4 chain 1 2768210.0 882350.0 1085000.0 800860.0 True False 1208578.639612175 1037061.1123848053 611713.3622294378 1.0 0.8580832710377799 0.5061427880487219 20.204879918544634 -6.955634258059654 0.4931262449262049 1.0074881773233473 0.3417346207856628 0.9995724637498209 0.004292628087896335 0.081299096912462 0.027186451864683568 0.005101697181045177 0.02902747934451638 1.1075561218738673e-07 6.955634258059654 -0.6657535565376844 LEEAEK(ub)AADESER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEEAEKAADESER 13 1 J3KN67;A0A2R2Y2Q3;P06753;A0A494C0P6;Q5TCU3;CON__Q3SX28;A7XZE4;P07951-3;P07951;P07951-2;A0A2R8YEU4;H0YL80;H0YKX5;Q6ZN40;H0YKP3;A0A0S2Z4G6;P09493-2;P09493-9;P09493-8;P09493-7;P09493-6;P09493-4;P09493;P09493-3;P09493-10;P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4;D6R904;A0A494C0G0;P67936;A0A2R8Y5V9;A0A2R8YE05;K7ENT6;P67936-2;A0A2R8YH90;A0A2R8YGX3;A0A2R8YHD2;F5H7S3;H7BYY1;H0YKJ4;H0YK48;A0A494BZZ2;B7Z596;P09493-5 J3KN67;P06753-2;P67936;F5H7S3 TPM3;TPM2;TPM2b;TPM1;TPM4 Tropomyosin alpha-3 chain;Tropomyosin beta chain;Tropomyosin alpha-1 chain;Tropomyosin alpha-4 chain 1 4020900.0 1249300.0 1695300.0 1076300.0 True False 1038848.3033740023 1686167.082409298 1301349.3537510675 1.0 1.6231119374531533 1.252684679297744 19.98655357106575 -10.229371531917044 4.847389591262591 0.9999195008942 1.437898308376141 0.6507508555353689 0.1512262948859529 0.00013159920921850863 2.0921445783632517e-05 0.1464510280059384 0.04880807679976498 5.896963885858185e-11 10.229371531917044 0.43797880748194096 LEEAGIK(ub)VHDVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEEAGIKVHDVR 12 1 Q5VWP2 Q5VWP2 FAM46C Protein FAM46C 1 13863000.0 2185700.0 2862300.0 8815000.0 True False 2865473.866348908 2435255.997158015 7902908.359450763 1.0 0.8498615275318975 2.7579760723905635 21.450342307992564 -6.887873217799745 1.0348419574258303 0.8921872507962804 2.9154366063872192 0.9795032236384014 0.12402223803392819 0.12088734119481323 0.23204321036921688 0.09155890046177978 0.22658660124185734 1.2945737070580673e-07 6.887873217799745 2.0232493555909388 up LEEAGIK(ub)VHDVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEEAGIKVHDVR 12 1 Q5VWP2 Q5VWP2 FAM46C Protein FAM46C 1 29977100.0 1994500.0 2822600.0 25160000.0 True False 1931185.6892341028 3949678.899664544 18569841.216179136 1.0 2.0452092834381785 9.615771968330932 20.881055459691154 -6.931993763800969 0.7302393386903526 0.8929646406229934 11.251948817883102 0.9969158193676144 0.21319728106640334 0.09161570315511222 0.07270445062793453 0.19658950928935237 0.677651507718756 1.16951618442535e-07 6.931993763800969 10.358984177260108 LEEAGIK(ub)VHDVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEEAGIKVHDVR 12 1 Q5VWP2 Q5VWP2 FAM46C Protein FAM46C 1 69829200.0 6702200.0 15883000.0 47244000.0 True False 10167727.396452423 13048554.555554593 37906202.692219175 1.0 1.2833304874113076 3.728089986504247 23.27749392057005 -6.928716438480021 0.7572553101244102 0.9609985411971406 4.2139638303516405 0.9962799053786089 0.07469924111060063 0.09330972739671829 0.08098588932208531 0.0675421892995482 0.22279016077639202 1.1783751124137405e-07 6.928716438480021 3.2529652891545 up LEEAGIK(ub)VHDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEEAGIKVHDVR 12 1 Q5VWP2 Q5VWP2 FAM46C Protein FAM46C 1 15526700.0 2185700.0 2253000.0 11088000.0 True False 2993812.356321558 2153455.010325314 8469242.764528131 1.0 0.7193019314581307 2.828915695616319 21.513552369515455 -6.873375579217464 1.116138332285562 0.8375114295174754 2.960627480863935 0.96793494776401 0.16749343271169126 0.13365676871014387 0.3091594559106111 0.11621107659333049 0.2768539561550724 1.3385186316810558e-07 6.873375579217464 2.1231160513464595 up LEEAGIK(ub)VHDVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEEAGIKVHDVR 12 1 Q5VWP2 Q5VWP2 FAM46C Protein FAM46C 1 23938600.0 1994500.0 5611100.0 16333000.0 True False 1658515.1213315031 5580871.89058385 19748154.78474052 1.0 3.3649810115106864 11.907129775751539 20.66146073512543 -6.947221316348986 0.5885599458492071 0.9008343445376144 14.800043362051552 0.9989647907928341 0.15073217108880543 0.08462109306455304 0.040730773723887205 0.15650240795408002 0.7153127103181962 1.129220317658729e-07 6.947221316348986 13.899209017513938 LEEAGIK(ub)VHDVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEEAGIKVHDVR 12 1 Q5VWP2 Q5VWP2 FAM46C Protein FAM46C 1 67390200.0 6702200.0 13361000.0 47327000.0 True False 8676130.020113144 12617448.604737077 38713971.616028 1.0 1.454271498408519 4.462124417946787 23.048620242662498 -6.933787110439319 0.7150201087932367 0.9600571747525689 5.143727243118255 0.9972316645245167 0.08082836574350223 0.09071845685913929 0.06839196535690427 0.07537399801344943 0.26671856211600414 1.1646968196046596e-07 6.933787110439319 4.183670068365686 up LEEAYEK(ub)CDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEEAYEKCDR 10 1 Q96A65;Q96A65-2 Q96A65 EXOC4 Exocyst complex component 4 1 6143700.0 1272900.0 1828900.0 3041900.0 True False 1931082.3614550855 1502518.5057390793 2440667.131687864 1.0 0.7780706487355206 1.2638855702916796 20.880978266460414 -6.782473529303341 1.5259544395892584 0.8747422153473289 1.2680560422039677 0.7761348106961712 0.09395668834071468 0.2467499608344119 1.1349710485379174 0.04848529077400335 0.1141840833366882 1.650161577305416e-07 6.782473529303341 0.39331382685663885 LEEAYEK(ub)CDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEEAYEKCDR 10 1 Q96A65;Q96A65-2 Q96A65 EXOC4 Exocyst complex component 4 1 3278250.0 687180.0 866670.0 1724400.0 True False 571420.6172356895 862001.0766894734 2084964.0672752394 1.0 1.5085228826000345 3.6487379075705806 19.124193565046205 -6.943707630269102 0.6241172277416451 0.9766282242005992 4.294821102520654 0.9986103220773748 0.04278438440724142 0.08611514813406247 0.04720749185911704 0.04292671479127463 0.18141235019010132 1.138393401395281e-07 6.943707630269102 3.3181928783200547 up LEEDINSSMTNSTAASRPPVTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEEDINSSMTNSTAASRPPVTLR 23 1 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 13477400.0 2999800.0 2559200.0 7918400.0 False True 2904572.9910074985 3581101.906051695 5844333.493091921 1.0 1.2329185450455942 2.0121145212001434 21.46989465411171 -6.9489787607146445 0.5699434334857862 0.9902911680630122 2.292622263107633 0.9991186972072285 0.012848157449867907 0.08389840493282122 0.03767938204118345 0.013612713804944656 0.0649214540903241 1.1246599744125456e-07 6.9489787607146445 1.302331095044621 up LEEEGEQFVK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEEEGEQFVKK 11 1 P22307-7;P22307-8;P22307;P22307-6;P22307-2;P22307-4;H0YF61 P22307-7 SCP2 Non-specific lipid-transfer protein 1 6833400.0 2518400.0 2077200.0 2237800.0 True False 3301646.7882202906 1767289.8568621827 2006253.9224933549 1.0 0.5352752642007528 0.6076524992471408 21.654754357613083 -10.678080174326784 6.711443192625492 1.0029610163706248 0.5714638817239776 0.9790541916916162 0.029547882476189113 0.0013154250018372804 6.309531852356976e-05 0.028747040436179594 0.009536538062164535 2.0985524378532907e-11 10.678080174326784 -0.4314971346466473 LEEFEEK(ub)ASELYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEEFEEKASELYK 13 1 Q9NSV4-2;Q9NSV4-1;Q9NSV4-7;Q9NSV4-6;Q9NSV4-5;Q9NSV4-4;Q9NSV4 Q9NSV4-2 DIAPH3 Protein diaphanous homolog 3 1 15910400.0 2204500.0 7331900.0 6374000.0 True False 3344387.670537935 6023465.16060383 5114176.106176554 1.0 1.8010666686960284 1.5291816051199452 21.673310658951632 -10.243912160671716 4.865635754895993 0.9998606667983083 1.665124136908937 0.8886347174102612 0.11099661241087455 0.00016780133130591762 2.60751663155971e-05 0.10749425463673076 0.035824002612262526 5.7027960395990476e-11 10.243912160671716 0.6652634701106286 LEEFLQK(ub)EVCLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEEFLQKEVCLR 12 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 14655600.0 3740900.0 3908600.0 7006100.0 True False 4904356.126927136 3325452.115603471 6281175.979256708 1.0 0.6780608971981527 1.2807340692023172 22.225632312605978 -6.761575675937946 1.6065457142737674 0.8133754775085849 1.2831119193088592 0.6974450670435174 0.13543984324917252 0.2802362709924391 1.4258738062419702 0.06650696808725622 0.15957861641361903 1.7315072888202193e-07 6.761575675937946 0.4697364418002743 LEEFLQK(ub)EVCLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEEFLQKEVCLR 12 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 16009800.0 5695500.0 2891000.0 7423300.0 True False 5514699.470059078 4045391.376365831 5478915.0357735455 1.0 0.7335651558764803 0.9935110817044851 22.394850835944236 -10.75382591230387 9.21075212183259 1.0007371618537528 0.8635381188213395 0.26871055155312484 0.10612247983232909 0.0016147363530614762 4.31566415493847e-05 0.10328261849886694 0.034250883087403594 1.762682479143e-11 10.75382591230387 -0.13719904303241337 LEEFLQK(ub)EVCLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEEFLQKEVCLR 12 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 122301000.0 12710000.0 20354000.0 89237000.0 True False 19281999.22546481 16721669.673472162 71599267.83603352 1.0 0.8672165929448155 3.713269925946051 24.200751307228206 -6.895957897840129 0.9864757691609115 0.868194431366314 3.988647173052875 0.9844455163087525 0.16356289717710346 0.114441817224041 0.19467730142080517 0.12524003859321683 0.31972022488249097 1.270697285468413e-07 6.895957897840129 3.120452741686561 up LEEFLQK(ub)EVCLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEEFLQKEVCLR 12 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 14500900.0 3740900.0 3615100.0 7144900.0 True False 5124011.824021288 3455372.92846296 5457421.77383451 1.0 0.6743491325028222 1.06506814606676 22.28884237412887 -6.685548714391689 1.882510175939345 0.7949867185166779 1.0636392130387897 0.3495321211224598 0.137855169511434 0.42631879150170654 2.9256417174698828 0.05866362303128102 0.15361117909584487 2.0627722751638518e-07 6.685548714391689 0.2686524945221118 LEEFLQK(ub)EVCLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEEFLQKEVCLR 12 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 15858000.0 5695500.0 2794300.0 7368200.0 True False 4736060.603431224 2779246.551274875 8908856.553292416 1.0 0.5868266443341839 1.8810689514483931 22.175256111378513 -6.8208218843491 1.3683174996805376 0.7774864115122724 1.9098246879856589 0.886265158887247 0.18203154024739723 0.1924136806294508 0.7076567794121295 0.10453518659872862 0.2408851756256532 1.5106996049837005e-07 6.8208218843491 1.1323382764733865 LEEFLQK(ub)EVCLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEEFLQKEVCLR 12 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 109548000.0 12710000.0 19835000.0 77003000.0 True False 16453345.55155591 18731164.813633695 62989244.11750165 1.0 1.1384411003184933 3.828354781714596 23.971877629320655 -6.917572773748107 0.8425379163528214 0.935297800596476 4.238794059917069 0.9934794906746264 0.10512765102807088 0.0996213411564945 0.11317217212755769 0.08943245520911357 0.2619782565591028 1.209002576130031e-07 6.917572773748107 3.303496259320593 up LEEFPNTCK(ub)MR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEEFPNTCKMR 11 1 H3BUW8;E7EN44;Q86WA8-2;Q86WA8 H3BUW8 LONP2 Lon protease homolog 2, peroxisomal 1 2367010.0 1442200.0 290740.0 634070.0 True False 1199253.2002929528 289173.7259126282 766651.1053915647 1.0 0.24112816696423156 0.6392737623750244 20.19370485880363 -10.771422293710515 6.716980719832015 1.0163184948819508 0.4402009646765698 0.7249604641022962 0.16254225868217306 0.038430078802831356 0.0013077671507540722 0.1522652758598372 0.052460288410916184 1.6926910826768075e-11 10.771422293710515 -0.576117530205381 LEEGLVNNK(ub)YDTALNLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEEGLVNNKYDTALNLLK 18 1 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 1 13111000.0 5108400.0 4345900.0 3656700.0 True False 4946236.6381967915 6081240.5335691 2698900.5713514425 1.0 1.2294681751793597 0.5456472807041756 22.237899832219494 -6.81621222178942 1.3882141738790013 1.124175552003721 0.531901363552457 0.8754388884276357 0.10028788547714076 0.19845184406705962 0.7524842498858887 0.05678459868120563 0.1310278598119238 1.526819782102032e-07 6.81621222178942 -0.5922741884512641 LEEGLVNNK(ub)YDTALNLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEEGLVNNKYDTALNLLK 18 1 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 1 31061500.0 8308500.0 5688000.0 17065000.0 True False 12604601.932712385 4672931.959453154 13692095.270144796 1.0 0.37073221228237435 1.0862774836712668 23.587447221220362 -6.674445102594763 1.921412613519633 0.599892399566446 1.0834621380346736 0.29897934883786714 0.2670274815453073 0.4509865263834716 3.2139249471731834 0.11171025607289957 0.2967646113984708 2.1161911674833527e-07 6.674445102594763 0.4835697384682276 LEEGLVNNK(ub)YDTALNLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEEGLVNNKYDTALNLLK 18 1 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 1 39099600.0 8308500.0 6733100.0 24058000.0 True False 10755517.035019852 6358397.066129414 19679690.855925802 1.0 0.5911753982097318 1.8297298764763175 23.35857354331281 -6.817759453999224 1.3815785022420708 0.7791362396242001 1.8554832312437526 0.8791459153559535 0.1791317628368545 0.19640799203674558 0.7372533135107957 0.10190465667448927 0.2350214245434222 1.521389960283215e-07 6.817759453999224 1.0763469916195525 LEEK(ub)IGQLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEEKIGQLTR 10 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 1 5481400.0 1853300.0 2027500.0 1600600.0 True False 2429694.247382732 1725004.9031331018 1434985.2660393529 1.0 0.7099678920470253 0.590603228198412 21.212343345896794 -13.999999999999998 0.12197884076311051 2.380570947051662 0.40507227493929515 0.999683289130622 0.0030593391962754346 11.956609593461032 0.10773679136424728 3.9913974595401185 0.16466900638361903 1.0000000000000041e-14 13.999999999999998 -1.9754986721123668 LEEK(ub)IGQLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEEKIGQLTR 10 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 1 3436480.0 797580.0 1038300.0 1600600.0 True False 772261.2594732188 1452898.6046629688 1181354.843029267 1.0 1.881356324482769 1.5297346960471672 19.558729474757524 -9.972647594760508 4.980384246794322 0.9999946059533203 1.7055455102774184 0.8429724842563302 0.14354892874209696 98662522.0786096 16.658381063470813 6103.164013281896 0.049140616479547594 1.0650068601137318e-10 9.972647594760508 0.7055509043240981 LEEK(ub)IGQLTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEEKIGQLTR 10 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 1 18372200.0 2447400.0 4201800.0 11723000.0 True False 3712884.728906571 3451955.961186756 9405943.911626566 1.0 0.9297234396510183 2.533325055420338 21.8241090949622 -6.89665214430317 0.9822059705227497 0.9270666902459149 2.690650679321162 0.9848253258980625 0.0911495457577325 0.11391116505895128 0.19165035949164788 0.07001695007147946 0.179294025177556 1.2686676203422463e-07 6.89665214430317 1.7635839890752472 up LEEK(ub)IGQLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEEKIGQLTR 10 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 1 5340200.0 1853300.0 1500100.0 1986800.0 True False 2538515.093549321 1433820.621832668 1517558.7594304224 1.0 0.5648265103785212 0.5978135656103546 21.275553407419686 -10.075256884429256 5.365363670294291 1.0000045740291 0.5813200379940803 0.9953658846698228 0.013466908907087025 7.368345252361754e-07 1.270046908979175e-07 0.013039420860268802 0.004346426159988769 8.408976050456253e-11 10.075256884429256 -0.41868453603501965 LEEK(ub)IGQLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEEKIGQLTR 10 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 1 11541800.0 2447400.0 0.0 9094400.0 True False 3168207.5454663956 0.0 7439312.5164241195 1.0 0.0 2.3481140075780513 21.59523541705465 -6.791021940328771 1.4925665938171067 0.4418450535528047 2.373680616757186 0.8045196584436834 0.42538304957658574 0.23383497935910916 1.029134447636359 0.22433113327523502 0.5247534653306911 1.6179982951555443e-07 6.791021940328771 1.9318355632043813 LEELDADK(ub)AEMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEELDADKAEMR 12 1 Q9UG63;Q9UG63-2;C9JHK9;C9JZV3 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 19688100.0 5565300.0 8446600.0 5676200.0 True False 7296162.194441857 7186400.204588919 5088881.273955114 1.0 0.984956202051463 0.6974737044403663 22.798706370443607 -6.917737552522264 0.8413338956536978 1.0068749779464046 0.6534437737607041 0.993529070523325 0.01119769450240077 0.09952140863690517 0.11264652727503421 0.009534111123273308 0.027969795910292302 1.2085439468308557e-07 6.917737552522264 -0.3534312041857005 LEELDADK(ub)AEMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LEELDADKAEMR 12 1 Q9UG63;Q9UG63-2;C9JHK9;C9JZV3 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 28819000.0 10830900.0 10467900.0 7520200.0 True False 10487079.00803491 14647787.059377361 5550434.018835869 1.0 1.3967461338047165 0.5292640605246971 23.322109560672956 -6.782349316260009 1.5266794894714533 1.2239611938059856 0.5218740432655252 0.7756307961661579 0.16795480731464635 0.24693919329751488 1.1369534181213712 0.08663511464312358 0.20402800906646673 1.6506336093364888e-07 6.782349316260009 -0.7020871505404603 LEELDADK(ub)AEMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 LEELDADKAEMR 12 1 Q9UG63;Q9UG63-2;C9JHK9;C9JZV3 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 91508400.0 31498000.0 34456200.0 25554200.0 True False 47784768.8122494 28307221.90248064 20503401.16919625 1.0 0.5923900566245749 0.42907817027965406 25.5100475029047 -13.999999999999998 0.1261116108651147 2.937271987943109 0.18866175283716816 0.9996635576144953 0.0044037278313114325 11.944484839651757 0.11003158899193051 5.757561126922439 0.21355012725156192 1.0000000000000041e-14 13.999999999999998 -2.7486102351059407 LEELDADK(ub)AEMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEELDADKAEMR 12 1 Q9UG63;Q9UG63-2;C9JHK9;C9JZV3 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 17355400.0 5565300.0 6418100.0 5372000.0 True False 7622941.806577461 6134527.120181493 4103244.2398128724 1.0 0.8047453694173964 0.5382756872513949 22.8619164319665 -6.966780532702815 0.3260580111110271 1.0339934713094452 0.30035550949625683 0.9999452767942911 0.001399923526256546 0.07736191679681521 0.012757158854107475 0.0039447211580418435 0.023317417136559573 1.0794920972501298e-07 6.966780532702815 -0.7336379618131883 LEELDADK(ub)AEMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEELDADKAEMR 12 1 Q9UG63;Q9UG63-2;C9JHK9;C9JZV3 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 21792500.0 8523200.0 10113000.0 3156300.0 True False 7087418.441781226 10058519.261726677 3816267.7369176783 1.0 1.4192077615215206 0.5384566705445665 22.756828797712053 -6.7772815729818365 1.5465280755171738 1.2382035939398566 0.5320731895982198 0.7576349197488852 0.17708417913572688 0.2548191012578278 1.2036176260223417 0.0902052315601044 0.21332942254529358 1.6700075209595332e-07 6.7772815729818365 -0.7061304043416368 LEELDADK(ub)AEMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEELDADKAEMR 12 1 Q9UG63;Q9UG63-2;C9JHK9;C9JZV3 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 66079000.0 20517000.0 30832000.0 14730000.0 True False 26559660.95053285 29116172.09649375 12049291.14256327 1.0 1.0962554134528442 0.45366886139868184 24.66273339417548 -6.868757378920244 1.140564925624535 1.0540568055852082 0.41690058439887817 0.9634315896920038 0.054112435470683326 0.1380563641174392 0.3364259553497016 0.03684519430984245 0.08705462981461339 1.3528281172411254e-07 6.868757378920244 -0.63715622118633 down LEELKESILADK(ub)SLATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEELKESILADKSLATR 17 2 B1AJY7;O75832;B1AJY5;O75832-2;B1AJY6 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 1 37820800.0 8479200.0 15328300.0 14013300.0 True False 10976491.55001989 14475266.630341386 11463023.18860026 1.0 1.31875167619613 1.0443248770668885 23.38791365915278 -9.979388540277355 7.65317992960249 0.9999999971942761 1.1815382766315092 0.36847748182450535 0.11203427160198287 5.3452332885747224e-09 6.336303636781676e-10 0.10847671864616834 0.03615890567657985 1.0486038785121374e-10 9.979388540277355 0.1815382794372331 LEELLSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEELLSKR 8 1 A0AVF1-3;A0AVF1;Q96CU4;A0AVF1-2;B7Z6R6;B7Z2T3;F8WEZ4 A0AVF1-3 TTC26 Intraflagellar transport protein 56 1 1751640.0 468320.0 321930.0 961390.0 True False 453453.43794540694 450478.327842772 709573.1179182216 1.0 0.9934389953770885 1.5648202407137775 18.790594892238015 -6.904305209326112 0.9336695614596 0.9789674982751668 1.6303236014218112 0.9885884584931809 0.028609678007268335 0.10830512499401153 0.16009553102750032 0.0227825867550056 0.060663687504110365 1.2465071979367832e-07 6.904305209326112 0.6513561031466444 LEELLSK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEELLSKR 8 1 A0AVF1-3;A0AVF1;Q96CU4;A0AVF1-2;B7Z6R6;B7Z2T3;F8WEZ4 A0AVF1-3 TTC26 Intraflagellar transport protein 56 1 1848780.0 468320.0 811630.0 568830.0 True False 389428.8300937422 807257.5880940579 687769.7230272422 1.0 2.0729271325385366 1.7660986292711927 18.571000167672292 -10.116731818053905 4.408250314665325 0.9998857026556852 1.919512880945121 0.9229266525118143 0.12526221211295252 29342732.600639947 38814099.77262776 37956.86469761612 0.04584127864924976 7.643076068133074e-11 10.116731818053905 0.9196271782894357 LEELMGK(ub)IDEK(ub)EEKDFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEELMGKIDEKEEKDFR 17 3 S4R3E6;Q5VZ72 S4R3E6 IZUMO3 Izumo sperm-egg fusion protein 3 2 9569600.0 2887400.0 2898700.0 3783500.0 True False 2795741.067482851 4056166.0265208026 2792487.847432981 1.0 1.4508375162842877 0.9988363657537144 21.414799318464965 -10.636288180478507 3.2071827517252394 0.9846804820767755 1.2248369407919903 0.24806920558182977 0.1845286973528935 104129529.32152061 124608538.17112507 13305079.038213566 0.07294137692782354 2.3105311051948926e-11 10.636288180478507 0.24015645871521485 LEELMGK(ub)IDEK(ub)EEKDFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEELMGKIDEKEEKDFR 17 3 S4R3E6;Q5VZ72 S4R3E6 IZUMO3 Izumo sperm-egg fusion protein 3 2 10187500.0 2887400.0 2416500.0 4883600.0 True False 2401001.033508438 2403481.8348623076 5904738.180784838 1.0 1.001033236270725 2.4592818155336653 21.19520459389924 -6.907050231099372 0.9155920192647385 0.9505305741341654 2.6363104517307785 0.9897598926986447 0.06958753786121614 0.10640097126753481 0.14958879621235643 0.05615403912560125 0.15201759492819975 1.2386533138925792e-07 6.907050231099372 1.685779877596613 up LEELQTLCK(ub)TPPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEELQTLCKTPPR 13 1 O94986;O94986-3;O94986-1;O94986-2 O94986 CEP152 Centrosomal protein of 152 kDa 1 3487300.0 1153300.0 1181400.0 1152600.0 True False 1511987.468573087 1005139.7250611327 1033340.0085199028 1.0 0.664780460124922 0.683431595828701 20.528014751804864 -10.181893732165817 7.1444172756950834 1.0000004657685593 0.6741060279768177 0.9975495046691611 0.007614294266277372 5.648930808104434e-08 6.473690515185448e-09 0.007372519267634566 0.002457502907201234 6.578187798220578e-11 10.181893732165817 -0.32589443779174154 LEELTMDGAK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEELTMDGAKAK 12 1 A0A494C128;O00567;H0YDU4;Q5JXT2 A0A494C128 NOP56 Nucleolar protein 56 1 6763600.0 1152300.0 1554200.0 4057100.0 True False 1510676.4588890746 1322319.4182241492 3637310.210451234 1.0 0.8753160946166858 2.407736076807637 20.52676328135782 -6.88718584588733 1.0389307170990576 0.9120204058003147 2.5324735159355902 0.979033413146707 0.10061584645107063 0.12145430268504863 0.23544576023756564 0.07405263146355964 0.18283227538377408 1.2966242930396747e-07 6.88718584588733 1.6204531101352755 up LEELTMDGAK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEELTMDGAKAK 12 1 A0A494C128;O00567;H0YDU4;Q5JXT2 A0A494C128 NOP56 Nucleolar protein 56 1 7998200.0 1282300.0 1369600.0 5346300.0 True False 1241594.0883955332 1916488.4223696443 3945943.6444379413 1.0 1.5435708338836025 3.1781269589783085 20.243762162871363 -6.951398215808771 0.5432825807502184 0.976441097792111 3.8211655834749827 0.999306454247067 0.024377275214006504 0.08292922083548421 0.033676815846757344 0.026692972927401273 0.13543723297904495 1.1184119124485387e-07 6.951398215808771 2.844724485682872 LEELTMDGAK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEELTMDGAKAK 12 1 A0A494C128;O00567;H0YDU4;Q5JXT2 A0A494C128 NOP56 Nucleolar protein 56 1 5480800.0 1152300.0 1326500.0 3002000.0 True False 1578336.4497366224 1267890.8438511004 2292989.428130723 1.0 0.80330834662196 1.4527887438152716 20.58997334288071 -6.825471979636529 1.3480239313769655 0.8945293257916677 1.468703206238327 0.8965103815459529 0.08748044198907987 0.1864659796378225 0.6642525110345129 0.05097546021294174 0.11735519464558185 1.4946104704340147e-07 6.825471979636529 0.5741738804466593 LEELTMDGAK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEELTMDGAKAK 12 1 A0A494C128;O00567;H0YDU4;Q5JXT2 A0A494C128 NOP56 Nucleolar protein 56 1 6548900.0 1282300.0 2017700.0 3248900.0 True False 1066289.2655218786 2006830.2496179098 3928229.96878365 1.0 1.88206926066699 3.6840190516792264 20.02416743830564 -6.959627885344489 0.4406464159982032 0.9360024721775593 4.700416750333497 0.9997561494418412 0.017442618061202113 0.07983431258386027 0.021624461403968575 0.023776841103430306 0.14928466597794382 1.0974180894006351e-07 6.959627885344489 3.7644142781559378 LEELTMDGAK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEELTMDGAKAK 12 1 A0A494C128;O00567;H0YDU4;Q5JXT2 A0A494C128 NOP56 Nucleolar protein 56 1 13988200.0 883600.0 1196500.0 11908100.0 True False 1143837.618359936 1129913.7231919703 9740947.98742414 1.0 0.987827035110167 8.516023455664069 20.125450827896245 -6.906532281809873 0.9190259927688644 0.7405866400323428 9.420068356585503 0.9895458387256312 0.3625587942383041 0.10675602537373942 0.15153649042256576 0.2918335622489917 0.7874914207341286 1.2401314407210287e-07 6.906532281809873 8.67948171655316 up LEELYTK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEELYTKK 8 1 Q9UNM6;J3KNQ3;A0A087WUL9;E9PL38;E9PQG3;E9PPD2;F8W8J6 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 6151500.0 2707900.0 1856200.0 1587400.0 True False 2621939.196729518 2597390.3399551255 1171612.319020776 1.0 0.9906371372741924 0.44684953811369443 21.322202798898367 -6.910636569712394 0.8913896109335196 1.0164996639732202 0.3756090095325562 0.9911595569578002 0.02431253876432421 0.10399855490017092 0.13649542891360092 0.01996786167567546 0.055366420688600176 1.2284668179996917e-07 6.910636569712394 -0.6408906544406641 down LEELYTK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEELYTKK 8 1 Q9UNM6;J3KNQ3;A0A087WUL9;E9PL38;E9PQG3;E9PPD2;F8W8J6 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 14029500.0 5884600.0 3978200.0 4166700.0 True False 8927368.421885936 3268259.128181528 3343149.918670517 1.0 0.36609434871862245 0.3744832475463431 23.08980353479286 -10.04983727700053 5.438632359566231 1.0000042811028775 0.3702887981319645 0.9998669141841456 0.0034247536071183417 1.7777650239403886e-07 3.105441493062805e-08 0.003316025992180377 0.001105334473504847 8.915849377699206e-11 10.04983727700053 -0.6297154829709131 LEELYTK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEELYTKK 8 1 Q9UNM6;J3KNQ3;A0A087WUL9;E9PL38;E9PQG3;E9PPD2;F8W8J6 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 4477500.0 1956300.0 1427200.0 1094000.0 True False 2679596.97701966 1364141.584880732 835619.7316372455 1.0 0.5090846110738553 0.3118453031569884 21.353584598746625 -13.999999999999998 0.1256834012474528 3.3334124100147298 0.019862250371586815 0.9996655726721103 0.005291257947838678 11.945551566225602 0.10979719040792055 6.915102245695468 0.2593267216963575 1.0000000000000041e-14 13.999999999999998 -3.313550159643143 LEELYTK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEELYTKK 8 1 Q9UNM6;J3KNQ3;A0A087WUL9;E9PL38;E9PQG3;E9PPD2;F8W8J6 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 8506200.0 2707900.0 4208400.0 1589900.0 True False 2251738.8303101403 4185728.5138980076 1922340.73913298 1.0 1.8588872108767125 0.8537139002342509 21.102608074332643 -6.680458850479404 1.900472113370877 1.543207982261686 0.8575449686323274 0.3261574479414395 0.36398070911394026 0.4374886333013344 3.055461766187402 0.15366418244628133 0.4050089456081534 2.0870898668801407e-07 6.680458850479404 -0.6856630136293586 LEELYTK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEELYTKK 8 1 Q9UNM6;J3KNQ3;A0A087WUL9;E9PL38;E9PQG3;E9PPD2;F8W8J6 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 14531500.0 5884600.0 5284000.0 3362900.0 True False 7617730.702807706 4989940.754990699 2750886.706267889 1.0 0.6550429451583961 0.3611162974367131 22.86092985688531 -7.481500360620346 0.22772408337568958 1.1576749000000075 6.430978218004568e-16 0.9999181745496298 0.0023618395572714878 0.1261906043069985 0.021061816436878638 0.027693156573774736 0.0636947982047235 3.299891339012633e-08 7.481500360620346 -1.1576749000000068 down LEENDDDAYLNSPWADNTALK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEENDDDAYLNSPWADNTALKR 22 1 P57076;C9J818 P57076 C21orf59 UPF0769 protein C21orf59 1 23497900.0 6041600.0 5346300.0 12110000.0 True False 5849812.715004642 7481105.470586194 8938027.707787333 1.0 1.278862390140683 1.5279168997772334 22.47995900607847 -6.972462987913741 0.1903793907433365 0.8320391334603802 1.981546603694344 0.9999957619881276 0.00044387933829372224 0.07551134531308601 0.006076197414568761 0.008764310288368528 0.027121201677009085 1.0654596619765822e-07 6.972462987913741 1.149507470233964 LEENDDDAYLNSPWADNTALK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEENDDDAYLNSPWADNTALKR 22 1 P57076;C9J818 P57076 C21orf59 UPF0769 protein C21orf59 1 53976800.0 5695800.0 21802000.0 26479000.0 True False 8640945.018757062 17911262.760196514 21245414.043842006 1.0 2.072836098518877 2.4586910341084436 23.042757670985928 -10.084638209994983 0.24463629625330477 6.844324440342918e-16 2.682510916416305 0.9991388010744081 0.018110403164396716 1.5729741400740378 0.11275077622140081 1.2312658363181561 0.1783618774209845 8.229279064426405e-11 10.084638209994983 2.682510916416304 LEENDDDAYLNSPWADNTALK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEENDDDAYLNSPWADNTALKR 22 1 P57076;C9J818 P57076 C21orf59 UPF0769 protein C21orf59 1 12546100.0 2289000.0 3139800.0 7117300.0 True False 3135305.1578990933 3001073.2540698745 5436340.325394675 1.0 0.9571869731751518 1.7339110713668013 21.580174436071538 -6.893864481531712 0.9992717413943215 0.9620489585168176 1.8059943043703952 0.9832576220852244 0.04612692728204962 0.11606268007819906 0.2039947356802859 0.03498211360544861 0.08851332584988816 1.2768371745078773e-07 6.893864481531712 0.8439453458535776 LEENDDDAYLNSPWADNTALK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEENDDDAYLNSPWADNTALKR 22 1 P57076;C9J818 P57076 C21orf59 UPF0769 protein C21orf59 1 19435400.0 6041600.0 7794600.0 5599200.0 True False 5023858.088260923 7752608.942693034 6769966.83222428 1.0 1.543158426550362 1.3475633095694781 22.260364281512746 -10.148789380902707 4.648527934420856 0.9999516846749675 1.445360868063519 0.8736206634977401 0.07985137215076746 55851959.021989845 2.7036551682963346 29403.864866041873 0.027335248606146643 7.099219742115708e-11 10.148789380902707 0.4454091833885515 LEENDDDAYLNSPWADNTALK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEENDDDAYLNSPWADNTALKR 22 1 P57076;C9J818 P57076 C21orf59 UPF0769 protein C21orf59 1 44401500.0 5695800.0 7831700.0 30874000.0 True False 7373325.3810033025 7395859.010382409 25255248.793991737 1.0 1.0030561013131418 3.4252182684165238 22.813883993078377 -6.907172775015655 0.9147706913815461 0.9181330120803203 3.72002765592192 0.9898100053970671 0.11533419494378264 0.10631814555964655 0.14912844738257283 0.09312456254191721 0.2522992538047414 1.2383038551237135e-07 6.907172775015655 2.8018946438415995 up LEETVQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEETVQAK 8 0 P31146;H3BRY3 P31146 CORO1A Coronin-1A;Coronin 0 11348620.0 539820.0 5774400.0 5034400.0 False True 707709.2476243159 4912882.028434906 4513488.581374799 1.0 6.9419497412627935 6.377602944324903 19.432797245529287 -10.436470791774385 6.1932059077941926 0.9981687533301715 6.659776342793849 0.9925983524088913 0.2303936150786524 0.005823398662442206 0.0005298808533958193 0.2229965100299555 0.07435921952267822 3.6604055757742635e-11 10.436470791774385 5.661607589463678 LEETVQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEETVQAK 8 0 P31146;H3BRY3 P31146 CORO1A Coronin-1A;Coronin 0 8303720.0 539820.0 3566600.0 4197300.0 False True 739406.0420869759 3409015.818831011 3205984.18610696 1.0 4.610478715063043 4.3358912473288145 19.496007307052178 -10.185128535414966 4.732427674180467 0.9995164958848644 4.473184981214755 0.9953340966124548 0.11209986434997692 0.000571935086114139 9.84800920091821e-05 0.10855223268519613 0.03618007563579534 6.529372782951674e-11 10.185128535414966 3.47366848532989 LEFEK(ub)VYFPYLLISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEFEKVYFPYLLISK 15 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y705;M0QXE6 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 42008800.0 3280300.0 5939500.0 32789000.0 True False 4976454.92205288 4879549.819474685 26308239.77807078 1.0 0.9805272821524484 5.286542366029942 22.24668694462194 -6.90587989206351 0.9233172360846379 0.8486889068264838 5.7966704871853825 0.9892720676853517 0.20977201496400613 0.10720674312787688 0.15400544871654162 0.16831840243880497 0.45239390931528717 1.241995744883327e-07 6.90587989206351 4.947981580358899 up LEFEK(ub)VYFPYLLISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEFEKVYFPYLLISK 15 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y705;M0QXE6 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 49351000.0 3280300.0 3556700.0 42514000.0 True False 4246413.014379919 3358766.5184094277 34776888.230477616 1.0 0.790965576602042 8.189709317654751 22.017813266714388 -6.9004001484727056 0.9587530315342956 0.6957557758456135 8.972623662455817 0.9867638203541051 0.3957200220880926 0.111110722650954 0.1757712207249185 0.3093320191795994 0.8064405467364208 1.257766002457411e-07 6.9004001484727056 8.276867886610203 up LEFLHK(ub)TPVEEVPAAIAPFQGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEFLHKTPVEEVPAAIAPFQGR 22 1 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 1 13756700.0 2700800.0 3847000.0 7208900.0 True False 2615064.582343175 5383127.161839975 5320672.8276356775 1.0 2.0585063933742447 2.0346238726036345 21.318415145423813 -10.421754689542915 5.97794441147919 0.999634364850844 2.04656513298894 0.999609591167248 0.009749998276570745 4.7527702325938984e-05 4.59731160420514e-06 0.009443451964091026 0.003146798412558931 3.786564077135768e-11 10.421754689542915 1.046930768138096 LEGDLTGPSVGVEVPDVELECPDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEGDLTGPSVGVEVPDVELECPDAK 25 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 10920300.0 7429000.0 1232900.0 2258400.0 False True 6177542.660502252 1226258.1229885118 2730620.9983382085 1.0 0.19850257462873003 0.44202381892028914 22.558601637789206 -10.17643154656745 5.286946582309658 1.0000300731115053 0.32026319678823806 0.9121909713220249 0.09941713167452595 3.524239995614537e-05 5.489581544014972e-06 0.09626446938222122 0.032086741275137734 6.661445106240817e-11 10.17643154656745 -0.6797668763232672 LEGELQAPDLELSLPAIHVEGLDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEGELQAPDLELSLPAIHVEGLDIK 25 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 89925000.0 16048000.0 51339000.0 22538000.0 False True 24345989.265952703 42177154.336562164 18083354.421243683 1.0 1.7324066759343366 0.7427652342939636 24.537180787948063 -6.708452146647677 1.8005643552349653 1.4509708358931526 0.7451774519857167 0.4578305697943248 0.30870714188398857 0.3781892889263581 2.389068629397225 0.13648392540222215 0.3474062029399144 1.9568063695366285e-07 6.708452146647677 -0.7057933839074358 LEGELQAPDLELSLPAIHVEGLDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEGELQAPDLELSLPAIHVEGLDIK 25 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 42273200.0 16048000.0 7202200.0 19023000.0 False True 20774452.35337285 6801391.238757384 15561009.192463059 1.0 0.3273920834622213 0.7490454587091265 24.308307110040513 -10.596401317082533 6.019015694471583 1.0017185788723817 0.5382187710861038 0.6152647876254682 0.17213926961286685 0.003982381862055889 0.00026703381363932916 0.167198274619801 0.05555771036991183 2.5327870845086158e-11 10.596401317082533 -0.46349980778627786 LEGENDLLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEGENDLLKR 10 1 Q13137-5;Q13137-2;Q13137;Q13137-3;Q13137-4 Q13137-5 CALCOCO2 Calcium-binding and coiled-coil domain-containing protein 2 1 14845800.0 4705900.0 4500900.0 5639000.0 True False 6169480.472000429 3829383.2643707898 5055530.373107517 1.0 0.6206978499648492 0.8194418308075593 22.55671757538833 -10.033978511789593 4.877481364865714 1.0000053180217958 0.7200698403828837 0.7256627955573374 0.08113689043276578 4.796457207935407e-06 9.498746263859604e-07 0.07856198199713454 0.02618681878213732 9.247439276867305e-11 10.033978511789593 -0.27993547763891213 LEGENDLLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEGENDLLKR 10 1 Q13137-5;Q13137-2;Q13137;Q13137-3;Q13137-4 Q13137-5 CALCOCO2 Calcium-binding and coiled-coil domain-containing protein 2 1 21847400.0 7220500.0 6865900.0 7761000.0 True False 6991289.17980188 9607489.675195491 5728161.274990708 1.0 1.3742085941677138 0.8193283281057232 22.73712707954808 -6.725031030361282 1.7412347355033932 1.2264316662280723 0.8199393725927977 0.5361442368704996 0.1573790576612503 0.34562833345100447 2.050517244323308 0.07169345938636297 0.17891969899727353 1.8835145074812288e-07 6.725031030361282 -0.4064922936352746 LEGENDLLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEGENDLLKR 10 1 Q13137-5;Q13137-2;Q13137;Q13137-3;Q13137-4 Q13137-5 CALCOCO2 Calcium-binding and coiled-coil domain-containing protein 2 1 14388700.0 4705900.0 4678300.0 5004500.0 True False 6445798.40216573 4471597.236930723 3822540.170912795 1.0 0.6937227877664165 0.5930281917641818 22.61992763691122 -13.999999999999998 0.15549975406602165 2.4949223354326477 0.4889553238218995 0.9995489325163143 0.003675663149100649 11.98268919567135 0.12444797185978242 5.405707851564988 0.0943463268220275 1.0000000000000041e-14 13.999999999999998 -2.0059670116107484 LEGENDLLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEGENDLLKR 10 1 Q13137-5;Q13137-2;Q13137;Q13137-3;Q13137-4 Q13137-5 CALCOCO2 Calcium-binding and coiled-coil domain-containing protein 2 1 19629200.0 7220500.0 8767200.0 3641500.0 True False 6004165.672386126 8719969.353447061 4402920.813606348 1.0 1.4523199107498383 0.7333110133612578 22.517532354982357 -6.736669896540442 1.699035955532499 1.2701631374701023 0.7332000560851323 0.589845056018753 0.19006600263367132 0.32387096053945164 1.834425067045748 0.08854860732563069 0.21807731951752402 1.833707678065601e-07 6.736669896540442 -0.5369630813849701 LEGENDLLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEGENDLLKR 10 1 Q13137-5;Q13137-2;Q13137;Q13137-3;Q13137-4 Q13137-5 CALCOCO2 Calcium-binding and coiled-coil domain-containing protein 2 1 40961400.0 12916000.0 21079000.0 6966400.0 True False 16720016.612422965 19905935.120069794 5698586.681300251 1.0 1.1905451759706802 0.34082422364737386 23.995072945042313 -6.847819224162 1.245540075090918 1.1015213016703673 0.308251131430465 0.937083079536003 0.0913176313357605 0.15986435349225842 0.47834756562842207 0.05740054743115217 0.1326587093402482 1.4196483298194215e-07 6.847819224162 -0.7932701702399023 down LEGFHTQISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEGFHTQISK 10 0 Q06323;Q06323-3;Q06323-2;H0YLU2;H0YKK6 Q06323 PSME1 Proteasome activator complex subunit 1 0 11463300.0 2889200.0 4116700.0 4457400.0 False True 3787769.1790525992 3502504.406770917 3996191.006399975 1.0 0.9246879208323268 1.0550249546619699 21.852916987146752 -6.750029023370049 1.6496490167026037 0.9557167959812048 1.055285700421865 0.6491010376436124 0.03164680229683591 0.30001047759479327 1.6063222865553282 0.015154140479878352 0.03679031213256788 1.7781605737677193e-07 6.750029023370049 0.09956890444066013 LEGFHTQISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEGFHTQISK 10 0 Q06323;Q06323-3;Q06323-2;H0YLU2;H0YKK6 Q06323 PSME1 Proteasome activator complex subunit 1 0 9228400.0 2370400.0 1540200.0 5317800.0 False True 2295152.9494913574 2155209.8920368957 3924908.649419612 1.0 0.9390266964624404 1.7100858791521647 21.13015886767791 -6.887777517186329 1.0354764401479868 0.9563356241641898 1.7735781356588405 0.9794358808274336 0.05019004386891708 0.12096341692565042 0.2325475829164072 0.0370364086684553 0.09162060882216655 1.2948590092074954e-07 6.887777517186329 0.8172425114946507 LEGFHTQISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEGFHTQISK 10 0 Q06323;Q06323-3;Q06323-2;H0YLU2;H0YKK6 Q06323 PSME1 Proteasome activator complex subunit 1 0 23998300.0 2444400.0 18405000.0 3148900.0 False True 3708333.509577193 15120483.951078665 2526518.5347881033 1.0 4.077433680662296 0.6813083365514676 21.822339568135565 -6.668099880620348 1.9441550440826287 2.967497844598426 0.6951511045389904 0.27067404046332133 1.3077983858365636 0.46547211435605035 3.390053028954171 0.5419069960978441 1.4514119730784523 2.147336565084529e-07 6.668099880620348 -2.2723467400594357 LEGFHTQISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEGFHTQISK 10 0 Q06323;Q06323-3;Q06323-2;H0YLU2;H0YKK6 Q06323 PSME1 Proteasome activator complex subunit 1 0 10483800.0 2889200.0 3499700.0 4094900.0 False True 3957415.3176942156 3345071.682039724 3127768.95711276 1.0 0.8452667747768075 0.7903565094944727 21.916127048669644 -13.999999996452006 0.14432161498747037 1.7424389338032413 0.7258144771915015 0.9995862769838715 0.0018054218014642517 11.940952776402362 0.11932246709354102 2.4913010411786303 0.05788383649416347 1.0000000081695579e-14 13.999999996452006 -1.0166244566117397 LEGFHTQISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEGFHTQISK 10 0 Q06323;Q06323-3;Q06323-2;H0YLU2;H0YKK6 Q06323 PSME1 Proteasome activator complex subunit 1 0 5454170.0 2370400.0 2213500.0 870270.0 False True 1971092.6265250393 2201575.436154652 1052239.4333261573 1.0 1.116931496028142 0.5338356093296412 20.910564143112186 -6.8545401701842845 1.2128809412508244 1.062736368482985 0.5083887420813764 0.9466656502645592 0.05816930096212516 0.15253469464248479 0.42951286084736057 0.03747839959840675 0.08702311105683547 1.397847615053939e-07 6.8545401701842845 -0.5543476264016085 LEGFHTQISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEGFHTQISK 10 0 Q06323;Q06323-3;Q06323-2;H0YLU2;H0YKK6 Q06323 PSME1 Proteasome activator complex subunit 1 0 8381200.0 2444400.0 2814000.0 3122800.0 False True 3164323.9863275546 2657398.426295195 2554482.442633845 1.0 0.8397997290344827 0.8072758837815851 21.593465890228014 -13.999999999999696 0.22413784821488716 1.9846280895252153 0.7905538880244426 0.9995023688846331 0.0018791448598090455 13.115489511565022 0.14994709083175034 5.728531145937744 0.017520722074842995 1.0000000000006994e-14 13.999999999999696 -1.1940742015007726 LEGHK(ub)EGIVQTEQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEGHKEGIVQTEQIR 15 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2;A0A2R8Y640 A0A3B3IRP5 CDC73 Parafibromin 1 18622900.0 4350400.0 8308000.0 5964500.0 True False 5703416.529333524 7068478.7843303615 5347350.755524 1.0 1.2393411471836429 0.9375697405268886 22.443394968130356 -6.695319525889585 1.8472671971558372 1.1492928289506328 0.9385326171111749 0.39557569334560405 0.10111721073203551 0.4053162387710637 2.685461251372987 0.04372216900861327 0.11310839330789804 2.016881925938277e-07 6.695319525889585 -0.21076021183945792 LEGHK(ub)EGIVQTEQIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEGHKEGIVQTEQIR 15 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2;A0A2R8Y640 A0A3B3IRP5 CDC73 Parafibromin 1 33563200.0 8109900.0 8934400.0 16518900.0 True False 7852455.663634816 12501952.512280492 12192104.533622472 1.0 1.5921073671485684 1.5526486306805685 22.9047124615109 -10.181656006576048 4.891652222289369 0.9999431661806638 1.5723779989159847 0.9964482975598911 0.01610896171189961 9.986145172285143e-06 1.6706233071920557e-06 0.01559897731082144 0.005199145035530794 6.581789574704691e-11 10.181656006576048 0.5724348327353209 LEGHK(ub)EGIVQTEQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEGHKEGIVQTEQIR 15 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2;A0A2R8Y640 A0A3B3IRP5 CDC73 Parafibromin 1 51737300.0 17617400.0 9249900.0 24870000.0 True False 26726883.80446133 7599183.075201427 19954433.599091783 1.0 0.28432731368155045 0.7466053186402872 24.671788301944904 -10.629937030964374 6.704833997649472 1.0015999750033036 0.5154663162006403 0.5942886192106891 0.1887242052434495 0.004525816922398343 0.00024979495873747945 0.18322279960553609 0.060910475327842474 2.344568733361333e-11 10.629937030964374 -0.48613365880266324 LEGHK(ub)EGIVQTEQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEGHKEGIVQTEQIR 15 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2;A0A2R8Y640 A0A3B3IRP5 CDC73 Parafibromin 1 18038700.0 4350400.0 8082200.0 5606100.0 True False 5958860.445139452 7725101.679738689 4282054.641253715 1.0 1.2964058733813664 0.718602941061746 22.506605029653247 -6.767271949029918 1.584936258715788 1.1706041137493428 0.7156864625290771 0.7199889025808144 0.1248362089077112 0.27087115988291954 1.342439619095771 0.06209996585512387 0.14819433682821764 1.7089448629983075e-07 6.767271949029918 -0.45491765122026573 LEGHK(ub)EGIVQTEQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEGHKEGIVQTEQIR 15 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2;A0A2R8Y640 A0A3B3IRP5 CDC73 Parafibromin 1 31512000.0 8109900.0 16100700.0 7301400.0 True False 6743741.179486764 16013962.333361262 8828088.98214072 1.0 2.3746407086429753 1.3090788550714496 22.685117736945177 -10.068764559733404 5.91408823765362 0.9999973828346421 1.8418597818572688 0.4542270189543096 0.4350138051042806 1.5011630321321112e-05 2.3634363524161886e-06 0.4212016168528391 0.1404001018782372 8.535627230999774e-11 10.068764559733404 0.8418623990226267 LEGHK(ub)EGIVQTEQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEGHKEGIVQTEQIR 15 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2;A0A2R8Y640 A0A3B3IRP5 CDC73 Parafibromin 1 66252800.0 17617400.0 8765400.0 39870000.0 True False 22806071.590871826 8277597.784594138 32614069.100746617 1.0 0.36295588004324525 1.4300608051147423 24.442914624037353 -6.745004113266592 1.6683358321989201 0.623177319693729 1.4314003763518233 0.6272154908916803 0.2676496964345627 0.30883188382475973 1.68957931019642 0.126820683803752 0.30951842938609697 1.798853877839787e-07 6.745004113266592 0.8082230566580942 LEGMLSQSVSSQYNMAGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEGMLSQSVSSQYNMAGVR 19 0 P54105;E9PMI6;J3KN38 P54105 CLNS1A Methylosome subunit pICln 0 11590800.0 4561000.0 1363700.0 5666100.0 False True 4416213.551565173 1908232.5216015524 4181978.430643585 1.0 0.4320969761358677 0.9469601915336338 22.074378506461745 -10.4914142394717 9.033026567871927 1.0000079059294718 0.6895285838347517 0.326526667515764 0.21019202750886565 3.3467043841170586e-05 1.884206391460311e-06 0.2035227328846902 0.06783918517061734 3.225416182314999e-11 10.4914142394717 -0.31047932209472007 LEGMLSQSVSSQYNMAGVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEGMLSQSVSSQYNMAGVR 19 0 P54105;E9PMI6;J3KN38 P54105 CLNS1A Methylosome subunit pICln 0 6087600.0 1521900.0 2007200.0 2558500.0 False True 2084587.557801063 1918515.2670772176 1954234.9939615133 1.0 0.9203332620391212 0.9374684151060305 20.991330539480785 -10.000144376030601 4.710459138778774 1.000001387028603 0.9289008385693709 0.9582563623761287 0.006995396957397413 1.0189588059930459e-07 2.1631077241883964e-08 0.0067733961424705025 0.0022577546581184316 9.996676171555735e-11 10.000144376030601 -0.0711005484592322 LEGMLSQSVSSQYNMAGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEGMLSQSVSSQYNMAGVR 19 0 P54105;E9PMI6;J3KN38 P54105 CLNS1A Methylosome subunit pICln 0 8297100.0 4561000.0 1941400.0 1794700.0 False True 3792673.586559529 1930941.292862273 2169963.472244769 1.0 0.5091240384369327 0.5721461187523973 21.85478378189602 -10.344221454272438 5.7648164716144015 1.0000761578834607 0.5406350785950008 0.9860798731316286 0.025728656550270464 2.5187843105257668e-05 2.865267832221515e-06 0.024915768942253003 0.008303888194956484 4.526666984597831e-11 10.344221454272438 -0.4594410792884599 LEGNTVGVEAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEGNTVGVEAAR 12 0 P46060;B0QYT5;B0QYT4 P46060 RANGAP1 Ran GTPase-activating protein 1 0 5616680.0 681980.0 2845900.0 2088800.0 False True 894082.3843037136 2421302.8132313145 1872671.0131844282 1.0 2.7081428464972586 2.0945172906440965 19.77004824762431 -10.228600151136739 5.340683295551962 0.999893656674083 2.401330068570849 0.87427153898413 0.25051158416270763 0.0003172461309138965 4.5823067352623646e-05 0.24257478431534488 0.08085226612441349 5.907447202849547e-11 10.228600151136739 1.4014364118967662 LEGNTVGVEAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEGNTVGVEAAR 12 0 P46060;B0QYT5;B0QYT4 P46060 RANGAP1 Ran GTPase-activating protein 1 0 6802360.0 2071800.0 469960.0 4260600.0 False True 2006031.843045984 657617.4788090246 3144621.044739782 1.0 0.32782005983040124 1.5675828156171987 20.935913076291172 -6.759488961656405 1.6146879498304363 0.6093071438008653 1.571951389667953 0.6887649588012623 0.28269740156466067 0.28377720968091297 1.4581445293607962 0.13815450795906803 0.33213585065978196 1.7398469186877054e-07 6.759488961656405 0.9626442458670876 LEGNTVGVEAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEGNTVGVEAAR 12 0 P46060;B0QYT5;B0QYT4 P46060 RANGAP1 Ran GTPase-activating protein 1 0 3125580.0 681980.0 2443600.0 0.0 False True 934126.4358165232 2335633.672095402 0.0 1.0 2.5003399781249276 0.0 19.8332583091472 -6.74541545751881 1.6747089915463622 1.8882791697184733 1.7816248206317458e-12 0.6236141379681914 0.630404586119219 0.30928203011543054 1.7065373984110417 0.2979732328593479 0.7246884203376328 1.797150890761243e-07 6.74541545751881 -1.8882791697166916 LEGQAQAEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEGQAQAEAK 10 0 B5MCF9;O00541-2;O00541;B3KXD6;H7BYY8 B5MCF9 PES1 Pescadillo homolog 0 4624460.0 512160.0 1883700.0 2228600.0 False True 671446.719764495 1602659.302605092 1998005.850240722 1.0 2.3868748709759324 2.9756729632121934 19.356913398763815 -9.520045039484167 0.24772956044328728 4.299301473133033e-17 3.343934056007537 0.9991094466728161 0.024715563246570517 0.9254470211526841 0.0996521251999928 0.9811175889829623 0.2609241927226144 3.019638545769068e-10 9.520045039484167 3.343934056007537 LEGTK(ub)ELLSSDMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEGTKELLSSDMK 13 1 Q8IUF8-4;Q8IUF8;Q8IUF8-3 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 1 7502500.0 2709300.0 3202500.0 1590700.0 True False 3551918.5368985217 2724699.483247226 1426109.6230718473 1.0 0.7671064116313856 0.40150403458213973 21.760167063241855 -6.96448999159467 0.3666993983631594 1.029188446165448 0.12676162348213704 0.9999022434283368 0.0024354956985810344 0.07813444399701247 0.015472734192450415 0.004844475569161005 0.03110648058386962 1.0852005580138541e-07 6.96448999159467 -0.9024268226833109 down LEGTK(ub)ELLSSDMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEGTKELLSSDMK 13 1 Q8IUF8-4;Q8IUF8;Q8IUF8-3 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 1 9628600.0 2705500.0 3636100.0 3287000.0 True False 2619615.383415824 5088013.692011009 2426036.0921137026 1.0 1.9422750851984 0.9261039263520795 21.32092357758644 -6.663124395812209 1.9620014066740972 1.6049641751391117 0.9303281941216799 0.24894207616412056 0.4009014283682084 0.477043876490293 3.5333941127003836 0.16490553948665282 0.44453345189417837 2.1720789369631424e-07 6.663124395812209 -0.6746359810174318 LEGTK(ub)ELLSSDMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEGTKELLSSDMK 13 1 Q8IUF8-4;Q8IUF8;Q8IUF8-3 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 1 7132300.0 2705500.0 2413200.0 2013600.0 True False 2249743.1239721123 2400199.6126173045 2434634.4501655246 1.0 1.0668771856848922 1.0821833053842036 21.101328853020718 -13.999999999531525 0.20718433518421406 0.617631213564885 1.0914485757142882 0.9994885989817219 0.0008069718369919272 12.681884440991933 0.14428597243952362 1.971320931083433 0.009248504876888008 1.0000000010787037e-14 13.999999999531525 0.4738173621494032 LEGVLAEVAQHYQDTLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEGVLAEVAQHYQDTLIR 18 0 P46940;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 6131300.0 2714800.0 1128000.0 2288500.0 False True 2628620.160006388 1578416.2824422887 1689073.1964716176 1.0 0.6004733230222402 0.6425702816140285 21.325874254503344 -10.167207231299946 8.042587332117014 1.0000000758983523 0.621521802668883 0.9908067310162681 0.017186011378825607 2.3400456523419673e-08 2.404804894725603e-09 0.01664028743588169 0.005546761321493561 6.804445950327499e-11 10.167207231299946 -0.37847827322946925 LEGWEVFAK(ub)PK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEGWEVFAKPK 11 1 Q86Y39 Q86Y39 NDUFA11 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 1 32119900.0 8529900.0 10700000.0 12890000.0 True False 12940481.919220475 8790501.400518423 10342285.8501123 1.0 0.6793024753940505 0.799219527887205 23.62538801025317 -10.182361774240189 5.484389533913954 1.0000085498672022 0.7392610019572796 0.8630812689150362 0.04895593167790997 5.118103696011173e-06 7.630031119311273e-07 0.04740293114181021 0.015800459007201208 6.571102259886458e-11 10.182361774240189 -0.2607475479099226 LEGWEVFAK(ub)PK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEGWEVFAKPK 11 1 Q86Y39 Q86Y39 NDUFA11 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 1 28310100.0 8529900.0 7852200.0 11928000.0 True False 11042123.699466305 7415218.167361456 9757226.39161539 1.0 0.6715391322522364 0.8836367583970268 23.39651433234562 -10.124808809110437 4.840680356673836 1.0000129014200714 0.7775879453232669 0.5945126352955972 0.08658849328975952 1.2056824410084603e-05 2.1797644222095972e-06 0.08384381007956491 0.027946316039699614 7.502244104064698e-11 10.124808809110437 -0.22242495609680446 LEHAK(ub)SVASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEHAKSVASR 10 1 P04844;P04844-2;Q5JYR4;Q5JYR7 P04844;Q5JYR7 RPN2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 1 6804170.0 675870.0 1002600.0 5125700.0 True False 886072.1151343905 853015.9881041907 4595341.733186241 1.0 0.9626936380621951 5.186193826322213 19.757064595240653 -6.90490608513793 0.929715569530115 0.8472460204715216 5.676499954926731 0.9888533406784229 0.2092806738385697 0.1078842376959478 0.15774762863389716 0.16713737602221548 0.4466149829456724 1.244783763375174e-07 6.90490608513793 4.82925393445521 up LEHAK(ub)SVASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEHAKSVASR 10 1 P04844;P04844-2;Q5JYR4;Q5JYR7 P04844;Q5JYR7 RPN2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 1 18467820.0 448520.0 2263300.0 15756000.0 True False 434281.97810743545 3167047.4929535757 11629030.930131888 1.0 7.292606307900005 26.77760422113354 18.728272559315883 -6.950737176820953 0.5506952107201503 0.7316320106800506 34.255040757550034 0.9992578446524437 0.29894417347698 0.0831911557087621 0.03474828036697566 0.3241777491074116 1.6166573341309085 1.1201155417813057e-07 6.950737176820953 33.52340874686998 LEHAK(ub)SVASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEHAKSVASR 10 1 P04844;P04844-2;Q5JYR4;Q5JYR7 P04844;Q5JYR7 RPN2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 1 7032880.0 675870.0 468510.0 5888500.0 True False 925757.4036999828 447809.6790446132 4497757.577464282 1.0 0.4837224927987055 4.858462443279475 19.820274656763544 -6.877468336899535 1.0938729689959676 0.6896078650020282 5.153768554230802 0.9715829846524621 0.3290548818024178 0.12989381003431386 0.28606773326599344 0.23223690806058805 0.558145953423432 1.325963786256005e-07 6.877468336899535 4.464160689228774 up LEHLEK(ub)QVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEHLEKQVR 9 1 A0A5F9ZHY7;Q8WY22 A0A5F9ZHY7 BRI3BP BRI3-binding protein 1 4929400.0 1886300.0 1299500.0 1743600.0 True False 2472957.566955186 1105619.665411327 1563188.9977922116 1.0 0.44708396140117135 0.6321131501325672 21.237806054313435 -10.079535366051639 5.57139685988999 1.0000034265960196 0.5395985557667324 0.8919535196428643 0.07553784998599551 3.2150642196857497e-06 5.313032793198882e-07 0.07313975244773542 0.02437973625026873 8.326541174157444e-11 10.079535366051639 -0.46040487082928716 LEHLEK(ub)QVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEHLEKQVR 9 1 A0A5F9ZHY7;Q8WY22 A0A5F9ZHY7 BRI3BP BRI3-binding protein 1 5072700.0 1310400.0 1646800.0 2115500.0 True False 1268802.069276694 2304375.8279485493 1561387.0863603738 1.0 1.8161822744048683 1.2305994167005685 20.275035598357636 -10.033695448835687 5.400591434317165 0.9999968362090174 1.5233908455533511 0.5157756852009552 0.23906320058494526 9.106702979437786e-06 1.6292692843925343e-06 0.23147334865289754 0.07715731621272333 9.253468505466386e-11 10.033695448835687 0.5233940093443338 LEHLEK(ub)QVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEHLEKQVR 9 1 A0A5F9ZHY7;Q8WY22 A0A5F9ZHY7 BRI3BP BRI3-binding protein 1 6694400.0 1078300.0 2854000.0 2762100.0 True False 1635859.934289433 2344681.401596224 2216169.7243285617 1.0 1.433302052607995 1.3547429568236216 20.641617796358908 -10.034227235033123 4.813962943326186 0.9999911625598015 1.394022504723336 0.9710496633970105 0.03207161658028482 22179235.39975227 1.7422365052448814 2172.6656402247663 0.010978967406513815 9.242144725162833e-11 10.034227235033123 0.39403134216353464 LEHLEK(ub)QVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEHLEKQVR 9 1 A0A5F9ZHY7;Q8WY22 A0A5F9ZHY7 BRI3BP BRI3-binding protein 1 4789580.0 1310400.0 2011800.0 1467380.0 True False 1089655.660562948 2000962.0340889678 1774202.3736014534 1.0 1.8363250947140606 1.628222967873033 20.055440873791913 -10.19122439315981 4.822784359163627 0.999907928909674 1.7322740312958942 0.9428880276826151 0.08495733753283173 8.411588279396619e-05 1.4106031810950435e-05 0.0822698418374634 0.02741986278241455 6.438365193100968e-11 10.19122439315981 0.7323661023862202 LEHLLQAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEHLLQAKR 9 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 5555100.0 1814700.0 2101600.0 1638800.0 True False 1757093.3418165583 2940779.83969922 1209549.1170538298 1.0 1.6736617057912904 0.6883806843200181 20.7447594027871 -6.722671821233791 1.7496815877513208 1.4086882897697135 0.6896878816343034 0.525004485718363 0.28339278412323227 0.35020454416266694 2.096647577392123 0.12853294808343335 0.3216586257765296 1.8937741265641332e-07 6.722671821233791 -0.7190004081354101 LEHLLQAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEHLLQAKR 9 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 7185000.0 1814700.0 3804000.0 1566300.0 True False 1509003.4548409516 3783507.096965119 1893806.0882470477 1.0 2.5072885584373292 1.2550044747555957 20.525164678221376 -6.60050750668895 2.188548808528676 2.0133318212970512 1.2590593623891264 0.022066512935015825 0.6514077243320091 0.639260160735214 5.78728793912869 0.2469869845925701 0.724626383134937 2.50895281236794e-07 6.60050750668895 -0.7542724589079248 LEHPVLHVSWNDAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEHPVLHVSWNDAR 14 0 J3KQJ1;Q8NBJ7;C9J660;C9JL30;Q8NBJ7-3;A8MXB9;F8WA42;A0A494C1B1;Q8NBJ7-2;H7C3B2 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 52508300.0 17538100.0 17484600.0 17485600.0 False True 22992618.93920198 14875965.83443699 15676357.8457189 1.0 0.6469887520761608 0.6817995760800875 24.45466746760597 -10.562800336650561 6.011965699388795 1.0007895872455432 0.6643941640781241 0.9919953824954754 0.01421145938924151 0.00015073900286337856 1.0961979776003533e-05 0.013790908206875254 0.004586728794986278 2.736526532927778e-11 10.562800336650561 -0.3363954231674191 LEHPVLHVSWNDAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEHPVLHVSWNDAR 14 0 J3KQJ1;Q8NBJ7;C9J660;C9JL30;Q8NBJ7-3;A8MXB9;F8WA42;A0A494C1B1;Q8NBJ7-2;H7C3B2 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 44370700.0 15943200.0 10608500.0 17819000.0 False True 15437091.842866449 14844529.372596653 13151669.341458514 1.0 0.9616143716509906 0.8519525228798818 23.879897656516498 -6.952544348899047 0.5301747317261668 1.001727365653785 0.8068598154944314 0.9993861220808823 0.0015542614356154848 0.08247985691370298 0.0318563041277494 0.0017335634718441365 0.009068657068894296 1.1154642375461509e-07 6.952544348899047 -0.19486755015935364 LEHPVLHVSWNDAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEHPVLHVSWNDAR 14 0 J3KQJ1;Q8NBJ7;C9J660;C9JL30;Q8NBJ7-3;A8MXB9;F8WA42;A0A494C1B1;Q8NBJ7-2;H7C3B2 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 58474100.0 17538100.0 15315000.0 25621000.0 False True 24022409.51933161 14638332.660067558 19569847.48105837 1.0 0.609361548361234 0.8146496489167699 24.51787752912886 -10.125232537084859 4.914143057228341 1.000014476097799 0.7120055986377777 0.7240689138055112 0.08380851610860401 1.329260617669139e-05 2.3662553852132536e-06 0.08115132268615434 0.02704908226264436 7.49492796132974e-11 10.125232537084859 -0.28800887746002124 LEHPVLHVSWNDAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEHPVLHVSWNDAR 14 0 J3KQJ1;Q8NBJ7;C9J660;C9JL30;Q8NBJ7-3;A8MXB9;F8WA42;A0A494C1B1;Q8NBJ7-2;H7C3B2 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 35540000.0 15943200.0 10908300.0 8688500.0 False True 13257477.203515872 10849534.822771972 10505225.17891496 1.0 0.818370995945947 0.7924000183178881 23.660302931950774 -13.999999999999998 0.27396225460927554 2.432185150812413 0.7841050061357062 0.999591904621695 0.0018656440019218885 15.081019892079299 0.16572922549830882 12.05814936565295 0.010576870497435019 1.0000000000000041e-14 13.999999999999998 -1.6480801446767066 LEHSLYKPQK(ub)GLFHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEHSLYKPQKGLFHR 15 2 D6REL5;Q6UWZ7-2;Q6UWZ7;A0A087WZ78;A0A087WWJ9 D6REL5 FAM175A BRCA1-A complex subunit Abraxas 1 44876100.0 5796200.0 14774900.0 24305000.0 True False 8793259.158980258 12138203.658179414 19501106.096740052 1.0 1.3803987166445648 2.21773357797879 23.067966558471497 -6.958128109051054 0.4610642045978551 0.9758508255098611 2.656095980113578 0.9996943288667537 0.008893308902835125 0.08037679397233535 0.023654816893069835 0.01139265838601141 0.06916431414652885 1.101214423202629e-07 6.958128109051054 1.6802451546037167 up LEHSLYKPQK(ub)GLFHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEHSLYKPQKGLFHR 15 2 D6REL5;Q6UWZ7-2;Q6UWZ7;A0A087WZ78;A0A087WWJ9 D6REL5 FAM175A BRCA1-A complex subunit Abraxas 1 46442500.0 5796200.0 16321800.0 24324500.0 True False 7503295.1601831885 15413477.481984707 19897690.59044671 1.0 2.0542277963124134 2.6518603047945297 22.839092880563946 -8.98732204660033 0.1856070568018373 4.137762574368395e-21 3.374181560511115 0.9996683057982162 0.01243734389201213 0.4651851488931067 0.06111443385197745 0.6269550971529008 0.3527524619945206 1.0296223314507053e-09 8.98732204660033 3.374181560511115 LEIK(ub)YIDSADLEPITSQEEPVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEIKYIDSADLEPITSQEEPVR 22 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 1 33915900.0 15063000.0 6792900.0 12060000.0 True False 14584833.31006932 9505340.39450554 8901124.207755173 1.0 0.6517277360957622 0.6103000300736976 23.79796556199301 -13.999999999999998 0.3003799928298211 4.183777829765701 0.6001467880975904 0.9996506779240196 0.0032663251020897443 16.613242829561813 0.1740696728040943 32.88092150455041 0.01494728677444731 1.0000000000000041e-14 13.999999999999998 -3.5836310416681103 LEIK(ub)YIDSADLEPITSQEEPVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEIKYIDSADLEPITSQEEPVR 22 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 1 85337000.0 19157000.0 28868000.0 37312000.0 True False 29062569.564298153 23716279.8532865 29937266.845569417 1.0 0.8160420846758406 1.0300970387128392 24.792658928565086 -6.679234601751503 1.9043694568885436 0.8835298740886017 1.0292822807720035 0.32073266312660575 0.07797846116864755 0.440223665852111 3.0859951442854765 0.03286260591314174 0.08676554218714812 2.0929815416871454e-07 6.679234601751503 0.14575240668340173 LEIK(ub)YIDSADLEPITSQEEPVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEIKYIDSADLEPITSQEEPVR 22 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 1 27526900.0 15063000.0 5837400.0 6626500.0 True False 12525551.904044325 5805952.767566826 8012070.512525739 1.0 0.46352869814001296 0.6396580824465511 23.578370837427286 -10.338090704476551 6.290872868263485 1.000030738649097 0.5515933902932827 0.8962881153038577 0.07190452004359729 3.100160767678034e-05 3.2619020167411015e-06 0.06962601165355446 0.02320708405382409 4.5910211715343763e-11 10.338090704476551 -0.4484373483558143 LEIK(ub)YIDSADLEPITSQEEPVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEIKYIDSADLEPITSQEEPVR 22 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 1 67523000.0 19157000.0 15254000.0 33112000.0 True False 24799114.140924998 14405101.490656322 27085955.75781093 1.0 0.580871615364847 1.092214649438306 24.563785250657535 -6.688885686952562 1.8704972749033115 0.7369540378870241 1.0904169896497042 0.3651273931024639 0.17730296361604825 0.41908637698228224 2.8420201685018567 0.07585679137421723 0.19780536047703792 2.04698336360929e-07 6.688885686952562 0.35346295176268017 LEILQIHTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEILQIHTK 9 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 104606700.0 23773700.0 35729000.0 45104000.0 False True 31167550.924838256 30398372.470551167 40437070.74811875 1.0 0.9753211775881271 1.2974093102674091 24.89354145993821 -6.888406623821929 1.0317352413109917 0.9820270535903071 1.3242650258963873 0.9798596832931744 0.02077149545050879 0.12044658766414386 0.2294619575206859 0.015370768893897909 0.03810719640248411 1.2929846711553585e-07 6.888406623821929 0.3422379723060802 LEILQIHTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEILQIHTK 9 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 76141200.0 27510000.0 17628200.0 31003000.0 False True 26636710.10821268 24667232.189848546 22882384.22993647 1.0 0.9260615177188529 0.8590544454242242 24.666912570807565 -6.9722971819969635 0.1956972841266015 1.0421672673173632 0.7411071810195504 0.999995183308435 0.00012620343700200636 0.07556416449757135 0.006285716817666471 0.0022545319091641144 0.0071930104808801965 1.0658665132041031e-07 6.9722971819969635 -0.3010600862978128 LEILQIHTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEILQIHTK 9 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 69933000.0 13122600.0 41647000.0 15163400.0 False True 19907943.59056524 34214767.4605038 12166347.343645683 1.0 1.7186490058530628 0.6111302901928831 24.246840868448455 -6.731559395190682 1.71747265417506 1.4317312131007336 0.6115952069948818 0.566478136471096 0.3020686246752095 0.33334038229160995 1.9269801341586545 0.13933507678009768 0.3451512728662844 1.8554130411908224e-07 6.731559395190682 -0.8201360061058518 LEILQIHTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEILQIHTK 9 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 82190700.0 23773700.0 39677000.0 18740000.0 False True 32563479.35008545 37923938.94570681 14313997.962414972 1.0 1.164615689189469 0.4395721295174624 24.9567515214611 -6.847037711451161 1.2493619657967476 1.087668318515409 0.412211875631808 0.9358740130895591 0.07859080396732163 0.16074636470262504 0.4843390745125397 0.049259264930788596 0.1137898337067101 1.4222052862355338e-07 6.847037711451161 -0.675456442883601 down LEILQIHTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEILQIHTK 9 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 44379500.0 27510000.0 13630200.0 3239300.0 False True 22875783.899638843 13556771.407217136 3916622.6531690415 1.0 0.5926254359935254 0.17121260938432262 24.44731784624184 -7.659948595487314 0.39267690084170875 1.0468811842960928 5.998403609504849e-21 0.9985379359126072 0.012938127822705786 0.1205328014054692 0.05905717736769637 0.026707172309599715 0.07433332054683907 2.1880205898833072e-08 7.659948595487314 -1.0468811842960928 down LEILQIHTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEILQIHTK 9 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 42930300.0 13122600.0 14219300.0 15588400.0 False True 16987464.385117806 13427983.455230718 12751471.150491044 1.0 0.7904642594567887 0.7506400520646398 24.017967190540904 -13.999999999999998 0.23347783333748356 2.3443834382536988 0.731906972288967 0.9995147332815753 0.002409452065895386 13.40217887156102 0.15297119161731845 8.369028037356742 0.02023443440780985 1.0000000000000041e-14 13.999999999999998 -1.6124764659647317 LEILQIHTK(ub)NMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEILQIHTKNMK 12 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 138504000.0 36908000.0 52247000.0 49349000.0 True False 48386745.41758047 44451951.25721086 44242838.86903403 1.0 0.9186803301934836 0.9143586427897913 25.528108568340013 -13.9999986182304 0.4182913825261484 2.5427268722494043 0.9142092597823415 0.9998620127230156 0.00046270117791206175 29.673687983717244 0.21550733633971308 41.819488601326846 0.0010533443959276792 1.0000031816471445e-14 13.9999986182304 -1.6285176124670628 LEILQIHTK(ub)NMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEILQIHTKNMK 12 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 191359000.0 36908000.0 76048000.0 78403000.0 True False 50553885.001196966 72687947.90289369 59885826.160470806 1.0 1.4378310964859111 1.1845939468164097 25.591318629862904 -10.161685100300266 4.624973352475651 0.9999587085767307 1.311212521654884 0.6681836316598941 0.10338363344728867 4.402441914711881e-05 7.97981700540392e-06 0.10011403438478327 0.03336692421584351 6.891518077331335e-11 10.161685100300266 0.31125381307815325 LEILQIHTKNMK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEILQIHTKNMK 12 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 77384900.0 8742200.0 6287700.0 62355000.0 True False 8464683.646238346 8798411.399922337 46022354.89009739 1.0 1.0394258979580764 5.436984630908143 23.01302472007573 -6.908863054335887 0.9034426561518091 0.8588986799501261 5.9916879547746955 0.9904853958757436 0.2031216375834272 0.10517465106667606 0.14288104132062018 0.1653691704402763 0.45297651089607693 1.233493728309766e-07 6.908863054335887 5.132789274824569 up LEILQIHTKNMK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEILQIHTKNMK 12 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 144950200.0 8742200.0 92867000.0 43341000.0 True False 7269526.645126234 92366707.0383438 52403402.71385774 1.0 12.70601396038213 7.2086402969567445 22.793429995510007 -9.908916329784441 6.0678055886593905 0.9999978583468335 9.957327128672116 0.7797284971942215 2.244293400144031 6.514745470170384e-05 1.1740230216838341e-05 2.1730282567598267 0.7243425802286868 1.2333424233683018e-10 9.908916329784441 8.957329270325282 LEIYVVTAEGLRPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEIYVVTAEGLRPVK 15 1 Q16531;F5GY55;Q16531-2;F5GYG8;F5H198;F5GZY8 Q16531;F5GZY8 DDB1 DNA damage-binding protein 1 0 7239700.0 0.0 2315700.0 4924000.0 False True 0.0 3240371.086215966 3634256.6831663777 0.0 LEIYVVTAEGLRPVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEIYVVTAEGLRPVK 15 1 Q16531;F5GY55;Q16531-2;F5GYG8;F5H198;F5GZY8 Q16531;F5GZY8 DDB1 DNA damage-binding protein 1 0 94340000.0 26245000.0 35637000.0 32458000.0 False True 39815583.76650855 29277298.916848145 26042662.073153198 1.0 0.7353226085680342 0.6540821359263695 25.246829874434024 -13.999999995343904 0.1654276009381167 2.3195584831298905 0.578815557359384 0.999523153973054 0.003225091204319299 12.050276488297628 0.12869448163639413 5.101278021345377 0.06909665466721193 1.0000000107210572e-14 13.999999995343904 -1.7407429257705065 LEIYVVTAEGLRPVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEIYVVTAEGLRPVK 15 1 Q16531;F5GY55;Q16531-2;F5GYG8;F5H198;F5GZY8 Q16531;F5GZY8 DDB1 DNA damage-binding protein 1 0 90166000.0 26245000.0 35961000.0 27960000.0 False True 33974669.86629305 33959738.73774044 22871566.893826794 1.0 0.9995605217471908 0.673194676617539 25.017956196526473 -6.907191839337484 0.9146511268546776 1.0110240939117352 0.633456578695581 0.9898178691894005 0.015534967718755973 0.10630422607943103 0.1490590246077893 0.01254467005341182 0.03399064220096366 1.238249498216e-07 6.907191839337484 -0.37756751521615417 LEK(ub)EEQQTLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEKEEQQTLSR 11 1 O00635 O00635 TRIM38 E3 ubiquitin-protein ligase TRIM38 1 1691270.0 727750.0 0.0 963520.0 True False 704647.9746002095 0.0 711145.2070195916 1.0 0.0 1.0092205365708578 19.426543175726756 -12.04914982981265 18.04932764556156 0.8789748860962753 0.5541492414568983 0.0 0.48749501342318413 0.0 0.0 0.0 0.13998440974986034 8.929973501655918e-13 12.04914982981265 -0.324825644639377 LEK(ub)IFQNAPTDPTQDFSTQVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEKIFQNAPTDPTQDFSTQVAK 22 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 611965800.0 194823100.0 221092700.0 196050000.0 True False 255414970.76958394 188106530.97259477 175764626.6443924 1.0 0.7364741792770254 0.6881531889646122 27.928267848047327 -13.99999999999965 0.2385609806952368 2.7322060308414353 0.6664943701331041 0.9995226038310607 0.0029943205009605317 13.57311869368206 0.1545962472803276 11.191256080484356 0.023812851305759566 1.0000000000008057e-14 13.99999999999965 -2.065711660708331 LEK(ub)IFQNAPTDPTQDFSTQVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEKIFQNAPTDPTQDFSTQVAK 22 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 853832700.0 301744400.0 275289200.0 276799100.0 True False 292165689.1885341 385213613.1742126 204297111.91499552 1.0 1.3184765611735976 0.699250868513732 28.12221152264762 -6.76692093584953 1.5863998762677871 1.1833866910439041 0.6961777836286309 0.7186015407270208 0.13411999085337853 0.2714292434615684 1.3476527813328476 0.06666086768206357 0.1591226897507484 1.7103266550251764e-07 6.76692093584953 -0.48720890741527323 LEK(ub)IFQNAPTDPTQDFSTQVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEKIFQNAPTDPTQDFSTQVAK 22 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 638246000.0 304710000.0 208496000.0 125040000.0 True False 462267347.2849237 171288259.8133169 100325789.193021 1.0 0.3705393876927705 0.21702979841053768 28.78415221906875 -13.999999999999998 0.19819596888070123 4.475353092878138 0.11554267856896024 0.9994869441637089 0.007673172836949369 12.495807496794534 0.14116990225485507 16.822428955332448 0.09907826330054037 1.0000000000000041e-14 13.999999999999998 -4.359810414309178 LEK(ub)IFQNAPTDPTQDFSTQVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEKIFQNAPTDPTQDFSTQVAK 22 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 616324100.0 194823100.0 261411300.0 160089700.0 True False 266854464.96631294 249861284.39443138 122279810.01086584 1.0 0.9363204187944664 0.4582265843904922 27.991477909570218 -6.931297403938416 0.7360638275550583 1.0069316497389273 0.3567526144463667 0.9967871601406866 0.013704932271958006 0.09196971812694633 0.07442055319364103 0.012583622217591007 0.042954769635415266 1.171392923439175e-07 6.931297403938416 -0.6501790352925607 down LEK(ub)IFQNAPTDPTQDFSTQVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEKIFQNAPTDPTQDFSTQVAK 22 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 803883900.0 301744400.0 343829500.0 158310000.0 True False 250913838.14344546 341977222.2386875 191411889.05726266 1.0 1.3629269105643422 0.7628590374829546 27.902616798081898 -6.742979471411796 1.6758861261013291 1.2151954200001065 0.7622816577628784 0.6181755829608762 0.15248040627873413 0.31246504540336556 1.7242618968722496 0.07194698376851237 0.1759706191902134 1.8072595510204827e-07 6.742979471411796 -0.4529137622372281 LEK(ub)IFQNAPTDPTQDFSTQVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEKIFQNAPTDPTQDFSTQVAK 22 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 560936400.0 304710000.0 186836400.0 69390000.0 True False 394453101.73206925 176438790.09760472 56761732.00152512 1.0 0.447299791338566 0.14389982421808994 28.5552785411612 -8.69007915268534 0.300094128674949 1.201686999521902 4.557177242342236e-23 0.9986806224417951 0.012873194993389327 0.2655233919889026 0.0912695658297773 0.15359071576072914 0.09698465857909401 2.041365860008962e-09 8.69007915268534 -1.201686999521902 LEK(ub)IHPTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEKIHPTGK 9 1 P35244 P35244 RPA3 Replication protein A 14 kDa subunit 1 4666700.0 1042000.0 1719800.0 1904900.0 True False 1366072.090742355 1463212.5437278955 1707799.221091066 1.0 1.0711093167365364 1.2501530722020744 20.38160218927147 -6.9553088016830475 0.49715907700120915 0.9963243057933765 1.33262318692275 0.9995547195538184 0.002220850720776031 0.08142145037121863 0.027662685315881744 0.002618613124892815 0.014768272983431537 1.1083864255371072e-07 6.9553088016830475 0.33629888112937356 LEK(ub)IHPTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEKIHPTGK 9 1 P35244 P35244 RPA3 Replication protein A 14 kDa subunit 1 6495400.0 1794600.0 2064100.0 2636700.0 True False 1737631.4053143754 2888305.8941393 1946069.1706955314 1.0 1.662208616456689 1.1199551094344113 20.728690652557137 -10.251308151483597 4.608974748567052 0.9998614629775253 1.3910818629475166 0.4095196790954916 0.22137406724659536 0.0003152473240903983 5.120944282290017e-05 0.21441997338657806 0.07144817297640788 5.6065002843685674e-11 10.251308151483597 0.39122039996999125 LEK(ub)IHPTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEKIHPTGK 9 1 P35244 P35244 RPA3 Replication protein A 14 kDa subunit 1 4787800.0 1042000.0 1097700.0 2648100.0 True False 1427255.5589912005 1049199.9843915217 2022673.319331436 1.0 0.7351171118458333 1.4171766973260789 20.44481225079436 -6.801404758629673 1.4502889695788344 0.8541127788782588 1.4269091661404238 0.8362093199967705 0.11362407058848903 0.21875731122684974 0.9082585295809277 0.06163182794690315 0.14320439872193078 1.5797750165621236e-07 6.801404758629673 0.5727963872621651 LEK(ub)PAKYDDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEKPAKYDDIK 11 2 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 6559000.0 1417300.0 2020800.0 3120900.0 True False 2150147.7185091474 1660172.451417537 2504052.747060936 1.0 0.7721201837093566 1.1645956812665765 21.036004347948136 -6.749288935936783 1.6524256649090625 0.8658906838341106 1.1653361220111804 0.6459312862695139 0.0957534645445051 0.30128464193484983 1.6183573655257015 0.04577971087727596 0.11122607556132066 1.781193345975089e-07 6.749288935936783 0.2994454381770698 LEK(ub)PAKYDDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEKPAKYDDIK 11 2 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 5903700.0 1417300.0 1536900.0 2949500.0 True False 1834722.7891597312 1451370.1639563225 2412721.264425685 1.0 0.7910569228940699 1.315033136711986 20.807130670040586 -6.798521077383471 1.4621984347235177 0.8844995147678851 1.3219838553012002 0.8277280925584615 0.08939029530428431 0.22287932881511996 0.9409574319517222 0.04810015011904944 0.11195282682571656 1.5902995007883486e-07 6.798521077383471 0.4374843405333151 LEK(ub)PAKYDDIKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEKPAKYDDIKK 12 3 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 10800400.0 2983700.0 2707600.0 5109100.0 True False 4526491.037688376 2224407.6254246435 4099284.145601915 1.0 0.49141986737714194 0.905620736122206 22.10996166723248 -9.989237194316564 7.0174986946635 1.0000000243350027 0.6985203017496748 0.41396097780052177 0.16909679657382065 6.435606625286915e-08 9.386909282722709e-09 0.16372728145546403 0.0545757564189524 1.0250919090388515e-10 9.989237194316564 -0.30147972258532785 LEK(ub)PAKYDDIKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEKPAKYDDIKK 12 3 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 9632700.0 2983700.0 2018400.0 4630600.0 True False 3862458.4675198505 1906074.2656838065 3787878.3139683236 1.0 0.493487316876634 0.9806910147568743 21.88108798932493 -10.76718765939104 10.178090797801781 1.0011225956152356 0.7370891658167541 0.2796793566070881 0.19890007676728047 0.005084836306619667 0.00011630964211186688 0.19327282985736582 0.06419472373992113 1.7092765741547295e-11 10.76718765939104 -0.26403342979848154 LEK(ub)SLEHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEKSLEHLR 9 1 Q96F44-3;Q96F44;R4GMV1;Q96F44-2;R4GNB9 Q96F44-3 TRIM11 E3 ubiquitin-protein ligase TRIM11 1 2010790.0 728720.0 545110.0 736960.0 True False 955358.9769345185 463781.7128221378 660706.4486194932 1.0 0.4854528235138214 0.6915792540512014 19.865683403324923 -10.201228759133349 5.438257413881171 1.0000186392867374 0.5885160387824608 0.8416081782400733 0.08415076288648324 1.9018121305293406e-05 2.79341449995708e-06 0.08148231110972072 0.02715954193580722 6.291746857394545e-11 10.201228759133349 -0.41150260050427656 LEK(ub)SLEHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEKSLEHLR 9 1 Q96F44-3;Q96F44;R4GMV1;Q96F44-2;R4GNB9 Q96F44-3 TRIM11 E3 ubiquitin-protein ligase TRIM11 1 3155040.0 587040.0 1314100.0 1253900.0 True False 568404.7365294505 1838826.9829409712 925465.9738063192 1.0 3.235066256077366 1.6281813192778847 19.11655905107781 -6.560826832347453 2.343419886120307 2.539159909287875 1.630830804670524 0.0 0.9756758250389649 0.758864064977064 7.8113078505575935 0.35401484956158485 1.097065711208249 2.7489900483538253e-07 6.560826832347453 -0.908329104617351 LEK(ub)SLEHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEKSLEHLR 9 1 Q96F44-3;Q96F44;R4GMV1;Q96F44-2;R4GNB9 Q96F44-3 TRIM11 E3 ubiquitin-protein ligase TRIM11 1 2129460.0 728720.0 767530.0 633210.0 True False 998147.4769175308 733617.9867177047 483658.8393693053 1.0 0.7349795533053458 0.48455649145448504 19.928893464847814 -6.971811138441682 0.21048394039161306 1.130304267588243 0.08223714751709577 0.9999932731604952 0.0005458140767756141 0.07571932515271768 0.006886408522682025 0.007470283707814122 0.025920931587917174 1.0670600525491392e-07 6.971811138441682 -1.0480671200711473 down LEK(ub)SLEHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEKSLEHLR 9 1 Q96F44-3;Q96F44;R4GMV1;Q96F44-2;R4GNB9 Q96F44-3 TRIM11 E3 ubiquitin-protein ligase TRIM11 1 6187700.0 1657000.0 1427900.0 3102800.0 True False 2145019.164353118 1348436.1097750226 2538122.2374165147 1.0 0.6286359265147526 1.1832631985747066 21.032559106649785 -6.726273871806788 1.7367941642683535 0.775590106259951 1.1827155105207556 0.5418887803278765 0.1561640125858453 0.3432828765117826 2.0268485757488017 0.07130513336645877 0.17769166027422476 1.8781320685231104e-07 6.726273871806788 0.4071254042608047 LEK(ub)VMDDFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEKVMDDFR 9 1 Q9NY27;C9IZ04;F8WDK3 Q9NY27 PPP4R2 Serine/threonine-protein phosphatase 4 regulatory subunit 2 1 13429300.0 2562900.0 4595200.0 6271200.0 True False 3888106.673087626 3775150.657538525 5031694.571235391 1.0 0.9709483239410711 1.2941246201045247 21.89063637021832 -6.8849596278781915 1.051776127572094 0.9804796556223984 1.3193202733881633 0.9774697415556739 0.021911990366795402 0.1233264624034168 0.2465197521839464 0.015970158877031747 0.03915467313317988 1.3032879267873085e-07 6.8849596278781915 0.3388406177657649 LEKEEAK(ub)QIQNLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEKEEAKQIQNLQK 14 2 P10644;P10644-2;K7EPB2;K7EIE5;K7EID3;K7EJ40;K7EK41;K7EMU2;K7EMZ6 P10644 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 1 11693300.0 3292000.0 4827000.0 3574300.0 True False 4994204.677437454 3965584.1364768655 2867838.0383286565 1.0 0.7940371675979492 0.5742331809676962 22.251823517757508 -6.970298846104679 0.2509440897895225 1.0689503367400437 0.29287448980601516 0.9999846200578616 0.0006817646017800961 0.07620585265908643 0.008682422266813155 0.004871250916015505 0.021033787853130974 1.0707822265165676e-07 6.970298846104679 -0.7760758469340285 LEKPAK(ub)YDDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEKPAKYDDIK 11 2 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 3754060.0 1324400.0 1638700.0 790960.0 True False 1736301.2255078454 1394212.3476025718 709119.046624069 1.0 0.8029783813547577 0.4084078477895798 20.727585827502597 -6.960018718903377 0.43517071196718476 1.014839970615974 0.1812852407180071 0.9997708904514206 0.003722996755941502 0.07969444397441004 0.0211066835455738 0.005172702991053082 0.032724154996031304 1.0964309369033382e-07 6.960018718903377 -0.833554729897967 down LEKPAK(ub)YDDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEKPAKYDDIK 11 2 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 8543800.0 1759200.0 3159900.0 3624700.0 True False 1703355.1589373944 4421664.548660806 2675282.331330861 1.0 2.59585590559938 1.570595725321186 20.699947845571597 -10.509340225571698 5.093292009723159 0.9965672237894487 2.083225815460304 0.5981292032275721 0.41856071587931826 0.01634062945571032 0.0015741655516950971 0.40589024835094484 0.13508989016476058 3.0949937363263645e-11 10.509340225571698 1.086658591670855 LEKPAK(ub)YDDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEKPAKYDDIK 11 2 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 21455900.0 2723700.0 2910200.0 15822000.0 True False 4132052.029142282 2390852.072503615 12694774.76497105 1.0 0.5786113184542597 3.0722688570807253 21.97842698947898 -6.86342672399253 1.1683910381692317 0.7689648517799735 3.201117619950001 0.9576660030402231 0.2242416017464587 0.1433082651674422 0.36983204926976887 0.1494760625081496 0.35035852222218933 1.3695354427285405e-07 6.86342672399253 2.4321527681700275 up LEKPAK(ub)YDDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEKPAKYDDIK 11 2 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 4268500.0 1324400.0 1658500.0 1285600.0 True False 1814066.4705642476 1585221.9860739154 981967.7577631106 1.0 0.8738500004252037 0.5413074844262344 20.79079588902549 -6.95431630491456 0.5092628336372905 1.0061574632558552 0.3944293061214924 0.9994979015283958 0.00433532332370313 0.08179751912760173 0.02913778553042707 0.004999820663762194 0.027444186854996954 1.1109223267493786e-07 6.95431630491456 -0.6117281571343628 LEKPAK(ub)YDDIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEKPAKYDDIK 11 2 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 6445200.0 1759200.0 2800200.0 1885800.0 True False 1462852.7457740686 2785114.7668038164 2280112.0610459577 1.0 1.9038927703759223 1.558675039324916 20.480353121005873 -10.37877305920343 5.452602500803841 0.9997002339510891 1.7312839048504283 0.8567966488810954 0.14093454853941895 0.0005137801189878089 5.85358325439964e-05 0.13651326773511352 0.045486429949864536 4.1804876116772445e-11 10.37877305920343 0.7315836708993392 LEKPAK(ub)YDDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEKPAKYDDIK 11 2 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 15906200.0 2723700.0 3149500.0 10033000.0 True False 3525883.342153639 2974227.556366995 8207096.947273409 1.0 0.8435411123245818 2.327671153822249 21.74955331157143 -6.880845345463935 1.075043786020807 0.9018954294119697 2.4345831142122414 0.974362188721344 0.106609651950285 0.12688524230106635 0.26776745038342464 0.07633054766134084 0.18499423563579057 1.3156932740350424e-07 6.880845345463935 1.5326876848002717 up LEKPAKYDDIK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEKPAKYDDIKK 12 3 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 111128000.0 18625000.0 28561000.0 63942000.0 True False 24110429.653637193 26971555.242863223 52305212.10032455 1.0 1.1186675488710924 2.169401908291336 24.523154024552582 -6.928258041249621 0.7609507921827096 0.9829472049108459 2.3758483875690217 0.9961848350610651 0.03246035355563663 0.09355203321762677 0.08218418383635068 0.02927235933195149 0.0959997472932897 1.179619542361318e-07 6.928258041249621 1.3929011826581759 up LELEENQMK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LELEENQMKR 10 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 3470700.0 1038300.0 1110100.0 1322300.0 True False 1361221.3549115018 944477.4071359092 1185481.080397247 1.0 0.6938455701771689 0.8708951531797853 20.3764702589922 -10.20514897262738 5.266033588357154 1.0000141907487632 0.7823703623892316 0.6682790764964264 0.0722801895883749 1.2043104524242842e-05 1.8177008997940842e-06 0.06998955378755939 0.023328330878009618 6.235209173088877e-11 10.20514897262738 -0.21764382835953155 LELEENQMK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LELEENQMKR 10 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 5636500.0 1744900.0 1030800.0 2860800.0 True False 1689509.104609972 1442403.8155509864 2111470.657839638 1.0 0.8537413687888763 1.2497539386312317 20.688172694398403 -6.8067496881477165 1.4284340823417634 0.9199788311273895 1.2561601444255748 0.8510907163335565 0.06309319843202543 0.21127330366909503 0.8502657638066717 0.03473890171546721 0.08047259466877058 1.5604516323636327e-07 6.8067496881477165 0.33618131329818524 LELEENQMK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LELEENQMKR 10 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 12245200.0 2140000.0 4253100.0 5852100.0 True False 3246536.4549563085 3494101.075378025 4695429.869933455 1.0 1.0762549947787505 1.4462889713636824 21.630469978624394 -6.94047536857833 0.6551296775764375 0.9958780581815364 1.5474852672514285 0.998225462801805 0.008210687358436775 0.08755048516607994 0.05362779645244042 0.008021558345312868 0.0317819740135769 1.1468975669564919e-07 6.94047536857833 0.5516072090698921 LELEENQMK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LELEENQMKR 10 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 3346500.0 1038300.0 1145500.0 1162700.0 True False 1422187.5690024577 1094888.022338059 888094.2065581596 1.0 0.7698618988113002 0.6244564542081332 20.43968032051509 -9.705809038781558 0.07408382432066116 1.8017546414999381 1.0187339485248072e-11 0.999980776099222 0.0006778655619415367 1.2252133028671675 0.031613287734491 0.476713318975965 0.2932734441725037 1.9687517683386752e-10 9.705809038781558 -1.8017546414897507 LELEENQMK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LELEENQMKR 10 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 6222300.0 1744900.0 2114600.0 2362800.0 True False 1450961.6621766572 2103208.230084764 2856850.5556471506 1.0 1.4495270860083513 1.9689359340903962 20.46857796983268 -6.969231117476766 0.2759310395338259 0.8798184747550543 2.5543847017660752 0.9999757495634576 0.0019496358067577428 0.076552974833075 0.009919689987232035 0.009824657550408733 0.04792507978344952 1.073418021963549e-07 6.969231117476766 1.674566227011021 LELEENQMK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LELEENQMKR 10 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 10126500.0 2140000.0 3016300.0 4970200.0 True False 2770272.185706502 2848440.253459203 4065674.5985585824 1.0 1.028216746410702 1.4676083525423385 21.401596300716843 -6.9199728128650895 0.8249112757903638 0.9902961451389735 1.5384240862498477 0.9941738706831287 0.016341451128211063 0.09818736349866593 0.10569099414694351 0.014077906786733074 0.04216016569250009 1.2023396995582595e-07 6.9199728128650895 0.5481279411108743 LELEQTYQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LELEQTYQAK 10 0 Q03252 Q03252 LMNB2 Lamin-B2 0 16214500.0 2813100.0 5716100.0 7685300.0 False True 3688001.3420991553 4863280.161183289 6890098.878603158 1.0 1.3186763534134678 1.8682473891621243 21.81440775010212 -6.962835849955076 0.39343106236314557 0.9675112234588392 2.2392681724070544 0.9998613507255897 0.00422265617869178 0.07870321857718442 0.017498872006198464 0.007083758356708307 0.046163050362761936 1.0893417534306085e-07 6.962835849955076 1.2717569489482152 LELEQTYQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LELEQTYQAK 10 0 Q03252 Q03252 LMNB2 Lamin-B2 0 8070300.0 2454100.0 1112000.0 4504200.0 False True 2376195.938806424 1556027.399003392 3324414.896896425 1.0 0.6548396845526944 1.3990491451501668 21.180222373598067 -6.780599821992897 1.5336373985896958 0.8047148423514358 1.405045128472914 0.7694789141361094 0.14600041256781576 0.2496402953839211 1.1598186856236763 0.0749793780797294 0.17682365937255537 1.6572963657639038e-07 6.780599821992897 0.6003302861214782 LELEQTYQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LELEQTYQAK 10 0 Q03252 Q03252 LMNB2 Lamin-B2 0 5707500.0 2454100.0 1809000.0 1444400.0 False True 2040692.8850637465 1799254.5579416153 1746417.3618489662 1.0 0.8816880634566484 0.8557962712720548 20.960627649032343 -13.999999999999998 0.21352051234564173 1.694335876457429 0.8410565119344426 0.9994922706347669 0.0014144183140367363 12.83149442921695 0.14643601584370983 3.7441146509095176 0.014967411420934154 1.0000000000000041e-14 13.999999999999998 -0.8532793645229864 LELEQTYQAK(ub)LDSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LELEQTYQAKLDSAK 15 1 Q03252 Q03252 LMNB2 Lamin-B2 1 34011500.0 12462000.0 12728000.0 8821500.0 True False 16337802.68217966 10829032.013355408 7908735.801803159 1.0 0.6628205900152715 0.48407585497586864 23.961710628558762 -12.872397876913373 0.0885861762605766 2.464586624247832 4.741192476000816e-21 0.9998794700450947 0.002348428023975387 8.163369640737066 0.0747916834440018 2.5420052006348013 0.39358115360199225 1.3415353564632287e-13 12.872397876913373 -2.464586624247832 LELEQTYQAK(ub)LDSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LELEQTYQAKLDSAK 15 1 Q03252 Q03252 LMNB2 Lamin-B2 1 61549000.0 20437000.0 28018000.0 13094000.0 True False 19788238.621648196 39205733.51193976 9664288.588420087 1.0 1.9812644400320176 0.4883854886330016 24.238139866040886 -6.729389029438755 1.7253374574314249 1.5909140511878943 0.4893503136128558 0.5564974674885512 0.41252000336577344 0.337377818917615 1.967219344197451 0.18949079499908106 0.4705557467735099 1.8647085861559701e-07 6.729389029438755 -1.1015637375750384 LELEQTYQAK(ub)LDSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LELEQTYQAKLDSAK 15 1 Q03252 Q03252 LMNB2 Lamin-B2 1 35975800.0 12462000.0 14340000.0 9173800.0 True False 17069538.17288706 13706411.383961372 7007137.380341655 1.0 0.8029749396344175 0.41050538739657655 24.024920690081654 -6.960123424663704 0.43369167947816517 1.0149926281330333 0.18334505672036067 0.9997747469521374 0.0036775042602361905 0.07965707279609156 0.02096869730795994 0.005136882729656969 0.03256016306233095 1.0961666259307586e-07 6.960123424663704 -0.8316475714126725 down LELEQTYQAK(ub)LDSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LELEQTYQAKLDSAK 15 1 Q03252 Q03252 LMNB2 Lamin-B2 1 47148500.0 20437000.0 20284000.0 6427500.0 True False 16994271.01261063 20174726.065941233 7771460.5325977905 1.0 1.187148660332093 0.4572988465837084 24.018545141475162 -6.838685599978176 1.2885929448918891 1.0995794603662383 0.43392702584099757 0.9221526464841932 0.08635991651237084 0.17034039345752572 0.5500148106464566 0.05256427028074319 0.12105142998258919 1.4498210467411774e-07 6.838685599978176 -0.6656524345252408 down LELFLPEEYPMAAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LELFLPEEYPMAAPK 15 0 P61088;F8VSD4;F8VV71;F8VZ29 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 0 6364430.0 607030.0 2782800.0 2974600.0 False True 795822.2084868825 2367617.0872694426 2666816.926378016 1.0 2.9750578232430263 3.3510209917972813 19.602086634371737 -10.041007827015974 0.3931481133622181 3.189169002304056e-24 3.395409946849423 0.9989185267089997 0.0339102735773534 1.383173606069151 0.17698171192093476 1.6874443447532461 0.09729671349808235 9.098968739860782e-11 10.041007827015974 3.395409946849423 LELGK(ub)PDNNDGSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LELGKPDNNDGSK 13 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 11841300.0 2439200.0 5357800.0 4044300.0 True False 2028302.8748818266 5328936.46795997 4889944.431269582 1.0 2.6272883275730927 2.410855149803247 20.951841667160654 -10.370176386965873 8.44793117806941 0.9999927410844058 2.5190717386881696 0.9850034921444504 0.08835847482420092 1.2080108106136293e-05 9.007604720753903e-07 0.0855531328814936 0.028517575124201437 4.2640630041546765e-11 10.370176386965873 1.5190789976037637 LELGKPDNNDGSK(ub)LNSNSGAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LELGKPDNNDGSKLNSNSGAGR 22 2 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 26473800.0 8544700.0 7856100.0 10073000.0 True False 11202184.4469925 6684000.502837947 9030742.587038862 1.0 0.5966693848388142 0.8061590692218414 23.41727675216851 -10.077074587849893 4.87509764624875 1.0000094562203246 0.7014142270276856 0.7303595507612195 0.0855238055283066 118793663.35365005 0.5813723503135758 12609.976462776629 0.029277073430832967 8.373854531194297e-11 10.077074587849893 -0.2985952291926389 LELGKPDNNDGSK(ub)LNSNSGAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LELGKPDNNDGSKLNSNSGAGR 22 2 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 46929300.0 8997300.0 10509000.0 27423000.0 True False 8711685.636373019 14705298.503711035 20240093.627634373 1.0 1.6879969178770056 2.3233269050857346 23.05452046426186 -6.972080358988289 0.20242130788067006 0.6334520075973166 3.3954594789361408 0.9999943854423453 0.0012804407742241593 0.07563327203959064 0.0065554979437501965 0.02022187146555459 0.0670406122137697 1.0663987835720229e-07 6.972080358988289 2.762007471338824 LELGKPDNNDGSK(ub)LNSNSGAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LELGKPDNNDGSKLNSNSGAGR 22 2 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 49770000.0 12458000.0 16947000.0 20365000.0 True False 18899696.801797036 13922675.44248463 16339848.823703405 1.0 0.7366613120037366 0.864556135215342 24.171859754422304 -10.115965325829773 4.678051647752644 1.000014593053088 0.8006087236065379 0.7641924788663924 0.05221284294559765 72804203.83819678 0.3399534728324191 11444.15565230856 0.017873844918943553 7.656577347587055e-11 10.115965325829773 -0.19940586944655003 LELGKPDNNDGSK(ub)LNSNSGAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LELGKPDNNDGSKLNSNSGAGR 22 2 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 28730700.0 8544700.0 9414000.0 10772000.0 True False 11703906.501835022 8998058.352065029 8227875.456303846 1.0 0.768808119806344 0.7030024936557568 23.480486813691403 -13.999999999999998 0.17623553893424912 2.18615682533433 0.6486466604708047 0.9995031631670804 0.0028388516724722336 12.158282316960165 0.13303965785587527 4.934499125599255 0.05075084921230985 1.0000000000000041e-14 13.999999999999998 -1.5375101648635257 LELGKPDNNDGSK(ub)LNSNSGAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LELGKPDNNDGSKLNSNSGAGR 22 2 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 39800300.0 8997300.0 16531000.0 14272000.0 True False 7481653.597972387 16441944.221853426 17256209.21372782 1.0 2.197635055746149 2.3064699518304947 22.834925739696136 -10.744149201249565 0.45370600514263587 7.153071704959189e-12 2.3074767938024654 0.9995863955471836 0.01203748987369511 2.3202358066437276 0.21792522318980956 2.570577089970688 0.024298551891570055 1.8023984230763773e-11 10.744149201249565 2.3074767937953125 LELGKPDNNDGSK(ub)LNSNSGAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LELGKPDNNDGSKLNSNSGAGR 22 2 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 36922700.0 12458000.0 14569000.0 9895700.0 True False 16127126.58389326 13758222.34281973 8094784.138456428 1.0 0.8531105818044834 0.5019359212161811 23.942986076514753 -6.956412012807268 0.4833541663082419 1.0081687806030202 0.33215302319932033 0.9996131149215529 0.004110057366638783 0.08100860579081512 0.02606302494958528 0.004985642760566125 0.0289660948906167 1.105574433862036e-07 6.956412012807268 -0.6760157574036998 LELLLQIANK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LELLLQIANK 10 0 H3BQK9;Q9UPN3-4;Q9UPN3-2;Q9UPN3;A0A590UJG2;H3BPE1;Q9UPN3-3;E9PLY5;A0A5F9ZGX0;E9PLY0;E9PNZ4 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 0 14690000.0 3918300.0 6448300.0 4323400.0 False True 5944347.566100608 5297550.484202147 3468878.0949864625 1.0 0.89119124097201 0.5835590965051844 22.503087042069808 -6.952775685811409 0.5274919275856949 1.0049408545067773 0.45590398392134607 0.9994014910841126 0.004314346750415146 0.08238995210135962 0.0314950215952619 0.004831301675895395 0.025431534278392034 1.1148702181701048e-07 6.952775685811409 -0.5490368705854312 LELLLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LELLLQK 7 0 Q68DW7;Q8WVM7-2;Q8WVM7;Q8N3U4-2;Q8N3U4;B1AMT4 Q68DW7;Q8N3U4-2 DKFZp781D1416;STAG1;STAG2 Cohesin subunit SA-1;Cohesin subunit SA-2 0 3988900.0 1532000.0 1070800.0 1386100.0 False True 2008466.8359091063 911040.8139457093 1242679.668410061 1.0 0.45360012804659455 0.618720531597714 20.937663208917918 -10.898480171832716 11.304619479788174 1.0330160308835146 0.5361603298221542 0.913204900700872 0.0674101224704477 0.03456755367527613 0.00031042934247733163 0.04022271203730719 0.021756523474487185 1.2633387815396647e-11 10.898480171832716 -0.49685570106136034 LELLLQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LELLLQKR 8 1 Q68DW7;Q8WVM7-2;Q8WVM7;Q8N3U4-2;Q8N3U4;B1AMT4 Q68DW7;Q8N3U4-2 DKFZp781D1416;STAG1;STAG2 Cohesin subunit SA-1;Cohesin subunit SA-2 1 12639600.0 4370100.0 3654400.0 4615100.0 True False 5729243.420108594 3109177.764739634 4137573.723165198 1.0 0.5426855758697545 0.7221850111383072 22.44991320461969 -10.146850239650584 5.213055460659596 1.0000131164644612 0.6324352935037545 0.8482751916655765 0.07328033758858073 1.1171566140274096e-05 1.8284096028559417e-06 0.0709559117025735 0.023651127256946895 7.130988898652108e-11 10.146850239650584 -0.36757782296070673 LELLLQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LELLLQKR 8 1 Q68DW7;Q8WVM7-2;Q8WVM7;Q8N3U4-2;Q8N3U4;B1AMT4 Q68DW7;Q8N3U4-2 DKFZp781D1416;STAG1;STAG2 Cohesin subunit SA-1;Cohesin subunit SA-2 1 20663400.0 4264400.0 4778000.0 11621000.0 True False 4129028.956214545 6685880.316940841 8577111.477472875 1.0 1.6192379341099108 2.077270847074972 21.977371105261525 -6.97443106987071 0.10892417150551342 0.020861813468871615 3.687328602306628 0.999999634277182 0.0002668938347088817 0.07488914901767739 0.003216948507982132 0.036859520366872296 0.07061099349609955 1.0606422674901255e-07 6.97443106987071 3.6664667888377567 LELLLQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LELLLQKR 8 1 Q68DW7;Q8WVM7-2;Q8WVM7;Q8N3U4-2;Q8N3U4;B1AMT4 Q68DW7;Q8N3U4-2 DKFZp781D1416;STAG1;STAG2 Cohesin subunit SA-1;Cohesin subunit SA-2 1 41747500.0 8020500.0 0.0 33727000.0 True False 12167684.87709208 0.0 27060843.66693077 1.0 0.0 2.2239928088438434 23.536551359455657 -6.7844558860383986 1.5182958365887853 0.4370428285059188 2.2442000219717233 0.7828893850908807 0.4237710432068915 0.2437226050296885 1.1099088316215238 0.2197627830341074 0.5166975760492775 1.642646504909146e-07 6.7844558860383986 1.8071571934658044 LELLLQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LELLLQKR 8 1 Q68DW7;Q8WVM7-2;Q8WVM7;Q8N3U4-2;Q8N3U4;B1AMT4 Q68DW7;Q8N3U4-2 DKFZp781D1416;STAG1;STAG2 Cohesin subunit SA-1;Cohesin subunit SA-2 1 14522900.0 4370100.0 2790700.0 7362100.0 True False 5985844.067511933 2667397.646389195 5623323.607208934 1.0 0.44561762991228765 0.9394370357439525 22.513123266142582 -10.387424753788888 8.622338101722653 1.000001606851082 0.6925273328281212 0.34076538081875174 0.20160092822865777 6.2273090003628114e-06 4.424315234379381e-07 0.1952002787045176 0.0650664198007957 4.0980310647860847e-11 10.387424753788888 -0.3074742740229608 LELLLQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LELLLQKR 8 1 Q68DW7;Q8WVM7-2;Q8WVM7;Q8N3U4-2;Q8N3U4;B1AMT4 Q68DW7;Q8N3U4-2 DKFZp781D1416;STAG1;STAG2 Cohesin subunit SA-1;Cohesin subunit SA-2 1 19010900.0 4264400.0 5620500.0 9126000.0 True False 3546037.544951649 5590221.250918098 11034204.406143509 1.0 1.5764698427620065 3.111699824456868 21.757776380695802 -6.954093089813717 0.5119412080703486 0.9721903521671289 3.7835553979044265 0.99948457674502 0.020233403575325975 0.08188263069315584 0.029473728249775327 0.023227586947041592 0.12672332882439002 1.1114934562166644e-07 6.954093089813717 2.811365045737298 LELLLQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LELLLQKR 8 1 Q68DW7;Q8WVM7-2;Q8WVM7;Q8N3U4-2;Q8N3U4;B1AMT4 Q68DW7;Q8N3U4-2 DKFZp781D1416;STAG1;STAG2 Cohesin subunit SA-1;Cohesin subunit SA-2 1 49296500.0 8020500.0 27446000.0 13830000.0 True False 10382695.357691111 25918605.973027013 11313081.907783447 1.0 2.4963273100204644 1.0896093469026942 23.307677681548107 -6.6315845265211735 2.0743829411583365 1.984642517218479 1.095265753414573 0.1233401536448977 0.6415831035582118 0.5548881750466087 4.552162730838507 0.2527642097557495 0.7108069815469745 2.335691463497827e-07 6.6315845265211735 -0.8893767638039058 LELMEK(ub)DLCVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LELMEKDLCVK 11 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 45655600.0 19308900.0 21982700.0 4364000.0 True False 25314154.887653574 18702966.847893454 3912455.142443917 1.0 0.7388343371879824 0.15455602447751995 24.593440984930005 -7.198969034534015 0.5570471483061339 1.0049599033149705 7.560947786617519e-25 0.998544947967858 0.013482532175919552 0.08734015285993801 0.04672385022905367 0.013809562478754053 0.05094185016937597 6.324569443411144e-08 7.198969034534015 -1.0049599033149705 down LELMEK(ub)DLCVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LELMEKDLCVK 11 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 21800200.0 12205800.0 6668100.0 2926300.0 True False 11818333.560117135 9330707.103682121 2159814.242881756 1.0 0.7895112332224309 0.18275116638866887 23.49452328737113 -7.056928697957303 0.5763018142898416 1.005149132985754 3.9855359419156994e-11 0.9991412376950616 0.010153112534262624 0.07474777507613105 0.03769906367238244 0.01083784469959524 0.044608337800808695 8.771448180998447e-08 7.056928697957303 -1.0051491329458986 down LELMEK(ub)DLCVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LELMEKDLCVK 11 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 67462400.0 38106700.0 20623700.0 8732000.0 True False 57810649.872936286 16943239.60129644 7006116.372628435 1.0 0.2930816318193357 0.1211907561673737 25.784831954576923 -13.999999999999746 0.19861447951535474 4.909138890726755 0.008020577388786157 0.9994869244794975 0.00861401623260686 12.503837337234966 0.14131734554073944 18.97753715452663 0.11059265717662731 1.0000000000005849e-14 13.999999999999746 -4.901118313337969 LELMEK(ub)DLCVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LELMEKDLCVK 11 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 19905500.0 12205800.0 5259900.0 2439800.0 True False 10149663.508622749 5231563.874691597 2949950.8996393755 1.0 0.5154421001491398 0.290645192043383 23.274928562805407 -10.78868562733863 0.15418060031642153 1.9270505459859943 6.036109135898959e-13 0.9996465986472619 0.005564387790382376 2.7943603937154218 0.08549575872559576 1.1410515170088116 0.19832930664362097 1.6267258673956273e-11 10.78868562733863 -1.9270505459853908 LELMEK(ub)DLCVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LELMEKDLCVK 11 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 76039000.0 38106700.0 20309300.0 17623000.0 True False 49329874.345356084 19179069.601690497 14415794.827250011 1.0 0.38879218437530877 0.29223254708345137 25.555958276669372 -13.999999999999998 0.25973214703849945 5.468090080774838 0.25684998291929717 0.9995617878332951 0.006560033062749035 14.405268911904487 0.16127377088128883 33.777095734969286 0.04227415895969391 1.0000000000000041e-14 13.999999999999998 -5.211240097855541 LELPLWLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LELPLWLAK 9 0 Q9BRX5;Q9BRX5-3 Q9BRX5 GINS3 DNA replication complex GINS protein PSF3 0 2038460.0 340450.0 1088600.0 609410.0 False True 446333.24692249 926185.1233295654 546354.0990734982 1.0 2.075097765438043 1.2240945590333263 18.76776174995716 -10.202744467726834 4.495660486926544 0.9998307819310622 1.64959616181835 0.43722106493458635 0.34742060422717264 244294881.86463988 132.6222396939613 427934.10583876335 0.11893131366835702 6.269826632347342e-11 10.202744467726834 0.6497653798872877 LELPLWLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LELPLWLAK 9 0 Q9BRX5;Q9BRX5-3 Q9BRX5 GINS3 DNA replication complex GINS protein PSF3 0 3229370.0 340450.0 887420.0 2001500.0 False True 466323.565315311 848210.8500944916 1528786.9221864229 1.0 1.818931988824031 3.2783822991075153 18.83097181148005 -6.962236096258482 0.4026823142421649 0.9221075794470424 4.2287285149936915 0.9998443520006709 0.011756261960580073 0.07891181436089137 0.018249458705184057 0.01877516227553495 0.12215799283449248 1.0908471561060347e-07 6.962236096258482 3.306620935546649 LELQGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LELQGPR 7 0 P19338;H7BY16 P19338 NCL Nucleolin 0 16719500.0 4907000.0 1607500.0 10205000.0 False True 4751229.970956006 2249383.133001756 7532004.356562328 1.0 0.4734317527781448 1.5852746346956545 22.17986960767222 -6.777905758304868 1.5438776150020344 0.701031879663314 1.5935341460048114 0.7599556687868269 0.22249242329936383 0.25384440598716074 1.1949227866864116 0.11351962268372652 0.2683484045162872 1.6676090436569924e-07 6.777905758304868 0.8925022663414973 LELSLTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LELSLTLK 8 0 Q96BY7 Q96BY7 ATG2B Autophagy-related protein 2 homolog B 0 11030300.0 4028100.0 4441300.0 2560900.0 False True 6110922.193555843 3648715.3149647126 2054736.992517658 1.0 0.5970809641157592 0.3362400841372914 22.542958681557486 -8.412937311639261 0.1898304004630105 1.322240485439826 4.774023011770629e-06 0.9997801335119919 0.004048608619881353 0.12276931825665506 0.04532191778073301 0.13915660538702854 0.12641443679003217 3.864227513307439e-09 8.412937311639261 -1.3222357114168142 down LELSVHLQPITR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LELSVHLQPITR 12 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 6835600.0 3819000.0 3016600.0 0.0 False True 5006745.983248612 2566535.0386147043 0.0 1.0 0.5126153887578326 0.0 22.255441831615475 -7.89020106997594 0.600797384306831 1.0086526448922812 3.55253248667512e-18 0.9887025919362267 0.043397014387325204 0.11351627237963112 0.15985299434569436 0.0443106470698487 0.07734274748046294 1.2876532550238226e-08 7.89020106997594 -1.0086526448922812 down LELSVHLQPITR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LELSVHLQPITR 12 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 27798200.0 11121000.0 8065200.0 8612000.0 False True 10767969.94232764 11285676.419462379 6356258.845537951 1.0 1.0480783731666723 0.5902931452800807 23.360242952144304 -6.8809576468730285 1.0744972048488595 1.0301885887374371 0.557255434967467 0.9744474521091783 0.032835088336327346 0.12678273774252766 0.26721775443544776 0.023520205467610633 0.05701623109344384 1.3153531013802932e-07 6.8809576468730285 -0.47293315376997014 LELSVHLQPITR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LELSVHLQPITR 12 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 354613700.0 92097000.0 116890000.0 145626700.0 False True 139717882.19257525 96030066.2342616 116843518.9145499 1.0 0.687314069804622 0.8362817778292884 27.057941439112756 -10.118944347978035 4.758962669774412 1.0000138063781276 0.7617979238169322 0.7731986879087771 0.060815812149330455 9.858038518839605e-06 1.8251188927437458e-06 0.058888431505713185 0.019628218968006456 7.604237140655815e-11 10.118944347978035 -0.2382158825611954 LELSVHLQPITR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LELSVHLQPITR 12 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 18761200.0 3819000.0 7005500.0 7936700.0 False True 5230987.504594428 6695973.845909446 6062214.921467394 1.0 1.2800592316514434 1.158904492917043 22.318651893138366 -10.153462845226763 4.282979168866246 0.9999508200593082 1.2194818622950465 0.8139803824896492 0.04946121504961191 2.454746926486567e-05 4.851908462296785e-06 0.04790194121613168 0.015963538502813266 7.023234263583599e-11 10.153462845226763 0.21953104223573827 LELSVHLQPITR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LELSVHLQPITR 12 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 26911900.0 11121000.0 5885000.0 9905900.0 False True 9247604.243834374 5853296.336918959 11977177.890293336 1.0 0.6329527283589702 1.2951654909193202 23.14064822757858 -6.756193949442958 1.626366574718186 0.785806204799991 1.2971805210824203 0.675482970056781 0.15430921173797202 0.28931972542868933 1.507278259439112 0.07488769722277797 0.18068060738500405 1.7530974198186075e-07 6.756193949442958 0.5113743162824294 LELSVHLQPITR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LELSVHLQPITR 12 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 297187000.0 92097000.0 109040000.0 96050000.0 False True 119221382.00327645 102971828.14613657 78569885.55622554 1.0 0.8637026883592633 0.6590251197898903 26.829067761205206 -6.965238426675764 0.35393697231825827 1.0189048294922227 0.496874458306151 0.999917974103225 0.0012691398214836926 0.07788014775893641 0.01457521321043757 0.002782645099930348 0.01754762596688707 1.0833320039453395e-07 6.965238426675764 -0.5220303711860717 LELSVLYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LELSVLYK 8 0 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 24485600.0 9194100.0 7007500.0 8284000.0 False True 8902238.328095898 9805631.293629743 6114171.885327025 1.0 1.10147930579242 0.686812873345617 23.085736694037013 -6.84200678678418 1.2730965352713162 1.0539772647583094 0.6726279210367304 0.9278417748894642 0.04740873528388761 0.1664679051383632 0.5232412975440176 0.029190523177444003 0.06728779842721293 1.4387760941130858e-07 6.84200678678418 -0.381349343721579 LELSVLYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LELSVLYK 8 0 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 121615000.0 30456000.0 52454000.0 38705000.0 False True 46203978.63184545 43093173.87502745 31054939.784995843 1.0 0.9326723617979962 0.6721269618887681 25.461513751898146 -6.9456358135210365 0.6048682552328303 1.002906094064045 0.5884439754446567 0.998812709673821 0.004871848613873638 0.08528709086447003 0.04359099260318044 0.004976481397247255 0.021930968430905577 1.1333503588764464e-07 6.9456358135210365 -0.4144621186193884 LELSVLYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LELSVLYK 8 0 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 23135100.0 9194100.0 5363200.0 8577800.0 False True 7645301.517690637 5334307.377088153 10371378.320733927 1.0 0.6977236103435526 1.3565689066330946 22.86614196947129 -6.78194892279264 1.528112119764196 0.8292738438260329 1.3621245537153017 0.7742547712466461 0.1279405119807585 0.24757203403171837 1.1419677560134152 0.06593237103647676 0.1553319842560356 1.6521560962476113e-07 6.78194892279264 0.5328507098892689 LELSVLYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LELSVLYK 8 0 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 94179000.0 30456000.0 36807000.0 26916000.0 False True 39425892.3775127 34758658.09404663 22017564.18148222 1.0 0.8816200724443687 0.5584544281371892 25.232640073990595 -6.9535504162189605 0.518405019268803 1.0055598984312906 0.420132109482726 0.9994512471141866 0.004371442964349593 0.08209066334490966 0.030299032821720154 0.004964953978309474 0.02668956264012259 1.1128831933256253e-07 6.9535504162189605 -0.5854277889485646 LELSVLYK(ub)EYAEDDNIYQQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LELSVLYKEYAEDDNIYQQK 20 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 61115000.0 23554000.0 24621000.0 12940000.0 True False 35733140.02805648 20227190.18524896 10382403.328196518 1.0 0.5660624890330723 0.290553903744384 25.090759359658914 -8.461849816933329 0.21209286172731107 1.2888672014327243 9.694188164930858e-21 0.9996518542034105 0.005448840229110521 0.1429895450793268 0.053014359934769134 0.13989748321103096 0.12079935871819888 3.45263113886714e-09 8.461849816933329 -1.2888672014327243 down LELSVLYK(ub)EYAEDDNIYQQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LELSVLYKEYAEDDNIYQQK 20 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 65865000.0 23554000.0 25444000.0 16867000.0 True False 30491117.318752773 24028019.032926444 13797379.070034942 1.0 0.7880334059830806 0.4525048697231315 24.861885681751364 -6.9643474574457525 0.36908004414110424 1.0260729942355737 0.20280289420070952 0.9998990553501346 0.00226464777989022 0.0781830992066572 0.01564497583958509 0.004428799567639612 0.028510380307514224 1.0855567760401372e-07 6.9643474574457525 -0.8232701000348642 down LELVK(ub)GQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LELVKGQK 8 1 P50750;P50750-2 P50750 CDK9 Cyclin-dependent kinase 9 1 14283600.0 1322000.0 2595600.0 10366000.0 True False 2005570.6511459043 2132394.9004846346 8317155.556420797 1.0 1.0632359918441505 4.147026957972635 20.935581358843574 -6.911333576301596 0.8866198368474104 0.9084998691157706 4.557114373320986 0.991414812409659 0.1360977014653064 0.10354237544207028 0.13403842298440105 0.11216500294390641 0.3125566995375735 1.2264968120125292e-07 6.911333576301596 3.6486145042052156 up LELVK(ub)GQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LELVKGQK 8 1 P50750;P50750-2 P50750 CDK9 Cyclin-dependent kinase 9 1 28428200.0 1322000.0 1002200.0 26104000.0 True False 1711355.0605158838 946426.6889953976 21353339.849658605 1.0 0.5530276625997761 12.477445705055322 20.706707680936024 -6.898189016510561 0.9726256170415022 0.47929196626591314 13.68416837847417 0.9856441840408936 0.6612499526291018 0.11275132723790422 0.18502426385011936 0.5115765528097193 1.319372089934292 1.264186020338507e-07 6.898189016510561 13.204876412208257 up LEMIAMENPADLK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEMIAMENPADLKK 14 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 11848700.0 2046600.0 3296600.0 6505500.0 True False 2683112.4193025944 2804760.1300461525 5832373.265162444 1.0 1.045338283207372 2.173734213745102 21.355476072440158 -6.915364859104116 0.8584128861607603 0.9707065370808873 2.337612368406762 0.9927931983533448 0.04609113669901639 0.10097621088681842 0.12031907538610392 0.03876651490480613 0.11144000210843547 1.215164688588473e-07 6.915364859104116 1.3669058313258748 up LEMIAMENPADLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEMIAMENPADLKK 14 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 16103300.0 2464000.0 4060800.0 9578500.0 True False 2385781.6687254077 5682298.616792241 7069603.501159461 1.0 2.3817345448160734 2.9632231623844953 21.18603059229889 -9.539881320389792 0.24846275968640094 2.8936487920916255e-16 3.323101246911825 0.9991028598958234 0.024662067040333475 0.9450345409151419 0.10050658557044578 0.9915786220562695 0.2570556695833194 2.8848197298252415e-10 9.539881320389792 3.3231012469118246 LEMIAMENPADLK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEMIAMENPADLKK 14 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 15403300.0 2046600.0 3427600.0 9929100.0 True False 2803283.3272854034 3276157.2984425407 7584051.076233447 1.0 1.168685757359764 2.705417252125408 21.41868613396305 -6.927761956180061 0.7649361575891662 0.9745889737837093 3.0036459869531575 0.9960799079812762 0.04803979581066312 0.09381650925958201 0.08349504335377111 0.0431975940845214 0.1407974254714867 1.1809677657908484e-07 6.927761956180061 2.029057013169448 up LEMIAMENPADLK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEMIAMENPADLKK 14 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 52762400.0 9957400.0 23480000.0 19325000.0 True False 12890050.589698095 22173317.359421175 15808048.291244743 1.0 1.7201885442670328 1.2263759696861665 23.619754590080483 -10.240438545788793 4.155390175419957 0.999693920772249 1.473282256961263 0.5505155330075985 0.20159813995933404 142280985.30078626 259.666338572855 449571.25901443657 0.06901240541330905 5.748591577024423e-11 10.240438545788793 0.47358833618901397 LENLK(ub)SLDLFNCEVTNLNDYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LENLKSLDLFNCEVTNLNDYR 21 1 H0YN26;P39687 H0YN26 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 1 31508200.0 7321200.0 11474000.0 12713000.0 True False 11106795.651414061 9426375.05322881 10200269.977694146 1.0 0.8487033838628959 0.9183809892455795 23.404939318507306 -10.148091421299139 4.602776239521546 1.0000139644504242 0.883542186552433 0.7883456774548353 0.028445763287261634 4.076741273269126e-06 7.545771423353441e-07 0.027545793815626985 0.009180830622607286 7.110638151813527e-11 10.148091421299139 -0.11647177789799124 LENLK(ub)SLDLFNCEVTNLNDYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LENLKSLDLFNCEVTNLNDYR 21 1 H0YN26;P39687 H0YN26 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 1 8637200.0 3918300.0 1331100.0 3387800.0 True False 3258240.0601219507 1323929.1000973373 4096173.3165826197 1.0 0.40633258313317305 1.2571735786801745 21.635661471772192 -6.719112022164948 1.7626464989414423 0.6384765142848109 1.25576955876342 0.5082738928430672 0.24984480137875464 0.35703979049484746 2.1674725719257717 0.11257135982422743 0.28287725708807265 1.9093606934626487e-07 6.719112022164948 0.617293044478609 LENLK(ub)SLDLFNCEVTNLNDYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LENLKSLDLFNCEVTNLNDYR 21 1 H0YN26;P39687 H0YN26 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 1 26576200.0 7321200.0 13199000.0 6056000.0 True False 9477437.722427294 12464464.047146523 4953870.139807412 1.0 1.315172350608094 0.5227014183469266 23.176065640599756 -6.798803496870071 1.4609831664725121 1.1741568671665068 0.5121035427537961 0.82860040814557 0.13487180909321672 0.2224629262680985 0.9376024113544855 0.07263208416391545 0.1690257712605576 1.5892656733166056e-07 6.798803496870071 -0.6620533244127107 LENNENKPVTNSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LENNENKPVTNSR 13 1 Q9Y5A9;Q9Y5A9-2 Q9Y5A9 YTHDF2 YTH domain-containing family protein 2 0 5472620.0 1899300.0 826220.0 2747100.0 False True 1839007.7611242558 1156133.9546803797 2027552.0987665227 1.0 0.6286726892188812 1.1025250363962589 20.810496137661218 -6.697669366234072 1.838995435163405 0.7688970181757946 1.1010635764493697 0.4065836304449588 0.15680972135217228 0.4004036948964259 2.630914786407377 0.06806559176042874 0.17556418021311057 2.0059986377762626e-07 6.697669366234072 0.3321665582735751 LEQAMK(ub)EIQR ddPTM_RPMI8226_Bortezomib_1h_R1 2 LEQAMKEIQR 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 9941140.0 2550000.0 3893440.0 3497700.0 True False 3343074.694235123 3312553.9285102547 3135791.5563075324 1.0 0.9908704505533487 0.9379962588676123 21.672744158739178 -6.936589671046542 0.6905789164021329 1.000642815607469 0.9250637500302249 0.9976819362743966 0.0013159358862845016 0.0893577386450159 0.06196032609302824 0.0012499948151690255 0.004623282257988542 1.1572050732572015e-07 6.936589671046542 -0.07557906557724403 LEQAMK(ub)EIQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEQAMKEIQR 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 14836350.0 3835940.0 3604110.0 7396300.0 True False 3714170.184387396 5043249.918185352 5458987.145756189 1.0 1.3578402894365946 1.469773024591919 21.824608490829778 -12.352354129375035 0.18650984133261084 4.0026206149641946e-12 1.5601709825208054 0.9994485910336247 0.004704662325228812 6.226621124611068 0.12339983778836033 2.4308483660425844 0.07869596307033781 4.4426885712167714e-13 12.352354129375035 1.5601709825168029 LEQAMK(ub)EIQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEQAMKEIQR 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 18886600.0 5573500.0 4734900.0 8578200.0 True False 8455406.97742942 3889920.101057444 6882715.010041382 1.0 0.46005119699632036 0.8140016238619704 23.01144276573219 -9.894198746966904 5.4723282773111395 1.0000003225281013 0.6370264104273382 0.5837115401123005 0.14449965668324063 5.686108389523278e-07 1.1467472145461893e-07 0.13991131605196888 0.046637063654648134 1.275854803457407e-10 9.894198746966904 -0.36297391210076313 LEQAMK(ub)EIQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEQAMKEIQR 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 8211500.0 2550000.0 2102800.0 3558700.0 True False 3492803.911158881 2009891.3429702937 2718208.353727121 1.0 0.5754377841106545 0.7782310209407787 21.73595422026207 -10.086180977031653 4.934100007353833 1.0000100126852585 0.6768344025237761 0.7719998340098915 0.0827899922602448 9.119039387579815e-06 1.6887987362602302e-06 0.08016354824282218 0.026720355103755603 8.200097627412121e-11 10.086180977031653 -0.32317561016148233 LEQAMK(ub)EIQR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LEQAMKEIQR 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 18840290.0 5206540.0 8351000.0 5282750.0 True False 4329468.698830444 8306011.505456289 6387348.600323759 1.0 1.918482863197524 1.4753192700178723 22.045758561344904 -10.113033656587746 4.4451409947991705 0.9999256532609975 1.696901066632514 0.7672934337373717 0.18092077945126017 127095859.30539574 118506384.61604683 120792.23307683403 0.0662102322500138 7.708437285519731e-11 10.113033656587746 0.6969754133715165 LEQAMK(ub)EIQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEQAMKEIQR 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 16642700.0 5573500.0 5736400.0 5332800.0 True False 7215005.62010989 5417164.2972991355 4362285.119148772 1.0 0.7508191375763098 0.6046128511653649 22.78256908782464 -12.54836207635017 0.0669909518171205 2.269499520424575 5.405277477253978e-10 0.9999547319019316 0.0010982266765938843 7.309031880868895 0.05591786841736494 1.7864583054268277 0.47992661197007735 2.8290324151716896e-13 12.54836207635017 -2.2694995198840475 LEQDQLWIGTK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEQDQLWIGTKER 13 1 O14562;H3BRL3 O14562 UBFD1 Ubiquitin domain-containing protein UBFD1 1 14735500.0 6326400.0 4726100.0 3683000.0 True False 6125571.89489628 6613256.376285906 2718311.812368353 1.0 1.0796145224898848 0.44376457561998467 22.546413112445837 -6.875517108816622 1.1045511038006892 1.0469379592747867 0.4024129691857973 0.969883398480675 0.04908632064793056 0.1316724036124753 0.29694516218114925 0.03436132670622231 0.08222311004326148 1.3319345703750422e-07 6.875517108816622 -0.6445249900889894 down LEQDQLWIGTK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEQDQLWIGTKER 13 1 O14562;H3BRL3 O14562 UBFD1 Ubiquitin domain-containing protein UBFD1 1 14115700.0 6326400.0 5786400.0 2002900.0 True False 5260681.907040171 5755227.514689525 2421697.129636734 1.0 1.0940078903055366 0.4603390154413002 22.326818387880113 -6.8691562202085 1.1384754908419863 1.0529114675133349 0.4238067520964218 0.9638376468353014 0.053095077518295175 0.13767043645257288 0.3340152843366569 0.03621060643154373 0.08561149270377949 1.3515862961982965e-07 6.8691562202085 -0.629104715416913 down LEQELFSGGNTGINFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEQELFSGGNTGINFEK 17 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;F6S8Q4;A0A2R8YDH3;O15523-3;C9J081;C9J8G5;A0A2R8YCU0;A0A2R8Y650;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 14632600.0 4138300.0 1862900.0 8631400.0 False True 4006931.9316908913 2606765.6848951625 6370577.403550416 1.0 0.650564004913138 1.5898891002278859 21.934066571319963 -6.805947240762044 1.4313103520482304 0.808629801179834 1.604873407183353 0.8490413217475352 0.1506126257217598 0.2123709482102215 0.8581834526280994 0.08275570757046159 0.1918229923433554 1.5633375494701765e-07 6.805947240762044 0.7962436060035191 LEQIAAEQK(ub)ANPDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEQIAAEQKANPDGK 15 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 8524700.0 3093200.0 3596900.0 1834600.0 True False 4055215.154591412 3060256.5406063865 1644773.1907258485 1.0 0.7546471454520707 0.4055945561516254 21.95134702981543 -6.966122076674558 0.33824175512665167 1.0386392252687893 0.11003332719609411 0.9999344412430691 0.0019747521436640843 0.0775822340226064 0.013528613702615185 0.004954305243057899 0.03025125667845749 1.0811300116597678e-07 6.966122076674558 -0.9286058980726951 down LEQIAAEQK(ub)ANPDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEQIAAEQKANPDGK 15 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 13196900.0 5468700.0 4167000.0 3561200.0 True False 5295099.11191504 5830904.8306179335 2628414.8862900264 1.0 1.1011889876616705 0.49638634343511406 22.33622625768345 -6.86389514098982 1.1659569388836577 1.0555763965677576 0.4648523961093531 0.958195247328795 0.05408065245484579 0.14284348303803962 0.3668195498987728 0.03611576799386183 0.08470655451401675 1.3680590992055964e-07 6.86389514098982 -0.5907240004584045 down LEQIAAEQK(ub)ANPDGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEQIAAEQKANPDGK 15 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 28304500.0 9398500.0 9349100.0 9556900.0 True False 14258211.622386388 7680680.060148299 7667974.526061933 1.0 0.5386846726337751 0.5377935697084673 23.765289703124132 LEQIAAEQK(ub)ANPDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEQIAAEQKANPDGK 15 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 9986000.0 3093200.0 3645100.0 3247700.0 True False 4236839.630586929 3484047.429266221 2480660.148481066 1.0 0.8223222337975479 0.5854977683300749 22.01455709133832 -6.967145768346865 0.31908776731028354 1.0327822081726077 0.3674094028783212 0.99995078777295 0.0011911089364786945 0.07724018247061074 0.012331131644411858 0.0036031575464376144 0.020848507192735465 1.0785846409804964e-07 6.967145768346865 -0.6653728052942864 LEQIAAEQK(ub)ANPDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEQIAAEQKANPDGK 15 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 12087400.0 5468700.0 4913700.0 1705000.0 True False 4547466.354487641 4887228.922806915 2061507.6169707046 1.0 1.0747146964559686 0.4533310323310733 22.116631533117726 -6.876857920299944 1.0971136694633012 1.0446409906343388 0.4118535748767058 0.9710640662986278 0.04711878505317386 0.13045259285183305 0.2893812600090026 0.03317061856580993 0.07961632443885308 1.3278287866637926e-07 6.876857920299944 -0.632787415757633 down LEQIAAEQK(ub)ANPDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEQIAAEQKANPDGK 15 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 31767300.0 9398500.0 9356800.0 13012000.0 True False 12166543.52213204 8836085.854711762 10643949.514394663 1.0 0.7262609827218491 0.874854020374181 23.53641602521658 -10.138220905511725 4.801234491345588 1.0000145282791997 0.8005575015467334 0.7060572780763346 0.06066285360080933 9.434591177886792e-06 1.6934061475986817e-06 0.05874083232029338 0.019578851810152325 7.274097107513912e-11 10.138220905511725 -0.19945702673246624 LEQK(ub)GAEADQIIEYLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEQKGAEADQIIEYLK 16 1 Q12904;Q12904-2;A0A5F9ZHC5;D6R937 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 1 9864600.0 2355200.0 3149900.0 4359500.0 True False 2280435.4651713036 4407671.4965115 3217616.167803379 1.0 1.9328200967881375 1.4109656760498044 21.120877912773643 -10.283476360955044 4.983327666190133 0.9998194373295656 1.6718928864193014 0.6884971334069491 0.21304617513857962 0.0004275014278032242 6.146825403127558e-05 0.20633560486111643 0.06876035735691177 5.20623346034139e-11 10.283476360955044 0.6720734490897359 LEQK(ub)GAEADQIIEYLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEQKGAEADQIIEYLK 16 1 Q12904;Q12904-2;A0A5F9ZHC5;D6R937 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 1 9141300.0 2355200.0 3348300.0 3437800.0 True False 1958453.1530508704 3330262.043314484 4156628.085408739 1.0 1.7004552996974245 2.122403632138742 20.90128318820792 -9.018016739915414 0.14131603086035438 2.503653409408391e-20 2.9093579946292256 0.9998685413043372 0.005307369922789301 0.49409944175080023 0.04657526726728442 0.5491004123050325 0.3436335824850661 9.5936365205483e-10 9.018016739915414 2.9093579946292256 LEQMPSK(ub)EDAIEHFMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEQMPSKEDAIEHFMK 16 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 6282800.0 1365100.0 2583500.0 2334200.0 True False 1789659.3196472046 2198051.8704041266 2092679.3752274464 1.0 1.2281956941600642 1.1693171724102083 20.77125355087325 -10.057089054700613 4.339044926838689 0.9999844483668068 1.198756433279072 0.9382480910139863 0.02403705594781583 16660781.068438407 0.0902371075688561 2680.971490466176 0.008228523584572357 8.76821005277164e-11 10.057089054700613 0.19877198491226533 LEQMPSK(ub)EDAIEHFMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEQMPSKEDAIEHFMK 16 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 11433200.0 2498600.0 4679700.0 4254900.0 True False 3790558.8721279586 3844570.9723370164 3413917.1500110766 1.0 1.0142491126061146 0.9006368889594791 21.853979141363364 -6.875459273963272 1.1048536567449416 1.0083964776908068 0.8932560503485506 0.9698325257830889 0.008777262136968042 0.13172609339183391 0.29726406850937814 0.006142781118950175 0.014697357764908079 1.3321119554747067e-07 6.875459273963272 -0.11514042734225616 LEQMPSK(ub)EDAIEHFMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEQMPSKEDAIEHFMK 16 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 6965600.0 2696000.0 2486000.0 1783600.0 True False 2241843.4530507564 2472607.424567637 2156542.5135653713 1.0 1.1029349177806556 0.9619505370148369 21.096254108220126 -6.710972096160898 1.7918012481893502 1.0632200802335563 0.9622733245443661 0.46965953130817895 0.04336978404984745 0.373140993696171 2.335884902197287 0.01925767272485784 0.04886483024578172 1.9454850768986348e-07 6.710972096160898 -0.1009467556891902 LEQQCQK(ub)QQEQADSLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEQQCQKQQEQADSLER 17 1 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 1 9732800.0 3197000.0 3494300.0 3041500.0 True False 4850082.7320071515 2870714.8639094853 2440346.1918631927 1.0 0.5918898753963053 0.5031555803695091 22.209577926116403 -13.999999999999998 0.21443875247404973 3.4043764826040013 0.45308600474752836 0.999492963297903 0.004871745630417997 12.85428394327848 0.1467426784738105 13.050174457687456 0.05097372530235622 1.0000000000000041e-14 13.999999999999998 -2.951290477856473 LEQQCQK(ub)QQEQADSLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEQQCQKQQEQADSLER 17 1 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 1 4041500.0 1370100.0 1415800.0 1255600.0 True False 1876662.9955603075 1353245.27457549 959053.1398937162 1.0 0.7210912549439689 0.5110417491912956 20.839738168727997 -7.345561943548681 0.14124625954868342 1.304587317665623 2.431313635419713e-10 0.9999941070152726 0.0004861429567451949 0.11492624397464099 0.009163770894032704 0.028347081743530015 0.0518596956088465 4.512716557425979e-08 7.345561943548681 -1.3045873174224918 LEQQCQK(ub)QQEQADSLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEQQCQKQQEQADSLER 17 1 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 1 9245700.0 3197000.0 3318900.0 2729800.0 True False 4138579.5222914363 3134200.29745243 2233004.410113322 1.0 0.7573130540493022 0.5395581740270533 21.980704248208852 -6.972410473380791 0.19207882126281567 1.1436326777755648 0.14727692383758467 0.9999955861570845 0.00039506934448955196 0.07552803194941492 0.00614278959249534 0.00755305844201593 0.02360261523841467 1.0655885042756131e-07 6.972410473380791 -0.9963557539379801 LEQQK(ub)QTVQMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEQQKQTVQMR 11 1 O14964;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 11196400.0 1103000.0 2750400.0 7343000.0 True False 1067985.868751676 3848649.06314652 5419648.014721922 1.0 3.60365167344868 5.074643937992102 20.026461127195375 -8.586351377539426 0.2827798526211597 1.4956894835058806e-16 5.9449955491683175 0.9989281679653201 0.05515687885716294 0.2112244468834979 0.08155338655591517 0.6981506514735221 0.509247890256088 2.5920813209345955e-09 8.586351377539426 5.9449955491683175 LEQQK(ub)QTVQMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEQQKQTVQMR 11 1 O14964;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 9087300.0 1103000.0 3994200.0 3990100.0 True False 917193.371185084 3972682.451813375 4824411.461862061 1.0 4.331346667584793 5.259972011821839 19.80686640262965 -9.411237309668241 0.3985187305002956 1.7561945575533075e-22 5.3937984824728735 0.9981795293768896 0.07803842323565274 0.7674897350543315 0.16136156736925017 1.371082534850384 0.23497965801388795 3.879383285900728e-10 9.411237309668241 5.3937984824728735 LEQQK(ub)QTVQMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEQQKQTVQMR 11 1 O14964;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 5675050.0 1958150.0 1004300.0 2712600.0 True False 2534863.7759070965 948409.822149348 2218934.633626417 1.0 0.3741462681993478 0.8753664219420924 21.273476787912173 -10.079161035546477 7.250066742243554 1.0000000790987107 0.6247563450707594 0.42769599610133135 0.2046222709115102 2.6171523502150195e-07 3.298388785074161e-08 0.19812470320753542 0.06604155395861845 8.333721145679168e-11 10.079161035546477 -0.3752437340279513 LEQQVPVNQVFGQDEMIDVIGVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEQQVPVNQVFGQDEMIDVIGVTK 24 0 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2 P39023 RPL3 60S ribosomal protein L3 0 11216300.0 3758600.0 1475900.0 5981800.0 False True 3639285.300353626 2065234.5667168214 4414987.1298466 1.0 0.5674835568720442 1.2131467487359675 21.795223724452985 -6.726237058541983 1.7374389556193788 0.7386216143185502 1.2124719490927787 0.5415326982512203 0.18187934239286413 0.3433306887830225 2.0287193110218653 0.08302604015777693 0.2068685832928038 1.87829127640278e-07 6.726237058541983 0.47385033477422844 LEQQVPVNQVFGQDEMIDVIGVTKGK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEQQVPVNQVFGQDEMIDVIGVTKGK 26 1 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2 P39023 RPL3 60S ribosomal protein L3 1 15786400.0 3452400.0 3103400.0 9230600.0 True False 3342805.4517482133 4342603.804017202 6812828.947935728 1.0 1.2990896020425347 2.0380572684458107 21.67262796317707 -6.955713823867409 0.49213930405100137 0.984137400300321 2.3844588030336835 0.9995767190655639 0.008976007093706051 0.08126933043023879 0.02707103158829911 0.010688963837941674 0.06094828429528141 1.1073532283783165e-07 6.955713823867409 1.4003214027333626 up LEQQVPVNQVFGQDEMIDVIGVTKGK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEQQVPVNQVFGQDEMIDVIGVTKGK 26 1 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2 P39023 RPL3 60S ribosomal protein L3 1 13632100.0 3452400.0 3327900.0 6851800.0 True False 2870823.5672523826 3309971.942163568 8284479.700856245 1.0 1.1529694753521502 2.8857502060933626 21.453033238611347 -6.92424257761208 0.7926242343479979 0.967291088983327 3.194395640988099 0.9952806451389018 0.05874872206300788 0.09573920536733187 0.09314614214556656 0.05179087474882013 0.16203210770468474 1.1905768189304537e-07 6.92424257761208 2.2271045520047723 up LEQTQK(ub)SK(ub)PVFSESLSD ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEQTQKSKPVFSESLSD 17 2 O60220 O60220 TIMM8A Mitochondrial import inner membrane translocase subunit Tim8 A 2 6194200.0 2098600.0 2469900.0 1625700.0 True False 2751284.922871306 2101400.5475947936 1457488.1588155534 1.0 0.7637887774275746 0.529748172099342 21.39167412211106 -6.971239656955888 0.2266450732455385 1.0992691661028686 0.18760741384113833 0.9999904997719097 0.0005917016121661913 0.07590257615036397 0.007575529871961284 0.006165104592338356 0.023398999558420217 1.0684651048404403e-07 6.971239656955888 -0.9116617522617303 LEQTQK(ub)SK(ub)PVFSESLSD ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEQTQKSKPVFSESLSD 17 2 O60220 O60220 TIMM8A Mitochondrial import inner membrane translocase subunit Tim8 A 2 12038300.0 4084900.0 5593600.0 2359800.0 True False 3955227.0854612133 7827153.650238656 1741697.587517468 1.0 1.9789391307037794 0.44035337286186976 21.91532909731269 -6.734759769769305 1.7055073887767687 1.5859506504906722 0.44037169962532613 0.5814011016528846 0.41139141638122206 0.3273571993988844 1.8674280835089403 0.19097507084643653 0.4714261536331583 1.8417905071779946e-07 6.734759769769305 -1.145578950865346 LEQTQK(ub)SK(ub)PVFSESLSD ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEQTQKSKPVFSESLSD 17 2 O60220 O60220 TIMM8A Mitochondrial import inner membrane translocase subunit Tim8 A 2 8803000.0 2098600.0 3188100.0 3516300.0 True False 2874509.1325325603 3047239.2003631336 2685822.360471705 1.0 1.060090283198506 0.9343586110319244 21.45488418363395 -6.776753020825843 1.548547803370514 1.0341687694731536 0.9334628643224295 0.7557011541275689 0.025378784131799954 0.2556649538290901 1.2107181284165598 0.012911243747398254 0.030548513623242908 1.6720412180498852e-07 6.776753020825843 -0.10070590515072408 LEQTQK(ub)SK(ub)PVFSESLSD ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEQTQKSKPVFSESLSD 17 2 O60220 O60220 TIMM8A Mitochondrial import inner membrane translocase subunit Tim8 A 2 11866100.0 4084900.0 5335500.0 2445700.0 True False 3396775.3417533515 5306756.602486173 2957084.562360854 1.0 1.5622924887775842 0.8705564144947139 21.695734372746966 -6.690556701293053 1.8649049337105605 1.3523445139702481 0.8729606146155129 0.37286947660582104 0.23778393915047252 0.4154462628444502 2.8018985357378985 0.10199671573285365 0.26537458514408646 2.039122415319328e-07 6.690556701293053 -0.47938389935473524 LEQTQK(ub)SK(ub)PVFSESLSD ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEQTQKSKPVFSESLSD 17 2 O60220 O60220 TIMM8A Mitochondrial import inner membrane translocase subunit Tim8 A 2 17523100.0 8913300.0 4566700.0 4043100.0 True False 11538442.557410175 4312559.130548068 3307297.2857092675 1.0 0.3737557394848296 0.2866329029462705 23.459945168408392 -13.999999999999998 0.27788740312840926 6.044922229482277 0.2598544741848799 0.9996005124554519 0.0063508529689836205 15.28515485902544 0.16696072714588858 43.76930076218755 0.03481278191260072 1.0000000000000041e-14 13.999999999999998 -5.785067755297398 LEQTQK(ub)SKPVFSESLSD ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEQTQKSKPVFSESLSD 17 2 O60220 O60220 TIMM8A Mitochondrial import inner membrane translocase subunit Tim8 A 1 78454900.0 1199000.0 52495800.0 24760100.0 True False 1571900.6111325163 44663631.26702569 22198162.367650192 1.0 28.41377562341338 14.121861274458666 20.584078570407183 -9.820936694350195 15.119761795414671 1.0000000000032832 21.267818448935824 0.7283689164756739 5.834649600416715 0.0 0.0 5.649375183342424 1.883125061114141 1.51030028952653e-10 9.820936694350195 20.26781844893254 LEQTQK(ub)SKPVFSESLSD ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEQTQKSKPVFSESLSD 17 2 O60220 O60220 TIMM8A Mitochondrial import inner membrane translocase subunit Tim8 A 1 343196100.0 185013000.0 83467500.0 74715600.0 True False 280678247.2620704 68572072.49044596 59948028.91098922 1.0 0.2443084676470134 0.21358273929584398 28.06434201752294 -13.279812962770823 0.4644637329736092 9.999966102775183 0.21409782723248036 0.9999024898440328 0.0035913818560569313 19.268334395652246 0.2338704188832573 174.5153563598346 0.006721033698335827 5.2503352730166416e-14 13.279812962770823 -9.785868275542702 LEQTQK(ub)SKPVFSESLSD ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEQTQKSKPVFSESLSD 17 2 O60220 O60220 TIMM8A Mitochondrial import inner membrane translocase subunit Tim8 A 1 51248900.0 1199000.0 33131900.0 16918000.0 True False 1642302.7017566676 31668023.105458137 12922316.837147096 1.0 19.282695614873465 7.868413553314446 20.647288631930074 -9.576387438324367 10.793582643904163 1.000077013298038 13.575554584093956 0.6180927948805931 4.65986113871594 0.0 0.0 4.511891146375639 1.5039637154585461 2.652238418609885e-10 9.576387438324367 12.575477570795918 LEQTQK(ub)SKPVFSESLSD ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEQTQKSKPVFSESLSD 17 2 O60220 O60220 TIMM8A Mitochondrial import inner membrane translocase subunit Tim8 A 1 90212900.0 3087600.0 72957300.0 14168000.0 True False 2567476.203872225 72564264.54400979 17130463.294569507 1.0 28.262877153279774 6.672102070014759 21.291919474605862 -9.641799861395663 11.37397908375655 0.9965379024882561 17.46748961602082 0.43682097666764275 8.814397244171754 0.0 0.0 8.534503330977028 2.8448344436590087 2.281393178275343e-10 9.641799861395663 16.470951713532564 LEQTQK(ub)SKPVFSESLSD ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEQTQKSKPVFSESLSD 17 2 O60220 O60220 TIMM8A Mitochondrial import inner membrane translocase subunit Tim8 A 1 274133100.0 185013000.0 85169500.0 3950600.0 True False 239502975.65145624 80429742.45499244 3231631.336579119 1.0 0.3358193869459067 0.013493073845070074 27.83546833961539 -8.636613736566892 0.4725238016303401 1.0752319217961879 4.813759228599236e-18 0.9951057197431875 0.028733688134011472 0.277202436726528 0.17131108726508168 0.10293216454617703 0.06656934470180045 2.3087997325080194e-09 8.636613736566892 -1.0752319217961879 LEQVK(ub)QSLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LEQVKQSLQR 10 1 Q9Y4B6;Q9Y4B6-2 Q9Y4B6 VPRBP Protein VPRBP 1 12264430.0 597630.0 1674100.0 9992700.0 True False 773643.8160484927 1580934.8633478272 8174131.133760486 1.0 2.0434918893589824 10.565755150104016 19.56130997996223 -6.929713369133277 0.7491436022068051 0.8690154368674666 12.302615690159028 0.9964815797020421 0.2541475385792185 0.09278690529946919 0.07841191690268723 0.23114715237503677 0.7723366664829107 1.175673233823437e-07 6.929713369133277 11.433600253291562 LESADK(ub)SDQNNTAEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LESADKSDQNNTAEGK 16 1 Q9NXG2 Q9NXG2 THUMPD1 THUMP domain-containing protein 1 1 2370280.0 944450.0 835580.0 590250.0 True False 914468.9517157936 1169231.4514921368 435645.8178795603 1.0 1.2785906501235926 0.47639213672828334 19.802574662490564 -6.812913850040226 1.4023265905955384 1.1513123442204272 0.46141157336289723 0.8672891122170948 0.12114600896622173 0.20284836966813072 0.7856479925531739 0.06791912787235993 0.1569081387164596 1.5384597906326398e-07 6.812913850040226 -0.68990077085753 down LESADK(ub)SDQNNTAEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LESADKSDQNNTAEGK 16 1 Q9NXG2 Q9NXG2 THUMPD1 THUMP domain-containing protein 1 1 3265110.0 1259100.0 980210.0 1025800.0 True False 1910146.7525399483 805283.8670843148 823050.180375888 1.0 0.4215821983381737 0.4308832184131753 20.865252051055588 -10.339605254729593 5.783756043568659 1.0000869308023301 0.42623270837567284 0.9998029546127745 0.0037971255451963674 4.257020815788807e-06 4.860703262538325e-07 0.0036771030458669007 0.001225516999999353 4.57503841745998e-11 10.339605254729593 -0.5738542224266573 LESLEAK(ub)NR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LESLEAKNR 9 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 2972830.0 667340.0 940490.0 1365000.0 True False 874889.2025297522 800172.5580013058 1223762.8940045692 1.0 0.9145987351170841 1.3987632839290332 19.738740797573676 -6.861338847428598 1.178837515759157 0.9534845136232035 1.422828365932685 0.9552542518927449 0.044635005712659596 0.14543534344565914 0.3832629780592076 0.02951360098840723 0.0690060179294661 1.3761353546637934e-07 6.861338847428598 0.4693438523094815 LESLEAK(ub)NR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LESLEAKNR 9 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 25926100.0 1640200.0 3708900.0 20577000.0 True False 2488303.314681934 3047017.8172320374 16509946.9307805 1.0 1.2245363333535246 6.635021877504059 21.24673092453387 -6.915624809299921 0.8565347372942935 0.8607831157698793 7.425407307060719 0.9928770164491677 0.21986162047747895 0.10081521800632672 0.11945538239707199 0.18516820323290503 0.5334574647323309 1.2144375603519883e-07 6.915624809299921 6.564624191290839 up LESLEAK(ub)NR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LESLEAKNR 9 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 32166300.0 1640200.0 3347100.0 27179000.0 True False 2123271.23317561 3160830.9426626363 22232700.880090065 1.0 1.4886609366129966 10.470965994692238 21.01785724662632 -6.918133088719417 0.8384464072317421 0.7881614651582852 11.85906550517307 0.9936465908275784 0.3470538449922715 0.09928304650349594 0.11139494038621639 0.29610270914473374 0.8717518402270462 1.2074437595575685e-07 6.918133088719417 11.070904040014785 up LESLLEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LESLLEKR 8 1 D6W5U7;Q9UJ98-2;Q9UJ98-3;Q9UJ98 D6W5U7 STAG3 Cohesin subunit SA-3 1 22111300.0 5986100.0 10663000.0 5462200.0 True False 5796074.53212548 14920791.506810408 4031485.9575124695 1.0 2.5742925533669427 0.6955545404337792 22.466644716054155 -6.684442140033143 1.8860962420397427 1.992094978948091 0.7024540158264465 0.34449486509445093 0.6665888947701737 0.42877716150264383 2.952727919890065 0.2831961792278071 0.7426895136471992 2.0680348826783645e-07 6.684442140033143 -1.2896409631216446 LESLLEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LESLLEKR 8 1 D6W5U7;Q9UJ98-2;Q9UJ98-3;Q9UJ98 D6W5U7 STAG3 Cohesin subunit SA-3 1 18919900.0 8397500.0 7148000.0 3374400.0 True False 11502282.683904607 6832177.724724964 2577436.217949472 1.0 0.5939845083346263 0.22408040984387684 23.455416863637712 -7.704492204996784 0.3250697895104482 1.0836771243809677 4.0506000620956074e-22 0.9992932585003887 0.008424187202070001 0.1228083125241541 0.04721656842465997 0.03284075059988876 0.07728215205856359 1.9747303228508607e-08 7.704492204996784 -1.0836771243809677 down LESLLEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LESLLEKR 8 1 D6W5U7;Q9UJ98-2;Q9UJ98-3;Q9UJ98 D6W5U7 STAG3 Cohesin subunit SA-3 1 15861900.0 5986100.0 6342500.0 3533300.0 True False 4977707.379194042 6308331.693612322 4272096.69386663 1.0 1.2673167008530997 0.858245848625666 22.24704999148843 -6.730390532128563 1.7219368235272487 1.1607998822330605 0.8584773173699124 0.5610404487449312 0.11236985629571015 0.3354952740938208 1.949042687704912 0.05171204197724485 0.12825682289226212 1.8604134382442687e-07 6.730390532128563 -0.3023225648631481 LESLSAATTFEPLEPVK(ub)DTDIQGFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LESLSAATTFEPLEPVKDTDIQGFLK 26 1 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 77700000.0 11044000.0 21921000.0 44735000.0 True False 16754555.424550202 18009026.28044525 35893107.64195299 1.0 1.074873419443699 2.1422894688903145 23.998050069923952 -6.921058370058541 0.8168404987175741 0.9773348427529976 2.31868030423405 0.9944698909401203 0.038798205397409975 0.09755293293404477 0.10241711883908047 0.03361736513775385 0.10174150373254895 1.199338098845378e-07 6.921058370058541 1.3413454614810525 up LESLSAATTFEPLEPVK(ub)DTDIQGFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LESLSAATTFEPLEPVKDTDIQGFLK 26 1 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 15206900.0 5426500.0 5843400.0 3937000.0 True False 4512375.184710654 5811920.44437591 4760208.497368728 1.0 1.2879958351132954 1.0549230288956934 22.105455595974536 -10.562686417839947 6.596396890700413 0.9997764022511051 1.1714594320044944 0.4191347571213926 0.09515157469195122 0.00031329470461476664 2.077004316265223e-05 0.09224920198680699 0.03071003867894483 2.7372444392115645e-11 10.562686417839947 0.17168302975338934 LESLSAATTFEPLEPVK(ub)DTDIQGFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LESLSAATTFEPLEPVKDTDIQGFLK 26 1 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 73840000.0 11044000.0 13361000.0 49435000.0 True False 14296675.70978625 12617448.604737077 40438337.24593453 1.0 0.8825442264246282 2.828513289858984 23.7691763920164 -6.89255286488955 1.007192341836913 0.9017492518406367 3.0044800840503147 0.9824814590801453 0.11792340845634453 0.1170950058367561 0.209960298531559 0.0889002194416043 0.22375932305536975 1.280699190777601e-07 6.89255286488955 2.1027308322096783 up LESLSAATTFEPLEPVKDTDIQGFLKNEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LESLSAATTFEPLEPVKDTDIQGFLKNEK 29 2 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 19909900.0 6048800.0 4610700.0 9250400.0 True False 5856784.154945725 6451776.55448286 6827442.733948466 1.0 1.1015902897897811 1.1657323461686864 22.481677295882335 LESLSAATTFEPLEPVKDTDIQGFLKNEK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 LESLSAATTFEPLEPVKDTDIQGFLKNEK 29 2 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 82763000.0 10065000.0 19379000.0 53319000.0 True False 15269340.8500632 15920666.041181924 42780476.2794521 1.0 1.0426557503375156 2.801723839917755 23.864134449144586 -6.91211695542158 0.8811995636078757 0.9491144888451096 3.039652703123388 0.9916961341360283 0.07649692356429343 0.10303458792392096 0.13129869689098267 0.06329213425309808 0.17738585311590377 1.224286454756986e-07 6.91211695542158 2.0905382142782787 up LESLSAATTFEPLEPVKDTDIQGFLKNEK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LESLSAATTFEPLEPVKDTDIQGFLKNEK 29 2 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 22232100.0 6048800.0 5538300.0 10645000.0 True False 5029845.207275007 5508464.0786335245 12870820.283081044 1.0 1.0951557854437068 2.558889936506416 22.26208257131661 -6.920121805012506 0.8238354315189066 0.9678454279518606 2.795583110362731 0.9942144533025002 0.05427061571485812 0.09809998505067707 0.10524727432029017 0.0467898791761002 0.1403188640385761 1.2019272871137995e-07 6.920121805012506 1.8277376824108704 up LESLSAATTFEPLEPVKDTDIQGFLKNEK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LESLSAATTFEPLEPVKDTDIQGFLKNEK 29 2 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 88994900.0 10065000.0 9966900.0 68963000.0 True False 13029340.910811188 9412233.25339075 56412441.620135196 1.0 0.7223875188944425 4.329646603484492 23.635260771237036 -6.888323611981594 1.032274070787006 0.798315985959246 4.629873690886784 0.9798024927143674 0.23292669056822363 0.12051279213043056 0.22988994510417757 0.1722991704653373 0.42702226456452447 1.293231838227749e-07 6.888323611981594 3.831557704927538 up LESLSYQLSGLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LESLSYQLSGLQK 13 0 Q03252 Q03252 LMNB2 Lamin-B2 0 41528900.0 6807900.0 10862000.0 23859000.0 False True 8925222.827797389 9241431.939744385 21390299.55168864 1.0 1.035428707837094 2.3966123831742414 23.089456757350536 -6.912485585444586 0.8786275656880064 0.9610952849036343 2.5822120740540786 0.9918264395459953 0.058781277190533505 0.10279754465292058 0.13001786159120204 0.04872439545271269 0.13693627308763712 1.2232477188736622e-07 6.912485585444586 1.6211167891504443 up LESLSYQLSGLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LESLSYQLSGLQK 13 0 Q03252 Q03252 LMNB2 Lamin-B2 0 18998700.0 6452700.0 2070000.0 10476000.0 False True 6247862.570529405 2896561.7949073953 7732021.326736584 1.0 0.4636084360386241 1.237546639263133 22.57493128928994 -6.720318141292112 1.7585673001731987 0.6737705733334439 1.2363294973579058 0.5138596200186054 0.22570653993289594 0.35468948527687 2.14395160523901 0.10191131629442039 0.2557015025049098 1.9040653888095885e-07 6.720318141292112 0.5625589240244618 LESLSYQLSGLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LESLSYQLSGLQK 13 0 Q03252 Q03252 LMNB2 Lamin-B2 0 22670200.0 6807900.0 4521300.0 11341000.0 False True 9324964.60657984 4321534.016060298 8662489.375226699 1.0 0.4634370422179358 0.9289568101003098 23.152666818873428 -10.249192410725472 8.072129729810571 1.0000002642262134 0.696196926159124 0.36219089205808774 0.1900476494151135 9.037306367395752e-07 8.424275324277011e-08 0.18401300432456955 0.06133761509755003 5.633879959421988e-11 10.249192410725472 -0.30380333806708937 LESLSYQLSGLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LESLSYQLSGLQK 13 0 Q03252 Q03252 LMNB2 Lamin-B2 0 13623800.0 6452700.0 4312800.0 2858300.0 False True 5365705.953078863 4289566.090376222 3455957.3147140048 1.0 0.7994411411819635 0.6440825018991141 22.355336564724215 -6.9739778024931285 0.1322330472020657 1.2328715369327174 0.2066243837768959 0.9999991594146871 0.00013345130470027888 0.07503184299013016 0.003977312979392384 0.009539063802166564 0.020989685512095554 1.0617498235955881e-07 6.9739778024931285 -1.0262471531558215 LESLSYQLSGLQK(ub)QASAAEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LESLSYQLSGLQKQASAAEDR 21 1 Q03252 Q03252 LMNB2 Lamin-B2 1 52967000.0 13107000.0 27878000.0 11982000.0 True False 17183403.928368557 23718711.06759287 10742217.5794599 1.0 1.3803266900125064 0.6251507340594651 24.034512518158333 -6.769794545710428 1.5752529148330048 1.2182097058050143 0.6209404302223139 0.7297231516291642 0.1602805262021338 0.26678719471377854 1.3064731686395363 0.08020234685136476 0.1909498737492516 1.699047240813674e-07 6.769794545710428 -0.5972692755827004 LESLSYQLSGLQK(ub)QASAAEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LESLSYQLSGLQKQASAAEDR 21 1 Q03252 Q03252 LMNB2 Lamin-B2 1 200107000.0 82115000.0 76077000.0 41915000.0 True False 79508304.27247852 106454942.83631384 30936204.076953452 1.0 1.3389160265761422 0.38909399917439685 26.244602215263193 -6.810224634310869 1.4135898888223835 1.1846556391499183 0.372391415750746 0.8604169881940787 0.14683807528515935 0.20649181511788472 0.8131961973600771 0.08167744223366047 0.18891744604301347 1.5480157167469265e-07 6.810224634310869 -0.8122642233991724 down LESLSYQLSGLQK(ub)QASAAEDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LESLSYQLSGLQKQASAAEDR 21 1 Q03252 Q03252 LMNB2 Lamin-B2 1 211481000.0 91254000.0 61021000.0 59206000.0 True False 138438989.56102008 50131325.79075087 47503908.14908839 1.0 0.3621185473089167 0.3431396624586745 27.044675075805728 LESLSYQLSGLQK(ub)QASAAEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LESLSYQLSGLQKQASAAEDR 21 1 Q03252 Q03252 LMNB2 Lamin-B2 1 59892000.0 13107000.0 23662000.0 23123000.0 True False 17953012.103356674 22616534.60022972 17661823.633133475 1.0 1.2597626777069408 0.9837805228143996 24.097722579681225 -6.6598541373381055 1.9735455037571221 1.1672292815481267 0.9849353833746459 0.2349005047118058 0.11060555964876953 0.48480793395746163 3.6298185412946466 0.04528289803215104 0.12259887618403097 2.1884965315805512e-07 6.6598541373381055 -0.18229389817348074 LESLSYQLSGLQK(ub)QASAAEDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LESLSYQLSGLQKQASAAEDR 21 1 Q03252 Q03252 LMNB2 Lamin-B2 1 210235000.0 82115000.0 107430000.0 20690000.0 True False 68282260.8112993 106851253.26681468 25016183.340248644 1.0 1.5648464476315789 0.36636430960278027 26.02500749069747 -6.778549441430079 1.541594500854867 1.3204308634341473 0.35731028058096903 0.7622067369250718 0.2387228773248239 0.25283095787221826 1.1867192528975568 0.12198132252178492 0.28816701588077626 1.6651392523800855e-07 6.778549441430079 -0.9631205828531783 down LESLSYQLSGLQK(ub)QASAAEDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LESLSYQLSGLQKQASAAEDR 21 1 Q03252 Q03252 LMNB2 Lamin-B2 1 208112000.0 91254000.0 74259000.0 42599000.0 True False 118130101.88526219 70126421.37109272 34846419.10265123 1.0 0.5936371868975898 0.29498340005240137 26.815801397898177 -7.984100239862257 0.23673209878687415 1.1925515989730469 6.764349328433044e-09 0.999694692438712 0.005048648086178115 0.10357408023096748 0.04207815347858758 0.06863525964727712 0.09687251181530739 1.0372889706756341e-08 7.984100239862257 -1.1925515922086976 down LESMSAK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LESMSAKER 9 1 Q9BXW9;Q9BXW9-1;Q9BXW9-3;H7BZJ7 Q9BXW9 FANCD2 Fanconi anemia group D2 protein 1 4314110.0 233670.0 374940.0 3705500.0 True False 302490.42132431665 354074.25940125145 3031137.0216407436 1.0 1.1705304844070712 10.020604977738765 18.206529933099407 -6.911070032957251 0.8884036900118969 0.7351694721287613 11.190947564131365 0.9913194225020918 0.3924988905805506 0.10371502516025476 0.13495592775483953 0.3230537581708612 0.898541435468776 1.2272413141407108e-07 6.911070032957251 10.455778092002603 up LETELQEATK(ub)EFQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LETELQEATKEFQIK 15 1 Q13287 Q13287 NMI N-myc-interactor 1 4299400.0 1254100.0 1339600.0 1705700.0 True False 1644137.2447216776 1139736.9017199015 1529210.5262297404 1.0 0.6932127505650163 0.9300990724096198 20.64889930265945 -9.82311406283883 5.6680332527901305 1.000000040209082 0.811655912487458 0.4573693593485081 0.09670843593089963 4.9147021672968285e-08 1.0093034524922547e-08 0.0936375599822672 0.03121251348265917 1.5027472336358422e-10 9.82311406283883 -0.188344127721624 LETMPLYLEDDIRPDIK(ub)DDIYDPTYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LETMPLYLEDDIRPDIKDDIYDPTYK 26 2 O00767 O00767 SCD Acyl-CoA desaturase 1 30689500.0 2376400.0 2401500.0 25911600.0 True False 2300962.4827755964 3360431.4736570567 19124574.62866245 1.0 1.4604460084909545 8.311554304698149 21.133806029915792 -6.920523950640131 0.8208308064560914 0.8516702568115552 9.429784702431393 0.994325220785902 0.25186661985334824 0.09786457094828346 0.10402385702743722 0.21761273992799574 0.6551552823446058 1.2008148481867083e-07 6.920523950640131 8.578114445619837 up LEVEANNAFDQYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEVEANNAFDQYR 13 0 P47756-2;B1AK88;B1AK87;P47756;B1AK85;A0A6I8PRV6 P47756-2 CAPZB F-actin-capping protein subunit beta 0 12226600.0 1870600.0 4822500.0 5533500.0 False True 2452374.714916171 4103001.7979577715 4960946.501080059 1.0 1.6730729496605592 2.0229153688895534 21.225748004326885 -9.843046305251093 0.15635386340471816 1.3640649134240683e-13 2.520208077310581 0.9997118158853472 0.007206238414327454 1.3597419564698443 0.06955877205786712 0.8622390037893399 0.2868907369215433 1.4353363870729956e-10 9.843046305251093 2.5202080773104445 LEVEANNAFDQYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEVEANNAFDQYR 13 0 P47756-2;B1AK88;B1AK87;P47756;B1AK85;A0A6I8PRV6 P47756-2 CAPZB F-actin-capping protein subunit beta 0 11814600.0 3276400.0 1665500.0 6872700.0 False True 3172392.4754106905 2330542.8354677632 5072533.693419489 1.0 0.7346325694351726 1.5989615826972388 21.597139835732357 -6.824281177409221 1.3531837298741813 0.8575520005685684 1.619630613180417 0.8939585761115294 0.11772383431893423 0.18797820001633977 0.6751383616628087 0.06834230117203394 0.157372570530812 1.4987142014295322e-07 6.824281177409221 0.7620786126118486 LEVEANNAFDQYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEVEANNAFDQYR 13 0 P47756-2;B1AK88;B1AK87;P47756;B1AK85;A0A6I8PRV6 P47756-2 CAPZB F-actin-capping protein subunit beta 0 10515700.0 1870600.0 5454200.0 3190900.0 False True 2562211.3710642424 5213215.40937254 2437275.138648344 1.0 2.0346547003291047 0.9512389048667735 21.288958065849776 -6.656643881371133 1.9852317467751164 1.6678375199792257 0.9558136181933599 0.22131321331594767 0.44089029884102554 0.4924146883503796 3.7271770930087427 0.17966855410646607 0.48845661291372733 2.2047335891300577e-07 6.656643881371133 -0.7120239017858658 LEVGTETIIDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEVGTETIIDK 11 0 Q01581;P54868-3;P54868-2;P54868 Q01581 HMGCS1;HMGCS2 Hydroxymethylglutaryl-CoA synthase, cytoplasmic;Hydroxymethylglutaryl-CoA synthase, mitochondrial 0 5957700.0 1418400.0 2262700.0 2276600.0 False True 1859536.1358051386 1925113.979935519 2041039.2706892346 1.0 1.0352657003365984 1.0976066726476972 20.826511353004285 -6.962385555288465 0.40040396981777554 0.9965882681316347 1.1385618708229734 0.9998486659833167 0.0004964118193092681 0.07885979364487446 0.01806213032626146 0.0008021032560364884 0.005222362855863079 1.0904718142265527e-07 6.962385555288465 0.14197360269133874 LEVGTETIIDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEVGTETIIDK 11 0 Q01581;P54868-3;P54868-2;P54868 Q01581 HMGCS1;HMGCS2 Hydroxymethylglutaryl-CoA synthase, cytoplasmic;Hydroxymethylglutaryl-CoA synthase, mitochondrial 0 6522000.0 1418400.0 2550500.0 2553100.0 False True 1942820.8108187302 2437810.4766243724 1950110.3627450224 1.0 1.2547788571386813 1.003752045420607 20.889721414527177 -10.78141373571054 2.5507963097635784 0.9642024617367281 1.1292654508471143 0.26120754758701215 0.1024812721860117 16608365.470393239 12285062.926856335 3712589.265581828 0.040236176383670996 1.654193325995509e-11 10.78141373571054 0.1650629891103862 LEVNLQAMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LEVNLQAMK 9 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 71548600.0 21259100.0 27143300.0 23146200.0 False True 27870885.97341728 23093625.443754718 20751253.25802827 1.0 0.8285931586739287 0.7445494656259015 24.73225552848101 -13.999999997312885 0.09342736398118251 1.8654788625312766 0.5458011270028328 0.999826098013376 0.001401796175044453 12.133654673976473 0.0896312602727939 2.0624933785932638 0.17805272533185285 1.0000000061873098e-14 13.999999997312885 -1.319677735528444 LEVNLQAMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEVNLQAMK 9 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 34819800.0 11914000.0 6191800.0 16714000.0 False True 11535796.591393871 8664218.029810442 12336101.990747927 1.0 0.7510723651519885 1.0693758244620153 23.459614295347556 -6.698032762777325 1.8375564195481204 0.8451346477085679 1.068405960307985 0.408438619970923 0.10511292778080783 0.3996060072316462 2.621790075129928 0.045655783210679604 0.11771495013842284 2.0043208175378074e-07 6.698032762777325 0.22327131259941702 LEVNLQAMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LEVNLQAMK 9 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 93631000.0 17891000.0 44171000.0 31569000.0 False True 27141955.007300597 36288339.94040179 25329373.31281574 1.0 1.3369832766519956 0.9332184548240055 24.69402130456141 -6.68524728188235 1.8833963035365786 1.2122010212321217 0.9346914305706309 0.3482563015232132 0.1426605733673176 0.4269539783314001 2.932464006015611 0.0606830587675567 0.15897074494076424 2.0642044887468296e-07 6.68524728188235 -0.27750959066149083 LEVNLQAMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEVNLQAMK 9 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 53614000.0 17027000.0 17738000.0 18849000.0 False True 23322342.03737346 16954276.50827803 14397254.407340452 1.0 0.7269542861994406 0.6173159789985593 24.47520933594232 -13.999999999999998 0.12577511638892303 2.2978105074906567 0.4552066050046981 0.9996651396039071 0.002944475028312475 11.945323526077503 0.10984749077878762 3.8484364640933393 0.14398176568588542 1.0000000000000041e-14 13.999999999999998 -1.8426039024859586 LEVNLQAMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEVNLQAMK 9 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 29478800.0 11914000.0 9037200.0 8527600.0 False True 9907018.879690904 8988514.809856247 10310681.732832493 1.0 0.9072875421972231 1.0407451381736121 23.240019570781833 -6.71985945616764 1.759660639915896 0.9435866868389454 1.040537601308046 0.5119073990012278 0.039014451052336065 0.35560057564562736 2.151770335386073 0.017604426050563105 0.04420367758843923 1.9060774517685414e-07 6.71985945616764 0.09695091446910065 LEVNLQAMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LEVNLQAMK 9 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 80003900.0 22261900.0 34145300.0 23596700.0 False True 28818468.397654 32245084.03886901 19302342.7225881 1.0 1.1189034612781141 0.6697907208753477 24.780490327488756 -6.836314849135088 1.2994922476609625 1.0633130146580592 0.6560729039770167 0.9179131067423834 0.05443473437531462 0.1731491504727614 0.5695768957404533 0.03286606981056806 0.07565484470795968 1.4577570514539539e-07 6.836314849135088 -0.4072401106810425 LEYCEALAMLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEYCEALAMLR 11 0 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 5868940.0 912140.0 2697000.0 2259800.0 False True 1195824.3731763249 2294618.1128236577 2025977.5735322556 1.0 1.9188587925572538 1.6942099684344905 20.189574090504923 -10.59251029233304 7.13125833951565 0.9989983686053744 1.8065343804958525 0.9450128143594612 0.09171249840283516 0.0014619290045728445 8.35364094999863e-05 0.08888641010909333 0.02960008157943793 2.5555813356943424e-11 10.59251029233304 0.8075360118904781 LEYCEALAMLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LEYCEALAMLR 11 0 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 5281840.0 912140.0 2522600.0 1847100.0 False True 1249382.807656653 2411143.190877335 1410853.022218607 1.0 1.929867432224143 1.1292399843926202 20.252784152027814 -10.189599068367565 4.302259640606083 0.9998316721466626 1.529553708335494 0.3684108831725901 0.32685478696769343 229537544.39719158 126.6653488577099 392751.27465563914 0.11189108739304598 6.462505588066604e-11 10.189599068367565 0.5297220361888314 LEYQIK(ub)TNQLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LEYQIKTNQLHR 12 1 Q9UBI1;H0Y4W0;R4GNF2;H0Y4E5 Q9UBI1 COMMD3 COMM domain-containing protein 3 1 3115000.0 563710.0 968290.0 1583000.0 True False 739029.2689754057 823824.9063648587 1419206.3452082293 1.0 1.1147392139245231 1.92036554543479 19.49527197733257 -6.932606907966394 0.7250744418332131 0.988855683976437 2.097299710777302 0.9970262795459178 0.02233122268553158 0.09130649135327769 0.07121325311355299 0.020670012153541525 0.07187881798599413 1.167866207051276e-07 6.932606907966394 1.108444026800865 LEYQIK(ub)TNQLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LEYQIKTNQLHR 12 1 Q9UBI1;H0Y4W0;R4GNF2;H0Y4E5 Q9UBI1 COMMD3 COMM domain-containing protein 3 1 8961580.0 889680.0 1283800.0 6788100.0 True False 861437.5953862097 1796428.034928559 5010092.97136509 1.0 2.08538383343156 5.81596739937837 19.716386762369577 -6.948359750848775 0.5765694450038271 0.9548098253183619 7.129978018783722 0.9990662026578657 0.06302911991235413 0.08415113889506694 0.038740232329362474 0.06628575839349508 0.3113507184358128 1.1262641209588764e-07 6.948359750848775 6.1751681934653595 LEYQIK(ub)TNQLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LEYQIKTNQLHR 12 1 Q9UBI1;H0Y4W0;R4GNF2;H0Y4E5 Q9UBI1 COMMD3 COMM domain-containing protein 3 1 6038280.0 889680.0 2559700.0 2588900.0 True False 739808.3395067488 2545910.3880393277 3130227.020278863 1.0 3.4413107450731877 4.23113237999706 19.496792037803854 -9.455630654902297 0.34304107979008486 1.8735248480522997e-17 4.440384017851222 0.9984417923228344 0.05429034940470876 0.821561119418431 0.1378252428608793 1.2201944564325469 0.2362242587149331 3.502429039634095e-10 9.455630654902297 4.440384017851222 LFADAVQELLPQYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFADAVQELLPQYK 14 0 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 0 10349100.0 3621700.0 2428600.0 4298800.0 False True 3506731.1159183537 3398352.6449816944 3172815.3187643443 1.0 0.9690941599586324 0.9047786140094284 21.741695383261668 -6.9592639162191325 0.4457307609165555 1.0021669790790342 0.8691744120807017 0.9997417701374138 0.0006373485021668458 0.07996575823591648 0.022115061955787964 0.000854377501929555 0.0053234913783946364 1.0983381879493012e-07 6.9592639162191325 -0.1329925669983325 LFADAVQELLPQYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFADAVQELLPQYK 14 0 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 0 9562030.0 397830.0 2527700.0 6636500.0 False True 544918.5019515059 2416017.8560138913 5069095.383007842 1.0 4.433723295064223 9.302483517909542 19.055680950890842 -6.966175466704622 0.33726938803200485 0.4549265735407755 13.442415765781424 0.9999353659567488 0.027385128860641643 0.07756431127639207 0.01346576277219903 0.0693185921845755 0.4222669058455586 1.0809971110166008e-07 6.966175466704622 12.987489192240648 LFADAVQELLPQYK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFADAVQELLPQYKER 16 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 16470300.0 2468600.0 5243000.0 8758700.0 True False 3236358.505956409 4460764.837053932 7852433.743383028 1.0 1.3783283986752533 2.4263176434041185 21.625939999748827 -6.953228398597749 0.5221998757457714 0.982489863924072 2.8691004612636446 0.9994308896053737 0.014392471687456368 0.0822147017759209 0.03079335551799713 0.016248321975453603 0.0865838613461418 1.113708672134305e-07 6.953228398597749 1.8866105973395726 up LFADAVQELLPQYK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFADAVQELLPQYKER 16 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 240921000.0 10021000.0 19534000.0 211366000.0 True False 15202589.633232329 16048005.080161404 169589417.45499134 1.0 1.055609962994793 11.155297981882956 23.857813759775233 -6.908106259983836 0.9085144005424655 0.6682598420962839 12.409079088251465 0.9901876235658656 0.4729200267817562 0.10568404814664448 0.1456507662448229 0.38359701054841816 1.0455356855088043 1.2356450678966207e-07 6.908106259983836 11.740819246155182 up LFADAVQELLPQYK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFADAVQELLPQYKER 16 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 20178500.0 2468600.0 5155900.0 12554000.0 True False 3381308.1314066006 4928095.289718723 9589003.757745886 1.0 1.457452293077079 2.8358858125588595 21.689150061271718 -6.951351740593902 0.5438066578939664 0.980198633802033 3.377211598922899 0.9993031039232623 0.020598984775794655 0.08294755892053723 0.033751556856101726 0.022539926609371683 0.11422541742472372 1.118531603619844e-07 6.951351740593902 2.397012965120866 up LFADAVQELLPQYK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFADAVQELLPQYKER 16 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 456693000.0 10021000.0 16441000.0 430231000.0 True False 12972382.043441528 15526043.89719949 351933372.5428472 1.0 1.1968537347424963 27.129433234721517 23.628940081867682 -6.908563707194029 0.9054537498187022 0.16011752206413768 30.379891637092776 0.9903680881156358 1.2043432015794608 0.10537633901023273 0.14397437164229615 0.9790569690857415 2.676508528307655 1.2343442344090195e-07 6.908563707194029 30.21977411502864 up LFAELEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFAELEIK 8 0 O75937;S4R3J5 O75937 DNAJC8 DnaJ homolog subfamily C member 8 0 49376000.0 10797000.0 24301000.0 14278000.0 False True 16379838.36643142 19964296.68542039 11455947.041730298 1.0 1.2188335585981667 0.6993931677132988 23.965417784981767 -6.792274562453563 1.4874447252648195 1.121944071667924 0.6935328857526779 0.8085570414557182 0.09316789072902354 0.2319715274012593 1.0138798134561215 0.0492981227131551 0.11522011160806163 1.6133382763839594e-07 6.792274562453563 -0.4284111859152462 LFAELEIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFAELEIK 8 0 O75937;S4R3J5 O75937 DNAJC8 DnaJ homolog subfamily C member 8 0 3973490.0 2136900.0 796290.0 1040300.0 False True 1776927.0307211261 792000.227718811 1257821.9201962634 1.0 0.44571342211919385 0.7078635748401015 20.76095300782175 -10.430129453028437 6.109479699037037 1.000139619128913 0.576788498479653 0.7765357615004913 0.1070223516931514 0.00020359488252917556 1.8990785570678406e-05 0.10365772924509446 0.03454131548162736 3.7142449963803015e-11 10.430129453028437 -0.42335112064925995 LFAELEIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFAELEIK 8 0 O75937;S4R3J5 O75937 DNAJC8 DnaJ homolog subfamily C member 8 0 35456000.0 10797000.0 13597000.0 11062000.0 False True 13976929.340688355 12840314.997276394 9048829.505705008 1.0 0.9186792523803383 0.6474118374028611 23.736544107074216 -6.949045364206577 0.5692375047337805 1.003390851823287 0.5495289064268788 0.9991241470991722 0.004461277026554739 0.08387156201236108 0.03756790556523933 0.004730569313432065 0.022597646619064535 1.1244875095502791e-07 6.949045364206577 -0.45386194539640823 LFAK(ub)EVAPVPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFAKEVAPVPK 11 1 Q15274;H3BP73 Q15274 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] 1 24488500.0 1461500.0 4538000.0 18489000.0 True False 2217202.3499619807 3728158.444444166 14834641.045983408 1.0 1.681469643268281 6.690702382774303 21.080309011141935 -6.931706498738556 0.732648256760582 0.9284410173637028 7.76523918327373 0.9968631277964156 0.14210841741592375 0.09176148013053663 0.0734097803084131 0.1308071473298953 0.44907196869563626 1.1702900194367172e-07 6.931706498738556 6.836798165910027 up LFAK(ub)EVAPVPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFAKEVAPVPK 11 1 Q15274;H3BP73 Q15274 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] 1 18215500.0 1461500.0 2656000.0 14098000.0 True False 1891940.5604719846 2508191.26518836 11532308.657695657 1.0 1.325724136155017 6.0954920564833595 20.851435333234384 -6.920720271365012 0.819355742396067 0.8974661742421948 6.877578375491854 0.9943788925150032 0.17461929541971988 0.0977499489285938 0.1034281906713523 0.15102898868589082 0.45557398826630957 1.2002721483007228e-07 6.920720271365012 5.98011220124966 up LFAK(ub)YGEPGEVFINK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFAKYGEPGEVFINK 15 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 8357800.0 2653300.0 3071500.0 2633000.0 True False 3478501.994593752 2613244.1726132245 2360562.4175194395 1.0 0.7512556199981195 0.6786146511309175 21.73003471727941 -13.999999999999998 0.17257056738618795 2.263089911093965 0.6162595634528547 0.9995090082773818 0.003049295872964124 12.117553016301486 0.1315959840793976 5.125086708922091 0.0578653156586041 1.0000000000000041e-14 13.999999999999998 -1.6468303476411104 LFAK(ub)YGEPGEVFINK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFAKYGEPGEVFINK 15 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 13384600.0 3961400.0 4020100.0 5403100.0 True False 3835647.5253607268 5625346.894544546 3987866.020474463 1.0 1.4665964109972554 1.0396852145843147 21.87103872013429 -10.236869344517208 3.5954577020942806 0.9995466372542138 1.2531408128064163 0.3191722977809959 0.17428576706422616 33357727.44033293 49105854.599507935 164216.37166859434 0.06873798100997167 5.796030410897819e-11 10.236869344517208 0.25359417555220254 LFAK(ub)YGEPGEVFINK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFAKYGEPGEVFINK 15 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 38709500.0 12897000.0 7946500.0 17866000.0 True False 19565691.896996032 6528384.988712122 14334777.269054035 1.0 0.3336649183213623 0.7326486251812484 24.221822793040342 -10.818908451487246 6.994905866387973 1.025261127363773 0.5331567717516377 0.6460743923026486 0.16288441624848354 0.058035984758123084 0.0015024955144971686 0.14264171735282488 0.05257071929059114 1.5173701927160468e-11 10.818908451487246 -0.4921043556121354 LFAK(ub)YGEPGEVFINK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFAKYGEPGEVFINK 15 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 10634500.0 2653300.0 3326900.0 4654300.0 True False 3634296.7127364213 3179906.5574129107 3555050.1983174016 1.0 0.8749716406667907 0.9781948143800974 21.7932447788023 -10.42547442922536 7.0502337650543 1.0000065351473288 0.926583227523444 0.4028028949511564 0.04214068420471182 4.329133579061548e-06 3.5278038516038964e-07 0.04080617350118148 0.013600847343552887 3.7542705854776487e-11 10.42547442922536 -0.07342330762388483 LFAK(ub)YGEPGEVFINK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFAKYGEPGEVFINK 15 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 10415200.0 3961400.0 3734600.0 2719200.0 True False 3294079.619775689 3714480.9685399435 3287772.147839738 1.0 1.1276233113008 0.9980852096293955 21.651443995568567 -6.649517579508718 2.009695613459834 1.0828420985016511 0.9986229000100411 0.19237852287978374 0.05447654972162428 0.5096682231104082 3.9449129658200643 0.021985121913593836 0.060359371958347105 2.241209323569857e-07 6.649517579508718 -0.08421919849161008 LFAK(ub)YGEPGEVFINK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFAKYGEPGEVFINK 15 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 39922000.0 12897000.0 10909000.0 16116000.0 True False 16695420.737876987 10301904.5602183 13183053.364124216 1.0 0.6170497121313221 0.7896209128899492 23.99294911513279 -10.05318082764256 4.911879473044145 1.0000062772931015 0.703335312624656 0.7975848200391489 0.07045189770326135 5.1163540564469565e-06 9.862309567304325e-07 0.0682162809710036 0.022738252207987777 8.847471500423338e-11 10.05318082764256 -0.29667096466844556 LFAK(ub)YYDDTYPSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFAKYYDDTYPSVK 14 1 F8VVA7;P61923;P61923-4;P61923-5;F8VXB1;F8VUC5;F8W156;F8VXR1;F8VYZ4 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 8020500.0 1630800.0 1560200.0 4829500.0 True False 2137994.5926896674 1327424.2416119657 4329789.667835215 1.0 0.6208735261308694 2.0251639936975696 21.027826773594146 -6.834811539637092 1.3061858704337042 0.7979879421242457 2.0668286769452804 0.9151718383584967 0.17276440872584642 0.17494932603673427 0.5820200162379129 0.10379150195155244 0.2388956280205512 1.4628118181159894e-07 6.834811539637092 1.2688407348210347 up LFAK(ub)YYDDTYPSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFAKYYDDTYPSVK 14 1 F8VVA7;P61923;P61923-4;P61923-5;F8VXB1;F8VUC5;F8W156;F8VXR1;F8VYZ4 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 11015700.0 2250800.0 2902000.0 5862900.0 True False 2179349.586025633 4060783.733730082 4327230.606770133 1.0 1.8633007571472382 1.9855605702348467 21.055466204774188 -10.997048951174133 0.3605896989998572 2.76286014368088e-13 2.0036209762683588 0.9993968759316997 0.010772126616142791 2.8180841003404624 0.17912531329279532 2.3761899359731626 0.03511264239834227 1.0068181797061902e-11 10.997048951174133 2.0036209762680826 LFAK(ub)YYDDTYPSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFAKYYDDTYPSVK 14 1 F8VVA7;P61923;P61923-4;P61923-5;F8VXB1;F8VUC5;F8W156;F8VXR1;F8VYZ4 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 7949900.0 1630800.0 1552100.0 4767000.0 True False 2233750.8307129084 1483523.0898916645 3641132.779446758 1.0 0.6641399163657808 1.6300532402195813 21.091036835117038 -6.812784989583292 1.4027839159894475 0.8175543613852577 1.6480522289111972 0.8669834852156393 0.14602533700468934 0.2030227897672741 0.7868500027876776 0.08183957024324415 0.18908520309045246 1.5389163380995303e-07 6.812784989583292 0.8304978675259395 LFAK(ub)YYDDTYPSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFAKYYDDTYPSVK 14 1 F8VVA7;P61923;P61923-4;P61923-5;F8VXB1;F8VUC5;F8W156;F8VXR1;F8VYZ4 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 10267100.0 2250800.0 3948900.0 4067400.0 True False 1871639.9273466794 3927626.491904724 4917874.534467251 1.0 2.09849471285468 2.627575134838596 20.835871480208464 -9.469482680740485 0.20909854026198044 4.208653260744023e-14 3.1005643915777927 0.9994168587161688 0.016369514435743363 0.894611340499723 0.08268615361161885 0.8592706139382212 0.2884766107217186 3.3924801816673684e-10 9.469482680740485 3.1005643915777505 LFAK(ub)YYDDTYPSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFAKYYDDTYPSVK 14 1 F8VVA7;P61923;P61923-4;P61923-5;F8VXB1;F8VUC5;F8W156;F8VXR1;F8VYZ4 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 36708600.0 2258600.0 11942000.0 22508000.0 True False 2923802.223662009 11277417.202138323 18411774.951582775 1.0 3.8571067190767656 6.297202595503317 21.479414294912676 -7.5816260605002554 0.25680005479912466 3.2116721306541424e-19 8.717682349450289 0.9997903844405723 0.031342296928246985 0.13683907951260948 0.03072375873068589 0.2556143816482874 0.5828103822037162 2.620438306633345e-08 7.5816260605002554 8.717682349450289 LFALVLTPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFALVLTPTR 10 0 Q9H0S4;Q9H0S4-2 Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 0 14238800.0 5464500.0 7146700.0 1627600.0 False True 7164012.418293276 6080440.217618407 1459191.5650416403 1.0 0.8487478611974524 0.20368356164704582 22.772336407456898 -6.943404557822882 0.6270924705374783 1.007038265001356 0.010800664321242513 0.9985766713175414 0.013027240131400927 0.08624725703391904 0.04779079634067815 0.013035813434510438 0.054741589213018256 1.1391881066008989e-07 6.943404557822882 -0.9962376006801136 down LFALVLTPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFALVLTPTR 10 0 Q9H0S4;Q9H0S4-2 Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 0 6937700.0 4542000.0 2395700.0 0.0 False True 4397816.696165099 3352315.503410459 0.0 1.0 0.7622681287134323 0.0 22.068356042310878 -7.3127229879121 0.8104946184995877 0.9890540926429107 2.908409055291904e-19 0.9881593923386629 0.04641577011738677 0.1052246669725027 0.13752030296207496 0.0396450386640079 0.07026457459125973 4.867175565297335e-08 7.3127229879121 -0.9890540926429107 down LFALVLTPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFALVLTPTR 10 0 Q9H0S4;Q9H0S4-2 Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 0 22424200.0 5464500.0 7770000.0 9189700.0 False True 7484873.322559894 7426695.708046023 7019282.1278124275 1.0 0.9922273080643168 0.9377957148126816 22.83554646897979 -6.932661954277998 0.7246353499156354 1.0007515389349717 0.9258250021925706 0.9970355728780607 0.0015067356289583823 0.09127929853130354 0.07108710834392308 0.0013951133956741902 0.004855054067296248 1.1677181907723164e-07 6.932661954277998 -0.07492653674240113 LFALVLTPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFALVLTPTR 10 0 Q9H0S4;Q9H0S4-2 Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 0 9562700.0 4542000.0 2387200.0 2633500.0 False True 3776874.2447168124 2374339.6797779026 3184152.674071762 1.0 0.6286520349728851 0.8430655795664458 21.848761317745154 -10.205159648988882 5.421145422261434 1.0000129685375618 0.7358588072696314 0.6692591967089678 0.08753396303273814 1.3720881305728061e-05 2.011620088046975e-06 0.08475855453979894 0.028251465087760205 6.235055893386496e-11 10.205159648988882 -0.26415416126793045 LFALVLTPTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFALVLTPTR 10 0 Q9H0S4;Q9H0S4-2 Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 0 27046200.0 9194200.0 10020000.0 7832000.0 False True 11902073.144776959 9462378.191712111 6406656.36310628 1.0 0.7950193278609222 0.5382807083417851 23.504709553306903 -6.968080401364078 0.3005222991559663 1.0442515928390594 0.28099777822090205 0.9999632979823797 0.001144325294427617 0.07693063551642065 0.011247813002329732 0.004248375279096803 0.02301302241015404 1.0762659450133026e-07 6.968080401364078 -0.7632538146181573 LFCTDK(ub)NER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFCTDKNER 9 1 Q9UKV8-2;Q9UKV8 Q9UKV8-2 AGO2 Protein argonaute-2 1 3564870.0 1304300.0 1377500.0 883070.0 True False 1709949.9308591678 1171982.369452946 791698.3874055789 1.0 0.6853898750497806 0.46299506969060106 20.70552265141855 -7.869775339897474 0.14802057451431327 1.3438655263594996 3.55598246065389e-16 0.9999631390549037 0.0013375371301592928 0.12240570340416275 0.02182457943053858 0.07724034908512745 0.10236796197639675 1.349660880267177e-08 7.869775339897474 -1.3438655263594992 down LFCTDK(ub)NER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFCTDKNER 9 1 Q9UKV8-2;Q9UKV8 Q9UKV8-2 AGO2 Protein argonaute-2 1 6944000.0 1601400.0 2544300.0 2798300.0 True False 2429440.878021979 2090249.7862933644 2245214.7784615397 1.0 0.8603830639398891 0.9241693423260278 21.212192893311645 -10.176683768459373 4.817509687236106 1.000011559413362 0.8922762031333905 0.7917896445214201 0.02604063910767122 3.2561190490315537e-06 5.564956095867678e-07 0.025216464545308126 0.008404580132173482 6.657577512788564e-11 10.176683768459373 -0.10773535627997155 LFCTDK(ub)NER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFCTDKNER 9 1 Q9UKV8-2;Q9UKV8 Q9UKV8-2 AGO2 Protein argonaute-2 1 2569150.0 1266100.0 529300.0 773750.0 True False 1052818.2477401933 526448.5558421764 935537.5475842141 1.0 0.5000374537316051 0.8886030894622936 20.005824968920432 -9.84464387483768 6.420057460881147 1.0000000116899843 0.6943202715969008 0.4521057196486643 0.15863125652023696 2.6503266095747203e-08 4.990955239689471e-09 0.15359406053881414 0.05119801789087644 1.430066144223827e-10 9.84464387483768 -0.3056797400930835 LFCTDK(ub)NER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFCTDKNER 9 1 Q9UKV8-2;Q9UKV8 Q9UKV8-2 AGO2 Protein argonaute-2 1 5768100.0 1601400.0 2426500.0 1740200.0 True False 2073043.868313268 2291463.141935075 1423501.45595985 1.0 1.105361626427869 0.6866721335318783 20.983319215404094 -6.840042641901393 1.282294366709141 1.0560479878479512 0.672897768204864 0.924511941332009 0.04885592576024036 0.16874947881659505 0.5389878022405656 0.029876337640120033 0.0688263110853219 1.445297854887193e-07 6.840042641901393 -0.38315021964308715 LFCVGFTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFCVGFTK 8 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6;H0Y8L7;D6RAS7 P61247 RPS3A 40S ribosomal protein S3a 0 245950000.0 78779000.0 101800000.0 65371000.0 False True 103280031.8969212 86611836.81329207 58607036.0029104 1.0 0.838611638886161 0.5674575707083751 26.621986110417474 -6.963304244049853 0.3860514688683257 1.0174037046675768 0.3789839966229433 0.9998738080255081 0.002004837384768363 0.0785412192077427 0.016918841154481883 0.003509941202241384 0.02284822678334886 1.0881675128803636e-07 6.963304244049853 -0.6384197080446334 LFCVGFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFCVGFTK 8 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6;H0Y8L7;D6RAS7 P61247 RPS3A 40S ribosomal protein S3a 0 204902000.0 80178000.0 60150000.0 64574000.0 False True 121635887.79695639 49415762.54590496 51810920.59621042 1.0 0.4062597268036009 0.42595093877801127 26.85799370751858 -10.409927696098384 9.273003967837736 1.0000019705692391 0.41610533281777934 0.999147749864069 0.008038903625714583 3.2750389768921884e-07 2.083819272778987e-08 0.0077836611649006815 0.002594544988679918 3.891099209119376e-11 10.409927696098384 -0.5838966377514598 LFCVGFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFCVGFTK 8 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6;H0Y8L7;D6RAS7 P61247 RPS3A 40S ribosomal protein S3a 0 250756000.0 78779000.0 64547000.0 107430000.0 False True 107905725.2224258 61695100.11161472 82057246.59030113 1.0 0.5717500158999234 0.7604531309266188 26.685196171940365 -10.25710019962118 5.586530459565989 1.000023625554445 0.6661015734132616 0.8067463631382789 0.07703772411488762 2.2670439485961015e-05 3.014678968867672e-06 0.07459672628831508 0.02486381854388524 5.5322245602651456e-11 10.25710019962118 -0.3339220521411834 LFCVGFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFCVGFTK 8 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6;H0Y8L7;D6RAS7 P61247 RPS3A 40S ribosomal protein S3a 0 73099500.0 41361000.0 6274500.0 25464000.0 False True 34393504.10297934 6240698.023109267 30788404.667766634 1.0 0.18144990415700812 0.895180804362984 25.035632773227036 -10.864775521895533 10.118641404169962 1.019772310797424 0.5383153542616848 0.35811252030059904 0.2913794198603237 0.11181427933424593 0.0014942715778894261 0.24271755668180076 0.0940423033788843 1.3652886445504117e-11 10.864775521895533 -0.48145695653573917 LFCVGFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFCVGFTK 8 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6;H0Y8L7;D6RAS7 P61247 RPS3A 40S ribosomal protein S3a 0 279246000.0 80178000.0 106250000.0 92818000.0 False True 103792001.54466155 100337094.09874354 75926076.393105 1.0 0.9667131629171698 0.7315214589096648 26.62912002961103 -6.932482218403466 0.7261259720925067 1.0032678784171627 0.6800366330260331 0.9970040240008493 0.006540423327554998 0.0913693157259909 0.0715147076916138 0.006049171145379134 0.020997885595534733 1.1682015593052122e-07 6.932482218403466 -0.3232312453911296 LFDANK(ub)DR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFDANKDR 8 1 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 1 2685510.0 989980.0 816400.0 879130.0 True False 958553.6267876541 1142392.7774697558 648859.479665325 1.0 1.1917880706353294 0.6769151579341582 19.8704996209222 -6.805829605087222 1.4319634951806999 1.1050491392695094 0.6687392762349036 0.8486680559115996 0.08265067416574504 0.21254114938962448 0.8596991698691996 0.04539434453046553 0.10522000863299552 1.5637610620503257e-07 6.805829605087222 -0.43630986303460584 LFDANK(ub)DR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFDANKDR 8 1 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 1 6995700.0 2013900.0 1532900.0 3448900.0 True False 3055233.5358114485 1259342.0183976355 2767223.403293429 1.0 0.4121917371082938 0.90573220372775 21.54285123024541 -10.183693040777019 7.750875767739344 1.0000001605864801 0.6589619704180298 0.3889947632871511 0.20148705177213022 5.589341962953329e-07 5.888465980760258e-08 0.19508908911451442 0.06502966633249099 6.55099034294477e-11 10.183693040777019 -0.3410381901684503 LFDANK(ub)DR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFDANKDR 8 1 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 1 2431830.0 783680.0 638150.0 1010000.0 True False 1073427.6741556833 609954.4229201499 771458.8016029411 1.0 0.5682305735222604 0.7186872671321249 20.033793557305103 -10.29291489078504 6.39992878239735 1.0000106369038415 0.6434589203271925 0.882179202266035 0.061423687955072755 9.322648195581336e-06 1.0300961369446849e-06 0.05947500245568319 0.01982441004271977 5.094306950250975e-11 10.29291489078504 -0.35655171657664897 LFDANK(ub)DR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFDANKDR 8 1 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 1 3184290.0 989980.0 1640400.0 553910.0 True False 823212.2335501432 1631562.8396060953 669730.0200095269 1.0 1.9819467849377073 0.8135569330903688 19.650904896356476 -6.683846288915382 1.8881228718868974 1.6191510934023845 0.8178601392385589 0.34172432179067935 0.41583111372858766 0.4301122915316354 2.9677715072619644 0.17650176853772376 0.46324709283347193 2.070874169499817e-07 6.683846288915382 -0.8012909541638256 LFDAPLSISK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFDAPLSISKR 11 1 Q9NQA3;C4AMC7;Q6VEQ5;A8K0Z3;A8MWX3 Q9NQA3 WASH6P;WASH3P;WASH2P;WASH1;WASH4P WAS protein family homolog 6;Putative WAS protein family homolog 3;WAS protein family homolog 2;WAS protein family homolog 1;Putative WAS protein family homolog 4 1 8489700.0 1334600.0 2146700.0 5008400.0 True False 1727666.0088990172 2027234.257899039 4096922.590523689 1.0 1.1733947692765723 2.3713626183654086 20.72039291305399 -6.932929160955457 0.7223477758304224 0.9836146017645241 2.6367057341741473 0.9970832230743387 0.03292927442939698 0.09114513025140498 0.07043753907511706 0.03054102940541562 0.10670327359150356 1.1669999543167934e-07 6.932929160955457 1.6530911324096231 up LFDHPESPTPNPTEPLFLAQAEVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFDHPESPTPNPTEPLFLAQAEVYK 25 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 5707800.0 2138400.0 2431200.0 1138200.0 False True 2803463.108295056 2068474.4367433747 1020429.9823853485 1.0 0.7378283062199205 0.36398908884017006 21.418778654348674 -6.96608511347513 0.33891304876319095 1.0410621855641784 0.04835193663159179 0.9999337970477543 0.002123469008939607 0.07759464319143113 0.013572137136332924 0.0052949801841862465 0.03238328729947732 1.0812220315369334e-07 6.96608511347513 -0.9927102489325866 down LFDHPESPTPNPTEPLFLAQAEVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFDHPESPTPNPTEPLFLAQAEVYK 25 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 11153900.0 3477800.0 2205800.0 5470300.0 False True 3367399.142651477 3086587.443095039 4037464.3245176766 1.0 0.9166087274895106 1.1989859691353941 21.683203305338235 -6.8276004135879305 1.3385089066781257 0.9553607158450669 1.2062232828291577 0.9010016910533772 0.03727099323437063 0.18379483940776403 0.6448268372831168 0.02186756479311927 0.05033331161630608 1.487303453654944e-07 6.8276004135879305 0.2508625669840908 LFDHPESPTPNPTEPLFLAQAEVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFDHPESPTPNPTEPLFLAQAEVYK 25 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 5397500.0 2138400.0 1015000.0 2244100.0 False True 2929024.2680871203 970153.9438438496 1714089.798690261 1.0 0.3312208623240378 0.5852084659611559 21.481988715871566 -10.295731233663185 5.676860606362675 1.0000544241469014 0.45821466414271317 0.8584956159285976 0.10369000498388725 7.143012433562044e-05 8.861742687782676e-06 0.10040744783688468 0.03346580520589364 5.061377921998625e-11 10.295731233663185 -0.5418397600041882 LFDHPESPTPNPTEPLFLAQAEVYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFDHPESPTPNPTEPLFLAQAEVYK 25 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 10036500.0 3477800.0 3043600.0 3515100.0 False True 2891944.792663178 3027203.522692704 4250091.158013923 1.0 1.0467708548146133 1.4696308065065222 21.46360858077251 -6.927892585637452 0.7638809158914495 0.9930423689612192 1.5519628931280636 0.9961079305294361 0.013177694358613044 0.09374634071416825 0.08314617429472151 0.011858453569189943 0.038714163071532984 1.1806126012970914e-07 6.927892585637452 0.5589205241668443 LFDIRPIWSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFDIRPIWSR 10 1 Q9Y5Q8;Q9Y5Q8-3;Q9Y5Q8-2;H7BY84;Q5T7U0;Q5T7U4 Q9Y5Q8 GTF3C5 General transcription factor 3C polypeptide 5 0 3775420.0 1315300.0 1590400.0 869720.0 False True 1724371.0373833182 1353118.5193306445 779729.7173433371 1.0 0.784702648093627 0.45218210027846084 20.717638805583256 -6.964767171747745 0.3620269605223353 1.0279979272103006 0.19745576313845653 0.9999082634512679 0.002158338060413982 0.0780400694098076 0.015139139497557432 0.004443429243504323 0.028367386957928085 1.0845081704725245e-07 6.964767171747745 -0.830542164071844 down LFDIRPIWSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFDIRPIWSR 10 1 Q9Y5Q8;Q9Y5Q8-3;Q9Y5Q8-2;H7BY84;Q5T7U0;Q5T7U4 Q9Y5Q8 GTF3C5 General transcription factor 3C polypeptide 5 0 3767100.0 1315300.0 1089100.0 1362700.0 False True 1801601.954645992 1040979.9608279185 1040858.325687454 1.0 0.5778079659291151 0.5777404509377204 20.780848867106148 LFDIRPIWSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFDIRPIWSR 10 1 Q9Y5Q8;Q9Y5Q8-3;Q9Y5Q8-2;H7BY84;Q5T7U0;Q5T7U4 Q9Y5Q8 GTF3C5 General transcription factor 3C polypeptide 5 0 2439230.0 944760.0 1026600.0 467870.0 False True 785609.7999644775 1021069.5020358537 565699.45381354 1.0 1.299715841225533 0.7200768802007294 19.583453400871456 -6.766195756171514 1.5891863643315853 1.1727487235577323 0.717289902223402 0.7156957998584256 0.12619959543348575 0.27264720103761925 1.3583384244096657 0.06261836781085048 0.14957365454314053 1.7131849234936955e-07 6.766195756171514 -0.45545882133433024 LFDSTTLEHQK(ub)TFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFDSTTLEHQKTFR 14 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 24704700.0 2992700.0 5671000.0 16041000.0 True False 3923458.6813480244 4824908.905384861 14381231.196137212 1.0 1.2297590715870916 3.665447342291394 21.903694576323083 -6.925261388922709 0.7847158897891808 0.9557453440652645 4.1100489316679285 0.9955221031629052 0.08070217011798726 0.09517388105105629 0.09028956639839644 0.07154728634716222 0.22640041218187118 1.1877871185427974e-07 6.925261388922709 3.154303587602664 up LFDSTTLEHQK(ub)TFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFDSTTLEHQKTFR 14 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 51256400.0 5436000.0 8492400.0 37328000.0 True False 5263437.155515959 11883459.607280934 27550676.98400375 1.0 2.2577375308504153 5.234350894667999 22.327573792371382 -6.956625360913724 0.4806380197789746 0.9289801546441727 6.687345273633956 0.9996238458318719 0.03443543469260199 0.08092935991976645 0.025758285072487737 0.04202386444240611 0.24554009061291798 1.1050314514043857e-07 6.956625360913724 5.758365118989783 LFDSTTLEHQK(ub)TFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFDSTTLEHQKTFR 14 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 493327000.0 15168000.0 54059000.0 424100000.0 True False 23010964.929335184 44411749.08510513 340276449.1103668 1.0 1.9300254996472344 14.787578450331324 24.455818146234144 -6.921453674586335 0.8138798183630719 0.7308975254502347 16.931874093503904 0.9945751541651252 0.46341225891181487 0.09732390283048642 0.10123959668833855 0.40238162768762525 1.2225823282084727 1.1982469312250016e-07 6.921453674586335 16.20097656805367 up LFDSTTLEHQK(ub)TFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFDSTTLEHQKTFR 14 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 29557100.0 2992700.0 5054900.0 21509500.0 True False 4099182.0646765465 4831557.803681057 16429399.102057913 1.0 1.1786638718283668 4.007970088382573 21.966904637845975 -6.919777576496553 0.8263801491408564 0.9370695586868043 4.461886523669271 0.9941187097342259 0.10566221924356158 0.09830313741427871 0.10629587610598101 0.09093132295752403 0.27180385939030555 1.202880330899363e-07 6.919777576496553 3.5248169649824668 up LFDSTTLEHQK(ub)TFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFDSTTLEHQKTFR 14 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 38044100.0 5436000.0 7883500.0 24724600.0 True False 4520274.855632012 7841030.020747766 29894399.546365958 1.0 1.7346356739741782 6.613403056479894 22.10797906780566 -6.933726466106782 0.7155413879481944 0.935078017366402 7.71717444769447 0.9972213070135126 0.1313166426635475 0.09074855503871655 0.06853567957561855 0.1224076737584341 0.4327558246755544 1.1648594677521857e-07 6.933726466106782 6.7820964303280675 LFDSTTLEHQK(ub)TFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFDSTTLEHQKTFR 14 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 593527000.0 15168000.0 44709000.0 533650000.0 True False 19635275.005979545 42220904.847630404 436531175.7113975 1.0 2.150257882039994 22.231986849099915 24.226944468326593 -6.918680267981333 0.8344654200101502 0.5354834144181952 25.373950107492735 0.9938062217229862 0.7672558883090894 0.09895442489038009 0.10968686949729937 0.6564907834313798 1.942337206692675 1.2059234267464533e-07 6.918680267981333 24.83846669307454 up LFDTQQFLSELQAFAHHGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFDTQQFLSELQAFAHHGR 19 0 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 0 307776000.0 132200000.0 28436000.0 147140000.0 False True 128003383.36262153 39790643.09178101 108599619.89461848 1.0 0.3108561824421302 0.8484121047563719 26.93160670288641 -10.12083122136803 7.251805443396689 1.0000001770380063 0.5796341435995304 0.44914330725534946 0.2194562863135144 6.282053978716979e-07 7.597264458726889e-08 0.21248772418308096 0.07082921184273067 7.57127078001112e-11 10.12083122136803 -0.4203660334384759 LFDTQQFLSELQAFAHHGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFDTQQFLSELQAFAHHGR 19 0 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 0 143693000.0 42532000.0 39168000.0 61993000.0 False True 64524153.50570172 32178164.379019238 49740056.37750283 1.0 0.498699519958457 0.7708749929297021 25.94333597389557 -10.08566997949048 5.275120963462757 1.0000054871200812 0.634787256443657 0.705940368776935 0.11111517154818776 7.17051918825492e-06 1.243034094726822e-06 0.10758841774676718 0.03586226740954531 8.209751666344387e-11 10.08566997949048 -0.3652182306764242 LFDTQQFLSELQAFAHHGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFDTQQFLSELQAFAHHGR 19 0 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 0 313500000.0 132200000.0 91411000.0 89889000.0 False True 109930157.45300823 90918550.79933703 108684374.30022295 1.0 0.8270574054094475 0.9886675032434314 26.712011978320685 -10.490947464670082 7.276577476574103 1.000018208594597 0.9078624543317471 0.3023512878415531 0.0659770461624216 1.9493221632965318e-05 1.3638055559350548e-06 0.06389461908771414 0.02129400008491806 3.228884686801339e-11 10.490947464670082 -0.09215575426284994 LFDTQQFLSELQAFAHHGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFDTQQFLSELQAFAHHGR 19 0 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 0 77941000.0 42532000.0 17672000.0 17737000.0 False True 55058512.43106024 16688537.665063493 14509047.996988777 1.0 0.3031054950124109 0.26352052310087054 25.71446229598802 -13.6393856491742 0.41149039556186623 9.999999999769486 0.26176797356566406 0.9998473874438263 0.004178440829142527 20.92938381039436 0.21239041929023408 167.00363309040176 0.009822663172394063 2.2941105960022196e-14 13.6393856491742 -9.738232026203821 LFDYFPKPYPNSEAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFDYFPKPYPNSEAAR 16 1 P08574 P08574 CYC1 Cytochrome c1, heme protein, mitochondrial 0 8273700.0 1950200.0 1832200.0 4491300.0 False True 2556731.0857636626 1558842.9018596646 4026583.3595917365 1.0 0.6097015484106176 1.5748951393490207 21.285868996764453 -6.796949075134039 1.4684617892106901 0.7838149745893003 1.5872179806180164 0.8230557067910488 0.16675876550379665 0.2251431650794886 0.9587904735941299 0.08935351848824756 0.20818996821211477 1.5960662891416948e-07 6.796949075134039 0.8034030060287162 LFDYFPKPYPNSEAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFDYFPKPYPNSEAAR 16 1 P08574 P08574 CYC1 Cytochrome c1, heme protein, mitochondrial 0 5040100.0 1950200.0 3089900.0 0.0 False True 2671241.642173354 2953378.001067106 0.0 1.0 1.1056199313605348 0.0 21.349079058287344 -6.957295651198193 1.1911892523171834 1.0614060114666415 8.963571934819223e-20 0.9741481723611283 0.08009811708675435 0.10472379343754318 0.29476033169207994 0.056039929605645904 0.10586997656989579 1.1033272608639806e-07 6.957295651198193 -1.0614060114666415 down LFEFAGYDVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFEFAGYDVLR 11 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 3013240.0 419940.0 1197200.0 1396100.0 False True 575203.1664517892 1144303.745389021 1066369.9335820463 1.0 1.989390552989821 1.8539013617746216 19.133712092167638 -10.72373963677644 7.0387316887570375 0.9895277126702303 1.9216459573822213 0.9840500432931156 0.05531323068993661 0.008935605245419646 0.00035070954111294974 0.05264677540067812 0.017852268440587786 1.889123555264897e-11 10.72373963677644 0.932118244711991 LFEGNALLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFEGNALLR 9 0 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 0 42039000.0 10642000.0 15538000.0 15859000.0 False True 13951765.05727461 13219790.966649609 14218062.810269933 1.0 0.9475353772357755 1.0190870296268695 23.73394431517592 -6.71017463540774 1.7945888824696363 0.9677518611606434 1.018919818888411 0.46594523846397307 0.02210765760788203 0.3747161054209728 2.352545351829718 0.009803034737996718 0.024898992279758152 1.9490606997363843e-07 6.71017463540774 0.05116795772776761 LFEGNALLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFEGNALLR 9 0 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 0 19696500.0 8900600.0 2569500.0 8226400.0 False True 8618055.324942116 3595514.749765485 6071659.053289981 1.0 0.4172072021119956 0.7045277413939973 23.038930929406657 -10.498169726504209 6.315664610344981 1.0002973061612606 0.5608674717530129 0.7569606065674768 0.11729811897703246 0.0004913620066226318 3.904256601886644e-05 0.11364817389264252 0.03785780511162522 3.175632759962523e-11 10.498169726504209 -0.4394298344082477 LFEGNALLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFEGNALLR 9 0 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 0 30941000.0 10642000.0 10021000.0 10278000.0 False True 14576634.989236427 9578239.08498446 7850548.082054496 1.0 0.6570953510228632 0.5385706706555691 23.79715437669881 -13.999999999999998 0.14819364276019886 2.65364845933383 0.40542245854713144 0.9995723803587666 0.004046061211245099 11.951378953943314 0.12114227529912866 5.694234342622363 0.11980848097076234 1.0000000000000041e-14 13.999999999999998 -2.2482260007866985 LFEGNALLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFEGNALLR 9 0 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 0 16695500.0 8900600.0 4945500.0 2849400.0 False True 7401243.263436034 4918857.60989511 3445196.365862951 1.0 0.664598829523072 0.46548887034737396 22.819336204840933 -9.589839977547305 0.11573648445062709 1.686384133153078 4.2501963696233253e-13 0.9999086185252558 0.002108455050888534 1.0617987621073477 0.04713099192917019 0.453600822195358 0.22741307746583822 2.571343058966868e-10 9.589839977547305 -1.686384133152653 LFEISDIVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFEISDIVIK 10 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 1232800.0 0.0 0.0 1232800.0 False True 0.0 0.0 1105241.681852625 0.0 LFEK(ub)YGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFEKYGK 7 1 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7;C9J4X2 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 15064800.0 5157200.0 5072300.0 4835300.0 True False 6761139.142395843 4315532.611670538 4334989.539472749 1.0 0.6382848394007918 0.641162598221078 22.68883490704931 -10.068429267207781 5.036517363858603 1.0000073242557364 0.6397237188093157 0.9999521492864006 0.001174840124371117 9.66238314815651e-08 1.78717206969536e-08 0.0011375571859990727 0.00037917801887350544 8.542219617452061e-11 10.068429267207781 -0.3602836054464207 LFEK(ub)YGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFEKYGK 7 1 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7;C9J4X2 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 16621000.0 4895500.0 4986300.0 6739200.0 True False 4740095.032161215 6977355.593210981 4974001.348333644 1.0 1.4719864361094257 1.0493463347433734 22.176484552720567 -10.012297013372706 5.749753720580831 0.9999994541969216 1.2606663854264804 0.33651195308228354 0.17254209886445093 1.2071414465652112e-06 2.078234965801242e-07 0.16706351985745901 0.05568772295176591 9.720821907805644e-11 10.012297013372706 0.26066693122955875 LFEK(ub)YGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFEKYGK 7 1 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7;C9J4X2 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 16668000.0 5157200.0 4934700.0 6576100.0 True False 7063956.208089649 4716668.637129305 5022960.619030793 1.0 0.6677092125412346 0.7110690484290509 22.7520449685722 -10.847404316031207 10.956195052276307 1.00661223943942 0.6893891304851427 0.9855953759596005 0.017701578875994675 0.002840921955393954 3.956772044616394e-05 0.017030776131470048 0.005713160015692025 1.4210052549342315e-11 10.847404316031207 -0.3172231089542772 LFEK(ub)YGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFEKYGK 7 1 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7;C9J4X2 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 21383200.0 4895500.0 9996500.0 6491200.0 True False 4070825.1574220946 9942646.870350119 7848479.908082258 1.0 2.442415600243179 1.9279825599418312 21.956889828154843 -9.93960451921119 5.932949956735122 0.9999993939891636 2.185199080092928 0.8761952631409542 0.21001640926265655 1.683702505437394e-06 3.0081814526703196e-07 0.20334761688502553 0.06778250462515917 1.1491996387209082e-10 9.93960451921119 1.1851996861037646 LFEK(ub)YGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFEKYGK 7 1 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7;C9J4X2 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 43696800.0 7560300.0 9236500.0 26900000.0 True False 9786957.385792933 8722480.655463962 22004476.01730834 1.0 0.8912351726519009 2.2483469734169637 23.2224289872041 -6.887501493536051 1.0370872869632963 0.9226530697517664 2.3594976811204313 0.9792489090261244 0.088695317565201 0.12119217497139022 0.2338958683843081 0.0653704201621084 0.16156483280020897 1.2956822416661025e-07 6.887501493536051 1.4368446113686648 up LFEMAYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFEMAYK 7 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 7235000.0 2737800.0 2416000.0 2081200.0 False True 3589282.3128929124 2055542.2174942386 1865857.3882800797 1.0 0.572688921713015 0.5198413570249993 21.775263971272405 -13.999999999999998 0.29477446911964367 4.783034028963857 0.5061206541554609 0.9996381503966566 0.004089381972777761 16.25615693425315 0.17228803198237716 37.396266699866025 0.019538554209075392 1.0000000000000041e-14 13.999999999999998 -4.276913374808396 LFEMAYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFEMAYK 7 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 6626100.0 2737800.0 1442800.0 2445500.0 False True 3750038.6462630555 1379052.3252984306 1867923.2666534623 1.0 0.36774349690306996 0.4981077377735462 21.838474032795297 -9.82661584029883 6.525461259912027 1.000000012495883 0.4329256173397192 0.9618744126319431 0.053220978473269856 9.689610662226029e-09 1.7650973420523106e-09 0.05153099159170577 0.017176996941278683 1.490679090388383e-10 9.82661584029883 -0.5670743951561639 LFEMAYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFEMAYK 7 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 2475540.0 961310.0 981440.0 532790.0 False True 799371.8582537908 976152.7879194134 644193.9256573742 1.0 1.221149803861993 0.8058751618609652 19.60850725826304 -6.761995860985936 1.6046696543020063 1.1281319302098853 0.8041898729252802 0.6992144061115027 0.09304534066939427 0.2795548531789068 1.4191267182411917 0.04573782486077462 0.10971232081111 1.7298328451909904e-07 6.761995860985936 -0.3239420572846051 LFEMLVSEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFEMLVSEAR 10 0 E9PJK5;Q8N612-3;Q8N612;Q8N612-2 E9PJK5 FAM160A2 FTS and Hook-interacting protein 0 43120700.0 16395000.0 7048700.0 19677000.0 False True 15874549.699169276 9863282.668484895 14523003.402653283 1.0 0.621326768657951 0.9148608104085799 23.920212332884415 -9.811761025279887 6.009628492122937 1.0000000167663134 0.7680937895329212 0.45421880642404555 0.11983477073886771 2.6960822300063313e-08 5.178614031201134e-09 0.11602952648638308 0.03867650594717208 1.5425490219127033e-10 9.811761025279887 -0.23190622723339227 LFEMLVSEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFEMLVSEAR 10 0 E9PJK5;Q8N612-3;Q8N612;Q8N612-2 E9PJK5 FAM160A2 FTS and Hook-interacting protein 0 36350400.0 16395000.0 6064400.0 13891000.0 False True 13633168.921649534 6031729.87351084 16795543.875272766 1.0 0.4424305096031214 1.2319618404053783 23.70061760831869 -6.716986158431205 1.7702995632394949 0.6596876453246613 1.2305147459849677 0.49816661975261334 0.2347188265719063 0.36122063351030004 2.210750702068786 0.10534705737418777 0.2653886322813032 1.9187298922844352e-07 6.716986158431205 0.5708271006603064 LFETQESGDLNEELVK(ub)AAANGDVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFETQESGDLNEELVKAAANGDVAK 25 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 14757200.0 8579900.0 6177300.0 0.0 True False 11248331.98786979 5255670.918926802 0.0 1.0 0.46724002497388256 0.0 23.423207744654363 -8.03426465876973 0.5734390063728567 1.0162392273116987 3.3878297855435793e-15 0.9898530315100821 0.04115314516811873 0.11246423781674267 0.1662035921732071 0.0471527775108287 0.07573594447807436 9.241348351498324e-09 8.03426465876973 -1.0162392273116954 LFETQESGDLNEELVK(ub)AAANGDVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFETQESGDLNEELVKAAANGDVAK 25 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 278111000.0 56758000.0 89193000.0 132160000.0 True False 54956248.357758485 124808230.03535047 97543331.28498548 1.0 2.2710471286697755 1.7749270410525528 25.711780184735876 -10.389026339538924 5.416754362746212 0.9994983787881024 2.0229870848611777 0.8500521756426207 0.20254017763456098 0.0012275060003708127 0.0001384541887272543 0.19619706859177488 0.06536956124303861 4.082946229090564e-11 10.389026339538924 1.0234887060730753 LFETQESGDLNEELVK(ub)AAANGDVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFETQESGDLNEELVKAAANGDVAK 25 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 468088000.0 89398000.0 273010000.0 105680000.0 True False 135623301.8692449 224289232.463134 84792301.67881054 1.0 1.6537661992580917 0.6252045224541076 27.01502983287606 -6.734997638135065 1.7052792068782567 1.3912319964030957 0.6252663218219903 0.582168743561465 0.27473600213013727 0.3269409579018117 1.8647746873963917 0.1275660803461474 0.3147386584797776 1.840782012341411e-07 6.734997638135065 -0.7659656745811054 LFETQESGDLNEELVK(ub)AAANGDVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFETQESGDLNEELVKAAANGDVAK 25 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 37082000.0 8579900.0 2482100.0 26020000.0 True False 11752120.89307926 2372432.6147929262 19874611.89872136 1.0 0.20187272036914075 1.6911510764346693 23.486417806177254 -6.7611645535267 1.608443839389781 0.5370704369278105 1.696839207247002 0.6955751873784615 0.33574799317337234 0.28096240555776275 1.4329181335196546 0.16469001180541065 0.3952657665250723 1.7331471864645557e-07 6.7611645535267 1.1597687703191915 LFETQESGDLNEELVK(ub)AAANGDVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFETQESGDLNEELVKAAANGDVAK 25 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 203757000.0 56758000.0 78589000.0 68410000.0 True False 47196791.80573253 78165625.45830488 82714214.70789798 1.0 1.656163956652894 1.7525389235852995 25.492185460170152 -11.337587485066948 0.33557003207388164 3.659817606849018e-18 1.7711169823013175 0.9994299471035636 0.007983042870762399 3.5285697116047916 0.17264532254095957 2.631645088431595 0.030194855852591268 4.596343896206901e-12 11.337587485066948 1.7711169823013175 LFETQESGDLNEELVK(ub)AAANGDVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFETQESGDLNEELVKAAANGDVAK 25 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 379638000.0 89398000.0 226820000.0 63420000.0 True False 115727473.29803266 214197267.60919553 51878210.74415218 1.0 1.8508765594283207 0.44827912738188247 26.78615615496851 -6.742503634971441 1.677752872386267 1.5047961186377667 0.44703482312474957 0.6160547774120966 0.357486876438186 0.31329543647884295 1.732546680570777 0.16850737974144844 0.4123353794726469 1.8092407671508927e-07 6.742503634971441 -1.0577612955130171 LFFLQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFFLQVK 7 0 P26038;V9GZ54;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 232265000.0 69900000.0 106920000.0 55445000.0 False True 91639576.91256301 90967952.77089582 49708083.26599516 1.0 0.9926710252895644 0.542430300757757 26.449467462143122 -6.910436642576515 0.8927581753921865 1.0137485625716927 0.4836979405402709 0.9910852543688431 0.020204859180372493 0.1041299240950675 0.13720707973760476 0.0165777843007905 0.04590168818117184 1.2290324719583086e-07 6.910436642576515 -0.5300506220314218 LFFLQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFFLQVK 7 0 P26038;V9GZ54;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 306827000.0 177860000.0 73044000.0 55923000.0 False True 172213931.65564194 102210850.11942779 41275088.6459613 1.0 0.593510926420332 0.23967334262186607 27.35962661680172 -7.739079661619729 0.30495986385405954 1.1002549171276244 5.393348151963897e-13 0.9994243936000083 0.00745305096966348 0.12239914580082081 0.04506967487688916 0.03697243406675641 0.07960876897711693 1.8235611800836472e-08 7.739079661619729 -1.100254917127085 down LFFLQVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFFLQVK 7 0 P26038;V9GZ54;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 1376910000.0 391650000.0 562710000.0 422550000.0 False True 594161683.4502977 462290004.02670276 339032807.2897554 1.0 0.7780542180744205 0.5706069858308456 29.146280330144606 -6.97193943978011 0.20668079145687324 1.113317276127014 0.22957423193798165 0.9999938176743143 0.00043591288642103846 0.07567829840628165 0.006729287371473948 0.006378984293866497 0.021664745851179612 1.0667448631603181e-07 6.97193943978011 -0.8837430441890324 LFFLQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFFLQVK 7 0 P26038;V9GZ54;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 412750000.0 69900000.0 139690000.0 203160000.0 False True 95743918.9764731 133518033.90694335 155177792.21153843 1.0 1.3945327842675042 1.6207587267204915 26.512677523666014 -10.286107085821428 0.10535011968436533 6.910143354409253e-19 2.190086337878796 0.9999022539681629 0.0025360188406992183 2.05227008909716 0.05397871587479479 0.8602672349653875 0.32747872854218923 5.174792191853918e-11 10.286107085821428 2.190086337878796 LFFLQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFFLQVK 7 0 P26038;V9GZ54;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 313783000.0 177860000.0 70355000.0 65568000.0 False True 147898470.53397915 69975983.65062585 79277965.64782128 1.0 0.47313527582794795 0.5360296517035816 27.140031892235996 -10.252706166242557 5.527048732538924 1.000036697961315 0.5045824637666522 0.9880567085672155 0.025676521431090688 1.1611975309082875e-05 1.570000460353312e-06 0.02486302108605399 0.008287061657585616 5.588481708046411e-11 10.252706166242557 -0.4954542341946627 LFFLQVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFFLQVK 7 0 P26038;V9GZ54;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PQ82;E9PNV3;A0A2R8Y5P0;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 1347360000.0 391650000.0 538870000.0 416840000.0 False True 506998645.5756778 508881410.79519945 340979397.13958377 1.0 1.0037135507874657 0.6725449862936311 28.917406652237055 -6.904363903683772 0.9332572068510161 1.0121692171533934 0.6345295404891911 0.9886153865773838 0.01656459601364455 0.10826429738953136 0.15985368367970848 0.013194558954645977 0.03514656500312325 1.246338745426717e-07 6.904363903683772 -0.3776396766642023 LFFPVIYDVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFFPVIYDVK 10 0 Q9UIV1-2;Q9UIV1;H0YBT3;H0YAV9 Q9UIV1-2 CNOT7 CCR4-NOT transcription complex subunit 7 0 1341740.0 291450.0 457050.0 593240.0 False True 382093.77240581455 388859.92156694626 531857.2155599055 1.0 1.0177080854224065 1.3919546822527902 18.543567218412097 -6.9167694461219495 0.8483461577158765 0.9907425103959249 1.4480371051494276 0.9932353637485859 0.014865396461583809 0.10011002924076605 0.11574105611356564 0.012593596420919688 0.03663328691203143 1.211240974305412e-07 6.9167694461219495 0.45729459475350276 LFFPVIYDVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFFPVIYDVK 10 0 Q9UIV1-2;Q9UIV1;H0YBT3;H0YAV9 Q9UIV1-2 CNOT7 CCR4-NOT transcription complex subunit 7 0 1939500.0 291450.0 731380.0 916670.0 False True 399206.94114010053 699065.2132497691 700171.425411256 1.0 1.7511349157740073 1.7539059401412884 18.606777279934988 LFFQPHQAGLSK(ub)VQAAEHTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFFQPHQAGLSKVQAAEHTLR 21 1 E7EQ61;Q9GZZ9;E7EWE1;Q9GZZ9-2;C9JRV9;C9J5W5 E7EQ61 UBA5 Ubiquitin-like modifier-activating enzyme 5 1 11450800.0 3316200.0 3648500.0 4486100.0 True False 3210929.046196103 5105365.076676144 3311055.8298847824 1.0 1.5899962295100623 1.031183119355221 21.614559354651945 -10.344436878034275 4.108779760972553 0.9993710410141381 1.3105896744415164 0.29172873682413736 0.22813449693910307 0.0013170154259591082 0.00021013252557938476 0.22132960731415594 0.0736300923673222 4.5244221717852594e-11 10.344436878034275 0.3112186334273783 LFFQPHQAGLSK(ub)VQAAEHTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFFQPHQAGLSKVQAAEHTLR 21 1 E7EQ61;Q9GZZ9;E7EWE1;Q9GZZ9-2;C9JRV9;C9J5W5 E7EQ61 UBA5 Ubiquitin-like modifier-activating enzyme 5 1 8115800.0 3316200.0 3010300.0 1789300.0 True False 2757567.232569329 2994082.9164022333 2163434.357211548 1.0 1.0857696889633164 0.7845445549466422 21.39496463008622 -6.8306079031097955 1.3251025099212765 1.0458117825072066 0.7763327283047977 0.9070981778666919 0.03862299276043932 0.18006476755042844 0.6181280196103063 0.022883164896080815 0.052662269385104855 1.4770394565454428e-07 6.8306079031097955 -0.2694790542024089 LFFWMQEPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFFWMQEPK 9 0 Q16186 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 0 14796100.0 4605500.0 5620600.0 4570000.0 False True 6037855.0997254355 4782028.388927207 4097140.238535451 1.0 0.792007809055349 0.6785754495369992 22.525604703880923 -13.999999999999085 0.07364656225804081 2.1702117709529793 0.2960981453303625 0.999911517800171 0.0012519950856899424 12.322654673798027 0.07445678845718255 2.425510248612656 0.3503449444266043 1.0000000000021064e-14 13.999999999999085 -1.8741136256226167 LFFWMQEPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFFWMQEPK 9 0 Q16186 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 0 10015900.0 5062200.0 1478800.0 3474900.0 False True 4901503.2319081845 2069292.5518401251 2564719.4452345367 1.0 0.4221750866895863 0.5232516074943148 22.224792843578015 -10.278513889488833 7.263677688446645 1.000003029731263 0.4727133470922995 0.9731798385802158 0.041264316824565474 2.024572414405108e-06 2.0110130752198392e-07 0.03995423237231797 0.013318000987847379 5.2660637284178095e-11 10.278513889488833 -0.5272896826389635 LFFWMQEPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFFWMQEPK 9 0 Q16186 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 0 19764800.0 4605500.0 6061600.0 9097700.0 False True 6308277.808957736 5793778.468969338 6949010.633012961 1.0 0.9184406020835336 1.1015701659723016 22.588814765403814 -6.785649866561225 1.5138368390478318 0.9541572680807834 1.1032867148793601 0.7868701422860177 0.03458338678094685 0.24189818642536742 1.0952033687090457 0.017987034609144328 0.04224632465240412 1.6381366746994475e-07 6.785649866561225 0.14912944679857676 LFFWMQEPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFFWMQEPK 9 0 Q16186 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 0 10310500.0 5062200.0 2662200.0 2586100.0 False True 4209443.593484248 2647858.2001946745 3126841.553224599 1.0 0.629028074943982 0.7428158814301736 22.00519811901229 -10.59055362057537 9.464828019805555 1.0000418502428348 0.6859219781870782 0.9103808649344034 0.04645367747362057 4.102894763180358e-05 1.7748687158444665e-06 0.044984535796177096 0.01499285993545192 2.567121236508726e-11 10.59055362057537 -0.31411987205575653 LFFWMQEPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFFWMQEPK 9 0 Q16186 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 0 8866800.0 1564800.0 4661900.0 2640100.0 False True 2025664.4468194053 4402461.166860547 2159628.889713595 1.0 2.1733417762122773 1.0661335805663836 20.949963779493203 -6.632467333641689 2.071076330285471 1.771595381252472 1.0705860370074887 0.1266200439305536 0.5029815839662778 0.5525841946817388 4.5199286461568775 0.19839247912966068 0.5572641859215878 2.3309484357999472e-07 6.632467333641689 -0.7010093442449834 LFFWMQEPK(ub)TDQDEEHCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFFWMQEPKTDQDEEHCR 18 1 Q16186 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 15744400.0 5724500.0 7356400.0 2663500.0 True False 7504874.936136861 6258853.795022615 2387906.570096099 1.0 0.8339717647905754 0.31818072791567065 22.839396599795254 -6.950662632004355 0.5515195108884474 1.007069822188386 0.1207882581167995 0.9992522730012229 0.007938220714975104 0.08322072131599201 0.03486937548063526 0.008599232159941564 0.042801657880071654 1.1203078213925584e-07 6.950662632004355 -0.8862815640715865 down LFFWMQEPK(ub)TDQDEEHCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFFWMQEPKTDQDEEHCR 18 1 Q16186 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 41212000.0 12732000.0 16232000.0 12248000.0 True False 19315374.833880242 13335272.77880513 9827177.431510897 1.0 0.6903967897850121 0.5087748757675404 24.203246338971805 -10.291497650113058 0.09770614937701415 1.8523284538419644 3.1153703021149245e-10 0.9999266339990267 0.0017370343923237216 2.0476598825068764 0.04973918263424056 0.7046994865471314 0.2866386917175185 5.110958444747882e-11 10.291497650113058 -1.8523284535304274 LFFWMQEPK(ub)TDQDEEHCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFFWMQEPKTDQDEEHCR 18 1 Q16186 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 17704000.0 5724500.0 8900200.0 3079300.0 True False 7841002.348795706 8506959.734974425 2352032.760174198 1.0 1.0849326854596597 0.2999658277790779 22.902606661318146 -6.880108634312196 1.0792432018901406 1.052709127325989 0.24423078776896398 0.9737708002271667 0.056964406292772274 0.12753158671297132 0.27173233205620434 0.040656468367567075 0.09834082229476779 1.3179270313863748e-07 6.880108634312196 -0.808478339557025 down LFFWMQEPK(ub)TDQDEEHCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFFWMQEPKTDQDEEHCR 18 1 Q16186 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 48559000.0 12732000.0 21188000.0 14639000.0 True False 16481824.985240739 20008869.174251117 11974852.208824422 1.0 1.2139959738784267 0.7265489240146493 23.974372661064255 -6.78735957289715 1.5067095167581517 1.1200143641436788 0.7217239105268822 0.7927014864374944 0.0908289107663607 0.23931205163215388 1.0732748513110208 0.047455659713402015 0.1113302302041222 1.6317004266896427e-07 6.78735957289715 -0.3982904536167966 LFGFVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFGFVLR 7 0 Q9UKG1 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 0 2025070.0 906750.0 792650.0 325670.0 False True 1241999.9789973816 757628.1020569722 248753.45338418797 1.0 0.6100065337107139 0.20028458743211652 20.244233718486132 -7.586757018617156 0.3709602362478384 1.0526045674576834 6.668812816463764e-20 0.9990305660291965 0.01016630029509257 0.12238541761527774 0.04886989280408321 0.02372322286838616 0.07087994196901001 2.5896613874199947e-08 7.586757018617156 -1.0526045674576834 down LFGFVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFGFVLR 7 0 Q9UKG1 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 0 10536800.0 1267400.0 3994600.0 5274800.0 False True 1640674.2841889814 3772296.9984643934 4314840.524018516 1.0 2.299235768377461 2.629919031217966 20.64585742473482 -10.238293849438868 0.31001571380657805 4.8241431818033997e-23 2.729981705070029 0.9989743402761094 0.022529706779055955 1.6945761843510487 0.14430843674332297 1.5304984976459568 0.11335692623296197 5.777050322076408e-11 10.238293849438868 2.729981705070029 LFGHSSTSALSAILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFGHSSTSALSAILR 15 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 10406100.0 2567100.0 4645900.0 3193100.0 False True 3365492.9598317617 3952749.8295763596 2862708.642378017 1.0 1.1744935665454355 0.8506060409412122 21.6823864080725 -6.760409843092951 1.6112728516491692 1.1013059008474928 0.8494129872101351 0.6925048687422857 0.07339592897434107 0.28223018521428567 1.4442827957773707 0.03594144226197995 0.08632610972412803 1.7361616421173552e-07 6.760409843092951 -0.25189291363735766 LFGHSSTSALSAILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFGHSSTSALSAILR 15 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 12724900.0 5895000.0 2432400.0 4397500.0 False True 5707866.451759862 3403670.0047984277 3245662.8278278136 1.0 0.596312130559572 0.5686297770381618 22.444520149471117 -13.999999999999998 0.380635482491209 7.013567721262765 0.5662247180809296 0.9998085413215206 0.0027279204915119336 24.115269022336854 0.20126224369980147 118.86357208417225 0.007488805312377625 1.0000000000000041e-14 13.999999999999998 -6.447343003181835 LFGHSSTSALSAILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFGHSSTSALSAILR 15 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 11898900.0 3000100.0 3249500.0 5649300.0 False True 4551371.036688976 2669601.3365406157 4532713.378823845 1.0 0.5865488256221565 0.9959006510972781 22.117869771752343 -10.929730428288934 10.466511106668431 1.0383885566693036 0.7912247383597173 0.25750993681238665 0.16711718294848 0.09561861123754894 0.0006419588256521643 0.10335284330417671 0.053936838868713415 1.175627054100606e-11 10.929730428288934 -0.24716381830958634 LFGHSSTSALSAILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFGHSSTSALSAILR 15 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 13753400.0 2567100.0 4702800.0 6483500.0 False True 3516226.243269008 4495014.745920056 4952230.831873934 1.0 1.2783633460801076 1.4083936838119617 21.74559646959539 -12.645049611544088 0.1149664662319244 1.680500263042561e-17 1.6475569884084376 0.9997583173922018 0.0026483166299949364 7.366589447364238 0.09022081045783732 1.905360519749495 0.19238264368797584 2.264385621175079e-13 12.645049611544088 1.6475569884084376 LFGHSSTSALSAILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFGHSSTSALSAILR 15 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 10129500.0 5895000.0 1869100.0 2365400.0 False True 4901953.692779752 1859030.7873126992 2859994.203626104 1.0 0.3792428292521258 0.5834396615860903 22.224925424905393 -10.200845326590528 4.891348486982396 1.00006396417175 0.4813412454180722 0.8958560443264614 0.08336300772211419 5.815606031389035e-05 9.501525904199184e-06 0.08072579683720957 0.02690529504927384 6.297304205862542e-11 10.200845326590528 -0.5187227187536777 LFGHSSTSALSAILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFGHSSTSALSAILR 15 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 15252600.0 3000100.0 7186700.0 5065800.0 False True 3883688.5908121807 6786753.827382979 4143876.3794974233 1.0 1.747502063743914 1.066995018421606 21.888996093844792 -10.324458467665862 5.720264550641204 0.9999443390705937 1.4072485410827167 0.3231907108736435 0.27781583790145525 0.00019724997815998425 2.3294196638186244e-05 0.26903065138457743 0.08966467612541511 4.737416107398661e-11 10.324458467665862 0.40730420201212303 LFGLLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFGLLVK 7 0 I3L0N3;P46459;P46459-2;I3L0L3 I3L0N3 NSF Vesicle-fusing ATPase 0 9613500.0 3243600.0 3262700.0 3107200.0 False True 4252391.011067081 2775917.8779049874 2785696.750367032 1.0 0.6527898941279173 0.6550895115517607 22.019842829361448 -10.068923912944344 7.1918888124625955 1.0000000696556073 0.6539397028398416 0.9999668814790728 0.0009388148820051315 1.0479493233245972e-09 1.3748831211171401e-10 0.0009090037768808061 0.0003030012002647641 8.532495876233976e-11 10.068923912944344 -0.3460603668157657 LFGLLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFGLLVK 7 0 I3L0N3;P46459;P46459-2;I3L0L3 I3L0N3 NSF Vesicle-fusing ATPase 0 9579200.0 3243600.0 3411200.0 2924400.0 False True 4442846.574994101 3260481.9046700876 2233716.949908557 1.0 0.7338722707692008 0.5027670688609189 22.08305289088434 -6.972776033598881 0.17991599142407522 1.1788555905458693 0.051534759893415716 0.9999967221037405 0.00036777919020601353 0.0754117486709939 0.005673411518507973 0.008906176713758405 0.025941696669040434 1.064691940111994e-07 6.972776033598881 -1.1273208306524536 LFGYEPTIYYPKRPNK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFGYEPTIYYPKRPNK 16 2 Q8NCW5-2;Q8NCW5;Q5T3I4;Q5T3I3 Q8NCW5-2 APOA1BP NAD(P)H-hydrate epimerase 1 5192300.0 2364900.0 1177700.0 1649700.0 True False 2289827.543980811 1647961.7516243677 1217594.0800608401 1.0 0.7196881511694219 0.5317405161194287 21.126807516636553 -8.213353237642606 0.1134154380341699 1.4828392939906578 1.221959623772393e-09 0.9999768802824517 0.0009251068167003489 0.08482195977065027 0.02252854241798149 0.135648556362338 0.14059017765868018 6.118525330719404e-09 8.213353237642606 -1.4828392927686982 LFGYEPTIYYPKRPNK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFGYEPTIYYPKRPNK 16 2 Q8NCW5-2;Q8NCW5;Q5T3I4;Q5T3I3 Q8NCW5-2 APOA1BP NAD(P)H-hydrate epimerase 1 85278000.0 34116000.0 29484000.0 21678000.0 True False 51756466.21368661 24222349.84045658 17393333.798195057 1.0 0.46800625337228224 0.3360610774001321 25.625235781734567 -13.999999999999954 0.19580829025759952 3.9113742886332394 0.24674178878237074 0.9994872491809821 0.006498478661495642 12.451138654338733 0.14032361203689064 13.859846811961132 0.0867196335537255 1.0000000000001063e-14 13.999999999999954 -3.664632499850869 LFGYEPTIYYPKRPNK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFGYEPTIYYPKRPNK 16 2 Q8NCW5-2;Q8NCW5;Q5T3I4;Q5T3I3 Q8NCW5-2 APOA1BP NAD(P)H-hydrate epimerase 1 59770300.0 34116000.0 15812000.0 9842300.0 True False 44163834.52689857 14932048.300134923 8051102.390526162 1.0 0.3381057931244707 0.1823008005707143 25.396362103827016 -13.999999999999863 0.20320765461137516 4.7251424162971984 0.08425291006065219 0.9994873482361613 0.008026446179735197 12.596169041810702 0.14292190559963988 18.67553330825844 0.09688718291129807 1.0000000000003149e-14 13.999999999999863 -4.6408895062365465 LFHFLGIFLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFHFLGIFLAK 11 0 Q9ULT8;A0A087X2H1;H0YJD4 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 0 16206000.0 4950400.0 7362500.0 3893100.0 False True 7510118.722717611 6048604.351524949 3123627.0785936527 1.0 0.80539397243193 0.4159224632687747 22.840404283897556 -6.960031808151276 0.4349855233300745 1.0146767527629268 0.191580486009903 0.9997713761642752 0.0036716900658329233 0.07968976693261152 0.021089365985812132 0.0051048101021440445 0.03230252413007515 1.0963978919518864e-07 6.960031808151276 -0.8230962667530238 down LFHFLGIFLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFHFLGIFLAK 11 0 Q9ULT8;A0A087X2H1;H0YJD4 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 0 14008700.0 4950400.0 4398100.0 4660200.0 False True 6408390.386972639 4153341.8687593853 3812091.4176899726 1.0 0.6481099961080006 0.5948594245193647 22.611530605990005 -13.999999999999998 0.2658670527756806 3.656748435700475 0.5764633487367076 0.9995745205025393 0.003707793582557448 14.684477554927495 0.1631937184328254 21.034242052918547 0.022582492618106794 1.0000000000000041e-14 13.999999999999998 -3.0802850869637677 LFHIDFGYILGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFHIDFGYILGR 12 0 A8MYT4;A0A1W2PS05;Q8NEB9 A8MYT4 PIK3C3 Phosphatidylinositol 3-kinase;Phosphatidylinositol 3-kinase catalytic subunit type 3 0 43199000.0 12496000.0 16067000.0 14636000.0 False True 18957345.579969168 13199718.317956042 11743188.184813302 1.0 0.6962851556550835 0.6194531895447148 24.176253635477863 -13.999999999999998 0.19300514936950505 2.6453546397324033 0.5659693121990291 0.9994880343120923 0.0037176421849762697 12.401202253459683 0.13931923651333064 7.68168101130195 0.051602704307485106 1.0000000000000041e-14 13.999999999999998 -2.079385327533374 LFHIDFGYILGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFHIDFGYILGR 12 0 A8MYT4;A0A1W2PS05;Q8NEB9 A8MYT4 PIK3C3 Phosphatidylinositol 3-kinase;Phosphatidylinositol 3-kinase catalytic subunit type 3 0 28461100.0 12496000.0 7552800.0 8412300.0 False True 16176318.33298525 7132480.040555214 6881347.717487092 1.0 0.44092109797390183 0.42539640824545877 23.947379957570313 LFIFHSSLPTAEAPGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFIFHSSLPTAEAPGK 16 0 O94855;O94855-2;E9PDM8;E9PC44 O94855 SEC24D Protein transport protein Sec24D 0 18874800.0 7005300.0 6500200.0 5369300.0 False True 9184016.139421703 5530395.497581154 4813736.341962439 1.0 0.6021761518735083 0.5241428443597606 23.130693746643 -13.999999999999998 0.2290101645321625 3.4998948780623 0.48584328493694945 0.9995084577086013 0.004619896684228476 13.260604065376947 0.1515305034630822 15.06525350307668 0.040757054055817483 1.0000000000000041e-14 13.999999999999998 -3.0140515931253504 LFIFHSSLPTAEAPGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFIFHSSLPTAEAPGK 16 0 O94855;O94855-2;E9PDM8;E9PC44 O94855 SEC24D Protein transport protein Sec24D 0 11436300.0 4616800.0 2493500.0 4326000.0 False True 4470242.211108552 3489167.5534307174 3192890.822781833 1.0 0.7805321028825095 0.7142545463973963 22.09192157238785 -13.999999999995309 0.1677636401916203 2.100453406456341 0.654376207632796 0.9995181229805429 0.0026806320824912704 12.070563361015646 0.1296570225013344 4.321977497314323 0.05515574336666964 1.0000000000108022e-14 13.999999999995309 -1.446077198823545 LFIFHSSLPTAEAPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFIFHSSLPTAEAPGK 16 0 O94855;O94855-2;E9PDM8;E9PC44 O94855 SEC24D Protein transport protein Sec24D 0 19931900.0 7005300.0 5289900.0 7636700.0 False True 9595348.721114254 5056174.726639978 5833068.742773449 1.0 0.5269401742027394 0.6079058627580642 23.193903808165892 -10.777494375815442 7.092250795493541 1.0114287232355317 0.5674230184804019 0.974398058430874 0.03305410393894091 0.00592468630549296 0.00018587530267028424 0.031744414908711674 0.010668166173277267 1.669189423347076e-11 10.777494375815442 -0.4440057047551298 LFIFHSSLPTAEAPGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFIFHSSLPTAEAPGK 16 0 O94855;O94855-2;E9PDM8;E9PC44 O94855 SEC24D Protein transport protein Sec24D 0 9120600.0 4616800.0 1954500.0 2549300.0 False True 3839073.758918669 1943970.7205621249 3082346.8433685736 1.0 0.5063645146296102 0.802888154000136 21.872326847822126 -10.33663015591825 5.873532040213826 1.0000438495545954 0.654626334314874 0.6439802894697059 0.12105526885514287 6.951926513000334e-05 7.851539115353429e-06 0.11722610054473541 0.039070420020552096 4.606486938552971e-11 10.33663015591825 -0.3454175152397213 LFIFHSSLPTAEAPGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFIFHSSLPTAEAPGK 16 0 O94855;O94855-2;E9PDM8;E9PC44 O94855 SEC24D Protein transport protein Sec24D 0 12974300.0 2468900.0 8133200.0 2372200.0 False True 3196039.7192947543 7680580.270342598 1940483.9408274663 1.0 2.4031554501573633 0.6071526361554912 21.607853907024825 -6.698192536650504 1.836856193913902 1.8727775757300467 0.6125605403599058 0.4093514168515281 0.5924770378854978 0.3992133592086096 2.617300149384865 0.25742311016351416 0.6636183490642651 2.0035835776832664e-07 6.698192536650504 -1.260217035370141 LFIGGLNTETNEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFIGGLNTETNEK 13 0 P38159;P38159-2;H3BT71;H0Y6E7;Q96E39;H3BR27;P38159-3;H3BNC1;A0A1B0GUK8 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 39542000.0 8858000.0 11504000.0 19180000.0 False True 11612923.78099401 9787648.042240776 17195437.587551408 1.0 0.8428237562584778 1.4807156157946955 23.469227908878274 -6.841523624693118 1.275293052869445 0.9163960515874822 1.5023383378819481 0.9270451797184905 0.07329317526838879 0.16702502110230283 0.5270117528696633 0.045053510230425746 0.10384122268285041 1.440377654644272e-07 6.841523624693118 0.585942286294466 LFIGGLNTETNEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFIGGLNTETNEK 13 0 P38159;P38159-2;H3BT71;H0Y6E7;Q96E39;H3BR27;P38159-3;H3BNC1;A0A1B0GUK8 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 25118900.0 8856600.0 3579300.0 12683000.0 False True 8575452.080857744 5008533.155802916 9360941.818155803 1.0 0.5840547073877354 1.0915974726337099 23.031781298641054 -6.688824545978358 1.8699986659271772 0.738959711093836 1.0898504358033254 0.36528246825200206 0.17595490265810407 0.419151951405921 2.8407165993279895 0.07528958270267437 0.1963932747381114 2.0472715629128342e-07 6.688824545978358 0.35089072470948945 LFIGGLNTETNEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFIGGLNTETNEK 13 0 P38159;P38159-2;H3BT71;H0Y6E7;Q96E39;H3BR27;P38159-3;H3BNC1;A0A1B0GUK8 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 38649900.0 8858000.0 9138900.0 20653000.0 False True 12133041.978449164 8735113.179699082 15775186.761886684 1.0 0.7199441982657343 1.3001839761130585 23.532437970401165 -6.7754598263993655 1.5535381858238462 0.840490751762893 1.3041445562345884 0.7510091862928219 0.11822535291867992 0.257690714064626 1.2280629111175831 0.05995893671542171 0.1420255193487084 1.677027458869465e-07 6.7754598263993655 0.46365380447169535 LFIGGLNTETNEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFIGGLNTETNEK 13 0 P38159;P38159-2;H3BT71;H0Y6E7;Q96E39;H3BR27;P38159-3;H3BNC1;A0A1B0GUK8 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 18919500.0 8856600.0 5940200.0 4122700.0 False True 7364655.313905542 5908198.963562616 4984737.50878893 1.0 0.8022369970807834 0.6768460024703423 22.81218657407533 -10.27797123647844 0.0603179163844874 1.9044711811843746 6.032151107283118e-11 0.9999874709366166 0.0004708265600984684 2.0685247424950655 0.031047446657352127 0.635083782926462 0.36458488862817195 5.272647812533097e-11 10.27797123647844 -1.9044711811240531 LFIGGLNTETNEK(ub)ALEAVFGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFIGGLNTETNEKALEAVFGK 21 1 P38159;P38159-2;H3BT71;H0Y6E7;H3BR27;P38159-3;H3BNC1 P38159 RBMX RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed 1 14765600.0 6941600.0 6725500.0 1098500.0 True False 9100504.822550021 5722081.615793668 984837.7575560595 1.0 0.6287652968014474 0.10821792601172443 23.117515145930984 -7.53030474205553 0.5132791249074642 1.012628014648646 2.8632013264116573e-22 0.9964906123711252 0.021667982271250427 0.11664696583980586 0.07710211659757507 0.023867240213627836 0.0703339620262167 2.9491391057227602e-08 7.53030474205553 -1.012628014648646 down LFIGGLNTETNEK(ub)ALEAVFGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFIGGLNTETNEKALEAVFGK 21 1 P38159;P38159-2;H3BT71;H0Y6E7;H3BR27;P38159-3;H3BNC1 P38159 RBMX RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed 1 111936000.0 67022000.0 27096000.0 17818000.0 True False 64894423.29598804 37915574.10377327 13150931.27145787 1.0 0.5842655220285674 0.2026511771508554 25.951591169725518 -7.735381320800574 0.34315916740629115 1.074421164060256 3.348323722038087e-21 0.9990534744414928 0.010017776443483613 0.12019726134110247 0.05300859449367422 0.0333723844651516 0.07821070107084611 1.8391564695672703e-08 7.735381320800574 -1.074421164060256 down LFIGGLNTETNEK(ub)ALEAVFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFIGGLNTETNEKALEAVFGK 21 1 P38159;P38159-2;H3BT71;H0Y6E7;H3BR27;P38159-3;H3BNC1 P38159 RBMX RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed 1 203614000.0 59642000.0 63453000.0 80519000.0 True False 90481274.41425419 52129316.38944811 64604384.3572686 1.0 0.5761337550439695 0.7140083379184919 26.431115913810892 -10.92492892320716 11.322131691129174 1.050139131965017 0.6450710464812307 0.8983321211751301 0.05628706275694201 0.030040914202060648 0.00019918511252327428 0.0229822079782157 0.018166571388714012 1.1886967540614758e-11 10.92492892320716 -0.40506808548378637 LFIGGLNTETNEK(ub)ALEAVFGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFIGGLNTETNEKALEAVFGK 21 1 P38159;P38159-2;H3BT71;H0Y6E7;H3BR27;P38159-3;H3BNC1 P38159 RBMX RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed 1 10974100.0 6941600.0 2976300.0 1056200.0 True False 9508097.109686475 2844797.2246920676 806747.3131218102 1.0 0.299197325382163 0.08484845114801444 23.180725207453875 -10.3066775989803 0.2737138202679697 1.6454959488643348 9.687187678887528e-26 0.9989987116832268 0.012366364644589952 1.873499094571532 0.13324818327445986 0.9538005737657507 0.08544713498432334 4.935400503055246e-11 10.3066775989803 -1.6454959488643348 LFIGGLNTETNEK(ub)ALEAVFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFIGGLNTETNEKALEAVFGK 21 1 P38159;P38159-2;H3BT71;H0Y6E7;H3BR27;P38159-3;H3BNC1 P38159 RBMX RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed 1 115759000.0 67022000.0 37981000.0 10756000.0 True False 55731762.578029625 37776388.81436176 13005029.869875045 1.0 0.6778251228188112 0.2333504139881957 25.731996445159794 -7.2772271631958665 0.3976190891664321 1.031910561873528 3.0727162650361254e-11 0.9995458800523049 0.0066979306346589655 0.09908597681716552 0.030389793363107265 0.011166194878686475 0.050233775601374944 5.281689141111647e-08 7.2772271631958665 -1.0319105618428008 down LFIGGLNTETNEK(ub)ALEAVFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFIGGLNTETNEKALEAVFGK 21 1 P38159;P38159-2;H3BT71;H0Y6E7;H3BR27;P38159-3;H3BNC1 P38159 RBMX RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed 1 182022000.0 59642000.0 81762000.0 40618000.0 True False 77207744.71958272 77211872.8254257 33225940.775874745 1.0 1.0000534675097423 0.43034466162106955 26.20224223590334 -6.906871740432417 0.9167754966854254 1.0194315066539046 0.36144115061165616 0.9896865066102154 0.027272765898727788 0.10652316326629552 0.15025775689705778 0.0219888095171103 0.05946062530802493 1.2391624925813412e-07 6.906871740432417 -0.6579903560422484 down LFIGGLNVQTSESGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFIGGLNVQTSESGLR 16 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 13701200.0 3232500.0 5189900.0 5278800.0 False True 4237838.8035745295 4415587.150071751 4732600.413825148 1.0 1.0419431589392438 1.1167485676504016 22.014897281690576 -6.962222102112948 0.40289600432543515 0.9960169256507303 1.1654190558608173 0.9998439261494043 0.0006032281242866017 0.0789167352527084 0.018267116413049348 0.000962334986198797 0.006260837108936063 1.0908823067248984e-07 6.962222102112948 0.169402130210087 LFIGGLNVQTSESGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFIGGLNVQTSESGLR 16 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 38901000.0 13124000.0 12054000.0 13723000.0 False True 12707385.803714406 16867225.060779594 10128534.618824579 1.0 1.327356021239967 0.7970588738923767 23.599163930122412 -6.739728471331772 1.6879022700920912 1.1948381693674126 0.7967789171520593 0.6036456730002662 0.1375414316074078 0.31830098761630504 1.7805299155832193 0.06446971234155104 0.15823710687388978 1.820838923825805e-07 6.739728471331772 -0.3980592522153533 LFIGGLNVQTSESGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFIGGLNVQTSESGLR 16 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 55369000.0 16607000.0 25943000.0 12819000.0 False True 25194033.134326804 21313268.956415817 10285319.031232696 1.0 0.8459649490329734 0.4082442448334711 24.58657875560246 -6.9526626641903695 0.5288046227124844 1.0069632943636382 0.22741569239131154 0.9993940142611192 0.0061705869824094295 0.0824338432874253 0.03167132106053957 0.006896410303162954 0.036191651203990115 1.1151603918697432e-07 6.9526626641903695 -0.7795476019723266 down LFIGGLNVQTSESGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFIGGLNVQTSESGLR 16 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 16847700.0 3232500.0 4757600.0 8857600.0 False True 4427642.605027881 4547393.500720684 6765617.307998234 1.0 1.0270461973504406 1.5280405198729066 22.078107343213468 -6.91805281597 0.8390274479689521 0.9881515524381425 1.6053233510728775 0.9936231221415021 0.019388642717064617 0.09933089996873032 0.1116457677157721 0.016535367333884027 0.048646728287708475 1.2076669578538376e-07 6.91805281597 0.617171798634735 LFIGGLNVQTSESGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFIGGLNVQTSESGLR 16 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 25246800.0 13124000.0 6493800.0 5629000.0 False True 10913187.491779724 6458816.610481623 6805997.874444632 1.0 0.591835943013595 0.6236489457888631 23.379569205556688 -10.062601024943774 5.280269338279213 1.0000044040487919 0.6077424444006408 0.9950910246665297 0.012987603999583163 6.733466381024339e-07 1.1956098469576897e-07 0.012575334750630371 0.004191731166163386 8.657629074399643e-11 10.062601024943774 -0.392261959648151 LFIGGLNVQTSESGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFIGGLNVQTSESGLR 16 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 52985000.0 16607000.0 23085000.0 13293000.0 False True 21498088.8729102 21800299.456654068 10873810.397698132 1.0 1.0140575557916072 0.5058035838432248 24.35770507769491 -6.900538106280183 0.9578452262951794 1.0208204773149483 0.45186414912599315 0.9868325389348505 0.027121001061320833 0.11101076871989672 0.17518814001973113 0.021214135356688157 0.055346956912184234 1.2573665244759129e-07 6.900538106280183 -0.5689563281889551 LFIGGLPNYLNDDQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFIGGLPNYLNDDQVK 16 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 17474800.0 1346000.0 11995000.0 4133800.0 False True 1764619.0346825412 10205392.7561438 3706074.030209592 1.0 5.783340514616954 2.1002119762786777 20.750925321603276 -6.580083938172728 2.2660629091349622 4.257177145519965 2.1092436146426286 0.0 2.077986623625499 0.6992552299743257 6.75359673529563 0.7698467722711211 2.323376746781345 2.6297596765379336e-07 6.580083938172728 -2.147933530877337 LFIGGLPNYLNDDQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFIGGLPNYLNDDQVK 16 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 26249900.0 9780900.0 6850100.0 9618900.0 False True 9470410.683293972 9585380.652799586 7099421.5291854255 1.0 1.0121399138168763 0.7496424143156719 23.17499555868254 -6.896059357592941 0.9858687058496596 1.0121247370145114 0.7241938024575194 0.9845009400167151 0.015061761829733424 0.11436349439404955 0.19424038755015036 0.011538154046952036 0.029467922620396225 1.270400460205004e-07 6.896059357592941 -0.28793093455699204 LFIGGLPNYLNDDQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFIGGLPNYLNDDQVK 16 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 25370800.0 1346000.0 6956800.0 17068000.0 False True 1843652.5742822974 6649425.572938812 13036889.92649407 1.0 3.6066586870507966 7.071229204650507 20.814135383126168 -6.967189033723402 0.31825013391026835 0.5156789099990238 10.273670053828663 0.9999514195676432 0.01733293875076064 0.07722577388040763 0.01228066316824298 0.05289358710233702 0.3052275169201569 1.0784771953458236e-07 6.967189033723402 9.75799114382964 LFIGGLPNYLNDDQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFIGGLPNYLNDDQVK 16 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 15173900.0 9780900.0 2770400.0 2622600.0 False True 8133251.717338325 2755475.305318656 3170973.5344676664 1.0 0.33879134706289504 0.3898777075481188 22.955400834116816 -10.230967695669602 8.434631524029824 1.0000002073597714 0.3643345273055069 0.9951792424777118 0.020855919334113238 8.135248787228941e-08 7.384814792718887e-09 0.020193663682383598 0.006731219020905494 5.875330536514798e-11 10.230967695669602 -0.6356656800542644 LFIGGLSFETTDDSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFIGGLSFETTDDSLR 16 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 23321600.0 9194900.0 5322300.0 8804400.0 False True 8903012.932533784 7447522.145427847 6498263.513661666 1.0 0.8365170534811628 0.7298948752411022 23.085862220822964 -9.45629774463822 0.05171008148906615 1.8320444734642796 5.894378079848734e-08 0.9999959711102167 0.00022288891762704284 0.9325807890519585 0.020147860286322167 0.405204908199792 0.30594873377808324 3.497053330153347e-10 9.45629774463822 -1.8320444145204988 LFIGGLSFETTDDSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFIGGLSFETTDDSLR 16 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 93590000.0 22169000.0 40331000.0 31090000.0 False True 33631993.770993665 33133617.94245874 24945047.872768927 1.0 0.9851814961691402 0.7417058900112873 25.00333097142168 -6.919353154992472 0.8295219249867947 1.0054984235840456 0.7030230451453684 0.9939990945438045 0.00917368713774685 0.09855379389897881 0.10760137278454988 0.007877110557301732 0.0234513281558062 1.2040564402973888e-07 6.919353154992472 -0.3024753784386772 LFIGGLSFETTDDSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFIGGLSFETTDDSLR 16 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 19477300.0 9194900.0 3057900.0 7224500.0 False True 7645966.753136637 3041426.485754375 8735109.547686145 1.0 0.3977818088872382 1.142446708142264 22.86626749625724 -6.691555753762231 1.8610356885080235 0.6229915879956496 1.1399103386570424 0.3776219172717905 0.2546171989407957 0.41334911844007965 2.7768851558050134 0.10940453861126735 0.2843240858713486 2.034437002575571e-07 6.691555753762231 0.5169187506613928 LFIGGLSFETTDDSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFIGGLSFETTDDSLR 16 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 69519700.0 22169000.0 26509700.0 20841000.0 False True 28698207.51632125 25034411.891100846 17048151.846718334 1.0 0.872333642331608 0.5940493613415648 24.77445729351413 -6.958326972632256 0.4584030582428089 1.0082421404873674 0.44695266275700407 0.9997030295590537 0.0029207585770812455 0.0803042476585408 0.02338101098423542 0.0037692668089592462 0.022993206776040453 1.1007102921981637e-07 6.958326972632256 -0.5612894777303633 LFIGGLSFETTDESLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFIGGLSFETTDESLR 16 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;F8W646;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 31102700.0 8477800.0 14511000.0 8113900.0 False True 11114477.89913199 12346015.363434989 7274351.462024673 1.0 1.110804796723666 0.6544933129600968 23.405936843793324 -6.842551961524827 1.2705922415249966 1.0589380822297558 0.6387202339182368 0.9287371340281638 0.05187624753323031 0.16584042241345226 0.5189840041825953 0.03200146158177708 0.07377914897810288 1.4369711154654155e-07 6.842551961524827 -0.420217848311519 LFIGGLSFETTDESLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFIGGLSFETTDESLR 16 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;F8W646;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 178136600.0 79728000.0 38812600.0 59596000.0 False True 77197078.28090078 54310673.58503509 43986019.758323215 1.0 0.7035327604940201 0.5697886595949803 26.202042910287524 -13.999999999955968 0.10742621796004166 2.4374584654518423 0.3150926061647224 0.9997561459751378 0.0028072840831304697 12.028378856293385 0.09902775878796055 3.7689514542502116 0.2263921093781264 1.0000000001013882e-14 13.999999999955968 -2.12236585928712 LFIGGLSFETTDESLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFIGGLSFETTDESLR 16 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;F8W646;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 259202000.0 49200000.0 118050000.0 91952000.0 False True 74639997.00179924 96983055.1711401 73777646.89600669 1.0 1.2993443068975776 0.9884465415269006 26.15344559244985 -6.654832434911649 1.991667817986731 1.1935054598714927 0.9897629778691269 0.21367527229028105 0.12761456345682576 0.4968315605102857 3.783033812092145 0.051871783978754187 0.14136126702957824 2.2139487590486632e-07 6.654832434911649 -0.20374248200236578 LFIGGLSFETTDESLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFIGGLSFETTDESLR 16 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;F8W646;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 34872600.0 8477800.0 10285000.0 16109800.0 False True 11612271.763930514 9830574.692053191 12304997.031745607 1.0 0.8465677424626294 1.059654586277149 23.469146905316215 -6.713486639150141 1.782802629600171 0.9060116371798724 1.0592068981945606 0.4816542911257512 0.0646213254926938 0.36809922295026043 2.282726033138124 0.028822329719288196 0.07291363900042915 1.9342533640294064e-07 6.713486639150141 0.15319526101468817 LFIGGLSFETTDESLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFIGGLSFETTDESLR 16 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;F8W646;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 143587000.0 79728000.0 26740000.0 37119000.0 False True 66297364.54926956 26595946.312525567 44880411.28113525 1.0 0.40116144123286407 0.6769561895297048 25.9824481857218 -10.440645751835696 6.127314611582089 1.0001723082437042 0.5390588153813058 0.7883334711996866 0.11259273451109686 0.0002651234689425861 2.420290908099653e-05 0.10905754932066904 0.03633914880545254 3.625385956965387e-11 10.440645751835696 -0.46111349286239833 LFIGGLSFETTDESLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFIGGLSFETTDESLR 16 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;F8W646;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 178707300.0 49200000.0 68299300.0 61208000.0 False True 63690369.8769906 64498383.91509014 50068772.047115594 1.0 1.0126865967282042 0.7861278266057601 25.924571914542298 -6.89364125470274 1.0005706014694904 1.0111320463126359 0.7651909357819128 0.9831291577992182 0.013500497111421128 0.11623934084678357 0.20497717417706482 0.01022828306906868 0.02585788545718383 1.2774936359391953e-07 6.89364125470274 -0.2459411105307231 LFIGGLSFETTEESLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFIGGLSFETTEESLR 16 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 14461200.0 6034500.0 6363300.0 2063400.0 False True 7911287.938181118 5413920.443949134 1849899.1615304227 1.0 0.6843285804098601 0.23383034165682667 22.915481150339744 -7.252869360206595 0.4037220168027798 1.0295561562226905 3.2730825456620246e-11 0.9995676600853143 0.006537200656754022 0.0957456019968951 0.029378342266452848 0.01046658429465468 0.04848004771468337 5.586382130016014e-08 7.252869360206595 -1.0295561561899595 down LFIGGLSFETTEESLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFIGGLSFETTEESLR 16 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 109815000.0 52541000.0 26616000.0 30658000.0 False True 50873114.7144894 37243907.60060637 22627750.07971463 1.0 0.7320941092289512 0.4447879829396394 25.600400090348085 -6.970235275606378 0.25250281168133476 1.0884156897215063 0.08002466679592844 0.9999841596470687 0.0009022878838480629 0.07622642515910386 0.00875653947677453 0.006300844767363122 0.027424381206644588 1.0709389753234866e-07 6.970235275606378 -1.008391022925578 down LFIGGLSFETTEESLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFIGGLSFETTEESLR 16 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 338569000.0 75646000.0 179600000.0 83323000.0 False True 114760512.46337596 147548976.77879536 66854172.528231755 1.0 1.2857120764939363 0.5825537991525371 26.77405107469107 -6.796382416289355 1.4705416033002852 1.158368927353015 0.5736812990524355 0.8214104448346667 0.12202007116662032 0.22595698125480493 0.9649930984999721 0.06528797934843848 0.15218898109072157 1.59815016405108e-07 6.796382416289355 -0.5846876283005796 LFIGGLSFETTEESLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFIGGLSFETTEESLR 16 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 18498400.0 6034500.0 3565400.0 8898500.0 False True 8265617.726230693 3407868.8387988824 6796857.570360174 1.0 0.41229451344986734 0.8223048531255623 22.978691211862635 -9.816737434601041 5.642603001449564 1.0000000805708447 0.6172996832852641 0.5373855334867707 0.16738602025387328 21129149367444.715 4436472879321.9795 23070492.05155885 0.05758237701218644 1.524974442940628e-10 9.816737434601041 -0.3827003972855806 LFIGGLSFETTEESLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFIGGLSFETTEESLR 16 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 82881000.0 52541000.0 14445000.0 15895000.0 False True 43690169.46095693 14367181.917891977 19218571.009823687 1.0 0.3288424397330616 0.43988318761267514 25.38080536578236 -10.132187683034145 5.599761094565854 1.0000085071272076 0.3843628136768855 0.976181901387963 0.045332195493969794 4.814674596541232e-06 7.460808844663021e-07 0.04389331531806153 0.014630903182888361 7.375854091682299e-11 10.132187683034145 -0.615645693450322 LFIGGLSFETTEESLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFIGGLSFETTEESLR 16 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 232461000.0 75646000.0 86983000.0 69832000.0 False True 97925238.20558585 82142319.58579776 57123292.53682805 1.0 0.8388268549661 0.5833357526984256 26.54517739678352 -6.964322899673536 0.36948921670519824 1.019761574414024 0.39351491097516966 0.9998984985840651 0.0017283108493698295 0.07819149049718761 0.015674735191554972 0.00337020121795243 0.02170466480528518 1.0856181620601996e-07 6.964322899673536 -0.6262466634388544 LFIGMISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFIGMISK 8 0 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4 G5EA30 CELF1 CUGBP Elav-like family member 1 0 13240400.0 3340600.0 4299600.0 5600200.0 False True 4379558.950416419 3658116.4397095283 5020745.024911641 1.0 0.8352705103699326 1.146404257084896 22.06235415785252 -6.762860439760768 1.6017210777737314 0.9046571855269905 1.1477039647850942 0.7025366116464726 0.06931691129884149 0.27813403713814755 1.4069593996043228 0.03413551263372043 0.08180241604268454 1.7263925779535292e-07 6.762860439760768 0.2430467792581037 LFIGMISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFIGMISK 8 0 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4 G5EA30 CELF1 CUGBP Elav-like family member 1 0 9590500.0 3567300.0 2124200.0 3899000.0 False True 3454058.014141299 2972404.1375566586 2877734.9325072537 1.0 0.8605542018655461 0.8331460909821102 21.719860883809734 -13.99999999999997 0.22872181775141154 1.875104898928932 0.8196569252657069 0.9995080692109135 0.0016203690955861117 13.25195352854786 0.15143947905937907 5.262770499522185 0.01434141672926522 1.0000000000000696e-14 13.99999999999997 -1.0554479736632252 LFIGMISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFIGMISK 8 0 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4 G5EA30 CELF1 CUGBP Elav-like family member 1 0 12329300.0 3340600.0 3452800.0 5535900.0 False True 4575710.096320539 3300243.8791172854 4228434.435439333 1.0 0.7212528350017426 0.9241045316309572 22.125564219375413 -10.301513619058552 5.513718958191573 1.0000249748083472 0.8226786833163467 0.5046645224402596 0.08281385836658578 2.5428110276961114e-05 3.221324366138337e-06 0.08019545858669228 0.026728057857411724 4.994435178928162e-11 10.301513619058552 -0.17734629149200043 LFIGMISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFIGMISK 8 0 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4 G5EA30 CELF1 CUGBP Elav-like family member 1 0 7607100.0 3567300.0 1773200.0 2266600.0 False True 2966368.0081854477 1763647.4196473595 2740535.580425694 1.0 0.5945477482162429 0.9238690455342737 21.50026615924401 -9.938995077705862 6.643973344226679 1.0000000214957654 0.7592083968752548 0.41616855312072776 0.13444485664344052 4.28392712719626e-08 6.861040870085541e-09 0.13017568529929957 0.043391890896938845 1.1508134321912335e-10 9.938995077705862 -0.24079162462051062 LFIGMVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFIGMVSK 8 0 Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3;V9GYD9 Q5VZZ6 CELF2 CUGBP Elav-like family member 2 0 8938300.0 2422100.0 2357600.0 4158600.0 False True 3175396.555649767 2005855.2698528238 3728307.9641079893 1.0 0.6316865420427386 1.1741235775652854 21.598505341726867 -6.723805038311945 1.7452263878846008 0.7768497915061742 1.1734909988169795 0.5306538247560302 0.15491884244748882 0.34794269790448085 2.0730152295989863 0.07042212247827055 0.1760261553812317 1.8888390886554607e-07 6.723805038311945 0.3966412073108053 LFIIQACR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFIIQACR 8 0 P42574 P42574 CASP3 Caspase-3;Caspase-3 subunit p17;Caspase-3 subunit p12 0 10097600.0 1254500.0 5787600.0 3055500.0 False True 1644661.648595281 4924112.639888098 2739346.1704256115 1.0 2.9939973635877166 1.6655986188802478 20.64935938240213 -10.064986227342935 4.802086070375025 0.9999616735209971 2.3297979912507083 0.5719441403409423 0.5423165166538022 0.0002498410878666599 4.864734801717584e-05 0.5251125735819315 0.17503190310406816 8.610210570669041e-11 10.064986227342935 1.3298363177297112 LFIIQACR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFIIQACR 8 0 P42574 P42574 CASP3 Caspase-3;Caspase-3 subunit p17;Caspase-3 subunit p12 0 10199100.0 1254500.0 3917200.0 5027400.0 False True 1718322.5515877728 3744125.1515518483 3840031.6625530976 1.0 2.1789419850727 2.2347560177248518 20.712569443925023 -10.836925478082154 0.5506704960494787 6.615747597713512e-20 2.2300030519692653 0.9998327471840432 0.00736344961951491 2.4963440949549884 0.26798529334997745 3.2736997444940994 0.010405269606216338 1.4557088486837584e-11 10.836925478082154 2.2300030519692653 LFIPWTNQK(ub)IR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFIPWTNQKIR 11 1 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;J3QRY6;C9J979;Q96HV7 Q5TA45-4 CPSF3L Integrator complex subunit 11 1 3445340.0 591040.0 1775700.0 1078600.0 True False 774859.1636395019 1510772.4816243863 966996.8186617788 1.0 1.9497381621304064 1.2479646160726927 19.563574588200673 -10.16277005542807 4.586452673865933 0.9999196382790602 1.5988513891081195 0.4926224037961595 0.28649785052272664 0.0002536654672111685 4.630567667405971e-05 0.27744021732089075 0.09246678364236235 6.874323163629195e-11 10.16277005542807 0.5989317508290594 LFIPWTNQK(ub)IR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFIPWTNQKIR 11 1 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;J3QRY6;C9J979;Q96HV7 Q5TA45-4 CPSF3L Integrator complex subunit 11 1 5178310.0 961510.0 1417900.0 2798900.0 True False 930987.3913539646 1984074.8642508194 2065784.1247998332 1.0 2.131151165608501 2.218917403162139 19.828402103494472 -10.819510425540654 0.47262341245749884 1.448589923042792e-16 2.2177367150598073 0.99966760415854 0.01011995774778484 2.4510689652153745 0.22789980824264663 2.7771077950191145 0.018820109426053853 1.5152684281911256e-11 10.819510425540654 2.2177367150598073 LFIPWTNQK(ub)IR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFIPWTNQKIR 11 1 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;J3QRY6;C9J979;Q96HV7 Q5TA45-4 CPSF3L Integrator complex subunit 11 1 14273200.0 2777400.0 5660900.0 5834900.0 True False 4213518.8551381575 4650668.166186425 4681629.457472481 1.0 1.1037492238856812 1.1110973080762385 22.00659415046157 -13.498729892349964 0.38092263272283955 5.679380266051243e-07 1.111744589687933 0.9997964087561102 0.0007237998975071998 16.333338599816738 0.2006248502469237 13.192044713985688 0.001986806354233041 3.171539375516424e-14 13.498729892349964 1.1117440217499064 LFIPWTNQK(ub)IR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFIPWTNQKIR 11 1 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;J3QRY6;C9J979;Q96HV7 Q5TA45-4 CPSF3L Integrator complex subunit 11 1 4633640.0 591040.0 1437000.0 2605600.0 True False 809563.4602554305 1373508.5884764649 1990210.9440164606 1.0 1.6966039796844343 2.458375460014606 19.626784649723565 -6.969978065946103 0.2587094105989722 0.7827338636014463 3.394808219441561 0.9999822111860069 0.0025119474747048367 0.07630981704819084 0.009055603530297749 0.016035704570620406 0.07201432398403154 1.0715734237140916e-07 6.969978065946103 2.612074355840115 LFIPWTNQK(ub)IR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFIPWTNQKIR 11 1 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;J3QRY6;C9J979;Q96HV7 Q5TA45-4 CPSF3L Integrator complex subunit 11 1 7225210.0 961510.0 3588900.0 2674800.0 True False 799538.1671152939 3569565.8833591235 3234088.3131221426 1.0 4.464534690367558 4.044945502465032 19.60880737892875 -10.013244649190911 5.578014093150652 0.9999898051499065 4.254740096418514 0.987688885248752 0.17129656866615303 2.171828297708894e-05 3.8414626624896145e-06 0.16585770549963608 0.05528572980773695 9.699634081151136e-11 10.013244649190911 3.2547502912686075 LFIPWTNQK(ub)IR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFIPWTNQKIR 11 1 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;J3QRY6;C9J979;Q96HV7 Q5TA45-4 CPSF3L Integrator complex subunit 11 1 18261200.0 2777400.0 3021800.0 12462000.0 True False 3595399.0507388986 2853634.1736243134 10194043.870918082 1.0 0.7936905287433551 2.835302487167059 21.77772047255402 -6.882014656197311 1.0685442309044908 0.8683979258766061 2.98567203436331 0.9752726386305508 0.14430315518119347 0.12585844335347768 0.26165323079838215 0.10383702395386381 0.25243077726272545 1.3121556167708076e-07 6.882014656197311 2.117274108486704 up LFIQK(ub)EEQLQQILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFIQKEEQLQQILK 14 1 H0YJF2;P51948-2;P51948;H0YJ92 H0YJF2 MNAT1 CDK-activating kinase assembly factor MAT1 1 12251500.0 5873600.0 4053200.0 2324700.0 True False 5687145.783046091 5671663.8971587755 1715791.3304949 1.0 0.9972777406316067 0.3016963861924963 22.439273355816177 -6.907756395256859 0.9108539532899881 1.0230949137531145 0.2159812524300092 0.9900474426104987 0.03277634372625661 0.10592146131065777 0.14694468756350687 0.02654015624047182 0.0721746412768346 1.2366408963530657e-07 6.907756395256859 -0.8071136613231052 down LFISGLPFSCTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFISGLPFSCTK 12 0 A0A499FI31;Q15020-4;Q15020;H0YHU8 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 12177500.0 2540900.0 4510900.0 5125700.0 False True 3331144.506110602 3837891.303350479 4595341.733186241 1.0 1.1521239310724312 1.379508371599195 21.667586509264734 -6.9653156079243805 0.35259335323531354 0.9786714317359482 1.5606642984349997 0.9999195033940587 0.0013991327239864363 0.07785402447387302 0.014483201992882737 0.003101228685353921 0.019511170920420286 1.0831394951961812e-07 6.9653156079243805 0.5819928666990515 LFISGLPFSCTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFISGLPFSCTK 12 0 A0A499FI31;Q15020-4;Q15020;H0YHU8 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 12857100.0 2540900.0 4038200.0 6278000.0 False True 3480339.395240632 3859778.971458361 4795265.699468579 1.0 1.109023728184847 1.3778155389172995 21.730796570787625 -6.955759427997285 0.49156988704562526 0.9942005232017235 1.5040670776629212 0.999579157012971 0.003257136943225661 0.0812522241118329 0.027004645948600643 0.003883191005662136 0.022169227820688114 1.1072369542113348e-07 6.955759427997285 0.5098665544611978 LFIYNPTTGEFLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFIYNPTTGEFLGR 14 0 P54709;H7C547;F8WBY4 P54709 ATP1B3 Sodium/potassium-transporting ATPase subunit beta-3 0 17683900.0 4082400.0 6172200.0 7429300.0 False True 5352065.934017835 5251331.819047167 6660587.302877774 1.0 0.981178461511395 1.2444890225553746 22.351664458490138 -6.889726826374999 1.0239719061878554 0.9857592640975538 1.2670174880014213 0.9807237743269829 0.016651761386007904 0.11936609466896729 0.22313203270768778 0.012394896812319025 0.03087120341790823 1.2890601226681513e-07 6.889726826374999 0.28125822390386757 LFIYNPTTGEFLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFIYNPTTGEFLGR 14 0 P54709;H7C547;F8WBY4 P54709 ATP1B3 Sodium/potassium-transporting ATPase subunit beta-3 0 15121800.0 5117800.0 4751000.0 5253000.0 False True 4955338.240342088 6648099.076137691 3877081.7133779447 1.0 1.34160348975063 0.7824050600247812 22.240552105244443 -6.741391820061257 1.6817415031576068 1.2029243619780101 0.7819853011338317 0.611133072727956 0.1435230277291296 0.3152947666952995 1.7514752679830587 0.06750156646804076 0.16538135628477574 1.8138784449584782e-07 6.741391820061257 -0.4209390608441784 LFIYNPTTGEFLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFIYNPTTGEFLGR 14 0 P54709;H7C547;F8WBY4 P54709 ATP1B3 Sodium/potassium-transporting ATPase subunit beta-3 0 20426900.0 4082400.0 6174500.0 10170000.0 False True 5591773.602711776 5901690.173658962 7768055.457724678 1.0 1.0554236621448496 1.3891934848645333 22.41487452001303 -6.935756467406096 0.697920727568669 0.9958410676773017 1.468975732102517 0.9975536469332286 0.008502265360264095 0.08975681298341882 0.06383083443875619 0.008031034495180119 0.029303812146323827 1.1594273280160046e-07 6.935756467406096 0.47313466442521523 LFIYNPTTGEFLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFIYNPTTGEFLGR 14 0 P54709;H7C547;F8WBY4 P54709 ATP1B3 Sodium/potassium-transporting ATPase subunit beta-3 0 8448400.0 5117800.0 1435200.0 1895400.0 False True 4255677.456981885 1427468.292735103 2291719.3766605747 1.0 0.33542680505384437 0.5385087097944344 22.02095738067872 -10.0953277663564 5.37287152202514 1.000007759711681 0.43696775742384164 0.9110997247912572 0.0829078404357602 7.706551361886166e-06 1.2975568946823687e-06 0.08027627704435406 0.0267583904396266 8.029199218267055e-11 10.0953277663564 -0.5630400022878393 LFK(ub)IQNLNASTVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFKIQNLNASTVR 13 1 A0A096LNM2;Q969U6-2;Q969U6 A0A096LNM2 FBXW5 F-box/WD repeat-containing protein 5 1 8503000.0 1460100.0 3865100.0 3177800.0 True False 1413749.9247183315 5408454.586230224 2345438.8480434814 1.0 3.8256091064392295 1.659019609504683 20.431095516716287 -6.578950651205923 2.2711627375978822 2.925393597607305 1.664312166701879 0.0 1.227858713157995 0.7025096142092068 6.8144054271548065 0.45427156586615286 1.3727936866546295 2.6366309686476016e-07 6.578950651205923 -1.2610814309054261 LFK(ub)IQNLNASTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFKIQNLNASTVR 13 1 A0A096LNM2;Q969U6-2;Q969U6 A0A096LNM2 FBXW5 F-box/WD repeat-containing protein 5 1 13838800.0 2178400.0 4238300.0 7422100.0 True False 3304792.062372348 3481942.251010952 5955118.681777999 1.0 1.053604034775924 1.8019647134782548 21.65612806949232 -6.921326132169826 0.8148301800547176 0.9842640908013336 1.92640446784257 0.9945414747900849 0.02704591400169996 0.09739766987214553 0.1016166493443838 0.02346799233965701 0.07121431976203194 1.1985988807861917e-07 6.921326132169826 0.9421403770412364 LFK(ub)IQNLNASTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFKIQNLNASTVR 13 1 A0A096LNM2;Q969U6-2;Q969U6 A0A096LNM2 FBXW5 F-box/WD repeat-containing protein 5 1 4229420.0 742720.0 1457600.0 2029100.0 True False 1017323.6552533042 1393198.4123613741 1549868.370626269 1.0 1.3694741149162413 1.5234761942504582 19.956347306085608 -11.968548444040302 0.14595469313027984 1.8193876037002327e-17 1.7231249287861001 0.9996214447261657 0.004273812425789925 5.363616729596927 0.09939311327707286 1.796227999612565 0.15561117308807715 1.0751066692908917e-12 11.968548444040302 1.7231249287861001 LFK(ub)IQNLNASTVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFKIQNLNASTVR 13 1 A0A096LNM2;Q969U6-2;Q969U6 A0A096LNM2 FBXW5 F-box/WD repeat-containing protein 5 1 6178000.0 1460100.0 2488700.0 2229200.0 True False 1214137.8433974062 2475292.879131724 2695315.4133437523 1.0 2.038724756494986 2.21994185256734 20.211500792150563 -10.716727038712202 0.34445919047531953 1.5775951737948315e-15 2.2543830114711034 0.9992357693713105 0.014858724191630208 2.3452486358625553 0.1682258547234707 2.0142011328206597 0.05487159949840927 1.9198750348570738e-11 10.716727038712202 2.2543830114711016 LFK(ub)PPQPPAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFKPPQPPAR 10 1 A0A087WZK9;B3KS98;O15372 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 13138300.0 2504500.0 4325800.0 6308000.0 True False 3799509.6034757323 3553827.1923703356 5061221.035105384 1.0 0.9353383892277439 1.332072178597853 21.857381793593785 -6.865103336590801 1.1597792117635337 0.9643207453574832 1.3532342596747122 0.9595417422899885 0.03495808224799147 0.14163113067145683 0.3591615095173804 0.023456862427103757 0.055105991681118606 1.364258484537859e-07 6.865103336590801 0.388913514317229 LFK(ub)PPQPPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFKPPQPPAR 10 1 A0A087WZK9;B3KS98;O15372 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 10084100.0 2504500.0 2893400.0 4686200.0 True False 3242124.621075667 2732379.7464969885 3833359.684472507 1.0 0.8427744352376078 1.1823603755245784 21.628508115686234 -6.780826910133757 1.5328068221437838 0.9110700884858146 1.1851128589390765 0.7702500586476788 0.06651168581420687 0.24929370432270886 1.1569762771183583 0.034175783944493394 0.08057960633831689 1.6564300089760923e-07 6.780826910133757 0.27404277045326186 LFKPGQEAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFKPGQEAVK 10 1 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 18722300.0 8045300.0 2082500.0 8594500.0 False True 7789906.355274562 2914053.1100940336 6343342.620526691 1.0 0.3740806342454839 0.8143028081758134 22.89317455465951 -10.287472029191184 5.842757393368501 1.0000278735852302 0.5941917212107354 0.5311806475397691 0.17971994993134954 6.525864394239351e-05 7.958368923915616e-06 0.17402502008777135 0.05800436442211124 5.158553877550503e-11 10.287472029191184 -0.4058361523744948 LFKPGQEAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFKPGQEAVK 10 1 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 85056800.0 1819300.0 81780000.0 1457500.0 False True 2760011.108645798 67185720.04994352 1169424.4861550578 1.0 24.34255421635178 0.4237028186197544 21.396242642978326 -12.479439256993814 5.946597267817346e-11 8.870592710224868 13.619038358724794 0.0 11.45430754973925 1183667568.6477997 0.9606584670339445 578032796.0727032 578032787.7191573 3.3155894037197855e-13 12.479439256993814 4.748445648499926 LFKPGQEAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFKPGQEAVK 10 1 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 6400500.0 1819300.0 1924300.0 2656900.0 False True 2355119.713764409 1817211.0134043512 2173371.462096156 1.0 0.7716002727095906 0.9228284445134436 21.167368965070775 -10.132780397695983 5.916379636540774 1.0000011305230483 0.8472143587114953 0.5764395740200721 0.06173864260891334 9.206864081801358e-07 1.3490288477903365e-07 0.05977862635879353 0.01992606122014556 7.365794569504359e-11 10.132780397695983 -0.15278677181155298 LFKPGQEAVK(ub)YQGPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFKPGQEAVKYQGPR 15 2 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 1 22167600.0 2285000.0 5324600.0 14558000.0 True False 3466512.0558762476 4374383.528710311 11680604.919001933 1.0 1.2618976822235735 3.3695555448023295 21.725053347281317 -6.929985542489865 0.7469112985412113 0.9679308907680464 3.8020864745893372 0.9965353487022656 0.06243369111920028 0.09264556962925459 0.07771727193668655 0.05687495200574548 0.19072227810543424 1.1749366675157877e-07 6.929985542489865 2.834155583821291 up LFLAGYDPTPTMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFLAGYDPTPTMR 13 0 O75436 O75436 VPS26A Vacuolar protein sorting-associated protein 26A 0 7491900.0 1782500.0 2282500.0 3426900.0 False True 2336874.761754552 1941959.897115314 3072317.2611459796 1.0 0.8310072618770843 1.314711986892806 21.156148988324208 -6.81232899446276 1.4047753250492627 0.9081501701763235 1.3236277397431733 0.8658011649865721 0.0734261534747935 0.2036472329484544 0.7916183325175161 0.0410945519486167 0.09496138674753637 1.5405329989150756e-07 6.81232899446276 0.4154775695668498 LFLAGYDPTPTMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFLAGYDPTPTMR 13 0 O75436 O75436 VPS26A Vacuolar protein sorting-associated protein 26A 0 6187300.0 1782500.0 2548800.0 1856000.0 False True 2441538.4202512573 2436185.588245524 1417651.0255198604 1.0 0.9978075987003382 0.5806384260682537 21.2193590498471 -6.908053342148191 0.9088916881642936 1.0137249848838703 0.5289126782600703 0.990165926512011 0.019553154682381984 0.10571933805491292 0.1458550263737868 0.0158559178195205 0.04320094663962578 1.2357956377269482e-07 6.908053342148191 -0.48481230662380004 LFLFHTSLPIAEAPGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFLFHTSLPIAEAPGK 16 0 G5EA31;P53992 G5EA31 SEC24C Protein transport protein Sec24C 0 11964000.0 3681900.0 5666500.0 2615600.0 False True 4827006.555570317 4821080.287844003 2344962.8026068527 1.0 0.9987722685564876 0.48580062521373396 22.202697355435955 -6.907423180503865 0.9131059285405807 1.0172057690765965 0.423036030258134 0.9899122241940362 0.024316727840088672 0.10614669427752199 0.1481936770211357 0.019658185278830804 0.05334370961848425 1.2375900797498883e-07 6.907423180503865 -0.5941697388184626 down LFLFHTSLPIAEAPGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFLFHTSLPIAEAPGK 16 0 G5EA31;P53992 G5EA31 SEC24C Protein transport protein Sec24C 0 9213700.0 4205500.0 2214800.0 2793400.0 False True 4071998.7044743113 3099181.190029423 2061724.7397962941 1.0 0.7610958192653754 0.506317631567729 21.95730567173759 -6.970308121147244 0.250716718727859 1.0801451094156413 0.1797994098915988 0.9999846866384873 0.0007888064444037381 0.07620283710915604 0.008671640524195598 0.005655013642523615 0.0243895751998757 1.0707593585201009e-07 6.970308121147244 -0.9003456995240425 LFLFHTSLPIAEAPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFLFHTSLPIAEAPGK 16 0 G5EA31;P53992 G5EA31 SEC24C Protein transport protein Sec24C 0 19763900.0 3681900.0 6012000.0 10070000.0 False True 5043197.929606233 5746369.960974604 7691673.398160018 1.0 1.1394297906176516 1.5251579465096614 22.265907416958846 -6.953257091795402 0.521864021410349 0.9935386151129579 1.688317714480354 0.9994327149565952 0.005290288022219429 0.08220365048499698 0.030749306396180134 0.005975591904843062 0.031867358779909774 1.1136350934710379e-07 6.953257091795402 0.6947790993673961 LFLFHTSLPIAEAPGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFLFHTSLPIAEAPGK 16 0 G5EA31;P53992 G5EA31 SEC24C Protein transport protein Sec24C 0 12462200.0 4205500.0 3585000.0 4671700.0 False True 3497059.5852392237 3565686.8934332114 5648530.870499745 1.0 1.0196242890694964 1.61522294167983 21.737710947171866 -6.91390865434938 0.8686981431231799 0.983759478277682 1.6989924651205173 0.992314723381384 0.025029069207536562 0.10188986822739086 0.1251686874072174 0.02089615404252616 0.05937099734468978 1.2192460173542882e-07 6.91390865434938 0.7152329868428353 LFLIYYISTQQAPSEADLEQYKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFLIYYISTQQAPSEADLEQYKK 23 1 Q8WVM8;Q8WVM8-2;Q8WVM8-3 Q8WVM8 SCFD1 Sec1 family domain-containing protein 1 0 54514000.0 13464000.0 12453000.0 28597000.0 False True 20425872.35024847 10230664.854266915 22944790.415489648 1.0 0.5008679521167411 1.1233199748852114 24.283894358665833 -6.693219381093706 1.855078802065733 0.6880201386188609 1.1212489570665392 0.38546401577991096 0.2109625164929533 0.4097989741857874 2.7366826288176043 0.09089415704664322 0.2357297633530892 2.0266587071580221e-07 6.693219381093706 0.43322881844767824 LFLQFTTGTDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFLQFTTGTDR 11 0 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG63;S4R306 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 0 45767000.0 11750000.0 12558000.0 21459000.0 False True 17825609.040063817 10316926.783898158 17217619.244186196 1.0 0.5787699461325795 0.9658923409286528 24.087448033675606 -10.437745458851214 8.725254610480068 1.0000028280663789 0.7723311435306162 0.3156111423993123 0.1580420558757736 8.694482704380402e-06 5.603196736795097e-07 0.1530254615558455 0.05100785420060445 3.64967792843939e-11 10.437745458851214 -0.2276716845357627 LFLVQLQEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFLVQLQEK 9 0 O43809;H3BND3 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 42569200.0 8908200.0 19302000.0 14359000.0 False True 13514390.676655022 15857407.292785667 11520937.356226739 1.0 1.1733719760061405 0.8524940289115803 23.687993130757835 -6.759995464119731 1.612838701631163 1.1007067137473938 0.8513363713279218 0.6908120618872142 0.07291977960534818 0.28292617209002857 1.4505678695180373 0.03567524568018335 0.08572159303828435 1.7378189788709685e-07 6.759995464119731 -0.24937034241947198 LFLVQLQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFLVQLQEK 9 0 O43809;H3BND3 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 34235600.0 7621100.0 8439500.0 18175000.0 False True 10438826.622483518 8066614.98430559 13882439.32587471 1.0 0.7727511219442448 1.3298850366931294 23.315456218929516 -6.79595047195741 1.4722708534302906 0.8739651866831013 1.336838671517629 0.8200891708024867 0.0970186708342803 0.22659093211981077 0.9700061279732555 0.05185053739035554 0.12090109466350017 1.5997404566652965e-07 6.79595047195741 0.4628734848345277 LFLVQLQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFLVQLQEK 9 0 O43809;H3BND3 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 16112100.0 7695900.0 4259500.0 4156700.0 False True 6399481.83617705 4236553.228055448 5025846.751590698 1.0 0.6620150406718396 0.7853521394777581 22.609523664649085 -10.45028308748504 7.610911510879164 1.000018095002661 0.7236835905473509 0.8699970646995064 0.05035215973828878 1.546131452605435e-05 1.1166537129215655e-06 0.04875645714340391 0.016251089675997345 3.545821855107438e-11 10.45028308748504 -0.27633450445531005 LFLVQLQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFLVQLQEK 9 0 O43809;H3BND3 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 38286200.0 8908200.0 18299000.0 11079000.0 False True 11531840.506874124 17280644.563886225 9062735.680139745 1.0 1.4985157446103459 0.7858880527126136 23.459119452850285 -6.71861543726308 1.764259628683117 1.3037225178041998 0.7870760701320005 0.5061247258981082 0.20981123647023953 0.3579469605755537 2.176650964261511 0.09445440563076532 0.23750627105069347 1.911545160490057e-07 6.71861543726308 -0.5166464476721992 LFLVYRPNTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFLVYRPNTGK 11 1 A3KN83-3;A3KN83-2;A3KN83 A3KN83-3 SBNO1 Protein strawberry notch homolog 1 0 8157900.0 3465800.0 2511300.0 2180800.0 False True 4543697.3628549455 2136623.828970732 1955151.7357107461 1.0 0.4702390274576354 0.4302997271988784 22.115435315335663 -13.999999999999998 0.3667075190306974 8.228219684761374 0.4259433430707231 0.9997852114828932 0.0038054554853093865 22.439999277952307 0.19626746615098165 127.32266039617075 0.011278602214140506 1.0000000000000041e-14 13.999999999999998 -7.802276341690651 LFLVYRPNTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFLVYRPNTGK 11 1 A3KN83-3;A3KN83-2;A3KN83 A3KN83-3 SBNO1 Protein strawberry notch homolog 1 0 6618900.0 1356500.0 1069200.0 4193200.0 False True 1313438.6500105595 1496137.1358043405 3094875.126696438 1.0 1.1390993677491614 2.3563149498239273 20.324917383885857 -6.928466266175724 0.759273841396141 0.9803990488875974 2.5967172457880086 0.9962282377483571 0.037416232496068534 0.0934417313551761 0.08163837410042524 0.03378224114851071 0.11108003730910755 1.1790541027155191e-07 6.928466266175724 1.6163181969004112 up LFLVYRPNTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFLVYRPNTGK 11 1 A3KN83-3;A3KN83-2;A3KN83 A3KN83-3 SBNO1 Protein strawberry notch homolog 1 0 6824800.0 3465800.0 1482200.0 1876800.0 False True 4747199.919723322 1416711.503020053 1433538.4939093078 1.0 0.2984309755175894 0.3019755894318556 22.178645376858555 -10.491979873159169 6.198080448009843 1.000496846558193 0.3002032824747225 0.9999807578368118 0.0014470825708537082 9.941705500862844e-06 8.148615982513555e-07 0.0014020555352969536 0.00046704389145860273 3.221218071193324e-11 10.491979873159169 -0.7002935640834704 LFLVYRPNTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFLVYRPNTGK 11 1 A3KN83-3;A3KN83-2;A3KN83 A3KN83-3 SBNO1 Protein strawberry notch homolog 1 0 4249700.0 1356500.0 1718700.0 1174500.0 False True 1127989.853139225 1709441.0219647589 1420082.5197255677 1.0 1.5154755312801267 1.258949728823749 20.105322659320134 -10.029887547167586 4.29432629414665 0.999975005990667 1.387212629940395 0.7523474509964847 0.10472622061925382 24130816.97086342 38854343.83778399 8250.498139439078 0.038325873298781774 9.334959816889307e-11 10.029887547167586 0.38723762394972805 LFLWSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFLWSLR 7 0 Q05DH4 Q05DH4 FAM160A1 Protein FAM160A1 0 2856490.0 505890.0 1269500.0 1081100.0 False True 663226.6890457281 1080095.5484722422 969238.1426434717 1.0 1.6285465683329459 1.4613979784770768 19.339142538235464 -10.149581906717843 4.734132934388253 0.9999488790600553 1.5449722734083524 0.9340963367821207 0.06823812607703489 3.697359050959347e-05 6.6418119648651386e-06 0.06607748300960532 0.022023760487278755 7.086276486662985e-11 10.149581906717843 0.5450233943482972 LFLWSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFLWSLR 7 0 Q05DH4 Q05DH4 FAM160A1 Protein FAM160A1 0 4219390.0 505890.0 1620100.0 2093400.0 False True 692931.2041632026 1548518.6250457366 1598982.0349263356 1.0 2.234736458312277 2.3075624612075276 19.402352599758355 -10.779776784021442 0.5214099499588446 3.7472315724417845e-21 2.3031510230422185 0.999766734190538 0.00916325388278164 2.3784663929866223 0.2520044054021956 2.9936253654683735 0.014239069821709506 1.6604401108448022e-11 10.779776784021442 2.3031510230422185 LFMILWLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFMILWLK 8 0 Q9Y696;A0A2R8Y4M1;A0A5F9ZHK1;A0A2R8YGW2;A0A2R8Y615;Q9NZA1-3;Q9NZA1-2;Q9NZA1;Q96NY7-2;Q96NY7;O15247;A6PVS0 Q9Y696;O15247 CLIC4;CLIC5;CLIC6;CLIC2 Chloride intracellular channel protein 4;Chloride intracellular channel protein 5;Chloride intracellular channel protein 6;Chloride intracellular channel protein 2 0 13777500.0 2849200.0 5639100.0 5289200.0 False True 4322444.704421268 4632758.5465106 4243787.301661285 1.0 1.071791280932275 0.9818025658767763 22.043416077398213 -6.6941876114367815 1.8513526704468724 1.0448299728319677 0.9820952301844772 0.39018872411881433 0.030337233332974077 0.40772313425225065 2.712544035701272 0.013092870746989173 0.033918185888096856 2.0221454407353694e-07 6.6941876114367815 -0.06273474264749046 LFMILWLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFMILWLK 8 0 Q9Y696;A0A2R8Y4M1;A0A5F9ZHK1;A0A2R8YGW2;A0A2R8Y615;Q9NZA1-3;Q9NZA1-2;Q9NZA1;Q96NY7-2;Q96NY7;O15247;A6PVS0 Q9Y696;O15247 CLIC4;CLIC5;CLIC6;CLIC2 Chloride intracellular channel protein 4;Chloride intracellular channel protein 5;Chloride intracellular channel protein 6;Chloride intracellular channel protein 2 0 8945210.0 784510.0 2395900.0 5764800.0 False True 1074564.5475855914 2290041.215818207 4403272.96978281 1.0 2.1311341612410675 4.097727753699299 20.03532071536089 -6.9626886087163165 0.3957219705961294 0.886658580475194 5.413517461427455 0.9998572881233834 0.015289730184250828 0.07875430249350414 0.017682279173804636 0.025327766234724255 0.16503903943196296 1.0897111415507391e-07 6.9626886087163165 4.526858880952261 LFMILWLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFMILWLK 8 0 Q9Y696;A0A2R8Y4M1;A0A5F9ZHK1;A0A2R8YGW2;A0A2R8Y615;Q9NZA1-3;Q9NZA1-2;Q9NZA1;Q96NY7-2;Q96NY7;O15247;A6PVS0 Q9Y696;O15247 CLIC4;CLIC5;CLIC6;CLIC2 Chloride intracellular channel protein 4;Chloride intracellular channel protein 5;Chloride intracellular channel protein 6;Chloride intracellular channel protein 2 0 12417200.0 2849200.0 4308100.0 5259900.0 False True 3688345.566128488 4068350.4478757367 4302652.171131606 1.0 1.1030285462503788 1.1665534299834956 21.814542399490662 LFMLLLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFMLLLEK 8 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 4223100.0 1415800.0 1802400.0 1004900.0 False True 1856127.5106267028 1533488.9457001733 900922.5876814595 1.0 0.826176508305944 0.48537753065104455 20.82386439219803 -6.960432589886758 0.42930100529188475 1.0136378530526753 0.2848623377515136 0.9997858895755262 0.0031276686527388735 0.07954705853605795 0.020563668466147746 0.004440990045687876 0.028301455229288962 1.0953865653602924e-07 6.960432589886758 -0.7287755153011617 down LFMLLLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFMLLLEK 8 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 7464600.0 3250200.0 2249100.0 1965300.0 False True 3147024.180069535 3147177.3589015547 1450528.972263786 1.0 1.000048674183373 0.46092082210557905 21.58555683290884 -6.906872721845065 0.9167711907858668 1.0183878994540976 0.39571507667368094 0.9896868598047289 0.02580841644654153 0.10652241669076555 0.15025493538028528 0.020808272178582412 0.05626848802344705 1.2391596923422873e-07 6.906872721845065 -0.6226728227804166 down LFMLLLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFMLLLEK 8 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 21279300.0 5614700.0 8104500.0 7560100.0 False True 8517910.38955289 6658188.654252476 6065842.921290452 1.0 0.7816692533439494 0.7121280506460989 23.022068121796636 -13.999999999999998 0.16009198081542228 2.075457552335297 0.6438349529700463 0.9995361238415176 0.002641479546607887 12.010237101220058 0.12644473864278072 4.010719098585577 0.062249892903929994 1.0000000000000041e-14 13.999999999999998 -1.4316225993652507 LFMLLLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFMLLLEK 8 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 7628900.0 1415800.0 2643400.0 3569700.0 False True 1939259.5205563721 2526605.847445156 2726610.3802792304 1.0 1.3028714417347682 1.4060059271989382 20.88707445372092 -12.782372314114793 0.16570858079513784 1.8765239385286002e-10 1.5071567046055905 0.9995157428900847 0.0037917657339333814 7.548563902314093 0.11857056581826447 2.565641316860429 0.0869787926246458 1.6505462031442743e-13 12.782372314114793 1.5071567044179381 LFMLLLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFMLLLEK 8 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 17054300.0 5614700.0 6278600.0 5161000.0 False True 7268339.832283314 5929190.390667034 4221750.956331909 1.0 0.8157558022165851 0.5808411623216118 22.793194443889085 -6.967817393940684 0.30587190962620053 1.0380009090969575 0.35117326698235296 0.9999599958676026 0.0010849368706772132 0.07701757098636695 0.011552522887150087 0.0037882583338938033 0.020941086514514033 1.0769179258100296e-07 6.967817393940684 -0.6868276421146046 LFMVLWLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFMVLWLK 8 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 11295100.0 2463000.0 4927200.0 3904900.0 False True 3229016.8517259294 4192080.9660751745 3500858.4064457496 1.0 1.29825304684752 1.0841870969408287 21.62266353949192 -10.307362611807605 3.6980136117112985 0.9994769718983332 1.19122007196253 0.5154859743174594 0.087392058332837 20693790.698947284 77.45640535667778 92506.18664510406 0.029916626025981483 4.927622030345868e-11 10.307362611807605 0.19174310006419693 LFMVLWLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFMVLWLK 8 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 15832300.0 8957600.0 4436600.0 2438100.0 False True 8673245.891142348 6208157.516563354 1799488.4685678217 1.0 0.7157824872581448 0.20747578140331177 23.048140580613204 -7.186678276650102 0.4673524002712649 1.0151149298523012 4.999272827117361e-22 0.999394961752241 0.008063793622767428 0.0861543647426248 0.032196632744077906 0.009885049594038157 0.0459364141904921 6.50611481852734e-08 7.186678276650102 -1.0151149298523012 down LFMVLWLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LFMVLWLK 8 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 764662000.0 169945900.0 290639300.0 304076800.0 False True 257820355.0095137 238772446.1397846 243975887.19840407 1.0 0.9261194529461174 0.9463018821357267 27.941790928585977 -10.562479772927167 6.298886947741268 1.0001119070918247 0.9362106675409221 0.9301651356297199 0.008239442214065976 1.2971230034013519e-05 9.009840388442383e-07 0.007991781462133737 0.002659268539759657 2.7385471779141292e-11 10.562479772927167 -0.06390123955090266 LFMVLWLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFMVLWLK 8 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 14589600.0 2463000.0 5457600.0 6669000.0 False True 3373637.6600722885 5216465.186130239 5093919.552366362 1.0 1.5462434652862107 1.5099189852704016 21.685873601014812 -10.182957434471513 4.941642415428255 0.9999515659894663 1.5280812252793068 0.9964639347397201 0.014829406871960705 7.914143496322964e-06 1.3085463003550289e-06 0.014359824021863055 0.004786170486934096 6.562095787450672e-11 10.182957434471513 0.5281296592898405 LFMVLWLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFMVLWLK 8 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 13846500.0 8957600.0 2010000.0 2878900.0 False True 7448641.288964193 1999171.7310462387 3480864.679470362 1.0 0.26839414780359805 0.46731538604598455 22.82854585604748 -10.297552707360795 5.175106249843855 1.0001464122763906 0.36785476692540575 0.9308681750559262 0.08120925544974159 0.00013721545430771985 1.8625201652892063e-05 0.078648491803422 0.026210174492848272 5.0401944598627345e-11 10.297552707360795 -0.6322916453509848 LFMVLWLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LFMVLWLK 8 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 555703300.0 169945900.0 174341000.0 211416400.0 False True 219998317.68451336 164638770.09194413 172940784.51545224 1.0 0.7483637685268253 0.7861004862930654 27.712917250678426 -10.420833674826357 5.117231049912239 1.000253043470363 0.7672321274099342 0.9806684926208886 0.015405950515823741 4.4523406548532016e-05 5.039153610999761e-06 0.014932830132924213 0.004972249148351156 3.7946028203795315e-11 10.420833674826357 -0.23302091606042874 LFNESHGIFLGLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFNESHGIFLGLQR 14 0 J3KT10;Q9BW27;Q9BW27-3;J3KRC0;J3KSH3 J3KT10 NUP85 Nuclear pore complex protein Nup85 0 7460100.0 2761900.0 2163100.0 2535100.0 False True 3620877.6462776433 1840373.9116977602 2272792.170396328 1.0 0.5082673571115314 0.627690961259853 21.78790799659647 -10.003736557022219 7.187378925272089 1.0000000298525753 0.5679791591857256 0.945796193842016 0.048754482234586095 2.3345124410821254e-08 3.180776647057721e-09 0.047206327602298134 0.015735441478959684 9.914331657570074e-11 10.003736557022219 -0.4320208706668497 LFNESHGIFLGLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFNESHGIFLGLQR 14 0 J3KT10;Q9BW27;Q9BW27-3;J3KRC0;J3KSH3 J3KT10 NUP85 Nuclear pore complex protein Nup85 0 7826600.0 3436200.0 1469400.0 2921000.0 False True 3327119.7118807854 2056139.0828197703 2155902.471878347 1.0 0.6179937185540754 0.6479786297378637 21.66584234556288 -9.96824408593911 5.4152126393307585 1.000000949521387 0.6329861741450328 0.9950188074079714 0.012241288733781967 1.4033599337159967e-07 2.6728130429326082e-08 0.011852607490494691 0.003950858949695071 1.0758603793276614e-10 9.96824408593911 -0.3670147753763543 LFNESHGIFLGLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFNESHGIFLGLQR 14 0 J3KT10;Q9BW27;Q9BW27-3;J3KRC0;J3KSH3 J3KT10 NUP85 Nuclear pore complex protein Nup85 0 38477000.0 10102000.0 15138000.0 13237000.0 False True 15325472.555125535 12436505.62626615 10620701.148016794 1.0 0.8114924731705462 0.6930097006675823 23.869428223767088 -11.14697217536361 0.054625124160225226 2.018541460560417 6.39301385674255e-12 0.9999867705092483 0.0004597482887018472 3.7336902000146748 0.03530407071830726 0.9214278346919464 0.4479920159943181 7.1289870308023955e-12 11.14697217536361 -2.0185414605540237 LFNESHGIFLGLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFNESHGIFLGLQR 14 0 J3KT10;Q9BW27;Q9BW27-3;J3KRC0;J3KSH3 J3KT10 NUP85 Nuclear pore complex protein Nup85 0 8608700.0 3436200.0 2376400.0 2796100.0 False True 2857352.549470701 2363597.8615215346 3380751.582294307 1.0 0.8271985415168213 1.1831762177616345 21.446247620997156 -6.774709220621533 1.5564376736717194 0.9014829437826634 1.1855443459451331 0.7482391233663648 0.07292941522879703 0.25888339961453616 1.2382784442202162 0.03691993531967516 0.08751035508764325 1.6799284280993849e-07 6.774709220621533 0.2840614021624698 LFNESHGIFLGLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFNESHGIFLGLQR 14 0 J3KT10;Q9BW27;Q9BW27-3;J3KRC0;J3KSH3 J3KT10 NUP85 Nuclear pore complex protein Nup85 0 32451000.0 10102000.0 12043000.0 10306000.0 False True 13077238.140190233 11372796.463352194 8430413.748489948 1.0 0.8696634825667215 0.6446631664969674 23.640554545859537 -6.962817522525253 0.3937190403920614 1.0132587962841682 0.4929349993327371 0.9998608439441631 0.0017313726346991592 0.07870961542790951 0.01752184010824876 0.0028998301984086527 0.01889744176884032 1.0893877251310109e-07 6.962817522525253 -0.520323796951431 LFNHLSAVSESIQALGWVAMAPK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LFNHLSAVSESIQALGWVAMAPK 23 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 407897700.0 144392000.0 152566700.0 110939000.0 False True 219053220.46918282 125339980.37593226 89011858.02370904 1.0 0.5721896263723981 0.4063480912677636 27.706706184080538 -13.999999999999998 0.1311333366949421 3.033460283551328 0.1774069592493765 0.9996405159408294 0.004741898721202896 11.935142899599558 0.11272225710040597 6.249173087927424 0.20369387560827026 1.0000000000000041e-14 13.999999999999998 -2.8560533243019517 LFNHLSAVSESIQALGWVAMAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFNHLSAVSESIQALGWVAMAPK 23 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 105300000.0 52584000.0 23218000.0 29498000.0 False True 43725925.86617991 23092920.025587812 35665895.41665804 1.0 0.528128783282075 0.8156693016818208 25.381985596749647 -10.350483660483295 5.983586905184458 1.0000426157399844 0.6718990424819484 0.6345060785640761 0.11738792507579031 6.674419621444062e-05 7.245202399392762e-06 0.11367509350101972 0.037886789905364836 4.461864111934577e-11 10.350483660483295 -0.328143573258036 LFNHLSAVSESIQALGWVAMAPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFNHLSAVSESIQALGWVAMAPK 23 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 283969000.0 134430000.0 112430000.0 37109000.0 False True 174022285.01146024 106173171.66608708 30355542.77049422 1.0 0.610112501735597 0.17443480166057557 27.374696826189357 -7.580434018363593 0.40469788863919354 1.0393055590173133 2.49597683034173e-13 0.9985985046667466 0.012623916038228341 0.12072871993731432 0.05546462467726108 0.022761663646962284 0.07077352298781814 2.627640709215611e-08 7.580434018363593 -1.0393055590170637 down LFNHLSAVSESIQALGWVAMAPKPGPYVK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LFNHLSAVSESIQALGWVAMAPKPGPYVK 29 1 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 234969000.0 62473900.0 40619700.0 131875400.0 False True 94777473.7538761 33370797.171835337 105810169.3869588 1.0 0.35209629303366585 1.1164063062256022 26.49804087138033 -6.682071832710435 1.8945350766026927 0.5908299412535949 1.1135457641523037 0.33364153930973006 0.27447310313257184 0.43392889863288214 3.0130055605161465 0.11617478312213739 0.30559131452343946 2.079352731787244e-07 6.682071832710435 0.5227158228987088 LFNHLSAVSESIQALGWVAMAPKPGPYVK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LFNHLSAVSESIQALGWVAMAPKPGPYVK 29 1 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 151500600.0 62473900.0 52617700.0 36409000.0 False True 80873695.09467727 49689478.74032434 29782935.587887682 1.0 0.6144084140356618 0.3682648054230906 26.26916719347278 -8.515801759885477 0.1709589896638906 1.3756370326837557 6.2469827997174535e-06 0.9998351359353115 0.00333826122251829 0.16177188548224494 0.043075173525607816 0.16362777673953896 0.13801976344787203 3.0492865637773148e-09 8.515801759885477 -1.375630785700956 down LFNLHLASLPPGHTLFSGISDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFNLHLASLPPGHTLFSGISDR 22 0 Q9NVU0-4;Q9NVU0;A0A0C4DH01;Q9NVU0-5;Q9NVU0-3;Q9NVU0-2 Q9NVU0-4 POLR3E DNA-directed RNA polymerase III subunit RPC5 0 43057800.0 31839000.0 5048000.0 6170800.0 False True 30828288.37278743 7063692.724972238 4554482.359968132 1.0 0.2291302273923018 0.14773711420152794 24.87775145554955 -13.999999999999998 0.31759856129895553 8.792269402821017 0.13114155260809096 0.9996885587415673 0.006777002411084262 17.82886612324654 0.1796186092560931 92.19260350493171 0.027355792862022665 1.0000000000000041e-14 13.999999999999998 -8.661127850212926 LFNLHLASLPPGHTLFSGISDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFNLHLASLPPGHTLFSGISDR 22 0 Q9NVU0-4;Q9NVU0;A0A0C4DH01;Q9NVU0-5;Q9NVU0-3;Q9NVU0-2 Q9NVU0-4 POLR3E DNA-directed RNA polymerase III subunit RPC5 0 47710900.0 31839000.0 9469500.0 6402400.0 False True 26475539.20685569 9418485.923951421 7741112.238647079 1.0 0.3557429312530322 0.2923873307419765 24.658156730983826 -13.999999999999998 0.32791131163995474 7.925591480686616 0.2808908539883277 0.9997104900278424 0.005439465290888825 18.64841659132875 0.18300430276960516 88.97424611721429 0.020462228611409807 1.0000000000000041e-14 13.999999999999998 -7.644700626698288 LFNWIVDNVNQALHSAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFNWIVDNVNQALHSAVK 18 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 0 1315411000.0 412900000.0 355298000.0 547213000.0 False True 626399487.0333914 291892295.9440556 439056110.69802225 1.0 0.46598425124268306 0.7009202909430505 29.222507790286784 -10.334366371777913 5.82236729842634 1.0000554755097155 0.5834522710928675 0.8073772717426346 0.09591223657602962 6.907717757190018e-05 7.897126230594959e-06 0.09287893994914942 0.030955541246371735 4.6305611976088477e-11 10.334366371777913 -0.41660320441684806 LFNWIVDNVNQALHSAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFNWIVDNVNQALHSAVK 18 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 0 810573000.0 412900000.0 186570000.0 211103000.0 False True 534507189.4758004 176187215.4917891 172684420.09969682 1.0 0.3296255297605607 0.3230722121231917 28.993634112379233 LFPDTPLALDANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFPDTPLALDANK 13 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 6420780.0 2446400.0 831880.0 3142500.0 False True 2368740.3710916555 1164054.0221968903 2319384.977020786 1.0 0.49142322071389594 0.9791638650342572 21.175688648077433 -10.749568666655284 10.10604612734513 1.0007796396698299 0.7352935428740766 0.2819837981154283 0.19911928423353056 0.003506913984839113 8.690237575426598e-05 0.1933006915808071 0.06426547264543374 1.7800464420058757e-11 10.749568666655284 -0.2654860967957533 LFPGFEIETVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFPGFEIETVK 11 0 P08243-2;P08243;P08243-3;F8WEJ5 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 5724400.0 1409600.0 2085300.0 2229500.0 False True 1847999.2505858173 1774181.3684357353 1998812.7268741322 1.0 0.9600552423781116 1.081609057060227 20.81753274102601 -6.818156761028756 1.3797238601551605 0.9784291047862933 1.0841616420324311 0.8801219301468433 0.017514774001710375 0.19588198851221097 0.7331823824899822 0.009976638912710618 0.02300781113575493 1.5199987786178e-07 6.818156761028756 0.10573253724613785 LFPGFEIETVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFPGFEIETVK 11 0 P08243-2;P08243;P08243-3;F8WEJ5 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 5456000.0 1409600.0 1946500.0 2099900.0 False True 1930767.2130076718 1860497.1937852737 1603946.868798037 1.0 0.9636051312923767 0.8307303221186737 20.8807428025489 -6.946974726524225 0.5911270871202179 1.0015307673794065 0.7861056800136718 0.9989419558508148 0.002366361833636943 0.0847238269475385 0.04116911153654422 0.0024504530669222533 0.011135371743128487 1.1298616643005805e-07 6.946974726524225 -0.21542508736573474 LFPGSPAIYK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFPGSPAIYKLK 12 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;C9J6W1;Q7Z3J3-2;C9J1W9;C9JF75;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RGPD5;RGPD6;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 1 7062100.0 2771200.0 2609900.0 1681000.0 True False 2304375.584975614 2595839.95067541 2032489.327934167 1.0 1.126483012404803 0.8820130456102171 21.13594444687763 -6.766090678740592 1.5893535349673518 1.072910375953115 0.880835156352941 0.7153736634776297 0.05325677104375109 0.27281696590434923 1.3594139142768467 0.02642146291571384 0.06312394912130613 1.7135994782652928e-07 6.766090678740592 -0.19207521960017393 LFPGSPAIYK(ub)LK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFPGSPAIYKLK 12 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;C9J6W1;Q7Z3J3-2;C9J1W9;C9JF75;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RGPD5;RGPD6;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 1 19971800.0 6574400.0 5354500.0 8042900.0 True False 8510690.400798503 5056517.368016214 6579174.727123015 1.0 0.5941371533785078 0.7730482977627448 23.020844739708625 -10.049577969668562 4.788033726224159 1.0000077454696337 0.6835927256054218 0.806583877996508 0.0730401688627103 101176901.2454749 4.264461534017653 9932.231693744883 0.025003592552827344 8.921174417627103e-11 10.049577969668562 -0.31641501986421183 LFPLFVLALLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFPLFVLALLK 11 0 O95486 O95486 SEC24A Protein transport protein Sec24A 0 401330000.0 139250000.0 141880000.0 120200000.0 False True 211252430.53862908 116560405.48650025 96442417.31446841 1.0 0.55175888480576 0.45652690039385463 27.654392699338004 -13.999999999995866 0.21770968953804898 3.6780393354411687 0.4044555777857324 0.9994957040520691 0.005321307130081787 12.938305936194013 0.14783178357216845 14.87856006896639 0.05351128781091213 1.000000000009518e-14 13.999999999995866 -3.2735837576554365 LFPLFVLALLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFPLFVLALLK 11 0 O95486 O95486 SEC24A Protein transport protein Sec24A 0 277110000.0 139250000.0 72224000.0 65636000.0 False True 180261870.02786478 68204670.91000152 53690921.48223234 1.0 0.3783643812163852 0.29784957558652214 27.425519021430453 -13.999999999999998 0.2881365811969957 6.300780363183729 0.27549416269421373 0.9996232937364604 0.006089468035129305 15.855853629732977 0.17018500451082255 49.76594213547412 0.030666497426232033 1.0000000000000041e-14 13.999999999999998 -6.025286200489515 LFPLIQAMHPTLAGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LFPLIQAMHPTLAGK 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAS6;H0YB75 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 42078600.0 13249200.0 17325600.0 11503800.0 False True 17369829.50543533 14740688.014659835 10313497.1282416 1.0 0.8486374612973151 0.5937592608502187 24.050080257472846 -6.963264390875561 0.38668466018423325 1.0162436624429125 0.4170434687486717 0.9998727757567767 0.0018907774431433642 0.0785549624448342 0.016967972182606036 0.003297736483955276 0.021470734105763518 1.0882673735076756e-07 6.963264390875561 -0.5992001936942408 LFPLIQAMHPTLAGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LFPLIQAMHPTLAGK 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAS6;H0YB75 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 66351600.0 32561600.0 14621900.0 19168100.0 False True 31527949.83131868 20460500.922201186 14147399.579326032 1.0 0.6489638886026294 0.44872564359616357 24.91012802312099 -10.073330009486645 0.11514608817462346 1.7817499927552165 7.111542197740951e-12 0.9998840025030314 0.00245394568313567 1.695320829381318 0.0547455067395397 0.634795811415453 0.2476212140032464 8.446367829360333e-11 10.073330009486645 -1.7817499927481049 LFPLIQAMHPTLAGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFPLIQAMHPTLAGK 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAS6;H0YB75 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 21355600.0 5213200.0 11519000.0 4623400.0 False True 7908805.535971135 9463344.451642213 3709582.963491797 1.0 1.1965579895220162 0.4690446549254155 22.91502839076622 -6.834768006271897 1.3065259764410593 1.104731320410677 0.44749837215920896 0.9150675003371909 0.08955302561238762 0.17500102161849918 0.5825347057228206 0.053789186022707366 0.12379591248901871 1.462958456665462e-07 6.834768006271897 -0.657232948251468 down LFPLIQAMHPTLAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LFPLIQAMHPTLAGK 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAS6;H0YB75 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 61008100.0 13249200.0 18378300.0 29380600.0 False True 18147787.286167193 17566285.937089104 22441507.392450865 1.0 0.9679574517869004 1.2365974451087203 24.113290318995737 -6.877119952223002 1.0956969025093304 0.9808034970803781 1.2546176490902845 0.9712888840003835 0.020299663297681424 0.1302136733297304 0.2879408528871804 0.014306204761359752 0.03435774286212437 1.3270278817408083e-07 6.877119952223002 0.27381415200990644 LFPLIQAMHPTLAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFPLIQAMHPTLAGK 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAS6;H0YB75 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 37349000.0 21720000.0 6264500.0 9364500.0 False True 18061142.3591478 6230751.8950941 11322573.653444111 1.0 0.3449810522056089 0.6269024089558396 24.106385809729993 -10.42492850104832 6.056372832835031 1.0001691083089281 0.4859417305808382 0.8159429999053651 0.11509391193853497 0.00026288875563579766 2.4962279107951e-05 0.11147523586130328 0.03714640034898402 3.758992844035489e-11 10.42492850104832 -0.5142273777280899 LFPLIQAMHPTLAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFPLIQAMHPTLAGK 15 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAS6;H0YB75 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 12892900.0 5213200.0 7679700.0 0.0 False True 6748590.16753511 7252317.944001148 0.0 1.0 1.074641927270866 0.0 22.68615471285867 -6.974100268046126 1.1628614168735085 1.0486083204922862 1.7394682504059717e-21 0.9784800466097558 0.07187356287267734 0.09884521562534677 0.26381819991331373 0.05177180401480298 0.09657258817227508 1.0614504657788603e-07 6.974100268046126 -1.0486083204922862 down LFPLYVLALLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFPLYVLALLK 11 0 O95487-2;O95487;O95487-3 O95487-2 SEC24B Protein transport protein Sec24B 0 274442000.0 89915000.0 90244000.0 94283000.0 False True 136407628.6670077 74139253.12040973 75647923.72429316 1.0 0.5435125135222107 0.5545725298763278 27.023349089181668 -10.017719253342294 5.425545378741835 1.000002112160049 0.5490425216986774 0.9995490727860988 0.004515232771149546 1.153586687007445e-07 2.0892759525142024e-08 0.004371875783495594 0.001457285110275072 9.600210299090301e-11 10.017719253342294 -0.4509595904613717 LFPLYVLALLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFPLYVLALLK 11 0 O95487-2;O95487;O95487-3 O95487-2 SEC24B Protein transport protein Sec24B 0 241977000.0 89915000.0 75050000.0 77012000.0 False True 116396739.98962624 70873401.52574794 62996606.20984945 1.0 0.6088950732818159 0.5412231151444961 26.794475411274117 -13.999999999999998 0.24679367366149538 3.676610624773717 0.5131711730094076 0.9995367661545975 0.004352246652849804 13.87313982155383 0.1572060201954055 18.37348356125462 0.03179682935131387 1.0000000000000041e-14 13.999999999999998 -3.1634394517643094 LFQDTK(ub)GDSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFQDTKGDSSR 11 1 Q13315;E9PIN0 Q13315 ATM Serine-protein kinase ATM 1 2934690.0 615120.0 742670.0 1576900.0 True False 806428.2768305534 631866.5309049862 1413737.5146928986 1.0 0.7835371713258437 1.7530852467738465 19.621186701230968 -6.848119710196029 1.2442618477579381 0.884653778076595 1.7904321560336265 0.9375044932488399 0.10387978127278301 0.1595399611355713 0.476275857746618 0.06536173232818093 0.15106865540352465 1.4186664224446486e-07 6.848119710196029 0.9057783779570315 LFQDTK(ub)GDSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFQDTKGDSSR 11 1 Q13315;E9PIN0 Q13315 ATM Serine-protein kinase ATM 1 2305990.0 615120.0 534270.0 1156600.0 True False 842546.4869929621 510664.1848053734 883434.9009247163 1.0 0.6060961533741925 1.048529564318385 19.68439676275386 -6.6719091936378465 1.9309188970739488 0.7489772652597292 1.046742837550125 0.2873464438569229 0.16725028037801537 0.45677930366409 3.285267722177521 0.06969136820537533 0.18571429851355775 2.1285840637701694e-07 6.6719091936378465 0.2977655722903959 LFQECCPHSTDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFQECCPHSTDR 12 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 20789620.0 766120.0 10820000.0 9203500.0 False True 1004390.7391166341 9205698.176029664 8251210.1062058965 1.0 9.165455054002305 8.215139571540524 19.93788920088364 -9.994239452342617 7.396418063549351 0.9999997201549692 8.690297312771415 0.988676908843678 0.3879646711163689 1.7922482230955871e-06 2.4217341168218524e-07 0.375645177528924 0.12521505917921036 1.0133525102536513e-10 9.994239452342617 7.690297592616446 LFQECCPHSTDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFQECCPHSTDR 12 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 20908420.0 766120.0 11238000.0 8904300.0 False True 1049375.267614528 10741468.000903623 6801287.729814934 1.0 10.236059808538709 6.481273134324796 20.00109926240653 -10.087797353938715 7.060165022523209 0.9999973300899654 8.358666471431754 0.8366316726158334 1.5328852408043296 6.442141610306777e-05 8.320107168097113e-06 1.4842102802727268 0.4947365841068586 8.169634856043747e-11 10.087797353938715 7.358669141341788 LFQEKMADLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFQEKMADLPR 11 1 Q06520 Q06520 SULT2A1 Bile salt sulfotransferase 0 61713000.0 12842000.0 11917000.0 36954000.0 False True 16835986.362104904 10139030.052102173 33130354.567798406 1.0 0.6022237030865918 1.967829734191844 24.005044910356695 -6.828752245712282 1.3334815903941488 0.7872665834456465 2.0036492158613073 0.9033599702471363 0.17827418956506053 0.18235191850844415 0.6345948021326172 0.10498265171026931 0.24160887709151865 1.4833640664220318e-07 6.828752245712282 1.2163826324156608 LFQEKMADLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFQEKMADLPR 11 1 Q06520 Q06520 SULT2A1 Bile salt sulfotransferase 0 72935000.0 12288000.0 14904000.0 45743000.0 False True 11897924.166111134 20855244.92333325 33761536.03941506 1.0 1.752847356577987 2.837598859099982 23.504206552325147 -6.96591702307378 0.34194835097501647 0.8849671802989809 3.7416350580293316 0.999930819806364 0.0062735646111399595 0.07765113206670472 0.013770291861885229 0.01522329988941289 0.09375727862909222 1.0816405913586188e-07 6.96591702307378 2.8566678777303505 LFQEKMADLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFQEKMADLPR 11 1 Q06520 Q06520 SULT2A1 Bile salt sulfotransferase 0 67066000.0 12842000.0 11807000.0 42417000.0 False True 17590034.442000944 11285327.699472237 32398978.205536637 1.0 0.6415750768813436 1.8418939606039288 24.068254971879586 -6.826691471137096 1.3427639212876656 0.8080004185522051 1.8720319085681978 0.8990563134384071 0.15984425225960724 0.18493938241343458 0.6533127634966323 0.09349928244266363 0.21520559484411425 1.4904195165330616e-07 6.826691471137096 1.0640314900159926 LFQEKMADLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFQEKMADLPR 11 1 Q06520 Q06520 SULT2A1 Bile salt sulfotransferase 0 75801000.0 12288000.0 12512000.0 51001000.0 False True 10218016.45070018 12444595.372562457 61665073.29801945 1.0 1.2179071576763514 6.0349358014386345 23.284611827759424 -6.9163617762198 0.8512643338659527 0.8791514551474633 6.750266369206199 0.9931093520807545 0.19290126370526572 0.10036022492701527 0.11705334232848107 0.16307802203308805 0.47273228396651334 1.2123784935232682e-07 6.9163617762198 5.871114914058736 up LFQEKMADLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFQEKMADLPR 11 1 Q06520 Q06520 SULT2A1 Bile salt sulfotransferase 0 46887000.0 12786000.0 21494000.0 12607000.0 False True 16551729.049739886 20297840.005255494 10312655.358743731 1.0 1.2263274697318995 0.6230560763623542 23.980478597932194 -6.80508220660892 1.4350670892355 1.124081560288425 0.6136443208313159 0.8466100940008598 0.09745431882249841 0.21358148788929585 0.8677694657635622 0.053411295625160886 0.1238512243105368 1.5664545314488796e-07 6.80508220660892 -0.5104372394571092 LFQEQQNEGHGEALLFEGIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFQEQQNEGHGEALLFEGIKK 21 1 Q9UM07 Q9UM07 PADI4 Protein-arginine deiminase type-4 1 15736400.0 5357200.0 5245600.0 5133600.0 True False 5187138.618383018 7340195.435442617 3788956.155301159 1.0 1.4150760130892297 0.7304520727233402 22.306507493369384 -6.742591806194843 1.6772112530427474 1.246230562979126 0.7298222869539959 0.6164654052165686 0.17439133646486543 0.3131743262001613 1.730751875503969 0.08222335384751604 0.2011972222427375 1.8088734892178412e-07 6.742591806194843 -0.5164082760251301 LFQEQQNEGHGEALLFEGIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFQEQQNEGHGEALLFEGIKK 21 1 Q9UM07 Q9UM07 PADI4 Protein-arginine deiminase type-4 1 17829300.0 5357200.0 6683100.0 5789000.0 True False 4454749.164200112 6647096.813808517 6999453.134688227 1.0 1.492137170646298 1.5712339520568805 22.08691276880366 -11.749557489134446 0.30428189418665474 3.451816881916984e-19 1.5919443354284126 0.9994388284557741 0.005986472103743948 4.526310850085579 0.16427546428787695 2.9355439512733192 0.028031211996268027 1.7800922559940084e-12 11.749557489134446 1.5919443354284126 LFQFLQAEPHNSLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFQFLQAEPHNSLGK 15 0 Q6P2E9;Q6P2E9-2;I3L0V0;I3L3M2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 0 12597300.0 3317000.0 3195800.0 6084500.0 False True 4348619.121873691 2718999.0971308313 5454934.306645284 1.0 0.625255746923013 1.2544060893277118 22.05212592378098 -6.745393664629245 1.6672732702240618 0.7784288631298834 1.255202167788137 0.6287709777616239 0.15744607385136292 0.3081417371785601 1.6838561555236327 0.07465196705057267 0.18209297967616822 1.7972410740244313e-07 6.745393664629245 0.47677330465825374 LFQFLQAEPHNSLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFQFLQAEPHNSLGK 15 0 Q6P2E9;Q6P2E9-2;I3L0V0;I3L3M2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 0 14676000.0 3317000.0 4645300.0 6713700.0 False True 4543384.538554517 4440055.286047134 5128062.332991749 1.0 0.9772572073460775 1.128687719358936 22.115335985303872 -6.868650212549456 1.141150476187582 0.9872355919134601 1.1373339905721627 0.9633206128449158 0.012769338189711833 0.13815892508654062 0.3370906186635294 0.00869083895420296 0.020530000863562273 1.3531619818755188e-07 6.868650212549456 0.15009839865870256 LFQGQLVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFQGQLVLR 9 0 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 0 8505300.0 2170600.0 3717900.0 2616800.0 False True 2809884.4889226784 3510995.596703237 2140569.250635409 1.0 1.249515989196185 0.7617997320082407 21.42207939347724 -6.767665870460973 1.5835900471263546 1.1435469764824335 0.7593097658579531 0.721440780998009 0.10509676185868622 0.2702414729204699 1.337134736609596 0.052324545254727496 0.12481255263149449 1.7073954885023776e-07 6.767665870460973 -0.38423721062448046 LFQLQTLGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFQLQTLGLK 10 0 H0Y9C1;H0Y9Z5;Q96LI5;D6RGK9;Q9ULM6 H0Y9C1 CNOT6L;CNOT6 CCR4-NOT transcription complex subunit 6-like;CCR4-NOT transcription complex subunit 6 0 3830190.0 1090600.0 2098200.0 641390.0 False True 1429787.1613854251 1785156.7387195397 575025.1154473195 1.0 1.2485471872539204 0.4021753243959301 20.447368972224872 -6.828075409626939 1.3364758849338851 1.1329939115725818 0.38028024400189586 0.9019749768297947 0.1112099720241191 0.1831962031053693 0.640628384354007 0.06534685498870069 0.15039900646852794 1.4856776511558284e-07 6.828075409626939 -0.7527136675706859 down LFQLQTLGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFQLQTLGLK 10 0 H0Y9C1;H0Y9Z5;Q96LI5;D6RGK9;Q9ULM6 H0Y9C1 CNOT6L;CNOT6 CCR4-NOT transcription complex subunit 6-like;CCR4-NOT transcription complex subunit 6 0 5216900.0 1090600.0 1891700.0 2234600.0 False True 1493824.2923568178 1808118.4389846406 1706833.503031617 1.0 1.2103956591387055 1.1425932164610424 20.510579033747764 -10.079417010181018 4.284520381592998 0.9999810188893957 1.1764944377763478 0.9003450447784017 0.027680231408320266 19228566.789897688 0.16191751686726175 3806.5857470554197 0.009475679447836838 8.328810669555032e-11 10.079417010181018 0.17651341888695204 LFQQILSGVDYCHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFQQILSGVDYCHR 14 0 Q13131-2;Q13131;Q96E92 Q13131-2 PRKAA1 5-AMP-activated protein kinase catalytic subunit alpha-1 0 6089700.0 1920900.0 1650600.0 2518200.0 False True 2518318.5020220587 1404336.9139884068 2257640.8202800807 1.0 0.5576486504232123 0.8964874055713487 21.264029327452196 -10.384444603303251 6.092278344740881 1.0000485198667861 0.7270680279972807 0.46383291048129127 0.13833034253213045 9.11791427144023e-05 9.212752344257734e-06 0.1339615250853298 0.044645926075175674 4.126248663758323e-11 10.384444603303251 -0.27298049186950546 LFQQILSGVDYCHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFQQILSGVDYCHR 14 0 Q13131-2;Q13131;Q96E92 Q13131-2 PRKAA1 5-AMP-activated protein kinase catalytic subunit alpha-1 0 8000400.0 1920900.0 1973000.0 4106500.0 False True 2631108.640370626 1885826.3361614954 3136629.2760222605 1.0 0.7167421014952283 1.1921321787687282 21.327239388975087 -6.74525743063266 1.6670470577757337 0.832505735523639 1.1927679853516233 0.6285274284338475 0.11900940895148991 0.30835692951000643 1.6843990495411998 0.056427964686534875 0.13769967407335182 1.7978049396763633e-07 6.74525743063266 0.36026224982798427 LFQVEYAIEAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFQVEYAIEAIK 12 0 P28066 P28066 PSMA5 Proteasome subunit alpha type-5 0 6353000.0 2277600.0 2523600.0 1551800.0 False True 2985955.6563097774 2147088.716915755 1391234.6219166985 1.0 0.7190624925653637 0.4659260826519003 21.509761309847864 -6.9723626482174215 0.19360773623844552 1.1636800975232275 0.014366993465608682 0.9999954233795522 0.00046661747241463964 0.07554326066447842 0.006202995456348264 0.008667688758592109 0.027324651882035245 1.065705854950169e-07 6.9723626482174215 -1.1493131040576188 down LFQVEYAIEAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFQVEYAIEAIK 12 0 P28066 P28066 PSMA5 Proteasome subunit alpha type-5 0 22166200.0 11263000.0 5561000.0 5342200.0 False True 10905462.230054509 7781536.300231887 3942917.557435306 1.0 0.7135448398314239 0.3615543728691267 23.378547584385043 -6.970360852974728 0.295032163080969 1.064844192925773 3.105494619821063e-12 0.9999666835605604 0.0015070779930423208 0.07656893029532628 0.010920638746530938 0.005983727914357929 0.03163908830951375 1.0706293553254949e-07 6.970360852974728 -1.0648441929226675 down LFQVEYAIEAIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFQVEYAIEAIK 12 0 P28066 P28066 PSMA5 Proteasome subunit alpha type-5 0 93487000.0 19941000.0 47436000.0 26110000.0 False True 30251954.88237554 38970675.18084033 20949347.055580437 1.0 1.2882035337010311 0.6924956465469707 24.85052503661473 -6.775124573127155 1.554561277182828 1.1642205629067617 0.6884532807682484 0.7498633069954097 0.12165288046737521 0.25822508921187837 1.2321529735487962 0.0616546672764117 0.14610152909517216 1.6783225386564452e-07 6.775124573127155 -0.47576728213851327 LFQVEYAIEAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFQVEYAIEAIK 12 0 P28066 P28066 PSMA5 Proteasome subunit alpha type-5 0 7937600.0 2277600.0 2586700.0 3073300.0 False True 3119690.26982568 2472411.0409269794 2347449.8366003158 1.0 0.7925181114422397 0.7524624669651853 21.572971371370755 -13.999999999999998 0.2312617871415855 2.3174664690226545 0.733219419283008 0.9995115403408724 0.0023977133596839086 13.330957989010667 0.15225817793239588 8.07030756615671 0.020630571503172487 1.0000000000000041e-14 13.999999999999998 -1.5842470497396466 LFQVEYAIEAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFQVEYAIEAIK 12 0 P28066 P28066 PSMA5 Proteasome subunit alpha type-5 0 19107000.0 11263000.0 4248800.0 3595200.0 False True 9365683.535500996 4225910.871079234 4346939.697673369 1.0 0.45121222119675 0.4641348045976699 23.15895285981932 -10.000505952200763 5.474195871725253 1.000001831616708 0.4576735128965055 0.9995743487212387 0.005275622584279822 1.1793371946982537e-07 2.153144990706842e-08 0.005108116839000344 0.0017026998671235518 9.988356803514701e-11 10.000505952200763 -0.5423283187202026 LFQVEYAIEAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFQVEYAIEAIK 12 0 P28066 P28066 PSMA5 Proteasome subunit alpha type-5 0 67294000.0 19941000.0 28055000.0 19298000.0 False True 25814017.59587536 26493714.587672994 15785962.014201349 1.0 1.0263305387963413 0.6115267395154979 24.62165135870718 -6.891761332655164 1.0118723828541274 1.0213558481687912 0.5745893726763341 0.9820030292268717 0.025440616222059436 0.1177269742663699 0.2135774472985799 0.019110838930360998 0.04795742387181577 1.2830354834982448e-07 6.891761332655164 -0.44676647549245707 LFRPWLNMDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFRPWLNMDR 10 1 B3KSI3;M0QZ10;M0QXF9;O15382;M0QZP4;O15382-2;M0R2K7 B3KSI3 BCAT2 Branched-chain-amino-acid aminotransferase;Branched-chain-amino-acid aminotransferase, mitochondrial 0 6740900.0 2589000.0 2233800.0 1918100.0 False True 2152868.2121470333 2221766.0760254166 2319165.8417076324 1.0 1.0320028246455792 1.0772446862387142 21.037828576938377 -6.9662237009310255 0.33639444857442824 0.9948833221486043 1.1158595157602589 0.9999361552957818 0.0002531386074277143 0.07754820610168517 0.013409399484949784 0.000645943850767272 0.003926412558876711 1.080877058457354e-07 6.9662237009310255 0.12097619361165457 LFSFTPAWNWTCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFSFTPAWNWTCK 13 0 Q9ULZ3-3;Q9ULZ3-2;Q9ULZ3 Q9ULZ3-3 PYCARD Apoptosis-associated speck-like protein containing a CARD 0 11744100.0 3146100.0 6290100.0 2307900.0 False True 4124567.5668757395 5351641.598617764 2069100.646940035 1.0 1.2975036805304425 0.5016527462313652 21.975811439754874 -6.805456968672977 1.4334814680333197 1.163028290860781 0.4891222271560952 0.8476506603877543 0.12815571540290435 0.2130602598618899 0.8636793206644746 0.07031346568103952 0.16301428492542844 1.565103387138553e-07 6.805456968672977 -0.6739060637046858 LFSFTPAWNWTCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFSFTPAWNWTCK 13 0 Q9ULZ3-3;Q9ULZ3-2;Q9ULZ3 Q9ULZ3-3 PYCARD Apoptosis-associated speck-like protein containing a CARD 0 14381800.0 7576800.0 3505600.0 3299400.0 False True 7336278.631330632 4905404.361462494 2435188.1601216802 1.0 0.6686502255398616 0.33193779605396384 22.80661700275077 -7.279021117414635 0.27601086498966204 1.0935878084508843 9.360562564977963e-13 0.999916919209616 0.0024859653975188825 0.10203926700946277 0.017650268221917217 0.013511834625615695 0.04631145267294228 5.259916896101523e-08 7.279021117414635 -1.0935878084499482 down LFSFTPAWNWTCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFSFTPAWNWTCK 13 0 Q9ULZ3-3;Q9ULZ3-2;Q9ULZ3 Q9ULZ3-3 PYCARD Apoptosis-associated speck-like protein containing a CARD 0 19127600.0 3146100.0 5384500.0 10597000.0 False True 4309298.190155675 5146594.985839612 8094206.852065714 1.0 1.1943000365109775 1.8783120812006997 22.039021501277766 -6.947810735437482 0.5823817946801808 0.9918945773328451 2.1146886410875383 0.9990180992366612 0.011803686030606567 0.08437691518903753 0.03969357549786818 0.01233554195681385 0.05717702619872854 1.1276887933563569e-07 6.947810735437482 1.1227940637546932 LFSFTPAWNWTCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFSFTPAWNWTCK 13 0 Q9ULZ3-3;Q9ULZ3-2;Q9ULZ3 Q9ULZ3-3 PYCARD Apoptosis-associated speck-like protein containing a CARD 0 15075500.0 7576800.0 3451600.0 4047100.0 False True 6300444.909152433 3433005.54571104 4893329.898323836 1.0 0.5448830352796251 0.7766641830667337 22.587022278185046 -10.064402975992275 4.856836952954004 1.0000096927583537 0.6607736091694025 0.7406654824007848 0.09462425735886945 131269031.85219885 0.6239316578370039 14229.189446319217 0.03239240014967378 8.621781729976958e-11 10.064402975992275 -0.3392360835889512 LFSLPAQPLWNNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFSLPAQPLWNNR 13 0 O60216 O60216 RAD21 Double-strand-break repair protein rad21 homolog 0 10305000.0 2101800.0 4082100.0 4121100.0 False True 2878892.2590093086 3901739.324300473 3147781.056718696 1.0 1.3552918877357185 1.093400090561888 21.457082367151706 -10.415607417343006 4.832022647057444 0.9996633954945152 1.2243459891488506 0.49454974528509776 0.10691687848292017 0.0003882773263763901 4.6958697702831016e-05 0.10367568210879027 0.03450727414937489 3.8405425638279084e-11 10.415607417343006 0.2246825936543354 LFSLTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFSLTLK 7 0 Q6VY07;Q6VY07-2;E9PPK2 Q6VY07 PACS1 Phosphofurin acidic cluster sorting protein 1 0 9432200.0 2085300.0 3316400.0 4030500.0 False True 2856291.7631135774 3169870.4821317634 3078578.910753129 1.0 1.1097852548075695 1.077823684019325 21.445711923935622 -10.027542225853935 4.246432625018564 0.99999321042691 1.0938044694409554 0.9199036263876218 0.013048256729270985 6816630.495870756 0.007233793478223401 464.0443027444607 0.004775172995369736 9.385507782370747e-11 10.027542225853935 0.09381125901404541 LFSLTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFSLTLK 7 0 Q6VY07;Q6VY07-2;E9PPK2 Q6VY07 PACS1 Phosphofurin acidic cluster sorting protein 1 0 5931400.0 2868000.0 1387100.0 1676300.0 False True 2384869.0739427167 1379627.4169822065 2026806.5796645163 1.0 0.578491889578398 0.8498607331570434 21.18547863574017 -10.665996678894292 6.345942736935505 1.0021703624645273 0.714176311367721 0.5966376000663103 0.11078586647613742 0.003424234413832735 0.00018022601196668233 0.10797392437959202 0.03575598465476992 2.1577609097645163e-11 10.665996678894292 -0.2879940510968063 LFSLTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFSLTLK 7 0 Q6VY07;Q6VY07-2;E9PPK2 Q6VY07 PACS1 Phosphofurin acidic cluster sorting protein 1 0 20380100.0 5768000.0 8119400.0 6492700.0 False True 7466789.70427809 7667548.252473785 5311095.220727805 1.0 1.02688686251344 0.7112956747241479 22.832056668669157 -6.8861835056856355 1.0446645381747308 1.0185406663260772 0.6860948157505922 0.9783421519143325 0.021023573831847987 0.12229563484215088 0.2403579267925871 0.01540524386075561 0.03791507707151346 1.299620323735557e-07 6.8861835056856355 -0.33244585057548504 LFSQDECAK(ub)IEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFSQDECAKIEAR 13 1 Q6P6C2;Q6P6C2-3;Q6P6C2-1 Q6P6C2 ALKBH5 RNA demethylase ALKBH5 1 14475800.0 0.0 2629800.0 11846000.0 True False 0.0 2483449.3182200096 9690149.550224343 0.0 LFTAESLIGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFTAESLIGLK 11 0 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 0 18728000.0 4928700.0 6263000.0 7536300.0 False True 6461573.429598691 5328584.8129827855 6756515.969294245 1.0 0.8246574725242622 1.0456456222171064 22.623454081407527 -6.695303392766282 1.8480019169804602 0.8906206788893632 1.044925702581317 0.39520262427644703 0.07407979661151332 0.40534401066561265 2.6879364943964186 0.032023772879999746 0.08282578667928625 2.0169568502362648e-07 6.695303392766282 0.15430502369195376 LFTAESLIGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFTAESLIGLK 11 0 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 0 19759600.0 7396800.0 4109800.0 8253000.0 False True 7161992.632803623 5750864.572323866 6091291.715307087 1.0 0.8029699089585131 0.8505023710032217 22.77192960395257 -10.817161920366035 7.10815602934061 1.0086909326476803 0.8267361399810121 0.9465707554416013 0.01940504637129075 0.0027513445649955583 7.077079684019501e-05 0.01934218071111526 0.006262951785699312 1.523484638860343e-11 10.817161920366035 -0.18195479266666814 LFTAESLIGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFTAESLIGLK 11 0 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 0 23828200.0 4928700.0 8164500.0 10735000.0 False True 6750973.5831093285 7803765.393608986 8199614.0942649385 1.0 1.1559466642165068 1.2145824588589789 22.686664142930418 -13.999999994356086 0.13572749141687324 0.2573924819249497 1.2910230398058993 0.9996204998627423 0.0017640863459400383 11.932267436413257 0.11509722068307872 2.353142838763946 0.06816082011918936 1.0000000129955918e-14 13.999999994356086 1.0336305578809495 LFTAESLIGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFTAESLIGLK 11 0 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 0 13674200.0 7396800.0 3415800.0 2861600.0 False True 6150766.933800388 3397398.4074167837 3459947.329456526 1.0 0.5523536241874191 0.5625229124587754 22.552334879386848 -10.003116790579512 5.12081026743329 1.0000034763545842 0.5574382683202294 0.9996041564613979 0.0041515945619998215 1188632.0366799296 2321903.3386761043 30.194900384454208 0.001421201138822023 9.928490153144238e-11 10.003116790579512 -0.44256520803435484 LFTAESLIGLK(ub)NPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFTAESLIGLKNPEK 15 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 6288800.0 1733100.0 2355500.0 2200200.0 True False 2272110.883364275 2004068.5816670877 1972544.409808684 1.0 0.8820293922890322 0.8681549937774039 21.11560181216688 -13.99999999930078 0.30201663457749445 2.0886594304136614 0.8648119825400897 0.9996543163936115 0.001099808036693645 16.721034387750393 0.17459265998851295 11.388475490882296 0.004971056417565496 1.0000000016100141e-14 13.99999999930078 -1.2238474478735717 LFTAESLIGLK(ub)NPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFTAESLIGLKNPEK 15 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 9562900.0 2505900.0 2887800.0 4169200.0 True False 2426351.57616031 4040913.5996780586 3077161.446681005 1.0 1.6654278956855815 1.2682257084732125 21.210357180142672 -10.199297084683149 4.650237987447876 0.999911759762477 1.4668268020826183 0.6481022494544502 0.1621571139092525 0.0001483856179880226 2.5549722459243687e-05 0.15703748511514573 0.052335983468369915 6.319793899102114e-11 10.199297084683149 0.46691504232014125 LFTAESLIGLK(ub)NPEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFTAESLIGLKNPEK 15 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 19830000.0 3908000.0 0.0 15922000.0 True False 5928721.713069746 0.0 12775009.721139489 1.0 0.0 2.154766295233126 22.49928964930427 -6.78050310492549 1.5338915023964694 0.4341506523801105 2.17211844766992 0.7691963682797269 0.4229791464664929 0.24977837931558003 1.1608194237824612 0.21718384816810501 0.5122516386841871 1.657665485567243e-07 6.78050310492549 1.7379677952898094 LFTAESLIGLK(ub)NPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFTAESLIGLKNPEK 15 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 6425900.0 1733100.0 1518100.0 3174700.0 True False 2373873.9052664572 1451025.322314629 2424901.2449988713 1.0 0.6112478506526898 1.0214953876106097 21.17881187368977 -11.020116686328715 12.704743696169983 1.3307631724241296 0.8163716191316492 0.21081641531227124 0.16748285563008122 0.04750618556844435 7.522132906101063e-05 0.004909663397455079 0.054054859219213804 9.547360328883354e-12 11.020116686328715 -0.5143915532924803 LFTAESLIGLK(ub)NPEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFTAESLIGLKNPEK 15 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 9055700.0 2505900.0 2646100.0 3903700.0 True False 2083766.8801928372 2631844.9340902716 4719945.621330532 1.0 1.2630227301850165 2.2651025247573453 20.99076245557695 -6.945994405818211 0.6012136737315691 0.9887424616014117 2.590786702716209 0.9988482728028034 0.018497812455080552 0.08513517744435943 0.04293427648160043 0.018962430781590395 0.08424570070027723 1.1324149498687152e-07 6.945994405818211 1.6020442411147973 up LFTAESLIGLK(ub)NPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFTAESLIGLKNPEK 15 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 18948300.0 3908000.0 5632700.0 9407600.0 True False 5058983.038196735 5319235.2934587635 7695513.330127506 1.0 1.0514435911915598 1.5211581600539537 22.27041597139672 -6.92772183993286 0.7652495945287487 0.9922216018186344 1.6122260246112752 0.996071579530748 0.014697363034772822 0.09383749294028965 0.08359895005996398 0.013212993784449054 0.04304550452316236 1.1810768580887148e-07 6.92772183993286 0.6200044227926408 LFTAHNNMTNYATVWASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFTAHNNMTNYATVWASK 18 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 55441000.0 21615000.0 22590000.0 11236000.0 False True 28337474.319957793 19219660.055130314 10073406.503322605 1.0 0.6782418164061327 0.3554800399493616 24.756207842776227 -7.2163601893873475 0.26084955387684294 1.1027982402811607 4.786565848790129e-11 0.9999547017774496 0.0017709210267676891 0.09280861432828592 0.013910940551285288 0.011654048372880454 0.04034760325008304 6.07630843445824e-08 7.2163601893873475 -1.102798240233295 down LFTAHNNMTNYATVWASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFTAHNNMTNYATVWASK 18 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 54556000.0 13615000.0 12752000.0 28189000.0 False True 13182799.277474208 17843940.1008015 20805455.248126946 1.0 1.353577470552245 1.5782274166669419 23.65215341353515 -9.225140130777294 0.08499366162622403 6.7778499887753734e-18 2.4158578644292623 0.9999765978038425 0.0011513701232862099 0.6887212676345049 0.030394868521944382 0.5008968170159023 0.3463615956426285 5.954699763759269e-10 9.225140130777294 2.4158578644292623 LFTAHNNMTNYATVWASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFTAHNNMTNYATVWASK 18 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 71353000.0 21615000.0 22184000.0 27554000.0 False True 29606649.62341153 21203837.527322154 21046312.692443047 1.0 0.7161849718569699 0.710864382162331 24.81941790429912 LFTAHNNMTNYATVWASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFTAHNNMTNYATVWASK 18 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 41188000.0 13615000.0 14208000.0 13365000.0 False True 11321475.746767819 14131458.683932802 16159559.707222013 1.0 1.2481993513934972 1.4273368656763163 23.432558688969426 -6.974664498320684 0.09469557514527291 0.5160882309115512 2.1639777742613897 0.9999997962337533 7.888292612305979e-05 0.07481607984782307 0.0027702800514273975 0.017367343458009495 0.030565691081418492 1.0600723372564557e-07 6.974664498320684 1.6478895433498386 LFTAYLQLYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFTAYLQLYR 10 0 B9ZVN9;O95602 B9ZVN9 POLR1A DNA-directed RNA polymerase;DNA-directed RNA polymerase I subunit RPA1 0 27919700.0 11965000.0 8214700.0 7740000.0 False True 18151779.75866926 6748722.603255948 6210185.607437482 1.0 0.37179398896313565 0.3421254383869167 24.113607673761745 -13.586844648132622 0.43911337729341915 9.99999999999995 0.34181593313434633 0.9998808864774147 0.0033109925637190207 22.832493324511344 0.22340566353821542 195.91925112067466 0.00687116776590377 2.5891389127186485e-14 13.586844648132622 -9.658184066865603 LFTAYLQLYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFTAYLQLYR 10 0 B9ZVN9;O95602 B9ZVN9 POLR1A DNA-directed RNA polymerase;DNA-directed RNA polymerase I subunit RPA1 0 28712800.0 11965000.0 8131200.0 8616600.0 False True 15488928.365410414 7678691.572100748 7048467.213782116 1.0 0.4957535725485476 0.45506487263009243 23.884733995854194 -13.999999999999998 0.35675018421582533 7.4656541676760755 0.4499355980582672 0.9997673561355114 0.0037803956162043694 21.35042765168707 0.19277460272011604 104.944469511161 0.011867430905684088 1.0000000000000041e-14 13.999999999999998 -7.015718569617809 LFTFLPLPEIDHIMQLHVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFTFLPLPEIDHIMQLHVK 19 0 Q9Y2Z4 Q9Y2Z4 YARS2 Tyrosine--tRNA ligase, mitochondrial 0 413750000.0 103070000.0 176160000.0 134520000.0 False True 156364725.42633036 144722871.65563783 107932063.03778951 1.0 0.9255468025863834 0.6902583862409595 27.220339848519732 -6.950276148069276 0.5558119408162878 1.0031474036788417 0.6014936770944918 0.9992227181954645 0.003680451667419422 0.083375209854954 0.03550612201905002 0.003965493863532591 0.019541502324689253 1.121305240673804e-07 6.950276148069276 -0.40165372658434995 LFTFLPLPEIDHIMQLHVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFTFLPLPEIDHIMQLHVK 19 0 Q9Y2Z4 Q9Y2Z4 YARS2 Tyrosine--tRNA ligase, mitochondrial 0 19900000.0 9407100.0 6833800.0 3659100.0 False True 12177676.391663363 6453493.022607001 2993181.34553654 1.0 0.5299445325238693 0.2457924853041441 23.53773554474444 -8.592597869867298 0.2319519467845846 1.2756754541486417 8.69822324050871e-21 0.9994672346933837 0.007178551552349617 0.2046061415634307 0.06347148854479016 0.15646905650542017 0.11733365974961991 2.555066042600619e-09 8.592597869867298 -1.2756754541486417 down LFTFQFNNLGNTDINYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFTFQFNNLGNTDINYIK 18 0 Q9Y4E8-2;Q9Y4E8-3;Q9Y4E8 Q9Y4E8-2 USP15 Ubiquitin carboxyl-terminal hydrolase 15 0 47362000.0 20630000.0 12795000.0 13937000.0 False True 26705941.67809583 12082947.002291057 11400609.005696155 1.0 0.45244414699675134 0.42689410256021476 24.67065742020218 -13.720050754808543 0.4396395635693446 9.999999999982975 0.42664628377037234 0.9998833444607346 0.0028551468189720566 25.87449606507606 0.22372098084242606 223.24952993879538 0.005910148569692967 1.905238044991371e-14 13.720050754808543 -9.573353716212603 LFTK(ub)VKPLLQVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFTKVKPLLQVSR 13 2 P35579;P35579-2 P35579 MYH9 Myosin-9 1 23881590.0 10279100.0 942790.0 12659700.0 True False 15594146.202869816 774541.7584481082 10157504.746056367 1.0 0.04966875059216567 0.6513665200975906 23.894501229901774 -10.15210120453132 6.863835319372471 1.0000009833989074 0.35051763685433796 0.6083836175650735 0.24564208577650964 3.6970035782983656e-06 4.5593580062473334e-07 0.2378422882772335 0.0792806422783396 7.045288720323917e-11 10.15210120453132 -0.6494833465445695 LFTK(ub)VKPLLQVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFTKVKPLLQVSR 13 2 P35579;P35579-2 P35579 MYH9 Myosin-9 1 15508500.0 10279100.0 3000400.0 2229000.0 True False 13306497.581353137 2833425.1024364256 1823344.8714713852 1.0 0.21293545390990065 0.1370266563627158 23.665627551994223 -13.999999999999998 0.3307364627954655 9.605837500584956 0.1236988936268616 0.9997163688018591 0.006570657731279833 18.88565585791577 0.18394087537302928 113.09744255373359 0.02425847692435048 1.0000000000000041e-14 13.999999999999998 -9.482138606958094 LFTLPLLHYLEVSGCGSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFTLPLLHYLEVSGCGSLR 19 0 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 0 933910000.0 310180000.0 240280000.0 383450000.0 False True 470565737.19548976 197400156.68379128 307660939.4278945 1.0 0.4194953883813777 0.6538107539692827 28.809821038059567 -10.272171818632732 5.634173033795841 1.0000367448413037 0.5366530711753285 0.8390664529922136 0.09565884743070716 4.415580208449632e-05 5.704134816397975e-06 0.0926286049350624 0.030873760251372746 5.343529131208565e-11 10.272171818632732 -0.4633836736659752 LFTLPLLHYLEVSGCGSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFTLPLLHYLEVSGCGSLR 19 0 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 0 780770000.0 310180000.0 182830000.0 287760000.0 False True 401534124.5618893 172655349.77951348 235390632.66693872 1.0 0.4299892318439843 0.5862282139127567 28.580947360152017 -10.584668375407322 9.787958400355599 1.0000423272893715 0.5081087228784864 0.929656445315566 0.06378429733339049 5.8920351309112557e-05 2.5001788961870646e-06 0.06176413797050654 0.020586293443480286 2.602145787237734e-11 10.584668375407322 -0.4919336044108851 LFTLTALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFTLTALR 8 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQQ5;A0A1B0GTT3 P47897 QARS Glutamine--tRNA ligase 0 20822000.0 6201900.0 10549000.0 4071100.0 False True 8130750.95928503 8975130.319679944 3649861.624748724 1.0 1.1038501074037526 0.4488960051815031 22.95495717564699 -6.866324203418938 1.1532857345469019 1.0576171881888843 0.4131133977386426 0.96087908050584 0.0568477959966859 0.14043229134863827 0.351396961492071 0.03833214150480456 0.09022225212798778 1.3604287351494416e-07 6.866324203418938 -0.6445037904502418 down LFTLTALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFTLTALR 8 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQQ5;A0A1B0GTT3 P47897 QARS Glutamine--tRNA ligase 0 8298000.0 5883000.0 1201500.0 1213500.0 False True 5696247.385191393 1681265.2157397254 895647.9457803419 1.0 0.29515312486436807 0.15723473459189452 22.441580372517297 -13.999999999999998 0.22935632598317518 5.436276510811174 0.08976562705679564 0.9995089216763533 0.00817926187004509 13.271293039459737 0.1516426693124227 26.80174961058869 0.07187968243345987 1.0000000000000041e-14 13.999999999999998 -5.346510883754378 LFTLTALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFTLTALR 8 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQQ5;A0A1B0GTT3 P47897 QARS Glutamine--tRNA ligase 0 25113900.0 7392800.0 7964600.0 9756500.0 False True 11215418.086075237 6543254.902296169 7828123.498574145 1.0 0.5834160485216418 0.6979787501897351 23.41898006613058 -10.268099797337559 8.180397031576657 1.000000370020781 0.6406973993556915 0.9291540896711502 0.04677002710692066 3.1564344285390623e-07 2.821148771966423e-08 0.04528493058052641 0.015094961340564424 5.3938666160787706e-11 10.268099797337559 -0.3593029706650894 LFTLTALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFTLTALR 8 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQQ5;A0A1B0GTT3 P47897 QARS Glutamine--tRNA ligase 0 20954100.0 6201900.0 7909200.0 6843000.0 False True 8494910.0300456 7559745.3917731885 5226824.336008839 1.0 0.8899147095184253 0.6152889574488857 23.01816723716988 -6.955507536767513 0.4947027205380163 1.0057616328343895 0.4877033853433423 0.9995655966050665 0.003371767801660572 0.08134671986206869 0.027371719340538024 0.003994750274873353 0.02265114856429035 1.1078793390156528e-07 6.955507536767513 -0.5180582474910471 LFTLTALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFTLTALR 8 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQQ5;A0A1B0GTT3 P47897 QARS Glutamine--tRNA ligase 0 12330100.0 5883000.0 3614800.0 2832300.0 False True 4891975.161089616 3595326.354918379 3424520.834924416 1.0 0.7349437060750678 0.7000282548780673 22.221985647951573 -13.99999999967902 0.285710949639308 3.229695948314939 0.690095706302281 0.9996178735023121 0.0026182413247144184 15.715467671594444 0.16941733518802973 20.544061025942927 0.01344714507825848 1.000000000739085e-14 13.99999999967902 -2.539600242012658 LFTLTALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFTLTALR 8 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQQ5;A0A1B0GTT3 P47897 QARS Glutamine--tRNA ligase 0 32342800.0 7392800.0 13807000.0 11143000.0 False True 9570125.333874315 13038628.312671557 9115088.3368352 1.0 1.3624302564272763 0.9524523471569938 23.19010638822303 -6.673367510749 1.9254900116366664 1.230664020422787 0.954084294466424 0.2940508143402747 0.15383386014857361 0.45341537829925793 3.244039449209896 0.06424658408402652 0.17089717403290974 2.1214484799485428e-07 6.673367510749 -0.27657972595636304 LFTSDLQDK(ub)NEYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFTSDLQDKNEYK 13 1 Q8NFH4;F8VTY2 Q8NFH4 NUP37 Nucleoporin Nup37 1 12641700.0 4351700.0 5241000.0 3049000.0 True False 5705120.841922749 4459063.229257987 2733518.7280732105 1.0 0.7815896197135039 0.4791342381368307 22.443826014330035 -6.966551093581323 0.3303502582352609 1.0366985310031966 0.2141188448232885 0.9999416401770197 0.001631476633821074 0.0774384681900581 0.013024988196153863 0.004407810970274229 0.02637339289823206 1.0800625469444045e-07 6.966551093581323 -0.8225796861799082 down LFTSDLQDK(ub)NEYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFTSDLQDKNEYK 13 1 Q8NFH4;F8VTY2 Q8NFH4 NUP37 Nucleoporin Nup37 1 20285400.0 6554900.0 6317800.0 7412700.0 True False 6346818.287470856 8840530.486891761 5471091.493766735 1.0 1.3929074516508058 0.8620211334184756 22.597602107467562 -6.708476554400164 1.8007829267579536 1.2419276085988633 0.8633313441488922 0.45780398235369435 0.16560907581532952 0.37814178469435705 2.389431852726663 0.07321381271543695 0.18633164125731155 1.9566963982949155e-07 6.708476554400164 -0.3785962644499711 LFTSDLQDK(ub)NEYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFTSDLQDKNEYK 13 1 Q8NFH4;F8VTY2 Q8NFH4 NUP37 Nucleoporin Nup37 1 63061000.0 13596000.0 17477000.0 31988000.0 True False 20626126.000741113 14358092.801575746 25665557.77916152 1.0 0.6961119504971437 1.2443227476763856 24.297969543877556 -6.756232126878683 1.6265097135174893 0.8226577771472117 1.2459697072687135 0.675420218809885 0.12775724518345494 0.28931151729732224 1.5075590104001217 0.06199884578432842 0.1495611041881015 1.7529433174176e-07 6.756232126878683 0.4233119301215018 LFTSDLQDK(ub)NEYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFTSDLQDKNEYK 13 1 Q8NFH4;F8VTY2 Q8NFH4 NUP37 Nucleoporin Nup37 1 15778300.0 4351700.0 5198400.0 6228200.0 True False 5960641.0902706385 4968717.499190024 4757227.433805384 1.0 0.8335877674802968 0.7981066737218002 22.507036075852927 -13.999999999999995 0.21720790129789833 1.992086730107527 0.7786124391221585 0.9994952500486145 0.001977295009506692 12.925094932292172 0.14766461451827387 5.492057550781439 0.020003994831685107 1.0000000000000123e-14 13.999999999999995 -1.2134742909853684 LFTSDLQDK(ub)NEYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFTSDLQDKNEYK 13 1 Q8NFH4;F8VTY2 Q8NFH4 NUP37 Nucleoporin Nup37 1 17213900.0 6554900.0 6924000.0 3735000.0 True False 5450689.7813065285 6886699.037693612 4515971.231311196 1.0 1.2634545927218175 0.8285137134017412 22.37800738290184 -6.742731200211544 1.6767762569371196 1.1562564989663846 0.8281075417886287 0.617117165871301 0.11068785530782976 0.31289173915504764 1.7283575822300912 0.052201568549347266 0.1277119919341724 1.8082929944361734e-07 6.742731200211544 -0.32814895717775594 LFTSDLQDK(ub)NEYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFTSDLQDKNEYK 13 1 Q8NFH4;F8VTY2 Q8NFH4 NUP37 Nucleoporin Nup37 1 90329000.0 13596000.0 13307000.0 63426000.0 True False 17600290.01722692 12566453.7522069 51883118.80571738 1.0 0.7139912887746184 2.947855902086551 24.069095865970006 -6.87473970630132 1.1086565000994157 0.8325192869394529 3.091064348677048 0.9691917867552944 0.17421204708490923 0.13239461897585073 0.30127812727329367 0.12156113149035752 0.2904307790847556 1.334320915647868e-07 6.87473970630132 2.2585450617375953 up LFVALQGCMDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFVALQGCMDK 11 0 P49748-2;P49748;P49748-3;G3V1M7 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 21559600.0 5347600.0 0.0 16212000.0 False True 8112700.161927256 0.0 13007691.094027981 1.0 0.0 1.6033738255325671 22.95175073800543 -6.738063029493471 1.6939127155242768 0.40367449623340085 1.6039032385119625 0.5961856169592975 0.4201793441363493 0.3213195892018445 1.8095664428035867 0.1963006654493492 0.482709007585767 1.8278349217985761e-07 6.738063029493471 1.2002287422785616 LFVASNQGALHIVQLSGGSFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFVASNQGALHIVQLSGGSFK 21 0 Q969X6;H3BSH7;Q969X6-3;A0A0J9YWM9;A0A0J9YWK2;H3BRM8 Q969X6 CIRH1A Cirhin 0 15122600.0 2073100.0 2544500.0 10505000.0 False True 2839581.0934209717 2432075.576463722 8023935.357266249 1.0 0.8564909740026797 2.825746155253996 21.43724668249766 -6.889369899196738 1.0260794222646672 0.8925860485911693 2.9930589367198874 0.9804927651596552 0.12519964641390716 0.11965682611366947 0.2248341943284525 0.0930450703958918 0.23144810406993213 1.2901199788975333e-07 6.889369899196738 2.100472888128718 up LFVGGLDWSTTQETLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFVGGLDWSTTQETLR 16 0 K7EQ02;K7EQ55;K7EK33;Q96EP5-2;Q96EP5 K7EQ02 DAZAP1 DAZ-associated protein 1 0 20621600.0 8124300.0 7462800.0 5034500.0 False True 7866398.54351698 10442734.95798788 3715813.418237434 1.0 1.3275115543941216 0.4723652631736778 22.907271850213434 -6.802903303194813 1.4440432001525034 1.1800484018935797 0.45970165169381844 0.84048655899292 0.1406992576422953 0.2166566116352658 0.891610431815095 0.07664006431459107 0.17792967940381643 1.5743333548955924e-07 6.802903303194813 -0.7203467501997614 down LFVGGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFVGGLK 7 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 258877000.0 60581000.0 117691000.0 80605000.0 False True 79422277.66723844 100131961.5559249 72264767.81775704 1.0 1.2607540918866038 0.9098803250207735 26.243040399187638 -6.707696712835533 1.803373636784913 1.1606812206271768 0.9107578294837503 0.4541740531774705 0.10992071693950156 0.37972478196324555 2.405805182620027 0.04853185037914711 0.1236412338061366 1.960213099678361e-07 6.707696712835533 -0.24992339114342654 LFVGGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFVGGLK 7 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 111394600.0 29578000.0 20926600.0 60890000.0 False True 28639062.580178626 29282700.510777358 44941082.33915535 1.0 1.0224741270352962 1.5692232318476622 24.77148093498895 -6.915548271217776 0.8570962618803866 0.9858940569890966 1.6489544861740382 0.9928520116630303 0.022252208476234027 0.10086317381735048 0.11971300247078827 0.018733398559343806 0.05393426159186189 1.2146516061589577e-07 6.915548271217776 0.6630604291849416 LFVGGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFVGGLK 7 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 331059400.0 15239000.0 307340000.0 8480400.0 False True 23118677.12013045 252492775.74161994 6804245.222908642 1.0 10.92159272044867 0.2943181042562287 24.462555511581694 -6.66171612414034 1.967371117836521 7.3778559525397345 0.3393351566742694 0.2425433295178996 4.222770257566704 0.4805020229322348 3.577174976015927 1.733259357430841 4.680365792925964 2.17913369401452e-07 6.66171612414034 -7.038520795865465 LFVGGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFVGGLK 7 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 174374000.0 60581000.0 59802000.0 53991000.0 False True 82979432.83996713 57159749.90123139 41239437.77954899 1.0 0.6888423787068877 0.49698384729964035 26.30625046071053 -9.233052438485354 0.11075432150093567 1.636954110319893 1.279749258493787e-10 0.9999385029089993 0.0016254160812085683 0.6828043874479179 0.03931161015061581 0.3475317745770663 0.21481498342415487 5.847194784695862e-10 9.233052438485354 -1.636954110191918 LFVGGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFVGGLK 7 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 53742000.0 29578000.0 14080000.0 10084000.0 False True 24595417.527572412 14004148.245338822 12192517.77685197 1.0 0.5693803827334759 0.4957231469310772 24.551886210423227 -13.999999999999998 0.2484269553654483 3.9711795251589717 0.46566039710339957 0.999539757196221 0.004771192810362093 13.936185163772292 0.1577216483012422 20.643800069346096 0.034292296207538146 1.0000000000000041e-14 13.999999999999998 -3.505519128055572 LFVGGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFVGGLK 7 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 42108000.0 15239000.0 15332000.0 11537000.0 False True 19727185.905598767 14478760.722088823 9437384.379616605 1.0 0.7339496262353167 0.4783948620334228 24.233681833674144 -6.971615648476511 0.2161422426046871 1.1237449937538686 0.08141543789215444 0.9999923902918636 0.000587433305071234 0.07578186858882638 0.00712366407500678 0.007292365398841999 0.026117947260724406 1.0675404788426782e-07 6.971615648476511 -1.042329555861714 down LFVGGLSFDTNEQSLEQVFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFVGGLSFDTNEQSLEQVFSK 21 0 Q14011;K7ENX8;K7ELV6;K7EJV5;K7ELT6;K7EJV1;K7EMY9;K7EPM4;K7ER40;K7EQR7;D6W5Y5;Q14011-2;K7EQX4;K7ENN6;K7EIF7;K7EQL0 Q14011 CIRBP Cold-inducible RNA-binding protein 0 65644000.0 14282000.0 31887000.0 19475000.0 False True 21666838.154058877 26196515.71573185 15625757.713804254 1.0 1.2090603866362672 0.7211831095381612 24.368985300232914 -6.790244518269535 1.4951813523207722 1.1168060577373304 0.7159461600578678 0.802172409657942 0.08889004026576183 0.23498438823434312 1.0377623707811903 0.046792544519187816 0.10954155722949441 1.6208972361577235e-07 6.790244518269535 -0.4008598976794626 LFVGGLSFDTNEQSLEQVFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFVGGLSFDTNEQSLEQVFSK 21 0 Q14011;K7ENX8;K7ELV6;K7EJV5;K7ELT6;K7EJV1;K7EMY9;K7EPM4;K7ER40;K7EQR7;D6W5Y5;Q14011-2;K7EQX4;K7ENN6;K7EIF7;K7EQL0 Q14011 CIRBP Cold-inducible RNA-binding protein 0 31987000.0 14282000.0 8086500.0 9618500.0 False True 18488330.54030853 7636479.166395203 7868031.694144245 1.0 0.4130431976941368 0.42556745061379375 24.140111622325364 -9.950348335998486 5.384066646531122 1.0000012958457716 0.4193053241518325 0.9996512467200922 0.005113004851269858 7.953240834179227e-08 1.549658757748943e-08 0.004950656720505933 0.0016502152187550087 1.121118874095792e-10 9.950348335998486 -0.580695971693939 LFVGLEHAVPTFNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFVGLEHAVPTFNVK 15 0 Q7Z7F0-3;Q7Z7F0-2;Q7Z7F0 Q7Z7F0-3 KIAA0907 UPF0469 protein KIAA0907 0 2864340.0 892180.0 1201500.0 770660.0 False True 1169656.6198834097 1022240.8834103171 690919.4958927194 1.0 0.8739666548565451 0.5907028474404646 20.157653624345407 -6.957701003965582 0.46671580921434125 1.0077255855162746 0.44539567256963025 0.9996751687999265 0.0030847375998319386 0.08053295694333878 0.024245807901098513 0.003892844045253304 0.023385247541245976 1.1022979406082698e-07 6.957701003965582 -0.5623299129466444 LFVGLEHAVPTFNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFVGLEHAVPTFNVK 15 0 Q7Z7F0-3;Q7Z7F0-2;Q7Z7F0 Q7Z7F0-3 KIAA0907 UPF0469 protein KIAA0907 0 3713680.0 892180.0 1249200.0 1572300.0 False True 1222043.0562579345 1194006.213448017 1200955.1225349568 1.0 0.9770574018105628 0.9827437064389924 20.2208636858683 -10.160961334379452 5.429373996855678 1.0000005594088883 0.9799005541247733 0.9433710425591515 0.0023214241436283495 1.572088341549703e-08 2.430697365381299e-09 0.002247771829439818 0.0007492364206441748 6.903012592340866e-11 10.160961334379452 -0.02010000528411504 LFVGNLPADITEDEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFVGNLPADITEDEFK 16 0 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 12427100.0 5315700.0 2227200.0 4884200.0 False True 5146956.013167064 3116532.5746945674 3604881.4971407796 1.0 0.60550985217705 0.7003909666060264 22.295288022384085 -9.807599434704853 6.140364016165581 1.0000000165431429 0.6529504093912261 0.94691767028045 0.03873505276406296 8.832404152282001e-09 1.6382808082049818e-09 0.03750505580239735 0.012501684522307998 1.557401416255793e-10 9.807599434704853 -0.3470496071519168 LFVGNLPADITEDEFKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFVGNLPADITEDEFKR 17 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 19114600.0 6897100.0 3586100.0 8631400.0 False True 6678155.335781663 5018048.431264452 6370577.403550416 1.0 0.7514123555014763 0.9539426807604731 22.671018220610126 -9.985570218848352 5.919640757781841 1.0000001456159544 0.8526775183193664 0.41366148688876236 0.08268265905418157 1.5895092393249242e-07 2.7205672245989198e-08 0.08005721971474705 0.02668571346140042 1.0337839402434884e-10 9.985570218848352 -0.14732262729658796 LFVGSIPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFVGSIPK 8 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5;O43390;O43390-3;B4DT28;O43390-2;O43390-4 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 8459600.0 1136200.0 3034600.0 4288800.0 False True 1489569.2029764517 2581849.508778153 3845036.117074575 1.0 1.7332860424471122 2.581307474262651 20.506463719747288 -6.969219027422876 0.2762015282048572 0.8044232881039907 3.535878051544803 0.9999756346897397 0.0031893830919993067 0.07655691928440903 0.009933677856093249 0.016014786489395822 0.07821802810815594 1.0734479045959857e-07 6.969219027422876 2.731454763440812 LFVGSIPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFVGSIPK 8 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5;O43390;O43390-3;B4DT28;O43390-2;O43390-4 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 4907880.0 1927000.0 717480.0 2263400.0 False True 1865828.439786469 1003973.505608772 1670547.6394554775 1.0 0.5380845763738438 0.8953382871828558 20.83138490789971 -9.81342146366366 6.253307879551615 1.000000010769316 0.7167114317782023 0.4560442073467802 0.14584821670017922 2.187190576805022e-08 4.206366468769251e-09 0.14121693384896505 0.047072309529409335 1.5366626530526354e-10 9.81342146366366 -0.2832885789911138 LFVGSIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFVGSIPK 8 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5;O43390;O43390-3;B4DT28;O43390-2;O43390-4 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 7719400.0 1136200.0 4042300.0 2540900.0 False True 1556283.8446504807 3863697.8199014715 1940791.751478134 1.0 2.4826434028615156 1.2470679806574798 20.56967378127018 -6.601340001014321 2.185904642458378 1.9962404060113854 1.2511427538146003 0.024383680377476624 0.6406252147086436 0.6368495504085345 5.7530310884832625 0.24311331858112778 0.7123267877256471 2.5041480348450743e-07 6.601340001014321 -0.7450976521967851 LFVK(ub)LATSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFVKLATSK 9 1 Q9H939-2;Q9H939 Q9H939-2 PSTPIP2 Proline-serine-threonine phosphatase-interacting protein 2 1 25345400.0 5824800.0 6568500.0 12952100.0 True False 7636369.207443439 5588505.403812457 11611940.93731619 1.0 0.7318275546925027 1.5206102038646352 22.864455425977887 -6.814949728961432 1.3934342904748465 0.8546748994989741 1.5360548966868972 0.8724024501763845 0.11697490746413843 0.20012703111566416 0.7648264853071853 0.06598735911802088 0.15234336738086776 1.531264700433492e-07 6.814949728961432 0.6813799971879231 LFVK(ub)LATSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFVKLATSK 9 1 Q9H939-2;Q9H939 Q9H939-2 PSTPIP2 Proline-serine-threonine phosphatase-interacting protein 2 1 26922300.0 5686200.0 6563400.0 14672700.0 True False 5505694.693468511 9184199.847678838 10829479.698435266 1.0 1.6681273406922097 1.96695972104709 22.392493179905813 -10.371567757683856 0.17543075233462382 4.551788795241487e-20 2.2922771259744423 0.9995444132544491 0.008628337532812674 2.0771533232074435 0.08854038030106376 1.1362312881506123 0.2186947714454289 4.250423874391195e-11 10.371567757683856 2.2922771259744423 LFVK(ub)LATSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFVKLATSK 9 1 Q9H939-2;Q9H939 Q9H939-2 PSTPIP2 Proline-serine-threonine phosphatase-interacting protein 2 1 61334000.0 12484000.0 26928000.0 21922000.0 True False 18939140.70265164 22122488.01057571 17589107.091246083 1.0 1.1680829852791779 0.928717272203562 24.174867539255093 -6.717933283562577 1.7664113756048239 1.1024804965400485 0.9291236771790017 0.5029450047200416 0.0707480881120687 0.3593260255100651 2.1899298552649156 0.03181348376119801 0.0800688125052718 1.9145500161299048e-07 6.717933283562577 -0.17335681936104685 LFVK(ub)LATSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFVKLATSK 9 1 Q9H939-2;Q9H939 Q9H939-2 PSTPIP2 Proline-serine-threonine phosphatase-interacting protein 2 1 30514800.0 5824800.0 8467600.0 16222400.0 True False 7978385.969301285 8093473.433391311 12391003.23081541 1.0 1.0144249055551902 1.5530714205219838 22.92766548750078 -6.9126429873526485 0.8775480671808389 0.9846835239467185 1.6267647942862022 0.991881054031106 0.023191973529008862 0.1026965358063203 0.1294813236694203 0.01923918375821275 0.0541332770585769 1.2228044559594796e-07 6.9126429873526485 0.6420812703394837 LFVK(ub)LATSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFVKLATSK 9 1 Q9H939-2;Q9H939 Q9H939-2 PSTPIP2 Proline-serine-threonine phosphatase-interacting protein 2 1 31887100.0 5686200.0 9466900.0 16734000.0 True False 4728327.241371363 9415899.930667484 20233002.030725986 1.0 1.9913807674480197 4.279103581007177 22.17289845534009 -6.957153827369661 0.47384450489575336 0.9417781602008091 5.423101391387217 0.9996496431722028 0.02570174194224206 0.08073392546254705 0.025010033230100377 0.03186453657837605 0.18877155169084275 1.1036876238329307e-07 6.957153827369661 4.4813232311864075 LFVK(ub)LATSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFVKLATSK 9 1 Q9H939-2;Q9H939 Q9H939-2 PSTPIP2 Proline-serine-threonine phosphatase-interacting protein 2 1 52407000.0 12484000.0 26100000.0 13823000.0 True False 16160784.096429873 24647512.056256104 11307355.835957369 1.0 1.5251433290109395 0.6996786646296024 23.945993861347542 -6.734768081502198 1.7054059880919887 1.3143186021811817 0.6996802916776459 0.5814970476977932 0.22068665346382527 0.3273297637432308 1.8670398031284006 0.10245131754232857 0.2529078925690912 1.841755258458775e-07 6.734768081502198 -0.6146383105035358 LFVLFGAEILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFVLFGAEILK 11 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 1102250000.0 315600000.0 395830000.0 390820000.0 False True 478788273.4505651 325191043.8660944 313574255.6975092 1.0 0.6791959241659882 0.6549330321681025 28.834812577124065 -13.99999999999617 0.3662405894248529 5.36435944769989 0.6522677534324711 0.999784395062056 0.0023091124463389605 22.387067499491785 0.19610365199086663 76.58190474640668 0.006861954355182608 1.0000000000088185e-14 13.99999999999617 -4.712091694267419 LFVLFGAEILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFVLFGAEILK 11 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 678320000.0 315600000.0 215610000.0 147110000.0 False True 408550421.40606105 203611113.96357748 120337489.47606799 1.0 0.4983745048232541 0.29454746139268756 28.605938899216515 -13.741909057404646 0.12776853361129245 3.2394848992450798 9.853818405757193e-16 0.9996656707864331 0.005420122733472457 10.909088386124246 0.10832482812152626 6.232775029937712 0.25769060374419395 1.8117194325017123e-14 13.741909057404646 -3.239484899245079 LFVLFGAEILKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFVLFGAEILKK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 25878100.0 5124100.0 10129000.0 10625000.0 False True 7773634.321888607 8321400.811761795 8524964.09289706 1.0 1.0704646587672402 1.0966510308946351 22.890157813043714 -13.999999756443676 0.1374776234892362 0.6640762099575337 1.1300644053856006 0.9996131593500549 0.000802729791480713 11.932069372255826 0.11597568202254001 1.0769079827442247 0.029822887336522764 1.0000005608093172e-14 13.999999756443676 0.4659881954280669 LFVLFGAEILKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFVLFGAEILKK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 20727600.0 5124100.0 6702900.0 8900600.0 False True 6633248.461111535 6329877.722677347 7280782.127868199 1.0 0.9542651326551769 1.097619389738366 22.661284135136164 -6.820876689016768 1.3679277365662845 0.9753690930388008 1.100811480848828 0.8863926171272244 0.020152029268607995 0.19236465795635296 0.7070344731155291 0.011575309083248964 0.026675141462752457 1.510508978186635e-07 6.820876689016768 0.12544238781002726 LFVSGACDASAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFVSGACDASAK 12 0 P62873;P62873-2;B3KVK2 P62873;B3KVK2 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0 6602100.0 1867300.0 3456000.0 1278800.0 False True 2448048.3829589253 2940378.2713824874 1146482.0431157823 1.0 1.2011111756821118 0.46832491183448094 21.223200640902583 -6.833540831989062 1.3119816398174151 1.1072254459151423 0.4471361215069917 0.9127802384193954 0.09129786436465766 0.17647997814697794 0.5928341327711651 0.05461595854209788 0.12569362379908147 1.4670981451330224e-07 6.833540831989062 -0.6600893244081505 down LFVSGACDASAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFVSGACDASAK 12 0 P62873;P62873-2;B3KVK2 P62873;B3KVK2 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 0 6039200.0 1867300.0 2566800.0 1605100.0 False True 2557691.271885095 2453390.2887274805 1226008.4380721604 1.0 0.9592206517244195 0.4793418390830866 21.286410702425474 -6.923679582853255 0.7969769583564422 1.0092515881858581 0.39500984650427473 0.9951430375472441 0.016476262572626982 0.09605544631713776 0.09475324979354954 0.014479853133490329 0.04502379293372808 1.1921212160775626e-07 6.923679582853255 -0.6142417416815834 down LFVTNDAATILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFVTNDAATILR 12 0 P50990;P50990-2;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 29741400.0 6285400.0 13198000.0 10258000.0 False True 8240220.267900188 11228909.845401073 9196600.561684154 1.0 1.3626953504074808 1.1160624671053454 22.974251471679267 -10.409668854324092 4.926136323137149 0.999704175469993 1.2393789087564513 0.5567483289243675 0.1006874529804021 0.00032752859101985805 3.924980789149052e-05 0.09760957787271961 0.032496735713742814 3.893419015764004e-11 10.409668854324092 0.23967473328645827 LFVTNDAATILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFVTNDAATILR 12 0 P50990;P50990-2;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 34225400.0 6285400.0 14043000.0 13897000.0 False True 8609282.236548262 13422533.82600904 10614814.81769909 1.0 1.5590769889070992 1.2329500330047154 23.03746153320216 -10.232715367841093 5.005318645667559 0.9999428283543241 1.3960135109561793 0.6628465276276682 0.13314077222241139 8.49597209499909e-05 1.3023572856135758e-05 0.12893155219026076 0.04297099945972835 5.851734752025016e-11 10.232715367841093 0.3960706826018552 LFVWEILHSTIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFVWEILHSTIR 12 0 Q09161 Q09161 NCBP1 Nuclear cap-binding protein subunit 1 0 14215500.0 3844700.0 4547000.0 5823800.0 False True 5832690.985219864 3735552.3241268448 4672723.377337778 1.0 0.640450922840383 0.8011265107612484 22.475730211811147 -10.147232643267582 5.037474146164359 1.0000141299099172 0.7207887168003149 0.8010460315464496 0.06559553408970822 1.0409942391539997e-05 1.7622506166509004e-06 0.06351581516281733 0.021170867592669347 7.124712706193445e-11 10.147232643267582 -0.27922541310960236 LFYADHPFIFLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFYADHPFIFLVR 13 0 P50454;E9PKH2;H0YEP8 P50454 SERPINH1 Serpin H1 0 16576700.0 7554300.0 6216800.0 2805600.0 False True 7314492.8815147495 8699200.66018371 2070729.1938041402 1.0 1.189310154661358 0.283099488556111 22.80232641418213 -6.852172304808272 1.224472635604551 1.1012479547522807 0.24530813986342917 0.9434161364730426 0.09284192970668569 0.1550861311875135 0.44635246804828493 0.059293697140573524 0.13742087921148124 1.4054897903665845e-07 6.852172304808272 -0.8559398148888515 down LFYADHPFIFLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFYADHPFIFLVR 13 0 P50454;E9PKH2;H0YEP8 P50454 SERPINH1 Serpin H1 0 73017000.0 14491000.0 21423000.0 37103000.0 False True 21983906.43400551 17599898.271337006 29769575.787177365 1.0 0.8005810215837181 1.3541531336363721 24.38994443321984 -6.809295316239832 1.4177702504879268 0.8912283284397204 1.3636565154938611 0.8579048009675542 0.08629213392192181 0.2077688526784231 0.8232900437082944 0.04786292639425334 0.11073831937594367 1.551331759938225e-07 6.809295316239832 0.4724281870541407 LFYADHPFIFLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFYADHPFIFLVR 13 0 P50454;E9PKH2;H0YEP8 P50454 SERPINH1 Serpin H1 0 17533300.0 1197700.0 5509600.0 10826000.0 False True 1640522.0566254873 5266167.654189239 8269121.768468761 1.0 3.2100559897509786 5.040542877843494 20.645723560175504 -7.55086498954596 0.22906780205579855 4.372249322902986e-14 7.23426167134458 0.9998878958301798 0.017490924826833728 0.13595381202721624 0.025005536086997873 0.2103667372865404 0.4535081257225254 2.812775110499354e-08 7.55086498954596 7.2342616713445365 LFYADHPFIFLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFYADHPFIFLVR 13 0 P50454;E9PKH2;H0YEP8 P50454 SERPINH1 Serpin H1 0 18194700.0 7554300.0 4617000.0 6023400.0 False True 6281735.1622334225 4592127.304597251 7282865.0909450855 1.0 0.7310284795522255 1.1593715594268572 22.582731689616406 -6.736937300084492 1.6977652985806626 0.8394008172960159 1.1594664156967602 0.5911974441371431 0.11302142652058329 0.3233758930834405 1.8289366014368458 0.05268866440117112 0.1297376896082702 1.8325789761654817e-07 6.736937300084492 0.32006559840074433 LFYADHPFIFLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFYADHPFIFLVR 13 0 P50454;E9PKH2;H0YEP8 P50454 SERPINH1 Serpin H1 0 73411000.0 14491000.0 24536000.0 34384000.0 False True 18758885.16031442 23170550.03112258 28126464.809633065 1.0 1.23517734839282 1.4993676100292113 24.161070755312288 -6.9696171161168445 0.26717243418806613 0.9320317662914326 1.810425684358433 0.9999792398531757 0.0009293852313162515 0.07642712059697243 0.009473785449625079 0.005269872751830461 0.024668110267223806 1.072464397550059e-07 6.9696171161168445 0.8783939180670004 LFYLPHVCSYTCLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFYLPHVCSYTCLSR 15 0 Q15047-3;Q15047;E9PQM8;E9PRF4 Q15047-3 SETDB1 Histone-lysine N-methyltransferase SETDB1 0 12409700.0 6367700.0 0.0 6042000.0 False True 9660266.441226758 0.0 4847796.051697328 1.0 0.0 0.5018283999920095 23.203631550117674 -9.67242896365448 11.385703295119328 1.0000000000272613 0.25091419263052706 0.7481693793204693 0.2048705864029536 0.0 0.0 0.19836509231659688 0.0661216974388656 2.1260380669364149e-10 9.67242896365448 -0.7490858073967342 LFYSFFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LFYSFFK 7 0 Q9Y333 Q9Y333 LSM2 U6 snRNA-associated Sm-like protein LSm2 0 17795100.0 5139700.0 8374200.0 4281200.0 False True 6738196.472925603 7124802.002375938 3838222.4921702314 1.0 1.057375223623077 0.569621635046172 22.683931064626076 -6.8775705181856 1.0932975335069235 1.0345338910860629 0.5366308786573647 0.9716706263101577 0.03663671509025932 0.12980204634722986 0.2854972989057861 0.02586829699706527 0.06218589818597464 1.3256518487277018e-07 6.8775705181856 -0.49790301242869817 LFYSFFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LFYSFFK 7 0 Q9Y333 Q9Y333 LSM2 U6 snRNA-associated Sm-like protein LSm2 0 22426000.0 12145000.0 4006300.0 6274700.0 False True 11759463.622836895 5606036.482578499 4631167.833034942 1.0 0.4767255261278727 0.3938247509895951 23.48731892112722 -13.999999999999998 0.259331252398598 4.817299392857462 0.3633304166227834 0.9995609720988408 0.00562286987835219 14.38759854137824 0.16114773437809973 28.770551537339955 0.036371081050522586 1.0000000000000041e-14 13.999999999999998 -4.453968976234679 LFYSFFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LFYSFFK 7 0 Q9Y333 Q9Y333 LSM2 U6 snRNA-associated Sm-like protein LSm2 0 22456400.0 8139000.0 4788500.0 9528900.0 False True 12347458.040602531 3933954.7622787384 7645508.738334767 1.0 0.3186044244363975 0.6191969807221699 23.557710730338908 -10.480256194029858 6.210288958857155 1.0003143522022717 0.46890070257959915 0.8062880268971617 0.12271639722982917 0.0005344177783313372 4.472566508710561e-05 0.11888755196195624 0.03960654689814183 3.3093584200569146e-11 10.480256194029858 -0.5314136496226726 LFYSFFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LFYSFFK 7 0 Q9Y333 Q9Y333 LSM2 U6 snRNA-associated Sm-like protein LSm2 0 24888100.0 5139700.0 9127400.0 10621000.0 False True 7039985.985169932 8724121.287724476 8112538.546361225 1.0 1.2392242408013674 1.1523515193710152 22.747141126148968 -10.12519674013465 4.231431562899761 0.999962647553775 1.195787880108816 0.8713398381152928 0.03546564010466685 5089322.451233044 6089002.840354751 1452.361883110329 0.01214083222630626 7.495545760154592e-11 10.12519674013465 0.19582523255504103 LFYSFFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LFYSFFK 7 0 Q9Y333 Q9Y333 LSM2 U6 snRNA-associated Sm-like protein LSm2 0 23842600.0 12145000.0 6436400.0 5261200.0 False True 10099105.614726054 6401725.83567463 6361292.594959695 1.0 0.6338903740485619 0.6298867283538405 23.267724196561495 LFYSFFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LFYSFFK 7 0 Q9Y333 Q9Y333 LSM2 U6 snRNA-associated Sm-like protein LSm2 0 39167000.0 8139000.0 19637000.0 11391000.0 False True 10536095.943675345 18544183.68768968 9317954.881530086 1.0 1.7600621508027807 0.8843840195972693 23.328837052431357 -6.677197020083695 1.9117084443002024 1.482105838299244 0.8877782635202826 0.3113633006302211 0.32233207081316145 0.4448051944856226 3.1404086394474047 0.1354110936824703 0.35844336230800466 2.102824265539778e-07 6.677197020083695 -0.5943275747789615 LGAAPEEESAYVAGEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGAAPEEESAYVAGEKR 17 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 102208290.0 42419000.0 37394290.0 22395000.0 True False 55611719.78618037 31815207.693800755 20077780.22800903 1.0 0.5720953751498061 0.36103505349601506 25.728885617225917 -11.254372659850812 0.12745034883788672 2.0768824068411345 6.644101589012668e-14 0.999762639333984 0.004095299321268713 3.7648737191950787 0.0790379626336987 1.4088441171367558 0.25067526450153826 5.567078434878144e-12 11.254372659850812 -2.076882406841068 LGAAPEEESAYVAGEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGAAPEEESAYVAGEKR 17 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 182601900.0 60854000.0 55848900.0 65899000.0 True False 58922223.07979549 78149657.01816596 48638074.97237633 1.0 1.3263188816269151 0.8254623201590369 25.8123085271327 -6.7309029501237765 1.7201852977560308 1.1961813253650633 0.8257241769425933 0.5633559616295856 0.1371668141851102 0.3345389845415651 1.9397890111170002 0.06318330181198283 0.15661023896632217 1.858219656865651e-07 6.7309029501237765 -0.37045714842247 LGAAPEEESAYVAGEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGAAPEEESAYVAGEKR 17 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 330718700.0 85395100.0 132807100.0 112516500.0 True False 129550609.91805573 109106635.37839168 90277564.45726612 1.0 0.8421931432619622 0.696851713120989 26.948940566771928 -6.972111224599875 0.2014820588478791 1.0848735064867179 0.4501520484043149 0.9999945024546493 0.00029020195021436707 0.07562343413252685 0.006517478865892761 0.004661706330601714 0.01537240356413337 1.0663229965602126e-07 6.972111224599875 -0.634721458082403 LGAAPEEESAYVAGEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGAAPEEESAYVAGEKR 17 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 105285000.0 42419000.0 35921000.0 26945000.0 True False 58102450.6303721 34333891.44513786 20581145.949694343 1.0 0.5909198505852761 0.3542216503160004 25.792095678748808 -9.1536845874156 0.1599002852299636 1.5062063437210809 2.010153676410794e-22 0.9997856148569949 0.0039057284881685904 0.59929741433175 0.055262715816359394 0.31367854848792687 0.16812267606524653 7.019649254113158e-10 9.1536845874156 -1.5062063437210809 LGAAPEEESAYVAGEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGAAPEEESAYVAGEKR 17 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 180083000.0 60854000.0 87482000.0 31747000.0 True False 50602797.28929922 87010717.10218267 38385150.918456905 1.0 1.719484332155339 0.758557885624518 25.592713802566976 -6.706310512458669 1.8082609053830647 1.4439850811232653 0.761046863488446 0.447558155962419 0.3033687768353316 0.3825674715599301 2.4360630371449647 0.13362341707767553 0.34100588632670403 1.9664797905642693e-07 6.706310512458669 -0.6829382176348193 LGAAPEEESAYVAGEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGAAPEEESAYVAGEKR 17 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 378240800.0 85395100.0 173353400.0 119492300.0 True False 110545640.33907716 163706130.90011436 97745927.49453573 1.0 1.4808917873014058 0.884213318541728 26.720066888864377 -6.692239352178915 1.8586720633712839 1.300862340073765 0.886232146722578 0.38078881905434037 0.20329320246772956 0.411896442366643 2.7606387376142547 0.08744680683588328 0.22705898058515844 2.0312372291389634e-07 6.692239352178915 -0.4146301933511871 LGAASLGAEDPETQVVLINAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGAASLGAEDPETQVVLINAVK 22 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 8684800.0 1021000.0 5104300.0 2559500.0 False True 1338540.887378065 4342758.336405569 2294667.492457651 1.0 3.2443972218974704 1.7143051169340429 20.35222977787076 -10.356561281441845 6.220265039117545 0.9998528668822667 2.4793511694157546 0.5548368819541776 0.6246574861035742 0.0012746931029854313 0.00013185681865240985 0.6048794512974646 0.20160733673024434 4.399858589277561e-11 10.356561281441845 1.479498302533488 LGAASLGAEDPETQVVLINAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGAASLGAEDPETQVVLINAVK 22 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 6393400.0 2315400.0 1275400.0 2802600.0 False True 2241898.8943858813 1784673.8711231367 2068514.9838022103 1.0 0.7960545748036549 0.9226620294885485 21.09628978597904 -10.347823017405684 5.308015054266674 1.0000485676408317 0.8593583021790293 0.6219728182732414 0.0516872769351086 2.9717747801062274e-05 3.651354779906391e-06 0.0500632552562131 0.016681996898371007 4.489282987918688e-11 10.347823017405684 -0.1406902654618024 LGAEASCQK(ub)GER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGAEASCQKGER 12 1 Q15572-2;Q15572-6;Q15572;H3BR71;Q15572-5;Q15572-4 Q15572-2 TAF1C TATA box-binding protein-associated factor RNA polymerase I subunit C 1 8114370.0 1360700.0 2910100.0 3843570.0 True False 1783890.8770375424 2475924.423480952 3445874.2465268495 1.0 1.3879349097813933 1.9316620152513568 20.766595935719263 -6.966360306714776 0.3338826123718677 0.9366851441214079 2.4008153044351794 0.9999385023286117 0.002996580204339955 0.07750233090925737 0.013248603445374313 0.007827804249741437 0.047279601422343984 1.0805371258902463e-07 6.966360306714776 1.4641301603137715 LGAEASCQK(ub)GER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGAEASCQKGER 12 1 Q15572-2;Q15572-6;Q15572;H3BR71;Q15572-5;Q15572-4 Q15572-2 TAF1C TATA box-binding protein-associated factor RNA polymerase I subunit C 1 23297160.0 3319290.0 3817970.0 16159900.0 True False 5035605.6026037065 3136623.423564234 12965888.681864223 1.0 0.6228890169520849 2.5748419763374817 22.263733862418924 -6.856619416006246 1.2026499399552675 0.7969519383796367 2.6634607357603444 0.9493988096537433 0.19017247952879204 0.15032984271321323 0.41509443837371673 0.1234867446715444 0.2872540672555522 1.3911712181377558e-07 6.856619416006246 1.8665087973807077 up LGAEASCQK(ub)GER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGAEASCQKGER 12 1 Q15572-2;Q15572-6;Q15572;H3BR71;Q15572-5;Q15572-4 Q15572-2 TAF1C TATA box-binding protein-associated factor RNA polymerase I subunit C 1 8199700.0 1360700.0 1993800.0 4845200.0 True False 1863787.561534859 1905707.3233850927 3700863.550026312 1.0 1.0224917059837615 1.985668123559421 20.829805997242154 -6.911930679992091 0.882495228022967 0.9719667738172376 2.1154180040215573 0.9916294598690695 0.042034359449330115 0.10315572922493886 0.13194959309852924 0.034745763430877805 0.09724546204654447 1.2248116822458758e-07 6.911930679992091 1.1434512302043198 LGAEASCQK(ub)GER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGAEASCQKGER 12 1 Q15572-2;Q15572-6;Q15572;H3BR71;Q15572-5;Q15572-4 Q15572-2 TAF1C TATA box-binding protein-associated factor RNA polymerase I subunit C 1 14247390.0 3319290.0 2171800.0 8756300.0 True False 4296886.337987729 2050937.420834365 7162743.247225169 1.0 0.4773078130325499 1.6669613026300216 22.034860184511373 -6.78728446005016 1.5071607217361715 0.7068255768722617 1.6786824116002186 0.7923810281095719 0.22184020517404568 0.23943948100829984 1.0745136303524987 0.11587442046356879 0.2718372836405654 1.6319826597571786e-07 6.78728446005016 0.9718568347279569 LGAELIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGAELIR 7 0 K7EKX9;K7EN83;B4DKV7;Q8TE68-3;Q8TE68 K7EKX9 EPS8L1 Epidermal growth factor receptor kinase substrate 8-like protein 1 0 16871600.0 4226900.0 6240500.0 6404200.0 False True 5541506.833357822 5309441.7252784725 5741554.817424221 1.0 0.9581223816810251 1.0360999255405017 22.401846893148274 -6.760839021629891 1.6094424049563851 0.9757005477344496 1.0363954547057221 0.6943472817914371 0.017615908887834274 0.2815032102931409 1.437350927566984 0.008635431619828292 0.020734064219090822 1.7344467797536407e-07 6.760839021629891 0.060694906971272555 LGAELIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGAELIR 7 0 K7EKX9;K7EN83;B4DKV7;Q8TE68-3;Q8TE68 K7EKX9 EPS8L1 Epidermal growth factor receptor kinase substrate 8-like protein 1 0 14221900.0 4655900.0 3849600.0 5716400.0 False True 4508101.003010808 5386765.355398802 4219103.351675928 1.0 1.1949078673705769 0.9358937053225143 22.104088408461287 -6.705378366920841 1.8115320713420524 1.1203890142906545 0.9365787011133925 0.44311207799224717 0.08219552439177559 0.38448736158443053 2.4565329013186226 0.036146710608332036 0.09235304537281341 1.970705066316034e-07 6.705378366920841 -0.18381031317726204 LGAELIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGAELIR 7 0 K7EKX9;K7EN83;B4DKV7;Q8TE68-3;Q8TE68 K7EKX9 EPS8L1 Epidermal growth factor receptor kinase substrate 8-like protein 1 0 15442300.0 4226900.0 5085600.0 6129800.0 False True 5789699.157677443 4860901.376169738 4682067.487193778 1.0 0.8395775400046356 0.8086892530478225 22.465056954671166 -13.999999999999893 0.23163839991241947 2.0204386474994696 0.7939033196058972 0.9995120702803466 0.001852338102997057 13.342918622684087 0.15237952695686582 6.267955605621981 0.015872037860708833 1.0000000000002453e-14 13.999999999999893 -1.2265353278935724 LGAELIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGAELIR 7 0 K7EKX9;K7EN83;B4DKV7;Q8TE68-3;Q8TE68 K7EKX9 EPS8L1 Epidermal growth factor receptor kinase substrate 8-like protein 1 0 11958500.0 4655900.0 3026600.0 4276000.0 False True 3871587.1413423624 3010295.105066934 5170091.830009824 1.0 0.7775351542321737 1.3353933777704514 21.884493683895563 -6.79850881926233 1.4621858106168668 0.8770231907299635 1.3427968226716824 0.8277114144465171 0.09517492392808588 0.2228952919545236 0.9409997522638712 0.051212621949027565 0.11920132476645538 1.5903443882088898e-07 6.79850881926233 0.46577363194171895 LGAETLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGAETLPR 8 0 Q9UBD9-2;Q9UBD9 Q9UBD9-2 CLCF1 Cardiotrophin-like cytokine factor 1 0 55251700.0 14707000.0 7972700.0 32572000.0 False True 19281019.42279059 6783204.237341195 29201761.892686356 1.0 0.3518073442384119 1.5145341256266371 24.20067799572361 -6.755423654642029 1.6299065819483605 0.6213564753511204 1.5178192128166408 0.6719379143611957 0.2724798806492101 0.2906681684959948 1.5208151850117821 0.13197877241372627 0.3185890103757858 1.7562095941054818e-07 6.755423654642029 0.8964627374655204 LGAETLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGAETLPR 8 0 Q9UBD9-2;Q9UBD9 Q9UBD9-2 CLCF1 Cardiotrophin-like cytokine factor 1 0 25042900.0 7000400.0 3634500.0 14408000.0 False True 6778176.133825223 5085774.803667111 10634112.569265055 1.0 0.7503161179727245 1.568875219426285 22.692465695684973 -6.824845554345066 1.3507036397249594 0.8660384902690835 1.588683054684511 0.8951806621868746 0.11089996825210027 0.18726019685027911 0.6699222091652275 0.06449607152540875 0.1485020644755698 1.4967678484211447e-07 6.824845554345066 0.7226445644154275 LGAETLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGAETLPR 8 0 Q9UBD9-2;Q9UBD9 Q9UBD9-2 CLCF1 Cardiotrophin-like cytokine factor 1 0 11844100.0 2719800.0 6876500.0 2247800.0 False True 4126135.444014099 5649334.848660272 1803521.344754263 1.0 1.3691588473800396 0.43709698075245745 21.976359749055664 -6.799242574181169 1.458970681355752 1.2038782808316553 0.42446511943580145 0.8299462912358515 0.15804013271055373 0.22184180682902999 0.9323339261158297 0.08521984781351258 0.19828496840462412 1.5876597172230505e-07 6.799242574181169 -0.7794131613958538 down LGAETLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGAETLPR 8 0 Q9UBD9-2;Q9UBD9 Q9UBD9-2 CLCF1 Cardiotrophin-like cytokine factor 1 0 43951000.0 14707000.0 14561000.0 14683000.0 False True 20144575.341730867 13917646.873212129 11215177.805877222 1.0 0.6908880746858322 0.5567343870805861 24.2638880572465 -13.999999999999998 0.11365195510283899 2.4830673351106167 0.32308518659055496 0.9997245696244 0.0030802574678979863 11.992425041752258 0.10287826916816128 4.055122843810732 0.20738294048742312 1.0000000000000041e-14 13.999999999999998 -2.159982148520062 LGAETLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGAETLPR 8 0 Q9UBD9-2;Q9UBD9 Q9UBD9-2 CLCF1 Cardiotrophin-like cytokine factor 1 0 16668800.0 7000400.0 5089500.0 4578900.0 False True 5821142.770302857 5062081.853313343 5536326.819558463 1.0 0.8696027658242742 0.9510721585120002 22.47287097111925 -10.287812505697561 4.930037352002795 1.0000276375330792 0.9103374621690369 0.6175904378492512 0.03325974029008587 1.010658290339626e-05 1.4600178474847055e-06 0.032213528512628195 0.01073453502019638 5.154511279312306e-11 10.287812505697561 -0.08969017536404233 LGAEVYHTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGAEVYHTLK 10 0 P09104;P09104-2 P09104 ENO2 Gamma-enolase 0 5455000.0 1941700.0 1182600.0 2330700.0 False True 2545587.5034495476 1006160.6897386955 2089541.5216530785 1.0 0.39525676818229133 0.8208484362928097 21.279567227785055 -10.255203509062593 5.772300451427988 1.000019680614954 0.6080526022375947 0.5307054705613703 0.17374707094179825 4.400771616596554e-05 5.67797094560624e-06 0.16823831461600713 0.05607662601748971 5.5564382326400574e-11 10.255203509062593 -0.3919670783773592 LGAEVYHTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGAEVYHTLK 10 0 P09104;P09104-2 P09104 ENO2 Gamma-enolase 0 3104100.0 1468100.0 0.0 1636000.0 False True 1900484.3905774371 0.0 1338264.786777562 1.0 0.0 0.7041703648883683 20.85793574515336 -10.544913234941443 8.554250057539672 1.0000829071381563 0.3520851847540155 0.530252973728806 0.287476347660991 0.0004546030879295971 2.418468537547093e-05 0.27838265045630467 0.09278259224329599 2.851587912040123e-11 10.544913234941443 -0.6479977223841408 LGAGGGSPEK(ub)SPSAQELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGAGGGSPEKSPSAQELK 18 1 Q9UNE7;H3BS86 Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP 1 7067900.0 3115400.0 2483500.0 1469000.0 True False 4032946.713714966 2345291.0418280475 1201657.0732128613 1.0 0.5815328612828788 0.2979600670463483 21.943402913236316 -8.225049914749206 0.21979193278042197 1.2448808361684258 2.2416696535807147e-22 0.9996871885554508 0.0051001540155245625 0.08811165419695971 0.04704531179032755 0.10169710477226104 0.11039580732109078 5.955936862512917e-09 8.225049914749206 -1.2448808361684258 down LGAGTFQLDQWLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGAGTFQLDQWLR 13 0 P50219 P50219 MNX1 Motor neuron and pancreas homeobox protein 1 0 2699670.0 1059600.0 818620.0 821450.0 False True 1389145.8611809965 696485.0869557671 736454.2339048019 1.0 0.5013764979032822 0.5301489602241609 20.40576666047522 -10.72448697621734 6.820480319569952 1.0063962736668732 0.5157627290638084 0.9973591084926872 0.011746308554934647 0.001145990468796744 4.6292182370406784e-05 0.011408348200887835 0.003791104784389639 1.8858755229712472e-11 10.72448697621734 -0.49063354460306485 LGAGTFQLDQWLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGAGTFQLDQWLR 13 0 P50219 P50219 MNX1 Motor neuron and pancreas homeobox protein 1 0 3986650.0 1059600.0 828350.0 2098700.0 False True 1451362.7546133157 791750.7580128592 1603030.2840832598 1.0 0.5455223068775829 1.1045000837921823 20.46897672199811 -6.690452603903434 1.8646014069935501 0.7151979209239105 1.1025905071412636 0.37265772761294147 0.19219354522700788 0.4156855926749975 2.80234792638272 0.08244395636763477 0.21458371152324096 2.0396112374686572e-07 6.690452603903434 0.38739258621735306 LGAPQTHLGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGAPQTHLGLK 11 0 Q96C19;H0Y4Y4;A0A087X1Z2;Q9BUP0-2;Q9BUP0;C9JTV4;Q8WYH2 Q96C19 EFHD2;EFHD1;PP1187 EF-hand domain-containing protein D2;EF-hand domain-containing protein D1 0 7051700.0 1237700.0 2164400.0 3649600.0 False True 1622636.6859038498 1841479.9567651197 3271974.401435225 1.0 1.1348689283081066 2.016455334616481 20.629908580842773 -6.9340504447220574 0.712762414441578 0.9883964216726 2.21764045868447 0.9972761380424908 0.02352483358694649 0.09058846043847726 0.06777268181372129 0.021974330356048843 0.0780681160041117 1.1639908202239154e-07 6.9340504447220574 1.2292440370118698 up LGAPQTHLGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGAPQTHLGLK 11 0 Q96C19;H0Y4Y4;A0A087X1Z2;Q9BUP0-2;Q9BUP0;C9JTV4;Q8WYH2 Q96C19 EFHD2;EFHD1;PP1187 EF-hand domain-containing protein D2;EF-hand domain-containing protein D1 0 4402160.0 1484400.0 576860.0 2340900.0 False True 1437278.534519481 807203.2062851586 1727748.064505317 1.0 0.561619189947081 1.202096895632653 20.454908242414156 -6.722460243433718 1.7502511909538558 0.7339947821527181 1.201251513809675 0.5241290187383107 0.18441972643898039 0.3505939256197833 2.1001969724855702 0.08361676776913024 0.20932115103814689 1.8946969524277803e-07 6.722460243433718 0.467256731656957 LGAQALLGAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGAQALLGAAK 11 0 P32322-2;P32322;P32322-3;J3QKT4;J3KQ22;J3QL24 P32322-2 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial;Pyrroline-5-carboxylate reductase 0 14011900.0 3338000.0 3878100.0 6795800.0 False True 4376150.325237982 3299502.5967154037 6092635.805916667 1.0 0.7539737786626357 1.392236407140639 22.061230866355558 -6.802187107608378 1.4468501724092695 0.8646322052992363 1.4015432330230482 0.8385237045041505 0.1056193873692886 0.2176423446586302 0.8992209843580676 0.05742122129678595 0.13337366317485283 1.5769317319524623e-07 6.802187107608378 0.5369110277238118 LGAQALLGAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGAQALLGAAK 11 0 P32322-2;P32322;P32322-3;J3QKT4;J3KQ22;J3QL24 P32322-2 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial;Pyrroline-5-carboxylate reductase 0 7058700.0 2847400.0 1672600.0 2538700.0 False True 2757010.845587961 2340477.902493775 1873738.3106325103 1.0 0.8489186418106541 0.6796267463477883 21.394673511987907 -6.969651859247802 0.2663827572353153 1.043973617342201 0.4795068857077052 0.9999795320367048 0.0005920127089972968 0.07641593243791794 0.009434242780138328 0.0033935709803938107 0.015824868581569094 1.0723786048858858e-07 6.969651859247802 -0.5644667316344958 LGAQALLGAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGAQALLGAAK 11 0 P32322-2;P32322;P32322-3;J3QKT4;J3KQ22;J3QL24 P32322-2 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial;Pyrroline-5-carboxylate reductase 0 13249300.0 2350800.0 8668200.0 2230300.0 False True 3566335.466500604 7121291.985044284 1789480.2274247827 1.0 1.9968093444759167 0.5017700225438059 21.766010985437266 -6.727008419923937 1.7342275004678875 1.6018795438178814 0.5031529911544809 0.545259030350443 0.4191441573948978 0.34189712289803487 2.013078642103553 0.19164261045096811 0.4771510022969997 1.8749581567925114e-07 6.727008419923937 -1.0987265526634005 LGAQALLGAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGAQALLGAAK 11 0 P32322-2;P32322;P32322-3;J3QKT4;J3KQ22;J3QL24 P32322-2 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial;Pyrroline-5-carboxylate reductase 0 10754900.0 3338000.0 3296200.0 4120700.0 False True 4572148.80605818 3150562.9849242317 3147475.52848044 1.0 0.6890770879437867 0.6884018132371322 22.12444092787845 LGAQALLGAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGAQALLGAAK 11 0 P32322-2;P32322;P32322-3;J3QKT4;J3KQ22;J3QL24 P32322-2 PYCR1 Pyrroline-5-carboxylate reductase 1, mitochondrial;Pyrroline-5-carboxylate reductase 0 7667600.0 2847400.0 2798600.0 2021600.0 False True 2367739.2612079843 2783523.386321397 2444307.2131777015 1.0 1.175603847909033 1.0323379998905173 21.175078787422184 -10.649625344806818 6.3449870185618495 0.9993780016217547 1.1039709238997728 0.4125340992873292 0.05848803753541461 0.0005176594681381429 2.8585467963614865e-05 0.05696498157538737 0.01887693294391793 2.2406532616404664e-11 10.649625344806818 0.10459292227801809 LGAQSVYHLHIHVLGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGAQSVYHLHIHVLGGR 17 0 Q9BX68 Q9BX68 HINT2 Histidine triad nucleotide-binding protein 2, mitochondrial 0 52116700.0 10036400.0 21339800.0 20740500.0 False True 13157817.592635859 18155985.02188888 18594472.01692437 1.0 1.3798629517443974 1.4131881587514397 23.649416882055032 -11.991124629331903 0.3842261749632097 9.763657594944826e-16 1.416199439242822 0.9996989654078641 0.0032517693036541715 5.5115702832420865 0.197391434156015 4.447724771988454 0.008914684505705404 1.0206465471037175e-12 11.991124629331903 1.4161994392428212 LGAQSVYHLHIHVLGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGAQSVYHLHIHVLGGR 17 0 Q9BX68 Q9BX68 HINT2 Histidine triad nucleotide-binding protein 2, mitochondrial 0 79821600.0 18989400.0 18293200.0 42539000.0 False True 18386591.891272034 25597770.157777783 31396759.757354677 1.0 1.392197657355349 1.707589962458375 24.132150753139026 -6.973596885377971 0.14901276494730914 0.6282590694066639 2.4798167363792825 0.9999985860975115 0.00034411673346766204 0.0751519359636709 0.004550437601571833 0.016255948749686756 0.03950446835082876 1.0626814865890967e-07 6.973596885377971 1.8515576669726186 LGAQSVYHLHIHVLGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGAQSVYHLHIHVLGGR 17 0 Q9BX68 Q9BX68 HINT2 Histidine triad nucleotide-binding protein 2, mitochondrial 0 233391000.0 50621000.0 72868000.0 109902000.0 False True 76795757.89081454 59864136.07971735 88179821.52824229 1.0 0.7795239961669502 1.1482381833331627 26.194523284547103 -6.74472444320747 1.6693175459960201 0.8695478917314899 1.1486909790442525 0.6260969865673313 0.09263058441901936 0.30928169860238697 1.6939269604773803 0.04386715832496073 0.10709632794636507 1.800012648237844e-07 6.74472444320747 0.2791430873127626 LGAQSVYHLHIHVLGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGAQSVYHLHIHVLGGR 17 0 Q9BX68 Q9BX68 HINT2 Histidine triad nucleotide-binding protein 2, mitochondrial 0 113466400.0 10036400.0 45003000.0 58427000.0 False True 13747128.303511783 43014618.65498007 44627745.94183674 1.0 3.128989393660619 3.246332248927678 23.712626943577924 -10.402447975146151 0.5836738107113244 1.2666932003554582e-12 3.2339617512615804 0.9997572820336277 0.016083950423229746 1.7608001003921754 0.28183398455049485 2.762640786007511 0.020816471343444966 3.958694838552832e-11 10.402447975146151 3.233961751260314 LGAQSVYHLHIHVLGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGAQSVYHLHIHVLGGR 17 0 Q9BX68 Q9BX68 HINT2 Histidine triad nucleotide-binding protein 2, mitochondrial 0 38301000.0 18989400.0 7729400.0 11582200.0 False True 15790527.47305713 7687760.188034221 14003984.469957849 1.0 0.4868589856261356 0.8868598274410021 23.912556028573302 -9.861715236535833 6.493932692020797 1.0000000126997375 0.686859406533542 0.4496842110714159 0.1632996598551293 3.010295704449283e-08 5.079387230633042e-09 0.15811422283326754 0.052704738588338976 1.374943218928042e-10 9.861715236535833 -0.31314060616619543 LGAQSVYHLHIHVLGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGAQSVYHLHIHVLGGR 17 0 Q9BX68 Q9BX68 HINT2 Histidine triad nucleotide-binding protein 2, mitochondrial 0 228418000.0 50621000.0 101508000.0 76289000.0 False True 65529882.38908817 95858990.56729674 62405184.79124299 1.0 1.4628286679674993 0.9523164473378408 25.965649606639552 -6.6679989547761265 1.9443438883547102 1.2959301886141525 0.9543935026156094 0.2702124683743188 0.19669113172462746 0.46576265212212825 3.392678012836614 0.08149340956863253 0.21830941149798455 2.1478356433566762e-07 6.6679989547761265 -0.34153668599854314 LGASLAFNNIYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGASLAFNNIYR 12 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 33136000.0 10744000.0 11843000.0 10549000.0 False True 14085488.045043992 10076070.563652439 9457490.673153272 1.0 0.7153511849522123 0.6714350715366877 23.7477062164204 -13.999999999999998 0.2631094114932086 3.1179853767051937 0.6558557126722825 0.9995687407920522 0.0030245429814936206 14.556752272579763 0.16233076539906252 16.423208291631827 0.01889002228863669 1.0000000000000041e-14 13.999999999999998 -2.4621296640329113 LGASLAFNNIYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGASLAFNNIYR 12 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 20958300.0 6456000.0 5123300.0 9379000.0 False True 6251057.813835729 7169060.407656552 6922358.536031168 1.0 1.1468555596764711 1.1073899397810112 22.57566891488177 -10.047821723497826 4.2147611613669875 0.9999880136461908 1.1271227497668492 0.9325872417625012 0.016111771977020257 2304438.8850649977 2746845.0009546154 201.52743749529714 0.005515488340066908 8.957323853835357e-11 10.047821723497826 0.1271347361206584 LGASLAFNNIYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGASLAFNNIYR 12 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 59376000.0 13474000.0 20479000.0 25423000.0 False True 20441043.081346415 16824362.446842693 20398132.906703237 1.0 0.8230677064711955 0.9979007835132281 24.284965481323166 -10.791980768163699 8.538097750248925 1.0014990321379564 0.9104842449941417 0.2590039477544669 0.07137530481894665 0.002069015729131248 5.040875847355596e-05 0.07020618647283411 0.023036280574521513 1.6144300469518013e-11 10.791980768163699 -0.09101478714381472 LGASLAFNNIYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGASLAFNNIYR 12 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 36066500.0 10744000.0 9868500.0 15454000.0 False True 14716347.14568276 9432477.03923452 11804083.485120645 1.0 0.6409523332019024 0.802106892985569 23.810916277943292 -10.048785053347505 4.589451388343696 1.000010073450602 0.7215296130836324 0.7992442666579963 0.06579107358652128 20724865.361243263 22688956.813514296 2032.0284335256451 0.02252203265968192 8.93747719488098e-11 10.048785053347505 -0.2784804603669697 LGASLAFNNIYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGASLAFNNIYR 12 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 20493800.0 6456000.0 5058800.0 8979000.0 False True 5368450.049293647 5031547.240306815 10856467.385794712 1.0 0.9372439333712047 2.022272217513349 22.356074190316047 -6.893184960083672 1.0033797723921003 0.9460729574976485 2.1216223894382127 0.9828588308080425 0.06511595465747547 0.11659594936365283 0.20707064690196814 0.04923071797359751 0.12422372232730294 1.2788365491574444e-07 6.893184960083672 1.1755494319405642 up LGASLAFNNIYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGASLAFNNIYR 12 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 53905000.0 13474000.0 22291000.0 18140000.0 False True 17442358.6122474 21050486.254636176 14838706.132117981 1.0 1.2068600768164048 0.8507281877405486 24.056091803415615 -6.74921224360542 1.6525863062663455 1.1217481761815673 0.8500546478889424 0.6456689704369913 0.08692092093062899 0.30140928500548664 1.61929636964729 0.04155227622063762 0.10096814690148656 1.7815079157847332e-07 6.74921224360542 -0.27169352829262494 LGASVLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGASVLLR 8 0 Q6F5E8-2;Q6F5E8 Q6F5E8-2 RLTPR Leucine-rich repeat-containing protein 16C 0 4685200.0 1263200.0 1220500.0 2201500.0 False True 1656067.4328462002 1038406.1574717375 1973709.8982791633 1.0 0.6270313254618387 1.1918052726192718 20.659329987965833 -6.728635897625417 1.728560104919079 0.7752089801348695 1.1913660382538747 0.5528337660038121 0.15680373344500806 0.33877020009461195 1.9824661992699595 0.07191132526772824 0.17869506244720754 1.8679450761805007e-07 6.728635897625417 0.41615705811900516 LGASVLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGASVLLR 8 0 Q6F5E8-2;Q6F5E8 Q6F5E8-2 RLTPR Leucine-rich repeat-containing protein 16C 0 6262400.0 1372400.0 2807100.0 2082900.0 False True 2082031.1358794551 2306151.0730275945 1671213.9020325006 1.0 1.1076448537612626 0.8026843946916172 20.989560213006175 -6.811292364483018 1.4089757052748595 1.058576443966172 0.7971838051949122 0.8632078594764329 0.046705515195011406 0.2050400634496959 0.80199079954251 0.0260624134172722 0.060256525412015594 1.5442145334348264e-07 6.811292364483018 -0.26139263877125984 LGAVFNQVAFPLQYTPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGAVFNQVAFPLQYTPR 17 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 28397700.0 7975700.0 11261000.0 9161000.0 False True 10456219.936788673 9580902.6950342 8213107.598517123 1.0 0.9162874110294106 0.785475788398493 23.31785805651502 -6.964568633776862 0.36538197878927114 1.0106011926709957 0.6866415009784242 0.9999039685873514 0.0008650853783528073 0.0781076706944089 0.015378077291274028 0.0017372715301705035 0.011138045603517933 1.085004067344289e-07 6.964568633776862 -0.32395969169257144 LGAVFNQVAFPLQYTPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGAVFNQVAFPLQYTPR 17 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 54420000.0 20342000.0 11322000.0 22756000.0 False True 19696254.34464784 15842933.64345002 16795520.934633255 1.0 0.8043627669620899 0.8527266474499596 24.231417961294436 -10.853263556776794 7.214424471511102 1.0149806928449348 0.8285447072072779 0.9436844187342671 0.019744471529371414 0.004873143811472883 9.9116285598041e-05 0.01958210831991251 0.006372500784410164 1.4019626486271149e-11 10.853263556776794 -0.18643598563765684 LGAVFNQVAFPLQYTPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGAVFNQVAFPLQYTPR 17 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 34562600.0 7060600.0 16695000.0 10807000.0 False True 10711446.39900211 13715646.811369633 8670991.713123623 1.0 1.2804663628478221 0.8095070815022164 23.352649968928425 -6.745404605216971 1.6670371596442775 1.1658243223661466 0.8088994803629673 0.6288999390107228 0.11783629449956068 0.308122796838316 1.6832448212575275 0.0558768012944145 0.13630490201120077 1.797195799154988e-07 6.745404605216971 -0.3569248420031793 LGAVFNQVAFPLQYTPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGAVFNQVAFPLQYTPR 17 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 54419700.0 7975700.0 16685000.0 29759000.0 False True 10924531.825188208 15947801.530083371 22730537.10584351 1.0 1.4598155587146748 2.080687526895635 23.381068118037913 -6.966945872132697 0.32291646377753275 0.917829842508873 2.6427854905776043 0.9999478205328532 0.0031987135087558206 0.07730671460077952 0.012563799719323202 0.009302552743572305 0.054474464919948756 1.079081204077916e-07 6.966945872132697 1.7249556480687311 LGAVFNQVAFPLQYTPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGAVFNQVAFPLQYTPR 17 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 44937700.0 20342000.0 9654700.0 14941000.0 False True 16915274.30339706 9602688.21479209 18065094.02062133 1.0 0.5676933192188082 1.067975233306938 24.011823236728713 -6.67812023852691 1.9084530748637851 0.7260134203800046 1.0660482687080444 0.315552967084858 0.18329787922859114 0.44273568722933543 3.115982245317813 0.07711188789118491 0.20387694807142712 2.098358852739104e-07 6.67812023852691 0.34003484832803976 LGAVFNQVAFPLQYTPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGAVFNQVAFPLQYTPR 17 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 34131300.0 7060600.0 17591000.0 9479700.0 False True 9140085.885233333 16612045.386268243 7754491.869935983 1.0 1.817493357814784 0.8484047050875192 23.123776291020874 -6.683084457474605 1.8908378452646424 1.5158128062277947 0.8519981971931887 0.3382218082374555 0.34624483068613787 0.43177443902340584 2.987178639628594 0.14678933336921107 0.38563673206321053 2.0745100471728397e-07 6.683084457474605 -0.663814609034606 LGAVYDVSHYNALLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGAVYDVSHYNALLK 15 0 P42704;B8ZZ38;A0A0C4DG06;C9JCA9 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 47138000.0 11487000.0 16020000.0 19631000.0 False True 15059568.240266223 13629878.445470907 17599772.433848873 1.0 0.9050643569599415 1.1686770930650363 23.844177072564275 -6.8093225870073555 1.4176311292676274 0.9482196910707142 1.173206609759162 0.8579838933888442 0.041081941218703115 0.20773059604421992 0.8229681330334268 0.02278865965651029 0.05272504436682585 1.551234349813756e-07 6.8093225870073555 0.22498691868844778 LGAVYDVSHYNALLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGAVYDVSHYNALLK 15 0 P42704;B8ZZ38;A0A0C4DG06;C9JCA9 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 16426600.0 4616000.0 3185200.0 8625400.0 False True 4469467.6066706525 4457066.970598565 6366148.983546561 1.0 0.9972254780292894 1.4243640504397264 22.091671560249473 -6.905436734335171 0.9262498533483621 0.9847914490726889 1.4744984002760604 0.9890824744160389 0.020970980994374964 0.10751387296434418 0.1557080788414226 0.016790852107449846 0.04500812928664414 1.2432637345718633e-07 6.905436734335171 0.4897069512033715 LGAVYDVSHYNALLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGAVYDVSHYNALLK 15 0 P42704;B8ZZ38;A0A0C4DG06;C9JCA9 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 28570700.0 11487000.0 8274400.0 8809300.0 False True 15734054.324502774 7908809.6482182685 6728724.773228508 1.0 0.5026555447887207 0.4276535872098655 23.907387134087166 -13.999999999999998 0.26636053115834823 4.764774225566074 0.40186620735648737 0.9995755638659949 0.005232475098217721 14.707882441482347 0.1633498367956354 29.918586267792605 0.03172714687430482 1.0000000000000041e-14 13.999999999999998 -4.362908018209587 LGAVYDVSHYNALLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGAVYDVSHYNALLK 15 0 P42704;B8ZZ38;A0A0C4DG06;C9JCA9 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 15016800.0 4616000.0 5539400.0 4861400.0 False True 3838408.5234726584 5509558.152715183 5877896.263426037 1.0 1.4353756560884805 1.5313368098995954 21.87207683568375 -11.968021034756577 0.2495187894247709 2.2133610351453026e-07 1.5740384050438103 0.9993724627259389 0.005791707667121554 5.097375291107005 0.14513751361571295 2.682886863668763 0.04430536688687957 1.0764130770351264e-12 11.968021034756577 1.5740381837077069 LGCEVLGVSVDSQFTHLAWINTPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGCEVLGVSVDSQFTHLAWINTPR 24 0 P32119;A6NIW5 P32119 PRDX2 Peroxiredoxin-2 0 163939000.0 46708000.0 63943000.0 53288000.0 False True 70859450.81219591 52531872.06106067 42755603.443039864 1.0 0.741353079355495 0.6033860402948681 26.07845694827358 -13.999999999933241 0.07801423193634209 2.4120875960139667 0.17581180147063483 0.9998947487745057 0.0016865666154596967 12.278409388148422 0.07800730814863002 3.020232441076145 0.3892953846009755 1.0000000001537184e-14 13.999999999933241 -2.236275794543332 LGCEVLGVSVDSQFTHLAWINTPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGCEVLGVSVDSQFTHLAWINTPR 24 0 P32119;A6NIW5 P32119 PRDX2 Peroxiredoxin-2 0 94901000.0 46708000.0 27701000.0 20492000.0 False True 60464426.75232677 26159414.998863984 16762666.26567592 1.0 0.43264141254522565 0.277231872789249 25.84958327036603 -13.999999999999998 0.18170703561840912 3.9593701699766473 0.15593344400448816 0.9994961788396753 0.006972477510548695 12.227306607758171 0.13514514719040652 12.780594582295382 0.11437274276994383 1.0000000000000041e-14 13.999999999999998 -3.8034367259721593 LGCFNLSIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGCFNLSIR 9 0 O15379-2;O15379;E7ESJ6 O15379-2 HDAC3 Histone deacetylase 3 0 19430200.0 6919000.0 6772600.0 5738600.0 False True 8956781.893880038 6395698.856406133 4694233.683008385 1.0 0.7140621410884378 0.5240982462926608 23.09454904494492 -8.31933207544678 0.1144101257304351 1.4933366262725116 6.300078737369301e-10 0.9999721447264683 0.0010323158758131646 0.09294868952895542 0.02463575240438831 0.15204296954139224 0.14916020499518057 4.793667693083356e-09 8.31933207544678 -1.4933366256425038 LGCFNLTIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGCFNLTIK 9 0 Q13547 Q13547 HDAC1 Histone deacetylase 1 0 70454000.0 19404000.0 22168000.0 28882000.0 False True 25438831.908603296 18860620.8101872 25893567.695706967 1.0 0.7414106464459409 1.0178756551691308 24.600529091187777 -11.057399449780178 12.119671517476606 1.597218546918267 0.8796431508075375 0.20172233617538615 0.11286636718431925 0.04042387733706501 0.00019145006260421453 0.002425486116002042 0.03642746337098331 8.761945554787326e-12 11.057399449780178 -0.7175753961107294 LGCFNLTIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGCFNLTIK 9 0 Q13547 Q13547 HDAC1 Histone deacetylase 1 0 228566000.0 56409000.0 76601000.0 95556000.0 False True 85576577.05029461 62930953.063655354 76669314.7163174 1.0 0.7353759081374558 0.8959147159071076 26.350712638436715 -10.304349878410791 5.444134388793752 1.0000300912515097 0.8156453122755255 0.6374546946059583 0.06553969382508851 2.394126964987294e-05 3.0592036395143566e-06 0.06346888471767341 0.021152845225005292 4.961924154629287e-11 10.304349878410791 -0.18438477897598415 LGCFNLTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGCFNLTIK 9 0 Q13547 Q13547 HDAC1 Histone deacetylase 1 0 80112000.0 19404000.0 22024000.0 38684000.0 False True 26578183.17338314 21050906.85637139 29547635.921988357 1.0 0.7920370899337067 1.1117251969118414 24.66373915271067 -6.731154948866528 1.719242042213662 0.8750099465143583 1.1115680272981352 0.5645464521574055 0.08741463486422517 0.33406104661838726 1.9350026872815924 0.040285965358995555 0.09982792264281433 1.8571417403669237e-07 6.731154948866528 0.23655808078377694 LGCFNLTIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGCFNLTIK 9 0 Q13547 Q13547 HDAC1 Histone deacetylase 1 0 191431000.0 56409000.0 69202000.0 65820000.0 False True 73022562.48762529 65350847.8665531 53841435.370231844 1.0 0.894940490175591 0.7373260200141024 26.121838960529164 -6.965255004681624 0.3536562464074272 1.0146048718807053 0.612313225363081 0.9999182943904983 0.0009757490177638106 0.07787460824882013 0.014555944695652901 0.002144222155015828 0.013515174739750816 1.0832906514937544e-07 6.965255004681624 -0.4022916465176243 LGCFNLTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGCFNLTVK 9 0 Q92769-3;Q92769 Q92769-3 HDAC2 Histone deacetylase 2 0 38878000.0 13202000.0 11425000.0 14251000.0 False True 17307949.848349873 9720434.5343012 12776443.225244794 1.0 0.5616167494978003 0.7381835131942499 24.04493150972566 -10.146668356027828 5.271145910528978 1.0000111213201346 0.6499001313458275 0.8397973226016273 0.07208307943250382 9.42129703508439e-06 1.5252503120802799e-06 0.06979635760004788 0.023264713848686454 7.133976000220855e-11 10.146668356027828 -0.3501109899743071 LGCFNLTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGCFNLTVK 9 0 Q92769-3;Q92769 Q92769-3 HDAC2 Histone deacetylase 2 0 13089300.0 8169900.0 1832300.0 3087100.0 False True 7910550.996477151 2563946.9453182686 2278495.8989851605 1.0 0.32411736508115363 0.28803251505487487 22.915346756082933 -13.616607706807692 0.420807785587012 9.999778939338388 0.28686502752957 0.999859353927928 0.003883377281324744 21.456437890545956 0.2160335190196875 175.5305333199542 0.008740713156646153 2.417643678054584e-14 13.616607706807692 -9.712913911808817 LGCFNLTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGCFNLTVK 9 0 Q92769-3;Q92769 Q92769-3 HDAC2 Histone deacetylase 2 0 81767000.0 22377000.0 22789000.0 36601000.0 False True 33947544.97783051 18722124.8987303 29366796.307211835 1.0 0.5515015860780746 0.8650639192433462 25.016803909480483 -10.163650254905447 5.603053219196573 1.0000060096610104 0.7082827526606854 0.5357528105905578 0.12801128646867208 9.610329586936129e-06 1.4342876103663556e-06 0.12394894875862197 0.041315465051633145 6.860404846931253e-11 10.163650254905447 -0.291723257000325 LGCFNLTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGCFNLTVK 9 0 Q92769-3;Q92769 Q92769-3 HDAC2 Histone deacetylase 2 0 52536900.0 13202000.0 9672900.0 29662000.0 False True 18083136.17063515 9245519.293997213 22656446.508065786 1.0 0.5112785308231451 1.2529047115653063 24.108141571248552 -6.729004371843296 1.7272537354357236 0.7055592161547343 1.252352394739464 0.5544956107677638 0.20546276899116092 0.3380945829737149 1.975701671228949 0.09429181565542291 0.2342078033891194 1.8663609029411762e-07 6.729004371843296 0.5467931785847296 LGCFNLTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGCFNLTVK 9 0 Q92769-3;Q92769 Q92769-3 HDAC2 Histone deacetylase 2 0 91064000.0 22377000.0 41082000.0 27605000.0 False True 28967467.61661419 38795750.58601963 22581173.251219217 1.0 1.3392869235061633 0.7795356345981678 24.787930231572933 -6.742589256572487 1.6772615205429497 1.2012522799277754 0.7790160493456627 0.6166462332096097 0.14254656800244972 0.31307285989279715 1.7303012347982076 0.06720888994487778 0.1644552831654387 1.8088841086431782e-07 6.742589256572487 -0.4222362305821127 LGCHPQTGFADIQGHPFFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGCHPQTGFADIQGHPFFR 19 0 P41743 P41743 PRKCI Protein kinase C iota type 0 7212400.0 2041600.0 2554400.0 2616400.0 False True 2676557.3708825214 2173293.476973212 2345680.026280995 1.0 0.8119734329687198 0.8763795059276355 21.351947145870465 -10.419084153307045 8.113426878731206 1.0000030158851798 0.8441764707525853 0.8864231236773725 0.02629366918096817 1.4344314627393043e-06 1.0273051968776583e-07 0.02545922843427347 0.00848624523738142 3.809919913653417e-11 10.419084153307045 -0.15582654513259453 LGCTLPQLAIAWCLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGCTLPQLAIAWCLR 15 0 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28;Q13303-5;A0A590UJJ4 Q13303-3 KCNAB2 Voltage-gated potassium channel subunit beta-2 0 119272000.0 29368000.0 34162000.0 55742000.0 False True 44553403.08839103 28065524.19107573 44724569.26741349 1.0 0.6299299771870529 1.003841820537993 25.40903229643543 -10.963406297863711 10.948285103213328 1.0727919714540262 0.8168858988784193 0.24229481963325472 0.15264887083221307 0.0871772256415825 0.00029138215298144156 0.04750697488755962 0.049267211212544015 1.0879118370599795e-11 10.963406297863711 -0.2559060725756068 LGCTLPQLAIAWCLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGCTLPQLAIAWCLR 15 0 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28;Q13303-5;A0A590UJJ4 Q13303-3 KCNAB2 Voltage-gated potassium channel subunit beta-2 0 72508000.0 29368000.0 20530000.0 22610000.0 False True 38017454.9298264 19387487.45267962 18495211.99819112 1.0 0.5099627917877602 0.48649263956069805 25.18015861852788 -13.8609758107332 0.4346115942895344 9.999999999912278 0.48613145010937076 0.999879552628041 0.00259808901870418 28.675204828025308 0.22176272073228306 245.24606239459249 0.0054946116046256455 1.3772861786299412e-14 13.8609758107332 -9.513868549802908 LGDGVDKDEAK(ub)AEVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGDGVDKDEAKAEVLK 16 2 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 25888900.0 4185000.0 8356900.0 13347000.0 True False 6348950.964482313 6865545.902242278 10708959.599802082 1.0 1.0813669755287025 1.6867289824273008 22.59808680477359 -6.931472170641872 0.73460393597713 0.9912789831297317 1.815799448877622 0.9968198579570267 0.017276199039251847 0.09188031495502996 0.07398682559848666 0.015879663658038667 0.054338045613423765 1.1709216319482225e-07 6.931472170641872 0.8245204657478902 LGDGVDKDEAK(ub)AEVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGDGVDKDEAKAEVLK 16 2 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 3800030.0 619400.0 814130.0 2366500.0 True False 515058.5440725661 809744.1200978485 2861324.2085402803 1.0 1.5721399623724412 5.555337818329932 18.974376899825568 -6.932776045213223 0.7236417595041318 0.9452257778129242 6.43404823536317 0.9970562770341025 0.10992614652285036 0.09122181062880907 0.07080487004431152 0.10185588725307934 0.3550695365780901 1.1674114667220884e-07 6.932776045213223 5.488822457550246 up LGDGVDKDEAK(ub)AEVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGDGVDKDEAKAEVLK 16 2 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 41795400.0 4185000.0 4722400.0 32888000.0 True False 5417564.998683042 4459594.28867677 26902721.459376846 1.0 0.8231731949244457 4.965832706375768 22.36921312686604 -6.896929626930215 0.9804816064231076 0.8129553667566476 5.374538668043386 0.984975639540543 0.23442905411233333 0.11370051144683024 0.1904428710142626 0.18030908254067105 0.4623046621097502 1.2678572927858927e-07 6.896929626930215 4.561583301286738 up LGDHLAEK(ub)TSSLPNHSEPDHDTDAGLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGDHLAEKTSSLPNHSEPDHDTDAGLER 28 1 Q69YN4-2;Q69YN4-3;Q69YN4;Q69YN4-4 Q69YN4-2 KIAA1429 Protein virilizer homolog 1 33142200.0 1240200.0 12857000.0 19045000.0 True False 1881474.0707648636 10562567.89780051 15280747.40227997 1.0 5.613985364946633 8.121689073327481 20.843431976595124 -8.524163638555983 0.35083382746008274 1.3597924109586312e-22 9.013240553301054 0.9978949577052992 0.1353251919842486 0.1929648368055995 0.10437861827256768 0.8958787226473071 0.6979510505852191 2.9911373885121724e-09 8.524163638555983 9.013240553301054 LGDHLAEK(ub)TSSLPNHSEPDHDTDAGLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGDHLAEKTSSLPNHSEPDHDTDAGLER 28 1 Q69YN4-2;Q69YN4-3;Q69YN4;Q69YN4-4 Q69YN4-2 KIAA1429 Protein virilizer homolog 1 21277100.0 1240200.0 7425900.0 12611000.0 True False 1605463.3479968219 7012642.137109274 10315927.399787188 1.0 4.367986441957164 6.425514112582288 20.614558298687573 -8.38116660085723 0.3037930256618659 1.1288922594399069e-18 7.538382992194586 0.9987442722595506 0.07924926739810743 0.13055399605620255 0.08017543114264913 0.6783560105274903 0.6407461531734292 4.157510925209401e-09 8.38116660085723 7.538382992194586 LGDK(ub)HATLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGDKHATLQK 10 1 Q13263;Q13263-2;M0R3C0 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 14992000.0 3193200.0 6540400.0 5258400.0 True False 4186316.122992783 5564597.814279516 4714311.210134533 1.0 1.3292349767177651 1.1261240364151688 21.99724982784897 -10.244331520239928 4.156453667694483 0.9998413740841817 1.2276795065790191 0.6262249088590084 0.0829196942682724 58544095.581139505 26.41125880366659 92221.82513613136 0.028385616864771444 5.69729201429869e-11 10.244331520239928 0.22783813249483742 LGDK(ub)HATLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGDKHATLQK 10 1 Q13263;Q13263-2;M0R3C0 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 18367500.0 4396900.0 6762800.0 7207800.0 True False 4257322.816241381 9463221.307536101 5319860.950634972 1.0 2.2228103707415823 1.2495789443873235 22.021515057548807 -10.30978119251178 4.885539839912213 0.9996874631876779 1.736194657564905 0.4327665270386245 0.39732006603639475 0.00135311582864064 0.00019116391847848362 0.38486196579235854 0.12823449990585964 4.900256433068373e-11 10.30978119251178 0.7365071943772271 LGDK(ub)HATLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGDKHATLQK 10 1 Q13263;Q13263-2;M0R3C0 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 12805300.0 3193200.0 5314800.0 4297300.0 True False 4373812.33298531 5079974.562306695 3282366.245671608 1.0 1.1614523385001752 0.7504588664944515 22.060459889371863 -6.800135419601195 1.4552813053105578 1.0890645647657382 0.7447610296834345 0.8325876277016873 0.0691756056766591 0.2205594828421951 0.9221655236670361 0.037394161723708304 0.08696091197697985 1.5843990757851693e-07 6.800135419601195 -0.3443035350823037 LGDK(ub)HATLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGDKHATLQK 10 1 Q13263;Q13263-2;M0R3C0 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 15119300.0 4396900.0 8526500.0 2195900.0 True False 3656217.165696913 8480566.052122269 2655052.53730556 1.0 2.319491886775217 0.7261747366145521 21.801920332983084 -6.686782956134918 1.8776270825834407 1.829702212533417 0.7318498384203805 0.35552622674276413 0.5584193041835018 0.42361110392683493 2.892864216477363 0.23813549979086132 0.6226981694992989 2.0569183086994003e-07 6.686782956134918 -1.0978523741130366 LGDK(ub)ILQVSFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGDKILQVSFK 11 1 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 1 6460900.0 2232500.0 2222600.0 2005800.0 True False 2161630.5095087155 3110095.770705881 1480420.8072898276 1.0 1.4387730729303632 0.68486302389685 21.043688511612576 -6.748959480256972 1.6539975976981331 1.2583277224028535 0.6835096879186513 0.644373177298913 0.18436527403133787 0.30185585731140335 1.6244704756933104 0.0880716668026379 0.21402299630611496 1.782545071423594e-07 6.748959480256972 -0.5748180344842022 LGDK(ub)ILQVSFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGDKILQVSFK 11 1 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 1 4291800.0 1151300.0 1330200.0 1810300.0 True False 1576966.722712636 1271427.3656168366 1382744.4242988192 1.0 0.8062486971378682 0.8768380488843016 20.588720785899017 -10.739416793389006 9.506020774685721 1.0005282032014593 0.841543373722722 0.8704434393384226 0.02881798217543376 0.00032363309069607596 8.871536190949461e-06 0.027992176353628388 0.009300963753063095 1.822146145181837e-11 10.739416793389006 -0.15898482947873727 LGDK(ub)ILQVSFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGDKILQVSFK 11 1 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 1 5262020.0 2232500.0 2184200.0 845320.0 True False 1856422.6665192174 2172433.2810702473 1022072.5036819234 1.0 1.1702255742996006 0.5505602372321299 20.824093787046852 -6.833468802364034 1.3123273530630104 1.0907611767771248 0.5326706636069305 0.9126409138906225 0.07726014248117134 0.17656644650681233 0.5934677735585494 0.04620687080709733 0.10633928034186262 1.4673414899081722e-07 6.833468802364034 -0.5580905131701943 LGDVISIQPCPDVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGDVISIQPCPDVK 14 0 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 0 24474000.0 0.0 11929000.0 12545000.0 False True 0.0 10149239.698877811 11246963.74013723 0.0 LGDVISIQPCPDVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGDVISIQPCPDVK 14 0 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 0 19428000.0 0.0 8773000.0 10655000.0 False True 0.0 8385379.851568574 8138508.44661321 0.0 LGDVISIQPCPDVK(ub)YGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGDVISIQPCPDVKYGK 17 1 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 1 180987500.0 105872600.0 8083500.0 67031400.0 True False 138800003.87171692 6877473.309236209 60095633.73859186 1.0 0.04954951813684799 0.43296564886362704 27.048432367257917 -10.657371244028687 6.566812899647689 1.004266929122531 0.24125758350023765 0.8392643927520083 0.15652897990547657 0.009792507978110198 0.0005109317775047073 0.1517775935348084 0.0505195110310622 2.2010441599562803e-11 10.657371244028687 -0.7630093456222934 LGDVISIQPCPDVK(ub)YGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGDVISIQPCPDVKYGK 17 1 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 1 254634000.0 228531000.0 13784000.0 12319000.0 True False 346698234.85402805 11324137.505116455 9884144.250390481 1.0 0.03266280692165713 0.02850935844698502 28.369105250459885 LGDVISIQPCPDVK(ub)YGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGDVISIQPCPDVKYGK 17 1 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 1 354611200.0 105872600.0 123488600.0 125250000.0 True False 145016561.31943548 118032465.32980847 95668529.60472123 1.0 0.8139240391296568 0.6597076136289511 27.111642428780808 -6.97328148175455 0.16160462135440398 1.1526894836761792 0.3168444163487231 0.9999979741227107 0.00019793930920063716 0.07525162698536705 0.004996718378308349 0.007029505110464543 0.018397739043217138 1.0634535326170891e-07 6.97328148175455 -0.835845067327456 LGDVISIQPCPDVK(ub)YGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGDVISIQPCPDVKYGK 17 1 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 1 193420500.0 3811200.0 94615600.0 94993700.0 True False 3169181.6647874783 94105886.98307393 114856443.46875672 1.0 29.6940651994415 36.24167233608518 21.59567893001502 -8.958535308887319 0.6465187859480833 1.090304311229104e-18 35.5360080224349 0.9960835004907697 0.957818622489314 0.4751080916843543 0.2839939429773668 3.490933988909765 1.099380728127291 1.1001823949411794e-09 8.958535308887319 35.5360080224349 LGDVISIQPCPDVK(ub)YGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGDVISIQPCPDVKYGK 17 1 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 1 247401900.0 228531000.0 13677000.0 5193900.0 True False 295837884.5194825 12915862.926950758 4248663.493914417 1.0 0.04365858330798123 0.014361458475189373 28.140231572552334 -12.879719158930445 0.5114129644429523 9.999999997945206 0.016122617148522568 0.9999347292489887 0.003699265315416867 15.631376879397518 0.2548676776914161 155.81259846107702 0.005843928877414223 1.319109478752667e-13 12.879719158930445 -9.983877380796685 LGDVISIQPCPDVK(ub)YGKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGDVISIQPCPDVKYGKR 18 2 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 1 50423000.0 14342000.0 11668000.0 24413000.0 True False 21757862.5406464 9585754.237499898 19587759.849401962 1.0 0.4405650701943959 0.9002612188035284 24.37503349959236 -10.06863258210739 7.318427854577973 1.000000050329734 0.6704131444989669 0.4066649684250703 0.18767016680250034 1.540938295056356e-07 1.960916916600676e-08 0.18171088472841102 0.060570285883837664 8.538221514488167e-11 10.06863258210739 -0.329586905830767 LGDVISIQPCPDVK(ub)YGKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGDVISIQPCPDVKYGKR 18 2 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 1 6881300.0 2757700.0 2196300.0 1927300.0 True False 2293149.7368242093 2184468.0959685855 2330289.519171639 1.0 0.9526059554200166 1.0161959691297195 21.12889913162214 -6.707132928999174 1.8051585338351896 0.9707790849640282 1.0160361603969088 0.4516265600207868 0.01998068351418224 0.3808524893968767 2.4173176885915235 0.008813864267376728 0.022471781722552382 1.9627594228303122e-07 6.707132928999174 0.0452570754328806 LGDVYVNDAFGTAHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGDVYVNDAFGTAHR 15 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 201319000.0 38189000.0 78414000.0 84716000.0 False True 50066148.82280211 66714936.85537808 75950400.97325362 1.0 1.3325358235861242 1.5170010627752297 25.577332149233143 -11.048034773688096 0.09972641690161667 2.169359705491283e-16 1.9897870363873447 0.9998901396298351 0.0022422935318713163 3.4508508512981595 0.06153137761569624 1.0983802104090294 0.3105429751401864 8.952930771217305e-12 11.048034773688096 1.9897870363873444 LGDVYVNDAFGTAHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGDVYVNDAFGTAHR 15 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 169530000.0 48701000.0 26995000.0 93834000.0 False True 47155013.41257964 37774244.277065285 69256060.44034001 1.0 0.8010652853931364 1.4686892321371798 25.490907827285064 -6.82685344724279 1.3419178622687062 0.893449997935445 1.4855262783748628 0.899433228170298 0.08875446149992088 0.18472555635835985 0.6516620327981955 0.05194674955141686 0.11957058737903849 1.48986374770393e-07 6.82685344724279 0.5920762804394178 LGDVYVNDAFGTAHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGDVYVNDAFGTAHR 15 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 406516000.0 12886000.0 378610000.0 15020000.0 False True 19549004.092788287 311044087.40656793 12051290.416500147 1.0 15.910994029681207 0.616465696119319 24.220591776757313 -6.608690915505278 2.1584046676792625 9.999999999959243 0.6706795264167018 0.23564520984038506 6.225906554716076 0.5132593243147798 4.529447307281677 2.4528484925333025 7.115208567959491 2.462119254655184e-07 6.608690915505278 -9.329320473542541 LGDVYVNDAFGTAHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGDVYVNDAFGTAHR 15 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 205118000.0 38189000.0 91016000.0 75913000.0 False True 52308505.31892031 86994612.1703368 57983912.877311066 1.0 1.6631064420582922 1.1084987522351921 25.640542210756035 -10.616611181483854 3.07950523190101 0.9745629406358456 1.385802597189745 0.39217274636221744 0.22641764285722077 111318261.61483608 144290218.57182896 23321473.859353058 0.08286035930103536 2.4176243351994402e-11 10.616611181483854 0.4112396565538994 LGDVYVNDAFGTAHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGDVYVNDAFGTAHR 15 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 85907000.0 48701000.0 23574000.0 13632000.0 False True 40497039.3201131 23447002.18292739 16482388.172753468 1.0 0.5789806508467964 0.4070023006488622 25.27131310271934 -13.999999999999998 0.12313864062881352 3.002909838169301 0.14377323274582043 0.9996776905114194 0.0044721749730181224 11.952801968156272 0.10838823400519425 5.835683515618138 0.23366913405882161 1.0000000000000041e-14 13.999999999999998 -2.8591366054234806 LGDVYVNDAFGTAHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGDVYVNDAFGTAHR 15 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 55332000.0 12886000.0 30033000.0 12413000.0 False True 16681181.021034548 28361637.148871217 10153961.368135639 1.0 1.700217575308841 0.6087075822348399 23.991718098849763 -6.733469625692266 1.7107826479457173 1.4197534095118831 0.6089576599878188 0.5752044230649918 0.2942822764484711 0.3297623435795477 1.892356555126611 0.13623637971668948 0.3367153094043224 1.8472699873983723e-07 6.733469625692266 -0.8107957495240643 LGEDIVITAHVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGEDIVITAHVLK 13 0 Q9NPJ3-2;Q9NPJ3 Q9NPJ3-2 ACOT13 Acyl-coenzyme A thioesterase 13;Acyl-coenzyme A thioesterase 13, N-terminally processed 0 23457000.0 0.0 23457000.0 0.0 False True 0.0 19270915.079622477 0.0 0.0 LGEFAK(ub)VLELDNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGEFAKVLELDNVK 14 1 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 19331500.0 6330600.0 4772400.0 8228500.0 True False 6129638.56819525 6678044.20773723 6073209.000291337 1.0 1.0894678590655382 0.9907939811987109 22.54737057778425 -6.667960017664423 1.9444246415283453 1.0572063244259544 0.9911946717584807 0.2701042509209829 0.03802186940928128 0.46582748910420607 3.3933745900198304 0.01575265304735965 0.04220218329264735 2.1480282183696065e-07 6.667960017664423 -0.06601165266747366 LGEFAK(ub)VLELDNVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGEFAKVLELDNVK 14 1 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 65710100.0 7358100.0 14407000.0 43945000.0 True False 11162775.649165416 11835958.287595212 35259251.48822223 1.0 1.0603060259909574 3.1586455373093862 23.41219246533845 -6.913045986281614 0.8747254514422313 0.9411213628837596 3.4482695723382655 0.9920213777885665 0.08965211058719709 0.10243835291234879 0.1280929109138497 0.07452317768460584 0.2103323556399759 1.2216702939145496e-07 6.913045986281614 2.507148209454506 up LGEFAK(ub)VLELDNVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGEFAKVLELDNVK 14 1 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 19767900.0 6330600.0 5789900.0 7647400.0 True False 5264174.393131725 5758708.659494839 9246435.982417459 1.0 1.0939433668854783 1.7564835987351544 22.327775853218526 -6.932518804516772 0.7258173020359927 0.9908064977845518 1.9016569221826873 0.9970106015488304 0.018406951031748067 0.09135070804774917 0.07142598324435218 0.017028346319056593 0.05913996745134068 1.1681031510679879e-07 6.932518804516772 0.9108504243981356 LGEFAK(ub)VLELDNVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGEFAKVLELDNVK 14 1 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 57122100.0 7358100.0 10600000.0 39164000.0 True False 9525205.499835042 10010100.68185112 32036553.856574845 1.0 1.0509065323603228 3.3633451642727974 23.1833187874309 -6.911648408575162 0.8844250553694094 0.932080608909987 3.6729803203092612 0.9915290967241458 0.10145191126483824 0.103338324192979 0.1329258621005637 0.0837429466864106 0.23389868434994357 1.2256080122059568e-07 6.911648408575162 2.7408997113992744 up LGEFAK(ub)VLELDSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGEFAKVLELDSVK 14 1 P30154;P30154-2;P30154-4;P30154-3 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 5410450.0 897250.0 1247800.0 3265400.0 True False 1176303.4389813603 1061633.1038863037 2927527.73192859 1.0 0.9025163649998701 2.488752166246944 20.165828834809037 -6.892271808449907 1.00882031950863 0.9193535637507798 2.6314278663441377 0.9823138837274171 0.09653329605381791 0.11732026948487002 0.2112229700514814 0.07268264122376418 0.18275037139641329 1.281528271658228e-07 6.892271808449907 1.7120743025933578 up LGEFAK(ub)VLELDSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGEFAKVLELDSVK 14 1 P30154;P30154-2;P30154-4;P30154-3 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 9910450.0 897250.0 1737100.0 7276100.0 True False 1228987.5722695335 1660349.1781784738 5557635.035983336 1.0 1.350989396184339 4.522124683262844 20.22903889633193 -6.927906234621488 0.7637847900499127 0.9478455910923536 5.139735135350591 0.9961104623182366 0.09879488615220941 0.09373970844534239 0.08311433888861552 0.08891030444189447 0.2903067695410904 1.180575497649673e-07 6.927906234621488 4.191889544258237 up LGEGEGSMTK(ub)EEFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGEGEGSMTKEEFAK 15 1 Q9Y5X3;Q5QPE5;Q5QPE4 Q9Y5X3 SNX5 Sorting nexin-5 1 4284010.0 3307800.0 976210.0 0.0 True False 3202795.6995981787 1366015.7438678988 0.0 1.0 0.42650729924461883 0.0 21.610900343528897 -8.178347081161432 0.5508650928476828 1.0251221879070374 8.070951432145018e-16 0.9910410431890448 0.03878031107435775 0.1251957632839592 0.17218600949871 0.0527005821653613 0.07341425420461276 6.632128295289587e-09 8.178347081161432 -1.0251221879070365 LGEGEGSMTK(ub)EEFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGEGEGSMTKEEFAK 15 1 Q9Y5X3;Q5QPE5;Q5QPE4 Q9Y5X3 SNX5 Sorting nexin-5 1 13426400.0 3634400.0 3862000.0 5930000.0 True False 5513650.51023047 3172795.9260562724 4757932.900788672 1.0 0.5754437863207347 0.8629369765023048 22.394576392505265 -9.937706708065646 5.448054571190715 1.0000004581209518 0.7191903814106148 0.5598707634355615 0.11736860341480955 6.53148212381399e-07 1.2743875137638598e-07 0.11364184617305337 0.037880553865637594 1.1542324820767715e-10 9.937706708065646 -0.2808100767103371 LGEGEGSMTK(ub)EEFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGEGEGSMTKEEFAK 15 1 Q9Y5X3;Q5QPE5;Q5QPE4 Q9Y5X3 SNX5 Sorting nexin-5 1 7707500.0 3307800.0 2854300.0 1545400.0 True False 2750582.260386236 2838923.3193658087 1868535.9948777293 1.0 1.0321172212341572 0.6793238005597222 21.391305618963173 -6.8846537783722965 1.0534522561636315 1.0214557336989414 0.6519732056662901 0.9772515148734952 0.02402340159745108 0.1235898251312444 0.24802545737862688 0.01748591477908565 0.04283437380169163 1.3042060834240122e-07 6.8846537783722965 -0.36948252803265125 LGEGEGSMTK(ub)EEFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGEGEGSMTKEEFAK 15 1 Q9Y5X3;Q5QPE5;Q5QPE4 Q9Y5X3 SNX5 Sorting nexin-5 1 14363300.0 3634400.0 3356500.0 7372400.0 True False 4704802.444734444 3169707.8243993693 6030698.847212044 1.0 0.6737175177136007 1.2818176571816584 22.165702714597714 -6.760924331766025 1.6087330574696805 0.8107019702690468 1.2841638965168884 0.6948718370809754 0.13725471892505806 0.2813443815263821 1.4352273287649262 0.06730708497274998 0.16161888534587399 1.7341061091597005e-07 6.760924331766025 0.47346192624784167 LGEGEGSMTK(ub)EEFTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGEGEGSMTKEEFTK 15 1 A0A0A0MRI2;Q9UNH7;G3V5X9;G3V2U1;H0YJF8;G3V4Z5 A0A0A0MRI2 SNX6 Sorting nexin-6;Sorting nexin-6, N-terminally processed 1 12729800.0 6347100.0 4250800.0 2131900.0 True False 8321109.565403826 3616597.2094886224 1911311.438628822 1.0 0.4346292019185915 0.22969430021392415 22.988344484442365 -13.3967879295435 0.1495879783174675 3.2822043577396016 2.9269741853125604e-18 0.9995741303032684 0.006722358506071006 9.629810167096128 0.1167822481579197 6.558418629450613 0.20137355896886538 4.010625127636413e-14 13.3967879295435 -3.2822043577396016 LGEGEGSMTK(ub)EEFTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGEGEGSMTKEEFTK 15 1 A0A0A0MRI2;Q9UNH7;G3V5X9;G3V2U1;H0YJF8;G3V4Z5 A0A0A0MRI2 SNX6 Sorting nexin-6;Sorting nexin-6, N-terminally processed 1 14774100.0 5325200.0 4395100.0 5053800.0 True False 5156154.4408671055 6150086.350143709 3730058.169249846 1.0 1.1927661245750922 0.7234186275891623 22.297864046316242 -6.795152077243234 1.4754193646021545 1.1070168362321329 0.7176732498493908 0.817692653951289 0.08224643279891353 0.22773606978983515 0.9791240079171405 0.04386331931734496 0.10233498462705892 1.6026840792629722e-07 6.795152077243234 -0.389343586382742 LGEGEGSMTK(ub)EEFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGEGEGSMTKEEFTK 15 1 A0A0A0MRI2;Q9UNH7;G3V5X9;G3V2U1;H0YJF8;G3V4Z5 A0A0A0MRI2 SNX6 Sorting nexin-6;Sorting nexin-6, N-terminally processed 1 29303400.0 9452900.0 7838500.0 12012000.0 True False 14340740.399559097 6439658.432519972 9637822.934953364 1.0 0.44904644063691146 0.6720589499862696 23.77361617522467 -10.247497294097291 5.5682000765557005 1.0000283675076398 0.5605526953115774 0.8381140291455081 0.0910444756939866 3.2064164036064405e-05 4.333263622320343e-06 0.08815911334858686 0.029384478177241706 5.655912810349449e-11 10.247497294097291 -0.43947567219606243 LGEGEGSMTK(ub)EEFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGEGEGSMTKEEFTK 15 1 A0A0A0MRI2;Q9UNH7;G3V5X9;G3V2U1;H0YJF8;G3V4Z5 A0A0A0MRI2 SNX6 Sorting nexin-6;Sorting nexin-6, N-terminally processed 1 11917100.0 6347100.0 3195600.0 2374400.0 True False 8693794.393928055 3054407.8255639477 1813615.6223029974 1.0 0.35133196015047424 0.20861036506334543 23.051554545965256 -13.999999999999957 0.21276048550374557 4.79469923040923 0.12676304646084757 0.9994917407418968 0.0077641237377232015 12.812749182817614 0.14618013826016135 20.352097768136993 0.0829355213487266 1.0000000000000981e-14 13.999999999999957 -4.667936183948383 LGEGEGSMTK(ub)EEFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGEGEGSMTKEEFTK 15 1 A0A0A0MRI2;Q9UNH7;G3V5X9;G3V2U1;H0YJF8;G3V4Z5 A0A0A0MRI2 SNX6 Sorting nexin-6;Sorting nexin-6, N-terminally processed 1 13675500.0 5325200.0 5441700.0 2908600.0 True False 4428139.746359749 5412384.482007115 3516774.8121530786 1.0 1.2222704774519564 0.7941878562084952 22.07826932175052 -6.765561690650214 1.5911797126568725 1.1282056391947548 0.792157852789822 0.7134257212047126 0.09357881486926713 0.2736510703028627 1.3665804578158145 0.04637357940480703 0.11085570161423004 1.7156879828131304e-07 6.765561690650214 -0.3360477864049328 LGEGEGSMTK(ub)EEFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGEGEGSMTKEEFTK 15 1 A0A0A0MRI2;Q9UNH7;G3V5X9;G3V2U1;H0YJF8;G3V4Z5 A0A0A0MRI2 SNX6 Sorting nexin-6;Sorting nexin-6, N-terminally processed 1 34865400.0 9452900.0 9095500.0 16317000.0 True False 12236965.394516343 8589327.429412914 13347473.426558375 1.0 0.7019164598816291 1.0907502796845103 23.54474249731712 -6.701886850124408 1.8242938789354466 0.8152452714076422 1.0896302536140745 0.42649980037892365 0.12578168419720018 0.3915930182374011 2.535011953867385 0.0549803052910617 0.1410584070796993 1.9866124364130235e-07 6.701886850124408 0.27438498220643226 LGEINVIGEPFLNVNCEHIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGEINVIGEPFLNVNCEHIK 20 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 28985200.0 6434100.0 15331000.0 7220100.0 False True 8435167.407913031 13043674.559769938 6473033.312089669 1.0 1.5463444800791584 0.7673864665705764 23.007985270459336 -6.718206572058624 1.7657820571467804 1.3330380122660805 0.7687301136163103 0.5039215611988093 0.2299580182263045 0.3588731808956175 2.1858367359744193 0.10344344985349024 0.2602297975191834 1.9133456261915288e-07 6.718206572058624 -0.5643078986497703 LGEINVIGEPFLNVNCEHIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGEINVIGEPFLNVNCEHIK 20 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 18694300.0 8173000.0 4210400.0 6310900.0 False True 7913552.588674015 5891634.676945936 4657885.967058219 1.0 0.744499339699609 0.5885960717219026 22.915894070779885 -10.392540189803354 0.07859360506589277 1.8956782865822914 1.5467881169890832e-12 0.9999644307119312 0.0010114038984369669 2.238086140026208 0.041489643917951194 0.7101191926214864 0.3312630361033745 4.050044641101062e-11 10.392540189803354 -1.8956782865807447 LGEINVIGEPFLNVNCEHIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGEINVIGEPFLNVNCEHIK 20 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 101514300.0 9012800.0 85507000.0 6994500.0 False True 13673076.523939352 70247607.78075962 5612034.009201747 1.0 5.137659228174974 0.4104441307979211 23.70483455868807 -6.675453178194944 1.9181177203630404 3.628542207906742 0.4290433710998665 0.30344212196916065 1.7554046041852476 0.44868365712660313 3.1875520355324385 0.7354362835966142 1.9509821136978622 2.1112848036668345e-07 6.675453178194944 -3.1994988368068755 LGEINVIGEPFLNVNCEHIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGEINVIGEPFLNVNCEHIK 20 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 53002100.0 6434100.0 19346000.0 27222000.0 False True 8812960.645014659 18491229.751333136 20792724.25468839 1.0 2.098185898718759 2.359334744839747 23.071195331982228 -10.484736920557362 0.30427678424738397 5.025122221259643e-23 2.4393763575193974 0.9990762365875923 0.017900933751825148 2.0399304331868993 0.14687904891523548 1.6687150971554767 0.091907374921892 3.275390457663981e-11 10.484736920557362 2.4393763575193974 LGEINVIGEPFLNVNCEHIK(ub)SFDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGEINVIGEPFLNVNCEHIKSFDK 24 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 23421400.0 9277300.0 8974900.0 5169200.0 True False 8982797.18963727 12558624.373485213 3815231.4473240543 1.0 1.3980750214391 0.42472643729788084 23.09873333090962 -6.7956893571016375 1.4737254906088173 1.220850716017212 0.4127185440408892 0.8191738426851172 0.16990617885462334 0.22697360998863336 0.9736458055306026 0.09072372960597878 0.21154217596031466 1.6007025724986975e-07 6.7956893571016375 -0.8081321719763228 down LGEINVIGEPFLNVNCEHIK(ub)SFDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGEINVIGEPFLNVNCEHIKSFDK 24 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 141993000.0 48715000.0 34627000.0 58651000.0 True False 73904216.54354969 28447541.308014173 47058604.1423535 1.0 0.38492446897466037 0.6367512754109663 26.139153342695682 -10.325399427061441 5.778641560905175 1.0000618269635146 0.5108378721928348 0.8341856080764136 0.10280786322060334 8.190038279156154e-05 9.56097417337016e-06 0.09955579809108961 0.033181095176046185 4.727162947993475e-11 10.325399427061441 -0.4892239547706798 LGEINVIGEPFLNVNCEHIK(ub)SFDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGEINVIGEPFLNVNCEHIKSFDK 24 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 30484200.0 8958200.0 10245000.0 11281000.0 True False 12270288.626252364 9792342.0243155 8616660.139487907 1.0 0.7980531120812203 0.7022377714125245 23.548665849216068 -13.999999999977854 0.09906691116973944 2.0001124108878217 0.4951768265139774 0.9997983814390236 0.0017622324162666796 12.087656916174184 0.093544867971303 2.4774622617263167 0.1847731761310153 1.0000000000509928e-14 13.999999999977854 -1.5049355843738443 LGEINVIGEPFLNVNCEHIK(ub)SFDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGEINVIGEPFLNVNCEHIKSFDK 24 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 30387000.0 9277300.0 9384700.0 11725000.0 True False 7714486.004075582 9334142.758382894 14176643.289725242 1.0 1.2099500541515849 1.8376653068312894 22.879138606343897 -6.951527058359641 0.5418208593079863 0.9908674843743248 2.085826321115274 0.9993157294881337 0.009309036526366773 0.08287831367280692 0.03346917720359416 0.010213469910656189 0.05199904352710941 1.1180801613514341e-07 6.951527058359641 1.094958836740949 LGEINVIGEPFLNVNCEHIK(ub)SFDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGEINVIGEPFLNVNCEHIKSFDK 24 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 136677000.0 48715000.0 36125000.0 51837000.0 True False 63062527.81621123 34114611.99357282 42403197.892535746 1.0 0.5409648673297095 0.6723992735609201 25.91027966478813 -10.51256721169251 9.329868767831906 1.0000111444796693 0.6066820704453206 0.9227208644018041 0.05365787165202463 1.2438939627031464e-05 6.498800353984835e-07 0.05195547996065897 0.017318003608435537 3.07208189111262e-11 10.51256721169251 -0.3933290740343487 LGEIVTTIPTIGFNVETVEYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGEIVTTIPTIGFNVETVEYK 21 0 P84077;P61204;F5H423;F5H0C7;P18085;C9JPM4;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 25227100.0 13262000.0 2921600.0 9043500.0 False True 12841005.069251766 4088210.1159427282 6674736.050815418 1.0 0.3183715054931401 0.5197985683222185 23.614254791257228 -10.247066715875587 6.1029740792838325 1.0000147563941406 0.41908503690779175 0.9172864330993633 0.08223225405313296 1.6511166622204862e-05 2.0370742163229995e-06 0.07962305586943931 0.026540345872406106 5.661523106168395e-11 10.247066715875587 -0.5809297194863489 LGEIVTTIPTIGFNVETVEYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGEIVTTIPTIGFNVETVEYK 21 0 P84077;P61204;F5H423;F5H0C7;P18085;C9JPM4;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 203920000.0 47380000.0 101540000.0 55000000.0 False True 71878923.9419765 83419393.66435887 44129225.892643586 1.0 1.1605542917100191 0.6139383211727882 26.099065475463476 -6.828054725905378 1.336514483054435 1.0859134644202348 0.5997987352566883 0.9019373588207028 0.07183583024907331 0.18322609451376795 0.6407685057034802 0.04220875881657654 0.09714837113687864 1.4857484097675892e-07 6.828054725905378 -0.4861147291635466 LGEIVTTIPTIGFNVETVEYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGEIVTTIPTIGFNVETVEYK 21 0 P84077;P61204;F5H423;F5H0C7;P18085;C9JPM4;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 27757500.0 13262000.0 6151500.0 8344000.0 False True 11027940.606216282 6118360.648522846 10088691.821702981 1.0 0.5548053682002985 0.9148300831450017 23.394660066691504 -9.933241353939456 6.7222434457716345 1.0000000178868216 0.7348177256726472 0.41974300766672046 0.1469794744009256 3.938835900625668e-08 6.3092576829314985e-09 0.14231227475035066 0.04743742138242374 1.166161356785797e-10 9.933241353939456 -0.26518229221417433 LGEIVTTIPTIGFNVETVEYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGEIVTTIPTIGFNVETVEYK 21 0 P84077;P61204;F5H423;F5H0C7;P18085;C9JPM4;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 101025000.0 47380000.0 29885000.0 23760000.0 False True 61334343.99942705 28221873.478973694 19435923.79818757 1.0 0.4601316593397873 0.3168848402188687 25.870191797555925 -13.999999999999972 0.1862334702000299 3.857365998537456 0.21013063999313786 0.9994919280451064 0.006629870245987659 12.291798791732422 0.13684346256693794 12.729979515104661 0.10154576843609033 1.0000000000000655e-14 13.999999999999972 -3.647235358544318 LGEK(ub)DTSLYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGEKDTSLYR 10 1 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 17165200.0 6916500.0 7736600.0 2512100.0 True False 9067598.479481278 6582329.4370305985 2252171.989764746 1.0 0.7259176122460098 0.24837579595756248 23.112289078126043 -7.09971646191392 0.43057664465708334 1.0204278375288414 2.9716683918333337e-13 0.9997458325277864 0.004951364349809987 0.07631319306315594 0.022515385618691458 0.007102275800471474 0.038556742306590744 7.948469975759668e-08 7.09971646191392 -1.0204278375285443 down LGEK(ub)DTSLYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGEKDTSLYR 10 1 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 19836700.0 7883100.0 6969600.0 4984000.0 True False 7632855.3054907825 9752597.625983858 3678540.883204957 1.0 1.2777128919197793 0.4819350997730504 22.863791412031865 -6.812436367432367 1.4043560552696817 1.150918228233719 0.4672339101666987 0.8660806222816887 0.12068201490974452 0.20349138975285885 0.7905235319867094 0.06756315779192641 0.15611560155042242 1.5401521717030197e-07 6.812436367432367 -0.6836843180670202 down LGEK(ub)DTSLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGEKDTSLYR 10 1 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 17856900.0 6916500.0 8142000.0 2798400.0 True False 9473716.961384483 7782259.518006529 2137475.554857103 1.0 0.8214578870919989 0.22562163969744922 23.175499139648934 -6.949034349386883 0.5693448662447986 1.0074443112005902 0.010698594484618788 0.9991233194508964 0.009803047325739124 0.08387580114733108 0.03758488155270847 0.010393505028021876 0.04963692723617289 1.1245160297934634e-07 6.949034349386883 -0.9967457167159715 down LGEK(ub)DTSLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGEKDTSLYR 10 1 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 22578850.0 7883100.0 12529100.0 2166650.0 True False 6555146.930543183 12461603.251468362 2619686.4975422765 1.0 1.901041026770051 0.399638105034085 22.644196687466142 -6.744180153953798 1.6713221473937734 1.5335024487354505 0.39791831381174797 0.6235832476988006 0.3785644751118286 0.3103069563527935 1.7034364299032911 0.17907434004088305 0.43744415980786716 1.802269968491774e-07 6.744180153953798 -1.1355841349237026 LGEK(ub)DTSLYRPALEELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGEKDTSLYRPALEELR 17 2 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 89645000.0 31232000.0 40598000.0 17815000.0 True False 40945454.451118246 34540936.64976453 15971674.693546811 1.0 0.8435841563561202 0.3900719849773365 25.287199964555846 -6.952214917941951 0.5339746651943355 1.0069545732938951 0.20597338919588137 0.9993638316915542 0.006524052344232714 0.08260836018492697 0.032374526806664826 0.007236618248857193 0.03752321069886545 1.1163106859175251e-07 6.952214917941951 -0.8009811840980138 down LGEK(ub)DTSLYRPALEELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGEKDTSLYRPALEELR 17 2 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 135785000.0 48254000.0 60906000.0 26625000.0 True False 46722203.18290418 85226083.42059407 19651113.767121214 1.0 1.824102409874768 0.42059475856035033 25.47760497023827 -6.747581625788447 1.6589784975086863 1.4859789295922572 0.41833333849117943 0.6384728731583815 0.3462571327643196 0.30425608444973035 1.6468018553025643 0.16493873774121873 0.4014199385746264 1.7882094029851514e-07 6.747581625788447 -1.0676455911010778 LGEK(ub)DTSLYRPALEELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGEKDTSLYRPALEELR 17 2 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 127027000.0 63379000.0 38654000.0 24994000.0 True False 96150576.62554947 31755891.694919553 20053924.94474064 1.0 0.3302725039142539 0.20856791137965827 26.518792173802982 -13.999999999999998 0.2398356274776989 5.429427392399357 0.15467253098324307 0.9995246897329797 0.007586177845057306 13.617613303631686 0.15500128573590186 28.88578920070555 0.059526930892359935 1.0000000000000041e-14 13.999999999999998 -5.274754861416114 LGEK(ub)DTSLYRPALEELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGEKDTSLYRPALEELR 17 2 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 113444000.0 31232000.0 61476000.0 20736000.0 True False 42779314.41306444 58759787.04605373 15838583.871325366 1.0 1.3735560714855446 0.37023931048526565 25.350410026078738 -6.805854796934765 1.431649064893094 1.2046041262758982 0.35426193282111074 0.8488001222517965 0.16099317925087642 0.21249875530393947 0.859113594612966 0.08843798113410743 0.20500827509130104 1.5636703565742487e-07 6.805854796934765 -0.8503421934547875 down LGEK(ub)DTSLYRPALEELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGEKDTSLYRPALEELR 17 2 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 114669000.0 48254000.0 55738000.0 10677000.0 True False 40125339.01465547 55437728.33087316 12909511.335129773 1.0 1.381613954978049 0.32172965144081833 25.258010245672548 -6.809306874310859 1.417364882540567 1.208144638237403 0.3034644679688581 0.8580404401306015 0.16514404232499758 0.20773981075592024 0.8226463799679533 0.09161845397609707 0.212007530193234 1.5512904742097127e-07 6.809306874310859 -0.904680170268545 down LGEK(ub)DTSLYRPALEELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGEKDTSLYRPALEELR 17 2 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 117765000.0 63379000.0 36754000.0 17632000.0 True False 82045364.88686559 34708607.590637386 14423156.91959778 1.0 0.4230416628471085 0.17579490248457344 26.28991849589543 -9.824392674155874 0.2241681389043099 1.5443887708275945 3.625038457655001e-24 0.9992651613355883 0.00936139288203984 1.2748978088236926 0.09790710259904561 0.5693750565855142 0.1245229481254667 1.498329484799825e-10 9.824392674155874 -1.5443887708275945 LGEK(ub)DTSLYRPALEELRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGEKDTSLYRPALEELRR 18 3 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 47513800.0 16139500.0 21964700.0 9409600.0 True False 21159040.79514033 18687652.377730023 8435984.855256695 1.0 0.8831994114790913 0.3986941060765957 24.334770891310892 -6.9440404724566225 0.6208436939658826 1.0052997974893223 0.25088861336402235 0.9986465956138006 0.009577273828312825 0.08597091041978791 0.046573312732792645 0.00963763198106257 0.0410168599254941 1.137521273825627e-07 6.9440404724566225 -0.7544111841253 down LGEK(ub)DTSLYRPALEELRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGEKDTSLYRPALEELRR 18 3 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 64252800.0 24971900.0 24149000.0 15131900.0 True False 24179180.70342696 33791821.63537137 11168401.442730574 1.0 1.3975585876895322 0.46190156646406366 24.52726202479823 -6.791273566998905 1.491400810495685 1.2218266629765901 0.45162042447311723 0.8053808674079399 0.1691456209223661 0.23345602454112266 1.025829781802712 0.08926669244518827 0.20878850845383687 1.617061111703553e-07 6.791273566998905 -0.7702062385034729 down LGEK(ub)DTSLYRPALEELRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGEKDTSLYRPALEELRR 18 3 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 239406000.0 117554000.0 42563000.0 79289000.0 True False 178338012.34856704 34967300.10376312 63617494.39639672 1.0 0.19607317387511572 0.35672425389632806 27.410039002060792 -10.140619850252424 7.627074339960276 1.0000002018101368 0.2763987141958062 0.9643495997356843 0.06558552877983322 2.250281126633105e-07 2.524762015479388e-08 0.0635029326842621 0.02116763839304177 7.234027406016445e-11 10.140619850252424 -0.7236014876143306 LGEK(ub)DTSLYRPALEELRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGEKDTSLYRPALEELRR 18 3 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 64523600.0 16139500.0 38636000.0 9748100.0 True False 22106709.303587776 36928933.76783347 7445799.54842142 1.0 1.6704853382154052 0.33681175457502466 24.397980952833784 -6.770009488630645 1.5743098950574577 1.3845639306576252 0.3292878443443893 0.7306446935399138 0.28257833288458284 0.2664093690845471 1.303073086442424 0.14147842937970453 0.3367891796707344 1.6982065489953084e-07 6.770009488630645 -1.0552760863132358 LGEK(ub)DTSLYRPALEELRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGEKDTSLYRPALEELRR 18 3 Q13200;C9JPC0 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 260069000.0 117554000.0 71090000.0 71425000.0 True False 152175970.33576718 67133779.00686762 58426382.882388406 1.0 0.4411588692928387 0.3839396111848282 27.18116532415324 -13.999999999999998 0.3220540556801543 6.800491701413163 0.3728384216620022 0.9996981194295476 0.004828609830371238 18.17417254066243 0.18107524382605805 71.10770172613131 0.01889866093325295 1.0000000000000041e-14 13.999999999999998 -6.427653279751161 LGELPSWILMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGELPSWILMR 11 0 G3V325;C9JJT5;P56134-4;P56134-3;C9JU26;P56134-2;P56134 G3V325;C9JU26 ATP5J2-PTCD1;ATP5J2 ATP synthase subunit f, mitochondrial 0 2596220.0 662760.0 1144700.0 788760.0 False True 868884.77817697 973915.2220056525 707146.6815201793 1.0 1.1208795993055025 0.8138555298481144 19.728805350010454 -6.799889559861989 1.4562589673525874 1.0667040303398003 0.8096236688462886 0.8318706093061012 0.05178034939582397 0.22091386369047872 0.9249101728319536 0.027972172799310774 0.06506037615813795 1.58529627858747e-07 6.799889559861989 -0.25708036149351177 LGELPSWILMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGELPSWILMR 11 0 G3V325;C9JJT5;P56134-4;P56134-3;C9JU26;P56134-2;P56134 G3V325;C9JU26 ATP5J2-PTCD1;ATP5J2 ATP synthase subunit f, mitochondrial 0 3241060.0 662760.0 1191700.0 1386600.0 False True 907800.2824155543 1139046.7535750899 1059113.6379234062 1.0 1.254732759659663 1.1666813267618998 19.792015411533345 -10.071048373201597 4.226500144645115 0.9999755734790147 1.2107070431920617 0.8841957609333573 0.03594684710662138 12475193.109455649 0.023979367564503775 3031.846772646403 0.012305561891070163 8.490858956842215e-11 10.071048373201597 0.21073146971304701 LGELQGNHFTVVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGELQGNHFTVVLR 14 0 Q96PZ0;Q96PZ0-2;E7EUH7 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 17489600.0 4982400.0 7645600.0 4861600.0 False True 6531974.649630232 6504906.2823153855 4358568.267760154 1.0 0.9958560207645052 0.6672665620352473 22.639087761184634 -6.909651498252378 0.8981063454026132 1.010286252965509 0.6251171390364865 0.990789352128422 0.014960563157602092 0.10464888643460611 0.14002121603053128 0.012227347448572347 0.03367200124710655 1.2312564022633263e-07 6.909651498252378 -0.38516911392902253 LGELQGNHFTVVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGELQGNHFTVVLR 14 0 Q96PZ0;Q96PZ0-2;E7EUH7 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 15498100.0 5635400.0 4717200.0 5145500.0 False True 5456507.311662003 6600802.559873033 3797739.188308818 1.0 1.209712034246773 0.6960018508894952 22.379546352614845 -6.795895411224336 1.4728899275138954 1.1163165638600507 0.6896305010799997 0.8198053604513336 0.08952374113562951 0.22667360000989548 0.9712421346199541 0.04782902341955337 0.11150867755688809 1.5999432878543679e-07 6.795895411224336 -0.42668606278005106 LGELQGNHFTVVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGELQGNHFTVVLR 14 0 Q96PZ0;Q96PZ0-2;E7EUH7 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 59393000.0 16161000.0 26039000.0 17193000.0 False True 24517418.527359262 21392137.006364413 13794796.014040384 1.0 0.8725281163876485 0.5626528746754728 24.547303747896134 -6.956059667405037 0.48781173579456477 1.0069178208054606 0.4151718403421355 0.9995949750503441 0.0036959842554083783 0.08113998988684994 0.02657016512879378 0.004440700849122602 0.025557784475312845 1.106471756179393e-07 6.956059667405037 -0.591745980463325 LGELQGNHFTVVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGELQGNHFTVVLR 14 0 Q96PZ0;Q96PZ0-2;E7EUH7 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 19072500.0 4982400.0 7033500.0 7056600.0 False True 6824527.924297264 6722736.7133258255 5389976.415238928 1.0 0.9850845051700892 0.789794763099888 22.702297822707525 -6.922176121481901 0.8084338353658428 1.0039806413892591 0.7566716019625302 0.9947639700224051 0.006929944725042263 0.09690889550534644 0.09910709705288014 0.006040655269314466 0.018488527153183373 1.19625530989007e-07 6.922176121481901 -0.24730903942672888 LGELQGNHFTVVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGELQGNHFTVVLR 14 0 Q96PZ0;Q96PZ0-2;E7EUH7 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 11242100.0 5635400.0 2816800.0 2789900.0 False True 4686084.79054979 2801625.3393089757 3373255.190959871 1.0 0.5978605732783333 0.7198451034779735 22.15995162804912 -10.621007871272509 9.676674237984878 1.0000733767367727 0.6588528383781542 0.9124977789777089 0.04979997591704057 7.885113096486685e-05 3.088202467514164e-06 0.04822886140665326 0.01607287311401905 2.3932723796861613e-11 10.621007871272509 -0.34122053835861843 LGELQGNHFTVVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGELQGNHFTVVLR 14 0 Q96PZ0;Q96PZ0-2;E7EUH7 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 47784000.0 16161000.0 19541000.0 12082000.0 False True 20920733.080935843 18453526.172080453 9883199.971788812 1.0 0.8820688118666525 0.47241174262650215 24.318430069988583 -6.948117342654884 0.5791460366074217 1.0049126220604216 0.32933542564370144 0.9990451197796238 0.006986631831849775 0.08425069867760965 0.03916017501232632 0.007326944773311475 0.03421305654371401 1.1268929382036765e-07 6.948117342654884 -0.6755771964167202 down LGELSDK(ub)IGSTIDDTISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGELSDKIGSTIDDTISK 18 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 69697400.0 25347000.0 37778000.0 6572400.0 True False 33230162.46069717 32141669.65749065 5892351.0949125495 1.0 0.9672438314289336 0.1773193586363504 24.98599001052674 -6.9156197024237045 0.8565856969810066 1.0203291263381102 0.0619427201515381 0.9928750581319318 0.032103401855196646 0.10081819026850697 0.11947725608583498 0.027036878476691853 0.07788657895789057 1.214451841027926e-07 6.9156197024237045 -0.9583864061865721 down LGELSDK(ub)IGSTIDDTISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGELSDKIGSTIDDTISK 18 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 342017800.0 130303500.0 88687300.0 123027000.0 True False 126167086.71702984 124100601.38815956 90802537.9691124 1.0 0.9836210426772789 0.7197006789319484 26.910760361787432 -6.919576313082166 0.8278753468651986 1.0059126661027804 0.6775548705218468 0.9940621522516234 0.009897869276830845 0.09842165323562695 0.10691484903129711 0.008508939981815034 0.025385529086909848 1.203437906272788e-07 6.919576313082166 -0.3283577955809336 LGELSDK(ub)IGSTIDDTISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGELSDKIGSTIDDTISK 18 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 296333600.0 104597600.0 53039000.0 138697000.0 True False 158682206.30884945 43573776.05440156 111283477.15694547 1.0 0.2745977451913682 0.7012977683228706 27.241565120988323 -10.671612599530787 5.908426738995253 1.0058757238360234 0.48794775675940794 0.6575449902755985 0.1741995549843267 0.013550815350853096 0.0007531466207864557 0.16951809116805786 0.056222664614253376 2.1300382409279556e-11 10.671612599530787 -0.5179279670766155 LGELSDK(ub)IGSTIDDTISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGELSDKIGSTIDDTISK 18 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 123717300.0 25347000.0 63110300.0 35260000.0 True False 34718470.87691932 60321878.26814635 26932314.202494808 1.0 1.7374578068830806 0.7757344584089757 25.049200072049633 -6.701824791939797 1.8242381698798156 1.457112350376961 0.7784867207280032 0.42625893507959756 0.3111880195656048 0.3917610492897441 2.5358379462867413 0.13602040759974235 0.34903885361041115 1.986896332191779e-07 6.701824791939797 -0.6786256296489578 LGELSDK(ub)IGSTIDDTISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGELSDKIGSTIDDTISK 18 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 249887400.0 130303500.0 81838900.0 37745000.0 True False 108353133.67381278 81398017.60195026 45637304.986838356 1.0 0.7512290124159359 0.4211904486696739 26.691165637221708 -6.967217324735287 0.3177040733090418 1.046433893736844 0.11537619372454587 0.9999518265563777 0.0016454454085277315 0.07721637651909188 0.01224784370517553 0.005050123271674249 0.02909059670492537 1.0784069429740881e-07 6.967217324735287 -0.9310577000122982 down LGELSDK(ub)IGSTIDDTISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGELSDKIGSTIDDTISK 18 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 259861500.0 104597600.0 55686900.0 99577000.0 True False 135403655.12694126 52587875.06228075 81455007.74630149 1.0 0.388378548666057 0.6015717055048272 27.012691443080772 -10.093380330552439 5.129214546856727 1.0000112996754806 0.4949751270843709 0.8821032885473284 0.08703574182179658 1.1246717458493517e-05 1.9880531197844846e-06 0.08427387926132646 0.028090664882843404 8.065284089047186e-11 10.093380330552439 -0.5050361725911097 LGELTMQLHPVADSSPAGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGELTMQLHPVADSSPAGAK 20 0 F8W038;H0YIS7;Q8IXM2;Q8IXM2-3 F8W038 C17orf49;RNASEK-C17orf49;BAP18 Chromatin complexes subunit BAP18 0 11314800.0 2245900.0 3889400.0 5179500.0 False True 2944396.649326537 3309116.680762455 4643575.025272284 1.0 1.1238691911700618 1.577088815915612 21.48954060399023 -6.946925443046697 0.5916452345589318 0.9947864979148701 1.7290410606956104 0.9989373085986338 0.008086341334015076 0.084744513234093 0.041258060194333535 0.008369261489615396 0.03798727683314132 1.1299898876003169e-07 6.946925443046697 0.7342545627807403 LGELTMQLHPVADSSPAGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGELTMQLHPVADSSPAGAK 20 0 F8W038;H0YIS7;Q8IXM2;Q8IXM2-3 F8W038 C17orf49;RNASEK-C17orf49;BAP18 Chromatin complexes subunit BAP18 0 8091600.0 2245900.0 2542100.0 3303600.0 False True 3076269.923165387 2429781.6163994567 2523357.7197777014 1.0 0.7898466900132373 0.8202653807378658 21.55275066551312 -10.409124635521783 8.764595308362312 1.000001291594966 0.8050560354060742 0.9820665550242192 0.012418378486478572 3.1341836404072694e-07 2.1138057504468718e-08 0.012024122990138107 0.0040080144220859945 3.898300956627994e-11 10.409124635521783 -0.1949452561888919 LGEMWNNTAADDKQPYEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGEMWNNTAADDKQPYEK 18 1 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 22067400.0 5545700.0 2449700.0 14072000.0 False True 5369654.789062711 3427877.9850167395 10386121.049049009 1.0 0.6383795829852752 1.9342250958486542 22.356397910772095 -6.832226372502403 1.3179205532505769 0.8070555107665873 1.9707126780158943 0.9102633929621073 0.16355152421089927 0.17807398669152663 0.6041159655134398 0.09741400605721506 0.2241755851393432 1.4715452713675625e-07 6.832226372502403 1.163657167249307 LGEMWNNTAADDKQPYEKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGEMWNNTAADDKQPYEKK 19 2 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 1 10738300.0 5108500.0 3001400.0 2628400.0 True False 4946333.463751526 4199874.672094233 1939943.1896901939 1.0 0.8490884617610993 0.3921982219570882 22.237928073565516 -6.951245004304902 0.5450036974592323 1.0065139881017025 0.2134917520458484 0.9992954019202783 0.006859098476999045 0.08298962542631677 0.03392286812442363 0.00749343516557152 0.03786857291361248 1.1188065382313191e-07 6.951245004304902 -0.7930222360558541 down LGEMWSEQSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGEMWSEQSAK 11 0 P26583 P26583 HMGB2 High mobility group protein B2 0 16634450.0 882450.0 7260200.0 8491800.0 False True 1156900.4956579555 6177006.4600379495 7613149.995097447 1.0 5.339272031796431 6.580643731825593 20.141833353740058 -9.26068624283537 0.42594132545581836 9.089960762958976e-18 6.712974280052125 0.9978456011602332 0.11104624727224464 0.6446020621852229 0.1689015508157179 1.4033152295507392 0.29242608196410713 5.486732121409633e-10 9.26068624283537 6.712974280052125 LGEMWSEQSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGEMWSEQSAK 11 0 P26583 P26583 HMGB2 High mobility group protein B2 0 12995500.0 2758600.0 1773000.0 8463900.0 False True 2671029.7529813 2480968.146072854 6246950.678442708 1.0 0.928843320934068 2.3387798924628616 21.348964615772488 -6.895019522813584 0.9922425279631601 0.9331040250744638 2.472665118104445 0.9839205192633576 0.08223672845067091 0.11516389162127116 0.19882598775609037 0.06269761980559888 0.1594074464856146 1.2734458345963743e-07 6.895019522813584 1.5395610930299812 up LGEMWSEQSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGEMWSEQSAK 11 0 P26583 P26583 HMGB2 High mobility group protein B2 0 16040950.0 882450.0 5403000.0 9755500.0 False True 1208715.6123145714 5164277.594668298 7451451.8208292015 1.0 4.272533209676356 6.164768407814643 20.20504341526295 -8.488711012610738 0.3062133261231742 1.2108890192010634e-18 7.131100503302156 0.9986541406602051 0.07826801505023115 0.1702057491704666 0.08578913698432346 0.7262844743352732 0.5959057703185332 3.245555106082187e-09 8.488711012610738 7.131100503302156 LGETEK(ub)LSIMIEECGGLDKIEALQNHENESVYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGETEKLSIMIEECGGLDKIEALQNHENESVYK 33 2 P52292 P52292 KPNA2 Importin subunit alpha-1 1 98034600.0 33313600.0 40731000.0 23990000.0 True False 50539166.750389 33462234.817244463 19248365.984809488 1.0 0.662104996358827 0.3808603746847752 25.590898542681177 -7.473995498977533 0.21359834012537016 1.1762426461536104 3.9558628972263775e-17 0.9999398352879749 0.001963302225256872 0.12631025910961569 0.01919996599928307 0.02870489896026409 0.06320314166431848 3.357410938413348e-08 7.473995498977533 -1.1762426461536104 down LGETEK(ub)LSIMIEECGGLDKIEALQNHENESVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGETEKLSIMIEECGGLDKIEALQNHENESVYK 33 2 P52292 P52292 KPNA2 Importin subunit alpha-1 1 74566600.0 33313600.0 19195000.0 22058000.0 True False 43125111.90922996 18126781.376238924 18043670.33419283 1.0 0.4203300715924472 0.41840286402435956 25.362024864773627 LGETYKDHENIVIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGETYKDHENIVIAK 15 1 P07237;H7BZ94;H0Y3Z3 P07237 P4HB Protein disulfide-isomerase 0 14018150.0 4416200.0 788250.0 8813700.0 False True 4276010.148305665 1103002.3356694456 6505127.564667643 1.0 0.25795129043519727 1.5213077937257113 22.027833846351914 -6.747549757051751 1.6590921723780059 0.5623735563206853 1.5233265516081433 0.6382506010029876 0.31178326831381337 0.30435669513877595 1.6475612051398891 0.1485061284103202 0.36143982268797514 1.7883406274605914e-07 6.747549757051751 0.960952995287458 LGEWVGLCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGEWVGLCK 9 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 44886400.0 8010400.0 17296000.0 19580000.0 False True 10501711.972823944 14715504.219279947 17554049.42462232 1.0 1.401248125768479 1.6715416943492862 23.324121197186397 -8.055876027100103 0.08547925476437108 3.3935170127376074e-15 2.785499273183122 0.9999940774173465 0.0006713856772719898 0.10205421761814593 0.014893288843247462 0.22392560544576934 0.2442779123398436 8.792734767910143e-09 8.055876027100103 2.7854992731831185 LGEWVGLCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGEWVGLCK 9 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 16163500.0 9970800.0 2197400.0 3995300.0 False True 9654282.41173999 3074833.2792896177 2948811.0735691767 1.0 0.3184942337661988 0.3054407306319634 23.202737599137297 LGEWVGLCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGEWVGLCK 9 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 38108400.0 8010400.0 14152000.0 15946000.0 False True 10972061.352920443 13526717.845594259 12179883.21817873 1.0 1.2328328661773151 1.1100815814283431 23.38733125870929 -10.256304322385944 4.23902897530455 0.9998793275437912 1.1714572238085206 0.7223260839392533 0.05011300217010243 5.719150849360451e-05 1.0033591056763808e-05 0.04855578717434469 0.016173901900124184 5.5423720722066704e-11 10.256304322385944 0.1715778962647294 LGEWVGLCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGEWVGLCK 9 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 15116200.0 9970800.0 1971100.0 3174300.0 False True 8291161.981334753 1960481.2930672832 3838031.453695085 1.0 0.2364543471084948 0.4629063407922009 22.983142874571573 -10.27009940678149 5.072682000332803 1.0001289944330565 0.3496803439531652 0.9166398417433301 0.0924486392943168 0.0001348957129616362 1.9409741945433416e-05 0.08953055891090554 0.02983767003041927 5.369088878474508e-11 10.27009940678149 -0.6504486504798912 LGEYMEK(ub)LSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGEYMEKLSR 10 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 4359800.0 1040400.0 1479500.0 1839900.0 True False 1363974.4752479333 1258764.3670458307 1649524.7975670402 1.0 0.9228650461490651 1.209351661267123 20.37938521604859 -6.835033739587255 1.3053169573815404 0.9589055034579019 1.2178816048799346 0.9155616280756942 0.035171658641755324 0.1746819219219229 0.5802928753177771 0.02114435661355417 0.0486651216588674 1.4620635848529885e-07 6.835033739587255 0.25897610142203265 LGFAGLVQEISFGTTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGFAGLVQEISFGTTK 16 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 305103000.0 148640000.0 67806000.0 88657000.0 False True 143921504.5614226 94881289.4036187 65435072.04701084 1.0 0.6592572089400678 0.4546580599363076 27.100706932874008 -9.345877507161498 0.12199888334136112 1.6279872911516071 2.0697726082356567e-11 0.9999055509400192 0.0021860270775322186 0.7918210599428385 0.04535520406827791 0.37755004086937083 0.2091473724806072 4.5094387540933616e-10 9.345877507161498 -1.6279872911309095 LGFAGLVQEISFGTTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGFAGLVQEISFGTTK 16 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 240290000.0 51584000.0 111750000.0 76956000.0 False True 78256699.29554483 91807339.39326473 61745612.86898696 1.0 1.1731562948565522 0.789013763994799 26.22171092586385 -6.7841498752842595 1.5195717737655126 1.0975165724234128 0.7855578729489846 0.7818458651378254 0.07336675843820922 0.24417636327913558 1.113847907133812 0.038016702093541674 0.08940235380815939 1.6438043474607692e-07 6.7841498752842595 -0.3119586994744282 LGFAGLVQEISFGTTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGFAGLVQEISFGTTK 16 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 158302000.0 51584000.0 68507000.0 38211000.0 False True 66776504.87265606 64694525.22750717 31256990.077969097 1.0 0.9688216738938453 0.46808364914540995 25.9928372479563 -6.919613380608685 0.8275912426525359 1.011203291523676 0.3880494513786359 0.9940727700147574 0.01876452770405913 0.09839992983638574 0.10679781819223383 0.01613451577826952 0.04815320843137699 1.203335195866079e-07 6.919613380608685 -0.62315384014504 down LGFAGLVQEISFGTTK(ub)DK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGFAGLVQEISFGTTKDK 18 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 4427300.0 1846300.0 1362200.0 1218800.0 True False 1535280.2549583141 1354861.5582244694 1473645.4449055104 1.0 0.8824848452579471 0.9598543589330033 20.550070603117117 -10.021570078507132 4.647063554717945 1.0000022380390816 0.9211696020916813 0.5805651357698072 0.03158597170484188 7.32424888065764e-07 1.5416954087000105e-07 0.030583853747318028 0.010194328530385264 9.515462925722769e-11 10.021570078507132 -0.07883263594740031 LGFATSSDVIEMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGFATSSDVIEMK 13 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 5202300.0 1177900.0 1748600.0 2275800.0 False True 1544238.3067998262 1487715.6959894134 2040322.0470150933 1.0 0.9633977407751616 1.3212481765481632 20.558463975757267 -6.881681624132579 1.0703469612854908 0.9767664955096755 1.3474440659817666 0.9750179699771544 0.02540941691420197 0.12615223109184934 0.2633575740962298 0.018258090932073978 0.04434865568535317 1.313162209082832e-07 6.881681624132579 0.37067757047209104 LGFATSSDVIEMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGFATSSDVIEMK 13 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 5714400.0 1177900.0 2131500.0 2405000.0 False True 1613401.4615506083 2037323.2820720843 1836988.5325297767 1.0 1.2627503635171207 1.1385811754281439 20.621674037280158 -10.19722481997125 4.449209318847868 0.9999462038386815 1.2006657694766631 0.776896841628627 0.050691858779338496 5697458.035295655 13058111.561789904 1841.5611831540818 0.01735317183950938 6.350021270346208e-11 10.19722481997125 0.20071956563798166 LGFGSFVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGFGSFVDK 9 0 H7C580;V9GYZ1;V9GZ57;P18084 H7C580 ITGB5 Integrin beta;Integrin beta-5 0 8688800.0 1916800.0 2503400.0 4268600.0 False True 2512943.3623176026 2129902.478176772 3826926.2193025 1.0 0.8475728144594692 1.5228859817091362 21.26094672489438 -6.8474239342783285 1.2475972424390414 0.9188091945298973 1.5485493592926807 0.9364512184817839 0.07290224676152805 0.16031585514123164 0.4815040425494583 0.04575543232061209 0.10571246647450006 1.4209410657635903e-07 6.8474239342783285 0.6297401647627834 LGFGSFVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGFGSFVDK 9 0 H7C580;V9GYZ1;V9GZ57;P18084 H7C580 ITGB5 Integrin beta;Integrin beta-5 0 5603800.0 1916800.0 1739200.0 1947800.0 False True 2625492.7595722927 1662356.393234703 1487769.7562002095 1.0 0.6331597705512279 0.5666630581158317 21.324156786417273 -13.999999999999998 0.2401901492152853 3.4303704606673735 0.5373147294306052 0.9995252763018253 0.004151670158111875 13.630093585680497 0.15511364090450555 15.890521861770113 0.03245646255921565 1.0000000000000041e-14 13.999999999999998 -2.8930557312367684 LGFGTGVNVYLMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGFGTGVNVYLMK 13 0 Q96KB5;Q96KB5-2;E5RFX4;E5RIE1 Q96KB5 PBK Lymphokine-activated killer T-cell-originated protein kinase 0 8708800.0 3394700.0 2475600.0 2838500.0 False True 3286937.106664837 3464119.9900834486 2095011.6968252966 1.0 1.0539051638862644 0.6373750482104741 21.648312421005304 -6.874363083373733 1.110699681194464 1.0314632300759436 0.6108634940739148 0.9688497263874151 0.032644835726984206 0.1327431328498679 0.3034259183416177 0.022743196970766166 0.05429485835445165 1.335478549084811e-07 6.874363083373733 -0.4205997360020288 LGFGTGVNVYLMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LGFGTGVNVYLMK 13 0 Q96KB5;Q96KB5-2;E5RFX4;E5RIE1 Q96KB5 PBK Lymphokine-activated killer T-cell-originated protein kinase 0 78137500.0 23958400.0 28251000.0 25928100.0 False True 36346644.39365662 23209388.3239295 20803399.67031004 1.0 0.6385565630916978 0.5723609432825866 25.115318841558732 -13.999999999999998 0.2387319719543425 3.377795237507192 0.5427383338446008 0.9995228818062624 0.004105210800868808 13.57899916359717 0.15465016032482287 15.381407671443334 0.032588483350862577 1.0000000000000041e-14 13.999999999999998 -2.835056903662591 LGFGTGVNVYLMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGFGTGVNVYLMK 13 0 Q96KB5;Q96KB5-2;E5RFX4;E5RIE1 Q96KB5 PBK Lymphokine-activated killer T-cell-originated protein kinase 0 7015100.0 3394700.0 1621100.0 1999300.0 False True 2822843.46070898 1612366.8125368436 2417344.38628125 1.0 0.5711853437781083 0.8563508462045977 21.42871769643958 -10.185051272081589 5.340456021500221 1.0000127209691616 0.7137680949912818 0.5732558085397755 0.11641832886513322 1.7633605838478396e-05 2.6909608672273832e-06 0.11272657006248736 0.037573854073960446 6.530534496960752e-11 10.185051272081589 -0.2862446259778798 LGFGTGVNVYLMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LGFGTGVNVYLMK 13 0 Q96KB5;Q96KB5-2;E5RFX4;E5RIE1 Q96KB5 PBK Lymphokine-activated killer T-cell-originated protein kinase 0 65210100.0 23958400.0 22421800.0 18829900.0 False True 31014621.090668507 21174007.119653724 15403051.411089761 1.0 0.682710488635453 0.496638387619191 24.88644516365118 -10.135129481894188 0.1019654790815469 1.815890823913397 3.20128942295176e-11 0.9999211138076705 0.0018457238296260938 1.8004363822115004 0.04958026565256233 0.6458415061862108 0.27193614006398115 7.326060791428485e-11 10.135129481894188 -1.8158908238813842 LGFHLPLEVAYQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGFHLPLEVAYQR 13 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 31933900.0 6727900.0 14969000.0 10237000.0 False True 8820342.053076282 12735683.548704982 9177773.44023793 1.0 1.4438990542620895 1.0405235290208485 23.0724031739401 -10.489870544142452 6.682057726739971 0.9999054895373235 1.242211291641469 0.3246610645935193 0.16467736859469947 0.00023195019417518749 1.7707646256193655e-05 0.15951005370742088 0.0531493921720443 3.2369012911667055e-11 10.489870544142452 0.24230580210414543 LGFHLPLEVAYQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGFHLPLEVAYQR 13 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 18100800.0 8875900.0 3442300.0 5782600.0 False True 8594139.412922015 4816828.341357351 4267963.585718503 1.0 0.5604782643058877 0.49661325941504497 23.034921749822093 -13.999999999999998 0.27166498718692 4.422920544184227 0.4757538814816746 0.9995869186451705 0.004547983892783629 14.965265939889571 0.16501019940024564 28.31902523694264 0.026305564332551313 1.0000000000000041e-14 13.999999999999998 -3.9471666627025526 LGFHLPLEVAYQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGFHLPLEVAYQR 13 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 20055400.0 5447400.0 6200800.0 8407200.0 False True 8264104.058284564 5094218.79292847 6745513.234993331 1.0 0.6164272324017556 0.8162425336635395 22.97842698947898 -10.109016962106308 4.855215782149904 1.0000133934035857 0.7163348830307145 0.7287883658490854 0.0815742551553134 1.1826969846533068e-05 2.170500596293705e-06 0.07898765981137819 0.026327977640367414 7.780061640983964e-11 10.109016962106308 -0.2836785103728713 LGFHLPLEVAYQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGFHLPLEVAYQR 13 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 33345900.0 6727900.0 10733000.0 15885000.0 False True 9215386.444661126 10258780.57071531 12133290.161844302 1.0 1.1132230462954342 1.3166338964410598 23.13561323546299 -6.962087492392735 0.4049433938622799 0.989410037052786 1.4479338695722106 0.9998399504505453 0.0016572985424807868 0.07896371084010105 0.018436975142142063 0.0026169633213181235 0.017012145586412102 1.0912204784669754e-07 6.962087492392735 0.45852383251942463 LGFHLPLEVAYQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGFHLPLEVAYQR 13 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 20372500.0 8875900.0 4120500.0 7376100.0 False True 7380704.119040499 4098302.0486447862 8918408.406766934 1.0 0.5552725028052704 1.2083411369600248 22.81532702525637 -6.723361440731877 1.747340321928772 0.7304081052150835 1.2075126614077851 0.5282881967875047 0.18706978524590898 0.34882146497556565 2.0831649358014617 0.08495083642374357 0.21241018564068084 1.8907693745466884e-07 6.723361440731877 0.47710455619270165 LGFHLPLEVAYQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGFHLPLEVAYQR 13 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 21525300.0 5447400.0 9540700.0 6537200.0 False True 7051766.684307278 9009751.658050677 5347496.677336362 1.0 1.2776587855778923 0.7583201368866144 22.74955331157143 -6.761470851494523 1.606882209147991 1.160985717913603 0.7562807638729201 0.6969479928551102 0.11681018759635883 0.28046144416547175 1.427585258989121 0.05734615994300532 0.1376152728582739 1.7319252683289426e-07 6.761470851494523 -0.40470495404068285 LGFLGLLHMEVFNQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGFLGLLHMEVFNQR 15 0 Q8N442 Q8N442 GUF1 Translation factor GUF1, mitochondrial 0 17518100.0 5978400.0 5416800.0 6122900.0 False True 9069669.879584482 4450129.718348424 4912706.131237589 1.0 0.49066060589101645 0.5416631692732194 23.112618609410514 -10.595805667448289 10.0178207216377 1.000043206960289 0.5161618880959747 0.991735038927671 0.020821709310059194 2.0094809363595036e-05 8.107971540359265e-07 0.020162313620143344 0.006720177783119267 2.5362632713391257e-11 10.595805667448289 -0.4838813188643142 LGFLGLLHMEVFNQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGFLGLLHMEVFNQR 15 0 Q8N442 Q8N442 GUF1 Translation factor GUF1, mitochondrial 0 11448500.0 5978400.0 2319300.0 3150800.0 False True 7739156.651882125 2190228.9161714455 2577386.7299381094 1.0 0.2830061484333429 0.3330319886096764 22.883744931502964 -10.13012261993038 7.902844714620237 1.000000092382194 0.3080190685215098 0.9960955234846478 0.020422963731006605 3.324728297618136e-08 3.6539892039945994e-09 0.019774452254500575 0.006591483200865555 7.411009672189853e-11 10.13012261993038 -0.691981023860684 LGFMSAFVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGFMSAFVK 9 0 P36957;P36957-2;Q86SW4 P36957 DLST Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial 0 9918700.0 2597200.0 3543800.0 3777700.0 False True 3404954.3513205736 3015078.853624208 3386819.8422571896 1.0 0.8854975845578791 0.9946740815904476 21.699204026132772 -10.568803259097999 6.038482145488235 1.0001491954930228 0.9400858330741633 0.2865041511217773 0.0445711182723791 8.974641749412147e-05 6.408673624605999e-06 0.04326309155564587 0.014385266565897106 2.698961819440623e-11 10.568803259097999 -0.06006336241885957 LGFMSAFVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGFMSAFVK 9 0 P36957;P36957-2;Q86SW4 P36957 DLST Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial 0 8819900.0 4154800.0 1305800.0 3359300.0 False True 4022908.1482225354 1827212.749657043 2479398.553160197 1.0 0.45420195598161267 0.6163199510920189 21.939807367785697 -10.845337145990646 10.947522674523993 1.0094196347115265 0.5352609535368505 0.9163675019644916 0.06618439435725224 0.014696250498198005 0.00020762317514811564 0.061892794339562136 0.0213609214270385 1.4277851281064131e-11 10.845337145990646 -0.47415868117467597 LGFMSAFVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGFMSAFVK 9 0 P36957;P36957-2;Q86SW4 P36957 DLST Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial 0 3739300.0 1317100.0 0.0 2422200.0 False True 1998136.9929079206 0.0 1943451.108312026 1.0 0.0 0.9726315639067823 20.93022406747635 -11.919995354370972 17.38542220191488 0.8607311914815134 0.5376842037580728 0.0 0.48028443118846814 0.0 0.0 0.0 0.13689233771146936 1.202277295256133e-12 11.919995354370972 -0.32304698772344065 LGFMSAFVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGFMSAFVK 9 0 P36957;P36957-2;Q86SW4 P36957 DLST Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial 0 9715400.0 2597200.0 2568300.0 4549900.0 False True 3557455.0266909203 2454824.013767643 3475307.3281319053 1.0 0.6900506107173687 0.9769082959748819 21.762414087655664 -10.453833611927745 8.309035358647062 1.0000048233856944 0.8334794536163092 0.31001418928142266 0.11710915961280065 1.046426727067705e-05 6.877724450825791e-07 0.1133937400104813 0.03779681873906027 3.516951571165107e-11 10.453833611927745 -0.16652536976938526 LGFMSAFVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGFMSAFVK 9 0 P36957;P36957-2;Q86SW4 P36957 DLST Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial 0 8690500.0 4154800.0 2689300.0 1846400.0 False True 3454900.288848396 2674812.2071157456 2232473.703210976 1.0 0.7742082212182532 0.646176015677464 21.720212643219973 -13.999999989283888 0.0655040594290948 2.359191509314038 0.13519597722193713 0.9999388424272757 0.0011438989748150513 12.407041740578418 0.06753329073091258 2.6541452014108655 0.47419233339205513 1.000000024674761e-14 13.999999989283888 -2.223995532092101 LGFMSAFVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGFMSAFVK 9 0 P36957;P36957-2;Q86SW4 P36957 DLST Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial 0 10531500.0 1317100.0 5827000.0 3387400.0 False True 1705011.9139224442 5502722.327655335 2770927.9576591193 1.0 3.227380572958059 1.6251663317029235 20.7013503895688 -6.560963969134445 2.342701458530663 2.5337342524673314 1.6278002700006136 0.0 0.972283389228401 0.7584223212874371 7.802010163351899 0.3528439505126177 1.0932896665616008 2.748122139218104e-07 6.560963969134445 -0.9059339824667179 LGFSFVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGFSFVR 7 0 O60271-9;O60271-4;O60271;A0A087X2D8;O60271-2;E9PFH7;A0A087WYG2;A0A669KB35;Q9UPT6 O60271-9 SPAG9;MAPK8IP3 C-Jun-amino-terminal kinase-interacting protein 4;C-Jun-amino-terminal kinase-interacting protein 3 0 4397900.0 1352200.0 1128000.0 1917700.0 False True 1772747.2947234283 959706.7969095609 1719274.7998773379 1.0 0.5413669504763158 0.9698363692302614 20.75755546391763 -10.548007450540211 9.244511614911204 1.0000162049568406 0.7556016598532886 0.3025555880005659 0.17492190772234337 5.842625247076194e-05 2.8565264214832015e-06 0.1693786200572765 0.056455802957955534 2.8313434222626474e-11 10.548007450540211 -0.24441454510355198 LGFSFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGFSFVR 7 0 O60271-9;O60271-4;O60271;A0A087X2D8;O60271-2;E9PFH7;A0A087WYG2;A0A669KB35;Q9UPT6 O60271-9 SPAG9;MAPK8IP3 C-Jun-amino-terminal kinase-interacting protein 4;C-Jun-amino-terminal kinase-interacting protein 3 0 4001600.0 1352200.0 1333500.0 1315900.0 False True 1852144.8818309992 1274581.560705195 1005111.5218111989 1.0 0.6881651501502222 0.5426743510570095 20.82076552544052 -13.999999999999535 0.10188383407558654 2.531869016013712 0.24164928694912138 0.9997842474285986 0.002802193532052638 12.06632692621126 0.09543342698009183 3.8683104846387657 0.26819922312923233 1.0000000000010716e-14 13.999999999999535 -2.2902197290645905 LGFTVTVGNNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGFTVTVGNNR 11 0 A0A494C1B8;A0A494C0U1;Q5VZU9;P29144 A0A494C1B8 TPP2 Tripeptidyl-peptidase 2 0 23526800.0 10160000.0 5823300.0 7543500.0 False True 9837476.36130282 8148574.0581083335 5567631.049850852 1.0 0.8283195566458452 0.5659613141996417 23.22985683326352 -6.964946053622265 0.35897663422077997 1.022873351513209 0.3624310807136396 0.999912028528913 0.001674008295386773 0.07797926708295862 0.014924500583610924 0.0035273318179625387 0.022422498867761195 1.0840615635851063e-07 6.964946053622265 -0.6604422707995693 LGFTVTVGNNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGFTVTVGNNR 11 0 A0A494C1B8;A0A494C0U1;Q5VZU9;P29144 A0A494C1B8 TPP2 Tripeptidyl-peptidase 2 0 185037000.0 56843000.0 60068000.0 68126000.0 False True 86234986.77994452 49348396.08657394 54660866.23931348 1.0 0.5722549272547786 0.6338595073806614 26.361769974515095 -10.454012663487083 6.055869430253909 1.0001960197763737 0.6030572173177844 0.9822558141124139 0.025149964521135985 6.659270741412553e-05 6.00389068804518e-06 0.0243631906914666 0.008117116145672221 3.5155018961244163e-11 10.454012663487083 -0.39713880245858935 LGFTVTVGNNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGFTVTVGNNR 11 0 A0A494C1B8;A0A494C0U1;Q5VZU9;P29144 A0A494C1B8 TPP2 Tripeptidyl-peptidase 2 0 20710800.0 10160000.0 4576500.0 5974300.0 False True 8448490.1643159 4551845.486135879 7223498.507957821 1.0 0.538776207062609 0.8550046656227278 23.010262108697795 -10.110585132753636 5.464089209420923 1.0000041855974773 0.6968904363425658 0.5505618111660302 0.12909972760355426 6.58272752144606e-06 1.071785382170487e-06 0.12500200008990078 0.041666757917320656 7.752019691812704e-11 10.110585132753636 -0.3031137492549115 LGFTVTVGNNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGFTVTVGNNR 11 0 A0A494C1B8;A0A494C0U1;Q5VZU9;P29144 A0A494C1B8 TPP2 Tripeptidyl-peptidase 2 0 159788100.0 56843000.0 61220100.0 41725000.0 False True 73584384.04304418 57813147.6182071 34131478.134653896 1.0 0.7856714215938604 0.4638413241957455 26.132896296607544 -6.965239892577534 0.35391278892645694 1.0297337515281266 0.20885373805701624 0.9999180028455896 0.0019952891647793273 0.07787967078131235 0.014573553450151627 0.004375612525989939 0.02759189011410027 1.0833283473121382e-07 6.965239892577534 -0.8208800134711104 down LGGGLGGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGGGLGGTR 9 0 P08621-2;P08621;P08621-4 P08621-2 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 0 2953140.0 282840.0 1421300.0 1249000.0 False True 370805.97902645613 1209247.580184008 1119765.4612539983 1.0 3.2611329066453134 3.0198150099788594 18.500304981189558 -9.885602500873906 7.160565128319303 0.9999999780766582 3.140473958312094 0.9905572172648887 0.09851761877244254 3.537135098410752e-08 5.558151934967188e-09 0.09538927704621653 0.0317964247344693 1.3013601362361084e-10 9.885602500873906 2.140473980235436 LGGGLGGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGGGLGGTR 9 0 P08621-2;P08621;P08621-4 P08621-2 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 0 2267720.0 282840.0 929880.0 1055000.0 False True 387413.5914635995 888794.8268980476 805830.7284070343 1.0 2.2941756471173176 2.08002699482666 18.56351504271245 -10.153683507199146 4.690346983467588 0.9998726659695399 2.18710132098315 0.9761744027733182 0.08742582124116631 0.00011642925059417504 2.1007958765328757e-05 0.08465860250320123 0.028216562469198524 7.019666714040416e-11 10.153683507199146 1.1872286550136102 LGGHGPSFPLK(ub)GITEQQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGGHGPSFPLKGITEQQK 18 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 219292200.0 73589000.0 89696600.0 56006600.0 True False 96475891.6368896 76314216.91460843 50211574.285242796 1.0 0.7910185189252822 0.5204572192421525 26.523665136527427 -6.9675882919357095 0.3104424408168041 1.0414650407799222 0.26140491776714775 0.9999569864146841 0.0012874800527722362 0.07709335848042387 0.011817577263921367 0.0042722916090244985 0.024010396851876437 1.0774861788146326e-07 6.9675882919357095 -0.7800601230127744 LGGHGPSFPLK(ub)GITEQQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGGHGPSFPLKGITEQQK 18 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 373074200.0 103161800.0 145600000.0 124312400.0 True False 99886985.12691426 203738839.2939695 91751253.14793909 1.0 2.0396935500165845 0.9185506303084622 26.57379337710354 -6.663097791286171 1.9619417702184474 1.6675215022820242 0.9231979055725011 0.24886719294274107 0.4423516104048947 0.47712257239126515 3.5336865107504907 0.1819559339937642 0.49054053799241093 2.1722120008243565e-07 6.663097791286171 -0.7443235967095231 LGGHGPSFPLK(ub)GITEQQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGGHGPSFPLKGITEQQK 18 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 3549730000.0 259946000.0 726924000.0 2562860000.0 True False 394357086.598165 597198732.7168654 2056309597.6585596 1.0 1.5143603424715135 5.21433408334782 28.554927327243664 -6.932129056167357 0.7291038954177919 0.9479409405311287 6.016813114975482 0.9969403927315571 0.1038350161982287 0.09154731519973919 0.07237416010918565 0.0958262120859841 0.33095157213754706 1.1691519109295533e-07 6.932129056167357 5.068872174444354 up LGGHGPSFPLK(ub)GITEQQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGGHGPSFPLKGITEQQK 18 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 243803000.0 73589000.0 78957000.0 91257000.0 True False 100796841.96794939 75468418.66411716 69703976.09691054 1.0 0.748718086704681 0.6915293647699248 26.58687519805032 -13.999999999999998 0.20797849846839667 2.4413142953482945 0.6571776730838955 0.9994889749482025 0.0030288360277327658 12.700086891755612 0.14456093634381031 7.472728733401009 0.03436187784489437 1.0000000000000041e-14 13.999999999999998 -1.7841366222643988 LGGHGPSFPLK(ub)GITEQQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGGHGPSFPLKGITEQQK 18 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 335893100.0 103161800.0 160599000.0 72132300.0 True False 85783607.54263029 159733821.31059432 87214830.42792727 1.0 1.8620553027128681 1.0166841069791304 26.354198652537818 -10.22735466565079 4.232084937980103 0.9997689801575427 1.4393697048672567 0.26479622470523956 0.3451213455449404 243263484.62899044 234.89823207070046 559463.4796801725 0.11814421625785061 5.924413110553002e-11 10.22735466565079 0.439600724709714 LGGHGPSFPLK(ub)GITEQQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGGHGPSFPLKGITEQQK 18 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 2909456000.0 259946000.0 474030000.0 2175480000.0 True False 336505221.3017116 447649813.7941413 1779564962.309811 1.0 1.3302908408448648 5.2883725115048 28.326053649336114 -6.923413279875845 0.7990027497898115 0.9229379699231927 5.979604749616242 0.9950777688996276 0.13669559942184456 0.0962047859499492 0.09551044090114523 0.11995875499339553 0.3719471806226333 1.192852431404874e-07 6.923413279875845 5.05666677969305 up LGGIAYFLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGGIAYFLSR 10 0 Q9H2U1-3;Q9H2U1;Q9H2U1-2;E7EWK3 Q9H2U1-3 DHX36 ATP-dependent RNA helicase DHX36 0 8725300.0 2704400.0 3319100.0 2701800.0 False True 3545494.5894468566 2823903.2177504655 2422243.6534956377 1.0 0.7964765271834842 0.683189211656233 21.75755546391763 -13.999999999999444 0.06945790446006679 2.1832099249941983 0.26741870265155493 0.9999262412974518 0.0011256914760238612 12.365941611374353 0.07094505366927507 2.3788233903947757 0.38329404668098893 1.0000000000012802e-14 13.999999999999444 -1.9157912223426434 LGGIAYFLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGGIAYFLSR 10 0 Q9H2U1-3;Q9H2U1;Q9H2U1-2;E7EWK3 Q9H2U1-3 DHX36 ATP-dependent RNA helicase DHX36 0 5463100.0 3148300.0 0.0 2314800.0 False True 3048358.939792293 0.0 1708484.4374885322 1.0 0.0 0.5604603890921532 21.539601357381667 -9.931362028812108 5.985681067637223 1.0000002888467943 0.28023019454584985 0.6874077097072591 0.22880699572039143 8.820347130260204e-07 1.5718340306789368e-07 0.22154151010930087 0.07384714032661727 1.1712186281376458e-10 9.931362028812108 -0.7197700943009444 LGGIAYFLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGGIAYFLSR 10 0 Q9H2U1-3;Q9H2U1;Q9H2U1-2;E7EWK3 Q9H2U1-3 DHX36 ATP-dependent RNA helicase DHX36 0 9854400.0 2704400.0 2975100.0 4174900.0 False True 3704289.7636619983 2843650.2446599375 3188874.604764479 1.0 0.7676640938177451 0.8608599240929823 21.82076552544052 -10.132048936687239 5.3623894901774 1.0000041172672656 0.8142620089848913 0.8411687729539379 0.038047038388505774 1.8728271578867804e-06 3.0312789505433227e-07 0.036839702707741645 0.012279628837559304 7.37821087110673e-11 10.132048936687239 -0.18574210828237425 LGGIAYFLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGGIAYFLSR 10 0 Q9H2U1-3;Q9H2U1;Q9H2U1-2;E7EWK3 Q9H2U1-3 DHX36 ATP-dependent RNA helicase DHX36 0 6750900.0 3148300.0 1745200.0 1857400.0 False True 2617950.9433381665 1735798.2612049242 2245773.7523527225 1.0 0.6630369700478789 0.8578364533787335 21.320006632815943 -10.205221295150396 5.3512694611484815 1.0000133765850139 0.760436711713262 0.66849274669049 0.07952655605321993 1.2692285290977894e-05 1.8851584993832397e-06 0.07700555418980565 0.025667085597923602 6.234170917867922e-11 10.205221295150396 -0.2395766648717519 LGGIAYFLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGGIAYFLSR 10 0 Q9H2U1-3;Q9H2U1;Q9H2U1-2;E7EWK3 Q9H2U1-3 DHX36 ATP-dependent RNA helicase DHX36 0 15188400.0 1830100.0 8153600.0 5204700.0 False True 2369100.5266642384 7699844.992409566 4257498.004731778 1.0 3.250113241607003 1.7970947018978791 21.175907986240418 -10.299393384437167 6.120283346718627 0.99992148353683 2.5236039717524426 0.5944886856867354 0.5931923348485538 0.0006355527982169027 7.27532949497584e-05 0.5743848931917303 0.19145200283052774 5.018877730494443e-11 10.299393384437167 1.5236824882156126 LGGIGQFLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGGIGQFLAK 10 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 40696000.0 10226000.0 13661000.0 16809000.0 False True 13406385.028724872 11622832.05016092 15069765.92331341 1.0 0.8669624231481892 1.1240737820840245 23.676416937679903 -6.766085824419234 1.5895804654529933 0.9233122874606565 1.125306166272652 0.7153208710978811 0.056015912019117334 0.272801926590809 1.359760132783694 0.02778773185677793 0.06638283628548719 1.713618632109937e-07 6.766085824419234 0.2019938788119955 LGGIGQFLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGGIGQFLAK 10 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 21702200.0 6011700.0 2892500.0 12798000.0 False True 5820861.874138214 4047490.3341882285 9445819.868229745 1.0 0.6953421025451604 1.6227527937395372 22.472801352953617 -6.818202882379248 1.379648433568276 0.8354880384164836 1.6422269122748718 0.8801991259841788 0.1335915807178198 0.19582530261323547 0.7328973455229346 0.07610144656872946 0.17548980193053557 1.5198373658506923e-07 6.818202882379248 0.8067388738583883 LGGIGQFLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGGIGQFLAK 10 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 28846600.0 3197700.0 20471000.0 5177900.0 False True 4851144.683184014 16817790.10934698 4154485.795445805 1.0 3.4667673729963346 0.8563928859608941 22.209893777222057 -6.658952729572668 1.9766282698347293 2.589193502411006 0.8672981923152474 0.23116766239078013 1.0505565223512865 0.4869214686702255 3.6560457630590055 0.42956756465582596 1.1644479839718065 2.1930436223980297e-07 6.658952729572668 -1.7218953100957586 LGGIGQFLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGGIGQFLAK 10 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 35788000.0 10226000.0 14642000.0 10920000.0 False True 14006828.547259126 13995068.025380928 8340920.904459527 1.0 0.9991603722542531 0.5954896125355721 23.739626999202795 -6.90735412454096 0.9135690517649601 1.0135681829802743 0.5461707003032875 0.9898840838685052 0.019159128768087872 0.10619363637873493 0.14845230273420848 0.01548345610855604 0.041996723958997596 1.2377868811673024e-07 6.90735412454096 -0.4673974826769868 LGGIGQFLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGGIGQFLAK 10 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 15074800.0 6011700.0 4900700.0 4162400.0 False True 4998994.913466336 4874298.956387214 5032738.595236871 1.0 0.9750557943671407 1.0067500932396702 22.253206628387893 -6.6968433486625605 1.8417966012560218 0.9844627135972814 1.006651234265147 0.40263443353169504 0.010535536381217243 0.4021946582959734 2.650111133687739 0.004567003355028729 0.011792550748862273 2.0098176291965115e-07 6.6968433486625605 0.022188520667865586 LGGIGQFLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGGIGQFLAK 10 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 14578900.0 3197700.0 5784900.0 5596300.0 False True 4139485.6860905057 5462965.229664203 4577830.822887089 1.0 1.3197207682154455 1.105893623033777 21.981020099314506 -10.340630079706742 4.649189824785028 0.9998170003129015 1.212807195624944 0.5690850846592341 0.0872945664763253 0.00016572494087492548 2.3504103809751618e-05 0.08459495717035775 0.028174200181272473 4.564255213400906e-11 10.340630079706742 0.21299019531204244 LGGISSTEEMDLK(ub)VLQFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGGISSTEEMDLKVLQFK 18 1 O75150-3;O75150;H3BP71;O75150-4;H3BQ99;H3BUL6;I3L332 O75150-3 RNF40 E3 ubiquitin-protein ligase BRE1B 1 13103300.0 3972200.0 2613600.0 6517500.0 True False 3846104.685272347 3657224.109743942 4810371.229191076 1.0 0.9508904226523854 1.2507125059832966 21.87496660055837 -6.864864737230938 1.1608287673545268 0.9729221912972156 1.2666459103072503 0.9592885795345882 0.026492885214699075 0.1418785975566245 0.3605545490039908 0.01776095831874094 0.041716222594586884 1.365008207705455e-07 6.864864737230938 0.2937237190100347 LGGISSTEEMDLK(ub)VLQFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGGISSTEEMDLKVLQFK 18 1 O75150-3;O75150;H3BP71;O75150-4;H3BQ99;H3BUL6;I3L332 O75150-3 RNF40 E3 ubiquitin-protein ligase BRE1B 1 12068500.0 3972200.0 4247400.0 3848900.0 True False 3303060.2982968115 4224518.413157114 4653687.194697094 1.0 1.2789710243362624 1.4089016773616634 21.655371875992646 -12.645903720195607 0.11549839232793173 7.644741730320867e-15 1.6461103585304155 0.9997555340683393 0.0026672318958543997 7.365942844474153 0.09055152403071166 1.9111194618255205 0.19087433658067493 2.2599367255821726e-13 12.645903720195607 1.646110358530408 LGGISSTEEMDLK(ub)VLQFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGGISSTEEMDLKVLQFK 18 1 O75150-3;O75150;H3BP71;O75150-4;H3BQ99;H3BUL6;I3L332 O75150-3 RNF40 E3 ubiquitin-protein ligase BRE1B 1 28500200.0 4805400.0 6658800.0 17036000.0 True False 6220685.028595335 6288231.92644437 13935622.804121386 1.0 1.0108584340050228 2.24020710581904 22.568642029573898 -6.908833882731642 0.9036356796713683 0.9605189029168351 2.3951817764731116 0.9904741021016431 0.0568130545717193 0.10519430365809752 0.14298607857271978 0.046247066621552126 0.1266551420157651 1.2335765849908848e-07 6.908833882731642 1.4346628735562765 up LGGLTQAPGNPVLAVQINQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGGLTQAPGNPVLAVQINQDK 21 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 48407000.0 12444000.0 24024000.0 11939000.0 False True 16314204.50786744 20439712.844818532 10703666.806974774 1.0 1.2528783021545173 0.6560949264680963 23.959625306527343 -6.7915850036315275 1.4900448743051253 1.1410427373326848 0.649472325695818 0.8064041448621209 0.1076134627287667 0.23299675632035471 1.0219237538943038 0.0568423886067638 0.13292702818104182 1.6159019177486527e-07 6.7915850036315275 -0.49157041163686677 LGGLTQAPGNPVLAVQINQDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGGLTQAPGNPVLAVQINQDK 21 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 76713000.0 26849000.0 21412000.0 28452000.0 False True 25996693.191399597 29961923.262104906 20999567.658296064 1.0 1.152528248170314 0.8077784164196423 24.631824786704637 -6.786415737478098 1.5104130379950274 1.0856465326264932 0.8044545563443265 0.7895705483980195 0.06470519013530343 0.2407351245855823 1.0849607823334702 0.03372551816157135 0.07917784628436644 1.6352503942945908e-07 6.786415737478098 -0.28119197628216674 LGGLTQAPGNPVLAVQINQDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGGLTQAPGNPVLAVQINQDK 21 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 137595000.0 33461000.0 66323000.0 37811000.0 False True 50762783.32677244 54487142.46603588 30337639.276850004 1.0 1.073367906469762 0.5976354582757846 25.597267838623907 -6.8675313181374396 1.1470097664827401 1.0409386600394912 0.5710431953760211 0.9621600855382303 0.04068011307316302 0.1392474253958327 0.3439309707495732 0.027562813040007923 0.06499377719675807 1.3566526949155309e-07 6.8675313181374396 -0.4698954646634701 LGGLTQAPGNPVLAVQINQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGGLTQAPGNPVLAVQINQDK 21 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 69622000.0 12444000.0 19520000.0 37658000.0 False True 17044883.086455382 18657541.855992064 28763955.99085506 1.0 1.0946124864193507 1.6875419939789538 24.022835368050234 -6.934920630502456 0.7052317841378435 0.9924156758533339 1.826070489934213 0.9974200678299754 0.015454876787375277 0.0901619754075103 0.0657451489319261 0.014517878427000315 0.05227470123200258 1.161660893804204e-07 6.934920630502456 0.8336548140808792 LGGLTQAPGNPVLAVQINQDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGGLTQAPGNPVLAVQINQDK 21 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 56676000.0 26849000.0 15245000.0 14582000.0 False True 22326133.11237382 15162872.159104414 17631028.780449785 1.0 0.679153531997025 0.7897036487110315 24.412230062138914 -10.926721963768737 11.01157989660771 1.0414261300790666 0.7344285903542245 0.8849853586647861 0.04513189615907368 0.025252099542200517 0.00016804325994542916 0.02404125601787726 0.014566256850571236 1.1837991838832311e-11 10.926721963768737 -0.3069975397248421 LGGLTQAPGNPVLAVQINQDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGGLTQAPGNPVLAVQINQDK 21 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 92437000.0 33461000.0 37692000.0 21284000.0 False True 43315924.114918336 35594407.06606915 17410530.3922822 1.0 0.8217395286693229 0.401942951651951 25.368394160716356 -6.9567299125580115 0.4793100643355524 1.0101420248159765 0.19605865705688005 0.9996290044525643 0.004828892116567928 0.08089074209839281 0.02561044379995421 0.0059107488441844545 0.03463049306299809 1.1047654591928142e-07 6.9567299125580115 -0.8140833677590964 down LGGLTQAPGNPVLAVQINQDKNFAFLEFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGGLTQAPGNPVLAVQINQDKNFAFLEFR 29 1 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 375072000.0 99402000.0 110510000.0 165160000.0 False True 150800101.2596106 90788627.08142905 132516053.60780032 1.0 0.6020461944195348 0.8787530810716546 27.168062156450098 -10.112344398431148 5.5373070651572585 1.0000031556124453 0.7403996377455343 0.5399276229197545 0.11296511343551892 4.400834922931644e-06 7.055537095479423e-07 0.10937933055583172 0.03645933358648547 7.720680871092971e-11 10.112344398431148 -0.25960351786691105 LGGLTQAPGNPVLAVQINQDKNFAFLEFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGGLTQAPGNPVLAVQINQDKNFAFLEFR 29 1 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 219675000.0 99402000.0 19433000.0 100840000.0 False True 128677848.50635396 18351536.46702009 82488154.70577592 1.0 0.14261612763997925 0.641043937734961 26.939188478542548 -10.619189634293718 14.13405873325976 1.00000252132541 0.39183003285699314 0.665003747575371 0.2034823013909233 1.6167010055440597e-05 4.353718920598841e-07 0.1970217089070792 0.06567363037791704 2.4033131663369135e-11 10.619189634293718 -0.6081724884684169 LGGSAVISLEGKPL ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGGSAVISLEGKPL 14 1 P23528;E9PK25;G3V1A4 P23528 CFL1 Cofilin-1 0 188566000.0 54008000.0 81464000.0 53094000.0 False True 70805011.01421602 69309888.74418497 47600342.19361069 1.0 0.978883948344689 0.6722736358879124 26.077348130586685 -6.920828033600902 0.8185729555603724 1.0065654186027417 0.6218776587793775 0.994407606596185 0.011199613790988385 0.09768704696759634 0.10311121643560789 0.009692142933389707 0.029265924602568407 1.199974359657493e-07 6.920828033600902 -0.38468775982336423 LGGSAVISLEGKPL ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGGSAVISLEGKPL 14 1 P23528;E9PK25;G3V1A4 P23528 CFL1 Cofilin-1 0 441302000.0 185440000.0 86442000.0 169420000.0 False True 179553308.70472395 120958741.3890749 125043819.50894554 1.0 0.6736647865843117 0.6964161251663735 27.419836997497825 -10.633852718345668 6.522543330433778 1.0012883778900843 0.6850404558753427 0.9961017517207004 0.009288195081891257 0.0001746640903745375 9.804874128071794e-06 0.00902666214038855 0.0029977520723742106 2.3235246362816426e-11 10.633852718345668 -0.3162479220147416 LGGSAVISLEGKPL ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGGSAVISLEGKPL 14 1 P23528;E9PK25;G3V1A4 P23528 CFL1 Cofilin-1 0 1484770000.0 351130000.0 662940000.0 470700000.0 False True 532689881.0414996 544633177.4261383 377665938.6848608 1.0 1.0224207307285198 0.7089789990875356 28.988720634873307 -6.889718127082202 1.0240762830413637 1.0169556456183564 0.6821712641770514 0.980716270225743 0.019825456566396532 0.11937103837646464 0.22319953548137092 0.014756572269455034 0.03675029337863289 1.2890859439120782e-07 6.889718127082202 -0.33478438144130496 LGGSAVISLEGKPL ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGGSAVISLEGKPL 14 1 P23528;E9PK25;G3V1A4 P23528 CFL1 Cofilin-1 0 268828000.0 54008000.0 110460000.0 104360000.0 False True 73976217.11132126 105579511.95762727 79712317.36166629 1.0 1.4272088527958733 1.077539788790676 26.140558192109577 -10.168634575018146 5.971005472390118 0.999997258693094 1.2523743207932778 0.40987902332603643 0.14275179760823253 5.2094060638490626e-06 7.252459377699084e-07 0.13822033497532946 0.04607294456481968 6.782119301111787e-11 10.168634575018146 0.25237706210018385 LGGSAVISLEGKPL ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGGSAVISLEGKPL 14 1 P23528;E9PK25;G3V1A4 P23528 CFL1 Cofilin-1 0 337492000.0 185440000.0 69257000.0 82795000.0 False True 154201576.38491544 68883898.79456182 100107051.6991729 1.0 0.4467133242698827 0.6491960331798899 27.2002422729321 -10.104079674590098 5.1654054159335505 1.000010650997371 0.5479546787241716 0.8692038830530227 0.08266321976350104 1.0139575088747281e-05 1.7585756183894938e-06 0.08004020267617745 0.02667943945696767 7.869014134675369e-11 10.104079674590098 -0.4520559722731994 LGGSAVISLEGKPL ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGGSAVISLEGKPL 14 1 P23528;E9PK25;G3V1A4 P23528 CFL1 Cofilin-1 0 1173620000.0 351130000.0 516830000.0 305660000.0 False True 454544706.8070675 488067956.16991717 250033016.33644852 1.0 1.0737512699209115 0.5500735408246115 28.759846956965756 -6.871242189319473 1.1275767583167906 1.042036704380831 0.518681355874367 0.9659036161465673 0.04273725433204354 0.13566561910275748 0.32163386342158007 0.02939339489030581 0.06974031550895471 1.3451100287628545e-07 6.871242189319473 -0.5233553485064639 LGGSLADSYLDEGFLLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGGSLADSYLDEGFLLDK 18 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 12913300.0 3687100.0 2862400.0 6363800.0 False True 3570055.0287165036 4005371.2472188068 4696929.870092236 1.0 1.1219354365691128 1.3156463506336662 21.767514881406154 -6.964285850341446 0.37010906175378333 0.9851218931839122 1.459203780638187 0.9998976503293405 0.001314846293186482 0.07820419781712085 0.0157198998529616 0.002552831458542889 0.016450771508634367 1.0857107792707858e-07 6.964285850341446 0.4740818874542748 LGGSLADSYLDEGFLLDK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGGSLADSYLDEGFLLDKK 19 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 15040500.0 4827200.0 4708100.0 5505200.0 True False 4673963.178275692 6588068.882417153 4063222.967540118 1.0 1.4095251997358713 0.8693314030426557 22.156214937863332 -6.703912049226264 1.8163721335739875 1.2533003490528405 0.8707821776574481 0.4365005075675539 0.17274282877282993 0.3873928409807749 2.4872781245587814 0.07578590694632732 0.19400515098817275 1.97737004496182e-07 6.703912049226264 -0.38251817139539235 LGGSLADSYLDEGFLLDK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGGSLADSYLDEGFLLDKK 19 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 38144000.0 0.0 11916000.0 26228000.0 True False 0.0 9789496.699867066 21044024.30385925 0.0 LGGSLADSYLDEGFLLDK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGGSLADSYLDEGFLLDKK 19 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 14440400.0 4827200.0 4766400.0 4846800.0 True False 4014030.6812190716 4740722.45714367 5860243.470928811 1.0 1.181037922635883 1.4599398799684908 21.93662021329761 -6.96481012967057 0.3613004803343292 0.9763212474217391 1.6742334763869153 0.9999091716398413 0.0018029615998320398 0.07802550032227223 0.01508779325953822 0.00373219283052877 0.02380333022100959 1.084400902440837e-07 6.96481012967057 0.6979122289651762 LGGSLADSYLDEGFLLDK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGGSLADSYLDEGFLLDKK 19 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 31786400.0 0.0 9452400.0 22334000.0 True False 0.0 8926365.630672598 18269441.166191988 0.0 LGGSPTSLGTWGSWIGPDHDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGGSPTSLGTWGSWIGPDHDK 21 0 K7ELL7;P14314-2;P14314;A0A0C4DGP4 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 60766000.0 14585000.0 29231000.0 16950000.0 False True 19121076.241340898 24869848.74154555 15196176.595880909 1.0 1.3006510945119012 0.794734376040292 24.188660392778498 -6.745715033819793 1.6655709708162276 1.1776955161962586 0.7940422203828885 0.6303311439162422 0.12631871850923654 0.3076062409268024 1.6775165874512414 0.059944716625346096 0.14619785220364265 1.7959116436772492e-07 6.745715033819793 -0.38365329581337004 LGGSPTSLGTWGSWIGPDHDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGGSPTSLGTWGSWIGPDHDK 21 0 K7ELL7;P14314-2;P14314;A0A0C4DGP4 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 60223300.0 21755000.0 8145300.0 30323000.0 False True 21064399.43308492 11397760.767178373 22380496.629499197 1.0 0.5410911810415262 1.0624796923641289 24.328303448031882 -6.6743051375231035 1.9222347045932013 0.7081671054722138 1.0604101584795926 0.2981816820711848 0.19474405723157806 0.4513193526582597 3.2190152095143176 0.08144570738075879 0.21637856755651466 2.116873286632019e-07 6.6743051375231035 0.3522430530073788 LGGSPTSLGTWGSWIGPDHDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGGSPTSLGTWGSWIGPDHDK 21 0 K7ELL7;P14314-2;P14314;A0A0C4DGP4 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 61734000.0 14585000.0 21119000.0 26030000.0 False True 19977468.644804824 20185892.748806197 19882250.104677796 1.0 1.0104329586349057 0.995233703437608 24.25187045430139 -6.72200022957025 1.752451834598063 1.0063337895625113 0.9952552262055214 0.5218063895098894 0.004389179020256967 0.3514369398073294 2.110417627570138 0.0019880069281820473 0.004978312648538939 1.8967049186031091e-07 6.72200022957025 -0.011078563356989868 LGGSPTSLGTWGSWIGPDHDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGGSPTSLGTWGSWIGPDHDK 21 0 K7ELL7;P14314-2;P14314;A0A0C4DGP4 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 40589600.0 21755000.0 8328600.0 10506000.0 False True 18090246.409910664 8283732.17870234 12702756.025744442 1.0 0.45791151712362155 0.7021881149604071 24.108708723466158 -10.367909387270116 5.921341663950526 1.0000759229886262 0.5800498160420167 0.7975984849688447 0.09972550346719791 9.997225834451993e-05 1.0671799812576903e-05 0.09657615613562424 0.03218626784338373 4.286379435981448e-11 10.367909387270116 -0.4200261069466096 LGGSPTSLGTWGSWIGPDHDKFSAMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGGSPTSLGTWGSWIGPDHDKFSAMK 26 1 K7ELL7;P14314-2;P14314;A0A0C4DGP4 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 5070370.0 1301500.0 3072900.0 695970.0 False True 1706279.103743929 2614435.2980703847 623957.7006156491 1.0 1.5322436360697222 0.36568325735605445 20.702422223397072 -6.782666445809748 1.5255231086217238 1.3003320684168815 0.35566688975028754 0.7766760243178039 0.22534749450488242 0.2464662538283963 1.13308481013639 0.11632681152385987 0.2738723066712779 1.6494287273036348e-07 6.782666445809748 -0.944665178666594 down LGGSPTSLGTWGSWIGPDHDKFSAMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGGSPTSLGTWGSWIGPDHDKFSAMK 26 1 K7ELL7;P14314-2;P14314;A0A0C4DGP4 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 14064800.0 1301500.0 6628400.0 6134900.0 False True 1782699.7217150156 6335535.370812388 4685962.972231572 1.0 3.55389934358513 2.628576711575139 20.765632284919963 -10.183157470264478 5.954844833298511 0.9999714087732294 3.0912380275801588 0.8719621608274043 0.3777613826456864 0.00014339215082804715 1.966985190341014e-05 0.36577083216638895 0.12192196198557335 6.559073985812401e-11 10.183157470264478 2.0912666188069293 LGGSPTSLGTWGSWIGPDHDKFSAMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGGSPTSLGTWGSWIGPDHDKFSAMK 26 1 K7ELL7;P14314-2;P14314;A0A0C4DGP4 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 11325200.0 5574800.0 1526200.0 4224200.0 False True 4635693.205514602 1517978.057673018 5107460.689505956 1.0 0.3274543828455337 1.1017684870582336 22.144353659929013 -6.6770482460919816 1.91221932341255 0.573352080522841 1.0987674182993794 0.31071230635102975 0.2852263680226721 0.44512797914125124 3.144230044570029 0.11979645638561104 0.3171730015140836 2.103544742460275e-07 6.6770482460919816 0.5254153377765384 LGGTSLSLSVMEVNSGIYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGGTSLSLSVMEVNSGIYR 19 0 Q0VDF9 Q0VDF9 HSPA14 Heat shock 70 kDa protein 14 0 15058600.0 3886900.0 5956700.0 5215000.0 False True 5896711.470453124 4893680.3450904805 4184252.9641842996 1.0 0.8298999144881738 0.7095909279520449 22.491479173297435 -6.97485280109318 0.0813733852080522 1.4117059747443452 0.1247637526898691 0.9999998898541841 3.91161470587866e-05 0.07475706445033267 0.0023621948894981424 0.014168895848176639 0.023031749902317027 1.0596128073753141e-07 6.97485280109318 -1.2869422220544762 LGHAEQK(ub)DEMVPR ddPTM_RPMI8226_Bortezomib_1h_R1 2 LGHAEQKDEMVPR 13 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 11878420.0 2878380.0 5982080.0 3017960.0 True False 3773584.054271568 5089576.981965204 2705690.449516509 1.0 1.3487382045204417 0.7170081308918401 21.847503979037644 -6.75684275437786 1.624293666242347 1.2033613935725795 0.7150494912077642 0.6779524619894809 0.14662178454641817 0.2882637748271893 1.498174748948677 0.0712467558005729 0.17175937007387 1.7504803728221213e-07 6.75684275437786 -0.48831190236481536 LGHAEQK(ub)DEMVPR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LGHAEQKDEMVPR 13 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 10745380.0 2055080.0 2364600.0 6325700.0 True False 1989842.61029392 3308797.1112260995 4668809.403067738 1.0 1.6628436310032364 2.34632094966451 20.924222892390457 -6.970741029046566 0.23982715932967855 0.7540560110906162 3.2748729030925494 0.9999875993863379 0.0019355733602756861 0.07606296996007154 0.00816492421789538 0.016357688534007587 0.06665255687799043 1.0696925495908771e-07 6.970741029046566 2.520816892001933 LGHAEQK(ub)DEMVPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGHAEQKDEMVPR 13 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 24636000.0 3000400.0 4164700.0 17470900.0 True False 4551826.158621914 3421476.7460503816 14017768.957232498 1.0 0.7516712253102059 3.0795923369526137 22.118014029235095 -6.880509475029363 1.0769080961449926 0.8450125990844332 3.246221243860965 0.9740960157457328 0.1679959659815175 0.1271818213636412 0.26954218598431645 0.12010966217954831 0.2908465765046241 1.3167111856395096e-07 6.880509475029363 2.4012086447765317 up LGHAEQK(ub)DEMVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGHAEQKDEMVPR 13 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 2942520.0 823080.0 1367200.0 752240.0 True False 1127394.9189006493 1306792.5832741982 574576.4048691056 1.0 1.159125840790984 0.509649631408122 20.10456153979304 -6.841919912925839 1.273427542921015 1.0846420583796799 0.4874602980381718 0.9277073586203164 0.07431707849291434 0.16656918149799177 0.5238589340910721 0.045746252857853 0.10545226872685486 1.4390639276868077e-07 6.841919912925839 -0.597181760341508 LGHAEQK(ub)DEMVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LGHAEQKDEMVPR 13 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 13710880.0 2055080.0 7398100.0 4257700.0 True False 1708890.0754805454 7358244.966892124 5147965.384619461 1.0 4.305862075313979 3.0124613973030634 20.704628167824733 -9.326561307161183 10.622475946556145 1.000002297039749 3.6591617363085236 0.8493041854008088 0.528028615684432 0.0 0.0 0.5112615087159339 0.17042050290531127 4.714533139527196e-10 9.326561307161183 2.6591594392687745 LGHAEQK(ub)DEMVPR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LGHAEQKDEMVPR 13 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 44411700.0 4752100.0 8322900.0 31336700.0 True False 6151687.127895268 7859723.298582909 25633742.14169466 1.0 1.277653290093774 4.166945036176599 22.55255069965379 -6.9255546454776775 0.7824217094285177 0.9480786640707971 4.698105064991546 0.9955900670118508 0.09509277401961184 0.09501261700725051 0.08947637214756358 0.08444348796892617 0.26810434902903035 1.1869853381932258e-07 6.9255546454776775 3.750026400920749 up LGHGLLSGEYSK(ub)PVPESGDGERVPEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGHGLLSGEYSKPVPESGDGERVPEQK 27 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 12510100.0 3081600.0 2917100.0 6511400.0 True False 4040007.442256855 2481880.0507667405 5837662.789759239 1.0 0.614325613563795 1.444963375240261 21.945926519949058 -6.780428224950494 1.5339965844082168 0.7817455429800656 1.4516570510409557 0.768978033727399 0.16312898814867408 0.24990488409089162 1.1615323025216826 0.08375183592784965 0.19756553675803235 1.6579513207704105e-07 6.780428224950494 0.6699115080608901 LGHGLLSGEYSK(ub)PVPESGDGERVPEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGHGLLSGEYSKPVPESGDGERVPEQK 27 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 13871700.0 3250400.0 2990600.0 7630700.0 True False 3147217.8311790093 4184762.1757729705 5631990.753906917 1.0 1.3296703311461848 1.7895141220005935 21.585645605947718 -6.966436741041908 0.33247210238979563 0.9455669265718097 2.188726961160202 0.9999397714808549 0.0025127139947984816 0.0774767302415107 0.01315896101643719 0.006652029102392021 0.04002968527165518 1.0803469718260408e-07 6.966436741041908 1.2431600345883922 LGHGLLSGEYSK(ub)PVPESGDGERVPEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGHGLLSGEYSKPVPESGDGERVPEQK 27 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 81655900.0 11351300.0 29180000.0 41124600.0 True False 17220751.991189495 23972601.01561942 32996304.784447514 1.0 1.3920763174502666 1.9160780435911933 24.037644807542815 -6.967104288900288 0.3198841755299092 0.9281404795640625 2.3969124237504236 0.9999501828894399 0.002648750628280563 0.07725395375853863 0.012379260924038946 0.007946567969512281 0.04609711376559219 1.0786876614710648e-07 6.967104288900288 1.468771944186361 LGHGLLSGEYSK(ub)PVPESGDGERVPEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGHGLLSGEYSKPVPESGDGERVPEQK 27 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 101217300.0 11351300.0 27494000.0 62372000.0 True False 14694481.617574858 25963934.730831586 51020935.99076413 1.0 1.7669173643919678 3.4721154048566234 23.808771129635264 -6.957921805502881 0.4637945292344265 0.9521358563678218 4.356075976338069 0.9996851891870941 0.018331683407619818 0.08045200930477427 0.023938727346131707 0.023311536351707737 0.14081199165527902 1.1017376589808861e-07 6.957921805502881 3.403940119970247 LGHGLLSGQYSK(ub)PPVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGHGLLSGQYSKPPVK 16 1 Q92995;Q92995-2;H7C5J3 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 18959800.0 1697100.0 4668700.0 12594000.0 True False 2574624.7746291338 3835534.008280406 10104790.379853709 1.0 1.4897448537264626 3.924762349616274 21.29593075881345 -6.9399304572539116 0.6602092729281486 0.9726351311004354 4.580069851423129 0.9981547888182535 0.05494216438008868 0.08779835750939338 0.054754060846301376 0.05345395866947857 0.20964136057715163 1.1483374878645505e-07 6.9399304572539116 3.607434720322694 up LGHGLLSGQYSK(ub)PPVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGHGLLSGQYSKPPVK 16 1 Q92995;Q92995-2;H7C5J3 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 17687200.0 1697100.0 3613100.0 12377000.0 True False 2196929.4048422896 3412027.8088298435 10124512.998744432 1.0 1.553089417124344 4.608483539083604 21.0670570809059 -6.937607654116963 0.6814542638823602 0.9638722599198639 5.377506406276366 0.9978334937162268 0.07386055679315867 0.0888751456780611 0.05970759580292267 0.07065581945488182 0.26586206019137393 1.1544957696135728e-07 6.937607654116963 4.413634146356502 up LGHNAFSWVFSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGHNAFSWVFSR 12 0 Q5W0U4 Q5W0U4 BSPRY B box and SPRY domain-containing protein 0 11361400.0 3814800.0 3476600.0 4070000.0 False True 3693701.262115944 4864824.510229487 3003944.9026172124 1.0 1.3170595467817185 0.813261465789574 21.81663575857576 -6.736612865018404 1.6992403415225679 1.1893899660671907 0.8131882701349936 0.5895482849755336 0.13323001605873142 0.3239953219097362 1.8355468302568432 0.06206251480157911 0.15285734961545783 1.8339484962458332e-07 6.736612865018404 -0.3762016959321971 LGHNAFSWVFSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGHNAFSWVFSR 12 0 Q5W0U4 Q5W0U4 BSPRY B box and SPRY domain-containing protein 0 9868300.0 3814800.0 3525000.0 2528500.0 False True 3172175.224294517 3506010.1253422843 3057197.6595369135 1.0 1.1052384806775644 0.9637543462678124 21.597041034010036 -6.707548647398935 1.8040833259668514 1.06486025262307 0.9641121826204516 0.4533913736016082 0.04436433985579088 0.3800224623595721 2.4095335060340535 0.019581396277044867 0.04989176522614812 1.9608815154707573e-07 6.707548647398935 -0.10074807000261832 LGHPCFYHQK(ub)DIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGHPCFYHQKDIK 13 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 62655700.0 5570300.0 9363400.0 47722000.0 True False 8450552.343478087 7692428.113421889 38289725.782704346 1.0 0.9102870203932529 4.531032319118802 23.0106142109739 -6.901218644354776 0.9535253050260262 0.8544548910045365 4.920646950005368 0.987163086091695 0.19103394627691037 0.11051401657628179 0.1724012357054361 0.14990752119285133 0.39247613456235186 1.255397778035789e-07 6.901218644354776 4.066192059000832 up LGHPCFYHQK(ub)DIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGHPCFYHQKDIK 13 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 6921600.0 2424800.0 2454800.0 2042000.0 True False 3321314.0877561076 2346338.8190619554 1559721.6563101066 1.0 0.7064489407104375 0.4696098035593678 21.66332273041282 -7.229482397848401 0.1691550660710681 1.2301675826975882 8.398254589383327e-10 0.9999931375313871 0.0005682816164005117 0.09627792945316783 0.008418850411206212 0.017746505812824862 0.03995196435975764 5.895458711418282e-08 7.229482397848401 -1.2301675818577626 down LGHPCFYHQK(ub)DIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGHPCFYHQKDIK 13 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 54999800.0 5570300.0 5494500.0 43935000.0 True False 7210863.157028465 5188726.244946332 35939280.811168864 1.0 0.7195707548393641 4.98404698973363 22.781740533066348 -6.891187511606721 1.0153484086510665 0.7773446946683094 5.359456548435901 0.9816469443939344 0.26384313156183153 0.11818426479216201 0.21627030617479887 0.19768402124539297 0.4949756322410907 1.2847318425198467e-07 6.891187511606721 4.582111853767591 up LGHSFSLVGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGHSFSLVGNK 11 0 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 27516800.0 10778000.0 7843200.0 8895600.0 False True 14130062.37430049 6673025.132554139 7975168.644620553 1.0 0.4722573018991707 0.5644114253257403 23.752264498382708 -10.03679510497881 5.154694565147298 1.0000052205766372 0.5183343636107685 0.9732799498709666 0.03762176335432474 2.2571731057327736e-06 4.2174883377321517e-07 0.03642751020678309 0.012142371909625577 9.187659572051538e-11 10.03679510497881 -0.48167085696586875 LGHSFSLVGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGHSFSLVGNK 11 0 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 14397700.0 0.0 1827700.0 12570000.0 False True 0.0 2557510.141329589 9277539.908083145 0.0 LGHSFSLVGNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGHSFSLVGNK 11 0 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 20355400.0 6159800.0 9340600.0 4855000.0 False True 9344866.941700878 7673696.95155911 3895407.1219779025 1.0 0.8211670641682144 0.4168499290872612 23.15574269140965 -6.957578844668457 0.4683171540408742 1.0108556456139264 0.2106334204973164 0.9996695693670897 0.004434099052216332 0.08057772420562695 0.024415639167613815 0.0055728267523132485 0.033374669863200486 1.102608040982999e-07 6.957578844668457 -0.80022222511661 down LGHSFSLVGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGHSFSLVGNK 11 0 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 31386100.0 10778000.0 7792100.0 12816000.0 False True 14762917.864498239 7447819.256971105 9789124.753805256 1.0 0.5044950683415755 0.6630887500462272 23.8154745599056 -10.393001907149 5.0475848860630625 1.0003592825454881 0.5837919091938607 0.9017978108432184 0.0647455994344359 0.000261998464583722 3.150652144950819e-05 0.06274266520653882 0.020896552362461886 4.0457411505775456e-11 10.393001907149 -0.4165673733516274 LGHSFSLVGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGHSFSLVGNK 11 0 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 5145400.0 0.0 2631700.0 2513700.0 False True 0.0 2617522.5097484514 3039303.047964378 0.0 LGHSFSLVGNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGHSFSLVGNK 11 0 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 20492900.0 6159800.0 7804100.0 6529000.0 False True 7973982.527810709 7369794.9746447485 5340788.993197258 1.0 0.9242301383206263 0.6697768617588875 22.9268690135021 -6.948891768817062 0.570888401402025 1.0031571420534267 0.5784598056417899 0.9991113600615398 0.004210325268575134 0.08393399559243188 0.03782896690483472 0.004456074412958935 0.021205565708923492 1.1248852733943473e-07 6.948891768817062 -0.42469733641163676 LGHSFSLVGNK(ub)CYLFGGLANDSEDPKNNIPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGHSFSLVGNKCYLFGGLANDSEDPKNNIPR 31 2 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 43069000.0 11475000.0 12582000.0 19012000.0 True False 17408413.934870873 10336643.796385301 15254269.86674438 1.0 0.5937728638035153 0.8762584531718012 24.053281430524418 -10.10516069893214 5.580279431819439 1.000002690090339 0.7350156584876035 0.53985736909462 0.11532425894047302 3.85966507002709e-06 6.19022794244081e-07 0.11166336655851349 0.037220744524152194 7.849451331412757e-11 10.10516069893214 -0.2649870316027354 LGHSFSLVGNK(ub)CYLFGGLANDSEDPKNNIPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGHSFSLVGNKCYLFGGLANDSEDPKNNIPR 31 2 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 1 36131000.0 11475000.0 8885000.0 15771000.0 True False 14854613.706066417 8390541.939457288 12900839.824125288 1.0 0.564844169325703 0.8684735988022876 23.824407752616867 -10.121761468184408 5.667793787768689 1.0000029828726027 0.7166588840639647 0.5372730192917692 0.12395619551844271 4.6722873949966325e-06 7.240309850041205e-07 0.12002133358125211 0.040006690075164074 7.555070682847044e-11 10.121761468184408 -0.283344098808638 LGHTDILVGVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGHTDILVGVK 11 0 Q15024 Q15024 EXOSC7 Exosome complex component RRP42 0 26038900.0 3588100.0 14597000.0 7853800.0 False True 5443410.025247075 11992051.303118452 6301492.987557169 1.0 2.2030402353484546 1.1576370250137726 22.37607928058672 -6.612172435752261 2.1462153851119186 1.8025833387787686 1.16146821166458 0.05712169795558508 0.5183847387422383 0.6065726083783018 5.297997265839041 0.19926534234674573 0.5751434921648986 2.442460586072224e-07 6.612172435752261 -0.6411151271141886 LGHTDILVGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGHTDILVGVK 11 0 Q15024 Q15024 EXOSC7 Exosome complex component RRP42 0 16120100.0 3588100.0 8025400.0 4506600.0 False True 4644866.182025003 7578779.435106414 3686445.04162088 1.0 1.6316464539786428 0.7936601178925063 22.14720560267917 -6.7050591331637825 1.812843114105135 1.390265577381506 0.795902745132866 0.441621880307721 0.26638707186698174 0.38508313442849446 2.4637323095807315 0.1170775350523902 0.2992247519463891 1.972154191011423e-07 6.7050591331637825 -0.5943628322486401 LGHVVMGNNAVSPYQQVIEK(ub)TK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGHVVMGNNAVSPYQQVIEKTK 22 1 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 44263300.0 7801300.0 11362000.0 25100000.0 True False 7553652.001715728 15898905.85204725 18525557.016140535 1.0 2.104797235620067 2.4525298507175948 22.848742889379242 -10.223048549503867 0.26544239224902033 6.44320074154014e-12 2.6148664610914203 0.9990631880394051 0.018953904017587744 1.7279460552730024 0.12479133588202591 1.3710137255188886 0.1450962896355152 5.983447027477661e-11 10.223048549503867 2.614866461084977 LGHVVMGNNAVSPYQQVIEK(ub)TK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGHVVMGNNAVSPYQQVIEKTK 22 1 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 126456000.0 19520000.0 22376000.0 84560000.0 True False 29613267.103152853 18382827.975514017 67846678.9360354 1.0 0.6207632515345408 2.2910906351434597 24.819740329786132 -6.847044000245512 1.249391411468361 0.7980376987915936 2.3541067206483732 0.9358741283087141 0.18105424729856406 0.16074090393115592 0.4843517934907888 0.11348051470570741 0.262133796063399 1.4221846921635695e-07 6.847044000245512 1.5560690218567796 up LGICVTQFDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGICVTQFDPK 11 0 C9J8T0;P57772;P57772-2 C9J8T0 EEFSEC Selenocysteine-specific elongation factor 0 7810400.0 2346500.0 1860400.0 3603500.0 False True 3214064.4617781662 1778201.3764798993 2752427.516412078 1.0 0.5532562889221324 0.8563697303349387 21.615967433544114 -9.962198279813801 5.454914461097455 1.0000006441360443 0.7048130096278576 0.558403648788236 0.12374554427578094 2034704286315.0972 386795496311.17 17056930.598308478 0.04238785877672969 1.0909421463924056e-10 9.962198279813801 -0.29518763450818664 LGIEGLSLHNVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGIEGLSLHNVLK 13 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 6908000.0 0.0 3784100.0 3123900.0 False True 0.0 3219527.03030627 2800668.794564747 0.0 LGIEGLSLHNVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGIEGLSLHNVLK 13 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 12259900.0 4819600.0 3623400.0 3816900.0 False True 4666604.436115662 5070242.515781385 2817139.3854544545 1.0 1.0864950276354897 0.6036807756089468 22.153941752023634 -6.86057843918026 1.182901362659229 1.04699744266335 0.5800509920806137 0.9543348517039697 0.044918690620966616 0.14620120176996543 0.3884130319406623 0.029611810210190083 0.0691641439907289 1.3785469471384783e-07 6.86057843918026 -0.4669464505827362 LGIEGLSLHNVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGIEGLSLHNVLK 13 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 16817200.0 0.0 4570200.0 12247000.0 False True 0.0 4368273.452369619 9354510.834882412 0.0 LGIEGLSLHNVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGIEGLSLHNVLK 13 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 8447300.0 4819600.0 1288000.0 2339700.0 False True 4007710.944481984 1281061.288352016 2828920.4524494796 1.0 0.3196491229278511 0.7058693832060114 21.93434702745791 -10.739889386431862 6.965335852698367 1.0075159834986693 0.5127592530674704 0.6796977446730539 0.1576737610010672 0.018419123429955116 0.000687835135796821 0.15280052638437938 0.050888987540918466 1.8201643902657135e-11 10.739889386431862 -0.49475673043119894 LGIEK(ub)TDPTTLTDEEINR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGIEKTDPTTLTDEEINR 18 1 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 1 33552500.0 5765600.0 8737900.0 19049000.0 True False 7463682.856967005 8251628.1837685825 15582277.459245594 1.0 1.105570579819863 2.0877464594707766 22.831456254549 -6.927400301857292 0.7678242501819864 0.983536928437507 2.2766570431097652 0.9960024265239683 0.030967346033056623 0.09400977544339421 0.08445671014055904 0.027788412561017505 0.09017324023045513 1.1819516143019293e-07 6.927400301857292 1.2931201146722584 up LGIGMDTCVIPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGIGMDTCVIPLR 13 0 P49903-4;P49903;Q5T5U6;P49903-2 P49903-4 SEPHS1 Selenide, water dikinase 1 0 5645010.0 989610.0 2211200.0 2444200.0 False True 1297388.293396873 1881297.5791900905 2191297.630421958 1.0 1.4500651722888631 1.689006785073277 20.30717889557582 -10.523801078856954 0.12412490795723441 2.1820649742933807e-20 2.1472498097091512 0.9998169689546226 0.003864574493837551 2.4152956362719764 0.06689697376885438 1.010476827614566 0.28436239800595325 2.9936355060612226e-11 10.523801078856954 2.1472498097091512 LGIGMDTCVIPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGIGMDTCVIPLR 13 0 P49903-4;P49903;Q5T5U6;P49903-2 P49903-4 SEPHS1 Selenide, water dikinase 1 0 5343110.0 989610.0 1864300.0 2489200.0 False True 1355495.5602046847 1781929.0615843234 1901302.2266832103 1.0 1.314596014844376 1.4026620835232444 20.37038895709871 -12.688876322140981 0.19707198078097876 9.777848854174707e-10 1.4651965045329418 0.9994377065717558 0.004098504060750246 7.214277448629165 0.1312688756043325 2.886763127521179 0.057174599423057526 2.0470275037514986e-13 12.688876322140981 1.4651965035551568 LGIHEDSQNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGIHEDSQNR 10 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 66477400.0 1883400.0 35460000.0 29134000.0 False True 2469155.638871546 30169506.22199737 26119493.153061636 1.0 12.218551859203757 10.578309743568362 21.23558634640887 -9.91838794289012 8.856936935669502 1.0001137462490788 11.398430792312517 0.9816805777908008 0.6696260428753924 3.117073107057045e-08 8.726589151707473e-09 0.6483626362659107 0.21612087553521825 1.206735411145993e-10 9.91838794289012 10.398317046063438 LGIHEDSQNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGIHEDSQNR 10 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 47353100.0 18436000.0 5644100.0 23273000.0 False True 17850759.271356184 7897818.563592662 17177103.1249657 1.0 0.4424360019389045 0.9622617651075801 24.08948210394064 -10.629231626121113 9.604283940627962 1.000081798017305 0.7023488835232425 0.3041821543083062 0.21221797915268475 0.0003718005018580961 1.4353034524869184e-05 0.2055349678581995 0.06849305825201175 2.3483800044907182e-11 10.629231626121113 -0.29773291449406236 LGIHEDSQNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGIHEDSQNR 10 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 132752690.0 893290.0 130850000.0 1009400.0 False True 1355186.2382466898 107498795.16428365 809891.6475642633 1.0 79.32400147699495 0.5976238724295808 20.37005969878663 -13.997900969975763 8.677855378517511e-12 8.886292769798922 63.24316874447405 0.0 38.11743047096227 0.0 0.2754658881854852 494269078.1175182 494269051.8227874 1.0048448939715042e-14 13.997900969975763 54.35687597467513 LGIHEDSQNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGIHEDSQNR 10 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 54279400.0 1883400.0 29680000.0 22716000.0 False True 2579743.8769712346 28368639.461364996 17350948.65070538 1.0 10.99668835910617 6.725841586675796 21.29879640793176 -9.486530608180423 9.04004943728254 1.0000000012475858 8.86126497089448 0.8187576293920795 1.7435658936779237 0.0 0.0 1.68820041730741 0.5627334724358032 3.26189060451114e-10 9.486530608180423 7.861264969646894 LGIHEDSQNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGIHEDSQNR 10 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 20223030.0 18436000.0 1200300.0 586730.0 False True 15330350.853280311 1193833.7456591043 709412.5302669926 1.0 0.07787386975580235 0.04627503551982935 23.869887379374916 LGIHEDSQNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGIHEDSQNR 10 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 5008090.0 893290.0 2024000.0 2090800.0 False True 1156381.5143783912 1911362.6207610087 1710295.8534196385 1.0 1.6528823722925516 1.4790065667376238 20.14118602087908 -10.064187911378287 4.448002538234728 0.9999615749392655 1.5659444695536104 0.9338870848440929 0.0709845005235537 24618073.119249873 0.5729304863660581 9815.55562717797 0.024299882583539444 8.626052333051203e-11 10.064187911378287 0.5659828946143449 LGIHEDSQNRK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGIHEDSQNRK 11 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 5092660.0 1503400.0 930660.0 2658600.0 False True 1455675.3899195527 1302277.3913277844 1962232.9037096128 1.0 0.8946207378004475 1.3479879630430893 20.47325724521418 -6.8454959401777575 1.2566349612101686 0.9439145746399515 1.3645966971169674 0.9334955211603312 0.049957061771857436 0.16247652172399193 0.49600420814218044 0.031141100565191596 0.07188474942186546 1.427263172281662e-07 6.8454959401777575 0.42068212247701586 LGIHEDSTNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGIHEDSTNR 10 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 108394600.0 5042600.0 49017000.0 54335000.0 False True 6610897.4326078715 41703854.666769534 48712935.41812332 1.0 6.308349976974029 7.368581333277017 22.656414700919377 -9.42214540333082 0.5009010600415251 4.272842813173292e-20 7.362543548067066 0.9981975010432126 0.11828650591562574 0.7614844710112455 0.21261921597822472 1.728541273945879 0.21344113884480923 3.783159020073731e-10 9.42214540333082 7.362543548067066 LGIHEDSTNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGIHEDSTNR 10 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 86049400.0 30263000.0 8861400.0 46925000.0 False True 29302317.630128656 12399803.231590519 34633934.780175075 1.0 0.4231680028900184 1.1819520632239837 24.804511441530032 -6.703440954010146 1.8184016994841519 0.6430316026593238 1.1798623259034657 0.4340269866016754 0.24333729100765436 0.3883997495502169 2.4990849479241555 0.10665859241026826 0.27315869617753447 1.97951613482125e-07 6.703440954010146 0.5368307232441419 LGIHEDSTNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGIHEDSTNR 10 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 341991600.0 3961600.0 338030000.0 0.0 False True 6010036.831754635 277705905.4595557 0.0 1.0 46.207022225266336 0.0 22.518942401662787 -4.243517026908073 8.100242902885253 9.999999999999986 17.330941828999634 0.0 22.300586378097265 0.0 0.0 7.775992838863598 0.0 5.7079869705384905e-05 4.243517026908073 7.330941828999649 LGIHEDSTNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGIHEDSTNR 10 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 99901600.0 5042600.0 47611000.0 47248000.0 False True 6906985.491141103 45507388.59147735 36088995.50310477 1.0 6.588603472505496 5.2249994660322505 22.71962476244227 -9.566331658788881 7.259528816787415 0.999987835582454 5.906801469271234 0.945249596040819 0.5566890045652061 0.0 0.0 0.5390118109006372 0.17967060363354573 2.714365590551846e-10 9.566331658788881 4.90681363368878 LGIHEDSTNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGIHEDSTNR 10 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 34566000.0 30263000.0 2837300.0 1465700.0 False True 25165025.378217716 2822014.9017400453 1772171.0933688935 1.0 0.1121403558838736 0.07042198713230169 24.584916716964308 -13.219628244444861 0.4441647656263255 9.999999999953756 0.07020767912233242 0.999880013314539 0.00469604715596094 16.735128193703613 0.22515910634929515 143.79894327861498 0.009547591890616639 6.030755971775994e-14 13.219628244444861 -9.929792320831424 LGIHEDSTNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGIHEDSTNR 10 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 17029200.0 3961600.0 7006800.0 6060800.0 False True 5128369.294810694 6616865.420527785 4957796.589059571 1.0 1.2902474529717027 0.9667393871335042 22.290068723755237 -6.6702634328600245 1.9366846666994302 1.1852269475275394 0.9680535066108789 0.2800743247495907 0.12328429150193206 0.46053443052522985 3.330494097831109 0.051246028396805504 0.13685729487554307 2.1366656450134812e-07 6.6702634328600245 -0.21717344091666058 LGIHEDSTNRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGIHEDSTNRR 11 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 14099340.0 278440.0 7824300.0 5996600.0 False True 365037.53641679604 6656944.938882525 5376129.355448943 1.0 18.23632989699365 14.72760694207221 18.47768529683492 -10.078855716975811 12.72196193696304 0.9999935606359285 16.48196841868995 0.9629070452698187 1.4324301480628157 0.0 0.0 1.3869445270109975 0.46231484233699904 8.339581994809873e-11 10.078855716975811 15.48197485805402 LGIHEDSTNRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGIHEDSTNRR 11 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 10138330.0 3383400.0 914530.0 5840400.0 False True 3275995.8189795273 1279706.5982109455 4310624.031755666 1.0 0.39063132828099095 1.3158209808394767 21.643502085051157 -6.729073958462421 1.7268012301565518 0.632905370758243 1.3151591135936593 0.554902690965176 0.25618264368236554 0.337966007208203 1.9739093826106129 0.11759259958704558 0.2920828211328211 1.866061881547878e-07 6.729073958462421 0.6822537428354163 LGIHEDSTNRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGIHEDSTNRR 11 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 15134140.0 278440.0 8024300.0 6831400.0 False True 381386.792558071 7669759.893188387 5217964.0170993395 1.0 20.110187460203065 13.681554051992604 18.54089535835781 -8.994389804382187 10.830929944819077 1.000000000009005 16.89587075615225 0.8907355856518274 2.624478599030962 0.0 0.0 2.5411404765814787 0.8470468255271594 1.0130017499912344e-09 8.994389804382187 15.895870756143244 LGINLLGGPLGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGINLLGGPLGGK 13 0 Q8TD19 Q8TD19 NEK9 Serine/threonine-protein kinase Nek9 0 3409300.0 1060200.0 1152400.0 1196700.0 False True 1389932.4669914045 980466.412020016 1072876.9635569723 1.0 0.70540579150748 0.7718914328832691 20.40658335737837 -9.891949959775104 5.186142184009031 1.0000004685109602 0.7386486121906591 0.9537103513737939 0.02714264944851176 1.470345944831598e-07 3.141293033749744e-08 0.026280804307270006 0.00876025243813569 1.282478343703762e-10 9.891949959775104 -0.2613518563203011 LGINLLGGPLGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGINLLGGPLGGK 13 0 Q8TD19 Q8TD19 NEK9 Serine/threonine-protein kinase Nek9 0 5427400.0 1060200.0 1980600.0 2386600.0 False True 1452184.5908277058 1893090.5430316548 1822934.233569882 1.0 1.3036156388029463 1.2553047629646443 20.46979341890126 -10.065798074460016 4.358009720199017 0.9999769450904555 1.2794602009187828 0.9780777772873802 0.0197228325888756 2931454.544551644 3385425.1297240607 524.9511823736669 0.006751649828993457 8.594130133412119e-11 10.065798074460016 0.2794832558283272 LGINSLQELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGINSLQELK 10 0 P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;H0YC42;E5RFR7;H0YC44;P55327-8 P55327-2 TPD52 Tumor protein D52 0 11769800.0 0.0 5791200.0 5978600.0 False True 0.0 4927175.533920799 5359991.822780742 0.0 LGINSLQELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGINSLQELK 10 0 P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;H0YC42;E5RFR7;H0YC44;P55327-8 P55327-2 TPD52 Tumor protein D52 0 5438400.0 3819000.0 1619400.0 0.0 False True 3697767.935414913 2266034.865059435 0.0 1.0 0.6128115405395691 0.0 21.818223256226506 -7.620456453559088 0.671347473291612 0.9971904394929616 2.913847105294609e-21 0.9871775398954413 0.04661909300487683 0.12119215481798905 0.1474891312765698 0.04241547924388221 0.07733062161627934 2.396313014533668e-08 7.620456453559088 -0.9971904394929616 down LGINSLQELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGINSLQELK 10 0 P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;H0YC42;E5RFR7;H0YC44;P55327-8 P55327-2 TPD52 Tumor protein D52 0 10123600.0 0.0 5831300.0 4292300.0 False True 0.0 5573653.884469595 3278547.1426933724 0.0 LGIQLDFEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGIQLDFEK 9 0 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 0 24809300.0 9271300.0 15538000.0 0.0 False True 14065239.92282075 12765122.501051877 0.0 1.0 0.9075652154600333 0.0 23.745630826356614 -7.108384204927947 0.9809110969029095 0.9993788761071537 2.094694105167409e-18 0.9895521523627386 0.046119100243062414 0.08504136725328416 0.15545640951485992 0.0381308481912988 0.06728269468273934 7.791405275472307e-08 7.108384204927947 -0.9993788761071537 down LGIQLDFEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGIQLDFEK 9 0 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 0 9403100.0 3624700.0 1676000.0 4102400.0 False True 3014098.6514365985 1666971.0553400472 4960192.872645528 1.0 0.5530578949516218 1.6456637443772353 21.523295206435492 -6.795631108553762 1.4736268805140489 0.7520198170021379 1.6591785324471355 0.8190968274140447 0.19076218172501636 0.22705401011115867 0.9738119939716664 0.10186004744288106 0.23755296316799446 1.6009172767081197e-07 6.795631108553762 0.9071587154449976 LGIQLDFEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGIQLDFEK 9 0 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 0 20851300.0 9271300.0 11580000.0 0.0 False True 12001880.614645176 10935562.820361886 0.0 1.0 0.9111541075502679 0.0 23.516757148449063 -7.104492041691517 0.9852161486864808 1.0000095848158974 3.3644060465242896e-18 0.98950737907162 0.046291873499458944 0.08487624938164945 0.15661521707275025 0.038215060527035265 0.06747537427110563 7.861545970495055e-08 7.104492041691517 -1.0000095848158974 down LGK(ub)DPNTYFIVGTAMVYPEEAEPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGKDPNTYFIVGTAMVYPEEAEPK 24 1 Q16531;F5GY55;Q16531-2;F5H198 Q16531 DDB1 DNA damage-binding protein 1 1 45491000.0 12262000.0 10967000.0 22262000.0 True False 11872749.52187946 15346180.292149458 16430914.35431557 1.0 1.2925548765152548 1.3839182174302747 23.50115074091276 -12.891871238076453 0.17720473529266637 2.6108830062937115e-06 1.4626168767293528 0.9994816845129622 0.0037280343594423924 7.876173316399087 0.12479100497265677 2.8212381364192454 0.06962953802874661 1.282710831171448e-13 12.891871238076453 1.4626142658463466 LGK(ub)DPNTYFIVGTAMVYPEEAEPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGKDPNTYFIVGTAMVYPEEAEPK 24 1 Q16531;F5GY55;Q16531-2;F5H198 Q16531 DDB1 DNA damage-binding protein 1 1 10485500.0 3375800.0 3622800.0 3486900.0 True False 2807127.2732970137 3603283.257330504 4215994.668395985 1.0 1.283619482310965 1.5018893900896182 21.420663045498035 -6.9740430352317615 0.12914065232580965 0.6575958971684127 2.1335584631323954 0.9999992418396773 0.00017881764735527085 0.07501128568810034 0.003874169089536226 0.013863553591178055 0.029950581914022285 1.0615903565743465e-07 6.9740430352317615 1.4759625659639828 LGK(ub)SNIQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGKSNIQAR 9 1 X6R700;Q9Y3Y2-4;Q9Y3Y2;Q9Y3Y2-3;Q5T7Y7 X6R700 CHTOP Chromatin target of PRMT1 protein 1 10794300.0 2830900.0 5029500.0 2933900.0 True False 2741034.6290563154 7037805.578496016 2165423.5748866415 1.0 2.5675726617576498 0.7900022684617284 21.386289123993603 -6.673883576364884 1.9236907091910158 1.9972098209799656 0.7970619291215121 0.2963660564748275 0.6652793884018408 0.45223686758399334 3.230047842715883 0.2780591354429211 0.7391398531889803 2.1189290917260402e-07 6.673883576364884 -1.2001478918584536 LGK(ub)SNIQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGKSNIQAR 9 1 X6R700;Q9Y3Y2-4;Q9Y3Y2;Q9Y3Y2-3;Q5T7Y7 X6R700 CHTOP Chromatin target of PRMT1 protein 1 11010860.0 2830900.0 7726400.0 453560.0 True False 2354018.7801340446 7684776.349629685 548397.2989755034 1.0 3.264534851838392 0.23296215969197837 21.16669439942788 -6.706743185895263 1.8068047533538518 2.3967851506991456 0.24074052027888818 0.44964205335387475 0.9547617414446635 0.3816518651379978 2.4266186808770915 0.4208436717654936 1.0733881928572773 1.9645216264353852e-07 6.706743185895263 -2.1560446304202574 LGK(ub)VADWTGATYQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGKVADWTGATYQDK 15 1 O15371-2;O15371-3;O15371;B0QYA5;B0QYA6;B0QYA8 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 1 10479900.0 1770900.0 4971700.0 3737300.0 True False 2321667.049419997 4229941.739534817 3350600.0467130216 1.0 1.8219415831359405 1.4431871475929654 21.14672965927432 -10.053396332760826 5.0442967768671005 0.9999893793089057 1.6325643653677147 0.7880932152702554 0.1546258508273515 107136312.27409722 0.3059366490787306 13216.31285349308 0.052932541543009484 8.843082307178739e-11 10.053396332760826 0.6325749860588089 LGK(ub)VADWTGATYQDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGKVADWTGATYQDK 15 1 O15371-2;O15371-3;O15371;B0QYA5;B0QYA6;B0QYA8 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 1 14520300.0 2513500.0 6845200.0 5161600.0 True False 2433710.3183203423 9578524.057246415 3809622.1153191626 1.0 3.935769999059363 1.565355616336633 21.21472602529936 -6.592906729375296 2.2168264207621777 2.98325238352392 1.572330044741937 0.0009427094446212703 1.2711986277829006 0.661082138903558 6.128516335190933 0.47779393762169414 1.4166928465134032 2.5532495887290655e-07 6.592906729375296 -1.410922338781983 LGK(ub)VADWTGATYQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGKVADWTGATYQDK 15 1 O15371-2;O15371-3;O15371;B0QYA5;B0QYA6;B0QYA8 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 1 8057800.0 1770900.0 2642100.0 3644800.0 True False 2425649.586773049 2525363.28574368 2783973.30701228 1.0 1.0411080394770806 1.1477227882350167 21.209939720797212 -6.954670565350579 0.5049827561736154 0.9979540039501292 1.1955142831181278 0.9995186139095262 0.0013658441404934994 0.0816629044555894 0.02860817935205307 0.0015871623061911489 0.008796578166105878 1.1100165004650726e-07 6.954670565350579 0.19756027916799856 LGK(ub)VADWTGATYQDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGKVADWTGATYQDK 15 1 O15371-2;O15371-3;O15371;B0QYA5;B0QYA6;B0QYA8 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 1 9669400.0 2513500.0 4354600.0 2801300.0 True False 2090086.6169299262 4331140.9054795755 3387038.8782522203 1.0 2.072230342224513 1.6205256044495198 20.995131300733636 -10.196911963997193 6.351840947899665 0.9999932988994996 1.8463779733370131 0.823981167480221 0.18440768699107235 1.751305821637216e-05 2.2142119757321484e-06 0.17855338888001182 0.05951732505242054 6.354597330854962e-11 10.196911963997193 0.8463846744375135 LGLAK(ub)SIHHAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGLAKSIHHAR 11 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 1 10191300.0 1940200.0 3173600.0 5077500.0 True False 1878609.4130117858 4440835.030105369 3747550.428265088 1.0 2.3638948039687633 1.9948534284500452 20.841233712459953 -10.089681462620439 5.023878591740397 0.9999685001148201 2.179374116213808 0.9315880294554559 0.15066051068123482 52382796.94545783 1.1684050264462413 19088.196602992637 0.05157510013852868 8.134269130541798e-11 10.089681462620439 1.1794056160989879 LGLAK(ub)SIHHAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGLAKSIHHAR 11 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 1 8286700.0 1940200.0 4515100.0 1831400.0 True False 1613362.265433634 4490776.260122822 2214337.272563138 1.0 2.783489087564476 1.3724984896482477 20.62163898789423 -6.587388013223003 2.2374857010593487 2.2089628669884442 1.3763121209255649 0.0 0.7733313168006309 0.6772331516243442 6.3871510400064375 0.2888685087836902 0.8631687942770568 2.5859015518033116e-07 6.587388013223003 -0.8326507460628794 LGLAK(ub)SIHHAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGLAKSIHHAR 11 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 1 27199400.0 1397200.0 8256200.0 17546000.0 True False 1808702.9429294965 7796735.212216924 14352808.037163293 1.0 4.31067757295115 7.935414764083108 20.786524051935835 -6.995734625530218 0.26248157508862224 2.878548704592403e-14 12.261257828067277 0.9999833057260784 0.011572545663214745 0.07367700471550734 0.009111024044899618 0.07446606601823842 0.3311461718987289 1.0098697757811014e-07 6.995734625530218 12.261257828067249 LGLALNFSVFHYEIANSPEEAISLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGLALNFSVFHYEIANSPEEAISLAK 26 0 P31947-2;P31947 P31947-2 SFN 14-3-3 protein sigma 0 1122249400.0 337945200.0 358237200.0 426067000.0 False True 512687575.5035046 294306972.7399815 341854670.6982002 1.0 0.5740474058708093 0.6667894582045775 28.933504694913545 -9.958690056690159 5.746018970931236 1.0000003943832179 0.6204184320374597 0.9571468244288687 0.037861784320233106 1.913020959434142e-07 3.4652789991934696e-08 0.03665955299682804 0.012219838344037654 1.0997904478012701e-10 9.958690056690159 -0.37958196234575814 LGLALNFSVFHYEIANSPEEAISLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGLALNFSVFHYEIANSPEEAISLAK 26 0 P31947-2;P31947 P31947-2 SFN 14-3-3 protein sigma 0 602036200.0 337945200.0 55941000.0 208150000.0 False True 437476723.29580384 52827834.17390883 170268835.79935786 1.0 0.12075575993145768 0.3892066177066729 28.704631017005994 -10.252053783473956 5.475728353369764 1.0000597884002997 0.25498118914261136 0.9112638612426746 0.10959460376043098 7.999895927431157e-05 1.0927239933340352e-05 0.10612297329254869 0.035371506266508625 5.596882848319884e-11 10.252053783473956 -0.7450785992576884 LGLALNYSVFYYEIQNAPEQACHLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGLALNYSVFYYEIQNAPEQACHLAK 26 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 1780643200.0 426540000.0 559071200.0 795032000.0 False True 647092364.2509648 459300576.31677693 637893576.7250953 1.0 0.7097913708940696 0.985784428878994 29.269396412485534 -10.600570791814098 8.773336836011293 1.0000476565053726 0.847787899989692 0.28853302098699807 0.1126736941022392 0.00010506242020692568 4.783227369028825e-06 0.10912989200628802 0.03636527840113675 2.5085872359416166e-11 10.600570791814098 -0.1522597565156807 LGLALNYSVFYYEIQNAPEQACHLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGLALNYSVFYYEIQNAPEQACHLAK 26 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 1083131900.0 426540000.0 254146600.0 402445300.0 False True 552164438.360398 240003118.2971839 329204384.8374896 1.0 0.43465877485672794 0.5962071476660685 29.040522734577983 -10.74030824473123 10.462288424201445 1.0009297877588779 0.5154329612614754 0.9230540384784891 0.06595184702663211 0.001432366959498852 3.555366819406829e-05 0.06394804165407596 0.021285867098813784 1.818409766469209e-11 10.74030824473123 -0.48549682649740244 LGLAQK(ub)LMDQASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGLAQKLMDQASR 13 1 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 1 23936900.0 6186700.0 5372200.0 12378000.0 True False 8110823.612088028 4570688.700671584 11097243.29816013 1.0 0.5635295401886959 1.3682017793632286 22.951416989407182 -6.75940241250183 1.6147886753483631 0.7462854990948359 1.3710486799454749 0.6885054692798492 0.1835646212143181 0.2839180472992951 1.4589927428391007 0.08969939206138132 0.21568322597593853 1.740193681752182e-07 6.75940241250183 0.624763180850639 LGLAQK(ub)LMDQASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGLAQKLMDQASR 13 1 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 1 36078800.0 5650400.0 8997400.0 21431000.0 True False 5471031.144872583 12590108.740821147 15817578.183781207 1.0 2.301231414597323 2.891151186116961 22.38338133788059 -9.447487139496028 0.23313352753832423 1.3217088461902256e-20 3.317363395486076 0.999232210079462 0.02189161040219732 0.8607934912155863 0.09171238053317828 0.912205507248715 0.2804246854575117 3.568723169745019e-10 9.447487139496028 3.317363395486076 LGLAQK(ub)LMDQASR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGLAQKLMDQASR 13 1 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 1 43287900.0 7822900.0 12320000.0 23145000.0 True False 11867911.230597068 10121399.743400663 18570380.60518611 1.0 0.8528374999390235 1.5647556039439505 23.500562705136595 -6.852797911542997 1.2214754559275525 0.921236970867324 1.59479472218802 0.9442813385919705 0.07243221857603276 0.15440827368644874 0.44191304782261087 0.04636501823348901 0.10750362883511495 1.4034666219653597e-07 6.852797911542997 0.6735577513206961 LGLAQK(ub)LMDQASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGLAQKLMDQASR 13 1 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 1 19604400.0 6186700.0 4421400.0 8996300.0 True False 8474090.179281054 4226047.928385422 6871559.224614411 1.0 0.49870226053506095 0.8108905002468828 23.014627050930073 -10.500884245707914 5.962971838534261 1.0003646381914606 0.6547963803909742 0.6198091591029067 0.12745031516527414 0.0006184651855952432 5.1766815934502646e-05 0.12353047720708361 0.04113441234199941 3.1558456517921866e-11 10.500884245707914 -0.3455682578004864 LGLAQK(ub)LMDQASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGLAQKLMDQASR 13 1 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 1 24075700.0 5650400.0 11701000.0 6724300.0 True False 4698557.955162456 11637964.39053336 8130320.040349632 1.0 2.476922600847427 1.7303862414672544 22.163786613314866 -10.246832773134333 5.515804901158678 0.9999226496831306 2.1036544211573505 0.7445128000806501 0.30477219248625376 0.0002899511459783622 3.959251886521656e-05 0.29511480247328953 0.09836480215717217 5.6645736377389225e-11 10.246832773134333 1.1037317714742199 LGLAQK(ub)LMDQASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGLAQKLMDQASR 13 1 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 1 29054900.0 7822900.0 10382000.0 10850000.0 True False 10126898.262412809 9804232.573488537 8875411.33040132 1.0 0.9681377574294506 0.8764195215966045 23.271689027229044 -6.952376897600838 0.5321253138121314 1.0014248231377714 0.8389537536352555 0.9993747537779324 0.001309920023956003 0.0825454045594728 0.03212130086212254 0.0014568718305157584 0.007586722426925281 1.115894410980774e-07 6.952376897600838 -0.16247106950251589 LGLCFSWDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGLCFSWDR 9 0 A0A499FJL2;A0A494C1E0;Q15031;E9PHM2 A0A499FJL2 LARS2 Probable leucine--tRNA ligase, mitochondrial 0 18773300.0 6299800.0 3952500.0 8521000.0 False True 9557257.177071845 3247145.493976549 6836820.615113033 1.0 0.33975704889123953 0.7153538393331903 23.18816521004096 -10.725575757600165 6.981989253985059 1.0057322317116442 0.5275554441125017 0.6784135081878176 0.1533367476016402 0.013731367497031447 0.0005397051467564895 0.14900287448920796 0.04948922248523019 1.8811535323327542e-11 10.725575757600165 -0.4781767875991425 LGLCFSWDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGLCFSWDR 9 0 A0A499FJL2;A0A494C1E0;Q15031;E9PHM2 A0A499FJL2 LARS2 Probable leucine--tRNA ligase, mitochondrial 0 16956900.0 6299800.0 6105600.0 4551500.0 False True 8155215.287623279 5765817.992746252 3723173.702333789 1.0 0.7070099058570184 0.4565389840761463 22.95929153213341 -7.110395765449237 0.18480698868242124 1.1910150853744341 1.4375859189888125e-13 0.9999951670979552 0.0004882126339105409 0.07778709922541764 0.006777763009655318 0.011326705223339192 0.03029495892810772 7.755400575579433e-08 7.110395765449237 -1.1910150853742905 down LGLELGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGLELGK 7 0 B1ALA9;P60891;A0A2R8Y7H4;B1ALA7;P11908;P11908-2;D3YTJ7;A6NMS2 B1ALA9;P11908 PRPS1;PRPS2 Ribose-phosphate pyrophosphokinase 1;Ribose-phosphate pyrophosphokinase 2 0 14385600.0 4302700.0 4765900.0 5317000.0 False True 5640881.367406074 4054846.297332692 4766847.844265423 1.0 0.7188320464887368 0.8450537307536801 22.42748916546662 -10.033371081331113 4.5306351671165075 1.0000087105560795 0.7819428886219184 0.7991702635107858 0.05152978687570963 35632558.592521496 1.3721110255293605 3383.372981237546 0.01764001665131735 9.260382352606921e-11 10.033371081331113 -0.21806582193416113 LGLELGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGLELGK 7 0 B1ALA9;P60891;A0A2R8Y7H4;B1ALA7;P11908;P11908-2;D3YTJ7;A6NMS2 B1ALA9;P11908 PRPS1;PRPS2 Ribose-phosphate pyrophosphokinase 1;Ribose-phosphate pyrophosphokinase 2 0 20924300.0 4302700.0 5621600.0 11000000.0 False True 5893524.466095429 5373219.123854758 8402026.552111244 1.0 0.9117157576533516 1.4256370021787226 22.490699226989513 -6.862630384961584 1.1722811818844765 0.9517187631783448 1.4518143619740576 0.9567636394118052 0.046653995283333055 0.14412192550407596 0.3748521374945663 0.03100388223034328 0.07260485937188564 1.3720489792355754e-07 6.862630384961584 0.5000955987957127 LGLGEGAEEK(ub)SIPTLISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGLGEGAEEKSIPTLISR 18 1 P18754;P18754-2;C9JW69 P18754 RCC1 Regulator of chromosome condensation 1 24982400.0 4038100.0 9304300.0 11640000.0 True False 5293988.205016024 7916134.707877331 10435604.458764233 1.0 1.4953064497531063 1.9712179277008126 22.33592354984244 -6.971611958065518 0.2162464250304394 0.7698577643883789 2.7100468736185173 0.9999923737107159 0.0010950161635548256 0.07578304431202455 0.007128072656404658 0.01356936053964126 0.04862752592563798 1.0675495502907881e-07 6.971611958065518 1.9401891092301384 LGLGEGAEEK(ub)SIPTLISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGLGEGAEEKSIPTLISR 18 1 P18754;P18754-2;C9JW69 P18754 RCC1 Regulator of chromosome condensation 1 27909800.0 5624100.0 6687700.0 15598000.0 True False 5445566.023976702 9358133.485894775 11512415.870030299 1.0 1.7184868284933335 2.114089852063384 22.376650582920746 -9.489202875216751 0.15444237880418557 7.595153087346437e-21 2.715385313906535 0.9997621032937196 0.007112705900978339 0.9426358655636019 0.06142488045465271 0.7308048997624584 0.3157312984617708 3.2418814155038584e-10 9.489202875216751 2.715385313906535 LGLGEGAEEK(ub)SIPTLISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGLGEGAEEKSIPTLISR 18 1 P18754;P18754-2;C9JW69 P18754 RCC1 Regulator of chromosome condensation 1 84230000.0 10793000.0 13443000.0 59994000.0 True False 16373770.073992273 11043991.61936161 48136159.60369567 1.0 0.6744928974484402 2.9398336110847225 23.964883205988755 -6.87045448655631 1.1317540913517403 0.8154070045235862 3.0736165579296553 0.9651313601239591 0.1867384965068068 0.13641641579812702 0.3263054009926658 0.128021710967376 0.3033235218172874 1.3475519394704062e-07 6.87045448655631 2.2582095534060693 up LGLGEGAEEK(ub)SIPTLISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGLGEGAEEKSIPTLISR 18 1 P18754;P18754-2;C9JW69 P18754 RCC1 Regulator of chromosome condensation 1 22560000.0 4038100.0 5257900.0 13264000.0 True False 5531094.69554929 5025588.592449829 10131316.380654873 1.0 0.9086064999924469 1.8317018489680257 22.399133611365333 -6.882551756254188 1.0654362947099125 0.9411894399709559 1.9004163615377017 0.9756873322861921 0.06475404435057226 0.12539502528501198 0.25881527414735356 0.04670422950672879 0.11371469559658809 1.3105338525735725e-07 6.882551756254188 0.9592269215667457 LGLGEGAEEK(ub)SIPTLISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGLGEGAEEKSIPTLISR 18 1 P18754;P18754-2;C9JW69 P18754 RCC1 Regulator of chromosome condensation 1 32346100.0 5624100.0 10589000.0 16133000.0 True False 4676688.339874916 10531954.955248073 19506335.709436007 1.0 2.2520112930017833 4.170971912564465 22.157055858355022 -6.964896293384449 0.3598274988379519 0.8343169927494862 5.654409151590947 0.9999109920383432 0.012302967116792761 0.07799616695891541 0.014984125124221082 0.025754736474831494 0.16392035050983458 1.0841857794199956e-07 6.964896293384449 4.820092158841461 LGLGEGAEEK(ub)SIPTLISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGLGEGAEEKSIPTLISR 18 1 P18754;P18754-2;C9JW69 P18754 RCC1 Regulator of chromosome condensation 1 89211000.0 10793000.0 14952000.0 63466000.0 True False 13971751.261836587 14119908.056135675 51915839.21615215 1.0 1.0106040246152803 3.715771791468882 23.736009528081205 -6.907758004288284 0.9108480363031762 0.9101883061208779 4.049130596609761 0.9900480989409234 0.12746584506385727 0.10591987555650445 0.14694009409415282 0.10321467984480187 0.28068843088436696 1.2366363146914053e-07 6.907758004288284 3.138942290488883 up LGLGTAYIHGMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGLGTAYIHGMK 12 0 Q5QPK2;H0Y368;O60762;Q5QPJ9 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 0 19366800.0 5447400.0 3936500.0 9982900.0 False True 7141594.152696632 3349189.544356819 8949965.270738622 1.0 0.4689694587436309 1.2532167299592567 22.767814719136055 -6.724348575626294 1.7438494200619785 0.6784357399837839 1.2522893500605183 0.5328950906742507 0.2233484207835065 0.34692513965321714 2.0640834276712132 0.10161008991891839 0.2537665216632965 1.8864766079284456e-07 6.724348575626294 0.5738536100767344 LGLGTAYIHGMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGLGTAYIHGMK 12 0 Q5QPK2;H0Y368;O60762;Q5QPJ9 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 0 10921300.0 3190000.0 1474400.0 6256900.0 False True 3088735.19611772 2063135.6088944285 4618030.187023504 1.0 0.6679548351984386 1.4951201361735311 21.558584760256224 -6.79775556007671 1.4650686903148884 0.8162715023437287 1.5059146046268241 0.8255179364664629 0.14196698308678043 0.22397661239840877 0.9493355191961762 0.07624061919590416 0.1775547404855785 1.5931051439873518e-07 6.79775556007671 0.6896431022830954 LGLGTAYIHGMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGLGTAYIHGMK 12 0 Q5QPK2;H0Y368;O60762;Q5QPJ9 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 0 12680900.0 2560200.0 7909400.0 2211300.0 False True 3884010.5756911812 6497905.773575737 1774235.5857527796 1.0 1.6729886922152366 0.4568050346868699 21.889115698370787 -6.756481254975057 1.6255725002022425 1.3926141637721323 0.4530966335960007 0.6764899536232001 0.282937343020681 0.2888719501341872 1.5035967261278897 0.13738113996182896 0.33132462522188666 1.7519380497530783e-07 6.756481254975057 -0.9395175301761316 LGLGTAYIHGMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGLGTAYIHGMK 12 0 Q5QPK2;H0Y368;O60762;Q5QPJ9 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 0 14248100.0 5447400.0 3468900.0 5331800.0 False True 7461450.990449761 3315632.527881708 4072538.651867886 1.0 0.4443683315920096 0.5458105477179315 22.831024780658947 -10.122609139161785 5.568255172292685 1.0000065717048756 0.4950894396550914 0.9706155829270962 0.04141361131458585 3.378660426032989e-06 5.323659213486476e-07 0.04009907807442296 0.01336618557726278 7.540338816572969e-11 10.122609139161785 -0.5049171320497843 LGLGTAYIHGMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGLGTAYIHGMK 12 0 Q5QPK2;H0Y368;O60762;Q5QPJ9 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 0 8573300.0 3190000.0 3802800.0 1580500.0 False True 2652626.3409613934 3782313.5616032993 1910975.2425936689 1.0 1.4258749915875721 0.72040875606365 21.3389900356905 -6.743287332524562 1.674980753239628 1.2524271907515407 0.7197173863052371 0.6194900979792185 0.17892611589963758 0.3118922755197553 1.719392910410208 0.08447137064012407 0.20651624964322338 1.8059788813317757e-07 6.743287332524562 -0.5327098044463037 LGLGTAYIHGMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGLGTAYIHGMK 12 0 Q5QPK2;H0Y368;O60762;Q5QPJ9 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 0 9957600.0 2560200.0 4830800.0 2566600.0 False True 3314229.369086811 4561961.733385518 2099505.135539911 1.0 1.3764773723680153 0.6334821467466508 21.660242020463237 -6.768961013369553 1.5785236349185525 1.2162236535238713 0.6294750951135809 0.7265442840281815 0.15862327270170734 0.26810925870024865 1.3182936860551526 0.07921651594637524 0.18874137210738565 1.702311318081046e-07 6.768961013369553 -0.5867485584102904 LGLHSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGLHSLR 7 0 H0YGG7;P84077;P61204;P61204-2 H0YGG7;P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 0 15380100.0 2724000.0 4716300.0 7939800.0 False True 3571190.3792535216 4012646.4239934077 7118265.659939543 1.0 1.1236159369448577 1.993247322039286 21.76797361500503 -6.932568620156416 0.7253987017825927 0.9879540079576407 2.1840458765415844 0.997019448174568 0.024129391763655923 0.09132573528442148 0.07130601093719882 0.02232908718663709 0.07760508253111091 1.1679691717731343e-07 6.932568620156416 1.196091868583944 LGLHSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGLHSLR 7 0 H0YGG7;P84077;P61204;P61204-2 H0YGG7;P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 0 21088900.0 5640400.0 2356500.0 13092000.0 False True 5461348.589398861 3297462.7389851594 9662812.448418804 1.0 0.6037817738618505 1.769308860301555 22.380825814059218 -6.814994628097005 1.3935914197606605 0.785303839469032 1.7920822032493853 0.8724311704659709 0.1728271577248805 0.2000702110060017 0.7648260305140581 0.09749112160273354 0.2250341864750998 1.5311064002238067e-07 6.814994628097005 1.0067783637803531 LGLHSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGLHSLR 7 0 H0YGG7;P84077;P61204;P61204-2 H0YGG7;P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 0 15495400.0 2724000.0 4505400.0 8266000.0 False True 3731136.413332077 4306336.530634563 6313741.043613774 1.0 1.154162178377393 1.6921764160253019 21.83118367652792 -6.948011164100931 0.5802775273402129 0.993575571917847 1.8793862747309076 0.9990357446609219 0.009213585961787209 0.08429452282746783 0.039345878280652245 0.009650541450339752 0.04494671457910877 1.1271684804805613e-07 6.948011164100931 0.8858107028130606 LGLHSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGLHSLR 7 0 H0YGG7;P84077;P61204;P61204-2 H0YGG7;P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 0 10538400.0 5640400.0 2656500.0 2241500.0 False True 4690242.512087343 2642188.9072260344 2710187.286474978 1.0 0.5633373755017533 0.5778352141686673 22.161231089493494 -10.01177585093663 6.246476464322153 1.0000002883745944 0.5705862948494944 0.9991458281030818 0.00591871785123608 2.3771677410100837e-08 3.766348232414038e-09 0.0057307778025450515 0.0019102579723878316 9.732494098871398e-11 10.01177585093663 -0.4294139935251 LGLHSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGLHSLR 7 0 H0YGG7;P84077;P61204;P61204-2 H0YGG7;P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 0 9531900.0 2606600.0 3964000.0 2961300.0 False True 3374295.083767555 3743399.915363955 2422373.7855039085 1.0 1.1093872416114472 0.7178903223837843 21.68615471285867 -6.83212527485685 1.3182803904783222 1.0583711119233086 0.7068831680359187 0.9100695349265706 0.04946029944556368 0.17820998827520093 0.6049299643687555 0.02945051575359198 0.06777672594016311 1.4718878662785208e-07 6.83212527485685 -0.3514879438873899 LGLLALACSDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGLLALACSDGK 12 0 Q8WUA4;A0A087WZD8;Q8WUA4-2 Q8WUA4 GTF3C2 General transcription factor 3C polypeptide 2 0 6243600.0 1519500.0 2228500.0 2495600.0 False True 2081300.212943499 2130037.5013359794 1906190.678495347 1.0 1.023416750783662 0.9158653166135502 20.989053648038144 -6.849684984898085 1.2366820668667249 1.012492330235996 0.9115936320440522 0.9398353088391962 0.011327541947219865 0.1578051027831219 0.4645980453312093 0.007168149744544728 0.016583502276596867 1.4135624991079736e-07 6.849684984898085 -0.10089869819194386 LGLLGLANSLAIEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGLLGLANSLAIEGR 15 0 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ET17;A0A2R8Y7L2;E7ER27;A0A2R8Y7W2 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 11161400.0 4202300.0 4176800.0 2782300.0 False True 4068900.2867227276 5844618.021724258 2053532.16278916 1.0 1.4364122022837211 0.504689724024465 21.956207495198246 -6.7793562421154165 1.5385796820579174 1.2473155134541458 0.497482963492612 0.7650378883343351 0.18450108147838365 0.25157623850269045 1.176293643967367 0.0944570283960346 0.2229804753412266 1.6620487493920018e-07 6.7793562421154165 -0.7498325499615338 LGLLGLANSLAIEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGLLGLANSLAIEGR 15 0 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ET17;A0A2R8Y7L2;E7ER27;A0A2R8Y7W2 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 10781700.0 1185800.0 1945400.0 7650500.0 False True 1624222.3050400808 1859445.7954224886 5843609.46699337 1.0 1.144822226398746 3.5977891997051277 20.63131767501829 -6.919012446234881 0.8320344090149668 0.9439258577087597 3.9844837792192767 0.9939018171659832 0.09307977010577255 0.0987562632546586 0.10865632458435194 0.07978106632173096 0.23676631433145207 1.2050014063261927e-07 6.919012446234881 3.040557921510517 up LGLLGLANSLAIEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGLLGLANSLAIEGR 15 0 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ET17;A0A2R8Y7L2;E7ER27;A0A2R8Y7W2 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 8160000.0 4202300.0 1587300.0 2370400.0 False True 3494398.643455194 1578748.89984562 2866039.680508715 1.0 0.45179416000590694 0.8201810877750428 21.736612770632522 -10.071393202497712 5.607044120354869 1.000002261397279 0.6359876238903829 0.5655677691925571 0.15039333349134543 4.251510885648194e-06 7.039445655937063e-07 0.14561862371143097 0.04853923966599743 8.484119900801405e-11 10.071393202497712 -0.3640146375068961 LGLQNDLFSLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGLQNDLFSLAR 12 0 E9PLK3;P55786;P55786-2 E9PLK3 NPEPPS Puromycin-sensitive aminopeptidase 0 12411100.0 1668700.0 7454600.0 3287800.0 False True 2187681.859713786 6342402.737803203 2947609.9948045574 1.0 2.89914308592977 1.3473668402544567 21.060971520989927 -6.596185242520299 2.2057799859396408 2.2803734650855243 1.352260857758787 0.009636287039496705 0.8216714031726859 0.6515258335789089 5.985486835186574 0.3099202743295152 0.9143586788669118 2.5340475357640684e-07 6.596185242520299 -0.9281126073267374 LGLQNDLFSLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGLQNDLFSLAR 12 0 E9PLK3;P55786;P55786-2 E9PLK3 NPEPPS Puromycin-sensitive aminopeptidase 0 5133000.0 0.0 1135300.0 3997700.0 False True 0.0 1588631.2105112877 2950582.441570724 0.0 LGLSDMNLYDHELVFGVSLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LGLSDMNLYDHELVFGVSLK 20 0 Q13867;K7ESE8;J3KSD8 Q13867 BLMH Bleomycin hydrolase 0 279499000.0 95010000.0 93918000.0 90571000.0 False True 144137116.1614014 77157599.1153168 72669602.1513205 1.0 0.5353069436252458 0.5041699465524673 27.102866644972593 -13.999999999999998 0.3840414488796165 8.073631418797536 0.5016257615664522 0.9998139519523574 0.00309290694564081 24.554313582570295 0.20250972054400357 143.83634967214311 0.008338709522722206 1.0000000000000041e-14 13.999999999999998 -7.572005657231084 LGLSDMNLYDHELVFGVSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LGLSDMNLYDHELVFGVSLK 20 0 Q13867;K7ESE8;J3KSD8 Q13867 BLMH Bleomycin hydrolase 0 173418000.0 95010000.0 25044000.0 53364000.0 False True 122992317.92709103 23650279.384554707 43652299.56087891 1.0 0.19229070386797997 0.35491891116936003 26.873992967065043 -10.167747548150725 7.740378847585276 1.00000026255716 0.27360480786891817 0.9637690220707599 0.06639268761199113 3.008627902984274e-07 3.242390992313796e-08 0.06428446634628482 0.021428147785932765 6.795985629371645e-11 10.167747548150725 -0.7263954546882418 LGLSLVVPGGGIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGLSLVVPGGGIK 13 0 Q99747;Q99747-2 Q99747 NAPG Gamma-soluble NSF attachment protein 0 86114000.0 19906000.0 46703000.0 19505000.0 False True 26096958.769978218 39735094.44686818 17486809.705171507 1.0 1.5225948278915622 0.6700707871481265 24.637378355178534 -6.740836537853471 1.6837255299737481 1.3106395841399772 0.6694872811185503 0.6086694834916319 0.21956775995206734 0.3162965111294935 1.760970259549869 0.10315280940690494 0.25288665582943226 1.8161991251616137e-07 6.740836537853471 -0.6411523030214269 LGLSLVVPGGGIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGLSLVVPGGGIK 13 0 Q99747;Q99747-2 Q99747 NAPG Gamma-soluble NSF attachment protein 0 72712000.0 34023000.0 20604000.0 18085000.0 False True 32942958.488248665 28831284.64844057 13347995.96162955 1.0 0.8751880818089001 0.40518510097965293 24.973466788330555 -6.946263574684236 0.5984700372546826 1.0053122123097413 0.2510648737116979 0.9988744004400762 0.008592146870182218 0.08502192018035462 0.0424472341536656 0.008831831337033982 0.039478202732844324 1.1317133144078498e-07 6.946263574684236 -0.7542473385980435 down LGLSLVVPGGGIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGLSLVVPGGGIK 13 0 Q99747;Q99747-2 Q99747 NAPG Gamma-soluble NSF attachment protein 0 103373000.0 29717000.0 40520000.0 33136000.0 False True 45082861.603708684 33288889.415795002 26586655.07597527 1.0 0.7383934433535722 0.5897286492077546 25.426075756705973 -13.934757909454877 0.06584425400963764 2.5600503591700368 8.665016910963712e-08 0.9999402385302952 0.0013110496729658416 12.042901449736416 0.0667105246548984 2.9854724947372024 0.539205182861505 1.1620962253638759e-14 13.934757909454877 -2.5600502725198675 LGLSLVVPGGGIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGLSLVVPGGGIK 13 0 Q99747;Q99747-2 Q99747 NAPG Gamma-soluble NSF attachment protein 0 83661000.0 19906000.0 23433000.0 40322000.0 False True 27265786.139423054 22397652.577431485 30798774.057657223 1.0 0.8214563285614263 1.129575868459039 24.700588416701425 -6.749612803259068 1.6514395613164932 0.8949654123361016 1.1301644073569617 0.6472506313913616 0.07502348794422613 0.3007142073783705 1.6135029848169964 0.035890212122551196 0.0871616540197333 1.7798655481292236e-07 6.749612803259068 0.23519899502086006 LGLSLVVPGGGIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGLSLVVPGGGIK 13 0 Q99747;Q99747-2 Q99747 NAPG Gamma-soluble NSF attachment protein 0 61784000.0 34023000.0 12009000.0 15752000.0 False True 28291631.97446067 11944305.133400137 19045670.370980974 1.0 0.4221850879504746 0.6731909416951918 24.75387206376483 -10.357765807480133 5.883294683923885 1.0000753329691594 0.5476880148228407 0.8123684657033272 0.1024727106877057 0.00010127147652244683 1.1055112508652697e-05 0.09923519599853421 0.03307292516118422 4.3876723843799004e-11 10.357765807480133 -0.4523873181463187 LGLSLVVPGGGIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGLSLVVPGGGIK 13 0 Q99747;Q99747-2 Q99747 NAPG Gamma-soluble NSF attachment protein 0 92168000.0 29717000.0 38881000.0 23570000.0 False True 38469242.3096449 36717238.17085411 19280501.848622955 1.0 0.9544570146537164 0.501192659149125 25.197202078798423 -6.9262751339186375 0.7767699403883133 1.0079277195719674 0.41639500826984893 0.9957538387031386 0.014672941335377084 0.09461905572669504 0.08750104303732378 0.013082503083141742 0.041884139815926064 1.1850177787296445e-07 6.9262751339186375 -0.5915327113021185 LGLSTLGELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGLSTLGELK 10 0 O43399;O43399-5;O43399-7;A0A087WYR3;A0A087WZ51;O43399-2;O43399-4;O43399-3;O43399-6 O43399;O43399-2 TPD52L2 Tumor protein D54 0 21958900.0 6332500.0 7540700.0 8085700.0 False True 8301968.824017241 6415656.953418387 7249069.327511174 1.0 0.7727874061461381 0.8731747229090919 22.985022083592824 -10.1815562361547 4.599946165458252 1.000030424431422 0.822981064525662 0.8056711330808553 0.04098295045939793 1.2789537154434879e-05 2.275519470076249e-06 0.03968838681550125 0.013227190383033965 6.58330178215922e-11 10.1815562361547 -0.17704935990575998 LGLSTLGELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGLSTLGELK 10 0 O43399;O43399-5;O43399-7;A0A087WYR3;A0A087WZ51;O43399-2;O43399-4;O43399-3;O43399-6 O43399;O43399-2 TPD52L2 Tumor protein D54 0 17999000.0 5944400.0 3516200.0 8538400.0 False True 5755698.275800046 4920236.996740761 6301936.893490623 1.0 0.8548462342836839 1.09490397020762 22.45655953467961 -6.74302861094919 1.6758333124027454 0.9139365303752157 1.0951331099586457 0.6183487545754125 0.06098485897751156 0.31237248252318395 1.7236832789589407 0.028776841719863548 0.07037623216430601 1.807055074845995e-07 6.74302861094919 0.18119657958342994 LGLSTLGELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGLSTLGELK 10 0 O43399;O43399-5;O43399-7;A0A087WYR3;A0A087WZ51;O43399-2;O43399-4;O43399-3;O43399-6 O43399;O43399-2 TPD52L2 Tumor protein D54 0 3859400.0 2180000.0 0.0 1679400.0 False True 3307219.3793480136 0.0 1347465.8538928307 1.0 0.0 0.4074316515883717 21.657187317000172 -10.719423646859445 6.709228379985239 1.01043799905399 0.20371582579419262 0.8358746142827947 0.166333275241821 0.025642665603338003 0.001072361559023801 0.15902197220779207 0.05368383374430892 1.90799113766964e-11 10.719423646859445 -0.8067221732597973 LGLSTLGELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGLSTLGELK 10 0 O43399;O43399-5;O43399-7;A0A087WYR3;A0A087WZ51;O43399-2;O43399-4;O43399-3;O43399-6 O43399;O43399-2 TPD52L2 Tumor protein D54 0 21207100.0 6332500.0 5621900.0 9252700.0 False True 8673796.379377907 5373505.868862794 7067402.825338165 1.0 0.6195102621544577 0.8147992547001716 23.048232145115715 -10.531064036480789 7.299235353227047 1.0001068242449103 0.7171547584273638 0.7366290439210412 0.07972639735319777 0.00013864965710392495 8.907496159348928e-06 0.07722365807771359 0.025731584100170825 2.943987512466116e-11 10.531064036480789 -0.2829520658175465 LGLSTLGELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGLSTLGELK 10 0 O43399;O43399-5;O43399-7;A0A087WYR3;A0A087WZ51;O43399-2;O43399-4;O43399-3;O43399-6 O43399;O43399-2 TPD52L2 Tumor protein D54 0 11762500.0 5944400.0 2984900.0 2833200.0 False True 4943031.981570809 2968819.751243738 3425609.020763287 1.0 0.6006070287047383 0.6930177740170493 22.236964810113886 -10.146409852101941 5.778012384787378 1.0000041300090172 0.6468124013608826 0.9511628612010176 0.037726528794299594 2.007171513535495e-06 2.965643881775749e-07 0.036528981068630645 0.01217618481086974 7.138223601414127e-11 10.146409852101941 -0.35319172864813464 LGLSVFTHHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGLSVFTHHR 10 0 Q9BU76-4;Q9BU76 Q9BU76-4 MMTAG2 Multiple myeloma tumor-associated protein 2 0 59964000.0 11140000.0 19322000.0 29502000.0 False True 14604647.87991345 16439232.916566115 26449416.04316692 1.0 1.125616519599618 1.8110273017635854 23.799924239220353 -6.937877488042495 0.679026623413964 0.9919509673800759 1.9848614526338269 0.9978724194315477 0.016440235906170175 0.0887484603815518 0.05912100113630633 0.015756794273464877 0.059564637655462084 1.1537786862018166e-07 6.937877488042495 0.9929104852537509 LGLSVFTHHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGLSVFTHHR 10 0 Q9BU76-4;Q9BU76 Q9BU76-4 MMTAG2 Multiple myeloma tumor-associated protein 2 0 37773500.0 15320000.0 5884500.0 16569000.0 False True 14833674.985744037 8234211.537262102 12229081.840654686 1.0 0.555102598996919 0.824413495132359 23.822372728416312 -10.311966924061501 5.920626893150934 1.0000261886669606 0.6897580470646386 0.6389140968137176 0.1099457129505869 3.800993590677805e-05 4.417252431413831e-06 0.10646345039953582 0.03548482627037665 4.875656217665817e-11 10.311966924061501 -0.31026814160232197 LGLSVFTHHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGLSVFTHHR 10 0 Q9BU76-4;Q9BU76 Q9BU76-4 MMTAG2 Multiple myeloma tumor-associated protein 2 0 85646000.0 19007000.0 28741000.0 37898000.0 False True 28835008.59782919 23611943.995542027 30407443.68871651 1.0 0.8188637751028667 1.054532152662708 24.78131811677975 -6.701373006665787 1.8257676839771102 0.8876734530925148 1.0538537603634996 0.42414820889320204 0.07644089936679134 0.3926960794918619 2.5458264275647715 0.03338766282056403 0.0857255732498059 1.9889643243134662e-07 6.701373006665787 0.16618030727098487 LGLSVFTHHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGLSVFTHHR 10 0 Q9BU76-4;Q9BU76 Q9BU76-4 MMTAG2 Multiple myeloma tumor-associated protein 2 0 59952000.0 11140000.0 25421000.0 23391000.0 False True 15258759.047180377 24297816.163994614 17866527.55276676 1.0 1.5923848124782165 1.170903052962768 23.863134300743244 -10.173671834660093 3.9667629682061025 0.9998103514015599 1.3816439322825507 0.5222615673844693 0.1720692082867297 19103368.150146447 9799033.902437361 31367.639752087467 0.05890386640191024 6.703909846910342e-11 10.173671834660093 0.38183358088099073 LGLSVFTHHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGLSVFTHHR 10 0 Q9BU76-4;Q9BU76 Q9BU76-4 MMTAG2 Multiple myeloma tumor-associated protein 2 0 33838300.0 15320000.0 5727300.0 12791000.0 False True 12739258.79107478 5696445.898119953 15465538.961098127 1.0 0.44715677666513265 1.2140061847188 23.602778003850588 -6.713289701327244 1.783765051737634 0.6612684470280215 1.212363007302022 0.48060495618452514 0.23284893521311734 0.36848900450381517 2.2875500228930536 0.10380949959379997 0.26264997353746106 1.9351306812513914e-07 6.713289701327244 0.5510945602740005 LGLSVFTHHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGLSVFTHHR 10 0 Q9BU76-4;Q9BU76 Q9BU76-4 MMTAG2 Multiple myeloma tumor-associated protein 2 0 94318000.0 19007000.0 43775000.0 31536000.0 False True 24604936.1839829 41338882.768682346 25796771.58668538 1.0 1.6801052626014432 1.0484388739637671 24.5524444388722 -10.156444589979168 4.646520049464454 0.9999561642195667 1.3642720682867575 0.30720078911016335 0.2578767233190183 0.00011711774848822222 2.1262285650870275e-05 0.2497180549538994 0.08322935456375088 6.975179849352755e-11 10.156444589979168 0.36431590406719083 LGLVEFNILWNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGLVEFNILWNR 12 0 P07384 P07384 CAPN1 Calpain-1 catalytic subunit 0 73836000.0 22662000.0 23552000.0 27622000.0 False True 34379910.81412141 19348961.587384116 22162499.59284731 1.0 0.5627984811245237 0.6446351682722851 25.035062466497212 -10.8359414158892 7.359413798622175 1.0245827591688297 0.6037168246984049 0.9690063508905191 0.03340968762529957 0.012196679997950795 0.00027189223593924934 0.029278684853880983 0.010782930314564764 1.4590110601527697e-11 10.8359414158892 -0.42086593447042475 LGLVEFNILWNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGLVEFNILWNR 12 0 P07384 P07384 CAPN1 Calpain-1 catalytic subunit 0 52632000.0 22662000.0 10439000.0 19531000.0 False True 29336405.734804068 9858060.473381517 15976558.404983232 1.0 0.3360350467775993 0.5445983584154276 24.80618878858966 -10.19687238187528 5.155861323584672 1.000040469430599 0.4403167025962705 0.9056753999948804 0.08514561543070208 3.961176955455392e-05 6.170141451694694e-06 0.08244783017441039 0.02748062921365276 6.355176522899502e-11 10.19687238187528 -0.5597237668343287 LGLVGVNLTLDGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGLVGVNLTLDGVK 14 0 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 0 32592300.0 11059000.0 16038000.0 5495300.0 False True 14498456.095508328 13645192.91563436 4926699.070639788 1.0 0.9411479971209961 0.33980853121085747 23.789395943628037 -6.9258470209594245 0.7801311093126133 1.0106881227289723 0.2284731040020091 0.995657078709097 0.01965919646564669 0.09485240704462314 0.0886709578414742 0.017486197243933386 0.05570494592141471 1.1861865055303858e-07 6.9258470209594245 -0.7822150187269632 down LGLVGVNLTLDGVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGLVGVNLTLDGVK 14 0 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 0 146740730.0 80351000.0 30285730.0 36104000.0 False True 77800301.4869137 42378979.92699554 26647279.303216666 1.0 0.5447148547891404 0.342508689477236 26.213272410076378 -13.300155742307119 0.11768749203963469 2.8642684672660303 1.448228017065169e-20 0.9997279851604194 0.0045350088301262725 9.372863198234038 0.09821707922139901 4.304246395620261 0.28937561539238477 5.010075351389176e-14 13.300155742307119 -2.8642684672660303 LGLVGVNLTLDGVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGLVGVNLTLDGVK 14 0 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 0 1132924700.0 506730400.0 333357700.0 292836600.0 False True 768747063.7544814 273867413.89940166 234957317.65515897 1.0 0.35625165520875157 0.3056367025425133 29.517933754044723 -13.999999999999998 0.3605494505638029 9.451839784781166 0.29959006708967784 0.9997742831923904 0.004748624193135219 21.75615329358354 0.19410128934226703 141.52438449447357 0.014579462349313699 1.0000000000000041e-14 13.999999999999998 -9.152249717691488 LGLVGVNLTLDGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGLVGVNLTLDGVK 14 0 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 0 72752000.0 11059000.0 9016000.0 52677000.0 False True 15147811.158237677 8617643.308075026 40235777.51686948 1.0 0.5689035345141983 2.6562106628183355 23.85260600515093 -6.852856919323123 1.2212772876133304 0.7692706497944908 2.744340895917982 0.9443533544070927 0.21224366960836435 0.1543430580806838 0.44156634198376177 0.13588484200816525 0.3150641097665231 1.403275945299038e-07 6.852856919323123 1.975070246123491 up LGLVGVNLTLDGVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGLVGVNLTLDGVK 14 0 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 0 162660000.0 80351000.0 29735000.0 52574000.0 False True 66815416.65284912 29574811.65306463 63566980.32528906 1.0 0.4426345465557089 0.9513819341359815 25.993677685510654 -10.51260811999709 9.129353365255243 1.0000107611359343 0.6970082403458459 0.32108067003633234 0.20769525125760263 4.5492732248206986e-05 2.428496375472123e-06 0.20110719612515957 0.06703335410058835 3.071792530440971e-11 10.51260811999709 -0.3030025207900885 LGLVGVNLTLDGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGLVGVNLTLDGVK 14 0 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 0 931701800.0 506730400.0 222278800.0 202692600.0 False True 655972491.9494992 209908789.3812315 165804626.60170516 1.0 0.31999632904940706 0.2527615542367435 29.289060076137172 -13.999999999999998 0.32712316263177454 8.275345465337523 0.24044949856304312 0.9997088395221742 0.00575928101211726 18.583169452767407 0.18274310272650637 92.87847254836483 0.02177976879049781 1.0000000000000041e-14 13.999999999999998 -8.03489596677448 LGLVGWVQNTDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGLVGWVQNTDR 12 0 G3V2U7;P07311 G3V2U7 ACYP1 Acylphosphatase;Acylphosphatase-1 0 9394800.0 3030800.0 2814200.0 3549800.0 False True 3973408.1503089494 2394332.329665683 3182500.74808602 1.0 0.6025890719229319 0.8009498716708896 21.92194556465878 -10.127959328431743 5.192856201330889 1.0000088342610975 0.7017694717965999 0.7508667710454312 0.08098045739323308 8.282698261052136e-06 1.3910232669323506e-06 0.07841131144606683 0.02613633023753151 7.448017211326166e-11 10.127959328431743 -0.29823936246449767 LGLVGWVQNTDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGLVGWVQNTDR 12 0 G3V2U7;P07311 G3V2U7 ACYP1 Acylphosphatase;Acylphosphatase-1 0 6744400.0 2497400.0 1627500.0 2619500.0 False True 2418121.404007646 2277369.237300377 1933374.3666844699 1.0 0.9417927625660172 0.7995356905903128 21.20545524756007 -6.955945575876448 0.48923966617647846 1.0031347467018712 0.7321691422525837 0.9995890181586351 0.0017070084946231607 0.08118253213037065 0.02673450783719642 0.00204485871243405 0.01173295127009919 1.1067624705277448e-07 6.955945575876448 -0.2709656044492875 LGLVGWVQNTDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGLVGWVQNTDR 12 0 G3V2U7;P07311 G3V2U7 ACYP1 Acylphosphatase;Acylphosphatase-1 0 8382500.0 3030800.0 2593300.0 2758400.0 False True 4151368.664290332 2478719.4311036975 2106922.7310312423 1.0 0.597084872857812 0.5075248433498056 21.985155626181673 -13.99999999999996 0.21131655793820509 3.3429033598076874 0.45544240021694843 0.9994907912578951 0.004833317448636026 12.777837788285682 0.14569370219938704 12.437564336575814 0.05256582528935989 1.000000000000094e-14 13.99999999999996 -2.887460959590739 LGLYIFAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGLYIFAR 8 0 O60306 O60306 AQR Intron-binding protein aquarius 0 41841000.0 12394000.0 12401000.0 17046000.0 False True 18802604.122770324 10187944.660544753 13676850.628472785 1.0 0.5418368963162369 0.7273912985228386 24.164429150307495 -10.17011401759622 5.343170126629314 1.0000134440400503 0.6346140974194298 0.8379283353905691 0.07575226748926797 1.2132316930069806e-05 1.8842612368219151e-06 0.0733495141194142 0.02444893920189398 6.759055030984439e-11 10.17011401759622 -0.36539934662062057 LGLYIFAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGLYIFAR 8 0 O60306 O60306 AQR Intron-binding protein aquarius 0 5449400.0 1962500.0 1257500.0 2229400.0 False True 1631905.70349114 1250725.5979057935 2695557.232419057 1.0 0.7664202626598541 1.651784920325019 20.63812626570462 -6.836559433881367 1.2982005536415164 0.8756324903814897 1.6789913599072421 0.9183918232446933 0.1070263867431141 0.1728522526909615 0.5673445755166119 0.06467862265078844 0.14890403925302748 1.4569363070668654e-07 6.836559433881367 0.8033588695257524 LGLYIFAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGLYIFAR 8 0 O60306 O60306 AQR Intron-binding protein aquarius 0 34471000.0 12394000.0 11056000.0 11021000.0 False True 16044277.32226467 10440723.880994905 9015291.085009487 1.0 0.6507444162976599 0.5619007265910914 23.935555472399944 -13.999999999999998 0.1922191376826756 2.8867973096774877 0.49956718495124613 0.9994883398743715 0.004277249760806885 12.387657998907024 0.13903514298237 8.76097525637331 0.06003772738350343 1.0000000000000041e-14 13.999999999999998 -2.3872301247262415 LGMDALVAEEEAEAK(ub)GNEVRPVAGSAESAALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGMDALVAEEEAEAKGNEVRPVAGSAESAALR 32 2 B1AHH1;P17861;B1AHH2 B1AHH1 XBP1 X-box-binding protein 1;X-box-binding protein 1, cytoplasmic form;X-box-binding protein 1, luminal form 1 12503000.0 2922400.0 2056200.0 7524400.0 True False 2430105.0842713383 2045122.842476256 9097717.251105212 1.0 0.8415779448029432 3.7437546672320727 21.212587270512923 -6.893993341594288 0.9984437422020433 0.8586606473159549 4.013823808313675 0.9833341354510805 0.17199885905117554 0.115963478079377 0.20339212781668764 0.13051941809945525 0.3304363532864726 1.2764583787413381e-07 6.893993341594288 3.15516316099772 up LGMGLVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGMGLVSR 8 0 Q8N6H7;G5E9L0;A0A0D9SF70;E9PQP3;Q8N6H7-2;E9PIY6;Q8N6H7-3 Q8N6H7 ARFGAP2 ADP-ribosylation factor GTPase-activating protein 2 0 6332300.0 0.0 0.0 6332300.0 False True 0.0 0.0 5677094.339710723 0.0 LGMGLVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGMGLVSR 8 0 Q8N6H7;G5E9L0;A0A0D9SF70;E9PQP3;Q8N6H7-2;E9PIY6;Q8N6H7-3 Q8N6H7 ARFGAP2 ADP-ribosylation factor GTPase-activating protein 2 0 6014700.0 0.0 1925300.0 4089400.0 False True 0.0 1840233.8798843003 3123567.9438367058 0.0 LGMLSPEGTCK(ub)AFDTAGNGYCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGMLSPEGTCKAFDTAGNGYCR 22 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 37703800.0 10007000.0 7759800.0 19937000.0 True False 12954258.767460244 7327960.308587594 16308670.570895039 1.0 0.5656796301610612 1.2589427819568286 23.62692313221098 -6.737353190485277 1.6966802550004014 0.7407904029459715 1.2590966996240236 0.5929019317049439 0.18249689224504997 0.3226130879138103 1.8225392202830364 0.08513339034354485 0.20949606625259035 1.830824896328154e-07 6.737353190485277 0.5183062966780521 LGNADNFNYTK(ub)QGGSPVIEGVDDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGNADNFNYTKQGGSPVIEGVDDAK 25 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 49574500.0 2471100.0 8905400.0 38198000.0 True False 3748839.361608657 7316161.791792216 30648148.557221852 1.0 1.9515804989448233 8.175369921444297 21.838012576551723 -6.934037997337958 0.7128654108936683 0.9180458809192159 9.595233102833541 0.9972740791875357 0.16613413873864416 0.09059469579838793 0.06780104064666528 0.15517171649706876 0.5511780188998631 1.1640241820303946e-07 6.934037997337958 8.677187221914325 LGNADNFNYTK(ub)QGGSPVIEGVDDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGNADNFNYTKQGGSPVIEGVDDAK 25 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 40438000.0 2471100.0 5316900.0 32650000.0 True False 3198887.662663238 5021009.841069271 26708035.0172906 1.0 1.5696111806842952 8.349163157250352 21.609138898644172 -6.923513155928082 0.7982476946184281 0.8684943077573772 9.535900786919065 0.9951023082982468 0.23362450673270127 0.0961484100451559 0.09522700441368015 0.20513172434322446 0.6367057986244962 1.192578138963765e-07 6.923513155928082 8.667406479161688 up LGNDFHTNK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGNDFHTNKR 10 1 H3BNC9;P08708;H0YN88;A0A075B716;H0YN73;A0A0J9YYC4 H3BNC9 RPS17 40S ribosomal protein S17 1 10486800.0 1961400.0 3752200.0 4773200.0 True False 2571414.3942246214 3192386.385961049 4279315.051767481 1.0 1.2414904393205257 1.6641872509459354 21.29413069459402 -6.9625658649720865 0.3976222868805961 0.9761455986985375 1.9449072450182074 0.9998538452560521 0.0033185059769201726 0.07879695268889357 0.017835636236137594 0.005441137117116089 0.035446984370884005 1.0900191678657822e-07 6.9625658649720865 0.96876164631967 LGNDFHTNK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGNDFHTNKR 10 1 H3BNC9;P08708;H0YN88;A0A075B716;H0YN73;A0A0J9YYC4 H3BNC9 RPS17 40S ribosomal protein S17 1 16145200.0 3147200.0 3753900.0 9244100.0 True False 3047293.8586901804 5252851.846329887 6822792.892944421 1.0 1.723775943481776 2.238967821723982 21.539097198995158 -7.634014639500753 0.1249248112308579 2.0805932463765232e-20 3.634908288975897 0.9999894731439093 0.0016488189482926747 0.13948448630035845 0.013786993523224706 0.1542224751512791 0.22329733877113106 2.3226585012476984e-08 7.634014639500753 3.634908288975897 LGNDFHTNK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGNDFHTNKR 10 1 H3BNC9;P08708;H0YN88;A0A075B716;H0YN73;A0A0J9YYC4 H3BNC9 RPS17 40S ribosomal protein S17 1 11639200.0 1961400.0 2264700.0 7413100.0 True False 2686582.584841978 2164638.0656385883 5662278.457586907 1.0 0.8057217663256424 2.107613772803473 21.357340756116912 -6.8689243369125625 1.1398339233086372 0.8908162871709152 2.18229589394333 0.9635945069750027 0.10941315671458925 0.13788705477745306 0.3355028630975757 0.07454647790894472 0.17616169773245177 1.352308142739754e-07 6.8689243369125625 1.2914796067724148 up LGNDFHTNK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGNDFHTNKR 10 1 H3BNC9;P08708;H0YN88;A0A075B716;H0YN73;A0A0J9YYC4 H3BNC9 RPS17 40S ribosomal protein S17 1 11575400.0 3147200.0 4731400.0 3696800.0 True False 2617036.244599901 4705911.009090627 4469783.787928039 1.0 1.7981833529440008 1.7079563942422167 21.319502474429434 -10.183672377709465 4.687797470836476 0.9998877835079143 1.7530698735983126 0.9893484540961613 0.03683500166158937 25852759.22998781 6.605199815915195 31314.731493464737 0.01260960081969407 6.551302036465845e-11 10.183672377709465 0.7531820900903983 LGNDFMGITLASSQAVSNAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGNDFMGITLASSQAVSNAR 20 0 Q9HC38-2;I3L3Q4;F6TLX2;Q9HC38;Q9HC38-3 Q9HC38-2 GLOD4 Glyoxalase domain-containing protein 4 0 2983610.0 0.0 726210.0 2257400.0 False True 0.0 1016189.4401351203 1666119.2194516228 0.0 LGNGINIIVATPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGNGINIIVATPGR 14 0 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 37844000.0 10237000.0 14534000.0 13073000.0 False True 13420806.135249011 12365583.853088284 11720331.365070872 1.0 0.9213741505892672 0.8732956311981934 23.67796799539171 LGNGINIIVATPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGNGINIIVATPGR 14 0 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 43776300.0 17065000.0 9371300.0 17340000.0 False True 16523280.915908735 13113308.960683888 12798133.811150473 1.0 0.7936262191159806 0.7745516085021793 23.97799684559022 -13.999999999999993 0.3369272711333146 3.3426879189707135 0.7714414419326435 0.9997290308537815 0.001680325547398903 19.425173287281925 0.18600478575381 32.36172629748009 0.005958695081294416 1.0000000000000164e-14 13.999999999999993 -2.57124647703807 LGNGINIIVATPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGNGINIIVATPGR 14 0 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 111033000.0 27303000.0 44463000.0 39267000.0 False True 41420647.11666916 36528230.258995354 31505860.23866252 1.0 0.8818845865953426 0.7606317726017231 25.303846757236805 -6.970797553858844 0.2383763391076052 1.0444246060508697 0.5945917558949014 0.9999879470385123 0.0003392245743294346 0.07604480254055214 0.008098792821923639 0.0029320145821331656 0.011855367617470485 1.0695533347529079e-07 6.970797553858844 -0.4498328501559683 LGNGINIIVATPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGNGINIIVATPGR 14 0 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 49699000.0 10237000.0 15769000.0 23693000.0 False True 14021895.544522937 15072273.43889031 18097201.372651987 1.0 1.0749098359085736 1.2906387239292263 23.741178056914602 -6.95236570310591 0.5322373580181217 0.99665135404865 1.3787280438878935 0.9993741036853309 0.003082395734438484 0.08254944542089797 0.03213664815403862 0.0034276342080490586 0.017844929286519935 1.1159231749550891e-07 6.95236570310591 0.3820766898392435 LGNGINIIVATPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGNGINIIVATPGR 14 0 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 33258400.0 17065000.0 6725100.0 9468300.0 False True 14190303.60768218 6688870.551472167 11448077.75352713 1.0 0.47136909374166064 0.8067535459445352 23.758402121024496 -10.438370896586347 6.800845657888143 1.0000546865563766 0.6390613198431037 0.6069580315314299 0.1369201292599827 0.00011354762654344465 9.37707275917583e-06 0.1325923340325876 0.04419078169870664 3.644425723921715e-11 10.438370896586347 -0.360993366713273 LGNGINIIVATPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGNGINIIVATPGR 14 0 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 86489000.0 27303000.0 35684000.0 23502000.0 False True 35344271.72259091 33698154.03124302 19224877.150884043 1.0 0.9534261816379217 0.5439319078852636 25.074973079329254 -6.928383437046343 0.7599512383904682 1.0066151963621797 0.4632259527513605 0.9962107036195956 0.01261302630582785 0.09348625351833396 0.08185854098719925 0.011382397591545473 0.03738705691906831 1.1792789946779953e-07 6.928383437046343 -0.5433892436108192 LGNNCVFAPADVTSEK(ub)DVQTALALAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGNNCVFAPADVTSEKDVQTALALAK 26 1 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 1 15082700.0 7649400.0 3614600.0 3818700.0 True False 7406573.984069874 5057928.629889988 2818467.9114556173 1.0 0.6828971992676542 0.38053598296832025 22.820374927081556 -7.201269704304916 0.2387506542771579 1.1237145393129613 1.2846507799006782e-13 0.9999725471196387 0.0013251690480188863 0.09074076333280538 0.011882593820961542 0.012035474809362186 0.03846340208809545 6.291153701087863e-08 7.201269704304916 -1.1237145393128327 down LGNNCVFAPADVTSEK(ub)DVQTALALAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGNNCVFAPADVTSEKDVQTALALAK 26 1 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 1 8969400.0 1535800.0 1810200.0 5623400.0 True False 2103626.763434436 1730219.3784690993 4295268.737558401 1.0 0.8224935185956171 2.041839746584053 21.004447326089284 -6.869925100369221 1.1344264322331994 0.8996438752905477 2.1131691751454826 0.9646117424280048 0.10118297896849308 0.13693013565172463 0.32939155269257747 0.0692212687227246 0.16387098020990618 1.3491955485339985e-07 6.869925100369221 1.2135252998549348 up LGNNCVFAPADVTSEK(ub)DVQTALALAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGNNCVFAPADVTSEKDVQTALALAK 26 1 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 1 18964000.0 7649400.0 3272900.0 8041700.0 True False 6360815.025877771 3255268.2380802142 9723182.28938025 1.0 0.5117690460792794 1.5286063578053009 22.600780202515832 -6.776133341717091 1.550831379814303 0.7221627168999073 1.5357200948798424 0.7535015069788766 0.20615651941879767 0.2566313158601461 1.2188052069412618 0.10472867088479053 0.24793708031636214 1.6744286961649464e-07 6.776133341717091 0.8135573779799351 LGNNCVFAPADVTSEK(ub)DVQTALALAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGNNCVFAPADVTSEKDVQTALALAK 26 1 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 1 53066100.0 12460000.0 7672100.0 32934000.0 True False 16129715.623319175 7245140.890682082 26940349.931376666 1.0 0.4491797040865111 1.6702309303226808 23.9432176673397 -6.784053443614648 1.5199245103201056 0.6897551978490101 1.6811891044628788 0.7815244270050142 0.2333731201708538 0.2443239546758828 1.1150316847941775 0.12089973154872309 0.28434002106771855 1.644169381796064e-07 6.784053443614648 0.9914339066138688 LGNTISSLFGGGTTPDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGNTISSLFGGGTTPDAK 18 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 64721000.0 11610000.0 25234000.0 27877000.0 False True 15220822.431399941 21469185.561361577 24992555.455066238 1.0 1.4105141596732327 1.6419977020103464 23.85954297874589 -10.333094302915965 0.11009296496625291 3.753624910320961e-19 2.185321306749342 0.9998842939250105 0.002855565896881638 2.121435342420813 0.057000643958532056 0.8920868100894906 0.3178644696520514 4.6441442109911225e-11 10.333094302915965 2.185321306749342 LGNTISSLFGGGTTPDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGNTISSLFGGGTTPDAK 18 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 63296000.0 25770000.0 10032000.0 27494000.0 False True 24951945.4557848 14037829.91618887 20292496.59768 1.0 0.562594605741829 0.8132631034176709 24.572648968350972 -10.188092346417976 5.510172307189799 1.0000104834093986 0.6879288545797184 0.6739009063940702 0.10233498564941912 1.317973868431263e-05 1.942012993342924e-06 0.09908875008425136 0.03302847459619839 6.484965255131891e-11 10.188092346417976 -0.31208162882968016 LGNTISSLFGGGTTPDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGNTISSLFGGGTTPDAK 18 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 69540500.0 8829500.0 50425000.0 10286000.0 False True 13394997.022914367 41426264.777676806 8252967.591486037 1.0 3.092666964151638 0.616123137419737 23.67519092474777 -6.682762471391864 1.8923077456544832 2.3208045211184674 0.6254111402553625 0.33663997429656034 0.8863998417027061 0.4324573648254414 2.9963739327999273 0.3755609143545234 0.9869397527935532 2.0760486599503046e-07 6.682762471391864 -1.6953933808631048 LGNTISSLFGGGTTPDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGNTISSLFGGGTTPDAK 18 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 73817000.0 11610000.0 22839000.0 39368000.0 False True 15902530.748452816 21829897.461526766 30070089.20941049 1.0 1.3727310329930118 1.8908996112040883 23.92275304026878 -6.966489741424127 0.33149009930732826 0.9379574101398872 2.3426740617822293 0.9999406425437902 0.0028145588728307174 0.07745899430209524 0.0130968279637824 0.0075212836399692895 0.04514194765715376 1.0802151366057189e-07 6.966489741424127 1.404716651642342 LGNTISSLFGGGTTPDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGNTISSLFGGGTTPDAK 18 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 44052300.0 25770000.0 8435600.0 9846700.0 False True 21428896.80456896 8390155.748464508 11905599.444003215 1.0 0.3915346564493045 0.5555862045807586 24.353054243785248 -10.623252517723584 9.96637403953033 1.000092585334186 0.4735604305153568 0.932112004814197 0.06697376407261627 0.0001378036860011275 5.209201209910902e-06 0.06485818030660395 0.02161568940717226 2.380934687703815e-11 10.623252517723584 -0.5265321548188292 LGPGK(ub)GEVRPELGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGPGKGEVRPELGSR 15 2 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 42092000.0 16539000.0 10310000.0 15243000.0 True False 25090872.162860915 8470099.947602332 12230214.368755765 1.0 0.3375769440226805 0.48743679730905176 24.58065928414815 -10.15789480899891 7.936119515375191 1.0000001218864296 0.4125068706686061 0.9534699724238478 0.061180028913326384 1.3199870515689864e-07 1.4014511253624079e-08 0.05923732063301965 0.01974576942515011 6.951926806732464e-11 10.15789480899891 -0.5874932512178235 LGPGK(ub)PGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGPGKPGLK 9 1 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;B4DP61 A0A1W2PRV5 SMN1;SMN2 Survival motor neuron protein 1 5220900.0 2134000.0 1908600.0 1178300.0 True False 2797694.665685397 1623844.319664529 1056380.8190517093 1.0 0.5804222810950348 0.37758974630382347 21.415807087817385 -12.165039685231042 0.1159276714485453 2.3641073762039566 1.5413166529236992e-10 0.9997774026604347 0.0038669227989878772 5.967898547970601 0.08457397959323018 2.256165897388716 0.28844953417226954 6.838491552331973e-13 12.165039685231042 -2.364107376049825 LGPGK(ub)PGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGPGKPGLK 9 1 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;B4DP61 A0A1W2PRV5 SMN1;SMN2 Survival motor neuron protein 1 7560300.0 2969700.0 2946200.0 1644400.0 True False 2875428.4990315936 4122633.024230031 1213682.3090574322 1.0 1.4337456228240346 0.4220874591269386 21.45534553315988 -6.790181529615326 1.4955236236835463 1.2423563276416105 0.4112590330261573 0.8019640813367965 0.1844145257716141 0.23506500190046814 1.0386093887827224 0.09705806539357323 0.227214896518802 1.621132342851728e-07 6.790181529615326 -0.8310972946154532 down LGPGK(ub)PGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGPGKPGLK 9 1 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;B4DP61 A0A1W2PRV5 SMN1;SMN2 Survival motor neuron protein 1 13497900.0 5743100.0 4738800.0 3016000.0 True False 8712702.576850265 3893124.1155866063 2419886.278040242 1.0 0.44683312453826607 0.27774232583927555 23.054688864433746 -13.999999999999998 0.1660208885608509 3.7617791952535105 0.1220862053427667 0.9995218402469426 0.006744708994539389 12.055292755897355 0.12894044149244538 10.719666960667203 0.14301702239233238 1.0000000000000041e-14 13.999999999999998 -3.6396929899107437 LGPGK(ub)PGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGPGKPGLK 9 1 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;B4DP61 A0A1W2PRV5 SMN1;SMN2 Survival motor neuron protein 1 4708100.0 2134000.0 1551400.0 1022700.0 True False 2922997.469181593 1482854.018206253 781159.3231676529 1.0 0.5073059535085522 0.2672459799927124 21.479017149340276 -9.915521786722499 0.17766988635574016 1.6410185078459483 2.677316248963995e-23 0.9995841224270068 0.006220181610236678 1.4204909704002153 0.07958553368076639 0.6042665079705499 0.16470863746598194 1.21472568127844e-10 9.915521786722499 -1.6410185078459483 LGPGK(ub)PGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGPGKPGLK 9 1 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;B4DP61 A0A1W2PRV5 SMN1;SMN2 Survival motor neuron protein 1 8253820.0 2969700.0 4302900.0 981220.0 True False 2469437.1300166277 4279719.423641221 1186388.5653513172 1.0 1.733074866179081 0.4804287385698006 21.235750808594155 -6.74805811251455 1.6568144778417488 1.4320476445834955 0.4782672337123454 0.6406954307894457 0.30801848087989864 0.30342690463805294 1.638114693043805 0.14689318479827765 0.3573774080888197 1.7862485427114676e-07 6.74805811251455 -0.9537804108711501 LGPK(ub)SSVLIAQQTDTSDPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGPKSSVLIAQQTDTSDPEK 20 1 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 1 12424700.0 5098100.0 4851700.0 2474900.0 True False 6683658.470070631 4127845.2717784774 2218821.0889171506 1.0 0.6176026633112591 0.3319770300731274 22.67220658397341 -7.884713075400461 0.2186194323063059 1.207896460262679 4.034735192896177e-15 0.9998126999196418 0.0037453974560062147 0.11622568815696913 0.03463749993468313 0.0621209524851575 0.09372211212690258 1.3040280239073418e-08 7.884713075400461 -1.207896460262675 down LGPK(ub)SSVLIAQQTDTSDPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGPKSSVLIAQQTDTSDPEK 20 1 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 1 22368000.0 8472800.0 7548100.0 6347100.0 True False 8203835.601776232 10562095.692821488 4684604.101081497 1.0 1.2874582336260691 0.5710260820033037 22.96786715099097 -6.797796834252745 1.464807014384612 1.1590482242875069 0.5616558723468495 0.8256750489072584 0.1229094254291735 0.22391219585154024 0.9487052476300906 0.06601658797378256 0.15374661529511305 1.592953746766231e-07 6.797796834252745 -0.5973923519406573 LGPK(ub)SSVLIAQQTDTSDPEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGPKSSVLIAQQTDTSDPEK 20 1 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 1 28856300.0 6829000.0 8377300.0 13650000.0 True False 10360092.266774124 6882305.362856358 10952071.516992457 1.0 0.6643092730871342 1.0571403453728758 23.304533515906343 -6.6804142133212965 1.9002520299745198 0.7876844742791569 1.0556554154160371 0.32606895476126185 0.14226072692337158 0.43761807057581875 3.0555148040805657 0.06006153462254966 0.1583337624275744 2.087304390785098e-07 6.6804142133212965 0.26797094113688025 LGPK(ub)SSVLIAQQTDTSDPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGPKSSVLIAQQTDTSDPEK 20 1 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 1 15075600.0 5098100.0 6142200.0 3835300.0 True False 6983005.340972204 5870817.294460788 2929481.1304829316 1.0 0.8407293146425444 0.41951580837185454 22.7354166454963 -6.954245447927696 0.5101125012009361 1.0077449179380031 0.23401741803866555 0.9994937046247373 0.005510319218518858 0.08182447292490588 0.029243982464351406 0.006345576542958714 0.034764011633809204 1.1111035932259675e-07 6.954245447927696 -0.7737274998993375 down LGPK(ub)SSVLIAQQTDTSDPEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGPKSSVLIAQQTDTSDPEK 20 1 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 1 18234500.0 8472800.0 8079200.0 1682500.0 True False 7045508.608682652 8035675.746004366 2034302.9709989517 1.0 1.1405387733259549 0.28873756090396996 22.748272426425245 -6.864531604392104 1.1625489140829095 1.0773870786475388 0.24375660531311696 0.9589187690703893 0.07557283154780457 0.14221054536582142 0.36266834969034784 0.05059775932433284 0.11878674077751335 1.366055661740871e-07 6.864531604392104 -0.8336304733344219 down LGPK(ub)SSVLIAQQTDTSDPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGPKSSVLIAQQTDTSDPEK 20 1 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 1 29310300.0 6829000.0 12837000.0 9644300.0 True False 8840275.119714811 12122609.66537009 7889136.358874608 1.0 1.3712932574163108 0.8924084660307622 23.075659837998792 -6.6996649495534655 1.8315883166685814 1.2306204153968026 0.8938171088510217 0.41627874250501984 0.1567352106883859 0.3961802910448213 2.5835625995932707 0.06826778171395038 0.17567041631155625 1.996802218184119e-07 6.6996649495534655 -0.33680330654578083 LGPLFSLLNENHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGPLFSLLNENHR 13 0 Q16401;Q16401-2;F2Z3J2 Q16401;F2Z3J2 PSMD5 26S proteasome non-ATPase regulatory subunit 5 0 5224900.0 1272200.0 2118800.0 1833900.0 False True 1667866.5200023267 1802683.299017714 1644145.620010973 1.0 1.0808318755719128 0.9857776988105016 20.66957240328885 -6.681451207702469 1.897033571024616 1.0510771461797281 0.9861378488391722 0.33067544337527965 0.034247725146969395 0.4352889605866268 3.0299761484472985 0.014480562091601945 0.03811643574983123 2.0823263381465347e-07 6.681451207702469 -0.06493929734055592 LGPLFSLLNENHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGPLFSLLNENHR 13 0 Q16401;Q16401-2;F2Z3J2 Q16401;F2Z3J2 PSMD5 26S proteasome non-ATPase regulatory subunit 5 0 6090400.0 2013500.0 1630800.0 2446100.0 False True 1949582.5446341767 2281986.944509655 1805393.0285729624 1.0 1.1705002954557389 0.9260408252740742 20.894733808549745 -6.719178899520597 1.76215646396263 1.1038235824567433 0.9264376393828216 0.5086044636200227 0.07175495643383503 0.35695959349426276 2.1657660260801586 0.032336839381184285 0.08125954033455687 1.9090666921151516e-07 6.719178899520597 -0.17738594307392164 LGPLFSLLNENHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGPLFSLLNENHR 13 0 Q16401;Q16401-2;F2Z3J2 Q16401;F2Z3J2 PSMD5 26S proteasome non-ATPase regulatory subunit 5 0 7138200.0 1272200.0 2787400.0 3078600.0 False True 1742566.7199122894 2664243.451300837 2351498.0857572462 1.0 1.5289190484683075 1.3494450794260588 20.73278246481174 -10.226023268324267 4.4814398222770455 0.9998521507118694 1.4391820639513275 0.8886920224184212 0.07326994106813481 51638593.82956492 21.209018612308082 79564.80707156118 0.025082249690203957 5.942603189012758e-11 10.226023268324267 0.43932991323945814 LGPLLGK(ub)GGFGTVFAGHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGPLLGKGGFGTVFAGHR 18 1 Q9P1W9 Q9P1W9 PIM2 Serine/threonine-protein kinase pim-2 1 48924800.0 9519800.0 10266000.0 29139000.0 True False 9217599.159875061 14365267.336482778 21506621.74873781 1.0 1.5584608407594815 2.3332129522791396 23.135959600761577 -6.966522691985636 0.3308785978865325 0.906572273506594 3.010497444080864 0.9999411798645268 0.004192598396454925 0.07744797108583941 0.013058249454245312 0.011269743294163295 0.06752795766426006 1.0801331822025512e-07 6.966522691985636 2.10392517057427 LGPLLGK(ub)GGFGTVFAGHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGPLLGKGGFGTVFAGHR 18 1 Q9P1W9 Q9P1W9 PIM2 Serine/threonine-protein kinase pim-2 1 22713100.0 5127100.0 4764000.0 12822000.0 True False 7022727.424667735 4553510.727558718 9793707.677379142 1.0 0.6483963355268851 1.394573231331488 22.74360000980473 -6.778567118646642 1.541411187819752 0.8005423421175266 1.4002247920752402 0.7622967301912309 0.14860165656851718 0.25280963976867904 1.1863201084278034 0.07593861828749668 0.17940222536172912 1.6650714771046575e-07 6.778567118646642 0.5996824499577136 LGPLLGK(ub)GGFGTVFAGHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGPLLGKGGFGTVFAGHR 18 1 Q9P1W9 Q9P1W9 PIM2 Serine/threonine-protein kinase pim-2 1 43059800.0 9519800.0 11803000.0 21737000.0 True False 7916135.4986471 11739414.89628794 26282106.199467596 1.0 1.482972960517699 3.320067753256537 22.916364876195853 -6.946031548795441 0.6008350207678476 0.9793451959375226 3.9178720259812643 0.9988519076757213 0.03386636598880971 0.08511950683985399 0.042866753063560886 0.03472990878580291 0.15442689160277187 1.1323181043736427e-07 6.946031548795441 2.9385268300437417 up LGPLLLDPSLAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGPLLLDPSLAVR 13 0 Q7Z4Q2 Q7Z4Q2 HEATR3 HEAT repeat-containing protein 3 0 2242490.0 400640.0 943280.0 898570.0 False True 525242.9198032788 802546.3008766406 805594.5960920783 1.0 1.527952630331926 1.533756221585625 19.002625284150852 -11.38132639312346 0.717296403281917 2.1730839826090016e-06 1.5326942307691704 0.9999861316441928 0.0009319504108261572 4.5947899578186915 0.37001936942176933 7.266197561636539 0.0008913315737317196 4.1559815116004975e-12 11.38132639312346 1.532692057685188 LGPLLLDPSLAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGPLLLDPSLAVR 13 0 Q7Z4Q2 Q7Z4Q2 HEATR3 HEAT repeat-containing protein 3 0 2216680.0 400640.0 798940.0 1017100.0 False True 548767.4348889 763640.1890587253 776881.9278320322 1.0 1.3915552208620525 1.415685185454408 19.065835345673744 -11.865733964117487 0.4400239137134438 1.980457819447928e-11 1.4160272755255314 0.9998040823714514 0.002666758461112824 5.338354960243224 0.22018653424033344 4.983885376530535 0.0055715989841020495 1.3622789184733518e-12 11.865733964117487 1.4160272755057268 LGPNDQYK(ub)FYSVNVDYSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGPNDQYKFYSVNVDYSK 18 1 O00483 O00483 NDUFA4 Cytochrome c oxidase subunit NDUFA4 1 11379600.0 2750200.0 2731300.0 5898100.0 True False 2662896.4063833673 3821922.3335413397 4353210.670792773 1.0 1.4352500999962339 1.6347653105683968 21.34456487436387 -11.253669029470238 0.14208314047446088 1.1722035752795263e-15 1.9217296323597672 0.9996775949890052 0.004758809376143664 3.746966820163194 0.0874037402615608 1.397096385267389 0.20511166983366413 5.576105352396842e-12 11.253669029470238 1.9217296323597661 LGPNDQYK(ub)FYSVNVDYSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGPNDQYKFYSVNVDYSK 18 1 O00483 O00483 NDUFA4 Cytochrome c oxidase subunit NDUFA4 1 37198200.0 6528300.0 26121000.0 4548900.0 True False 9903908.382659456 21459503.465695463 3649807.9211462997 1.0 2.16677120148531 0.3685219794174057 23.23956653810755 -6.7315355580020215 1.7173627977956536 1.7009278068849008 0.369229042193672 0.5665344516083026 0.4904248537334811 0.3333440317627006 1.9267067032824587 0.22622567215680736 0.5604479278967454 1.8555148823293603e-07 6.7315355580020215 -1.3316987646912288 LGPNYLHIPVNCPYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGPNYLHIPVNCPYR 15 0 P04040 P04040 CAT Catalase 0 14897600.0 3354300.0 4868300.0 6675000.0 False True 4594475.356549118 4653202.408684738 5098502.47594024 1.0 1.0127821018893721 1.1097028670907256 22.13146869879965 -6.931108108250082 0.737645691519773 0.9985850382326247 1.130173151629489 0.9967514530617844 0.0027916834533979386 0.09206665528478575 0.07489291810752988 0.0025603223157829843 0.008716845526008817 1.1719036090932154e-07 6.931108108250082 0.13158811339686438 LGPVPSGLSQK(ub)GTQIPDHFRPPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGPVPSGLSQKGTQIPDHFRPPLR 24 2 J3KNZ9;Q9HAH7;Q9HAH7-1 J3KNZ9 FBRS Probable fibrosin-1 1 25876400.0 8896100.0 9086800.0 7893500.0 True False 8613698.17497894 12715206.62703599 5825955.550075907 1.0 1.476161152705711 0.6763593791803776 23.038201341581683 -6.745446208998732 1.6667709833063393 1.2815168909711445 0.6753141346890368 0.629094922049956 0.2000573620083006 0.3080668741149875 1.6823962234103804 0.0948772233062497 0.23144173508238808 1.7970236427871545e-07 6.745446208998732 -0.6062027562821077 LGPVPSGLSQK(ub)GTQIPDHFRPPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGPVPSGLSQKGTQIPDHFRPPLR 24 2 J3KNZ9;Q9HAH7;Q9HAH7-1 J3KNZ9 FBRS Probable fibrosin-1 1 23034400.0 8896100.0 9789700.0 4348600.0 True False 7397501.3140522335 9736960.942996698 5257872.154345349 1.0 1.3162499781514665 0.7107632606103818 22.81860661701596 -6.764780132461809 1.5945831324412207 1.182598001516351 0.7080193719182115 0.7101626638272607 0.1331221071274758 0.27494432043138795 1.3788468065025277 0.06583954339766818 0.15747844376204248 1.7187783220308496e-07 6.764780132461809 -0.47457862959813957 LGPVPSGLSQK(ub)GTQIPDHFRPPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGPVPSGLSQKGTQIPDHFRPPLR 24 2 J3KNZ9;Q9HAH7;Q9HAH7-1 J3KNZ9 FBRS Probable fibrosin-1 1 40199000.0 11736000.0 18041000.0 10422000.0 True False 15192483.35114555 17037002.490686458 8525302.93875046 1.0 1.1214099826149768 0.5611526925324971 23.856854375101722 -6.849984528366017 1.2353226622346984 1.0647834532689278 0.538782187633235 0.9402596203931828 0.05881951299435828 0.1574771360821931 0.4624768785031534 0.03726047642663145 0.08621389822747784 1.4125878668213308e-07 6.849984528366017 -0.5260012656356927 LGQGVLVQVSPSLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGQGVLVQVSPSLVK 15 0 Q13868;Q13868-3 Q13868 EXOSC2 Exosome complex component RRP4 0 25627500.0 6197500.0 8215000.0 11215000.0 False True 8124982.516675364 6989354.021819198 10054579.381876364 1.0 0.8602300383384885 1.2374893559759395 22.953933277967042 -6.806426073080421 1.4297919937558905 0.9234987031834642 1.2435452748534346 0.850207782325077 0.060271481414484455 0.2117218639707534 0.8537451950789924 0.033154384292185944 0.07681435204562082 1.5616148381448546e-07 6.806426073080421 0.3200465716699704 LGQGVLVQVSPSLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGQGVLVQVSPSLVK 15 0 Q13868;Q13868-3 Q13868 EXOSC2 Exosome complex component RRP4 0 26888200.0 11374000.0 6338600.0 9175600.0 False True 11012938.595812818 8869636.035362324 6772235.097900373 1.0 0.8053832279365118 0.6149344281711708 23.39269614055622 -6.971391621627524 0.22246923666096993 1.085133642757908 0.32979085956918897 0.9999912922578197 0.0004638597496488409 0.07585382587342902 0.007394045206880379 0.005176957516880489 0.01920331223710399 1.0680913019221405e-07 6.971391621627524 -0.755342783188719 LGQGVLVQVSPSLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGQGVLVQVSPSLVK 15 0 Q13868;Q13868-3 Q13868 EXOSC2 Exosome complex component RRP4 0 53890000.0 11778000.0 25232000.0 16880000.0 False True 17868087.08713803 20729152.461484194 13543660.601233188 1.0 1.1601215261820412 0.7579804449790436 24.09088185552321 -6.798648150904786 1.461340880654698 1.0884974809785053 0.7526070041985641 0.828213596990674 0.06851390650965437 0.22268721105540384 0.938978798527824 0.03688558246572518 0.08585711700656365 1.5898342510464657e-07 6.798648150904786 -0.3358904767799412 LGQGVLVQVSPSLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGQGVLVQVSPSLVK 15 0 Q13868;Q13868-3 Q13868 EXOSC2 Exosome complex component RRP4 0 28141700.0 6197500.0 9802200.0 12142000.0 False True 8488883.231140066 9369106.392459292 9274309.672339525 1.0 1.1036912792121198 1.0925241188756434 23.017143339489934 -10.097789420970194 4.125460478066235 0.9999814561822719 1.0981076990714154 0.9903763117879905 0.004558974205636467 634878.5532089821 777806.4226005235 82.1507981617939 0.0015606581888305776 7.983817096690122e-11 10.097789420970194 0.09812624288914351 LGQGVLVQVSPSLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGQGVLVQVSPSLVK 15 0 Q13868;Q13868-3 Q13868 EXOSC2 Exosome complex component RRP4 0 21366600.0 11374000.0 4832700.0 5159900.0 False True 9457984.953634745 4806665.285884161 6238811.233317985 1.0 0.508212405649571 0.6596342946094859 23.173101415990498 -10.869088429646686 11.015626963665076 1.0150348922396897 0.5839233501295346 0.9096427961486498 0.06181772730669412 0.020648774520327092 0.00024539308072215243 0.05414622976462344 0.019951585696601475 1.3517972865506234e-11 10.869088429646686 -0.4311115421101551 LGQGVLVQVSPSLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGQGVLVQVSPSLVK 15 0 Q13868;Q13868-3 Q13868 EXOSC2 Exosome complex component RRP4 0 38033000.0 11778000.0 15785000.0 10470000.0 False True 15246853.17908933 14906550.873869821 8564567.431272058 1.0 0.9776804891329166 0.5617268908326699 23.86200817761566 -6.917991960040675 0.8394833766040096 1.0098587254932037 0.4976534317780885 0.9936047200503837 0.016117991517555316 0.09936786931021074 0.11184238259458061 0.013741600813032972 0.0404047165202041 1.2078361951974508e-07 6.917991960040675 -0.5122052937151151 LGQMVLEYDHPLKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGQMVLEYDHPLKK 14 1 P55160;P55160-2;F8W050 P55160 NCKAP1L Nck-associated protein 1-like 0 6402500.0 2337000.0 1364200.0 2701300.0 False True 3063829.631540196 1160666.6776099496 2421795.3886992983 1.0 0.37882872652631117 0.790447146201747 21.546904645775786 -10.071156532610138 5.828707618638474 1.0000016012894153 0.5846379363640777 0.5758572500668966 0.1680425161560772 3.496753956863802e-06 5.569761306972709e-07 0.16270709450571694 0.05423548887725217 8.488744603626383e-11 10.071156532610138 -0.4153636649253376 LGQMVLEYDHPLKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGQMVLEYDHPLKK 14 1 P55160;P55160-2;F8W050 P55160 NCKAP1L Nck-associated protein 1-like 0 5818400.0 2337000.0 1295000.0 2186400.0 False True 3201052.055050323 1237782.618007669 1670017.350321459 1.0 0.38667994044483295 0.5217089011991106 21.610114707298678 -9.952641426064096 7.0746760890457185 1.0000000212478692 0.45419442082280287 0.9561117917044821 0.05512534239104933 1.8539871493079535e-08 2.6981231632236037e-09 0.053374885644664145 0.017791627752875818 1.1152149274379272e-10 9.952641426064096 -0.5458056004250664 LGQSDPAPLQHQMDIYQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGQSDPAPLQHQMDIYQK 18 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 33658000.0 0.0 18290000.0 15368000.0 False True 0.0 15561203.293861607 13777866.780265383 0.0 LGQSDPAPLQHQMDIYQK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LGQSDPAPLQHQMDIYQK 18 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 44027280.0 15941200.0 5932980.0 22153100.0 False True 15435155.331771698 8302049.854081959 16350538.531245548 1.0 0.5378662977879487 1.0593050850346564 23.879716665807212 -6.672809340424748 1.9271775688700858 0.7057419735899678 1.0572365014362648 0.2916525863554198 0.196177325187278 0.45469932241712796 3.2583257536209635 0.08186854534946243 0.21795290582052435 2.124176791966332e-07 6.672809340424748 0.351494527846297 LGQSDPAPLQHQMDIYQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGQSDPAPLQHQMDIYQK 18 0 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 0 47943000.0 0.0 28628000.0 19315000.0 False True 0.0 27363120.299863752 14753194.8049117 0.0 LGQSDPAPLQHQMDIYQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 2 LGQSDPAPLQHQMDIYQKR 19 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 27378500.0 7888300.0 7367400.0 12122800.0 True False 10341637.690405855 6268212.637900278 10868448.94610886 1.0 0.6061141209496659 1.0509407959816401 23.30196133156079 -6.67304938078335 1.9268639430295333 0.749240710611286 1.0491563717549242 0.2924927290223712 0.16719846792175094 0.45415430725782313 3.2537411147380224 0.06978967380573813 0.18570187171548955 2.1230030554923947e-07 6.67304938078335 0.2999156611436381 LGQSDPAPLQHQMDIYQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 2 LGQSDPAPLQHQMDIYQKR 19 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 32978100.0 10660800.0 9053500.0 13263800.0 True False 10322378.739426881 12668609.763378799 9789612.874529291 1.0 1.2272955762599915 0.9483872973132964 23.299272134984765 -6.689983370828484 1.8662026356449795 1.1424984665571278 0.9493437047474552 0.37049417206181245 0.09612977778439548 0.41669108582084924 2.813571054685852 0.04120573624834363 0.10731562402338807 2.0418161244805003e-07 6.689983370828484 -0.19315476180967261 LGQSDPAPLQHQMDIYQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGQSDPAPLQHQMDIYQKR 19 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 95140000.0 13033000.0 23559000.0 58548000.0 True False 19772013.83992783 19354712.38269283 46975962.137499966 1.0 0.9788943371872268 2.375881512010485 24.236956485653582 -6.903470675968178 0.9390616918241286 0.94731886937981 2.5333106616910612 0.9882154121526774 0.07095581396460911 0.10889561304204261 0.16336044442736022 0.056278860067261786 0.14915059179018567 1.2489047691405277e-07 6.903470675968178 1.5859917923112512 up LGQSDPAPLQHQMDIYQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LGQSDPAPLQHQMDIYQKR 19 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 28905800.0 7888300.0 8130600.0 12886900.0 True False 10804817.683292003 7771363.207701286 9843279.634036595 1.0 0.7192498231338517 0.9110083966763938 23.36517139308368 -10.079986694829437 5.013614360992957 1.000004511039317 0.8151291104367554 0.553426053348995 0.07828510983334724 3.94749707062403e-06 7.243294907701528e-07 0.07580108160113011 0.025266410552978038 8.31789253646954e-11 10.079986694829437 -0.18487540060256158 LGQSDPAPLQHQMDIYQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LGQSDPAPLQHQMDIYQKR 19 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 33160500.0 10660800.0 10559100.0 11940600.0 True False 8864927.553517614 10502216.032482754 14437324.252903491 1.0 1.1846928211291996 1.6285890849919855 23.07967741041904 -6.95630023842117 0.48477107164141153 0.989809198683197 1.8421298897226008 0.9996074211843692 0.0052266814580682105 0.08105020007899236 0.026223277560688017 0.006320633590183716 0.03661300909290774 1.105859012212405e-07 6.95630023842117 0.8523206910394039 LGQSDPAPLQHQMDIYQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGQSDPAPLQHQMDIYQKR 19 1 P29401;P29401-2;A0A0B4J1R6;E9PFF2 P29401 TKT Transketolase 1 93162000.0 13033000.0 17620000.0 62509000.0 True False 16871475.41883777 16639431.510775164 51133003.3965029 1.0 0.986246377254978 3.030736917022122 24.00808280774603 -6.905385219590358 0.9265997647797847 0.9270947202303964 3.2704375695776102 0.9890601769520295 0.10046809532860483 0.10754900120569441 0.15591004824841817 0.08042209053442563 0.21550331828440758 1.2434112156367634e-07 6.905385219590358 2.3433428493472137 up LGSALGGPYLGVHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGSALGGPYLGVHLR 15 0 A0A0C4DGX7;H7C2T5;Q9Y2G5-2;Q9Y2G5-1;Q9Y2G5 A0A0C4DGX7 POFUT2 GDP-fucose protein O-fucosyltransferase 2 0 6442600.0 2325500.0 2152500.0 1964600.0 False True 2251678.275414341 3012004.475139209 1450012.3232633355 1.0 1.3376708866567348 0.6439695844187654 21.1025692761286 -6.774369080344804 1.5579218319895307 1.1926010971398213 0.6394262103813145 0.7468968661655566 0.1424939219518509 0.25943726218826013 1.2432862426312388 0.07207185214135983 0.17086917913028973 1.6812446666607593e-07 6.774369080344804 -0.5531748867585068 LGSALGGPYLGVHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGSALGGPYLGVHLR 15 0 A0A0C4DGX7;H7C2T5;Q9Y2G5-2;Q9Y2G5-1;Q9Y2G5 A0A0C4DGX7 POFUT2 GDP-fucose protein O-fucosyltransferase 2 0 6090800.0 1100400.0 1509500.0 3480900.0 False True 1507247.6171918595 1442805.2987510278 2658783.1113858237 1.0 0.9572450354501846 1.7639988818422419 20.5234850179447 -6.894393114786502 0.9960630981672114 0.9611057503153636 1.839658047385356 0.983563301915764 0.047518308327303645 0.1156500882907703 0.2016203438098371 0.036124382298544234 0.09160329258975729 1.2752839243829441e-07 6.894393114786502 0.8785522970699925 LGSALGGPYLGVHLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGSALGGPYLGVHLR 15 0 A0A0C4DGX7;H7C2T5;Q9Y2G5-2;Q9Y2G5-1;Q9Y2G5 A0A0C4DGX7 POFUT2 GDP-fucose protein O-fucosyltransferase 2 0 5373700.0 2325500.0 1594700.0 1453500.0 False True 1933756.287117778 1586109.0345768323 1757420.1297753225 1.0 0.8202217855182224 0.9088115919688717 20.882974551562878 -10.121182290598345 4.490416945979409 1.0000149346664267 0.8645166887392832 0.7571919148951423 0.0361666370532477 50455807.19244891 0.33736014199010106 7999.076464331562 0.01238080183690303 7.565152889340888e-11 10.121182290598345 -0.13549824592714343 LGSALSWSIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGSALSWSIR 10 0 J3KT10;Q9BW27;Q9BW27-3;J3QL54;F5H0W7;J3QLD4;Q9BW27-2;J3QLH0 J3KT10 NUP85 Nuclear pore complex protein Nup85 0 5952200.0 1567300.0 2101200.0 2283700.0 False True 2054745.477754789 1787709.1504134482 2047404.6307972407 1.0 0.8700392188558896 0.9964273692109207 20.970528267015798 -10.701450385137518 7.3363019973188806 1.0004308338465397 0.933233294033922 0.2711838867983202 0.051597746317331106 0.000365924132570006 1.4891142504367036e-05 0.050279128810102186 0.016653101015738206 1.9886099810821373e-11 10.701450385137518 -0.06719753981261778 LGSALSWSIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGSALSWSIR 10 0 J3KT10;Q9BW27;Q9BW27-3;J3QL54;F5H0W7;J3QLD4;Q9BW27-2;J3QLH0 J3KT10 NUP85 Nuclear pore complex protein Nup85 0 4696390.0 1908800.0 622490.0 2165100.0 False True 1848206.1888242948 871053.5032424647 1597995.3583922682 1.0 0.4712967138133926 0.8646196339212596 20.817694284411857 -10.338514879316266 6.0466776035565495 1.0000332204514006 0.6679581738673303 0.48723828464561836 0.16057340973429227 7.191848222931679e-05 7.86752825560648e-06 0.15549005524969836 0.05182484514538767 4.5865393163627404e-11 10.338514879316266 -0.3320750465840704 LGSALSWSIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGSALSWSIR 10 0 J3KT10;Q9BW27;Q9BW27-3;J3QL54;F5H0W7;J3QLD4;Q9BW27-2;J3QLH0 J3KT10 NUP85 Nuclear pore complex protein Nup85 0 5374800.0 1908800.0 1099200.0 2366800.0 False True 1587251.7741777757 1093278.3914258815 2861686.937153238 1.0 0.6887870022966073 1.8029193501047696 20.598099559846133 -6.832146463793124 1.3182083506448297 0.8339361811701089 1.8342533229157532 0.9101121332792091 0.1407250314478013 0.17817929445876252 0.6047555150917165 0.0837982912836809 0.19284914284890098 1.471816055609266e-07 6.832146463793124 1.0003171417456442 LGSALSWSIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGSALSWSIR 10 0 J3KT10;Q9BW27;Q9BW27-3;J3QL54;F5H0W7;J3QLD4;Q9BW27-2;J3QLH0 J3KT10 NUP85 Nuclear pore complex protein Nup85 0 14336200.0 2677200.0 6331400.0 5327600.0 False True 3465688.175501607 5979052.0242521055 4358031.465792267 1.0 1.725213499159291 1.2574793937315225 21.724710423506266 -10.262827438282681 4.687675162690945 0.9998279073543291 1.4913464464468527 0.5953630276024109 0.19095164893748598 0.000343554194961827 5.4026917779877806e-05 0.18495224441588742 0.06162937968810941 5.4597475453613085e-11 10.262827438282681 0.4915185390925235 LGSCK(ub)LIEEVMIGEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGSCKLIEEVMIGEDK 16 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 8851100.0 1577700.0 4889600.0 2383800.0 True False 2068379.9784685348 4160090.739511519 2137147.243024244 1.0 2.0112797371939966 1.0332469204264034 20.98006981430745 -6.63836439773822 2.0501083596397027 1.6621339347486168 1.0372830963183524 0.14842259660031842 0.43287321884900426 0.537537439596351 4.315763204825238 0.17205612850959198 0.479409773701337 2.299511586901689e-07 6.63836439773822 -0.6248508384302645 LGSCK(ub)LIEEVMIGEDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGSCKLIEEVMIGEDK 16 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 42792600.0 9490600.0 13929000.0 19373000.0 True False 14397934.055798298 11443261.12222628 15543918.058512459 1.0 0.7947849377472235 1.0795936415789218 23.779358479956855 -6.7133247115480055 1.7830069560482915 0.8742736062327455 1.0790031888356864 0.48106669573168903 0.08643254602513564 0.36841584218335527 2.2850370558494126 0.03854439572812323 0.09754082700826541 1.9349746888902728e-07 6.7133247115480055 0.20472958260294083 LGSCK(ub)LIEEVMIGEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGSCKLIEEVMIGEDK 16 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 8223500.0 1577700.0 3145600.0 3500200.0 True False 2161018.3257393637 3006616.9908918375 2673524.848881798 1.0 1.3912963879485676 1.2371597302244473 21.04327987583034 -10.211570377773116 5.370545439889192 0.9999816790558622 1.3142280590865558 0.8471267160925042 0.06292602701385586 1.3804572578980362e-05 2.026650206499402e-06 0.06093141328726984 0.020309287888947206 6.143694645683681e-11 10.211570377773116 0.3142463800306936 LGSCK(ub)LIEEVMIGEDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGSCKLIEEVMIGEDK 16 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 11162000.0 5009600.0 2778400.0 3374000.0 True False 4165704.3629091526 2763432.2077307785 4079487.80038661 1.0 0.6633769386843654 0.9793032450189689 21.990129025289576 -10.530834657536069 8.77228566922572 1.0000136890936586 0.8213400922134568 0.2989363937771533 0.12897637447366458 3.453281409990699e-05 1.8469850614110496e-06 0.12489039632512071 0.041626945865892884 2.945542832969163e-11 10.530834657536069 -0.1786735968802018 LGSCK(ub)LIEEVMIGEDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGSCKLIEEVMIGEDK 16 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 40273600.0 9490600.0 11376000.0 19407000.0 True False 12285768.787694458 10742915.599692302 15875125.132635793 1.0 0.8744194836592162 1.2921556157345617 23.550484802049304 -6.826098226596164 1.3452198494272491 0.932696301619909 1.3025294144724504 0.8978508308369856 0.055931761340493866 0.18567478461578663 0.658479203526953 0.03265764527230165 0.07517928736782092 1.492456814839208e-07 6.826098226596164 0.3698331128525414 LGSGPDGAEEIK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGSGPDGAEEIKR 13 1 E9PGT3;Q15418;Q15418-4;Q15418-2;Q15418-3 E9PGT3 RPS6KA1 Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1 1 6219000.0 2093600.0 2100600.0 2024800.0 True False 2744729.8744512424 1787198.6680746698 1815293.1192530803 1.0 0.65113827218862 0.6613740521974004 21.388232741153633 -9.96590725031529 4.967864021577104 1.0000021379231436 0.6562561621892443 0.9993354228206898 0.004178739719588644 5740291.428937463 0.9701177770258429 164.55805460898029 0.0014304937494687721 1.0816649313667178e-10 9.96590725031529 -0.3437459757338993 LGSGPDGAEEIK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGSGPDGAEEIKR 13 1 E9PGT3;Q15418;Q15418-4;Q15418-2;Q15418-3 E9PGT3 RPS6KA1 Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1 1 10319800.0 2072200.0 3054800.0 5192800.0 True False 2006419.145264932 4274597.570571549 3832649.8993392303 1.0 2.13046091623449 1.910194043146034 20.936191588848192 -10.167230903486429 4.5825673393804465 0.9998442173493216 2.020327479704562 0.966227751281528 0.08992357443296352 0.00014314236622291285 2.6012718770557705e-05 0.08708117763790331 0.029022708843984637 6.80407506897778e-11 10.167230903486429 1.0204832623552402 LGSGPDGAEEIK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGSGPDGAEEIKR 13 1 E9PGT3;Q15418;Q15418-4;Q15418-2;Q15418-3 E9PGT3 RPS6KA1 Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1 1 24861800.0 3636200.0 5655600.0 15570000.0 True False 5516381.241828089 4646313.9925955115 12492582.675426586 1.0 0.8422757218744651 2.26463366612541 22.39529073551042 -6.879380410594521 1.083205454456789 0.9030141496870607 2.364262653287829 0.9731841083478664 0.1042459670033109 0.12818236955135243 0.2755904896585744 0.07417320911172967 0.1790973622116683 1.3201387813896337e-07 6.879380410594521 1.461248503600768 up LGSGPDGAEEIK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGSGPDGAEEIKR 13 1 E9PGT3;Q15418;Q15418-4;Q15418-2;Q15418-3 E9PGT3 RPS6KA1 Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1 1 6594800.0 2093600.0 1972000.0 2529200.0 True False 2867660.497412646 1884870.519468049 1931855.05050907 1.0 0.65728510092763 0.6736693734324866 21.451442802676524 -10.318721173644427 8.618254339903311 1.000000449771018 0.6654772371846333 0.998204092730553 0.00668885124060175 5.780377295193192e-08 4.568770166813756e-09 0.006476461050116103 0.0021588174550091223 4.8004154667393296e-11 10.318721173644427 -0.33452321258638473 LGSGPDGAEEIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGSGPDGAEEIKR 13 1 E9PGT3;Q15418;Q15418-4;Q15418-2;Q15418-3 E9PGT3 RPS6KA1 Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1 1 9123800.0 2072200.0 4478900.0 2572700.0 True False 1723126.114025139 4454771.276707961 3110639.6751792026 1.0 2.5852845247071508 1.8052304180527443 20.71659686428247 -10.305803961242686 5.353712122189921 0.9997704191184789 2.1952574713800104 0.7578979288667624 0.3184557555111979 0.0008728132005662738 0.0001131742734225011 0.308400171280101 0.10278115313319898 4.945338671817972e-11 10.305803961242686 1.1954870522615315 LGSIAIQGAIEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGSIAIQGAIEK 12 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;H0YEL7;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 94243000.0 24271000.0 32530000.0 37442000.0 False True 31819516.040698357 27676650.800946873 33567861.00902499 1.0 0.8698011234849516 1.0549456806976711 24.923408557360254 -6.717724874753091 1.7675414805097065 0.9205958950405916 1.05461982029938 0.5017183757137909 0.05480411619732171 0.35976862326726256 2.195397799735032 0.02463119785146131 0.06199867434772583 1.9154689889917658e-07 6.717724874753091 0.13402392525878837 LGSIAIQGAIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGSIAIQGAIEK 12 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;H0YEL7;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 72637000.0 22352000.0 14739000.0 35546000.0 False True 21642447.9948662 20624359.562869594 26235436.242857877 1.0 0.9529587211096403 1.2122212907283492 24.367360357013453 -6.859932882158267 1.186131949864722 0.974483435838015 1.2247565149002846 0.953554389945129 0.024304842428098786 0.14686906000608518 0.3926857504488879 0.015982742865395982 0.03730425226547035 1.3805976119420413e-07 6.859932882158267 0.2502730790622696 LGSIAIQGAIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGSIAIQGAIEK 12 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;H0YEL7;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 180219000.0 31191000.0 94394000.0 54634000.0 False True 47319027.36754312 77548653.19631168 43835565.953067094 1.0 1.6388471511462965 0.9263834950068016 25.495917083906917 -6.6703488395087485 1.9360152250979232 1.4076515138250432 0.9292534416150452 0.28061474042108514 0.27134672290777034 0.4603366420637313 3.326735857133862 0.11281767232002013 0.3012968074612928 2.136245498045175e-07 6.6703488395087485 -0.47839807220999797 LGSIAIQGAIEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGSIAIQGAIEK 12 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;H0YEL7;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 83367000.0 24271000.0 30554000.0 28542000.0 False True 33244644.599112682 29204023.25143346 21800967.440941762 1.0 0.8784579773252541 0.6557738157177846 24.986618618883146 -6.961722152165016 0.41044179298408173 1.0109168762857692 0.515044928565249 0.9998288329739072 0.0018648203843018953 0.07909157740286081 0.018899821060693985 0.0028678173004136405 0.018589811131182434 1.0921388287715472e-07 6.961722152165016 -0.49587194772052023 LGSIAIQGAIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGSIAIQGAIEK 12 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;H0YEL7;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 52969000.0 22352000.0 15346000.0 15271000.0 False True 18586678.361494977 15263328.052057503 18464095.4948737 1.0 0.8211971905468445 0.993404799704544 24.14776563244773 -10.643499421830125 7.9680393145077675 1.0001338025682485 0.9073009951295703 0.27868295089623474 0.0703034620434999 0.000167347190898859 7.487331288610628e-06 0.06816888512604267 0.0226903448062667 2.272482660591672e-11 10.643499421830125 -0.09283280743867817 LGSIAIQGAIEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGSIAIQGAIEK 12 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;H0YEL7;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 136355000.0 31191000.0 62637000.0 42527000.0 False True 40377364.366528764 59151195.88765182 34787522.36386887 1.0 1.4649593111304169 0.8615600079312346 25.267043405999367 -6.700898367906612 1.8276261186446605 1.288466429509923 0.8633222621955869 0.42185278948690486 0.19623302302063592 0.3936610025820053 2.5569923119046036 0.08563696146435626 0.21999500489656007 1.9911392439932387e-07 6.700898367906612 -0.42514416731433613 LGSIFGLGLAYAGSNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGSIFGLGLAYAGSNR 16 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 54091190.0 16194000.0 27203190.0 10694000.0 False True 21230490.8229191 23144580.08920411 9587487.464091487 1.0 1.090157560757789 0.4515904763606049 24.33963438918097 -6.871144399660784 1.1280923794544193 1.0513550223218877 0.4133815105184266 0.9658086125669617 0.05217836291977432 0.13575879327430612 0.3222093192582158 0.03587242560673431 0.08509796867678994 1.345412939958665e-07 6.871144399660784 -0.6379735118034611 down LGSIFGLGLAYAGSNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGSIFGLGLAYAGSNR 16 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 128141000.0 45528200.0 42838000.0 39774800.0 False True 44082932.21187674 59943436.79721878 29356586.66157718 1.0 1.359787876838849 0.6659399724247014 25.393716853339296 -6.765781974294109 1.5906602678210549 1.207474267463831 0.6626495554350805 0.7141500723830305 0.1514806626541454 0.27330282885122975 1.3640419952172358 0.07509476509495307 0.17945294284157512 1.7148179690704155e-07 6.765781974294109 -0.5448247120287505 LGSIFGLGLAYAGSNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGSIFGLGLAYAGSNR 16 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 112231630.0 16194000.0 32901630.0 63136000.0 False True 22181359.426394917 31447927.195459254 48224577.12673604 1.0 1.4177637443644457 2.174103768831713 24.40284445070386 -6.961944417088675 0.4071044232769785 0.961544823394778 2.658259327920915 0.9998356541873297 0.006229414108979696 0.07901371342402289 0.018617726720782622 0.009733113407354391 0.06320920954690669 1.0915800327061242e-07 6.961944417088675 1.696714504526137 up LGSIFGLGLAYAGSNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGSIFGLGLAYAGSNR 16 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 88172200.0 45528200.0 19281000.0 23363000.0 False True 37858715.541240916 19177129.42602117 28248095.281693045 1.0 0.5065446397707499 0.746145104973816 25.174122128773572 -10.089070560900351 5.164610857020081 1.0000073769156375 0.6263448723715729 0.7643004301277933 0.09781648031597644 136030086.24592206 0.18465508354005142 11933.350265828092 0.03348518297763474 8.145719277499665e-11 10.089070560900351 -0.3736625045440646 LGSLVDEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGSLVDEFK 9 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 7251800.0 2137200.0 1427900.0 3686700.0 False True 2069355.755844136 1998067.9164001313 2721042.6713707345 1.0 0.9655507085996797 1.3149226099408706 20.980750258539405 -6.882664706042263 1.064873788455851 0.9777959743359128 1.3409783837510019 0.9757701011448031 0.024470626775477403 0.12529374635873483 0.2582700805096348 0.017657915312176278 0.04300389851273341 1.3101930578365904e-07 6.882664706042263 0.36318240941508906 LGSPDYGNSALLSLPGYRPTTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGSPDYGNSALLSLPGYRPTTR 22 1 Q14980;Q14980-2;A0A087WY61;Q14980-5;H0YFY6 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 0 13673500.0 2334500.0 4650500.0 6688500.0 False True 3060552.107330158 3956663.527507022 5996438.180622389 1.0 1.2927940413204002 1.9592668153764328 21.545360500235148 -6.957438378836732 0.4701511319523282 0.9824224382238588 2.2969672816794184 0.9996630614122274 0.007368074898341328 0.08062926282616122 0.024611444909194834 0.00921768684393155 0.05500702422764323 1.1029647201748068e-07 6.957438378836732 1.3145448434555598 LGSPSGK(ub)TGTCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGSPSGKTGTCR 12 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 2338830.0 958670.0 835310.0 544850.0 True False 928237.5455994272 1168853.6390841056 402137.4398503654 1.0 1.2592182298867214 0.433226862840026 19.82413452763831 -6.8223549833670525 1.361640155433365 1.1393944987736182 0.4142653491347948 0.8897163321396567 0.11454225682886088 0.19043940825660627 0.6931425162516005 0.06609294588454752 0.15224742677737244 1.5053760997448783e-07 6.8223549833670525 -0.7251291496388235 down LGSQK(ub)PVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGSQKPVQR 9 1 Q96HA7;Q96HA7-2 Q96HA7 TONSL Tonsoku-like protein 1 3112650.0 167860.0 107090.0 2837700.0 True False 217298.079015277 101130.34736032436 2321267.7172608124 1.0 0.46539917802593395 10.682412508108813 17.729315895125435 -6.894559070710375 0.995044290951902 0.5095078417317594 11.64378205705424 0.9836588146141592 0.6002272830060162 0.11552116119865294 0.20087374208982184 0.45665220619655883 1.1587810060007877 1.274796696248771e-07 6.894559070710375 11.134274215322481 up LGSSGLGSASSIQAAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGSSGLGSASSIQAAVR 17 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 8836900.0 2190900.0 3255600.0 3390400.0 False True 2872291.116705782 2769877.170229404 3039593.931013253 1.0 0.9643441620939049 1.0582471648971814 21.453770548061453 -6.803806148227625 1.4401221604557017 0.9804197596905525 1.0596710905741111 0.8430655587827017 0.01533248384558604 0.21539867132694268 0.8814763787287778 0.00837367042312212 0.01943247006369744 1.571063908251846e-07 6.803806148227625 0.07925133088355862 LGSSGLGSASSIQAAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGSSGLGSASSIQAAVR 17 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 4944310.0 2190900.0 993910.0 1759500.0 False True 3000934.9368462767 949995.7697791542 1343942.338039977 1.0 0.31656660000017117 0.447841211596658 21.516980609584344 -10.042017626932253 6.281881418535266 1.0000005928072055 0.38220390580472374 0.9672456328072325 0.053592635765610866 4.449830067098954e-07 6.782246585580825e-08 0.05189089670619441 0.017296948816625385 9.077836847497676e-11 10.042017626932253 -0.6177966870024818 LGSTVFVANLDYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGSTVFVANLDYK 13 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0QYQ7 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 101924000.0 29691000.0 41369000.0 30864000.0 False True 38925188.52805296 35196906.45509897 27670489.348393466 1.0 0.9042192931122978 0.710863335406883 25.2142006910002 -6.959862145498649 0.43737387516016185 1.0071059655227517 0.6004707912381693 0.999765046014229 0.0018433491220622893 0.07975042743358939 0.021313695775668738 0.002541216680139603 0.016028949742454595 1.0968262973824666e-07 6.959862145498649 -0.4066351742845824 LGSTVFVANLDYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGSTVFVANLDYK 13 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0QYQ7 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 143291000.0 59737000.0 27349000.0 56205000.0 False True 57840681.6333806 38269598.32315087 41483224.38614259 1.0 0.6616380935086525 0.7171980553251656 25.785581218286588 -10.497972129008891 6.1718755917926575 1.0002475840226157 0.689418074416919 0.9765613631607777 0.022682259429828988 7.733366993625892e-05 6.2904281051806126e-06 0.02197923748681138 0.007320667752173637 3.1770779541294205e-11 10.497972129008891 -0.31082950960569666 LGSTVFVANLDYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGSTVFVANLDYK 13 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0QYQ7 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 365880000.0 79100000.0 162900000.0 123880000.0 False True 120000482.98459983 133829222.25649063 99395063.70146707 1.0 1.1152390301101163 0.8282888637558472 26.8384649715834 -6.7976954707097805 1.4651930950691276 1.06376952168979 0.8245444788434999 0.8253714476099367 0.049269023798585575 0.2240629086694561 0.9498488494132142 0.026456124285740446 0.061618592305334285 1.5933255826675582e-07 6.7976954707097805 -0.2392250428462901 LGSTVFVANLDYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGSTVFVANLDYK 13 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0QYQ7 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 110845000.0 29691000.0 35464000.0 45690000.0 False True 40668565.06910524 33897083.216234796 34898963.01508752 1.0 0.833495923906729 0.8581311623802356 25.277410752523092 -10.183670996886656 7.642674809685523 1.0000000889424743 0.8458135431636098 0.9812134945433488 0.010057293991978643 1.5239258288382797e-08 1.6328281221034605e-09 0.009737938693844013 0.003245977678237095 6.551322866114939e-11 10.183670996886656 -0.15418654577886448 LGSTVFVANLDYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGSTVFVANLDYK 13 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0QYQ7 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 104531000.0 59737000.0 21677000.0 23117000.0 False True 49673962.29780898 21560221.698452383 27950657.81906855 1.0 0.4340346672808777 0.562682269062748 25.565986493720864 -9.945947627004752 7.02813576130837 1.0000000196051582 0.49835846817205176 0.9529924984312994 0.05252016349972867 1.6075634842481737e-08 2.479816470067828e-09 0.050852431159148365 0.016950809881211004 1.1325369313419504e-10 9.945947627004752 -0.5016415514331064 LGSTVFVANLDYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGSTVFVANLDYK 13 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0QYQ7 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 293583000.0 79100000.0 129710000.0 84773000.0 False True 102396509.29410467 122491524.47574633 69345183.84443426 1.0 1.1962470724849075 0.6772221467556093 26.609591293675848 -6.804256498862625 1.4384049613501422 1.1077024501070043 0.6692765882968702 0.8443234144460174 0.08442750789561194 0.2147444531971125 0.876664653370205 0.04616524151911144 0.10710051683450487 1.5694356054729472e-07 6.804256498862625 -0.4384258618101341 LGTDESCFNMILATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGTDESCFNMILATR 15 0 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 0 5403600.0 1165700.0 1989100.0 2248800.0 False True 1528243.988654859 1692334.0334510705 2016115.748012801 1.0 1.1073716278384589 1.319236825388962 20.543443461599594 -6.9603079435881385 0.43107276097334346 0.9916795197233943 1.4430680097893227 0.9997814464140695 0.001960804315723292 0.07959132171500813 0.020726290662900108 0.002765558504881236 0.017587031028322982 1.0957009959643825e-07 6.9603079435881385 0.4513884900659284 LGTEK(ub)EVEVIGGADK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGTEKEVEVIGGADK 15 1 P04183 P04183 TK1 Thymidine kinase, cytosolic 1 27672590.0 8510090.0 15972700.0 3189800.0 True False 11156810.401828783 13589635.421096936 2859750.094722184 1.0 1.2180573955858722 0.25632326728913707 23.411421301129984 -6.847111745894886 1.248851063420085 1.1161431176644332 0.21994723940182906 0.936005801403567 0.10415026254104953 0.1606666817188566 0.4836425468605295 0.06530138010139404 0.1508673134612459 1.4219628627014678e-07 6.847111745894886 -0.8961958782626042 down LGTEK(ub)EVEVIGGADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGTEKEVEVIGGADK 15 1 P04183 P04183 TK1 Thymidine kinase, cytosolic 1 31693600.0 16992100.0 9671600.0 5029900.0 True False 16452695.086505275 13533520.316727702 3712418.2962344745 1.0 0.8225716361709079 0.22564195572307486 23.971820592820077 -6.948850303646407 0.5713343846801188 1.007391847469905 0.011733299672280649 0.9991078819782567 0.009893372488758316 0.08395088777778031 0.03789976971253447 0.010465540194664481 0.04975228232895087 1.1249926792872126e-07 6.948850303646407 -0.9956585477976244 down LGTEK(ub)EVEVIGGADK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGTEKEVEVIGGADK 15 1 P04183 P04183 TK1 Thymidine kinase, cytosolic 1 20981700.0 16936000.0 4045700.0 0.0 True False 25693150.187448625 3323713.2258016276 0.0 1.0 0.12936184164078474 0.0 24.614880451343474 -10.334203877400762 0.4256782947393486 1.5205997460617244 8.261966566823994e-22 0.9990295301569057 0.01383368064747617 1.9197221603241137 0.22145639480813797 1.1715674422263538 0.03159292092543424 4.6322940792640477e-11 10.334203877400762 -1.5205997460617244 LGTEK(ub)EVEVIGGADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGTEKEVEVIGGADK 15 1 P04183 P04183 TK1 Thymidine kinase, cytosolic 1 24667090.0 8510090.0 12516000.0 3641000.0 True False 11656500.24953494 11963001.735122796 2781070.788748825 1.0 1.0262944690967672 0.2385854012107778 23.474631362652875 -6.899174944174132 0.9664437778484579 1.0334955893432247 0.15726634534564018 0.9861520826228315 0.04298626081608471 0.11201602159678052 0.18085374620701883 0.03340967550201045 0.0865743643601106 1.2613193427311244e-07 6.899174944174132 -0.8762292439975845 down LGTEK(ub)EVEVIGGADK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGTEKEVEVIGGADK 15 1 P04183 P04183 TK1 Thymidine kinase, cytosolic 1 33079100.0 16992100.0 13011500.0 3075500.0 True False 14129684.027664583 12941404.466919469 3718572.8304946683 1.0 0.9159019013858642 0.2631745213278694 23.752225868254353 -6.930663572161238 0.7413244637588283 1.009685597673719 0.126879844727823 0.9966670710584491 0.019011875516304684 0.09229473445222622 0.076002759505135 0.01738959861811177 0.058846541245091526 1.1731037628573756e-07 6.930663572161238 -0.8828057529458959 down LGTEK(ub)EVEVIGGADK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGTEKEVEVIGGADK 15 1 P04183 P04183 TK1 Thymidine kinase, cytosolic 1 31331000.0 16936000.0 4208000.0 10187000.0 True False 21923985.85846978 3973821.1008707173 8333070.527446833 1.0 0.18125450027762774 0.380089212848473 24.386006773435923 -10.891052730292298 11.110284487384979 1.0443089941846235 0.2806718565630505 0.9458009919766848 0.08117393149192116 0.04139878010378603 0.0004059550080485145 0.036521952647066626 0.02619877373453269 1.2851306150711609e-11 10.891052730292298 -0.763637137621573 LGTEK(ub)EVEVIGGADKYHSVCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGTEKEVEVIGGADKYHSVCR 21 2 P04183 P04183 TK1 Thymidine kinase, cytosolic 1 35640100.0 15431000.0 5300100.0 14909000.0 True False 23409955.157210637 4354255.745129691 11962229.615153167 1.0 0.1860001745363665 0.5109890016798521 24.480618835118882 -10.535129429295708 6.27736971065043 1.0007865993581209 0.34849458814719203 0.8427285846834145 0.1326761331011839 0.0014621554239511228 0.00010828011788854706 0.128601509706557 0.04282103782834029 2.9165576862100094e-11 10.535129429295708 -0.6522920112109288 LGTEK(ub)EVEVIGGADKYHSVCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGTEKEVEVIGGADKYHSVCR 21 2 P04183 P04183 TK1 Thymidine kinase, cytosolic 1 51377200.0 15431000.0 7122200.0 28824000.0 True False 19975733.69048458 6725843.309083024 23578327.759215433 1.0 0.3367006896115597 1.180348523090641 24.25174515721133 -6.697070257180601 1.8416315131662178 0.5869358220781989 1.1776806639262765 0.40357516886543443 0.2801400652104291 0.4016308296518983 2.6462394199285524 0.12145880644578282 0.3134581431358589 2.0087678216505658e-07 6.697070257180601 0.5907448418480775 LGTLFAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGTLFAFK 8 0 Q6F5E8-2;Q6F5E8 Q6F5E8-2 RLTPR Leucine-rich repeat-containing protein 16C 0 2282460.0 687430.0 687750.0 907280.0 False True 901227.3870815894 585140.3808285034 813403.3688442982 1.0 0.6492705273009305 0.9025506553660243 19.781531630227686 -10.544126342219426 5.24221087117923 1.0009133463254627 0.7759105913334762 0.5106933946639058 0.10340117929104706 0.0011081305927989591 9.63652740101136e-05 0.10051360518550125 0.03337258711436876 2.856759352013607e-11 10.544126342219426 -0.22500275499198652 LGTLSALDILIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGTLSALDILIK 12 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 5081900.0 1443400.0 2400900.0 1237600.0 False True 1892311.3779054824 2042695.0786348998 1109545.0238974756 1.0 1.0794709065776853 0.5863437893215983 20.85171807153131 -6.86561137435035 1.1571298563104397 1.0439451490705771 0.5597821899143844 0.9600995394224703 0.04318203183879189 0.14112831322115788 0.35594847941615215 0.0290337155354643 0.06825800220969373 1.3626635078121537e-07 6.86561137435035 -0.4841629591561927 LGTLSALDILIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGTLSALDILIK 12 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 15855800.0 6577100.0 5187600.0 4091100.0 False True 6368313.560622519 7259035.732976625 3019518.179630784 1.0 1.139867825896914 0.47414722137765125 22.602479941829177 -6.851850249536242 1.2262168426926967 1.0747703342813093 0.44658241993481 0.9429419782449666 0.0684601860980838 0.15543536554522674 0.4488277414572186 0.04366677308095763 0.10116876850845309 1.4065324314521135e-07 6.851850249536242 -0.6281879143464992 down LGTLSALDILIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGTLSALDILIK 12 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 23306300.0 4085300.0 11789000.0 7432000.0 False True 6197698.775435983 9685160.842122594 5963061.942438676 1.0 1.5627027374271318 0.9621412976817671 22.56330120715484 -8.722467590560338 18.253390455405444 0.9999890536675063 1.2624220175545813 0.20292053839833324 0.24517818117602086 0.0 0.0 0.2373927531002311 0.07913091770007702 1.8946648993825614e-09 8.722467590560338 0.26243296388707493 LGTLSALDILIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGTLSALDILIK 12 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 11538700.0 1443400.0 2108900.0 7986400.0 False True 1977063.9864183266 2015721.8248002927 6100176.805071029 1.0 1.0195531549042067 3.085472623535156 20.9149281330542 -6.908971274669434 0.9027101345148819 0.9339353467569781 3.3466670578654454 0.9905275744472706 0.09523630825080766 0.10510226342791479 0.14248569295039668 0.07757680304321528 0.212651514813796 1.2331863965848514e-07 6.908971274669434 2.412731711108467 up LGTLSALDILIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGTLSALDILIK 12 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 11720200.0 6577100.0 2030600.0 3112500.0 False True 5469150.0649332795 2019660.7547574572 3763309.3594260006 1.0 0.36928238040257466 0.6880976595532328 22.382885217263453 -10.569341565821968 6.523122682280475 1.0007312549783751 0.5286900199779901 0.7444999811250459 0.13015579268701544 0.001386150774554078 9.151400249548443e-05 0.12620305983874794 0.04200760145743635 2.6956185366821377e-11 10.569341565821968 -0.472041235000385 LGTLSALDILIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGTLSALDILIK 12 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 15195400.0 4085300.0 6780700.0 4329400.0 False True 5288501.3833022285 6403348.08428566 3541493.623395342 1.0 1.2108057879125111 0.6696592033760562 22.33442752924729 -6.801049966301307 1.4515256912850378 1.1161566794082391 0.6619855707225625 0.8352433962963097 0.09039909363166776 0.2192606195019071 0.911908045852678 0.04899089784887817 0.11386759254597396 1.5810661245227334e-07 6.801049966301307 -0.45417110868567667 LGTQEYLQQLESHMK(ub)SR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGTQEYLQQLESHMKSR 17 1 Q6P2E9;Q6P2E9-2;I3L2F4 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 49802000.0 19183000.0 19910000.0 10709000.0 True False 29102013.465152737 16356904.942459967 8592361.456078555 1.0 0.5620540641301679 0.29524972443460656 24.794615635754084 -8.645730900277007 0.20160544001718472 1.3346159190477909 5.1806321764196123e-20 0.9996621226965693 0.005340303732712082 0.22999960924242704 0.055697565639681756 0.17704968339883162 0.12999824441478475 2.2608362069622686e-09 8.645730900277007 -1.3346159190477909 down LGTQEYLQQLESHMK(ub)SR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGTQEYLQQLESHMKSR 17 1 Q6P2E9;Q6P2E9-2;I3L2F4 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 17078500.0 5140300.0 7590200.0 4348000.0 True False 7040807.821384326 7254839.866565119 3321091.949870881 1.0 1.0303987909641186 0.47169189020953933 22.747309534130586 -6.894041504640197 0.9981982584594663 1.0271766812422805 0.41965923875564953 0.9833605275782443 0.033088564769745255 0.11592411223037784 0.203197370974033 0.025114267757822148 0.06359147174224218 1.2763168279797312e-07 6.894041504640197 -0.607517442486631 down LGTQEYLQQLESHMK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGTQEYLQQLESHMKSR 17 1 Q6P2E9;Q6P2E9-2;I3L2F4 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 28257000.0 8076600.0 14578000.0 5602400.0 True False 6716050.75404664 14499465.420493545 6773835.93742915 1.0 2.1589273147998687 1.0086040420923996 22.679181702269563 -6.64445770151832 2.028581293310374 1.7552925156700239 1.0134327448743587 0.17189641703526226 0.4953203663180358 0.5221668730983372 4.11219165449568 0.19847760298550135 0.5484552167537684 2.2674739089473112e-07 6.64445770151832 -0.7418597707956651 LGTQEYLQQLESHMK(ub)SR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LGTQEYLQQLESHMKSR 17 1 Q6P2E9;Q6P2E9-2;I3L2F4 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 64966500.0 26039100.0 23125800.0 15801600.0 True False 33708128.2573973 21838828.900787998 12925870.938107796 1.0 0.6478802007048681 0.3834645115683987 25.0065931838878 -7.767287818673299 0.19343491121305573 1.236607135214002 4.955214132211681e-14 0.9999108019681202 0.00238516609975896 0.12838887784568453 0.026268644473261167 0.05565646374649246 0.0883596834092982 1.708882417235891e-08 7.767287818673299 -1.2366071352139525 down LGVDLDAQTWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGVDLDAQTWR 11 0 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 26843700.0 7083300.0 11054000.0 8706400.0 False True 9169471.48271722 10438835.182753058 7121924.535207927 1.0 1.1384336820751728 0.7766995675412105 23.128407150337857 -6.8029591501423265 1.4436641368720964 1.0760950270536858 0.7713253081264847 0.8407205119339318 0.059475999650999006 0.2165535895539334 0.8906882271690176 0.03240485937958218 0.07523470500471344 1.574130920687663e-07 6.8029591501423265 -0.30476971892720106 LGVENCYFPMFVSQSALEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGVENCYFPMFVSQSALEK 19 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 2765120.0 624120.0 1522700.0 618300.0 False True 818227.3639866784 1295519.0954381106 554324.2471524003 1.0 1.5833240887054996 0.6774697004162101 19.642142260535593 -6.7328348576448445 1.7128225713553178 1.3499379024575389 0.6777205748352382 0.5723159124819444 0.2451672027688301 0.33098646903853907 1.9035848238952193 0.11336887765287612 0.28042647451401337 1.8499719450818288e-07 6.7328348576448445 -0.6722173276223007 LGVENCYFPMFVSQSALEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGVENCYFPMFVSQSALEK 19 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 5375720.0 624120.0 1461600.0 3290000.0 False True 854874.030208818 1397021.6791351442 2512969.759676912 1.0 1.634184253782861 2.939579015007714 19.705352322058484 -6.959478073763221 0.44272734744903963 0.9546299291442476 3.6702600249531994 0.9997503516684562 0.012758391624134918 0.07988808404056005 0.021824123723714856 0.017270921100904373 0.10810594343464096 1.0977967133657865e-07 6.959478073763221 2.715630095808952 LGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLK 35 0 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 266925000.0 186935000.0 53383900.0 26606100.0 False True 181000850.7480457 74700369.66336086 19637164.244109027 1.0 0.41270728482566216 0.10849211019148236 27.431421237441093 -8.742761700016663 0.32952238127195993 1.1793611960401063 3.540232373456862e-19 0.9982282077286481 0.015575206451120678 0.30055119685477777 0.1056348681289927 0.15531012698580018 0.08889063394655995 1.808166005377752e-09 8.742761700016663 -1.1793611960401063 LGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLK 35 0 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 967211000.0 254278000.0 355936000.0 356997000.0 False True 385758316.2118598 292416439.8593388 286436386.4726562 1.0 0.7580301644067284 0.7425280919033883 28.523122017977304 -13.999999999999998 0.3906530436461159 4.841769802049189 0.7414128783816392 0.9998241227432345 0.0015634254051571667 25.4392110762284 0.20494488404593278 82.54512380535216 0.004072388456489059 1.0000000000000041e-14 13.999999999999998 -4.10035692366755 LGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLK 35 0 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 11258100.0 2421800.0 4180300.0 4656000.0 False True 3317204.906684152 3995600.523596497 3556348.6933299955 1.0 1.2045082037426693 1.0720919549359071 21.66153670075267 -10.042145273059653 4.450276076198574 0.9999924472761266 1.1383000792565825 0.59257798890933 0.05405870725109393 6137635.716403142 13861509.218128566 244.14971484013105 0.018505733242953355 9.075169117429763e-11 10.042145273059653 0.13830763198045593 LGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLK 35 0 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 357936300.0 186935000.0 38143300.0 132858000.0 False True 155444735.1246451 37937814.472047776 160637993.53401405 1.0 0.24405982255768852 1.033409033797154 27.21182651287537 -10.15027238463184 13.702045120065828 0.9999999288412008 0.6387344281774212 0.21831568032475945 0.32225046606751306 0.0 0.0 0.3120176720967629 0.10400589069892095 7.075019079339545e-11 10.15027238463184 -0.3612655006637796 LGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLK 35 0 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 565904300.0 254278000.0 177192000.0 134434300.0 False True 329167883.5687279 167331109.4357138 109968636.8124027 1.0 0.5083457949225361 0.3340806995511214 28.294248340069753 -13.999999999999996 0.14449797023619965 3.3595413770644607 0.12967346853830927 0.9995856263440255 0.00573973396727758 11.941277305244624 0.11940581579093984 7.9268724265729675 0.1833453458818872 1.0000000000000082e-14 13.999999999999996 -3.2298679085261512 LGVIEDHSNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGVIEDHSNR 10 0 P14625;Q58FF3 P14625 HSP90B1;HSP90B2P Endoplasmin;Putative endoplasmin-like protein 0 26902010.0 897010.0 12920000.0 13085000.0 False True 1175988.796657197 10992386.361765556 11731089.720183 1.0 9.347356363438093 9.975511461953694 20.165442885379324 -9.658631057985628 0.7029545315005344 9.443248969270218e-20 9.871466646333994 0.9994330270285098 0.0974136048298085 0.9593990688147432 0.34268922404284813 2.6460790863905097 0.09712580214381171 2.194668559319006e-10 9.658631057985628 9.871466646333994 LGVIEDHSNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGVIEDHSNR 10 0 P14625;Q58FF3 P14625 HSP90B1;HSP90B2P Endoplasmin;Putative endoplasmin-like protein 0 24307500.0 6634000.0 2416500.0 15257000.0 False True 6423407.301268003 3381421.0518810274 11260733.999811005 1.0 0.5264217094272573 1.7530779960953273 22.614907348392013 -6.802005724153822 1.4475090161872384 0.7393697982955675 1.7709042167287024 0.8380364102481827 0.2032739632992961 0.21789275772045966 0.9010843139601972 0.11046114369511577 0.2566076566788315 1.5775904763656947e-07 6.802005724153822 1.031534418433135 LGVIEDHSNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGVIEDHSNR 10 0 P14625;Q58FF3 P14625 HSP90B1;HSP90B2P Endoplasmin;Putative endoplasmin-like protein 0 26815010.0 897010.0 13118000.0 12800000.0 False True 1228658.8377837774 12538403.384575006 9776903.624274911 1.0 10.204951121493945 7.9573786665712944 20.228652946902216 -9.653380041653527 8.175578076116235 1.0000000002158749 9.0811648950571 0.9451661323237762 0.9175676124159401 0.0 0.0 0.8884310204765147 0.2961436734921715 2.221365171546483e-10 9.653380041653527 8.081164894841224 LGVLYWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGVLYWK 7 0 Q9BV57 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 0 38707800.0 9067800.0 10379000.0 19261000.0 False True 11887973.612700108 8830493.657025132 17268056.484558243 1.0 0.7428089887069885 1.452565176129808 23.502999482906862 -6.808646245531757 1.420033349512645 0.8596089776954714 1.4646247109702968 0.8563244702891104 0.11120939938093653 0.20864101202045773 0.8294330339087571 0.06158162336474178 0.1425524060125328 1.553652021569987e-07 6.808646245531757 0.6050157332748254 LGVLYWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGVLYWK 7 0 Q9BV57 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 0 25791400.0 9359800.0 3556600.0 12875000.0 False True 9062678.27229549 4976768.927423983 9502651.258279255 1.0 0.5491499066713988 1.0485477882767567 23.111506038928294 -6.668888485614995 1.941152528792557 0.7119522289863067 1.0465266423877275 0.27419339974389545 0.1915600284141178 0.4636792670079289 3.367274289866293 0.07947304194507496 0.21265273580277122 2.1434409047033292e-07 6.668888485614995 0.3345744134014208 LGVLYWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGVLYWK 7 0 Q9BV57 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 0 12454500.0 5153800.0 4624600.0 2676100.0 False True 7818691.393249454 3799303.9978352776 2147167.662023701 1.0 0.4859258163220948 0.2746198249847199 22.89849573459972 -12.462568803337296 0.14192427984426292 2.611968448335513 7.309281333253615e-23 0.9996303319188239 0.005856706536709666 6.670420232516907 0.10294889285185987 3.312903458032703 0.22243393348795376 3.446919942323602e-13 12.462568803337296 -2.611968448335513 LGVLYWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGVLYWK 7 0 Q9BV57 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 0 29968800.0 9067800.0 8171000.0 12730000.0 False True 12420410.70808099 7809978.202116351 9723436.182579646 1.0 0.6288019281870453 0.7828594730972436 23.566209544429753 -10.135374846704982 5.2100562904925445 1.000009201351568 0.7058307018508962 0.829394290436521 0.062893729343548 6.722315975698919e-06 1.115621763212679e-06 0.06089849556002721 0.02029886386057365 7.321922931279662e-11 10.135374846704982 -0.29417849950067176 LGVLYWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGVLYWK 7 0 Q9BV57 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 0 20269600.0 9359800.0 5589100.0 5320700.0 False True 7783088.409445275 5558990.408950505 6433233.769862779 1.0 0.7142396586686995 0.8265656807978231 22.89191131436257 -10.080009796841754 4.651938342441406 1.0000120475560612 0.7704026697274453 0.8478097684796075 0.04585690652858333 11187385.198160779 24241282.55414713 825.6653943206916 0.015698041309335786 8.317450083357619e-11 10.080009796841754 -0.2296093778286159 LGVLYWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGVLYWK 7 0 Q9BV57 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 0 18795400.0 5153800.0 7769700.0 5871900.0 False True 6671695.696586064 7337309.364884788 4803274.450781886 1.0 1.0997667907184858 0.7199480715584409 22.66962205669217 -6.836887005521806 1.2966518916810066 1.0531157169418668 0.7081969934394169 0.9189842424190405 0.04576254019236041 0.17246967395641688 0.5645985804005544 0.027686538257514763 0.06374534361739444 1.4558378103205502e-07 6.836887005521806 -0.3449187235024499 LGVNNISGIEEVNMFTNQGTVIHFNNPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGVNNISGIEEVNMFTNQGTVIHFNNPK 28 0 P20290;P20290-2 P20290;P20290-2 BTF3 Transcription factor BTF3 0 28850700.0 15788000.0 3977800.0 9084900.0 False True 15286818.58191426 5566156.283952963 6705292.148842039 1.0 0.3641147603163321 0.4386322839452696 23.865784855497093 -10.485804982453445 6.167501413777826 1.0004035129011142 0.40137352213281907 0.9885119011228728 0.030421651631114363 0.00016889998359584558 1.408143948969378e-05 0.02947451870031956 0.009818545844285789 3.26734517572364e-11 10.485804982453445 -0.5990299907682951 LGVQQSLGWVHYMIHEPEPHILLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGVQQSLGWVHYMIHEPEPHILLFR 25 0 P33552 P33552 CKS2 Cyclin-dependent kinases regulatory subunit 2 0 31859500.0 8510000.0 5603500.0 17746000.0 False True 12910292.164335594 4603511.644654669 14238495.321651898 1.0 0.3565768757249175 1.1028794035339833 23.62201831390921 -6.67861730700181 1.9069601142403223 0.5923875826727406 1.0999969960837137 0.31771815599841524 0.27278202519191375 0.44161297011073075 3.103732085485575 0.11483602207966503 0.30339207749550107 2.0959585658119547e-07 6.67861730700181 0.5076094134109731 LGVQQSLGWVHYMIHEPEPHILLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGVQQSLGWVHYMIHEPEPHILLFR 25 0 P33552 P33552 CKS2 Cyclin-dependent kinases regulatory subunit 2 0 35741000.0 8510000.0 10100000.0 17131000.0 False True 11016362.757178653 9537926.121386465 14013333.778903695 1.0 0.8657963006139402 1.272047234444246 23.393144636001658 -6.817677381551461 1.3817510693612058 0.9274863880380233 1.2804906975629076 0.8789635778390579 0.05879686386832362 0.19653562490964646 0.7379092612099635 0.03344245963616315 0.07713662535175253 1.5216774978926737e-07 6.817677381551461 0.35300430952488426 LGVQVVITDPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGVQVVITDPEK 12 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 6008800.0 2119600.0 2410800.0 1478400.0 False True 2778816.126235597 2051118.0372248003 1325429.3498141812 1.0 0.7381265776672336 0.4769762696064789 21.406038944148932 -6.971159443699844 0.2288054534574725 1.1078084575683893 0.09984321980584458 0.9999900670470853 0.0006729287941982315 0.07592824976401923 0.007670393228608478 0.006769622515833757 0.025997945477450535 1.068662466271123e-07 6.971159443699844 -1.0079652377625448 down LGVQVVITDPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGVQVVITDPEK 12 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 18470800.0 6060000.0 5309500.0 7101300.0 False True 5867628.617076292 7429611.038676726 5241256.495566485 1.0 1.2662033546320004 0.8932495284914754 22.484346129964305 -6.715035470356828 1.776952782726451 1.1628028545039706 0.8939766182168158 0.48913508316169474 0.1120923331233985 0.36503340332822265 2.2497155344930486 0.05013911049849873 0.12661961585267434 1.927367491884931e-07 6.715035470356828 -0.26882623628715474 LGVQVVITDPEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGVQVVITDPEK 12 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 18721000.0 18721000.0 0.0 0.0 False True 28401125.68842852 0.0 0.0 1.0 0.0 0.0 24.759444776791092 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 LGVQVVITDPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGVQVVITDPEK 12 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 10544200.0 2119600.0 3879200.0 4545400.0 False True 2903273.400036223 3707804.1172010475 3471870.1354515012 1.0 1.2771115931261543 1.1958467760591145 21.469249005671823 -10.117194289341066 4.358774927879892 0.999970035067252 1.2364791845581935 0.91863742236763 0.033176222764511154 23132832.58896629 0.5958334565084135 7791.919642033776 0.011357103469263325 7.634941445139498e-11 10.117194289341066 0.23650914949094148 LGVQVVITDPEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGVQVVITDPEK 12 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 13779500.0 6060000.0 4863700.0 2855800.0 False True 5039158.503519133 4837498.282731142 3452934.5762726977 1.0 0.9599813697768864 0.6852204735892542 22.26475140539858 -6.933053958695909 0.721282066519853 1.0037418204529955 0.6241602293638515 0.99710517059548 0.007527831275030615 0.09108285568179975 0.0701367904920573 0.006987324772668174 0.02445706534178671 1.1666646564019892e-07 6.933053958695909 -0.379581591089144 LGVQVVITDPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGVQVVITDPEK 12 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 83444000.0 18721000.0 53200000.0 11523000.0 False True 24234703.546080098 50239373.233441584 9425932.235964466 1.0 2.0730343632186776 0.3889435749870803 24.53057109888354 -6.734602558358322 1.706624089604416 1.6424350374664505 0.3891165732972368 0.5803391461559977 0.4509399912531531 0.327704051119217 1.8718910111324039 0.20922522999043563 0.5164601794326412 1.8424573424944298e-07 6.734602558358322 -1.2533184641692137 LGVQVVITDPEK(ub)LDQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGVQVVITDPEKLDQIR 17 1 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 1 33221600.0 7446600.0 10522000.0 15253000.0 True False 11297036.619382067 8644266.891238762 12238237.864372607 1.0 0.7651800363652882 1.083313994342175 23.42944104612597 -6.7089865761411 1.7991892462449215 0.8554869533538891 1.0825329890685091 0.46015818133401587 0.09896757632970023 0.3770949227675385 2.3789711403934373 0.04378809856175195 0.11136378545821288 1.9543998645156574e-07 6.7089865761411 0.22704603571462 LGVQVVITDPEK(ub)LDQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGVQVVITDPEKLDQIR 17 1 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 1 5073300.0 1279800.0 2370700.0 1422800.0 True False 1064210.4047530997 2357928.5685528954 1720300.9017160833 1.0 2.2156601345200553 1.6165044938789137 20.021351983212632 -10.034685922632107 5.481787055788773 0.9999953195428148 1.9160823142002308 0.7571011424532843 0.2446042660161518 1.3991970348453061e-05 2.4641506287511248e-06 0.23683827182359563 0.07894568739060653 9.232388627731974e-11 10.034685922632107 0.9160869946574159 LGVQVVITDPEK(ub)LDQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGVQVVITDPEKLDQIR 17 1 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 1 29265500.0 7446600.0 6911900.0 14907000.0 True False 9639770.49443085 6527246.688951595 12194078.958736649 1.0 0.6771163994747135 1.2649760661606508 23.20056736821842 -6.757593802448081 1.6215923286449745 0.8118879563675716 1.2668662684481864 0.6810200110413862 0.1357628599752341 0.28699063182459716 1.486804933842271 0.06607586922706032 0.1591662109028339 1.7474557919662091e-07 6.757593802448081 0.4549783120806148 LGVQVVITDPEKLDQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGVQVVITDPEKLDQIR 17 1 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 7520400.0 4238700.0 2102100.0 1179600.0 False True 5556976.747629192 1788474.8739216242 1057546.3075221898 1.0 0.3218431451390637 0.1903096513717423 22.405868772875085 -13.999999999999998 0.2306022184749844 5.292969324032768 0.12672228936080593 0.9995106222883319 0.007848318518278597 13.31009496380279 0.15204486113813 26.171364640883443 0.06802273725877717 1.0000000000000041e-14 13.999999999999998 -5.1662470346719624 LGVQVVITDPEKLDQIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGVQVVITDPEKLDQIR 17 1 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 48228000.0 19111000.0 13380000.0 15737000.0 False True 18504331.76583249 18722703.775778245 11615007.600119673 1.0 1.0118011292009457 0.6276912750541103 24.141359701739614 -6.899812980289495 0.9624650214274745 1.0160519296866024 0.5875274765719873 0.9864725906643551 0.020743963425576464 0.11154253937681818 0.17820403496502776 0.016170775858677634 0.042033545322295716 1.2594676580754496e-07 6.899812980289495 -0.42852445311461507 LGVQVVITDPEKLDQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGVQVVITDPEKLDQIR 17 1 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 554885000.0 129218000.0 235546000.0 190121000.0 False True 196033153.1011887 193510975.97070205 152543501.01700553 1.0 0.9871339256111198 0.7781515453065503 27.546522422469796 -6.919483945667278 0.8285545623970317 1.0046973951141789 0.7448490828992922 0.9940361698666846 0.00785259567835547 0.09847630038330585 0.1071977816939028 0.006747388123350989 0.020112712763129214 1.203693885279321e-07 6.919483945667278 -0.2598483122148867 LGVQVVITDPEKLDQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGVQVVITDPEKLDQIR 17 1 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 9858000.0 4238700.0 1725600.0 3893700.0 False True 5805861.93656046 1649357.2862038906 2974088.2532686875 1.0 0.28408482740824725 0.5122561104218425 22.469078834397976 -10.130048403291623 5.15376259497232 1.0000196196085316 0.39817046891511604 0.9026864797350637 0.09315053622587172 2.115807695689011e-05 3.571293370871484e-06 0.09019557593238413 0.030064206290713373 7.412276248786576e-11 10.130048403291623 -0.6018491506934156 LGVQVVITDPEKLDQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGVQVVITDPEKLDQIR 17 1 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 37331900.0 19111000.0 9004800.0 9216100.0 False True 15891643.2608505 8956289.355087142 11143143.899568163 1.0 0.563584848217126 0.7011951952772313 23.92176497717389 -10.855098476520133 10.82684555570289 1.0099211239531065 0.6323900217471798 0.9048982290644403 0.05617918893742688 0.013020628104934031 0.00017426174501472988 0.05264445062306711 0.018131755263174513 1.3960517696329502e-11 10.855098476520133 -0.37753110220592667 LGVQVVITDPEKLDQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGVQVVITDPEKLDQIR 17 1 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 420870000.0 129218000.0 167049000.0 124603000.0 False True 167275248.26758054 157752576.3021275 101926532.53474618 1.0 0.9430718407889005 0.6093342176464758 27.317648744562245 -6.936327921084774 0.6928840256935053 1.0040882348769964 0.5282923409442671 0.9976422577899606 0.008367171026111925 0.08948260128331305 0.06254232479414208 0.007933806776506909 0.029218927954542187 1.1579027327792824e-07 6.936327921084774 -0.47579589393272925 LGVSFSFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGVSFSFAK 9 0 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 0 6099500.0 1322000.0 2557600.0 2219900.0 False True 1733154.8022662099 2176016.049446715 1990206.0427844264 1.0 1.2555231919280585 1.1483140687618358 20.72496908850065 -10.175513047433029 5.01517748875847 0.9999852011861239 1.201918630345239 0.8254689446226948 0.04376794125575296 7.242739045981102e-06 1.19069557210969e-06 0.04238123149881765 0.014126042298297994 6.675548454297839e-11 10.175513047433029 0.20193342915911505 LGVSFSFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGVSFSFAK 9 0 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 0 44489000.0 14332000.0 10027000.0 20130000.0 False True 21742691.809548497 8237603.508691414 16151296.676707577 1.0 0.37886769406692306 0.742837953008863 24.37402722554662 -10.34446405883828 6.056342632997468 1.000047039189148 0.5608528235379813 0.6599804228287923 0.14859023599273766 9.438611123343692e-05 1.0216438121238995e-05 0.14388722578105476 0.04795729245074174 4.5241390146438373e-11 10.34446405883828 -0.4391942156511668 LGVSFSFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGVSFSFAK 9 0 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 0 8045100.0 1322000.0 2517400.0 4205700.0 False True 1810779.1257066836 2406172.944071436 3212400.279110393 1.0 1.328805324687179 1.7740431361868643 20.78817915002354 -6.966901788776918 0.32375539794051694 0.9416504178914027 2.175638779658478 0.9999471509000614 0.002305890037481522 0.07732140207473545 0.012615217970279128 0.0066492801999969466 0.039036454759855836 1.0791907425063007e-07 6.966901788776918 1.2339883617670753 LGVSFSFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGVSFSFAK 9 0 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 0 7732500.0 3677600.0 1518700.0 2536200.0 False True 3058087.345303952 1510518.461661653 3066507.6939361366 1.0 0.49394222306345476 1.0027534689763242 21.54419818296771 -10.940899780512163 10.748565548219124 1.0582851701922604 0.7483478460198898 0.24594143993923812 0.20772132131271717 0.11620663999115513 0.0006389531142706712 0.08055752669988359 0.0670417681746961 1.1457773149806988e-11 10.940899780512163 -0.30993732417237063 LGVSFSFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGVSFSFAK 9 0 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 0 41355000.0 14332000.0 15172000.0 11851000.0 False True 18553056.525955867 14327664.862740118 9694239.601528678 1.0 0.7722536091395833 0.5225144217054674 24.14515354763907 -6.9699415411928065 0.25958085583050716 1.0704742522694362 0.21688846611134244 0.9999819216607516 0.0008290999222670907 0.07632171385082537 0.00909810626588038 0.005227514198582591 0.023578124275992457 1.0716635482780381e-07 6.9699415411928065 -0.8535857861580938 LGVTVLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGVTVLSR 8 0 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 0 165758000.0 48342000.0 46528000.0 70888000.0 False True 63376830.144593894 39586203.76472349 63553189.76571137 1.0 0.6246163412466004 1.0027827144512451 25.91745216790395 -10.983256982980574 10.499710447932346 1.1242845445198346 0.8136995278492378 0.24448147099657036 0.1543857753717154 0.07532824634583359 0.00012011965630988566 0.02506960812788222 0.049827794742164436 1.0393050009037538e-11 10.983256982980574 -0.3105850166705968 LGVTVLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGVTVLSR 8 0 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 0 109777600.0 43983000.0 14127600.0 51667000.0 False True 42586783.74007703 19768824.35446071 38133862.72322446 1.0 0.4642009238151721 0.8954388985082695 25.34390244229298 -9.97507678089093 7.289176755187424 1.000000004492494 0.6798199111617232 0.42363452151734693 0.17605216595155623 3.093906507217601e-08 4.355907887822873e-09 0.1704617830487208 0.05682059223284339 1.059066471460828e-10 9.97507678089093 -0.3201800933307707 LGVTVLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGVTVLSR 8 0 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 0 90603000.0 42022000.0 27048000.0 21533000.0 False True 63750446.219707415 22221073.073011402 17276993.111750834 1.0 0.3485634123474122 0.27100975971537483 25.92593210432744 -13.999999999999998 0.3002611801584675 6.951127599410451 0.2519792195848644 0.9996504137152669 0.006112242930233168 16.60546800903388 0.17403158993134946 61.40390773239029 0.027995920448348484 1.0000000000000041e-14 13.999999999999998 -6.699148379825586 LGVTVLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGVTVLSR 8 0 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 0 134585000.0 48342000.0 55323000.0 30920000.0 False True 66215343.793428525 52878646.93130378 23617332.81738908 1.0 0.798586005930421 0.35667462349916784 25.98066222942684 -6.958194465008096 0.4601785263339581 1.012857994202016 0.12458314390549748 0.9996972470439189 0.004675047177791741 0.08035257760125034 0.02356337324633877 0.006003476748368944 0.036505585460955135 1.1010461812425436e-07 6.958194465008096 -0.8882748502965184 down LGVTVLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGVTVLSR 8 0 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 0 72894500.0 43983000.0 19078900.0 9832600.0 False True 36573813.277274296 18976118.178834844 11888551.199194228 1.0 0.5188443992692977 0.3250563759667183 25.124307717727255 -13.99999999999421 0.12531102154693707 3.287230495958519 0.03678697727227587 0.9996673310473393 0.005175326966185198 11.94652296516231 0.1095928029778711 6.761423472975437 0.2560061789602484 1.00000000001333e-14 13.99999999999421 -3.250443518686243 LGVTVLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGVTVLSR 8 0 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 0 89716000.0 42022000.0 27950000.0 19744000.0 False True 54398307.377457246 26394557.929975405 16150794.5905478 1.0 0.48520917658025065 0.29689884426883323 25.69705842641989 -13.999999999999998 0.1398306983807033 3.45870140984554 0.0633789260717779 0.9996036094942004 0.0059166379291562335 11.933836952311815 0.11714636122999465 8.00685356801401 0.20874025759798334 1.0000000000000041e-14 13.999999999999998 -3.395322483773762 LGVYPTK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGVYPTKK 8 1 Q96MG7 Q96MG7 NDNL2 Melanoma-associated antigen G1 1 1569250.0 502280.0 711410.0 355560.0 True False 417668.07477683044 707577.4931261715 429905.95207630796 1.0 1.694114383782496 1.0293004853339975 18.67199734711784 -10.253789866444349 4.182304276063256 0.9997791636654981 1.361707434333736 0.28299351827226427 0.2714091392954852 191800911.93414035 237.93337200208987 505706.012883244 0.09291056715750975 5.574554087076358e-11 10.253789866444349 0.36192827066823796 LGWSIGPNHLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGWSIGPNHLIK 12 0 Q6YP21-3;Q6YP21 Q6YP21-3 CCBL2 Kynurenine--oxoglutarate transaminase 3 0 6108700.0 1769700.0 1452400.0 2886600.0 False True 2320093.8377991808 1235707.5814108585 2587922.3222224084 1.0 0.5326110355014947 1.1154386430668197 21.145751726655355 -6.693165631502825 1.8549543759365066 0.7078572079835169 1.113517688720038 0.3854037042095604 0.19754639999435866 0.40988602717741895 2.736777560066083 0.0851148816206371 0.22078210330950185 2.0269095480553023e-07 6.693165631502825 0.40566048073652106 LGWSIGPNHLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGWSIGPNHLIK 12 0 Q6YP21-3;Q6YP21 Q6YP21-3 CCBL2 Kynurenine--oxoglutarate transaminase 3 0 6207930.0 1968600.0 711330.0 3528000.0 False True 1906107.8705571592 995367.7785369451 2603910.9622686813 1.0 0.5221990811286021 1.366087933684232 20.862198335956204 -6.753110514740517 1.638364262078779 0.7200990060357446 1.368167065604399 0.6622159853803724 0.20081396941314075 0.2946598418212565 1.5570775051376942 0.09678780802248284 0.2342095578512162 1.7655884749336605e-07 6.753110514740517 0.6480680595686543 LGWSIGPNHLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGWSIGPNHLIK 12 0 Q6YP21-3;Q6YP21 Q6YP21-3 CCBL2 Kynurenine--oxoglutarate transaminase 3 0 6212100.0 1769700.0 2495600.0 1946800.0 False True 2424005.9143442693 2385336.140154394 1487005.935604563 1.0 0.9840471617824678 0.6134497968033303 21.208961788178247 -6.915931059294078 0.8543520300612424 1.0094363090621352 0.558942306845861 0.9929741381225856 0.014968664463435562 0.10062559646500395 0.11845483236100152 0.012626471645148152 0.036468840302217524 1.2135814813347527e-07 6.915931059294078 -0.4504940022162742 LGWVRPDLGELSK(ub)VTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGWVRPDLGELSKVTK 16 2 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 42025300.0 1987400.0 6219900.0 33818000.0 True False 3015031.098401948 5109910.248699485 27133857.477044076 1.0 1.694811788643866 8.999528227561497 21.52374145213905 -6.925392697262271 0.7836927137482995 0.8679314351722794 10.337134067186415 0.9955525660349205 0.24130648269994198 0.09510157447782473 0.0899258372719904 0.21408925380121036 0.6784623508417433 1.1874280470255295e-07 6.925392697262271 9.469202632014136 up LGWVRPDLGELSK(ub)VTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGWVRPDLGELSKVTK 16 2 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 38582600.0 1987400.0 5208200.0 31387000.0 True False 2572728.477510796 4918359.0916242525 25674888.05781625 1.0 1.9117287870125088 9.979633794335573 21.2948677742315 -6.928269765145769 0.760864175434336 0.8691139978348377 11.565222998611446 0.9961870764641277 0.24917808122804452 0.09354620288759265 0.08215585606591629 0.2247194298004178 0.737073563834852 1.1795876986448578e-07 6.928269765145769 10.696109000776609 LGYAGNTEPQFIIPSCIAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGYAGNTEPQFIIPSCIAIK 20 0 P61158 P61158 ACTR3 Actin-related protein 3 0 11934000.0 3086000.0 5860700.0 2987300.0 False True 4045775.884866514 4986306.4048296735 2678202.852205016 1.0 1.2324722245444377 0.6619750891845015 21.947984973563695 -6.7960819090992555 1.4719697094491828 1.1289084825472058 0.6548506048656362 0.8204299761774974 0.09925640095446574 0.2263972769837805 0.9688073499858975 0.05305968496778991 0.12369722109685087 1.5992563761452956e-07 6.7960819090992555 -0.4740578776815696 LGYAGNTEPQFIIPSCIAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGYAGNTEPQFIIPSCIAIK 20 0 P61158 P61158 ACTR3 Actin-related protein 3 0 8467900.0 6274700.0 2193200.0 0.0 False True 6075513.083097127 3068956.1973869074 0.0 1.0 0.5051353120981906 0.0 22.534574820212576 -7.912884099821783 0.5961123316612451 1.0097705885093098 2.6828353011529345e-18 0.988876418400716 0.04305804711443189 0.11283376909385785 0.1608741319839148 0.044625079379798586 0.07714875005586098 1.2221257653797569e-08 7.912884099821783 -1.0097705885093098 down LGYAGNTEPQFIIPSCIAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGYAGNTEPQFIIPSCIAIK 20 0 P61158 P61158 ACTR3 Actin-related protein 3 0 19390900.0 3086000.0 4900900.0 11404000.0 False True 4226977.596014246 4684362.032890954 8710610.072752422 1.0 1.1082060234499445 2.0607182969140734 22.011195035086587 -6.928361061380646 0.7601199400728169 0.9846011055012657 2.248348769902627 0.9962063948393481 0.02935331054712868 0.0934973407842548 0.08191334890419691 0.02648629910237709 0.08697522637732646 1.1793397549073272e-07 6.928361061380646 1.2637476644013614 up LGYAGNTEPQFIIPSCIAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGYAGNTEPQFIIPSCIAIK 20 0 P61158 P61158 ACTR3 Actin-related protein 3 0 11126300.0 6274700.0 1378500.0 3473100.0 False True 5217691.0663418295 1371073.7468891724 4199309.152199982 1.0 0.2627740373004576 0.8048213469917366 22.314980095646852 -10.066520005661518 6.8699343732674505 1.000000180147451 0.5337976921477416 0.4965537685452748 0.221289887532002 6.10546898871197e-07 8.272467488615817e-08 0.21426309528409573 0.0714210040912962 8.579855909308406e-11 10.066520005661518 -0.4662024879997093 LGYANAK(ub)IYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGYANAKIYK 10 1 P41091;H7BZU1 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 3905390.0 666240.0 1242900.0 1996250.0 True False 873447.0918773371 1057464.1647862538 1789697.1993821403 1.0 1.2106791294174453 2.0490047033478214 19.73636079051765 -6.944995654703392 0.6113333536216116 0.990744305387082 2.3126961161131536 0.9987476213563036 0.016034259723272937 0.08555987417912445 0.0447757422236547 0.016277971571409696 0.07072287248795864 1.1350221719835869e-07 6.944995654703392 1.3219518107260715 up LGYANAK(ub)IYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGYANAKIYK 10 1 P41091;H7BZU1 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 18572500.0 1949100.0 4692500.0 11930900.0 True False 2523148.372504928 4431358.249960981 9759598.621371897 1.0 1.756281278679471 3.868024063794066 21.266793615108543 -6.953051688644303 0.5242708464188013 0.9652641323965321 4.75397151060192 0.9994195265805185 0.02924100011485714 0.08228297297809739 0.03106622222157633 0.032905559504783015 0.17450937464173838 1.1141619209317886e-07 6.953051688644303 3.7887073782053875 LGYAVYETPTAHNGAK(ub)NPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGYAVYETPTAHNGAKNPR 19 1 E7EN89;Q9H0E2;E9PP67;E9PQ25;Q9H0E2-2 E7EN89 TOLLIP Toll-interacting protein 1 10826800.0 1933800.0 2766600.0 6126400.0 True False 2535230.526945839 2353834.0641223365 5492498.896578463 1.0 0.9284497165462784 2.166469217769797 21.2736855058863 -6.893192325375255 1.003289976796392 0.9384807438498712 2.2798633121182794 0.982864705998062 0.07428623399238289 0.11659187237255342 0.2070156890245173 0.05616607917510047 0.1417342833039351 1.278814861282984e-07 6.893192325375255 1.3413825682684082 up LGYAVYETPTAHNGAK(ub)NPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGYAVYETPTAHNGAKNPR 19 1 E7EN89;Q9H0E2;E9PP67;E9PQ25;Q9H0E2-2 E7EN89 TOLLIP Toll-interacting protein 1 17610600.0 2332000.0 2794600.0 12484000.0 True False 2257971.936472261 3910498.3536464726 9214065.888027828 1.0 1.731863133673855 4.0806821994534666 21.106596124804486 -6.949924856409618 0.5596672050681785 0.969226967006881 4.955508229829496 0.9991953788181928 0.03727729353634102 0.08351592009036718 0.03608723651692429 0.039975206974045635 0.1952364545958855 1.1222126077925772e-07 6.949924856409618 3.9862812628226147 LGYAVYETPTAHNGAK(ub)NPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGYAVYETPTAHNGAKNPR 19 1 E7EN89;Q9H0E2;E9PP67;E9PQ25;Q9H0E2-2 E7EN89 TOLLIP Toll-interacting protein 1 41965000.0 3704000.0 17595000.0 20666000.0 True False 5619238.798672043 14455034.779637534 16581356.041770441 1.0 2.572418666929335 2.9508188984047097 22.42194328059612 -10.086270060603928 0.3364684734123304 2.758825101496443e-15 3.0406780223438776 0.9988862333685334 0.02818967546420023 1.4787915487053382 0.15243522466737955 1.5270804553979853 0.1171858424979615 8.198415775339769e-11 10.086270060603928 3.040678022343875 LGYAVYETPTAHNGAK(ub)NPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGYAVYETPTAHNGAKNPR 19 1 E7EN89;Q9H0E2;E9PP67;E9PQ25;Q9H0E2-2 E7EN89 TOLLIP Toll-interacting protein 1 13944900.0 2332000.0 3325100.0 8287800.0 True False 1939161.3251166018 3307187.0263193278 10020740.661542408 1.0 1.705472867823654 5.167564210233958 20.887001400238763 -6.940222722818087 0.6574875608405079 0.961282931599036 6.10733113453941 0.9981929362307633 0.07742029425315972 0.08766515302253211 0.05414790993640963 0.07549065606561157 0.29768402026273266 1.1475649553716227e-07 6.940222722818087 5.146048202940374 LGYAVYETPTAHNGAK(ub)NPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGYAVYETPTAHNGAKNPR 19 1 E7EN89;Q9H0E2;E9PP67;E9PQ25;Q9H0E2-2 E7EN89 TOLLIP Toll-interacting protein 1 29324000.0 3704000.0 12880000.0 12740000.0 True False 4794901.016755555 12163216.67757004 10421450.723438963 1.0 2.536698178975177 2.173444391661412 22.19306960268857 -10.048086738603736 5.775905399617408 0.9999956967042382 2.355071285318526 0.9488601456533861 0.1482977376761872 8.218038947519209e-06 1.3543445043809463e-06 0.14358912233594562 0.0478628890248897 8.951859584547837e-11 10.048086738603736 1.3550755886142878 LGYFLALTGFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LGYFLALTGFR 11 0 Q6NVY1;Q6NVY1-2;B8ZZZ0;H7C400 Q6NVY1 HIBCH 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial 0 46075000.0 21606000.0 13949000.0 10520000.0 False True 20920129.35652645 19518908.44307404 7764496.406764889 1.0 0.9330204469784853 0.3711495409249274 24.318388436515427 -6.929224204714475 0.7531360008447996 1.0087949242609902 0.2580477665050727 0.9963834970400262 0.01695781340496011 0.09304275252693618 0.07966922888792036 0.015378658427024 0.05105827724833403 1.1769981908242245e-07 6.929224204714475 -0.7507471577559175 down LGYFLALTGFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LGYFLALTGFR 11 0 Q6NVY1;Q6NVY1-2;B8ZZZ0;H7C400 Q6NVY1 HIBCH 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial 0 307548000.0 74523000.0 80755000.0 152270000.0 False True 113056839.36107881 66343639.308305085 122173767.75768821 1.0 0.5868166816199241 1.0806402199825516 26.752473029506344 -6.6846904097534665 1.8849064868511718 0.7396921925114173 1.078851403055337 0.34590000775352725 0.17493861985045578 0.4281625873859076 2.94489967561983 0.07435806518001385 0.194966465630873 2.0668530032465193e-07 6.6846904097534665 0.33915921054391984 LGYFLALTGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGYFLALTGFR 11 0 Q6NVY1;Q6NVY1-2;B8ZZZ0;H7C400 Q6NVY1 HIBCH 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial 0 53866000.0 21606000.0 15598000.0 16662000.0 False True 17966346.30809147 15513970.478039423 20145947.16361638 1.0 0.8635016943346141 1.121315754363662 24.098793711949703 -6.762854383651566 1.6015830984925616 0.9209951792501243 1.122397105919321 0.702536963678011 0.057437873175929244 0.27816308344185264 1.4068361673804202 0.02828698666014101 0.06779176056715672 1.726416652159651e-07 6.762854383651566 0.20140192666919665 LGYFLALTGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LGYFLALTGFR 11 0 Q6NVY1;Q6NVY1-2;B8ZZZ0;H7C400 Q6NVY1 HIBCH 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial 0 243321000.0 74523000.0 96047000.0 72751000.0 False True 96471492.56794643 90701900.01790142 59511064.48829737 1.0 0.9401938085908498 0.6168772028315284 26.523599351598794 -6.938079775351752 0.6771950761936696 1.0037779634373878 0.5344040107783972 0.9979013654342673 0.00770950337434426 0.08865381200965579 0.058682195447376885 0.00739960337571823 0.02807081243768862 1.1532413999863039e-07 6.938079775351752 -0.4693739526589906 LGYLLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LGYLLFR 7 0 P25098;E9PRV7 P25098 ADRBK1 Beta-adrenergic receptor kinase 1 0 5874500.0 1343500.0 2146800.0 2384200.0 False True 1761341.5104725068 1826505.8081608561 2137505.8548613135 1.0 1.0369969692424204 1.213566955727907 20.748243233006125 -6.9408488975408105 0.6516173934740885 0.9980434206865755 1.2623955228357417 0.9982729984417452 0.0038726424616930813 0.08738144363313761 0.05286182530660775 0.00379443387518368 0.015141079858353062 1.1459115648322934e-07 6.9408488975408105 0.26435210214916627 LGYLLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGYLLFR 7 0 P25098;E9PRV7 P25098 ADRBK1 Beta-adrenergic receptor kinase 1 0 5305100.0 1343500.0 1384500.0 2577100.0 False True 1840228.2567223376 1323328.21207075 1968442.057040535 1.0 0.7191109077021526 1.0696727701304627 20.811453294529016 -6.693357363163212 1.8543978629154991 0.8244562474591621 1.068514806831601 0.38618274088789417 0.1187168654719242 0.4095150677794861 2.7328357175075757 0.05116423899579156 0.13267846707566494 2.0260149086398065e-07 6.693357363163212 0.24405855937243892 LGYLLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LGYLLFR 7 0 P25098;E9PRV7 P25098 ADRBK1 Beta-adrenergic receptor kinase 1 0 5622200.0 1906300.0 1612000.0 2103900.0 False True 1585172.9134089954 1603315.8360430505 2543815.762665497 1.0 1.011445390266629 1.6047560118819413 20.59620878994837 -6.911075813950397 0.8883710941422946 0.9822480300288291 1.6832236083837817 0.9913210598329751 0.026311008952529007 0.10371203269071155 0.134939409995125 0.02165622055921244 0.06023652873185344 1.2272249781597062e-07 6.911075813950397 0.7009755783549526 LGYTHLYSSTQVSVRPLQHTQYER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LGYTHLYSSTQVSVRPLQHTQYER 24 1 A0A0C4DGS1;P39656;P39656-3;P39656-2 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 0 16200000.0 6224800.0 4085000.0 5890200.0 False True 8526276.778894827 3904511.192711452 4499056.072476885 1.0 0.45793859312382695 0.5276694844827746 23.023484457966134 -10.48153097825606 6.143907746577177 1.0003309405219691 0.4928040388036579 0.9860219457189559 0.028467517189811855 0.00012912778763305007 1.089677630979314e-05 0.02758093182436832 0.009187851665334534 3.2996587058253707e-11 10.48153097825606 -0.5075269017183113 LHAEFAAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHAEFAAER 9 0 Q9H773 Q9H773 DCTPP1 dCTP pyrophosphatase 1 0 23489600.0 6357200.0 7700700.0 9431700.0 False True 8334350.763212384 6551785.577093501 8455798.15925488 1.0 0.786118290822714 1.0145719084176974 22.99063838855087 -11.121450026167308 11.526071114089511 3.502305358583046 0.9003450996148947 0.2023682616306436 0.09326579883343707 0.03727074420200377 0.0003927220285405224 0.0005612180386003306 0.030101407137719423 7.56049053143895e-12 11.121450026167308 -2.6019602589681514 LHAEFAAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHAEFAAER 9 0 Q9H773 Q9H773 DCTPP1 dCTP pyrophosphatase 1 0 19768100.0 6357200.0 7408200.0 6002700.0 False True 8707628.636870312 7080881.228358633 4584985.889487105 1.0 0.8131813520820563 0.5265481660613213 23.05384845007376 -6.964878943106952 0.36012458039375195 1.0246640550458466 0.3052409886405114 0.9999106266121222 0.001840753720613611 0.07800207765654599 0.015004987693947243 0.0038446403920650895 0.024480261684012822 1.0842290940386987e-07 6.964878943106952 -0.7194230664053352 LHAEFAAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHAEFAAER 9 0 Q9H773 Q9H773 DCTPP1 dCTP pyrophosphatase 1 0 13522000.0 5723100.0 5688300.0 2110600.0 False True 4759011.226318543 5657655.998860853 2551916.7016881933 1.0 1.1888301434492476 0.536228342470689 22.182230427086918 -6.82931034601951 1.3310768732785787 1.1009452140410978 0.518923434553172 0.9044753116034628 0.0847446344854078 0.18166114428884703 0.6297336612094957 0.049993090020830286 0.11504636480895038 1.4814590589462496e-07 6.82931034601951 -0.5820217794879258 LHAEFAAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHAEFAAER 9 0 Q9H773 Q9H773 DCTPP1 dCTP pyrophosphatase 1 0 22746300.0 5968700.0 11728000.0 5049600.0 False True 7726599.81066653 11075326.490259448 4130624.613271384 1.0 1.4334023712435602 0.534597975110485 22.881402246672064 -6.775587476001747 1.5529639512240245 1.2468169771810678 0.5284300858149024 0.7514596408254509 0.1829699423714377 0.25751418429335765 1.2263143019898322 0.09282573895039735 0.21986037563601793 1.676534612563863e-07 6.775587476001747 -0.7183868913661654 LHATVMNTLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHATVMNTLFR 11 0 H0YE76;H0YCB3;A0A5F9ZH79;Q8N9N2-2;Q8N9N2;H0YER2;A0A5F9ZI10;A0A5K1VW55;A0A5F9ZI37;A0A5F9ZHP1 H0YE76 ASCC1 Activating signal cointegrator 1 complex subunit 1 0 5053500.0 2071300.0 1560400.0 1421800.0 False True 2715494.3584977305 1327594.4023915606 1274685.7748686434 1.0 0.4888960266984367 0.46941205047239604 21.37278343535712 LHATVMNTLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHATVMNTLFR 11 0 H0YE76;H0YCB3;A0A5F9ZH79;Q8N9N2-2;Q8N9N2;H0YER2;A0A5F9ZI10;A0A5K1VW55;A0A5F9ZI37;A0A5F9ZHP1 H0YE76 ASCC1 Activating signal cointegrator 1 complex subunit 1 0 5324300.0 2071300.0 1613800.0 1639200.0 False True 2837115.584777801 1542496.9798770484 1252054.7203837053 1.0 0.543684927097482 0.4413125524745812 21.435993496880013 -13.999999999999996 0.21000811957462565 3.639120278030026 0.38102002390182593 0.9994900159125883 0.005484495436659467 12.7468522421743 0.14525088301511122 13.880747059336704 0.06063676210782527 1.0000000000000082e-14 13.999999999999996 -3.2581002541282 LHCLHFSSWDSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHCLHFSSWDSSK 13 0 O75717;O75717-2 O75717 WDHD1 WD repeat and HMG-box DNA-binding protein 1 0 8840000.0 4032300.0 2975200.0 1832500.0 False True 5286384.34884875 2531311.7572387685 1642890.478581227 1.0 0.4788361175044014 0.3107777206814351 22.333849889880664 -13.999999999999998 0.15830684421023739 3.557688582196467 0.14244228815920845 0.9995409245313457 0.006286929737921218 11.998822570777815 0.12567590277544655 9.424668573442 0.15310319513147141 1.0000000000000041e-14 13.999999999999998 -3.4152462940372588 LHCWSLTQYSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHCWSLTQYSK 11 0 P46976-2;P46976;C9JQ42;G5E9W8;C9J8R8;C9J7C7;P46976-3 P46976-2;P46976-3 GYG1 Glycogenin-1 0 4867400.0 2017400.0 2850000.0 0.0 False True 2644830.936529389 2424791.1092129867 0.0 1.0 0.9168038212661169 0.0 21.334744074337948 -7.098470677408974 0.9919756950399812 1.001043612009811 6.929229554234066e-18 0.9894235194434786 0.04659462022624772 0.08466213682124969 0.15853584535889506 0.03836600391003146 0.0678164760097991 7.971303092271112e-08 7.098470677408974 -1.001043612009811 down LHDAFFK(ub)WQTKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHDAFFKWQTKPK 13 2 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 6621500.0 2241300.0 2221000.0 2159200.0 True False 2938366.004780074 1889635.4573901931 1935786.696508914 1.0 0.6430905660888305 0.6587969957996436 21.48658267944359 -10.060778379246775 7.488173815302451 1.0000000323474867 0.6509437809508076 0.9984837639690266 0.006412123078730295 3.4621117080104103e-09 4.324140571981325e-10 0.006208512029520893 0.0020695038248128793 8.694039735126509e-11 10.060778379246775 -0.34905625139667906 LHDFVSK(ub)TVIKPESCVPCGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHDFVSKTVIKPESCVPCGK 20 2 F8VRL2;Q9H0H5 F8VRL2 RACGAP1 Rac GTPase-activating protein 1 1 130577000.0 44353000.0 54222000.0 32002000.0 True False 58147212.51506295 46132288.95570064 28690740.024860267 1.0 0.7933706012777507 0.4934155703066243 25.79320669706075 -6.96579592219641 0.3441186565398959 1.0310206820089607 0.24573457294577827 0.9999286240126304 0.0017570848030801307 0.07769189715587715 0.013913353299737656 0.00418311343814923 0.02588575500686002 1.0819422435655811e-07 6.96579592219641 -0.7852861090631824 down LHDFVSK(ub)TVIKPESCVPCGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHDFVSKTVIKPESCVPCGK 20 2 F8VRL2;Q9H0H5 F8VRL2 RACGAP1 Rac GTPase-activating protein 1 1 33065200.0 18515000.0 11648000.0 2902200.0 True False 17927251.45959862 16299107.143517533 2142026.755866257 1.0 0.9091804831459903 0.11948439283587846 24.095650980662985 -6.974342694832009 0.7966750542420594 1.0097017008116471 1.1333532487317295e-24 0.9961402581476299 0.024565864215477278 0.08415326674840483 0.08568229667965742 0.02223684450194278 0.06374740346647781 1.0608581206566666e-07 6.974342694832009 -1.0097017008116471 down LHDFVSK(ub)TVIKPESCVPCGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHDFVSKTVIKPESCVPCGK 20 2 F8VRL2;Q9H0H5 F8VRL2 RACGAP1 Rac GTPase-activating protein 1 1 135277000.0 57345000.0 40093000.0 37839000.0 True False 86996557.48106058 32938090.901961185 30360105.06457716 1.0 0.3786137274355012 0.3489805337548747 26.374454977779052 -13.60677196529132 0.43748707955629046 9.999999997970377 0.3486164850343886 0.9998793551874817 0.00329682633494842 23.06618156132771 0.22275159485083307 197.2128532614634 0.00688946549300224 2.473022312318468e-14 13.60677196529132 -9.651383512935988 LHDFVSK(ub)TVIKPESCVPCGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHDFVSKTVIKPESCVPCGK 20 2 F8VRL2;Q9H0H5 F8VRL2 RACGAP1 Rac GTPase-activating protein 1 1 108364000.0 44353000.0 42001000.0 22010000.0 True False 60751502.69475684 40145256.94126651 16811691.310178943 1.0 0.6608109291217786 0.27672881434140845 25.85641675858364 -7.324439875753234 0.32970419588181693 1.06065547019715 3.8447591971206786e-14 0.9997639860549635 0.00453913084740905 0.10677214333043386 0.02531857310374189 0.013429841843093225 0.05178179168658959 4.7376189179691896e-08 7.324439875753234 -1.0606554701971116 down LHDFVSK(ub)TVIKPESCVPCGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHDFVSKTVIKPESCVPCGK 20 2 F8VRL2;Q9H0H5 F8VRL2 RACGAP1 Rac GTPase-activating protein 1 1 30139400.0 18515000.0 2736300.0 8888100.0 True False 15396042.85357373 2721559.0087869717 10746560.616068814 1.0 0.17677003335667146 0.698007969857938 23.87605625609726 -9.95830237118711 6.092512666516681 1.0000002533099184 0.4373890016535583 0.6083652277239074 0.2127944965018229 7.320713241314606e-07 1.254785342975944e-07 0.206037477382151 0.0686791284263066 1.1007726458130304e-10 9.95830237118711 -0.5626112516563601 LHDFVSK(ub)TVIKPESCVPCGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHDFVSKTVIKPESCVPCGK 20 2 F8VRL2;Q9H0H5 F8VRL2 RACGAP1 Rac GTPase-activating protein 1 1 130660000.0 57345000.0 33101000.0 40214000.0 True False 74234232.93894367 31258900.25188251 32895464.630484674 1.0 0.42108470734239817 0.4431306599145519 26.145581299871502 -10.151412827442003 5.968565010243831 1.000004891231338 0.4321076836285225 0.9988709931008555 0.009000222449262622 5.857989151101192e-07 8.328532326104159e-08 0.00871450293091081 0.0029048093048414606 7.056464687711728e-11 10.151412827442003 -0.5678972076028155 LHEILQK(ub)DR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHEILQKDR 9 1 A0A087WZV0;O43314-2;O43314 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 1 1238110.0 544520.0 0.0 693590.0 True False 713870.9931391813 0.0 621823.960185077 1.0 0.0 0.8710592896493301 19.44530385629006 -9.066863908269656 11.6165058490788 0.9999907899062352 0.43552964480899187 0.3589412719264071 0.3556084659318553 0.0 0.0 0.34431641656310497 0.1147721388543683 8.573064510836587e-10 9.066863908269656 -0.5644611450972434 LHEILQK(ub)DR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHEILQKDR 9 1 A0A087WZV0;O43314-2;O43314 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 1 2468980.0 865290.0 1078600.0 525090.0 True False 719526.9738465465 1072789.3677146619 634883.8912581512 1.0 1.4909647681164704 0.8823628777446679 19.456689246607677 -6.6920220851464975 1.8591365540195481 1.3072201333607167 0.884409955215395 0.3799134873598041 0.20755947259288668 0.41235744979710415 2.7648669954528264 0.08925892174014313 0.2318538282516617 2.0322536622570487e-07 6.6920220851464975 -0.42281017814532174 LHEILQK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHEILQKDR 9 1 A0A087WZV0;O43314-2;O43314 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 1 4211320.0 987620.0 1448200.0 1775500.0 True False 1278493.5589006783 1367606.3969298867 1452377.2181684382 1.0 1.0697014368268172 1.1360066760268037 20.286013461569393 -6.971731655687503 0.21280502013169478 0.9665038688239564 1.2410610951028458 0.9999929116949554 0.0001477302811938111 0.0757446568370079 0.006983212808224732 0.0019420215068271295 0.006826926735920275 1.0672553592751216e-07 6.971731655687503 0.27455722627888934 LHFFMPGFAPLTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHFFMPGFAPLTAR 14 0 A0A0B4J269;Q13509;Q13509-2 A0A0B4J269 TUBB3 Tubulin beta-3 chain 0 4006700.0 1290100.0 1326500.0 1390100.0 False True 1249146.4816650362 1856178.367606116 1025991.1078939044 1.0 1.485957327544119 0.821353718681832 20.252511234404945 -6.71070186146104 1.792878347987527 1.2985427278100141 0.8228939549425689 0.46837538081095653 0.20475719974384915 0.37365625424184795 2.3417825730508737 0.09087286777092352 0.23064839121859174 1.9466960091087624e-07 6.71070186146104 -0.4756487728674452 LHFFMPGFAPLTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHFFMPGFAPLTAR 14 0 A0A0B4J269;Q13509;Q13509-2 A0A0B4J269 TUBB3 Tubulin beta-3 chain 0 4970700.0 1290100.0 1715200.0 1965400.0 False True 1072775.3111204668 1705959.8771594565 2376356.0530171436 1.0 1.5902303674174383 2.215147970300644 20.03291650983922 -6.970402009250384 0.24839754619941154 0.7977297305461228 3.0259143992935655 0.9999853502616546 0.0018990020813604957 0.07617247709641212 0.00856216459598659 0.01409071046013114 0.06005051091407281 1.0705279010567069e-07 6.970402009250384 2.228184668747443 LHFFMPGFAPLTAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHFFMPGFAPLTAR 14 0 A0A0B4J269;Q13509;Q13509-2 A0A0B4J269 TUBB3 Tubulin beta-3 chain 0 7540100.0 1772100.0 2987400.0 2780600.0 False True 2294018.383313312 2821148.5638643447 2274559.3313653357 1.0 1.2297846365946223 0.9915174821224095 21.129445521884836 -6.654421364991729 1.9924545677079617 1.1485856109389003 0.9925139011249212 0.2121593050721775 0.0979694614624398 0.49788175708211135 3.79334497211867 0.03980576723048677 0.10856468282941455 2.2160453055687206e-07 6.654421364991729 -0.1560717098139791 LHFFMPGFAPLTSR ddPTM_RPMI8226_Bortezomib_1h_R1 2 LHFFMPGFAPLTSR 14 0 P04350;A6NNZ2;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q3ZCM7;A0A075B736;Q5SQY0;Q9BUF5;K7ESM5;Q9BVA1 P04350;P07437;P68371;Q13885;Q3ZCM7;Q9BUF5;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB8;TUBB6;TUBB2B Tubulin beta-4A chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-8 chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 2070176140.0 450314840.0 916949290.0 702912010.0 False True 590367116.0951138 780144030.1723384 630181418.0133102 1.0 1.3214557669344336 1.0674399044810314 29.137037123505774 -10.279009046243413 5.223350720471831 0.9999666724643136 1.1944478357077473 0.4386153466834274 0.10370154159740418 4.0255526936168005e-05 5.556365044757397e-06 0.1004257789167824 0.033469528631884245 5.2600630969917354e-11 10.279009046243413 0.19448116324343367 LHFFMPGFAPLTSR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LHFFMPGFAPLTSR 14 0 P04350;A6NNZ2;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q3ZCM7;A0A075B736;Q5SQY0;Q9BUF5;K7ESM5;Q9BVA1 P04350;P07437;P68371;Q13885;Q3ZCM7;Q9BUF5;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB8;TUBB6;TUBB2B Tubulin beta-4A chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-8 chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 3681587080.0 1240889310.0 1108527170.0 1332170600.0 False True 1201497958.0825164 1551167849.8738241 983235155.598651 1.0 1.2910282863479432 0.8183410957833059 30.16218705062988 -6.740131895500862 1.6861475126497396 1.1731361958727604 0.8180536154430562 0.6055275959918988 0.12227773854771862 0.3175956343620188 1.7729966060491262 0.057367579579459795 0.1407580814977048 1.8191482982524208e-07 6.740131895500862 -0.3550825804297042 LHFFMPGFAPLTSR ddPTM_RPMI8226_Bortezomib_8h_R1 2 LHFFMPGFAPLTSR 14 0 P04350;A6NNZ2;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q3ZCM7;A0A075B736;Q5SQY0;Q9BUF5;K7ESM5;Q9BVA1 P04350;P07437;P68371;Q13885;Q3ZCM7;Q9BUF5;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB8;TUBB6;TUBB2B Tubulin beta-4A chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-8 chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 3685845500.0 1312223900.0 990272400.0 1383349200.0 False True 1990739592.7172601 813550553.1864233 1109929624.2765057 1.0 0.40866749029488453 0.5575463653493259 30.890657369436383 -10.319343921689294 8.653125928386464 1.0000006661897556 0.48310692782241793 0.9414250722092999 0.06077954622715875 7.810855715551426e-07 6.146418032484087e-08 0.05884961754879438 0.019616514193985815 4.793536938082073e-11 10.319343921689294 -0.5168937383673377 LHFFMPGFAPLTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LHFFMPGFAPLTSR 14 0 P04350;A6NNZ2;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q3ZCM7;A0A075B736;Q5SQY0;Q9BUF5;K7ESM5;Q9BVA1 P04350;P07437;P68371;Q13885;Q3ZCM7;Q9BUF5;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB8;TUBB6;TUBB2B Tubulin beta-4A chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-8 chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 3438584210.0 450314840.0 1150893020.0 1837376350.0 False True 616808405.6489755 1100042760.8821268 1403425898.0837493 1.0 1.7834432066870358 2.275302809155354 29.200247185028665 -8.674297410030974 0.14615838599243994 1.761858735650074e-10 3.1917452595760136 0.9998885330780568 0.00554449134361875 0.24764131318382884 0.0406526916363734 0.4538970092901266 0.35157498648804275 2.1169109529342088e-09 8.674297410030974 3.191745259399828 LHFFMPGFAPLTSR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LHFFMPGFAPLTSR 14 0 P04350;A6NNZ2;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q3ZCM7;A0A075B736;Q5SQY0;Q9BUF5;K7ESM5;Q9BVA1 P04350;P07437;P68371;Q13885;Q3ZCM7;Q9BUF5;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB8;TUBB6;TUBB2B Tubulin beta-4A chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-8 chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 3636533600.0 1240889310.0 1054893030.0 1340751260.0 False True 1031854441.9822582 1049210111.8675184 1621096149.5325928 1.0 1.0168198819321055 1.5710511905326139 29.942592326064155 -6.913377843652984 0.8724215493469989 0.9846180143758179 1.6481014452613523 0.9921348436956132 0.02353013801702184 0.10222672701306211 0.1269669435265871 0.019592082235102268 0.055436163759690786 1.2207371357652266e-07 6.913377843652984 0.6634834308855344 LHFFMPGFAPLTSR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LHFFMPGFAPLTSR 14 0 P04350;A6NNZ2;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q3ZCM7;A0A075B736;Q5SQY0;Q9BUF5;K7ESM5;Q9BVA1 P04350;P07437;P68371;Q13885;Q3ZCM7;Q9BUF5;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB8;TUBB6;TUBB2B Tubulin beta-4A chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-8 chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 4650506100.0 1312223900.0 1957846200.0 1380436000.0 False True 1698699706.3501432 1848890337.8848715 1129210812.4694824 1.0 1.0884150571011935 0.6647501075370909 30.661783691528832 -6.852257636016287 1.2243067589426329 1.0472850207583542 0.6470770506649337 0.9435033579683172 0.04337451825267717 0.1549946517843069 0.4459632180891451 0.027706682470455254 0.06420796544967672 1.4052136635329341e-07 6.852257636016287 -0.40020797009342046 LHFIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHFIFR 6 0 P27824;P27824-2;P27824-3;D6RFL1;H0Y9H1;D6RGY2;O14967 P27824 CANX;CLGN Calnexin;Calmegin 0 215577000.0 65055000.0 61889000.0 88633000.0 False True 85287734.9935162 52655402.44143258 79462107.38777076 1.0 0.617385400672624 0.9316944270335198 26.34583495046458 -9.973259313343275 6.705093073325601 1.0000000294223803 0.7745399138530704 0.4069025564449693 0.12831612268920234 5.6431756350356895e-08 8.559412908795244e-09 0.12424156821836087 0.04141385051876488 1.0635078176194687e-10 9.973259313343275 -0.2254601155693099 LHFIFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHFIFR 6 0 P27824;P27824-2;P27824-3;D6RFL1;H0Y9H1;D6RGY2;O14967 P27824 CANX;CLGN Calnexin;Calmegin 0 79034000.0 36759000.0 14973000.0 27302000.0 False True 35592105.66585929 20951796.98316347 20150787.157556534 1.0 0.5886641599645756 0.5661588933999373 25.085053950917917 -13.999999999999998 0.41398204009990336 8.588430615606788 0.5652574885118599 0.9998566003275741 0.0023880620700893877 28.951291575956013 0.21381118324601273 198.33586185361528 0.0055467119958198035 1.0000000000000041e-14 13.999999999999998 -8.023173127094928 LHFIFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHFIFR 6 0 P27824;P27824-2;P27824-3;D6RFL1;H0Y9H1;D6RGY2;O14967 P27824 CANX;CLGN Calnexin;Calmegin 0 30568400.0 8370800.0 7115600.0 15082000.0 False True 12699115.58745246 5845765.585563453 12101036.089324562 1.0 0.4603285595210618 0.952903846412829 23.59822469018332 -10.490995807735418 9.053149290147292 1.0000072334449919 0.7066162029669457 0.321115686912142 0.20109301879831085 2.9359862831629303e-05 1.650881906988506e-06 0.19471227272210773 0.06490249273703604 3.228525286665103e-11 10.490995807735418 -0.29339103047804616 LHFIFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHFIFR 6 0 P27824;P27824-2;P27824-3;D6RFL1;H0Y9H1;D6RGY2;O14967 P27824 CANX;CLGN Calnexin;Calmegin 0 171619000.0 65055000.0 38625000.0 67939000.0 False True 89107591.54527114 36918419.784205616 51893207.44762597 1.0 0.41431284522429496 0.5823657283034253 26.409045011987473 -10.80848695836829 10.784852357553808 1.004314894809322 0.49833928676398226 0.9223685817565972 0.06860730222457839 0.007097716484196639 0.00012603815255886726 0.06623959800899264 0.0221429115786676 1.554221962527585e-11 10.80848695836829 -0.5059756080453397 LHFIFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHFIFR 6 0 P27824;P27824-2;P27824-3;D6RFL1;H0Y9H1;D6RGY2;O14967 P27824 CANX;CLGN Calnexin;Calmegin 0 68329000.0 36759000.0 18663000.0 12907000.0 False True 30566737.19981183 18562458.714684524 15605794.024774734 1.0 0.6072764192443411 0.5105482447394092 24.865459226352193 -13.999999999999998 0.19679381926129122 3.1570133289999673 0.4457061311190366 0.9994870828883415 0.004793315189182208 12.469381793069546 0.14067440724394742 10.339427557107346 0.06309730235883984 1.0000000000000041e-14 13.999999999999998 -2.711307197880931 LHFIFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHFIFR 6 0 P27824;P27824-2;P27824-3;D6RFL1;H0Y9H1;D6RGY2;O14967 P27824 CANX;CLGN Calnexin;Calmegin 0 38814800.0 8370800.0 17336000.0 13108000.0 False True 10836165.61313644 16371236.36043123 10722478.499437828 1.0 1.5107960643001568 0.9895085477873472 23.369351012275768 -10.745746453165419 3.667857504995798 0.9707827907527103 1.2501523060467516 0.23491170867214595 0.21281473746619223 157608661.93868047 665026.3053067819 38879452.84039509 0.07285214483941563 1.795781721861654e-11 10.745746453165419 0.2793695152940413 LHFLAPSEEDEMNDK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHFLAPSEEDEMNDKK 16 1 Q8N543;A0A0A0MTR2;Q8N543-2 Q8N543 OGFOD1 Prolyl 3-hydroxylase OGFOD1 1 29905500.0 4960800.0 5312700.0 19632000.0 True False 6421853.391987287 5017043.5747613665 16059177.44133076 1.0 0.7812454237932716 2.500707577872801 22.614558298687573 -6.874968543692561 1.1075252901959842 0.8716692797547639 2.6113701480284077 0.9693930040947916 0.13370219683986498 0.13217782822258706 0.30004227911340053 0.09338047303311463 0.2231902336889487 1.333618023718324e-07 6.874968543692561 1.7397008682736437 up LHFLMTGYTPLTTDQSVASVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHFLMTGYTPLTTDQSVASVR 21 0 P23258;Q9NRH3 P23258 TUBG1;TUBG2 Tubulin gamma-1 chain;Tubulin gamma-2 chain 0 13304100.0 5370400.0 2836800.0 5096900.0 False True 5199919.591608337 3969549.033716568 3761868.986277565 1.0 0.7633866185397656 0.7234475302942169 22.310057883792364 -13.999999998842343 0.2503124418778654 2.648130421115672 0.7074363113206726 0.9995432748237659 0.00260830562018104 14.010325538797865 0.1583147632135106 11.612543572918934 0.018399622197515373 1.0000000026656039e-14 13.999999998842343 -1.9406941097949995 LHFLMTGYTPLTTDQSVASVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHFLMTGYTPLTTDQSVASVR 21 0 P23258;Q9NRH3 P23258 TUBG1;TUBG2 Tubulin gamma-1 chain;Tubulin gamma-2 chain 0 4936900.0 1264300.0 1023800.0 2648800.0 False True 1731745.876422815 978565.1307461408 2023207.9937483903 1.0 0.5650743241655735 1.1683053624055018 20.72379580786275 -6.713247966969611 1.7835743317072466 0.7335085955224515 1.1670310612699304 0.480521642211986 0.1831852695267459 0.3685927817123551 2.2876071410046848 0.08167147447135388 0.2066749378481764 1.9353166502652051e-07 6.713247966969611 0.4335224657474789 LHFQEVVLTPGDNPQFLGK(ub)PGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHFQEVVLTPGDNPQFLGKPGR 22 1 Q15572-2;Q15572-6;Q15572 Q15572-2 TAF1C TATA box-binding protein-associated factor RNA polymerase I subunit C 1 30882500.0 6086900.0 5009600.0 19786000.0 True False 9234272.311996974 4115597.7398165534 15875288.427488115 1.0 0.4456872832816133 1.7191704869763555 23.138566846369773 -6.788428211613945 1.502827871241377 0.6895545514740932 1.7320902032666436 0.796104246502964 0.2354134782036695 0.23771494619510677 1.060679514446774 0.1233160377163272 0.2890197381595801 1.627690348777611e-07 6.788428211613945 1.0425356517925506 LHFQEVVLTPGDNPQFLGK(ub)PGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHFQEVVLTPGDNPQFLGKPGR 22 1 Q15572-2;Q15572-6;Q15572 Q15572-2 TAF1C TATA box-binding protein-associated factor RNA polymerase I subunit C 1 40240200.0 6086900.0 6599300.0 27554000.0 True False 7879612.04073686 6232043.153749068 22539454.727915037 1.0 0.7909073595920695 2.8604777254753353 22.909693168462223 -6.88201283068696 1.0684588853387111 0.8665929292037572 3.012958464001349 0.9752752107285101 0.14627298047684675 0.1258643223602784 0.26161135403212143 0.10525576189817124 0.25589944850136664 1.3121611322880304e-07 6.88201283068696 2.146365534797592 up LHGLDEEAEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHGLDEEAEQK 11 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 4993860.0 1344800.0 491760.0 3157300.0 False True 1302110.0601063024 688122.3324945213 2330308.4130302984 1.0 0.5284671039545951 1.7896401267647495 20.312419965952795 -6.80545286567418 1.4336392980965624 0.7416052145767906 1.8094669700281778 0.8476015688001046 0.2031169460725379 0.21306727515810525 0.8639205433001977 0.11143262707776491 0.25832864653921794 1.5651181735287005e-07 6.80545286567418 1.0678617554513872 LHGLDEEAEQK(ub)LFSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHGLDEEAEQKLFSEK 16 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 8514500.0 2540200.0 3032300.0 2942000.0 True False 3330226.799331793 2579892.6598128243 2637590.0616567372 1.0 0.7746897779846338 0.7920151450904086 21.667189002215075 -10.46345312051367 6.032588731330105 1.0001255992655806 0.7833524615375212 0.9952264570027376 0.00707305150259155 1.1955001664210926e-05 1.0633100535926395e-06 0.006852402093116007 0.0022828175563670175 3.439908411261902e-11 10.46345312051367 -0.2167731377280594 LHGLDEEAEQK(ub)LFSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHGLDEEAEQKLFSEK 16 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 14228100.0 4951800.0 4818400.0 4457900.0 True False 4794607.819478286 6742412.247624048 3290242.255866652 1.0 1.4062489574710841 0.6862380365084108 22.192981382475153 -6.753625679709828 1.6364159084720196 1.2378350413603454 0.6844016735374856 0.6644132547509398 0.17074849846706763 0.29377060827549223 1.548826451808584 0.08238919677242267 0.1992641232965993 1.7634953558336617e-07 6.753625679709828 -0.5534333678228598 LHGLDEEAEQK(ub)LFSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHGLDEEAEQKLFSEK 16 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 25548100.0 7833400.0 5766700.0 11948000.0 True False 11883840.498249862 4737587.329567246 9586472.563005572 1.0 0.3986579364023737 0.8066813556120495 23.50249781115787 -10.060096401015743 6.067877212367106 1.0000007869227727 0.6026696460072454 0.5583748453552224 0.16657486336162153 1.7733491474377071e-06 2.746797297931109e-07 0.16128573634705914 0.053761805974687174 8.707702822803622e-11 10.060096401015743 -0.39733114091552735 LHGLDEEAEQK(ub)LFSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHGLDEEAEQKLFSEK 16 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 10153100.0 2540200.0 3763000.0 3849900.0 True False 3479380.5863238443 3596738.217423058 2940632.91117937 1.0 1.0337294608013 0.8451598893026845 21.730399063737966 -6.860642554278452 1.1823687922543795 1.0183343756495613 0.8359107069560532 0.9544242153904063 0.017528251434376693 0.14614756752950117 0.38785223486188014 0.011558830934336661 0.02700366177597731 1.3783434466274814e-07 6.860642554278452 -0.18242366869350812 LHGLDEEAEQK(ub)LFSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHGLDEEAEQKLFSEK 16 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 12071800.0 4951800.0 4611900.0 2508100.0 True False 4117641.1019349946 4587054.7793095205 3032532.1138558574 1.0 1.1140006294268665 0.7364731502293353 21.97338665790943 -6.825735949649274 1.3470055048811653 1.0611148082661024 0.7271813878229324 0.8970433273068865 0.050730349443838925 0.1861337817120882 0.6620066414981078 0.029583680244828027 0.06809971120853862 1.4937023021642648e-07 6.825735949649274 -0.33393342044317 LHGLFAVYKPPGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHGLFAVYKPPGLK 14 1 O95900 O95900 TRUB2 Probable tRNA pseudouridine synthase 2 0 6780000.0 1662300.0 2138100.0 2979600.0 False True 2179291.3977360977 1819103.8142485241 2671299.574341404 1.0 0.8347226149464246 1.2257652084142656 21.055427684530347 -6.79189264978683 1.488871766515886 0.9078520020050133 1.2301367512833492 0.8073512693130964 0.07034877450521444 0.23255065637830566 1.0183603304293605 0.03718781726725166 0.08694316849043791 1.6147576481408273e-07 6.79189264978683 0.32228474927833595 LHGLFAVYKPPGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHGLFAVYKPPGLK 14 1 O95900 O95900 TRUB2 Probable tRNA pseudouridine synthase 2 0 5990100.0 1662300.0 1903700.0 2424100.0 False True 2276897.2319683973 1819588.2393059477 1851577.5059066275 1.0 0.7991525545195107 0.8132020540540263 21.11863774605324 -10.060084762558375 4.8991860468016775 1.0000048148749587 0.8061773042849194 0.9960747611388238 0.005735684173230299 3.0165461860675413e-07 5.7872997782781555e-08 0.005553690255286239 0.0018511841059240632 8.70793617963924e-11 10.060084762558375 -0.19382751059003933 LHGLNINYNCEICGNYTYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHGLNINYNCEICGNYTYR 19 0 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 0 43487000.0 12674000.0 17068000.0 13745000.0 False True 19227384.593512256 14022082.047107326 11028294.725352488 1.0 0.7292766199641466 0.5735722750911052 24.196659197529733 -12.488077897617012 0.0728659155109648 2.2832759380512977 1.619786779583398e-11 0.9999408483041061 0.001355041627787397 7.096695114208412 0.05972509042057997 1.8424219315086219 0.4504677315735657 3.2502899304151607e-13 12.488077897617012 -2.2832759380351 LHGLNINYNCEICGNYTYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHGLNINYNCEICGNYTYR 19 0 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 0 36527400.0 12674000.0 14046000.0 9807400.0 False True 16406742.841889806 13264327.75257369 8022553.832421935 1.0 0.8084680719628956 0.488979068528989 23.967785519622183 -6.963432528444799 0.38400813926892813 1.0209804398957585 0.2650965690725231 0.9998770931130594 0.002336906212685131 0.07849700261313931 0.016761088774152104 0.00414230193803459 0.026945901682238104 1.0878461311873815e-07 6.963432528444799 -0.7558838708232354 down LHGSVGGAQNLSALGALVSLSNAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHGSVGGAQNLSALGALVSLSNAR 24 0 C9JFV4;Q8IZL8;I3L445;I3L1P4;I3L4M7 C9JFV4 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 0 13605100.0 4208800.0 4333000.0 5063300.0 False True 4075193.9477806413 6063189.496296489 3737069.8342559575 1.0 1.4878284503731445 0.9170287063984214 21.958437291451418 -6.68037428215734 1.9001944539775986 1.3085467370522497 0.9191769609703544 0.32595873157536226 0.20673581482764103 0.43771594374309636 3.055923612366611 0.0872821319514452 0.23012105348183448 2.0874963166077397e-07 6.68037428215734 -0.38936977608189527 LHGSVGGAQNLSALGALVSLSNAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHGSVGGAQNLSALGALVSLSNAR 24 0 C9JFV4;Q8IZL8;I3L445;I3L1P4;I3L4M7 C9JFV4 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 0 22339900.0 6218600.0 8032200.0 8089100.0 False True 9434070.840556687 6598791.154134962 6490285.839421526 1.0 0.6994638121400389 0.6879623811515228 23.16944900344758 LHGSVGGAQNLSALGALVSLSNAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHGSVGGAQNLSALGALVSLSNAR 24 0 C9JFV4;Q8IZL8;I3L445;I3L1P4;I3L4M7 C9JFV4 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 0 8875200.0 1914300.0 1679400.0 5281500.0 False True 2622068.4420123356 1605198.5549668577 4034118.4759068713 1.0 0.6121878930570287 1.5385252388037751 21.322273913031474 -6.792981085233105 1.4843778049145757 0.7840911223480294 1.5492064883540844 0.8108543916723199 0.16519590649666077 0.23093052246512485 1.0051061411725581 0.08758338629763818 0.20462000230880015 1.6107157849301953e-07 6.792981085233105 0.765115366006055 LHGSVGGAQNLSALGALVSLSNAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHGSVGGAQNLSALGALVSLSNAR 24 0 C9JFV4;Q8IZL8;I3L445;I3L1P4;I3L4M7 C9JFV4 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 0 11702500.0 4208800.0 2708800.0 4784900.0 False True 3499803.681454012 2694207.156745299 5785400.467122075 1.0 0.7698166531518066 1.6530642840853575 21.738842566885694 -6.837481699541236 1.2940340884427521 0.8774801379548485 1.6806974742628793 0.9200391175493079 0.10578753544664164 0.17175958530363852 0.5597805956944674 0.06412828294821407 0.1476549037711199 1.4538456469933368e-07 6.837481699541236 0.8032173363080308 LHGSVGGAQNLSALGALVSLSNAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHGSVGGAQNLSALGALVSLSNAR 24 0 C9JFV4;Q8IZL8;I3L445;I3L1P4;I3L4M7 C9JFV4 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 0 19638900.0 6218600.0 9159100.0 4261200.0 False True 8050100.286931991 8649388.033504035 3485705.323604249 1.0 1.0744447553709224 0.43300147816328655 22.940575325540028 -6.877989156199757 1.090907081192587 1.0450243409709605 0.3892519171960285 0.9720289543532065 0.04790734643557896 0.12942837320894837 0.28315098147669254 0.03388670318508561 0.08154715285214088 1.3243746027903826e-07 6.877989156199757 -0.6557724237749321 down LHGVNINVEASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHGVNINVEASK 12 0 Q9BQ04;E9PLB0;E9PM61;U3KQD5;Q9BWF3;E9PB51;D6R9K7;J3QRR5;Q9BWF3-3;Q9BWF3-4;Q9BWF3-2 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 0 19069500.0 5502100.0 7593100.0 5974300.0 False True 7213306.382412195 6460239.077671979 5356136.7455322305 1.0 0.8956002608489806 0.7425355948545042 22.782229272354797 -6.965634388653119 0.34700126443129087 1.0153116675990532 0.6176829931605616 0.9999256192373902 0.0009118720749306627 0.0777464291112087 0.014105157452132684 0.0021176223198816216 0.0131829072154151 1.0823447411287243e-07 6.965634388653119 -0.3976286744384916 LHGVNINVEASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHGVNINVEASK 12 0 Q9BQ04;E9PLB0;E9PM61;U3KQD5;Q9BWF3;E9PB51;D6R9K7;J3QRR5;Q9BWF3-3;Q9BWF3-4;Q9BWF3-2 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 0 14812500.0 4732000.0 2560000.0 7520500.0 False True 4581785.250165845 3582221.350223641 5550655.4398360625 1.0 0.7818396442945414 1.2114612834888208 22.12747840994378 -6.768658170657998 1.5795424834583731 0.8746536613437547 1.2137583331612638 0.7254048145402207 0.09191250012032944 0.26861257106089237 1.322404548854872 0.045871308798314185 0.10932983549021026 1.7034987896806836e-07 6.768658170657998 0.33910467181750914 LHGVNINVEASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHGVNINVEASK 12 0 Q9BQ04;E9PLB0;E9PM61;U3KQD5;Q9BWF3;E9PB51;D6R9K7;J3QRR5;Q9BWF3-3;Q9BWF3-4;Q9BWF3-2 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 0 30206400.0 6754400.0 13580000.0 9872000.0 False True 10246918.612783585 11156542.89897573 7920794.872948688 1.0 1.0887705192717487 0.7729928549512503 23.288686801220255 -6.831650287437169 1.3205777407461419 1.0473806221862298 0.7642088527881032 0.909126386270734 0.04008398755165536 0.1787823288724961 0.6091906014090382 0.023828508560098004 0.054833276109392884 1.4734985491357295e-07 6.831650287437169 -0.2831717693981266 LHGVNINVEASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHGVNINVEASK 12 0 Q9BQ04;E9PLB0;E9PM61;U3KQD5;Q9BWF3;E9PB51;D6R9K7;J3QRR5;Q9BWF3-3;Q9BWF3-4;Q9BWF3-2 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 0 14264400.0 5502100.0 4034400.0 4727900.0 False True 7536375.058661689 3856146.86802328 3611267.3941569803 1.0 0.5116713059007516 0.47917830071454404 22.84543933387769 -13.999999999999998 0.3850701256969608 8.482195789774433 0.4765734550276514 0.9998155633103797 0.003235317701267282 24.68883743666782 0.2028850550951596 153.45129967903247 0.008675471580881522 1.0000000000000041e-14 13.999999999999998 -8.005622334746782 LHGVNINVEASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHGVNINVEASK 12 0 Q9BQ04;E9PLB0;E9PM61;U3KQD5;Q9BWF3;E9PB51;D6R9K7;J3QRR5;Q9BWF3-3;Q9BWF3-4;Q9BWF3-2 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 0 10895800.0 4732000.0 3797200.0 2366600.0 False True 3934867.663143984 3776743.7299148133 2861445.118077935 1.0 0.9598146756725159 0.7272023770658712 21.907883685378057 -6.936599014345401 0.6904763819877104 1.0028271762936116 0.6702892181538268 0.9976836642751128 0.005787457682470345 0.08935301039157427 0.06193500408549922 0.005497841838947303 0.020338497437000704 1.15718017771515e-07 6.936599014345401 -0.3325379581397848 LHGVNINVEASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHGVNINVEASK 12 0 Q9BQ04;E9PLB0;E9PM61;U3KQD5;Q9BWF3;E9PB51;D6R9K7;J3QRR5;Q9BWF3-3;Q9BWF3-4;Q9BWF3-2 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 0 25663800.0 6754400.0 11976000.0 6933400.0 False True 8743703.949128963 11309525.072249915 5671592.342691667 1.0 1.2934478497955728 0.64864871634368 23.059813123312704 -6.782961908480995 1.5242217392380761 1.1655182650336189 0.6430485175382772 0.7777641938172624 0.12426211954206384 0.24600027322956966 1.1290031527051303 0.06419738149866751 0.15111514022303 1.648306956480823e-07 6.782961908480995 -0.5224697474953417 LHICLYYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHICLYYR 8 0 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 0 18212200.0 3372500.0 7884400.0 6955300.0 False True 4421380.159336458 6708078.253150489 6235632.275948703 1.0 1.5171910153406056 1.410336150982439 22.07606535482859 -10.021896859816506 4.735977245395171 0.9999896065693872 1.4637635831420779 0.961708698735448 0.043623315752948706 30130780.87893126 1.2318138274167318 3553.5054276121477 0.014933421286739837 9.508305786943796e-11 10.021896859816506 0.4637739765726907 LHICLYYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHICLYYR 8 0 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 0 518157000.0 105600000.0 185017000.0 227540000.0 False True 160202920.39410576 151999270.80558094 182566619.2656751 1.0 0.9487921345731807 1.1395960748814924 27.255325206469063 -6.835261953149192 1.304055700812993 0.9727190807831544 1.1453112755230288 0.9160140033822552 0.0233677802473262 0.17441479424480158 0.578161646214326 0.014060323535237075 0.032365446535893905 1.4612954998300556e-07 6.835261953149192 0.17259219473987442 LHICLYYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHICLYYR 8 0 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 0 30029000.0 3372500.0 10815000.0 15841500.0 False True 4619404.388385625 10337157.539577564 12100063.965933662 1.0 2.237768480622274 2.6193991581157836 22.13927541635148 -10.109997757930241 0.27880813611506633 1.0076910585864853e-12 2.779637431992056 0.9989923023453583 0.021942519138344326 1.5654970850157643 0.12796483166193864 1.353376264460265 0.14912876315387344 7.762511240585593e-11 10.109997757930241 2.7796374319910484 LHICLYYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHICLYYR 8 0 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 0 417510000.0 105600000.0 175170000.0 136740000.0 False True 136701281.6871994 165421635.51319447 111854723.07088254 1.0 1.210095717256793 0.8182419483588245 27.026451528561513 -6.761033855776738 1.608330033266003 1.1218741862227706 0.8167232571416682 0.6953065792020516 0.08838084558183733 0.28116456354330593 1.4336168145451238 0.04335067693366869 0.10408277047069225 1.7336688429327314e-07 6.761033855776738 -0.3051509290811024 LHIFSGAHGPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHIFSGAHGPEK 12 0 Q14676-3;Q14676;Q14676-2;Q14676-4;A2AB06;A2AB07;A0A087X0R2;A2AB05 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 0 5253500.0 1570700.0 1288300.0 2394500.0 False True 2059202.910680437 1096090.6617540687 2146740.109665893 1.0 0.5322888075133303 1.0425102346793647 20.973654567244292 -6.665644923403774 1.9530820712271106 0.7003444925280717 1.0404006291102128 0.2597707351087075 0.19887641914056867 0.4712060980878083 3.461021233421291 0.08210531321117505 0.2205964692387577 2.1595092895815846e-07 6.665644923403774 0.34005613658214107 LHIFSGAHGPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHIFSGAHGPEK 12 0 Q14676-3;Q14676;Q14676-2;Q14676-4;A2AB06;A2AB07;A0A087X0R2;A2AB05 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 0 4663600.0 1570700.0 1579200.0 1513700.0 False True 2151430.236571475 1509425.7222839487 1156195.235630073 1.0 0.7015917581828606 0.5374077281132708 21.036864628767184 -13.354552654867309 0.07664255869869856 2.514727101377688 2.784517416521943e-20 0.9999141920731954 0.0017737571049922544 9.835663604601258 0.07059259815754984 2.7459353724705924 0.4603795578802151 4.420255214302613e-14 13.354552654867309 -2.514727101377688 LHIIEVGTPPTGNQPFPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHIIEVGTPPTGNQPFPK 18 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 16992800.0 6217800.0 0.0 10775000.0 False True 8151596.013260852 0.0 9660106.361098353 1.0 0.0 1.1850570545183405 22.958651123758813 -10.758781510058682 6.19732544908392 1.0130373019014183 0.5925285272591703 0.1361704008010891 0.4837975166092534 0.08692792495617394 0.0033834924045925635 0.4672519663890755 0.15614497706367875 1.7426833824047116e-11 10.758781510058682 -0.420508774642248 LHIIEVGTPPTGNQPFPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHIIEVGTPPTGNQPFPK 18 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 24617400.0 6217800.0 6784600.0 11615000.0 False True 8516688.689726947 6484833.938328062 8871776.21843384 1.0 0.7614266735087122 1.0416931440895814 23.021861185281704 -6.681250378054092 1.8976524515010071 0.8492173041384706 1.0406307447884289 0.3297182743069098 0.10108626685502922 0.4357781962679765 3.035165709459172 0.04272879078999114 0.11250554447743716 2.0832894854821347e-07 6.681250378054092 0.19141344064995824 LHIIEVGTPPTGNQPFPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHIIEVGTPPTGNQPFPK 18 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 11188500.0 3328600.0 3779300.0 4080600.0 False True 2767878.381982473 3758940.1607676833 4933834.593437345 1.0 1.3580582821978504 1.7825330135724824 21.40034912300494 -6.968872449936721 0.28382892455103564 0.9106939444791785 2.2429001251394927 0.9999722024547792 0.001686353062190526 0.07667030606310533 0.010333672742669314 0.00767161819820362 0.03877668284880437 1.074304883850635e-07 6.968872449936721 1.332206180660314 LHIQNPSFSQINQLVSTIMSASTTTLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHIQNPSFSQINQLVSTIMSASTTTLR 27 0 P23258;Q9NRH3;K7EIS0 P23258 TUBG1;TUBG2 Tubulin gamma-1 chain;Tubulin gamma-2 chain;Tubulin gamma chain 0 1954290000.0 826740000.0 590610000.0 536940000.0 False True 1254225022.7899904 485211031.04300815 430813573.6508382 1.0 0.3868612268344551 0.34348985694170314 30.224149061886504 -13.999999999999998 0.37606719678586786 9.873390689445305 0.3394142351008527 0.9998011029854065 0.004227853891777052 23.5456821063955 0.199611039426832 168.8704306320074 0.011896212940388303 1.0000000000000041e-14 13.999999999999998 -9.533976454344453 LHIQNPSFSQINQLVSTIMSASTTTLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LHIQNPSFSQINQLVSTIMSASTTTLR 27 0 P23258;Q9NRH3;K7EIS0 P23258 TUBG1;TUBG2 Tubulin gamma-1 chain;Tubulin gamma-2 chain;Tubulin gamma chain 0 1846307000.0 910665000.0 381682000.0 553960000.0 False True 1178873794.3908453 360441061.17455673 453144964.1095954 1.0 0.3057503380680423 0.38438802038495323 30.13476213129266 -10.534878829035108 6.314102076034087 1.00075748297716 0.3450691792331532 0.9893030204541433 0.032103699371919266 0.0003426813385574436 2.524323241909128e-05 0.03111643270531013 0.010361424418257732 2.9182411085407883e-11 10.534878829035108 -0.6556883037440067 LHISPSNMTNQNTNEYLEK(ub)IK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHISPSNMTNQNTNEYLEKIK 21 1 Q13547 Q13547 HDAC1 Histone deacetylase 1 1 14166200.0 2680200.0 5179600.0 6306400.0 True False 3513768.1550937183 4406823.869922666 5653874.223260384 1.0 1.2541589756097975 1.6090629699242593 21.74458757213001 -6.966419387879055 0.332792525060086 0.9581453600547302 1.9167435468907021 0.9999394848170201 0.001943069192536475 0.07748254702219706 0.013179285470894024 0.0051283458723015195 0.030886835487576435 1.0803901402573065e-07 6.966419387879055 0.958598186835972 LHISPSNMTNQNTNEYLEK(ub)IK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHISPSNMTNQNTNEYLEKIK 21 1 Q13547 Q13547 HDAC1 Histone deacetylase 1 1 13796000.0 3267800.0 4041900.0 6486300.0 True False 3164065.477703285 5655851.748230054 4787343.445171011 1.0 1.7875267715178556 1.5130355167763538 21.59334802481768 -10.085506231675735 4.531602555285722 0.9999560157368272 1.650281144175547 0.8821191596883665 0.11206058560022714 77891913.8593547 3.692219264296791 37925.99196151438 0.038361319072067655 8.212847681647192e-11 10.085506231675735 0.6503251284387197 LHISPSNMTNQNTNEYLEK(ub)IK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHISPSNMTNQNTNEYLEKIK 21 1 Q13547 Q13547 HDAC1 Histone deacetylase 1 1 43491000.0 11547000.0 12536000.0 19408000.0 True False 17517643.19877591 10298852.855784945 15572000.293171423 1.0 0.5879131535516492 0.888932381854858 24.062305353867877 -10.495665595027859 5.546918748012694 1.0004169634371507 0.7384227677032532 0.501698230618928 0.12289058535153784 0.0006346722030774637 5.7705502794901224e-05 0.11917457767921419 0.03966276587268204 3.193996272540467e-11 10.495665595027859 -0.2619941957338975 LHISPSNMTNQNTNEYLEK(ub)IK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHISPSNMTNQNTNEYLEKIK 21 1 Q13547 Q13547 HDAC1 Histone deacetylase 1 1 9451600.0 2680200.0 3723200.0 3048200.0 True False 3671142.3696815837 3558696.713024059 2328277.939649592 1.0 0.9693703906483807 0.6342107456463301 21.8077976336529 -6.924768747616249 0.7885495356208148 1.006203387750565 0.5737537905997038 0.9954063583645291 0.011229720726112977 0.09544657219719808 0.09166435661000559 0.009928548430993351 0.031243719442447908 1.1891352475923689e-07 6.924768747616249 -0.4324495971508612 LHISPSNMTNQNTNEYLEK(ub)IK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHISPSNMTNQNTNEYLEKIK 21 1 Q13547 Q13547 HDAC1 Histone deacetylase 1 1 62198300.0 11547000.0 9583300.0 41068000.0 True False 14947819.12539857 9049980.93060225 33594045.39326466 1.0 0.6054382150788128 2.247421186424672 23.833431675960327 -6.843266210817213 1.2671885900734996 0.7901116504984943 2.3049981147700276 0.9299176390156154 0.1852662657664951 0.16501887835845602 0.5133196015736428 0.1145771442006536 0.2642335328863612 1.4346097866315013e-07 6.843266210817213 1.5148864642715334 up LHITQK(ub)DNYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHITQKDNYR 10 1 Q15080;A0A494BZS1 Q15080 NCF4 Neutrophil cytosol factor 4 1 7718500.0 1451500.0 1178300.0 5088700.0 True False 1878995.3633425157 1112726.5691910542 4162608.814471259 1.0 0.592192291103711 2.2153374594104687 20.841530076054994 -6.840147747595273 1.2817556395696976 0.7830680681361973 2.2688671200121635 0.9247079912112043 0.18917823381170773 0.16861944730217107 0.5380666105220012 0.11573202746669117 0.2666277008683738 1.4449481137332167e-07 6.840147747595273 1.4857990518759663 up LHITVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHITVSK 7 0 Q9HB90 Q9HB90 RRAGC Ras-related GTP-binding protein C 0 5176700.0 1667500.0 1014300.0 2494900.0 False True 2186108.648092972 862970.3937104337 2236751.680770699 1.0 0.3947518319655505 1.0231658352030695 21.059933673064908 -10.9569924342216 12.712318625343128 1.0826472757365246 0.7089588335843189 0.22239097752117387 0.2565489425252696 0.11290321798509574 0.0003819670411175787 0.04666988638211992 0.08280081515729104 1.1040978540560455e-11 10.9569924342216 -0.37368844215220576 LHIVK(ub)VVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHIVKVVAK 9 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 1 10914570.0 2187670.0 5475800.0 3251100.0 True False 2868056.555426419 4658831.984501227 2914707.3587533003 1.0 1.6243863726071321 1.0162656497266824 21.45164204225826 -10.143315118974716 4.207831561826187 0.9999250630640286 1.3203260111211776 0.2700465827406905 0.24826424565134833 86777250.3896413 10.321624510902403 66908.4149575799 0.08498745470756505 7.189271436174686e-11 10.143315118974716 0.320400948057149 LHIVK(ub)VVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHIVKVVAK 9 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 1 25937500.0 4928300.0 7799200.0 13210000.0 True False 4771853.814115028 10913461.232290694 9749904.70849469 1.0 2.287048526090414 2.0432111058504576 22.186118416028364 -10.162024473062578 4.997224907719404 0.9999243498816677 2.1651298159725805 0.9681963628888003 0.09954620997154875 8.390823412462812e-05 1.4070526075678255e-05 0.09639138642709037 0.0321284011154212 6.886134909792582e-11 10.162024473062578 1.1652054660909128 LHIVK(ub)VVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHIVKVVAK 9 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 1 10949470.0 2187670.0 4434500.0 4327300.0 True False 2996510.71855881 4238569.127069508 3305280.863541002 1.0 1.4145015737197406 1.1030432306047937 21.514852103781152 -10.091252158664345 6.382249122671481 0.9999995897365754 1.2587724021622684 0.4792740606495567 0.12715233612738908 7.422766498684888e-07 1.0578048315794105e-07 0.12311491635604296 0.041038240021061406 8.104903369218957e-11 10.091252158664345 0.25877281242569294 LHIVK(ub)VVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHIVKVVAK 9 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 1 21354390.0 4928300.0 14134500.0 2291590.0 True False 4098099.8107084692 14058354.643021401 2770750.873884988 1.0 3.4304568683970214 0.6761062448125166 21.96652369146264 -6.67370211803769 1.9240285822268277 2.5463032448848675 0.6869386630766818 0.29578737756490436 1.031515488075051 0.452577792826819 3.233362511937824 0.43105194053255297 1.1462242752342082 2.1198146145258903e-07 6.67370211803769 -1.8593645818081856 LHIVQVVCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHIVQVVCK 9 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 355678000.0 98034000.0 102753000.0 154891000.0 False True 128523523.36260654 87422652.92805696 138864365.1393861 1.0 0.6802074098249649 1.0804587479881382 26.937457195815167 -6.693888559769019 1.8525882456570615 0.8002535173963303 1.0791471997234117 0.38881400755548134 0.13514338488265423 0.4082952093562146 2.7197966344868982 0.05829346479761665 0.15106097473060934 2.0235383532503102e-07 6.693888559769019 0.27889368232708134 LHIVQVVCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHIVQVVCK 9 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 11998000.0 8531700.0 1194700.0 2271600.0 False True 8260865.853516461 1671749.9402781953 1676599.8134607528 1.0 0.2023698205396435 0.20295691071500244 22.977861573378974 -10.073863092589358 4.85619811191728 1.0000253545240494 0.20266336561929732 0.9999995931453308 0.00023967858809126612 332810.51921178063 0.008455176957346287 94.372800760706 8.204835160362538e-05 8.436006533337165e-11 10.073863092589358 -0.7973619889047521 LHIVQVVCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHIVQVVCK 9 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 166471000.0 41145000.0 80005000.0 45321000.0 False True 62419973.10241921 65727482.66808191 36363284.48510004 1.0 1.0529880004952215 0.5825584773231937 25.895504399792678 -6.878910570725179 1.0858118941374018 1.032394313584006 0.5499022194584563 0.9727979848542316 0.0346994103528717 0.12860161864821334 0.2781295720158653 0.02464014916917345 0.05942696360118811 1.3215677414365463e-07 6.878910570725179 -0.4824920941255496 LHIVQVVCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHIVQVVCK 9 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 292466000.0 98034000.0 86676000.0 107756000.0 False True 134279819.06923544 82846367.72079761 82306252.10448179 1.0 0.6169681214574884 0.6129458073073826 27.00066725733806 LHIVQVVCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHIVQVVCK 9 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 36498900.0 8531700.0 1962500.0 26004700.0 False True 7094486.5683950735 1951927.6229742514 31442162.537852254 1.0 0.27513303523186733 4.431915154779855 22.75826684881325 -6.8619152455027805 1.1761100524596577 0.6045785712660732 4.6406097163309274 0.9559212081140019 0.38063580502197436 0.1448365692132051 0.3796211519310477 0.2522320791206695 0.5900768367561977 1.374310151574316e-07 6.8619152455027805 4.036031145064854 up LHIVQVVCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHIVQVVCK 9 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 139458000.0 41145000.0 57204000.0 41109000.0 False True 53263013.58920273 54020547.113642596 33627583.813960135 1.0 1.0142225058890288 0.6313496279672952 25.666630721885127 -6.898273246417443 0.9721347890398211 1.016681402678409 0.5925428199134356 0.9856870227045343 0.021203342744462773 0.112686972523526 0.184681569519247 0.016410371282271723 0.042338152867304905 1.2639408596239556e-07 6.898273246417443 -0.4241385827649734 LHK(ub)QADMQEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHKQADMQEEK 11 1 E9PLK3;P55786;P55786-2;H0YDG0 E9PLK3 NPEPPS Puromycin-sensitive aminopeptidase 1 2041120.0 415330.0 403790.0 1222000.0 True False 630085.9746901885 331730.5196743304 980471.1643783724 1.0 0.5264845322694913 1.5560910792538545 19.26518917098038 -6.781666517134343 1.529416572513273 0.7324588198275825 1.5646697376694298 0.7732070434197652 0.20038976354578888 0.24800686275878558 1.1459454456080402 0.10318625533427168 0.24313528706758694 1.653230781700915e-07 6.781666517134343 0.8322109178418473 LHK(ub)QADMQEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHKQADMQEEK 11 1 E9PLK3;P55786;P55786-2;H0YDG0 E9PLK3 NPEPPS Puromycin-sensitive aminopeptidase 1 2957670.0 880900.0 1532400.0 544370.0 True False 732507.3804868001 1524144.6570424153 658195.2501175045 1.0 2.080722594261807 0.8985510148445054 19.482483770132877 -6.666219568316625 1.9508989432669916 1.692057986231314 0.9034147709935938 0.2623460636262902 0.45947268930026686 0.46986461104167776 3.443983229171023 0.18985887226509093 0.5097460153439255 2.1566537838191941e-07 6.666219568316625 -0.7886432152377203 LHLELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHLELK 6 0 Q9Y6Y8;Q9Y6Y8-2 Q9Y6Y8 SEC23IP SEC23-interacting protein 0 43256200.0 14306700.0 11165000.0 17784500.0 False True 18756222.246279903 9499225.520829124 15944330.540970158 1.0 0.5064572916709384 0.850082193077689 24.16086594327021 -10.065584465558663 5.951034406070645 1.0000008846121735 0.6782697423742967 0.5389230188304328 0.14028427856018635 1.646478157891185e-06 2.584867374669143e-07 0.1358300410494937 0.04527655621651721 8.598358218993991e-11 10.065584465558663 -0.3217311422378768 LHLELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHLELK 6 0 Q9Y6Y8;Q9Y6Y8-2 Q9Y6Y8 SEC23IP SEC23-interacting protein 0 18960700.0 6867500.0 2279700.0 9813500.0 False True 6649494.971579448 3189996.098478446 7243049.951310569 1.0 0.479735094486541 1.0892631669424564 22.66481334156721 -6.680694096237315 1.8996880715312354 0.6710189840610862 1.0869395433991649 0.32716164675534953 0.220468676723237 0.43699717641399677 3.0497277578499755 0.09310911559010895 0.245326903334386 2.0859596519985666e-07 6.680694096237315 0.4159205593380787 LHLELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHLELK 6 0 Q9Y6Y8;Q9Y6Y8-2 Q9Y6Y8 SEC23IP SEC23-interacting protein 0 33751700.0 14306700.0 8217800.0 11227200.0 False True 19596273.614030153 7854710.423369454 8575566.591442134 1.0 0.40082673767862653 0.437612107298929 24.2240760047931 -10.287930793597164 7.3552565307782976 1.0000033617102564 0.4192194224887778 0.9970002664399185 0.015017564261569812 8.278509143752416e-07 8.015691355294234e-08 0.014540778093282816 0.004846898023804965 5.153107546794256e-11 10.287930793597164 -0.5807839392214786 LHLELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHLELK 6 0 Q9Y6Y8;Q9Y6Y8-2 Q9Y6Y8 SEC23IP SEC23-interacting protein 0 13192440.0 6867500.0 4064300.0 2260640.0 False True 5710630.531834598 4042404.809199614 2733329.3719816175 1.0 0.7078736378872248 0.47863880472468734 22.445218617001487 -7.294668078112654 0.16065232564124973 1.2538469613945946 7.854853796461251e-12 0.9999920772081832 0.000600527438203475 0.10697045512763663 0.009386935675167568 0.022477807503046187 0.046356633600535595 5.073783384266949e-08 7.294668078112654 -1.2538469613867398 down LHLGFIEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHLGFIEIR 9 0 Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 Q9Y383 LUC7L2 Putative RNA-binding protein Luc7-like 2 0 235126000.0 108030000.0 67829000.0 59267000.0 False True 141628376.16400802 57709177.59537111 53134619.369208 1.0 0.4074690338081891 0.37516930440321666 27.077535106791757 -13.781659861550315 0.4161655127230435 9.999469414905368 0.3739409680458892 0.9998561923434542 0.0034445451283617585 24.201635568851746 0.21434579184396663 196.498238798581 0.007917797073945021 1.6532561177370758e-14 13.781659861550315 -9.625528446859478 LHLGFIEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHLGFIEIR 9 0 Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 Q9Y383 LUC7L2 Putative RNA-binding protein Luc7-like 2 0 326233000.0 139630000.0 72963000.0 113640000.0 False True 135197522.0795979 102097506.39701857 83874274.87307623 1.0 0.7551729116522446 0.6203832258382297 27.01049346903086 -13.999999999575781 0.0717292389615903 2.397568871473607 0.14814851433321957 0.9999184289108657 0.0014191632935229457 12.342605227906308 0.07286360643809252 2.8567996557505113 0.43380933686495904 1.0000000009768e-14 13.999999999575781 -2.2494203571403877 LHLGFIEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHLGFIEIR 9 0 Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 Q9Y383 LUC7L2 Putative RNA-binding protein Luc7-like 2 0 395990000.0 113950000.0 137440000.0 144600000.0 False True 172870480.86087438 112912758.17637871 116019746.61956853 1.0 0.6531639040632422 0.6711368305439079 27.365116296375906 -10.79958449863347 10.774826834047932 1.0023403517098934 0.662150367306092 0.9978819734347327 0.0073374165103644775 0.0004139746641234825 7.700060031128356e-06 0.0071296101712581975 0.0023681409957357407 1.5864102285501146e-11 10.79958449863347 -0.34018998440380144 LHLGFIEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHLGFIEIR 9 0 Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 Q9Y383 LUC7L2 Putative RNA-binding protein Luc7-like 2 0 385760000.0 108030000.0 118140000.0 159590000.0 False True 147971610.40097803 112920184.16326348 121898128.85922128 1.0 0.763120600345356 0.8237940273063054 27.14074516831465 -10.32016204526312 6.011425682570256 1.0000169127597565 0.7934573138258305 0.9392140410144575 0.024769822833392578 5.615035515085673e-06 6.349694860018631e-07 0.02398524043166879 0.007994425943519666 4.784515377367147e-11 10.32016204526312 -0.20655959893392595 LHLGFIEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHLGFIEIR 9 0 Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 Q9Y383 LUC7L2 Putative RNA-binding protein Luc7-like 2 0 263108000.0 139630000.0 57690000.0 65788000.0 False True 116108531.65781797 57379212.51943163 79543966.63065621 1.0 0.49418601458619077 0.6850828745735865 26.790898744465135 -10.277426586930284 5.171026719928455 1.0000752875398111 0.5896344445798133 0.8603634841295009 0.07793331674505398 6.76559224608528e-05 9.453787518852482e-06 0.07547239201809353 0.02515286982231818 5.279264398402939e-11 10.277426586930284 -0.41044084295999783 LHLGFIEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHLGFIEIR 9 0 Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 Q9Y383 LUC7L2 Putative RNA-binding protein Luc7-like 2 0 384190000.0 113950000.0 167960000.0 102280000.0 False True 147510521.29030645 158612878.3512939 83666089.48142368 1.0 1.0752648486621341 0.5671872673866127 27.136242618468355 -6.86921603582162 1.1381521308388685 1.042377017259271 0.5378612378688242 0.9638987834993954 0.04253952869822638 0.13761314259118168 0.3336487033373079 0.0290188519219284 0.06861558495239724 1.3514001543080874e-07 6.86921603582162 -0.5045157793904468 LHLGFIQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHLGFIQIR 9 0 A8MYV2;Q9NQ29-2;Q9NQ29-3;Q9NQ29;B8ZZ10 A8MYV2 LUC7L Putative RNA-binding protein Luc7-like 1 0 39973500.0 13350800.0 12093100.0 14529600.0 False True 17503028.089331094 10288856.618534604 13026216.369764695 1.0 0.5878329490201835 0.7442264448918285 24.061101199500378 -10.196290910171214 4.939450288761217 1.0000357953176193 0.666029696955448 0.8587608268927397 0.06384737733119925 2.5170772143967567e-05 4.095589610142494e-06 0.06182657246077813 0.02060665242495362 6.363691091733607e-11 10.196290910171214 -0.3340060983621713 LHLGFIQIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHLGFIQIR 9 0 A8MYV2;Q9NQ29-2;Q9NQ29-3;Q9NQ29;B8ZZ10 A8MYV2 LUC7L Putative RNA-binding protein Luc7-like 1 0 54898100.0 20411300.0 18486300.0 16000500.0 False True 19763354.45408074 25867975.99478095 11809489.04528912 1.0 1.308885900664486 0.597544767652067 24.236324502001597 -6.788683198233866 1.5015341166004454 1.1729325838089337 0.5902456258923732 0.7970440817799491 0.13120547638806168 0.23732188922206832 1.0570571885671929 0.06878346389628584 0.16119863729146952 1.6267349660574118e-07 6.788683198233866 -0.5826869579165606 LHLGFIQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHLGFIQIR 9 0 A8MYV2;Q9NQ29-2;Q9NQ29-3;Q9NQ29;B8ZZ10 A8MYV2 LUC7L Putative RNA-binding protein Luc7-like 1 0 87436500.0 21210900.0 26205200.0 40020400.0 False True 32178486.024501268 21528677.317837887 32110350.398435567 1.0 0.6690394725670303 0.9978825720385408 24.939593114066373 -10.927069936557276 10.091365571678766 1.0305880620869605 0.8334610223027856 0.2548290672332344 0.1342496331900822 0.07275027172331693 0.0005257637826934913 0.10235674238841368 0.04332888279830359 1.1828510601156498e-11 10.927069936557276 -0.1971270397841749 LHLGFIQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHLGFIQIR 9 0 A8MYV2;Q9NQ29-2;Q9NQ29-3;Q9NQ29;B8ZZ10 A8MYV2 LUC7L Putative RNA-binding protein Luc7-like 1 0 86202900.0 13350800.0 25192100.0 47660000.0 False True 18286951.551803917 24079029.72286566 36403689.588511124 1.0 1.3167328438889194 1.990692078194962 24.12431126102327 -6.958815450672976 0.4518248391624662 0.97866703225233 2.3555569382311448 0.9997236924168124 0.0068670819924052644 0.0801271070293461 0.022716126343321017 0.009032981470360815 0.05573275460933284 1.09947295079591e-07 6.958815450672976 1.3768899059788149 LHLGFIQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHLGFIQIR 9 0 A8MYV2;Q9NQ29-2;Q9NQ29-3;Q9NQ29;B8ZZ10 A8MYV2 LUC7L Putative RNA-binding protein Luc7-like 1 0 46776000.0 20411300.0 11119900.0 15244800.0 False True 16972900.3239076 11059994.891572664 18432417.19600882 1.0 0.6516266919916942 1.0859910118039982 24.016729777435874 -6.693181421594849 1.8552035867279644 0.7822435064656843 1.0845455149748948 0.38529157528436664 0.14724408061650007 0.40987884626641574 2.737553373232358 0.0634370543443432 0.1645294940538763 2.0268358549557856e-07 6.693181421594849 0.3023020085092105 LHLGFIQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHLGFIQIR 9 0 A8MYV2;Q9NQ29-2;Q9NQ29-3;Q9NQ29;B8ZZ10 A8MYV2 LUC7L Putative RNA-binding protein Luc7-like 1 0 90651900.0 21210900.0 44936600.0 24504400.0 False True 27457928.179346725 42435838.70755393 20044850.636376597 1.0 1.5454858221777008 0.7300205064799431 24.710719436158822 -6.72636563255699 1.7359240386040102 1.3295701466445828 0.7307646555605295 0.5426621856528003 0.22938083311325902 0.3430553217296658 2.0234148370227647 0.1047756015996174 0.2611255349031725 1.877735285672808e-07 6.72636563255699 -0.5988054910840533 LHLGHTFSLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHLGHTFSLSK 11 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 97555000.0 23694000.0 27256000.0 46605000.0 False True 31063063.453022372 23189511.043055873 41782761.666727476 1.0 0.746530073510814 1.3450946887423654 24.888696780174463 -6.791704728282905 1.4899925681725965 0.8586478623717784 1.3517197593181312 0.8066490107053595 0.10786935110529973 0.23282613393397356 1.021166608911921 0.05698419511650855 0.13322264649569288 1.615456513448895e-07 6.791704728282905 0.4930718969463528 LHLGHTFSLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHLGHTFSLSK 11 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 55807400.0 24596000.0 5556400.0 25655000.0 False True 23815213.44316974 7775099.496243207 18935185.866497464 1.0 0.326476162592325 0.7950878085423215 24.50538014308448 -10.054252030494789 5.946773927213692 1.0000010435919886 0.5607819855676488 0.5394491184713865 0.19130990335065212 2.6469156742510092e-06 4.207572867687289e-07 0.18523545762681334 0.061745005803452935 8.82567578694666e-11 10.054252030494789 -0.4392190580243398 LHLGHTFSLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHLGHTFSLSK 11 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 44174000.0 14050000.0 10763000.0 19361000.0 False True 21314877.19258696 8842258.558297185 15534289.863772262 1.0 0.41483976090523333 0.7288003455715376 24.345357407331534 -10.211781362817065 5.3544991804162985 1.000025769741663 0.5718200532383377 0.7126387007751969 0.12817387196330463 3.943268039853714e-05 5.805010257602069e-06 0.12411127465142939 0.04136793929436376 6.140710696015958e-11 10.211781362817065 -0.4282057165033253 LHLGHTFSLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHLGHTFSLSK 11 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 63660000.0 23694000.0 16044000.0 23922000.0 False True 32454312.10627395 15335123.029586907 18272116.28905502 1.0 0.4725141910070674 0.5630104323031614 24.951906841697355 -10.825662012080123 7.353784698513775 1.0251893592762125 0.5177623116551158 0.9742677139781388 0.036944935802535626 0.013584067585926247 0.00032204044588125705 0.03184825024437675 0.011923926757493548 1.4939566229616113e-11 10.825662012080123 -0.5074270476210967 LHLGHTFSLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHLGHTFSLSK 11 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 45642000.0 24596000.0 10013000.0 11033000.0 False True 20452663.78755061 9959057.981575107 13339949.289171722 1.0 0.4869320732508748 0.6522352994083662 24.285785418518756 -10.416957678851592 5.21123932689494 1.0003940176263737 0.5695836863296081 0.9003953276478457 0.06748475948700185 0.00030920870967945783 3.459475315425321e-05 0.065400176133515 0.021780612467991164 3.828620506575403e-11 10.416957678851592 -0.4308103312967656 LHLGHTFSLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHLGHTFSLSK 11 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 70790000.0 14050000.0 34360000.0 22380000.0 False True 18188001.96690482 32447835.795132544 18307069.63819183 1.0 1.784024207506418 1.0065464954041499 24.116483729423983 -10.223512935954345 3.763877018678199 0.9995640757378524 1.395285350172978 0.25631467783155315 0.3174039482271166 225410411.41138184 411810452.63223946 1269295.668217748 0.1161579061870834 5.97705241094168e-11 10.223512935954345 0.3957212744351256 LHLIYLINDVLHHCQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHLIYLINDVLHHCQR 16 0 Q8IWX8 Q8IWX8 CHERP Calcium homeostasis endoplasmic reticulum protein 0 72553500.0 30590500.0 30362000.0 11601000.0 False True 46408024.96511262 24943663.880611237 9308057.265101071 1.0 0.5374860037539352 0.20056999348923885 25.467870964743373 -8.097182814644265 0.30093155572980185 1.1326837992618106 8.853478933864091e-17 0.9990832248733766 0.009922371644645893 0.09169952574973063 0.06305707519141335 0.06809658096596517 0.09254345751581797 7.994976386107128e-09 8.097182814644265 -1.1326837992618106 down LHLIYLINDVLHHCQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHLIYLINDVLHHCQR 16 0 Q8IWX8 Q8IWX8 CHERP Calcium homeostasis endoplasmic reticulum protein 0 26365560.0 17484800.0 328160.0 8552600.0 False True 14539385.907975448 326392.1369453403 10340909.117245547 1.0 0.022448825487622615 0.7112342421266318 23.793463000440994 -10.506195282727868 8.377919810985949 1.0000461802301353 0.3668415351588552 0.529780702366687 0.2811954688393151 0.00024256814550026535 1.4296920706897138e-05 0.272285981100304 0.09075544732030454 3.117487474748447e-11 10.506195282727868 -0.63320464507128 LHLIYLINDVLHHCQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHLIYLINDVLHHCQR 16 0 Q8IWX8 Q8IWX8 CHERP Calcium homeostasis endoplasmic reticulum protein 0 69382500.0 30590500.0 26099700.0 12692300.0 False True 39600005.27890411 24647228.751519807 10382431.633995643 1.0 0.6224046834824537 0.26218258206967004 25.238997286835822 -7.559627556038207 0.30679222337843076 1.0871072936520405 6.133009693980631e-15 0.9996102818383336 0.005946871100075321 0.1255353584948434 0.035543570183895805 0.025579246162077362 0.0692153934420232 2.7565916986592928e-08 7.559627556038207 -1.0871072936520343 down LHLLSVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHLLSVLK 8 0 Q92797;A0A087WUE9;M0R3C7;Q92797-2 Q92797 SYMPK Symplekin 0 10217700.0 3286300.0 3163500.0 3767900.0 False True 4308371.124574475 2691518.1312264195 3378033.8522489504 1.0 0.6247182643747415 0.784062875405746 22.03871109880747 -10.17041936816953 5.31298858845507 1.0000115655385617 0.7043905712949478 0.8210711902041976 0.06505216504839183 8.91219349023001e-06 1.3916288898106796e-06 0.06298895049915966 0.020995495988878583 6.75430443885926e-11 10.17041936816953 -0.295620994243614 LHLLSVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHLLSVLK 8 0 Q92797;A0A087WUE9;M0R3C7;Q92797-2 Q92797 SYMPK Symplekin 0 9020100.0 3286300.0 2667100.0 3066700.0 False True 4501333.918918218 2549258.7030797377 2342408.620669053 1.0 0.5663340576369388 0.5203809943591102 22.101921160330363 -13.999999999999998 0.31708089914437376 5.37026550544829 0.5109577865211558 0.9996874396770304 0.003820142065329074 17.789654485125773 0.17945068080856885 51.49363774766198 0.015476350325242 1.0000000000000041e-14 13.999999999999998 -4.859307718927134 LHLLSVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHLLSVLK 8 0 Q92797;A0A087WUE9;M0R3C7;Q92797-2 Q92797 SYMPK Symplekin 0 3784600.0 0.0 1765100.0 2019500.0 False True 0.0 1755591.0559550803 2441768.1128870063 0.0 LHLSGIDANPNALFPPVEFPAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHLSGIDANPNALFPPVEFPAPR 23 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 4441570.0 779520.0 2814900.0 847150.0 False True 1021958.2688824179 2394927.8923942614 759495.0444366095 1.0 2.3434693620252034 0.743176182005132 19.962904855124567 -6.6840180722252125 1.8873567646763745 1.8469201325553826 0.7490203807383353 0.34275287363840423 0.5688968070088679 0.4296391745736013 2.9622026145884903 0.24154987708323183 0.6338701968060353 2.0700552061301617e-07 6.6840180722252125 -1.0978997518170472 LHLSGIDANPNALFPPVEFPAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHLSGIDANPNALFPPVEFPAPR 23 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 14023800.0 6348500.0 2759600.0 4915700.0 False True 6146970.342493205 3861522.671123886 3628130.7021610443 1.0 0.6281993333251802 0.5902307152972984 22.551444093789122 -13.999999999999998 0.32243445052300745 4.867865391850462 0.5828958867100232 0.9996989293665776 0.0032077247012563047 18.204348452201213 0.18120110291189195 47.5602599107731 0.012522139876757698 1.0000000000000041e-14 13.999999999999998 -4.284969505140439 LHLSGIDANPNALFPPVEFPAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHLSGIDANPNALFPPVEFPAPR 23 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 6691120.0 779520.0 2634000.0 3277600.0 False True 1067729.6097359112 2517621.170526798 2503498.384290893 1.0 2.357920158409298 2.3446932270709437 20.026114916647458 -10.473412726858433 6.110569793402276 0.9991815247438024 2.3513066927401196 0.9999281476632876 0.005399872106966442 6.02389745455734e-05 5.191187389017308e-06 0.005230871751107653 0.0017428012284941702 3.361919213151967e-11 10.473412726858433 1.3521251679963173 LHLSGIDANPNALFPPVEFPAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHLSGIDANPNALFPPVEFPAPR 23 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 11799100.0 6348500.0 2455300.0 2995300.0 False True 5279059.036236172 2442072.8115611076 3621603.381297572 1.0 0.4625962306536811 0.6860319910117313 22.3318493692234 -10.269681833249741 5.633123328102565 1.0000327428857083 0.5743141108326998 0.8287561820727798 0.09121726719469588 3.751268753103613e-05 4.863343716309758e-06 0.08832751692575086 0.029440246394296637 5.3742537324597166e-11 10.269681833249741 -0.4257186320530085 LHMTIFSQSVSPCGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHMTIFSQSVSPCGK 15 0 Q86W42;Q86W42-3 Q86W42 THOC6 THO complex subunit 6 homolog 0 24390600.0 7083500.0 8583000.0 8724100.0 False True 9286537.09671158 7302449.856271955 7821413.819476388 1.0 0.7863479982067587 0.8422314731554779 23.146709292437905 -10.372305476849219 5.869820360299863 1.000038404473543 0.8142897356811181 0.9364054066324812 0.022814333112995612 1.1468460555906034e-05 1.2264171692835948e-06 0.022094445014012993 0.007363294350121573 4.243209973193542e-11 10.372305476849219 -0.18574866879242502 LHMTIFSQSVSPCGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHMTIFSQSVSPCGK 15 0 Q86W42;Q86W42-3 Q86W42 THOC6 THO complex subunit 6 homolog 0 17817500.0 7528500.0 3046400.0 7242600.0 False True 7289511.888392544 4262843.406766129 5345545.786657358 1.0 0.5847913374768026 0.7333201273969164 22.797390783084655 -10.152179235840064 6.258347373885188 1.0000016854913962 0.6590557324368582 0.8753989282742058 0.06063662456955744 1.4260386644758015e-06 1.9319391431497424e-07 0.058711449702781644 0.019570386427343253 7.044022980746056e-11 10.152179235840064 -0.340945953054538 LHMTIFSQSVSPCGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHMTIFSQSVSPCGK 15 0 Q86W42;Q86W42-3 Q86W42 THOC6 THO complex subunit 6 homolog 0 31344500.0 7083500.0 10792000.0 13469000.0 False True 9702461.374389792 10315173.755628407 10287899.6027624 1.0 1.0631502005105535 1.060339145478889 23.209919353960796 -10.565386783690638 5.76026143266009 0.9998063070797869 1.0617446729947213 0.9984478369468827 0.0011476084110768545 2.8635796191227066e-06 2.1605616427246329e-07 0.0011146460013230378 0.00037038902200568037 2.7202775433321187e-11 10.565386783690638 0.0619383659149344 LHMTIFSQSVSPCGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHMTIFSQSVSPCGK 15 0 Q86W42;Q86W42-3 Q86W42 THOC6 THO complex subunit 6 homolog 0 38821600.0 6701600.0 15221000.0 16899000.0 False True 8675353.308285374 14373937.969665674 13823555.398382679 1.0 1.6568706148184054 1.5934285218309814 23.048491082719032 -10.248727564889682 4.663275391394542 0.9998038475772008 1.6251495683271264 0.9923350951278986 0.025900126013894586 5.283511366840384e-05 8.5119200277132e-06 0.025085443715764728 0.00835922972519625 5.639913394812401e-11 10.248727564889682 0.6253457207499257 LHMVLRPFLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHMVLRPFLLR 11 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 8733300.0 2192300.0 4240800.0 2300200.0 False True 2122706.636504348 5934173.555479845 1697708.6154791426 1.0 2.795569323348507 0.7997848531132461 21.017473570192983 -6.669610405413034 1.938528143969642 2.1464593614367815 0.8078210098811238 0.27745317068707576 0.7627815727147353 0.4619908592914786 3.3466217721062956 0.3168030484144796 0.8469182570975171 2.139880861689485e-07 6.669610405413034 -1.3386383515556577 LHMVLRPFLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHMVLRPFLLR 11 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 129562000.0 17674000.0 36496000.0 75392000.0 False True 26812750.142475564 29983003.65545051 60490738.1545125 1.0 1.1182367901885892 2.256043778914188 24.676415866129105 -6.926829494292735 0.7723655502628598 0.9805133301827207 2.4718317528871294 0.995877844665281 0.03635853988017648 0.09431728717760444 0.08598985670923018 0.032520077770760346 0.10480341897509164 1.183506113641247e-07 6.926829494292735 1.4913184227044087 up LHMVLRPFLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHMVLRPFLLR 11 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 21212200.0 2380900.0 7780300.0 11051000.0 False True 3261183.0714032114 7436540.619988471 8440981.402489224 1.0 2.280319889183253 2.5883187842187794 21.636964000533865 -10.298365254611001 0.3165971119974514 7.909854794108233e-16 2.674449350299347 0.9989991612616679 0.021757269468543613 1.7662025591416148 0.14844738939097654 1.5908525669529676 0.10295855136021012 5.030773277812231e-11 10.298365254611001 2.674449350299346 LHMVLRPFLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHMVLRPFLLR 11 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 16117700.0 2192300.0 6379700.0 7545700.0 False True 1822994.5853572588 6345331.289828706 9123470.982625151 1.0 3.480718670694893 5.004661591376692 20.79787884562726 -8.416462814439804 0.2686194090871646 4.814551206703495e-15 6.063922375900184 0.9991742056274139 0.047426270293089406 0.13668146359104041 0.06992181257259038 0.5981366775456705 0.5373246486625174 3.832985581355088e-09 8.416462814439804 6.063922375900179 LHMVLRPFLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHMVLRPFLLR 11 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 113473000.0 17674000.0 58474000.0 37325000.0 False True 22879341.406624597 55219870.49722293 30532232.98684142 1.0 2.4135253509191616 1.334489155269171 24.447542188221554 -10.252830847678135 5.675007590299294 0.9999497282035021 1.8740072530941827 0.46660290016635597 0.44051468222279766 0.0002802062912793421 3.689211071710079e-05 0.4265508543874467 0.14217550233405382 5.586877543265323e-11 10.252830847678135 0.8740575248906806 LHNFHQLSAPQPCFTFSHPNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHNFHQLSAPQPCFTFSHPNR 21 0 O14744-2;O14744;O14744-3;O14744-5;O14744-4;H0YJD3;H7BZ44 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 55055400.0 15099900.0 15698500.0 24257000.0 False True 19796115.127639618 13356344.992273737 21747118.329574257 1.0 0.6746952574359106 1.0985548522705155 24.238714001789333 -6.701665347936723 1.8247666418255026 0.7983254116619504 1.0973388456716529 0.42546459473608134 0.1372746392577078 0.3921196518009185 2.5395115376248576 0.059987177500939376 0.15396422372455795 1.9876259220873625e-07 6.701665347936723 0.2990134340097025 LHNFHQLSAPQPCFTFSHPNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHNFHQLSAPQPCFTFSHPNR 21 0 O14744-2;O14744;O14744-3;O14744-5;O14744-4;H0YJD3;H7BZ44 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 47381900.0 15099900.0 14227800.0 18054200.0 False True 20682741.089454148 13599168.750957157 13790169.797920624 1.0 0.6575128843967007 0.6667476877594356 24.301924063312224 -10.690425864808288 6.682520785049354 1.002884122289412 0.6621302860780688 0.9994400157757076 0.0037700926856064384 0.00016305900164392248 7.553857420616479e-06 0.0036742996969145267 0.0012167921820843484 2.0397368182442673e-11 10.690425864808288 -0.34075383621134325 LHNFHQLSAPQPCFTFSHPNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHNFHQLSAPQPCFTFSHPNR 21 0 O14744-2;O14744;O14744-3;O14744-5;O14744-4;H0YJD3;H7BZ44 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 23384500.0 4421200.0 11687000.0 7276300.0 False True 5723330.5548811145 11036608.17630133 5952088.0611427715 1.0 1.9283541410846545 1.039969298307707 22.448423502458812 -6.635845203026986 2.059106909862353 1.6089801364421814 1.0436023463165822 0.13898865810708372 0.3976269432478219 0.5439347258215448 4.4022953474464686 0.15752385821250034 0.4404208931072815 2.3128890337183065e-07 6.635845203026986 -0.5653777901255992 LHNTIVEINNHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHNTIVEINNHK 12 0 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 5944300.0 1834200.0 0.0 4110100.0 False True 2404653.962418065 0.0 3684826.278863137 1.0 0.0 1.5323727806381588 21.197397869713722 -6.730613020289145 1.7210247050068879 0.3986149617783511 1.5315584923477092 0.5620943020360865 0.4203560251286356 0.33508938491205054 1.9447042882355716 0.1935357558715979 0.4799074472892028 1.8594605963962255e-07 6.730613020289145 1.1329435305693583 LHNTIVEINNHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHNTIVEINNHK 12 0 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 5589500.0 1834200.0 0.0 3755300.0 False True 2512353.3073912244 0.0 2868375.4828312136 1.0 0.0 1.1417086420100981 21.260607931236613 -10.692940910155654 4.436513966247783 1.0186351385780994 0.5708543210133322 0.15851919602572628 0.46610060130864756 0.08650189603941262 0.005986947499561519 0.4543964908079114 0.15043332221044226 2.027958623574065e-11 10.692940910155654 -0.4477808175647672 LHNVLFSILQCHPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHNVLFSILQCHPK 14 0 Q14146 Q14146 URB2 Unhealthy ribosome biogenesis protein 2 homolog 0 11948000.0 4154700.0 2796600.0 4996700.0 False True 5446851.934172038 2379358.1810614183 4479689.415730865 1.0 0.4368318085046493 0.8224364219681713 22.37699121918307 -10.107512440921768 5.897822474647812 1.0000020178914113 0.6296341152364102 0.5515758478280419 0.15742242424151776 4.177009486780533e-06 6.319663685551339e-07 0.1524244380294277 0.050807868950574854 7.807060754919542e-11 10.107512440921768 -0.3703679026550011 LHNVLFSILQCHPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHNVLFSILQCHPK 14 0 Q14146 Q14146 URB2 Unhealthy ribosome biogenesis protein 2 homolog 0 13685900.0 4154700.0 2821600.0 6709600.0 False True 5690804.866545818 2696932.38221656 5124930.668549606 1.0 0.4739105355853703 0.9005634156738036 22.44020128070596 -9.990194181756248 7.020228154019931 1.0000000254769927 0.6872369756295887 0.4174213989435277 0.17418030891758782 6.94288593064208e-08 9.844334118730915e-09 0.16864937274063335 0.05621645297292323 1.0228355597716115e-10 9.990194181756248 -0.312763049847404 LHPVILASIVDSYER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHPVILASIVDSYER 15 0 O00303;E9PQV8;A0A1W2PP79 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 5049260.0 357060.0 1705100.0 2987100.0 False True 489074.7311836826 1629763.0439883228 2281608.501255591 1.0 3.3323394975730816 4.6651531060161915 18.899695401926394 -8.593059930285264 0.26912560292994425 9.227453077318769e-16 5.540318260963991 0.9990861337779311 0.04579049288435073 0.21288170476029822 0.07706980158161089 0.6662924004167424 0.4860169910912911 2.5523490680171682e-09 8.593059930285264 5.54031826096399 LHQEYVPSAHLSGTCTCLAWAPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHQEYVPSAHLSGTCTCLAWAPAR 24 0 Q15061 Q15061 WDR43 WD repeat-containing protein 43 0 27866000.0 7619200.0 9106800.0 11140000.0 False True 9988844.984437749 7748100.938028367 9987339.662425568 1.0 0.7756753608750183 0.9998492996923543 23.25188643737593 -10.91799820157577 9.349209797595552 1.0192081979744414 0.8877623302836223 0.250504184441695 0.09151862728872802 0.03668934364581006 0.00032180131947556176 0.08872830622679063 0.029537509946417278 1.2078188367042082e-11 10.91799820157577 -0.13144586769081912 LHQEYVPSAHLSGTCTCLAWAPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHQEYVPSAHLSGTCTCLAWAPAR 24 0 Q15061 Q15061 WDR43 WD repeat-containing protein 43 0 25025100.0 7619200.0 7613900.0 9792000.0 False True 10436224.141137945 7277492.722199689 7479331.272570311 1.0 0.697330051921074 0.7166702412118546 23.31509649889882 -10.271937253112204 5.526595303912568 1.0000277433720004 0.7070001465664558 0.9967428985915232 0.007895599215241971 2.6992610430939944e-06 3.555937451744812e-07 0.007645603982444115 0.002548293689075208 5.3464159886117405e-11 10.271937253112204 -0.2930275968055446 LHQLAMQQSHFPMTHGNTGFSGIESSSPEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHQLAMQQSHFPMTHGNTGFSGIESSSPEVK 31 0 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;F8VRH0;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 27430100.0 9193900.0 12171000.0 6065200.0 False True 12053291.933854261 10355134.242186422 5437631.285506609 1.0 0.8591125394633312 0.4511324636744135 23.522923886022873 -6.952242596897311 0.5336546814404356 1.006270279733621 0.2853377793944859 0.9993657337717898 0.0058617199151284214 0.08259751355994918 0.032330598604837356 0.006504930192827059 0.03375441556493789 1.1162395421882608e-07 6.952242596897311 -0.720932500339135 down LHQLAMQQSHFPMTHGNTGFSGIESSSPEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHQLAMQQSHFPMTHGNTGFSGIESSSPEVK 31 0 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;F8VRH0;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 26199900.0 5095500.0 3258400.0 17846000.0 False True 4933746.141635681 4559496.112331526 13171597.231475867 1.0 0.9241448549316565 2.6696949647087234 22.234252055204347 -6.896741840833993 0.9816497387459268 0.9207971964603292 2.8412560712811716 0.9848740052581316 0.09907605893773419 0.11384297886026697 0.1912599086370479 0.07613730242089932 0.1950456836259252 1.2684056245338912e-07 6.896741840833993 1.9204588748208424 up LHQLAMQQSHFPMTHGNTGFSGIESSSPEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHQLAMQQSHFPMTHGNTGFSGIESSSPEVK 31 0 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;F8VRH0;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 44128000.0 9193900.0 18038000.0 16896100.0 False True 12593133.285805376 17241021.516310718 12905589.166102441 1.0 1.3690811591539582 1.0248116075011495 23.586133947545765 -10.878139922465698 14.909733576879846 0.9969977510620566 1.19694638332755 0.3037920994426325 0.14054745592101975 0.014090560405725597 0.00011516448978662692 0.13670827439762245 0.04536149634449421 1.3239149230850508e-11 10.878139922465698 0.19994863226549342 LHQLAMQQSHFPMTHGNTGFSGIESSSPEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHQLAMQQSHFPMTHGNTGFSGIESSSPEVK 31 0 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;F8VRH0;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 11949500.0 5095500.0 4247900.0 2606100.0 False True 4237134.018924377 4225015.719557871 3151023.46075505 1.0 0.9971399773260932 0.743668585105306 22.014657330638624 -6.909365170562115 0.9000478846763321 1.008006409461479 0.7113526835551442 0.9906797722269082 0.01160111364953911 0.10483928820725154 0.14105571483092552 0.00946827532503914 0.026023157757622754 1.2320684297163e-07 6.909365170562115 -0.29665372590633465 LHQLLALTLWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHQLLALTLWK 11 0 Q7L5D6;Q7L5D6-2;C9JPA8;C9JY46;C9JHN8 Q7L5D6 GET4 Golgi to ER traffic protein 4 homolog 0 8616760.0 3591600.0 2901220.0 2123940.0 False True 3477586.623942446 4059692.2756624343 1567616.3971657974 1.0 1.167387822265106 0.4507770953491399 21.729655020935887 -6.845181192313008 1.258206249155339 1.089077850788055 0.4246980967992769 0.9329826225851098 0.07923856044071977 0.16283841963546833 0.49851424670456124 0.049336395262008385 0.11386437230851097 1.4282979329782092e-07 6.845181192313008 -0.6643797539887781 down LHQLLALTLWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHQLLALTLWK 11 0 Q7L5D6;Q7L5D6-2;C9JPA8;C9JY46;C9JHN8 Q7L5D6 GET4 Golgi to ER traffic protein 4 homolog 0 55632900.0 12636400.0 18252500.0 24744000.0 False True 19170342.64458408 14995198.767566597 19853337.554319516 1.0 0.7822081767434124 1.0356276839907395 24.192372787718615 -6.679322241415343 1.905072570677957 0.8621107971671889 1.0346402347888937 0.32072246219331035 0.09231996002087187 0.4400060428570396 3.087105210600141 0.038900360440685434 0.1026570392910575 2.0925592252637924e-07 6.679322241415343 0.1725294376217048 LHQLLALTLWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHQLLALTLWK 11 0 Q7L5D6;Q7L5D6-2;C9JPA8;C9JY46;C9JHN8 Q7L5D6 GET4 Golgi to ER traffic protein 4 homolog 0 8982500.0 3591600.0 2439800.0 2951100.0 False True 2986574.534857975 2426656.313137619 3568161.3656552834 1.0 0.8125215978421972 1.1947337406146354 21.510060296370163 -6.773362698407276 1.5619142328244686 0.892928017350519 1.1971447421391512 0.74313108377747 0.07908802152632372 0.2610313605914484 1.25724820147816 0.03990383898322464 0.09468481865115295 1.6851450988327414e-07 6.773362698407276 0.30421672478863226 LHQLLALTLWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHQLLALTLWK 11 0 Q7L5D6;Q7L5D6-2;C9JPA8;C9JY46;C9JHN8 Q7L5D6 GET4 Golgi to ER traffic protein 4 homolog 0 46472200.0 12636400.0 16952300.0 16883500.0 False True 16358068.900683023 16008889.602730645 13810876.239339229 1.0 0.9786540024942798 0.8442852468216809 23.963499109811064 -6.934831670991819 0.7060371974328654 1.0017238253309562 0.8129712030313269 0.9974050474877042 0.003511155204610243 0.09020611342054734 0.06595869287411353 0.0032963019093062928 0.011851798806699872 1.161898869126637e-07 6.934831670991819 -0.1887526222996293 LHQMWLSWNQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHQMWLSWNQK 11 0 O60664-4;O60664-3;O60664;K7ERZ3;O60664-2 O60664-4 PLIN3 Perilipin-3 0 44239000.0 12865000.0 13576000.0 17798000.0 False True 16866139.58483724 11550513.718833532 15956433.690471295 1.0 0.6848344673500457 0.9460631824022271 24.007626463614123 -10.012240936157768 6.524652469722546 1.0000000662722828 0.8154488258092156 0.3995700256273661 0.10664617634013022 1.0281256281287102e-07 1.5564597973128427e-08 0.10325975392330813 0.03441990540850116 9.722077166246976e-11 10.012240936157768 -0.18455124046306715 LHQMWLSWNQK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LHQMWLSWNQK 11 0 O60664-4;O60664-3;O60664;K7ERZ3;O60664-2 O60664-4 PLIN3 Perilipin-3 0 36682300.0 14217200.0 8177100.0 14288000.0 False True 13765882.76810184 11442258.673013156 10545544.169187896 1.0 0.831204134581695 0.7660637786066231 23.71459379316621 -13.999999999999998 0.13181334586201116 1.8024531177076928 0.676905733957158 0.999637482658177 0.0018769359847171736 11.9343624302668 0.11307884089270276 2.4772784533692502 0.07934841281088231 1.0000000000000041e-14 13.999999999999998 -1.1255473837505348 LHQMWLSWNQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHQMWLSWNQK 11 0 O60664-4;O60664-3;O60664;K7ERZ3;O60664-2 O60664-4 PLIN3 Perilipin-3 0 47457000.0 13019000.0 12023000.0 22415000.0 False True 19750774.81639074 9877401.713872254 17984665.425156474 1.0 0.5001019861598144 0.9105802477293897 24.23540591506271 -10.00965546236214 7.09886839466028 1.0000000274785623 0.7053411169446028 0.40725442313548077 0.16757704855835817 7.294712482264513e-08 1.0217684695806363e-08 0.16225579407504256 0.05408525985609266 9.780127974546011e-11 10.00965546236214 -0.29465891053395954 LHQMWLSWNQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHQMWLSWNQK 11 0 O60664-4;O60664-3;O60664;K7ERZ3;O60664-2 O60664-4 PLIN3 Perilipin-3 0 38944000.0 12865000.0 10713000.0 15366000.0 False True 17621538.16355259 10239664.236846471 11736867.272703765 1.0 0.5810879925354997 0.6660523708979985 24.070836525137015 -9.892802577384712 5.43443775639365 1.0000003619833042 0.6235701817144957 0.9631970891631169 0.03468656222476356 1.5211846568394488e-07 3.1034384291833676e-08 0.03358515198399849 0.011195039818323796 1.27996302055315e-10 9.892802577384712 -0.3764301802688085 LHQMWLSWNQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHQMWLSWNQK 11 0 O60664-4;O60664-3;O60664;K7ERZ3;O60664-2 O60664-4 PLIN3 Perilipin-3 0 28055500.0 11784000.0 7970000.0 8301500.0 False True 9798918.119714439 7927064.028078861 10037305.26820078 1.0 0.8089733918819471 1.0243279049354161 23.224191042074118 -6.672645166689254 1.9278691341030287 0.8783465101393338 1.023470206712918 0.29083325062852616 0.0810949148276615 0.4550961557070406 3.263389289329642 0.033832981344501904 0.09008680298732856 2.1249799335592965e-07 6.672645166689254 0.14512369657358415 LHQMWLSWNQK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LHQMWLSWNQK 11 0 O60664-4;O60664-3;O60664;K7ERZ3;O60664-2 O60664-4 PLIN3 Perilipin-3 0 78655200.0 18399800.0 35215400.0 25040000.0 False True 23818903.814281516 33255632.03317551 20482976.9320967 1.0 1.3961865034794696 0.8599462465529318 24.505603683707008 -6.708777478668893 1.799540380923642 1.2438688175279513 0.8612492970072898 0.4593150794426679 0.16698283227321142 0.3775323551144327 2.3824420414214633 0.07386406114494151 0.1879296986368744 1.955341065663444e-07 6.708777478668893 -0.3826195205206615 LHSLLGDYYQAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHSLLGDYYQAIK 13 0 B0QY89;Q9Y262;Q9Y262-2;B0QY90 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 10916100.0 2459900.0 3137700.0 5318500.0 False True 3224952.7217054875 2669567.3906588033 4768192.638654439 1.0 0.8277849695877174 1.4785310204897586 21.62084657988766 -6.836360727037648 1.2994108917611489 0.9083038367728915 1.4984084497150336 0.9179709891507875 0.07884841965084415 0.17309864483278847 0.569341170753423 0.047610523345671514 0.10958838612841285 1.4576030653767468e-07 6.836360727037648 0.5901046129421421 LHSLLGDYYQAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHSLLGDYYQAIK 13 0 B0QY89;Q9Y262;Q9Y262-2;B0QY90 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 8695070.0 2941700.0 849670.0 4903700.0 False True 2848317.34370517 1188947.661970515 3619273.862153327 1.0 0.41742106601924456 1.27067086473071 21.44167846165528 -6.722906388877848 1.7489957586029026 0.6466690096491214 1.2695509533370066 0.5261455712409042 0.2450677735162889 0.34969537660611344 2.0921115470476415 0.11119368937595604 0.2781735144620847 1.8927515526849326e-07 6.722906388877848 0.6228819436878852 LHSLLGDYYQAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHSLLGDYYQAIK 13 0 B0QY89;Q9Y262;Q9Y262-2;B0QY90 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 7960100.0 2459900.0 1640900.0 3859300.0 False True 3369391.5062979395 1568399.6122693333 2947812.824778449 1.0 0.4654845272025349 0.8748798764609302 21.684056641410553 -9.83138187344992 6.364994813549289 1.0000000120233574 0.6701822018316541 0.4639129059534355 0.16713495145889282 2.8452241822164672e-08 5.303994294192186e-09 0.161827728126496 0.05394257363074602 1.474409520569647e-10 9.83138187344992 -0.3298178101917033 LHSLLGDYYQAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHSLLGDYYQAIK 13 0 B0QY89;Q9Y262;Q9Y262-2;B0QY90 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 5443550.0 2941700.0 954550.0 1547300.0 False True 2446153.889406309 949407.6496866602 1870833.276093123 1.0 0.3881226172230256 0.764806042741318 21.222083737089555 -10.088527125911574 5.206749263919628 1.0000076046507955 0.5764643299815803 0.6276497434559505 0.15378036451622354 1.3575711490173135e-05 2.376174498330811e-06 0.14889987002302918 0.04963239922842096 8.155918439039567e-11 10.088527125911574 -0.42354327466921526 LHTLEEEKEELAQYQK(ub)WDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHTLEEEKEELAQYQKWDK 19 2 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 8286400.0 4311800.0 2671500.0 1303100.0 True False 5652811.555530603 2272922.61342544 1168267.7122178413 1.0 0.4020871014533743 0.20667020309120873 22.430537172839177 -13.999999999999998 0.15635804525086705 3.9231154361497014 0.0066315407432196855 0.9995464248319865 0.007187499606220892 11.987376815997235 0.12482579998218837 10.631165252321937 0.18152039928589223 1.0000000000000041e-14 13.999999999999998 -3.916483895406482 LHTLEEEKEELAQYQK(ub)WDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHTLEEEKEELAQYQKWDK 19 2 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 12489400.0 4933700.0 4419400.0 3136300.0 True False 4777082.394070843 6184089.466866542 2314808.9430167964 1.0 1.2945327203361678 0.4845654213312001 22.187698329636028 -6.808316531780242 1.421605110118227 1.1608414347050584 0.470936326344606 0.8553778285390234 0.12729974579986383 0.2091101824968571 0.833227872372652 0.07041721713205948 0.1630167507375696 1.5548319926717865e-07 6.808316531780242 -0.6899051083604524 down LHTLEEEKEELAQYQK(ub)WDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHTLEEEKEELAQYQKWDK 19 2 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 22826000.0 11283000.0 5475800.0 6067200.0 True False 17117135.89779067 4498600.707379328 4868015.2606517775 1.0 0.26281270033966186 0.28439426372025817 24.028937989097347 -10.778884030625191 10.767955036976712 1.0030213910131893 0.2736034821036212 0.9993384048325363 0.008810636355665948 0.0006381477863003688 1.3104106172506246e-05 0.008518527887604243 0.002843620656248655 1.6638568896849283e-11 10.778884030625191 -0.7294179089095681 LHTLEEEKEELAQYQK(ub)WDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHTLEEEKEELAQYQKWDK 19 2 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 25634700.0 11283000.0 7228400.0 7123300.0 True False 14606065.921180591 6826133.185725733 5826932.491230207 1.0 0.46734919741988845 0.39893921625948836 23.800064311189796 -13.999999999999998 0.2893477597510948 5.573012465451306 0.3801744579625559 0.999626002664869 0.005195883774056952 15.927005995730326 0.1705672552335026 43.33796749673244 0.025912973972474235 1.0000000000000041e-14 13.999999999999998 -5.19283800748875 LHTLIPCK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHTLIPCKK 9 1 Q8IWA4 Q8IWA4 MFN1 Mitofusin-1 1 15266300.0 1452000.0 7102200.0 6712100.0 True False 2202790.155418955 5834756.920258127 5385450.492982059 1.0 2.648802885696753 2.4448313788463363 21.070900635331636 -9.939243144639173 7.0095726474175 0.999999943259125 2.546817132271549 0.9871265438777098 0.08327101897503696 7.385630034700215e-08 1.1140930698352828e-08 0.08062681983080017 0.026875605809334287 1.1501562807552856e-10 9.939243144639173 1.5468171890124243 LHTLIPCK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHTLIPCKK 9 1 Q8IWA4 Q8IWA4 MFN1 Mitofusin-1 1 14233200.0 1452000.0 6896700.0 5884500.0 True False 1879642.6231989926 6512892.5823134575 4813581.380068804 1.0 3.4649632339306424 2.5609024399949476 20.842026957424086 -10.234121528726606 5.933827874897428 0.9999425568570273 3.0129328369628077 0.868594106337722 0.36908127359969567 0.0002804840583762532 3.6201926296422996e-05 0.35737137525418156 0.11912046883738031 5.832818615347344e-11 10.234121528726606 2.0129902801057806 LHTYLAGEAPTLADLAAVTALLLPFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHTYLAGEAPTLADLAAVTALLLPFR 26 0 P26640;A0A140T936;A0A140T954;A2ABF4;A0A0G2JJT9;A0A140T904 P26640 VARS Valine--tRNA ligase 0 6013000000.0 2630400000.0 1997800000.0 1384800000.0 False True 3990509107.9986334 1641276981.117357 1111093673.0205984 1.0 0.4112951347053833 0.2784340651656468 31.893925670792292 -13.999999999999998 0.20916708975012815 4.39308818305797 0.1995441930533386 0.9994895609828309 0.0070842426710640985 12.727319462990586 0.1449658745382447 17.740470211285125 0.07916210853602068 1.0000000000000041e-14 13.999999999999998 -4.193543990004631 LHTYLAGEAPTLADLAAVTALLLPFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHTYLAGEAPTLADLAAVTALLLPFR 26 0 P26640;A0A140T936;A0A140T954;A2ABF4;A0A0G2JJT9;A0A140T904 P26640 VARS Valine--tRNA ligase 0 3752237000.0 2630400000.0 45737000.0 1076100000.0 False True 3405104652.9356937 43191695.743945725 880260841.7184197 1.0 0.012684395972002865 0.2585121255992844 31.66505199288474 -10.775893281165134 7.546173583272542 1.0176022194257421 0.13559826078568935 0.9428105183574219 0.10035875036895041 0.027729780504473247 0.000823519523658959 0.09066422166008381 0.03239064740209435 1.6753545089696145e-11 10.775893281165134 -0.8820039586400528 LHVEVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHVEVAK 7 0 O43719;Q5H918;Q5H919 O43719 HTATSF1 HIV Tat-specific factor 1 0 4786800.0 1648100.0 1754000.0 1384700.0 False True 2160675.0602231016 1492310.037038451 1241424.5269803135 1.0 0.6906684232678475 0.5745540131574108 21.043050693695083 -13.999999999999998 0.13597745598417652 2.4732313380086723 0.42364627873647437 0.9996194462865287 0.0035027935312284073 11.932065789761388 0.11522220459434195 4.676020358387 0.13457833367610492 1.0000000000000041e-14 13.999999999999998 -2.049585059272198 LHVEVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHVEVAK 7 0 O43719;Q5H918;Q5H919 O43719 HTATSF1 HIV Tat-specific factor 1 0 2664840.0 894110.0 614730.0 1156000.0 False True 865726.9674610697 860194.8947746003 853208.9207433662 1.0 0.9936099106364985 0.9855404218787185 19.72355257468003 -6.967967034792804 0.3029884167348579 1.001350741036174 0.9775457207922689 0.9999608538499456 3.656378842312935e-05 0.0769696769840868 0.011387494336002241 0.0001319305925123942 0.0007214512180722168 1.0765469260325971e-07 6.967967034792804 -0.023805020243905073 LHVEVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHVEVAK 7 0 O43719;Q5H918;Q5H919 O43719 HTATSF1 HIV Tat-specific factor 1 0 5182700.0 1648100.0 1365800.0 2168800.0 False True 2257447.1082278253 1305454.4399033801 1656574.1078380805 1.0 0.5782879408980738 0.733826321688905 21.106260755217974 -10.29282933437559 6.201182604300541 1.00001416418738 0.6560571312934892 0.8670182524592325 0.06349827805937508 1.2435107631368692e-05 1.4180353474447317e-06 0.06148447313081819 0.02049398111973384 5.095310632231218e-11 10.29282933437559 -0.3439570328938909 LHVGNISPTCTNK(ub)ELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHVGNISPTCTNKELR 16 1 Q9BWF3;E9PB51;D6R9K7;J3QRR5;Q9BWF3-3;Q9BWF3-4;Q9BWF3-2 Q9BWF3 RBM4 RNA-binding protein 4 1 6320500.0 1021800.0 2186200.0 3112500.0 True False 1339589.6951252748 1860027.4817408554 2790448.3572082245 1.0 1.3885053673594516 2.0830619758890196 20.353359752505295 -6.962177916158073 0.4035676766920679 0.9632897803330661 2.533785331163001 0.9998426408419784 0.005619888626879225 0.07893210260848345 0.018322692012025507 0.008935168485894412 0.058116957173164875 1.0909933008326679e-07 6.962177916158073 1.5704955508299347 up LHVIFGGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHVIFGGTK 9 0 Q9HD20-2;Q9HD20 Q9HD20-2 ATP13A1 Manganese-transporting ATPase 13A1 0 19117100.0 4759400.0 7093400.0 7264300.0 False True 6239619.490095168 6035092.369856637 6512659.920086012 1.0 0.9672212190882473 1.0437591475608843 22.573026621409944 -6.790339766226591 1.4950847072073394 0.9816880568635791 1.044579563610043 0.8023910500978247 0.013937632740408714 0.23484516338709915 1.037055962786617 0.0073377668020991665 0.01717445203895474 1.6205417855863148e-07 6.790339766226591 0.06289150674646393 LHVNMGTTLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHVNMGTTLHR 11 0 Q69YN4-2;Q69YN4-3;Q69YN4;Q69YN4-4;H0YBN5 Q69YN4-2 KIAA1429 Protein virilizer homolog 0 8195500.0 2593600.0 2992400.0 2609500.0 False True 3552524.0094045857 2860185.8734564874 1993189.8443394832 1.0 0.8051137348782799 0.5610630185926733 21.76041296914603 -6.968083017318051 0.30046723136020287 1.042092226017132 0.3164323050281183 0.9999633306706807 0.0010873719120133053 0.07692975593541124 0.011244707503082494 0.00403952140658819 0.021877002458383327 1.0762594621915923e-07 6.968083017318051 -0.7256599209890136 LHVNMGTTLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHVNMGTTLHR 11 0 Q69YN4-2;Q69YN4-3;Q69YN4;Q69YN4-4;H0YBN5 Q69YN4-2 KIAA1429 Protein virilizer homolog 0 8828100.0 1964400.0 3449200.0 3414500.0 False True 2542954.5241130134 3257248.987909519 2793096.0357286003 1.0 1.2808915602002962 1.0983664903338517 21.27807423173628 -10.30677127239702 4.174460564380742 0.9997578698744523 1.1896290252725172 0.5900195823620469 0.07451554775796417 0.00016813161546609778 2.7920716948461984e-05 0.0722410986413113 0.02404978962249581 4.934336096317049e-11 10.30677127239702 0.18987115539806498 LHVTALDYLAPYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHVTALDYLAPYAK 14 0 Q9Y221;Q9Y221-2;J3QLW7;J3QRD6;J3QRR4 Q9Y221 NIP7 60S ribosome subunit biogenesis protein NIP7 homolog 0 7073900.0 2584300.0 1772200.0 2717400.0 False True 2502262.8110742997 2479848.701900908 2005631.419747424 1.0 0.9910424640152931 0.801527086152211 21.254801892129912 -6.916758688588129 0.8484153195952678 1.004689658039078 0.7731334677341636 0.9932322305719757 0.007529254360300419 0.1001167250417262 0.11577282168596363 0.006378244176804484 0.018552065608461742 1.2112709772818875e-07 6.916758688588129 -0.23155619030491448 LHVTALDYLAPYAK(ub)YK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHVTALDYLAPYAKYK 16 1 Q9Y221;J3QRD6;J3QRR4 Q9Y221 NIP7 60S ribosome subunit biogenesis protein NIP7 homolog 1 30671500.0 9585300.0 5115200.0 15971000.0 True False 14541600.879295643 4202352.594759982 12814324.849662015 1.0 0.28898830532086045 0.8812183029935221 23.793682767959126 -10.396047255213395 8.326698110090724 1.0000038815733527 0.5851033041574351 0.39554828169769973 0.2417768841112817 1.7422386327262078e-05 1.2635347000194535e-06 0.23410165081113563 0.07803315380507621 4.017470947107633e-11 10.396047255213395 -0.4149005774159177 LHVTALDYLAPYAK(ub)YK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHVTALDYLAPYAKYK 16 1 Q9Y221;J3QRD6;J3QRR4 Q9Y221 NIP7 60S ribosome subunit biogenesis protein NIP7 homolog 1 7166600.0 1865200.0 3245800.0 2055600.0 True False 2554814.8451347263 3102389.823574745 1570109.6164109 1.0 1.2143305920907717 0.6145688480716892 21.284787307968383 -6.81004828056453 1.4141284781457253 1.11679983245928 0.6040430402229598 0.860020958342496 0.09284253931944626 0.20672143389245703 0.8147226922027663 0.051621640541767266 0.11942008137766544 1.5486444463718217e-07 6.81004828056453 -0.5127567922363202 LHYAFQTEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHYAFQTEGK 10 0 E9PGT3;Q15418;Q15418-4;Q15418-2;Q15418-3;E9PMM7;A0A2R8Y7S9;E9PAN7;F2Z2J1;B7Z3B5;Q15349-2;D6R910;Q9UK32-2;Q9UK32;Q15349-3;Q15349;D6RE03;D6RA62;D6RHW7;B4DG22;B1AXG1;B7ZB17;P51812 E9PGT3;B4DG22 RPS6KA1;RPS6KA2;RPS6KA6;RPS6KA3 Ribosomal protein S6 kinase;Ribosomal protein S6 kinase alpha-1;Ribosomal protein S6 kinase alpha-2;Ribosomal protein S6 kinase alpha-6;Ribosomal protein S6 kinase alpha-3 0 3938270.0 499470.0 1163600.0 2275200.0 False True 654810.006874361 989995.415677276 2039784.1292594846 1.0 1.5118819280158426 3.115077820811098 19.320716843832418 -6.950478895281142 0.5535597771755797 0.9782818888611253 3.7244551788799125 0.9992383404141141 0.02486528871416995 0.0832939836360336 0.03517072338935945 0.026866419253603464 0.1330905062128143 1.1207818896699061e-07 6.950478895281142 2.7461732900187874 LHYCVSCAIHSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LHYCVSCAIHSK 12 0 P62854;Q5JNZ5 P62854 RPS26;RPS26P11 40S ribosomal protein S26;Putative 40S ribosomal protein S26-like 1 0 315680300.0 126370000.0 96770300.0 92540000.0 False True 165672293.76882064 82332548.44767492 82964848.50636108 1.0 0.49696027365059525 0.5007768445708269 27.303757112506364 -10.038557268150988 5.174888491687991 1.0000052756712563 0.4988685591092384 0.9999564997544066 0.0015581085594790149 9.534682142659078e-08 1.771137912907841e-08 0.001508648100485013 0.0005028773743603601 9.150455890302296e-11 10.038557268150988 -0.501136716562018 LHYCVSCAIHSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LHYCVSCAIHSK 12 0 P62854;Q5JNZ5 P62854 RPS26;RPS26P11 40S ribosomal protein S26;Putative 40S ribosomal protein S26-like 1 0 30418600.0 23127000.0 2722200.0 4569400.0 False True 22392846.044079747 3809188.6560854632 3372537.060938354 1.0 0.17010739271761938 0.15060779028711227 24.416534565012242 LHYCVSCAIHSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LHYCVSCAIHSK 12 0 P62854;Q5JNZ5 P62854 RPS26;RPS26P11 40S ribosomal protein S26;Putative 40S ribosomal protein S26-like 1 0 208605000.0 58557000.0 68176000.0 81872000.0 False True 88835250.09012921 56009460.1384807 65689963.31422768 1.0 0.630486885348501 0.7394583034052461 26.404628920056652 -10.424703846390146 8.741150269395808 1.0000029484801511 0.6849725943768741 0.9176494313912069 0.04448739513108914 2.5562767465099593e-06 1.681948026712817e-07 0.043075138376408695 0.014358245038238094 3.760937823175519e-11 10.424703846390146 -0.31503035410327707 LHYCVSCAIHSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LHYCVSCAIHSK 12 0 P62854;Q5JNZ5 P62854 RPS26;RPS26P11 40S ribosomal protein S26;Putative 40S ribosomal protein S26-like 1 0 242427550.0 126370000.0 58764550.0 57293000.0 False True 173092404.0208423 56168137.87261974 43761573.38637365 1.0 0.32449799394926915 0.25282203245096907 27.366967174029256 -13.999999999999998 0.3168849464150133 7.799481649561774 0.23809228838069812 0.9996870162759742 0.005954960565464774 17.77471960528479 0.1793856429345977 79.99120366924285 0.02415803498895125 1.0000000000000041e-14 13.999999999999998 -7.561389361181076 LHYCVSCAIHSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LHYCVSCAIHSK 12 0 P62854;Q5JNZ5 P62854 RPS26;RPS26P11 40S ribosomal protein S26;Putative 40S ribosomal protein S26-like 1 0 47948500.0 23127000.0 1083500.0 23738000.0 False True 19231125.199816313 1077662.9704420876 28701506.047888912 1.0 0.05603743718814649 1.4924506886452518 24.196939840446518 -6.729454934302658 1.7254647016301747 0.4315799324685028 1.4914760105985108 0.5566567936999739 0.3968353145854733 0.33724551470936864 1.9668393864265146 0.18228487181942374 0.4525642546449444 1.864425635194003e-07 6.729454934302658 1.059896078130008 LHYCVSCAIHSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LHYCVSCAIHSK 12 0 P62854;Q5JNZ5 P62854 RPS26;RPS26P11 40S ribosomal protein S26;Putative 40S ribosomal protein S26-like 1 0 225671000.0 58557000.0 88997000.0 78117000.0 False True 75803190.83103532 84044238.71534964 63900507.54810699 1.0 1.108716371883125 0.8429791259122679 26.1757552421491 -6.795625282840197 1.4736863877380704 1.0603213009066395 0.8396946051433246 0.8190522087519041 0.0464015033838022 0.22707304791539593 0.9739783404385186 0.024775790055798733 0.05778018229575845 1.6009387518786267e-07 6.795625282840197 -0.22062669576331484 LIADVAPSAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIADVAPSAIR 11 0 P39748;F5H1Y3 P39748 FEN1 Flap endonuclease 1 0 5416300.0 1616100.0 791500.0 3008700.0 False True 1564797.790108414 1107550.077617972 2220631.2109347438 1.0 0.7077911821061796 1.4191170418133654 20.57754480727688 -6.79515552284986 1.4755651375743564 0.8377705705996771 1.4278053653440803 0.8176204517722623 0.12467313067172243 0.22775423211557336 0.9794204373430284 0.06648511714465434 0.15510137675996974 1.6026713639345335e-07 6.79515552284986 0.5900347947444032 LIAHAGSLLNLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIAHAGSLLNLAK 13 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 14006500.0 5885600.0 6538400.0 1582500.0 False True 7716078.596231473 5562896.206483585 1418758.080411891 1.0 0.7209486187971827 0.183870351075067 22.87943640812538 -7.203916305906585 0.5014039854276494 1.0105551067228529 2.2543042883381737e-13 0.9990779728636212 0.010284246916379225 0.08816427625999802 0.03837454391730462 0.011524002007176421 0.048782093900249984 6.252931831478514e-08 7.203916305906585 -1.0105551067226275 down LIAHAGSLLNLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIAHAGSLLNLAK 13 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 15024600.0 8134700.0 2652700.0 4237200.0 False True 7876468.40120966 3711936.9436477497 3127350.2067247326 1.0 0.4712691976365543 0.3970498004212697 22.909117477923814 -13.999999999999998 0.27660392385826343 5.22956046097266 0.37394853477648976 0.9995976889497498 0.005384588794923756 15.217611366218678 0.1665586146506414 36.33662972660763 0.02984072604770909 1.0000000000000041e-14 13.999999999999998 -4.85561192619617 LIAHAGSLLNLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIAHAGSLLNLAK 13 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 13564700.0 2323900.0 6086300.0 5154500.0 False True 3525526.199847177 5000152.212521054 4135710.815702397 1.0 1.4182711825366092 1.1730761824665124 21.74940717130492 -10.251328960944477 4.661456556439337 0.9999042994312243 1.2956736825026876 0.6597291128108724 0.1001004396127711 9.958969360527757e-05 1.5994957034603645e-05 0.09695310006618282 0.03230727796347855 5.606231652234994e-11 10.251328960944477 0.2957693830714633 LIAHAGSLLNLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIAHAGSLLNLAK 13 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 19670000.0 5885600.0 6431500.0 7352900.0 False True 8061665.3723595 6147335.063873613 5616296.457728981 1.0 0.7625391007856237 0.6966670282526494 22.94264646964827 -13.999999999999998 0.17990706884939292 2.231725535422033 0.6442911896581015 0.9994982487990043 0.00291806680175878 12.203530935585627 0.1344590887156054 5.254244459959537 0.04922129257230867 1.0000000000000041e-14 13.999999999999998 -1.5874343457639313 LIAHAGSLLNLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIAHAGSLLNLAK 13 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 12418700.0 8134700.0 2935900.0 1348100.0 False True 6764363.478313055 2920083.7239694744 1629981.4770898588 1.0 0.4316864008463522 0.24096598036395808 22.68952275335809 -13.99999999999905 0.1525116260997408 3.759206653149624 0.03707616818117674 0.9995580737383037 0.006777545374001728 11.968051539161419 0.12311579179033239 9.779604485994142 0.18423785606685505 1.0000000000021883e-14 13.99999999999905 -3.722130484968447 LIAHAGSLLNLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIAHAGSLLNLAK 13 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 13654000.0 2323900.0 5755500.0 5574600.0 False True 3008334.3609174457 5435201.365508886 4560080.000226285 1.0 1.806714518213103 1.5158155487861418 21.52053349339737 -10.148539574697354 4.475865604014667 0.9999179124880907 1.661265033336904 0.8732537861215621 0.11875900759775684 18173763.99572796 20603539.821606148 15009.940975434472 0.04065436339976452 7.103304388259588e-11 10.148539574697354 0.6613471208488132 LIAHAGSLTNLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIAHAGSLTNLAK 13 0 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 0 8320600.0 1862200.0 3519200.0 2939200.0 False True 2441362.2335704537 2994149.0777341565 2635079.778797238 1.0 1.2264255736254512 1.0793481371027336 21.219254938103365 -10.292469544669508 4.145757255596928 0.9998217139974046 1.152886855369864 0.5902889212136075 0.060044112045785254 9.906065902348484e-05 1.6906082911428205e-05 0.05820508950662685 0.01937915382989335 5.0995335730504325e-11 10.292469544669508 0.1530651413724593 LIAHAGSLTNLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIAHAGSLTNLAK 13 0 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 0 5519030.0 1469700.0 925130.0 3124200.0 False True 1423045.1779731074 1294539.2334892154 2305878.2960090167 1.0 0.9096965110644432 1.6203830571938405 20.440550033720637 -6.8750127403156815 1.1073029975400515 0.947005016914603 1.6661572283397916 0.9694319203242572 0.05523017670767262 0.13213619032575527 0.2998018657720835 0.03858085753164166 0.09222007238930652 1.333482313004492e-07 6.8750127403156815 0.7191522114251886 LIAHAGSLTNLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIAHAGSLTNLAK 13 0 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 0 7373500.0 1862200.0 0.0 5511300.0 False True 2550705.664062776 0.0 4209644.448786425 1.0 0.0 1.6503842478168507 21.282464999626256 -6.742698861203093 1.6769842596007298 0.4068554829126227 1.6518960660101667 0.6168900092515538 0.42014127079321295 0.3129728812293442 1.7292390820423924 0.19812230595893318 0.4847097041078411 1.808427650947294e-07 6.742698861203093 1.245040583097544 LIAHAGSLTNLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIAHAGSLTNLAK 13 0 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 0 3503220.0 1469700.0 1071800.0 961720.0 False True 1222120.6687495168 1066026.0006643578 1162811.2055091306 1.0 0.8722755681361021 0.951470043215068 20.220955309154913 -10.267498481839095 4.863192595427029 1.0000241442270583 0.9118728056762895 0.6227956301644118 0.03233100906550883 8.465931125690636e-06 1.275170866066463e-06 0.03131293929468905 0.010434788306351599 5.401340029048894e-11 10.267498481839095 -0.08815133855076884 LIALLEVLSQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIALLEVLSQK 11 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98;O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;O75369-5;O75369-4 P21333-2;O75369-2 FLNA;FLNB Filamin-A;Filamin-B 0 48021000.0 11486000.0 22510000.0 14025000.0 False True 17425101.739078578 18492914.628567252 11252952.602624135 1.0 1.0612801523616895 0.6457897790856273 24.054663743721914 -6.869405281937337 1.13729905591334 1.0345332107845782 0.6217365126752004 0.964082821998056 0.034707805173095345 0.1374231029216172 0.3325943674438175 0.023693481220968333 0.056035591938279825 1.3508114028338556e-07 6.869405281937337 -0.4127966981093778 LIALLEVLSQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIALLEVLSQK 11 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98;O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;O75369-5;O75369-4 P21333-2;O75369-2 FLNA;FLNB Filamin-A;Filamin-B 0 31407700.0 11486000.0 12056000.0 7865700.0 False True 14868853.422908822 11385073.001924265 6434223.308897478 1.0 0.7656994576584495 0.43273163880841714 23.825790065814363 -6.966139520681903 0.33792540261055065 1.036994176031011 0.1504061830727415 0.9999347430348983 0.001880196095986412 0.07757638250488254 0.013508139579471532 0.004730724323154278 0.02886405005958471 1.0810865875272898e-07 6.966139520681903 -0.8865879929582696 down LIALSIDSVEDHLAWSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIALSIDSVEDHLAWSK 17 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 98284000.0 66128000.0 12113000.0 20043000.0 False True 64028802.836637065 16949784.068460513 14793137.022888659 1.0 0.2647212397787001 0.23103878828769972 25.93221769997853 -13.397308603273537 0.44562394420435464 9.99999999992166 0.23092860048607017 0.9998850544959742 0.003804107190476268 19.790179940637813 0.22594762572907703 171.64968425658014 0.007682942862841264 4.005819688127241e-14 13.397308603273537 -9.76907139943559 LIALSIDSVEDHLAWSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIALSIDSVEDHLAWSK 17 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 406653000.0 193430000.0 129450000.0 83773000.0 False True 293447451.6271959 106348636.10253368 67215229.83098976 1.0 0.36241117621850083 0.22905371799371402 28.128526938535405 -13.999999999999972 0.2199228293633019 4.8461837291218695 0.15766775449625212 0.9994978150590591 0.007539203914837283 12.997515266682987 0.14856389537614947 21.70961236950139 0.07384082435843438 1.0000000000000655e-14 13.999999999999972 -4.688515974625617 LIALSIDSVEDHLAWSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIALSIDSVEDHLAWSK 17 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 13188200.0 3138700.0 3145800.0 6903700.0 False True 4299162.2101781955 3006808.1542305234 5273188.246164584 1.0 0.699393976601291 1.2265618249249581 22.035624114491807 -6.752001655071916 1.6421685212480301 0.8236727020506647 1.2277902000425052 0.6576812334446451 0.1263315816032834 0.2965495744940927 1.5739767325216505 0.06075268999114741 0.14719802764877715 1.7701022125443007e-07 6.752001655071916 0.4041174979918405 LIALSIDSVEDHLAWSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIALSIDSVEDHLAWSK 17 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 97718000.0 66128000.0 16144000.0 15446000.0 False True 54988361.96711433 16057029.067666901 18675687.185765147 1.0 0.29200777206765627 0.3396298147039568 25.712622975412806 -9.964366391476851 7.19502231824822 1.0000000241971498 0.3158187933858061 0.9963795723371869 0.019441617494668956 7.530299695264765e-09 1.1110941941647123e-09 0.01882426561579803 0.006274755065015331 1.085509449816637e-10 9.964366391476851 -0.6841812308113437 LIALSIDSVEDHLAWSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIALSIDSVEDHLAWSK 17 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 391273000.0 193430000.0 126680000.0 71163000.0 False True 250398948.07533133 119630146.63933027 58212064.19404147 1.0 0.4777581837258362 0.23247727133633422 27.899653260627854 -9.833947137421168 0.1947190628092453 1.5921621733695808 1.984325000675655e-09 0.9994792099272217 0.0073042083538032085 1.3052093987196698 0.08517666324141979 0.5686323497003566 0.14828154107794908 1.465726239155064e-10 9.833947137421168 -1.5921621713852558 LIANMPESGPSYEFHLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIANMPESGPSYEFHLTR 18 0 Q96HE7 Q96HE7 ERO1L ERO1-like protein alpha 0 9709100.0 2926000.0 4024300.0 2758800.0 False True 3836014.3354243026 3423890.1265985393 2473345.8402782446 1.0 0.8925644763576781 0.6447697073073287 21.871176681131445 -6.957164633208477 0.4737088349063877 1.0063145277243404 0.5207976531541031 0.9996501422728353 0.002782245074962906 0.08073000037228241 0.024995278791901544 0.0034504995671272966 0.02044694037853816 1.103660162921742e-07 6.957164633208477 -0.4855168745702373 LIANMPESGPSYEFHLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIANMPESGPSYEFHLTR 18 0 Q96HE7 Q96HE7 ERO1L ERO1-like protein alpha 0 7686500.0 2926000.0 2169400.0 2591100.0 False True 4007821.2721768185 2073548.7347535435 1979135.5453795886 1.0 0.517375549939958 0.4938183144840278 21.934386742654336 LIANNTTVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIANNTTVER 10 0 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 0 6404450.0 681550.0 3080700.0 2642200.0 False True 893518.6501395891 2621071.568474545 2368810.4897720697 1.0 2.9334268155063925 2.651103577303064 19.769138316947103 -10.242554924755481 5.083643168310033 0.9997471739677635 2.792265196405565 0.9817298558562715 0.11525797935764177 0.0003303139661196444 4.921527644286437e-05 0.11161280312823241 0.03719935288038781 5.7206460168304184e-11 10.242554924755481 1.7925180224378017 LIANNTTVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIANNTTVER 10 0 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 0 6185080.0 1737200.0 953980.0 3493900.0 False True 1682053.5368952053 1334909.1889399774 2578742.7752467524 1.0 0.7936187283337014 1.5330919728076482 20.681792194170523 -6.83223227401066 1.3180128507890754 0.8898858070104035 1.553898208642382 0.9102472043951911 0.09333817138371373 0.17807271417189408 0.604212843097885 0.05559130874742105 0.1279224015835919 1.4715252750794967e-07 6.83223227401066 0.6640124016319785 LIANNTTVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIANNTTVER 10 0 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 0 6410450.0 681550.0 2546100.0 3182800.0 False True 933537.4531962116 2433604.88317323 2431088.1918236073 1.0 2.606863682695474 2.604167817263395 19.832348378469995 -10.099817274293526 4.735234745926681 0.9999122996062783 2.605515750001198 0.9999978853444598 0.0011005825286948127 383043.334173528 0.06871846497666018 366.3051459599359 0.0003767586621137134 7.946625118847909e-11 10.099817274293526 1.60560345039492 LIAPVAEEEATVPNNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIAPVAEEEATVPNNK 16 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 106464000.0 2761000.0 61563000.0 42140000.0 False True 3619697.7375620315 52378040.37069448 37779757.03542309 1.0 14.470280163772063 10.437268461224837 21.787437799581028 -9.577399168935012 7.224508225120486 0.9999946855070095 12.453774312503645 0.9149238310990996 1.6464701330073075 0.0 0.0 1.5941878512816359 0.5313959504272118 2.646066966356168e-10 9.577399168935012 11.453779626996635 LIAPVAEEEATVPNNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIAPVAEEEATVPNNK 16 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 72928000.0 19914000.0 11273000.0 41741000.0 False True 19281840.970372494 15774367.687918404 30807779.896841545 1.0 0.8180944813390227 1.597761331201685 24.200739466403448 -6.845242640615725 1.257773143125873 0.9031899864598008 1.6261929012911522 0.9331026414095563 0.0861412739812829 0.1627659654528633 0.4978982223615973 0.05364979532718213 0.12383300834941094 1.428095857477214e-07 6.845242640615725 0.7230029148313515 LIAPVAEEEATVPNNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIAPVAEEEATVPNNK 16 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 107430000.0 2761000.0 53511000.0 51158000.0 False True 3781816.313219481 51146707.0827865 39075534.03208251 1.0 13.524376343716447 10.332478046459453 21.85064786110392 -9.568916869396999 9.328925410986272 1.0000182734569034 11.928427195087954 0.9398673179216864 1.303087023232402 0.0 0.0 1.26170862249138 0.4205695282967399 2.6982558704387744e-10 9.568916869396999 10.92840892163105 LIAPVAEEEATVPNNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIAPVAEEEATVPNNK 16 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 22363980.0 19914000.0 929580.0 1520400.0 False True 16559373.339782184 924572.1680328161 1838308.6104646712 1.0 0.055833765509207225 0.11101317500030781 23.981144741837724 -10.242992030525263 4.383006344333519 1.0004385704941883 0.08342347024409492 0.9972891902468949 0.022526899684084264 256454155.85713387 408993021.3867158 1454430.584664182 0.00824393957688702 5.714891236260765e-11 10.242992030525263 -0.9170151002500934 LIAQACVSIFPDSGHFNVDNIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIAQACVSIFPDSGHFNVDNIR 22 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 846269500.0 238360500.0 332930000.0 274979000.0 False True 361610304.9867346 273516040.3060371 220629280.12242287 1.0 0.7563834230776991 0.6101299578022713 28.429860550628053 -11.506736033008426 0.06935748042747385 2.0840619362327826 1.4187569083638103e-14 0.9999634446079599 0.0009722551197085547 4.51150733224252 0.04789248178957408 1.1745434828800736 0.4198769062516727 3.113608233292019e-12 11.506736033008426 -2.0840619362327684 LIAQACVSIFPDSGHFNVDNIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIAQACVSIFPDSGHFNVDNIR 22 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 553272900.0 238360500.0 149110000.0 165802400.0 False True 308562366.03789425 140811897.42177576 135628064.47628853 1.0 0.45634825539444684 0.4395483033716178 28.200986872720502 LIASVAGSVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIASVAGSVER 11 0 Q13868;Q13868-3;A3KFL2;Q13868-2;A3KFL5;A3KFL1 Q13868 EXOSC2 Exosome complex component RRP4 0 6634600.0 1537600.0 3139300.0 1957700.0 False True 2015808.4901395836 2670928.6768955593 1755135.9835844277 1.0 1.3249912826344987 0.8706858772397046 20.94292715287935 -6.714678102322871 1.77855868836371 1.1988384302773896 0.8716014309263918 0.48724000603112494 0.13685438070382633 0.36576702732458766 2.2581752012190552 0.061168969288051545 0.15452108365023598 1.9289541180702916e-07 6.714678102322871 -0.3272369993509978 LIASVAGSVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIASVAGSVER 11 0 Q13868;Q13868-3;A3KFL2;Q13868-2;A3KFL5;A3KFL1 Q13868 EXOSC2 Exosome complex component RRP4 0 14643700.0 2142400.0 9064500.0 3436800.0 False True 3250177.4304198083 7446869.153738254 2757514.9735970455 1.0 2.2912192682281907 0.8484198271110608 21.63208704777283 -6.670735477730843 1.9345047693498358 1.8236382906833044 0.8541963137769286 0.2824462873342508 0.5483851571533446 0.45941469420878206 3.3152203446178556 0.2281428957702722 0.6090146092291469 2.1343445146231662e-07 6.670735477730843 -0.9694419769063758 LIASVAGSVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIASVAGSVER 11 0 Q13868;Q13868-3;A3KFL2;Q13868-2;A3KFL5;A3KFL1 Q13868 EXOSC2 Exosome complex component RRP4 0 4872400.0 1537600.0 1661000.0 1673800.0 False True 2106092.272077611 1587611.5278075205 1278482.9129930746 1.0 0.753818599904637 0.6070403134483187 21.00613721440224 -11.759675008852252 0.06906307234953712 2.128163638076204 3.210290302567243e-12 0.9999606175351974 0.0010174188687329885 5.129249640303271 0.05013140529456194 1.3098536819439037 0.4340279590452462 1.7391017461600068e-12 11.759675008852252 -2.128163638072994 LIASVAGSVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIASVAGSVER 11 0 Q13868;Q13868-3;A3KFL2;Q13868-2;A3KFL5;A3KFL1 Q13868 EXOSC2 Exosome complex component RRP4 0 2709220.0 1083700.0 1140700.0 484820.0 False True 901144.5660501135 1134554.8226887777 586193.6204455938 1.0 1.2590153294290451 0.6504989793313529 19.781399043287163 -6.791024095016741 1.4920320525791753 1.1445675196883627 0.6438230387989451 0.8047121043723355 0.1101866279745127 0.23381282278140314 1.028217411149863 0.0581230434890163 0.13599159961964538 1.617990267715732e-07 6.791024095016741 -0.5007444808894176 LIASYCNVGDIEGASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIASYCNVGDIEGASK 16 0 P42704;B8ZZ38;A0A0C4DG06;C9JCA9 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 23428500.0 3774700.0 11808000.0 7845800.0 False True 5726495.867534373 9700770.143674908 6295074.191063696 1.0 1.6940150430688632 1.0992890480813589 22.449221170618237 -10.315830469981117 4.3387115504295055 0.9995734249463062 1.3966520455794185 0.37229105803390383 0.24279587076259246 172618476.54176918 494.3224477441507 735629.9008968784 0.08311548455139962 4.8324740437547586e-11 10.315830469981117 0.3970786206331123 LIAVDISPVESTGVSHFATYVAAMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIAVDISPVESTGVSHFATYVAAMR 25 0 Q8NFV4;Q8NFV4-4 Q8NFV4 ABHD11 Alpha/beta hydrolase domain-containing protein 11 0 54414000.0 12878000.0 22448000.0 19088000.0 False True 19536867.50790995 18441979.012975466 15315248.433432389 1.0 0.9439578277074769 0.7839152529048814 24.219695831974047 -6.952553648332845 0.5300763448820268 1.0025227330316007 0.7180842031949745 0.9993866965846159 0.002267440647266612 0.08247640024182534 0.03184295794204949 0.0025293830822178567 0.013234777226964315 1.1154403526588103e-07 6.952553648332845 -0.2844385298366262 LIAVDISPVESTGVSHFATYVAAMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIAVDISPVESTGVSHFATYVAAMR 25 0 Q8NFV4;Q8NFV4-4 Q8NFV4 ABHD11 Alpha/beta hydrolase domain-containing protein 11 0 36709000.0 12878000.0 12081000.0 11750000.0 False True 16670824.863330977 11408681.729947511 9611620.565181144 1.0 0.6843501640426901 0.5765533885682401 23.990822154066496 -13.999999999999998 0.1499591312731114 2.526202284189981 0.45789979571724976 0.9995663755998222 0.003741575300536835 11.957545589991566 0.12195613453508194 5.317774419971433 0.10694315077553143 1.0000000000000041e-14 13.999999999999998 -2.0683024884727312 LICCDILDVLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LICCDILDVLDK 12 0 P62258;P62258-2;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 0 22800400.0 3188600.0 15556000.0 4055800.0 False True 4180285.478446321 13235105.436813071 3636144.7219807585 1.0 3.1660769354278977 0.8698316755467613 21.995170038968904 -6.659363735963456 1.9754381203826936 2.395017056304567 0.8794682784035592 0.2328331365020755 0.9224083136742841 0.48592127054652073 3.6446660915447295 0.3773634287477536 1.0222800401996537 2.1909691577081483e-07 6.659363735963456 -1.5155487779010077 LICCDILDVLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LICCDILDVLDK 12 0 P62258;P62258-2;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 0 44914600.0 3188600.0 23463000.0 18263000.0 False True 4367511.588674986 22426327.078234725 13949655.538291622 1.0 5.134806542102025 3.193959593481849 22.058380100491796 -9.184427554185904 10.94964542566547 1.0000000000049745 4.164383067920875 0.7799456026338237 0.7923474488263307 0.0 0.0 0.7671871184285153 0.2557290394761717 6.539920150482538e-10 9.184427554185904 3.1643830679159004 LICCDILDVLDK(ub)HLIPAANTGESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LICCDILDVLDKHLIPAANTGESK 24 1 P62258;P62258-2 P62258 YWHAE 14-3-3 protein epsilon 1 123955000.0 33870000.0 60195000.0 29890000.0 True False 51383266.228677675 49452731.94431837 23982228.39874759 1.0 0.9624287355387725 0.4667322682839261 25.614795263717404 -6.9220717109827445 0.8092142159780713 1.0101421999809104 0.3828596637439636 0.9947372715543712 0.01762934881103529 0.09696818622484688 0.09941028914076695 0.0153585336203676 0.04695806918907349 1.196542941058517e-07 6.9220717109827445 -0.6272825362369467 down LICCDILDVLDK(ub)HLIPAANTGESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LICCDILDVLDKHLIPAANTGESK 24 1 P62258;P62258-2 P62258 YWHAE 14-3-3 protein epsilon 1 91069000.0 33870000.0 37500000.0 19699000.0 True False 43845382.677513674 35413092.03485071 16113984.128808822 1.0 0.8076812168641988 0.3675183826613734 25.385921585809854 -6.957324881534926 0.47162605191867324 1.0114440918346697 0.14566150907036016 0.9996577528172638 0.0048975787903188 0.08067093892546418 0.024769934869689546 0.006104716818792191 0.036324999947873554 1.1032530035491641e-07 6.957324881534926 -0.8657825827643095 down LIDDMVAQVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIDDMVAQVLK 11 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 6116300.0 1378700.0 2447100.0 2290500.0 False True 1807489.0513497905 2082002.2187210878 2053501.0320274509 1.0 1.1518754247315066 1.1361070378235179 20.785555477573208 -10.075361531264726 4.401238575635715 0.9999879386059318 1.143991231289852 0.9910859435522329 0.006437417042831887 4470067.362210885 0.13381119333914518 555.7629587727453 0.0022036990724392793 8.406950082455157e-11 10.075361531264726 0.1440032926839201 LIDDMVAQVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIDDMVAQVLK 11 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 6150400.0 2668600.0 0.0 3481800.0 False True 2583886.753717789 0.0 2569812.128238971 1.0 0.0 0.9945529247910857 21.301111410474437 -11.99957804639401 17.78819332488997 0.8708556850006615 0.5475488161560036 0.0 0.4845391119308874 0.0 0.0 0.0 0.13873069895380835 1.0009720562237985e-12 11.99957804639401 -0.32330686884465787 LIDDMVAQVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIDDMVAQVLK 11 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 11066200.0 1378700.0 5094300.0 4593200.0 False True 1888442.6479665688 4869216.981402678 3508380.7599234027 1.0 2.5784298965317998 1.8578169496972257 20.8487655390961 -10.123202894493605 4.820027181396022 0.9999386612119191 2.2181234231108453 0.7920968449763297 0.29418900372918527 102625708.61296375 12.325906325508633 82418.11287684765 0.10070872092990642 7.530036918984352e-11 10.123202894493605 1.218184761898926 LIDDMVAQVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIDDMVAQVLK 11 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 3918000.0 2668600.0 0.0 1249400.0 False True 2219059.1390249445 0.0 1510643.7634270971 1.0 0.0 0.6807586768917184 21.081516685908714 -10.437941617436705 8.094753716180033 1.000018602446879 0.3403793415796919 0.5559141919175747 0.27791856605948534 9.330539741729458e-05 6.478168534071219e-06 0.2691010526265512 0.08969783149585271 3.6480298439376696e-11 10.437941617436705 -0.659639260867187 LIDFLECGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIDFLECGK 9 0 J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 9964600.0 1524200.0 3578000.0 4862400.0 False True 1998240.9603737956 3044176.3469347632 4359285.491434299 1.0 1.5234280586287814 2.181561472255499 20.930299132121995 -6.9680235615648725 0.30168513059215596 0.8881195078818382 2.837541599597854 0.9999626007073578 0.002956312327844379 0.0769493902920907 0.011313548605496458 0.010828408510300253 0.05892050720549725 1.0764068142763446e-07 6.9680235615648725 1.9494220917160157 LIDFLECGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIDFLECGK 9 0 J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 11226700.0 1524200.0 5192300.0 4510200.0 False True 2087737.9299562238 4962887.017360027 3444983.6504847426 1.0 2.3771599615781707 1.6501034929019935 20.993509193644886 -10.217299258532423 5.5974471829580965 0.9999578557070872 2.0136317272401225 0.7215701855787406 0.2968195604079031 0.00015611894986464583 2.1830377262197633e-05 0.2874061658341326 0.09579810119067786 6.063183908670217e-11 10.217299258532423 1.0136738715330353 LIDFLECGK(ub)TNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIDFLECGKTNLR 13 1 J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 22689700.0 2972900.0 4090800.0 15626000.0 True False 3848477.654620027 3863143.3838977967 12782228.336299628 1.0 1.003810787171952 3.3213726266423285 21.875856439945977 -6.907255359119446 0.9141997547049773 0.921867002392296 3.603961907559002 0.9898444788707337 0.1101878047591921 0.10626180812236849 0.14881055179597324 0.08900541562817604 0.24127169178949753 1.2380684054556904e-07 6.907255359119446 2.6820949051667062 up LIDFLESGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIDFLESGK 9 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 6731840.0 988540.0 2303400.0 3439900.0 False True 1295985.513034977 1959741.6985828774 3083972.1458507865 1.0 1.5121632756476548 2.379634737296291 20.30561816070303 -6.9631604568471985 0.3883361841631585 0.9457254185528124 2.9771585751221217 0.9998700527606215 0.006491130949691318 0.07859092319546299 0.017096675934594224 0.011211228687080934 0.07302222336955784 1.0885278454965895e-07 6.9631604568471985 2.0314331565693093 LIDFLESGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIDFLESGK 9 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 5258500.0 2568800.0 1024100.0 1665600.0 False True 2487254.8500900287 1433028.4706109487 1229329.3930710624 1.0 0.5761486285006455 0.4942514809154219 21.246122906442398 -13.999999999999998 0.23114058518610672 3.6898491486497864 0.4548620684326676 0.9995113722580898 0.004899443631166156 13.327057415018809 0.1522183505022799 16.462432912995606 0.04221232276641301 1.0000000000000041e-14 13.999999999999998 -3.234987080217119 LIDFLESGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIDFLESGK 9 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 8054840.0 988540.0 3309000.0 3757300.0 False True 1354029.9522890206 3162797.438600294 2869903.124022509 1.0 2.3358400848175536 2.119527060070472 20.368828222225922 -10.185931982013976 4.4955942258381825 0.999731241581238 2.2276835724625825 0.9772460069190997 0.08830942263271567 30996996.230542433 43.435167011728744 86236.19300276016 0.03023066424900351 6.51730458268097e-11 10.185931982013976 1.2279523308813445 LIDHLENTK(ub)GFNLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIDHLENTKGFNLR 14 1 Q9H0S4;Q9H0S4-2;F5H1N9 Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 1 8102800.0 1922500.0 2293100.0 3887200.0 True False 2633300.203609002 2191783.2597323465 2969123.4193969877 1.0 0.8323332283681345 1.1275294078995368 21.32844057136504 -6.752634442814206 1.640017242620823 0.9017204549466392 1.1282377112589457 0.6601990873473151 0.07046629446321942 0.29550353384873584 1.564533311705541 0.03392993985332494 0.08214869296338788 1.7675249673644953e-07 6.752634442814206 0.22651725631230646 LIDIQEK(ub)IQALQTACPDLQLSAASVGNCPTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIDIQEKIQALQTACPDLQLSAASVGNCPTK 31 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 50893000.0 22827000.0 17767000.0 10299000.0 True False 34630227.87723718 14596340.035795385 8263398.135787947 1.0 0.4214913077539902 0.2386180698862674 25.045528545141952 -13.999999999999998 0.16118541078643675 3.856328541453523 0.061175433166084425 0.9995332998613546 0.00701067597702112 12.017792244453496 0.1269123840724064 10.730877946559579 0.16196702736219243 1.0000000000000041e-14 13.999999999999998 -3.7951531082874386 LIDLAYTPFHAVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIDLAYTPFHAVLK 14 0 B4DVT3;B4DJL6;Q96SY0-4;Q96SY0-3;Q96SY0;H3BRY6 B4DVT3 VWA9 von Willebrand factor A domain-containing protein 9 0 7849400.0 3313500.0 3395300.0 1140600.0 False True 4344030.5879796455 2888734.474775742 1022581.6534077737 1.0 0.6649894415497788 0.23539927555698076 22.05060283106939 -7.32612469126624 0.38211127726772154 1.038271930598244 9.484562380106228e-11 0.99952793405514 0.006799312191319772 0.10551388013731106 0.031896811075374246 0.012743396787591012 0.05362274372104945 4.719275256362899e-08 7.32612469126624 -1.0382719305033983 down LIDLAYTPFHAVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIDLAYTPFHAVLK 14 0 B4DVT3;B4DJL6;Q96SY0-4;Q96SY0-3;Q96SY0;H3BRY6 B4DVT3 VWA9 von Willebrand factor A domain-containing protein 9 0 8918700.0 3711200.0 2710800.0 2496700.0 False True 3593389.9874081714 3793236.5766352452 1842739.370605503 1.0 1.0556150570707241 0.5128136319917305 21.776914087566464 -6.881639937025965 1.0706485910344992 1.0352736753352954 0.4731210037267515 0.9749827676306179 0.03856616943211351 0.12618561810505524 0.2636124560889645 0.02770658844424987 0.06728752200899685 1.313288263091492e-07 6.881639937025965 -0.5621526716085439 LIDLAYTPFHAVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIDLAYTPFHAVLK 14 0 B4DVT3;B4DJL6;Q96SY0-4;Q96SY0-3;Q96SY0;H3BRY6 B4DVT3 VWA9 von Willebrand factor A domain-containing protein 9 0 15544800.0 4043300.0 6156700.0 5344800.0 False True 6133981.704824692 5057988.782483348 4288397.93729094 1.0 0.8245849149672194 0.699121409820622 22.548392432962356 -6.9747492708970285 0.08895115625314523 1.3744009441071319 0.14614273186943685 0.9999998417577199 4.874586946626366e-05 0.07478957769600436 0.002593205789273891 0.013191796089287828 0.022435065287007293 1.0598654354955493e-07 6.9747492708970285 -1.228258212237695 LIDLAYTPFHAVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIDLAYTPFHAVLK 14 0 B4DVT3;B4DJL6;Q96SY0-4;Q96SY0-3;Q96SY0;H3BRY6 B4DVT3 VWA9 von Willebrand factor A domain-containing protein 9 0 13962500.0 3313500.0 4434200.0 6214800.0 False True 4538590.493970576 4238282.382061477 4746992.237823724 1.0 0.9338322961042527 1.0459177236038382 22.113812892592282 -6.746769001174562 1.662045221028861 0.9609416558035878 1.0460835000205266 0.6348559376317131 0.027800681937469544 0.3057123533336377 1.660551786032406 0.013219951780015239 0.03220105872295447 1.791558520691283e-07 6.746769001174562 0.08514184421693882 LIDLAYTPFHAVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIDLAYTPFHAVLK 14 0 B4DVT3;B4DJL6;Q96SY0-4;Q96SY0-3;Q96SY0;H3BRY6 B4DVT3 VWA9 von Willebrand factor A domain-containing protein 9 0 7680700.0 3711200.0 1981900.0 1987600.0 False True 3086027.2340363353 1971223.1113236498 2403197.970375941 1.0 0.6387575228055944 0.778735178961044 21.55731936300074 -10.213358385871658 4.875590037311078 1.0000425528603185 0.7087463508827633 0.852344069334066 0.05714563883052311 2.643653408270026e-05 4.265278869895337e-06 0.05533909818271468 0.018443675624642726 6.118452800709298e-11 10.213358385871658 -0.29129620197755524 LIDLAYTPFHAVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIDLAYTPFHAVLK 14 0 B4DVT3;B4DJL6;Q96SY0-4;Q96SY0-3;Q96SY0;H3BRY6 B4DVT3 VWA9 von Willebrand factor A domain-containing protein 9 0 6877000.0 4043300.0 0.0 2833700.0 False True 5234131.555358456 0.0 2317995.676217348 1.0 0.0 0.44286156198047666 22.319518755054805 -10.382172589784927 5.604383331155595 1.0002683833629091 0.22143078099023814 0.8047236878506697 0.1807974755906999 0.0006064876504862857 6.685925356825018e-05 0.17511462357089597 0.058352134333258164 4.1478917155383555e-11 10.382172589784927 -0.778837602372671 LIDLHSPSEIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIDLHSPSEIVK 12 0 P60866;P60866-2;G3XAN0 P60866 RPS20 40S ribosomal protein S20 0 26324600.0 2130600.0 11719000.0 12475000.0 False True 2793237.232759749 9970570.880304223 11184206.668649824 1.0 3.5695395877467915 4.0040303549869645 21.413506677847725 -9.910829722971455 0.43880044416648084 9.459155266735293e-14 4.026054943888742 0.9989005370891108 0.04395524375577994 1.21741508340001 0.19557346474569365 1.7596311873425903 0.09989343002491152 1.2279205766326714e-10 9.910829722971455 4.026054943888647 LIDLHSPSEIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIDLHSPSEIVK 12 0 P60866;P60866-2;G3XAN0 P60866 RPS20 40S ribosomal protein S20 0 27942500.0 11243000.0 4589500.0 12110000.0 False True 10886097.119107062 6422111.283926316 8938027.707787333 1.0 0.589936982341849 0.8210497857950839 23.37598347628826 -10.151076778823189 5.3541953396533035 1.0000083906247905 0.7054933840683623 0.6840556467339869 0.0943514069144593 9.45045118546555e-06 1.498377013188547e-06 0.09135795877916844 0.030451785639192226 7.061926955795551e-11 10.151076778823189 -0.29451500655642826 LIDLHSPSEIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIDLHSPSEIVK 12 0 P60866;P60866-2;G3XAN0 P60866 RPS20 40S ribosomal protein S20 0 26462600.0 2130600.0 13222000.0 11110000.0 False True 2918340.397300047 12637808.320692986 8486046.817632368 1.0 4.330477805942403 2.9078331045560626 21.476716739370616 -10.41727216562649 15.513877334078098 0.9999999980389845 3.619155455248346 0.8188166524916902 0.5807922672784464 4.826405648497612e-08 1.0802797171868488e-09 0.5623496988836951 0.1874498982312891 3.825849081368092e-11 10.41727216562649 2.619155457209361 LIDLHSPSEIVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIDLHSPSEIVK 12 0 P60866;P60866-2;G3XAN0 P60866 RPS20 40S ribosomal protein S20 0 13484300.0 11243000.0 1123900.0 1117400.0 False True 9349052.649350766 1117845.3276233177 1351043.1737261394 1.0 0.11956776472971785 0.1445112381327707 23.156388751722535 -10.261944366983576 4.841560608248286 1.0002317746401685 0.1320395014301079 0.9993809775220678 0.010183130379032042 57615951.136914395 58.671662782451605 148902.81901699206 0.0034858658814465784 5.470860399927485e-11 10.261944366983576 -0.8681922732100606 LIDLHTNVATAVLEHIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIDLHTNVATAVLEHIK 17 0 Q8WVM8;Q8WVM8-2;Q8WVM8-3 Q8WVM8 SCFD1 Sec1 family domain-containing protein 1 0 5816100.0 2460800.0 1514900.0 1840400.0 False True 2382683.2509738198 2119807.470099136 1358344.029183469 1.0 0.8896723763986486 0.5700900565059599 21.184155744678456 -6.952235962735238 0.533732634166493 1.004909023438902 0.4402526604975972 0.9993652705682461 0.004593047811785668 0.08260013261963596 0.032341288613187455 0.0050964752279612615 0.026441066192419132 1.1162565936842037e-07 6.952235962735238 -0.5646563629413048 LIDLHTNVATAVLEHIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIDLHTNVATAVLEHIK 17 0 Q8WVM8;Q8WVM8-2;Q8WVM8-3 Q8WVM8 SCFD1 Sec1 family domain-containing protein 1 0 25115700.0 5968500.0 10852000.0 8295200.0 False True 9054650.855797533 8915375.812937 6655650.084084683 1.0 0.9846183972106051 0.7350531997402404 23.110227581750777 -6.919496891823599 0.8284613517828339 1.0056070050786359 0.6952721684333075 0.9940397720419409 0.009375016673990717 0.09846862908598474 0.1071587335207447 0.008056083297657538 0.024016527876573827 1.2036580041489187e-07 6.919496891823599 -0.31033483664532835 LIDLHTNVATAVLEHIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIDLHTNVATAVLEHIK 17 0 Q8WVM8;Q8WVM8-2;Q8WVM8-3 Q8WVM8 SCFD1 Sec1 family domain-containing protein 1 0 6771900.0 2460800.0 2226200.0 2084900.0 False True 2046264.231924074 2214207.0187338977 2520842.9505115706 1.0 1.0820728741624484 1.2319244558857665 20.964561020112733 -6.961787191205045 0.40947466793177695 0.9925757765364186 1.3269778810369532 0.9998308304075648 0.0012488866860370376 0.07906885503272737 0.018817691868585742 0.0019293420660767232 0.012513608986641769 1.091975284574119e-07 6.961787191205045 0.33440210450053465 LIDLHTNVATAVLEHIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIDLHTNVATAVLEHIK 17 0 Q8WVM8;Q8WVM8-2;Q8WVM8-3 Q8WVM8 SCFD1 Sec1 family domain-containing protein 1 0 16020000.0 5968500.0 5155500.0 4896000.0 False True 7726340.906723948 4868591.892951271 4004978.237202295 1.0 0.6301290548433237 0.5183538088148442 22.881353903843227 -13.999999999999998 0.16766449034893463 2.8541414922440653 0.41726319377809923 0.9995183299437633 0.004517269005370869 12.069660746119773 0.1296163402838379 7.2771612529713465 0.09310387053163155 1.0000000000000041e-14 13.999999999999998 -2.4368782984659663 LIDQFQMMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIDQFQMMR 9 0 Q8IZD9 Q8IZD9 DOCK3 Dedicator of cytokinesis protein 3 0 33226900.0 13536000.0 11814000.0 7876900.0 False True 20535101.614153538 9705699.3967967 6320027.262432082 1.0 0.4726394628652424 0.30776703135844674 24.291588750455833 -13.999999999999998 0.1627800130089152 3.6130180730295693 0.15056001669136373 0.999529333670752 0.006405096354910911 12.029364506006496 0.12758773133872725 9.922811161804235 0.14379670396899719 1.0000000000000041e-14 13.999999999999998 -3.4624580563382055 LIDQFQMMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIDQFQMMR 9 0 Q8IZD9 Q8IZD9 DOCK3 Dedicator of cytokinesis protein 3 0 33138000.0 13536000.0 12885000.0 6717000.0 False True 17522618.834450092 12167938.423174689 5494574.922240149 1.0 0.6944132345818131 0.31357041856309853 24.062715072548283 -7.125658548322176 0.32470558955052975 1.0549332254124484 2.6924048871200173e-11 0.9999254076282631 0.0024251277123729016 0.07916987012853181 0.014963490648560446 0.007295221441010534 0.03544710431957535 7.487579587894984e-08 7.125658548322176 -1.0549332253855244 down LIEEVMIGEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIEEVMIGEDK 11 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 10612300.0 2149700.0 3602400.0 4860200.0 False True 2818277.51772441 3064935.962045221 4357313.126330412 1.0 1.0875209920845457 1.5460908654051502 21.426382251139074 -6.938767172505326 0.67093765748421 0.994726583584647 1.6653918981385636 0.9979978912001506 0.010715570985813404 0.08833361858115771 0.05720544000247793 0.010335827707933443 0.039687380321383345 1.1514175043278702e-07 6.938767172505326 0.6706653145539165 LIEEVMIGEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIEEVMIGEDK 11 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 12564500.0 2149700.0 4058700.0 6356100.0 False True 2944502.1834581364 3879373.2136739264 4854920.087988569 1.0 1.31749714279982 1.6488084523295428 21.489592312661966 -6.970588930469622 0.2437097392098383 0.886376429597004 2.0895561584781306 0.9999866181569362 0.0009690003685726502 0.07611207999672435 0.008343473662440794 0.00771591900903056 0.032090151509974574 1.0700672428343633e-07 6.970588930469622 1.2031797288811266 LIEK(ub)LDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIEKLDIK 8 1 P13639 P13639 EEF2 Elongation factor 2 1 9767100.0 1842900.0 4691600.0 3232600.0 True False 2416059.7466689884 3991631.567713561 2898121.561288772 1.0 1.652124527639189 1.1995239626356096 21.204224700790675 -10.254723940307535 4.230513369457028 0.9997005460471642 1.425824245152412 0.5413343233261367 0.18477340697601902 130588587.81711014 195.7982103537041 380929.1439485771 0.0632528518850203 5.562577306609427e-11 10.254723940307535 0.4261236991052477 LIEK(ub)LDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIEKLDIK 8 1 P13639 P13639 EEF2 Elongation factor 2 1 40789800.0 8111800.0 15663000.0 17015000.0 True False 12306193.652016163 12867815.274422418 13651977.792060556 1.0 1.0456373138833424 1.1093582774738726 23.552881264496378 -6.966421309286101 0.33276345328995083 0.9924826957944024 1.1646075181636293 0.9999394948374073 0.0003488052880553651 0.07748197834322335 0.013177437642734838 0.0009208565162830404 0.005545676919381709 1.0803853604023411e-07 6.966421309286101 0.17212482236922688 LIEK(ub)LDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIEKLDIK 8 1 P13639 P13639 EEF2 Elongation factor 2 1 8177200.0 1842900.0 2110000.0 4224300.0 True False 2524269.932499888 2016773.2231630792 3226607.342189416 1.0 0.7989530743908145 1.2782338769110855 21.267434762313567 -6.792754925272026 1.48523503195724 0.8880341250958238 1.2837298536647903 0.8101332129660468 0.08562649563089195 0.23127789806447574 1.0077830607369989 0.045370909402558744 0.10601860506934432 1.611554787728064e-07 6.792754925272026 0.3956957285689665 LIEK(ub)LDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIEKLDIK 8 1 P13639 P13639 EEF2 Elongation factor 2 1 41737800.0 8111800.0 18827000.0 14799000.0 True False 10500885.00748318 17779260.89973689 12105733.850563047 1.0 1.693120235776981 1.152829865476692 23.324007586588827 -10.22097983255144 3.6608576582197347 0.9994092898569392 1.4229750504612777 0.4496945287008781 0.2205726213221471 57308879.170813575 96401940.59773469 389450.3636156005 0.08072132688390513 6.012016549964916e-11 10.22097983255144 0.4235657606043385 LIELQAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIELQAGK 8 0 K7ELL7;P14314-2;P14314;K7EPW7 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 26597200.0 7829200.0 6869000.0 11899000.0 False True 10264157.018080654 5844171.975152284 10667805.623267688 1.0 0.5693767120726603 1.03932603568671 23.291111809848573 -6.665718886944016 1.9527109749410658 0.7241259953475322 1.0373881666001499 0.26014559638688206 0.1831025084294797 0.47102957014054236 3.4584501215601153 0.07560358961711754 0.20311629124687444 2.1591415406036366e-07 6.665718886944016 0.3132621712526177 LIELQAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIELQAGK 8 0 K7ELL7;P14314-2;P14314;K7EPW7 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 15960700.0 6232800.0 2558800.0 7169100.0 False True 6034943.175662234 3580542.1839657184 5291297.641610088 1.0 0.593301722940053 0.8767767131509827 22.524908756116194 -10.079482394942687 5.681102206546668 1.0000015618056857 0.735039218045471 0.5380756205596404 0.11572818014303847 2.2893901532844923e-06 3.709170111266137e-07 0.11205398976121349 0.0373511095317158 8.327556828368411e-11 10.079482394942687 -0.26496234376021466 LIELQAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIELQAGK 8 0 K7ELL7;P14314-2;P14314;K7EPW7 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 20631300.0 7829200.0 5955700.0 6846400.0 False True 10723866.816174569 5692557.481133807 5229421.326034037 1.0 0.530830676911042 0.48764325552296284 23.354321871371464 -13.999999999999998 0.3375219209640173 6.345146124366732 0.48065226360051544 0.9997302335777165 0.0038108038225574807 19.478708665033466 0.18620662900128235 74.19382553317352 0.013462457035619586 1.0000000000000041e-14 13.999999999999998 -5.864493860766216 LIELQAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIELQAGK 8 0 K7ELL7;P14314-2;P14314;K7EPW7 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 12108400.0 6232800.0 3783400.0 2092200.0 False True 5182849.3598571075 3763018.0732538975 2529669.346760184 1.0 0.7260519864612938 0.48808467526633414 22.30531403155047 -6.972772864735799 0.18002915713057188 1.1838902745656739 0.0238111534781519 0.9999967128104603 0.00037917686261960184 0.07541280831112067 0.0056777042708122715 0.009161447428722677 0.026702787027516252 1.0646997087469442e-07 6.972772864735799 -1.1600791210875219 down LIELYK(ub)EAGISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIELYKEAGISK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 22709100.0 9598600.0 9472600.0 3637900.0 True False 12583857.55297463 8059325.003905596 3261485.0052008983 1.0 0.6404494782285974 0.2591800639407217 23.585070909119395 -7.439805870030706 0.3289401497762125 1.0665034926852508 2.372173995815696e-13 0.9996315354277797 0.00580626554467512 0.11848040194747936 0.03201394233878759 0.018305862146947155 0.06096418089460382 3.632403872200505e-08 7.439805870030706 -1.0665034926850137 down LIELYK(ub)EAGISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIELYKEAGISK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 41277000.0 17835600.0 15100000.0 8341400.0 True False 17269418.64071386 21129508.745459717 6156537.103363937 1.0 1.2235217169178716 0.3564993837632421 24.041716180878236 -6.838270501725484 1.2902592383028884 1.1189558532829214 0.32892091944961993 0.9214555284774212 0.10300647850139753 0.1708348001766737 0.5531743745911754 0.06261449117449189 0.14420320763649036 1.4512074467729204e-07 6.838270501725484 -0.7900349338333015 down LIELYK(ub)EAGISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIELYKEAGISK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 72574600.0 17892100.0 21853200.0 32829300.0 True False 27143623.787721362 17953325.720169067 26340574.465406664 1.0 0.6614196343338062 0.9704148079639254 24.694110003670513 -10.384714331336859 8.192512063590481 1.0000016760149848 0.8159172217586405 0.3212140390918484 0.1261467513960807 3.861701170095206e-06 2.9014548604157325e-07 0.12214217876656203 0.040713688944598966 4.123686762926943e-11 10.384714331336859 -0.18408445425634434 LIELYK(ub)EAGISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIELYKEAGISK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 31188600.0 9598600.0 10555400.0 11034600.0 True False 13147461.812411645 10089027.525959982 8428454.744720615 1.0 0.76737454498142 0.6410708671360331 23.648280970642286 -13.999999999813266 0.07453658127464692 2.3003838976560114 0.22258429732224488 0.999908214755974 0.001424216793046262 12.313569846460108 0.07518960245122287 2.7127105438835546 0.382837376156807 1.0000000004299713e-14 13.999999999813266 -2.0777996003337664 LIELYK(ub)EAGISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIELYKEAGISK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 46479800.0 17835600.0 22693000.0 5951200.0 True False 14831091.651050478 22570748.304792155 7195568.404760167 1.0 1.5218534707924538 0.4851678200134721 23.822121456312512 -6.769845846205256 1.5748467272974036 1.2993934925810178 0.4793496868038457 0.7299665941681395 0.21992952147357728 0.266719425761668 1.3054412516706957 0.11007257861759302 0.2620765186978708 1.6988465548273782e-07 6.769845846205256 -0.8200438057771721 down LIELYK(ub)EAGISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIELYKEAGISK 12 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 60094700.0 17892100.0 21938500.0 20264100.0 True False 23161676.156018347 20717603.189508606 16576241.727224477 1.0 0.8944777161183703 0.7156753948015673 24.465236325762962 -6.963152683486033 0.3884548973618365 1.0111722085493355 0.5925722293785761 0.9998698527581779 0.0013387760372632652 0.07859355330993886 0.017105962369445296 0.0023106729054584003 0.015050497753151643 1.0885473290409594e-07 6.963152683486033 -0.4185999791707594 LIERDPYEHPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIERDPYEHPER 12 1 Q9H3S7 Q9H3S7 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 0 12107300.0 2321700.0 2496600.0 7289000.0 False True 3043771.1833747793 2124117.011670579 6534804.201025129 1.0 0.6978569950568577 2.1469433171318975 21.53742847710836 -6.852300349560885 1.2240122319690683 0.8383982531921147 2.207469387006853 0.9435758101957674 0.14827085668037834 0.1549463262581636 0.44557403056301764 0.09473118896855365 0.21955039123946785 1.405075465357565e-07 6.852300349560885 1.3690711338147383 up LIERDPYEHPER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIERDPYEHPER 12 1 Q9H3S7 Q9H3S7 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 0 27977500.0 4312700.0 3094800.0 20570000.0 False True 4175795.6991526266 4330569.779168796 15182099.913227526 1.0 1.037064571920407 3.6357381938748476 21.993619699088914 -6.9100061974871885 0.8956951390281583 0.9195554377635934 3.971614696608766 0.9909238275521756 0.11754811378773444 0.10441391459659471 0.13874604540566404 0.0962411097707565 0.26567954886782824 1.230251214705037e-07 6.9100061974871885 3.0520592588451727 up LIERDPYEHPER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIERDPYEHPER 12 1 Q9H3S7 Q9H3S7 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 0 37096800.0 3903800.0 18150000.0 15043000.0 False True 5922350.006008609 14910990.693402749 12069744.456418877 1.0 2.5177489811096234 2.037999180084483 22.497738324448132 -10.218010175937252 6.337324820845695 0.9999858499988513 2.277874080597054 0.9043965340957987 0.19585703611889654 3.915802482249457e-05 4.831449857044574e-06 0.1896398511837193 0.06321258659383525 6.053266912013969e-11 10.218010175937252 1.2778882305982027 LIERDPYEHPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIERDPYEHPER 12 1 Q9H3S7 Q9H3S7 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 0 23184100.0 2321700.0 1866400.0 18996000.0 False True 3180095.231583363 1783936.2766405528 14509536.03490049 1.0 0.5609694511419818 4.5626105441113545 21.60063853863125 -6.879696188883208 1.081449784216711 0.7289489355452262 4.844605324458757 0.9734413853502287 0.2920222192055204 0.12790151551242557 0.2738917402882981 0.2080593687345195 0.5027726274452023 1.319179248942265e-07 6.879696188883208 4.115656388913531 up LIERDPYEHPER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIERDPYEHPER 12 1 Q9H3S7 Q9H3S7 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 0 29214300.0 4312700.0 5834600.0 19067000.0 False True 3586201.1350044482 5803167.85172257 23053821.54415276 1.0 1.6181936353425899 6.428479796943727 21.77402497452319 -6.93061571632182 0.7417199954351658 0.9284948440841407 7.431672949321404 0.9966578638503771 0.140276639318365 0.09231950947405382 0.07612307887857679 0.12826967157822589 0.43378418818989567 1.1732330367966851e-07 6.93061571632182 6.5031781052372635 up LIERDPYEHPER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIERDPYEHPER 12 1 Q9H3S7 Q9H3S7 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 0 26045400.0 3903800.0 9718600.0 12423000.0 False True 5053546.055402351 9177751.36666401 10162141.470744288 1.0 1.8161012615790437 2.010893214257093 22.26886464654058 -10.879052867086108 0.27907920030358746 1.501114779865059e-11 2.0832371356509087 0.9991941790771025 0.012430884788708206 2.7016012460063825 0.14313321362331016 1.8476711521867877 0.07687834666304033 1.3211348013841577e-11 10.879052867086108 2.0832371356358976 LIETELLQLTQLELK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIETELLQLTQLELKR 16 1 Q6UWE0;Q6UWE0-3 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 1 10235600.0 3340300.0 3614100.0 3281200.0 True False 3234264.0048877755 5057228.977282517 2421755.2861099746 1.0 1.5636413631168602 0.7487809537038724 21.625006016533046 -6.720661798350808 1.7572115359581884 1.3426799217745422 0.7500295612632503 0.5154856729575201 0.23716393968889363 0.3540476146641584 2.1369325063863798 0.10715639920391526 0.26876526545336904 1.9025592985530106e-07 6.720661798350808 -0.5926503605112919 LIETELLQLTQLELK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIETELLQLTQLELKR 16 1 Q6UWE0;Q6UWE0-3 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 1 33731100.0 6207200.0 9441900.0 18082000.0 True False 9416776.207105052 7756919.175098597 14508084.774377856 1.0 0.8237340470346873 1.5406636470166257 23.166801813233576 -6.841672609210209 1.2745729572354503 0.9062421922088275 1.5650409535979624 0.9273012761356322 0.08224359992842631 0.16684988448376992 0.5257948541337766 0.05058238698708671 0.11659157448736145 1.439883618513777e-07 6.841672609210209 0.6587987613891348 LIETELLQLTQLELK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIETELLQLTQLELKR 16 1 Q6UWE0;Q6UWE0-3 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 1 8834300.0 3340300.0 2345300.0 3148700.0 True False 2777607.4503803537 2332665.403394399 3807078.6120561105 1.0 0.8398110406403806 1.3706323445866282 21.405411291967322 -6.825792752384624 1.3467382172895495 0.9141260929849632 1.3837130733369212 0.897157109632122 0.0712932341049396 0.18607042331891732 0.6614978914311143 0.04158258633746212 0.09572048064117429 1.4935069489381082e-07 6.825792752384624 0.469586980351958 LIETELLQLTQLELK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIETELLQLTQLELKR 16 1 Q6UWE0;Q6UWE0-3 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 1 25183200.0 6207200.0 7394000.0 11582000.0 True False 8035342.762204397 6982517.400151632 9474194.841355592 1.0 0.8689756749388579 1.1790654265452223 22.937928135326025 -6.791896168276053 1.4886003220572157 0.9269508750178217 1.1825447675090324 0.8074558842622043 0.0557708592568444 0.2325346520059801 1.017878424313628 0.02948552150499995 0.06894312661770009 1.6147445660396167e-07 6.791896168276053 0.2555938924912107 LIFAGK(ub)QLEDGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIFAGKQLEDGR 12 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 39519690710.0 18406569410.0 20928716010.0 184405290.0 True False 24131190745.981705 17806233160.80405 165324799.5312468 1.0 0.7378928519625216 0.006851083366401075 34.49018005551464 -7.35061504520687 0.7733450272375884 0.9902027574338774 1.2570984946033972e-19 0.9886633939823003 0.04474515592022819 0.10835432994090398 0.13208384784700053 0.03861317763678462 0.07087962240357758 4.460514492855215e-08 7.35061504520687 -0.9902027574338774 down LIFAGK(ub)QLEDGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIFAGKQLEDGR 12 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 51799564840.0 16189263760.0 35393749510.0 216551570.0 True False 15675344443.493773 49526658265.308464 159830217.4091535 1.0 3.159525995989521 0.010196281044114014 33.86777809342953 -6.722170280004403 1.751719533637835 2.3107924546721352 0.014569452379062696 0.5226439821924725 0.9085027683428423 0.35111770936184 2.1067998922437368 0.41163813927288134 1.0306539512806214 1.8959623985590902e-07 6.722170280004403 -2.2962230022930727 LIFAGK(ub)QLEDGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIFAGKQLEDGR 12 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 54376899630.0 52862931220.0 649393900.0 864574510.0 True False 80196931458.68156 533504484.8073004 693690979.1420305 1.0 0.006652430150425 0.008649844408316652 36.222827985378814 LIFAGK(ub)QLEDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIFAGKQLEDGR 12 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 96026682840.0 18406569410.0 35349811240.0 42270302190.0 True False 25211975539.712 33787939693.223335 32286927396.922344 1.0 1.3401543897265458 1.2806187022538718 34.55339011703754 -10.07922656600925 4.416489521950945 0.9999744197487966 1.3103865459861053 0.9731472468703296 0.024305342722989783 16883821.22387699 0.3515464158165016 4571.742236920454 0.008320365284755764 8.332463769804483e-11 10.07922656600925 0.3104121262373086 LIFAGK(ub)QLEDGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIFAGKQLEDGR 12 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 64909889810.0 16189263760.0 19715570790.0 29005055260.0 True False 13462090122.428753 19609359096.919956 35069878210.64306 1.0 1.4566355535125588 2.6050841950771275 33.648183368863805 -6.955333144580642 0.49685948885608244 0.9763606465568876 3.1346288531616913 0.999556060501536 0.014227572825969143 0.08141230009004477 0.027627049555708723 0.016785491519530158 0.09472813416122372 1.1083243004532829e-07 6.955333144580642 2.1582682066048036 up LIFAGK(ub)QLEDGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIFAGKQLEDGR 12 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 54078367760.0 52862931220.0 720126800.0 495309740.0 True False 68432106548.44936 680051110.5376673 405168449.62710893 1.0 0.009937603046841714 0.005920736187483181 35.993954307471256 LIFAGK(ub)QLEDGRTLSDYNIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIFAGKQLEDGRTLSDYNIQK 21 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 2274065000.0 542523200.0 667153800.0 1064388000.0 True False 711253169.0021421 567617053.5851442 954255340.0906483 1.0 0.7980520556154241 1.341653551335916 29.405787934487876 -6.8061490310010875 1.4310051825230943 0.8894290766127926 1.3503173993192636 0.8494351005554921 0.08705541817440333 0.2121072773613017 0.8568045157440848 0.0478485076654475 0.11087142793092311 1.5626113302956048e-07 6.8061490310010875 0.46088832270647107 LIFAGK(ub)QLEDGRTLSDYNIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIFAGKQLEDGRTLSDYNIQK 21 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 3010179000.0 741264300.0 871093400.0 1397821300.0 True False 717733270.5440629 1218925537.3120706 1031689967.7898692 1.0 1.6982987794171633 1.4374280949910794 29.418872557524182 -10.45474279085988 5.671042828311699 0.9995407312258007 1.567863437204122 0.8633496567576995 0.10650001094908948 0.0006188945095043852 5.950496483578422e-05 0.10319784926158256 0.034372730731393845 3.5095966684917035e-11 10.45474279085988 0.5683227059783214 LIFAGK(ub)QLEDGRTLSDYNIQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIFAGKQLEDGRTLSDYNIQK 21 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 13089863000.0 2605015000.0 4845735000.0 5639113000.0 True False 3951998207.1065454 3980975729.3496394 4524539843.838973 1.0 1.0073323723150953 1.144873961658908 31.879935146405035 -6.9179269292858 0.8399725890436811 0.9967325578862252 1.1660286069040415 0.993585076463033 0.0053368687826088335 0.09940695472500448 0.11205300693107259 0.004548470567873884 0.013365872979243361 1.2080170687379566e-07 6.9179269292858 0.16929604901781636 LIFAGK(ub)QLEDGRTLSDYNIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIFAGKQLEDGRTLSDYNIQK 21 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 2581042500.0 542523200.0 857359300.0 1181160000.0 True False 743108688.1782093 819478331.2179333 902194334.753793 1.0 1.102770488697892 1.2140812630862854 29.468997996010767 -6.970105495309416 0.25566335178198824 0.9670474198137228 1.3530881760393279 0.9999831866517886 0.00035841729781648657 0.07626855900533216 0.008908035891911643 0.0023903701285733713 0.010572151264162982 1.0712590520291068e-07 6.970105495309416 0.3860407562256051 LIFAGK(ub)QLEDGRTLSDYNIQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIFAGKQLEDGRTLSDYNIQK 21 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 2741289100.0 741264300.0 983018700.0 1017006100.0 True False 616394109.026428 977722983.1491641 1229657373.4050882 1.0 1.5861978056432788 1.994920709653256 29.199277832958458 -7.708489729725161 0.10929273951405209 1.7777335964928103e-19 3.290403032221881 0.999992520573408 0.0011166890455937865 0.13862541381437166 0.013217381739923612 0.16242833516043934 0.2162225670214347 1.9566370382961195e-08 7.708489729725161 3.290403032221881 LIFAGK(ub)QLEDGRTLSDYNIQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIFAGKQLEDGRTLSDYNIQK 21 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 13644846000.0 2605015000.0 4398487000.0 6641344000.0 True False 3372243270.022534 4153707331.8691745 5432687537.944048 1.0 1.2317341897583263 1.6110010764163363 31.651061468497485 -6.963768137671594 0.3786032924783633 0.9735354300077333 1.8825819164165007 0.9998854503404465 0.002695515911374235 0.0783815595543309 0.016349684539409777 0.004943119805862325 0.032069324914505544 1.0870058023668402e-07 6.963768137671594 0.9090464864087674 LIFAGK(ub)QLEDGRTLSDYNIQKESTLHLVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIFAGKQLEDGRTLSDYNIQKESTLHLVLR 30 3 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 121200000.0 37805000.0 40090000.0 43305000.0 True False 36604900.96841075 56098146.06658819 31962121.377847265 1.0 1.5325310158604089 0.8731650826054657 25.12553348565706 -6.691811375725794 1.8599447279524084 1.3333033859091965 0.8753956772643487 0.378842144557181 0.22514268540419674 0.4128390173504651 2.7703569414779365 0.09678518785529924 0.2514646599882015 2.0332399029449797e-07 6.691811375725794 -0.45790770864484776 LIFAGK(ub)QLEDGRTLSDYNIQKESTLHLVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIFAGKQLEDGRTLSDYNIQKESTLHLVLR 30 3 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 105364000.0 37805000.0 29837000.0 37722000.0 True False 31436532.54546877 29676262.158819165 45609495.793178335 1.0 0.9440055806376353 1.450843719077804 24.905938761091335 -6.879491639815524 1.0825980596870337 0.965521047175744 1.4864193384176143 0.973274480526394 0.03709059068895691 0.12808284649656246 0.27499728728101086 0.026403166339362735 0.0637696995967015 1.319800717674107e-07 6.879491639815524 0.5208982912418703 LIFAGKQLEDGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIFAGKQLEDGR 12 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 26494000.0 5833600.0 4662300.0 15998100.0 False True 4850896.872298545 4637183.264505911 19343228.74314314 1.0 0.9559434856236454 3.9875571986706784 22.209820078190038 -6.903603300492532 0.9382035298826364 0.8861127708697384 4.330130076507805 0.9882753888927581 0.15363301108992275 0.10880144915433394 0.16283742592899847 0.12193181639084481 0.3233850617100001 1.24852343776369e-07 6.903603300492532 3.4440173056380665 up LIFELWQDREK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIFELWQDREK 11 1 B7Z4T2;B7Z3R9;E9PDB7;Q8TE99-2;Q8TE99 B7Z4T2 PXYLP1 2-phosphoxylose phosphatase 1 0 13082100.0 3148100.0 3564300.0 6369700.0 False True 2617784.6344766617 3545098.408441847 7701574.819834779 1.0 1.3542360825838413 2.942020026553655 21.31991498075817 -6.94226961394722 0.6380986078714078 0.9826387236956325 3.400386241695042 0.9984463338254604 0.03328563678453698 0.08674628938063009 0.05000764117829912 0.032988129022178014 0.1353499216214094 1.1421690457592418e-07 6.94226961394722 2.4177475179994095 up LIFPYVELDLHSYDLGIENR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIFPYVELDLHSYDLGIENR 20 0 O75874;C9J4N6;C9JLU6;C9JJE5 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 102095000.0 30321000.0 39975000.0 31799000.0 False True 45999173.76202351 32841148.923899412 25513913.712003153 1.0 0.7139508438521729 0.5546602607255351 25.455104611899955 -13.475683899152203 0.07315801891115131 2.5170514702924183 5.457360961783971e-09 0.9999239369602867 0.0016068902784842562 10.286976220571546 0.06893071001001332 2.7632693625201687 0.482132831424621 3.344383721290118e-14 13.475683899152203 -2.5170514648350575 LIFPYVELDLHSYDLGIENR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIFPYVELDLHSYDLGIENR 20 0 O75874;C9J4N6;C9JLU6;C9JJE5 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 49802200.0 30321000.0 6027200.0 13454000.0 False True 39251132.21626491 5691781.021665391 11005510.04969763 1.0 0.14500934623503234 0.28038707237946014 25.226230933992404 -9.958550817351288 5.626245728171578 1.000001088158757 0.21269821264183342 0.9783055943146945 0.05526772526842226 73424057.52055517 129961811.42301597 695.605195656416 0.01891962071696229 1.1001431086156441e-10 9.958550817351288 -0.7873028755169237 LIFQMPQNKSTK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIFQMPQNKSTK 12 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2;E9PDT6;P46940;H0YLE8;A0A0J9YXZ5 Q13576;P46940 IQGAP2;IQGAP1 Ras GTPase-activating-like protein IQGAP2;Ras GTPase-activating-like protein IQGAP1 1 7269500.0 3084400.0 2051600.0 2133500.0 True False 3992816.6026136125 1937426.6564986585 1745224.8915586371 1.0 0.48522806062028 0.43709117278671156 21.92897537718889 -13.999999999999998 0.33523051747009325 6.783637683031768 0.429079472034988 0.999725593010027 0.004220334834043161 19.274692175410127 0.1854388897643865 78.80899951249273 0.015130662412652216 1.0000000000000041e-14 13.999999999999998 -6.35455821099678 LIFSTITSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIFSTITSK 9 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 30644300.0 9346600.0 6949700.0 14348000.0 False True 12253483.112603163 5912831.849718425 12863406.595734468 1.0 0.4825429467999069 1.0497755191341454 23.54668856486889 -6.66663609483575 1.9492738142020618 0.668769971815303 1.0474573639301463 0.2643539392243768 0.21997391926822926 0.4688159490084479 3.4309408215526194 0.09095533160764044 0.24408294177114076 2.1545863551672278e-07 6.66663609483575 0.37868739211484337 LIFSTITSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIFSTITSK 9 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 24366000.0 6822200.0 3546800.0 13997000.0 False True 6605632.995283473 4963055.736317662 10330765.79900078 1.0 0.7513368877534313 1.5639327535116028 22.655265385966548 -6.824567080499845 1.3519275409115799 0.8665532346857866 1.5834818654447476 0.8945794864365177 0.11038054609909048 0.18761377673579183 0.6724907905474071 0.06413736215058193 0.1476827807670082 1.4977278982850717e-07 6.824567080499845 0.716928630758961 LIFSTITSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIFSTITSK 9 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 24315600.0 5230700.0 15106000.0 3978900.0 False True 7935354.31539251 12410216.276283303 3192468.6709861737 1.0 1.5639145755862132 0.4023095307532293 22.91986321048767 -6.774688761449969 1.5563690911457788 1.3215087567600867 0.3945642670712918 0.7482023720457959 0.23799611611102908 0.25892170140685766 1.2383265395060514 0.12048514759691957 0.2856052736417302 1.6800075696840405e-07 6.774688761449969 -0.926944489688795 down LIFSTITSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIFSTITSK 9 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 34240600.0 9346600.0 8025000.0 16869000.0 False True 12802290.60236771 7670428.964873797 12884889.627960423 1.0 0.5991450438920044 1.0064518942865925 23.609898626391782 -10.866855007319181 10.97701678606457 1.0068135815211896 0.8027984690893422 0.23812274480248385 0.166282325367811 0.02786068952157452 0.0003379337814004139 0.16177654234798944 0.05366738974318126 1.358767006086055e-11 10.866855007319181 -0.20401511243184745 LIFSTITSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIFSTITSK 9 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 14834900.0 6822200.0 4825700.0 3187000.0 False True 5672961.574704324 4799702.996273545 3853386.9649769166 1.0 0.8460665444439761 0.6792549031460267 22.435670661400824 -6.9700982278613095 0.25582769114048626 1.0492838172037071 0.47111530418332637 0.9999831373506818 0.0005378224648197616 0.0762708224680697 0.008915960782297548 0.0035783560821319874 0.015839510827427388 1.0712769785398808e-07 6.9700982278613095 -0.5781685130203807 LIFSTITSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIFSTITSK 9 0 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 0 18832800.0 5230700.0 9152800.0 4449300.0 False True 6771244.2625116855 8643438.634042172 3639573.053673237 1.0 1.276491926586625 0.5375043215946836 22.69098953258012 -6.805379162139 1.4338985350218814 1.151531549760668 0.525903419885801 0.8473950401070769 0.11909232332794344 0.21318031192600098 0.8646952590865745 0.0653229577947571 0.15144401861922543 1.5653838101786551e-07 6.805379162139 -0.6256281298748669 LIGDAAK(ub)NQVALNPQNTVFDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIGDAAKNQVALNPQNTVFDAK 22 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 47303000.0 17675000.0 22647000.0 6981000.0 True False 23172096.164943468 19268155.87731458 6258673.086480515 1.0 0.8315240770692524 0.27009524912766064 24.465885221577082 -6.949068056195656 0.5689882194162555 1.0070258668010286 0.06734484481792523 0.9991260654340607 0.009224785419541949 0.08386224744262405 0.0375286545635807 0.009784410199685345 0.046766454103395014 1.1244287563477172e-07 6.949068056195656 -0.9396810219831033 down LIGDAAK(ub)NQVALNPQNTVFDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIGDAAKNQVALNPQNTVFDAK 22 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 86154000.0 40379000.0 27819000.0 17956000.0 True False 39097190.74734712 38927271.7741685 13252784.931546612 1.0 0.9956539339545732 0.3389702604769848 25.220561613420024 -6.908351246591339 0.906884222943911 1.0214079393237119 0.2570297415811244 0.9902843787649307 0.03061449362574666 0.10551886172177102 0.14475447445188655 0.024861874967745255 0.06787121998841464 1.2349482339731947e-07 6.908351246591339 -0.7643781977425874 down LIGDAAK(ub)NQVALNPQNTVFDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIGDAAKNQVALNPQNTVFDAK 22 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 265518000.0 65960000.0 70098000.0 129460000.0 True False 100066142.32192431 57588464.22182618 103872174.2556662 1.0 0.5755039905161673 1.0380351619981256 26.576378675660713 -6.665459610609549 1.9547081091488285 0.7279794086427347 1.036084626337806 0.258666552790056 0.18051028351255366 0.471565692392674 3.4695462543422053 0.07448329689737598 0.20009623140972532 2.160430945528259e-07 6.665459610609549 0.3081052176950714 LIGDAAK(ub)NQVALNPQNTVFDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIGDAAKNQVALNPQNTVFDAK 22 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 43053300.0 17675000.0 18296000.0 7082300.0 True False 24209925.148915004 17487622.223218806 5409606.604547048 1.0 0.7223327670636163 0.22344582113627418 24.529095283099974 -7.146747788193595 0.45534701862024246 1.0166157511892893 2.1817599616763803e-12 0.9995718375955398 0.0066480799933292985 0.08121792778293928 0.02778456204581065 0.00856160815759486 0.042504368791455624 7.132671320171991e-08 7.146747788193595 -1.0166157511871075 down LIGDAAK(ub)NQVALNPQNTVFDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIGDAAKNQVALNPQNTVFDAK 22 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 79747900.0 40379000.0 32453000.0 6915900.0 True False 33576927.59300314 32278169.247583847 8361982.714491319 1.0 0.9613199170227257 0.24903954333909378 25.0009668888543 -6.918116857532159 0.8385886920199485 1.0168084978487386 0.13901510402997436 0.9936412132293846 0.027530964155195504 0.09929283290110676 0.11145439363016814 0.023487053535766012 0.0691353753422901 1.2074888870293984e-07 6.918116857532159 -0.8777933938187643 down LIGDAAK(ub)NQVALNPQNTVFDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIGDAAKNQVALNPQNTVFDAK 22 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 286126000.0 65960000.0 82256000.0 137910000.0 True False 85386520.26598167 77678381.29116471 112811795.07609639 1.0 0.9097265124424104 1.3211897466331235 26.347504997753163 -6.8491996313733745 1.2389276020686373 0.9518578715881315 1.3373882158993389 0.9391380576293199 0.04356186135499829 0.1583367484600764 0.46808665958354145 0.027518986817741804 0.06364963179348357 1.4151431340961656e-07 6.8491996313733745 0.38553034431120736 LIGDAAK(ub)NQVAMNPTNTVFDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIGDAAKNQVAMNPTNTVFDAK 22 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 136846000.0 38533000.0 75613000.0 22700000.0 True False 50517136.15410277 64331835.137165576 20351221.753775626 1.0 1.273465600680945 0.4028577885273251 25.59026951843232 -6.822311015548137 1.3621732991215476 1.1470574374815226 0.38294415603519927 0.8895422677254575 0.12081648800669165 0.1905010100539007 0.6939762815816047 0.06969192842798025 0.16051209610005227 1.5055285112008246e-07 6.822311015548137 -0.7641132814463233 down LIGDAAK(ub)NQVAMNPTNTVFDAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LIGDAAKNQVAMNPTNTVFDAK 22 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 267618900.0 119196700.0 111565900.0 36856300.0 True False 115412866.0034748 156114745.67848247 27202529.364700466 1.0 1.3526632782326213 0.23569754661392314 26.782228820905157 -6.821806905442743 1.364055814235371 1.1897335099655768 0.2103541742974324 0.8885114803250395 0.15566608986385613 0.19112351619774598 0.6982663261189527 0.08966893061193575 0.20657775404017847 1.5072770777100906e-07 6.821806905442743 -0.9793793356681444 down LIGDAAK(ub)NQVAMNPTNTVFDAK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LIGDAAKNQVAMNPTNTVFDAK 22 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 339866500.0 185946500.0 90831000.0 63089000.0 True False 282094435.010062 74621498.38415785 50619431.497108996 1.0 0.2645266588881705 0.179441439514053 28.071602964680032 -13.999999999999998 0.30439196762290993 7.880962222888573 0.15944363150756583 0.9996596060023413 0.006796920043922776 16.880203014279555 0.17535204524825865 73.33688489133432 0.030179934887974658 1.0000000000000041e-14 13.999999999999998 -7.721518591381007 LIGDAAK(ub)NQVAMNPTNTVFDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LIGDAAKNQVAMNPTNTVFDAK 22 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 154631300.0 51230000.0 71751600.0 31649700.0 True False 70171115.43869391 68581377.06118856 24174692.706032287 1.0 0.9773448324489833 0.34451059463566436 26.064373959857775 -6.914486308186506 0.8646312547845341 1.0169247932989898 0.2543674722225626 0.9925071039684826 0.026297527664136188 0.10152564946608152 0.12323057625826919 0.02201958242451828 0.06284975954867647 1.2176253797866188e-07 6.914486308186506 -0.7625573210764272 down LIGDAAK(ub)NQVAMNPTNTVFDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LIGDAAKNQVAMNPTNTVFDAK 22 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 245470500.0 119196700.0 111433300.0 14840500.0 True False 99117337.35914499 110832986.69512172 17943579.9352808 1.0 1.1181997988255663 0.18103371633424178 26.562634096339433 -6.875267381877838 1.1058996481728471 1.0695280340243507 0.12037354746522165 0.9696611713911287 0.07258580463129667 0.131902530106104 0.2983489730317138 0.050758640113880864 0.12139618198063652 1.3327006763383121e-07 6.875267381877838 -0.949154486559129 down LIGDAAK(ub)NQVAMNPTNTVFDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LIGDAAKNQVAMNPTNTVFDAK 22 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 369551500.0 185946500.0 130759000.0 52846000.0 True False 240711409.8034923 123482146.70360103 43228570.24575002 1.0 0.5129883407039458 0.17958671041410204 27.84272928677248 -8.227745477155054 0.3069560212828739 1.1397915825845344 4.8749717381803694e-23 0.9988839769548915 0.01125424534450322 0.09503235607374602 0.07150995437216945 0.08134114621507293 0.09402105409984758 5.9190842669844204e-09 8.227745477155054 -1.1397915825845344 down LIGEELAQLK(ub)EQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIGEELAQLKEQR 13 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 228334000.0 64307000.0 101520000.0 62507000.0 True False 84307099.74987386 86373611.72186065 56039375.24948255 1.0 1.0245117193939515 0.6647052907257244 26.329150794105292 -6.890586805911666 1.018925680059297 1.019061788460445 0.6334028679459123 0.9812704873704184 0.022463816476069397 0.11866750414820146 0.21908715544603877 0.016785577445258642 0.04193526384004161 1.2865100822692495e-07 6.890586805911666 -0.38565892051453265 LIGEELAQLK(ub)EQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIGEELAQLKEQR 13 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 359580000.0 123520000.0 115680000.0 120380000.0 True False 119598925.21142967 161871627.2632307 88848866.67741029 1.0 1.3534538623743517 0.7428901766495081 26.833629183759435 -6.74973281112044 1.6507044171657064 1.2078980035099265 0.7416910774516704 0.6478881846103213 0.14852189440873884 0.3005038607459225 1.6109257376645287 0.07107708165354032 0.17261311746857078 1.7793737888322257e-07 6.74973281112044 -0.4662069260582561 LIGEELAQLK(ub)EQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIGEELAQLKEQR 13 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 456860000.0 199080000.0 113480000.0 144300000.0 True False 302018914.6975241 93228607.37671322 115779041.75106324 1.0 0.30868466456838606 0.38335030064927383 28.170063663900265 -10.43871956472612 6.04353714918914 1.0002651227384998 0.34601748261682336 0.9903184385741854 0.030482118286419863 0.00010893193077926904 1.0116855766807518e-05 0.02952574402886215 0.009838061373368989 3.641501014431043e-11 10.43871956472612 -0.6542476401216764 LIGEELAQLK(ub)EQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIGEELAQLKEQR 13 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 309264000.0 64307000.0 148720000.0 96237000.0 True False 88083035.73133117 142149058.64872658 73507802.66323005 1.0 1.6138074428123292 0.8345284884077093 26.392360855628183 -6.6966818669239485 1.8425383701378937 1.3823802790917956 0.8369742655014645 0.4019036135631444 0.25925626673358 0.4024752755122756 2.6540191161332816 0.112348485011849 0.290137637681956 2.0105650694791312e-07 6.6966818669239485 -0.5454060135903311 LIGEELAQLK(ub)EQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIGEELAQLKEQR 13 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 347554000.0 123520000.0 147540000.0 76494000.0 True False 102712352.86380915 146745172.73560297 92488541.7317052 1.0 1.4287003329597452 0.9004617181181688 26.61403445919371 -6.690850456301489 1.8633387932962386 1.2685594821090522 0.9022690545495305 0.3743499016919629 0.18128009145246105 0.41489141410931074 2.793553357739669 0.07780851174765892 0.2024059472901229 2.03774362762678e-07 6.690850456301489 -0.3662904275595217 LIGEELAQLK(ub)EQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIGEELAQLKEQR 13 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 415584000.0 199080000.0 131070000.0 85434000.0 True False 257712984.45348135 123775839.28021015 69885888.62686703 1.0 0.4802856151881334 0.2711772120255036 27.941189985992715 -12.826533630582066 0.14021273784400073 2.802600120672762 1.3586892611141486e-21 0.9996279528193491 0.005910292722902574 7.751484597262715 0.10613400076998675 4.112848459822083 0.225687778822849 1.4909612949996048e-13 12.826533630582066 -2.802600120672762 LIGIYK(ub)TYNITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIGIYKTYNITK 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 12163800.0 2760900.0 4128600.0 5274300.0 True False 3619566.6365936357 3512628.9731567535 4728566.0306581 1.0 0.9704556721360652 1.3063901028516884 21.787385546007403 -6.885469411715747 1.0488416610193902 0.9799410448087676 1.3328406877873378 0.9778353091065581 0.022611164841118397 0.1228948393803935 0.2439530805884143 0.01651655277478675 0.04055758432105359 1.3017589980060465e-07 6.885469411715747 0.3528996429785701 LIGIYK(ub)TYNITK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIGIYKTYNITK 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 188409100.0 13060100.0 77266000.0 98083000.0 True False 19813126.5212032 63477278.61798665 78696852.05869386 1.0 3.2037991858607398 3.9719552577668997 24.239953220396917 -9.440436287295762 0.32190943735779476 1.634353794039929e-21 4.222930751234794 0.9985540662033402 0.0478968109163945 0.8157101426250721 0.128187880655485 1.1516799776953124 0.24715077866494217 3.6271349383438603e-10 9.440436287295762 4.222930751234794 LIGIYK(ub)TYNITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIGIYKTYNITK 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 22243200.0 2760900.0 7298300.0 12184000.0 True False 3781679.3405170883 6975836.973749332 9306390.13735669 1.0 1.844639998693144 2.4609146623426246 21.850595607530295 -7.529828742018129 0.1364862782681597 2.437572792752635e-11 3.9783228589431316 0.9999891033315046 0.001976768141729277 0.1362300798405752 0.01292629572153223 0.13582908763675386 0.21721022289495726 2.9523732244206865e-08 7.529828742018129 3.978322858918756 LIGIYK(ub)TYNITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIGIYKTYNITK 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 126711100.0 13060100.0 49973000.0 63678000.0 True False 16906556.903058626 47191958.62020248 52089257.391455725 1.0 2.7913405958882627 3.0810092019405837 24.011079542489366 -10.20779642277407 0.406486464903165 2.1197120131133233e-14 3.1066816917835713 0.9990998426150594 0.027612933779645618 1.5714044831051284 0.1868795317198733 1.8481501201390464 0.07237185453766096 6.197315085532778e-11 10.20779642277407 3.10668169178355 LIGNMALLPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIGNMALLPIR 11 0 O15145;C9JZD1;F8VR50 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 0 9058000.0 1994500.0 3408300.0 3655200.0 False True 2731920.5493358416 3257710.036259104 2791917.0412070043 1.0 1.1924614854012088 1.021961287229143 21.381484096603014 -10.799378953243414 2.595473581528064 0.9676779122583256 1.1072113864616244 0.3452044513855177 0.0696064175265057 24716317.41763796 17881051.17639926 5040734.770002324 0.027377670085165465 1.5871612316121552e-11 10.799378953243414 0.13953347420329887 LIGNMALLPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIGNMALLPIR 11 0 O15145;C9JZD1;F8VR50 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 0 5045000.0 2314300.0 1525200.0 1205500.0 False True 1924442.9908736523 1516983.4448715036 1457564.4763977646 1.0 0.7882714385749762 0.757395507848255 20.87600950313747 -13.999999999999998 0.2711523707065153 2.6443565700584 0.7472605852470037 0.9995858085235803 0.002194447136043891 14.939512911495273 0.16484651813796125 13.55114456160631 0.01274971068782913 1.0000000000000041e-14 13.999999999999998 -1.8970959848113966 LIGQIVSSITASLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIGQIVSSITASLR 14 0 Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4 Q71U36 TUBA1A;TUBA3E Tubulin alpha-1A chain;Tubulin alpha-3E chain 0 349200000.0 105550000.0 121290000.0 122360000.0 False True 160127066.7386159 99644851.85690464 98175492.36770692 1.0 0.6222861249282755 0.6131099155645192 27.254641950457763 LIGQIVSSITASLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIGQIVSSITASLR 14 0 Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4 Q71U36 TUBA1A;TUBA3E Tubulin alpha-1A chain;Tubulin alpha-3E chain 0 210519000.0 105550000.0 55502000.0 49467000.0 False True 136636555.70155185 52413264.90982086 40464513.574282244 1.0 0.3835962099652485 0.2961470549848079 27.025768272550213 -13.999999999999998 0.2750860929390721 5.890256099691043 0.2685208481529449 0.9995943622368494 0.006308564577199507 15.138696523633387 0.16608198434001553 41.527923400369396 0.03541951370633829 1.0000000000000041e-14 13.999999999999998 -5.621735251538098 LIGVYTDFAFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIGVYTDFAFR 11 0 Q5SY16 Q5SY16 NOL9 Polynucleotide 5-hydroxyl-kinase NOL9 0 20113100.0 4737200.0 7928200.0 7447700.0 False True 7186678.735709829 6513350.766690667 5975658.830557124 1.0 0.9063088815041267 0.8314910197480683 22.776893764391666 -6.9736692131103215 0.14598285419063112 1.0920285380804673 0.6438102489768243 0.9999987015061933 7.834248023780492e-05 0.07512905371416431 0.004445186640261048 0.003976034502037597 0.009490984215557448 1.0625045215448216e-07 6.9736692131103215 -0.44821828910364303 LIGVYTDFAFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIGVYTDFAFR 11 0 Q5SY16 Q5SY16 NOL9 Polynucleotide 5-hydroxyl-kinase NOL9 0 16739900.0 4737200.0 6999600.0 5003100.0 False True 6132398.78417236 6610066.106857089 4092587.1361410883 1.0 1.0778924103757868 0.6673713305638247 22.548020086484115 -6.8575925440067484 1.19781116656664 1.0420208032486866 0.6483840517648525 0.9506491720475898 0.03954837107378469 0.14930324059545036 0.4084187926016765 0.02577547403129402 0.060015021909861264 1.3880574966155546e-07 6.8575925440067484 -0.39363675148383415 LIHDGCLLWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIHDGCLLWK 10 0 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 0 5136600.0 1569800.0 1411300.0 2155500.0 False True 2058023.0019648229 1200739.541204312 1932469.537016009 1.0 0.5834432074169965 0.9389931673120532 20.972827676257285 -10.1076583880882 7.3732536783633575 1.000000062884002 0.7612181873645248 0.37553372551739705 0.145152663301652 1.500095784214924e-07 1.8178237611690992e-08 0.14054349750851597 0.04684782063541255 7.804437587897632e-11 10.1076583880882 -0.23878187551947716 LIHDGCLLWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIHDGCLLWK 10 0 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 0 3638930.0 1569800.0 636230.0 1432900.0 False True 2150197.4822498877 608119.2548687414 1094478.5315018361 1.0 0.2828201873961957 0.5090130281227071 21.036037737780177 -10.276677053531996 5.112161231498714 1.00012115773859 0.3959166077597875 0.904851391503101 0.09234284054232986 0.00012754081097069412 1.8045875562937874e-05 0.08942831868899569 0.029803523630079508 5.2883835599973705e-11 10.276677053531996 -0.6042045499788025 LIHFSGVALGEACTIVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIHFSGVALGEACTIVLR 18 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 151023100.0 79904300.0 40366800.0 30752000.0 False True 121220664.88680628 33163029.152752046 24673853.7209196 1.0 0.273575707439974 0.20354494626769792 26.85306041986026 -13.999999999999998 0.33079780298333866 8.945729961686824 0.19125808694575605 0.9997164957335798 0.006062923557714067 18.89079993785204 0.18396071524102028 104.47345882124488 0.02237487473760505 1.0000000000000041e-14 13.999999999999998 -8.754471874741068 LIHIPINNIIVGG ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIHIPINNIIVGG 13 0 P60059 P60059 SEC61G Protein transport protein Sec61 subunit gamma 0 10092700.0 2534800.0 3921600.0 3636300.0 False True 3323147.347038119 3336512.5662770695 3260050.5578526156 1.0 1.0040218557419256 0.9810129426726321 21.664118832299447 -6.861798802293553 1.1766960438525502 1.0021931787633374 0.9798602853461624 0.9557847264870031 0.00210984191766258 0.1449553839753744 0.380377776323766 0.0013974782006624217 0.0032688369293799382 1.374678681561781e-07 6.861798802293553 -0.022332893417174926 LIHIPINNIIVGG ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIHIPINNIIVGG 13 0 P60059 P60059 SEC61G Protein transport protein Sec61 subunit gamma 0 9310900.0 3457800.0 2664700.0 3188400.0 False True 3348034.031704023 3728728.606226929 2353262.390050301 1.0 1.1137069011001501 0.7028788739201014 21.674882761824467 -6.832873327283831 1.3149123397767255 1.060649137535739 0.691152240088658 0.9115143889465255 0.05152153831765378 0.17729607805922115 0.598479472434023 0.03075389130090915 0.07077794739393084 1.4693547887767743e-07 6.832873327283831 -0.3694968974470809 LIHIPINNIIVGG ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIHIPINNIIVGG 13 0 P60059 P60059 SEC61G Protein transport protein Sec61 subunit gamma 0 19510000.0 2534800.0 6006200.0 10969000.0 False True 3471984.0603943313 5740826.224152641 8378348.113646215 1.0 1.653471365159616 2.4131297747647613 21.72732889382234 -6.969146804198005 0.2778074859234837 0.8281638155446149 3.2615167061160646 0.9999749425909014 0.0028905598114385444 0.07658051900807422 0.010017008709608368 0.014211423250970035 0.06992218667204626 1.0736264339566753e-07 6.969146804198005 2.4333528905714497 LIHIPINNIIVGG ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIHIPINNIIVGG 13 0 P60059 P60059 SEC61G Protein transport protein Sec61 subunit gamma 0 8192100.0 3457800.0 2081500.0 2652800.0 False True 2875313.9065129436 2070286.5463545984 3207488.2148386477 1.0 0.7200210528892661 1.115526276130508 21.455288037258743 -6.716562380335399 1.771857047362414 0.8290379093896496 1.1147860583547766 0.4961383178856439 0.11786893245518915 0.3620554397967854 2.219528798211508 0.05286099480545924 0.13323177448963017 1.9206030741372725e-07 6.716562380335399 0.285748148965127 LIHITIEPLYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIHITIEPLYR 11 0 Q8NI27;A0A0C4DG98 Q8NI27 THOC2 THO complex subunit 2 0 14487000.0 6442500.0 4162900.0 3881600.0 False True 6237986.3639462 5825167.679236711 2864892.514496065 1.0 0.933821803924506 0.4592655942716283 22.572648968350972 -6.932190396661671 0.7285867145502103 1.0066624256478758 0.35617447952758635 0.9969515256606771 0.013296752843424062 0.09151630580124476 0.07222422799443795 0.012275831403676898 0.04243379897593868 1.1689867895782557e-07 6.932190396661671 -0.6504879461202895 down LIHITIEPLYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIHITIEPLYR 11 0 Q8NI27;A0A0C4DG98 Q8NI27 THOC2 THO complex subunit 2 0 73784000.0 18105000.0 27081000.0 28598000.0 False True 27466608.65279627 22248183.965181258 22945592.765051343 1.0 0.8100084086251491 0.8353995593378559 24.711175453699425 -9.934520457192704 6.590650480277427 1.0000000168459247 0.8227039840248065 0.9848504923917037 0.010365893871385725 2.566788394330156e-09 4.1981315170983805e-10 0.010036734555234707 0.0033455778610339644 1.1627317798991778e-10 9.934520457192704 -0.17729603282111817 LIHITIEPLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIHITIEPLYR 11 0 Q8NI27;A0A0C4DG98 Q8NI27 THOC2 THO complex subunit 2 0 11069400.0 6442500.0 1804700.0 2822200.0 False True 5357224.20114224 1794977.722895099 3412308.9716215413 1.0 0.3350574206904357 0.6369546697138391 22.353054243785248 -10.491855034682006 6.255091734058161 1.0003407725773192 0.4860060452023316 0.7944452466350647 0.12324903580954762 0.0005860855949332571 4.761160736434394e-05 0.11941159097122392 0.039778455260541655 3.222144147341133e-11 10.491855034682006 -0.5143347273749876 LIHITIEPLYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIHITIEPLYR 11 0 Q8NI27;A0A0C4DG98 Q8NI27 THOC2 THO complex subunit 2 0 55277000.0 18105000.0 18221000.0 18951000.0 False True 23437279.402904794 17206985.332453743 15502112.453680689 1.0 0.7341716176460791 0.6614296901610249 24.482301775791875 -13.999999999999998 0.1818501317607603 2.3871961159206885 0.6047374154103382 0.9994960223327578 0.0032668498846406026 12.22922708130547 0.1351992405144615 5.996740607359708 0.053469634866334846 1.0000000000000041e-14 13.999999999999998 -1.7824587005103503 LIHLEIK(ub)PAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIHLEIKPAIR 11 1 Q02750;Q02750-2;P36507;A0A1B0GUL7;G5E9C7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 1 5273600.0 2188500.0 2028600.0 1056500.0 True False 2869144.693464148 1725940.7874208675 947183.5146636104 1.0 0.6015523690222124 0.3301274825285998 21.452189295632007 -8.19549706814766 0.2025292279231255 1.26985858169034 4.0121303694953826e-08 0.9997801129541876 0.004079463720008225 0.08661058510141513 0.04181553267634791 0.10254016363676684 0.11310980900636426 6.37533384905933e-09 8.19549706814766 -1.2698585415690364 down LIHLEIK(ub)PAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIHLEIKPAIR 11 1 Q02750;Q02750-2;P36507;A0A1B0GUL7;G5E9C7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 1 7324600.0 3503000.0 1916300.0 1905300.0 True False 3391799.1824452556 2681488.583372486 1406244.7722252042 1.0 0.790579995788346 0.4146014243718868 21.693619324406054 -6.962099857365949 0.404753188682777 1.0196150574219713 0.17173188556559638 0.9998403256890249 0.003060375155584492 0.07895935563076381 0.01842114136359244 0.004837051864881882 0.03144684040230457 1.0911894103312517e-07 6.962099857365949 -0.847883171856375 down LIHLEIK(ub)PAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIHLEIKPAIR 11 1 Q02750;Q02750-2;P36507;A0A1B0GUL7;G5E9C7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 1 5385400.0 2188500.0 1858500.0 1338400.0 True False 2997647.591988714 1776385.3247623602 1022297.4852132447 1.0 0.5925931151846512 0.3410332448501817 21.515399357154898 -8.665198477263251 0.1785824836296335 1.3823373105672117 1.7507717221117507e-09 0.999777873538208 0.004046680261674334 0.23945898135183555 0.049249428138258715 0.1893126375710389 0.14079082180370284 2.1617303638480646e-09 8.665198477263251 -1.38233730881644 down LIHLEIK(ub)PAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIHLEIKPAIR 11 1 Q02750;Q02750-2;P36507;A0A1B0GUL7;G5E9C7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 1 9011800.0 3503000.0 4260900.0 1247900.0 True False 2912899.709212462 4237945.685977565 1508830.120362315 1.0 1.4548889797250677 0.5179821727436835 21.47402459984033 -6.774686413959468 1.5565659694348306 1.2593468599300492 0.5117592149013626 0.748145520973037 0.1919801328606882 0.25891720362926934 1.2386482708428173 0.0971814722732994 0.23034748559984813 1.680016650647846e-07 6.774686413959468 -0.7475876450286867 LIHLEIKPAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIHLEIKPAIR 11 1 Q02750;Q02750-2;P36507;A0A1B0GUL7;G5E9C7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 0 104820000.0 35469000.0 31185000.0 38166000.0 False True 46500202.482284635 26532319.558177944 34216948.43412335 1.0 0.5705850327917619 0.7358451492154064 25.470733662573107 -10.071142846970469 5.05328038184333 1.0000070191506092 0.6532150910021907 0.8544639052748447 0.06746716001665277 5.335415217268413e-06 9.805283517482604e-07 0.06532611922796096 0.0217749322626735 8.489012108131277e-11 10.071142846970469 -0.3467919281484185 LIHLEIKPAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIHLEIKPAIR 11 1 Q02750;Q02750-2;P36507;A0A1B0GUL7;G5E9C7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 0 117128000.0 36573000.0 45935000.0 34620000.0 False True 35412010.13404805 64277085.0478604 25551983.422262397 1.0 1.815121050867967 0.7215626372391268 25.077735403679217 -6.707105685279267 1.8052066431393945 1.502574836307063 0.7243060881377494 0.45153479545988917 0.34364495180417254 0.3808992088741982 2.417714403349671 0.1515838299676885 0.3864973315002021 1.962882552520939e-07 6.707105685279267 -0.7782687481693136 LIHLEIKPAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIHLEIKPAIR 11 1 Q02750;Q02750-2;P36507;A0A1B0GUL7;G5E9C7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 0 139828000.0 58476000.0 43633000.0 37719000.0 False True 88712367.1682359 35846350.24381496 30263823.11717501 1.0 0.4040738781756914 0.3411454804241904 26.402631905249354 -13.999999999999998 0.3175826864599236 7.023300773066623 0.32831251286064655 0.9996885243096064 0.005239329020621421 17.827657232297927 0.1796134831739343 71.25441410605876 0.02115125544446727 1.0000000000000041e-14 13.999999999999998 -6.694988260205976 LIHLEIKPAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIHLEIKPAIR 11 1 Q02750;Q02750-2;P36507;A0A1B0GUL7;G5E9C7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 0 102813000.0 35469000.0 33425000.0 33919000.0 False True 48582847.81368416 31948172.978306074 25908030.783732887 1.0 0.6576018989423535 0.5332752596778706 25.533943724095998 -13.999999999999998 0.14092838406389052 2.6369683655799685 0.38112193024346896 0.9995992579348613 0.003950668513648298 11.935022884439357 0.11768425687059587 5.369983262187672 0.13610931321232403 1.0000000000000041e-14 13.999999999999998 -2.2558464353364993 LIHLEIKPAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIHLEIKPAIR 11 1 Q02750;Q02750-2;P36507;A0A1B0GUL7;G5E9C7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 0 63709000.0 36573000.0 16266000.0 10870000.0 False True 30412069.958614722 16178371.829451812 13142866.742798574 1.0 0.5319720706767946 0.43215955903967135 24.858140679113493 -13.999999999999998 0.21717486093966915 3.7898080116394994 0.3773025629493282 0.9994952245570631 0.005561383395207159 12.924311037384866 0.14765457801745718 15.440448888759944 0.05628642563490426 1.0000000000000041e-14 13.999999999999998 -3.412505448690171 LIHLEIKPAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIHLEIKPAIR 11 1 Q02750;Q02750-2;P36507;A0A1B0GUL7;G5E9C7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 0 131736000.0 58476000.0 46552000.0 26708000.0 False True 75698334.73428653 43961340.27750318 21847418.047221955 1.0 0.5807438225928566 0.28861160716295736 26.173758227341803 -8.140641914833205 0.23061904569813726 1.218389969727751 6.202531105167623e-20 0.9996591775024191 0.005390067561345375 0.08860247556297221 0.0466663152566769 0.08792733065026856 0.10477346912613772 7.233659886432138e-09 8.140641914833205 -1.218389969727751 down LIHQTNLILQTFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIHQTNLILQTFK 13 0 Q9BUL8;C9J363 Q9BUL8 PDCD10 Programmed cell death protein 10 0 33968200.0 11845000.0 12270000.0 9853200.0 False True 15528909.707143156 10439363.828085393 8833685.382568365 1.0 0.6722534952523667 0.5688541919015055 23.888453205120552 -13.999999999999998 0.16147153697454117 2.6192271444636233 0.46884008022406576 0.9995325739885665 0.003973457616927771 12.019812625512312 0.1270340438128554 6.094970283006587 0.09132516136496707 1.0000000000000041e-14 13.999999999999998 -2.1503870642395575 LIHQTNLILQTFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIHQTNLILQTFK 13 0 Q9BUL8;C9J363 Q9BUL8 PDCD10 Programmed cell death protein 10 0 39686400.0 15933000.0 7480400.0 16273000.0 False True 15427215.636283243 10467362.72977067 12010613.120464355 1.0 0.6784998003886389 0.778534079229217 23.87897436641797 -10.512575881743834 8.985705438886486 1.0000113212188424 0.7285169398089281 0.9075814593187923 0.040838823324451407 9.26268670428776e-06 5.024642060061144e-07 0.0395436671746153 0.013180673551192273 3.072020562122929e-11 10.512575881743834 -0.27149438140991433 LIHQTNLILQTFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIHQTNLILQTFK 13 0 Q9BUL8;C9J363 Q9BUL8 PDCD10 Programmed cell death protein 10 0 46647800.0 9400800.0 16254000.0 20993000.0 False True 14261700.890538912 13353346.706918351 16843724.34844123 1.0 0.936308145108894 1.1810459690411266 23.765642716120425 -6.837590493113867 1.2935780893356945 0.9661000762628813 1.188717219141559 0.9202251581098942 0.029281567576652453 0.17163181612926098 0.5589321421001713 0.01775663176996117 0.040884347676832515 1.4534814948821579e-07 6.837590493113867 0.22261714287867762 LIHQTNLILQTFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIHQTNLILQTFK 13 0 Q9BUL8;C9J363 Q9BUL8 PDCD10 Programmed cell death protein 10 0 39571000.0 11845000.0 10364000.0 17362000.0 False True 16224416.599089004 9906084.210835129 13261453.181614147 1.0 0.6105664354915142 0.8173762736318527 23.951663266643443 -10.057684943894227 4.967659709473145 1.0000058230329032 0.7139713545608063 0.7183449049369268 0.08442976287894483 22954549.697592974 46474523.39395291 964.0350731223213 0.02890255469901137 8.75618756807094e-11 10.057684943894227 -0.2860344684720969 LIHQTNLILQTFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIHQTNLILQTFK 13 0 Q9BUL8;C9J363 Q9BUL8 PDCD10 Programmed cell death protein 10 0 32743000.0 15933000.0 6149000.0 10661000.0 False True 13248995.451579249 6115874.116519068 12890165.809105398 1.0 0.46161040200146425 0.9729164642115505 23.659379641852247 -10.717271875091843 9.974274413257522 1.0004279313246958 0.7172634331065074 0.28962141634635363 0.20873982580107733 0.0019891967288890567 5.638516185739567e-05 0.2023978313459725 0.0673704890848175 1.9174680001150664e-11 10.717271875091843 -0.28316449821818834 LIHQTNLILQTFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIHQTNLILQTFK 13 0 Q9BUL8;C9J363 Q9BUL8 PDCD10 Programmed cell death protein 10 0 55815800.0 9400800.0 27187000.0 19228000.0 False True 12169520.917471817 25674019.55070627 15728701.295940699 1.0 2.1096984610007126 1.2924667620529708 23.536769038212874 -10.04960824350595 4.423168060076822 0.9999590895022574 1.7010826108421662 0.49527219634325204 0.3336334442586393 43677773.07189828 24809401.89081434 17127.93315184135 0.11421160094675133 8.920552561301974e-11 10.04960824350595 0.7011235213399087 LIIAGTSCYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIIAGTSCYSR 11 0 P34896-2;P34896;P34896-3;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 0 22090000.0 6702000.0 8756700.0 6631300.0 False True 8786386.902260331 7450234.493349261 5945156.687921244 1.0 0.8479292542231051 0.6766326994309606 23.06683859819743 -6.969580625470715 0.26802296904332734 1.0436166887965976 0.47580920699725143 0.9999789189987544 0.0006064599531608482 0.0764391108430754 0.009516492203136316 0.0033989143234550542 0.01597528784486523 1.0725545128165603e-07 6.969580625470715 -0.5678074817993461 LIIAGTSCYSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIIAGTSCYSR 11 0 P34896-2;P34896;P34896-3;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 0 22603500.0 5041700.0 10872000.0 6689800.0 False True 7648627.497641683 8931806.656676285 5367558.097756503 1.0 1.167765937016837 0.7017674869656672 22.866769456999485 -6.8093256362816135 1.4172892837919602 1.0915059113833139 0.6937348541676456 0.8580669830323715 0.07260246393145196 0.207729374407292 0.8225142949534313 0.0402800720254471 0.09320820951078376 1.5512234583045094e-07 6.8093256362816135 -0.3977710572156683 LIIAGTSCYSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIIAGTSCYSR 11 0 P34896-2;P34896;P34896-3;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 0 16205800.0 6702000.0 3604300.0 5899500.0 False True 9179910.51473995 3445050.1081737834 4506159.604016388 1.0 0.3752814477485542 0.4908718442059933 23.130048659720323 -9.97216258527984 6.126235072505899 1.0000002862534507 0.4330766459784648 0.9697641483871942 0.047189581747981324 1.8454785993899678e-07 3.0896085475911336e-08 0.045691139204184786 0.015230372018673978 1.066196898168144e-10 9.97216258527984 -0.566923640274986 LIIAGTSCYSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIIAGTSCYSR 11 0 P34896-2;P34896;P34896-3;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 0 15604700.0 5041700.0 10563000.0 0.0 False True 6526580.036764698 9975159.76437675 0.0 1.0 1.5283900156262473 0.0 22.637895779091934 -6.8326755970846715 1.4465522149582504 1.285525843031015 1.8110747399051422e-22 0.8677114536388483 0.23051773970745543 0.1919274163965492 0.8056916571670901 0.1275719986265196 0.2755056781278795 1.470023924527476e-07 6.8326755970846715 -1.285525843031015 down LIICNVTGIAHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIICNVTGIAHR 12 0 Q7KZ85 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 15704600.0 4680300.0 5121300.0 5903000.0 False True 6135918.624089676 4357222.002671052 5292214.185574337 1.0 0.7101173059180668 0.8624974530785093 22.548847918951076 -10.179236825601425 4.682971108669209 1.0000271966268568 0.7863073794998034 0.7239224738028494 0.06220893461593561 1.9898013928203783e-05 3.4874349931835453e-06 0.060242169300805865 0.020077847307204185 6.618554881338785e-11 10.179236825601425 -0.21371981712705335 LIICNVTGIAHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIICNVTGIAHR 12 0 Q7KZ85 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 15726600.0 4252100.0 8024900.0 3449600.0 False True 6450746.570149401 6592793.89617012 2767785.0479866103 1.0 1.0220202924539057 0.42906429788986544 22.621034708266713 -6.898272294190377 0.9720990466513889 1.0258351777166121 0.36895635708537844 0.9856877627468447 0.03283697421300836 0.1126891636634264 0.1846671720441069 0.025414212470972693 0.06557036424624094 1.2639436309233067e-07 6.898272294190377 -0.6568788206312337 down LIICNVTGIAHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIICNVTGIAHR 12 0 Q7KZ85 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 17171200.0 4680300.0 5584500.0 6906400.0 False True 6410733.39035174 5337758.324528058 5275250.561772833 1.0 0.8326283436714859 0.8228778582045188 22.612057980473967 LIICNVTGIAHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIICNVTGIAHR 12 0 Q7KZ85 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 15503900.0 4252100.0 6216800.0 5035000.0 False True 5504427.271421783 5870829.614993592 4118681.6634627287 1.0 1.0665650258427646 0.7482489022693329 22.392161030359162 -6.852113187889169 1.2247964649028467 1.0355969938072127 0.7349916339343276 0.9433325261742901 0.03263337476724642 0.1551461798070322 0.4467977414510415 0.020836617864914288 0.048288421098755384 1.405681121099562e-07 6.852113187889169 -0.30060535987288506 LIIHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIIHLR 6 0 Q08623-3;Q08623;Q08623-4;Q08623-2 Q08623-3 HDHD1 Pseudouridine-5-phosphatase 0 23083600.0 8160200.0 9055300.0 5868100.0 False True 10698101.223489208 7704284.537282944 5260925.302789901 1.0 0.7201543878054816 0.49176252803056203 23.35085142359106 -7.0816912690454155 0.16265496314264818 1.2304742879430064 3.018756696183444e-10 0.9999976723106736 0.0003170459304873291 0.07471730480236723 0.005461628703452344 0.011638293159269978 0.028308469269221582 8.285309399025645e-08 7.0816912690454155 -1.2304742876411308 down LIIHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIIHLR 6 0 Q08623-3;Q08623;Q08623-4;Q08623-2 Q08623-3 HDHD1 Pseudouridine-5-phosphatase 0 19579400.0 10469000.0 2835700.0 6274700.0 False True 10136667.325440887 3968009.797980148 4631167.833034942 1.0 0.3914511220094285 0.45687282460298284 23.273080073618736 -10.207456203880751 5.419474059984509 1.000029182990692 0.4241619733098154 0.9904121715391373 0.02670829824330969 9.41793777369007e-06 1.3772841906863666e-06 0.025861505669271857 0.00862006619178624 6.20217185862789e-11 10.207456203880751 -0.5758672096808766 LIIHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIIHLR 6 0 Q08623-3;Q08623;Q08623-4;Q08623-2 Q08623-3 HDHD1 Pseudouridine-5-phosphatase 0 20389200.0 5906900.0 7762700.0 6719600.0 False True 8961199.152234295 6377385.534748063 5391468.114694691 1.0 0.7116665332851118 0.6016458314454977 23.095260370270548 -13.999999999999998 0.1335174950845115 2.3715325136424688 0.45423740262246914 0.999629992492719 0.0032310046150645783 11.932872264495161 0.11396394154536081 4.282448330156714 0.13129079906966679 1.0000000000000041e-14 13.999999999999998 -1.9172951110199996 LIIHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIIHLR 6 0 Q08623-3;Q08623;Q08623-4;Q08623-2 Q08623-3 HDHD1 Pseudouridine-5-phosphatase 0 29508300.0 8160200.0 6083100.0 15265000.0 False True 11177246.461113228 5814328.527878342 11659721.392543463 1.0 0.520193282675387 1.0431658130746972 23.41406148511395 -6.665471882675718 1.9539758153871931 0.692550936521875 1.0409916431693194 0.258976682776739 0.20402753543743887 0.47155897574045774 3.4666968503054774 0.08420442578173774 0.2262646043117539 2.1603698980638498e-07 6.665471882675718 0.3484407066474443 LIIHLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIIHLR 6 0 Q08623-3;Q08623;Q08623-4;Q08623-2 Q08623-3 HDHD1 Pseudouridine-5-phosphatase 0 16895000.0 10469000.0 3580900.0 2845100.0 False True 8705437.355336942 3561608.980946998 3439997.2557439026 1.0 0.4091246465363999 0.39515501810313797 23.053485349053012 LIINSLYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIINSLYK 8 0 P14625;Q96GW1;A0A1W2PRR1;F8W026 P14625 HSP90B1 Endoplasmin 0 112835000.0 28145000.0 40042000.0 44648000.0 False True 36898367.556567736 34067889.6824935 40028253.253857926 1.0 0.923289888916226 1.084824503211202 25.13705365474814 -6.777592578961364 1.5454169868732923 0.9564279604345066 1.0860047842176133 0.7586988926280609 0.03240799751448016 0.2543463495155588 1.1997005633053313 0.01652010156197522 0.03905697036487985 1.6688120270689917e-07 6.777592578961364 0.12957682378310664 LIINSLYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIINSLYK 8 0 P14625;Q96GW1;A0A1W2PRR1;F8W026 P14625 HSP90B1 Endoplasmin 0 72660600.0 33172000.0 9650600.0 29838000.0 False True 32118973.017434776 13504134.907214174 22022532.6791873 1.0 0.420441055194507 0.6856549450455051 24.93692242860037 -10.416432437883513 6.059585704065706 1.0001300418766141 0.5530480001200169 0.7910904980583595 0.10827311713894165 0.0001902713628665579 1.8324216798514406e-05 0.10486514839106227 0.034944998293423776 3.8332536873963746e-11 10.416432437883513 -0.44708204175659727 LIINSLYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIINSLYK 8 0 P14625;Q96GW1;A0A1W2PRR1;F8W026 P14625 HSP90B1 Endoplasmin 0 97942000.0 18427000.0 67050000.0 12465000.0 False True 27955106.194149442 55084403.635958925 10001287.286396427 1.0 1.9704594664529378 0.35776245015622715 24.736608489610898 -6.743767558624856 1.6729322299630964 1.5748921181811564 0.3560260350608103 0.621701627994016 0.4077294651761539 0.3110520419664739 1.7106892344917974 0.19269981836358877 0.47092123357021265 1.8039830031735188e-07 6.743767558624856 -1.218866083120346 LIINSLYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIINSLYK 8 0 P14625;Q96GW1;A0A1W2PRR1;F8W026 P14625 HSP90B1 Endoplasmin 0 117804000.0 28145000.0 33054000.0 56605000.0 False True 38550967.09002624 31593564.985039067 43236064.816568844 1.0 0.819527170648148 1.121529966177028 25.20026371627103 -6.744824551406645 1.6689670740737277 0.8932293885115405 1.1219043077703263 0.6265260879718499 0.07582376546739324 0.3091059543759112 1.6922912272034993 0.03591507567296711 0.08767222406491605 1.799597779374597e-07 6.744824551406645 0.2286749192587858 LIINSLYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIINSLYK 8 0 P14625;Q96GW1;A0A1W2PRR1;F8W026 P14625 HSP90B1 Endoplasmin 0 59402000.0 33172000.0 15534000.0 10696000.0 False True 27583987.768768426 15450315.258742418 12932484.14728369 1.0 0.5601189859950495 0.468840265435671 24.717327704034645 -13.999999999999998 0.22104415783330567 3.6666471690976414 0.42050090695117065 0.9994989599236875 0.005190610546768104 13.02824759852295 0.14893341050141568 15.173295445518763 0.05017028012799127 1.0000000000000041e-14 13.999999999999998 -3.2461462621464707 LIINSLYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIINSLYK 8 0 P14625;Q96GW1;A0A1W2PRR1;F8W026 P14625 HSP90B1 Endoplasmin 0 58427000.0 18427000.0 22460000.0 17540000.0 False True 23854114.75047366 21210081.25607324 14347899.975598082 1.0 0.889158179959375 0.6014853255165624 24.507734811703347 -6.954654719184757 0.5051673804458241 1.0055119909714685 0.4726143967945867 0.999517741282059 0.0036881754096486905 0.08166878084960626 0.028630863072099784 0.0042843754734604575 0.023735588286542694 1.1100570025372011e-07 6.954654719184757 -0.5328975941768818 LIIWDSYTTNK(ub)VHAIPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIIWDSYTTNKVHAIPLR 18 1 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1 P62873;P62879 GNB1;GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 10052300.0 2280300.0 3552300.0 4219700.0 True False 2989495.382456612 3022310.6867569457 3783085.922220573 1.0 1.010976870709654 1.2654596974529626 21.51147055185231 -6.915950172543603 0.8542336092695058 0.9935244231638853 1.302902683622174 0.9929797342387872 0.010275097472020062 0.1006136481087839 0.11839895559899068 0.008668158857893056 0.025039470160681174 1.213528072930477e-07 6.915950172543603 0.30937826045828865 LIIWDSYTTNK(ub)VHAIPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIIWDSYTTNKVHAIPLR 18 1 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1 P62873;P62879 GNB1;GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 38002900.0 5482800.0 8136100.0 24384000.0 True False 5308751.51513298 11384887.159200985 17997098.895680144 1.0 2.144550771824136 3.3900812355556877 22.339941184646232 -6.97004271771922 0.2571629080347747 0.6379786316801704 4.933470354853282 0.9999827143430148 0.004057968844715097 0.07628883006996305 0.008980491866423157 0.02648503841352958 0.11802490841655841 1.071413914513881e-07 6.97004271771922 4.295491723173111 LIIWDSYTTNK(ub)VHAIPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIIWDSYTTNKVHAIPLR 18 1 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1 P62873;P62879 GNB1;GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 196155000.0 17717000.0 62328000.0 116110000.0 True False 26877984.286196712 51205081.429113306 93160807.60717915 1.0 1.9050938077752306 3.4660637723128005 24.679921611504174 -6.962835126193168 0.3934486639160991 0.9077387471219234 4.519816674633102 0.9998613202144108 0.011994875897975417 0.07870355495846607 0.01750026920248579 0.02012015084354967 0.13111784945573482 1.0893435688456229e-07 6.962835126193168 3.6120779275111783 LIIWDSYTTNK(ub)VHAIPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIIWDSYTTNKVHAIPLR 18 1 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1 P62873;P62879 GNB1;GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 25032900.0 2280300.0 5308600.0 17444000.0 True False 3123388.532790433 5074048.498807347 13324086.470457148 1.0 1.6245332418743934 4.265907468947969 21.5746806133752 -6.943595453681588 0.6252191938637143 0.9711666666838863 5.060467875649874 0.9985979349175722 0.05300263209424004 0.086163963277573 0.04742276368269712 0.053126360754247495 0.22398832679335967 1.138687481992912e-07 6.943595453681588 4.089301208965988 LIIWDSYTTNK(ub)VHAIPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIIWDSYTTNKVHAIPLR 18 1 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1 P62873;P62879 GNB1;GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 31851100.0 5482800.0 8517300.0 17851000.0 True False 4559191.129223543 8471415.614348315 21583561.566301532 1.0 1.8580961785190713 4.734076934821844 22.12034646008051 -6.948936375654108 0.5704006308212576 0.964238576171686 5.7678589743335165 0.9991151538763776 0.04750208959960429 0.08391566674727673 0.037751699123584316 0.050302588141175324 0.23964931286920899 1.1247697411935739e-07 6.948936375654108 4.80362039816183 LIIWDSYTTNK(ub)VHAIPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIIWDSYTTNKVHAIPLR 18 1 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1 P62873;P62879 GNB1;GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 176849000.0 17717000.0 59153000.0 99979000.0 True False 22935005.75428137 55861083.55033403 81783847.87116992 1.0 2.435625442993674 3.5658961130150577 24.451047933596623 -7.475876020166411 0.18395405770937598 9.775971787261281e-18 5.4623777087476535 0.9999676712364061 0.005970084413436571 0.13195453850271294 0.016646780128052326 0.14945324524958706 0.29464891330172155 3.3429045767894274e-08 7.475876020166411 5.4623777087476535 LIK(ub)DDFLQQNGYTPYDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIKDDFLQQNGYTPYDR 17 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 30329300.0 6080300.0 10557000.0 13692000.0 True False 7971332.181708952 8981936.750863684 12275283.182938138 1.0 1.12677988397895 1.5399286973769637 22.92638941917831 -6.949576981158349 0.5634667893656534 0.9946914347011487 1.6918801145838196 0.9991676798081897 0.006650718642101521 0.08365601223989094 0.036668518306754425 0.0070997052507190996 0.03437033854102525 1.1231118740843423e-07 6.949576981158349 0.6971886798826709 LIK(ub)DDFLQQNGYTPYDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIKDDFLQQNGYTPYDR 17 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 59268300.0 11925000.0 8741300.0 38602000.0 True False 11546447.402414994 12231746.6752773 28490978.164822984 1.0 1.0593515259697084 2.4675103234665894 23.46094569738423 -6.9157536892688425 0.8556205205923195 0.9639262278820008 2.673806049134869 0.9929179297888127 0.05707686290465077 0.10073524756661559 0.1190349376044455 0.048102100416638836 0.13872653332939514 1.2140772208585412e-07 6.9157536892688425 1.7098798212528683 up LIK(ub)DDFLQQNGYTPYDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIKDDFLQQNGYTPYDR 17 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 194051000.0 21501000.0 35310000.0 137240000.0 True False 32618588.933652144 29008654.621710822 110114453.84557126 1.0 0.8893289247035145 3.3758190481369263 24.95919103723453 -6.896484666547042 0.9832391627064413 0.8864153997399038 3.6189467425856674 0.9847342744934143 0.1417105775568334 0.11403880005556451 0.1923785985456693 0.10877148883883365 0.27832491575148993 1.2691569532459272e-07 6.896484666547042 2.7325313428457636 up LIK(ub)DDFLQQNGYTPYDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIKDDFLQQNGYTPYDR 17 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 32716200.0 6080300.0 9336900.0 17299000.0 True False 8328351.223929158 8924364.885000642 13213332.484088395 1.0 1.0715644243435611 1.586548421027637 22.9895994807012 -6.9321210954831605 0.7291670604824984 0.9927523094377363 1.6982203830235603 0.9969390521674064 0.014455107761591713 0.09155107567573471 0.07239244572885052 0.013339601636910385 0.04606561291957521 1.1691733418590962e-07 6.9321210954831605 0.705468073585824 LIK(ub)DDFLQQNGYTPYDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIKDDFLQQNGYTPYDR 17 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 44047500.0 11925000.0 9467500.0 22655000.0 True False 9916165.867073553 9416496.698348394 27392055.755115204 1.0 0.9496106483671979 2.762363611329861 23.241350972818505 -6.9005053264179095 0.9580536406879077 0.9256738174669755 2.954616924753918 0.9868164465421131 0.09678310907247796 0.11103474984831802 0.1753234015541029 0.0756923851438161 0.1974457476054094 1.2574614320990277e-07 6.9005053264179095 2.0289431072869424 up LIK(ub)DDFLQQNGYTPYDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIKDDFLQQNGYTPYDR 17 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 151428000.0 21501000.0 29797000.0 100130000.0 True False 27833468.348072663 28138770.756331913 81907367.42056067 1.0 1.0109688955914973 2.9427653929529907 24.73031735932698 -6.908145791365352 0.9082691815751879 0.9366239493976318 3.182763820018368 0.9902028289133512 0.0903944811023885 0.10565695606932778 0.14551281768676713 0.07333527394373268 0.19992986964742088 1.235532599201813e-07 6.908145791365352 2.246139870620736 up LIK(ub)DDIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIKDDIER 8 1 Q6P996;Q6P996-5;Q6P996-4;Q6P996-3;H3BND4;Q86XE2;J3KNK7;Q6P996-2;Q6P474;H3BNL6 Q6P996 PDXDC1;PDXDC2P Pyridoxal-dependent decarboxylase domain-containing protein 1;Putative pyridoxal-dependent decarboxylase domain-containing protein 2 1 11580100.0 3097000.0 3116600.0 5366500.0 True False 4009127.550996742 2943158.470288417 4389852.064939971 1.0 0.7341144508003229 1.0949644303156616 21.934856887102995 -6.709285185181151 1.7978531070894008 0.8364203000987123 1.0940956262783486 0.4616808825322978 0.11205515498833582 0.37650356971835885 2.3718404377430136 0.04960898086951286 0.12613476729150097 1.9530565343480425e-07 6.709285185181151 0.2576753261796363 LIK(ub)DGLIIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIKDGLIIR 9 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 27291100.0 3740900.0 8935600.0 14614600.0 True False 4904356.126927136 7602443.310695993 13102421.385142263 1.0 1.5501409591679396 2.671588491138324 22.225632312605978 -6.959670380045349 0.44005390836011093 0.9599243437410666 3.305532685693061 0.9997577802618599 0.01082562505817556 0.0798190686262754 0.02156790458709011 0.01478660567122659 0.09291800010943126 1.0973107148566121e-07 6.959670380045349 2.345608341951994 LIK(ub)DGLIIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIKDGLIIR 9 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 66896500.0 9302300.0 19163900.0 38430300.0 True False 9007003.578321593 26816145.208418246 28364251.54571262 1.0 2.977254863422103 3.149132927401162 23.10261580392189 -10.350056296820831 0.507981552712252 1.2559703625852034e-21 3.1418502907332826 0.999543850993729 0.020826412243436974 1.703301546848041 0.23961107991774855 2.36688721697405 0.03435319302485021 4.466256931045739e-11 10.350056296820831 3.1418502907332826 LIK(ub)DGLIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIKDGLIIR 9 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 18972400.0 3740900.0 11902200.0 3329300.0 True False 5124011.824021288 11376321.448687939 2542987.909085818 1.0 2.2201981258817396 0.4962884545200169 22.28884237412887 -6.716508372514352 1.7715694843663405 1.7450606176599606 0.49940673996908447 0.4962548846017758 0.5136895860985976 0.3620787210135597 2.218819406277996 0.2303940904411744 0.5808318772698084 1.9208419305846325e-07 6.716508372514352 -1.245653877690876 LIK(ub)DGLIIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIKDGLIIR 9 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 42067900.0 9302300.0 20656300.0 12109300.0 True False 7735274.61176338 20545020.411945477 14641298.642922811 1.0 2.6560169409760506 1.892796232554838 22.883021079356165 -10.048764933212109 4.858455639465669 0.9999695369509141 2.2744065867822183 0.788024657048636 0.3115835495174427 20442745.591218457 42281822.794127055 4145.439240987635 0.10666333478124074 8.937891262810166e-11 10.048764933212109 1.2744370498313042 LIK(ub)EMVQEDQKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIKEMVQEDQKR 12 2 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 3549420.0 864700.0 872860.0 1811860.0 True False 1133630.0737667112 742632.6903816324 1624386.107788366 1.0 0.6550926158072781 1.4329066821516303 20.112518506068348 -6.786155128912826 1.5115924579383324 0.8062643382865481 1.4403331385119662 0.7886521049921057 0.14629303437959507 0.24112906573167373 1.088454771957054 0.07619468162038372 0.17890791946366827 1.63623195903045e-07 6.786155128912826 0.6340688002254181 LIK(ub)EMVQEDQKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIKEMVQEDQKR 12 2 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 12040700.0 4133400.0 4714500.0 3192800.0 True False 6270669.992017017 3873160.6404433707 2561741.6805460476 1.0 0.6176629682911338 0.40852758697353175 22.58018816586353 -10.262699982300553 0.12431759295219158 1.8092404061813385 5.374133944217549e-11 0.9998380765075766 0.003116253710456438 1.9677925751519711 0.06207479611608737 0.7329562259222993 0.2387693720835408 5.461350097631727e-11 10.262699982300553 -1.8092404061275973 LIK(ub)EMVQEDQKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIKEMVQEDQKR 12 2 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 5139670.0 864700.0 2092770.0 2182200.0 True False 1184402.9576388577 2000304.5015350657 1666809.303819744 1.0 1.6888715860037464 1.407299173874555 20.17572856759124 -10.19225929523421 4.78840482680371 0.9999356248621576 1.548085379933636 0.8347627068048289 0.11495145604377112 9.120455471781628e-05 1.5385027124656663e-05 0.11131628315710677 0.03710042288408362 6.423041155649232e-11 10.19225929523421 0.5481497550714785 LIK(ub)GIHQSTIDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIKGIHQSTIDLK 13 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 10092700.0 3380900.0 4365100.0 2346700.0 True False 2811368.149265316 4341584.339895493 2837384.1200851356 1.0 1.5442959119495123 1.009253847037649 21.422840956639817 -10.618416808601358 3.1393015357356076 0.9824659615038251 1.2767748793481273 0.2629678437729761 0.21843000917776043 123052932.66171406 133491562.83752741 17638521.62444418 0.08634204173223578 2.4075936621461055e-11 10.618416808601358 0.29430891784430213 LIK(ub)NNASTDYDLSDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIKNNASTDYDLSDK 15 1 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 1 55366250.0 21818400.0 22618000.0 10929850.0 True False 28604133.689686168 19243482.564273465 9798933.968524441 1.0 0.6727518047928895 0.34257055552979937 24.769720315504543 -7.253110246006922 0.26882636393196685 1.0980230579472645 1.0397518855525726e-15 0.999935889212493 0.0021490125668781287 0.09834323853296217 0.015952496138183427 0.01276112651972076 0.04380887532910355 5.5832844461681566e-08 7.253110246006922 -1.0980230579472634 down LIK(ub)NNASTDYDLSDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIKNNASTDYDLSDK 15 1 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 1 82811500.0 29029600.0 27169800.0 26612100.0 True False 28108071.23799964 38018842.82863527 19641592.664112885 1.0 1.352595221020969 0.6987883479375553 24.744481124303267 -6.760231052857685 1.6116136641339591 1.2047484191422235 0.6963735501940379 0.6919055570600723 0.1483072583789993 0.2825294644064779 1.4463307322861965 0.07260604712095899 0.1744430641685432 1.7368765318169817e-07 6.760231052857685 -0.5083748689481856 LIK(ub)NNASTDYDLSDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIKNNASTDYDLSDK 15 1 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 1 173429000.0 64845300.0 34936700.0 73647000.0 True False 98375060.9264384 28701972.92331698 59090638.16937314 1.0 0.2917606622351102 0.600666852075031 26.5517892883335 -10.499946760159458 6.254002263147692 1.0004130551764439 0.4462137571558764 0.8107919576043121 0.12611042391585323 0.0007268206346559811 5.811479113920888e-05 0.12219262120224371 0.0407019643007714 3.1626653452192504e-11 10.499946760159458 -0.5541992980205674 LIK(ub)NNASTDYDLSDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIKNNASTDYDLSDK 15 1 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 1 60862240.0 21818400.0 16786640.0 22257200.0 True False 29885252.100089826 16044950.738804847 17000507.761422765 1.0 0.5368852397519719 0.5688594395819625 24.832930377027434 -9.970043338848976 5.34418600616861 1.0000014000757826 0.552872339665424 0.996179368192216 0.013053412424952155 17938779.293707144 8.963468921722018 309.06689344719433 0.004468530272647768 1.0714123821743861e-10 9.970043338848976 -0.4471290604103586 LIK(ub)NNASTDYDLSDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIKNNASTDYDLSDK 15 1 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 1 81472800.0 29029600.0 37613900.0 14829300.0 True False 24139398.629333157 37411266.45492541 17930038.067063756 1.0 1.5498010960995876 0.7427707020536936 24.524886399737543 -6.723252848268422 1.7475791770774467 1.3333087964091983 0.7437840781218907 0.527955210266637 0.2312684555920214 0.34897499744868277 2.0845655120666264 0.10500734005214385 0.2626076687572662 1.8912422080381817e-07 6.723252848268422 -0.5895247182873076 LIK(ub)NNASTDYDLSDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIKNNASTDYDLSDK 15 1 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 1 229049900.0 64845300.0 31196600.0 133008000.0 True False 83943519.14195968 29460481.785984598 108801908.777329 1.0 0.3509560009768353 1.2961323267056564 26.322915610425948 -6.721916487334221 1.7525984528094447 0.6059365448138444 1.2948019733351275 0.5214724788136439 0.27305764329059645 0.35160394998717465 2.1116950583719603 0.12366454737294624 0.30972567528500555 1.8970706833827195e-07 6.721916487334221 0.6888654285212831 LIK(ub)SMVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIKSMVK 7 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 3683800.0 1322400.0 1183900.0 1177500.0 True False 1733679.2061398176 1007266.734806055 1055663.5953775686 1.0 0.5809994901241383 0.608915185484685 20.72540554139791 -10.74206086230717 6.879953771292776 1.0068059915130196 0.5949573378045465 0.9964501311656566 0.011396534908053193 0.0011958277115174183 4.483320359378422e-05 0.011091121013085492 0.0036782158252801228 1.8110862680435492e-11 10.74206086230717 -0.4118486537084731 LIK(ub)SMVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIKSMVK 7 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 6803400.0 1810900.0 2205600.0 2786900.0 True False 1753413.9707365436 3086307.582052052 2056927.284792114 1.0 1.760170520801548 1.1730984919254839 20.741735217458974 -10.510338295520564 5.62582899535265 0.9991792256375037 1.4666345063635131 0.45722472981798346 0.2396711521678062 0.0024713925141857025 0.00021510532341340318 0.23244233592664668 0.07735353174268789 3.087889171142515e-11 10.510338295520564 0.4674552807260094 LIK(ub)SMVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIKSMVK 7 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 15204300.0 3227400.0 6456200.0 5520700.0 True False 4896201.75454485 5304040.667479168 4429531.225191227 1.0 1.0832969990576358 0.904687234564948 22.223231576759208 -6.779932669623287 1.536544274296583 1.0471698189051335 0.9032857795395827 0.7670054976630631 0.035223275883866596 0.250684897063334 1.169098320472146 0.01805679785614825 0.042601544121412836 1.659844219649809e-07 6.779932669623287 -0.14388403936555083 LIK(ub)SMVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIKSMVK 7 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 4087900.0 1322400.0 1132900.0 1632600.0 True False 1811327.0165162794 1082844.7320006883 1247013.5044524376 1.0 0.5978184624460142 0.6884529922436731 20.788615602920803 -9.822197545967 13.249644793451022 1.0000000114682193 0.6431357274778567 0.953854978263708 0.03700139184689087 0.0 0.0 0.03582644360237556 0.011942147867458517 1.5059219170936078e-10 9.822197545967 -0.3568642839903625 LIK(ub)SMVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIKSMVK 7 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 6880900.0 1810900.0 3655900.0 1414100.0 True False 1505843.5864724084 3636204.9410606697 1709781.7719403405 1.0 2.4147295069196724 1.1354311877408716 20.52214049289325 -6.62206249889012 2.1086844676235774 1.9373191596510695 1.1403188094595837 0.08993086251076576 0.6080553414901709 0.5798935828165838 4.90240180076884 0.23667451145544774 0.674276142983386 2.38746768007326e-07 6.62206249889012 -0.7970003501914857 LIK(ub)SMVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIKSMVK 7 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 13708600.0 3227400.0 6585600.0 3895600.0 True False 4177932.9215650256 6219105.570792345 3186640.772231466 1.0 1.4885604167294075 0.7627314349120216 21.994357898851657 -6.725364588598425 1.7400831186212757 1.2955188864530574 0.7635112914497845 0.5376809693774577 0.2054644824938273 0.3449919378934949 2.044211887263851 0.09365551562809979 0.2336336662759224 1.8820684366706828e-07 6.725364588598425 -0.5320075950032729 LIKEFSIYMTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIKEFSIYMTK 11 1 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 3881910.0 975310.0 1403900.0 1502700.0 False True 1278640.8549154755 1194443.5923593394 1347215.0189162411 1.0 0.9341509680122789 1.0536305122248724 20.286179665762006 -6.757063935172252 1.6234353653638463 0.9616132151010218 1.054006517554434 0.6789540343966035 0.027685807531748503 0.28785110597544583 1.4944992082467152 0.01345994720891065 0.03244196372911024 1.7495891018500511e-07 6.757063935172252 0.09239330245341215 LIKEFSIYMTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIKEFSIYMTK 11 1 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 4337010.0 975310.0 1124800.0 2236900.0 False True 1335908.463761715 1075102.6167838064 1708590.2904016054 1.0 0.8047726666514867 1.278972576901321 20.349389727284898 -6.794894938401555 1.476545817010683 0.891577684573533 1.2847312377313684 0.8168485233756093 0.08327927071526423 0.22812765024394327 0.982335846005112 0.04438135337218955 0.10355744848572297 1.6036332839421693e-07 6.794894938401555 0.3931535531578354 LILDLSMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LILDLSMK 8 0 P52788;P52788-2 P52788 SMS Spermine synthase 0 30228500.0 8195000.0 12646000.0 9387500.0 False True 12432414.134750912 10389222.49635102 7532056.510312589 1.0 0.8356560828609473 0.6058402196608854 23.567603131322706 -6.966396706003958 0.3332113044612041 1.0269709484421494 0.4069657359388428 0.999939108035782 0.0012614211065372896 0.0774901455568546 0.013205882784455728 0.003316086012744852 0.019994017678192512 1.0804465672099107e-07 6.966396706003958 -0.6200052125033066 LILDLSMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LILDLSMK 8 0 P52788;P52788-2 P52788 SMS Spermine synthase 0 29903600.0 8195000.0 11999000.0 9709600.0 False True 10608589.047600368 11331245.102031283 7942552.428909195 1.0 1.0681199027682553 0.7486907441952214 23.338729453415155 -6.850947340493765 1.2305263570047391 1.0363823566653063 0.7356870884590144 0.9416707078313615 0.033176564154846704 0.15641799436115242 0.45530012841730344 0.021092053253774896 0.04883823753198686 1.4094596892684832e-07 6.850947340493765 -0.3006952682062919 LILDWVPYINGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LILDWVPYINGK 12 0 O14957 O14957 UQCR11 Cytochrome b-c1 complex subunit 10 0 9510100.0 2468600.0 2516800.0 4524700.0 False True 3236358.505956409 2141303.2504095607 4056527.4479871653 1.0 0.6616396936459802 1.2534233894425673 21.625939999748827 -6.751604742772107 1.6437096880888982 0.8014301381471657 1.2547605605832493 0.6559532754226169 0.14219425986404025 0.2972408366775703 1.5805042092432724 0.06832124840418767 0.16559979976950806 1.771720691520082e-07 6.751604742772107 0.45333042243608357 LILDWVPYINGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LILDWVPYINGK 12 0 O14957 O14957 UQCR11 Cytochrome b-c1 complex subunit 10 0 15057200.0 6043400.0 3238300.0 5775500.0 False True 5851555.574989917 4531370.077511412 4262723.288713929 1.0 0.774387258129941 0.7284769381552485 22.480388770429784 -13.999999999999998 0.223809392149747 2.384627431464621 0.7047981876149714 0.999501991666499 0.0026481462897755483 13.106140727508176 0.14984081981790048 8.036742869430054 0.02478460721389167 1.0000000000000041e-14 13.999999999999998 -1.6798292438496496 LILDWVPYINGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LILDWVPYINGK 12 0 O14957 O14957 UQCR11 Cytochrome b-c1 complex subunit 10 0 14439200.0 2468600.0 3655300.0 8315300.0 False True 3381308.1314066006 3493796.7595393304 6351397.398979156 1.0 1.0332677838756845 1.87838468194764 21.689150061271718 -6.9152019259786535 0.8595604906108295 0.9779371687577197 2.000683747952576 0.9927406476814817 0.03463115258981599 0.10107875498219882 0.12085380077574162 0.029103184713600096 0.08355083984278737 1.2156206642763174e-07 6.9152019259786535 1.0227465791948562 LILDWVPYINGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LILDWVPYINGK 12 0 O14957 O14957 UQCR11 Cytochrome b-c1 complex subunit 10 0 12603700.0 6043400.0 3132500.0 3427800.0 False True 5025354.868014447 3115624.6007474344 4144537.1316435095 1.0 0.619981012799289 0.8247252662737915 22.26079404586406 -10.062553377001942 5.033119813358189 1.0000053114316214 0.7223531395351824 0.7103035565655283 0.08358649146797904 4.981945214424217e-06 9.278046511675081e-07 0.08093382054410764 0.026977424117940844 8.658578984780628e-11 10.062553377001942 -0.277652171896439 LILEQMQK(ub)DPQALSEHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LILEQMQKDPQALSEHLK 18 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 22503600.0 10126000.0 9648000.0 2729600.0 True False 8420217.657860514 9596024.309021937 3300346.739755566 1.0 1.139640885656177 0.39195503891453426 23.005426095948078 -6.858430125062968 1.1936505064545753 1.075467604257465 0.3568191774380051 0.9517075744915854 0.07133131383210341 0.14842206274097194 0.4027344410690988 0.046638577690368624 0.1086826189659126 1.385383066415638e-07 6.858430125062968 -0.7186484268194597 down LILEVHQFSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LILEVHQFSR 10 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 16255100.0 5005000.0 6178400.0 5071700.0 False True 6561603.4684889475 5256606.803214567 4546929.135181672 1.0 0.8011161949146396 0.6929600602989152 22.645616980716316 -13.999999999998023 0.07421802420025006 2.114316353252811 0.3323568114666131 0.999909403420839 0.001210319590799893 12.316878423724345 0.07492825197438314 2.319228826224586 0.3300372462704248 1.0000000000045524e-14 13.999999999998023 -1.781959541786198 LILEVHQFSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LILEVHQFSR 10 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 9677700.0 3190200.0 1627700.0 4859800.0 False True 3088928.8472271916 2277649.098343366 3586872.58912509 1.0 0.7373588745457574 1.1612027231850557 21.558675208520626 -6.739097077234469 1.6898318715163658 0.8435629131350302 1.1614090517349054 0.6008815215340646 0.11035399587342107 0.3194894874930161 1.79095159982565 0.051667710926646154 0.12692213610114597 1.823488055041707e-07 6.739097077234469 0.3178461385998752 LILEVHQFSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LILEVHQFSR 10 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 29389600.0 7338600.0 11144000.0 10907000.0 False True 11133192.723524477 9155266.13153059 8751226.669292081 1.0 0.8223396790918277 0.7860482510826123 23.408364045379383 -13.999999998395342 0.22326626946067177 2.0876885537338876 0.7672331800630481 0.9995013714107788 0.0020875193976242026 13.090485040976464 0.14966174685228092 6.288539921964484 0.01966054489340978 1.000000003694861e-14 13.999999998395342 -1.3204553736708395 LILEVHQFSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LILEVHQFSR 10 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 18327400.0 5005000.0 3828900.0 9493500.0 False True 6855483.7550393045 3659726.537520903 7251330.824769839 1.0 0.5338392837457641 1.0577416684037149 22.708827042239207 -6.672016355068613 1.930533760852079 0.7029651115784844 1.0556298992953856 0.2879111569610311 0.19792391534497136 0.4564824705278125 3.281922815044171 0.08248644723374722 0.21978054581508086 2.1280589040371025e-07 6.672016355068613 0.35266478771690124 LILEVHQFSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LILEVHQFSR 10 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 8172300.0 3190200.0 2367900.0 2614200.0 False True 2652792.649822893 2355143.6527086487 3160817.1333048786 1.0 0.8877978657193143 1.1915055379529578 21.339080483954902 -6.806719388178239 1.4285743276596545 0.9386096218540585 1.19641436802507 0.8510050104870275 0.048400062829378525 0.21131522748021908 0.8506086479043389 0.02664642033602011 0.06172693946190515 1.560560506153697e-07 6.806719388178239 0.25780474617101157 LILEVHQFSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LILEVHQFSR 10 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 36855600.0 7338600.0 17362000.0 12155000.0 False True 9499962.365432592 16395789.437575422 9942914.720832068 1.0 1.725879409505305 1.0466267484396825 23.179490367471832 -10.595219899350816 5.633752483520338 0.9979749610155644 1.386253078970611 0.30125713153293754 0.27730373767307126 0.007085439118212692 0.0005090819721773424 0.2697192052989762 0.08949939648740605 2.5396864428046393e-11 10.595219899350816 0.3882781179550465 LILEYVK(ub)ASEAGEVPFNHEILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LILEYVKASEAGEVPFNHEILR 22 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 129314200.0 59742300.0 36862600.0 32709300.0 True False 57845813.38778168 51582028.41591948 24141753.072033726 1.0 0.8917158458837533 0.4173465918820151 25.785709211733515 -6.942791857161411 0.6330612386439702 1.0051765548409202 0.2781856287653341 0.9985071504223191 0.009776583854958557 0.08651584032389006 0.04898135061774649 0.009731633044506287 0.0403527531479506 1.1407964021735804e-07 6.942791857161411 -0.726990926075586 down LILEYVK(ub)ASEAGEVPFNHEILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LILEYVKASEAGEVPFNHEILR 22 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 344755400.0 101613000.0 110313000.0 132829400.0 True False 154154349.9053623 90626783.27059713 106575610.86880575 1.0 0.5878963735128738 0.69135649389222 27.19980035888036 -9.958535984958193 6.832806867271899 1.0000000275822982 0.63962643370255 0.9417826970167269 0.04223741727605966 1.7746212140012538e-08 2.6756252038011364e-09 0.040896206471242286 0.01363206780808181 1.1001806822767885e-10 9.958535984958193 -0.3603735938797482 LILEYVK(ub)ASEAGEVPFNHEILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LILEYVKASEAGEVPFNHEILR 22 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 108417700.0 59742300.0 36772400.0 11903000.0 True False 49678369.4826388 36574299.78245005 14391862.266746225 1.0 0.7362218237704389 0.28970077755421864 25.56611448716779 -7.000579672119168 0.3963859873096095 1.026169645650382 4.2424108877665475e-11 0.9998683903735436 0.003363162635539146 0.07441132150832247 0.01732421452091344 0.005698821962569284 0.035521146337279624 9.986661459946739e-08 7.000579672119168 -1.0261696456079579 down LILEYVK(ub)ASEAGEVPFNHEILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LILEYVKASEAGEVPFNHEILR 22 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 267393000.0 101613000.0 93302000.0 72478000.0 True False 131540031.59167978 88109661.68095046 59287747.68708078 1.0 0.6698315380861107 0.45072018738081915 26.97092668097281 -8.315370781352408 0.14155013099253336 1.4165737440037436 1.0783951289336694e-10 0.9999363305822697 0.001801441647063379 0.09360199692731098 0.030756636082914107 0.14060333587896892 0.13816401841325493 4.837591791128223e-09 8.315370781352408 -1.416573743895904 down LILFPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LILFPR 6 0 P26373 P26373 RPL13 60S ribosomal protein L13 0 16203300.0 4001700.0 5010000.0 7191600.0 False True 5246267.452517925 4262527.528827046 6447482.218698369 1.0 0.8124876528704733 1.228965598313888 22.322859926790933 -6.784345800199762 1.519277020612837 0.8944228204237552 1.2327049074339338 0.7823437170414572 0.07945438724005367 0.24388869981123878 1.1121848290626544 0.04118255522897918 0.09681279511977448 1.6430629390256132e-07 6.784345800199762 0.3382820870101786 LILFPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LILFPR 6 0 P26373 P26373 RPL13 60S ribosomal protein L13 0 10120300.0 4791700.0 1836400.0 3492200.0 False True 4639590.10634397 2569684.096699487 2577488.0562456604 1.0 0.5538601552722976 0.5555421916951926 22.145565922593804 -9.939470106039213 5.103303116282143 1.0000017236379095 0.5547011734771328 0.999989298244259 0.0006866885171525849 196270.45221982247 382267.0274359016 2.365747494012204 0.00023507170321708455 1.1495553684878372e-10 9.939470106039213 -0.44530055016077674 LILFPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LILFPR 6 0 P26373 P26373 RPL13 60S ribosomal protein L13 0 30966800.0 5820300.0 22187000.0 2959500.0 False True 8829820.620926265 18227556.5021778 2374553.5278050695 1.0 2.06431787062348 0.268924322446312 23.07395269893871 -6.746069705132752 1.6642480628398186 1.6287468502305635 0.2663507775748197 0.6320218851748443 0.4471718541781503 0.3069106369379627 1.6711820031047524 0.21236620386273306 0.5177419840350046 1.794445591612441e-07 6.746069705132752 -1.3623960726557438 LILFPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LILFPR 6 0 P26373 P26373 RPL13 60S ribosomal protein L13 0 17534000.0 4001700.0 6971500.0 6560800.0 False True 5481236.631876279 6663476.078332419 5011274.163917411 1.0 1.2156884524161564 0.9142597739302499 22.386069988313825 -6.7146225605283165 1.7787105832888677 1.131970778685708 0.9148668525775528 0.4870072662326962 0.09082739283299261 0.3658721072828796 2.259167616861345 0.040593209787411454 0.10255256295962283 1.9292008272249884e-07 6.7146225605283165 -0.2171039261081552 LILFPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LILFPR 6 0 P26373 P26373 RPL13 60S ribosomal protein L13 0 10054900.0 4791700.0 3479500.0 1783700.0 False True 3984510.858302412 3460755.242873327 2156663.4231030215 1.0 0.8685520923257743 0.5412617758612059 21.92597119802808 -6.955548918484263 0.49419363516358145 1.006897692743279 0.38893862032059046 0.9995678243691076 0.0040098301050627335 0.08133125687566499 0.02731175821447138 0.004755485166991947 0.026994702226667125 1.1077737798460888e-07 6.955548918484263 -0.6179590724226884 LILFPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LILFPR 6 0 P26373 P26373 RPL13 60S ribosomal protein L13 0 15383700.0 5820300.0 4668200.0 4895200.0 False True 7534493.085265214 4408410.566322406 4004323.8289935985 1.0 0.5850971679758639 0.5314655921344769 22.84507902103116 -13.999999999999998 0.2884227891509934 4.543627911355269 0.5166171669963329 0.9996239333146066 0.004060309302672769 15.872528176924249 0.17027463822324537 33.34271026095935 0.020400541288416386 1.0000000000000041e-14 13.999999999999998 -4.027010744358936 LILIESR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LILIESR 7 0 P62277 P62277 RPS13 40S ribosomal protein S13 0 24760400.0 7940800.0 7555800.0 9263800.0 False True 10410465.69881659 6428504.092277723 8305270.840644341 1.0 0.6175039886072036 0.797780914026588 23.311531271402718 -10.106853292860427 4.827335686396885 1.00001287576869 0.707642451316826 0.778103561749246 0.07359774662500133 1.1302899862732509e-05 2.0912355817474653e-06 0.07126418817069011 0.023753570581276553 7.81891887496436e-11 10.106853292860427 -0.2923704244518639 LILIESR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LILIESR 7 0 P62277 P62277 RPS13 40S ribosomal protein S13 0 19733400.0 7404000.0 4815900.0 7513500.0 False True 7168964.072744704 6738913.984586722 5545488.949831558 1.0 0.9400122411279803 0.7735411830161979 22.773333231474567 -6.953188212085274 0.5226706596078206 1.0027715186118396 0.7033188804618713 0.9994283185950948 0.0022905015773561927 0.0822302079695704 0.030855197255328416 0.0025839518131809654 0.013754368986731763 1.113811731556146e-07 6.953188212085274 -0.29945263814996825 LILIESR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LILIESR 7 0 P62277 P62277 RPS13 40S ribosomal protein S13 0 48907600.0 7295600.0 31594000.0 10018000.0 False True 11067958.579803372 25955803.854951296 8037937.908954613 1.0 2.345130194317407 0.7262349105301233 23.39988581420951 -6.686201759923667 1.880684509058848 1.8463243262728033 0.7321799885896398 0.352433164954828 0.5693448640133992 0.4248416196253246 2.910513315993349 0.2424981752596336 0.634342008440961 2.0596728300158284e-07 6.686201759923667 -1.1141443376831635 LILIESR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LILIESR 7 0 P62277 P62277 RPS13 40S ribosomal protein S13 0 37768800.0 7940800.0 12459000.0 17369000.0 False True 10876728.35205117 11908520.183596587 13266799.925783675 1.0 1.0948623334286764 1.2197417731115605 23.37474133292561 -6.967335665510721 0.3154033060620066 0.9819485460826658 1.3366564281069768 0.999953509781501 0.0006135430505761793 0.07717708226607077 0.012110288894105304 0.0019294795797003951 0.011030404820820102 1.0781131282164558e-07 6.967335665510721 0.354707882024311 LILIESR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LILIESR 7 0 P62277 P62277 RPS13 40S ribosomal protein S13 0 14896300.0 7404000.0 4687400.0 2804900.0 False True 6156754.052814471 4662148.045823953 3391391.621607707 1.0 0.7572412355326619 0.5508408477121775 22.553738506908843 -6.973007313630641 0.17177815116977901 1.178050804216387 0.12449449110388436 0.9999973392773157 0.00029937632952224344 0.07533841635710765 0.005368423554249012 0.008557732717784906 0.023772713702406308 1.0641250979334124e-07 6.973007313630641 -1.0535563131125028 LILIESR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LILIESR 7 0 P62277 P62277 RPS13 40S ribosomal protein S13 0 29805100.0 7295600.0 14843000.0 7666500.0 False True 9444298.017775856 14016974.001954375 6271275.664932872 1.0 1.4841731990638083 0.6640277184317153 23.17101213630196 -6.746751886480031 1.661962497573969 1.2858085375178137 0.6628027967067986 0.6348337079975868 0.2034282803449819 0.3057465480942446 1.6605408018899714 0.09673749304776609 0.23565011030827782 1.791629123893179e-07 6.746751886480031 -0.623005740811015 LILISTNGSFIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LILISTNGSFIR 12 0 Q6UXN9 Q6UXN9 WDR82 WD repeat-containing protein 82 0 10272700.0 2796900.0 6148900.0 1326900.0 False True 3666762.9852181314 5231508.088224475 1189605.1165235627 1.0 1.4267374546198706 0.3244292367189352 21.8060755844598 -6.801741240401857 1.448832145361397 1.2349332025365762 0.3085575791077262 0.8371916424119373 0.18311471381923694 0.21828374697263844 0.9044211981252278 0.09942121586566889 0.23097214835248814 1.5785515158041466e-07 6.801741240401857 -0.92637562342885 down LILISTNGSFIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LILISTNGSFIR 12 0 Q6UXN9 Q6UXN9 WDR82 WD repeat-containing protein 82 0 25066700.0 11722000.0 7331900.0 6012800.0 False True 11349891.526298402 10259565.90535339 4437867.299866535 1.0 0.9039351505326143 0.39100526111493855 23.436175173602688 -6.938351687316471 0.6747270236835161 1.005954678086582 0.2591447664582313 0.9979398874382834 0.012133811093864693 0.08852682241002424 0.05809553795963508 0.01166872137777976 0.04447704294815641 1.1525195810314631e-07 6.938351687316471 -0.7468099116283506 down LILISTNGSFIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LILISTNGSFIR 12 0 Q6UXN9 Q6UXN9 WDR82 WD repeat-containing protein 82 0 90691000.0 25070000.0 32762000.0 32859000.0 False True 38033022.862502135 26915365.129325625 26364404.247388683 1.0 0.707684088814888 0.6931977072319991 25.180749273057184 LILISTNGSFIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LILISTNGSFIR 12 0 Q6UXN9 Q6UXN9 WDR82 WD repeat-containing protein 82 0 25321300.0 2796900.0 7342400.0 15182000.0 False True 3830989.5133805075 7017988.489930138 11596324.283104803 1.0 1.8318996868611597 3.026978863450889 21.869285645982693 -6.9659653452618135 0.3410784396558462 0.8719852107538953 4.026674131537327 0.99993168411385 0.006876154637730332 0.07763488355298512 0.013713272738728261 0.016815158094007267 0.10335798596269008 1.0815202482860181e-07 6.9659653452618135 3.1546889207834314 LILISTNGSFIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LILISTNGSFIR 12 0 Q6UXN9 Q6UXN9 WDR82 WD repeat-containing protein 82 0 22583700.0 11722000.0 6092800.0 4768900.0 False True 9747362.372648729 6059976.877073889 5766054.941097716 1.0 0.6217042770543025 0.5915502800303565 23.216580449036964 -13.999999999999998 0.358542622690104 5.905005768966846 0.587843443856481 0.9997706410844543 0.002814555050367603 21.540651826712235 0.19340243744658608 80.79307262150787 0.008743099444035358 1.0000000000000041e-14 13.999999999999998 -5.317162325110365 LILISTNGSFIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LILISTNGSFIR 12 0 Q6UXN9 Q6UXN9 WDR82 WD repeat-containing protein 82 0 88752000.0 25070000.0 32244000.0 31438000.0 False True 32453609.203580342 30449593.05524605 25716606.581120417 1.0 0.9382498218992171 0.7924112976094909 24.951875595149634 -6.956668829302758 0.48008285172895904 1.0034978065380133 0.7210820578413845 0.9996260050054979 0.0016831458547978866 0.08091322775363813 0.025696389766787658 0.0020566271644926345 0.01203040835109227 1.1049208547119205e-07 6.956668829302758 -0.2824157486966289 LILK(ub)NENVDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LILKNENVDR 10 1 Q8NBU5 Q8NBU5 ATAD1 ATPase family AAA domain-containing protein 1 1 4204200.0 1160300.0 1861500.0 1182400.0 True False 964840.8600054859 1851471.730021182 1429634.373200097 1.0 1.9189400104911134 1.481730752149083 19.87993147960087 -10.161784402759963 4.67401273593394 0.9999253097886918 1.7003353812427227 0.7738145272918037 0.17848993240765818 0.00015740799718510644 2.822868804123638e-05 0.17284286870125093 0.05760737795633201 6.88994249557268e-11 10.161784402759963 0.7004100714540309 LILK(ub)NENVDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LILKNENVDR 10 1 Q8NBU5 Q8NBU5 ATAD1 ATPase family AAA domain-containing protein 1 1 12118800.0 1856600.0 2802200.0 7460000.0 True False 2403405.2990573333 2646255.1066682306 6102356.546063951 1.0 1.1010440509996995 2.5390459730023167 21.196648527669126 -6.921081160353756 0.8166761664294647 0.9694911930705676 2.7767969726004975 0.9944758719849462 0.05224329932325735 0.09753966792543428 0.10235095841610498 0.04527258845722353 0.13704509469646572 1.1992751633181982e-07 6.921081160353756 1.8073057795299299 up LILLITQVTASEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LILLITQVTASEK 13 0 Q15061 Q15061 WDR43 WD repeat-containing protein 43 0 8919900.0 2727500.0 2889600.0 3302800.0 False True 3530802.517062843 2728791.2198374555 2701724.289589817 1.0 0.7728529722776584 0.7651870294454451 21.751564700639303 LILPHVDIQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LILPHVDIQLK 11 0 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 48415000.0 18138000.0 18825000.0 11452000.0 False True 23779093.648641832 16016383.379275275 10267056.895340903 1.0 0.6735489424421384 0.4317682182107608 24.50319039134182 -7.703455097516472 0.16920867498071293 1.2765768412342555 9.22893223437865e-10 0.9999560824211272 0.0015430046632276425 0.13321094796503147 0.020786022459950135 0.0544184149351581 0.08542676373744805 1.979451669707696e-08 7.703455097516472 -1.2765768403113622 down LILPHVDIQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LILPHVDIQLK 11 0 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 88263600.0 46447600.0 22469000.0 19347000.0 False True 44973146.36213078 31440988.874287058 14279440.302441083 1.0 0.6991058313136314 0.3175103691314102 25.422560484003533 -7.098469186037414 0.32560466796189225 1.0534556198214373 8.334115806800888e-16 0.9999349439434622 0.0022525403114254964 0.07619059149957641 0.01409758216649598 0.006728193692955041 0.033876742435064486 7.971330465852032e-08 7.098469186037414 -1.0534556198214364 down LILPHVDIQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LILPHVDIQLK 11 0 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 642850000.0 182270000.0 235810000.0 224770000.0 False True 276516915.7219091 193727863.10806072 180344110.97980922 1.0 0.7006004048695933 0.652199199130298 28.042792498081994 -13.999999999446292 0.256454106718817 3.151827350577243 0.633898701532727 0.9995551847809396 0.0032441793436659865 14.263206840739391 0.1602453991686979 15.872068094604732 0.02156304447257718 1.0000000012749601e-14 13.999999999446292 -2.5179286490445163 LILPHVDIQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LILPHVDIQLK 11 0 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 122375800.0 18138000.0 45094000.0 59143800.0 False True 24844108.761019524 43101597.974083334 45175252.54479616 1.0 1.7348820353624381 1.8183486869803218 24.566400452864713 -11.216680116063987 0.38213122112183967 4.919865450100133e-12 1.8269938841477193 0.9995366770708398 0.007914337671379333 3.2572247003400956 0.1907895481101716 2.79796564866996 0.02243570206321285 6.0718339191273765e-12 11.216680116063987 1.8269938841427995 LILPHVDIQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LILPHVDIQLK 11 0 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 89326600.0 46447600.0 18315000.0 24564000.0 False True 38623237.37756684 18216333.45975713 29700218.82889649 1.0 0.4716418067621009 0.7689727957953877 25.20296575943781 -10.167799674086766 5.552094030263328 1.0000090986672898 0.6203073012787083 0.6849716093139526 0.12138486797491167 1.3671378193783262e-05 2.049180951573502e-06 0.1175332076103035 0.0391767976790142 6.795169994200789e-11 10.167799674086766 -0.37970179738858156 LILPHVDIQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LILPHVDIQLK 11 0 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 513180000.0 182270000.0 197010000.0 133900000.0 False True 235952108.07884273 186046220.31429178 109531573.93002191 1.0 0.7884914520540116 0.4642110419010211 27.813918820174443 -6.964891124650095 0.35991693287667487 1.0279697703010655 0.21362146504485194 0.9999108817604364 0.002080093858645748 0.07799793493659543 0.014990402079661872 0.004351437490734602 0.027699007117745665 1.0841986828803533e-07 6.964891124650095 -0.8143483052562136 down LILQLCIGNHDLFMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LILQLCIGNHDLFMR 15 0 A0A5K1VW66;P35240-10;P35240-4;P35240-6;P35240-5;P35240-8;P35240-3;P35240;P35240-2 A0A5K1VW66 NF2 Merlin 0 21302000.0 0.0 11269000.0 10033000.0 False True 0.0 9257958.904901132 8049973.152379887 0.0 LILQLCIGNHDLFMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LILQLCIGNHDLFMR 15 0 A0A5K1VW66;P35240-10;P35240-4;P35240-6;P35240-5;P35240-8;P35240-3;P35240;P35240-2 A0A5K1VW66 NF2 Merlin 0 8103600.0 0.0 4760300.0 3343300.0 False True 0.0 4495385.120359996 2734853.705154906 0.0 LILTGAESK(ub)SNGEEGYGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LILTGAESKSNGEEGYGR 18 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5GY68;Q9UJX4-2 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 33069700.0 9743100.0 9502600.0 13824000.0 True False 12773298.452314608 8084849.1208446855 12393625.089171553 1.0 0.6329492065833361 0.9702760125303221 23.60662778489265 -10.422571204108898 8.480521496320423 1.0000025154561667 0.8016126105007759 0.3156189809840648 0.13771309185549233 6.549674502887829e-06 4.4610427069351265e-07 0.1333418183941802 0.04444670927592119 3.779451667814566e-11 10.422571204108898 -0.19838990495539077 LILTGAESK(ub)SNGEEGYGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LILTGAESKSNGEEGYGR 18 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5GY68;Q9UJX4-2 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 47445300.0 7668900.0 8075400.0 31701000.0 True False 7425454.967243618 11299949.332654662 23397557.0903853 1.0 1.5217854505215973 3.1509930628628724 22.824047993739548 -6.950548383120888 0.5527891919301967 0.9778321653949038 3.7718513934713975 0.9992436270979516 0.025195122861563377 0.08326626091020396 0.035056625618155 0.027249225386117105 0.1352292676488015 1.120602577048182e-07 6.950548383120888 2.7940192280764937 LILTGAESK(ub)SNGEEGYGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LILTGAESKSNGEEGYGR 18 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5GY68;Q9UJX4-2 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 210958000.0 27447000.0 54801000.0 128710000.0 True False 41639105.64447935 45021333.387832664 103270412.08440296 1.0 1.08122719474888 2.480130408326743 25.311435745910078 -6.9188290427318995 0.8333805963082969 0.9678123021017065 2.6997391976673937 0.9938491252179322 0.053284003683145335 0.09886544601875841 0.1092255094040498 0.04562723504001011 0.13517907269303747 1.205510388501885e-07 6.9188290427318995 1.731926895565687 up LILTGAESK(ub)SNGEEGYGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LILTGAESKSNGEEGYGR 18 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5GY68;Q9UJX4-2 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 46586100.0 9743100.0 10829000.0 26014000.0 True False 13345387.3673773 10350538.973285759 19870028.975147445 1.0 0.7755892495550616 1.488906123753259 23.66983784641554 -6.822131106499144 1.3625813199495105 0.8792974184139684 1.5052082086975704 0.889226115781764 0.09911881767626392 0.19072521284967073 0.6952023950194722 0.057154401618545084 0.13166586780637884 1.5061523144588015e-07 6.822131106499144 0.6259107902836021 LILTGAESK(ub)SNGEEGYGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LILTGAESKSNGEEGYGR 18 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5GY68;Q9UJX4-2 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 46952900.0 7668900.0 15750000.0 23534000.0 True False 6377030.13987423 15665151.623869784 28454850.591078367 1.0 2.456496406676657 4.462085009314314 22.604453269173824 -6.9666401199108465 0.3286898427293595 0.7518925161242247 6.232216237983901 0.9999430703764476 0.010708887229393919 0.07740873193207079 0.012920880221360988 0.029402869649116585 0.17511784500573452 1.0798411668588828e-07 6.9666401199108465 5.480323721859676 LILTGAESK(ub)SNGEEGYGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LILTGAESKSNGEEGYGR 18 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5GY68;Q9UJX4-2 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 193816000.0 27447000.0 47939000.0 118430000.0 True False 35530682.56125531 45271152.50823219 96876955.19441739 1.0 1.2741424944534683 2.726571746191489 25.082562068002527 -6.938521922493357 0.6731719934575383 0.9832051974155419 3.101784755902316 0.9979638485669261 0.0341861876061342 0.08844742698985161 0.05772879135381808 0.03291624114385863 0.12584352539193958 1.1520679038061534e-07 6.938521922493357 2.118579558486774 up LIMGIGHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIMGIGHR 8 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 61173700.0 23641000.0 9470700.0 28062000.0 False True 30993579.939769655 8057708.476499464 25158413.429711536 1.0 0.25997992139527426 0.8117298317458745 24.885466068476124 -10.111752079289774 7.048493425522321 1.0000002545916566 0.5358548765721912 0.48547579857992795 0.22525095766422246 9.012068293815524e-07 1.1342575607948806e-07 0.21809842218092224 0.07269943397923379 7.73121802324242e-11 10.111752079289774 -0.4641453780194654 LIMGIGHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIMGIGHR 8 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 27287900.0 9146600.0 1920300.0 16221000.0 False True 8856246.189595722 2687085.8042322095 11972233.480430907 1.0 0.30341137166997295 1.3518406358775157 23.078263896634713 -6.727599839759299 1.7320535223220301 0.5796714570099025 1.3509379079404165 0.5480364299106211 0.292889511697055 0.34077373866628036 2.001714025228036 0.13406809210344484 0.33357954551201663 1.8724065868445025e-07 6.727599839759299 0.7712664509305139 LIMGIGHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIMGIGHR 8 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 41958000.0 23641000.0 11503000.0 6814000.0 False True 32381716.574002817 10994759.42466583 5204673.538735096 1.0 0.3395360279786035 0.16072877195502328 24.948676129999015 -13.999999999998352 0.18337283459986387 4.463231076422962 0.02353135089201147 0.9994944564943797 0.008115692903295932 12.250249507368512 0.13577447574786358 15.128567399257031 0.12977344812685457 1.0000000000037957e-14 13.999999999998352 -4.43969972553095 LIMGIGHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIMGIGHR 8 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 19573200.0 9146600.0 6427200.0 3999400.0 False True 7605803.163083853 6392575.397900691 4835656.04886372 1.0 0.8404865680626888 0.6357850637437549 22.85866917206899 -6.96772034423723 0.307806177953677 1.032364207750156 0.4374211440883437 0.9999587434598766 0.0009574850252109146 0.07704955899852926 0.011664164239920151 0.003271411135796308 0.01821265034156892 1.0771586063810563e-07 6.96772034423723 -0.5949430636618123 LIMGIGHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIMGIGHR 8 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 36346500.0 8326500.0 15798000.0 12222000.0 False True 10778818.389852876 14918827.412441896 9997721.408310123 1.0 1.3840874642146679 0.9275340808897872 23.36169569791107 -6.683653326001215 1.88912636772914 1.2422217349739275 0.9292296409845017 0.3407843082780635 0.1626580985946511 0.4304810078600487 2.9733980548356658 0.06901390738418535 0.1811574871949209 2.0717944913521387e-07 6.683653326001215 -0.31299209398942585 LIMK(ub)SQQESWDLEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIMKSQQESWDLEEK 15 1 B3KVZ3;Q9H3R5;H0Y9E6 B3KVZ3 CENPH Centromere protein H 1 19968300.0 4208100.0 5099200.0 10661000.0 True False 6383995.353318523 4189207.9197685556 8553848.677117703 1.0 0.6562047257116072 1.3398895524996348 22.606028170798787 -6.769984782478279 1.5744234271219142 0.8028028509268015 1.3437399556787877 0.7305188308123423 0.14489282827629607 0.26646257672120033 1.3035208232437885 0.07253837996554816 0.17268007170014382 1.6983031593482406e-07 6.769984782478279 0.5409371047519862 LIMK(ub)SQQESWDLEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIMKSQQESWDLEEK 15 1 B3KVZ3;Q9H3R5;H0Y9E6 B3KVZ3 CENPH Centromere protein H 1 20739900.0 4208100.0 5311800.0 11220000.0 True False 5447468.404052116 5016193.660552532 9178075.12692193 1.0 0.9208302441591439 1.684833108916206 22.377154492891236 -6.881330394439315 1.0724009472736717 0.9500193190824984 1.740367245370781 0.9747407305176884 0.054516737778030275 0.1264558947992157 0.2652469450354763 0.039113587800126866 0.09491062412192089 1.314224640526736e-07 6.881330394439315 0.7903479262882827 LIMQLIPQQLLTTLGPLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIMQLIPQQLLTTLGPLFR 19 0 A0A0C4DGR2;M0QY25;Q86YD1-2;Q86YD1;M0QYQ4;M0QYH7;M0QZQ2;Q71SY5-5;Q71SY5;Q71SY5-4;B9TX31;Q71SY5-6 A0A0C4DGR2;M0QZQ2 PTOV1;MED25 Prostate tumor-overexpressed gene 1 protein;Mediator of RNA polymerase II transcription subunit 25 0 505080000.0 221100000.0 175960000.0 108020000.0 False True 335424864.5751585 144558563.21824515 86669799.65315218 1.0 0.43097151846909065 0.25838811849242654 28.321414396926833 -13.999999999999998 0.16714548318278796 3.8488180355999213 0.10142957842480385 0.9995194176431723 0.006946125047616871 12.06503568158363 0.12940365152604572 11.141894277613153 0.14444798603951786 1.0000000000000041e-14 13.999999999999998 -3.7473884571751173 LINANMMVLGHEPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LINANMMVLGHEPR 14 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 57230600.0 8472600.0 29477000.0 19281000.0 False True 12853553.630029356 24216599.045147825 15470101.898837507 1.0 1.8840392114264293 1.2035661377484894 23.615663941580088 -10.249140825670347 5.073415664956438 0.9999197233554642 1.5438026744839373 0.45990588694401213 0.2778019690464617 0.00026504617701347225 3.9227368937092745e-05 0.2690220524292143 0.08966019997010123 5.634549185675329e-11 10.249140825670347 0.5438829511284731 LINHSK(ub)CGNCQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LINHSKCGNCQTK 13 1 C9JKQ0;A0A0C4DFR3;Q9NQR1-2;Q9NQR1 C9JKQ0 SETD8 N-lysine methyltransferase SETD8 1 1907040.0 385220.0 404120.0 1117700.0 True False 505027.15047578665 343826.87124742253 1002051.1257354628 1.0 0.6808086870646516 1.9841529802732967 18.94600142428909 -6.841950935937444 1.273310001308807 0.8302195957057019 2.0287019846105814 0.9277576630183326 0.14908968831453615 0.16653078479573227 0.5236319542414485 0.09178193741408966 0.21157060439629866 1.438961134526191e-07 6.841950935937444 1.1984823889048795 LINTQAIFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LINTQAIFAK 10 0 P49366;P49366-3;A0A087WZK0;M0R0V2 P49366 DHPS Deoxyhypusine synthase 0 3217290.0 1037200.0 892790.0 1287300.0 False True 1420680.8692760782 853343.5857382755 983266.2527757102 1.0 0.6006581803083652 0.6921091668368443 20.438151084481785 -10.122911705755373 5.67566529686942 1.0000037193985225 0.6463836735725733 0.9522341825553529 0.03733470891161438 1.7571645387166667e-06 2.7153682578345585e-07 0.036149556675125295 0.012049725487496563 7.535087402654986e-11 10.122911705755373 -0.3536200458259492 LIPDGCGVK(ub)YIPNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIPDGCGVKYIPNR 14 1 P27635 P27635 RPL10 60S ribosomal protein L10 1 15461800.0 5798800.0 9663000.0 0.0 True False 7602282.955659074 8221318.0660789935 0.0 1.0 1.081427528287291 0.0 22.85800129238371 -6.970257399082959 1.1692184654907207 1.0513350125994616 4.455712371447188e-21 0.9775925514910891 0.07360646530391958 0.10008469774118603 0.27037497432283353 0.05267555929973011 0.09853194040929067 1.0708844218099948e-07 6.970257399082959 -1.0513350125994616 down LIPHLCILFGDSNSQVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIPHLCILFGDSNSQVR 17 0 E7ERI8;E7EW49;O75122-3 E7ERI8 CLASP2 CLIP-associating protein 2 0 6412900.0 1709200.0 2711900.0 1991800.0 False True 2240777.7519163466 2307295.0909034032 1785707.6426947261 1.0 1.0296849336932992 0.7969142147933066 21.09556813378671 -6.874878090984654 1.1079180758260816 1.0174036529111277 0.7819531021349857 0.9693161474186384 0.01812020613621487 0.1322661714478227 0.300498932955795 0.012651096555425853 0.0302341638316004 1.3338958120152088e-07 6.874878090984654 -0.23545055077614196 LIPHLCILFGDSNSQVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIPHLCILFGDSNSQVR 17 0 E7ERI8;E7EW49;O75122-3 E7ERI8 CLASP2 CLIP-associating protein 2 0 64760000.0 17710000.0 26302000.0 20748000.0 False True 26867364.774428148 21608202.601536054 16647148.705828544 1.0 0.8042546331935886 0.6196048196611 24.67935148897516 -6.971831535655866 0.20989382516955066 1.0968059729947734 0.3218994591688089 0.999993359560252 0.0004001973289267526 0.0757128583411231 0.0068619038670484625 0.005534074030585038 0.019138893271196805 1.067009937840705e-07 6.971831535655866 -0.7749065138259645 LIPHLCILFGDSNSQVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIPHLCILFGDSNSQVR 17 0 E7ERI8;E7EW49;O75122-3 E7ERI8 CLASP2 CLIP-associating protein 2 0 13496600.0 1709200.0 3595800.0 8191600.0 False True 2341137.4293932435 3436925.666279526 6256912.791297687 1.0 1.4680580572197677 2.672595257647605 21.1587781953096 -6.954837912868567 0.5029367978998797 0.9764788860990647 3.2163872719314317 0.9995282809385408 0.015302266994285591 0.08159930632712209 0.028358149189439897 0.017848032145563554 0.09937467060087889 1.1095888580950338e-07 6.954837912868567 2.2399083858323667 LIPHLCILFGDSNSQVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIPHLCILFGDSNSQVR 17 0 E7ERI8;E7EW49;O75122-3 E7ERI8 CLASP2 CLIP-associating protein 2 0 42655000.0 17710000.0 13485000.0 11460000.0 False True 22925944.11629073 12734547.895732325 9374397.589529876 1.0 0.5554644917189431 0.4088990857684509 24.45047781106761 -13.999999999999998 0.1550870562060236 3.168095073231071 0.2567120273693544 0.9995501579376433 0.005330540944243659 11.980536816235892 0.12426576797418425 7.818277635489211 0.13790030322288474 1.0000000000000041e-14 13.999999999999998 -2.911383045861717 LIPHQVVTHLLALHADIPETCVHYVGGPLDALIQGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIPHQVVTHLLALHADIPETCVHYVGGPLDALIQGLK 37 0 Q9H6R4-4;Q9H6R4;A0A0A0MRW6;Q9H6R4-3;Q9H6R4-2 Q9H6R4-4 NOL6 Nucleolar protein 6 0 557380000.0 240750000.0 160210000.0 156420000.0 False True 365235351.18258435 131619273.77355653 125503518.4386786 1.0 0.3603683853367165 0.3436236882117643 28.44425116984143 LIPHQVVTHLLALHADIPETCVHYVGGPLDALIQGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIPHQVVTHLLALHADIPETCVHYVGGPLDALIQGLK 37 0 Q9H6R4-4;Q9H6R4;A0A0A0MRW6;Q9H6R4-3;Q9H6R4-2 Q9H6R4-4 NOL6 Nucleolar protein 6 0 342216000.0 240750000.0 45619000.0 55847000.0 False True 311655620.8919812 43080262.54767611 45683419.03861034 1.0 0.1382303403493165 0.14658301014389233 28.21537749193388 -10.330242168639892 3.9665827103023803 1.00188988361317 0.14240667518613495 0.9999288590741315 0.0034099634005174094 9787723.61994074 15552599.93367593 214257.43956610188 0.00124792107665326 4.6747439837449454e-11 10.330242168639892 -0.8594832084270351 LIPLK(ub)TMTSDILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIPLKTMTSDILK 13 1 B1AK44;Q9UI95 B1AK44 MAD2L2 Mitotic spindle assembly checkpoint protein MAD2B 1 8183800.0 2014600.0 3186800.0 2982400.0 True False 1950647.625736285 4459305.85894246 2201219.969917829 1.0 2.286064279425796 1.1284559757875101 20.89552175551453 -6.6210400597484345 2.1134485275646275 1.8527575899596451 1.1329538387944964 0.0860569661573144 0.5529158163439739 0.5826874341304691 4.9473200777913915 0.21488640451876728 0.6128278727626318 2.393095004796915e-07 6.6210400597484345 -0.7198037511651487 LIPLK(ub)TMTSDILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIPLKTMTSDILK 13 1 B1AK44;Q9UI95 B1AK44 MAD2L2 Mitotic spindle assembly checkpoint protein MAD2B 1 5030900.0 2014600.0 3016300.0 0.0 True False 1675229.161912481 3000050.593211325 0.0 1.0 1.7908299720537317 0.0 20.675927030948806 -6.7967302136054455 1.5354834548216951 1.443365932109518 4.514963097770338e-18 0.7899272923778503 0.3358526471240548 0.23395545211588237 1.0997718838449038 0.173862521961964 0.39387165108715283 1.5968708251326676e-07 6.7967302136054455 -1.443365932109518 LIQEGK(ub)AYVDDTPAEQMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIQEGKAYVDDTPAEQMK 18 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 10244000.0 2707900.0 4309400.0 3226700.0 True False 3550083.1233409 3666454.31790963 2892832.036691977 1.0 1.0327798506473325 0.8148631838145809 21.759421374287335 -6.868582993382248 1.141482627638073 1.018391551706026 0.8024354765693419 0.9632527139847532 0.01839101608313205 0.13822518567322623 0.33748654839672765 0.01251365320465234 0.02955766530162387 1.3533714375901244e-07 6.868582993382248 -0.21595607513668413 LIQEGK(ub)AYVDDTPAEQMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIQEGKAYVDDTPAEQMK 18 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 17087400.0 3302400.0 13785000.0 0.0 True False 5009982.237779299 11324959.04730342 0.0 1.0 2.2604788819217987 0.0 22.256374057871774 -6.75835809258496 1.6382673697541386 1.7362264341122797 8.186582521048216e-08 0.6716420052308414 0.5299777348038884 0.28846625252410696 1.5288232052468105 0.2561566786222094 0.6118274625812675 1.7443832483805408e-07 6.75835809258496 -1.7362263522464545 LIQEGK(ub)AYVDDTPAEQMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIQEGKAYVDDTPAEQMK 18 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 11383200.0 2707900.0 2026200.0 6649100.0 True False 3709083.808245937 1936675.7842526175 5078719.522512995 1.0 0.5221439806636483 1.3692652377447283 21.822631435810226 -6.753646028156855 1.6362655935790344 0.7202562893463431 1.3714388004813003 0.6645622501990417 0.20084548655355222 0.2937183276042364 1.5482590823990319 0.09691906808248177 0.23440766176768638 1.7634127309036326e-07 6.753646028156855 0.6511825111349572 LIQEGK(ub)AYVDDTPAEQMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIQEGKAYVDDTPAEQMK 18 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 8562200.0 2019400.0 2829100.0 3713700.0 True False 1679220.574588539 2813859.0767676155 4490217.499791276 1.0 1.6756935445821928 2.673989092166476 20.679360317743278 -6.965507855491119 0.3492263150387184 0.9026639192815291 3.4806648214563443 0.9999232349276973 0.006024629300274326 0.07778904456312563 0.014254638084213364 0.013730349888273279 0.08585046605534513 1.0826601318622032e-07 6.965507855491119 2.578000902174815 LIQEGK(ub)AYVDDTPAEQMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIQEGKAYVDDTPAEQMK 18 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 54499200.0 3302400.0 8814800.0 42382000.0 True False 4275021.900036046 8324248.631168055 34668910.87604318 1.0 1.9471826872039806 8.10964521041421 22.027500379964223 -6.934146058322156 0.7119351780805688 0.9191461873701713 9.519601352153359 0.9972922276683989 0.1640221596485873 0.0905414713338444 0.06754736902622992 0.15330539287804607 0.5454449640719464 1.163734586015899e-07 6.934146058322156 8.600455164783188 LIQELAK(ub)CK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIQELAKCK 9 1 O43681 O43681 ASNA1 ATPase ASNA1 1 3415760.0 935260.0 780400.0 1700100.0 True False 1226134.9170707231 663967.3619753739 1524189.9605107482 1.0 0.5415124818087833 1.2430850302771643 20.225686303230265 -6.730366314195387 1.721877527874059 0.7241994012979961 1.242697678958331 0.5609899091786266 0.1927313780506703 0.33554238976425727 1.949142793632976 0.08869464532223428 0.2199999556746749 1.8605171849563703e-07 6.730366314195387 0.518498277660335 LIQFLISLVQSNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIQFLISLVQSNR 13 0 E9PMQ6;Q00613-2;Q00613;E9PI02 E9PMQ6 HSF1 Heat shock factor protein 1 0 402220000.0 108850000.0 164450000.0 128920000.0 False True 165133408.0009319 135102612.6462856 103438905.49235675 1.0 0.8181422177487137 0.626395995483682 27.299056779298816 -6.970455794213031 0.24705828135582303 1.0630963033624183 0.37584681806696957 0.9999857209427432 0.0005763875345773211 0.07615507054614822 0.008499332209331738 0.004363336683639467 0.018466719165429597 1.0703953303233896e-07 6.970455794213031 -0.6872494852954487 LIQFLISLVQSNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIQFLISLVQSNR 13 0 E9PMQ6;Q00613-2;Q00613;E9PI02 E9PMQ6 HSF1 Heat shock factor protein 1 0 337240000.0 108850000.0 112040000.0 116350000.0 False True 140908470.754277 105804875.50892463 95175493.85181515 1.0 0.7508766147454137 0.6754419613125089 27.070183101391265 -13.99999999999868 0.16737981848734315 2.2479529622696663 0.6070093162669161 0.9995189229060317 0.0030417411688604934 12.067132996890168 0.12949996400218627 4.888567514146887 0.06299981391532038 1.000000000003039e-14 13.99999999999868 -1.6409436460027502 LIQHANVQAHSSLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIQHANVQAHSSLIR 15 0 Q15833;Q15833-2;Q15833-3;M0R1A1;M0R376 Q15833 STXBP2 Syntaxin-binding protein 2 0 10431600.0 5174200.0 3962900.0 1294500.0 False True 6783426.307024074 3371650.767263216 1160557.557720816 1.0 0.49704244059848535 0.17108722129391848 22.69358273170623 -8.339217201869985 0.304317119908647 1.1538650966908555 2.45897003061316e-21 0.998826770828981 0.01167885332557575 0.11535972701236243 0.07627004591903898 0.09584470612424192 0.0956383955984198 4.5791281542942845e-09 8.339217201869985 -1.1538650966908555 LIQHANVQAHSSLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIQHANVQAHSSLIR 15 0 Q15833;Q15833-2;Q15833-3;M0R1A1;M0R376 Q15833 STXBP2 Syntaxin-binding protein 2 0 8236600.0 2734900.0 1219600.0 4282100.0 False True 2648082.096508573 1706592.6401299804 3160489.549753606 1.0 0.6444636449829401 1.1935013472281049 21.336516418957906 -6.731892235674341 1.716256391390088 0.7864925544876739 1.193293599689394 0.5680430714727751 0.1494381282294542 0.33270535172208404 1.9207333550265338 0.06897610635033154 0.17079894453379713 1.853991609387058e-07 6.731892235674341 0.4068010452017202 LIQHANVQAHSSLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIQHANVQAHSSLIR 15 0 Q15833;Q15833-2;Q15833-3;M0R1A1;M0R376 Q15833 STXBP2 Syntaxin-binding protein 2 0 22317000.0 3559600.0 9363600.0 9393800.0 False True 5400173.441617975 7692592.421859287 7537111.312551198 1.0 1.4245083986699634 1.395716525410888 22.364574313515796 -10.185812216747436 4.907412697394981 0.9999585682548403 1.4101124620413228 0.996317075185718 0.01175423304041163 5.328921133990561e-06 8.841351844223475e-07 0.01138213441100325 0.003793662400631418 6.519102105763723e-11 10.185812216747436 0.4101538937864825 LIQHANVQAHSSLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIQHANVQAHSSLIR 15 0 Q15833;Q15833-2;Q15833-3;M0R1A1;M0R376 Q15833 STXBP2 Syntaxin-binding protein 2 0 12354200.0 5174200.0 2751300.0 4428700.0 False True 7087241.567497371 2629738.468667571 3382732.271939556 1.0 0.3710524671160853 0.47729885311840137 22.75679279322912 -10.101697003200073 5.484912864666681 1.0000068104552648 0.42417566011832064 0.9751022710366338 0.043374905454106834 120791021.92090015 31.90816904044143 10389.567321255785 0.014848383841681294 7.912304579117137e-11 10.101697003200073 -0.5758311503369442 LIQHANVQAHSSLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIQHANVQAHSSLIR 15 0 Q15833;Q15833-2;Q15833-3;M0R1A1;M0R376 Q15833 STXBP2 Syntaxin-binding protein 2 0 6370700.0 2734900.0 2015700.0 1620100.0 False True 2274190.52661295 2004841.024014877 1958855.4195039566 1.0 0.8815624726925466 0.8613418254016582 21.116921694392182 -13.999999999999998 0.24869384346014006 1.8182866313475041 0.8531098035386843 0.9995402428350941 0.0013113282141425267 13.9465424280103 0.15780509322585975 5.6967092226227205 0.009399928764101725 1.0000000000000041e-14 13.999999999999998 -0.9651768278088199 LIQHANVQAHSSLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIQHANVQAHSSLIR 15 0 Q15833;Q15833-2;Q15833-3;M0R1A1;M0R376 Q15833 STXBP2 Syntaxin-binding protein 2 0 20484500.0 3559600.0 10425000.0 6499900.0 False True 4607972.370206008 9844839.585688492 5316984.894606042 1.0 2.1364797344148054 1.1538664877819864 22.135700635608245 -6.610878063791554 2.15047911561246 1.7588451431538754 1.1574057915658047 0.05308180501995985 0.4898663572615639 0.610265230682375 5.3493024604516926 0.1880270543985516 0.5437668255571236 2.4497509581874587e-07 6.610878063791554 -0.6014393515880707 LIQIAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIQIAAR 7 0 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;Q9BUJ2-3 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 0 6024900.0 2229800.0 1460600.0 2334500.0 False True 2923289.393413916 1242684.1733742068 2092948.3341052507 1.0 0.4250978969697414 0.715956599719686 21.479161226308285 -10.518970393662407 6.386764177553889 1.0003636745889823 0.5705272483447277 0.744049496769196 0.11874256816420177 0.0006153996817980933 4.6349699271175516e-05 0.1150660503905733 0.03832399908215436 3.027119783188063e-11 10.518970393662407 -0.42983642624425467 LIQIAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIQIAAR 7 0 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;Q9BUJ2-3 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 0 3330530.0 1146500.0 741630.0 1442400.0 False True 1110104.9850623722 1037766.7265493586 1064592.1689275347 1.0 0.934836560968196 0.9590013406414166 20.082264691184786 -9.968188602912022 5.684861825063264 1.000000072315985 0.946918950920076 0.865475101519838 0.009865229991168503 9.045748883232541e-09 1.6274497879488075e-09 0.009551980960381193 0.0031839892885047005 1.0759978339953494e-10 9.968188602912022 -0.053081121395908926 LIQIAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIQIAAR 7 0 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;Q9BUJ2-3 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 0 7852700.0 2229800.0 1905000.0 3717900.0 False True 3054217.3180792476 1820830.8010074233 2839808.5925540365 1.0 0.596169365627367 0.9297991258657228 21.542371287831177 -9.992079702190512 6.8592289731119 1.0000000289215194 0.7629842457465443 0.4022428743273375 0.13620377926517932 6.018115911343612e-08 8.881399523123409e-09 0.13187875791728135 0.04395958073204556 1.018404472218851e-10 9.992079702190512 -0.23701578317497507 LIQIAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIQIAAR 7 0 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;Q9BUJ2-3 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 0 2624240.0 1146500.0 943860.0 533880.0 False True 953365.5485618302 938775.238838458 645511.8396177841 1.0 0.9846959964670614 0.6770874410047131 19.862669966619062 -6.91724111932325 0.844932242632897 1.0074852443447524 0.630498989610617 0.9933796781474317 0.01210281317892625 0.09982248485942238 0.11422547433278563 0.010278243359507479 0.03002120856433815 1.2099261987248795e-07 6.91724111932325 -0.3769862547341354 LIQQQLEK(ub)ELNTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIQQQLEKELNTLR 14 1 Q9Y5M8;H7C4H2 Q9Y5M8 SRPRB Signal recognition particle receptor subunit beta 1 10982600.0 1999700.0 1780000.0 7202900.0 True False 1936220.618080438 2490763.2825773736 5316244.407631824 1.0 1.2864046892790073 2.7456811264112706 20.884811915778002 -6.939385395028284 0.6652553205882915 0.9834338877633937 3.1321889810471313 0.9980823047639085 0.03347470292227173 0.0880481126092564 0.055894629720448986 0.03243535859719074 0.12594091347060446 1.1497796160876864e-07 6.939385395028284 2.1487550932837376 up LIQQQLEK(ub)ELNTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIQQQLEKELNTLR 14 1 Q9Y5M8;H7C4H2 Q9Y5M8 SRPRB Signal recognition particle receptor subunit beta 1 10112800.0 1999700.0 3232900.0 4880200.0 True False 1662839.1517305619 3215483.7260195957 5900627.256504656 1.0 1.9337310663350418 3.5485255746857494 20.665217191212278 -6.962785337474026 0.39422495479194886 0.9053763192841016 4.635295689335905 0.9998599538370753 0.012458267283058762 0.07872082364265807 0.0175622430401874 0.02080759334090607 0.13559640358934175 1.0894684613605373e-07 6.962785337474026 3.729919370051803 LIQQQLVLLLHAHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIQQQLVLLLHAHK 14 0 A0A669KB12;Q09472;Q92793;Q92793-2 A0A669KB12;Q92793 EP300;CREBBP Histone acetyltransferase p300;CREB-binding protein 0 9393500.0 3494800.0 3845400.0 2053300.0 False True 3383859.486956803 5380888.273496083 1515479.132320373 1.0 1.5901630355033631 0.4478552192139883 21.690238231848404 -6.766298377193777 1.5887728820565723 1.3400998458934676 0.44233174994998725 0.7161543282887578 0.2485013908127486 0.2724538818645034 1.356683297040428 0.1233339000686841 0.29457628326153257 1.7127801566226288e-07 6.766298377193777 -0.8977680959434804 down LIQQQLVLLLHAHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIQQQLVLLLHAHK 14 0 A0A669KB12;Q09472;Q92793;Q92793-2 A0A669KB12;Q92793 EP300;CREBBP Histone acetyltransferase p300;CREB-binding protein 0 32076100.0 6094100.0 11077000.0 14905000.0 False True 9245195.23838749 9100222.805003967 11959020.216906436 1.0 0.9843191593421874 1.2935389581877863 23.14027235585243 -6.8949544210190385 0.9925787572213813 0.9853043073464014 1.3228704554950153 0.9838856340049313 0.018053204669932935 0.11521654871333244 0.1990868057214397 0.013759822236756243 0.03497658034004722 1.2736367415191648e-07 6.8949544210190385 0.33756614814861385 LIQQQLVLLLHAHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIQQQLVLLLHAHK 14 0 A0A669KB12;Q09472;Q92793;Q92793-2 A0A669KB12;Q92793 EP300;CREBBP Histone acetyltransferase p300;CREB-binding protein 0 8897900.0 1280100.0 3009700.0 4608100.0 False True 1753387.5634017584 2876721.502253036 3519761.6867985316 1.0 1.6406649404264566 2.007406554184643 20.741713489550754 -9.430457804920593 0.14020752747116402 1.9880769034829175e-21 2.662834278333988 0.9998327028481594 0.0053846795688092695 0.8855781623043284 0.05460791680741791 0.6773205596678562 0.3269360103656771 3.711437872405706e-10 9.430457804920593 2.662834278333988 LIQQQLVLLLHAHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIQQQLVLLLHAHK 14 0 A0A669KB12;Q09472;Q92793;Q92793-2 A0A669KB12;Q92793 EP300;CREBBP Histone acetyltransferase p300;CREB-binding protein 0 8238800.0 3494800.0 1827600.0 2916400.0 False True 2906081.045890869 1817754.3560498036 3526205.7560899495 1.0 0.6255002277448751 1.2133886496647857 21.47064350728268 -6.734611677464117 1.7064661152545926 0.7757939361329413 1.2133412614126193 0.5805002563792037 0.15738175574366706 0.32765309694653505 1.8712340956358962 0.07302645967434786 0.1802683208630481 1.8424186558711025e-07 6.734611677464117 0.437547325279678 LIQQQLVLLLHAHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIQQQLVLLLHAHK 14 0 A0A669KB12;Q09472;Q92793;Q92793-2 A0A669KB12;Q92793 EP300;CREBBP Histone acetyltransferase p300;CREB-binding protein 0 26643300.0 6094100.0 11943000.0 8606200.0 False True 7888932.582670085 11278361.551259259 7039959.907069109 1.0 1.4296435459513064 0.892384341391642 22.91139867794488 -6.693721060432169 1.8529846442668947 1.2684112130017948 0.8941427569909963 0.3879795137413481 0.18157370516088905 0.4087259285111572 2.7236560158280447 0.0783037660313753 0.2029729084845753 2.024318945029592e-07 6.693721060432169 -0.3742684560107985 LIQVPK(ub)GPVEGYEENEEFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIQVPKGPVEGYEENEEFLR 20 1 F5GX77;Q9UI30;F5GYQ2 F5GX77 TRMT112 Multifunctional methyltransferase subunit TRM112-like protein 1 29814700.0 10935000.0 15650000.0 3229700.0 True False 14335890.89469062 13315081.003222207 2895521.625470009 1.0 0.9287934109594489 0.2019770969757019 23.773128226928414 -6.925863608931419 0.7799984927543596 1.0129102286695535 0.06735483546973592 0.9956609099074565 0.02375215844931717 0.09484330878364587 0.08862464261613003 0.021128727301934404 0.06732196202653366 1.1861411997445984e-07 6.925863608931419 -0.9455553931998175 down LIQVPK(ub)GPVEGYEENEEFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIQVPKGPVEGYEENEEFLR 20 1 F5GX77;Q9UI30;F5GYQ2 F5GX77 TRMT112 Multifunctional methyltransferase subunit TRM112-like protein 1 73883000.0 35044000.0 23973000.0 14866000.0 True False 33931547.40211574 33545543.91754343 10972148.629559569 1.0 0.9886240530089045 0.3233612808614623 25.01612388790777 -6.910611920970726 0.8915611933558363 1.0202017033395585 0.23625359307480873 0.9911502559351362 0.029757506901387763 0.10401497464342563 0.13658447360169387 0.024436754086550442 0.0677456054294728 1.2285365426262083e-07 6.910611920970726 -0.7839481102647498 down LIQVPK(ub)GPVEGYEENEEFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIQVPKGPVEGYEENEEFLR 20 1 F5GX77;Q9UI30;F5GYQ2 F5GX77 TRMT112 Multifunctional methyltransferase subunit TRM112-like protein 1 120333000.0 32604000.0 36403000.0 51326000.0 True False 49462651.671680145 29906600.23206283 41181393.603015 1.0 0.6046299424174597 0.8325755334826381 25.559836248279016 -10.199566078819217 5.4690542723338655 1.000011795145734 0.7186027379500185 0.6701808149390653 0.09305839787124123 1.3384179740745314e-05 1.958997819598107e-06 0.09010718124834091 0.030034468764989542 6.315880745219722e-11 10.199566078819217 -0.2814090571957154 LIQVPK(ub)GPVEGYEENEEFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIQVPKGPVEGYEENEEFLR 20 1 F5GX77;Q9UI30;F5GYQ2 F5GX77 TRMT112 Multifunctional methyltransferase subunit TRM112-like protein 1 36974800.0 10935000.0 18203000.0 7836800.0 True False 14977965.007263675 17398731.270728648 5985909.243962318 1.0 1.1616218399689813 0.39964769853978205 23.836338288451305 -6.851264372615059 1.228884546564826 1.0863547270279594 0.3684214559154842 0.9421325397293534 0.07885743935674651 0.15607605929525345 0.4529152228479818 0.050194219324795876 0.11625647494563907 1.4084311683987336e-07 6.851264372615059 -0.7179332711124753 down LIQVPK(ub)GPVEGYEENEEFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIQVPKGPVEGYEENEEFLR 20 1 F5GX77;Q9UI30;F5GYQ2 F5GX77 TRMT112 Multifunctional methyltransferase subunit TRM112-like protein 1 70790100.0 35044000.0 31762000.0 3984100.0 True False 29140638.71242975 31590891.801736616 4817156.88960293 1.0 1.0840837125598666 0.16530718276769285 24.796529163342047 -6.884528868210937 1.0541834500335987 1.0560335519864137 0.09425449038310142 0.9771600638144698 0.06267613297744282 0.12369553779876305 0.24866681675022076 0.045595086122786566 0.11164873342971314 1.3045812482693946e-07 6.884528868210937 -0.9617790616033123 down LIQVPK(ub)GPVEGYEENEEFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIQVPKGPVEGYEENEEFLR 20 1 F5GX77;Q9UI30;F5GYQ2 F5GX77 TRMT112 Multifunctional methyltransferase subunit TRM112-like protein 1 137694000.0 32604000.0 46500000.0 58590000.0 True False 42206520.720922805 43912234.123214856 47927221.18416708 1.0 1.0404135041969116 1.1355406786802111 25.330962570371465 -6.956739929848275 0.4791828347487593 0.9976990256542534 1.182215726935523 0.9996294859956696 0.0010936435101049171 0.08088703273085807 0.025596316409895018 0.0013390496173265826 0.007847409729580406 1.1047399773386612e-07 6.956739929848275 0.1845167012812695 LISEMHSFIQIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LISEMHSFIQIK 12 0 Q16666;Q16666-2;Q16666-3;Q16666-6 Q16666 IFI16 Gamma-interferon-inducible protein 16 0 30516100.0 6095100.0 12076000.0 12345000.0 False True 9246712.311497286 9920943.449781364 9905005.338994281 1.0 1.072915768931812 1.0711921172975696 23.140509072789413 -10.26692191751516 6.971621499099377 0.9999994416393144 1.0720539431146907 0.9995709700416882 0.000703677833034738 6.106369160860109e-09 6.422308147984513e-10 0.000681338411478089 0.00022711104403657785 5.408515547523837e-11 10.26692191751516 0.07205450147537629 LISGEEHFSSKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LISGEEHFSSKK 12 1 Q9BTE7;H0YCN4;E9PQV9 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 1 4758900.0 1710100.0 1698500.0 1350300.0 True False 2241957.660631955 1445090.4207011457 1210583.908992213 1.0 0.6445663297199862 0.5399673375861067 21.096327602430456 -13.999999997796555 0.171469666009705 2.799462723073279 0.4491279711276309 0.9995109506971404 0.004354193430761836 12.106151736470359 0.13115659648470981 7.247070645226354 0.08415048765842999 1.0000000050736185e-14 13.999999997796555 -2.350334751945648 LISGEEHFSSKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LISGEEHFSSKK 12 1 Q9BTE7;H0YCN4;E9PQV9 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 1 4619800.0 1219600.0 1453000.0 1947200.0 True False 1180884.4655752883 2033190.4772948986 1437169.905252146 1.0 1.7217522429718768 1.217028377583072 20.171436391726377 -10.616320135208273 5.777564624396436 0.9971503015513438 1.4693903102774744 0.5355719009299977 0.2060526552012927 0.007598480910599544 0.000504603768993326 0.20043193250172062 0.06650320850303548 2.4192450704746607e-11 10.616320135208273 0.4722400087261306 LISGEEHFSSKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 LISGEEHFSSKK 12 1 Q9BTE7;H0YCN4;E9PQV9 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 1 15589700.0 2007800.0 2638900.0 10943000.0 True False 3045979.389841716 2167967.677180195 8780111.253512716 1.0 0.7117473231796403 2.882524840054474 21.53847474940488 -6.873449266023732 1.1157430712210745 0.8330417410091585 3.018244808123171 0.9680034027412768 0.1721846826232808 0.13358786629713165 0.30873503354580084 0.119502284062242 0.284736065968545 1.3382915443007177e-07 6.873449266023732 2.1852030671140126 up LISGEEHFSSKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LISGEEHFSSKK 12 1 Q9BTE7;H0YCN4;E9PQV9 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 1 4568400.0 1710100.0 1481200.0 1377100.0 True False 2342370.183714825 1415755.68632661 1051857.3422647647 1.0 0.6044115896665515 0.44905683549839126 21.159537663953348 -13.999999999999982 0.12916462345224827 2.879774134028768 0.22916726594449116 0.9996494142844767 0.004342817358291773 11.938057266700032 0.11167960374223837 5.701558414128911 0.1954954064323785 1.0000000000000409e-14 13.999999999999982 -2.6506068680842767 LISGEEHFSSKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LISGEEHFSSKK 12 1 Q9BTE7;H0YCN4;E9PQV9 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 1 18620700.0 2007800.0 3163900.0 13449000.0 True False 2599136.6796549116 2987826.1837083744 11001419.99839331 1.0 1.1495456191650026 4.232720843235521 21.30960107149733 -6.917000332163023 0.8466821661773142 0.924343171781447 4.69714462050332 0.9933061764318709 0.12189917441601801 0.09996893528210836 0.1149994391185695 0.10339329658486944 0.3013593070366166 1.2105972076446769e-07 6.917000332163023 3.7728014487218724 up LISGLHASINVHLSAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LISGLHASINVHLSAR 16 0 Q96HE7 Q96HE7 ERO1L ERO1-like protein alpha 0 26305900.0 7046300.0 11926000.0 7333600.0 False True 10689752.253532063 9797712.121736692 5884110.745568933 1.0 0.9165518423029283 0.5504440707337 23.349725081653244 -6.942757754432656 0.6333871045171917 1.0039954580319004 0.4431543242838641 0.9985032742953603 0.007553695463058644 0.08653072340394886 0.04904717089479038 0.007516825395972844 0.0311475625567541 1.1408859860835695e-07 6.942757754432656 -0.5608411337480363 LISGLHASINVHLSAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LISGLHASINVHLSAR 16 0 Q96HE7 Q96HE7 ERO1L ERO1-like protein alpha 0 21440400.0 7046300.0 9667000.0 4727100.0 False True 9121574.25333818 9129022.95202405 3866816.304141944 1.0 1.0008166023187437 0.42391984067079463 23.120851403745693 -6.906577396594456 0.9187287482534693 1.019852254972081 0.3545764397410177 0.9895645681003593 0.02776130600344825 0.10672499427342452 0.15136679738547387 0.02235072911087007 0.06032853847397192 1.2400026217761306e-07 6.906577396594456 -0.6652758152310633 down LISGWVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LISGWVSR 8 0 O14980 O14980 XPO1 Exportin-1 0 27497200.0 8218400.0 6517800.0 12761000.0 False True 10774401.987098824 5545369.646185408 11440614.132155538 1.0 0.5146800400454138 1.061832865142254 23.36110446167541 -6.672643648223753 1.9278291393929134 0.6909321027935753 1.059657041802699 0.29087942040008974 0.20602806219741218 0.45507897030994215 3.2631155978421424 0.08595641546154975 0.22887966222956296 2.1249873633436816e-07 6.672643648223753 0.3687249390091236 LISLHPFNPWNWGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LISLHPFNPWNWGK 14 0 Q96K31;Q96EF9;A0A0X1KG80 Q96K31 C8orf76;ZHX1-C8orf76 Uncharacterized protein C8orf76;Zinc fingers and homeoboxes protein 1, isoform 2 0 3418500.0 1095800.0 1179800.0 1142900.0 False True 911206.2521710015 1173444.1832280355 1381875.1058274626 1.0 1.2877920673088414 1.5165338281372251 19.797418120456886 -6.97371731093648 0.143923286838079 0.7103106416208516 2.100000787596118 0.9999987857752792 0.0002328000579518182 0.07511392699893091 0.0043741053954653 0.012414399497607267 0.02927514266191045 1.0623868563887404e-07 6.97371731093648 1.3896901459752666 LISLTDENALSGNEELTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LISLTDENALSGNEELTVK 19 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 22338500.0 10202000.0 5249300.0 6887200.0 False True 9878143.09429246 7345372.864737869 5083235.708428808 1.0 0.7435985482921368 0.5145942572309845 23.235808437000934 -6.972462313986254 0.1903951514174729 1.1544073228908296 0.0975268451605115 0.9999957602536272 0.0004082124588119146 0.07551148065904181 0.0060768112971295715 0.00805765102382431 0.024936706922903774 1.0654613153319429e-07 6.972462313986254 -1.056880477730318 LISQIVSSITASLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LISQIVSSITASLR 14 0 F8VVB9;P68363;P68363-2;C9JDS9;P68366-2;P68366;Q9BQE3;F5H5D3 F8VVB9;P68363;P68366-2;Q9BQE3 TUBA1B;TUBA4A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1C chain 0 711436000.0 443280000.0 213350000.0 54806000.0 False True 581144372.7296264 181519011.6317862 49135200.85627432 1.0 0.31234753384807656 0.0845490435113172 29.114321373583916 -9.930863409545465 0.2871681591499265 1.4926055555019273 1.739987343202365e-24 0.9988445290880417 0.013227434890064244 1.372730639093347 0.13027469871960942 0.6460887416202737 0.08462042855487874 1.172564092035333e-10 9.930863409545465 -1.4926055555019273 LISQIVSSITASLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LISQIVSSITASLR 14 0 F8VVB9;P68363;P68363-2;C9JDS9;P68366-2;P68366;Q9BQE3;F5H5D3 F8VVB9;P68363;P68366-2;Q9BQE3 TUBA1B;TUBA4A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1C chain 0 7549363800.0 3529639500.0 1205186500.0 2814537800.0 False True 3417593026.0994835 1686423754.4145715 2077325915.8558893 1.0 0.493453650430489 0.607833027511398 31.670333462180675 -9.83003338571945 6.458563713326613 1.000000012482089 0.5506433389709245 0.9536587896777451 0.04669518515788072 8.36147152114847e-09 1.5647076061330942e-09 0.04521241996344647 0.015070806205337654 1.4789946883591122e-10 9.83003338571945 -0.4493566735111644 LISQIVSSITASLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LISQIVSSITASLR 14 0 F8VVB9;P68363;P68363-2;C9JDS9;P68366-2;P68366;Q9BQE3;F5H5D3 F8VVB9;P68363;P68366-2;Q9BQE3 TUBA1B;TUBA4A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1C chain 0 27213637370.0 9611894570.0 8157478000.0 9444264800.0 False True 14581946786.3091 6701712316.2334795 7577601722.7116785 1.0 0.4595896840417547 0.5196563829067216 33.76346429072372 -10.108905015330556 5.106982908634865 1.000014357678009 0.4896230334753797 0.9897184556498716 0.02452212712896779 4.0088566323014345e-06 6.994767016162899e-07 0.02374411479101583 0.00791448249816501 7.782067342445151e-11 10.108905015330556 -0.5103913242026292 LISQIVSSITASLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LISQIVSSITASLR 14 0 F8VVB9;P68363;P68363-2;C9JDS9;P68366-2;P68366;Q9BQE3;F5H5D3 F8VVB9;P68363;P68366-2;Q9BQE3 TUBA1B;TUBA4A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1C chain 0 829570000.0 443280000.0 110980000.0 275310000.0 False True 607172595.1915728 106076536.63821726 210287448.18743184 1.0 0.17470573849721988 0.3463388332292612 29.177531435106808 -10.291398006349388 8.256684801757741 1.0000010428499067 0.260522286483022 0.9611660492944334 0.07006891751137811 1.34515545938606e-06 1.1546181407349547e-07 0.06784403366584123 0.022614645884029075 5.112131228618473e-11 10.291398006349388 -0.7394787563668846 LISQIVSSITASLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LISQIVSSITASLR 14 0 F8VVB9;P68363;P68363-2;C9JDS9;P68366-2;P68366;Q9BQE3;F5H5D3 F8VVB9;P68363;P68366-2;Q9BQE3 TUBA1B;TUBA4A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1C chain 0 10282656500.0 3529639500.0 2809886000.0 3943131000.0 False True 2935051633.7924147 2794748586.3992987 4767621461.122181 1.0 0.9521974176611575 1.6243739654289766 31.45073873761495 -6.889819780516388 1.0234198034669781 0.9637270368100547 1.6819897960049397 0.9807836771127696 0.04244944828282406 0.11929068084142996 0.22268884977611203 0.0316107920142168 0.07875741481522579 1.2887842484408474e-07 6.889819780516388 0.718262759194885 LISQIVSSITASLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LISQIVSSITASLR 14 0 F8VVB9;P68363;P68363-2;C9JDS9;P68366-2;P68366;Q9BQE3;F5H5D3 F8VVB9;P68363;P68366-2;Q9BQE3 TUBA1B;TUBA4A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1C chain 0 20103797260.0 9611894570.0 5661742390.0 4830160300.0 False True 12442786999.63289 5346661448.924943 3951120687.0299134 1.0 0.4296996684973141 0.3175430622694487 33.534590612816174 -13.999999999999998 0.22864112067191478 4.577644561356773 0.26230168696174755 0.9995079684191087 0.006628063630121939 13.24930543086023 0.1514114305058133 21.502645356847466 0.05871544699338976 1.0000000000000041e-14 13.999999999999998 -4.315342874395025 LISQQK(ub)AFFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LISQQKAFFAK 11 1 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 1 34134800.0 3505000.0 5824800.0 24805000.0 True False 5317341.2498232955 4785318.930629879 19902280.877582297 1.0 0.8999458010690782 3.742900811236007 22.34227362623387 -6.898740356609794 0.9691746060102395 0.8776805815055784 4.033822069700532 0.9859298009316093 0.15624729205129956 0.11233918610793893 0.1826854026826574 0.12119185283101536 0.313381774870087 1.2625821449935938e-07 6.898740356609794 3.1561414881949537 up LISQQK(ub)AFFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LISQQKAFFAK 11 1 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 1 29932000.0 3505000.0 6134000.0 20293000.0 True False 4537291.593879104 5792637.507780645 16599882.223763503 1.0 1.2766729640199954 3.6585442835891513 22.113399948326318 -6.928757180919007 0.756925177484882 0.9620598138434225 4.132404324452325 0.9962882980582438 0.0727060622321475 0.0932882358715201 0.08087964596890514 0.06575560640481601 0.2170096744417026 1.1782645707738684e-07 6.928757180919007 3.1703445106089023 up LISSDGHEFIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LISSDGHEFIVK 12 0 E5RHG8;Q15369;R4GMY8;Q15369-2 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 0 9143900.0 1911900.0 3478800.0 3753200.0 False True 2506519.414865936 2959776.600256194 3364854.867236591 1.0 1.1808313084279463 1.342441174514726 21.257253978238897 -6.972455358090191 0.19062407370812112 0.8913589532159912 1.6363313305121976 0.9999957360743009 0.0002887728215924615 0.07551373014141105 0.006085763711603251 0.005675266294542093 0.017586897056556867 1.0654783804751318e-07 6.972455358090191 0.7449723772962064 LISSDGHEFIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LISSDGHEFIVK 12 0 E5RHG8;Q15369;R4GMY8;Q15369-2 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 0 5914400.0 1911900.0 4002500.0 0.0 False True 2618781.097154773 3825656.315502474 0.0 1.0 1.4608537993721336 0.0 21.320464039761788 -6.845044219522597 1.4175405639141094 1.2462449148573713 1.4477907832144372e-22 0.8878895971134797 0.2041718301699617 0.17937987952869017 0.7240291453555849 0.11566046960116083 0.24586242004377945 1.4287484770585282e-07 6.845044219522597 -1.2462449148573713 down LISSDGHEFIVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LISSDGHEFIVKR 13 1 E5RHG8;Q15369;R4GMY8;Q15369-2 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 1 11974500.0 1558100.0 4981500.0 5434900.0 True False 1508638.9683608194 6970638.928179324 4011336.6464949083 1.0 4.620481821275721 2.658910932715296 20.524816165862276 -10.145006716160756 7.038968519912661 0.9999974690523248 3.639696376995509 0.707136818443443 0.800807961878475 3.180698180203472e-05 3.863958003573983e-06 0.7753797131021525 0.25845965832213647 7.161323354761099e-11 10.145006716160756 2.639698907943184 LISSDGHEFIVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LISSDGHEFIVKR 13 1 E5RHG8;Q15369;R4GMY8;Q15369-2 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 1 3378050.0 1280700.0 843850.0 1253500.0 True False 1754209.3996161511 806565.9167612139 957449.1166428591 1.0 0.4597888467236029 0.5458009271027531 20.742389541597284 -10.76672323614187 7.064349093214448 1.0111837407435476 0.502794886913178 0.9780482431099269 0.03511428477402845 0.006121558221941671 0.00020214390342262168 0.03365011184410166 0.011333086678649735 1.7111054078474154e-11 10.76672323614187 -0.5083888538303696 LISSDGHEFIVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LISSDGHEFIVKR 13 1 E5RHG8;Q15369;R4GMY8;Q15369-2 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 1 12099970.0 1558100.0 5930000.0 4611870.0 True False 1295629.1855335243 5898053.912987163 5576190.694122399 1.0 4.5522700313040705 4.303847703018663 20.305221441296553 -10.181630605663894 4.411295899191685 0.9991595539727934 4.428058867258423 0.9960768147793667 0.10141799116978366 3814823.382059461 4402755.0176491365 25621.094920170275 0.03471807554369398 6.582174540102501e-11 10.181630605663894 3.42889931328563 LISSDGHEFIVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LISSDGHEFIVKR 13 1 E5RHG8;Q15369;R4GMY8;Q15369-2 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 1 9518600.0 5201600.0 2183200.0 2133800.0 True False 6733573.738864929 2061703.0008129631 1745470.2946368975 1.0 0.3061825830930162 0.2592190064782939 22.682940965231328 -13.818490694154965 0.38400871852880925 9.999999997673962 0.25533502028041216 0.9998101170447193 0.004666956611055947 21.236583280022995 0.20216857403940455 157.3694429943763 0.012583141417609668 1.51883048642347e-14 13.818490694154965 -9.74466497739355 LISTLIYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LISTLIYK 8 0 O14980 O14980 XPO1 Exportin-1 0 13055900.0 3603900.0 3361000.0 6091000.0 False True 4724747.800217243 2859551.9010753855 5460761.748997676 1.0 0.6052284739820195 1.1557784626613492 22.171805891867084 -6.714291112803559 1.7804361124900723 0.758366653269196 1.1546255288309526 0.48523065180909863 0.16624786892472415 0.36650727312964415 2.2674041752885232 0.07424311182048585 0.18760030912869347 1.9306737294041064e-07 6.714291112803559 0.39625887556175665 LISTLIYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LISTLIYK 8 0 O14980 O14980 XPO1 Exportin-1 0 12997900.0 3603900.0 2451600.0 6942400.0 False True 4936359.2217354905 2343280.205642937 5302748.103216105 1.0 0.4746980720781303 1.0742224917237289 22.235015953389976 -6.675274709234001 1.918964583693758 0.6662237576143248 1.071846086614928 0.3024525957336732 0.22287131695255813 0.4491414798002962 3.1935216467263317 0.09334167348976251 0.24765669212624936 2.1121525932711702e-07 6.675274709234001 0.40562232900060313 LISTLIYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LISTLIYK 8 0 O14980 O14980 XPO1 Exportin-1 0 5151400.0 1617400.0 1919700.0 1614300.0 False True 1344939.7629689502 1909358.195069386 1951842.6663201246 1.0 1.419660751835074 1.4512491340217633 20.35911012826811 -11.834450227250354 0.41245188308915354 9.209275352899474e-11 1.452820686258761 0.9997444655741381 0.003287882784632842 5.0696659575334015 0.2082030256332411 4.4324182908665986 0.0078106302605222494 1.4640293144672966e-12 11.834450227250354 1.4528206861666682 LISVETDIVVDHYKEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LISVETDIVVDHYKEEK 17 1 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 27955900.0 5808000.0 14448000.0 7699900.0 False True 8811160.62167582 11869641.517260758 6178011.3900139425 1.0 1.347114418509288 0.7011575041335394 23.070900635331636 -6.760745951464187 1.609721376194918 1.2014347227604578 0.698714168299472 0.6940028130212972 0.14601265053810009 0.28165585719080016 1.4385960269618268 0.07156363263718248 0.17184819081001626 1.7348185149564414e-07 6.760745951464187 -0.5027205544609858 LISVETDIVVDHYKEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LISVETDIVVDHYKEEK 17 1 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 15342900.0 5808000.0 5545200.0 3989700.0 False True 7518570.49279597 5236604.7453774465 3263615.5377790034 1.0 0.6964894125013494 0.43407394276692424 22.842026957424086 -7.181978019972074 0.19626838808548447 1.1779971180156303 6.67494697858991e-12 0.9999900616242481 0.0007289697246289396 0.08814566786354368 0.008817856371555135 0.013478408115428605 0.03593794247137481 6.576911228426606e-08 7.181978019972074 -1.1779971180089555 down LISVLNK(ub)STGEVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LISVLNKSTGEVTK 14 1 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7 Q9Y450 HBS1L HBS1-like protein 1 7649200.0 1387400.0 2444500.0 3817300.0 True False 1343357.7464243642 3420601.5978990975 2817434.613454711 1.0 2.546307271464928 2.0973077506374755 20.35741212596072 -10.55675382380134 5.644243660795875 0.9958372647063073 2.3218075110512024 0.9203527302475631 0.1833032867969031 0.009603848267699763 0.0007541953523818062 0.17751890483951352 0.05916088142245698 2.7748925836140353e-11 10.55675382380134 1.325970246344895 LISVLNK(ub)STGEVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LISVLNKSTGEVTK 14 1 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7 Q9Y450 HBS1L HBS1-like protein 1 6049800.0 1387400.0 3168200.0 1494200.0 True False 1153684.5722413273 3151132.277761538 1806630.3115997852 1.0 2.7313638004534098 1.5659655637848602 20.137817401394997 -10.49809447010555 5.107289460102868 0.9968608183671063 2.1486646821191586 0.5643306096714442 0.4757718378296178 0.017029254361837616 0.0016735039310548005 0.46128850558850754 0.15355470037570532 3.176183094821589e-11 10.49809447010555 1.1518038637520522 LISWYDNEFGYSNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LISWYDNEFGYSNR 14 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 209812000.0 76395000.0 87209000.0 46208000.0 False True 100154584.81023246 74197757.13801949 41426839.41843458 1.0 0.7408323570868515 0.41362898660034325 26.577653224499013 -6.967963093456691 0.3029167819340651 1.0548164368609194 0.08934955830377854 0.9999618490906304 0.0014818979430123156 0.07696935410428983 0.01138347581172436 0.00535141108053275 0.029256002727827198 1.0765566960221012e-07 6.967963093456691 -0.9654668785571409 down LISWYDNEFGYSNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LISWYDNEFGYSNR 14 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 288692000.0 125490000.0 48582000.0 114620000.0 False True 121506388.63975313 67981045.95178309 84597583.47370635 1.0 0.5594853629740897 0.6962397979296756 26.856456929856545 -10.80362106317121 10.574284513330399 1.0031198706706463 0.6278625804518844 0.9080316471738501 0.055829764283969505 0.004117022909742545 7.645861963871723e-05 0.05419748998728338 0.018018978941208304 1.571733597678167e-11 10.80362106317121 -0.375257290218762 LISWYDNEFGYSNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LISWYDNEFGYSNR 14 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 558647000.0 63729000.0 419460000.0 75458000.0 False True 96681552.21397683 344604085.7440613 60543693.22558367 1.0 3.5643209883657967 0.6262176375859958 26.52673729984534 -6.676059847647707 1.9157018653813078 2.6282170863896166 0.6376985264249501 0.30613724761573535 1.0877775904300844 0.4474168586071323 3.1710228227383728 0.45618295808053155 1.2093411855054987 2.1083375919245782e-07 6.676059847647707 -1.9905185599646664 LISWYDNEFGYSNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LISWYDNEFGYSNR 14 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 279921000.0 76395000.0 96306000.0 107220000.0 False True 104640295.99724835 92050882.47864617 81896844.26521535 1.0 0.8796886667930179 0.7826511143218567 26.640863286021904 -6.97356622161719 0.150282869148479 1.1123570774412388 0.5474298958942648 0.9999985284475643 0.00010768985348048696 0.07516155133629435 0.00459479036728016 0.004938389809659517 0.012091359434559775 1.0627565208403962e-07 6.97356622161719 -0.564927181546974 LISWYDNEFGYSNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LISWYDNEFGYSNR 14 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 254121000.0 125490000.0 80885000.0 47746000.0 False True 104350495.14960662 80449256.45058453 57729467.847439006 1.0 0.7709523211676663 0.5532265828223685 26.63686220529082 -6.97174034364274 0.2125487271526273 1.1103500458116227 0.2077332812905726 0.9999929610278376 0.0004839292766097133 0.07574193673348811 0.006972496439971499 0.0063898647917951835 0.022430513284342507 1.0672340093053889e-07 6.97174034364274 -0.9026167645210501 LISWYDNEFGYSNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LISWYDNEFGYSNR 14 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 334299000.0 63729000.0 154050000.0 116520000.0 False True 82498446.78639697 145476982.07916653 95314555.59616241 1.0 1.7633905575923399 1.1553496981943019 26.29786362193779 -10.076584489774335 4.408242224038367 0.9999663594586822 1.4593701270258397 0.43214876831435334 0.24823164153253927 86195040.7843564 2.3963380885181986 34157.126726079616 0.08497629344855372 8.383309697459257e-11 10.076584489774335 0.4594037675671575 LITAHVEPLLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LITAHVEPLLAR 12 0 Q15306;Q15306-2 Q15306 IRF4 Interferon regulatory factor 4 0 17256600.0 5994900.0 5941500.0 5320200.0 False True 7859371.954694179 5055051.359785602 4769716.738961986 1.0 0.6431876985751215 0.6068826830511782 22.905982600122343 -13.999999999999998 0.3229647048012221 4.723699158282839 0.5999111131520461 0.9997000574768524 0.003072019121907228 18.24659021363574 0.18137635849148961 45.98223225086668 0.011949043458994972 1.0000000000000041e-14 13.999999999999998 -4.123788045130793 LITAHVEPLLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LITAHVEPLLAR 12 0 Q15306;Q15306-2 Q15306 IRF4 Interferon regulatory factor 4 0 16849700.0 4976300.0 2481900.0 9391500.0 False True 4818330.080388898 3472935.6129375203 6931584.411039197 1.0 0.7207757781212889 1.4385864594979623 22.200101798315362 -6.80120235118325 1.4508958540113805 0.8461755116690929 1.4488049559938876 0.8356950742636419 0.11975626894460224 0.21903769626518882 0.9101722666190686 0.06492857530436483 0.15089763833883876 1.5805114586889485e-07 6.80120235118325 0.6026294443247947 LITAHVEPLLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LITAHVEPLLAR 12 0 Q15306;Q15306-2 Q15306 IRF4 Interferon regulatory factor 4 0 24908500.0 5994900.0 9664500.0 9249100.0 False True 8211376.536080938 9237490.433772303 7064653.071193837 1.0 1.1249624704436099 0.8603494237722047 22.969192661645234 -6.778290379643398 1.5425656668327885 1.070913989689624 0.8583657861705413 0.7612832856534084 0.052808027367427096 0.25323942725896315 1.1901088431185447 0.02696683186258341 0.06372103945948931 1.666132823915504e-07 6.778290379643398 -0.21254820351908277 LITAHVEPLLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LITAHVEPLLAR 12 0 Q15306;Q15306-2 Q15306 IRF4 Interferon regulatory factor 4 0 10529500.0 4976300.0 2998800.0 2554400.0 False True 4138013.937469016 2982644.869184807 3088513.2297888384 1.0 0.7207914024110607 0.7463757436442816 21.98050707374964 -9.978573089258132 5.3433753843842595 1.0000009283111795 0.7335835730268402 0.9931309859087715 0.010444763574018821 1.1550883983285279e-07 2.2082765969387668e-08 0.010113134104858035 0.00337103294768333 1.0505746343313393e-10 9.978573089258132 -0.2664173552843393 LITAVVMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LITAVVMK 8 0 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3;H0Y8V7;H0Y9K1 D6REX3 SEC31A Protein transport protein Sec31A 0 8539600.0 2044200.0 2648600.0 3846800.0 False True 2679965.9960609577 2253439.2041619383 3448770.0371111967 1.0 0.8408461926285882 1.2868708193239151 21.3537832649231 -6.810237648562573 1.4136313614617981 0.9132860734500058 1.294708509834391 0.8604118582269905 0.06895451560690706 0.20648521038009435 0.8132304701171343 0.038354788750612004 0.08870896313042125 1.5479693289497842e-07 6.810237648562573 0.3814224363843851 LITAVVMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LITAVVMK 8 0 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3;H0Y8V7;H0Y9K1 D6REX3 SEC31A Protein transport protein Sec31A 0 6693400.0 2044200.0 1483600.0 3165600.0 False True 2799995.9824278383 1418049.646390872 2417950.4775784877 1.0 0.506447028956556 0.8635549810617642 21.41699332644599 -10.014595268684706 5.689981556050172 1.000000778707615 0.6850010050090366 0.5091851469764854 0.14578871095844514 1.4402322864183104e-06 2.4916143963176463e-07 0.14115966155774257 0.0470531041338609 9.669515887699514e-11 10.014595268684706 -0.31499977369857846 LITEDVQGK(ub)NCLTNFHGMDLTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LITEDVQGKNCLTNFHGMDLTR 22 1 P61247;D6RG13;D6RAT0;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7 P61247 RPS3A 40S ribosomal protein S3a 1 63088100.0 6405100.0 12056000.0 44627000.0 True False 9717004.975533012 9904512.606042063 35806453.889291085 1.0 1.0192968544300622 3.68492698927809 23.212080276901798 -6.908485759849615 0.9059688584087046 0.9134621129041457 4.018504142862654 0.9903378566720765 0.123967534209829 0.10542833726241091 0.14425573252282217 0.10074001277465423 0.2752607270178903 1.2345657948799463e-07 6.908485759849615 3.1050420299585086 up LITEDVQGK(ub)NCLTNFHGMDLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LITEDVQGKNCLTNFHGMDLTR 22 1 P61247;D6RG13;D6RAT0;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7 P61247 RPS3A 40S ribosomal protein S3a 1 69780100.0 6405100.0 17262000.0 46113000.0 True False 8291528.213396595 16301354.525482494 37720907.159336075 1.0 1.9660253340445069 4.5493310989873414 22.983206598994247 -6.954002858532397 0.5130202781440386 0.9536126693721924 5.675662592103739 0.9994791286787343 0.034195362223484134 0.08191710379768952 0.02961006596000567 0.039184101246813464 0.21325240719898766 1.1117244098717846e-07 6.954002858532397 4.722049922731547 LITK(ub)PSEGTTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LITKPSEGTTLR 12 1 F8W7U8;P49959-2;P49959;P49959-3 F8W7U8 MRE11A Double-strand break repair protein MRE11A 1 6587100.0 2581400.0 2674000.0 1331700.0 True False 2146548.4754099497 2659594.631252558 1610152.312914891 1.0 1.2390098158601457 0.7501122529307812 21.033587322796546 -6.773753207992097 1.5598989650965793 1.1364305127006988 0.7469509370364463 0.7447736048932636 0.10084186532976082 0.260403552014608 1.250953116405294 0.05093858109415351 0.12085171410543843 1.6836305284919226e-07 6.773753207992097 -0.3894795756642525 LITQTFSHHNQLAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LITQTFSHHNQLAQK 15 0 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 0 70618800.0 21682500.0 26778600.0 22157700.0 False True 28425967.473628677 22783337.262165252 19865033.75566671 1.0 0.801497338069559 0.6988340422923472 24.760706116078527 -13.999999999866697 0.08385926602452945 2.0470814799729578 0.41300281383255566 0.9998702640916333 0.0014238553394779704 12.220785155890171 0.08257861257848903 2.334308945957109 0.2584047488763645 1.0000000003069418e-14 13.999999999866697 -1.634078666140402 LITQTFSHHNQLAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LITQTFSHHNQLAQK 15 0 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 0 71241600.0 16531800.0 8930000.0 45779800.0 False True 16007007.05804982 12495795.569334794 33788697.01543869 1.0 0.7806453463797743 2.110869127058114 23.93220024650929 -6.8645570191421355 1.162424227191764 0.8792022004193504 2.1811460438201893 0.958946712808544 0.11798301886256024 0.1421848257157826 0.3625109066677356 0.0790001303855943 0.18547177537199352 1.365975723015426e-07 6.8645570191421355 1.301943843400839 up LITQTFSHHNQLAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LITQTFSHHNQLAQK 15 0 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 0 64999300.0 21682500.0 19595500.0 23721300.0 False True 29699106.197530396 18729706.01634695 18118817.49550879 1.0 0.6306488111721155 0.6100795550882755 24.82391617760142 -13.999999999999998 0.4113591246673457 7.699164110074917 0.6091857915400065 0.9998532087514088 0.00217063620633403 28.522319479255774 0.21277909898892797 171.24967489166858 0.005104206420461105 1.0000000000000041e-14 13.999999999999998 -7.089978318534911 LITQTFSHHNQLAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LITQTFSHHNQLAQK 15 0 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 0 40340600.0 16531800.0 15516400.0 8292400.0 False True 13746924.182917105 15432810.073435726 10026302.500274414 1.0 1.1226373163979197 0.7293487886354828 23.712605521943566 -6.822941632363262 1.3592834381940633 1.0659096960945111 0.720221924786851 0.8909782237166096 0.05425125388830519 0.1896865458203476 0.6878747684027722 0.03135844040591497 0.07221907428067058 1.503343996610298e-07 6.822941632363262 -0.34568777130766015 LITQTFSHHNQLAQK(ub)TR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LITQTFSHHNQLAQKTR 17 1 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 1 21448100.0 3280200.0 6316900.0 11851000.0 True False 4976303.214741907 5189599.840835036 9508644.655522186 1.0 1.042862465747918 1.9107848226276836 22.24664296336926 -6.917168744050174 0.8454417375423801 0.9788274495187592 2.0420273832225777 0.9933580960570992 0.034197349901365574 0.09986637062611406 0.11445168010769115 0.029031128587956884 0.08474369680485787 1.2101278500001412e-07 6.917168744050174 1.0631999337038185 LITQTFSHHNQLAQK(ub)TR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LITQTFSHHNQLAQKTR 17 1 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 1 4675800.0 1708700.0 1254600.0 1712500.0 True False 2340452.5658812523 1199167.623592605 1308042.7700445915 1.0 0.5123657027165948 0.5588845461399357 21.158356095467248 -10.22125926537572 8.374868339674212 1.0000001396425835 0.5356251251152913 0.9925299192187682 0.018991238301935047 4.954009895570269e-08 4.5804626958077855e-09 0.018388193170791493 0.006129395805604246 6.008149555348118e-11 10.22125926537572 -0.46437501452729224 LITVQVVPVAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LITVQVVPVAAR 12 0 Q13568-5;Q13568-4;Q13568;Q13568-3;Q13568-2 Q13568-5 IRF5 Interferon regulatory factor 5 0 8022400.0 2533700.0 3693400.0 1795300.0 False True 3321705.2363856994 3142359.1167604397 1609539.5777336278 1.0 0.9460078162081583 0.48455219930500065 21.663492625504578 -6.9288887862948005 0.7558718039723232 1.0073148225644057 0.39244834859905425 0.996314960460288 0.014041621641256889 0.09321951908447498 0.08054137366517557 0.012708899832548986 0.04201203299570909 1.1779075723190476e-07 6.9288887862948005 -0.6148664739653515 down LITVQVVPVAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LITVQVVPVAAR 12 0 Q13568-5;Q13568-4;Q13568;Q13568-3;Q13568-2 Q13568-5 IRF5 Interferon regulatory factor 5 0 6803500.0 2939100.0 1619400.0 2245000.0 False True 2845799.879282003 2266034.865059435 1656967.1514436454 1.0 0.7962734419790464 0.5822500603456696 21.440402782376708 -6.9705027157501265 0.24588333106494753 1.071455058518734 0.3008325454538059 0.9999860411527978 0.00063722336715337 0.07613992865218924 0.008444445580648274 0.0049098260041423045 0.020653027415867622 1.0702796901685273e-07 6.9705027157501265 -0.770622513064928 LITVQVVPVAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LITVQVVPVAAR 12 0 Q13568-5;Q13568-4;Q13568;Q13568-3;Q13568-2 Q13568-5 IRF5 Interferon regulatory factor 5 0 5982200.0 2939100.0 1542200.0 1500900.0 False True 2443991.87420678 1533891.8624972675 1814731.250622485 1.0 0.6276174150518018 0.7425275303795651 21.220808057810984 -10.61969561711179 9.595421528597766 1.0000706365956704 0.6850724727156838 0.9092132820854636 0.04691185813956471 7.09046706756977e-05 2.81022528369192e-06 0.045432288685829596 0.015140737109514912 2.4005147723619842e-11 10.61969561711179 -0.3149981638799866 LIVALMKPSR ddPTM_RPMI8226_Bortezomib_1h_R1 2 LIVALMKPSR 10 1 P08758;D6RBL5;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 0 94605000.0 22531900.0 29945900.0 42127200.0 False True 29539539.099229965 25478088.448203936 37768281.45663689 1.0 0.862507988449559 1.2785670531203863 24.816143980346645 -6.817644656293901 1.3818895330279881 0.9257069575710045 1.2872083415416369 0.878885820925142 0.060234217311158675 0.19657910584733954 0.7382283946702229 0.03425660898378517 0.07901539740775029 1.521792164705965e-07 6.817644656293901 0.36150138397063236 LIVALMKPSR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LIVALMKPSR 10 1 P08758;D6RBL5;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 0 57107860.0 22880270.0 14163190.0 20064400.0 False True 22153948.352876578 19818625.62706015 14808931.720902411 1.0 0.8945866132475118 0.6684556398263675 24.40106050797965 -6.958651333416617 0.4540412871984161 1.0069984563180234 0.5470185307633375 0.9997168620138392 0.0023273075753859514 0.0801864541575294 0.02293826853795136 0.0030412575725543086 0.01869414750728515 1.0998885134843678e-07 6.958651333416617 -0.4599799255546859 LIVALMKPSR ddPTM_RPMI8226_Bortezomib_8h_R1 2 LIVALMKPSR 10 1 P08758;D6RBL5;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 0 62367300.0 16620800.0 21201300.0 24545200.0 False True 25214968.743241947 17417762.36848702 19693830.46145664 1.0 0.6907707301106722 0.7810372744060978 24.587777101126928 -10.218634616568194 7.679972863423024 1.0000002635705474 0.7359040022583853 0.9194408179938609 0.03685116239468805 1.662921353190241e-07 1.689226745398731e-08 0.03568102018310086 0.011893661520251005 6.044569611351625e-11 10.218634616568194 -0.26409626131216213 LIVALMKPSR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LIVALMKPSR 10 1 P08758;D6RBL5;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 0 83704000.0 22531900.0 26469300.0 34702800.0 False True 30862552.33170229 25299798.80373006 26506713.3666006 1.0 0.819757177948691 0.8588632943158323 24.879354041869536 -10.572187629251127 6.371762749086161 1.0003020433545822 0.8393102361322617 0.9574696189262526 0.015965005153566348 6.862886930540058e-05 4.607891576488609e-06 0.01548680324621071 0.005152683256823177 2.6780110875209067e-11 10.572187629251127 -0.16099180722232043 LIVALMKPSR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LIVALMKPSR 10 1 P08758;D6RBL5;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 0 47712030.0 22880270.0 12059040.0 12772720.0 False True 19025958.27282403 11994075.55798798 15443436.69761531 1.0 0.63040585845917 0.8117034882639336 24.181465783413927 -10.109285143139916 5.0345555492904905 1.00000914461876 0.7210546733607637 0.7594074426480988 0.0740144474356812 7.597344838921272e-06 1.3440169721281691e-06 0.0716665291372283 0.02388806019103621 7.775258860875583e-11 10.109285143139916 -0.27895447125799633 LIVALMKPSR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LIVALMKPSR 10 1 P08758;D6RBL5;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 0 80327900.0 16620800.0 35539500.0 28167600.0 False True 21515953.24494887 33561695.58326867 23041385.823982712 1.0 1.5598516691863367 1.070897745578247 24.358903423219378 -10.256384181328746 3.6116823063160655 0.9993845906030543 1.3153747065546366 0.3567882441104345 0.19961460535627562 71107939.49394174 107700872.24522744 503342.0312273037 0.07305147080673016 5.5413530233782407e-11 10.256384181328746 0.31599011595158233 LIVDEAINEDNSVVSLSQPK(ub)MDELQLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIVDEAINEDNSVVSLSQPKMDELQLFR 28 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 53667000.0 22752000.0 13048000.0 17867000.0 True False 29452912.50896928 12321867.329886178 14615389.330901425 1.0 0.41835819551407033 0.496229000322145 24.811906969047747 -10.627623259671456 6.569375975674312 1.0019421471548233 0.4572935979184959 0.9847936164889697 0.03179062293994165 0.0009067404595903321 5.1397342571193366e-05 0.030864590982351826 0.010260379434329453 2.3570931205555213e-11 10.627623259671456 -0.5446485492363274 LIVENLSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIVENLSSR 9 0 Q08170;A0A0D9SEM4;B4DJK0;B4DUA4;A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247;Q13243-3;Q13243 Q08170;A0A590UJK4;Q13243-3 SRSF4;SRSF5;SRSF6 Serine/arginine-rich splicing factor 4;Serine/arginine-rich splicing factor 6;Serine/arginine-rich splicing factor 5 0 14268200.0 2459200.0 5146300.0 6662700.0 False True 3224035.014926678 4378492.100120286 5973307.717131313 1.0 1.3580783334699185 1.8527428174557712 21.62043598179637 -6.966589393112914 0.3296369085601248 0.9394784026283668 2.2875274869143194 0.9999422583136073 0.0026566555466659048 0.0774256716846783 0.012980183024075777 0.007227301378508863 0.04315838051544361 1.0799673026633287e-07 6.966589393112914 1.3480490842859525 LIVENLSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIVENLSSR 9 0 Q08170;A0A0D9SEM4;B4DJK0;B4DUA4;A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247;Q13243-3;Q13243 Q08170;A0A590UJK4;Q13243-3 SRSF4;SRSF5;SRSF6 Serine/arginine-rich splicing factor 4;Serine/arginine-rich splicing factor 6;Serine/arginine-rich splicing factor 5 0 11575800.0 5090000.0 2133200.0 4352600.0 False True 4928420.73612514 2984997.8844910436 3212523.484798937 1.0 0.605670263216596 0.651836289310947 22.23269399256705 -10.684484021242804 10.29350084147517 1.000209845005229 0.6287532764269514 0.9885350255311267 0.018847201230528864 9.081244089634063e-05 2.783582323564051e-06 0.018258587219676412 0.00608290804070485 2.0678354612487943e-11 10.684484021242804 -0.3714565685782776 LIVENLSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIVENLSSR 9 0 Q08170;A0A0D9SEM4;B4DJK0;B4DUA4;A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247;Q13243-3;Q13243 Q08170;A0A590UJK4;Q13243-3 SRSF4;SRSF5;SRSF6 Serine/arginine-rich splicing factor 4;Serine/arginine-rich splicing factor 6;Serine/arginine-rich splicing factor 5 0 14267700.0 2459200.0 5944900.0 5863600.0 False True 3368432.6973811514 5682234.660844632 4478738.444632686 1.0 1.6869075832396438 1.3296208792043736 21.68364604331926 -10.041739541861467 4.280147285918494 0.9999615992877189 1.5082642309805487 0.7296027166285488 0.14586168651023756 14593193.120061405 5706231.888182232 5279.917635160708 0.04993233464069342 9.083651379776057e-11 10.041739541861467 0.5083026316928299 LIVGTAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIVGTAGR 8 0 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 2599680.0 549280.0 1012000.0 1038400.0 False True 720111.3992350867 861013.5447451037 930956.3290361499 1.0 1.195667150471004 1.2927948787160235 19.45786057917549 -13.99999999999998 0.09126898272081406 0.0034789490278039742 1.5308148816860143 0.9998364262994768 0.0015573598550071097 12.152616991679983 0.08808800155750582 2.339631716912028 0.21361953399925288 1.000000000000045e-14 13.99999999999998 1.5273359326582103 LIVGTAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIVGTAGR 8 0 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 3558580.0 549280.0 1444200.0 1565100.0 False True 752363.6597338639 1380390.4686692492 1195455.6142463016 1.0 1.8347383619744997 1.5889332223584192 19.521070640698383 -10.144672388069173 4.551760688352178 0.9999093356812834 1.711835792163126 0.9179111473019271 0.10034952808597697 70160899.42289309 12.09581125651635 66930.3295276259 0.034352312597268155 7.166838399204595e-11 10.144672388069173 0.7119264564818426 LIVIGFISGYQTPTGLSPVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIVIGFISGYQTPTGLSPVK 20 0 Q8N4Q0-2;Q8N4Q0 Q8N4Q0-2 ZADH2 Zinc-binding alcohol dehydrogenase domain-containing protein 2 0 31465200.0 7990200.0 11862000.0 11613000.0 False True 12121717.561865373 9745133.42177099 9317685.459841283 1.0 0.8039399839201783 0.7686769974870965 23.531090797215928 -13.999999999999998 0.2412983774653488 2.3059421284437724 0.753276525389013 0.9995271300794387 0.0022127917821309594 13.669656027086452 0.1554667936920243 8.60852169214097 0.017100419769972196 1.0000000000000041e-14 13.999999999999998 -1.5526656030547594 LIVIGFISGYQTPTGLSPVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIVIGFISGYQTPTGLSPVK 20 0 Q8N4Q0-2;Q8N4Q0 Q8N4Q0-2 ZADH2 Zinc-binding alcohol dehydrogenase domain-containing protein 2 0 25770700.0 7990200.0 9590400.0 8190100.0 False True 10343471.41038883 9056685.809360866 6699585.837522576 1.0 0.8755944160356517 0.6477115439980441 23.302217119308377 -6.96172607578982 0.41038313759101674 1.01117888253869 0.5036648299363512 0.9998289548403083 0.001907800648015931 0.07909019400686648 0.0188948302237824 0.002934718600379733 0.01902415987983596 1.0921289619097282e-07 6.96172607578982 -0.5075140526023388 LIVNK(ub)NAGETLLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIVNKNAGETLLQR 14 1 H7C231;Q6W2J9-4;Q6W2J9-2;Q6W2J9;H7BZ37;H7C2V9;A0A075B6Q3;Q5H9F3-3 H7C231 BCOR;BCORL1 BCL-6 corepressor 1 490230000.0 168470000.0 210320000.0 111440000.0 True False 220865801.46580082 178941075.82093886 99909257.80796282 1.0 0.8101800941267331 0.45235277324467504 27.71859481031715 -6.961185438906664 0.41839213481855064 1.0160930567858346 0.2329771970589296 0.9998116679546999 0.0031159765108139423 0.07928034069542769 0.01958655381064029 0.004624280467187362 0.029799822433340013 1.0934893587986118e-07 6.961185438906664 -0.783115859726905 down LIVNK(ub)NAGETLLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIVNKNAGETLLQR 14 1 H7C231;Q6W2J9-4;Q6W2J9-2;Q6W2J9;H7BZ37;H7C2V9;A0A075B6Q3;Q5H9F3-3 H7C231 BCOR;BCORL1 BCL-6 corepressor 1 1230570000.0 542540000.0 371960000.0 316070000.0 True False 525317364.67138195 520485567.74577576 233281785.10324904 1.0 0.9908021374305249 0.4440778104664045 28.968614033504398 -6.910552701714217 0.8919632077552972 1.016633203726962 0.3725813310942859 0.9911284571686927 0.02448189023351722 0.10405365575877291 0.13679341769491937 0.02009858485057443 0.055695912688046474 1.2287040740688361e-07 6.910552701714217 -0.6440518726326763 down LIVNK(ub)NAGETLLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIVNKNAGETLLQR 14 1 H7C231;Q6W2J9-4;Q6W2J9-2;Q6W2J9;H7BZ37;H7C2V9;A0A075B6Q3;Q5H9F3-3 H7C231 BCOR;BCORL1 BCL-6 corepressor 1 766009000.0 214330000.0 189756000.0 361923000.0 True False 325154279.6218625 155892559.22960493 290388760.4135136 1.0 0.4794418188525763 0.8930799273231791 28.276549171493418 -9.922351323442554 6.743251522901646 1.0000000169712027 0.6862608730878761 0.4340914726343317 0.1688670506538435 4.32164199465562e-08 6.864911823835964e-09 0.16350482847200423 0.05450160624212294 1.195772816985436e-10 9.922351323442554 -0.3137391438833266 LIVNK(ub)NAGETLLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIVNKNAGETLLQR 14 1 H7C231;Q6W2J9-4;Q6W2J9-2;Q6W2J9;H7BZ37;H7C2V9;A0A075B6Q3;Q5H9F3-3 H7C231 BCOR;BCORL1 BCL-6 corepressor 1 521091000.0 168470000.0 201221000.0 151400000.0 True False 230757911.73056376 192330390.87113643 115642438.18087661 1.0 0.8334725749109055 0.5011418127058732 27.78180487184004 -6.960087658140928 0.43420068274884344 1.0126273707407483 0.3091539765382438 0.9997734255911958 0.0031214640080220444 0.07966987831288232 0.021016091585220144 0.004352128939584824 0.027567883212221693 1.096256904957288e-07 6.960087658140928 -0.7034733942025044 LIVNK(ub)NAGETLLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIVNKNAGETLLQR 14 1 H7C231;Q6W2J9-4;Q6W2J9-2;Q6W2J9;H7BZ37;H7C2V9;A0A075B6Q3;Q5H9F3-3 H7C231 BCOR;BCORL1 BCL-6 corepressor 1 1213815300.0 542540000.0 557745000.0 113530300.0 True False 451146048.59723973 554740316.9812857 137268960.82520208 1.0 1.2296246829738493 0.30426723508277653 28.749019308938674 -6.841020809689748 1.2775926375342603 1.1221435243926656 0.2732003686965208 0.9262075288832678 0.10687333655191092 0.16760580354515137 0.5309688931976622 0.06558213265397907 0.15113684235184277 1.4420462526637797e-07 6.841020809689748 -0.8489431556961449 down LIVNK(ub)NAGETLLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIVNKNAGETLLQR 14 1 H7C231;Q6W2J9-4;Q6W2J9-2;Q6W2J9;H7BZ37;H7C2V9;A0A075B6Q3;Q5H9F3-3 H7C231 BCOR;BCORL1 BCL-6 corepressor 1 631541000.0 214330000.0 252132000.0 165079000.0 True False 277454410.0759227 238100632.55815953 135036315.8535777 1.0 0.8581612831203713 0.48669731296261004 28.047675493585867 -6.9544581683467275 0.5075462729160374 1.0069768109924784 0.3216530857318221 0.9995062951879631 0.004808989606692769 0.08174342115776355 0.028924339147798434 0.005562767347604356 0.030653105969253656 1.1105595003184478e-07 6.9544581683467275 -0.6853237252606563 down LIVNVNDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIVNVNDLR 9 0 P25205;P25205-2 P25205 MCM3 DNA replication licensing factor MCM3 0 25840300.0 8386100.0 7822700.0 9631500.0 False True 10994258.311107932 6655583.652645773 8634924.771871815 1.0 0.6053690448514726 0.7854031192943329 23.39024694535043 -10.049955554352863 4.7091459471756325 1.0000093302164528 0.6953860820634871 0.7924044241947783 0.0734986031459902 101815760.835994 0.25269764257043353 11293.480477600013 0.02516052680067027 8.913421533192521e-11 10.049955554352863 -0.3046232481529657 LIVNVNDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIVNVNDLR 9 0 P25205;P25205-2 P25205 MCM3 DNA replication licensing factor MCM3 0 17402100.0 7071200.0 3062300.0 7268600.0 False True 6846728.626579184 4285092.359683534 5364735.606674078 1.0 0.6258598220248851 0.7835472821060894 22.70698340096743 -10.159378365731168 5.280625079043361 1.0000107460915446 0.7047035534081751 0.8238150329645466 0.06437563600621711 8.144686871575876e-06 1.296581910626506e-06 0.06233370866588332 0.020777147179396997 6.928219431632766e-11 10.159378365731168 -0.29530719268336947 LIVNVNDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIVNVNDLR 9 0 P25205;P25205-2 P25205 MCM3 DNA replication licensing factor MCM3 0 33735900.0 4121800.0 23858000.0 5756100.0 False True 6253071.943943414 19600353.496595196 4618404.312011744 1.0 3.134515910308638 0.7385816688843677 22.576133685417503 -6.67164961679481 1.931045440315965 2.3604144887455534 0.7480385690091452 0.2867404383356553 0.9063317004498966 0.4572324347685297 3.288479629948559 0.3775998444596405 1.0068632004314748 2.1298566940030098e-07 6.67164961679481 -1.612375919736408 LIVNVNDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIVNVNDLR 9 0 P25205;P25205-2 P25205 MCM3 DNA replication licensing factor MCM3 0 29132400.0 8386100.0 8826300.0 11920000.0 False True 11486667.795831198 8436324.881329043 9104741.500106018 1.0 0.7344449261770065 0.7926355721204333 23.45345700687332 -10.806913323025427 7.1264202408972155 1.0099481054687287 0.7635402491497646 0.9565527670712555 0.023756231727391934 0.0038115207762694377 0.0001032710454724319 0.02334910410248138 0.0076672908207361026 1.5598637911084797e-11 10.806913323025427 -0.2464078563189641 LIVNVNDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIVNVNDLR 9 0 P25205;P25205-2 P25205 MCM3 DNA replication licensing factor MCM3 0 13850200.0 7071200.0 3840300.0 2938700.0 False True 5880016.1072746655 3819611.541660133 3553168.5829864033 1.0 0.6495920201535789 0.6042787159359101 22.487388676401707 -13.999999999999998 0.2883640776633086 3.991799772319497 0.591725891616039 0.9996238017158415 0.0034298498821665364 15.869287768779811 0.1702580860806621 28.138008435853905 0.017241166893318272 1.0000000000000041e-14 13.999999999999998 -3.400073880703458 LIVNVNDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIVNVNDLR 9 0 P25205;P25205-2 P25205 MCM3 DNA replication licensing factor MCM3 0 14150500.0 4121800.0 6140000.0 3888700.0 False True 5335751.352824791 5798303.602506223 3180996.5014314875 1.0 1.0866892437625588 0.5961665548278297 22.347260007509952 -6.861243922737308 1.1793238257979937 1.0472034533409702 0.5718299759395861 0.9551415017320185 0.04527228394840719 0.1455319877492351 0.3838894467635298 0.02992392031100666 0.06995726526301795 1.3764361724410306e-07 6.861243922737308 -0.47537347740138414 LIVSAWYNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIVSAWYNK 9 0 Q9UJC3;Q9UJC3-2 Q9UJC3 HOOK1 Protein Hook homolog 1 0 17320200.0 4230200.0 7227000.0 5863000.0 False True 5476077.289708246 6824811.0969564235 4795994.159460184 1.0 1.2462956119671633 0.87580833975331 22.38471137835459 -6.72746889824342 1.7322441900696026 1.148633727749191 0.8761198782144064 0.5475874471611613 0.10355909222934857 0.3410039589440538 2.0033890872198206 0.047396643171540416 0.11795973854406558 1.8729712100011152e-07 6.72746889824342 -0.2725138495347845 LIYAGK(ub)ILNDDTALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIYAGKILNDDTALK 15 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 151408600.0 41869900.0 89610600.0 19928100.0 True False 54891844.36868843 76241047.77938308 17866131.375833303 1.0 1.3889321566114607 0.3254787952802795 25.7100884789632 -6.807701389811003 1.423920124262434 1.212548903730459 0.3077916361091934 0.8538085841125702 0.16798175250415484 0.2099483839189121 0.8393607477433063 0.09276791294385457 0.21484852372401197 1.557035843133004e-07 6.807701389811003 -0.9047572676212656 down LIYAGK(ub)ILNDDTALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIYAGKILNDDTALK 15 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 218491300.0 99286000.0 86482400.0 32722900.0 True False 96134220.27640863 121015273.31975819 24151790.824042466 1.0 1.2588157783129739 0.2512299028857815 26.518546733453775 -6.838555717830428 1.289158770247109 1.1377185268494943 0.21904092442414141 0.9219288232568505 0.11937844389016486 0.17049421240969687 0.551044545315102 0.07263025638234062 0.16726016932044463 1.450254701875827e-07 6.838555717830428 -0.9186776024253529 down LIYAGK(ub)ILNDDTALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIYAGKILNDDTALK 15 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 239275300.0 143007000.0 73110300.0 23158000.0 True False 216952074.21212006 60063195.75161887 18580811.149488032 1.0 0.2768500645580066 0.08564477300789047 27.69280113848349 -11.281156156761815 0.2487140980427011 2.174236555295591 1.9125232585684254e-14 0.9992390553545222 0.010862456183388464 3.5858164616627923 0.1395709916237746 2.407456420745322 0.08778930767258067 5.234122024400942e-12 11.281156156761815 -2.174236555295572 LIYAGK(ub)ILNDDTALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIYAGKILNDDTALK 15 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 132935800.0 41869900.0 70181900.0 20884000.0 True False 57350333.52150257 67081031.59749233 15951629.319481032 1.0 1.1696711680384804 0.27814361905149565 25.773298540486092 -6.857437968349176 1.1986698033384209 1.0914968900942983 0.23704852579057126 0.950444390514243 0.08604698290464424 0.14946304622759116 0.40954140752919305 0.05604576795648665 0.13046831165347966 1.3885516269746245e-07 6.857437968349176 -0.8544483643037271 down LIYAGK(ub)ILNDDTALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIYAGKILNDDTALK 15 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 224523600.0 99286000.0 109571000.0 15666600.0 True False 82560708.1155776 108980719.2748594 18942413.625825956 1.0 1.32000708039345 0.22943618166777682 26.29895200888805 -6.828139861625012 1.3361879203658205 1.1712217335410309 0.20118552916934096 0.9021102492798105 0.14320648967829805 0.18311382804149196 0.6400423721027292 0.08416570955996326 0.19371069822335454 1.4854571837261437e-07 6.828139861625012 -0.9700362043716899 down LIYAGK(ub)ILNDDTALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIYAGKILNDDTALK 15 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 232812000.0 143007000.0 74654000.0 15151000.0 True False 185125380.58940646 70499439.2738599 12393673.46238807 1.0 0.38081995590989287 0.06694745703116886 27.46392746057594 -8.685289443974234 0.3826897134898361 1.128954295642671 2.4019973930272218e-17 0.997278230340432 0.020224181252416557 0.2785007246494497 0.12645270554935092 0.13018661157946157 0.07848349753155447 2.0640041017778167e-09 8.685289443974234 -1.128954295642671 LIYAGK(ub)ILSDDVPIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIYAGKILSDDVPIR 15 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 499092000.0 261620000.0 180510000.0 56962000.0 True False 342986353.53168416 153578611.62246892 51068118.65808666 1.0 0.44776886905584057 0.14889256710141713 28.353575935835707 -8.738243543955287 0.2924284108014683 1.217115459864041 3.6587674488419456e-19 0.998764968785148 0.012389925243279297 0.292290455414948 0.09041579930238126 0.16550513060592123 0.09893333330948222 1.8270753402508803e-09 8.738243543955287 -1.217115459864041 LIYAGK(ub)ILSDDVPIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIYAGKILSDDVPIR 15 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 765220000.0 347050000.0 229320000.0 188850000.0 True False 336033087.71556515 320888671.88800156 139384519.62144 1.0 0.9549317719557946 0.4147940328406644 28.32402805499856 -6.923411867264612 0.799014030334341 1.010516922752223 0.3204687018068201 0.9950773764352583 0.01865475509880933 0.09620571487037569 0.09551477284074099 0.016370531971278652 0.05075808519827264 1.1928563113516728e-07 6.923411867264612 -0.690048220945403 down LIYAGK(ub)ILSDDVPIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIYAGKILSDDVPIR 15 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 962250000.0 516410000.0 279090000.0 166750000.0 True False 783431724.6280302 229284208.95987698 133791789.41087864 1.0 0.2926664848410882 0.170776578487937 29.5452323096965 -13.999999999999998 0.24737313978458203 5.854792967237913 0.12052719084725219 0.999537821552218 0.007859198484768968 13.89537076043104 0.1573890462226311 33.468788548278745 0.05708500875611422 1.0000000000000041e-14 13.999999999999998 -5.734265776390661 LIYAGK(ub)ILSDDVPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIYAGKILSDDVPIR 15 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 523225000.0 261620000.0 180610000.0 80995000.0 True False 358347984.014662 172630053.00259882 61865649.14438634 1.0 0.481738591267017 0.17264126464809432 28.4167859973586 -8.531009498759172 0.287504875029779 1.1940555859349868 3.497643413270606e-24 0.9989246235545047 0.011193760039128762 0.1824380039271758 0.07954704639164598 0.12871138233177157 0.1003724281447333 2.9443572349926296e-09 8.531009498759172 -1.1940555859349868 LIYAGK(ub)ILSDDVPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIYAGKILSDDVPIR 15 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 688511000.0 347050000.0 248480000.0 92981000.0 True False 288587451.9218338 247141388.9205819 112422897.20443003 1.0 0.8563830037472389 0.3895626662065704 28.104433330432837 -6.94963538603784 0.5628312811801116 1.006017308737293 0.2175095312312465 0.9991723656254048 0.0074969174831803235 0.08363246729294994 0.036570695066224956 0.008009062894190821 0.038829750807743 1.1229608456787395e-07 6.94963538603784 -0.7885077775060465 down LIYAGK(ub)ILSDDVPIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIYAGKILSDDVPIR 15 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 897260000.0 516410000.0 276210000.0 104640000.0 True False 668502924.9629403 260838670.69189656 85596593.69706868 1.0 0.3901832900826225 0.12804221268263544 29.31635863178895 -9.368637138016261 0.2736470068561014 1.3570119005978942 2.766402161107032e-22 0.9988737697803594 0.012258760664836929 0.7748579906945736 0.10655899438687995 0.35230478991670305 0.10011761344365254 4.279202730296978e-10 9.368637138016261 -1.3570119005978942 LIYAGK(ub)ILSDDVPIRDYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIYAGKILSDDVPIRDYR 18 2 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 64696000.0 19025000.0 20142000.0 25529000.0 True False 24628237.538815953 19021079.993758995 20882983.9496604 1.0 0.772328103616036 0.8479284770884336 24.553810052706602 -10.45963477382965 8.441791086785065 1.0000052096663614 0.8101282903522348 0.893733434648368 0.030863723228535884 3.0262564919691577e-06 1.9370728953237314e-07 0.029884491028163113 0.009961223838839543 3.470285664217082e-11 10.45963477382965 -0.18987691931412665 LIYDTK(ub)GR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIYDTKGR 8 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 1 24762200.0 8386100.0 6746600.0 9629500.0 True False 10994258.311107932 5740033.578040825 8633131.712686457 1.0 0.5220937525400366 0.7852400287852127 23.39024694535043 -10.108161210541287 5.326713583676095 1.0000061506953666 0.6536668906623875 0.6978465128021037 0.10742901741985796 7.847141762585636e-06 1.3138361007562603e-06 0.10401954583748824 0.03467256628042436 7.795406905346408e-11 10.108161210541287 -0.3463392600329791 LIYDTK(ub)GR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIYDTKGR 8 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 1 38970300.0 7897400.0 8932200.0 22140700.0 True False 7646701.359818196 12498874.04080765 16341386.463237587 1.0 1.6345445509990226 2.1370504344668317 22.866406100379095 -6.973754758781308 0.14230573029403926 0.3487862790388588 3.4359404131146585 0.9999988449391657 0.000499978639345731 0.07510218593052814 0.004318533146851462 0.027730504230539504 0.06477025915095878 1.0622952540667599e-07 6.973754758781308 3.0871541340757997 LIYDTK(ub)GR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIYDTKGR 8 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 1 68992500.0 17109000.0 14052000.0 37831500.0 True False 25955603.835442733 11544310.811222889 30354087.442864466 1.0 0.4447714214014537 1.1694618100702996 24.629542715426748 -6.702001903118955 1.8238042222352233 0.6558989955382533 1.1673824099688377 0.4270235067589929 0.23428482806199485 0.3913870928091258 2.5323789017344773 0.10243028289107432 0.262767439193309 1.9860862141231394e-07 6.702001903118955 0.5114834144305844 LIYDTK(ub)GR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIYDTKGR 8 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 1 22552950.0 8386100.0 5239050.0 8927800.0 True False 11486667.795831198 5007571.447778449 6819237.513812612 1.0 0.43594639775303884 0.5936654245618112 23.45345700687332 -10.649301844038671 10.063888587531258 1.0001433931257266 0.5148059111575126 0.9265695067733518 0.06438852306830548 0.00020721835089736908 7.2209763641978265e-06 0.062361655102377116 0.02078130646086994 2.2423229192477757e-11 10.649301844038671 -0.485337481968214 LIYDTK(ub)GR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIYDTKGR 8 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 1 33152600.0 7897400.0 16449800.0 8805400.0 True False 6567038.014140587 16361181.662370335 10646568.428430408 1.0 2.4914096168075073 1.6212131566020331 22.64681137581337 -9.97791210416859 5.984838383037562 0.999999193209081 2.0563113867049463 0.6626935174878309 0.3552562172472168 3.824486461320148e-06 6.534618082786263e-07 0.34397561462219095 0.1146584510861678 1.0521747994409453e-10 9.97791210416859 1.0563121934958652 LIYDTK(ub)GR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIYDTKGR 8 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 1 50619900.0 17109000.0 12658200.0 20852700.0 True False 22147937.768809587 11953760.042547911 17057722.56677049 1.0 0.5397233894788213 0.7701720469339802 24.400669037519197 -10.176923099658941 5.31624579320657 1.000012636807064 0.6549477182103739 0.7493254233445013 0.09408027045247308 1.6200456506696005e-05 2.508175088932087e-06 0.09109666263859395 0.03036427672141792 6.653909662693907e-11 10.176923099658941 -0.3450649185966902 LIYFQLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LIYFQLHR 8 0 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 33234300.0 7618600.0 18026000.0 7589700.0 False True 9988058.378627345 15336591.064797668 6804390.64954321 1.0 1.5354927337644746 0.6812525910044125 23.251772822940122 -6.737204813853267 1.6967127541590241 1.3196349073185978 0.6810275370922428 0.5924536347993639 0.22501083167151217 0.3228811146389039 1.8239691134377078 0.10495506051953057 0.25836639431393926 1.831450504189617e-07 6.737204813853267 -0.6386073702263549 LIYFQLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIYFQLHR 8 0 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 37615400.0 12856000.0 15879000.0 8880400.0 False True 12447893.317018604 22219567.507891055 6554356.833710539 1.0 1.7850062610604753 0.5265434613541798 23.569398265279084 -6.738009167421122 1.6938249520570208 1.468139093627699 0.5260954824295468 0.5960690086296883 0.329844917992779 0.3214155461628373 1.8098455139282723 0.15409804900055665 0.3789957061622801 1.82806162760811e-07 6.738009167421122 -0.9420436111981522 LIYFQLHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIYFQLHR 8 0 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 600650000.0 252160000.0 161500000.0 186990000.0 False True 382545155.36531854 132679063.19474061 150031344.53937146 1.0 0.34683242313717527 0.39219250965574576 28.51105481167962 -9.833011629253916 6.6999962835915365 1.0000000095688282 0.3695124663964231 0.9961330070777707 0.01851817777663405 2.6492447107496923e-09 4.785316819717524e-10 0.01793014879987288 0.005976716177564414 1.4688869442222654e-10 9.833011629253916 -0.6304875431724051 LIYFQLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIYFQLHR 8 0 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 52351600.0 7618600.0 24657000.0 20076000.0 False True 10435402.304923559 23567572.210204717 15334462.278198682 1.0 2.2584248811457157 1.4694653670384785 23.314982884463014 -10.277088068012262 5.476093805687025 0.9999710612523592 1.8639451237239975 0.6152110889698492 0.3220913751377408 0.0003736096491781092 4.9320767003280884e-05 0.31189747176913785 0.10395454398199663 5.283381023489868e-11 10.277088068012262 0.8639740624716382 LIYFQLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIYFQLHR 8 0 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 56108100.0 12856000.0 34932000.0 8320100.0 False True 10690333.617366651 34743814.382540904 10059794.4422041 1.0 3.250021526559182 0.9410178206096179 23.34980354071336 -6.65206435102987 2.0010745504393364 2.457631325605972 0.9507009531606937 0.20253471301013848 0.9598439826573162 0.5034683204885425 3.86659218027709 0.3886887236111711 1.0633368390279743 2.2281049782017244e-07 6.65206435102987 -1.5069303724452783 LIYFQLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIYFQLHR 8 0 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 608270000.0 252160000.0 206700000.0 149410000.0 False True 326426090.8167059 195196963.2960969 122218913.07606101 1.0 0.5979821122990548 0.37441527045302614 28.28218113377207 -9.66850733352912 0.14281046479859083 1.6449186073760094 1.3275317470555644e-10 0.9998050336852017 0.003614107531208608 1.1395405322681893 0.05959663204835579 0.4857917210922911 0.19831603053113317 2.1453228894269983e-10 9.66850733352912 -1.6449186072432562 LIYQTLSWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIYQTLSWK 9 0 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;O95453-3;A0A494C0Q6;A0A494C0K5;A0A494C1G3;A0A494C002;H3BRK1;F5H1Z4 O95453 PARN Poly(A)-specific ribonuclease PARN 0 6328600.0 2834600.0 1171300.0 2322700.0 False True 2744617.1745815943 1639006.198248806 1714315.19049361 1.0 0.5971711513824021 0.6246099479265083 21.388173502216244 -10.73931134262851 6.867036017998003 1.006308314905228 0.6108905496545373 0.9962843802575246 0.011201841781517105 0.0010885759703003245 4.132483031385121e-05 0.010913393649466908 0.003615378888888842 1.8225886330193506e-11 10.73931134262851 -0.39541776525069083 LIYQTLSWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIYQTLSWK 9 0 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;O95453-3;A0A494C0Q6;A0A494C0K5;A0A494C1G3;A0A494C002;H3BRK1;F5H1Z4 O95453 PARN Poly(A)-specific ribonuclease PARN 0 6245500.0 2834600.0 1611200.0 1799700.0 False True 2357095.494071838 1602520.1458018397 2176008.94912738 1.0 0.6798706924824316 0.9231738614748974 21.16857877765052 -10.351940172897192 5.573376125840247 1.0000485099246994 0.8015222769786627 0.470140386634733 0.09932810280562085 5.988648348444826e-05 6.963503612769253e-06 0.09619749061393978 0.032058007331378084 4.446925227555098e-11 10.351940172897192 -0.19852623294603666 LIYSGK(ub)QMNDEK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LIYSGKQMNDEK 12 1 Q15843;S4R3E9 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 367189400.0 98488300.0 113753500.0 154947600.0 True False 129119115.06205395 96781921.20767 138915108.71433157 1.0 0.7495553323855816 1.0758678809684354 26.944127355126167 -6.701710241005344 1.8253461378919142 0.8447399332211614 1.0749104104485854 0.4254570246690964 0.10568353634663638 0.39196389589707276 2.5403192271332404 0.04617504493737972 0.1184746119121646 1.987420471594898e-07 6.701710241005344 0.230170477227424 LIYSGK(ub)QMNDEK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LIYSGKQMNDEK 12 1 Q15843;S4R3E9 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 678426100.0 153151200.0 133103900.0 392171000.0 True False 148289498.98672852 186252981.39766893 289449650.2221852 1.0 1.2560092432056704 1.9519227740333123 27.143841197106088 -6.953643957495475 0.517296837035991 0.9879227126464976 2.250922401467266 0.9994570813528371 0.00937185879861193 0.08205471210825334 0.0301560560725299 0.01066339204704489 0.057468182920650604 1.1126435188450088e-07 6.953643957495475 1.2629996888207686 LIYSGK(ub)QMNDEK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LIYSGKQMNDEK 12 1 Q15843;S4R3E9 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 1996234300.0 370681000.0 691315000.0 934238300.0 True False 562350177.4110563 567944436.9812518 749585690.5138065 1.0 1.0099480000094432 1.3329518165438192 29.06689354058967 -6.913471185658312 0.8717796286126482 0.9910630846109556 1.3779463829022882 0.9921663734754477 0.013688926270838932 0.10216726866900162 0.12665398614270015 0.011403274153908498 0.03228856686976985 1.2204747934773026e-07 6.913471185658312 0.3868832982913326 LIYSGK(ub)QMNDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LIYSGKQMNDEK 12 1 Q15843;S4R3E9 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 390785200.0 98488300.0 85060600.0 207236300.0 True False 134902086.05623126 81302341.43421105 158291354.10557202 1.0 0.6026766806283617 1.1733795876187667 27.007337416649058 -6.719462858391312 1.7610205165646553 0.7581414638724528 1.1724784187163557 0.5101133824276322 0.16720564089788806 0.3563471494138034 2.1593938868897964 0.07539512304716145 0.1894059035957291 1.9078188769547115e-07 6.719462858391312 0.41433695484390287 LIYSGK(ub)QMNDEK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LIYSGKQMNDEK 12 1 Q15843;S4R3E9 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 619180900.0 153151200.0 228414100.0 237615600.0 True False 127352008.54854119 227183587.90665105 287299923.34959805 1.0 1.7839026686419186 2.2559512537259394 26.924246472540364 -8.927857050039744 0.1510865880671147 1.3046788929553884e-19 3.0609434809628744 0.9998438931207891 0.006471804565466721 0.42154658794961164 0.04790161544160257 0.5395426319067306 0.3485842479265857 1.1807092073850134e-09 8.927857050039744 3.0609434809628744 LIYSGK(ub)QMNDEK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LIYSGKQMNDEK 12 1 Q15843;S4R3E9 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 2233198500.0 370681000.0 724495500.0 1138022000.0 True False 479853861.71489376 684176688.5422721 930913673.0917957 1.0 1.4258021933952407 1.939994126055195 28.83801986268212 -6.968610102186738 0.28946783090697054 0.898888722217249 2.482782160156122 0.9999694188379775 0.002125269316754468 0.07675634540782413 0.010636396034854707 0.009008970699005001 0.04665799797375418 1.0749540438678196e-07 6.968610102186738 1.583893437938873 LIYSGK(ub)QMNDEK(ub)TAADYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LIYSGKQMNDEKTAADYK 18 2 Q15843;S4R3E9 Q15843 NEDD8;NEDD8-MDP1 NEDD8 2 15778900.0 1743800.0 1929100.0 12106000.0 True False 1688444.023507859 2699399.6901236027 8935075.427784752 1.0 1.5987498860136409 5.2918991114798795 20.687262920214568 -6.935252557009102 0.702336745378271 0.9532559765480131 6.162582665526626 0.9974736612092006 0.09539361948636743 0.09000059848499023 0.0649808818917072 0.08980561136984246 0.3250590244958443 1.160773388329486e-07 6.935252557009102 5.209326688978614 up LIYSGK(ub)QMNDEK(ub)TAADYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LIYSGKQMNDEKTAADYK 18 2 Q15843;S4R3E9 Q15843 NEDD8;NEDD8-MDP1 NEDD8 2 18057100.0 2217100.0 5700000.0 10140000.0 True False 3363502.7917213216 4682790.465696724 8135824.555480119 1.0 1.3922362357547615 2.418854705726732 21.68153302493683 -6.954471303552234 0.5073885980303284 0.9806927439863915 2.875237470171024 0.9995070612611509 0.013282099437577952 0.08173844075486557 0.028904799261960077 0.01536825396276493 0.08471547914584361 1.1105259120338252e-07 6.954471303552234 1.8945447261846327 up LIYSGK(ub)QMNDEK(ub)TAADYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LIYSGKQMNDEKTAADYK 18 2 Q15843;S4R3E9 Q15843 NEDD8;NEDD8-MDP1 NEDD8 2 8574680.0 734380.0 1772500.0 6067800.0 True False 1005900.1318732799 1694185.0891263303 4634710.610263695 1.0 1.6842478049697267 4.6075256016047135 19.94005564742667 -6.94336452319623 0.6274814881904124 0.9681063664960251 5.480537297810101 0.9985722215989831 0.05911484750219448 0.08626467609280986 0.047867581340127814 0.05913326649838631 0.24811415772943124 1.139293125371793e-07 6.94336452319623 4.512430931314076 LIYSGK(ub)QMNDEK(ub)TAADYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LIYSGKQMNDEKTAADYK 18 2 Q15843;S4R3E9 Q15843 NEDD8;NEDD8-MDP1 NEDD8 2 10341900.0 1743800.0 1874300.0 6723800.0 True False 1450046.9634383917 1864202.7738805767 8129715.492661372 1.0 1.2856154461784652 5.6065187525954086 20.467668195648844 -6.920320960828117 0.8223392921308258 0.905761119295334 6.308481787466849 0.9942696891191574 0.1595308471030624 0.09798332424008788 0.10463723363674408 0.13768623412670636 0.41371191588892176 1.2013762418138708e-07 6.920320960828117 5.402720668171515 up LIYSGK(ub)QMNDEK(ub)TAADYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LIYSGKQMNDEKTAADYK 18 2 Q15843;S4R3E9 Q15843 NEDD8;NEDD8-MDP1 NEDD8 2 26713300.0 2217100.0 7517000.0 16979200.0 True False 2870079.6555747115 7098672.342025948 13889159.821304165 1.0 2.4733363508701967 4.839294196705132 21.45265934702928 -6.9640992135193684 0.3731886944036464 0.8245077661901685 6.570892595369041 0.9998933564633276 0.01633130065808197 0.07826796802476567 0.015945901189170622 0.031042164846148534 0.20060146827804748 1.0861774606697714e-07 6.9640992135193684 5.746384829178872 LK(ub)AADALGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKAADALGK 9 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 3110800.0 403780.0 728320.0 1978700.0 True False 390962.22491799714 1019141.9741386245 1460419.1102724045 1.0 2.6067530548568616 3.7354481256564416 18.57666969435766 -8.039333752605108 0.20676065486868644 4.177910290661264e-15 5.125336595753345 0.9997969586948928 0.01599353953022049 0.10125633639528242 0.038763313753517686 0.34650581466709995 0.44274366836391676 9.134110209967074e-09 8.039333752605108 5.125336595753341 LK(ub)AADALGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKAADALGK 9 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 16946900.0 1166100.0 2686800.0 13094000.0 True False 1769058.9533292297 2207319.547935784 10505965.160695914 1.0 1.247736568519541 5.938730951235127 20.754550695508875 -6.917831074128695 0.8406676586702652 0.8881865648939351 6.658676172886106 0.9935567115418275 0.18237367798228202 0.0994645703028673 0.11235488197583167 0.15535516631853896 0.45612883826546924 1.2082837252359442e-07 6.917831074128695 5.770489607992171 up LK(ub)AADALGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKAADALGK 9 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 2343080.0 482190.0 529290.0 1331600.0 True False 660468.6736947859 505904.2176720305 1017103.5051628493 1.0 0.7659776122944745 1.5399723645831394 19.333130609902923 -6.825629065448868 1.347505350435061 0.8745313172475545 1.558974865601868 0.8968077145147225 0.10411449452191433 0.18627089603642866 0.6630245679255157 0.06069329929869876 0.1397120913797847 1.49406996242843e-07 6.825629065448868 0.6844435483543135 LK(ub)AADALGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKAADALGK 9 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 3047730.0 403780.0 916150.0 1727800.0 True False 335760.96048695594 911214.5181084624 2089074.9915554204 1.0 2.7138786974725204 6.221911530529409 18.357074969791935 -6.95958952438917 0.4411808064302591 0.8761007987281985 8.196731006867509 0.9997546710368536 0.03404153192933239 0.07984807765068169 0.02167558003312198 0.04632003768829988 0.2905982786123869 1.0975150279235678e-07 6.95958952438917 7.320630208139311 LK(ub)AADALGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKAADALGK 9 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 14755100.0 1166100.0 1931000.0 11658000.0 True False 1509539.437267454 1823538.152514577 9536363.621181427 1.0 1.2080096137239837 6.317399456912507 20.525677017601325 -6.915468248790943 0.8576513816295612 0.8678259709029476 7.061208188468685 0.9928269504660394 0.20826935333277688 0.10091235007387726 0.11996986390153863 0.17526468457369196 0.5042715388922665 1.2148754365984035e-07 6.915468248790943 6.193382217565738 up LK(ub)AALIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKAALIR 7 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 38135000.0 10448000.0 12538000.0 15149000.0 True False 13697429.178575933 10667379.272741212 13581526.79946902 1.0 0.7787869631350965 0.9915383844956691 23.70740180853939 -10.652403692510012 8.42908754842205 1.0001349470405243 0.8851626738298156 0.279783920515164 0.08685540406421074 0.00022052100300508134 9.093683811786184e-06 0.08419563572426304 0.028032461122400355 2.2263647002106394e-11 10.652403692510012 -0.11497227321070869 LK(ub)AALIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKAALIR 7 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 47562000.0 11094000.0 12982000.0 23486000.0 True False 10741827.042548576 18165780.30023565 17334312.035102673 1.0 1.6911257487465268 1.6137210147250687 23.356736061729343 -10.414568409876457 6.247629479276683 0.9998564610197762 1.6524233817357978 0.9895533629010045 0.03160035033807046 6.319351009431701e-05 5.921511878455464e-06 0.03060350755124008 0.010198969216138864 3.8497416893992104e-11 10.414568409876457 0.6525669207160216 LK(ub)AALIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKAALIR 7 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 104026000.0 22822000.0 27743000.0 53461000.0 True False 34622642.511688225 22792044.89295162 42894409.91721135 1.0 0.6582988252631865 1.2389120761862895 25.045212504254604 -6.747216958189823 1.6600566930260936 0.798405467972866 1.2398309589798262 0.6369285811578098 0.14357015079623134 0.3049331967367548 1.6524466453955096 0.06834396147958528 0.1664141200452024 1.7897115539692713e-07 6.747216958189823 0.44142549100696016 LK(ub)AALIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKAALIR 7 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 42176300.0 10448000.0 9197300.0 22531000.0 True False 14310907.94658355 8790932.874596097 17209641.84051078 1.0 0.6142819803892848 1.2025541569233031 23.770611870062282 -6.729812972761921 1.7238620627280676 0.7678288095694343 1.2021953497957407 0.5584178335793051 0.16214909396769853 0.33659038436409056 1.959480799191673 0.0745418914410204 0.18501334572496872 1.8628892099751998e-07 6.729812972761921 0.4343665402263064 LK(ub)AALIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKAALIR 7 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 55097000.0 11094000.0 24598000.0 19405000.0 True False 9225152.547531558 24465485.69167927 23462495.781417318 1.0 2.6520413148317723 2.5433179191920625 23.13714133716362 -10.27942718223633 5.149274229893044 0.999688783472229 2.5976796170122602 0.996538836416879 0.044386140404531954 0.00015861217646659766 2.2195509329236895e-05 0.042984470692792556 0.014325565215593087 5.255001178541236e-11 10.27942718223633 1.5979908335400312 LK(ub)AALIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKAALIR 7 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 93345000.0 22822000.0 26271000.0 44252000.0 True False 29543528.888875574 24808995.755934983 36198590.0638635 1.0 0.8397438183248532 1.2252629061348812 24.816338826347053 -6.793824450827502 1.4812035793285867 0.9108761680919566 1.229795326524778 0.8134235082935122 0.06830414950168215 0.22969748630580322 0.9954612651478904 0.036290981205911337 0.08472870762075646 1.607590937134802e-07 6.793824450827502 0.3189191584328215 LK(ub)AELGIPLEEVPPEEINYLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKAELGIPLEEVPPEEINYLTR 22 1 Q13907;Q13907-2 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 1 49825000.0 30872000.0 11082000.0 7871000.0 True False 29891985.25847844 15507100.391866552 5809348.975061448 1.0 0.5187711775506172 0.19434470226140996 24.833255380145246 -8.25697205371729 0.29148475595268225 1.157598948902157 3.802306110422927e-15 0.9990574754555793 0.010161189836510872 0.09704083679603319 0.0682071989927281 0.0881438299792376 0.09696837785466889 5.5338571771824305e-09 8.25697205371729 -1.1575989489021532 down LK(ub)AELGIPLEEVPPEEINYLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKAELGIPLEEVPPEEINYLTR 22 1 Q13907;Q13907-2 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 1 52876800.0 30872000.0 14458000.0 7546800.0 True False 25671435.861492198 14380111.884311693 9124800.987539316 1.0 0.5601600144961982 0.35544568043530234 24.613660655579523 -12.431651784391029 0.11967820078317959 2.4829502529491254 1.6317366673737051e-15 0.9997475366713114 0.004272746162523587 6.677889097122289 0.08998542091861506 2.7030868978256484 0.2797266234085017 3.701248254703061e-13 12.431651784391029 -2.4829502529491236 LK(ub)AELGIPLEEVPPEEINYLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKAELGIPLEEVPPEEINYLTR 22 1 Q13907;Q13907-2 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 1 92634000.0 30362000.0 20905000.0 41367000.0 True False 39304207.524495676 19741618.373028114 33838630.4612637 1.0 0.5022774816341097 0.8609416801031887 25.228180425799895 -9.855390762690865 5.665351648394484 1.000000104314856 0.6816095808675181 0.5123638929557142 0.1464240458795967 1.929243733413431e-07 3.9154426499303964e-08 0.14177451926928117 0.047258157597416424 1.3951125236531275e-10 9.855390762690865 -0.318390523447338 LK(ub)AMDQEITVNPQFVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKAMDQEITVNPQFVQK 17 1 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 48657900.0 21450000.0 17629000.0 9578900.0 True False 28121157.722095482 14998821.917303782 8587767.31529698 1.0 0.5333643111541898 0.3053845577826037 24.74515265426723 -10.37577807577527 0.1550414193193729 1.79959792038608 2.0333133432319112e-22 0.9996748555483886 0.0052129964597969905 2.1007369047631292 0.07856752535662867 0.844419164420029 0.19463748769002623 4.209416743835197e-11 10.37577807577527 -1.79959792038608 LK(ub)AMDQEITVNPQFVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKAMDQEITVNPQFVQK 17 1 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 66441000.0 27514000.0 19828000.0 19099000.0 True False 26640583.130402178 27745423.801654033 14096398.942281611 1.0 1.0414720903759427 0.529132522110405 24.667122325829872 -6.8872935564733435 1.038296859499306 1.0293412796544172 0.4873399621947506 0.9791073270252145 0.03358626279816927 0.12136498260377689 0.23491352479443242 0.02473107655723222 0.061081762631127995 1.2963027535061547e-07 6.8872935564733435 -0.5420013174596666 LK(ub)AMDQEITVNPQFVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKAMDQEITVNPQFVQK 17 1 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 57224000.0 21450000.0 24148000.0 11626000.0 True False 29380644.664454155 23081061.513242666 8880178.244985944 1.0 0.7855873067743483 0.30224586105591916 24.80836271579012 -6.957639268155493 0.4675250352291581 1.0130782820340738 0.055022875928305966 0.9996723491729029 0.005282345087835499 0.08055556319514132 0.024331499684406278 0.0066523199145963165 0.039900296339325604 1.1024546455543317e-07 6.957639268155493 -0.9580554061057678 down LK(ub)AMDQEITVNPQFVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKAMDQEITVNPQFVQK 17 1 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 64454900.0 27514000.0 28604000.0 8336900.0 True False 22879110.07686889 28449904.574550524 10080107.244529676 1.0 1.2434882510274639 0.4405812643351373 24.44752760126415 -6.8253578145200535 1.3485581615117386 1.1305765342391823 0.4209585581705241 0.8962599879588198 0.10826549107380286 0.18661052882002 0.6653356239400161 0.06306318987523665 0.14518353872898276 1.495003417650714e-07 6.8253578145200535 -0.7096179760686582 down LK(ub)AMDQEITVNPQFVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKAMDQEITVNPQFVQK 17 1 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 123193000.0 45218000.0 54305000.0 23670000.0 True False 58535592.38003574 51282879.01206847 19362302.874709617 1.0 0.8760973781408097 0.33077828526961933 25.802810781825926 -6.9426854964265186 0.6340877815144943 1.0059523945281859 0.1713269121306246 0.9984949169876105 0.011277999551395745 0.0865625783989916 0.04918890504741672 0.011216093212086296 0.0464077871687082 1.1410758227230815e-07 6.9426854964265186 -0.8346254823975613 down LK(ub)ASCQESAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKASCQESAR 10 1 A0A087X0G7;A0A087WUW6;A0A087X1B1;Q9Y6K9;Q9Y6K9-2;Q9Y6K9-3 A0A087X0G7 IKBKG NF-kappa-B essential modulator 1 3567450.0 1830700.0 829200.0 907550.0 True False 2400065.4285240173 705486.5921962848 813645.4318343201 1.0 0.29394473326093534 0.33900968788783914 21.19464230520817 -9.80874887438416 6.511312573159434 1.0000000119713897 0.31647721057425754 0.9967504768406754 0.01839769068673099 3.193283447572569e-09 6.11493424871512e-10 0.01781348767483094 0.0059378291364632916 1.5532849188499615e-10 9.80874887438416 -0.6835228013971322 LK(ub)ASCQESAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKASCQESAR 10 1 A0A087X0G7;A0A087WUW6;A0A087X1B1;Q9Y6K9;Q9Y6K9-2;Q9Y6K9-3 A0A087X0G7 IKBKG NF-kappa-B essential modulator 1 5582700.0 1906700.0 2322600.0 1353400.0 True False 1846172.8521748127 3250026.2921989947 998903.9388703044 1.0 1.7604127849515427 0.5410673966381773 20.816106204269392 -6.738070685866363 1.6938053542454312 1.453446838283051 0.5406520648732965 0.5962564974938817 0.31950984449377906 0.3213044912363811 1.809240449668423 0.14927638546531447 0.36708307197827317 1.8278026983580952e-07 6.738070685866363 -0.9127947734097545 LK(ub)ASCQESAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKASCQESAR 10 1 A0A087X0G7;A0A087WUW6;A0A087X1B1;Q9Y6K9;Q9Y6K9-2;Q9Y6K9-3 A0A087X0G7 IKBKG NF-kappa-B essential modulator 1 4676500.0 1906700.0 1367200.0 1402600.0 True False 1585505.5311320014 1359834.6222320476 1695877.1751103294 1.0 0.8576662745926645 1.0696129037780941 20.59651147970367 -6.725765594188566 1.7386113269957184 0.913942226968448 1.0693935127395402 0.5395288658561259 0.05985635814887204 0.3442469799849038 2.036541996682305 0.027304678365338904 0.06808345458264775 1.8803314317865867e-07 6.725765594188566 0.15545128577109224 LK(ub)AVQAQGGESQQEAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKAVQAQGGESQQEAQR 17 1 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4;Q14980-5;H0YFY6;K4DIE0 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 1 2875370.0 672890.0 1681700.0 520780.0 True False 559537.8490813507 1672640.3483086836 629672.6901853407 1.0 2.9893247633825393 1.1253442304557901 19.09387619783705 -6.63081892257001 2.0775416247119245 2.3098183662996346 1.1328744956227785 0.12043405485629355 0.8531386014205966 0.5568684010963683 4.581475283648385 0.3357468315207876 0.9450112418493283 2.3398126112621329e-07 6.63081892257001 -1.176943870676856 LK(ub)CDSAFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKCDSAFR 8 1 Q8N884;Q8N884-2 Q8N884 MB21D1 Cyclic GMP-AMP synthase 1 5412100.0 1712200.0 1607800.0 2092100.0 True False 2244710.780968387 1367922.5071553143 1875629.5608402656 1.0 0.6093981098826375 0.8355773833950685 21.09809814269059 -10.208458501195409 5.489072293825704 1.0000125445085934 0.7224877466388288 0.6674682289665929 0.09233730174989391 1.4175938468983237e-05 2.044149628832915e-06 0.08940924717984555 0.02980173599257661 6.18787452671838e-11 10.208458501195409 -0.2775247978697647 LK(ub)DAEKPVLFFER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKDAEKPVLFFER 13 2 D6RCP9;D6RFG8;P27707 D6RCP9 DCK Deoxycytidine kinase 1 11410200.0 3839700.0 4487800.0 3082700.0 True False 5033883.883707691 3818237.7333073826 2763731.7753464347 1.0 0.7585073119515565 0.549025730269888 22.263240507648423 -6.972788224221954 0.17949835406322773 1.1630209603392547 0.13885015066551798 0.9999967562110078 0.0003318188826955845 0.07540787684198093 0.005657585298780134 0.008102778987612413 0.023544386217935236 1.0646620546851454e-07 6.972788224221954 -1.0241708096737367 LK(ub)DAEKPVLFFER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKDAEKPVLFFER 13 2 D6RCP9;D6RFG8;P27707 D6RCP9 DCK Deoxycytidine kinase 1 14037400.0 4924600.0 5172300.0 3940500.0 True False 4768271.268589758 7237626.3631881755 2908364.837533935 1.0 1.5178721921432843 0.609941145062852 22.185034882875243 -6.752010427254156 1.6426211726342779 1.30377722859474 0.6078794456379866 0.6575071470929053 0.21763699085424204 0.2965426093728552 1.5748936208864697 0.10464273926395479 0.25348875215936106 1.7700664591488031e-07 6.752010427254156 -0.6958977829567534 LK(ub)DAEKPVLFFER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKDAEKPVLFFER 13 2 D6RCP9;D6RFG8;P27707 D6RCP9 DCK Deoxycytidine kinase 1 10136800.0 3839700.0 3500500.0 2796600.0 True False 5259340.853990888 3345836.335394476 2136100.677784937 1.0 0.636170278421029 0.4061536867617209 22.326450569171314 -8.638492257573654 0.15158519474570387 1.4381681760876972 2.6522787303134413e-17 0.9998813023335705 0.0026635629593161165 0.22289603418224677 0.04068353965034034 0.19424758438410855 0.15292757367905194 2.298834691593679e-09 8.638492257573654 -1.4381681760876972 LK(ub)DAEKPVLFFER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKDAEKPVLFFER 13 2 D6RCP9;D6RFG8;P27707 D6RCP9 DCK Deoxycytidine kinase 1 17397500.0 4924600.0 9137700.0 3335200.0 True False 4095023.0967706842 9088473.396408556 4032574.8997775344 1.0 2.2193949048970403 0.9847502210567759 21.96544015830952 -6.649017744945352 2.011801199313598 1.7918848111099808 0.9899185486932269 0.19010025343465375 0.5205783444424696 0.5109933089413118 3.962997904582718 0.20992683067278248 0.5766644661949406 2.2437902423308325e-07 6.649017744945352 -0.8019662624167538 LK(ub)DAVAHCHEAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKDAVAHCHEAER 13 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 2138850.0 787150.0 648850.0 702850.0 True False 762162.3541141258 907939.1887080508 518752.4999519671 1.0 1.1912674298422463 0.6806325412843591 19.53973882455205 -6.805250332900947 1.4343751349659029 1.1048385040857784 0.6726348283185939 0.8470731030334315 0.08237300464423043 0.21334724038521544 0.865957981430477 0.04516719258832677 0.10472502272417089 1.5658482349553843e-07 6.805250332900947 -0.43220367576718455 LK(ub)DAVAHCHEAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKDAVAHCHEAER 13 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 9521230.0 641130.0 1923400.0 6956700.0 True False 972641.0828813724 1580154.2424072102 5581705.195770077 1.0 1.6246015824523143 5.73871008947588 19.8915480045467 -6.9338937987573885 0.714105621996978 0.9455629004525145 6.6736597749375735 0.9972497366172743 0.11024306239346825 0.0906657931809245 0.06814055977893282 0.10287368805144344 0.36461464401270804 1.1644107365701329e-07 6.9338937987573885 5.728096874485059 up LK(ub)DAVAHCHEAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKDAVAHCHEAER 13 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 7314330.0 641130.0 1272100.0 5401100.0 True False 829955.4235616863 1201306.5167342296 4418155.219965952 1.0 1.4474349858199858 5.323364477824361 19.66267432663915 -6.928646514182966 0.7578201435444739 0.9380030892024562 6.092322627562846 0.9962654530416971 0.11862889006736005 0.0933468526357772 0.08116821632856086 0.10721880325294603 0.3533513503635877 1.1785648539104173e-07 6.928646514182966 5.15431953836039 up LK(ub)DDQTLDFYGIQPGSTVHVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKDDQTLDFYGIQPGSTVHVLR 22 1 Q96S82;H3BV23;H3BUV9 Q96S82 UBL7 Ubiquitin-like protein 7 1 42129300.0 6329300.0 17449000.0 18351000.0 True False 8297773.593028394 14845677.215669287 16452214.555221869 1.0 1.7891157247460088 1.982726374824767 22.984292862750742 -10.912011585594554 0.2724808390655249 4.035915172879669e-09 2.059101702696872 0.9992019083567381 0.012007630434694858 2.7697483507306995 0.14089345922373867 1.8415535052683882 0.0788727378249122 1.2245835308381688e-11 10.912011585594554 2.0591016986609567 LK(ub)DDQTLDFYGIQPGSTVHVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKDDQTLDFYGIQPGSTVHVLR 22 1 Q96S82;H3BV23;H3BUV9 Q96S82 UBL7 Ubiquitin-like protein 7 1 128984800.0 20141000.0 23401000.0 85442800.0 True False 19501634.979626015 32745141.334602896 63062767.45094402 1.0 1.6790972330685503 3.2337169430577344 24.217091746038626 -6.957320634480528 0.4716886966886176 0.9596048314514696 4.017121796582317 0.9996575267210056 0.017302570706746862 0.08067261992442892 0.024776670477765356 0.021563931252383855 0.1282963050750943 1.1032637925382641e-07 6.957320634480528 3.0575169651308474 LK(ub)DDQTLDFYGIQPGSTVHVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKDDQTLDFYGIQPGSTVHVLR 22 1 Q96S82;H3BV23;H3BUV9 Q96S82 UBL7 Ubiquitin-like protein 7 1 231675100.0 39137100.0 84943000.0 107595000.0 True False 59373842.00526655 69784257.98731181 86328801.08943628 1.0 1.1753367414074676 1.4539871124017676 25.823324135286892 -6.96427930581326 0.3702160759482633 0.9786240042654023 1.6604024911506363 0.9998975044476389 0.0018924958407699334 0.07820641889859799 0.015727711602452534 0.0036716178367797387 0.02366284670181542 1.0857271403313807e-07 6.96427930581326 0.681778486885234 LK(ub)DDQTLDFYGIQPGSTVHVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKDDQTLDFYGIQPGSTVHVLR 22 1 Q96S82;H3BV23;H3BUV9 Q96S82 UBL7 Ubiquitin-like protein 7 1 70356300.0 6329300.0 14926000.0 49101000.0 True False 8669413.252901156 14266519.966318538 37504355.06683768 1.0 1.6456154009666517 4.32605459824944 23.047502924273633 -6.944019749719593 0.6210409277938285 0.9706834511096699 5.143245479123779 0.9986444301734007 0.0530205864736951 0.08597969081824414 0.04661133956390803 0.05334516579831841 0.2269358345436755 1.1375755529325615e-07 6.944019749719593 4.172562028014109 LK(ub)DDQTLDFYGIQPGSTVHVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKDDQTLDFYGIQPGSTVHVLR 22 1 Q96S82;H3BV23;H3BUV9 Q96S82 UBL7 Ubiquitin-like protein 7 1 97346600.0 20141000.0 24707000.0 52498600.0 True False 16748133.897587277 24573898.487044506 63475814.53389935 1.0 1.4672618834618107 3.7900231107564544 23.997497021472903 -6.939934975259493 0.6601672012312626 0.9738987239193122 4.415203565318422 0.9981553833548136 0.052402048330730526 0.08779629251656958 0.05474464226268527 0.050984386682953 0.19997273046655348 1.14832554166581e-07 6.939934975259493 3.44130484139911 up LK(ub)DDQTLDFYGIQPGSTVHVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKDDQTLDFYGIQPGSTVHVLR 22 1 Q96S82;H3BV23;H3BUV9 Q96S82 UBL7 Ubiquitin-like protein 7 1 172538300.0 39137100.0 77415000.0 55986200.0 True False 50663747.45757656 73106787.19674584 45797286.066922955 1.0 1.442980254430686 0.9039458856704481 25.59445045737934 -6.688358138161668 1.87214331321905 1.2781540345765214 0.9058428215815791 0.36269033998617917 0.18741390792830986 0.4202692377187011 2.854582529185457 0.08012005291887322 0.20907921022692622 2.049471398319523e-07 6.688358138161668 -0.3723112129949423 LK(ub)DELASTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKDELASTK 9 1 P51572-2;P51572 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 7379800.0 3000400.0 2562000.0 1817400.0 True False 3933553.4559149286 2179759.5865977816 1629352.8817317972 1.0 0.5541451542548768 0.41421907697268506 21.90740175889217 -13.999999999999998 0.16222722152191943 3.20642453971248 0.2799900292241791 0.9995306875927523 0.005411110270601045 12.025277826962897 0.12735448190044513 8.347644612529532 0.12268893183989381 1.0000000000000041e-14 13.999999999999998 -2.926434510488301 LK(ub)DELASTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKDELASTK 9 1 P51572-2;P51572 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 5258700.0 2155200.0 1474200.0 1629300.0 True False 2086784.3556968379 2062855.7478514381 1202537.4520477203 1.0 0.9885332627781708 0.5762634019968768 20.992850092178934 -6.912854837729493 0.8760554861401838 1.0116413133923474 0.5195957506602611 0.9919553021921818 0.01767871711121074 0.10256072291431063 0.12874656610619412 0.014681268899004452 0.04137593131985814 1.2222081131028945e-07 6.912854837729493 -0.49204556273208633 LK(ub)DELASTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKDELASTK 9 1 P51572-2;P51572 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 5608300.0 3000400.0 1164800.0 1443100.0 True False 4109728.96276122 1113335.284521493 1102269.5015774318 1.0 0.2709023623235416 0.26820978014979496 21.970611820415062 LK(ub)DELASTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKDELASTK 9 1 P51572-2;P51572 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 5101930.0 2155200.0 2172000.0 774730.0 True False 1792144.2915485885 2160299.0048917527 936722.4610532051 1.0 1.2054269374845048 0.5226825013312879 20.77325536761321 -6.8260256474781285 1.3455126252654157 1.1101064793370634 0.5057509281950814 0.8976915947592 0.09147956790174307 0.1857750090455113 0.6591404569193742 0.053401347018290087 0.12293505202303755 1.492706254460578e-07 6.8260256474781285 -0.604355551141982 LK(ub)DLFGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKDLFGK 7 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAP2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 5471200.0 1530000.0 2390800.0 1550400.0 True False 2005844.8165410773 2034101.959265411 1389979.4804869485 1.0 1.0140874022214046 0.6929646147222194 20.935778564572974 -6.896641516027379 0.9822760602516821 1.0146090397861254 0.6614672143784986 0.9848194160776355 0.018255947331124196 0.11391910025389097 0.1916985623888889 0.014022696469179727 0.035906361262764794 1.2686986682024194e-07 6.896641516027379 -0.35314182540762673 LK(ub)DLFGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKDLFGK 7 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAP2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 5335300.0 1915300.0 1591700.0 1828300.0 True False 1854499.849882215 2227274.1106058457 1349413.3821756896 1.0 1.2010106718247007 0.7276427562188236 20.822598720382032 -6.791322275544233 1.4909631200113205 1.112151837991168 0.7224173965979933 0.8056054570454754 0.08552701898343328 0.233385448443324 1.024878267724582 0.04514768813358645 0.10560466334659437 1.6168797594622638e-07 6.791322275544233 -0.3897344413931746 LK(ub)DLFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKDLFGK 7 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAP2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 20202600.0 4249500.0 6427900.0 9525200.0 True False 6446802.180063942 5280791.023588078 7642540.044956536 1.0 0.8191334053832718 1.1854776727274627 22.62015228443514 -6.772511257861982 1.5653268760503827 0.8965903187266043 1.1877123807634002 0.7398927955053198 0.07627837484300329 0.2623934090853311 1.2692555287465122 0.038406061252023366 0.0911952260043595 1.688452090551705e-07 6.772511257861982 0.2911220620367959 LK(ub)DLFGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKDLFGK 7 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAP2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 5520600.0 1530000.0 2498300.0 1492300.0 True False 2095682.346695332 2387916.845226691 1139849.4748832393 1.0 1.1394459895089453 0.5439037441340576 20.998988626095866 -6.84502519626219 1.258988912693705 1.074203798406157 0.5223025635424935 0.9327279280031543 0.06596441218888344 0.16301690214971853 0.4997620634631849 0.04104777350216663 0.09472589500035293 1.4288110614355873e-07 6.84502519626219 -0.5519012348636635 LK(ub)DLFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKDLFGK 7 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAP2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 5984300.0 1915300.0 2885900.0 1183100.0 True False 1592656.8121765999 2870353.0838936996 1430480.739963662 1.0 1.8022420536229269 0.8981726188761907 20.60300399581631 -6.672603150435427 1.9285881484668503 1.5109269717428933 0.9018160981040592 0.2904849290605914 0.3405732779519357 0.4551378153639384 3.2662504943700754 0.14205654669787726 0.37819473595433156 2.1251855268123643e-07 6.672603150435427 -0.6091108736388341 LK(ub)DLFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKDLFGK 7 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAP2;H0YBN4 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 18302900.0 4249500.0 5672800.0 8380600.0 True False 5501061.520168123 5357103.693208026 6855416.792217628 1.0 0.9738309003758064 1.2461988958102241 22.39127860652759 -6.883326721927079 1.0610428853481813 0.9829398050055684 1.266778709887419 0.9762724506749343 0.018899383566827504 0.12472533081250552 0.2548097324985884 0.013677075356906454 0.033373572152648905 1.3081973892232616e-07 6.883326721927079 0.2838389048818506 LK(ub)DLGVLGSFIHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKDLGVLGSFIHR 13 1 H3BMM5;A0A2R8YF87;Q96AX1;F5H6Y0 H3BMM5 VPS33A Vacuolar protein sorting-associated protein 33A 1 7328400.0 1620300.0 2341600.0 3366500.0 True False 2124228.9910075213 1992242.4074853125 3018166.873748264 1.0 0.9378661226821843 1.4208293392685258 21.018507865778744 -6.874580502891241 1.1096491068893974 0.9636746560425251 1.451680680085599 0.96904143137791 0.03774680616619934 0.13253545064950942 0.30225928454052103 0.026320543933133413 0.06285714100830551 1.3348101398712174e-07 6.874580502891241 0.4880060240430739 LK(ub)DLGVLGSFIHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKDLGVLGSFIHR 13 1 H3BMM5;A0A2R8YF87;Q96AX1;F5H6Y0 H3BMM5 VPS33A Vacuolar protein sorting-associated protein 33A 1 15492500.0 2800100.0 2460400.0 10232000.0 True False 2711212.3581972476 3442850.5508165006 7551932.246579687 1.0 1.2698564686042288 2.7854447563824007 21.370506687339144 -6.937249183478613 0.6846734657335368 0.9819090959452184 3.1630726250536583 0.9977809883089237 0.037017226123170446 0.08904422771657834 0.06049366223569464 0.03532259445338345 0.13210200709097275 1.1554490943706643e-07 6.937249183478613 2.18116352910844 up LK(ub)DLGVLGSFIHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKDLGVLGSFIHR 13 1 H3BMM5;A0A2R8YF87;Q96AX1;F5H6Y0 H3BMM5 VPS33A Vacuolar protein sorting-associated protein 33A 1 35239000.0 4981000.0 12548000.0 17710000.0 True False 7556541.159877266 10308711.362028513 14209610.73743126 1.0 1.364210310500836 1.8804384753277852 22.84929459300847 -6.966181516068174 0.3371593649322853 0.9421327500707206 2.319598175975243 0.9999354696147069 0.0029016957319098107 0.07756227129375066 0.013458662729407152 0.007352344286181361 0.044776095141833346 1.0809820537242532e-07 6.966181516068174 1.3774654259045223 LK(ub)DLGVLGSFIHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKDLGVLGSFIHR 13 1 H3BMM5;A0A2R8YF87;Q96AX1;F5H6Y0 H3BMM5 VPS33A Vacuolar protein sorting-associated protein 33A 1 8603500.0 1620300.0 1691400.0 5291800.0 True False 2219368.6969610765 1616668.355288167 4041985.8280420233 1.0 0.7284361347899647 1.8212322421130878 21.081717927301636 -6.840920909577998 1.278074964912576 0.8555479062638891 1.857844529178348 0.9260360349591328 0.126344143461762 0.16772170056081712 0.5317839289927911 0.07750275721704236 0.1786014018756841 1.442378002566399e-07 6.840920909577998 1.002296622914459 LK(ub)DLGVLGSFIHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKDLGVLGSFIHR 13 1 H3BMM5;A0A2R8YF87;Q96AX1;F5H6Y0 H3BMM5 VPS33A Vacuolar protein sorting-associated protein 33A 1 14583300.0 2800100.0 2212900.0 9570300.0 True False 2328407.215462693 2200978.6684737396 11571405.481932424 1.0 0.9452722246595379 4.969665703270462 21.15091196277342 -6.903817897443236 0.9368120339031847 0.8497525323701687 5.426440944133769 0.9883719968909417 0.2031955562279836 0.10864942437920684 0.16199279323755264 0.16143297191691636 0.42866862091434316 1.2479066600954593e-07 6.903817897443236 4.5766884117636 up LK(ub)DLGVLGSFIHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKDLGVLGSFIHR 13 1 H3BMM5;A0A2R8YF87;Q96AX1;F5H6Y0 H3BMM5 VPS33A Vacuolar protein sorting-associated protein 33A 1 33749600.0 4981000.0 9638600.0 19130000.0 True False 6448002.690188816 9102203.436989656 15648536.290375771 1.0 1.411631457728675 2.426881166502357 22.62042091510092 -6.955750961605483 0.4916736275070394 0.9781153313513453 2.9035708343501994 0.9995787145894346 0.012307846005911588 0.08125536728675341 0.027016735360830494 0.014670451518534354 0.08373515137574335 1.10725853954948e-07 6.955750961605483 1.925455502998854 up LK(ub)DNKPNYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKDNKPNYK 9 2 B5MCF9;O00541-2;O00541 B5MCF9 PES1 Pescadillo homolog 1 3149540.0 746940.0 1184600.0 1218000.0 True False 979245.5733772488 1007862.2975346353 1091973.0438809996 1.0 1.0292232356575197 1.115116650581297 19.901311176008416 -6.951910441113366 0.5374670869525056 0.9987139246540829 1.1495753066346701 0.9993427554489485 0.001252536373685523 0.0827276743525437 0.03285761396289748 0.0013824903184800235 0.0071103793467872205 1.1170935876704273e-07 6.951910441113366 0.15086138198058718 LK(ub)DNKPNYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKDNKPNYK 9 2 B5MCF9;O00541-2;O00541 B5MCF9 PES1 Pescadillo homolog 1 3518430.0 634930.0 1526700.0 1356800.0 True False 614774.4946931105 2136319.2716353233 1001413.3768724902 1.0 3.474964056050753 1.6289117156240942 19.22969778724844 -6.571198234069508 2.3010186100732244 2.694158859735586 1.6327206705176467 0.0 1.0775719240372597 0.7262170190826251 7.219255624035683 0.3953652958819568 1.2079522814606274 2.6841189977017377e-07 6.571198234069508 -1.0614381892179394 LK(ub)DNKPNYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKDNKPNYK 9 2 B5MCF9;O00541-2;O00541 B5MCF9 PES1 Pescadillo homolog 1 2560970.0 634930.0 937320.0 988720.0 True False 527972.4271682182 932270.4711165465 1195456.7806752368 1.0 1.7657559810779935 2.264240932215103 19.010103062682717 -8.433161180274706 0.1399590815729272 2.3196600068430413e-21 3.2906555501153028 0.9999267383937952 0.0044504429201524896 0.12793968575760192 0.03357542022239753 0.3751792191226331 0.3420584136339396 3.68840684843182e-09 8.433161180274706 3.2906555501153028 LK(ub)DQDQDEDEEEKEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKDQDQDEDEEEKEK 15 2 P35269;M0R0R9;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 2588490.0 740930.0 795460.0 1052100.0 True False 717409.5827145771 1113091.3262690983 776523.4476765535 1.0 1.5515423170921652 1.0823990456585453 19.452437490491192 -10.1987807994617 3.7464303176948466 0.9996876189296214 1.3169706811640993 0.37835981859864454 0.1915269393046385 46804108.551787585 61004363.757122725 161999.81617887717 0.07544991475619825 6.327311278438472e-11 10.1987807994617 0.3172830622344779 LK(ub)DQDQDEDEEEKEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKDQDQDEDEEEKEK 15 2 P35269;M0R0R9;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 2204130.0 449920.0 846640.0 907570.0 True False 616267.5826308251 809232.6453359186 693220.6579908725 1.0 1.3131189569980823 1.1248695818649708 19.23319737781366 -10.246360908515596 3.9522749924593126 0.9997706254040656 1.2189942694574405 0.6434197732607901 0.07685248569846523 27350109.558326423 22379111.059757777 60995.806580071585 0.028125127902243155 5.670731589515907e-11 10.246360908515596 0.2192236440533749 LK(ub)DQDQDEDEEEKEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKDQDQDEDEEEKEK 15 2 P35269;M0R0R9;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 2155840.0 740930.0 877730.0 537180.0 True False 616116.1237644276 873001.4942742361 649501.854360308 1.0 1.4169431063421234 1.0541873995958682 19.23284276592547 -10.392161488423318 6.387313939952915 0.999969121525907 1.2355652529689958 0.3598992946958346 0.1480943971351692 6.512856482683536e-05 6.19765997965621e-06 0.1434105485098238 0.047797261147594784 4.053577788459351e-11 10.392161488423318 0.23559613144308877 LK(ub)DQDQDEDEEEKEKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKDQDQDEDEEEKEKR 16 3 P35269;M0R0R9;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 3295200.0 1205100.0 645400.0 1444700.0 True False 1166844.7601383887 903111.585716537 1066289.7299290136 1.0 0.7739774960376282 0.9138231291389189 20.15418120348325 -10.340752308577992 5.413340250154471 1.0000421374575836 0.84390031266337 0.6242421244609742 0.057091740642452156 2.9042036717263633e-05 3.5368442218968855e-06 0.05529374710564181 0.018426280059515555 4.562970819314927e-11 10.340752308577992 -0.15614182479421368 LK(ub)DQDQDEDEEEKEKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKDQDQDEDEEEKEKR 16 3 P35269;M0R0R9;M0QXD6 P35269 GTF2F1 General transcription factor IIF subunit 1 1 2896600.0 1205100.0 871530.0 819970.0 True False 1002094.0449819972 866834.8949048402 991421.9358870785 1.0 0.865023496792073 0.9893501920819114 19.934586478917527 -10.411134227121442 6.506427053609159 1.00001073489145 0.9271868444383202 0.313813601028855 0.05075616081109814 7.904886805858555e-06 7.153642019270928e-07 0.049151685888052306 0.016381480461567392 3.880304191388937e-11 10.411134227121442 -0.07282389045312976 LK(ub)DRDPEFYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKDRDPEFYK 10 2 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 2800770.0 812790.0 621680.0 1366300.0 True False 1065575.5610695556 528927.7672896599 1224928.3824750504 1.0 0.4963775321186576 1.1495462426386232 20.023201469075648 -6.700795313837939 1.8282095740784194 0.6875130764019245 1.1476217543421536 0.4212954234616231 0.21255447328494434 0.3938582454456838 2.5598870107745064 0.0927372642462806 0.23824632226510195 1.9916117790041693e-07 6.700795313837939 0.46010867794022914 LK(ub)DRDPEFYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKDRDPEFYK 10 2 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 11177500.0 1796100.0 3113000.0 6268400.0 True False 2724815.012498606 2557460.828019984 5029447.992462674 1.0 0.9385814509568629 1.8457942903987312 21.377726858072478 -6.890695498903376 1.0182886274282215 0.9520638442609722 1.92488600700089 0.9813386885755984 0.056547928828188966 0.11857950111582696 0.21858037402563404 0.042274734233720516 0.10565596837879888 1.286188141423932e-07 6.890695498903376 0.9728221627399177 LK(ub)DRDPEFYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKDRDPEFYK 10 2 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 3325740.0 812790.0 894450.0 1618500.0 True False 1113300.4278238541 854930.2414493911 1236243.6340538242 1.0 0.7679241111229123 1.1104312934382723 20.08641153059854 -6.724186207626419 1.7441972020702903 0.8594506741923317 1.110032162927104 0.5323527832300526 0.0976105335026051 0.3471792039192481 2.066289347689415 0.044397581332655596 0.11091185647651006 1.887182029507084e-07 6.724186207626419 0.25058148873477226 LK(ub)DRDPEFYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKDRDPEFYK 10 2 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 4704040.0 799840.0 2465600.0 1438600.0 True False 665102.398919925 2452317.3234167174 1739404.6086651362 1.0 3.6871274669871763 2.6152433241705264 19.343216948947067 -10.417710708485213 6.28255182823384 0.9995274854482232 3.1511853955788514 0.8430215761673867 0.43759486888022103 0.0028966772820827233 0.00026847556112689783 0.42377249867082917 0.1412331366299095 3.821987756754494e-11 10.417710708485213 2.151657910130628 LK(ub)DRDPEFYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKDRDPEFYK 10 2 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 12351000.0 1796100.0 2847800.0 7707100.0 True False 2325086.8564240374 2689317.42658261 6304486.881524056 1.0 1.156652457585501 2.711505965510596 21.148853180164927 -6.926317097147721 0.7764170080676901 0.9728502321488914 3.0027111333649574 0.995763797037331 0.05028162875858738 0.09459561328256552 0.08737971465562265 0.04484260917899648 0.1436414206108328 1.1849032832150812e-07 6.926317097147721 2.029860901216066 up LK(ub)DREDADIQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKDREDADIQR 11 2 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 11002700.0 2292800.0 3315300.0 5394600.0 True False 3005883.003506787 2820670.1629381827 4836418.540657185 1.0 0.9383832170605019 1.6089842934721077 21.519357426367744 -6.88443262049474 1.0547330918869873 0.9590138847816325 1.6607484009002964 0.977089944753583 0.045809061928941935 0.12377765651168615 0.24915469483475583 0.033310803510328425 0.08154489640836775 1.3048703997220184e-07 6.88443262049474 0.7017345161186639 LK(ub)DREDADIQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKDREDADIQR 11 2 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 25920900.0 5631000.0 4579900.0 15710000.0 True False 8542638.681242514 3762581.062077976 12604911.61406238 1.0 0.4404471735811158 1.4755290589240997 23.026250332887916 -6.759898080859056 1.6130070668355176 0.6749383492137356 1.479272746442776 0.6905027194306631 0.2353444413776399 0.28308332126638874 1.4516215193431286 0.11512452108829985 0.2766732940171348 1.738208699351183e-07 6.759898080859056 0.8043343972290403 LK(ub)DREDADIQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKDREDADIQR 11 2 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 12085400.0 2292800.0 2844600.0 6948000.0 True False 3140510.120590235 2718916.16616573 5307025.498551726 1.0 0.8657562185008116 1.689860976329002 21.582567487890636 -6.865114971392071 1.1595282472118797 0.9259052382927107 1.7338666999894863 0.9595651442963563 0.07259725118724536 0.1416301483536976 0.3589675163019902 0.04871785902025542 0.11446755628640823 1.3642219363789632e-07 6.865114971392071 0.8079614616967756 LK(ub)DREDADIQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKDREDADIQR 11 2 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 36931600.0 5631000.0 5592600.0 25708000.0 True False 7289440.503604355 5281366.893709495 21029407.786355495 1.0 0.7245229439897419 2.8849138388546063 22.797376654980365 -6.874882045712769 1.107890972668093 0.8384862617429162 3.023784597661079 0.9693199922154425 0.1681678046180356 0.1322627825875793 0.30047320841771774 0.11741286949438427 0.2806021692424219 1.3338836654845215e-07 6.874882045712769 2.1852983359181626 up LK(ub)DSAVLDQSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKDSAVLDQSAK 12 1 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 114040700.0 41354000.0 54411000.0 18275700.0 True False 54215494.472705655 46293090.89241679 16384705.876893267 1.0 0.8538719667257239 0.302214450615073 25.69220188856442 -6.946205676296425 0.5990624097030619 1.0062266504966124 0.12166606483501387 0.9988688007449087 0.010106071979989981 0.08504627770151679 0.04255194476580736 0.010381891590933424 0.046345692820209075 1.1318641999176043e-07 6.946205676296425 -0.8845605856615986 down LK(ub)DSAVLDQSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKDSAVLDQSAK 12 1 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 185473000.0 90222000.0 67856000.0 27395000.0 True False 87357951.99502593 94951254.6643652 20219427.667616345 1.0 1.0869217111428118 0.2314549185947905 26.380435698568505 -6.881859955248768 1.0693217197102198 1.0553274000480386 0.1686115578302684 0.9751570882152971 0.060591597346011467 0.12599752854809304 0.2624116106691898 0.04357206772322022 0.10588892452719946 1.3126231057336122e-07 6.881859955248768 -0.8867158422177702 down LK(ub)DSAVLDQSAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKDSAVLDQSAK 12 1 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 206182000.0 81481000.0 83571000.0 41130000.0 True False 123612634.05901633 68657102.10679667 33000637.47208063 1.0 0.5554213987060395 0.26696816003714596 26.881250963205186 -8.368224308667873 0.2309234663946616 1.2460222871269846 5.755773123960664e-13 0.9995624613618977 0.006306873779795554 0.11343435380697398 0.05514135978359973 0.1190774490363009 0.1124857009304943 4.283272366103739e-09 8.368224308667873 -1.246022287126409 down LK(ub)DSAVLDQSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKDSAVLDQSAK 12 1 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 125430400.0 41354000.0 64575000.0 19501400.0 True False 56643691.34982922 61721862.97903114 14895570.9639402 1.0 1.089651142222341 0.2629696372001206 25.75541195008731 -6.880042049758314 1.0796121346095475 1.0555885213279494 0.20434703909579038 0.9737172876732834 0.060046315160017745 0.12759064945183102 0.27208704896900693 0.04284392898107348 0.10361455637668651 1.3181291069698218e-07 6.880042049758314 -0.851241482232159 down LK(ub)DSAVLDQSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKDSAVLDQSAK 12 1 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 230179000.0 90222000.0 121327000.0 18630000.0 True False 75023590.51229425 120673387.3694762 22525446.86461248 1.0 1.6084725690341526 0.30024485246305554 26.16084097400278 -6.780238162899157 1.5350217522013114 1.3444244365231715 0.28981844331005857 0.768209845138987 0.25734002154949687 0.2502025680175686 1.1645043945733622 0.13204174671597385 0.31149081363955583 1.658677055506776e-07 6.780238162899157 -1.0546059932131129 LK(ub)DSAVLDQSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKDSAVLDQSAK 12 1 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 229758800.0 81481000.0 129631000.0 18646800.0 True False 105478760.73063153 122416920.89519274 15253273.732325096 1.0 1.1605836098872775 0.14460990655055614 26.652377285297636 -6.8664644276206985 1.152564966133274 1.0891494860437605 0.0889573640046779 0.961029135453656 0.08803121263954598 0.14029375430017169 0.3505287022666856 0.05939195597617461 0.13981920243004872 1.3599895533321055e-07 6.8664644276206985 -1.0001921220390826 down LK(ub)DSWVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKDSWVER 8 1 A0A0C4DFL7;Q16850-2;Q16850 A0A0C4DFL7 CYP51A1 Lanosterol 14-alpha demethylase 1 12309700.0 2553200.0 2506200.0 7250300.0 True False 3347269.925223968 2132284.729091087 6500108.505788519 1.0 0.6370220438521743 1.941913455143177 21.67455346456138 -6.83248386425711 1.316771731393344 0.8063594070970673 1.9788437866266202 0.9107547162668468 0.16428244351411816 0.17776387012395276 0.6019192709354674 0.09793175747860608 0.22536745650115256 1.4706730556600936e-07 6.83248386425711 1.172484379529553 LK(ub)DSWVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKDSWVER 8 1 A0A0C4DFL7;Q16850-2;Q16850 A0A0C4DFL7 CYP51A1 Lanosterol 14-alpha demethylase 1 25873000.0 2475800.0 4724200.0 18673000.0 True False 2397207.0841844035 6610597.696377549 13781981.122007677 1.0 2.757624795951518 5.749182543691961 21.19292311177858 -6.963072947910344 0.3897204724851869 0.8156961741300401 7.798551382806067 0.9998677334754704 0.02254759943118091 0.07862120604547089 0.017205176392542678 0.03863050800948791 0.2516741553272624 1.088747202444443e-07 6.963072947910344 6.9828552086760265 LK(ub)DSWVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKDSWVER 8 1 A0A0C4DFL7;Q16850-2;Q16850 A0A0C4DFL7 CYP51A1 Lanosterol 14-alpha demethylase 1 82823000.0 5466000.0 15867000.0 61490000.0 True False 8292321.618126719 13035409.880563173 49336474.54797561 1.0 1.5719855645816043 5.949657625450493 22.98334464185909 -6.930929717682536 0.7391207683281595 0.9356717525000827 6.870025409684178 0.9967178167694476 0.1266597341813984 0.09215804164750048 0.07533626768444776 0.11603763400228734 0.3940985998905347 1.1723850784659684e-07 6.930929717682536 5.934353657184095 up LK(ub)DSWVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKDSWVER 8 1 A0A0C4DFL7;Q16850-2;Q16850 A0A0C4DFL7 CYP51A1 Lanosterol 14-alpha demethylase 1 14286600.0 2553200.0 2759500.0 8973900.0 True False 3497187.0376356305 2637576.165553797 6854449.643271925 1.0 0.7541993428344064 1.9599894342242743 21.737763526084272 -6.853606301070325 1.217524959365375 0.8683077059159091 2.0116628280310103 0.9453967941202303 0.12156820043549844 0.15353245113743771 0.43614761018156845 0.07805212480227836 0.18108809966443945 1.4008566591272454e-07 6.853606301070325 1.1433551221151013 LK(ub)DSWVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKDSWVER 8 1 A0A0C4DFL7;Q16850-2;Q16850 A0A0C4DFL7 CYP51A1 Lanosterol 14-alpha demethylase 1 21769000.0 2475800.0 6579200.0 12714000.0 True False 2058737.396536744 6543756.543731047 15372438.617105907 1.0 3.1785290123641348 7.466925428646597 20.973328387212856 -6.960354363123738 0.430411121773429 0.8303992522378157 9.979619664739445 0.9997831155920401 0.039564657769666285 0.07957478134718203 0.020665432553506755 0.05594179443367485 0.35603569418166725 1.0955838882980005e-07 6.960354363123738 9.149220412501629 LK(ub)DSWVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKDSWVER 8 1 A0A0C4DFL7;Q16850-2;Q16850 A0A0C4DFL7 CYP51A1 Lanosterol 14-alpha demethylase 1 63996000.0 5466000.0 18210000.0 40320000.0 True False 7075844.750968101 17196597.492123507 32982173.718136493 1.0 2.4303243071819383 4.661234789474987 22.75447096395154 -6.964600218392913 0.36484837111399104 0.8181020914059353 6.35048741539685 0.9999046659926806 0.014709892373506506 0.07809688632095298 0.015339876623220092 0.029656031700954082 0.19000990018857516 1.084925161919064e-07 6.964600218392913 5.532385323990915 LK(ub)DWQEGGYTINDKPNPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKDWQEGGYTINDKPNPR 18 2 O60488-2;O60488;H0Y9A0 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 56148900.0 27251900.0 12920000.0 15977000.0 True False 41343124.68075874 10614325.055579258 12819138.947032139 1.0 0.2567373689710301 0.31006700741703297 25.30114409484903 -10.282010702546618 8.513695333507993 1.0000005527558486 0.2834021881940318 0.9958633633753102 0.021771733726636572 2.284277007223751e-07 1.925980275277126e-08 0.02108040686720242 0.00702679684511048 5.223833154745674e-11 10.282010702546618 -0.7165983645618168 LK(ub)DWQEGGYTINDKPNPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKDWQEGGYTINDKPNPR 18 2 O60488-2;O60488;H0Y9A0 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 52362900.0 27251900.0 13873000.0 11238000.0 True False 35278121.7652593 13100955.354652897 9192799.311617509 1.0 0.37136204250970845 0.2605807466958251 25.07227041694148 -13.999999999999998 0.24419459321473191 5.24717149550075 0.21351108229548213 0.9995321243408398 0.0070430911029989085 13.775248327810894 0.15638438704423904 28.600008481979916 0.05282924210424855 1.0000000000000041e-14 13.999999999999998 -5.033660413205268 LK(ub)DYAFIHFDER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKDYAFIHFDER 12 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 7496700.0 1118900.0 1439600.0 4938200.0 True False 1466888.7354430151 1224817.2915168477 4427242.434559238 1.0 0.8349762745617789 3.0181174124444867 20.484328015037423 -6.888677630171031 1.0302152706422427 0.8789508468666898 3.2010655400928343 0.9800367854102097 0.14023653598428898 0.12022092807787783 0.22818820600564496 0.1038980331723693 0.25780658225586367 1.2921780807821243e-07 6.888677630171031 2.3221146932261445 up LK(ub)ECEDTHLGEEVDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKECEDTHLGEEVDR 15 1 O43847-2;G3V1R5;O43847;H0Y5G9 O43847-2 NRD1 Nardilysin 1 4334400.0 1067800.0 1988200.0 1278400.0 True False 1399896.14058991 1691568.3099428993 1146123.4312787126 1.0 1.2083527205311673 0.8187203307780684 20.41688836577011 -6.761449868640037 1.607077360609504 1.1208045895756555 0.817196985156499 0.6968399269203758 0.08765256043908251 0.2804854219407808 1.4280688634399044 0.043027693023863084 0.10325214841098258 1.732008947987129e-07 6.761449868640037 -0.3036076044191566 LK(ub)ECEDTHLGEEVDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKECEDTHLGEEVDR 15 1 O43847-2;G3V1R5;O43847;H0Y5G9 O43847-2 NRD1 Nardilysin 1 4172900.0 1067800.0 1033400.0 2071700.0 True False 1462594.5162099842 987740.9710031875 1582407.1280008068 1.0 0.6753347972086734 1.0819178592993037 20.480098427293 -6.694030968186768 1.8522122973429305 0.7972301216203401 1.080581035466639 0.3893382045746342 0.1372000032697756 0.40804139156162866 2.717141088981881 0.05919170499081278 0.153353945684964 2.022874928624995e-07 6.694030968186768 0.28335091384629885 LK(ub)EDKAPQVDVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKEDKAPQVDVDK 13 2 P41250 P41250 GARS Glycine--tRNA ligase 1 4698900.0 1557400.0 1924800.0 1216700.0 True False 2041766.4818830553 1637627.3428116376 1090807.5554105204 1.0 0.8020639761415355 0.5342469695185239 20.961386443035476 -6.966913972757129 0.32352453841049345 1.0351931119904778 0.2924344979548215 0.9999473352425321 0.0013850316481936926 0.0773173388678955 0.012601050700301016 0.0040032185031333095 0.0234856274880806 1.0791604666111244e-07 6.966913972757129 -0.7427586140356564 LK(ub)EDKAPQVDVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKEDKAPQVDVDK 13 2 P41250 P41250 GARS Glycine--tRNA ligase 1 17080000.0 7610000.0 4811900.0 4658100.0 True False 11544926.36552219 3953178.8494536984 3737424.493282246 1.0 0.34241698251618874 0.32372874238883875 23.46075563572679 LK(ub)EDKAPQVDVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKEDKAPQVDVDK 13 2 P41250 P41250 GARS Glycine--tRNA ligase 1 4309800.0 1557400.0 1519600.0 1232800.0 True False 2133212.867152491 1452459.0473547915 941638.0303129768 1.0 0.6808786266574509 0.44141775291741875 21.024596504558367 -7.619526564008609 0.16751884032985576 1.2712501013803577 4.4600819137759713e-13 0.9999663481471661 0.001327330407943218 0.1345545564582388 0.018293262523489052 0.046905361803217895 0.07808452950701521 2.4014493766044035e-08 7.619526564008609 -1.2712501013799116 down LK(ub)EDKAPQVDVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKEDKAPQVDVDK 13 2 P41250 P41250 GARS Glycine--tRNA ligase 1 19354000.0 7610000.0 6918600.0 4825400.0 True False 9851295.015526384 6533573.82806181 3947226.7127851187 1.0 0.663219791688748 0.4006809974286621 23.23188195781924 -7.597795171094928 0.19224517023197926 1.2215066633159868 1.2818115658585345e-10 0.99994333917499 0.0018464163962740264 0.13294771098204444 0.020762906376894957 0.04080512500715519 0.07470874674316613 2.5246712175226697e-08 7.597795171094928 -1.2215066631878055 down LK(ub)EEEDEYETSGEGQDIWDMLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKEEEDEYETSGEGQDIWDMLDK 23 1 G3V2F4;E7EPD8;Q9NUW8;G3V4W8;G3V2J6;G3V5H9;G3V2U6;Q9BRS7;G3V554 G3V2F4 TDP1 Tyrosyl-DNA phosphodiesterase 1 1 9273600.0 2941900.0 4108300.0 2223400.0 True False 2446320.1982678133 4086167.7724662945 2688302.660159923 1.0 1.670332352796507 1.0989169210406113 21.22218181955889 -10.257139402321918 3.99813523755638 0.9995928597681693 1.3846246369515796 0.3765975597237329 0.23327937332501866 77738853.1477389 207.85969546569896 294907.502073099 0.08417744309032346 5.531725202422349e-11 10.257139402321918 0.3850317771834103 LK(ub)EENFFNPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKEENFFNPK 10 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 9729700.0 2680600.0 3203400.0 3845700.0 True False 2595505.820286256 4482534.32551031 2838395.8014729787 1.0 1.7270368998887222 1.093580981128347 21.30758429222583 -10.2323122680621 4.488913728609345 0.9998530982460809 1.4103089405132383 0.3587305961979622 0.25860729593411724 0.00038033418904105844 6.504370196526686e-05 0.2504844926111904 0.08346514586113797 5.857168687115593e-11 10.2323122680621 0.41045584226715737 LK(ub)EENFFNPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKEENFFNPK 10 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 5704000.0 2480100.0 1049400.0 2174500.0 True False 3397059.9921824164 1003034.0380982615 1660927.8852332635 1.0 0.2952653295515896 0.48893098416145797 21.695855265804408 -10.387632950801377 5.130776207144214 1.0004384450528157 0.3920981568567299 0.9292642759366089 0.07906367241618326 0.0003968061049889082 4.735938943932356e-05 0.07660620355990101 0.025517690546469653 4.09606697501481e-11 10.387632950801377 -0.6083402881960858 LK(ub)EENFFNPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKEENFFNPK 10 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 7701500.0 2680600.0 3218000.0 1802900.0 True False 2229037.6707150806 3200663.995277011 2179878.054332253 1.0 1.4358949771585647 0.9779458117605266 21.087989567660106 -8.924004345763953 18.643458129388943 0.9999959271362157 1.2069203944595461 0.21396884696657548 0.18695696390788982 0.0 0.0 0.1810203019115077 0.06034010063716922 1.1912300879342306e-09 8.924004345763953 0.20692446732333047 LK(ub)EENFFNPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKEENFFNPK 10 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 25636400.0 13726300.0 5329200.0 6580900.0 True False 17768965.935823917 5032625.335256705 5383243.725736231 1.0 0.28322556041994856 0.30295762540031107 24.082856390447756 -10.458765081027217 9.389596434244815 1.0000058530964835 0.29309159298462517 0.9994159815638047 0.008055581795554852 9.870413005628664e-07 5.6903296676141104e-08 0.00779984803097646 0.002599927844849635 3.477242018779705e-11 10.458765081027217 -0.7069142601118583 LK(ub)EEQATCPNCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKEEQATCPNCR 12 1 E9PJD7;Q6ZMK1-2;Q6ZMK1;E9PQ42;Q6ZMK1-4 E9PJD7 CYHR1 Cysteine and histidine-rich protein 1 1 5947400.0 1289000.0 1082600.0 3575800.0 True False 1955507.2385227485 889401.5716075931 2869041.562671187 1.0 0.45481885931523064 1.4671597763240962 20.899111445697535 -6.760432067437563 1.6106789030661892 0.683488058684813 1.470953822759079 0.6927249546541072 0.22932126283361615 0.2822276384294084 1.4431250920142926 0.11232524995409432 0.2698380055347777 1.736072799018961e-07 6.760432067437563 0.787465764074266 LK(ub)EEQATCPNCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKEEQATCPNCR 12 1 E9PJD7;Q6ZMK1-2;Q6ZMK1;E9PQ42;Q6ZMK1-4 E9PJD7 CYHR1 Cysteine and histidine-rich protein 1 1 4589400.0 1289000.0 1453800.0 1846600.0 True False 1668635.909988636 1372894.7520070919 1510537.7477160434 1.0 0.8227647168497302 0.9052530505149747 20.670237767789985 -10.207718084843666 4.746972629578973 1.000023581420971 0.8640088836818172 0.7837317754949418 0.033675721203887586 8.405824168174672e-06 1.402944416232928e-06 0.03261202865306644 0.010868792282587565 6.198433056509943e-11 10.207718084843666 -0.13601469773915387 LK(ub)EEYQSLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKEEYQSLIR 10 1 Q9Y3C8 Q9Y3C8 UFC1 Ubiquitin-fold modifier-conjugating enzyme 1 1 9400600.0 3448200.0 3178600.0 2773800.0 True False 3338738.7784492495 4447831.556180027 2047258.5677836905 1.0 1.3321891442630083 0.6131832118757685 21.670871791273193 -6.781081871947813 1.5316745442565576 1.1878301932252788 0.6072953842282672 0.771188372466859 0.14054432548868367 0.2488999815870289 1.1534355793648383 0.07226614423823363 0.17036283639002475 1.6554578518938694e-07 6.781081871947813 -0.5805348089970116 LK(ub)EEYQSLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKEEYQSLIR 10 1 Q9Y3C8 Q9Y3C8 UFC1 Ubiquitin-fold modifier-conjugating enzyme 1 1 7667700.0 2529700.0 2261100.0 2876900.0 True False 3464998.452572009 2161197.125542195 2197435.471615348 1.0 0.6237223927006303 0.6341807945063379 21.72442327739599 -9.952680581782177 4.961417939679151 1.0000020146111066 0.628951593595754 0.9994045121900322 0.00426962469393581 5857355.032621475 0.9856289637849458 158.0386327786602 0.001461606092633179 1.1151143848920722e-10 9.952680581782177 -0.37105042101535257 LK(ub)EEYQSLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKEEYQSLIR 10 1 Q9Y3C8 Q9Y3C8 UFC1 Ubiquitin-fold modifier-conjugating enzyme 1 1 13208000.0 5151600.0 3648500.0 4407900.0 True False 6668847.753217581 3445457.7677107374 3605707.4288733583 1.0 0.5166496365205482 0.5406792241033962 22.669006082709952 -10.3747023258172 5.8375726148125135 1.0001054653107038 0.5286644303119749 0.9980544256047035 0.009810038051252001 1.346823340272001e-05 1.4426625317512677e-06 0.009500634675160142 0.0031661761665129585 4.219856417825694e-11 10.3747023258172 -0.4714410349987289 LK(ub)EHEDYCGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKEHEDYCGAR 11 1 O14545;F8VNX8;F8VVF3;O14545-2 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 22356400.0 12002000.0 7214600.0 3139800.0 True False 11621003.079562636 10095427.403641988 2317392.1880190503 1.0 0.8687225478320703 0.1994141273479696 23.47023126612551 -6.939371380681755 0.6653869059490057 1.0076003094649106 0.02221299918894336 0.99808038529096 0.015360021818873738 0.08805461980237289 0.05592464119202431 0.014881540335632465 0.057767437432692165 1.1498167191839271e-07 6.939371380681755 -0.9853873102759673 down LK(ub)EHEDYCGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKEHEDYCGAR 11 1 O14545;F8VNX8;F8VVF3;O14545-2 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 36510000.0 13872000.0 10556000.0 12082000.0 True False 21044838.179043863 8672199.32559555 9693987.40427127 1.0 0.4120820151628059 0.4606349225305233 24.326963080557718 -10.127994532658041 8.017488812801158 1.0000000575054997 0.4363584706016476 0.9944655362562353 0.019821641429920975 2.0387275711766604e-08 2.2115602867029636e-09 0.019192223790027725 0.006397407262714937 7.44741349410786e-11 10.127994532658041 -0.563641586903852 LK(ub)EHEDYCGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKEHEDYCGAR 11 1 O14545;F8VNX8;F8VVF3;O14545-2 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 30606000.0 11808000.0 12721000.0 6077000.0 True False 16173736.699201614 12158944.15727844 4641737.759743646 1.0 0.7517708729534743 0.28699229164357404 23.947149694576247 -6.961326614569783 0.416509578100576 1.0213327023295744 3.7322035612234356e-06 0.9998158618146155 0.004010201037042392 0.07923309266615752 0.019421745562992927 0.0060001913646260735 0.038726737747256705 1.0931339570991222e-07 6.961326614569783 -1.021328970126013 down LK(ub)EHEDYCGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKEHEDYCGAR 11 1 O14545;F8VNX8;F8VVF3;O14545-2 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 23928700.0 12002000.0 7303700.0 4623000.0 True False 9980194.778751906 7264353.51842905 5589647.925663099 1.0 0.72787692820335 0.5600740315773801 23.250636541559786 -9.723794908952392 0.08931900998613494 1.7689238494184176 9.883668920971278e-10 0.9999609680081502 0.00113250769937126 1.2398410993839935 0.038254796634321846 0.48908210437439437 0.27076122329566826 1.888883143908725e-10 9.723794908952392 -1.7689238484300507 LK(ub)EHEDYCGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKEHEDYCGAR 11 1 O14545;F8VNX8;F8VVF3;O14545-2 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 40178000.0 13872000.0 14936000.0 11370000.0 True False 17957577.45800026 14104798.470200786 9300776.66605189 1.0 0.7854510722946637 0.5179304774157224 24.098089402650167 -6.968146063013787 0.2991716330376788 1.0468561399460439 0.24815270931799316 0.9999640954771626 0.0011816141166994137 0.076908947603156 0.011171802170411428 0.004456585826406375 0.02401386506477713 1.0761032350126417e-07 6.968146063013787 -0.7987034306280507 LK(ub)EHGLSIQGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKEHGLSIQGNK 12 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 5286800.0 1101500.0 1478300.0 2707000.0 True False 1066533.4854306162 2068592.899232658 1997955.4917407383 1.0 1.9395480099693798 1.8733171710347731 20.024497831304874 -10.130280355992646 4.596704500689018 0.999909191242004 1.9064325905197927 0.996011815293563 0.027038626831251373 18877647.99706471 3.272033466455545 18201.278476281626 0.009256041140639966 7.408318476999292e-11 10.130280355992646 0.9065233992777888 LK(ub)EHGLSIQGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKEHGLSIQGNK 12 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 4629070.0 1101500.0 2641600.0 885970.0 True False 915946.0547238156 2627369.1764834514 1071222.2307375588 1.0 2.868475892148124 1.1695254597286993 19.80490310673915 -6.623490770667837 2.103599846354081 2.2367744307625363 1.1761110458750754 0.09457799292644131 0.8028056119069873 0.5762824992650583 4.850430655452934 0.3130293056678527 0.8900397009411043 2.3796288706799902e-07 6.623490770667837 -1.060663384887461 LK(ub)EIYENMAPGENKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKEIYENMAPGENKR 15 2 Q13200;C9JPC0;H7C2Q3 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 6405900.0 1362400.0 1264200.0 3779300.0 True False 1319151.357740057 1769001.6527159093 2789387.9534302773 1.0 1.3410149201881782 2.11453214755356 20.331178676395172 -6.957511017347036 0.4692027714131834 0.979410189949322 2.5078044858380317 0.9996664395937414 0.008516072158648998 0.08060258932312417 0.02451002073258832 0.010679182913097395 0.06384629149956943 1.1027802577471124e-07 6.957511017347036 1.5283942958887096 up LK(ub)EIYENMAPGENKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKEIYENMAPGENKR 15 2 Q13200;C9JPC0;H7C2Q3 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 5355400.0 1362400.0 1650500.0 2342500.0 True False 1132895.964553543 1641608.4289014027 2832305.919503741 1.0 1.4490372287170568 2.500058264943957 20.11158395182945 -6.956857807011556 0.47766726843666774 0.9742103004356142 3.018532317121291 0.999635307813862 0.01200467894073618 0.08084333929227408 0.025428633942214045 0.014749686411743504 0.08670823740731112 1.1044401670741373e-07 6.956857807011556 2.044322016685677 up LK(ub)EIYENMAPGENKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKEIYENMAPGENKR 15 2 Q13200;C9JPC0;H7C2Q3 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 16418700.0 2598500.0 4766300.0 9053900.0 True False 3363809.47409268 4501051.215085566 7406183.1008590385 1.0 1.3380814965150885 2.20172490680576 21.681664563096234 -6.954997671022442 0.5009866315441609 0.9828508381056599 2.5942675865126654 0.9995373428053784 0.010883783834647696 0.08153889902698833 0.028121648078213952 0.012740311338725442 0.07124521315132325 1.1091807634157559e-07 6.954997671022442 1.6114167484070054 up LK(ub)EK(ub)KPGDLSDELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKEKKPGDLSDELR 14 3 Q13435;E9PPJ0;H0YEX5 Q13435 SF3B2 Splicing factor 3B subunit 2 2 2145420.0 819220.0 1326200.0 0.0 True False 793214.309518356 1855758.5760416351 0.0 1.0 2.3395424840084664 0.0 19.597351178333575 -6.753743476686797 1.6511214280027144 1.7862275642557754 7.139353379617567e-10 0.6549385023968111 0.5630187357794785 0.29575900712459974 1.5900886085190655 0.2699585491088326 0.648965952625589 1.7630170945148385e-07 6.753743476686797 -1.78622756354184 LK(ub)ELQNEVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKELQNEVEK 10 1 Q92843-2;Q86U42-2;Q86U42;B4DEH8;G3V4T2 Q92843-2 PABPN1 Polyadenylate-binding protein 2 1 10379400.0 3342400.0 3600000.0 3437000.0 True False 4381918.767847638 3062894.0326900925 3081372.2100320207 1.0 0.6989846674393192 0.7032015820652845 22.063131309172704 -9.900924604976035 5.220283744021457 1.0000005470795346 0.7010931247482299 0.9998507483505711 0.0017215482016401764 2349452.77156896 0.38624800710052015 15.448771111403387 0.0005893317376956562 1.256248033768571e-10 9.900924604976035 -0.29890742233130463 LK(ub)ELQNEVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKELQNEVEK 10 1 Q92843-2;Q86U42-2;Q86U42;B4DEH8;G3V4T2 Q92843-2 PABPN1 Polyadenylate-binding protein 2 1 17135500.0 5907300.0 4699200.0 6529000.0 True False 5719775.994992531 6575615.0660042595 4818859.034198474 1.0 1.149628074903805 0.8424908664984819 22.447527216810087 -6.774237298460195 1.55826429902466 1.085357401042021 0.8404809142830859 0.7464917263451658 0.06313941124346428 0.25963263078454973 1.2447282473689385 0.03192758218355084 0.07570843617990079 1.6817548992745791e-07 6.774237298460195 -0.24487648675893514 LK(ub)ELQNEVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKELQNEVEK 10 1 Q92843-2;Q86U42-2;Q86U42;B4DEH8;G3V4T2 Q92843-2 PABPN1 Polyadenylate-binding protein 2 1 19984100.0 3237000.0 7627500.0 9119600.0 True False 4910765.656398866 6266313.0310704885 7317107.062737331 1.0 1.2760358505206424 1.490013487652976 22.227516547545058 -6.973970549171223 0.1325670303158819 0.6808274011002786 2.0907708192269587 0.9999991509348316 0.00018473483228688054 0.0750340614673598 0.003988493633234585 0.013090725181408372 0.028861865397978814 1.0617675564425058e-07 6.973970549171223 1.4099434181266801 LK(ub)ELQNEVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKELQNEVEK 10 1 Q92843-2;Q86U42-2;Q86U42;B4DEH8;G3V4T2 Q92843-2 PABPN1 Polyadenylate-binding protein 2 1 10864100.0 3342400.0 3584500.0 3937200.0 True False 4578175.604963704 3426124.9376436234 3007314.449179309 1.0 0.7483603149536213 0.6568805368493835 22.126341370695595 -13.999999999999998 0.14075308976008308 2.2028634508054665 0.5446901277177976 0.9995999471431745 0.0029016955028648064 11.934856760486047 0.1175990956988351 3.941334263062455 0.10034852147809138 1.0000000000000041e-14 13.999999999999998 -1.658173323087669 LK(ub)ELQNEVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKELQNEVEK 10 1 Q92843-2;Q86U42-2;Q86U42;B4DEH8;G3V4T2 Q92843-2 PABPN1 Polyadenylate-binding protein 2 1 19624400.0 5907300.0 9952200.0 3764900.0 True False 4912181.687762135 9898585.523242963 4552123.183069214 1.0 2.0151098132024727 0.9267008983829028 22.227932492244364 -6.6618682243745875 1.9665165603698351 1.6524131008918408 0.9312449847784025 0.24350243223060242 0.43201961726320287 0.4800083627918313 3.5704533424663936 0.17738015175367203 0.4789429413580344 2.1783706433066662e-07 6.6618682243745875 -0.7211681161134383 LK(ub)ELQNEVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKELQNEVEK 10 1 Q92843-2;Q86U42-2;Q86U42;B4DEH8;G3V4T2 Q92843-2 PABPN1 Polyadenylate-binding protein 2 1 26303900.0 3237000.0 14501700.0 8565200.0 True False 4190360.3108093217 13694667.64698117 7006421.4863735875 1.0 3.2681360625850804 1.672033182516559 21.998642869637507 -6.554613353418734 2.368649855510001 2.5673468753399686 1.6741717623367591 0.0 0.9916394511572091 0.7789016918309779 8.183897365435772 0.35750788142059975 1.1176878190177653 2.7886027196053576e-07 6.554613353418734 -0.8931751130032095 LK(ub)EQLLDCEGEDGWNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKEQLLDCEGEDGWNK 16 1 J3KNE0;A6NKT7;Q7Z3J3;C9J6W1;Q7Z3J3-2;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD5;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;E3 SUMO-protein ligase RanBP2 1 22227300.0 5733200.0 4305100.0 12189000.0 True False 7421740.418267535 4065517.4005129565 9970727.06970153 1.0 0.5477849091173111 1.3434486397772731 22.823326111746404 -6.752534693181478 1.6405250549919292 0.7349064524973506 1.345335683446763 0.6597954185058919 0.19005198196774478 0.2956373895121061 1.5662065238845964 0.09148737554394024 0.2215134694933384 1.7679309826901427e-07 6.752534693181478 0.6104292309494123 LK(ub)ETAENSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKETAENSLK 10 1 Q92598-2;Q92598;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 6235500.0 1378900.0 2332600.0 2524000.0 True False 1807751.2532865966 1984585.1724035863 2262840.691917608 1.0 1.0978198293573274 1.2517433954498067 20.785764745783744 -6.964449548992364 0.36737672270473193 0.9878054845613686 1.367093584397754 0.9999013422557029 0.0010292166358205985 0.07814824798606979 0.015521583669575734 0.0020372858617713242 0.013091330720797453 1.0853016193443085e-07 6.964449548992364 0.37928809983638545 LK(ub)ETAENSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKETAENSLK 10 1 Q92598-2;Q92598;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 5265100.0 1735400.0 1851900.0 1677800.0 True False 1680310.676909933 2591373.327530919 1238333.8470789078 1.0 1.5421989297219827 0.7369671954689866 20.680296570542016 -6.725297461113069 1.7402965948749616 1.3279846747257062 0.737833625607621 0.5373976059550352 0.2280233822489379 0.34511070628072205 2.0453781230186157 0.10392649876005755 0.2592787256904704 1.8823593643500727e-07 6.725297461113069 -0.5901510491180852 LK(ub)ETAENSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKETAENSLK 10 1 Q92598-2;Q92598;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 29513500.0 3949000.0 7999200.0 17565300.0 True False 5990921.710571245 6571680.2619651295 14093510.75585552 1.0 1.0969397664417997 2.3524778718084227 22.514346549796233 -6.922322308446733 0.8073167242560046 0.9745475217445623 2.566169331613496 0.9948020857469432 0.044410608215528675 0.09682445404951985 0.09867458968949407 0.03874262604812708 0.11875908444742894 1.195852708634415e-07 6.922322308446733 1.5916218098689339 up LK(ub)ETAENSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKETAENSLK 10 1 Q92598-2;Q92598;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 5076200.0 1378900.0 1531600.0 2165700.0 True False 1888716.5933713692 1463928.8476761 1654206.2639915743 1.0 0.7750918548679552 0.8758361470414189 20.848974807306636 -10.150302731851129 4.7187315106310646 1.0000170762170828 0.8254640009532056 0.8000765708985985 0.041128685058891834 7.389369707647233e-06 1.3305596707485313e-06 0.03982657268748473 0.013274226022987883 7.074524715116555e-11 10.150302731851129 -0.1745530752638772 LK(ub)ETAENSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKETAENSLK 10 1 Q92598-2;Q92598;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 5721200.0 1735400.0 2474200.0 1511600.0 True False 1443061.991255297 2460870.99350975 1827668.5711512754 1.0 1.7053120437113563 1.2665211766553528 20.460701845976292 -10.401584306091364 4.932412677774548 0.9994568390653538 1.485916610183434 0.6205092506667016 0.17913562134705296 0.001071124778152724 0.00012995213854963028 0.17363450733843683 0.057815773182430724 3.966575215262304e-11 10.401584306091364 0.48645977111808025 LK(ub)ETAENSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKETAENSLK 10 1 Q92598-2;Q92598;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 30638700.0 3949000.0 8090100.0 18599600.0 True False 5112058.34642756 7639878.823230542 15214663.6480122 1.0 1.494481929880454 2.976230437323667 22.285472871888683 -6.9514768922850925 0.5423933591033536 0.9785216729539182 3.56089839406206 0.9993121090714736 0.022022879712188505 0.08289817779286704 0.03355034837667748 0.024143823459654504 0.12275746871817839 1.118209320101302e-07 6.9514768922850925 2.582376721108142 LK(ub)ETPEPVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKETPEPVTK 10 1 Q5JPI3;Q5JPI3-2;E9PFZ1 Q5JPI3 C3orf38 Uncharacterized protein C3orf38 1 4992780.0 1689480.0 1087100.0 2216200.0 True False 1635848.3821745974 1521184.6991516086 1635710.7354251286 1.0 0.9299056781346925 0.9999158560469487 20.641607608299843 -9.960998942393044 4.555492381099026 1.0000006346165558 0.9649107671491497 0.2509014014447203 0.02858153546445345 550399853324.8463 125562676639.4281 3939650.264618191 0.009784656455950372 1.0939590303107125e-10 9.960998942393044 -0.035089867467406055 LK(ub)ETPEPVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKETPEPVTK 10 1 Q5JPI3;Q5JPI3-2;E9PFZ1 Q5JPI3 C3orf38 Uncharacterized protein C3orf38 1 9157310.0 786310.0 3845400.0 4525600.0 True False 1192889.7569610707 3159158.325752666 3631113.1763590584 1.0 2.648323792972064 3.043963748678209 20.186029289277148 -10.043719576374807 0.34158573972620176 2.1090501541796555e-16 3.133763616878074 0.9988592825846001 0.029895241402019965 1.4241200272774361 0.1536902850581972 1.518526773907508 0.12027969410773681 9.042331479366886e-11 10.043719576374807 3.133763616878074 LK(ub)ETPEPVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKETPEPVTK 10 1 Q5JPI3;Q5JPI3-2;E9PFZ1 Q5JPI3 C3orf38 Uncharacterized protein C3orf38 1 6728810.0 1773010.0 1303900.0 3651900.0 True False 2428539.7107936544 1246289.3865793047 2789396.4332413697 1.0 0.5131846850352771 1.1485900028086369 21.21165764641946 -6.701994216608948 1.8238404318651165 0.6983010279466488 1.1467682346650683 0.42703928000381175 0.20541637439216345 0.39137274741643496 2.53238337323942 0.08980774651579707 0.2303878940428648 1.9861213658630135e-07 6.701994216608948 0.44846720671841944 LK(ub)ETPEPVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKETPEPVTK 10 1 Q5JPI3;Q5JPI3-2;E9PFZ1 Q5JPI3 C3orf38 Uncharacterized protein C3orf38 1 8774180.0 1689480.0 3699700.0 3385000.0 True False 1404877.4766543745 3679768.9817670523 4092787.849528352 1.0 2.6192810710654895 2.913270315412176 20.42201288373412 -10.238413813477932 0.37954383253153495 1.4726296445281552e-20 2.952935999572512 0.9990490360083185 0.02594179043405449 1.62905781533349 0.17509098199378556 1.7734326572755936 0.0792669308855926 5.7754547628185516e-11 10.238413813477932 2.952935999572512 LK(ub)GDDLQAIKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKGDDLQAIKK 11 2 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-3;G3V2D6;G3V5V7;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 9937600.0 4254100.0 3730500.0 1953000.0 True False 5507016.310847678 3522894.3956269473 1597574.0394722386 1.0 0.6397101800275363 0.2900979313108896 22.392839450837155 -7.465388040498729 0.2919890815514406 1.0921926523795675 8.482134966478561e-12 0.9997655256309578 0.004437991963259832 0.12201111812018897 0.028335293547670923 0.02144709576093987 0.062394674356394515 3.424616615895508e-08 7.465388040498729 -1.0921926523710854 down LK(ub)GEATVSFDDPPSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKGEATVSFDDPPSAK 16 1 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 1 8307300.0 2735800.0 2952200.0 2619300.0 True False 2648953.526501207 4131028.8555196174 1933226.7526843383 1.0 1.5594946510730092 0.7298077272189007 21.336991102471355 -6.72503840236417 1.7410511539837288 1.3385478759788405 0.7307099116077342 0.5362000684873793 0.2353048226465285 0.3456390819224872 2.050121524486182 0.10719935687411071 0.26754259025230365 1.883482535726764e-07 6.72503840236417 -0.6078379643711063 LK(ub)GEATVSFDDPPSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKGEATVSFDDPPSAK 16 1 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 1 32560900.0 5217400.0 9005500.0 18338000.0 True False 6754027.150329491 8504336.00852928 15000672.163769536 1.0 1.259150403047225 2.2209967223832874 22.68731654813166 -6.946595825558414 0.5950440787509563 0.9890371740881814 2.539929940337899 0.9989063430932523 0.017370803110966403 0.08488216343099841 0.04184641446976538 0.017916635309846735 0.08070330413726862 1.1308478441825974e-07 6.946595825558414 1.5508927662497176 up LK(ub)GEMMDLQHGSLFLQTPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKGEMMDLQHGSLFLQTPK 19 1 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 1 17749200.0 7235300.0 5319600.0 5194300.0 True False 7005619.3619029885 7443744.021347525 3833757.0043401956 1.0 1.062539032855123 0.5472402661766659 22.7400811732773 -6.876560750266588 1.0988479273884106 1.0372452311514004 0.5130534767421736 0.9708016132672491 0.03923256278080615 0.13071787313249295 0.29109383050751086 0.02758373763989972 0.06615674950875487 1.3287376767679087e-07 6.876560750266588 -0.5241917544092268 LK(ub)GEMMDLQHGSLFLQTPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKGEMMDLQHGSLFLQTPK 19 1 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 1 38354000.0 10758000.0 10371000.0 17225000.0 True False 16320672.515149515 8520214.021007149 13820471.200014308 1.0 0.522050424888946 0.8468077027576886 23.960197170925415 -9.945115544980721 5.6273013274141155 1.0000003655479093 0.684429063822905 0.5573201250293842 0.1325816035070716 6.080015360766329e-07 1.1421657172884782e-07 0.12837173288779463 0.042790528532818 1.1347088837709254e-10 9.945115544980721 -0.31557130172500425 LK(ub)GEMMDLQHGSLFLQTPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKGEMMDLQHGSLFLQTPK 19 1 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 1 18166900.0 7235300.0 5928200.0 5003400.0 True False 6016472.528137293 5896263.609944433 6049587.8068922255 1.0 0.9800200337272916 1.0055041020465167 22.520486448711576 -6.6975894933683 1.8393046800610244 0.987563857231864 1.0054252440782827 0.4061348156985046 0.008437614114041288 0.4006039700666768 2.6330634946493876 0.0036619443261651334 0.009446252972494497 2.006367603078189e-07 6.6975894933683 0.017861386846418692 LK(ub)GEMMDLQHGSLFLQTPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKGEMMDLQHGSLFLQTPK 19 1 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 1 29546400.0 10758000.0 6784400.0 12004000.0 True False 13926443.07188343 6406842.176033094 9819395.171441229 1.0 0.46004871042542694 0.7050899587753272 23.731323493017864 -10.373965241017192 5.940073044999798 1.0000797796548486 0.5825693346003794 0.79463040915595 0.10003767073197904 0.00010571375407501095 1.114141192971023e-05 0.0968794532276332 0.032287019394861116 4.2270244411987636e-11 10.373965241017192 -0.4175104450544692 LK(ub)GEMMDLQHGSLFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKGEMMDLQHGSLFLR 16 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 1 16001500.0 4428600.0 5427200.0 6145700.0 True False 5805937.48662341 4617482.915059907 5509801.917717127 1.0 0.7953035880421305 0.9489943580018619 22.469097607664235 -10.484768683403004 4.786813885434742 1.0004369057902587 0.8721489730219768 0.47989293439157743 0.06274399409620203 0.00029354848814470714 3.1596262595985674e-05 0.06095782686849305 0.020250537017417764 3.275150915322226e-11 10.484768683403004 -0.12828793276828188 LK(ub)GEMMDLQHGSLFLR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LKGEMMDLQHGSLFLR 16 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 1 48544700.0 21159600.0 19754600.0 7630500.0 True False 20487900.08017944 27642714.798878092 5631843.139906792 1.0 1.3492214766129407 0.27488630449516843 24.28826878622963 -6.819171725932638 1.375397770872195 1.1883895341836899 0.25183615040875507 0.8824771353445648 0.15339467445404578 0.19456202595858532 0.7234262494352446 0.08764493779790539 0.20205902501286868 1.5164506237349843e-07 6.819171725932638 -0.9365533837749348 down LK(ub)GEMMDLQHGSLFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKGEMMDLQHGSLFLR 16 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 1 73284900.0 25036000.0 18517900.0 29731000.0 True False 37981442.37676922 15213236.063986931 23854654.818439774 1.0 0.40054392650690585 0.6280607930000603 25.178791358279764 -10.209156720690226 5.452542464698726 1.0000236733342527 0.5143023597534427 0.8586844168274237 0.09288337179770385 2.6731281614841857e-05 3.877048787826151e-06 0.08993831357041122 0.029977979342649005 6.177934212909162e-11 10.209156720690226 -0.48572131358080994 LK(ub)GEMMDLQHGSLFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKGEMMDLQHGSLFLR 16 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 1 25176500.0 4428600.0 16240200.0 4507700.0 True False 6065973.098415 15522654.264840288 3443074.098995625 1.0 2.5589718274379187 0.567604577721467 22.532307669187126 -6.697843480000506 1.838391100830097 1.970068464626738 0.5737169285651708 0.40748552493059986 0.6583198318566217 0.39999157643319044 2.62660776433664 0.2858364390765267 0.7371052420108737 2.005194570516445e-07 6.697843480000506 -1.3963515360615673 LK(ub)GEMMDLQHGSLFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKGEMMDLQHGSLFLR 16 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 1 43625800.0 16927200.0 18466200.0 8232400.0 True False 14075716.8021071 18366718.915346287 9953756.777683077 1.0 1.3048514099542579 0.7071580735549485 23.74670505724624 -6.768044991588314 1.581825531035335 1.1752911543129783 0.7040332072799877 0.7230618871358321 0.1284172524502587 0.2696053349149985 1.331025614287393 0.06400033102673017 0.15262914962270907 1.705905653207957e-07 6.768044991588314 -0.4712579470329905 LK(ub)GEMMDLQHGSLFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKGEMMDLQHGSLFLR 16 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 1 72208100.0 25036000.0 19625100.0 27547000.0 True False 32409595.53334018 18532945.933150616 22533728.656088963 1.0 0.5718351503055794 0.6952795394471436 24.949917680372213 -10.473352752921125 9.095574956737044 1.000005940821583 0.6335573448763642 0.9215636671590709 0.050395960834399435 6.07134162643281e-06 3.51513382261967e-07 0.04879646960599623 0.01626522641897919 3.3623835097595764e-11 10.473352752921125 -0.3664485959452187 LK(ub)GIEEEEILPGFILCDPNNLCHSGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKGIEEEEILPGFILCDPNNLCHSGR 26 1 P15170-2;P15170-3;P15170;H3BR35 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 1 60724000.0 13443000.0 16902000.0 30379000.0 True False 20394013.814942833 13885706.044071244 24374577.334411286 1.0 0.6808716601877112 1.1951829372868163 24.281642409209546 -6.738897343156439 1.6909380574307842 0.8098774805280927 1.195401106593763 0.5999189149820198 0.1340874264976561 0.31980247679734725 1.795044600714764 0.06274614790519849 0.1541479899253515 1.8243268786626883e-07 6.738897343156439 0.38552362606567037 LK(ub)GIEEEEILPGFILCDPNNLCHSGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKGIEEEEILPGFILCDPNNLCHSGR 26 1 P15170-2;P15170-3;P15170;H3BR35 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 1 52208000.0 13443000.0 15586000.0 23179000.0 True False 17402228.501146033 14718625.398804894 18960659.836624164 1.0 0.8457896870987294 1.0895535497293063 24.052768731301995 -6.735721619439493 1.702384127483 0.9077983674530339 1.0895683718608633 0.5856951667578991 0.0648018344369736 0.3255522933600805 1.8508092580933428 0.03013508735706914 0.07429826959226703 1.837715932486996e-07 6.735721619439493 0.18177000440782942 LK(ub)GQDPGAPQLQSESKPPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKGQDPGAPQLQSESKPPK 19 2 A0A0A0MRK1;E9PAV9;Q5T3I0;Q5T3I0-3;F8W895 A0A0A0MRK1 GPATCH4 G patch domain-containing protein 4 1 14147600.0 2466100.0 4243200.0 7438300.0 True False 3741253.9960596957 3485967.8077270784 5968116.744677297 1.0 0.9317645397501785 1.595218274664843 21.83509048400109 -6.881536208948661 1.0712318648530512 0.9567892176602248 1.643637091987385 0.9749020298209847 0.04720649919876505 0.1262763009574571 0.26415721883761156 0.03389883235410256 0.08230292577746935 1.3136019699001396e-07 6.881536208948661 0.6868478743271602 LK(ub)GTIDVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKGTIDVSK 9 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 3806510.0 713960.0 708150.0 2384400.0 True False 936008.4739984758 602496.7803470796 2137685.160779848 1.0 0.6436873138266702 2.283830991025119 19.83616206550643 -6.849816624093375 1.2360044171886573 0.8098920764902907 2.349154980645878 0.9400345295364021 0.1724854062031343 0.15765887993272157 0.4635861861013325 0.10920474629645051 0.2526724464895945 1.4131340984741971e-07 6.849816624093375 1.5392629041555872 up LK(ub)GTIDVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKGTIDVSK 9 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 8987910.0 697280.0 995730.0 7294900.0 True False 675145.228071775 1393330.181663354 5384146.847690989 1.0 2.0637488405905287 7.97479804910744 19.364838342945173 -6.937480100958066 0.6826033966056491 0.9298733221872922 9.457210903736135 0.9978148717052296 0.14342004722048415 0.08893528153849378 0.05998707740146319 0.13707446789825845 0.5146549041913405 1.1548348971314652e-07 6.937480100958066 8.527337581548842 LK(ub)GTIDVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKGTIDVSK 9 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 41043400.0 2165900.0 5946500.0 32931000.0 True False 3285828.6484999345 4885300.614783435 26422173.415829923 1.0 1.4867788729682239 8.041251155288432 21.64782581698737 -6.921799266186911 0.8112690802207579 0.8645435841231265 9.143241271172519 0.9946663159230147 0.23448399429485706 0.09712470735861511 0.10021261298534642 0.20398094386438914 0.621938797457684 1.197293800634378e-07 6.921799266186911 8.278697687049393 up LK(ub)GTIDVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKGTIDVSK 9 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 4878130.0 713960.0 683970.0 3480200.0 True False 977930.3060435293 653749.9438136728 2658248.4369688705 1.0 0.6685036139830738 2.718239142954373 19.89937212702932 -6.865453440636191 1.1579580732692825 0.816817041829244 2.8283090812330136 0.9599265157788319 0.17983937811155387 0.14128421590883697 0.3569479299421935 0.12084003920112628 0.28402706674518796 1.363159138435907e-07 6.865453440636191 2.0114920394037696 up LK(ub)GTIDVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKGTIDVSK 9 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 6655780.0 697280.0 1646100.0 4312400.0 True False 579819.2147415546 1637232.1325747338 5214102.901715231 1.0 2.8236941635411386 8.99263558217769 19.14524361837945 -6.948725335782851 0.5726663180594612 0.9240510419282663 11.193584888477522 0.9990974221889077 0.10274503511489842 0.08400165317686302 0.03811201451777617 0.1085239605389772 0.5143353296320736 1.1253164415417982e-07 6.948725335782851 10.269533846549256 LK(ub)GTIDVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKGTIDVSK 9 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 43396800.0 2165900.0 4827900.0 36403000.0 True False 2803800.246271825 4559223.120934819 29778027.526322532 1.0 1.6260869963889746 10.620595231745902 21.41895213907982 -6.920960743453632 0.8175665045059125 0.8083295101080982 12.103599992917216 0.9944436870034169 0.3276108033746909 0.0976099541447435 0.10270833057512498 0.2837151329200431 0.8578305512052268 1.1996077326372638e-07 6.920960743453632 11.295270482809117 up LK(ub)GTSPSSSSRPQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKGTSPSSSSRPQR 14 2 Q8N1F7;H3BVG0;Q8N1F7-2 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 7073400.0 1431200.0 3478400.0 2163800.0 True False 1876317.059760516 2959436.278697004 1939910.7326352308 1.0 1.5772580989455653 1.0338928181374802 20.839472204157506 -10.241521452198494 4.163325275070021 0.9997907660108207 1.30557545843408 0.29661110994463746 0.22182794705333844 156575038.33471432 118.31601275239895 318933.30294912745 0.07593760654408971 5.734275410991412e-11 10.241521452198494 0.30578469242325923 LK(ub)GTSPSSSSRPQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKGTSPSSSSRPQR 14 2 Q8N1F7;H3BVG0;Q8N1F7-2 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 5874500.0 1431200.0 1618300.0 2825000.0 True False 1960353.3167257248 1546798.1549975402 2157793.182701299 1.0 0.789040496833028 1.100716469980701 20.902682265680397 -6.724408853419946 1.7433551563582543 0.872259946769072 1.1003573712064323 0.5332041754197102 0.08872852858091053 0.34685927362516233 2.06249741945127 0.040374410891425475 0.10083677258799603 1.8862147930506492e-07 6.724408853419946 0.22809742443736025 LK(ub)HGQFTLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKHGQFTLR 9 1 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 1 17603600.0 3778300.0 12542000.0 1283300.0 True False 5731957.330729629 10303782.108906733 1029655.1925096291 1.0 1.7976027235351297 0.17963413422314553 22.45059643939634 -6.772648876181404 1.564246095640293 1.4559245392958478 0.16958637061307477 0.7406410312256169 0.3364026612745103 0.262151687615468 1.2662639092871983 0.1694752542367642 0.4024604182335753 1.6879171421756268e-07 6.772648876181404 -1.286338168682773 LK(ub)HILILQNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKHILILQNK 10 1 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 7011900.0 2753400.0 1287800.0 2970700.0 True False 2665994.82413496 1802025.255788281 2192584.550910309 1.0 0.675929765307398 0.8224264094817741 21.346242548850057 -10.061702075613002 4.552499236713509 1.000011281007247 0.7491780873918891 0.7962733471160037 0.05980700459774788 18671518.04045193 20633419.692555673 2028.4357160741445 0.02047352912059683 8.67556812394729e-11 10.061702075613002 -0.25083319361535794 LK(ub)HILILQNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKHILILQNK 10 1 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 7084500.0 2753400.0 2551400.0 1779700.0 True False 2289574.09630191 2537655.101786754 2151827.041596931 1.0 1.1083524686471344 0.9398372584108694 21.126647824284333 -6.733075882776896 1.712014801211103 1.0649817083173418 0.9398798814901345 0.573462865668225 0.04553883060799432 0.33050370585246897 1.899134492047746 0.021067295942030332 0.05209601492941502 1.8489455308774595e-07 6.733075882776896 -0.12510182682720739 LK(ub)HVSHGEELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKHVSHGEELR 11 1 Q9NZ53;Q9NZ53-2 Q9NZ53 PODXL2 Podocalyxin-like protein 2 1 10027110.0 2683210.0 4593100.0 2750800.0 True False 3517714.2942426004 3907827.38376357 2466173.6035368275 1.0 1.1108995947054208 0.7010727413460449 21.74620688243035 -6.834629403811865 1.3069572774810234 1.0590974658454049 0.6889533517873488 0.9148396803092181 0.05050900650867506 0.1751702465695858 0.5835057919064992 0.030326502273624413 0.06980300893815503 1.4634254255293647e-07 6.834629403811865 -0.37014411405805603 LK(ub)HVSHGEELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKHVSHGEELR 11 1 Q9NZ53;Q9NZ53-2 Q9NZ53 PODXL2 Podocalyxin-like protein 2 1 9153510.0 2683210.0 3172400.0 3297900.0 True False 3675265.248023776 3032232.8782760906 2519003.9423825145 1.0 0.8250378336384157 0.6853937804181633 21.80941694395324 -6.973674639835601 0.14575316490697196 1.172325510428983 0.33444647881791506 0.9999987154013346 0.0001457623291300602 0.0751273819424791 0.00443724367711623 0.007438443449663392 0.01773183108844397 1.0624912451059918e-07 6.973674639835601 -0.8378790316110678 LK(ub)IAQLCNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKIAQLCNK 9 1 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 8942300.0 2241600.0 1878100.0 4822600.0 True False 2901795.3885419117 1773582.0840174167 3944936.2840546896 1.0 0.6112016343470043 1.3594812024416831 21.46851436497179 -6.765511580607699 1.5917215159490825 0.7757147410956441 1.3629845525756705 0.7130385781255902 0.16368583563568487 0.2737650409576482 1.3681295140773881 0.0810935112122545 0.19383516353852961 1.7158859548377413e-07 6.765511580607699 0.5872698114800264 LK(ub)ISPVTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKISPVTLK 9 1 Q5VWP2 Q5VWP2 FAM46C Protein FAM46C 1 19976500.0 1617300.0 0.0 18359200.0 True False 2120295.9619554793 0.0 16459566.097881848 1.0 0.0 7.762862540520867 21.01583422705785 -6.874534278113763 1.1098905815300906 0.41559300503594826 8.25833017712869 0.9689998954592032 0.6070840932886189 0.1325786763566592 0.302517508562829 0.4232346176951366 1.010653441806062 1.3349522199298252e-07 6.874534278113763 7.8427371720927415 up LK(ub)ISPVTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKISPVTLK 9 1 Q5VWP2 Q5VWP2 FAM46C Protein FAM46C 1 12709700.0 3144500.0 9565200.0 0.0 True False 3044679.5687122797 13384634.241859026 0.0 1.0 4.396073195814146 0.0 21.537858971854796 -6.700498372852099 1.8293761185545874 3.1080047301492955 0.013246792599396654 0.4195457500590486 1.4334325550220501 0.39464537038004327 2.5680971346161594 0.6250594130733426 1.606330346863979 1.9929739731196927e-07 6.700498372852099 -3.0947579375498986 LK(ub)ISPVTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKISPVTLK 9 1 Q5VWP2 Q5VWP2 FAM46C Protein FAM46C 1 7147200.0 3144500.0 4002700.0 0.0 True False 2614791.0749696246 3981136.66062626 0.0 1.0 1.5225448406704953 0.0 21.318264247289072 -6.8336813548961945 1.4441653237312368 1.2820973362305512 6.142622129848957e-23 0.8694688609853702 0.22822087043022454 0.1908704593765162 0.7987093732119248 0.12654010624141235 0.2729217454635725 1.4666235189167889e-07 6.8336813548961945 -1.2820973362305512 down LK(ub)IVGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKIVGTR 7 1 P62487 P62487 POLR2G DNA-directed RNA polymerase II subunit RPB7 1 44263580.0 927580.0 16415000.0 26921000.0 True False 1407206.6751814822 13485614.999019634 21600052.550106548 1.0 9.58325115767408 15.34959500339271 20.4244028007859 -8.156985945889803 0.3854988292186263 1.2381942814429995e-13 17.247332370101248 0.9970377039034736 0.32088529276047745 0.10460376978704744 0.10088063803777418 1.0525663411664783 1.4473002973403564 6.966490578561281e-09 8.156985945889803 17.247332370101123 LK(ub)IVGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKIVGTR 7 1 P62487 P62487 POLR2G DNA-directed RNA polymerase II subunit RPB7 1 41194580.0 927580.0 11492000.0 28775000.0 True False 1200770.595335344 10852460.097720105 23538245.25643297 1.0 9.037912936808128 19.602616309786757 20.195529122878348 -7.137856957520648 0.35301793021272915 1.5250269920496085e-24 27.20570781263421 0.9998166963662098 0.10313718825582696 0.09625756820296158 0.020994646682252163 0.22816180321286977 1.1657725837563235 7.280195510176712e-08 7.137856957520648 27.20570781263421 LK(ub)KPDQAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKKPDQAIK 9 2 C9JIF9;P13798;H7C393;H7C1U0;C9JLK2 C9JIF9 APEH Acylamino-acid-releasing enzyme 1 14381500.0 4480000.0 4324400.0 5577100.0 True False 4337784.852228015 6051155.471448079 4116290.200586355 1.0 1.394987459633925 0.9489383039530203 22.048527068548957 -6.673016930409418 1.9268170418456492 1.251462625899146 0.9507204433599291 0.29244805489773207 0.1676663382706699 0.454209179157917 3.253898506478953 0.06998486596575948 0.1862401045739994 2.1231616916707292e-07 6.673016930409418 -0.3007421825392168 LK(ub)KPDQAIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKKPDQAIK 9 2 C9JIF9;P13798;H7C393;H7C1U0;C9JLK2 C9JIF9 APEH Acylamino-acid-releasing enzyme 1 20439800.0 0.0 5473800.0 14966000.0 True False 0.0 4496957.623005393 12007963.540169165 0.0 LK(ub)KPDQAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKKPDQAIK 9 2 C9JIF9;P13798;H7C393;H7C1U0;C9JLK2 C9JIF9 APEH Acylamino-acid-releasing enzyme 1 14936500.0 4480000.0 5720300.0 4736200.0 True False 3725318.4976511053 5689483.608509347 5726517.522285436 1.0 1.5272475661065466 1.5371887063874219 21.828932343983233 -11.426492316231101 0.6354935742265715 9.089886873495353e-15 1.535766481957445 0.9999656061333456 0.0014715580052769728 4.447454514769539 0.31881476013244797 6.198315199780111 0.001656444202551481 3.7454817368292475e-12 11.426492316231101 1.535766481957436 LK(ub)KPDQAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKKPDQAIK 9 2 C9JIF9;P13798;H7C393;H7C1U0;C9JLK2 C9JIF9 APEH Acylamino-acid-releasing enzyme 1 14347100.0 0.0 3551100.0 10796000.0 True False 0.0 3353478.1633322234 8831238.776314529 0.0 LK(ub)LIANNTTVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKLIANNTTVER 12 1 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 1 13508600.0 4022900.0 4236300.0 5249400.0 True False 5274060.857819011 3604260.552968067 4706242.443800433 1.0 0.683393811738938 0.8923375309223509 22.33048278799861 -10.33174992651933 4.92916791026079 1.0001078187110792 0.7878656713305641 0.5788347139228103 0.08530091616006785 0.00010112146963317174 1.3709042710913674e-05 0.08263411092480205 0.027530752308641788 4.658542623981242e-11 10.33174992651933 -0.21224214738051517 LK(ub)LIANNTTVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKLIANNTTVER 12 1 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 1 30372400.0 6118300.0 4967100.0 19287000.0 True False 5924077.915488091 6950488.933084313 14235156.102402505 1.0 1.173260890933379 2.40293195084178 22.498159184891694 -6.932394462908176 0.7268726825826997 0.9828612807570725 2.6714894055372023 0.9969882295017639 0.03427390154797001 0.09141340658755104 0.07172904550980612 0.03168235343211302 0.10983571375075292 1.1684376352141586e-07 6.932394462908176 1.6886281247801298 up LK(ub)LIANNTTVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKLIANNTTVER 12 1 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 1 31845500.0 6032700.0 6989800.0 18823000.0 True False 9152046.949446216 5742415.57844333 15102625.799586015 1.0 0.6274460358609502 1.6501910319089725 23.12566302239759 -6.808121776705174 1.4222894935306118 0.796506287818013 1.6673474150671892 0.8549036284814728 0.16098653682412364 0.20936860057803225 0.8350744842199143 0.08900737228071204 0.20608496446768318 1.5555293980974108e-07 6.808121776705174 0.8708411272491762 LK(ub)LIANNTTVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKLIANNTTVER 12 1 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 1 21513500.0 4022900.0 4040600.0 13450000.0 True False 5510274.844784731 3862072.931522622 10273387.011445116 1.0 0.7008857162865351 1.8644055515975746 22.3936928495215 -6.838490673074588 1.2894581073946862 0.8408407320977846 1.901530412721682 0.92182497200692 0.137936409257204 0.17056116476774688 0.5515441824361148 0.08390328708122306 0.19321819162947945 1.4504719243627247e-07 6.838490673074588 1.0606896806238975 LK(ub)LIANNTTVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKLIANNTTVER 12 1 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 1 22910800.0 6118300.0 8807800.0 7984700.0 True False 5087637.536647041 8760350.633188576 9654263.852918472 1.0 1.7218896924331604 1.8975927006154258 22.27856446032597 -11.053657265976215 0.2669664889487568 4.197536532158779e-11 1.969480125303148 0.9992329619691268 0.010756824210654862 3.033897063896949 0.1407961126294424 1.9242075023189755 0.0736329842499617 8.837770794018931e-12 11.053657265976215 1.9694801252611727 LK(ub)LSEELSGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKLSEELSGGR 11 1 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 6565500.0 1920400.0 3027900.0 1617200.0 True False 2517662.9971800554 2576149.1226617596 1449867.657277795 1.0 1.0232303233384343 0.5758783677171012 21.263653752764192 -6.894654067990398 0.9944258497792715 1.0214242064170034 0.5336991604399215 0.9837143876715644 0.026241122567501975 0.11544883889967728 0.20043114350701347 0.01997298536691002 0.05070485164010632 1.27451787858051e-07 6.894654067990398 -0.4877250459770819 LK(ub)LSEELSGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKLSEELSGGR 11 1 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 13179260.0 4291460.0 5242600.0 3645200.0 True False 4155229.951326436 7335997.5197978355 2690412.7663440444 1.0 1.7654853295077044 0.6474762643365161 21.986496887585396 -6.722430379258416 1.750903602598464 1.4644996699938675 0.6490085719732228 0.5238707040293239 0.3220251067978003 0.35058463275337304 2.1018019022482783 0.14597271778904053 0.365356643864199 1.8948272453737277e-07 6.722430379258416 -0.8154910980206447 LK(ub)LSEELSGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKLSEELSGGR 11 1 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 24031200.0 4448500.0 8740700.0 10842000.0 True False 6748699.728912676 7180853.793599201 8699073.947782585 1.0 1.0640351596671427 1.2889999995872015 22.686178134398446 -6.947858798436714 0.581883836580133 0.9973294472152239 1.3668687483838486 0.9990222981094246 0.0038751071395358512 0.08435725595998422 0.0396110020489899 0.004051873549068471 0.018802315844619895 1.1275639999066622e-07 6.947858798436714 0.36953930116862477 LK(ub)LSEELSGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKLSEELSGGR 11 1 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 5196300.0 1920400.0 1773000.0 1502900.0 True False 2630423.7768586376 1694662.9974730487 1147945.9731970907 1.0 0.6442547441906439 0.4364110388965598 21.326863814287083 -9.581093635236503 0.12442212624840097 1.6655694975792417 1.480087215028944e-13 0.9998829676068695 0.002517487163446598 1.0472065624870988 0.050475646446780056 0.4518406353826803 0.2165723649309802 2.623652814720685e-10 9.581093635236503 -1.6655694975790936 LK(ub)LSEELSGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKLSEELSGGR 11 1 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 13138260.0 4291460.0 7290700.0 1556100.0 True False 3568539.1339129037 7251423.552009364 1881473.3154065185 1.0 2.032042603399497 0.5272390871452999 21.766902163019672 -6.722119613657876 1.7516823011205749 1.626457996201377 0.5293003884025256 0.5224951439551335 0.4341783917780621 0.3512200455862836 2.107253447499356 0.19672080929428779 0.49261704292285824 1.8961836012120068e-07 6.722119613657876 -1.0971576077988514 LK(ub)LSEELSGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKLSEELSGGR 11 1 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 23946500.0 4448500.0 16595100.0 2902900.0 True False 5758670.943044562 15671568.096734682 2374601.986269306 1.0 2.7213862802254947 0.41235243509396863 22.457304456490895 -6.707153571846875 1.8057992947352541 2.061355971508046 0.418316853679815 0.45140255101562143 0.7257147811578375 0.38080705071354604 2.4189189414588963 0.3200624091775879 0.8157914236797894 1.9626661313365957e-07 6.707153571846875 -1.6430391178282309 LK(ub)LSPSPSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKLSPSPSSR 10 1 Q03252;P20700 Q03252;P20700 LMNB2;LMNB1 Lamin-B2;Lamin-B1 1 46642000.0 12688000.0 18364000.0 15590000.0 True False 12285226.385060057 25696840.966994856 11506511.310025146 1.0 2.0916864013384835 0.936613697572403 23.55042110730797 -6.658955456311517 1.9770985109883643 1.7033206963213254 0.9414839830198211 0.2310365856282498 0.46493365453098706 0.48687795617683655 3.657617701120474 0.19008603772699378 0.5151832412913979 2.1930298533111096e-07 6.658955456311517 -0.7618367133015044 LK(ub)LSPSPSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKLSPSPSSR 10 1 Q03252;P20700 Q03252;P20700 LMNB2;LMNB1 Lamin-B2;Lamin-B1 1 44480500.0 12688000.0 25366000.0 6426500.0 True False 10550634.173704738 25229348.323243223 7770251.437221256 1.0 2.3912636821511764 0.7364724536262467 23.330826382742245 -6.683781147326302 1.88866572688812 1.87728778468219 0.7426126348602797 0.3413725928553869 0.58917364168326 0.43020451868103465 2.9701442646078364 0.25003011249345497 0.6562092419683891 2.0711848116042308e-07 6.683781147326302 -1.1346751498219103 LK(ub)LSPSPSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKLSPSPSSR 10 1 Q03252;P20700 Q03252;P20700 LMNB2;LMNB1 Lamin-B2;Lamin-B1 1 47205000.0 16316000.0 13460000.0 17429000.0 True False 21121383.636442654 12710939.16770907 14257100.836641913 1.0 0.6018042845345475 0.6750079010942651 24.332201011220857 -10.775750585889963 7.0596257035042225 1.009442873596572 0.6384060928144063 0.9701780797509537 0.029885251316276857 0.004452788412961903 0.0001414429320123635 0.029008814384225014 0.009645423387096964 1.6759050673154286e-11 10.775750585889963 -0.3710367807821656 LK(ub)LSSGNEENKKEEDNDEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKLSSGNEENKKEEDNDEIK 20 3 Q9UHD1;Q9UHD1-2;E9PPQ5 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 1 22428000.0 5366900.0 7798200.0 9262900.0 True False 8141979.672946269 6406550.282385301 7432083.7549267 1.0 0.7868541239021563 0.9128104040374392 22.956948189011847 -10.227044474619564 5.060203740885434 1.0000184188964516 0.849832264009048 0.6545993115661405 0.051421436038746465 1.0686387573347204e-05 1.6323851577470791e-06 0.04979469558641307 0.01659619711796397 5.92864608224743e-11 10.227044474619564 -0.1501861548874036 LK(ub)LVPLNQESVEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKLVPLNQESVEER 14 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BRD9;H3BV15 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 17716200.0 4284500.0 5036000.0 8395700.0 True False 5617020.991157017 4284648.43017425 7526993.501241138 1.0 0.7627972971651084 1.3400330020291944 22.421373763691925 -6.795100415728534 1.4756898172290183 0.8683036079620858 1.3470840335888294 0.8175070764478615 0.10120117442303458 0.22781687010784987 0.9798435116951836 0.05396302319301634 0.12589896093267877 1.6028747379411984e-07 6.795100415728534 0.4787804256267436 LK(ub)LVPLNQESVEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKLVPLNQESVEER 14 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BRD9;H3BV15 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 22163800.0 5907800.0 4490000.0 11766000.0 True False 5720260.122766218 6282880.415040672 8684131.627566129 1.0 1.09835571813164 1.5181357912385693 22.447649322847425 -6.9433880569499875 0.6272580316308733 0.9954199578982305 1.6435890803455024 0.9985747845336331 0.008482346649258921 0.0862545341567111 0.047823410667309496 0.008486686573263536 0.0356257528856774 1.139231390492457e-07 6.9433880569499875 0.648169122447272 LK(ub)LVPLNQESVEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKLVPLNQESVEER 14 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BRD9;H3BV15 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 77695500.0 9970500.0 18530000.0 49195000.0 True False 15125977.44118777 15223176.724449188 39471586.68706554 1.0 1.006425983619197 2.609523043422312 23.85052503661473 -6.907779390306921 0.9107267591147302 0.9468121962570003 2.807147793968859 0.9900561826972392 0.07550962151773347 0.10590473720401083 0.1468691670743688 0.06114984915456654 0.16631314586852755 1.236575420350754e-07 6.907779390306921 1.8603355977118587 up LK(ub)LVPLNQESVEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKLVPLNQESVEER 14 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BRD9;H3BV15 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 19387400.0 4284500.0 5311700.0 9791200.0 True False 5868595.434258915 5077011.530557022 7478720.216093791 1.0 0.865115271180411 1.2743628862939675 22.484583825214816 -6.817890603882291 1.380834542053364 0.9271348540706497 1.28290811099653 0.8794686016004365 0.05911661614906381 0.19625543579284546 0.7358259857844054 0.03364618013090417 0.07760138161558067 1.5209305945778958e-07 6.817890603882291 0.35577325692588024 LK(ub)LVPLNQESVEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKLVPLNQESVEER 14 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BRD9;H3BV15 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 24165600.0 5907800.0 6867800.0 11390000.0 True False 4912597.459915891 6830801.798248425 13771596.338590225 1.0 1.3904664190347433 2.8033227739416713 22.2280545982817 -6.947180247256912 0.5889871828137949 0.9836196574866181 3.281138989830345 0.998961018977918 0.024969138160461524 0.08463815407932597 0.04080342436507925 0.025913512157046775 0.11832644925268876 1.1293271075167096e-07 6.947180247256912 2.297519332343727 up LK(ub)LVPLNQESVEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKLVPLNQESVEER 14 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BRD9;H3BV15 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 86821500.0 9970500.0 13234000.0 63617000.0 True False 12907008.79793768 12497516.266379049 52039358.76554297 1.0 0.9682736303996274 4.031868233781476 23.62165135870718 -6.904559754471129 0.931982185607777 0.8880667632953346 4.384970909825387 0.9887017143500876 0.15271945229081382 0.10812659216638411 0.1590919791764042 0.1217633569495627 0.32471023881828903 1.2457768193516545e-07 6.904559754471129 3.496904146530052 up LK(ub)MIIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKMIIAK 7 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG63;S4R306 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 12232200.0 1205000.0 7076700.0 3950500.0 True False 1559896.254101089 6682875.424080753 3231549.535553031 1.0 4.284179416747077 2.071643884685943 20.573018650545656 -9.521813675348588 10.362094466601008 1.0000074515376485 3.17791165071651 0.5636863651686286 0.9032638485647569 0.0 0.0 0.874581460676001 0.29152715355866693 3.007366271325604e-10 9.521813675348588 2.1779041991788617 LK(ub)NITLDDASAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKNITLDDASAPR 13 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 60315700.0 13439400.0 36911000.0 9965300.0 True False 17619183.54733472 31404022.67795113 8934186.34990751 1.0 1.7823767255493326 0.507071529501093 24.070643737192793 -6.740658791585431 1.683958218441305 1.4651323254776254 0.5061611259114901 0.6081031979844983 0.3287163616154251 0.31659062956696826 1.7629518229998045 0.15440075679422416 0.37865969175632286 1.81694260383966e-07 6.740658791585431 -0.9589711995661353 LK(ub)NITLDDASAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKNITLDDASAPR 13 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 118911500.0 48116300.0 44060000.0 26735200.0 True False 46588874.39403103 61653387.769864604 19732449.081192043 1.0 1.3233500180412952 0.4235442332068912 25.473482138985737 -6.809518791053385 1.4166140034649017 1.1763217410516156 0.4079835434044194 0.858556169514038 0.13996456513830371 0.2074556265779134 0.8206335113676858 0.07769187235805526 0.17975185409736946 1.5505336968517572e-07 6.809518791053385 -0.7683381976471961 down LK(ub)NQDGEINR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKNQDGEINR 10 1 E9PN76;Q8ND24-2;Q8ND24 E9PN76 RNF214 RING finger protein 214 1 1892220.0 547770.0 746910.0 597540.0 True False 718131.7746122258 635473.9394323769 535712.2928084187 1.0 0.8848987914168229 0.745980489580329 19.453889072156727 -6.968618042088225 0.28930114578266486 1.0273715887183639 0.5992199010574458 0.9999695014130086 0.0005735148866046674 0.07675376506755661 0.010627360350037956 0.0024361288890417917 0.012607950280045136 1.074934391416437e-07 6.968618042088225 -0.42815168766091805 LK(ub)NQDGEINR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKNQDGEINR 10 1 E9PN76;Q8ND24-2;Q8ND24 E9PN76 RNF214 RING finger protein 214 1 1852650.0 547770.0 713950.0 590930.0 True False 750295.3719276482 682405.3282830709 451364.5045853732 1.0 0.9095155772184025 0.6015824187022958 19.51709913367962 -6.948587000805998 0.5741456312153232 1.003767375016808 0.4922521261497258 0.9990856894210925 0.005156631069781757 0.08405811888925888 0.03834899620901247 0.005437653360285561 0.025683598040816612 1.1256749434932251e-07 6.948587000805998 -0.5115152488670821 LK(ub)NWEPCDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKNWEPCDR 9 1 P98170 P98170 XIAP E3 ubiquitin-protein ligase XIAP 1 8540500.0 4388200.0 2741000.0 1411300.0 True False 6010636.12664604 2619893.556725114 1077980.0066358724 1.0 0.43587625361494403 0.17934541102180973 22.51908625380344 -9.530438340900545 0.2317217409661117 1.455804066793107 3.598732400625579e-15 0.9992349700664848 0.00948116461152948 0.9434342140701711 0.09327809536515921 0.4276412986516733 0.12134216382102671 2.94823202308868e-10 9.530438340900545 -1.4558040667931034 LK(ub)PGDLVGVNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKPGDLVGVNK 11 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PM69;E9PKD5 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 71300000.0 21530000.0 27958000.0 21812000.0 True False 28226038.4968166 23786775.37943045 19555103.47547817 1.0 0.8427245425217279 0.6928036847141563 24.750523326047556 -6.971706917523833 0.2135159774101221 1.075055567594605 0.4562707636634602 0.9999928097894404 0.0003362704179726625 0.07575261174384902 0.007013016170200434 0.004366615930156906 0.01541151747256375 1.067316153714884e-07 6.971706917523833 -0.6187848039311448 LK(ub)PGDLVGVNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKPGDLVGVNK 11 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PM69;E9PKD5 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 65605300.0 26867000.0 16366300.0 22372000.0 True False 26014121.79125228 22901448.939127024 16512102.054386325 1.0 0.8803468025135506 0.6347360939910267 24.632791668516685 -6.95953303481312 0.441965648152807 1.0086041659137832 0.49687140400249924 0.9997524851909223 0.0023920572358930104 0.07986835645382376 0.02175085165810385 0.0032463091292156162 0.020342971427317738 1.0976577932441233e-07 6.95953303481312 -0.5117327619112839 LK(ub)PGDLVGVNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKPGDLVGVNK 11 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PM69;E9PKD5 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 108772000.0 51956000.0 34938000.0 21878000.0 True False 78821050.49238789 28703040.92816009 17553803.71053197 1.0 0.364154508838119 0.2227045135896434 26.232077641422112 -13.99999999999991 0.2112023415559231 4.6956150066167694 0.1403551799875257 0.9994907207716004 0.007628828945110094 12.775106646255624 0.14565511836136474 19.602697897727836 0.08308776395938981 1.0000000000002086e-14 13.99999999999991 -4.555259826629244 LK(ub)PGDLVGVNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKPGDLVGVNK 11 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PM69;E9PKD5 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 69467000.0 21530000.0 23835000.0 24102000.0 True False 29490222.82637288 22781890.888195228 18409603.996271376 1.0 0.7725235249094679 0.624261271427485 24.813733387570448 -8.797793900177941 0.07960049785465718 1.6673150213485741 0.0006906310920292717 0.999988049688334 0.0005341559964744076 0.32282436174793355 0.0228936662104049 0.2552507772453169 0.21108315219481188 1.5929645087294486e-09 8.797793900177941 -1.6666243902565447 LK(ub)PGDLVGVNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKPGDLVGVNK 11 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PM69;E9PKD5 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 63184900.0 26867000.0 28206000.0 8111900.0 True False 22341100.90990901 28054048.679547347 9808060.784812124 1.0 1.255714693410854 0.43901421081993003 24.41319694395096 -6.822543912085797 1.3606927864619283 1.137486986536514 0.4201714053118238 0.8901692239868118 0.11304041922423845 0.1901907514216731 0.6912000398156717 0.06526912972032373 0.15035289137706767 1.5047213667556628e-07 6.822543912085797 -0.7173155812246903 down LK(ub)PGDLVGVNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKPGDLVGVNK 11 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PM69;E9PKD5 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 103497500.0 51956000.0 33551000.0 17990500.0 True False 67258066.20587249 31683857.356300663 14716413.59811842 1.0 0.47107892247925287 0.218805184690747 26.00320396351456 -9.598352326403779 0.20774844307213325 1.5107504247143426 4.86483735455314e-18 0.9994159665733668 0.007866750497599549 1.0250230674603624 0.08493955827926121 0.4595861110608137 0.1376132744176673 2.521434399804199e-10 9.598352326403779 -1.5107504247143426 LK(ub)PMYGPGYTGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKPMYGPGYTGLK 13 1 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 37777000.0 12709000.0 13672000.0 11396000.0 True False 16661622.074131062 11632190.893038586 10216851.238150984 1.0 0.6981427643289784 0.6131966739309092 23.990025523761897 -13.999999998590065 0.17786138569135096 2.5561257188784086 0.5442085473887266 0.9995008727336051 0.0037082269871796815 12.177809541950744 0.13367187014901402 6.545858878489376 0.06459558091631572 1.000000003246496e-14 13.999999998590065 -2.011917171489682 LK(ub)PMYGPGYTGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKPMYGPGYTGLK 13 1 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 50058000.0 21053000.0 13789000.0 15216000.0 True False 31938940.180465035 11328245.21605127 12208550.930590285 1.0 0.354684443254633 0.3822465886973125 24.928813105271416 -10.641166823960322 6.561503963306639 1.0027919765253706 0.36846551597597477 0.9985734949505705 0.011252198758490253 0.00046078278045312944 2.519909120212719e-05 0.010923577060910253 0.0036316315333207116 2.284721013219051e-11 10.641166823960322 -0.6343264605493958 LK(ub)PMYGPGYTGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKPMYGPGYTGLK 13 1 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 36535800.0 12709000.0 14211000.0 9615800.0 True False 17407860.74781108 13583111.030507324 7344746.083617387 1.0 0.7802860573902114 0.4219212337472851 24.05323558528479 -6.963827987961018 0.37762848249130126 1.0252820818812138 0.16430009579166416 0.9998869074221547 0.002533680418093737 0.07836096777515064 0.01627637821120528 0.004675799147204442 0.03031640993856736 1.086856012001117e-07 6.963827987961018 -0.8609819860895497 down LK(ub)PMYGPGYTGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKPMYGPGYTGLK 13 1 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 41644800.0 12960000.0 22250000.0 6434800.0 True False 10776814.225347852 22130134.833720773 7780286.928846388 1.0 2.053495065514731 0.7219468356934823 23.361427424810255 -6.6958317528711815 1.845620628471806 1.656839269276856 0.7261923334279018 0.39781823603053756 0.4450430802387153 0.40428785780233956 2.674291856032862 0.19258378473774718 0.49785991990925393 2.0145045244747434e-07 6.6958317528711815 -0.9306469358489543 LK(ub)PMYGPGYTGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKPMYGPGYTGLK 13 1 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 44597600.0 21053000.0 13921000.0 9623600.0 True False 27253523.51667243 13146284.11245752 7872203.546474664 1.0 0.4823700724207363 0.288850854153182 24.699939427363866 -13.999999999999998 0.13658287454050208 3.466198578530071 0.03920670350685011 0.9996169021726105 0.005875933637763906 11.932056376039238 0.1155278661906616 7.859302321992158 0.22270560325404407 1.0000000000000041e-14 13.999999999999998 -3.4269918750232207 LK(ub)QIEEQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKQIEEQTK 9 1 P26038 P26038 MSN Moesin 1 17930500.0 6166100.0 7439200.0 4325200.0 True False 8083816.812597339 6329300.357774477 3877669.7942480324 1.0 0.7829593995637398 0.4796830363851519 22.94660519849459 -6.966408685059569 0.33298956856761547 1.0356841494331468 0.21698555098807895 0.9999393079122659 0.0016623979183737734 0.07748612329518803 0.013191795415440495 0.004379378715291263 0.026389673157666774 1.0804167658848756e-07 6.966408685059569 -0.8186985984450679 down LK(ub)QIEEQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKQIEEQTK 9 1 P26038 P26038 MSN Moesin 1 23956900.0 7320300.0 9786700.0 6849900.0 True False 7087921.083429637 13694580.346966272 5055705.697404826 1.0 1.9321011317383159 0.713284704766848 22.756931110409752 -6.702322732674978 1.8224512156513994 1.577469981662441 0.7167317916904974 0.4286688303090157 0.39328622385423745 0.39071103838831117 2.524423924988768 0.1720519437700371 0.44123012581690246 1.984619559853154e-07 6.702322732674978 -0.8607381899719435 LK(ub)QIEEQTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKQIEEQTK 9 1 P26038 P26038 MSN Moesin 1 15146800.0 3819300.0 4178400.0 7149100.0 True False 5794157.328231137 3432731.874011788 5736077.25143815 1.0 0.5924471289873908 0.9899760960045042 22.46616742783261 -10.799731164138432 10.124148810052297 1.0019595432093693 0.7912116129972413 0.26889992656350037 0.1622905211946019 0.007230395572093778 0.00014302625282478081 0.15828224740241395 0.05237904048616793 1.5858745727137793e-11 10.799731164138432 -0.210747930212128 LK(ub)QIEEQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKQIEEQTK 9 1 P26038 P26038 MSN Moesin 1 15799300.0 6166100.0 5312400.0 4320800.0 True False 8445873.80258698 5077680.602242431 3300316.0296692965 1.0 0.6012025186413669 0.39076075570279134 23.009815260017483 -10.595884057142905 0.12571401236483123 1.8890660039570035 2.959983103959754e-20 0.9998105893199547 0.003477158571974115 2.510420250678156 0.06813279764602952 0.9181297812712114 0.24401803382882536 2.5358055198144116e-11 10.595884057142905 -1.8890660039570035 LK(ub)QIEEQTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKQIEEQTK 9 1 P26038 P26038 MSN Moesin 1 21457830.0 7320300.0 12062600.0 2074930.0 True False 6087153.7942757625 11997616.379561359 2508788.269607643 1.0 1.9709730992576 0.41214471564146404 22.53733638584403 -6.738267404258158 1.6931355141709175 1.5788793500298406 0.41158471006520503 0.597120527460036 0.40798014342625444 0.3209480362829408 1.8058913002548045 0.19068135885780804 0.4687904932809848 1.826974962799003e-07 6.738267404258158 -1.1672946399646356 LK(ub)QIEEQTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKQIEEQTK 9 1 P26038 P26038 MSN Moesin 1 8207000.0 3819300.0 2138800.0 2248900.0 True False 4944159.139658339 2019773.8998436958 1839623.2756626287 1.0 0.40851717001634985 0.3720801098222243 22.23729374992506 -13.908521116256841 0.3970309049264947 9.999941156134037 0.3697642404665284 0.9998319525105281 0.0037308456494803046 24.395386770389344 0.20710359989892063 188.39923376339638 0.009404301692372248 1.2344652915669464e-14 13.908521116256841 -9.630176915667509 LK(ub)QIEEQTKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKQIEEQTKK 10 2 P26038 P26038 MSN Moesin 1 5903500.0 2517600.0 1942000.0 1443900.0 True False 3448424.7555818055 1856196.0186647836 1102880.5580539494 1.0 0.5382736032329675 0.3198215522228715 21.71750605692691 -11.08664243152793 0.14112208232126694 2.027889882209466 7.207431472327668e-21 0.9997000222468416 0.00491087442694403 3.3856554053392744 0.08374399906092383 1.340833577948813 0.22200527194038305 8.19138933734156e-12 11.08664243152793 -2.027889882209466 LK(ub)QMLNELMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKQMLNELMR 10 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 4387200.0 0.0 1371900.0 3015300.0 True False 0.0 1167217.8676243152 2703305.6807999825 0.0 LK(ub)QMLNELMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKQMLNELMR 10 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 17683100.0 2101100.0 9306300.0 6275700.0 True False 2034401.7305839926 13022354.121713387 4631905.903035584 1.0 6.40107306533563 2.276790190158733 20.956173163708186 -6.577791987172766 2.2757528408319554 4.6828388573759625 2.2866533140407013 0.0 2.347689392255199 0.7059335150152336 6.873708066404922 0.8674634651057992 2.6255882356199556 2.6436746876839325e-07 6.577791987172766 -2.3961855433352612 LK(ub)QMLNELMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKQMLNELMR 10 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 34974100.0 14497300.0 15192000.0 5284800.0 True False 21993463.994597256 12480868.904362217 4240256.963589871 1.0 0.5674808164565696 0.1927962309453163 24.390571512344916 -7.828246933947522 0.3401591088065933 1.081988216977736 1.903652782214224e-21 0.9989325174870168 0.010776038442512232 0.11394469211681495 0.058157806266627095 0.03974580606427828 0.08184834242136863 1.4850909995990619e-08 7.828246933947522 -1.081988216977736 down LK(ub)QMLNELMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKQMLNELMR 10 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 12039400.0 0.0 6246600.0 5792800.0 True False 0.0 5970604.557256155 4424659.94646091 0.0 LK(ub)QMLNELMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LKQMLNELMR 10 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 23444200.0 4001700.0 14880100.0 4562400.0 True False 3327590.8553684014 14799937.947831396 5516376.745845834 1.0 4.447643532844388 1.6577689342264734 21.66604662683624 -6.593559590395203 2.2146262796312066 3.328198104185047 1.6661258616637158 0.002535423455609309 1.4926240249163873 0.6593233113621014 6.101215868248354 0.5614068349182308 1.662953037942921 2.5494142536835336e-07 6.593559590395203 -1.662072242521331 LK(ub)QMLNELMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKQMLNELMR 10 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 22681600.0 14497300.0 8184300.0 0.0 True False 18767040.63450603 7728836.510422092 0.0 1.0 0.41183032855012114 0.0 24.161697834437366 -8.234231811431247 0.5431486979979168 1.0289649958178804 1.809141192771968e-19 0.9914930381810763 0.03784868531132456 0.1353167703131957 0.1743969621327318 0.05580269048604684 0.0723723322523069 5.831337644777357e-09 8.234231811431247 -1.0289649958178804 LK(ub)QSQLLALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKQSQLLALK 10 1 Q96JB5;Q96JB5-4;Q96JB5-2;J3QRM1;Q96JB5-3 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 5300400.0 1683400.0 2074500.0 1542500.0 True False 1629961.3884465746 2902858.6683745855 1138472.9759919036 1.0 1.7809370755347391 0.6984662238391541 20.636406358715234 -6.713149776333323 1.7838925144627447 1.478564263757938 0.70076673724731 0.47998468034807973 0.32892814064248505 0.36883454208714156 2.289859150464234 0.14662479160448139 0.37109186907618796 1.935754259917186e-07 6.713149776333323 -0.777797526510628 LK(ub)QSQLLALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKQSQLLALK 10 1 Q96JB5;Q96JB5-4;Q96JB5-2;J3QRM1;Q96JB5-3 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 18771400.0 2027400.0 3997300.0 12746700.0 True False 3075714.0227936544 3283950.58395255 10227309.15792291 1.0 1.0677034859599057 3.325182081991323 21.55248993833348 -6.913303374107784 0.8729311725260284 0.9371928943726962 3.6385228358568713 0.9921097318278124 0.09597750836215742 0.10227407147389049 0.12721595917829956 0.07988471326947959 0.22590900933653899 1.2209464765181713e-07 6.913303374107784 2.7013299414841754 up LK(ub)QSQLLALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKQSQLLALK 10 1 Q96JB5;Q96JB5-4;Q96JB5-2;J3QRM1;Q96JB5-3 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 5012000.0 1478800.0 1729000.0 1804200.0 True False 2025552.3230673585 1652607.0629615942 1378085.1186653753 1.0 0.8158797203811544 0.6803502940760854 20.949883921815733 -6.974477362938749 0.10623831462464578 1.3024440076871109 0.19033531047565327 0.999999669185691 7.512391976600795e-05 0.07487466796093203 0.0031317047029102477 0.01128074875008341 0.021267367036232995 1.0605292157017751e-07 6.974477362938749 -1.1121086972114576 LK(ub)QSQLLALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKQSQLLALK 10 1 Q96JB5;Q96JB5-4;Q96JB5-2;J3QRM1;Q96JB5-3 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 7878020.0 1683400.0 3882500.0 2312120.0 True False 1399821.6872647058 3861584.2018840923 2795573.601964989 1.0 2.758625785709711 1.9970926492985155 20.41681163414951 -10.652941252947642 6.194569666821195 0.9902428233436446 2.3778592175035334 0.8136020202658416 0.3108946010714546 0.04138661238505166 0.002318736449883906 0.29737695769185635 0.10034080103129514 2.223610658315754e-11 10.652941252947642 1.3876163941598887 LK(ub)QSQLLALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKQSQLLALK 10 1 Q96JB5;Q96JB5-4;Q96JB5-2;J3QRM1;Q96JB5-3 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 22550500.0 2027400.0 7411200.0 13111900.0 True False 2624509.266028674 6998760.205031613 10725668.7394552 1.0 2.666692892123761 4.086733043120457 21.32361626042593 -7.215263330343308 0.19429797693081854 1.4375864611196772e-11 6.449118338137846 0.9999890128190342 0.004181459116960252 0.09633653178679519 0.009822143014567901 0.08491846037516194 0.21790234320567795 6.091674223442093e-08 7.215263330343308 6.44911833812347 LK(ub)QSQLLALKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKQSQLLALKK 11 2 Q96JB5;Q96JB5-4;Q96JB5-2;J3QRM1;Q96JB5-3 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 11001500.0 2340700.0 3339900.0 5320900.0 True False 3551013.028091698 2743868.750242196 4269221.782766682 1.0 0.7727002769451233 1.2022546098798592 21.759799222707223 -6.762957439320314 1.6014769131496844 0.8684557245301783 1.2040492921539259 0.7028546025407396 0.09564734163568307 0.27798593197994825 1.4058214403660818 0.04710982639479813 0.11287792405627005 1.7260070316778207e-07 6.762957439320314 0.3355935676237476 LK(ub)QSQLLALKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKQSQLLALKK 11 2 Q96JB5;Q96JB5-4;Q96JB5-2;J3QRM1;Q96JB5-3 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 15417500.0 2340700.0 3479200.0 9597600.0 True False 3030082.2920949585 3285579.4615374007 7850935.27969215 1.0 1.0843202081042476 2.5909973798975994 21.530925544799672 -6.9184306331664125 0.836282297101916 0.9648385956757631 2.8254047165899174 0.993733783204494 0.057860794747962165 0.09910407375819218 0.11046356564187162 0.04944305281971546 0.14595496257211277 1.2066167973058704e-07 6.9184306331664125 1.8605661209141542 up LK(ub)SDTAAAAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKSDTAAAAVR 11 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 15447000.0 3805600.0 5327700.0 6313700.0 True False 4989178.453482822 4532827.927211949 5660418.88928692 1.0 0.9085319295499832 1.1345392717583638 22.25037084206805 -6.796873429902548 1.4689404364169534 0.9493309670790792 1.1374130891773087 0.822772450871599 0.03907739242191626 0.22525679254391687 0.9599326359029493 0.02093263784725499 0.048770870241004474 1.5963443155139562e-07 6.796873429902548 0.1880821220982295 LK(ub)SDTAAAAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKSDTAAAAVR 11 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 22556500.0 6283200.0 8011300.0 8262000.0 True False 6083743.255249798 11210253.868377578 6097934.345312874 1.0 1.8426572914141304 1.0023326247456004 22.536527839383027 -10.253150927962425 3.6878364804735186 0.9993139528358012 1.4224949567576886 0.25208186916404385 0.3430611110747424 95206087.30197382 143149063.1128899 781673.0738702463 0.12231241742385748 5.582761463950495e-11 10.253150927962425 0.4231810039218874 LK(ub)SDTAAAAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKSDTAAAAVR 11 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 17641200.0 4959200.0 4072300.0 8609700.0 True False 7523468.966083799 3345566.2479748726 6907989.02123444 1.0 0.44468399657882085 0.9181920005752698 22.84296659109403 -10.199942135082848 7.858082355052995 1.0000001645407148 0.6814379985770479 0.3763613687293398 0.1933088331525063 5.572683473224549e-07 5.6788619309628805e-08 0.18717057048398103 0.06239015762287043 6.310414181407851e-11 10.199942135082848 -0.31856216596366693 LK(ub)SDTAAAAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKSDTAAAAVR 11 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 15162800.0 3805600.0 4191000.0 7166200.0 True False 5212633.162473039 4005827.762216331 5473691.152521778 1.0 0.7684844947569337 1.0500817882079554 22.313580903590942 -6.688297442149156 1.8727180609616976 0.8546184177757303 1.049081336924444 0.3623016624955815 0.09794971516851286 0.42036830646019296 2.857053374716185 0.04186527796227767 0.1092444737136714 2.0497578478135592e-07 6.688297442149156 0.19446291914871372 LK(ub)SDTAAAAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKSDTAAAAVR 11 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 22209300.0 6283200.0 12370800.0 3555300.0 True False 5224759.192955681 12304156.044988457 4298696.792150121 1.0 2.3549709356131903 0.8227550081056118 22.316933114817303 -6.673333117270408 1.9259140422213459 1.8624061249518544 0.8289007224126838 0.2937324844228717 0.5751281255575245 0.45351385702656455 3.2462293356282883 0.24016081402027625 0.6387905744198099 2.1216164924035668e-07 6.673333117270408 -1.0335054025391708 LK(ub)SDTAAAAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKSDTAAAAVR 11 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 11560300.0 4959200.0 4327000.0 2274100.0 True False 6419782.160446582 4086198.646261306 1860237.1342364652 1.0 0.6365011372873525 0.2897663951430808 22.61409291318648 -7.489895586446152 0.2889609852213891 1.096069120883863 1.4917681245644037e-11 0.9997574472103955 0.004516153523171229 0.12370776827653147 0.029173002714234147 0.02295421089154679 0.06424755204171301 3.236714650231635e-08 7.489895586446152 -1.0960691208689455 down LK(ub)SEDGVEGDLGETQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKSEDGVEGDLGETQSR 17 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 64578000.0 15696000.0 18150000.0 30732000.0 True False 20577608.000280224 15442090.748145884 27552147.44216002 1.0 0.7504317677708505 1.3389382984545541 24.2945719532122 -6.791538180994608 1.4906710171862319 0.8607935406796287 1.3454216957654945 0.8061140374584609 0.10619686235931187 0.23307293544294547 1.0231875881085892 0.05607577771859428 0.1311137928720215 1.6160761425447403e-07 6.791538180994608 0.4846281550858659 LK(ub)SEDGVEGDLGETQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKSEDGVEGDLGETQSR 17 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 131001000.0 21411000.0 34922000.0 74668000.0 True False 20731319.524788868 48866536.71582419 55110210.80801526 1.0 2.3571358618728278 2.6583069515724187 24.30530860947144 -10.292370094327644 0.3335618886565023 1.7488730724387743e-25 2.7287552677059734 0.9990037908189052 0.02276633209896823 1.7400960148197797 0.15571535067424483 1.646868068349593 0.09447071665628527 5.100701463617001e-11 10.292370094327644 2.7287552677059734 LK(ub)SEDGVEGDLGETQSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKSEDGVEGDLGETQSR 17 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 257382000.0 44762000.0 67410000.0 145210000.0 True False 67907226.5405393 55380158.82326599 116509179.85219614 1.0 0.8155267361744646 1.7157110632789931 26.01706177534486 -6.8533034208798105 1.2190402867181689 0.9012079181346512 1.754058197128544 0.9449795251605311 0.09106836585943286 0.15385684017899023 0.43832261264398154 0.058403363161600275 0.13546600335129116 1.401833967695477e-07 6.8533034208798105 0.8528502789938929 LK(ub)SEDGVEGDLGETQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKSEDGVEGDLGETQSR 17 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 64481000.0 15696000.0 19899000.0 28886000.0 True False 21499235.368450932 19019796.38280667 22063721.725844145 1.0 0.88467315496798 1.026256113192824 24.35778201473509 -6.690041783618992 1.8657289173046836 0.9277047489306343 1.0257750524220324 0.3709455198604449 0.048773991179093965 0.4165334963073671 2.81105706314264 0.020910570347647827 0.05446053197444607 2.0415415178206105e-07 6.690041783618992 0.09807030349139811 LK(ub)SEDGVEGDLGETQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKSEDGVEGDLGETQSR 17 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 102369000.0 21411000.0 42249000.0 38709000.0 True False 17804195.168126762 42021396.25123013 46802872.92980592 1.0 2.3601963388076777 2.628755329170558 24.085713884905715 -10.361535501981855 0.35053306644966215 1.2553112030345752e-24 2.6797673634782053 0.9990668079745302 0.021780338586623867 1.8152074433959178 0.16458277388351997 1.7559885348911404 0.07945297170105926 4.349752015491137e-11 10.361535501981855 2.6797673634782053 LK(ub)SEDGVEGDLGETQSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKSEDGVEGDLGETQSR 17 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 193572000.0 44762000.0 47010000.0 101800000.0 True False 57945291.39093191 44393852.174888864 83273444.55620782 1.0 0.7661339016380585 1.437104595684881 25.78818809743731 -6.812560659753664 1.4038357755275117 0.8729272213578698 1.4495329020970693 0.8663895727712302 0.10164584758829191 0.20332740806475746 0.7892762453629925 0.05692648748236608 0.13153077790418918 1.539711453005765e-07 6.812560659753664 0.5766056807391995 LK(ub)SEGETIMSSSMGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKSEGETIMSSSMGK 15 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 16914900.0 5960100.0 5279100.0 5675700.0 True False 7813748.817690499 4491478.857770624 5088433.009158786 1.0 0.5748174099993868 0.6512153292717142 22.897583448432044 -10.780565621758058 7.088884926716305 1.0107683097165092 0.6130163696355505 0.9715994715974859 0.03118931993792388 0.005292292940128357 0.0001638211587812425 0.030109405538638077 0.010066309724926174 1.6574268812529805e-11 10.780565621758058 -0.3977519400809587 LK(ub)SEGETIMSSSMGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKSEGETIMSSSMGK 15 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 20031200.0 7903000.0 4811500.0 7316700.0 True False 7652123.590883496 6732757.041641031 5400236.773704998 1.0 0.8798547176710829 0.7057174011327618 22.867428744434598 -6.965821327991339 0.34366424894929215 1.0181036911680617 0.561649058702883 0.9999290867097653 0.0010173460362807734 0.07768332711590173 0.013883303221923764 0.0024316402134073136 0.01503265184937384 1.081878952872451e-07 6.965821327991339 -0.4564546324651787 LK(ub)SEGETIMSSSMGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKSEGETIMSSSMGK 15 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 13236500.0 5960100.0 2849700.0 4426700.0 True False 8163710.035646299 2723790.8313022824 3381204.6307482566 1.0 0.33364620000086115 0.4141750032747918 22.960793509954936 -10.594999556205291 6.485486682373566 1.001479147096277 0.37391060164069007 0.9877443703006819 0.03287574626968292 0.0007044394104818102 4.399023825226204e-05 0.03189139659622973 0.01061060148305188 2.5409753021073204e-11 10.594999556205291 -0.6275685454555868 LK(ub)SEGETIMSSSMGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKSEGETIMSSSMGK 15 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 20622800.0 7903000.0 7657800.0 5062000.0 True False 6571694.662262665 7616545.911445712 6120440.795956436 1.0 1.1589926651922837 0.9313337138291722 22.647834019868874 -6.7189521674552335 1.763250602793519 1.0968376720142379 0.9317131295199812 0.5075111832487027 0.06691335995367288 0.3573482760355619 2.1707517211730223 0.030139724635530482 0.07575069186649787 1.9100636185321795e-07 6.7189521674552335 -0.16512454249425668 LK(ub)SEVVSPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKSEVVSPR 9 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 18417900.0 6547200.0 6230800.0 5639900.0 True False 8583442.603174997 5301188.92746817 5056337.249740931 1.0 0.617606381559221 0.589080335653506 23.033124961850927 -13.999999999999998 0.3682582448127968 6.268488588692465 0.586041833326321 0.9997879041374893 0.0027284391649642754 22.6179998777993 0.19682114315383914 93.99846927182664 0.008016315144899245 1.0000000000000041e-14 13.999999999999998 -5.682446755366144 LK(ub)SEVVSPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKSEVVSPR 9 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 24590900.0 4713300.0 7327600.0 12550000.0 True False 4563678.871429977 10253548.892929185 9262778.508070268 1.0 2.246772654649198 2.0296735964614183 22.12176584760829 -10.050129208409746 4.422702435659096 0.999929873747601 2.138223125667836 0.9734397942909624 0.08863031976902448 30937517.745708685 41406870.26019322 28786.599781455057 0.03243537761176999 8.909858185144374e-11 10.050129208409746 1.1382932519202351 LK(ub)SEVVSPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKSEVVSPR 9 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 62488000.0 17370000.0 10462000.0 34656000.0 True False 26351559.917098626 8594974.360020908 27806226.409735583 1.0 0.32616567622791554 1.0552022915232837 24.65138503093364 -12.015210612382097 18.568103954846183 0.9298705395984962 0.7216155854892503 0.0 0.3391944395278945 0.0 0.0 0.0 0.09869015024617088 9.655825033633962e-13 12.015210612382097 -0.20825495410924588 LK(ub)SEVVSPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKSEVVSPR 9 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 19677000.0 6547200.0 5456400.0 7673400.0 True False 8967876.771427244 5215318.206098115 5861100.958633679 1.0 0.581555516319622 0.6535661793779176 23.09633502337382 -10.72765248444385 6.878116320362528 1.0051206424289816 0.617560847848799 0.9740980256211393 0.029398230088718443 0.0023240538348629847 9.202366291022911e-05 0.028657347999185605 0.009488237961798358 1.872179629597624e-11 10.72765248444385 -0.3875597945801825 LK(ub)SEVVSPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKSEVVSPR 9 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 52408000.0 17370000.0 13671000.0 21367000.0 True False 22485807.41388875 12910196.83222516 17478425.24393412 1.0 0.5741486883077613 0.7773092120827411 24.42251135302609 -10.12553148322359 5.270371303115107 1.000007982416801 0.6757289501950137 0.7725644788762669 0.08293993652170926 7.77948187277784e-06 1.2908627905430528e-06 0.08030822435817934 0.026768749406886894 7.489770610974141e-11 10.12553148322359 -0.3242790322217872 LK(ub)SFQNWPDYAHLTPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKSFQNWPDYAHLTPR 16 1 P98170 P98170 XIAP E3 ubiquitin-protein ligase XIAP 1 6428800.0 2049900.0 3037500.0 1341400.0 True False 1704582.6759676374 3021136.38460346 1621880.538067158 1.0 1.7723613100129958 0.951482471888005 20.7009871443467 -6.659890746699841 1.9730788437798266 1.4971965158120466 0.95489056150271 0.235235018384636 0.32886090629842774 0.4846936580224056 3.6271771792775453 0.13465800283684565 0.36459990286321786 2.1883120574789135e-07 6.659890746699841 -0.5423059543093366 LK(ub)SQEIIPFPSTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKSQEIIPFPSTK 13 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 33433000.0 10228000.0 11178000.0 12027000.0 True False 13409007.048092898 9510285.971502727 10782561.411130374 1.0 0.709246101325253 0.8041282529315942 23.67669907223461 -10.621689372014117 9.362192537580839 1.000069879221682 0.7566871771284236 0.8976247138805656 0.03873547618882186 5.6514569495377635e-05 2.2836203497471835e-06 0.03751615030630296 0.012501821182226746 2.3895197695752256e-11 10.621689372014117 -0.2433827020932584 LK(ub)SQEIIPFPSTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKSQEIIPFPSTK 13 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 54016000.0 10020000.0 13039000.0 30957000.0 True False 15201072.560122529 10712088.57582802 24838335.381064903 1.0 0.7046929440972075 1.6339857127071493 23.857669785418455 -6.821234147124464 1.3664906848814091 0.8410257316762384 1.65482094830605 0.8872042096043544 0.1302058873993017 0.19188366199041074 0.7037033029035932 0.07487014967481387 0.17251242743603076 1.5092662234277374e-07 6.821234147124464 0.8137952166298117 LK(ub)SQEIIPFPSTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKSQEIIPFPSTK 13 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 38448000.0 10228000.0 13278000.0 14942000.0 True False 14009568.001307094 12691334.05552576 11413007.340149669 1.0 0.9059047398422033 0.8146580493477624 23.7399091337575 -6.971502299603005 0.21938772009019958 1.0424056377496658 0.6755825286789952 0.9999918374206856 0.000216109561285343 0.07581839823243088 0.007261671251236825 0.002539349480402213 0.009260334730760779 1.0678191383880499e-07 6.971502299603005 -0.3668231090706706 LK(ub)SQEIIPFPSTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKSQEIIPFPSTK 13 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 53671000.0 16052000.0 24332000.0 13287000.0 True False 13347949.224173116 24200918.686476145 16065250.267853247 1.0 1.8130814164806919 1.2035744216616515 23.670114767818262 -10.462485624951428 5.521144562464022 0.9994524177166243 1.508327919071173 0.4811675930886752 0.2488301886606451 0.001678919129458257 0.0001634514204581346 0.2411765438630019 0.08030959805969334 3.4475801779626845e-11 10.462485624951428 0.5088755013545486 LK(ub)SQEIIPFPSTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKSQEIIPFPSTK 13 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 39617000.0 10020000.0 15712000.0 13885000.0 True False 12971087.523728576 14837613.388041971 11358072.472131101 1.0 1.1438989491743756 0.8756453498099742 23.628796107510905 -6.760988689118924 1.608657179863462 1.08348209722184 0.8746142666066519 0.6950125879035429 0.06053335866445276 0.28126673733374935 1.4347380954674283 0.029686391968030797 0.07127419796504739 1.733849153994943e-07 6.760988689118924 -0.2088678306151881 LK(ub)SVAHLPWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKSVAHLPWR 10 1 O96005-3;O96005-4;O96005;K7ERL5 O96005-3 CLPTM1 Cleft lip and palate transmembrane protein 1 1 4429200.0 1357200.0 1693600.0 1378400.0 True False 1314116.4288937214 2369863.312007328 1017355.6888863789 1.0 1.8033891517529985 0.774174697551595 20.325661671427607 -6.6983909039085345 1.8362637839869291 1.4996389975779698 0.7772892522574353 0.41013994199913717 0.3392189262583246 0.3988575737885079 2.613449007515239 0.14742859137944123 0.3799508293381681 2.002668634844161e-07 6.6983909039085345 -0.7223497453205345 LK(ub)SVAHLPWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKSVAHLPWR 10 1 O96005-3;O96005-4;O96005;K7ERL5 O96005-3 CLPTM1 Cleft lip and palate transmembrane protein 1 1 15906200.0 1357200.0 3576000.0 10973000.0 True False 1128571.9341544842 3556735.378219576 13267403.566580389 1.0 3.1515362650624925 11.755921944417487 20.106066946861883 -6.944879293836106 0.6124895955947832 0.9051425201470362 14.452324237564596 0.998735670760265 0.16523652184654455 0.08560946863321162 0.04499086158144432 0.16756563974698102 0.7261850824877245 1.1353263201238605e-07 6.944879293836106 13.54718171741756 LK(ub)SVGIPVLCLNSVDDVFSPSHAIPIETAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKSVGIPVLCLNSVDDVFSPSHAIPIETAK 30 1 J3KTE1;Q8WU67;J3KSP1 J3KTE1 ABHD3 Phospholipase ABHD3 1 27568500.0 9052200.0 6668300.0 11848000.0 True False 8764842.865923764 9330986.964725116 8744653.367618863 1.0 1.0645926124930802 0.9976965361942317 23.063296796237726 -6.654178928502306 1.9938515899674165 1.0417760254448523 0.9979789948489612 0.2110417600859743 0.027540953925347278 0.498396403631236 3.802505285221699 0.011184788798545342 0.0305089243783473 2.2172827153203083e-07 6.654178928502306 -0.04379703059589102 LK(ub)SVGIPVLCLNSVDDVFSPSHAIPIETAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKSVGIPVLCLNSVDDVFSPSHAIPIETAK 30 1 J3KTE1;Q8WU67;J3KSP1 J3KTE1 ABHD3 Phospholipase ABHD3 1 235582000.0 14269000.0 38256000.0 183057000.0 True False 21647116.20363159 31428917.904507697 146875703.7132668 1.0 1.451875511216366 6.7850009364585215 24.367671508293743 -6.923633537869597 0.7973011442750996 0.8970145397939718 7.721290699157196 0.9951324422649558 0.1832839114226112 0.09608074347373617 0.09487527625396934 0.16103689159683576 0.5005053096082047 1.192247614441242e-07 6.923633537869597 6.824276159363224 up LK(ub)SVGIPVLCLNSVDDVFSPSHAIPIETAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKSVGIPVLCLNSVDDVFSPSHAIPIETAK 30 1 J3KTE1;Q8WU67;J3KSP1 J3KTE1 ABHD3 Phospholipase ABHD3 1 30688200.0 9052200.0 4427000.0 17209000.0 True False 7527305.380454768 4403150.872309304 20807322.334574126 1.0 0.5849571194151929 2.7642458068197886 22.843702071672002 -6.857408781782026 1.1988710403047476 0.7762042714445841 2.8646114624006827 0.9503961944844049 0.21042894726172492 0.14949930007063422 0.40980307836189056 0.13704032063621555 0.31899393772629137 1.3886449471037586e-07 6.857408781782026 2.0884071909560986 up LK(ub)SVGIPVLCLNSVDDVFSPSHAIPIETAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKSVGIPVLCLNSVDDVFSPSHAIPIETAK 30 1 J3KTE1;Q8WU67;J3KSP1 J3KTE1 ABHD3 Phospholipase ABHD3 1 133560000.0 14269000.0 39062000.0 80229000.0 True False 18471501.784040235 36888165.361742325 65628145.21905699 1.0 1.9970311993589214 3.5529404152596347 24.138797830386192 -6.964591264878537 0.3649988845198281 0.873355646963565 4.730352126682834 0.9999044708631912 0.01026772783035825 0.07809993127947808 0.015350644655043157 0.020677547461459035 0.13250773293308285 1.0849475292149235e-07 6.964591264878537 3.856996479719269 LK(ub)SYCNDQSTGDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKSYCNDQSTGDIK 14 1 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 1 59134300.0 2754500.0 11205000.0 45174800.0 True False 4178777.880923901 9205380.204935422 36245980.97918178 1.0 2.2028881331448447 8.673823307202925 21.994649644900974 -6.938187370720241 0.6762168396894956 0.9245844685496788 10.329548648550373 0.9979167048714144 0.15381388433726514 0.0886034251414599 0.05844903276803335 0.1477446222230738 0.5615338753003879 1.1529557227116705e-07 6.938187370720241 9.404964180000695 LK(ub)SYCNDQSTGDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKSYCNDQSTGDIK 14 1 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 1 56899500.0 2754500.0 7200000.0 46945000.0 True False 3565754.5493124095 6799313.6706913365 38401491.69637698 1.0 1.9068372701094807 10.769527505414528 21.765775966993424 -6.926573654313816 0.7744061883034323 0.8467306098013759 12.439762991573124 0.9958208012969659 0.2849131476171891 0.09445643165165744 0.08668686013050603 0.254461626892115 0.8175491355221447 1.1842035145858782e-07 6.926573654313816 11.593032381771748 up LK(ub)TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK 37 1 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 83655900.0 33070500.0 36979500.0 13605900.0 True False 43355745.7551776 31462302.744962 12198091.985008616 1.0 0.7256778126392792 0.281348914026047 25.36971986465285 -7.047795105337472 0.39384079317554255 1.027667887379689 4.0333239013675176e-11 0.9998664065175928 0.0034225346293523602 0.07324743261779731 0.01760149071972953 0.005947005366245304 0.035080744780921144 8.957872870227343e-08 7.047795105337472 -1.0276678873393557 down LK(ub)TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK 37 1 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 59489200.0 9310500.0 38520000.0 11658700.0 True False 9014943.27381004 53901236.87914632 8604936.716497123 1.0 5.979098840892175 0.9545192304754644 23.103886982906314 -6.648247841930354 2.014603730283078 4.235387153869685 0.975549409168776 0.1870342333070364 2.1260479981676874 0.5128480919640894 3.987594678725223 0.856426120561738 2.3549589954636985 2.247771487956385e-07 6.648247841930354 -3.259837744700909 LK(ub)TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK 37 1 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 52121300.0 20335000.0 28626400.0 3159900.0 True False 30849681.687633865 23517795.26091596 2535344.3799666273 1.0 0.7623351028073363 0.08218381005152878 24.87875226768538 -7.23525951046351 0.6815257256851861 0.9968129977693345 8.889713827273151e-21 0.995774041903277 0.025284040226834874 0.09236587463100275 0.07842760013884365 0.023062011156701846 0.05924415168640638 5.817554888495824e-08 7.23525951046351 -0.9968129977693345 down LK(ub)TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK 37 1 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 72584300.0 33070500.0 30577900.0 8935900.0 True False 45297557.54665884 29226867.270406757 6825424.460637361 1.0 0.6452194964441861 0.1506797458915267 25.432929926175742 -7.455306058509171 0.46928364008859824 1.018862958184743 1.0662875083691372e-25 0.9980689014555538 0.015305560159537298 0.11439143875933187 0.05811649385470988 0.01887226789416071 0.0653928979326474 3.5050477714931213e-08 7.455306058509171 -1.018862958184743 down LK(ub)TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK 37 1 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 65704950.0 9310500.0 55428000.0 966450.0 True False 7742093.275084968 55129398.36240335 1168530.226640083 1.0 7.120735491500303 0.15093207807254924 22.88429225834059 -6.674766630993068 1.9204136677238206 4.890741446165581 0.1784493020325331 0.30031621044447676 2.5971415919609075 0.45029310933466427 3.205981893552634 1.0869909308541923 2.886302222926761 2.1146250325784913e-07 6.674766630993068 -4.712292144133048 LK(ub)TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK 37 1 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 80119300.0 20335000.0 54078000.0 5706300.0 True False 26324058.362776477 51068511.761617444 4667811.951582403 1.0 1.9399938663648784 0.17732113670523236 24.649878589777828 -6.761834653990053 1.6053977009508114 1.5447707307252494 0.17026282011824231 0.6984126270071507 0.3954786341887236 0.2798797607478078 1.4220516783115127 0.19432046259334007 0.4661717317362089 1.7304750659191132e-07 6.761834653990053 -1.374507910607007 LK(ub)TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIR 47 2 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 29199400.0 13372000.0 12035000.0 3792400.0 True False 12947513.17946273 16840638.2616959 2799056.6704387055 1.0 1.300685160792763 0.21618488675327652 23.626171691221394 -6.832741784446992 1.3155970834111133 1.1603855316524945 0.185328903476199 0.9112532066266694 0.13618838624472454 0.17744987250323424 0.5996864855201193 0.0812541790657962 0.18699076623964253 1.4697999069624078e-07 6.832741784446992 -0.9750566281762955 down LK(ub)TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIR 47 2 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 73090600.0 33050000.0 31713000.0 8327600.0 True False 50139266.27864768 26053567.375200037 6681646.20988325 1.0 0.5196240254176837 0.1332617468462776 25.5794375486183 -8.00380519605422 0.3811535904220205 1.0703205892489862 9.722264828410599e-23 0.9978919040157609 0.01627823988495162 0.098212299707641 0.08139873244246855 0.04873374893781971 0.08345237709202072 9.912764848912037e-09 8.00380519605422 -1.0703205892489862 down LK(ub)TEGNEQMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKTEGNEQMK 10 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 5459420.0 909090.0 1226530.0 3323800.0 True False 1191825.7936400834 1043536.5049764942 2979885.060140947 1.0 0.8755780505381723 2.5002689789417625 20.18474194520935 -6.8884212759069285 1.0317066419693985 0.9093705170833364 2.635745238645961 0.979867320805411 0.10475849504532317 0.12043217878016552 0.2294197733156522 0.07752490762620802 0.19219903271972455 1.292941049597823e-07 6.8884212759069285 1.7263747215626248 up LK(ub)TEGNEQMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKTEGNEQMK 10 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 8191610.0 1037510.0 1533200.0 5620900.0 True False 1004574.8129542605 2145414.755532376 4148617.6666145143 1.0 2.13564458103735 4.129724947427491 19.938153578152995 -6.96250819773431 0.3985113792258031 0.8885667858151141 5.449439481140648 0.9998522122541548 0.01572635421253597 0.07881701097408711 0.01790777133481334 0.025663903179225202 0.16716496702030623 1.0901639142777764e-07 6.96250819773431 4.560872695325534 LK(ub)TEGNEQMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKTEGNEQMK 10 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 6078630.0 313930.0 3258900.0 2505800.0 True False 476254.76135721133 2677323.8330980814 2010527.5316688428 1.0 5.621621137116517 4.221537913740376 18.861373990459253 -9.547464940765506 7.138187141580628 1.0000158907325831 4.921579525432425 0.9127438898567506 0.5715815825384739 0.0 0.0 0.5534314875029139 0.18447716250097126 2.83488247544379e-10 9.547464940765506 3.921563634699842 LK(ub)TEGNEQMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKTEGNEQMK 10 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 4765070.0 909090.0 456280.0 3399700.0 True False 1245205.1402335027 436120.0408838147 2596760.8790193303 1.0 0.35023951218353694 2.085408094711512 20.24795200673224 -6.805285007200819 1.434251007070523 0.6438600760518358 2.1125989749897625 0.8471515067866608 0.27984144889572965 0.2133072472049995 0.8656436835992611 0.15345706658956115 0.3557970854043657 1.5657232217993003e-07 6.805285007200819 1.4687388989379266 up LK(ub)TEGNEQMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKTEGNEQMK 10 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 5898670.0 1037510.0 1867960.0 2993200.0 True False 862735.5344861601 1857896.9287189688 3619064.2810068727 1.0 2.1534953116606244 4.194871007790776 19.718558853587272 -6.962364518124155 0.40071860330084097 0.8886685549774292 5.534322912508112 0.9998480935410589 0.016281160254642366 0.07886702904378524 0.018087911807244204 0.02626428431935839 0.17098825093519474 1.0905246378089654e-07 6.962364518124155 4.645654357530683 LK(ub)TEGNEQMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKTEGNEQMK 10 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 3750450.0 313930.0 2163020.0 1273500.0 True False 406388.5734854396 2042646.0355526062 1041736.0672134636 1.0 5.02633727625167 2.5633990106535016 18.632500312551702 -9.604777078898712 8.604973256784545 1.0005243293520836 3.7948681434296954 0.6319384173164537 1.0054903820185181 0.0 2.8493073255570134e-17 0.9735618409920335 0.32452061849721103 2.4844080117914443e-10 9.604777078898712 2.794343814077612 LK(ub)TEGSDLCDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKTEGSDLCDR 11 1 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 1 49733800.0 21977800.0 18633100.0 9122900.0 True False 28813108.633317985 15853114.111254921 8178949.821036119 1.0 0.5502049193304746 0.28386211030275316 24.78022198482494 -8.75489482989156 0.20321789063449683 1.349092232367907 2.9659260522048335e-19 0.9996237942601013 0.0057323437637461835 0.29470898765053033 0.05951033247622716 0.1989921780614511 0.13202013371838836 1.758349369781765e-09 8.75489482989156 -1.349092232367907 down LK(ub)TEGSDLCDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKTEGSDLCDR 11 1 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 1 28198700.0 10816300.0 9941000.0 7441400.0 True False 10472942.477043288 13910493.14163014 5492274.102785192 1.0 1.3282315998700431 0.5244251188072759 23.320163502911143 -6.795844572700981 1.4729238671661473 1.182064092152247 0.5144476436428385 0.8197049826888355 0.14011556187257534 0.22674362940957007 0.9715636432773798 0.07485408895399677 0.17453401671154514 1.6001305882197667e-07 6.795844572700981 -0.6676164485094085 LK(ub)TEGSDLCDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKTEGSDLCDR 11 1 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 1 47608600.0 7578600.0 11850900.0 28179100.0 True False 11497290.2698747 9736014.303495683 22609488.533661738 1.0 0.846809472055 1.9665058464169873 23.454790544958612 -6.872336848338949 1.1215914680866408 0.9119970306939977 2.0350800138650174 0.9669636776698488 0.0900949550990192 0.1346374586605549 0.31511846401306937 0.06224540293804036 0.14800426712488363 1.3417238869338993e-07 6.872336848338949 1.1230829831710196 LK(ub)TEGSDLCDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKTEGSDLCDR 11 1 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 1 43256800.0 21977800.0 10982000.0 10297000.0 True False 30103586.587712876 10496778.927382428 7865060.673371769 1.0 0.34868864866975047 0.2612665653793553 24.843432046347832 -13.999999999999998 0.28301860462797435 6.397451655759137 0.23572241343678932 0.9996118760459937 0.006492905822388201 15.563969659105929 0.16857326684643942 48.71038786678069 0.03409357250105398 1.0000000000000041e-14 13.999999999999998 -6.161729242322347 LK(ub)TEGSDLCDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKTEGSDLCDR 11 1 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 1 33949700.0 10816300.0 10374900.0 12758500.0 True False 8994232.693335645 10319008.354443578 15426243.36136114 1.0 1.147291681934084 1.7151261132916151 23.10056877834542 -6.945723369978839 0.6039832471235432 0.99365605866476 1.8980284177492988 0.9988214089717344 0.010584721263501781 0.0852500255028777 0.043431060105029 0.010821328394787163 0.04778218238417816 1.1331218914545207e-07 6.945723369978839 0.9043723590845387 LK(ub)TEGSDLCDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKTEGSDLCDR 11 1 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 1 37290600.0 7578600.0 12461400.0 17250600.0 True False 9810647.09653985 11767912.135549035 14111167.806103306 1.0 1.1995041733485143 1.4383524009420563 23.225916867051062 -6.96873296051573 0.28683718590410867 0.9515295230029751 1.6936741116591196 0.9999707437418871 0.0009692409838137031 0.07671599058385045 0.010494417515629522 0.0042451768896448056 0.021740344152650942 1.0746499912387956e-07 6.96873296051573 0.7421445886561445 LK(ub)TEPEEVSIEDSAQSDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKTEPEEVSIEDSAQSDLK 19 1 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 17702500.0 4639200.0 4418000.0 8645300.0 True False 6082036.126076707 3758851.6212291145 7750767.287573409 1.0 0.6180252046042694 1.274370478389963 22.53612295503799 -6.748937164468374 1.6537493020559422 0.7751086659432654 1.2755721516464238 0.6443959699635764 0.16050068672694115 0.30190312366356337 1.6241723553529925 0.07667782539436477 0.1863633460628402 1.782636668076684e-07 6.748937164468374 0.5004634857031584 LK(ub)TEPEEVSIEDSAQSDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKTEPEEVSIEDSAQSDLK 19 1 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 20934600.0 4280900.0 6378700.0 10275000.0 True False 4145005.172746186 8925748.174481064 7583669.256607342 1.0 2.1533744356143942 1.829592229816915 21.982942471453068 -10.089054367083953 4.794268458715928 0.9999574444552994 1.991483332727006 0.9259407071496916 0.1321835320385004 91911446.35904537 2.835904562180685 43179.254628245326 0.045249938886733856 8.1460230178124e-11 10.089054367083953 0.9915258882717066 LK(ub)TEPEEVSIEDSAQSDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKTEPEEVSIEDSAQSDLK 19 1 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 60893000.0 10072000.0 16126000.0 34695000.0 True False 15279960.36183174 13248189.306986922 27837518.042641286 1.0 0.8670303451885885 1.8218318230836146 23.8651374650549 -6.87166458316442 1.1251946431494875 0.9239769320373263 1.8795617686927095 0.9663193452013891 0.07749444635928404 0.135271793252025 0.3190648466707352 0.0533923977832951 0.12679259872700394 1.343802413742274e-07 6.87166458316442 0.9555848366553832 LK(ub)TEPEEVSIEDSAQSDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKTEPEEVSIEDSAQSDLK 19 1 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 17809800.0 4639200.0 4282900.0 8887700.0 True False 6354437.609666 4093667.3163436702 6788608.3079272 1.0 0.6442218128189066 1.068325589915426 22.59933301656088 -6.684144868315551 1.8867360188029703 0.7757492050141259 1.066786212807637 0.34344750500681565 0.15065058432222192 0.42934317912452913 2.958274300424775 0.06398141734093117 0.1678821244580573 2.069450923539297e-07 6.684144868315551 0.29103700779351116 LK(ub)TEPEEVSIEDSAQSDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKTEPEEVSIEDSAQSDLK 19 1 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 19022700.0 4280900.0 8765600.0 5976200.0 True False 3559758.0260255854 8718377.972964626 7225795.789173229 1.0 2.4491490458688734 2.0298558880533566 21.763347746887344 -10.326868161731515 5.40327896708617 0.9997141565192512 2.2395024669611536 0.9209606938680678 0.17117571488151487 0.0005895548133629815 7.344562093282551e-05 0.16577626488813274 0.05524672441758509 4.711203221371115e-11 10.326868161731515 1.2397883104419023 LK(ub)TEPEEVSIEDSAQSDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKTEPEEVSIEDSAQSDLK 19 1 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 74243000.0 10072000.0 10969000.0 53202000.0 True False 13038402.54880181 10358565.50747407 43519781.898618504 1.0 0.7944658456971779 3.337815482819085 23.63626378714735 -6.887322341064988 1.0380527085072648 0.8544431941802664 3.5454582038525855 0.9791298543421519 0.16664871306655818 0.12134423200634423 0.2347335443077491 0.12272818894284293 0.30316875616083605 1.2962168387399357e-07 6.887322341064988 2.691015009672319 up LK(ub)TLLVNNNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKTLLVNNNR 10 1 P09661;H0YKK0 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 1 3440780.0 615080.0 1466700.0 1359000.0 True False 806375.836443193 1247874.0771518212 1218383.7164485052 1.0 1.5475092639878856 1.5109377803563897 19.62109288266219 -10.18481354521145 4.946808403433526 0.9999509036156685 1.529223522173093 0.9964312547250286 0.014930245675648568 8.085411061012558e-06 1.3323604240640498e-06 0.014457484647805873 0.004818716070900627 6.534110200942017e-11 10.18481354521145 0.5292726185574245 LK(ub)TLLVNNNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKTLLVNNNR 10 1 P09661;H0YKK0 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 1 4789000.0 1189200.0 1308400.0 2291400.0 True False 1151449.4969351694 1830850.9432158633 1691213.599473484 1.0 1.5900401607617762 1.4687692373612675 20.135019704624273 -10.118685942179953 4.607496624653268 0.9999602865810715 1.529404699003912 0.9621352424319272 0.04950864733335841 34526055.498954676 1.671521924191968 16863.90346080943 0.016948126807911256 7.608763018251679e-11 10.118685942179953 0.5294444124228406 LK(ub)TLLVNNNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKTLLVNNNR 10 1 P09661;H0YKK0 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 1 2609100.0 615080.0 460620.0 1533400.0 True False 842491.6979120028 440268.28533335426 1171242.5013643077 1.0 0.5225787819921517 1.390212513983304 19.68430294418508 -6.7573143222622045 1.6225446593268709 0.7217623844679946 1.3929717166576525 0.6799153858680935 0.2007350670311965 0.2874564280114445 1.4908827922577395 0.0976419284162422 0.2352786996693237 1.7485806887038427e-07 6.7573143222622045 0.671209332189658 LK(ub)TLLVNNNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKTLLVNNNR 10 1 P09661;H0YKK0 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 1 3767000.0 1189200.0 1577700.0 1000100.0 True False 988872.4904925665 1569200.6169510703 1209216.2860600608 1.0 1.5868583988714633 1.222823263551137 19.91542498005855 -10.16513724094256 4.424934538518407 0.9999322317718454 1.4048408312263259 0.6224991045279236 0.1486167219293274 104117255.7360412 13.518933323922665 86836.31666001512 0.05087545684746979 6.83695559225592e-11 10.16513724094256 0.40490859945448043 LK(ub)TNHIGHTGYLNTVTVSPDGSLCASGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKTNHIGHTGYLNTVTVSPDGSLCASGGK 29 1 P63244;J3KPE3;D6RAC2;H0Y8W2;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 9396400.0 2944600.0 2359000.0 4092800.0 True False 2851125.284792552 3300961.002022489 3020772.898631876 1.0 1.1577747984731817 1.0595019849686007 21.443100005224952 -10.295820315333378 5.818683775307918 0.9999913189814881 1.1086383917208895 0.6196910095433465 0.04011970811232111 4.518626867555147e-06 5.468332066175877e-07 0.038848843847625526 0.012948580114476589 5.060339848112591e-11 10.295820315333378 0.10864707273940144 LK(ub)TNHIGHTGYLNTVTVSPDGSLCASGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKTNHIGHTGYLNTVTVSPDGSLCASGGK 29 1 P63244;J3KPE3;D6RAC2;H0Y8W2;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 532069700.0 19972700.0 61797000.0 450300000.0 True False 30300046.099956006 50768842.527835265 361298007.6264986 1.0 1.675536808107661 11.92400851254887 24.852816652897463 -6.920286662218991 0.822589947971129 0.7762005613509301 13.587656363024639 0.9942603011676537 0.3786536984676978 0.09800363723826178 0.1047400105651785 0.32674439448985926 0.981464874276542 1.2014711248091757e-07 6.920286662218991 12.81145580167371 up LK(ub)TNHIGHTGYLNTVTVSPDGSLCASGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKTNHIGHTGYLNTVTVSPDGSLCASGGK 29 1 P63244;J3KPE3;D6RAC2;H0Y8W2;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 18697600.0 3500000.0 5691000.0 9506600.0 True False 4794044.583943573 5439552.80237965 7261336.8745728005 1.0 1.1346479381101382 1.514657769118959 22.192811895235543 -6.952815209829716 0.5270324900590392 0.9938760932304654 1.6725932025348327 0.9994040910176711 0.005319745739514775 0.08237462010877024 0.03143352790635433 0.005961291286230689 0.03141315176722783 1.1147687613298118e-07 6.952815209829716 0.6787171093043672 LK(ub)TNHIGHTGYLNTVTVSPDGSLCASGGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKTNHIGHTGYLNTVTVSPDGSLCASGGK 29 1 P63244;J3KPE3;D6RAC2;H0Y8W2;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 510772700.0 19972700.0 41350000.0 449450000.0 True False 25855053.870775815 39048836.15042874 367654711.74644005 1.0 1.5102979999808073 14.219839323638125 24.623942974989912 -6.915358717516544 0.8584530750852861 0.6699927968253021 16.06543145480214 0.9927913645108839 0.5191998874782925 0.10097987659774132 0.12033782187548696 0.43667790817234153 1.2552372408073114 1.215181872995436e-07 6.915358717516544 15.39543865797684 up LK(ub)TPPRPQGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKTPPRPQGQR 11 2 Q99942 Q99942 RNF5 E3 ubiquitin-protein ligase RNF5 1 11795000.0 4397700.0 4692100.0 2705200.0 True False 6023648.533373889 4484787.507300227 2066287.475342849 1.0 0.7445300771537986 0.34302922288620097 22.522206163711317 -6.964470793519949 0.36702617576700525 1.0319356465217147 0.04171316227489223 0.9999018108850425 0.002679465900483741 0.07814106011717348 0.015496281820771026 0.0053172375517359935 0.03415460363282698 1.0852485305825957e-07 6.964470793519949 -0.9902224842468225 down LK(ub)TPPRPQGQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKTPPRPQGQR 11 2 Q99942 Q99942 RNF5 E3 ubiquitin-protein ligase RNF5 1 14187100.0 4072400.0 8557700.0 1557000.0 True False 3386381.0379094617 8511597.971529542 1882561.5012453892 1.0 2.5134791023942378 0.5559213449906287 21.691312884723615 -6.700269887773704 1.8299991331055196 1.9395622959030825 0.5617313236283262 0.41883287626386045 0.638826462450366 0.394952660748407 2.5716437334097257 0.27847974636654627 0.7159134708078028 1.9940227652172986e-07 6.700269887773704 -1.3778309722747561 LK(ub)VCALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKVCALR 7 1 J3QQ67;Q07020;G3V203;Q07020-2;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 12057100.0 3736800.0 5372900.0 2947400.0 True False 4898980.98722268 4571284.263400169 2642431.321457192 1.0 0.9331092068580801 0.5393838694922622 22.22405026190579 -6.9362426149295295 0.6936441691423261 1.0048352591744456 0.44400252373766996 0.9976290594110723 0.009894928094748822 0.08952360763344112 0.06273517211103 0.009376982281942605 0.03448529949629811 1.1581301957936125e-07 6.9362426149295295 -0.5608327354367757 LK(ub)VCALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKVCALR 7 1 J3QQ67;Q07020;G3V203;Q07020-2;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 12733300.0 5710000.0 5041500.0 1981800.0 True False 5528739.175495978 7054597.241075185 1462707.1272743968 1.0 1.2759866250052072 0.2645643212393319 22.398519081854197 -6.833991781980339 1.309955560292603 1.147111604149679 0.235055037410304 0.9136298388935886 0.12545378515567998 0.17593526090489378 0.5890107822261094 0.07516083242892312 0.17297973395844682 1.4655755733251328e-07 6.833991781980339 -0.912056566739375 down LK(ub)VCALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKVCALR 7 1 J3QQ67;Q07020;G3V203;Q07020-2;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 31181300.0 9224200.0 5239100.0 16718000.0 True False 13993785.77934952 4304141.6717248615 13413679.972240282 1.0 0.30757521514131203 0.9585454703783379 23.738282975980727 -10.894571084082534 10.532659992802248 1.0284542882032393 0.6330603427598345 0.2975794599654936 0.2657574938433404 0.12964911648252767 0.0012977483003002862 0.18787428951411375 0.08577286231542308 1.2747614335503867e-11 10.894571084082534 -0.3953939454434048 LK(ub)VCALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKVCALR 7 1 J3QQ67;Q07020;G3V203;Q07020-2;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 13048300.0 3736800.0 3249800.0 6061700.0 True False 5118395.943222954 3106213.090348517 4630051.304630253 1.0 0.6068723726739662 0.9045902966457106 22.287260323428683 -10.336000055637884 5.821818579104399 1.0000332797876774 0.7557313346598378 0.4730079007734085 0.12154283350191747 5.250841084886337e-05 5.988878723964593e-06 0.11769935212292411 0.03922778083364855 4.613175154605448e-11 10.336000055637884 -0.24430194512783965 LK(ub)VCALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKVCALR 7 1 J3QQ67;Q07020;G3V203;Q07020-2;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 17370000.0 5710000.0 5586700.0 6073300.0 True False 4748117.9958901405 5556603.338226877 7343198.950233554 1.0 1.1702749053491388 1.546549381584378 22.178924357288473 -6.958047934470438 0.4621240234656871 0.9892618370428623 1.742784937219422 0.9996908060535445 0.004015276707418143 0.08040595343485347 0.023764669875393257 0.005128934110507638 0.031077105452002086 1.1014177358354852e-07 6.958047934470438 0.7535231001765597 LK(ub)VCALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKVCALR 7 1 J3QQ67;Q07020;G3V203;Q07020-2;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 1 25372300.0 9224200.0 7612500.0 8535600.0 True False 11940908.736165378 7188857.683074696 6982208.3826519335 1.0 0.6020360629088333 0.5847300684498952 23.509409298073177 LK(ub)VFSSGPDIHYDPHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKVFSSGPDIHYDPHR 16 1 Q6ZU80;H0YJE3;Q6ZU80-1;H0YJD7 Q6ZU80 CEP128 Centrosomal protein of 128 kDa 1 9057200.0 2493900.0 3825900.0 2737400.0 True False 2414732.5095918416 5353601.821804933 2020392.8197602844 1.0 2.217057914505754 0.8366942556721482 21.203431953640358 -6.673884831227965 1.9232853671764827 1.7742083820808812 0.8421252408254745 0.2965444661942712 0.5165168145186279 0.4522342295729745 3.2285531553305598 0.21590762160861254 0.5740110892702603 2.118922969239668e-07 6.673884831227965 -0.9320831412554067 LK(ub)VFSSGPDIHYDPHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKVFSSGPDIHYDPHR 16 1 Q6ZU80;H0YJE3;Q6ZU80-1;H0YJD7 Q6ZU80 CEP128 Centrosomal protein of 128 kDa 1 8266600.0 2493900.0 4064800.0 1707900.0 True False 2073788.3485027 4042902.1156003694 2065013.993562621 1.0 1.9495249447801137 0.9957689245643538 20.983837229074634 -6.647215309680373 2.018867218945483 1.6175021492080597 0.9997963224756691 0.18277454813082505 0.40554664501166965 0.5153195956101371 4.022782102220482 0.16311026479485258 0.4490391086677957 2.2531219075324462e-07 6.647215309680373 -0.6177058267323906 LK(ub)VGLQVVAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKVGLQVVAVK 11 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 3751800.0 1532700.0 2219100.0 0.0 True False 1484045.277457564 3105198.2024536207 0.0 1.0 2.0923877792821677 0.0 20.501103677837484 -6.769621579202907 1.6072096612623445 1.6304780039208373 3.342114125238307e-11 0.7101861930910953 0.460009876453443 0.27140380109896933 1.388622273427983 0.2267868645187821 0.533277278425204 1.699724055299786e-07 6.769621579202907 -1.6304780038874163 LK(ub)VGLQVVAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKVGLQVVAVK 11 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 8575200.0 1971200.0 2649300.0 3954700.0 True False 2990454.5140233035 2176511.7159246234 3173051.811593414 1.0 0.727819702897398 1.0610600484688353 21.511933343143422 -6.6895763291659 1.8677501950990327 0.8292887676256916 1.0599058663135241 0.36841165021554445 0.11512384878716428 0.41764119169170877 2.8243728021512395 0.04931324288725653 0.12849183856877336 2.04373070977175e-07 6.6895763291659 0.23061709868783253 LK(ub)VGLQVVAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKVGLQVVAVK 11 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 3457330.0 1532700.0 1663000.0 261630.0 True False 1274507.9601227357 1654041.0889203448 316335.6233595575 1.0 1.297787962627601 0.24820215585714678 20.28150895327176 -6.830898507381356 1.323782446028385 1.1590289123912318 0.21941679344244283 0.9076692461484673 0.13420025665817292 0.1797135144667301 0.6155866903660511 0.07958625783397383 0.18315718759090627 1.476051439390719e-07 6.830898507381356 -0.939612118948789 down LK(ub)VIAQQVQLQQQQEQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKVIAQQVQLQQQQEQVR 18 1 Q01664 Q01664 TFAP4 Transcription factor AP-4 1 5419020.0 864220.0 3378500.0 1176300.0 True False 718637.2214375089 3360299.349920252 1422258.8914033114 1.0 4.675932792902874 1.9791055194139953 19.454904135344137 -6.566477078056638 2.3194185194582646 3.523073106709525 1.9840104328492212 0.0 1.602338048617498 0.7409008575778475 7.476877911625448 0.5849853037655726 1.7993396652757572 2.713456863878638e-07 6.566477078056638 -1.5390626738603037 LK(ub)VPPAINQFTQALDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKVPPAINQFTQALDR 16 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 22059900.0 2506600.0 7000300.0 12553000.0 True False 3286176.8739489275 5955882.526955687 11254135.976878645 1.0 1.8124047351713704 3.424689664788126 21.6479787027776 -6.960195878523558 0.43266403427536887 0.9377380471824366 4.361457591894971 0.9997773961637668 0.015034344321479787 0.079631219390035 0.020873288475198024 0.0210797675044299 0.13378885160857676 1.0959837664154344e-07 6.960195878523558 3.4237195447125344 LK(ub)VPPAINQFTQALDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKVPPAINQFTQALDR 16 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 84610000.0 17876000.0 31571000.0 35163000.0 True False 17308536.164827675 44177464.94059001 25952755.43261159 1.0 2.5523513091974896 1.4994194301277572 24.044980380999 -10.511236658143751 5.443287149667878 0.9977581502197593 2.0258853696612746 0.5586381841058901 0.429857639605132 0.011711428507249022 0.001051590498429811 0.4167857991181328 0.1387359566192239 3.0815083001546584e-11 10.511236658143751 1.0281272194415152 LK(ub)VPPAINQFTQALDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKVPPAINQFTQALDR 16 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 20862000.0 0.0 5023000.0 15839000.0 True False 0.0 4126606.4051218703 12708414.707519671 0.0 LK(ub)VPPAINQFTQALDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKVPPAINQFTQALDR 16 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 37609100.0 2506600.0 7430500.0 27672000.0 True False 3433357.758317983 7102195.940622399 21136443.522729307 1.0 2.0685860433320515 6.15620189056096 21.71118876430049 -6.945901699095561 0.602159802731785 0.9541687400361484 7.480643224512823 0.9988391506353348 0.07570743673642556 0.0851743653412091 0.04310340710660522 0.07753717726455536 0.34375663975853915 1.1326567067615674e-07 6.945901699095561 6.526474484476675 LK(ub)VPPAINQFTQALDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKVPPAINQFTQALDR 16 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 50527000.0 17876000.0 20829000.0 11822000.0 True False 14864686.041073916 20716790.042767223 14293925.5412479 1.0 1.3936917325749663 0.9616029226416961 23.825385656433276 -6.666931966244779 1.9484255784637519 1.2519511163721302 0.9633764235450675 0.2655029679380404 0.1673506183288814 0.468168592425813 3.423575318850502 0.06922260341149565 0.18567658711988735 2.1531190019570135e-07 6.666931966244779 -0.2885746928270627 LK(ub)VPPAINQFTQALDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKVPPAINQFTQALDR 16 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 13811100.0 0.0 5044600.0 8766500.0 True False 0.0 4763863.575440213 7171086.951885998 0.0 LK(ub)VTEGGEPYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKVTEGGEPYR 11 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 1 15076800.0 2056200.0 3376500.0 9644100.0 True False 2695698.1122691254 2872739.3614939186 8646221.04473954 1.0 1.065675473236047 3.2074144376135334 21.362227509345928 -6.913441276731722 0.8719642276389664 0.9406847783732681 3.5055897448542948 0.9921568737591133 0.09081583380284108 0.10218635321569074 0.1267461616357942 0.07564110868815747 0.21413675803236074 1.2205588478447842e-07 6.913441276731722 2.5649049664810266 up LK(ub)VTEGGEPYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKVTEGGEPYR 11 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 1 40526710.0 2952600.0 4988210.0 32585900.0 True False 2858871.32917153 6980028.266171499 24050675.233954377 1.0 2.4415328507261767 8.412646973140971 21.447014258567926 -6.944072633480711 0.6205183750340487 0.9346710604199334 10.236129604485113 0.998650155928819 0.11789965076171295 0.08595679729222654 0.04651077354466254 0.11867784208540373 0.5054363436189245 1.1374370395190325e-07 6.944072633480711 9.301458544065179 LK(ub)VTEGGEPYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKVTEGGEPYR 11 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 1 82201200.0 7402200.0 49468000.0 25331000.0 True False 11229678.57330728 40640048.90475193 20324316.747028314 1.0 3.6189859433156446 1.8098751993969628 23.42081329833188 -9.291122680972663 8.90179917141582 1.0000236615621003 2.7144305713568495 0.5449218482285967 0.7385663685931985 0.0 0.0 0.715113811349489 0.23837127044982961 5.11537314339889e-10 9.291122680972663 1.7144069097947492 LK(ub)VTEGGEPYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKVTEGGEPYR 11 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 1 20731500.0 2056200.0 3467200.0 15208100.0 True False 2816432.7067156476 3314007.639502851 11616260.000651177 1.0 1.176668496854464 4.124458565245591 21.42543757086882 -6.919178485343055 0.8307973170967219 0.933010687821281 4.590947269567984 0.9939495315490726 0.11147013563044271 0.09865803096221658 0.10813738884918644 0.0956269195259955 0.2842365582954349 1.2045407992373204e-07 6.919178485343055 3.6579365817467027 up LK(ub)VTEGGEPYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKVTEGGEPYR 11 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 1 33451300.0 2952600.0 7775800.0 22722900.0 True False 2455217.722358185 7733910.222024551 27474153.33118105 1.0 3.149989571839801 11.190108755321587 21.227419534002202 -6.946422596442302 0.5968284212705327 0.9087710531829309 13.840667944321064 0.998889798899507 0.14612801497191014 0.08495485809899948 0.04215836978688054 0.15045013943494923 0.6749821167813707 1.1312990008396727e-07 6.946422596442302 12.931896891138132 LK(ub)VTEGGEPYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKVTEGGEPYR 11 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 1 157838800.0 7402200.0 35405600.0 115031000.0 True False 9582293.819176009 33435247.235976275 94096538.31773217 1.0 3.489273848926019 9.81983438343614 23.19193962042433 -6.955094244706407 0.4998034102022697 0.8730022247778136 12.709055278274652 0.9995427727361205 0.07938969287028097 0.08150243012392758 0.027979033393198887 0.09313807154016998 0.5222101932661622 1.1089341432812142e-07 6.955094244706407 11.836053053496839 LK(ub)VTHQAESNLYMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKVTHQAESNLYMK 14 1 Q16602 Q16602 CALCRL Calcitonin gene-related peptide type 1 receptor 1 6545510.0 960020.0 656090.0 4929400.0 True False 1258595.5168469043 558203.92941879 4419352.974143686 1.0 0.4435133622732346 3.511336974419921 20.263383278435082 -6.8599407108332 1.1860101652017165 0.6981139717633438 3.6597445526231227 0.9535691888956136 0.28755570450474094 0.14686541555523785 0.39257818168396114 0.1891062313378493 0.44140822019214837 1.3805727252512068e-07 6.8599407108332 2.961630580859779 up LK(ub)VVPTTDHIDTEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKVVPTTDHIDTEK 14 1 O75663;O75663-2 O75663 TIPRL TIP41-like protein 1 33858900.0 16375000.0 13874000.0 3609900.0 True False 21467783.57572557 11804053.280428419 3236382.176605929 1.0 0.5498496497689546 0.15075530108592244 24.355669913192497 -7.861957380576747 0.3820826399797873 1.0613966010179106 8.462445407329607e-24 0.9981856126800972 0.014776910534364992 0.10930986384706548 0.07150118218458487 0.03866903246783551 0.0809860233465767 1.3741768230303135e-08 7.861957380576747 -1.0613966010179106 down LK(ub)VVPTTDHIDTEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKVVPTTDHIDTEK 14 1 O75663;O75663-2 O75663 TIPRL TIP41-like protein 1 35850100.0 16375000.0 13550000.0 5925100.0 True False 22429280.017735977 12951316.196142048 4525713.411264945 1.0 0.5774289761374766 0.20177702573092993 24.418879974715388 -7.778547132461855 0.33773931958421904 1.0803010602857406 1.830219823334829e-20 0.9990447470337578 0.010077612688490133 0.11785404288312028 0.0544886766802288 0.03657873441390209 0.08013341385170862 1.665148105275995e-08 7.778547132461855 -1.0803010602857406 down LK(ub)WRPDEEILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKWRPDEEILK 11 2 P10155-3;P10155-5;P10155-4;P10155;G5E9R9 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 1 8104200.0 1595000.0 2717500.0 3791700.0 True False 2091060.4460019732 2312059.5927320323 3399371.256554675 1.0 1.1056875936573718 1.6256685755087288 20.995803335645192 -6.940166294842097 0.658019655120458 0.9941796460420381 1.766577186013907 0.9981855412999833 0.011648322854803465 0.08769093065145864 0.05426582959063989 0.011353074909118079 0.04472105126798854 1.1477140684214757e-07 6.940166294842097 0.7723975399718689 LK(ub)WRPDEEILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKWRPDEEILK 11 2 P10155-3;P10155-5;P10155-4;P10155;G5E9R9 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 1 12897000.0 2383600.0 4316300.0 6197100.0 True False 2307933.9227166763 6039821.099207146 4573893.600985043 1.0 2.6169818120692354 1.9818130649083308 21.138170488830266 -10.359801403031815 5.572225953248278 0.9996481163157466 2.29939743848871 0.8480273750993877 0.25930655518455076 0.0011338701204961375 0.000130271170496655 0.2511353000714111 0.08369083081600949 4.3671549064875063e-11 10.359801403031815 1.2997493221729637 LK(ub)WRPDEEILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKWRPDEEILK 11 2 P10155-3;P10155-5;P10155-4;P10155;G5E9R9 P10155-3 TROVE2 60 kDa SS-A/Ro ribonucleoprotein 1 10276300.0 1595000.0 3117800.0 5563500.0 True False 2184714.6032542847 2980045.2868141425 4249515.883879177 1.0 1.3640432861917786 1.9451125916168763 21.059013397168084 -6.964204399773719 0.3714589731810583 0.9560479238683868 2.373380374983954 0.9998957866900147 0.003973311549944947 0.07823204847575412 0.015818639039907063 0.007642365458562698 0.04931147133646648 1.0859144200171296e-07 6.964204399773719 1.4173324511155674 LK(ub)YALTGDEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKYALTGDEVK 11 1 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 1 14546500.0 2418200.0 4296300.0 7832000.0 True False 3170283.6178821083 3655308.7868462354 7021619.769848931 1.0 1.1529910971461115 2.2148238505360247 21.59618048092193 -6.9328378949491745 0.7231210253391552 0.9854302214469951 2.4494485372832386 0.9970671690382047 0.029256800730748985 0.09119075804109211 0.07065671806304277 0.02711942426664075 0.09462291260639658 1.1672452224966395e-07 6.9328378949491745 1.4640183158362436 up LK(ub)YALTGDEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKYALTGDEVK 11 1 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 1 22534900.0 3621400.0 3620000.0 15293500.0 True False 3506440.6392541425 5065484.878050612 11287673.554834474 1.0 1.4446230235136948 3.219125807655333 21.741575874070158 -6.944926174419285 0.6120194911312844 0.9804256968114545 3.7760546509615454 0.998740537115948 0.03402140545320056 0.08558938835530404 0.044903319984973496 0.034516179666259465 0.1497377185052845 1.1352037721993694e-07 6.944926174419285 2.7956289541500907 up LK(ub)YALTGDEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKYALTGDEVK 11 1 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 1 44925300.0 2276900.0 6504400.0 36144000.0 True False 3454223.7636869242 5343639.0008908445 29000122.557522025 1.0 1.5469869257072162 8.39555412199708 21.71993011261517 -6.9227899972672 0.8037603568696705 0.8635415232250528 9.574084356069523 0.994921540707013 0.2397860506962556 0.09655789569590997 0.09730982697735739 0.20971341591352963 0.6459750390591896 1.1945655960231912e-07 6.9227899972672 8.710542832844471 up LK(ub)YALTGDEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKYALTGDEVK 11 1 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 1 16174000.0 2418200.0 2860400.0 10895400.0 True False 3312273.889397807 2734018.069922116 8322130.917806622 1.0 0.8254202886643467 2.5125129127892376 21.65939054244482 -6.881368420638896 1.0721780369456146 0.88972169584202 2.6352390775923444 0.9747708840539704 0.12032115885475946 0.12642300654874622 0.2650416041139143 0.08633990953292225 0.20952998097724992 1.314109573946908e-07 6.881368420638896 1.7455173817503244 up LK(ub)YALTGDEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKYALTGDEVK 11 1 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 1 17552300.0 3621400.0 6530100.0 7400800.0 True False 3011354.5552218156 6494921.055176629 8948273.06256704 1.0 2.156810477170203 2.9715109590965825 21.521981149504434 -7.956504485240268 0.17131955073093108 2.607809197112218e-21 4.332488382698146 0.9999177565424954 0.00733572085583515 0.11351192978308478 0.028794202171480324 0.2768441629562409 0.35961415889444465 1.1053390537719123e-08 7.956504485240268 4.332488382698146 LK(ub)YALTGDEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKYALTGDEVK 11 1 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 1 34796000.0 2276900.0 11614200.0 20904900.0 True False 2947491.934408941 10967859.560297677 17100422.702387687 1.0 3.72108212825256 5.801686003872586 21.49105643470762 -7.8702692745938885 0.25928282011086407 7.794316723142832e-24 7.6427546257382835 0.9995962069659163 0.03950768224074326 0.12057096656618177 0.04416811915888141 0.37067557505229604 0.6170516015668591 1.34812674752452e-08 7.8702692745938885 7.6427546257382835 LK(ub)YALTGDEVKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKYALTGDEVKK 12 2 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 1 31023900.0 1765000.0 3439900.0 25819000.0 True False 2677634.0387840597 2826022.9689386305 20715863.33313027 1.0 1.055417927918916 7.73662981313815 21.352527365494428 -6.9087170540176945 0.9044257046403966 0.7846492465085833 8.57678700951813 0.9904283782442136 0.30942135773623775 0.10527257716278283 0.14341384985076358 0.25173128357732544 0.6888691574045354 1.2339084716670085e-07 6.9087170540176945 7.7921377630095465 up LK(ub)YQHTGAVLDCAFYDPTHAWSGGLDHQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKYQHTGAVLDCAFYDPTHAWSGGLDHQLK 30 1 O43684-2;O43684;J3QT28;J3QSX4 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 50807000.0 16135000.0 21563000.0 13109000.0 True False 20887075.56839927 20363000.09459963 10723296.509698711 1.0 0.9749091024215698 0.5133938676375707 24.31610717680264 -6.918127036170042 0.8384997692525198 1.0108866679058726 0.4420845810570602 0.9936446249856666 0.01783421498128174 0.09928652807377063 0.11141702826259858 0.015215493580372627 0.044792673695237366 1.2074605872268143e-07 6.918127036170042 -0.5688020868488124 LKDDEVAQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKDDEVAQLK 10 1 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 27098090.0 417090.0 15711000.0 10970000.0 False True 546809.029105306 13366980.040998342 9834929.631670425 1.0 24.445426702023404 17.98604102745419 19.06067753987146 -10.134806634558611 7.158283660336004 0.9999870464926647 21.215733864738798 0.9288750506285227 2.637033159089653 0.0005452162533535512 6.59074827334802e-05 2.553298085275465 0.8510987923792456 7.331508888625772e-11 10.134806634558611 20.215746818246135 LKDDEVAQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKDDEVAQLK 10 1 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 29513700.0 7266600.0 3306100.0 18941000.0 False True 7035925.760535749 4626242.971083741 13979783.88218001 1.0 0.6575173088141676 1.9869146375295927 22.746308829639453 -6.838326281162203 1.29010211956793 0.8177485079763774 2.0292234265162996 0.9215493563195858 0.1578530942068851 0.17075861577448978 0.5527854329295161 0.09596894981802982 0.2210099979388509 1.4510210701570202e-07 6.838326281162203 1.2114749185399223 LKDDEVAQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKDDEVAQLK 10 1 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 23696090.0 417090.0 11642000.0 11637000.0 False True 571299.4444334356 11127617.945054298 8888580.271538058 1.0 19.477732830791897 15.558531271377253 19.12388760139435 -9.212088126346952 9.038136411936364 0.9999994906052861 17.51813205111576 0.9594888540213854 1.600007336689155 0.0 0.0 1.5492004421680483 0.5164001473893494 6.136374741881156e-10 9.212088126346952 16.518132560510473 LKDDEVAQLKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKDDEVAQLKK 11 2 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 9890170.0 2734100.0 922570.0 6233500.0 False True 2647307.492070676 1290957.0121389932 4600759.349008453 1.0 0.4876490607931722 1.7379013819848417 21.336094346900513 -6.795431928969362 1.474450112554872 0.7156528205052076 1.7532815782234725 0.8184694524553046 0.2186451983590764 0.2273514775440422 0.9761937452968635 0.11668465190779244 0.27216007567279216 1.6016516704977213e-07 6.795431928969362 1.0376287577182648 LKDELASTK(ub)QK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKDELASTKQK 11 2 P51572-2;P51572 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 6057900.0 1299000.0 1333700.0 3425200.0 True False 1257763.9560366517 1866253.3651536193 2528037.3662025714 1.0 1.4837866486764197 2.0099457883724754 20.262429767051874 -6.970050555275134 0.2569758387649556 0.846718045233307 2.6625634861754257 0.9999827742395585 0.0017117350425279111 0.0762862884389642 0.00897143195205668 0.011202004974263439 0.04987251851864001 1.0713945792677732e-07 6.970050555275134 1.8158454409421187 LKDELASTK(ub)QK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKDELASTKQK 11 2 P51572-2;P51572 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 4323370.0 1092400.0 887770.0 2343200.0 True False 1496289.800999987 848545.3859371968 1789784.4197188257 1.0 0.5670996256006722 1.1961482451612602 20.512958192393775 -6.721516317640128 1.753609890987439 0.7370513839552156 1.1952657175639863 0.5196810701806456 0.18213431437510505 0.3524282458127822 2.1187916385211074 0.08243737367149166 0.20659993733724868 1.8988194968814765e-07 6.721516317640128 0.4582143336087706 LKDLGNLVLRPFGLSTENFQIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKDLGNLVLRPFGLSTENFQIK 22 2 Q99614;H0YB37 Q99614 TTC1 Tetratricopeptide repeat protein 1 0 35160400.0 14969400.0 8947000.0 11244000.0 False True 19378183.39098826 8449091.584954903 9197707.373182721 1.0 0.4360105080275025 0.47464239488310733 24.20792999576676 -9.949483383756931 5.953625550984729 1.000000303216948 0.4553264534142252 0.9962412355845798 0.01577140176674439 6.34771215958221e-08 1.1198571528909834e-08 0.01527060251606031 0.005090198032331794 1.1233539487264764e-10 9.949483383756931 -0.5446738498027228 LKDVLLQVDDER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKDVLLQVDDER 12 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 11276900.0 2689100.0 3107000.0 5480800.0 False True 3525436.141281444 2643447.7109911423 4913699.3915459635 1.0 0.7498214703246016 1.393784823956535 21.74937031759903 -6.801342938254019 1.45030221181592 0.8621985619807581 1.4029843303961196 0.836092759381609 0.10731358814993187 0.21884596345738336 0.908612739905323 0.058205414095902616 0.13526246982930384 1.5799999082895618e-07 6.801342938254019 0.5407857684153615 LKDVLLQVDDER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKDVLLQVDDER 12 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 7432500.0 1555800.0 1474900.0 4401800.0 False True 1506411.9806018635 2063835.2615018939 3248836.5288305758 1.0 1.370033754429728 2.1566719932302676 20.52268494829108 -6.958834363763409 0.45156876256845685 0.975035364889824 2.582936530144408 0.9997244728625009 0.008005882506870867 0.08012027055969943 0.022690582926983532 0.010539081276083079 0.06505304301034795 1.0994250708908408e-07 6.958834363763409 1.607901165254584 up LKEEMLGK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKEEMLGKLK 10 2 Q99614;H0YB37 Q99614 TTC1 Tetratricopeptide repeat protein 1 1 6654200.0 1806000.0 1571900.0 3276300.0 True False 1748669.518554419 2199567.867350209 2418138.743106824 1.0 1.2578522379509058 1.3828449100581557 20.73782622908485 -12.822631844975675 0.10603630720045427 9.401362545455755e-14 1.6413432760412587 0.9997975006606994 0.0022683201289530296 7.95815747079001 0.08661323328326913 1.9077617413934669 0.21059109064927414 1.504416732205599e-13 12.822631844975675 1.6413432760411648 LKEEMLGK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKEEMLGKLK 10 2 Q99614;H0YB37 Q99614 TTC1 Tetratricopeptide repeat protein 1 1 6463500.0 1806000.0 3562700.0 1094800.0 True False 1501769.0193656022 3543507.027959419 1323717.6182167325 1.0 2.359555285976212 0.8814388904998955 20.518231504519125 -6.664860805965888 1.9554428222676064 1.8715861090882888 0.8875054778281665 0.25658059884744655 0.5781986440005038 0.47300607491529933 3.48172678544563 0.23846141716628652 0.641444021621997 2.1634117993173132e-07 6.664860805965888 -0.9840806312601224 LKEIFDKIHSLLSGKPVQSGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKEIFDKIHSLLSGKPVQSGGR 22 3 Q53GS7;Q53GS7-2 Q53GS7 GLE1 Nucleoporin GLE1 0 32172700.0 7854300.0 6573400.0 17745000.0 False True 11915547.326244537 5400325.411791381 14237692.972090222 1.0 0.4532167313789202 1.1948836744352527 23.506341885712295 -6.709196188958074 1.7981797138361348 0.6635674823880575 1.1930903898348726 0.46119752772790523 0.23044144755337553 0.376712282818577 2.37396398270601 0.10200435180159347 0.2593812594869951 1.9534567983915486e-07 6.709196188958074 0.5295229074468151 LKEIFDKIHSLLSGKPVQSGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKEIFDKIHSLLSGKPVQSGGR 22 3 Q53GS7;Q53GS7-2 Q53GS7 GLE1 Nucleoporin GLE1 0 31509300.0 7854300.0 13109000.0 10546000.0 False True 10167546.181399325 12379472.626262886 8626736.21109791 1.0 1.217547715584523 0.8484580307960441 23.277468207804745 -6.746988001544471 1.6609379932334425 1.1283835557569877 0.8478881284524243 0.635899074816006 0.0914049728464748 0.30534481839455513 1.6563658024364343 0.043490230597037376 0.10592080490555618 1.7906553246189384e-07 6.746988001544471 -0.28049542730456334 LKEIVTNFLAGFEA ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKEIVTNFLAGFEA 14 1 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 10453100.0 5609700.0 2027100.0 2816300.0 False True 5431623.14409453 2836531.6011868515 2078626.5428110238 1.0 0.5222254059121973 0.3826897573096519 22.372951955569825 -13.999999999999943 0.17255944179500657 3.4260001080908693 0.2628981339923235 0.9995090287498637 0.005856882689268105 12.11748134926958 0.13159203088809668 9.842979430991415 0.11116460991182836 1.000000000000131e-14 13.999999999999943 -3.163101974098546 LKEIVTNFLAGFEA ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKEIVTNFLAGFEA 14 1 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 43637300.0 5979300.0 22883000.0 14775000.0 False True 9071035.245383285 18799349.864304963 11854714.773887446 1.0 2.0724591356728457 1.3068756159800965 23.11283577919053 -10.017130710924276 4.362530804200142 0.9999669144568973 1.6896673750109086 0.5196958714433395 0.3125481635715787 217481236.50677627 375886944.9908061 107735.44113258431 0.11438088355733587 9.613229025760021e-11 10.017130710924276 0.6897004605540112 LKEIVTNFLAGFEA ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKEIVTNFLAGFEA 14 1 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 24941000.0 5979300.0 10200000.0 8761700.0 False True 7740321.71962377 9632361.03347938 7167160.502633843 1.0 1.2444393634257847 0.9259512410786737 22.88396210128298 -6.7016553490379005 1.8249599561075243 1.151539510062185 0.9268682503792618 0.4254523319816266 0.10314983753290716 0.39208288201967634 2.5398418379623515 0.04507230504879097 0.11567809866510631 1.987671684352613e-07 6.7016553490379005 -0.22467125968292323 LKEVLEYNAIGGK(ub)YNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKEVLEYNAIGGKYNR 16 2 P14324;P14324-2;A0A087WVN4;A0A087X1D8 P14324 FDPS Farnesyl pyrophosphate synthase 1 250110600.0 3701600.0 44131000.0 202278000.0 True False 5615597.82320854 36255478.25292323 162297664.6384031 1.0 6.456209898629853 28.90122650301769 22.421008186013818 -6.944231924448177 0.6189486788376773 0.7541583436450124 35.79021828555115 0.9986672361023995 0.4407850068866242 0.08588811942449213 0.04620985716306611 0.44433057470030146 1.898776045683279 1.1370199257155104e-07 6.944231924448177 35.03605994190614 LKEVLEYNAIGGK(ub)YNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKEVLEYNAIGGKYNR 16 2 P14324;P14324-2;A0A087WVN4;A0A087X1D8 P14324 FDPS Farnesyl pyrophosphate synthase 1 245702600.0 3701600.0 44988000.0 197013000.0 True False 4791794.169444482 42484378.25236971 161158655.52408817 1.0 8.866069106907188 33.632215789179334 22.192134508106268 -6.95035971439507 0.5548791130197732 0.6669860885284592 43.004558631838805 0.9992292202750066 0.38603867084403215 0.08334159059533694 0.03536686935532936 0.41641895237092064 2.0565250596071367 1.1210895014728564e-07 6.95035971439507 42.337572543310344 LKGDDLQAIKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKGDDLQAIKK 11 2 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-3;G3V2D6;G3V5V7;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 14779920.0 188020.0 8480500.0 6111400.0 False True 246496.04078827033 7215242.4567300845 5479050.952688299 1.0 29.271230619593084 22.22774424760263 17.911204948703283 -9.941329968017927 7.7804424859609345 0.9999998565735533 25.74948743359786 0.9427344320953766 2.8754912702706266 7.077814299867832e-06 9.384824944392806e-07 2.7841824504624246 0.928060816826911 1.144642934813666e-10 9.941329968017927 24.749487577024308 LKGDDLQAIKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKGDDLQAIKK 11 2 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-3;G3V2D6;G3V5V7;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 9824700.0 2832100.0 1295000.0 5697600.0 False True 2742196.53571316 1812100.2533357837 4205227.63566384 1.0 0.6608207069536367 1.5335252528025645 21.386900543409098 -6.801310837898004 1.4505629842310646 0.8131708019265929 1.5459650521526698 0.8359703437367585 0.14548327959496507 0.21888904625697694 0.909142373287988 0.07889644663498148 0.18333882071601032 1.5801166964048162e-07 6.801310837898004 0.7327942502260769 LKGDDLQAIKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKGDDLQAIKK 11 2 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-3;G3V2D6;G3V5V7;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 14591520.0 188020.0 8332300.0 6071200.0 False True 257536.07504944876 7964151.434768586 4637307.600288898 1.0 30.92441101014455 18.006438901417994 17.974415010226174 -9.664366654645917 11.408999639335848 1.00000000000377 24.465424959968654 0.8147989092637516 5.27374002964748 0.0 0.0 5.1062768267630245 1.7020922755876744 2.1658747853079968e-10 9.664366654645917 23.465424959964885 LKGEATVSFDDPPSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKGEATVSFDDPPSAK 16 1 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 88492000.0 24372000.0 42951000.0 21169000.0 False True 31951928.018783726 36542878.22168668 18978634.94738661 1.0 1.1436830416056287 0.5939746401603545 24.929399652010268 -6.837255089880421 1.2950010629676123 1.0764853745279697 0.5768457996916169 0.9196454931746737 0.06598597893606754 0.17202790009460978 0.5615750063000653 0.03997123379213227 0.09203344997000766 1.4546044441933595e-07 6.837255089880421 -0.4996395748363528 LKGEATVSFDDPPSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKGEATVSFDDPPSAK 16 1 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 48906000.0 13827000.0 10817000.0 24262000.0 False True 13388069.453517152 15136284.50990982 17907054.355601676 1.0 1.1305800707460028 1.337538202783774 23.674444604661797 -6.964326282979147 0.3694382171753684 0.9839830586839974 1.4913326936761158 0.9998985675149004 0.0013996100009537617 0.07819039576004311 0.01567101778158064 0.0027302142166383747 0.017582131057879855 1.0856097047487092e-07 6.964326282979147 0.5073496349921184 LKGEATVSFDDPPSAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKGEATVSFDDPPSAK 16 1 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 223351800.0 35641100.0 124247700.0 63463000.0 False True 54070154.413431436 102074727.18328892 50919510.23317896 1.0 1.8878201531071046 0.9417304386415839 25.688329140682747 -6.660531852774635 1.9712657178887314 1.5712466819706654 0.9456966418787078 0.2377165511178998 0.37796940627812653 0.4832132292345685 3.610276171134428 0.15488912546407993 0.4189522782243278 2.1850840515743267e-07 6.660531852774635 -0.6255500400919576 LKGEATVSFDDPPSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKGEATVSFDDPPSAK 16 1 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 72263000.0 24372000.0 23240000.0 24651000.0 False True 33382987.02853503 22213179.955597136 18828941.503281325 1.0 0.6654042053399777 0.5640280627730156 24.99260971353316 -13.999999999999904 0.16729421390745572 2.6757592896489446 0.47197726687370906 0.9995191034516632 0.004085001482153997 12.066374582254983 0.12946488517451332 6.560601505347229 0.08473231102776532 1.0000000000002209e-14 13.999999999999904 -2.2037820227752354 LKGEATVSFDDPPSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKGEATVSFDDPPSAK 16 1 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 37521100.0 13827000.0 13875000.0 9819100.0 False True 11497763.139960246 13800252.621028144 11872228.411611177 1.0 1.2002554282115658 1.032568532426058 23.454849880096074 -10.106296561598718 7.041839632749739 0.9999999407405761 1.116411980318812 0.39120638068083047 0.06845788853762559 6.36725251808842e-08 8.065130586992436e-09 0.06628409913776721 0.022094688518562278 7.828948539326457e-11 10.106296561598718 0.11641203957823587 LKGEATVSFDDPPSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKGEATVSFDDPPSAK 16 1 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 153903100.0 35641100.0 80170000.0 38092000.0 False True 46138106.54111402 75708469.02490619 31159646.856926005 1.0 1.640909753360637 0.675355995139493 25.459455462775196 -6.7277628143379955 1.7315701500669827 1.3866567572368393 0.6761792249256208 0.5487990908459304 0.26947342813994785 0.34043927805976487 1.9987322217562082 0.12338347836791003 0.3069248879941405 1.8717040740613342e-07 6.7277628143379955 -0.7104775323112186 LKGELESSDQVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKGELESSDQVR 12 1 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5;A0A087WU26 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 3915750.0 380550.0 2048200.0 1487000.0 False True 498904.7352514422 1742616.543821069 1333139.5043112058 1.0 3.4928843538492584 2.6721323934504633 18.928404836890692 -10.046241950328634 5.697675629366303 0.9999923372852204 3.082508373650388 0.8956591489376422 0.3350705847295374 3.261501124507054e-05 5.459194507638488e-06 0.3244318845094809 0.10814356620485173 8.989966008989634e-11 10.046241950328634 2.082516036365168 LKGELESSDQVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKGELESSDQVR 12 1 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5;A0A087WU26 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 3447950.0 380550.0 1230800.0 1836600.0 False True 521249.6189770642 1176419.1862886806 1402832.9059643191 1.0 2.256920951994873 2.6912881178068466 18.991614898413584 -9.95224334190277 0.26481841335957057 5.034119114264598e-16 2.90524194358497 0.9990195832546958 0.0224557090135881 1.3869475787532883 0.11820789685452937 1.2280413506534356 0.18047952810561468 1.116237627349657e-10 9.95224334190277 2.9052419435849695 LKGEMMDLQHGSLFLQTPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKGEMMDLQHGSLFLQTPK 19 1 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 37974800.0 8676300.0 19806800.0 9491700.0 False True 11374713.321408719 16851702.6463017 8509589.934815517 1.0 1.4815057021775278 0.7481146728154757 23.439326849523415 -6.729597786517579 1.7245984850114002 1.2899027824582416 0.7485787880667953 0.5573836083084295 0.20242108535176254 0.33702376341826124 1.9635721484572801 0.09301804670022036 0.230931808720774 1.8638124716739608e-07 6.729597786517579 -0.5413239943914463 LKGEMMDLQHGSLFLQTPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKGEMMDLQHGSLFLQTPK 19 1 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 51548700.0 15164800.0 8959900.0 27424000.0 False True 14683401.724791858 12537634.795261236 20240831.697635002 1.0 0.8538644539086845 1.378483819826289 23.80768290234923 -6.832389709824433 1.317345671304516 0.9220375032272677 1.3932876168132189 0.9105431071580928 0.06611935454696473 0.17788180440534804 0.6029024053490797 0.03939969495818701 0.09066190150702581 1.4709919300740158e-07 6.832389709824433 0.47125011358595115 LKGEMMDLQHGSLFLQTPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKGEMMDLQHGSLFLQTPK 19 1 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 73813900.0 6898600.0 62364000.0 4551300.0 False True 10465680.555215683 51234656.94784401 3651733.560094349 1.0 4.895492144780846 0.34892461515791906 23.31916279345552 -6.679883603632628 1.9023462563890086 3.4649772793309026 0.3662610960192644 0.32358820856149906 1.6510427350665042 0.43877172638040896 3.069924807470999 0.696444182948323 1.837068250947267 2.0898561634622257e-07 6.679883603632628 -3.0987161833116383 LKGEMMDLQHGSLFLQTPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKGEMMDLQHGSLFLQTPK 19 1 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 39417500.0 8676300.0 12160500.0 18580700.0 False True 11884162.578191308 11623208.900604071 14192321.341528503 1.0 0.9780418960216756 1.1942214058542846 23.502536911046306 -6.8818690681501025 1.0692719309473768 0.9860213286107604 1.210104833904386 0.9751640811415625 0.015309783967263681 0.1259894780873679 0.2623646687517863 0.01100985959925711 0.026756805078838427 1.312595562949043e-07 6.8818690681501025 0.22408350529362564 LKGEMMDLQHGSLFLQTPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKGEMMDLQHGSLFLQTPK 19 1 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 27617300.0 15164800.0 6678000.0 5774500.0 False True 12610203.114549015 6642024.288520787 6981921.251728652 1.0 0.5267182636303103 0.5536723864243919 23.588088177783508 -10.682453506049288 6.67421001876911 1.0034930225584573 0.5401953250273528 0.9974293251094629 0.011003974551636857 0.0005746300325717295 2.7339802978408277e-05 0.010704610113796344 0.003551517515048316 2.077526125881793e-11 10.682453506049288 -0.4632976975311045 LKGEMMDLQHGSLFLQTPK(ub)IVADKDYSVTANSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKGEMMDLQHGSLFLQTPKIVADKDYSVTANSK 33 3 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 1 26879200.0 7711400.0 7669800.0 11498000.0 True False 11698757.578855177 6301064.26557908 9225415.260247564 1.0 0.5386096962097827 0.7885807700573234 23.479851986327887 -10.073899510776736 5.203657336205271 1.0000051021419394 0.6635952331329181 0.7071581960147657 0.10205026356589238 6.040596554067607e-06 1.074963355535142e-06 0.09881124133387006 0.032936580938578985 8.435299153440514e-11 10.073899510776736 -0.33640986900902126 LKGEMMDLQHGSLFLQTPK(ub)IVADKDYSVTANSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKGEMMDLQHGSLFLQTPKIVADKDYSVTANSK 33 3 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;F5H793 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 1 29859300.0 7711400.0 9403900.0 12744000.0 True False 9982559.314419216 8880564.698307525 10424722.764482442 1.0 0.8896080071850989 1.0442935960745605 23.250978308420336 -6.715109705217514 1.7771791662412066 0.9324904895123979 1.043984974161474 0.4892789598162286 0.04648319489915918 0.36487862977338215 2.2494826174333182 0.020791293748825098 0.05249125060147296 1.92703807109878e-07 6.715109705217514 0.11149448464907608 LKGEMMDLQHGSLFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKGEMMDLQHGSLFLR 16 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 0 8037900.0 3095300.0 2261700.0 2680900.0 False True 4057968.274927842 1924263.17603755 2403506.1850086832 1.0 0.47419374565508815 0.5922929954526128 21.952326155517024 -9.84674989440767 6.557674818793057 1.0000000127776603 0.5332433705539028 0.9541850552213058 0.04821381683505197 9.04262149854548e-09 1.5911776604676242e-09 0.04668282880600223 0.015560942471582438 1.4231481271087967e-10 9.84674989440767 -0.46675664222375746 LKGEMMDLQHGSLFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKGEMMDLQHGSLFLR 16 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 0 26662600.0 4085200.0 16808000.0 5769400.0 False True 6197547.068125005 13808481.078496618 4629075.561182146 1.0 2.2280558625388887 0.7469205978265556 22.563265892424017 -6.686575072041227 1.8785150668907111 1.772383094303634 0.752242239411196 0.3544049620804369 0.5197506933867245 0.42411534606155554 2.8989190153158613 0.22156103795449247 0.5794786213370029 2.0579031311471112e-07 6.686575072041227 -1.0201408548924382 LKGEMMDLQHGSLFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKGEMMDLQHGSLFLR 16 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 0 9209300.0 3095300.0 3017500.0 3096500.0 False True 4239716.057337296 2884176.8724618885 2365170.4744193153 1.0 0.680275950902538 0.5578605836884116 22.015536217039916 -13.999999999999998 0.13300393289181495 2.520546679820883 0.3927913214168505 0.9996322349907834 0.0035745775280277667 11.933244103906112 0.1136983952268398 4.731510879687089 0.14698511551121998 1.0000000000000041e-14 13.999999999999998 -2.1277553584040327 LKGEMMDLQHGSLFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKGEMMDLQHGSLFLR 16 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;P00338-4;F5GYU2;F5GXH2;F5H5J4;F5H6W8 P00338 LDHA L-lactate dehydrogenase A chain 0 17541400.0 4085200.0 7409800.0 6046400.0 False True 5288371.931330935 6997438.116262313 4946017.241303097 1.0 1.3231743544371422 0.9352627435299021 22.334392214516466 -6.685654822073681 1.8824573826901796 1.2034357962716276 0.9366906731046415 0.3499331060986678 0.1368038045650056 0.42605624545333187 2.923848766549794 0.058220488284461074 0.15241212397014345 2.0622683561462587e-07 6.685654822073681 -0.26674512316698606 LKGPQITGPSLEGDLGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKGPQITGPSLEGDLGLK 18 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 12322900.0 3032100.0 5282300.0 4008500.0 False True 3975112.462898165 4494201.430244125 3593738.872247122 1.0 1.1305847248828538 0.9040596727235758 21.922564246669666 -6.7503651737098895 1.6483114702626795 1.0767496207622462 0.9035915109991589 0.6506394940648015 0.0548736675661532 0.29939629604317153 1.6005211228805392 0.026296200800967666 0.06382015699062812 1.7767847837448451e-07 6.7503651737098895 -0.17315810976308732 LKGPQITGPSLEGDLGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKGPQITGPSLEGDLGLK 18 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 12445800.0 3892800.0 2168200.0 6384800.0 False True 3769225.19481099 3033973.5670136274 4712429.340105743 1.0 0.8049329531147231 1.2502382045501663 21.84583656165506 -6.787628553076365 1.5056561398735595 0.8906385996619268 1.2546781504139999 0.7935770438677818 0.08280745265999667 0.23891400118647058 1.069994102026181 0.0432942382058998 0.10154629285394509 1.6306901463274517e-07 6.787628553076365 0.36403955075207306 LKGPQITGPSLEGDLGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKGPQITGPSLEGDLGLK 18 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 16940500.0 3032100.0 3908400.0 10000000.0 False True 4153149.3094215086 3735713.9646495627 7638205.956464768 1.0 0.8994894443537137 1.839135891198839 21.985774308192557 -6.880430902018262 1.077341797297914 0.9373359568893582 1.906294482167018 0.9740335411268656 0.06788330398600285 0.1272514137947112 0.2699573336193901 0.04851731187196929 0.11746179497470242 1.316949427952832e-07 6.880430902018262 0.9689585252776598 LKGSGNLEAIHIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKGSGNLEAIHIIK 14 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 15734400.0 4738100.0 5118500.0 5877800.0 False True 6211694.983825662 4354839.75175673 5269621.639838868 1.0 0.7010710865707492 0.848338763181416 22.56655555936397 -10.142492038750232 4.843897439242579 1.0000158150626501 0.7747049248749656 0.7573123059417253 0.06012177722074183 15610602.345415419 32686574.004749894 1732.9136613099045 0.020581284620060872 7.202909550985743e-11 10.142492038750232 -0.22531089018768458 LKGSGNLEAIHIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKGSGNLEAIHIIK 14 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 75753000.0 8674000.0 47966000.0 19113000.0 False True 13159092.15434159 39406092.539931454 15335307.172474502 1.0 2.9945905141282996 1.1653772914277305 23.649556625198986 -6.625629159699242 2.0965809768746873 2.318253527953476 1.1726385916977513 0.10187801799651908 0.856529109719219 0.5704885970732488 4.772913537168113 0.3348274574035497 0.9489991323759361 2.3679407986240495e-07 6.625629159699242 -1.1456149362557246 LKGSGNLEAIHIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKGSGNLEAIHIIK 14 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 13259200.0 4738100.0 4280700.0 4240400.0 False True 6489903.612337998 4091564.5196180977 3238904.8537793187 1.0 0.6304507376410949 0.49906825235767993 22.62976562088686 -13.999999999999998 0.14405149031796663 2.7726065322294065 0.3441468142026224 0.9995872868558048 0.00430825735074964 11.940355335278786 0.11919337990500654 5.9373727158211915 0.13890950505454625 1.0000000000000041e-14 13.999999999999998 -2.428459718026784 LKGSGNLEAIHIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKGSGNLEAIHIIK 14 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 52312000.0 8674000.0 24344000.0 19294000.0 False True 11228663.990101954 22989234.99990414 15782689.973157888 1.0 2.0473704636784134 1.4055714898112812 23.420682947291436 -10.213458480946406 5.831328130555448 0.9999938322022337 1.7264709763958606 0.6307717088807929 0.2620133340045872 6.411124400974486e-05 8.647187091585087e-06 0.2536998773940902 0.08456443990832772 6.117042797943737e-11 10.213458480946406 0.7264771441936269 LKLEDFFAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKLEDFFAR 9 1 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 7502800.0 2024000.0 2128200.0 3350600.0 False True 2653483.600443882 1810680.855658628 3003912.0532247005 1.0 0.6823787625277701 1.1320635457186161 21.33945620168727 -6.716959911553614 1.7705456814259597 0.8061366787986917 1.13123263346932 0.49803214002472873 0.133708221288013 0.36124193356057754 2.211512996231526 0.0600054646133817 0.15116088183920373 1.9188458555133804e-07 6.716959911553614 0.32509595467062824 LKLEDFFAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKLEDFFAR 9 1 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 8956400.0 2024000.0 3157400.0 3775000.0 False True 2772327.4965433665 3017895.627874452 2883422.748565448 1.0 1.0885783269246756 1.040072917849929 21.40266626321016 -10.110887958115406 4.036790232563759 0.999984552713426 1.0643256224087587 0.7010383741495476 0.019802250422653503 10431015.955740504 0.13321786170931113 1606.195790665593 0.007246881597907562 7.746616238582273e-11 10.110887958115406 0.06434106969533271 LKLEDFFAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKLEDFFAR 9 1 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 5007200.0 1903900.0 1628400.0 1474900.0 False True 1583177.207070971 1619627.4859879082 1783294.7708329025 1.0 1.023023499046183 1.1264025043236747 20.59439131655797 -6.942229338349303 0.6384823646958592 0.9988693782672502 1.1562098055533003 0.998441607634525 0.0021699978143397336 0.08676402920668072 0.05008665369641681 0.0021498927708345937 0.008813930463635038 1.1422749731340269e-07 6.942229338349303 0.15734042728605013 LKLGEIVTTIPTIGFNVETVEYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKLGEIVTTIPTIGFNVETVEYK 23 1 P84077;P61204;F5H423;F5H0C7;P18085;C9JPM4;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 70770000.0 18353000.0 18641000.0 33776000.0 False True 27842842.78402479 15314367.907202225 27100158.795453306 1.0 0.5500288898656948 0.9733258563311068 24.730803183625035 -10.583378581373163 9.37255951828798 1.0000296726432092 0.7616773730984008 0.29708551202913047 0.1728102629180436 0.00010716185388627176 4.763238528361863e-06 0.16734358250194242 0.05577427252794234 2.6098852841929904e-11 10.583378581373163 -0.2383522995448084 LKLGEIVTTIPTIGFNVETVEYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKLGEIVTTIPTIGFNVETVEYK 23 1 P84077;P61204;F5H423;F5H0C7;P18085;C9JPM4;P84085;C9J1Z8 P84077;P18085;P84085 ARF1;ARF3;ARF4;ARF5 ADP-ribosylation factor 1;ADP-ribosylation factor 3;ADP-ribosylation factor 4;ADP-ribosylation factor 5 0 44831800.0 18353000.0 9367800.0 17111000.0 False True 23758320.29171559 8846473.695041994 13996973.573686346 1.0 0.3723526573604918 0.5891398635015045 24.501929505717484 -10.10661472808744 5.144188431470255 1.0000131715672125 0.4807462604301339 0.8843858285766188 0.08850300630459218 1.3369810964194549e-05 2.3220217945345447e-06 0.0856948385744018 0.028564222458471074 7.823215109667697e-11 10.10661472808744 -0.5192669111370786 LKLPAVVTADLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKLPAVVTADLR 12 1 P38117-2;P38117;M0QY67 P38117-2 ETFB Electron transfer flavoprotein subunit beta 0 8854000.0 2660500.0 6193500.0 0.0 False True 3487941.2643186525 5269453.942073916 0.0 1.0 1.5107633823940756 0.0 21.73394431517592 -6.83573197597225 1.4393803694642495 1.2751878241973298 3.6397766250662525e-21 0.873011798962076 0.22359572071734282 0.18870788024517673 0.7846300547442601 0.12445432801211412 0.2677059638457366 1.459714842637129e-07 6.83573197597225 -1.2751878241973298 down LKLPAVVTADLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKLPAVVTADLR 12 1 P38117-2;P38117;M0QY67 P38117-2 ETFB Electron transfer flavoprotein subunit beta 0 8997200.0 3150400.0 0.0 5846800.0 False True 4779387.125090817 0.0 4691177.417256523 1.0 0.0 0.9815437198273371 22.188394198350075 -11.95311267941659 13.991946471114002 0.8645646459624531 0.5416946739223184 0.0 0.4819903439041487 0.0 0.0 0.0 0.1376345274087561 1.1140054629810562e-12 11.95311267941659 -0.3228699720401347 LKLPAVVTADLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKLPAVVTADLR 12 1 P38117-2;P38117;M0QY67 P38117-2 ETFB Electron transfer flavoprotein subunit beta 0 11937700.0 2660500.0 2732800.0 6544400.0 False True 3644158.747309107 2612055.859838887 4998747.50614881 1.0 0.7167788345575402 1.371715079602377 21.79715437669881 -6.789174976206647 1.499528724019381 0.8415348454926579 1.3785321269503725 0.7986543751371725 0.12034054593699595 0.23659264161672097 1.0509827536317722 0.06316931896877045 0.1479905125302257 1.62489395796698e-07 6.789174976206647 0.5369972814577146 LKLPAVVTADLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKLPAVVTADLR 12 1 P38117-2;P38117;M0QY67 P38117-2 ETFB Electron transfer flavoprotein subunit beta 0 6409200.0 3288600.0 1554700.0 1565900.0 False True 2734616.609682017 1546324.5225162106 1893322.4500964396 1.0 0.5654630038599884 0.6923538909962945 21.382907152220707 -10.538455601055997 9.391988781942723 1.0000171656894399 0.6289084474281442 0.9193779079680897 0.05180298774883997 1.8620700971264745e-05 9.150933833648988e-07 0.05016034032255025 0.016719342402920338 2.8943056936035586e-11 10.538455601055997 -0.37110871826129566 LKLPAVVTADLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKLPAVVTADLR 12 1 P38117-2;P38117;M0QY67 P38117-2 ETFB Electron transfer flavoprotein subunit beta 0 16117000.0 3150400.0 6613000.0 6353600.0 False True 4078254.903668111 6244980.7367058 5197309.993441278 1.0 1.531287495317879 1.2743955726667928 21.959520520442524 -10.040404128102184 4.400142556047628 0.9999764717429668 1.4028415339720404 0.7662860637418805 0.10487568842986723 24381827.83090507 32497704.33230365 6543.807757532692 0.038380572486690995 9.111625721221917e-11 10.040404128102184 0.4028650622290736 LKLPSIPLVPVSAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKLPSIPLVPVSAQK 15 1 Q15785 Q15785 TOMM34 Mitochondrial import receptor subunit TOM34 0 12749500.0 2900100.0 3164600.0 6684800.0 False True 3802059.184608348 2692454.0155141847 5993121.02112948 1.0 0.7081567868311697 1.576282937780421 21.858349559142408 -6.81602989891253 1.3888701999016957 0.8420349797341721 1.59368262006236 0.8750214299049498 0.12751452837191837 0.19869554180836935 0.754144959948476 0.07216519051312559 0.16653821346190892 1.52746089689309e-07 6.81602989891253 0.7516476403281879 LKLPSIPLVPVSAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKLPSIPLVPVSAQK 15 1 Q15785 Q15785 TOMM34 Mitochondrial import receptor subunit TOM34 0 17161100.0 6292500.0 3659900.0 7208700.0 False True 6092748.031840357 5121317.156126359 5320525.213635548 1.0 0.8405594863537182 0.8732554154267965 22.538661647652333 -10.35062145601092 5.744047101608154 1.0000266413407306 0.8569074508902574 0.9623180556940576 0.013348057149213782 4.554852203410769e-06 5.149448347249573e-07 0.012926605323281064 0.004308066920260539 4.4604486498051306e-11 10.35062145601092 -0.14311919045047317 LKLPSIPLVPVSAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKLPSIPLVPVSAQK 15 1 Q15785 Q15785 TOMM34 Mitochondrial import receptor subunit TOM34 0 14311400.0 2900100.0 5294700.0 6116600.0 False True 3972345.3422556384 5060762.646768508 4671985.055331245 1.0 1.2739986609257963 1.1761276155004001 21.9215596206653 -10.108578811175006 4.320606596667474 0.9999696369485178 1.22506313823166 0.8757888956853022 0.03995568705936949 27836234.745272063 0.6478527426332633 8773.90815723555 0.013677894427707723 7.787914748793681e-11 10.108578811175006 0.2250935012831421 LKLPSIPLVPVSAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKLPSIPLVPVSAQK 15 1 Q15785 Q15785 TOMM34 Mitochondrial import receptor subunit TOM34 0 9886500.0 6292500.0 1534200.0 2059800.0 False True 5232492.555015534 1525934.9600851424 2490494.6565608606 1.0 0.2916267809349252 0.47596716677095524 22.31906692308661 -10.84874779869475 10.923683942751541 1.0137243752533782 0.38379697385754463 0.9371013722603827 0.07525664738100817 0.022976456710607728 0.0003181373754926891 0.06655869762343082 0.024288978499837386 1.416616191363926e-11 10.84874779869475 -0.6299274013958336 LKLSILYPATTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKLSILYPATTGR 13 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 30633800.0 12367000.0 6384800.0 11882000.0 False True 16213256.762198374 5432212.72775547 10652564.620192166 1.0 0.33504759761905545 0.657028058978804 23.950670578802047 -10.559021178759274 6.466871222420595 1.0007089974773957 0.49603782829916754 0.7656129164867183 0.13144797291288324 0.001345416096033284 9.174435265660647e-05 0.12743875210577965 0.04242465083202672 2.7604432374518184e-11 10.559021178759274 -0.5046711691782282 LKLSILYPATTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKLSILYPATTGR 13 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 8369100.0 2869000.0 2692500.0 2807600.0 False True 2777925.1654112004 3767629.291202008 2072205.3338054293 1.0 1.35627458151642 0.7459543401698125 21.405576304372655 -6.748480024268364 1.655513399216334 1.209877265033051 0.7448844032211788 0.6423721869267022 0.1496990845943745 0.302711277644993 1.6318647047596473 0.07144662120402473 0.17372784212316886 1.7845140668438947e-07 6.748480024268364 -0.46499286181187216 LKLSILYPATTGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKLSILYPATTGR 13 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 81807000.0 21449000.0 18801000.0 41557000.0 False True 32539701.131942876 15445814.65711654 33343240.73491988 1.0 0.47467598409974404 1.0246941297868346 24.95569766453224 -10.959085951835524 12.893148292383378 1.0742977883663931 0.7496850569432894 0.2163982136916338 0.2245439677008587 0.10633824333013099 0.00033744457138562025 0.04821013600315258 0.07247125394973015 1.0987883551535538e-11 10.959085951835524 -0.32461273142310376 LKLSILYPATTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKLSILYPATTGR 13 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 42432300.0 12367000.0 21616000.0 8449300.0 False True 16939414.105608616 20660933.645446938 6453749.358795775 1.0 1.2196958830238487 0.38099011681041245 24.01388064032494 -6.837097117012357 1.2957210445298075 1.116957196264826 0.35493860623510676 0.9193552391576627 0.10084149705332028 0.17222203612652245 0.5628981427296753 0.06105197589947118 0.14056821291485258 1.4551336469413303e-07 6.837097117012357 -0.7620185900297192 down LKLSILYPATTGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKLSILYPATTGR 13 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 8000800.0 2869000.0 2607900.0 2523900.0 False True 2385700.6182502285 2593850.7250723816 3051635.8208049093 1.0 1.08724904760884 1.2791361151773961 21.18598157980693 -6.9581454697577225 0.4608293258920363 0.994452914400871 1.3796783187663475 0.9996951025164926 0.0020358976018705517 0.0803704092747396 0.023630543810720404 0.002609735659082946 0.01585037930611676 1.1011704035816835e-07 6.9581454697577225 0.3852254043654765 LKLSILYPATTGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKLSILYPATTGR 13 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 109146000.0 21449000.0 35575000.0 52122000.0 False True 27766153.322999377 33595219.97706167 42636330.816882715 1.0 1.2099342529105006 1.5355505071552713 24.72682398662469 -6.96469531073979 0.3632459314130311 0.9729618014192746 1.7837379270581906 0.9999067226522326 0.0021279556215210993 0.07806453621859043 0.015225603830959058 0.004341141684038894 0.027758684028673136 1.0846876346415928e-07 6.96469531073979 0.810776125638916 LKLVLLELNFLPTTGTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKLVLLELNFLPTTGTK 17 1 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 80129000.0 15127000.0 29160000.0 35842000.0 False True 22948764.93183365 23956170.17188012 28757812.98989336 1.0 1.0438980155593922 1.2531311848508944 24.451913176252994 -6.9408782980686965 0.6513414010172567 0.9976823669333312 1.3110430628607372 0.998276691504404 0.004584831841613753 0.08736820223611802 0.05280205281504223 0.0044932703440387755 0.017939730117191608 1.1458339924339025e-07 6.9408782980686965 0.313360695927406 LKLVLLELNFLPTTGTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKLVLLELNFLPTTGTK 17 1 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 64593000.0 15127000.0 22520000.0 26946000.0 False True 19582199.69774869 21266742.203329 22042104.48930819 1.0 1.0860241715221592 1.1256194313983177 24.223039498345443 -13.999999999999181 0.10413326092788518 0.5798341821817173 1.2047988043543656 0.9997728614029515 0.0007902860181891684 12.050330941202946 0.09691192916846304 1.0773621454102262 0.07046994732987638 1.0000000000018855e-14 13.999999999999181 0.6249646221726483 LKPDEGGEVPVLNVSYKPQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKPDEGGEVPVLNVSYKPQK 20 2 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 30246600.0 5705200.0 9630200.0 14911200.0 False True 7479572.449235387 8193411.698225588 13368332.062330365 1.0 1.0954385098660517 1.7873123300914033 22.83452437379576 -6.931976630423362 0.7303831584610053 0.9902122848985999 1.9367758161612787 0.9969127317901915 0.019492559480699816 0.09162418299264785 0.07274622663367719 0.017972286693148206 0.06193611720016157 1.1695623239884836e-07 6.931976630423362 0.9465635312626788 LKPDEGGEVPVLNVSYKPQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKPDEGGEVPVLNVSYKPQK 20 2 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 15435650.0 5009800.0 3777250.0 6648600.0 False True 4850766.641225875 5285525.623098536 4907132.206275379 1.0 1.0896268598406107 1.011619929223241 22.209781345920575 -10.72347186880072 3.665631615938233 0.995094299811226 1.0506233945326555 0.35960345156700146 0.03184619607123048 0.0013986798782132132 0.00010551360743496851 0.03377945040680633 0.010278315585012786 1.890288669687248e-11 10.72347186880072 0.05552909472142953 LKPDEGGEVPVLNVSYKPQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKPDEGGEVPVLNVSYKPQK 20 2 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 24407300.0 5705200.0 8146500.0 10555600.0 False True 7814566.617232808 7786560.693127009 8062584.679405964 1.0 0.9964161897290581 1.0317379164221625 22.89773443531865 -6.881899835656946 1.0691124304376345 0.9977175236382235 1.034334513981716 0.9751871077606199 0.0025004327758043443 0.12596211629407458 0.26221139988287084 0.001798390908475249 0.004370867519729761 1.312502575669355e-07 6.881899835656946 0.03661699034349242 LKPDEGGEVPVLNVSYKPQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKPDEGGEVPVLNVSYKPQK 20 2 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 8090900.0 5009800.0 1853500.0 1227600.0 False True 4165870.6717706514 1843514.8276090547 1484285.4842189085 1.0 0.44252809865206205 0.35629658267524456 21.99018662135485 -13.999999999999998 0.26273895828047666 5.139903144594128 0.3255966668487385 0.9995679722132708 0.005930037341700612 14.539933178573783 0.1622155558993647 32.01213131449987 0.03716305882392158 1.0000000000000041e-14 13.999999999999998 -4.814306477745389 LKPGDLVGVNK(ub)DSYLILETLPTEYDSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKPGDLVGVNKDSYLILETLPTEYDSR 27 2 E9PMD8;E9PLG2;P17980;R4GNH3;E9PM69;E9PKD5 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 113043000.0 62285000.0 12389000.0 38369000.0 True False 94490898.64343621 10178086.154301187 30785350.332269873 1.0 0.1077149894902413 0.3258022812169368 26.493672039954525 -10.358067740346685 4.955951473966156 1.000515834620474 0.21675863595960132 0.945047866427983 0.08903376401997583 0.0005077671437755422 6.577007205711607e-05 0.08626030855067998 0.02873552377486653 4.384623020064451e-11 10.358067740346685 -0.7837571986608728 LKPGDLVGVNK(ub)DSYLILETLPTEYDSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKPGDLVGVNKDSYLILETLPTEYDSR 27 2 E9PMD8;E9PLG2;P17980;R4GNH3;E9PM69;E9PKD5 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 105396000.0 62285000.0 12066000.0 31045000.0 True False 80629160.32090154 11394516.49313356 25395128.548599884 1.0 0.1413200441103906 0.31496208626665667 26.264798362046974 -10.207228235558604 7.836437390738344 1.0000004731856764 0.22814106782407487 0.9634307812722914 0.0708890668629497 5.860331884628639e-07 5.9385206233269093e-08 0.068638085776298 0.022879347949032364 6.205428335340123e-11 10.207228235558604 -0.7718594053616016 LKPGTMIEWGNNWAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKPGTMIEWGNNWAR 15 1 Q9BPW8;C9JDV8 Q9BPW8 NIPSNAP1 Protein NipSnap homolog 1 0 17340100.0 4818000.0 5291400.0 7230700.0 False True 6316444.657578375 4501943.745715656 6482536.5257720435 1.0 0.7127338225490968 1.0262951513387193 22.59068130523143 -6.6657566280077 1.9523883514623785 0.8159710189781778 1.0250063800092724 0.2603241987143574 0.12214577165535025 0.4709842420978843 3.4569541956431005 0.050439621013801235 0.13551349189222436 2.1589539150151564e-07 6.6657566280077 0.20903536103109455 LKPGTMIEWGNNWAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKPGTMIEWGNNWAR 15 1 Q9BPW8;C9JDV8 Q9BPW8 NIPSNAP1 Protein NipSnap homolog 1 0 18513500.0 5987500.0 2781100.0 9744900.0 False True 5797430.089891799 3891607.7332449052 7192418.349266449 1.0 0.6712642796728467 1.2406218337685355 22.466982087114896 -6.750184900692093 1.6495499288114324 0.8067393059730605 1.241742547376696 0.6496135287290699 0.13813694707669436 0.29972000552906736 1.6047050177788675 0.06615665583979505 0.1605547688147915 1.7775224694767762e-07 6.750184900692093 0.43500324140363555 LKPGTMIEWGNNWAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKPGTMIEWGNNWAR 15 1 Q9BPW8;C9JDV8 Q9BPW8 NIPSNAP1 Protein NipSnap homolog 1 0 17263500.0 4818000.0 5710300.0 6735200.0 False True 6599344.801554323 5458000.064563094 5144484.475798154 1.0 0.8270518102460093 0.7795447321659098 22.653891366754323 -13.999999716068924 0.18130638391002277 1.9009776006514685 0.7423120225261898 0.999496617609619 0.0021254320551821336 12.221874870321008 0.13499242598853842 3.8803524757634396 0.035080445496051674 1.0000006537756767e-14 13.999999716068924 -1.1586655781252788 LKPGTMIEWGNNWAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKPGTMIEWGNNWAR 15 1 Q9BPW8;C9JDV8 Q9BPW8 NIPSNAP1 Protein NipSnap homolog 1 0 13240700.0 5987500.0 2993200.0 4260000.0 False True 4978871.541224556 2977075.0374963162 5150746.303985457 1.0 0.5979417249162655 1.0345208269258999 22.247387362549173 -6.664606796613639 1.9564483777493986 0.7421894075006491 1.032722941140336 0.25541233481297254 0.17100030399908117 0.47361396300181724 3.4895640211616863 0.0704959541821274 0.18968509267330186 2.1646775017085461e-07 6.664606796613639 0.2905335336396869 LKPGYLEATVDWFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKPGYLEATVDWFR 14 1 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 13991900.0 4861600.0 6015700.0 3114600.0 False True 6373604.6798013635 5118181.009014938 2792331.0693528433 1.0 0.8030276846687718 0.43810860723791667 22.603678108650655 -6.9615136891330485 0.4135494640601369 1.0172951403001607 0.21022005945559186 0.9998222807846876 0.0031032396472961267 0.07916478427039667 0.019165759239013123 0.004704666781991012 0.030433933776587128 1.0926631854723238e-07 6.9615136891330485 -0.8070750808445688 down LKPGYLEATVDWFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKPGYLEATVDWFR 14 1 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 68426000.0 28574000.0 18517000.0 21335000.0 False True 27666934.01061681 25910934.664879344 15746723.463719457 1.0 0.9365307574354418 0.5691531796648254 24.721659440694314 -6.936600415997435 0.6904696734662902 1.0044650319432684 0.4792652849034957 0.9976837824995072 0.009140256450735082 0.08935252665201314 0.061933268072958125 0.008682902892718752 0.03212155695059312 1.1571764430111633e-07 6.936600415997435 -0.5251997470397727 LKPGYLEATVDWFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKPGYLEATVDWFR 14 1 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 212490800.0 52431000.0 89455000.0 70604800.0 False True 79541660.21953923 73491056.33489485 56649730.33281688 1.0 0.9239316369818736 0.7122020105748434 26.245207339071523 -6.953122025140788 0.5234476042891855 1.0035043544279363 0.6231246904127754 0.9994240630108441 0.0029222281344259936 0.08225578613894492 0.030957489956799148 0.003292634123660394 0.017495238928485566 1.1139814905931354e-07 6.953122025140788 -0.3803796640151609 LKPGYLEATVDWFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKPGYLEATVDWFR 14 1 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 23580600.0 4861600.0 7003000.0 11716000.0 False True 6659064.899800007 6693584.304175845 8948922.098594125 1.0 1.005183821586853 1.3438706835343939 22.666888170173547 -6.910231295634029 0.8941759313037091 0.9895894016126926 1.3878546699545935 0.9910077159069879 0.01525722566483929 0.10426611275654507 0.1379474388383866 0.0125054585938501 0.03457550630053063 1.2296137313250887e-07 6.910231295634029 0.3982652683419009 LKPGYLEATVDWFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKPGYLEATVDWFR 14 1 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 54640000.0 28574000.0 13326000.0 12740000.0 False True 23760547.04283096 13254210.192996087 15403875.09689548 1.0 0.557824286162433 0.6482963152796242 24.50206471612859 -9.94465439273539 5.632395495604375 1.0000004514406797 0.6030603007205323 0.9624991411849058 0.036935051223695614 2.0941621347102928e-07 3.9169915806718826e-08 0.03576225006842826 0.011920736523128332 1.135914405569413e-10 9.94465439273539 -0.39694015072014743 LKPGYLEATVDWFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKPGYLEATVDWFR 14 1 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 172157300.0 52431000.0 65579000.0 54147300.0 False True 67872963.06952214 61929471.00142596 44293046.99821561 1.0 0.9124321114136674 0.6525874957432803 26.016333661163973 -6.951696307304618 0.5398986412055237 1.0038281335208397 0.5491938956422475 0.9993277740308742 0.0038250230256490513 0.0828116259858375 0.03319790057537887 0.004207676635036116 0.0215184684250441 1.1176445191151098e-07 6.951696307304618 -0.45463423787859214 LKPKPIDVQVITHHMQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKPKPIDVQVITHHMQR 17 2 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 0 19261600.0 4066300.0 6625900.0 8569400.0 False True 5330958.678105217 5637341.5475559095 7682720.691489207 1.0 1.0574723774748127 1.441151799402031 22.34596356868378 -6.9336197178078445 0.7164522720001402 0.9948759484967591 1.527709446410971 0.9972031670357042 0.010356236667326057 0.09080117418047022 0.06878738469639853 0.009647131416808103 0.034051773910488525 1.1651458219545792e-07 6.9336197178078445 0.532833497914212 LKPKPIDVQVITHHMQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKPKPIDVQVITHHMQR 17 2 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 0 12338100.0 2648300.0 971600.0 8718200.0 False True 2564231.166106131 1359564.9468270666 6434641.87960624 1.0 0.5302037370100335 2.5093844754166432 21.29009489647655 -6.844105530492141 1.263303400785379 0.7500640165504442 2.579905757956673 0.9312664037070844 0.22135995524408525 0.16406064122916625 0.5068413618939872 0.13730022017173887 0.3167291556599225 1.431839930006795e-07 6.844105530492141 1.829841741406229 up LKPKPIDVQVITHHMQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKPKPIDVQVITHHMQR 17 2 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 0 14346100.0 4066300.0 4513900.0 5765900.0 False True 5569720.99762564 4314460.972528818 4404113.17243802 1.0 0.774627844800137 0.7907241986296053 22.40917363020667 -10.240827369257078 5.414344921548537 1.000016853308425 0.7826760217148528 0.9959025076469769 0.006571308933647283 1.3369587762824931e-06 1.874758949004821e-07 0.006363135609105062 0.002120880838557196 5.7434471712680816e-11 10.240827369257078 -0.2173408315935722 LKPKPIDVQVITHHMQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKPKPIDVQVITHHMQR 17 2 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 0 6801700.0 2648300.0 3061100.0 1092300.0 False True 2202178.7895824634 3044609.246719223 1320694.8797754268 1.0 1.382544079128328 0.5997219145071471 21.070500171910826 -6.773831244007138 1.5598498118862927 1.2183411993225637 0.5946730301367142 0.7449805731247494 0.1614028743122844 0.26027710049949443 1.2503162524270643 0.08153632407853198 0.19341140867785106 1.6833280332505475e-07 6.773831244007138 -0.6236681691858494 LKPNLGNGADLPNYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKPNLGNGADLPNYR 15 1 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 0 12892800.0 3688500.0 1633900.0 7570400.0 False True 3571410.5864828248 2286324.790675938 5587485.132868148 1.0 0.6401741651685988 1.5645037157071269 21.76806257192123 -6.8011409838924095 1.4512501245481761 0.8017504155131125 1.5776240112891529 0.8354614460775184 0.15431405464705564 0.2191438180660787 0.9110810804452043 0.08364572889318418 0.19439545076396172 1.580734806125666e-07 6.8011409838924095 0.7758735957760403 LKPQLLQGVYAMGFNRPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKPQLLQGVYAMGFNRPSK 19 2 Q9NUU7;F6QDS0;Q9UMR2;H3BQK0;H3BTB3;H3BMQ5;H3BN59 Q9NUU7 DDX19A;DDX19B ATP-dependent RNA helicase DDX19A;ATP-dependent RNA helicase DDX19B 0 30797200.0 9261600.0 14158600.0 7377000.0 False True 12142047.289461976 12046192.069790537 6613698.805180745 1.0 0.9921055142196133 0.5446938763713054 23.533508361368007 -6.9107273954681965 0.8907693286149462 1.013536087951618 0.4859652222954417 0.9911931227065709 0.019969928306809524 0.10393890991018845 0.13617365425888384 0.016408677251916172 0.04552677851663845 1.2282099306445186e-07 6.9107273954681965 -0.5275708656561763 LKPQLLQGVYAMGFNRPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKPQLLQGVYAMGFNRPSK 19 2 Q9NUU7;F6QDS0;Q9UMR2;H3BQK0;H3BTB3;H3BMQ5;H3BN59 Q9NUU7 DDX19A;DDX19B ATP-dependent RNA helicase DDX19A;ATP-dependent RNA helicase DDX19B 0 40545200.0 10962100.0 7571100.0 22012000.0 False True 10614114.135850163 10594279.712764908 16246396.854154814 1.0 0.9981313162048764 1.5306408661351294 23.339480631766907 -6.906109588681734 0.921827040241595 0.9814157732998754 1.5940244605803273 0.9893684956981909 0.025837936253558385 0.10704734304152501 0.15314099537632522 0.020755055358819507 0.055860245881118264 1.2413390319723476e-07 6.906109588681734 0.6126086872804519 LKPQLLQGVYAMGFNRPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKPQLLQGVYAMGFNRPSK 19 2 Q9NUU7;F6QDS0;Q9UMR2;H3BQK0;H3BTB3;H3BMQ5;H3BN59 Q9NUU7 DDX19A;DDX19B ATP-dependent RNA helicase DDX19A;ATP-dependent RNA helicase DDX19B 0 47331900.0 11111600.0 8956300.0 27264000.0 False True 16857109.566772178 7357978.289108702 21875258.449764278 1.0 0.43649109949503745 1.297687386032277 24.006853847515693 -6.730135000765094 1.7225221911550117 0.66094292218957 1.2972105444899922 0.5600170824144353 0.23688271790460264 0.3359696690674741 1.9529428478775082 0.10897239503114219 0.2703885408639008 1.8615083954370005e-07 6.730135000765094 0.6362676223004222 LKPQLLQGVYAMGFNRPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKPQLLQGVYAMGFNRPSK 19 2 Q9NUU7;F6QDS0;Q9UMR2;H3BQK0;H3BTB3;H3BMQ5;H3BN59 Q9NUU7 DDX19A;DDX19B ATP-dependent RNA helicase DDX19A;ATP-dependent RNA helicase DDX19B 0 40510200.0 9261600.0 10961100.0 20287500.0 False True 12685863.805329066 10476802.35848947 15496010.334177917 1.0 0.8258643257771997 1.2215179487949703 23.5967184228909 -6.787068242025832 1.5080156991528095 0.9023036198516312 1.2253934224700056 0.7916917640325534 0.07389726358915956 0.239748521927519 1.0771204654905164 0.03857782827205837 0.090517206933898 1.6327953615856372e-07 6.787068242025832 0.3230898026183744 LKPQLLQGVYAMGFNRPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKPQLLQGVYAMGFNRPSK 19 2 Q9NUU7;F6QDS0;Q9UMR2;H3BQK0;H3BTB3;H3BMQ5;H3BN59 Q9NUU7 DDX19A;DDX19B ATP-dependent RNA helicase DDX19A;ATP-dependent RNA helicase DDX19B 0 38192200.0 10962100.0 12489200.0 14740900.0 False True 9115471.8533708 12421918.2006879 17823154.03577916 1.0 1.3627290392097928 1.9552640085426136 23.119885907201184 -6.963801390426609 0.37806377715790784 0.9584020347634645 2.3804801820682413 0.9998862590007043 0.004199088139079313 0.07837014107802238 0.016309078142874238 0.007727343131245756 0.050115649758308144 1.0869225764558757e-07 6.963801390426609 1.4220781473047768 LKPQLLQGVYAMGFNRPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKPQLLQGVYAMGFNRPSK 19 2 Q9NUU7;F6QDS0;Q9UMR2;H3BQK0;H3BTB3;H3BMQ5;H3BN59 Q9NUU7 DDX19A;DDX19B ATP-dependent RNA helicase DDX19A;ATP-dependent RNA helicase DDX19B 0 82311600.0 11111600.0 37374000.0 33826000.0 False True 14384185.242381457 35294104.04561363 27670015.08406961 1.0 2.453674188067555 1.923641458853219 23.777980169608142 -10.595025369309598 7.134768495448747 0.9984666140004003 2.188657823460188 0.8702267029201747 0.2163849555916487 0.005281398713139872 0.000299776000852249 0.20965065649609327 0.06983794411469052 2.540824278978915e-11 10.595025369309598 1.1901912094597877 LKPVHGLIFLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKPVHGLIFLFK 12 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 155865000.0 39768000.0 51018000.0 65079000.0 False True 52136233.113859884 43406313.266606465 58345249.361848705 1.0 0.8325556081470593 1.119092152945323 25.63578301493557 -6.748326579257027 1.6562479999653834 0.9013427343831256 1.1195826926428456 0.6416654489743284 0.07035583950202084 0.3029664583608317 1.6346706635476334 0.03356568171591751 0.0816253851404314 1.7851446831013898e-07 6.748326579257027 0.21823995825971998 LKPVHGLIFLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKPVHGLIFLFK 12 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 225556000.0 49883000.0 63703000.0 111970000.0 False True 48299491.46957369 89139940.10675646 82641697.97200228 1.0 1.845566845417208 1.7110262542632046 25.5255046636621 -10.37105933291028 5.584265945095282 0.999760683217075 1.7782965498402115 0.9780794298361069 0.05492596633663764 0.0001636997441275232 1.8437078103667227e-05 0.05319768129111923 0.01772727940800958 4.255402722440003e-11 10.37105933291028 0.7785358666231365 LKPVHGLIFLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKPVHGLIFLFK 12 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 294856000.0 65000000.0 81776000.0 148080000.0 False True 98609752.13652346 67182433.88119577 118811923.09423041 1.0 0.6812960424865776 1.204869909111397 26.555226995026427 -6.7419311391368435 1.6794841279335133 0.8108006871425693 1.2053171631804995 0.6136536607640415 0.13390154846438238 0.31432695471595096 1.7415633821043208 0.06305214925581851 0.15440602155091782 1.8116273178468915e-07 6.7419311391368435 0.3945164760379303 LKPVHGLIFLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKPVHGLIFLFK 12 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 190775000.0 39768000.0 57808000.0 93199000.0 False True 54471304.28979087 55253851.414507695 71187315.6936561 1.0 1.0143662270422904 1.3068773847406878 25.69899307645846 -6.917118680640558 0.8458283804597871 0.99285165256566 1.3510559215168019 0.9933422301282452 0.0115374659637493 0.0998968786768741 0.11462069492234304 0.009791912345942674 0.02856971582176619 1.210267355844146e-07 6.917118680640558 0.3582042689511419 LKPVHGLIFLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKPVHGLIFLFK 12 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 146768000.0 49883000.0 40638000.0 56247000.0 False True 41479924.69159155 40419075.0279886 68007987.64325587 1.0 0.9744249857855214 1.639539805072063 25.305909939096377 -6.897958954203852 0.974101090511602 0.9707760416944058 1.7065267295686848 0.9855221982140787 0.03702207882664119 0.11292354540036464 0.1860245083546091 0.02861127328365669 0.07370627848610312 1.2648558851712235e-07 6.897958954203852 0.735750687874279 LKPVHGLIFLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKPVHGLIFLFK 12 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 327230000.0 65000000.0 138340000.0 123890000.0 False True 84143781.34155267 130641257.38936664 101343291.21874829 1.0 1.5525955133757716 1.2044061914377264 26.326353317118876 -10.252413253048024 4.471137043511062 0.9998280096563071 1.3785008524106181 0.611738542191933 0.14214769545211087 0.00024381442279173578 4.076659227991603e-05 0.1376960120783837 0.04587797143047392 5.5922521731233103e-11 10.252413253048024 0.378672842754311 LKPYFLTDGTGTVTPANASGINDGAAAVVLMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKPYFLTDGTGTVTPANASGINDGAAAVVLMK 32 1 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 10886000.0 3880100.0 2027700.0 4978200.0 False True 3756928.3493593615 2837371.18431581 3674260.077201227 1.0 0.7552369703296694 0.9779957815346063 21.84112217106121 -10.3766107683049 7.512586302615582 1.000002765904038 0.8666163760047041 0.3234332317624866 0.0909409038601779 4.213081952319706e-06 3.4958206813229386e-07 0.08805497714589924 0.02935105051162658 4.2013535703948477e-11 10.3766107683049 -0.13338638989933393 LKQDK(ub)GSDASWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKQDKGSDASWK 12 2 Q96HR8;Q96HR8-2;D6RIB3 Q96HR8 NAF1 H/ACA ribonucleoprotein complex non-core subunit NAF1 1 8727000.0 751400.0 1521600.0 6454000.0 True False 972702.1123083483 1436921.6224061027 5279438.223632264 1.0 1.4772473547899483 5.4276002455710435 19.891638525182742 -6.929467191545309 0.7511534009598096 0.9387238561702587 6.227690192983155 0.9964324583424322 0.11851952123290702 0.09291553525553399 0.07904270413809057 0.1076365486810365 0.3584921452187744 1.1763398470498792e-07 6.929467191545309 5.288966336812896 up LKSDTAAAAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKSDTAAAAVR 11 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 4189890.0 907890.0 1837700.0 1444300.0 False True 1190252.5820192678 1563522.3232984946 1294857.6907038838 1.0 1.3136054875394374 1.0878847987938434 20.182836327865434 -10.207238851485336 4.513795026620291 0.9999469990422941 1.200745143169265 0.5132862958834902 0.09215008531164054 4.9162936949430775e-05 8.634588110047782e-06 0.08924746655965475 0.029741312145710436 6.205276651240614e-11 10.207238851485336 0.20079814412697095 LKSDTAAAAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKSDTAAAAVR 11 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 3517790.0 907890.0 1418700.0 1191200.0 False True 1243561.467804723 1356017.142986473 909863.0935340832 1.0 1.09043033102358 0.7316591234852892 20.246046389388326 -6.83990805147243 1.28272897292073 1.0481091160829679 0.7198736229398203 0.9243088781956362 0.04191521825443246 0.16890767655881458 0.5398870349507846 0.02562235746503947 0.05903054815987953 1.4457458306535064e-07 6.83990805147243 -0.3282354931431476 LKTDVDVSLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKTDVDVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 6443700.0 2176000.0 2260200.0 2007500.0 False True 2852757.072413978 1922986.970190598 1799783.1572997598 1.0 0.6740801692460211 0.6308925406595518 21.4439254682433 -13.999999999999998 0.2848623712760354 3.728745357448512 0.61850245396207 0.9996159813227372 0.003228805859191718 15.66748996290176 0.1691531936353386 24.978545785918598 0.016698701794659834 1.0000000000000041e-14 13.999999999999998 -3.110242903486442 LKTDVDVSLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKTDVDVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 6155600.0 1280900.0 1815300.0 3059400.0 False True 1240238.5306292118 2540158.7566644405 2258051.359967347 1.0 2.048121142773833 1.820658933101979 20.242186184985833 -10.087283754584963 5.509312738228291 0.9999912512774344 1.9343900379382462 0.957446255793745 0.09286105824487487 9.982179292115502e-06 1.6537086122872677e-06 0.08991317328579611 0.029970777674291262 8.179302032109254e-11 10.087283754584963 0.9343987866608118 LKTDVDVSLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKTDVDVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 29330000.0 2848200.0 19551000.0 6930800.0 False True 4320927.6313114725 16061971.297339784 5560924.342122446 1.0 3.7172507081459063 1.286974653735317 22.04290963759911 -6.619448797249637 2.1193196506173986 2.8037417593006912 1.2963310633368084 0.08072297880676016 1.168694240564422 0.5869239330652292 5.008784396590951 0.45329731439481324 1.2955213202171318 2.401879429630754e-07 6.619448797249637 -1.5074106959638829 LKTDVDVSLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKTDVDVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5944300.0 2176000.0 1267300.0 2501000.0 False True 2980526.0041889185 1211306.4955993197 1910315.3097118377 1.0 0.40640695430837176 0.6409322740439186 21.50713552976619 -10.26065940156067 5.590645839949918 1.0000350361878116 0.5236696141761326 0.846157786396798 0.09574456085257257 4.181454088035815e-05 5.529732601455506e-06 0.09271107211633182 0.030901424139323175 5.487071235631189e-11 10.26065940156067 -0.4763654220116791 LKTDVDVSLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKTDVDVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 15015800.0 2848200.0 7280000.0 4887600.0 False True 3687051.046415539 6874861.600365689 3998106.9510110095 1.0 1.8645962623840702 1.0843644149971483 21.81403595969156 -10.221535465580184 4.3067142162980545 0.9997917855066683 1.4744803387062653 0.33024884259890075 0.31852831791677216 33829426.481908135 80290818.05730714 40353.25322873303 0.10904070522670459 6.004329740379216e-11 10.221535465580184 0.474688553199597 LKVGLQVVAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKVGLQVVAVK 11 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 18676200.0 6214500.0 6576900.0 5884800.0 False True 8147269.681303601 5595652.15655541 5275897.346987609 1.0 0.686813174896658 0.6475663079000278 22.95788523269332 -13.999999999999998 0.29288007275595723 3.7430085514002127 0.6371783926709175 0.9996339088369717 0.003017431074447418 16.139115663127004 0.17168375969557814 26.71782394317129 0.014632243424517367 1.0000000000000041e-14 13.999999999999998 -3.105830158729295 LKVGLQVVAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKVGLQVVAVK 11 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 23127800.0 13256200.0 3626500.0 6245100.0 False True 12835389.187077025 5074580.361947671 4609320.961015914 1.0 0.39535851137703554 0.3591103389102286 23.613623705333556 -13.854439156443629 0.40151018007862893 9.999999998918122 0.3570299614216524 0.9998374550886278 0.003747620103811255 23.87349650881863 0.20875107178214358 186.45198535002783 0.009240031527075473 1.3981727820659069e-14 13.854439156443629 -9.64297003749647 LKVGLQVVAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LKVGLQVVAVK 11 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 1144830000.0 240200000.0 337900000.0 566730000.0 False True 364400960.9721984 277599104.9752501 454715567.09341663 1.0 0.7617957544201681 1.2478440393797663 28.440951522816242 -6.77344979822805 1.5611816187189753 0.8639705482572005 1.2509441206215242 0.7435526493576701 0.1004919716777849 0.2609153864106214 1.2554574924822366 0.05072210314462095 0.12036496332254691 1.6848071688684174e-07 6.77344979822805 0.3869735723643236 LKVGLQVVAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKVGLQVVAVK 11 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 45031700.0 6214500.0 26980000.0 11837200.0 False True 8512168.590547794 25787934.389071006 9041497.15478648 1.0 3.0295375514186618 1.062184924864678 23.021095294216213 -6.638949439162533 2.0486060606473 2.32827574212959 1.0704011705665866 0.1504992325818888 0.8686113148592036 0.5359933729036774 4.298021933679573 0.34547030550330926 0.9616380247344442 2.2964159827473507e-07 6.638949439162533 -1.2578745715630033 LKVGLQVVAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LKVGLQVVAVK 11 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 21810640.0 13256200.0 5094500.0 3459940.0 False True 11023117.64923273 5067054.917320927 4183397.457044948 1.0 0.4596753004512858 0.379511277132757 23.394028980767832 -13.999999999999998 0.2686909929592827 5.141266700672669 0.35256253978169777 0.9995805214348699 0.005643721674853052 14.819216318160338 0.16407871935592092 33.496619530913335 0.033512933577684915 1.0000000000000041e-14 13.999999999999998 -4.788704160890972 LKVGLQVVAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LKVGLQVVAVK 11 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 1095090000.0 240200000.0 443050000.0 411840000.0 False True 310943635.04986036 418393878.0277494 336889345.83525133 1.0 1.345561802416889 1.083441845597613 28.21207784490869 -10.033178293589907 5.346819397705944 0.9999985478593301 1.214501824007587 0.47170876390010175 0.10701002426910948 1.852473043536259e-06 3.349643312080449e-07 0.10361271138659882 0.03453733682245576 9.264494043137911e-11 10.033178293589907 0.21450327614825704 LKVPPAINQFTQALDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LKVPPAINQFTQALDR 16 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 0 9654900.0 1684500.0 5396400.0 2574000.0 False True 2208395.812721202 4591278.155002449 2307667.1715514734 1.0 2.079010532692978 1.0449517963484762 21.074567340114715 -6.636218564794821 2.0581597105827973 1.7076201031485574 1.0492143211730987 0.14028622025301385 0.4621139036839119 0.5429415597227847 4.390845526498651 0.18314395197963562 0.5117212569543677 2.310901503856867e-07 6.636218564794821 -0.6584057819754587 LKVPPAINQFTQALDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LKVPPAINQFTQALDR 16 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 0 22139600.0 9007900.0 4021400.0 9110300.0 False True 8721949.14517516 5627165.991323963 6724039.126858381 1.0 0.6451729880168837 0.7709330810049505 23.05621914788661 -10.341794968248125 5.15612321059319 1.0001179010638854 0.7080530345108883 0.8778337330767803 0.05134134297105516 6.961203893688449e-05 8.886344212060325e-06 0.049731017934441284 0.01657034719155388 4.55202912115586e-11 10.341794968248125 -0.2920648665529971 LKVPPAINQFTQALDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LKVPPAINQFTQALDR 16 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 0 15256700.0 1684500.0 5541500.0 8030700.0 False True 2307305.1719008377 5296658.206710038 6134014.057458166 1.0 2.295603664055617 2.6585187482610952 21.137777401637607 -10.157075262181632 0.29636598054348295 2.0229351724984914e-11 2.786203108455356 0.9989599339730414 0.02295822468219699 1.6054497274326867 0.13659895459715998 1.436706457500486 0.1314141092907525 6.965058008834139e-11 10.157075262181632 2.7862031084351266 LLAAK(ub)NINLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLAAKNINLR 10 1 E9PJD7;Q6ZMK1-2;Q6ZMK1 E9PJD7 CYHR1 Cysteine and histidine-rich protein 1 1 7615900.0 3109200.0 3315700.0 1191000.0 True False 4076191.309535635 2821010.4844973735 1067766.744878712 1.0 0.6920701876523913 0.26195206843722785 21.95879033300685 -7.193169727146784 0.37937652214368844 1.0352352882686657 1.0129324330188883e-11 0.9997665921144799 0.0046242496645025 0.08780253955819205 0.02276986724836638 0.00863511413492522 0.042625663347134045 6.40959033663007e-08 7.193169727146784 -1.0352352882585365 down LLAAK(ub)NINLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLAAKNINLR 10 1 E9PJD7;Q6ZMK1-2;Q6ZMK1 E9PJD7 CYHR1 Cysteine and histidine-rich protein 1 1 11079700.0 5117000.0 3135000.0 2827700.0 True False 4954563.635904193 4386821.848809031 2087040.5408183513 1.0 0.8854103350331576 0.42123599456755645 22.240326569614034 -6.944585420081808 0.6154314148866632 1.0051001557847545 0.2771472271284866 0.9987048667938869 0.009005432227076199 0.08573570106536553 0.0455422805000729 0.009107348209092966 0.0392166213451555 1.1360948206005668e-07 6.944585420081808 -0.7279529286562679 down LLAAK(ub)NINLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLAAKNINLR 10 1 E9PJD7;Q6ZMK1-2;Q6ZMK1 E9PJD7 CYHR1 Cysteine and histidine-rich protein 1 1 19314700.0 6608700.0 0.0 12706000.0 True False 10025881.060686788 0.0 10194653.530762356 1.0 0.0 1.016833679659073 23.257225688525704 -12.07364349432794 18.182143613109126 0.88363223070661 0.5575751558465939 0.0 0.48906311413965664 0.0 0.0 0.0 0.14064241977205338 8.440273225374126e-13 12.07364349432794 -0.3260570748600161 LLAAK(ub)NINLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLAAKNINLR 10 1 E9PJD7;Q6ZMK1-2;Q6ZMK1 E9PJD7 CYHR1 Cysteine and histidine-rich protein 1 1 9805300.0 3109200.0 3546400.0 3149700.0 True False 4258755.262970674 3389708.321623481 2405805.7301077098 1.0 0.7959387455523815 0.5649081906692032 22.02200039452974 -6.969511060742748 0.26960804463782123 1.0577061067219837 0.2961989913384979 0.9999783131464319 0.0008276961197700065 0.07646168705830717 0.009596424097779522 0.004539612922517333 0.0214987314056529 1.0727263269702405e-07 6.969511060742748 -0.7615071153834858 LLAAK(ub)NINLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLAAKNINLR 10 1 E9PJD7;Q6ZMK1-2;Q6ZMK1 E9PJD7 CYHR1 Cysteine and histidine-rich protein 1 1 10578900.0 5117000.0 4012800.0 1449100.0 True False 4255012.221535877 3991182.2499215617 1752100.1101186215 1.0 0.9379954844127135 0.4117732262320479 22.02073184504831 -6.929013673033034 0.7548453402228847 1.008301977836002 0.3064071486622071 0.996340800012429 0.015963356564768726 0.09315324278089059 0.08021324342157246 0.014458956455084299 0.04787490057760901 1.1775688991563217e-07 6.929013673033034 -0.701894829173795 down LLAAK(ub)NINLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLAAKNINLR 10 1 E9PJD7;Q6ZMK1-2;Q6ZMK1 E9PJD7 CYHR1 Cysteine and histidine-rich protein 1 1 17549700.0 6608700.0 0.0 10941000.0 True False 8555092.426952586 0.0 8949850.264140174 1.0 0.0 1.046143024234772 23.028352010618153 -10.5054362755904 5.02734203273045 1.0015563678998733 0.5230715121173722 0.21698637232542506 0.42708610122459084 0.007472066630280805 0.0007350616201955992 0.4147381196290331 0.13784144645328417 3.1229406044158873e-11 10.5054362755904 -0.4784848557825011 LLACIASR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLACIASR 8 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 89040000.0 26491000.0 43321000.0 19228000.0 False True 40188783.75151755 35590029.0814821 15427577.372068215 1.0 0.8855711907464281 0.3838776875522057 25.260289581438872 -6.942773828680617 0.633240331393321 1.0054749669895242 0.2367851555032775 0.9985050237192368 0.010346002834435828 0.08652388051083709 0.04901746556658965 0.010296821465392045 0.042680204553392075 1.1408437600235534e-07 6.942773828680617 -0.7686898114862467 down LLACIASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLACIASR 8 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 119625000.0 45419000.0 27884000.0 46322000.0 False True 62211631.70232363 26651992.679942753 35381697.63153608 1.0 0.4284085138205319 0.5687312269968087 25.890681010329324 -10.188188948622223 8.078179519433789 1.000000138757039 0.4985698704088864 0.9445234907769284 0.05728650776746597 1.431878161998816e-07 1.432428267618921e-08 0.055467438340124735 0.018489140878814796 6.483522933629066e-11 10.188188948622223 -0.5014302683481526 LLACIASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLACIASR 8 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 79840000.0 26491000.0 30897000.0 22452000.0 False True 34293121.71567801 29177554.789354168 18365966.376974255 1.0 0.8508281932237997 0.5355583119333743 25.03141590353132 -6.958951307114075 0.44997010075632743 1.010169901172298 0.36371897142311976 0.9997293036683762 0.003185383806968728 0.0800778850105002 0.022531718396978366 0.004213713771621135 0.026078130759358286 1.0991290663402549e-07 6.958951307114075 -0.6464509297491783 LLACIASRPGQCGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLACIASRPGQCGR 14 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 106957000.0 44338000.0 26924000.0 35695000.0 False True 58127547.36980283 22907044.148930024 32001623.810617685 1.0 0.3940824133383305 0.5505414430618567 25.792718701078755 -10.449101860458512 9.21510201064001 1.0000044237922505 0.4723119282004863 0.9381445811316672 0.0638741314122643 5.8052849813016544e-06 3.470302703966882e-07 0.06184637918394826 0.020615287267763644 3.5554791773639256e-11 10.449101860458512 -0.5276924955917642 LLACIASRPGQCGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLACIASRPGQCGR 14 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 188092000.0 53048000.0 81870000.0 53174000.0 False True 80477694.32828131 67259658.84677047 42664135.59300787 1.0 0.8357552910550298 0.5301361569700801 26.26208563698912 -6.961431716544497 0.4147695399360578 1.0142942002310105 0.340166950556338 0.9998196533423954 0.002614600387542603 0.07919367817663389 0.0192710319410005 0.003942210379093877 0.025478904280443075 1.0928694438683254e-07 6.961431716544497 -0.6741272496746724 LLACIASRPGQCGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLACIASRPGQCGR 14 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 97953000.0 44338000.0 30815000.0 22800000.0 False True 60730956.78939718 29453491.4084219 17415109.580739662 1.0 0.4849831612329231 0.28675836017423173 25.855928762601646 -13.999999999999993 0.13221375465324117 3.4486683018762054 0.01680772350786972 0.9996357120815624 0.00573736781214778 11.933932954939388 0.11328768006748362 7.579546423138685 0.24029044505912595 1.0000000000000164e-14 13.999999999999993 -3.431860578368336 LLACIASRPGQCGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLACIASRPGQCGR 14 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 192570000.0 53048000.0 70707000.0 68815000.0 False True 68671681.73241042 66772093.29355173 56291376.10152685 1.0 0.9723381109805826 0.8197174538534632 26.03321195908157 -6.937634809293207 0.6812105509397508 1.00180337078065 0.7812744180246971 0.9978374181581362 0.0036865433891236847 0.0888624012894824 0.05964847739379938 0.0035272561414286157 0.013278434175707602 1.1544235845932835e-07 6.937634809293207 -0.22052895275595286 LLADPTGAFGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLADPTGAFGK 11 0 P30044-2;P30044;P30044-3;P30044-4 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 16739800.0 6543400.0 2567100.0 7629300.0 False True 6335683.348676074 3592156.4172496474 5630957.455906015 1.0 0.5669722142916559 0.8887687635277225 22.595068802041173 -9.856986644793352 5.765491762560486 1.0000000699425653 0.7278704889090727 0.4881020568440243 0.13137289110497855 1.1816516008237836e-07 2.3341766435137114e-08 0.1272012870697011 0.042400418282406704 1.389995374998547e-10 9.856986644793352 -0.2721295810334926 LLADQAEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLADQAEAR 9 0 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 0 10811870.0 517970.0 5712500.0 4581400.0 False True 679063.6860286153 4860217.2671506 4107360.675891965 1.0 7.157233359914631 6.048564752318214 19.373187358493063 -9.951845327412235 6.412655853009235 0.9999989359609115 6.602899056116617 0.9714721193256379 0.45261206374288493 6.884726582180586e-06 1.1283240886751583e-06 0.4382398245442075 0.14607991543062765 1.117261085886759e-10 9.951845327412235 5.602900120155706 LLADQAEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLADQAEAR 9 0 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 0 8632600.0 2829900.0 1056200.0 4746500.0 False True 2740066.373508946 1477946.1680102388 3503249.258052235 1.0 0.5393833457098237 1.2785271524521329 21.38577940979918 -6.738154721396082 1.6932207423225676 0.7253610299979326 1.2788114601841913 0.5967796897223803 0.19354123592605796 0.32113929889185094 1.80704452418252 0.09044819995134068 0.2224227966132164 1.8274490546564576e-07 6.738154721396082 0.5534504301862587 LLADQAEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLADQAEAR 9 0 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 0 10031070.0 517970.0 4925900.0 4587200.0 False True 709477.5066129286 4708257.4502270175 3503797.836349519 1.0 6.636232165702348 4.938560847512668 19.436397420015954 -9.753011861338498 8.488291103760284 0.9999999999201151 5.78739650522243 0.9138156735578504 0.6930714134204724 4.101143553893239e-09 0.0 0.6710635054776674 0.22368783682582663 1.765989587776906e-10 9.753011861338498 4.787396505302315 LLAEEEEEEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLAEEEEEEKR 11 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 10244400.0 3846400.0 3782500.0 2615500.0 True False 5042667.64859059 3218165.7440695195 2344873.1496475837 1.0 0.6381871597207059 0.46500648328528427 22.265755712816784 -13.999999999999998 0.0975754486798856 2.8002712226275333 0.08188331939769794 0.9998058000084851 0.0031060879154810642 12.099345370798646 0.09252670459207106 4.414296679967975 0.34220338823882906 1.0000000000000041e-14 13.999999999999998 -2.7183879032298353 LLAEEEEEEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLAEEEEEEKR 11 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 25362900.0 7761700.0 11820000.0 5781200.0 True False 11775066.356277728 9710628.649918484 4638543.28601002 1.0 0.8246771912874515 0.3939292693273902 23.489231854122043 -6.955833871410575 0.4906439162517886 1.0093718201117934 0.19094922530483707 0.9995831005450385 0.005199398669865313 0.08122441116256011 0.026896995345712677 0.0062104785013722364 0.03552679068597001 1.1070471764509153e-07 6.955833871410575 -0.8184225948069563 down LLAEEEEEEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLAEEEEEEKR 11 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 9499800.0 3846400.0 2593900.0 3059500.0 True False 5268518.025051587 2479292.9211197635 2336909.1123803956 1.0 0.4705863981732296 0.44356099784958286 22.328965774339675 -13.840758416171079 0.42534144426079723 9.999999999931768 0.4428451026775454 0.9998685496890751 0.0029370933644955223 26.760637573953755 0.21801590571821391 223.18203216434893 0.006472205987019656 1.4429177763318392e-14 13.840758416171079 -9.557154897254224 LLAEEEEEEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLAEEEEEEKR 11 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 12333800.0 4136400.0 6114600.0 2082800.0 True False 3439599.8735901886 6081659.436146934 2518303.8502208707 1.0 1.7681299161692938 0.7321502333910466 21.71380931623933 -6.708127739945585 1.8017843618041711 1.4731357590154692 0.7347113428993657 0.45619004397764706 0.3237834798747923 0.3788830626770744 2.396504815304316 0.14306496196251356 0.36429264260553634 1.9582685991445353e-07 6.708127739945585 -0.7384244161161035 LLAEPVPGIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLAEPVPGIK 10 0 P61088;F8VSD4;F8VV71;Q5JXB2;F8VZ29 P61088 UBE2N;UBE2NL Ubiquitin-conjugating enzyme E2 N;Putative ubiquitin-conjugating enzyme E2 N-like 0 6034100.0 1693200.0 1077300.0 3263600.0 False True 1639450.2928108203 1507471.5080452827 2408765.25409866 1.0 0.9194981480412795 1.4692517758308226 20.64478073003505 -6.869698018075205 1.135765866439564 0.9545580211043969 1.501253615802558 0.9643770742906252 0.04575442707366181 0.13714084755544165 0.33083913284076066 0.03127145696953861 0.07399391985781535 1.349901195384183e-07 6.869698018075205 0.5466955946981611 LLAEPVPGIK(ub)AEPDESNAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLAEPVPGIKAEPDESNAR 19 1 P61088;F8VSD4;F8VV71;Q5JXB2;F8VZ29 P61088 UBE2N;UBE2NL Ubiquitin-conjugating enzyme E2 N;Putative ubiquitin-conjugating enzyme E2 N-like 1 18504600.0 6603400.0 6735800.0 5165400.0 True False 8657121.347416557 5730844.895942749 4630933.958015536 1.0 0.6619804281307594 0.5349276938803094 23.045455951296084 -13.999999999999998 0.1357773538225824 2.609672768177143 0.3693969853265019 0.999620292046748 0.003824502343539826 11.932061451489227 0.11512059227980745 5.102270311864167 0.1476025623351696 1.0000000000000041e-14 13.999999999999998 -2.240275782850641 LLAEPVPGIK(ub)AEPDESNAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLAEPVPGIKAEPDESNAR 19 1 P61088;F8VSD4;F8VV71;Q5JXB2;F8VZ29 P61088 UBE2N;UBE2NL Ubiquitin-conjugating enzyme E2 N;Putative ubiquitin-conjugating enzyme E2 N-like 1 29979200.0 10623000.0 12126000.0 7230200.0 True False 10285778.679736225 16967975.036254622 5336393.718649384 1.0 1.649653911928208 0.518812807936699 23.294147680716065 -6.750913721330048 1.6465580704081781 1.3815794466918097 0.5164187061664619 0.6528837463396926 0.2730008122368592 0.2984396306136819 1.592227541999102 0.1309633754059538 0.3176274143440216 1.7745419834460485e-07 6.750913721330048 -0.8651607405253477 LLAEPVPGIK(ub)AEPDESNAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLAEPVPGIKAEPDESNAR 19 1 P61088;F8VSD4;F8VV71;Q5JXB2;F8VZ29 P61088 UBE2N;UBE2NL Ubiquitin-conjugating enzyme E2 N;Putative ubiquitin-conjugating enzyme E2 N-like 1 85426000.0 19002000.0 25237000.0 41187000.0 True False 28827423.232280288 20733260.17241901 33046371.397096645 1.0 0.7192200289758254 1.1463519000925506 24.78093855008523 -6.729375215930566 1.7253974571072948 0.8309119885433972 1.1460742740967933 0.5564202473815147 0.11803910232174668 0.3374085153543918 1.96753068978129 0.05421951155590658 0.1346430087318473 1.8647678974713207e-07 6.729375215930566 0.3151622855533961 LLAEPVPGIK(ub)AEPDESNAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLAEPVPGIKAEPDESNAR 19 1 P61088;F8VSD4;F8VV71;Q5JXB2;F8VZ29 P61088 UBE2N;UBE2NL Ubiquitin-conjugating enzyme E2 N;Putative ubiquitin-conjugating enzyme E2 N-like 1 22067200.0 6603400.0 6382200.0 9081600.0 True False 9044855.430175122 6100213.300886914 6936713.121423054 1.0 0.674440111064197 0.7669236036964218 23.108666012818976 -10.16481236131592 7.496631374681308 1.0000001531106109 0.7206818573803097 0.9240242822297137 0.037756227763233036 9.662537284484292e-08 1.0790836637126326e-08 0.03655733021864647 0.012185770111884642 6.842071979117962e-11 10.16481236131592 -0.2793182957303012 LLAETHYQLGLAYGYNSQYDEAVAQFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLAETHYQLGLAYGYNSQYDEAVAQFSK 28 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 0 179610000.0 41485000.0 79996000.0 58129000.0 False True 62935777.95974875 65720088.78839917 46639777.67115418 1.0 1.0442405086409061 0.7410693755304518 25.90737706304426 -6.869837420110403 1.1350208193566145 1.024994032240553 0.7233739444949201 0.9645172957204461 0.025187519004246994 0.13700741561208454 0.3299966729307035 0.017224506906078515 0.040766317507879075 1.3494679668176107e-07 6.869837420110403 -0.301620087745633 LLAETHYQLGLAYGYNSQYDEAVAQFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLAETHYQLGLAYGYNSQYDEAVAQFSK 28 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 0 104267000.0 41485000.0 30113000.0 32669000.0 False True 53703150.29160473 28437185.07854558 26723577.212247107 1.0 0.52952545472907 0.49761656564167583 25.67850338513671 -13.999999999999998 0.382256247421923 8.080890088878427 0.494923207028444 0.9998111306033445 0.003156406609719024 24.32310729287549 0.20185743407445003 141.86198327921164 0.008590676893728558 1.0000000000000041e-14 13.999999999999998 -7.585966881849982 LLAEVTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLAEVTLK 8 0 K7ER00;Q9Y285;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 6311100.0 2531600.0 2299600.0 1479900.0 False True 3318952.116049275 1956508.6437705918 1326774.144203196 1.0 0.5894958936917499 0.399756940688414 21.662296384508213 -13.999999999999998 0.10344182462159739 3.0084296487737348 0.016361142116722804 0.9997763756788993 0.0037461700142097055 12.055154378647497 0.09646031181300643 5.125759023369483 0.3413296876417855 1.0000000000000041e-14 13.999999999999998 -2.992068506657012 LLAEVTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLAEVTLK 8 0 K7ER00;Q9Y285;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 7271700.0 3315800.0 1825000.0 2130900.0 False True 3210541.7439771537 2553732.0172492717 1572753.3643702755 1.0 0.7954209042881842 0.48987164465956473 21.614385326299395 -6.96532877808052 0.35236492828192945 1.0287356904732443 0.24620899108991187 0.9999197616474097 0.0018776305023911327 0.07784957728063711 0.01446760226287559 0.004169594008919843 0.026222125824353737 1.08310664905014e-07 6.96532877808052 -0.7825266993833324 down LLAEVTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLAEVTLK 8 0 K7ER00;Q9Y285;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 30119500.0 6713500.0 13185000.0 10221000.0 False True 10184870.322593082 10832033.735124813 8200814.869976566 1.0 1.0635416448156567 0.8051958061542238 23.279924275723694 -6.841666534735386 1.2747758652808987 1.0337971901739802 0.7964221289593089 0.9272582809547139 0.02964440848916579 0.16686321546680166 0.5260345963280475 0.018230181254995672 0.042016034425961975 1.439903758299851e-07 6.841666534735386 -0.23737506121467133 LLAEVTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLAEVTLK 8 0 K7ER00;Q9Y285;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 8420900.0 2531600.0 2294700.0 3594600.0 False True 3467600.933917583 2193312.5664418535 2745629.5131108263 1.0 0.6325158541135586 0.7917951244778629 21.725506446031105 -10.136451586200605 4.8872112849826355 1.0000168903736932 0.712155489295915 0.8132404388808505 0.06502548983730964 17136355.265346386 35542117.984916426 2117.220980921365 0.022259956506809685 7.303792287422589e-11 10.136451586200605 -0.28786140107777825 LLAEVTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLAEVTLK 8 0 K7ER00;Q9Y285;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 5611160.0 3315800.0 1435000.0 860360.0 False True 2757234.614846324 1427269.3701748024 1040257.2981448191 1.0 0.517645238634998 0.37728283713818034 21.39479060173367 -13.999999999999998 0.17307916964635442 3.452758405178298 0.25744026827287 0.999508141727118 0.005914765060582428 12.122960397244757 0.13179819199805815 9.98673230968882 0.11130533694731334 1.0000000000000041e-14 13.999999999999998 -3.1953181369054278 LLAEVTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLAEVTLK 8 0 K7ER00;Q9Y285;K7EPH2;K7ER16 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 21751800.0 6713500.0 7830300.0 7208000.0 False True 8690758.092869446 7394536.921613105 5896217.960325593 1.0 0.8508506211535379 0.678446908465131 23.051050597816143 -6.969225799427886 0.2760532993184969 1.0398321758900635 0.4842399960589095 0.9999756959257936 0.0006477054988769927 0.07655473892618926 0.00992600998475656 0.0032586747040762314 0.015904888459737993 1.0734311663268736e-07 6.969225799427886 -0.555592179831154 LLAEYTGAQQKLKQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLAEYTGAQQKLKQR 15 2 Q16280 Q16280 CNGA2 Cyclic nucleotide-gated olfactory channel 0 14021300.0 4057100.0 6028400.0 3935800.0 False True 5318897.389012282 5128986.218519152 3528561.170859476 1.0 0.9642950114274725 0.6634008729231622 22.34269577439792 -6.929140919375895 0.7538109118759128 1.0047245613287152 0.6029589847387351 0.9963666676621264 0.009099673362475578 0.09308645428231728 0.07988373086864373 0.008248255336804955 0.027355500945658147 1.177223927270079e-07 6.929140919375895 -0.40176557658998013 LLAEYTGAQQKLKQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLAEYTGAQQKLKQR 15 2 Q16280 Q16280 CNGA2 Cyclic nucleotide-gated olfactory channel 0 25377200.0 8856700.0 8366700.0 8153800.0 False True 8575548.906412471 11707566.941764105 6018075.171243301 1.0 1.3652265376283528 0.7017714244207985 23.031797588039876 -6.757250314381499 1.6226740943571265 1.212871860274321 0.6996615209112622 0.6796526347529612 0.15356186470827185 0.28758610582195804 1.4917590269676382 0.07468835962935368 0.17998909107749625 1.7488384197987548e-07 6.757250314381499 -0.5132103393630587 LLAEYTGAQQKLKQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLAEYTGAQQKLKQR 15 2 Q16280 Q16280 CNGA2 Cyclic nucleotide-gated olfactory channel 0 14168800.0 4057100.0 5365200.0 4746500.0 False True 5557119.509004979 5128147.72365618 3625474.457236003 1.0 0.9228068094174192 0.6524017436301557 22.405905835920812 -6.947925417164805 0.5811813279658347 1.003218171096638 0.5585887349976593 0.999028195163512 0.004645973886246564 0.0843298157839026 0.03949486365513332 0.004861566471250344 0.02259576850771787 1.1273910501648372e-07 6.947925417164805 -0.44462943609897865 LLAEYTGAQQKLKQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLAEYTGAQQKLKQR 15 2 Q16280 Q16280 CNGA2 Cyclic nucleotide-gated olfactory channel 0 20797100.0 8856700.0 7155100.0 4785300.0 False True 7364738.468336284 7116554.056123847 5785884.105272689 1.0 0.9663009877024863 0.7856197650667882 22.812202863474152 -6.938260248156711 0.6755542918412092 1.0021020801099567 0.7392921930642627 0.9979270341772557 0.0042856146505700615 0.08856937591935224 0.05829161147845753 0.004118657923123234 0.01567381662289435 1.15276226548068e-07 6.938260248156711 -0.26280988704569397 LLAEYTGAQQKLKQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLAEYTGAQQKLKQR 15 2 Q16280 Q16280 CNGA2 Cyclic nucleotide-gated olfactory channel 0 16480900.0 4152000.0 9211600.0 3117300.0 False True 5374845.848155793 8698966.362352813 2549983.3861990813 1.0 1.6184587629313287 0.4744291200600715 22.357791947786215 -6.759891766540046 1.613005671598836 1.3592827706315245 0.470289248017133 0.6904931951218602 0.26011979532624613 0.28309073257059053 1.4516513311223287 0.12724363086364288 0.30580353771759294 1.738233971797598e-07 6.759891766540046 -0.8889935226143915 LLAGEEDALNQTSEQTK(ub)SLSSNFILVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLAGEEDALNQTSEQTKSLSSNFILVK 27 1 Q92681 Q92681 RSC1A1 Regulatory solute carrier protein family 1 member 1 1 30393100.0 11904000.0 9501700.0 8987400.0 True False 11526114.035920173 13295778.36071093 6633330.32377935 1.0 1.1535352087681716 0.5755044851289107 23.458402862712024 -6.836056871671104 1.3005777754583348 1.081762627201381 0.5579286903372961 0.9174628180382373 0.07023440407303601 0.1734526786885176 0.5716180205664189 0.04237060912700315 0.0975348672764501 1.4586232383391216e-07 6.836056871671104 -0.5238339368640849 LLAGEEDALNQTSEQTK(ub)SLSSNFILVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLAGEEDALNQTSEQTKSLSSNFILVK 27 1 Q92681 Q92681 RSC1A1 Regulatory solute carrier protein family 1 member 1 1 30211400.0 11904000.0 13614000.0 4693400.0 True False 9898703.43661581 13540658.679832585 5674768.240170271 1.0 1.3679224523228968 0.5732839938591365 23.2388081381463 -6.780795953989241 1.532603744150494 1.2081138938245657 0.5668141930191382 0.7702311342452689 0.15564508791444684 0.24935087568021605 1.156881731107021 0.07998041810160705 0.18860810272774106 1.656548082118622e-07 6.780795953989241 -0.6412997008054275 LLAHVTLELQHYHQLLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLAHVTLELQHYHQLLEK 18 0 P56192;H0YIP0 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 161279100.0 47899100.0 54897000.0 58483000.0 False True 72666436.59326997 45100201.43778127 46923809.41599049 1.0 0.6206469389742751 0.6457425410665637 26.114785825587184 -10.68102081305373 6.664023904667687 1.0027463167626682 0.6331947400204199 0.9965016476240554 0.010245236652338148 0.00042041627831721363 2.0123564231949357e-05 0.009976452598489114 0.003306635911038287 2.0843909887099683e-11 10.68102081305373 -0.36955157674224837 LLAHVTLELQHYHQLLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLAHVTLELQHYHQLLEK 18 0 P56192;H0YIP0 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 6618970.0 4154400.0 1872300.0 592270.0 False True 3454567.6711253934 1862213.5482775464 716110.9186529274 1.0 0.5390583498602862 0.20729393279467592 21.7200737422387 -8.11572514698368 0.2932765639327651 1.1415338466486546 1.392196577349975e-14 0.9991543976027597 0.009452207400492746 0.09074202131829706 0.06185908250704665 0.07145004873293329 0.09396182642942622 7.66081285271434e-09 8.11572514698368 -1.1415338466486407 down LLAHVTLELQHYHQLLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLAHVTLELQHYHQLLEK 18 0 P56192;H0YIP0 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 132735200.0 47899100.0 52109200.0 32726900.0 False True 62006329.18241791 49209277.21233182 26770940.00635126 1.0 0.7936170042829316 0.431745280834045 25.885912147679633 -6.962534720113862 0.39810984289458096 1.0203120468465257 0.1918773351546912 0.9998529513123403 0.0028480650851886993 0.07880788624899117 0.017875156726975656 0.0046576753824371115 0.030340549438677915 1.090097339961388e-07 6.962534720113862 -0.8284347116918345 down LLAK(ub)LLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLAKLLK 7 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 16627600.0 4167900.0 7268900.0 5190800.0 True False 5464157.26200101 6184408.453950273 4653705.809669544 1.0 1.1318137742773353 0.8516786004737585 22.3815675752516 -6.7787193737314215 1.5405922888626247 1.0747581238532564 0.8495368602648403 0.7629498374003767 0.05571387197257401 0.25255356828329995 1.1838347104656297 0.028484641368458727 0.0672916183164982 1.6644878381778926e-07 6.7787193737314215 -0.2252212635884161 LLAK(ub)LLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLAKLLK 7 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 18978600.0 5701300.0 4335300.0 8942000.0 True False 5520315.352233836 6066407.898290836 6599821.945750157 1.0 1.098924157627339 1.195551617006715 22.396319253738625 -6.971413500942366 0.22184670570467466 0.9564658396578375 1.3407442984855436 0.9999914017862767 0.00023402797268683634 0.07584669328111784 0.007367200217481406 0.0026390642186004186 0.009755750584064641 1.0680374939227251e-07 6.971413500942366 0.38427845882770606 LLAK(ub)LLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLAKLLK 7 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 32663400.0 6711400.0 13020000.0 12932000.0 True False 10181684.469062492 10696479.274275677 10375984.531703059 1.0 1.050560868074179 1.0190832924778759 23.279472926423423 -10.493892082998093 6.5376198545877555 0.9999828959461277 1.0348220802759986 0.6200203049381574 0.012850666425137736 3.205331800961401e-06 2.4814149040271313e-07 0.012448715464224783 0.0041475347543521 3.207066143209341e-11 10.493892082998093 0.03483918432987099 LLAK(ub)LLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLAKLLK 7 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 14716400.0 4167900.0 5807700.0 4740800.0 True False 5708885.263262394 5551096.610504358 3621120.6798408153 1.0 0.9723608646028619 0.6342955783580582 22.444777636774493 -6.923120499621708 0.8012474567430131 1.006654086456532 0.5756655131059273 0.9950046290325473 0.01175115575461833 0.09637044776540338 0.09635530315400577 0.010295865068476955 0.03182417713464906 1.1936568657244036e-07 6.923120499621708 -0.4309885733506048 LLAK(ub)LLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLAKLLK 7 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 14906100.0 5701300.0 6613200.0 2591600.0 True False 4740883.560414788 6577573.378982573 3133491.5777954734 1.0 1.387415087327538 0.6609509678658546 22.1767245291729 -6.761799069102062 1.605430083731816 1.2245211185381033 0.6580313581613713 0.698405829764062 0.16299362413163584 0.2798869762863491 1.4221213355200388 0.08008582379441162 0.19213915757234956 1.7306168620662515e-07 6.761799069102062 -0.566489760376732 LLAK(ub)LLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLAKLLK 7 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 30313800.0 6711400.0 14478000.0 9124400.0 True False 8688039.601472236 13672286.572815169 7463852.824250127 1.0 1.5736906367805144 0.8590951660700691 23.050599248515873 -6.692980303466863 1.8559214853780657 1.3586585937245341 0.8614782468672688 0.3843869683859461 0.24248582678902966 0.4102830082945416 2.74222269898582 0.10443579407692807 0.27093128513680836 2.0277746829866614e-07 6.692980303466863 -0.4971803468572653 LLALNPDAVELFKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLALNPDAVELFKK 14 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 28777000.0 8703700.0 10691000.0 9382300.0 True False 11410634.9867507 9095944.473191604 8411509.597376615 1.0 0.7971462134888403 0.7371640234871698 23.443875742143664 -13.999999999990864 0.1707869856355559 2.0251220065144304 0.6846937318437262 0.9995121963064472 0.002483870801926195 12.09931177581345 0.1308831839438596 4.109457231006514 0.04855471094664908 1.000000000021036e-14 13.999999999990864 -1.3404282746707041 LLALNPDAVELFKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLALNPDAVELFKK 14 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 90405000.0 36955000.0 22358000.0 31092000.0 True False 35781883.753144324 31285665.995429758 22948072.459993724 1.0 0.8743437380565672 0.6413321506019696 25.092726004921133 -6.961496352450229 0.4138079813883014 1.0110125103435026 0.49596225650356507 0.9998217258278393 0.0019840336660774745 0.0791708937653682 0.019188023501356732 0.0030043874929313093 0.01943142218216861 1.0927068045694266e-07 6.961496352450229 -0.5150502538399375 LLALNPDAVELFKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLALNPDAVELFKK 14 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 83145000.0 36955000.0 28180000.0 18010000.0 True False 30729719.884084117 28028188.746707957 21775807.73116856 1.0 0.912087349069024 0.7086236976226696 24.87313128035541 -6.957093089191612 0.4746343003204107 1.005139008304867 0.6071656627489477 0.9996467170339199 0.0022936842789629893 0.08075639135989063 0.025096002216253372 0.0028382994461216824 0.01678805938728601 1.1038419906648179e-07 6.957093089191612 -0.39797334555591934 LLALQLQK(ub)EVDKEQMVPNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLALQLQKEVDKEQMVPNR 19 2 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 8160400.0 2611800.0 2966400.0 2582200.0 True False 3424095.092707175 2523824.6829366363 2315018.714211427 1.0 0.7370778598736981 0.676096501858865 21.707291337614652 -13.999999999999998 0.20530044366134356 2.491970238646596 0.6384984305919215 0.9994879167982642 0.0031802819601261284 12.640743638827095 0.1436442628637153 7.590680737966513 0.03734943144365266 1.0000000000000041e-14 13.999999999999998 -1.8534718080546746 LLALQLQK(ub)EVDKEQMVPNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLALQLQKEVDKEQMVPNR 19 2 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 33409400.0 7820400.0 12130000.0 13459000.0 True False 11864118.54782258 9965306.727877429 10798822.750710739 1.0 0.8399534013174843 0.9102086014382118 23.500101582786076 -10.128208295148596 4.455586096088622 1.000015117258109 0.8750810013736848 0.8082601400757852 0.028681565370456196 4.64565164361224e-06 9.089829608792584e-07 0.027774429887272252 0.009256935414992435 7.443748732070695e-11 10.128208295148596 -0.12493411588442427 LLALQLQK(ub)EVDKEQMVPNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLALQLQKEVDKEQMVPNR 19 2 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 35858500.0 7820400.0 19139000.0 8899100.0 True False 10123661.963130435 18073897.82546688 7279555.112476906 1.0 1.7853122606513894 0.7190634316898827 23.271227904878526 -6.709360199651699 1.7975333544820244 1.4831075075119966 0.7216197359521664 0.4620510117916953 0.33095924375233515 0.3763576703584794 2.370113437620531 0.14654373520223654 0.3725724342128138 1.952719217490951e-07 6.709360199651699 -0.7614877715598302 LLANLK(ub)EMEEPFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLANLKEMEEPFEK 14 1 P30566;A0A0A6YY92;A0A1B0GTJ7;A0A1B0GWJ0;A0A096LNY6;P30566-2;A0A1B0GWF8;A0A1B0GTG9;A0A096LPA2 P30566 ADSL Adenylosuccinate lyase 1 8410300.0 2155200.0 1620900.0 4634200.0 True False 2086784.3556968379 2268133.822881833 3420363.996980024 1.0 1.0869037889276476 1.6390596314576382 20.992850092178934 -6.934635037400523 0.707710623063227 0.992871645940542 1.7670675897957968 0.9973734084431989 0.014504076127712496 0.0903013808541108 0.06640626819772695 0.013599380408527878 0.04875020845198375 1.1624250560481622e-07 6.934635037400523 0.7741959438552548 LLANMVYQYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLANMVYQYK 10 0 P28074;P28074-3;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 0 30080800.0 11834000.0 12432000.0 5814800.0 False True 15514488.600619014 10577194.059556454 5213140.275500205 1.0 0.6817623404702127 0.3360175388115729 23.887112806742973 -7.1843311629508895 0.2861851740491888 1.0806320335994102 4.021808552747337e-11 0.9999420941870953 0.002063310336716477 0.08755639520772697 0.014502757802241632 0.009660004277065268 0.038410221890344584 6.541371840450928e-08 7.1843311629508895 -1.0806320335591921 down LLANMVYQYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLANMVYQYK 10 0 P28074;P28074-3;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 0 25364800.0 10438000.0 3821800.0 11105000.0 False True 10106651.403472336 5347864.670423708 8196267.357141067 1.0 0.5291430818110878 0.8109775463636829 23.26880173822451 -10.302310189998403 5.853801250440252 1.0000271829805534 0.6700603140873849 0.6463108176885881 0.11505843834739962 4.082162439346227e-05 4.8654515208898765e-06 0.1114140160902261 0.037134951296675316 4.985282919887319e-11 10.302310189998403 -0.3299668688931685 LLANMVYQYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLANMVYQYK 10 0 P28074;P28074-3;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 0 23420800.0 11834000.0 5772000.0 5814800.0 False True 16209349.60182519 5516973.95454848 4441463.99956514 1.0 0.3403575152655886 0.27400630553770194 23.950322868265864 -13.999999999999998 0.32463048606664036 7.952886857982701 0.261503735982854 0.9997035901590875 0.005642189505007556 18.3797591969325 0.18192044726113366 87.0073424605845 0.021698356401403017 1.0000000000000041e-14 13.999999999999998 -7.691383121999848 LLANMVYQYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLANMVYQYK 10 0 P28074;P28074-3;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 0 18056900.0 10438000.0 4943700.0 2675200.0 False True 8679659.48180408 4917067.306852381 3234571.951272751 1.0 0.5665046327174993 0.3726611577393864 23.049207013658787 -13.999999999999975 0.10885817021959986 3.0959859971899895 0.011145126378868053 0.99974886499038 0.004156176291750093 12.019487177700316 0.09993081540453347 5.549003653557981 0.32119968988830944 1.0000000000000573e-14 13.999999999999975 -3.0848408708111212 LLANMVYQYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLANMVYQYK 10 0 P28074;P28074-3;H0YJM8;P28074-2 P28074 PSMB5 Proteasome subunit beta type-5 0 34734600.0 6959600.0 16968000.0 10807000.0 False True 9009339.394225677 16023715.883929228 8840236.889184052 1.0 1.7785672381483653 0.9812303102766883 23.102989894273662 -10.33123867739403 3.89368665373363 0.9990553207968633 1.3798987742472346 0.23235465732357619 0.32551143785796444 41985326.6280449 55703971.14073352 274840.6471322684 0.11143122468854641 4.664029864411923e-11 10.33123867739403 0.3808434534503713 LLASANLEEVTMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLASANLEEVTMK 13 0 H0Y993;P35659;A0A494C028;P35659-2;B4DFG0;A0A494C198 H0Y993 DEK Protein DEK 0 13881600.0 1857700.0 5751300.0 6272600.0 False True 2435462.689992389 4893228.458391809 5623571.523027884 1.0 2.009157635014766 2.309036203320141 21.215764451342505 -10.403339668080301 0.2653433113176914 9.25862302099244e-10 2.445145503149056 0.9990988865338862 0.016808905229991282 1.9769584670225313 0.12858082350125422 1.4729040789808645 0.1256500802599552 3.9505751893120456e-11 10.403339668080301 2.4451455022231934 LLASANLEEVTMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLASANLEEVTMK 13 0 H0Y993;P35659;A0A494C028;P35659-2;B4DFG0;A0A494C198 H0Y993 DEK Protein DEK 0 8721500.0 1857700.0 2940200.0 3923600.0 False True 2544541.892454846 2810292.2420588024 2996926.4890785175 1.0 1.1044393689850294 1.1777862639892456 21.278974512865396 -6.974917804435798 0.07622739475273842 0.7233627969848034 1.5607002303917539 0.9999999114526833 2.0925796737924656e-05 0.07473606210925204 0.0022068582735143717 0.009374318084370234 0.014777285579150104 1.05945422092585e-07 6.974917804435798 0.8373374334069504 LLASLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLASLVK 7 0 Q13263;Q13263-2;M0R3C0 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 6047660.0 886560.0 3151500.0 2009600.0 False True 1214345.1903831442 3012256.3093831455 1534973.8690111602 1.0 2.4805601679311082 1.2640342146262817 20.21174715044472 -6.597654225687034 2.199817541202487 1.9972377857670958 1.2679079724078006 0.013758944676438345 0.6403320250555397 0.6474336911124495 5.917751960573031 0.24195317432184926 0.7125039307249207 2.525490704248162e-07 6.597654225687034 -0.7293298133592951 LLATEK(ub)EASAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLATEKEASAR 11 1 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 15102300.0 4554700.0 4155900.0 6391700.0 True False 5971255.807777544 3535855.919571323 5730348.197515753 1.0 0.5921461135471504 0.959655453054279 22.509602944219004 -10.334189656192285 8.270440660953945 1.0000006980642524 0.7759007833007148 0.33144924601538384 0.1500350595832887 1.931221815590205e-06 1.5534357261334887e-07 0.14527127525913885 0.04842360725944289 4.632445768730926e-11 10.334189656192285 -0.22409991476353763 LLATEK(ub)EASAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLATEKEASAR 11 1 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 36657500.0 6205800.0 9924700.0 20527000.0 True False 6008800.275883177 13887684.46662678 15150362.903199892 1.0 2.311224176041624 2.521362369790712 22.51864553882758 -10.499510645791728 0.377460105073944 1.2367125639492032e-21 2.548547517385543 0.9992156606370911 0.01885188982081109 1.9827162338722402 0.1791183790264625 1.967388262487486 0.05711526510603648 3.1658428586773926e-11 10.499510645791728 2.548547517385543 LLATEK(ub)EASAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLATEKEASAR 11 1 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 19514400.0 4554700.0 3794700.0 11165000.0 True False 6238695.676139364 3627037.6066051833 8528056.950392911 1.0 0.5813775498742825 1.3669615241867756 22.572813005741896 -6.761913219609103 1.6051199994050338 0.7574307437576842 1.3701253002649425 0.698849158651808 0.17612533214706816 0.2796815801524891 1.4205727337712166 0.08655620632940135 0.20762949803476882 1.7301620443318447e-07 6.761913219609103 0.6126945565072583 LLATEK(ub)EASAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLATEKEASAR 11 1 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 36892800.0 6205800.0 16451000.0 14236000.0 True False 5160397.663554296 16362375.197732154 17212681.78017301 1.0 3.1707585857757987 3.335533984471564 22.299050814261857 -10.320150856830331 0.5379220734963402 1.6781426677169549e-21 3.3241702228678274 0.9996102806777241 0.021010111140171494 1.6558359771808684 0.255105845068353 2.4634988254250847 0.03128321327275146 4.7846386391641646e-11 10.320150856830331 3.3241702228678274 LLATEK(ub)EASAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLATEKEASAR 11 1 Q07820;Q07820-2 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 23360200.0 6432600.0 9711100.0 7216500.0 True False 8327127.50550264 9170668.748257041 5903171.047542967 1.0 1.1013003874621807 0.7089084493592898 22.98938748409189 -6.838169667730023 1.2907617194588519 1.0539108653928568 0.6964546746621276 0.9212769618236357 0.04666604420518795 0.1709485558035993 0.554022094014325 0.028356743437439786 0.06530377805839173 1.4515444255741737e-07 6.838169667730023 -0.3574561907307292 LLAVSLLDCTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLAVSLLDCTVK 12 0 Q9UNX4 Q9UNX4 WDR3 WD repeat-containing protein 3 0 4524800.0 1047700.0 1431700.0 2045400.0 False True 1435063.0030279078 1368442.760001223 1562318.6463353059 1.0 0.9535767817258758 1.088675997526865 20.45268264570991 -6.813919471600413 1.3978150843084212 0.9748144378759928 1.0912617537197606 0.8698673272910991 0.02021796616298996 0.20149586734728592 0.7751410263413206 0.011370265178598984 0.026260448540839147 1.5349015632229526e-07 6.813919471600413 0.11644731584376788 LLCGLLAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLCGLLAER 9 0 P14174 P14174 MIF Macrophage migration inhibitory factor 0 207076000.0 0.0 96976000.0 110100000.0 False True 0.0 82507558.80948739 98707908.15377513 0.0 LLCGLLAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLCGLLAER 9 0 P14174 P14174 MIF Macrophage migration inhibitory factor 0 169829000.0 98072000.0 38219000.0 33538000.0 False True 94958758.0418988 53480046.00945203 24753391.681566615 1.0 0.5631923491022802 0.2606751835427822 26.50079773042018 -8.173349638091384 0.24727787148249422 1.1992189469803745 9.323614667559213e-16 0.9995352544917265 0.00654247628057924 0.08811231462694344 0.052117157997130584 0.0879176917545684 0.10286787119878328 6.708885222525307e-09 8.173349638091384 -1.1992189469803736 down LLCGLLAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLCGLLAER 9 0 P14174 P14174 MIF Macrophage migration inhibitory factor 0 343311000.0 38553000.0 271020000.0 33738000.0 False True 58487719.60183673 222654363.51107514 27069669.512109287 1.0 3.8068566363473497 0.46282655053727206 25.80163040464493 -6.684088538914353 1.8873230145134194 2.7693819383516525 0.47511218976556935 0.3429194671005228 1.1885660777423985 0.42952125756771076 2.9614000632116313 0.504679248291252 1.3241446968979869 2.069719355435923e-07 6.684088538914353 -2.2942697485860832 LLCGLLAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLCGLLAER 9 0 P14174 P14174 MIF Macrophage migration inhibitory factor 0 288420000.0 0.0 128360000.0 160060000.0 False True 0.0 122688630.7702428 122257124.53917517 0.0 LLCGLLAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLCGLLAER 9 0 P14174 P14174 MIF Macrophage migration inhibitory factor 0 147168000.0 98072000.0 20645000.0 28451000.0 False True 81551213.3262589 20533781.28728833 34399972.557439096 1.0 0.25179001574310855 0.4218204874502162 26.281203005854458 -10.516927323151323 9.31841352029794 1.0000209011467445 0.3368052516252683 0.9530177699361564 0.06941464940119094 3.014245472657319e-05 1.5625965412698282e-06 0.06721254995186884 0.02240348175946993 3.0413939440320015e-11 10.516927323151323 -0.6632156495214762 LLCGLLAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLCGLLAER 9 0 P14174 P14174 MIF Macrophage migration inhibitory factor 0 139249000.0 38553000.0 56670000.0 44026000.0 False True 49907618.493244305 53516264.68306633 36013719.74490773 1.0 1.0723065195008354 0.721607658954568 25.572756726737378 -6.852945432676693 1.220709500044364 1.0387076481749271 0.7067645758072287 0.9444899686544547 0.03562074228358538 0.15425011522012697 0.4408227689640402 0.022814310696030272 0.052905551454872767 1.4029899734332106e-07 6.852945432676693 -0.3319430723676984 LLCNFMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLCNFMR 7 0 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 3722880.0 768580.0 1580200.0 1374100.0 False True 1007615.8229393084 1344440.3195713558 1231921.313297934 1.0 1.3342786893217886 1.222610131016309 19.942514251825397 -10.108524114084743 4.352217600500959 0.9999639718185866 1.2784444101864607 0.892357237829956 0.04558849810417631 31760316.475104176 0.7043285046537537 11685.603763822093 0.01560615547255309 7.788895657185528e-11 10.108524114084743 0.27848043836787406 LLCNFMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLCNFMR 7 0 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 4308580.0 768580.0 2484500.0 1055500.0 False True 1052744.7960935286 2374726.574857187 806212.6387048569 1.0 2.255747626271059 0.7658196380514151 20.00572431334829 -6.683214881542065 1.8901809903573388 1.792197758950793 0.7712969864141427 0.33905924244440544 0.531841444302757 0.4314002214751256 2.982573233177063 0.22553321936376836 0.5924518351715695 2.0738871393844744e-07 6.683214881542065 -1.0209007725366503 LLCQCLGFGSGHFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLCQCLGFGSGHFR 14 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 176096000.0 49286000.0 56098000.0 70712000.0 False True 67508366.10406941 53619404.86872147 54011281.95935364 1.0 0.7942631108278191 0.80006797788723 26.008562966211137 -10.21294497145547 5.298496768685938 1.0000137067094024 0.79716554435748 0.9993860991423631 0.0023698270535303903 3.837353022936041e-07 5.70016545317127e-08 0.0022947301469846116 0.0007648583926204218 6.124279862766644e-11 10.21294497145547 -0.20284816235192238 LLDAVDTYIPVPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLDAVDTYIPVPAR 14 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 24845800.0 1931800.0 13702000.0 9212000.0 False True 2532608.507577812 11657715.009977689 8258830.607743657 1.0 4.6030466118615125 3.260997735351686 21.272192650785286 -10.477546440904852 10.930792724885519 0.9999942939484948 3.9320221736065992 0.8642059664042148 0.5478891595540847 7.618763720004049e-05 3.6405054516406103e-06 0.5304924143073476 0.17683046587671233 3.330071505730571e-11 10.477546440904852 2.9320278796581043 LLDAVDTYIPVPAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLDAVDTYIPVPAR 14 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 25458300.0 9043400.0 3796900.0 12618000.0 False True 8756322.217106892 5313021.970571927 9312967.268114002 1.0 0.6067641001369364 1.0635706449814757 23.061893613435206 -6.6789235451844 1.9058517263479606 0.7509534673738129 1.0618119781658937 0.31915537362455715 0.16670228177494978 0.4409112189457854 3.0954608606440446 0.07021216839144143 0.1854261850379256 2.094481143646605e-07 6.6789235451844 0.3108585107920808 LLDAVDTYIPVPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLDAVDTYIPVPAR 14 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 29260800.0 1931800.0 13393000.0 13936000.0 False True 2646038.664932053 12801252.975271594 10644603.820929294 1.0 4.837893393217032 4.022845154155234 21.335402712308177 -10.45608408242082 5.908155798977116 0.9979020243106695 4.430369273686123 0.9593802795479143 0.3327420502425653 0.009193295016219627 0.0008463501616602188 0.3221085415473773 0.10739203493102993 3.498774217775207e-11 10.45608408242082 3.4324672493754536 LLDDPSKQK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLDDPSKQK 9 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925;Q6STE5-2;Q6STE5 J3KMX2 SMARCD2;SMARCD3 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 1 5810200.0 2177700.0 2274000.0 1358500.0 True False 2108570.105512713 3182020.058753342 1002668.0958735828 1.0 1.5090890506481938 0.4755203980423393 21.007833558308615 -6.772774428875195 1.5638538931262214 1.290963006433084 0.4690898187767458 0.7410571636148146 0.2147245508952396 0.26196411318595925 1.2647534715989426 0.10820300291615242 0.256916009869763 1.68742924301291e-07 6.772774428875195 -0.8218731876563381 down LLDDPSKQK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLDDPSKQK 9 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925;Q6STE5-2;Q6STE5 J3KMX2 SMARCD2;SMARCD3 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 1 7908400.0 2768300.0 2106400.0 3033700.0 True False 4199713.489839035 1730496.4626216847 2434087.865282056 1.0 0.4120510760575742 0.5795842671580315 22.001859477956618 -10.787310822564205 10.68536828289804 1.0026910726900031 0.4958176716079388 0.923522248407905 0.06839513886271735 0.004388886910089552 8.735936074994424e-05 0.06628617034802683 0.022074436148070652 1.631883598263623e-11 10.787310822564205 -0.5068734010820644 LLDEVFFSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLDEVFFSEK 10 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;H0YKT8;H0YMI6;H0YLC2;H0YLS6 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 8193100.0 0.0 2489900.0 5703200.0 False True 0.0 2118416.625554185 5113087.572957409 0.0 LLDEVFFSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLDEVFFSEK 10 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;H0YKT8;H0YMI6;H0YLC2;H0YLS6 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 9322200.0 3491900.0 1441400.0 4388900.0 False True 3381051.5458694235 2016958.5368016989 3239315.4258222845 1.0 0.5965477040022606 0.9580792785545386 21.689040580350888 -10.30691304949911 8.146642917551244 1.0000005027614962 0.7773134912783997 0.33592956578651556 0.14759464725967608 1.3476086486388846e-06 1.1475302739152785e-07 0.14290822424787014 0.047635967568840296 4.932725526244365e-11 10.30691304949911 -0.22268701148309655 LLDEVFFSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLDEVFFSEK 10 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;H0YKT8;H0YMI6;H0YLC2;H0YLS6 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 4985900.0 3491900.0 0.0 1494000.0 False True 2903669.567399086 0.0 1806388.4925244795 1.0 0.0 0.6221053913316046 21.469445855785164 -10.1807975611991 7.009292624596425 1.0000012478327882 0.3110526956658024 0.6205286343669443 0.2539734624994802 4.95240917730674e-06 5.792435947406403e-07 0.24590919460673497 0.08196958255326009 6.594812292866601e-11 10.1807975611991 -0.6889485521669858 LLDFGSLSNLQVTQPTVGMNFK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LLDFGSLSNLQVTQPTVGMNFK 22 0 H3BNC9;P08708 H3BNC9 RPS17 40S ribosomal protein S17 0 164535200.0 99396700.0 20310600.0 44827900.0 False True 96241406.1655029 28420728.49837976 33086128.181826558 1.0 0.2953066630126502 0.34378267629350223 26.52015438583169 -10.02090183408194 7.450963411388261 1.0000000344806155 0.31954466965307626 0.9962080213342015 0.01979024955041162 1.1340529669331162e-08 1.456224176028356e-09 0.019161827873635236 0.006387275577169386 9.53011554008197e-11 10.02090183408194 -0.6804553648275392 LLDFGSLSNLQVTQPTVGMNFK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LLDFGSLSNLQVTQPTVGMNFK 22 0 H3BNC9;P08708 H3BNC9 RPS17 40S ribosomal protein S17 0 445992000.0 124301000.0 182512000.0 139179000.0 False True 188573704.62033826 149941307.62723526 111670209.64567712 1.0 0.7951337007941649 0.5921833580694958 27.490553274673452 -6.97124117754432 0.22658996091806655 1.0861416485452358 0.295400090503612 0.9999905103043041 0.0005128490335249246 0.07590200388694843 0.007573123622868583 0.005348326597185747 0.020292899658725678 1.0684613638469396e-07 6.97124117754432 -0.7907415580416237 LLDFGSLSNLQVTQPTVGMNFK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LLDFGSLSNLQVTQPTVGMNFK 22 0 H3BNC9;P08708 H3BNC9 RPS17 40S ribosomal protein S17 0 13278870.0 7465700.0 1924770.0 3888400.0 False True 10225971.042956417 1839727.297036774 2970040.004111761 1.0 0.17990734467255962 0.29044087760814713 23.2857345100525 -10.743326918615576 7.034672506418564 1.0119660692359231 0.23517411114035336 0.9845768237456448 0.0451251258598847 0.008289452867065441 0.0003024556535045275 0.04276753681186922 0.014564071745903927 1.805814273239341e-11 10.743326918615576 -0.7767919580955698 LLDFGSLSNLQVTQPTVGMNFK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LLDFGSLSNLQVTQPTVGMNFK 22 0 H3BNC9;P08708 H3BNC9 RPS17 40S ribosomal protein S17 0 162599900.0 99396700.0 24975100.0 38228100.0 False True 82652760.07041925 24840554.179130808 46221418.96323635 1.0 0.300541133266051 0.5592241435598303 26.300559661265968 -10.30438591882322 5.689605278320476 1.0000628340015936 0.429882638413288 0.8662451976948218 0.10560689672449931 8.418181888746978e-05 1.0292066667821866e-05 0.10226463758316279 0.034084479354883394 4.9615124008989626e-11 10.30438591882322 -0.5701801955883056 LLDFGSLSNLQVTQPTVGMNFK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LLDFGSLSNLQVTQPTVGMNFK 22 0 H3BNC9;P08708 H3BNC9 RPS17 40S ribosomal protein S17 0 269591300.0 124301000.0 75010300.0 70280000.0 False True 160910094.8390204 70835910.86564706 57489761.133696325 1.0 0.4402204282864513 0.3572787722933786 27.2616795967659 -13.999999999999998 0.26887807829936133 5.294674029565868 0.32944670060879777 0.9995809216650579 0.0058435102526678195 14.828320970050392 0.16413780578780018 34.786900877318445 0.03464163331431705 1.0000000000000041e-14 13.999999999999998 -4.96522732895707 LLDIACWIHHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLDIACWIHHK 11 0 A0A1B0GW44;A0A1B0GVD5;A0A1B0GWE8;A0A1B0GU92;A0A1B0GU03;P07339;C9JH19;A0A1B0GVP3;A0A1B0GV23;F8WD96;F8W787;A0A1B0GV01 A0A1B0GW44 CTSD Cathepsin D;Cathepsin D light chain;Cathepsin D heavy chain 0 27884700.0 12034000.0 9242500.0 6608200.0 False True 15776690.537421793 7863555.026982826 5924446.854330402 1.0 0.49842867921702155 0.37551898734895056 23.911291268422815 -13.999999999999998 0.1975155039813581 3.7622342284209873 0.29371297542059815 0.9994869974279788 0.006117974340597754 12.482881142542547 0.1409295801629009 13.307248067877085 0.07973753507675264 1.0000000000000041e-14 13.999999999999998 -3.468521253000389 LLDIACWIHHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLDIACWIHHK 11 0 A0A1B0GW44;A0A1B0GVD5;A0A1B0GWE8;A0A1B0GU92;A0A1B0GU03;P07339;C9JH19;A0A1B0GVP3;A0A1B0GV23;F8WD96;F8W787;A0A1B0GV01 A0A1B0GW44 CTSD Cathepsin D;Cathepsin D light chain;Cathepsin D heavy chain 0 9753500.0 7007700.0 1514600.0 1231200.0 False True 6785244.399321043 2119387.6785346577 908711.7847917239 1.0 0.31235244507135684 0.1339246947217779 22.69396935067771 -13.999999999999886 0.1894054111495991 4.678664327868333 0.005150265877599282 0.9994897455246271 0.008434439057955441 12.34108591488484 0.13801223870513865 16.75166328715023 0.12328965757871595 1.0000000000002617e-14 13.999999999999886 -4.673514061990733 LLDIACWIHHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLDIACWIHHK 11 0 A0A1B0GW44;A0A1B0GVD5;A0A1B0GWE8;A0A1B0GU92;A0A1B0GU03;P07339;C9JH19;A0A1B0GVP3;A0A1B0GV23;F8WD96;F8W787;A0A1B0GV01 A0A1B0GW44 CTSD Cathepsin D;Cathepsin D light chain;Cathepsin D heavy chain 0 42973400.0 12034000.0 9454400.0 21485000.0 False True 16483295.00662199 9036673.3464801 16410685.497464567 1.0 0.5482322158797565 0.9955949639238846 23.974501329945706 -10.953308730646341 10.135373562876824 1.0767124675843591 0.771913589901821 0.25738429790029427 0.1826350771062312 0.1009586806066346 0.0004650923489771832 0.0563925651991142 0.05894521767214506 1.1135026869582666e-11 10.953308730646341 -0.3047988776825381 LLDIACWIHHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLDIACWIHHK 11 0 A0A1B0GW44;A0A1B0GVD5;A0A1B0GWE8;A0A1B0GU92;A0A1B0GU03;P07339;C9JH19;A0A1B0GVP3;A0A1B0GV23;F8WD96;F8W787;A0A1B0GV01 A0A1B0GW44 CTSD Cathepsin D;Cathepsin D light chain;Cathepsin D heavy chain 0 26040000.0 4141700.0 14550000.0 7348300.0 False True 5361512.295112439 13740279.709522085 6010984.799925164 1.0 2.5627619509606907 1.121136065547175 22.354208561225157 -6.627011359107595 2.0910571611192643 2.0317911393171784 1.126836996827982 0.10691224508852404 0.6708466744821179 0.5668359809962038 4.71905858859337 0.26273466231793596 0.7434062225561189 2.360416494943745e-07 6.627011359107595 -0.9049541424891963 LLDIEGLYSK(ub)VR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLDIEGLYSKVR 12 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 3826780.0 708580.0 1240500.0 1877700.0 True False 928955.2418984799 1055422.235431128 1683413.6161702415 1.0 1.1361389524797676 1.8121579385567557 19.825249562060176 -6.939959765097851 0.6599441195555779 0.9924067102186425 1.9942393054285446 0.9981585488370518 0.015239922753686033 0.0877850992929772 0.05469461865279125 0.014830351259263914 0.058193958323145514 1.1482599962966901e-07 6.939959765097851 1.001832595209902 LLDIEGLYSK(ub)VR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLDIEGLYSKVR 12 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 21140300.0 3104500.0 7616800.0 10419000.0 True False 4709753.469351332 6257522.529669975 8359680.083190077 1.0 1.32863058977306 1.7749719040689926 22.16722011369455 -6.9668550212210265 0.32464202499047756 0.9421096248356529 2.1759884366648805 0.9999464357700641 0.00232439508332478 0.07733698759330047 0.012669733290331145 0.0066430545621454385 0.03910369282674925 1.0793069627971198e-07 6.9668550212210265 1.2338788118292277 LLDIEGLYSK(ub)VR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLDIEGLYSKVR 12 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 3429080.0 708580.0 1085000.0 1635500.0 True False 970561.1746544942 1037061.1123848053 1249228.5841798135 1.0 1.0685169976575501 1.287119881572144 19.888459623583067 -6.950059850345215 0.5581958243050378 0.9971135115685744 1.368938266150338 0.9992059031755892 0.0034502648363481333 0.0834619042964496 0.03586438585382614 0.0037065984756421027 0.01816474427810306 1.1218638390175645e-07 6.950059850345215 0.37182475458176356 LLDIEGLYSK(ub)VR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLDIEGLYSKVR 12 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 5200700.0 1498500.0 1925400.0 1776800.0 True False 1246069.1448058456 1915027.4880380249 2148320.6650050175 1.0 1.5368549137266472 1.724078213444371 20.248952695551843 -11.300305145028355 0.1942381640633109 1.6595828488680038e-16 1.8760030671077965 0.9994069701078694 0.007473101120189872 3.678337861107011 0.11327137348120186 1.707025148845767 0.12242630087396225 5.0083521193723665e-12 11.300305145028355 1.8760030671077963 LLDIEGLYSK(ub)VR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLDIEGLYSKVR 12 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 15266400.0 3104500.0 3010300.0 9151600.0 True False 4018836.4488438447 2842774.158733628 7486102.703345683 1.0 0.707362490342559 1.8627537593621946 21.938346435787 -6.8395589769035325 1.2843391800495683 0.8443074456141719 1.9004485970922165 0.9237074414197528 0.13546893999540288 0.16931622427950938 0.5427016910331601 0.08271149272423321 0.1905401812762699 1.4469083505553108e-07 6.8395589769035325 1.0561411514780445 LLDLVQQSCNYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLDLVQQSCNYK 12 0 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 0 32332900.0 4616900.0 16757000.0 10959000.0 False True 6052800.610123198 14256920.9182744 9825067.80615098 1.0 2.355425502440963 1.623226740646096 22.529171396247982 -10.218173728480675 4.892822290062763 0.9998520883206999 1.9893261215451694 0.7088130077171008 0.29891889278817657 0.00048237028047018926 7.707909581720424e-05 0.28946942188024216 0.0964756578021396 6.05098771933447e-11 10.218173728480675 0.9894740332244695 LLDLVQQSCNYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLDLVQQSCNYK 12 0 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 0 17282100.0 6804800.0 3804800.0 6672500.0 False True 6588785.348759205 5324076.481769887 4924772.079290756 1.0 0.8080512871424037 0.7474476430193898 22.651581096342394 -13.999999999999998 0.16136051864636072 1.9480895710526438 0.6887566395112045 0.9995328527768177 0.002326730264662864 12.019052424505151 0.12698716329868906 3.566066745921569 0.05358452365816503 1.0000000000000041e-14 13.999999999999998 -1.2593329315414392 LLDLVQQSCNYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLDLVQQSCNYK 12 0 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 0 33821900.0 4616900.0 11856000.0 17349000.0 False True 6323892.697031158 11332162.717450934 13251523.513870722 1.0 1.791959993687271 2.095469380764768 22.592381457770873 -10.418574069416755 0.20980079513048364 1.1531420218454668e-17 2.3284956713979668 0.9993352007118673 0.011907031858739365 2.0887095490216505 0.10483574636842352 1.2811092394521446 0.17420598533158116 3.814397337520484e-11 10.418574069416755 2.3284956713979668 LLDLVQQSCNYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLDLVQQSCNYK 12 0 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 0 12040200.0 6804800.0 2344600.0 2890800.0 False True 5658492.703753634 2331969.1744333375 3495252.9144509793 1.0 0.41211843798727454 0.6177003483864807 22.43198637177667 -10.245338948448918 6.535148085214098 1.0000056754521172 0.5149093931868831 0.8812859367254342 0.08392846347077139 6.940288142805532e-06 8.014120332180039e-07 0.08126433530073919 0.02708779510792287 5.684091384277635e-11 10.245338948448918 -0.48509628226523405 LLDLVQQSCNYK(ub)QLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLDLVQQSCNYKQLR 15 1 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 51121100.0 20199000.0 21481000.0 9441100.0 True False 26481084.607394256 18276118.532282192 8464225.537426041 1.0 0.6901574766759739 0.3196328875087916 24.658458877205007 -7.14203548795052 0.3134152236711361 1.0615010534837714 9.532530461048933e-16 0.9999307463976339 0.0023145286063292123 0.08129896354525554 0.014787500909109857 0.007846739958634082 0.036126970961772656 7.210485569951238e-08 7.14203548795052 -1.0615010534837706 down LLDLVQQSCNYK(ub)QLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLDLVQQSCNYKQLR 15 1 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 80384000.0 42672000.0 26704000.0 11008000.0 True False 41317400.717471845 37367046.459520325 8124674.567078692 1.0 0.9043900586834099 0.19664050559799662 25.300246161154917 -6.931570074634167 0.7337886882885545 1.010160289872066 0.04535725755176792 0.9968379471827704 0.020148209330990156 0.09183071658785161 0.07374579476912638 0.018530487533945948 0.06349525178451701 1.1706576981737016e-07 6.931570074634167 -0.9648030323202982 down LLDLVQQSCNYK(ub)QLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLDLVQQSCNYKQLR 15 1 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 125383000.0 28508000.0 27954000.0 68921000.0 True False 43248720.2139694 22965390.29440109 55298734.14085259 1.0 0.5310073958438944 1.2786212832950146 25.366154106364892 -6.737143239910508 1.6974835704495053 0.7200279558849011 1.2787646830318014 0.5919247503660967 0.1970675851241196 0.3230012569986715 1.8263821270995688 0.09189078164266153 0.22617414397056346 1.8317101842633548e-07 6.737143239910508 0.5587367271469003 LLDLVQQSCNYK(ub)QLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLDLVQQSCNYKQLR 15 1 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 55819000.0 20199000.0 20689000.0 14931000.0 True False 27667116.15745033 19774891.570625998 11404605.31359754 1.0 0.7147435048195626 0.41220795288873846 24.7216689387279 -6.970379926714283 0.2489451197845225 1.0972651476281206 0.02083732016806523 0.9999851954629221 0.0009234205794050601 0.07617960850194601 0.008587934526913433 0.006796187836040029 0.02904539648476095 1.070582335485479e-07 6.970379926714283 -1.0764278274600554 down LLDLVQQSCNYK(ub)QLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLDLVQQSCNYKQLR 15 1 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 78793000.0 42672000.0 25993000.0 10128000.0 True False 35483658.69012678 25852970.54979349 12245717.97341896 1.0 0.7285880741770014 0.34510866200013063 25.080651436589193 -6.9662324504703035 0.3362336162833465 1.0434510957195489 0.017573993532847023 0.9999363382898036 0.0021435840560325445 0.07754523191210022 0.013399054698272243 0.005478011174524284 0.03328514023015174 1.080855282723589e-07 6.9662324504703035 -1.025877102186702 down LLDLVQQSCNYK(ub)QLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLDLVQQSCNYKQLR 15 1 P55769;B1AHD1;A0A3B3IUA2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 1 102036000.0 28508000.0 32921000.0 40607000.0 True False 36904167.976692066 31088917.410115194 33216942.663005196 1.0 0.8424229325465441 0.9000864803125856 25.13728042845734 -10.56688789474289 8.60633523065855 1.000024111453461 0.8712547069458567 0.8692227061668615 0.023541044797567773 1.089306165612519e-05 5.482175554734783e-07 0.022797782176684576 0.007597839537775236 2.7108913090901375e-11 10.56688789474289 -0.1287694045076042 LLDMDGIIVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLDMDGIIVEK 11 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 4261030.0 938930.0 1257600.0 2064500.0 False True 1230946.322611054 1069970.9820864056 1850885.3440823688 1.0 0.8692263524674323 1.5036279893637563 20.231336421486702 -6.852955466576244 1.2206616326000421 0.9299933480120954 1.5304840787953937 0.9445066025627854 0.06442792478953123 0.15423605895366724 0.44074296831641757 0.04126642492663652 0.09569600308072321 1.4029575592570456e-07 6.852955466576244 0.6004907307832983 LLDMDGIIVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLDMDGIIVEK 11 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 4564630.0 938930.0 1896800.0 1728900.0 False True 1286077.794629181 1812993.1041211959 1320569.427813193 1.0 1.4097071823279104 1.026819243227784 20.294546483009594 -10.691051762436325 7.877768450495243 0.9991961817701751 1.218263212777846 0.3022936993798432 0.15631334657685828 0.0022144375513751327 8.684503884612471e-05 0.15187491234372333 0.050449915673510023 2.0367993023959055e-11 10.691051762436325 0.219067031007671 LLDMDGIIVEK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLDMDGIIVEKQR 13 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 12443600.0 3317500.0 5082900.0 4043200.0 True False 4349274.626715702 4324551.132989015 3624848.449113022 1.0 0.994315490317668 0.8334374718136112 22.052343377250516 -6.914391193726525 0.8652909305574884 1.0043163191365694 0.810568466766678 0.9924759709722967 0.006697574004907219 0.10158544836558615 0.12354417237243197 0.005605349410260237 0.015987274691126853 1.217892080074898e-07 6.914391193726525 -0.19374785236989134 LLDMDGIIVEK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLDMDGIIVEKQR 13 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 18233100.0 6498200.0 6036600.0 5698300.0 True False 6291918.197934838 8447045.86045314 4205744.284664294 1.0 1.3425231534678357 0.6684359447083598 22.585068483529632 -6.76857340696244 1.579887113435966 1.1968233839057132 0.664846613924595 0.7250586076305421 0.1443044272200297 0.26875645488697775 1.3236806638447434 0.07200385950206853 0.17162628755480228 1.7038313035644758e-07 6.76857340696244 -0.5319767699811182 LLDMDGIIVEK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLDMDGIIVEKQR 13 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 198453000.0 34780000.0 55733000.0 107940000.0 True False 52763802.75858892 45787010.70608344 86605611.68821743 1.0 0.8677731382549035 1.6413830535389098 25.653045209529832 -6.86288494498569 1.171170432310281 0.9276409443715784 1.6809449639146783 0.9570460671917348 0.07002205810073141 0.1438538585223441 0.37332734177192306 0.04657660079217356 0.10909424698135047 1.371244993703883e-07 6.86288494498569 0.7533040195430999 LLDMDGIIVEK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLDMDGIIVEKQR 13 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 13967700.0 3317500.0 3979400.0 6670800.0 True False 4544069.402066513 3803576.9498839583 5095294.429438522 1.0 0.8370420020773011 1.1213064719304964 22.115553438773407 -6.75123588328957 1.6451860214911542 0.9043196653089169 1.1219272337112705 0.6542603970651296 0.0684809821370125 0.29791798537100705 1.5868615920243359 0.032876102718758585 0.07971365051698123 1.7732261068748259e-07 6.75123588328957 0.2176075684023535 LLDMDGIIVEK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLDMDGIIVEKQR 13 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 21064700.0 6498200.0 5039900.0 9526600.0 True False 5403541.2190706255 5012749.058358173 11518568.013978383 1.0 0.9276785084319823 2.1316702412347848 22.36547375896391 -6.892621693686123 1.0067265636422162 0.9393152505881303 2.2407116208250266 0.9825245768151581 0.07288048830343773 0.1170424802291168 0.20961999062044082 0.0549607288095729 0.1383790739630874 1.280496236323871e-07 6.892621693686123 1.3013963702368962 up LLDSEIK(ub)IMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLDSEIKIMK 10 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 53719000.0 18953000.0 14797000.0 19969000.0 True False 28753086.64990043 12156359.740511328 16022118.397276385 1.0 0.42278451313864157 0.5572312493737736 24.77721350219813 -10.036600018686995 7.427311607564633 1.0000000356526342 0.4900078812565042 0.9504586221037241 0.0548876502264387 3.238970459685503e-08 4.2648993687005285e-09 0.053144741977516965 0.017714912936621214 9.191787621437025e-11 10.036600018686995 -0.50999215439613 LLDSSTVTHLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLDSSTVTHLFK 12 0 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 49160000.0 14312000.0 17301000.0 17547000.0 False True 18763170.597605154 14719758.238769794 15731404.7627093 1.0 0.7845027130248742 0.8384193215573696 24.161400299044868 -10.149349865908894 5.125393404964529 1.0000082316016952 0.811461017290909 0.9422101100941264 0.02201136326174207 2.0705104421392246e-06 3.436713050738468e-07 0.021313341171670674 0.007104136944897575 7.09006365123951e-11 10.149349865908894 -0.18854721431078614 LLDSSTVTHLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLDSSTVTHLFK 12 0 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 50996100.0 16447000.0 7151100.0 27398000.0 False True 15924898.98763263 10006571.52249385 20221641.877618298 1.0 0.6283601252519726 1.269812881910431 23.924780885641077 -6.749616022089594 1.6510934357598888 0.7813686940317169 1.2710621411412557 0.6473457618915428 0.15616366965019354 0.3007368535482632 1.612891113049485 0.07471655766062789 0.18147705178896384 1.7798523564711075e-07 6.749616022089594 0.48969344710953877 LLDSSTVTHLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLDSSTVTHLFK 12 0 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 61519700.0 10255000.0 45950000.0 5314700.0 False True 15557584.740923794 37749863.49101134 4264247.215484241 1.0 2.4264604126957683 0.27409442317015037 23.891114768703098 -6.7280186690450385 1.730586626831921 1.860322938910181 0.2758589401397756 0.5500292514660015 0.5997474430137664 0.33994892002686494 1.993697357232849 0.2747453718652633 0.6832622321854205 1.8706017269597814e-07 6.7280186690450385 -1.5844639987704054 LLDSSTVTHLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLDSSTVTHLFK 12 0 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 47057000.0 14312000.0 18410000.0 14335000.0 False True 19603533.167257242 17596585.32627119 10949368.238592263 1.0 0.8976231568124592 0.5585405521123316 24.22461036056776 -6.949207020343193 0.5674819380942097 1.0042730847515473 0.4354757948463079 0.9991375797758835 0.005540469837163742 0.08380572214204218 0.03729218533614284 0.005886788264782411 0.028235046215497318 1.124069022817272e-07 6.949207020343193 -0.5687972899052394 LLDSSTVTHLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLDSSTVTHLFK 12 0 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 30430900.0 16447000.0 9578300.0 4405600.0 False True 13676409.225640122 9526699.796756314 5326790.59080713 1.0 0.6965790244778537 0.38948751115319236 23.705186161075353 -7.0751691853977485 0.24531542233127773 1.1088748611055086 6.233698255500809e-11 0.9999850817827298 0.0009626583832223576 0.07416198244643554 0.008963952617517824 0.007951708124333377 0.029881112738155566 8.410674284144567e-08 7.0751691853977485 -1.1088748610431716 down LLDSSTVTHLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLDSSTVTHLFK 12 0 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 28513700.0 10255000.0 10718000.0 7540700.0 False True 13275299.6562711 10121533.878120799 6168369.97411588 1.0 0.7624335525518252 0.46465014981428404 23.662241090795547 -6.968069192495783 0.3007559428507063 1.051183841844447 0.16655908831224905 0.9999631588387817 0.001329347376367388 0.07693437006106048 0.011260997308971501 0.004921887036440542 0.026685534364448413 1.0762937231210394e-07 6.968069192495783 -0.8846247535321979 down LLDTK(ub)LMASTQPFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLDTKLMASTQPFK 14 1 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;O95453-3;A0A494C0K5;A0A494C1G3;H3BRK1;O95453-4 O95453 PARN Poly(A)-specific ribonuclease PARN 1 8600200.0 2454500.0 2627400.0 3518300.0 True False 3217873.2694118116 2235402.1615249836 3154260.065916687 1.0 0.6946830948173383 0.9802312899952232 21.617676078359008 -10.508639061916794 8.501714294741534 1.0000108033250876 0.8374571926090166 0.3016913373175798 0.11657456252641303 2.3872474725802e-05 1.3796864821299374e-06 0.1128803316296694 0.03762427827135108 3.0999946054431597e-11 10.508639061916794 -0.162553610716071 LLDTK(ub)LMASTQPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLDTKLMASTQPFK 14 1 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;O95453-3;A0A494C0K5;A0A494C1G3;H3BRK1;O95453-4 O95453 PARN Poly(A)-specific ribonuclease PARN 1 14830400.0 3630500.0 4572300.0 6627600.0 True False 3515251.7647352233 6398043.2342295 4891632.736261876 1.0 1.820081081649472 1.3915454890982255 21.745196589127715 -10.148505476743031 4.33947150444889 0.9999105860370145 1.605813284729601 0.7271237158333643 0.17494892420713404 61182209.2789826 17.87331361351526 74740.6755049476 0.05988966994314673 7.103862115026135e-11 10.148505476743031 0.6059026986925864 LLDTK(ub)LMASTQPFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLDTKLMASTQPFK 14 1 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;O95453-3;A0A494C0K5;A0A494C1G3;H3BRK1;O95453-4 O95453 PARN Poly(A)-specific ribonuclease PARN 1 10600500.0 2454500.0 3995000.0 4151000.0 True False 3361994.9803684247 3818487.6903016535 3170619.292528526 1.0 1.1357803068115242 0.9430767478959987 21.6808861398819 -6.7173472898077256 1.768801836082197 1.0828374084541659 0.9434188440088395 0.5000769247926438 0.05715581120757489 0.36045607494823395 2.2025004165998134 0.025671575962559114 0.06464863952026068 1.9171350630045894e-07 6.7173472898077256 -0.1394185644453264 LLDTK(ub)LMASTQPFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLDTKLMASTQPFK 14 1 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;O95453-3;A0A494C0K5;A0A494C1G3;H3BRK1;O95453-4 O95453 PARN Poly(A)-specific ribonuclease PARN 1 11143200.0 3630500.0 4043300.0 3469400.0 True False 3018921.6084201634 4021517.9403677885 4194835.499306846 1.0 1.3321041292199354 1.3895145497010941 21.52560186456199 -12.420374543226563 0.273467831453457 2.7256353238835322e-14 1.409138322822217 0.9994678388904792 0.003960748149805159 6.500046310462723 0.1581016185109703 3.633870589971557 0.023427412644650487 3.7986165561976436e-13 12.420374543226563 1.4091383228221896 LLDTSTYK(ub)EAFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLDTSTYKEAFR 12 1 Q15126 Q15126 PMVK Phosphomevalonate kinase 1 12548800.0 3049600.0 5927400.0 3571800.0 True False 3998055.132368414 5043055.024824238 3202224.399124923 1.0 1.261377059059407 0.8009455330416998 21.93086693601554 -6.752690996967112 1.6397102351230373 1.153191752977488 0.7998290736036928 0.6605454571990681 0.10985058150583095 0.29537156791204605 1.5632485290794707 0.052902591953501624 0.12808129832024648 1.7672948139243155e-07 6.752690996967112 -0.3533626793737952 LLDTSTYK(ub)EAFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLDTSTYKEAFR 12 1 Q15126 Q15126 PMVK Phosphomevalonate kinase 1 12602400.0 3049600.0 5327200.0 4225600.0 True False 4177119.532341235 5091826.689305381 3227600.3089637533 1.0 1.2189803643113515 0.7726856471245664 21.994076997538432 -6.773274907776039 1.5617806822867515 1.1250753626387968 0.7698504934707494 0.7429691672526204 0.09237702481245984 0.261170636679347 1.2576177875769754 0.04660858706588381 0.11062408891975901 1.685485777592926e-07 6.773274907776039 -0.3552248691680474 LLDVVHPAAK(ub)TLVDIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLDVVHPAAKTLVDIAK 17 1 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 1 10705300.0 3287200.0 3352300.0 4065800.0 True False 3182849.6353223044 4690890.872013553 3000845.008614515 1.0 1.4738022242569873 0.9428170829410359 21.601887571884284 -6.671393292964668 1.932318781962604 1.3020656052110504 0.9449466871774926 0.28522704817656963 0.20119708006722029 0.45796195386547756 3.297937611535316 0.08378199302393965 0.22344797481700815 2.1311141222844666e-07 6.671393292964668 -0.3571189180335578 LLDVVHPAAK(ub)TLVDIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLDVVHPAAKTLVDIAK 17 1 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 1 37345900.0 4367500.0 4565400.0 28413000.0 True False 6625816.807019471 3750668.7003669897 22797158.09613971 1.0 0.5660688802010774 3.4406562632380844 22.659666885140005 -6.868436952057685 1.1422623616227783 0.7567332696470603 3.604129609552254 0.9631018184456169 0.24304594481252603 0.13836610633580285 0.3383835328268283 0.16527597326092963 0.3902905831552978 1.3538266158186352e-07 6.868436952057685 2.8473963399051936 up LLDVVHPAAK(ub)TLVDIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLDVVHPAAKTLVDIAK 17 1 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 1 8856400.0 3287200.0 3013200.0 2556000.0 True False 2733452.447651497 2996967.293526632 3090447.782391279 1.0 1.0964036693235835 1.1306023578520643 21.38229284731856 -13.999999914787754 0.1443739339589498 0.537408642640394 1.1707750129948498 0.9995860758558001 0.0011250171713150926 11.941033230083065 0.11934701856739267 1.5527923473013705 0.036029791911535325 1.000000196208467e-14 13.999999914787754 0.6333663703544558 LLDVVHPAAK(ub)TLVDIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLDVVHPAAKTLVDIAK 17 1 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 1 37076700.0 4367500.0 7311200.0 25398000.0 True False 5653814.84629586 6904325.292938679 20775824.60548689 1.0 1.2211799432134043 3.6746559925106728 22.430793207232455 -6.924560028926981 0.7901713936066895 0.9542335370106846 4.115003737044851 0.9953567336977788 0.08259299635816082 0.09556230914957031 0.09225124707023154 0.07293889450072609 0.22899478668296946 1.189706874473236e-07 6.924560028926981 3.160770200034166 up LLEAAAQSTK(ub)GYYSPYSVSGSGSTAGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLEAAAQSTKGYYSPYSVSGSGSTAGSR 28 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 1 8532200.0 1482000.0 2999100.0 4051100.0 True False 1434954.721205788 4196656.270099891 2989995.3796050623 1.0 2.9245914230474495 2.08368622049104 20.452573783909827 -10.048521486916844 4.6945020856441975 0.9999502448316995 2.504138821767686 0.8101024196399089 0.34329811153546436 119813315.03219275 74047684.36689001 72289.73180758307 0.1256342453209601 8.942902854197558e-11 10.048521486916844 1.5041885769359866 LLEAAAQSTK(ub)GYYSPYSVSGSGSTAGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLEAAAQSTKGYYSPYSVSGSGSTAGSR 28 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 1 9224700.0 1482000.0 3669400.0 4073300.0 True False 1232348.6637319082 3649632.213881131 4925008.197188733 1.0 2.9615256796148817 3.9964405708644044 20.232979059344103 -8.832778727587979 0.2585155267142501 3.294006572526697e-17 4.688439634029603 0.9991168199799287 0.036929071239015315 0.35142906072935115 0.08216700471723763 0.7320516222149153 0.40891382956874817 1.4696748841540444e-09 8.832778727587979 4.688439634029603 LLEAQACTGGIIHPTTGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLEAQACTGGIIHPTTGQK 19 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 9716800.0 2759900.0 2387300.0 4569600.0 False True 2672288.48519288 3340561.3396050325 3372684.674938484 1.0 1.2500751165583524 1.2620960250461324 21.3496443307631 -12.261424207537797 0.46122521171004266 7.782073356884589e-10 1.2619585787553724 0.9998675850127225 0.001390279883179525 7.594945626110686 0.23084810364378328 7.406804957749841 0.002646729294952615 5.477416837294839e-13 12.261424207537797 1.2619585779771652 LLEAQACTGGIIHPTTGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLEAQACTGGIIHPTTGQK 19 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 56632400.0 7519400.0 40926000.0 8187000.0 False True 11407479.541774966 33622435.543702506 6568835.86151042 1.0 2.9474026598579344 0.5758358660609381 23.443476730661658 -6.688518744180227 1.8713438031987606 2.2226428267863794 0.5841360167694754 0.36342777125281067 0.82387584463117 0.41998936907267725 2.850313543005274 0.3523228589548277 0.9193034734813283 2.0487136254258905e-07 6.688518744180227 -1.638506810016904 LLEAQACTGGIIHPTTGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLEAQACTGGIIHPTTGQK 19 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 31051600.0 10255000.0 11617000.0 9179600.0 False True 14046550.63095465 11103722.52771822 7011567.539796409 1.0 0.7904946074980669 0.4991665017278253 23.743712559883065 -6.96648575380384 0.33156549928308027 1.0348513672131183 0.24525036882222545 0.9999405755009142 0.0015831461868843035 0.07746033881248732 0.013101589952420719 0.004227553809796377 0.025378474867874794 1.0802250550084324e-07 6.96648575380384 -0.7896009983908929 down LLEAQACTGGIIHPTTGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLEAQACTGGIIHPTTGQK 19 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 26613900.0 7519400.0 11934000.0 7160500.0 False True 9734011.529533383 11269862.4091709 5857362.472934432 1.0 1.1577819047139695 0.601741887726654 23.214603052754107 -6.830914607970874 1.3240272105410065 1.0842529237790652 0.5865199022418475 0.9076516891328156 0.07110136854692667 0.17968748588733707 0.6157693359932093 0.04216205879135663 0.09701424779334672 1.4759967187833822e-07 6.830914607970874 -0.49773302153721777 LLEAQIATGGIIDPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLEAQIATGGIIDPK 15 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 17713100.0 6567800.0 6487800.0 4657500.0 False True 9963832.77049627 5330001.40058724 3736943.0835452317 1.0 0.5349348512120571 0.3750507630568257 23.24826937741433 -13.999999999999998 0.1489846453108596 3.245342073883632 0.19707639977313393 0.9995696642538965 0.0054989732015413755 11.954034340676063 0.12150814793067942 7.772678134432928 0.16026081119478247 1.0000000000000041e-14 13.999999999999998 -3.0482656741104983 LLEAQIATGGIIDPVHSHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLEAQIATGGIIDPVHSHR 19 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1;A0A075B730;P58107 Q15149 PLEC;EPPK1 Plectin;Epiplakin 0 15191000.0 2682600.0 8337200.0 4171200.0 False True 4069700.324329808 6849361.521159086 3346760.491698095 1.0 1.6830137295888068 0.8223604258255145 21.95649113371232 -6.695249642754727 1.8478795172161258 1.4260882703246427 0.8251437094429892 0.395020960126813 0.28856745458010963 0.4054966869632594 2.6884764132994787 0.12474489451459503 0.3226972907220168 2.017206492282194e-07 6.695249642754727 -0.6009445608816535 LLEDGEDFNLGDALDSSNSMQTIQK(ub)TTTR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LLEDGEDFNLGDALDSSNSMQTIQKTTTR 29 1 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 99321700.0 10503100.0 12959600.0 75859000.0 True False 10169684.839606266 18134435.863421183 55989252.178781055 1.0 1.7831856295876405 5.505505142177912 23.27777163471645 -6.940942405661083 0.6507365447685568 0.9588024209843286 6.537752819840308 0.9982847576764863 0.08140202448829155 0.08733930444391691 0.05267132500989632 0.07981645891320911 0.3190657096186433 1.1456648647100392e-07 6.940942405661083 5.578950398855979 LLEDGEDFNLGDALDSSNSMQTIQK(ub)TTTR ddPTM_RPMI8226_Bortezomib_8h_R1 2 LLEDGEDFNLGDALDSSNSMQTIQKTTTR 29 1 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 278561900.0 14731700.0 73159200.0 190671000.0 True False 22349065.931532644 60103369.16456145 152984793.27593204 1.0 2.6893011702901046 6.845243275249523 24.413711200134404 -6.955805359191593 0.4909981439808598 0.9098676500203667 8.801204849603696 0.9995815962284847 0.050239615441227896 0.08123504903971203 0.026938131165382392 0.05996585368904599 0.3427700134554916 1.1071198584880715e-07 6.955805359191593 7.8913371995833295 LLEDGEDFNLGDALDSSNSMQTIQK(ub)TTTR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LLEDGEDFNLGDALDSSNSMQTIQKTTTR 29 1 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 75943700.0 10503100.0 18464200.0 46976400.0 True False 8733793.016223066 18364729.689743258 56798948.04566735 1.0 2.102720966209146 6.503354034170837 23.058176910150728 -6.944928065930959 0.6120008242125686 0.9514560467090903 7.8845786298747615 0.9987407303049627 0.08436502902493283 0.08558858690718199 0.04489984543737639 0.08559345464937465 0.37133574884263604 1.13519882798156e-07 6.944928065930959 6.933122583165671 LLEDGEDFNLGDALDSSNSMQTIQK(ub)TTTR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LLEDGEDFNLGDALDSSNSMQTIQKTTTR 29 1 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 290326200.0 14731700.0 70164500.0 205430000.0 True False 19070476.055220786 66259783.895447545 168043847.8898011 1.0 3.474469316003681 8.811728003182017 24.184837522226854 -6.958541071167629 0.4555316733900487 0.8372896167966392 11.662457382733486 0.9997121966097332 0.05530052770844352 0.08022649103391566 0.02308870171280039 0.07195197173219284 0.44114342618540986 1.1001677976631577e-07 6.958541071167629 10.825167765936847 LLEDK(ub)NGEVQNLAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLEDKNGEVQNLAVK 15 1 Q86VP6;Q86VP6-2;F5H6I6;A0A3B3ISC4;F8WBB8;O75155-2;O75155 Q86VP6 CAND1;CAND2 Cullin-associated NEDD8-dissociated protein 1;Cullin-associated NEDD8-dissociated protein 2 1 6530900.0 1545800.0 2475800.0 2509300.0 True False 2026558.769548494 2106420.290592814 2249661.7069052523 1.0 1.0394074537804363 1.1100895472212062 20.95060058300489 -6.962117541963625 0.40448576301401457 0.996301629565284 1.1557950522630416 0.9998408347693204 0.000574562086968946 0.07895320615340018 0.018398899624542563 0.0009093265584717006 0.00591240275831212 1.0911449776856052e-07 6.962117541963625 0.15949342269775757 LLEDK(ub)NGEVQNLAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLEDKNGEVQNLAVK 15 1 Q86VP6;Q86VP6-2;F5H6I6;A0A3B3ISC4;F8WBB8;O75155-2;O75155 Q86VP6 CAND1;CAND2 Cullin-associated NEDD8-dissociated protein 1;Cullin-associated NEDD8-dissociated protein 2 1 5923700.0 1642400.0 1978400.0 2302900.0 True False 1590262.9110043063 2768385.4372197054 1699701.4044808783 1.0 1.7408350644808623 1.0688178619518063 20.60083386882523 -10.389542239294595 6.0564302498676135 0.9999187030886539 1.4048264632163345 0.32607996305427456 0.2743498740947953 0.0003012199837962118 3.036144583934396e-05 0.26569112404349327 0.08854604111693681 4.0780989642718576e-11 10.389542239294595 0.4049077601276806 LLEDK(ub)NGEVQNLAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLEDKNGEVQNLAVK 15 1 Q86VP6;Q86VP6-2;F5H6I6;A0A3B3ISC4;F8WBB8;O75155-2;O75155 Q86VP6 CAND1;CAND2 Cullin-associated NEDD8-dissociated protein 1;Cullin-associated NEDD8-dissociated protein 2 1 4293900.0 1545800.0 2748100.0 0.0 True False 2117324.0336742764 2626679.855248559 0.0 1.0 1.24056583379464 0.0 21.01381064452778 -6.901356463744656 1.2957639220819535 1.1253622037169984 8.03832427967794e-21 0.9477787155561591 0.122751860951447 0.13362768962340538 0.45023393411968105 0.07740728552549377 0.15406317776285333 1.254999452215242e-07 6.901356463744656 -1.1253622037169984 down LLEDK(ub)NGEVQNLAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLEDKNGEVQNLAVK 15 1 Q86VP6;Q86VP6-2;F5H6I6;A0A3B3ISC4;F8WBB8;O75155-2;O75155 Q86VP6 CAND1;CAND2 Cullin-associated NEDD8-dissociated protein 1;Cullin-associated NEDD8-dissociated protein 2 1 7867400.0 1642400.0 4549100.0 1675900.0 True False 1365728.3706567357 4524593.095374351 2026322.941513906 1.0 3.312952408829742 1.4836939651034058 20.381239144259506 -6.58745990022342 2.2387440055511765 2.5679565345409405 1.488855921108518 0.0 1.0029349079999912 0.6770791633768615 6.393888046729081 0.3745549635732855 1.1184863210464182 2.585473553453124e-07 6.58745990022342 -1.0791006134324226 LLEEVQLLK(ub)PR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLEEVQLLKPR 11 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 46713600.0 9164600.0 14736000.0 22813000.0 True False 12014879.35011264 12537446.2404781 20452529.597748194 1.0 1.0434933115129919 1.702266747901755 23.51831882563245 -6.920306781094125 0.8224488499087987 0.9856248714368551 1.8092530094364654 0.9942657297139581 0.024329769049939443 0.09799151281739026 0.10468146903964784 0.020996726314663396 0.06308075845532998 1.2014154674415183e-07 6.920306781094125 0.8236281379996103 LLEEVQLLK(ub)PR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLEEVQLLKPR 11 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 71385000.0 13048000.0 21774000.0 36563000.0 True False 12633798.382114094 30468471.749909967 26986053.4335118 1.0 2.41166360490957 2.1360205867869846 23.590785118315875 -10.166910978498322 4.845780425917081 0.9998830098970377 2.2738420958530425 0.9660738641005249 0.11253079094327761 0.00014224119913412684 2.4454263528391976e-05 0.1089672841929122 0.03631915660256607 6.809089168156089e-11 10.166910978498322 1.2739590859560048 LLEEVQLLK(ub)PR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLEEVQLLKPR 11 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 73690000.0 15901000.0 23762000.0 34027000.0 True False 24122979.518813223 19521485.4466466 27301548.535436112 1.0 0.8092485188830852 1.1317651915321638 24.52390477507893 -6.746467598515398 1.6631131350405164 0.8873620245400171 1.132230453206838 0.6335801602873293 0.08014452095209652 0.30623253112654225 1.6654073938813372 0.0380876911257675 0.09280510675366342 1.7928023032920387e-07 6.746467598515398 0.2448684286668208 LLEEVQLLK(ub)PR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLEEVQLLKPR 11 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 49051600.0 9164600.0 10387000.0 29500000.0 True False 12553000.284002628 9928067.994784294 22532707.571571093 1.0 0.7908920393665957 1.7950057406026245 23.58152888715534 -6.852364545950824 1.223624352719199 0.8881449129069363 1.8370153048339428 0.9436758098535979 0.10265919591483713 0.154875616131612 0.44504342157544136 0.06560761285252112 0.1520674489995651 1.4048677857532375e-07 6.852364545950824 0.9488703919270065 LLEEVQLLK(ub)PR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLEEVQLLKPR 11 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 60501000.0 13048000.0 20095000.0 27358000.0 True False 10849990.124408845 19986744.246454794 33078431.310900044 1.0 1.8420979205770254 3.0487061215368896 23.37119039375015 -6.966007052020505 0.3403258113464412 0.8696189985096816 4.061303781172164 0.9999324247857735 0.006911573946330653 0.07762086135902253 0.013664089269612158 0.01701602322488567 0.10441222600379865 1.0814163912487095e-07 6.966007052020505 3.1916847826624823 LLEEVQLLK(ub)PR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLEEVQLLKPR 11 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 59374000.0 15901000.0 16541000.0 26932000.0 True False 20584157.95556968 15620478.809292415 22030652.34565605 1.0 0.7588592568619408 1.0702722158083213 24.29503109717138 -6.69997119901406 1.8307092171361763 0.8502530436440997 1.0693510358506926 0.41741969714714167 0.1017899573539653 0.39565872106796024 2.5779488468571548 0.044355034932915545 0.11408463978370846 1.9953946386105082e-07 6.69997119901406 0.21909799220659287 LLEFHIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLEFHIQK 8 0 Q63HN1;Q6ZU69 Q63HN1 FAM205BP;FAM205A Putative protein FAM205B;Protein FAM205A 0 13399900.0 2946400.0 5396800.0 5056700.0 False True 3862758.93297819 4591618.476561635 4533481.191291503 1.0 1.188688850697057 1.1736381353200795 21.881200214005336 -10.079080690751713 4.473310954088531 0.999986243388943 1.1811634930194808 0.9948501776429428 0.006144428859947717 8.430648149565456e-07 1.7355210010956489e-07 0.005949769238347616 0.001983105882015844 8.335263032768144e-11 10.079080690751713 0.18117724963053772 LLEFHIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLEFHIQK 8 0 Q63HN1;Q6ZU69 Q63HN1 FAM205BP;FAM205A Putative protein FAM205B;Protein FAM205A 0 8783100.0 2946400.0 1756400.0 4080300.0 False True 4035763.7034660964 1678796.44036191 3116617.1764163217 1.0 0.41597986495593975 0.7722496670802678 21.944410275528227 -10.34286130506322 6.424789835518262 1.000024345866952 0.5941147660181337 0.6337750527285797 0.1454465376611558 5.0724112167704525e-05 5.188252705776014e-06 0.14083643391534573 0.04694266817709883 4.540866091858606e-11 10.34286130506322 -0.40590957984881826 LLEFQLALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLEFQLALK 9 0 P31948;P31948-2;P31948-3;H0YGI8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 59810170.0 29112170.0 12907000.0 17791000.0 False True 28188020.098546207 18060832.40911582 13131003.381440502 1.0 0.6407272432038356 0.46583631399204695 24.74857881206234 -13.999999999999988 0.09467985951934285 2.8055828070010245 0.06059241574393677 0.9998200282780555 0.002983028726618188 12.123039520821418 0.09051560887939764 4.340133649188846 0.3626962672366687 1.0000000000000286e-14 13.999999999999988 -2.7449903912570877 LLEFQLALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLEFQLALK 9 0 P31948;P31948-2;P31948-3;H0YGI8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 1445053000.0 460561000.0 558804000.0 425688000.0 False True 698704708.519221 459081060.24441975 341550580.2143219 1.0 0.6570458945630402 0.4888339466584918 29.380107621616496 -13.999999999999995 0.09336966016463172 2.7320500880499323 0.09066704195929143 0.9998263786471152 0.0028027550869136656 12.134131540613106 0.08959017610490938 4.125940596516773 0.356721655181086 1.0000000000000123e-14 13.999999999999995 -2.641383046090641 LLEFQLALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLEFQLALK 9 0 P31948;P31948-2;P31948-3;H0YGI8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 15724400.0 3595900.0 3384200.0 8744300.0 False True 4925401.405543618 3234674.8539471477 6679076.434511499 1.0 0.6567332462094296 1.3560471288683378 22.23180987403305 -6.773250489715519 1.5621252126419207 0.8039251347596275 1.3604607219715796 0.7427697195213194 0.14480439525970715 0.2612211973189241 1.2584537781468554 0.07304823250729907 0.17336375046570462 1.6855805461254752e-07 6.773250489715519 0.5565355872119522 LLEFQLALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLEFQLALK 9 0 P31948;P31948-2;P31948-3;H0YGI8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 64630170.0 29112170.0 17603000.0 17915000.0 False True 24208059.2428044 17508169.14507807 21660943.67039894 1.0 0.7232372066456421 0.8947823306751629 24.528984087496617 -10.404901051802012 5.528861300020951 1.000097901017773 0.8090097690482307 0.6230311448922667 0.07003300362246717 8.455783950932855e-05 9.101353486207671e-06 0.0678438177926571 0.022603054726224363 3.936397508001476e-11 10.404901051802012 -0.19108813196954233 LLEFQLALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLEFQLALK 9 0 P31948;P31948-2;P31948-3;H0YGI8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 1253783000.0 460561000.0 428181000.0 365041000.0 False True 596205293.5145665 404352350.948651 298607283.6369614 1.0 0.678209930953543 0.5008464146245722 29.151233943708945 -11.933067152752525 0.08945716695481123 2.211476436045303 5.320745137595197e-24 0.9999009819851479 0.0020558468487855037 5.48555559495876 0.06539980394349594 1.642393624306759 0.36715999484553563 1.1666292131570282e-12 11.933067152752525 -2.211476436045303 LLEGDGGPNTGGMGAYCPAPQVSNDLLLK(ub)IK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLEGDGGPNTGGMGAYCPAPQVSNDLLLKIK 31 1 P22102;P22102-2;F8WD69 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 94192000.0 11227000.0 13178000.0 69787000.0 True False 17032179.803642258 10826282.93981606 55993568.861271285 1.0 0.6356369569032442 3.287516307765686 24.021759749296027 -6.872177986550423 1.1224610660222691 0.7909318127797567 3.449423399885906 0.9668113929727721 0.21381998364623686 0.13478618567782 0.3160584402101737 0.1476283031885094 0.35091272294969467 1.342214769627886e-07 6.872177986550423 2.658491587106149 up LLEGDGGPNTGGMGAYCPAPQVSNDLLLK(ub)IK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLEGDGGPNTGGMGAYCPAPQVSNDLLLKIK 31 1 P22102;P22102-2;F8WD69 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 92010000.0 11227000.0 10536000.0 70247000.0 True False 14533572.817255542 9949662.338111652 57462766.79508768 1.0 0.6845985129202734 3.953794948951768 23.792886071388477 -6.883221203554527 1.0616338706973718 0.7947526919916971 4.200317813763581 0.9761937228983619 0.22718292823769934 0.12481662704707017 0.255348489170672 0.16433248373987516 0.4008715557166884 1.308515274059259e-07 6.883221203554527 3.405565121771884 up LLEGEEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLEGEEER 8 0 Q03252;P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q3BDU5;Q5TCI8;P20700;E9PBF6 Q03252;P02545;P02545-2;P20700 LMNB2;LMNA;LMNB1 Lamin-B2;Prelamin-A/C;Lamin-A/C;Lamin-B1 0 9607900.0 3465900.0 1231800.0 4910200.0 False True 3355876.901637742 1723664.1637521407 3624071.317157507 1.0 0.5136255632353364 1.079917834706297 21.678258365955926 -6.679364332437947 1.9039310626216643 0.6920936361104806 1.077762887799407 0.3213031737308467 0.20616512585472843 0.43994198024947473 3.0827193107923025 0.08690135200421073 0.22940135622235625 2.0923564280990062e-07 6.679364332437947 0.3856692516889264 LLEHK(ub)EIDGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLEHKEIDGR 10 1 A0A087X2I1;P62333;H0YJC0;H0YJS8;H0YJE9;H0YJT1;H0YJD2;H0YJY8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 57208400.0 25795000.0 23061000.0 8352400.0 True False 33817494.79913533 19620388.69107392 7488173.769878224 1.0 0.5801845703714159 0.22142899154285334 25.011266453032995 -7.800268073484014 0.31486426827641545 1.0971408388318056 3.121162342301602e-10 0.999262579393859 0.008640221525293004 0.1176587591485076 0.050576315465365 0.04027562928119449 0.08197723798198316 1.5839151999763363e-08 7.800268073484014 -1.0971408385196892 down LLEHK(ub)EIDGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLEHKEIDGR 10 1 A0A087X2I1;P62333;H0YJC0;H0YJS8;H0YJE9;H0YJT1;H0YJD2;H0YJY8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 53474330.0 24697200.0 20185830.0 8591300.0 True False 23913200.904563814 28246137.18671283 6340980.796524631 1.0 1.1811943244002137 0.26516654218860597 24.511303919315868 -6.855317592540405 1.2090830051117278 1.097335120375817 0.22459880224129591 0.9476953448649685 0.09058446610926085 0.15170946191681162 0.4241088460572975 0.0585324714688702 0.13599770379478582 1.3953475927071828e-07 6.855317592540405 -0.8727363181345211 down LLEHK(ub)EIDGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLEHKEIDGR 10 1 A0A087X2I1;P62333;H0YJC0;H0YJS8;H0YJE9;H0YJT1;H0YJD2;H0YJY8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 109305600.0 53514600.0 39018000.0 16773000.0 True False 81185560.64131065 32054933.050974596 13457809.198132932 1.0 0.3948353968090194 0.1657660437622824 26.27471982211978 -10.542647847405496 0.21124764995177528 1.79988356917424 1.157247209134775e-14 0.9993211097573093 0.009169515514621805 2.2854140391532916 0.10833260605711596 1.0828014330907318 0.12905822065885422 2.8665013628678407e-11 10.542647847405496 -1.7998835691742285 LLEHK(ub)EIDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLEHKEIDGR 10 1 A0A087X2I1;P62333;H0YJC0;H0YJS8;H0YJE9;H0YJT1;H0YJD2;H0YJY8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 53801090.0 25795000.0 17560090.0 10446000.0 True False 35332108.58366408 16784227.16034775 7978869.942123108 1.0 0.47504176323368347 0.2258249015404692 25.074476514555887 -9.691937450814484 0.20158825286192228 1.54419241495548 3.2770827917819574e-21 0.9994484799547653 0.007577705177988986 1.1326748849548334 0.08470210687451146 0.501294632143668 0.14240845962782084 2.0326497418730189e-10 9.691937450814484 -1.54419241495548 LLEHK(ub)EIDGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLEHKEIDGR 10 1 A0A087X2I1;P62333;H0YJC0;H0YJS8;H0YJE9;H0YJT1;H0YJD2;H0YJY8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 68872550.0 24697200.0 38451450.0 5723900.0 True False 20536816.071470764 38244304.406834744 6920741.025676624 1.0 1.8622314322599784 0.33699191742242585 24.291709194750144 -6.753297310026278 1.637385619141224 1.5049601476888868 0.33312065200717883 0.6632043307456552 0.3623907384458123 0.29429355307398486 1.553288195889996 0.17475601804440635 0.42284484859941346 1.7648292373624534e-07 6.753297310026278 -1.171839495681708 LLEHK(ub)EIDGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLEHKEIDGR 10 1 A0A087X2I1;P62333;H0YJC0;H0YJS8;H0YJE9;H0YJT1;H0YJD2;H0YJY8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 114305900.0 53514600.0 51100000.0 9691300.0 True False 69275704.63047154 48256240.07948991 7927582.841135324 1.0 0.6965824503250735 0.11443525379384312 26.04584614421223 -7.34136164856434 0.5680824853314402 1.0038861384263928 1.1470668650637688e-25 0.9969572857219351 0.02026889463191524 0.103902645332652 0.06685834739921442 0.019988092549257416 0.06175741837004527 4.556573199557e-08 7.34136164856434 -1.0038861384263928 down LLEIDPYLK(ub)PYAVDFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLEIDPYLKPYAVDFQR 17 1 Q04446 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 1 4896220.0 891320.0 2105900.0 1899000.0 True False 863025.5344839011 2946796.852123419 1401594.93122115 1.0 3.414495555899903 1.6240480440237721 19.719043719737122 -6.569572264853073 2.3075686299348224 2.6543568239381803 1.627635610225124 0.0 1.0516806486548669 0.7313124179535311 7.309237564793421 0.38518589634249983 1.1794751275824877 2.694186993183251e-07 6.569572264853073 -1.0267212137130564 LLEIDPYLK(ub)PYAVDFQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLEIDPYLKPYAVDFQR 17 1 Q04446 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 1 4222520.0 891320.0 1222900.0 2108300.0 True False 741172.0721710683 1216311.9949733543 2549135.7823221968 1.0 1.641065604928271 3.4393305927666367 19.4994489951714 -6.952950055868349 0.5254588972655793 0.97068174434259 4.190717161502873 0.9994129263289001 0.025017781105841387 0.0823223184714305 0.03122375415340563 0.028101852416273575 0.14862436370480178 1.1144226855148149e-07 6.952950055868349 3.2200354171602825 LLEIQTEK(ub)NK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLEIQTEKNK 10 1 B3KVZ3;Q9H3R5;H0Y9E6 B3KVZ3 CENPH Centromere protein H 1 4659200.0 1336400.0 1549600.0 1773200.0 True False 1752033.3417160118 1318405.720293492 1589726.273735462 1.0 0.7525003599544473 0.9073607424493533 20.74059879944057 -10.383653057482105 5.572952916848787 1.0000624814622527 0.8299305513642155 0.6165778310303984 0.06322148641412892 4.909817515236048e-05 5.430008258589794e-06 0.06123639135757279 0.020404647000366115 4.1337760288187757e-11 10.383653057482105 -0.1701319300980373 LLEIQTEK(ub)NK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLEIQTEKNK 10 1 B3KVZ3;Q9H3R5;H0Y9E6 B3KVZ3 CENPH Centromere protein H 1 5583400.0 1609900.0 1438600.0 2534900.0 True False 1558794.6057147067 2013040.4821998912 1870933.6446300687 1.0 1.291408422135842 1.2002438536616864 20.571999413435353 -10.090495323173307 4.38587786062591 0.9999760526241003 1.245826137865246 0.9064973617198702 0.037217779305706404 25882410.987170238 0.08391799426368195 6590.629573134124 0.012740635780005578 8.11903992113346e-11 10.090495323173307 0.2458500852411457 LLEIQTEK(ub)NK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLEIQTEKNK 10 1 B3KVZ3;Q9H3R5;H0Y9E6 B3KVZ3 CENPH Centromere protein H 1 4506600.0 1336400.0 1239600.0 1930600.0 True False 1830503.194852055 1184830.3731909709 1474632.041955088 1.0 0.6472703115313225 0.80558834647337 20.80380886096346 -10.050355555065916 4.575962323463 1.0000103742723496 0.7264293289970855 0.7992462800071927 0.0646330671710234 89538120.58591296 0.3144459371285069 11647.539360953107 0.02212561802292567 8.905215733435174e-11 10.050355555065916 -0.27358104527526417 LLEIQTEK(ub)NK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLEIQTEKNK 10 1 B3KVZ3;Q9H3R5;H0Y9E6 B3KVZ3 CENPH Centromere protein H 1 6856000.0 1609900.0 3574500.0 1671600.0 True False 1338703.180662616 3555243.4590173005 2021123.8313948575 1.0 2.655736917916014 1.5097624780382346 20.35240468886963 -10.507617452990324 5.377521566528243 0.9975638232176209 2.0827496979747573 0.5434350152682738 0.46784210599540604 0.01368331547192817 0.0012528867133026593 0.4535893231621132 0.1509953904312316 3.107295435012227e-11 10.507617452990324 1.0851858747571363 LLEIQTEK(ub)NK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLEIQTEKNK 10 1 B3KVZ3;Q9H3R5;H0Y9E6 B3KVZ3 CENPH Centromere protein H 1 21334500.0 2898500.0 5357000.0 13079000.0 True False 3752165.3879767684 5058878.240818541 10698756.201872706 1.0 1.3482556651231128 2.851355176441638 21.839291989702843 -6.943131131630728 0.6297593977493742 0.9836036902605069 3.2969828071122147 0.9985459421465286 0.03063281110362868 0.08636676175554135 0.04831940549247248 0.030580549550698867 0.12769194258469685 1.1399055505307846e-07 6.943131131630728 2.3133791168517077 up LLELFPVNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLELFPVNR 9 0 E7ETZ4;Q9Y6E2;Q75MG1;B5MCH7;E9PFD4;B5MCE7 E7ETZ4 BZW2 Basic leucine zipper and W2 domain-containing protein 2 0 5809500.0 1300500.0 2090000.0 2419000.0 False True 1704968.094059916 1778180.1467561922 2168705.0846864884 1.0 1.0429404239008027 1.2719915945889106 20.70131331093595 -6.938372751913541 0.6745304266127147 0.9973422763661388 1.3309110087577005 0.997942930390189 0.005414964090311081 0.08851682517184661 0.05804907124085824 0.005208221012304696 0.01985945908928612 1.1524636816985259e-07 6.938372751913541 0.3335687323915617 LLELFPVNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLELFPVNR 9 0 E7ETZ4;Q9Y6E2;Q75MG1;B5MCH7;E9PFD4;B5MCE7 E7ETZ4 BZW2 Basic leucine zipper and W2 domain-containing protein 2 0 3480230.0 1575500.0 845730.0 1059000.0 False True 1525486.6148850985 1183434.3994236856 781616.1306809899 1.0 0.7757750136095578 0.5123716740968338 20.54083809062153 -6.969001051063041 0.2810304802128513 1.0573137712304153 0.22279521743308603 0.9999735043100453 0.001025795488042823 0.07662825787405918 0.010185663588225771 0.004836670889622218 0.024145817870836934 1.0739868131159284e-07 6.969001051063041 -0.8345185537973292 LLELFPVNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLELFPVNR 9 0 E7ETZ4;Q9Y6E2;Q75MG1;B5MCH7;E9PFD4;B5MCE7 E7ETZ4 BZW2 Basic leucine zipper and W2 domain-containing protein 2 0 6898000.0 1300500.0 2480000.0 3117500.0 False True 1781329.9946910327 2370425.3997366955 2381210.7069278928 1.0 1.3307053756470542 1.336760013037847 20.764523372458843 -11.765533658240797 0.6188284166364212 1.0396651173351374e-06 1.3359477543215077 0.9999686807789977 0.0008805261034486505 6.235374534372934 0.3098445198658608 8.34276465404873 0.0010291876895847782 1.7157987289132876e-12 11.765533658240797 1.3359467146563904 LLELGQK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLELGQKQR 9 1 E9PP05;Q86TE4-3;Q86TE4-2;Q86TE4 E9PP05 LUZP2 Leucine zipper protein 2 1 33564100.0 7577100.0 13585000.0 12402000.0 True False 9933651.476740777 11558170.953915238 11118760.00838439 1.0 1.1635369915059135 1.1193024070170463 23.243892699872404 -10.113690013076088 4.416165571867503 0.9999831469133493 1.141419699210959 0.931638318337427 0.018058693525042135 3.0647962588024117e-06 6.150994053790783e-07 0.017487385305522223 0.005828418269119365 7.696796194686318e-11 10.113690013076088 0.14143655229760976 LLELGQK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLELGQKQR 9 1 E9PP05;Q86TE4-3;Q86TE4-2;Q86TE4 E9PP05 LUZP2 Leucine zipper protein 2 1 88871000.0 26223000.0 23770000.0 38878000.0 True False 25390565.21874451 33261484.958912488 28694685.48500049 1.0 1.3099938765584194 1.13013181226138 24.597789175353057 -9.963028106716198 4.990194586675214 0.9999985281786369 1.2200628444140464 0.6662177854673701 0.07342838028294194 50419332.19588077 4.868071089162747 852.6604881718946 0.025136487649090846 1.0888596221209259e-10 9.963028106716198 0.22006431623540956 LLELGQK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLELGQKQR 9 1 E9PP05;Q86TE4-3;Q86TE4-2;Q86TE4 E9PP05 LUZP2 Leucine zipper protein 2 1 38406000.0 10731000.0 9635000.0 18040000.0 True False 16279711.541185122 7915558.971401409 14474386.092787098 1.0 0.48622231121087645 0.8891058085500574 23.956571801052267 -9.878748922162792 6.564184597102046 1.000000013630849 0.6876640598804524 0.4448616288367627 0.1644764990448822 3.278991883201156e-08 5.603515094364169e-09 0.1592536913434613 0.05308456180360204 1.32205973315372e-10 9.878748922162792 -0.31233595375039647 LLELGQK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLELGQKQR 9 1 E9PP05;Q86TE4-3;Q86TE4-2;Q86TE4 E9PP05 LUZP2 Leucine zipper protein 2 1 35651100.0 7577100.0 10616000.0 17458000.0 True False 10378558.63342823 10146950.01758258 13334779.958796185 1.0 0.9776839324200892 1.2848392951065748 23.307102761395296 -6.88942655397155 1.0257464046274003 0.9832686261063983 1.310964819232017 0.9805295198539378 0.019511631731335997 0.11961055816079628 0.22456406882144914 0.014504194344691876 0.03608612454298304 1.2899516905755348e-07 6.88942655397155 0.3276961931256186 LLELGQK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLELGQKQR 9 1 E9PP05;Q86TE4-3;Q86TE4-2;Q86TE4 E9PP05 LUZP2 Leucine zipper protein 2 1 70442000.0 26223000.0 25842000.0 18377000.0 True False 21805586.37587167 25702784.016764607 22219545.734352298 1.0 1.1787247347406933 1.018984096613824 24.378194450787333 -10.748538962869452 2.6095369326340756 0.9782051709338088 1.098854415579211 0.33802121426099263 0.0652138466035564 14480336.621982584 11069722.051240273 2036869.1498821005 0.023337649627427542 1.7842719048303376e-11 10.748538962869452 0.12064924464540228 LLELGQK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLELGQKQR 9 1 E9PP05;Q86TE4-3;Q86TE4-2;Q86TE4 E9PP05 LUZP2 Leucine zipper protein 2 1 31694500.0 10731000.0 14604000.0 6359500.0 True False 13891491.039633872 13791274.562052263 5202136.253980387 1.0 0.9927857652360225 0.37448364895734737 23.727698123144716 -6.909446983269955 0.8994785686517829 1.0194806452165106 0.2955128442260881 0.9907114289662536 0.028256417990030626 0.10478551014797295 0.140754376124739 0.023070776408557606 0.06344552430879456 1.2318363536366002e-07 6.909446983269955 -0.7239678009904225 down LLELLTK(ub)LGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLELLTKLGR 10 1 H0Y4G9;Q99836-5;Q99836;Q99836-6;A0A3F2YP85;A0A494C0J8;A0A0A0MSI9;Q99836-3;Q99836-2;A0A3B3ITY3;Q99836-4 H0Y4G9 MYD88 Myeloid differentiation primary response protein MyD88 1 1939900.0 453050.0 901420.0 585430.0 True False 593952.9373424406 766931.6497076404 524855.3194410959 1.0 1.291233027887982 0.8836648266939932 19.17998909611511 -6.714881460855494 1.7778536666448024 1.1781469880097624 0.8844808381617792 0.4881893984405069 0.12263525575865958 0.36536706938263236 2.2540407670773406 0.054833048119321756 0.13848080763227782 1.9280510961128087e-07 6.714881460855494 -0.2936661498479831 LLELLTK(ub)LGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLELLTKLGR 10 1 H0Y4G9;Q99836-5;Q99836;Q99836-6;A0A3F2YP85;A0A494C0J8;A0A0A0MSI9;Q99836-3;Q99836-2;A0A3B3ITY3;Q99836-4 H0Y4G9 MYD88 Myeloid differentiation primary response protein MyD88 1 4670200.0 1151300.0 1120100.0 2398800.0 True False 1114752.6116897573 1567361.771244336 1770482.3175425462 1.0 1.4060175816663998 1.5882289029660355 20.088292148987158 -11.510867962701013 0.14081963292785848 9.111112449377278e-20 1.848531879157689 0.9996702731489117 0.004464581221714896 4.304652271034507 0.09049575895815155 1.5150798075837129 0.1916630355274705 3.0841254654988903e-12 11.510867962701013 1.848531879157689 LLELLTK(ub)LGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLELLTKLGR 10 1 H0Y4G9;Q99836-5;Q99836;Q99836-6;A0A3F2YP85;A0A494C0J8;A0A0A0MSI9;Q99836-3;Q99836-2;A0A3B3ITY3;Q99836-4 H0Y4G9 MYD88 Myeloid differentiation primary response protein MyD88 1 20806900.0 3492700.0 6334200.0 10980000.0 True False 5298681.250572846 5203812.520669516 8809798.187295036 1.0 0.9820957847024533 1.6626397721777657 22.337201912019772 -6.900861617224753 0.955838891795226 0.9723697440526425 1.7353286671462045 0.9869888780542255 0.03612203968226564 0.1107733890146251 0.1738801863699659 0.028297664203427348 0.0739462993978429 1.2564302464846965e-07 6.900861617224753 0.762958923093562 LLELLTK(ub)LGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLELLTKLGR 10 1 H0Y4G9;Q99836-5;Q99836;Q99836-6;A0A3F2YP85;A0A494C0J8;A0A0A0MSI9;Q99836-3;Q99836-2;A0A3B3ITY3;Q99836-4 H0Y4G9 MYD88 Myeloid differentiation primary response protein MyD88 1 4860000.0 1151300.0 1663800.0 2044900.0 True False 957356.9612378833 1654836.7791615576 2472479.135450677 1.0 1.7285472881732826 2.5826094503493326 19.868697424421434 -6.969030113006472 0.2803893832738877 0.8127259219841707 3.5244696159680067 0.9999737962631124 0.0033108071533353026 0.07661872516962415 0.010151964676972183 0.015740242514463137 0.07835370458743407 1.0739149469029996e-07 6.969030113006472 2.711743693983836 LLELLTK(ub)LGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLELLTKLGR 10 1 H0Y4G9;Q99836-5;Q99836;Q99836-6;A0A3F2YP85;A0A494C0J8;A0A0A0MSI9;Q99836-3;Q99836-2;A0A3B3ITY3;Q99836-4 H0Y4G9 MYD88 Myeloid differentiation primary response protein MyD88 1 23444700.0 3492700.0 3912000.0 16040000.0 True False 4521369.001409857 3694293.7610756285 13120884.584298346 1.0 0.8170741560628365 2.9019716329737704 22.10832823411222 -6.885518916103387 1.0484922833114823 0.8756495309104034 3.0663290718339917 0.977873053782014 0.1402243853932935 0.1228557809065824 0.24367164045826528 0.10245175172605628 0.2516305793877224 1.3016106214734825e-07 6.885518916103387 2.1906795409235884 up LLELLWNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLELLWNK 8 0 Q92905;E5RHH5 Q92905 COPS5 COP9 signalosome complex subunit 5 0 4799270.0 594870.0 1656300.0 2548100.0 False True 814809.5147572889 1583119.189348343 1946291.2597667892 1.0 1.942931643133689 2.3886457196643565 19.636103301590158 -9.693426696773708 0.19723106437462667 6.903080705696439e-23 2.8176267420011714 0.9994712158721062 0.013311962273866187 1.1444970050610956 0.08344602214378995 0.9173273174884451 0.2668407864482692 2.02569148819093e-10 9.693426696773708 2.8176267420011714 LLENK(ub)MNSDEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLENKMNSDEIK 12 1 Q9H089 Q9H089 LSG1 Large subunit GTPase 1 homolog 1 14286800.0 4274000.0 3907000.0 6105800.0 True False 6483970.471253858 3209765.3244696744 4898985.953732786 1.0 0.4950308362291132 0.7555534028805392 22.628446089995695 -10.0675095390551 4.995891504052446 1.0000082237828398 0.625292119552758 0.7339187416907453 0.10635789246987337 147592250.45069504 19.27238169189986 13962.518411046345 0.03640913554544544 8.560329091906875e-11 10.0675095390551 -0.37471610423008184 LLENK(ub)MNSDEIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLENKMNSDEIK 12 1 Q9H089 Q9H089 LSG1 Large subunit GTPase 1 homolog 1 12695000.0 4274000.0 4519500.0 3901500.0 True False 5532777.25313532 4267985.852040203 3191467.032770574 1.0 0.7714002673108911 0.5768291197629599 22.399572412088144 -6.972995750970381 0.1721978793594124 1.1669034990705116 0.17610434289362656 0.9999973098193257 0.0002836014463235194 0.07534213740858504 0.005383985593945332 0.008036449136256197 0.022379417193496468 1.0641534295869068e-07 6.972995750970381 -0.9907991561768851 LLENPTINHQK(ub)NRPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLENPTINHQKNRPTR 16 2 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 5216600.0 1252500.0 1429700.0 2534400.0 True False 1642039.6292272545 1216394.3329269509 2272164.599681454 1.0 0.7407825677748029 1.3837452880176446 20.64705751507553 -6.797258046147218 1.4669723656628995 0.8564791756474938 1.3920437465592326 0.8240693796150395 0.11078455146340294 0.22468616328220933 0.9548427629505349 0.05941774110045212 0.13842765468133716 1.5949312002482754e-07 6.797258046147218 0.5355645709117388 LLENPTINHQK(ub)NRPTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLENPTINHQKNRPTR 16 2 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 92258100.0 1136100.0 19212000.0 71910000.0 True False 1723546.7600354496 15783468.495958868 57696956.98072731 1.0 9.157551661455496 33.47571317388604 20.716949009054098 -6.951592827684819 0.541073131237152 0.6444794798483597 43.11386866868891 0.9993204357304271 0.35960091499856356 0.0828523600600718 0.03336342391239703 0.39493994924811243 2.0142367831698205 1.1179108527072474e-07 6.951592827684819 42.46938918884055 LLENPTINHQK(ub)NRPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLENPTINHQKNRPTR 16 2 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 5384310.0 1252500.0 932210.0 3199600.0 True False 1715583.0975398063 891021.8797937694 2443920.3778304677 1.0 0.5193697006408605 1.4245421171000794 20.710267576598422 -6.7624402005179185 1.6031355453371723 0.7216699144687778 1.4282700391468528 0.700886844017404 0.20223260747478586 0.27884743535869966 1.4129460116010537 0.09950309966201953 0.2385633164839285 1.7280639071149185e-07 6.7624402005179185 0.706600124678075 LLENPTINHQK(ub)NRPTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLENPTINHQKNRPTR 16 2 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 101319700.0 1136100.0 19250600.0 80933000.0 True False 1470703.8458790453 18179287.18736257 66204024.44270697 1.0 12.3609435293866 45.015197742368436 20.488075331146547 -6.952409517572146 0.5317379643812408 0.4913337167342831 58.37158589595006 0.9993770351792417 0.4656617147358588 0.08253247032901716 0.032068547608329105 0.5181935522699109 2.7009494669497327 1.1158105990094121e-07 6.952409517572146 57.88025217921578 LLENSEHQSIK(ub)HVGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLENSEHQSIKHVGSK 16 1 O94986;O94986-3 O94986 CEP152 Centrosomal protein of 152 kDa 1 5223400.0 1671900.0 2210000.0 1341500.0 True False 2191877.090702632 1880276.6145125278 1202694.448576651 1.0 0.8578385268444879 0.5487052415841042 21.06373547090486 -6.958376084891231 0.4577456740100814 1.0092164081387576 0.38491259154825214 0.9997051485958276 0.003235001303267262 0.080286391905058 0.02331380137010239 0.004182535536650565 0.025544060427916 1.1005858252415358e-07 6.958376084891231 -0.6243038165905055 LLENSEHQSIK(ub)HVGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLENSEHQSIKHVGSK 16 1 O94986;O94986-3 O94986 CEP152 Centrosomal protein of 152 kDa 1 17982400.0 3357500.0 5098900.0 9526000.0 True False 5093572.966128873 4188961.4571124674 7643181.924605871 1.0 0.8224013840516529 1.5005541248611398 22.280246581650687 -6.837131601629302 1.2957621565622002 0.9054615035945272 1.5216065991070333 0.9193893856122498 0.08152165000639552 0.17217711238272942 0.562804372039209 0.04935652323781809 0.11362847105030312 1.455018108438465e-07 6.837131601629302 0.6161450955125062 LLENSEHQSIK(ub)HVGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLENSEHQSIKHVGSK 16 1 O94986;O94986-3 O94986 CEP152 Centrosomal protein of 152 kDa 1 12764000.0 3357500.0 6425100.0 2981400.0 True False 4346349.936219423 6067537.536883187 2438815.7917473246 1.0 1.396007598541617 0.5611181399417358 22.051372903743136 -6.777716803563821 1.5447368809060333 1.2248922140703367 0.5549677592850372 0.759248709321117 0.16731252905590635 0.2541320892671099 1.1976137994400724 0.08532205824644587 0.20171434261989588 1.668334752147899e-07 6.777716803563821 -0.6699244547852995 LLENSTLNSK(ub)LLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLENSTLNSKLLK 13 1 Q6JHV3;H0YMI4;Q9Y6I4;H0YLB7;H0YKU8;Q9Y6I4-2;H0YL81;H0YLG0 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 1 8129700.0 2497000.0 1970800.0 3661900.0 True False 2417734.1017886964 2757750.717586232 2702738.5353547833 1.0 1.1406344128355486 1.117880801431073 21.205224157532204 -10.037914352404352 4.234948383314063 0.9999894946389579 1.129257607167797 0.9772871270638767 0.00928912308400748 6477086.720320737 5793663.705587002 814.0497044537443 0.003399471353678701 9.164011965864279e-11 10.037914352404352 0.12926811252883919 LLENSTLNSK(ub)LLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLENSTLNSKLLK 13 1 Q6JHV3;H0YMI4;Q9Y6I4;H0YLB7;H0YKU8;Q9Y6I4-2;H0YL81;H0YLG0 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 1 6554200.0 2497000.0 2835300.0 1221900.0 True False 2076366.1358559858 2820025.676137015 1477393.64057273 1.0 1.3581543386973292 0.7115284800017564 20.98562943296648 -6.756364258985519 1.6262858871242014 1.208973134985537 0.7095903284322218 0.6759194380461099 0.15057153929718886 0.28905811149762095 1.5059035199818358 0.07308384953704483 0.1762592307860309 1.7524100735652363e-07 6.756364258985519 -0.49938280655331524 LLEPLVTQVTTLVNTNSK(ub)GPSNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLEPLVTQVTTLVNTNSKGPSNK 23 1 P35221;P35221-2;G3XAM7;E5RIB1;E5RHV7;E5RGY6;E5RG03;E5RFM3;E5RJL0;E5RIE0 P35221 CTNNA1 Catenin alpha-1 1 25168400.0 3554400.0 6905000.0 14709000.0 True False 3441567.5175801935 9662202.509099295 10856271.639458613 1.0 2.8075004949758777 3.154455515982957 21.714634382726633 -10.110132759107923 0.38269340478855746 1.1142505314175519e-14 3.2010589449692763 0.9989559972680521 0.030518513625452343 1.4702656549111122 0.1737514651188717 1.6968100670222799 0.09258178813360236 7.760098625778005e-11 10.110132759107923 3.2010589449692652 LLEPLVTQVTTLVNTNSK(ub)GPSNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLEPLVTQVTTLVNTNSKGPSNK 23 1 P35221;P35221-2;G3XAM7;E5RIB1;E5RHV7;E5RGY6;E5RG03;E5RFM3;E5RJL0;E5RIE0 P35221 CTNNA1 Catenin alpha-1 1 19442400.0 3554400.0 9401600.0 6486400.0 True False 2955641.0866185487 9350951.71472852 7842676.250274962 1.0 3.1637642868967673 2.6534602884572527 21.49503965816091 -10.324283192742639 5.879435287187143 0.9997968183538006 2.908612287677015 0.9491135728375453 0.20833073497982252 0.0005549041935086211 6.377474211762322e-05 0.2017352930521555 0.06723845558999778 4.739328445363513e-11 10.324283192742639 1.9088154693232142 LLEPVLLLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLEPVLLLGK 10 0 P62249;M0R210;M0R3H0;M0R1M5;Q6IPX4;M0QX76 P62249 RPS16 40S ribosomal protein S16 0 35044500.0 7448500.0 14985000.0 12611000.0 False True 9765055.631376605 12749296.411072508 11306134.693253934 1.0 1.3056040735812178 1.1578156971195952 23.21919683247183 -10.167809226927794 4.246280767600097 0.9999364828479764 1.2317098853180468 0.7662204822888501 0.060334352150525725 42279888.19754918 3.582098856517482 28027.177374255007 0.02065405352404202 6.795020527726994e-11 10.167809226927794 0.2317734024700704 LLEPVLLLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLEPVLLLGK 10 0 P62249;M0R210;M0R3H0;M0R1M5;Q6IPX4;M0QX76 P62249 RPS16 40S ribosomal protein S16 0 25523400.0 12678000.0 6075000.0 6770400.0 False True 12275543.829586327 8500779.180706495 4997029.1323537 1.0 0.6924971552150747 0.4070719148352464 23.549283604260086 -7.143581625201093 0.22118979654840332 1.1401799571541351 9.51012395712164e-15 0.9999865200908252 0.0008889166690862697 0.0820753454640877 0.009211753749929998 0.010694409855092988 0.03335074449259006 7.184861069648073e-08 7.143581625201093 -1.1401799571541256 down LLEPVLLLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLEPVLLLGK 10 0 P62249;M0R210;M0R3H0;M0R1M5;Q6IPX4;M0QX76 P62249 RPS16 40S ribosomal protein S16 0 39647500.0 7448500.0 13787000.0 18412000.0 False True 10202411.738143904 13177844.752487853 14063464.807042953 1.0 1.29164016221965 1.3784451331701968 23.28240689399472 -12.894938353114844 0.1843652286610486 9.554297865246273e-09 1.4478151259259562 0.999465452744239 0.0037424172944270323 7.882585272820429 0.12788362156020253 2.928129660036568 0.06231523075515323 1.273683864042181e-13 12.894938353114844 1.4478151163716584 LLEPVLLLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLEPVLLLGK 10 0 P62249;M0R210;M0R3H0;M0R1M5;Q6IPX4;M0QX76 P62249 RPS16 40S ribosomal protein S16 0 18270700.0 12678000.0 2937800.0 2654900.0 False True 10542318.73062962 2921973.4882923593 3210027.3151293453 1.0 0.2771661114554303 0.3044896855378639 23.329688879694363 -10.60734295093643 6.464813348695599 1.0020525659021502 0.29082789849665386 0.9988878846000003 0.011154802408516223 0.00033064764888677823 2.0082707408434733e-05 0.010821716381633083 0.003600196996534811 2.469773059892629e-11 10.60734295093643 -0.7112246674054963 LLEPVLLLGK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLEPVLLLGKER 12 1 P62249;M0R210;M0R3H0;M0R1M5;Q6IPX4;M0QX76 P62249 RPS16 40S ribosomal protein S16 1 8425500.0 2300700.0 2461900.0 3662900.0 True False 2227665.537839508 3444949.508638895 2703476.605355425 1.0 1.546439288179663 1.2135917889978134 21.087101211731994 -10.104886546845712 4.396473187224494 0.9999581708797113 1.3800155386136794 0.6347704795618543 0.13588442261893363 94633063.85404274 3.356763825991447 42249.367471827485 0.04651685216239474 7.854407928626793e-11 10.104886546845712 0.38005736773396814 LLEQFVCAHTGIIFYAPYTGVCVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLEQFVCAHTGIIFYAPYTGVCVK 24 0 Q9Y676 Q9Y676 MRPS18B 28S ribosomal protein S18b, mitochondrial 0 95755000.0 26969000.0 31876000.0 36910000.0 False True 40913944.69799846 26187478.75167523 29614722.321772266 1.0 0.6400624272476064 0.7238295534779134 25.28608930488125 -9.693842378677118 12.748688995527925 1.0000002282026315 0.6819459918658842 0.9505483300529871 0.03419778608084728 0.0 0.0 0.03311186399195668 0.011037287997318892 2.023753539450525e-10 9.693842378677118 -0.31805423633674723 LLEQFVCAHTGIIFYAPYTGVCVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLEQFVCAHTGIIFYAPYTGVCVK 24 0 Q9Y676 Q9Y676 MRPS18B 28S ribosomal protein S18b, mitochondrial 0 64227000.0 26969000.0 18150000.0 19108000.0 False True 34911902.13846666 17139936.544867747 15630540.064636724 1.0 0.49094822954325956 0.44771379120631377 25.0572156269737 -13.999999999999998 0.3492632495216492 7.231820226948876 0.44168221691009435 0.9997533028606584 0.003938921871241524 20.586699024657 0.1901908743162559 95.14831326724371 0.01293210110537693 1.0000000000000041e-14 13.999999999999998 -6.790138010038781 LLEQWEKDDDIEEGDLPEHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLEQWEKDDDIEEGDLPEHK 20 1 Q14696 Q14696 MESDC2 LDLR chaperone MESD 0 6911220.0 2744300.0 935520.0 3231400.0 False True 2657183.698653872 1309078.0146723494 2384999.4000779507 1.0 0.49265619660978943 0.8975666233712747 21.341466538204877 -9.925230517338724 6.75463173396165 1.000000016767531 0.6951114099905301 0.43051339719981974 0.1653039895163819 4.181169604190316e-08 6.355649899365293e-09 0.1600549091546474 0.053351633204880886 1.1878715547367596e-10 9.925230517338724 -0.3048886067770008 LLEQYK(ub)EESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLEQYKEESK 10 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 3974460.0 913560.0 1804000.0 1256900.0 True False 1197686.0069276248 1534850.231936923 1126848.0450361485 1.0 1.2815130368553038 0.9408543128317963 20.19181830080362 -6.687267051402817 1.8765970561568648 1.17694309452261 0.9420829236657531 0.35752480066495373 0.11912719992893243 0.42252876539974227 2.882876309049164 0.05083001326291752 0.13279969335666406 2.054626799818168e-07 6.687267051402817 -0.23486017085685695 LLEQYK(ub)EESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLEQYKEESK 10 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 3304400.0 913560.0 944740.0 1446100.0 True False 1251327.8200307104 902998.2629626007 1104560.9633643706 1.0 0.7216320523749237 0.8827111055017239 20.255028362326513 -10.2053099269758 5.177324629025579 1.0000152026628322 0.8021715792656887 0.667897650022147 0.06576024806886273 1.154051657687805e-05 1.7713725598042525e-06 0.06367697701024308 0.02122402880105342 6.232898763620606e-11 10.2053099269758 -0.19784362339714345 LLEQYK(ub)EESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLEQYKEESK 10 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 3843540.0 1221700.0 1851300.0 770540.0 True False 1015897.6804866873 1841326.6794457214 931656.3514255767 1.0 1.812511943686686 0.9170769550130747 19.95432367292244 -6.667767260639982 1.9449383440199697 1.5195960690578794 0.9206988371478235 0.26938733267870074 0.34531219165588745 0.4662357982179125 3.3979059583259783 0.1430310349295129 0.3833078960283566 2.1489818096399397e-07 6.667767260639982 -0.5988972319100558 LLEQYK(ub)EESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLEQYKEESK 10 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 9595100.0 2144200.0 2841900.0 4609000.0 True False 2775709.168500877 2683745.7667691233 3770209.29233361 1.0 0.9668685023721625 1.3582868605682665 21.40442498337073 -6.88632702569932 1.0438351489068871 0.9770798452664081 1.389629842667182 0.9784425219261903 0.026020869053901406 0.12217516651380521 0.23964550405634147 0.019079095859463657 0.04697842512128981 1.2991909130057332e-07 6.88632702569932 0.4125499974007739 LLEQYK(ub)EESKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLEQYKEESKK 11 2 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 3859100.0 1398800.0 1386200.0 1074100.0 True False 1833840.3459984693 1179384.363365278 962962.4354947321 1.0 0.6431227047320414 0.5251070179560418 20.806436612803314 -13.999999999999998 0.15465331278306724 2.739187228658121 0.40196470391960853 0.9995514579690953 0.0042756481209381535 11.978318873948568 0.12407365967926634 6.253406231657778 0.11152874151671537 1.0000000000000041e-14 13.999999999999998 -2.3372225247385128 LLEQYK(ub)EESKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLEQYKEESKK 11 2 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 21806900.0 3980000.0 4100900.0 13726000.0 True False 5152188.457528907 3872681.3100191825 11228008.840653326 1.0 0.751657541633599 2.179269825474999 22.296753934859343 -6.8620353499007685 1.1755120828003833 0.8644777957583828 2.251103837982717 0.9560609334722017 0.13053996985441998 0.14471376617136372 0.3788463713557674 0.08654367780897743 0.2024900685942782 1.3739301378311813e-07 6.8620353499007685 1.3866260422243344 up LLEQYKEESK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLEQYKEESKK 11 2 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 6744200.0 2835200.0 1987600.0 1921400.0 True False 3883450.0583990826 1899781.2598857505 1467604.8924751405 1.0 0.48919935400660675 0.37791264736391317 21.888907482183505 -13.999999999999934 0.2141528945597351 4.005738461564243 0.31494427128117397 0.9994927462860012 0.006100424773605866 12.84712971750992 0.14664700598518599 16.281015312607256 0.06405389343334233 1.0000000000001513e-14 13.999999999999934 -3.6907941902830688 LLEQYKEESKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLEQYKEESKK 11 2 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 5737210.0 1699100.0 682810.0 3355300.0 False True 1645163.000540319 955459.5938071108 2476446.2731576264 1.0 0.5807689532850607 1.5052893071047004 20.649799100653155 -6.783410319768688 1.5224790994843693 0.7636742449213334 1.5134259585124357 0.7793135779475204 0.17756400178896292 0.24530659314594494 1.1232659368564084 0.09183757802925747 0.21609824794167073 1.646605949365541e-07 6.783410319768688 0.7497517135911023 LLESLEEQEVK(ub)GFNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLESLEEQEVKGFNR 15 1 J3KP26;Q86W74;Q86W74-1 J3KP26 ANKRD46 Ankyrin repeat domain-containing protein 46 1 13588600.0 2860600.0 6167100.0 4560900.0 True False 2769791.818813272 8629655.191001646 3366263.4659328875 1.0 3.115633143395974 1.2153489092819894 21.401346114821575 -6.6204752221395475 2.1154403474620653 2.4033295836150628 1.2226790267428007 0.08428905904685635 0.9096889425790161 0.5840899442740035 4.9677532248678435 0.35330104914308974 1.0083686703928674 2.396209457100466e-07 6.6204752221395475 -1.180650556872262 LLESLEEQEVK(ub)GFNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLESLEEQEVKGFNR 15 1 J3KP26;Q86W74;Q86W74-1 J3KP26 ANKRD46 Ankyrin repeat domain-containing protein 46 1 9815100.0 2860600.0 5117000.0 1837500.0 True False 2378715.646067132 5089433.705355028 2221712.754359929 1.0 2.1395721316121508 0.9339967801671525 21.18175139025585 -6.6588547965394245 1.976646853794035 1.7341988140888334 0.9389979034919764 0.2309036642795691 0.48533284719569103 0.4871436923820669 3.657572064251338 0.1984400786443907 0.5380542546506846 2.1935382076164308e-07 6.6588547965394245 -0.7952009105968569 LLETCSIALVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLETCSIALVGK 12 0 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ISY3 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 9932500.0 2555200.0 3897400.0 3479900.0 False True 3349891.9445920005 3315923.1119462103 3119833.329557878 1.0 0.9898597228783368 0.9313235713750336 21.67568312951683 -6.936660096573051 0.6899560717285607 1.0007102301038893 0.9169782422778727 0.9976925647695504 0.0014539697932683855 0.08932427536135837 0.061804015047663835 0.0013817724814828667 0.005116618783526624 1.1570174352085362e-07 6.936660096573051 -0.08373198782601654 LLEVDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLEVDLK 7 0 A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247;Q13247-2 A0A590UJK4 SRSF6 Serine/arginine-rich splicing factor 6 0 4544100.0 1239200.0 1739200.0 1565700.0 False True 1624603.2004298714 1479718.139348502 1403696.3832549115 1.0 0.9108181856080102 0.8640241400998669 20.631655960895166 -13.999999993520806 0.08116251040493572 1.4775749495820638 0.7272432011179983 0.9998818234601807 0.000613133243669957 12.247071398434262 0.08049488162538916 1.0445963324083167 0.12404345002456979 1.0000000149188958e-14 13.999999993520806 -0.7503317484640655 LLEVDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLEVDLK 7 0 A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247;Q13247-2 A0A590UJK4 SRSF6 Serine/arginine-rich splicing factor 6 0 14485300.0 1950000.0 9748000.0 2787300.0 False True 2958292.564095702 8008393.238528375 2236388.9332830105 1.0 2.707099810115096 0.755972874497163 21.496333305972858 -6.675529114303574 1.9176156786608516 2.0844075820636347 0.7636160954258535 0.30381818949768247 0.7242279392833044 0.4485536350805147 3.1849627738399633 0.30347333991703895 0.8050504302841068 2.1109156791590839e-07 6.675529114303574 -1.3207914866377812 LLEVDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLEVDLK 7 0 A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247;Q13247-2 A0A590UJK4 SRSF6 Serine/arginine-rich splicing factor 6 0 7583100.0 1239200.0 3747400.0 2596500.0 False True 1697365.7281208208 3581827.4770053653 1983260.1765960772 1.0 2.110227287887367 1.16843420586309 20.694866022418058 -6.605939436502439 2.1683477992008338 1.7437474022422488 1.1716577820949021 0.03803850222881311 0.47914787348209137 0.6239754276333966 5.553099388126797 0.18284108579214023 0.5324368374483394 2.477767564687399e-07 6.605939436502439 -0.5720896201473467 LLEVDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLEVDLK 7 0 A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247;Q13247-2 A0A590UJK4 SRSF6 Serine/arginine-rich splicing factor 6 0 7799900.0 1950000.0 3193700.0 2656200.0 False True 2524313.4402465792 3015967.787512075 2172798.8549135467 1.0 1.194767551218786 0.8607484396633819 21.267459628065307 -6.748642551231114 1.654810211660196 1.1147129682794954 0.8601510245799697 0.6431074107277306 0.08183796655901214 0.30243208914357717 1.6290086633068237 0.039073530751601394 0.0949977275363613 1.7838463692319383e-07 6.748642551231114 -0.2545619436995257 LLEVEHPAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLEVEHPAAK 10 0 P17987;E7ERF2;F5H136;F5H676;F5H726;F5GZI8 P17987 TCP1 T-complex protein 1 subunit alpha 0 10406760.0 254160.0 5942100.0 4210500.0 False True 333206.22128894104 5055561.8421243895 3774837.8499679393 1.0 15.17247133792391 11.328833643518841 18.346055811931727 -9.9275115519063 7.5965086603395795 0.9999999180548554 13.250652490721379 0.9312468609075615 1.5691585179033445 2.3169991556409706e-06 3.099501639303676e-07 1.5193312018461906 0.5064437339499287 1.1816488811560186e-10 9.9275115519063 12.250652572666523 LLEVEHPAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLEVEHPAAK 10 0 P17987;E7ERF2;F5H136;F5H676;F5H726;F5GZI8 P17987 TCP1 T-complex protein 1 subunit alpha 0 9015620.0 2520600.0 563220.0 5931800.0 False True 2440584.932706685 788116.6831534986 4378083.629814448 1.0 0.3229212278547719 1.7938665322165275 21.218795527924303 -6.781519041461054 1.5297232590448542 0.6173851045096975 1.806130877327018 0.7728226392430321 0.286522827685075 0.24820955516236576 1.1472916478130792 0.14750345855260413 0.3476403022395308 1.6537922733468595e-07 6.781519041461054 1.1887457728173203 LLEVEHPAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLEVEHPAAK 10 0 P17987;E7ERF2;F5H136;F5H676;F5H726;F5GZI8 P17987 TCP1 T-complex protein 1 subunit alpha 0 9388460.0 254160.0 4607400.0 4526900.0 False True 348129.820415742 4403829.83336567 3457739.4544320353 1.0 12.649964395772097 9.932327688282347 18.40926587345462 -9.898753126185333 7.145763371475486 0.9999998609378628 11.291146042027254 0.9502977247492901 1.1094705399346452 2.4450785853263993e-06 3.9426258151817127e-07 1.074240231062898 0.3580800770228693 1.2625450217932728e-10 9.898753126185333 10.291146181089392 LLEVIILQCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLEVIILQCK 10 0 O95373;O15397;O15397-2 O95373;O15397 IPO7;IPO8 Importin-7;Importin-8 0 27971300.0 5389300.0 14397000.0 8185000.0 False True 8175962.110605621 11827742.865725579 6567231.162387059 1.0 1.4466484440262968 0.8032364966403449 22.962957079815947 -6.720005654100878 1.7593539971059824 1.2717346335476316 0.8042433040613959 0.5125180708515316 0.1879511358219094 0.35530634578466913 2.1493648273042596 0.08482521532628215 0.21293684697897075 1.9054359108394267e-07 6.720005654100878 -0.46749132948623573 LLEVIILQCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLEVIILQCK 10 0 O95373;O15397;O15397-2 O95373;O15397 IPO7;IPO8 Importin-7;Importin-8 0 5957860.0 756760.0 2273800.0 2927300.0 False True 1036554.6226700387 2173335.9975489145 2235932.0296359304 1.0 2.0966922051349934 2.157080756512803 19.98336471257209 -10.881520491453315 0.5218490592838986 5.263087460627823e-15 2.153341167849645 0.9997945940397506 0.007621623685330361 2.57746448988398 0.25316406381616846 3.1758166656707627 0.011801913025534534 1.3136495111591707e-11 10.881520491453315 2.1533411678496397 LLEVQGSRPGK(ub)NVQLTENEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLEVQGSRPGKNVQLTENEIR 21 2 P62136;E9PMD7 P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase 1 13864600.0 2865400.0 6545400.0 4453800.0 True False 3756567.1485730726 5568851.833769363 3992963.499866344 1.0 1.482431063659992 1.0629288235625087 21.840983459968964 -11.973753488082759 11.944881348036061 1.02812901162248 1.2454108712640848 0.0 0.22338663423990635 0.0 0.0 0.0 0.06216941408372282 1.0622983622320004e-12 11.973753488082759 0.21728185964160485 LLEVQGSRPGK(ub)NVQLTENEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLEVQGSRPGKNVQLTENEIR 21 2 P62136;E9PMD7 P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase 1 29995900.0 8585200.0 7569700.0 13841000.0 True False 8312667.525300895 10592320.68546402 10215626.878900442 1.0 1.274238462349739 1.2289228274567214 22.98688007977098 -10.099208405124957 4.80882619643464 0.9999882800257568 1.2515806449056284 0.9762446379622751 0.018500030484617302 2.324674874657006e-06 4.35428800577433e-07 0.017913411604362994 0.005970859163097016 7.957773886580883e-11 10.099208405124957 0.2515923648798716 LLEVQGSRPGK(ub)NVQLTENEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLEVQGSRPGKNVQLTENEIR 21 2 P62136;E9PMD7 P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase 1 163958000.0 10793000.0 19875000.0 133290000.0 True False 16373770.073992273 16328150.96591622 106945173.07691768 1.0 0.9972138910055593 6.531493516376353 23.964883205988755 -6.906778874910685 0.9173721646525277 0.8107070365075792 7.199580287090845 0.9896486446128407 0.26536531727272133 0.10658734113968038 0.15059923290756647 0.21385570643459134 0.5779723383011942 1.2394274919778222e-07 6.906778874910685 6.388873250583266 up LLEVQGSRPGK(ub)NVQLTENEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLEVQGSRPGKNVQLTENEIR 21 2 P62136;E9PMD7 P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase 1 18718600.0 2865400.0 5601200.0 10252000.0 True False 3924815.8145234007 5353720.46330854 7830688.746567687 1.0 1.3640692242162336 1.995173561416814 21.904193521491855 -6.962742289695548 0.3948886337738821 0.9632898203397906 2.4188078625328893 0.9998587767999455 0.004885690828435239 0.07873568248114007 0.017615379348292198 0.008130215207632019 0.0529806027104459 1.0895764561045787e-07 6.962742289695548 1.4555180421930987 LLEVQGSRPGK(ub)NVQLTENEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLEVQGSRPGKNVQLTENEIR 21 2 P62136;E9PMD7 P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase 1 24819700.0 8585200.0 8035900.0 8198600.0 True False 7138974.188846946 7992609.01169874 9912889.353956623 1.0 1.1195738771804788 1.388559349247025 22.767285355205257 -6.957681992874086 0.46695691377153487 0.9926811654865614 1.5264228170065595 0.9996743299748448 0.002932357672455885 0.08053979392096886 0.024271329631903316 0.003698248584900077 0.02220606455971341 1.102346194377435e-07 6.957681992874086 0.5337416515199981 LLEVQGSRPGK(ub)NVQLTENEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLEVQGSRPGKNVQLTENEIR 21 2 P62136;E9PMD7 P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase 1 102069000.0 10793000.0 16712000.0 74564000.0 True False 13971751.261836587 15781962.508971347 60994117.09124827 1.0 1.1295622297599368 4.365531274368721 23.736009528081205 -6.91533607186779 0.8586115875341969 0.915911945133182 4.8352046293091275 0.9927841224733861 0.1322518495278682 0.10099405721211241 0.12041160290086993 0.11121872876430688 0.3196415378656876 1.215245238523864e-07 6.91533607186779 3.9192926841759457 up LLFEGAGSNPGDK(ub)TLEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLFEGAGSNPGDKTLEDR 18 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 12309100.0 3223300.0 2694900.0 6390900.0 True False 4225777.514481598 2292831.4246379235 5729630.973841615 1.0 0.5425821441806785 1.3558761563301338 22.010785381271987 -6.754077197275122 1.6344998421536667 0.7323591948980165 1.3580349025451095 0.6664212074395108 0.19226336987986722 0.2929890886291298 1.5411744254403983 0.0928696489825334 0.22452851128778148 1.761662877198071e-07 6.754077197275122 0.625675707647093 LLFEGAGSNPGDK(ub)TLEDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLFEGAGSNPGDKTLEDR 18 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 92891700.0 5423700.0 31368000.0 56100000.0 True False 8228149.425582484 25770135.32069736 45011810.41049654 1.0 3.1319479007727242 5.47046584625073 22.972136563185728 -6.9699374992214995 0.2596746862128985 0.34084611859915787 8.330918487439714 0.9999818912102475 0.007769198936054599 0.07632300576772316 0.009102690697216021 0.04891990349511335 0.22075066320542006 1.0716735222787466e-07 6.9699374992214995 7.990072368840556 LLFEGAGSNPGDK(ub)TLEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLFEGAGSNPGDKTLEDR 18 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 16560900.0 3223300.0 2380600.0 10957000.0 True False 4415041.116407224 2275417.22040854 8369182.266498445 1.0 0.5153784892178263 1.8956068688458638 22.073995442794878 -6.811845570506743 1.406928519130266 0.7364599376095959 1.9207489094599315 0.8645535418676169 0.21041849481238434 0.20429384843822115 0.7966852982037084 0.11759176656236207 0.27177223550145874 1.5422487591437208e-07 6.811845570506743 1.1842889718503355 LLFEGAGSNPGDK(ub)TLEDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLFEGAGSNPGDKTLEDR 18 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 98955700.0 5423700.0 17681000.0 75851000.0 True False 7021086.567110441 16697036.807151869 62046896.29698343 1.0 2.3781271812496123 8.83722137647978 22.743262885278178 -6.941257700626446 0.6477572807703218 0.9287795122943976 10.645428470147554 0.9983240384279928 0.13985904261143436 0.08719752099323452 0.05203172128198801 0.13747647228413737 0.5529134573376611 1.1448334213275729e-07 6.941257700626446 9.716648957853156 LLFNAGNIANHFFTVPFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLFNAGNIANHFFTVPFLR 19 0 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 0 7287922900.0 3204922900.0 2226600000.0 1856400000.0 False True 4862102350.548742 1829245833.4947972 1489481726.3109736 1.0 0.3762252831408098 0.3063452019151487 32.17893311738065 -13.999999999999998 0.30903289119843463 6.995623921709858 0.29070878284676743 0.9996698683750638 0.005665779081251085 17.20121462973101 0.17684384792712943 66.28087621085879 0.024312391879274014 1.0000000000000041e-14 13.999999999999998 -6.7049151388630905 LLFNAGNIANHFFTVPFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLFNAGNIANHFFTVPFLR 19 0 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 0 9297260000.0 3204922900.0 3240537100.0 2851800000.0 False True 4148835872.5251465 3060198361.7239523 2332801661.939032 1.0 0.737604102873656 0.5622786086544311 31.950059439473097 -8.247652662145965 0.1026971319912785 1.5214689772114662 5.2570011860230555e-12 0.9999835632863496 0.0007292246546628764 0.08502765808513095 0.0208672352687314 0.1454750623921864 0.14774461482723833 5.6538897798784115e-09 8.247652662145965 -1.5214689772062093 LLFNMAGVTFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLFNMAGVTFR 11 0 D6RBJ9;P32321;P32321-2 D6RBJ9 DCTD Deoxycytidylate deaminase 0 5019200.0 1458100.0 2350100.0 1211000.0 False True 1911583.220260488 1999474.2406180531 1085697.3367322597 1.0 1.0459781292417853 0.5679571389961844 20.86633657820385 -6.883303385541758 1.0612311880948364 1.0299573098488095 0.5318625070006447 0.976252712503582 0.03318173226553126 0.12474298385018319 0.25495935732686914 0.024010202112839635 0.05858078985692436 1.308267685807376e-07 6.883303385541758 -0.49809480284816476 LLFNMAGVTFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLFNMAGVTFR 11 0 D6RBJ9;P32321;P32321-2 D6RBJ9 DCTD Deoxycytidylate deaminase 0 5039240.0 2449800.0 1680600.0 908840.0 False True 2372032.439952725 2351672.3442132208 670787.5393844302 1.0 0.9914166031642003 0.2827902047569801 21.177692309662937 -6.909542904292279 0.8988272797418003 1.0222594711195145 0.1920975217179328 0.9907481337340953 0.03232746536013304 0.10472185542815755 0.14040755007765862 0.026407158453789954 0.07266826531889327 1.2315643125225893e-07 6.909542904292279 -0.8301619494015817 down LLFNMAGVTFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLFNMAGVTFR 11 0 D6RBJ9;P32321;P32321-2 D6RBJ9 DCTD Deoxycytidylate deaminase 0 7146800.0 1458100.0 2269800.0 3418900.0 False True 1997198.9736708929 2169512.7307751435 2611426.2344557433 1.0 1.0862777116230609 1.3075443503037096 20.92954663972674 -6.95491275846627 0.5020232090179638 0.9956453740040517 1.4077529883119422 0.9995325416936566 0.0028003868482545887 0.08157097845540094 0.02824713573432631 0.0032717693363533617 0.018253862170443266 1.1093976498504064e-07 6.95491275846627 0.41210761430789045 LLFNMAGVTFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLFNMAGVTFR 11 0 D6RBJ9;P32321;P32321-2 D6RBJ9 DCTD Deoxycytidylate deaminase 0 5045300.0 2449800.0 1308100.0 1287400.0 False True 2037117.2445414495 1301053.005662478 1556589.387734951 1.0 0.6386736007211712 0.7641137945819784 20.958097585097214 -10.387336973053902 5.0698199867403595 1.000233887876296 0.7013936976515471 0.8831161306526557 0.05121074469922628 0.00013548772037096462 1.6372983821548613e-05 0.04962305518941491 0.01652819678056814 4.098859453243468e-11 10.387336973053902 -0.29884019022474884 LLFQNLWKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLFQNLWKPR 10 1 O60573;B8ZZL3 O60573 EIF4E2 Eukaryotic translation initiation factor 4E type 2 0 10659400.0 5587800.0 2089900.0 2981700.0 False True 5410418.347607078 2924407.9686845224 2200703.3209173796 1.0 0.5405142044104465 0.4067528940512904 22.367308720619064 -13.999999999999998 0.17302179903006187 3.336100609366334 0.2924773058248793 0.9995082386521659 0.005634162342840422 12.122324220549382 0.13177518089779017 9.508017039073424 0.10612483645779634 1.0000000000000041e-14 13.999999999999998 -3.0436233035414544 LLFQNLWKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLFQNLWKPR 10 1 O60573;B8ZZL3 O60573 EIF4E2 Eukaryotic translation initiation factor 4E type 2 0 14244500.0 3470200.0 6054200.0 4720100.0 False True 4753226.718628852 5786705.4254378695 3605309.5935109397 1.0 1.2174267645931145 0.7584972918251525 22.180475786037167 -6.777838221140687 1.5440160867221322 1.1234541463510428 0.7550864791075158 0.7597902389785096 0.0918681067058033 0.25393056733989705 1.1955176347744425 0.046867920511351135 0.11080290091922144 1.6678683938171372e-07 6.777838221140687 -0.368367667243527 LLFQNLWKPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLFQNLWKPR 10 1 O60573;B8ZZL3 O60573 EIF4E2 Eukaryotic translation initiation factor 4E type 2 0 11244600.0 5587800.0 2959200.0 2697600.0 False True 4646503.281512244 2943258.2022447875 3261655.6877068486 1.0 0.6334350852512213 0.7019591916967969 22.14771399605334 -10.756256240703129 6.973282485973016 1.0066349855081902 0.6676971384741216 0.9690937940547253 0.02797484931197002 0.0029102799181486535 0.00010172564443423435 0.027317521248328716 0.009028843791493487 1.7528459894622718e-11 10.756256240703129 -0.3389378470340686 LLFSFNMTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLFSFNMTIK 10 0 A0A0J9YY17;A0A1C7CYW8;A0A669KB38;Q8IVF4 A0A0J9YY17 DNAH10 Dynein heavy chain 10, axonemal 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 LLFSFNMTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLFSFNMTIK 10 0 A0A0J9YY17;A0A1C7CYW8;A0A669KB38;Q8IVF4 A0A0J9YY17 DNAH10 Dynein heavy chain 10, axonemal 0 8892400.0 0.0 0.0 8892400.0 False True 0.0 0.0 6792198.264726742 0.0 LLFSFNMTIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLFSFNMTIK 10 0 A0A0J9YY17;A0A1C7CYW8;A0A669KB38;Q8IVF4 A0A0J9YY17 DNAH10 Dynein heavy chain 10, axonemal 0 3787600.0 0.0 3787600.0 0.0 False True 0.0 3767195.447020264 0.0 0.0 LLFSSEK(ub)SSWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLFSSEKSSWR 11 1 Q9H8M7;Q9H8M7-2 Q9H8M7 FAM188A Protein FAM188A 1 10115100.0 3929500.0 3350600.0 2835000.0 True False 3804760.1733995522 4688512.053148177 2092428.451823044 1.0 1.2322753181467923 0.5499501562416377 21.859374088085435 -6.814846240248598 1.3940942701716095 1.1258819670163618 0.5366453784339242 0.8721049403692194 0.10129629693815846 0.20026095513378336 0.7661215761771907 0.05711927564465132 0.13186107060782462 1.5316296313774178e-07 6.814846240248598 -0.5892365885824375 LLFSSEK(ub)SSWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLFSSEKSSWR 11 1 Q9H8M7;Q9H8M7-2 Q9H8M7 FAM188A Protein FAM188A 1 10452900.0 3929500.0 4272900.0 2250500.0 True False 3267553.3563660774 4249881.039595755 2721069.1448636837 1.0 1.3006309541406071 0.8327543112837944 21.63977936351971 -6.7331922907335136 1.7115121061931253 1.1802754140116873 0.83286378182822 0.5739792124019178 0.1263501277015219 0.33031442474776374 1.896967863695426 0.05846716866522192 0.1445652674986854 1.8484500073619997e-07 6.7331922907335136 -0.3474116321834674 LLFSSEK(ub)SSWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLFSSEKSSWR 11 1 Q9H8M7;Q9H8M7-2 Q9H8M7 FAM188A Protein FAM188A 1 21790400.0 7134400.0 7191900.0 7464100.0 True False 9235621.440048823 6791664.4428118095 6105710.388133509 1.0 0.7353770925864093 0.6611044451927246 23.138777608854877 -13.999999999999998 0.17823583431290055 2.365699314695154 0.601018685206496 0.9995003706667493 0.0032510695910793175 12.182389791590937 0.1338162988215862 5.7595305397721335 0.056297215610166394 1.0000000000000041e-14 13.999999999999998 -1.7646806294886581 LLGAALPLLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLGAALPLLTK 11 0 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 0 3225620.0 432460.0 2297800.0 495360.0 False True 566959.2479485966 1954977.1967542493 444104.8990286477 1.0 3.4481793953054938 0.7833100891034632 19.112885514903475 -6.665138081365813 1.9546740878831532 2.56913071408437 0.7942868270739445 0.2577143572538796 1.0411087241441135 0.47234726511205977 3.474489173976539 0.4295245294451953 1.154879291608847 2.1620310094455885e-07 6.665138081365813 -1.7748438870104257 LLGAALPLLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLGAALPLLTK 11 0 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 0 3532060.0 432460.0 983500.0 2116100.0 False True 592352.1487920666 940045.7180004189 1616320.762447509 1.0 1.5869710609092482 2.7286484327667835 19.176095576426366 -6.960586220940855 0.4270914410873756 0.9532267506952089 3.4059647144640812 0.9997913274835626 0.010367924061220187 0.07949236258655352 0.020362434927754046 0.014847688952061006 0.09486032756925979 1.0949991424529295e-07 6.960586220940855 2.452737963768872 LLGALCLQRPPVVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLGALCLQRPPVVSK 15 1 Q9H2W6;H0YN64;A0A087WT90 Q9H2W6 MRPL46 39S ribosomal protein L46, mitochondrial 0 10872300.0 4416300.0 1771200.0 4684800.0 False True 5789812.06751003 1506943.8640835236 4200061.835774803 1.0 0.26027509123134646 0.7254228266481685 22.465085089616135 -10.408166598393256 7.678628483598839 1.000014476664384 0.4928489589430772 0.6131540556074233 0.18989576779705486 4.706312626354812e-05 3.627540271691901e-06 0.18387102125593371 0.06128859551610534 3.90690995251231e-11 10.408166598393256 -0.5071655177213068 LLGELLQDNAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLGELLQDNAK 11 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 29325600.0 2527600.0 11466000.0 15332000.0 False True 3313708.07731322 9755317.494117938 13745591.714928983 1.0 2.9439278495610948 4.148099770476467 21.660015082576678 -8.44043026898733 0.24028679596835367 3.7204212772362436e-17 5.180653602448964 0.9994372962248855 0.0307661559598323 0.14139646378122997 0.06192693737796532 0.5444365382020876 0.47684984195683394 3.6271852023212953e-09 8.44043026898733 5.180653602448964 LLGELLQDNAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLGELLQDNAK 11 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 22190500.0 10623000.0 6223400.0 5344100.0 False True 10285778.679736225 8708436.07460226 3944319.890436522 1.0 0.8466482067865749 0.3834731441584618 23.294147680716065 -6.95129861658439 0.5444003995073652 1.006628650213482 0.20194134574364517 0.9992992918041281 0.006937376756663976 0.08296843754966966 0.033836436541072365 0.007585037028259363 0.038385460383002064 1.118668433629045e-07 6.95129861658439 -0.8046873044698368 down LLGELLQDNAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLGELLQDNAK 11 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 37538600.0 2527600.0 20516000.0 14495000.0 False True 3462122.025821648 19609535.282660507 11071579.5338957 1.0 5.664021988943811 3.1979171881638506 21.72322514409957 -9.62118264420628 8.66486069097205 0.9999943071185252 4.4309695885539115 0.7207305106235251 1.0067830690285222 0.0 0.0 0.9748135148953349 0.32493783829844486 2.392309449923375e-10 9.62118264420628 3.430975281435386 LLGELLQDNAK(ub)LVPVLSAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLGELLQDNAKLVPVLSAK 19 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 37124200.0 5999600.0 8323600.0 22801000.0 True False 9101831.829512075 6838188.54741637 18294372.355966695 1.0 0.7512980546667547 2.0099659825232576 23.1177254998436 -6.855376924021277 1.2088215172599401 0.8663939730592761 2.065764359928676 0.9477763680742721 0.12438065848710103 0.1516392792845349 0.42370223120695316 0.08038815109741078 0.18678445787029083 1.3951569792233886e-07 6.855376924021277 1.1993703868693997 up LLGELLQDNAK(ub)LVPVLSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLGELLQDNAKLVPVLSAK 19 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 27967700.0 5999600.0 5836100.0 16132000.0 True False 7766600.4697965905 5511315.904655789 13196141.528298074 1.0 0.7096175380835744 1.699088498193816 22.88885182193605 -6.828127127344896 1.3361841662201333 0.844621754559434 1.7247228190215267 0.9020838673679008 0.1299468175848572 0.18313913345230506 0.6401220265823103 0.07637110849763745 0.17577674400701732 1.4855007405890518e-07 6.828127127344896 0.8801010644620927 LLGGFQETCSK(ub)AIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLGGFQETCSKAIR 14 1 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 1 8451700.0 3544800.0 2116600.0 2790300.0 True False 4855408.354618042 2023081.6133397957 2131288.608032365 1.0 0.41666559547264787 0.43895146450561023 22.211161205114433 -10.07641060957572 5.80627902546929 1.0000024826947054 0.42780852998912433 0.9988635665709109 0.009098167934413662 2.9239989384014486e-07 4.6516325658076095e-08 0.008809301346211145 0.002936421074218582 8.386666828313572e-11 10.07641060957572 -0.572193952705581 LLGGLAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLGGLAVR 8 0 P23396;P23396-2;E9PL09;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 0 36957100.0 9601800.0 21354000.0 6001300.0 False True 14566632.58560724 17543211.860436503 4815140.424536771 1.0 1.2043423047390043 0.3305596126104283 23.796164067795228 -6.8450888147571884 1.2585295663762435 1.1087438655906534 0.2987963161771845 0.9328572725698732 0.09669933678627439 0.1629386025929483 0.49910283202009204 0.06019189558691339 0.13892146706867298 1.4286017745214518e-07 6.8450888147571884 -0.8099475494134689 down LLGGLAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLGGLAVR 8 0 P23396;P23396-2;E9PL09;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 0 26230600.0 10093000.0 8396300.0 7741300.0 False True 13824654.853069253 8025323.703148875 5912964.377078077 1.0 0.580508069709035 0.4277115370996276 23.720740126734366 -13.999999999987073 0.1404646642078383 3.0046786919234454 0.23967220797789776 0.9996010873890462 0.0048323052253016596 11.934524736556751 0.11745795181557697 6.5559694311065595 0.16815806334611927 1.0000000000297645e-14 13.999999999987073 -2.7650064839455477 LLGGLAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLGGLAVR 8 0 P23396;P23396-2;E9PL09;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 0 11129300.0 5080800.0 4480700.0 1567800.0 False True 4224910.317603961 4456561.579750687 1895619.731311831 1.0 1.0548298649515715 0.4486769159130645 22.01048928687965 -6.884808024800287 1.0525891588831786 1.0367371039038782 0.4015478134166105 0.9773624775194423 0.04118576077710474 0.12345771327001738 0.24725594103860776 0.02999794734742422 0.07351719174907625 1.3037429566329259e-07 6.884808024800287 -0.6351892904872677 down LLGGLAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLGGLAVR 8 0 P23396;P23396-2;E9PL09;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 0 35707800.0 9601800.0 14263000.0 11843000.0 False True 12429719.379774159 13469251.511815334 9687695.519441742 1.0 1.0836327917211646 0.7793977662283927 23.567290389887678 -6.8334075401082925 1.312492324398071 1.0445950616613362 0.7706192261214909 0.9125358494700588 0.03795293272896303 0.1766475323291535 0.593895254822454 0.022694901930676945 0.05223237542712992 1.467548489982677e-07 6.8334075401082925 -0.2739758355398453 LLGGQLGLEDFIFAHVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLGGQLGLEDFIFAHVK 17 0 Q8TF65 Q8TF65 GIPC2 PDZ domain-containing protein GIPC2 0 6869300.0 2686300.0 2080700.0 2102300.0 False True 3477468.3048894256 1964907.215917705 1719702.9714196022 1.0 0.565039575818703 0.4945272884303928 21.729605934821457 -13.999999999999998 0.25605755068263114 4.119743683300935 0.46776545430606536 0.999554397672961 0.004718422129301719 14.246486819675134 0.16012229246359333 22.943536058878884 0.03148090931222794 1.0000000000000041e-14 13.999999999999998 -3.6519782289948695 LLGGVTIAQGGVLPNIQAVLLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLGGVTIAQGGVLPNIQAVLLPK 23 0 Q8IUE6;P16104;Q96QV6 Q8IUE6;P16104 HIST2H2AB;H2AFX;HIST1H2AA Histone H2A type 2-B;Histone H2AX;Histone H2A type 1-A 0 802843000.0 568780000.0 84413000.0 149650000.0 False True 550724390.234431 118119551.10797954 110452175.59623249 1.0 0.214480333906582 0.20055798790610213 29.036755262432543 LLGGVTIAQGGVLPNIQAVLLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLGGVTIAQGGVLPNIQAVLLPK 23 0 Q8IUE6;P16104;Q96QV6 Q8IUE6;P16104 HIST2H2AB;H2AFX;HIST1H2AA Histone H2A type 2-B;Histone H2AX;Histone H2A type 1-A 0 6122000000.0 2357600000.0 1942500000.0 1821900000.0 False True 3576651563.6471896 1595845698.1782255 1461800666.4328618 1.0 0.44618427872546434 0.4087064787888457 31.735962432234608 -13.999999999999998 0.38258398664310744 9.352578916230819 0.4055617003448569 0.9998116511290223 0.00371012320518222 24.364779467982697 0.20197258247440478 167.79251502082218 0.010079956981481276 1.0000000000000041e-14 13.999999999999998 -8.947017215885962 LLGGVTIAQGGVLPNIQAVLLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLGGVTIAQGGVLPNIQAVLLPK 23 0 Q8IUE6;P16104;Q96QV6 Q8IUE6;P16104 HIST2H2AB;H2AFX;HIST1H2AA Histone H2A type 2-B;Histone H2AX;Histone H2A type 1-A 0 844780000.0 568780000.0 137960000.0 138040000.0 False True 472965771.22633845 137216782.09708402 166903525.77515325 1.0 0.2901198996732868 0.3528871134636111 28.81716053786682 -10.10806114075182 5.605588050252121 1.000006787436307 0.3215035066072777 0.9936224602783312 0.02562460772750197 2.1736765001414036e-06 3.458702120335517e-07 0.024811167627351992 0.008270306581748038 7.797203323768671e-11 10.10806114075182 -0.6785032808290292 LLGGVTIAQGGVLPNIQAVLLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLGGVTIAQGGVLPNIQAVLLPK 23 0 Q8IUE6;P16104;Q96QV6 Q8IUE6;P16104 HIST2H2AB;H2AFX;HIST1H2AA Histone H2A type 2-B;Histone H2AX;Histone H2A type 1-A 0 5802700000.0 2357600000.0 1901800000.0 1543300000.0 False True 3051959675.243758 1795963158.1834426 1262435235.5952413 1.0 0.588462283021482 0.4136474167190336 31.507088754327057 -13.999999999999996 0.1170437883357474 2.9665455212879164 0.12318555978130569 0.9997075623784999 0.004203274527753056 11.976050350528274 0.10489625866539114 5.500850205810836 0.2577379521092769 1.0000000000000082e-14 13.999999999999996 -2.8433599615066107 LLGGVTIAQGGVLPNIQAVLLPK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLGGVTIAQGGVLPNIQAVLLPKK 24 1 Q8IUE6;P16104;Q96QV6 Q8IUE6;P16104 HIST2H2AB;H2AFX;HIST1H2AA Histone H2A type 2-B;Histone H2AX;Histone H2A type 1-A 1 210641700.0 110810000.0 94931100.0 4900600.0 True False 145272983.08556646 80767749.91852961 4393532.921874574 1.0 0.5559722682293723 0.030243289760813703 27.114191184075107 -7.766785792904256 0.5763183348961245 1.0086148972861189 1.914308419794933e-21 0.9913997248733493 0.03675839106475643 0.11522176064062564 0.12991866035426644 0.03769860696948479 0.07718757859837014 1.710858954093069e-08 7.766785792904256 -1.0086148972861189 down LLGGVTIAQGGVLPNIQAVLLPK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLGGVTIAQGGVLPNIQAVLLPKK 24 1 Q8IUE6;P16104;Q96QV6 Q8IUE6;P16104 HIST2H2AB;H2AFX;HIST1H2AA Histone H2A type 2-B;Histone H2AX;Histone H2A type 1-A 1 1304681900.0 75550200.0 1214353700.0 14778000.0 True False 114615176.85945804 997642794.4462363 11857121.82257249 1.0 8.704281769503815 0.10345158597200245 26.772222851449843 -6.670658650523509 1.9352465239813927 5.915310198784081 0.13866285094855704 0.2815623357730692 3.272222212436819 0.45982513244405615 3.320793504175917 1.3609753043075805 3.632788762168539 2.1347221160894185e-07 6.670658650523509 -5.776647347835524 LLGGVTIAQGGVLPNIQAVLLPK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLGGVTIAQGGVLPNIQAVLLPKK 24 1 Q8IUE6;P16104;Q96QV6 Q8IUE6;P16104 HIST2H2AB;H2AFX;HIST1H2AA Histone H2A type 2-B;Histone H2AX;Histone H2A type 1-A 1 1338557000.0 75550200.0 1019871600.0 243135200.0 True False 97801223.21708572 963114848.9208121 198887088.37782404 1.0 9.84767692304852 2.0335848758901696 26.543349173542293 -6.616233462249486 2.1300905034247872 6.886162449716595 2.0625280927127356 0.07028553976334917 3.8084838956839144 0.5957492551698382 5.13081109757762 1.471626993200956 4.225896251848052 2.4197279319012857e-07 6.616233462249486 -4.82363435700386 LLGGVTIAQGGVLPNIQAVLLPKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLGGVTIAQGGVLPNIQAVLLPKK 24 1 Q8IUE6;P16104;Q96QV6 Q8IUE6;P16104 HIST2H2AB;H2AFX;HIST1H2AA Histone H2A type 2-B;Histone H2AX;Histone H2A type 1-A 1 879556700.0 9586700.0 521390000.0 348580000.0 True False 9282375.455994269 729583746.0129302 257276440.82415444 1.0 78.59881874760708 27.716659603336055 23.146062622525672 -9.175849216574926 10.629751119866741 1.000000012882727 53.15773917590315 0.5835108193961807 20.772554485765614 0.0 0.0 20.112939695092205 6.70431313179535 6.670383191610691e-10 9.175849216574926 52.15773916302042 LLGGVTIAQGGVLPNIQAVLLPKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLGGVTIAQGGVLPNIQAVLLPKK 24 1 Q8IUE6;P16104;Q96QV6 Q8IUE6;P16104 HIST2H2AB;H2AFX;HIST1H2AA Histone H2A type 2-B;Histone H2AX;Histone H2A type 1-A 1 89450600.0 9586700.0 1613900.0 78250000.0 True False 7971765.812819612 1605205.6003659314 94611713.21287848 1.0 0.201361359334535 11.868350806383553 22.92646789795995 -6.890503334989923 1.0194220410207697 0.38066047339555986 12.881690533143317 0.9812177316495672 0.7293206805591845 0.11873484832476473 0.21948044466869027 0.5447641911461228 1.3605620207570566 1.2867573718556674e-07 6.890503334989923 12.501030059747757 up LLGHGQPLNWISLEQNGIMVELPQLTIHQMPCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLGHGQPLNWISLEQNGIMVELPQLTIHQMPCK 33 0 Q9BTY2 Q9BTY2 FUCA2 Plasma alpha-L-fucosidase 0 43365000.0 10178000.0 17778000.0 15409000.0 False True 15440770.111469777 14605376.999852005 12363404.395995392 1.0 0.9458969270582416 0.8006986896859215 23.880241373313083 -6.953924649884102 0.5139549177686389 1.0025877047147569 0.7375947339211579 0.9994743680140717 0.0019292654212622398 0.08194702737138373 0.029728615447478117 0.002207262250299417 0.011987012899526151 1.1119246295296797e-07 6.953924649884102 -0.26499297079359896 LLGHLVKEK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLGHLVKEK 9 1 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 1 2150710.0 644200.0 882080.0 624430.0 True False 844552.4384416741 750477.1023209097 559819.9735555123 1.0 0.8886092421989243 0.6628599339414188 19.687827477488412 -6.9597851486061595 0.43845116402445355 1.0082034280266226 0.5344867044949215 0.9997621464374545 0.0021630196372493396 0.07977795913456756 0.02141556409975014 0.0029707451158297498 0.018710324247719616 1.0970207730362173e-07 6.9597851486061595 -0.473716723531701 LLGHLVKEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLGHLVKEK 9 1 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 1 2736380.0 703340.0 614640.0 1418400.0 True False 681012.8566888509 860068.9573052571 1046878.4889121016 1.0 1.2629261677774983 1.5372374818327572 19.377322509247083 -6.9705914464425565 0.243645136628278 0.905849471204792 1.9022842745585744 0.9999866347629601 0.0008018631582890658 0.07611125499221028 0.008340483632293505 0.0063913209598594626 0.026572206887181902 1.0700610436940674e-07 6.9705914464425565 0.9964348033537824 LLGHLVKEK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLGHLVKEK 9 1 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 1 2335470.0 703340.0 895870.0 736260.0 True False 584858.3732450732 891043.7704937278 890208.5619183896 1.0 1.5235205842224535 1.5220925315287663 19.15772778468136 -10.169006717033058 5.128727770662986 0.9999713983438425 1.5228065578760666 0.9999944036117332 0.0005830000724936742 1.9068067593935498e-07 3.089590034222158e-08 0.0005645182065764953 0.0001881624640701586 6.77631026922114e-11 10.169006717033058 0.522835159532224 LLGIHTQTRPVIIQALWQYIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLGIHTQTRPVIIQALWQYIK 21 1 Q96GM5;Q96GM5-2;F8VRQ4;F8VUB0 Q96GM5 SMARCD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 0 53968000.0 16039000.0 22280000.0 15649000.0 False True 24332335.60796457 18303959.92556545 12555968.290799629 1.0 0.7522483751857391 0.516019854941083 24.53637147229322 -6.971703778794941 0.21360702218422603 1.1181274004936284 0.1435192680091097 0.9999927967905822 0.00053031050742286 0.07575360397737041 0.007016835467550199 0.006875516028590736 0.024278785955901237 1.0673238674397727e-07 6.971703778794941 -0.9746081324845186 LLGIHTQTRPVIIQALWQYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLGIHTQTRPVIIQALWQYIK 21 1 Q96GM5;Q96GM5-2;F8VRQ4;F8VUB0 Q96GM5 SMARCD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 0 53438000.0 16039000.0 18253000.0 19146000.0 False True 20762801.675956327 17237204.50432348 15661624.454549663 1.0 0.8301964625652833 0.7543117108654025 24.307497794385668 -13.999999999914563 0.10895465849957442 1.8208662241465783 0.6129854156773801 0.9997483717866023 0.0016293463000841605 12.018888829309864 0.09999116940112997 2.1746101968859235 0.12556194448501407 1.0000000001967269e-14 13.999999999914563 -1.207880808469198 LLGK(ub)VTIAQGGVLPNIQAVLLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLGKVTIAQGGVLPNIQAVLLPK 23 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q16777 A0A0U1RR32;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 2-C 1 141598000.0 22497000.0 24559000.0 94542000.0 True False 34129593.75100563 20176254.56965719 75855732.26076934 1.0 0.5911659751022585 2.2225794076008962 25.024519906163764 -6.840331518278246 1.2809085815272645 0.7825275767520568 2.2765754415042982 0.9250220440458496 0.18978243527265332 0.16840474279144949 0.536592891596455 0.11617516056536141 0.2676610842096138 1.4443368166995538e-07 6.840331518278246 1.4940478647522415 up LLGK(ub)VTIAQGGVLPNIQAVLLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLGKVTIAQGGVLPNIQAVLLPK 23 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q16777 A0A0U1RR32;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 2-C 1 11201400.0 5710100.0 2931700.0 2559600.0 True False 4748201.150320892 2915906.3502031146 3094800.5257467567 1.0 0.6141075868291831 0.6517837866952213 22.17894962318003 -9.821092772388688 6.499285772595883 1.0000000079923754 0.6329456871995498 0.9921599911077721 0.015381244186703618 1.7851081122755984e-09 3.0730817927421214e-10 0.014892826088506984 0.004964275214888802 1.50975761085135e-10 9.821092772388688 -0.36705432079282563 LLGLCAWARK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLGLCAWARK 10 1 F6TD35;E9PFL3;H0YN69;Q6PKH6;Q6PKH6-2 F6TD35 DHRS4L2 Dehydrogenase/reductase SDR family member 4-like 2 1 64485000.0 18860000.0 17806000.0 27819000.0 True False 28611998.850689672 14628380.181087026 22320562.45649914 1.0 0.5112673272994493 0.7801119583772498 24.77011695289834 -10.10850046015321 5.336734089912485 1.0000061899602812 0.6456896428381199 0.6984149389230471 0.1097553610387087 8.083376219727718e-06 1.3504481977978568e-06 0.10627202667473047 0.03542339045487496 7.789319892421396e-11 10.10850046015321 -0.3543165471221613 LLGLCAWARK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLGLCAWARK 10 1 F6TD35;E9PFL3;H0YN69;Q6PKH6;Q6PKH6-2 F6TD35 DHRS4L2 Dehydrogenase/reductase SDR family member 4-like 2 1 46713000.0 18860000.0 16481000.0 11372000.0 True False 24414641.7861797 15563817.862036632 9302412.686573632 1.0 0.6374788538100437 0.38101778301901656 24.54124327499079 -8.000181168329691 0.18365551256035034 1.2808415436619294 2.636886969630758e-10 0.9998875315427096 0.0026929710992757146 0.10428382811204488 0.031661272542009115 0.08290362590880068 0.1060405264276697 9.995829315019869e-09 8.000181168329691 -1.2808415433982407 down LLGLGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLGLGQK 7 0 P49321;P49321-2;P49321-3;Q5T624;E9PI86;E9PPQ8 P49321 NASP Nuclear autoantigenic sperm protein 0 5362360.0 602560.0 1826100.0 2933700.0 False True 789961.9951993405 1553652.9980820478 2630148.8660375117 1.0 1.9667439794872614 3.329462533667604 19.591423721832463 -6.966269677467798 0.33554814290035806 0.8443594949648875 4.4968303276751245 0.9999369758836695 0.007586035055554002 0.077532717182834 0.013355056554603189 0.01951009933138957 0.11834272603693578 1.0807626375850862e-07 6.966269677467798 3.652470832710237 LLGLGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLGLGQK 7 0 P49321;P49321-2;P49321-3;Q5T624;E9PI86;E9PPQ8 P49321 NASP Nuclear autoantigenic sperm protein 0 8613460.0 602560.0 4485800.0 3525100.0 False True 825342.7155717247 4287602.5234430935 2692543.981713396 1.0 5.1949359248576155 3.262334459265493 19.654633783355354 -9.194358247516224 10.84084804714989 1.000000000010218 4.228635192140778 0.7881929290537375 0.788981244476089 0.0 0.0 0.7639278050814067 0.2546426016938022 6.392073387604611e-10 9.194358247516224 3.2286351921305596 LLGLGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLGLGQK 7 0 P49321;P49321-2;P49321-3;Q5T624;E9PI86;E9PPQ8 P49321 NASP Nuclear autoantigenic sperm protein 0 3611100.0 1005300.0 1121300.0 1484500.0 False True 1301380.667425582 1058898.6692980821 1214336.2322562903 1.0 0.8136732747020264 0.9331137788134776 20.311611596466598 -10.6978306161707 5.1971429135118505 1.0034043832053887 0.8733935267577518 0.5996993581465939 0.048761381615642425 0.001971961488288948 0.00011465253132420138 0.04840377627449263 0.015737668244620556 2.0052539653850848e-11 10.6978306161707 -0.13001085644763688 LLGLLFPLLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLGLLFPLLAR 11 0 Q8TEX9;Q8TEX9-2;H0YN07;H0YMR4 Q8TEX9 IPO4 Importin-4 0 1041300000.0 348530000.0 393020000.0 299750000.0 False True 528745490.9560386 322882510.3207243 240504281.11490804 1.0 0.6106577093204368 0.45485831128327153 28.9779982143469 -13.99999999999798 0.1263015532891073 2.8503857624333175 0.22606594234413477 0.9996626661923866 0.004210729636218161 11.944006379785517 0.11013513127897642 5.506300534087393 0.20323465891227124 1.0000000000046506e-14 13.99999999999798 -2.6243198200891826 LLGLLFPLLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLGLLFPLLAR 11 0 Q8TEX9;Q8TEX9-2;H0YN07;H0YMR4 Q8TEX9 IPO4 Importin-4 0 931420000.0 348530000.0 302320000.0 280570000.0 False True 451178955.55340534 285495626.23936176 229509138.89130852 1.0 0.6327769119665159 0.5086875973853835 28.74912453643935 -13.999999999999998 0.1515054882572959 2.7799195758082687 0.37449982006148724 0.9995612920602464 0.004369271042135153 11.963692235087697 0.12266110048934953 6.266311054392012 0.12112909922931649 1.0000000000000041e-14 13.999999999999998 -2.4054197557467814 LLGLTGSTK(ub)QVAQASHSYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLGLTGSTKQVAQASHSYR 19 1 O43819 O43819 SCO2 Protein SCO2 homolog, mitochondrial 1 15794300.0 3998400.0 7962100.0 3833800.0 True False 5241941.120560678 6774185.71602272 3437115.152406389 1.0 1.29230480850921 0.6556951086163202 22.3216697181923 -6.781853588442788 1.5285702134982968 1.1651123859871964 0.6503492330801885 0.7739130548392599 0.12371369385635815 0.24770885890585984 1.143293031371882 0.06373680199259318 0.15016571584834487 1.652518809850374e-07 6.781853588442788 -0.5147631529070078 LLGLTGSTK(ub)QVAQASHSYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLGLTGSTKQVAQASHSYR 19 1 O43819 O43819 SCO2 Protein SCO2 homolog, mitochondrial 1 26960700.0 5996200.0 8933500.0 12031000.0 True False 5805853.913153931 12500693.137587063 8879720.177736524 1.0 2.1531187874474567 1.5294425782258048 22.469076840665274 -10.300679056476998 5.857995135804586 0.9999326523834083 1.841280682836634 0.7081198532427726 0.2546147462177334 0.00022397079852967143 2.6737119042122017e-05 0.246549197720785 0.0821765559833408 5.004041969574337e-11 10.300679056476998 0.8413480304532256 LLGLTGSTK(ub)QVAQASHSYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLGLTGSTKQVAQASHSYR 19 1 O43819 O43819 SCO2 Protein SCO2 homolog, mitochondrial 1 48843000.0 6225000.0 10726000.0 31892000.0 True False 9443780.108459359 8811861.497379499 25588532.221239846 1.0 0.9330862637818289 2.7095645946180666 23.17093301917869 -6.898147545666551 0.9729163820038711 0.9223396973073484 2.8891693716674407 0.9856215863522187 0.09858068865778474 0.11278130774279992 0.18521498946264028 0.07625211851664905 0.19661138098906 1.2643067434115328e-07 6.898147545666551 1.9668296743600924 up LLGLTGSTK(ub)QVAQASHSYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLGLTGSTKQVAQASHSYR 19 1 O43819 O43819 SCO2 Protein SCO2 homolog, mitochondrial 1 21713000.0 3998400.0 11010000.0 6704600.0 True False 5476716.53269713 10523541.794798803 5121111.565571369 1.0 1.921505656166625 0.9350696781542871 22.38487977971519 -6.661507858926517 1.9677913084446956 1.592428662943766 0.9391906877687975 0.24196988477846704 0.3922159240927599 0.4808523750259179 3.5809944886408767 0.16095402135054585 0.43479808938348896 2.1801789446442705e-07 6.661507858926517 -0.6532379751749685 LLGLTGSTK(ub)QVAQASHSYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLGLTGSTKQVAQASHSYR 19 1 O43819 O43819 SCO2 Protein SCO2 homolog, mitochondrial 1 17977900.0 5996200.0 8049600.0 3932100.0 True False 4986105.976699899 8006235.207079494 4754283.9300237615 1.0 1.605708993048418 0.9535063940158025 22.24948211609955 -6.66283160187814 1.9633776871195316 1.3889903030323254 0.956241254827554 0.24748630765727042 0.2577265697639543 0.47776686650949346 3.5435219974477277 0.1059575271041883 0.28570327610693896 2.173543809284433e-07 6.66283160187814 -0.43274904820477145 LLGLTGSTK(ub)QVAQASHSYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLGLTGSTKQVAQASHSYR 19 1 O43819 O43819 SCO2 Protein SCO2 homolog, mitochondrial 1 22212400.0 6225000.0 8053500.0 7933900.0 True False 8058385.21309485 7605315.645404543 6490011.608688578 1.0 0.9437766307133009 0.8053737116143728 22.94205934127114 -6.955792038729636 0.4911611688059699 1.0029972122000297 0.7402726576937536 0.9995808970787937 0.0016742476663140979 0.08123996837531079 0.026957086473442325 0.00199771347276129 0.011415081733408468 1.1071538160323987e-07 6.955792038729636 -0.2627245545062761 LLGPK(ub)NSEGLHSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLGPKNSEGLHSAR 14 1 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 1 3799570.0 958970.0 1253100.0 1587500.0 True False 1257218.9566786913 1066142.3645455434 1423240.7283752766 1.0 0.8480164563872532 1.1320547791732156 20.26180450007344 -6.761385644568702 1.6075779937305308 0.9118702335585145 1.1331523884288153 0.6964760466558007 0.06393723130509318 0.28059560010472545 1.4295493430601478 0.03137818204883736 0.07529415113950302 1.7322650988160837e-07 6.761385644568702 0.22128215487030078 LLGPK(ub)NSEGLHSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLGPKNSEGLHSAR 14 1 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 1 4604130.0 804630.0 1064100.0 2735400.0 True False 779087.4610821938 1489000.6792081944 2018916.679759001 1.0 1.9112111971868904 2.5913864368380652 19.57142577010086 -7.405089055985242 0.14144613377574392 1.4753681483170438e-15 4.227068263744199 0.9999922602080432 0.0018137721832568996 0.12523728160397538 0.010668283447469137 0.10875895821773152 0.19168111119121028 3.934693827507929e-08 7.405089055985242 4.227068263744197 LLGPK(ub)NSEGLHSAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLGPKNSEGLHSAR 14 1 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 1 15948900.0 1488500.0 2706400.0 11754000.0 True False 2258163.323926382 2223421.7748002848 9430816.748038791 1.0 0.9846151300227077 4.176321813446583 21.106718403573918 -6.905815046634172 0.9237713735602379 0.8876298512351709 4.553893503818055 0.9892439575912387 0.1556678046230221 0.10725058510073869 0.15426322717201071 0.12486692380607385 0.33546562880974673 1.242181203744997e-07 6.905815046634172 3.6662636525828844 up LLGPK(ub)NSEGLHSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLGPKNSEGLHSAR 14 1 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 1 5498730.0 804630.0 2535900.0 2158200.0 True False 669085.4961529039 2522238.6033632625 2609469.641610663 1.0 3.7696805832223026 3.900054113584207 19.351831045535135 -10.277478234888672 0.635807935180997 3.5482077811584633e-19 3.8821110520648254 0.9997968106758411 0.019064309817579676 1.590013007902499 0.31122618987514084 2.852073949051523 0.021655830570298358 5.278636605449317e-11 10.277478234888672 3.8821110520648254 LLGPVLVK(ub)QELGEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLGPVLVKQELGEAR 15 1 O15212;A2AB88 O15212 PFDN6 Prefoldin subunit 6 1 7798200.0 2416000.0 2154100.0 3228100.0 True False 2339305.4024515375 3014243.3634830997 2382563.7690758314 1.0 1.2885206695646678 1.0184919705562856 21.15764879092907 -10.60203563722165 2.9889153038217744 0.9900943156478081 1.1535063199433886 0.30113665967965264 0.11023875626201267 20755208.647427406 23269688.563655384 1618964.7028537085 0.04692671932646195 2.500140197436285e-11 10.60203563722165 0.16341200429558045 LLGPVLVK(ub)QELGEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLGPVLVKQELGEAR 15 1 O15212;A2AB88 O15212 PFDN6 Prefoldin subunit 6 1 6770300.0 2416000.0 2720800.0 1633500.0 True False 2009011.0469475612 2706142.5103634847 1975057.2975493572 1.0 1.3470023046787756 0.9830992719279505 20.938054066363346 -6.656970439010012 1.9839751060141955 1.2239183854690994 0.9846325277906529 0.22271905697862138 0.14785377001176012 0.49163389642903704 3.716879091193292 0.060281730202627754 0.16381989191407806 2.2030764140801398e-07 6.656970439010012 -0.23928585767844646 LLGQFSEK(ub)ELAAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLGQFSEKELAAEK 14 1 P53004 P53004 BLVRA Biliverdin reductase A 1 24485100.0 7703000.0 12292000.0 4490100.0 True False 10098707.595958108 10458081.51384072 4025507.524080522 1.0 1.0355861296574669 0.39861610862876007 23.267667336970135 -6.89367718782276 1.000398773240281 1.0312696003339101 0.3397199526944031 0.9831486756227149 0.03793698685211991 0.1162094423518628 0.20483622863650294 0.028746467884818567 0.07268056954874774 1.277387941680877e-07 6.89367718782276 -0.6915496476395071 down LLGQFSEK(ub)ELAAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLGQFSEKELAAEK 14 1 P53004 P53004 BLVRA Biliverdin reductase A 1 24587800.0 7703000.0 11435000.0 5449800.0 True False 10551007.265747799 10929763.889511747 4162669.4821541687 1.0 1.0358976744328026 0.3945281599480674 23.330877398493026 -6.8936516464853685 1.0005540370938342 1.0315058228879743 0.33525535073237894 0.9831337095952238 0.038214136234572704 0.1162294476114572 0.20495201432379928 0.02895310645895037 0.07319536689726512 1.277463068483469e-07 6.8936516464853685 -0.6962504721555953 down LLGQFSEK(ub)ELAAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLGQFSEKELAAEK 14 1 P53004 P53004 BLVRA Biliverdin reductase A 1 26515400.0 11273000.0 10445000.0 4797400.0 True False 9373998.978576113 10388730.711829832 5800514.159328607 1.0 1.1082496099661252 0.6187875817551765 23.160233206939996 -6.848697256818035 1.2413063955886123 1.0577095101693952 0.5997013001237428 0.9383949183152852 0.05210399355864928 0.15889659489078903 0.47179200604756444 0.03285566328237235 0.07597191934534492 1.4167810624600316e-07 6.848697256818035 -0.4580082100456524 LLGQFTLIGIPPAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLGQFTLIGIPPAPR 15 0 P38646;H0Y8S0 P38646 HSPA9 Stress-70 protein, mitochondrial 0 41061400.0 12285130.0 17265110.0 11511160.0 False True 16105924.399368135 14689222.886871675 10320095.5860437 1.0 0.9120384848849756 0.6407639406558109 23.9410881307759 -6.950827955522957 0.5496773777449127 1.0037588368819053 0.5363065239008125 0.9992646748780846 0.004145890514575678 0.08315494418831243 0.03459934022829752 0.004501718193112207 0.022503158691704897 1.1198814333299816e-07 6.950827955522957 -0.4674523129810928 LLGQFTLIGIPPAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLGQFTLIGIPPAPR 15 0 P38646;H0Y8S0 P38646 HSPA9 Stress-70 protein, mitochondrial 0 59843900.0 27240900.0 15769000.0 16834000.0 False True 26376152.540414765 22065643.93424865 12424670.39082511 1.0 0.8365755354363622 0.4710569660145638 24.652730799851717 -6.957800590873915 0.4653971424541868 1.0100989813375523 0.2826646710855577 0.9996797229346446 0.003957427765406144 0.08049636809119669 0.024106764107019625 0.005011273534682506 0.030179373601240848 1.1020452045882178e-07 6.957800590873915 -0.7274343102519946 down LLGQFTLIGIPPAPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLGQFTLIGIPPAPR 15 0 P38646;H0Y8S0 P38646 HSPA9 Stress-70 protein, mitochondrial 0 76151900.0 19748900.0 26954000.0 29449000.0 False True 29960525.137984376 22143848.107436784 23628392.24204477 1.0 0.739100800318166 0.788650804123869 24.836559575302132 -10.572445571816775 6.3799680058199515 1.0004419334991184 0.7638758022210186 0.9680290114194611 0.02022870434615614 0.00012739110716335504 8.537128036405232e-06 0.01962218986210025 0.00652878625400135 2.6764209960436097e-11 10.572445571816775 -0.23656613127809978 LLGQFTLIGIPPAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLGQFTLIGIPPAPR 15 0 P38646;H0Y8S0 P38646 HSPA9 Stress-70 protein, mitochondrial 0 102662200.0 12285130.0 32390070.0 57987000.0 False True 16827274.554155022 30958969.607761946 44291664.87975222 1.0 1.8398089071481571 2.632135390505983 24.00429819229879 -6.971829156762025 0.20994686923675074 0.5848897761613707 3.909172030848168 0.9999933530739356 0.001718105315295345 0.07571352086556338 0.006864109032861842 0.023736544386337634 0.08211437786197198 1.0670157825162124e-07 6.971829156762025 3.324282254686797 LLGQFTLIGIPPAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLGQFTLIGIPPAPR 15 0 P38646;H0Y8S0 P38646 HSPA9 Stress-70 protein, mitochondrial 0 52604900.0 27240900.0 11259000.0 14105000.0 False True 22652015.3264875 11198345.532263469 17054290.28584857 1.0 0.49436420428203565 0.7528818094126315 24.433136075285994 -10.288089270714318 4.9490757102764515 1.0001128024698989 0.6236230068471603 0.7386448553934988 0.10553937035010678 0.0001313992247849214 1.8901325012428006e-05 0.10221851091248078 0.0340626853111609 5.151227484578544e-11 10.288089270714318 -0.37648979562273854 LLGQFTLIGIPPAPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLGQFTLIGIPPAPR 15 0 P38646;H0Y8S0 P38646 HSPA9 Stress-70 protein, mitochondrial 0 76325600.0 19748900.0 35121900.0 21454800.0 False True 25565340.35901826 33167335.390368626 17550246.544838175 1.0 1.2973555182365777 0.686485933626433 24.607685897394582 -6.774359509473614 1.5579386812601088 1.1696051162197574 0.6824834186495616 0.7468910253691531 0.12548080272062387 0.259439902836437 1.2433215178625696 0.06346616316862541 0.1504691798407033 1.6812817179108197e-07 6.774359509473614 -0.48712169757019574 LLGSLYALGIPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLGSLYALGIPK 12 0 Q969Z0;Q969Z0-2;C9IZN7;C9J7P5 Q969Z0 TBRG4 Protein TBRG4 0 14356900.0 3799100.0 4502700.0 6055100.0 False True 4980656.890536729 3830914.71138713 5428576.33662057 1.0 0.7691585257892157 1.0899318013523256 22.24790459881074 -6.713574139890994 1.7822737877764299 0.8586061531050035 1.0892666426271045 0.48213325811753704 0.09722282099065381 0.36794336610820355 2.2804114303603593 0.04337307241661369 0.10972092140884615 1.933863693976896e-07 6.713574139890994 0.23066048952210094 LLGSLYALGIPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLGSLYALGIPK 12 0 Q969Z0;Q969Z0-2;C9IZN7;C9J7P5 Q969Z0 TBRG4 Protein TBRG4 0 13551400.0 4305000.0 2624000.0 6622400.0 False True 4168340.1314378576 3671776.8839792293 4887794.772258537 1.0 0.8808726659051836 1.1725997922757099 21.991041573888197 -6.795865528694634 1.4730396812786366 0.9339233934790748 1.1762136946671171 0.8197023018396816 0.050852771546763806 0.2267193542814836 0.9716424374904574 0.027166061271977144 0.06333544664125634 1.6000533790475474e-07 6.795865528694634 0.2422903011880423 LLGSLYALGIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLGSLYALGIPK 12 0 Q969Z0;Q969Z0-2;C9IZN7;C9J7P5 Q969Z0 TBRG4 Protein TBRG4 0 18242400.0 3799100.0 4394300.0 10049000.0 False True 5203729.93681714 4200145.29599313 7675633.165651446 1.0 0.8071412903802896 1.4750252720352057 22.311114660333633 -6.829493107080071 1.3303912378011717 0.8969162016064453 1.4927843467822275 0.9048142636032537 0.08658865620667085 0.18144026119094575 0.6282770290518316 0.05110780202548782 0.11760262984128896 1.48083575821708e-07 6.829493107080071 0.5958681451757822 LLGSLYALGIPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLGSLYALGIPK 12 0 Q969Z0;Q969Z0-2;C9IZN7;C9J7P5 Q969Z0 TBRG4 Protein TBRG4 0 8405800.0 4305000.0 2046500.0 2054300.0 False True 3579798.2438366087 2035475.098301556 2483844.6319899852 1.0 0.5686005075302955 0.6938504526802473 21.771446849322473 -10.508349855902086 9.254509523855086 1.0000103939342517 0.631225480105274 0.9203733271816851 0.051133075988160435 1.09660655321793e-05 5.825293820756583e-07 0.049510781344958656 0.016503129311875312 3.1020596458725024e-11 10.508349855902086 -0.3687849138289777 LLGYVATLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLGYVATLK 9 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 18050300.0 8311600.0 5702100.0 4036600.0 False True 10896588.089648902 4851368.906611717 3618931.353801351 1.0 0.4452190783663946 0.3321160095277086 23.377373137131265 -13.999999999999998 0.2235467123816211 4.400792127197333 0.2736353066701648 0.9995016929572379 0.006515139684309439 13.098539309529716 0.14975401849496453 19.70169085405676 0.06116171717742421 1.0000000000000041e-14 13.999999999999998 -4.127156820527168 LLGYVATLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLGYVATLK 9 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 12250600.0 5889500.0 1567300.0 4793800.0 False True 5702541.046249309 2193131.063361525 3538159.9690826484 1.0 0.3845883871022721 0.6204532225874598 22.44317349525566 -10.241157973827365 5.538856440041708 1.0000311643360937 0.5025208048448626 0.8557304149298783 0.09629141586744659 3.7059114180148e-05 5.0771103988523895e-06 0.09323958828824229 0.03107792083643471 5.739076663659627e-11 10.241157973827365 -0.4975103594912311 LLGYVATLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLGYVATLK 9 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 17335900.0 8311600.0 4062800.0 4961500.0 False True 11384623.132544396 3883292.062117038 3789695.8852999997 1.0 0.34109974628990153 0.33287846608349037 23.440583198654156 LLGYVATLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLGYVATLK 9 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 9914600.0 5889500.0 2956600.0 1068500.0 False True 4897380.199088436 2940672.2089608493 1291918.409814194 1.0 0.6004582224406848 0.26379785871120703 22.223578770689937 -7.744411720398882 0.2821713673235787 1.1197516479464575 1.9118431691108794e-11 0.99958233830423 0.006149800150306273 0.12363342736617115 0.040838452302139616 0.03987097963243901 0.08084153496415779 1.8013092516917708e-08 7.744411720398882 -1.119751647927339 down LLHDLQIGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLHDLQIGEK 10 0 P49756;P49756-2;P49756-3;E9PQU5 P49756 RBM25 RNA-binding protein 25 0 3228630.0 769530.0 1038900.0 1420200.0 False True 1008861.2821391209 883900.1696004813 1273251.327520359 1.0 0.8761364770846587 1.2620677887654124 19.944296387645494 -6.820334696352219 1.370299121715835 0.9332572629157188 1.270561313074666 0.8851581451727254 0.054522263734078306 0.19306190438599521 0.7122136174762614 0.03126485327635635 0.07205856357320685 1.5123952463421774e-07 6.820334696352219 0.33730405015894727 LLHDLQIGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLHDLQIGEK 10 0 P49756;P49756-2;P49756-3;E9PQU5 P49756 RBM25 RNA-binding protein 25 0 3843230.0 769530.0 1734300.0 1339400.0 False True 1054046.0367663128 1657672.8914368348 1023061.3058088918 1.0 1.5726759872105558 0.9706040060143118 20.007506449168385 -6.657554684128272 1.9819684620425206 1.3693796370173599 0.9731464006811777 0.22505199864116432 0.24397889324684432 0.4902999253804586 3.6999508695961825 0.09955330295923222 0.2703269647815707 2.2001146650688354e-07 6.657554684128272 -0.3962332363361821 LLHDQVGVIQFGPYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLHDQVGVIQFGPYK 15 0 P53621;P53621-2;A0A3B3IS84;A0A3B3ISC6 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 18104400.0 5393400.0 6026100.0 6684900.0 False True 7070799.6297598975 5127029.369553818 5993210.674088758 1.0 0.7250989475044588 0.847600128401923 22.753441946544946 -10.02521501519872 4.478006681394977 1.0000087396241983 0.7863495379436236 0.8022034639887701 0.05001089775638012 14796152.763152203 11041714.36245371 1177.8014933130755 0.01712006127297008 9.435935961222082e-11 10.02521501519872 -0.21365920168057473 LLHDQVGVIQFGPYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLHDQVGVIQFGPYK 15 0 P53621;P53621-2;A0A3B3IS84;A0A3B3ISC6 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 13369600.0 5774400.0 2202600.0 5392600.0 False True 5591094.832746754 3082109.6664072564 3980116.285467712 1.0 0.5512533338471561 0.7118670679946933 22.41469938461386 -10.305981534745515 4.770323746727188 1.0001801663877883 0.6315602009204874 0.875253741789193 0.06557028239225336 0.00012570166157776537 1.8287963858981825e-05 0.06351894535339461 0.021162717642396068 4.9433170444631375e-11 10.305981534745515 -0.3686199654673009 LLHDQVGVIQFGPYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLHDQVGVIQFGPYK 15 0 P53621;P53621-2;A0A3B3IS84;A0A3B3ISC6 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 21682500.0 5393400.0 6833500.0 9455600.0 False True 7387485.731154641 6531573.374637388 7222382.024194823 1.0 0.8841402355732907 0.9776508932851755 22.816652008067837 -10.09092663885666 4.80147647422762 1.0000029827135404 0.9308955644284849 0.4213507358135091 0.038175566153604235 1.2189514290856155e-06 2.3076713497806002e-07 0.0369649283937374 0.012321110995046304 8.110980571894538e-11 10.09092663885666 -0.06910741828505551 LLHGFNAEGIHFS ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLHGFNAEGIHFS 13 0 Q9UNQ2 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 0 11124400.0 2604200.0 3734700.0 4785500.0 False True 3414131.4191086753 3177497.317746576 4290342.365757412 1.0 0.9306898088229195 1.2566424191361352 21.703087161974317 -6.851116025030175 1.2296339038605224 0.9629739398676799 1.2699600866554974 0.941919209732526 0.03378909140575449 0.15623596924953773 0.45401303222292766 0.021495439350941916 0.049780284159507 1.4089123466310127e-07 6.851116025030175 0.30698614678781755 LLHGFNAEGIHFS ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLHGFNAEGIHFS 13 0 Q9UNQ2 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 0 8720700.0 2604200.0 2892500.0 3224000.0 False True 3567043.115858813 2764699.7857816094 2462557.60036424 1.0 0.7750676669676226 0.6903638448932363 21.766297223497208 -13.999999999999998 0.13549827389973015 2.0709735540395124 0.5796273928026666 0.9996214739833239 0.0025420440382634586 11.932109242950112 0.1149789859219404 3.3884229777467367 0.09872810787235867 1.0000000000000041e-14 13.999999999999998 -1.4913461612368457 LLHGGVAVSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLHGGVAVSSR 11 0 A0A0B4J1S8;Q9UBF8-2;Q9UBF8;A0A0A0MSL0 A0A0B4J1S8 PI4KB Phosphatidylinositol 4-kinase beta 0 2501030.0 699800.0 944790.0 856440.0 False True 917444.5768728395 803831.0147625747 767823.8043525824 1.0 0.8761630239316223 0.8369157371552103 19.807261481345446 -13.99999999999733 0.16081329452980703 1.6109397911437684 0.7986778565983806 0.9995342452626513 0.0014998958138672223 12.01521246820128 0.12675395467750594 2.289485895970566 0.034886355923387055 1.0000000000061476e-14 13.99999999999733 -0.8122619345453878 LLHGGVAVSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLHGGVAVSSR 11 0 A0A0B4J1S8;Q9UBF8-2;Q9UBF8;A0A0A0MSL0 A0A0B4J1S8 PI4KB Phosphatidylinositol 4-kinase beta 0 2110930.0 699800.0 557940.0 853190.0 False True 958534.9713839163 533288.3659391509 651684.0939996174 1.0 0.5563577562216623 0.6798751359678897 19.870471542868337 -10.371511444365005 8.687616874575717 1.0000013239243624 0.6181164460947811 0.9272469955345434 0.05042575912397314 1.2930495571782444e-06 9.354352118829132e-08 0.048824700082515396 0.016274843775584552 4.2509750464730264e-11 10.371511444365005 -0.38188487782958125 LLHIIIDDNKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLHIIIDDNKR 11 1 Q9BPX3;H0Y9Z8 Q9BPX3 NCAPG Condensin complex subunit 3 0 4272100.0 1315100.0 1425300.0 1531700.0 False True 1273352.8703493439 1994429.7228413103 1130501.819984959 1.0 1.5662820332702743 0.8878150325092574 20.280200842261856 -6.6852551053479035 1.8836273649654915 1.3565930093238792 0.8903055078894946 0.34820755146654414 0.23973326140979567 0.4269190236332125 2.933018795971074 0.10196803379691242 0.26709644982716163 2.0641673040992476e-07 6.6852551053479035 -0.4662875014343846 LLHIIIDDNKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLHIIIDDNKR 11 1 Q9BPX3;H0Y9Z8 Q9BPX3 NCAPG Condensin complex subunit 3 0 6357000.0 1734000.0 2427500.0 2195500.0 False True 2375106.659588041 2320245.0233309786 1676968.117741841 1.0 0.9769014010231533 0.706060130382822 21.179560871737685 -6.923730323224355 0.7965705990066999 1.0052113393147672 0.6584033793276071 0.9951559659333176 0.00928826008989542 0.09602636316545976 0.09460262010567602 0.008165162850158246 0.025403408732137225 1.1919819438970728e-07 6.923730323224355 -0.3468079599871602 LLHINATALLEYPEYSGPLLPASAVAPGPSALDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLHINATALLEYPEYSGPLLPASAVAPGPSALDR 34 0 Q969Z0;Q969Z0-2;H7C4R5 Q969Z0 TBRG4 Protein TBRG4 0 77269000.0 20059000.0 29674000.0 27536000.0 False True 30430969.5093311 24378442.85597976 22093497.530542444 1.0 0.801106348205717 0.7260201658631966 24.85903696204771 -13.999999999999998 0.13512268177799594 1.9468017547996674 0.6274012010061779 0.9996230723284683 0.0022442423442424215 11.93215592164559 0.1147874536578692 2.9880652895822273 0.08790684426823808 1.0000000000000041e-14 13.999999999999998 -1.3194005537934896 LLHIVGYGDFQMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLHIVGYGDFQMK 13 0 Q2NL82;I3L1Q5 Q2NL82 TSR1 Pre-rRNA-processing protein TSR1 homolog 0 15443300.0 2606400.0 6253300.0 6583600.0 False True 3954099.353363609 5137349.7577440925 5282348.574305608 1.0 1.2992465030940448 1.3359170071971271 21.91491769097404 -12.439923879208346 0.32248135882936113 1.5768616074753958e-07 1.3434190438490776 0.9995940566913778 0.0030313899134062705 6.876675853070617 0.17607529073140074 4.558484140264649 0.012090001420673737 3.631416987083873e-13 12.439923879208346 1.3434188861629168 LLHLHFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLHLHFK 7 0 J3QR35;J3QR01;J3QRS1;A8MT69-3;A8MT69-2;A8MT69 J3QR35 STRA13 Centromere protein X 0 28437600.0 10383000.0 8309000.0 9745600.0 False True 13612213.549115045 7069329.58822832 8737218.798396286 1.0 0.5193372527341749 0.6418661275677906 23.698398353879565 -10.134184717540522 7.732478327176447 1.0000000846698458 0.5806016901510037 0.9398359762943822 0.05002220368328427 7.303240477277607e-08 8.213584198843102e-09 0.048433800555454674 0.01614459681716294 7.342015253776922e-11 10.134184717540522 -0.4193983945188421 LLHLHFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLHLHFK 7 0 J3QR35;J3QR01;J3QRS1;A8MT69-3;A8MT69-2;A8MT69 J3QR35 STRA13 Centromere protein X 0 21511800.0 7640400.0 4889500.0 8981900.0 False True 7397859.68414352 6841902.848405656 6629270.938775809 1.0 0.9248489617977623 0.8961066067507207 22.818676506321623 -13.999999999999998 0.13316807746436596 1.3574260125043793 0.8574287422302339 0.9996315004109031 0.0008408208864513652 11.933097765585869 0.11378316567290074 1.113423649954204 0.03444306466197399 1.0000000000000041e-14 13.999999999999998 -0.4999972702741454 LLHLHFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLHLHFK 7 0 J3QR35;J3QR01;J3QRS1;A8MT69-3;A8MT69-2;A8MT69 J3QR35 STRA13 Centromere protein X 0 40767000.0 11437000.0 16560000.0 12770000.0 False True 17350765.156698737 13604738.616129447 10246003.902710173 1.0 0.784100210755084 0.5905217326254009 24.048495950267757 -6.972418513551292 0.1918126037341374 1.1281295405348444 0.24119410640267283 0.9999956137998411 0.00035023168416322456 0.0755254503190517 0.006132338775051919 0.0067296368586694565 0.020997338777211855 1.0655687770299061e-07 6.972418513551292 -0.8869354341321716 LLHLHFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLHLHFK 7 0 J3QR35;J3QR01;J3QRS1;A8MT69-3;A8MT69-2;A8MT69 J3QR35 STRA13 Centromere protein X 0 39481000.0 10383000.0 12469000.0 16629000.0 False True 14221875.690024607 11918078.350530995 12701572.685005272 1.0 0.8380103025995704 0.893101090309368 23.761608415402456 -10.257228208386529 7.321746600296094 1.0000004899542525 0.865555697550244 0.8881534821399021 0.022490719902832475 1.798825826160967e-07 1.8259748912891336e-08 0.021776625407213524 0.007258848635657159 5.5305941714208424e-11 10.257228208386529 -0.13444479240400853 LLHLHFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLHLHFK 7 0 J3QR35;J3QR01;J3QRS1;A8MT69-3;A8MT69-2;A8MT69 J3QR35 STRA13 Centromere protein X 0 15941200.0 7640400.0 4323900.0 3976900.0 False True 6353331.1271101665 4300606.292473054 4808451.402891973 1.0 0.6769057375464071 0.7568394133234975 22.5990817817559 -10.496520556305015 5.67246302069407 1.0003944694843816 0.7168725754349529 0.9435919365407274 0.032632786486490636 0.00016301747830578582 1.4469156159511866e-05 0.03163973882029916 0.01053218655020994 3.187714689168432e-11 10.496520556305015 -0.28352189404942874 LLHLHFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLHLHFK 7 0 J3QR35;J3QR01;J3QRS1;A8MT69-3;A8MT69-2;A8MT69 J3QR35 STRA13 Centromere protein X 0 51019000.0 11437000.0 22227000.0 17355000.0 False True 14805421.95697442 20990047.910896715 14196568.077337785 1.0 1.4177270983491888 0.958876289956071 23.819622272360206 -6.667113076550721 1.9477618645397565 1.2672927807614434 0.9607579974289957 0.2662891703768694 0.17756026667807973 0.46775917243488474 3.4184235064509814 0.07346566444336425 0.1970126239073756 2.1522212913955128e-07 6.667113076550721 -0.30653478333244766 LLHLLLDDMPVK(ub)PYSDGEGGIEDENR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLHLLLDDMPVKPYSDGEGGIEDENR 26 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 35310300.0 12578000.0 9270300.0 13462000.0 True False 12178718.274849119 12971979.133975852 9935898.348656744 1.0 1.065135003637036 0.8158410535840923 23.537858971854796 -6.83728217604223 1.2948383628770463 1.0346730861687559 0.8080671430075456 0.9196969338253298 0.029916111277053698 0.17199881982578033 0.561321850274112 0.018123728217530125 0.04173081652644928 1.454513725972503e-07 6.83728217604223 -0.2266059431612103 LLHLLLDDMPVK(ub)PYSDGEGGIEDENR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLHLLLDDMPVKPYSDGEGGIEDENR 26 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 60334000.0 15820000.0 25047000.0 19467000.0 True False 24000096.596919976 20577167.156895775 15619338.917310787 1.0 0.8573785140321695 0.6508031688220487 24.516536876696037 -6.965832341214676 0.34346905530884636 1.0215245187675341 0.4797558445475909 0.9999292860436286 0.0012054706946262419 0.07767965025352876 0.013870410883538168 0.0028862211129323193 0.01783537169329984 1.0818515179775722e-07 6.965832341214676 -0.5417686742199432 LLHLLLDDMPVK(ub)PYSDGEGGIEDENR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLHLLLDDMPVKPYSDGEGGIEDENR 26 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 34991100.0 12578000.0 12870000.0 9543100.0 True False 10459164.299878499 12800666.755505003 11538518.087691003 1.0 1.2238708933613085 1.1031969435478743 23.318264247289072 -10.190748795591189 4.26592150205462 0.9999435012982559 1.163533918398902 0.7100317681301979 0.04926493375012491 2.7058723986735906e-05 5.133060655591955e-06 0.047717391083913714 0.015900188992228895 6.445419733774209e-11 10.190748795591189 0.16359041710064604 LLHLLLDDMPVK(ub)PYSDGEGGIEDENR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLHLLLDDMPVKPYSDGEGGIEDENR 26 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 60031000.0 15820000.0 18283000.0 25928000.0 True False 20479301.85882094 17265534.977951355 21209370.043746106 1.0 0.8430724395282383 1.0356490758307129 24.287663198788486 -6.690058720587431 1.8664137834018704 0.901618989740506 1.0349796355875993 0.370566077887556 0.06636896780833126 0.4165652861237509 2.813539229796073 0.028448032591651965 0.0740695073065394 2.041461901681186e-07 6.690058720587431 0.13336064584709328 LLHLVWTHAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLHLVWTHAR 10 0 Q9UPT9;Q9UPT9-2 Q9UPT9 USP22 Ubiquitin carboxyl-terminal hydrolase 22 0 6669500.0 3269900.0 3399600.0 0.0 False True 3166098.814352765 4757078.0086798025 0.0 1.0 1.5025045924387157 0.0 21.594274852200417 -6.837208113368364 1.435892495318798 1.2703691597572189 8.265196344248495e-22 0.8754867882165001 0.22036465297149047 0.18719148748025644 0.774682256547737 0.12299785988839337 0.2640724958517121 1.454761793507829e-07 6.837208113368364 -1.2703691597572189 down LLHLVWTHAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLHLVWTHAR 10 0 Q9UPT9;Q9UPT9-2 Q9UPT9 USP22 Ubiquitin carboxyl-terminal hydrolase 22 0 21766700.0 1655300.0 7633400.0 12478000.0 False True 2267309.142800509 7296131.147721809 9530953.392476732 1.0 3.2179692702645117 4.203640876561013 21.112549682228344 -9.094383973646961 0.2921225665898657 9.29324596903832e-19 4.667849204897098 0.9987212691561166 0.04790840658935654 0.5355579386271612 0.10420456288163178 0.9217036986795982 0.34858245626682544 8.046666950357818e-10 9.094383973646961 4.667849204897098 LLHVAVSDVNDDVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLHVAVSDVNDDVR 14 0 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 28990100.0 7229100.0 10535000.0 11226000.0 False True 9477420.106703993 8963219.065108357 10064441.207395835 1.0 0.9457446187035744 1.061938913130653 23.1760629590585 -6.779740137690042 1.5369513366103842 0.969268862462467 1.0628507571990535 0.7664471234817665 0.022941301662137006 0.2509782991940255 1.1710197141424927 0.011756817530030897 0.027746393884143933 1.6605802268454412e-07 6.779740137690042 0.09358189473658651 LLHVAVSDVNDDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLHVAVSDVNDDVR 14 0 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 28128900.0 7229100.0 7707800.0 13192000.0 False True 9901893.62908185 7367243.90971392 10076321.297768332 1.0 0.7440237378511453 1.017615586999863 23.23927302058139 -11.057586290671194 12.11096948957894 1.5937866381705195 0.8808196624255071 0.20192324243588933 0.11169340469981115 0.04040029537344511 0.0001920991234766791 0.0024398334605564963 0.03604889135696449 8.758176827158406e-12 11.057586290671194 -0.7129669757450123 LLHVAVSDVNDDVRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLHVAVSDVNDDVRR 15 1 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 27904200.0 4516200.0 13341000.0 10047000.0 False True 6851405.578445643 10960194.316291243 8061206.046243469 1.0 1.5997001185817623 1.176576974453801 22.707968559300006 -10.392643775029907 5.017844038939942 0.9996521692695636 1.3881385465178264 0.5287383570354174 0.17273930024609135 0.0006727595320150572 8.143040694692475e-05 0.16740125776288226 0.05575136942403047 4.049078764761555e-11 10.392643775029907 0.38848637724826285 LLHVAVSDVNDDVRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLHVAVSDVNDDVRR 15 1 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 7603600.0 1513500.0 2148800.0 3941300.0 False True 2073081.8507995952 2053858.9108686342 3010446.1136214593 1.0 0.9907273608499604 1.452159794105727 20.983345648343363 -6.902316996924448 0.9465195567991287 0.982015426856785 1.5029371783239402 0.9876835577252948 0.023901539068919814 0.1097198629624744 0.16796458871036155 0.018853650872971008 0.04964866429437943 1.252226825406074e-07 6.902316996924448 0.5209217514671552 LLHVAVSDVNDDVRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLHVAVSDVNDDVRR 15 1 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 19474500.0 4516200.0 7706200.0 7252100.0 False True 5846309.927611074 7277343.195705782 5932292.212829809 1.0 1.2447754713338397 1.014707103503469 22.479094881392456 -10.940566545171107 2.807816989386607 0.9116534247501219 1.1297412874464619 0.297760245792716 0.09392501835242809 54518141.19105041 68901053.54821487 31944491.57346999 0.037127120232505764 1.146656810417526e-11 10.940566545171107 0.21808786269633995 LLIATIFLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLIATIFLNR 10 0 O95243-6;O95243-3;O95243-5;O95243-2;O95243 O95243-6 MBD4 Methyl-CpG-binding domain protein 4 0 13369500.0 2105900.0 4388800.0 6874800.0 False True 3194804.2619123743 3605584.3501490927 5515992.766668112 1.0 1.1285775448386406 1.7265510855949278 21.607296112697117 -6.941433541513971 0.6460959326326456 0.9934187909719888 1.8948378235855123 0.9983456290428369 0.01287638193083497 0.0871188051694689 0.05167812391476187 0.012674723682821305 0.051150117574113974 1.1443699851454492e-07 6.941433541513971 0.9014190326135235 LLIATIFLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLIATIFLNR 10 0 O95243-6;O95243-3;O95243-5;O95243-2;O95243 O95243-6 MBD4 Methyl-CpG-binding domain protein 4 0 9878200.0 2105900.0 3759800.0 4012500.0 False True 2726129.063495007 3550563.8248701748 3282266.1717267595 1.0 1.3024195634810516 1.2040024867783634 21.378422434789567 -10.157512402975046 4.25369054076698 0.9999346876848518 1.2532110251510384 0.8982289992412785 0.04017860338724049 28127037.046953563 2.314162632520018 18193.055979397042 0.013754204617186162 6.958050829852731e-11 10.157512402975046 0.2532763374661866 LLIEK(ub)CNTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLIEKCNTVK 10 1 P61289;P61289-3;K7ESG5;B3KQ25;K7EMD0;K7EPX6;K7EKR3 P61289 PSME3 Proteasome activator complex subunit 3 1 11594580.0 4910900.0 3774400.0 2909280.0 True False 6438237.457223257 3211274.232495964 2608255.6133843344 1.0 0.4987815770748152 0.4051195114678555 22.618234357081175 -13.999999999999998 0.2358766435097176 4.252538569743199 0.36205392856896285 0.9995183581342615 0.005731663885388117 13.481416710549668 0.15373853353639852 20.60487009418062 0.04690243944211988 1.0000000000000041e-14 13.999999999999998 -3.8904846411742358 LLIEK(ub)CNTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLIEKCNTVK 10 1 P61289;P61289-3;K7ESG5;B3KQ25;K7EMD0;K7EPX6;K7EKR3 P61289 PSME3 Proteasome activator complex subunit 3 1 6093200.0 2731200.0 1645300.0 1716700.0 True False 2644499.550983296 2302276.8701261505 1267044.770103925 1.0 0.8705907585690844 0.4791245926409039 21.334563299744367 -6.951264070651952 0.5447933441492108 1.0055885865735779 0.32589984554795576 0.9992967605611067 0.0058721741871795635 0.08298216822571497 0.03389269252499349 0.0064170315610422995 0.03244479419519061 1.1187574215918329e-07 6.951264070651952 -0.679688741025622 down LLIEK(ub)CNTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLIEKCNTVK 10 1 P61289;P61289-3;K7ESG5;B3KQ25;K7EMD0;K7EPX6;K7EKR3 P61289 PSME3 Proteasome activator complex subunit 3 1 9839500.0 4910900.0 1967900.0 2960700.0 True False 6726592.442082427 1880951.6710249376 2261443.637530526 1.0 0.27962920114759177 0.3361945378736853 22.681444418604066 -10.666394999055525 10.241809751181068 1.000265119974506 0.3079118695106386 0.9950149576590827 0.023092702017940454 0.00013984449778502636 4.555114307865528e-06 0.022367102929792358 0.00745313752786782 2.1557827919505608e-11 10.666394999055525 -0.6923532504638674 LLIEK(ub)CNTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLIEKCNTVK 10 1 P61289;P61289-3;K7ESG5;B3KQ25;K7EMD0;K7EPX6;K7EKR3 P61289 PSME3 Proteasome activator complex subunit 3 1 6550100.0 2731200.0 1742300.0 2076600.0 True False 2271113.812675158 1732913.8840805271 2510807.458886432 1.0 0.7630237966979373 1.1055401296375091 21.114968575178644 -6.7205963301966465 1.7571894071318652 0.8559164374720105 1.1050226887085985 0.5152853755548932 0.09971350432166255 0.35417862733736394 2.1375819050460256 0.04505161095238214 0.11301629287651382 1.9028461233674166e-07 6.7205963301966465 0.24910625123658803 LLIEK(ub)CNTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLIEKCNTVK 10 1 P61289;P61289-3;K7ESG5;B3KQ25;K7EMD0;K7EPX6;K7EKR3 P61289 PSME3 Proteasome activator complex subunit 3 1 18202890.0 7515600.0 5258790.0 5428500.0 True False 9729092.354624202 4966133.713652063 4440568.70111369 1.0 0.5104416252448953 0.4564216824402025 23.2138737888669 -13.999999999999998 0.31122098801104225 5.7661846264382755 0.44461438353675453 0.9996746767456968 0.004410140940124065 17.357019369457028 0.17754857408155802 53.608200658720165 0.01862656083777342 1.0000000000000041e-14 13.999999999999998 -5.321570242901521 LLIHQSLAGGIIGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLIHQSLAGGIIGVK 15 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 301699810.0 116993810.0 126820000.0 57886000.0 False True 153380017.87966773 107898950.34048818 51896512.00172049 1.0 0.7034746235662775 0.3383524967537506 27.192535302020126 -7.052735868308151 0.30809341708127724 1.060727495104933 4.355703769259028e-14 0.9999591378835778 0.001729759341380695 0.07300935201402935 0.011918545564258318 0.006228887962297038 0.03136856958229457 8.856540882150798e-08 7.052735868308151 -1.0607274951048895 down LLIHQSLAGGIIGVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLIHQSLAGGIIGVK 15 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 340259000.0 136890000.0 85839000.0 117530000.0 False True 132544501.87979777 120114960.34447138 86745367.17557767 1.0 0.9062236353900328 0.6544622066198226 26.981901585658164 -6.953916806893513 0.5140490615619542 1.0044834696008458 0.5450806899195126 0.9994738902268128 0.0033464534116686845 0.08195004831744765 0.029740578555284992 0.003828057111103201 0.020784618246860037 1.1119447101282451e-07 6.953916806893513 -0.45940277968133314 LLIHQSLAGGIIGVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLIHQSLAGGIIGVK 15 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 753504500.0 156490000.0 310600000.0 286414500.0 False True 237406770.9514547 255171003.27112368 229804548.5350651 1.0 1.0748261401664128 0.9679780724622041 27.82278584099862 -6.718464294326099 1.7650038064379485 1.0455978216754966 0.9681605181288309 0.5052147223337644 0.03149312814340887 0.3582954976954725 2.180567132283201 0.014172808791294874 0.0356412944989055 1.9122105312048487e-07 6.718464294326099 -0.07743730354666578 LLIHQSLAGGIIGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLIHQSLAGGIIGVK 15 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 416547810.0 116993810.0 99914000.0 199640000.0 False True 160249583.19583514 95499469.1085857 152489143.71486267 1.0 0.5959420748812763 0.9515727945982316 27.255745363543017 -10.227328504919663 7.825333362808249 1.0000002033116606 0.773757434739754 0.350489497793266 0.14518563336088025 5.149122654726798e-07 5.086053503169405e-08 0.14057551071119273 0.046858461676272105 5.924769992007907e-11 10.227328504919663 -0.22624276857190662 LLIHQSLAGGIIGVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLIHQSLAGGIIGVK 15 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 278482000.0 136890000.0 74597000.0 66995000.0 False True 113830100.25523677 74195131.15465485 81003344.75011873 1.0 0.6518059018510043 0.711616211955257 26.76230686109244 -10.61731522555014 6.514836548240718 1.001022569410787 0.6817110569031354 0.9742000745988524 0.0244174568521747 0.00036373853253763916 2.1366151522930906e-05 0.023712470604019546 0.007880700312100891 2.413708247804687e-11 10.61731522555014 -0.31931151250765166 LLIHQSLAGGIIGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLIHQSLAGGIIGVK 15 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 678416800.0 156490000.0 299976800.0 221950000.0 False True 202579389.87907046 283282827.3792004 181557377.3993154 1.0 1.3983793097032515 0.8962282762708282 27.59391216309107 -6.695318854430769 1.8476865779836606 1.2485083918186841 0.8978532502663235 0.39531420519835303 0.16830985190295109 0.40535528780262875 2.6870414915664025 0.07276575404813254 0.1882146812690859 2.0168850442238013e-07 6.695318854430769 -0.35065514155236066 LLIHQSLAGGIIGVK(ub)GAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLIHQSLAGGIIGVKGAK 18 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 63327000.0 19336000.0 31978000.0 12013000.0 True False 25349683.25009038 27207007.049267717 10770009.996832896 1.0 1.07326812650295 0.42485777398400026 24.595464384758543 -6.878814622697974 1.0863522722310284 1.0447398767831229 0.379930600849419 0.9727182618294538 0.04789011256859497 0.1286869881862283 0.27865468766115226 0.033992998995111365 0.08196435912625373 1.321859745666377e-07 6.878814622697974 -0.6648092759337039 down LLIHQSLAGGIIGVK(ub)GAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLIHQSLAGGIIGVKGAK 18 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 172718000.0 26484000.0 29934000.0 116300000.0 True False 40178164.23974903 24592043.8245905 93313254.02389908 1.0 0.6120748493596211 2.3224867484508533 25.259908312336655 -6.847115330712695 1.249077396364136 0.7934057538438366 2.3870945370509067 0.9359792792128757 0.18526191668753267 0.16066146722113617 0.4838387709188205 0.11614600028633133 0.2682967073327924 1.4219511253735304e-07 6.847115330712695 1.59368878320707 up LLIIASIGQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLIIASIGQLK 11 0 Q15813-2;Q15813;A0A2R8Y5Q8;A0A2R8YHI9;A0A2R8YFL4;A0A2U3TZJ6;A0A2R8Y7E7;A0A2R8Y6Q1 Q15813-2 TBCE Tubulin-specific chaperone E 0 11804400.0 7913400.0 1815900.0 2075100.0 False True 7662193.448576165 2540998.339793402 1531569.058334393 1.0 0.33162805883811053 0.19988650359891375 22.869326019489307 -13.999999999999998 0.22832056486516655 5.186705514450893 0.13480043651845586 0.9995075468935942 0.007773139126307534 13.239514395971467 0.1513076269719586 25.10494570913261 0.06910727562565276 1.0000000000000041e-14 13.999999999999998 -5.051905077932437 LLIIASIGQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLIIASIGQLK 11 0 Q15813-2;Q15813;A0A2R8Y5Q8;A0A2R8YHI9;A0A2R8YFL4;A0A2U3TZJ6;A0A2R8Y7E7;A0A2R8Y6Q1 Q15813-2 TBCE Tubulin-specific chaperone E 0 136806000.0 54535000.0 41020000.0 41251000.0 False True 82733582.04254311 33699660.50927716 33097721.76904444 1.0 0.4073274682093201 0.40005184052136156 26.301969710804162 LLIIASIGQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLIIASIGQLK 11 0 Q15813-2;Q15813;A0A2R8Y5Q8;A0A2R8YHI9;A0A2R8YFL4;A0A2U3TZJ6;A0A2R8Y7E7;A0A2R8Y6Q1 Q15813-2 TBCE Tubulin-specific chaperone E 0 13757000.0 7913400.0 2571700.0 3271900.0 False True 6580342.723060781 2557845.741657519 3956039.1624436653 1.0 0.3887101096867736 0.6011904438624062 22.649731294923583 -10.088324205602587 5.115361725162167 1.000010959296405 0.4949502767733719 0.8828082939643329 0.08674473318867518 1.084208709828074e-05 1.932328593516334e-06 0.08399204696244589 0.027996742250297142 8.159730111214614e-11 10.088324205602587 -0.5050606825230332 LLIIASIGQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLIIASIGQLK 11 0 Q15813-2;Q15813;A0A2R8Y5Q8;A0A2R8YHI9;A0A2R8YFL4;A0A2U3TZJ6;A0A2R8Y7E7;A0A2R8Y6Q1 Q15813-2 TBCE Tubulin-specific chaperone E 0 118458000.0 54535000.0 37673000.0 26250000.0 False True 70596632.54556264 35576464.43277144 21472769.347745113 1.0 0.5039399635642763 0.3041613823986111 26.07309603289661 -13.999999898221189 0.12532043401935744 3.358074575083091 0.0070171730669195305 0.9996672863656347 0.005335921895994384 11.946494689045622 0.10959795171375193 6.971285856652412 0.263888219063912 1.0000002343544008e-14 13.999999898221189 -3.3510574020161714 LLILALER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLILALER 8 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 5222900.0 1058100.0 2935300.0 1229500.0 False True 1387179.3466549749 2497364.6817097855 1102283.1341967897 1.0 1.8003185296349 0.7946219332452001 20.403722893253004 -6.694695980091573 1.8495165552989274 1.499531646910273 0.7978721894977265 0.39248646205232574 0.3381646750731649 0.40670787761837646 2.7007948683485514 0.1460667223761341 0.3781616302260667 2.0197797787967355e-07 6.694695980091573 -0.7016594574125465 LLILALER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLILALER 8 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 5147400.0 2023300.0 1502500.0 1621600.0 False True 1959071.4489984275 2102456.0854339907 1196854.3130427708 1.0 1.0731901006003983 0.6109293837418033 20.90173858420175 -6.8663871881883765 1.1529433119407837 1.0406190852676112 0.5856424109665278 0.960947545584875 0.040091174249987246 0.14037107778213062 0.35099513016202677 0.027040152819405083 0.06365100349896739 1.360231449481204e-07 6.8663871881883765 -0.45497667430108335 LLILALER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLILALER 8 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 21640700.0 5562500.0 8623800.0 7454400.0 False True 8438719.173221704 7084815.511943055 5981034.572620416 1.0 0.8395605264866564 0.7087609446229503 23.008592612964367 -6.973455060417082 0.1548211837482136 1.1421758094538097 0.40269118062377224 0.9999983243187693 0.0001540683314672265 0.07519688106708834 0.004754480974967393 0.006364942044934477 0.016006815143944236 1.063028576819903e-07 6.973455060417082 -0.7394846288300374 LLILALER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLILALER 8 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 9723800.0 1058100.0 3399100.0 5266600.0 False True 1449308.164077339 3248916.522679439 4022737.549031738 1.0 2.2417016637367593 2.7756260874944427 20.466932954775896 -9.603717185078793 0.235135147504244 3.3947595040030873e-18 3.1433678742324678 0.9992015790353106 0.021018334738595875 1.0191089643641784 0.09678109943181902 0.982859694339602 0.2538884926603254 2.490478603499332e-10 9.603717185078793 3.1433678742324678 LLILALER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLILALER 8 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 16657300.0 5562500.0 5500400.0 5594400.0 False True 7200765.903267476 5194297.904759804 4576276.603391445 1.0 0.7213535302408316 0.6355263682874176 22.779718935056817 -13.999999995858486 0.16492552769053706 2.387540947662505 0.5555770739744144 0.9995242867770361 0.003393365905382137 12.046161266458135 0.12848612730657058 5.345942499783887 0.07334392640648456 1.000000009536188e-14 13.999999995858486 -1.8319638736880905 LLINLYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLINLYK 7 0 Q9H8H0;J3QKV1 Q9H8H0 NOL11 Nucleolar protein 11 0 7028000.0 2379400.0 2268400.0 2380200.0 False True 3119416.4421423795 1929963.5621539452 2133919.7364906045 1.0 0.6186937839016032 0.684076581652257 21.57284473470328 -10.680875111658514 6.7114358138284524 1.0025151253657167 0.6513851827769362 0.9742967607486004 0.026692415407448926 0.0010102549712309608 4.803700056127299e-05 0.025991999779852292 0.008614940028591653 2.0850903980681283e-11 10.680875111658514 -0.3511299425887805 LLINLYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLINLYK 7 0 Q9H8H0;J3QKV1 Q9H8H0 NOL11 Nucleolar protein 11 0 5832300.0 1351100.0 1108200.0 3373000.0 False True 1308210.0700547502 1550710.039186656 2489510.112169006 1.0 1.185367759110551 1.9029895650205604 20.319162794175416 -6.94562719362345 0.6049606435751448 0.9919971263832021 2.133409103101638 0.9988118069962869 0.01342288762666267 0.0852908235799472 0.043607667661759185 0.01370996882473589 0.06040639868175216 1.1333728538916552e-07 6.94562719362345 1.1414119767184356 LLINLYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLINLYK 7 0 Q9H8H0;J3QKV1 Q9H8H0 NOL11 Nucleolar protein 11 0 8639800.0 2379400.0 2881300.0 3379100.0 False True 3259128.4808672382 2753994.638815061 2581026.1747490084 1.0 0.8450095339850598 0.7919375348044609 21.636054796226173 -13.999999999974374 0.1495682204366046 1.7489496114439687 0.7332569428239637 0.9995676835124951 0.001835377069419776 11.956104514638833 0.12177676696482369 2.6027662226152146 0.052869309988902574 1.0000000000590054e-14 13.999999999974374 -1.015692668620005 LLINLYK(ub)LVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLINLYKLVK 10 1 Q9H8H0;J3QKV1 Q9H8H0 NOL11 Nucleolar protein 11 1 4632320.0 1329000.0 2786900.0 516420.0 True False 1742331.870054307 2371105.383251114 462985.8122504323 1.0 1.3608804522282019 0.26572768380572725 20.732588016269133 -6.81790396585752 1.3809491933815976 1.1949220318346894 0.24287812882643603 0.8795211691801289 0.15816476270242985 0.19619463865874306 0.7357437789004997 0.09001851056179647 0.20760004048125452 1.520883800696912e-07 6.81790396585752 -0.9520439030082534 down LLINLYK(ub)LVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLINLYKLVK 10 1 Q9H8H0;J3QKV1 Q9H8H0 NOL11 Nucleolar protein 11 1 9168800.0 3568400.0 5600400.0 0.0 True False 3455123.0952434097 7836668.925700176 0.0 1.0 2.268130167775713 0.0 21.7203056795712 -6.757903525754151 1.6394620375694648 1.7410736905543778 5.023197982293374e-10 0.6699813736433777 0.5331762303442746 0.28921159783000716 1.5348028850135191 0.2575038096154415 0.6154517668431531 1.746210013211574e-07 6.757903525754151 -1.741073690052058 LLIQAAIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLIQAAIVR 9 0 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 0 29338100.0 7140100.0 10507000.0 11691000.0 False True 10832053.711230619 8631943.758434307 9380268.725652674 1.0 0.7968889361658862 0.8659732471532392 23.368803461923747 -10.458964931754975 8.344108046473291 1.0000051561127776 0.8314310916595626 0.8881235721756761 0.028203551858460733 2.705345662349777e-06 1.7540269436184596e-07 0.02730880662075621 0.009102657220976298 3.475642252935209e-11 10.458964931754975 -0.168574064453215 LLIQAAIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLIQAAIVR 9 0 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 0 21810400.0 7140100.0 8462000.0 6208300.0 False True 9243000.202412607 7991082.261304186 5078453.1025373805 1.0 0.864555023943238 0.5494377357269562 23.139929784016196 -6.956983526546982 0.4760442911578107 1.0078525580733266 0.39308959583317077 0.9996414491802916 0.0035741236048607264 0.08079677029966771 0.025250159646999948 0.004408036369630625 0.025998860648376004 1.1041205000847241e-07 6.956983526546982 -0.6147629622401558 LLISLSQGNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLISLSQGNR 10 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 110604000.0 39171000.0 34871000.0 36562000.0 False True 51353560.332503535 29668382.72609339 32778914.967468947 1.0 0.5777278641246455 0.6382987811406327 25.613960965993318 -10.428147978205502 5.9842347696308895 1.0001483114069358 0.6080133226327096 0.9824070590287245 0.024727973323605722 4.894809715630223e-05 4.677478940851853e-06 0.02395171527631797 0.007980919072315459 3.731230010343388e-11 10.428147978205502 -0.39213498877422626 LLISLSQGNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLISLSQGNR 10 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 118005000.0 48082000.0 30370000.0 39553000.0 False True 46555663.22875617 42496899.37745779 29192882.73543456 1.0 0.912819116519612 0.627053310184676 25.472453338227314 -6.949444112555967 0.5649121763025772 1.0036457381267532 0.5224537928908781 0.9991569431253481 0.004624971896580712 0.0837097096001625 0.03689190786228429 0.004928799151848841 0.023781069301466708 1.1234555329168105e-07 6.949444112555967 -0.48119194523587505 LLISLSQGNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLISLSQGNR 10 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 170726000.0 58815000.0 60954000.0 50957000.0 False True 89226654.95245573 50076282.46422423 40885326.61475352 1.0 0.5612255944247522 0.45821875353882985 26.410971419460992 -13.999999999999938 0.20358826699814386 3.473102019624493 0.39363785032670795 0.999487434419506 0.005318423731186841 12.60417197508064 0.14305381076349383 12.431791210074543 0.06387707099878448 1.0000000000001431e-14 13.999999999999938 -3.0794641692977853 LLISLSQGNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLISLSQGNR 10 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 134356000.0 39171000.0 41376000.0 53809000.0 False True 53653577.256472364 39547871.50786517 41100422.43114134 1.0 0.7370966397789331 0.766033217779217 25.67717102751621 -10.038969184437722 5.6467514662285545 1.0000009300594612 0.7515649289297558 0.989927591548872 0.011813308500800979 1.3831283620884216e-07 2.3543795386824773e-08 0.011438229551084438 0.003812728923889157 9.141781050917981e-11 10.038969184437722 -0.24843600112970543 LLISLSQGNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLISLSQGNR 10 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 85360000.0 48082000.0 19582000.0 17696000.0 False True 39982313.393763535 19476507.87927731 21396151.78294056 1.0 0.48712808804893387 0.5351404150185552 25.25285861366159 -10.274784400602545 8.626922242606385 1.0000002709013536 0.5111342523315788 0.9928178057302295 0.019600950406539964 1.0212758821388976e-07 8.588726376364434e-09 0.018978549086725277 0.006326179541197237 5.3114805978769285e-11 10.274784400602545 -0.48886601856977474 LLISLSQGNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLISLSQGNR 10 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 170279000.0 58815000.0 77344000.0 34120000.0 False True 76137176.91697565 73039738.40915985 27910510.10076437 1.0 0.9593176601334533 0.3665818885194495 26.18209774155344 -6.920785002788571 0.81889001893611 1.012712156405974 0.2692525732908963 0.9943960291099867 0.021670682686963566 0.09771226717776925 0.10323927792467252 0.01874947886170523 0.05659151892038601 1.2000932615358366e-07 6.920785002788571 -0.7434595831150776 down LLIVSNPVDILTYVAWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLIVSNPVDILTYVAWK 17 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2 P00338 LDHA L-lactate dehydrogenase A chain 0 9932100000.0 3733200000.0 3270100000.0 2928800000.0 False True 5663537333.477992 2686525105.592083 2349921396.261359 1.0 0.47435462104427967 0.414921145195006 32.39905626736615 -13.999999999999998 0.30769841086423116 6.013241335766756 0.4014318822982324 0.9996669255897251 0.0047984121605703575 17.10757087195446 0.17641415174691308 54.84026730376091 0.02079213804123612 1.0000000000000041e-14 13.999999999999998 -5.611809453468523 LLIVSNPVDILTYVAWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLIVSNPVDILTYVAWK 17 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2 P00338 LDHA L-lactate dehydrogenase A chain 0 346062000.0 170440000.0 68452000.0 107170000.0 False True 141728411.77224422 68083235.48934188 129578751.50190666 1.0 0.4803781728588816 0.914275055238311 27.078553758103848 -10.08358130708354 7.403219471951383 1.0000000497193593 0.6973266140485975 0.39350011849805666 0.17713766046900192 1.452300926205444e-07 1.7951449323758628e-08 0.17151283035866494 0.057170934081882355 8.249330299640708e-11 10.08358130708354 -0.30267343567076177 LLIVSNPVDILTYVAWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLIVSNPVDILTYVAWK 17 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2 P00338 LDHA L-lactate dehydrogenase A chain 0 7341700000.0 3733200000.0 1409800000.0 2198700000.0 False True 4832700992.373586 1331343390.6862 1798559160.5671306 1.0 0.2754863983489095 0.37216437834772115 32.17018258945859 -10.773321473934748 7.137276978743363 1.0163001437562684 0.3238253883483153 0.9848995247690053 0.039468620060014406 0.009781591316360297 0.000310661078796227 0.036514830819326195 0.012738442349185317 1.685305065210254e-11 10.773321473934748 -0.6924747554079531 LLIVSTTPYSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLIVSTTPYSEK 12 0 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 0 34472800.0 12838000.0 9522800.0 12112000.0 False True 16830742.32336886 8102035.359583678 10858766.426507954 1.0 0.481383126419463 0.6451745394159449 24.00459547264562 -10.365578638980807 5.111176807865227 1.0002497839304039 0.5632788329176628 0.9045715308247562 0.06686756434861903 0.00019043512228962176 2.3637708867293404e-05 0.06478070440861684 0.021581413593617066 4.309445185467149e-11 10.365578638980807 -0.4369709510127411 LLIVSTTPYSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLIVSTTPYSEK 12 0 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 0 25535100.0 8355000.0 5893100.0 11287000.0 False True 8089775.098295784 8246245.562110508 8330596.0972581105 1.0 1.0193417569603 1.0297685653848472 22.947668164552542 -13.999998274822426 0.07595230100087998 0.8929460666651423 1.0633787792518232 0.9999026208361249 0.00012156894272579428 12.298944097058873 0.07634393400244398 0.22560797056155948 0.030685502420260788 1.0000039723760548e-14 13.999998274822426 0.1704327125866809 LLIVSTTPYSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLIVSTTPYSEK 12 0 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 0 39250700.0 6309600.0 25456000.0 7485100.0 False True 9572124.493547803 20913177.91136419 6005666.704164121 1.0 2.1848000332069386 0.6274120973052856 23.190407729787722 -6.7033291994576825 1.8190781423677767 1.7332994885152415 0.631755083890376 0.43337561723064655 0.4998202539086764 0.38862580424947085 2.50238955007433 0.2190175733082376 0.560935301393025 1.9800255781000452e-07 6.7033291994576825 -1.1015444046248655 LLIVSTTPYSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLIVSTTPYSEK 12 0 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 0 46011000.0 12838000.0 12510000.0 20663000.0 False True 17584555.533905018 11957266.834962117 15782824.967843171 1.0 0.6799868675615457 0.8975390328980505 24.06780553416851 -10.06592988518037 5.114609196860908 1.0000035266835618 0.7887629502291258 0.5569435417570341 0.0888152995876801 3.5716767219437156e-06 6.524339583100443e-07 0.08599647911092682 0.028665014682289616 8.591522164296547e-11 10.06592988518037 -0.21124057645443606 LLIVSTTPYSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLIVSTTPYSEK 12 0 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 0 21780200.0 8355000.0 6943300.0 6481900.0 False True 6947552.689257818 6905895.064762852 7837235.3210806055 1.0 0.9940039858122449 1.128056982309526 22.72807343998682 -6.896430670530209 0.9835695709794999 0.9938677241193636 1.1411505824365322 0.9847049096650012 0.007646520232859753 0.1140800578225203 0.19261256731416784 0.0058677090564212084 0.015010736643243289 1.2693147578770916e-07 6.896430670530209 0.14728285831716859 LLIVSTTPYSEK(ub)DTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLIVSTTPYSEKDTK 15 1 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 1 7662500.0 2441800.0 2113000.0 3107700.0 True False 2364286.3955737446 2956731.919149433 2293700.1409984087 1.0 1.2505811160123512 0.9701447951874685 21.172973374910597 -6.671063238436618 1.9333050819595656 1.1597937296907401 0.9712648037371788 0.2839269377438066 0.10641447169168866 0.45866017741187287 3.3059717971044877 0.04429345260699841 0.11819005709255767 2.1327343390757178e-07 6.671063238436618 -0.1885289259535613 LLIVSTTPYSEK(ub)DTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLIVSTTPYSEKDTK 15 1 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 1 6976200.0 2441800.0 2973100.0 1561300.0 True False 2030464.8900813565 2957083.3201858555 1887760.611364437 1.0 1.4563577703958088 0.9297184209320647 20.953378650344874 -6.67751882210339 1.91047845027849 1.289377946262767 0.9317485318412695 0.3129149362351257 0.19352008497967352 0.44405214146587346 3.1313203038883097 0.0813398540708287 0.21523041956339578 2.1012666992363604e-07 6.67751882210339 -0.35762941442149754 LLK(ub)DGIQLSEYLPEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLKDGIQLSEYLPEVK 16 1 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 33227700.0 7599700.0 11861000.0 13767000.0 True False 7358451.68336547 16597159.154297872 10161009.69885286 1.0 2.255523290560899 1.3808624607569087 22.810970805209834 -10.137568171132573 4.5900993280155 0.9999106304470773 1.818192875674079 0.5384752597102245 0.35707878855490816 42444859.58019932 93742612.19472192 23618.72476880575 0.1222375736112828 7.285038124155255e-11 10.137568171132573 0.8182822452270018 LLK(ub)DGIQLSEYLPEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLKDGIQLSEYLPEVK 16 1 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 9569500.0 2167700.0 2886700.0 4515100.0 True False 2969157.2698898506 2759156.0489596496 3448726.371403411 1.0 0.9292724494388296 1.1615169079714498 21.501622081133437 -6.824990364003916 1.3501395551025215 0.9620584002518309 1.16715091437027 0.8954805293149598 0.031423696056609926 0.18707465100455958 0.668665753610805 0.018282858528441758 0.04209374634502983 1.4962688544920037e-07 6.824990364003916 0.2050925141184392 LLK(ub)DGIQLSEYLPEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLKDGIQLSEYLPEVK 16 1 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 35895400.0 7599700.0 18390000.0 9905700.0 True False 6319487.2737944545 18290929.419870816 11976936.071218016 1.0 2.8943692150025115 1.8952385774845653 22.59137608064411 -10.006114847828615 10.422274098457876 1.0000001165877974 2.3948038962435385 0.7221054010797601 0.4078933747167767 0.0 0.0 0.3949410618266019 0.13164702060886727 9.86018701563834e-11 10.006114847828615 1.394803779655741 LLK(ub)DLPELALDTPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLKDLPELALDTPR 14 1 Q53EL6;Q53EL6-2 Q53EL6 PDCD4 Programmed cell death protein 4 1 13470400.0 2719100.0 6220700.0 4530600.0 True False 4125073.4928372437 5110567.482449065 3635124.9241674794 1.0 1.2389033774363118 0.8812267055313054 21.97598839215107 -6.726678916982493 1.7350894183476033 1.1443018987725704 0.8815569477738061 0.5438411045484145 0.10045886927173087 0.3425365120549522 2.0186235901580294 0.04590890406046498 0.11436153724598395 1.8763812433834355e-07 6.726678916982493 -0.26274495099876427 LLK(ub)DLPELALDTPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLKDLPELALDTPR 14 1 Q53EL6;Q53EL6-2 Q53EL6 PDCD4 Programmed cell death protein 4 1 11878200.0 2719100.0 4558100.0 4601000.0 True False 3519928.5514740897 4304437.728108075 3763665.2102466784 1.0 1.222876449098788 1.0692447744913787 21.74711471424352 -10.15805072027146 4.884919411425732 0.9999907465909091 1.1460606117849972 0.5465174393377272 0.06271986853202424 7.69431677373619e-06 1.3260242919391995e-06 0.06073293391567332 0.02024275052320954 6.949431520084872e-11 10.15805072027146 0.14606986519408804 LLK(ub)EAGEANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLKEAGEANK 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 15120100.0 5176600.0 5435800.0 4507700.0 True False 6786572.730265704 4624799.8285824405 4041286.4449116476 1.0 0.6814632381315942 0.5954826693139154 22.69425175596719 -13.999999999999998 0.18379703929884544 2.6725648871218497 0.5297959326362934 0.9994940466427579 0.003913910303610151 12.256202903023926 0.13593354442019137 7.327631804429572 0.06218297683229397 1.0000000000000041e-14 13.999999999999998 -2.142768954485556 LLK(ub)EAGEANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLKEAGEANK 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 20071200.0 7610100.0 6246200.0 6214900.0 True False 7368521.541058135 8740340.233502695 4587031.246996491 1.0 1.1861728550022757 0.6225171795233408 22.81294374775524 -6.817713058297198 1.3819233390186447 1.1005817342579285 0.6108225473984269 0.8790052450404043 0.08156498797082674 0.19646817900929314 0.7378820300428593 0.0463910025532367 0.10698499675947144 1.5215524991334399e-07 6.817713058297198 -0.4897591868595016 LLK(ub)EAGEANK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLKEAGEANK 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 33121800.0 9659300.0 10083000.0 13379500.0 True False 14653864.289420301 8283609.871161426 10735035.960556833 1.0 0.565285013396908 0.7325737258469933 23.804777824152136 -10.075536414503306 5.067645635837679 1.0000072533835753 0.6489293696206998 0.8544843628917567 0.06829533087599565 5.596948517026544e-06 1.0208637445585744e-06 0.06612803600526329 0.022042223258248034 8.403565423569682e-11 10.075536414503306 -0.3510778837628755 LLK(ub)EAGEANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLKEAGEANK 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 15172000.0 5176600.0 5184400.0 4811000.0 True False 7090528.912354929 4955336.065481825 3674740.885655201 1.0 0.6988669148287899 0.5182604754988206 22.757461817490082 -9.913737403319304 0.09832161813988258 1.7816877025477549 1.5543521482062497e-13 0.9999381838665471 0.0015623156550496104 1.4853375506451503 0.044757011586050194 0.5579120009432865 0.26750609339514386 1.2197268853297102e-10 9.913737403319304 -1.7816877025475995 LLK(ub)EAGEANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLKEAGEANK 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 20452900.0 7610100.0 9098300.0 3744500.0 True False 6328135.334592568 9049285.652028844 4527457.63738816 1.0 1.4300082367962623 0.7154489273702705 22.593349023189518 -6.743776125317317 1.6731140945636562 1.2547298377693292 0.714695287182782 0.6216838740075457 0.18066286990690916 0.311019670945511 1.710924232311982 0.08537902968691626 0.20863068422903377 1.8039474189885533e-07 6.743776125317317 -0.5400345505865473 LLK(ub)EAGEANK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLKEAGEANK 10 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 26382000.0 9659300.0 7848000.0 8874700.0 True False 12504154.263268594 7411251.901053556 7259595.662111765 1.0 0.5927031724827946 0.5805747041554894 23.575904146244586 LLK(ub)EGSSNQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLKEGSSNQR 10 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;H7C0V6 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 2779040.0 793500.0 1088000.0 897540.0 True False 768310.7768399394 1522444.0738450477 662447.3483771633 1.0 1.9815472068566538 0.8622127508113421 19.55133046443917 -6.675042815627795 1.9194274537634517 1.623760718911726 0.8666096324645658 0.30169915790378066 0.4164576449540102 0.4495826027976337 3.197886413835908 0.17437605692272237 0.4628588753757529 2.1132806883529742e-07 6.675042815627795 -0.7571510864471602 LLK(ub)EGSSNQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLKEGSSNQR 10 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;H7C0V6 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 2959690.0 793500.0 1198100.0 968090.0 True False 659830.4080103015 1191645.597495771 1170513.1430575796 1.0 1.8059876947610554 1.7739605947946933 19.331735739873448 -10.226944681332245 4.642685948594922 0.999796502570462 1.7899741447816484 0.9987687796549566 0.01307500882456159 9215728.762167381 7.26533347436024 20048.174634163806 0.00447592329328014 5.930008538106128e-11 10.226944681332245 0.7901776422111864 LLK(ub)ELHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLKELHK 7 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 4811300.0 1141700.0 1698200.0 1971400.0 True False 1496779.7562385285 1444835.1795317533 1767418.4390041092 1.0 0.9652957781595642 1.1808139652060148 20.513430520875087 -6.865636469496712 1.1568362975364888 0.9808034997682357 1.1924365664226406 0.960135862250352 0.01886481198357476 0.141112519231328 0.35568811562603264 0.012685777078326495 0.029828671463624768 1.3625847703341946e-07 6.865636469496712 0.21163306665440496 LLK(ub)ELHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLKELHK 7 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 4624720.0 899020.0 1826900.0 1898800.0 True False 870481.1021986682 2556390.697157641 1401447.3172210245 1.0 2.936756111879613 1.6099686870642425 19.73145345231295 -10.129185426852798 4.868374060722071 0.9999348212518724 2.2733623994667185 0.5511907299969727 0.5416586980328532 0.0004313542012402049 7.715801318219017e-05 0.5244886278754576 0.1748195930611715 7.427019653379848e-11 10.129185426852798 1.273427578214846 LLK(ub)ELHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLKELHK 7 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 8853800.0 1279000.0 1262400.0 6312400.0 True False 1940336.5074248211 1037114.856823781 5064751.373176798 1.0 0.5345025735769002 2.6102438179131324 20.88787544621752 -6.847814247745242 1.2454562752833203 0.7519598719273645 2.6898475362896996 0.9370745160785579 0.2230896384855876 0.15988612884266284 0.4783338271535836 0.1402311234291101 0.3241087688714185 1.4196645971276897e-07 6.847814247745242 1.9378876643623353 up LLK(ub)ELHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLKELHK 7 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 3937500.0 1141700.0 1303100.0 1492700.0 True False 1563817.3432823932 1245524.7332245512 1140155.0031214952 1.0 0.7964643304250879 0.7290845110646703 20.576640582397978 -13.999999999989374 0.15449643631305274 1.9916182807315699 0.6586532277946848 0.9995519298223551 0.0024377188244431624 11.97753409872178 0.12400409184201666 3.5617090042641895 0.06377795507283668 1.0000000000244676e-14 13.999999999989374 -1.332965052936885 LLK(ub)ELHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLKELHK 7 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 5084220.0 899020.0 2597600.0 1587600.0 True False 747574.9633389062 2583606.2132167686 1919559.819766978 1.0 3.4559827976014152 2.567715498648613 19.511858727747228 -10.209890579976955 5.886604102392501 0.9999550702488266 3.011849148125037 0.8724454213326578 0.36263360627251523 0.00021383392516138904 2.8702725504771582e-05 0.35112618472725404 0.1170394931557039 6.167503718743721e-11 10.209890579976955 2.01189407787621 LLK(ub)ELHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLKELHK 7 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 8569000.0 1279000.0 1439200.0 5850800.0 True False 1655690.7128591659 1359107.2548415244 4786014.434277608 1.0 0.8208702532941797 2.890645213569371 20.65900176830997 -6.885836712149417 1.0467295557876617 0.8774329642289884 3.054774536435686 0.9780950772281714 0.1385812548086574 0.12258592848094503 0.24211999345235874 0.10139064278430938 0.24925488928411257 1.300658513123919e-07 6.885836712149417 2.1773415722066978 up LLK(ub)EQEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLKEQEER 8 1 Q9BY78 Q9BY78 RNF26 RING finger protein 26 1 2631900.0 0.0 0.0 2631900.0 True False 0.0 0.0 2359576.234967493 0.0 LLK(ub)EQEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLKEQEER 8 1 Q9BY78 Q9BY78 RNF26 RING finger protein 26 1 6475600.0 1088500.0 2161700.0 3225400.0 True False 1651334.080009316 1775927.74556081 2587898.276256958 1.0 1.075450308365701 1.5671560997774348 20.65520058952409 -6.934111729535635 0.7122302992151945 0.9935414223564805 1.6795537670462617 0.997286511946169 0.01309934823329126 0.09055817238428841 0.06762762021967887 0.012240824019653701 0.04352887406769992 1.1638265769961756e-07 6.934111729535635 0.6860123446897812 LLK(ub)GIPDLYDDAAIFEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLKGIPDLYDDAAIFEAK 18 1 Q14534;E7EVQ6;H0YBN7 Q14534 SQLE Squalene monooxygenase 1 13355600.0 2448500.0 3057400.0 7849700.0 True False 2370773.7077411357 4278235.764130371 5793628.084047745 1.0 1.8045736504335783 2.4437710208824157 21.176926532312756 -6.973721772138266 0.14372280492794198 0.18818193135403694 4.07688611347879 0.999998793810894 0.0006487252752815348 0.07511240056839161 0.004367200988715123 0.03476231272645903 0.08187797887738978 1.0623759432917622e-07 6.973721772138266 3.888704182124753 LLK(ub)GIPDLYDDAAIFEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLKGIPDLYDDAAIFEAK 18 1 Q14534;E7EVQ6;H0YBN7 Q14534 SQLE Squalene monooxygenase 1 4601790.0 581610.0 417480.0 3602700.0 True False 796646.9344192621 399034.3531782565 2751816.4599355618 1.0 0.5008923475857516 3.454248477013942 19.603580952957955 -6.863424147702627 1.1684183056636148 0.7263608335724371 3.606832900670262 0.9576622765438917 0.26559029687110597 0.14331005661977578 0.36985762397735716 0.17703590777924955 0.4149509138027265 1.36954356701044e-07 6.863424147702627 2.880472067097825 up LLK(ub)GIPDLYDDAAIFEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLKGIPDLYDDAAIFEAK 18 1 Q14534;E7EVQ6;H0YBN7 Q14534 SQLE Squalene monooxygenase 1 13422900.0 2448500.0 5008100.0 5966300.0 True False 2036036.23694168 4981120.371269986 7213825.744945647 1.0 2.4464792329787324 3.543073356975954 20.957331807747032 -7.672042501979764 0.18813292140882473 1.293780238301817e-16 5.245042996309794 0.9999340450279707 0.008458099138211361 0.13725118975321413 0.02324350302458089 0.20961689140744652 0.355855808581416 2.1279307870693354e-08 7.672042501979764 5.245042996309794 LLK(ub)LYCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLKLYCR 7 1 P14324;P14324-2;A0A087WVN4;A0A087X090 P14324 FDPS Farnesyl pyrophosphate synthase 1 7572200.0 1136600.0 1603100.0 4832500.0 True False 1490093.6068500553 1363923.7288348568 4332479.25661325 1.0 0.9153275489303574 2.907521538711774 20.506971532156925 -6.896974018707983 0.980206403165155 0.9101557206751814 3.1042425091199304 0.9849995591532559 0.11265632480096797 0.1136668257343603 0.19025054421177479 0.08666644233213157 0.2222538725597689 1.2677277043035452e-07 6.896974018707983 2.194086788444749 up LLK(ub)MAQGHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLKMAQGHR 9 1 E9PHA2;Q15003;Q15003-2;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 1 1362770.0 324550.0 584740.0 453480.0 True False 425488.1929466709 497499.0712986682 406558.2396873205 1.0 1.1692429532610389 0.9555100386493615 18.698759572943526 -6.695641570733716 1.8461316370477627 1.105536703352211 0.9561893161275938 0.3970527297569578 0.07149783591041325 0.40465767732123503 2.678041760474775 0.03093130388096695 0.07998623062201152 2.0153868904530538e-07 6.695641570733716 -0.14934738722461716 LLK(ub)MAQGHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLKMAQGHR 9 1 E9PHA2;Q15003;Q15003-2;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 1 1934080.0 324550.0 686600.0 922930.0 True False 444544.9056339673 656263.7417174258 704952.9423400033 1.0 1.4762597285453656 1.5857856729561821 18.761969634466418 -11.794672556786061 0.24813735917869748 2.746830665400109e-09 1.6358487363668524 0.9993493107482523 0.006486545866402265 4.654655328456954 0.1427428280226073 2.478917196624044 0.050919016180694276 1.6044546387935937e-12 11.794672556786061 1.6358487336200216 LLK(ub)NHDEESLECLCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLKNHDEESLECLCR 15 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;A0A0A0MSA7;O43432;O43432-3;A0A0U1RQK7;O43432-4 Q04637-7 EIF4G1;EIF4G3 Eukaryotic translation initiation factor 4 gamma 1;Eukaryotic translation initiation factor 4 gamma 3 1 13287000.0 3842900.0 0.0 9444100.0 True False 5829960.253622242 0.0 7577469.4955039155 1.0 0.0 1.2997463388872883 22.475054617055683 -6.701231294234244 1.8268045347520898 0.3797708342255411 1.2959244521370061 0.42324455891537127 0.42202054175169124 0.39298371514375824 2.5506129587622683 0.1842533346448265 0.4730747585628403 1.9896134390817002e-07 6.701231294234244 0.9161536179114651 LLK(ub)NHDEESLECLCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLKNHDEESLECLCR 15 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;A0A0A0MSA7;O43432;O43432-3;A0A0U1RQK7;O43432-4 Q04637-7 EIF4G1;EIF4G3 Eukaryotic translation initiation factor 4 gamma 1;Eukaryotic translation initiation factor 4 gamma 3 1 8427100.0 1797000.0 3829800.0 2800300.0 True False 2461399.462099026 3660586.7725450015 2138926.8139888304 1.0 1.4871973561834355 0.8689880886561996 21.231047382025793 -6.696608564544133 1.8430776946467793 1.3035352383456211 0.8709477349820262 0.40142006600920455 0.20578324149409774 0.4026345925230932 2.656638689861195 0.08915723946489786 0.23024397223815252 2.010904451278592e-07 6.696608564544133 -0.43258750336359497 LLK(ub)NHDEESLECLCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLKNHDEESLECLCR 15 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;A0A0A0MSA7;O43432;O43432-3;A0A0U1RQK7;O43432-4 Q04637-7 EIF4G1;EIF4G3 Eukaryotic translation initiation factor 4 gamma 1;Eukaryotic translation initiation factor 4 gamma 3 1 13326200.0 3842900.0 0.0 9483300.0 True False 4974709.804883886 0.0 7757436.706875107 1.0 0.0 1.5593747195583747 22.246180939148132 -6.733518344288234 1.710534085097359 0.40057874032943763 1.5590420550390942 0.5754766949327683 0.4202708873762796 0.3296627371395876 1.8912429350262951 0.19458611302638212 0.48091647973155427 1.8470627746515914e-07 6.733518344288234 1.1584633147096566 LLK(ub)QDIEASSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLKQDIEASSLK 12 1 Q96AP4;Q96AP4-2 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 14935800.0 3241200.0 8637900.0 3056700.0 True False 4249244.5878254445 7349158.990270485 2740422.0059368256 1.0 1.7295212921672332 0.6449198085204221 22.01877495733572 -6.725443328659681 1.739372136315433 1.441216857321597 0.6460242038721425 0.5382617587232879 0.30679800193027995 0.34482995420993284 2.041537072146592 0.1398880373000641 0.34899037499654106 1.881727237883331e-07 6.725443328659681 -0.7951926534494546 LLK(ub)QDIEASSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLKQDIEASSLK 12 1 Q96AP4;Q96AP4-2 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 17752100.0 5408500.0 6536500.0 5807100.0 True False 5236810.127963228 9146558.53739719 4286046.300734254 1.0 1.7465896822489142 0.8184459997600183 22.320256866986803 -6.692561968941947 1.857082542840983 1.4669241425484199 0.8215280111620897 0.382578868735462 0.3155906934765396 0.41116719975182514 2.751173292003897 0.13584228689559236 0.35263460838421823 2.0297288796950291e-07 6.692561968941947 -0.6453961313863301 LLK(ub)QDIEASSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLKQDIEASSLK 12 1 Q96AP4;Q96AP4-2 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 21409600.0 7850100.0 4241900.0 9317600.0 True False 11909175.619183416 3484899.802884031 7475972.275950844 1.0 0.29262309284200333 0.6277489320006732 23.505570214165953 -10.583903783438265 6.513881500306233 1.001051580892657 0.460186012422314 0.7757587488906005 0.13681455092679448 0.0020929240684661177 0.0001336922654472762 0.13269505950418095 0.04415670643819346 2.6067309989959186e-11 10.583903783438265 -0.540865568470343 LLK(ub)QDIEASSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLKQDIEASSLK 12 1 Q96AP4;Q96AP4-2 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 10377500.0 3241200.0 3800800.0 3335500.0 True False 4439559.230136536 3632868.088435175 2547723.5967788226 1.0 0.8182947675919279 0.5738685902610356 22.08198501885861 -6.9670044194254235 0.321802694432025 1.0327738434872733 0.35148474036690863 0.9999486977380255 0.0012505296873390236 0.07728723017109936 0.012495776323223894 0.0036783461415652134 0.02146629780228654 1.0789357428126083e-07 6.9670044194254235 -0.6812891031203647 LLK(ub)QDIEASSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLKQDIEASSLK 12 1 Q96AP4;Q96AP4-2 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 17336800.0 5408500.0 10370800.0 1557500.0 True False 4497407.387175456 10314930.441957373 1883166.0489336539 1.0 2.293528149433566 0.41872258543968693 22.10066214242108 -6.7210821980084345 1.755559354549747 1.7860559837049377 0.42149220205857063 0.5175772273268391 0.544249283604125 0.3532096589129439 2.1280624828246024 0.24610843191454684 0.617006995288723 1.9007185008610023e-07 6.7210821980084345 -1.3645637816463672 LLK(ub)QDIEASSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLKQDIEASSLK 12 1 Q96AP4;Q96AP4-2 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 21422200.0 7850100.0 10020500.0 3551600.0 True False 10162109.198604954 9462850.366272582 2905245.2424933957 1.0 0.9311895967002238 0.2858899846197505 23.276696536258402 -6.927266813195691 0.7689070336169793 1.010872188066526 0.16219017825947243 0.9959729992093542 0.020411158239178384 0.09408241212263914 0.08481979924237351 0.01830157402494091 0.05929040041493223 1.1823149654289435e-07 6.927266813195691 -0.8486820098070534 down LLK(ub)SSHPEDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLKSSHPEDLR 11 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 8553400.0 3218400.0 3430200.0 1904800.0 True False 4219353.567029937 2918427.5308148745 1707709.5681317968 1.0 0.6916764581237018 0.40473251198379134 22.008590554731228 -7.148302599506467 0.2227530179637371 1.138575873343977 2.374153288292684e-13 0.9999856568899802 0.0009205407351202166 0.08274772015439368 0.009412525956580816 0.010787938995425782 0.03374311245876389 7.107181403326358e-08 7.148302599506467 -1.1385758733437397 down LLK(ub)SSHPEDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLKSSHPEDLR 11 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 16338700.0 3903900.0 6330500.0 6104300.0 True False 3779972.831386817 8858301.663121376 4505400.704925367 1.0 2.3434828921432733 1.1919135152282034 21.84994443441487 -6.608608796912114 2.1583582659298512 1.8984039351882118 1.195941485414403 0.04619494856097728 0.5794200773400066 0.6165374421174447 5.440337700786871 0.22181651964696267 0.6435970821273425 2.462584848610845e-07 6.608608796912114 -0.7024624497738088 LLK(ub)SSHPEDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLKSSHPEDLR 11 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 22462600.0 7255300.0 6257400.0 8949900.0 True False 11006820.533478737 5140718.08071065 7180948.342119477 1.0 0.4670484146692916 0.6524089604511719 23.39189445163996 -10.170141564214948 6.273473572188541 1.0000027392050377 0.5597286875602313 0.8826594156117976 0.0756731259349056 2.8991991296237316e-06 3.8349332103812064e-07 0.07327064429549399 0.024423396375111536 6.758626328307008e-11 10.170141564214948 -0.4402740516448064 LLK(ub)SSHPEDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLKSSHPEDLR 11 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 10823500.0 3218400.0 4444100.0 3161000.0 True False 4408329.453989711 4247744.967326552 2414436.9028385165 1.0 0.9635724851467661 0.5476988342269556 22.07180061625412 -6.924126543204783 0.7935279119375591 1.007884756893337 0.4738300091452577 0.9952523430080441 0.014136907968296758 0.0958044880477623 0.09347772301241089 0.012454564144615468 0.038915162167478104 1.190894958667522e-07 6.924126543204783 -0.5340547477480793 LLK(ub)SSHPEDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLKSSHPEDLR 11 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 18411900.0 3903900.0 11265000.0 3243000.0 True False 3246265.822093782 11204313.209072568 3921096.3060621754 1.0 3.451446623014375 1.2078789972698971 21.630349709849146 -6.62508342002642 2.0982441368768034 2.620778400345348 1.2166949918523615 0.1001217609820182 1.0528485188015873 0.5718947728650796 4.791387729613771 0.4113165084300454 1.1667896578429835 2.370918251890472e-07 6.62508342002642 -1.4040834084929865 LLLAGYDDFNCNIWDAMK(ub)GDR ddPTM_RPMI8226_Bortezomib_8h_R1 2 LLLAGYDDFNCNIWDAMKGDR 21 1 P62879;E7EP32;P62879-2 P62879;P62879-2 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 339592900.0 15304000.0 72100900.0 252188000.0 True False 23217286.872266963 59233931.06809712 202342931.26207286 1.0 2.5512856602918585 8.715184180446656 24.468696055681995 -6.945027864847035 0.6109994225911944 0.9319153782164039 10.65610221976875 0.9987510454039582 0.11775718304494011 0.0855458890744514 0.04471390314138152 0.11958448352007461 0.5199391134695187 1.1349379943736525e-07 6.945027864847035 9.724186841552346 LLLAGYDDFNCNIWDAMK(ub)GDR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LLLAGYDDFNCNIWDAMKGDR 21 1 P62879;E7EP32;P62879-2 P62879;P62879-2 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 269410600.0 15304000.0 40547600.0 213559000.0 True False 19811329.686940312 38291090.415795036 174693453.30038497 1.0 1.9327875019432257 8.817856048074523 24.239822377774445 -6.93162596766544 0.7333217872318577 0.9013579819043271 10.291692949652129 0.9968482709608881 0.19572586233759848 0.09180237365362566 0.07360808149721816 0.18007200476239596 0.6175045268005912 1.1705070460246025e-07 6.93162596766544 9.390334967747801 LLLAGYDDFNCNVWDALK(ub)ADR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLLAGYDDFNCNVWDALKADR 21 1 P62873;P62873-2;B3KVK2 P62873;B3KVK2 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 1 181398000.0 10019000.0 50139000.0 121240000.0 True False 15199555.487012723 41191303.71220498 97276860.85862029 1.0 2.710033444557042 6.399980640337713 23.85752579669226 -6.958532517375411 0.45564427435786875 0.8876369619021208 8.370044535678025 0.9997118413886551 0.03825174838085688 0.08022955731223598 0.023100108789835434 0.04975347799092998 0.30498305258975295 1.100189466599362e-07 6.958532517375411 7.4824075737759035 LLLAGYDDFNCNVWDALK(ub)ADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLLAGYDDFNCNVWDALKADR 21 1 P62873;P62873-2;B3KVK2 P62873;B3KVK2 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 1 122845000.0 10019000.0 23450000.0 89376000.0 True False 12969793.004015617 22144986.885793302 73110485.07520255 1.0 1.7074279349668051 5.636981642850167 23.62865211878471 -6.937488166562581 0.6825295137413048 0.9533913037398685 6.62269068178978 0.9978160751130446 0.09532032074637298 0.08893141820043497 0.05996907100794274 0.09110818222004442 0.34211957988940594 1.1548134500363343e-07 6.937488166562581 5.669299378049911 LLLAGYDDFNCNVWDTLK(ub)GDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLLAGYDDFNCNVWDTLKGDR 21 1 Q9HAV0 Q9HAV0 GNB4 Guanine nucleotide-binding protein subunit beta-4 1 109811000.0 12782000.0 33065000.0 63964000.0 True False 19391228.489369884 27164292.411975883 51321487.36358292 1.0 1.400854640378619 2.6466341413962993 24.20890086937771 -6.9506546329062475 0.5516137711624741 0.9829337464345966 3.123241766898005 0.999251634710092 0.019179876333378542 0.08322401548059338 0.034883224390361595 0.02077447898253567 0.10337974125458857 1.120328456088776e-07 6.9506546329062475 2.140308020463408 up LLLAGYDDFNCNVWDTLK(ub)GDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLLAGYDDFNCNVWDTLKGDR 21 1 Q9HAV0 Q9HAV0 GNB4 Guanine nucleotide-binding protein subunit beta-4 1 96294000.0 12782000.0 14215000.0 69297000.0 True False 16546550.970888093 13423922.754010746 56685657.047264606 1.0 0.8112822290052301 3.425829174128012 23.98002719147016 -6.889547800659205 1.025028860766129 0.8579910249497541 3.6487433359344803 0.9806081794124663 0.16578578478274375 0.11951182383441805 0.22398446699012436 0.12330553838143113 0.30691394023504537 1.2895916110764972e-07 6.889547800659205 2.7907523109847263 up LLLAVFVTPLTDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLLAVFVTPLTDLR 14 0 A0A2R8YFH0;E9PHA6;A0A2R8Y6P0;A0A2R8YG02;P43246;P43246-2;A0A2R8Y7S8 A0A2R8YFH0 MSH2 DNA mismatch repair protein Msh2 0 853110000.0 256500000.0 336970000.0 259640000.0 False True 389129252.66181934 276835070.7413732 208322040.19574523 1.0 0.7114218960607475 0.5353543553221164 28.535674197605026 -9.722270208591397 0.09553611029028605 1.754712443404147 3.5216702538047182e-12 0.9999501424783577 0.0013524172334074696 1.2342601676119298 0.04085207011161893 0.4912612789544085 0.261403859766233 1.8955261990305727e-10 9.722270208591397 -1.7547124434006254 LLLAVFVTPLTDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLLAVFVTPLTDLR 14 0 A0A2R8YFH0;E9PHA6;A0A2R8Y6P0;A0A2R8YG02;P43246;P43246-2;A0A2R8Y7S8 A0A2R8YFH0 MSH2 DNA mismatch repair protein Msh2 0 707860000.0 256500000.0 138830000.0 312530000.0 False True 332044306.3708962 131103988.45862187 255652746.8286011 1.0 0.3948388391041334 0.769935643898784 28.306800519697475 -10.098608184963073 5.233971651313006 1.0000079967690152 0.5823872415010097 0.6230285688644136 0.15313262931764213 1.4289758826427179e-05 2.460877819264533e-06 0.14827286736158074 0.04942334359209368 7.968779595133225e-11 10.098608184963073 -0.41762075526800546 LLLDGAPLIAIHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLDGAPLIAIHK 13 0 K7EMY7;K7ER15;Q9H0R4;Q9H0R4-2 K7EMY7 HDHD2 Haloacid dehalogenase-like hydrolase domain-containing protein 2 0 5747600.0 1342700.0 3123300.0 1281600.0 False True 1760292.7027252947 2657315.814528047 1148992.3259752805 1.0 1.5095874739547441 0.6527279947229255 20.747383910493404 -6.745568927853383 1.665993227895959 1.3012221946937383 0.6515565828011909 0.629823010104481 0.2141019624276793 0.307821669315765 1.679472562037605 0.10157711738685912 0.24778417866975216 1.7965159284645376e-07 6.745568927853383 -0.6496656118925475 LLLDGAPLIAIHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLDGAPLIAIHK 13 0 K7EMY7;K7ER15;Q9H0R4;Q9H0R4-2 K7EMY7 HDHD2 Haloacid dehalogenase-like hydrolase domain-containing protein 2 0 6121700.0 2550500.0 1548100.0 2023100.0 False True 2469535.773573115 2166264.403234851 1493189.4183009553 1.0 0.8771949879877757 0.6046437691973555 21.235808437000934 -6.95795995854429 0.4632983598548108 1.0076880496154366 0.46310281951139515 0.9996868653346312 0.0029236212881719875 0.0804381997747793 0.02388689120847101 0.0037227447147788768 0.022507795419493798 1.1016408748909528e-07 6.95795995854429 -0.5445852301040415 LLLDGAPLIAIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLDGAPLIAIHK 13 0 K7EMY7;K7ER15;Q9H0R4;Q9H0R4-2 K7EMY7 HDHD2 Haloacid dehalogenase-like hydrolase domain-containing protein 2 0 8071500.0 1342700.0 2373400.0 4355400.0 False True 1839132.4751031494 2268535.3402157575 3326744.222278667 1.0 1.233481204277318 1.8088660100964633 20.810593972016296 -6.955768688994309 0.4914543121070736 0.9875725160327823 2.0792337776402987 0.9995796517328029 0.006968954165740137 0.08124875503085707 0.026991189551999223 0.008310405285437006 0.047456167978803906 1.1072133434835115e-07 6.955768688994309 1.0916612616075163 LLLEEDENEESGSIK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLEEDENEESGSIKR 16 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 14213400.0 3750500.0 5616700.0 4846200.0 True False 4916941.819893659 4778710.253725116 4344761.712032927 1.0 0.9718866785022214 0.8836308972488296 22.229329853779532 -6.950426795041916 0.5541461737115976 1.0011916169775832 0.8501502944919551 0.9992342854891927 0.0013718694303333399 0.08331497349874185 0.03525773829827015 0.0014811862710061715 0.007327464165626079 1.1209163525970456e-07 6.950426795041916 -0.15104132248562807 LLLEEDENEESGSIK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLEEDENEESGSIKR 16 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 16194500.0 5231700.0 4437600.0 6525200.0 True False 5065622.547187796 6209556.821778289 4816054.368196028 1.0 1.2258230383204436 0.950732969804409 22.272308151390828 -6.688516610454209 1.871297436615185 1.1417670624164549 0.9516892671487388 0.3637164259568023 0.09553523434246178 0.4198368259266485 2.8491214623039682 0.04085586133387823 0.10660615873430963 2.048723690956278e-07 6.688516610454209 -0.19007779526771607 LLLEEDENEESGSIK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLLEEDENEESGSIKR 16 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 67481000.0 13143000.0 20065000.0 34273000.0 True False 19938891.88200503 16484243.981439438 27498926.527610436 1.0 0.8267382199066222 1.379160220655411 24.24908189737999 -6.822396078756924 1.3613669834441933 0.9068321048447199 1.3918628000998348 0.8898334835871554 0.0765684105181527 0.1903814368711132 0.6926267584164422 0.044189233988591564 0.10179530286459108 1.505233659319242e-07 6.822396078756924 0.4850306952551149 LLLEEDENEESGSIK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLEEDENEESGSIKR 16 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 14969700.0 3750500.0 4220600.0 6998600.0 True False 5137161.203451523 4034119.9363422147 5345674.820691441 1.0 0.7852819439716621 1.0405892688553016 22.292539915302424 -6.683731756140366 1.8889843886616602 0.8645975639341689 1.039638312991035 0.3410723949079416 0.0909302407706845 0.43031641677781945 2.971917035206471 0.038583785634567956 0.10126500233780275 2.0714203754800791e-07 6.683731756140366 0.17504074905686606 LLLEEDENEESGSIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLLEEDENEESGSIKR 16 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 16947700.0 5231700.0 6908000.0 4808000.0 True False 4350390.353607435 6870785.23286935 5813330.570319745 1.0 1.5793491329282558 1.3362779194053722 22.052713426825104 -10.072313626505796 4.5361020366113305 0.999975296219742 1.4578135258475808 0.8254758747946547 0.09923340747843702 68885677.29043885 0.534056434026805 20400.117577667053 0.033970234819106895 8.466158082714675e-11 10.072313626505796 0.4578382296278388 LLLEEDENEESGSIK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLLEEDENEESGSIKR 16 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 60667000.0 13143000.0 16857000.0 30667000.0 True False 17013872.58726194 15918893.131506095 25085920.669992384 1.0 0.9356419621611811 1.4744391990318464 24.02020821947244 -6.8770724177296225 1.0959394564168057 0.9614612743204719 1.510551282343649 0.9712488552435949 0.040739391840385566 0.1302576842501918 0.28819356595106443 0.028705508140804917 0.06893260703630193 1.3271731358320178e-07 6.8770724177296225 0.5490900080231772 LLLETHLPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLETHLPSK 10 0 A0A494C128;O00567;Q5JXT2 A0A494C128 NOP56 Nucleolar protein 56 0 3467900.0 1311000.0 2156900.0 0.0 False True 1718733.6957420583 1835098.9275303518 0.0 1.0 1.0677040498342316 0.0 20.712914597214713 -6.978129277811472 1.1562724901984638 1.0458675218525084 6.374965033617208e-22 0.9793513159745396 0.07014482421839018 0.09761042946591056 0.257253223828118 0.050867790467591566 0.09461757631976783 1.0516487796085968e-07 6.978129277811472 -1.0458675218525084 down LLLETHLPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLETHLPSK 10 0 A0A494C128;O00567;Q5JXT2 A0A494C128 NOP56 Nucleolar protein 56 0 2896400.0 1311000.0 1585400.0 0.0 False True 1795712.128442861 1515351.7857832883 0.0 1.0 0.8438723344244018 0.0 20.776124658737604 -7.186532994136626 0.9041160205161031 0.9914708391566807 2.3846534801669734e-19 0.9894663137564236 0.045082279806181395 0.09138079558158106 0.14177824777549503 0.03792114538124856 0.0665609974904192 6.508291642944032e-08 7.186532994136626 -0.9914708391566807 down LLLETHLPSKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLETHLPSKK 11 1 A0A494C128;O00567;Q5JXT2 A0A494C128 NOP56 Nucleolar protein 56 1 6560300.0 1540600.0 1901300.0 3118400.0 True False 2019741.5191916225 1617633.4512093521 2795737.881805018 1.0 0.8009111244377403 1.3842057784324693 20.945739242082773 -6.814595792121276 1.3951458141661315 0.8920708991975279 1.395516643525078 0.8714780412138474 0.08679040062623718 0.2006047840721556 0.768649915019269 0.04890295692699146 0.1129048176679848 1.5325131434072763e-07 6.814595792121276 0.5034457443275502 LLLETHLPSKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLETHLPSKK 11 1 A0A494C128;O00567;Q5JXT2 A0A494C128 NOP56 Nucleolar protein 56 1 8466200.0 1519500.0 2318600.0 4628100.0 True False 1471264.3042322474 3244429.071339269 3415861.769976095 1.0 2.205197979728269 2.321718647118677 20.488625011126285 -10.726900080341931 0.44495968718038265 2.0604228629381635e-10 2.324080676161796 0.9995528310478669 0.01263488216824325 2.293588805499857 0.2135534486454316 2.503979179334563 0.02653257899686088 1.8754259442739272e-11 10.726900080341931 2.3240806759557535 LLLETHLPSKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLLETHLPSKK 11 1 A0A494C128;O00567;Q5JXT2 A0A494C128 NOP56 Nucleolar protein 56 1 27913800.0 1810900.0 4279900.0 21823000.0 True False 2747267.69452354 3516118.405988669 17509674.484639313 1.0 1.2798601363084392 6.373486835499671 21.389566063190866 -6.918236683763089 0.8376985618032976 0.8803115288334779 7.162470660126794 0.9936769597224916 0.19638976705420763 0.09922051888417835 0.1110717084514147 0.16764852396090094 0.49402702954753014 1.207155774614827e-07 6.918236683763089 6.282159131293316 up LLLETHLPSKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLLETHLPSKK 11 1 A0A494C128;O00567;Q5JXT2 A0A494C128 NOP56 Nucleolar protein 56 1 7047300.0 1519500.0 2872900.0 2654900.0 True False 1263531.5752635836 2857423.117474001 3210027.3151293453 1.0 2.2614576267141704 2.5405200613682375 20.26903028656056 -10.373011294853141 0.32715210127618555 1.293503682879797e-21 2.609337204067731 0.999039950104656 0.020765517654049753 1.8551044263528618 0.15456589077870253 1.6779999552443 0.08968949222540959 4.236319483574837e-11 10.373011294853141 2.609337204067731 LLLETHLPSKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLLETHLPSKK 11 1 A0A494C128;O00567;Q5JXT2 A0A494C128 NOP56 Nucleolar protein 56 1 21577900.0 1810900.0 3170000.0 16597000.0 True False 2344245.7481756546 2993586.7133460487 13576516.29960099 1.0 1.2769935556780794 5.7914219574319565 21.160692385283316 -6.919443278898232 0.8288349576572652 0.8983799412089319 6.5101978442634145 0.9940250983307137 0.1697702530786114 0.09850053494848247 0.10731638599538665 0.1458449334121589 0.434583527935675 1.2038066028826287e-07 6.919443278898232 5.611817903054483 up LLLGAGAVAYGVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLGAGAVAYGVR 13 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6;F5H2D2;F5H0C5 Q99623 PHB2 Prohibitin-2 0 38933000.0 12487000.0 16087000.0 10359000.0 False True 16370577.92428001 13686882.306634875 9287150.050544567 1.0 0.8360659208209862 0.5673074031656719 23.9646019178364 -6.963738133567364 0.37908694721571845 1.0186516857188903 0.3752314244899133 0.9998847211966339 0.0019150658852538573 0.07839183055902106 0.016386157770699603 0.003500987373576487 0.022719835712513917 1.0870809029343171e-07 6.963738133567364 -0.643420261228977 LLLGAGAVAYGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLGAGAVAYGVR 13 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6;F5H2D2;F5H0C5 Q99623 PHB2 Prohibitin-2 0 39383900.0 18121000.0 7569900.0 13693000.0 False True 17545758.7739339 10592600.546506993 10106392.518805286 1.0 0.6037128791627658 0.5760020212872989 24.064619003272295 -13.999999999999998 0.37776171057651037 6.79686018337262 0.5734714767007637 0.9998038860908556 0.0027122140087056756 23.75419492082102 0.2002176525542379 111.87879703505544 0.007561426283441407 1.0000000000000041e-14 13.999999999999998 -6.223388706671856 LLLGAGAVAYGVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLLGAGAVAYGVR 13 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6;F5H2D2;F5H0C5 Q99623 PHB2 Prohibitin-2 0 122026000.0 17113000.0 54866000.0 50047000.0 False True 25961672.127881933 45074733.62998537 40155188.513620704 1.0 1.7362030229777332 1.5467104089376211 24.62987997100444 -10.11281114174181 4.565330119930742 0.9999530799087265 1.641456715917681 0.9385703606772604 0.07736003602112357 9128031.349398606 20219803.20342513 3121.972694238705 0.026482398634672586 7.712387787521536e-11 10.11281114174181 0.6415036360089544 LLLGAGAVAYGVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLGAGAVAYGVR 13 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6;F5H2D2;F5H0C5 Q99623 PHB2 Prohibitin-2 0 41969000.0 12487000.0 12357000.0 17125000.0 False True 17103781.348486662 11811026.880865477 13080427.700445909 1.0 0.6905506238777143 0.7647681780966676 24.027811979359292 -10.31964710358433 6.116823109660676 1.000018772152292 0.7276594009871914 0.9472394221447406 0.030299189632297503 7.757152189221878e-06 8.627717953276709e-07 0.029339084311757115 0.009779021404122274 4.7901917276068646e-11 10.31964710358433 -0.27235937116510056 LLLGAGAVAYGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLLGAGAVAYGVR 13 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6;F5H2D2;F5H0C5 Q99623 PHB2 Prohibitin-2 0 35696100.0 18121000.0 9892300.0 7682800.0 False True 15068414.396414217 9839008.216432186 9289237.95874636 1.0 0.652955776075122 0.6164708319248833 23.84502427870657 -13.999999999999998 0.318224785492677 4.521101997451276 0.6090831094392406 0.9996899089320742 0.0030436177298350186 17.876605381127575 0.17982263162250134 41.86725495813987 0.012232083643582005 1.0000000000000041e-14 13.999999999999998 -3.9120188880120352 LLLGAGAVAYGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLLGAGAVAYGVR 13 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6;F5H2D2;F5H0C5 Q99623 PHB2 Prohibitin-2 0 117732000.0 17113000.0 56197000.0 44422000.0 False True 22153115.8476614 53069587.548866734 36337651.80821084 1.0 2.3955811865836942 1.6402953001325473 24.401006293096888 -10.060317684969855 4.9681728070933575 0.9999781618541982 2.017938243365089 0.7077659552054685 0.30834417197929875 7.458610586015074e-05 1.4108531783873841e-05 0.2985593478304693 0.09951765357787876 8.703267159492447e-11 10.060317684969855 1.017960081510891 LLLGTLHLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLGTLHLPR 10 0 A0A0C4DFX9;Q9H3P2;H7C3C2;F8W954;F8WF98;H7C2M8;H7C0W2;C9JHL4 A0A0C4DFX9 NELFA Negative elongation factor A 0 13110500.0 6727900.0 3827000.0 2555600.0 False True 8820342.053076282 3256026.517529159 2291171.027046213 1.0 0.3691496880660711 0.2597598838298021 23.0724031739401 -13.999999999999998 0.24648791576503384 5.310795021149362 0.21428280400382674 0.99953621291837 0.007025812820866514 13.861487467941902 0.15710969507817876 29.52444533466108 0.051487869822549576 1.0000000000000041e-14 13.999999999999998 -5.096512217145535 LLLGTLHLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLGTLHLPR 10 0 A0A0C4DFX9;Q9H3P2;H7C3C2;F8W954;F8WF98;H7C2M8;H7C0W2;C9JHL4 A0A0C4DFX9 NELFA Negative elongation factor A 0 10125500.0 3392400.0 2301400.0 4431700.0 False True 3284710.1189058777 3220361.021642455 3270904.8218498 1.0 0.9804095049687802 0.9957971033801071 21.64733462526896 -10.009851360838343 4.718754088464475 1.0000002530220777 0.9881033041739792 0.44351190140721 0.006281960747362217 8667515.524600442 0.23056165886060295 23.832151731646093 0.0021504822539431833 9.775717418566076e-11 10.009851360838343 -0.011896948848098554 LLLGTLHLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLGTLHLPR 10 0 A0A0C4DFX9;Q9H3P2;H7C3C2;F8W954;F8WF98;H7C2M8;H7C0W2;C9JHL4 A0A0C4DFX9 NELFA Negative elongation factor A 0 18833800.0 6727900.0 6240600.0 5865300.0 False True 9215386.444661126 5964869.65709549 4480036.939645279 1.0 0.6472728727020665 0.4861474845952618 23.13561323546299 -13.999999999992548 0.10538327844683662 2.7177753656637607 0.16990759260622923 0.9997665300802483 0.003278800993479387 12.041768271407847 0.09772170366063802 4.442095663693698 0.2813071110693815 1.0000000000171585e-14 13.999999999992548 -2.5478677730575314 LLLIGDSGVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLIGDSGVGK 11 0 E9PLD0;Q9H0U4;Q92928;A0A2R8YDI9;H0YLJ8;H0YL94;H0YMN7;H0YNE9;G3V196;A0A2R8YFB8;P51153;Q92930;P61006-2;P59190-2;P59190;P61026;E7END7;P62820-2;P62820;P62820-3;P61006 E9PLD0;P61026;E7END7;P61006 RAB1B;RAB1C;RAB8B;RAB15;RAB13;RAB8A;RAB10;RAB1A Ras-related protein Rab-1B;Putative Ras-related protein Rab-1C;Ras-related protein Rab-13;Ras-related protein Rab-8B;Ras-related protein Rab-8A;Ras-related protein Rab-15;Ras-related protein Rab-10;Ras-related protein Rab-1A 0 14886700.0 3597100.0 4538500.0 6751100.0 False True 4715832.9343659505 3861373.4909344353 6052560.933123993 1.0 0.818810493220664 1.2834553338428998 22.169081178856644 -6.800999257830243 1.452305282830344 0.9001557656470125 1.2899933409722146 0.8349282435774856 0.07768911860315651 0.21934327063428136 0.9133271341579701 0.042085421516579916 0.09779534096084208 1.581250741481726e-07 6.800999257830243 0.38983757532520213 LLLIGDSGVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLIGDSGVGK 11 0 E9PLD0;Q9H0U4;Q92928;A0A2R8YDI9;H0YLJ8;H0YL94;H0YMN7;H0YNE9;G3V196;A0A2R8YFB8;P51153;Q92930;P61006-2;P59190-2;P59190;P61026;E7END7;P62820-2;P62820;P62820-3;P61006 E9PLD0;P61026;E7END7;P61006 RAB1B;RAB1C;RAB8B;RAB15;RAB13;RAB8A;RAB10;RAB1A Ras-related protein Rab-1B;Putative Ras-related protein Rab-1C;Ras-related protein Rab-13;Ras-related protein Rab-8B;Ras-related protein Rab-8A;Ras-related protein Rab-15;Ras-related protein Rab-10;Ras-related protein Rab-1A 0 5606430.0 2037500.0 922530.0 2646400.0 False True 1972820.6777711108 1290901.0399303949 1953228.4497017665 1.0 0.6543428171022886 0.9900689260356499 20.911828395609792 -10.744992568386442 9.673577842406424 1.000606852540045 0.8222058717554751 0.2721668208302246 0.1370596100361294 0.0017996272266336138 4.744029584013072e-05 0.13313609972239887 0.04423579892563436 1.79890169753202e-11 10.744992568386442 -0.17840098078457 LLLIGDSGVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLIGDSGVGK 11 0 E9PLD0;Q9H0U4;Q92928;A0A2R8YDI9;H0YLJ8;H0YL94;H0YMN7;H0YNE9;G3V196;A0A2R8YFB8;P51153;Q92930;P61006-2;P59190-2;P59190;P61026;E7END7;P62820-2;P62820;P62820-3;P61006 E9PLD0;P61026;E7END7;P61006 RAB1B;RAB1C;RAB8B;RAB15;RAB13;RAB8A;RAB10;RAB1A Ras-related protein Rab-1B;Putative Ras-related protein Rab-1C;Ras-related protein Rab-13;Ras-related protein Rab-8B;Ras-related protein Rab-8A;Ras-related protein Rab-15;Ras-related protein Rab-10;Ras-related protein Rab-1A 0 10581100.0 3597100.0 2969900.0 4014100.0 False True 4927045.077972401 2838679.9978540405 3066052.2529845275 1.0 0.5761424855934597 0.6222902783439284 22.232291240379535 -10.482461802332592 9.447749613285312 1.0000051681923 0.5992163822579923 0.9901543106064028 0.01883975749905948 2.050928636833054e-06 1.1235306528455324e-07 0.018241751926751867 0.006080505586703645 3.292594115378987e-11 10.482461802332592 -0.40078878593430756 LLLIQAFRPDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLIQAFRPDR 11 1 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 15198800.0 5626000.0 6960600.0 2612200.0 False True 7375740.482261509 5922105.612206289 2341914.6019917466 1.0 0.8029167547921217 0.3175158626613828 22.81435646430766 -6.955780957487919 0.49129753633270257 1.0104987772381162 0.08930524870415804 0.9995803203134446 0.005875216984056418 0.0812440981301679 0.026972954912872972 0.007008367749984525 0.04003453559346343 1.1071820659781988e-07 6.955780957487919 -0.9211935285339582 down LLLIQAFRPDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLIQAFRPDR 11 1 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 10907300.0 3843200.0 3899400.0 3164700.0 False True 3721199.7196613243 5456450.755102369 2335770.131035059 1.0 1.466314943074051 0.6276927622814191 21.827336392422264 -6.755740127229765 1.6281646723886547 1.2722802154165334 0.6252192734853097 0.6735166410855371 0.1960328691868312 0.290110700956687 1.5146431796154973 0.09503816042701013 0.2293936202703155 1.754930301452937e-07 6.755740127229765 -0.6470609419312237 LLLIQAFRPDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLLIQAFRPDR 11 1 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 25836000.0 5526400.0 10889000.0 9420600.0 False True 8383952.833958188 8945772.873854687 7558614.280804335 1.0 1.067011355028253 0.9015573477690716 22.999199169977445 -6.796804896247051 1.4693665683221167 1.0371244939045008 0.8994609868541291 0.822520336836669 0.028626783186010533 0.22535804475508645 0.9609495760780132 0.015330625360778708 0.03571802227627462 1.5965962458252063e-07 6.796804896247051 -0.13766350705037167 LLLIQAFRPDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLIQAFRPDR 11 1 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 30092000.0 5626000.0 11582000.0 12884000.0 False True 7706084.236933298 11070268.94344776 9841064.554309208 1.0 1.4365621505135877 1.277051256089765 22.877566525830552 -10.038933229591077 4.987114793009853 0.9999942524508161 1.3568067033045283 0.8696475402521671 0.06512004996877217 4.161552973480882e-06 8.020265612862896e-07 0.06305323264137874 0.021017405751357066 9.142537922017772e-11 10.038933229591077 0.35681245085371227 LLLIQAFRPDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLLIQAFRPDR 11 1 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 11135400.0 3843200.0 4237400.0 3054800.0 False True 3195791.082627846 4214572.285141956 3693544.556200654 1.0 1.3187884239530399 1.1557528201009666 21.60774166785654 -10.237981595825218 3.845175553760031 0.9997233744653891 1.2372706221002723 0.7384924171283456 0.06655900680875665 8136046.577650654 5415699.802476842 17428.266281380886 0.022784918501296613 5.7812054600419725e-11 10.237981595825218 0.23754724763488322 LLLIQAFRPDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLLIQAFRPDR 11 1 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 17772900.0 5526400.0 5732700.0 6513800.0 False True 7154033.74163009 5413670.2055517 5328355.237232088 1.0 0.7567297556969813 0.7448043201454051 22.770325492069894 -13.999999999998156 0.4302748429465019 5.989763109551169 0.744567012631062 0.9998762543859748 0.0013080744004615836 31.803597433328747 0.22024704921179802 149.7061873302538 0.0028206791083680537 1.0000000000042456e-14 13.999999999998156 -5.2451960969201075 LLLIWQHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLIWQHK 8 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 0 4337600.0 1334400.0 1472600.0 1530600.0 False True 1749411.3223479837 1252893.8201498406 1372228.1945519384 1.0 0.7161802396867198 0.7843942570979783 20.738438105550262 -9.961377956350505 5.457105383956677 1.0000005365012943 0.7502872483917754 0.9469998605607586 0.027848255995836433 1.817915819200301e-07 3.4531554639212876e-08 0.026964016181324553 0.008987985974107262 1.093004735732122e-10 9.961377956350505 -0.24971328810951887 LLLK(ub)HGADPTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLKHGADPTK 11 1 E7EQ52;O95271 E7EQ52 TNKS Tankyrase-1 1 2311630.0 693020.0 781690.0 836920.0 True False 908555.9312152256 665064.8990037544 750323.5467035192 1.0 0.7320021543574171 0.8258418892273753 19.793215804749888 -10.858384332344452 10.352755563110387 1.0075584560666624 0.7789220217923962 0.8809582806095194 0.0383099113382426 0.00669500448404823 9.15810314488224e-05 0.037157402670885145 0.012364470717308026 1.385529151167326e-11 10.858384332344452 -0.22863643427426616 LLLK(ub)HGADPTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLKHGADPTK 11 1 E7EQ52;O95271 E7EQ52 TNKS Tankyrase-1 1 3484770.0 525670.0 1274800.0 1684300.0 True False 508982.8935872101 1783834.2879941775 1243131.3020830895 1.0 3.5047038131715365 2.4423832662071363 18.9572576439959 -10.510814426564554 6.553217510344826 0.998771126317505 2.973543539689336 0.8214836743749321 0.4336905472228523 0.007788679380141587 0.000581410731667737 0.4200353191840172 0.13997302223347405 3.0845056737352124e-11 10.510814426564554 1.9747724133718312 LLLK(ub)HGADPTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLKHGADPTK 11 1 E7EQ52;O95271 E7EQ52 TNKS Tankyrase-1 1 2111010.0 693020.0 538500.0 879490.0 True False 949248.222161305 514707.28941863356 671772.5756651199 1.0 0.5422262348268794 0.7076890532758523 19.85642586627278 -10.058411021003929 5.7211002125327255 1.0000015387051606 0.6249576440512935 0.8726135031041093 0.06754991276738195 1.3257276404382646e-06 2.182245855614671e-07 0.06540518978704776 0.021801640598782174 8.74156072835789e-11 10.058411021003929 -0.3750438946538671 LLLK(ub)HGADPTKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLKHGADPTKK 12 2 E7EQ52;O95271 E7EQ52 TNKS Tankyrase-1 1 2087050.0 500900.0 804880.0 781270.0 True False 484999.20367879776 1126272.781393751 576631.9494023953 1.0 2.3222157332440734 1.1889338065476154 18.88762285297453 -6.608613768988169 2.1584830596783946 1.8841904209367952 1.192912567068974 0.04615357508616624 0.5702500755971555 0.6165400842510129 5.441067364631829 0.21830065699686863 0.6333591128039594 2.4625566555538757e-07 6.608613768988169 -0.6912778538678213 LLLK(ub)QNVDVEAEDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLKQNVDVEAEDK 14 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 17268900.0 3237000.0 4152500.0 9879400.0 True False 3134243.2068442195 5810614.905001435 7291688.764352947 1.0 1.8539132165343284 2.326459142810025 21.579685701813165 -9.267827051861627 0.16879846817214744 2.7528319139135996e-20 2.966795597136043 0.9997164165231148 0.009244019762142132 0.7115523672307067 0.062024272971187906 0.6877467177893896 0.3272278167108236 5.397255134311859e-10 9.267827051861627 2.966795597136043 LLLK(ub)QNVDVEAEDK(ub)DGDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLKQNVDVEAEDKDGDR 18 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 17181500.0 3134600.0 3939900.0 10107000.0 True False 3035093.8387932894 5513122.6163070705 7459673.496499305 1.0 1.8164587024759045 2.457806543294611 21.53330969162683 -6.973836807819591 0.1386706592945382 0.12443725927988111 4.166539132735114 0.9999989683769012 0.0006059083847659907 0.07507610077895281 0.004194434212087791 0.036759914171886406 0.08403245131929775 1.0620945790069931e-07 6.973836807819591 4.042101873455232 LLLK(ub)QNVDVEAEDK(ub)DGDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLLKQNVDVEAEDKDGDR 18 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 12431400.0 3134600.0 4331600.0 4965200.0 True False 2606558.7863252577 4308264.811044718 6003400.363509072 1.0 1.6528554175133474 2.3031900891722077 21.313714967061106 -6.971173061162924 0.22843747544702422 0.7302876917001746 3.2443050793799064 0.9999901425163741 0.001670370656438238 0.07592387372454416 0.007654188887896962 0.016904209645376162 0.0647887228157841 1.0686289584920953e-07 6.971173061162924 2.514017387679732 LLLK(ub)QNVDVEAEDKDGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLKQNVDVEAEDKDGDR 18 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 141384700.0 23556200.0 51637700.0 66190800.0 True False 30882406.31856531 43933556.442178145 59342010.96298725 1.0 1.4226079402292882 1.921547509959194 24.88028183419469 -6.968930342707601 0.28256686947320947 0.8934234010001426 2.4659894222863525 0.9999727962166368 0.001964494947136477 0.07665132093821828 0.010266744691034332 0.009081853703574304 0.04564988948417134 1.0741616852977746e-07 6.968930342707601 1.5725660212862098 LLLK(ub)QNVDVEAEDKDGDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLKQNVDVEAEDKDGDR 18 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 237967600.0 49138400.0 54600200.0 134229000.0 True False 47578528.38900024 76402344.59628147 99070398.11631596 1.0 1.6058156311943659 2.08225015507668 25.503807313891254 -6.973825234616807 0.13919479751955652 0.3544595310896162 3.3460254861164955 0.9999989511945684 0.00045351987479784163 0.07507982128988908 0.00421226176762039 0.02715767293511639 0.06227490351810496 1.0621228823823089e-07 6.973825234616807 2.9915659550268794 LLLK(ub)QNVDVEAEDKDGDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLLKQNVDVEAEDKDGDR 18 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 325836000.0 56568000.0 178146000.0 91122000.0 True False 85817791.67475148 146354454.43894905 73111696.75980869 1.0 1.7054092348779013 0.8519410175095306 26.354773441307206 -6.687219003517178 1.8764127045994572 1.4434026419016084 0.854997133944737 0.3573554691471388 0.29851045933733916 0.4226933257729052 2.8833013250050676 0.12737377500718977 0.33284347302388306 2.054854124683579e-07 6.687219003517178 -0.5884055079568714 LLLK(ub)QNVDVEAEDKDGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLKQNVDVEAEDKDGDR 18 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 182840200.0 23556200.0 45309000.0 113975000.0 True False 32265563.722369008 43307098.563173346 87056452.38880713 1.0 1.3422080251196566 2.698122776898914 24.94349189571758 -6.94509246769459 0.6103497926079497 0.9850095110812669 3.125975573081035 0.9987576995886818 0.025845222519064678 0.08551826878243526 0.044593667363733755 0.026262379614225242 0.11434831434032376 1.1347691808698245e-07 6.94509246769459 2.140966061999768 up LLLK(ub)QNVDVEAEDKDGDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLLKQNVDVEAEDKDGDR 18 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 192616300.0 49138400.0 72816200.0 70661700.0 True False 40860756.80021854 72423924.67771596 85436734.76721357 1.0 1.772456761675266 2.090923944089959 25.28421258932553 -10.317164357711315 0.1978952225667248 3.9808975063322355e-16 2.3692605735663124 0.9994091187909333 0.011134116097628662 1.9581280735350624 0.09752820622044847 1.18990309784097 0.19714485228661702 4.8176544013863796e-11 10.317164357711315 2.369260573566312 LLLK(ub)QNVDVEAEDKDGDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLLKQNVDVEAEDKDGDR 18 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 268540400.0 56568000.0 166555000.0 45417400.0 True False 73228391.12198372 157286067.83638835 37151899.22187736 1.0 2.147883702297672 0.5073428304602485 26.125899763399655 -6.71858998307823 1.7642270214902462 1.6993978856961554 0.5100715501329302 0.5059340612149934 0.4831184850182232 0.35806143798161677 2.177226951639328 0.21749136759108612 0.546925645407139 1.911657200250675e-07 6.71858998307823 -1.189326335563225 LLLLAGVDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLLAGVDR 9 0 Q9Y570-2;Q9Y570;Q9Y570-4;Q9Y570-3 Q9Y570-2 PPME1 Protein phosphatase methylesterase 1 0 4680300.0 1200400.0 1920500.0 1559400.0 False True 1573736.024690135 1633968.8860503659 1398048.2468210447 1.0 1.0382738022230193 0.8883626128443729 20.585762135703884 -6.838982325016116 1.2869962359800782 1.0203654071359025 0.8835270553997825 0.9227024631870131 0.017681501099308192 0.16999650357441712 0.5473840836767555 0.010774177859396 0.02481687606750365 1.4488308170852082e-07 6.838982325016116 -0.13683835173612002 LLLLAGVDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLLAGVDR 9 0 Q9Y570-2;Q9Y570;Q9Y570-4;Q9Y570-3 Q9Y570-2 PPME1 Protein phosphatase methylesterase 1 0 2594230.0 1198100.0 597270.0 798860.0 False True 1160066.9713067843 835763.0257219025 589614.6007137062 1.0 0.7204437729835872 0.5082591051183202 20.145776664662527 -7.316173737777095 0.14363530602096378 1.295639291476085 5.256441792315826e-12 0.9999945314982297 0.0004708869724054402 0.11060939220347996 0.008719146008713128 0.025873144522354955 0.04874360154783795 4.8286559493914476e-08 7.316173737777095 -1.2956392914708286 LLLLAGVDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLLLAGVDR 9 0 Q9Y570-2;Q9Y570;Q9Y570-4;Q9Y570-3 Q9Y570-2 PPME1 Protein phosphatase methylesterase 1 0 10423600.0 1758400.0 6891000.0 1774200.0 False True 2667621.3562594275 5661247.210371252 1423528.5923405145 1.0 2.1222079352031895 0.53363217722046 21.347122473397754 -6.716901792113708 1.7702649159718231 1.6849892943371008 0.5364995799746186 0.49789873261674433 0.47241897890255935 0.3613973577106025 2.211627590618023 0.21202433388623362 0.53424971670754 1.9191026621586377e-07 6.716901792113708 -1.1484897143624822 LLLLAGVDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLLAGVDR 9 0 Q9Y570-2;Q9Y570;Q9Y570-4;Q9Y570-3 Q9Y570-2 PPME1 Protein phosphatase methylesterase 1 0 3749000.0 1200400.0 1132100.0 1416500.0 False True 1644220.3195902444 1082080.0786459344 1081951.8737332346 1.0 0.6581113648538288 0.6580333917797996 20.648972197226776 LLLLAGVDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLLLAGVDR 9 0 Q9Y570-2;Q9Y570;Q9Y570-4;Q9Y570-3 Q9Y570-2 PPME1 Protein phosphatase methylesterase 1 0 8421700.0 1758400.0 3525000.0 3138300.0 False True 2276283.4632459413 3328830.6512759672 2567161.601677281 1.0 1.46239723875563 1.1277864304371619 21.118248795490203 -10.573383685416312 10.287637489011685 0.9999879493556564 1.2950918345963884 0.5090787804067387 0.13660429046674602 3.7764507016602686e-05 1.5659265230502452e-06 0.13227192723724596 0.04408884516651566 2.6706459350374697e-11 10.573383685416312 0.29510388524073206 LLLLGAGESGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLLGAGESGK 11 0 P63092;P63092-4;Q5JWF2;P38405;P38405-2;Q5JWD1;Q5JWE9;A2A2R6;H0Y7E8;A0A1W2PS82;A0A1W2PRJ7;A0A1W2PRE1;A0A1W2PQK2;A8MTJ3;P19087;P11488;A0A087WZE5;A0A087WTB6;P63092-2;Q5JWF2-2;P63092-3;H0Y7F4;P04899-4;P04899;P63096;A0A3B3IUA8;P09471-2;P09471;P08754 P63092;P63092-2;P63092-3;P04899-4;P08754 GNAS;GNAL;GNAT3;GNAT2;GNAT1;GNAO1;GNAI2;GNAI1;GNAI3 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha;Guanine nucleotide-binding protein G(t) subunit alpha-3;Guanine nucleotide-binding protein G(t) subunit alpha-2;Guanine nucleotide-binding protein G(t) subunit alpha-1;Guanine nucleotide-binding protein G(i) subunit alpha-2;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(o) subunit alpha;Guanine nucleotide-binding protein G(k) subunit alpha 0 7882900.0 1941700.0 2070800.0 3870400.0 False True 2545587.5034495476 1761844.7119151803 3469928.1354983747 1.0 0.6921171279823182 1.3631148529745079 21.279567227785055 -6.78192943612221 1.528171418654407 0.8261059349562644 1.368772318464074 0.7742120330628717 0.1303123840703963 0.24759094924489197 1.1421399483301975 0.0671522048123829 0.15820947455315879 1.6522302296869938e-07 6.78192943612221 0.5426663835078097 LLLLGAGESGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLLGAGESGK 11 0 P63092;P63092-4;Q5JWF2;P38405;P38405-2;Q5JWD1;Q5JWE9;A2A2R6;H0Y7E8;A0A1W2PS82;A0A1W2PRJ7;A0A1W2PRE1;A0A1W2PQK2;A8MTJ3;P19087;P11488;A0A087WZE5;A0A087WTB6;P63092-2;Q5JWF2-2;P63092-3;H0Y7F4;P04899-4;P04899;P63096;A0A3B3IUA8;P09471-2;P09471;P08754 P63092;P63092-2;P63092-3;P04899-4;P08754 GNAS;GNAL;GNAT3;GNAT2;GNAT1;GNAO1;GNAI2;GNAI1;GNAI3 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha;Guanine nucleotide-binding protein G(t) subunit alpha-3;Guanine nucleotide-binding protein G(t) subunit alpha-2;Guanine nucleotide-binding protein G(t) subunit alpha-1;Guanine nucleotide-binding protein G(i) subunit alpha-2;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(o) subunit alpha;Guanine nucleotide-binding protein G(k) subunit alpha 0 7920800.0 1941700.0 3258400.0 2720700.0 False True 2659598.962469493 3114433.1139121195 2078126.6945753715 1.0 1.1710160659035238 0.7813684408440991 21.342777289307946 -6.7874256273574405 1.5068105107124614 1.0959020296096411 0.7775249123431067 0.79281086683751 0.07258687719462753 0.23921141458622594 1.0730246116738351 0.03792491302253258 0.08895299913697309 1.6314522704283718e-07 6.7874256273574405 -0.3183771172665344 LLLLGAGESGK(ub)STIVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLLLGAGESGKSTIVK 16 1 P63092;P63092-4;Q5JWF2;P38405;P38405-2;Q5JWD1;Q5JWE9;A2A2R6;H0Y7E8;A0A1W2PS82;A0A1W2PRJ7;A0A1W2PRE1;A0A1W2PQK2;A8MTJ3;P19087;P11488;A0A087WZE5;A0A087WTB6;P63092-2;Q5JWF2-2;P63092-3;H0Y7F4;P04899-4;P04899;P63096;A0A3B3IUA8;P09471-2;P09471;P08754 P63092;P63092-2;P63092-3;P04899-4;P08754 GNAS;GNAL;GNAT3;GNAT2;GNAT1;GNAO1;GNAI2;GNAI1;GNAI3 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha;Guanine nucleotide-binding protein G(t) subunit alpha-3;Guanine nucleotide-binding protein G(t) subunit alpha-2;Guanine nucleotide-binding protein G(t) subunit alpha-1;Guanine nucleotide-binding protein G(i) subunit alpha-2;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(o) subunit alpha;Guanine nucleotide-binding protein G(k) subunit alpha 1 71639500.0 6242500.0 24200000.0 41197000.0 True False 9470328.88788072 19881320.924536977 33054394.892713446 1.0 2.0993274003376285 3.4903111902495283 23.174983098151458 -6.967930300120321 0.3035790393437396 0.7687913301664412 4.864655826882705 0.9999614406501388 0.006327515517384475 0.076980148665457 0.011421206236841957 0.022677042690516153 0.12428631491555843 1.0766379892925597e-07 6.967930300120321 4.095864496716264 LLLLGAGESGK(ub)STIVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLLLGAGESGKSTIVK 16 1 P63092;P63092-4;Q5JWF2;P38405;P38405-2;Q5JWD1;Q5JWE9;A2A2R6;H0Y7E8;A0A1W2PS82;A0A1W2PRJ7;A0A1W2PRE1;A0A1W2PQK2;A8MTJ3;P19087;P11488;A0A087WZE5;A0A087WTB6;P63092-2;Q5JWF2-2;P63092-3;H0Y7F4;P04899-4;P04899;P63096;A0A3B3IUA8;P09471-2;P09471;P08754 P63092;P63092-2;P63092-3;P04899-4;P08754 GNAS;GNAL;GNAT3;GNAT2;GNAT1;GNAO1;GNAI2;GNAI1;GNAI3 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha;Guanine nucleotide-binding protein G(t) subunit alpha-3;Guanine nucleotide-binding protein G(t) subunit alpha-2;Guanine nucleotide-binding protein G(t) subunit alpha-1;Guanine nucleotide-binding protein G(i) subunit alpha-2;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(o) subunit alpha;Guanine nucleotide-binding protein G(k) subunit alpha 1 32533500.0 6242500.0 17540000.0 8751000.0 True False 8081039.308071413 16563883.581100838 7158407.792842582 1.0 2.0497219416513275 0.8858276169616823 22.946109420243907 -6.669086319824807 1.9403958117391742 1.6705450190695625 0.8905263608082978 0.2751190287175048 0.44599042396371735 0.4632051113191044 3.361383248606817 0.18508667604892562 0.49513408029652073 2.1424647252049837e-07 6.669086319824807 -0.7800186582612647 LLLLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLLLR 6 0 Q9HA65-3;Q9HA65;A0A087WXG5;M0QYC9;M0R2L2;Q9HA65-2 Q9HA65-3 TBC1D17 TBC1 domain family member 17 0 8685700.0 2792000.0 2981400.0 2912300.0 False True 3660339.037766458 2536586.7414061753 2610963.1327542183 1.0 0.692992292581182 0.7133118287172191 21.80354585320261 -10.405668206156323 5.8886376910087295 1.0000939138049099 0.7031520606492007 0.9964981505378488 0.00829541589055665 1.0231066931008855e-05 1.0326091224789892e-06 0.00803452992548822 0.0026773339661657343 3.929450242914273e-11 10.405668206156323 -0.2969418531557092 LLLLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLLLR 6 0 Q9HA65-3;Q9HA65;A0A087WXG5;M0QYC9;M0R2L2;Q9HA65-2 Q9HA65-3 TBC1D17 TBC1 domain family member 17 0 6065500.0 2595800.0 1796100.0 1673600.0 False True 2513397.749869085 2513292.0965377614 1235233.9530762092 1.0 0.9999579639429019 0.49145979904714593 21.2612075677836 -6.9069112898106955 0.9165163233417896 1.0173229927160483 0.4299090870313858 0.989702727720162 0.024325522130178332 0.10649597811317012 0.15011051699542646 0.01961635090105929 0.053058095041313875 1.2390496523846646e-07 6.9069112898106955 -0.5874139056846626 down LLLLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLLLLR 6 0 Q9HA65-3;Q9HA65;A0A087WXG5;M0QYC9;M0R2L2;Q9HA65-2 Q9HA65-3 TBC1D17 TBC1 domain family member 17 0 25019500.0 6970000.0 10756000.0 7293500.0 False True 10573999.575254882 8836507.762988435 5851936.528145381 1.0 0.8356826288954561 0.5534269683384513 23.33401783809167 -6.962907269908827 0.39231606629972765 1.0168939946794224 0.36203615219213997 0.9998632934221342 0.002156257740449701 0.0786784900021575 0.01741018548054516 0.0036399287300403114 0.02371983237076109 1.0891626253411312e-07 6.962907269908827 -0.6548578424872824 LLLLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLLLR 6 0 Q9HA65-3;Q9HA65;A0A087WXG5;M0QYC9;M0R2L2;Q9HA65-2 Q9HA65-3 TBC1D17 TBC1 domain family member 17 0 14362600.0 2792000.0 4359400.0 7211200.0 False True 3824277.8509629807 4166787.293392001 5508063.079325882 1.0 1.0895618612917402 1.4402884136514589 21.866755914725502 -6.945362982859107 0.6076315725231174 0.9961065715828279 1.5519341093238146 0.9987852357406188 0.006621996772804143 0.08540305962946353 0.04409376017504468 0.006746289781897308 0.029549705489909005 1.1340625711840023e-07 6.945362982859107 0.5558275377409867 LLLLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLLLLR 6 0 Q9HA65-3;Q9HA65;A0A087WXG5;M0QYC9;M0R2L2;Q9HA65-2 Q9HA65-3 TBC1D17 TBC1 domain family member 17 0 5767300.0 2595800.0 1426500.0 1745000.0 False True 2158522.713438115 1418815.1613619213 2109871.4320316063 1.0 0.6573084232697368 0.9774608434260965 21.041612843217877 -10.506236055652353 8.704503498716043 1.000009195330375 0.817384633793572 0.3025576370318881 0.13070167821670226 2.3324713367785747e-05 1.3231666593719518e-06 0.12655772372145876 0.04218378525455404 3.117194809010851e-11 10.506236055652353 -0.18262456153680295 LLLLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLLLLR 6 0 Q9HA65-3;Q9HA65;A0A087WXG5;M0QYC9;M0R2L2;Q9HA65-2 Q9HA65-3 TBC1D17 TBC1 domain family member 17 0 22315700.0 6970000.0 8613400.0 6732300.0 False True 9022802.399240326 8134056.718212882 5507090.479231409 1.0 0.9015000393777578 0.6103525529601621 23.105144160184118 -6.951783707875076 0.5389049934566605 1.0043175861974318 0.49411498366028994 0.9993339341385882 0.0042693725974075145 0.08277729161741769 0.03305846459645318 0.004702918170369066 0.024106972693323084 1.117419618859467e-07 6.951783707875076 -0.5102026025371419 LLLNNDNLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLNNDNLLR 10 0 P52907;P47755;F8W9N7;A0A0D9SET8;C9JUG7;P47755-2 P52907;P47755 CAPZA1;CAPZA2 F-actin-capping protein subunit alpha-1;F-actin-capping protein subunit alpha-2 0 14879000.0 1926900.0 9240400.0 3711700.0 False True 2526184.560126145 7861768.338797085 3327648.889140483 1.0 3.1121116259235264 1.3172627771006236 21.26852861393342 -6.606345471209403 2.1665068072246854 2.4144827610728745 1.323363746911733 0.03942100884173161 0.9114295129753134 0.6227669743137844 5.533375614612258 0.34799156772964496 1.0129150086336296 2.4754521093498504e-07 6.606345471209403 -1.0911190141611415 LLLNNDNLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLNNDNLLR 10 0 P52907;P47755;F8W9N7;A0A0D9SET8;C9JUG7;P47755-2 P52907;P47755 CAPZA1;CAPZA2 F-actin-capping protein subunit alpha-1;F-actin-capping protein subunit alpha-2 0 15233500.0 5904400.0 2234900.0 7094200.0 False True 5716968.053905156 3127307.224849537 5236016.198561927 1.0 0.5470219870676609 0.9158729153620686 22.446818797919896 -9.957172132903365 6.835342843601926 1.0000000199960066 0.7314474512148638 0.4141077089009261 0.15058276091220543 4.582097752691785e-08 6.992676693930389e-09 0.14580114217274093 0.048600377103241395 1.1036411043258833e-10 9.957172132903365 -0.26855256878114286 LLLNNDNLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLNNDNLLR 10 0 P52907;P47755;F8W9N7;A0A0D9SET8;C9JUG7;P47755-2 P52907;P47755 CAPZA1;CAPZA2 F-actin-capping protein subunit alpha-1;F-actin-capping protein subunit alpha-2 0 19701800.0 1926900.0 11460000.0 6314900.0 False True 2639327.002514533 10953659.306847803 4823450.6794479415 1.0 4.150171349140164 1.8275305314015868 21.33173867545631 -6.568020759680574 2.3153097028950134 3.16041118719296 1.8322112138078404 0.0 1.3726651651095207 0.735805081061543 7.4026314126760315 0.5017862465114798 1.5389870980061395 2.7038291154707125e-07 6.568020759680574 -1.3281999733851197 LLLNNGAK(ub)MPILGLGTWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLLNNGAKMPILGLGTWK 18 1 P15121;E9PCX2;E9PEF9 P15121 AKR1B1 Aldose reductase 1 9564400.0 2957600.0 5069100.0 1537700.0 True False 2459375.4438957423 5041791.752162429 1859225.9604785074 1.0 2.0500293132048366 0.7559748411301628 21.22986056033815 -6.6908137424390155 1.863060812964562 1.6577637835702637 0.7603395666585357 0.3745162049329579 0.44400971378004245 0.4148831596467261 2.792531989166537 0.19059077776946734 0.4958879555272789 2.0379158992184122e-07 6.6908137424390155 -0.8974242169117279 LLLPGELAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLPGELAK 9 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 569520000.0 41590000.0 270740000.0 257190000.0 False True 54524892.758132935 230346647.336254 230578445.94068503 1.0 4.224614404251084 4.228865647907065 25.70041169152668 LLLPGELAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLPGELAK 9 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 447880000.0 191580000.0 67800000.0 188500000.0 False True 185498397.76558998 94872893.57232909 139126195.1212148 1.0 0.5114485877781961 0.7500129208502672 27.466831484782603 -10.110179194584553 5.162726771549327 1.000009406787775 0.6307307543136806 0.7615971991862492 0.0973934811442477 1.0545405097360045e-05 1.8175757381516414e-06 0.09430323362768608 0.03143361087479331 7.759268947691346e-11 10.110179194584553 -0.3692786524740943 LLLPGELAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLLPGELAK 9 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 2311637000.0 50167000.0 2216600000.0 44870000.0 False True 76107006.69896868 1821030411.6251538 36001424.832780346 1.0 23.927237328200302 0.47303693042585787 26.18152594401823 -9.423976216465153 10.247621234734224 0.9999807162918375 12.20013712931302 0.2331578861261927 9.575137216594758 0.0 0.0 9.271086744377653 3.090362248125884 3.767244292097834e-10 9.423976216465153 11.200156413021183 LLLPGELAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLPGELAK 9 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 553260000.0 41590000.0 262460000.0 249210000.0 False True 56966946.927489445 250863649.36084443 190351730.64105865 1.0 4.403670248998195 3.3414416764048886 25.76362175304957 -9.922048912524367 7.584760347478266 0.9999999808456443 3.8725559627015427 0.9069835742670164 0.43365299884308994 1.4125205827686974e-07 1.9797826225645528e-08 0.41988272315147834 0.13996090354601554 1.1966057556960663e-10 9.922048912524367 2.872555981855898 LLLPGELAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLLPGELAK 9 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 214073000.0 191580000.0 11091000.0 11402000.0 False True 159307258.43303543 11031250.581608858 13786105.483108524 1.0 0.06924512222552513 0.0865378364972836 27.24723676021688 -10.765120609831738 2.9602265422743446 1.1859865301058627 0.07789147839205457 0.9997363002932552 0.007059724047369007 7962024.965561232 7086120.603506737 10806291.312277284 0.0026796137552828163 1.71743136550047e-11 10.765120609831738 -1.1080950517138082 LLLPGELAK(ub)HAVSEGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLPGELAKHAVSEGTK 17 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 932250800.0 294923300.0 439390000.0 197937500.0 True False 386647302.34129995 373834724.7288051 177456826.2505713 1.0 0.9668623638781141 0.45896305282876965 28.526442906422073 -6.920164302002739 0.8235098572274703 1.011140342807043 0.3767501136638839 0.9942263484139366 0.018814266875493032 0.09807533243393285 0.10511502065455185 0.016224497019615158 0.04867648502656581 1.2018096807538058e-07 6.920164302002739 -0.634390229143159 down LLLPGELAK(ub)HAVSEGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLPGELAKHAVSEGTK 17 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 1188191500.0 389954500.0 447710000.0 350527000.0 True False 377575607.84780174 626482937.7768064 258713463.11540648 1.0 1.6592251320147182 0.6851964420850305 28.492190325775148 -6.724435320201996 1.7433318119163415 1.3991684146751033 0.6863291848952335 0.5332655218528994 0.2772668786532271 0.3468256963835589 2.0622700366949505 0.1261682494412159 0.3150921047361344 1.8860998468177032e-07 6.724435320201996 -0.7128392297798698 LLLPGELAK(ub)HAVSEGTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLLPGELAKHAVSEGTK 17 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 2921838600.0 1244695000.0 1036486600.0 640657000.0 True False 1888293314.3933823 851517468.1232319 514030863.14006126 1.0 0.45094555047809587 0.2722198184052749 30.814435734339316 -13.999999999999998 0.1569434693293486 3.687287082775216 0.09046060228015675 0.9995447439254379 0.006607373818610882 11.99070397329405 0.12508236459268712 9.8119607673521 0.16504513235527551 1.0000000000000041e-14 13.999999999999998 -3.5968264804950594 LLLPGELAK(ub)HAVSEGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLPGELAKHAVSEGTK 17 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 941507000.0 294923300.0 373426700.0 273157000.0 True False 403964414.0125041 356927473.63703865 208642942.44500488 1.0 0.8835616733952969 0.5164884212760054 28.589652967944964 -6.950330848161789 0.5552000940515921 1.0049269561932113 0.3777240609098781 0.9992269875633847 0.00572863629059133 0.08335317078924077 0.03541473300527316 0.006176994967189346 0.030482912826036938 1.1211640193586237e-07 6.950330848161789 -0.6272028952833332 LLLPGELAK(ub)HAVSEGTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLLPGELAKHAVSEGTK 17 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 1293608500.0 389954500.0 704590000.0 199064000.0 True False 324264444.6634576 700794233.8198358 240687362.03205684 1.0 2.1611812375765247 0.7422564082900227 28.272595601209424 -6.689131860429419 1.869049143833712 1.7285470673087329 0.7471445513026859 0.36661536072618617 0.49117991394963634 0.41850911020328285 2.8337585340114604 0.21026576458940124 0.548237793906403 2.0458233898085654e-07 6.689131860429419 -0.981402516006047 LLLPGELAK(ub)HAVSEGTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLLPGELAKHAVSEGTK 17 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 2452394400.0 1244695000.0 995342400.0 212357000.0 True False 1611282214.1065192 939950720.4637115 173710204.96682325 1.0 0.5833557351000294 0.10780867773877106 30.585562056431765 -7.682167242996571 0.4740302269043058 1.0235312573441184 1.6535206656713948e-21 0.9965860983071791 0.021297230074290692 0.1170602515998399 0.08268117843726432 0.027996685210054138 0.07509027854123725 2.0788959683315268e-08 7.682167242996571 -1.0235312573441184 down LLLPLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLPLFR 7 0 Q9BV86;Q9BV86-2 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 0 10998000.0 3712500.0 3521800.0 3763700.0 False True 4867123.451901145 2996361.167868877 3374268.427959704 1.0 0.6156328676435091 0.6932777566267981 22.21463793756845 -10.082642538560103 5.161434210098621 1.0000063624422129 0.6544553121344373 0.9635131615071033 0.03169839319319616 2.3208381921126816e-06 4.1244080358214135e-07 0.030692402108492188 0.010230612411204135 8.267181292236983e-11 10.082642538560103 -0.34555105030777555 LLLPLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLPLFR 7 0 Q9BV86;Q9BV86-2 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 0 12222600.0 6276700.0 2829200.0 3116700.0 False True 6077449.594191876 3958914.3140830914 2300342.7710041935 1.0 0.6514104728843105 0.37850462358463577 22.535034592047783 -7.64605799264372 0.2034727283191504 1.2074132431513749 1.035467286838194e-14 0.9999175724596114 0.0023092334833954664 0.13239748265098458 0.023820822475426082 0.043028962199303654 0.07815433339006182 2.2591340811343746e-08 7.64605799264372 -1.2074132431513644 down LLLPLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLPLFR 7 0 Q9BV86;Q9BV86-2 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 0 21197800.0 3712500.0 11154000.0 6331300.0 False True 5085111.576540146 10661179.398654483 4835977.337216547 1.0 2.0965477823218643 0.9510071243130701 22.277847999091343 -6.656059500558359 1.9866430300127154 1.7080938477990164 0.9557821189204032 0.21912326760163392 0.467324510534527 0.4938284818713697 3.7423361174107703 0.19031679611540042 0.5179317042592491 2.2077022458341332e-07 6.656059500558359 -0.7523117288786132 LLLPLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLLPLFR 7 0 Q9BV86;Q9BV86-2 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 0 10174600.0 6276700.0 2202000.0 1695900.0 False True 5219354.154956856 2190137.3889372223 2050504.8490443514 1.0 0.419618466943316 0.39286562823045323 22.31543986748206 -13.648432293374892 0.4420901775172646 9.999999998651194 0.39267893507710144 0.9998850560792342 0.0030031412378778116 24.52439570414767 0.22467667277797584 212.47172178153647 0.006152726989031529 2.2468170280605478e-14 13.648432293374892 -9.607321063574092 LLLPWLEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLPWLEAR 9 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 8973000.0 2117700.0 3871400.0 2983900.0 False True 2776325.207835971 3293802.2105990094 2675154.6515899133 1.0 1.1863891885945128 0.9635595441195033 21.404745138772206 -6.684796305002075 1.8849860521491084 1.1174193453820054 0.9643758057194043 0.3461676198968988 0.07891468335360219 0.42794180981533936 2.9438381902553177 0.03354385872275099 0.08792526045953979 2.0663490980852316e-07 6.684796305002075 -0.1530435396626011 LLLPWLEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLPWLEAR 9 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 6146900.0 2118900.0 1974900.0 2053100.0 False True 2051636.6793272211 2763487.868967447 1515331.5183202457 1.0 1.3469674708066042 0.7385964257653834 20.968343838601747 -6.75197698470463 1.642262886508991 1.2035278504265305 0.7371813046344778 0.6575756612297207 0.1458150350036112 0.29659175317936703 1.5743745160709381 0.07011847812447068 0.16989461376838796 1.770202767153868e-07 6.75197698470463 -0.4663465457920527 LLLPWLEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLPWLEAR 9 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 15534000.0 2117700.0 7203900.0 6212400.0 False True 2900670.918690654 6885607.877888385 4745159.068394175 1.0 2.373798362827214 1.6358832840424766 21.467955200295098 -10.258465095543302 4.9177204835555415 0.9997733081630186 2.004840823435774 0.7120155820012468 0.3012525694245866 0.0007489057160116171 0.0001129260081101275 0.291750383798294 0.09722884869817663 5.514865238382074e-11 10.258465095543302 1.0050675152727555 LLLPWLEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLLPWLEAR 9 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 5225500.0 2118900.0 1484100.0 1622500.0 False True 1761959.2331859232 1476104.8587292158 1961757.2484076105 1.0 0.8377633437410275 1.1133953677579806 20.748749114036023 -6.747203543834313 1.660084967502836 0.9042811180439423 1.1138309234433086 0.6368328247426565 0.06816607080634039 0.3049802976985376 1.6527502805650347 0.032448429811174406 0.07901208368246421 1.7897668348876865e-07 6.747203543834313 0.2095498053993663 LLLPWLEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLLPWLEAR 9 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 3700900.0 576700.0 1295100.0 1829100.0 False True 746549.5184565127 1223026.5465156042 1496222.5681508791 1.0 1.6382390133265443 2.004183957206632 19.50987843159809 -9.425753889052373 0.13970149113966712 5.472626932650831e-21 2.662278438783478 0.999835187621831 0.005327092476182276 0.8807594822648659 0.054316817274919854 0.6746134714288978 0.3274209942105997 3.7518555644142774e-10 9.425753889052373 2.662278438783478 LLLQLYLDNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLLQLYLDNR 10 0 Q86X83;Q86X83-2;F8WBW1 Q86X83 COMMD2 COMM domain-containing protein 2 0 54311000.0 14892000.0 20155000.0 19264000.0 False True 22592252.751032423 16558182.778266234 15456461.956288869 1.0 0.7329141967708181 0.6841487711128116 24.429324798187398 -13.999999999999998 0.23916546161478883 2.7607310389755786 0.6624157989301853 0.9995235870821548 0.003030316806425298 13.594073193751331 0.15478772385958925 11.425987209904008 0.023945973574579373 1.0000000000000041e-14 13.999999999999998 -2.0983152400453933 LLLQLYLDNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLLQLYLDNR 10 0 Q86X83;Q86X83-2;F8WBW1 Q86X83 COMMD2 COMM domain-containing protein 2 0 34726300.0 14892000.0 8674300.0 11160000.0 False True 19277987.565206196 8191567.579677468 9128994.511269923 1.0 0.42491818982506185 0.47354499427867436 24.200451120279848 -10.159586513832057 8.153602361714526 1.000000077369857 0.4492315935754001 0.994187765430798 0.019851809788907902 2.7924436511406428e-08 2.880516036162389e-09 0.01922143475388359 0.006407144058709823 6.924899679138494e-11 10.159586513832057 -0.5507684837944569 LLLQLYLDNRK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLLQLYLDNRK 11 1 Q86X83;Q86X83-2;F8WBW1 Q86X83 COMMD2 COMM domain-containing protein 2 0 63413100.0 13240000.0 23579000.0 26594100.0 False True 20086047.973654922 19371143.226432133 21337764.47839189 1.0 0.9644078940685362 1.0623177096051315 24.259690399030465 -6.80832414047352 1.4213891185392868 0.9805640472176685 1.0639687307294763 0.8554638439685095 0.01538388460660808 0.20908546454150645 0.8328460227261011 0.008510768664760063 0.01970414741378359 1.5548047527767526e-07 6.80832414047352 0.08340468351180774 LLLQLYLDNRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLLQLYLDNRK 11 1 Q86X83;Q86X83-2;F8WBW1 Q86X83 COMMD2 COMM domain-containing protein 2 0 57056000.0 13240000.0 17504000.0 26312000.0 False True 17139440.9994178 16529887.012747366 21523485.983918834 1.0 0.9644355970132783 1.2557869293782657 24.030816721122914 -6.876363694458707 1.0998359156119564 0.9788574343521911 1.2750507513974223 0.9706339997995599 0.02223915727602513 0.13090192776428516 0.29214141181957337 0.01562340375586149 0.03745734780301469 1.329340712032177e-07 6.876363694458707 0.2961933170452312 LLLQVQHASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLQVQHASK 10 0 P05141;P12236;V9GYG0;P12235 P05141;P12236 SLC25A5;SLC25A6;SLC25A4 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed;ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed;ADP/ATP translocase 1 0 179077000.0 75616000.0 48208000.0 55253000.0 False True 99133308.26638557 41015554.31331223 49535949.584201045 1.0 0.4137414056948195 0.49969027010670086 26.562866540966805 -10.7307485533624 6.924805385136618 1.007421866289827 0.4567158379012822 0.981574855741686 0.03508847696346093 0.004019159676722924 0.00015627352481450423 0.03396239333021476 0.01132475724360556 1.858880393102581e-11 10.7307485533624 -0.550706028388545 LLLQVQHASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLQVQHASK 10 0 P05141;P12236;V9GYG0;P12235 P05141;P12236 SLC25A5;SLC25A6;SLC25A4 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed;ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed;ADP/ATP translocase 1 0 86905000.0 26104000.0 11655000.0 49146000.0 False True 25275342.808607157 16308902.28002209 36273188.251603305 1.0 0.6452494988304699 1.4351215145240677 24.591227323695854 -6.784577319754199 1.5176549547131584 0.800325907739489 1.4423435966889229 0.783371805663678 0.1503442109262529 0.24352729651654462 1.1080606306045213 0.07799675506890373 0.18337792768580694 1.6421872663226e-07 6.784577319754199 0.6420176889494339 LLLQVQHASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLLQVQHASK 10 0 P05141;P12236;V9GYG0;P12235 P05141;P12236 SLC25A5;SLC25A6;SLC25A4 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed;ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed;ADP/ATP translocase 1 0 152495000.0 36248000.0 59921000.0 56326000.0 False True 54990866.08376453 49227629.385090075 45193141.41143723 1.0 0.8951964733580366 0.8218299624995363 25.71268867284927 -6.97494879519266 0.07378562432124518 1.29018353824212 0.42500713827739306 0.9999999218156135 1.9611583813018703e-05 0.07472759088567509 0.0021335971668325045 0.009763012962450312 0.015167357889006607 1.059378622183314e-07 6.97494879519266 -0.8651763999647271 LLLQVQHASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLQVQHASK 10 0 P05141;P12236;V9GYG0;P12235 P05141;P12236 SLC25A5;SLC25A6;SLC25A4 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed;ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed;ADP/ATP translocase 1 0 167449000.0 75616000.0 41757000.0 50076000.0 False True 103573278.64556473 39912037.668066606 38249080.147592984 1.0 0.38535072163398915 0.3692948668592805 26.626076602489697 LLLQVQHASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLLQVQHASK 10 0 P05141;P12236;V9GYG0;P12235 P05141;P12236 SLC25A5;SLC25A6;SLC25A4 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed;ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed;ADP/ATP translocase 1 0 97182000.0 26104000.0 45108000.0 25970000.0 False True 21706632.603277773 44864994.250763066 31400206.928287 1.0 2.0668795142360454 1.4465719995438382 24.37163259913013 -10.5943948723019 6.388098804772339 0.9980596163724521 1.7567257568894301 0.6649101473494881 0.25323948243498157 0.007010597657754618 0.00044512942386995926 0.24562600508410545 0.08173269150607237 2.5445156579669438e-11 10.5943948723019 0.758666140516978 LLLQVQHASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLLQVQHASK 10 0 P05141;P12236;V9GYG0;P12235 P05141;P12236 SLC25A5;SLC25A6;SLC25A4 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed;ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed;ADP/ATP translocase 1 0 173709000.0 36248000.0 88830000.0 48631000.0 False True 46923750.554901466 83886532.41215427 39780656.996197864 1.0 1.7877201080507368 0.8477723226674714 25.48381499494172 -6.684419399941056 1.8861513924543782 1.496420581065343 0.8512187802094803 0.344388623603323 0.3335391562463588 0.4288312881706795 2.953247860983895 0.14169802533966172 0.3716210568766782 2.0681431698817484e-07 6.684419399941056 -0.6452018008558628 LLLSTLTLLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLSTLTLLSK 11 0 G3V5E4;G3V4W4;Q96EK6 G3V5E4 GNPNAT1 Glucosamine 6-phosphate N-acetyltransferase 0 3017440.0 899650.0 1651100.0 466690.0 False True 1179449.862222993 1404762.3159373906 418401.39560658764 1.0 1.1910318199450505 0.354742841563436 20.169682661017568 -6.846633287352788 1.251184719281949 1.1017212582682143 0.32341290353457 0.9352678053477184 0.0910349904411736 0.1611992630458141 0.4873008869862139 0.05697922183882598 0.1316039980446649 1.4235302903624131e-07 6.846633287352788 -0.7783083547336443 down LLLSTLTLLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLSTLTLLSK 11 0 G3V5E4;G3V4W4;Q96EK6 G3V5E4 GNPNAT1 Glucosamine 6-phosphate N-acetyltransferase 0 12487300.0 4481200.0 5023500.0 2982600.0 False True 4338946.7588848695 7029409.747206427 2201367.583917961 1.0 1.6200728282300978 0.5073506789199974 22.04891345297502 -6.7554875020943825 1.6296342862905173 1.362196368462109 0.5041946387988288 0.6721776295983309 0.2606618867011982 0.290580662791935 1.5198603290131671 0.12627320061470607 0.3048003839607406 1.755951425348696e-07 6.7554875020943825 -0.8580017296632803 LLLSTLTLLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLSTLTLLSK 11 0 G3V5E4;G3V4W4;Q96EK6 G3V5E4 GNPNAT1 Glucosamine 6-phosphate N-acetyltransferase 0 12192650.0 899650.0 3080100.0 8212900.0 False True 1232274.9171270947 2944010.9974713693 6273182.169984948 1.0 2.3890861986665994 5.0907326626514 20.23289272254046 -6.960587476805327 0.4270739699071761 0.8892959486555686 6.6936278338020045 0.9997913701109027 0.024532434694734432 0.07949193697357712 0.020360852092254595 0.03513479090688909 0.22447688583109995 1.0949959760103685e-07 6.960587476805327 5.804331885146436 LLLSTLTLLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLLSTLTLLSK 11 0 G3V5E4;G3V4W4;Q96EK6 G3V5E4 GNPNAT1 Glucosamine 6-phosphate N-acetyltransferase 0 7413700.0 4481200.0 1501100.0 1431400.0 False True 3726316.3508201255 1493013.2763549804 1730699.1219541754 1.0 0.4006673443134754 0.4644530842297556 21.829318728409298 -10.151818134474363 5.274000221803317 1.000019081320924 0.43256021427523583 0.9906120124585507 0.026040419277831926 5.842686034962209e-06 9.396607647127656e-07 0.025214373963902317 0.008404509182458787 7.049882286308141e-11 10.151818134474363 -0.5674588670456882 LLLTPWVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLTPWVK 8 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 6942300.0 1932700.0 2321600.0 2688000.0 False True 2533788.4162934255 1975226.3295259196 2409871.5451166932 1.0 0.779554566128847 0.951094230923194 21.27286462675127 -9.881146393429187 5.229417609844124 1.0000001898174544 0.8653243986116435 0.4511044873448379 0.07003077490703305 95382356.87138383 60.02836762443295 217.9903867116812 0.023973396958862626 1.3147815665419796e-10 9.881146393429187 -0.13467579120581097 LLLTPWVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLTPWVK 8 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 5941000.0 1932700.0 2114000.0 1894300.0 False True 2647271.4192536403 2020596.4899368472 1446905.354333122 1.0 0.7632751501191083 0.5465647926426282 21.336074688274163 -6.972180979534577 0.1993255116762978 1.1301191808031648 0.17374177069570346 0.9999947692559594 0.00042346933388821124 0.07560116927259922 0.006430605337761022 0.007075089145050224 0.023045862939625964 1.0661517410619788e-07 6.972180979534577 -0.9563774101074614 LLLTPWVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLLTPWVK 8 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 3348590.0 1377500.0 1245700.0 725390.0 False True 1145452.2835969657 1238989.16684791 877065.6951755906 1.0 1.0816593450381176 0.7656937855337075 20.12748593049679 -6.838095840950491 1.2912062879483122 1.0434567080087602 0.7556865320515436 0.9211368978965332 0.03760711088857103 0.17102900705729135 0.5547120539496516 0.022845327794930145 0.05260750890702005 1.4517911981299108e-07 6.838095840950491 -0.28777017595721666 LLLVAWDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLLVAWDR 8 0 Q9Y2E6-2;Q9Y2E6 Q9Y2E6-2 DTX4 E3 ubiquitin-protein ligase DTX4 0 59183500.0 21693700.0 14836000.0 22653800.0 False True 28440650.782089632 12622526.630275046 20309802.086593933 1.0 0.4438198945230896 0.7141117213599042 24.761451141452675 -10.46049927612568 6.204751108833146 1.0001891688621252 0.5789658079415033 0.7638863441416097 0.11034617623248413 0.00028888502410674444 2.5118352210618603e-05 0.10688944419258979 0.03561407523883997 3.463384618785888e-11 10.46049927612568 -0.42122336092062185 LLLVAWDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLLVAWDR 8 0 Q9Y2E6-2;Q9Y2E6 Q9Y2E6-2 DTX4 E3 ubiquitin-protein ligase DTX4 0 85891200.0 46580000.0 23356200.0 15955000.0 False True 45101343.39660291 32682452.460973926 11775906.860259853 1.0 0.7246447666442595 0.2610988049004951 25.42666707070222 -7.083649010813691 0.4149753128896137 1.0233636308436758 8.3352905702578e-18 0.9998031533768993 0.004277790590165527 0.07501481957637636 0.020408402810450883 0.006609735745299146 0.03710137096203725 8.248044382080238e-08 7.083649010813691 -1.0233636308436758 down LLLVAWDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLVAWDR 8 0 Q9Y2E6-2;Q9Y2E6 Q9Y2E6-2 DTX4 E3 ubiquitin-protein ligase DTX4 0 59942700.0 21693700.0 17833000.0 20416000.0 False True 29714447.140199017 17045079.094155047 15594161.280718496 1.0 0.5736293532143734 0.5248006536060376 24.824661202975566 -13.999999999999998 0.3058536541621627 5.023018906097468 0.5134996248540363 0.9996628461567719 0.003919036204129347 16.979928957594606 0.17582131227771186 43.37313738690305 0.01721379748287927 1.0000000000000041e-14 13.999999999999998 -4.509519281243431 LLLYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLLYLR 6 0 Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5;Q9BXP5-5;H7C3A1;Q58EX7-2;Q58EX7 Q9BXP5-4;Q58EX7-2 SRRT;PLEKHG4 Serrate RNA effector molecule homolog;Puratrophin-1 0 28651000.0 8115600.0 12260000.0 8275400.0 False True 12311958.529833375 10072107.212182786 6639763.562763331 1.0 0.818075141154581 0.5392938537499437 23.553556941592596 -6.964899659775625 0.3597703627205468 1.0240856870464494 0.32373320901755465 0.9999110611149202 0.0017867665799637972 0.0779950358908547 0.014980115256823015 0.003742012064575816 0.023814711201934527 1.0841773754925958e-07 6.964899659775625 -0.7003524780288948 LLLYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLLYLR 6 0 Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5;Q9BXP5-5;H7C3A1;Q58EX7-2;Q58EX7 Q9BXP5-4;Q58EX7-2 SRRT;PLEKHG4 Serrate RNA effector molecule homolog;Puratrophin-1 0 9359100.0 2197400.0 2534800.0 4626900.0 False True 3009838.16250217 2422804.1545373313 3534121.5139966835 1.0 0.8049616038236357 1.1741898810461824 21.52125448540133 -6.763194032149084 1.6004837119159936 0.8871601708112987 1.1757537970626744 0.7038390161676717 0.08207556951844379 0.2775933648897247 1.4021266207128549 0.04044852095327214 0.09689868413794998 1.7250670020645422e-07 6.763194032149084 0.28859362625137563 LLLYLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLLYLR 6 0 Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5;Q9BXP5-5;H7C3A1;Q58EX7-2;Q58EX7 Q9BXP5-4;Q58EX7-2 SRRT;PLEKHG4 Serrate RNA effector molecule homolog;Puratrophin-1 0 35154600.0 8115600.0 14009000.0 13030000.0 False True 10505804.18239238 13229386.835099276 10658673.699090257 1.0 1.25924551851743 1.014550958122186 23.324683263685046 -10.695321215507061 4.092826606590448 0.9922482381148846 1.1368982383199733 0.29445098615303156 0.09989613596771406 0.007427447550490008 0.0005529147335723674 0.1016716425547657 0.032241339246043464 2.016874079298583e-11 10.695321215507061 0.14465000020508867 LLMAEEK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLMAEEKK 8 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 3810800.0 1078100.0 1451600.0 1281100.0 True False 1043876.3056221029 2031231.4499939964 945541.477823811 1.0 1.9458545414377182 0.9057983907971847 19.99351933885832 -6.667338975707707 1.9469946228249226 1.6051111542128667 0.9100626406494645 0.26727637347379785 0.402026265461653 0.46722876450951256 3.412089942151059 0.16639249539647455 0.44607675400697777 2.1511021002187975e-07 6.667338975707707 -0.6950485135634021 LLMAEEK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLMAEEKK 8 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 2860360.0 1078100.0 1313300.0 468960.0 True False 896487.917928048 1306224.9922303609 567017.367773949 1.0 1.4570469563597603 0.632487461832651 19.773924614292596 -6.756243965344521 1.6265740133410251 1.2667140588465087 0.6300180778298797 0.6754623881083586 0.1921456908296421 0.28927344704181923 1.5075011133367675 0.09324438638876405 0.22492299567344554 1.7528955344555688e-07 6.756243965344521 -0.6366959810166289 LLMHGK(ub)EVGSIIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLMHGKEVGSIIGK 14 1 Q15365;F8VTZ0;H3BSP4;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 1 13724600.0 5189700.0 5131200.0 3403700.0 True False 6803746.957126293 4365644.961260943 3051517.7745958674 1.0 0.6416530462950764 0.44850547702978366 22.697898055050985 -11.260541044038561 0.10508165987883804 2.0645846290026175 5.055532153921367e-13 0.9998649963769856 0.002654830840696285 3.8448348224037234 0.06672074069485809 1.269296963789754 0.3031128013198369 5.488566821426177e-12 11.260541044038561 -2.064584629002112 LLMHGK(ub)EVGSIIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLMHGKEVGSIIGK 14 1 Q15365;F8VTZ0;H3BSP4;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 1 26085100.0 7127600.0 8717500.0 10240000.0 True False 6901338.239450994 12198443.211161945 7557836.806584836 1.0 1.7675475086020909 1.0951262703487008 22.718444711536574 -10.245491515664416 4.330304963267477 0.9997706878286782 1.43133688948423 0.3542729933319869 0.2745148210305871 0.0006181289219674274 0.00010770187537551755 0.2659400013911322 0.08859927750559064 5.6820949193792755e-11 10.245491515664416 0.4315662016555518 LLMHGK(ub)EVGSIIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLMHGKEVGSIIGK 14 1 Q15365;F8VTZ0;H3BSP4;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 1 18264200.0 5189700.0 4510700.0 8563800.0 True False 7108472.336369128 4311402.359109804 6541206.8169973 1.0 0.6065160213188627 0.9201986738459228 22.761108116573876 -9.884373552513265 6.374621385638258 1.0000000182977131 0.7633573475823665 0.4314398172073268 0.1280604066424362 3.327296818987591e-08 5.7969064475721816e-09 0.12399396479689573 0.04133131851954493 1.3050478859797733e-10 9.884373552513265 -0.23664267071534661 LLMHGK(ub)EVGSIIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLMHGKEVGSIIGK 14 1 Q15365;F8VTZ0;H3BSP4;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 1 18842600.0 7127600.0 7324100.0 4390900.0 True False 5926915.206218318 7284643.619579983 5309016.888772243 1.0 1.2290784271617692 0.8957470630256702 22.49884998697085 -6.721752852196425 1.7528946149831817 1.1391065214626699 0.8962109443880881 0.5208135835087072 0.09637695512724576 0.351930307998694 2.11422410811405 0.043639218996705476 0.1093302592211228 1.8977856036153832e-07 6.721752852196425 -0.24289557707458176 LLMHGK(ub)EVGSIIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLMHGKEVGSIIGK 14 1 Q15365;F8VTZ0;H3BSP4;Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366 Q15365;Q15366-3;Q15366-4;Q15366-6 PCBP1;PCBP2;PCBP3 Poly(rC)-binding protein 1;Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 1 24623800.0 3005000.0 5131800.0 16487000.0 True False 3890031.737405624 4846210.818785247 13486535.170905659 1.0 1.2458023856682792 3.4669473365017387 21.89135049502688 -6.927903270884149 0.7638075469265486 0.9634661947693077 3.8995074077738026 0.9961098787081195 0.06920300606302628 0.09374115786727573 0.08312178432930349 0.062278215298542786 0.20334151386776755 1.1805835542282588e-07 6.927903270884149 2.936041213004495 up LLMLGLDNAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLMLGLDNAGK 11 0 P36404;V9GYD0;P36404-2 P36404 ARL2;ARL2-SNX15 ADP-ribosylation factor-like protein 2 0 3036280.0 889180.0 1127700.0 1019400.0 False True 1165723.59083137 959451.5557401724 913922.2667752808 1.0 0.8230523627439943 0.7839956864246783 20.152794315486485 -13.99999999999971 0.2123099510456301 2.0331924752160355 0.761499938666288 0.9994914307377155 0.002119428116472555 12.801750177572426 0.14602828633792908 5.523606495007384 0.022766415300989277 1.0000000000006667e-14 13.99999999999971 -1.2716925365497476 LLMLGLDNAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLMLGLDNAGK 11 0 P36404;V9GYD0;P36404-2 P36404 ARL2;ARL2-SNX15 ADP-ribosylation factor-like protein 2 0 4140880.0 889180.0 1135600.0 2116100.0 False True 1217933.875185985 1085425.4370729811 1616320.762447509 1.0 0.8912022722967871 1.3271005884458944 20.216004377009376 -6.840617736138868 1.2795431361884568 0.9421267832862269 1.3416121678789021 0.9255095545860765 0.05055861344544171 0.1680771412300504 0.5342779934875989 0.030980398676496174 0.07138425069240112 1.4433852531436874e-07 6.840617736138868 0.39948538459267524 LLMMAGIDDCYTSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLMMAGIDDCYTSAR 15 0 P15880;H0YEN5;E9PQD7;I3L404;E9PM36 P15880 RPS2 40S ribosomal protein S2 0 6753400.0 1946800.0 3518100.0 1288500.0 False True 2552273.65283802 2993213.193446392 1155178.3801647525 1.0 1.172763426099731 0.452607571637251 21.2833515913841 -6.843386469119588 1.2666836530260832 1.0919020391211627 0.4273046757201536 0.9301029378978772 0.08115855943041078 0.164882852857541 0.512442406327738 0.050211846727278686 0.11579798038320588 1.434212591040577e-07 6.843386469119588 -0.6645973634010091 down LLMMAGIDDCYTSAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLMMAGIDDCYTSAR 15 0 P15880;H0YEN5;E9PQD7;I3L404;E9PM36 P15880 RPS2 40S ribosomal protein S2 0 45443300.0 7026900.0 29673000.0 8743400.0 False True 10660321.035202099 24377621.31379279 7015263.157631635 1.0 2.2867623998652533 0.6580724102460053 23.345747549674478 -6.6960678572170895 1.8447050892213466 1.8020512862969607 0.6632193606272715 0.3991264196632389 0.5435528878663378 0.40370349568486635 2.6679313305763004 0.2353115109450019 0.6081559618869272 2.0134096360356243e-07 6.6960678572170895 -1.138831925669689 LLMMAGIDDCYTSAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLMMAGIDDCYTSAR 15 0 P15880;H0YEN5;E9PQD7;I3L404;E9PM36 P15880 RPS2 40S ribosomal protein S2 0 9042300.0 1946800.0 2569800.0 4525700.0 False True 2666584.570291813 2456257.738807806 3456822.869717265 1.0 0.9211250099369658 1.2963484857106833 21.346561652906992 -6.851803368004065 1.2262919097794192 0.9578341604205253 1.3118839267339422 0.9428970367742601 0.038600303591365556 0.15548431369513002 0.44902423829046495 0.024618472620953378 0.05704042719793873 1.4066842730190913e-07 6.851803368004065 0.3540497663134169 LLMMAGIDDCYTSAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLMMAGIDDCYTSAR 15 0 P15880;H0YEN5;E9PQD7;I3L404;E9PM36 P15880 RPS2 40S ribosomal protein S2 0 29397100.0 7026900.0 15326000.0 7044200.0 False True 9096460.570907021 14473094.627363235 5762227.879595673 1.0 1.5910688024804027 0.6334582373747499 23.116873871766927 -6.739685436337467 1.6875189255634029 1.3517956088127674 0.6328945673007617 0.6037285165980051 0.24834353845846247 0.31835550683736086 1.7799108180281396 0.11642032772868892 0.2858200715781771 1.8210193628562663e-07 6.739685436337467 -0.7189010415120057 LLMPSQLVSQVGK(ub)ELLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLMPSQLVSQVGKELLR 17 1 Q9NX09 Q9NX09 DDIT4 DNA damage-inducible transcript 4 protein 1 2966440400.0 6953400.0 940827000.0 2018660000.0 True False 10548816.161632331 772929071.1350981 1619670966.1898925 1.0 73.27164103459876 153.54054344798286 23.330577766122765 -7.481174134989549 0.4159433218629666 1.6545249899503173e-20 187.55748167429297 0.9966310259364839 3.616240929168174 0.17705949293633144 0.07468355719530956 5.094478868492045 17.950643005692303 3.302371024102553e-08 7.481174134989549 187.55748167429297 LLMPSQLVSQVGK(ub)ELLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLMPSQLVSQVGKELLR 17 1 Q9NX09 Q9NX09 DDIT4 DNA damage-inducible transcript 4 protein 1 1506950400.0 6953400.0 425562000.0 1074435000.0 True False 9001313.372005412 401879100.600937 878898854.6340779 1.0 44.64671809458423 97.64117949359506 23.101704088215214 -7.3701283606713295 0.4106271514964881 7.526953647999005e-18 122.63451732237074 0.9976383302121292 1.9203143968328138 0.16941495568109644 0.060989002087414486 2.6509553080941224 10.677172693476068 4.2645345700573026e-08 7.3701283606713295 122.63451732237074 LLNFLMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LLNFLMK 7 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 12901000.0 3908700.0 3671500.0 5320800.0 False True 5124343.551904648 3123726.5113949124 4770254.656717594 1.0 0.6095856922461544 0.9309006331053967 22.288935771001803 -9.97908732971787 6.759050648301045 1.000000028898014 0.7702431626757745 0.4053749925963208 0.13117627530628687 5.718177710242443e-08 8.540342589062688e-09 0.12701089850684755 0.04233696080656343 1.0493314035683828e-10 9.97908732971787 -0.22975686622223945 LLNFLMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LLNFLMK 7 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 14146600.0 3908700.0 4104800.0 6133100.0 False True 5353852.018645783 3923436.3632416087 4684588.095159413 1.0 0.7328249547386655 0.87499394433101 22.352145832524695 -10.128520955448595 4.677204175309683 1.000016457777689 0.8039094495322485 0.7172380297420893 0.058040246966918674 9.96153681064512e-06 1.8560550864970311e-06 0.056201942246713404 0.018732409158132082 7.438391705344932e-11 10.128520955448595 -0.19610700824544058 LLNILGLIFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLNILGLIFK 10 0 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 0 193381000.0 107800000.0 40068000.0 45513000.0 False True 104377948.0067366 56067361.351859614 33591779.93926715 1.0 0.5371571526606462 0.32182832275165174 26.63724170413122 -11.426710023771244 0.13696989194901757 2.1433691716861523 1.2506646881005236e-15 0.999702561087269 0.004879736653445536 4.104485372348954 0.0866594977692488 1.6471140434128655 0.23207052628543975 3.743604634303686e-12 11.426710023771244 -2.143369171686151 LLNILGLIFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLNILGLIFK 10 0 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 0 5323500000.0 1670200000.0 1900600000.0 1752700000.0 False True 2533815507.975712 1561423080.5444224 1406278076.7642994 1.0 0.6162339269096421 0.5550041320442417 31.23866433686344 -13.999999999755273 0.2583254541779418 3.7849950594885615 0.5322634855982337 0.9995589352527608 0.004135912404735626 14.343581808344268 0.16083130769014342 20.832236626030404 0.027006775674445933 1.0000000005635045e-14 13.999999999755273 -3.252731573890328 LLNILGLIFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLNILGLIFK 10 0 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 0 297151000.0 107800000.0 70971000.0 118380000.0 False True 89640476.34972972 70588665.13635945 143132710.6727227 1.0 0.7874641904061266 1.5967419685979198 26.417646979565497 -6.836923838854654 1.296734255700026 0.8868563172539523 1.621757876012018 0.9190110992028141 0.09749114903456328 0.17242482905432632 0.5645481822093389 0.05898287552844539 0.13578405872152385 1.4557143432101227e-07 6.836923838854654 0.7349015587580656 LLNILGLIFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLNILGLIFK 10 0 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 0 3925400000.0 1670200000.0 1196600000.0 1058600000.0 False True 2162106824.5640173 1130008158.1040637 865945662.1532567 1.0 0.5226421494377026 0.4005101192573462 31.00979065895589 -13.999999999999966 0.19140194655239406 3.571440658029286 0.314116668608434 0.9994886978036106 0.0058489603299000026 12.373883804549441 0.13873970484604842 11.872583277924095 0.08306490423099665 1.0000000000000778e-14 13.999999999999966 -3.2573239894208523 LLNILMQLR ddPTM_RPMI8226_Bortezomib_8h_R1 2 LLNILMQLR 9 0 O60264;A0A0A0MRP6;B7ZLQ5;P28370-2;P28370 O60264 SMARCA5;SMARCA1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Probable global transcription activator SNF2L1 0 206301100.0 51115000.0 57865000.0 97321100.0 False True 77545192.00705211 47538538.648691505 78085541.9276465 1.0 0.6130430194094852 1.0069681937281845 26.20853399759905 -10.91557814524309 11.261323583162167 1.0212832997491719 0.8100056065688348 0.2367373767351335 0.16081927898628817 0.07329130512776492 0.0005494361352285655 0.13280292427466295 0.0519041991052482 1.214568056203013e-11 10.91557814524309 -0.21127769318033707 LLNILMQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLNILMQLR 9 0 O60264;A0A0A0MRP6;B7ZLQ5;P28370-2;P28370 O60264 SMARCA5;SMARCA1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Probable global transcription activator SNF2L1 0 10256100.0 3196500.0 3011700.0 4047900.0 False True 2658031.3789602183 2995475.374324358 4894297.174625055 1.0 1.1269526003474581 1.8413240766704682 21.34192670554213 -6.937208281263009 0.6850463180202158 0.9914634551158272 2.0191103960025107 0.9977748623229115 0.01746876536882068 0.08906364787905288 0.06058517654995486 0.016664285631787533 0.062278370039891943 1.1555579206522075e-07 6.937208281263009 1.0276469408866835 LLNILMQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LLNILMQLR 9 0 O60264;A0A0A0MRP6;B7ZLQ5;P28370-2;P28370 O60264 SMARCA5;SMARCA1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Probable global transcription activator SNF2L1 0 156635000.0 51115000.0 52198000.0 53322000.0 False True 66169375.12728396 49293135.41427028 43617943.1299225 1.0 0.7449539204420413 0.6591862632225053 25.9796603196915 -13.999999998806032 0.15221087066386185 2.2376422752484633 0.5671819190723595 0.9995590272249679 0.0030395340992224354 11.96672317949884 0.12298024766096856 4.377818287644076 0.083110638695771 1.000000002749212e-14 13.999999998806032 -1.6704603561761038 LLNIQQQLTCSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLNIQQQLTCSLR 13 0 Q5M775-4;Q5M775;Q5M775-5;Q5M775-3;Q5M775-2 Q5M775-4 SPECC1 Cytospin-B 0 3735580.0 1145900.0 653780.0 1935900.0 False True 1569570.1967831235 624893.8378386527 1478680.2911120164 1.0 0.39813054498574796 0.9420924875756507 20.581938122160246 -10.52591146534453 9.127859627103819 1.0000155222101752 0.6701115162807022 0.3290318396563364 0.2220715331397298 7.015175922212148e-05 3.6435608816748163e-06 0.2150299331514629 0.07167327912641014 2.979123687448017e-11 10.52591146534453 -0.329904005929473 LLNLK(ub)NDSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLNLKNDSLR 10 1 E9PGT1;Q15631 E9PGT1 TSN Translin 1 12010100.0 3657200.0 4765600.0 3587300.0 True False 4794624.616375176 4054591.0561633026 3216120.607811424 1.0 0.8456534933549495 0.6707763099591454 22.192986436643984 -6.969501117432928 0.2698431195812285 1.0435559801607281 0.4676176496569466 0.9999782211907109 0.0006276180840489855 0.07646498761859866 0.009608311322875453 0.0034312829132869724 0.01626804992521812 1.0727508876606761e-07 6.969501117432928 -0.5759383305037815 LLNLK(ub)NDSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLNLKNDSLR 10 1 E9PGT1;Q15631 E9PGT1 TSN Translin 1 10527600.0 4202600.0 3317600.0 3007400.0 True False 4069190.7633869336 4642334.981055449 2219671.7199339066 1.0 1.1408496801932841 0.5454823450170211 21.956310484766817 -6.844339089384342 1.2622698068621239 1.0749365633448011 0.5241796164859854 0.9316291577459929 0.06642936640620087 0.16379660590156864 0.5051006918981639 0.041235930427756556 0.09512997622956171 1.4310701089419224e-07 6.844339089384342 -0.5507569468588157 LLNLK(ub)NDSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLNLKNDSLR 10 1 E9PGT1;Q15631 E9PGT1 TSN Translin 1 15047200.0 3657200.0 5802200.0 5587800.0 True False 5009365.672113829 5545839.618690435 4268076.724353383 1.0 1.107094187506225 0.8520193980074048 22.256196498166876 -6.792679670228768 1.4858766486565675 1.059647127460671 0.8491129685017239 0.8098093217110867 0.0456077198294381 0.23138132820324647 1.0091615586571443 0.024157660658699478 0.05644406392090886 1.6118340639760612e-07 6.792679670228768 -0.210534158958947 LLNLK(ub)NDSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLNLKNDSLR 10 1 E9PGT1;Q15631 E9PGT1 TSN Translin 1 10825000.0 4202600.0 4416600.0 2205800.0 True False 3494648.1067474424 4392806.899173544 2667022.5815331293 1.0 1.2570097946891827 0.7631734297893 21.736715760201093 -6.765269761912262 1.5925561364982823 1.1483025450948008 0.7608784432187832 0.7121446139106418 0.10819706845004673 0.2741473329548374 1.3714194287937118 0.05357564731106081 0.1280938916539167 1.716841640118058e-07 6.765269761912262 -0.3874241018760176 LLNLK(ub)NDSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLNLKNDSLR 10 1 E9PGT1;Q15631 E9PGT1 TSN Translin 1 20338100.0 5712000.0 5609300.0 9016800.0 True False 7394296.6003530575 5297137.524029018 7375834.9201808795 1.0 0.716381531649149 0.9975032540388904 22.817981483457434 -10.882059402301858 9.731098004570446 1.0101816799569059 0.85694239284402 0.2566605060818292 0.11476746257786861 0.02581840774868086 0.0003129177195697604 0.11317012472653727 0.03704103927088067 1.3120204300938734e-11 10.882059402301858 -0.15323928711288592 LLNLMWLPKPPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLNLMWLPKPPGR 13 1 Q8N531-2;Q8N531 Q8N531-2 FBXL6 F-box/LRR-repeat protein 6 0 5844010.0 265110.0 2058900.0 3520000.0 False True 363128.33132836584 1967930.990128179 2688648.4966756003 1.0 5.419381580416096 7.40412758993552 18.470119968255506 -8.794390799611445 0.36868861396217495 4.7998912802191106e-20 7.93830347609832 0.9976954118966557 0.12849848915562523 0.33381082774890225 0.12392747280929316 1.0487226705221504 0.536045224753493 1.6054958983536002e-09 8.794390799611445 7.93830347609832 LLNLYIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLNLYIK 7 0 E7ERI8;E7EW49;O75122-3;E3W994;J3KR49;A0A0U1RQI6;O75122;H7C5M8;F8WA11;Q7Z460-2;Q7Z460-4;Q7Z460-5;Q7Z460-3;Q7Z460;H0Y5T1 E7ERI8;F8WA11 CLASP2;CLASP1 CLIP-associating protein 2;CLIP-associating protein 1 0 11277300.0 2652900.0 3759700.0 4864700.0 False True 3477977.5907201427 3198767.4151958125 4361347.509497456 1.0 0.9197205363630542 1.2539895372340237 21.72981720643645 -6.843317685087666 1.2670709245164824 0.9572963120953718 1.265713627202345 0.9299798495565609 0.0377006748952447 0.1649633708226933 0.5130477864779054 0.02331854885776043 0.05377358629025823 1.4344397611783286e-07 6.843317685087666 0.30841731510697323 LLNLYIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLNLYIK 7 0 E7ERI8;E7EW49;O75122-3;E3W994;J3KR49;A0A0U1RQI6;O75122;H7C5M8;F8WA11;Q7Z460-2;Q7Z460-4;Q7Z460-5;Q7Z460-3;Q7Z460;H0Y5T1 E7ERI8;F8WA11 CLASP2;CLASP1 CLIP-associating protein 2;CLIP-associating protein 1 0 5747400.0 3183700.0 1467400.0 1096300.0 False True 3082635.1861692723 2053340.4723899108 809146.1417049755 1.0 0.6660990835381838 0.26248520919223167 21.5557327334217 -7.303563387897699 0.3516050180306559 1.0492962073678924 1.8847481412812632e-11 0.999710548711803 0.005130129640008265 0.10354154988117281 0.02659104179547212 0.012213475740473385 0.05073575173550147 4.970918148831615e-08 7.303563387897699 -1.0492962073490448 down LLNLYIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLNLYIK 7 0 E7ERI8;E7EW49;O75122-3;E3W994;J3KR49;A0A0U1RQI6;O75122;H7C5M8;F8WA11;Q7Z460-2;Q7Z460-4;Q7Z460-5;Q7Z460-3;Q7Z460;H0Y5T1 E7ERI8;F8WA11 CLASP2;CLASP1 CLIP-associating protein 2;CLIP-associating protein 1 0 43061000.0 11018000.0 18938000.0 13105000.0 False True 16715111.523695605 15558365.936730636 10514791.005874444 1.0 0.9307964182395584 0.6290589800115011 23.994649644900974 -6.942899794452038 0.632015807839072 1.003292056978729 0.5402451968341412 0.9985195218758938 0.0061966878176941634 0.08646842775641089 0.048770840337257364 0.0061738424400316905 0.025656673895937756 1.140512909802378e-07 6.942899794452038 -0.46304686014458774 LLNLYIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLNLYIK 7 0 E7ERI8;E7EW49;O75122-3;E3W994;J3KR49;A0A0U1RQI6;O75122;H7C5M8;F8WA11;Q7Z460-2;Q7Z460-4;Q7Z460-5;Q7Z460-3;Q7Z460;H0Y5T1 E7ERI8;F8WA11 CLASP2;CLASP1 CLIP-associating protein 2;CLIP-associating protein 1 0 19035100.0 2652900.0 6384600.0 9997600.0 False True 3633748.8219268243 6102507.260951175 7636372.787035225 1.0 1.679397107507082 2.1015136602055993 21.793027267959342 -8.830897980550587 0.13504147064765576 1.0077677217518311e-15 2.966054872468815 0.9999042603485027 0.0044398997059101695 0.3502453845135871 0.04062617411931607 0.4817378145945227 0.3448702844392502 1.4760532299494742e-09 8.830897980550587 2.9660548724688143 LLNLYIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLNLYIK 7 0 E7ERI8;E7EW49;O75122-3;E3W994;J3KR49;A0A0U1RQI6;O75122;H7C5M8;F8WA11;Q7Z460-2;Q7Z460-4;Q7Z460-5;Q7Z460-3;Q7Z460;H0Y5T1 E7ERI8;F8WA11 CLASP2;CLASP1 CLIP-associating protein 2;CLIP-associating protein 1 0 6516500.0 3183700.0 1865400.0 1467400.0 False True 2647387.6118240696 1855350.71994709 1774226.5555089847 1.0 0.7008232234903976 0.6701801230710336 21.336138008855976 -13.999999999999998 0.3220036478510553 4.104372824809712 0.6642316357528532 0.999698010882308 0.002585516371336643 18.170564891254454 0.18106236141263204 38.04169450149695 0.010123107661686313 1.0000000000000041e-14 13.999999999999998 -3.4401411890568587 LLNLYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLNLYIK 7 0 E7ERI8;E7EW49;O75122-3;E3W994;J3KR49;A0A0U1RQI6;O75122;H7C5M8;F8WA11;Q7Z460-2;Q7Z460-4;Q7Z460-5;Q7Z460-3;Q7Z460;H0Y5T1 E7ERI8;F8WA11 CLASP2;CLASP1 CLIP-associating protein 2;CLIP-associating protein 1 0 39606000.0 11018000.0 17748000.0 10840000.0 False True 14263018.197249638 16760308.19825412 8867231.227792647 1.0 1.1750884677049658 0.6216938873079844 23.765775966993424 -6.821647164359376 1.3649234369914962 1.0942148400199474 0.6091986951960314 0.8880935870728789 0.07725641701011356 0.19134734996509564 0.7000465906521031 0.04447581285187914 0.10245762150945999 1.5078315824741208e-07 6.821647164359376 -0.485016144823916 LLNNAFEELVAFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLNNAFEELVAFQR 14 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 16716100.0 8564500.0 4309400.0 3842200.0 False True 8292624.635470273 6030165.893224114 2835812.556470727 1.0 0.7271721750712214 0.34196803558924244 22.983397359740984 -6.966243662376201 0.3360244099339065 1.0437526863157556 0.012662814644954171 0.9999365332917484 0.002150520535532232 0.07754143120897199 0.013385616841826865 0.005506397362891722 0.03344017505480228 1.0808273793267044e-07 6.966243662376201 -1.0310898716708015 down LLNNAFEELVAFQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLNNAFEELVAFQR 14 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 8379600.0 1047300.0 3725700.0 3606600.0 False True 1434515.1122183139 3561086.25475767 2754795.3602585876 1.0 2.482432024888784 1.9203669147818256 20.452131735902398 -10.5540842727968 7.180454931304381 0.9992452388340248 2.201399469835303 0.858990601816383 0.22946212033054875 0.0027738269002237008 0.0001722584649354042 0.222280579281459 0.07405858088547149 2.7920020138411835e-11 10.5540842727968 1.2021542310012783 LLNNAFEELVAFQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLNNAFEELVAFQR 14 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 13956000.0 8564500.0 2312900.0 3078600.0 False True 7121761.221681448 2300439.948625297 3722321.026161891 1.0 0.3230155964260429 0.5226686082692128 22.76380263517526 -10.328420266018055 6.181649966626456 1.000040721503329 0.4228421023477231 0.9176435307616476 0.08150800077093646 4.5746772410129827e-05 4.970050756174888e-06 0.07892532350619931 0.026306594130708044 4.6943961283290316e-11 10.328420266018055 -0.5771986191556058 LLNNWLTYSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLNNWLTYSK 10 0 Q96QC0 Q96QC0 PPP1R10 Serine/threonine-protein phosphatase 1 regulatory subunit 10 0 10279800.0 2344300.0 3966600.0 3968900.0 False True 3211051.062325404 3791342.4962078924 3031527.5620613 1.0 1.18071697479088 0.9440919821019305 21.61461417639281 -6.702549729907101 1.8214196395546738 1.1119324183353823 0.9447521558680982 0.4298824665682647 0.07624736512219682 0.39022493513926954 2.518531576318766 0.033371489287982864 0.08556495090304371 1.9835825090694368e-07 6.702549729907101 -0.167180262467284 LLNNWLTYSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLNNWLTYSK 10 0 Q96QC0 Q96QC0 PPP1R10 Serine/threonine-protein phosphatase 1 regulatory subunit 10 0 6489400.0 3597200.0 1235400.0 1656800.0 False True 2991231.182980038 1228744.6549922999 2003229.2198223283 1.0 0.41078224310571443 0.6697005671847119 21.51230798551527 -10.381097755644147 5.949637703114262 1.0000955621097563 0.5402414051452257 0.8078437570705598 0.10570296317502047 0.00013401532568109895 1.394073182498415e-05 0.10236754959825713 0.03411548466846898 4.1581700342359185e-11 10.381097755644147 -0.4598541569645306 LLNQK(ub)LGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLNQKLGK 8 1 O43290 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 1 961270.0 0.0 0.0 961270.0 True False 0.0 0.0 709484.5495181436 0.0 LLNQKPLSLK(ub)LQEEGMER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLNQKPLSLKLQEEGMER 18 2 Q6UWE0;Q6UWE0-2;Q6UWE0-3 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 1 15165400.0 6990800.0 5293100.0 2881500.0 True False 9165006.499003507 4503390.112342204 2583350.021299756 1.0 0.49136791259579016 0.2818710517641901 23.127704473120083 -12.714230331722408 0.137811629702715 2.7219956952051483 4.869750213976454e-15 0.9996432152934982 0.005695595861283993 7.418349538852558 0.10358891913964167 3.748106712178551 0.23180126365302936 1.930943953073906e-13 12.714230331722408 -2.7219956952051434 LLNQKPLSLK(ub)LQEEGMER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLNQKPLSLKLQEEGMER 18 2 Q6UWE0;Q6UWE0-2;Q6UWE0-3 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 1 25590300.0 7247200.0 9065600.0 9277500.0 True False 7017141.602916709 12685541.356479459 6847444.430965894 1.0 1.807793268872706 0.9758167667757652 22.742452044998384 -10.395358507201914 3.706420359122865 0.9977519097885624 1.3918050178887693 0.2282185478593165 0.33965298490065265 41108893.2111952 30701998.5641989 692939.9822346171 0.11627225176586349 4.023847312720275e-11 10.395358507201914 0.3940531081002069 LLNQKPLSLK(ub)LQEEGMER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLNQKPLSLKLQEEGMER 18 2 Q6UWE0;Q6UWE0-2;Q6UWE0-3 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 1 16143000.0 6990800.0 4203800.0 4948400.0 True False 9575487.67926649 4018062.2158923885 3779689.835497025 1.0 0.41961959019513706 0.3947255703415578 23.190914534642975 LLNQKPLSLK(ub)LQEEGMER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLNQKPLSLKLQEEGMER 18 2 Q6UWE0;Q6UWE0-2;Q6UWE0-3 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 1 16160000.0 7247200.0 6726600.0 2186200.0 True False 6026367.905396669 6690362.470674434 2643324.312153291 1.0 1.1101815514255529 0.4386264419379655 22.52285732043266 -6.864799611170772 1.161329313866533 1.0607232043208064 0.4030085676806613 0.9592073364574517 0.05939282003343443 0.14193428672394978 0.3610710903546072 0.03980495382027162 0.09347299802234026 1.36521291735793e-07 6.864799611170772 -0.6577146366401451 down LLNQKPLSLK(ub)LQEEGMER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLNQKPLSLKLQEEGMER 18 2 Q6UWE0;Q6UWE0-2;Q6UWE0-3 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 1 18348400.0 4796500.0 3925900.0 9626000.0 True False 6209163.803150115 3707420.2138565397 7874166.771100742 1.0 0.5970884858884932 1.268152527576405 22.56596756107474 -6.744127454378416 1.6716565580806177 0.7614181147785446 1.268904084859989 0.6232666836148346 0.16927967728972707 0.3104133783428048 1.704709205892445 0.08006200933948204 0.19557650431109855 1.8024886786731627e-07 6.744127454378416 0.5074859700814445 LLPAELPAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLPAELPAKR 10 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 13072300.0 2445200.0 5879200.0 4747900.0 True False 3205680.8793504843 5002046.276942103 4256632.853072741 1.0 1.560369377115163 1.3278404848380274 21.612199383870443 -10.212931280680898 4.903426113326667 0.999938604591259 1.4441049309773095 0.8294557302606731 0.09492952275815214 6.372574391080122e-05 1.022885468162575e-05 0.09192777788415595 0.030638371725113914 6.12447292867033e-11 10.212931280680898 0.44416632638605047 LLPAELPAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLPAELPAKR 10 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 8887800.0 2545700.0 2603100.0 3739000.0 True False 2464888.1469457294 3642531.404987172 2759643.7324043615 1.0 1.4777674230372984 1.1195817286167191 21.23309075000119 -10.820164337302373 11.498823264372039 0.9974455361941897 1.2986745758270088 0.4810810812871319 0.1462286974158131 0.009614035272855417 0.00015035830773796566 0.14214642944567446 0.0471951091524206 1.51298862426486e-11 10.820164337302373 0.3012290396328191 LLPAELPAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLPAELPAKR 10 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 35330500.0 6001100.0 7276400.0 22053000.0 True False 9104107.439176774 5977869.56922731 17694214.883826733 1.0 0.6566123707529368 1.9435419674074834 23.118086152567628 -6.835704167413062 1.3020982443813873 0.8171037687978797 1.9824203019496247 0.9168307407559242 0.15691258577904005 0.17387489775042955 0.5744771794632351 0.09455282794574131 0.217655893024513 1.459808313468376e-07 6.835704167413062 1.165316533151745 LLPAELPAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLPAELPAKR 10 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 9539000.0 2445200.0 2896200.0 4197600.0 True False 3349256.5190453758 2768236.3075473476 3206213.3322856505 1.0 0.8265226302631385 0.9572910626742629 21.675409445393335 -10.39622421178827 5.1755829814184064 1.0000810779883953 0.8919068464835197 0.4767200197399305 0.05338598897849823 4.998273521413731e-05 5.83088636387418e-06 0.05172948614474353 0.01723025385287551 4.015834331600621e-11 10.39622421178827 -0.1081742315048756 LLPAELPAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLPAELPAKR 10 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 9822000.0 2545700.0 4135000.0 3141300.0 True False 2116862.343631792 4112723.934266758 3798131.306269848 1.0 1.9428395741646427 1.794226874362359 21.013496025435465 -10.163580294494425 4.630681012643474 0.9998838396571412 1.8685332242731758 0.9785134328461991 0.06067088066951418 7.285803336407093e-05 1.3160118685202097e-05 0.058752101380445884 0.019581442531260516 6.861510077190929e-11 10.163580294494425 0.8686493846160346 LLPAELPAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLPAELPAKR 10 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 32870000.0 6001100.0 6496900.0 20372000.0 True False 7768542.249366019 6135341.803765914 16664505.034371957 1.0 0.7897674501630743 2.1451263955901028 22.889212474660077 -6.867283291663955 1.1482965585364628 0.8828341562293702 2.2205343593691507 0.9618997019272929 0.11625431151629124 0.13949032695220337 0.34545360247462437 0.07869013942328108 0.1854825640818082 1.357427703348391e-07 6.867283291663955 1.3377002031397804 up LLPAITILGCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLPAITILGCR 11 0 Q96IJ6;Q96IJ6-2 Q96IJ6 GMPPA Mannose-1-phosphate guanyltransferase alpha 0 10392900.0 6467300.0 2217400.0 1708200.0 False True 6261999.101521038 3102819.3835882396 1260771.1750984571 1.0 0.4954998129646115 0.20133685020686382 22.5781918708012 -8.637487628900404 0.2586502458917356 1.2439970575504364 1.2469532929261293e-23 0.9992039674241703 0.009305004747301381 0.23111049389501725 0.07397071633652821 0.1562631899978818 0.10910961467287351 2.3041586102530435e-09 8.637487628900404 -1.2439970575504364 LLPAITILGCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLPAITILGCR 11 0 Q96IJ6;Q96IJ6-2 Q96IJ6 GMPPA Mannose-1-phosphate guanyltransferase alpha 0 16535200.0 3672000.0 5129100.0 7734100.0 False True 5570692.45915867 4213772.031158793 6205451.745023555 1.0 0.7564179968741606 1.1139462087556617 22.40942524074969 -6.723287622533397 1.7475747544225024 0.8523276113654666 1.1134904904546927 0.5279113979002907 0.10246133335906256 0.34898577775481704 2.084661312868999 0.04652301094061641 0.1163370326025639 1.8910907810053783e-07 6.723287622533397 0.2611628790892261 LLPAITILGCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLPAITILGCR 11 0 Q96IJ6;Q96IJ6-2 Q96IJ6 GMPPA Mannose-1-phosphate guanyltransferase alpha 0 10951620.0 6467300.0 520420.0 3963900.0 False True 5377846.499968528 517616.3941647185 4792733.162997181 1.0 0.09624975241813757 0.8911993235629222 22.358597146235475 -10.753159058908365 11.347696997579591 1.0008004055368327 0.493724537990611 0.3509847444759693 0.32453680342483937 0.006579315188468019 0.0001431164950684328 0.3145905765360003 0.10474380290798281 1.765391133643651e-11 10.753159058908365 -0.5070758675462217 LLPAITILGCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLPAITILGCR 11 0 Q96IJ6;Q96IJ6-2 Q96IJ6 GMPPA Mannose-1-phosphate guanyltransferase alpha 0 16209800.0 3672000.0 6083600.0 6454200.0 False True 4753476.385941246 5745042.312085804 5279601.825684442 1.0 1.208598054484332 1.1106822453771414 22.18055156284214 -10.238538979709563 4.357896205577986 0.9999233058443485 1.159640149934053 0.779938917844087 0.039973961688850417 2.9801499243241547e-05 5.2073287593139315e-06 0.038723193906887665 0.012901540656972901 5.7737904825251334e-11 10.238538979709563 0.15971684408970444 LLPCLHSACSACLGPAAPAAANSSGDGGAAGDGTVVDCPVCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLPCLHSACSACLGPAAPAAANSSGDGGAAGDGTVVDCPVCK 42 0 Q13263 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 9243400.0 1705300.0 2969700.0 4568400.0 False True 2335795.4939997075 2838488.8345153495 3489438.009151363 1.0 1.2152129078966811 1.4938970548214439 21.15548253673222 -6.9675850168312765 0.31050151094976763 0.9573198690027032 1.7606550768094076 0.9999569463697554 0.00132664190448629 0.07709437963602774 0.011821032945820424 0.004399386197665628 0.024729841325622955 1.077494304391203e-07 6.9675850168312765 0.8033352078067044 LLPEYPGVLSDVQEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLPEYPGVLSDVQEEK 16 0 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 0 11184900.0 3813900.0 1361900.0 6009100.0 False True 3692829.832123314 1905713.7722146746 4435136.440864148 1.0 0.5160578360901406 1.201012947383503 21.81629535312193 -6.716893780060576 1.770671475468825 0.7046039350754159 1.199752501909438 0.49777942558708466 0.20372543059304998 0.36136667260748007 2.212530351710495 0.09142039947603178 0.23032658538467826 1.9191380669242237e-07 6.716893780060576 0.4951485668340221 LLPEYPGVLSDVQEEK(ub)GIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLPEYPGVLSDVQEEKGIK 19 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 43453000.0 10538000.0 20657000.0 12258000.0 True False 13815420.050137172 17575056.120355353 10989659.74703883 1.0 1.2721333160030015 0.7954633089082018 23.719776091366437 -6.751872326281965 1.6430994307669922 1.1596572250887853 0.7943893618895457 0.6569232402366505 0.1143638089845311 0.2967860628888177 1.5770584753410664 0.05497212802300946 0.13318653456524807 1.7706294107382427e-07 6.751872326281965 -0.36526786319923965 LLPEYPGVLSDVQEEK(ub)GIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLPEYPGVLSDVQEEKGIK 19 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 85125000.0 14656000.0 18008000.0 52461000.0 True False 14190753.302288797 25198688.310479406 38719890.303735085 1.0 1.775711815553524 2.7285295909900733 23.758447839700935 -6.968364924327035 0.2946354099824973 0.8238521095457467 3.71001927370565 0.999966671486131 0.0040810065155976955 0.07683690174881923 0.010919203046453753 0.01624369500348254 0.08595281982909296 1.0755610728556898e-07 6.968364924327035 2.8861671641599034 LLPEYPGVLSDVQEEK(ub)GIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLPEYPGVLSDVQEEKGIK 19 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 740721000.0 38767000.0 74560000.0 627394000.0 True False 58812373.247332335 61254185.46006111 503389300.90344125 1.0 1.0415186818334956 8.55924141653771 25.8096163727538 -6.9081113355709185 0.9084956089426502 0.7531056752018136 9.49254706670375 0.9901892249244599 0.35199318018246295 0.10568034614120929 0.14563813730612812 0.285517078978837 0.7782189456323825 1.2356306270327414e-07 6.9081113355709185 8.739441391501936 up LLPEYPGVLSDVQEEK(ub)GIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLPEYPGVLSDVQEEKGIK 19 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 44945000.0 10538000.0 15139000.0 19268000.0 True False 14434183.378742097 14470108.922021724 14717295.236916322 1.0 1.0024889210797014 1.0196139851313777 23.78298615288933 -6.933010429288125 0.7216447065621611 0.999766424802768 1.0234154049041637 0.9970971923278432 0.000469718305840855 0.09110465427308241 0.07023942762954245 0.00043587225259749497 0.001524687343278749 1.1667815972539492e-07 6.933010429288125 0.02364898010139571 LLPEYPGVLSDVQEEK(ub)GIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLPEYPGVLSDVQEEKGIK 19 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 68729000.0 14656000.0 22118000.0 31955000.0 True False 12187113.370887192 21998845.943920717 38636642.75677359 1.0 1.8050907769900606 3.1702866446675992 23.53885311513521 -6.96313984750684 0.3886642807062391 0.9148966859352797 4.109428243582317 0.9998695061174556 0.01023304186098384 0.0785980648011744 0.017122336463088902 0.01764017840711094 0.11490342889387575 1.0885795025498042e-07 6.96313984750684 3.1945315576470374 LLPEYPGVLSDVQEEK(ub)GIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLPEYPGVLSDVQEEKGIK 19 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 948218000.0 38767000.0 54999000.0 854452000.0 True False 50184645.711814925 51938257.30199338 698950503.417886 1.0 1.0349431896012289 13.927576722003893 25.58074269484625 -6.907492807025513 0.9126369681185835 0.5684808122720156 15.507391979963101 0.9899405879102015 0.6103950664763693 0.10609944902485906 0.14793248463967773 0.49362451841251065 1.3400833109663766 1.2373916839859975e-07 6.907492807025513 14.938911167691085 up LLPGIEVLWTGPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLPGIEVLWTGPK 13 0 O60502-2;O60502-4;O60502;O60502-3 O60502-2 MGEA5 Protein O-GlcNAcase 0 2257970.0 592710.0 1098700.0 566560.0 False True 777048.5498118047 934778.2426990565 507937.8060272745 1.0 1.2029856344567567 0.6536757660126813 19.567645215134867 -6.80664360504775 1.428424054101218 1.1110718980103254 0.64477025940878 0.850933893514513 0.08755979584201912 0.21140749967047806 0.8507402761564061 0.048206163931596754 0.11169866420863968 1.560832843206963e-07 6.80664360504775 -0.4663016386015454 LLPGIEVLWTGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLPGIEVLWTGPK 13 0 O60502-2;O60502-4;O60502;O60502-3 O60502-2 MGEA5 Protein O-GlcNAcase 0 3128550.0 1210300.0 1007200.0 911050.0 False True 1171879.6889847254 1409380.2124786132 672418.6740858499 1.0 1.20266630245947 0.5737949726463895 20.160393032416515 -6.819972196258334 1.3720160689329512 1.1092414616302577 0.5600777443958339 0.8843015922221398 0.0891472944318625 0.19352778072305651 0.7158449188084076 0.051059364967489924 0.11768323639346426 1.5136581504573157e-07 6.819972196258334 -0.5491637172344238 LLPGIEVLWTGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLPGIEVLWTGPK 13 0 O60502-2;O60502-4;O60502;O60502-3 O60502-2 MGEA5 Protein O-GlcNAcase 0 4075210.0 592710.0 1381600.0 2100900.0 False True 811850.9043854834 1320556.3436597653 1604710.6893936833 1.0 1.6265995843896213 1.9766076267517885 19.63085527665776 -9.60191364238161 0.14150852812192602 1.6802845814584158e-19 2.579951187241295 0.9998108567874059 0.005556090182639714 1.0762120958183579 0.058514871893719525 0.7373788882237393 0.31667532653499325 2.500842594216718e-10 9.60191364238161 2.579951187241295 LLPGIEVLWTGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLPGIEVLWTGPK 13 0 O60502-2;O60502-4;O60502;O60502-3 O60502-2 MGEA5 Protein O-GlcNAcase 0 2656080.0 1210300.0 636960.0 808820.0 False True 1006418.0753810571 633528.5700533394 977940.5224388546 1.0 0.6294884656294237 0.9717040525813091 19.94079830785079 -10.449234382004233 8.602565617862094 1.0000036453221635 0.8005962600314709 0.31162429067796205 0.13970892834319468 9.767856331608467e-06 6.252950581934742e-07 0.13527505980680135 0.04509086273247319 3.554394416365948e-11 10.449234382004233 -0.19940738529069257 LLPHK(ub)VFEGNRPTNSIVFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLPHKVFEGNRPTNSIVFTK 20 2 P06744;A0A2U3TZU2;P06744-2;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 1 43954000.0 12480000.0 13730000.0 17744000.0 True False 18933072.410212502 11279774.227020372 14236890.622528533 1.0 0.5957709336671665 0.7519588112307198 24.174405211085496 -10.220540758519983 4.9989465035349205 1.0000413925212008 0.6738648724486392 0.8532330047754589 0.06376343400755663 2.9419139965850464e-05 4.587115849921425e-06 0.06174650132220151 0.020579559833870678 6.018097804250399e-11 10.220540758519983 -0.3261765200725616 LLPHK(ub)VFEGNRPTNSIVFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLPHKVFEGNRPTNSIVFTK 20 2 P06744;A0A2U3TZU2;P06744-2;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 1 17524000.0 6114800.0 5745000.0 5664200.0 True False 8375606.806256607 5491166.903825531 4326432.617860772 1.0 0.6556142176735912 0.5165515428242061 22.997762285711985 -13.999999999641064 0.12491363104639949 2.6372592364008955 0.30861225587334506 0.9996692123006504 0.003695959537113783 11.947547604048287 0.10937359097038557 4.827168076458363 0.18464962679614427 1.0000000008264807e-14 13.999999999641064 -2.3286469805275507 LLPHK(ub)VFEGNRPTNSIVFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLPHKVFEGNRPTNSIVFTK 20 2 P06744;A0A2U3TZU2;P06744-2;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 1 50278000.0 12480000.0 13742000.0 24056000.0 True False 16155606.017578114 12977245.61981115 19678054.835404057 1.0 0.8032657893298 1.2180326020573504 23.945531533177945 -6.777735542261042 1.5448234215720178 0.8882758360001857 1.221080287335905 0.7592482958008522 0.08311967494979539 0.2541107508171516 1.1976744173812104 0.04238624150545743 0.1001993033067078 1.668262769319081e-07 6.777735542261042 0.33280445133571934 LLPPLLQIVCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLPPLLQIVCK 11 0 Q8TEX9;Q8TEX9-2;H0YN14 Q8TEX9 IPO4 Importin-4 0 8189200.0 2569900.0 3038200.0 2581100.0 False True 3369163.786946998 2584912.4028108413 2314032.531659483 1.0 0.7672266966733564 0.6868269630062619 21.68395913398822 -13.999999995226482 0.14829964740838206 2.1227132736919576 0.5966184059750663 0.9995720128013295 0.0027473606820899157 11.951737042068855 0.12119154541280354 3.8687360462354152 0.08117875924181457 1.0000000109914325e-14 13.999999995226482 -1.5260948677168913 LLPPLLQIVCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLPPLLQIVCK 11 0 Q8TEX9;Q8TEX9-2;H0YN14 Q8TEX9 IPO4 Importin-4 0 14093600.0 2569900.0 4389800.0 7133900.0 False True 3520061.478936161 4195844.120872643 5449019.7472824035 1.0 1.1919803520422372 1.5479899370761034 21.747169195511113 -6.961495657322563 0.4138153497213332 0.9831757513379697 1.770088880412666 0.9998217108007454 0.0030314403999455296 0.07917110566117248 0.01918866354258352 0.00459030440476358 0.0296884809930765 1.0927085535470692e-07 6.961495657322563 0.7869131290746962 LLPPWRPWWWNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLPPWRPWWWNR 12 1 Q9UHR6 Q9UHR6 ZNHIT2 Zinc finger HIT domain-containing protein 2 0 5563200.0 2278000.0 1511400.0 1773800.0 False True 1894257.9325109865 1503257.7882105901 2144693.3788754493 1.0 0.7935866401350659 1.13220767988681 20.85320135874638 -6.741700581961205 1.6803008425984063 0.8774304180013214 1.132488111698507 0.612653415736131 0.08672347034716187 0.31473356257045654 1.7454223822992303 0.04081812279145432 0.09998418724909926 1.8125893253882708e-07 6.741700581961205 0.2550576936971857 LLPQFLLHLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLPQFLLHLDK 11 0 Q8N4J0;Q5T8V1;Q5T8U9 Q8N4J0 C9orf41 UPF0586 protein C9orf41 0 4368900.0 1556200.0 1615200.0 1197500.0 False True 2040193.270262235 1374218.4560002862 1073594.1872311158 1.0 0.6735726835446584 0.5262218059826861 20.960274396443243 -13.999999999999998 0.10732562623281311 2.5830484242100202 0.24519933758822463 0.9997566576980097 0.003088230778383531 12.029043252471945 0.0989641384794316 4.1478684967321815 0.24980180258862916 1.0000000000000041e-14 13.999999999999998 -2.337849086621796 LLPQFLLHLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLPQFLLHLDK 11 0 Q8N4J0;Q5T8V1;Q5T8U9 Q8N4J0 C9orf41 UPF0586 protein C9orf41 0 6551900.0 2206400.0 2575400.0 1770100.0 False True 2136359.0397223006 3603770.65053358 1306457.708138262 1.0 1.6868749978477515 0.6115347110886776 21.02672269823061 -6.734187649946591 1.708234633076046 1.4114226606835167 0.611700584847031 0.5784662932006995 0.28866232693454225 0.32843376984097106 1.8794430119657166 0.133819215662346 0.33046601925896646 1.84421839717404e-07 6.734187649946591 -0.7997220758364857 LLPQFLLHLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLPQFLLHLDK 11 0 Q8N4J0;Q5T8V1;Q5T8U9 Q8N4J0 C9orf41 UPF0586 protein C9orf41 0 8276600.0 1556200.0 1941500.0 4778900.0 False True 2131569.1947237067 1855718.1103180652 3650222.244534949 1.0 0.8705877880537689 1.7124577769140117 21.023484457966134 -6.867680270549671 1.1463743128236303 0.9277494109142003 1.7596199159545491 0.9623085041645182 0.07186171647872767 0.13909428992527237 0.34310361025385583 0.04871691216389371 0.11489069469699548 1.3561874759220594e-07 6.867680270549671 0.8318705050403489 LLPQLTYLDGYDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLPQLTYLDGYDR 13 0 H0YN26;P39687;Q92688-2;Q92688 H0YN26;Q92688-2 ANP32A;ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member B 0 44266500.0 6569500.0 21492000.0 16205000.0 False True 8612678.119128505 18285477.375159852 14528262.049336286 1.0 2.1230884426701544 1.686846048161192 23.03803048388144 -10.102709230031904 4.680841868007086 0.9999435921589258 1.9049672454314361 0.8515845673286219 0.17809521183968577 124002911.22423273 9.633149040465 76300.70898251171 0.060966728059621667 7.893884541377107e-11 10.102709230031904 0.9050236532725103 LLPQLTYLDGYDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLPQLTYLDGYDR 13 0 H0YN26;P39687;Q92688-2;Q92688 H0YN26;Q92688-2 ANP32A;ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member B 0 50335000.0 20555000.0 11368000.0 18412000.0 False True 19902492.77623815 15907301.683336861 13589344.851839846 1.0 0.7992617739989234 0.6827961202962648 24.24644580305529 -13.9999999999998 0.060355352863755846 2.272531696863375 0.16106545257294763 0.9999532883378989 0.0008953982443566601 12.460255426729702 0.06295003536224876 2.390975505525632 0.4887476509010431 1.0000000000004623e-14 13.9999999999998 -2.111466244290427 LLPQLTYLDGYDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLPQLTYLDGYDR 13 0 H0YN26;P39687;Q92688-2;Q92688 H0YN26;Q92688-2 ANP32A;ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member B 0 42242500.0 6569500.0 16740000.0 18933000.0 False True 8998421.684062084 16000371.448222712 14461415.337374752 1.0 1.7781308778363223 1.6071057620014262 23.10124054540433 -10.079396314010317 4.461996854034327 0.9999562079568527 1.6926183197571654 0.9562705620398594 0.06982071156592405 10317529.546408564 7768906.081127059 4838.9755644145225 0.023901487052288714 8.329207585937409e-11 10.079396314010317 0.6926621118003127 LLPQLTYLDGYDRDDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLPQLTYLDGYDRDDK 16 1 H0YN26;P39687 H0YN26 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 0 25658200.0 4189700.0 9852500.0 11616000.0 False True 5492737.273112516 8382545.404744207 10414087.74854 1.0 1.526114392140615 1.8959741255999942 22.38909385629391 -7.483850842048607 0.09975244739215165 4.913099748455505e-15 3.243017721631483 0.9999975097972729 0.0005801042523870235 0.13351515590673876 0.008475086633877273 0.1092825720544655 0.15714000680662 3.2820799642536084e-08 7.483850842048607 3.243017721631478 LLPQLTYLDGYDRDDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLPQLTYLDGYDRDDK 16 1 H0YN26;P39687 H0YN26 ANP32A Acidic leucine-rich nuclear phosphoprotein 32 family member A 0 20703000.0 8067000.0 3600300.0 9035700.0 False True 7810917.500652547 5037918.565316467 6668979.104810397 1.0 0.6449842243111112 0.8538022715325377 22.89706059219802 -10.241969823378161 5.514322297063871 1.0000165565583177 0.749393247921812 0.6575793453959281 0.08524961079619396 1.7353387453098025e-05 2.3856325338134636e-06 0.08254802979667245 0.02751419357368716 5.728358326652684e-11 10.241969823378161 -0.2506233086365057 LLPQVLNSWSIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLPQVLNSWSIGR 13 0 C9JFV4;Q8IZL8;E7EV54 C9JFV4 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 0 5705300.0 1154700.0 2325200.0 2225400.0 False True 1513822.882130706 1978289.2235586122 1995136.9555441553 1.0 1.3068168323457825 1.3179460946818293 20.52976498863759 -11.97460760478991 0.5115516458928437 4.603897035665509e-11 1.3172924571072921 0.9999096309342625 0.0014005280913880523 6.460303504380676 0.25349761188087033 7.048715596832541 0.002218537961263417 1.0602112181570483e-12 11.97460760478991 1.3172924570612532 LLPQVLNSWSIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLPQVLNSWSIGR 13 0 C9JFV4;Q8IZL8;E7EV54 C9JFV4 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 0 6345700.0 2124400.0 1516500.0 2704800.0 False True 2056962.0848377694 2122046.3584430264 1996331.73773932 1.0 1.0316409690217456 0.9705243244173695 20.972083770809455 -6.766019388400912 1.5898274586145584 1.0182410404921638 0.9702323337750873 0.7150197665181837 0.013322387242371026 0.27293332162115186 1.3608255665866675 0.006607784294726072 0.015786537689957112 1.713880792261169e-07 6.766019388400912 -0.048008706717076466 LLPQVLNSWSIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLPQVLNSWSIGR 13 0 C9JFV4;Q8IZL8;E7EV54 C9JFV4 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 0 9191300.0 1154700.0 3468000.0 4568600.0 False True 1581623.7945941817 3314772.2928576055 3489590.773270498 1.0 2.095803252446718 2.206334265580437 20.592975050160483 -10.808175322933584 0.43050285567980356 3.50630511173649e-14 2.2104909591493267 0.9995431432000946 0.011638085094043614 2.4391113999057494 0.20779466237996463 2.5309075311682276 0.026052715001558716 1.5553376213160955e-11 10.808175322933584 2.2104909591492916 LLPSIGLSTVLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLPSIGLSTVLLK 13 0 C9JKF1;Q5K651 C9JKF1 SAMD9 Sterile alpha motif domain-containing protein 9 0 2286320.0 574260.0 1061300.0 650760.0 False True 752860.4211417502 902958.1769149989 583425.5977307063 1.0 1.1993699649473113 0.7749452373202359 19.52202289126996 -6.778942140423365 1.5397474688489683 1.1130415392265425 0.7716790337582936 0.7637226276462101 0.08427544249257016 0.2522146043654763 1.1809691401336482 0.04311024115685219 0.10182277369858334 1.6636342759426061e-07 6.778942140423365 -0.34136250546824887 LLPSIGLSTVLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLPSIGLSTVLLK 13 0 C9JKF1;Q5K651 C9JKF1 SAMD9 Sterile alpha motif domain-containing protein 9 0 4673660.0 574260.0 1400600.0 2698800.0 False True 786579.4407929805 1338716.8608351697 2061399.0235307126 1.0 1.7019474339242309 2.6207130731163506 19.58523295279285 -6.967423081258644 0.313694583569463 0.8644922536897497 3.4875301906639673 0.9999547351006569 0.004464805070959709 0.07714805425772034 0.012008866685675338 0.01430051243082242 0.08128214238649839 1.077896145074403e-07 6.967423081258644 2.6230379369742174 LLPSIGLSTVLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLPSIGLSTVLLK 13 0 C9JKF1;Q5K651 C9JKF1 SAMD9 Sterile alpha motif domain-containing protein 9 0 3761980.0 2089600.0 659180.0 1013200.0 False True 1737594.9849758397 655628.8665030149 1225055.435492504 1.0 0.37731972765341004 0.7050293342723578 20.728660413697337 -10.60554763356803 6.648678509712263 1.001094108886483 0.5411745309629588 0.7232751691832615 0.1337868866707705 0.0021743205199428904 0.00012899768379613747 0.12981098523453033 0.04317953200140275 2.480003915093751e-11 10.60554763356803 -0.45991957792352434 LLPTK(ub)NNVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLPTKNNVR 9 1 Q9H6R4-4;Q9H6R4;A0A0A0MRW6;Q9H6R4-3;Q9H6R4-2 Q9H6R4-4 NOL6 Nucleolar protein 6 1 2302690.0 309130.0 479860.0 1513700.0 True False 299316.8373592067 671470.6004368415 1117216.5599733847 1.0 2.24334389725967 3.7325550070296445 18.19131391094538 -6.968726616247433 0.2869742423167838 0.6982841057439962 5.3234321333166275 0.9999706768703777 0.006048998257849991 0.07671808120223908 0.010501781982878782 0.02644861013679505 0.13552826948422006 1.0746656900743853e-07 6.968726616247433 4.6251480275726315 LLPTK(ub)NNVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLPTKNNVR 9 1 Q9H6R4-4;Q9H6R4;A0A0A0MRW6;Q9H6R4-3;Q9H6R4-2 Q9H6R4-4 NOL6 Nucleolar protein 6 1 1877680.0 309130.0 902490.0 666060.0 True False 257055.29178100135 897628.1072397607 805330.0664865156 1.0 3.491965098327936 3.13290600207763 17.971719186379655 -10.017364093033315 6.83944993175095 0.99999956012558 3.312435550202787 0.9822388547533066 0.14658526221970222 9.830050541274175e-07 1.4162520225597917e-07 0.141930599446163 0.0473101899480273 9.608064435734731e-11 10.017364093033315 2.312435990077207 LLPVYLNCVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLPVYLNCVLK 11 0 G5EA31;P53992;P53992-2 G5EA31 SEC24C Protein transport protein Sec24C 0 7641000.0 1599400.0 2677600.0 3364000.0 False True 2096828.8886116317 2278112.517203055 3015925.549766572 1.0 1.086456090707266 1.4383269737205404 20.99977770466249 -6.944477084618178 0.61651235332025 0.9961379186973021 1.5471752330365225 0.998693398339217 0.006852238897174432 0.08578233180265606 0.04574645870591241 0.006922861703274455 0.029740227047694363 1.1363782566484454e-07 6.944477084618178 0.5510373143392204 LLPVYLNCVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLPVYLNCVLK 11 0 G5EA31;P53992;P53992-2 G5EA31 SEC24C Protein transport protein Sec24C 0 10411500.0 1599400.0 3771900.0 5040200.0 False True 2190741.4021598115 3605244.985994699 3849808.5661773733 1.0 1.6456734612493993 1.7573085359969542 21.06298776618538 -11.339123722311268 0.309919729856053 2.1008879933837636e-13 1.7859624066319837 0.9993610833701192 0.008437692069424234 3.544837002201915 0.162248079224253 2.4524347750245465 0.038603176760739245 4.580113893161754e-12 11.339123722311268 1.7859624066317736 LLQAFLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLQAFLER 8 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 12237000.0 3009200.0 4476000.0 4751800.0 False True 3945090.3411342576 3808198.2473113453 4260129.318484187 1.0 0.965300644095376 1.0798559602210154 21.911626907133012 -6.825448979547745 1.3480609544097022 0.9813927902634464 1.0826629455462518 0.8964729541593709 0.01543235234666433 0.18649562435910355 0.6643915157053525 0.0089921542200898 0.020702385140525924 1.4946896265947327e-07 6.825448979547745 0.10127015528280536 LLQAFLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLQAFLER 8 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 11626800.0 3009200.0 3711600.0 4906000.0 False True 4121782.5605722866 3547609.239380134 3747303.842241615 1.0 0.8606978139301865 0.9091464159432328 21.974836968655904 -10.229526750972434 7.107731499015075 1.0000003843039367 0.8849221156515388 0.8826630003185292 0.019779058947190207 1.2045958710895307e-07 1.3048681205675653e-08 0.01915105539929499 0.006383663825510218 5.894856657580062e-11 10.229526750972434 -0.1150782686523979 LLQAFLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLQAFLER 8 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 6478900.0 2522400.0 1526700.0 2429800.0 False True 2097487.361266775 1518475.3640737766 2937859.9458741522 1.0 0.723949708644106 1.4006568049591657 21.00023068683424 -6.795995986295536 1.4726446308978045 0.8469081743737006 1.40905405814014 0.8200598374383348 0.11785000677754448 0.22653208941913253 0.9703307799109874 0.06297485659836718 0.14679952241250283 1.5995728116320318e-07 6.795995986295536 0.5621458837664395 LLQDFFNGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLQDFFNGR 9 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 22456400.0 6139800.0 7337600.0 8979000.0 False True 8049337.257907772 6242858.681740776 8049939.212649842 1.0 0.7755742468869361 1.0000747831433547 22.940438573161313 -10.927348398501934 9.364722639888727 1.0234172476749046 0.887824515014081 0.24975016755348634 0.09165196013490341 0.043230636008854614 0.00033538323446807996 0.08561397456153151 0.029580542937478915 1.182092880017287e-11 10.927348398501934 -0.1355927326608236 LLQDFFNGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLQDFFNGR 9 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 16100200.0 7092900.0 3399500.0 5607800.0 False True 6867739.771957162 4756938.078158301 4138948.949606092 1.0 0.6926497270007471 0.6026653727484754 22.71140394401373 -13.999999999999998 0.17220648372985323 2.559132672730716 0.525125070457817 0.9995096414192616 0.003766914680767231 12.113750297586424 0.13145109821668874 6.310679146091083 0.07191511083998019 1.0000000000000041e-14 13.999999999999998 -2.034007602272899 LLQDFFNGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLQDFFNGR 9 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 32310800.0 6139800.0 14238000.0 11933000.0 False True 8409849.981856199 13608918.081230275 9114671.167849407 1.0 1.6182117529552593 1.0838090081884721 23.003648634684204 -10.227496767523323 4.622119809434386 0.9999056553393427 1.3510103805739881 0.3651719466882777 0.21816900697749145 153781534.95245782 25.8132360554523 154411.23757226864 0.07468505404270327 5.922474949889884e-11 10.227496767523323 0.3511047252346454 LLQDFFNGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLQDFFNGR 9 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 13014100.0 7092900.0 4049000.0 1872200.0 False True 5898060.618747662 4027187.233336429 2263668.3639252544 1.0 0.6827985491596259 0.3837987620422084 22.491809219448005 -7.208178745162523 0.235041609368477 1.1282811049735855 1.7761039369615405e-12 0.9999733796340341 0.0012981139081159766 0.09188607397338636 0.011863933432689117 0.012489384362953606 0.03897573921766396 6.191861804877393e-08 7.208178745162523 -1.1282811049718093 down LLQDFFNGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLQDFFNGR 9 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 39621400.0 9663400.0 0.0 29958000.0 False True 12509461.794091675 0.0 24505951.395038016 1.0 0.0 1.9589932643315147 23.57651638467466 -6.767941137484898 1.5824153992689338 0.42492486059522616 1.9691513301596228 0.7226284826335425 0.4212306481514976 0.2697516004256598 1.3327559841442884 0.20986529973000465 0.5004996542191614 1.7063136401712419e-07 6.767941137484898 1.5442264695643968 LLQDHPWLLSQNLVVKPDQLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLQDHPWLLSQNLVVKPDQLIK 22 1 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 0 9138900.0 3701800.0 3517300.0 1919800.0 False True 4853095.648282192 2992532.550328019 1721157.5120219574 1.0 0.6166234435101768 0.3546514712998044 22.210473863372826 -8.171548365834822 0.1902423075294744 1.2892008316329935 6.559084074304641e-13 0.9998330719808203 0.003423965101305029 0.08680563036856319 0.03819767801327208 0.10286576140657272 0.11481847588067463 6.736768662915655e-09 8.171548365834822 -1.2892008316323376 down LLQDHPWLLSQNLVVKPDQLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLQDHPWLLSQNLVVKPDQLIK 22 1 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 0 74835700.0 25928700.0 23392000.0 25515000.0 False True 25105607.61115279 32732547.587668486 18831856.066407394 1.0 1.3037942795348854 0.7501055683687824 24.581506306046194 -6.757726890460723 1.620833202105611 1.1769611031931777 0.7482950641967232 0.6816527014295171 0.12773957655198565 0.2867752227138944 1.4842866541156265 0.062195604048751206 0.14981477669647042 1.74692037234327e-07 6.757726890460723 -0.4286660389964545 LLQDHPWLLSQNLVVKPDQLIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLQDHPWLLSQNLVVKPDQLIK 22 1 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 0 105517900.0 15378000.0 63198900.0 26941000.0 False True 23329550.282391608 51920562.5197405 21616099.54134021 1.0 2.2255277916320773 0.926554489035965 24.475655161348616 -6.659351808979638 1.975850608862364 1.789290760002462 0.9320429818794248 0.23269270989177482 0.5218848131524764 0.48590650007238545 3.6461852135034882 0.2134823753375935 0.5782567274714511 2.191029328890625e-07 6.659351808979638 -0.8572477781230371 LLQDHPWLLSQNLVVKPDQLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLQDHPWLLSQNLVVKPDQLIK 22 1 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 0 13910000.0 3701800.0 1922300.0 8285900.0 False True 5070455.497383513 1837366.4298039745 6328941.073467147 1.0 0.36236713461977993 1.2481997084350795 22.273683924895717 -6.713531326891016 1.7823804228484725 0.609420948837165 1.2463630738213094 0.48192720964774216 0.2685520973506765 0.368040850012582 2.28125317773944 0.1197991136683225 0.3030768452456653 1.9340543447699344e-07 6.713531326891016 0.6369421249841444 LLQDHPWLLSQNLVVKPDQLIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLQDHPWLLSQNLVVKPDQLIK 22 1 P53396;P53396-2;P53396-3;K7ESG8 P53396 ACLY ATP-citrate synthase 0 53777700.0 25928700.0 10045000.0 17804000.0 False True 21560862.886171028 9990885.591223601 21526734.08360499 1.0 0.4633806004875472 0.9984170947727734 24.36191158148047 -10.915213823724853 9.859093250857152 1.0392645603760342 0.7308988476301606 0.2522188551665093 0.218427734127722 0.12048274582776504 0.001036125343337807 0.13516705499440526 0.07049724805220736 1.2155873621077884e-11 10.915213823724853 -0.30836571274587365 LLQEHSGIFGFSVSHTTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLQEHSGIFGFSVSHTTR 18 0 B1ANH0;B1ANG9;B1ANH2;Q16774;Q16774-2;Q16774-3;B1ANH6 B1ANH0 GUK1 Guanylate kinase 0 17867400.0 4997700.0 8435000.0 4434700.0 False True 6552033.097795645 7176530.879372479 3975839.7846461996 1.0 1.0953135877452969 0.6068100886095683 22.64351121413964 -6.856077770192568 1.2053611024642772 1.0512661573126432 0.5848625956009165 0.9486965502000166 0.047889148203258326 0.15089652299899156 0.41884014300111355 0.03103277558879856 0.0721507852738283 1.3929073492289056e-07 6.856077770192568 -0.4664035617117267 LLQEHSGIFGFSVSHTTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLQEHSGIFGFSVSHTTR 18 0 B1ANH0;B1ANG9;B1ANH2;Q16774;Q16774-2;Q16774-3;B1ANH6 B1ANH0 GUK1 Guanylate kinase 0 20806300.0 9218700.0 4896700.0 6690900.0 False True 8926057.414561247 6851977.845953163 4938352.567302585 1.0 0.7676376621525424 0.5532512662585563 23.089591655707398 -6.972090747138288 0.2021099082750079 1.124184987042988 0.19077120198461364 0.9999944242652038 0.0004307416915650601 0.0756300206514676 0.006542882164870684 0.006841057245363345 0.0226397210182287 1.0663732760454586e-07 6.972090747138288 -0.9334137850583745 LLQEHSGIFGFSVSHTTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLQEHSGIFGFSVSHTTR 18 0 B1ANH0;B1ANG9;B1ANH2;Q16774;Q16774-2;Q16774-3;B1ANH6 B1ANH0 GUK1 Guanylate kinase 0 72334000.0 17224000.0 22915000.0 32195000.0 False True 26130067.24306892 18825639.214287803 25831644.138430186 1.0 0.7204588889560306 0.9885793212140359 24.63920750150312 -10.649146882286624 8.894611789238445 1.0001101802330923 0.854519105151463 0.2818910004400209 0.10945970810776266 0.00023933910086731874 9.440811309076452e-06 0.10606363595966367 0.03532796888184081 2.2431231511219604e-11 10.649146882286624 -0.14559107508162927 LLQEHSGIFGFSVSHTTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLQEHSGIFGFSVSHTTR 18 0 B1ANH0;B1ANG9;B1ANH2;Q16774;Q16774-2;Q16774-3;B1ANH6 B1ANH0 GUK1 Guanylate kinase 0 22746300.0 4997700.0 8315900.0 9432700.0 False True 6845484.7477642195 7948476.040996121 7204890.532554519 1.0 1.1611268352605921 1.0525026054448057 22.70672127566253 -10.323291851888754 3.7806041961319714 0.9997055788489473 1.1068147203142078 0.563181593434622 0.04434565620013964 31550851.089797452 37.32908557986592 81105.4363980939 0.015180697631860153 4.750159014146124e-11 10.323291851888754 0.10710914146526052 LLQEHSGIFGFSVSHTTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLQEHSGIFGFSVSHTTR 18 0 B1ANH0;B1ANG9;B1ANH2;Q16774;Q16774-2;Q16774-3;B1ANH6 B1ANH0 GUK1 Guanylate kinase 0 17053900.0 9218700.0 4188000.0 3647200.0 False True 7665757.507655409 4165438.412747088 4409812.65725253 1.0 0.5433824913698708 0.5752611731911256 22.869996931141674 -10.39398123664215 6.654601429192388 1.0000408607439535 0.5593218322805 0.9960905307591231 0.01301441735576868 7.890357790087895e-06 7.185620120965986e-07 0.01260231891566272 0.0042003851399570755 4.036628325319553e-11 10.39398123664215 -0.44071902846345345 LLQEHSGIFGFSVSHTTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLQEHSGIFGFSVSHTTR 18 0 B1ANH0;B1ANG9;B1ANH2;Q16774;Q16774-2;Q16774-3;B1ANH6 B1ANH0 GUK1 Guanylate kinase 0 70200000.0 17224000.0 30780000.0 22196000.0 False True 22296807.535798512 29067065.942205463 18156555.750192434 1.0 1.3036425010861756 0.8143119018739019 24.41033382359557 -6.738871025060591 1.6908063035203875 1.1809009943500774 0.814093519910569 0.5998806171312168 0.1275813544795647 0.31985912783302145 1.7950308224832463 0.059703574072320895 0.14669049290415498 1.824437435592283e-07 6.738871025060591 -0.36680747443950845 LLQEK(ub)ELQEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLQEKELQEEK 11 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 4668600.0 1730200.0 1648500.0 1289900.0 True False 2268308.955280636 1402550.2258026698 1156433.5215945018 1.0 0.6183241584165706 0.5098218736483485 21.113185725430867 -13.999999999999998 0.17641507452904265 2.9592539688155113 0.42036609619129794 0.9995029024103467 0.004686946852798867 12.160416432952292 0.13310996665496957 8.160643227239987 0.08354890202337231 1.0000000000000041e-14 13.999999999999998 -2.5388878726242132 LLQEK(ub)ELQEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLQEKELQEEK 11 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 9231700.0 2563400.0 3197100.0 3471200.0 True False 2482026.270134219 4473718.70265625 2561988.5862321556 1.0 1.802446153164337 1.0322165470446905 21.24308695457157 -10.46984563469313 4.815653031928689 0.9988320037717804 1.4173313501045648 0.281317807995332 0.31444491996321833 0.003953513951135 0.00043524019942134493 0.30526039251252757 0.1014866615263913 3.389646160602681e-11 10.46984563469313 0.4184993463327844 LLQEK(ub)ELQEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLQEKELQEEK 11 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 21782700.0 4269900.0 7887400.0 9625400.0 True False 6477750.471503701 6479831.845462522 7722935.471037303 1.0 1.0003213112280223 1.1922249097138429 22.62706146467899 -6.907263632056057 0.914163798410475 0.993531940587685 1.2156270077255995 0.9898474125046351 0.009122818346345601 0.10625553086870625 0.14878697819015738 0.00736935852027133 0.01997708762829134 1.238044821541296e-07 6.907263632056057 0.2220950671379145 LLQEK(ub)ELQEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLQEKELQEEK 11 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 4459200.0 1730200.0 1473800.0 1255200.0 True False 2369901.696896905 1408682.6427951388 958747.6116554576 1.0 0.5944055167518701 0.40455163727289606 21.17639578695376 -13.999999999777197 0.10133920046442407 2.9954202761111057 0.008448889229424723 0.9997869917510915 0.003624649216135253 12.07040164027825 0.0950720059592101 5.020254566179246 0.3530110458738215 1.000000000513023e-14 13.999999999777197 -2.986971386881681 LLQEK(ub)ELQEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLQEKELQEEK 11 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 7963300.0 2563400.0 3253100.0 2146800.0 True False 2131580.6778747435 3235574.9046102054 2595685.954318305 1.0 1.51792279700911 1.2177282245334902 21.023492230005846 -10.206181819628673 4.890418407600696 0.9999517474513175 1.3678255107719834 0.6668645375841784 0.1225539210221425 6.448684906461766e-05 1.0467532113393883e-05 0.11867785549438273 0.039554107927250164 6.220398104679429e-11 10.206181819628673 0.3678737633206659 LLQEK(ub)ELQEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLQEKELQEEK 11 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 25396700.0 4269900.0 13943600.0 7183200.0 True False 5527469.722312231 13167626.40259052 5875931.305856111 1.0 2.3822159259304434 1.0630417896523754 22.39818778677144 -6.635232892213769 2.0616046491509166 1.9071299905030257 1.0684562647742626 0.13661809953713555 0.5921162840173649 0.5454880558913036 4.424911509269168 0.2343678208879838 0.6557417071003052 2.316152270639419e-07 6.635232892213769 -0.8386737257287631 LLQELSHPNIIGLLDAFGHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLQELSHPNIIGLLDAFGHK 20 0 P50613;D6RAD4 P50613 CDK7 Cyclin-dependent kinase 7 0 11250300.0 4266200.0 3180500.0 3803600.0 False True 6472137.300997469 2612914.92564008 3051816.792822895 1.0 0.4037174744790078 0.4715315282870401 22.625810782989323 -10.321773349048987 5.718772131075649 1.0000743708458992 0.4376245013849365 0.9892120896592136 0.027684971536565725 2.6254761408984442e-05 3.113756306371292e-06 0.02680937719973311 0.008935286141777014 4.766796929784064e-11 10.321773349048987 -0.5624498694609628 LLQISLWGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLQISLWGNK 10 0 F5GZY1;Q9H993 F5GZY1 ARMT1 Protein-glutamate O-methyltransferase 0 7101050.0 4647100.0 1491200.0 962750.0 False True 4499580.35419393 2086643.9365052667 710576.8931190958 1.0 0.46374189863291715 0.1579207030844082 22.101359026509986 -8.621665063879467 0.2930499721632704 1.1999284268174704 4.045006072636112e-18 0.9988059675399065 0.01202649936845504 0.22744339152473256 0.08556390244900695 0.14285907691674882 0.09907553530389389 2.3896535184398917e-09 8.621665063879467 -1.1999284268174704 LLQISLWGNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLQISLWGNK 10 0 F5GZY1;Q9H993 F5GZY1 ARMT1 Protein-glutamate O-methyltransferase 0 92797000.0 30996000.0 32712000.0 29089000.0 False True 47023198.11113348 26874288.01997742 23339546.399838377 1.0 0.5715112774010688 0.4963411111400433 25.48686932617504 -13.999999999999998 0.24483512284846146 3.904100323566913 0.46459586022052834 0.9995332542106653 0.004792740724481685 13.799048448324982 0.15658649251463816 19.648495734858702 0.03571562023776484 1.0000000000000041e-14 13.999999999999998 -3.4395044633463847 LLQISLWGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLQISLWGNK 10 0 F5GZY1;Q9H993 F5GZY1 ARMT1 Protein-glutamate O-methyltransferase 0 20517800.0 1965100.0 8389700.0 10163000.0 False True 2691650.574830718 8019015.312972155 7762708.713555139 1.0 2.9792185464030685 2.883995711086439 21.360059703388657 -10.346349488464982 4.613861957071054 0.9981376316987086 2.931607128748205 0.9981806550882263 0.038874559742926286 0.0007451478820931209 0.00010556561378735728 0.03766138446576728 0.012546710204627798 4.5045406613100066e-11 10.346349488464982 1.9334694970494963 LLQISLWGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLQISLWGNK 10 0 F5GZY1;Q9H993 F5GZY1 ARMT1 Protein-glutamate O-methyltransferase 0 12317900.0 4647100.0 1980000.0 5690800.0 False True 3864269.551436261 1969333.3470007717 6880719.9687137185 1.0 0.5096262879148312 1.7806004154540183 21.881764301944262 -6.80209900215636 1.4472682749483772 0.7301480198301759 1.799079481177865 0.8382330620546362 0.21049792726088035 0.21778192896422777 0.9003373736608886 0.11440749215666034 0.26574385928702277 1.5772516770192587e-07 6.80209900215636 1.068931461347689 LLQISLWGNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLQISLWGNK 10 0 F5GZY1;Q9H993 F5GZY1 ARMT1 Protein-glutamate O-methyltransferase 0 77766000.0 30996000.0 23510000.0 23260000.0 False True 40124933.02250405 22201647.83304904 19026918.66775434 1.0 0.553313019129459 0.4741919109767262 25.25799564826749 -13.999999999999998 0.24346803996884736 4.00710989216493 0.4403415889229626 0.999530853323953 0.005013892300426076 13.748423508370571 0.15615451183392356 20.141386182423343 0.037889219864949794 1.0000000000000041e-14 13.999999999999998 -3.5667683032419677 LLQK(ub)GIHPTIISESFQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLQKGIHPTIISESFQK 17 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 1 15917400.0 1809300.0 9490900.0 4617200.0 True False 2372009.821286126 8074894.715238451 4139456.4353098143 1.0 3.4042416868494105 1.7451261787210317 21.177678552686782 -9.524500524063358 8.514618960695937 0.9999999980852875 2.5746839327852395 0.5456777751781321 0.6773310698755614 0.0 0.0 0.6558229932604572 0.21860766279139832 2.988818040349049e-10 9.524500524063358 1.574683934699952 LLQK(ub)GIHPTIISESFQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLQKGIHPTIISESFQK 17 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 1 21954400.0 9917500.0 6680200.0 5356700.0 True False 9602674.391065035 9347638.696782792 3953619.572444625 1.0 0.9734411806653004 0.4117206739950836 23.195004828636634 -6.916762073222683 0.8483934701253887 1.0138986043562894 0.3275568247861505 0.9932331757398353 0.022315218083898202 0.10011477838909182 0.11576298801053558 0.018904149712828864 0.054986915043029834 1.2112615373884524e-07 6.916762073222683 -0.686341779570139 down LLQK(ub)GIHPTIISESFQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLQKGIHPTIISESFQK 17 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 1 15937100.0 1809300.0 7417600.0 6710200.0 True False 2478247.10449403 7089865.905276989 5125388.960906989 1.0 2.860838974620526 2.0681508924645393 21.240888614209673 -10.629659378897033 6.204570905063708 0.9926229427731413 2.4644949335425075 0.8198532959093636 0.32361355441125966 0.032824029208194765 0.0019592100486681696 0.311444542600888 0.10444582557014968 2.3460681364552705e-11 10.629659378897033 1.4718719907693663 LLQK(ub)GIHPTIISESFQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLQKGIHPTIISESFQK 17 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 1 24083000.0 9917500.0 11750900.0 2414600.0 True False 8246840.669744387 11687595.569328962 2919481.6961510065 1.0 1.4172209743554098 0.35401213786776076 22.97541010407091 -6.800271588644384 1.4548819409104472 1.2301214894973604 0.33925076812027116 0.8329280138467654 0.17878053637807262 0.22037484950506228 0.9208980885398985 0.09667188231456761 0.2247781741968929 1.583902379888493e-07 6.800271588644384 -0.8908707213770892 down LLQK(ub)GIHPTIISESFQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLQKGIHPTIISESFQK 17 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 1 19567200.0 2930600.0 1757200.0 14879400.0 True False 3793719.470762372 1659410.2752970562 12171501.87553673 1.0 0.43740985280695704 3.2083294427383664 21.8551815709246 -6.853844877423874 1.2164187044169716 0.6984934309270754 3.3275767678211237 0.9457121513205695 0.2786377478272123 0.15327860048508507 0.4345196765347563 0.1790505483561786 0.41547678735658594 1.400087320565269e-07 6.853844877423874 2.6290833368940483 up LLQLGHK(ub)GGGVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLQLGHKGGGVVK 13 1 O60346 O60346 PHLPP1 PH domain leucine-rich repeat-containing protein phosphatase 1 1 8675500.0 1389200.0 2980900.0 4305400.0 True False 2107517.964123972 2448935.1051219977 3454435.802876143 1.0 1.161999635025622 1.6391014746638428 21.007113497830613 -6.951865328893346 0.5379761584540007 0.992880793114419 1.8301766271541138 0.9993396519056484 0.006971066713062395 0.0827452645169857 0.03292860700919289 0.007688871625099601 0.03949828271178448 1.1172096314869198e-07 6.951865328893346 0.8372958340396948 LLQLGHK(ub)GGGVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLQLGHKGGGVVK 13 1 O60346 O60346 PHLPP1 PH domain leucine-rich repeat-containing protein phosphatase 1 1 3207160.0 623800.0 1976400.0 606960.0 True False 518717.3390256164 1965752.7409153164 733872.5297340411 1.0 3.7896414733463137 1.4147831092605898 18.984589069525057 -6.606872138908939 2.1649408303229998 2.8676616106392334 1.423008808258692 0.040815591389648076 1.2036631923514345 0.6214045985807806 5.514264404697381 0.4598192059229447 1.337265419585664 2.472451955030219e-07 6.606872138908939 -1.4446528023805414 LLQLGHK(ub)GGGVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLQLGHKGGGVVK 13 1 O60346 O60346 PHLPP1 PH domain leucine-rich repeat-containing protein phosphatase 1 1 6991500.0 1389200.0 3975300.0 1627000.0 True False 1798346.7852259204 3754071.0604304494 1330902.6944297662 1.0 2.0875123147946337 0.7400701051452483 20.778239819923062 -6.691976284261062 1.8599560283157857 1.6805532329592663 0.744681820037723 0.3794817372771736 0.45976009590331635 0.4124085984337577 2.767778494514568 0.197661225184904 0.5133384253809719 2.0324679959160953e-07 6.691976284261062 -0.9358714129215433 LLQLILGCAINCEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLQLILGCAINCEK 14 0 Q9UJC3;Q9UJC3-2;B1AK95 Q9UJC3 HOOK1 Protein Hook homolog 1 0 25858700.0 6480500.0 9683300.0 9694900.0 False True 9831392.288011368 7955239.4590317765 7778698.765574371 1.0 0.8091671277050538 0.7912102922655115 23.22896430987517 -13.99999999982968 0.33432124716005485 3.1322878623701365 0.7881888018896341 0.9997237363625144 0.0015703051633096147 19.194819496098575 0.1851349858371624 28.842774915336523 0.005663073466119444 1.0000000003921778e-14 13.99999999982968 -2.3440990604805023 LLQLILGCAINCEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLQLILGCAINCEK 14 0 Q9UJC3;Q9UJC3-2;B1AK95 Q9UJC3 HOOK1 Protein Hook homolog 1 0 17290300.0 6480500.0 5517900.0 5291900.0 False True 8389134.999752784 5210824.014376076 4328828.499479329 1.0 0.6211396067091103 0.5160041529438844 23.00009063196762 -13.99999999999995 0.1798543250924219 2.964857294603233 0.4323638829236215 0.9994983139989679 0.004655648975864018 12.20285934098082 0.13443903327112028 8.378588706862075 0.0785952756479009 1.0000000000001145e-14 13.99999999999995 -2.532493411679612 LLQLPSTTIENISVSVHQPQPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLQLPSTTIENISVSVHQPQPK 22 0 Q5T6F2 Q5T6F2 UBAP2 Ubiquitin-associated protein 2 0 9596000.0 4715700.0 2535000.0 2345300.0 False True 4566002.684743679 3547238.719850361 1730995.5725081454 1.0 0.776880559379148 0.37910524632232406 22.1225002771709 -6.962229423438088 0.4027851278771976 1.0212057052380483 0.12019025252509519 0.9998441536365669 0.003205850340151599 0.07891414880131126 0.018257947477953746 0.005117189947118165 0.0332931023082034 1.0908639168142035e-07 6.962229423438088 -0.9010154527129531 down LLQLPSTTIENISVSVHQPQPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLQLPSTTIENISVSVHQPQPK 22 0 Q5T6F2 Q5T6F2 UBAP2 Ubiquitin-associated protein 2 0 31115900.0 8215900.0 12491000.0 10409000.0 False True 12464120.962745583 10261883.45737155 8351656.587573219 1.0 0.8233138532627875 0.6700558035769837 23.57127780396785 -6.972789059421435 0.17947994789748636 1.1192962964536983 0.36993117727661556 0.9999967568637049 0.00024271089352002643 0.07540775164702053 0.005656893361083236 0.005929017684081783 0.017226203429775974 1.0646600072164883e-07 6.972789059421435 -0.7493651191770827 LLQLPSTTIENISVSVHQPQPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLQLPSTTIENISVSVHQPQPK 22 0 Q5T6F2 Q5T6F2 UBAP2 Ubiquitin-associated protein 2 0 23935100.0 8215900.0 8841300.0 6877900.0 False True 10635644.509600963 8349273.882872688 5626192.77321357 1.0 0.7850275434963689 0.5289940603162053 23.3424041260603 -6.968806731133249 0.2852497247672258 1.0529564950280113 0.2532067200921417 0.999971520869228 0.0010274404726324294 0.0766918087842387 0.010409378154218529 0.004590747382676799 0.023348920792086388 1.0744674633366817e-07 6.968806731133249 -0.7997497749358695 LLQQLFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLQQLFLK 8 0 Q9P287-4;Q9P287-3;Q9P287;Q9P287-2 Q9P287-4 BCCIP BRCA2 and CDKN1A-interacting protein 0 8021400.0 2376400.0 2931000.0 2714000.0 False True 3115483.4130903394 2493706.2249485147 2433181.3145263 1.0 0.8004235280055413 0.7809963950707591 21.57102460530476 -13.999999999999998 0.3293919985065878 3.164582711260702 0.7775313245716423 0.9997135754661847 0.0016751109116956505 18.772140297624563 0.1834951523839352 28.141326841550846 0.006239625548874708 1.0000000000000041e-14 13.999999999999998 -2.38705138668906 LLQQLFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLQQLFLK 8 0 Q9P287-4;Q9P287-3;Q9P287;Q9P287-2 Q9P287-4 BCCIP BRCA2 and CDKN1A-interacting protein 0 6295120.0 3026900.0 955920.0 2312300.0 False True 2930812.7163412888 1337623.841056944 1706639.2624869233 1.0 0.4564003129912651 0.5823092185219616 21.482869349757507 -9.957765494257167 7.059170752922243 1.0000000211112188 0.5193547657567458 0.9510526219824187 0.05140209543708583 1.7129810418161545e-08 2.521414039813642e-09 0.04976986712187846 0.01658995496566603 1.102134267707097e-10 9.957765494257167 -0.480645255354473 LLQQLFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLQQLFLK 8 0 Q9P287-4;Q9P287-3;Q9P287;Q9P287-2 Q9P287-4 BCCIP BRCA2 and CDKN1A-interacting protein 0 10000700.0 2376400.0 3307500.0 4316800.0 False True 3255019.2997952877 3161363.7135601277 3297260.747286716 1.0 0.971227333048056 1.0129773262770163 21.634234666827652 -6.721278229947975 1.7547890876247532 0.9825189646746301 1.0129166484036152 0.5185159220949294 0.012105775018478216 0.35283669366108183 2.124041179487423 0.005476306087144489 0.013726555605855546 1.899860747723588e-07 6.721278229947975 0.030397683728985103 LLQQLFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLQQLFLK 8 0 Q9P287-4;Q9P287-3;Q9P287;Q9P287-2 Q9P287-4 BCCIP BRCA2 and CDKN1A-interacting protein 0 6206200.0 3026900.0 1849100.0 1330200.0 False True 2517001.4644062785 1839138.5312823893 1608338.6698501087 1.0 0.7306863175449974 0.63898996190274 21.263274625191784 -13.999999999999998 0.15039907160076266 2.3030503536461593 0.5385671805291363 0.9995649120752886 0.003195815470451811 11.959187439695608 0.1221570692553534 4.553609394059906 0.09055003761024938 1.0000000000000041e-14 13.999999999999998 -1.764483173117023 LLQQNTQLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLQQNTQLKR 10 1 Q01664;I3L254 Q01664 TFAP4 Transcription factor AP-4 1 8173800.0 2411000.0 2945600.0 2817200.0 True False 3160844.3481572135 2506127.9618588705 2525703.168490602 1.0 0.7928666159470821 0.7990596468197172 21.591878562595486 -10.397234283004273 5.8164964441307605 1.0000636390957598 0.7959631313833994 0.999309517394729 0.002528294266544165 2.087130667677385e-06 2.162884566847449e-07 0.002448772144638446 0.0008160034657196363 4.0065052576782686e-11 10.397234283004273 -0.20410050771236043 LLQQNTQLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLQQNTQLKR 10 1 Q01664;I3L254 Q01664 TFAP4 Transcription factor AP-4 1 14905200.0 3396000.0 4978000.0 6531200.0 True False 3288195.8388764206 6965741.359927065 4820482.788199882 1.0 2.118408300859375 1.4659962558212607 21.64886479515703 -10.09385879991303 4.891323060981857 0.9999712347115552 1.7922022783439475 0.6628370698992696 0.2663461020835471 8.505472099203947e-05 1.5756465641323544e-05 0.2578980060129724 0.08596283480540193 8.056403326096744e-11 10.09385879991303 0.7922310436323923 LLQQNTQLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLQQNTQLKR 10 1 Q01664;I3L254 Q01664 TFAP4 Transcription factor AP-4 1 14794800.0 4249500.0 5377800.0 5167500.0 True False 6446802.180063942 4418089.573056821 4146141.3600042886 1.0 0.6853148971623944 0.6431314695564562 22.62015228443514 -13.999999999999998 0.28320572163169816 3.610521470665441 0.6308286045750573 0.9996122913116741 0.0031351026890145757 15.574294090494325 0.16863090563959326 23.592999198022856 0.016436517601681362 1.0000000000000041e-14 13.999999999999998 -2.979692866090384 LLQQNTQLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLQQNTQLKR 10 1 Q01664;I3L254 Q01664 TFAP4 Transcription factor AP-4 1 7607600.0 2411000.0 2734200.0 2462400.0 True False 3302411.854825128 2613394.0032097073 1880831.8347198877 1.0 0.7913591999106041 0.5695327891861275 21.655088624118378 -6.9703478551665725 0.24973869176406993 1.0706239886293079 0.28377316665602775 0.999984968890924 0.0006814159248591894 0.07618999849371294 0.008625368075934357 0.004956325205771666 0.02126903950295925 1.0706613981991397e-07 6.9703478551665725 -0.7868508219732802 LLQQNTQLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLQQNTQLKR 10 1 Q01664;I3L254 Q01664 TFAP4 Transcription factor AP-4 1 12368100.0 3396000.0 6900500.0 2071600.0 True False 2823924.468308745 6863325.636857994 2504761.9820038243 1.0 2.4304211085958882 0.8869790995167559 21.429270070591308 -6.6631942682293275 1.961207669013324 1.91828318616658 0.8933205734646489 0.2494525609684175 0.6085729991088247 0.47689162039754907 3.529308262937511 0.25039074362110464 0.6750463570207762 2.1717295054053377e-07 6.6631942682293275 -1.024962612701931 LLQQQQLFLQLQILSQQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLQQQQLFLQLQILSQQK 18 0 I3L2S3;Q9ULH7-2;Q9ULH7-3;Q9ULH7-4;Q9ULH7;Q9ULH7-5 I3L2S3 MKL2 Phosphatase and actin regulator;MKL/myocardin-like protein 2 0 78348000.0 20058000.0 31496000.0 26794000.0 False True 30429452.43622134 25875292.720628824 21498154.155772626 1.0 0.8503371125347124 0.7064916531387385 24.858965037674444 -6.97160860900468 0.21634883686945922 1.069470857049111 0.48331324867684716 0.9999923547600943 0.0003312858465135141 0.07578416783057981 0.00713240673480195 0.004098116089008629 0.014694497222758427 1.0675577827282826e-07 6.97160860900468 -0.5861576083722637 LLQQQQLFLQLQILSQQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLQQQQLFLQLQILSQQK 18 0 I3L2S3;Q9ULH7-2;Q9ULH7-3;Q9ULH7-4;Q9ULH7;Q9ULH7-5 I3L2S3 MKL2 Phosphatase and actin regulator;MKL/myocardin-like protein 2 0 48085000.0 20058000.0 10836000.0 17191000.0 False True 25965476.402290206 10232967.074390467 14062414.394555679 1.0 0.3940989533890431 0.5415812202588876 24.630091359766894 -10.239356340428001 8.311313476108955 1.0000002535678911 0.4678400868244811 0.9455330239532422 0.06020938332334922 2.8289704191241144e-07 2.5816515997616552e-08 0.05829751252121719 0.019432494908062502 5.76293418205414e-11 10.239356340428001 -0.53216016674341 LLQQVSQIYQSIEFSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLQQVSQIYQSIEFSR 16 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 13280300.0 6009700.0 3346800.0 3923800.0 False True 5818925.36304346 4683194.693331435 2896039.0685231965 1.0 0.8048212343596712 0.4976931113288051 22.472321310677607 -6.9644491757631775 0.36738252511829445 1.0243304631097314 0.2675370145327502 0.9999013368644476 0.0020536911607320664 0.07814837151473433 0.015522001891498119 0.004065016034011191 0.026121426370023335 1.0853025520441955e-07 6.9644491757631775 -0.7567934485769812 down LLQQVSQIYQSIEFSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLQQVSQIYQSIEFSR 16 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 12765200.0 6009700.0 2285900.0 4469600.0 False True 4997331.824851305 2273585.4029843733 5404172.694904557 1.0 0.45495986311695913 1.0814116181018973 22.252726586111883 -6.6766295525492945 1.9132416373164998 0.6541318046967087 1.0790074308704571 0.30911491711663386 0.2311689229991435 0.4460091406571301 3.153317694604978 0.09704333489871796 0.2571141586556417 2.105573700516865e-07 6.6766295525492945 0.4248756261737484 LLQSAK(ub)TILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLQSAKTILR 10 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 29748470.0 7856600.0 21160000.0 731870.0 True False 6533111.006394135 21046006.880068846 884900.6332154544 1.0 3.2214372080117024 0.13544858373742277 22.639338722611946 -6.713547126699256 1.7825376818131458 2.3607366659691413 0.14192404058819455 0.4818870352982779 0.935604192416274 0.3680201314656983 2.281582592742637 0.41734688933608727 1.0557309306368083 1.9339839843734713e-07 6.713547126699256 -2.218812625380947 LLQSIGQAPESISEKELK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLQSIGQAPESISEKELK 18 1 Q13564;Q13564-4;Q13564-3;Q13564-2 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 1 8109800.0 1494300.0 2454800.0 4160700.0 True False 1959041.7708217856 2088553.4087354569 3730190.6762526133 1.0 1.0661096868084357 1.9040894032023932 20.90171672849934 -6.922618436569961 0.8050651844787603 0.9831970871554696 2.0477109954850565 0.9948779927480332 0.02945000352894443 0.09665541232298148 0.09780855367463606 0.02573262912313345 0.07912184437035635 1.195037582197473e-07 6.922618436569961 1.064513908329587 LLQSIGQAPESISEKELK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLQSIGQAPESISEKELK 18 1 Q13564;Q13564-4;Q13564-3;Q13564-2 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 1 18402800.0 1893000.0 2755800.0 13754000.0 True False 1832907.7511758101 3856205.311307151 10151414.7888445 1.0 2.1038730993599626 5.5384210047299804 20.805702747307695 -6.950628413325043 0.5519011043861537 0.9530277608072754 6.851143529662975 0.9992496833825891 0.05293558148236126 0.08323437256302561 0.03492555096771971 0.057315697285574126 0.2850285579042574 1.1203960955152122e-07 6.950628413325043 5.8981157688557 LLQSIGQAPESISEKELK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLQSIGQAPESISEKELK 18 1 Q13564;Q13564-4;Q13564-3;Q13564-2 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 1 86769000.0 10824000.0 17336000.0 58609000.0 True False 16420799.340395836 14242255.353213757 47024905.46076271 1.0 0.8673302107880478 2.86374033845475 23.96902102131242 -6.891012569714196 1.0164077230817825 0.8953194952708923 3.0388734710084946 0.9815373142540743 0.12384645038448233 0.11832408419331804 0.21709625332701718 0.092718499737057 0.23199979303871082 1.2852494606402514e-07 6.891012569714196 2.1435539757376025 up LLQSIGQAPESISEKELK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLQSIGQAPESISEKELK 18 1 Q13564;Q13564-4;Q13564-3;Q13564-2 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 1 8437700.0 1494300.0 2687000.0 4256400.0 True False 2046783.0919391077 2568279.4552792353 3251125.9833096694 1.0 1.2547882896795213 1.5884076803808145 20.964926790022233 -6.96741705191349 0.3138121331132649 0.9508629337610853 1.9029966913014391 0.9999546514278076 0.00162247152204206 0.07715005070018283 0.012015824474201556 0.005190106951655544 0.029511678234548852 1.0779111096969891e-07 6.96741705191349 0.9521337575403538 LLQSQLQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLQSQLQVK 9 0 Q96I25;Q5W011;Q5W010 Q96I25 RBM17 Splicing factor 45 0 16440800.0 2998900.0 6278700.0 7163200.0 False True 3931586.9413889153 5341942.434180909 6422020.7782663265 1.0 1.358724228617403 1.6334423920936143 21.906680327189665 -6.9740914667206315 0.12677854657412382 0.553671201627269 2.4455885668889024 0.999999300124911 0.0002168988660277671 0.0749959015938694 0.0037958735183094565 0.017912989890383486 0.03815995547875924 1.0614719771406171e-07 6.9740914667206315 1.8919173652616332 LLQSQLQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLQSQLQVK 9 0 Q96I25;Q5W011;Q5W010 Q96I25 RBM17 Splicing factor 45 0 7450000.0 2276900.0 1035600.0 4137500.0 False True 2204621.0558120483 1449120.4805826552 3053764.627660619 1.0 0.6573104601184566 1.3851653188242812 21.072099266883278 -6.778672177526555 1.540950223580631 0.8056228361588118 1.3907008550430449 0.7626706891055441 0.14484089993404392 0.2526565377583559 1.1848920562274852 0.07403728601907962 0.17489865652319525 1.6646687333561377e-07 6.778672177526555 0.585078018884233 LLQSQLQVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLQSQLQVK 9 0 Q96I25;Q5W011;Q5W010 Q96I25 RBM17 Splicing factor 45 0 19841400.0 3934200.0 10850000.0 5057200.0 False True 5968469.028546312 8913732.728563072 4057642.203350498 1.0 1.4934705509788182 0.6798464034819298 22.508929482693706 -6.742519635714175 1.6775047031864945 1.2927503494249584 0.6791044207158125 0.6162083726055605 0.20732699193712217 0.3132652005230356 1.7318387769310983 0.09773736525243241 0.23917548826547835 1.809174110391519e-07 6.742519635714175 -0.6136459287091459 LLQSQLQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLQSQLQVK 9 0 Q96I25;Q5W011;Q5W010 Q96I25 RBM17 Splicing factor 45 0 12228700.0 2998900.0 3864200.0 5365600.0 False True 4107674.372225252 3693466.8667994156 4098355.788000735 1.0 0.8991625265560065 0.997731420901441 21.969890388712557 -10.643230994984478 6.224292629716456 1.0003101840598427 0.9484469737287238 0.2672524346916403 0.04024058260943676 0.00017425007440907334 9.987861163930774e-06 0.03919650841601142 0.012987592190669363 2.2738876609503647e-11 10.643230994984478 -0.05186321033111896 LLQSQLQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLQSQLQVK 9 0 Q96I25;Q5W011;Q5W010 Q96I25 RBM17 Splicing factor 45 0 5004820.0 2276900.0 1760400.0 967520.0 False True 1893343.2337727256 1750916.3757879606 1169823.9586929597 1.0 0.9247749401987925 0.6178615360522549 20.852504542317554 -6.944420857865895 0.6170726507604738 1.0033669115183659 0.5230914865210221 0.998687415639453 0.005988357108828985 0.08580661436604523 0.04585265891347872 0.006046941796232604 0.025945776174092383 1.1365253895219036e-07 6.944420857865895 -0.48027542499734377 LLQSQLQVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLQSQLQVK 9 0 Q96I25;Q5W011;Q5W010 Q96I25 RBM17 Splicing factor 45 0 13879500.0 3934200.0 5279700.0 4665600.0 False True 5092899.454675943 4985880.053770703 3816508.673098659 1.0 0.9789865474750377 0.7493783663046025 22.280055804786155 -6.924790295366685 0.7883782803257117 1.0042462831301167 0.7079390447758165 0.9954115535281716 0.00768934443223519 0.09543454396040953 0.09160270626067003 0.006799213947160357 0.02140144104085567 1.1890762494817013e-07 6.924790295366685 -0.2963072383543002 LLQTK(ub)NYDIGAALDTIQYSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLQTKNYDIGAALDTIQYSK 20 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 45450400.0 9957400.0 20918000.0 14575000.0 True False 9641307.787405197 29270666.485928927 10757370.25937246 1.0 3.0359643246911276 1.1157584112629635 23.20079742225614 -6.632384012903408 2.0716380797280194 2.3389887180693556 1.123536238865906 0.12615689312605904 0.8727954527026053 0.5528601281225533 4.524634428740707 0.34419983711631946 0.9668404319459464 2.331395678360819e-07 6.632384012903408 -1.2154524792034496 LLQTK(ub)NYDIGAALDTIQYSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLQTKNYDIGAALDTIQYSK 20 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 174032000.0 25527000.0 82965000.0 65540000.0 True False 38726325.27367739 68159247.54149635 52585990.272797465 1.0 1.7600236288833935 1.3578874293177672 25.206811275286977 -10.056103917440284 4.2345738038736025 0.9999456437698934 1.5589555290082693 0.720358428174463 0.16417141645842415 40595201.5554888 63903588.33751437 29719.746829273707 0.060080584237043974 8.788122105847133e-11 10.056103917440284 0.5590098852383759 LLQTK(ub)NYDIGAALDTIQYSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLQTKNYDIGAALDTIQYSK 20 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 20238500.0 2956100.0 6998400.0 10284000.0 True False 4049050.0555987386 6689187.547386007 7855131.005628362 1.0 1.652038738848554 1.9399935534920951 21.949152047487395 -10.451051198316518 0.17525456071804082 4.29573256220456e-16 2.251075340935904 0.9995391041320222 0.008442025925950697 2.200768165215136 0.08998050562866249 1.1710904358505583 0.21190450468224103 3.539556113346048e-11 10.451051198316518 2.2510753409359037 LLQTK(ub)NYDIGAALDTIQYSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLQTKNYDIGAALDTIQYSK 20 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 34399400.0 9957400.0 13325000.0 11117000.0 True False 8280019.287614098 13253215.580194596 13441513.30079961 1.0 1.6006261724558777 1.6233673900864554 22.981202697690417 -11.384820995471399 0.53666762769746 3.9972001386524973e-16 1.6216063117835804 0.9998947944315038 0.0029606439352789504 3.928901844511181 0.26400990087306464 4.628243513059442 0.004339713167417333 4.122674096434046e-12 11.384820995471399 1.62160631178358 LLQTK(ub)NYDIGAALDTIQYSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLQTKNYDIGAALDTIQYSK 20 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 144355000.0 25527000.0 80968000.0 37860000.0 True False 33045204.712397102 76462059.62340775 30969868.476405006 1.0 2.313862488941476 0.9371970531260313 24.977937597379427 -6.6568687935293935 1.9854158989256374 1.8479450270678637 0.943119001544479 0.22192080481463083 0.5598450049621536 0.49182959569299417 3.724008090031636 0.22815826327247052 0.619877670524304 2.2035920986622868e-07 6.6568687935293935 -0.9048260255233846 LLSALCPEEPPVHSSAQIVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLSALCPEEPPVHSSAQIVSK 21 0 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 0 10133700.0 2128700.0 3959700.0 4045300.0 False True 2790746.314360125 3368928.1947897086 3626731.161257648 1.0 1.2071782295131874 1.2995560157495725 21.412219555194 -13.996407034291222 0.10934986143025106 2.6662454641337955e-19 1.470632775389337 0.999746147974146 0.0019955823119637626 12.003631261854045 0.1002153166433632 2.6540403449363112 0.15196038072837667 1.0083074260193527e-14 13.996407034291222 1.470632775389337 LLSALCPEEPPVHSSAQIVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLSALCPEEPPVHSSAQIVSK 21 0 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 0 8816100.0 2128700.0 3648600.0 3038800.0 False True 2915737.9159544795 3487392.7876932747 2321098.026050517 1.0 1.1960583866645853 0.7960585254764557 21.47542961671689 -6.773418179465893 1.5612581054952364 1.1119625529184096 0.7935063670500282 0.7434916630332883 0.08271096127116123 0.2609432678108363 1.255703775931526 0.04174532557704579 0.09906745374909647 1.6849298355350068e-07 6.773418179465893 -0.3184561858683814 LLSALCPEEPPVHSSAQIVSK(ub)HLVGVDSLIGPETQIGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLSALCPEEPPVHSSAQIVSKHLVGVDSLIGPETQIGEK 39 1 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 104803600.0 6626600.0 12986000.0 85191000.0 True False 10053036.669352083 10668546.83991891 68352961.50945821 1.0 1.061226293189926 6.799235271650865 23.26112801895675 -6.909233244818827 0.900947761741502 0.818003177899424 7.528724345824712 0.9906288184424705 0.2632578655627081 0.1049270405948583 0.1415364718639027 0.21471897655088112 0.5896141199589572 1.2324427523022147e-07 6.909233244818827 6.710721167925288 up LLSALCPEEPPVHSSAQIVSK(ub)HLVGVDSLIGPETQIGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLSALCPEEPPVHSSAQIVSKHLVGVDSLIGPETQIGEK 39 1 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 96924400.0 6626600.0 11928000.0 78369800.0 True False 8578264.32981434 11264196.314445315 64107300.54205396 1.0 1.3131090254815108 7.473225127750457 23.0322543410492 -6.917448675150653 0.8434262083277059 0.8511845974106436 8.41057561625096 0.9934424839352416 0.2413523013496544 0.09969648308713794 0.11356259416249925 0.2051876096878277 0.6004172858373525 1.2093480950542979e-07 6.917448675150653 7.559391018840316 up LLSDATVEKDESHAGK(ub)VVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLSDATVEKDESHAGKVVLR 20 2 Q14320 Q14320 FAM50A Protein FAM50A 1 9770940.0 2831940.0 4411200.0 2527800.0 True False 3712700.764545971 3753066.154722924 2266247.504369781 1.0 1.0108722444217475 0.6104040287897864 21.824037611179264 -6.9006583858919885 0.9570783362803572 1.0163505535537827 0.5677988564962754 0.9868915366652821 0.02132678195217836 0.1109228815698559 0.17469152860630924 0.016691330653035276 0.043574081006990985 1.2570183399535524e-07 6.9006583858919885 -0.4485516970575073 LLSDATVEKDESHAGK(ub)VVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLSDATVEKDESHAGKVVLR 20 2 Q14320 Q14320 FAM50A Protein FAM50A 1 29368800.0 7110300.0 3567200.0 18691300.0 True False 9204423.514966791 3368682.1841791887 15289675.188933657 1.0 0.36598513515828185 1.661122520500277 23.13389593585938 -6.7735982776155 1.5606366703637653 0.6380099996742917 1.6694225483315372 0.7441074596263586 0.26748580170609754 0.260672800633192 1.2534362410654807 0.13505675969472125 0.3204475532730119 1.6842312546242954e-07 6.7735982776155 1.0314125486572454 LLSHGVPLPNWLINSYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLSHGVPLPNWLINSYK 17 0 Q12769;G3V198 Q12769 NUP160 Nuclear pore complex protein Nup160 0 12085200.0 4315000.0 5062300.0 2707900.0 False True 4178022.6869115834 7083702.789545746 1998619.7547413132 1.0 1.6954677655860353 0.478364983752327 21.99438889567031 -6.751707924266788 1.6433949446393126 1.408096848736986 0.47560691166142294 0.6563480621613693 0.29226886923604994 0.2970709723184335 1.5790380109968492 0.14045555157963927 0.3403961706061776 1.7712998087269384e-07 6.751707924266788 -0.932489937075563 LLSHGVPLPNWLINSYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLSHGVPLPNWLINSYK 17 0 Q12769;G3V198 Q12769 NUP160 Nuclear pore complex protein Nup160 0 22730100.0 4732400.0 8273500.0 9724200.0 False True 7179396.784782818 6797029.283849454 7802207.607731736 1.0 0.9467409989452295 1.0867497425785138 22.775431202765123 -6.80359216753046 1.4409861136713995 0.9707475705746142 1.088863326363285 0.8425302251950371 0.022897114855577935 0.21565915133989255 0.8836273038353524 0.012497873590056588 0.029007042958780316 1.5718381759360022e-07 6.80359216753046 0.11811575578867073 LLSHGVPLPNWLINSYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLSHGVPLPNWLINSYK 17 0 Q12769;G3V198 Q12769 NUP160 Nuclear pore complex protein Nup160 0 14224100.0 4315000.0 4380600.0 5528500.0 False True 3588113.686911725 4357000.83831898 6684483.789104134 1.0 1.2142872881123878 1.862952061270233 21.774794171104585 -6.951248504579608 0.544965472323713 0.9907496229205026 2.116701063153054 0.9992956492491998 0.009736700203657066 0.08298826442622546 0.033917379194956174 0.010637699058712103 0.053763107424626616 1.1187975210445757e-07 6.951248504579608 1.1259514402325512 LLSHGVPLPNWLINSYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLSHGVPLPNWLINSYK 17 0 Q12769;G3V198 Q12769 NUP160 Nuclear pore complex protein Nup160 0 14974300.0 4732400.0 6087600.0 4154300.0 False True 6126185.089550208 5748819.708569527 3398260.026717624 1.0 0.9384012439283991 0.5547106359085093 22.546557524857572 -6.935048239526161 0.7041256434278914 1.004888100706428 0.46475740813586236 0.9974406363503201 0.009966465577154422 0.09010015472319048 0.06545218474500554 0.00936998084530213 0.033805879561430496 1.1613196123872179e-07 6.935048239526161 -0.5401306925705658 LLSHMAAQCLALLLYFQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLSHMAAQCLALLLYFQLR 19 0 Q8NG48;Q8NG48-3;Q8NG48-2;H3BNS6;H0YMK4;H0YKU3;H3BNM9 Q8NG48 LINS Protein Lines homolog 0 16407400.0 5903200.0 8447900.0 2056300.0 False True 4908772.35610135 8402389.48592314 2486262.822743029 1.0 1.7117089317616052 0.5064938119716904 22.22693083272017 -6.7466881265001195 1.6620147039536979 1.4201508025857883 0.5046783904625145 0.6346322222859384 0.29902933760413963 0.3058582405267741 1.661198375840525 0.1421905923006541 0.346421005928598 1.791892177253612e-07 6.7466881265001195 -0.9154724121232738 LLSILLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLSILLSK 8 0 Q02040 Q02040 AKAP17A A-kinase anchor protein 17A 0 4683360.0 1301400.0 2466200.0 915760.0 False True 1706148.002775529 2098252.5731723052 821005.939790202 1.0 1.2298186146564707 0.48120440809039144 20.70231137049903 -6.824295320115603 1.3532138291123779 1.123360321879196 0.46330889775215234 0.8939786232099797 0.1019542728286646 0.1879542618979709 0.6750925180899127 0.05918789386509198 0.13628598120191054 1.4986653969186098e-07 6.824295320115603 -0.6600514241270438 down LLSILLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLSILLSK 8 0 Q02040 Q02040 AKAP17A A-kinase anchor protein 17A 0 14624500.0 3140600.0 6400800.0 5083100.0 False True 4764519.808614852 5258527.230321343 4078423.0569981206 1.0 1.1036846191327117 0.8559987618529401 22.183899388991563 -6.79302104047742 1.4844882782550792 1.0577225911016137 0.8531500829311152 0.8108898874582726 0.04416643228594512 0.23087857800797057 1.0050702106304465 0.02341559849845522 0.054697612615023386 1.6105676053307096e-07 6.79302104047742 -0.20457250817049855 LLSILLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLSILLSK 8 0 Q02040 Q02040 AKAP17A A-kinase anchor protein 17A 0 8209900.0 1301400.0 2517500.0 4391000.0 False True 1782562.7490126188 2406268.525740778 3353936.235483682 1.0 1.3498927468744855 1.8815249209832665 20.76552143202192 -6.965042915393447 0.35732027210060857 0.9527637738262517 2.2967965674209196 0.9999140209980628 0.0033605431400207607 0.0779464618853391 0.014808969191038286 0.0071728139905337844 0.04548195436337234 1.0838198096170047e-07 6.965042915393447 1.344032793594668 LLSILLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLSILLSK 8 0 Q02040 Q02040 AKAP17A A-kinase anchor protein 17A 0 12907500.0 3140600.0 5357700.0 4409200.0 False True 4065568.610481234 5059539.285203193 3606770.8422124856 1.0 1.2444850327109116 0.8871504057056262 21.955025711084012 -6.722562879017422 1.7504766940713723 1.1483341360340689 0.8876393673109213 0.5244619289402825 0.10284876625126192 0.350336074966273 2.099366585755138 0.04663152801420304 0.11669424683606372 1.894249236974135e-07 6.722562879017422 -0.26069476872314756 LLSISGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLSISGKR 8 1 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 1 3254540.0 1383000.0 1262700.0 608840.0 True False 1813126.3929910497 1074310.0819660497 545843.0772056713 1.0 0.5925180319027836 0.3010507592386946 20.790048068143452 -8.052828015271043 0.2280507075160445 1.2121264313949849 1.8232502412566942e-24 0.9997095994628604 0.00488487563258478 0.09598529226520372 0.042780777871002595 0.0780935135089905 0.1014028259657021 8.854661934097616e-09 8.052828015271043 -1.2121264313949849 down LLSISGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLSISGKR 8 1 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 1 4308300.0 1596000.0 1351500.0 1360800.0 True False 1545335.8536062324 1891160.9979793944 1004365.6568750632 1.0 1.2237863979963555 0.6499335756245166 20.559488987826338 -6.800953370196068 1.4521117970833688 1.123323998742785 0.6418329230732558 0.8349086216948585 0.09595424929464995 0.21940100787964345 0.9132696228634265 0.05198281785121321 0.12081820620440523 1.5814178255504093e-07 6.800953370196068 -0.4814910756695292 LLSISGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLSISGKR 8 1 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 1 14149300.0 2857000.0 5184200.0 6108100.0 True False 4334277.8746776525 4259039.005660525 4900831.357724662 1.0 0.9826409678399488 1.130714619465681 22.047360218272257 -6.877671744491953 1.0926502267966185 0.9895381110506997 1.140753113190307 0.971760682911763 0.01110647860531479 0.12971493025730585 0.28488987788764786 0.007845533685013091 0.01886603341211589 1.3253428989062886e-07 6.877671744491953 0.15121500213960737 LLSISGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLSISGKR 8 1 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 1 3165860.0 1383000.0 728460.0 1054400.0 True False 1894332.4741696997 696274.228504917 805372.4360496446 1.0 0.36755650763475367 0.4251484082289438 20.853258129666344 -10.859008517311143 11.2630200473999 1.015588112822076 0.39635245793184926 0.9932194882850351 0.023511794962142854 0.008114740503827749 0.00010158083385774322 0.020072879620004695 0.007588399193985221 1.3835392449641608e-11 10.859008517311143 -0.6192356548902268 LLSISGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLSISGKR 8 1 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 1 5904750.0 1596000.0 3421900.0 886850.0 True False 1327144.714788208 3403465.5455060285 1072286.2346688989 1.0 2.564502203551456 0.8079648155325845 20.339894263260614 -6.671791878026805 1.9312523225573508 1.997073063848543 0.8150378317346822 0.2869685901442045 0.6642926326255506 0.45697889947633125 3.2877041708010375 0.2767626807014354 0.7376548808277728 2.1291591340999722e-07 6.671791878026805 -1.1820352321138607 LLSISGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLSISGKR 8 1 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 1 22444400.0 2857000.0 6206400.0 13381000.0 True False 3698442.8198894756 5861008.384135928 10945795.300654396 1.0 1.5847232658611385 2.9595686167676107 21.818486540364706 -6.956762703604933 0.47888922227709824 0.9666523693819229 3.6348522816294744 0.9996306277983691 0.015786180581432798 0.08087857513961476 0.025563757626441783 0.019341449093273354 0.11341766423628719 1.1046820479363269e-07 6.956762703604933 2.6681999122475517 LLSITVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLSITVR 7 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 21185400.0 3891100.0 6716300.0 10578000.0 False True 5329744.823023661 6419551.658165954 8079694.260748436 1.0 1.204476362627062 1.5159626828371642 22.34563503075682 -6.964999538189924 0.3580629546211966 0.9725582361046589 1.7585229905360313 0.9999131320502974 0.0019772517253972464 0.07796114959782685 0.014860681824160178 0.004195899941219069 0.02663601485807039 1.0839280666230836e-07 6.964999538189924 0.7859647544313725 LLSITVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLSITVR 7 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 42982000.0 13570000.0 12769000.0 16643000.0 False True 17566632.504690308 12058393.925146883 13614144.771600842 1.0 0.6864374217384738 0.7750002607480889 24.06633431973455 -10.11122231948476 7.231405208271856 1.0000001007150607 0.7307188412432816 0.9249627926095191 0.036155627624301745 5.8711149592450247e-08 7.285857216683145e-09 0.03500754895637655 0.011669178638383121 7.740654448835221e-11 10.11122231948476 -0.26928125947177917 LLSK(ub)IHNVGSPLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLSKIHNVGSPLK 13 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 10232200.0 1168400.0 1873200.0 7190600.0 True False 1772548.2214817514 1538912.824621599 5769374.758248066 1.0 0.8681923605639082 3.254847844661281 20.7573934452777 -6.893837759794305 0.9994342847766648 0.8833091795540766 3.476221826487972 0.9832421292253783 0.14179356970330165 0.11608338621289371 0.2041151694924501 0.10752155083111953 0.27202599721464193 1.276915739534136e-07 6.893837759794305 2.5929126469338954 up LLSK(ub)KPEDRPNTSEILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLSKKPEDRPNTSEILR 17 3 P19525-2;P19525 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 1 6303300.0 2041300.0 1990600.0 2271400.0 True False 2676164.0679773227 1693610.239298028 2036377.316807313 1.0 0.6328499285838177 0.7609314171632353 21.351735135528287 -10.422105331212077 5.108222042068596 1.0003385205325064 0.6968906728735115 0.8818988379522272 0.05228904875266656 0.00020181107353225243 2.2830909692597607e-05 0.05068438707336736 0.016876217917334544 3.7835081062307e-11 10.422105331212077 -0.3034478476589949 LLSK(ub)KPEDRPNTSEILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLSKKPEDRPNTSEILR 17 3 P19525-2;P19525 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 1 7295200.0 1321600.0 2293500.0 3680100.0 True False 1279646.5314072664 3209306.5104444977 2716171.4093664866 1.0 2.507963278668153 2.1225950625438963 20.287313928136076 -10.191884169994028 5.277179106532803 0.9999284790790967 2.3152791706064324 0.9395106560080059 0.15732591543329183 0.00013239516351626086 2.027399346840071e-05 0.1523383281654073 0.05077672086645473 6.428591504190848e-11 10.191884169994028 1.3153506915273359 LLSK(ub)KPEDRPNTSEILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLSKKPEDRPNTSEILR 17 3 P19525-2;P19525 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 1 24464200.0 4128300.0 4507900.0 15828000.0 True False 6262932.919157069 3703430.024616539 12699588.862341145 1.0 0.5913251941895277 2.0277382859228177 22.578406995972795 -6.830677447328077 1.3248749964258242 0.7817339290307324 2.0669309660413213 0.907227120300824 0.18405980867382724 0.17997401974337865 0.6175927198202443 0.10907184298383574 0.2510016193749024 1.4768029549669548e-07 6.830677447328077 1.285197037010589 up LLSK(ub)KPEDRPNTSEILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLSKKPEDRPNTSEILR 17 3 P19525-2;P19525 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 1 5957400.0 2041300.0 1331500.0 2584600.0 True False 2796023.7740582903 1272669.9273183125 1974170.7115078855 1.0 0.4551713540944235 0.7060636357331377 21.41494519705118 -10.39383163311996 5.999567336884519 1.0000967971063996 0.5806174949137838 0.7883822526452198 0.10242634506958384 0.00013264637385478065 1.3401959802321396e-05 0.0991965931222669 0.033057960722282606 4.038019081742812e-11 10.39383163311996 -0.41947930219261587 LLSK(ub)KPEDRPNTSEILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLSKKPEDRPNTSEILR 17 3 P19525-2;P19525 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 1 6789500.0 1321600.0 3259300.0 2208600.0 True False 1098968.9568070779 3241741.503979606 2670408.0485873935 1.0 2.949802616261424 2.429921274888367 20.067719203570352 -10.042918525081518 4.934048046340775 0.9999679696169063 2.6898619455914905 0.9337197955053085 0.21224066891701246 73451443.94077486 1.2114059524815757 26729.24013672109 0.07265562623245282 9.059025349299784e-11 10.042918525081518 1.6898939759745844 LLSK(ub)KPEDRPNTSEILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLSKKPEDRPNTSEILR 17 3 P19525-2;P19525 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 1 19703100.0 4128300.0 3730800.0 11844000.0 True False 5344165.730958949 3523177.700363226 9688513.529702611 1.0 0.6592568190678159 1.8129141230738215 22.349533318065244 -6.827601541971887 1.3386528310438126 0.8176076633700806 1.842451643822322 0.9009804003369644 0.15228609727733652 0.183789951191563 0.6449714913014062 0.08934318284248821 0.20562847569600168 1.4872995893480143e-07 6.827601541971887 1.0248439804522413 LLSLISIALPENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLSLISIALPENK 13 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 6160380.0 2378700.0 2919700.0 861980.0 False True 3118498.7353635696 2484092.140901463 772790.5782960135 1.0 0.7965666661114922 0.2478085270751017 21.57242024318948 -6.953812848957638 0.5152901216893747 1.009675983517429 0.010406245518653535 0.9994675179736234 0.007330755979911992 0.08198990540735736 0.029898720401557076 0.008368490981324295 0.04530828475213588 1.112210910409285e-07 6.953812848957638 -0.9992697379987754 down LLSLISIALPENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLSLISIALPENK 13 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 10592300.0 4148900.0 4111000.0 2332400.0 False True 4017195.440493038 5752543.738581791 1721474.4694998483 1.0 1.4319800526995943 0.42852644214107954 21.937757220941844 -6.789715145180518 1.4974213222611537 1.2415259126468567 0.41793205815084616 0.8004020557525524 0.18360901090766374 0.23578436656636675 1.04444871387068 0.09651394748284599 0.2260145873133461 1.6228741955272268e-07 6.789715145180518 -0.8235938544960106 down LLSLISIALPENK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLSLISIALPENK 13 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 7563000.0 2123400.0 5439600.0 0.0 False True 3221353.0413337518 4468860.88021122 0.0 1.0 1.387262067482351 0.0 21.61923534959491 -6.860663706554971 1.382116494030897 1.204389305347727 2.271184724831715e-20 0.9092886099356842 0.1760332233265556 0.1648456353819124 0.6330779513602648 0.1027214178747281 0.21416604623925414 1.378276316159679e-07 6.860663706554971 -1.204389305347727 down LLSLISIALPENK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLSLISIALPENK 13 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 24347000.0 2378700.0 4696300.0 17272000.0 False True 3258169.6719504497 4488801.937412679 13192709.328005947 1.0 1.3777066234630844 4.049116730040749 21.63563030471237 -6.932462288242997 0.7262943137191061 0.9628562742721593 4.633597911057551 0.9970004757137046 0.07432715626431671 0.0913792509407254 0.07156297716004588 0.06873605238417636 0.23852806103747243 1.1682551703450529e-07 6.932462288242997 3.670741636785392 up LLSLISIALPENK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLSLISIALPENK 13 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 9344500.0 4148900.0 2096700.0 3098900.0 False True 3449994.1774340784 2085404.6609376334 3746865.6623052917 1.0 0.6044661392700222 1.0860498509861285 21.71816249637612 -6.688456380804809 1.8717568460447853 0.7516674279775154 1.0843609998545376 0.3632440402669489 0.167335909939437 0.4200120850215539 2.851726425435033 0.07154900738260425 0.1866918124247799 2.049007835635831e-07 6.688456380804809 0.3326935718770222 LLSLISIALPENK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLSLISIALPENK 13 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 9175900.0 2123400.0 2821600.0 4230900.0 False True 2748783.1584715834 2664575.4796142615 3460919.612699991 1.0 0.9693654704636127 1.259073347431443 21.39036167168736 -6.88075816859481 1.0755145430052844 0.9808139702145998 1.279909529039377 0.9742938618891556 0.020835406590856618 0.12696276556414857 0.26822008844155326 0.014912255753413659 0.03613355332657084 1.3159574024955668e-07 6.88075816859481 0.2990955588247771 LLSLPCTLNLQLMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLSLPCTLNLQLMR 14 0 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;Q86UV5-7;Q86UV5-4 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 0 33056400.0 7784400.0 14302000.0 10970000.0 False True 11809503.915870026 11749696.357963962 8801774.691678192 1.0 0.994935641807469 0.7453128221457346 23.49344502664803 -6.911286496625803 0.886930927885576 1.0074178840954453 0.7121498278224591 0.9913980113063928 0.01102621317078368 0.10357334583396524 0.13419913532180117 0.009085129022659308 0.025308252312189188 1.226629777556894e-07 6.911286496625803 -0.29526805627298625 LLSLPCTLNLQLMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLSLPCTLNLQLMR 14 0 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;Q86UV5-7;Q86UV5-4 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 0 22299500.0 7784400.0 6492000.0 8023100.0 False True 10077059.25346433 6130714.493073348 6562978.123957868 1.0 0.6083832930689286 0.6512791042388306 23.26457134874048 -10.298849150876539 8.60751752392101 1.0000003413748275 0.629831198933125 0.9900289851137458 0.017512141578173192 1.1471801585530643e-07 9.349262265879682e-09 0.016956073962961355 0.0056520193907242675 5.0251710498241494e-11 10.298849150876539 -0.3701691424417025 LLSLSGVFAVHKPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLSLSGVFAVHKPK 14 1 Q8WWH5 Q8WWH5 TRUB1 Probable tRNA pseudouridine synthase 1 0 32856500.0 10823000.0 8583500.0 13450000.0 False True 16419282.267286051 7051707.361808403 10791601.604655577 1.0 0.42947719924751515 0.6572517256833373 23.968887728473515 -10.248023954760221 5.567129512152231 1.000029731832225 0.5433644624654147 0.8427377138171919 0.0929885610286973 3.43173458619101e-05 4.635375298172387e-06 0.09004163693082669 0.030011929020986455 5.649058149493097e-11 10.248023954760221 -0.4566652693668104 LLSLSGVFAVHKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLSLSGVFAVHKPK 14 1 Q8WWH5 Q8WWH5 TRUB1 Probable tRNA pseudouridine synthase 1 0 9864400.0 2765100.0 3287600.0 3811700.0 False True 3787432.1940178154 3142342.9613606343 2911454.964425679 1.0 0.8296763612887674 0.7687147426755976 21.852788629730252 -13.999999999999998 0.14305973540785297 1.816073838429404 0.6959818891072337 0.9995910190088262 0.0019793873242803695 11.938346997185832 0.1187175485958653 2.715412830789677 0.06516503584810208 1.0000000000000041e-14 13.999999999999998 -1.1200919493221702 LLSLSGVFAVHKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLSLSGVFAVHKPK 14 1 Q8WWH5 Q8WWH5 TRUB1 Probable tRNA pseudouridine synthase 1 0 9954700.0 5171800.0 3241700.0 1541200.0 False True 4300580.849587504 3224236.3186729304 1863457.794296336 1.0 0.7497211263874245 0.433303746510212 22.036100097098487 -6.9679425354239966 0.3033309977413223 1.0527496694684628 0.12031328333707308 0.999961593657075 0.0014369987031557564 0.07697611006202512 0.011407064152288452 0.005164673298191194 0.028279534146437905 1.0766076577830941e-07 6.9679425354239966 -0.9324363861313898 down LLSLSGVFAVHKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLSLSGVFAVHKPK 14 1 Q8WWH5 Q8WWH5 TRUB1 Probable tRNA pseudouridine synthase 1 0 33773000.0 10823000.0 12699000.0 10251000.0 False True 14010586.853224995 11992289.486681843 8385423.184142293 1.0 0.855944837451361 0.598506206198787 23.740014050565964 -6.962184948168536 0.4034605236068952 1.0136227363758121 0.4313754467708809 0.9998428476804749 0.002081896752492843 0.07892964784010856 0.018313816480723197 0.003311829833878768 0.021541974046854907 1.090975635827662e-07 6.962184948168536 -0.5822472896049312 LLSLYGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLSLYGK 7 0 Q92523-4 Q92523-4 0 74050000.0 16884000.0 24516000.0 32650000.0 False True 22135087.504888598 20858308.362619508 29271691.200915158 1.0 0.9423187668904806 1.3224113613488278 24.39983174095065 -6.868213857743769 1.1434187361259927 0.9677008687962474 1.3439365523324136 0.9628722233352982 0.03222626760842752 0.13858346286790865 0.33973582631718086 0.02189492259570606 0.05168554430377462 1.3545222465982054e-07 6.868213857743769 0.3762356835361662 LLSLYGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLSLYGK 7 0 Q92523-4 Q92523-4 0 29283700.0 9819000.0 4019700.0 15445000.0 False True 9507301.21964887 5624787.172458571 11399491.159931894 1.0 0.5916281647660165 1.1990249279545713 23.18060443936991 -6.725574032046642 1.7393507006387365 0.7530369044731483 1.1983812970258325 0.5386029374351586 0.17173818042808792 0.34461650343004707 2.040377168850232 0.07831217168217773 0.19530893142665026 1.8811610066104374e-07 6.725574032046642 0.4453443925526842 LLSLYGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLSLYGK 7 0 Q92523-4 Q92523-4 0 21034100.0 6283000.0 8184000.0 6567100.0 False True 9531770.348827317 6723501.258116148 5269109.806537819 1.0 0.705378016051691 0.5527944561931322 23.184312762081987 -13.999999999992939 0.08360597298751976 2.5562187679922577 0.12605323491594345 0.9998713704278809 0.0021051452164447463 12.22321955995821 0.0823846626487719 3.463168578955409 0.38590281961112816 1.0000000000162586e-14 13.999999999992939 -2.4301655330763143 LLSLYGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLSLYGK 7 0 Q92523-4 Q92523-4 0 57468000.0 16884000.0 15464000.0 25120000.0 False True 23126471.072943784 14780749.347390449 19187173.362639487 1.0 0.6391268819514276 0.829662826728762 24.46304180247354 -10.048467984378672 4.8805549838258475 1.0000058963581826 0.7343948543377965 0.7215216210795523 0.07778597373820344 5.102873339627077e-06 9.948189740110978e-07 0.07531765413680883 0.025105315069823067 8.94400463534999e-11 10.048467984378672 -0.2656110420203861 LLSLYGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLSLYGK 7 0 Q92523-4 Q92523-4 0 23600500.0 9819000.0 7000300.0 6781200.0 False True 8164933.5554545205 6962587.99444925 8199117.567273765 1.0 0.8527427623459284 1.0041866858544621 22.961009714804188 -11.057948950909799 9.663425260219446 1.259720132690892 0.9284647240982347 0.22928244001469034 0.06182672287349894 0.04813617561947667 0.00028865993206504616 0.008329513607681705 0.019954489003303544 8.75086631130116e-12 11.057948950909799 -0.33125540859265734 LLSLYGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLSLYGK 7 0 Q92523-4 Q92523-4 0 15282500.0 6283000.0 6844800.0 2154700.0 False True 8133467.356445761 6463880.862937234 1762566.7090890051 1.0 0.7947263546603673 0.21670545068238006 22.955439084174436 -6.9934476052373595 0.5418458342831849 1.0078077739888378 3.323018213210629e-13 0.9993944339803454 0.008160789684816885 0.07669492056618968 0.032107270786977726 0.009127311601867073 0.044186415634392406 1.0152018365855932e-07 6.9934476052373595 -1.0078077739885054 down LLSPVVPQISAPQSNK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLSPVVPQISAPQSNKER 18 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BVE2;H3BRD9 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 85612300.0 5503300.0 19787000.0 60322000.0 True False 8348908.445121976 16255855.253463378 48399330.2599282 1.0 1.9470635425354559 5.797084801930787 22.99315615807852 -6.944503101883914 0.6162469315014458 0.9577319119389237 6.989074750913496 0.9986962188341644 0.07490553362220351 0.08577100349858495 0.045696295827589745 0.07569606214660099 0.3253737244173027 1.136310181711414e-07 6.944503101883914 6.031342838974573 LLSPVVPQISAPQSNK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLSPVVPQISAPQSNKER 18 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BVE2;H3BRD9 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 84521300.0 5503300.0 12301000.0 66717000.0 True False 7124130.336261014 11616438.53655196 54575190.57422908 1.0 1.6305763634651105 7.6606109094393675 22.76428248017097 -6.926935452855018 0.771527451577431 0.897133306464402 8.807191973602782 0.9959010171811832 0.19221529444696095 0.09426046949810743 0.08570523279838421 0.17202508163829505 0.5550912007627854 1.1832173986910317e-07 6.926935452855018 7.9100586671383795 up LLSSFDFFLTDAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLSSFDFFLTDAR 13 0 O76021;J3QSV6;I3L3U9;I3L3C4;I3L234 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 51548000.0 15058000.0 19233000.0 17257000.0 False True 22844086.887258 15800720.88188512 13846146.385988189 1.0 0.6916766233584265 0.6061151165429732 24.445317441205155 -13.999999999999998 0.1798536757470648 2.5990329032268042 0.5380463995352953 0.9994983144031621 0.0037888503031757365 12.202821611812167 0.134438432937427 6.818585477625776 0.0639626952766133 1.0000000000000041e-14 13.999999999999998 -2.0609865036915087 LLSSFDFFLTDAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLSSFDFFLTDAR 13 0 O76021;J3QSV6;I3L3U9;I3L3C4;I3L234 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 35514400.0 15058000.0 8551400.0 11905000.0 False True 19492877.83755539 8075507.072715271 9738412.155615466 1.0 0.4142798790416071 0.4995882207219929 24.216443763297605 -10.72465567685008 6.900519970649956 1.0068364956281528 0.45693404988223524 0.9818291579656803 0.034826984653324594 0.0036657886447461355 0.00014627200877655435 0.03374704911290818 0.011240360963412289 1.8851431014847572e-11 10.72465567685008 -0.5499024457459176 LLSSLTGSWSLVHNGVSYYINLCQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLSSLTGSWSLVHNGVSYYINLCQK 25 0 P11717 P11717 IGF2R Cation-independent mannose-6-phosphate receptor 0 54856000.0 10369000.0 14047000.0 30440000.0 False True 15730531.07544016 11540203.100288067 24423520.657674033 1.0 0.7336181496316809 1.552618951041399 23.90706404233769 -6.819118739011509 1.3755562813462803 0.856283834947523 1.5701783319259335 0.8823463482846483 0.11699773671247411 0.19464806394472567 0.723916019218683 0.0668393762550058 0.15410091411939464 1.5166356524537354e-07 6.819118739011509 0.7138944969784105 LLSTK(ub)PSSIISTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLSTKPSSIISTK 13 1 Q8NCD3;C9JWC4;Q8NCD3-3;Q8NCD3-2;H7C3V8 Q8NCD3 HJURP Holliday junction recognition protein 1 11825200.0 2852100.0 3306400.0 5666700.0 True False 2761561.646660612 4626662.762648215 4182421.272643969 1.0 1.6753791349336544 1.5145130935974274 21.397052902541176 -10.14723539529382 4.732672652653402 0.9999452200233461 1.5949461142704116 0.9480181872354665 0.06567328638592554 8166799.1058815 17625968.78881164 2979.422708453365 0.02248171521410637 7.12466755863806e-11 10.14723539529382 0.5950008942470655 LLSTK(ub)PSSIISTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLSTKPSSIISTK 13 1 Q8NCD3;C9JWC4;Q8NCD3-3;Q8NCD3-2;H7C3V8 Q8NCD3 HJURP Holliday junction recognition protein 1 9851200.0 2852100.0 4915400.0 2083700.0 True False 2371647.519453289 4888919.764569492 2519392.036059742 1.0 2.0614023477217573 1.0622961529462485 21.177458177975453 -6.631981743174362 2.0737206436927633 1.6982886975997646 1.0663877348297708 0.12444884109851262 0.45506514305357126 0.5539151165621667 4.542110699728838 0.1793412581073062 0.5039210010211107 2.3335561580068396e-07 6.631981743174362 -0.6319009627699939 LLSTK(ub)PSSIISTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLSTKPSSIISTK 13 1 Q8NCD3;C9JWC4;Q8NCD3-3;Q8NCD3-2;H7C3V8 Q8NCD3 HJURP Holliday junction recognition protein 1 10696000.0 2407300.0 2330000.0 5958700.0 True False 3116297.3049772205 2200333.4517653915 4874277.741425098 1.0 0.7060730207772893 1.5641247494711445 21.571401447125364 -6.814235670348111 1.396480217233415 0.8405857862635062 1.580657942337982 0.8706137548799886 0.12806878002275465 0.20109913590520948 0.7720691614473132 0.07209021656470128 0.16647669522760988 1.53378444722085e-07 6.814235670348111 0.7400721560744759 LLSVNIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLSVNIR 7 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 163476000.0 49703000.0 64166000.0 49607000.0 False True 65161114.32453668 54592682.917108975 44474143.50394478 1.0 0.8378107631064848 0.6825258279414945 25.95750793990948 -6.971654620457406 0.21502628685681577 1.0762640530624605 0.4397128101972925 0.9999925702846119 0.0003532605169676629 0.07576939216086614 0.007076536679223984 0.004469764795266756 0.015909320205923484 1.067444686005711e-07 6.971654620457406 -0.6365512428651681 LLSVNIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLSVNIR 7 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 129006000.0 50686000.0 32443000.0 45877000.0 False True 49077000.674113736 45397659.08800991 33860437.41950123 1.0 0.9250292084771892 0.689945126116098 25.5485437460403 -6.950452951700744 0.5538573608762669 1.0031792601429248 0.6006780193573555 0.9992362906182533 0.003650216334683004 0.08330454413103013 0.03521483521991582 0.003942508638619474 0.01951679886933323 1.1208488441553659e-07 6.950452951700744 -0.40250124078556926 LLSVNIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLSVNIR 7 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 337023000.0 106680000.0 138820000.0 91523000.0 False True 161841359.35268155 114046486.39438939 73433438.93404405 1.0 0.7046807246957282 0.4537371610554711 27.27000510177417 -7.139945823129708 0.18486963059908657 1.1933110094736294 3.4644165942250163e-13 0.9999941961561503 0.0005378188334443324 0.08176441281854242 0.00731663810023918 0.012393171449028345 0.032359103368384844 7.24526336818865e-08 7.139945823129708 -1.193311009473283 down LLSVNIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLSVNIR 7 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 213922000.0 49703000.0 92877000.0 71342000.0 False True 68079542.27307062 88773387.03683285 54492488.93461104 1.0 1.303965685914252 0.8004238441562783 26.02071800143237 -6.74327042618123 1.6747976682895434 1.1801696005985958 0.7999170121935514 0.6195143555011431 0.12770791985193913 0.31192445956720627 1.7191446369175263 0.060294780558571896 0.14742587297668241 1.806049186377287e-07 6.74327042618123 -0.3802525884050444 LLSVNIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLSVNIR 7 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 93327000.0 50686000.0 27328000.0 15313000.0 False True 42147654.77052327 27180778.639816742 18514877.50068763 1.0 0.6448942126864462 0.4392860670776004 25.328949021474575 -9.734253946785126 0.12162624716666756 1.7011310563076754 5.914087111154692e-16 0.9998821710962714 0.002514061399178959 1.2329317554633659 0.051995919746084564 0.5051070700641951 0.2259369272697867 1.8439368911391334e-10 9.734253946785126 -1.7011310563076747 LLSVNIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLSVNIR 7 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 341900000.0 106680000.0 129270000.0 105950000.0 False True 138099362.97718185 122076010.86253719 86668187.13880372 1.0 0.8839722952430114 0.6275784715467797 27.04113142386662 -6.958048816819072 0.4621189835853009 1.007317366744199 0.4938609918545847 0.999690822464893 0.002735951420353158 0.08040573396185303 0.02376413302083473 0.0034948288797409144 0.021175961556518432 1.1014154981062759e-07 6.958048816819072 -0.5134563748896144 LLSWLGSIIGYSDGLRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLSWLGSIIGYSDGLRR 17 1 Q8IWV8-4;Q8IWV8;Q8IWV8-2 Q8IWV8-4 UBR2 E3 ubiquitin-protein ligase UBR2 0 12011000.0 2913600.0 3478300.0 5619100.0 False True 4420144.212691919 2857570.1889180555 4508482.422060977 1.0 0.6464879993537048 1.0199853681505244 22.07566200942536 -11.028014513122695 12.515975851430401 1.3738776400356216 0.8332366837520221 0.2099894895054797 0.15247966230405258 0.04519724932476902 0.00010116511902118372 0.004194715295078033 0.049212599394910544 9.375306762835308e-12 11.028014513122695 -0.5406409562835995 LLSWLGSIIGYSDGLRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLSWLGSIIGYSDGLRR 17 1 Q8IWV8-4;Q8IWV8;Q8IWV8-2 Q8IWV8-4 UBR2 E3 ubiquitin-protein ligase UBR2 0 11823700.0 2913600.0 3572900.0 5337200.0 False True 3771712.6356422757 3374064.974168481 4365884.364296585 1.0 0.8945710609774278 1.1575336686680346 21.84678833151781 -6.797884073891472 1.464442835632016 0.9416730700045709 1.1609806715340876 0.8259307193231367 0.04508196527645103 0.22379164755150027 0.9477139327769006 0.024220035931983276 0.056403363088373536 1.5926337916244677e-07 6.797884073891472 0.21930760152951667 LLTASGAQDSLPFGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLTASGAQDSLPFGR 15 0 P49796 P49796 RGS3 Regulator of G-protein signaling 3 0 16211500.0 3259100.0 3212200.0 9740200.0 False True 4218969.196465444 3033438.246249262 7967583.542891707 1.0 0.7189998563607923 1.888514272530543 22.008459123516 -6.843274763206591 1.2671625968036742 0.8505222747635443 1.9295266790432979 0.9299294089371227 0.13194722877436085 0.16500928354150113 0.5132670493927242 0.0816040688151464 0.18819134359750309 1.4345815357068288e-07 6.843274763206591 1.0790044042797535 LLTDDGNK(ub)WLYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLTDDGNKWLYK 12 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 82334000.0 17341000.0 25550000.0 39443000.0 True False 22734218.93048289 21738039.593119964 35361816.72397235 1.0 0.9561815015325988 1.5554445407648425 24.43836210310921 -6.889306275025864 1.0264464836469076 0.9672634349179254 1.6062975723228579 0.9804516460399497 0.03813527918847417 0.11970912971944234 0.22513449626704196 0.02833311645266099 0.07046290445942832 1.2903089954065347e-07 6.889306275025864 0.6390341374049324 LLTDDGNK(ub)WLYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLTDDGNKWLYK 12 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 111049700.0 17894000.0 27201700.0 65954000.0 True False 17325964.76468037 38063480.664991565 48678668.82241167 1.0 2.1969039636156595 2.8095791191752255 24.046432352647194 -9.221803240274356 0.21004914275647907 1.1288708883018384e-18 3.3776291154210405 0.9994531343619594 0.017573524326997728 0.6575379818198733 0.07640517501798615 0.7660221062944953 0.323606035900231 6.000628767738325e-10 9.221803240274356 3.3776291154210405 LLTDDGNK(ub)WLYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLTDDGNKWLYK 12 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 374549000.0 55419000.0 207059000.0 112071000.0 True False 84074674.67159972 170107703.69064903 89920117.72753578 1.0 2.0232930350917093 1.0695267995834499 26.32516795544091 -6.629504377222247 2.081904265411272 1.6743892951960222 1.0733294340459485 0.11583455013669819 0.43898972510025835 0.5602930160577356 4.627112621772038 0.17248426247523221 0.4864171627768041 2.3469056082776743e-07 6.629504377222247 -0.6010598611500737 LLTDDGNK(ub)WLYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLTDDGNKWLYK 12 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 91543000.0 17341000.0 22556000.0 51646000.0 True False 23752436.322904415 21559401.337282613 39448278.482757926 1.0 0.9076711560949617 1.6608097774255708 24.5015721646321 -6.876228248279142 1.1006723614145264 0.9451954377499456 1.7104583238950475 0.9705111116837755 0.057595237974525176 0.13102094615918702 0.2929528287577241 0.040437762329819084 0.09691363909802123 1.3297553666237476e-07 6.876228248279142 0.7652628861451019 LLTDDGNK(ub)WLYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLTDDGNKWLYK 12 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 86917700.0 17894000.0 38297800.0 30725900.0 True False 14879653.838609116 38091482.14988188 37150543.629489906 1.0 2.55997098877688 2.4967344020526334 23.82683762808147 -10.472037172366665 5.128239873557296 0.9970028839280032 2.5283526954147946 0.9987176880400791 0.02581622842507484 0.0008852541537324476 9.1138596528906e-05 0.025013817725047394 0.008332151895997895 3.372584406177653e-11 10.472037172366665 1.5313498114867914 LLTDDGNK(ub)WLYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLTDDGNKWLYK 12 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 326308000.0 55419000.0 175537000.0 95352000.0 True False 71740987.97180766 165768211.6405756 77998914.39414068 1.0 2.3106485752010855 1.0872294430178773 26.09629427753336 -6.6298587107611056 2.081405571519856 1.863512679112103 1.0921639097286193 0.11715341225538656 0.5622055418721122 0.5590907831417287 4.615764058230288 0.22096074995701356 0.6226499947553277 2.3449915885114194e-07 6.6298587107611056 -0.7713487693834837 LLTFNPTYCALK(ub)ELNDEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLTFNPTYCALKELNDEER 19 1 Q14139-2;Q14139 Q14139-2 UBE4A Ubiquitin conjugation factor E4 A 1 32846800.0 4957800.0 10519000.0 17370000.0 True False 7521345.063730076 8641802.26467788 13936811.886458548 1.0 1.1489703226555774 1.8529680221248666 22.842559255595255 -6.941071821419225 0.6495229618680343 0.992220789661733 2.0489486291161314 0.9983008609694944 0.015333472477648904 0.08728117482607657 0.052409803967936805 0.015050042202671317 0.06031131508751516 1.1453235179872488e-07 6.941071821419225 1.0567278394543984 LLTFNPTYCALK(ub)ELNDEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLTFNPTYCALKELNDEER 19 1 Q14139-2;Q14139 Q14139-2 UBE4A Ubiquitin conjugation factor E4 A 1 21827100.0 4957800.0 6617300.0 10252000.0 True False 6417969.832848446 6249041.437925807 8386241.194403168 1.0 0.973678842480993 1.3066813046519348 22.613685577687704 -6.887781518206653 1.0353872227100904 0.9811443229154975 1.3341111026587391 0.9794410342763473 0.021673539886775065 0.1209628165339624 0.2324948396568909 0.015993875310866372 0.03956855429914503 1.2948470801281171e-07 6.887781518206653 0.35296677974324164 LLTHNLLSSHVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLTHNLLSSHVR 12 0 F5GX77;Q9UI30;Q9UI30-2 F5GX77 TRMT112 Multifunctional methyltransferase subunit TRM112-like protein 0 6815800.0 1681900.0 1667700.0 3466200.0 False True 2303743.881638479 1594015.4996535853 2647554.9486298203 1.0 0.6919239210392965 1.1492401432865942 21.13554890362659 -6.725214545471812 1.7404551482423747 0.8136207448020505 1.1487495035826283 0.5370163575615563 0.12956404298558424 0.3452978636893571 2.046791142503595 0.0590450961483559 0.14732939864420388 1.8827187793101106e-07 6.725214545471812 0.3351287587805778 LLTK(ub)GLSWQPPPYTPTPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLTKGLSWQPPPYTPTPR 18 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 13729900.0 3952900.0 4625800.0 5151200.0 True False 3827417.3532080627 6472906.063228327 3801946.1873124773 1.0 1.6911942090148255 0.9933450774908997 21.86793979475552 -10.396341891747847 5.327293887259994 0.999791788730543 1.3422696432528696 0.24284840594674473 0.2848957149463581 0.0007049522199881439 7.988139239297596e-05 0.27601508119475143 0.09194969661608826 4.014746315934325e-11 10.396341891747847 0.3424778545223266 LLTK(ub)GLSWQPPPYTPTPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLTKGLSWQPPPYTPTPR 18 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 28820400.0 10794000.0 11608000.0 6418400.0 True False 16375287.14710203 9536461.706282051 5149800.42671535 1.0 0.582369128590807 0.3144861143779528 23.96501686930852 -8.439189111225676 0.20002439730501634 1.3068636032351288 1.424350830758725e-24 0.9997255114590388 0.004673359843233964 0.1330486150226943 0.048890887163389074 0.14008197003629203 0.12401564627755958 3.637566057537556e-09 8.439189111225676 -1.3068636032351288 down LLTK(ub)GLSWQPPPYTPTPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLTKGLSWQPPPYTPTPR 18 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 11433600.0 3304000.0 4420000.0 3709600.0 True False 4525578.087242731 4224709.785014596 2833468.8816101714 1.0 0.9335182607772783 0.6261009813525282 22.109670659935297 -6.9415632027745495 0.6448615105559967 1.0033791395763414 0.5392449374238075 0.9983615038903576 0.006592510909911356 0.08706081458929558 0.051416967912583336 0.006496010790261842 0.026281954691124206 1.1440283775190943e-07 6.9415632027745495 -0.46413420215253387 LLTK(ub)GLSWQPPPYTPTPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLTKGLSWQPPPYTPTPR 18 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 12971300.0 3952900.0 5335400.0 3683000.0 True False 3287011.4931618427 5306657.141206024 4453098.271732033 1.0 1.6144321832295887 1.3547559176461863 21.648345070189798 -10.128877055974462 4.630346135343536 0.9999564337408103 1.484594050444308 0.8227999366687049 0.10601239152853352 4.908936913342328e-05 9.23544106774093e-06 0.10265553333730151 0.034215352235865505 7.432295082765994e-11 10.128877055974462 0.4846376167034977 LLTK(ub)GLSWQPPPYTPTPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLTKGLSWQPPPYTPTPR 18 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 25859500.0 10794000.0 10165000.0 4900500.0 True False 13973045.781549504 9599308.814246867 4008659.28337619 1.0 0.6869875733837592 0.2868851463057083 23.73614319140097 -7.187506953696248 0.34600499753810016 1.0474401255408126 3.527543684762571e-12 0.9998544165375557 0.0035214067370381067 0.08736251333086993 0.01937063905103113 0.008606876931177688 0.04083225301315844 6.493712341001836e-08 7.187506953696248 -1.047440125537285 down LLTLIK(ub)EL ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLTLIKEL 8 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WYT6 P52701 MSH6 DNA mismatch repair protein Msh6 1 1781280.0 700180.0 571190.0 509910.0 True False 917942.7605527645 485970.67848118127 457149.40460210224 1.0 0.5294128341821015 0.49801515328343254 19.808044669860998 -13.999999999999998 0.3846699210315836 8.19203058651712 0.4954792989465781 0.9998149376477331 0.003123357429529373 24.635742413658292 0.20273337185510884 147.00642028199553 0.008392641272930932 1.0000000000000041e-14 13.999999999999998 -7.696551287570542 LLTLIK(ub)EL ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLTLIKEL 8 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WYT6 P52701 MSH6 DNA mismatch repair protein Msh6 1 1947780.0 700180.0 732280.0 515320.0 True False 959055.46765303 699925.4482738662 393612.029348543 1.0 0.7298070569231011 0.4104163342207702 19.87125473138389 -6.968912935983193 0.2829468451017032 1.0679130259237397 0.06253843231985313 0.9999726182411236 0.0012609543250648285 0.07665700717873665 0.01028686127146107 0.005801165464437358 0.02920858922118115 1.0742047390594854e-07 6.968912935983193 -1.0053745936038865 down LLTQDLVQEK(ub)YLEYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLTQDLVQEKYLEYR 15 1 P43355 P43355 MAGEA1 Melanoma-associated antigen 1 1 27724400.0 6911000.0 4802400.0 16011000.0 True False 6691614.087890133 6720023.364185149 11817238.780295867 1.0 1.0042455042866905 1.7659773299960047 22.67392281542652 -6.908123212881309 0.9084231391085144 0.9749923423908179 1.8605656995442343 0.9901936996346747 0.03565841621502283 0.1056723550086 0.14559738515955586 0.028925726498159332 0.0788467312578317 1.235596834828568e-07 6.908123212881309 0.8855733571534165 LLTQDLVQEK(ub)YLEYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLTQDLVQEKYLEYR 15 1 P43355 P43355 MAGEA1 Melanoma-associated antigen 1 1 96927000.0 10717000.0 22822000.0 63388000.0 True False 16258472.51764803 18749235.790900122 50859334.01605267 1.0 1.1531978647162857 3.1281741849270626 23.954688386893277 -6.9223856428703465 0.8068336761183723 0.960055977700035 3.4648167407596437 0.9948183932869028 0.06976211664364615 0.09678838169201284 0.09848846977724313 0.06087936125280541 0.18673838809565427 1.1956783266819407e-07 6.9223856428703465 2.5047607630596085 up LLTQDLVQEK(ub)YLEYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLTQDLVQEKYLEYR 15 1 P43355 P43355 MAGEA1 Melanoma-associated antigen 1 1 28634100.0 6911000.0 6271100.0 15452000.0 True False 5746802.709211335 6237316.339584117 18682941.75802426 1.0 1.0853541795660666 3.2510149910102313 22.454328090860795 -6.915209855326306 0.8594925025630983 0.9434818564015633 3.564481744208461 0.9927437639958607 0.08872747599603553 0.10107301072277336 0.12082233974027991 0.0745682207561732 0.2140914743352125 1.2155984696796385e-07 6.915209855326306 2.6209998878068976 up LLTQDLVQEK(ub)YLEYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLTQDLVQEKYLEYR 15 1 P43355 P43355 MAGEA1 Melanoma-associated antigen 1 1 125930000.0 10717000.0 22434000.0 92779000.0 True False 13873367.763652619 21185528.178929094 75894173.99293122 1.0 1.5270645556181313 5.470493919419432 23.725814708985727 -6.931364148982654 0.7355087695246996 0.9429641836722232 6.308918900544403 0.9967996096624517 0.11285092083356074 0.09193572331925429 0.07425541769823729 0.10365960926535445 0.35417388171850994 1.1712129104108952e-07 6.931364148982654 5.36595471687218 up LLTQYILNLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLTQYILNLGK 11 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 8022300.0 1361700.0 5303400.0 1357200.0 False True 1785201.886721559 4512153.392491289 1216769.9631816878 1.0 2.5275311582700883 0.6815867562274593 20.767655805764647 -6.686933908413354 1.8771086026312784 1.9603781578263757 0.6881519317685537 0.35624443947255124 0.6464415749357563 0.4232699018074607 2.8890640264962397 0.2757373960581014 0.7208803891751312 2.056203488310971e-07 6.686933908413354 -1.272226226057822 LLTQYILNLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLTQYILNLGK 11 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 10710900.0 5916400.0 1169500.0 3625000.0 False True 5728587.1204736205 1636487.44886193 2675503.7523310566 1.0 0.285670343218352 0.4670442634570346 22.449747930709172 -10.7842461957664 10.577205128205836 1.0032573437784815 0.37635730334402695 0.9403476305389205 0.07404559287217122 0.005681632783396718 0.00011589371837592995 0.07161798636474603 0.02389811233783114 1.6434398149206038e-11 10.7842461957664 -0.6269000404344546 LLTQYILNLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLTQYILNLGK 11 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 11364900.0 1361700.0 3120500.0 6882700.0 False True 1865157.2885588459 2982625.9918864374 5257148.013656011 1.0 1.5991284006889457 2.818608406864206 20.83086586728754 -6.959699930923923 0.43964177447673686 0.9562333757178231 3.5090209658110325 0.9997589095220247 0.011749424957275984 0.07980847756572773 0.02152864140948514 0.01607099100951712 0.10104843247362412 1.0972360526311764e-07 6.959699930923923 2.5527875900932093 LLTQYILNLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLTQYILNLGK 11 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 10694100.0 5916400.0 2089300.0 2688400.0 False True 4919748.74096049 2078044.5262064182 3250532.010242841 1.0 0.42238834453174096 0.6607109796441016 22.23015320614345 -10.296904265327004 5.705656678699577 1.0000446343714027 0.5415496620879238 0.8314775440846841 0.09729480836347895 5.524701747643483e-05 6.8077699735977695e-06 0.09421443298259105 0.03140176437201419 5.047725559648133e-11 10.296904265327004 -0.4584949722834789 LLTSFLPAQLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLTSFLPAQLLR 12 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;H0YFX4 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 10281700.0 2014900.0 3378900.0 4887900.0 False True 3056750.608921247 2775908.895533803 3921804.4225573265 1.0 0.9081240999616401 1.2829978380020228 21.543567421205758 -6.841900342994351 1.2735579881846528 0.9511304764389523 1.2957975840896112 0.9276709008286687 0.04290512902394047 0.16658987331053288 0.5240461774674313 0.026408235475789063 0.06087337915698536 1.4391287754299243e-07 6.841900342994351 0.3446671076506589 LLTSFLPAQLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLTSFLPAQLLR 12 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;H0YFX4 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 100015000.0 10425000.0 21278000.0 68312000.0 False True 14279404.22503191 20337867.60306351 52178112.52980213 1.0 1.4242798426709613 3.6540819005833227 23.76743245173524 -6.9386996720764875 0.6715502190058741 0.9743195449408623 4.233066784427555 0.9979885959858491 0.052208394173844944 0.08836486643204354 0.05734854123924986 0.05033361619090605 0.1930400285024672 1.1515964778557217e-07 6.9386996720764875 3.2587472394866928 up LLTSFLPAQLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLTSFLPAQLLR 12 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;H0YFX4 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 10474500.0 2014900.0 5203600.0 3256000.0 False True 2608327.769616838 4914015.0856679715 2663441.4093812634 1.0 1.8839714635978582 1.0211298750128024 21.314693743298207 -10.218721625128165 3.7176492831918737 0.9994751990913867 1.4525506676108542 0.26835577823574785 0.35225360524382543 83251901.07708704 147510790.1786035 549162.5661625735 0.12891160759652043 6.043358735691424e-11 10.218721625128165 0.45307546851946745 LLTSGYLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLTSGYLQR 9 0 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8;F5H3F0;Q96FW1-2 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 4813690.0 942090.0 1787900.0 2083700.0 False True 1235089.113212539 1521152.2891796168 1868098.7122617734 1.0 1.2316133895982702 1.5125213980736494 20.236183707127406 -6.9685478792382325 0.29078692069759016 0.9456265152754924 1.8071966993895563 0.9999687352631914 0.0011717286583248247 0.07677675707955275 0.010708090611879075 0.004886952833288823 0.025450884500269687 1.0751080674732116e-07 6.9685478792382325 0.8615701841140639 LLTSYGFIQCSER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLTSYGFIQCSER 13 0 O75534-2;O75534;O75534-3;O75534-4;E9PLD4;E9PKN4 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 14621100.0 3634200.0 6702700.0 4284200.0 False True 4764471.393642868 5702683.286919973 3840912.0809482634 1.0 1.196918360036528 0.8061570242762104 22.183884728879384 -6.769755608435105 1.5759554348300908 1.1129856629022448 0.804009037184231 0.7294140419116093 0.08298375269048294 0.2668289470434825 1.30792754988517 0.04151065032851796 0.09881196067984359 1.6991995780841534e-07 6.769755608435105 -0.30897662571801376 LLTSYGFIQCSER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLTSYGFIQCSER 13 0 O75534-2;O75534;O75534-3;O75534-4;E9PLD4;E9PKN4 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 16408400.0 3634200.0 5161800.0 7612400.0 False True 4977861.95056221 4933734.608210028 5814507.902299237 1.0 0.9911352820165699 1.1680733535895937 22.247094790402276 -6.895109574063832 0.9916830393146454 0.9916243510464812 1.1849058107564119 0.9839716885716849 0.010305538439907566 0.11509458301274338 0.19842206450203803 0.007860237705733271 0.01999236053829037 1.2731818121274767e-07 6.895109574063832 0.19328145970993071 LLVATSVAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLVATSVAAR 10 0 A0A0C4DG89;Q7L014 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 8289300.0 2457600.0 4127800.0 1703900.0 False True 3221937.3994322554 3511948.330038378 1527596.7729629206 1.0 1.0900113486553855 0.47412366647226034 21.619497032826754 -6.8697668783267964 1.1352665937216715 1.0508409364495335 0.43820415278493696 0.9644531541547942 0.05120968058810541 0.13708181323797605 0.33034326153199295 0.03501104724393805 0.08286054836696198 1.3496871766228972e-07 6.8697668783267964 -0.6126367836645965 down LLVATSVAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLVATSVAAR 10 0 A0A0C4DG89;Q7L014 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 4875660.0 1764000.0 851560.0 2260100.0 False True 1708002.785564783 1191592.3488267339 1668112.0084533582 1.0 0.6976524622193234 0.976644782169817 20.703878897161513 -10.43870341322216 8.199523079583917 1.0000040684325355 0.8371486224352802 0.3123811835385354 0.11389813767233611 8.471188687968473e-06 5.798343027770361e-07 0.11028415120571479 0.03676046586408311 3.641636445145003e-11 10.43870341322216 -0.16285544599725532 LLVATSVAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLVATSVAAR 10 0 A0A0C4DG89;Q7L014 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 18097000.0 4783200.0 7744100.0 5569700.0 False True 7256464.098760293 6362104.850070539 4468846.353713767 1.0 0.8767499933138858 0.6158435145399854 22.790835298008737 -6.958918768707804 0.45041250010779954 1.0083783047260302 0.4738649329930025 0.9997279729384901 0.0026414252064034614 0.08008962586498074 0.022575587613071026 0.0034894277197126023 0.021579953432064952 1.0992114188669138e-07 6.958918768707804 -0.5345133717330277 LLVATSVAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLVATSVAAR 10 0 A0A0C4DG89;Q7L014 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 7023300.0 2457600.0 2188500.0 2377200.0 False True 3366241.134142776 2091804.833598291 1815754.3199708057 1.0 0.6214067115934568 0.5394011443666804 21.682707094349645 -13.999999999999996 0.21497408495992734 3.2355504736744782 0.49336641938373066 0.9994933798534785 0.004515431884001611 12.867791063832074 0.1469219753182132 12.180207116148189 0.0469371479351736 1.0000000000000082e-14 13.999999999999996 -2.7421840542907474 LLVATSVAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLVATSVAAR 10 0 A0A0C4DG89;Q7L014 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 16785000.0 4783200.0 7280100.0 4721700.0 False True 6191946.69096792 6874956.03527777 3862399.0487332675 1.0 1.1103060763275212 0.6237778265060451 22.561961620101187 -6.847123069737803 1.2489032612202902 1.0587484429258245 0.6053822621453379 0.9360133925783313 0.052685302277052634 0.1606490396603261 0.483641056081778 0.033033182871168215 0.07631299851831483 1.421925786766038e-07 6.847123069737803 -0.4533661807804866 LLVATTFTHSYPFCWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLVATTFTHSYPFCWR 16 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 123251000.0 41467000.0 44533000.0 37251000.0 False True 62908470.64377254 36585738.212082915 29888323.522306696 1.0 0.5815709369133205 0.47510809301903467 25.90675095370046 -13.999999999999902 0.19218877500354906 3.2602533613970874 0.40039008721470315 0.9994883527278987 0.005124497544758915 12.38714681625589 0.13902423180945825 10.492841375210835 0.07196134156304682 1.000000000000225e-14 13.999999999999902 -2.859863274182384 LLVATTFTHSYPFCWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLVATTFTHSYPFCWR 16 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 117026000.0 41467000.0 41526000.0 34033000.0 False True 53679848.93677173 39215041.59571232 27839343.208068974 1.0 0.7305356176002437 0.5186181362183099 25.67787727579291 -7.089519559232242 0.14621297505167075 1.2680425905165649 2.223385811782162e-09 0.9999984882924352 0.00024213442257470542 0.07549733496583028 0.004917234200690236 0.012895703298389447 0.02854966941913501 8.137302121514806e-08 7.089519559232242 -1.268042588293179 LLVFGGMVEYGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLVFGGMVEYGK 12 0 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 13247200.0 2666300.0 6422000.0 4158900.0 False True 4044972.032640186 5275943.924684977 3336891.5920893727 1.0 1.304321484082382 0.8249480009164257 21.947698297069465 -6.735171535954659 1.7043719468472303 1.1820748317159495 0.8249521818275635 0.5830858066591766 0.1278858432827648 0.3266188301217949 1.86097771271109 0.059406698518988235 0.14655863399143068 1.8400450840306894e-07 6.735171535954659 -0.35712264988838605 LLVFTAAGVKPQGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLVFTAAGVKPQGK 14 1 M0R3C8;M0QYH2;Q96T60-2;Q96T60;A0A0D9SFD6;A0A0D9SFL2;A0A0D9SEV0;M0R000;M0QYI1 M0R3C8 PNKP Bifunctional polynucleotide phosphatase/kinase;Polynucleotide 3-phosphatase;Polynucleotide 5-hydroxyl-kinase 0 9086700.0 3465700.0 2360000.0 3261000.0 False True 4543566.261886542 2007897.1992079474 2923583.0017208094 1.0 0.4419209676881096 0.6434555662245154 22.115393688125362 -10.087801265578806 5.120071544636847 1.0000097653892912 0.5426882669552189 0.8728604621579633 0.08227615532562325 9.171724963867637e-06 1.633903958088891e-06 0.07966524485685803 0.026554514946628357 8.169561273420324e-11 10.087801265578806 -0.4573214984340723 LLVFTAAGVKPQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLVFTAAGVKPQGK 14 1 M0R3C8;M0QYH2;Q96T60-2;Q96T60;A0A0D9SFD6;A0A0D9SFL2;A0A0D9SEV0;M0R000;M0QYI1 M0R3C8 PNKP Bifunctional polynucleotide phosphatase/kinase;Polynucleotide 3-phosphatase;Polynucleotide 5-hydroxyl-kinase 0 7216300.0 2627500.0 1539800.0 3049000.0 False True 2544091.4507207857 2154650.169950919 2250375.431960658 1.0 0.8469232382902231 0.8845497402709669 21.278719100453532 -10.714636744389125 6.7720727594299674 1.0015684015724815 0.865736489280595 0.9443740958452393 0.01536095510977381 0.00036777808712898813 1.54974956119084e-05 0.015038023072846253 0.004957726943499476 1.929137821429819e-11 10.714636744389125 -0.13583191229188651 LLVFTAAGVKPQGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLVFTAAGVKPQGK 14 1 M0R3C8;M0QYH2;Q96T60-2;Q96T60;A0A0D9SFD6;A0A0D9SFL2;A0A0D9SEV0;M0R000;M0QYI1 M0R3C8 PNKP Bifunctional polynucleotide phosphatase/kinase;Polynucleotide 3-phosphatase;Polynucleotide 5-hydroxyl-kinase 0 9867000.0 1892100.0 4306100.0 3668800.0 False True 2870454.031038704 3537642.811287135 2943660.0719078328 1.0 1.2324331875842658 1.025503296718059 21.45284752104082 -10.549217032742666 2.8742766564818476 0.9934746776481848 1.128968242251352 0.34120120440373625 0.08447877681338624 28984674.573553205 31837679.668444034 1467523.8611984928 0.03518368693491543 2.82346863236435e-11 10.549217032742666 0.1354935646031673 LLVFTAAGVKPQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLVFTAAGVKPQGK 14 1 M0R3C8;M0QYH2;Q96T60-2;Q96T60;A0A0D9SFD6;A0A0D9SFL2;A0A0D9SEV0;M0R000;M0QYI1 M0R3C8 PNKP Bifunctional polynucleotide phosphatase/kinase;Polynucleotide 3-phosphatase;Polynucleotide 5-hydroxyl-kinase 0 8066300.0 3465700.0 2186600.0 2414000.0 False True 4747062.947020922 2089988.781880749 1843862.917890597 1.0 0.4402698690128698 0.3884218386123858 22.178603749648254 -13.999999999999998 0.3366079655679792 7.341558533372338 0.37993501302940297 0.9997283879690141 0.004563329350743459 19.397090230752696 0.18590220785725703 87.3782237718922 0.016215888453316875 1.0000000000000041e-14 13.999999999999998 -6.961623520342935 LLVFTAAGVKPQGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLVFTAAGVKPQGK 14 1 M0R3C8;M0QYH2;Q96T60-2;Q96T60;A0A0D9SFD6;A0A0D9SFL2;A0A0D9SEV0;M0R000;M0QYI1 M0R3C8 PNKP Bifunctional polynucleotide phosphatase/kinase;Polynucleotide 3-phosphatase;Polynucleotide 5-hydroxyl-kinase 0 4568600.0 2627500.0 926300.0 1014800.0 False True 2184882.667986225 921309.8380438463 1226989.9880949422 1.0 0.4216747432451393 0.5615816382606217 21.05912437588781 -10.15516269499224 7.93965336099156 1.000000099647434 0.49162819075314973 0.9462495304809172 0.057116750714177836 1.0070575930985128e-07 1.0690674252498953e-08 0.05530306678922526 0.018434352025457616 6.995798709504832e-11 10.15516269499224 -0.5083719088942844 LLVFTAAGVKPQGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLVFTAAGVKPQGK 14 1 M0R3C8;M0QYH2;Q96T60-2;Q96T60;A0A0D9SFD6;A0A0D9SFL2;A0A0D9SEV0;M0R000;M0QYI1 M0R3C8 PNKP Bifunctional polynucleotide phosphatase/kinase;Polynucleotide 3-phosphatase;Polynucleotide 5-hydroxyl-kinase 0 7727700.0 1892100.0 3334400.0 2501200.0 False True 2449360.7488669474 3148837.7088268353 2046007.2644792416 1.0 1.285575311959849 0.8353229573984585 21.22397384313327 -6.735297976634697 1.7037093118453124 1.1708313357156084 0.8353094391807586 0.5837625375391526 0.12000736870402658 0.3263799333142055 1.8581860274110142 0.05576507739452702 0.13756583979662637 1.8395094504989693e-07 6.735297976634697 -0.33552189653484976 LLVGVDEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLVGVDEK 8 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 10744400.0 2036800.0 3336000.0 5371600.0 False True 2670264.5243992577 2838281.8036261536 4815798.360025601 1.0 1.062921586116902 1.8034911208315718 21.348551236006955 -6.923674499894207 0.7969941130377435 0.9857211022973026 1.9336298887612797 0.9951424016201993 0.02542833989125172 0.09605757268324999 0.09476031522675256 0.022346880896281753 0.0694842580439256 1.192135168681233e-07 6.923674499894207 0.9479087864639771 LLVGVDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLVGVDEK 8 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 11863800.0 2036800.0 4134600.0 5692400.0 False True 2789860.0024503595 3951919.700706192 4347972.3586580055 1.0 1.4165297531901904 1.5584912342695123 21.411761297529846 -11.9151961526154 0.18195949397001987 1.6685783918843105e-23 1.6825234375528557 0.9994574644607004 0.005520520851212652 5.093697511094987 0.11621382276368276 2.0407175078824884 0.10306824932840258 1.215636824431732e-12 11.9151961526154 1.6825234375528557 LLVGVDEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLVGVDEK 8 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 4908290.0 2902500.0 1409000.0 596790.0 False True 2413557.352551863 1401409.4373353985 721576.0297548083 1.0 0.5806406198939847 0.29896784055779047 21.202729678791197 -8.255249036569136 0.2175453058274353 1.252231589379235 3.501672769371257e-16 0.9996887970837723 0.0050811056780011585 0.09029098563057948 0.047528035685835975 0.10648545302108348 0.11210414525111473 5.555855776427939e-09 8.255249036569136 -1.2522315893792346 down LLVHLK(ub)ATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLVHLKATR 9 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 6723100.0 1936800.0 3750200.0 1036100.0 True False 2539163.5559978825 3190684.778165102 928894.3109729922 1.0 1.2565889151284602 0.36582689160720094 21.275921896104535 -6.829667119654453 1.329370628231059 1.1371357265213438 0.3420147884372916 0.9052152887027256 0.11526207143883715 0.18121970546640556 0.626451748123518 0.06807883680343262 0.1566728111265234 1.4802425376354416e-07 6.829667119654453 -0.7951209380840522 down LLVHLK(ub)ATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLVHLKATR 9 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 7921100.0 2454300.0 2815400.0 2651400.0 True False 2376389.5899158996 3939603.9021170437 1956918.799704984 1.0 1.6578106211349235 0.8234839977456051 21.180339943074205 -6.696510304822724 1.8433384343128587 1.4098658438645384 0.8261249241920541 0.40100852346436877 0.2778517421125078 0.40283453707359573 2.6586173686119015 0.12036535847240415 0.31088559566548646 2.0113594726378051e-07 6.696510304822724 -0.5837409196724843 LLVHLK(ub)ATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLVHLKATR 9 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 5682300.0 1936800.0 2479000.0 1266500.0 True False 2652887.3000519746 2369469.583043253 967378.7843862623 1.0 0.8931663184473879 0.36465129309010214 21.339131957627426 -6.940043794385026 0.6591647472720852 1.005928057100529 0.22194801997536956 0.9981695113427189 0.01188420286526037 0.08774690724569227 0.05452060587088594 0.011572135170550316 0.045479543636008035 1.1480378471808614e-07 6.940043794385026 -0.7839800371251593 down LLVHMGLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLVHMGLLK 9 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 39882100.0 9159100.0 14379000.0 16344000.0 False True 13895024.319902025 11812955.106360216 13113601.236170325 1.0 0.8501572098323258 0.9437623809976023 23.728065023843307 -10.319961562417484 5.041365330007228 1.0000384311392942 0.8969597954177521 0.617688670658433 0.038214151106886245 1.651279127674007e-05 2.2274742959837164e-06 0.03701448551721254 0.012333564235523193 4.786724557386992e-11 10.319961562417484 -0.10307863572154219 LLVHMGLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLVHMGLLK 9 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 12990400.0 2204000.0 6810100.0 3976300.0 False True 3018878.360860461 6509207.264010845 3037179.834469085 1.0 2.1561674522571845 1.0060623421751276 21.525581197087007 -6.644928250453821 2.026835715429157 1.7531890711270426 1.0108790972701507 0.1739055859742893 0.49407596057476977 0.5208956472753112 4.095663664859627 0.19810951865643264 0.5471050854008275 2.265018479108116e-07 6.644928250453821 -0.7423099738568919 LLVHMGLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLVHMGLLK 9 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 37445100.0 9159100.0 16186000.0 12100000.0 False True 11856635.502852537 15285234.871362483 9897924.156484414 1.0 1.2891713562152665 0.8348004081008575 23.499191345935756 -6.734769436253626 1.705911780436474 1.1730907856659896 0.8348296954679107 0.5812126573921679 0.12152183141929059 0.3273619038358899 1.8684270813254873 0.05640419705286491 0.1392099937172142 1.841749513240313e-07 6.734769436253626 -0.3382610901980788 LLVLDVDYTLFDHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLVLDVDYTLFDHR 14 0 Q8WVY7 Q8WVY7 UBLCP1 Ubiquitin-like domain-containing CTD phosphatase 1 0 19527700.0 2790100.0 12776000.0 3961600.0 False True 4232785.683632522 10496022.98065639 3178588.02356904 1.0 2.479696295808872 0.750944711389502 22.013176012625436 -6.680087757078198 1.9015621622141767 1.9361446325414808 0.7575175914781856 0.3245391930785875 0.627117752604696 0.43832377719919474 3.0644233780444488 0.26461952221490437 0.6978412324164364 2.0888739933225463e-07 6.680087757078198 -1.178627041063295 LLVPAAEGEDSLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLVPAAEGEDSLKK 14 1 Q96PU8-9;Q96PU8-8;Q96PU8-6;Q96PU8;Q96PU8-5;Q96PU8-3;F5GXS8;F5GYM3;H0YG47;H0YGD6 Q96PU8-9 QKI Protein quaking 1 8758500.0 2392500.0 1155300.0 5210700.0 True False 2316551.397088287 1616617.3148099114 3845861.3523507398 1.0 0.6978551465950056 1.6601666413206582 21.14354726097738 -6.822320793510236 1.3618297593356035 0.8375135635843024 1.6822328435192366 0.8896200657832131 0.13349953981151963 0.1904925260346765 0.6935453100063809 0.07702131013015366 0.17741903001681666 1.5054946152255888e-07 6.822320793510236 0.8447192799349342 LLVPAAEGEDSLK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLVPAAEGEDSLKK 14 1 Q96PU8-9;Q96PU8-8;Q96PU8-6;Q96PU8;Q96PU8-5;Q96PU8-3;F5GXS8;F5GYM3;H0YG47;H0YGD6 Q96PU8-9 QKI Protein quaking 1 5651100.0 1136700.0 1492000.0 3022400.0 True False 1556968.7081624737 1426078.5066157882 2308571.3682819153 1.0 0.9159326704123929 1.4827345958715374 20.570308518858354 -6.869177150936328 1.138521748143046 0.952688681057953 1.5154026887107304 0.9638507792824565 0.04748436742226338 0.13764192668625452 0.3339839980541742 0.03238539903968293 0.07656158456450898 1.3515211583612198e-07 6.869177150936328 0.5627140076527773 LLVPTQFVGAIIGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLVPTQFVGAIIGK 14 0 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 0 36352300.0 6984900.0 15520700.0 13846700.0 False True 10596603.964590797 12750909.82121741 11109893.675775805 1.0 1.203301535456582 1.0484390766041836 23.33709864329673 -10.358489276968612 3.601756405894934 0.9993847257452368 1.1258703059684487 0.4683203566493631 0.06322233424925615 7356110.562365888 10578152.001082754 27940.556767841743 0.021642687842798065 4.380369264717761e-11 10.358489276968612 0.12648558022321188 LLVPTQFVGAIIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLVPTQFVGAIIGK 14 0 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 0 34717300.0 6984900.0 17631900.0 10100500.0 False True 9042090.74296324 16650669.265314227 8262312.639881902 1.0 1.8414623054156094 0.913761305294555 23.10822496538918 -6.667859967747282 1.9446797484269047 1.5380713638243393 0.9175188070590365 0.2697547073730103 0.3576090218429781 0.4660278685239599 3.3955994660166366 0.1481418040179466 0.39694592358641634 2.1485231240405382e-07 6.667859967747282 -0.6205525567653027 LLVPTQFVGAIIGK(ub)EGATIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLVPTQFVGAIIGKEGATIR 20 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 24736900.0 7163100.0 7740000.0 9833800.0 True False 6935711.311382698 10830622.363566775 7258032.772323623 1.0 1.5615734100396965 1.0464727331444637 22.725612419108792 -10.390824959047006 3.876901390937728 0.9987031870554594 1.304023071572215 0.3171640478005763 0.2102889713204137 113838531.65419416 2490.3849006169908 1343222.2730514433 0.07695751153095379 4.0660717782042134e-11 10.390824959047006 0.3053198845167556 LLVPTQFVGAIIGK(ub)EGATIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLVPTQFVGAIIGKEGATIR 20 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 19128900.0 7163100.0 6747700.0 5218100.0 True False 5956435.029134962 6711348.8007864235 6309180.584231576 1.0 1.1267391934871984 1.0592209187829993 22.50601769454307 -10.126568385912618 4.956891518085763 0.9999956469661997 1.0929800561354095 0.7165993898641945 0.02756422022415066 1.3263583850999745e-06 2.3365446432596911e-07 0.02669019102468434 0.008896313823121432 7.471909689625932e-11 10.126568385912618 0.0929844091692098 LLVQHEINTLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLVQHEINTLR 11 0 J3KNE0;A6NKT7;Q7Z3J3;P49792 J3KNE0;P49792 RGPD3;RGPD4;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;E3 SUMO-protein ligase RanBP2 0 3643800.0 1679400.0 1964400.0 0.0 False True 2201709.6633327333 1671319.1771712264 0.0 1.0 0.7591006230318972 0.0 21.070192804399667 -7.318212580394018 0.807077416559729 0.9890925203088222 1.0461214485452414e-19 0.9881063795203362 0.04647262327991545 0.10578661877733848 0.13754838061444002 0.03972403848918988 0.07045022016230931 4.806040426614394e-08 7.318212580394018 -0.9890925203088222 down LLVQHEINTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLVQHEINTLR 11 0 J3KNE0;A6NKT7;Q7Z3J3;P49792 J3KNE0;P49792 RGPD3;RGPD4;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;E3 SUMO-protein ligase RanBP2 0 5819400.0 1679400.0 1886200.0 2253800.0 False True 2300319.564078521 1802861.4471707067 1721498.8584680313 1.0 0.7837439090307047 0.7483737848213459 21.13340286592256 -13.999999999999998 0.25479507062628015 2.5410663739020642 0.7347869096911954 0.9995519038896803 0.0023543766826109183 14.193273193892907 0.15972523280625875 11.226971737573965 0.015899264063449832 1.0000000000000041e-14 13.999999999999998 -1.8062794642108688 LLVSASQDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLVSASQDGK 10 0 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;F5H8J8;F5H100;F5H0S8;E9PCP0;P16520-2;P16520;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1;Q9HAV0;C9JD14 P62873;P62879;Q9HAV0 GNB1;GNB3;GNB2;GNB4 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein subunit beta-4 0 9864700.0 2278400.0 3607800.0 3978500.0 False True 2987004.4640569887 3069530.303094256 3566842.9844667967 1.0 1.027628294510541 1.1941204063760467 21.510267963071996 -6.935741905501086 0.6980433852110565 0.9979245312744842 1.2339024166151402 0.9975514396123151 0.004242776334991079 0.08976370638391382 0.06386260416952826 0.004007246489867309 0.01461845607788903 1.1594662042955215e-07 6.935741905501086 0.235977885340656 LLVSASQDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLVSASQDGK 10 0 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;F5H8J8;F5H100;F5H0S8;E9PCP0;P16520-2;P16520;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1;Q9HAV0;C9JD14 P62873;P62879;Q9HAV0 GNB1;GNB3;GNB2;GNB4 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein subunit beta-4 0 7223200.0 2174400.0 1146800.0 3902000.0 False True 2105374.8622063845 1604723.2204829948 2879949.142509178 1.0 0.7622030875780865 1.367903262363006 21.00564569748402 -6.800212727089107 1.4549986539525532 0.8688284386935244 1.3763118334041085 0.8327776841756127 0.1018928060870194 0.2204659187489825 0.9214133197451436 0.055090441695329284 0.1281060785811553 1.5841170666497298e-07 6.800212727089107 0.507483394710584 LLVSASQDGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLVSASQDGK 10 0 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;F5H8J8;F5H100;F5H0S8;E9PCP0;P16520-2;P16520;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1;Q9HAV0;C9JD14 P62873;P62879;Q9HAV0 GNB1;GNB3;GNB2;GNB4 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein subunit beta-4 0 24701000.0 1650500.0 20832000.0 2218500.0 False True 2503929.1677127997 17114366.838841088 1780012.5025969052 1.0 6.835004384119265 0.7108877222045573 21.25576232055842 -6.657115797450925 1.9829851049021443 4.764782273579816 0.7364554149737098 0.2234647725529768 2.4861308389746046 0.4913251727949326 3.7108393310088097 1.0139580489604978 2.755444652949197 2.2023391673947644e-07 6.657115797450925 -4.028326858606106 LLVSASQDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLVSASQDGK 10 0 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;F5H8J8;F5H100;F5H0S8;E9PCP0;P16520-2;P16520;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1;Q9HAV0;C9JD14 P62873;P62879;Q9HAV0 GNB1;GNB3;GNB2;GNB4 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein subunit beta-4 0 9536700.0 2278400.0 3064600.0 4193700.0 False True 3120786.051444867 2929195.8387230174 3203234.43196263 1.0 0.9386083475241287 1.0264191069681277 21.573478024594888 -6.718744749192429 1.7637864301394837 0.9626002221365322 1.026273083816228 0.5066064367174508 0.025837883302879495 0.35776289596045674 2.1744340992798037 0.011634566833447862 0.02925083885338924 1.910976079355656e-07 6.718744749192429 0.06367286167969577 LLVSASQDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLVSASQDGK 10 0 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;F5H8J8;F5H100;F5H0S8;E9PCP0;P16520-2;P16520;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1;Q9HAV0;C9JD14 P62873;P62879;Q9HAV0 GNB1;GNB3;GNB2;GNB4 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein subunit beta-4 0 4031960.0 2174400.0 1356700.0 500860.0 False True 1808109.9422528055 1349391.1878161351 605587.510285014 1.0 0.7462993019854025 0.33492847759605004 20.786050972918297 -6.963931018327742 0.3759518260745571 1.0295753856077126 0.03719835530826518 0.9998893788440213 0.0028823150392229156 0.07832566080545088 0.016150920197715888 0.005378070166520413 0.03482956450177458 1.0865982010077657e-07 6.963931018327742 -0.9923770302994473 down LLVSASQDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLVSASQDGK 10 0 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5;F5H8J8;F5H100;F5H0S8;E9PCP0;P16520-2;P16520;P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1;Q9HAV0;C9JD14 P62873;P62879;Q9HAV0 GNB1;GNB3;GNB2;GNB4 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3;Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;Guanine nucleotide-binding protein subunit beta-4 0 7638200.0 1650500.0 3459900.0 2527800.0 False True 2136604.786218965 3267353.5235034684 2067766.3374182906 1.0 1.5292269045626958 0.9677813841639407 21.02688864265087 -6.659483274809231 1.9744963844015118 1.340795134324281 0.9701123363878996 0.23352257833783452 0.225359298403881 0.4856567959671321 3.6391688676451373 0.09222435261442624 0.2498437570955212 2.190366180019343e-07 6.659483274809231 -0.37068279793638137 LLVSMCQGNR ddPTM_RPMI8226_Bortezomib_1h_R1 2 LLVSMCQGNR 10 0 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 0 45786540.0 13560160.0 11503680.0 20722700.0 False True 17777501.076776244 9787375.784993429 18578513.79017473 1.0 0.5505484568795348 1.0450576664256201 24.08354920786657 -6.667479398264227 1.9466982404953699 0.7124961583191789 1.0430233147387995 0.2678427962797344 0.1910288885551251 0.46688030325265323 3.4087062791762968 0.07907598549218436 0.21193800201654295 2.150406686299665e-07 6.667479398264227 0.3305271564196206 LLVSMCQGNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLVSMCQGNR 10 0 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 0 14423200.0 7233000.0 1917700.0 5272500.0 False True 7003392.374144023 2683447.61067339 3891474.078390476 1.0 0.38316396787654916 0.5556555838221336 22.739622487927672 -10.794843220604868 10.72345767661466 1.003347874759756 0.46940977584965315 0.9265569228203022 0.07041940732913408 0.00563342460409524 0.00010777604095152191 0.06814780916527255 0.022727765986294394 1.6038242633858774e-11 10.794843220604868 -0.5339380989101028 LLVSMCQGNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLVSMCQGNR 10 0 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 0 25664200.0 7599800.0 10413000.0 7651400.0 False True 11529452.219802322 8554718.792859653 6139097.436272242 1.0 0.7419883121738049 0.5324708684535838 23.458820634395668 -6.9734958077549205 0.15316319010195376 1.2330417592630345 0.035891874358517074 0.9999984035502568 0.00024152605362870973 0.07518387102533215 0.004695923917453533 0.010362686301952098 0.025807139837279707 1.0629288436793859e-07 6.9734958077549205 -1.1971498849045175 LLVSMCQGNR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LLVSMCQGNR 10 0 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 0 40975550.0 13560160.0 10285590.0 17129800.0 False True 18573717.60154521 9831138.623902338 13084094.039305028 1.0 0.5293037632425537 0.7044413143342136 24.146759269389463 -10.080585845984377 5.01456753451644 1.0000093946134267 0.6168725387867211 0.8645110716122814 0.07149960583496584 7.509751721652849e-06 1.3769495334682973e-06 0.06923089182274784 0.023076398554109118 8.306425112918276e-11 10.080585845984377 -0.38313685582670565 LLVSMCQGNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLVSMCQGNR 10 0 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 0 14968300.0 7233000.0 2233700.0 5501600.0 False True 6014559.9762300085 2221666.6147452667 6651959.123475684 1.0 0.3693814050446682 1.1059760231446232 22.52002776336195 -6.680053370686581 1.901853875509016 0.6010183995262827 1.1031638159672463 0.3243284825615691 0.26726797428585897 0.43838755462376566 3.0658266828243077 0.112765287678743 0.2973735351327949 2.0890393918847157e-07 6.680053370686581 0.5021454164409637 LLVVDPETDEQLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLVVDPETDEQLQK 14 0 O14745;J3QRP6 O14745 SLC9A3R1 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 0 8778690.0 2985600.0 936790.0 4856300.0 False True 2890823.7622348135 1310855.1322953135 3584289.344122839 1.0 0.45345383880542367 1.2398851119695817 21.463049227568387 -6.719785490656019 1.7599177067260279 0.6674159868285184 1.2386587203798982 0.5115810982021869 0.22999454012952658 0.3557347575828531 2.1531699487085305 0.10376644161698795 0.2605750025293568 1.9064021070568113e-07 6.719785490656019 0.5712427335513798 LLVVTDPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLVVTDPR 8 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 14333600.0 1987800.0 7112600.0 5233200.0 False True 2606025.0498825833 6051427.804697658 4691718.664399054 1.0 2.3220911882525113 1.8003352134356665 21.313419520907768 -9.909020653330115 5.635942579915007 0.9999992464724848 2.0612132008462254 0.8465270986093293 0.21300598476582708 2.016575080750029e-06 3.9043130080114085e-07 0.20624230232913748 0.06874738596894936 1.2330461930281096e-10 9.909020653330115 1.0612139543737404 LLVVTDPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLVVTDPR 8 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 8957100.0 3764200.0 1798700.0 3394200.0 False True 3644707.5314189065 2516930.2900965856 2505157.1961826384 1.0 0.6905712648819121 0.6873410759538683 21.79737161984334 LLVVTDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLVVTDPR 8 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 17955100.0 1987800.0 10654000.0 5313300.0 False True 2722743.3782751504 10183271.051933385 4058407.970848428 1.0 3.74007742822405 1.4905583843231738 21.37662958243066 -6.597432588057297 2.20100628404602 2.8458389804643773 1.497741707893965 0.013136802224194666 1.1851272021835766 0.6479498839980203 5.928727709925986 0.4476623214395446 1.318511180007217 2.5267798908506235e-07 6.597432588057297 -1.3480972725704123 LLVYSHLDLWMVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLVYSHLDLWMVK 13 0 Q92813-2 Q92813-2 0 866387000.0 160283000.0 310324000.0 395780000.0 False True 210132565.1827801 264024868.83347777 354828482.1898376 1.0 1.2564681186079865 1.6885934927848822 27.646724519334693 -6.963253850204904 0.38685568930847397 0.9725127658116979 1.9879975437725972 0.9998724966372813 0.003208538449761024 0.07855864262262363 0.016981258137271436 0.005590364752157879 0.03639912365039465 1.0882937869383228e-07 6.963253850204904 1.0154847779608993 LLVYSHLDLWMVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLVYSHLDLWMVK 13 0 Q92813-2 Q92813-2 0 380696000.0 63957000.0 103499000.0 213240000.0 False True 61926720.04329186 144826690.44015476 157386046.93712404 1.0 2.338678527441935 2.541488501685513 25.88405869976173 -10.501374658703313 0.3876219662155153 2.6933414335032858e-20 2.56397160876218 0.9992477368868194 0.018757399031380528 1.977008339661806 0.18372201036992944 2.0104148424748756 0.053495858034102686 3.1522840264768025e-11 10.501374658703313 2.56397160876218 LLVYSHLDLWMVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLVYSHLDLWMVK 13 0 Q92813-2 Q92813-2 0 1340178000.0 206480000.0 829320000.0 304378000.0 False True 313245255.70999 681321366.493265 244217554.88638353 1.0 2.1750412945569035 0.7796368833515104 28.222717418317217 -6.6834716165785935 1.8898644180434148 1.741161341647685 0.7848436223667954 0.3398878616394587 0.4976417725016461 0.4308904551247968 2.9784254067344627 0.21107719787265602 0.5541748312519574 2.0726615144531562e-07 6.6834716165785935 -0.9563177192808896 LLVYSHLDLWMVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLVYSHLDLWMVK 13 0 Q92813-2 Q92813-2 0 440729000.0 160283000.0 128016000.0 152430000.0 False True 219543956.58520782 122359829.82769886 116429173.39439249 1.0 0.5573363609314813 0.5303228346857493 27.709934580857585 -13.999999999999998 0.3978309449654032 8.358668882983999 0.5286556800156609 0.999834678483661 0.002768566490734806 26.454284440696494 0.20763628050286004 167.90294810705367 0.0069541583667247445 1.0000000000000041e-14 13.999999999999998 -7.830013202968337 LLVYSHLDLWMVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLVYSHLDLWMVK 13 0 Q92813-2 Q92813-2 0 541531000.0 63957000.0 114040000.0 363534000.0 False True 53183079.27550716 113425643.88483222 439547278.60869706 1.0 2.1327393116379603 8.264795581536125 25.664463975196007 -6.938049520494946 0.6774661719972507 0.9282946706102349 9.827658962669828 0.997897101716475 0.14634694121306144 0.08866785717828021 0.058746982561434014 0.14043441859281877 0.5324686483701759 1.1533217426345215e-07 6.938049520494946 8.899364292059593 LLVYSHLDLWMVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLVYSHLDLWMVK 13 0 Q92813-2 Q92813-2 0 903228000.0 206480000.0 322290000.0 374458000.0 False True 267292430.32928905 304354278.18432075 306310486.26354086 1.0 1.1386565560774526 1.145975162432336 27.993843740409666 -12.86333054879928 0.4331427166078087 0.06300178156775725 1.1461111429126358 0.9998563018318362 0.0008049923527813925 11.79197864564489 0.2200756602556046 10.147952953487467 0.001718954551373774 1.3698387620814636e-13 12.86333054879928 1.0831093613448786 LLYDLADQLHAAVGASR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLYDLADQLHAAVGASR 17 0 P13804;P13804-2;H0YL12;H0YNX6;H0YK49 P13804 ETFA Electron transfer flavoprotein subunit alpha, mitochondrial 0 24313600.0 7972600.0 16341000.0 0.0 False True 12095017.075133007 13424820.87718426 0.0 1.0 1.109946417916622 0.0 23.52790947025466 -6.955092402886893 1.1950058648278015 1.0632615378863275 1.4388888594403326e-19 0.9734868380685988 0.08130694348396307 0.10558455560010045 0.29927455750103404 0.05666279934269812 0.10723622042293456 1.1089388462211794e-07 6.955092402886893 -1.0632615378863275 down LLYDLADQLHAAVGASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLYDLADQLHAAVGASR 17 0 P13804;P13804-2;H0YL12;H0YNX6;H0YK49 P13804 ETFA Electron transfer flavoprotein subunit alpha, mitochondrial 0 16420300.0 2149700.0 2660600.0 11610000.0 False True 2944502.1834581364 2543045.8945723586 8867957.115455605 1.0 0.8636590282930977 3.0116999624842307 21.489592312661966 -6.891764142889079 1.0118741561920737 0.8894165990445843 3.202975619430173 0.982004032650926 0.13173959839562668 0.11772417590158958 0.21357368402223517 0.09896292203657477 0.24833925908699725 1.2830271812556093e-07 6.891764142889079 2.3135590203855885 up LLYDLADQLHAAVGASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLYDLADQLHAAVGASR 17 0 P13804;P13804-2;H0YL12;H0YNX6;H0YK49 P13804 ETFA Electron transfer flavoprotein subunit alpha, mitochondrial 0 31793200.0 7972600.0 15463000.0 8357600.0 False True 10320687.86344095 14602470.45693057 6836602.556217697 1.0 1.4148737613368787 0.6624173356152981 23.29903579234711 -6.757031280846529 1.623671411483191 1.2418725665866128 0.6600683531312871 0.678700498454328 0.17443078183759128 0.2879447087975645 1.4954312763624324 0.0847918402368241 0.2043678180813725 1.7497206572869605e-07 6.757031280846529 -0.5818042134553257 LLYEEAK(ub)GNVLAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLYEEAKGNVLAAR 14 1 Q9BZ67-2;Q9BZ67-3;Q9BZ67;E9PS62;E9PRP1;Q9BZ68 Q9BZ67-2 FRMD8;FRMD8P1 FERM domain-containing protein 8;Putative FERM domain-containing protein FRMD8P1 1 8585820.0 922720.0 0.0 7663100.0 True False 893428.7586713915 0.0 5655904.221927759 1.0 0.0 6.330559842665681 19.768993168886386 -6.866501723511977 1.1525294943790187 0.444861418349733 6.6773346286554265 0.9610604858948517 0.5483247388635074 0.14024840757547788 0.3503955139095965 0.36997505249784596 0.870937398175089 1.3598727665738805e-07 6.866501723511977 6.2324732103056935 up LLYEEAK(ub)GNVLAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLYEEAKGNVLAAR 14 1 Q9BZ67-2;Q9BZ67-3;Q9BZ67;E9PS62;E9PRP1;Q9BZ68 Q9BZ67-2 FRMD8;FRMD8P1 FERM domain-containing protein 8;Putative FERM domain-containing protein FRMD8P1 1 57766200.0 3630200.0 11737000.0 42399000.0 True False 5507278.803169337 9642440.648400437 34018819.065858155 1.0 1.7508539140693933 6.177064986483153 22.39290821535942 -6.936209823365089 0.6939257367538323 0.945592115409689 7.248387631574557 0.9976241579938718 0.11133668494402946 0.08953901581069006 0.06280682939328726 0.10548626841940678 0.3877406036211874 1.1582176441409773e-07 6.936209823365089 6.302795516164868 LLYEEAK(ub)GNVLAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLYEEAKGNVLAAR 14 1 Q9BZ67-2;Q9BZ67-3;Q9BZ67;E9PS62;E9PRP1;Q9BZ68 Q9BZ67-2 FRMD8;FRMD8P1 FERM domain-containing protein 8;Putative FERM domain-containing protein FRMD8P1 1 3536720.0 922720.0 2614000.0 0.0 True False 767282.5634269259 2599917.8631616267 0.0 1.0 3.388475103030588 0.0 19.549398444320662 -6.717321191372484 1.7692537825451633 2.4572699969069784 0.006160581409510023 0.49974941492332325 1.0054211779387667 0.36052844392058275 2.2041285824288814 0.451506889905974 1.1369097690115157 1.9172502745276018e-07 6.717321191372484 -2.4511094154974686 LLYEEAK(ub)GNVLAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LLYEEAKGNVLAAR 14 1 Q9BZ67-2;Q9BZ67-3;Q9BZ67;E9PS62;E9PRP1;Q9BZ68 Q9BZ67-2 FRMD8;FRMD8P1 FERM domain-containing protein 8;Putative FERM domain-containing protein FRMD8P1 1 42379200.0 3630200.0 6934000.0 31815000.0 True False 4699365.461940063 6548116.804524134 26024996.44946709 1.0 1.3934044622741133 5.537980959395964 22.16403453745187 -6.9253587965942085 0.7839459082496892 0.9249688751220412 6.296322757713384 0.9955448425506623 0.13701756087136086 0.09512057856134674 0.09001670864503722 0.12153971881097182 0.38502583911614136 1.1875207402945179e-07 6.9253587965942085 5.371353882591342 up LLYMHMLGYPAHFGQLECLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LLYMHMLGYPAHFGQLECLK 20 0 O43747;O43747-2;H3BR36;H3BUN9;H3BNR4;H3BS13;H3BV30;H3BRM7;H3BN71;B4DGE1 O43747 AP1G1 AP-1 complex subunit gamma-1 0 39736000.0 10048000.0 14936000.0 14752000.0 False True 15243550.607196707 12270554.104499346 11836260.733968712 1.0 0.8049669280270066 0.7764766253592281 23.86169564622751 -13.999999999999945 0.270906230170995 2.5126876051723843 0.7671024095204085 0.9995852767723155 0.0020229851974136754 14.92789592755692 0.1647759003391559 12.443223835938907 0.011779487050259123 1.0000000000001268e-14 13.999999999999945 -1.7455851956519757 LLYNNVSNFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLYNNVSNFGR 11 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 8819400.0 2552400.0 3655200.0 2611800.0 False True 3346221.1174767576 3109858.4078580076 2341555.9901546757 1.0 0.9293642884553365 0.6997612853272359 21.674101350787424 -6.949635600878978 0.5628368355788687 1.002959502359038 0.6151395438807766 0.9991723244907769 0.0036873916327032634 0.08363254427298075 0.036571516184626625 0.003939266100118226 0.019098191272927025 1.1229602901613725e-07 6.949635600878978 -0.38781995847826145 LLYNNVSNFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLYNNVSNFGR 11 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 7015300.0 2552400.0 1827200.0 2635700.0 False True 3496091.2560164435 1746468.2622576198 2013201.9439454216 1.0 0.49954882020087793 0.5758436483832883 21.737311412310316 -10.692234724454293 6.76484274978013 1.003827751512793 0.5376962342921423 0.9799822697201275 0.031147233176703183 0.0018065961899248954 8.219064465359388e-05 0.030300055810744037 0.010052726281150878 2.031258873569212e-11 10.692234724454293 -0.4661315172206506 LLYNRPGTVSSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLYNRPGTVSSLK 13 1 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2 H0Y993 DEK Protein DEK 0 10527700.0 1533200.0 5636500.0 3358000.0 False True 2010040.047529921 4795556.170904922 3010546.3722105087 1.0 2.3858013061968792 1.4977544233061826 20.938792814906115 -10.057969083281805 4.900547196287447 0.9999798222375432 1.941777864759354 0.5999296196845387 0.36254362182659455 9.021859751149866e-05 1.7343723063283262e-05 0.3510398181078503 0.11701045079570246 8.750460661172243e-11 10.057969083281805 0.9417980425218108 LLYNRPGTVSSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLYNRPGTVSSLK 13 1 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2 H0Y993 DEK Protein DEK 0 7016500.0 3163000.0 1252300.0 2601200.0 False True 3062592.2963386625 1752349.9206582254 1919867.685672702 1.0 0.5721786483800552 0.6268766782858787 21.546321892121384 -10.119192433058554 5.1571630772212655 1.0000114842928753 0.5995276633328712 0.9862017068504558 0.022330377202718958 2.9486438379508607e-06 5.036845538078691e-07 0.021621914231059393 0.007207098251444936 7.599894559421597e-11 10.119192433058554 -0.4004838209600041 LLYNRPGTVSSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLYNRPGTVSSLK 13 1 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2 H0Y993 DEK Protein DEK 0 10304200.0 1533200.0 4100100.0 4670900.0 False True 2100065.4731720802 3918944.024782429 3567729.620205134 1.0 1.8661056404412917 1.6988659000312953 21.002002876429007 -10.08541727942389 4.539958619591241 0.9999522401727294 1.782485770154099 0.9668748682664328 0.0682753383610425 23728458.345064867 1.4555781334603168 13672.34697279335 0.023372464301165696 8.21453001045104e-11 10.08541727942389 0.7825335299813696 LLYPPETGLFLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLYPPETGLFLVR 13 0 P41240;H3BUM9;H3BU69 P41240 CSK Tyrosine-protein kinase CSK 0 10843700.0 1995800.0 4621600.0 4226300.0 False True 2616513.127354693 3932075.294855699 3789003.017532245 1.0 1.50279211433999 1.4481116023915936 21.31921406646599 -10.457807224359529 6.00107012907814 0.9997349244452913 1.4754518583657918 0.9901774024903163 0.022323225524622032 7.921242774937065e-05 7.156760188599093e-06 0.021626128259513953 0.007204790057541065 3.484919701319652e-11 10.457807224359529 0.4757169339205005 LLYPPETGLFLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLYPPETGLFLVR 13 0 P41240;H3BUM9;H3BU69 P41240 CSK Tyrosine-protein kinase CSK 0 6549200.0 2337600.0 1402500.0 2809100.0 False True 2263394.1675375476 1962525.5639408822 2073312.4388063932 1.0 0.8670719365138267 0.9160191664989783 21.110056419520127 -10.44621759524032 7.98252204606898 1.0000041178177026 0.8915455518942366 0.8674797772934285 0.01998262296437966 1.4644510046102612e-06 1.0160634426504652e-07 0.019348826015102523 0.006449363829548687 3.5791706442675537e-11 10.44621759524032 -0.10845856592346603 LLYPPETGLFLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLYPPETGLFLVR 13 0 P41240;H3BUM9;H3BU69 P41240 CSK Tyrosine-protein kinase CSK 0 12232600.0 1995800.0 5135000.0 5101800.0 False True 2733701.194467021 4908118.720825785 3896859.914869194 1.0 1.7954115580590004 1.4254886096389732 21.38242412798888 -10.113025051382467 4.507998957837985 0.9999448877026682 1.6104500836868134 0.7840601175655153 0.1510204114118311 105258825.41276664 8.10443395273494 66930.16921392972 0.05169830371599797 7.70859002368509e-11 10.113025051382467 0.6105051959841452 LLYPPETGLFLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLYPPETGLFLVR 13 0 P41240;H3BUM9;H3BU69 P41240 CSK Tyrosine-protein kinase CSK 0 4950800.0 2337600.0 1234500.0 1378700.0 False True 1943817.9732386672 1227849.5034709356 1666979.7956114437 1.0 0.6316689733170694 0.8575801945251215 20.890461694954404 -10.374735400202882 5.759767590236325 1.0000639440750958 0.7446245839210949 0.6301516020510416 0.09222786985479303 7.574910661053925e-05 8.223131332593434e-06 0.08932154561420072 0.029766417000316226 4.21953506019837e-11 10.374735400202882 -0.2554393601540009 LLYSGVPFLGPYHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLYSGVPFLGPYHK 14 0 Q9Y5Y6 Q9Y5Y6 ST14 Suppressor of tumorigenicity 14 protein 0 16136100.0 4908100.0 4388300.0 6839700.0 False True 6434566.630108014 3733582.745459429 6131993.455035202 1.0 0.580238415434165 0.9529769147688921 22.617411555120896 -10.270304511633931 8.044764233481132 1.0000003146722334 0.7666076651015286 0.34329824627689554 0.1521698551434681 8.588317913392117e-07 7.791630313573376e-08 0.1473380273797137 0.04911260956378728 5.366553810150671e-11 10.270304511633931 -0.23339264957070482 LLYSGVPFLGPYHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LLYSGVPFLGPYHK 14 0 Q9Y5Y6 Q9Y5Y6 ST14 Suppressor of tumorigenicity 14 protein 0 12867100.0 4240500.0 1914100.0 6712500.0 False True 4105887.6486323453 2678410.1118996358 4954294.879316473 1.0 0.6523339996387392 1.2066318670377474 21.969262720156323 -6.737149917339173 1.6972478134566924 0.792459589089962 1.2067519248341207 0.5920402750000955 0.1460872473783594 0.3229921432605852 1.8257869785034002 0.06812543809518601 0.16769202759385304 1.8316820212988872e-07 6.737149917339173 0.4142923357441588 LLYSGVPFLGPYHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLYSGVPFLGPYHK 14 0 Q9Y5Y6 Q9Y5Y6 ST14 Suppressor of tumorigenicity 14 protein 0 14740800.0 4908100.0 4427800.0 5404900.0 False True 6722757.206415267 4232165.155223445 4128373.9374096426 1.0 0.6295281869148649 0.6140893997287445 22.680621616643787 LLYSGVPFLGPYHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLYSGVPFLGPYHK 14 0 Q9Y5Y6 Q9Y5Y6 ST14 Suppressor of tumorigenicity 14 protein 0 8220800.0 4240500.0 1507900.0 2472400.0 False True 3526163.636002125 1499776.6434052864 2989367.4089140035 1.0 0.425328146457121 0.8477676357366308 21.7496679955906 -10.35008343357871 6.071938356808286 1.000041133329527 0.6365478910968932 0.49672122606689806 0.17246019932278808 9.604179107338996e-05 1.0279996338552761e-05 0.1670027113772066 0.05566128998839737 4.465977867066047e-11 10.35008343357871 -0.3634932422326337 LLYTFPGWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LLYTFPGWK 9 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 6588900.0 1773000.0 2109800.0 2706100.0 False True 2324420.1697564223 1795026.0639359897 2426098.7307441514 1.0 0.7722468111796207 1.0437436235972708 21.148439447891647 -6.684175594147827 1.8868270824205997 0.8564450857929843 1.0427526963937672 0.3434625235700688 0.09643973315621199 0.4292975662605749 2.958324959512036 0.04095748128792806 0.10745704974271014 2.0693045174591408e-07 6.684175594147827 0.18630761060078294 LLYTFPGWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLYTFPGWK 9 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 6226800.0 1773000.0 2047800.0 2406000.0 False True 2428526.0135234115 1957321.4248309704 1837752.3531254255 1.0 0.8059709527225541 0.7567357083645706 21.21164950941454 -13.999999999999998 0.1925697933270271 2.0495133835240757 0.7223128127068725 0.9994881969574496 0.0023757007650713775 12.393718864926738 0.13916247972488072 4.885101696155176 0.03318055084528898 1.0000000000000041e-14 13.999999999999998 -1.3272005708172032 LLYTFPGWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LLYTFPGWK 9 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 3850320.0 1692000.0 1258900.0 899420.0 False True 1406972.9683093023 1252118.055827914 1087484.563551785 1.0 0.889937535425808 0.7729249872217285 20.424163180158217 -6.970348444404184 0.24972330982251173 1.0372609234933508 0.6221756632972362 0.9999849704998773 0.0003593997390018725 0.07618976714689343 0.008624639070309224 0.0026147144711883654 0.011219612556574226 1.0706599455591376e-07 6.970348444404184 -0.4150852601961146 LLYYVFPYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LLYYVFPYLR 10 0 Q9Y3R5;Q9Y3R5-2 Q9Y3R5 DOPEY2 Protein dopey-2 0 3477330.0 612530.0 1232700.0 1632100.0 False True 838998.8940008449 1178235.2380062204 1246631.5941546166 1.0 1.4043346736581441 1.4858560637785074 19.678309383289577 -12.10200736506696 0.2591671589151433 3.209494843594494e-11 1.518568598486892 0.9994011611024697 0.005198729565920967 5.467590711307401 0.15016583042521298 2.9512925893407536 0.03574623043680795 7.906652192370996e-13 12.10200736506696 1.518568598454797 LMAKPEALK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LMAKPEALK 9 1 Q8IY33;Q8IY33-5;Q8IY33-3 Q8IY33 MICALL2 MICAL-like protein 2 1 81065000.0 16530000.0 13507000.0 51028000.0 True False 21670990.0767477 11491808.249873634 45748112.05513936 1.0 0.5302853357957091 2.1110300864484115 24.369261731172635 -6.827083719479775 1.3408549247071022 0.7484646447148281 2.1510990052643635 0.8999232106237395 0.2096772588985868 0.184436438399447 0.6495292025765311 0.12281449956554055 0.282692638937315 1.4890739994209298e-07 6.827083719479775 1.4026343605495355 up LMALLGQALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LMALLGQALK 10 0 Q2TAY7 Q2TAY7 SMU1 WD40 repeat-containing protein SMU1;WD40 repeat-containing protein SMU1, N-terminally processed 0 8970300.0 2744700.0 2239500.0 3986100.0 False True 3598328.279712613 1905375.3295026277 3573656.609371144 1.0 0.5295168148623738 0.9931435743424055 21.778895380679792 -10.919825742418496 10.626625141518161 1.0335595166907539 0.7613301946023896 0.2610891164775003 0.18927483197102357 0.10260435559527466 0.0007741135907253841 0.12495061466898748 0.06108818933999843 1.2027469314899134e-11 10.919825742418496 -0.27222932208836426 LMALLGQALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMALLGQALK 10 0 Q2TAY7 Q2TAY7 SMU1 WD40 repeat-containing protein SMU1;WD40 repeat-containing protein SMU1, N-terminally processed 0 5197200.0 2029300.0 1365900.0 1802000.0 False True 1964880.982282661 1911310.9930743992 1330002.1411587752 1.0 0.9727362676460801 0.6768868715975214 20.90601049683563 -6.924897274842922 0.787548899291172 1.0054494424968983 0.6233551915161776 0.9954367849133681 0.009883795439246649 0.09537528797057761 0.09130382887673046 0.00874481573917434 0.027558372013756556 1.1887833811778567e-07 6.924897274842922 -0.3820942509807207 LMALLGQALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LMALLGQALK 10 0 Q2TAY7 Q2TAY7 SMU1 WD40 repeat-containing protein SMU1;WD40 repeat-containing protein SMU1, N-terminally processed 0 10724900.0 2744700.0 3655300.0 4324900.0 False True 3759489.76272855 3493796.7595393304 3303447.694111452 1.0 0.9293273768628683 0.878695754637163 21.842105442202683 -6.974733541000676 0.09002632675501399 1.1482641776670455 0.6584819035479922 0.9999998224606879 2.0150311650526168e-05 0.0747942081398675 0.002626210010988989 0.005241833453685589 0.008972044803903366 1.0599038239072463e-07 6.974733541000676 -0.4897822741190533 LMALLGQALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMALLGQALK 10 0 Q2TAY7 Q2TAY7 SMU1 WD40 repeat-containing protein SMU1;WD40 repeat-containing protein SMU1, N-terminally processed 0 4955900.0 2029300.0 1271400.0 1655200.0 False True 1687452.863232901 1264550.7158468594 2001294.6672198933 1.0 0.7493843196450383 1.1859855234034327 20.686415772269907 -6.751028246452335 1.645976474308317 0.8528186673669399 1.1869252416196343 0.6534137940543442 0.1053162257107906 0.2982529970306348 1.5901147433630303 0.05053740050926178 0.12256200193012463 1.7740740916070724e-07 6.751028246452335 0.3341065742526944 LMATMFQNLFPSINVHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMATMFQNLFPSINVHK 17 0 A8MV53;A0A0A6YYI3;A0A0B4J1V8;Q9NQ55-2;Q9NQ55;Q9NQ55-3;C9J3W3 A8MV53 PPAN;PPAN-P2RY11 Suppressor of SWI4 1 homolog 0 21493900.0 6275700.0 7511400.0 7706800.0 False True 6076481.338644497 10510741.19143352 5688157.880955856 1.0 1.7297413759157843 0.9360940261234694 22.53480472444574 -6.664959087408295 1.9553947180187272 1.467791997130888 0.9393707968031413 0.25690236922705434 0.310342182178123 0.4727632093322357 3.4799598047894653 0.12799968714316098 0.3442278855051025 2.1629222716250075e-07 6.664959087408295 -0.5284212003277466 LMATMFQNLFPSINVHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMATMFQNLFPSINVHK 17 0 A8MV53;A0A0A6YYI3;A0A0B4J1V8;Q9NQ55-2;Q9NQ55;Q9NQ55-3;C9J3W3 A8MV53 PPAN;PPAN-P2RY11 Suppressor of SWI4 1 homolog 0 118487000.0 36995000.0 31149000.0 50343000.0 False True 56124119.696779646 25590217.581752174 40392683.983879246 1.0 0.4559575761723799 0.7197027624149434 25.74211757566353 -10.448123775741253 6.16882427378924 1.0001624234576787 0.5878301692936658 0.7650531791732381 0.10767352140159982 0.00024061943713189264 2.152638280902917e-05 0.1042949645018781 0.034751479601325304 3.563495578398547e-11 10.448123775741253 -0.41233225416401287 LMATMFQNLFPSINVHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LMATMFQNLFPSINVHK 17 0 A8MV53;A0A0A6YYI3;A0A0B4J1V8;Q9NQ55-2;Q9NQ55;Q9NQ55-3;C9J3W3 A8MV53 PPAN;PPAN-P2RY11 Suppressor of SWI4 1 homolog 0 11729690.0 786790.0 2653000.0 8289900.0 False True 1077687.525200273 2535781.687702201 6331996.355849725 1.0 2.3529841706490586 5.8755401800471 20.03950749955459 -6.954586342245506 0.5059979150783586 0.9329763082499865 7.449036932714457 0.9995137707347881 0.04531556703105221 0.08169475289868847 0.028733007862516407 0.05256263656420331 0.2906549653581859 1.1102317878012896e-07 6.954586342245506 6.516060624464471 LMATMFQNLFPSINVHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMATMFQNLFPSINVHK 17 0 A8MV53;A0A0A6YYI3;A0A0B4J1V8;Q9NQ55-2;Q9NQ55;Q9NQ55-3;C9J3W3 A8MV53 PPAN;PPAN-P2RY11 Suppressor of SWI4 1 homolog 0 22188200.0 6275700.0 8294000.0 7618500.0 False True 5218522.610649339 8249318.575769899 9211493.126035972 1.0 1.580776628031787 1.7651534377255076 22.315209999880015 -11.241908974808583 0.213019389020126 3.492237578955015e-11 1.889885666939201 0.9993377246152966 0.008390707181545666 3.5099686273645925 0.12073660412060441 1.773617293297875 0.10560383429910782 5.729160977490406e-12 11.241908974808583 1.8898856669042787 LMATMFQNLFPSINVHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LMATMFQNLFPSINVHK 17 0 A8MV53;A0A0A6YYI3;A0A0B4J1V8;Q9NQ55-2;Q9NQ55;Q9NQ55-3;C9J3W3 A8MV53 PPAN;PPAN-P2RY11 Suppressor of SWI4 1 homolog 0 89663000.0 36995000.0 27738000.0 24930000.0 False True 47890756.78047284 26194355.916338343 20392995.803401396 1.0 0.5469605760546037 0.42582321045543625 25.51324389775598 -13.999999999999998 0.1851388780312266 3.3891834382199124 0.3345356473954765 0.9994928318004183 0.0055651526023720544 12.275569594168994 0.13643605847687887 10.564237843034242 0.08664506951393161 1.0000000000000041e-14 13.999999999999998 -3.054647790824436 LMCPQEIVDYIADKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LMCPQEIVDYIADKK 15 1 O14561;H3BNK3 O14561 NDUFAB1 Acyl carrier protein, mitochondrial;Acyl carrier protein 0 6379690.0 858070.0 4584400.0 937220.0 False True 1124938.0795617015 3900425.3898512335 840245.4648490561 1.0 3.4672356289787234 0.7469259687399262 20.101414162084 -6.667926413007651 1.944815776617593 2.5776465369575003 0.7580495984810853 0.26982756165827315 1.0485358147857848 0.4659153948423223 3.395432767625183 0.4343592566959187 1.1636069935355682 2.1481944340292495e-07 6.667926413007651 -1.819596938476415 LMCPQEIVDYIADKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LMCPQEIVDYIADKK 15 1 O14561;H3BNK3 O14561 NDUFAB1 Acyl carrier protein, mitochondrial;Acyl carrier protein 0 5522470.0 858070.0 2011100.0 2653300.0 False True 1175321.6674698463 1922242.9521816429 2026645.1864287988 1.0 1.6355037139064394 1.7243323615326727 20.164624223606893 -11.384078086817746 0.3409694529912682 6.739372902054824e-12 1.7402966183453865 0.9994582642815164 0.007507684940874448 3.63270370375176 0.17533291082267596 2.734116646199801 0.027300378960623033 4.129732420883993e-12 11.384078086817746 1.7402966183386472 LMDEVAGIVAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LMDEVAGIVAAR 12 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 7161500.0 2643600.0 0.0 4517900.0 False True 3465785.2006588127 0.0 4050431.0467569586 1.0 0.0 1.1686907330514915 21.724750812527635 -10.763451207114414 6.168666948188391 1.0144391477137884 0.584345371692051 0.14431705673692852 0.47711599384923037 0.09407993873239173 0.0036076625166906154 0.4587199869209806 0.15398852486560585 1.724045776294659e-11 10.763451207114414 -0.4300937760217374 LMDVGLIAIR ddPTM_RPMI8226_Bortezomib_1h_R1 2 LMDVGLIAIR 10 0 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 54769000.0 17193700.0 20892900.0 16682400.0 False True 22541107.20402763 17775760.759886336 14956265.276880464 1.0 0.7885930623989125 0.6635106759178222 24.426055045672367 LMDVGLIAIR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LMDVGLIAIR 10 0 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 53976800.0 25277800.0 14442400.0 14256600.0 False True 24475370.075368155 20209325.636121046 10522368.771167694 1.0 0.8257005133687263 0.4299166361434238 24.5448273382126 -6.957488790399255 0.4694925023811442 1.010505466266038 0.22890045788960053 0.9996654099807432 0.004362931720785318 0.080610741469121 0.02454096888506045 0.005467152155588855 0.03266739781122332 1.1028366988659288e-07 6.957488790399255 -0.7816050083764374 down LMDVGLIAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMDVGLIAIR 10 0 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 45346200.0 7020000.0 29027000.0 9299200.0 False True 10649853.230744531 23846905.061013848 7461209.044015844 1.0 2.2391768735527173 0.7005926638008918 23.344330212527808 -6.692323031508156 1.8581016657270888 1.7751668155969407 0.7057409618117941 0.38142206746946605 0.5238361332504154 0.41165316635282106 2.7573102706482433 0.22537992797096115 0.5852051596172851 2.0308458905382123e-07 6.692323031508156 -1.0694258537851464 LMDVGLIAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LMDVGLIAIR 10 0 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 78624800.0 17193700.0 29405100.0 32026000.0 False True 23550675.532271557 28105885.452337693 24462118.39617406 1.0 1.1934216245230045 1.0387013469169302 24.48926510719526 -10.192520259609703 6.446795066624635 0.9999992779624522 1.1160614857199669 0.4286612312389645 0.06316428883277452 6.562027953932284e-07 8.227386371550681e-08 0.06115894061387193 0.02038618656036419 6.419182756588228e-11 10.192520259609703 0.11606220775751463 LMDVGLIAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LMDVGLIAIR 10 0 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 39557280.0 25277800.0 8393300.0 5886180.0 False True 21019610.69641186 8348083.626960385 7116953.023378666 1.0 0.39715690968460415 0.3385863385468676 24.325232613646875 -13.999999999999998 0.32966777278212456 7.549229690288763 0.32817314255190827 0.9997141519225963 0.005054289154743879 18.79519638087897 0.18358556541912377 85.33341632987985 0.01879237205552804 1.0000000000000041e-14 13.999999999999998 -7.221056547736854 LMDVGLIAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LMDVGLIAIR 10 0 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 59540900.0 10989300.0 32198300.0 16353300.0 False True 14225865.481488053 30406436.300419558 13377167.199027838 1.0 2.1374050204528565 0.9403411846144183 23.762013090934445 -6.6577407659882315 1.9808120592326004 1.7334950885551557 0.9453462894648967 0.22604710650281612 0.4845450149944916 0.48985028159086436 3.692282437777543 0.1977922822617092 0.5370489181151901 2.1991721853676027e-07 6.6577407659882315 -0.7881487990902589 LMEADK(ub)AQTGQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMEADKAQTGQVK 13 1 P33527-8;P33527-6;P33527-7;P33527-5;P33527-4;P33527-2;P33527-3;P33527;P33527-9;I3L4X2;A0A0A0MS99 P33527-8 ABCC1 Multidrug resistance-associated protein 1 1 2568720.0 561140.0 479380.0 1528200.0 True False 543326.9178525071 670798.9339336745 1127918.5749827076 1.0 1.2346138427762772 2.0759482696730576 19.051460998144616 -6.947386508184033 0.5868342020767056 0.9901797009344233 2.362487656008084 0.9989799112793996 0.014754031780376473 0.08455245779638805 0.04043854919709973 0.01534640217499541 0.07041703104458331 1.128790879772333e-07 6.947386508184033 1.3723079550736608 up LMEEDELPSWIIK(ub)DDAEVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMEEDELPSWIIKDDAEVER 20 1 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8Y4C5;A0A2R8YG32;A0A2R8Y7F3;A0A2R8Y6N0;A0A2R8YF80;A0A2R8YF58;A0A2R8Y526;A0A2R8Y7Y7;A0A2R8Y6V2;A0A2R8YDA1;A0A2R8Y523;A0A2R8Y5K3;K7EQF0;A0A2R8YFK5;P51531;P51531-2;F6VDE0;A0A0U1RQZ9;A0A0U1RRG6 P51532;P51531 SMARCA4;SMARCA2 Transcription activator BRG1;Probable global transcription activator SNF2L2 1 14978700.0 7861600.0 2523200.0 4593900.0 True False 7612037.811222277 3530726.9183141757 3390619.7759541087 1.0 0.4638346532000793 0.445428656562292 22.859851297242912 LMEEDELPSWIIK(ub)DDAEVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMEEDELPSWIIKDDAEVER 20 1 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8Y4C5;A0A2R8YG32;A0A2R8Y7F3;A0A2R8Y6N0;A0A2R8YF80;A0A2R8YF58;A0A2R8Y526;A0A2R8Y7Y7;A0A2R8Y6V2;A0A2R8YDA1;A0A2R8Y523;A0A2R8Y5K3;K7EQF0;A0A2R8YFK5;P51531;P51531-2;F6VDE0;A0A0U1RQZ9;A0A0U1RRG6 P51532;P51531 SMARCA4;SMARCA2 Transcription activator BRG1;Probable global transcription activator SNF2L2 1 33664500.0 8981500.0 13144000.0 11539000.0 True False 13625592.135602832 10798350.505459273 9258311.59227663 1.0 0.7925050447711443 0.6794795778515367 23.699815591534875 -13.99999999999994 0.0738874545391684 2.1653568452540544 0.30018213881022654 0.9999106295925431 0.0012547896344803423 12.320319812489787 0.07465635399208977 2.4196846162813976 0.34731402872940925 1.000000000000139e-14 13.99999999999994 -1.8651747064438278 LMEEDELPSWIIK(ub)DDAEVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMEEDELPSWIIKDDAEVER 20 1 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8Y4C5;A0A2R8YG32;A0A2R8Y7F3;A0A2R8Y6N0;A0A2R8YF80;A0A2R8YF58;A0A2R8Y526;A0A2R8Y7Y7;A0A2R8Y6V2;A0A2R8YDA1;A0A2R8Y523;A0A2R8Y5K3;K7EQF0;A0A2R8YFK5;P51531;P51531-2;F6VDE0;A0A0U1RQZ9;A0A0U1RRG6 P51532;P51531 SMARCA4;SMARCA2 Transcription activator BRG1;Probable global transcription activator SNF2L2 1 17723400.0 7861600.0 6975400.0 2886400.0 True False 6537268.727931688 6937822.135691505 3489932.8947942806 1.0 1.061272287316013 0.5338518332408301 22.64025657267719 -6.877957516990607 1.0910745705023328 1.0370449626640745 0.49789991843848386 0.9720025962994344 0.03940795796151118 0.129457185094347 0.28332040566593436 0.027871084783958475 0.06706615470523743 1.3244710896055756e-07 6.877957516990607 -0.5391450442255907 LMEEIMSEK(ub)ENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LMEEIMSEKENK 12 1 J3KTA4;P17844;P17844-2;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 12204400.0 5297000.0 4054800.0 2852600.0 True False 6944418.29622097 3449839.645486608 2557440.31607138 1.0 0.4967787794931578 0.3682727921880935 22.727422420290345 -13.999999999999998 0.19167011975896078 3.713315257735457 0.2776146289935841 0.9994885760228606 0.006164888599410345 12.378388911668035 0.13883686951815585 12.55092937840283 0.08721562800674415 1.0000000000000041e-14 13.999999999999998 -3.435700628741873 LMEEIMSEK(ub)ENK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LMEEIMSEKENK 12 1 J3KTA4;P17844;P17844-2;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 20891550.0 5511390.0 6207060.0 9173100.0 True False 5336433.941232362 8685571.427390287 6770389.922898766 1.0 1.62759841554124 1.2687105279401725 22.34744455582593 -10.21947674754776 4.627302800911729 0.9999252510374733 1.4481544717321397 0.675230386587698 0.1465153679701128 0.0001656512897940712 2.7941875622094237e-05 0.14189738124042386 0.04728763146689347 6.032860074471787e-11 10.21947674754776 0.4482292206946664 LMEEIMSEK(ub)ENK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMEEIMSEKENK 12 1 J3KTA4;P17844;P17844-2;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 45084600.0 7181600.0 10826000.0 27077000.0 True False 10895012.24528703 8894015.716075927 21725219.081729315 1.0 0.8163382946102979 1.9940518278102186 23.37716448216191 -6.867051807201675 1.1495134486260605 0.8977584172455606 2.0592860040472782 0.9616545869161797 0.1013078321301551 0.13971648912900442 0.3468890703165195 0.06850953784523998 0.1614267797582926 1.358151422374313e-07 6.867051807201675 1.1615275868017176 LMEEIMSEK(ub)ENK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LMEEIMSEKENK 12 1 J3KTA4;P17844;P17844-2;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 15052100.0 5297000.0 4631100.0 5124000.0 True False 7255444.046042596 4426482.689000245 3913816.7320925486 1.0 0.6100912171481252 0.5394317297819006 22.790632481813237 -13.999999999999998 0.24022795158149568 3.5836766359997125 0.5082573475749712 0.9995253392099669 0.004412334234062861 13.631546727340284 0.15512701068900073 16.89771726875606 0.034480938113668265 1.0000000000000041e-14 13.999999999999998 -3.075419288424741 LMEEIMSEK(ub)ENK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LMEEIMSEKENK 12 1 J3KTA4;P17844;P17844-2;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 16667490.0 5511390.0 6262200.0 4893900.0 True False 4582964.9809753 6228464.285650625 5917191.863163023 1.0 1.3590468859147047 1.291127444291269 22.127849831260207 -10.173431536077041 4.815383065240391 0.9999659783214853 1.3250871651043048 0.968299963308397 0.02772799593656783 1.0128656072673033e-05 1.7386340691788849e-06 0.02685032261215463 0.008949172206523925 6.707620199814707e-11 10.173431536077041 0.32512118678281954 LMEEIMSEK(ub)ENK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LMEEIMSEKENK 12 1 J3KTA4;P17844;P17844-2;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 73150100.0 8869000.0 16374400.0 47906700.0 True False 11481095.33412661 15463150.2457456 39188172.16425228 1.0 1.346835802310835 3.41327817806448 23.452756950626746 -6.935983350185403 0.6959231992831315 0.9744270916186649 3.910323987709644 0.9975891097572949 0.05230867216052961 0.08964766908035686 0.06331694112160972 0.049484534412371675 0.18122360762191567 1.1588217817667335e-07 6.935983350185403 2.935896896090979 up LMELFPANK(ub)QSVEHFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMELFPANKQSVEHFTK 17 1 Q7L1Q6-2;Q7L1Q6;Q7L1Q6-4;Q7L1Q6-3;C9IZ80 Q7L1Q6-2 BZW1 Basic leucine zipper and W2 domain-containing protein 1 1 34919200.0 4427700.0 4041500.0 26450000.0 True False 6717144.608228993 3320262.748616378 21222145.906553153 1.0 0.4942967499238908 3.159399885563648 22.679416657239734 -6.857602889981479 1.1978778977948674 0.7272053252915253 3.282611490030866 0.950646731226738 0.25675349758944455 0.14929517082856503 0.40845488541974034 0.16733442460645143 0.3895916549158828 1.3880244300274933e-07 6.857602889981479 2.5554061647393405 up LMELFPANK(ub)QSVEHFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LMELFPANKQSVEHFTK 17 1 Q7L1Q6-2;Q7L1Q6;Q7L1Q6-4;Q7L1Q6-3;C9IZ80 Q7L1Q6-2 BZW1 Basic leucine zipper and W2 domain-containing protein 1 1 39415100.0 4427700.0 9110400.0 25877000.0 True False 5731744.933015269 8603398.231314776 21167651.52044193 1.0 1.501008564034065 3.693055390255542 22.450542979332184 -6.942820155045181 0.6327824846121832 0.9760807535581715 4.336687544036553 0.9985104563553886 0.045134657338233936 0.08650327705432147 0.048925172376474715 0.044938089331799526 0.1864478630357269 1.1407220722577319e-07 6.942820155045181 3.3606067904783816 up LMELHGEGSSSGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LMELHGEGSSSGK 13 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 0 32626860.0 5131850.0 14810210.0 12684800.0 False True 6727905.046906089 12600584.397746408 11372298.577193517 1.0 1.8728838040811744 1.6903179366990635 22.68172591384048 -10.183564103336668 4.731516263573711 0.999892851992181 1.7816008703944088 0.9606890788212439 0.07453220327067218 8.425790829667671e-05 1.453857880982239e-05 0.07217528670531263 0.024055165166513192 6.552935551462689e-11 10.183564103336668 0.7817080184022278 LMELHGEGSSSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMELHGEGSSSGK 13 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 0 21102430.0 5805130.0 2292400.0 13004900.0 False True 5620849.325717512 3207767.2747080754 9598526.551362796 1.0 0.5706908491624793 1.7076648020870986 22.422356711411236 -6.804408032808736 1.4378427941722525 0.7644350383202225 1.7251213879714444 0.8447280202849858 0.18472134840253587 0.21453327739119 0.875106884230133 0.10104636272382177 0.2343951269680019 1.5688880938312835e-07 6.804408032808736 0.9606863496512219 LMELHGEGSSSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMELHGEGSSSGK 13 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 0 55390500.0 1612100.0 52159600.0 1618800.0 False True 2445673.560296761 42851311.85518515 1298843.4704547543 1.0 17.52127207442416 0.5310780193809476 21.221800420298973 -6.55081437147392 2.3837973647960804 9.999999999999998 0.5501114599202319 0.2640493770548046 6.778116515437977 0.5413151485736798 5.7575651446999725 2.629148291738635 8.265597954048902 2.813102965345862e-07 6.55081437147392 -9.449888540079765 LMELHGEGSSSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LMELHGEGSSSGK 13 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 0 23873980.0 4601500.0 8578880.0 10693600.0 False True 6302798.900861804 8199836.71503757 8167991.921605174 1.0 1.3009833954747274 1.2959309110256294 22.5875612016965 -10.039528111156752 4.623835077327182 0.9999892151989922 1.2984571532519913 0.9997851094410058 0.0020626681842153024 1427198.739060311 0.003927307175297347 164.25401377249443 0.0007061061764346818 9.130023362635513e-11 10.039528111156752 0.2984679380529991 LMELHGEGSSSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMELHGEGSSSGK 13 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 0 10290530.0 5805130.0 3112900.0 1372500.0 False True 4827222.805863704 3096130.1898377296 1659483.4042770057 1.0 0.641389534801835 0.3437760118014866 22.202761986845513 -7.589280029514691 0.2318590691738699 1.1614345154881982 2.0155774423378142e-14 0.9998761999195233 0.0029851118650557587 0.13051258724339276 0.025713210966763794 0.03463169164371658 0.07247041244707986 2.5746605017280953e-08 7.589280029514691 -1.161434515488178 down LMELHGEGSSSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LMELHGEGSSSGK 13 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 0 6384000.0 1612100.0 2715600.0 2056300.0 False True 2086895.229241801 2564474.4727957495 1682074.4994197446 1.0 1.2288467752774823 0.8060177031651303 20.992926742391422 -6.7597186214657485 1.6134588608803437 1.1329766434333743 0.8044921794062792 0.6898000107762616 0.09625020547091828 0.2834143247373388 1.454055000595648 0.04706837381220618 0.11314734969421823 1.7389271112815052e-07 6.7597186214657485 -0.3284844640270952 LMELHGEGSSSGK(ub)ATGDETGAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LMELHGEGSSSGKATGDETGAK 22 1 P61247;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 25687560.0 8672930.0 11835500.0 5179130.0 True False 11370295.218773603 10069689.53441766 4643243.309322991 1.0 0.8856137277589328 0.40836611714852294 23.438766377116405 -6.943907493646312 0.6221551499979787 1.005216429803636 0.26338627047992746 0.9986321580450558 0.009476464198055175 0.08602849135646433 0.04682640450056379 0.009524842447013942 0.04042263224489664 1.1378696305118101e-07 6.943907493646312 -0.7418301593237084 down LMELHGEGSSSGK(ub)ATGDETGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMELHGEGSSSGKATGDETGAK 22 1 P61247;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 32106610.0 11022910.0 12160400.0 8923300.0 True False 10672993.755685875 17016111.135648243 6586020.036738132 1.0 1.5943147279162577 0.617073352378711 23.3474615705218 -6.742081267407024 1.6789491330953872 1.3527595020901648 0.6162218345356719 0.6142942685637394 0.24969792496083704 0.3140672903723612 1.7390742940340342 0.11761373038465324 0.2879709807601191 1.8110011770982748e-07 6.742081267407024 -0.7365376675544929 LMELHGEGSSSGK(ub)ATGDETGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMELHGEGSSSGKATGDETGAK 22 1 P61247;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 61461300.0 23132000.0 23650300.0 14679000.0 True False 35092935.175723985 19429719.18436268 11777689.215965735 1.0 0.5536646931090408 0.3356142527545861 25.064677284119373 -10.889607891142163 0.138529207535549 1.9647664286987645 3.398160551384362e-24 0.9997270221783816 0.004568670416372307 3.012671076490005 0.07930265518881083 1.1626995958184847 0.22517368689574035 1.2894131910754132e-11 10.889607891142163 -1.9647664286987645 LMELHGEGSSSGK(ub)ATGDETGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LMELHGEGSSSGKATGDETGAK 22 1 P61247;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 21298630.0 7103730.0 9294900.0 4900000.0 True False 9730170.952084996 8884220.58387605 3742720.918667738 1.0 0.9130590436309164 0.3846510957616569 23.214033721664443 -6.935562936265195 0.6996242549674042 1.0066236502619859 0.25901500575992337 0.997523041846287 0.013532828069108167 0.0898504306656331 0.06427219899173645 0.012766254757804038 0.04643694213833414 1.1599441093840948e-07 6.935562936265195 -0.7476086445020624 down LMELHGEGSSSGK(ub)ATGDETGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LMELHGEGSSSGKATGDETGAK 22 1 P61247;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 34787600.0 12785310.0 16505700.0 5496590.0 True False 10631551.750268672 16416780.517975051 6645901.555639313 1.0 1.5441565731512505 0.6251111513868484 23.341848848007377 -6.746323046010792 1.6637672807027233 1.3213886093568192 0.623820930943696 0.6328417751339543 0.22862805410581336 0.30651613635797526 1.6682345333073085 0.10861426075177423 0.26467964849066883 1.793399126893962e-07 6.746323046010792 -0.6975676784131233 LMELHGEGSSSGK(ub)ATGDETGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LMELHGEGSSSGKATGDETGAK 22 1 P61247;D6RAT0;H0Y9Y4;D6R9B6 P61247 RPS3A 40S ribosomal protein S3a 1 67809400.0 23132000.0 22085800.0 22591600.0 True False 29944829.99988916 20856705.815021466 18480160.609391198 1.0 0.6965043987592738 0.6171402746136679 24.835803606211822 -13.999999999999998 0.18830212127496512 2.6174908268534076 0.5592206836316725 0.9994904308018153 0.00372437859067082 12.323565038920053 0.13760772378840766 7.309703918038609 0.05532582750553243 1.0000000000000041e-14 13.999999999999998 -2.058270143221735 LMEMSK(ub)DSLLGDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LMEMSKDSLLGDK 13 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 20717300.0 3224200.0 5394000.0 12099100.0 True False 4226957.423197219 4589236.225647315 10847201.1947624 1.0 1.0857067545705423 2.5661959912900443 22.011188149956048 -6.918794770745832 0.8336160625176722 0.9658933330789476 2.798443550820927 0.9938395363767855 0.05643037622151312 0.09888618506017106 0.10932696338660318 0.04831274633856976 0.14309366614052862 1.205605524100384e-07 6.918794770745832 1.8325502177419792 up LMEMSK(ub)DSLLGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMEMSKDSLLGDK 13 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 34784300.0 4789000.0 5096200.0 24899100.0 True False 4636975.816366069 7131139.236331918 18377278.753011353 1.0 1.5378857942633155 3.963203493136473 22.144752771839993 -6.942134553029366 0.6393962964614252 0.9734601005722987 4.660462245948855 0.9984303427017119 0.05106598450232558 0.08680617906940243 0.050275246906773714 0.050553145529574205 0.20685874500113902 1.1425243032988951e-07 6.942134553029366 3.6870021453765562 LMEMSK(ub)DSLLGDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMEMSKDSLLGDK 13 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 257138300.0 7276300.0 18109000.0 231753000.0 True False 11038679.068784373 14877307.463737197 185946917.96905175 1.0 1.3477434547225722 16.84503343292949 23.396064208163544 -6.911736496610892 0.8838113415338228 0.5461435227921941 18.924119305130535 0.991561131698822 0.6787615252556779 0.10328046347427146 0.1326149508982037 0.5605309730302824 1.5666148304699385 1.225359447099346e-07 6.911736496610892 18.377975782338343 up LMEMSK(ub)DSLLGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LMEMSKDSLLGDK 13 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 32536600.0 3224200.0 7500300.0 21812100.0 True False 4416273.87072882 7168911.945824661 16660531.214300519 1.0 1.62329424208503 3.7725312564347426 22.07439821147894 -6.948286010252361 0.5773536183363172 0.9740464458304118 4.527601679726124 0.9990598264320893 0.036416066975736766 0.08418137567423206 0.03886759792495197 0.03826465388416518 0.1794103299688457 1.126455370082853e-07 6.948286010252361 3.5535552338957124 LMEMSK(ub)DSLLGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMEMSKDSLLGDK 13 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 40331200.0 4789000.0 8460900.0 27081300.0 True False 3982265.688672135 8415319.452342845 32743874.62021634 1.0 2.1131988948605005 8.222423409206181 21.92515804727427 -6.937751114135325 0.6801633177642921 0.9280276578296691 9.766323361810457 0.9978542557870776 0.14707260092576135 0.08880775894807079 0.05939504526359482 0.14083300521263117 0.531228788642253 1.1541144692769923e-07 6.937751114135325 8.838295703980787 LMEMSK(ub)DSLLGDK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LMEMSKDSLLGDK 13 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 336580500.0 11145200.0 7708100.0 317727200.0 True False 14427681.104736509 7279137.459035536 259904109.75637686 1.0 0.5045258074525812 18.01426770314823 23.78233610489077 -6.900389773721958 0.9588205949673451 0.27977525159092365 19.866696990260117 0.9867586695944391 0.9366663579246318 0.11111824928989103 0.17581479977722977 0.7321508889967214 1.9086413522532808 1.2577960492693812e-07 6.900389773721958 19.586921738669194 up LMEQQGALLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMEQQGALLKR 11 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 6913600.0 2154200.0 2326400.0 2433000.0 True False 2085816.1001494632 3255343.652015732 1795724.3115645403 1.0 1.5607050169870988 0.8609216850113796 20.99218053490099 -6.693357673465191 1.8541396902732612 1.3504242987554083 0.863220796173596 0.3861720087440468 0.23698198256878011 0.40958600147149077 2.7324841910155664 0.10214133364647539 0.26489672403644243 2.0260134610593358e-07 6.693357673465191 -0.4872035025818122 LMEQQGALLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMEQQGALLKR 11 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 6777100.0 2154200.0 3431100.0 1191800.0 True False 1791312.747241075 3412615.9832799714 1440999.8697394077 1.0 1.9050922227489187 0.8044379028501816 20.772585810335265 -6.688227878736279 1.8725885269944422 1.5683870921775562 0.8083146616970669 0.3621028622567326 0.3829317218163482 0.42054403899704335 2.8576996247620032 0.16367136016970057 0.4271856196529676 2.050086195461513e-07 6.688227878736279 -0.7600724304804893 LMEVCK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LMEVCKEK 8 1 A0A087WZK9;B3KS98;O15372;E5RJT0;E5RGU4 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 11994580.0 580880.0 1214700.0 10199000.0 True False 751960.6108566315 1147100.8771928838 8342886.650577239 1.0 1.5254800060419513 11.094845301900913 19.520297567177334 -6.918231452740886 0.8377430349377079 0.7751015577787327 12.57689811683889 0.9936753117990597 0.36899843270834337 0.09922350995854172 0.11109016091406955 0.31498791748360117 0.9281546857441015 1.2071703147412904e-07 6.918231452740886 11.801796559060158 up LMFSGLLVSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LMFSGLLVSSR 11 0 Q9BPX3 Q9BPX3 NCAPG Condensin complex subunit 3 0 6232600.0 1080500.0 1781500.0 3370600.0 False True 1479990.0494145795 1702787.4393673085 2574533.699686013 1.0 1.1505397891295674 1.739561492798136 20.49715604537536 -6.945382523285908 0.6074362048825586 0.9934591920450365 1.9271813005917526 0.9987871979762273 0.011113582879604877 0.08539477903474382 0.044058018634681506 0.011324301302363565 0.049623371331721164 1.1340115468927404e-07 6.945382523285908 0.9337221085467161 LMGEDEK(ub)PAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LMGEDEKPAAK 11 1 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 1 7844600.0 3050400.0 2984500.0 1809700.0 True False 3999103.9401156213 2539224.233489886 1622449.6038681834 1.0 0.634948296296713 0.4057032845766133 21.931245347831712 -8.688973527098385 0.15056540343468192 1.4483883633754746 2.6444520787370102e-16 0.9998786038098778 0.0026963515653181443 0.25217887742201156 0.04155061134713445 0.20480704269579783 0.15599410387990903 2.046569383828259e-09 8.688973527098385 -1.4483883633754744 LMGEDEK(ub)PAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMGEDEKPAAK 11 1 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 1 8168900.0 2588000.0 3821600.0 1759300.0 True False 2505845.3565995786 5347584.809380728 1298486.5521313164 1.0 2.1340442239569715 0.5181830350031484 21.2568659535965 -6.718022833655058 1.7660425771524204 1.691361291516941 0.5209038771652037 0.5033995586166957 0.4773268318805965 0.3591440719323415 2.1879474513070987 0.21467931225768247 0.5402615368299905 1.9141552829169772e-07 6.718022833655058 -1.1704574143517372 LMGEDEK(ub)PAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMGEDEKPAAK 11 1 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 1 20887200.0 7437800.0 10023000.0 3426400.0 True False 11283686.37601589 8234317.339943561 2749170.538155531 1.0 0.7297541836545604 0.24364116890017853 23.427735136873455 -7.096204684360864 0.44002556873498144 1.0186499428540001 4.0905417894675915e-14 0.9997225928931881 0.005212283950877432 0.07602974586391675 0.023256786741631154 0.007214336834515754 0.0388343673431473 8.01300319007681e-08 7.096204684360864 -1.0186499428539593 down LMGEDEK(ub)PAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LMGEDEKPAAK 11 1 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 1 7080700.0 3050400.0 2764400.0 1265900.0 True False 4178215.313960418 2642259.6673516617 966920.4920288756 1.0 0.6323895416598659 0.2314194983676793 21.994455409354604 -7.479193857901841 0.3540482533166926 1.0554516559827702 7.819118862010293e-13 0.999414669776322 0.0075936470352335455 0.11996047098306716 0.03833854921406828 0.019212186013959787 0.06420982540110004 3.317463414515597e-08 7.479193857901841 -1.0554516559819884 down LMGEDEK(ub)PAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LMGEDEKPAAK 11 1 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 1 19943900.0 7437800.0 8705100.0 3801000.0 True False 9628378.720956916 8220653.532602099 3109257.0015534945 1.0 0.8537941610781477 0.32292632972423013 23.198861458965904 -6.947100911334092 0.5898177383821452 1.006139355294273 0.143877161961923 0.9989536562904062 0.009409934529314741 0.08467127803037183 0.04094497549202693 0.009757454438225194 0.04447103443037508 1.1295334292548125e-07 6.947100911334092 -0.86226219333235 down LMGEDEKPAAK(ub)ENSEGAGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMGEDEKPAAKENSEGAGAK 20 2 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 1 15464200.0 5478100.0 6068100.0 3918000.0 True False 5304200.714060332 8491123.974723453 2891758.262519467 1.0 1.6008300651623628 0.5451826615184486 22.33870393823257 -6.752308036336624 1.6411843377614062 1.3523107980870266 0.5426953493761567 0.6588837083249185 0.25250783590564496 0.2960400986028671 1.5695042632559348 0.12150209691498168 0.29427676561705696 1.7688539007996618e-07 6.752308036336624 -0.8096154487108699 LMGEDEKPAAK(ub)ENSEGAGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMGEDEKPAAKENSEGAGAK 20 2 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 1 31154800.0 9783000.0 13917500.0 7454300.0 True False 14841526.233101651 11433813.387076192 5980954.33766424 1.0 0.7703933684107838 0.4029878223928667 23.823136123805504 -6.964161244248517 0.3721736687737605 1.0275666195738753 0.13298208702892966 0.9998947876836185 0.0025220986330034677 0.0782468234859233 0.01587111527328556 0.004827272102228764 0.03116751888150124 1.0860223319007269e-07 6.964161244248517 -0.8945845325449456 down LMGEDEKPAAK(ub)ENSEGAGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LMGEDEKPAAKENSEGAGAK 20 2 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 1 10641390.0 3422700.0 4328190.0 2890500.0 True False 4688164.684989612 4136956.254389672 2207823.4317161427 1.0 0.8824255401341216 0.47093555369013984 22.16059181870139 -6.947945472780973 0.5809638856470375 1.0049011573042301 0.32807333823751544 0.9990300149167276 0.00706444961585819 0.08432142796871106 0.03945900543918026 0.007394001233241419 0.03438318309282259 1.1273389887156361e-07 6.947945472780973 -0.6768278190667147 down LMGEDEKPAAK(ub)ENSEGAGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LMGEDEKPAAKENSEGAGAK 20 2 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 1 30663900.0 9783000.0 14800000.0 6080900.0 True False 12664286.35176013 13976366.98975441 4974238.595302985 1.0 1.1036047828950049 0.39277685746671753 23.594262445897954 -6.869876638600389 1.1346891636037448 1.058557003246546 0.3512342144196469 0.9645629475766646 0.05902187112914178 0.1369762893678485 0.3296861109457753 0.04037001751776107 0.0955614913045946 1.3493461100853836e-07 6.869876638600389 -0.7073227888268989 down LMGLEALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LMGLEALK 8 0 P48643;E7ENZ3;D6RIZ7;H0Y914 P48643 CCT5 T-complex protein 1 subunit epsilon 0 4437620.0 706220.0 2283600.0 1447800.0 False True 925861.2590442081 1942895.7814030822 1297995.544278255 1.0 2.098474001826998 1.4019330991537666 19.82043649526005 -10.174966528304397 4.830323274400567 0.9999357275382444 1.7502035504852314 0.6073336821816653 0.28436163286853366 0.00023773118066175553 4.060519747223878e-05 0.2753602403287655 0.09177732234958635 6.683954297733247e-11 10.174966528304397 0.7502678229469869 LMHK(ub)LSVEAPPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LMHKLSVEAPPK 12 1 P53990-2;P53990;P53990-4;H3BQF7;H3BMU1;H3BUI0;P53990-3;P53990-5;J3KR23 P53990-2 IST1 IST1 homolog 1 12042700.0 3821600.0 4651000.0 3570100.0 True False 5010154.608427047 3957088.929456002 3200700.298817376 1.0 0.7898137360472279 0.638842620432076 22.256423693576863 -6.987967958233739 0.0921561591542532 1.4268428025152273 3.3379289934238835e-07 0.9999998247146199 6.173621742605645e-05 0.07347361338622577 0.002670951576731484 0.015088845029531808 0.026010639046931076 1.0280921468292734e-07 6.987967958233739 -1.426842468722328 LMHK(ub)LSVEAPPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMHKLSVEAPPK 12 1 P53990-2;P53990;P53990-4;H3BQF7;H3BMU1;H3BUI0;P53990-3;P53990-5;J3KR23 P53990-2 IST1 IST1 homolog 1 17500200.0 0.0 7059200.0 10441000.0 True False 0.0 9877975.373241672 7706188.876714086 0.0 LMHK(ub)LSVEAPPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMHKLSVEAPPK 12 1 P53990-2;P53990;P53990-4;H3BQF7;H3BMU1;H3BUI0;P53990-3;P53990-5;J3KR23 P53990-2 IST1 IST1 homolog 1 36291000.0 11131000.0 11963000.0 13197000.0 True False 16886540.78510217 9828109.182654385 10588607.16554942 1.0 0.5820084354591467 0.627044182719235 24.0093704859384 -10.387445460694055 9.027212567495102 1.0000011680395424 0.6045263094023434 0.9903675390828833 0.018385766828693653 4.3221233684661857e-07 2.934164548306457e-08 0.01780199482927464 0.005933980727898609 4.097835677736013e-11 10.387445460694055 -0.395474858637199 LMHK(ub)LSVEAPPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LMHKLSVEAPPK 12 1 P53990-2;P53990;P53990-4;H3BQF7;H3BMU1;H3BUI0;P53990-3;P53990-5;J3KR23 P53990-2 IST1 IST1 homolog 1 12157700.0 3821600.0 4011600.0 4324500.0 True False 5234548.794856786 3834354.2474127915 3303142.1658731927 1.0 0.7325090275555827 0.6310271038295985 22.319633755099755 -13.999999999999998 0.13438290822004303 2.2728756377579047 0.4965137907636095 0.9996262450225529 0.003008781981978354 11.932425186191496 0.11440934920381629 3.9973946238420965 0.11985677515013134 1.0000000000000041e-14 13.999999999999998 -1.7763618469942952 LMHK(ub)LSVEAPPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMHKLSVEAPPK 12 1 P53990-2;P53990;P53990-4;H3BQF7;H3BMU1;H3BUI0;P53990-3;P53990-5;J3KR23 P53990-2 IST1 IST1 homolog 1 12958800.0 0.0 9590300.0 3368500.0 True False 0.0 9538635.150374494 4072837.7758157393 0.0 LMHK(ub)LSVEAPPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LMHKLSVEAPPK 12 1 P53990-2;P53990;P53990-4;H3BQF7;H3BMU1;H3BUI0;P53990-3;P53990-5;J3KR23 P53990-2 IST1 IST1 homolog 1 28267300.0 11131000.0 13643000.0 3493300.0 True False 14409298.92481264 12883755.056839155 2857555.244284879 1.0 0.8941278214898772 0.19831327389316653 23.78049680803085 -6.933939056943586 0.7137172663204067 1.0091928743316263 0.039994760223334515 0.9972573820005799 0.01862282531879214 0.09064347137982671 0.0680340532260499 0.017382975276294062 0.061652532843684264 1.1642893986892516e-07 6.933939056943586 -0.9691981141082918 down LMIEMDGTENK ddPTM_RPMI8226_Bortezomib_1h_R1 3 LMIEMDGTENK 11 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879 P06733 ENO1 Alpha-enolase;Enolase 0 209467600.0 38536900.0 77035300.0 93895400.0 False True 50522249.09187043 65541933.52124749 84180004.71627587 1.0 1.2972885154432663 1.6661967000558837 25.590415529019182 -6.968216655027717 0.2977196259673968 0.9342601015179621 2.0407471619950828 0.9999649373079795 0.0016135470910279197 0.0768857435522196 0.011090500538001136 0.006190604193630011 0.03316656768950273 1.0759283349752674e-07 6.968216655027717 1.1064870604771206 LMIEMDGTENK ddPTM_RPMI8226_Bortezomib_2h_R1 3 LMIEMDGTENK 11 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879 P06733 ENO1 Alpha-enolase;Enolase 0 191011300.0 67504600.0 27085200.0 96421500.0 False True 65361703.42314988 37900461.60745206 71165816.5670039 1.0 0.5798573112773011 1.0887999063653278 25.96194224696238 -6.6874546042681065 1.875511354251619 0.7359679390096568 1.0869855705349891 0.3584857875193894 0.17778428846001096 0.4221797681214631 2.8772043854859004 0.07589021340658311 0.19825609248495682 2.053739687586143e-07 6.6874546042681065 0.3510176315253323 LMIEMDGTENK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMIEMDGTENK 11 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879 P06733 ENO1 Alpha-enolase;Enolase 0 592298700.0 8698000.0 472159700.0 111441000.0 False True 13195501.908976607 387899112.5344263 89414637.5036746 1.0 29.39631362339822 6.776145244073498 23.65354289079995 -9.621774476150867 13.77278546433559 1.0000000000355254 18.086229433825086 0.43205883220532204 9.23464507086405 0.0 0.0 8.941406641898219 2.980468880632739 2.38905156631214e-10 9.621774476150867 17.086229433789562 LMIEMDGTENK ddPTM_RPMI8226_Carfilzomib_1h_R1 3 LMIEMDGTENK 11 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879 P06733 ENO1 Alpha-enolase;Enolase 0 199399500.0 38536900.0 79776900.0 81085700.0 False True 52785033.35056421 76252092.7710704 61934927.672411546 1.0 1.4445779026917174 1.1733425886288567 25.653625590542074 -10.17164221916692 4.363855602114683 0.9999371725758927 1.3089602455893175 0.6337025022647763 0.11073135354464163 8.081644010948398e-05 1.5340657505736264e-05 0.10724113610607443 0.035738390642328324 6.735312968911691e-11 10.17164221916692 0.3090230730134248 LMIEMDGTENK ddPTM_RPMI8226_Carfilzomib_2h_R1 3 LMIEMDGTENK 11 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879 P06733 ENO1 Alpha-enolase;Enolase 0 117304100.0 67504600.0 29487600.0 20311900.0 False True 56133065.86083459 29328744.4459697 24559024.378385503 1.0 0.5224860605098907 0.4375143955128404 25.742347522396656 -13.999999999999998 0.2428148513699858 4.204347192123668 0.4009349113799052 0.9995297214631222 0.005368833476605961 13.72447669844653 0.15594739549696876 21.359404888966385 0.040844617581224 1.0000000000000041e-14 13.999999999999998 -3.803412280743763 LMIEMDGTENK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LMIEMDGTENK 11 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879 P06733 ENO1 Alpha-enolase;Enolase 0 13724000.0 0.0 8108700.0 5615300.0 False True 0.0 7657443.716879837 4593373.01784355 0.0 LMIEMDGTENK(ub)SK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMIEMDGTENKSK 13 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879 P06733 ENO1 Alpha-enolase;Enolase 1 5373550.0 1609800.0 974650.0 2789100.0 True False 1558697.7801599703 1363832.827732604 2058551.0387935287 1.0 0.8749822095676769 1.3206864505717446 20.571909796698307 -6.831840969247372 1.3198447817925683 0.933281882507508 1.3331217485736186 0.9094729220249198 0.056478200426306344 0.17855211001573323 0.6076807234531577 0.03359325804157971 0.07729867686851419 1.4728517352570079e-07 6.831840969247372 0.39983986606611066 LMIEMDGTENK(ub)SK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMIEMDGTENKSK 13 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879 P06733 ENO1 Alpha-enolase;Enolase 1 26936900.0 2988200.0 7703700.0 16245000.0 True False 4533317.866682442 6328914.545717171 13034168.629563564 1.0 1.3960888540888436 2.875194065997006 22.112135892826597 -6.946455373588669 0.5964908952786075 0.9832030928756845 3.3633408413547605 0.9988929436080679 0.02685030040268569 0.08494109100580421 0.04209919832513157 0.027653799343215723 0.1241602123579285 1.1312136224726129e-07 6.946455373588669 2.380137748479076 up LMIEMDGTENK(ub)SK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LMIEMDGTENKSK 13 1 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879 P06733 ENO1 Alpha-enolase;Enolase 1 29289500.0 2988200.0 4760300.0 21541000.0 True False 3868283.8062281106 4495385.120359996 17620759.029324856 1.0 1.1621135742734865 4.555187755602276 21.883262214919046 -6.916859323317636 0.8477000106036084 0.9163296629448334 5.064676934210469 0.9932629801553852 0.13453279725204517 0.10005499395135525 0.1154523825092761 0.11402586729975192 0.33194425297626523 1.2109903340537e-07 6.916859323317636 4.148347271265636 up LMK(ub)AYCER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMKAYCER 8 1 A8MUA9;A8MU27;P55854;P55854-2;P61956-2;P61956 A8MUA9;P61956-2 SUMO3;SUMO2 Small ubiquitin-related modifier 3;Small ubiquitin-related modifier 2 1 22562500.0 3903300.0 1740200.0 16919000.0 True False 5921591.469453717 1429647.7137553412 13574952.234138856 1.0 0.24142964288065455 2.2924499780447 22.497553531753937 -6.806575852148962 1.4289377442828624 0.58488833211185 2.3255714084314656 0.8506921930837577 0.32717896022056603 0.2115013625577828 0.8517774080792302 0.18007414404930333 0.4172204320574207 1.5610763627620608e-07 6.806575852148962 1.7406830763196157 LMK(ub)HDVNLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMKHDVNLGR 10 1 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 2715460.0 378400.0 339660.0 1997400.0 True False 366387.89912568784 475288.00930350035 1474221.0192844262 1.0 1.2972262742237968 4.023661869844399 18.483012330056024 -6.927643861550514 0.7658876493727209 0.9547146170710827 4.551214719982206 0.996054541240018 0.08547150869742391 0.09387977042712643 0.08381059714683156 0.07680400351288208 0.24996760163099294 1.1812889416757232e-07 6.927643861550514 3.5965001029111234 up LMK(ub)HDVNLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMKHDVNLGR 10 1 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 3214500.0 378400.0 1378000.0 1458100.0 True False 314656.36596231675 1370576.4404884174 1762981.9685073267 1.0 4.355788055635771 5.602880345724394 18.2634176054903 -9.124700092292652 0.3612419278148582 1.7266154516125623e-19 5.914161416847484 0.9980541596662869 0.08574155324380216 0.5503129324844473 0.13414349214464777 1.1368585297013454 0.34854391339110063 7.504122373844135e-10 9.124700092292652 5.914161416847484 LMK(ub)YLLEQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LMKYLLEQLK 10 1 Q8N884;Q8N884-2 Q8N884 MB21D1 Cyclic GMP-AMP synthase 1 9114900.0 1136200.0 6396900.0 1581800.0 True False 1489569.2029764517 5442507.454920897 1418130.5096970163 1.0 3.6537459582580647 0.9520407020119059 20.506463719747288 -6.650337023465823 2.0077923887700124 2.7216524308928784 0.9635329707292759 0.19515918740724414 1.1325751987547155 0.5077671426140777 3.9240519457977965 0.45746989529582627 1.2541327672444904 2.2369845084517761e-07 6.650337023465823 -1.7581194601636025 LMK(ub)YLLEQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMKYLLEQLK 10 1 Q8N884;Q8N884-2 Q8N884 MB21D1 Cyclic GMP-AMP synthase 1 45431000.0 14875000.0 12985500.0 17570500.0 True False 22566462.508165937 10668136.068825414 14097682.973576285 1.0 0.4727429505162816 0.6247183389277284 24.427676945305915 -10.685539841656702 10.18762428843652 1.0002823799751308 0.5487306447220336 0.9216062370545764 0.062043692511554734 0.00039816145987689683 1.2289979472894571e-05 0.06010849936866791 0.020024515652872114 2.062814418500829e-11 10.685539841656702 -0.4515517352530972 LMK(ub)YLLEQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LMKYLLEQLK 10 1 Q8N884;Q8N884-2 Q8N884 MB21D1 Cyclic GMP-AMP synthase 1 12214500.0 1136200.0 2984800.0 8093500.0 True False 1556283.8446504807 2852921.6665863297 6181981.990864765 1.0 1.8331628104942872 3.972271518537257 20.56967378127018 -6.954889004192227 0.5023185692955672 0.9580078510861841 4.940051628209312 0.9995311693018352 0.027105860973039655 0.08158005721905032 0.028282968800425565 0.031651270128405316 0.17647230178625903 1.1094583313870424e-07 6.954889004192227 3.9820437771231276 LMK(ub)YLLEQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMKYLLEQLK 10 1 Q8N884;Q8N884-2 Q8N884 MB21D1 Cyclic GMP-AMP synthase 1 15088400.0 3206400.0 8169000.0 3713000.0 True False 2666263.6676045754 8124991.975580447 4489371.133027708 1.0 3.0473325178976403 1.6837686338279698 21.346388025346112 -10.169114460172038 4.788728206175404 0.9999454470422928 2.3655505758537823 0.5721415247677597 0.5566726269932335 195071935.34205955 84.56200002350458 308337.01743778103 0.19056384646308847 6.774629358197711e-11 10.169114460172038 1.3656051288114894 LMK(ub)YLLEQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LMKYLLEQLK 10 1 Q8N884;Q8N884-2 Q8N884 MB21D1 Cyclic GMP-AMP synthase 1 50198000.0 21111200.0 13338800.0 15748000.0 True False 27328864.563965954 12596484.054252451 12882025.588125356 1.0 0.4609223345071331 0.4713706842073032 24.703922185471704 -10.019546508921596 5.255800354798669 1.0000037527901537 0.466146509355703 0.9997127972872482 0.004265520908559885 1.8756950166456913e-07 3.498852651926159e-08 0.004130101836135675 0.0013766909527158358 9.559903118187004e-11 10.019546508921596 -0.5338572434344507 LMLELGFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMLELGFSK 9 0 P31350;P31350-2;A0A286YFD6;C9JXC1;A0A2R8Y837 P31350 RRM2 Ribonucleoside-diphosphate reductase subunit M2 0 55218000.0 14166000.0 21141000.0 19911000.0 False True 21490857.673322897 17368223.374613103 15975582.122698674 1.0 0.8081679958344652 0.7433664289038374 24.35721972428568 -13.999999999999998 0.15155253252802975 1.9298755209676164 0.6733289120569044 0.999561137948973 0.002282695816819424 11.963895023996544 0.12268250316445171 3.2747135797981044 0.06322476692102849 1.0000000000000041e-14 13.999999999999998 -1.256546608910712 LMLELGFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMLELGFSK 9 0 P31350;P31350-2;A0A286YFD6;C9JXC1;A0A2R8Y837 P31350 RRM2 Ribonucleoside-diphosphate reductase subunit M2 0 5333360.0 3198600.0 958460.0 1176300.0 False True 2659777.6220059902 953296.5857405857 1422258.8914033114 1.0 0.3584121386139095 0.5347284974638786 21.342874199621896 -10.804970251513522 10.763829926254466 1.0044034736770204 0.44657031803953023 0.9292609421545841 0.07198085208131288 0.007576710131925838 0.00013728206406838877 0.06942276348790018 0.023231720113062022 1.566858393759049e-11 10.804970251513522 -0.5578331556374903 LMLELGFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LMLELGFSK 9 0 P31350;P31350-2;A0A286YFD6;C9JXC1;A0A2R8Y837 P31350 RRM2 Ribonucleoside-diphosphate reductase subunit M2 0 84578600.0 23605600.0 32661400.0 28311600.0 False True 30557914.535940804 30843764.378321927 23159179.30154747 1.0 1.0093543635657767 0.7578782666699561 24.865042752371856 -6.898261045904959 0.9722122338304416 1.0109601559302834 0.7323958109675258 0.9856806301237521 0.013929410873879241 0.11269608024934735 0.18473399023615553 0.010780081512278676 0.027810570527737173 1.2639763676570703e-07 6.898261045904959 -0.2785643449627576 LMMWK(ub)ETGGVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LMMWKETGGVEK 12 1 O60216 O60216 RAD21 Double-strand-break repair protein rad21 homolog 1 17439500.0 3501800.0 6322500.0 7615200.0 True False 4590893.711479434 5379207.644911972 6827252.154156491 1.0 1.171712521128811 1.4871292134437986 22.13034360043858 -6.9616741507916515 0.41116304162814993 0.9846580198203203 1.6859112741188367 0.9998273305922296 0.002650847570545636 0.07910846530416678 0.018961253523719853 0.004062953273111089 0.026325091989395234 1.0922595465405402e-07 6.9616741507916515 0.7012532542985164 LMMWK(ub)ETGGVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMMWKETGGVEK 12 1 O60216 O60216 RAD21 Double-strand-break repair protein rad21 homolog 1 27538600.0 4350700.0 6933900.0 16254000.0 True False 4212589.409952776 9702642.42981081 11996589.790452126 1.0 2.3032490199227795 2.847794698934737 22.006275876372754 -9.610102119257007 0.24353471603317417 1.366099668238085e-14 3.19513951153867 0.9991377204522763 0.022765366316924024 1.0204494221486287 0.10040897674312244 1.0084732157399312 0.24785862052473706 2.4541317875105357e-10 9.610102119257007 3.195139511538656 LMMWK(ub)ETGGVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMMWKETGGVEK 12 1 O60216 O60216 RAD21 Double-strand-break repair protein rad21 homolog 1 22695100.0 4350700.0 8295400.0 10049000.0 True False 3617799.818689882 8250711.033692015 12150199.438673683 1.0 2.2805880499711715 3.358449899827141 21.78668115180703 -6.973116046440561 0.16780837040161356 0.019109118793627904 5.648734440021431 0.9999976050443664 0.001491868920148511 0.07530389302655187 0.00522214670589986 0.04635218363388819 0.12580816867106315 1.0638587099555222e-07 6.973116046440561 5.629625321227803 LMMWK(ub)ETGGVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LMMWKETGGVEK 12 1 O60216 O60216 RAD21 Double-strand-break repair protein rad21 homolog 1 79861200.0 13445200.0 19213000.0 47203000.0 True False 17405076.444514498 18143779.660415623 38612538.34368048 1.0 1.042441825421223 2.2184641628419777 24.053004814721266 -6.914543799620997 0.8642161801288814 0.9686091845039598 2.386198331000075 0.992526327797561 0.048814374259605935 0.10148951688345427 0.12303518645118666 0.04088552687547193 0.11675337325420362 1.2174642025223077e-07 6.914543799620997 1.4175891464961152 up LMNESLMLVTALNPHIGYDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMNESLMLVTALNPHIGYDK 20 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 13758800.0 7297200.0 3174200.0 3287400.0 False True 7065554.380285339 4441674.6132343225 2426331.3201139607 1.0 0.6286378073357843 0.343402822980746 22.75237133162584 -7.783593828544781 0.21768462884467146 1.19897649999071 7.978370052318124e-18 0.9998487034492562 0.003306580495012749 0.1255822381722129 0.030814676106703822 0.05262693774358985 0.0873545700781805 1.6459103319340115e-08 7.783593828544781 -1.19897649999071 down LMNESLMLVTALNPHIGYDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMNESLMLVTALNPHIGYDK 20 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 14215200.0 7297200.0 3252300.0 3665700.0 False True 6067945.120772252 3234779.2143689957 4432180.921718195 1.0 0.5330930240775338 0.7304253472144328 22.532776607060118 -10.233627136030345 5.527060813096563 1.0000213964881555 0.6317591856459641 0.8227917935972561 0.08056058357396946 2.124154791486523e-05 2.9453482119962455e-06 0.07800697583453466 0.02600081654521803 5.839462367552266e-11 10.233627136030345 -0.36826221084219135 LMNTGK(ub)QHTFVETESVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LMNTGKQHTFVETESVR 17 1 P48444;B0YIW6;Q6P1Q5 P48444 ARCN1 Coatomer subunit delta 1 10392900.0 4734100.0 4230200.0 1428600.0 True False 6206450.945089617 3599070.6491904533 1280782.1760988492 1.0 0.5798919029623435 0.20636305473616462 22.56533709258612 -7.77029324088599 0.3341031648370928 1.0820423514486504 1.3782235212174781e-19 0.9991005254039357 0.009722765537771069 0.11862878100330283 0.05314500969483476 0.03634345489579417 0.07993724304082073 1.6970973648483685e-08 7.77029324088599 -1.0820423514486504 down LMNTGK(ub)QHTFVETESVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMNTGKQHTFVETESVR 17 1 P48444;B0YIW6;Q6P1Q5 P48444 ARCN1 Coatomer subunit delta 1 50468200.0 10242400.0 3052800.0 37173000.0 True False 15538469.619740404 2508003.9883647324 29825740.256495308 1.0 0.16140611332653446 1.9194773350526135 23.88934108425484 -6.7770066558046755 1.5476455354016265 0.5233225600453429 1.9320910799358106 0.7566205062778789 0.3542060579696229 0.2552522495472297 1.2073909040434956 0.180305002502855 0.426501156829351 1.6710650041131137e-07 6.7770066558046755 1.4087685198904678 LMNTGK(ub)QHTFVETESVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMNTGKQHTFVETESVR 17 1 P48444;B0YIW6;Q6P1Q5 P48444 ARCN1 Coatomer subunit delta 1 11655900.0 2887700.0 6583300.0 2184900.0 True False 2401250.4968006946 6547834.456217258 2641752.488163813 1.0 2.7268435612782853 1.1001569772431286 21.195354481697777 -6.63210408258399 2.0724203704778503 2.135947606665788 1.1067210899477569 0.1250836265990507 0.7403371365496999 0.5536961044678196 4.534439801219671 0.2918708858713781 0.8202287703124236 2.3328988950478768e-07 6.63210408258399 -1.0292265167180312 LMNTGK(ub)QHTFVETESVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LMNTGKQHTFVETESVR 17 1 P48444;B0YIW6;Q6P1Q5 P48444 ARCN1 Coatomer subunit delta 1 37511800.0 10242400.0 9018400.0 18251000.0 True False 13258988.707887966 8516518.11218926 14929505.271074148 1.0 0.642320338286634 1.1259912501616633 23.66046740634729 -6.708617352854573 1.800181004361635 0.7797949426145424 1.1248065683747561 0.4584981708530962 0.1507574198149133 0.37786817429856046 2.386173610780874 0.06666656002984828 0.16964593650020113 1.9560621393154636e-07 6.708617352854573 0.3450116257602137 LMQDLDNNSITVK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMQDLDNNSITVKQR 15 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;H0YBA1 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 37858900.0 26716000.0 5223000.0 5919900.0 True False 40530125.2012209 4290914.842514743 4749829.170215654 1.0 0.1058697652970854 0.11719256100577193 25.272491296218583 -10.009143085522306 4.935378373193244 1.0000112882800358 0.11153116313954792 0.9998782042889465 0.004622512036186095 3576678.3275564048 1116128.6750426271 435.81908399516635 0.0015824089097211274 9.791673293377135e-11 10.009143085522306 -0.8884801251404879 LMQDLDNNSITVK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LMQDLDNNSITVKQR 15 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;H0YBA1 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 18124200.0 7626100.0 8206900.0 2291200.0 True False 10445675.25760343 7844292.021410918 1750065.7487452093 1.0 0.7509607400154471 0.1675397430598211 23.316402422227565 -7.15566695932687 0.5532623448474031 1.005481647615971 7.727934872776661e-22 0.9988805399824515 0.01167259746263429 0.08214556902515628 0.041574591898381384 0.012213794603816023 0.04770213491949543 6.987680520866109e-08 7.15566695932687 -1.005481647615971 down LMQDLDNNSITVK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMQDLDNNSITVKQR 15 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;H0YBA1 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 18245200.0 10006000.0 6855500.0 1383700.0 True False 8320432.340959142 6818568.060789792 1673025.2724940553 1.0 0.8194968460020886 0.20107431969108427 22.98822706403097 -6.9759600434257925 0.5880947068946494 1.0064324383910797 1.3957680220097278e-19 0.9990714465794828 0.010424620175416873 0.07952151902062679 0.03912765989350983 0.010992700189690882 0.04849654343457259 1.0569147445034333e-07 6.9759600434257925 -1.0064324383910797 down LMQDLDNNSITVK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LMQDLDNNSITVKQR 15 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;H0YBA1 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 39618800.0 26716000.0 7671900.0 5230900.0 True False 34584388.65109107 7244952.020857892 4278929.873566477 1.0 0.20948619603918683 0.1237243172558288 25.043617618311032 -13.999999999999998 0.31367320899534923 8.807828989873643 0.10546970803964593 0.9996800396701065 0.007055215216390172 17.5354488740179 0.1783431924200064 89.54195871988345 0.029279276981577437 1.0000000000000041e-14 13.999999999999998 -8.702359281833997 LMQITSLHSLNAFLLPIK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LMQITSLHSLNAFLLPIK 18 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 524148200.0 235541000.0 173706200.0 114901000.0 False True 228063879.88362473 243067991.52586585 84804981.14388709 1.0 1.065789074753518 0.37184748934009604 27.764862733854624 -6.883662543463635 1.0591216031880666 1.0431449349858954 0.3190710700665588 0.9765232677103534 0.04792388985416942 0.12443701487386531 0.2530794887932147 0.03473212651792722 0.08483293543307559 1.3071862065687992e-07 6.883662543463635 -0.7240738649193366 down LMQITSLHSLNAFLLPIK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LMQITSLHSLNAFLLPIK 18 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 573164000.0 159820000.0 194299000.0 219045000.0 False True 242458624.40706396 159624825.38498396 175750659.7391657 1.0 0.6583590324961579 0.7248686664331552 27.853163331323582 -10.770951050585884 7.021760506484238 1.0075992017254918 0.6916138494649178 0.9662907951100774 0.027152444354156462 0.0032605952028652465 0.00010636006164688346 0.026537905660384883 0.008763413732705965 1.6945287803473542e-11 10.770951050585884 -0.315985352260574 LMQITSLHSLNAFLLPIK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LMQITSLHSLNAFLLPIK 18 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 179785200.0 45282100.0 23436100.0 111067000.0 False True 62024116.072740264 22400615.609181117 84835262.09666729 1.0 0.36115977183633313 1.36777865559865 25.886325934126727 -6.735252918664023 1.704388641213082 0.6178102392457461 1.3677428817921533 0.5833151122058858 0.26845991037891537 0.326472276290075 1.8602717674664992 0.12471273193596567 0.3076061487196671 1.839700309158487e-07 6.735252918664023 0.7499326425464072 LMQITSLHSLNAFLLPIK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LMQITSLHSLNAFLLPIK 18 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 796091200.0 235541000.0 244913000.0 315637200.0 False True 195862777.7355444 243593605.05757573 381635479.1784794 1.0 1.2436952435468769 1.9484839518296164 27.5452680092889 -6.952271443976875 0.5333269816766412 0.9891432497181776 2.2352131209658874 0.9993676781318935 0.01011321246958992 0.08258632107575863 0.03228564565555315 0.011228229384838423 0.058308291982441446 1.116165400832947e-07 6.952271443976875 1.2460698712477098 LMQITSLHSLNAFLLPIK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LMQITSLHSLNAFLLPIK 18 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 457113800.0 159820000.0 176717800.0 120576000.0 False True 206890140.52318355 166883299.08256894 98632405.21423689 1.0 0.8066276075822397 0.4767380647759017 27.62428965341603 -6.963031145795778 0.39037349058197873 1.0201764951691505 0.25132886332480525 0.999866626998214 0.0024948710595022188 0.07863560993459703 0.017256568237443235 0.004258362477435244 0.027745317155412147 1.0888520025917752e-07 6.963031145795778 -0.7688476318443453 down LMSAISK(ub)TFCPAHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LMSAISKTFCPAHK 14 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 11366670.0 3856770.0 4222500.0 3287400.0 True False 4992664.793302453 3987514.163124192 2689126.9315724685 1.0 0.7986745211641991 0.538615557603601 22.251378616934637 -6.967622021579895 0.30976587184131094 1.0401751694196846 0.28885118495785306 0.9999574431356755 0.0012320750266382346 0.07708210468039656 0.011778066588872697 0.00411901506519577 0.023093520394700227 1.0774024986951016e-07 6.967622021579895 -0.7513239844618316 LMSNLDSNR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LMSNLDSNR 9 0 P26447 P26447 S100A4 Protein S100-A4 0 17348380.0 6374100.0 1846480.0 9127800.0 False True 6171757.684505946 2583789.093265995 6736955.351869631 1.0 0.41864720317074944 1.0915780716379389 22.557249989265184 -6.678191086991136 1.9084095042534084 0.6315695297443357 1.0889745410738019 0.3157886861672765 0.2464903160924579 0.44257443965528154 3.114825826777248 0.10370146530571053 0.2741315735154415 2.098016565690292e-07 6.678191086991136 0.4574050113294662 LMSSLPNFCGIFNHLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LMSSLPNFCGIFNHLER 17 0 Q96PU8-9;Q96PU8-8;Q96PU8-6;Q96PU8;Q96PU8-5;Q96PU8-3;H0YFB7 Q96PU8-9 QKI Protein quaking 0 2788840.0 1921600.0 512560.0 354680.0 False True 2519236.2088008733 436088.04594323196 317981.1159307989 1.0 0.17310327805696502 0.12622123912793162 21.264554967811232 -13.444598206297236 0.4139364808611868 9.999946244560348 0.1242813120670195 0.999846577284934 0.004970776312882738 17.949348046529124 0.21314211053694773 143.31648891703355 0.011558464019917893 3.59254150019291e-14 13.444598206297236 -9.87566493249333 LMSSLPNFCGIFNHLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMSSLPNFCGIFNHLER 17 0 Q96PU8-9;Q96PU8-8;Q96PU8-6;Q96PU8;Q96PU8-5;Q96PU8-3;H0YFB7 Q96PU8-9 QKI Protein quaking 0 15252400.0 7121900.0 4429400.0 3701100.0 False True 6895819.1828309605 6198082.519015846 2731670.879379992 1.0 0.898817436287726 0.3961343543028562 22.717290514944175 -6.939948657072506 0.6600452250715734 1.0056474505235893 0.26078314812767794 0.998157109714605 0.011336099202146732 0.08779018288335678 0.05471729878972124 0.011030513586233196 0.04327476181866558 1.1482893659175152e-07 6.939948657072506 -0.7448643023959114 down LMSSLPNFCGIFNHLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LMSSLPNFCGIFNHLER 17 0 Q96PU8-9;Q96PU8-8;Q96PU8-6;Q96PU8;Q96PU8-5;Q96PU8-3;H0YFB7 Q96PU8-9 QKI Protein quaking 0 6975900.0 1921600.0 1020500.0 4033800.0 False True 2632067.4492874197 975410.935657783 3081099.518718757 1.0 0.3705873631474969 1.170600517685405 21.327765029334124 -6.696947813551644 1.8419757290635654 0.6079846844737772 1.1680694312349291 0.4029594297322101 0.2658359711793039 0.4019304159761801 2.649092762663355 0.11523646079895605 0.2974550273722662 2.009334247216716e-07 6.696947813551644 0.5600847467611519 LMSSLPNFCGIFNHLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMSSLPNFCGIFNHLER 17 0 Q96PU8-9;Q96PU8-8;Q96PU8-6;Q96PU8;Q96PU8-5;Q96PU8-3;H0YFB7 Q96PU8-9 QKI Protein quaking 0 15393500.0 7121900.0 1889600.0 6382000.0 False True 5922175.403665493 1879420.3497437646 7716446.692966012 1.0 0.31735303695674216 1.302975033159262 22.49769579037845 -6.720381239242326 1.7579579280979563 0.5848713618526935 1.3014759257263189 0.5144134726498354 0.28724436147566007 0.3545245098635816 2.141425030564777 0.1297302191156556 0.32552365026158364 1.9037887702918054e-07 6.720381239242326 0.7166045638736254 LMTQMAQAK(ub)EQLDTSNESAEPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LMTQMAQAKEQLDTSNESAEPK 22 1 Q96DX7 Q96DX7 TRIM44 Tripartite motif-containing protein 44 1 6421100.0 6421100.0 0.0 0.0 True False 8418124.28202086 0.0 0.0 1.0 0.0 0.0 23.00506737856736 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 LMTQMAQAK(ub)EQLDTSNESAEPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMTQMAQAKEQLDTSNESAEPK 22 1 Q96DX7 Q96DX7 TRIM44 Tripartite motif-containing protein 44 1 5802600.0 1972000.0 2282100.0 1548500.0 True False 1639805.374412495 2269805.874338616 1872284.1905449494 1.0 1.384192239979599 1.1417722003842965 20.645093163416178 -10.278482448324112 5.143374122384343 0.9999488449927431 1.2629822201819998 0.6107607400534398 0.09896756673916926 5.8065654859585585e-05 8.145477631887608e-06 0.0958435379637695 0.03194164481626002 5.2664449839425753e-11 10.278482448324112 0.26303337518925674 LMVAEK(ub)NGTIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMVAEKNGTIR 11 1 Q8NFH4 Q8NFH4 NUP37 Nucleoporin Nup37 1 20586800.0 6335300.0 7407500.0 6844000.0 True False 6134189.3692679005 10365353.379602192 5051351.084401033 1.0 1.6897674257551116 0.8234749174370367 22.548441274221677 -6.694600154557346 1.850148311326126 1.4305673412903999 0.8262996855282965 0.39198010874801426 0.2914572551767508 0.4068678920597041 2.7037040796502767 0.1258611218549731 0.3258539676741702 2.020225485197878e-07 6.694600154557346 -0.6042676557621034 LMVALAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LMVALAK 7 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 37044360.0 8075960.0 11884500.0 17083900.0 False True 10587661.767707877 10111378.925418157 15316221.908340417 1.0 0.9550152949027545 1.4466104267756776 23.335880676714655 -6.884531061015334 1.0541671496816964 0.9700205011110002 1.4846296204763394 0.9771618025116264 0.033533984595457526 0.12369384051634755 0.2486537550163621 0.024395260707684777 0.05973728600774406 1.3045746613004268e-07 6.884531061015334 0.5146091193653392 LMVALAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMVALAK 7 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 15613300.0 4067300.0 2253600.0 9292400.0 False True 3938185.7878274545 3153474.232368743 6858441.673975473 1.0 0.8007428806725732 1.741523138693518 21.909099742741095 -6.8513694090068205 1.2285642814472437 0.8935373003612733 1.7801154739581704 0.9422600945442496 0.09726530143276402 0.15595907990753974 0.4523158325021637 0.061929808918853135 0.14343146435344833 1.4080905731437469e-07 6.8513694090068205 0.8865781735968971 LMVALAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMVALAK 7 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 48677200.0 5272200.0 23781000.0 19624000.0 False True 7998312.849448899 19537094.748198923 15745307.79849524 1.0 2.4426519837299274 1.968578635878206 22.9312642817702 -10.198405840387686 6.3487829859464995 0.9999901812626181 2.205615309804068 0.8960837561886189 0.19353963381495096 2.689861658770006e-05 3.3955454177209625e-06 0.1873954653831622 0.0624646482163648 6.332776480836939e-11 10.198405840387686 1.2056251285414499 LMVALAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LMVALAK 7 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 44196760.0 8075960.0 9721000.0 26399800.0 False True 11061860.656612815 9291494.076951781 20164710.960947867 1.0 0.8399576134054172 1.8229040834005932 23.399090738237547 -6.865138366142869 1.1594336592696486 0.9116603185424046 1.8754088301794063 0.9595894318445819 0.08656658539858714 0.1416054439119846 0.3588364387974409 0.058097167906978324 0.13650720828122648 1.3641484498992636e-07 6.865138366142869 0.9637485116370017 LMVALAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMVALAK 7 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 12784700.0 4067300.0 3371800.0 5345600.0 False True 3382140.161941146 3353635.4441501037 6463340.244738198 1.0 0.9915719880234998 1.9110208138235842 21.68950501817537 -6.904831368074298 0.9302151871226814 0.9666723991768976 2.0175901358161528 0.9888204140993471 0.0456197543576091 0.10793633986154005 0.15804148381987265 0.03642006819676391 0.09727573269628599 1.2449979373804382e-07 6.904831368074298 1.050917736639255 LMVALAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LMVALAK 7 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YNA0;H0YN52 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 42509200.0 5272200.0 23997000.0 13240000.0 False True 6824966.830598978 22661545.85494167 10830455.853872217 1.0 3.320389156082218 1.5868876908404999 22.70239060386265 -6.571755170472175 2.300124658040436 2.5879302203213483 1.590658103179711 0.0 1.010157997879978 0.7244390331287153 7.197639873972273 0.37076874527538944 1.1313996998262374 2.68067910717515e-07 6.571755170472175 -0.9972721171416374 LMVMEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LMVMEIR 7 0 Q06323;Q06323-3;Q06323-2;H0YKK6 Q06323 PSME1 Proteasome activator complex subunit 1 0 13071200.0 4131100.0 4910000.0 4030100.0 False True 5415912.105629314 4177447.1390300933 3613103.9114489504 1.0 0.771328459095199 0.667127501514192 22.368772895053617 -13.99999999946074 0.10578575162374446 2.1126201365727435 0.4638323080817772 0.9997644846633655 0.0021335470825410282 12.039118371161038 0.09798108068678753 2.8850546940278656 0.18081068124754987 1.0000000012416904e-14 13.99999999946074 -1.6487878284909663 LMVMEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LMVMEIR 7 0 Q06323;Q06323-3;Q06323-2;H0YKK6 Q06323 PSME1 Proteasome activator complex subunit 1 0 11399800.0 4131100.0 3239600.0 4029100.0 False True 5658479.308779799 3096463.760075408 3077509.561919218 1.0 0.5472254277347764 0.5438757294992841 22.43198295657651 LMVPVTVVFTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LMVPVTVVFTR 11 0 Q96S52-2;Q96S52 Q96S52-2 PIGS GPI transamidase component PIG-S 0 3202200.0 1008800.0 1160700.0 1032700.0 False True 1322546.569233097 987528.084373164 925846.110357889 1.0 0.746686814170786 0.7000480224259763 20.334887092433817 -13.999999999999998 0.23798091581657108 2.6604376358511987 0.6790277892315971 0.9995216693084592 0.0028823110554114214 13.552947459564606 0.1544100396157383 10.682002741834015 0.023062910292202476 1.0000000000000041e-14 13.999999999999998 -1.9814098466196017 LMVYNSK(ub)SDSCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMVYNSKSDSCR 12 1 G3V0G1;Q9BQQ3-2;Q9BQQ3;B4E1H8;Q9BQQ3-3 G3V0G1 GORASP1 Golgi reassembly-stacking protein 1 1 15360900.0 1432100.0 4290200.0 9638600.0 True False 2172600.400534077 3524580.2905144063 7733526.485251547 1.0 1.6222864957808072 3.559571508571232 21.050991417943003 -6.950615190716755 0.5520474540512276 0.9735273783410249 4.2996618135691875 0.9992486879212445 0.029875330006988356 0.08323963231427298 0.03494712236207772 0.032341336469334826 0.16077730247212313 1.1204302078165209e-07 6.950615190716755 3.3261344352281625 LMVYNSK(ub)SDSCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LMVYNSKSDSCR 12 1 G3V0G1;Q9BQQ3-2;Q9BQQ3;B4E1H8;Q9BQQ3-3 G3V0G1 GORASP1 Golgi reassembly-stacking protein 1 1 2760670.0 977240.0 751030.0 1032400.0 True False 1338552.0369180043 717847.0112759073 788568.3829454222 1.0 0.5362862193454496 0.5891204534424295 20.352241794925405 -10.3514227171196 5.547749287692021 1.0001103132378404 0.5627033363955923 0.9891704371188152 0.021569485748075663 2.9437376657479078e-05 3.441426156036138e-06 0.020889791298886937 0.006961521590710607 4.452226834295664e-11 10.3514227171196 -0.43740697684224805 LMVYNSK(ub)SDSCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LMVYNSKSDSCR 12 1 G3V0G1;Q9BQQ3-2;Q9BQQ3;B4E1H8;Q9BQQ3-3 G3V0G1 GORASP1 Golgi reassembly-stacking protein 1 1 14080500.0 1432100.0 4099000.0 8549400.0 True False 1853881.6809113445 3870887.046689415 6993496.924251892 1.0 2.087990342936307 3.772353433480166 20.822117740035452 -6.964726878299388 0.3627088870139128 0.8592767579690894 5.059032040634237 0.9999074046758245 0.010974665780113649 0.07805375982106873 0.015187462146478179 0.022478687215044476 0.1436361684183263 1.0846087948253563e-07 6.964726878299388 4.199755282665147 LMWIPDTK(ub)GVYPDLLATSGDYLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LMWIPDTKGVYPDLLATSGDYLR 23 1 P61962 P61962 DCAF7 DDB1- and CUL4-associated factor 7 1 29744100.0 23110000.0 3077800.0 3556300.0 True False 22376385.699774414 4306781.590514967 2624798.3432868808 1.0 0.19246993899280104 0.11730215855697118 24.415473690958983 -13.984674473104032 0.3358513779537158 9.999999999993603 0.10482008152422516 0.9997262561845215 0.006610976190463353 19.116121847504846 0.18549944718031133 121.8340266493108 0.023587729174748592 1.0359183518468797e-14 13.984674473104032 -9.895179918469378 LMWIPDTK(ub)GVYPDLLATSGDYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LMWIPDTKGVYPDLLATSGDYLR 23 1 P61962 P61962 DCAF7 DDB1- and CUL4-associated factor 7 1 111298000.0 59114000.0 27408000.0 24776000.0 True False 89680259.81228364 22516828.260318574 19879012.74029342 1.0 0.2510789811208198 0.22166542315893875 26.418287121986346 -13.263841951537433 0.4697231962900296 9.998411994187698 0.2223149916515738 0.9999071815721962 0.003470031913759107 19.414321786957174 0.2361513383204616 177.97301845293345 0.006362638725208361 5.447008443270284e-14 13.263841951537433 -9.776097002536124 LMWIPDTK(ub)GVYPDLLATSGDYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMWIPDTKGVYPDLLATSGDYLR 23 1 P61962 P61962 DCAF7 DDB1- and CUL4-associated factor 7 1 36644500.0 23110000.0 10997000.0 2537500.0 True False 19216988.946588617 10937756.97826641 3068079.5179256108 1.0 0.5691712166076919 0.15965453934812476 24.19587896639326 -7.768899573007573 0.38694628916363005 1.054301560609989 1.477292875231423e-23 0.9983295695289848 0.014023065052003333 0.11591906739017079 0.06594939828558254 0.032735540675901155 0.07833741347974263 1.702552163927808e-08 7.768899573007573 -1.054301560609989 down LMWSQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LMWSQR 6 0 P0CB38 P0CB38 PABPC4L Polyadenylate-binding protein 4-like 0 3383300.0 835150.0 941050.0 1607100.0 False True 1081118.1382676563 888679.7402505666 1314624.290238521 1.0 0.8220005832799681 1.2159857870343627 20.044092750287895 -6.7839184450746846 1.520956548030885 0.8997231633007416 1.2194785684467673 0.7808837915455678 0.07540729534308323 0.24454144484542029 1.1176153693794946 0.03904275022945356 0.09181376426908637 1.6446805440984663e-07 6.7839184450746846 0.31975540514602563 LMYQELK(ub)VPAEEPANELPMNEIEAWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LMYQELKVPAEEPANELPMNEIEAWK 26 1 Q8IV08;M0R2E7;M0QY94;M0QX50;M0QX99;A0A0A0MS28;E2QRG1;M0R1F7 Q8IV08 PLD3 Phospholipase D3 1 9487100.0 3597000.0 2442000.0 3448100.0 True False 2991064.874118537 2428844.461300949 4169081.7677869136 1.0 0.8120333605324178 1.3938453170513516 21.51222777117365 -6.8197339784071165 1.3729857989693341 0.89865951160272 1.4064787091410869 0.8837797872994047 0.08264701898110585 0.19382661907438195 0.7180192109367507 0.04730336868065278 0.10903654324875535 1.5144886452423232e-07 6.8197339784071165 0.5078191975383669 LNAFGNAFLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNAFGNAFLNR 11 0 A0A024R571;Q9H4M9;C9JC03;Q9NZN3;C9JIJ3;C9IZH1;Q9NZN3-2 A0A024R571 EHD1;EHD3 EH domain-containing protein 1;EH domain-containing protein 3 0 16715200.0 4933900.0 5027700.0 6753600.0 False True 6468390.679955565 4277586.7578211 6054802.257105692 1.0 0.6613061840987138 0.9360600737782409 22.624975387129705 -9.941500379776944 6.365312439462225 1.000000036829801 0.7986831289384673 0.41719251109520683 0.11216780575999978 5.860365403256699e-08 9.66135410641976e-09 0.10860603034249966 0.03620200364075366 1.144193879254781e-10 9.941500379776944 -0.20131690789133372 LNAFGNAFLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNAFGNAFLNR 11 0 A0A024R571;Q9H4M9;C9JC03;Q9NZN3;C9JIJ3;C9IZH1;Q9NZN3-2 A0A024R571 EHD1;EHD3 EH domain-containing protein 1;EH domain-containing protein 3 0 16111100.0 4933900.0 5883000.0 5294200.0 False True 6758096.163634048 5623069.607520563 4043818.997471584 1.0 0.8320493629224796 0.5983665960883711 22.688185448652597 -6.966476303207211 0.331739566160747 1.0278986763950944 0.3948474169772694 0.9999404212755892 0.001271233999706373 0.0774635004829723 0.013112591641515391 0.003388990183776617 0.020354007168599104 1.0802485618287258e-07 6.966476303207211 -0.633051259417825 LNATNIELATVQPGQNFHMFTK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LNATNIELATVQPGQNFHMFTK 22 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 48210000.0 8397700.0 29724300.0 10088000.0 False True 11009466.023442473 25289550.30441391 9044190.530929008 1.0 2.297073286802905 0.8214922060408015 23.392241161813804 -6.674522634707025 1.9210280839469465 1.8246492663964786 0.8272781839652449 0.2994088334979216 0.5503961355707103 0.45079049209126726 3.211281771544306 0.2302913614727931 0.6117450621949291 2.1158134096867758e-07 6.674522634707025 -0.9973710824312337 LNATNIELATVQPGQNFHMFTK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LNATNIELATVQPGQNFHMFTK 22 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 67882100.0 26137300.0 11881600.0 29863200.0 False True 25307585.718334686 16625984.84172544 22041132.043203503 1.0 0.6569565752643227 0.870929858284952 24.593066548652672 -10.425145254188378 5.79698917775112 1.0001097968155481 0.7639432167746371 0.6187213438252223 0.08735422699811307 0.0001240163361333554 1.2298005521271818e-05 0.0846195252389458 0.028193455532042718 3.75711722680693e-11 10.425145254188378 -0.23616658004091107 LNATNIELATVQPGQNFHMFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LNATNIELATVQPGQNFHMFTK 22 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 55533800.0 8397700.0 20648600.0 26487500.0 False True 11502556.629309392 19736276.57621094 20231698.027186073 1.0 1.7158165103853 1.7588870613020209 23.455451223336695 -11.25260032453511 0.47695512947186897 9.96817261611754e-24 1.7579141369210385 0.9997883259724782 0.005063571617989046 3.4111653272022324 0.2337137113765264 3.6222965581489337 0.009164011107314426 5.589843840315982e-12 11.25260032453511 1.7579141369210385 LNATNIELATVQPGQNFHMFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNATNIELATVQPGQNFHMFTK 22 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 37131000.0 18937000.0 10365000.0 7829000.0 False True 15746954.551343549 10309161.687708579 9466007.70279395 1.0 0.6546765378724605 0.6011325981750737 23.908569503712272 -13.999999999997685 0.26239720016979234 3.5598428752188074 0.5820073655163126 0.9995672628955896 0.003677104786793254 14.5244199111211 0.16210868473324475 19.74329618597557 0.023116800373982373 1.0000000000053295e-14 13.999999999997685 -2.9778355097024947 LNCQVIGASVDSHFCHLAWVNTPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNCQVIGASVDSHFCHLAWVNTPK 24 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 257668900.0 117097900.0 86388200.0 54182800.0 False True 153516480.87767658 73499417.2985661 48576483.61411776 1.0 0.4787721609976922 0.31642520292543685 27.193818304623704 -13.999999999999998 0.16331895518502967 3.585798631651066 0.16253358766926096 0.9995280348086341 0.006335079968681377 12.033456558456095 0.12781456161873883 9.855195835871532 0.14086607616082447 1.0000000000000041e-14 13.999999999999998 -3.423265043981805 LNCQVIGASVDSHFCHLAWVNTPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNCQVIGASVDSHFCHLAWVNTPK 24 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 1331186000.0 264980000.0 627160000.0 439046000.0 False True 401994032.6328604 515238397.9765543 352268365.6593018 1.0 1.2817065830604493 0.8763024748206328 28.58259884469495 -6.719790424635396 1.7597810423715707 1.171419557171788 0.876928276335754 0.5116913428560499 0.11854576407305616 0.3557078591190024 2.1526511362623033 0.05348703436505771 0.13432020754297225 1.9063804487221062e-07 6.719790424635396 -0.29449128083603404 LNCQVIGASVDSHFCHLAWVNTPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNCQVIGASVDSHFCHLAWVNTPK 24 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 496767900.0 117097900.0 151085000.0 228585000.0 False True 160392158.08176148 144409565.1287173 174597930.8558501 1.0 0.9003530275782131 1.08856899828511 27.257028366146596 -6.762867229831147 1.6017255678638433 0.9423265596874695 1.0893548330438307 0.7025591077480946 0.041930668524657926 0.2781192402031988 1.4068990506835293 0.02064907731124129 0.049482564583629214 1.7263655865088822e-07 6.762867229831147 0.14702827335636126 LNCQVIGASVDSHFCHLAWVNTPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNCQVIGASVDSHFCHLAWVNTPK 24 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 296487800.0 102457000.0 3120800.0 190910000.0 False True 85197535.11469625 3103987.6309697 230828398.33189297 1.0 0.036432833729179964 2.7093318840872893 26.34430835605649 -6.809203879696599 1.4179519139155174 0.47436946398502167 2.7552097426320343 0.857713650256959 0.41691871892430105 0.20789372031115552 0.8239810471794832 0.23120970349601766 0.5350125406528154 1.5516584123662618e-07 6.809203879696599 2.2808402786470126 LNCQVIGASVDSHFCHLAWVNTPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNCQVIGASVDSHFCHLAWVNTPK 24 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 865519000.0 264980000.0 344065000.0 256474000.0 False True 343021833.5366859 324917480.2925572 209798363.64547005 1.0 0.9472209886540868 0.6116181045456173 28.3537251667874 -6.934619018295255 0.7078512828447009 1.0043350523621544 0.5338485031993687 0.9973707112895303 0.008819561980159981 0.09030944945502933 0.06644406795832111 0.008268536740693323 0.029633072758785975 1.1624679332974492e-07 6.934619018295255 -0.47048654916278565 LNDHFPLVVWQTGSGTQTNMNVNEVISNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNDHFPLVVWQTGSGTQTNMNVNEVISNR 29 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 7832300.0 3745200.0 1489000.0 2598100.0 False True 3114299.740491728 1480978.4614566395 3141350.6977428743 1.0 0.4755414009130677 1.008686048070272 21.570476374791273 -10.752637589707335 11.544976393438159 1.000359447148345 0.7421137244916698 0.23778421799675797 0.21765539077188809 0.002016345950339326 4.320222571820683e-05 0.2110184103205029 0.07024797530598251 1.7675121599440573e-11 10.752637589707335 -0.2582457226566752 LNDPFQPFPGNDSPK(ub)EKDPEIFCDPFTSATTTTNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNK 35 2 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 32012500.0 14622000.0 13942000.0 3448500.0 True False 19169583.599649407 11861907.945490343 3091682.300347812 1.0 0.6187879816913334 0.1612806185526302 24.192315663437455 -7.545359009083928 0.43031893093383333 1.0302631315358786 1.6517243535393482e-13 0.998313821072705 0.014079621462065178 0.1191927818705591 0.05813597541019369 0.02133202453733312 0.06936081745944343 2.8486624500553433e-08 7.545359009083928 -1.0302631315357134 down LNDPFQPFPGNDSPK(ub)EKDPEIFCDPFTSATTTTNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNK 35 2 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 95997000.0 56367000.0 24613000.0 15017000.0 True False 54577660.43873581 34441099.2550994 11083597.199656693 1.0 0.6310475564221009 0.20307937552761512 25.701807216651073 -7.4866217588011175 0.3877768984132554 1.0417760325889722 1.4162387869404403e-12 0.9990975365139729 0.00978252070194689 0.118864874466929 0.04468399200636656 0.018858738808301086 0.06530059848365662 3.261206064029074e-08 7.4866217588011175 -1.041776032587556 down LNDPFQPFPGNDSPK(ub)EKDPEIFCDPFTSATTTTNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNK 35 2 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 250014200.0 113288200.0 99198000.0 37528000.0 True False 171866481.87681344 81495341.86248846 30110574.350893278 1.0 0.4741782165582516 0.17519747900859023 27.356712970900727 -8.661821045908209 0.27637485599365264 1.2249007230690718 1.8297028499064395e-17 0.9989967108815957 0.010799269157767338 0.24652914491874334 0.08119357346853168 0.15535309012647872 0.10378606519822685 2.178607297864431e-09 8.661821045908209 -1.2249007230690718 LNDPFQPFPGNDSPK(ub)EKDPEIFCDPFTSATTTTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNK 35 2 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 41060000.0 14622000.0 12223000.0 14215000.0 True False 20028148.544692226 11682947.443944205 10857709.76711468 1.0 0.5833263827594473 0.5421224903982522 24.255525724960346 -13.999999999999998 0.3271032564019917 5.457450037669653 0.5345754866608726 0.9997087972920705 0.00352928983884381 18.58176729219484 0.1827390178987103 56.89631922230036 0.013348632488685803 1.0000000000000041e-14 13.999999999999998 -4.92287455100878 LNDPFQPFPGNDSPK(ub)EKDPEIFCDPFTSATTTTNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNK 35 2 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 100455000.0 56367000.0 20937000.0 23151000.0 True False 46871657.98149549 20824208.225330878 27991767.0618703 1.0 0.44428145113945167 0.5972002755464976 25.48221249208535 -10.565369047015661 9.694508175888256 1.000029311434538 0.5207408633430547 0.9290607672307958 0.06242884864392014 3.9552750465810355e-05 1.7732292088870922e-06 0.06045014354464462 0.020148824260067186 2.720388642288931e-11 10.565369047015661 -0.4792884480914833 LNDPFQPFPGNDSPK(ub)EKDPEIFCDPFTSATTTTNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNK 35 2 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 265803100.0 113288200.0 121526900.0 30988000.0 True False 146653808.144278 114763821.18426932 25348501.963730548 1.0 0.7825492064370037 0.17284584890419413 27.127839292993176 -7.084535034412047 0.5808182036486274 1.0044792429235279 1.2921247674054535e-13 0.9990163277299059 0.010980760222118628 0.07586005951602028 0.03986242218655148 0.011525761441336109 0.04539765145163522 8.231234331103496e-08 7.084535034412047 -1.0044792429233986 down LNDYIFSFDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNDYIFSFDK 10 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 6861400.0 1299800.0 1996100.0 3565500.0 False True 1704050.3872811047 1698289.660736858 3196576.262691058 1.0 0.9966193918987112 1.8758695673262051 20.700536564750497 -6.906033617666023 0.922320839636516 0.9692449413822032 1.9803617973431138 0.9893366386070473 0.04271889161337607 0.10710004836424776 0.15342690100895529 0.034302548575322646 0.09228011744136318 1.2415561980657583e-07 6.906033617666023 1.0111168559609105 LNDYIFSFDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNDYIFSFDK 10 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 4026100.0 1299800.0 2726300.0 0.0 False True 1780371.185774242 2605843.051331512 0.0 1.0 1.4636515532002905 0.0 20.763746626273388 -6.844497720665381 1.4188038676384855 1.2478572855933463 2.6937771394191044e-22 0.8870610142806371 0.20525438282947203 0.17991490984657652 0.7274505374446445 0.1161535338707501 0.24708116539661742 1.4305474888313216e-07 6.844497720665381 -1.2478572855933463 down LNEAK(ub)EEFTSGGPLGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNEAKEEFTSGGPLGQK 17 1 P43034;P43034-2 P43034 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit alpha 1 31641300.0 5028700.0 18285000.0 8327600.0 True False 7628905.547214377 15021898.888642928 6681646.20988325 1.0 1.9690765334128475 0.875832866003039 22.863044670307854 -6.67278644100594 1.9271910605076343 1.6170748030125568 0.880170222699275 0.2914789311149034 0.4113816528993063 0.4548137222043498 3.259150231254766 0.17167400659416993 0.4570606114899208 2.1242887982165535e-07 6.67278644100594 -0.7369045803132818 LNEAK(ub)EEFTSGGPLGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNEAKEEFTSGGPLGQK 17 1 P43034;P43034-2 P43034 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit alpha 1 28105500.0 5028700.0 14073000.0 9003800.0 True False 6509751.280496387 13289825.178838786 7365200.7867896175 1.0 2.0415257981754102 1.1314104747528848 22.634170992400303 -6.6135749742583085 2.140534833446703 1.6941718609443839 1.1347567525076168 0.061615741999671014 0.4486293164071079 0.602861618244025 5.239539206363103 0.17276474259615046 0.4977912134448747 2.434585469959319e-07 6.6135749742583085 -0.5594151084367671 LNEFMAGFYIITNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNEFMAGFYIITNK 14 0 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 22173900.0 4426500.0 8129600.0 9617800.0 False True 6715324.120497245 6678809.3631452825 7716837.614368512 1.0 0.9945624728312803 1.1491385189903698 22.67902560348905 -6.898744071350404 0.9691477289692867 0.9933499617919377 1.164957765459282 0.9859318094176487 0.008494877050712023 0.11233653424269446 0.18266810881147855 0.00658909284817267 0.017038657177956943 1.2625713455353841e-07 6.898744071350404 0.1716078036673443 LNEHFLNTTDFLDTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNEHFLNTTDFLDTIK 16 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 12619900.0 4982800.0 0.0 7637100.0 False True 4824623.741446825 0.0 5636714.4019110305 1.0 0.0 1.1683220711053155 22.20198500444791 -10.763599493887103 6.167996409236384 1.014481305240498 0.5841610355526577 0.14450458350466566 0.47696548823994483 0.09430094914522838 0.0036142644194486692 0.4585092407131177 0.15393994938908298 1.7234572135698987e-11 10.763599493887103 -0.4303202696878402 LNEPIK(ub)VLCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNEPIKVLCR 10 1 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 14749800.0 1534700.0 6238200.0 6976900.0 True False 2012006.5620559428 5307484.8763131425 6254997.315150534 1.0 2.637906345041816 3.108835444730829 20.94020357975098 -9.892946448305482 0.31594443884363443 1.6320053726096505e-11 3.2535231549966928 0.9988042944825483 0.031252494965529884 1.2730573311831945 0.13867075593901643 1.3535699108548762 0.15681541268990754 1.2795390709813758e-10 9.892946448305482 3.253523154980373 LNEPIK(ub)VLCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNEPIKVLCR 10 1 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 5895480.0 253080.0 2695900.0 2946500.0 True False 245046.11392898782 3772386.9289327804 2174723.2568947463 1.0 15.39460009566193 8.874751050020576 17.902693742344113 -9.407730219172626 9.645186649129235 1.000000555992142 12.134675572841287 0.795452018761534 2.6617172269656715 0.0 1.7990998584812083e-16 2.5771968151038154 0.8590655410292648 3.9108375896740434e-10 9.407730219172626 11.134675016849144 LNEPIK(ub)VLCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNEPIKVLCR 10 1 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 86308100.0 3048100.0 19234000.0 64026000.0 True False 4624190.545959025 15801542.424072096 51371233.03640726 1.0 3.4171477725719384 11.109237935988476 22.140769416567235 -6.950117361748308 0.5575534311419699 0.8980798989387438 13.994382766617418 0.9992104632981611 0.1211135803731319 0.08343864169202887 0.03576755794909063 0.13021386082047517 0.6390866504782293 1.1217152861477642e-07 6.950117361748308 13.096302867678675 LNEPIK(ub)VLCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNEPIKVLCR 10 1 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 15991100.0 1534700.0 3368400.0 11088000.0 True False 2102120.063708057 3219572.950190761 8469242.764528131 1.0 1.5315837595458563 4.028905346913782 21.00341364127387 -6.941204545040643 0.6482598382308298 0.9724471827844018 4.726909622831117 0.9983174637977916 0.054165201032974536 0.08722136676707237 0.05213910727506329 0.05322004470912786 0.21382448645578975 1.1449735520867329e-07 6.941204545040643 3.7544624400467157 up LNEPIK(ub)VLCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNEPIKVLCR 10 1 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 48624100.0 3048100.0 15667000.0 29909000.0 True False 3945825.537033635 14795117.677600171 24465868.8922556 1.0 3.749562046963369 6.200443649277099 21.911895738659684 -7.438800599126731 0.24961179320244953 3.5599734064535365e-16 8.87151240494579 0.9998850974533497 0.022770271766737404 0.1294489771302686 0.02323327532606985 0.19249430123732725 0.5005789602045918 3.640821615230475e-08 7.438800599126731 8.87151240494579 LNEQASEEILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNEQASEEILK 11 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 0 93383700.0 6570700.0 35241000.0 51572000.0 False True 8614251.33074931 29983180.168342084 46235824.15355579 1.0 3.4806484065904306 5.367364194322151 23.038293985815027 -7.864226575027751 0.24906371839219918 2.8432368969916393e-22 7.160651621693639 0.9996645104051239 0.03275803558401508 0.12154454411122868 0.04158055842466243 0.35025419434042093 0.5746047866713504 1.3670154562424322e-08 7.864226575027751 7.160651621693639 LNEQASEEILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNEQASEEILK 11 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 0 89644000.0 29842000.0 6514000.0 53288000.0 False True 28894682.04468496 9115074.170061236 39330274.19426681 1.0 0.31545853856308176 1.3611596117736628 24.78430065888435 -6.730101092899842 1.7229743522951135 0.5880872146688667 1.3605344832136912 0.5596714813512692 0.2877627477366929 0.3360556652823606 1.9545162270866898 0.13235349328672721 0.3283744867069954 1.8616537397657798e-07 6.730101092899842 0.7724472685448245 LNEQASEEILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNEQASEEILK 11 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 0 88918700.0 6570700.0 38802000.0 43546000.0 False True 9000065.356490854 37087599.33894485 33261331.658021484 1.0 4.120814446330353 3.6956766801735927 23.10150404733792 -9.711838268441474 6.598760015749873 0.9999999908090409 3.908245563253645 0.9842255894297424 0.17356176625112857 2.320603169145575e-08 4.553850041893764e-09 0.16805045755457754 0.05601681918486027 1.9416087994050384e-10 9.711838268441474 2.908245572444604 LNEQASEEILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNEQASEEILK 11 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 0 38168100.0 29842000.0 5588800.0 2737300.0 False True 24814945.224755462 5558692.025110056 3309656.7741547897 1.0 0.22400581483309856 0.13337352729084676 24.564705934318628 -13.999999999999998 0.30301791811841833 8.202572293410496 0.11176296401503574 0.9996565535152042 0.007207831518196512 16.78769386815305 0.1749121649769108 75.94037129934227 0.032334607406775434 1.0000000000000041e-14 13.999999999999998 -8.09080932939546 LNEQASEEILK(ub)VEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNEQASEEILKVEQK 15 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 35242400.0 15623000.0 11263000.0 8356400.0 True False 20481904.293347217 9582604.302830147 7491759.888248935 1.0 0.4678570979331594 0.3657745774489511 24.287846519532334 -13.999999999999998 0.23216202052010929 4.393221735645075 0.31715128572516227 0.9995128214729373 0.006137294189951791 13.359600223721817 0.15254759079225574 20.921997291391637 0.05228655745567499 1.0000000000000041e-14 13.999999999999998 -4.0760704499199125 LNEQASEEILK(ub)VEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNEQASEEILKVEQK 15 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 57518000.0 25199000.0 19211000.0 13108000.0 True False 24399071.53823523 26882052.484041523 9674621.56842909 1.0 1.1017653865195352 0.3965159720634538 24.540322913939484 -6.870278789418004 1.1325673416385502 1.0576578391962523 0.35498430909120104 0.9649633156954396 0.05826128149401442 0.13659058338592486 0.32728285587462413 0.039914814770767235 0.09454971590079804 1.348097212154144e-07 6.870278789418004 -0.7026735301050513 down LNEQASEEILK(ub)VEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNEQASEEILKVEQK 15 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 64085000.0 19396000.0 25888000.0 18801000.0 True False 29425150.037538562 21268084.13613279 15084974.109228976 1.0 0.7227859198338988 0.5126558094006186 24.810546435732213 -7.302928745125016 0.141816242371495 1.2989468557199106 3.784048281291613e-09 0.9999951673338743 0.000438715681126182 0.10862999224203337 0.00832689925191888 0.02514616287115022 0.04739751417921924 4.9781875560768784e-08 7.302928745125016 -1.2989468519358625 LNEQASEEILK(ub)VEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNEQASEEILKVEQK 15 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 43844000.0 15623000.0 15781000.0 12440000.0 True False 21399245.295700107 15083743.239211624 9501928.209842177 1.0 0.7048726733480878 0.44403099635254256 24.351056581055225 -7.084541583643226 0.19600438161496256 1.1707856218237498 1.4888808475021e-14 0.9999945157939204 0.000531840422962679 0.07496010746466542 0.006859009813369027 0.010013729545293736 0.029026626264654937 8.231110203691576e-08 7.084541583643226 -1.170785621823735 down LNEQASEEILK(ub)VEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNEQASEEILKVEQK 15 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 53809500.0 25199000.0 21465000.0 7145500.0 True False 20954085.00497997 21349363.784531068 8639591.012940865 1.0 1.0188640439063388 0.4123105833963912 24.32072818937376 -6.899720819947141 0.9630188849265053 1.0254118144887348 0.34899960310631045 0.9864272589389826 0.03280595323085846 0.11161148945324194 0.1785757965207778 0.025562589635436277 0.06641772451934126 1.2597349543272114e-07 6.899720819947141 -0.6764122113824242 down LNEQASEEILK(ub)VEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNEQASEEILKVEQK 15 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 83211000.0 19396000.0 37665000.0 26150000.0 True False 25108504.35231929 35568909.63980405 21390968.321658473 1.0 1.4166080599905795 0.8519411599155079 24.581672757824663 -6.709048665705061 1.7987177498668234 1.2563711494054248 0.8533113122546694 0.4605368946811875 0.17558263505346655 0.37698565757409047 2.3770187123434683 0.07770112349116765 0.19761642821055284 1.9541204707712618e-07 6.709048665705061 -0.40305983715075544 LNESK(ub)LVQEALEAVPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNESKLVQEALEAVPR 16 1 Q15269;A0A0B4J2E5 Q15269 PWP2 Periodic tryptophan protein 2 homolog 1 5825100.0 1332000.0 2009900.0 2483200.0 True False 1289716.3890999383 2812463.551490036 1832775.4255968235 1.0 2.180683734237715 1.4210685706458865 20.298622418675254 -10.174187664278929 5.744940958456454 0.9999941056795313 1.8008761521084842 0.597117950243811 0.3101115919860698 5.732323402346693e-05 8.240232831747979e-06 0.3002696561345328 0.10008808592974448 6.695952061195871e-11 10.174187664278929 0.8008820464289529 LNESK(ub)LVQEALEAVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNESKLVQEALEAVPR 16 1 Q15269;A0A0B4J2E5 Q15269 PWP2 Periodic tryptophan protein 2 homolog 1 2884680.0 521180.0 0.0 2363500.0 True False 713874.3303599167 0.0 1805289.9778104492 1.0 0.0 2.5288624356338314 19.445310600618654 -6.799433342914146 1.458323047546644 0.44785514078216276 2.5632435027543927 0.8304658683719213 0.4281746854579488 0.22157346132780395 0.9303812813558775 0.23099070226927956 0.5373622739306884 1.5869624729931498e-07 6.799433342914146 2.11538836197223 LNESK(ub)LVQEALEAVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNESKLVQEALEAVPR 16 1 Q15269;A0A0B4J2E5 Q15269 PWP2 Periodic tryptophan protein 2 homolog 1 5259800.0 1332000.0 2348500.0 1579300.0 True False 1107617.0176051962 2335848.16435925 1909524.328141839 1.0 2.1088951571091243 1.723993309772781 20.07902769410953 -10.146962551448837 4.678651306223431 0.9999065939924356 1.916444233432641 0.8831607099477036 0.15713552120520988 0.0001533492729604668 2.795877080329193e-05 0.15216118612926374 0.05071527138900629 7.129145010069105e-11 10.146962551448837 0.9165376394402054 LNESTFDTQITK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNESTFDTQITKK 13 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 18771400.0 4998500.0 7294300.0 6478600.0 True False 6553081.905542851 6206018.872958709 5808256.619119422 1.0 0.9470381970518965 0.8863396952518742 22.643742133095877 -6.969344479826875 0.27340775356996 1.014479305993741 0.8170654920640065 0.9999767859631749 0.00022366550069066266 0.07651613388623264 0.009789818987968664 0.0011655013777664444 0.005619261522703913 1.0731378680252798e-07 6.969344479826875 -0.19741381392973445 LNESTFDTQITK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNESTFDTQITKK 13 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 14035200.0 3262400.0 2679300.0 8093500.0 True False 3158836.8977474747 3749158.462364916 5973569.550204526 1.0 1.1868794064797685 1.891066156174192 21.590962016733226 -6.946248734557121 0.5986232111704042 0.9920437836738926 2.1218635598710702 0.9988729589006824 0.012880242239184487 0.08502815946329355 0.04247426197492524 0.013237550527200782 0.059151502266595865 1.1317519864543332e-07 6.946248734557121 1.1298197761971775 LNESTFDTQITK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNESTFDTQITKK 13 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 51809700.0 8486400.0 9354300.0 33969000.0 True False 12874489.238944478 7684952.079520515 27255012.260858368 1.0 0.5969131619042443 2.116978138318199 23.618011862561108 -6.8361812838634135 1.2999448054620808 0.7853430323818247 2.1633290210576037 0.9176895017750692 0.18446741491331906 0.17331413793895847 0.5705455804062255 0.11133342191834719 0.25629697615356595 1.4582054468819903e-07 6.8361812838634135 1.377985988675779 up LNESTFDTQITK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNESTFDTQITKK 13 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 19861900.0 4998500.0 5603700.0 9259700.0 True False 6846580.529383402 5356110.005042147 7072749.569507682 1.0 0.7823043900609045 1.033033868389283 22.70695219461877 -6.677134556674231 1.91210422728202 0.861909259007285 1.0320588497220322 0.3110646100577812 0.09232280289451267 0.4449075909505237 3.142426038596128 0.038779085905839956 0.1026528879068592 2.1031267308597045e-07 6.677134556674231 0.17014959071474722 LNESTFDTQITK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNESTFDTQITKK 13 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 18608200.0 3262400.0 5986600.0 9359200.0 True False 2712830.148825218 5954348.997552938 11316165.447948536 1.0 2.194884556311588 4.17135051851623 21.371367292167502 -6.963581583450883 0.3816209395209605 0.8666859655807356 5.569621335700637 0.9998808436453102 0.014275115615312781 0.07844572981917645 0.016578336857134376 0.025680496360397813 0.16688091708848846 1.087472833584193e-07 6.963581583450883 4.702935370119901 LNESTFDTQITK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNESTFDTQITKK 13 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 40039100.0 8486400.0 7972700.0 23580000.0 True False 10985812.091953097 7529012.236433448 19288681.951231636 1.0 0.6853396156255313 1.7557811648134996 23.389138184653557 -6.827995836604231 1.3368596615945925 0.8316202702134884 1.7834210991884072 0.9018045783187836 0.14076336262440237 0.183296250155846 0.6413780492659931 0.08268987352845172 0.1903131115125831 1.4859498873858467e-07 6.827995836604231 0.9518008289749188 LNESVMVFTK(ub)DQTEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNESVMVFTKDQTEK 15 1 Q9NS91 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 13751900.0 4782200.0 6387200.0 2582500.0 True False 4630391.67864393 8937642.268807968 1906065.7766606759 1.0 1.9302130120071121 0.4116424503464234 22.14270280361685 -6.740943456623406 1.68323121701849 1.5528659642328273 0.4105654482192107 0.6091785365041164 0.39082836525458675 0.3161103978169477 1.758922450410609 0.18365765252704983 0.45021536441400406 1.8157520509223219e-07 6.740943456623406 -1.1423005160136166 LNESVMVFTK(ub)DQTEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNESVMVFTKDQTEK 15 1 Q9NS91 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 11720000.0 4782200.0 4506400.0 2431400.0 True False 3976611.187381051 4482123.128749636 2939794.4984765826 1.0 1.127121289346246 0.7392712940619917 21.923108079051126 -6.8184095547266175 1.3786959385932114 1.068630517511172 0.7310865537477398 0.8806928380465582 0.0557629016075688 0.1955587924013571 0.7308266693062572 0.03178667832105475 0.07329770638461115 1.5191142766982558e-07 6.8184095547266175 -0.3375439637634323 LNESVMVFTK(ub)DQTEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNESVMVFTKDQTEK 15 1 Q9NS91 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 29375800.0 5120800.0 10369000.0 13886000.0 True False 6628976.546058804 9791956.03491645 11358890.482391953 1.0 1.4771444682117885 1.713520994299682 22.660354717806644 -10.728860228139682 0.13734360877631197 5.764001258617355e-16 2.0911988924158034 0.9997376086731322 0.004807227777866241 2.746132094738179 0.07679357425178783 1.143230986031612 0.24824126030187446 1.8669804568014398e-11 10.728860228139682 2.091198892415803 LNFAVASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNFAVASR 8 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 311784000.0 86868000.0 87176000.0 137740000.0 False True 113884789.23090857 74169680.60938643 123487986.09537685 1.0 0.6512694198257042 1.084323788359455 26.762999828651022 -6.692402566347131 1.858094018882069 0.781855831831143 1.0828617481742877 0.3815540861694928 0.1474183240039444 0.41154852888647997 2.756716245181314 0.06342897953278541 0.1646619237288177 2.0304740041380768e-07 6.692402566347131 0.30100591634314466 LNFAVASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNFAVASR 8 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 170428000.0 68166000.0 16735000.0 85527000.0 False True 66002107.64218201 23417372.771872107 63124912.9449982 1.0 0.35479734827295184 0.9564075330323998 25.976008758930725 -10.766621225785027 10.045575729851755 1.0015582456204328 0.6556024406526798 0.3040799843873442 0.2456063294536934 0.008599027339192546 0.0001997721206931014 0.2385734404536464 0.07926910197477385 1.7115073723714736e-11 10.766621225785027 -0.345955804967753 LNFAVASR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNFAVASR 8 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 123187000.0 37139000.0 52405000.0 33643000.0 False True 56342578.22458989 43052918.3078662 26993446.303749286 1.0 0.7641275863566426 0.47909497851073474 25.747722246858086 -6.96860002458179 0.2896781020306301 1.0559083024440437 0.17851186468944436 0.9999693102636934 0.0011798261586065295 0.07675961538376148 0.010647803879331421 0.00498829558804965 0.02585767417469687 1.0749789879744812e-07 6.96860002458179 -0.8773964377545993 down LNFAVASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNFAVASR 8 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 217448000.0 86868000.0 48990000.0 81590000.0 False True 118985447.11943132 46825459.81173424 62320122.39879609 1.0 0.39353938607915057 0.5237625601073923 26.826209890173914 -9.87337968419171 6.731504757994939 1.0000000141132623 0.4586509730939865 0.9584058221943408 0.05316338817586198 1.1225880711675867e-08 1.937114014088712e-09 0.0514752300252826 0.01715840975274814 1.3385059799924616e-10 9.87337968419171 -0.5413490410192758 LNFAVASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNFAVASR 8 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 133710000.0 68166000.0 37800000.0 27744000.0 False True 56683049.2658227 37596363.89728745 33545142.126237698 1.0 0.6632734897689484 0.5918020036099909 25.756414034365 -13.999999999999998 0.21784506952181387 3.012968183703364 0.5527733132996662 0.9994958269007054 0.003996509424048873 12.941860764750276 0.1478765503282814 11.194395048502608 0.04012381418045332 1.0000000000000041e-14 13.999999999999998 -2.460194870403698 LNFGLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNFGLAR 7 0 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 14530600.0 3527300.0 2927200.0 8076100.0 False True 4624324.458421792 2490473.170136231 7240462.643421478 1.0 0.5385593490527241 1.5657341323088154 22.140811195132954 -6.784534788003 1.5177852711542354 0.7402672864054846 1.575125176844491 0.7832724269346231 0.1955558149071312 0.24357186530820843 1.1084468525513753 0.10144356529305286 0.23851540054709985 1.6423480984844745e-07 6.784534788003 0.8348578904390064 LNFGLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNFGLAR 7 0 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 7437300.0 2232900.0 1614900.0 3589500.0 False True 2162017.811727667 2259737.991592248 2649302.2673082254 1.0 1.0451986007397842 1.225384107816933 21.043946978051373 -6.944952445366118 0.6117597165567897 0.9980117345080671 1.2819828032231169 0.9987432189973814 0.0034514542901248955 0.08557821027644193 0.044854978910103295 0.0035025051656733643 0.01520315394744008 1.1351351045620962e-07 6.944952445366118 0.28397106871504973 LNFGLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNFGLAR 7 0 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 12952100.0 3527300.0 3566400.0 5858400.0 False True 4831438.13169833 3408824.65549232 4474766.577535327 1.0 0.7055507206286138 0.9261769385345254 22.204021256655846 -10.457520157397724 5.318157052684916 1.000239964007249 0.8158638295815678 0.481531719084313 0.0900702762916026 0.0002565975037073124 2.617406397751038e-05 0.0873230681449486 0.029070056672138873 3.4872239811513364e-11 10.457520157397724 -0.18437613442568124 LNFGLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNFGLAR 7 0 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 5614000.0 2232900.0 1792600.0 1588500.0 False True 1856755.2842422244 1782942.9079967572 1920648.0056058445 1.0 0.9602465780644909 1.0344109543707025 20.82435225348565 -6.761122462832873 1.6084696481867435 0.9769411782231541 1.034694990288604 0.6954630363242329 0.016723030750484764 0.28102780596135873 1.4332662970458168 0.008202609679184084 0.019688611091046634 1.7333151667308697e-07 6.761122462832873 0.05775381206544994 LNFHLYMALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNFHLYMALK 10 0 Q13895;H7BY94 Q13895 BYSL Bystin 0 82196200.0 16551200.0 26052000.0 39593000.0 False True 25109380.454800375 21402817.05479495 31767426.195771623 1.0 0.8523833191871203 1.2651616893915985 24.58172309641259 -6.810015845654305 1.4145641474323472 0.9195509018942307 1.2723784493199477 0.8598333389937818 0.06393745259422129 0.20678761149780175 0.8155387852768935 0.035541106169181026 0.08220955444943634 1.548760109870729e-07 6.810015845654305 0.352827547425717 LNFHLYMALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNFHLYMALK 10 0 Q13895;H7BY94 Q13895 BYSL Bystin 0 39795200.0 16551200.0 11248000.0 11996000.0 False True 21425854.67292776 10622038.912213359 9812851.08935432 1.0 0.49575800239299855 0.4579911158341406 24.352849418505038 -13.999999999999993 0.3676698402472818 7.921671626845653 0.4539317469333321 0.9997868854760045 0.003607054784664584 22.549760870775273 0.1966069497284219 122.89290732338755 0.010632600101773994 1.0000000000000164e-14 13.999999999999993 -7.467739879912321 LNFLTK(ub)IHEMLQPGQDQ ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNFLTKIHEMLQPGQDQ 17 1 J3KQL8;Q9BQE5 J3KQL8 APOL2 Apolipoprotein L2 1 30405800.0 10308000.0 9870800.0 10227000.0 True False 15637989.6157428 8109278.6190875955 8205628.967346667 1.0 0.5185627320614131 0.5247240322429964 23.898551719195503 -9.80056789557665 6.353150615213489 1.0000000114704068 0.5216433821523767 0.999875591320097 0.0025153402668762793 4.073277186733892e-10 7.997263461159619e-11 0.002435467813183003 0.0008118225802001595 1.5828220963279373e-10 9.80056789557665 -0.47835662931803014 LNFLTK(ub)IHEMLQPGQDQ ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNFLTKIHEMLQPGQDQ 17 1 J3KQL8;Q9BQE5 J3KQL8 APOL2 Apolipoprotein L2 1 18263400.0 9483500.0 7644400.0 1135500.0 True False 7885950.440284441 7603218.099905398 1372927.8000411943 1.0 0.9641473348685101 0.1740979493134722 22.91085321309725 -6.916391112107996 0.8510661165022931 1.0198006840367495 0.0567032935346977 0.9931181975351531 0.03162012500060126 0.10034210961564594 0.11696265885728307 0.026735546176119025 0.07751924671862473 1.2122966020873263e-07 6.916391112107996 -0.9630973905020518 down LNFLTK(ub)IHEMLQPGQDQ ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNFLTKIHEMLQPGQDQ 17 1 J3KQL8;Q9BQE5 J3KQL8 APOL2 Apolipoprotein L2 1 29610200.0 10308000.0 7162200.0 12140000.0 True False 13343909.201057287 6763617.273920199 9930644.566919073 1.0 0.5068692518819218 0.7442080440814325 23.669678041287952 -10.540611378965924 6.8206520935476185 1.0002754717330158 0.6255386479816771 0.7684682117519959 0.09689315617620828 0.0004061712202710425 2.7356593398267623e-05 0.09388364879903775 0.03127213168599407 2.879974358138696e-11 10.540611378965924 -0.37473682375133865 LNFSHGTHEYHAETIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNFSHGTHEYHAETIK 16 0 P14618;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 234361700.0 40708000.0 88473600.0 105180100.0 False True 53368582.216832824 75273683.7473917 94297072.21076187 1.0 1.4104493809027936 1.766902328932769 25.66948734958848 -6.972775486444959 0.17993609770224644 0.7242095145674893 2.4627807153212546 0.9999967209144056 0.0005673836988586681 0.07541192592240478 0.005674173055420122 0.01373429721151125 0.04000960293010595 1.0646932814846368e-07 6.972775486444959 1.7385712007537655 LNFSHGTHEYHAETIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNFSHGTHEYHAETIK 16 0 P14618;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 203081700.0 36757000.0 21785000.0 144539700.0 False True 35590169.15476456 30483864.107274186 106680416.47194615 1.0 0.8565248446759129 2.9974686551233916 25.084975453989834 -6.8908694136057305 1.0172419450229186 0.8873463545658058 3.1847647847481584 0.9814477766213349 0.13309970536825746 0.11844111208836884 0.21776025266248578 0.09958157476332102 0.24904430690502774 1.285673186122936e-07 6.8908694136057305 2.2974184301823524 up LNFSHGTHEYHAETIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNFSHGTHEYHAETIK 16 0 P14618;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 438616000.0 19332000.0 405168000.0 14116000.0 False True 29328057.358511865 332862604.807967 11325966.412737403 1.0 11.349630176284434 0.386181951101861 24.80577817676361 -6.6591797134322235 1.9758520591707252 7.666375936828482 0.4319885606373919 0.2321370043776967 4.407491287836705 0.48637059930359244 3.64929241774823 1.8027755364031242 4.885343832122344 2.191897728389998e-07 6.6591797134322235 -7.23438737619109 LNFSHGTHEYHAETIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNFSHGTHEYHAETIK 16 0 P14618;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 230581800.0 40708000.0 91424800.0 98449000.0 False True 55758847.6923357 87385350.03461596 75197373.82079995 1.0 1.5672015052532633 1.3486177877226138 25.73269741111137 -10.110550526838157 4.598956766269394 0.9999628260182329 1.4579096464987082 0.854045265970357 0.08923642904188643 62181153.35332087 1.5456965089296466 24477.902547406673 0.03054800320540758 7.752637421113506e-11 10.110550526838157 0.4579468204804753 LNFSHGTHEYHAETIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNFSHGTHEYHAETIK 16 0 P14618;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 84197000.0 36757000.0 30751000.0 16689000.0 False True 30565074.11119682 30585338.259404402 20178592.7387825 1.0 1.000662983774679 0.66018464949151 24.86538072942411 -6.906459407898986 0.9195185670823761 1.011758247528727 0.6193610876137466 0.9895152068342505 0.016418773538563497 0.10680582903019825 0.15181588967264517 0.013211251845211732 0.03563309731614382 1.240339550228587e-07 6.906459407898986 -0.39239715991498036 LNFSHGTHEYHAETIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNFSHGTHEYHAETIK 16 0 P14618;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 83405000.0 19332000.0 36312000.0 27761000.0 False True 25025655.090690713 34291205.2791866 22708782.851914383 1.0 1.3702420637908725 0.9074201162614847 24.57690449885606 -6.693663920812904 1.8532658422959192 1.231315837375532 0.9089400282847059 0.38766665283457025 0.15647180587431625 0.40885195375210764 2.7252991993313427 0.06747055555156901 0.17489938551500703 2.0245852998375586e-07 6.693663920812904 -0.3223758090908261 LNFSHGTHEYHAETIK(ub)NVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNFSHGTHEYHAETIKNVR 19 1 P14618;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 32664700.0 4751400.0 7470300.0 20443000.0 True False 4600569.407784863 10453229.74709987 15088365.02314586 1.0 2.2721599916330826 3.2796733807806597 22.133381002439126 -7.331257781626227 0.17022300540657484 2.0819176056279587e-19 5.218595299190513 0.9999879079144074 0.003243547194155716 0.11531334906460154 0.011250024508845324 0.10349589153946724 0.21663894419473242 4.6638247023537556e-08 7.331257781626227 5.218595299190513 LNFSHGTHEYHAETIK(ub)NVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNFSHGTHEYHAETIKNVR 19 1 P14618;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 99682000.0 24566000.0 15325000.0 59791000.0 True False 37268418.01516661 12590134.015228476 47973282.6426738 1.0 0.33782314049672957 1.2872368937997523 25.15145024447729 -6.719196751900611 1.7624920361287741 0.5967896793931641 1.2856622908378592 0.508613897055135 0.27867398402603877 0.35687060318001657 2.1661429260582117 0.1255736860907578 0.31550101770977507 1.9089882184411707e-07 6.719196751900611 0.6888726114446951 LNFSHGTHEYHAETIK(ub)NVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNFSHGTHEYHAETIKNVR 19 1 P14618;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 14122800.0 3786700.0 5377700.0 4958400.0 True False 5186745.321719744 5140095.43232421 3787328.04145349 1.0 0.9910059417800628 0.7301935619614621 22.30639810191113 -6.914219183892356 0.8665013808070683 1.0070380870566267 0.6932584793949833 0.9924189057472347 0.010894300887714406 0.10169382422884646 0.12411973028843162 0.009109724879487269 0.025946833851656307 1.21837454281594e-07 6.914219183892356 -0.31377960766164337 LNFSHGTHEYHAETIK(ub)NVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNFSHGTHEYHAETIKNVR 19 1 P14618;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 83816000.0 24566000.0 16232000.0 43018000.0 True False 31801171.268255055 15328674.930925228 35189165.40195432 1.0 0.48201604908265755 1.1065367720301948 24.922576566569738 -6.686479812580694 1.8787063050378592 0.6741961367768243 1.1043042874860522 0.3540937836393 0.21922915308285856 0.42428249188453504 2.900536278525058 0.09344404423299649 0.24443963457299953 2.0583545673298616e-07 6.686479812580694 0.4301081507092279 LNFSTPTSTNIVSVCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNFSTPTSTNIVSVCR 16 0 O15067;J3QSG0;J3QSH6 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 21701000.0 5692400.0 7102200.0 8906400.0 False True 7462791.525280013 6042579.444158772 7984851.164221461 1.0 0.8096942576634616 1.069955007743816 22.831283954007933 -6.710677290878617 1.7926740628098612 0.8830856574348509 1.0693587730899052 0.4683551927786327 0.08018535291818138 0.3737246257697337 2.3415983321932905 0.03558878133693778 0.09034199547733285 1.9468061482190103e-07 6.710677290878617 0.18627311565505433 LNFSTPTSTNIVSVCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNFSTPTSTNIVSVCR 16 0 O15067;J3QSG0;J3QSH6 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 19646400.0 5692400.0 5101100.0 8852900.0 False True 7797034.111325816 4875716.5349180885 6762027.351198698 1.0 0.6253296401301772 0.8672563508958249 22.894494015530825 -10.114412422155587 4.984312983019647 1.000009778827739 0.7462929955121369 0.5945416352095066 0.09876616609061598 1.0732953038944798e-05 1.9070757808692374e-06 0.09563361444673134 0.03187664303604766 7.684003921752775e-11 10.114412422155587 -0.253716783315602 LNGFQLENFTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNGFQLENFTLK 12 0 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 0 9135800.0 2856600.0 3531900.0 2747300.0 False True 3745030.263353748 3004954.2872383674 2463035.7499624593 1.0 0.8023845138563372 0.6576811338653276 21.83654594638309 -6.974527671972601 0.10327410817383957 1.3388062471293827 0.11758190491648138 0.9999997064918056 7.579341279985807e-05 0.07485917995659581 0.003038148055746643 0.012510337728952386 0.02317265188556087 1.0604063702311108e-07 6.974527671972601 -1.2212243422129012 LNGFQLENFTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNGFQLENFTLK 12 0 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 0 8263600.0 3128500.0 0.0 5135100.0 False True 3029187.479954322 0.0 3790063.2603021213 1.0 0.0 1.2511814753569737 21.53049944030333 -6.6938220103107735 1.8525778407076428 0.3753362315210689 1.2471002622225698 0.38849962900416246 0.4226053581681733 0.4084984119678514 2.7210084872394042 0.182281882653017 0.4724455651085748 2.0238484555082589e-07 6.6938220103107735 0.8717640307015009 LNGFQLENFTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNGFQLENFTLK 12 0 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 0 12029700.0 2856600.0 3380500.0 5792600.0 False True 3912762.216712339 3231138.3321814137 4424507.182341787 1.0 0.8257947079892698 1.1307886698158307 21.89975600790598 -6.751781700636454 1.643135863822473 0.8977839097700019 1.1314817633187548 0.6566115711642044 0.0732099793116922 0.2969666330773384 1.5780097676854512 0.03518764568127182 0.08527075413902539 1.770998932303628e-07 6.751781700636454 0.23369785354875294 LNGFQLENFTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNGFQLENFTLK 12 0 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 0 6822000.0 3128500.0 1596400.0 2097100.0 False True 2601486.3660494415 1587799.8763394102 2535593.914105144 1.0 0.610343339508101 0.9746712291848908 21.310904715737607 -10.520895817969757 8.96396089526363 1.0000105276564544 0.7925072853934289 0.3019068590668821 0.1487362381288563 3.1294873890947415e-05 1.6726120584373409e-06 0.1440205438167953 0.048004414437550096 3.0137288948450315e-11 10.520895817969757 -0.20750324226302552 LNGGLGTSMGCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNGGLGTSMGCK 12 0 A0A087WYS1;E7EUC7;Q16851-2;Q16851;C9JVG3;C9JQU9;C9JNZ1;C9JWG0;C9JUW1 A0A087WYS1 UGP2 UTP--glucose-1-phosphate uridylyltransferase 0 4773600.0 1195800.0 1694500.0 1883300.0 False True 1567705.3801436743 1441687.2051092684 1688434.1818892334 1.0 0.9196161621752827 1.077009879072109 20.580223027665813 -6.767890260860543 1.5826964501380454 0.9537694870658778 1.0778219494780645 0.7223649223713485 0.033859628461837675 0.2698548624697911 1.3337458125252784 0.016866840247590786 0.040225576119309506 1.706513542695457e-07 6.767890260860543 0.1240524624121867 LNGGLGTSMGCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNGGLGTSMGCK 12 0 A0A087WYS1;E7EUC7;Q16851-2;Q16851;C9JVG3;C9JQU9;C9JNZ1;C9JWG0;C9JUW1 A0A087WYS1 UGP2 UTP--glucose-1-phosphate uridylyltransferase 0 4530300.0 1195800.0 1144500.0 2190000.0 False True 1637919.5752799215 1093932.2056446169 1672767.1044657866 1.0 0.6678790718144162 1.0212754824545702 20.643433089188704 -11.042342461548097 12.70434132396021 1.5363491505517677 0.8445772771344932 0.205021301337043 0.1442734804999082 0.04076431635359944 0.0001358640912270098 0.002598156438301405 0.04656406560629375 9.071049533237082e-12 11.042342461548097 -0.6917718734172745 LNGSAAGHVLVK(ub)DNGLGCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNGSAAGHVLVKDNGLGCK 19 1 Q5VWP2 Q5VWP2 FAM46C Protein FAM46C 1 25289700.0 1486900.0 8306800.0 15496000.0 True False 2255736.006950714 6824386.638675364 12433208.807861932 1.0 3.025348098202553 5.511819100085671 21.10516680561202 -6.9683724297734 0.29447802364880227 0.5394613240546555 8.075011121033116 0.9999667581017796 0.010638334843166059 0.07683442428145328 0.010910511961741271 0.042424136931908864 0.22434151830635587 1.075542485246297e-07 6.9683724297734 7.535549796978461 LNGSAAGHVLVK(ub)DNGLGCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNGSAAGHVLVKDNGLGCK 19 1 Q5VWP2 Q5VWP2 FAM46C Protein FAM46C 1 24357700.0 1486900.0 6135800.0 16735000.0 True False 1924821.3611808375 5794337.336198323 13689401.715600565 1.0 3.0103247257416235 7.112037507315694 20.876293127704468 -6.959652525885868 0.4403036500502464 0.8538036678675961 9.42855900633163 0.9997570940203601 0.0396408632428455 0.07982547923124446 0.02159172475220989 0.054099085660820695 0.3398330423299445 1.097355827019065e-07 6.959652525885868 8.574755338464033 LNGTDPEDVIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNGTDPEDVIR 11 0 J3QRS3;P19105;O14950;P24844;J3KTJ1 J3QRS3 MYL12A;MYL12B;MYL9 Myosin regulatory light chain 12A;Myosin regulatory light chain 12B;Myosin regulatory light polypeptide 9 0 12303550.0 5059700.0 760350.0 6483500.0 False True 4899082.59303976 1063961.7201728674 4785276.849169212 1.0 0.2171757058524513 0.9767699887255964 22.22408018337083 -10.87344688596625 11.481635503785423 1.014200301950401 0.5969728472890239 0.27291580120966474 0.31010306742908544 0.10228373765174163 0.0011273918429648745 0.2724511872329776 0.10008533464672367 1.3382988785397297e-11 10.87344688596625 -0.417227454661377 LNHNAAFMQIPMGLEGNFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNHNAAFMQIPMGLEGNFK 19 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 5403500.0 1167900.0 2637300.0 1598300.0 False True 1531128.20995969 2243825.1201148806 1432923.247976195 1.0 1.4654717387605012 0.9358610458975997 20.546163662174038 -6.674522055576587 1.9207852666013778 1.2959276090553806 0.9379243442222036 0.2995516087007052 0.19751523839590407 0.4507686869064404 3.2102435139189787 0.08264830159845024 0.21956643363701037 2.1158162311197305e-07 6.674522055576587 -0.358003264833177 LNHNAAFMQIPMGLEGNFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNHNAAFMQIPMGLEGNFK 19 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 5444600.0 2262700.0 1136100.0 2045800.0 False True 2190871.82703936 1589750.6546832332 1509943.6073155508 1.0 0.7256246737316198 0.6891976010098303 21.06307365387886 -13.999999999560904 0.2845880064012186 3.293683984915722 0.6787184692028558 0.9996153691598963 0.0027207108721181076 15.651875714346948 0.16906586758211573 20.951543472987055 0.01410257736010146 1.0000000010110556e-14 13.999999999560904 -2.614965515712866 LNHNAAFMQIPMGLEGNFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNHNAAFMQIPMGLEGNFK 19 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 7989800.0 1167900.0 2779900.0 4042000.0 False True 1599704.1913107713 2657074.8261000197 3087362.8476030575 1.0 1.6609788487975745 1.9299585913276398 20.60937372369693 -10.619371502579991 0.18738284679515096 2.0380406842090866e-17 2.181483448702976 0.9994555263814728 0.009117397616781134 2.447478557500088 0.09867534996387432 1.2965181231465768 0.18172430270775422 2.402306948300106e-11 10.619371502579991 2.181483448702976 LNHVAAGLVSPSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNHVAAGLVSPSLK 14 0 Q5T760;Q05519-2;Q05519;Q5T757 Q5T760 SRSF11 Serine/arginine-rich splicing factor 11 0 27495300.0 7029500.0 7503800.0 12962000.0 False True 9215742.573774826 6384262.289583309 11620816.580283677 1.0 0.6927561440085098 1.260974521288491 23.135668987414572 -6.7598238421085535 1.6129192664621903 0.8215016330190278 1.2630494342055518 0.690362172008874 0.12922485957612773 0.28319695830914077 1.4519679564433439 0.06321285764100626 0.1519498549810338 1.738505855951792e-07 6.7598238421085535 0.44154780118652404 LNHVAAGLVSPSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNHVAAGLVSPSLK 14 0 Q5T760;Q05519-2;Q05519;Q5T757 Q5T760 SRSF11 Serine/arginine-rich splicing factor 11 0 17961100.0 7029500.0 2558500.0 8373100.0 False True 9628496.115094652 2445457.0101719126 6395546.229407511 1.0 0.2539812013153492 0.6642310650550269 23.198879048937464 -10.5306258872147 6.050440303311975 1.0007819734495922 0.45910613318976107 0.6985906067844804 0.1674838055347563 0.0017690055318397978 0.000137233628938741 0.16238057103126918 0.05405516579962935 2.9469591294637436e-11 10.5306258872147 -0.5416758402598312 LNHVAAGLVSPSLK(ub)SDTSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNHVAAGLVSPSLKSDTSSK 20 1 Q5T760;Q05519-2;Q05519;Q5T757 Q5T760 SRSF11 Serine/arginine-rich splicing factor 11 1 4941200.0 1727400.0 2199500.0 1014300.0 True False 2264638.128165395 1871343.173583847 909349.965852627 1.0 0.8263320970842436 0.40154316689408565 21.110849106390187 -6.955928412364546 0.4894587943304293 1.0093419438329452 0.20053701943053664 0.9995881029492794 0.0051019487652551815 0.08118901464377995 0.026759798662153406 0.0061089522845103935 0.035035319960813376 1.1068062111392316e-07 6.955928412364546 -0.8088049244024085 down LNHVAAGLVSPSLK(ub)SDTSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNHVAAGLVSPSLKSDTSSK 20 1 Q5T760;Q05519-2;Q05519;Q5T757 Q5T760 SRSF11 Serine/arginine-rich splicing factor 11 1 7381070.0 2042100.0 4458300.0 880670.0 True False 1698096.6303690458 4434282.252996738 1064814.0252419906 1.0 2.611325041044949 0.6270632696624429 20.695487127265555 -6.690712233599303 1.863845435045389 2.0095152767653026 0.6338520694046621 0.3737997443308728 0.6813772495779332 0.41512813267856785 2.7965642759789544 0.2923935295840584 0.7607413168012814 2.0383922825587503e-07 6.690712233599303 -1.3756632073606405 LNHVAAGLVSPSLK(ub)SDTSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNHVAAGLVSPSLKSDTSSK 20 1 Q5T760;Q05519-2;Q05519;Q5T757 Q5T760 SRSF11 Serine/arginine-rich splicing factor 11 1 10153400.0 2213200.0 5164700.0 2775500.0 True False 2865031.0286942204 4877279.904863826 2270387.4790349193 1.0 1.7023480220689677 0.7924477802495847 21.450119332983796 -6.700569039229252 1.8287378546508262 1.435887921801306 0.7951192292895864 0.4202932104241637 0.29643955062549293 0.39435823224440414 2.564395846604445 0.1292980184335462 0.3322996616861666 1.9926497120507184e-07 6.700569039229252 -0.6407686925117196 LNIIHVTGTK(ub)GK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNIIHVTGTKGK 12 1 Q05932-3;Q05932-2;Q05932-4;Q05932;Q5JU21;Q5JU20;Q5JU23 Q05932-3 FPGS Folylpolyglutamate synthase, mitochondrial 1 3277760.0 980950.0 927210.0 1369600.0 True False 1286034.9495333119 788873.8822362726 1227886.930130884 1.0 0.613415586040291 0.9547850395329232 20.2944984194809 -10.238145626830919 7.810223819986438 1.0000002421022582 0.7841003127866071 0.34782332933434934 0.13936349580495028 5.875210880059268e-07 5.71538180789729e-08 0.13493827538312053 0.044979374860151626 5.7790223379343854e-11 10.238145626830919 -0.21589992931565116 LNIIIIAEGAIDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNIIIIAEGAIDR 13 0 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 0 9575800.0 2041100.0 3413400.0 4121300.0 False True 3096497.9243978127 2804252.100984073 3306723.2485700366 1.0 0.9056205330831688 1.0678913176449512 21.562206048332307 -6.748999937829064 1.6532858471425935 0.9444391935891252 1.0681948779561505 0.6447996873770825 0.03965715206395012 0.30177416315062583 1.6225483043711177 0.018950180403290058 0.04605901157508861 1.782379022602528e-07 6.748999937829064 0.12375568436702533 LNIIK(ub)VAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNIIKVAAK 9 1 O15247 O15247 CLIC2 Chloride intracellular channel protein 2 1 28904200.0 3907200.0 11352000.0 13645000.0 True False 5122377.03737862 9658325.849749427 12233146.29208231 1.0 1.8855163880502013 2.3881776376115083 22.288382017093 -9.122654876586616 0.16903755955783836 1.363342922500731e-16 3.083295554730067 0.9997371420442143 0.009303941068556662 0.5792257310533743 0.0586609507170795 0.6385830422347185 0.33921959382661615 7.539544752787554e-10 9.122654876586616 3.083295554730067 LNIIK(ub)VAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNIIKVAAK 9 1 O15247 O15247 CLIC2 Chloride intracellular channel protein 2 1 46182000.0 14570000.0 15182000.0 16430000.0 True False 14107483.325214792 21244251.773084067 12126490.110565312 1.0 1.5058853009674293 0.859578553524938 23.749957308555867 -6.697901622585318 1.8383136762833214 1.3147779559495578 0.8615727594205248 0.407636988912914 0.21362355489238244 0.39990665034907746 2.625901637422344 0.09275822194849939 0.23917298117050528 2.0049261365474609e-07 6.697901622585318 -0.453205196529033 LNIIK(ub)VAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNIIKVAAK 9 1 O15247 O15247 CLIC2 Chloride intracellular channel protein 2 1 49363000.0 10320000.0 14240000.0 24803000.0 True False 15656194.493060334 11698760.742372181 19900676.178458933 1.0 0.7472288842322252 1.2711055797933515 23.9002302476465 -6.775485394958581 1.553233396444934 0.8560350971262207 1.2746987460221633 0.7511590831871364 0.1067094763545915 0.25765827729603724 1.227395957035174 0.054126621057927364 0.1282184842856514 1.6769287288245987e-07 6.775485394958581 0.41866364889594254 LNIIK(ub)VAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNIIKVAAK 9 1 O15247 O15247 CLIC2 Chloride intracellular channel protein 2 1 25907500.0 3907200.0 8329300.0 13671000.0 True False 5351797.4281097995 7961283.984688255 10442191.36308298 1.0 1.4875906817534572 1.9511559440266513 22.35159207861589 -6.971738382117848 0.21260569319402597 0.765221204242699 2.686504504260752 0.9999929530392028 0.001030899656972701 0.07574256368205383 0.006974878761476935 0.013598722355912723 0.0477512073700665 1.0672388295618956e-07 6.971738382117848 1.921283300018053 LNIIK(ub)VAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNIIKVAAK 9 1 O15247 O15247 CLIC2 Chloride intracellular channel protein 2 1 47725100.0 14570000.0 26081000.0 7074100.0 True False 12115600.560441224 25940496.476326857 8553261.603057181 1.0 2.141082181350997 0.7059709141439119 23.530362583990144 -6.694880370275178 1.8493893582892484 1.7120914806543506 0.7106579753069338 0.39327098442991304 0.48212972988816427 0.4062320483304524 2.697530217446791 0.20828127981031727 0.5390033190677229 2.0189224146592402e-07 6.694880370275178 -1.0014335053474168 LNIIK(ub)VAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNIIKVAAK 9 1 O15247 O15247 CLIC2 Chloride intracellular channel protein 2 1 34166000.0 10320000.0 12129000.0 11717000.0 True False 13359443.437612668 11454010.48775212 9584626.226572553 1.0 0.8573718314869373 0.7174420305255864 23.67135656973895 -6.9713601800818035 0.22332937726866411 1.0618770263350708 0.5089702265998568 0.9999911323765726 0.00034346367228642023 0.07586381009390428 0.007431228554594273 0.003779008705200407 0.014084347743937428 1.0681686311504943e-07 6.9713601800818035 -0.552906799735214 LNIISNLDCVNEVIGIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNIISNLDCVNEVIGIR 17 0 P30153;B3KQV6;P30154;P30154-2;P30154-4;P30154-3;P30154-5;H0YDG7 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 0 15882000.0 0.0 15882000.0 0.0 False True 0.0 13047733.01336763 0.0 0.0 LNIK(ub)FVPAEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNIKFVPAEAR 11 1 Q9H089;F8WFC6 Q9H089 LSG1 Large subunit GTPase 1 homolog 1 4968900.0 1158500.0 1462800.0 2347600.0 True False 1121724.0516308385 2046903.6684012273 1732693.133509625 1.0 1.8247836136038091 1.544669681451974 20.097286380468812 -10.12228035659804 4.494027037572419 0.9999359213502041 1.6847266472881248 0.8884820250828389 0.11435603429181093 79777281.68888997 10.304355245078273 64230.79589408938 0.039147112174339964 7.546049390114696e-11 10.12228035659804 0.6847907259379207 LNIK(ub)FVPAEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNIKFVPAEAR 11 1 Q9H089;F8WFC6 Q9H089 LSG1 Large subunit GTPase 1 homolog 1 4154300.0 1158500.0 1960600.0 1035200.0 True False 963344.0802519658 1950037.8586513684 1251655.5337759985 1.0 2.024238170583173 1.2992819070924524 19.87769165590309 -10.024166219855253 4.38978356246655 0.9999680349784162 1.661760038396558 0.5262920853794295 0.2959621555861478 33836171.100400284 15453129.445436776 10581.4613669313 0.101315717334004 9.458750722409491e-11 10.024166219855253 0.6617920034181418 LNIK(ub)FVPAEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNIKFVPAEAR 11 1 Q9H089;F8WFC6 Q9H089 LSG1 Large subunit GTPase 1 homolog 1 13658400.0 3411400.0 5132000.0 5115000.0 True False 4416124.548747271 4846399.6886094315 4184122.4843320507 1.0 1.097432745637624 0.9474647823325016 22.07434943059926 -6.73133656343289 1.718183412210419 1.058546605899291 0.9475291457327314 0.5655213230492613 0.040954311446428186 0.33374165059560074 1.930778068901979 0.0188835768693906 0.046790681087396556 1.856365277638252e-07 6.73133656343289 -0.11101746016655956 LNILDTLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNILDTLSK 9 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 8545220.0 867720.0 3586600.0 4090900.0 False True 1137589.323012434 3051493.2604572987 3667612.910683733 1.0 2.682420798726102 3.224021917656171 20.117548398862056 -9.748161695044374 0.30344180482731775 7.562967270534884e-26 3.418329590035614 0.9987844160066887 0.03301504504453844 1.125428513974551 0.12939658496250578 1.2423705763207082 0.18876283359298837 1.785822559680184e-10 9.748161695044374 3.418329590035614 LNILDTLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNILDTLSK 9 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 7759200.0 2979500.0 1243100.0 3536600.0 False True 2884917.4033958437 1739476.3126808628 2610258.3642742117 1.0 0.6029553257342206 0.9047948344038099 21.460098583717627 -9.762823520764 5.873299312036797 1.0000000133305424 0.7538750800677612 0.46992873546496383 0.12322546341326353 2.157988753157889e-08 4.540622413640736e-09 0.11931254901669186 0.039770847301704645 1.726539343325503e-10 9.762823520764 -0.2461249332627813 LNILDTLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNILDTLSK 9 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 13133520.0 867720.0 7042200.0 5223600.0 False True 1188539.5332512902 6731052.318558785 3989893.263418934 1.0 5.663296954158322 3.3569714357792084 20.180758460384947 -9.951843298536755 11.278097164359538 1.0000173012054885 4.510134194968765 0.7554103980825193 0.9415534501844413 0.0 0.0 0.911655221592664 0.30388506933605913 1.1172663053611278e-10 9.951843298536755 3.5101168937632767 LNILK(ub)LAPGGHVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNILKLAPGGHVGR 14 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 81562100.0 11410200.0 19696900.0 50455000.0 True False 14958882.696533967 16758199.297914835 45234400.598535195 1.0 1.1202841574389628 3.023915723934127 23.834499086204005 -6.919784058725835 0.8263258415034929 0.9576696768383016 3.329374796123441 0.9941207296211836 0.07108157453396348 0.0982990854919339 0.1062736611247775 0.06117405819063323 0.18286907658957935 1.2028623769804484e-07 6.919784058725835 2.3717051192851395 up LNILK(ub)LAPGGHVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNILKLAPGGHVGR 14 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 96339900.0 12216000.0 13580900.0 70543000.0 True False 11828209.766700327 19003824.193457887 52065672.05536269 1.0 1.6066526184680028 4.401821837987851 23.495728398400843 -6.941643889333026 0.6440877200878561 0.9692985085269977 5.193500203423481 0.9983713989754469 0.05978702125076967 0.08702460229642921 0.051253890217848756 0.05895045783271246 0.23888619943011327 1.1438158508991599e-07 6.941643889333026 4.224201694896483 LNILK(ub)LAPGGHVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNILKLAPGGHVGR 14 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 134105100.0 17712100.0 49101000.0 67292000.0 True False 26870550.627958667 40338542.922135994 53991706.70486865 1.0 1.5012175775871133 2.0093263979745384 24.679522549391645 -6.970955309133462 0.2342498437694147 0.8040333912393892 2.7211035184840884 0.9999889044308876 0.0013725568144099328 0.07599394258043646 0.007912436010755693 0.012656399006854845 0.05005813344445275 1.0691648954656419e-07 6.970955309133462 1.917070127244699 LNILK(ub)LAPGGHVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNILKLAPGGHVGR 14 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 124850800.0 11410200.0 10968600.0 102472000.0 True False 15628859.289060814 10483970.983690295 78270224.0770858 1.0 0.6708084569568294 5.008057378305905 23.897709147726896 -6.888592977054585 1.0306457004640794 0.7590338401995657 5.371010925893471 0.9799832250573279 0.27894229773653967 0.12029317370089829 0.22856330039596498 0.20658638086653078 0.5124941110883171 1.2924299779802135e-07 6.888592977054585 4.611977085693906 up LNILK(ub)LAPGGHVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNILKLAPGGHVGR 14 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 91586000.0 12216000.0 14442000.0 64928000.0 True False 10158145.26055936 14364198.07948744 78504144.60684688 1.0 1.414057164082774 7.728196692722235 23.27613367383512 -6.9202249169040675 0.8230559667828811 0.8618084341293364 8.751697979106913 0.9942431684286575 0.23359658356429228 0.09803971882671227 0.10492961771740003 0.20150712783730362 0.6049144135622709 1.201641954718171e-07 6.9202249169040675 7.889889544977576 up LNILK(ub)LAPGGHVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNILKLAPGGHVGR 14 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 124885100.0 17712100.0 38472000.0 68701000.0 True False 22928662.60768788 36330999.38039401 56198122.931788124 1.0 1.5845232668831015 2.4509987299889504 24.450648871484095 -6.9654530292016315 0.35018983450038055 0.9164482610789776 3.148320253784592 0.9999221820875047 0.005258319153544863 0.0778075639418434 0.014319751125078361 0.011887989985847528 0.07446658851897682 1.0827968178833131e-07 6.9654530292016315 2.2318719927056145 LNIPWNHIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNIPWNHIR 9 0 Q9NRN7;E9PLW6;E9PNF3;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 7310200.0 1927900.0 1888900.0 3493400.0 False True 2527495.5698101562 1607083.4828745332 3131936.4790590247 1.0 0.6358402768615905 1.2391461795101262 21.26927713270132 -6.743271999414806 1.6746836269531056 0.7841536241866428 1.2397614724340622 0.6195690627900279 0.15299800472144118 0.3119204703460811 1.7188697134328548 0.07223827651058704 0.1766358615125674 1.8060426439684092e-07 6.743271999414806 0.4556078482474194 LNIPWNHIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNIPWNHIR 9 0 Q9NRN7;E9PLW6;E9PNF3;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 7117700.0 1927900.0 3037000.0 2152800.0 False True 2640696.7295385143 2902815.2979840143 1644352.9783077363 1.0 1.099261140256461 0.6226966390779384 21.33248719422421 -6.852351202681585 1.223663183068602 1.0530957889678136 0.6027604327384912 0.9436625117776815 0.04872847598651083 0.15488780643040595 0.44510948452492016 0.03114043837672134 0.07217877521223873 1.404910949592207e-07 6.852351202681585 -0.4503353562293224 LNIPWNHIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNIPWNHIR 9 0 Q9NRN7;E9PLW6;E9PNF3;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 4853180.0 1719100.0 2260000.0 874080.0 False True 1429507.8190428622 2247824.931425125 1056846.0867107075 1.0 1.5724467550867776 0.7393076642409181 20.447087080488366 -6.721772466657643 1.7527202251290266 1.3476009553070283 0.7404545344368422 0.5209852787846148 0.2408362741795661 0.3518755215055676 2.1134637140430796 0.10905821524700572 0.2732302606496323 1.897699894026399e-07 6.721772466657643 -0.6071464208701861 LNISFPATGCQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNISFPATGCQK 12 0 P62753;A2A3R7 P62753 RPS6 40S ribosomal protein S6 0 120833000.0 29427000.0 36405000.0 55001000.0 False True 38579081.971473396 30973515.905578528 49310024.12684637 1.0 0.802857774803489 1.2781544196232502 25.20131547760994 -6.7940593752091605 1.4800950131635313 0.8903965015461919 1.2837889540086416 0.8142085852317191 0.08404166692583562 0.22934929820334107 0.9924270655451065 0.04468396166277909 0.10431444355692938 1.6067215726921488e-07 6.7940593752091605 0.3933924524624497 LNISFPATGCQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNISFPATGCQK 12 0 P62753;A2A3R7 P62753 RPS6 40S ribosomal protein S6 0 49218000.0 23806000.0 10409000.0 15003000.0 False True 23050291.560745563 14565367.982217893 11073264.219647666 1.0 0.6318951733791768 0.480395841868887 24.458281663481397 -13.999999999999998 0.12197545132206114 2.7522052606751575 0.24490668911667682 0.9996833059836342 0.0038827913828655084 11.956619280498964 0.1077348811386273 5.065721553647871 0.20900963253490565 1.0000000000000041e-14 13.999999999999998 -2.5072985715584806 LNISFPATGCQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNISFPATGCQK 12 0 P62753;A2A3R7 P62753 RPS6 40S ribosomal protein S6 0 114150600.0 23506000.0 83557000.0 7087600.0 False True 35660320.51878645 68645600.51617916 5686732.753394565 1.0 1.9249855166056489 0.15946947954095642 25.08781633433052 -6.7643262539296884 1.596031526403511 1.5343774510184913 0.1515662355398816 0.708445305387518 0.3893333695188262 0.2757034385432669 1.3850358996139789 0.19237905792840224 0.46039271834456336 1.720575545813263e-07 6.7643262539296884 -1.3828112154786096 LNISFPATGCQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNISFPATGCQK 12 0 P62753;A2A3R7 P62753 RPS6 40S ribosomal protein S6 0 132171000.0 29427000.0 55118000.0 47626000.0 False True 40306957.13477356 52682704.509148054 36377719.68825914 1.0 1.3070375005732622 0.9025171403195654 25.26452553913283 -6.703800908277246 1.817704934241255 1.1899504274746862 0.9036474577627595 0.435430498000149 0.12951725137623568 0.387681023113963 2.492923845986248 0.056793344545512624 0.14535500250627867 1.9778761414363037e-07 6.703800908277246 -0.2863029697119267 LNISFPATGCQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNISFPATGCQK 12 0 P62753;A2A3R7 P62753 RPS6 40S ribosomal protein S6 0 40966700.0 23806000.0 6301700.0 10859000.0 False True 19795743.784616567 6267751.491310482 13129566.693656823 1.0 0.31662116662578765 0.6632520018702159 24.238686938915674 -10.628622552541739 6.676860367464555 1.001690397394386 0.4899365842485013 0.7427347864901561 0.1415114459105988 0.003570241322277835 0.00019858232100295655 0.13737896896264426 0.04567262277579004 2.3516757858712982e-11 10.628622552541739 -0.5117538131458848 LNISFPATGCQK(ub)LIEVDDER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNISFPATGCQKLIEVDDER 20 1 P62753;A2A3R7 P62753 RPS6 40S ribosomal protein S6 1 87487800.0 5450800.0 31870000.0 50167000.0 True False 8269262.106857864 26182549.49855345 40251470.461022764 1.0 3.1662498007941653 4.867601237073066 22.979327168095296 -7.72240995899042 0.23083645116095045 1.0383685936113987e-15 6.781411886590356 0.9998178681526302 0.021360053022374054 0.1340158172514917 0.03208236984424281 0.27190631843681934 0.49570409058485776 1.8949163411173776e-08 7.72240995899042 6.781411886590355 LNISFPATGCQK(ub)LIEVDDER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNISFPATGCQKLIEVDDER 20 1 P62753;A2A3R7 P62753 RPS6 40S ribosomal protein S6 1 71774800.0 5450800.0 21702000.0 44622000.0 True False 7056168.051331302 20494264.622408774 36501253.86038409 1.0 2.9044467866014156 5.172956992357534 22.750453490187745 -6.968804819819982 0.2852905328655436 0.531024049397719 7.616010670641663 0.9999715019959371 0.009105958239795164 0.07669243331509358 0.010411558519253046 0.04066574953433017 0.2068661506752599 1.0744721920369575e-07 6.968804819819982 7.084986621243944 LNITSLQFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNITSLQFK 9 0 Q3B726 Q3B726 TWISTNB DNA-directed RNA polymerase I subunit RPA43 0 9090100.0 3211300.0 2356700.0 3522100.0 False True 4210045.398273441 2005089.5463446479 3157666.8783688643 1.0 0.4762631650402023 0.7500315506487978 22.005404359744308 -10.08911724872219 5.802254255093632 1.0000020061907404 0.6131473578444664 0.7269504205996709 0.11176547540788015 2.900637947420515e-06 4.552343933614456e-07 0.10821701732384438 0.03607215207795547 8.144843637893369e-11 10.08911724872219 -0.38685464834627403 LNITSLQFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNITSLQFK 9 0 Q3B726 Q3B726 TWISTNB DNA-directed RNA polymerase I subunit RPA43 0 4121890.0 1443800.0 934490.0 1743600.0 False True 1397967.359296164 1307636.7303009727 1286898.8531212222 1.0 0.9353843075129664 0.920550000372783 20.414899245394245 -13.999999999998803 0.2067471204373759 1.368789924782307 0.9115320231299132 0.9994884170699014 0.0007801351971299634 12.672568745677735 0.1441414676367571 1.8955235980012186 0.008991769252664757 1.0000000000027568e-14 13.999999999998803 -0.4572579016523938 LNITSLQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNITSLQFK 9 0 Q3B726 Q3B726 TWISTNB DNA-directed RNA polymerase I subunit RPA43 0 7844300.0 3211300.0 2111200.0 2521800.0 False True 4398604.392119427 2017920.2031952068 1926202.7781012857 1.0 0.4587637403378508 0.4379122572496597 22.0686144212672 LNITSLQFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNITSLQFK 9 0 Q3B726 Q3B726 TWISTNB DNA-directed RNA polymerase I subunit RPA43 0 4092900.0 1443800.0 1627400.0 1021700.0 False True 1200583.6711849715 1618632.8731863936 1235332.746192946 1.0 1.3482049706613195 1.0289434846083467 20.195304520828522 -9.738716280853417 7.280685813089856 0.999999998722569 1.1885742276348379 0.3174846699973204 0.13033795589209543 2.8964511182104164e-10 9.892970574416328e-19 0.12619918313719308 0.04206639437906436 1.8250876198322653e-10 9.738716280853417 0.18857422891226894 LNITYPMLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNITYPMLFK 10 0 Q92890;Q92890-1;C9IZG3;Q92890-3;C9J6N9 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 0 17735100.0 3623800.0 4769500.0 9341800.0 False True 4750836.892929124 4057909.191365382 8375200.1488731885 1.0 0.8541461815717025 1.7628894314048882 22.17975024591051 -6.8657939844832505 1.1561798339758838 0.9192832690489544 1.8120086599965697 0.9602984524004675 0.07939843378938444 0.14094783640829028 0.35480021292565317 0.05342281823723534 0.1256302093854584 1.3620906618119877e-07 6.8657939844832505 0.8927253909476153 LNITYPMLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNITYPMLFK 10 0 Q92890;Q92890-1;C9IZG3;Q92890-3;C9J6N9 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 0 19112500.0 7402200.0 3137700.0 8572600.0 False True 7167221.212759427 4390599.972889335 6327178.887512617 1.0 0.6125944550271423 0.882793861064128 22.772982452599987 -10.146870414608104 5.454837181937077 1.0000056007259541 0.7476941580455781 0.5375903457965829 0.1103084455991511 7.51356878073567e-06 1.1749885499607277e-06 0.1068080640665965 0.03560189772926586 7.130657639420176e-11 10.146870414608104 -0.252311442680376 LNITYPMLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNITYPMLFK 10 0 Q92890;Q92890-1;C9IZG3;Q92890-3;C9J6N9 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 0 15216300.0 3623800.0 5075900.0 6516600.0 False True 4963616.789512777 4851629.954243352 4977513.293589832 1.0 0.9774384606994575 1.0027996730340698 22.2429603074334 -6.671995404707656 1.9299555645990394 0.9856243061637981 1.002698943335228 0.28809607744841537 0.009579177113500774 0.45653232226998597 3.2801016067585946 0.003992813355041839 0.010641444818994662 2.128161564051008e-07 6.671995404707656 0.017074637171429874 LNITYPMLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNITYPMLFK 10 0 Q92890;Q92890-1;C9IZG3;Q92890-3;C9J6N9 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 0 13734000.0 7402200.0 3234900.0 3096900.0 False True 6155257.273060944 3217472.9516226207 3744447.4715522514 1.0 0.5227194914669433 0.6083332191393809 22.553387728034263 -10.82798509657262 7.3411287049085105 1.023723561710216 0.5655263553031625 0.9717020905960924 0.034951657962511366 0.012330230646727086 0.00028891751788556925 0.030747672582596346 0.011280599100928703 1.485986635138265e-11 10.82798509657262 -0.4581972064070535 LNIWDVGGQK(ub)SLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNIWDVGGQKSLR 13 1 P36404;V9GYD0;P36404-2 P36404 ARL2;ARL2-SNX15 ADP-ribosylation factor-like protein 2 1 269200800.0 122247800.0 145106000.0 1847000.0 True False 160268049.64937937 123456750.41875787 1655890.1576750467 1.0 0.7703141748392516 0.010332004172370355 27.255911603763526 -7.290131701066733 0.8021212347265806 0.989991225523967 3.572192400007321e-22 0.9895869905035864 0.04315677197252348 0.1019942053979486 0.1284578945805808 0.037018023966566886 0.0684376817327264 5.1270588086228884e-08 7.290131701066733 -0.989991225523967 down LNIWDVGGQK(ub)SLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNIWDVGGQKSLR 13 1 P36404;V9GYD0;P36404-2 P36404 ARL2;ARL2-SNX15 ADP-ribosylation factor-like protein 2 1 394705000.0 259088000.0 134057600.0 1559400.0 True False 250863393.2576012 187587498.78114846 1150946.3590027718 1.0 0.7477675253659773 0.004587940647924318 27.902326722796147 -7.3344744126212955 0.7873883971486836 0.989734704683488 2.9082196937724865e-21 0.9885207166828016 0.04527043280115979 0.10701043347620769 0.1337213850192885 0.038908698157106285 0.07055069030282875 4.629409381194452e-08 7.3344744126212955 -0.989734704683488 down LNIWDVGGQK(ub)SLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNIWDVGGQKSLR 13 1 P36404;V9GYD0;P36404-2 P36404 ARL2;ARL2-SNX15 ADP-ribosylation factor-like protein 2 1 276860800.0 122247800.0 152290000.0 2323000.0 True False 167446115.28257632 145561324.2443153 1774355.2436867645 1.0 0.8693024857499441 0.010596574549922662 27.319121665286417 -7.143248961867122 0.9167775366930411 0.9949398634910971 3.153401285362308e-20 0.990827513309608 0.04203090862395061 0.08640625771555567 0.13606303448468557 0.0354828190710539 0.06491536617068677 7.190366678347572e-08 7.143248961867122 -0.9949398634910971 down LNIWDVGGQK(ub)SLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNIWDVGGQKSLR 13 1 P36404;V9GYD0;P36404-2 P36404 ARL2;ARL2-SNX15 ADP-ribosylation factor-like protein 2 1 389491100.0 259088000.0 130403100.0 0.0 True False 215443151.54451582 129700592.61731128 0.0 1.0 0.6020177094861703 0.0 27.682731998230423 -7.646768506287671 0.6629770407349768 0.9981727424827457 3.419409555929363e-21 0.9872601001530459 0.046398076313126486 0.12103191302141947 0.14867728999893357 0.04254091668691428 0.07755632979832135 2.255441118531568e-08 7.646768506287671 -0.9981727424827457 down LNK(ub)ASINMLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNKASINMLR 10 1 P18124;A8MUD9;C9JIJ5 P18124 RPL7 60S ribosomal protein L7 1 8637630.0 899030.0 3196800.0 4541800.0 True False 1363894.2378969018 2626306.0632875967 3644111.2392583396 1.0 1.9255936349854437 2.6718429757995663 20.37930034537435 -6.973570323175804 0.1501158675228216 0.13391696192517438 4.483148702448777 0.9999985397648218 0.0008263271380643402 0.07516030381336955 0.004588953170451036 0.038041117170738006 0.09304968506521208 1.0627464840157056e-07 6.973570323175804 4.349231740523603 LNK(ub)CGVISPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNKCGVISPR 10 1 P62244;I3L3P7 P62244 RPS15A 40S ribosomal protein S15a 1 18114000.0 5474670.0 764430.0 11874900.0 True False 7177345.386779698 650380.0237248015 10646199.260084156 1.0 0.09061567873308259 1.4833059698776527 22.775018916786763 -6.730471000347715 1.7213489651483402 0.4530569154883044 1.482586379213902 0.5616407013688309 0.38226575673853674 0.33529467857350376 1.9465275872816508 0.1759645726100545 0.436438791077669 1.8600687636181926e-07 6.730471000347715 1.0295294637255976 LNK(ub)CGVISPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNKCGVISPR 10 1 P62244;I3L3P7 P62244 RPS15A 40S ribosomal protein S15a 1 14779760.0 3995000.0 4751860.0 6032900.0 True False 3868180.911752438 6649302.478622531 4452702.506879451 1.0 1.7189740165513963 1.1511102010123413 21.88322383941933 -10.210867304825054 4.2887096047175275 0.9998330006517786 1.43504210875074 0.4390063934402285 0.23182943208173734 163144707.42212966 94.30420428743793 289250.1073987681 0.07936138087627265 6.153648637580303e-11 10.210867304825054 0.4352091080989613 LNK(ub)CGVISPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNKCGVISPR 10 1 P62244;I3L3P7 P62244 RPS15A 40S ribosomal protein S15a 1 78680800.0 10650800.0 30233600.0 37796400.0 True False 16158042.27777972 24838177.863805 30325924.97324935 1.0 1.5372021830863793 1.876831639124566 23.94574907472483 -8.855630985662938 0.11415259224888635 1.225522381043016e-12 2.7586289532466908 0.9999478542861144 0.002606712032343528 0.36834116644813825 0.034550447947388596 0.45413402765637934 0.33691829524660555 1.394341053096279e-09 8.855630985662938 2.758628953245465 LNK(ub)CGVISPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNKCGVISPR 10 1 P62244;I3L3P7 P62244 RPS15A 40S ribosomal protein S15a 1 30021450.0 5474670.0 6218980.0 18327800.0 True False 7498803.446393811 5944204.900183271 13999151.112889513 1.0 0.7926871190418853 1.8668513200758359 22.838228978309655 -6.856682228254831 1.2024216879791405 0.8883706696904141 1.915656287585386 0.949472178286439 0.10458396465280405 0.1502615664075628 0.4147271466286014 0.0679244128933808 0.15800618110219392 1.3909700268327125e-07 6.856682228254831 1.0272856178949719 LNK(ub)CGVISPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNKCGVISPR 10 1 P62244;I3L3P7 P62244 RPS15A 40S ribosomal protein S15a 1 9949910.0 3995000.0 4794910.0 1160000.0 True False 3322019.508508073 4769078.868114878 1402550.636765996 1.0 1.4355962859040172 0.4221981939521736 21.663629114853606 -6.789881690080533 1.4967230291922586 1.243485660232737 0.4114405432279369 0.8009912341340933 0.1851659813888547 0.23551276995693043 1.0422643402882255 0.09737713362095107 0.22801148828718376 1.6222519688717162e-07 6.789881690080533 -0.8320451170048002 down LNK(ub)CGVISPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNKCGVISPR 10 1 P62244;I3L3P7 P62244 RPS15A 40S ribosomal protein S15a 1 120010400.0 10650800.0 22855600.0 86504000.0 True False 13787670.558655499 21583665.768312883 70761159.60599405 1.0 1.5654323677441861 5.132205567645526 23.71687539681728 -6.934784385428411 0.7064137468042994 0.9541752861549442 5.962455582693964 0.9973978902626063 0.09331367531130833 0.0902284535871965 0.06605970591183045 0.08757823854250488 0.314675184771044 1.1620253824396368e-07 6.934784385428411 5.008280296539019 up LNK(ub)DQWEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNKDQWEER 9 1 P26038 P26038 MSN Moesin 1 3684260.0 1477000.0 921560.0 1285700.0 True False 1430113.4434689246 1289543.713871912 948936.5998267682 1.0 0.9017072874610265 0.6635393885431914 20.44769816236878 -6.95612821866775 0.48694430161101515 1.0053593919183517 0.5498400776276194 0.99959855635586 0.0028303008324509086 0.08111433730563176 0.026470795423140986 0.003406813532739699 0.019643704121974748 1.106297118800289e-07 6.95612821866775 -0.4555193142907322 LNK(ub)HEENLK(ub)TK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNKHEENLKTK 11 2 P42766 P42766 RPL35 60S ribosomal protein L35 2 6825310.0 687610.0 1273300.0 4864400.0 True False 901463.3688247132 1083328.6032845257 4361078.550619655 1.0 1.201744453240424 4.837776776559907 19.78190934303436 -6.918340340733449 0.8369497714050749 0.9148744830622066 5.402295033317691 0.9937072286397097 0.13989457693085366 0.09915808816743553 0.11074897640697348 0.11948604016164624 0.3524277743495435 1.2068676862697382e-07 6.918340340733449 4.487420550255485 up LNK(ub)HEENLK(ub)TK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNKHEENLKTK 11 2 P42766 P42766 RPL35 60S ribosomal protein L35 2 6858540.0 921140.0 1474600.0 4462800.0 True False 891898.9149065444 2063415.4699374153 3293858.7988698008 1.0 2.3135082187577565 3.69308533043225 19.766520683206867 -6.970505752724372 0.2458086710549856 0.5389819460315224 5.507803832452034 0.9999860624030378 0.004104984956807767 0.076138945596212 0.008440963034350674 0.031664644695625827 0.13314451217627163 1.0702722058448137e-07 6.970505752724372 4.968821886420512 LNK(ub)HEENLK(ub)TK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNKHEENLKTK 11 2 P42766 P42766 RPL35 60S ribosomal protein L35 2 7676110.0 687610.0 1276300.0 5712200.0 True False 941837.9989615545 1219908.8458402997 4363096.006451809 1.0 1.2952427563820303 4.632533420038735 19.845119404557252 -6.924274450204024 0.7923751515223069 0.937076382264754 5.227434674081372 0.9952882975004987 0.11306815206527172 0.09572177495863687 0.0930554535415261 0.09969406162386237 0.3120118649279726 1.1904894464716776e-07 6.924274450204024 4.290358291816617 up LNK(ub)HEENLK(ub)TK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNKHEENLKTK 11 2 P42766 P42766 RPL35 60S ribosomal protein L35 2 4386540.0 921140.0 1208500.0 2256900.0 True False 765968.7234210589 1201989.5706315322 2728807.3552734246 1.0 1.5692410589078183 3.562557153881828 19.546925958641143 -6.9479328778900316 0.5810941363878012 0.9762694418366782 4.254306938115674 0.9990289251977518 0.03423740432656545 0.08432656058863332 0.0394805108094172 0.03582953178129255 0.16656311377303132 1.1273716829314229e-07 6.9479328778900316 3.2780374962789955 LNK(ub)NVPTNVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNKNVPTNVR 10 1 Q8IWZ3;Q8IWZ3-4;Q8IWZ3-6;A0A0A0MQZ8;H0Y7Y3;H0Y785;H0Y472;H0Y4P6 Q8IWZ3 ANKHD1 Ankyrin repeat and KH domain-containing protein 1 1 5362000.0 2223400.0 1525600.0 1613000.0 True False 3373060.3523130147 1253344.7604327945 1294189.8429969868 1.0 0.37157495850121275 0.38368416447381964 21.68562670125974 -9.95984568283579 5.275348673962869 1.0000018649922549 0.3776295614854117 0.9997161610503094 0.004943562649721463 13573580.674452517 8.413831347602256 334.2261742076581 0.0016923129841350476 1.096867875216265e-10 9.95984568283579 -0.6223723035068431 LNK(ub)NVPTNVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNKNVPTNVR 10 1 Q8IWZ3;Q8IWZ3-4;Q8IWZ3-6;A0A0A0MQZ8;H0Y7Y3;H0Y785;H0Y472;H0Y4P6 Q8IWZ3 ANKHD1 Ankyrin repeat and KH domain-containing protein 1 1 1903800.0 453990.0 861060.0 588750.0 True False 377512.80016710435 856421.2988729713 711854.9029275683 1.0 2.2685887696890816 1.8856444142091842 18.5261660365554 -10.088183214977036 4.975449273412854 0.999968699253139 2.0771165919543075 0.9134090530397257 0.1563363784853828 5.4283926065265544e-05 9.947979656895919e-06 0.15137642603480136 0.05045734918745906 8.162379539800166e-11 10.088183214977036 1.0771478927011686 LNK(ub)QQTDIAVNWAGGLHHAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNKQQTDIAVNWAGGLHHAK 20 1 Q13547;Q5TEE2 Q13547 HDAC1 Histone deacetylase 1 1 14201700.0 2997800.0 2726500.0 8477400.0 True False 3880711.1954724067 2574767.8782138806 6934600.18546951 1.0 0.6634783544876621 1.7869405467637092 21.887889640333835 -6.826417242175507 1.3439205700917443 0.8196949618864573 1.8150021472637539 0.8985004055862421 0.14998525074611113 0.18527575937719978 0.655709761680982 0.08765842248716307 0.20177408364639413 1.4913609175397802e-07 6.826417242175507 0.9953071853772966 LNK(ub)SELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNKSELK 7 1 P26447 P26447 S100A4 Protein S100-A4 1 25326600.0 5685100.0 9522500.0 10119000.0 True False 7453221.154586717 8101780.118414279 9071982.948302016 1.0 1.0870172708384533 1.2171895560510924 22.829432637770854 -6.9653027592218875 0.352826265661931 0.9878225022499352 1.3207958740098937 0.9999192372882418 0.0008020410080516648 0.0778584809686179 0.014499113144473075 0.001774387342411379 0.011168002795621688 1.0831715406021951e-07 6.9653027592218875 0.33297337175995856 LNK(ub)SELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNKSELK 7 1 P26447 P26447 S100A4 Protein S100-A4 1 11111900.0 3677800.0 2576300.0 4857800.0 True False 5579491.483195466 2116539.1362762246 3897653.7007506257 1.0 0.3793426592102347 0.6985679093676788 22.411702209639756 -10.578362360743958 6.559169013255803 1.0007909526955705 0.5389552842890224 0.7355328601214067 0.13032316264967556 0.0015097500760530018 9.70496734003031e-05 0.12638325008265275 0.0420616198806062 2.6402049396383422e-11 10.578362360743958 -0.4618356684065481 LNK(ub)SELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNKSELK 7 1 P26447 P26447 S100A4 Protein S100-A4 1 24837400.0 5685100.0 7817300.0 11335000.0 True False 7787035.104050739 7471905.837645835 8657906.451652817 1.0 0.9595315467062713 1.1118360628872803 22.892642699293745 -6.836036077711312 1.300705478941827 0.9784490129170754 1.1164640820952463 0.9174161559760025 0.01851071182979146 0.17348045626768455 0.5718353207338095 0.011166038776523975 0.025703093916210697 1.4586930786902126e-07 6.836036077711312 0.13801506917817086 LNK(ub)VISELNGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNKVISELNGK 11 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 35802300.0 11554300.0 14517700.0 9730300.0 True False 15147799.192000382 12351715.749551373 8723501.895628337 1.0 0.8154132222768287 0.5758923646304511 23.85260486547221 -6.967554197736074 0.31111862253973205 1.0364161193555612 0.3472635376534447 0.9999565256286619 0.001144781554741873 0.0771046574518074 0.011857161867355309 0.0037707001886482044 0.02124194855828176 1.0775707699674801e-07 6.967554197736074 -0.6891525817021165 LNK(ub)VISELNGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNKVISELNGK 11 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 55829000.0 26429000.0 17005600.0 12394400.0 True False 25590025.861503184 23796024.763032436 9147934.815970218 1.0 0.9298945179586713 0.3574804834305415 24.609078269589816 -6.9297181402374415 0.7491060310712011 1.0087964284894122 0.2408074332254983 0.996482473764621 0.017068416568332835 0.09278457062954831 0.07840022941551482 0.015524118335308923 0.051874169392440016 1.1756603180971634e-07 6.9297181402374415 -0.7679889952639138 down LNK(ub)VISELNGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNKVISELNGK 11 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 52277800.0 19940900.0 26088000.0 6248900.0 True False 30251803.175064627 21432392.57352568 5013802.176009838 1.0 0.7084666143534729 0.16573564712805344 24.850517801778675 -7.257772377955787 0.5114169754998321 1.0096230836618336 1.0996332268126812e-22 0.9986734600920436 0.012590798664278941 0.0949232063813738 0.045378888683331224 0.013676878588042961 0.05337452345472529 5.523668694669529e-08 7.257772377955787 -1.0096230836618336 down LNK(ub)VISELNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNKVISELNGK 11 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 28224900.0 11554300.0 9972100.0 6698500.0 True False 15826236.953216923 9531499.64867512 5116452.259937932 1.0 0.6022593795891383 0.32328924905284795 23.9158149269951 -8.094154415669308 0.2116903830620612 1.2420235179311985 6.807860357138961e-10 0.9997711443458646 0.004200743675525801 0.09214111267102046 0.04056684449618047 0.08696793057114248 0.10625304826373878 8.050921355933551e-09 8.094154415669308 -1.2420235172504124 down LNK(ub)VISELNGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNKVISELNGK 11 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 54896400.0 26429000.0 24468600.0 3998800.0 True False 21976884.503218997 24336782.795163173 4834930.591637807 1.0 1.1073809297945993 0.22000072807997992 24.389483545024092 -6.8766499844934055 1.0982610172940241 1.064021240610208 0.16100460478006323 0.9708836317201653 0.06747641124531488 0.1306413797598228 0.29054130256187444 0.04746041261010136 0.1138606441657722 1.3284646898802878e-07 6.8766499844934055 -0.9030166358301448 down LNK(ub)VISELNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNKVISELNGK 11 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 62996300.0 19940900.0 38070000.0 4985400.0 True False 25813888.143904123 35951371.03378041 4078108.3545237584 1.0 1.3927142952415026 0.15798117400174727 24.621644123871125 -6.821160955651709 1.3668730995388192 1.2114252313829323 0.13035505262869493 0.88702576573436 0.1731275400662764 0.19197781975900635 0.7044734940610706 0.09952498511508477 0.22931774392745283 1.5095206008862246e-07 6.821160955651709 -1.0810701787542374 down LNLAFIANLFNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNLAFIANLFNR 12 0 P13796 P13796 LCP1 Plastin-2 0 214670000.0 104080000.0 89699000.0 20891000.0 False True 136449887.9121539 76316258.84396347 18729399.72062233 1.0 0.5592988020121767 0.1372621114403573 27.02379596859812 -7.796401333523073 0.4099073058784922 1.0464275633104818 1.0047254101427413e-18 0.9977818380571993 0.01658951613978494 0.11324204358364579 0.07438541653526969 0.033379837037232116 0.07856664904329252 1.598080552478761e-08 7.796401333523073 -1.0464275633104818 down LNLAFIANLFNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNLAFIANLFNR 12 0 P13796 P13796 LCP1 Plastin-2 0 2389470000.0 1375500000.0 372220000.0 641750000.0 False True 1331835505.4106328 520849387.1016573 473656422.9126776 1.0 0.3910763641498418 0.3556418348875895 30.310768760582288 -13.815913292395532 0.40623596233993503 9.999870872138771 0.353834232704512 0.9998434270600739 0.003700755852375679 23.681785660911444 0.21052016110863866 187.23165553804787 0.008917071078819476 1.5278710697499962e-14 13.815913292395532 -9.646036639434259 LNLAFIANLFNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNLAFIANLFNR 12 0 P13796 P13796 LCP1 Plastin-2 0 97476077630.0 36216684000.0 33227891830.0 28031501800.0 False True 54943357422.25826 27298114922.232777 22491063182.586277 1.0 0.4968410414463307 0.40934999675638417 35.67722602070796 -13.999999999999998 0.24609298313022288 4.431498446671028 0.372840266405305 0.9995355004538612 0.005609524783451007 13.84653995841091 0.15698561510877737 23.43374829925308 0.04127302408527753 1.0000000000000041e-14 13.999999999999998 -4.058658180265723 LNLAFIANLFNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNLAFIANLFNR 12 0 P13796 P13796 LCP1 Plastin-2 0 232625000.0 104080000.0 40520000.0 88025000.0 False True 142561188.65624204 38729692.41827862 67235307.93178122 1.0 0.27167066144255836 0.47162420968518853 27.08700603012101 -10.721239297173891 7.414547268623313 1.0053866526185937 0.3716474355645039 0.9294134938639741 0.08163069424223733 0.00726951136271774 0.00027330764442364436 0.07904698905310513 0.02634619327829458 1.900031070322378e-11 10.721239297173891 -0.6337392170540899 LNLAFIANLFNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNLAFIANLFNR 12 0 P13796 P13796 LCP1 Plastin-2 0 4042100000.0 1375500000.0 1138800000.0 1527800000.0 False True 1143789194.9819412 1132665058.365898 1847255916.250938 1.0 0.9902743122029414 1.6150317946307435 30.091174036016564 -6.9033680174882335 0.9397602896434042 0.9763698388378124 1.6852796371230696 0.9881677164233806 0.0317896675250081 0.10896798509097361 0.16378115045086514 0.025201617989216003 0.06674847250851355 1.2492000200012768e-07 6.9033680174882335 0.7089097982852572 LNLAFIANLFNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNLAFIANLFNR 12 0 P13796 P13796 LCP1 Plastin-2 0 81010114210.0 36216684000.0 20950887920.0 23842542290.0 False True 46883211375.571045 19784952589.941353 19503444238.36305 1.0 0.42200506342128463 0.4160006037582466 35.44835234280042 LNLAFVANLFNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNLAFVANLFNK 12 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3;H7C4N2 P13797 PLS3 Plastin-3 0 682570000.0 379950000.0 106040000.0 196580000.0 False True 367888695.2241147 148382324.99129492 145089800.7264108 1.0 0.40333483175095025 0.3943850480048682 28.454694103812372 LNLAFVANLFNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNLAFVANLFNK 12 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3;H7C4N2 P13797 PLS3 Plastin-3 0 3509040000.0 1494800000.0 968840000.0 1045400000.0 False True 2267720884.5180798 795942932.4185294 838776231.7849036 1.0 0.3509880505367739 0.3698763095190855 31.078595935491354 -10.211026357411214 8.386597056314264 1.0000001545548771 0.36043218007766625 0.9993462854382952 0.007711099439367421 2.2292485652666114e-08 2.0960110703008755e-09 0.007466241707428191 0.0024887466424682804 6.151395386463252e-11 10.211026357411214 -0.6395679744772109 LNLAFVANLFNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNLAFVANLFNK 12 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3;H7C4N2 P13797 PLS3 Plastin-3 0 872580000.0 379950000.0 171360000.0 321270000.0 False True 315945259.6389592 170436849.66770294 388446071.6153545 1.0 0.5394505676789283 1.2294727006166963 28.23509937924665 -6.726760867121728 1.7345917295513766 0.7218616697026833 1.228861454557819 0.5444291663879585 0.1936576925708822 0.34232221383535105 2.016203802895859 0.08852098314551456 0.22050658568491172 1.8760272089585972e-07 6.726760867121728 0.5069997848551356 LNLAFVANLFNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNLAFVANLFNK 12 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3;H7C4N2 P13797 PLS3 Plastin-3 0 2559010000.0 1494800000.0 661090000.0 403120000.0 False True 1935048066.9131212 624299760.3551848 329756296.3604962 1.0 0.322627520747377 0.17041245744687822 30.849722257583803 -13.999999999999995 0.20977618332050604 4.913886522196932 0.0805631099016614 0.99948988731377 0.008144138638874518 12.741476465110333 0.14517277579527774 20.55182420772617 0.09030638908692405 1.0000000000000123e-14 13.999999999999995 -4.83332341229527 LNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESK 34 1 Q14651 Q14651 PLS1 Plastin-1 0 128651000.0 64758000.0 30508000.0 33385000.0 False True 98242620.44395351 25063609.039908014 26786440.116834715 1.0 0.2551195084846761 0.2726560020059331 26.54984570670991 -9.857295332324684 6.637692779450568 1.0000000191435348 0.2638877554347668 0.9995745248899622 0.007159243500924933 2.0329040200015113e-09 3.4235639389639513e-10 0.006931907919155257 0.002310635904189639 1.3890077460824082e-10 9.857295332324684 -0.736112263708768 LNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNLAFVANLFNTYPCLHKPNNNDIDMNLLEGESK 34 1 Q14651 Q14651 PLS1 Plastin-1 0 95116000.0 64758000.0 14658000.0 15700000.0 False True 83830507.57101941 13842269.414582428 12842761.095603768 1.0 0.16512209952749662 0.15319913320009015 26.32097202880236 LNLCLYCGTGGHYADNCPAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNLCLYCGTGGHYADNCPAK 20 0 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7;B4DSP0;A0A087WZG9;Q86TG7-2 A0A087WUL4;B4DSP0 PEG10 Retrotransposon-derived protein PEG10 0 3741600.0 1584000.0 2157600.0 0.0 False True 2076639.3394778213 1835694.490258927 0.0 1.0 0.8839736661834208 0.0 20.98581924707257 -7.135298996478082 0.9524644102403681 0.9957353023906087 6.146480217121494e-20 0.9896963702722629 0.04533050431171591 0.08667284440229185 0.1489579899133573 0.03778995547348769 0.06645643544012585 7.323201828525054e-08 7.135298996478082 -0.9957353023906087 down LNLCLYCGTGGHYADNCPAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNLCLYCGTGGHYADNCPAK 20 0 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7;B4DSP0;A0A087WZG9;Q86TG7-2 A0A087WUL4;B4DSP0 PEG10 Retrotransposon-derived protein PEG10 0 6260000.0 1584000.0 1778200.0 2897800.0 False True 2169647.6059904615 1699633.2442789504 2213399.3220643643 1.0 0.7833683403637588 1.0201653558638293 21.04902930859546 -11.816377431796512 16.348738668068634 0.9182359524714958 0.9115901634160064 0.0 0.10961403122887152 0.0 0.0 0.0 0.03195127848431377 1.5262390748971812e-12 11.816377431796512 -0.006645789055489404 LNLDSIIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNLDSIIGR 9 0 P62136;P62136-2;P62136-3;E9PMD7 P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase 0 12841000.0 1288400.0 8222700.0 3329900.0 False True 1689104.8768833482 6995905.211833565 2985353.890656278 1.0 4.141782613725003 1.7674177201860335 20.687827477488412 -6.574954546040831 2.287020102389957 3.1459730825465653 1.7728536466927358 0.0 1.3666362789701587 0.7146853671242104 7.024065770332434 0.5033915331155855 1.5295564085061009 2.661003550137511e-07 6.574954546040831 -1.3731194358538295 LNLDSIIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNLDSIIGR 9 0 P62136;P62136-2;P62136-3;E9PMD7 P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase 0 8119300.0 3320900.0 2856100.0 1942300.0 False True 3215479.847268759 3996555.624364741 1433553.3622489958 1.0 1.2429111094443435 0.44582875040148723 21.616602616867553 -6.82492646950436 1.3502955666254868 1.1303242660420607 0.4265023750094573 0.8953480357170523 0.10791143738155973 0.18717117822480797 0.6691656717428536 0.06277497423835135 0.1445412207735761 1.4964890055339571e-07 6.82492646950436 -0.7038218910326034 down LNLDSIIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNLDSIIGR 9 0 P62136;P62136-2;P62136-3;E9PMD7 P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase 0 11774100.0 1288400.0 3092200.0 7393500.0 False True 1764756.2977008265 2955576.379462021 5647307.573912232 1.0 1.6747787687810651 3.2000495373042166 20.751037539011303 -6.957583184842346 0.46826166600768987 0.9590252927545401 3.97814800527579 0.9996697652793317 0.01672339405760726 0.08057615104341785 0.02440973256773211 0.021021112530649342 0.1259051634836496 1.1025970219926199e-07 6.957583184842346 3.01912271252125 LNLDSIIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNLDSIIGR 9 0 P62136;P62136-2;P62136-3;E9PMD7 P62136 PPP1CA Serine/threonine-protein phosphatase PP1-alpha catalytic subunit;Serine/threonine-protein phosphatase 0 4105720.0 3320900.0 0.0 784820.0 False True 2761475.490814638 0.0 948922.2334023165 1.0 0.0 0.3436287001491306 21.39700789230183 -10.545195913603514 6.277166531523698 1.0011567691866787 0.17181435007458454 0.8856475098472409 0.140285829390202 0.002273579578694387 0.0001647291996028654 0.13598269449368694 0.045277056744762276 2.84973244113302e-11 10.545195913603514 -0.8293424191120942 LNLEAINYMAADGDFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNLEAINYMAADGDFK 16 0 P09382 P09382 LGALS1 Galectin-1 0 1566200.0 0.0 1566200.0 0.0 False True 0.0 1332529.0649997853 0.0 0.0 LNLEAINYMAADGDFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNLEAINYMAADGDFK 16 0 P09382 P09382 LGALS1 Galectin-1 0 19274200.0 7271900.0 3740500.0 8261800.0 False True 7041057.5149368085 5234101.156449807 6097786.731312749 1.0 0.7433686126474968 0.8660327966895573 22.747360696620973 -10.17130931471722 5.235299780926437 1.0000089589373262 0.8047007046684291 0.7716845624104689 0.05007744343665801 5.236738034029272e-06 8.289560546638266e-07 0.04848949952704593 0.016162425370852423 6.740477840549435e-11 10.17130931471722 -0.19530825426889709 LNLEAINYMAADGDFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNLEAINYMAADGDFK 16 0 P09382 P09382 LGALS1 Galectin-1 0 2075890.0 769890.0 0.0 1306000.0 False True 1054539.1384949477 0.0 997549.6979142998 1.0 0.0 0.945957965427453 20.00818121008378 -11.815086930957467 16.875903467134385 0.8514567856156793 0.5256810844423844 0.0 0.4753776368624583 0.0 0.0 0.0 0.13471483648981933 1.5307810208118111e-12 11.815086930957467 -0.3257757011732949 LNLEAINYMAADGDFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNLEAINYMAADGDFK 16 0 P09382 P09382 LGALS1 Galectin-1 0 12584900.0 7271900.0 2691000.0 2622000.0 False True 6046907.049792204 2676503.0488783205 3170248.0772417537 1.0 0.44262348120107053 0.5242759730118054 22.52776597205525 -10.706293202326362 6.824978484943808 1.0051117548041153 0.48344972710663203 0.9816045035229266 0.033334490193847086 0.0026016399137552037 0.00011195905108865135 0.03238617505831372 0.010758660447923687 1.9665581721812692e-11 10.706293202326362 -0.5216620276974833 LNLGTVGFYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNLGTVGFYR 10 0 E9PLK3;P55786;P55786-2;H0YCQ5 E9PLK3 NPEPPS Puromycin-sensitive aminopeptidase 0 83543000.0 30056000.0 18812000.0 34675000.0 False True 39403707.06271803 16005322.92860165 31087163.626086757 1.0 0.40618825287494714 0.7889400755265487 25.23182802763473 -9.908571577612287 5.459745581913202 1.0000004423592772 0.5975641641990134 0.5957962871363123 0.15625777727568574 8.414032899490515e-07 1.6806231998234972e-07 0.15129610910047697 0.05043198075777224 1.2343218654456142e-10 9.908571577612287 -0.40243627816026384 LNLGTVGFYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNLGTVGFYR 10 0 E9PLK3;P55786;P55786-2;H0YCQ5 E9PLK3 NPEPPS Puromycin-sensitive aminopeptidase 0 57891800.0 21255000.0 6153800.0 30483000.0 False True 20580271.65939878 8611044.431643058 22498587.829602115 1.0 0.41841257366058576 1.0932114114891802 24.29475869013053 -6.678654707157981 1.9064984489104622 0.631580114094817 1.090626303563853 0.3180215673442731 0.24656340047466244 0.44153589337117405 3.1016289343004355 0.10381433774649296 0.27429309201532925 2.0957780758316978e-07 6.678654707157981 0.4590461894690361 LNLGTVGFYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNLGTVGFYR 10 0 E9PLK3;P55786;P55786-2;H0YCQ5 E9PLK3 NPEPPS Puromycin-sensitive aminopeptidase 0 66897000.0 30056000.0 15246000.0 21595000.0 False True 41168515.43285939 14572381.308220046 16494705.76298568 1.0 0.3539690745464394 0.40066311815121064 25.29503808915762 -9.921352438469047 7.094871261478547 1.0000000138484784 0.3773160963488234 0.9958002713223687 0.01906276347649888 4.18598539061783e-09 6.202504648469372e-10 0.01845744191936381 0.006152480456430051 1.198526280863351e-10 9.921352438469047 -0.622683917499655 LNLGTVGFYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNLGTVGFYR 10 0 E9PLK3;P55786;P55786-2;H0YCQ5 E9PLK3 NPEPPS Puromycin-sensitive aminopeptidase 0 41332700.0 21255000.0 8519700.0 11558000.0 False True 17674474.25615498 8473802.68507195 13974724.361845993 1.0 0.47943732652308024 0.7906727045631593 24.075163965564805 -10.307518727277104 5.967183913252093 1.000026919332611 0.6350550155431232 0.6470452487061462 0.12706131101673895 4.550723302544367e-05 5.2809705645913225e-06 0.12303564331548897 0.041008861792925545 4.9258510205597944e-11 10.307518727277104 -0.36497190378948785 LNLHYAVVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNLHYAVVSK 10 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQQ5;A0A1B0GTT3 P47897 QARS Glutamine--tRNA ligase 0 66298700.0 18565000.0 18682000.0 29051700.0 False True 24338894.78371575 15894718.421865623 26045708.767584313 1.0 0.6530583480931184 1.0701270127109686 24.536760321735063 -6.685872981599183 1.880780904219707 0.7816601530037495 1.0686306725162766 0.3513392581912168 0.14685609978523423 0.4255871134746354 2.91536928088603 0.06253709920355331 0.1637212288574572 2.0612326752350529e-07 6.685872981599183 0.28697051951252717 LNLHYAVVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNLHYAVVSK 10 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQQ5;A0A1B0GTT3 P47897 QARS Glutamine--tRNA ligase 0 34314100.0 12311700.0 3332000.0 18670400.0 False True 11920871.822583873 4662484.976150456 13780062.140006008 1.0 0.39111946219549676 1.155960935164149 23.50698641411598 -6.69467554366179 1.8504226763890028 0.6199442120472631 1.1534317734410915 0.3921518097387965 0.25727560562252105 0.4066738140355411 2.70340568571681 0.1110955783330992 0.2875412674883254 2.0198748250396427e-07 6.69467554366179 0.5334875613938284 LNLHYAVVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNLHYAVVSK 10 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQQ5;A0A1B0GTT3 P47897 QARS Glutamine--tRNA ligase 0 27104700.0 7418600.0 9671100.0 10015000.0 False True 11254558.572307883 7945216.6443508165 8035530.860269568 1.0 0.7059554218234927 0.7139801004760141 23.424006136549462 -10.514625428632943 6.173984905143982 1.0002922476301266 0.7099677611497534 0.9994261794679974 0.0032760613414137764 1.3191684698707387e-05 1.037075727553084e-06 0.0031751740428554694 0.0010573442513707788 3.0575570656176583e-11 10.514625428632943 -0.29032448648037323 LNLHYAVVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNLHYAVVSK 10 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQQ5;A0A1B0GTT3 P47897 QARS Glutamine--tRNA ligase 0 47744000.0 18565000.0 12998300.0 16180700.0 False True 25428982.20026068 12423992.126369977 12359151.91197695 1.0 0.48857606759591876 0.48602621271449287 24.599970383257954 LNLHYAVVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNLHYAVVSK 10 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQQ5;A0A1B0GTT3 P47897 QARS Glutamine--tRNA ligase 0 24645600.0 12311700.0 6303900.0 6030000.0 False True 10237724.050788214 6269939.639473825 7290845.120430119 1.0 0.6124349131085531 0.7121548778088806 23.287391689550255 -9.983439523942012 6.8817065679671385 1.0000000341088213 0.6622948954587186 0.9386182523883642 0.04071050511402856 2.1298092540654092e-08 3.158042018057937e-09 0.039417781192162896 0.013139259026859912 1.0388682560743972e-10 9.983439523942012 -0.33770513865010277 LNLHYAVVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNLHYAVVSK 10 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQQ5;A0A1B0GTT3 P47897 QARS Glutamine--tRNA ligase 0 40762000.0 7418600.0 22713800.0 10629600.0 False True 9603523.942468343 21449757.062965106 8695121.86890635 1.0 2.233529815874233 0.9054095060309174 23.19513245864191 -6.662767655044471 1.9632647460157884 1.7921889124733397 0.9109338054162152 0.24742263082813398 0.5248625269289823 0.47787107676453194 3.543714086126008 0.21578404707113466 0.5819596963357454 2.173863872014873e-07 6.662767655044471 -0.8812551070571245 LNLNNTVLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNLNNTVLSK 10 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 12891700.0 2336600.0 3599300.0 6955800.0 False True 3063305.2276665843 3062298.469961511 6236080.540745038 1.0 0.9996713492028216 2.035735937908889 21.5466576935258 -6.906820459171078 0.9170961251828086 0.9646067706442115 2.1609165460386386 0.9896657400789134 0.04964224233276721 0.1065591089318073 0.15044313456422737 0.040014273317784496 0.10817177464158378 1.2393088208681328e-07 6.906820459171078 1.1963097753944272 up LNLNNTVLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNLNNTVLSK 10 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 8506000.0 3179700.0 1310900.0 4015400.0 False True 3078762.16397978 1834349.2062531882 2963646.2805820988 1.0 0.5958073760014011 0.9626096862094485 21.553918992049592 -10.36743844448129 8.393815040685626 1.0000010823745944 0.7792085311054249 0.3257377207693696 0.14974641608063094 3.0332429074909436e-06 2.285704148965552e-07 0.14499205466518014 0.048330447969544166 4.291030046241237e-11 10.36743844448129 -0.22079255126916952 LNLNNTVLSK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNLNNTVLSKR 11 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 23596700.0 8295500.0 8295800.0 7005400.0 True False 10875480.833736278 7058098.976775122 6280548.408541846 1.0 0.6489919006505488 0.5774961589798655 23.374575851941778 -13.999999999999998 0.22367373508502317 3.152893716996525 0.540573635521075 0.9995018374579584 0.004121081683873102 13.10219581829431 0.1497957630368874 12.483713461815817 0.038630428217482395 1.0000000000000041e-14 13.999999999999998 -2.61232008147545 LNLNNTVLSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNLNNTVLSKR 11 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 29254700.0 7549700.0 10137000.0 11568000.0 True False 7310038.905996839 14184756.963756649 8537993.767438807 1.0 1.9404489013211803 1.1679819871320531 22.80144765393408 -10.273168262443804 4.812902010568395 0.9998240016108084 1.5542154442273703 0.40699805188137683 0.31535829716020214 0.000595741887790581 8.996689208150213e-05 0.3054401351722915 0.10178145274878035 5.331283009890739e-11 10.273168262443804 0.5543914426165619 LNLNNTVLSK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNLNNTVLSKR 11 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 43540300.0 7975300.0 10991000.0 24574000.0 True False 12099113.172529444 9029570.17692504 19716938.12883316 1.0 0.7463001666457936 1.6296184561360816 23.528397970514582 -6.829906191177786 1.3282464864178378 0.8644261249348184 1.653355150417311 0.905694472086928 0.1140352702317803 0.18093335912924044 0.6243117947649879 0.06740795964887923 0.15513202312498206 1.4794279142230974e-07 6.829906191177786 0.7889290254824926 LNLNNTVLSK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNLNNTVLSKR 11 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 27283400.0 8295500.0 6638900.0 12349000.0 True False 11362570.527458252 6345571.446093524 9432420.535638342 1.0 0.5584626674711602 0.83013086808521 23.43778591346467 -10.38280643940668 5.9614135664425225 1.0000639667027993 0.6942967677781852 0.6280239265471596 0.11090807847408035 9.431022482622216e-05 9.763936465455031e-06 0.10740867158253209 0.035795428407498095 4.14184231350244e-11 10.38280643940668 -0.3057671989246141 LNLNNTVLSK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNLNNTVLSKR 11 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 25121400.0 7549700.0 11338000.0 6233700.0 True False 6277910.058418871 11276919.943583217 7537137.848627736 1.0 1.7962856808470073 1.2005807312451382 22.581852929368356 -10.224227829245162 4.868483056043444 0.9999166800815862 1.498433206046891 0.482789368513041 0.24319552729884467 0.00021998687531639012 3.5053901590490475e-05 0.2355122114727596 0.07849101892461617 5.967221662651533e-11 10.224227829245162 0.4985165259653048 LNLNNTVLSK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNLNNTVLSKR 11 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 26535100.0 7975300.0 7950800.0 10609000.0 True False 10324183.066665903 7508330.990685099 8678270.85753249 1.0 0.7272566693366319 0.840577002702748 23.299524292607032 -10.0397044961572 4.8610882738386465 1.0000046402322271 0.7839168361112379 0.8290021161917247 0.04626283238223633 64021364.85436652 5.566999774247776 3325.175891964603 0.01583699804202399 9.126316034402449e-11 10.0397044961572 -0.21608780412098927 LNLQFLTLHDYLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNLQFLTLHDYLLR 14 0 O60306;H0YH15 O60306 AQR Intron-binding protein aquarius 0 21527500.0 11407000.0 5219200.0 4901300.0 False True 11044891.028876109 7303253.777768441 3617502.4941517795 1.0 0.6612336652914533 0.3275272236452191 23.396875849054513 -7.33511739774503 0.2726791051929741 1.0997215361937562 7.564565736080617e-13 0.9998969854950088 0.0027864511780102607 0.1098164288235525 0.019822574865934476 0.016136622639398752 0.05122481538584249 4.6225604824071326e-08 7.33511739774503 -1.0997215361929997 down LNLQFLTLHDYLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNLQFLTLHDYLLR 14 0 O60306;H0YH15 O60306 AQR Intron-binding protein aquarius 0 96089000.0 34190000.0 24676000.0 37223000.0 False True 51868729.62381127 20272375.005532023 29865857.73457954 1.0 0.3908400138688885 0.5757969773153859 25.62836169965664 -10.406856862361632 5.263190797180986 1.0003902989761315 0.48331849559213313 0.9123193621534765 0.07550836413646514 0.00034606804323360614 3.9000557566888526e-05 0.0731642315652333 0.024370219733318037 3.918710112574138e-11 10.406856862361632 -0.5170718033839984 LNLQFLTLHDYLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNLQFLTLHDYLLR 14 0 O60306;H0YH15 O60306 AQR Intron-binding protein aquarius 0 6620680.0 3241400.0 803180.0 2576100.0 False True 4439833.175541335 767692.8518389201 1967678.2364448884 1.0 0.17291029223081514 0.44318742588903143 22.082074038390363 -10.31055429312604 5.655063347233341 1.0000873406224553 0.30804885910235347 0.897322015067718 0.11034017776746406 0.00012151881494009991 1.4814942057052054e-05 0.10684976301398709 0.035612139242575995 4.891541099345027e-11 10.31055429312604 -0.6920384815201018 LNLQFLTLHDYLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNLQFLTLHDYLLR 14 0 O60306;H0YH15 O60306 AQR Intron-binding protein aquarius 0 37060000.0 11407000.0 13768000.0 11885000.0 False True 9485425.915782627 13693829.05126596 14370098.549968846 1.0 1.4436704448327458 1.5149660835006578 23.17728112448879 -11.912025047260006 0.29864873169656536 1.7731881055763826e-10 1.5345083897977154 0.999454141529485 0.005322689925358202 4.966308909720056 0.16354487781767804 3.1206319656754737 0.025889146454751887 1.224545573463598e-12 11.912025047260006 1.5345083896203966 LNLQFLTLHDYLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNLQFLTLHDYLLR 14 0 O60306;H0YH15 O60306 AQR Intron-binding protein aquarius 0 69991000.0 34190000.0 19157000.0 16644000.0 False True 44259628.98565665 18090896.10964362 13614962.781861728 1.0 0.40874486578968816 0.30761583623473143 25.39948802174909 -13.999999999999998 0.24843372516335963 5.079667229779114 0.26634329881321744 0.999539770028308 0.006550888355064861 13.936456785872883 0.15772383137259866 28.3470288375368 0.047080428662710734 1.0000000000000041e-14 13.999999999999998 -4.813323930965896 LNLQVLLSHVLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNLQVLLSHVLGK 13 0 Q5VU43-13;Q5VU43-2 Q5VU43-13 0 127689000.0 42246000.0 42654000.0 42789000.0 False True 64090270.596300945 35042060.44277685 34331735.39491507 1.0 0.5467610000198587 0.5356778037522683 25.933602025301365 LNLQVLLSHVLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNLQVLLSHVLGK 13 0 Q5VU43-13;Q5VU43-2 Q5VU43-13 0 95463000.0 42246000.0 27720000.0 25497000.0 False True 54688279.79315735 26177357.632161666 20856807.62131266 1.0 0.478664857098632 0.38137618700382464 25.704728347393814 -13.999999999999968 0.23606964924261176 4.386191239818601 0.3367250073399766 0.9995186568669947 0.005959006972994122 13.487967269725758 0.1538009656173539 21.4819298134646 0.048662235278117 1.0000000000000737e-14 13.999999999999968 -4.049466232478624 LNLVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNLVQR 6 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;Q9BYZ2;P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 A0A5F9ZHM4;P00338 LDHB;LDHAL6B;LDHA L-lactate dehydrogenase B chain;L-lactate dehydrogenase;L-lactate dehydrogenase A-like 6B;L-lactate dehydrogenase A chain 0 43404700.0 2955700.0 20905000.0 19544000.0 False True 3874951.323039514 17786055.487051778 17521774.359285947 1.0 4.590007461848678 4.521805023744623 21.88574675675606 -10.118737375942825 4.311688729208703 0.9994440363760793 4.555906243116556 0.9997241704973192 0.027843530203765253 4892739.772052592 8339368.909689272 36713.54851384639 0.010189688453077295 7.607861961120405e-11 10.118737375942825 3.556462206740476 LNLVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNLVQR 6 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;Q9BYZ2;P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 A0A5F9ZHM4;P00338 LDHB;LDHAL6B;LDHA L-lactate dehydrogenase B chain;L-lactate dehydrogenase;L-lactate dehydrogenase A-like 6B;L-lactate dehydrogenase A chain 0 41632900.0 14010000.0 4933900.0 22689000.0 False True 13565260.218686266 6904031.999948596 16746070.244590152 1.0 0.5089494700911251 1.234482050076879 23.69341338692217 -6.7244291422716875 1.7434682744084222 0.702667012759105 1.2336345028241797 0.5332576767030603 0.2065322731138268 0.34679912137672253 2.0624544313989692 0.09397658543442534 0.23468828631261898 1.8861266771753803e-07 6.7244291422716875 0.5309674900650747 LNLVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNLVQR 6 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;Q9BYZ2;P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 A0A5F9ZHM4;P00338 LDHB;LDHAL6B;LDHA L-lactate dehydrogenase B chain;L-lactate dehydrogenase;L-lactate dehydrogenase A-like 6B;L-lactate dehydrogenase A chain 0 47793700.0 2955700.0 21840000.0 22998000.0 False True 4048502.164789142 20875036.584778 17566346.0586777 1.0 5.156236982243341 4.338974105400437 21.94895681827895 -10.183046858412828 5.05383975550663 0.9997213924167433 4.747605543825957 0.9655605217793537 0.3336461723448828 0.0010474669441784476 0.0001693228269953175 0.3230720553603156 0.10768383908276485 6.56074475011671e-11 10.183046858412828 3.7478841514092136 LNLVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNLVQR 6 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8;Q9BYZ2;P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 A0A5F9ZHM4;P00338 LDHB;LDHAL6B;LDHA L-lactate dehydrogenase B chain;L-lactate dehydrogenase;L-lactate dehydrogenase A-like 6B;L-lactate dehydrogenase A chain 0 11928300.0 3918700.0 3458100.0 4551500.0 False True 5072834.39912526 3265653.6950857905 3723173.702333789 1.0 0.643753262603823 0.7339434740814323 22.274360634295434 -9.87072063402151 6.317031328609832 1.0000000228706731 0.688848368342575 0.9407215278156942 0.03681999965250168 1.1894138994365264e-08 2.102405937646277e-09 0.03565081402147852 0.011883603788430026 1.3467263759971864e-10 9.87072063402151 -0.3111516545280981 LNLVQRNVNIFKFIIPNVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNLVQRNVNIFKFIIPNVVK 20 2 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2 P00338 LDHA L-lactate dehydrogenase A chain 0 59601000.0 19824000.0 14318000.0 25459000.0 False True 19194697.971108966 20035252.067383617 18790524.14637141 1.0 1.0437909519357802 0.9789434652555669 24.19420452374459 -6.724789255791409 1.741933837375149 1.0265045232916175 0.9790152188253455 0.5350727745980248 0.018417428506724048 0.34609884169215316 2.0548014964245227 0.008386700177727864 0.020937261882625995 1.8845633642145173e-07 6.724789255791409 -0.047489304466271975 LNLVQRNVNIFKFIIPNVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNLVQRNVNIFKFIIPNVVK 20 2 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2 P00338 LDHA L-lactate dehydrogenase A chain 0 37757100.0 19824000.0 5115100.0 12818000.0 False True 16484534.352106139 5087543.941032148 15498184.536264246 1.0 0.3086252745975891 0.9401651393497886 23.974609799178868 -10.752177017926707 9.875476525682268 1.0013407909922258 0.6243952069737146 0.3204803809529484 0.2578250701448647 0.007631158802100787 0.00019150163873759776 0.25029654918858685 0.08321268357548499 1.7693876109808592e-11 10.752177017926707 -0.3769455840185112 LNLVQRNVNIFKFIIPNVVKYSPNCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNLVQRNVNIFKFIIPNVVKYSPNCK 26 3 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2 P00338 LDHA L-lactate dehydrogenase A chain 0 10540100.0 6891200.0 1263500.0 2385400.0 False True 6672442.628052162 1768022.1390654545 1760592.1795339321 1.0 0.2649737491383392 0.2638602199638379 22.669783564958486 LNLVQRNVNIFKFIIPNVVKYSPNCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNLVQRNVNIFKFIIPNVVKYSPNCK 26 3 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2 P00338 LDHA L-lactate dehydrogenase A chain 0 27943400.0 6891200.0 3151100.0 17901100.0 False True 5730338.131922609 3134124.398855619 21644137.24466528 1.0 0.5469353337800463 3.7771134523615566 22.450188840392762 -6.8713898717772395 1.12664744632171 0.7414479855141232 3.971411135450017 0.9660542425265886 0.2630930527933606 0.1355327894944412 0.320676383493608 0.1810638593232261 0.42976386971752456 1.344652699941848e-07 6.8713898717772395 3.2299631499358936 up LNLVVKPLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNLVVKPLEK 10 1 Q5HY81;P11441 Q5HY81 UBL4A Ubiquitin-like protein 4A 0 6990600.0 1543600.0 2492100.0 2954900.0 False True 2114310.6342215138 2381990.781727351 2257013.4780757753 1.0 1.1266039829593897 1.0674937927968207 21.011755922169744 -10.516144081485235 6.361843196671546 0.9999189458829238 1.0970488878781053 0.7823314576652325 0.024131634082862653 2.7765684666622702e-05 2.1117518680691612e-06 0.023384836528758796 0.007788451409974875 3.046883988065882e-11 10.516144081485235 0.09712994199518143 LNLYELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNLYELK 7 0 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 6285250.0 3284700.0 999050.0 2001500.0 False True 3180428.996453879 1397975.8749769235 1477247.106287063 1.0 0.439555756954688 0.46448045466009996 21.60078994782543 -10.393667027141094 5.896097007681894 1.0001458035782262 0.4520181058073999 0.9984507716305708 0.010175465228564719 1.9507543049191418e-05 2.006088594258276e-06 0.009854934345739953 0.0032841172808450677 4.0395498588788604e-11 10.393667027141094 -0.5481276977708264 LNLYELK(ub)EGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNLYELKEGR 10 1 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 416309000.0 121048000.0 166295000.0 128966000.0 True False 158695100.23049966 141484434.21283296 115621835.44922592 1.0 0.8915488506408279 0.7285784834017486 27.241682344220415 -6.965227723992208 0.35413089015986027 1.0150191411007794 0.5995739930280887 0.9999177505962223 0.0010116467730576716 0.0778838684069366 0.014588526373484048 0.002214621771140845 0.013970207035703593 1.0833587017344576e-07 6.965227723992208 -0.41544514807269073 LNLYELK(ub)EGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNLYELKEGR 10 1 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 531414000.0 167583000.0 175762000.0 188069000.0 True False 162263169.39529657 245944683.1867218 138808086.9509376 1.0 1.5157147743587145 0.8554503617070427 27.27376033224018 -6.698348157336981 1.837101174688388 1.3207644262858655 0.857497173453965 0.4095728191145265 0.21775724683657088 0.3989757013032119 2.616741657650363 0.09461218616221152 0.24378413062482987 2.0028657624496462e-07 6.698348157336981 -0.4632672528319005 LNLYELK(ub)EGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNLYELKEGR 10 1 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 1466222000.0 312899000.0 605625000.0 547698000.0 True False 474690658.9810155 497546486.98027766 439445250.23543864 1.0 1.0481488893173612 0.9257507851086945 28.822412419621756 -6.799966667737792 1.4558493273436743 1.0265663729969257 0.924058438103141 0.8321436205203121 0.020626932332054013 0.22078983165394925 0.9238481923777618 0.011145782745828652 0.025923813429476573 1.5850148382682875e-07 6.799966667737792 -0.10250793489378462 LNLYELK(ub)EGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNLYELKEGR 10 1 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 314328000.0 121048000.0 89211000.0 104069000.0 True False 165802716.79920045 85269363.03867352 79490045.56833315 1.0 0.5142820617465583 0.47942547084196196 27.304892405743306 -13.999999999999998 0.3739496188412926 7.93601971503268 0.4760332878991928 0.9997975838319673 0.003380571722627605 23.2883028921474 0.19884893384431002 129.70548083934528 0.009622933851580029 1.0000000000000041e-14 13.999999999999998 -7.4599864271334875 LNLYELK(ub)EGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNLYELKEGR 10 1 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 473617000.0 167583000.0 150460000.0 155574000.0 True False 139352689.6856844 149649442.11602837 188103804.10709715 1.0 1.073889872190976 1.349839780856565 27.054165607674456 -6.9464540171684055 0.596512386067046 0.9968664466481199 1.44090463974358 0.9988927456104247 0.005009713871484437 0.0849418176787422 0.04210291504656618 0.005159521597481058 0.023164118286621727 1.1312171555671828e-07 6.9464540171684055 0.4440381930954602 LNLYELK(ub)EGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNLYELKEGR 10 1 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 1 1311548000.0 312899000.0 646790000.0 351859000.0 True False 405053923.6613916 610795567.9258951 287824272.3782191 1.0 1.5079364307960512 0.7105826053393038 28.593538741714205 -6.734621177255918 1.706594921824307 1.3040886710308417 0.7106580816737944 0.5805008821703366 0.21345701023928337 0.32762036314626725 1.871364351623742 0.09904189719125757 0.244470368905307 1.8423783551006677e-07 6.734621177255918 -0.5934305893570473 LNMILVQILK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LNMILVQILK 10 0 O14980;C9JKM9 O14980 XPO1 Exportin-1 0 32703200.0 10805400.0 12047900.0 9849900.0 False True 14165984.039642433 10250400.282346385 8830726.834912533 1.0 0.723592533611602 0.6233754612599035 23.755927486174805 -13.999999999915236 0.14114725501166847 2.3217508023753095 0.5010492103070635 0.9995983986496872 0.0031916820753439125 11.935333056363085 0.11779136529580692 4.342271449473969 0.10944450361073531 1.0000000001951768e-14 13.999999999915236 -1.820701592068246 LNMILVQILK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LNMILVQILK 10 0 O14980;C9JKM9 O14980 XPO1 Exportin-1 0 50819610.0 25124100.0 13380010.0 12315500.0 False True 24326549.197737068 18722717.76883037 9089701.09291947 1.0 0.7696413336985756 0.3736535346231936 24.53602834789107 -6.962894428909502 0.39252300610962265 1.0236468162038004 0.10536229380206934 0.999862934986846 0.003028341942158896 0.0786830103982165 0.017426610034290937 0.0051061208285343 0.033274644043203606 1.0891948296262106e-07 6.962894428909502 -0.9182845224017311 down LNMILVQILK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LNMILVQILK 10 0 O14980;C9JKM9 O14980 XPO1 Exportin-1 0 129564700.0 32481600.0 54431200.0 42651900.0 False True 49276961.923041455 44717527.08709332 34221733.270008154 1.0 0.9074732966884433 0.694477336558494 25.554409976379244 -6.957204889583114 0.47318730099235934 1.0054550434262368 0.5877168293959875 0.9996520597993456 0.002386111361668887 0.08071516865484549 0.024938680485396596 0.0029629432464995473 0.017576035323297604 1.1035578652878935e-07 6.957204889583114 -0.41773821403024936 LNMILVQILK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LNMILVQILK 10 0 O14980;C9JKM9 O14980 XPO1 Exportin-1 0 73971640.0 10805400.0 19270900.0 43895340.0 False True 14800448.384955363 18419447.91765559 33528164.74490464 1.0 1.2445195874186443 2.2653479052017085 23.819137547697697 -6.9438926504924385 0.6222950042824011 0.9888429412888572 2.5753196799291813 0.9986306090528013 0.020279830476046885 0.08603477376331921 0.04685351547973202 0.02038078010842422 0.08646841139985081 1.1379085208577461e-07 6.9438926504924385 1.5864767386403242 up LNMILVQILK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LNMILVQILK 10 0 O14980;C9JKM9 O14980 XPO1 Exportin-1 0 48520500.0 25124100.0 7896000.0 15500400.0 False True 20891802.33634739 7853462.680766711 18741461.974247962 1.0 0.3759112093025751 0.8970725298143242 24.316433623325345 -10.221484613007664 7.837165236706636 1.0000002878461343 0.6364918695584726 0.3934498351789476 0.21276321815481095 1.0702020434613797e-06 1.0634420389388807e-07 0.20600726437560457 0.06866903338325656 6.005032842774502e-11 10.221484613007664 -0.36350841828766167 LNMILVQILK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LNMILVQILK 10 0 O14980;C9JKM9 O14980 XPO1 Exportin-1 0 90714900.0 32481600.0 32844000.0 25389300.0 False True 42048071.50805805 31016202.527803645 20768707.91621734 1.0 0.7376367432656152 0.4939277158581992 25.325536298471693 -6.972012263925409 0.20450164080691563 1.136896609593439 0.0879060016405862 0.9999941135225558 0.0005013421267737808 0.07565512098309655 0.006640092810472762 0.00762693277660792 0.02558554133215294 1.066566002333683e-07 6.972012263925409 -1.0489906079528528 down LNMTVQLVSNFSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNMTVQLVSNFSR 13 0 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 0 47928000.0 16017000.0 19646000.0 12265000.0 False True 20734322.242271483 18552682.829778038 10032895.849527381 1.0 0.8947812526977278 0.4838786497237471 24.305517553814 -6.9454259523426085 0.6069894500299647 1.004566249952866 0.35280547710161453 0.9987916630271926 0.007740745392164069 0.0853761460819645 0.043976491965538426 0.00789087792221627 0.034612101468052756 1.1338981524300603e-07 6.9454259523426085 -0.6517607728512516 down LNNAK(ub)YAISMAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNNAKYAISMAR 12 1 P13796;P13796-2 P13796 LCP1 Plastin-2 1 4655900.0 1286100.0 1076300.0 2293500.0 True False 1245273.4594755478 1506072.202830351 1692763.546474835 1.0 1.2094309015986253 1.3593508587164056 20.248031159254758 -6.974741379033391 0.08950230959236552 0.5569363280946872 2.0156256740987764 0.9999998383414286 5.897217354368828e-05 0.074792268837942 0.0026101243264683147 0.015638383819140077 0.026683525821033366 1.0598846952140966e-07 6.974741379033391 1.458689346004089 LNNK(ub)SVILEGDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNNKSVILEGDR 12 1 Q14181;A0A3B3ITS5;Q14181-2 Q14181 POLA2 DNA polymerase alpha subunit B 1 6641400.0 1359900.0 2769500.0 2512000.0 True False 1130817.103784765 2754580.1537972908 3037247.5858242894 1.0 2.4359201364906014 2.685887554812212 20.108934178758048 -10.372853703350518 0.3739045675885019 7.308554302212276e-21 2.721025284970759 0.9991274800716619 0.02194292737045397 1.8090656986379712 0.17521524113018194 1.8517883720413222 0.06862114124099881 4.237856986633733e-11 10.372853703350518 2.721025284970759 LNNLVLFDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNNLVLFDK 9 0 P62851 P62851 RPS25 40S ribosomal protein S25 0 14514600.0 2234700.0 6440300.0 5839600.0 False True 2929713.3408655873 5479432.344092778 5235374.209398596 1.0 1.8702964101169957 1.7869919682489475 21.482328079724752 -10.129132323432582 4.593741310827266 0.9999204711113617 1.82864418920056 0.9924771580373524 0.03400889608793086 23741413.036141478 3.476895529041661 20783.31221265822 0.011642149697943225 7.427927848799524e-11 10.129132323432582 0.8287237180891983 LNNLVLFDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNNLVLFDK 9 0 P62851 P62851 RPS25 40S ribosomal protein S25 0 12436500.0 5288000.0 1882600.0 5265900.0 False True 5120135.334504853 2634331.997629308 3886602.8163862396 1.0 0.5145043686397136 0.7590820481236551 22.287750513111682 -10.254725092978187 4.845548066224799 1.0000888966265475 0.636793208381192 0.7462215369901368 0.09984841953669892 9.591365465199733e-05 1.47521074137304e-05 0.0967013822943581 0.03222593883397981 5.562562542868762e-11 10.254725092978187 -0.3632956882453555 LNNLVLFDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNNLVLFDK 9 0 P62851 P62851 RPS25 40S ribosomal protein S25 0 18434400.0 2234700.0 10188000.0 6011700.0 False True 3060928.9804967726 9737860.4727893 4591860.274847931 1.0 3.1813415256726727 1.5001525040619192 21.545538141247643 -6.580402288207285 2.2660377013541493 2.4851145854814485 1.504415056473201 0.0 0.9475546231712413 0.698071899121329 6.743238555725747 0.35109534955765975 1.0586732457863661 2.627832695298178e-07 6.580402288207285 -0.9806995290082474 LNNLVLFDK(ub)ATYDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNNLVLFDKATYDK 14 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 15342200.0 5608900.0 4001500.0 5731800.0 True False 4664048.86640074 3979943.1252644407 6930292.879151136 1.0 0.8533236334497872 1.4858962840368486 22.153151473416763 -6.845654647419439 1.2558547589137907 0.9219295384116137 1.5091452863323664 0.9337465585742215 0.06958502821880462 0.1622990493302762 0.4947680758218782 0.04340132222834418 0.10019467683181452 1.4267416929010447e-07 6.845654647419439 0.5872157479207527 LNNMNK(ub)YDYVLTGYTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNNMNKYDYVLTGYTR 16 1 O00764;F2Z2Y4 O00764 PDXK Pyridoxal kinase 1 7826700.0 1430000.0 1968200.0 4428500.0 True False 1874743.8481396975 1674552.2319835108 3970281.3011716045 1.0 0.8932165499010245 2.117772678710909 20.83826205865871 -6.885660316880188 1.0476916848337128 0.9271967980664031 2.2145670837387303 0.9779729936412388 0.08219379728959374 0.12273577099105877 0.24297078117413815 0.060090105860700835 0.1476494133815452 1.3011869025410109e-07 6.885660316880188 1.2873702856723273 up LNNMNK(ub)YDYVLTGYTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNNMNKYDYVLTGYTR 16 1 O00764;F2Z2Y4 O00764 PDXK Pyridoxal kinase 1 13806300.0 2086000.0 2469000.0 9251300.0 True False 2019781.071818671 3454884.5756649077 6828106.996949054 1.0 1.710524285958392 3.3806173808732765 20.945767494123757 -6.956769591694008 0.47880156007845737 0.95945740205325 4.201173097122258 0.9996309651809139 0.019169032945353087 0.08087603077953914 0.02555403988226906 0.02349087418211454 0.13777453976958007 1.1046645273637175e-07 6.956769591694008 3.241715695069008 LNNMNK(ub)YDYVLTGYTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNNMNKYDYVLTGYTR 16 1 O00764;F2Z2Y4 O00764 PDXK Pyridoxal kinase 1 16785900.0 1430000.0 2225900.0 13130000.0 True False 1958709.644296942 2127552.377933029 10028964.42083825 1.0 1.0862010018318418 5.120189431873676 20.9014721201816 -6.911512787328417 0.8853596767099429 0.8809958823499278 5.658760997089351 0.9914802620147659 0.177431137184416 0.10342639752853781 0.13340020054987303 0.14636057886675222 0.4083896426082446 1.2259908041813898e-07 6.911512787328417 4.777765114739423 up LNNMNK(ub)YDYVLTGYTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNNMNKYDYVLTGYTR 16 1 O00764;F2Z2Y4 O00764 PDXK Pyridoxal kinase 1 17951000.0 2086000.0 3666000.0 12199000.0 True False 1734601.425468797 3646250.530355975 14749754.49819687 1.0 2.1020682197182743 8.5032528404677 20.726172769558033 -6.936525816447366 0.6911275093530019 0.9220360030023883 10.066235904003008 0.997672528662766 0.15959295860612335 0.08938796622375503 0.06209870578284686 0.15153087330795148 0.5598876803210797 1.1573752303780494e-07 6.936525816447366 9.14419990100062 LNNMNK(ub)YDYVLTGYTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNNMNKYDYVLTGYTR 16 1 O00764;F2Z2Y4 O00764 PDXK Pyridoxal kinase 1 71278700.0 7109700.0 13118000.0 51051000.0 True False 9203646.803139016 12387971.76835125 41760241.827494696 1.0 1.345985133211129 4.537358149516543 23.133774189442352 -6.9275483539347045 0.7666506884957371 0.946800389647466 5.153416228804362 0.9960340392801221 0.10027362006160896 0.09393101749357938 0.08406474782553676 0.09005550614344134 0.2927536848973193 1.181548752706291e-07 6.9275483539347045 4.206615839156896 up LNPDGK(ub)SIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNPDGKSIR 9 1 P25685;M0R080;P25685-2;M0QXK0;M0QYT3;M0QZD0 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 11468930.0 3689030.0 5988600.0 1791300.0 True False 4836354.054617343 5095124.223379967 1605953.459362919 1.0 1.0535052160863971 0.3320587039796415 22.205488433047563 -6.8890426312986905 1.0280500692558334 1.0396586532054353 0.27116380608787205 0.9802776683408785 0.046092504964993015 0.1199225146479807 0.22642270299634423 0.03420453877299711 0.08498218803461312 1.2910925309189456e-07 6.8890426312986905 -0.7684948471175632 down LNPDGK(ub)SIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNPDGKSIR 9 1 P25685;M0R080;P25685-2;M0QXK0;M0QYT3;M0QZD0 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 32867200.0 6333700.0 9447000.0 17086500.0 True False 6132640.160392096 13219236.36545418 12611033.065987485 1.0 2.1555538919161035 2.056379102011618 22.548076871020523 -10.426460031916514 7.148389850413328 0.9999121271556192 2.1059664969638607 0.994005284162611 0.04048793843561897 5.6705323620919627e-05 4.5496846908808795e-06 0.03920531027557295 0.013067425940285274 3.745760176483149e-11 10.426460031916514 1.1060543698082417 LNPDGK(ub)SIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNPDGKSIR 9 1 P25685;M0R080;P25685-2;M0QXK0;M0QYT3;M0QZD0 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 63958800.0 6614800.0 14852000.0 42492000.0 True False 10035135.206656527 12201544.560794367 34093437.575094834 1.0 1.2158824280415088 3.397406898163156 23.25855671894483 -6.926025870638252 0.7787240353428447 0.9614872319319616 3.8030707703135755 0.995697855046737 0.071025391673329 0.09475436453898615 0.08817934716023226 0.06323851345108145 0.2018748909834399 1.1856981148021538e-07 6.926025870638252 2.841583538381614 up LNPDGK(ub)SIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNPDGKSIR 9 1 P25685;M0R080;P25685-2;M0QXK0;M0QYT3;M0QZD0 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 20762900.0 6333700.0 12008500.0 2420700.0 True False 5266752.180485004 11943807.826999377 2926857.177947798 1.0 2.267774791313515 0.5557233523902524 22.3284821464548 -6.708333232628239 1.8012994671533042 1.780671080228156 0.5599448180964458 0.4573385016401802 0.53436481404516 0.3783171426195907 2.3918222885022016 0.23618015492291727 0.6011900222200038 1.9573422353601358e-07 6.708333232628239 -1.22072626213171 LNPDGK(ub)SIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNPDGKSIR 9 1 P25685;M0R080;P25685-2;M0QXK0;M0QYT3;M0QZD0 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 37521600.0 6614800.0 16510500.0 14396300.0 True False 8562988.997201566 15591676.161104068 11776321.118512116 1.0 1.820821697446945 1.37525823311938 23.02968304103728 -10.236794485310888 4.350810135342634 0.9997284543711882 1.5980399652966508 0.7060586080795842 0.1819005228379854 128333405.10169417 184.6829976472562 367521.986771613 0.062269387201028606 5.7970295569865097e-11 10.236794485310888 0.5983115109254626 LNPK(ub)TGLIDYNQLALTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNPKTGLIDYNQLALTAR 18 1 P34897;P34897-3;G3V2Y4;G3V5L0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 1 10197100.0 2383100.0 4699900.0 3114100.0 True False 3124267.1779732276 3998693.2400667155 2791882.8045565025 1.0 1.2798819730458344 0.8936120522085601 21.575086403039343 -6.71236212774533 1.7867072192348121 1.1716536462854674 0.8944543648478023 0.4762478368470001 0.1178990847863729 0.3704004914566376 2.3063720547444246 0.05248195637694321 0.13295219157866703 1.939268183356768e-07 6.71236212774533 -0.27719928143766515 LNPK(ub)TGLIDYNQLALTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNPKTGLIDYNQLALTAR 18 1 P34897;P34897-3;G3V2Y4;G3V5L0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 1 28815100.0 6913900.0 5424200.0 16477000.0 True False 6694422.028977522 7590111.346829324 12161179.400595527 1.0 1.133796362699381 1.8166137939846878 22.6745280734291 -6.939350184287085 0.6655873958739674 0.9922430586440101 1.9972769864474174 0.9980774699221526 0.01568024334246545 0.08806442939571239 0.05597033588911475 0.015189372072581987 0.05893902078383275 1.1498728390858788e-07 6.939350184287085 1.0050339278034073 LNPK(ub)TGLIDYNQLALTAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNPKTGLIDYNQLALTAR 18 1 P34897;P34897-3;G3V2Y4;G3V5L0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 1 164447000.0 14226000.0 19721000.0 130500000.0 True False 21581882.059910487 16201633.46912374 104706617.7998181 1.0 0.7507053103222703 4.851598090896637 24.36331734553905 -6.8924428416869405 1.0078363445778058 0.7923838551821908 5.2216456299240015 0.9824157855240464 0.24892449850205547 0.11718285996740342 0.21045706578822995 0.18756637603157392 0.47190396098539444 1.2810236813765268e-07 6.8924428416869405 4.429261774741811 up LNPK(ub)TGLIDYNQLALTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNPKTGLIDYNQLALTAR 18 1 P34897;P34897-3;G3V2Y4;G3V5L0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 1 11605300.0 2383100.0 3022800.0 6199400.0 True False 3264196.4708559755 2889242.700937134 4735229.400650776 1.0 0.8851313720645876 1.4506569818724941 21.638296464562234 -6.853808943092396 1.2164665918596405 0.9384364075724485 1.4749945240661801 0.9456778830062113 0.05688428608408349 0.15331812534248634 0.43466487143815835 0.03655066298526507 0.08481814164952216 1.4002031711814978e-07 6.853808943092396 0.5365581164937316 LNPK(ub)TGLIDYNQLALTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNPKTGLIDYNQLALTAR 18 1 P34897;P34897-3;G3V2Y4;G3V5L0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 1 23271000.0 6913900.0 6204100.0 10153000.0 True False 5749214.187703124 6170677.28188257 12275945.357832009 1.0 1.0733079479071947 2.1352388269146028 22.454933348863378 -6.920856752282769 0.8183494558142945 0.977285182139565 2.3099044134158673 0.994415602654786 0.03876497253817915 0.09767018421088386 0.10302185270143085 0.03355243336183491 0.10134327607916248 1.1998950113260785e-07 6.920856752282769 1.3326192312763023 up LNPK(ub)TGLIDYNQLALTAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNPKTGLIDYNQLALTAR 18 1 P34897;P34897-3;G3V2Y4;G3V5L0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 1 73325000.0 14226000.0 12931000.0 46168000.0 True False 18415837.436383504 12211378.482737442 37765897.72368369 1.0 0.6630911314742529 2.0507293167711707 24.134443667631498 -6.842548932362033 1.2705095611996653 0.8207925984446378 2.0987216824684176 0.9287525994586033 0.15773967225013788 0.16583799859678378 0.518894960136478 0.0973108086192046 0.22436152655508332 1.4369811382375233e-07 6.842548932362033 1.2779290840237798 up LNPTWNHPDQDTEAGFK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNPTWNHPDQDTEAGFKR 18 1 Q9HB07;F8VR84 Q9HB07 C12orf10 UPF0160 protein MYG1, mitochondrial 1 12765900.0 2647000.0 5623800.0 4495100.0 True False 3470242.633584461 4784750.961400702 4029990.172043912 1.0 1.3787943572286951 1.1612992512518585 21.726605106488357 -10.13132096571346 4.189296556043773 0.9999398712853197 1.270046804042875 0.6727215036871756 0.08879200533569806 30999288.713207103 2.2548527252575505 18534.89467331278 0.03039586513520608 7.390588710733784e-11 10.13132096571346 0.27010693275755526 LNPTWNHPDQDTEAGFK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNPTWNHPDQDTEAGFKR 18 1 Q9HB07;F8VR84 Q9HB07 C12orf10 UPF0160 protein MYG1, mitochondrial 1 14528800.0 4414700.0 3686600.0 6427500.0 True False 4274557.764984607 5158678.60536502 4743944.929133207 1.0 1.2068332887258566 1.1098095264950267 22.02734373943594 -10.091966218950734 4.0653085922706635 0.9999683422939352 1.158321407632175 0.7802329800498575 0.039609785268761355 12259634.689095119 14919577.1914676 4563.597867090796 0.014495696893392534 8.091588361315194e-11 10.091966218950734 0.1583530653382399 LNPTWNHPDQDTEAGFK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNPTWNHPDQDTEAGFKR 18 1 Q9HB07;F8VR84 Q9HB07 C12orf10 UPF0160 protein MYG1, mitochondrial 1 57242900.0 4018800.0 13135000.0 40089100.0 True False 6096813.413634775 10790956.625776585 32165471.813323278 1.0 1.7699338808112342 5.275784189391321 22.539623963876394 -6.941911691410098 0.6415316074514849 0.9615774206648529 6.276857103448444 0.9984037358599112 0.07434854213832098 0.08690521926860605 0.05071849209842243 0.0734676086690341 0.2992920560391979 1.1431107490619328e-07 6.941911691410098 5.315279682783592 LNPTWNHPDQDTEAGFK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNPTWNHPDQDTEAGFKR 18 1 Q9HB07;F8VR84 Q9HB07 C12orf10 UPF0160 protein MYG1, mitochondrial 1 16806300.0 2647000.0 6000800.0 8158500.0 True False 3625667.4324853187 5735664.814008049 6231630.329581785 1.0 1.5819610929059678 1.7187539799562184 21.78981516801125 -11.426676102859398 0.2571809156532586 6.021652875046187e-14 1.7779163927703412 0.9992996188351063 0.008247098086199951 3.7944239366291295 0.1419791425471082 2.185746207317984 0.06043801335526083 3.74389704290522e-12 11.426676102859398 1.777916392770281 LNPTWNHPDQDTEAGFK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNPTWNHPDQDTEAGFKR 18 1 Q9HB07;F8VR84 Q9HB07 C12orf10 UPF0160 protein MYG1, mitochondrial 1 13897700.0 4414700.0 4003300.0 5479700.0 True False 3671018.654370615 3981733.4283071645 6625479.93472985 1.0 1.0846399332693724 1.8048069373991695 21.807749014870215 -6.928966658379934 0.7552201424609502 0.9886189323961656 1.9488397687323653 0.9963314258784635 0.021871188073984003 0.09317746112545525 0.08033286615449547 0.019804759486004683 0.06553657426392415 1.1776963840597176e-07 6.928966658379934 0.9602208363361997 LNPTWNHPDQDTEAGFK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNPTWNHPDQDTEAGFKR 18 1 Q9HB07;F8VR84 Q9HB07 C12orf10 UPF0160 protein MYG1, mitochondrial 1 36733800.0 4018800.0 7874000.0 24841000.0 True False 5202415.8223912595 7435804.978197724 20320192.890184265 1.0 1.4292984705670644 3.90591478726593 22.310750285968844 -6.9366712123433025 0.6898331431526474 0.9699612999001245 4.513090418460229 0.9976946297390334 0.06149298914981219 0.08931852967394771 0.06177367096115369 0.0584446718469861 0.21646755285145614 1.1569878217183033e-07 6.9366712123433025 3.543129118560105 up LNPYAK(ub)TMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNPYAKTMR 9 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 17015400.0 1686700.0 10904300.0 4424400.0 True False 2211280.0340260365 9277420.944628501 3966605.529841622 1.0 4.195497992959885 1.7938051575583112 21.076450307331445 -6.573322559382954 2.29254602115941 3.1846432482315983 1.7989722638473018 0.0 1.3905383148077863 0.719658409142576 7.10428617466961 0.5113717121036779 1.5578232906101621 2.671021849280266e-07 6.573322559382954 -1.3856709843842965 LNPYAK(ub)TMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNPYAKTMR 9 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 55274900.0 16175300.0 16221600.0 22878000.0 True False 15661823.955411576 22698969.47452648 16885565.47471171 1.0 1.449318389681132 1.0781353131528015 23.900748900990923 -10.17264019844226 5.9111967543579675 0.999996607906809 1.263726851416971 0.4023023945044283 0.15153485644182363 6.774144269912e-06 9.483574918995477e-07 0.14672488254939003 0.04890766461409058 6.719853445617446e-11 10.17264019844226 0.26373024351016205 LNPYAK(ub)TMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNPYAKTMR 9 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 16095400.0 8347300.0 2414900.0 5333200.0 True False 12663464.369372321 1983942.2273001787 4279090.682375404 1.0 0.15666662529556397 0.33790837622007713 23.594168803953348 -10.42761879098581 8.827825890331638 1.0000066641915062 0.2472875018685066 0.9583289800812239 0.07399163497560977 9.704864357799952e-06 6.293316638399805e-07 0.07164272531125035 0.02388069750159958 3.7357792799766786e-11 10.42761879098581 -0.7527191623229996 LNPYAK(ub)TMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNPYAKTMR 9 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 24597600.0 1686700.0 8326500.0 14584400.0 True False 2310318.5713536064 7958607.697946608 11139865.095146475 1.0 3.4448096451407095 4.821787450991953 21.139660368854337 -8.610464838208317 0.2759874507776141 4.9518261077965235e-16 5.674385909760444 0.99900023561418 0.04997101901916288 0.22253152140567137 0.08012694904579756 0.6899529915694644 0.49068024718552217 2.4520829738094218e-09 8.610464838208317 5.674385909760443 LNPYAK(ub)TMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNPYAKTMR 9 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 69262900.0 16175300.0 38594000.0 14493600.0 True False 13450478.637289278 38386086.461690836 17524144.749165207 1.0 2.8538825640949024 1.3028640260118587 23.6811541764252 -6.602329097070244 2.1820992266492185 2.2448492732851424 1.3080070353056807 0.027375305924442928 0.8008199510923096 0.6339591076140043 5.708419968544982 0.3042678675777874 0.8903357370005244 2.4984513826647537e-07 6.602329097070244 -0.9368422379794616 LNPYAK(ub)TMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNPYAKTMR 9 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 15433600.0 8347300.0 3176900.0 3909400.0 True False 10805744.399882179 3000102.7222804576 3197929.3138314206 1.0 0.2776396156763776 0.29594715509523706 23.365295126045798 -10.100654440020925 7.793934942956196 1.00000006978696 0.28679338549648903 0.9995060577403068 0.00747402167034917 9.058629956455962e-09 1.044600821376249e-09 0.007236691065530522 0.0024122301215379707 7.931321598712079e-11 10.100654440020925 -0.713206684290471 LNQIMVGTGNGLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNQIMVGTGNGLAK 14 0 Q9NW82 Q9NW82 WDR70 WD repeat-containing protein 70 0 9429400.0 3402900.0 2831400.0 3195100.0 False True 4461234.853730474 2408966.1567107555 2864501.701563373 1.0 0.5399774357757435 0.642087178882341 22.089011667535143 -10.519593847228386 5.90159929690415 1.000597756610843 0.5910323073290629 0.9553344117676683 0.041686128062972866 0.00032831672701786056 2.6725806524062e-05 0.04041873526622892 0.013454139979646923 3.022777304268352e-11 10.519593847228386 -0.4095654492817802 LNQLKPGLQYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNQLKPGLQYK 11 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 14354500.0 2123000.0 6049500.0 6182000.0 False True 2783273.559161246 5146938.180766314 5542345.941931318 1.0 1.8492390601796869 1.9913047798296668 21.408351282898337 -10.975674041891454 0.33447446262031577 2.5289734840460208e-12 2.0204063796093745 0.9993132832808198 0.011469528237159101 2.7998401439111653 0.16779084132592267 2.2098088377298617 0.04462853783100464 1.0576109974031688e-11 10.975674041891454 2.0204063796068454 LNQLKPGLQYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNQLKPGLQYK 11 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 11170400.0 3581700.0 1304300.0 6284400.0 False True 3468000.8940234566 1825113.7918346457 4638327.112041184 1.0 0.5262725840065199 1.3374642203912337 21.725672839799447 -6.748415808605142 1.6555959442298247 0.7209047728741612 1.3388903889711357 0.6420938909181183 0.19905141124777034 0.3028563211797372 1.6327619274902994 0.09499330253311063 0.23101305286509957 1.7847779482229076e-07 6.748415808605142 0.6179856160969744 LNQLKPGLQYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNQLKPGLQYK 11 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 13530400.0 2123000.0 5187000.0 6220400.0 False True 2907930.4719177703 4957821.188884776 4751269.633159349 1.0 1.7049311311817954 1.633900699842353 21.47156134442123 -10.250114793195715 4.642617447405311 0.999779064304225 1.6694159155149335 0.9916265149655088 0.02899805217501819 6.633459598778251e-05 1.0714471459092694e-05 0.02808634960086208 0.009359081094143264 5.6219270615444586e-11 10.250114793195715 0.6696368512107085 LNQLKPGLQYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNQLKPGLQYK 11 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 6562570.0 3581700.0 2251030.0 729840.0 False True 2978342.246213609 2238903.254595531 882446.1696011159 1.0 0.7517279981647064 0.2962876985420252 21.506078115233723 -6.961698861796909 0.4107901396902953 1.022242931105217 0.008849141523187696 0.9998281094836942 0.00382057982291447 0.07909974083248979 0.018929470412427995 0.00586595077670824 0.03801618372161214 1.0921973996225901e-07 6.961698861796909 -1.0133937895820293 down LNQLVEAK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNQLVEAKK 9 1 Q9UJX2-3;Q9UJX2 Q9UJX2-3 CDC23 Cell division cycle protein 23 homolog 1 1609830.0 866210.0 743620.0 0.0 True False 1121325.920551789 702236.8933054853 0.0 1.0 0.6262558284213426 0.0 20.09677423696196 -7.588515695623482 0.6820631934380913 0.9960369780743091 7.065156406968548e-21 0.9871050981468089 0.0468489958767233 0.12109489579843544 0.1460709965609567 0.04225490490300212 0.0769794482772498 2.5791957492967772e-08 7.588515695623482 -0.9960369780743091 down LNQPELVAQK(ub)WGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNQPELVAQKWGQR 14 1 Q06546 Q06546 GABPA GA-binding protein alpha chain 1 19075200.0 5331300.0 7174700.0 6569200.0 True False 6989385.928382642 6104262.726761553 5889482.200215992 1.0 0.8733618073618225 0.8426322799403395 22.736734278573905 -13.999999999999998 0.1989054645589833 1.7010545939616821 0.8224585125921797 0.9994869096546014 0.001542697456611387 12.509497334016453 0.14142013050400631 3.410316498364487 0.019727877259594403 1.0000000000000041e-14 13.999999999999998 -0.8785960813695024 LNQPELVAQK(ub)WGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNQPELVAQKWGQR 14 1 Q06546 Q06546 GABPA GA-binding protein alpha chain 1 28977300.0 7380500.0 9168800.0 12428000.0 True False 7146210.0673814425 12829949.654660333 9172733.967991821 1.0 1.7953501973335582 1.2835802308499658 22.768746892807258 -10.230635843367 4.5185934554861795 0.9998215954493981 1.5394652140460545 0.5970258991847188 0.20892921394832575 0.00037919773546913417 6.456435809096794e-05 0.20236164830393003 0.06743161384358042 5.879821698974277e-11 10.230635843367 0.5396436185966564 LNQPELVAQK(ub)WGQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNQPELVAQKWGQR 14 1 Q06546 Q06546 GABPA GA-binding protein alpha chain 1 77768000.0 22294000.0 25124000.0 30350000.0 True False 33821627.90971768 20640425.90529204 24351309.197122473 1.0 0.6102729874620141 0.719992226930207 25.01144276573219 -10.294208661026179 8.228582980211801 1.0000005214471055 0.6651326071961119 0.9254839194898452 0.04479269194388498 4.2847348281961126e-07 3.6756576993067575e-08 0.04337040469033976 0.014456779160872138 5.0791535103526805e-11 10.294208661026179 -0.3348679142509936 LNQPELVAQK(ub)WGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNQPELVAQKWGQR 14 1 Q06546 Q06546 GABPA GA-binding protein alpha chain 1 26433800.0 5331300.0 7939500.0 13163000.0 True False 7302425.682965241 7588706.637584472 10054170.500494571 1.0 1.0392035423636086 1.3768261310688135 22.799944340096797 -6.928749452053096 0.7569759986598462 0.9946208418944708 1.4439839276143631 0.9962869911933137 0.01030743029235419 0.09329186841862185 0.0808961964512518 0.009321733951876318 0.030761625722898266 1.1782855397944007e-07 6.928749452053096 0.44936308571989236 LNQPELVAQK(ub)WGQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNQPELVAQKWGQR 14 1 Q06546 Q06546 GABPA GA-binding protein alpha chain 1 29703000.0 7380500.0 15159000.0 7163500.0 True False 6137212.761587942 15077335.45817408 8661354.729718274 1.0 2.4567073106119546 1.4112847421436363 22.549152168241534 -10.195883208279929 5.6610762482860455 0.9999738086770218 1.9339960263778322 0.5155633535461295 0.4267919763896731 0.00014109359750067 2.0042634039551387e-05 0.4132510942953212 0.1377465180709922 6.369667928177424e-11 10.195883208279929 0.9340222177008104 LNQPELVAQK(ub)WGQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNQPELVAQKWGQR 14 1 Q06546 Q06546 GABPA GA-binding protein alpha chain 1 71214000.0 22294000.0 22453000.0 26467000.0 True False 28860022.48043956 21203470.812226716 21650277.57435316 1.0 0.7347004260512195 0.7501822837812082 24.78256908782464 -10.77664731514398 10.517887206816363 1.0011525977968576 0.7424413549173529 0.9972974097993136 0.006320441951472616 0.00017145775633616722 3.640987517310143e-06 0.006142346507125766 0.0020399138682270124 1.6724482362728134e-11 10.77664731514398 -0.25871124287950475 LNQQK(ub)TAEEENPEHVEIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNQQKTAEEENPEHVEIQK 19 1 O00566 O00566 MPHOSPH10 U3 small nucleolar ribonucleoprotein protein MPP10 1 5051000.0 1787100.0 1765400.0 1498500.0 True False 2342905.4063010192 1502009.2014753039 1343449.5946269955 1.0 0.6410882818554238 0.5734117950361618 21.15986727657032 -13.999999999999998 0.23459970299042185 3.3150038789936747 0.5419146489091715 0.9995164083465322 0.004116532070932526 13.438871786796453 0.15332964629441884 14.529507746376273 0.03415205128295019 1.0000000000000041e-14 13.999999999999998 -2.773089230084503 LNQQK(ub)TAEEENPEHVEIQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNQQKTAEEENPEHVEIQK 19 1 O00566 O00566 MPHOSPH10 U3 small nucleolar ribonucleoprotein protein MPP10 1 21776000.0 4811800.0 6556200.0 10408000.0 True False 7299852.38970035 5386194.886175602 8350854.238011537 1.0 0.7378498356727318 1.143975767207853 22.799435860878422 -6.732426660922651 1.7143798391600304 0.8426684341413943 1.1438437932812673 0.5704993051851154 0.11018201236620677 0.331698218711756 1.9109827882234343 0.050908330566892174 0.125980111636457 1.8517115653478907e-07 6.732426660922651 0.30117535913987303 LNQQK(ub)TAEEENPEHVEIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNQQKTAEEENPEHVEIQK 19 1 O00566 O00566 MPHOSPH10 U3 small nucleolar ribonucleoprotein protein MPP10 1 4566600.0 1787100.0 1230100.0 1549400.0 True False 2447839.164561587 1175750.114603271 1183463.6308946507 1.0 0.480321636987065 0.48347279021765777 21.223077338093212 -10.038423647847372 5.014290619090137 1.0000078125470497 0.48189721359869825 0.9999722562502624 0.001286452932087789 3792249123.7212934 727135621.7072934 354649.26240656286 0.00044042849162261196 9.153271663603229e-11 10.038423647847372 -0.5181105989483514 LNQQQHPDCK(ub)TYHGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNQQQHPDCKTYHGK 15 1 Q5T280 Q5T280 C9orf114 Putative methyltransferase C9orf114 1 6636600.0 1999100.0 3242900.0 1394600.0 True False 2620839.459311939 2759071.9607251966 1250300.1699478182 1.0 1.0527435974462733 0.47706095293454764 21.321597552769937 -6.884502041101241 1.0543372548212766 1.0351303151352906 0.432564223724775 0.9771405078099669 0.039286334647468654 0.12371840091147948 0.24880306364952384 0.028576335512861168 0.06996928490060632 1.3046618369636638e-07 6.884502041101241 -0.6025660914105156 down LNQQQHPDCK(ub)TYHGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNQQQHPDCKTYHGK 15 1 Q5T280 Q5T280 C9orf114 Putative methyltransferase C9orf114 1 4703050.0 2661600.0 871750.0 1169700.0 True False 2213238.3288723635 867053.7097211737 1414278.8619182617 1.0 0.39175794961175026 0.6390088421425593 21.07772738303377 -10.309474090836325 5.734672384289081 1.0000531445125636 0.5153833958771696 0.8366609831127598 0.10093975419137838 6.859281327894675e-05 8.259330481492461e-06 0.0977451651828936 0.03257816557945489 4.903722765750555e-11 10.309474090836325 -0.4846697486353939 LNQQQHPDCK(ub)TYHGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNQQQHPDCKTYHGK 15 1 Q5T280 Q5T280 C9orf114 Putative methyltransferase C9orf114 1 8405070.0 2457700.0 867570.0 5079800.0 True False 3181541.0985097513 819288.9668446772 4155328.5231495467 1.0 0.25751324326076946 1.3060741302684797 21.60129432747933 -6.716487440099642 1.7718708076355538 0.546590154663708 1.3041342666452487 0.4958981098958408 0.3125841182518837 0.3622021088373167 2.2203665025705335 0.14017875167354757 0.35337438220657047 1.9209345148346218e-07 6.716487440099642 0.7575441119815407 LNQYFQK(ub)EK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNQYFQKEK 9 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 5040480.0 1431400.0 1607900.0 2001180.0 True False 1190272.5217718289 1599237.9235568377 2419617.485589113 1.0 1.3435897194167152 2.0328264673264007 20.18286049646764 -6.959986263354914 0.4356266235566836 0.9742014450198646 2.428892930340528 0.9997696913796736 0.006517269786507519 0.07970601413495776 0.021149379691213607 0.00904028979971832 0.057157200940069555 1.096512878071366e-07 6.959986263354914 1.4546914853206634 up LNQYFQKEK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNQYFQKEK 9 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 5093800.0 1544400.0 1969300.0 1580100.0 True False 2024723.3559908771 1675488.1162712763 1416606.409389467 1.0 0.8275145892468411 0.6996543034869055 20.949293371047457 -6.974409645919924 0.11010989632458894 1.2682327714500368 0.2556726300990024 0.9999996150636511 7.613549450931349e-05 0.0748958650184283 0.003254732265654254 0.010139209862593859 0.019561096030819052 1.0606945907619329e-07 6.974409645919924 -1.0125601413510343 LNSIK(ub)DVEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNSIKDVEQK 10 1 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 2328790.0 540040.0 629250.0 1159500.0 True False 522896.72580295074 880512.8064954004 855792.1657456156 1.0 1.6839134059279122 1.6366370709846705 18.996166510996332 -10.245177557154536 4.862445355944553 0.9998589275759324 1.660275238457237 0.9961697050950016 0.019300482923238965 2.9522853154991152e-05 4.582974943303198e-06 0.018691557204603425 0.006229204077490608 5.686204082870752e-11 10.245177557154536 0.6604163108813046 LNSLAIGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNSLAIGLR 9 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 60987000.0 20389000.0 18591000.0 22007000.0 False True 26730176.447356857 15817295.267150404 19729926.746050216 1.0 0.5917392763306827 0.7381143474644425 24.67196602513284 -10.121542787930709 5.602019195620774 1.0000040179591154 0.6649268118975121 0.874794805907891 0.05975737255706209 2.998837677731315e-06 4.7019097095662633e-07 0.05786052108210668 0.01928660906052522 7.558875844700264e-11 10.121542787930709 -0.3350772060616033 LNSLAIGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNSLAIGLR 9 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 33301000.0 14422000.0 5242000.0 13637000.0 False True 13964181.504203673 7335157.936668869 10065060.598769264 1.0 0.5252837722326044 0.7207769818617262 23.735227678256717 -10.205869791162957 5.448366904620504 1.0000177661615717 0.6230303770471235 0.8321525146670867 0.07980976862853013 1.722416291667097e-05 2.5106125549572444e-06 0.0772791145632109 0.02575849206355899 6.224868893005648e-11 10.205869791162957 -0.3769873891144482 LNSLAIGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNSLAIGLR 9 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 25359000.0 0.0 0.0 25359000.0 False True 0.0 0.0 20346782.53475546 0.0 LNSLAIGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNSLAIGLR 9 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 43793000.0 20389000.0 23404000.0 0.0 False True 27927364.29200725 22369933.893321652 0.0 1.0 0.8010041212418989 0.0 24.73517608665573 -7.24915179411729 0.8537398041148213 0.9893033113784195 1.0302004553416832e-16 0.9888309803870345 0.045676924925059564 0.0983065943428095 0.13819743458961958 0.03870302904314269 0.0681481286054794 5.634406882524037e-08 7.24915179411729 -0.9893033113784194 down LNSLAIGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNSLAIGLR 9 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 23737400.0 14422000.0 9315400.0 0.0 False True 11992532.002929524 9265216.091237875 0.0 1.0 0.7725821443690605 0.0 23.515632953690993 -7.295152136305265 0.8217526079119488 0.9889861655767975 2.766937170315309e-18 0.98833581204136 0.04622361577003501 0.10337998907856873 0.1375093185087947 0.039387568195823563 0.06966824478753747 5.06813137091847e-08 7.295152136305265 -0.9889861655767975 down LNSNTQVVLLSATMPSDVLEVTK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LNSNTQVVLLSATMPSDVLEVTK 23 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 26432040.0 13215600.0 5400040.0 7816400.0 False True 12796078.011853704 7556304.132836583 5769050.353026332 1.0 0.5905171979911944 0.4508452001997914 23.60919835725849 -13.999999999999998 0.1501364539993399 2.9804367911676666 0.29741909530665167 0.9995657846852105 0.004855979033855422 11.958241023281658 0.12203759750436866 6.908676444614585 0.13830781957996088 1.0000000000000041e-14 13.999999999999998 -2.683017695861015 LNSNTQVVLLSATMPSDVLEVTK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LNSNTQVVLLSATMPSDVLEVTK 23 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 177191600.0 36330400.0 100920400.0 39940800.0 False True 55115872.90801148 82910366.12531576 32046483.373325452 1.0 1.5042919897811171 0.5814383712439991 25.71596452688975 -6.758336493626857 1.6187809355893514 1.2935306175676213 0.578348960386185 0.6840986222941331 0.21205899916072415 0.2857330500317232 1.475335600363644 0.10337925193709266 0.24884159471118142 1.7444700047156606e-07 6.758336493626857 -0.7151816571814363 LNSNTQVVLLSATMPSDVLEVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNSNTQVVLLSATMPSDVLEVTK 23 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 24761700.0 9412400.0 7480400.0 7868900.0 False True 7826827.640020381 7440101.600456857 9514250.608317193 1.0 0.9505896823911001 1.2155947525493762 22.899996243966147 -6.858518573186698 1.1931709978457137 0.973289814363349 1.22807088367081 0.9518165774237451 0.02525659961626661 0.14833670127978382 0.402124586135687 0.0165191664905622 0.03849932972495103 1.385100948955772e-07 6.858518573186698 0.25478106930746103 LNSNTQVVLLSATMPSDVLEVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNSNTQVVLLSATMPSDVLEVTK 23 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 57422000.0 20316000.0 23777000.0 13329000.0 False True 26299462.488230467 22453789.048337195 10903258.767089335 1.0 0.853773686758264 0.4145810497826243 24.64852997804513 -6.951424235525683 0.5429816223144701 1.006342248731683 0.24162661665437749 0.9993083711584061 0.006542412283238837 0.08291880898634144 0.033633988652930664 0.007166803729306488 0.03638914189537653 1.1183449074764948e-07 6.951424235525683 -0.7647156320773056 down LNSNTQVVLLSATMPSDVLEVTK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 2 LNSNTQVVLLSATMPSDVLEVTKK 24 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 1 148981800.0 58619500.0 45613400.0 44748900.0 True False 56758656.05919203 63827068.49073867 33027820.651775774 1.0 1.1245345278114969 0.5818992721979177 25.75833709364359 -6.846343428403726 1.2527059517637196 1.0663004394844442 0.5617012251917489 0.9347988881096486 0.05926170625844114 0.16152637908263126 0.4896394474631614 0.03705114793593305 0.0855569645840663 1.4244807070478448e-07 6.846343428403726 -0.5045992142926953 LNSNTQVVLLSATMPSDVLEVTK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 2 LNSNTQVVLLSATMPSDVLEVTKK 24 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 1 666948600.0 83553000.0 70598000.0 512797600.0 True False 126756009.5425067 57999235.3153083 411442929.59282714 1.0 0.4575659609721201 3.245944165312752 26.917478906577195 -6.856253156818066 1.204591324748379 0.7081685164932219 3.3715718558690195 0.9489106062340743 0.2728376536057385 0.15071489700839458 0.4177220735135896 0.17690980840726603 0.4113530412725898 1.3923449474310627e-07 6.856253156818066 2.6634033393757974 up LNSNTQVVLLSATMPSDVLEVTK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LNSNTQVVLLSATMPSDVLEVTKK 24 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 1 157052200.0 58619500.0 64957600.0 33475100.0 True False 48744711.53416498 64607660.51572586 40474588.63862532 1.0 1.3254291282541 0.8303380482671814 25.538742369077866 -6.729481703253334 1.725990014067824 1.1959653609226057 0.8307080010164419 0.556489267772464 0.13680779692552325 0.3372038139199448 1.9679262582411536 0.06283099240287085 0.1559506448864077 1.8643107196658382e-07 6.729481703253334 -0.3652573599061638 LNSNTQVVLLSATMPSDVLEVTK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LNSNTQVVLLSATMPSDVLEVTKK 24 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 1 555407000.0 83553000.0 71699000.0 400155000.0 True False 108161005.5758576 67708887.62151356 327330895.93702644 1.0 0.6260009072680693 3.026329999377237 26.688605228669644 -6.8670880144097595 1.1493012490749581 0.7917578150718266 3.159390683077535 0.9616941722116306 0.20638269696820807 0.13968229293337223 0.34665072477487574 0.13958771601682954 0.32892980390459353 1.358038197768874e-07 6.8670880144097595 2.3676328680057086 up LNSNTQVVLLSATMPSDVLEVTKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNSNTQVVLLSATMPSDVLEVTKK 24 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 9198100.0 2645100.0 2691000.0 3862000.0 False True 2561132.748354535 3765530.333379612 2850426.342483456 1.0 1.4702597262085977 1.1129553297519563 21.288350601810272 -10.741233761205457 6.236169721289376 0.992902775419505 1.291607527980277 0.47036566378181943 0.1458689090286462 0.01459261255339814 0.0006055110500891438 0.14318925062891488 0.04707898794978263 1.8145387152154926e-11 10.741233761205457 0.298704752560772 LNSNTQVVLLSATMPSDVLEVTKK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LNSNTQVVLLSATMPSDVLEVTKK 24 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 207395600.0 30060200.0 123292700.0 54042700.0 False True 45603521.09498955 101290154.39473803 43361136.657243125 1.0 2.221103808711533 0.95082869954108 25.44264188487708 -6.655177060642695 1.9905197434727073 1.789120884915275 0.9562063888260355 0.21518140577358325 0.5205252293426573 0.4959272987560207 3.7722018889939504 0.211678374115054 0.5765866695829426 2.2121926209990985e-07 6.655177060642695 -0.8329144960892396 LNSNTQVVLLSATMPSDVLEVTKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNSNTQVVLLSATMPSDVLEVTKK 24 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3KTN0 P60842;J3KTN0 EIF4A1 Eukaryotic initiation factor 4A-I 0 29131800.0 8678200.0 6098100.0 14355500.0 False True 11234100.972896343 5758735.374339287 11742946.29986877 1.0 0.512612036177434 1.045294708334924 23.421381339344325 -6.666030506047581 1.9516965906923025 0.6878472157652218 1.0430986737255963 0.26154189339893663 0.20722281526206193 0.47025512127003277 3.449515753655632 0.08560016893341801 0.22987150037081125 2.1575928485306212e-07 6.666030506047581 0.3552514579603745 LNSVQSSERPLFLVHPIEGSTTVFHSLASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNSVQSSERPLFLVHPIEGSTTVFHSLASR 30 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 10456300.0 4096100.0 4235900.0 2124300.0 False True 5370026.76668882 3603920.2314088754 1904497.8137244722 1.0 0.6711177407465824 0.354653318590215 22.356497848609905 -7.280084066777095 0.2535785730158894 1.1136524607680294 9.124457069695393e-13 0.9999435149987842 0.0019801996522746516 0.10271073523748067 0.01579062746664701 0.014636739531312688 0.04586337946075201 5.2470588262484864e-08 7.280084066777095 -1.113652460767117 down LNSVQSSERPLFLVHPIEGSTTVFHSLASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNSVQSSERPLFLVHPIEGSTTVFHSLASR 30 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 24410300.0 8335300.0 6207400.0 9867600.0 False True 8070700.464012544 8686047.191163361 7282979.538345357 1.0 1.0762445254776416 0.9023974524665296 22.944262461179445 -6.7874767190553325 1.506222810244469 1.0427530039969612 0.9006702966849975 0.7931043068049327 0.03236363062037224 0.23913127498851705 1.071767809272276 0.01691442156421357 0.039677810536855186 1.6312603528074848e-07 6.7874767190553325 -0.1420827073119637 LNSVQSSERPLFLVHPIEGSTTVFHSLASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNSVQSSERPLFLVHPIEGSTTVFHSLASR 30 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 34707600.0 4096100.0 9712500.0 20899000.0 False True 5610538.8629403515 9283369.635057526 15963086.628415713 1.0 1.6546306623731915 2.845196694716385 22.419707910132797 -6.961859989261669 0.4083757317068944 0.9403027697053967 3.6035910303930074 0.9998330827184044 0.009868236836781034 0.07904326930107405 0.018724758263955654 0.015324658906146494 0.09945623492354477 1.0917922589549378e-07 6.961859989261669 2.6632882606876107 LNSVQSSERPLFLVHPIEGSTTVFHSLASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNSVQSSERPLFLVHPIEGSTTVFHSLASR 30 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 27000900.0 8335300.0 4873600.0 13792000.0 False True 6931171.266399839 4847344.949466137 16675843.432997053 1.0 0.6993543750627772 2.405919979763933 22.72466773661372 -6.861413506481916 1.178657157627718 0.8362463083680953 2.4907862646510304 0.9553309345169723 0.15720601433242806 0.1453476650563907 0.38290243136892455 0.10397128211770934 0.24308532540490255 1.3758988051874274e-07 6.861413506481916 1.654539956282935 up LNSVQSSERPLFLVHPIEGSTTVFHSLASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNSVQSSERPLFLVHPIEGSTTVFHSLASR 30 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 23251500.0 5716700.0 10824000.0 6710800.0 False True 7400380.843003895 10221634.884939313 5489503.258622788 1.0 1.3812309260546434 0.7417865884311082 22.81916808684617 -6.745204577170493 1.6674633807712431 1.225452955474439 0.7409569245236265 0.6281245145046259 0.16017267771154955 0.30849045308185036 1.6859916417677905 0.07592991189995288 0.18528428091060803 1.798023745121787e-07 6.745204577170493 -0.4844960309508126 LNVAAELVQGTVPLEVPQVK(ub)PK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNVAAELVQGTVPLEVPQVKPK 22 1 Q9NQS1 Q9NQS1 AVEN Cell death regulator Aven 1 69002000.0 26994000.0 15671000.0 26337000.0 True False 40951871.52574323 12874387.611918163 21131480.406082835 1.0 0.31437849192863004 0.5160076846011575 25.287426049636085 -10.224931791661598 5.867123087263493 1.0000165802821777 0.4151930882650189 0.9181434157254322 0.08231477321618928 1.7852846175767548e-05 2.3585557676514902e-06 0.07970319248701938 0.026566978817758716 5.957557028935268e-11 10.224931791661598 -0.5848234920171588 LNVAAELVQGTVPLEVPQVK(ub)PK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNVAAELVQGTVPLEVPQVKPK 22 1 Q9NQS1 Q9NQS1 AVEN Cell death regulator Aven 1 64582000.0 26994000.0 17483000.0 20105000.0 True False 34944265.1312903 16510055.681207862 16446096.294720596 1.0 0.4724682467688865 0.4706379210703216 25.058552371728535 LNVAAELVQGTVPLEVPQVKPK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNVAAELVQGTVPLEVPQVKPK 22 1 Q9NQS1 Q9NQS1 AVEN Cell death regulator Aven 1 35738800.0 16321000.0 11168000.0 8249800.0 True False 15802898.788663732 15627440.640350608 6088929.891305027 1.0 0.9888970909287232 0.38530461864838006 23.91368588618604 -6.910885527934155 0.8896736830913943 1.0181693985002427 0.30580230758645827 0.9912515893166742 0.026861628142766384 0.10383585595500694 0.13560945874585484 0.022088658896669326 0.06135608963367543 1.2277628042858003e-07 6.910885527934155 -0.7123670909137845 down LNVALTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNVALTR 7 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 9528000.0 2765900.0 1616400.0 5145700.0 False True 3626121.685013706 1375239.4206778507 4613272.325039794 1.0 0.37925903765489677 1.272233180730215 21.789995909028466 -6.7197554362269765 1.760058139795609 0.6222473676445883 1.2708326807044767 0.5113770465182801 0.2612188280578853 0.3558175707400598 2.1540052960025107 0.11784566062225946 0.2959371447485521 1.906534040138635e-07 6.7197554362269765 0.6485853130598884 LNVALTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNVALTR 7 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 6860400.0 2765900.0 1741900.0 2352600.0 False True 3788527.975637009 1664937.098306996 1796964.3333179045 1.0 0.43946807546724026 0.4743172928571974 21.853205970551357 -9.99575980296066 5.576977430071242 1.0000013622622537 0.45689268416175305 0.9969215148919021 0.014227133425096036 2.4098644230651205e-07 4.339505545300702e-08 0.013775397185068247 0.004591787568067056 1.009811232119837e-10 9.99575980296066 -0.5431086781005006 LNVCVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNVCVSK 7 0 B7WPG3;C9IYN3;V9GYK2;Q8WVV9-5;Q8WVV9-4;Q8WVV9;H7C464;P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0 B7WPG3;P14866;M0QYT0 HNRNPLL;HNRNPL Heterogeneous nuclear ribonucleoprotein L-like;Heterogeneous nuclear ribonucleoprotein L 0 77200000.0 24267000.0 21746000.0 31187000.0 False True 31814272.00196229 18501581.565244097 27960068.40682823 1.0 0.5815497385608235 0.878853000474242 24.92317077334869 -10.069995944521912 6.007029237311935 1.0000006990016306 0.7302013695175215 0.523365070735291 0.12137354842552374 1.136096963762187e-06 1.760796766507582e-07 0.11751973587333665 0.03917314431017346 8.511459862374639e-11 10.069995944521912 -0.2697993294841091 LNVCVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNVCVSK 7 0 B7WPG3;C9IYN3;V9GYK2;Q8WVV9-5;Q8WVV9-4;Q8WVV9;H7C464;P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0 B7WPG3;P14866;M0QYT0 HNRNPLL;HNRNPL Heterogeneous nuclear ribonucleoprotein L-like;Heterogeneous nuclear ribonucleoprotein L 0 22512200.0 11691000.0 3745900.0 7075300.0 False True 11319875.604329864 5241657.404610437 5222066.6755497735 1.0 0.4630490287901661 0.4613183799963604 23.432354768494186 LNVCVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNVCVSK 7 0 B7WPG3;C9IYN3;V9GYK2;Q8WVV9-5;Q8WVV9-4;Q8WVV9;H7C464;P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0 B7WPG3;P14866;M0QYT0 HNRNPLL;HNRNPL Heterogeneous nuclear ribonucleoprotein L-like;Heterogeneous nuclear ribonucleoprotein L 0 80786000.0 16283000.0 50164000.0 14339000.0 False True 24702501.446753994 41211842.266879104 11504890.36499304 1.0 1.6683266816403528 0.4657378682799279 24.55815380489197 -6.7558513162697755 1.627941883796954 1.3901960210318325 0.4622010472996756 0.6738580901396962 0.28095873193842086 0.2899450260944008 1.513425444948261 0.13623232667971863 0.32876177270018775 1.75448105780126e-07 6.7558513162697755 -0.9279949737321569 LNVCVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNVCVSK 7 0 B7WPG3;C9IYN3;V9GYK2;Q8WVV9-5;Q8WVV9-4;Q8WVV9;H7C464;P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0 B7WPG3;P14866;M0QYT0 HNRNPLL;HNRNPL Heterogeneous nuclear ribonucleoprotein L-like;Heterogeneous nuclear ribonucleoprotein L 0 75858000.0 24267000.0 20847000.0 30744000.0 False True 33239165.691016734 19925910.608189903 23482900.39255532 1.0 0.5994708409174996 0.7064828464964101 24.986380834871582 -10.132000805258828 7.554259055605853 1.0000000962205156 0.6529768437069575 0.9334282022172011 0.043687468336699606 7.079619368202829e-08 8.17705772012291e-09 0.04230022067218277 0.01410006977550011 7.37902861925337e-11 10.132000805258828 -0.34702325251355803 LNVCVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNVCVSK 7 0 B7WPG3;C9IYN3;V9GYK2;Q8WVV9-5;Q8WVV9-4;Q8WVV9;H7C464;P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0 B7WPG3;P14866;M0QYT0 HNRNPLL;HNRNPL Heterogeneous nuclear ribonucleoprotein L-like;Heterogeneous nuclear ribonucleoprotein L 0 23482700.0 11691000.0 3568200.0 8223500.0 False True 9721584.499115877 3548977.3983677537 9942995.828832027 1.0 0.36506162125016894 1.0227752306978648 23.212760043928462 -10.95402503580533 12.789944838900377 1.0790350859684943 0.6939184259740173 0.22406130527461354 0.2685104566718387 0.11891615549706862 0.00042745752052062287 0.051090006038196856 0.08666137724771492 1.1116676410497137e-11 10.95402503580533 -0.385116659994477 LNVCVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNVCVSK 7 0 B7WPG3;C9IYN3;V9GYK2;Q8WVV9-5;Q8WVV9-4;Q8WVV9;H7C464;P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0 B7WPG3;P14866;M0QYT0 HNRNPLL;HNRNPL Heterogeneous nuclear ribonucleoprotein L-like;Heterogeneous nuclear ribonucleoprotein L 0 52691000.0 16283000.0 24437000.0 11971000.0 False True 21078664.485915396 23077059.46815056 9792400.832832644 1.0 1.0948065274045458 0.4645645761559444 24.32928012698442 -6.868591306281862 1.1415783250016005 1.0531842332353407 0.42863823183708105 0.9632539497223614 0.053188094521324725 0.13820969949701142 0.33752125530199983 0.036190085692083436 0.08547467771008375 1.353345532740541e-07 6.868591306281862 -0.6245460013982597 down LNVCVSK(ub)QPAIMPGQSYGLEDGSCSYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNVCVSKQPAIMPGQSYGLEDGSCSYK 27 1 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 31347500.0 10667000.0 8254500.0 12426000.0 True False 13808641.778005239 7795129.818711327 10164595.501526883 1.0 0.5645109739270383 0.7361039315044955 23.719068086884864 -10.268469208551442 6.671831589972409 1.000004602944061 0.6503074527157668 0.8470359792492019 0.07005253158663516 4.796383563754843e-06 5.259120455680625e-07 0.06782896518759966 0.022609357349558903 5.389280539803167e-11 10.268469208551442 -0.3496971502282942 LNVDFALIHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNVDFALIHK 10 0 B1ALA9;P60891;A0A2R8Y7H4;P60891-2 B1ALA9 PRPS1 Ribose-phosphate pyrophosphokinase 1 0 50345900.0 9225900.0 23667700.0 17452300.0 False True 12095244.243742686 20136571.41597201 15646503.410282737 1.0 1.6648337983244446 1.2936078920752052 23.527936566698333 -10.075715209392307 4.310023110371002 0.9999533514154666 1.4792208448233801 0.6896286071306048 0.15155234183413974 19611408.096044622 11461598.551854882 8470.194201308 0.05188039827615919 8.40010646802981e-11 10.075715209392307 0.4792674934079135 LNVDFALIHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNVDFALIHK 10 0 B1ALA9;P60891;A0A2R8Y7H4;P60891-2 B1ALA9 PRPS1 Ribose-phosphate pyrophosphokinase 1 0 67434500.0 27201400.0 16845900.0 23387200.0 False True 26337906.44629358 23572555.72020798 17261390.71903913 1.0 0.8950049149986727 0.6553820347960212 24.65063733708051 -6.957383959830559 0.47085980136008876 1.0062765094399773 0.5342728994223026 0.9996605178194258 0.0026573240016246388 0.08064926099409131 0.02468748326626765 0.003318551322009105 0.01977619222094881 1.1031029351581876e-07 6.957383959830559 -0.47200361001767466 LNVDFALIHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNVDFALIHK 10 0 B1ALA9;P60891;A0A2R8Y7H4;P60891-2 B1ALA9 PRPS1 Ribose-phosphate pyrophosphokinase 1 0 313103000.0 79194000.0 135227000.0 98682000.0 False True 120143087.85692036 111094685.3166266 79177459.44614296 1.0 0.9246864492856252 0.6590263398293559 26.840178407971187 -6.947765948354962 0.5828619633349784 1.0031426807677764 0.5673655498399374 0.9990140376025528 0.004592358103489515 0.08439558853304216 0.03977325689614366 0.004796821640016398 0.02220964841063173 1.1278050934648686e-07 6.947765948354962 -0.435777130927839 LNVDFALIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNVDFALIHK 10 0 B1ALA9;P60891;A0A2R8Y7H4;P60891-2 B1ALA9 PRPS1 Ribose-phosphate pyrophosphokinase 1 0 63177100.0 9225900.0 23704200.0 30247000.0 False True 12636964.550572842 22656870.06469299 23103281.556519005 1.0 1.7929044569224448 1.8282303051543907 23.591146628221225 -11.15714579107685 0.5295694291105139 5.0338426290995225e-11 1.8257395011200728 0.9998592585310544 0.004536309360191985 3.227309650224497 0.25915553684901876 3.849586239050668 0.0068182462685673255 6.963926983732722e-12 11.15714579107685 1.8257395010697344 LNVDFALIHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNVDFALIHK 10 0 B1ALA9;P60891;A0A2R8Y7H4;P60891-2 B1ALA9 PRPS1 Ribose-phosphate pyrophosphokinase 1 0 53575800.0 27201400.0 9352100.0 17022300.0 False True 22619169.32634082 9301718.381053489 20581584.22777739 1.0 0.41123165253559113 0.9099177750886462 24.431042612514787 -10.218532736786718 7.891681103892521 1.0000002310222227 0.6605747138121258 0.3818356706004361 0.2035877570103372 8.275821799339682e-07 8.18862831385399e-08 0.19712313321337877 0.06570766603272987 6.045987754326044e-11 10.218532736786718 -0.33942551721009684 LNVDFALIHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNVDFALIHK 10 0 B1ALA9;P60891;A0A2R8Y7H4;P60891-2 B1ALA9 PRPS1 Ribose-phosphate pyrophosphokinase 1 0 265844000.0 79194000.0 114546000.0 72104000.0 False True 102518194.1471217 108171414.40597367 58981811.849516764 1.0 1.0551435801799158 0.575330187389696 26.611304730063637 -6.878293595335481 1.0892189897744886 1.033467504299339 0.5424124774940388 0.9722851042559109 0.035688546564752434 0.12915485624123677 0.28148175535623354 0.025276427663886342 0.06087117377364455 1.323446545466945e-07 6.878293595335481 -0.49105502680530033 LNVDQK(ub)VIQAGMFDQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNVDQKVIQAGMFDQK 16 1 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8Y4C5;A0A2R8YG32;A0A2R8Y7F3;A0A2R8Y6N0;A0A2R8YF80;A0A2R8YF58;A0A2R8Y526;A0A2R8Y7Y7;A0A2R8Y6V2;A0A2R8YDA1;A0A2R8Y523;A0A2R8Y5K3;P51531;P51531-2;F6VDE0;A0A0U1RQZ9 P51532;P51531 SMARCA4;SMARCA2 Transcription activator BRG1;Probable global transcription activator SNF2L2 1 8531800.0 2824200.0 4110900.0 1596700.0 True False 3702553.549591702 3497569.7441626918 1431488.8006279087 1.0 0.9446371800749203 0.3866220383998945 21.820089170516006 -6.926067480575852 0.7783953221005979 1.0098359901151193 0.282751096052076 0.9957072675668892 0.018150290919974044 0.09473183120435441 0.08806514672402911 0.01616412314174211 0.05162549184341896 1.1855845180073315e-07 6.926067480575852 -0.7270848940630432 down LNVDQK(ub)VIQAGMFDQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNVDQKVIQAGMFDQK 16 1 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8Y4C5;A0A2R8YG32;A0A2R8Y7F3;A0A2R8Y6N0;A0A2R8YF80;A0A2R8YF58;A0A2R8Y526;A0A2R8Y7Y7;A0A2R8Y6V2;A0A2R8YDA1;A0A2R8Y523;A0A2R8Y5K3;P51531;P51531-2;F6VDE0;A0A0U1RQZ9 P51532;P51531 SMARCA4;SMARCA2 Transcription activator BRG1;Probable global transcription activator SNF2L2 1 10148200.0 3631700.0 3798800.0 2717700.0 True False 3516413.6713920706 5315680.650480289 2005852.8407476167 1.0 1.5116767102022808 0.5704257314963583 21.745673368633877 -6.7590851663051 1.6160082729960679 1.2975466103879334 0.5671517267721912 0.6872038913385625 0.2151842661992609 0.28444756115026193 1.46385370857993 0.10507546191212752 0.2527319949502243 1.7414653339121077e-07 6.7590851663051 -0.7303948836157422 LNVDQK(ub)VIQAGMFDQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNVDQKVIQAGMFDQK 16 1 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8Y4C5;A0A2R8YG32;A0A2R8Y7F3;A0A2R8Y6N0;A0A2R8YF80;A0A2R8YF58;A0A2R8Y526;A0A2R8Y7Y7;A0A2R8Y6V2;A0A2R8YDA1;A0A2R8Y523;A0A2R8Y5K3;P51531;P51531-2;F6VDE0;A0A0U1RQZ9 P51532;P51531 SMARCA4;SMARCA2 Transcription activator BRG1;Probable global transcription activator SNF2L2 1 9224000.0 2824200.0 3420000.0 2979800.0 True False 3868383.061135262 3268893.091572382 2276032.6109073744 1.0 0.8450282818199121 0.5883679498481267 21.883299232038897 -6.963559094298086 0.3819760162627787 1.0172430476943426 0.4070484882225497 0.9998802905831499 0.0018572424933264021 0.07845338718129154 0.01660542105304771 0.0033337069013862825 0.02166726208406433 1.0875291478524158e-07 6.963559094298086 -0.6101945594717929 LNVDQK(ub)VIQAGMFDQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNVDQKVIQAGMFDQK 16 1 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8Y4C5;A0A2R8YG32;A0A2R8Y7F3;A0A2R8Y6N0;A0A2R8YF80;A0A2R8YF58;A0A2R8Y526;A0A2R8Y7Y7;A0A2R8Y6V2;A0A2R8YDA1;A0A2R8Y523;A0A2R8Y5K3;P51531;P51531-2;F6VDE0;A0A0U1RQZ9 P51532;P51531 SMARCA4;SMARCA2 Transcription activator BRG1;Probable global transcription activator SNF2L2 1 10663700.0 3631700.0 4568000.0 2464000.0 True False 3019919.461589177 4543391.277322995 2979211.007751213 1.0 1.5044743196337158 0.9865200200350568 21.526078644068154 -6.652221515874378 2.0009973575280964 1.3267827221088002 0.9887133468011254 0.20299456808777994 0.21519917050071963 0.5030804543111892 3.863657814902736 0.08715312099274762 0.23833353007550936 2.2272988053577235e-07 6.652221515874378 -0.3380693753076748 LNVEFALIHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNVEFALIHK 10 0 P11908;P11908-2 P11908 PRPS2 Ribose-phosphate pyrophosphokinase 2 0 7219200.0 2744300.0 2422000.0 2052900.0 False True 3597803.875839003 2060647.0408820568 1840485.6008073136 1.0 0.5727513538801546 0.5115580682891212 21.778685113593845 -13.999999999999998 0.2737252077609795 4.364621370982364 0.4919679956774726 0.9995913912672126 0.004391935000239505 15.068982941127755 0.16565533506164296 28.277008959385334 0.0249504296437772 1.0000000000000041e-14 13.999999999999998 -3.872653375304891 LNVEFALIHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNVEFALIHK 10 0 P11908;P11908-2 P11908 PRPS2 Ribose-phosphate pyrophosphokinase 2 0 17745500.0 6897800.0 5602200.0 5245500.0 False True 6678833.114664824 7839187.675087056 3871546.1883731214 1.0 1.1737361213404813 0.5796740421425269 22.671164635086416 -6.8284065065957895 1.3348947529674904 1.0929415733650918 0.5641878492047446 0.9026779428137737 0.0778015736461717 0.18278098612565188 0.6375355881466621 0.04576760744866647 0.10533966653076215 1.4845454334401232e-07 6.8284065065957895 -0.5287537241603472 LNVEFALIHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNVEFALIHK 10 0 P11908;P11908-2 P11908 PRPS2 Ribose-phosphate pyrophosphokinase 2 0 111165000.0 32466000.0 45059000.0 33640000.0 False True 49253295.58252873 37017869.4024261 26991039.255064193 1.0 0.7515815736715328 0.5480047362483198 25.55371692403949 -6.97340029299271 0.15697821513237634 1.2147813894702786 0.07941801091343152 0.9999982199360913 0.000246529124141303 0.07521398446370829 0.004831034638394139 0.009700623840086929 0.024707357175841 1.063162640250801e-07 6.97340029299271 -1.135363378556847 LNVEFALIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNVEFALIHK 10 0 P11908;P11908-2 P11908 PRPS2 Ribose-phosphate pyrophosphokinase 2 0 17392100.0 2744300.0 5301300.0 9346500.0 False True 3758941.8719189516 5067071.036945221 7139049.197209803 1.0 1.3480046272592305 1.8992177693786194 21.841895175116736 -6.964336905853925 0.3692596310570533 0.9572539174110235 2.309132960743609 0.9998988119658488 0.003724077173730037 0.0781867418485527 0.015658026711086192 0.007273681174740354 0.04683285274278408 1.0855831509807183e-07 6.964336905853925 1.3518790433325856 LNVEFALIHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNVEFALIHK 10 0 P11908;P11908-2 P11908 PRPS2 Ribose-phosphate pyrophosphokinase 2 0 13657200.0 6897800.0 3155500.0 3603900.0 False True 5735826.324352188 3138500.695182286 4357458.827449108 1.0 0.547174987125635 0.7596915563759237 22.451569910520693 -10.033821335356171 4.938809175316306 1.0000058615810907 0.6534332717470901 0.7800217124305123 0.08675952610444176 5.599674721586143e-06 1.0954690909629912e-06 0.08400597030952428 0.02800151664212294 9.25078664284145e-11 10.033821335356171 -0.34657258983400063 LNVEFALIHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNVEFALIHK 10 0 P11908;P11908-2 P11908 PRPS2 Ribose-phosphate pyrophosphokinase 2 0 94596000.0 32466000.0 36062000.0 26068000.0 False True 42027877.00053611 34055117.99895427 21323891.48026741 1.0 0.8102983169604275 0.5073749378298457 25.32484324613194 -6.964196954661518 0.3715818130089501 1.0228812728340042 0.28422150412337793 0.9998956149906975 0.00207275739505373 0.07823459540825095 0.0158276497644333 0.003983415829087035 0.025705418508764944 1.0859330360123426e-07 6.964196954661518 -0.7386597687106262 LNVGAPDVTLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNVGAPDVTLR 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9960900.0 2113500.0 4480400.0 3367000.0 False True 2770818.967163113 3811941.784462416 3018615.1385446084 1.0 1.3757455213197312 1.0894306608689055 21.40188102402375 -10.455980586605135 5.686995241935901 0.9998126077357374 1.2325880910943185 0.46805256191922084 0.11688755231345008 0.0002779404323021022 2.6587740332631304e-05 0.11326638397382238 0.037725295290744865 3.4996081027466824e-11 10.455980586605135 0.23277548335858111 LNVGAPDVTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNVGAPDVTLR 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 14843300.0 2113500.0 5523400.0 7206400.0 False True 2894918.0651899213 5279357.924558744 5504396.740466775 1.0 1.8236640228407954 1.9013998381006543 21.465091085546643 -11.103949517958474 0.4182548860340289 2.377831566255732e-09 1.9052568018132046 0.9996108150387766 0.008045733909482948 3.0167846745139597 0.20544370174148469 2.876939453877601 0.018908768809139248 7.871372805824395e-12 11.103949517958474 1.905256799435373 LNVGGTYFLTTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNVGGTYFLTTR 12 0 Q9NXV2;H3BSS5 Q9NXV2 KCTD5 BTB/POZ domain-containing protein KCTD5 0 5333580.0 1414200.0 742480.0 3176900.0 False True 1369306.9950939415 1038956.1359820507 2344774.5850429046 1.0 0.7587459493776799 1.7123804913317053 20.38501450068795 -6.839665660444993 1.28407631892038 0.8716573524805994 1.7435137150099713 0.9238563826067443 0.11171396178988012 0.16919100523509134 0.5420691134595641 0.06822523751070063 0.15715255926927876 1.446552964162617e-07 6.839665660444993 0.8718563625293719 LNVGGTYFLTTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNVGGTYFLTTR 12 0 Q9NXV2;H3BSS5 Q9NXV2 KCTD5 BTB/POZ domain-containing protein KCTD5 0 4478550.0 951550.0 1422200.0 2104800.0 False True 1303363.7496718564 1359362.501413522 1607689.5897167048 1.0 1.0429647914910662 1.2334926378928888 20.313808344413435 -6.942513674396991 0.6357491109998145 0.9979190934608633 1.2889084036596046 0.9984749463282144 0.003962599923658958 0.08663835745192486 0.04952647834793595 0.003935164107103721 0.01622546488796167 1.141527361394339e-07 6.942513674396991 0.2909893101987413 LNVIDDDVEEIK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNVIDDDVEEIKK 13 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 6888400.0 1383900.0 3071300.0 2433200.0 True False 1814306.3017066657 2613074.01183363 2181435.8049025056 1.0 1.4402606711863297 1.2023525481063984 20.79098660989241 -10.12420622569407 4.365972142178024 0.9999531344082341 1.3213066096688988 0.7086227789690553 0.09712558460776799 67769832.72123283 3.209529010692026 32851.79005230258 0.0332486709895126 7.512660689529667e-11 10.12420622569407 0.3213534752606647 LNVIDDDVEEIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNVIDDDVEEIKK 13 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 16684200.0 6558600.0 4528700.0 5596900.0 True False 6350400.832996126 6337033.526858508 4130903.986599084 1.0 0.9978950452909738 0.6504949994865314 22.59841622601607 -6.908229429734211 0.9077098307140613 1.0113677328084665 0.6072593211101167 0.9902360286784925 0.016231420169518826 0.1056004449845715 0.14520524975743257 0.013173627579021971 0.03593406208555072 1.235294677732455e-07 6.908229429734211 -0.40410841169834977 LNVIDDDVEEIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNVIDDDVEEIKK 13 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 16159700.0 6558600.0 6075500.0 3525600.0 True False 5453766.495244314 6042770.075607673 4262786.659467403 1.0 1.1079994130436224 0.7816225104585159 22.378821501450346 -6.817500326066426 1.3824704794243357 1.058361787233524 0.7748610167557903 0.878593354134235 0.04730311762901677 0.19673788412071092 0.7394762091733003 0.02689170783142911 0.06203170899714451 1.5222979899452178e-07 6.817500326066426 -0.2835007704777337 LNVIDDDVEEIK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNVIDDDVEEIKK 13 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 19041300.0 4488900.0 8303700.0 6248700.0 True False 5810969.539447624 7841591.795461052 5111500.71707638 1.0 1.3494463776188463 0.8796295837341914 22.47034746153545 -6.707585314100678 1.8043269287671706 1.2153651668260845 0.8808339520740109 0.45342629692655634 0.14731183015255636 0.37993144249572197 2.409713623288364 0.06501619996199046 0.16562532328157403 1.960715968760847e-07 6.707585314100678 -0.3345312147520736 LNVITVGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNVITVGPR 9 0 P04040 P04040 CAT Catalase 0 3767000.0 2435100.0 1331900.0 0.0 False True 3335422.2761031403 1273052.2539956886 0.0 1.0 0.38167648609789473 0.0 21.669437992525292 -8.356656464455346 0.527919405666642 1.038251852614325 3.2263670526858096e-20 0.992444103019128 0.03581653427758891 0.1678392593988584 0.1790240210158104 0.0647744071155171 0.06989392513961172 4.398894391187004e-09 8.356656464455346 -1.038251852614325 LNVK(ub)YDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNVKYDK 7 1 A6NHR9-2;A6NHR9;J3KTL8;A6NHR9-3;A0A2R8YE92 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 1 26484400.0 10854000.0 10567000.0 5063400.0 True False 14229699.11028551 8990444.789843392 4539487.939562441 1.0 0.631808495749915 0.3190150335843158 23.762401820335356 -7.605032619631203 0.24981767797147805 1.1413157074933178 1.893645004761132e-13 0.9998212807784944 0.0037207071891437083 0.12958995633406256 0.028927231820798368 0.033622811060142074 0.07315396632012441 2.482946605471876e-08 7.605032619631203 -1.1413157074931284 down LNVK(ub)YDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNVKYDK 7 1 A6NHR9-2;A6NHR9;J3KTL8;A6NHR9-3;A0A2R8YE92 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 1 28071900.0 8963300.0 12476000.0 6632600.0 True False 8678764.94776237 17457731.861480508 4895323.086265098 1.0 2.0115456480915066 0.5640575722156469 23.049058320460016 -6.718868696864388 1.7638570931898578 1.6161699347249276 0.5665262004057771 0.5069796984186912 0.42572210376811165 0.35750954873622937 2.173242857276196 0.19170787500860786 0.4818143915529421 1.9104307644847288e-07 6.718868696864388 -1.0496437343191505 LNVK(ub)YDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNVKYDK 7 1 A6NHR9-2;A6NHR9;J3KTL8;A6NHR9-3;A0A2R8YE92 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 1 36663000.0 12198000.0 13564000.0 10901000.0 True False 18505257.79325094 11143398.223984294 8746412.571921973 1.0 0.602174708857523 0.472644729927074 24.14143189790177 -13.999999999999998 0.15690799305816036 2.946978120587675 0.3408640602800687 0.9995448447774039 0.004787155533059742 11.99045252579398 0.12506637064305523 7.107185525452667 0.11965709872538273 1.0000000000000041e-14 13.999999999999998 -2.6061140603076063 LNVK(ub)YDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNVKYDK 7 1 A6NHR9-2;A6NHR9;J3KTL8;A6NHR9-3;A0A2R8YE92 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 1 24521300.0 10854000.0 7009100.0 6658200.0 True False 14867017.118320988 6699414.786005845 5085670.28993337 1.0 0.4506226590504152 0.3420773817275138 23.825611881858247 -13.999999999999998 0.22798298143148987 4.435996832124445 0.28827859649044324 0.9995071064987933 0.006393789008042463 13.229255128950404 0.15119833199666083 20.55317493818844 0.057060260646860365 1.0000000000000041e-14 13.999999999999998 -4.147718235634002 LNVK(ub)YDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNVKYDK 7 1 A6NHR9-2;A6NHR9;J3KTL8;A6NHR9-3;A0A2R8YE92 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 1 29432400.0 8963300.0 15668000.0 4801100.0 True False 7453381.091517008 15583593.374145484 5804987.812221743 1.0 2.090808611930738 0.7788395281208192 22.829463595894293 -6.68601174303357 1.8801734622440018 1.6864292460671124 0.7835431436114246 0.35180742096122597 0.46172079503215613 0.42541563237601443 2.9123948094061016 0.1966667364230657 0.5148017573062998 2.0605741959627137e-07 6.68601174303357 -0.9028861024556878 LNVK(ub)YDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNVKYDK 7 1 A6NHR9-2;A6NHR9;J3KTL8;A6NHR9-3;A0A2R8YE92 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 1 33835000.0 12198000.0 13500000.0 8137000.0 True False 15790551.458527045 12748713.132546265 6656149.492670563 1.0 0.8073633885447262 0.4215273614827543 23.91255821999422 -6.960016289554684 0.43520450275125644 1.0145063056938384 0.1994604085726958 0.9997708016992607 0.00364115938029827 0.07969530804561474 0.021109846731185895 0.00505838596192754 0.03199952498067003 1.0964370701162253e-07 6.960016289554684 -0.8150458971211425 down LNVLANVIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNVLANVIR 9 0 E9PDF2;E9PCR7;Q02218-2;Q02218;E9PFG7;A0A0D9SFS3;Q02218-3;Q9ULD0-3;Q9ULD0-2;Q9ULD0 E9PDF2 OGDH;OGDHL 2-oxoglutarate dehydrogenase, mitochondrial;2-oxoglutarate dehydrogenase-like, mitochondrial 0 6888100.0 2518900.0 2630900.0 1738300.0 False True 3302302.2930622967 2238379.97516788 1558437.3909510195 1.0 0.6778240683387533 0.4719245098260967 21.655040760059954 -8.67923894986993 0.12646836597060274 1.5084573297239798 8.178835606553167e-11 0.9999374246219945 0.0017190992480586125 0.24568057678145314 0.034419945141040534 0.21236909143971397 0.16922290174049928 2.0929605870436227e-09 8.67923894986993 -1.5084573296421915 LNVLANVIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNVLANVIR 9 0 E9PDF2;E9PCR7;Q02218-2;Q02218;E9PFG7;A0A0D9SFS3;Q02218-3;Q9ULD0-3;Q9ULD0-2;Q9ULD0 E9PDF2 OGDH;OGDHL 2-oxoglutarate dehydrogenase, mitochondrial;2-oxoglutarate dehydrogenase-like, mitochondrial 0 9116300.0 2518900.0 2677100.0 3920300.0 False True 3450205.400712984 2558816.8700141604 2994405.881112886 1.0 0.7416418945623879 0.8678920624534681 21.718250821582846 -10.112815297107696 4.721398892898764 1.0000126415497173 0.8047669785054702 0.7612489237103144 0.05154141522074371 6.858955141657924e-06 1.288785281785087e-06 0.04990799138078356 0.0166349202312966 7.712313995103878e-11 10.112815297107696 -0.19524566304424706 LNVLANVIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNVLANVIR 9 0 E9PDF2;E9PCR7;Q02218-2;Q02218;E9PFG7;A0A0D9SFS3;Q02218-3;Q9ULD0-3;Q9ULD0-2;Q9ULD0 E9PDF2 OGDH;OGDHL 2-oxoglutarate dehydrogenase, mitochondrial;2-oxoglutarate dehydrogenase-like, mitochondrial 0 4793100.0 2243500.0 1232400.0 1317200.0 False True 1865569.653901844 1225760.8165877531 1592620.4299553179 1.0 0.6570437153199137 0.8536912179206753 20.831184795714613 -10.188684872224071 5.312838380234039 1.0000119709347477 0.7553674666202274 0.6735687942909077 0.08028100676098411 1.1383923386390405e-05 1.7384260321353848e-06 0.0777355528307437 0.025910583516804093 6.476123583477408e-11 10.188684872224071 -0.24464450431452034 LNVLEK(ub)SSPGHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNVLEKSSPGHR 12 1 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PK06;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;P29692-3;E9PL71;E9PN91 E9PI39;P29692;P29692-3 EEF1D Elongation factor 1-delta 1 9355700.0 2896700.0 5160100.0 1298900.0 True False 3797601.7516826987 4390233.193912261 1164502.2879285966 1.0 1.1560541312598063 0.30664149746945196 21.856657189662172 -6.859298642759133 1.189332999174557 1.0845145335007538 0.26606995361469965 0.9527695007570403 0.08023089211009347 0.14753394005035975 0.39695657059418893 0.05262973433088087 0.12275339487097488 1.3826152960895735e-07 6.859298642759133 -0.8184445798860541 down LNVLEK(ub)SSPGHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNVLEKSSPGHR 12 1 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PK06;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;P29692-3;E9PL71;E9PN91 E9PI39;P29692;P29692-3 EEF1D Elongation factor 1-delta 1 13306800.0 5253200.0 4892200.0 3161400.0 True False 5086440.041456303 6845680.972485963 2333334.5000329367 1.0 1.3458688034639588 0.45873626367664366 22.278224848136485 -6.800997855232271 1.4521007614443875 1.190589804291009 0.44622278800788695 0.8349908552654449 0.14830309710433742 0.2193381518000759 0.9130158787293544 0.08034604313713056 0.1867206139866253 1.581255848299236e-07 6.800997855232271 -0.7443670162831221 down LNVLEK(ub)SSPGHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNVLEKSSPGHR 12 1 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PK06;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;P29692-3;E9PL71;E9PN91 E9PI39;P29692;P29692-3 EEF1D Elongation factor 1-delta 1 13629800.0 5253200.0 6858200.0 1518400.0 True False 4368268.5562189305 6821253.515353878 1835890.4197116252 1.0 1.561546280308872 0.42027874341607063 22.05863012357076 -6.772919607326552 1.563368335066099 1.3208834830036456 0.4131518468786581 0.7415828288723967 0.23685953870350512 0.26172793742168626 1.2628580566536844 0.11939477432422407 0.28344428296773927 1.68686525375526e-07 6.772919607326552 -0.9077316361249874 down LNVTEQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNVTEQEK 8 0 P06733;A0A2R8Y6G6;K7EM90;A0A2R8YEM5;A0A2R8Y879;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 0 29520600.0 8186700.0 4365900.0 16968000.0 False True 7926817.68967302 6109226.637867728 12523571.770911256 1.0 0.7707035631495308 1.5798990542228368 22.918310365293895 -6.830998316540587 1.323360555848968 0.877559206649745 1.6021339626403839 0.9078703595417759 0.10336115442722214 0.1795834716771037 0.6147172962411058 0.06131717385274663 0.14111131181371417 1.475712253580833e-07 6.830998316540587 0.7245747559906389 LNVTPLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNVTPLAR 8 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 9249980.0 427980.0 4518300.0 4303700.0 False True 561085.9245642152 3844187.252195459 3858394.4080054746 1.0 6.851334321354017 6.876655141549338 19.097862196162808 -10.290294029626782 1.0829640848624942 6.906232265670743e-14 6.8694071732052056 0.9999966931153976 0.005026892346024537 1.7392338081130398 0.6709950482960454 5.431971651708502 0.0032573304589824698 5.125142798663962e-11 10.290294029626782 6.869407173205136 LNVTPLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNVTPLAR 8 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 8100600.0 4171200.0 1002600.0 2926800.0 False True 4038787.539199446 1402943.4084899297 2160183.27788208 1.0 0.34736746978476024 0.5348593499697347 21.945490824252186 -10.379408659863811 5.064877493680819 1.0004018875735188 0.4411134098772269 0.9221629306253353 0.07654323956157409 0.0003476037193908284 4.25914175927211e-05 0.07416431404991874 0.024704224340532675 4.17437384011259e-11 10.379408659863811 -0.5592884776962919 LNVTPLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNVTPLAR 8 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 10057280.0 427980.0 5117600.0 4511700.0 False True 586215.7717246191 4891487.510359884 3446129.381378211 1.0 8.344175892725232 5.878602295601603 19.1610722576857 -9.326182998085544 8.822114223376994 0.9999999927230666 7.111389094164782 0.8912081226363116 1.00656620604354 0.0 0.0 0.9746034873836826 0.3248678460710716 4.718641705925312e-10 9.326182998085544 6.111389101441715 LNVWDLSK(ub)IGEEQSAEDAEDGPPELLFIHGGHTAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAK 35 1 Q16576;E9PC52;Q16576-2;Q5JNZ6 Q16576 RBBP7 Histone-binding protein RBBP7 1 16578000.0 5034000.0 4503300.0 7040700.0 True False 4185994.044012429 4479039.829064935 8512877.817481332 1.0 1.0700062594383462 2.0336574127853813 21.997138828199247 -6.921509310524279 0.8134542090139484 0.9798724216517872 2.1945809872057835 0.9945900377854688 0.03469004491831333 0.09729174118848927 0.10107190057761076 0.030130447822535544 0.09159943269552331 1.1980934378588184e-07 6.921509310524279 1.2147085655539964 up LNVWLGIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNVWLGIK 8 0 F6TDL0;Q92569;Q92569-3;Q92569-2 F6TDL0 PIK3R3 Phosphatidylinositol 3-kinase regulatory subunit gamma 0 13586300.0 1860100.0 3963000.0 7763200.0 False True 2407936.118052646 3742455.5662430194 6350377.257158673 1.0 1.5542171315033184 2.6372698218814756 21.19936568758825 -6.960495349234059 0.4283951454982065 0.9562400037573114 3.276670449939257 0.9997881327906404 0.009896909594036267 0.07952463950820157 0.020480968610103806 0.014101594704133571 0.08996090445764388 1.0952282838674166e-07 6.960495349234059 2.3204304461819456 LNWLSVDFNNWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNWLSVDFNNWK 12 0 Q15185-4;Q15185;A0A087WYT3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 126792000.0 49187000.0 54143000.0 23462000.0 False True 64484633.3275855 46065075.44776098 21034377.303395774 1.0 0.7143574068840222 0.3261920897733879 25.942452071827095 -7.017215316105162 0.33327363057357584 1.0470865450827054 2.8466479050360717e-15 0.9999438716535941 0.0020688032925776597 0.07302771134573427 0.013011995662695338 0.00566255123884941 0.032116368862138873 9.61135644897839e-08 7.017215316105162 -1.0470865450827025 down LNWLSVDFNNWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNWLSVDFNNWK 12 0 Q15185-4;Q15185;A0A087WYT3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 483713600.0 231023600.0 116970000.0 135720000.0 False True 223689882.27392542 163676730.99049163 100170860.48727474 1.0 0.7317127146146776 0.44781131568842186 27.73692476237415 -6.970408992657559 0.24822438906276229 1.0920880226631609 0.07913964227779224 0.9999853982810943 0.0008615132967767022 0.07617021733231989 0.00855402462285506 0.006409012854886037 0.027288905916403407 1.0705106872250069e-07 6.970408992657559 -1.0129483803853687 down LNWLSVDFNNWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNWLSVDFNNWK 12 0 Q15185-4;Q15185;A0A087WYT3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 1017880000.0 304470000.0 367580000.0 345830000.0 False True 461903249.73857373 301982477.0843514 277476548.9173262 1.0 0.6537786370961155 0.6007243921197163 28.783015455459548 -13.999999999999998 0.26407738853532237 3.589306425220917 0.5820775809859918 0.9995707601940392 0.0036680360156758174 14.601369679938946 0.16263591264773128 20.225298061617416 0.02270711726948929 1.0000000000000041e-14 13.999999999999998 -3.007228844234925 LNWLSVDFNNWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNWLSVDFNNWK 12 0 Q15185-4;Q15185;A0A087WYT3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 323526000.0 49187000.0 78989000.0 195350000.0 False True 67372763.12869486 75499004.79830733 149212353.35953936 1.0 1.1206161257493594 2.2147281249919235 26.005662133349986 -6.927835972727859 0.7643416496378409 0.9819589930962336 2.42745075606962 0.9960957570756672 0.03414260424994652 0.09377669457654822 0.0832981312185222 0.030714419148663494 0.1002016898294667 1.1807665113139102e-07 6.927835972727859 1.4454917629733866 up LNWLSVDFNNWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNWLSVDFNNWK 12 0 Q15185-4;Q15185;A0A087WYT3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 465478010.0 231023600.0 99428110.0 135026300.0 False True 192106359.48079273 98892471.03649548 163259675.03892773 1.0 0.5147797881536712 0.8498400338238196 27.517330037808428 -10.119867945815136 5.650467188158241 1.000003379452705 0.6823099109887083 0.5451799439825947 0.13678777249737642 5.8234081216167155e-06 9.070889131815141e-07 0.1324456000911096 0.04414806373724246 7.588082677473718e-11 10.119867945815136 -0.3176934684639967 LNWLSVDFNNWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNWLSVDFNNWK 12 0 Q15185-4;Q15185;A0A087WYT3;B4DDC6 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 847120000.0 304470000.0 331850000.0 210800000.0 False True 394142417.0009622 313382255.78040546 172436562.99065444 1.0 0.7950990359396929 0.4374981112226586 28.554141777551997 -6.9626197343180065 0.3967956500956245 1.0203661834373048 0.19924106219988097 0.9998553507905465 0.0027956006091472262 0.07877831414307683 0.017768783758939574 0.0046041275829295574 0.02999767847400611 1.0898839716325391e-07 6.9626197343180065 -0.8211251212374238 down LNWTGTSK(ub)SGVQYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNWTGTSKSGVQYK 14 1 O95433;O95433-2;H0YJU2;H0YJG7 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 1 14604500.0 5030200.0 3424200.0 6150100.0 True False 4870519.054392274 4791500.9169670995 4539204.310954823 1.0 0.9837762389300346 0.9319754753574636 22.215644098776398 -6.950041902112415 0.5583835430617673 1.0006833026077282 0.9125996302742433 0.9992045273430891 0.0008181621095364541 0.08346892235878507 0.035892787068627474 0.0008787451588570729 0.004304550078641075 1.1219102036164037e-07 6.950041902112415 -0.08808367233348491 LNWTGTSK(ub)SGVQYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNWTGTSKSGVQYK 14 1 O95433;O95433-2;H0YJU2;H0YJG7 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 1 12229100.0 5030200.0 4292400.0 2906500.0 True False 4182834.1756438864 4269275.989225304 3514235.7118623815 1.0 1.0206658475931838 0.8401565934230266 21.996049374210674 -6.878412846047025 1.0885662451899965 1.0125596156002392 0.8277447481949597 0.9723845432950261 0.013404712874026059 0.12904750362239178 0.280834773886355 0.009498670259208754 0.022881289137841293 1.3230831969026993e-07 6.878412846047025 -0.18481486740527953 LNWTGTSK(ub)SGVQYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNWTGTSKSGVQYK 14 1 O95433;O95433-2;H0YJU2;H0YJG7 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 1 31641900.0 7927900.0 9734000.0 13980000.0 True False 10262822.832272239 9192294.343126316 11435783.446913397 1.0 0.8956886904663731 1.1142922014548173 23.290924269034857 -6.776976679274685 1.547910796890347 0.9407034734069891 1.115854483895754 0.7564489888634113 0.04405825679532626 0.25530550405342256 1.2080781165671846 0.022424246937666443 0.05304136838579513 1.6711803508677407e-07 6.776976679274685 0.1751510104887649 LNYEHDNISLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNYEHDNISLKR 12 1 Q969X6;H3BSH7;Q969X6-3;A0A0J9YWM9;A0A0J9YWK2;H3BRM8 Q969X6 CIRH1A Cirhin 1 8801040.0 2800770.0 3820270.0 2180000.0 True False 3671836.592695262 3250300.6072958233 1954434.5120366022 1.0 0.885197509541127 0.5322770942271089 21.808070425419626 -6.950900460140858 0.5488693478607203 1.0049138122452312 0.3960132367830461 0.9992700635725237 0.005377111521128644 0.08312617620235896 0.034481497538567 0.005844703827573905 0.029271541730913248 1.1196944869114274e-07 6.950900460140858 -0.6089005754621851 LNYEHDNISLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LNYEHDNISLKR 12 1 Q969X6;H3BSH7;Q969X6-3;A0A0J9YWM9;A0A0J9YWK2;H3BRM8 Q969X6 CIRH1A Cirhin 1 12291140.0 3143990.0 2719550.0 6427600.0 True False 3044185.7583831158 3805480.4972658986 4744018.73613327 1.0 1.2500815650905404 1.558386745312481 21.537624965130615 -6.968311835693409 0.2957431044572347 0.9437511189892642 1.8743195962919164 0.9999660564816204 0.001330513753037539 0.07685436661849207 0.01098050477438356 0.005226031775386529 0.027777886170571208 1.0756925586567958e-07 6.968311835693409 0.9305684773026521 LNYEHDNISLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNYEHDNISLKR 12 1 Q969X6;H3BSH7;Q969X6-3;A0A0J9YWM9;A0A0J9YWK2;H3BRM8 Q969X6 CIRH1A Cirhin 1 40006500.0 6618400.0 3389500.0 29998600.0 True False 10040596.66985178 2784617.2427156237 24069363.56114656 1.0 0.277335833145933 2.3972045041325094 23.25934166926302 -6.814725187307925 1.3947360851583912 0.6083012852125413 2.438378428498212 0.8717705949117223 0.3150902419803033 0.200428870839012 0.7675175329479564 0.17759811229496564 0.4099827506411948 1.532056609202114e-07 6.814725187307925 1.8300771432856708 LNYEHDNISLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNYEHDNISLKR 12 1 Q969X6;H3BSH7;Q969X6-3;A0A0J9YWM9;A0A0J9YWK2;H3BRM8 Q969X6 CIRH1A Cirhin 1 8060070.0 2800770.0 2150000.0 3109300.0 True False 3836290.356963322 2055005.8909007637 2374947.3780435934 1.0 0.535675274727494 0.6190739378558201 21.871280486942517 -10.818019336353897 7.281988965021033 1.0199882330239807 0.577374606291657 0.9716230264266107 0.03404736164911074 0.010403238380589099 0.00025998201720224166 0.031040443134308433 0.010988738720775567 1.520479830989248e-11 10.818019336353897 -0.44261362673232363 LNYEHDNISLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNYEHDNISLKR 12 1 Q969X6;H3BSH7;Q969X6-3;A0A0J9YWM9;A0A0J9YWK2;H3BRM8 Q969X6 CIRH1A Cirhin 1 15684390.0 3143990.0 5944600.0 6595800.0 True False 2614366.9873727905 5912575.259889279 7974951.284466497 1.0 2.261570501940471 3.0504329816682025 21.31803024056489 -8.51252715101726 0.19263470650269887 3.0756560408191696e-18 4.031039242500605 0.9997330471476958 0.013797505253301463 0.1656623258500884 0.050074603170935345 0.4800400541298603 0.3998336452587473 3.0723652825818866e-09 8.51252715101726 4.031039242500605 LNYEHDNISLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LNYEHDNISLKR 12 1 Q969X6;H3BSH7;Q969X6-3;A0A0J9YWM9;A0A0J9YWK2;H3BRM8 Q969X6 CIRH1A Cirhin 1 62746100.0 6618400.0 11119700.0 45008000.0 True False 8567649.268168174 10500878.919998119 36817005.82107863 1.0 1.2256429495792471 4.297212067009645 23.03046799135547 -6.9216557936692364 0.8123533134085192 0.936185429719253 4.811896048452824 0.9946285212530823 0.11022578316184375 0.09720765503468438 0.100638367279765 0.09581264225374649 0.2917084380441765 1.1976894011784154e-07 6.9216557936692364 3.875710618733571 up LNYKPPPQK(ub)SLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LNYKPPPQKSLK 12 2 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 5383300.0 1651800.0 2093100.0 1638400.0 True False 2165525.796053954 1780817.6388398975 1468874.0846425535 1.0 0.8223488457560394 0.6782990474272589 21.046285927422314 -6.973511162367432 0.15254474060049072 1.1616081307319872 0.3352428284637663 0.9999984307959517 0.00016471685611548035 0.07517903968463024 0.004674146333431502 0.007168245177724031 0.017786761358948504 1.062891264173565e-07 6.973511162367432 -0.8263653022682209 LNYKPPPQK(ub)SLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LNYKPPPQKSLK 12 2 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 13721900.0 2942800.0 3888100.0 6891000.0 True False 4464442.7474978585 3194238.1771360436 5528990.829567402 1.0 0.7154841842078244 1.2384503827865594 22.090048678468303 -6.758930444205706 1.616230164519605 0.8345240752066917 1.2402802452810064 0.6867326110037302 0.11965103905293088 0.2846952671824795 1.4654342191625216 0.058414982795863206 0.14054395980665504 1.742085860272525e-07 6.758930444205706 0.40575617007431475 LNYKPPPQK(ub)SLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LNYKPPPQKSLK 12 2 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 5190000.0 1651800.0 2054200.0 1484000.0 True False 2262515.098216567 1963438.6516690021 1133509.763939373 1.0 0.8678123974583362 0.5009954474261253 21.109495988945206 -6.953189602263366 0.5226603990237754 1.006107488724137 0.3462561378184257 0.9994283781637792 0.0050468842557309 0.08222977615882203 0.030853827949602643 0.005693562018843133 0.03030751559796513 1.1138081662467653e-07 6.953189602263366 -0.6598513509057113 LNYKPPPQK(ub)SLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LNYKPPPQKSLK 12 2 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 10969900.0 3115800.0 5764100.0 2090000.0 True False 2590925.753344048 5733047.64921573 2527009.336931835 1.0 2.212741002638234 0.9753306645975025 21.305036242959858 -6.650807303986659 2.006040534085456 1.7864581996055644 0.9805701426238145 0.1972247706247242 0.5175111000182087 0.5065222109146897 3.908113148140712 0.209174431054502 0.5730979946045229 2.2345634764131366e-07 6.650807303986659 -0.8058880569817499 LPAAGVGDMVMATVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPAAGVGDMVMATVK 15 0 P62829;C9JD32;J3KT29;B9ZVP7 P62829 RPL23 60S ribosomal protein L23 0 22506700.0 2573500.0 9895200.0 10038000.0 False True 3373883.421809453 8418874.731187496 8999364.051295146 1.0 2.495306944148164 2.6673607016536103 21.685978694199495 -10.492016269281065 0.4386206574809004 1.5380133088667967e-16 2.6730673138329104 0.9994106960542088 0.01817633849543935 1.9296023807106375 0.20722597496462203 2.2151607829845554 0.039721325180048096 3.220948127784088e-11 10.492016269281065 2.6730673138329104 LPAAGVGDMVMATVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPAAGVGDMVMATVK 15 0 P62829;C9JD32;J3KT29;B9ZVP7 P62829 RPL23 60S ribosomal protein L23 0 13822200.0 5051700.0 2256200.0 6514300.0 False True 4891336.548660771 3157112.4259275678 4808009.405189021 1.0 0.645449846789212 0.9829643405963212 22.22179730212088 -10.617515407883522 9.20862620612086 1.0000558304963572 0.8142070940692561 0.28776381000989526 0.13778971510352842 0.0001579847163067772 6.561950545345516e-06 0.13345422173420987 0.044471439322885845 2.412595937084089e-11 10.617515407883522 -0.1858487364271011 LPAAGVGDMVMATVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPAAGVGDMVMATVK 15 0 P62829;C9JD32;J3KT29;B9ZVP7 P62829 RPL23 60S ribosomal protein L23 0 14269600.0 2573500.0 4292900.0 7403200.0 False True 3524992.4962225086 4103225.4832780897 5654716.633690004 1.0 1.1640380760172493 1.6041783464077652 21.749188755722386 -6.953929614254674 0.5138990352273949 0.9921523487328895 1.7955024072596513 0.9994746578748334 0.005846873495446065 0.08194519263819161 0.02972150584950057 0.00669000118267827 0.0363361221976905 1.1119119193190037e-07 6.953929614254674 0.8033500585267618 LPAELGPQLLHKIIDGICGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPAELGPQLLHKIIDGICGR 20 1 Q9NX08 Q9NX08 COMMD8 COMM domain-containing protein 8 0 22233600.0 7045500.0 7294900.0 7893200.0 False True 9236718.728719048 6206529.355297492 7076487.380920791 1.0 0.6719409281133557 0.7661256760930037 23.138949005971902 -10.210349401530834 7.699828111029763 1.0000002336043747 0.7190333021031801 0.9222729459641356 0.03845076235046109 1.5414525045316272e-07 1.5850868737823006e-08 0.037229821069643995 0.01240993018602624 6.160991341807965e-11 10.210349401530834 -0.28096693150119467 LPAELGPQLLHKIIDGICGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPAELGPQLLHKIIDGICGR 20 1 Q9NX08 Q9NX08 COMMD8 COMM domain-containing protein 8 0 28989900.0 7045500.0 8738400.0 13206000.0 False True 9650411.747478396 8352308.593975462 10087014.786107382 1.0 0.8654872779037515 1.0452419078121788 23.202159067494794 -6.706419892902577 1.8077209505347673 0.9170013254418466 1.0447797247036787 0.44805741549113354 0.056716271460295946 0.3823911583699323 2.433523573764734 0.024987379900023636 0.06376265360760801 1.965984579694545e-07 6.706419892902577 0.1277783992618321 LPAHYQFLLDLGVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPAHYQFLLDLGVR 14 0 Q9BVJ7 Q9BVJ7 DUSP23 Dual specificity protein phosphatase 23 0 36368500.0 9374500.0 10336000.0 16658000.0 False True 14221801.86775136 8491460.04446341 13365538.99853922 1.0 0.5970734315824083 0.9397922374974329 23.761600926706432 -10.092192214378308 7.269295163186172 1.0000000582846555 0.7684328345399206 0.3783873814569877 0.1399143666246253 1.3221606561563333e-07 1.6384303729144133e-08 0.13547153727556518 0.04515716765269435 8.087378806885279e-11 10.092192214378308 -0.23156722374473493 LPAHYQFLLDLGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPAHYQFLLDLGVR 14 0 Q9BVJ7 Q9BVJ7 DUSP23 Dual specificity protein phosphatase 23 0 25533900.0 9374500.0 8195500.0 7963900.0 False True 12135475.049021307 7739413.220576509 6514551.916514563 1.0 0.6377511543069483 0.536818862895684 23.53272724879888 -13.999999999999995 0.17927910629098745 2.87541933801688 0.45604356350509156 0.9994990245571892 0.004451230380366275 12.195541898926603 0.13421888798859224 7.965822207933931 0.07582418946532868 1.0000000000000123e-14 13.999999999999995 -2.4193757745117885 LPALTVHVTQPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPALTVHVTQPK 12 0 C9JIZ6;P07602;P07602-2;P07602-3;Q5BJH1 C9JIZ6 PSAP Prosaposin;Saposin-A;Saposin-B-Val;Saposin-B;Saposin-C;Saposin-D 0 19874400.0 7539000.0 6155200.0 6180200.0 False True 9883702.00777986 5236868.152781684 5540732.188664505 1.0 0.5298488510337052 0.5605928005825318 23.236620083594772 -10.018315329240064 6.194452132235634 1.0000003773999417 0.5452208258081022 0.9965841913879118 0.012551164845474107 6.540702406977432e-08 1.0378054876971315e-08 0.012152623246055469 0.004050871035160195 9.587042900173629e-11 10.018315329240064 -0.4547795515918396 LPALTVHVTQPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPALTVHVTQPK 12 0 C9JIZ6;P07602;P07602-2;P07602-3;Q5BJH1 C9JIZ6 PSAP Prosaposin;Saposin-A;Saposin-B-Val;Saposin-B;Saposin-C;Saposin-D 0 12552600.0 6281100.0 3035400.0 3236100.0 False True 6081709.91860032 4247451.049401891 2388468.329080972 1.0 0.698397507650188 0.39272973572384196 22.536045574614743 -7.0600569472318035 0.24399766747353077 1.1092651223766297 1.9063846311750253e-12 0.999986324981778 0.0009167796817028583 0.07317191497078925 0.008665470325953217 0.0077150901349851125 0.029266309014044152 8.708493916049496e-08 7.0600569472318035 -1.1092651223747232 down LPALTVHVTQPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPALTVHVTQPK 12 0 C9JIZ6;P07602;P07602-2;P07602-3;Q5BJH1 C9JIZ6 PSAP Prosaposin;Saposin-A;Saposin-B-Val;Saposin-B;Saposin-C;Saposin-D 0 21287100.0 7539000.0 3956800.0 9791300.0 False True 10326372.033814454 3781975.4926121626 7478796.598153359 1.0 0.36624435767255037 0.7242424128884275 23.299830145117664 -10.694485148785375 6.935845960324563 1.0034576026170088 0.545243385280613 0.6826878394947069 0.14615209403126947 0.00784960041573283 0.0003457640994203251 0.14215325316873903 0.04717038551637058 2.020760533112608e-11 10.694485148785375 -0.4582142173363958 LPATEKPVLLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPATEKPVLLSK 12 1 Q9Y4L1;A0A494C039;A0A087X054 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 10749100.0 3465000.0 914200.0 6369900.0 False True 3355005.4716451108 1279244.827490019 4701432.097096158 1.0 0.3812944086981615 1.4013187569529757 21.67788368862857 -6.7424951087046 1.6774465024409981 0.6329439847727136 1.4022628656600638 0.6161472305236908 0.2599442468918745 0.3133161256163477 1.7319646572880332 0.12254269977201761 0.29990246775563123 1.809276287337379e-07 6.7424951087046 0.7693188808873501 LPAVSSVACGASVGYAVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPAVSSVACGASVGYAVTK 19 0 P18754;P18754-2 P18754 RCC1 Regulator of chromosome condensation 0 27695500.0 5478500.0 11987000.0 10230000.0 False True 7182366.5538694635 10198586.324960027 9171497.733089194 1.0 1.4199479027515785 1.2769464861338908 22.77602785250707 -10.066842100283969 5.039824754537371 0.9999930946661421 1.3484471944443048 0.8878480914821439 0.05838008387353354 4.5298162422676926e-06 8.386927640055656e-07 0.05652739306220412 0.01884209104858461 8.573495015874357e-11 10.066842100283969 0.3484540997781628 LPAVSSVACGASVGYAVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPAVSSVACGASVGYAVTK 19 0 P18754;P18754-2 P18754 RCC1 Regulator of chromosome condensation 0 12099700.0 6192200.0 1670000.0 4237500.0 False True 5995632.00043891 2336839.7089349497 3127571.627724921 1.0 0.3897570279102989 0.5216416930685485 22.515480405672886 -9.897355066221545 6.835556761257567 1.0000000157996267 0.4556993604902126 0.9578246969207097 0.053841689089278215 1.2950580790125189e-08 2.045611066704616e-09 0.05213199284725358 0.017377330431200814 1.266615895029739e-10 9.897355066221545 -0.5443006553094141 LPAVSSVACGASVGYAVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPAVSSVACGASVGYAVTK 19 0 P18754;P18754-2 P18754 RCC1 Regulator of chromosome condensation 0 20629100.0 5478500.0 6753000.0 8397600.0 False True 7504049.500895663 6454630.130815296 6414259.834000861 1.0 0.8601529254364446 0.8547731239293228 22.83923791402996 LPAVSSVACGASVGYAVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPAVSSVACGASVGYAVTK 19 0 P18754;P18754-2 P18754 RCC1 Regulator of chromosome condensation 0 11217700.0 6192200.0 1768900.0 3256600.0 False True 5149088.660972138 1759370.584600842 3937540.0031828783 1.0 0.341685820626106 0.7647061960746037 22.295885681107162 -10.085849945924805 5.54302576974622 1.000003827892539 0.5531960083504871 0.5979862287025439 0.17269734510873083 8.169477430438417e-06 1.3476700670583464e-06 0.1672149176955321 0.05573782846162319 8.206350348314879e-11 10.085849945924805 -0.44680781954205184 LPAVSSVACGASVGYAVTK(ub)DGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPAVSSVACGASVGYAVTKDGR 22 1 P18754;P18754-2 P18754 RCC1 Regulator of chromosome condensation 1 10479800.0 2245200.0 3062500.0 5172100.0 True False 2943478.9425477255 2605586.9375315 4636940.706286478 1.0 0.8852065832263901 1.5753266107190078 21.489090876067536 -6.864154646805722 1.1644821238250465 0.9368806417784493 1.6115106728176456 0.9584979587896372 0.06150889352239147 0.14258766418985036 0.3650627772625076 0.041120589848372385 0.09648817352359702 1.3672418812565667e-07 6.864154646805722 0.6746300310391963 LPAVSSVACGASVGYAVTK(ub)DGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPAVSSVACGASVGYAVTKDGR 22 1 P18754;P18754-2 P18754 RCC1 Regulator of chromosome condensation 1 8286100.0 4782400.0 3503700.0 0.0 True False 4630585.32975341 4902745.681554125 0.0 1.0 1.0587745030961795 0.0 22.142763138394724 -6.983467605976812 1.1476672421416947 1.0424108099546088 1.8021638135860885e-18 0.9804189812130433 0.06798615020250484 0.09607294227826794 0.24902191679361355 0.04973570822234328 0.09217580971537528 1.0388010837004519e-07 6.983467605976812 -1.0424108099546088 down LPAVSSVACGASVGYAVTK(ub)DGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPAVSSVACGASVGYAVTKDGR 22 1 P18754;P18754-2 P18754 RCC1 Regulator of chromosome condensation 1 12940700.0 4782400.0 2225500.0 5932800.0 True False 3976777.496242558 2213510.789772839 7173321.04983215 1.0 0.5566091620323906 1.8038024648373798 21.923168413829 -6.810584867646653 1.4119634426116696 0.7585166656936112 1.8259382203733083 0.8613706213796485 0.1921974945665806 0.20600659432592566 0.809333046512361 0.10702611930012894 0.24752114018197502 1.546732219770663e-07 6.810584867646653 1.0674215546796972 LPAVSSVACGASVGYAVTK(ub)DGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPAVSSVACGASVGYAVTKDGR 22 1 P18754;P18754-2 P18754 RCC1 Regulator of chromosome condensation 1 23457900.0 5631700.0 6541200.0 11285000.0 True False 7290346.667403419 6177176.469823073 9231245.793878235 1.0 0.8473090172024946 1.2662286465954986 22.797555987916503 -6.8081019441923525 1.4227499353880653 0.9165964009850794 1.273225806843505 0.8547435401626997 0.0659744197714816 0.20940611373608517 0.835827499105623 0.036467538725335445 0.0844219146476965 1.555600434600125e-07 6.8081019441923525 0.3566294058584255 LPAYLTIQMVR ddPTM_RPMI8226_Bortezomib_1h_R1 2 LPAYLTIQMVR 11 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 32515400.0 7542700.0 14462000.0 10510700.0 False True 9888552.743610704 12304325.972434489 9423153.589753732 1.0 1.2442999791233038 0.9529355643921017 23.23732795760876 -6.6842600390298115 1.8864184175311831 1.153970454532381 0.9539947881787307 0.343922775808743 0.10344406769358924 0.42910041187206655 2.9557263093016863 0.04393951372987801 0.11527299172149484 2.068902197845189e-07 6.6842600390298115 -0.19997566635365027 LPAYLTIQMVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPAYLTIQMVR 11 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 38575000.0 14949000.0 10359000.0 13267000.0 False True 14474452.177668879 14495402.721471349 9791974.698531346 1.0 1.001447415318059 0.6765005389038738 23.78700541100868 -6.905895423865402 0.9232191421409879 1.011413064962041 0.6379925544465135 0.9892786120546644 0.01582583056245736 0.10719568651319493 0.15394767160390063 0.012699416216398703 0.03413560571316486 1.241951327816744e-07 6.905895423865402 -0.3734205105155275 LPAYLTIQMVR ddPTM_RPMI8226_Bortezomib_8h_R1 2 LPAYLTIQMVR 11 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 184738900.0 48967800.0 50630000.0 85141100.0 False True 74287732.62570539 41594680.92600442 68312924.26633017 1.0 0.5599131842612145 0.9195720726936308 26.14662065773113 -9.964338119971131 6.8405100401122985 1.000000021426318 0.7397426284774218 0.41113194031009237 0.1468301263526711 4.794232379968244e-08 7.432651111244866e-09 0.1421676691136549 0.04738921950711827 1.085580116119822e-10 9.964338119971131 -0.26025739294889627 LPAYLTIQMVR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LPAYLTIQMVR 11 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 55423300.0 7542700.0 21109600.0 26771000.0 False True 10331440.023803186 20176908.071887795 20448241.166051853 1.0 1.9529618354654417 1.979224688808143 23.30053801913165 -11.017331105272744 0.6156567068319607 5.339967841912639e-22 1.9757981523767272 0.9999308000130224 0.003789532356113859 2.962457872033577 0.305587638036602 4.191603370741589 0.0044777486750497445 9.608794264410711e-12 11.017331105272744 1.9757981523767272 LPAYLTIQMVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPAYLTIQMVR 11 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 31065200.0 14949000.0 8352200.0 7764000.0 False True 12430755.852988025 8307205.040818111 9387416.503319971 1.0 0.6682783524238616 0.7551766452772447 23.567410686442955 -9.914608157265873 6.439747768477916 1.000000029522526 0.7117274988505384 0.9361965217319109 0.0354760795016769 1.5023077124139415e-08 2.5434463580823003e-09 0.03434956985758939 0.011449855424885632 1.2172838011430318e-10 9.914608157265873 -0.28827253067198755 LPAYLTIQMVR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LPAYLTIQMVR 11 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 159665200.0 48967800.0 59728400.0 50969000.0 False True 63389782.39964432 56404462.034516715 41693164.986103706 1.0 0.8898036860090751 0.6577268986860829 25.91774697982358 -6.959021955092486 0.44900499552376677 1.007560570034242 0.5307850372010321 0.9997321868108209 0.0023345398536740425 0.08005236182797731 0.02243628229477425 0.003097386616235081 0.019199452866519924 1.0989502822795608e-07 6.959021955092486 -0.47677553283320995 LPCIFICENNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPCIFICENNR 11 0 P08559;P08559-4;P08559-3;P08559-2 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 0 10496900.0 3491600.0 3215500.0 3789800.0 False True 4577521.412702495 2735759.9339208337 3397667.8503285856 1.0 0.5976509309883675 0.7422505640061348 22.12613520399287 -10.120612482165113 5.596238579967819 1.0000039565476408 0.6699507474971993 0.8741573752097112 0.05903255298138828 2.9141760964226437e-06 4.5781427940600217e-07 0.057158708282501615 0.019052674548392077 7.57508512936017e-11 10.120612482165113 -0.33005320905044155 LPCIFICENNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPCIFICENNR 11 0 P08559;P08559-4;P08559-3;P08559-2 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 0 13438700.0 3491600.0 3865100.0 6082000.0 False True 4782538.8769421 3694327.1018235083 4645556.86272187 1.0 0.7724614889457246 0.9713578879869316 22.18934526551576 -10.217019950527826 6.700375839397989 1.0000007265335362 0.8719096885338924 0.3560809453031947 0.08119911488799114 8.812717819545719e-07 1.0298598027956968e-07 0.0786211512709917 0.026206901640664356 6.067084581038256e-11 10.217019950527826 -0.12809103799964383 LPCYK(ub)SLPSLVPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPCYKSLPSLVPLR 14 1 H0Y4W2;F2Z2U4;Q9Y4A5-2;Q9Y4A5 H0Y4W2 TRRAP Transformation/transcription domain-associated protein 1 14678500.0 4219500.0 2967000.0 7492000.0 True False 5462225.928779709 2801883.841797389 6128532.874411681 1.0 0.5129564170963073 1.1219845085720994 22.38105755746419 -6.693775008104466 1.8532878326138995 0.6957301342114917 1.1199617762983056 0.38796755297963725 0.20583176252317237 0.4086339901508948 2.724097818085538 0.08875897582395108 0.23001647079812315 2.0240675015572784e-07 6.693775008104466 0.42423164208681396 LPDDTTFPLPPPRPK(ub)NVIFEDEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPDDTTFPLPPPRPKNVIFEDEEK 24 2 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2;B0QYS5 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 58032600.0 14418300.0 27170300.0 16444000.0 True False 18902530.927015837 23116597.148999903 14742532.621986195 1.0 1.2229366129993338 0.7799237403133091 24.17207607915509 -6.769856266673198 1.5747665993234272 1.127889185835892 0.777430137745798 0.7301371446082143 0.09395400401094943 0.2666397633748245 1.3049134650729928 0.047025900510803194 0.11196674381791902 1.6988057931681316e-07 6.769856266673198 -0.350459048090094 LPDDTTFPLPPPRPK(ub)NVIFEDEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPDDTTFPLPPPRPKNVIFEDEEK 24 2 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2;B0QYS5 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 131311900.0 39475000.0 38771900.0 53065000.0 True False 38221887.73252257 54253721.86278742 39165684.584123425 1.0 1.419441191456997 1.0246925755788296 25.187895697238954 -10.685793581952405 8.073935143153127 0.9993549378592883 1.2220668835179131 0.2967423659153662 0.161155447595238 0.001876424826224509 7.30230571727506e-05 0.15646888863008776 0.052012697057246565 2.0616095534011418e-11 10.685793581952405 0.22271194565862484 LPDDTTFPLPPPRPK(ub)NVIFEDEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPDDTTFPLPPPRPKNVIFEDEEK 24 2 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2;B0QYS5 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 203754600.0 54572600.0 110490000.0 38692000.0 True False 82790623.99147119 90772196.23768984 31044509.240693983 1.0 1.0964067168649543 0.3749761475875829 26.302964056490158 -6.873209997094576 1.1169192487510555 1.0557457087644908 0.3300553623020328 0.9677859110185851 0.05739745057277528 0.1338171217471528 0.3100517962596781 0.03979773495112377 0.09478859354097993 1.3390290618664875e-07 6.873209997094576 -0.725690346462458 down LPDDTTFPLPPPRPK(ub)NVIFEDEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPDDTTFPLPPPRPKNVIFEDEEK 24 2 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2;B0QYS5 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 82890300.0 14418300.0 32449000.0 36023000.0 True False 19749135.14990675 31015295.885506492 27515109.316973075 1.0 1.5704634987853094 1.3932311014187877 24.23528614067798 -10.190281028079072 4.58847507045333 0.9999072066988437 1.4818473001071413 0.9078793932945949 0.07235482325722808 50815410.12162294 8.69094416438708 49821.10135640705 0.0247689805238046 6.452365670988179e-11 10.190281028079072 0.4819400934082976 LPDDTTFPLPPPRPK(ub)NVIFEDEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPDDTTFPLPPPRPKNVIFEDEEK 24 2 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2;B0QYS5 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 109361900.0 39475000.0 37579300.0 32307600.0 True False 32825211.539012853 37376852.851992935 39062969.78653541 1.0 1.1386629696984722 1.1900294912070548 24.96830097267323 -13.999999935106377 0.1379532604301871 0.33872994046652927 1.2551934898687547 0.9996112137532939 0.0015825583083004147 11.932635516922806 0.11621711211564517 2.126701775723689 0.05818017083344452 1.0000001494231e-14 13.999999935106377 0.9164635494022254 LPDEK(ub)VELFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPDEKVELFSK 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 135748400.0 40460000.0 66082000.0 29206400.0 True False 53043451.81519729 56222823.18561848 26184401.8955715 1.0 1.059938998342304 0.4936406097174374 25.660671326438603 -6.880738211868757 1.075718740847884 1.037520034232372 0.4529421930171817 0.9742740995486522 0.04074129726935748 0.1269761090053432 0.2683763186199838 0.029156157015201568 0.07063845460194494 1.316017874838375e-07 6.880738211868757 -0.5845778412151903 down LPDEK(ub)VELFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPDEKVELFSK 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 188745800.0 60023000.0 78828000.0 49894800.0 True False 58117602.719929084 110304431.48258942 36825855.06808484 1.0 1.8979521921120979 0.6336437386371565 25.792471859002674 -6.715933412303158 1.7737882519649124 1.5486520386915934 0.6360260499105985 0.4933571778558563 0.3780610849124185 0.36326635435086346 2.2313824010833487 0.1693773728000529 0.4272734742727458 1.9233866073204669e-07 6.715933412303158 -0.9126259887809949 LPDEK(ub)VELFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPDEKVELFSK 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 267049000.0 121720000.0 94723000.0 50606000.0 True False 184658138.92396328 77818940.57582296 40603701.91860225 1.0 0.4214216661626081 0.21988579628933466 27.46028161073784 -13.913823031910736 0.14976143752953672 3.7303530258586703 9.364460015924542e-20 0.9995686373510425 0.006867297826446489 11.61246086904703 0.12131231536624723 9.253357430846052 0.19843774302290595 1.2194864190015873e-14 13.913823031910736 -3.7303530258586703 LPDEK(ub)VELFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPDEKVELFSK 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 116522600.0 40460000.0 49796700.0 26265900.0 True False 55419155.39038759 47596517.13833407 20062435.383190807 1.0 0.8588459496188867 0.3620126514355111 25.723881387961494 -6.9478147499927 0.5823409158001914 1.0058882457812144 0.190297184114321 0.9990184445951157 0.008572355189199176 0.08437528973555847 0.039686785916595434 0.008959003591629131 0.04153014177973988 1.1276783692128455e-07 6.9478147499927 -0.8155910616668933 down LPDEK(ub)VELFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPDEKVELFSK 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 192042500.0 60023000.0 97611000.0 34408500.0 True False 49911783.969757244 97085150.16873346 41603158.26307126 1.0 1.9451348448606787 0.8335337860950757 25.57287713443695 -6.681461920351699 1.896266953956957 1.59723143757435 0.8376848223022502 0.3308007391542148 0.40044795837935154 0.4354107984732688 3.028187247467341 0.16935403348631967 0.4458947817904739 2.0822749744809745e-07 6.681461920351699 -0.7595466152720998 LPDEK(ub)VELFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPDEKVELFSK 11 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 274636300.0 121720000.0 120648000.0 32268300.0 True False 157568939.45990422 113933832.74188443 26395800.50071784 1.0 0.7230729173681885 0.16751905922064447 27.23140793283029 -7.219247886184979 0.5240804331283364 1.0080284058693418 3.081247781760028e-22 0.9987755041891654 0.012112613695964313 0.08999106976040332 0.043408361306399995 0.012948951992374017 0.050971571562128525 6.036040065220488e-08 7.219247886184979 -1.0080284058693418 down LPDEKVELFSK(ub)MR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPDEKVELFSKMR 13 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 9196500.0 2794500.0 4189800.0 2212200.0 True False 2705790.127131961 5862808.989518363 1632758.4554225535 1.0 2.166764129534587 0.6034313005470303 21.367618511266784 -6.706869837564559 1.806127709952822 1.7195518400385972 0.6073799157292861 0.45041645052875257 0.4919110023034985 0.38135495967658745 2.42294463313259 0.2168910882474316 0.553155448773561 1.9639488038979267e-07 6.706869837564559 -1.112171924309311 LPDEKVELFSK(ub)MR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPDEKVELFSKMR 13 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 37081000.0 24663000.0 5398000.0 7020000.0 True False 37415574.10681653 4434684.725233498 5632493.923024702 1.0 0.11852510167485492 0.15053875444874038 25.157135576296746 -10.245284555361716 5.448795843079429 1.0000668283399958 0.13453192806175768 0.9989748574389117 0.01306951901664856 1.0610996482405377e-05 1.4697458763639453e-06 0.012655475473803504 0.00421816912450523 5.684803331247508e-11 10.245284555361716 -0.8655349002782382 LPDEKVELFSK(ub)MR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPDEKVELFSKMR 13 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 9667100.0 2794500.0 5984400.0 888200.0 True False 2323750.567340628 5952160.849389611 1073918.5134272028 1.0 2.561445678828364 0.46214879020179367 21.14802378670106 -6.707511776983317 1.80387962783611 1.9623415292632962 0.4673848599065768 0.4534197244630219 0.6582423012551465 0.3800708717787183 2.4091972250306375 0.2905476420335445 0.7404171589788883 1.9610479960237617e-07 6.707511776983317 -1.4949566693567193 LPDEKVELFSK(ub)MR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPDEKVELFSKMR 13 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 35999900.0 24663000.0 6992400.0 4344500.0 True False 31926739.68041094 6603266.793186396 3553845.578334427 1.0 0.2068255906893592 0.11131251151569775 24.928261898389195 -13.999999999999998 0.29861462371818026 8.17777929227377 0.0874724989226671 0.9996467385379222 0.007486743532764159 16.49873911753581 0.17350671310460805 73.1122721153609 0.034724735458950266 1.0000000000000041e-14 13.999999999999998 -8.090306793351104 LPDLK(ub)DAEAVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPDLKDAEAVQK 12 1 Q15388 Q15388 TOMM20 Mitochondrial import receptor subunit TOM20 homolog 1 28427200.0 11484000.0 8960900.0 7982300.0 True False 15055635.21121421 7623968.649314621 7156368.167628342 1.0 0.5063863823982596 0.4753282121433117 23.843800242200142 -13.999999999999998 0.39331615865651764 8.97167935849486 0.473213117093106 0.9998280994933683 0.0031512023670539797 25.80865203343988 0.2059341301122721 175.1347862075914 0.008097195368391513 1.0000000000000041e-14 13.999999999999998 -8.498466241401754 LPDLK(ub)DAEAVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPDLKDAEAVQK 12 1 Q15388 Q15388 TOMM20 Mitochondrial import receptor subunit TOM20 homolog 1 23166300.0 8626900.0 7237000.0 7302400.0 True False 8353043.781626312 10126771.840456435 5389682.372695813 1.0 1.2123451169658281 0.6452357384443708 22.99387056912558 -6.805286630474264 1.434214542321276 1.116386532118952 0.6363447205266495 0.8471762957203568 0.09145431368682043 0.2132962475126587 0.8655501864260332 0.05015212728464922 0.11628142858808165 1.5657173695670397e-07 6.805286630474264 -0.4800418115923024 LPDLK(ub)DAEAVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPDLKDAEAVQK 12 1 Q15388 Q15388 TOMM20 Mitochondrial import receptor subunit TOM20 homolog 1 75114000.0 30299000.0 25157000.0 19658000.0 True False 45965798.15360807 20667536.797461864 15772587.683592534 1.0 0.4496285853319741 0.3431374699702559 25.45405745610012 -13.999999999999957 0.2309441764631928 4.489582060572137 0.2918235377636698 0.999511097711946 0.006364682591411713 13.320865562349445 0.15215519512760886 21.32654068843142 0.054955556229683254 1.0000000000000981e-14 13.999999999999957 -4.197758522808467 LPDLK(ub)DAEAVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPDLKDAEAVQK 12 1 Q15388 Q15388 TOMM20 Mitochondrial import receptor subunit TOM20 homolog 1 29729100.0 11484000.0 8315900.0 9929200.0 True False 15729945.143430853 7948476.040996121 7584127.458292993 1.0 0.5053085671004751 0.4821458300800419 23.907010303723034 LPDLK(ub)DAEAVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPDLKDAEAVQK 12 1 Q15388 Q15388 TOMM20 Mitochondrial import receptor subunit TOM20 homolog 1 25365800.0 8626900.0 8084300.0 8654600.0 True False 7173649.586470164 8040748.271292082 10464236.845650844 1.0 1.1208727404886498 1.4587047665928483 22.774275844559856 -6.953030681934847 0.5245181847777698 0.9944533191131797 1.6003173110046536 0.999418156753875 0.004682500274496306 0.0822911300876354 0.03109895403345224 0.005267319075021609 0.027918397124267334 1.1142158139532006e-07 6.953030681934847 0.6058639918914739 LPDLK(ub)DAEAVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPDLKDAEAVQK 12 1 Q15388 Q15388 TOMM20 Mitochondrial import receptor subunit TOM20 homolog 1 89631000.0 30299000.0 25035000.0 34297000.0 True False 39222652.78258008 23641780.242466345 28055297.916937687 1.0 0.6027583186052716 0.7152830297444303 25.22518377819257 -10.334893560862175 8.423265403464322 1.0000008518438444 0.6590206741748525 0.9244902032049535 0.04593802095750152 7.348875959358331e-07 5.799188253383555e-08 0.04447940886876935 0.014826432510510882 4.6249435801944513e-11 10.334893560862175 -0.3409801776689918 LPECAK(ub)LAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPECAKLAK 9 1 O00232;O00232-2;J3KTJ5;J3KSK1 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 1 12267500.0 1755900.0 2483700.0 8027900.0 True False 2663828.673484942 2040464.329763327 6441182.046246437 1.0 0.7659893258427535 2.4180166353640864 21.34506986649986 -6.8710159504623665 1.1287635339214548 0.8668142285005697 2.516630427544724 0.9656838400166031 0.135210370290776 0.13588155338283492 0.3229626541559663 0.0929082276390168 0.22035121913520522 1.345810925150878e-07 6.8710159504623665 1.6498161990441544 up LPECAK(ub)LAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPECAKLAK 9 1 O00232;O00232-2;J3KTJ5;J3KSK1 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 1 2251260.0 585200.0 708140.0 957920.0 True False 486619.72875567566 704325.1092652146 1158216.6430783467 1.0 1.4473829720513562 2.380126769705775 18.89243528628939 -6.959223639273325 0.44624003869679374 0.9687377735799755 2.8955177166223076 0.9997403144083962 0.009264877470251467 0.07997962186589791 0.02216482782392595 0.012399541083917687 0.07719859524592086 1.0984400537590416e-07 6.959223639273325 1.926779943042332 LPECAK(ub)LAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPECAKLAK 9 1 O00232;O00232-2;J3KTJ5;J3KSK1 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 1 8814200.0 1755900.0 1680300.0 5378000.0 True False 2273047.1639635707 1586789.827897589 4399259.18293994 1.0 0.6980892667139659 1.935401628564908 21.11619618859231 -6.842203609276782 1.2721030396911588 0.8394082965048133 1.9779107911663838 0.9281813254151656 0.14116032124309197 0.1662392389129785 0.5216079064340414 0.08697828977671278 0.20051739312328168 1.4381241877473035e-07 6.842203609276782 1.1385024946615705 LPEEEGLGEK(ub)TK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPEEEGLGEKTK 12 1 H3BUB4;O95149 H3BUB4 SNUPN Snurportin-1 1 3288600.0 687260.0 800640.0 1800700.0 True False 665443.3074871039 1120339.727282443 1329042.6501579406 1.0 1.6835990604716615 1.9972289678241255 19.343956235252918 -10.258303519617439 0.17383771446546983 2.0567776302323234e-21 2.349178363763848 0.9995642099050664 0.008691579291269631 1.909732979854028 0.08560829620662729 1.0814523642795955 0.23089912025026815 5.5169173833490814e-11 10.258303519617439 2.349178363763848 LPEEEGLGEK(ub)TK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPEEEGLGEKTK 12 1 H3BUB4;O95149 H3BUB4 SNUPN Snurportin-1 1 3210460.0 685060.0 1181500.0 1343900.0 True False 938345.1950503947 1129297.423301978 1026498.4984893001 1.0 1.2034989141083927 1.0939454945833351 19.83975922827856 -10.108018129700111 4.659011190956229 0.9999896100167921 1.1487222043485403 0.7107476238332338 0.04472499624473844 4.827266117508832e-06 9.242277871794864e-07 0.04330781619255105 0.014434930466626398 7.797975570565755e-11 10.108018129700111 0.14873259433174824 LPEEEGLGEK(ub)TK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPEEEGLGEKTK 12 1 H3BUB4;O95149 H3BUB4 SNUPN Snurportin-1 1 3393460.0 687260.0 1381600.0 1324600.0 True False 571487.1407802899 1374157.0465738706 1601567.735741583 1.0 2.404528376084966 2.8024562959629407 19.124361510687194 -10.059143252887228 0.30257825270796374 2.4422877019999345e-16 2.9368418905851628 0.9989097409437586 0.025528805645468725 1.4777897276965186 0.13700160030817837 1.4017437652170415 0.14016729901374828 8.726834645543355e-11 10.059143252887228 2.9368418905851623 LPEEWSQWLGGSSWPGYVRPLPPAAIESPAVAAPAYSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPEEWSQWLGGSSWPGYVRPLPPAAIESPAVAAPAYSR 38 1 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 116082000.0 19445000.0 72209000.0 24428000.0 False True 29499486.61991839 59322739.77850789 19599795.09282726 1.0 2.010975327904605 0.6644113962170872 24.814186511657454 -6.705787852584777 1.8100914805417425 1.6241749390803706 0.6679325881120927 0.4451473854657807 0.426310271786092 0.3835999609839947 2.4472383677370018 0.18760840643043472 0.47908676788619065 1.9688478123399466e-07 6.705787852584777 -0.9562423509682779 LPEEWSQWLGGSSWPGYVRPLPPAAIESPAVAAPAYSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPEEWSQWLGGSSWPGYVRPLPPAAIESPAVAAPAYSR 38 1 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 40902000.0 19445000.0 11266000.0 10191000.0 False True 25171935.81825368 10639037.19639008 8336342.568490304 1.0 0.4226547085296108 0.33117606165375335 24.585312833749903 -13.999999999999998 0.25931319544337006 5.211351643026353 0.29752061525405443 0.9995609354999009 0.0062042188318948 14.386824197470979 0.16114228452497803 31.73621617001454 0.04013833292385098 1.0000000000000041e-14 13.999999999999998 -4.913831027772298 LPEGDLGK(ub)EIEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPEGDLGKEIEQK 13 1 I3L397;I3L504;P63241;P63241-2;Q6IS14 I3L397 EIF5A;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-1-like 1 68693000.0 31517000.0 20839000.0 16337000.0 True False 41319092.211062156 17729902.42978578 14646603.95556972 1.0 0.4290970948543502 0.35447545364146354 25.300305222456487 -13.999999999999998 0.28682678521790655 5.832571917902949 0.3334827550712837 0.9996203663632143 0.005617846171095889 15.779792621436203 0.16977184713153368 44.91282570325882 0.02859264949547136 1.0000000000000041e-14 13.999999999999998 -5.499089162831665 LPEGDLGK(ub)EIEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPEGDLGKEIEQK 13 1 I3L397;I3L504;P63241;P63241-2;Q6IS14 I3L397 EIF5A;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-1-like 1 114883000.0 38993000.0 38835000.0 37055000.0 True False 37755188.55868911 54342018.02184959 27349183.87382818 1.0 1.4393258276905925 0.7243821291294794 25.17017158662312 -6.740441178729543 1.6850971807144626 1.2612618646941498 0.7239232061304085 0.6069293315978797 0.184583936198916 0.31701133066832743 1.7676628029216765 0.08665072233098245 0.2125288900028536 1.817853251249431e-07 6.740441178729543 -0.5373386585637413 LPEGDLGK(ub)EIEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPEGDLGKEIEQK 13 1 I3L397;I3L504;P63241;P63241-2;Q6IS14 I3L397 EIF5A;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-1-like 1 103989000.0 26082000.0 31972000.0 45935000.0 True False 39568300.849612296 26266346.801623862 36855927.11597423 1.0 0.6638229652937252 0.9314508413199997 25.237841778335124 -9.889683036234437 6.132294734300874 1.0000000314297157 0.7976369033068026 0.43256693137844837 0.10925862286841452 4.6942317901625454e-08 8.483059704657513e-09 0.10578922246343841 0.035263068899879235 1.2891901058299435e-10 9.889683036234437 -0.20236312812291313 LPEGDLGK(ub)EIEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPEGDLGKEIEQK 13 1 I3L397;I3L504;P63241;P63241-2;Q6IS14 I3L397 EIF5A;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-1-like 1 95271000.0 31517000.0 35308000.0 28446000.0 True False 43169686.61489984 33747975.81205781 21727640.663759686 1.0 0.7817516979706273 0.5033078154489192 25.36351528397938 -6.9678074860794315 0.30605837296283905 1.0449430638312724 0.2313156997197426 0.999959876819503 0.0012875542894780416 0.07702072460152527 0.011563257041410206 0.004486282746044785 0.02481680554934483 1.0769424945658972e-07 6.9678074860794315 -0.8136273641115298 LPEGDLGK(ub)EIEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPEGDLGKEIEQK 13 1 I3L397;I3L504;P63241;P63241-2;Q6IS14 I3L397 EIF5A;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-1-like 1 84459000.0 38993000.0 26383000.0 19083000.0 True False 32424407.182792354 26240869.542384513 23073167.07017711 1.0 0.8092937334043397 0.7115987330193057 24.950576862057396 -13.999999999057714 0.08561367096027253 1.996816857110957 0.44790329633226955 0.9998625082494704 0.001404291109488869 12.204157695893395 0.08391206905517379 2.249833256003838 0.2379427201312962 1.0000000021696942e-14 13.999999999057714 -1.5489135607786875 LPEGDLGK(ub)EIEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPEGDLGKEIEQK 13 1 I3L397;I3L504;P63241;P63241-2;Q6IS14 I3L397 EIF5A;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-1-like 1 106691000.0 26082000.0 31142000.0 49467000.0 True False 33763663.153082654 29408920.323981863 40464513.574282244 1.0 0.8710227972197028 1.1984633714303536 25.008968100427573 -6.799901241530156 1.4568011109556032 0.9288282606243098 1.2029471613609786 0.8317294280885884 0.0552454267011023 0.22090759432835605 0.9256636214131354 0.02983659685019587 0.06937807534555004 1.5852536378061896e-07 6.799901241530156 0.2741189007366688 LPEIYIQLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPEIYIQLQR 10 0 Q9H223 Q9H223 EHD4 EH domain-containing protein 4 0 20857800.0 7540900.0 6632200.0 6684700.0 False True 9761843.70336175 6263112.239827655 5468153.190814171 1.0 0.6415911205042943 0.560155781733226 23.218722222286047 -13.999999999999998 0.20821140206206928 3.0577200992551874 0.5113504317784885 0.9994890849429108 0.004318714407225871 12.705415682965695 0.1446408209828459 10.686184360408332 0.04884995524679498 1.0000000000000041e-14 13.999999999999998 -2.546369667476699 LPELSQHLDTLQRTANK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPELSQHLDTLQRTANK 17 1 F8VZ81;Q9Y2I9-3;Q9Y2I9-2;Q9Y2I9 F8VZ81 TBC1D30 TBC1 domain family member 30 1 187515000.0 64965000.0 38850000.0 83700000.0 True False 98556654.57768065 31916913.963564537 67156658.31298676 1.0 0.32384331733184163 0.6814015613735656 26.55444995001197 -10.66569875056437 6.7998069309940625 1.0026515647391752 0.5026224393531316 0.7206693780045665 0.14597254187129455 0.005888869732679724 0.0002895159321831174 0.14184593715706795 0.04711243530592403 2.159241653093031e-11 10.66569875056437 -0.5000291253860436 LPENYTDETWQKLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPENYTDETWQKLK 14 1 A0A669KAX4;K4DI93;Q13620-3;Q13620-1;Q13620 A0A669KAX4 CUL4B Cullin-4B 0 26377100.0 3327900.0 8066200.0 14983000.0 False True 3222257.63610036 11287075.724677315 11058502.819634823 1.0 3.502847071637995 3.4319114324508333 21.61964041888221 -10.14116466183432 4.548453838454023 0.999694924925221 3.467379252100469 0.9993804885914301 0.028959353620910903 10120185.8528463 19.639838559613224 32443.738426580334 0.009913556989696065 7.224958189033683e-11 10.14116466183432 2.467684327175248 LPEYFFENK(ub)NSDEINIPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPEYFFENKNSDEINIPR 18 1 Q9BXW9;Q9BXW9-1;Q9BXW9-3;Q9BXW9-4 Q9BXW9 FANCD2 Fanconi anemia group D2 protein 1 10306000.0 1781600.0 2149300.0 6375100.0 True False 1725044.083198533 3007526.698451428 4705270.0610995125 1.0 1.7434491835564854 2.7276230833331057 20.718201799504417 -6.967250550795362 0.31705933523535745 0.8604809748382919 3.6421985648589175 0.9999523047050588 0.0048866545103454 0.0772053393316664 0.012209181443407576 0.015100054438170326 0.08679877882014969 1.0783244417111158e-07 6.967250550795362 2.7817175900206257 LPFAAAQIGNSFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPFAAAQIGNSFR 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 54907000.0 20499000.0 18699000.0 15709000.0 False True 26874387.512598403 15909182.08813112 14083583.371368347 1.0 0.5919830574993785 0.5240522547636156 24.679728539188755 -13.999999999999998 0.2522666853787362 3.8703021222881806 0.497321286771628 0.9995469948235423 0.004473663902394769 14.089057934313791 0.15893114921569867 20.520156945283993 0.03095966536644738 1.0000000000000041e-14 13.999999999999998 -3.3729808355165525 LPFAAAQIGNSFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPFAAAQIGNSFR 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 50043300.0 17378000.0 7041300.0 25624000.0 False True 16826344.902236268 9852927.80989441 18912305.69647753 1.0 0.5855655442189902 1.1239699296764107 24.004218485911487 -6.701076375332871 1.8267954107371511 0.7429307829813869 1.122414442986212 0.42281532609829875 0.17490290964981034 0.393277168536388 2.5522539364510797 0.07635633227525139 0.19612500791508802 1.9903232885554256e-07 6.701076375332871 0.37948366000482503 LPFAAAQIGNSFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPFAAAQIGNSFR 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 50361000.0 8795000.0 29415000.0 12151000.0 False True 13342658.000626514 24165663.42955602 9749349.524027511 1.0 1.8111581236977898 0.7306902060721128 23.669542759695208 -6.705824966077374 1.810373118896455 1.5007938720475016 0.7335518780874924 0.4451954159840781 0.34204817739226884 0.38349079227838134 2.4474213942493126 0.150516449605331 0.3842899935658575 1.9686795677509943e-07 6.705824966077374 -0.7672419939600091 LPFAAAQIGNSFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPFAAAQIGNSFR 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 58920000.0 20499000.0 16455000.0 21966000.0 False True 28078034.26464551 15727963.69059169 16778083.203970518 1.0 0.5601518803755993 0.5975519171260739 24.742938600711646 -10.514444205472115 5.790889030949977 1.000649583705898 0.5788518987508364 0.9941200380306715 0.01526850106666738 0.00012823754026124987 1.0752475427789698e-05 0.014805348436620456 0.004927887529396015 3.0588331946106806e-11 10.514444205472115 -0.42179768495506154 LPFAAAQIGNSFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPFAAAQIGNSFR 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 36199700.0 17378000.0 8490700.0 10331000.0 False True 14450576.975933246 8444958.91382801 12491164.334853018 1.0 0.5844028877111751 0.8644059234213597 23.784623761345763 -10.162320671148885 5.374632485240961 1.000008670686506 0.7244044055661909 0.5636405234369675 0.1143107606536437 1.1876948115374994e-05 1.8511122040460629e-06 0.11068439847368969 0.03689363935861646 6.881440020311783e-11 10.162320671148885 -0.275604265120315 LPFAAAQIGNSFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPFAAAQIGNSFR 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 47859000.0 8795000.0 26108000.0 12956000.0 False True 11385300.875368547 24655066.84922352 10598140.939786138 1.0 2.165517373595577 0.9308617361807816 23.440669081787657 -6.659232421908871 1.976085659844119 1.7507303031495285 0.9360680784183855 0.23214470907853835 0.49634751716350267 0.48627142369785453 3.649603649229586 0.20301061814593951 0.5500165499092476 2.1916317232148498e-07 6.659232421908871 -0.814662224731143 LPFPIIDDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPFPIIDDR 9 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 17159400.0 1118200.0 9972000.0 6069200.0 False True 1465971.0286642052 8484216.470551545 5441217.403877314 1.0 5.787438022074948 3.7116814026231872 20.48342516173486 -10.445459846033447 7.207789320955891 0.9996224524369769 4.749559712349067 0.8131041158088897 0.8474240913102288 0.005141659515445445 0.00039557837456179374 0.8205650517232385 0.2735049494016224 3.585420968023363e-11 10.445459846033447 3.7499372599120906 LPFPIIDDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPFPIIDDR 9 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 13581500.0 4393600.0 2961500.0 6226400.0 False True 4254127.572935054 4144042.3940184815 4595519.052003883 1.0 0.9741227367940399 1.0802494690664135 22.02043186686373 -6.8422584562249815 1.2719016346266967 0.9862356120269304 1.0838982518322926 0.9282628903132107 0.01210137407910148 0.16617709503749417 0.5212319596571188 0.007457685832863789 0.017192526581621764 1.4379425788490464e-07 6.8422584562249815 0.09766263980536216 LPFPIIDDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPFPIIDDR 9 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 20306600.0 1118200.0 10179000.0 9009400.0 False True 1531628.7582187725 9729258.122548316 6881565.274417368 1.0 6.352229984153002 4.492972097507736 20.546635223257752 -9.936769778316885 7.4886223486841645 0.9999999517443574 5.42260104083037 0.8829619709526114 0.7590388537543905 6.127725809306571e-07 8.774433314459281e-08 0.7349362099282565 0.24497873664292588 1.156725265559336e-10 9.936769778316885 4.4226010890860135 LPFTPLSYIQGLSHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPFTPLSYIQGLSHR 15 0 Q9UM00-1;Q9UM00-2;Q9UM00;J3QQY2;J3KS45 Q9UM00-1 TMCO1 Transmembrane and coiled-coil domain-containing protein 1 0 8810000.0 1645200.0 3389900.0 3774900.0 False True 2156873.132139462 2884140.1337267063 3384309.55939769 1.0 1.3371858041858253 1.569081421140751 21.04050988860598 -7.398324669979824 0.07179791697945886 1.2837044351796558e-12 2.813906301907596 0.9999995488895426 0.0001568230327428981 0.12472163888002166 0.005078186639232339 0.08389529882191103 0.11203268915439792 3.99645870694775e-08 7.398324669979824 2.813906301906312 LPFTPLSYIQGLSHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPFTPLSYIQGLSHR 15 0 Q9UM00-1;Q9UM00-2;Q9UM00;J3QQY2;J3KS45 Q9UM00-1 TMCO1 Transmembrane and coiled-coil domain-containing protein 1 0 8539100.0 3182300.0 2056000.0 3300800.0 False True 3081279.628402952 2876971.521898357 2436221.4581225794 1.0 0.9336937470324661 0.7906525054284961 21.555098183283526 -6.958537603483209 0.4555759741425 1.0043587701588566 0.7142637937880763 0.99971205249124 0.001482377870571505 0.08022770430883931 0.02309318967734671 0.0019284872291558135 0.011822804437503791 1.100176582140331e-07 6.958537603483209 -0.2900949763707803 LPFTPLSYIQGLSHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPFTPLSYIQGLSHR 15 0 Q9UM00-1;Q9UM00-2;Q9UM00;J3QQY2;J3KS45 Q9UM00-1 TMCO1 Transmembrane and coiled-coil domain-containing protein 1 0 11543600.0 1645200.0 3652500.0 6245900.0 False True 2253474.899858272 3491120.4727976928 4770747.058348337 1.0 1.5492164891729034 2.117062434841579 21.10371995012887 -6.970706740731732 0.24070882796142787 0.7978865177388086 2.8848309031452977 0.9999873819528842 0.0016200009425604359 0.07607405057104077 0.008205267810694961 0.01350582632260243 0.055289545786231284 1.0697770070370976e-07 6.970706740731732 2.086944385406489 LPGEAQK(ub)IDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPGEAQKIDR 10 1 Q99418;Q15438-3;Q15438;O43739;A0A0D9SFG6;F8W8E2;K7ENQ8;A0A286YF81;G5E9B7;E5RIF2;K7ERV8;K7EKA2;M0R2J0;Q9Y6D5;Q15438-2;O43739-2;Q99418-2;Q9UIA0;Q9Y6D6 Q99418 CYTH2;CYTH1;CYTH3;ARFGEF1;ARFGEF2;CYTH4 Cytohesin-2;Cytohesin-1;Cytohesin-3;Brefeldin A-inhibited guanine nucleotide-exchange protein 2;Cytohesin-4;Brefeldin A-inhibited guanine nucleotide-exchange protein 1 1 8044390.0 840690.0 1690900.0 5512800.0 True False 1275388.192671597 1389145.6839379987 4423192.663653923 1.0 1.089194405217215 3.4681147975727438 20.282504999469268 -6.914826154402967 0.8622179713488002 0.9371033753032343 3.8095369652035944 0.9926190249936085 0.09820130773078674 0.10131252940539695 0.12209453273952131 0.0823688803208162 0.23574944038237136 1.216672930397193e-07 6.914826154402967 2.87243358990036 up LPGEAQK(ub)IDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPGEAQKIDR 10 1 Q99418;Q15438-3;Q15438;O43739;A0A0D9SFG6;F8W8E2;K7ENQ8;A0A286YF81;G5E9B7;E5RIF2;K7ERV8;K7EKA2;M0R2J0;Q9Y6D5;Q15438-2;O43739-2;Q99418-2;Q9UIA0;Q9Y6D6 Q99418 CYTH2;CYTH1;CYTH3;ARFGEF1;ARFGEF2;CYTH4 Cytohesin-2;Cytohesin-1;Cytohesin-3;Brefeldin A-inhibited guanine nucleotide-exchange protein 2;Cytohesin-4;Brefeldin A-inhibited guanine nucleotide-exchange protein 1 1 9209590.0 840690.0 2364000.0 6004900.0 True False 1088289.7774773822 2232441.3218769897 4912069.8154771365 1.0 2.051329864598849 4.513567909149292 20.053631321561717 -6.95684476144234 0.4778293496550876 0.9396750349733161 5.727504302229842 0.9996346895376154 0.028143142779981936 0.0808480800150869 0.025446533730375406 0.03456544742241352 0.2031310590874121 1.1044733433350509e-07 6.95684476144234 4.787829267256526 LPGGELNPGEDEVEGLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPGGELNPGEDEVEGLKR 18 1 O43809;H3BND3;H3BV41 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 1 16386200.0 3016900.0 2213300.0 11156000.0 True False 2921130.1608675662 3097082.2322070217 8233908.927173873 1.0 1.0602342455315987 2.818740854987588 21.478095213097035 -6.914171964688192 0.866830806293878 0.9524709758366443 3.0675170288375324 0.9924032399787523 0.07352102528371451 0.10172367696836046 0.12427712279988823 0.061462939042486696 0.1749974873748185 1.2185070192952477e-07 6.914171964688192 2.115046053000888 up LPGGELNPGEDEVEGLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPGGELNPGEDEVEGLKR 18 1 O43809;H3BND3;H3BV41 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 1 67417000.0 0.0 27652000.0 39765000.0 True False 0.0 22717284.553937912 31905430.32038134 0.0 LPGGELNPGEDEVEGLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPGGELNPGEDEVEGLKR 18 1 O43809;H3BND3;H3BV41 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 1 13023200.0 3016900.0 2144900.0 7861400.0 True False 2508686.021331165 2133344.9979706826 9505182.392993258 1.0 0.8503834197787262 3.7889087403411272 21.25850048853131 -6.894908731387678 0.9929182869064456 0.8601824462685673 4.06733242295835 0.9838578009291121 0.17169169344376603 0.11524967205341867 0.19931794235805103 0.13083201805207945 0.3324814996411727 1.2737707405837695e-07 6.894908731387678 3.207149976689782 up LPGGELNPGEDEVEGLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPGGELNPGEDEVEGLKR 18 1 O43809;H3BND3;H3BV41 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 1 52316000.0 0.0 15867000.0 36449000.0 True False 0.0 14983987.501786046 29815655.998322356 0.0 LPGGELNPGEDEVEGLKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPGGELNPGEDEVEGLKR 18 1 O43809;H3BND3;H3BV41 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 8396600.0 1970900.0 1497100.0 4928600.0 False True 1908334.8583161174 2094899.837273364 3637651.805169332 1.0 1.0977632296262032 1.9061915624069952 20.86388291469516 -6.9294844671744045 0.7510079119140658 0.9874688711777246 2.07000196865934 0.9964360938361091 0.024243889311039647 0.09290600380429397 0.07899668735435912 0.022020157011512574 0.07335701531650109 1.1762930548212207e-07 6.9294844671744045 1.0825330974816152 LPGGPTLTFQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPGGPTLTFQVK 12 0 A8MV53;A0A0A6YYI3;A0A0B4J1V8;Q9NQ55-2;Q9NQ55;Q9NQ55-3;C9J3W3;C9JHF7 A8MV53 PPAN;PPAN-P2RY11 Suppressor of SWI4 1 homolog 0 5883900.0 1206400.0 2258000.0 2419500.0 False True 1581602.0827942204 1921115.2016150632 2169153.349482825 1.0 1.2146640564743214 1.3714912069732332 20.592955245374263 -6.9745493605829765 0.10195339713225511 0.624783108537317 1.9653546002299676 0.9999997221624127 8.00551625834392e-05 0.07485237658162872 0.0029966310226238633 0.013793292805125923 0.02534878340139419 1.0603534149961398e-07 6.9745493605829765 1.3405714916926506 LPGGPTLTFQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPGGPTLTFQVK 12 0 A8MV53;A0A0A6YYI3;A0A0B4J1V8;Q9NQ55-2;Q9NQ55;Q9NQ55-3;C9J3W3;C9JHF7 A8MV53 PPAN;PPAN-P2RY11 Suppressor of SWI4 1 homolog 0 2666100.0 1206400.0 1459700.0 0.0 False True 1652438.6817341507 1395205.6274176044 0.0 1.0 0.8443312558826127 0.0 20.656165306897154 -7.185906737505583 0.9046652352732523 0.9915066560046126 2.5070347341277012e-19 0.9894714932414934 0.045079391548771136 0.09131530693819243 0.14183691844170906 0.037915618469758466 0.06655090524493444 6.517683429152531e-08 7.185906737505583 -0.9915066560046126 down LPGHAGSINEVAFHPDEPIIISASSDKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPGHAGSINEVAFHPDEPIIISASSDKR 28 1 Q96DI7;Q9NSS8 Q96DI7 SNRNP40;DKFZp434D199 U5 small nuclear ribonucleoprotein 40 kDa protein 0 12711000.0 1956500.0 2719900.0 8034600.0 False True 1894391.9784339548 3805970.2540911194 5930097.227166646 1.0 2.0090721969998087 3.13034329466962 20.853303446504786 -6.969764354667853 0.2637559904972522 0.6992930493491211 4.473552972168578 0.9999804852356952 0.00384375604864767 0.07637926289723544 0.009303500373474204 0.022851121963536364 0.10520894667594935 1.0721008623319741e-07 6.969764354667853 3.774259922819457 LPGHAGSINEVAFHPDEPIIISASSDKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPGHAGSINEVAFHPDEPIIISASSDKR 28 1 Q96DI7;Q9NSS8 Q96DI7 SNRNP40;DKFZp434D199 U5 small nuclear ribonucleoprotein 40 kDa protein 0 15522200.0 3779600.0 3801800.0 7940800.0 False True 5177020.259849463 3633823.905128616 6065346.585909547 1.0 0.7019141750923494 1.1715902742257986 22.30369053340425 -6.735224758346436 1.7042728866308974 0.8216655082737938 1.171583973516331 0.5832859956617187 0.12526500072552182 0.32652156011803335 1.8602471428053504 0.058193258286021246 0.14355125185513276 1.8398196020041803e-07 6.735224758346436 0.3499184652425371 LPGHAGSINEVAFHPDEPIIISASSDKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPGHAGSINEVAFHPDEPIIISASSDKR 28 1 Q96DI7;Q9NSS8 Q96DI7 SNRNP40;DKFZp434D199 U5 small nuclear ribonucleoprotein 40 kDa protein 0 5448000.0 1956500.0 1636500.0 1855000.0 False True 1626916.4376460698 1627683.8496801823 2242871.9234490693 1.0 1.000471697265056 1.3786030256687336 20.633708721939062 -6.90716863714608 0.9147897565127544 0.9872181440557818 1.4246240446373122 0.9898086716900607 0.018006231321645437 0.10632078712381732 0.14914001846417238 0.014538570188717273 0.0393882399331098 1.2383156534874282e-07 6.90716863714608 0.4374059005815304 LPGLGIIIYLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPGLGIIIYLLK 12 0 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 0 557200000.0 110520000.0 226390000.0 220290000.0 False True 167666920.09428555 185988935.70685655 176749584.94346294 1.0 1.1092762698943108 1.054170881436063 27.321022839035738 -10.60113694853527 6.48253618272247 0.9997878206097695 1.0817235756651868 0.7457120113643393 0.022496680633426733 6.916564662195038e-05 4.255655993728355e-06 0.021838658861881775 0.007260772453184043 2.5053191120136165e-11 10.60113694853527 0.08193575505541739 LPGLGIIIYLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPGLGIIIYLLK 12 0 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 0 278565000.0 110520000.0 43225000.0 124820000.0 False True 143070318.67489836 40819490.75217125 102104040.76135416 1.0 0.28531068589374026 0.7136633349742324 27.092149161128187 -10.49597056694421 5.9495343209025835 1.0005019667402957 0.499487010435601 0.6454402055874847 0.17487423670277824 0.0011654677312359593 9.873544227731821e-05 0.16948300187001694 0.05644041720254944 3.191754159702534e-11 10.49597056694421 -0.5010149563046946 LPGLIDVHVHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPGLIDVHVHLR 12 0 F8VPD4;P27708;H7C3Z5 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 145390000.0 25875000.0 58601000.0 60914000.0 False True 39254266.71588523 48143193.69829722 48874321.20044538 1.0 1.2264448613127412 1.2450702888984841 25.226346139497295 -12.620393637163511 0.3748890239607843 2.118847386070461e-12 1.2469522204648467 0.9997407207910731 0.001793721855847825 8.418716851915876 0.19637278989080886 6.556529786785425 0.005127162264175178 2.3966596425458076e-13 12.620393637163511 1.246952220462728 LPGLIDVHVHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPGLIDVHVHLR 12 0 F8VPD4;P27708;H7C3Z5 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 89886000.0 25875000.0 40455000.0 23556000.0 False True 33495697.572502643 38203643.687196925 19269049.70497083 1.0 1.1405537563295634 0.5752693958160531 24.997472461589744 -6.840888590079401 1.2782819059470325 1.0747638258597003 0.5563494899591015 0.9259694368873078 0.06538223035241669 0.16776234018932748 0.532108156457129 0.04010140614184191 0.09240794916811479 1.442485346017433e-07 6.840888590079401 -0.5184143359005988 LPGLLMTIIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPGLLMTIIR 10 0 P53618;E9PP73;E9PP63;E9PKQ1 P53618 COPB1 Coatomer subunit beta 0 1782920.0 279440.0 741000.0 762480.0 False True 366348.54610080953 630445.688395378 683585.8838246192 1.0 1.7208903791360914 1.8659440336266935 18.4828573646131 -11.140458494603845 0.2948945989542403 2.7301800308211895e-12 1.9104722439231308 0.9992776814332045 0.010177379345488763 3.1549247901762407 0.15360785134405036 2.1517242977946207 0.05339437786514062 7.236715600540764e-12 11.140458494603845 1.9104722439204005 LPGLLMTIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPGLLMTIIR 10 0 P53618;E9PP73;E9PP63;E9PKQ1 P53618 COPB1 Coatomer subunit beta 0 2760490.0 279440.0 809350.0 1671700.0 False True 382756.5195820546 773590.2408374585 1276878.889742215 1.0 2.0211027148072334 3.336008204736746 18.54606742613599 -6.96766886872955 0.30883923044798917 0.7946309891071506 4.604206532194522 0.9999580632942785 0.00619209588987318 0.07706663785065616 0.011724103019315184 0.02091448718884539 0.11687053691037236 1.0772862860420885e-07 6.96766886872955 3.8095755430873712 LPGPAPDK(ub)PNVYDFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPGPAPDKPNVYDFK 15 1 Q9NP77;Q9NP77-2 Q9NP77 SSU72 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 1 22319600.0 7554900.0 2640700.0 12124000.0 True False 9779966.979343018 2493742.7236381406 9917556.402745225 1.0 0.25498477948906745 1.014068495700734 23.221398163456847 -10.947633987255486 12.887553759802437 1.0772655542520337 0.6345266376860182 0.2361047205416339 0.309894629462369 0.13341955068978026 0.0005421229801973643 0.05818977618369829 0.10001806158223951 1.1281478309832933e-11 10.947633987255486 -0.4427389165660155 LPGPTLWASYSLEYGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPGPTLWASYSLEYGK 16 0 P07741-2;P07741;H3BQB1;H3BQF1 P07741-2 APRT Adenine phosphoribosyltransferase 0 10021600.0 4294300.0 1879700.0 3847600.0 False True 4157979.7970809727 2630274.0125060077 2839798.134474199 1.0 0.6325846061956673 0.6829754527590112 21.98745131772683 -10.099175082680881 5.08954538556989 1.000008902583351 0.6577800294767374 0.9839989478097658 0.02057197696740528 2.078169038826148e-06 3.6788921442954857e-07 0.019919248770413137 0.006639577015695165 7.958384492194481e-11 10.099175082680881 -0.34222887310661354 LPGPTLWASYSLEYGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPGPTLWASYSLEYGK 16 0 P07741-2;P07741;H3BQB1;H3BQF1 P07741-2 APRT Adenine phosphoribosyltransferase 0 80602000.0 20930000.0 32205000.0 27467000.0 False True 31752340.187960528 26457766.131186504 22038135.41078622 1.0 0.8332540522861507 0.6940633440032988 24.920359588478956 -6.973204962393677 0.1645020127164051 1.1324749746546987 0.39113405088071623 0.9999978068240457 0.00018512621707499887 0.07527580501674995 0.005101530900098397 0.0061732832995105204 0.016433913643086294 1.0636409214908912e-07 6.973204962393677 -0.7413409237739825 LPGPTLWASYSLEYGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPGPTLWASYSLEYGK 16 0 P07741-2;P07741;H3BQB1;H3BQF1 P07741-2 APRT Adenine phosphoribosyltransferase 0 53152000.0 20930000.0 15374000.0 16848000.0 False True 27094297.591979943 14518423.38516786 13781836.875078475 1.0 0.5358479339012424 0.5086618993643139 24.691485910571405 -13.999999999999998 0.4038953962650691 9.022645687440853 0.5072109432045047 0.9998432029131322 0.002823480458983645 27.354619927067247 0.20992365967112125 192.6015424986643 0.006882544858245334 1.0000000000000041e-14 13.999999999999998 -8.515434744236348 LPHLLLYGPPGTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPHLLLYGPPGTGK 14 0 P40937;P40937-2;C9JH72;F5H304;F5H0U6 P40937 RFC5 Replication factor C subunit 5 0 18046400.0 4683500.0 5271500.0 8091400.0 False True 6140113.85507851 4485012.748146063 7254179.54618944 1.0 0.730444557544563 1.181440559150134 22.549833976814455 -6.7447881549701885 1.6688480968484731 0.8405168194731012 1.1820088490746918 0.6264007645630234 0.11325194211578951 0.30920652600273024 1.6925429067904196 0.0536443890875481 0.13096923899219995 1.7997486025916296e-07 6.7447881549701885 0.34149202960159064 LPHLLLYGPPGTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPHLLLYGPPGTGK 14 0 P40937;P40937-2;C9JH72;F5H304;F5H0U6 P40937 RFC5 Replication factor C subunit 5 0 15831000.0 4327500.0 2049100.0 9454400.0 False True 4190125.88125374 2867316.315915337 6978009.0140796555 1.0 0.6843031443860581 1.6653459136630389 21.998562155857993 -6.8200954138971905 1.371449388781158 0.8298591038640739 1.6868098602597081 0.8846104360024523 0.1388994812677137 0.19335358715324819 0.7145712026951561 0.07958749459633853 0.18343277059258348 1.513228757647895e-07 6.8200954138971905 0.8569507563956342 LPHLLLYGPPGTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPHLLLYGPPGTGK 14 0 P40937;P40937-2;C9JH72;F5H304;F5H0U6 P40937 RFC5 Replication factor C subunit 5 0 17486100.0 4683500.0 6098900.0 6703700.0 False True 6415116.516828478 5829430.431634738 5120424.127035286 1.0 0.9087021905748186 0.798181001639349 22.613044038337346 -6.968574738421725 0.2902160484756659 1.021539366794942 0.6819281442580378 0.9999690282372513 0.00045918825347478665 0.07676792028776537 0.010677021243142945 0.0019286213823271779 0.01002005117747729 1.0750415788735683e-07 6.968574738421725 -0.3396112225369041 LPHLLLYGPPGTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPHLLLYGPPGTGK 14 0 P40937;P40937-2;C9JH72;F5H304;F5H0U6 P40937 RFC5 Replication factor C subunit 5 0 13185900.0 4327500.0 6103400.0 2755000.0 False True 3598507.9907556195 6070519.772769957 3331057.7623192403 1.0 1.6869546457489626 0.9256774671270858 21.77896743129227 -6.669060202545254 1.9414375326202296 1.4388494616144305 0.9288143612485354 0.27463749354140976 0.2918692483378754 0.4632397524292804 3.365505479747018 0.12108959993856362 0.3238316089526416 2.1425935710343123e-07 6.669060202545254 -0.510035100365895 LPHSVLLEIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPHSVLLEIQK 11 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 12592300.0 3162500.0 5193300.0 4236500.0 False True 4146068.125693562 4418479.883324847 3798147.6193775507 1.0 1.0657036376086355 0.9160842282933278 21.983312391461993 -6.7873213935619905 1.5068418666205607 1.0368498113629063 0.9146043607181328 0.7925879670871114 0.027886826340250664 0.23936543706172927 1.073699645265373 0.014568833912068018 0.03417952714667595 1.6318438776853556e-07 6.7873213935619905 -0.12224545064477355 LPHSVLLEIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPHSVLLEIQK 11 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 11624100.0 3645000.0 4001100.0 3978000.0 False True 3529291.4701721272 5598760.095460865 2936042.462558052 1.0 1.5863694293256565 0.8319070519882162 21.75094715081829 -6.6992584411686265 1.8333790310011742 1.364376774412623 0.8341749705838163 0.4140857021257325 0.24754794248886797 0.39708657763290006 2.5943348655323994 0.10773617596773223 0.27733681667055987 1.998672140295988e-07 6.6992584411686265 -0.5302018038288067 LPHSVLLEIQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPHSVLLEIQK 11 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 43901400.0 8395400.0 17999000.0 17507000.0 False True 12736435.585953344 14786937.82317113 14046733.776409313 1.0 1.1609949835163635 1.102877934851809 23.602458246203593 -10.13609923674868 4.275703604979018 0.9999747856093533 1.1319364591949992 0.8729618884755975 0.023726185819328532 6.040928056235356e-06 1.2205576802907286e-06 0.022977428674020892 0.007657593537752424 7.30972036515089e-11 10.13609923674868 0.13196167358564592 LPHSVLLEIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPHSVLLEIQK 11 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 14773600.0 3162500.0 5571700.0 6039400.0 False True 4331761.713349007 5325523.870851998 4613018.105347332 1.0 1.2294129324890046 1.064928869732513 22.046522452984885 -10.005661229280282 4.660187437444431 0.999996580090435 1.1471709011186586 0.5163051431416656 0.06715033745592798 2.386089125597899e-06 5.0895824955905e-07 0.06501954502690875 0.021672678217762142 9.870491315164685e-11 10.005661229280282 0.1471743210282236 LPHSVLLEIQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPHSVLLEIQK 11 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 10254100.0 3645000.0 3291000.0 3318100.0 False True 3030979.0008790833 3273270.7297876426 4011899.3688390064 1.0 1.079938438649125 1.3236315288477498 21.531352426252568 -6.951089311616399 0.5467521942625628 0.9965630802414104 1.4183916813429591 0.9992840287464279 0.0036830348278329202 0.08305122951352752 0.0341745097684034 0.004014370857939741 0.020204335291193067 1.1192076974263421e-07 6.951089311616399 0.42182860110154874 LPHSVLLEIQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPHSVLLEIQK 11 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 42486400.0 8395400.0 19687000.0 14404000.0 False True 10868010.798074923 18591401.143736146 11782619.797520803 1.0 1.7106535399310872 1.0841560628195075 23.373584568296042 -10.335023796798026 6.063820873869394 0.9999631115923532 1.3974048013752658 0.3491684008419379 0.25576652401072664 0.0001275759576249839 1.3990334682660448e-05 0.24766779398106828 0.08254829066757512 4.623556863172221e-11 10.335023796798026 0.3974416897829126 LPHVK(ub)YICPHAPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPHVKYICPHAPR 13 1 O95372;Q5QPQ1;Q5QPQ3;Q5QPQ2;Q5QPN5;Q5QPN9 O95372 LYPLA2 Acyl-protein thioesterase 2 1 27625400.0 1793600.0 7334800.0 18497000.0 True False 2721022.329724127 6025847.632946025 14841059.842476899 1.0 2.2145528050690273 5.454221996032488 21.375717365253948 -6.954058598090336 0.5123556587722762 0.9415127729539634 6.869962762671404 0.9994824898197097 0.04276856955858884 0.08189583197249485 0.02952601958979623 0.04906306220388866 0.26742185886183567 1.1115817346748226e-07 6.954058598090336 5.928449989717441 LPHVK(ub)YICPHAPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPHVKYICPHAPR 13 1 O95372;Q5QPQ1;Q5QPQ3;Q5QPQ2;Q5QPN5;Q5QPN9 O95372 LYPLA2 Acyl-protein thioesterase 2 1 24436000.0 1793600.0 5492400.0 17150000.0 True False 2321850.5571416724 5186743.111792375 14028875.973860163 1.0 2.233883268601725 6.042109786398352 21.146843687346397 -6.950810759002486 0.549870392856573 0.9472928912002913 7.507565424530024 0.9992633846858205 0.05824391086444204 0.08316179924192577 0.03462753914045055 0.06322708128616898 0.3159169122603413 1.1199257775389829e-07 6.950810759002486 6.560272533329733 LPHVLLLQLGTTFFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPHVLLLQLGTTFFK 15 0 O43809;H3BND3;H3BV41 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 145049000.0 54277000.0 59276000.0 31496000.0 False True 52554006.34472767 82945215.92025633 23246252.740253516 1.0 1.578285304762071 0.44233074425896035 25.647297413429524 -6.7683309669751015 1.581020234160269 1.332396000981011 0.43636685358503974 0.7240797861995458 0.24361326514465076 0.26913272910372854 1.3274317533263775 0.12147763060472029 0.28959132023292083 1.7047827136700072e-07 6.7683309669751015 -0.8960291473959712 down LPHVLLLQLGTTFFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPHVLLLQLGTTFFK 15 0 O43809;H3BND3;H3BV41 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 1326290000.0 474930000.0 330780000.0 520580000.0 False True 720503532.0338306 271749724.60406375 417687134.82168084 1.0 0.37716640172043453 0.5797155964560472 29.424430261858674 -10.191943139912327 6.567828270834346 1.0000025711326397 0.4784409990882568 0.8983807772966999 0.08269036248564682 3.113206520969993e-06 3.829250221430732e-07 0.08006499397921506 0.026688199733230267 6.42771866837214e-11 10.191943139912327 -0.5215615720443829 LPHVLLLQLGTTFFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPHVLLLQLGTTFFK 15 0 O43809;H3BND3;H3BV41 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 186997000.0 54277000.0 49407000.0 83313000.0 False True 45133730.37879666 49140834.684478395 100733363.10421136 1.0 1.0887829184968993 2.2318864906308478 25.4277026888638 -6.922403167511546 0.8067021356890215 0.9768958469861259 2.426812467102784 0.9948228957941302 0.040362443054026365 0.09677823486082504 0.09843752588108967 0.03522652178942602 0.10807144060158441 1.1956300796703398e-07 6.922403167511546 1.449916620116658 up LPHVLLLQLGTTFFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPHVLLLQLGTTFFK 15 0 O43809;H3BND3;H3BV41 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 1085740000.0 474930000.0 348600000.0 262210000.0 False True 614806247.2699006 329200103.55597186 214490470.50180012 1.0 0.5354534131977561 0.34887490401124466 29.195556583951124 -13.999999999999998 0.12573792433941725 3.2080493782238895 0.07286949105227407 0.999665315660403 0.005008556173769009 11.945408022562127 0.10982702965686478 6.545965200759325 0.24513919021281733 1.0000000000000041e-14 13.999999999999998 -3.135179887171615 LPIFFFGTHETAFLGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPIFFFGTHETAFLGPK 17 0 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 0 4224500.0 1490300.0 1471100.0 1263100.0 False True 1442991.2422489757 2058517.9016851548 932256.217812237 1.0 1.4265629904148616 0.6460581260072431 20.460631113226526 -6.758324474173763 1.6188814141176582 1.2482930679548494 0.643452848607781 0.6840182479668311 0.17937285170734477 0.2857581803105056 1.4756551858005287 0.08744027794409513 0.2104731631727631 1.7445182850102948e-07 6.758324474173763 -0.6048402193470684 LPIFFFGTHETAFLGPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPIFFFGTHETAFLGPK 17 0 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 0 19015500.0 5751000.0 8073500.0 5191000.0 False True 8724687.454417631 6632720.84645659 4164996.5747038764 1.0 0.7602244643271662 0.47738060491725526 23.05667201972519 -6.968942306940844 0.2823065805011867 1.060606532411669 0.1683523848952942 0.9999729168617433 0.0011115897653710136 0.07664739941942143 0.010252976130536563 0.0051560141012069955 0.025886787304141994 1.0741320939848317e-07 6.968942306940844 -0.8922541475163748 down LPIFFFGTHETAFLGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPIFFFGTHETAFLGPK 17 0 O75475-3;O75475-2;O75475 O75475-3 PSIP1 PC4 and SFRS1-interacting protein 0 15116700.0 5751000.0 5166600.0 4199100.0 False True 7444782.869157987 4879074.168193591 3434906.8864044417 1.0 0.6553682295297646 0.46138442809856367 22.82779834181764 -10.501664375085893 0.10779853281331134 1.8832314347459347 2.158576532919323e-21 0.9998877515753846 0.0023598367232373282 2.3798498313580936 0.057708846561866034 0.8219830723565774 0.2752448922700086 3.150181849701189e-11 10.501664375085893 -1.8832314347459347 LPIGDVATQYFADR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPIGDVATQYFADR 14 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 21651800.0 2465700.0 9090100.0 10096000.0 False True 3232556.577872765 7733892.512932285 9051362.767670432 1.0 2.3925002785323857 2.800063216102106 21.624244190373513 -10.035865001135843 0.2972630803091973 9.337893533739359e-17 2.945673294372268 0.9989138452480851 0.02539886872185453 1.4549468901587763 0.13414823889138133 1.3720673667291103 0.14668876185634985 9.20735734637368e-11 10.035865001135843 2.945673294372268 LPIGDVATQYFADR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPIGDVATQYFADR 14 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 19294500.0 6766100.0 2106400.0 10422000.0 False True 6551313.859075889 2947496.504730891 7692165.54670186 1.0 0.4499092194533719 1.1741408993931022 22.643352835957536 -6.703637736173566 1.818061438527224 0.6596385003465343 1.1721285257631797 0.4348014284095466 0.23204928938307434 0.387993001465921 2.49574815764646 0.10173306550447796 0.26044620986886813 1.9786194040388238e-07 6.703637736173566 0.5124900254166455 LPIGDVATQYFADR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPIGDVATQYFADR 14 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 22239800.0 2465700.0 8831100.0 10943000.0 False True 3377335.9230370433 8440912.801457554 8358488.7781594 1.0 2.499281384443135 2.47487634296179 21.687454251896405 -10.121357696616899 5.59120325115782 0.99998181737483 2.487078863702699 0.9997980402664963 0.009963316464294835 2.2582985094992353e-06 3.548599657414538e-07 0.009647057019749937 0.0032156465614791943 7.562098037240296e-11 10.121357696616899 1.487097046327869 LPIGDVATQYFADR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPIGDVATQYFADR 14 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 9199000.0 6766100.0 0.0 2432900.0 False True 5626311.939052936 0.0 2941608.141541372 1.0 0.0 0.5228306168243715 22.423758111391813 -10.410551532542037 5.423385734668912 1.0004694549170376 0.26141530841217947 0.7268379888520755 0.21344470552074216 0.0012123064582328276 0.00013176090969628648 0.2067911237422045 0.06888898248482798 3.885513904635281e-11 10.410551532542037 -0.7390541465048581 LPILPTLLTTLEVSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPILPTLLTTLEVSLR 16 0 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 0 135803000.0 47192000.0 64525000.0 24086000.0 False True 71593714.1973355 53010009.61387394 19325391.542731185 1.0 0.740428265360855 0.26993140053418846 26.093329591164483 -7.023337284846109 0.42236717979167865 1.0209905468451195 7.575979677753563e-12 0.9998202599905862 0.004051064938628919 0.073514075198984 0.019519887907745993 0.006094471268625155 0.03642407928311671 9.476821818043595e-08 7.023337284846109 -1.0209905468375435 down LPILQLTVQYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPILQLTVQYR 11 0 Q7Z333-3;Q7Z333;Q7Z333-4;X6RI79 Q7Z333-3 SETX Probable helicase senataxin 0 13237100.0 2401400.0 4695900.0 6139800.0 False True 3643099.3658561097 3857879.955765841 4926265.838830058 1.0 1.0589554575213347 1.3522183569847295 21.796734914575833 -6.939920363426838 0.6603055532672055 0.9967037225776537 1.4311166922524357 0.9981534333273598 0.006619074733196258 0.08780299905349809 0.05477557241737645 0.006439288320615107 0.025249421809241356 1.1483641777148908e-07 6.939920363426838 0.43441296967478193 LPIQEFHLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPIQEFHLSR 10 0 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 0 5775100.0 1448900.0 1264900.0 3061300.0 False True 1899521.9311675613 1076181.8505415826 2744546.042063141 1.0 0.5665540538824397 1.4448614659458954 20.857204938238944 -6.772525625159978 1.5648772870585896 0.7521895726135305 1.4502694299255259 0.740097127600805 0.1828052604958218 0.26236411173829 1.268323100315833 0.09206123719936068 0.21863200507603386 1.6883962342281897e-07 6.772525625159978 0.6980798573119954 LPIQEFHLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPIQEFHLSR 10 0 P39748;P39748-2;I3L3E9 P39748 FEN1 Flap endonuclease 1 0 5547700.0 1448900.0 1954500.0 2144300.0 False True 1984597.485050241 1868143.727332812 1637860.5032447404 1.0 0.9413212207540005 0.8252859915335815 20.920414999761835 -6.96026585078755 0.4316705901141973 1.0045282552248311 0.7576169005380792 0.999779926626498 0.0010769452256844268 0.07960629203996783 0.020781411179860432 0.0015155579538408553 0.009630838120222564 1.0958071989225209e-07 6.96026585078755 -0.24691135468675196 LPISASHSSK(ub)TR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPISASHSSKTR 12 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 3044200.0 613950.0 1527000.0 903250.0 True False 804894.3955002571 1299177.5521993805 809790.3545858084 1.0 1.614096904466476 1.0060827347201347 19.618439984269838 -10.266765727588862 4.940010925906406 0.9999259961584303 1.3100898195933868 0.25750245499923663 0.2482207453775518 0.00020238264131130614 3.003938597448478e-05 0.2403958949232593 0.08011290108575612 5.410461019092983e-11 10.266765727588862 0.3101638234349565 LPISASHSSK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPISASHSSKTR 12 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;H7C3P6 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 2791720.0 776780.0 1468600.0 546340.0 True False 645926.987188712 1460688.3603057226 660577.1680092529 1.0 2.261383080869746 1.0226808619412286 19.301011572523407 -6.6419543767653915 2.037187937877709 1.823645261449469 1.027832637767458 0.16218052660710047 0.5394452922993782 0.5284918379395549 4.194195539567629 0.21544804856042135 0.5974307541940731 2.280581637664866e-07 6.6419543767653915 -0.7958126236820109 LPK(ub)DFVDLSTGEDAHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPKDFVDLSTGEDAHK 16 1 O75794;X6RA30 O75794 CDC123 Cell division cycle protein 123 homolog 1 10825400.0 2538100.0 6009500.0 2277800.0 True False 3327473.67899536 5112906.02484753 2042115.1062004461 1.0 1.5365729433481896 0.6137133763345071 21.665995823490476 -6.749107714408563 1.653431617899754 1.3158504758740042 0.6120342455724311 0.6450239751499465 0.2254605828673571 0.30159518655652184 1.6220005467003709 0.10773735939416644 0.2617735107492401 1.7819367538463308e-07 6.749107714408563 -0.703816230301573 LPK(ub)DFVDLSTGEDAHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPKDFVDLSTGEDAHK 16 1 O75794;X6RA30 O75794 CDC123 Cell division cycle protein 123 homolog 1 19219600.0 4392900.0 12474200.0 2352500.0 True False 4253449.794051888 17455213.11209363 1736309.6765127755 1.0 4.10377786438278 0.4082121009023938 22.020201994552625 -6.6839948530769995 1.8878569444557602 2.9567697766759986 0.4219012588984589 0.3423573711046327 1.3143327356843502 0.42975339944106206 2.9646533412960805 0.5579642373246647 1.4640169206213116 2.0701658826539008e-07 6.6839948530769995 -2.53486851777754 LPK(ub)DFVDLSTGEDAHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPKDFVDLSTGEDAHK 16 1 O75794;X6RA30 O75794 CDC123 Cell division cycle protein 123 homolog 1 38591600.0 26982600.0 6917500.0 4691500.0 True False 40934576.892291635 5683018.078325811 3764222.9686425063 1.0 0.138831728816427 0.09195705084596452 25.28681664764668 -13.36527462765459 0.42085409070233964 9.999999999874879 0.0904259486359132 0.9998541964393758 0.005040620749718386 17.280159163380635 0.21579088674124206 140.26777099480304 0.01135227558932955 4.3124629046820923e-14 13.36527462765459 -9.909574051238966 LPK(ub)DFVDLSTGEDAHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPKDFVDLSTGEDAHK 16 1 O75794;X6RA30 O75794 CDC123 Cell division cycle protein 123 homolog 1 14021700.0 2538100.0 6876000.0 4607600.0 True False 3476504.159573474 6572195.584108676 3519379.7765007094 1.0 1.8904610155608175 1.0123329686832578 21.729205885013368 -6.6428966667209455 2.033580823952254 1.5810071574327758 1.0159684355384393 0.1659873078402201 0.38072262648723615 0.5260818417466299 4.161355959425057 0.1522581259275099 0.42170811304093203 2.2756388174532483e-07 6.6428966667209455 -0.5650387218943365 LPK(ub)DFVDLSTGEDAHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPKDFVDLSTGEDAHK 16 1 O75794;X6RA30 O75794 CDC123 Cell division cycle protein 123 homolog 1 19613800.0 4392900.0 13997100.0 1223800.0 True False 3652890.988466864 13921694.844093194 1479690.921788124 1.0 3.811144347873408 0.4050739336213144 21.8006072699869 -6.687478569335103 1.8751557727417196 2.7665590914084666 0.4171294863050828 0.35869432863961037 1.1895335356684704 0.4221419942287034 2.875804652668522 0.5078329109861104 1.3267578568732814 2.0536263620586078e-07 6.687478569335103 -2.3494296051033836 LPK(ub)DFVDLSTGEDAHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPKDFVDLSTGEDAHK 16 1 O75794;X6RA30 O75794 CDC123 Cell division cycle protein 123 homolog 1 55705600.0 26982600.0 21969500.0 6753500.0 True False 34929507.60656274 20746878.012257393 5524432.296761782 1.0 0.5939642277797057 0.1581594667462138 25.05794296973913 -7.648625728930881 0.41162210677922206 1.0395578042018712 1.5073427959218258e-24 0.998247552085838 0.014390213056728563 0.11992927398913905 0.0626763366010428 0.02581935752911218 0.07383450195109212 2.2458165144816268e-08 7.648625728930881 -1.0395578042018712 down LPK(ub)NVSSATHSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPKNVSSATHSAR 13 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 2755260.0 897330.0 1068600.0 789330.0 True False 868844.7503236096 1495297.552675384 582580.7936075786 1.0 1.7210181129809972 0.6705234662355856 19.72873888628914 -6.721929981166439 1.7519498054451854 1.437728722303569 0.6719281919081861 0.5218643870533857 0.30333556599462624 0.3515474113407347 2.1096783891932573 0.13741022248283097 0.34422532709416587 1.8970117409901906e-07 6.721929981166439 -0.765800530395383 LPK(ub)NVSSATHSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPKNVSSATHSAR 13 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 2785050.0 897330.0 1565600.0 322120.0 True False 746169.6534592124 1557165.8020527316 389473.8026853982 1.0 2.086879029231186 0.5219641416396571 19.509144161723416 -6.719930247902854 1.7597755884964315 1.6612979088595194 0.5244450461642487 0.5121123104409964 0.45736597053508404 0.3554430340874042 2.1512126028652903 0.2063770627316506 0.5180851750803124 1.9057667788517775e-07 6.719930247902854 -1.1368528626952707 LPLAQVSAHPWVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPLAQVSAHPWVR 13 0 Q96GD4-5;Q96GD4;Q96GD4-4;J3KT86;Q96GD4-2 Q96GD4-5 AURKB Aurora kinase B 0 12421400.0 4703400.0 5121500.0 2596500.0 False True 6166202.947790393 4357392.163450645 2327839.0873867134 1.0 0.7066572735839128 0.37751580787993283 22.55595094286793 -6.996153146943686 0.2701206984019633 1.0829236068526589 9.051206328282467e-13 0.9999795019139408 0.0011511797926586935 0.073699409864246 0.009483919520689508 0.006445926604418659 0.02970114019128284 1.008897052069342e-07 6.996153146943686 -1.0829236068517538 down LPLAQVSAHPWVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPLAQVSAHPWVR 13 0 Q96GD4-5;Q96GD4;Q96GD4-4;J3KT86;Q96GD4-2 Q96GD4-5 AURKB Aurora kinase B 0 11921000.0 3945700.0 1726800.0 6248500.0 False True 3820445.913266989 2416320.245143037 4611830.399018098 1.0 0.6324707377094528 1.2071445333129633 21.865309605311452 -6.733959266359778 1.7087065997181112 0.7798015014168226 1.2070620308108408 0.5775233784210192 0.1544589396536424 0.3288834792176624 1.8828909855842928 0.07158193626078073 0.17684101882053976 1.8451884762225326e-07 6.733959266359778 0.42726052939401826 LPLAQVSAHPWVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPLAQVSAHPWVR 13 0 Q96GD4-5;Q96GD4;Q96GD4-4;J3KT86;Q96GD4-2 Q96GD4-5 AURKB Aurora kinase B 0 13776800.0 4703400.0 4651300.0 4422100.0 False True 6442374.084605766 4445790.18620778 3377691.056008283 1.0 0.6900856932277684 0.5242929099816434 22.619161004390822 -13.999999999999998 0.07745321983887549 2.6981600051589023 0.004998252994549374 0.9998969800918398 0.002001091219280256 12.283965349734729 0.07755720832777144 3.6175284503876686 0.47315126220142173 1.0000000000000041e-14 13.999999999999998 -2.693161752164353 LPLAQVSAHPWVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPLAQVSAHPWVR 13 0 Q96GD4-5;Q96GD4;Q96GD4-4;J3KT86;Q96GD4-2 Q96GD4-5 AURKB Aurora kinase B 0 7805200.0 3945700.0 1853100.0 2006400.0 False True 3281024.3741477663 1843116.9824884473 2425928.9634545604 1.0 0.561750469460377 0.7393815731968423 21.64571488074573 -10.155520097092321 5.296394863863903 1.0000117670097346 0.6505660213284534 0.8376564728601581 0.07251759443416786 1.0076418113599927e-05 1.6066530037116198e-06 0.0702172215371102 0.02340495296246741 6.990043894000525e-11 10.155520097092321 -0.3494457456812812 LPLFPEPLHVFAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPLFPEPLHVFAPR 14 0 P26358;P26358-2;P26358-3;K7ENW7 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 0 3509920.0 872020.0 1397700.0 1240200.0 False True 1143226.6646536915 1189168.6081919272 1111876.0008384367 1.0 1.040186207126434 0.9725770358717519 20.124680040726226 -6.745673934087263 1.6657267076590483 1.0237520888984046 0.9724847595227241 0.6301962563668464 0.016884179918788836 0.3076550081052318 1.6780829040790073 0.008011752803957746 0.019540511940908008 1.796081608951936e-07 6.745673934087263 -0.05126732937568057 LPLFPEPLHVFAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPLFPEPLHVFAPR 14 0 P26358;P26358-2;P26358-3;K7ENW7 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 0 2891640.0 0.0 967740.0 1923900.0 False True 0.0 1354163.6286974314 1419972.8742371637 0.0 LPLGFTFSFPCHQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPLGFTFSFPCHQTK 15 0 E9PB90;P52789 E9PB90 HK2 Hexokinase;Hexokinase-2 0 21520100.0 5643200.0 9663600.0 6213300.0 False True 7398289.8488265425 8221828.548417771 5570407.318182114 1.0 1.1113147384624098 0.7529317493644355 22.81876039253185 -6.823273721096668 1.3577025932404887 1.0598065419525702 0.7445478641298303 0.8917413040747278 0.04927745203634903 0.18925820668038454 0.6846071820577063 0.028515045782273103 0.06567057412263212 1.502194885127888e-07 6.823273721096668 -0.31525867782273986 LPLGFTFSFPCHQTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPLGFTFSFPCHQTK 15 0 E9PB90;P52789 E9PB90 HK2 Hexokinase;Hexokinase-2 0 32409300.0 9575500.0 8286800.0 14547000.0 False True 14526733.562819669 6807955.79493608 11671779.073823411 1.0 0.46865014529905386 0.8034689301176867 23.79220700362428 -10.097761336825343 5.406662994490746 1.0000048187006723 0.6360595377081777 0.6117047576114798 0.13668919651807107 7.939580615240221e-06 1.3248538512957708e-06 0.13235049622562234 0.044116248476649016 7.984333395963974e-11 10.097761336825343 -0.36394528099249457 LPLGFTFSFPCHQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPLGFTFSFPCHQTK 15 0 E9PB90;P52789 E9PB90 HK2 Hexokinase;Hexokinase-2 0 24516500.0 5643200.0 5801300.0 13072000.0 False True 7729643.541745818 5544979.3836663375 9984662.826290747 1.0 0.7173654714760557 1.2917365170031645 22.88197045405474 -6.7728696868861284 1.5632225978521963 0.8384892229259671 1.2953449590359358 0.7415408012280478 0.11921505023282515 0.2617929160029109 1.262875589050852 0.06009516568489738 0.1426926270816701 1.6870591634175888e-07 6.7728696868861284 0.45685573610996877 LPLGFTFSFPCHQTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPLGFTFSFPCHQTK 15 0 E9PB90;P52789 E9PB90 HK2 Hexokinase;Hexokinase-2 0 24820800.0 9575500.0 8940600.0 6304700.0 False True 12395673.511323633 8443047.750580972 5157309.291684903 1.0 0.6811286004643573 0.41605720632877463 23.56333332571673 -7.356234737086012 0.19701714804207582 1.1912894675037755 3.066689489833059e-15 0.9999737517471782 0.0012230763839360167 0.11484893265479765 0.013752193256910768 0.022777405676941347 0.05232851963674495 4.403168070118584e-08 7.356234737086012 -1.1912894675037724 down LPLGSLMK(ub)SPHLESLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPLGSLMKSPHLESLK 16 1 Q5VWM4;Q5VXH5 Q5VWM4 PRAMEF8;PRAMEF7 PRAME family member 8;PRAME family member 7 1 19905000.0 1263700.0 3996300.0 14645000.0 True False 1223584.5352144074 5592043.430429183 10809035.159417458 1.0 4.570214210372719 8.833909589682255 20.222682347342673 -6.968768267838944 0.28607892306810545 0.12684919726550675 13.408289602452301 0.9999711180533338 0.01721006888482258 0.07670441050349266 0.010453737435808744 0.07609846404026234 0.38843957530978623 1.0745626277703264e-07 6.968768267838944 13.281440405186794 LPLGSLMK(ub)SPHLESLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPLGSLMKSPHLESLK 16 1 Q5VWM4;Q5VXH5 Q5VWM4 PRAMEF8;PRAMEF7 PRAME family member 8;PRAME family member 7 1 15273900.0 1263700.0 3879200.0 10131000.0 True False 1050822.5414021662 3858301.9796390883 12249345.25954854 1.0 3.671697006509547 11.656911397431209 20.00308762277695 -6.951534610158663 0.5417345394022011 0.8837597383659876 14.814703625247985 0.9993162743658209 0.11838158972802086 0.08287531812230237 0.03345695253716437 0.12989834552140797 0.6614745270584205 1.118060719604854e-07 6.951534610158663 13.930943886881996 LPLISGFYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPLISGFYK 9 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 6442500.0 1243700.0 1335100.0 3863700.0 False True 1630502.7440079309 1135908.28417904 3463921.3872274393 1.0 0.6966613753662686 2.124449897405748 20.636885438354927 -6.851176201834544 1.2294679071203714 0.8379604108506209 2.1828163524317987 0.9419969746266958 0.14791860535450427 0.15616161956974303 0.45366345918034523 0.09411722008462699 0.21795390091286715 1.4087171381433553e-07 6.851176201834544 1.3448559415811778 up LPLISGFYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPLISGFYK 9 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 4717300.0 1243700.0 1371900.0 2101700.0 False True 1703529.4997287455 1311284.9217333763 1605321.7458702007 1.0 0.7697459433148491 0.9423504237090214 20.70009549987782 -10.48188833318813 4.951954545279822 1.0003913377341045 0.8560481835119266 0.4811673794313298 0.0704654840473544 0.00030526501248860546 3.1939195255885584e-05 0.06841204201586912 0.022742637183149693 3.29694473093247e-11 10.48188833318813 -0.14434315422217792 LPLPYGFSAMQGWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPLPYGFSAMQGWR 14 0 O15355 O15355 PPM1G Protein phosphatase 1G 0 5369400.0 1471600.0 2122600.0 1775200.0 False True 1929281.850994671 1805916.3538299978 1591519.3329208153 1.0 0.9360562599492293 0.8249283701602661 20.87963249307857 -6.962696572081588 0.39560817140735277 1.0064127594102468 0.750542871663542 0.9998574859899804 0.0008634839259713193 0.07875167631446289 0.017673122353013996 0.001431267018854878 0.009326404531120214 1.0896911604350144e-07 6.962696572081588 -0.2558698877467047 LPLPYGFSAMQGWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPLPYGFSAMQGWR 14 0 O15355 O15355 PPM1G Protein phosphatase 1G 0 7182900.0 3567700.0 1380200.0 2235000.0 False True 3454445.3163602473 1931321.0576479142 1649586.451437216 1.0 0.559082828291182 0.47752570973544645 21.72002264359024 -13.999999999999998 0.2373230502533718 3.8810539813120575 0.44053741260823875 0.9995206218505845 0.005024866949264583 13.53048703613524 0.1542015091066712 18.445639071969296 0.04048867830386312 1.0000000000000041e-14 13.999999999999998 -3.440516568703819 LPLPYGFSAMQGWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPLPYGFSAMQGWR 14 0 O15355 O15355 PPM1G Protein phosphatase 1G 0 10179400.0 1471600.0 2979700.0 5728100.0 False True 2015690.2884946717 2848047.001449775 4375240.753922589 1.0 1.4129387920882983 2.1705917714124836 20.942842554601462 -6.9616953862107955 0.41084226992460204 0.9630185222594404 2.6486679138043847 0.9998280010719592 0.006357411986637104 0.07910096136559414 0.018933911558570896 0.009758525351822237 0.06324120663322176 1.0922061403307101e-07 6.9616953862107955 1.6856493915449442 up LPLQDVYK(ub)IGGIGTVPVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPLQDVYKIGGIGTVPVGR 19 1 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 1 283030500.0 76016600.0 92899700.0 114114200.0 True False 99658498.7458016 79039426.88019435 102306757.24470045 1.0 0.7931027245533749 1.0265733332553377 26.57048950565923 -6.672860584371065 1.9274142955903224 0.8682644602551961 1.0256390925238832 0.29174854803690875 0.08782787557343694 0.4545531352348799 3.2582489075417866 0.03665080183564981 0.09755150175523704 2.1239261675987326e-07 6.672860584371065 0.1573746322686871 LPLQDVYK(ub)IGGIGTVPVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPLQDVYKIGGIGTVPVGR 19 1 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 1 346665200.0 139017300.0 104012500.0 103635400.0 True False 134604271.90572265 145545233.66802186 76490179.74464266 1.0 1.081282425939366 0.5682596745385368 27.004148956264086 -6.866357815883983 1.1531035944959653 1.0451036998720797 0.5402124782434811 0.9609155936071787 0.04451000177637371 0.14039959495010534 0.3511828629224358 0.030016922131635405 0.07065466679396971 1.3603234480787786e-07 6.866357815883983 -0.5048912216285987 LPLQDVYK(ub)IGGIGTVPVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPLQDVYKIGGIGTVPVGR 19 1 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 1 1121007000.0 196732000.0 206033000.0 718242000.0 True False 298456827.035731 169264801.40682352 576281153.8833487 1.0 0.5671332872092729 1.9308693977851503 28.152947014119462 -6.821345707481588 1.3660514701655675 0.7669947629160292 1.9615046586031346 0.8874366524597359 0.19089618443655978 0.19174766106778146 0.7027281661450746 0.1098028079605171 0.25299026686488996 1.5088785771140278e-07 6.821345707481588 1.1945098956871054 LPLQDVYK(ub)IGGIGTVPVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPLQDVYKIGGIGTVPVGR 19 1 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 1 255477800.0 76016600.0 86766100.0 92695100.0 True False 104121991.29137279 82932486.80487679 70802426.49550979 1.0 0.7964934763185643 0.6799949330336736 26.63369956718212 -13.999999999918364 0.06340548342692871 2.24999523699459 0.19307830424119898 0.9999450011905266 0.0009807007622285547 12.428888246731312 0.06568468672350072 2.4030861862142903 0.45355158970543663 1.0000000001879739e-14 13.999999999918364 -2.056916932753391 LPLQDVYK(ub)IGGIGTVPVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPLQDVYKIGGIGTVPVGR 19 1 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 1 371235500.0 139017300.0 156062300.0 76155900.0 True False 115599044.46060555 155221561.41395885 92079746.58490297 1.0 1.342758170175499 0.7965441843793302 26.784554231698362 -6.73706382235803 1.6973779422777182 1.2046324650685265 0.7964217305589839 0.5916862073577744 0.14402629069641545 0.32317130384383774 1.82701079375059 0.06715725808541075 0.16533636515300315 1.8320451718058772e-07 6.73706382235803 -0.4082107345095426 LPLQDVYK(ub)IGGIGTVPVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPLQDVYKIGGIGTVPVGR 19 1 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 1 870378900.0 196732000.0 201480900.0 472166000.0 True False 254673452.167482 190268310.79905474 386236632.8322828 1.0 0.7471069684716403 1.5165955836585603 27.92407333621191 -6.81815329183241 1.3797481242409484 0.8634285664791074 1.532751232136663 0.8800989346256245 0.11088598875140561 0.1958956487651824 0.7332614733976128 0.06316065446160662 0.14565860440396336 1.5200109205986188e-07 6.81815329183241 0.6693226656575556 LPLQLDDAVRPEAEGEEEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPLQLDDAVRPEAEGEEEGR 20 1 P14868;P14868-2;C9J7S3;C9JLC1 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 4556400.0 4556400.0 0.0 0.0 False True 4411759.576047265 0.0 0.0 1.0 0.0 0.0 22.072922741056875 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 LPNFGFVVFDDSEPVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPNFGFVVFDDSEPVQK 17 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 10087800.0 2121600.0 4937400.0 3028800.0 False True 2781438.1456036237 4200759.165834464 2715408.8303011274 1.0 1.5102831506335084 0.9762607284987218 21.407399592218184 -8.778640146991696 18.629058064984807 0.9999982561179438 1.2432719395661214 0.2167285338663515 0.21801374090822317 0.0 0.0 0.21109089694443112 0.07036363231481035 1.6647915122502424e-09 8.778640146991696 0.24327368344817757 LPNFGFVVFDDSEPVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPNFGFVVFDDSEPVQK 17 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 30891200.0 12089000.0 7223200.0 11579000.0 False True 11705241.31218404 10107461.428490384 8546112.537445879 1.0 0.8634987659732808 0.7301098977387327 23.48065134119052 -6.971408309405137 0.2219906198272688 1.059987596156552 0.5298457913039718 0.9999913781571214 0.00032348328904943197 0.07584836743345784 0.007373404353319407 0.0036391016079351753 0.013463242024702816 1.0680502612724917e-07 6.971408309405137 -0.5301418048525801 LPNFGFVVFDDSEPVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPNFGFVVFDDSEPVQK 17 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 70065000.0 14882000.0 33452000.0 21731000.0 False True 22577082.019934446 27482229.23833107 17435858.324964363 1.0 1.2172622314108448 0.7722813032069141 24.42835570092459 -6.773916111906772 1.5592534488316723 1.1239889375540941 0.7693860075448953 0.745403302352333 0.09167103186557071 0.26013430929594195 1.2486411137206417 0.046324627651394536 0.10989003128352863 1.6829991168980414e-07 6.773916111906772 -0.35460293000919885 LPNFGFVVFDDSEPVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPNFGFVVFDDSEPVQK 17 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 11275300.0 2121600.0 5080900.0 4072800.0 False True 2906012.8540841904 4856409.037710558 3110888.5219489723 1.0 1.6711588288005081 1.0705006062092408 21.470609653741075 -10.232736053207718 4.109422068185554 0.9997433684598713 1.3708297175349262 0.3369570792292127 0.24521769263844667 172935981.1017389 196.55455465325662 426619.19297353725 0.08394453858182944 5.851456041608134e-11 10.232736053207718 0.3710863490750549 LPNFGFVVFDDSEPVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPNFGFVVFDDSEPVQK 17 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 21488100.0 12089000.0 4896500.0 4502600.0 False True 10052539.13350541 4870121.582620842 5444072.8423298 1.0 0.4844668116126585 0.5415619645970384 23.261056616624796 -10.092217945345514 4.864960160229879 1.0000179370872555 0.5130143881041115 0.9897959358851365 0.02330899861668771 4.720783351152908e-06 8.808885491871352e-07 0.02256970515999784 0.007522946952474552 8.086899662150444e-11 10.092217945345514 -0.487003548983144 LPNFGFVVFDDSEPVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPNFGFVVFDDSEPVQK 17 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 43857000.0 14882000.0 15567000.0 13408000.0 False True 19265042.368076682 14700682.765507206 10967881.57769778 1.0 0.7630755481683814 0.5693152066912768 24.19948202301704 -6.973421620178307 0.15612763265612647 1.206839411828797 0.12042802038473435 0.9999982621647103 0.00023210245125385745 0.07520724379521819 0.00480079612515067 0.009309391004166508 0.023592471062998336 1.0631104321036512e-07 6.973421620178307 -1.0864113914440627 LPNFGFVVFDDSEPVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPNFGFVVFDDSEPVQR 17 0 Q9UN86-2;Q9UN86 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 4667000.0 1259100.0 2025200.0 1382700.0 False True 1650692.2931417457 1723048.0541677703 1239631.4677949601 1.0 1.0438335850519485 0.7509767101629718 20.654639780712664 -6.868800150224846 1.140485432934096 1.024617480985335 0.7342166506229003 0.9634677464157854 0.02465054954170488 0.13800723134753162 0.33625506980326253 0.016786756961008665 0.03966088205819077 1.352694891108367e-07 6.868800150224846 -0.2904008303624347 LPNFGFVVFDDSEPVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPNFGFVVFDDSEPVQR 17 0 Q9UN86-2;Q9UN86 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 16085100.0 6387000.0 3923600.0 5774500.0 False True 6184248.181067037 5490313.941303697 4261985.218713292 1.0 0.8877900402044331 0.6891678816774013 22.56016678677744 -6.962360767551525 0.40077635293318803 1.010825456066437 0.5588708997321065 0.9998479825676507 0.0015845915984310252 0.07886834183981134 0.018092644030198817 0.002555452655318881 0.016636491721729207 1.0905340556341755e-07 6.962360767551525 -0.45195455633433046 LPNFGFVVFDDSEPVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPNFGFVVFDDSEPVQR 17 0 Q9UN86-2;Q9UN86 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 36136300.0 8380300.0 13088000.0 14668000.0 False True 12713527.781995488 10752344.142989252 11768863.370787222 1.0 0.8457404056029512 0.9256961224762437 23.599861072791963 -10.155263605294069 4.622892965697599 1.0000142184028833 0.8857182640381126 0.7314653100053443 0.032641784731408906 4.784032683537751e-06 8.741994303141531e-07 0.031609203408289 0.01053509072055319 6.99417339262899e-11 10.155263605294069 -0.11429595436477069 LPNFGFVVFDDSEPVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPNFGFVVFDDSEPVQR 17 0 Q9UN86-2;Q9UN86 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 6338600.0 1259100.0 1865700.0 3213800.0 False True 1724623.2958981004 1783267.2049551439 2454766.63028865 1.0 1.034003894761554 1.4233639520741403 20.717849842235555 -6.924078853010951 0.7938674036052733 0.9926056339422734 1.492451338592211 0.9952415762655875 0.013248775505935995 0.09583017977072461 0.09360340132181243 0.011669257923875544 0.03644411051852707 1.1910257388919743e-07 6.924078853010951 0.4998457046499375 LPNGLVIASLENYSPVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPNGLVIASLENYSPVSR 18 0 P22695;H3BRG4;H3BSJ9;H3BP04;H3BUE4;H3BUI9 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 16145800.0 7778000.0 3616900.0 4750900.0 False True 7531091.647461946 5061147.031884324 3506496.7660550675 1.0 0.6720336531278279 0.465602721384594 22.8444275710382 -8.826266917761918 0.1261786905912513 1.5314452731030612 3.0575500414353575e-05 0.9999286135560741 0.0018591150470338154 0.3415396339536684 0.03716813077654007 0.24345643038926304 0.17835476235353842 1.4918772187336025e-09 8.826266917761918 -1.5314146976026468 LPNGLVIASLENYSPVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPNGLVIASLENYSPVSR 18 0 P22695;H3BRG4;H3BSJ9;H3BP04;H3BUE4;H3BUI9 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 7973300.0 1489800.0 1547500.0 4936000.0 False True 2040619.3203311793 1479126.3331018304 3770218.4601110104 1.0 0.7248418744079017 1.8475853984853619 20.960575640526486 -6.841894109670412 1.2734614893649068 0.8536313654535066 1.885943407329492 0.9276722972493647 0.1284995776303845 0.1666038447500371 0.5239936847600024 0.07909421874862169 0.18233196338182156 1.4391494310463256e-07 6.841894109670412 1.0323120418759855 LPNLTHLNLSGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPNLTHLNLSGNK 13 0 Q92688-2;Q92688 Q92688-2 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B 0 44984000.0 10518000.0 13064000.0 21402000.0 False True 13789199.856456878 11114902.123073157 19187526.342480447 1.0 0.8060585268744608 1.391489465829721 23.717035408473652 -6.8174129072389755 1.3829592657163094 0.8951837979045203 1.403581509699585 0.8783404930010636 0.0849302494830659 0.1968680910768808 0.740528752315522 0.04826662541800311 0.11133468705122182 1.5226044430669915e-07 6.8174129072389755 0.5083977117950647 LPNLTHLNLSGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPNLTHLNLSGNK 13 0 Q92688-2;Q92688 Q92688-2 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B 0 35842400.0 10929000.0 6432400.0 18481000.0 False True 10582064.877232144 9000890.864522874 13640271.681884214 1.0 0.8505798224587295 1.2889990602147943 23.33511783206793 -6.81472333661991 1.3943714253201902 0.9190038282727286 1.297540672566756 0.8718216435786654 0.06515334003164118 0.20045118213595733 0.7671436465119222 0.03672899621351692 0.08480349297647921 1.532063137870943e-07 6.81472333661991 0.37853684429402734 LPNLTHLNLSGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPNLTHLNLSGNK 13 0 Q92688-2;Q92688 Q92688-2 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B 0 36174000.0 10518000.0 11208000.0 14448000.0 False True 14406788.8382624 10712793.500100357 11035679.965900298 1.0 0.7435934280961132 0.7660055332102244 23.780245469996544 -10.754798748014885 6.900551451596065 1.0049830762035998 0.7547994806531838 0.993773109805993 0.00914970359853229 0.0007112458276251393 2.5273085835933403e-05 0.00898301628053898 0.002953054138320798 1.758738424223374e-11 10.754798748014885 -0.250183595550416 LPNLTHLNLSGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPNLTHLNLSGNK 13 0 Q92688-2;Q92688 Q92688-2 ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member B 0 29099100.0 10929000.0 10297000.0 7873100.0 False True 9087947.736792179 10241528.017205518 9519328.808898585 1.0 1.1269351798473837 1.047467380381159 23.115523107502206 -10.295317597718633 3.881217717699075 0.9998396574671081 1.0872012801156494 0.6161920188641654 0.03244259332316838 4.514184055671802e-05 8.19601212120037e-06 0.03147016463064299 0.010470801980650198 5.066200836476789e-11 10.295317597718633 0.0873616226485413 LPNNHIGISFIPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPNNHIGISFIPR 13 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 23479500.0 6517900.0 7771700.0 9189900.0 False True 8545030.019433385 6612192.653849321 8239017.303745501 1.0 0.7738056670148212 0.964188222277518 23.0266541295476 -10.089935055512209 6.159014956772458 1.0000003252204173 0.8689969447294182 0.3869982466368449 0.07772335272014505 3.4709075429936373e-07 5.1253859472985244e-08 0.07525549938461276 0.02508510422470951 8.129520760985647e-11 10.089935055512209 -0.13100338049099902 LPNNHIGISFIPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPNNHIGISFIPR 13 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 17040200.0 4593100.0 2547300.0 9899800.0 False True 4447294.554635825 3564450.173994016 7306745.392366057 1.0 0.8014873155362424 1.6429641218051463 22.084496530217613 -6.844502906348322 1.261260656032768 0.894372885302202 1.6732118273816907 0.9319296958850385 0.09370305580573005 0.1636056355759393 0.5035923595032421 0.058206668183145654 0.1343084649828813 1.4305304075150056e-07 6.844502906348322 0.7788389420794887 LPNNHIGISFIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPNNHIGISFIPR 13 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 19415600.0 6517900.0 3926800.0 8970900.0 False True 8927743.769624507 3753300.991808896 6852158.181484981 1.0 0.4204086820433867 0.7675128630817747 23.089864191070493 -10.365047315096064 6.0866031718313485 1.0000554450739292 0.5939607725626062 0.6459609150467109 0.14170468852178178 0.00010663085523917755 1.1123799324974401e-05 0.13722362645900246 0.04573499156036406 4.314720666647106e-11 10.365047315096064 -0.40609467251132303 LPNSK(ub)QSQDEPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPNSKQSQDEPLR 13 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A087WZC9 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 37524700.0 10612000.0 17935000.0 8977700.0 True False 13912434.766754188 15259167.910082456 8048773.7241793685 1.0 1.0968006798167698 0.5785309228125258 23.729871587221655 -6.858428460432993 1.1936023038727548 1.0523198273117358 0.5541716893705119 0.9517006289243853 0.04944770614917554 0.1484371573389966 0.4027350282271363 0.03233018007368501 0.07534219404538677 1.3853883765328402e-07 6.858428460432993 -0.4981481379412239 LPNSK(ub)QSQDEPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPNSKQSQDEPLR 13 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A087WZC9 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 44347000.0 11924000.0 14345000.0 18078000.0 True False 11545479.146867596 20073033.308186736 13342829.471625047 1.0 1.7386054794991121 1.1556756806619923 23.46082471159516 -10.088000528732575 4.366360896345014 0.9999604621127905 1.447140579482204 0.43961976085615506 0.23798009401001224 82728951.33271 4.0209320861169005 38753.53151282159 0.08146691605283815 8.16581377209564e-11 10.088000528732575 0.44718011736941354 LPNSK(ub)QSQDEPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPNSKQSQDEPLR 13 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A087WZC9 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 370601000.0 51943000.0 73428000.0 245230000.0 True False 78801328.5419605 60324199.70441749 196760183.01187292 1.0 0.765522622785424 2.4969145400524706 26.2317166170498 -6.872727089475673 1.119635846336755 0.8649433238614945 2.6036803200376237 0.967326654967469 0.1386260928368284 0.13426353900416144 0.31292448944120377 0.09592513656080814 0.22823371134626078 1.3405188044264825e-07 6.872727089475673 1.7387369961761292 up LPNSK(ub)QSQDEPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPNSKQSQDEPLR 13 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A087WZC9 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 39232000.0 10612000.0 10405000.0 18215000.0 True False 14535543.1785169 9945272.695266273 13912992.149700595 1.0 0.6842037186450032 0.9571704324241272 23.793081648744547 -10.154936354018451 7.122700761025268 1.0000001715836575 0.8206870762416729 0.36522599100116837 0.11143819425386604 3.035979400216807e-07 3.600448810559827e-08 0.10789967132334372 0.03596652253972085 6.999445655641982e-11 10.154936354018451 -0.17931309534198459 LPNSK(ub)QSQDEPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPNSKQSQDEPLR 13 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A087WZC9 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 48540000.0 11924000.0 19990000.0 16626000.0 True False 9915334.322766017 19882309.902295657 20102419.730061583 1.0 2.0052082214358675 2.027407152969678 23.241229987029435 -10.9842357304738 0.6532138202838826 4.401128360472507e-08 2.0240424881292354 0.9999513486046065 0.00334228626160953 2.9182354928730256 0.32790428093789403 4.40429826181001 0.003624795484855787 1.0369654091248345e-11 10.9842357304738 2.024042444117952 LPNSK(ub)QSQDEPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPNSKQSQDEPLR 13 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61;A0A087WZC9 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 563214000.0 51943000.0 63861000.0 447410000.0 True False 67241237.4496041 60307079.21166942 365985970.8142721 1.0 0.8968764035145593 5.442879766877743 26.002842939142248 -6.901710305033856 0.9503895218149623 0.8197609635660035 5.9369907393909855 0.9873982400550098 0.23788705226683995 0.11015736866700357 0.1704035750689706 0.18710836398353947 0.49113873671543357 1.2539773582478175e-07 6.901710305033856 5.117229775824982 up LPPNTNDEVDEDPTGNK(ub)ALWDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPPNTNDEVDEDPTGNKALWDR 22 1 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 1 44911000.0 15317000.0 19058000.0 10536000.0 True False 20080735.330038983 16214620.687502153 9445835.788448459 1.0 0.8074714606315503 0.4703929230279896 24.259308764056836 -6.9625614360195245 0.3976916642655308 1.0190080488690954 0.2465941053017468 0.9998537180705772 0.002647273109718815 0.07879850990909062 0.017841256529805564 0.004338953565243899 0.028266355200185014 1.0900302839816982e-07 6.9625614360195245 -0.7724139435673485 down LPPNTNDEVDEDPTGNK(ub)ALWDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPPNTNDEVDEDPTGNKALWDR 22 1 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 1 52038000.0 18062000.0 22357000.0 11619000.0 True False 17488631.696638957 31284266.690214816 8575635.337471606 1.0 1.7888344401596132 0.4903548480079039 24.059914082019095 -6.742246094329091 1.6783461459094935 1.4681222538222152 0.4891937383044902 0.6150493870656256 0.3314230840671586 0.3137608285223682 1.7361901848930694 0.15616087959279873 0.3822828319250739 1.810313981831944e-07 6.742246094329091 -0.978928515517725 LPPNTNDEVDEDPTGNK(ub)ALWDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPPNTNDEVDEDPTGNKALWDR 22 1 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 1 115442000.0 34117000.0 45523000.0 35802000.0 True False 51757983.28679643 37399064.97717754 28725719.00742595 1.0 0.7225757767636615 0.5550007396589183 25.62527806904543 -10.198652507942864 0.08732171288247692 1.850931437963599 4.912651718061901e-10 0.9999528786467937 0.0012596633341828403 1.9135271817524189 0.043484204423832565 0.6512502993052011 0.30203345840508516 6.329180655818604e-11 10.198652507942864 -1.8509314374723338 LPPNTNDEVDEDPTGNK(ub)ALWDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPPNTNDEVDEDPTGNKALWDR 22 1 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 1 45861000.0 15317000.0 18866000.0 11678000.0 True False 20980108.826361023 18032437.738480844 8919896.91595957 1.0 0.8595016302214553 0.4251597067386002 24.322518825579728 -6.95077360344848 0.5502835078535101 1.0059967440438922 0.25824985965059427 0.9992606131107429 0.006653374586797909 0.08317655042741345 0.03468798010142156 0.007218786712103824 0.03603428233041237 1.1200215955714577e-07 6.95077360344848 -0.747746884393298 down LPPNTNDEVDEDPTGNK(ub)ALWDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPPNTNDEVDEDPTGNKALWDR 22 1 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 1 47904700.0 18062000.0 22629000.0 7213700.0 True False 15019353.282271065 22507093.085495166 8722051.317619706 1.0 1.4985394285959486 0.5807208308972442 23.84031935745337 -6.759217275332425 1.6157019035080291 1.2898609088835258 0.5775282866129846 0.6876816099413927 0.20966171497459066 0.2842200917747913 1.462190844746124 0.10240082941343998 0.24624788969259595 1.7409356741702102e-07 6.759217275332425 -0.7123326222705412 LPPNTNDEVDEDPTGNK(ub)ALWDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPPNTNDEVDEDPTGNKALWDR 22 1 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 1 58010000.0 34117000.0 23893000.0 0.0 True False 44165129.04661155 22563333.54636498 0.0 1.0 0.5108857153468703 0.0 25.396404391137878 -7.895410942493597 0.5997076007163918 1.0089070404371805 3.204140156643101e-18 0.9887421709251701 0.04331975607049265 0.11334953018053587 0.160088144570237 0.04437927903651274 0.07730036088938275 1.2722986240566705e-08 7.895410942493597 -1.0089070404371805 down LPPVLVLHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPPVLVLHLK 10 0 Q14694;Q14694-3;Q14694-2;H3BQP1 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 0 21030600.0 2802400.0 8089200.0 10139000.0 False True 4251445.682882971 6645619.058791933 8135022.2059184285 1.0 1.5631433527537004 1.913471984052715 22.019522075250585 -8.969728445445066 0.11975100500769437 5.717544592725384e-20 2.752239387408454 0.9999309873975681 0.0031259111229040145 0.45628045280515084 0.03839076639440446 0.4953529473403476 0.3405600572914415 1.0721895116286195e-09 8.969728445445066 2.752239387408454 LPPVLVLHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPPVLVLHLK 10 0 Q14694;Q14694-3;Q14694-2;H3BQP1 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 0 13338300.0 2802400.0 4671500.0 5864400.0 False True 3627762.04356257 4411526.9184214715 4797139.373825394 1.0 1.2160463849192327 1.3223412440564764 21.790648397343034 -13.55781801456851 0.09631521683438043 6.941975965944904e-29 1.5674667911231284 0.999823323170595 0.001782628610162928 10.468037779755539 0.08756325219478041 2.179825084904824 0.21228164037036382 2.7681013391367336e-14 13.55781801456851 1.5674667911231284 LPPYLIFCIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPPYLIFCIK 10 0 A0A087X1B2;B9A018;Q53GS9;Q53GS9-2;Q53GS9-3 A0A087X1B2 USP39 U4/U6.U5 tri-snRNP-associated protein 2 0 3373170.0 835520.0 1788300.0 749350.0 False True 1095374.8111871898 1521492.6107388032 671814.4502727645 1.0 1.389015517975786 0.6133192432502973 20.062993179531077 -6.770368929111944 1.5730841616397433 1.22303104043037 0.6089027319861846 0.7319107051797851 0.16396700813609663 0.2658573760513323 1.2984247130503634 0.08215656499771107 0.1954971797980573 1.6968016228996394e-07 6.770368929111944 -0.6141283084441853 LPPYLIFCIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPPYLIFCIK 10 0 A0A087X1B2;B9A018;Q53GS9;Q53GS9-2;Q53GS9-3 A0A087X1B2 USP39 U4/U6.U5 tri-snRNP-associated protein 2 0 4226120.0 835520.0 1104900.0 2285700.0 False True 1144434.3230790086 1056081.8645843044 1745864.7354691545 1.0 0.9227981399081084 1.5255263672729125 20.126203241053968 -6.8747338728228 1.1088118401749676 0.954804816054844 1.5641419187075176 0.9691806493616573 0.04701229944317326 0.1323939009933148 0.3013828423940196 0.03280224903228874 0.07836176271639578 1.3343388384744302e-07 6.8747338728228 0.6093371026526736 LPPYSAGDGAELSTPGGK(ub)LPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPPYSAGDGAELSTPGGKLPR 21 1 Q8IUF8-4;Q8IUF8;Q8IUF8-3 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 1 11082600.0 3530600.0 4707700.0 2844300.0 True False 4628650.79037904 4005329.510470874 2549999.120452159 1.0 0.8653341312324142 0.5509162898511382 22.14216029160127 -6.956909398859381 0.4769987033268174 1.0077642443670647 0.39544354219030875 0.9996378471156728 0.0035809191002063637 0.08082416736303313 0.0253549835705153 0.004406568994875582 0.02593997116874518 1.1043089733171946e-07 6.956909398859381 -0.6123207021767559 LPPYSAGDGAELSTPGGK(ub)LPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPPYSAGDGAELSTPGGKLPR 21 1 Q8IUF8-4;Q8IUF8;Q8IUF8-3 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 1 6021400.0 3217900.0 2803500.0 0.0 True False 3115749.5258894074 3922952.1700593587 0.0 1.0 1.2590717377833929 0.0 21.571147829591037 -6.895326602753681 1.3079776623672286 1.134916780716215 2.2199790552742495e-19 0.9433664500706178 0.1291913670590487 0.13768943807287587 0.4730105514561811 0.0805374413359833 0.16133658816519206 1.2725457277144708e-07 6.895326602753681 -1.134916780716215 down LPPYSAGDGAELSTPGGK(ub)LPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPPYSAGDGAELSTPGGKLPR 21 1 Q8IUF8-4;Q8IUF8;Q8IUF8-3 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 1 7851700.0 3530600.0 0.0 4321100.0 True False 4835958.230877479 0.0 3300545.175847991 1.0 0.0 0.6825007616430779 22.205370353124163 -10.445828088634595 8.128475741256192 1.000020613295941 0.34125038388702883 0.5539990350808098 0.278629769181071 0.00010408776318257568 7.096474279082729e-06 0.2697905158493438 0.08992737131632542 3.582382142510046e-11 10.445828088634595 -0.6587702294089122 LPPYSAGDGAELSTPGGK(ub)LPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPPYSAGDGAELSTPGGKLPR 21 1 Q8IUF8-4;Q8IUF8;Q8IUF8-3 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 1 8244800.0 3217900.0 5026900.0 0.0 True False 2675826.427140961 4999819.091938476 0.0 1.0 1.8685139817834262 0.0 21.351553105025314 -6.788661029719187 1.5563875305372532 1.4911476254043448 1.5562669651094624e-18 0.7681409876697413 0.3676129889423245 0.2445798438884816 1.179085422379861 0.187529102225026 0.4295424670992689 1.6268180046864733e-07 6.788661029719187 -1.4911476254043448 LPQFGISTPGSDLHVNAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPQFGISTPGSDLHVNAK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 86244000.0 30248000.0 29722000.0 26274000.0 False True 39655420.92204864 25287593.455448613 23555418.518004417 1.0 0.6376831431232789 0.5940024836530601 25.241014760980192 -13.999999999945967 0.2984466624641481 4.275607437304808 0.5830809126585104 0.9996463625498606 0.003421973722360604 16.487963162384872 0.1734534629793284 33.32132081743149 0.015892115612585172 1.0000000001244161e-14 13.999999999945967 -3.692526524646298 LPQFGISTPGSDLHVNAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPQFGISTPGSDLHVNAK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 75700000.0 25022000.0 11708000.0 38970000.0 False True 24227690.30635031 16383065.456413427 28762587.925059628 1.0 0.6762124349971268 1.187178289030741 24.530153539392767 -6.73549970704813 1.7034889573811638 0.8063471207020564 1.1871753103941078 0.5844486982329906 0.13606352037408573 0.32601388376604246 1.8558024429600188 0.06323892248205773 0.15593689372339237 1.838655194122233e-07 6.73549970704813 0.38082818969205146 LPQFGISTPGSDLHVNAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPQFGISTPGSDLHVNAK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 92995000.0 18210000.0 51867000.0 22918000.0 False True 27625901.329324473 42610928.61127933 18388247.254683748 1.0 1.542426728573322 0.6656161924087126 24.719518199200085 -6.739371272504224 1.6890923320472557 1.3229760545104168 0.6651808662513184 0.6020919523619532 0.22790755924758946 0.31894706333994083 1.7865009916309484 0.10675512303338063 0.2621389784562079 1.8223371447347822e-07 6.739371272504224 -0.6577951882590983 LPQFGISTPGSDLHVNAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPQFGISTPGSDLHVNAK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 76416000.0 30248000.0 17385000.0 28783000.0 False True 41431503.021464266 16616873.215492949 21985048.20449256 1.0 0.4010685590354834 0.5306360281716753 25.304224822503084 -9.877520488702896 6.7481915591062664 1.000000014221795 0.4658522936041635 0.9577354688518986 0.052895697774626334 1.1357834207979873e-08 1.922594283336188e-09 0.05121604066812078 0.01707201304725548 1.3258045688270397e-10 9.877520488702896 -0.5341477206176315 LPQFGISTPGSDLHVNAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPQFGISTPGSDLHVNAK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 55491000.0 25022000.0 12162000.0 18307000.0 False True 20806901.66255044 12096480.892032003 22134909.057995718 1.0 0.5813686770002862 1.0638253314685246 24.310558814827044 -6.677286121774212 1.9116632613654638 0.7344790448262956 1.0619450653823266 0.3116503224346163 0.17753316182960596 0.44460360835274876 3.1389930615554746 0.07458569187679295 0.1973917078354765 2.1023928854837976e-07 6.677286121774212 0.327466020556031 LPQFGISTPGSDLHVNAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPQFGISTPGSDLHVNAK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 63012000.0 18210000.0 25106000.0 19696000.0 False True 23573203.9727642 23708829.030052293 16111530.098026214 1.0 1.005753356966019 0.6834679798571721 24.490644521292534 -6.902836164446125 0.9431566236634783 1.0123767801095773 0.6476198048186205 0.9879254674494462 0.016547350019156276 0.10934785853717625 0.165876742677014 0.013084948490164863 0.034556042267528404 1.2507307735416045e-07 6.902836164446125 -0.36475697529095685 LPSLGAGFSQGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPSLGAGFSQGLK 13 0 C9JFV4;Q8IZL8;E7EV54 C9JFV4 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 0 9542600.0 2229400.0 2437100.0 4876100.0 False True 2922764.9895403087 2073494.1797413977 4371567.946853982 1.0 0.7094289780949908 1.495696014732112 21.478902400501905 -6.8066377130384526 1.428434566598583 0.8409976063161398 1.508442567183268 0.8509104928377372 0.12533989771001258 0.21142256388854158 0.8508122515522247 0.06900504067715478 0.15989330721194633 1.560854018939998e-07 6.8066377130384526 0.6674449608671281 LPSLGAGFSQGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPSLGAGFSQGLK 13 0 C9JFV4;Q8IZL8;E7EV54 C9JFV4 PELP1 Proline-, glutamic acid- and leucine-rich protein 1 0 6026800.0 2229400.0 1431100.0 2366300.0 False True 3053669.4272696525 1367869.2699851547 1807428.6754782612 1.0 0.4479428119395996 0.591887471295254 21.542112462024797 -10.35341864987319 8.776125392246687 1.0000010158720316 0.5199151416175285 0.9368345953620814 0.058765161103349 1.1680726314889547e-06 8.598341791898113e-08 0.056899242945200094 0.01896637419087221 4.431812214664745e-11 10.35341864987319 -0.4800858742545031 LPTFGAPEQLVDLK(ub)QAGLEAAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPTFGAPEQLVDLKQAGLEAAAK 23 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 68068000.0 32861000.0 14325000.0 20882000.0 True False 31817845.542202003 20045047.203888126 15412377.753428172 1.0 0.6299938560359507 0.48439413451126884 24.923332815065567 -13.999999999999998 0.12885985399759492 2.758183933597552 0.2775082152329434 0.9996508078017095 0.004055734785591934 11.938615023735405 0.11151698798626486 5.321947980567296 0.183915503791428 1.0000000000000041e-14 13.999999999999998 -2.4806757183646084 LPTFGAPEQLVDLK(ub)QAGLEAAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPTFGAPEQLVDLKQAGLEAAAK 23 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 70445000.0 11357000.0 11704000.0 47384000.0 True False 17229399.307915326 9615329.756230608 38018531.630855046 1.0 0.5580769000932753 2.2066080744549823 24.038369068003156 -6.835360901362371 1.3037667319739032 0.7645936594309333 2.2560348744489067 0.9161797214030472 0.20171447584988053 0.17428754223706353 0.5774701644496774 0.12140304149221012 0.27943638806868676 1.46096260103865e-07 6.835360901362371 1.4914412150179734 up LPTFGAPEQLVDLK(ub)QAGLEAAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPTFGAPEQLVDLKQAGLEAAAK 23 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 72418000.0 32861000.0 19224000.0 20333000.0 True False 27325377.489132393 19120436.496334746 24584536.290830165 1.0 0.6997318336750941 0.8996961268186582 24.703738090499844 -10.220087154704753 4.907691928550788 1.0000297904917006 0.7997139811080118 0.572215798043426 0.08163508083071506 2.6613329948444808e-05 4.229279335718268e-06 0.07905457477177487 0.0263476090434896 6.024386758719813e-11 10.220087154704753 -0.20031580938368876 LPTFGAPEQLVDLK(ub)QAGLEAAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPTFGAPEQLVDLKQAGLEAAAK 23 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 64351000.0 11357000.0 19046000.0 33948000.0 True False 14701860.379938664 17986073.35722044 27769812.335895285 1.0 1.2233875776539975 1.8888638320758655 23.809495390095606 -6.951608436646868 0.5408988526650579 0.9902599800781637 2.1527704426532943 0.9993215289749738 0.009834006622063832 0.08284626238184056 0.033338799771862694 0.01080298700512016 0.05511880195473163 1.1178706746363062e-07 6.951608436646868 1.1625104625751306 LPTSHTCFNVLLLPEYSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPTSHTCFNVLLLPEYSSK 19 0 Q05086-2;Q05086-3;Q05086;A0A0D9SG63;S4R306;A0A1B0GTB3 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 0 6721700.0 1510600.0 3689500.0 1521600.0 False True 1980411.228671211 3139040.9815583616 1364159.428217842 1.0 1.58504503312908 0.688826344987524 20.91736860365122 -6.730565750108166 1.7212237606799423 1.3518593744626397 0.6893109710156992 0.5618442742200617 0.2459284643726428 0.3351876216222361 1.945708145649123 0.11321608371777774 0.2807521950696797 1.859662997822602e-07 6.730565750108166 -0.6625484034469405 LPTSHTCFNVLLLPEYSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPTSHTCFNVLLLPEYSSK 19 0 Q05086-2;Q05086-3;Q05086;A0A0D9SG63;S4R306;A0A1B0GTB3 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 0 32522800.0 5519800.0 16343000.0 10660000.0 False True 8373940.15143356 13426463.961558184 8553046.32755603 1.0 1.6033627800957793 1.0213885187717529 22.99747517649499 -10.320091418856144 5.877310594870231 0.9999684766571196 1.3123756494337597 0.27752787963029557 0.23758999727950625 9.815116466433405e-05 1.1354097177893638e-05 0.23006869632994967 0.076681841890749 4.7852935143734144e-11 10.320091418856144 0.3124071727766401 LPTSHTCFNVLLLPEYSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPTSHTCFNVLLLPEYSSK 19 0 Q05086-2;Q05086-3;Q05086;A0A0D9SG63;S4R306;A0A1B0GTB3 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 0 8512200.0 1510600.0 2153100.0 4848500.0 False True 2069109.6424300459 2057968.9226504357 3703384.157991946 1.0 0.9946156938466895 1.7898443282312204 20.98057866517411 -6.905375441169584 0.9266624587372834 0.9716339098985233 1.8830600954943373 0.989055871106177 0.03908509007751678 0.10755622893485418 0.15594756056889847 0.03128503259713842 0.08382830826431602 1.2434392121585917e-07 6.905375441169584 0.911426185595814 LPVDIAYK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPVDIAYKR 9 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 6923800.0 1855900.0 2102800.0 2965100.0 True False 1796985.4703682996 2942459.0059571364 2188451.3589067073 1.0 1.637441734770436 1.2178458841173463 20.77714731322359 -10.144167095457998 4.184543212037172 0.9998899960570105 1.4276438094890305 0.5807077259126951 0.17129928890545223 24150544.86391863 19515269.224716146 21784.552048282214 0.05864030333796658 7.175181719554957e-11 10.144167095457998 0.42775381343202 LPVDIAYK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPVDIAYKR 9 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 6207900.0 1855900.0 2110800.0 2241200.0 True False 1543263.080310423 2099428.7014390044 2709824.5578620196 1.0 1.360382897915701 1.7559057768147646 20.557552588657867 -6.9699300086439635 0.2598517446841792 0.8887554537058882 2.239265530049825 0.9999818316498269 0.0013158366280743847 0.07632541755321971 0.009111341785291206 0.008264548282056524 0.03732650321745638 1.0716920063331712e-07 6.9699300086439635 1.3505100763439368 LPVDIAYK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPVDIAYKR 9 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 12011900.0 2654500.0 3610300.0 5747100.0 True False 3436302.5780177102 3409383.6312912405 4701186.770225756 1.0 0.9921663048828493 1.3680945328562177 21.712425645552063 -6.902142023108118 0.9476220214184898 0.9852752376868327 1.4093176343956584 0.9876021136415035 0.019529718359031577 0.10984638642733877 0.168659585199875 0.015392366386673828 0.04049655909290363 1.2527314393485333e-07 6.902142023108118 0.4240423967088257 LPVGK(ub)EEEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPVGKEEEVK 10 1 Q8WUX2 Q8WUX2 CHAC2 Putative glutathione-specific gamma-glutamylcyclotransferase 2 1 7691800.0 1104700.0 2275800.0 4311300.0 True False 1675910.664387958 1869665.7090934431 3459169.665290079 1.0 1.115611797706559 2.0640537343637986 20.676513816524007 -6.929630547568497 0.7498165023515246 0.9853782800238329 2.2569461495325736 0.9964652352130705 0.028341200314859573 0.09282978671422007 0.07862247889628354 0.025763836607406915 0.08599238102308913 1.1758974604393811e-07 6.929630547568497 1.2715678695087407 up LPVGK(ub)EEEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPVGKEEEVK 10 1 Q8WUX2 Q8WUX2 CHAC2 Putative glutathione-specific gamma-glutamylcyclotransferase 2 1 2052420.0 568210.0 721510.0 762700.0 True False 472491.79097105697 717623.082421478 922177.0436736408 1.0 1.5188053975427414 1.9517313555403757 18.849929738737238 -6.973208580381452 0.16436712582471286 0.5872055673912795 2.8948639079782117 0.9999978167443292 0.0005748542054065505 0.07527462603033619 0.005096630939030872 0.019225153027605534 0.05113885050549091 1.0636320606280845e-07 6.973208580381452 2.307658340586932 LPVPAAAPTPWETHK(ub)GALP ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPVPAAAPTPWETHKGALP 19 1 Q12788;J3KNP2 Q12788 TBL3 Transducin beta-like protein 3 1 6676100.0 1065000.0 1433500.0 4177600.0 True False 1031192.1579515255 2005904.0256037426 3083361.234686404 1.0 1.945228161537315 2.9900937579001132 19.97588176671719 -6.969834341335863 0.2621155224260955 0.7141271103399908 4.252280193491468 0.9999810607248987 0.0035372061662866617 0.07635652574271688 0.009222445783645495 0.02151740342037539 0.09827526319425404 1.0719281069210681e-07 6.969834341335863 3.538153083151477 LPVPAVK(ub)DTVNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LPVPAVKDTVNR 12 1 P50416;P50416-2 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 1 7368700.0 1475300.0 2083500.0 3809900.0 True False 1934132.5868255228 1772649.9214193916 3415688.0951414006 1.0 0.9165089991730239 1.7660051427743864 20.883255265793125 -6.882749343420463 1.0643907629154585 0.9461109015074756 1.8294639376283122 0.9758345114343632 0.05942947225691683 0.1252206219322416 0.2578292844393861 0.042899818295190975 0.10450283023526055 1.3099377460489427e-07 6.882749343420463 0.8833530361208366 LPVPAVK(ub)DTVNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LPVPAVKDTVNR 12 1 P50416;P50416-2 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 1 6890200.0 1217000.0 2076800.0 3596400.0 True False 1178367.0011521191 2906077.0703689246 2654394.9503126633 1.0 2.466190132214819 2.2526046195433125 20.16835750431772 -9.907200227570163 6.885692630474759 0.9999999594150342 2.359397375879077 0.9818220553140793 0.08719592041603134 5.422241770951599e-08 8.76991827342296e-09 0.0844270894231985 0.028142362302370296 1.2382255821290327e-10 9.907200227570163 1.359397416464043 LPVPAVK(ub)DTVNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LPVPAVKDTVNR 12 1 P50416;P50416-2 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 1 33380600.0 4258500.0 9820100.0 19302000.0 True False 6460455.838052076 8067626.430208492 15486951.23963287 1.0 1.2487704633301853 2.3971917195710475 22.623204531781433 -6.941600329369893 0.6445022114085547 0.9873810116251784 2.7220317666476954 0.9983661048997972 0.02459813294197104 0.08704405190184676 0.05134120585483258 0.024245442394994373 0.09816640330079938 1.1439305819795003e-07 6.941600329369893 1.734650755022517 up LPVPAVK(ub)DTVNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LPVPAVKDTVNR 12 1 P50416;P50416-2 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 1 8878300.0 1475300.0 2422400.0 4980600.0 True False 2020758.278483413 2315370.3581944276 3804284.8586768466 1.0 1.1457928357131968 1.8826026344585745 20.946465327316016 -6.939567353092733 0.6635829962665268 0.9916648424578365 2.0787888325633346 0.9981065997752588 0.01680967132722637 0.08796467452480035 0.05551406988691368 0.016309750429227644 0.06353763040918269 1.1492979893086145e-07 6.939567353092733 1.087123990105498 LPVPAVK(ub)DTVNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LPVPAVKDTVNR 12 1 P50416;P50416-2 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 1 8847300.0 1217000.0 4807300.0 2823000.0 True False 1011989.4222413828 4781402.120725656 3413276.247922759 1.0 4.724755037592855 3.3728378705411153 19.948762779751995 -9.602671562605721 10.21755823446449 0.9999999996365857 4.048796454066985 0.8714822499283419 0.5519178722976215 0.0 0.0 0.5343921859522621 0.17813072732357663 2.4964819903343264e-10 9.602671562605721 3.0487964544303994 LPVPAVK(ub)DTVNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LPVPAVKDTVNR 12 1 P50416;P50416-2 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 1 21417000.0 4258500.0 9864400.0 7294100.0 True False 5512712.197584646 9315437.4684955 5966648.643786194 1.0 1.6898102303575706 1.0823435778853896 22.394330853873882 -10.237092033875701 4.499707332174334 0.9998575081246708 1.386076904125309 0.3500454751734178 0.24799722239910982 174970652.10844254 64.66118426596674 258331.23826858844 0.08489604556462117 5.793059193232785e-11 10.237092033875701 0.38621939600063815 LQAALDDEEAGGRPAMEPGNGSLDLGGDSAGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LQAALDDEEAGGRPAMEPGNGSLDLGGDSAGR 32 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 40231330.0 13574700.0 5112730.0 21543900.0 False True 13143778.57891511 7154269.7515347265 15900906.2868538 1.0 0.5443084504642683 1.2097667494461295 23.647876746067443 -6.722369433420349 1.7506282901986505 0.723470471495603 1.2088820772767332 0.5237524656263335 0.19170287309496353 0.3507318261188006 2.1018913962990253 0.08690325125316031 0.2175673220926112 1.8950931707828857e-07 6.722369433420349 0.4854116057811303 LQAAVDGPMDK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQAAVDGPMDKK 12 1 P51572-2;P51572;A0A2R8Y5M6 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 3592200.0 1053300.0 861100.0 1677800.0 True False 1442733.4743622178 823053.7547230918 1281538.1953756583 1.0 0.5704821918594044 0.8882709233194868 20.4603733752304 -10.266892608477086 5.7137895740104625 1.0000175204010757 0.7293765575894423 0.4915920841105853 0.12973670634727058 2.895749086379067e-05 3.715469029488974e-06 0.12562515254006035 0.04187234192289664 5.4088805619179087e-11 10.266892608477086 -0.2706409628116334 LQAEAPHIVVGTPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQAEAPHIVVGTPGR 15 0 Q14240-2;Q14240;E7EQG2 Q14240-2 EIF4A2 Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 15744000.0 2815700.0 4761700.0 8166600.0 False True 3691409.967277588 4051272.920961228 7321598.571558776 1.0 1.0974865855793956 1.9834151818575843 21.815740541238092 -6.927803905557295 0.7645966591802164 0.9853742999790559 2.155525874219319 0.9960889893950567 0.027666989797559844 0.09379370741592036 0.0833824729144675 0.02488445711263583 0.08115036808333663 1.1808536992488499e-07 6.927803905557295 1.170151574240263 LQAEAPHIVVGTPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQAEAPHIVVGTPGR 15 0 Q14240-2;Q14240;E7EQG2 Q14240-2 EIF4A2 Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 18759000.0 2815700.0 7067100.0 8876200.0 False True 3856740.3814314017 6754852.154225493 6779824.371077263 1.0 1.7514407209640794 1.7579156750398064 21.878950602760984 -11.156366656728672 0.7747509110163348 3.652102841961982e-07 1.756583790709118 0.9999906149833178 0.0010898807101984494 3.7293080800775638 0.4091560321223771 6.5068752761627255 0.0009507792571795778 6.9764316433262896e-12 11.156366656728672 1.7565834254988337 LQAEAQQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQAEAQQLR 9 0 Q16543;K7EQA9;K7EKQ2 Q16543 CDC37 Hsp90 co-chaperone Cdc37;Hsp90 co-chaperone Cdc37, N-terminally processed 0 5243660.0 1402000.0 488060.0 3353600.0 False True 1357494.2774160004 682944.9031992767 2475191.5541565297 1.0 0.5030922889039848 1.8233532143266737 20.372514685614615 -6.804748708926723 1.4364734808355923 0.7274629452448327 1.8437826730722653 0.8456772271215517 0.21388478277188797 0.21404881626730027 0.8714262459468088 0.11711049326121445 0.2716036927361138 1.5676578844946283e-07 6.804748708926723 1.1163197278274326 LQAEGK(ub)TSLHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQAEGKTSLHK 11 1 Q9H4E7 Q9H4E7 DEF6 Differentially expressed in FDCP 6 homolog 1 2449670.0 769740.0 830500.0 849430.0 True False 1009136.5941727641 706592.6372636441 761539.1319079141 1.0 0.7001952375365703 0.7546442536177997 19.94469003653161 -10.597639624934661 6.454706511702273 1.000689249182348 0.727419745577187 0.9709432896167312 0.0222287177326013 0.0002210141941250282 1.377713969044841e-05 0.021575021148303883 0.007174287798825851 2.5255756113464062e-11 10.597639624934661 -0.273269503605161 LQAEGK(ub)TSLHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQAEGKTSLHK 11 1 Q9H4E7 Q9H4E7 DEF6 Differentially expressed in FDCP 6 homolog 1 4474890.0 992690.0 1310700.0 2171500.0 True False 961177.5993210337 1834069.3452102053 1602719.0063963835 1.0 1.908148240768172 1.667453556479602 19.87444350063551 -10.203883377910774 6.062549875531742 0.9999882626255547 1.7878008986238765 0.9345705301300853 0.09826319338456203 1.5601897301224214e-05 2.048605511064855e-06 0.09514434304076225 0.03171430929362857 6.253405943693651e-11 10.203883377910774 0.7878126359983217 LQAEGK(ub)TSLHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQAEGKTSLHK 11 1 Q9H4E7 Q9H4E7 DEF6 Differentially expressed in FDCP 6 homolog 1 3729910.0 992690.0 2215600.0 521620.0 True False 825465.7186234996 2203664.1230378333 630688.3303016187 1.0 2.669601018334886 0.7640393974849969 19.654848776069787 -6.675221452280511 1.9186784054511357 2.0608586834752605 0.7715042161399619 0.3024804557838845 0.7083649053426345 0.44922408194581553 3.192971904942197 0.2966905333311684 0.7873783564938135 2.1124116196103173e-07 6.675221452280511 -1.2893544673352986 LQAENTALQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQAENTALQK 10 0 A0A087WT45;Q4V328-4;Q4V328 A0A087WT45 GRIPAP1 GRIP1-associated protein 1 0 15822600.0 5684800.0 5749300.0 4388500.0 False True 7452827.851681516 4891526.8505958775 3934420.1174645075 1.0 0.6563316566465769 0.5279097002860221 22.82935650543682 -13.999999999999998 0.13665344934013726 2.6374492159916727 0.36238571621560034 0.9996166063896224 0.003902295284441157 11.932050168101727 0.11556329791498357 5.220684542393195 0.14766841811145184 1.0000000000000041e-14 13.999999999999998 -2.2750634997760724 LQAENTALQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQAENTALQK 10 0 A0A087WT45;Q4V328-4;Q4V328 A0A087WT45 GRIPAP1 GRIP1-associated protein 1 0 9067600.0 2218500.0 1348000.0 5501100.0 False True 2148074.9318455015 1886263.4297271348 4060196.8805374824 1.0 0.8781180776159268 1.8901560743270704 21.034612889424213 -6.876806463918072 1.0974066132431235 0.9272174124380602 1.9576404263956868 0.9710190848131033 0.07679497321478944 0.1304988516666559 0.2896731027791942 0.05405019618909918 0.12971538527290258 1.3279861207212006e-07 6.876806463918072 1.0304230139576265 LQAENTALQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQAENTALQK 10 0 A0A087WT45;Q4V328-4;Q4V328 A0A087WT45 GRIPAP1 GRIP1-associated protein 1 0 14037100.0 5684800.0 3891200.0 4461100.0 False True 7786624.185943547 3719273.9175223494 3407480.0592384976 1.0 0.47764908498298936 0.43760684705827946 22.89256656695971 -13.999999999999991 0.36426392802155705 8.01890504495344 0.4330759459216766 0.9997809195171629 0.003792086591683097 22.16454083984209 0.19540431261733968 121.17260987557715 0.011396235589613269 1.0000000000000205e-14 13.999999999999991 -7.585829099031764 LQAENTALQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQAENTALQK 10 0 A0A087WT45;Q4V328-4;Q4V328 A0A087WT45 GRIPAP1 GRIP1-associated protein 1 0 5620100.0 2218500.0 1970800.0 1430800.0 False True 1844781.0462140564 1960182.9092268308 1729973.664728263 1.0 1.062555858999965 0.9377663914525757 20.81501816485849 -6.770412260099108 1.5728017529410963 1.035862181941511 0.9370526241307084 0.7321300586159609 0.02636724610875623 0.26578051218863824 1.2975702648834542 0.013213482223878784 0.03144263563426556 1.6966323358728484e-07 6.770412260099108 -0.09880955781080258 LQAFSAAIESCNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQAFSAAIESCNK 13 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 28796300.0 8478400.0 11745000.0 8572900.0 False True 11115264.504942387 9992691.781651434 7685858.545063569 1.0 0.8990062069335549 0.691468794255509 23.406038944148932 -6.959511185290566 0.44226869650307776 1.007247547642096 0.5751053112865294 0.9997516369919657 0.0020240889443959953 0.07987618828252582 0.02177997558421913 0.0027441617637629485 0.01718856732764998 1.0977130182193969e-07 6.959511185290566 -0.4321422363555665 LQAFSAAIESCNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQAFSAAIESCNK 13 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 53812500.0 9039500.0 31705000.0 13068000.0 False True 13713582.37597082 26046995.037704356 10485104.072092138 1.0 1.8993574635424482 0.7645780500406897 23.709102157351936 -6.69552726026818 1.8470217268410318 1.5609113549742473 0.7682495499003815 0.3962469428408103 0.3799519769391043 0.40492486236202485 2.6824286428299082 0.16431782069736267 0.4248992115633939 2.0159174293961679e-07 6.69552726026818 -0.7926618050738657 LQAFSAAIESCNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQAFSAAIESCNK 13 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 37907500.0 9039500.0 18417000.0 10451000.0 False True 11701810.945184078 17392077.760155883 8549025.236315593 1.0 1.4862723249954448 0.7305728383719936 23.480228479444385 -6.73297939757305 1.712737098419471 1.2916645586306235 0.7308026160773373 0.5728894339702579 0.20437283744671048 0.3306665686296734 1.9017018885119485 0.09451695107049704 0.233717281971071 1.849356348219252e-07 6.73297939757305 -0.5608619425532861 LQAGEYVSLGK(ub)VEAALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQAGEYVSLGKVEAALK 17 1 O60488-2;O60488;O95573 O60488-2;O95573 ACSL4;ACSL3 Long-chain-fatty-acid--CoA ligase 4;Long-chain-fatty-acid--CoA ligase 3 1 20001200.0 3221000.0 2597200.0 14183000.0 True False 4886492.486642178 2133709.3679837775 11379723.833370265 1.0 0.43665458891352676 2.3288123054477468 22.220367842718698 -6.826929000454737 1.341630564987478 0.6982904436713455 2.3765897107857943 0.8995809564146934 0.25137605666738383 0.18463189840878905 0.651035346596526 0.1471590592479003 0.33871852863625196 1.4896045820789653e-07 6.826929000454737 1.6782992671144488 up LQAK(ub)K(ub)EEIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQAKKEEIIK 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 2 15624500.0 3385800.0 7032300.0 5206400.0 True False 4438816.588133844 5983108.251690708 4667691.671315301 1.0 1.3479061666312533 1.0515621852439911 22.081743667071105 -10.076411996918345 10.951219677066941 0.9999999853806416 1.199734175937801 0.37721525253339694 0.1209819237906049 0.0 0.0 0.1171402440082868 0.03904674800276226 8.386640037363488e-11 10.076411996918345 0.19973419055715946 LQAK(ub)K(ub)EEIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQAKKEEIIK 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 2 20471900.0 5563700.0 9230100.0 5678100.0 True False 5387083.388915411 12915727.064335624 4190835.2706513023 1.0 2.397536130758868 0.7779414143234654 22.361072966753568 -6.678433077640634 1.9076614391479747 1.8854826901296495 0.7842076186683757 0.3169072033782402 0.5925133534776605 0.44199523145295605 3.108555113048714 0.24936320391018824 0.658952033570963 2.0968478679691674e-07 6.678433077640634 -1.1012750714612738 LQAK(ub)K(ub)EEIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQAKKEEIIK 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 2 22824500.0 13796000.0 4271500.0 4757000.0 True False 20929540.622699637 3509217.4516181755 3816776.8649328295 1.0 0.16766815454191905 0.18236314564846456 24.319037310796737 -9.996422725077684 4.716012467287641 1.0000151502934462 0.17501565006050848 0.9997620938954298 0.00599920512745123 12118731.38822225 26949287.735983957 2951.8132942107195 0.00219548334829618 1.0082709971643505e-10 9.996422725077684 -0.8249995002329378 LQAK(ub)K(ub)EEIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQAKKEEIIK 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 2 16826700.0 3385800.0 5775500.0 7665400.0 True False 4637621.757804612 5520319.312975516 5854990.393868504 1.0 1.1903340982229567 1.262498474355998 22.144953728593997 -13.999999999999998 0.13447742774646657 0.094240181378637 1.3580396416968494 0.9996258368121856 0.0021417787717409945 11.93248810995492 0.11445885305222714 2.846304316805247 0.08513596212821266 1.0000000000000041e-14 13.999999999999998 1.2637994603182123 LQAK(ub)K(ub)EEIIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQAKKEEIIK 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 2 19685700.0 5563700.0 11061000.0 3061000.0 True False 4626463.0637012245 11001412.197563414 3701040.947535095 1.0 2.3779314880690205 0.799972008114168 22.141478242187844 -6.675942211294573 1.9161009898229846 1.8750001215373182 0.8061333940020675 0.3056465594020029 0.5845280191573499 0.4476598500284074 3.173955693168513 0.24509209900344625 0.6498422432284182 2.1089087498572186e-07 6.675942211294573 -1.0688667275352506 LQAK(ub)K(ub)EEIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQAKKEEIIK 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 2 21133800.0 13796000.0 5552100.0 1785700.0 True False 17859193.959816303 5243120.754311859 1460720.9228292762 1.0 0.2935810410094112 0.08179097702370779 24.090163632889187 -10.344349633370866 0.27537447384901653 1.6593743489628665 7.679654534102123e-20 0.9990014065686655 0.012405372445035813 1.9266069989426624 0.13494933079393914 0.9942731502375914 0.08387134813468951 4.525331166389338e-11 10.344349633370866 -1.6593743489628665 LQAK(ub)KEEIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQAKKEEIIK 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 5406800.0 2038700.0 999700.0 2368400.0 True False 2672755.4427988813 850548.6568000788 2123340.687297015 1.0 0.31822913656080454 0.7944388226831091 21.349896406305703 -9.816178653451027 6.021641490872313 1.0000000329995815 0.556333979621812 0.5364625732907371 0.19441179026386066 8.615356966533348e-08 1.676934195769237e-08 0.1882384205234677 0.06274613549955128 1.526937800603447e-10 9.816178653451027 -0.44366605337776954 LQAK(ub)KEEIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQAKKEEIIK 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 24806100.0 11456000.0 5889300.0 7460800.0 True False 17379589.54578479 4838308.401689075 5986169.609815193 1.0 0.2783902570853607 0.344436765554516 24.05089067460014 -10.128496415702127 5.209381888493633 1.0000198592804586 0.3114135113570605 0.9931473632488543 0.026963374175934526 15749715.694117432 30621856.22416764 2531.5156220870663 0.009230282179150317 7.438812022460098e-11 10.128496415702127 -0.688606347923398 LQAK(ub)KEEIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQAKKEEIIK 10 2 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 25943200.0 11456000.0 7048800.0 7438400.0 True False 14830017.831520407 6656528.083606818 6084687.524429235 1.0 0.4488550289844376 0.41029536131079747 23.82201699669259 -13.999999999999998 0.37768469325907855 9.058183292041178 0.4067694833781348 0.9998037606246538 0.0037733547231649316 23.745303604758515 0.20019610371011437 155.42714300918198 0.010524592144771682 1.0000000000000041e-14 13.999999999999998 -8.651413808663044 LQALEK(ub)DKPSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQALEKDKPSLR 12 2 P13489 P13489 RNH1 Ribonuclease inhibitor 1 8813300.0 2624500.0 3876800.0 2312000.0 True False 2182388.0350636914 3855914.9089154545 2795428.510519812 1.0 1.766832867007962 1.2809035174343912 21.057476209249046 -10.195467867184146 3.943499601135549 0.9996678806703196 1.5238681921118549 0.6077909009437301 0.19837982705197246 17523126.19815636 6472100.833535809 51786.81408618132 0.06791069215577276 6.37576252627651e-11 10.195467867184146 0.5242003114415352 LQALK(ub)DTANR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQALKDTANR 10 1 P29401;P29401-2;E9PFF2;F8W888;F8WAX4 P29401 TKT Transketolase 1 12166100.0 2580400.0 4019400.0 5566300.0 True False 2498486.6144395503 5624367.3808940975 4108319.0445794133 1.0 2.251109671106135 1.6443230157152446 21.25262305822711 -10.059263703708252 5.500804012303884 0.9999936631658347 1.947716343411207 0.7648467475923171 0.24771961474143592 1.9251332450666513e-05 3.292604302791633e-06 0.2398550887946674 0.07995116186827772 8.724414608708114e-11 10.059263703708252 0.9477226802453723 LQALK(ub)DTANR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQALKDTANR 10 1 P29401;P29401-2;E9PFF2;F8W888;F8WAX4 P29401 TKT Transketolase 1 30738400.0 5454000.0 3857400.0 21427000.0 True False 8274116.740809208 3169016.831996241 17191944.0582123 1.0 0.3830036402998964 2.077798101810554 22.980173882251147 -6.808199702224256 1.4221029263740197 0.6630179180388792 2.1062368857398286 0.8550652102437771 0.26663292274259237 0.2092700887408814 0.8344708932148721 0.14744051785277706 0.3413444536257304 1.5552503142806837e-07 6.808199702224256 1.4432189677009495 up LQALK(ub)DTANR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQALKDTANR 10 1 P29401;P29401-2;E9PFF2;F8W888;F8WAX4 P29401 TKT Transketolase 1 12327800.0 2580400.0 6551400.0 3196000.0 True False 2145716.931102439 6516106.30784892 3864268.8233656185 1.0 3.036796798961286 1.8009219983086082 21.033028333661385 -10.069735458037952 4.768261711188607 0.9999679335573658 2.4188593985598184 0.6373383956998067 0.5045437748036843 175076841.16735628 12.110968318717463 99998.23703846801 0.17271875416018365 8.51656650172675e-11 10.069735458037952 1.4188914650024524 LQALK(ub)DTANR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQALKDTANR 10 1 P29401;P29401-2;E9PFF2;F8W888;F8WAX4 P29401 TKT Transketolase 1 18425100.0 5454000.0 3620500.0 9350600.0 True False 7060310.514412738 3419015.9923247155 7648886.745258112 1.0 0.48425858683484574 1.0833640715438606 22.751300204343597 -6.678932742852159 1.9059626068178557 0.6733674204844938 1.0810498629580942 0.3191394413579757 0.21863534926033698 0.4408875164362784 3.09570264838873 0.09208296691032396 0.24317000394532579 2.0944367863303211e-07 6.678932742852159 0.4076824424736004 LQANLTFDPAALLPGASPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQANLTFDPAALLPGASPK 19 0 B7ZKW8;Q6JBY9 B7ZKW8 RCSD1 CapZ-interacting protein 0 12412800.0 8782600.0 3630200.0 0.0 False True 8503801.170352187 5079757.791242909 0.0 1.0 0.5973514301995997 0.0 23.019676434549222 -7.658332184492593 0.6594209276506721 0.9986134174995525 2.8018408371654662e-15 0.9873024162459754 0.04629261157787255 0.12089732052097782 0.14920374409521217 0.04259531752660584 0.07763797364598603 2.196179409758968e-08 7.658332184492593 -0.9986134174995497 down LQANLTFDPAALLPGASPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQANLTFDPAALLPGASPK 19 0 B7ZKW8;Q6JBY9 B7ZKW8 RCSD1 CapZ-interacting protein 0 86680000.0 31590000.0 32419000.0 22671000.0 False True 47924339.53835038 26633576.15919687 18190066.91294769 1.0 0.5557421639140994 0.37955800931573597 25.51425521397012 -13.999999999999998 0.1276744639015367 3.111037055463039 0.12537909595081392 0.999656267704225 0.004839987700943666 11.940927967980272 0.11088018902796189 6.339722490003026 0.22587229806359085 1.0000000000000041e-14 13.999999999999998 -2.985657959512225 LQANLTFDPAALLPGASPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQANLTFDPAALLPGASPK 19 0 B7ZKW8;Q6JBY9 B7ZKW8 RCSD1 CapZ-interacting protein 0 14284100.0 8782600.0 2703500.0 2798000.0 False True 7303121.035149694 2688935.708897268 3383048.8635097016 1.0 0.3681899418009785 0.4632333008349708 22.8000817099835 -10.790056480135988 7.200934409630313 1.0179819891854232 0.4157116213179747 0.9805411946477494 0.038801288845570485 0.010603361243118224 0.00030914101294014513 0.03556319171076997 0.012523062125856507 1.6215991941524382e-11 10.790056480135988 -0.6022703678674485 LQAQEEQHQEVQK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQAQEEQHQEVQKAK 15 1 Q96R06;K7ELG0 Q96R06 SPAG5 Sperm-associated antigen 5 1 2934440.0 440610.0 804360.0 1689470.0 True False 577643.9768733095 684352.6233707236 1514659.8509405856 1.0 1.184730821699224 2.6221338948935067 19.139821055307824 -6.930616340623714 0.741718969924038 0.9786340134097127 2.9219076718699974 0.9966579637373095 0.04191669389963996 0.092318971725365 0.0761224039859785 0.03832912258912135 0.1296220807411441 1.1732313502657465e-07 6.930616340623714 1.9432736584602848 up LQAQEEQHQEVQK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQAQEEQHQEVQKAK 15 1 Q96R06;K7ELG0 Q96R06 SPAG5 Sperm-associated antigen 5 1 2746580.0 644030.0 780150.0 1322400.0 True False 623585.6201741991 1091667.9634285052 976023.7688503696 1.0 1.7506304316695869 1.5651800446869135 19.25022813444402 -10.071769984267458 4.569845411925219 0.9999650180209042 1.6579052380164414 0.9437592274760659 0.07570980355925644 52553265.064164385 2.551590616031491 20845.456612900845 0.025917479504795192 8.476762507194526e-11 10.071769984267458 0.6579402199955372 LQAQEEQHQEVQK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQAQEEQHQEVQKAK 15 1 Q96R06;K7ELG0 Q96R06 SPAG5 Sperm-associated antigen 5 1 16900420.0 526520.0 5218200.0 11155700.0 True False 798769.333768035 4286971.440017308 8950771.005282996 1.0 5.3669704867040595 11.205701855202076 19.607419420551153 -6.967098223169467 0.32000419060157353 0.20042630305996498 16.560571655174204 0.9999500913265775 0.029536250240245036 0.07725598770455218 0.01238651963658574 0.08850215046073287 0.5135859377041347 1.0787027274573018e-07 6.967098223169467 16.360145352114237 LQAQEEQHQEVQK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQAQEEQHQEVQKAK 15 1 Q96R06;K7ELG0 Q96R06 SPAG5 Sperm-associated antigen 5 1 2540470.0 440610.0 1277530.0 822330.0 True False 603515.4240375358 1221084.5003732347 628112.5904179679 1.0 2.0232863183581022 1.040756483431486 19.203031116830715 -6.636670594810515 2.0564892132673096 1.670849459936318 1.044810665197242 0.1419841375379005 0.4381989406557127 0.541798895453484 4.375053114191773 0.17377128122482532 0.485244831231976 2.308497482053003e-07 6.636670594810515 -0.626038794739076 LQAQEEQHQEVQK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQAQEEQHQEVQKAK 15 1 Q96R06;K7ELG0 Q96R06 SPAG5 Sperm-associated antigen 5 1 2780880.0 644030.0 1373130.0 763720.0 True False 535539.4803665724 1365732.6761450353 923410.320957695 1.0 2.5501998007881745 1.7242618981622573 19.030633409878295 -9.938687638625858 5.187747901200743 0.9999964516401755 2.1372308494868753 0.7165365163029365 0.3371877368170165 1.3838606291426894e-05 2.8311604102634106e-06 0.3264816384566149 0.10882687409728715 1.1516283867837082e-10 9.938687638625858 1.1372343978466999 LQAQEEQHQEVQK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQAQEEQHQEVQKAK 15 1 Q96R06;K7ELG0 Q96R06 SPAG5 Sperm-associated antigen 5 1 8921820.0 526520.0 4717200.0 3678100.0 True False 681590.519260835 4454683.673247945 3008723.540493004 1.0 6.5357183636869225 4.414268472742075 19.378545742643603 -9.887204917886374 8.166488867649182 0.999999996342777 5.474993418214499 0.8557576446850149 0.8660782912829835 5.5608610893735604e-08 6.1205086601689155e-09 0.8385766996626889 0.2795255665542308 1.2965673531628743e-10 9.887204917886374 4.474993421871722 LQAQQDAVNIVCHSK(ub)TR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQAQQDAVNIVCHSKTR 17 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 1299130000.0 132290000.0 368950000.0 797890000.0 True False 173433471.09818223 313904098.1558359 715331996.7013235 1.0 1.8099395472407516 4.124532549408341 27.369807111680732 -6.952537492902484 0.5302548567549109 0.9635620347073547 5.076029334957184 0.9993856668767176 0.03281555798417802 0.08248253460235101 0.031867149938237575 0.03659689296530528 0.19141082709508705 1.1154818469786046e-07 6.952537492902484 4.112467300249829 LQAQQDAVNIVCHSK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQAQQDAVNIVCHSKTR 17 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 682300000.0 183780000.0 176260000.0 322260000.0 True False 177946004.49608588 246641537.18375733 237850438.4072294 1.0 1.3860470645699858 1.336643882962043 27.406864298811467 -10.079250667592731 4.42674049047219 0.9999700239863422 1.3613454737927828 0.9861745369059817 0.020168764528176255 3050943.99078123 3473349.2911197273 720.0738470491259 0.006904304896856985 8.332001364668985e-11 10.079250667592731 0.36137544980644065 LQAQQDAVNIVCHSK(ub)TR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQAQQDAVNIVCHSKTR 17 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 2147830000.0 374250000.0 948580000.0 825000000.0 True False 567764611.3399061 779298487.7106317 661938388.3896543 1.0 1.3725731969653983 1.1658676415698068 29.08071768805639 -10.166678746067847 4.307619260722319 0.9999337481253263 1.2692204191353063 0.6934189645168936 0.08438718968852638 59128575.034853116 5.397935027153808 40618.394547811375 0.028887979587659714 6.812731199666915e-11 10.166678746067847 0.26928667100997994 LQAQQDAVNIVCHSK(ub)TR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQAQQDAVNIVCHSKTR 17 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 1568190000.0 132290000.0 325900000.0 1110000000.0 True False 181201188.00282693 311500660.39281815 847840861.1675899 1.0 1.7190872964252222 4.679002773173665 27.433017173203623 -6.944216980583571 0.6190892091604602 0.9675834468272585 5.587073076609846 0.99866571301898 0.05815632088861916 0.08589438384044563 0.04623676794226745 0.05861660553506922 0.25041294045240275 1.1370590506983734e-07 6.944216980583571 4.619489629782588 LQAQQDAVNIVCHSK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQAQQDAVNIVCHSKTR 17 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 935410000.0 183780000.0 103770000.0 647860000.0 True False 152821212.8344465 103210970.41326773 783324530.6338077 1.0 0.6753707060621075 5.125757845426831 27.187269574245743 -6.889352457655143 1.0261862283364194 0.7571507019384799 5.503739054955476 0.98048128267143 0.28301724333238254 0.11967089472495737 0.22491951501613283 0.21031443742980777 0.5231195920332626 1.2901717919738193e-07 6.889352457655143 4.746588353016996 up LQAQQDAVNIVCHSK(ub)TR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQAQQDAVNIVCHSKTR 17 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 1831870000.0 374250000.0 1037800000.0 419820000.0 True False 484474002.5704013 980045517.7004808 343417067.71696615 1.0 2.0229063117954724 0.708845192714056 28.851844010148838 -6.698960979555836 1.8345090961882637 1.6358318298511885 0.7128229097444224 0.4126510369943489 0.43186470163696483 0.3977022620711453 2.601368979447461 0.18785549723611564 0.48374716800657924 2.0000415610804578e-07 6.698960979555836 -0.923008920106766 LQASNVTNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQASNVTNK 9 0 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 0 1768090.0 1190500.0 577590.0 0.0 False True 1152708.2291467548 808224.6990920586 0.0 1.0 0.70115288383975 0.0 20.136595956874327 -7.426383539286208 0.748117098788869 0.9910106072900416 8.46755474173361e-18 0.9873210099444409 0.04719290391351625 0.1150336638381457 0.13976413659270484 0.04106118669264761 0.07379442025883831 3.7464199782871854e-08 7.426383539286208 -0.9910106072900416 down LQASNVTNK(ub)NDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQASNVTNKNDPK 13 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 8964500.0 2136400.0 4028600.0 2799500.0 True False 2800841.0889270306 3427548.583359806 2509834.5947002163 1.0 1.2237568910676255 0.8961003195157011 21.417428700997732 -6.722827769814082 1.7488550967808114 1.1357134192588085 0.8965169272722503 0.5259951737796045 0.09412616947423459 0.34983199782240126 2.092466082947673 0.04270780561058463 0.1068691786966179 1.893094222995097e-07 6.722827769814082 -0.23919649198655824 LQASNVTNK(ub)NDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQASNVTNKNDPK 13 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 13174200.0 4180800.0 4434800.0 4558600.0 True False 4048082.7924542194 6205638.767176479 3364565.9049314098 1.0 1.5329821758448285 0.8311504673775667 21.94880736603665 -6.703686954491801 1.8179151955386956 1.3297674282655787 0.8331034907582937 0.43495672613398806 0.2248316436059257 0.3879268413498737 2.4949608138460184 0.09857573185494 0.2523451556673463 1.9783951810622286e-07 6.703686954491801 -0.496663937507285 LQASNVTNK(ub)NDPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQASNVTNKNDPK 13 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 11970300.0 4180800.0 5832500.0 1957000.0 True False 3476520.440843696 5801079.164839388 2366199.651854354 1.0 1.6686452053282215 0.6806229654384299 21.729212641470927 -6.7244480572445635 1.7432844647412247 1.4048665625979397 0.6817705771637008 0.5333268990655337 0.2812285157480854 0.3468007947100181 2.0620160854061496 0.12797408351460096 0.31959744731913803 1.886044531858016e-07 6.7244480572445635 -0.7230959854342389 LQASQVK(ub)LK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQASQVKLK 9 1 Q9BXW9;Q9BXW9-1;Q9BXW9-3 Q9BXW9 FANCD2 Fanconi anemia group D2 protein 1 1874140.0 506080.0 666200.0 701860.0 True False 663475.7808856914 566805.5568272616 629238.2599165181 1.0 0.8542972828196047 0.9483967283274927 19.33968427773563 -10.615848115475575 5.222363108358582 1.0009725896468795 0.9013470055735484 0.5944023802325423 0.038415937762193604 0.0004392513056056137 3.2310855109541167e-05 0.037557810353628374 0.012398690598492905 2.421875894136883e-11 10.615848115475575 -0.09962558407333111 LQASQVK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQASQVKLK 9 1 Q9BXW9;Q9BXW9-1;Q9BXW9-3 Q9BXW9 FANCD2 Fanconi anemia group D2 protein 1 3216150.0 358050.0 1696900.0 1161200.0 True False 297734.43930445943 1687758.4628917228 1404001.5512178212 1.0 5.668670600668546 4.715616891676099 18.183666583953837 -9.891591598463096 6.4384712014793894 0.9999996950181123 5.192143746172638 0.9626829782091444 0.38908254741754383 1.7093712599798982e-06 2.964447509451426e-07 0.3767276015129655 0.12557585220384174 1.2835370269486584e-10 9.891591598463096 4.192144051154526 LQATVQELQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQATVQELQK 10 0 P31146;H3BRY3 P31146 CORO1A Coronin-1A;Coronin 0 15239200.0 3080800.0 5973300.0 6185100.0 False True 4038958.634509639 5082106.923741041 5545125.183668615 1.0 1.2582715951380492 1.3729096248448796 21.945551939902582 -13.071405029141843 0.11903064507562826 4.3060995187611014e-20 1.5673380311079126 0.9997226003342362 0.0025975334065635003 8.660933734739285 0.09725249411090232 2.1960573186092174 0.1622679490901558 8.483888865628669e-14 13.071405029141843 1.5673380311079126 LQATVQELQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQATVQELQK 10 0 P31146;H3BRY3 P31146 CORO1A Coronin-1A;Coronin 0 13728200.0 3080800.0 5276400.0 5371000.0 False True 4219855.015489526 5043271.201278512 4102480.419217229 1.0 1.1951290228613376 0.9721851590063028 22.008762001425474 -6.675492005658425 1.9181003275524307 1.123959729595076 0.9730656158416301 0.30348813438776157 0.08278364869370028 0.44864270258198624 3.187272641892117 0.03468337893473549 0.0920001953076318 2.1110960557718642e-07 6.675492005658425 -0.15089411375344597 LQATVQELQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQATVQELQK 10 0 P31146;H3BRY3 P31146 CORO1A Coronin-1A;Coronin 0 5867000.0 3155600.0 1460500.0 1250900.0 False True 2624021.216782997 1452631.9966134466 1512457.4064918798 1.0 0.5535900347613605 0.5763891682042592 21.32334795438073 -10.275825347948766 5.5752124023433804 1.000039909118645 0.5649896014828041 0.9979440855303696 0.009307707252157295 4.617618864691534e-06 5.997858245533589e-07 0.009012973268802791 0.003004049598242983 5.2987649152212674e-11 10.275825347948766 -0.43505030763584085 LQAVEVVITHLAPGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQAVEVVITHLAPGTK 16 0 Q9Y2V2 Q9Y2V2 CARHSP1 Calcium-regulated heat stable protein 1 0 55386000.0 14351000.0 22282000.0 18753000.0 False True 18814299.975281686 18957612.454555713 16812619.45147816 1.0 1.007617210284853 0.8936085569788224 24.165326276180313 -6.890916193201694 1.0169138783227856 1.005991930988868 0.8836236810369251 0.9814793823242816 0.0070823900897319225 0.11840427025352489 0.2175146761525164 0.00530003196415576 0.013257827961489813 1.2855347085790722e-07 6.890916193201694 -0.12236824995194295 LQAVEVVITHLAPGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQAVEVVITHLAPGTK 16 0 Q9Y2V2 Q9Y2V2 CARHSP1 Calcium-regulated heat stable protein 1 0 58761000.0 27253000.0 15368000.0 16140000.0 False True 26387868.432538006 21504522.5430613 11912449.81037881 1.0 0.8149397363428107 0.45143660772879873 24.653371481112618 -6.9603961301689194 0.42981419037563223 1.0144673867737073 0.23797347186649048 0.9997846103823688 0.003344183147521278 0.0795599187874565 0.02061066678422398 0.004739149566972148 0.030183315394994765 1.095478528678309e-07 6.9603961301689194 -0.7764939149072168 down LQAVEVVITHLAPGTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQAVEVVITHLAPGTK 16 0 Q9Y2V2 Q9Y2V2 CARHSP1 Calcium-regulated heat stable protein 1 0 106986000.0 20764000.0 50445000.0 35777000.0 False True 31500506.051734947 41442695.62141601 28705660.268383812 1.0 1.3156199952265046 0.9112761623968513 24.908871669727713 -6.698456215319712 1.8366623869028005 1.196284948246501 0.9125240066642103 0.4101580554953309 0.1332651712796012 0.3987233676517179 2.6139012250247062 0.05791328002338362 0.1492062530459521 2.0023674860024488e-07 6.698456215319712 -0.2837609415822907 LQAVEVVITHLAPGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQAVEVVITHLAPGTK 16 0 Q9Y2V2 Q9Y2V2 CARHSP1 Calcium-regulated heat stable protein 1 0 46782000.0 14351000.0 16109000.0 16322000.0 False True 19656952.52119261 15397251.114660658 12467079.762141814 1.0 0.7832979755158145 0.6342325825277734 24.228536337703204 -7.659955746452062 0.08600386594524057 1.5160644244933843 5.765026291189171e-07 0.9999975785356011 0.0002336129503691574 0.1383797861745141 0.009473019672896132 0.07121435381869615 0.0908517267778185 2.1879845628787178e-08 7.659955746452062 -1.516063847990755 LQAVEVVITHLAPGTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQAVEVVITHLAPGTK 16 0 Q9Y2V2 Q9Y2V2 CARHSP1 Calcium-regulated heat stable protein 1 0 45749000.0 27253000.0 9585700.0 8910300.0 False True 22662077.01260842 9534059.931487523 10773402.53342763 1.0 0.420705477533374 0.47539343050655375 24.433776756546894 -10.72191615659503 10.596309352020539 1.0006240763661614 0.4480494548159103 0.992690993056106 0.022326263310268775 0.00032945843064204197 8.646111079016453e-06 0.021636734992635617 0.007205770498642725 1.897072128107181e-11 10.72191615659503 -0.552574621550251 LQAVEVVITHLAPGTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQAVEVVITHLAPGTK 16 0 Q9Y2V2 Q9Y2V2 CARHSP1 Calcium-regulated heat stable protein 1 0 89441000.0 20764000.0 44553000.0 24124000.0 False True 26879407.31963075 42073586.38476539 19733679.533142976 1.0 1.5652721015927282 0.734156051079703 24.679997991820162 -6.723602639435632 1.7467353246589001 1.3425826596390724 0.7352153351308964 0.5292990562610537 0.2377694097721377 0.34835940152599093 2.079141396051945 0.10801253594884444 0.2699704603550416 1.8897195695785848e-07 6.723602639435632 -0.607367324508176 LQAYHTQTTPLIEYYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQAYHTQTTPLIEYYR 16 0 P54819;F8W1A4;P54819-2;P54819-5;A0A5K1VW67;P54819-6;F8VY04 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 0 94629000.0 35638000.0 26699000.0 32292000.0 False True 46721763.11888296 22715613.27188688 28950733.606736705 1.0 0.486189128053393 0.6196412907850226 25.477591381812903 -10.260536021030704 8.331013805985219 1.0000003089621512 0.5529152094192494 0.9373617065622046 0.05448161729389305 3.1264600284063736e-07 2.783431254999925e-08 0.05275163527033446 0.017583866371141156 5.488630302024818e-11 10.260536021030704 -0.44708509954290176 LQAYHTQTTPLIEYYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQAYHTQTTPLIEYYR 16 0 P54819;F8W1A4;P54819-2;P54819-5;A0A5K1VW67;P54819-6;F8VY04 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 0 56864800.0 14035000.0 6968800.0 35861000.0 False True 13589466.607370589 9751478.181811903 26467928.29306042 1.0 0.7175762274968867 1.947679703536331 23.695985495003878 -6.846322293087108 1.2528290933373532 0.8496415971519345 1.993439334100596 0.934756872616794 0.1343798846525512 0.16155649777791692 0.48984071817867764 0.08400789248357797 0.19398292392615746 1.4245500323204737e-07 6.846322293087108 1.1437977369486614 LQAYHTQTTPLIEYYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQAYHTQTTPLIEYYR 16 0 P54819;F8W1A4;P54819-2;P54819-5;A0A5K1VW67;P54819-6;F8VY04 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 0 84516600.0 10290000.0 65548000.0 8678600.0 False True 15610682.29976654 53850447.2711385 6963270.906034485 1.0 3.449589597499133 0.44605807563828404 23.896030259117214 -6.689859436154428 1.8667253959729793 2.5359546533106787 0.456416016634683 0.36977940382768404 1.0360374920312856 0.417012926032349 2.817246028800001 0.44399206630601107 1.1564720269673263 2.0423988809661692e-07 6.689859436154428 -2.079538636675996 LQAYHTQTTPLIEYYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQAYHTQTTPLIEYYR 16 0 P54819;F8W1A4;P54819-2;P54819-5;A0A5K1VW67;P54819-6;F8VY04 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 0 87955000.0 35638000.0 19867000.0 32450000.0 False True 48814331.68073743 18989210.248616524 24785978.3287282 1.0 0.3890089159227358 0.5077602719389267 25.540801443335795 -10.504074248319359 7.054776983558055 1.0001749809655267 0.4483845939317104 0.9664087246807929 0.048480038083875514 0.00013346677216585402 9.382232151680845e-06 0.04695510437058201 0.015646865010195944 3.1327500939463286e-11 10.504074248319359 -0.5517903870338163 LQAYHTQTTPLIEYYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQAYHTQTTPLIEYYR 16 0 P54819;F8W1A4;P54819-2;P54819-5;A0A5K1VW67;P54819-6;F8VY04 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 0 39302000.0 14035000.0 14956000.0 10311000.0 False True 11670724.355922613 14875429.059466425 12466982.427322548 1.0 1.2745934704487731 1.068226962364667 23.476390770438154 -10.338373282421609 3.906906545340695 0.999554412121732 1.1714102164217357 0.4791355676804073 0.08424877418572739 7230127.350558125 20012869.59517304 15403.344258639443 0.028840594941421223 4.5880349503951783e-11 10.338373282421609 0.1718558043000037 LQAYHTQTTPLIEYYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQAYHTQTTPLIEYYR 16 0 P54819;F8W1A4;P54819-2;P54819-5;A0A5K1VW67;P54819-6;F8VY04 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 0 44851000.0 10290000.0 21947000.0 12614000.0 False True 13320607.846224248 20725630.157036513 10318381.430569798 1.0 1.5559072375898546 0.7746179115613379 23.667156581209664 -6.71560184913431 1.7749301674390845 1.3397773019832937 0.7761069373674281 0.4918134388527352 0.23406182229378858 0.3639170426549377 2.2380588805020967 0.10480259168841978 0.26448543444937433 1.9248555821359734e-07 6.71560184913431 -0.5636703646158656 LQDAEIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQDAEIAR 8 0 R4GN98;P06703 R4GN98 S100A6 Protein S100;Protein S100-A6 0 16820300.0 4095000.0 1852300.0 10873000.0 False True 3965006.4664896755 2591933.049616893 8025035.116991883 1.0 0.6537020989808371 2.023965202784816 21.918891788132363 -6.839726407455166 1.2836744816391794 0.8157722407126177 2.0687883346141906 0.9239830009026377 0.1603993016456285 0.1691170913541715 0.541448224142305 0.09798457142253962 0.22571995147482682 1.446350641485495e-07 6.839726407455166 1.2530160939015729 up LQDDSVETVTSIEQAK(ub)VEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQDDSVETVTSIEQAKVEEK 20 1 P49356 P49356 FNTB Protein farnesyltransferase subunit beta 1 8217200.0 2856800.0 2999400.0 2361000.0 True False 3745292.4652905525 2551901.211569625 2116706.3683112017 1.0 0.6813623329070654 0.5651645066247161 21.836646950691662 -13.999999999999998 0.14028995555884555 2.5224716771669065 0.42186470811721744 0.9996017795756152 0.00366824251316354 11.9342782347045 0.11737178735626422 4.973174212544734 0.12813302284567543 1.0000000000000041e-14 13.999999999999998 -2.100606969049689 LQDILTNSK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQDILTNSKSR 11 1 A0A087WT45;Q4V328-4;Q4V328;A0A087WXA6;Q4V328-3;Q4V328-2 A0A087WT45 GRIPAP1 GRIP1-associated protein 1 1 6276700.0 1813200.0 1556100.0 2907400.0 True False 1755640.9584955 2177458.8449542955 2145864.7198696057 1.0 1.240264323076783 1.2222685449925415 20.743566402602614 -10.044247918188482 4.400729727580377 0.9999859177075388 1.231266434050487 0.9954792571057081 0.007346745735880806 1104470.5360700113 1260424.6324328128 121.14370073850684 0.0025149863390511035 9.031337701671035e-11 10.044247918188482 0.23128051634294833 LQDILTNSK(ub)SR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQDILTNSKSR 11 1 A0A087WT45;Q4V328-4;Q4V328;A0A087WXA6;Q4V328-3;Q4V328-2 A0A087WT45 GRIPAP1 GRIP1-associated protein 1 1 13894900.0 1654000.0 1807900.0 10433000.0 True False 2509238.9235970695 1485266.119812829 8370912.977053658 1.0 0.5919189702683455 3.336036635783452 21.258818416507157 -6.86906807764391 1.139089205310556 0.770479541449018 3.4938734257890713 0.9637403123558212 0.2302056856870543 0.13774757538622412 0.3346395020393724 0.1569365720007433 0.3709443370251411 1.3518606362543748e-07 6.86906807764391 2.7233938843400534 up LQDILTNSK(ub)SR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQDILTNSKSR 11 1 A0A087WT45;Q4V328-4;Q4V328;A0A087WXA6;Q4V328-3;Q4V328-2 A0A087WT45 GRIPAP1 GRIP1-associated protein 1 1 2500180.0 842290.0 916520.0 741370.0 True False 1153707.3750313793 876025.1158736604 566273.6749944291 1.0 0.7593130934521709 0.4908295528396247 20.137845916248892 -6.969712186896218 0.26496821618076727 1.0709484917878136 0.1711764998659485 0.9999800500930512 0.000928892006247914 0.0763962103386814 0.009363695117108509 0.005429882788211188 0.02514777279672974 1.0722296516087068e-07 6.969712186896218 -0.8997719919218651 down LQDILTNSK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQDILTNSKSR 11 1 A0A087WT45;Q4V328-4;Q4V328;A0A087WXA6;Q4V328-3;Q4V328-2 A0A087WT45 GRIPAP1 GRIP1-associated protein 1 1 5923500.0 1813200.0 2804100.0 1306200.0 True False 1507756.1383796846 2788993.7567297295 1579320.3808135714 1.0 1.849764484943123 1.0474640696941837 20.52397167803689 -10.370444790354034 4.204415196752513 0.9989885099857909 1.4486142773245787 0.2942238446111346 0.3275377729836623 0.003112188209801334 0.0004660086111706782 0.31782106485764217 0.10571236166555326 4.261428535105004e-11 10.370444790354034 0.4496257673387878 LQDILTNSK(ub)SR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQDILTNSKSR 11 1 A0A087WT45;Q4V328-4;Q4V328;A0A087WXA6;Q4V328-3;Q4V328-2 A0A087WT45 GRIPAP1 GRIP1-associated protein 1 1 8208700.0 1654000.0 2934500.0 3620200.0 True False 2141135.6052142754 2771192.4953671843 2961360.746388832 1.0 1.2942629549564917 1.3830794925725745 21.029944738599607 -12.87281927441342 0.18263586192235287 1.4498745932984376e-08 1.4554300598607042 0.9994685848447609 0.003774069808271894 7.81030951904581 0.12694825686217212 2.879707786035068 0.06466268676934224 1.3402342911911058e-13 12.87281927441342 1.4554300453619582 LQDLATQLQEK(ub)HHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQDLATQLQEKHHR 14 1 O75150-3;O75150;H3BP71;O75150-4;H3BS50 O75150-3 RNF40 E3 ubiquitin-protein ligase BRE1B 1 3735480.0 801080.0 1122900.0 1811500.0 True False 1050223.6376697551 955367.6970299185 1624063.3571350009 1.0 0.9096802459614185 1.5463976422569254 20.002265141599022 -6.870960659919282 1.1290607478294734 0.9486138702175699 1.5843644893716275 0.9656295960168091 0.05214909350109126 0.13593400366854333 0.3232923247221753 0.03582552637704614 0.08495901245678149 1.3459822728352123e-07 6.870960659919282 0.6357506191540576 LQDLATQLQEK(ub)HHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQDLATQLQEKHHR 14 1 O75150-3;O75150;H3BP71;O75150-4;H3BS50 O75150-3 RNF40 E3 ubiquitin-protein ligase BRE1B 1 4103040.0 801080.0 914660.0 2387300.0 True False 1097260.924373004 874247.296823857 1823468.9079868335 1.0 0.7967542426824493 1.6618370958838244 20.065475203121913 -6.844777357342288 1.2599587331841589 0.8918464938688636 1.6931012883888517 0.9323674366382207 0.0960514163491197 0.1632941024009711 0.5014677109370091 0.05972360204950287 0.1378253224320831 1.4296266740340208e-07 6.844777357342288 0.801254794519988 LQDLATQLQEK(ub)HHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQDLATQLQEKHHR 14 1 O75150-3;O75150;H3BP71;O75150-4;H3BS50 O75150-3 RNF40 E3 ubiquitin-protein ligase BRE1B 1 5683400.0 1256500.0 1994600.0 2432300.0 True False 1044835.4223880838 1983854.6939028997 2940882.6843154537 1.0 1.8987245755590736 2.8146850894409283 19.994844282918923 -6.970888268940614 0.23600853429249657 0.6543862556970755 4.0853864145342635 0.9999885058143183 0.002511713687777232 0.07601549911947475 0.007991548631595955 0.02252758555670232 0.0899448025083255 1.069329950644301e-07 6.970888268940614 3.431000158837188 LQDLATQLQEK(ub)HHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQDLATQLQEKHHR 14 1 O75150-3;O75150;H3BP71;O75150-4;H3BS50 O75150-3 RNF40 E3 ubiquitin-protein ligase BRE1B 1 15264000.0 3187300.0 3475900.0 8600800.0 True False 4126022.681075853 3282463.1094383327 7035542.651660423 1.0 0.7955513973525798 1.705163348696357 21.976320321180108 -6.8476853311432615 1.246274883244581 0.8910811595442396 1.7399211139141852 0.9368596069610788 0.09791044315431721 0.16002223748190625 0.47946538889181933 0.06151140811680352 0.14214096091842657 1.4200860749724298e-07 6.8476853311432615 0.8488399543699456 LQDLLETK(ub)ALALAQADR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQDLLETKALALAQADR 17 1 A0A087X211;Q8TCG1;Q8TCG1-2 A0A087X211 KIAA1524 Protein CIP2A 1 9609300.0 1620500.0 1890200.0 6098600.0 True False 1569058.1145168522 2644966.71726278 4501193.705921706 1.0 1.6857034757295932 2.8687233852442255 20.58146735692183 -6.962828618104481 0.39354923946008985 0.9301555618056372 3.6670207866393083 0.9998611437529326 0.009095337078009419 0.07870579907898775 0.0175082891987478 0.015247933159546829 0.09936687395247756 1.0893598932475479e-07 6.962828618104481 2.736865224833671 LQDLLETK(ub)ALALAQADR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQDLLETKALALAQADR 17 1 A0A087X211;Q8TCG1;Q8TCG1-2 A0A087X211 KIAA1524 Protein CIP2A 1 12208800.0 1620500.0 3330000.0 7258300.0 True False 1347517.5503222356 3312060.629046753 8775976.971412612 1.0 2.457897953354842 6.51269957063935 20.361872632356107 -6.953139265103394 0.5232476840212369 0.9327872557503489 8.219768564379358 0.9994251633297354 0.05591871940842454 0.08224915747048646 0.030931128613795357 0.063026213995782 0.33504119732944704 1.1139372703258712e-07 6.953139265103394 7.2869813086290085 LQDLSSCITQGK(ub)DAAVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQDLSSCITQGKDAAVSK 18 1 P29590;P29590-4;P29590-2;P29590-5;P29590-9;P29590-3;P29590-8;P29590-11;H3BT57;P29590-14;P29590-10;P29590-12;P29590-13;H3BVD2;H3BT29;H3BUJ5 P29590 PML Protein PML 1 102735000.0 17725000.0 38099000.0 46911000.0 True False 23237646.64914418 32414777.70873883 42057099.72208672 1.0 1.3949251487535048 1.8098691471253454 24.4699606340072 -6.970500994373749 0.24592879850842103 0.861542154778465 2.3553428230120157 0.9999860297270609 0.0012358938122961098 0.07614047679848938 0.008446562419157755 0.009516077507813083 0.04003855278903085 1.070283932354196e-07 6.970500994373749 1.4938006682335507 LQDLSSCITQGK(ub)DAAVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQDLSSCITQGKDAAVSK 18 1 P29590;P29590-4;P29590-2;P29590-5;P29590-9;P29590-3;P29590-8;P29590-11;H3BT57;P29590-14;P29590-10;P29590-12;P29590-13;H3BVD2;H3BT29;H3BUJ5 P29590 PML Protein PML 1 143064000.0 53146000.0 29709000.0 60209000.0 True False 51458909.320649646 41571958.63038835 44438456.66871744 1.0 0.8078670764540705 0.8635716779734581 25.616917543468144 -10.08045258116509 5.608471495161156 1.0000011437492244 0.8357193772137236 0.9206132580164661 0.022741308341404694 3.25236773169746e-07 5.3326048465664475e-08 0.02201933050729946 0.0073397257064147505 8.308974360356443e-11 10.08045258116509 -0.16428176653550086 LQDLSSCITQGK(ub)DAAVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQDLSSCITQGKDAAVSK 18 1 P29590;P29590-4;P29590-2;P29590-5;P29590-9;P29590-3;P29590-8;P29590-11;H3BT57;P29590-14;P29590-10;P29590-12;P29590-13;H3BVD2;H3BT29;H3BUJ5 P29590 PML Protein PML 1 156443000.0 17725000.0 60655000.0 78063000.0 True False 24278411.500114225 57975061.54073762 59626127.157950886 1.0 2.3879264728857925 2.4559319771670545 24.533170695530092 -10.712051868606197 0.5596648218362671 2.1585743133852103e-21 2.4497438142022654 0.9998172112021648 0.009070236749809616 2.258301702995199 0.27176717839565395 3.0982157895401756 0.012501001043793961 1.9406540877864903e-11 10.712051868606197 2.4497438142022654 LQDLSSCITQGK(ub)DAAVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQDLSSCITQGKDAAVSK 18 1 P29590;P29590-4;P29590-2;P29590-5;P29590-9;P29590-3;P29590-8;P29590-11;H3BT57;P29590-14;P29590-10;P29590-12;P29590-13;H3BVD2;H3BT29;H3BUJ5 P29590 PML Protein PML 1 125867000.0 53146000.0 30031000.0 42690000.0 True False 44193253.76700132 29869217.042313207 51616281.62374168 1.0 0.6758773001823247 1.1679674435350822 25.39732281890242 -6.729044168925082 1.726504629114084 0.8047354133284326 1.1676338265083819 0.5548663345333662 0.13626471677158655 0.33806115553667054 1.973694551080521 0.06255334278674339 0.15540260099513378 1.8661898846171506e-07 6.729044168925082 0.3628984131799493 LQDLTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQDLTLR 7 0 Q9Y4L1;A0A494C039;A0A087X054;A0A1W2PS94;A0A2R8Y358;Q9BXT5 Q9Y4L1 HYOU1;TEX15 Hypoxia up-regulated protein 1;Testis-expressed sequence 15 protein 0 5716710.0 3339100.0 567410.0 1810200.0 False True 3233102.098230928 793979.7720040594 1336054.315164048 1.0 0.2455783170096933 0.41324222822876616 21.624487636418756 -10.461369041704659 9.060963690617395 1.000008829606343 0.3294102726572494 0.9552154713199619 0.0684485051276714 1.2209142746966097e-05 7.25797979061375e-07 0.06627584988337729 0.022091660036022035 3.456455407264852e-11 10.461369041704659 -0.6705985569490935 LQDSQLWK(ub)LPGLQATVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQDSQLWKLPGLQATVR 17 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 5874660.0 863060.0 2336600.0 2675000.0 True False 1131480.01788493 1987988.3879954612 2398216.660411886 1.0 1.7569805534096823 2.1195395610210253 20.10977967593263 -9.958778080219238 0.17647035822582172 1.2173855308271374e-14 2.531200066924211 0.9995780253487987 0.00958098500464503 1.4894940306962763 0.08063877465035076 0.9653498549394076 0.25627782868921045 1.0995675630292713e-10 9.958778080219238 2.531200066924199 LQDSQLWK(ub)LPGLQATVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQDSQLWKLPGLQATVR 17 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 9886400.0 2310900.0 3139800.0 4435700.0 True False 2237541.744422704 4393538.513840699 3273857.1018523783 1.0 1.9635559983593744 1.463149060799779 21.09348316741496 -10.215129865507443 4.85995897042381 0.9998906377202593 1.7133525295810255 0.7304270348067861 0.20429027679996056 0.00024211153460684882 3.91005615875402e-05 0.1978332317431316 0.06593440331915058 6.093546568760736e-11 10.215129865507443 0.7134618918607661 LQDSQLWK(ub)LPGLQATVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQDSQLWKLPGLQATVR 17 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 9117360.0 863060.0 3305600.0 4948700.0 True False 1182156.6053195253 3159547.661842593 3779918.981675721 1.0 2.6726980567761562 3.1974773601624853 20.17298973745552 -9.782484271809212 0.30629036524885517 3.516890380727667e-12 3.379240052951759 0.9987859706529635 0.032648847685698645 1.1598658162278763 0.1315601366709861 1.267769702798557 0.1809984427011374 1.650120760182633e-10 9.782484271809212 3.3792400529482425 LQDSQLWK(ub)LPGLQATVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQDSQLWKLPGLQATVR 17 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 12714800.0 2310900.0 4451100.0 5952800.0 True False 1921615.7402281105 4427121.040825829 7197502.957362592 1.0 2.3038534438213416 3.7455474612776607 20.873888442849236 -6.969830548637865 0.2622029286784382 0.6059758010422185 5.486321401186758 0.9999810304384769 0.004883869383195728 0.07635773769835519 0.009226752087006351 0.029672898091506823 0.1355816786383366 1.0719374681206848e-07 6.969830548637865 4.8803456001445396 LQEALNLFK(ub)SIWNNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQEALNLFKSIWNNR 15 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJR6;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 113337000.0 10434000.0 74761000.0 28142000.0 True False 15829140.8275767 61419315.43964087 22579721.36492322 1.0 3.880142081536059 1.4264653786885269 23.91607961536363 -6.607042765293578 2.1642562912866397 2.9280067085683603 1.434946971235399 0.041385372500468476 1.242650888076794 0.6208840110294805 5.506388643910898 0.4748159708132076 1.3805822539429442 2.471480764524541e-07 6.607042765293578 -1.4930597373329613 LQEALNLFK(ub)SIWNNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQEALNLFKSIWNNR 15 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJR6;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 81948000.0 10434000.0 48847000.0 22667000.0 True False 13507018.684888624 46128621.510036044 18541838.583060518 1.0 3.4151593764835613 1.3727558253698684 23.687205937456078 -6.605030052805006 2.1709898718115155 2.618780466790054 1.3795286879083106 0.03563313601777707 1.0425350765502734 0.6263819003876522 5.586381463037593 0.39745942338401835 1.1591593239312676 2.482961280563299e-07 6.605030052805006 -1.2392517788817432 LQEAQLYK(ub)EEGNQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQEAQLYKEEGNQR 14 1 E9PKV8;Q8N5M4;E7EST3;Q8N5M4-2 E9PKV8 TTC9C Tetratricopeptide repeat protein 9C 1 11353000.0 0.0 0.0 11353000.0 True False 0.0 0.0 8379308.717300542 0.0 LQEAQLYK(ub)EEGNQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQEAQLYKEEGNQR 14 1 E9PKV8;Q8N5M4;E7EST3;Q8N5M4-2 E9PKV8 TTC9C Tetratricopeptide repeat protein 9C 1 86560100.0 8126100.0 40292000.0 38142000.0 True False 12327887.797486188 33101577.797167163 30603216.981767554 1.0 2.685097264100424 2.482437988120555 23.55542230051927 -9.919462999032577 6.950384110003823 0.9999999510852204 2.5837676261104976 0.9878686117234676 0.08273530296545524 6.269691879252025e-08 9.789549104095263e-09 0.08010811501950278 0.02670270421071505 1.2037519425312663e-10 9.919462999032577 1.5837676750252772 LQEDTDKANK(ub)QSSVLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQEDTDKANKQSSVLER 17 2 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 12830400.0 4324000.0 5362900.0 3143500.0 True False 5668805.873675562 4562776.224420475 2818240.774581218 1.0 0.8048919518674652 0.4971489300186454 22.43461343472761 -6.964408687958426 0.3680590986764632 1.024192565933915 0.26716881621533306 0.9999004325430378 0.002065486469336309 0.07816218460896292 0.015570920102635449 0.004068652139745546 0.026163971275196492 1.0854037358445377e-07 6.964408687958426 -0.757023749718582 down LQEDTDKANK(ub)QSSVLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQEDTDKANKQSSVLER 17 2 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 64573200.0 30927700.0 2467000.0 31178500.0 True False 46919582.017734654 2026744.5752410248 25016055.808978006 1.0 0.043196134494014805 0.533168769481417 25.483686825411986 -10.698246737748274 5.984749741320211 1.0111288664814895 0.28818245198771597 0.7378118050286664 0.20003049060768133 0.029472474576003594 0.0014860111806010222 0.19217793630693816 0.06455956323810409 2.0033335407667716e-11 10.698246737748274 -0.7229464144937735 LQEDTDKANK(ub)QSSVLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQEDTDKANKQSSVLER 17 2 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 13379700.0 4324000.0 4070800.0 4984900.0 True False 5922699.65170628 3890938.595664571 3807569.28723812 1.0 0.6569535557224524 0.6428773213480766 22.4978234962505 LQEDTDKANK(ub)QSSVLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQEDTDKANKQSSVLER 17 2 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 102821500.0 30927700.0 27526300.0 44367500.0 True False 40036517.32610978 25994437.207437646 36293070.24899362 1.0 0.6492681917286895 0.9064991830676822 25.254813147504436 -10.446480190690783 5.373010460389948 1.00023578313053 0.777883687398184 0.4985338691120895 0.10501411246847499 0.00029691825174860945 3.05881621978904e-05 0.10178654355749824 0.03389315905892876 3.5770071587124506e-11 10.446480190690783 -0.22235209573234593 LQEEHSLQDVIFK(ub)SAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQEEHSLQDVIFKSAFK 17 1 F8W0R1;F8VR88;F8VUZ2;F8VPA6;A0A087WU02;Q96RQ1 F8W0R1 ERGIC2 Endoplasmic reticulum-Golgi intermediate compartment protein 2 1 18659100.0 1161800.0 2858500.0 14638800.0 True False 966088.1764667532 2843100.6931321756 17699705.397836227 1.0 2.9428997915388706 18.32100405427676 19.88179534667148 -6.9302958828208245 0.7443669528838219 0.7686899041857251 21.501889310610764 0.9965959301482227 0.45205020611198643 0.09248465260315054 0.07693174842284185 0.41256501088478587 1.3891983514538369 1.1740973752824834e-07 6.9302958828208245 20.73319940642504 LQEEITK(ub)QSPTLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQEEITKQSPTLQR 14 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 20475200.0 4899000.0 5446200.0 10130000.0 True False 6422636.441983479 4633648.18912133 9081844.773821462 1.0 0.7214557808117718 1.4140368765784832 22.61473420327581 -6.797526257049077 1.4658539761654097 0.8458317037997043 1.4230402107240046 0.8248861201804756 0.11907156131471458 0.2242973606740666 0.9517109038379409 0.06390985911251705 0.1488693947813906 1.5939465092438586e-07 6.797526257049077 0.5772085069243003 LQEEITK(ub)QSPTLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQEEITKQSPTLQR 14 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 36684200.0 7239200.0 7946000.0 21499000.0 True False 7009395.558537732 11118879.237842597 15867766.943824926 1.0 1.586282175828891 2.2637853451568066 22.740858610949843 -6.969229513063921 0.27596747217132495 0.8433073272760147 3.0272922327999607 0.99997573419006 0.0025437285059008046 0.07655350690577778 0.009921574183470715 0.012812266870803684 0.0625092318581723 1.07342198749596e-07 6.969229513063921 2.183984905523946 LQEEITK(ub)QSPTLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQEEITKQSPTLQR 14 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 100947000.0 13354000.0 32595000.0 54998000.0 True False 20258994.308171254 26778167.584102593 44127621.193520226 1.0 1.321791554741782 2.178174322094647 24.27205922222886 -6.9541083374258275 0.5117581393460447 0.9844640883072 2.5531853681930654 0.9994854963718217 0.011278242503971737 0.08187679426932042 0.029450653541126345 0.012951251086701985 0.07068793220955898 1.1114544335620205e-07 6.9541083374258275 1.5687212798858654 up LQEEITK(ub)QSPTLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQEEITKQSPTLQR 14 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 23656400.0 4899000.0 5955400.0 12802000.0 True False 6710292.690497004 5692270.736125782 9778431.26546619 1.0 0.8482894858203538 1.457228725553839 22.6779442647987 -6.840744935220695 1.2789297225161318 0.9193004287522534 1.4775547479726996 0.9257295877253515 0.07053465177171932 0.1679287155586999 0.5332355572869503 0.04324049115779291 0.09963850878926632 1.4429625666887718e-07 6.840744935220695 0.5582543192204462 LQEEITK(ub)QSPTLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQEEITKQSPTLQR 14 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 33607200.0 7239200.0 12549000.0 13819000.0 True False 6019715.55093658 12481396.046218533 16708489.008163163 1.0 2.07341957283623 2.7756276632645154 22.52126388638412 -8.343441771669578 0.17138138006112644 4.082058488391667e-14 3.862838258577466 0.9998558575178551 0.008766230570117953 0.10352396337185465 0.03945634765663455 0.392554203705065 0.3782122819007827 4.534800943578169e-09 8.343441771669578 3.8628382585774252 LQEEITK(ub)QSPTLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQEEITKQSPTLQR 14 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 97828000.0 13354000.0 35158000.0 49316000.0 True False 17287016.246693727 33201426.3936342 40340994.02489141 1.0 1.9205990160380757 2.3336007468962103 24.04318554432131 -9.860644648296518 0.2017508297517343 1.9444797289128507e-17 2.704584936648254 0.9994200249457319 0.01342442639918272 1.3389612283074144 0.08927278093865731 0.9989345520075831 0.24307576092085012 1.3783368007472321e-10 9.860644648296518 2.704584936648254 LQEESDLELAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQEESDLELAK 11 0 O75822-3;O75822;O75822-2 O75822-3 EIF3J Eukaryotic translation initiation factor 3 subunit J 0 16768900.0 1615700.0 6629300.0 8523900.0 False True 2118198.3464610567 5640234.280809009 7641928.5950223785 1.0 2.662750771301627 3.6077492968446503 21.014406257831823 -8.724659804950116 0.2322126632502047 1.2764578795853327e-16 4.412492978399956 0.999400080095662 0.026402931848564532 0.2824404172105657 0.06924561949961681 0.6311908281876847 0.41285972612632477 1.88512518271617e-09 8.724659804950116 4.412492978399956 LQEESDLELAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQEESDLELAK 11 0 O75822-3;O75822;O75822-2 O75822-3 EIF3J Eukaryotic translation initiation factor 3 subunit J 0 5666200.0 1615700.0 4050500.0 0.0 False True 2213067.952650749 3871535.5167877 0.0 1.0 1.7493974878405727 0.0 21.077616319354714 -6.80140810537647 1.5236566599283867 1.4180126289888186 6.813754246501485e-21 0.8018616616844586 0.31899025664937686 0.2279413971251189 1.056122438930466 0.1665497217593693 0.3748950059618263 1.5797628425953215e-07 6.80140810537647 -1.4180126289888186 LQEETGAK(ub)ISVLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQEETGAKISVLGK 14 1 Q07666;Q07666-2 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 6055900.0 1297000.0 2084600.0 2674300.0 True False 1700379.5601658688 1773585.8057071578 2397589.0896970127 1.0 1.0430528849300846 1.4100317046054895 20.69742539124466 -6.928933866816201 0.7554818000197571 0.9941934022041894 1.4833677350737515 0.9963248062014558 0.011153766335868415 0.09319468145668906 0.08041674023264499 0.010098011008723713 0.033401879060399466 1.1777853098131729e-07 6.928933866816201 0.48917433286956213 LQEETGAK(ub)ISVLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQEETGAKISVLGK 14 1 Q07666;Q07666-2 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 5393300.0 1620800.0 1625800.0 2146700.0 True False 1569348.5911810666 2274990.4184349957 1584414.8703804342 1.0 1.4496399533024555 1.009600339455512 20.58173441551777 -10.538904420525682 3.487163444103401 0.9943395139453566 1.2296201463826786 0.266355121932232 0.17964542023265478 130482840.44040942 35679.25404918293 5933548.732946581 0.06149739792161037 2.89131613283657e-11 10.538904420525682 0.235280632437322 LQEETGAK(ub)ISVLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQEETGAKISVLGK 14 1 Q07666;Q07666-2 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 5827800.0 1620800.0 2889700.0 1317300.0 True False 1347767.0136144916 2874132.61253946 1592741.339492968 1.0 2.132514435734337 1.1817631114308809 20.362139690952045 -6.603211706448922 2.178318482413195 1.7600276431401742 1.1849175481763508 0.029990444285930784 0.489102286531877 0.6316003423662471 5.668561764497079 0.18604346123932486 0.5438281114124606 2.493378977925333e-07 6.603211706448922 -0.5751100949638235 LQEETGAK(ub)ISVLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQEETGAKISVLGK 14 1 Q07666;Q07666-2 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 1 11195000.0 2565800.0 3444400.0 5184800.0 True False 3321478.6794793145 3252716.112129057 4241219.600540529 1.0 0.9792976038729121 1.276907067549022 21.66339422313319 -6.8902172904632115 1.0210769154040331 0.9840923285912633 1.3026153543543475 0.9810376877007748 0.018683410103768797 0.11896779703866762 0.22080977058762866 0.01393772219847321 0.034774912178766285 1.2876051632932905e-07 6.8902172904632115 0.3185230257630842 LQEIEEFK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQEIEEFKER 10 1 A0A0A0MSK2;P0DJ07 A0A0A0MSK2 PET100 Protein PET100 homolog, mitochondrial 1 25550900.0 4986400.0 13554000.0 7010500.0 True False 6454993.096638732 12799707.98507645 5734660.933804464 1.0 1.9829158286383857 0.8884069816884294 22.621984121951854 -6.6699769120172245 1.9370297444778959 1.6273770485722336 0.8927860901370236 0.27917528136672687 0.417518309012424 0.4611391944366093 3.335581867684775 0.17351057825150418 0.46366254240121907 2.138075750960181e-07 6.6699769120172245 -0.73459095843521 LQEK(ub)AADTIEALQKAGIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQEKAADTIEALQKAGIK 18 2 H0Y547;E9PEJ6;P98196;H0Y8F0 H0Y547 ATP11A Phospholipid-transporting ATPase;Probable phospholipid-transporting ATPase IH 1 232113000.0 93437000.0 86121000.0 52555000.0 True False 141750760.15969726 70752034.68355581 42167481.214325234 1.0 0.49912984314049635 0.29747622634840964 27.07878123095554 -13.999999999998561 0.12575168354673433 3.3820898057917472 1.2248192393375116e-16 0.9996673268964408 0.0053869487648660576 11.919080370948954 0.10959280604323018 7.046792213137957 0.26380110381616206 1.000000000003313e-14 13.999999999998561 -3.3820898057917472 LQEK(ub)AADTIEALQKAGIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQEKAADTIEALQKAGIK 18 2 H0Y547;E9PEJ6;P98196;H0Y8F0 H0Y547 ATP11A Phospholipid-transporting ATPase;Probable phospholipid-transporting ATPase IH 1 38429900.0 16896000.0 17680000.0 3853900.0 True False 14049772.61971274 17584754.330794763 4659732.671579714 1.0 1.2516041936594913 0.331658938383231 23.74404344639672 -6.833805338152555 1.3107429037756666 1.1341282157661108 0.30490840416435294 0.9132912766866869 0.11431031319812261 0.17615739915569092 0.590526224498062 0.06844421568704129 0.15752437268740926 1.466204884063677e-07 6.833805338152555 -0.8292198116017578 down LQEK(ub)EDLQELNDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQEKEDLQELNDR 13 1 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 18640600.0 6334100.0 8948700.0 3357800.0 True False 8304066.439511659 7613588.841759388 3010367.066291971 1.0 0.9168506655405715 0.3625172183074445 22.985386555839156 -6.933648483331348 0.7162132680576526 1.0073962076647882 0.2373673244165538 0.9972079316252817 0.014951471884805254 0.09078724988516647 0.06872121552828173 0.01393016906513119 0.04919025245405219 1.1650686510003548e-07 6.933648483331348 -0.7700288832482344 down LQEK(ub)EDLQELNDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQEKEDLQELNDR 13 1 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 20349000.0 9305100.0 4960700.0 6083200.0 True False 9009714.693854215 6941533.3797087455 4489827.427911802 1.0 0.770449855026349 0.49833180966034835 23.103049990981333 -6.968873476168656 0.2838160371584744 1.0572603153814613 0.20318592372942645 0.9999722081265154 0.0010809713522420595 0.07667005620884251 0.01033298451306725 0.004918400814281128 0.024858947062782594 1.0743023452858521e-07 6.968873476168656 -0.8540743916520348 down LQEK(ub)EDLQELNDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQEKEDLQELNDR 13 1 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 31946000.0 19128000.0 12818000.0 0.0 True False 29018574.4441141 10530527.752508895 0.0 1.0 0.3628892167942049 0.0 24.79047331204751 -8.438728906675697 0.5188314514509302 1.0452022721664438 3.1674062373631226e-19 0.993043620112685 0.0344740169600479 0.19686689569229668 0.1819603657148525 0.07260896466283179 0.06811991855315766 3.6414226842785818e-09 8.438728906675697 -1.0452022721664438 LQEK(ub)EDLQELNDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQEKEDLQELNDR 13 1 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 15141400.0 6334100.0 4734000.0 4073300.0 True False 8675987.942616276 4524836.226755457 3111270.4322467986 1.0 0.5215355596023311 0.3586070488830789 23.048596617362048 -13.999999999999998 0.15038097385342483 3.31494223725976 0.18013612738946763 0.9995649729754768 0.005677453617740371 11.95917511070497 0.12214937135984295 8.088803118122993 0.16092299449865144 1.0000000000000041e-14 13.999999999999998 -3.1348061098702926 LQEK(ub)EDLQELNDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQEKEDLQELNDR 13 1 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 21891800.0 9305100.0 10183000.0 2403700.0 True False 7737602.935824393 10128142.157832766 2906302.5565469163 1.0 1.3089508781770638 0.3756076113819438 22.88345526641561 -6.817479172032537 1.3826616742832822 1.1669561861573206 0.3562971295819874 0.8785198706923332 0.1353108576962194 0.1967668370441149 0.7398107563762254 0.07691516761342639 0.17741451644081885 1.5223721413077246e-07 6.817479172032537 -0.8106590565753331 down LQEK(ub)EDLQELNDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQEKEDLQELNDR 13 1 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 34664600.0 19128000.0 11875000.0 3661600.0 True False 24761573.06924948 11214145.811036048 2995226.3711887053 1.0 0.45288503196763774 0.12096268531938993 24.56159963413996 -8.44299426519463 0.34283707265507896 1.1316010805854284 6.171084818384537e-25 0.9981252878563501 0.015692568410177514 0.1554818192906712 0.09543795989454851 0.1013344738164001 0.08882320564641473 3.605834044498382e-09 8.44299426519463 -1.1316010805854284 LQEK(ub)LSPPYSSPQEFAQDVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQEKLSPPYSSPQEFAQDVGR 21 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 38262100.0 9696100.0 15550000.0 13016000.0 True False 12711680.997165956 13230000.613425253 11669229.178288275 1.0 1.04077506479079 0.9179926070273402 23.599651489669718 -6.817173667753147 1.3839183776759227 1.0220424437463604 0.9154681309490439 0.8777938214364611 0.01784926428193829 0.19717669444281785 0.7427678774747041 0.010136906103479478 0.02338495506315796 1.5234434301355941e-07 6.817173667753147 -0.10657431279731655 LQEK(ub)LSPPYSSPQEFAQDVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQEKLSPPYSSPQEFAQDVGR 21 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 78452000.0 21255000.0 23287000.0 33910000.0 True False 20580271.65939878 32585620.54010073 25027953.721805826 1.0 1.5833425855299263 1.2161138655512276 24.29475869013053 -10.504092420621134 6.078602610421319 0.9996133306858809 1.399728225540577 0.6123692152869886 0.1499204971405365 0.0007863454990518311 6.415204652279448e-05 0.14529603887554493 0.0483866323900362 3.132619012177094e-11 10.504092420621134 0.4001148948546961 LQEK(ub)LSPPYSSPQEFAQDVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQEKLSPPYSSPQEFAQDVGR 21 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 163957000.0 26089000.0 34618000.0 103250000.0 True False 39578920.36138092 28440147.42833144 82842592.24391732 1.0 0.718568045026359 2.093098838662382 25.23822892312234 -6.853370641720755 1.2188120134808211 0.849272484535005 2.151692454566903 0.9450494760650039 0.13897669768090212 0.15379561948695855 0.437964567419155 0.08914395394642469 0.20676638741328213 1.4016170062332785e-07 6.853370641720755 1.302419970031898 up LQEK(ub)LSPPYSSPQEFAQDVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQEKLSPPYSSPQEFAQDVGR 21 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 47396100.0 9696100.0 20337000.0 17363000.0 True False 13281010.197250053 19438444.09453437 13262217.002209777 1.0 1.463626923391661 0.9985849574120372 23.66286155119261 -10.641036463419011 3.16531491095673 0.983115852022373 1.2311059405088223 0.2477178966322251 0.18985258805873392 107181628.82447296 72156280.17393263 14161928.08360948 0.0750458199805978 2.2854069122697862e-11 10.641036463419011 0.24799008848644932 LQEK(ub)LSPPYSSPQEFAQDVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQEKLSPPYSSPQEFAQDVGR 21 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 67905000.0 21255000.0 26144000.0 20506000.0 True False 17674474.25615498 26003157.0828223 24793709.790968508 1.0 1.471226623545361 1.4027975843374416 24.075163965564805 -10.61716459892997 6.34281258365402 0.9983698023361706 1.4370121039414014 0.9819431667664914 0.02793603827471776 0.0006460396006715052 3.899323317602911e-05 0.027134437678136572 0.009016317583082913 2.414545540900193e-11 10.61716459892997 0.4386423016052309 LQEK(ub)LSPPYSSPQEFAQDVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQEKLSPPYSSPQEFAQDVGR 21 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 116723000.0 26089000.0 35157000.0 55477000.0 True False 33772724.791073345 33200482.044513203 45380755.24208978 1.0 0.9830560681703896 1.3437102135769814 25.00935524521479 -6.895875243094746 0.9869518554678914 0.9832616670679879 1.3785526830328 0.9844008108092813 0.020753376324462874 0.1145063883328386 0.19502542939845274 0.015884854787979477 0.04053844334568275 1.2709391470626824e-07 6.895875243094746 0.3952910159648122 LQELSAEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQELSAEER 9 0 J3KQ32;Q9NTK5;Q9NTK5-2 J3KQ32 OLA1 Obg-like ATPase 1 0 5485160.0 880760.0 2310000.0 2294400.0 False True 1154684.889291974 1965357.0043094752 2056997.4974388897 1.0 1.7020721605827773 1.7814362312303167 20.13906776669628 -11.270481485229785 0.3797308212023217 1.4760004055243088e-23 1.7899092778605823 0.9995447688089829 0.007492488612788434 3.3771067067080196 0.19029824594878503 2.861554473089613 0.021489213599148675 5.364367402348292e-12 11.270481485229785 1.7899092778605823 LQEMEGTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQEMEGTVK 9 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 7738330.0 699030.0 3921900.0 3117400.0 False True 916435.0994161501 3336767.8074464607 2794841.352212339 1.0 3.6410301281261224 3.049688247419702 19.805673189281816 -10.10669119390415 5.322418650588341 0.9999587289557859 3.345359187774587 0.9544915643045204 0.24141431188394918 0.00011823057889552608 1.9842851806721076e-05 0.23375245103936854 0.07791613412104102 7.821837804871832e-11 10.10669119390415 2.3454004588188013 LQEMEGTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQEMEGTVK 9 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 5190630.0 699030.0 4491600.0 0.0 False True 957480.2815754501 4293146.2602650635 0.0 1.0 4.483796003820639 0.0 19.868883250804707 -6.69932180441633 1.833386162305158 3.164713226026741 0.01354070052264557 0.41435831701125614 1.4707317964491624 0.3969126116302409 2.5933186463825377 0.6401058349503225 1.6475029167329835 1.9983805567619655e-07 6.69932180441633 -3.1511725255040957 LQEQLK(ub)QTEQNISSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQEQLKQTEQNISSR 15 1 Q6UWE0;Q6UWE0-2 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 1 5467400.0 1213400.0 2452100.0 1801900.0 True False 1590779.1505823152 2086256.2382109347 1615456.6730453013 1.0 1.3114681805122017 1.0155128525879615 20.601302128138514 -10.459369990238262 3.9718380687198054 0.9988627218042363 1.1634905164832232 0.2892097728783255 0.12082325770957757 0.001254593585634957 0.00017076975789388196 0.11780671072332877 0.03899553859021095 3.4724020965214695e-11 10.459369990238262 0.16462779467898692 LQEQLK(ub)QTEQNISSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQEQLKQTEQNISSR 15 1 Q6UWE0;Q6UWE0-2 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 1 12612600.0 3991100.0 2863700.0 5757800.0 True False 5166557.626342628 2704332.577605387 4709939.480017024 1.0 0.523430255343879 0.9116204290459369 22.300771931197357 -9.96889121374503 6.915577002306041 1.0000000209058237 0.7175253421949076 0.4138357303534764 0.15847797478873799 5.091911465661121e-08 7.935193997407735e-09 0.15344565070693847 0.05114854642478801 1.0742584692258005e-10 9.96889121374503 -0.28247467871091614 LQESPEDMPAGQTPHTVILFAHNDLVDK(ub)VQPGDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDR 34 1 A0A3B3IU45;P33991;A0A3B3IT92;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 76661000.0 21792000.0 20815000.0 34054000.0 True False 33060057.208601773 17100400.621662695 27323211.97360156 1.0 0.5172526022493816 0.8264720112611431 24.978585885347954 -10.095701032172233 5.1852131915876685 1.0000067154200598 0.6718623067547417 0.6002355183502962 0.12623829510911877 9.800448025386907e-06 1.7089559888320418e-06 0.12223220543444838 0.04074323455067421 8.022301276538142e-11 10.095701032172233 -0.32814440866531813 LQESPEDMPAGQTPHTVILFAHNDLVDK(ub)VQPGDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDR 34 1 A0A3B3IU45;P33991;A0A3B3IT92;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 14182000.0 3998000.0 6277200.0 3906800.0 True False 3324514.141430609 6243383.477673348 4723693.816997742 1.0 1.8779837329814117 1.420867415821861 21.664712083782895 -10.346724103745524 5.173633526766259 0.9997291559446239 1.6494255744016912 0.7290845227981062 0.18661695502371523 0.0005832358551831159 7.364532011042336e-05 0.18076453935211695 0.06023036324387139 4.500656793908482e-11 10.346724103745524 0.6496964184570674 LQESPEDMPAGQTPHTVILFAHNDLVDK(ub)VQPGDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQESPEDMPAGQTPHTVILFAHNDLVDKVQPGDR 34 1 A0A3B3IU45;P33991;A0A3B3IT92;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 78438000.0 21792000.0 23219000.0 33427000.0 True False 28210173.584540196 21926842.238858633 27343628.98998388 1.0 0.7772671860082078 0.9692825500715386 24.749712207440403 -10.16922000884663 6.4571532388091875 1.0000005475062068 0.8732748681045606 0.36739053520217524 0.07838994412165161 6.178817522720863e-07 7.952150990810337e-08 0.07590106501216745 0.025300245674440468 6.772983087533365e-11 10.16922000884663 -0.12672567940164625 LQEVGK(ub)AEAERPAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQEVGKAEAERPAR 14 2 Q9NPI8 Q9NPI8 FANCF Fanconi anemia group F protein 1 5122090.0 531490.0 2030100.0 2560500.0 True False 441957.48399923835 2019163.4483566987 3095888.7115856307 1.0 4.568682557619453 7.004946909307154 18.753548064475055 -8.15765495180266 0.2996135149069402 2.1663747107044477e-23 8.481269566923416 0.9989594270148093 0.07954791467856535 0.09417089760199275 0.06849407868616576 0.57994078198719 0.7285838455200907 6.955767357997616e-09 8.15765495180266 8.481269566923416 LQEVGK(ub)AEAERPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQEVGKAEAERPAR 14 2 Q9NPI8 Q9NPI8 FANCF Fanconi anemia group F protein 1 15377000.0 1924400.0 1179600.0 12273000.0 True False 2491173.735595136 1113954.2230482625 10039439.931614326 1.0 0.44716039155821513 4.030003924722627 21.248394208623193 -6.867518261527624 1.1472143713711938 0.6915978449740131 4.230106451738724 0.9621391203695377 0.30644569073394295 0.13925279221572487 0.344095514386401 0.20761299561137772 0.4894983012925186 1.3566934818743784e-07 6.867518261527624 3.5385086067647107 up LQEVIETLLSLEK(ub)QTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQEVIETLLSLEKQTR 16 1 O00232 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 1 23063000.0 2224100.0 6145900.0 14693000.0 True False 3374122.3034898667 5049116.126864124 11788922.109829323 1.0 1.496423565216295 3.4939225817736363 21.686080837982374 -6.9447383946387236 0.613899337814406 0.9780158995878439 4.117052368921924 0.9987209838334331 0.03854795852493925 0.08566987393207691 0.04525434192550214 0.03903980553904513 0.16866862558995271 1.1356947165136691e-07 6.9447383946387236 3.1390364693340804 up LQEVIETLLSLEK(ub)QTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQEVIETLLSLEKQTR 16 1 O00232 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 1 5539440.0 860640.0 2638100.0 2040700.0 True False 715660.292816619 2623888.031678147 2467400.93486928 1.0 3.666387611573824 3.447726469717005 19.448915410853076 -10.08714548999135 5.151071657498138 0.9999492353560507 3.557057040650729 0.9945455828476629 0.08926803737244232 5.2043384067114175e-05 9.22272451466973e-06 0.0864350887912933 0.028811135171679055 8.18190645827409e-11 10.08714548999135 2.5571078052946783 LQEYLGK(ub)FR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQEYLGKFR 9 1 Q6PKG0-3;Q6PKG0 Q6PKG0-3 LARP1 La-related protein 1 1 10400400.0 2941200.0 3985700.0 3473500.0 True False 3855941.6826213165 3391049.0961369174 3114095.540164739 1.0 0.8794347464901597 0.807609605248941 21.878651801693593 -13.99999999999859 0.0539637215940715 1.8245389278521955 0.43190949008031626 0.9999680934886027 0.0004483405231810111 12.525438613104493 0.05704672632299086 1.4754460137338892 0.3565545446765584 1.0000000000032476e-14 13.99999999999859 -1.3926294377718793 LQEYLGK(ub)FR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQEYLGKFR 9 1 Q6PKG0-3;Q6PKG0 Q6PKG0-3 LARP1 La-related protein 1 1 13826300.0 3521700.0 3520100.0 6784500.0 True False 3409905.561181119 4925694.287078996 5007435.9193627685 1.0 1.4445251338200815 1.4684969508739998 21.701300353059736 -11.706733329990557 0.46647774278413456 3.0912773466872335e-21 1.4681452662281047 0.999832984384987 0.002784012892358559 4.843779264767297 0.2313296624950799 4.837918280226031 0.005216473393801087 1.964566209911468e-12 11.706733329990557 1.4681452662281047 LQEYLGK(ub)FR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQEYLGKFR 9 1 Q6PKG0-3;Q6PKG0 Q6PKG0-3 LARP1 La-related protein 1 1 20386100.0 5996500.0 9759900.0 4629700.0 True False 9097128.902871735 8018169.5905532455 3714637.765730405 1.0 0.8813956223069578 0.4083307827547422 23.116979865057914 -6.944940860330944 0.6118792573511248 1.0052192630206866 0.2597920955949304 0.9987419876798148 0.009065334684875942 0.08558326690138864 0.04487718903239149 0.009198383173278528 0.039916525461194355 1.135165385295705e-07 6.944940860330944 -0.7454271674257562 down LQEYLGK(ub)FR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQEYLGKFR 9 1 Q6PKG0-3;Q6PKG0 Q6PKG0-3 LARP1 La-related protein 1 1 10285000.0 2941200.0 3802300.0 3541500.0 True False 4028641.122941378 3634301.813475337 2705070.639481996 1.0 0.9021160492006973 0.6714598190635007 21.941861863216484 -6.956716431571029 0.4794768268869771 1.0055637506357593 0.5584039791238683 0.9996283581976133 0.002655125268707845 0.08089564559453827 0.025628980493142026 0.003248742632111808 0.019027541821117357 1.1047997528818895e-07 6.956716431571029 -0.447159771511891 LQEYLGK(ub)FR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQEYLGKFR 9 1 Q6PKG0-3;Q6PKG0 Q6PKG0-3 LARP1 La-related protein 1 1 10830500.0 3521700.0 4764400.0 2544400.0 True False 2928449.5877629262 4738733.231540647 3076422.2760236203 1.0 1.6181713529720059 1.0505293616386724 21.481705628494012 -10.336370961104864 4.081895182137758 0.9993463615243885 1.3343503573172937 0.31627992190024046 0.2317388725970695 165085436.7608559 1013.1476098514704 1014200.5517288042 0.079330379977075 4.6092369939572424e-11 10.336370961104864 0.3350039957929052 LQEYNVGGK(ub)VIHLVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQEYNVGGKVIHLVER 16 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 39939900.0 12400000.0 17704000.0 9835900.0 True False 16256520.081770798 15062632.209651487 8818175.420615058 1.0 0.9265594440806508 0.5424393028925849 23.954515127154558 -6.938806623048995 0.6705833371329156 1.0044135950963338 0.44239558204126583 0.9980032316834796 0.008965588717044523 0.08831562569119357 0.057122874388099994 0.008650275059464411 0.03323814045289384 1.1513129163458187e-07 6.938806623048995 -0.5620180130550679 LQEYNVGGK(ub)VIHLVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQEYNVGGKVIHLVER 16 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 86082000.0 27081000.0 34874000.0 24127000.0 True False 26221328.478389952 48799370.065507464 17807414.90551486 1.0 1.8610563574505763 0.6791194778781199 24.64423744437964 -6.7113550806989775 1.790237354343824 1.5286247955720653 0.6817706509213289 0.4715645244186337 0.36276907715103107 0.3723768404647008 2.327224075974376 0.16120132932261422 0.40887661306946993 1.943770198399573e-07 6.7113550806989775 -0.8468541446507364 LQEYNVGGK(ub)VIHLVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQEYNVGGKVIHLVER 16 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 138389000.0 60319000.0 49019000.0 29051000.0 True False 91508332.90958384 40271176.46280495 23309057.116494395 1.0 0.4400820688384246 0.2547205962054325 26.44739978793555 -13.9999999999999 0.15449450291819136 3.7278900130498305 0.06096034426430472 0.9995519378876844 0.006706033350649756 11.97748562713996 0.12400284426334159 9.797916409603346 0.17545571495059512 1.0000000000002291e-14 13.9999999999999 -3.6669296687855257 LQEYNVGGK(ub)VIHLVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQEYNVGGKVIHLVER 16 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 63080000.0 12400000.0 34878000.0 15802000.0 True False 16984615.09740005 33336974.63387767 12069893.052405622 1.0 1.9627748078306928 0.7106368312257627 24.01772518867745 -6.701317119363509 1.826310352765432 1.597069881040146 0.7142829038067561 0.42380546607064296 0.4063013057271128 0.392769036122063 2.5478551340320745 0.1774275445925878 0.4555330752315982 1.9892202911920288e-07 6.701317119363509 -0.88278697723339 LQEYNVGGK(ub)VIHLVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQEYNVGGKVIHLVER 16 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 80142900.0 27081000.0 43417000.0 9644900.0 True False 22519051.391716447 43183104.00340029 11661603.997020995 1.0 1.9176253587344732 0.5178550283565975 24.424642719813917 -6.729847411331456 1.7236134794234272 1.552326906010674 0.5186902372434782 0.5585611687822398 0.38575500432816234 0.33656155472425536 1.9587397948204992 0.1773549797820592 0.44019945989723747 1.862741492933762e-07 6.729847411331456 -1.0336366687671958 LQEYNVGGK(ub)VIHLVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQEYNVGGKVIHLVER 16 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 144328000.0 60319000.0 56076000.0 27933000.0 True False 78084134.56524783 52955321.30523432 22849480.616783448 1.0 0.6781828549432709 0.2926264182090692 26.218526110027998 -7.225130634457878 0.3301682500769401 1.0561751591436357 4.9861643777150217e-11 0.9998557044015715 0.0034736499512738636 0.09306228027969743 0.01990306111979228 0.00992711323958075 0.04333863830375835 5.9548299711452325e-08 7.225130634457878 -1.056175159093774 down LQFHTGAVQGYGLVFGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQFHTGAVQGYGLVFGK 17 0 Q68CZ2;E9PCX8;Q68CZ2-3;C9JHU5 Q68CZ2 TNS3 Tensin-3 0 25935900.0 4776200.0 6389700.0 14770000.0 False True 6542090.211951799 6107381.926087736 11281630.197698465 1.0 0.9335520801792231 1.7244687603188291 22.641320222880932 -6.886491775040491 1.0428874838159512 0.9538608979792588 1.7880031827323908 0.9785571394858465 0.05245382443963668 0.12203680495025511 0.2388318938834588 0.03848819727777441 0.09481864879154353 1.2986981592110323e-07 6.886491775040491 0.834142284753132 LQFIFTNIDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQFIFTNIDPK 11 0 Q9HBM1 Q9HBM1 SPC25 Kinetochore protein Spc25 0 14246000.0 3382000.0 4776000.0 6088000.0 False True 4433834.75133459 4063439.41670219 5458072.16021965 1.0 0.9164616284986917 1.2310048674179306 22.080123571402943 -6.836073281758484 1.3005599407342672 0.9555135259061419 1.2405683223814523 0.9174794831874873 0.0382154922304608 0.17343659242726533 0.5715517755647591 0.02305497449244865 0.05306978026261193 1.4585681243932225e-07 6.836073281758484 0.2850547964753104 LQFIFTNIDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQFIFTNIDPK 11 0 Q9HBM1 Q9HBM1 SPC25 Kinetochore protein Spc25 0 14143800.0 3382000.0 4759300.0 6002500.0 False True 4632416.795113472 4549018.389099545 4584833.125367979 1.0 0.9819967827372743 0.9897281112969611 22.143333632925835 -10.23549392433724 4.904019501380319 1.0000025189608828 0.9858624470294932 0.8167956085726961 0.0031563016675694557 8.694257372586699e-08 1.3553207957373556e-08 0.0030566204439135608 0.0010186919828329688 5.814415664623673e-11 10.23549392433724 -0.014140071931389553 LQFIFTNIDPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQFIFTNIDPK 11 0 Q9HBM1 Q9HBM1 SPC25 Kinetochore protein Spc25 0 10493800.0 4539800.0 2411600.0 3542400.0 False True 3775044.847240293 2398608.2321348763 4283099.4617929775 1.0 0.6353853607562712 1.1345824050074775 21.848062352969002 -6.710878155760615 1.791990662607129 0.7760465870812676 1.1334449189673448 0.46931991977406984 0.15362537298738532 0.37330843985382917 2.3373380032373587 0.06820720453511245 0.173099531592951 1.9459059420532524e-07 6.710878155760615 0.35739833188607717 LQFK(ub)DHIVLTVLPDQDQSDEAQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQFKDHIVLTVLPDQDQSDEAQEK 24 1 Q8IUF8-4;Q8IUF8;Q8IUF8-3 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 1 49261000.0 19008000.0 10287000.0 19966000.0 True False 18404601.444453146 14394652.745996306 14736305.632839134 1.0 0.7821224919996638 0.8006859413562809 24.133563172404756 -10.667464069584062 6.610654023823101 1.001321373335055 0.7914042166779723 0.9940953269834955 0.007578496464951443 0.00014846432929743674 7.4681955578842785e-06 0.007381352599504764 0.0024459492165040593 2.150482587512833e-11 10.667464069584062 -0.20991715665708266 LQFK(ub)DHIVLTVLPDQDQSDEAQEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQFKDHIVLTVLPDQDQSDEAQEK 24 1 Q8IUF8-4;Q8IUF8;Q8IUF8-3 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 1 206426200.0 75286200.0 78616000.0 52524000.0 True False 114214669.55847272 64586360.57038844 42142608.37791304 1.0 0.5654821821055408 0.36897719479316043 26.7671727192575 -13.999999980302468 0.10800388625832018 3.1078077127478725 1.3426830423925687e-11 0.999757855722728 0.004102675478514924 11.955392297211551 0.09882003900093038 5.5156420119104155 0.3263989953462318 1.0000000453552457e-14 13.999999980302468 -3.1078077127344454 LQFK(ub)DHIVLTVLPDQDQSDEAQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQFKDHIVLTVLPDQDQSDEAQEK 24 1 Q8IUF8-4;Q8IUF8;Q8IUF8-3 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 1 45668000.0 19008000.0 15407000.0 11253000.0 True False 15805994.19717683 15323999.432949945 13605950.272006664 1.0 0.96950557122734 0.8608095196211621 23.913968447839032 -6.947525422283588 0.5853827768710157 1.0012747762264405 0.8236141081120233 0.9989924814682295 0.0018961926078804087 0.08449493024711315 0.04019426769600369 0.001975331798455056 0.009093693529548577 1.1284298807269459e-07 6.947525422283588 -0.17766066811441716 LQFK(ub)DHIVLTVLPDQDQSDEAQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQFKDHIVLTVLPDQDQSDEAQEK 24 1 Q8IUF8-4;Q8IUF8;Q8IUF8-3 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 1 180913200.0 75286200.0 47210000.0 58417000.0 True False 97459470.01286769 44582721.99907469 47785705.40903725 1.0 0.4574488450756851 0.4903136186019485 26.538299041349948 -9.978030263197217 5.3089073248106 1.000001814917139 0.47388123183732234 0.9970819957700353 0.013416987615670681 36906393.76867126 35.43645559932226 890.9796043281389 0.004592991730701482 1.0518885719007003e-10 9.978030263197217 -0.5261205830798167 LQFLFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQFLFAK 7 0 Q7Z3K3-5;Q7Z3K3-7;Q7Z3K3-2;Q7Z3K3-3;Q7Z3K3-6;Q7Z3K3;H0YCT3 Q7Z3K3-5 POGZ Pogo transposable element with ZNF domain 0 8928300.0 2226100.0 2721300.0 3980900.0 False True 2918438.6575830653 2315292.647544321 3568994.6554892263 1.0 0.7933326409066122 1.2229123426033992 21.47676531397716 -6.775888720084287 1.5519102047333397 0.8823545244796458 1.2258853850456146 0.7525647396048643 0.08725742769320699 0.2570160250810062 1.2223288412011004 0.044298505592904 0.10488987853111172 1.6753721040987413e-07 6.775888720084287 0.3435308605659688 LQFLFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQFLFAK 7 0 Q7Z3K3-5;Q7Z3K3-7;Q7Z3K3-2;Q7Z3K3-3;Q7Z3K3-6;Q7Z3K3;H0YCT3 Q7Z3K3-5 POGZ Pogo transposable element with ZNF domain 0 6394400.0 2226100.0 1598100.0 2570200.0 False True 3049149.3280905075 1527490.6577900066 1963171.6949305758 1.0 0.5009563302518145 0.6438424241294827 21.539975375500052 -10.596978608169143 9.765127646756447 1.0000496001504122 0.5723993771906638 0.9227253593927196 0.058333003556617066 6.299807906703095e-05 2.6000021672923255e-06 0.05648716915632329 0.01882689594241965 2.529422583908676e-11 10.596978608169143 -0.4276502229597484 LQFLFELPSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQFLFELPSR 10 0 Q9UID3;Q9UID3-2;E9PKX7;E9PJ36;E9PRV0;E9PMB6 Q9UID3 VPS51 Vacuolar protein sorting-associated protein 51 homolog 0 1172800.0 0.0 624090.0 548710.0 False True 0.0 530978.2046837668 491934.75279798376 0.0 LQFLFELPSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQFLFELPSR 10 0 Q9UID3;Q9UID3-2;E9PKX7;E9PJ36;E9PRV0;E9PMB6 Q9UID3 VPS51 Vacuolar protein sorting-associated protein 51 homolog 0 1956000.0 0.0 685100.0 1270900.0 False True 0.0 654830.0166772619 970739.5950071077 0.0 LQFSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQFSLK 6 0 P20290;P20290-2 P20290;P20290-2 BTF3 Transcription factor BTF3 0 152266000.0 41039000.0 37357000.0 73870000.0 False True 53802526.42224131 31783481.216445472 66226641.0110751 1.0 0.5907432853061445 1.230920654010363 25.68117058367115 -6.734001983400928 1.7084409633293567 0.7548216148911777 1.2308423719309356 0.5778303534224792 0.1719942210463997 0.3287726840466192 1.8816690543979757 0.07971879823747248 0.19694178422573339 1.8450069931066343e-07 6.734001983400928 0.4760207570397579 LQFSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQFSLK 6 0 P20290;P20290-2 P20290;P20290-2 BTF3 Transcription factor BTF3 0 110291000.0 32700000.0 17277000.0 60314000.0 False True 31661956.39907506 24175796.198364794 44515954.01878489 1.0 0.7635597716593103 1.4059761013405139 24.9162470668768 -6.807071269930655 1.426690736548859 0.8706854010368291 1.4164887459287343 0.8520558914025564 0.10204065419558397 0.2108324936393559 0.8463067703414363 0.05624568446848458 0.13029603755726352 1.5592965933374583e-07 6.807071269930655 0.5458033448919052 LQFSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQFSLK 6 0 P20290;P20290-2 P20290;P20290-2 BTF3 Transcription factor BTF3 0 71722000.0 24519000.0 30321000.0 16882000.0 False True 37197115.57900644 24909980.650945738 13545265.300356558 1.0 0.6696750611761036 0.36414827035678343 25.148687417232935 -7.312041653467481 0.2413493023576448 1.1285142688965486 6.675778099000855e-14 0.9999470853933463 0.0018887568573619094 0.1076194940700289 0.01599403707903403 0.016851408534506906 0.0485479796952162 4.874817331696815e-08 7.312041653467481 -1.1285142688964818 down LQFSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQFSLK 6 0 P20290;P20290-2 P20290;P20290-2 BTF3 Transcription factor BTF3 0 148732000.0 41039000.0 33131000.0 74562000.0 False True 56212227.33727429 31667162.8704341 56951991.25259267 1.0 0.563350081832385 1.0131601957502907 25.744380645194042 -10.94797083338165 11.781632990558673 1.051620752768253 0.7882551387913379 0.22807641287214553 0.18363421004034047 0.10481001447972045 0.0004628535261050591 0.07484394704857984 0.059267686440016135 1.127273159743886e-11 10.94797083338165 -0.26336561397691516 LQFSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQFSLK 6 0 P20290;P20290-2 P20290;P20290-2 BTF3 Transcription factor BTF3 0 75257000.0 32700000.0 23835000.0 18722000.0 False True 27191498.85562306 23706596.12412292 22636683.639252536 1.0 0.8718385201932524 0.8324912046755889 24.696652342311076 -13.999999991752986 0.16539381748051377 1.6389018972623703 0.7960239120645264 0.9995232246132495 0.0015615872668954423 12.049990290904038 0.12868037058861156 2.4693647413586706 0.033476279913561835 1.000000018989451e-14 13.999999991752986 -0.842877985197844 LQFSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQFSLK 6 0 P20290;P20290-2 P20290;P20290-2 BTF3 Transcription factor BTF3 0 74192000.0 24519000.0 31554000.0 18119000.0 False True 31740328.84174662 29797992.16180478 14821527.91663978 1.0 0.9388054014932834 0.4669620151239799 24.919813739325384 -6.93078834137082 0.7402917670171647 1.0069694864993488 0.36812097796830695 0.9966909424725353 0.013700398047294957 0.09223053157459998 0.07568971474212349 0.012540765663949566 0.042510110784323596 1.1727667882645269e-07 6.93078834137082 -0.6388485085310418 down LQGDANNLHGFEVDSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQGDANNLHGFEVDSR 16 0 C9JLU1;P52434;P52434-3;P52434-2;P52434-5 C9JLU1 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 0 40371700.0 4498000.0 25892000.0 9981700.0 False True 6823794.847847422 21271370.304880645 8008812.61986547 1.0 3.117234732165305 1.1736596422431815 22.702142843113702 -6.625848088751531 2.095593909254181 2.3990740763281155 1.1813533662729152 0.10270862918457246 0.9091410369647633 0.5699103220772671 4.763805401866914 0.3555085679383336 1.0073853739726861 2.3667474139225424e-07 6.625848088751531 -1.2177207100552003 LQGHQDQIFSLAWSPDGQQLATVCK(ub)DGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQGHQDQIFSLAWSPDGQQLATVCKDGR 28 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 91638600.0 5777600.0 13347000.0 72514000.0 True False 8765041.599138105 10965123.569413025 58181576.11598475 1.0 1.251006449358011 6.637912148837484 23.06332950739716 -6.916627608714464 0.8493539084650265 0.8660907285526875 7.442638380047035 0.9931918815443054 0.21457846654698212 0.10019710364515204 0.11619368103920079 0.1816524744984627 0.5277722877486327 1.211636621369894e-07 6.916627608714464 6.576547651494348 up LQGHQDQIFSLAWSPDGQQLATVCK(ub)DGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQGHQDQIFSLAWSPDGQQLATVCKDGR 28 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 78163600.0 5777600.0 13775000.0 58611000.0 True False 7479217.093522368 13008409.140801832 47944399.3996453 1.0 1.7392741751096128 6.4103500139298255 22.83445582948961 -6.934750236363946 0.7067111864853414 0.9399206005090008 7.496642791903839 0.9973922831072137 0.12231817511926046 0.09024519349865029 0.06613907193500274 0.11477426992465484 0.4121725788455482 1.1621167573972099e-07 6.934750236363946 6.556722191394838 LQGK(ub)EVGVYEALKDDSWLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQGKEVGVYEALKDDSWLK 19 2 P40925;P40925-3;A0A5K1VW95;P40925-2;B9A041;B8ZZ51 P40925 MDH1 Malate dehydrogenase, cytoplasmic 1 20495500.0 3500300.0 3442200.0 13553000.0 True False 4531207.351228249 3250638.5440630177 11086493.065523423 1.0 0.7173890515475716 2.446697360366497 22.111464080423563 -6.864968729308988 1.1602974588834165 0.8441109143380862 2.5387773115041323 0.9594031816839991 0.15261204789153615 0.14177479371222118 0.35990020039177784 0.10235374969300291 0.24043854206051235 1.3646813947885692e-07 6.864968729308988 1.694666397166046 up LQGK(ub)INDEDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQGKINDEDK 10 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 6002900.0 2391200.0 2524500.0 1087200.0 True False 2315292.664876705 3532546.01509358 802429.7046991237 1.0 1.525744917125497 0.34657808789017824 21.142763138394724 -6.785502123466213 1.5142733015503973 1.295568642350503 0.3355487909935394 0.7864073692094526 0.2229152172069652 0.24212860195365407 1.0968533954198147 0.11590338157907898 0.272271758047947 1.63869404893334e-07 6.785502123466213 -0.9600198513569637 down LQGK(ub)INDEDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQGKINDEDK 10 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 4930500.0 1221900.0 1232900.0 2475700.0 True False 1853711.632855658 1012879.3623083339 1986376.8098621406 1.0 0.5464061099665135 1.0715673218288602 20.82198540217309 -6.678235932925613 1.9083685109342579 0.7125502503092074 1.069532130874226 0.3159987337694202 0.19231875061189385 0.4424395641723435 3.1138154956441144 0.08091385469410865 0.2138716543436507 2.0977999323695576e-07 6.678235932925613 0.35698188056501867 LQGK(ub)INDEDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQGKINDEDK 10 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 2874180.0 1221900.0 796200.0 856080.0 True False 1581773.6372498926 751890.77008395 700282.224122578 1.0 0.47534663138728517 0.4427196203245014 20.59311172426554 -13.999999999999998 0.39504388924155703 9.56718777789708 0.4405779989563806 0.9998306409247162 0.0033232239485110403 26.052488756134903 0.20657900392735895 190.9576675762697 0.008464706562037851 1.0000000000000041e-14 13.999999999999998 -9.1266097789407 LQGK(ub)INDEDKQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQGKINDEDKQK 12 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 8258400.0 2996700.0 3567500.0 1694200.0 True False 2901571.39881065 4992021.354266732 1250438.1950894564 1.0 1.7204544255960594 0.4309520681110963 21.468402998971154 -6.755062610837024 1.6308736757319418 1.4210354776596823 0.4273270207749102 0.6705652130789379 0.30284948300661896 0.29129086713638197 1.525722048810634 0.1465961607901808 0.3540580166810787 1.7576701980393142e-07 6.755062610837024 -0.993708456884772 LQGK(ub)INDEDKQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQGKINDEDKQK 12 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 8192600.0 2940600.0 2863800.0 2388200.0 True False 4461105.186656311 2352732.515028472 1916171.2232147544 1.0 0.5273878145858948 0.4295283664115895 22.088969734579432 -13.999999999999996 0.22134922745811522 3.8689313489997246 0.37785509144016793 0.9994992801709728 0.0055736478472215144 13.036675358743622 0.1490335959272171 16.360058745295085 0.053679925652569585 1.0000000000000082e-14 13.999999999999996 -3.4910762575595564 LQGK(ub)INDEDKQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQGKINDEDKQK 12 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 6546990.0 2996700.0 2935200.0 615090.0 True False 2491888.8263194384 2919387.4950084183 743702.4751451687 1.0 1.1715560759267107 0.2984492996999508 21.24880827440543 -6.855695285984307 1.2073368637996322 1.0922057970072419 0.2595242071956877 0.9481887257342676 0.08597257139466724 0.15129801879967977 0.42155325403379573 0.055629338897274686 0.12928583050546721 1.394134626478544e-07 6.855695285984307 -0.8326815898115542 down LQGK(ub)INDEDKQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQGKINDEDKQK 12 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 6612040.0 2940600.0 2828400.0 843040.0 True False 3806664.6678918353 2670997.0536365774 689615.3703208774 1.0 0.701663342233872 0.18115999975978775 21.860096056671882 -7.258012125130292 0.4850331046055793 1.0131542185636548 2.286740803402845e-19 0.9989579055265081 0.010922974959166347 0.09522723315167869 0.04109442270479942 0.012596898194928988 0.05226554068421509 5.5206202596625136e-08 7.258012125130292 -1.0131542185636548 down LQGLAQSTIIEIVSVQVPAQTPASPAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQGLAQSTIIEIVSVQVPAQTPASPAK 27 0 F8VRI7;Q9H0E7 F8VRI7 USP44 Ubiquitinyl hydrolase 1;Ubiquitin carboxyl-terminal hydrolase 44 0 150270000.0 45595000.0 62837000.0 41838000.0 False True 69170948.44099657 51623246.402278095 33568700.961753175 1.0 0.7463139882535105 0.4853005736994856 26.043662902356292 -6.970768794327717 0.2391151473138869 1.094757011017519 0.12931641295834767 0.9999877720509884 0.0007347779783520286 0.07605403024576515 0.008132428426573373 0.00627847465037812 0.02548640178466574 1.0696241642757445e-07 6.970768794327717 -0.9654405980591714 down LQGLAQSTIIEIVSVQVPAQTPASPAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQGLAQSTIIEIVSVQVPAQTPASPAK 27 0 F8VRI7;Q9H0E7 F8VRI7 USP44 Ubiquitinyl hydrolase 1;Ubiquitin carboxyl-terminal hydrolase 44 0 93386000.0 45595000.0 23680000.0 24111000.0 False True 59023626.311816715 22362187.183607064 19723045.399751745 1.0 0.37886840543259004 0.3341550940221226 25.81478922444874 -13.999999999999998 0.3734919946519556 9.844161830366442 0.3297710875305721 0.9997968177096902 0.0043317343988828185 23.233189966666167 0.19868409879512539 164.76275902277234 0.012361452446198498 1.0000000000000041e-14 13.999999999999998 -9.51439074283587 LQGLPIVAGTMDIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQGLPIVAGTMDIR 14 0 Q9NTZ6;A6PVI1;A6PVI0;Q5JX62 Q9NTZ6 RBM12 RNA-binding protein 12 0 5720100.0 1001800.0 3040700.0 1677600.0 False True 1313369.501445 2587039.41255577 1504018.0446755083 1.0 1.9697727179666105 1.1451598678214716 20.3248414283635 -10.10102689003333 4.217273305608266 0.9999137791025258 1.5574662925453044 0.37863597192219 0.33664678668772313 236211752.33706656 490631378.35626966 297083.3270682352 0.1232001334348688 7.924522630196615e-11 10.10102689003333 0.5575525134427787 LQGLPIVAGTMDIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQGLPIVAGTMDIR 14 0 Q9NTZ6;A6PVI1;A6PVI0;Q5JX62 Q9NTZ6 RBM12 RNA-binding protein 12 0 5750300.0 1001800.0 2017300.0 2731200.0 False True 1372192.5326270475 1928169.015680982 2086146.8108296588 1.0 1.405173814777671 1.520301824435492 20.38805148988639 -12.083112681064891 0.207385480983674 3.426915476798397e-10 1.5969666490397945 0.9993949507021128 0.0054888070346305285 5.450599763134297 0.1293612654555834 2.39652805719534 0.06911608646188235 8.25823655438733e-13 12.083112681064891 1.5969666486971028 LQGVGALGQAASDNSGPEDAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQGVGALGQAASDNSGPEDAKR 22 1 Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 Q5JPE7-2 NOMO2;NOMO3 Nodal modulator 2;Nodal modulator 3 1 17683100.0 6012500.0 5439400.0 6231200.0 True False 7882445.725132817 4627862.722615131 5586455.197891046 1.0 0.5871100016406586 0.7087210483516416 22.910211900537725 -10.524658956475301 9.283395261088122 1.0000136103121138 0.6479155249961517 0.9178712282623119 0.0496475019212798 1.3985913101410247e-05 7.16145435139634e-07 0.04807284147686954 0.016023662343493117 2.9877279060987404e-11 10.524658956475301 -0.3520980853159621 LQGVGALGQAASDNSGPEDAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQGVGALGQAASDNSGPEDAKR 22 1 Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 Q5JPE7-2 NOMO2;NOMO3 Nodal modulator 2;Nodal modulator 3 1 23990300.0 3661800.0 4485500.0 15843000.0 True False 3545558.1633679816 6276583.541573487 11693243.020187832 1.0 1.7702666977577548 3.297997799331047 21.757581332511176 -6.960207695430145 0.43249629521820737 0.9408986649712862 4.186193959845422 0.9997778261089413 0.014234613062422262 0.07962700723934184 0.02085775104462761 0.019970804138237302 0.1267772002540958 1.0959539457243279e-07 6.960207695430145 3.245295294874136 LQGVGALGQAASDNSGPEDAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQGVGALGQAASDNSGPEDAKR 22 1 Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 Q5JPE7-2 NOMO2;NOMO3 Nodal modulator 2;Nodal modulator 3 1 25480300.0 6012500.0 7788800.0 11679000.0 True False 8235483.73170305 7444665.061882734 8920660.736555213 1.0 0.9039742296161661 1.0831981492737977 22.973421962060616 -6.761171401930751 1.6081484450368955 0.9443043225007764 1.0838892578334804 0.6957113572188891 0.04039556555551474 0.28094711577742215 1.432270497361421 0.01981722522131433 0.04756731824080577 1.7331198566247255e-07 6.761171401930751 0.139584935332704 LQGVGALGQAASDNSGPEDAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQGVGALGQAASDNSGPEDAKR 22 1 Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 Q5JPE7-2 NOMO2;NOMO3 Nodal modulator 2;Nodal modulator 3 1 21422600.0 3661800.0 7499800.0 10261000.0 True False 3044948.945245274 7459397.088806249 12406527.658496434 1.0 2.449760972332292 4.07446163518419 21.537986607945452 -6.969649662249766 0.2664199355599271 0.5781743188606125 5.994659520033872 0.9999795202071678 0.005683164612516901 0.07641653957140512 0.009436107526986317 0.03256067437860719 0.1518639865041493 1.0723840298216062e-07 6.969649662249766 5.41648520117326 LQGVGALGQAASDNSGPEDAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQGVGALGQAASDNSGPEDAKR 22 1 Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 Q5JPE7-2 NOMO2;NOMO3 Nodal modulator 2;Nodal modulator 3 1 87243300.0 6813300.0 18241000.0 62189000.0 True False 8819951.16022155 17225872.31487233 50871240.11302561 1.0 1.9530575625590683 5.767746236788432 23.07233923631998 -6.944859787109301 0.6126850317188244 0.9579558202254866 6.962422753258693 0.9987336427955897 0.07330618647634805 0.0856178249124071 0.04502730139550554 0.07432586098032602 0.3219711374130539 1.1353773154706951e-07 6.944859787109301 6.004466933033206 LQGVIK(ub)TR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQGVIKTR 8 1 Q13535;Q13535-2 Q13535 ATR Serine/threonine-protein kinase ATR 1 7025000.0 1752500.0 2641700.0 2630800.0 True False 2297544.471234141 2247568.6572659495 2358590.052415546 1.0 0.9782481625083207 1.0265699236492316 21.131661355890945 -6.784356314040268 1.519108384710045 0.9877530553391695 1.027004813801331 0.7824243644392366 0.009217021747698709 0.24387024505805058 1.1118334445923757 0.004777741928410345 0.011232138895409343 1.6430231625759904e-07 6.784356314040268 0.03925175846216156 LQGVIK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQGVIKTR 8 1 Q13535;Q13535-2 Q13535 ATR Serine/threonine-protein kinase ATR 1 8339100.0 2127800.0 2771800.0 3439500.0 True False 2060254.1536988323 3878594.194746048 2538591.7672117692 1.0 1.882580451437362 1.232174080393996 20.97439088909381 -10.145568062100137 4.662433274362608 0.9999421363251751 1.5573772659222644 0.4947431988654232 0.26552728910783013 0.00015973009941420033 2.927099050821097e-05 0.257122279439858 0.0856985640533278 7.152072988785493e-11 10.145568062100137 0.5574351295970893 LQGVIK(ub)TR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQGVIKTR 8 1 Q13535;Q13535-2 Q13535 ATR Serine/threonine-protein kinase ATR 1 5124000.0 1752500.0 1722300.0 1649200.0 True False 2400446.609531743 1646203.0911155283 1259692.9263401714 1.0 0.6857903377557956 0.5247743987881908 21.194871417413836 -13.999999999997573 0.08555388785383432 2.6428626723911752 0.08970922765833883 0.9998627768404283 0.0023116969865167505 12.204748170507816 0.08386710173654914 3.706423318374556 0.39260165114536155 1.0000000000055872e-14 13.999999999997573 -2.5531534447328363 LQGVIK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQGVIKTR 8 1 Q13535;Q13535-2 Q13535 ATR Serine/threonine-protein kinase ATR 1 9489900.0 2127800.0 5416900.0 1945200.0 True False 1769359.9775227725 5387718.084529534 2351932.3264113893 1.0 3.0450095814152616 1.3292559774660773 20.754796164528088 -6.602999300599668 2.178635926259991 2.3725418821400943 1.3348721841173052 0.029526538937518554 0.8832189073427714 0.6321694388364262 5.674763247413759 0.33590519827679194 0.9823453279394752 2.4945987443133266e-07 6.602999300599668 -1.037669698022789 LQHLAESWGGK(ub)ENGFGLAECCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQHLAESWGGKENGFGLAECCR 22 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 26376100.0 4999100.0 8707000.0 12670000.0 True False 7584000.18316452 7153167.821898497 10165768.946541732 1.0 0.9431919368590714 1.3404230882151609 22.85452756840351 -6.870642605886542 1.1307647530489424 0.9677466821014008 1.363965324474028 0.9653165853949154 0.032666839444405064 0.1362363445499014 0.3251901481457885 0.02241239738435481 0.05311936790233184 1.3469683592419147e-07 6.870642605886542 0.39621864237262716 LQHLAESWGGK(ub)ENGFGLAECCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQHLAESWGGKENGFGLAECCR 22 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 21035100.0 4999100.0 9963600.0 6072400.0 True False 6471433.496993162 9409116.901291687 4967285.508085621 1.0 1.4539463174061 0.7675711278488117 22.625653890495958 -6.7283624840145215 1.7291677894815485 1.2736808140532996 0.7680983318670583 0.551658006680599 0.1908542976456001 0.33932383516819636 1.9868988355004764 0.0874932056422096 0.21751484373964158 1.869121426393841e-07 6.7283624840145215 -0.5055824821862412 LQHLK(ub)ESHEMGQALQQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQHLKESHEMGQALQQAR 18 1 Q96R06;J3KTQ0 Q96R06 SPAG5 Sperm-associated antigen 5 1 20034500.0 7680200.0 10326100.0 2028200.0 True False 10068816.575162604 8785486.130822541 1818341.3198681816 1.0 0.8725440636682431 0.18059136406890167 23.26339079229565 -6.93798699216049 0.6780313071276373 1.0081037792124576 0.004547982393760185 0.9978881839845676 0.016544144034627204 0.08869708957976326 0.05888222151873856 0.015868712446190984 0.06010229708417095 1.1534878061752243e-07 6.93798699216049 -1.0035557968186974 down LQHLK(ub)ESHEMGQALQQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQHLKESHEMGQALQQAR 18 1 Q96R06;J3KTQ0 Q96R06 SPAG5 Sperm-associated antigen 5 1 33306300.0 6498500.0 8587200.0 18220600.0 True False 6292208.674599058 12016113.741656404 13448078.253716761 1.0 1.9096813794755585 2.13725878291436 22.585135086361483 -10.693776377197535 0.28095792393020713 5.845561770660758e-12 2.2223627079294723 0.9991456677197686 0.014361140291790605 2.391435132801515 0.14078942243369916 1.720071905209315 0.08887540810302573 2.0240611207890776e-11 10.693776377197535 2.222362707923627 LQHLK(ub)ESHEMGQALQQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQHLKESHEMGQALQQAR 18 1 Q96R06;J3KTQ0 Q96R06 SPAG5 Sperm-associated antigen 5 1 89109100.0 9081100.0 49271000.0 30757000.0 True False 13776692.617338201 40478205.09391987 24677865.46872802 1.0 2.938165655447474 1.791276480805742 23.71572624475932 -10.551858570293682 6.116402436517949 0.9975224119751218 2.3647210681264967 0.6537300381927293 0.46821554489899825 0.01582817243388206 0.001159709599103433 0.4536156087170197 0.15111591731910418 2.8063473872259626e-11 10.551858570293682 1.367198656151375 LQHLK(ub)ESHEMGQALQQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQHLKESHEMGQALQQAR 18 1 Q96R06;J3KTQ0 Q96R06 SPAG5 Sperm-associated antigen 5 1 19791600.0 7680200.0 6678600.0 5432800.0 True False 10519777.489600977 6383517.36882318 4149684.5320281824 1.0 0.6068110637447819 0.3944650479661032 23.32660085381854 -10.274124793300452 0.12823384955694117 1.8065696351886353 5.170665306311457e-21 0.9998205655897566 0.003360296659674033 1.9802502082921793 0.06411560709904691 0.7444416707196425 0.23278667805123984 5.31955381417511e-11 10.274124793300452 -1.8065696351886353 LQHLK(ub)ESHEMGQALQQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQHLKESHEMGQALQQAR 18 1 Q96R06;J3KTQ0 Q96R06 SPAG5 Sperm-associated antigen 5 1 21759300.0 6498500.0 13687200.0 1573600.0 True False 5403790.682362886 13613464.336903518 1902632.4844956612 1.0 2.5192434602131613 0.352092187934953 22.36554036179576 -6.718218775453872 1.765531275087805 1.9259780836250489 0.3557152689284719 0.5043498581376415 0.6394372277275895 0.3586998310195309 2.184123911147907 0.2876747600773772 0.7237413875547889 1.9132918631670183e-07 6.718218775453872 -1.570262814696577 LQHLK(ub)ESHEMGQALQQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQHLKESHEMGQALQQAR 18 1 Q96R06;J3KTQ0 Q96R06 SPAG5 Sperm-associated antigen 5 1 74515000.0 9081100.0 44971000.0 20462900.0 True False 11755662.965242678 42468324.31731385 16738862.167084709 1.0 3.6125843725596427 1.4238977603028924 23.48685256685177 -6.60271623912488 2.1807756909160014 2.75391784809377 1.4312198821675426 0.028387076744077144 1.1284597118475193 0.6329679518076619 5.693225232700436 0.4289366697697048 1.2544150552817568 2.496225186728768e-07 6.60271623912488 -1.3226979659262272 LQHNLAVSNHVFQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQHNLAVSNHVFQLR 15 0 E7EWM3;A0A087X127;Q8NF64-3;Q8NF64-2;Q8NF64 E7EWM3 ZMIZ2 Zinc finger MIZ domain-containing protein 2 0 14080300.0 4218600.0 5368600.0 4493100.0 False True 5530625.452980515 4567625.806638893 4028197.1128585613 1.0 0.8258787085604123 0.7283438640177164 22.399011211970254 -13.999999993914122 0.06812892080693465 2.0237432099222303 0.36031557705040007 0.9999306195067242 0.0009359065329695212 12.3797234323786 0.06980863249826771 2.0382359179121137 0.34001509942321045 1.0000000140132532e-14 13.999999993914122 -1.6634276328718303 LQHNLAVSNHVFQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQHNLAVSNHVFQLR 15 0 E7EWM3;A0A087X127;Q8NF64-3;Q8NF64-2;Q8NF64 E7EWM3 ZMIZ2 Zinc finger MIZ domain-containing protein 2 0 17296500.0 4218600.0 4926600.0 8151300.0 False True 5778330.423378384 4708926.521912421 6226130.8212931305 1.0 0.8149285653275743 1.0774965024677376 22.462221273493146 -6.717253647004402 1.7687953226007953 0.8870821205173136 1.0770378286164863 0.49978158131724126 0.07790548667480139 0.36064370332987095 2.2035063167538245 0.034989520715013885 0.08813514315548455 1.9175484812386585e-07 6.717253647004402 0.18995570809917273 LQHNLAVSNHVFQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQHNLAVSNHVFQLR 15 0 E7EWM3;A0A087X127;Q8NF64-3;Q8NF64-2;Q8NF64 E7EWM3 ZMIZ2 Zinc finger MIZ domain-containing protein 2 0 9445200.0 3098300.0 3813400.0 2533500.0 False True 2576373.727962596 3792856.4572993643 3063243.1364195226 1.0 1.472168581806944 1.1889746829711483 21.296910454845833 -10.36209405437345 5.149091686312831 0.999828355701887 1.3305716323890728 0.6449845800540638 0.11561342506960265 0.00022792587621779073 2.823715602524761e-05 0.11199987219236456 0.03731407249103416 4.3441613326412353e-11 10.36209405437345 0.33074327668718584 LQHVLVYFFQNEAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQHVLVYFFQNEAPK 15 0 Q96RU2-2;Q96RU2;H0YFT9;G3V1N5;B4E3L3 Q96RU2-2 USP28 Ubiquitin carboxyl-terminal hydrolase 28;Ubiquitin carboxyl-terminal hydrolase 0 3833200.0 1412000.0 2421200.0 0.0 False True 1851145.673827449 2059966.3977636793 0.0 1.0 1.1128062080087247 0.0 20.81998700026414 -6.9536542148818645 1.1975101408724298 1.0644966658229902 1.9506278072451978e-19 0.9730422758148763 0.08211342589692637 0.10615800094577803 0.3022820874442644 0.05707773232927201 0.10814770868051797 1.1126172401788364e-07 6.9536542148818645 -1.0644966658229902 down LQIAQLYPISIFIKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQIAQLYPISIFIKPK 16 1 A0A590UJD9;A0A590UJ08;Q12959-2;Q12959-4;A0A0C4DFT3;A0A590UJR4;A0A590UJ18;A0A590UJ81;A0A590UJR5;A0A590UK48;Q12959;Q12959-3;Q12959-8;Q12959-9;A0A590UJC5;A0A590UJX2;A0A590UKA8;Q12959-6;A0A590UJS9;A0A590UJ68;A0A590UJ29;Q12959-5;A0A590UK81;Q12959-7;C9JUA9 A0A590UJD9 DLG1 Disks large homolog 1 0 353018000.0 131030000.0 93668000.0 128320000.0 False True 126870524.37219585 131070120.87216695 94709142.48251607 1.0 1.033101435662478 0.7465023333920414 26.9187816881559 -6.8781469076723605 1.090124323079016 1.0200518674282295 0.7269027692386281 0.9721578073384397 0.02136093702250342 0.12928222632410843 0.28233650860807297 0.01511916918305114 0.036394731118345146 1.3238936293653365e-07 6.8781469076723605 -0.29314909818960144 LQIAQLYPISIFIKPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQIAQLYPISIFIKPK 16 1 A0A590UJD9;A0A590UJ08;Q12959-2;Q12959-4;A0A0C4DFT3;A0A590UJR4;A0A590UJ18;A0A590UJ81;A0A590UJR5;A0A590UK48;Q12959;Q12959-3;Q12959-8;Q12959-9;A0A590UJC5;A0A590UJX2;A0A590UKA8;Q12959-6;A0A590UJS9;A0A590UJ68;A0A590UJ29;Q12959-5;A0A590UK81;Q12959-7;C9JUA9 A0A590UJD9 DLG1 Disks large homolog 1 0 105923000.0 34128000.0 33629000.0 38166000.0 False True 51774671.09100416 27627642.205423724 30622473.37124792 1.0 0.5336130896295355 0.5914566471590501 25.625743147676456 -10.166387747775746 5.289554826530193 1.0000170414180654 0.5625348683947161 0.9870572448746643 0.023614533476392825 4.745950279878766e-06 7.479446093578443e-07 0.02286556334870343 0.0076215579067877536 6.817297588506201e-11 10.166387747775746 -0.43748217302334924 LQIAQLYPISIFIKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQIAQLYPISIFIKPK 16 1 A0A590UJD9;A0A590UJ08;Q12959-2;Q12959-4;A0A0C4DFT3;A0A590UJR4;A0A590UJ18;A0A590UJ81;A0A590UJR5;A0A590UK48;Q12959;Q12959-3;Q12959-8;Q12959-9;A0A590UJC5;A0A590UJX2;A0A590UKA8;Q12959-6;A0A590UJS9;A0A590UJ68;A0A590UJ29;Q12959-5;A0A590UK81;Q12959-7;C9JUA9 A0A590UJD9 DLG1 Disks large homolog 1 0 108698000.0 26180000.0 16601000.0 65917000.0 False True 35859453.487897925 15867512.927834237 50348762.20322888 1.0 0.4424917667300564 1.4040582693269685 25.095850165348455 -6.749517523410114 1.6516740416900237 0.671988728099133 1.4058941093776902 0.6468747161651256 0.23426298796644487 0.30088742696693255 1.6148409239612802 0.11205079825770595 0.2721623300186654 1.7802560755977267e-07 6.749517523410114 0.7339053812785572 LQIAQLYPISIFIKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQIAQLYPISIFIKPK 16 1 A0A590UJD9;A0A590UJ08;Q12959-2;Q12959-4;A0A0C4DFT3;A0A590UJR4;A0A590UJ18;A0A590UJ81;A0A590UJR5;A0A590UK48;Q12959;Q12959-3;Q12959-8;Q12959-9;A0A590UJC5;A0A590UJX2;A0A590UKA8;Q12959-6;A0A590UJS9;A0A590UJ68;A0A590UJ29;Q12959-5;A0A590UK81;Q12959-7;C9JUA9 A0A590UJD9 DLG1 Disks large homolog 1 0 289567000.0 131030000.0 62960000.0 95577000.0 False True 108957250.61321984 62620821.98341854 115561708.8018824 1.0 0.5747283602604113 1.0606151325542097 26.699186963590176 -6.675470336850154 1.9177546392278828 0.7298320941478698 1.0587119501975126 0.30346858161690016 0.18042306477417527 0.4487563407101063 3.1867907826847204 0.07559712118471493 0.2005634555297859 2.1112013900065947e-07 6.675470336850154 0.32887985604964287 LQIAQLYPISIFIKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQIAQLYPISIFIKPK 16 1 A0A590UJD9;A0A590UJ08;Q12959-2;Q12959-4;A0A0C4DFT3;A0A590UJR4;A0A590UJ18;A0A590UJ81;A0A590UJR5;A0A590UK48;Q12959;Q12959-3;Q12959-8;Q12959-9;A0A590UJC5;A0A590UJX2;A0A590UKA8;Q12959-6;A0A590UJS9;A0A590UJ68;A0A590UJ29;Q12959-5;A0A590UK81;Q12959-7;C9JUA9 A0A590UJD9 DLG1 Disks large homolog 1 0 84880000.0 34128000.0 29690000.0 21062000.0 False True 44179368.763453975 28037725.400392495 17228932.11436982 1.0 0.6346339068471671 0.38997687374433304 25.396869469768905 -8.256929856021857 0.1693912952423327 1.342646729706956 4.985868991598747e-10 0.9998813210060471 0.0027306901829919094 0.08767231716694937 0.035813326101872024 0.1216080900399848 0.12517751847224545 5.534394893811299e-09 8.256929856021857 -1.342646729208369 down LQIELGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQIELGK 7 0 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 0 51466000.0 12155000.0 16638000.0 22673000.0 False True 16649031.976524005 15902878.145491594 17318104.365092564 1.0 0.9551833504743984 1.0401868642880852 23.98893496143194 -6.763407621098587 1.5992919418970561 0.9740798266505843 1.0405550168549806 0.7049087579964739 0.01886053541392962 0.2772015913930591 1.3980421743313727 0.009300942156246886 0.022280221847365014 1.7242188110913466e-07 6.763407621098587 0.0664751902043963 LQILNLGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQILNLGAK 9 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 8153600.0 1895600.0 2125900.0 4132100.0 False True 2485149.9570165155 1808724.0066932957 3704549.929902041 1.0 0.727812823361659 1.4906746047427437 21.2449014777382 -6.8102318991457675 1.4135736941726937 0.8517027233140656 1.504090110990338 0.8604342018497442 0.11792812242794044 0.20648067416891316 0.8131344865362358 0.06559751486147422 0.15172354781449965 1.547989821910567e-07 6.8102318991457675 0.6523873876762724 LQILNLGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQILNLGAK 9 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 7805600.0 1895600.0 2928700.0 2981300.0 False True 2596454.54666384 2799300.3500842187 2277178.341800842 1.0 1.078124149595075 0.8770337785141539 21.30811153926109 -6.801401399105386 1.4506401819290085 1.0430283181179882 0.8741755510212984 0.8360959628706461 0.03351045287142827 0.21877107473558918 0.9088086473767601 0.018173560894529546 0.04222079016427957 1.5797872371020654e-07 6.801401399105386 -0.16885276709668984 LQILNLGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQILNLGAK 9 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 5628880.0 3360600.0 1283800.0 984480.0 False True 2794487.7998228353 1276883.914585653 1190330.2162787807 1.0 0.45692950052120634 0.4259564906149331 21.41415244581942 -13.925069898967589 0.40826435548053225 9.999999999999993 0.4244646024947397 0.9998480093912537 0.003249893590677952 26.266342994658824 0.211390376609303 209.56639920139588 0.007752155394520398 1.1883109553921321e-14 13.925069898967589 -9.575535397505254 LQILSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQILSLR 7 0 Q15404;Q15404-2 Q15404 RSU1 Ras suppressor protein 1 0 15892900.0 5459200.0 5440000.0 4993700.0 False True 7157064.066968 4628373.204953919 4476999.826952836 1.0 0.6466860100240337 0.625535804215521 22.770936463423887 -13.999999999999998 0.4006726803794702 6.981531334576598 0.6243138947610074 0.9998387169197254 0.0021812485298551994 26.86917706525356 0.20869098912775716 139.76011988722664 0.005401683793301252 1.0000000000000041e-14 13.999999999999998 -6.3572174398155905 LQILSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQILSLR 7 0 Q15404;Q15404-2 Q15404 RSU1 Ras suppressor protein 1 0 12154800.0 4795700.0 2581400.0 4777700.0 False True 4643463.128533461 3612166.481823166 3526277.042072298 1.0 0.7779035564268585 0.7594067066891942 22.14676974855254 -13.999999999999979 0.35212736551648804 3.76740051842239 0.7569227119107246 0.9997587389899772 0.0016979827908511305 20.87354730877382 0.19117684270850213 43.25195319489357 0.005479116375620389 1.000000000000049e-14 13.999999999999979 -3.0104778065116657 LQILSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQILSLR 7 0 Q15404;Q15404-2 Q15404 RSU1 Ras suppressor protein 1 0 19482100.0 5459200.0 7146400.0 6876500.0 False True 7477613.769332776 6830648.418015448 5252412.325962998 1.0 0.9134797047193498 0.702418243036865 22.834146524946778 -6.955985009425079 0.48874469762293205 1.004671900333872 0.6022951215562501 0.9995910920750654 0.0025273412824011036 0.08116778143115169 0.026677442351785166 0.003030666166650645 0.017407769072636324 1.1066619820523339e-07 6.955985009425079 -0.4023767787776219 LQILSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQILSLR 7 0 Q15404;Q15404-2 Q15404 RSU1 Ras suppressor protein 1 0 9255300.0 4795700.0 2100000.0 2359600.0 False True 3987837.0355324596 2088686.8831826365 2852981.450442276 1.0 0.523764352598163 0.7154207719677651 21.927175023986816 -10.175735303892326 5.362547578098546 1.0000144574050869 0.619592562282869 0.8400713781007261 0.07824340556439921 1.352470967867793e-05 2.078990154156969e-06 0.07576172795954411 0.025252950558407632 6.67213302020505e-11 10.175735303892326 -0.3804218951222179 LQILTALCHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQILTALCHR 10 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 0 9395100.0 2562300.0 3363800.0 3469000.0 False True 3359200.1133484994 2861934.1519896993 3110061.156997697 1.0 0.8519689376697722 0.9258338449797034 21.679686311290176 -10.088675228875749 4.423109346116594 1.0000103462739498 0.8889013913169824 0.7510168162790232 0.030155222160747105 31699282.567528535 0.40489287599038803 3340.503988993546 0.011035681310762591 8.153137584553457e-11 10.088675228875749 -0.11110895495696738 LQILTALCHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQILTALCHR 10 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 0 13294200.0 2064500.0 4902800.0 6326900.0 False True 3131997.4351669597 4027857.034248754 5076385.441821214 1.0 1.2860345889887481 1.6208140481924127 21.57865160051206 -6.9690524566197105 0.2798995238777372 0.926157211346359 1.9908913861989856 0.9999740165654195 0.0012932296192852012 0.07661141800731577 0.010126262726520048 0.006187356205437747 0.0307324319289472 1.073859697472064e-07 6.9690524566197105 1.0647341748526267 LQILTALCHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQILTALCHR 10 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 0 8380600.0 2562300.0 2378500.0 3439800.0 False True 3509651.5535538895 2273410.0053523104 2627390.0849047555 1.0 0.6477594629159823 0.7486185009575232 21.742896372813068 -10.265289454557506 8.004937480044214 1.0000003966642932 0.6981889819367533 0.9227161323002999 0.04117552985828882 2.915055659812373e-07 2.671718225407676e-08 0.03986808822412994 0.01328934511770157 5.428883791751137e-11 10.265289454557506 -0.3018114147275399 LQILTALCHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQILTALCHR 10 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 0 8147700.0 2064500.0 2764000.0 3319200.0 False True 2672535.947379004 2610180.970248726 2715139.6578680263 1.0 0.976668236327586 1.0159413049357873 21.34977792260451 -6.745737318704276 1.6654077384840509 0.9862110613807138 1.0159957375502817 0.6305410168612566 0.00980280786206826 0.3075271301825517 1.67674974653716 0.004652335400535487 0.011346566520634592 1.7958194927096595e-07 6.745737318704276 0.029784676169567925 LQIMLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQIMLQR 7 0 Q6VY07;Q6VY07-2;E9PPK2;F8W0B1;E9PNG7;F8VW41;Q86VP3-4;Q86VP3;Q86VP3-3;Q86VP3-2 Q6VY07 PACS1;PACS2 Phosphofurin acidic cluster sorting protein 1;Phosphofurin acidic cluster sorting protein 2 0 6251800.0 1339900.0 2113300.0 2798600.0 False True 1835297.2394359966 2019927.4182514367 2137628.3189762337 1.0 1.1005996058012808 1.1647313977506697 20.80758230603446 LQINQSIIFCNSSQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQINQSIIFCNSSQR 15 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 6465700.0 1593400.0 1440800.0 3431500.0 False True 2182523.0400159108 1377140.6919115453 2621050.373960888 1.0 0.6309856375681174 1.2009267833166977 21.057565453209243 -6.731912776430406 1.7160590861631289 0.7784028071418228 1.2007192658323835 0.5681611384969198 0.1551034336148096 0.33268246754087866 1.9201454459546985 0.07159696272408055 0.1772929113361218 1.85390392351858e-07 6.731912776430406 0.4223164586905608 LQISHEAAACITGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQISHEAAACITGLR 15 0 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 0 45106900.0 9528900.0 22974000.0 12604000.0 False True 12492480.17799887 19546368.75195058 11299858.986105198 1.0 1.5646507717798637 0.9045328729843368 23.574556593141818 -6.680188384830295 1.9013526730641805 1.3571792347528648 0.9070410894782825 0.32516480263939473 0.23929798070996589 0.4379641123639542 3.061361739924078 0.10098702836971517 0.2662691115576693 2.0883900490104133e-07 6.680188384830295 -0.4501381452745823 LQISHEAAACITGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQISHEAAACITGLR 15 0 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 0 35248200.0 9528900.0 8957300.0 16762000.0 False True 13051991.838839969 8561536.86816997 12803160.824226266 1.0 0.655956345505262 0.9809353991569904 23.63776665466471 -10.568898670003575 8.963191757277416 1.0000248291722276 0.8184458726973984 0.2938555037650413 0.1326721430898821 6.583637737898536e-05 3.1664860990953045e-06 0.1284767849978034 0.042819750057730054 2.6983689449794978e-11 10.568898670003575 -0.18157895647482913 LQISNPDLK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQISNPDLKDR 11 1 Q13568-5;Q13568-4;Q13568;Q13568-3;Q13568-2 Q13568-5 IRF5 Interferon regulatory factor 5 1 24975400.0 2430500.0 3231900.0 19313000.0 True False 3146330.1623175927 3052041.9239315754 15798232.168114351 1.0 0.9700323127193478 5.021161592424027 21.585238638216914 -6.905234170609386 0.927597297766391 0.854892408607055 5.494624449454719 0.9889949319878449 0.19960246178095653 0.10765400738838453 0.15649353163523488 0.15966024667343665 0.4274465861702464 1.2438437531663923e-07 6.905234170609386 4.639732040847663 up LQISTNLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQISTNLQR 9 0 A0A1W2PQ90;Q92878;Q92878-2;Q92878-3;A0A494C1B7 A0A1W2PQ90 RAD50 DNA repair protein RAD50 0 20853000.0 5498300.0 7626100.0 7728600.0 False True 7208324.545612947 6488315.606304967 6928918.609966096 1.0 0.90011424502991 0.9612384356615989 22.781232537440896 -10.18895291659095 4.586494799245123 1.0000132135012536 0.9306763403451808 0.631681933049176 0.02495384633395815 3.3722577767854147e-06 5.963462071222772e-07 0.02416606248984033 0.008053819272572371 6.472127785839035e-11 10.18895291659095 -0.06933687315607284 LQISTNLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQISTNLQR 9 0 A0A1W2PQ90;Q92878;Q92878-2;Q92878-3;A0A494C1B7 A0A1W2PQ90 RAD50 DNA repair protein RAD50 0 9774000.0 3758000.0 1287600.0 4728400.0 False True 3638704.347025201 1801745.394745296 3489890.191040593 1.0 0.4951612505199278 0.9591024326814928 21.794993403024048 -10.491612937429343 9.0587750740308 1.0000067700021944 0.7271318416007104 0.31564556537503785 0.18940319449324255 2.589731954114099e-05 1.453489499573436e-06 0.18339339814169597 0.06112961816590107 3.2239408307993105e-11 10.491612937429343 -0.272874928401484 LQISTNLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQISTNLQR 9 0 A0A1W2PQ90;Q92878;Q92878-2;Q92878-3;A0A494C1B7 A0A1W2PQ90 RAD50 DNA repair protein RAD50 0 16207800.0 3128100.0 7490900.0 5588800.0 False True 4745556.39474244 6154090.368331168 4484171.23034194 1.0 1.2968111337058874 0.9449200172417956 22.17814581587023 -6.683102942894666 1.8906675740818968 1.187275627569314 0.9462216219009479 0.3383251153912499 0.12571233357372896 0.4317502246620851 2.9864601043856545 0.05329845140609714 0.14002480002906345 2.074421749082208e-07 6.683102942894666 -0.241054005668366 LQISTNLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQISTNLQR 9 0 A0A1W2PQ90;Q92878;Q92878-2;Q92878-3;A0A494C1B7 A0A1W2PQ90 RAD50 DNA repair protein RAD50 0 15695900.0 5498300.0 4756200.0 5441400.0 False True 7531170.095970555 4546055.35734987 4156253.389150743 1.0 0.6036320119475421 0.5518735251212141 22.844442598963788 -13.999999999999998 0.2869654347991135 4.357775572601928 0.5373329074324141 0.9996206756697159 0.003898511367708418 15.787742281587901 0.16981494232637107 31.239758452742777 0.019819549583415814 1.0000000000000041e-14 13.999999999999998 -3.8204426651695136 LQISTNLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQISTNLQR 9 0 A0A1W2PQ90;Q92878;Q92878-2;Q92878-3;A0A494C1B7 A0A1W2PQ90 RAD50 DNA repair protein RAD50 0 8107200.0 3758000.0 2342500.0 2006700.0 False True 3124943.507627873 2329880.4875501534 2426291.692067518 1.0 0.7455752341963943 0.776427377373392 21.575398678458324 -9.929139746914622 6.733174982932908 1.0000000147267027 0.761001305893628 0.9876562591609944 0.012595334709165662 2.781938260606243e-09 4.453275530405438e-10 0.012195381209885649 0.004065126797374092 1.1772271054162102e-10 9.929139746914622 -0.23899870883307472 LQISTNLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQISTNLQR 9 0 A0A1W2PQ90;Q92878;Q92878-2;Q92878-3;A0A494C1B7 A0A1W2PQ90 RAD50 DNA repair protein RAD50 0 19648800.0 3128100.0 10831000.0 5689700.0 False True 4049387.1140693943 10228245.328785824 4654232.981252018 1.0 2.5258749140699077 1.1493672622904136 21.94927213796268 -6.621540885174154 2.1107552305754944 2.011395814976004 1.1546503009122149 0.08790376786893961 0.655929655153623 0.581474140212858 4.924766159277874 0.25512988264099 0.7273268440797173 2.390336894630005e-07 6.621540885174154 -0.856745514063789 LQISWHKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQISWHKPK 9 1 Q9P2N5 Q9P2N5 RBM27 RNA-binding protein 27 0 23024800.0 7577800.0 5248000.0 10199000.0 False True 9934569.183519581 4465018.856543778 9143705.315716192 1.0 0.44944262544879965 0.9203927363941106 23.244025975120586 -10.206943922287564 7.890787262232236 1.000000174015221 0.6849176809214572 0.37375190426018357 0.1922645776871898 5.885291382395336e-07 5.906013782119853e-08 0.1861594794978468 0.06205312562067404 6.20949208315975e-11 10.206943922287564 -0.3150824930937637 LQISWHKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQISWHKPK 9 1 Q9P2N5 Q9P2N5 RBM27 RNA-binding protein 27 0 19728400.0 4326300.0 2037100.0 13365000.0 False True 4188963.9745968925 2850524.6533361594 9864305.558594372 1.0 0.680484403929606 2.3548317957410037 21.998162046296837 -6.857292060222816 1.1993910780468993 0.8277491780104305 2.4317987065899533 0.950259127883093 0.16187319414308718 0.14961581171675076 0.4105331506937752 0.10537626669034825 0.24527008815450266 1.3890182113131472e-07 6.857292060222816 1.6040495285795229 up LQISWHKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQISWHKPK 9 1 Q9P2N5 Q9P2N5 RBM27 RNA-binding protein 27 0 18717100.0 7577800.0 4721100.0 6418200.0 False True 10379517.442345014 4512506.191410043 4902353.346978215 1.0 0.4347510581754508 0.47231033371341785 23.307236036643477 -9.901808884510565 5.740160294555618 1.0000002715016547 0.4535306979103758 0.9964695648923075 0.015333510032139059 5.3287040965861445e-08 1.017484183460817e-08 0.014846614547612338 0.004948869082387679 1.2536927531968856e-10 9.901808884510565 -0.5464695735912789 LQISWHKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQISWHKPK 9 1 Q9P2N5 Q9P2N5 RBM27 RNA-binding protein 27 0 12013900.0 4326300.0 4284000.0 3403600.0 False True 3597510.1375866053 4260921.241692576 4115277.023531676 1.0 1.1844084043501877 1.1439236766939078 21.778567321731114 -10.098931399607617 4.523753759004293 0.9999868225931782 1.1641660404279954 0.9563778925588745 0.01652782088060245 2.2962731094799904e-06 4.573669064442913e-07 0.01600433606837374 0.005334331248084474 7.962851202806989e-11 10.098931399607617 0.16417921783481726 LQISWHKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQISWHKPK 9 1 Q9P2N5 Q9P2N5 RBM27 RNA-binding protein 27 0 13709200.0 3118200.0 6885600.0 3705400.0 False True 4036571.368911222 6502410.307071154 3031055.2206146573 1.0 1.6108746044108813 0.7508984590137988 21.94469896893003 -6.715941049114401 1.774146081360365 1.3732511056053585 0.7525533082194643 0.4932339059211388 0.25719379332048187 0.36324404813502736 2.232231378323595 0.11521332282399686 0.2905937976308511 1.923352786003514e-07 6.715941049114401 -0.6206977973858941 LQIWYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQIWYR 6 0 A0A087WTI3;A0A087WXF6;O75251 A0A087WTI3 NDUFS7 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial 0 7495700.0 2589700.0 1890700.0 3015300.0 False True 3395121.778690477 1608614.9298908787 2703305.6807999825 1.0 0.4738018353236605 0.7962323171343406 21.695031892354393 -10.388552326629073 6.1366441898347945 1.0000645707355562 0.6350170762290056 0.6307901601042503 0.13163169299265015 0.0001163068247711284 1.1588616549294278e-05 0.12747427945186354 0.042483946232801724 4.0874050142516417e-11 10.388552326629073 -0.3650474945065506 LQIWYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQIWYR 6 0 A0A087WTI3;A0A087WXF6;O75251 A0A087WTI3 NDUFS7 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial 0 7107700.0 2589700.0 2159700.0 2358300.0 False True 3547182.074011048 2064277.3128271545 1801318.1107130877 1.0 0.581948507225323 0.5078166480121532 21.758241953877285 -13.999999999999998 0.24330920788626767 3.812139359475565 0.4760530105881858 0.9995305770531054 0.0046943724898107315 13.74262338281294 0.15610459069439842 18.813503758193004 0.03553258272304787 1.0000000000000041e-14 13.999999999999998 -3.3360863488873793 LQIWYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQIWYR 6 0 A0A087WTI3;A0A087WXF6;O75251 A0A087WTI3 NDUFS7 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial 0 4101400.0 1588900.0 1329200.0 1183300.0 False True 1321240.750204875 1322039.3357744566 1430722.5590389676 1.0 1.000604420934987 1.0828628762904233 20.333461940890302 -6.908510901034919 0.9058160931906772 0.9973316236514875 1.0931616193368212 0.9903473613341824 0.0038238266238479588 0.10541093918214914 0.144169700751017 0.003107749449285439 0.00849280763113348 1.2344943282822192e-07 6.908510901034919 0.09582999568533368 LQK(ub)LNEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQKLNEVR 8 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 24891700.0 2312300.0 11636100.0 10943300.0 True False 3031447.692345051 9900039.237162555 9810992.291545939 1.0 3.2657793377606112 3.236404941546725 21.53157549826291 -10.124115912776665 4.5973537485590485 0.9997886302077735 3.251092139700774 0.9998723098871078 0.01199204719669712 4183716.30608093 4.007433991323027 9374.102911850992 0.004105196701397045 7.514223133642186e-11 10.124115912776665 2.2513035094930003 LQK(ub)LNEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQKLNEVR 8 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 51381300.0 14904500.0 20697000.0 15779800.0 True False 14431364.805810824 28961420.03342917 11646596.996147187 1.0 2.006838606267356 0.807033648782661 23.782704409325877 -6.684152020438492 1.8870854551148846 1.6346682442631937 0.8114444813179887 0.34313206865123036 0.4263441854934937 0.42943266653880136 2.9600933750369713 0.1810487858717207 0.4749878061675443 2.0694168433329645e-07 6.684152020438492 -0.8232237629452049 LQK(ub)LNEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQKLNEVR 8 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 73772800.0 30470600.0 29133400.0 14168800.0 True False 46226127.89924844 23934317.14970687 11368330.469594337 1.0 0.5177659959292416 0.24592867683774064 25.46220518545919 -8.872727383687634 0.2188557916845331 1.3415931630626925 2.6109582899105657e-18 0.9994807039261118 0.007105705473375911 0.3731615990706412 0.06842446998835638 0.22007279505548633 0.1268788598028301 1.340517896294907e-09 8.872727383687634 -1.3415931630626925 down LQK(ub)LNEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQKLNEVR 8 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 25693000.0 2312300.0 13023400.0 10357300.0 True False 3167219.797557916 12447983.125375351 7911119.055289255 1.0 3.9302555304097826 2.4978118226556685 21.5947855597858 -10.219705270763365 10.776357247141812 0.9999999915787422 3.214033676532725 0.7610692183708918 0.5847926948763345 1.2218869584339895e-07 9.395436177150021e-09 0.5662230878412328 0.18874103068664988 6.029686453838456e-11 10.219705270763365 2.214033684953983 LQK(ub)LNEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQKLNEVR 8 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 54714900.0 14904500.0 30251800.0 9558600.0 True False 12393752.131303782 30088827.548887853 11557259.066027109 1.0 2.427741593515523 0.9325068747208617 23.563109684760153 -6.656668328781694 1.9850733644439453 1.9215407766911208 0.9388109834755831 0.22144192764859638 0.6083893502773454 0.4923578198505373 3.7261547252649674 0.2479398214187053 0.6740581656255465 2.2046094832239768e-07 6.656668328781694 -0.9827297932155377 LQK(ub)LNEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQKLNEVR 8 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 64702900.0 30470600.0 28672900.0 5559400.0 True False 39444792.36532173 27077227.90949524 4547646.244261111 1.0 0.6864588779861456 0.11529142306397885 25.23333150755164 -7.365499896571133 0.5570170402399962 1.0050880875486663 2.33668623246161e-21 0.9969441966857389 0.020246033675334698 0.10627144867784488 0.06749897332254001 0.02024140044129137 0.06290063151429673 4.310226606546542e-08 7.365499896571133 -1.0050880875486663 down LQLCYQLTTVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQLCYQLTTVGK 12 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 20851000.0 5779900.0 9272500.0 5798600.0 False True 7577504.872631217 7889079.143921901 5198616.496098828 1.0 1.0411183201499534 0.6860591426177014 22.853291444043265 -6.878063458218869 1.0905856696227165 1.0248846060760497 0.6618166203122727 0.9720875969618368 0.026493269163234388 0.12935726789662608 0.2827935991838512 0.018745194685276575 0.04511431874285858 1.3241480392629952e-07 6.878063458218869 -0.36306798576377697 LQLCYQLTTVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLCYQLTTVGK 12 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 29143000.0 5779900.0 5534100.0 17829000.0 False True 7916885.225924405 5289585.163178577 13618157.399781054 1.0 0.6681396802188635 1.7201408143681844 22.916501505566156 -6.821890650014006 1.3636360886449193 0.8214622939493206 1.7440590465517973 0.8886841316603971 0.14650827069764827 0.1910361866333693 0.6974850988601503 0.08441657511068762 0.19447909757582374 1.506986458997106e-07 6.821890650014006 0.9225967526024768 LQLDNQYAVLENQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQLDNQYAVLENQK 14 0 Q9UKY7;D6R9V8 Q9UKY7 CDV3 Protein CDV3 homolog 0 16993600.0 3644400.0 6428000.0 6921200.0 False True 4777843.692419803 5468967.456147747 6205060.616838403 1.0 1.1446518153836707 1.2987157002818916 22.187928225994213 -6.970324954628793 0.2503022519628087 0.9512887759106751 1.4965928047423882 0.9999848054651972 0.0004754074174104359 0.07619740423289552 0.008652013342476 0.0034291707324134737 0.014758278836937196 1.0707178561309658e-07 6.970324954628793 0.5453040288317131 LQLDNQYAVLENQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQLDNQYAVLENQK 14 0 Q9UKY7;D6R9V8 Q9UKY7 CDV3 Protein CDV3 homolog 0 16602200.0 4743100.0 1815100.0 10044000.0 False True 4592532.886741679 2539878.8956214543 7413175.086458788 1.0 0.5530453364751958 1.6141800765020335 22.130858621715618 -6.7922697020567355 1.487163590128149 0.7509329869297318 1.6261968307645631 0.8086249179686045 0.19029519271287007 0.23198157941002304 1.0134935636883453 0.10070373834929305 0.23539738462514367 1.6133563321236604e-07 6.7922697020567355 0.8752638438348314 LQLDNQYAVLENQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLDNQYAVLENQK 14 0 Q9UKY7;D6R9V8 Q9UKY7 CDV3 Protein CDV3 homolog 0 17244800.0 3644400.0 7310400.0 6290000.0 False True 4991833.1662068395 6987402.355739982 4804431.546616343 1.0 1.3997668037150213 0.9624583568098495 22.251138287517104 -6.666238626096804 1.9509307031042564 1.2559954091908574 0.9642613300991788 0.26237822241769393 0.16996186337148553 0.46982567167243383 3.4438590729717564 0.07023000551716013 0.188546798750301 2.1565591472680553e-07 6.666238626096804 -0.2917340790916786 LQLDNQYAVLENQK(ub)SSHSQYN ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQLDNQYAVLENQKSSHSQYN 21 1 Q9UKY7;D6R9V8 Q9UKY7 CDV3 Protein CDV3 homolog 1 10261100.0 3220500.0 3859900.0 3180700.0 True False 3118266.9903125735 5401178.199112588 2347579.251045349 1.0 1.7321089617701966 0.7528474176003861 21.57231302818392 -6.706591579319457 1.8072589579937353 1.4516482492242673 0.7553664406063088 0.44889149397122186 0.30867754933446007 0.381997178929346 2.4299181888481645 0.13602773556989078 0.3470226445281659 1.9652075351917886e-07 6.706591579319457 -0.6962818086179585 LQLDNQYAVLENQK(ub)SSHSQYN ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQLDNQYAVLENQKSSHSQYN 21 1 Q9UKY7;D6R9V8 Q9UKY7 CDV3 Protein CDV3 homolog 1 10483300.0 3220500.0 5773300.0 1489500.0 True False 2677988.442340489 5742198.086989678 1800947.5633301297 1.0 2.1442206382232007 0.6725001254135924 21.352718303618197 -6.699255649625899 1.834203815540868 1.711057156016046 0.677032193021872 0.4137817280260794 0.4830576819278598 0.3970465506960045 2.596600193831262 0.21017832287126006 0.5408839585300658 1.9986849873314495e-07 6.699255649625899 -1.0340249629941738 LQLDSPEDAEFIVAK(ub)AIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQLDSPEDAEFIVAKAIR 18 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 24895400.0 7249900.0 6244500.0 11401000.0 True False 7019755.892894615 8737961.414637316 8414736.077331409 1.0 1.2447671326408751 1.1987220361677804 22.74298943201447 -10.138315781340152 4.580276320938702 0.999974933087947 1.2217445844085921 0.9686743678696171 0.0187978319339308 13134555.010832105 0.04672087605689587 3472.357004452199 0.0064349978618288145 7.272508184237334e-11 10.138315781340152 0.22176965132064508 LQLDSPEDAEFIVAK(ub)AIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQLDSPEDAEFIVAKAIR 18 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 192099000.0 62138000.0 47107000.0 82854000.0 True False 94267888.89629664 38700387.80132907 66477870.5838018 1.0 0.41053627332105697 0.7052016477947606 26.49026308389841 -10.518805202813985 6.379791343091433 1.000376381790418 0.5578689605579304 0.7501127866013806 0.12029663538778353 0.0006445350840385194 4.861398338823386e-05 0.1165722925737475 0.038825572121805936 3.0282714155933524e-11 10.518805202813985 -0.44250742123248765 LQLDSPEDAEFIVAK(ub)AIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLDSPEDAEFIVAKAIR 18 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 LQLDSPEDAEFIVAK(ub)AIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQLDSPEDAEFIVAKAIR 18 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 28126500.0 7249900.0 12137000.0 8739600.0 True False 6028613.075026951 12071615.571994131 10567009.952655252 1.0 2.0023868544491332 1.752809447404785 22.523394707448745 -10.141882111024433 5.56544153888887 0.9999852941327391 1.8775981509270812 0.9428119260715683 0.10188954976468904 1.8592284829007596e-05 2.8665537234746626e-06 0.09865578113841894 0.032884710782538566 7.213032499435758e-11 10.141882111024433 0.8776128567943421 LQLDSPEDAEFIVAK(ub)AIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQLDSPEDAEFIVAKAIR 18 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 214265000.0 62138000.0 59302000.0 92825000.0 True False 80438865.9230983 56001791.56935242 75931802.46493112 1.0 0.6962031466591241 0.9439690825268963 26.261389405990858 -9.967188319470186 6.261579038624314 1.000000061380863 0.820086115374654 0.4128174500425701 0.10115001975323247 8.668043092237647e-08 1.421732819087482e-08 0.09793811905911853 0.03264602849772987 1.0784789690419475e-10 9.967188319470186 -0.17991394600620902 LQLEIDQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQLEIDQK 8 0 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 0 47039000.0 10843000.0 19033000.0 17163000.0 False True 14215278.003761383 16193350.590052916 15387137.399121184 1.0 1.139151171420505 1.0824366146796232 23.760938977840134 -10.166571251570545 4.798088333198896 0.9999888916948707 1.1107938930505918 0.8357532441399038 0.0231536208357008 2.7515792068454217e-06 4.779225339277827e-07 0.022420644421154566 0.007472798991497194 6.814417663080815e-11 10.166571251570545 0.11080500135572113 LQLEIDQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQLEIDQK 8 0 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 0 29949000.0 10335000.0 0.0 19614000.0 False True 10006921.082092978 0.0 14476504.992612787 1.0 0.0 1.4466492614314674 23.2544948199168 -6.720759841664286 1.7567836216766206 0.39210338538032147 1.4444600442857685 0.5160260312809718 0.42076418403815624 0.3538359515784638 2.1346517576743813 0.19015144843386397 0.4768886693632953 1.9021298384243412e-07 6.720759841664286 1.052356658905447 LQLEIDQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLEIDQK 8 0 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 0 41761000.0 10843000.0 13042000.0 17876000.0 False True 14851950.12105719 12465761.315873379 13654056.967776416 1.0 0.8393349839089038 0.9193443861905789 23.824149039363025 -10.116970826295073 4.475086637899555 1.0000131371554968 0.8793396850454656 0.7520083392470851 0.0326637017197098 45549926.32124077 0.5993761166891138 6330.474054471948 0.011181653899627662 7.638870959225816e-11 10.116970826295073 -0.12067345211003122 LQLEIDQK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQLEIDQKK 9 1 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 1 3575750.0 0.0 2738100.0 837650.0 True False 0.0 2723349.311829702 1012798.742143997 0.0 LQLEIDQK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQLEIDQKK 9 1 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 1 8074300.0 4095500.0 3978800.0 0.0 True False 5301705.48437429 3757376.282353706 0.0 1.0 0.7087108654805169 0.0 22.33802509844406 -7.411439755377594 0.7554145831481297 0.9906466140013992 7.309455192081925e-18 0.9873978681136711 0.04714174953558973 0.11398878100827438 0.13931600563698263 0.0409044750651964 0.0733819758001106 3.8775753387264224e-08 7.411439755377594 -0.9906466140013992 down LQLFCFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQLFCFR 7 0 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88 Q16666 IFI16 Gamma-interferon-inducible protein 16 0 9855500.0 3769800.0 2137400.0 3948300.0 False True 4942244.306795134 1818508.2515199448 3539767.7907679435 1.0 0.36795191387436316 0.716226793139523 22.23673489757286 -10.665659334424687 6.843023832475418 1.0023598239166576 0.5420893535070554 0.6974208446627419 0.14218262407150978 0.005138159533881919 0.0002510431244155821 0.1381858937577918 0.04588924459575228 2.1594376326333566e-11 10.665659334424687 -0.4602704704096021 LQLFCFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLFCFR 7 0 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88 Q16666 IFI16 Gamma-interferon-inducible protein 16 0 13965200.0 3769800.0 2528000.0 7667400.0 False True 5163596.935014422 2416304.601021922 5856518.035059803 1.0 0.46794988676147964 1.1341934912360556 22.29994495909575 -6.694056416609871 1.85256072500724 0.6677066259037208 1.131975507851856 0.3892718825439434 0.2248385924699892 0.40797998254278234 2.7178820927078524 0.09699209226206613 0.25123848878090477 2.0227563973726266e-07 6.694056416609871 0.4642688819481353 LQLFGQDFSHAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQLFGQDFSHAAR 13 0 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4;K7ES92 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 0 11430500.0 1585400.0 3309600.0 6535500.0 False True 2078474.753035437 2815820.5807197564 5859269.1529427655 1.0 1.35475332409378 2.8190234903675386 20.987093793162433 -6.944153723513138 0.6197156126852792 0.9839708955999595 3.2673426587644747 0.9986589121062542 0.02883215549260471 0.08592171395034051 0.046356680816025356 0.02904371190339135 0.12390842352141443 1.1372246808547887e-07 6.944153723513138 2.2833717631645154 up LQLFGQDFSHAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLFGQDFSHAAR 13 0 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4;K7ES92 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 0 6686000.0 1585400.0 1610600.0 3490000.0 False True 2171565.2238240354 1539438.3664580325 2665733.8788062087 1.0 0.7089072663206247 1.2275633490353852 21.050303854685325 -6.754418234279248 1.6335611565102723 0.8297483171295312 1.2289478911729177 0.6677449486609384 0.12235533872104774 0.29239488767318206 1.5364318057417021 0.0591374903160111 0.14290643594558966 1.7602800449825925e-07 6.754418234279248 0.39919957404338646 LQLFGQDFSHAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQLFGQDFSHAAR 13 0 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4;K7ES92 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 0 4541500.0 1888900.0 1721400.0 931200.0 False True 1570704.0424583 1712126.4765288543 1125909.614617667 1.0 1.0900376074981095 0.7168184356713772 20.58297993792484 -6.843007747266466 1.2685068995056468 1.047892992417449 0.7038058698676701 0.9294770185967882 0.042230063013636146 0.16531817224544382 0.5154555380169111 0.026091888455739842 0.060162746982713504 1.4354638262588862e-07 6.843007747266466 -0.3440871225497788 LQLIK(ub)DYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQLIKDYR 8 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 9008400.0 3383000.0 3643200.0 1982200.0 True False 4435145.761018598 3099648.761082374 1777100.958605023 1.0 0.6988831772623619 0.4006860325142696 22.080550088786946 -7.061082511449067 0.23598122277543182 1.117579372760577 4.5348496565302896e-14 0.9999882767229622 0.0008377119140970513 0.07321419443890856 0.008303759188842543 0.007978575821799415 0.029055304650599544 8.687953514956089e-08 7.061082511449067 -1.1175793727605317 down LQLIK(ub)DYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQLIKDYR 8 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 10426300.0 4186900.0 3731800.0 2507600.0 True False 4053989.1512931935 5221927.2010799125 1850784.333612512 1.0 1.2880959978430517 0.4565341111043983 21.950910797399718 -6.813137768018097 1.401259037717995 1.1564370363182706 0.44091172525405536 0.8678766631529352 0.1253227411912765 0.20254977023796714 0.7832311367406299 0.07031130855998602 0.16242910697974636 1.537666780296471e-07 6.813137768018097 -0.7155253110642152 down LQLIK(ub)DYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQLIKDYR 8 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 16452000.0 5439600.0 6941300.0 4071100.0 True False 8252270.888028198 5702570.782375559 3266445.3005734845 1.0 0.6910304884257301 0.3958238095785499 22.976359749055664 -7.138281005099043 0.23173653826046448 1.1272685291027076 1.3539877195854642e-10 0.9999838070833694 0.0009926147662175705 0.0812637375841847 0.00964194050537404 0.010072165285211486 0.03322301908249566 7.273090555496532e-08 7.138281005099043 -1.1272685289673088 down LQLIK(ub)DYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLIKDYR 8 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 8881600.0 3383000.0 2952800.0 2545800.0 True False 4633786.52213745 2822335.5323961764 1944534.4723968015 1.0 0.6090775910613818 0.4196426536067174 22.143760150309838 -13.81221107444732 0.0977827467425295 2.8828645331781315 3.1280872511034022e-19 0.9998137603922286 0.003297683459507756 11.305060411298518 0.09032464342244532 4.382987224275288 0.3676667756460558 1.5409513425667133e-14 13.81221107444732 -2.8828645331781315 LQLIK(ub)DYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQLIKDYR 8 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 11576200.0 4186900.0 4697000.0 2692300.0 True False 3481592.861119518 4671696.3287185 3255247.4822112806 1.0 1.3418272943081289 0.9349879816689838 21.731316072833994 -6.683876268211783 1.8880698836943108 1.2155194149628354 0.936484322491872 0.34198482861478263 0.14475305429881083 0.429961425704202 2.9666037579240463 0.06144358472563413 0.1612556860157358 2.070731222236222e-07 6.683876268211783 -0.2790350924709635 LQLIK(ub)DYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQLIKDYR 8 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 18130400.0 5439600.0 7341100.0 5349700.0 True False 7041669.430546306 6932561.331654466 4376109.492557415 1.0 0.9845053648189538 0.6214590922962295 22.747486071148113 -6.915858642700739 0.8548698124843724 1.0092670342006616 0.5681482246140934 0.9929512306553806 0.014684757566402524 0.10067034792956397 0.11869135363564227 0.012382386073164928 0.035742170047178064 1.213783857297987e-07 6.915858642700739 -0.44111880958656813 LQLLEDDK(ub)ENR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQLLEDDKENR 11 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 15092900.0 4258100.0 3080700.0 7754100.0 True False 6459849.008808147 2530925.015381037 6221498.736257244 1.0 0.391793215589105 0.9631028105725216 22.623069013378128 -10.745075637911109 10.021805675207649 1.0008990778590985 0.6774480130808145 0.2982486083682032 0.23323616547758177 0.004696381027327323 0.00011946164017894198 0.2263620185084518 0.07527664871899602 1.798557646146118e-11 10.745075637911109 -0.323451064778284 LQLLEDDK(ub)ENR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLLEDDKENR 11 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 9292600.0 3051400.0 3305400.0 2935800.0 True False 4179585.0409844005 3159356.4985039 2242424.504698927 1.0 0.7559019537881659 0.5365184540355178 21.99492828458939 -6.972391712212146 0.19268183688853446 1.1435747251267303 0.1428356636235655 0.9999955224496325 0.0004005324097946191 0.07553405265771065 0.006166504801848613 0.007570842794750777 0.023740316642420257 1.0656345378272372e-07 6.972391712212146 -1.0007390615031648 LQLLEDDK(ub)ENR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQLLEDDKENR 11 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 5655170.0 2162500.0 2565200.0 927470.0 True False 1798214.5649934215 2551380.7584476634 1121399.688863239 1.0 1.4188411150240001 0.6236183994357434 20.77813374444972 -6.7636271675938024 1.5991242887984431 1.2421896638068755 0.6202113968755297 0.7054868027779695 0.17626731315343624 0.27686362846734663 1.3961978093443859 0.08694346218462269 0.2081717318018091 1.7233473965404715e-07 6.7636271675938024 -0.6219782669313457 LQLLEDDK(ub)ENR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQLLEDDKENR 11 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 15674900.0 4258100.0 4373500.0 7043300.0 True False 5512194.389699456 4130110.8803845206 5761491.670360886 1.0 0.7492680026129681 1.045226503827094 22.394195335470577 -6.6822076525270875 1.8939872812584406 0.8416712947557164 1.0441203620297754 0.33420280599575003 0.10621589095711562 0.43368364228374073 3.0096590312855347 0.044967662625574084 0.11826726452922681 2.0787025435807856e-07 6.6822076525270875 0.20244906727405898 LQLLEDDKENR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQLLEDDKENR 11 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 16779100.0 4207900.0 1792200.0 10779000.0 False True 4074322.517788006 2507834.806199532 7955656.5369314365 1.0 0.6155219168955389 1.9526329843054862 21.958128755910945 -6.8298209699804815 1.3287123212935568 0.7945304833232958 1.988479566269214 0.905506425698249 0.1727760387946817 0.18104013090245666 0.6251619148659475 0.10209778876114993 0.23495716866516775 1.4797182494550266e-07 6.8298209699804815 1.1939490829459183 LQLLLLNPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQLLLLNPLK 10 0 F8VZV1;A0A286YFF8;Q7Z3U7-2;Q7Z3U7-6;Q7Z3U7-5;Q7Z3U7 F8VZV1 MON2 Protein MON2 homolog 0 4416100.0 1240200.0 2010100.0 1165800.0 False True 1625914.2101138828 1710200.9153084324 1045174.1991432428 1.0 1.051839577186945 0.6428224765130974 20.6328197062522 -6.875092565708458 1.1067558415105099 1.030450498964713 0.6164258101952781 0.9695089797472303 0.03175050337320898 0.13206817117041986 0.29928402717663855 0.022187228816233445 0.05304796624971266 1.333237235132649e-07 6.875092565708458 -0.4140246887694349 LQLLLLNPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLLLLNPLK 10 0 F8VZV1;A0A286YFF8;Q7Z3U7-2;Q7Z3U7-6;Q7Z3U7-5;Q7Z3U7 F8VZV1 MON2 Protein MON2 homolog 0 7938900.0 1240200.0 2448900.0 4249800.0 False True 1698735.455144802 2340699.5005706446 3246084.7673784005 1.0 1.3779070151750736 1.9108830380547397 20.69602976777509 -6.966261254435634 0.335701632689669 0.9392355305675066 2.3671521408580483 0.9999368334438876 0.0029697334495809658 0.07753552317375456 0.013364899027866944 0.007626800085185331 0.04627987066467116 1.0807835989076822e-07 6.966261254435634 1.4279166102905416 LQLLSNLFHGMDK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LQLLSNLFHGMDK 13 0 Q7L2H7;J3KNJ2;E9PN86 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 0 45700100.0 7490700.0 17411200.0 20798200.0 False True 9820380.24004198 14813516.828326046 18646201.77442185 1.0 1.5084463601444744 1.8987250308692873 23.22734745535117 -6.97406886600688 0.12789447912205185 0.3763558400948153 3.04090062798783 0.9999992734357621 0.00031359012727166563 0.07500312051802224 0.003832810362503634 0.025133430098288462 0.05389759578086691 1.0615272176503217e-07 6.97406886600688 2.6645447878930146 LQLLSNLFHGMDK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LQLLSNLFHGMDK 13 0 Q7L2H7;J3KNJ2;E9PN86 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 0 81234700.0 35998300.0 27769400.0 17467000.0 False True 34855553.67097315 38857866.23550797 12891868.70123216 1.0 1.1148256774893193 0.3698655549393321 25.05488520883396 -6.867563932180124 1.1469727908667458 1.0640704487933554 0.32822273506148364 0.9621871811221919 0.06368122560548245 0.13920835677416843 0.3438127912018098 0.04315114509561202 0.10174685277098139 1.356550818724547e-07 6.867563932180124 -0.7358477137318717 down LQLLSNLFHGMDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQLLSNLFHGMDK 13 0 Q7L2H7;J3KNJ2;E9PN86 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 0 23267100.0 7843600.0 8935600.0 6487900.0 False True 11899314.643969765 7340972.365838541 5205563.721252411 1.0 0.6169239645712484 0.43746752455952936 23.5043751462977 -13.999999999990619 0.1012057110432822 2.8853325558378686 0.06228955369996467 0.9997876634503202 0.003418740679449401 12.0713687815815 0.09498286271362623 4.738965389047116 0.3343857060000525 1.0000000000216004e-14 13.999999999990619 -2.823043002137904 LQLLSNLFHGMDK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LQLLSNLFHGMDK 13 0 Q7L2H7;J3KNJ2;E9PN86 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 0 140434900.0 7490700.0 51701100.0 81243100.0 False True 10260214.218556017 49416774.44932535 62055153.0341663 1.0 4.816349190833959 6.048134250641377 23.29055751687406 -9.211754056936728 0.3945670176785085 6.6369448561845465e-18 6.254529131304304 0.9979076541350269 0.09830188730340864 0.6112341355316091 0.15235423894033173 1.2784777155182212 0.31394688017801764 6.141096799892099e-10 9.211754056936728 6.254529131304304 LQLLSNLFHGMDK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LQLLSNLFHGMDK 13 0 Q7L2H7;J3KNJ2;E9PN86 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 0 77895100.0 35998300.0 21659700.0 20237100.0 False True 29934181.445087895 21543014.89698617 24468584.044221662 1.0 0.7196794385877991 0.8174128325208264 24.835290484268235 -10.877972322713916 10.506167100973105 1.0120898598897752 0.7685461355543128 0.8820467372171175 0.039899490994389664 0.010953601590508236 0.00012722431477791042 0.03745199113665495 0.01287750534528533 1.3244259372514896e-11 10.877972322713916 -0.24354372433546234 LQLLSNLFHGMDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQLLSNLFHGMDK 13 0 Q7L2H7;J3KNJ2;E9PN86 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 0 20682800.0 7843600.0 7252800.0 5586400.0 False True 10153694.8204708 6849175.304276403 4569732.521304508 1.0 0.6745500456117535 0.4500561226334574 23.27550146839015 -8.043754812282405 0.14878176409740715 1.362956825402161 8.322852972903982e-14 0.9999480545392853 0.00162719458580204 0.10011142472570833 0.026069843649303693 0.09853830308110718 0.11632007441134139 9.041597871538767e-09 8.043754812282405 -1.3629568254020776 down LQLLSNLFHGMDK(ub)NTPVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQLLSNLFHGMDKNTPVR 18 1 Q7L2H7;J3KNJ2;E9PN86 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 1 14181900.0 4402800.0 6851400.0 2927700.0 True False 3661123.277111225 6814490.148303575 3539868.5338446526 1.0 1.8613113059881679 0.9668804533229902 21.803854922120603 -6.654748700894556 1.991462436294558 1.5567942124833731 0.9706292146744572 0.21354576869517328 0.367191731415907 0.4970236996525482 3.7834553933110295 0.14925543269738437 0.4068710015839539 2.21437565992686e-07 6.654748700894556 -0.586164997808916 LQLLTWTPLEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQLLTWTPLEAK 12 0 Q9Y5B6-2;Q9Y5B6 Q9Y5B6-2 PAXBP1 PAX3- and PAX7-binding protein 1 0 1985970.0 502510.0 894440.0 589020.0 False True 658795.4763137623 760993.0384998133 528073.8606788067 1.0 1.1551279051852168 0.8015748129200917 19.32947112312265 -6.787434260321318 1.5063495548421608 1.0869950155816401 0.7980661667169863 0.7929209139340043 0.06584608632359984 0.2392279323791925 1.0723751139804376 0.034410013445620224 0.08072296531144661 1.6314198405239612e-07 6.787434260321318 -0.28892884886465386 LQLLTWTPLEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLLTWTPLEAK 12 0 Q9Y5B6-2;Q9Y5B6 Q9Y5B6-2 PAXBP1 PAX3- and PAX7-binding protein 1 0 2993320.0 502510.0 851410.0 1639400.0 False True 688301.5268221379 813791.890963638 1252207.4845028354 1.0 1.1823188809719547 1.8192716937360724 19.392681184645543 -6.9479858657411855 0.5805337348793973 0.9924013701995935 2.0407228714031818 0.999033606072746 0.010918113965903161 0.08430471472874132 0.03938811768410267 0.011432735441790036 0.0532161011035485 1.1272341417897771e-07 6.9479858657411855 1.0483215012035882 LQLMLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQLMLR 6 0 Q15276-2;Q15276 Q15276-2 RABEP1 Rab GTPase-binding effector protein 1 0 15126300.0 4414900.0 4587000.0 6124400.0 False True 5787976.653952413 3902637.479985959 5490705.837393101 1.0 0.6742662787558031 0.9486399420156065 22.464627672034343 -10.061684463195032 6.7953162391420925 1.0000000792990575 0.8114531114500819 0.3863677195863696 0.11201257897412313 1.3460036581863561e-07 1.8550595159941435e-08 0.10845575929228495 0.036151904411043385 8.675919960861236e-11 10.061684463195032 -0.18854696784897562 LQLMLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQLMLR 6 0 Q15276-2;Q15276 Q15276-2 RABEP1 Rab GTPase-binding effector protein 1 0 13956600.0 5263500.0 4110600.0 4582500.0 False True 5096413.07359423 5751984.016495816 3382205.777946776 1.0 1.1286337927155592 0.6636443571402828 22.281050784727313 -6.832940668089878 1.314909023263201 1.0686031437833639 0.6503803992270333 0.9115933861669012 0.05829005774274457 0.1772124477661171 0.598216313110837 0.03479689341092809 0.08007009642604491 1.4691269713186574e-07 6.832940668089878 -0.4182227445563306 LQLMLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLMLR 6 0 Q15276-2;Q15276 Q15276-2 RABEP1 Rab GTPase-binding effector protein 1 0 23313300.0 4414900.0 6928400.0 11970000.0 False True 6047207.838186413 6622280.378845057 9142932.529888323 1.0 1.0950972012285114 1.5119262930163042 22.527837733557234 -6.942779477272129 0.6331829188886605 0.9954512498606871 1.6341597400581862 0.9985057095394825 0.008594232637646339 0.08652128963590303 0.0490058738388774 0.008553817352421868 0.03545977264554002 1.1408289218924226e-07 6.942779477272129 0.6387084901974991 LQLMLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQLMLR 6 0 Q15276-2;Q15276 Q15276-2 RABEP1 Rab GTPase-binding effector protein 1 0 11058400.0 5263500.0 2528800.0 3266100.0 False True 4376833.462586292 2515176.8524725037 3949026.4092598376 1.0 0.5746567407630524 0.9022564927399223 22.06145606016159 -9.794711918104255 6.097996580723737 1.0000000116869503 0.7384566167511468 0.45941380016165 0.13374203870215695 2.1276775735495474e-08 4.113674313370231e-09 0.12949517793366794 0.043165057381595366 1.6043092291915907e-10 9.794711918104255 -0.2615433949358035 LQLNGNLQLELAQVLAQERPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQLNGNLQLELAQVLAQERPK 21 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 530650000.0 134400000.0 217480000.0 178770000.0 False True 203894625.95613444 178668994.82100424 143436031.14232564 1.0 0.8762810396947038 0.7034811754831843 27.60324850988937 -6.966415769683405 0.3328611388746743 1.0203624174689832 0.5537186805379918 0.9999394216314944 0.0009464583159344639 0.07748376701840999 0.013183637966559263 0.0024963636632316065 0.015037734969020333 1.0803991412447771e-07 6.966415769683405 -0.46664373693099137 LQLNGNLQLELAQVLAQERPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQLNGNLQLELAQVLAQERPK 21 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 13534300.0 8503400.0 1355500.0 3675400.0 False True 7070953.864492502 1348197.6524543162 4443909.146870461 1.0 0.19066701300717356 0.6284737861444681 22.753473415582214 -10.040424495674667 6.050069007554281 1.0000009239960237 0.4095703996183449 0.7080283809093348 0.1787338666869098 2.2273125115875376e-06 3.5335249412551135e-07 0.1730585930120215 0.05768610742345557 9.111198413592162e-11 10.040424495674667 -0.5904305243776788 LQLNGNLQLELAQVLAQERPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQLNGNLQLELAQVLAQERPK 21 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 270907000.0 134400000.0 60928000.0 75579000.0 False True 173983449.4200718 57537303.23998353 61824397.506027825 1.0 0.33070561269919085 0.35534642928452814 27.374374831981818 -10.321537589516389 5.714121459106617 1.0000872431925651 0.3430260209918855 0.9989460565769366 0.0100595712466121 1.1181984668896698e-05 1.3276848317157584e-06 0.009741418510982968 0.0032467126590075166 4.7693853184328786e-11 10.321537589516389 -0.6570612222006796 LQLNYLGNYIPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQLNYLGNYIPR 12 0 Q02809;Q02809-2 Q02809 PLOD1 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 0 10994800.0 2371700.0 5295600.0 3327500.0 False True 3109321.6675754683 4505517.122087128 2983202.219633848 1.0 1.4490353857792915 0.9594382757960312 21.568168444353287 -6.665541030663211 1.9535922791982099 1.2877157405346518 0.9614685548931311 0.2592896472820255 0.19093988631869727 0.4714278702501522 3.464399305004857 0.07881380743917328 0.21177097538957135 2.1600259532405727e-07 6.665541030663211 -0.32624718564152067 LQLNYLGNYIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLNYLGNYIPR 12 0 Q02809;Q02809-2 Q02809 PLOD1 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 0 17025600.0 2371700.0 5108800.0 9545100.0 False True 3248581.5827825572 4883076.323457591 7290743.96750518 1.0 1.503141047569141 2.2442853232149176 21.631378505876178 -6.965556925229336 0.34836145680974456 0.9270134868397928 2.8453589888220363 0.9999241700073507 0.004450376209021726 0.07777247584536337 0.014196392320403574 0.010216536029913193 0.06377323330120278 1.082537811984095e-07 6.965556925229336 1.9183455019822435 LQLPVWEYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQLPVWEYK 9 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 5493000.0 1089400.0 1781600.0 2622000.0 False True 1428213.9497646063 1515792.2246224058 2350700.591999985 1.0 1.0613201368550096 1.6459022770274858 20.44578068394604 -6.926986259208331 0.7711163977883198 0.9900473746175028 1.757199650859047 0.9959124321337662 0.018611619012724536 0.0942324332530592 0.08556569420032115 0.01666165630938071 0.053797376989620935 1.1830789869737689e-07 6.926986259208331 0.7671522762415443 LQLPVWEYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQLPVWEYK 9 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 2863290.0 983410.0 710780.0 1169100.0 False True 952192.1878414187 994598.1606687325 862877.6377517906 1.0 1.0445350984483988 0.9062011312106009 19.860893266943037 -6.8200612591902505 1.3716541350894482 1.0240023488011427 0.9031781915560925 0.8845189418849009 0.019592938762937013 0.1933987972536782 0.714969967289401 0.011224986701704756 0.02587079194729544 1.513347768870175e-07 6.8200612591902505 -0.12082415724505025 LQLPVWEYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLPVWEYK 9 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 6995900.0 1089400.0 2106000.0 3800500.0 False True 1492180.6199280347 2012949.956389308 2902900.1737544388 1.0 1.348998860799029 1.9454080390713295 20.50899074546893 -6.963000088153561 0.39085926902997953 0.96371958341601 2.352146438449178 0.9998658001021277 0.004521898365897076 0.07864632313258378 0.017294878057986504 0.007696717576998054 0.05015066166095209 1.0889298723012545e-07 6.963000088153561 1.3884268550331682 LQLQSIEEGDVLAAEQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQLQSIEEGDVLAAEQR 17 0 A0A0A0MQW8;Q8N6U8-3;Q8N6U8-5;Q8N6U8-4;Q8N6U8;Q8N6U8-6 A0A0A0MQW8 GPR161 G-protein coupled receptor 161 0 24307200.0 3382000.0 6918200.0 14007000.0 False True 5130741.257318801 5683593.15785669 11238510.310513817 1.0 1.1077528319615157 2.1904262458143884 22.290735841745867 -6.926116863251256 0.7779950744242575 0.9809530102270316 2.392209822140449 0.9957188094776029 0.035174135499232595 0.09470418156265276 0.08792597899369156 0.03133415507106104 0.10013561983167242 1.1854497154497635e-07 6.926116863251256 1.4112568119134172 up LQLQSIEEGDVLAAEQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQLQSIEEGDVLAAEQR 17 0 A0A0A0MQW8;Q8N6U8-3;Q8N6U8-5;Q8N6U8-4;Q8N6U8;Q8N6U8-6 A0A0A0MQW8 GPR161 G-protein coupled receptor 161 0 11877400.0 3382000.0 2919500.0 5575900.0 False True 4378065.66918663 2757027.258553246 4561143.413565411 1.0 0.6297363874547488 1.0418170393530881 22.061862163838317 -6.670031276592416 1.9386348867281034 0.7636513635531973 1.0401022420566834 0.27868223909848955 0.1572817032971869 0.4609914893738649 3.3406313991834304 0.06533497832287148 0.1744643091659807 2.137808125397469e-07 6.670031276592416 0.27645087850348615 LQLSLADFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQLSLADFR 9 0 B5MCF9;O00541-2;O00541 B5MCF9 PES1 Pescadillo homolog 0 14884900.0 5444600.0 5618700.0 3821600.0 False True 7137923.325581411 4780411.8615210615 3426177.491375726 1.0 0.669720259446984 0.4799963988260761 22.76707297359741 -10.35006360483358 0.10437300926550824 1.8550110238498656 3.622646490646118e-16 0.9999055086057219 0.002088575385569155 2.133024934008614 0.05382074425777711 0.7420991965107252 0.2764081262677612 4.466181776538068e-11 10.35006360483358 -1.8550110238498652 LQLSLADFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQLSLADFR 9 0 B5MCF9;O00541-2;O00541 B5MCF9 PES1 Pescadillo homolog 0 9284200.0 4870600.0 2209500.0 2204100.0 False True 4715985.469031644 3091764.8723902823 1626780.0884173475 1.0 0.6555925357897953 0.34495019102579677 22.169127842394122 -7.419368302005126 0.24670531443263727 1.1304135677862823 1.1717225737237937e-14 0.9999068931306895 0.0025815509954093133 0.1202220927574006 0.020748524929239374 0.02218065498771346 0.058271431836400746 3.8074279876654424e-08 7.419368302005126 -1.1304135677862706 down LQLSLADFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLSLADFR 9 0 B5MCF9;O00541-2;O00541 B5MCF9 PES1 Pescadillo homolog 0 22071400.0 5444600.0 5902800.0 10724000.0 False True 7457615.754782624 5641994.778050718 8191212.067712819 1.0 0.7565413616855313 1.0983687463999114 22.830283035120303 -6.715446196036178 1.7755675546388998 0.851166427239256 1.0977088613738004 0.4909731934152235 0.1025098209797158 0.36425818266419907 2.2416934283855214 0.04588508563426094 0.11581609209160985 1.925545582687341e-07 6.715446196036178 0.24654243413454446 LQLSLADFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQLSLADFR 9 0 B5MCF9;O00541-2;O00541 B5MCF9 PES1 Pescadillo homolog 0 9698400.0 4870600.0 2040000.0 2787800.0 False True 4050119.70416506 2029010.1150917024 3370716.0906691714 1.0 0.5009753447546526 0.832250979447051 21.9495331178284 -10.133734353136362 5.47650351792556 1.0000060095424075 0.6666131621007743 0.5745372487063357 0.13524271153578368 9.923572142550462e-06 1.5697377505329569e-06 0.13095055072591527 0.043649397456127954 7.349632890018215e-11 10.133734353136362 -0.3333928474416332 LQLSLYMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQLSLYMK 8 0 Q8WTV0-4;Q8WTV0-2;B7ZKQ9;Q8WTV0-3;Q8WTV0-5;Q8WTV0;F5H4X0 Q8WTV0-4 SCARB1 Scavenger receptor class B member 1 0 6597600.0 4320200.0 1215200.0 1062200.0 False True 4183057.6157579217 1700435.6971842826 783977.9546830481 1.0 0.40650544491154067 0.18741744118697737 21.99612643854585 -11.309097659373222 0.18680836526953018 2.141499849837087 8.397720320667017e-11 0.999438650531604 0.008133096096680423 3.7253978434464043 0.1102308701701151 1.9097611408305044 0.1497402678183801 4.907974985917805e-12 11.309097659373222 -2.1414998497531097 LQLSLYMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQLSLYMK 8 0 Q8WTV0-4;Q8WTV0-2;B7ZKQ9;Q8WTV0-3;Q8WTV0-5;Q8WTV0;F5H4X0 Q8WTV0-4 SCARB1 Scavenger receptor class B member 1 0 37900700.0 9534700.0 10624000.0 17742000.0 False True 14464836.97994013 8728064.194309136 14235285.923405139 1.0 0.6033987252267852 0.9841304083237624 23.7860467282632 -10.684069944520706 9.641691954111895 1.0001854654458422 0.7937645674329897 0.2812093164156715 0.1554330587497702 0.0006202185654385388 2.032276991969169e-05 0.15063020355748347 0.05016580399899491 2.0698079727265498e-11 10.684069944520706 -0.20642089801285246 LQLSLYMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQLSLYMK 8 0 Q8WTV0-4;Q8WTV0-2;B7ZKQ9;Q8WTV0-3;Q8WTV0-5;Q8WTV0;F5H4X0 Q8WTV0-4 SCARB1 Scavenger receptor class B member 1 0 29023200.0 9534700.0 9509600.0 9978900.0 False True 12342857.107035397 8980382.400389763 8162842.59216052 1.0 0.7275772799209486 0.6613414156360703 23.55717305035565 -13.999999999999998 0.19862546043910473 2.506513660359658 0.6177375216453629 0.9994869227741661 0.0033195195803951308 12.504050566270887 0.14132120287132452 7.314172494594706 0.04261187255507882 1.0000000000000041e-14 13.999999999999998 -1.8887761387142952 LQLSVYTTTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQLSVYTTTR 10 0 Q96KA5;Q96KA5-2 Q96KA5 CLPTM1L Cleft lip and palate transmembrane protein 1-like protein 0 4134700.0 0.0 2331000.0 1803700.0 False True 0.0 1983223.8861668326 1617070.4263121183 0.0 LQLSVYTTTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLSVYTTTR 10 0 Q96KA5;Q96KA5-2 Q96KA5 CLPTM1L Cleft lip and palate transmembrane protein 1-like protein 0 4142700.0 0.0 2087700.0 2055000.0 False True 0.0 1995458.5108993144 1569651.3240535124 0.0 LQLTLYQYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQLTLYQYK 9 0 Q9H7Z7 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 0 20429700.0 6371200.0 9239200.0 4819300.0 False True 8352704.898788566 7860747.374119531 4320645.065989909 1.0 0.9411020105905591 0.5172749568366235 22.9938120378261 -6.932122974153268 0.729163811469557 1.005964882811096 0.425369420898138 0.996939093938676 0.011896355545370932 0.09155076673587137 0.07239149132346097 0.010978289247755905 0.0379114183936472 1.1691682842625838e-07 6.932122974153268 -0.5805954619129581 LQLTLYQYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQLTLYQYK 9 0 Q9H7Z7 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 0 137714000.0 31470000.0 32145000.0 74099000.0 False True 47742290.765175276 26408473.59996869 59453300.171254575 1.0 0.5531463441890782 1.2452963445696594 25.50876445552167 -6.732390489400643 1.7143469613086268 0.7318042894693424 1.2450796985976225 0.5703619535953564 0.1878143859356916 0.3317872174148602 1.9113750453659797 0.08677635397258247 0.2147630679721738 1.8518657971371254e-07 6.732390489400643 0.5132754091282801 LQLTLYQYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLTLYQYK 9 0 Q9H7Z7 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 0 39462200.0 6371200.0 13617000.0 19474000.0 False True 8726804.815206075 13015355.914602665 14874642.279619511 1.0 1.491422827736903 1.704477479970802 23.05702209934899 -11.105414792061069 0.15763281753530356 1.3850812855165956e-20 1.9641597767948182 0.9995988950183651 0.005907960511431036 3.3987827581088945 0.09294854190424465 1.4053081539774406 0.18732998385669242 7.844860187876826e-12 11.105414792061069 1.9641597767948182 LQLTLYQYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQLTLYQYK 9 0 Q9H7Z7 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 0 23901800.0 9282700.0 6637400.0 7981700.0 False True 7718976.343336145 6601643.008779254 9650636.566788921 1.0 0.8552485090174561 1.250248237270528 22.87997810563707 -6.807550656641902 1.425068300045122 0.9208804664001309 1.256760716387438 0.8532617973107156 0.06250223167035306 0.2101658808087897 0.8416926707140767 0.03449317683973383 0.07987229667378698 1.5575763466170818e-07 6.807550656641902 0.33588024998730703 LQLTLYQYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQLTLYQYK 9 0 Q9H7Z7 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 0 127564000.0 31470000.0 50943000.0 45151000.0 False True 40738535.36644097 48107977.26750403 36933981.28838249 1.0 1.1808960934597998 0.9066104354553567 25.27989077761412 -6.728861002233182 1.7276063132918933 1.1090027853952298 0.9068144149931737 0.5538603353611253 0.07605153104333516 0.33838655802723727 1.978115611450619 0.03489432547076161 0.08669239154831782 1.8669771290682827e-07 6.728861002233182 -0.20218837040205606 LQLVLAPLHSLASQALEHGLPDPGSLLVHSFQQLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQLVLAPLHSLASQALEHGLPDPGSLLVHSFQQLGR 36 0 Q9UHF1 Q9UHF1 EGFL7 Epidermal growth factor-like protein 7 0 819840000.0 419450000.0 150990000.0 249400000.0 False True 542986293.5956037 142587273.76912305 204011759.06010032 1.0 0.2625982929051922 0.37572174742967046 29.016340540164954 -10.143501825149007 5.551320804996096 1.0000119770135483 0.31916002016733186 0.979714943569672 0.04618245692133532 6.8458578462787456e-06 1.0562930144207988e-06 0.04471675749164794 0.014905323878555204 7.186181383376238e-11 10.143501825149007 -0.6808519568462164 LQLVMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQLVMK 6 0 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 0 94656000.0 30485000.0 27169000.0 37002000.0 False True 39966130.21715992 23115491.103932556 33173387.988246918 1.0 0.5783770151959234 0.8300375294779864 25.25227455253679 -10.279902271192778 5.7591331652747035 1.0000210789406017 0.7042072723369526 0.6481319309267137 0.10273997473291771 2.7808458611818662e-05 3.477033260634757e-06 0.09948463377870322 0.03315918426086212 5.2492557038106214e-11 10.279902271192778 -0.2958138066036491 LQLVMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQLVMK 6 0 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 0 53717800.0 20021000.0 9049800.0 24647000.0 False True 19385444.31394132 12663432.334083537 18191211.305849254 1.0 0.6532443687646844 0.9383953759969683 24.208470466216994 -9.980407576774025 6.571673110653692 1.0000000406991518 0.7958198723808241 0.4060423528422965 0.11641241122663662 6.941940472919342e-08 1.0862209842820426e-08 0.11271585516766629 0.03757194416438321 1.0461462996198297e-10 9.980407576774025 -0.20418016831832775 LQLVMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLVMK 6 0 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 0 93841000.0 30485000.0 28216000.0 35140000.0 False True 41756128.32614845 26969323.82216559 26840655.73101722 1.0 0.6458770222065082 0.6427956040696693 25.31548461405968 LQLVMK(ub)SGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LQLVMKSGK 9 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 117642090.0 49287200.0 62226400.0 6128490.0 True False 64615996.497923754 52942463.67660741 5494372.643427156 1.0 0.8193398933081308 0.08503115236493647 25.94538803054495 -7.135104660482676 0.7407032412992706 0.997780016402217 2.4458554216955153e-25 0.9963176458219848 0.024010399185856304 0.0815265006787724 0.07724017338408445 0.02194358017404184 0.055625746689624986 7.326479512765782e-08 7.135104660482676 -0.997780016402217 down LQLVMK(ub)SGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LQLVMKSGK 9 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 171269480.0 93172000.0 70430000.0 7667480.0 True False 90214305.85977428 98553066.28759807 5659136.968530572 1.0 1.092432794869422 0.06272992863600726 26.4268528932181 -6.901683512705127 1.0777111157489465 1.060602475956182 2.6721826339628044e-17 0.9774326127558151 0.0698773774240776 0.11741175377322272 0.2520547740626544 0.0506379028027679 0.11723972717347556 1.2540547205246802e-07 6.901683512705127 -1.060602475956182 down LQLVMK(ub)SGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQLVMKSGK 9 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 184160500.0 133040000.0 44742000.0 6378500.0 True False 201831406.52681628 36757440.52915841 5117786.679204138 1.0 0.18211952818291757 0.025356740892177078 27.588575445510514 -10.70641820335549 0.33896697544876064 1.7950074781265877 2.4300262055442884e-15 0.9990905009462124 0.012887116832726706 2.480320968742051 0.176040718108004 1.6712506096821358 0.048723805440004105 1.965992228030224e-11 10.70641820335549 -1.7950074781265852 LQLVMK(ub)SGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQLVMKSGK 9 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 94531500.0 40013000.0 48705000.0 5813500.0 True False 54806887.41066682 46553052.05410315 4440471.032790796 1.0 0.8494014941093468 0.08102031044964189 25.70785386777776 -7.095663060489809 0.7815153236949275 0.9993528994765776 1.6088471130237415e-21 0.9961052254469993 0.02511545471737846 0.07900815360892413 0.08277954133990695 0.02284280509319028 0.05624096681677053 8.02300272130984e-08 7.095663060489809 -0.9993528994765776 down LQLVMK(ub)SGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LQLVMKSGK 9 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 250307440.0 93172000.0 154996000.0 2139440.0 True False 77476646.21945287 154161005.7837029 2586787.0123471045 1.0 1.9897738648500778 0.03338795803086289 26.207258168652377 -6.7691818525371374 1.577806897939286 1.568300041244628 0.022778055259726593 0.7273581286115576 0.4170473083891335 0.2677457160628512 1.3153651174743473 0.2083698510271694 0.49633521449938683 1.7014459111644344e-07 6.7691818525371374 -1.5455219859849014 LQLVMK(ub)SGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQLVMKSGK 9 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 179971500.0 133040000.0 42818000.0 4113500.0 True False 172222902.61046386 40435140.659953006 3364885.2080742684 1.0 0.23478376015650929 0.019537965956159805 27.359701767602964 -9.513045935164099 0.39839028071211424 1.2552384805658792 4.1347492079178353e-16 0.9979852844161194 0.018885118625121135 0.9174802620266979 0.17694528432479978 0.38331830266185424 0.054903926402359346 3.0686973962553914e-10 9.513045935164099 -1.2552384805658787 LQLYQLFHYLNHWNHFGSGYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQLYQLFHYLNHWNHFGSGYR 21 0 Q9HA64;I3L378 Q9HA64 FN3KRP Ketosamine-3-kinase 0 21158700.0 9276900.0 5355700.0 6526100.0 False True 12009129.925037676 5057650.586961327 5338416.763440746 1.0 0.4211504595696561 0.44452985326695077 23.517628294163952 -10.17001672810723 5.332706452985646 1.0000212641645416 0.4328401564181536 0.9987271892457593 0.00954459750962244 2.4130825911529228e-06 3.7555397818815887e-07 0.009241862637683262 0.0030805055999954542 6.76056934603595e-11 10.17001672810723 -0.567181107746388 LQMEAPHIIVGTPGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 LQMEAPHIIVGTPGR 15 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 223085300.0 56700800.0 89789400.0 76595100.0 False True 74335297.89132829 76393171.51633991 68669773.8040801 1.0 1.0276836668902578 0.9237842014767911 26.1475440970519 -6.835843453157934 1.3017466656606138 1.0147432882268628 0.9206425836237938 0.9170325345616819 0.012654257812962307 0.17371439263586486 0.5736261764692905 0.0076277188421504565 0.017556244178914382 1.4593402027866427e-07 6.835843453157934 -0.09410070460306896 LQMEAPHIIVGTPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQMEAPHIIVGTPGR 15 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 51746200.0 18502000.0 13332000.0 19912200.0 False True 17914664.137482747 18655537.125461537 14696597.46680452 1.0 1.041355672776955 0.8203668990955244 24.09463766049643 -6.858329118473493 1.1941394262642298 1.0223464547973138 0.8100018270883081 0.9515735245767476 0.0211092614914029 0.1485385974372278 0.40343466653196536 0.013796348965732948 0.032146849118851184 1.385705311109677e-07 6.858329118473493 -0.21234462770900564 LQMEAPHIIVGTPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQMEAPHIIVGTPGR 15 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 213567000.0 25210000.0 140970000.0 47387000.0 False True 38245413.09787311 115812802.0963628 38020938.67954004 1.0 3.028148808328687 0.9941306839134246 25.188783395081785 -6.646819728083036 2.019797763729644 2.3193391931769796 1.002642446486457 0.1813434737280879 0.8663108189875227 0.5163289904104097 4.033739285612407 0.34828225618291775 0.959488371725637 2.2551751217581913e-07 6.646819728083036 -1.3166967466905226 LQMEAPHIIVGTPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQMEAPHIIVGTPGR 15 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 194915000.0 50065000.0 58040000.0 86810000.0 False True 68575383.45575272 55475600.887386285 66307265.90807071 1.0 0.8089725217968503 0.966925193365554 26.031187448484012 -10.048299957502685 5.642973572491118 1.0000004775271847 0.8879488576081784 0.4015530986484259 0.06448390814224973 3.8735394888524584e-07 6.54550699606722e-08 0.062436541668548666 0.020812091861090124 8.947465706070479e-11 10.048299957502685 -0.11205161991900625 LQMEAPHIIVGTPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQMEAPHIIVGTPGR 15 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 118606000.0 25210000.0 62854000.0 30542000.0 False True 32634841.963392917 59356119.646893494 24983669.387384057 1.0 1.8187959884553542 0.7655520261262084 24.959909717174234 -6.699244845111126 1.8338322630597028 1.5088279384299412 0.7687586689830831 0.4138537429927902 0.34567352329250595 0.3971048206575114 2.5958240379242143 0.1504189846249852 0.38716020298775594 1.9987347118639843e-07 6.699244845111126 -0.7400692694468581 LQMK(ub)EMTCR ddPTM_RPMI8226_Bortezomib_1h_R1 3 LQMKEMTCR 9 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 13844930.0 4668770.0 4810860.0 4365300.0 True False 6120802.682432994 4093098.4405854037 3913620.6309143947 1.0 0.6687192273544119 0.6393966337367285 22.545289429763404 -13.999999999999996 0.34323408607398515 4.908089041220212 0.6349750653328278 0.9997416082356009 0.0026284658693447103 20.004855353042057 0.18813864403696626 56.81567338353821 0.0089565156838407 1.0000000000000082e-14 13.999999999999996 -4.273113975887384 LQMK(ub)EMTCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQMKEMTCR 9 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 8746100.0 3567500.0 2115700.0 3062900.0 True False 3454251.665250772 2960510.0432297476 2260634.604969597 1.0 0.8570626376219233 0.654449884966757 21.719941765967118 -6.966180542047297 0.33718061286647755 1.0227065363940244 0.48210129395962276 0.9999354481853886 0.0011390221023907313 0.07756262714697497 0.013460029314993382 0.0028855013577197214 0.01757373875265654 1.0809844781167148e-07 6.966180542047297 -0.5406052424344017 LQMK(ub)EMTCR ddPTM_RPMI8226_Bortezomib_8h_R1 2 LQMKEMTCR 9 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 83520000.0 13307000.0 19842000.0 50371000.0 True False 20187691.872011036 16301040.073746411 40415149.77160644 1.0 0.8074741866031142 2.0019698154616425 24.26697263604204 -6.865605173526484 1.1571545920038429 0.8935405205447018 2.066304178268812 0.9600931826253294 0.10460678816454509 0.14113486823319704 0.35598278070804407 0.07033146871197908 0.1653480308893778 1.362682963957867e-07 6.865605173526484 1.17276365772411 up LQMK(ub)EMTCR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LQMKEMTCR 9 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 11760630.0 4264650.0 3571120.0 3924860.0 True False 5841406.35283284 3413336.1102853664 2997888.9030290297 1.0 0.5843346454796866 0.5132135520027943 22.47788431753883 -13.999999999999998 0.2483834530180646 3.867373430766744 0.48417390728314846 0.9995396767821592 0.004606039074671079 13.93447915964294 0.15770774411332153 19.916113072534515 0.03311958099490909 1.0000000000000041e-14 13.999999999999998 -3.3831995234835954 LQMK(ub)EMTCR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LQMKEMTCR 9 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 13755120.0 4617400.0 4119310.0 5018410.0 True False 3839572.6855031755 4097118.4594109883 6067736.328493829 1.0 1.067076676235408 1.5803155261009605 21.872514328497388 -6.930933844009614 0.7390813096518684 0.9924597153802961 1.6882330447723781 0.9967187634320466 0.014847731635057627 0.09215548807570924 0.0753242584455974 0.013603008787825069 0.04620294998409248 1.1723739394312483e-07 6.930933844009614 0.695773329392082 LQMK(ub)EMTCR ddPTM_RPMI8226_Carfilzomib_8h_R1 3 LQMKEMTCR 9 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 59354100.0 14366900.0 15393900.0 29593300.0 True False 18598235.2639377 14537215.932674335 24207623.052900046 1.0 0.7816449101954446 1.301608604760423 24.148662398622687 -6.792599969814964 1.4857161447455451 0.8783759954207496 1.3075599609573054 0.8097277179896367 0.09298928493502957 0.23148060066863074 1.0093045159053189 0.049255795915142564 0.11511598251517828 1.6121298900470912e-07 6.792599969814964 0.4291839655365558 LQNCK(ub)EDEQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQNCKEDEQR 10 1 Q96SU4-3;Q96SU4-7;Q96SU4-2;Q96SU4;Q96SU4-6;E9PK98;H0YE19 Q96SU4-3 OSBPL9 Oxysterol-binding protein-related protein 9 1 3010330.0 1553000.0 1002100.0 455230.0 True False 2127186.0682469583 957823.9084984442 347714.04975614575 1.0 0.4502774453049137 0.16346198151001498 21.02051480290315 -8.88729665220463 0.27146769937200704 1.266103283510819 4.202491102075657e-21 0.9989710990714297 0.011133480524380065 0.38535879057059236 0.08833043811461595 0.20538374300383558 0.10520714869392024 1.2962935132536153e-09 8.88729665220463 -1.266103283510819 LQNIIDNQK(ub)YSVADIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQNIIDNQKYSVADIER 17 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 15236600.0 3238300.0 3722900.0 8275400.0 True False 3135501.939055803 5209473.384667019 6107824.483321495 1.0 1.6614479869324377 1.947957488797073 21.58026498109856 -10.47434561008443 0.17895933068726239 5.5439006225711713e-17 2.245011336537753 0.9995147169644819 0.008744776265246596 2.230560399428695 0.09211523226051854 1.1953284971232583 0.20506758127108993 3.3547054166333745e-11 10.47434561008443 2.245011336537753 LQNIIDNQK(ub)YSVADIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQNIIDNQKYSVADIER 17 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 47144000.0 0.0 13195000.0 33949000.0 True False 0.0 10840249.156994434 27238965.269624684 0.0 LQNIIDNQK(ub)YSVADIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQNIIDNQKYSVADIER 17 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 44076400.0 0.0 9354300.0 34722100.0 True False 0.0 8833724.981909443 28403034.07883203 0.0 LQNK(ub)EHVIEALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQNKEHVIEALR 12 1 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 6477380.0 1165200.0 959280.0 4352900.0 True False 1527588.4838128528 816159.163244154 3902503.663965196 1.0 0.5342794685169562 2.554682563608078 20.542824518245947 -6.84603680496965 1.2539386897417582 0.7520608048244739 2.6295336245396097 0.9343498115784923 0.22133538667242092 0.1618758813241977 0.4917763665211191 0.13824393740480576 0.31922163348909327 1.4254867833613e-07 6.84603680496965 1.8774728197151358 up LQNLEFALNLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQNLEFALNLLR 12 0 O60437;K7EKI8;K7EQ71 O60437 PPL Periplakin 0 35758700.0 8147700.0 13896000.0 13715000.0 False True 12360656.576657725 11416150.230056455 11004224.238501957 1.0 0.9235876880209659 0.8902621127167871 23.55925204294976 -13.999999999988278 0.11287198419668809 1.3670141776918092 0.8315797275051535 0.9997284922614129 0.0007569038850265372 11.996571100187317 0.10240684179869894 0.9982778393942877 0.0520916577283595 1.0000000000269913e-14 13.999999999988278 -0.5354344501866557 LQNLEFALNLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQNLEFALNLLR 12 0 O60437;K7EKI8;K7EQ71 O60437 PPL Periplakin 0 25124300.0 8147700.0 9977500.0 6999100.0 False True 10547358.265177982 9422243.354072604 5725335.616830593 1.0 0.8933273258745809 0.5428217637901561 23.330378365042208 -6.949388920410992 0.5655121629994067 1.0044586644858708 0.41477991782233214 0.9991524543107659 0.005685416489139602 0.08373204356383178 0.03698500356239099 0.006054650195799246 0.029172682884697626 1.1235983158979348e-07 6.949388920410992 -0.5896787466635387 LQNLQLQPGNAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQNLQLQPGNAK 12 0 P22307-7;P22307-8;P22307;P22307-6;P22307-2;P22307-4 P22307-7 SCP2 Non-specific lipid-transfer protein 0 5036220.0 1341300.0 598020.0 3096900.0 False True 1298721.1656905 836812.5046331016 2285728.984991463 1.0 0.6443357717883867 1.7599843949383804 20.308660287980427 -6.820975709771981 1.3679158168178898 0.8084922125541711 1.784799489252831 0.8865536655655317 0.15672977327741855 0.1922196597010865 0.7065270015459698 0.0900361734620552 0.20743935997186172 1.5101646157877379e-07 6.820975709771981 0.9763072766986598 LQNQLQGAIVIERPNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQNQLQGAIVIERPNVK 17 1 O75351 O75351 VPS4B Vacuolar protein sorting-associated protein 4B 0 8748400.0 1832800.0 4049200.0 2866400.0 False True 2402818.5488604484 3445075.14365798 2569812.424450329 1.0 1.4337641705370672 1.0694991620025067 21.196296275410273 -10.24848798001736 6.061314887648635 0.9999929916739577 1.2516316662697877 0.3888500690755198 0.14871056701004123 1.4084239447066217e-05 1.7462886713173949e-06 0.14399239619334367 0.047996129119578956 5.643025593494416e-11 10.24848798001736 0.25163867459583 LQNQLQGAIVIERPNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQNQLQGAIVIERPNVK 17 1 O75351 O75351 VPS4B Vacuolar protein sorting-associated protein 4B 0 8350600.0 2227300.0 1532500.0 4590800.0 False True 2156595.5806623823 2144435.241881923 3388331.758952116 1.0 0.9943613263008151 1.571148429188293 21.040324227289396 -6.904694361552867 0.9311297888460797 0.9790087488296645 1.6378071425721126 0.9887599730041211 0.028686702667702266 0.10803176472583594 0.15858044002490687 0.02288664352752393 0.061078474367710404 1.2453907578093487e-07 6.904694361552867 0.6587983937424481 LQNQLQGAIVIERPNVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQNQLQGAIVIERPNVK 17 1 O75351 O75351 VPS4B Vacuolar protein sorting-associated protein 4B 0 36371000.0 5475000.0 23018000.0 7878000.0 False True 8305975.276114856 18910258.059545137 6320909.846949935 1.0 2.276705315259554 0.7610075441864979 22.985718146711783 -6.683356188286958 1.889821126533722 1.8053311798664604 0.7665956952432305 0.33961821690500293 0.5407040018086274 0.4311068318054284 2.979566424650174 0.2293323086077441 0.6022917141769456 2.073212466823169e-07 6.683356188286958 -1.03873548462323 LQNQLQGAIVIERPNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQNQLQGAIVIERPNVK 17 1 O75351 O75351 VPS4B Vacuolar protein sorting-associated protein 4B 0 7692500.0 1832800.0 2884100.0 2975600.0 False True 2510435.6895576497 2756670.925556699 2272824.5644056597 1.0 1.0980846619665596 0.9053506424640345 21.259506336933164 -6.768343389302386 1.5806238511651225 1.0563774229023988 0.9043294899342992 0.7242436646391881 0.04132077843038399 0.26911813717834865 1.3266392830844516 0.02060820842409577 0.04913444045319821 1.7047339516736434e-07 6.768343389302386 -0.1520479329680996 LQNQLQGAIVIERPNVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQNQLQGAIVIERPNVK 17 1 O75351 O75351 VPS4B Vacuolar protein sorting-associated protein 4B 0 5742400.0 2227300.0 1957500.0 1557600.0 False True 1852098.6361201606 1946954.5589666713 1883286.9584713052 1.0 1.0512153731969796 1.0168394499854927 20.820729502723673 -10.458039633748111 4.485421370538077 0.999873843885241 1.0340274115912749 0.5664304116988375 0.01403391188433807 1.7770459862007256e-05 2.1471448582536157e-06 0.013638641814060085 0.0045294255841635276 3.483055271961199e-11 10.458039633748111 0.03415356770603384 LQNQLQGAIVIERPNVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQNQLQGAIVIERPNVK 17 1 O75351 O75351 VPS4B Vacuolar protein sorting-associated protein 4B 0 20744400.0 5475000.0 10022000.0 5247400.0 False True 7087495.428384626 9464266.889953973 4292427.042870769 1.0 1.3353471597386353 0.6056338358512485 22.756844468804232 -6.781749404649346 1.5290658769487582 1.1894496163214598 0.5995340217974333 0.7735323092558722 0.14192299013775006 0.24786333940515337 1.1447569350152318 0.07309647447685254 0.17222567436935293 1.652915283528396e-07 6.781749404649346 -0.5899155945240265 LQNVQIALDFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQNVQIALDFLK 12 0 H3BQK9;Q9UPN3-4;Q9UPN3-2;Q9UPN3;A0A590UJG2;H3BPE1;Q9UPN3-3;E9PLY5;A0A5F9ZGX0;E9PS75 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 0 2320780.0 1434200.0 0.0 886580.0 False True 1192600.8458328603 0.0 1071959.7789172367 1.0 0.0 0.8988420414615981 20.18567983440738 -9.146407002115373 12.153452754849905 1.0000000002980345 0.4494210376653623 0.33345677861622014 0.366950726823749 0.0 0.0 0.35529851346677094 0.11843283782225696 7.138270444993741e-10 9.146407002115373 -0.5505789626326723 LQNVQIALDFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQNVQIALDFLK 12 0 H3BQK9;Q9UPN3-4;Q9UPN3-2;Q9UPN3;A0A590UJG2;H3BPE1;Q9UPN3-3;E9PLY5;A0A5F9ZGX0;E9PS75 H3BQK9 MACF1 Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 0 6113800.0 2824000.0 3289800.0 0.0 False True 3655723.66936222 3106719.738033386 0.0 1.0 0.8498234601455493 0.0 21.801725592699512 -7.178484202822187 0.9112492550737694 0.9919576896999992 4.524365540731339e-19 0.9895297145183204 0.04505313003008224 0.09054989814156152 0.14257745058643564 0.03785564913746339 0.06644419910341383 6.630034635495437e-08 7.178484202822187 -0.9919576896999992 down LQNVQIALDYLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQNVQIALDYLR 12 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1;E9PMV1;E9PQ28;E9PIA2;E9PKG0 Q15149 PLEC Plectin 0 4348740.0 999140.0 2478400.0 871200.0 False True 1309882.2156855224 2108632.3807275356 781056.5811404993 1.0 1.6097877774636324 0.5962800103608827 20.32100566010518 -6.74378970537763 1.6727415331354938 1.3612265028928692 0.5951762802935184 0.6218152309662629 0.25619774488354424 0.3110285342764724 1.7101582896547234 0.1210936208527313 0.2959349755964496 1.8038910117976655e-07 6.74378970537763 -0.7660502225993507 LQNVQIALDYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQNVQIALDYLR 12 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1;E9PMV1;E9PQ28;E9PIA2;E9PKG0 Q15149 PLEC Plectin 0 12696700.0 3092400.0 4758600.0 4845700.0 False True 4691396.8847228475 3909390.6508884993 3887945.271054241 1.0 0.8333105782670215 0.8287393641145601 22.1615861250293 LQNVQIALDYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQNVQIALDYLR 12 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1;E9PMV1;E9PQ28;E9PIA2;E9PKG0 Q15149 PLEC Plectin 0 6401940.0 999140.0 1317800.0 4085000.0 False True 1368549.0587432494 1259575.2386181543 3120207.133215857 1.0 0.9203727338608039 2.27993809449635 20.38421572162807 -6.89299805891079 1.0044580355432011 0.932112448404103 2.4039892474483566 0.9827495623188559 0.08182350821895241 0.11674512531732939 0.2078985574182001 0.06181030401573784 0.1558570220151975 1.2793870223945682e-07 6.89299805891079 1.4718767990442536 up LQPHEFQGGTFTISNLGMFGIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQPHEFQGGTFTISNLGMFGIK 22 0 P10515;H0YDD4;E9PEJ4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 29879200.0 14789000.0 4480200.0 10610000.0 False True 14319531.290089313 6269167.223934361 7830922.70682275 1.0 0.4378053371253368 0.546870044010631 23.77148093498895 -9.970066962231197 6.090795880542014 1.0000002706842648 0.4923376905681807 0.9665419512084482 0.044525480136071265 33260120.397060383 54443726.01602334 91.41620725194157 0.015242256974329668 1.0713541044460006e-10 9.970066962231197 -0.5076625801160841 LQPHEFQGGTFTISNLGMFGIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQPHEFQGGTFTISNLGMFGIK 22 0 P10515;H0YDD4;E9PEJ4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 77588000.0 21445000.0 34033000.0 22110000.0 False True 32533632.839503724 27959545.248957355 17739948.80884274 1.0 0.8594043397147976 0.5452802918247156 24.9554285928588 -6.957822384751885 0.46510801531806095 1.0087037414682063 0.38320887627330513 0.999680714242583 0.003396648069154723 0.08048836586679095 0.024076374974297505 0.004304416116902644 0.02593661532008569 1.1019899028584417e-07 6.957822384751885 -0.6254948651949012 LQPHEFQGGTFTISNLGMFGIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQPHEFQGGTFTISNLGMFGIK 22 0 P10515;H0YDD4;E9PEJ4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 30684800.0 14789000.0 6984800.0 8911000.0 False True 12297708.763786206 6947171.496025753 10774248.900191192 1.0 0.5649159229143157 0.8761183979180547 23.551886210423227 -9.950656543126605 6.288488398445415 1.0000000703997298 0.7205171604161682 0.5181610988613221 0.12704787840846124 1.2544945069756503e-07 2.098744742619222e-08 0.12301361047335402 0.0410045264372372 1.1203235283966062e-10 9.950656543126605 -0.2794829099835616 LQPHEFQGGTFTISNLGMFGIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQPHEFQGGTFTISNLGMFGIK 22 0 P10515;H0YDD4;E9PEJ4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 55764000.0 21445000.0 19215000.0 15104000.0 False True 27760975.244147606 18145668.358657513 12355226.980127325 1.0 0.6536394416648914 0.4450573825835595 24.72655491495125 -9.248840293827662 0.12635397310433993 1.6004376178139283 6.655606519172093e-09 0.9998997659530634 0.002291369789606688 0.6943034273945867 0.04519148044802605 0.34891156272006557 0.20031363500029278 5.638449643909101e-10 9.248840293827662 -1.6004376111583218 LQPIALSCVLNIGACK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQPIALSCVLNIGACK 16 0 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 0 6374700.0 1920200.0 3177500.0 1277000.0 False True 2517400.795243249 2703429.3857979923 1144868.289848965 1.0 1.073897088976159 0.45478188932499314 21.263503495508324 -6.877096465594944 1.095809135251717 1.0442618978360874 0.4132678320063762 0.971269457003452 0.046797357035095834 0.1302357815722532 0.2880613682308099 0.03297734939355675 0.07919512823797334 1.3270996492956856e-07 6.877096465594944 -0.6309940658297112 down LQPIALSCVLNIGACK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQPIALSCVLNIGACK 16 0 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 0 12753000.0 1920200.0 2608300.0 8224500.0 False True 2630149.831453837 2493056.681505336 6282042.488894456 1.0 0.9478762965101796 2.3884732397249038 21.326713557031216 -6.898505567038044 0.9706799654389465 0.937624606243103 2.5351748325695245 0.985807651978393 0.0794795897986042 0.1125132382865982 0.18369435675742765 0.061580015475584164 0.15905033993284615 1.2632649104427528e-07 6.898505567038044 1.5975502263264216 up LQPIALSCVLNIGACK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQPIALSCVLNIGACK 16 0 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 0 26250600.0 9231500.0 10651000.0 6368100.0 False True 11950358.730069894 10058262.487018535 5209171.142223832 1.0 0.8416703392936311 0.4359008176981617 23.510550590394544 -6.95492764882924 0.5018406734574468 1.007998249730945 0.252016858041351 0.9995333910028049 0.005131624275861596 0.0815653348573521 0.028225003837070477 0.005997442400031779 0.033474577688301234 1.1093596133309904e-07 6.95492764882924 -0.755981391689594 down LQPIALSCVLNIGACKLK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQPIALSCVLNIGACKLK 18 1 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 100033800.0 51358000.0 42885000.0 5790800.0 True False 49727668.4019479 60009204.1423206 4274015.759723772 1.0 1.2067568432379983 0.08594844474060145 25.567545452806357 -6.8590658152316015 1.1903331011656042 1.1119203382916107 0.032603156903815156 0.9525077955387028 0.10612871664360131 0.14776690686020405 0.3983571188095907 0.06956251504121465 0.16222492658444349 1.383356722054692e-07 6.8590658152316015 -1.0793171813877955 down LQPK(ub)QPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQPKQPLR 8 1 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;A0A0J9YXA0;A0A0J9YXE6;A0A0J9YYC6 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 1393960.0 161940.0 598460.0 633560.0 True False 221813.59426394882 572018.0583574286 483926.1765777821 1.0 2.578823269401384 2.1816795232213333 17.758988260929133 -10.296559842105166 5.365157450904508 0.9997677904256133 2.3802513963113934 0.9415374278942779 0.162133255446689 0.0004504190142770589 5.905585226043316e-05 0.15700994542700783 0.05232828318424607 5.051730315745718e-11 10.296559842105166 1.3804836058857801 LQPTWNDLGDKYNSMEDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQPTWNDLGDKYNSMEDAK 19 1 Q8NBS9 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 20049000.0 5336800.0 1752200.0 12960000.0 False True 5167386.205216624 2451862.597602287 9565387.20833393 1.0 0.47448797133201726 1.8511074706739354 22.301003282684174 -6.803242759461236 1.4426327245872579 0.711232821251997 1.8716678336990948 0.8414743329745941 0.2258395128773635 0.2161624251874511 0.8877938844004616 0.12313566443923116 0.2858219626824302 1.5731032943216362e-07 6.803242759461236 1.1604350124470977 LQQAAQQHIQQQLLAK(ub)QVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQQAAQQHIQQQLLAKQVK 19 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 44284000.0 11873000.0 17174000.0 15237000.0 True False 16262768.955760563 16415195.89317663 11638334.415865373 1.0 1.009372754285 0.7156428556247101 23.955069580827683 -6.899530221244417 0.9642492453311498 1.0123701340365179 0.6851051867025696 0.9863306610403855 0.01593682819979488 0.11175135375518737 0.1793836288463572 0.012406958687195872 0.032204803967850325 1.2602879352029577e-07 6.899530221244417 -0.3272649473339483 LQQAAQQHIQQQLLAK(ub)QVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQQAAQQHIQQQLLAKQVK 19 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 51472000.0 12991000.0 25579000.0 12902000.0 True False 10802592.098880706 25441200.849966045 15599748.547892123 1.0 2.355101499444943 1.4440745707234903 23.364874195072723 -10.434309454217177 5.791425464324519 0.9995236907282804 1.8995880350842176 0.565228876125271 0.37192518621707954 0.0022884641219292927 0.00022353096794846752 0.36029101266494706 0.12003833768781967 3.67866758736445e-11 10.434309454217177 0.9000643443559372 LQQAAQQHIQQQLLAK(ub)QVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQQAAQQHIQQQLLAKQVK 19 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 39268000.0 13899000.0 14157000.0 11212000.0 True False 17992529.490249816 13369150.504996823 9171531.04483499 1.0 0.7430389658242099 0.5097410594661 24.10089468718276 -6.9722758994637335 0.19635643524154697 1.1455639862718772 0.10079985957126011 0.9999951178162574 0.00044237292064226925 0.07557090489755366 0.006311926160719528 0.0078065177057216675 0.025000612747275656 1.0659187471058946e-07 6.9722758994637335 -1.0447641267006171 LQQIK(ub)EGPPPQNSDENR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQQIKEGPPPQNSDENR 17 1 Q9NVW2 Q9NVW2 RLIM E3 ubiquitin-protein ligase RLIM 1 5363500.0 1719300.0 1535400.0 2108800.0 True False 1664721.762597238 2148493.227005223 1556442.0173560618 1.0 1.2906019944457399 0.934956250543489 20.66684963835359 -6.689468153424175 1.8681158510091418 1.1822771141842294 0.936186620591638 0.36802884016012216 0.12291709403088717 0.4178094016707712 2.826526736152702 0.05264290686682674 0.137187365812435 2.0442398334905685e-07 6.689468153424175 -0.24609049359259139 LQQIK(ub)EGPPPQNSDENR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQQIKEGPPPQNSDENR 17 1 Q9NVW2 Q9NVW2 RLIM E3 ubiquitin-protein ligase RLIM 1 3246720.0 1453700.0 1176600.0 616420.0 True False 1991172.1747653636 1124613.921504113 470834.2915684019 1.0 0.5647999383260945 0.236460863372543 20.92518654424526 -7.994389445989799 0.28014519306591623 1.1429291674541426 1.1453131804328463e-23 0.9993890701755407 0.007729731194350738 0.10049486875843915 0.05254049970677991 0.061452627558286066 0.09203976542268427 1.0130025859499716e-08 7.994389445989799 -1.1429291674541426 down LQQIK(ub)EGPPPQNSDENR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQQIKEGPPPQNSDENR 17 1 Q9NVW2 Q9NVW2 RLIM E3 ubiquitin-protein ligase RLIM 1 6075200.0 1719300.0 2985300.0 1370600.0 True False 1429674.1279043627 2969217.596364344 1657186.1230616118 1.0 2.0768492192809465 1.1591355615357881 20.447254913787866 -10.279385243369356 4.488556882924169 0.9996430426688254 1.6179923904111042 0.3768038669250925 0.37465503192910576 0.0013509756129280424 0.0002168913840992898 0.36296442141544977 0.12091939160009708 5.255508666999248e-11 10.279385243369356 0.6183493477422788 LQQLFIQLVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQQLFIQLVLK 11 0 K7EIG7;O94832;J3QRN6;J3KRL0 K7EIG7 MYO1D Unconventional myosin-Id 0 15876300.0 3357400.0 7334400.0 5184500.0 False True 5093421.258817903 6025519.01607125 4159781.3025529254 1.0 1.183000327263265 0.8166968901995632 22.280203611687146 -6.770866450490836 1.571063125479505 1.1048482472425396 0.8145653825686237 0.7338826671300089 0.07714397236013455 0.265034885004322 1.2911346225992997 0.038700791107946456 0.0920536895806032 1.6948589048727252e-07 6.770866450490836 -0.29028286467391595 LQQLFIQLVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQQLFIQLVLK 11 0 K7EIG7;O94832;J3QRN6;J3KRL0 K7EIG7 MYO1D Unconventional myosin-Id 0 9921700.0 3357400.0 2580500.0 3983800.0 False True 4346220.484248136 2436892.906558193 3258789.2772398903 1.0 0.5606924258422101 0.74979842579331 22.051329933779595 -10.236282326184268 5.529022248497235 1.0000206489525825 0.6552454258177428 0.8158879106826364 0.07720220119655671 1.9651874926181582e-05 2.714584668855232e-06 0.07475518146008414 0.024916903293726055 5.803869968421531e-11 10.236282326184268 -0.34477522313483966 LQQLFK(ub)GSQFAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQQLFKGSQFAIR 13 1 A6NIV2;A0A087WZY2;Q9P0U1 A6NIV2 TOMM7 Mitochondrial import receptor subunit TOM7 homolog 1 8653100.0 2517500.0 3242700.0 2892900.0 True False 3300466.8795046764 2758901.7999455985 2593570.458656275 1.0 0.8359125846945769 0.7858192653778455 21.654238689887105 -13.999999999998732 0.1662060105708086 1.8196027076228325 0.7397979839995621 0.9995214315151844 0.0020010955912242 12.056832751714849 0.1290165223824325 3.1852074917572457 0.042295488202102376 1.0000000000029204e-14 13.999999999998732 -1.0798047236232704 LQQLFK(ub)GSQFAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQQLFKGSQFAIR 13 1 A6NIV2;A0A087WZY2;Q9P0U1 A6NIV2 TOMM7 Mitochondrial import receptor subunit TOM7 homolog 1 8978300.0 2517500.0 2323400.0 4137400.0 True False 3448287.782879406 2220744.5055436445 3160231.3324277326 1.0 0.644013680229806 0.9164639181561757 21.717448751409997 -9.94571324591768 6.994638858933644 1.0000000092810244 0.7802387991929902 0.4645229947365941 0.11122734386991538 1.613546235754154e-08 2.4090252500258027e-09 0.10769541662473038 0.03589847087092199 1.1331483065473216e-10 9.94571324591768 -0.21976121008803418 LQQLFK(ub)GSQFAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQQLFKGSQFAIR 13 1 A6NIV2;A0A087WZY2;Q9P0U1 A6NIV2 TOMM7 Mitochondrial import receptor subunit TOM7 homolog 1 10589200.0 3124600.0 5616500.0 1848100.0 True False 2598243.343250147 5586242.799712035 2234529.1653510667 1.0 2.1500075480706107 0.8600153527405522 21.30910512469028 -6.67158626151564 1.931639845448777 1.7330445671379382 0.8651853198656483 0.28610122855859943 0.48832109615758706 0.45751134630263623 3.2925611737185254 0.2034040820337026 0.5423448981438749 2.1301674221240404e-07 6.67158626151564 -0.8678592472722899 LQQQFNMHVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQQQFNMHVFK 11 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;Q9NQX4 G3V394;Q9NQX4 MYO5A;MYO5C Unconventional myosin-Va;Unconventional myosin-Vc 0 19598400.0 4780500.0 7554300.0 7263600.0 False True 6267281.79442786 6427227.886430759 6512032.349371134 1.0 1.0255208074647457 1.0390521063151936 22.57940843149197 -13.99999999986713 0.07917766283118562 0.8616903645949919 1.0800814931425513 0.9998899270225724 0.00016977581135827543 12.267084804085153 0.07893590006639899 0.2982960249234103 0.03730138328303152 1.0000000003059438e-14 13.99999999986713 0.21839112854755938 LQQQFNMHVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQQQFNMHVFK 11 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;Q9NQX4 G3V394;Q9NQX4 MYO5A;MYO5C Unconventional myosin-Va;Unconventional myosin-Vc 0 9867000.0 2816100.0 1442000.0 5608900.0 False True 2726704.446955203 2017798.1199306608 4139760.8266068054 1.0 0.7400135068484784 1.518228655558729 21.37872690139986 -6.8166193199665885 1.3863247170454203 0.8593674461146747 1.5340321046109726 0.876448296745488 0.11370411165730229 0.19791592078532813 0.7482894154700711 0.0644647792136415 0.14873955204802178 1.5253892451137555e-07 6.8166193199665885 0.6746646584962979 LQQQFNMHVFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQQQFNMHVFK 11 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;Q9NQX4 G3V394;Q9NQX4 MYO5A;MYO5C Unconventional myosin-Va;Unconventional myosin-Vc 0 14952400.0 2917900.0 5000100.0 7034400.0 False True 4426667.6270640185 4107793.089040384 5644047.756712958 1.0 0.9279651049303813 1.275010511791319 22.077789623178308 -6.8525778693748505 1.222734070027108 0.9614596255976429 1.2895771973068717 0.9439471910648926 0.0354043407558409 0.15465258933809303 0.44366879715895635 0.022642233570784095 0.052484365086332585 1.4041778906994553e-07 6.8525778693748505 0.32811757170922884 LQQQFNMHVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQQQFNMHVFK 11 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;Q9NQX4 G3V394;Q9NQX4 MYO5A;MYO5C Unconventional myosin-Va;Unconventional myosin-Vc 0 15390200.0 4780500.0 4549400.0 6060300.0 False True 6547980.038154928 4348392.465146017 4628981.955796347 1.0 0.6640815090773086 0.7069328142149757 22.64261849301486 -10.737302409371145 10.447570299160425 1.0005663164990226 0.6855071617304782 0.9862670941742874 0.017493972066597946 0.0002311350889947305 5.811750047773064e-06 0.016965819380371693 0.005646155206079295 1.831038983238237e-11 10.737302409371145 -0.3150591547685444 LQQQFNMHVFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQQQFNMHVFK 11 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;Q9NQX4 G3V394;Q9NQX4 MYO5A;MYO5C Unconventional myosin-Va;Unconventional myosin-Vc 0 7636800.0 2816100.0 2023700.0 2797000.0 False True 2341711.924382874 2012797.9264270016 3381839.768133174 1.0 0.8595412208773062 1.4441741244599982 21.159132176834138 -6.843272587460237 1.2671167419686233 0.9252823582508253 1.4646826021366033 0.9299383036550449 0.06595581290263713 0.1650075355242541 0.51321661305462 0.040792042269455576 0.09407556412345523 1.4345887227504025e-07 6.843272587460237 0.539400243885778 LQQQFNMHVFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQQQFNMHVFK 11 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;Q9NQX4 G3V394;Q9NQX4 MYO5A;MYO5C Unconventional myosin-Va;Unconventional myosin-Vc 0 16316800.0 2917900.0 6905300.0 6493600.0 False True 3777279.070407939 6521013.98475346 5311831.42996258 1.0 1.7263786612539598 1.4062586668739072 21.848915945270758 -10.142294834149697 4.637608907185952 0.9999424985867139 1.566318664069958 0.8066837275318928 0.1306884404815044 91351397.47990385 7.061013429487666 58154.63750959327 0.04473812928062572 7.206180993537394e-11 10.142294834149697 0.5663761654832441 LQQQK(ub)CVNGNEL ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQQQKCVNGNEL 12 1 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 1 5591530.0 1951600.0 2724200.0 915730.0 True False 2558566.499321287 2317759.9788484313 820979.0439024201 1.0 0.9058822506521778 0.320874616360451 21.286904300031626 -6.9350930283580405 0.7037408655808363 1.0074422874867415 0.18355942535922412 0.9974477819953885 0.01517737711907029 0.09007849258372773 0.0653504344302356 0.014273176977121995 0.05153181185930469 1.161199851558966e-07 6.9350930283580405 -0.8238828621275174 down LQQQK(ub)CVNGNEL ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQQQKCVNGNEL 12 1 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 1 17567400.0 6211300.0 3946800.0 7409300.0 True False 9422996.206855182 3242462.703510854 5944848.607388443 1.0 0.34410103032324035 0.6308872970853576 23.167754432291037 -10.442698835792651 6.109317391207055 1.0002018222858746 0.4874941637044234 0.8098185850380528 0.117080003134148 0.00032196881009095754 2.937035755323739e-05 0.11340594622181448 0.037787408526038915 3.608287752402673e-11 10.442698835792651 -0.5127076585814512 LQQQK(ub)CVNGNEL ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQQQKCVNGNEL 12 1 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 1 8126000.0 3158500.0 3175800.0 1791700.0 True False 2626432.6952747796 3158691.335053054 2166336.1861151997 1.0 1.202654589525885 0.8248207502185986 21.324673183918673 -6.761054310638681 1.6089197491125793 1.117561457799322 0.8233881770736713 0.6950948788456739 0.08524913871335821 0.2811510872723831 1.4347149682471756 0.04180468094795401 0.1003421512470401 1.7335871906824375e-07 6.761054310638681 -0.29417328072565074 LQQQK(ub)CVNGNEL ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQQQKCVNGNEL 12 1 Q9BTE3-2;Q9BTE3;Q9BTE3-3 Q9BTE3-2 MCMBP Mini-chromosome maintenance complex-binding protein 1 17048200.0 6211300.0 5408000.0 5428900.0 True False 8040650.293027462 5107040.045985932 4440895.905218044 1.0 0.6351526132674316 0.5523055652686469 22.938880754383487 -13.999999999999998 0.20829881131322905 3.0954285724267083 0.5026963170177883 0.999489126594035 0.00439576649402864 12.707425870558964 0.14467082433751832 10.88875197430483 0.04966610131970266 1.0000000000000041e-14 13.999999999999998 -2.59273225540892 LQQQLQDIK(ub)EQTMCPVCLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQQQLQDIKEQTMCPVCLDR 20 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 6907300.0 1540200.0 0.0 5367100.0 True False 2019217.1153180192 0.0 4811763.976858549 1.0 0.0 2.382984940230518 20.945364613402173 -6.792711531625644 1.4855424777400508 0.4430679187438976 2.41024349732882 0.8099931912138378 0.42588453889021716 0.2313185933382275 1.008400567798105 0.2256257367255818 0.5272071010555883 1.6117158184003238e-07 6.792711531625644 1.9671755785849223 LQQQLQDIK(ub)EQTMCPVCLDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQQQLQDIKEQTMCPVCLDR 20 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 11879900.0 1540200.0 3268600.0 7071100.0 True False 2109653.562339969 3124182.44418523 5401051.813875802 1.0 1.480898333241015 2.560160544978345 21.008574674925065 -6.957730747503293 0.4663215902380851 0.9704506758584495 3.1145791968678522 0.9996765365418351 0.011732765492013533 0.08052201214350053 0.024204167209290684 0.014821475312554218 0.08910303992483423 1.1022224500850397e-07 6.957730747503293 2.144128521009403 LQQQLQDIK(ub)EQTMCPVCLDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQQQLQDIKEQTMCPVCLDR 20 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 20076700.0 5410000.0 9587900.0 5078800.0 True False 7003351.647043069 9054324.936558539 4154510.512888685 1.0 1.2928559628133802 0.5932174653321582 22.73961409814251 -6.7929854244511 1.484210407002737 1.1630431490859827 0.5851331219964391 0.8109125692009499 0.12474990962242863 0.23092310683961798 1.0048234513915313 0.06614509624679654 0.1545436037211345 1.6106996916748273e-07 6.7929854244511 -0.5779100270895436 LQQQQRPEDAEDGAEGGGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQQQQRPEDAEDGAEGGGKR 20 2 Q08J23-2;Q08J23;A0A140T9Y7 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 1 35483200.0 5174100.0 4934100.0 25375000.0 True False 6697974.446758877 4659512.99757751 20757010.369486935 1.0 0.6956600140259164 3.098998142569978 22.675293441396786 -6.875130175046418 1.1066585447680444 0.8212064410219176 3.2541445741125754 0.9695376830677297 0.18648311144630564 0.13202824953524558 0.2991327412985767 0.13033109835497592 0.3116103338182465 1.3331217835190898e-07 6.875130175046418 2.4329381330906577 up LQQQTK(ub)EGAGGGAGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQQQTKEGAGGGAGTR 16 1 F5H0R1;Q9H6E5 F5H0R1 TUT1 Speckle targeted PIP5K1A-regulated poly(A) polymerase 1 7869900.0 1967000.0 2677600.0 3225300.0 True False 2578756.048455093 2278112.517203055 2891576.8952622265 1.0 0.8834152879904438 1.1213068785605143 21.298243869271488 -6.773476108560518 1.5614437971776833 0.933426498528197 1.122814698128305 0.7435689828241534 0.04918325402719957 0.26084875786491724 1.255619826389381 0.02482248773585878 0.05889427351778019 1.684705103343981e-07 6.773476108560518 0.1893881996001079 LQQQTK(ub)EGAGGGAGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQQQTKEGAGGGAGTR 16 1 F5H0R1;Q9H6E5 F5H0R1 TUT1 Speckle targeted PIP5K1A-regulated poly(A) polymerase 1 9229300.0 2690800.0 2377700.0 4160800.0 True False 2605382.0268694526 3327128.0095416973 3070961.6586756003 1.0 1.2770211720311408 1.178699180006847 21.313063499547983 -10.105089566946692 4.3032823030003255 0.999969218403608 1.2278601760416217 0.8774661381887598 0.040139785247481234 27954839.119362935 0.5884266143955675 8893.783071595504 0.013740916132752424 7.850737078316688e-11 10.105089566946692 0.2278909576380137 LQQQTK(ub)EGAGGGAGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQQQTKEGAGGGAGTR 16 1 F5H0R1;Q9H6E5 F5H0R1 TUT1 Speckle targeted PIP5K1A-regulated poly(A) polymerase 1 7161900.0 1967000.0 2648600.0 2546300.0 True False 2694253.056176282 2531576.094251055 1944916.3826946244 1.0 0.9396207562788849 0.7218759122258821 21.36145393079438 -6.9472576505869545 0.5881852897959131 1.0025307361314122 0.6480435028476561 0.9989680872105612 0.0038370872512734555 0.08460608703826362 0.04066714492584259 0.0039855263032164195 0.018231746381677523 1.1291258480184613e-07 6.9472576505869545 -0.3544872332837561 LQQQTK(ub)EGAGGGAGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQQQTKEGAGGGAGTR 16 1 F5H0R1;Q9H6E5 F5H0R1 TUT1 Speckle targeted PIP5K1A-regulated poly(A) polymerase 1 8605100.0 2690800.0 3732500.0 2181800.0 True False 2237519.422651696 3712392.2816567607 2638004.2924965927 1.0 1.6591553324963701 1.1789860976358721 21.09346877498226 -10.449663952324931 4.852812726723409 0.9991054398721783 1.4190707150661854 0.5038709717201063 0.19602826926536146 0.0019011031303478997 0.00021559564945398957 0.19018951791183147 0.06326785185418572 3.550880424051769e-11 10.449663952324931 0.41996527519400717 LQQSFPGIEVTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQQSFPGIEVTVK 13 0 O75792 O75792 RNASEH2A Ribonuclease H2 subunit A 0 9646900.0 3582800.0 2685800.0 3378300.0 False True 3469065.97512557 3758253.946261971 2493421.8831724133 1.0 1.0833619115952193 0.7187588535505322 21.726115847562014 -6.846575464778306 1.2515007620223755 1.0443862119488252 0.705117902305502 0.9351770946873135 0.039714251655489766 0.16126001969403253 0.4877650776269566 0.02485185874848261 0.05739689291199523 1.4237198337931852e-07 6.846575464778306 -0.3392683096433232 LQQSFPGIEVTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQQSFPGIEVTVK 13 0 O75792 O75792 RNASEH2A Ribonuclease H2 subunit A 0 27461800.0 4952900.0 15206000.0 7302900.0 False True 7513911.405492095 12492370.49497973 5859478.614025225 1.0 1.6625655828000263 0.7798173677882858 22.841132674975043 -6.70581945526749 1.809834707449338 1.4090457997984458 0.7821077343620236 0.44539654514054317 0.27938944415911027 0.38351694087548654 2.4460024096183552 0.12296503598805161 0.3140147748673057 1.9687045486984963e-07 6.70581945526749 -0.6269380654364222 LQQSFPGIEVTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQQSFPGIEVTVK 13 0 O75792 O75792 RNASEH2A Ribonuclease H2 subunit A 0 6013090.0 959990.0 2149700.0 2903400.0 False True 1314924.2457542832 2054719.145892731 2217676.7173999795 1.0 1.5626140840638902 1.6865433309641715 20.326548255972757 -11.505232638112087 0.26468047889504 1.236591641492566e-12 1.7359945829763335 0.9993176696153769 0.007803640303060035 3.9547611096705793 0.1460102578763647 2.312484210499494 0.05269353069765231 3.124405271583027e-12 11.505232638112087 1.735994582975097 LQQSFPGIEVTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQQSFPGIEVTVK 13 0 O75792 O75792 RNASEH2A Ribonuclease H2 subunit A 0 7841600.0 3582800.0 2068300.0 2190500.0 False True 2979256.9449518747 2057157.6573745918 2648523.422272335 1.0 0.6904935342553417 0.888987915849305 21.50652112299629 -10.7570241322953 5.730973846076963 1.0085166111247912 0.7897407250524109 0.5993706014246106 0.08103499195241723 0.009061282621010198 0.0003841704486186547 0.08062659410077012 0.026153931190980324 1.7497494581840903e-11 10.7570241322953 -0.2187758860723803 LQQSFPGIEVTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQQSFPGIEVTVK 13 0 O75792 O75792 RNASEH2A Ribonuclease H2 subunit A 0 18574300.0 4952900.0 7012100.0 6609300.0 False True 6411626.686255009 6621870.470868704 5406475.217144836 1.0 1.0327910208909086 0.8432298824781896 22.612258997067492 -6.862308454110432 1.174102210201017 1.0179105413418397 0.8336412551531802 0.9563778323261273 0.01727713558684521 0.14444081965106742 0.377064675817147 0.011466356979587826 0.026837765104548213 1.3730664193978946e-07 6.862308454110432 -0.18426928618865945 LQQSHPLSATQIQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQQSHPLSATQIQVK 15 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 12759000.0 3951800.0 5119000.0 3688200.0 False True 5180848.069285634 4355265.153705712 3306580.4437125665 1.0 0.8406471480076122 0.6382315017719671 22.304756845847496 -6.967872639132586 0.30474578692183013 1.0331833558075187 0.43930961376049615 0.9999607099221871 0.0009279217217041296 0.07699918787330716 0.011487895404031279 0.0032816070686736932 0.018064581656925736 1.076780943287663e-07 6.967872639132586 -0.5938737420470226 LQQSHPLSATQIQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQQSHPLSATQIQVK 15 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 8287300.0 3479400.0 0.0 4807900.0 False True 3368948.3515272727 0.0 3548566.7560917153 1.0 0.0 1.0533158676899914 21.68386688037018 -10.523617093745484 5.036964866817768 1.001886475373554 0.5266579338449853 0.21213929754502658 0.4300144023029372 0.009141613796706628 0.000864588124237197 0.4178175933992232 0.1387865515623789 2.994904002598104e-11 10.523617093745484 -0.47522854152856864 LQQSHPLSATQIQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQQSHPLSATQIQVK 15 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 13271200.0 3951800.0 4602600.0 4716800.0 False True 5412887.25337948 4399241.913237148 3602788.9855453023 1.0 0.8127348136598498 0.6655946848506661 22.367966907370388 -6.973834343644002 0.13879020757699095 1.2005292720397538 0.27396596581772975 0.9999989628092747 0.00013924945946044214 0.07507704316755305 0.00419850490162866 0.008422998070977558 0.019268443233424633 1.0621006053210926e-07 6.973834343644002 -0.926563306222024 LQQTEAELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQQTEAELR 9 0 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 6691910.0 1394900.0 673510.0 4623500.0 False True 1350619.6630296577 942446.0553082512 3412466.6479731374 1.0 0.6977878977373931 2.5265933418431246 20.365190035614244 -6.864459194851111 1.1629285540686598 0.8336365225191597 2.6230311264700052 0.958837730763222 0.1623973176433603 0.14228245346710783 0.36313265772555847 0.1086974939502015 0.25515898707571366 1.366283442000722e-07 6.864459194851111 1.7893946039508455 up LQQTLNALNK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQQTLNALNKK 11 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 1 3533020.0 819120.0 1009900.0 1704000.0 True False 793117.4839636192 1413158.3365589278 1257671.2810957562 1.0 1.781776804990659 1.5857313784214173 19.59717506164929 -10.087435092739836 4.5145804081997865 0.9999548896930829 1.6837540917340466 0.9419247572140883 0.08003521045093438 55642115.34204071 3.1178613669747657 30011.258229325023 0.027398181318207086 8.17645229562903e-11 10.087435092739836 0.6837992020409637 LQQTYAALNSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQQTYAALNSK 11 0 P46940;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 7094800.0 1613200.0 2744000.0 2737600.0 False True 2114920.8222510233 2334605.8960282234 2454339.4129134887 1.0 1.1038738998954 1.1604876112105247 21.012172222511474 -13.999996588339165 0.07377363814453333 0.4161263253001085 1.3509022536626893 0.9999110441818931 0.0006267906010886916 12.32135698849662 0.07456178207140335 1.2113146823843255 0.17438564302526233 1.000007855670236e-14 13.999996588339165 0.9347759283625808 LQQTYAALNSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQQTYAALNSK 11 0 P46940;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 5899600.0 1613200.0 1843700.0 2442700.0 False True 2209643.6350907907 1762239.2376994134 1865784.56898565 1.0 0.7975219215052322 0.8443825689154568 21.075382284034365 -10.761763881722139 6.940807915201253 1.003975737881343 0.8209522452103467 0.9511366723530261 0.01913077919525407 0.0011982839537861252 4.1129807057186914e-05 0.018858873655987964 0.0061744324352658525 1.7307570856762238e-11 10.761763881722139 -0.18302349267099627 LQQVAEK(ub)YYGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQQVAEKYYGNK 12 1 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 1 16452600.0 6511900.0 6354000.0 3586700.0 True False 6305183.298933841 8891185.335672254 2647235.6713064294 1.0 1.4101390735421897 0.41985070786983414 22.588106881292255 -6.794209805764858 1.4793539563762617 1.227971609002202 0.4080421448531313 0.8147389504682623 0.17486425367812472 0.22911436660490103 0.9903884534287941 0.093017027579917 0.2171382255577274 1.606165134206261e-07 6.794209805764858 -0.8199294641490706 down LQQVDGFEK(ub)PK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQQVDGFEKPK 11 1 B8ZZE3;B8ZZC8;Q9NRN9;B8ZZY8;E7EMN2;F5H4E8 B8ZZE3 METTL5 Methyltransferase-like protein 5 1 3270210.0 800910.0 1085000.0 1384300.0 True False 1050000.7660234729 923122.2292968752 1241065.9151432416 1.0 0.8791633865115092 1.1819666759324035 20.001958949727822 -6.798403397301481 1.4623315870304372 0.9331933460213169 1.1859880436527361 0.8274797022404894 0.051693412074402555 0.22304413065384507 0.9417811602086216 0.027811373685086543 0.06474553918405583 1.5907304800918758e-07 6.798403397301481 0.25279469763141926 LQQVDGFEK(ub)PK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQQVDGFEKPK 11 1 B8ZZE3;B8ZZC8;Q9NRN9;B8ZZY8;E7EMN2;F5H4E8 B8ZZE3 METTL5 Methyltransferase-like protein 5 1 4483710.0 800910.0 1190100.0 2492700.0 True False 1097028.0707789266 1137517.4468655812 1903975.598767975 1.0 1.0369082406960706 1.735576007108085 20.065169011250713 -6.917831118455491 0.8406400173719433 0.9833475852321655 1.8428133438747023 0.9935574721330465 0.027161004780745547 0.09946428318220663 0.112344864960744 0.023137294553670845 0.06793474643007219 1.208283601910997e-07 6.917831118455491 0.8594657586425368 LQQVLQMESHIQSTSDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQQVLQMESHIQSTSDR 17 0 Q14974;Q14974-2;J3KTM9;J3QKQ5 Q14974 KPNB1 Importin subunit beta-1 0 13424100.0 2329700.0 7287500.0 3806900.0 False True 3054259.2608468905 6200233.406452516 3412998.5063633705 1.0 2.0300285198229386 1.1174554007628705 21.54239109984882 -6.617088304430824 2.127934806228894 1.6848708842331093 1.1209171001425446 0.07288711263274972 0.44328431182336264 0.5933189147148787 5.1012066092977735 0.17143334519955047 0.49153887401260193 2.4149697524258094e-07 6.617088304430824 -0.5639537840905646 LQQVLQMESHIQSTSDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQQVLQMESHIQSTSDR 17 0 Q14974;Q14974-2;J3KTM9;J3QKQ5 Q14974 KPNB1 Importin subunit beta-1 0 6590400.0 1444300.0 1074000.0 4072100.0 False True 1398451.4870698506 1502853.8008360122 3005494.84961856 1.0 1.0746556564396195 2.1491591788542608 20.415398776246814 -6.920937836207716 0.8177431906703373 0.9770839548993467 2.3262251185016463 0.9944374729457868 0.039156310722294474 0.09762299962594134 0.10277848296296051 0.03390581558803517 0.10249238118187293 1.1996710086750975e-07 6.920937836207716 1.3491411636022996 up LQQVLQMESHIQSTSDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQQVLQMESHIQSTSDR 17 0 Q14974;Q14974-2;J3KTM9;J3QKQ5 Q14974 KPNB1 Importin subunit beta-1 0 7872500.0 2329700.0 2925300.0 2617500.0 False True 3191053.0477752355 2796050.5733265174 1999300.4091046539 1.0 0.8762156352354878 0.6265331159250213 21.605601161371712 -6.959878201010869 0.4371471215002989 1.0091978318865293 0.48386212906870796 0.9997656536914358 0.0023778140206821936 0.07974465704327613 0.02129230951847005 0.0032806306440342635 0.02069929230083632 1.0967857493597697e-07 6.959878201010869 -0.5253357028178214 LQQYFPK(ub)APEFPSYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQQYFPKAPEFPSYK 15 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;A0A0A0MRS6;Q86UV5-5 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 13804300.0 3887100.0 3881900.0 6035300.0 True False 3763706.13819097 5431962.913841067 4454473.874881003 1.0 1.4432484137701427 1.1835339187830567 21.843722559365965 -10.213141918901526 4.763160978635932 0.9999440067713405 1.3133911662776325 0.6600283354524762 0.10602799859084076 6.305932230963209e-05 1.0417239844597723e-05 0.10267947228703944 0.03422038939731387 6.12150320342717e-11 10.213141918901526 0.313447159506292 LQQYFPK(ub)APEFPSYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQQYFPKAPEFPSYK 15 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;A0A0A0MRS6;Q86UV5-5 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 13704500.0 3887100.0 4010900.0 5806500.0 True False 3232295.8777275975 3989292.4855986857 7020612.303777369 1.0 1.2341978075358868 2.1720203129154974 21.62412783480024 -6.944849243985045 0.6127898279957616 0.9896649705981471 2.4656265237431683 0.9987325538064414 0.01802854052492338 0.08562232929558428 0.045046858627462674 0.018277517257735767 0.07915801825729762 1.1354048787253862e-07 6.944849243985045 1.4759615531450212 up LQQYYIFIPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQQYYIFIPSK 11 0 Q9H0S4;Q9H0S4-2;F5H1N9 Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 0 8601900.0 2387600.0 2071800.0 4142500.0 False True 3130166.7215512875 1762695.5158131479 3713873.837665882 1.0 0.5631315110715793 1.1864779636483112 21.5778080705554 -6.718286376330623 1.7653963630117504 0.7337425337629561 1.185424251910884 0.5045732201427997 0.1838736379231801 0.358597785410734 2.1832285992800124 0.08272921819760241 0.20810771716581886 1.9129940695108662e-07 6.718286376330623 0.4516817181479279 LQQYYIFIPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQQYYIFIPSK 11 0 Q9H0S4;Q9H0S4-2;F5H1N9 Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 0 6869210.0 1876200.0 938510.0 4054500.0 False True 1816641.0579799563 1313261.9372649938 2992504.8176072435 1.0 0.7229066697002307 1.647273579148766 20.792841961362825 -6.8263389764542115 1.3441008895752233 0.8515204706709467 1.670352396150523 0.8983626169188174 0.1234821576805117 0.18537772715521106 0.6562460096227839 0.07215625604094687 0.16610643499497968 1.4916297051042054e-07 6.8263389764542115 0.8188319254795764 LQQYYIFIPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQQYYIFIPSK 11 0 Q9H0S4;Q9H0S4-2;F5H1N9 Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 0 6789200.0 2387600.0 1588600.0 2813000.0 False True 3270360.2424639007 1518410.399202307 2148627.3355535427 1.0 0.4642945384078946 0.6570002006674224 21.64101813207829 -10.083011767860347 5.038522571643714 1.0000105328845843 0.560647369536008 0.8739075085151777 0.07867175718589263 9.308490042642446e-06 1.6941818965467106e-06 0.07617542539955768 0.025391200448998306 8.260155671432783e-11 10.083011767860347 -0.4393631633485763 LQREEEEAFASSQSSQGAQSLTFSK(ub)FEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQREEEEAFASSQSSQGAQSLTFSKFEEK 29 2 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;V9GYI8 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 56601000.0 19165000.0 15609000.0 21827000.0 True False 25125500.59412399 13280198.043405455 19568551.41936829 1.0 0.5285545652575474 0.778832300119215 24.58264900468084 -10.036328121949913 5.101920972602464 1.000004196458786 0.6536934326867233 0.7185313813956923 0.10217545740421415 4.877141309666585e-06 9.211862554443249e-07 0.0989321595015881 0.0329769870756424 9.197544083161314e-11 10.036328121949913 -0.3463107637720627 LQREEEEAFASSQSSQGAQSLTFSK(ub)FEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQREEEEAFASSQSSQGAQSLTFSKFEEK 29 2 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;V9GYI8 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 96597000.0 34426000.0 25588000.0 36583000.0 True False 33333165.473839693 35805421.83965717 27000814.833524678 1.0 1.0741680644689369 0.8100285241350772 24.99045499325768 -6.831729418999009 1.3200680707538606 1.0395863592667103 0.8026614955019525 0.9093048915715484 0.03349922926618404 0.17868819936003166 0.6083466694734153 0.019920720162496245 0.04584458183272489 1.4732300916158523e-07 6.831729418999009 -0.23692486376475774 LQREEEEAFASSQSSQGAQSLTFSK(ub)FEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQREEEEAFASSQSSQGAQSLTFSKFEEK 29 2 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;V9GYI8 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 1229007000.0 258710000.0 549782000.0 420515000.0 True False 392481984.2344613 451669106.6336281 337400025.9317282 1.0 1.1508021381277198 0.8596573587698023 28.54805119182388 -6.76590534867523 1.5899172890955773 1.0869453816581265 0.8582585543005573 0.7147576049156065 0.06349416510259241 0.2730889667165522 1.3616786393504265 0.03148914127170846 0.07524870826777737 1.7143308927507948e-07 6.76590534867523 -0.22868682735756918 LQREEEEAFASSQSSQGAQSLTFSK(ub)FEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQREEEEAFASSQSSQGAQSLTFSKFEEK 29 2 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;V9GYI8 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 85838000.0 19165000.0 39436000.0 27237000.0 True False 26250818.41465098 37693587.1225873 20804181.56362312 1.0 1.4359014079938146 0.7925155412302113 24.64585906620373 -6.724246615342245 1.7440870619135211 1.263991094651223 0.7932754708370975 0.5324252385696396 0.18334039602533453 0.34714597475559716 2.065882639244369 0.08339651461574224 0.2083139255596745 1.8869195522422545e-07 6.724246615342245 -0.47071562381412546 LQREEEEAFASSQSSQGAQSLTFSK(ub)FEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQREEEEAFASSQSSQGAQSLTFSKFEEK 29 2 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;V9GYI8 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 109160000.0 34426000.0 53172000.0 21562000.0 True False 28626744.330387745 52885551.88218435 26070514.508576207 1.0 1.84741762010448 0.9107048362779396 24.770860268691955 -6.668490885914484 1.9430002151647083 1.5416197029867593 0.9145414094309192 0.2722233631215032 0.36009338061723906 0.464615782589282 3.380247564524256 0.1492865531554466 0.39960241443139516 2.1454041387032397e-07 6.668490885914484 -0.6270782935558401 LQREEEEAFASSQSSQGAQSLTFSK(ub)FEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQREEEEAFASSQSSQGAQSLTFSKFEEK 29 2 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;V9GYI8 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 1090933000.0 258710000.0 557012000.0 275211000.0 True False 334905194.9365092 526013792.5471005 225125421.90332514 1.0 1.5706349154924915 0.6722064193301154 28.31917751391633 -6.735090077660283 1.704651983576099 1.3414420654847046 0.6722215865735004 0.5827125948561074 0.2398006778104274 0.32677325025418547 1.8624317208916872 0.11137715179390284 0.27479858231239446 1.8403902438197033e-07 6.735090077660283 -0.6692204789112042 LQSGICHLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQSGICHLFR 10 0 P14868;P14868-2;C9J7S3;C9JLC1 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 21368800.0 6826600.0 5694000.0 8848200.0 False True 8949738.70888845 4844477.395038164 7932673.141927637 1.0 0.541298193457521 0.886358071442833 23.093414132271615 -9.89781346912819 5.957192437823917 1.0000000777480795 0.7138281324500149 0.47837132560239326 0.14087010529575075 1.4538473766484447e-07 2.6953197026715254e-08 0.13639692953132324 0.04546563098232607 1.265279672457193e-10 9.89781346912819 -0.28617194529806467 LQSGICHLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQSGICHLFR 10 0 P14868;P14868-2;C9J7S3;C9JLC1 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 8181000.0 4549900.0 1805800.0 1825300.0 False True 4405465.914989341 2526865.357122596 1347199.1721737576 1.0 0.5735750555974304 0.3058017467777905 22.070863173645655 -8.524110004362868 0.2010395280506743 1.3172602569098428 6.948818962908636e-11 0.9996975099947489 0.0049717711720551234 0.16828837882837241 0.051805252826182625 0.15440193825729698 0.1265886372945035 2.9915068086949925e-09 8.524110004362868 -1.3172602568403546 down LQSGICHLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQSGICHLFR 10 0 P14868;P14868-2;C9J7S3;C9JLC1 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 12800100.0 6032100.0 6768000.0 0.0 False True 9151136.705580339 5560197.521374643 0.0 1.0 0.6075963784896853 0.0 23.1255195277644 -7.63309397672956 0.6672777542152035 0.9976586746964554 2.133919185233673e-21 0.9872147413784346 0.04651632571220837 0.12114120195509673 0.14805792531955128 0.04247619252385962 0.07744604458138293 2.3275875378578156e-08 7.63309397672956 -0.9976586746964554 down LQSGICHLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQSGICHLFR 10 0 P14868;P14868-2;C9J7S3;C9JLC1 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 24113700.0 6826600.0 10165000.0 7122100.0 False True 9350578.501928343 9715876.688840134 5440006.664253772 1.0 1.0390669076610026 0.581782898580221 23.156624193794507 -6.88612213260444 1.0450254778843753 1.0269026684352802 0.5453117908447749 0.97829887046257 0.030489820827114517 0.12234694422146548 0.24066633099565535 0.02233568410724327 0.05496117770525529 1.299803994822973e-07 6.88612213260444 -0.48159087759050534 LQSGICHLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQSGICHLFR 10 0 P14868;P14868-2;C9J7S3;C9JLC1 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 7784000.0 4549900.0 1094100.0 2140000.0 False True 3783443.4447461534 1088205.8661381544 2587464.1057579564 1.0 0.28762313538723094 0.6838913131768936 21.85126844907993 -10.756105535233278 6.874906009187738 1.0108247201605483 0.4857572242835485 0.6918730548259601 0.16177580614785989 0.026623916069374007 0.0009445101606281767 0.15537183034842775 0.05221291691916175 1.753454353898618e-11 10.756105535233278 -0.5250674958769997 LQSGICHLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQSGICHLFR 10 0 P14868;P14868-2;C9J7S3;C9JLC1 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 14518200.0 6032100.0 3137700.0 5348400.0 False True 7808672.360467369 2963084.2367400248 4375046.079218283 1.0 0.37946069446338976 0.5602804007205683 22.89664584985685 -10.923042682280741 11.61948694089321 1.0676359173410812 0.4698705475919805 0.9197476759784692 0.073819335961671 0.0341414098303434 0.00022612244941102946 0.018866906176795012 0.023825088233970178 1.1938707655769218e-11 10.923042682280741 -0.5977653697491008 LQSGQFGDVGFNPYEPAVDFFSGDVMIHPVTNRPADK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQSGQFGDVGFNPYEPAVDFFSGDVMIHPVTNRPADKR 38 2 Q14137;Q14137-2;A0A075B729 Q14137 BOP1 Ribosome biogenesis protein BOP1 1 40002000.0 10753000.0 13738000.0 15511000.0 True False 13919970.473318692 12973468.223327428 12688157.156299984 1.0 0.9320040044764831 0.9115074762996226 23.73065281519402 -13.999999999999524 0.16802758127640058 1.3411713190605856 0.89304225283913 0.9995175583677623 0.0008307219103035842 12.072884442340406 0.1297641360794507 1.342321453501045 0.017015423725618924 1.0000000000010962e-14 13.999999999999524 -0.44812906622145565 LQSIGTENTEENR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQSIGTENTEENR 13 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 56659800.0 1363800.0 28623000.0 26673000.0 False True 1787955.0070579862 24352559.971580144 23913133.825482678 1.0 13.620342724200526 13.374572475864957 20.7698790016446 -9.906236307631938 6.32343423605213 0.9999984847693881 13.497457600034 0.9997100316565058 0.10033528373438086 2.1440759867394118e-06 3.6812268052206836e-07 0.09714923226545036 0.03238307357769127 1.2409768854588583e-10 9.906236307631938 12.497459115264611 LQSIGTENTEENR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQSIGTENTEENR 13 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 54276800.0 14496000.0 6098800.0 33682000.0 False True 14035832.414709242 8534082.644821841 24859673.761659198 1.0 0.6080211271173566 1.7711577786869848 23.742611291650228 -6.815800875600153 1.389911151247173 0.7877866795107997 1.7943410404819826 0.8744577643753859 0.17120218185985686 0.19899555388180903 0.7564805780122569 0.09682017176010146 0.22344656193889015 1.5282666092013396e-07 6.815800875600153 1.006554360971183 LQSIGTENTEENR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQSIGTENTEENR 13 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 51696800.0 1363800.0 25081000.0 25252000.0 False True 1868033.7153092101 23972838.48822425 19287997.68126483 1.0 12.833193690112866 10.325294197418778 20.833089063167492 -10.151842901676245 10.616611363215949 0.9999999895431946 11.579243943765821 0.9595570294770763 1.0238456805475509 2.560990871876835e-07 2.2262519612537055e-08 0.9913343174616996 0.33044477248725534 7.049480252926557e-11 10.151842901676245 10.579243954222626 LQSIGTENTEENR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQSIGTENTEENR 13 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 5954900.0 1346900.0 2749400.0 1858600.0 False True 1743588.601368265 2596393.47308316 1520353.8708464412 1.0 1.4891089968388553 0.8719682324450605 20.73362824660588 -6.695488264626828 1.8468045319953355 1.3050493055777035 0.87394348451562 0.39624452994975856 0.20663434455469598 0.40499613791061573 2.6821538147494084 0.08936752146203282 0.23113156302434215 2.016098448326338e-07 6.695488264626828 -0.4311058210620835 LQSIGTENTEENRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQSIGTENTEENRR 14 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 99068600.0 2381600.0 56743000.0 39944000.0 False True 3122300.6634472054 48277165.58248164 35810978.0499037 1.0 15.462048914014828 11.469420119959317 21.574178038343632 -9.67321997447136 8.143238937991013 1.0001652825862914 13.465734516987105 0.9285581803909391 1.6299838824233976 0.0 0.0 1.5782250124868762 0.5260750355136238 2.1221692898938192e-10 9.67321997447136 12.465569234400814 LQSIGTENTEENRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQSIGTENTEENRR 14 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 97810300.0 26194000.0 8507300.0 63109000.0 False True 25362485.807870712 11904309.254983423 46578859.67058229 1.0 0.4693668177939077 1.8365258052161244 24.59619281690238 -6.801461152663673 1.449963688532091 0.7077656496831396 1.8560806354296902 0.8363915651291876 0.2276354416354266 0.21868052038857105 0.9075112182868655 0.12349831160465807 0.2869566052881388 1.5795698928368497e-07 6.801461152663673 1.1483149857465507 LQSIGTENTEENRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQSIGTENTEENRR 14 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 97518600.0 2381600.0 49260000.0 45877000.0 False True 3262141.880319998 47083530.31896358 35041797.46647347 1.0 14.433317754513162 10.74195996129882 21.637388099866524 -9.683564443894575 11.244170323944589 1.0000000000024678 12.587638860918398 0.929272738692523 1.506990508570213 0.0 0.0 1.45913728564627 0.4863790952154233 2.0722185453324525e-10 9.683564443894575 11.58763886091593 LQSIGTENTEENRR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQSIGTENTEENRR 14 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 28314100.0 26194000.0 1103900.0 1016200.0 False True 21781471.590953838 1097953.071593005 1228682.7216220712 1.0 0.05040766263235404 0.05640953672443147 24.376598092336657 LQSIGTENTEENRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQSIGTENTEENRR 14 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 13011400.0 2216700.0 5475000.0 5319700.0 False True 2869561.847689534 5170311.4370882055 4351569.184731418 1.0 1.8017773135822637 1.5164577087736033 21.452399038482245 -10.067187700671761 4.973955049338323 0.9999848925963939 1.6591175111819902 0.876777954522144 0.11648124091301448 1.9514871150655915e-05 3.6600618893957122e-06 0.11278505785875517 0.037594158848130804 8.566675162762245e-11 10.067187700671761 0.6591326185855964 LQSK(ub)EYSQY ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQSKEYSQY 9 1 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 1 2748210.0 1034300.0 907380.0 806530.0 True False 1355977.3161754464 772002.4409395383 723078.0123820562 1.0 0.5693328581019205 0.5332522924657089 20.37090161349539 -13.999999999999998 0.3512605409115464 6.337601627326549 0.5283503205760449 0.9997571031803896 0.0033045910578775963 20.78598044330028 0.19087682414288853 82.83344048110705 0.010718969888884327 1.0000000000000041e-14 13.999999999999998 -5.809251306750504 LQSK(ub)EYSQY ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQSKEYSQY 9 1 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 1 3954700.0 1178700.0 1157400.0 1618600.0 True False 1141282.8136877588 1619555.8557612654 1194640.1030408402 1.0 1.4190661914272515 1.0467520308841516 20.12222490989647 -10.467535088736582 6.60686065913068 0.9999293251339416 1.2329091111557016 0.3428774656244177 0.1519966195572088 0.00015828038301109523 1.2756433142619302e-05 0.14721458227485323 0.049056698018741206 3.407727910179822e-11 10.467535088736582 0.23297978602175995 LQSK(ub)EYSQY ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQSKEYSQY 9 1 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 1 4917500.0 1178700.0 2457400.0 1281400.0 True False 980141.2752636955 2444161.49844429 1549334.815475816 1.0 2.4936828599394683 1.5807260183579 19.902630185330747 -10.489959339659029 8.783953842067294 0.9999656704484483 2.0372044391486797 0.6324806187372668 0.3727130698429631 0.0002505945563139563 1.4551013176943001e-05 0.36088964735285584 0.12029262603463647 3.2362395444644985e-11 10.489959339659029 1.0372387687002314 LQSK(ub)IEDMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQSKIEDMR 9 1 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 25868700.0 7731500.0 12951000.0 5186200.0 True False 10136071.371952506 11018761.282602604 4649581.773543218 1.0 1.0870840267652995 0.4587163608978783 23.27299525240584 -6.871858667036393 1.1242730704134305 1.049846611472613 0.4206015090555028 0.9665004511204447 0.050876946559191276 0.13508231001837614 0.3179922620385621 0.035080137304316326 0.08332881475135084 1.3432020098278952e-07 6.871858667036393 -0.6292451024171102 down LQSK(ub)IEDMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQSKIEDMR 9 1 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 46813900.0 14863000.0 28889000.0 3061900.0 True False 12359243.042542046 28733369.22298246 3702129.133373966 1.0 2.324848627385888 0.299543355578556 23.559087050478716 -6.730176771202294 1.722325870943185 1.7971052617879257 0.30064586250981773 0.5602366113747348 0.5569257865604602 0.3358882889745413 1.9520353846408725 0.2562256846612661 0.6357424912101843 1.861329364195293e-07 6.730176771202294 -1.4964593992781081 LQSLK(ub)AER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQSLKAER 8 1 Q96R06;J3KTQ0;J3QS12 Q96R06 SPAG5 Sperm-associated antigen 5 1 3003010.0 669010.0 1158700.0 1175300.0 True False 877078.5887020564 985826.4765772254 1053691.2302736796 1.0 1.1239887614131583 1.201364671132815 19.742346592421544 LQSLK(ub)AER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQSLKAER 8 1 Q96R06;J3KTQ0;J3QS12 Q96R06 SPAG5 Sperm-associated antigen 5 1 3778700.0 1323700.0 1345400.0 1109600.0 True False 1281679.8680567474 1882625.236168313 818962.4727135284 1.0 1.4688732210662752 0.6389758418810306 20.289604526723995 -6.753428983170789 1.6370945358153008 1.2745676008144515 0.6368819692564034 0.6635702803446575 0.19706746368435524 0.2941259092763441 1.551922174116854 0.09505002290481288 0.22993662711449422 1.764294242328277e-07 6.753428983170789 -0.6376856315580481 LQSLK(ub)AER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQSLKAER 8 1 Q96R06;J3KTQ0;J3QS12 Q96R06 SPAG5 Sperm-associated antigen 5 1 6710100.0 1137400.0 2350200.0 3222500.0 True False 1725518.9550781783 1930788.4478035895 2585571.462528075 1.0 1.1189610187250079 1.4984312139364069 20.718598891400752 -6.950063251862442 0.55814684810821 0.9949880684354082 1.6404821200378454 0.9992062506384917 0.005988180201750149 0.0834603213423455 0.035857047672872004 0.006433449276879668 0.03153172118365244 1.1218550522970565e-07 6.950063251862442 0.6454940516024372 LQSLK(ub)AER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQSLKAER 8 1 Q96R06;J3KTQ0;J3QS12 Q96R06 SPAG5 Sperm-associated antigen 5 1 2255250.0 669010.0 646800.0 939440.0 True False 916361.0763154539 618222.2373184252 717563.6203741274 1.0 0.6746491675576195 0.7830577257376969 19.805556653944436 -10.822457124278033 10.365904094746584 1.0039157203298488 0.7288534466476583 0.8929454435450449 0.04425760854866885 0.0040277500637645475 6.898543603124952e-05 0.043095026665178685 0.014284081737663459 1.5050220947719876e-11 10.822457124278033 -0.2750622736821905 LQSLK(ub)AER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQSLKAER 8 1 Q96R06;J3KTQ0;J3QS12 Q96R06 SPAG5 Sperm-associated antigen 5 1 4073110.0 1323700.0 2163300.0 586110.0 True False 1100715.199852851 2151645.873518568 708662.8911335493 1.0 1.9547707470617381 0.6438203917128489 20.07000980215827 -6.711417264871968 1.7902080119821961 1.586119846200214 0.6467760074207004 0.4718173272104337 0.40224671448847227 0.37222803269770666 2.3262976785256444 0.1787522306614099 0.4533265650548508 1.9434919008520581e-07 6.711417264871968 -0.9393438387795136 LQSLK(ub)AER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQSLKAER 8 1 Q96R06;J3KTQ0;J3QS12 Q96R06 SPAG5 Sperm-associated antigen 5 1 4089580.0 1137400.0 2080700.0 871480.0 True False 1472386.7215058748 1964907.215917705 712879.5821399209 1.0 1.33450484659907 0.48416599506604324 20.4897252134932 -6.800037083823185 1.4561829017739127 1.1845525602737945 0.47247266990612186 0.8321504343321937 0.14329902630118 0.2207093325242007 0.92402426082771 0.07742347736810827 0.18002051001231018 1.5847578663353505e-07 6.800037083823185 -0.7120798903676726 down LQSLQSELQFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQSLQSELQFK 11 0 A0A0U1RQR9;A0A0U1RRM7;A0A0U1RQW3;Q8WXE1-5;Q8WXE1-3;Q8WXE1-2;Q8WXE1 A0A0U1RQR9 ATRIP ATR-interacting protein 0 23471800.0 1906400.0 5836400.0 15729000.0 False True 2499308.8616038584 4965631.870109013 14101513.963221876 1.0 1.9868020101054913 5.642165392144707 21.253097768295866 -6.94664106726271 0.5945779996338458 0.9582867980879336 6.856065521984317 0.9989106318637148 0.06590578181292779 0.08486322719514428 0.04176528149312297 0.06800864950528954 0.30665704888400314 1.1307300466484935e-07 6.94664106726271 5.8977787238963835 LQSLQSELQFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQSLQSELQFK 11 0 A0A0U1RQR9;A0A0U1RRM7;A0A0U1RQW3;Q8WXE1-5;Q8WXE1-3;Q8WXE1-2;Q8WXE1 A0A0U1RQR9 ATRIP ATR-interacting protein 0 13629300.0 4071900.0 1684500.0 7872900.0 False True 3942639.7633453724 2357129.6345514497 5810751.308062663 1.0 0.5978556946707705 1.4738225292823046 21.910730467602182 -6.781867200475953 1.5284791992234397 0.772849305550527 1.4811868223529847 0.7739821817662735 0.17020311010194916 0.24768248594759024 1.1430297637152635 0.08769259320964234 0.20660721571203688 1.6524670159886698e-07 6.781867200475953 0.7083375168024577 LQSLQSELQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQSLQSELQFK 11 0 A0A0U1RQR9;A0A0U1RRM7;A0A0U1RQW3;Q8WXE1-5;Q8WXE1-3;Q8WXE1-2;Q8WXE1 A0A0U1RQR9 ATRIP ATR-interacting protein 0 12538500.0 1906400.0 4889300.0 5742800.0 False True 2611247.598522859 4673274.559247024 4386468.916678585 1.0 1.7896711755295134 1.6798364579291294 21.316307829818758 -10.07920495311914 4.328363989071403 0.9999256715548244 1.734753816815276 0.9835169080549687 0.044839836004173655 31394371.10082395 67071326.28444636 34421.1076810077 0.016409691696972657 8.332878449503368e-11 10.07920495311914 0.7348281452604517 LQSNPHLK(ub)EGSVTSVNLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQSNPHLKEGSVTSVNLTK 19 1 Q03154;A0A1B0GV31;A0A1B0GU86;A0A1B0GW23;Q03154-4;C9JMV9;Q03154-2 Q03154 ACY1;ABHD14A-ACY1 Aminoacylase-1 1 113023000.0 13164000.0 11856000.0 88003000.0 True False 19970750.417310648 9740204.16864921 70609168.47691487 1.0 0.48772349386562863 3.5356292077893494 24.25138520846023 -6.8636802411047615 1.1670800520460163 0.7188737447841406 3.6938853351411245 0.9579543303372074 0.27324305300840596 0.14305411553694272 0.3681981047096261 0.18232167393627646 0.4274919775569452 1.3687362169348958e-07 6.8636802411047615 2.975011590356984 up LQSNPHLK(ub)EGSVTSVNLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQSNPHLKEGSVTSVNLTK 19 1 Q03154;A0A1B0GV31;A0A1B0GU86;A0A1B0GW23;Q03154-4;C9JMV9;Q03154-2 Q03154 ACY1;ABHD14A-ACY1 Aminoacylase-1 1 70635000.0 13164000.0 14687000.0 42784000.0 True False 17041057.5012338 13869655.539089398 34997751.00091154 1.0 0.8138964109525018 2.0537311723980536 24.02251153055268 -6.868681784277019 1.1411086988895753 0.8955498064890698 2.1245266044719693 0.9633464887283859 0.10451533683767318 0.13812175126845586 0.3369746532522312 0.0711398314597344 0.1680441363156305 1.3530636151902428e-07 6.868681784277019 1.2289767979828996 up LQSQK(ub)GVQGIIVVNTEGIPIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQSQKGVQGIIVVNTEGIPIK 21 1 Q9NP97;B1AKR6 Q9NP97 DYNLRB1 Dynein light chain roadblock-type 1 1 62743900.0 23701000.0 29183000.0 9859900.0 True False 22948624.728271507 40835924.08733453 7277296.399340408 1.0 1.7794497304680226 0.3171125278969401 24.451904362201244 -6.761900703006008 1.6052847726706843 1.4516735702626573 0.31125546152681594 0.6987006438380328 0.3279339557178972 0.27973075604178915 1.4211311620822498 0.16114842626766807 0.3865465168213374 1.730211909261219e-07 6.761900703006008 -1.1404181087358414 LQSQK(ub)GVQGIIVVNTEGIPIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQSQKGVQGIIVVNTEGIPIK 21 1 Q9NP97;B1AKR6 Q9NP97 DYNLRB1 Dynein light chain roadblock-type 1 1 15384800.0 3939200.0 8789400.0 2656200.0 True False 5395628.69287729 8401055.245341012 2028860.2661561724 1.0 1.5570113741205271 0.3760192521836146 22.363359640112947 -6.778456247225524 1.541944581757194 1.31602674895975 0.3671226748881126 0.7618687322270254 0.23540311947811818 0.2529809581662893 1.1879536876188441 0.12025798750238598 0.28411973861137163 1.6654966089336467e-07 6.778456247225524 -0.9489040740716372 down LQSQK(ub)GVQGIIVVNTEGIPIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQSQKGVQGIIVVNTEGIPIK 21 1 Q9NP97;B1AKR6 Q9NP97 DYNLRB1 Dynein light chain roadblock-type 1 1 63585000.0 23701000.0 33549000.0 6335000.0 True False 19708431.6323279 33368264.87804493 7659619.210269466 1.0 1.6930959043595684 0.38864681640650345 24.23230963763552 -6.762341121314067 1.603522396549496 1.4014109938045993 0.3832979432469912 0.7005122728198256 0.29162521497356453 0.27899699519031884 1.414367846718626 0.1434540916210336 0.34396925979118775 1.7284581896469632e-07 6.762341121314067 -1.0181130505576081 LQSQK(ub)GVQGIIVVNTEGIPIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQSQKGVQGIIVVNTEGIPIK 21 1 Q9NP97;B1AKR6 Q9NP97 DYNLRB1 Dynein light chain roadblock-type 1 1 62039000.0 25738000.0 24223000.0 12078000.0 True False 33318348.371828943 22874968.756271712 9879927.930745354 1.0 0.6865577039110609 0.29653114315531165 24.989813550664405 -7.180437348843869 0.33483991993014484 1.052161292155411 3.0083078855982364e-16 0.9998805660728423 0.0031447676022492007 0.0864653574771064 0.01807401612450927 0.008535781768707437 0.039837286821734604 6.600284428471664e-08 7.180437348843869 -1.0521612921554109 down LQTASDESYKDPTNIQSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQTASDESYKDPTNIQSK 18 1 Q13813;Q13813-3 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 5534900.0 1566500.0 521900.0 3446500.0 False True 1516772.3149587493 730297.3916725462 2543758.257216272 1.0 0.4814812246176893 1.6770864236702876 20.532573105975047 -6.788805062670644 1.5008850696252167 0.7097598782784719 1.6894327265774625 0.7975351849671657 0.2202705331319816 0.23711362559451726 1.0551896239529386 0.11552152125014355 0.27072689821017804 1.626278562999731e-07 6.788805062670644 0.9796728482989906 LQTHCYK(ub)VHDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQTHCYKVHDR 11 1 Q8WV22;I3L1I3;H3BR31;H3BN81;H3BSL0;H3BR73 Q8WV22 NSMCE1 Non-structural maintenance of chromosomes element 1 homolog 1 2421720.0 465120.0 1130300.0 826300.0 True False 450355.0201938156 1581634.6844366312 609867.2415313523 1.0 3.5119730290914846 1.3541921688113718 18.780703217965502 -6.609152899218584 2.1563576396854387 2.6791626818221244 1.3617635666480006 0.04790017921840428 1.0832151221885615 0.6149920372716057 5.417453726373745 0.41495297647652446 1.2030773760989704 2.4595015510742584e-07 6.609152899218584 -1.3173991151741238 LQTHCYK(ub)VHDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQTHCYKVHDR 11 1 Q8WV22;I3L1I3;H3BR31;H3BN81;H3BSL0;H3BR73 Q8WV22 NSMCE1 Non-structural maintenance of chromosomes element 1 homolog 1 3073650.0 580140.0 944410.0 1549100.0 True False 794633.4356940056 902682.8434537632 1183234.4847159588 1.0 1.1359739005512535 1.4890318372804972 19.599929973242983 -6.954645048704274 0.5052857685379102 0.9932419470423871 1.6471289912904448 0.999517177227282 0.004528655365442534 0.08167247088985267 0.028645400769461666 0.005259601307466268 0.029130614798928797 1.1100817205673456e-07 6.954645048704274 0.6538870442480577 LQTHCYK(ub)VHDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQTHCYKVHDR 11 1 Q8WV22;I3L1I3;H3BR31;H3BN81;H3BSL0;H3BR73 Q8WV22 NSMCE1 Non-structural maintenance of chromosomes element 1 homolog 1 2300580.0 465120.0 974960.0 860500.0 True False 386767.8883097057 969707.696965591 1040426.5714975322 1.0 2.5072083962386618 2.6900541718820437 18.56110849339978 -10.468980415393675 0.43153797694153 1.8252820797650527e-21 2.697970197413083 0.9993727146836029 0.018966829628456187 1.9005208789740007 0.20349103536174146 2.162912479181677 0.04292850132274969 3.396405884130008e-11 10.468980415393675 2.697970197413083 LQTK(ub)QAAMER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQTKQAAMER 10 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 6162800.0 1199300.0 1868800.0 3094700.0 True False 1572293.9140377191 1589982.3245253463 2774490.1304585654 1.0 1.0112500661165842 1.7646129045513852 20.584439499827624 -6.910149778778779 0.8947175838148683 0.9767845633761085 1.8622837902701994 0.9909778400674006 0.03398753062706746 0.10431912184846061 0.13823209228504252 0.027846633908709006 0.07694898264551277 1.2298445508640744e-07 6.910149778778779 0.8854992268940909 LQTK(ub)QAAMER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQTKQAAMER 10 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 10057900.0 1719600.0 1817900.0 6520400.0 True False 1665012.23926145 2543796.950223264 4812511.632192938 1.0 1.5277947454317913 2.8903761298040815 20.66710135169993 -6.954769301790267 0.5037730502951246 0.9735817374206752 3.5037368132343047 0.9995243518538882 0.017369642961205495 0.0816253046654684 0.02846011351796965 0.020228430312040767 0.112417581141855 1.1097641679484546e-07 6.954769301790267 2.5301550758136298 LQTK(ub)QAAMER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQTKQAAMER 10 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 10104000.0 1278700.0 2321600.0 6503700.0 True False 1939881.385491883 1907292.3412564066 5218240.844327023 1.0 0.9832004964431302 2.6899793375788636 20.887537010502424 -6.904676547643782 0.9312185185130559 0.9378530958160902 2.887176317031504 0.9887530355911044 0.0849106118969273 0.10804468867762826 0.15863778753301452 0.06773729927533446 0.18076028168219002 1.245441842346831e-07 6.904676547643782 1.9493232212154137 up LQTK(ub)QAAMER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQTKQAAMER 10 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 5183900.0 1199300.0 1877800.0 2106800.0 True False 1642713.6198638615 1794832.5869457924 1609217.2309079976 1.0 1.0926022437766953 0.9796091122939372 20.647649561350516 -6.688912525858007 1.87050033206221 1.0581152190394305 0.9800068887984849 0.36527173485700204 0.03917294807479623 0.41899271953234224 2.8414408200946726 0.016759916307043196 0.04370035555754974 2.0468568662723685e-07 6.688912525858007 -0.07810833024094566 LQTK(ub)QAAMER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQTKQAAMER 10 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 7531800.0 1719600.0 3645100.0 2167100.0 True False 1429923.5911966166 3625463.122804296 2620230.590461709 1.0 2.5354243717109144 1.8324269958152075 20.447506627134207 -10.095664286160979 4.700069558426902 0.9999343183480737 2.1839256837815384 0.7908667431747985 0.2869974769787153 17785484.178444978 38202910.32579431 7510.851990883995 0.09824687633505766 8.022980078725914e-11 10.095664286160979 1.1839913654334646 LQTK(ub)QAAMER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQTKQAAMER 10 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 5794900.0 1278700.0 2282200.0 2234000.0 True False 1655302.3569452814 2155193.563784967 1827434.9227757184 1.0 1.3019938954005914 1.1039885946565635 20.658663332594873 -10.22234645013829 3.7853699449651437 0.9997757272607041 1.2029912449656044 0.5835637098804951 0.0808353259479645 8817786.796896767 4762489.357427771 15789.32452380662 0.027672081772718474 5.993127951612802e-11 10.22234645013829 0.20321551770490032 LQTMK(ub)EELDFQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQTMKEELDFQK 12 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 26824200.0 9320600.0 10528000.0 6975600.0 True False 12219396.860818794 8957263.43782259 6253831.826680051 1.0 0.733036461606697 0.5117954591304595 23.542669740908263 -6.973281753265189 0.16157961391690442 1.2191253037413612 0.019827974629469673 0.9999979764005039 0.00028387857849054707 0.07525146943932125 0.004995818688533448 0.010087022611245186 0.02639605725305961 1.0634528677712993e-07 6.973281753265189 -1.1992973291118916 LQTMK(ub)EELDFQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQTMKEELDFQK 12 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 20438100.0 8119500.0 6446300.0 5872300.0 True False 7861750.916889603 9020341.207010405 4334168.464776182 1.0 1.1473705161062495 0.5512981154700507 22.90641922503979 -6.841287633726857 1.2764398990198358 1.0783862822665726 0.531191659273378 0.9266464596794423 0.06865719623651234 0.16729382476755383 0.5289215643397059 0.04216842936780199 0.09718187250017957 1.4411605531124427e-07 6.841287633726857 -0.5471946229931947 LQTMK(ub)EELDFQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQTMKEELDFQK 12 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 19583000.0 9320600.0 5748600.0 4513800.0 True False 12766677.699744118 5494607.843921925 3447733.4046290684 1.0 0.4303866654385779 0.2700572134517167 23.605879802431154 -13.999999999999998 0.17783138555287328 3.936192526675367 0.13980665238252796 0.9995009142301706 0.006997484705341851 12.177441013963245 0.13366025984763039 12.348592012468885 0.12195093848183405 1.0000000000000041e-14 13.999999999999998 -3.796385874292839 LQTMK(ub)EELDFQK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LQTMKEELDFQK 12 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 27522360.0 11633300.0 11805000.0 4084060.0 True False 9673604.392572457 11741404.12189096 4938018.063440112 1.0 1.2137569043971026 0.5104630976259066 23.205622108498886 -6.825156200568021 1.3493448725322055 1.1146546287473678 0.49333460099417775 0.8958461901131887 0.09500635348668027 0.186867027702398 0.6670753945117387 0.05530709859854557 0.12733784894079492 1.4956976091125568e-07 6.825156200568021 -0.6213200277531901 LQTQASATVAIPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQTQASATVAIPK 13 0 A0A024R4E5;Q00341;Q00341-2;H0Y394;C9JIZ1;C9J5E5;H7C0A4;C9JZI8 A0A024R4E5 HDLBP Vigilin 0 15551600.0 6278500.0 4491200.0 4781900.0 False True 8231174.3010804895 3821130.4665604867 4287114.859223775 1.0 0.46422664941731273 0.5208387895103879 22.972666836847257 -10.533580923703523 6.806911983606163 1.0003392613970092 0.4925327194638503 0.9907523907002501 0.023111809412498643 0.00011906889973847839 8.158739955333154e-06 0.022392238146814094 0.007459304412943924 2.9269754263533927e-11 10.533580923703523 -0.507806541933159 LQTQASATVAIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQTQASATVAIPK 13 0 A0A024R4E5;Q00341;Q00341-2;H0Y394;C9JIZ1;C9J5E5;H7C0A4;C9JZI8 A0A024R4E5 HDLBP Vigilin 0 14427300.0 6278500.0 4300600.0 3848200.0 False True 8599831.12008277 4110585.2718176013 2939334.4161667717 1.0 0.47798441788215473 0.3417897834415244 23.035876898370148 -13.999999999999998 0.1886274935624477 3.7851780552955225 0.24272157210593281 0.9994902212028064 0.006405096515411927 12.328680045356819 0.13772711723507805 12.614972053211403 0.09469522097750499 1.0000000000000041e-14 13.999999999999998 -3.5424564831895897 LQTQASATVAIPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQTQASATVAIPK 13 0 A0A024R4E5;Q00341;Q00341-2;H0Y394;C9JIZ1;C9J5E5;H7C0A4;C9JZI8 A0A024R4E5 HDLBP Vigilin 0 5862000.0 2471800.0 1789400.0 1600800.0 False True 2055411.2193066985 1779760.147031908 1935519.8787370727 1.0 0.8658900614701475 0.9416703871986911 20.97099562732084 -10.175909627729313 4.407137464819496 1.0000167344612791 0.9037802243359346 0.6824977708598234 0.03093718861602419 6.828088183176348e-06 1.2767929308564185e-06 0.029961794224989666 0.0099849346627062 6.66945539367571e-11 10.175909627729313 -0.09623651012534451 LQTQK(ub)ELQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQTQKELQLR 10 1 O60318-2;O60318 O60318-2 MCM3AP Germinal-center associated nuclear protein 1 7934680.0 557030.0 994050.0 6383600.0 True False 539347.3875528064 1390979.3489022676 4711543.656104976 1.0 2.5790045173178475 8.735638226566321 19.040855270354644 -6.945462167430953 0.6066221910321853 0.9315409148593148 10.701866238492334 0.9987953291020435 0.11583186569884654 0.08536071850088012 0.04390953020490417 0.11812001529813149 0.5185345716792333 1.1338036025074066e-07 6.945462167430953 9.770325323633019 LQTQVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQTQVFK 7 0 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 0 6460610.0 2232700.0 622910.0 3605000.0 False True 2161824.1606181916 871641.211432737 2660742.352318196 1.0 0.40319709036070905 1.2307857414070784 21.04381775062018 -6.7132059108972 1.7836433186193763 0.6343070743009362 1.2290416378960551 0.4803522892643989 0.25136750969318444 0.36867998143729647 2.2882829882214843 0.1120645862355819 0.2836096800104065 1.9355040709246855e-07 6.7132059108972 0.5947345635951189 LQTSSVLVSGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQTSSVLVSGLR 12 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 133749000.0 35318000.0 44332000.0 54099000.0 False True 46302240.01999857 37717838.404782504 48501354.43425141 1.0 0.8146007274916214 1.047494773758311 25.464578654404846 -6.694618155980007 1.8498972478233537 0.8842740397486221 1.046740158560705 0.39216724683777315 0.07833880621646434 0.40682011906479876 2.702620832031001 0.03383237480249257 0.08759598119409281 2.0201417489759043e-07 6.694618155980007 0.16246611881208295 LQTSSVLVSGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQTSSVLVSGLR 12 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 105335000.0 28308000.0 12942000.0 64085000.0 False True 27409378.03501578 18109808.091638397 47299215.991209805 1.0 0.660715761901015 1.725658128060569 24.70816625556461 -6.821003882325932 1.367505574368969 0.8173103687011034 1.7494149973144544 0.886679768643933 0.1495302220204083 0.1921809267834264 0.7059079361564166 0.08591986683129199 0.19798230008344475 1.510066655035374e-07 6.821003882325932 0.932104628613351 LQTSSVLVSGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQTSSVLVSGLR 12 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 201475000.0 28723000.0 128230000.0 44522000.0 False True 43574890.93257475 105346354.63443705 35722207.18531416 1.0 2.4175930766515026 0.8197887916825456 25.37699371751877 -6.672654204897976 1.9283146152992705 1.902809937171586 0.8262286329813555 0.29064233024635355 0.6018043281592338 0.4550927780069644 3.265021671685674 0.25104323702471043 0.668326378538959 2.124935710542149e-07 6.672654204897976 -1.0765813041902306 LQTSSVLVSGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQTSSVLVSGLR 12 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 113043000.0 35318000.0 37210000.0 40515000.0 False True 48376019.03306261 35565939.16298484 30946191.432617042 1.0 0.7351977255234105 0.6397010760944768 25.527788715927738 -13.999999999999998 0.14194073899948803 2.2672520308127977 0.5242372702002343 0.999595309930839 0.003065982731675797 11.936488153021578 0.11817741917889787 4.185323847912698 0.10336374548900802 1.0000000000000041e-14 13.999999999999998 -1.7430147606125634 LQTSSVLVSGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQTSSVLVSGLR 12 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 67271000.0 28308000.0 23790000.0 15173000.0 False True 23539356.257032935 23661838.548054725 18345604.147974502 1.0 1.00520329824165 0.7793587873709725 24.488571530998886 -6.901626421350024 0.9509171409754297 1.0089753673249933 0.7548527811828337 0.9873585572286679 0.011834721737196383 0.11021837167751367 0.1707399621548201 0.009304823106298675 0.024413530857956434 1.254219586514141e-07 6.901626421350024 -0.25412258614215955 LQTSSVLVSGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQTSSVLVSGLR 12 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 99395000.0 28723000.0 47459000.0 23213000.0 False True 37182489.714975595 44817864.93018608 18988472.185493637 1.0 1.2053486808909213 0.510683182623079 25.148120039611218 -6.827520127085752 1.3388945028308812 1.1099288026033343 0.4929120136418405 0.9008320256821379 0.09176062939565444 0.18389335087748912 0.6455757460286118 0.05382303379719481 0.12388534376987814 1.4875784316597738e-07 6.827520127085752 -0.6170167889614937 LQTVAEK(ub)EVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQTVAEKEVK 10 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 5546780.0 964880.0 1075600.0 3506300.0 True False 1264967.023911212 915124.6726559609 3143501.7108045616 1.0 0.7234375721719948 2.485046369892725 20.270668345500788 -6.866769459413826 1.151108332694117 0.8462733220051786 2.582047803423756 0.9613479909368705 0.15207655804545167 0.13998676007852845 0.3487147835731058 0.10272221087241169 0.2419151640443017 1.3590346841831868e-07 6.866769459413826 1.7357744814185776 up LQTVAEK(ub)EVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQTVAEKEVK 10 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 7822440.0 964880.0 685360.0 6172200.0 True False 1321622.2109015635 655078.5290175581 4714453.480449191 1.0 0.4956624696634652 3.5671717995970718 20.33387840702368 -6.864752188874723 1.161407232583768 0.7220452063401667 3.7300534068798306 0.959164077369571 0.27177682354745747 0.1419908210762421 0.3612660065408902 0.1821196403220807 0.42768864275672136 1.3653619983816428e-07 6.864752188874723 3.008008200539664 up LQTVAEK(ub)EVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQTVAEKEVK 10 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 9053050.0 977650.0 1957700.0 6117700.0 True False 812959.2922385285 1947153.481526973 7396882.7849511495 1.0 2.39514265980696 9.098712390116635 19.632823587676896 -6.940696830371238 0.6530490345466856 0.9255643231585587 10.944119032710695 0.9982537493037006 0.1477260131602241 0.08745017993302459 0.0531728227910302 0.1445709959423461 0.5752144420945596 1.146312873268492e-07 6.940696830371238 10.018554709552136 LQTVLEAVHDLLRPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQTVLEAVHDLLRPR 15 1 Q9HBI1-3;Q9HBI1;Q9HBI1-2;A0A087WZB5;B0QYP8 Q9HBI1-3 PARVB Beta-parvin 0 16950300.0 2952000.0 1628900.0 12369400.0 False True 3870100.5872086645 1385874.4694024702 11089533.143663106 1.0 0.3580977905284992 2.865437963115451 21.883939633053355 -6.838780334781721 1.287904854538846 0.6584290880501276 2.946004856968776 0.9223541048419422 0.2963351226707208 0.17023292477681787 0.5490014651056544 0.1804483198749927 0.4156249004356393 1.449504824595617e-07 6.838780334781721 2.2875757689186482 up LQTVLEAVHDLLRPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQTVLEAVHDLLRPR 15 1 Q9HBI1-3;Q9HBI1;Q9HBI1-2;A0A087WZB5;B0QYP8 Q9HBI1-3 PARVB Beta-parvin 0 58407400.0 22830000.0 14177400.0 21400000.0 False True 22105274.146510206 19838509.75416428 15794698.013761267 1.0 0.8974559475117939 0.7145216978118681 24.397887290716056 -6.962217685780497 0.4029689554999642 1.0097326759332241 0.5955332537974329 0.9998437974754683 0.0014757180343701534 0.07891831050307295 0.018273133986612046 0.002353358230462667 0.015310261469485942 1.0908933999430433e-07 6.962217685780497 -0.4141994221357912 LQTVLEAVHDLLRPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQTVLEAVHDLLRPR 15 1 Q9HBI1-3;Q9HBI1;Q9HBI1-2;A0A087WZB5;B0QYP8 Q9HBI1-3 PARVB Beta-parvin 0 38664000.0 14394000.0 12389000.0 11881000.0 False True 21836750.342355646 10178086.154301187 9532715.142372705 1.0 0.4660989384743418 0.43654458620990766 24.380254840350474 -13.913098701743083 0.4127739124650262 9.99999999999955 0.43529578664964186 0.9998538158741824 0.0031306380320568973 26.642209827236027 0.2131264996557087 215.1794490671478 0.00730938668122289 1.221522014331001e-14 13.913098701743083 -9.56470421334991 LQTVLEAVHDLLRPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQTVLEAVHDLLRPR 15 1 Q9HBI1-3;Q9HBI1;Q9HBI1-2;A0A087WZB5;B0QYP8 Q9HBI1-3 PARVB Beta-parvin 0 26765800.0 2952000.0 8054400.0 15759400.0 False True 4043434.1748004034 7698529.975660995 12037354.2950311 1.0 1.9039582797316141 2.9770125528568303 21.947149694576247 -6.9688536036375295 0.28423454471446946 0.7753349443855462 4.138524886444318 0.9999720096745088 0.004275296641185561 0.07667644455960539 0.01035524777099559 0.019349462880121078 0.09797738812711021 1.07435150454562e-07 6.9688536036375295 3.363189942058772 LQTVLEAVHDLLRPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQTVLEAVHDLLRPR 15 1 Q9HBI1-3;Q9HBI1;Q9HBI1-2;A0A087WZB5;B0QYP8 Q9HBI1-3 PARVB Beta-parvin 0 49650000.0 22830000.0 12366000.0 14454000.0 False True 18984156.54048546 12299381.90354119 17476264.57225489 1.0 0.6478761317265599 0.9205710316908284 24.178292566150333 -10.410855616330736 5.898753417006434 1.0000722408745968 0.7842235817087155 0.4549873067624469 0.11132722672862731 0.00010580226140018664 1.0567110219310235e-05 0.1078281081570439 0.03593070792495246 3.882794302391532e-11 10.410855616330736 -0.21584865916588125 LQTVLEAVHDLLRPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQTVLEAVHDLLRPR 15 1 Q9HBI1-3;Q9HBI1;Q9HBI1-2;A0A087WZB5;B0QYP8 Q9HBI1-3 PARVB Beta-parvin 0 30494400.0 14394000.0 10172000.0 5928400.0 False True 18633316.748158585 9605919.25809336 4849492.030520851 1.0 0.5155238537466849 0.2602591957226346 24.151381162442924 -9.28853235938218 0.19664029653741016 1.4600624016397916 3.8391594876370436e-21 0.9995498844730231 0.006508880259130114 0.7146045278556236 0.07228793232728338 0.34471336546094294 0.14415192204439656 5.145974628093886e-10 9.28853235938218 -1.4600624016397916 LQTYK(ub)TAVETAVLLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQTYKTAVETAVLLLR 16 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 17877200.0 3550900.0 9546800.0 4779500.0 True False 4655264.2869645115 8122454.653134934 4284963.188201352 1.0 1.7447891574876022 0.9204554079131314 22.150431643589396 -6.668758040039573 1.9419757919465812 1.4759130568386132 0.9238216798216498 0.27344365896304046 0.3164630755259088 0.46399306898948695 3.3723943827988476 0.13125320732747944 0.3512189748285294 2.1440848096780075e-07 6.668758040039573 -0.5520913770169634 LQTYK(ub)TAVETAVLLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQTYKTAVETAVLLLR 16 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 88398000.0 30083000.0 32501000.0 25814000.0 True False 29128031.63160168 45478818.79047599 19052538.996599693 1.0 1.5613419871851195 0.6540963439468787 24.79590487680291 -6.739379669791948 1.689423330685669 1.3342415430637182 0.653682910251503 0.6019843706818769 0.23585388384002473 0.31892736380112885 1.7871603102083822 0.11046402583413638 0.27120584884467314 1.8223019093310863e-07 6.739379669791948 -0.6805586328122152 LQTYK(ub)TAVETAVLLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQTYKTAVETAVLLLR 16 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 115373000.0 34355000.0 33994000.0 47024000.0 True False 52119046.68692703 27927505.103665706 37729685.788648665 1.0 0.535840673975158 0.7239135822127838 25.63530735992455 -10.175530280272538 5.359863443422779 1.000014102652749 0.6298771280938769 0.8377651379871567 0.0767804432709079 1.2939647517983467e-05 1.9904992059898747e-06 0.07434517490612214 0.024780781508506426 6.675283573260661e-11 10.175530280272538 -0.37013697455887207 LQTYK(ub)TAVETAVLLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQTYKTAVETAVLLLR 16 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 25104400.0 3550900.0 8840500.0 12713000.0 True False 4863763.689464344 8449897.478375914 9710451.232453655 1.0 1.7373166168989016 1.9964891085247374 22.213641705112288 -10.676535469880983 0.2159961519797708 6.010460164269017e-14 2.1778103206320485 0.9993046753459542 0.011131332643988443 2.4817362668327503 0.1125399637189273 1.4410757516955874 0.14402820366511512 2.1060298874112217e-11 10.676535469880983 2.1778103206319885 LQTYK(ub)TAVETAVLLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQTYKTAVETAVLLLR 16 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 61269000.0 30083000.0 20482000.0 10704000.0 True False 25015347.402865697 20371659.40064131 12942156.91029588 1.0 0.8143664396324787 0.5173686657980715 24.576310152237188 -6.964163627347609 0.37213115736022073 1.022294609509356 0.299067804204365 0.999894846971179 0.0020383045726455546 0.07824596525556403 0.01586799190933095 0.0039024328102483475 0.02519529955773523 1.0860163725992865e-07 6.964163627347609 -0.7232268053049908 LQTYK(ub)TAVETAVLLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQTYKTAVETAVLLLR 16 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 104046000.0 34355000.0 39371000.0 30320000.0 True False 44473224.73829287 37179969.240109555 24802071.10947174 1.0 0.8360079454300603 0.5576854670517373 25.406433682017 -6.963123983682529 0.3889088176174164 1.0173027454817734 0.36640773008152716 0.9998690963507664 0.002088876793132434 0.0786034708135285 0.017141492225821613 0.0035957605047765365 0.023422907546201393 1.0886192666962543e-07 6.963123983682529 -0.6508950154002462 LQVELDNVTGLLSQSDSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQVELDNVTGLLSQSDSK 18 0 P35579 P35579 MYH9 Myosin-9 0 12375100.0 5631300.0 5348400.0 1395400.0 False True 7382688.83358678 4550439.567899908 1251017.3936219595 1.0 0.6163661601445469 0.16945281344252044 22.81571492224725 -7.553885450086351 0.4171617202930225 1.0343525198862404 8.133774496713553e-19 0.9984981177097799 0.013153046696447531 0.1198718467674278 0.05597611971195715 0.021582869594096523 0.06959383992933642 2.7932805023269544e-08 7.553885450086351 -1.0343525198862404 down LQVELDNVTGLLSQSDSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQVELDNVTGLLSQSDSK 18 0 P35579 P35579 MYH9 Myosin-9 0 36196000.0 13500000.0 10866000.0 11830000.0 False True 13071449.889526404 15204850.465441408 8731368.107607279 1.0 1.1632107068416646 0.6679724270375968 23.63991583842955 -6.817901642060507 1.3809099206013404 1.088160624587813 0.6576380655914276 0.8794941865955095 0.07153104338790094 0.19622159298576408 0.7357958723543192 0.040711398911657155 0.0938906466691503 1.5208919385730197e-07 6.817901642060507 -0.4305225589963855 LQVELDNVTGLLSQSDSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQVELDNVTGLLSQSDSK 18 0 P35579 P35579 MYH9 Myosin-9 0 70489000.0 11489000.0 59000000.0 0.0 False True 17429652.958407953 48470989.03089601 0.0 1.0 2.7809497496342237 0.0 24.05504050847902 -6.733719979962797 1.70946160999334 2.067293393760136 0.00043511332819964416 0.5765004382999517 0.7484768669092704 0.329314853434788 1.8869020776380523 0.3467249311567239 0.856842080072316 1.846205413298783e-07 6.733719979962797 -2.066858280431936 LQVELDNVTGLLSQSDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQVELDNVTGLLSQSDSK 18 0 P35579 P35579 MYH9 Myosin-9 0 12424800.0 5631300.0 2240900.0 4552600.0 False True 7713343.790160412 2141889.6283346647 3477369.6437401497 1.0 0.2776862650757228 0.45082518533351046 22.87892498377014 -10.593553710654218 9.718514375715253 1.000071322794651 0.3642557252153176 0.9473042895458565 0.0706836682080009 0.0001092438508183303 4.568777064653703e-06 0.06844667038131708 0.022813055818203195 2.549448769427046e-11 10.593553710654218 -0.6358155975793334 LQVELDNVTGLLSQSDSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQVELDNVTGLLSQSDSK 18 0 P35579 P35579 MYH9 Myosin-9 0 40910000.0 13500000.0 10691000.0 16719000.0 False True 11225848.15140402 10633405.461002652 20214865.600078158 1.0 0.9472251287910686 1.8007428327408723 23.420321113863825 -6.8921763589065765 1.009384697209035 0.9565036125402882 1.8773713518215163 0.9822562794480189 0.05201780255656518 0.11739646969315443 0.2116587140116198 0.03914880149816958 0.09839855373891467 1.2818099577866644e-07 6.8921763589065765 0.9208677392812281 LQVIVCSATLHSFDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQVIVCSATLHSFDVK 16 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 23002800.0 9226700.0 6196400.0 7579700.0 False True 8933803.458940227 8670654.83379913 5594349.18387413 1.0 0.9705446144690189 0.6262001631875793 23.090843085446064 -6.9237746632266015 0.7962330936821003 1.0066147609679 0.5655466313653702 0.9951667571227637 0.011797442971837924 0.09600152696609816 0.09447711930908329 0.010373453038999133 0.032289113042308755 1.1918602527719621e-07 6.9237746632266015 -0.4410681296025297 LQVIVCSATLHSFDVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQVIVCSATLHSFDVK 16 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 125486000.0 33935000.0 44315000.0 47236000.0 False True 51481875.98081421 36406642.01532469 37899783.89572569 1.0 0.707173958246828 0.7361772113714316 25.617561290009963 -9.965432035686613 5.647753622933985 1.000000399545508 0.7216755850334259 0.9919215229438855 0.01184052850691208 5.95712570396678e-08 1.0904546677974836e-08 0.011464558914272978 0.003821514142999167 1.0828491608478977e-10 9.965432035686613 -0.27832481451208213 LQVIVCSATLHSFDVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQVIVCSATLHSFDVK 16 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 22012900.0 3423700.0 6318200.0 12271000.0 False True 4689534.412013599 6039041.03250662 9372842.529177912 1.0 1.2877698513174078 1.9986722999977704 22.161013265023882 -6.955716733336021 0.4921029029642865 0.9847348546513447 2.3319603552241457 0.9995768752945893 0.008633789598492977 0.08126823149137481 0.0270667820118041 0.010282193726592765 0.05863351438065616 1.1073458099127304e-07 6.955716733336021 1.3472255005728009 LQVIVCSATLHSFDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQVIVCSATLHSFDVK 16 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 20333700.0 9226700.0 3433400.0 7673600.0 False True 7672409.8621155005 3414903.5927234623 9278114.28128236 1.0 0.4450887861955118 1.2092829303991486 22.87124836088034 -6.711975566164026 1.7884542565863428 0.6595428123635312 1.2075731476382239 0.47439901410917107 0.2337649723836583 0.3710917272340044 2.315043430295209 0.10397579875542068 0.263487737653329 1.9409950768186942e-07 6.711975566164026 0.5480303352746927 LQVIVCSATLHSFDVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQVIVCSATLHSFDVK 16 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 113123000.0 33935000.0 49482000.0 29706000.0 False True 43929526.45885524 46728283.201826215 24299812.80929969 1.0 1.0637101505201134 0.5531544445865834 25.388687612102412 -6.875632819718159 1.103927678412447 1.037601355079622 0.5198787119278672 0.9699858745505727 0.03935376785889252 0.1315658273751267 0.2962971982763303 0.02756162202873847 0.06596823768501012 1.3315797447283025e-07 6.875632819718159 -0.5177226431517548 LQVK(ub)EHQHEEIQNVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQVKEHQHEEIQNVR 15 1 F5H6I7;Q6DD88 F5H6I7 ATL3 Atlastin-3 1 4604930.0 947730.0 1110100.0 2547100.0 True False 1242483.2078303758 944477.4071359092 2283550.5255084564 1.0 0.7601530557383996 1.837892464958132 20.244794923209483 -6.84830584151828 1.2432162015896817 0.8721701145989139 1.8795940803614704 0.9378078719017273 0.11521867084076934 0.1593293685770498 0.47473262099730207 0.07255068067497115 0.1677172958087318 1.4180585361125417e-07 6.84830584151828 1.0074239657625563 LQVK(ub)EHQHEEIQNVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQVKEHQHEEIQNVR 15 1 F5H6I7;Q6DD88 F5H6I7 ATL3 Atlastin-3 1 4938880.0 756580.0 1623300.0 2559000.0 True False 629129.7921769812 1614554.960700179 3094075.0685208454 1.0 2.5663304786653414 4.9180234460275685 19.26299815642763 -6.965241671343894 0.353879952420365 0.7826461869551743 6.7815375280954555 0.9999180411338093 0.014577341878942838 0.07787904778034775 0.01457130169570126 0.031976157215311066 0.201625101960984 1.0833239102673331e-07 6.965241671343894 5.998891341140281 LQVLLTYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQVLLTYR 8 0 A6NKB8;Q9H4A4;A0A087WU27;A0A087WUS4 A6NKB8 RNPEP Aminopeptidase B 0 19141100.0 10125000.0 4960100.0 4056000.0 False True 9803587.41714479 6940693.796579787 2993611.9226082116 1.0 0.7079748974790295 0.3053588237886163 23.224878339150703 -7.07457665187017 0.3484995889185423 1.042684354849818 2.7726132359622233e-12 0.9999192251767643 0.002559462298679344 0.07424913390055053 0.014945159955480996 0.006164722374689683 0.03374044594693074 8.422157293879295e-08 7.07457665187017 -1.0426843548470452 down LQVLLTYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQVLLTYR 8 0 A6NKB8;Q9H4A4;A0A087WU27;A0A087WUS4 A6NKB8 RNPEP Aminopeptidase B 0 223312000.0 64861000.0 68702000.0 89749000.0 False True 98398878.97426216 56441591.328823924 72010070.81161588 1.0 0.5735999425723859 0.7318179999840374 26.55213854372437 -10.041502421509547 5.759578362398212 1.0000010474942584 0.6527089712781418 0.8653039340163615 0.0645922514590675 8.688314697824519e-07 1.4449391877006139e-07 0.06254136771969211 0.020847059516214773 9.088612314850038e-11 10.041502421509547 -0.3472920762161167 LQVLLTYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQVLLTYR 8 0 A6NKB8;Q9H4A4;A0A087WU27;A0A087WUS4 A6NKB8 RNPEP Aminopeptidase B 0 25087900.0 10125000.0 7052200.0 7910700.0 False True 8419386.113553002 7014208.398847904 9564790.795055816 1.0 0.8331021174521108 1.1360437288484742 23.00528361458498 -6.757151432856352 1.6233201635406467 0.9027131554650285 1.1369924906336097 0.6791824409453489 0.07017168520776941 0.2877291473179729 1.493711717599274 0.034118571623641666 0.08222043425513444 1.7492366461296374e-07 6.757151432856352 0.23427933516858124 LQVLLTYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQVLLTYR 8 0 A6NKB8;Q9H4A4;A0A087WU27;A0A087WUS4 A6NKB8 RNPEP Aminopeptidase B 0 189851000.0 64861000.0 72751000.0 52239000.0 False True 83963843.10145296 68702342.8967313 42732038.01740411 1.0 0.8182372359221184 0.5089338033964366 26.32326486581682 -6.963076313810297 0.3896608604118831 1.0190682157298485 0.2969952899699002 0.9998678331313654 0.002330520297695701 0.078619967142538 0.01720050116058862 0.00399422794280034 0.0260218028726909 1.088738764391212e-07 6.963076313810297 -0.7220729257599483 LQVLVGDVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LQVLVGDVLK 10 0 Q9UNQ2;A0A494C0G7;A0A0C4DGB1;D6RCL3 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 0 21907700.0 4220500.0 9883500.0 7803700.0 False True 6402807.059879958 8119712.204862034 6261295.274516785 1.0 1.2681488179989395 0.9778984773334984 22.61027310623611 -6.663916239634558 1.9588247307805355 1.1720444479358683 0.9790948045032382 0.25242145294520013 0.11406569946080553 0.475249139213213 3.5094005518204985 0.04697791326237161 0.12652268927796692 2.1681222201901214e-07 6.663916239634558 -0.1929496434326301 LQVLVGDVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LQVLVGDVLK 10 0 Q9UNQ2;A0A494C0G7;A0A0C4DGB1;D6RCL3 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 0 12300700.0 4220500.0 8080200.0 0.0 False True 5463520.448492663 7630529.766933357 0.0 1.0 1.3966324165655046 0.0 22.38139942832856 -6.858539170706774 1.3868169709315754 1.2096634464639329 1.5352553736598014e-22 0.9066124913926185 0.17957944076526683 0.16675364167502885 0.6447192940814315 0.10436797309600171 0.21816823199997987 1.3850352585791783e-07 6.858539170706774 -1.2096634464639329 down LQVMANSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQVMANSR 8 0 Q15046;Q15046-2;H3BVA8 Q15046 KARS Lysine--tRNA ligase 0 6289400.0 0.0 2945400.0 3344000.0 False True 0.0 2505957.801079274 2997994.957913028 0.0 LQVMANSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQVMANSR 8 0 Q15046;Q15046-2;H3BVA8 Q15046 KARS Lysine--tRNA ligase 0 2995000.0 0.0 0.0 2995000.0 False True 0.0 0.0 2287642.683961201 0.0 LQVSYDCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQVSYDCR 8 0 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 0 4264600.0 1268600.0 1408800.0 1587200.0 False True 1663146.8851398774 1198612.531459388 1422971.7694974751 1.0 0.720689520672481 0.8555899555304746 20.66548415893847 -10.096665902018643 4.726991986777913 1.0000113761782299 0.7881397380983842 0.7668236677401822 0.05507287192422632 6.6030262033474e-06 1.261867615114487e-06 0.05332694113559463 0.017774692981023486 8.004497954603044e-11 10.096665902018643 -0.21187163807984566 LQVSYDCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQVSYDCR 8 0 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 0 3996800.0 1268600.0 1118700.0 1609500.0 False True 1737635.702625948 1069272.1349538087 1229369.248693005 1.0 0.6153603619780051 0.7074953897615932 20.72869422046136 -9.779496800737574 5.995627066233706 1.0000000162918041 0.6614278758689702 0.9473820904545924 0.037613967587450906 8.212968226965205e-09 1.629269132863058e-09 0.03641956913952484 0.012139855837148389 1.6615109173646499e-10 9.779496800737574 -0.3385721404228339 LQVTMPGIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQVTMPGIK 9 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 12386100.0 3148400.0 3473900.0 5763800.0 False True 4127582.8891489743 2955607.661156145 5167417.26627366 1.0 0.716062582032249 1.2519233180897014 21.976865756616174 -6.762736927532051 1.6020214754847764 0.8356346201136412 1.2541599579407017 0.7020795306495402 0.11947710226342408 0.27835178510433345 1.4085365708249629 0.05882467013591706 0.1409938689063352 1.7268836293663853e-07 6.762736927532051 0.4185253378270605 LQVTMPGIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQVTMPGIK 9 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 14466400.0 3148400.0 5283600.0 6034400.0 False True 4312448.562310841 5050153.081471299 4609199.002369107 1.0 1.1710639578655417 1.0688125170122031 22.040075818139066 -10.136524382667739 4.703058587265427 0.9999895772780744 1.1199382374401505 0.6472027590101559 0.041743975930224726 4.562411678867942e-06 8.376688941864881e-07 0.04042194258725161 0.013472810297899708 7.302568127920533e-11 10.136524382667739 0.11994866016207617 LQVTNVLSQPLTQATVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQVTNVLSQPLTQATVK 17 0 P04844;P04844-2;Q5JYR4;Q5JYR7 P04844;Q5JYR7 RPN2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 0 15910600.0 3494600.0 6517000.0 5899000.0 False True 4581454.441754541 5544689.00306703 5288628.067203629 1.0 1.2102464563510102 1.1543557039450258 22.127374242494117 -10.149428960932623 4.572179860718891 0.9999765341273348 1.1823010801202154 0.9341466630028951 0.022817304133594604 5.476106424207374e-06 1.0187364823156647e-06 0.022095611294034676 0.0073642532413310145 7.088772504994444e-11 10.149428960932623 0.18232454599288062 LQVTNVLSQPLTQATVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQVTNVLSQPLTQATVK 17 0 P04844;P04844-2;Q5JYR4;Q5JYR7 P04844;Q5JYR7 RPN2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 0 10540600.0 3494600.0 3590600.0 3455400.0 False True 4786648.058014057 3431955.419473619 2639305.6861968352 1.0 0.7169851173260294 0.5513891253771983 22.19058430401701 -11.123006856398517 0.08289555113616685 2.0234527054417057 6.545202839159586e-15 0.9999409221948773 0.0014236581680544703 3.6150544183297098 0.052188521955198575 1.0565770767971117 0.3583077252988405 7.533436702710746e-12 11.123006856398517 -2.023452705441699 LQVVAK(ub)DIADTYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQVVAKDIADTYK 13 1 Q3SXM5 Q3SXM5 HSDL1 Inactive hydroxysteroid dehydrogenase-like protein 1 1 6031800.0 1887800.0 2019100.0 2124900.0 True False 2474924.081481207 1717858.1503901575 1905035.7314800818 1.0 0.6941053922599693 0.7697350176252457 21.238952840395033 -10.060198358067218 5.4626220760470305 1.0000019700755745 0.7319202049424346 0.9436703171766047 0.03087566526440621 7.408287956427206e-07 1.27463629383979e-07 0.029895453943671366 0.009965078114254998 8.705658800748039e-11 10.060198358067218 -0.26808176513313986 LQVVLNESNADTYAGRPLPSKAIK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQVVLNESNADTYAGRPLPSKAIK 24 2 A6NHR9-2;A6NHR9;J3KTL8;J3QSH1 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 1 23634800.0 5473100.0 10816000.0 7345700.0 True False 7175287.101575792 9202294.96043778 6585637.428929938 1.0 1.2824985021737778 0.9178221492326964 22.77460512818329 -6.699892628667673 1.8312350595624776 1.1754390769314342 0.9189087721705348 0.4170648506766258 0.11924853722543681 0.39575199399213945 2.5800414659270543 0.051952023915048585 0.13362548279941242 1.995755667905466e-07 6.699892628667673 -0.25653030476089944 LQVVLNESNADTYAGRPLPSKAIK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQVVLNESNADTYAGRPLPSKAIK 24 2 A6NHR9-2;A6NHR9;J3KTL8;J3QSH1 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 1 59640000.0 15306000.0 17780000.0 26554000.0 True False 14820119.408080818 24879646.721475117 19598710.797075544 1.0 1.6787750514283468 1.3224394660672674 23.82105373592762 -10.060444239588401 4.349332848563888 0.9999611007442232 1.500607258549885 0.724636865762186 0.14547339378358495 18897126.63550187 10927740.739860069 6794.259464912495 0.0497994121286911 8.700731372749092e-11 10.060444239588401 0.5006461578056619 LQVVLNESNADTYAGRPLPSKAIK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQVVLNESNADTYAGRPLPSKAIK 24 2 A6NHR9-2;A6NHR9;J3KTL8;J3QSH1 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 1 35140400.0 5473100.0 9738300.0 19929000.0 True False 7496652.974966153 9308029.705748344 15222180.650638629 1.0 1.2416247273057708 2.0305302514963164 22.83781518970618 -6.9495338018329615 0.5639393455651359 0.9898870765223977 2.320226746444467 0.999164182648434 0.012721888009863437 0.08367350972658874 0.03674141017541922 0.013573153608184556 0.06563702174809524 1.123223543990256e-07 6.9495338018329615 1.3303396699220693 up LQVVLNESNADTYAGRPLPSKAIK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQVVLNESNADTYAGRPLPSKAIK 24 2 A6NHR9-2;A6NHR9;J3KTL8;J3QSH1 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 1 54616000.0 15306000.0 23929000.0 15381000.0 True False 12727617.170769615 23800089.72746536 18597095.98629116 1.0 1.869956442603012 1.461160854916461 23.601459011361897 -10.194118547147347 4.645587776369003 0.9998799496677623 1.6655586487647425 0.7794570457981325 0.1668900998396316 117252480.42676358 33.382722069844576 150581.63796705683 0.05713092018892168 6.395602341620008e-11 10.194118547147347 0.6656786990969802 LQWDLGLGHLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQWDLGLGHLPR 12 0 Q5JTH9-2;Q5JTH9-3;Q5JTH9 Q5JTH9-2 RRP12 RRP12-like protein 0 6581300.0 1582800.0 2264800.0 2733700.0 False True 2075066.1278570031 1926900.668121254 2450842.947502048 1.0 0.9285972346872796 1.181091491302556 20.984725882078298 -6.83118284703452 1.3227531961578398 0.9618784159076833 1.188044947915167 0.9081947737583862 0.03220010075686752 0.17935674511258962 0.6133459067175321 0.019111679237798777 0.0439772473557046 1.475085360820529e-07 6.83118284703452 0.2261665320074836 LQWDLGLGHLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQWDLGLGHLPR 12 0 Q5JTH9-2;Q5JTH9-3;Q5JTH9 Q5JTH9-2 RRP12 RRP12-like protein 0 4129700.0 1669500.0 1009300.0 1450900.0 False True 1616502.636338098 1412318.7534299672 1070865.7639330016 1.0 0.8736878750964036 0.6624584085794375 20.624444429667108 -6.963387720716557 0.38472325004875524 1.0137605175675621 0.5148598447992146 0.9998759505043063 0.0015508850952985597 0.07851244314028273 0.016816160262239536 0.0027370647407793203 0.01780943168015706 1.0879583739868558e-07 6.963387720716557 -0.4989006727683475 LQWDLGLGHLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQWDLGLGHLPR 12 0 Q5JTH9-2;Q5JTH9-3;Q5JTH9 Q5JTH9-2 RRP12 RRP12-like protein 0 7572400.0 1582800.0 2258300.0 3731300.0 False True 2168003.9335616794 2158520.838800555 2850043.7885356983 1.0 0.9956258867364944 1.3145934582570327 21.04793594360119 -6.9037909113886125 0.9369760468238333 0.988082067077911 1.3507779713266002 0.9883600138309325 0.016112371139663167 0.10866927841654583 0.16209492248914997 0.012799126991971508 0.033982003349655 1.24798420453822e-07 6.9037909113886125 0.36269590424868914 LQWQTTLGHAVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQWQTTLGHAVLK 13 0 A0A0A0MR50;Q13619-2;Q13619 A0A0A0MR50 CUL4A Cullin-4A 0 7374100.0 2381100.0 2013700.0 2979300.0 False True 3121645.1586052007 1713263.809341121 2671030.615463601 1.0 0.5488336189071001 0.8556483776192739 21.5738751229708 -10.002018245473174 5.567515773596977 1.0000008271527892 0.7022409982629408 0.556695767674503 0.1252566007341956 1.2860226407420496e-06 2.3046536679961665e-07 0.12127951828709245 0.04042639405371486 9.953635995018874e-11 10.002018245473174 -0.2977598288898483 LQWQTTLGHAVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LQWQTTLGHAVLK 13 0 A0A0A0MR50;Q13619-2;Q13619 A0A0A0MR50 CUL4A Cullin-4A 0 6281800.0 2381100.0 1183300.0 2717400.0 False True 3261457.016808009 1131017.8933501758 2075606.0866097375 1.0 0.34678301370260095 0.6364045504549176 21.637085184493692 -10.45451404352597 6.146418099386907 1.0002256451990152 0.4915937820788783 0.8042534206702455 0.11823749726065033 0.0003657578133023263 3.246028058831159e-05 0.11453259869595371 0.038160988148978586 3.5114456957668453e-11 10.45451404352597 -0.508631863120137 LQYEGIFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQYEGIFIK 9 0 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 15841900.0 5477300.0 4723900.0 5640700.0 False True 7180793.342248645 4019112.5336179817 5057054.473415072 1.0 0.5597031333531468 0.7042473209278391 22.775711812773597 -10.374345791822513 5.011022418532933 1.000269593731493 0.6319752271404382 0.8963036241357656 0.059009917474046276 0.00017785928466537303 2.2206663839301543e-05 0.05717740105335077 0.019045368969810707 4.223322130760293e-11 10.374345791822513 -0.36829436659105474 LQYEGIFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LQYEGIFIK 9 0 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 10161600.0 3645400.0 1481500.0 5034700.0 False True 3529678.772391075 2073070.6759204394 3715961.032237567 1.0 0.587325592384176 1.0527759810052915 21.751105462575378 -6.6727684019947695 1.927845719550936 0.7372189218021389 1.0509080532029031 0.29128830870017086 0.17518430862981582 0.45476428034344135 3.2611659901412025 0.07309254282826326 0.19456237472028795 2.1243770352695338e-07 6.6727684019947695 0.31368913140076427 LQYEGIFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LQYEGIFIK 9 0 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 7177300.0 3645400.0 1637300.0 1894600.0 False True 3031311.6186020863 1628479.5399213964 2290752.100359357 1.0 0.5372194432033955 0.75569667146783 21.531510738009654 -10.038010718328314 4.990145404844861 1.0000055972476083 0.6464580573327978 0.7773557244776524 0.0891929549539975 123409896.93635473 0.09840768418307516 7937.027292534288 0.030533120872798594 9.161978782048584e-11 10.038010718328314 -0.35354753991481047 LQYLIDLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LQYLIDLGR 9 0 Q9P015;E5RHF4;E5RIZ4 Q9P015 MRPL15 39S ribosomal protein L15, mitochondrial 0 5357700.0 1653300.0 1766700.0 1937700.0 False True 2167492.3105799737 1503115.2465426612 1737205.3917308806 1.0 0.6934812359913103 0.8014816861177433 21.047595444659258 -10.331158407228893 4.844908622552617 1.0001451499424336 0.7474814610543749 0.8793596960262798 0.044090999133967836 6.916757248674312e-05 9.548561159196155e-06 0.04271535198055533 0.014230308780217351 4.6648919915249736e-11 10.331158407228893 -0.2526636888880588 LRAPIICVLGHVDTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LRAPIICVLGHVDTGK 16 1 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 7427800.0 1209400.0 2678900.0 3539500.0 False True 1656547.8628061018 2560537.3400623556 2703542.9982907046 1.0 1.54570682655975 1.6320343402037596 20.659748457280042 -11.593138953676684 0.3127015839680172 2.5092598781609864e-13 1.6529889526396773 0.9994286540035772 0.006688599287818249 4.12979201691375 0.16608619611474118 2.7923081853716845 0.029540428761665898 2.551884689723371e-12 11.593138953676684 1.6529889526394264 LRECLPLIIFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LRECLPLIIFLR 12 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 67599000.0 13401000.0 21501000.0 32697000.0 False True 20330296.744331505 17663978.561920248 26234423.618395768 1.0 0.8688500115890005 1.290410265443393 24.277127937360294 -6.8231212928541485 1.358173269393277 0.9295212651161396 1.3002538913879624 0.8914219540041404 0.05804268619755105 0.18947096084038678 0.6858667636842238 0.03357375604787844 0.07733074527317589 1.5027222165206472e-07 6.8231212928541485 0.3707326262718228 LRECLPLIIFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LRECLPLIIFLR 12 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 18782600.0 1443600.0 9086400.0 8252600.0 False True 1977337.931823124 8684932.80329336 6303505.847632122 1.0 4.392234965768229 3.1878748423241094 20.91512802152572 -10.033284247222943 9.756821687628568 0.999999998990538 3.790054904046338 0.8773862132673929 0.4916779614989089 1.2726702323079712e-08 0.0 0.4760651426925828 0.1586883797152071 9.26223408563723e-11 10.033284247222943 2.7900549050557997 LRECLPLIIFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LRECLPLIIFLR 12 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 48127000.0 13401000.0 18545000.0 16181000.0 False True 17347858.67320223 17512954.447634812 13236224.031080531 1.0 1.0095167811510715 0.7629889244790155 24.048254259452744 -6.8979215605398885 0.9743308092480036 1.010842410770412 0.7381782160568874 0.9855030741879655 0.013730467114808248 0.11295082778360839 0.18618116817438132 0.01060934891429708 0.02732633955156215 1.2649647965992354e-07 6.8979215605398885 -0.27266419471352454 LREEEVDADAADAAAAEEEDGEFLGMK(ub)GFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LREEEVDADAADAAAAEEEDGEFLGMKGFK 30 2 D6RFI3;E7EQR8;Q9GZM5;D6RGY8 D6RFI3 YIPF3 Protein YIPF3;Protein YIPF3, 36 kDa form III 1 26693900.0 3008300.0 3082600.0 20603000.0 True False 2912803.163160169 4313498.255546636 15206456.223248757 1.0 1.480875299128287 5.22055743950474 21.47397678191555 -6.930626453887938 0.7416327483032029 0.9444318941164168 6.0006856021651895 0.9966599168637177 0.10902671530906996 0.09231390890842225 0.07609642253343737 0.09970113447147733 0.33721881566283507 1.1732040299543298e-07 6.930626453887938 5.056253708048772 up LREEEVDADAADAAAAEEEDGEFLGMK(ub)GFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LREEEVDADAADAAAAEEEDGEFLGMKGFK 30 2 D6RFI3;E7EQR8;Q9GZM5;D6RGY8 D6RFI3 YIPF3 Protein YIPF3;Protein YIPF3, 36 kDa form III 1 26330000.0 3008300.0 5082700.0 18239000.0 True False 2501534.740286571 5055318.486263042 22052690.57239219 1.0 2.020886779962894 8.815664326878737 21.254382057349826 -6.933681729654191 0.715926246680064 0.9094422069111889 10.35106990474964 0.9972136315722154 0.18310654308406057 0.09077084037652393 0.06864199696005874 0.1706348620537948 0.6028495062979455 1.1649794655108865e-07 6.933681729654191 9.44162769783845 LRHEILLSQSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LRHEILLSQSVR 12 1 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 6715800.0 2005700.0 2337700.0 2372400.0 False True 2629492.123226427 1988924.2722832288 2126926.805667725 1.0 0.7563910363963321 0.8088736174109369 21.32635274448498 -10.743506127803537 6.895347313089369 1.0037032294671224 0.7826323269036368 0.9581093748422973 0.0214259239783436 0.0012362910796003283 4.5987622213351506e-05 0.02102653636976039 0.006915187228769245 1.8050692678052492e-11 10.743506127803537 -0.2210709025634856 LRHEILLSQSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LRHEILLSQSVR 12 1 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 4503500.0 2005700.0 1052600.0 1445200.0 False True 2747261.492004459 1006092.6515172765 1103873.52482829 1.0 0.3662165594521585 0.401808684044445 21.38956280600787 -9.998745708873974 5.58358899489276 1.000001581172862 0.38401262174780865 0.9975023048011215 0.014530424020516866 2.8601377594760306e-07 5.12889159440147e-08 0.014069058613380639 0.004689674186813503 1.0028922866626156e-10 9.998745708873974 -0.6159889594250534 LRLEVNLQAMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LRLEVNLQAMK 11 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 48202100.0 15442100.0 11157000.0 21603000.0 False True 23426794.668729357 9165946.179961115 17333157.58106874 1.0 0.39125908215672534 0.7398860077177118 24.48165623762423 -10.2708052396397 5.845835014608354 1.0000237227483284 0.5655725449372744 0.6743080965835276 0.1423263463699546 4.4006965887970204e-05 5.4894117102179295e-06 0.1378144032760011 0.04593563076811382 5.360369906429314e-11 10.2708052396397 -0.434451177811054 LRLEVNLQAMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LRLEVNLQAMK 11 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 47987200.0 15442100.0 19015000.0 13530100.0 False True 19990102.85929831 17956798.53447165 11067760.63054958 1.0 0.8982844491027279 0.5536620150706958 24.252782559716678 -6.948688567579981 0.5730598637409021 1.0042356661975236 0.43086720696740594 0.9990943122593322 0.005748068189964884 0.08401664900463059 0.03817492467964084 0.00606868711628241 0.028735749683827243 1.1254117170206932e-07 6.948688567579981 -0.5733684592301176 LRPLFEACGEVVQIRPIFSNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LRPLFEACGEVVQIRPIFSNR 21 2 A0A499FI31;Q15020-4;Q15020 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 4162490.0 944390.0 1822200.0 1395900.0 False True 1238104.4354857702 1550334.862879968 1251465.6584183008 1.0 1.2521842410423918 1.010791676816252 20.239701581939926 -10.818395460648421 2.8372283190425414 0.9598591830085684 1.131487958747968 0.28346540678732424 0.0985481024005887 15750852.481796833 15736379.387643076 4350015.978087025 0.03606491218793827 1.519163577031823e-11 10.818395460648421 0.1716287757393996 LRPLFEACGEVVQIRPIFSNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LRPLFEACGEVVQIRPIFSNR 21 2 A0A499FI31;Q15020-4;Q15020 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 27801100.0 3515600.0 15387000.0 8898500.0 False True 5333422.224787098 12641069.630820286 7139707.574648894 1.0 2.37016105195476 1.3386728583885743 22.346630114013795 -10.127437242839026 4.7444712995279 0.9999391906745907 1.8544169551786562 0.4777659037844034 0.42110329168566335 0.0002758222107838966 5.072724183486395e-05 0.4077608642929105 0.1359105029735796 7.456976203102862e-11 10.127437242839026 0.8544777645040655 LRPLFEACGEVVQIRPIFSNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LRPLFEACGEVVQIRPIFSNR 21 2 A0A499FI31;Q15020-4;Q15020 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 8088690.0 944390.0 2386700.0 4757600.0 False True 1293556.504180134 2281247.702238538 3633952.8658476756 1.0 1.7635470077006106 2.8092726170867213 20.302911643462817 -6.966724919644141 0.32709854947617223 0.8682093302087465 3.738695783137593 0.9999444134222185 0.005529255622770205 0.0773804003934967 0.012821701160155893 0.015420548915975638 0.09142700017693856 1.0796303391661333e-07 6.966724919644141 2.8704864529288465 LRPLFEACGEVVQIRPIFSNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LRPLFEACGEVVQIRPIFSNR 21 2 A0A499FI31;Q15020-4;Q15020 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 16708000.0 3515600.0 8587200.0 4605200.0 False True 4551013.502836342 8109314.771244524 3767100.853342316 1.0 1.7818700749163963 0.8277498739554463 22.117756436106244 -6.688871255646958 1.8700678984456751 1.4906825722781916 0.8310562355472403 0.3653497606851248 0.33074930753068016 0.4190758601505166 2.8405088423693 0.14152485775227894 0.3691145480905669 2.047051384582459e-07 6.688871255646958 -0.6596263367309513 LRPLGLLVAMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LRPLGLLVAMK 11 1 Q9NPF0;Q9NPF0-2 Q9NPF0 CD320 CD320 antigen 0 3770690.0 987990.0 1709700.0 1073000.0 False True 1295264.4577087713 1454619.4243584026 961976.2529427853 1.0 1.1230289040212826 0.7426871379181139 20.304815256327213 -6.8196222434659175 1.373463036412989 1.0663379654878165 0.7344480607259938 0.883519129281895 0.05408364030580729 0.19397491854194404 0.7190974145284794 0.03094436690344637 0.0713306349060203 1.514878341812745e-07 6.8196222434659175 -0.3318899047618227 LRPLGLLVAMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LRPLGLLVAMK 11 1 Q9NPF0;Q9NPF0-2 Q9NPF0 CD320 CD320 antigen 0 2824690.0 987990.0 0.0 1836700.0 False True 1353276.6024258316 0.0 1402909.2880238846 1.0 0.0 1.0366759356580046 20.368025317850105 -10.482748247170719 5.012873905699056 1.0012297719960854 0.5183379678289824 0.22350058410224705 0.42322117849747676 0.005830417208463924 0.000601609053082796 0.4107448982173988 0.13659404800690686 3.2904231561256066e-11 10.482748247170719 -0.482891804167103 LRPNYDK(ub)SEVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LRPNYDKSEVEK 12 2 Q15751 Q15751 HERC1 Probable E3 ubiquitin-protein ligase HERC1 1 3909630.0 1360300.0 1901700.0 647630.0 True False 1783366.4731639377 1617973.7727685417 580619.4601056258 1.0 0.9072581531142242 0.32557495548042176 20.766171769588787 -6.934904575848235 0.7053803757686985 1.0074446993023873 0.18973737651525577 0.997417277390882 0.015168831272681189 0.09017019994472517 0.06578457878161795 0.014247544848242356 0.05128751784156719 1.1617038379572479e-07 6.934904575848235 -0.8177073227871315 down LRPVNQNK(ub)TVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LRPVNQNKTVK 11 2 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85;C9JAJ4;C9JZE0;C9JY20;C9J5B4;C9IZ22 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 13410000.0 4138500.0 6817400.0 2454100.0 True False 5425613.577291011 5800270.494017069 2200173.2733894615 1.0 1.069053372745562 0.4055160291175768 22.37135486906739 -6.881211381025933 1.0730591249989077 1.0435193511562415 0.3573927768667679 0.9746478467238732 0.047425631433068355 0.12656066744262454 0.2658689621086878 0.03400869820925711 0.08249803608656789 1.3145848380427704e-07 6.881211381025933 -0.6861265742894735 down LRPVNQNK(ub)TVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LRPVNQNKTVK 11 2 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85;C9JAJ4;C9JZE0;C9JY20;C9J5B4;C9IZ22 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 17755500.0 6253000.0 8383300.0 3119200.0 True False 6054501.937719145 11730795.40833195 2302187.9460057984 1.0 1.9375326870819667 0.38024398533318166 22.529576853515124 -6.74365823528498 1.6730451550278393 1.5554337767427429 0.37853161420408 0.6213931617020804 0.39389546306419065 0.3112197855347635 1.7117523328778013 0.18614178281626131 0.4549994608742883 1.8044371702875315e-07 6.74365823528498 -1.1769021625386629 LRPVNQNK(ub)TVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LRPVNQNKTVK 11 2 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85;C9JAJ4;C9JZE0;C9JY20;C9J5B4;C9IZ22 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 12590200.0 4138500.0 5239200.0 3212500.0 True False 5668615.288757275 5007714.820282465 2453773.66351431 1.0 0.8834105976841307 0.4328700288377214 22.43456493059028 -6.945668328639617 0.6045376458518033 1.0050283220009992 0.2880087443732568 0.9988159648165253 0.0084147141790785 0.08527328096784301 0.043531199621770524 0.008598187034288081 0.0379192585756609 1.1332655094404394e-07 6.945668328639617 -0.7170195776277424 down LRPVNQNK(ub)TVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LRPVNQNKTVK 11 2 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85;C9JAJ4;C9JZE0;C9JY20;C9J5B4;C9IZ22 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 16505820.0 6253000.0 9274500.0 978320.0 True False 5199646.554868829 9224536.427655881 1182882.1887594026 1.0 1.774069896927559 0.22749280672775324 22.3099821289494 -6.770620137645505 1.571969566900734 1.4436412064487956 0.21857035827978538 0.7329378163763587 0.32628883935148756 0.2654436404272419 1.294578126611228 0.16359645058343505 0.3892238146466802 1.6958204273952862e-07 6.770620137645505 -1.2250708481690102 LRQPFFQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LRQPFFQKR 9 2 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 1 7262600.0 2084300.0 3321500.0 1856800.0 True False 2732537.4843899133 2825945.147105595 1664676.147683284 1.0 1.0341834881494907 0.609205237693181 21.381809855952376 -6.887426353239148 1.037529674597514 1.0242634052179258 0.5744499901813214 0.9791976330692868 0.027805473681440953 0.12125437055851261 0.23426590503231728 0.020486425351055097 0.05061999644949845 1.2959064360207625e-07 6.887426353239148 -0.44981341503660444 LRQPFFQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LRQPFFQKR 9 2 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 1 10194600.0 4133900.0 3066600.0 2994100.0 True False 4002671.6072824607 4291109.372107736 2209855.3889253563 1.0 1.0720613113252888 0.5520951019076222 21.93253182632382 -6.871858954504565 1.1242784096503167 1.0412472817299139 0.5205562985876406 0.9665003768913732 0.04210005625951702 0.13508170222897994 0.31799470047661993 0.029028366698379122 0.06895321338065362 1.3432011207360127e-07 6.871858954504565 -0.5206909831422732 LRQPFFQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LRQPFFQKR 9 2 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 1 19335200.0 6424800.0 5903900.0 7006500.0 True False 9746891.315795923 4850302.917618758 5621662.2039419515 1.0 0.4976256285692139 0.5767646341589366 23.216510726810455 -10.724040147824791 6.881249171431598 1.005840491590613 0.5371951313641714 0.9785402184336517 0.032308363741014416 0.002906527075233064 0.00011656073881744826 0.0314080844120025 0.0104274795593467 1.8878168241009378e-11 10.724040147824791 -0.46864536022644154 LRQPFFQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LRQPFFQKR 9 2 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 1 7442500.0 2084300.0 2927600.0 2430600.0 True False 2854922.0360895954 2798248.9517214317 1856542.3397783295 1.0 0.9801489905322286 0.6502952852335145 21.445019917475268 -6.91922647341861 0.83046083909005 1.0074829909390985 0.598041419351172 0.9939629542519398 0.01246114386597747 0.09862899195598017 0.10799422358614452 0.010692785483946731 0.03179609673109506 1.2044077088945739e-07 6.91922647341861 -0.4094415715879265 LRQPFFQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LRQPFFQKR 9 2 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 1 17383700.0 4133900.0 10880000.0 2369800.0 True False 3437521.0128214136 10821387.280489095 2865314.2232828047 1.0 3.148020692855991 0.8335408605781994 21.712937101758097 -6.662904096209823 1.962365610294234 2.379311992219439 0.8430873779606478 0.2481264877723871 0.9139426904908531 0.477588158795466 3.538381272940129 0.37586023683200526 1.0136484237540944 2.1731810221387697e-07 6.662904096209823 -1.5362246142587912 LRQPFFQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LRQPFFQKR 9 2 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 1 25680800.0 6424800.0 15099000.0 4157000.0 True False 8317030.251741645 14258727.376912275 3400468.654421961 1.0 1.7144012881192054 0.4088561122775619 22.987637048902904 -6.758111985164068 1.6194867322195678 1.4159297084319906 0.40450970852265483 0.6832700000141425 0.30040357347223917 0.2860896250486115 1.4783884515373416 0.1463840248332235 0.3524554905923439 1.7453720413386596e-07 6.758111985164068 -1.0114199999093358 LRVDK(ub)AAAAAAALQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LRVDKAAAAAAALQAK 16 2 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 21072500.0 2215100.0 5678400.0 13179000.0 True False 2144782.8629844356 7945814.732464803 9727024.538474753 1.0 3.70471755887135 4.5352024703049585 21.0324001665351 -9.443758296262027 0.3615257153301015 3.087170394945908e-19 4.717669585154109 0.9983451940945373 0.06139874362424273 0.8050010697926573 0.1456063767184128 1.270213703937042 0.23397735987803223 3.5994960700732496e-10 9.443758296262027 4.717669585154109 LRVDK(ub)AAAAAAALQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LRVDKAAAAAAALQAK 16 2 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 12482000.0 2215100.0 7235700.0 3031200.0 True False 1841953.7955685179 7196719.847926004 3665009.905314725 1.0 3.9071120379025257 1.989740412670624 20.812805441969378 -9.303468020661356 9.39137515756114 1.000044313479308 2.9484262252866995 0.5792792703950738 0.7827636886034082 0.0 0.0 0.7579076823050948 0.2526358941016982 4.972009838455835e-10 9.303468020661356 1.9483819118073915 LSAAK(ub)MVYYLDPSSQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSAAKMVYYLDPSSQK 16 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 5605200.0 2231200.0 2293600.0 1080400.0 True False 2925124.806971533 1951403.8203827755 968610.5719285989 1.0 0.667118139961734 0.33113478427316395 21.480066751133908 -7.290544547435852 0.27519499812740406 1.094929300246118 4.607634715615262e-13 0.9999131235158608 0.0025451568011059223 0.10371465156522942 0.018081616461159713 0.014032631448453238 0.047318601054548874 5.122187271120228e-08 7.290544547435852 -1.0949293002456573 down LSAAK(ub)MVYYLDPSSQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSAAKMVYYLDPSSQK 16 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 10313100.0 2979400.0 2965600.0 4368100.0 True False 2884820.5778411073 4149779.5453996956 3223963.5698089064 1.0 1.4384879175068963 1.1175612079908281 21.4600501621955 -10.374656179319384 5.322288736039564 0.9998694361981932 1.2780245627488696 0.5001688612221911 0.1310177805241537 0.00020307480935034258 2.386034781883991e-05 0.12691666577508368 0.04228580683558838 4.220304827716156e-11 10.374656179319384 0.2781551265506763 LSAAK(ub)MVYYLDPSSQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSAAKMVYYLDPSSQK 16 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 9001200.0 2979400.0 3744600.0 2277200.0 True False 2477503.10979949 3724427.096555093 2753351.991416832 1.0 1.503298656548011 1.1113414875348702 21.240455437629777 -10.226988282355876 6.332553536474537 0.9999960875309306 1.3073200720414409 0.450452271522669 0.1600158441846712 8.839102429864052e-06 1.078812284171754e-06 0.15493664606424978 0.05164489163804592 5.929413224385112e-11 10.226988282355876 0.30732398451051024 LSAASTWLEDEGVGATTVMLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSAASTWLEDEGVGATTVMLK 21 0 Q9Y4L1;A0A494C039;A0A087X054 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 9231600.0 2892900.0 2723600.0 3615100.0 False True 2801066.4729933967 3811147.683386369 2668196.859324692 1.0 1.3606059406771365 0.9525646338814973 21.417544790194643 -6.67343375083881 1.9250888620088578 1.229492275072454 0.9541843025940371 0.29433941889934523 0.15305787581430108 0.45331517494324514 3.2419840907176463 0.06393168273946777 0.17005525363261326 2.1211249339962806e-07 6.67343375083881 -0.2753079724784169 LSAAVTEAFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSAAVTEAFVR 11 0 P26640;A0A140T936;P26640-2 P26640 VARS Valine--tRNA ligase 0 13074900.0 2907100.0 3282300.0 6885500.0 False True 3981933.4314235323 3137277.132885386 5259286.711323822 1.0 0.7878778455027603 1.3207872009662498 21.92503767211089 -6.798695237122428 1.4610894040241704 0.8827614909329383 1.327918141183825 0.8283130280817856 0.09076853071162301 0.22265556340699685 0.9385086345906272 0.04887349424411681 0.11376056325821077 1.5896618905245084e-07 6.798695237122428 0.4451566502508867 LSAEAAEK(ub)LK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSAEAAEKLK 10 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 5894920.0 863120.0 2291400.0 2740400.0 True False 1131558.6784659708 1949532.051807243 2456849.6957729817 1.0 1.7228731385368194 2.171208389390534 20.109879968720737 -8.801419732383257 0.14052918290285382 2.110573317382105e-09 3.0404973722376516 0.99989186868502 0.005017358658508001 0.329571198810159 0.041726647594813045 0.48233197000387795 0.34749671286368733 1.5797205494781239e-09 8.801419732383257 3.040497370127078 LSAEAAEK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSAEAAEKLK 10 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 12922800.0 2841500.0 2813500.0 7267800.0 True False 2751298.137858465 3936945.2222086773 5364145.1506735515 1.0 1.4309409685687817 1.9496778909060197 21.391681051655322 -6.96865581193175 0.28849435264903683 0.8967995799130889 2.499812452061661 0.9999699150486354 0.002129567995777289 0.07674137132204782 0.010583703602272896 0.00913663921713217 0.04712394661232767 1.074840910287741e-07 6.96865581193175 1.6030128721485721 LSAEAAEK(ub)LK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSAEAAEKLK 10 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 34230100.0 5418300.0 2593800.0 26218000.0 True False 8219957.230789606 2130916.1245481027 21036000.8082424 1.0 0.259236887093074 2.55913750128134 22.970699456772707 -6.820023356013549 1.3718196959277746 0.6007417027670453 2.6093519141568313 0.8844232997519097 0.3258706006329575 0.19345426715649452 0.7153582261770972 0.18667155328028995 0.43023536581044164 1.513479852498778e-07 6.820023356013549 2.008610211389786 LSAEAAEK(ub)LK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSAEAAEKLK 10 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 6864320.0 863120.0 2732700.0 3268500.0 True False 1182238.7889409645 2611960.2781695477 2496547.6168705113 1.0 2.209333937105304 2.111711813403525 20.17309003024363 -10.383572707822175 6.52772369295769 0.9998901533883362 2.1605228752544146 0.9947210001344927 0.03985406511270319 6.371812136020318e-05 6.016914175125331e-06 0.03859207875243985 0.012862844205013758 4.1345408974494025e-11 10.383572707822175 1.1606327218660784 LSAEAAEK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSAEAAEKLK 10 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 10522500.0 2841500.0 5674700.0 2006300.0 True False 2362833.1497936677 5644129.264760236 2425808.053916909 1.0 2.38871257805618 1.0266522856803242 21.1720863270896 -6.6417473917555085 2.0390293018486156 1.9069709560766215 1.0324262299481763 0.1610744909564914 0.5939382934214777 0.5289247096403644 4.2053781655932205 0.23708295886768724 0.6573463416383806 2.2816688232937697e-07 6.6417473917555085 -0.8745447261284451 LSAEAAEK(ub)LK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSAEAAEKLK 10 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 27121500.0 5418300.0 4415800.0 17287400.0 True False 7014096.1606605295 4170056.848199834 14141270.58370319 1.0 0.594525189373385 2.0161215728715476 22.741825778865156 -6.830480273619924 1.3258128150630142 0.7834163729212849 2.054738981203649 0.9068246598486516 0.1825206803746739 0.18021794677148956 0.6193848361435809 0.10808698263952417 0.2487289570330842 1.4774735893814215e-07 6.830480273619924 1.271322608282364 up LSAEEQAK(ub)FR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSAEEQAKFR 10 1 Q96ST3 Q96ST3 SIN3A Paired amphipathic helix protein Sin3a 1 8836200.0 1632000.0 2070800.0 5133400.0 True False 2112656.171529443 1955558.1596205046 4199173.873131993 1.0 0.9256395744721639 1.9876276744511767 21.010626561399828 -6.8900999654744775 1.0217650822463469 0.9430749773669777 2.0791565261057703 0.9809631178633655 0.06678668442575862 0.11906311094255911 0.22136143388192506 0.04979637309234331 0.12419103635257547 1.287953057809602e-07 6.8900999654744775 1.1360815487387925 LSAEK(ub)VEIATLTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSAEKVEIATLTR 13 1 P25789;H0YN18;H0YMZ1;H0YL69;P25789-2 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type 1 23460000.0 4633500.0 6510500.0 12316000.0 True False 7029358.254224326 5348650.408231325 9881737.201705426 1.0 0.7609016662391661 1.4057808471729192 22.74496155368468 -6.806307633109509 1.4298793636044242 0.8691119374498434 1.416146621215524 0.8499914432629885 0.1030963661429345 0.21188270310478868 0.8544535587786349 0.05670347949808601 0.1314069161343445 1.5620407768722668e-07 6.806307633109509 0.5470346837656807 LSAEK(ub)VEIATLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSAEKVEIATLTR 13 1 P25789;H0YN18;H0YMZ1;H0YL69;P25789-2 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type 1 4042890.0 879360.0 877730.0 2285800.0 True False 1204483.155810461 838948.986335037 1745941.1175287194 1.0 0.6965219748303854 1.4495355199499884 20.199982787559225 -6.79731366174272 1.4668304586890077 0.8319807596184249 1.4592559185054683 0.8241878508127873 0.12970533601179585 0.22462206069542542 0.9543942865502006 0.06957286806589441 0.16207461329116987 1.594726967008423e-07 6.79731366174272 0.6272751588870434 LSAEK(ub)VEIATLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSAEKVEIATLTR 13 1 P25789;H0YN18;H0YMZ1;H0YL69;P25789-2 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type 1 24337800.0 4633500.0 7040300.0 12664000.0 True False 5998157.089939756 6648501.116078919 10359281.943613112 1.0 1.108423973628489 1.7270774653414682 22.516087875777128 -6.936908098969072 0.6877281801080926 0.9925462115378126 1.8797526484332585 0.9977302139887588 0.015258171655727603 0.08920589383851311 0.06124832432053738 0.014525355234111293 0.054011377857680766 1.1563569129252157e-07 6.936908098969072 0.8872064368954459 LSAEQAK(ub)QLVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSAEQAKQLVSR 12 1 Q8N163;Q8N163-2;H0YB24;G3V119;A0A087X2B6 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 1 10493000.0 7230900.0 3262100.0 0.0 True False 10969803.949599799 2679952.7680963697 0.0 1.0 0.2443027040783295 0.0 23.38703440659188 -9.106203192134531 0.4675005736518706 1.1296894058227034 4.923078464684155e-24 0.9966017727374596 0.024814199152719874 0.5869965161235962 0.201345889580238 0.2042213143340653 0.052893752732410954 7.83063187481419e-10 9.106203192134531 -1.1296894058227034 LSAFGQIYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSAFGQIYK 9 0 Q96SI9-2;Q96SI9 Q96SI9-2 STRBP Spermatid perinuclear RNA-binding protein 0 7432400.0 3024100.0 2282400.0 2125900.0 False True 4142191.4932296383 2181556.0211125133 1623806.2042848456 1.0 0.5266671095912007 0.3920162085550456 21.981962820117456 -13.999999999999998 0.1763170093674786 3.4290638873224557 0.2808883016550383 0.9995030455334997 0.00581230471417645 12.159297250180705 0.13307208752246458 10.110748934201494 0.10377272519305604 1.0000000000000041e-14 13.999999999999998 -3.1481755856674174 LSAFGQIYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSAFGQIYK 9 0 Q96SI9-2;Q96SI9 Q96SI9-2 STRBP Spermatid perinuclear RNA-binding protein 0 2494600.0 0.0 1109400.0 1385200.0 False True 0.0 1103423.4420013416 1674838.915558841 0.0 LSAK(ub)FGGQA ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSAKFGGQA 9 1 P50502;Q8NFI4 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 269629000.0 95080000.0 96198000.0 78351000.0 True False 124650800.7560299 81845633.37686715 70243990.1158623 1.0 0.6565993389569775 0.5635261842669252 26.893316909822758 -13.999999999999998 0.18321322154706438 2.799748718258607 0.491995157788598 0.9994946128060712 0.004219741525378547 12.247975905425573 0.13571403428461515 7.853276122114119 0.06763950341531832 1.0000000000000041e-14 13.999999999999998 -2.307753560470009 LSAK(ub)FGGQA ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSAKFGGQA 9 1 P50502;Q8NFI4 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 360068000.0 110530000.0 95278000.0 154260000.0 True False 107021285.65106308 133323002.26820602 113854678.29919682 1.0 1.245761546005887 1.0638507807728421 26.673322524409194 -10.288453189107416 4.457705532275945 0.9998957869539509 1.1548061633905375 0.49125016469890226 0.0742647589273425 7.696786193739103e-05 1.2285748352942798e-05 0.0719548671102802 0.023968847877417807 5.1469128057106125e-11 10.288453189107416 0.15491037643658667 LSAK(ub)FGGQA ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSAKFGGQA 9 1 P50502;Q8NFI4 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 725260000.0 243080000.0 299000000.0 183180000.0 True False 368770131.5284016 245641113.90233746 146974392.70935386 1.0 0.666109028093613 0.39855286571123594 28.458146568768306 -7.519615513237804 0.19826273191411037 1.203889258770668 1.0006530389618302e-10 0.9999491630730708 0.0017542352382665472 0.1299531988689525 0.01900899901555628 0.033807883524264115 0.06759925309941164 3.0226265082286006e-08 7.519615513237804 -1.2038892586706027 down LSAK(ub)FGGQA ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSAKFGGQA 9 1 P50502;Q8NFI4 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 294237000.0 95080000.0 80477000.0 118680000.0 True False 130233645.44038713 76921260.03814934 90650228.29132393 1.0 0.5906404583703304 0.6960584416169013 26.95652697134565 -10.030428906701275 7.136752055446765 1.0000000429194753 0.6433494499936198 0.938504778498139 0.04303671144456119 2.937390275552718e-08 4.045733599807355e-09 0.04167012195299063 0.013890038891693232 9.323330792555899e-11 10.030428906701275 -0.35665059292585555 LSAK(ub)FGGQA ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSAKFGGQA 9 1 P50502;Q8NFI4 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 414570000.0 110530000.0 192350000.0 111690000.0 True False 91910592.30923589 191313772.3715142 135043862.60378778 1.0 2.081520394600803 1.4692959669917993 26.45372779984347 -10.54835993224647 6.319805568545599 0.9989154434055825 1.7754081807962672 0.6814109113145177 0.2499395759515928 0.0038237708471715814 0.0002732627253085748 0.24228080930110096 0.0806676512682219 2.8290463820860632e-11 10.54835993224647 0.7764927373906847 LSAK(ub)FGGQA ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSAKFGGQA 9 1 P50502;Q8NFI4 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 655800000.0 243080000.0 300710000.0 112010000.0 True False 314671851.8231479 283975224.1546656 91625329.31965455 1.0 0.9024487653069952 0.2911773925401815 28.229272890860756 -6.934923001704815 0.7052090014831697 1.007818422875367 0.14835343811533638 0.9974204710037308 0.015931891542109087 0.09016086897434698 0.06573921364540244 0.01496618974172176 0.053891168677389745 1.161654551274776e-07 6.934923001704815 -0.8594649847600306 down LSAK(ub)PAPPKPEPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSAKPAPPKPEPK 13 2 P05204;A0A087WZE9;Q15651-2;Q15651 P05204 HMGN2;HMGN3 Non-histone chromosomal protein HMG-17;High mobility group nucleosome-binding domain-containing protein 3 1 7578800.0 2362400.0 3635100.0 1581300.0 True False 3097129.2775141457 3092757.249508823 1417682.2449006801 1.0 0.9985883611520304 0.4577407392043244 21.562500173239552 -6.9074709743893905 0.9127860541521017 1.0181143672198762 0.39149852659135165 0.9899316413539737 0.025616246712263337 0.10611422336239079 0.1480151754436665 0.02071356723011217 0.056224756889172875 1.2374538910887114e-07 6.9074709743893905 -0.6266158406285246 down LSAK(ub)PAPPKPEPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSAKPAPPKPEPK 13 2 P05204;A0A087WZE9;Q15651-2;Q15651 P05204 HMGN2;HMGN3 Non-histone chromosomal protein HMG-17;High mobility group nucleosome-binding domain-containing protein 3 1 14097700.0 5697200.0 5797700.0 2602800.0 True False 5516345.504489618 8112751.844606084 1921048.597673732 1.0 1.4706750760994418 0.34824660567584786 22.39528138912087 -6.792777479153505 1.4850976709155825 1.2621065190169598 0.33535594859850215 0.8102576624954994 0.2004660842018881 0.23122073405052324 1.0073392957516474 0.10623077779922938 0.2482315155160954 1.611471098265209e-07 6.792777479153505 -0.9267505704184577 down LSAK(ub)PAPPKPEPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSAKPAPPKPEPK 13 2 P05204;A0A087WZE9;Q15651-2;Q15651 P05204 HMGN2;HMGN3 Non-histone chromosomal protein HMG-17;High mobility group nucleosome-binding domain-containing protein 3 1 4989700.0 1944700.0 1773800.0 1271200.0 True False 2950252.076613798 1457251.5312373438 1019946.7628132466 1.0 0.49394136276989903 0.34571512410692307 21.492406796389773 -13.999999999999998 0.17214359692134446 3.5667055176749467 0.21790235027017643 0.9995097523586778 0.006202065544758473 12.11311031477682 0.1314261484150827 10.384463775517103 0.1185286731269796 1.0000000000000041e-14 13.999999999999998 -3.3488031674047702 LSAK(ub)PAPPKPEPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSAKPAPPKPEPK 13 2 P05204;A0A087WZE9;Q15651-2;Q15651 P05204 HMGN2;HMGN3 Non-histone chromosomal protein HMG-17;High mobility group nucleosome-binding domain-containing protein 3 1 16260930.0 5697200.0 9602900.0 960830.0 True False 4737474.228753999 9551167.271673579 1161735.110624025 1.0 2.016088491564339 0.24522246550132107 22.175686664555148 -6.751079952475809 1.6456769588068108 1.5966867602471841 0.24137373877780893 0.6536773043371747 0.4269931819220095 0.29816410834091583 1.5890592450451855 0.2049297265351936 0.49698455118663304 1.7738628873204125e-07 6.751079952475809 -1.3553130214693752 LSAKPAPPKPEPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSAKPAPPKPEPK 13 2 P05204;A0A087WZE9;Q15651-2;Q15651 P05204 HMGN2;HMGN3 Non-histone chromosomal protein HMG-17;High mobility group nucleosome-binding domain-containing protein 3 0 5055780.0 1494800.0 581480.0 2979500.0 False True 1447348.392212151 813667.9963781403 2199079.566915967 1.0 0.5621783951647722 1.5193850898295866 20.464980805097372 -6.78232751502767 1.526642290129193 0.7528443885647476 1.5275500262566435 0.7755895258283568 0.1853431661754515 0.24697579625637958 1.1370462558744099 0.09560435520112225 0.22516640419243283 1.6507164718907446e-07 6.78232751502767 0.7747056376918959 LSALGNVTTCNDYVALVHPDLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSALGNVTTCNDYVALVHPDLDR 23 0 P56537 P56537 EIF6 Eukaryotic translation initiation factor 6 0 11997700.0 4794600.0 2895800.0 4307300.0 False True 4642398.047431348 4052108.0413975082 3179088.91376981 1.0 0.8728480410333516 0.6847945568839813 22.14643879653812 -6.965490839856036 0.3495257265771952 1.018272558334203 0.5330290584189923 0.9999229070951667 0.0011368551095606739 0.07779480479908461 0.014274848765439776 0.002584455379669044 0.016168814746610242 1.0827025512605253e-07 6.965490839856036 -0.48524349991521065 LSAMLVPVTPEVKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSAMLVPVTPEVKPK 15 1 P82970;Q5JSL0;Q5JSK6;Q5JSK7;Q5JSK8 P82970 HMGN5 High mobility group nucleosome-binding domain-containing protein 5 0 7475700.0 1869000.0 3197600.0 2409100.0 False True 2450277.0994217466 2720530.5441471757 2159829.4417189825 1.0 1.110295053889704 0.8814633423414404 21.224513480738118 -6.775634957983459 1.5527267653241312 1.0628069995269822 0.8798884784600063 0.7516657771412051 0.04656426356517458 0.25743142888057086 1.2255417047551609 0.023626664993645366 0.055959342766423024 1.6763513248694088e-07 6.775634957983459 -0.18291852106697593 LSAMLVPVTPEVKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSAMLVPVTPEVKPK 15 1 P82970;Q5JSL0;Q5JSK6;Q5JSK7;Q5JSK8 P82970 HMGN5 High mobility group nucleosome-binding domain-containing protein 5 0 7460300.0 1869000.0 2477800.0 3113500.0 False True 2560019.8078258657 2368322.603011125 2378155.4245453067 1.0 0.9251188587569786 0.9289597749499408 21.28772354226101 -10.605834634417386 6.010938354506119 1.0003117347217618 0.9270393168534596 0.9979257683011411 0.0015680474695917539 6.578583013877104e-06 4.3138853047259194e-07 0.0015247154169351301 0.000506085144649298 2.4783655610982504e-11 10.605834634417386 -0.07327241786830219 LSAQLTHASSLGYNGAILQALAVHLALQGESSSEHFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSAQLTHASSLGYNGAILQALAVHLALQGESSSEHFLK 38 0 Q9NX46 Q9NX46 ADPRHL2 Poly(ADP-ribose) glycohydrolase ARH3 0 480090000.0 176808000.0 123418000.0 179864000.0 False True 268230662.3962216 101393093.63076483 144313801.56280816 1.0 0.3780070955534168 0.5380212697295305 27.998898925343745 -10.48114501043065 9.351965974139786 1.0000076150667365 0.458014182642065 0.9386378730120689 0.06532551305738521 1.0372136540305236e-05 5.753841528411395e-07 0.06325204313105288 0.02108371867947567 3.30259249439168e-11 10.48114501043065 -0.5419934324246716 LSAQLTHASSLGYNGAILQALAVHLALQGESSSEHFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSAQLTHASSLGYNGAILQALAVHLALQGESSSEHFLK 38 0 Q9NX46 Q9NX46 ADPRHL2 Poly(ADP-ribose) glycohydrolase ARH3 0 302789000.0 176808000.0 43209000.0 82772000.0 False True 228881441.40672642 40804381.16623636 67708345.31244034 1.0 0.1782773689096367 0.2958227844787179 27.770025247436195 -10.802515757579112 7.325681641232484 1.0272765440374803 0.23705007669418537 0.9825089014218675 0.047987714957941754 0.018272827345252155 0.0004925945004083931 0.039714776703531615 0.015487968404554747 1.5757388489112737e-11 10.802515757579112 -0.7902264673432948 LSASLLHSHDTETR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSASLLHSHDTETR 14 0 Q9HCU5;B5MC98 Q9HCU5 PREB Prolactin regulatory element-binding protein 0 3579880.0 1514900.0 903680.0 1161300.0 False True 1986048.5703124676 768854.4665170504 1041139.8159761961 1.0 0.38712772588239647 0.5242267644100931 20.921469474814877 -9.995606298640453 7.260306731908472 1.000000027774754 0.4556772451470401 0.9545817662743716 0.05597044810317216 2.516595886720199e-08 3.559258930297822e-09 0.054193155768448624 0.01806438444861258 1.0101682198117044e-10 9.995606298640453 -0.5443227826277139 LSAYVSYGGLLMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSAYVSYGGLLMR 13 0 C9JLU1;P52434;P52434-3 C9JLU1 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 0 4780900.0 1774700.0 1706500.0 1299700.0 False True 2326648.8862192445 1451896.8518849013 1165219.5116027403 1.0 0.6240292037550209 0.5008145055768158 21.149822079882643 -13.999999999999998 0.1559622453885771 2.836687244641784 0.3741252104067123 0.9995475746566563 0.004516127177191421 11.985171815912679 0.12465166901624061 6.662174945088438 0.11490905869456905 1.0000000000000041e-14 13.999999999999998 -2.462562034235072 LSAYVSYGGLLMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LSAYVSYGGLLMR 13 0 C9JLU1;P52434;P52434-3 C9JLU1 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 0 42440400.0 17403500.0 11374500.0 13662400.0 False True 16851035.418694254 15916397.16723391 10083807.576785605 1.0 0.9445352627753977 0.5984087817890882 24.00633390532319 -6.935009046522526 0.7044639689570905 1.004415014207129 0.5173478078951266 0.9974343497425406 0.009000265650811782 0.09011913389956244 0.06554171798376754 0.008459452047186034 0.030502191898836312 1.1614244206671536e-07 6.935009046522526 -0.4870672063120025 LSAYVSYGGLLMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 LSAYVSYGGLLMR 13 0 C9JLU1;P52434;P52434-3 C9JLU1 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 0 313812000.0 96695000.0 112297000.0 104820000.0 False True 146693384.35140187 92256722.96953441 84102281.05576201 1.0 0.6289085453815338 0.5733202040952046 27.12822856822445 -13.999999999999998 0.26731761729062403 3.8234144862842148 0.5543833790957632 0.9995775930645295 0.003892667090581742 14.753193753542542 0.16364819825577054 22.600594105424403 0.023400628282933898 1.0000000000000041e-14 13.999999999999998 -3.2690311071884515 LSAYVSYGGLLMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSAYVSYGGLLMR 13 0 C9JLU1;P52434;P52434-3 C9JLU1 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 0 11369100.0 1774700.0 3677900.0 5916500.0 False True 2430854.549464183 3515398.2168111308 4519144.554142384 1.0 1.4461573678219484 1.859076494370471 21.213032141405535 -6.972054742887985 0.20320739145959923 0.7641661920411444 2.5525081589260545 0.9999942840175446 0.0008386865756325304 0.07564147231447044 0.006587397496634761 0.013058867232472779 0.04348719537739784 1.0664616850938711e-07 6.972054742887985 1.78834196688491 LSAYVSYGGLLMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LSAYVSYGGLLMR 13 0 C9JLU1;P52434;P52434-3 C9JLU1 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 0 39548500.0 17403500.0 10312700.0 11832300.0 False True 14471781.35577478 10257143.438189331 14306379.223626105 1.0 0.7087685465961209 0.9885707137164096 23.786739180757465 -10.66140743120021 9.025382873538675 1.0001330449888899 0.8486696302390352 0.280586772448275 0.11422875639494197 0.00030606951203764667 1.1482359861628934e-05 0.11069791326320277 0.036867172597966145 2.1806831548998593e-11 10.66140743120021 -0.1514634147498547 LSAYVSYGGLLMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LSAYVSYGGLLMR 13 0 C9JLU1;P52434;P52434-3 C9JLU1 POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 0 296725000.0 96695000.0 110787000.0 89243000.0 False True 125173583.64340654 104621606.06040017 73001689.71050741 1.0 0.8358121818933085 0.5832036407815407 26.8993548903169 -6.96483229709716 0.36091984913960706 1.0215398195211793 0.3888070294931373 0.9999096444481054 0.0016295074914561326 0.07801793529215059 0.015060953607216147 0.00338287832724763 0.02156413989310313 1.0843455534439641e-07 6.96483229709716 -0.6327327900280421 LSCLAVGLALLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSCLAVGLALLK 12 0 E9PFK5;P78316-2;P78316 E9PFK5 NOP14 Nucleolar protein 14 0 20548800.0 5494900.0 7960000.0 7093900.0 False True 8336165.030999724 6539475.808236127 5691787.555633182 1.0 0.7844705309837026 0.6827824946443734 22.990952408246756 -13.999999999831008 0.1000123438768509 2.0643622159402883 0.46623924929724464 0.9997936541846693 0.001899787457444767 12.080309713929692 0.0941831067741601 2.6536852019080612 0.1931260099095368 1.0000000003891183e-14 13.999999999831008 -1.5981229666430437 LSCLAVGLALLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSCLAVGLALLK 12 0 E9PFK5;P78316-2;P78316 E9PFK5 NOP14 Nucleolar protein 14 0 2164640.0 321430.0 629910.0 1213300.0 False True 440271.35731913784 602078.4933661859 926743.5286978716 1.0 1.3675168355995495 2.1049371331828577 18.748033464526358 -6.9599813367969725 0.4356962542202643 0.9724180923312067 2.5285823789568993 0.999769507802603 0.006975160118155473 0.07970778320561354 0.02115590732516904 0.009673039814225853 0.061152096590720885 1.0965253167854e-07 6.9599813367969725 1.5561642866256926 up LSCLAVGLALLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSCLAVGLALLK 12 0 E9PFK5;P78316-2;P78316 E9PFK5 NOP14 Nucleolar protein 14 0 13007600.0 5494900.0 3827400.0 3685300.0 False True 7113256.370672266 3614401.825444998 3014613.2143712435 1.0 0.5081219679283688 0.42380213186191346 22.762078730339205 -13.999999999999998 0.24811597043553943 4.388567896804084 0.38928562550842294 0.99953918366413 0.005454464369637822 13.924084232968314 0.1576234387684333 23.48959368708134 0.039324965291880405 1.0000000000000041e-14 13.999999999999998 -3.9992822712956615 LSCSCISWNPSSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSCSCISWNPSSSR 14 0 Q96EE3;Q96EE3-1;K7ENI5;K7EP88 Q96EE3 SEH1L Nucleoporin SEH1 0 11995900.0 4165300.0 3505300.0 4325300.0 False True 5460748.6368225785 2982322.903552384 3877759.4472073037 1.0 0.5461381033805824 0.710114986992633 22.380667319112778 -10.094229525823312 4.830173373511005 1.0000156807470026 0.6281265451832311 0.872732550498407 0.06694328242184862 93143373.53850193 7.40066814701121 16244.105385196988 0.022916466158170723 8.049529089441732e-11 10.094229525823312 -0.37188913556377157 LSCSCISWNPSSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSCSCISWNPSSSR 14 0 Q96EE3;Q96EE3-1;K7ENI5;K7EP88 Q96EE3 SEH1L Nucleoporin SEH1 0 9165200.0 4165300.0 2769300.0 2230600.0 False True 5705323.973000041 2646943.169149531 1703778.2206490322 1.0 0.4639426580639353 0.29862953071762743 22.44387738063567 -13.999999999999998 0.16475160234252714 3.6682396072818175 0.14434734134949842 0.9995246844341159 0.006526801975003187 12.044751377627243 0.12841376891804454 10.268180056654426 0.1415011915553492 1.0000000000000041e-14 13.999999999999998 -3.5238922659323193 LSDGVAVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSDGVAVLK 9 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 83656100.0 5782100.0 38219000.0 39655000.0 False True 7580389.093936045 32516874.17649516 35551880.99761994 1.0 4.289604896733748 4.689981023013684 22.853840471742323 -9.907128268245804 0.514855639576345 2.949606840845448e-13 4.674373164140772 0.9991582940624557 0.047963043058748184 1.1886556633023224 0.23450428711025492 2.0266384668127255 0.07883439220969564 1.238430763779202e-10 9.907128268245804 4.674373164140477 LSDGVAVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSDGVAVLK 9 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 63105500.0 30393000.0 6751500.0 25961000.0 False True 29428190.85128708 9447409.158607377 19161035.286694236 1.0 0.3210326182247857 0.6511115611395528 24.81069551705378 -10.578538993987259 6.519366099013582 1.000918847862273 0.4860720896825568 0.7637201256370968 0.1347541641630727 0.0018025439837529638 0.00011653017999717473 0.13068348964731863 0.043491719469640096 2.6391313521099585e-11 10.578538993987259 -0.5148467581797163 LSDGVAVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSDGVAVLK 9 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 271936300.0 2502800.0 266500000.0 2933500.0 False True 3796930.579189091 218940992.82599628 2353692.439201277 1.0 57.662627287948844 0.619893461340016 21.85640219114786 -3.5343821147867884 13.286256547297299 9.999999999999947 28.105378206857704 0.0 28.523162743441457 0.0 0.0 10.351326024824003 0.0 0.0002921580688594128 3.5343821147867884 18.105378206857758 LSDGVAVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSDGVAVLK 9 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 93861100.0 5782100.0 56462000.0 31617000.0 False True 7919898.625377166 53967322.14513448 24149715.772554673 1.0 6.814143046251986 3.049245566751759 22.917050533265215 -9.571017714289757 9.768418654799698 0.9999904906524296 4.931694306501873 0.5925173303626632 1.5370129597874806 0.0 0.0 1.4882063990360397 0.4960687996786798 2.6852349162919896e-10 9.571017714289757 3.9317038158494433 LSDGVAVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSDGVAVLK 9 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 33531100.0 30393000.0 1547500.0 1590600.0 False True 25273126.138194222 1539163.3103453002 1923187.1058965449 1.0 0.06090118420369164 0.07609613054516878 24.591100792488056 -10.694162046633764 3.030211268566395 1.110261605954423 0.06849865642339993 0.9998004706618432 0.0062033138265618565 7482374.735163322 7341086.038663 6326416.073555258 0.002377272125975091 2.0222644781019217e-11 10.694162046633764 -1.041762949531023 LSDGVAVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSDGVAVLK 9 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 12767700.0 2502800.0 5171200.0 5093700.0 False True 3239923.9375636624 4883418.174149863 4166698.8657755977 1.0 1.5072632161303348 1.286048359798485 21.62752851324031 -10.113735028688735 4.541804366035626 0.9999625742515614 1.396655787976353 0.8108512610273468 0.09031058696335054 62949462.33066492 2.231480155031815 24638.19264349624 0.030915716032281253 7.695998445567532e-11 10.113735028688735 0.3966932137247916 LSDIPEGK(ub)NMAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSDIPEGKNMAFK 13 1 P47985;P0C7P4 P47985 UQCRFS1;UQCRFS1P1 Cytochrome b-c1 complex subunit Rieske, mitochondrial;Cytochrome b-c1 complex subunit 11;Putative cytochrome b-c1 complex subunit Rieske-like protein 1 1 28808800.0 9460300.0 6868500.0 12480000.0 True False 12402544.913675534 5843746.573203308 11188689.316613222 1.0 0.4711731837197189 0.9021285062452088 23.564132845922646 -10.008423716609395 7.093945953379483 1.0000000289627613 0.6866508449824659 0.413457447445151 0.1759367736873347 8.052681085412815e-08 1.1450502676260905e-08 0.17035006384957063 0.056783349539709115 9.807905740745363e-11 10.008423716609395 -0.31334918398029543 LSDIPEGK(ub)NMAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSDIPEGKNMAFK 13 1 P47985;P0C7P4 P47985 UQCRFS1;UQCRFS1P1 Cytochrome b-c1 complex subunit Rieske, mitochondrial;Cytochrome b-c1 complex subunit 11;Putative cytochrome b-c1 complex subunit Rieske-like protein 1 1 29259800.0 12910000.0 7871600.0 8478200.0 True False 12500179.116576731 11014770.929851713 6257505.079451909 1.0 0.8811690478294675 0.5005932331924516 23.575445431798546 -6.949972554419288 0.5591459570965109 1.0049998420217134 0.3586007922981508 0.9991991195947377 0.006028192279127854 0.08349678508436024 0.03600814969775192 0.006468562962394178 0.03163031402104799 1.1220893633795392e-07 6.949972554419288 -0.6463990497235627 LSDIPEGK(ub)NMAFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSDIPEGKNMAFK 13 1 P47985;P0C7P4 P47985 UQCRFS1;UQCRFS1P1 Cytochrome b-c1 complex subunit Rieske, mitochondrial;Cytochrome b-c1 complex subunit 11;Putative cytochrome b-c1 complex subunit Rieske-like protein 1 1 65378000.0 15394000.0 23063000.0 26921000.0 True False 23353823.45214834 18947227.45795852 21600052.550106548 1.0 0.8113115823103281 0.9249043350166946 24.47715542930224 -10.258004041451041 5.049526526423309 1.0000236314060051 0.8681079586790326 0.6425410281323019 0.04637404710167194 1.2339455416423584e-05 1.8131762448653588e-06 0.044909519627462306 0.014967159343387213 5.5207230179075135e-11 10.258004041451041 -0.13191567272697258 LSDIPEGK(ub)NMAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSDIPEGKNMAFK 13 1 P47985;P0C7P4 P47985 UQCRFS1;UQCRFS1P1 Cytochrome b-c1 complex subunit Rieske, mitochondrial;Cytochrome b-c1 complex subunit 11;Putative cytochrome b-c1 complex subunit Rieske-like protein 1 1 30811300.0 9460300.0 8604000.0 12747000.0 True False 12958028.564994682 8223846.830376836 9736421.132705638 1.0 0.634652623979627 0.7513813605109639 23.627342907445538 -10.750651535945973 10.151250926521241 1.000903473690266 0.6930169922452957 0.902169086849289 0.04765430713692499 0.0009768369435743346 2.3994367546791435e-05 0.04625626152900521 0.015380361493030308 1.7756136052568983e-11 10.750651535945973 -0.30788648144497033 LSDIPEGK(ub)NMAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSDIPEGKNMAFK 13 1 P47985;P0C7P4 P47985 UQCRFS1;UQCRFS1P1 Cytochrome b-c1 complex subunit Rieske, mitochondrial;Cytochrome b-c1 complex subunit 11;Putative cytochrome b-c1 complex subunit Rieske-like protein 1 1 29888300.0 12910000.0 10822000.0 6156300.0 True False 10735237.009972287 10763699.738001175 7443553.86648491 1.0 1.0026513367150114 0.6933758294828859 23.355850707232822 -6.9049651814544255 0.9293301020687016 1.011166214214434 0.6574280773629274 0.988879114761512 0.015309303934260889 0.10784266610781731 0.15751929432456888 0.012229931526142983 0.032691437155911704 1.24461439182296e-07 6.9049651814544255 -0.35373813685150657 LSDIPEGK(ub)NMAFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSDIPEGKNMAFK 13 1 P47985;P0C7P4 P47985 UQCRFS1;UQCRFS1P1 Cytochrome b-c1 complex subunit Rieske, mitochondrial;Cytochrome b-c1 complex subunit 11;Putative cytochrome b-c1 complex subunit Rieske-like protein 1 1 45039000.0 15394000.0 17600000.0 12045000.0 True False 19927836.46110557 16620544.528356593 9852933.592136769 1.0 0.8340365779695137 0.4944306729617823 24.24828175139469 -6.959595216317131 0.44110438992795403 1.0120039865130963 0.30319828184578435 0.9997548822383628 0.003294327390344997 0.07984607773327494 0.02166825824825187 0.0044837167794618245 0.028132645884500256 1.0975006438229205e-07 6.959595216317131 -0.708805704667312 down LSDIWAK(ub)TPPITR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSDIWAKTPPITR 13 1 Q9UBM7;E9PM00;E9PJ54;E9PQ71;E9PIP9 Q9UBM7 DHCR7 7-dehydrocholesterol reductase 1 192721100.0 3377100.0 11351000.0 177993000.0 True False 3269895.809031081 15883513.49468302 131371293.62445843 1.0 4.857498349279068 40.175987645118795 21.64081323618241 -6.927675600662603 0.7656283387152507 0.41406183201862634 47.01544915580783 0.9960613951419052 1.106366005926076 0.09386292946439274 0.08372482145831558 0.9943512050040619 3.237522346461788 1.1812026138643174e-07 6.927675600662603 46.601387323789204 LSDIWAK(ub)TPPITR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSDIWAKTPPITR 13 1 Q9UBM7;E9PM00;E9PJ54;E9PQ71;E9PIP9 Q9UBM7 DHCR7 7-dehydrocholesterol reductase 1 367921600.0 4315600.0 154167000.0 209439000.0 True False 6547080.712621236 126654694.33773127 168043289.84962517 1.0 19.34521657775972 25.66690365152779 22.642420333951023 -8.771158870416734 0.5366848593695972 6.963906949655238e-18 25.662767761995706 0.9950416488854471 0.736644901739475 0.35109896536585716 0.20877842829318452 2.4934264453145145 1.2349988122483426 1.6937181035943637e-09 8.771158870416734 25.662767761995706 LSDIWAK(ub)TPPITR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSDIWAKTPPITR 13 1 Q9UBM7;E9PM00;E9PJ54;E9PQ71;E9PIP9 Q9UBM7 DHCR7 7-dehydrocholesterol reductase 1 171312500.0 3377100.0 15213000.0 152722400.0 True False 2808208.2808967764 15131044.549455943 184655947.73140597 1.0 5.388148967577283 65.75578776957303 21.421218511616686 -6.9207689878229095 0.8203622196152675 4.279234676015185e-14 75.61905529431057 0.9946398216462083 2.1631755198890237 0.09632416463986676 0.10224991813418674 1.8866249883365822 5.681685077712379 1.200137516776337e-07 6.9207689878229095 75.61905529431053 LSDIWAK(ub)TPPITR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSDIWAKTPPITR 13 1 Q9UBM7;E9PM00;E9PJ54;E9PQ71;E9PIP9 Q9UBM7 DHCR7 7-dehydrocholesterol reductase 1 295390600.0 4315600.0 120411000.0 170664000.0 True False 5586629.273193915 113710022.00022434 139604903.16051707 1.0 20.353958789754365 24.989111740486756 22.413546656043472 -8.981309667542787 0.6096077688261414 1.268385431343196e-15 24.60721965713827 0.9963170975784374 0.6305270356943488 0.4779724185518551 0.2597410010806247 2.68187634494956 0.8054857855582757 1.0439755617479681e-09 8.981309667542787 24.60721965713827 LSDLDSETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSDLDSETR 9 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 7047800.0 2163500.0 0.0 4884300.0 False True 2094820.8767400258 0.0 3604955.304140847 1.0 0.0 1.7208895252900585 20.998395457025882 -6.7491848270749895 1.6530394711513454 0.4114119894114334 1.7240642632905847 0.6453969458487474 0.4201886883440455 0.3014616983846591 1.620519091027828 0.2008300663626127 0.4879451487606793 1.7816203839595514e-07 6.7491848270749895 1.3126522738791513 LSDLGLAVEMK(ub)GGKPITQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSDLGLAVEMKGGKPITQR 19 2 Q8WTQ7 Q8WTQ7 GRK7 G protein-coupled receptor kinase 7 1 54011000.0 17330000.0 16896000.0 19785000.0 True False 22719797.823958755 14375182.660092155 17737837.99112116 1.0 0.6327161346890624 0.7807216476379047 24.437446661040493 -10.088556551676593 5.073535779700953 1.0000069669573304 0.7067188921999817 0.8396257549940614 0.06042299764362489 4.761840798056457e-06 8.554070444630197e-07 0.05850570601690064 0.01950143863303919 8.155365850832148e-11 10.088556551676593 -0.29328807475734864 LSDLGLAVEMK(ub)GGKPITQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSDLGLAVEMKGGKPITQR 19 2 Q8WTQ7 Q8WTQ7 GRK7 G protein-coupled receptor kinase 7 1 237817000.0 59500000.0 98851000.0 79466000.0 True False 90265850.03266375 81210266.72361176 63759510.26881495 1.0 0.8996787455524418 0.7063525158821728 26.427676945305915 -6.960765020345079 0.4245177266727452 1.008140989920327 0.5905432422294952 0.9997975186453506 0.0017341352108379714 0.07942900105932203 0.02013017072197842 0.0025088885748864053 0.016073555023004848 1.094548423170235e-07 6.960765020345079 -0.4175977476908319 LSDLGLAVEMK(ub)GGKPITQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSDLGLAVEMKGGKPITQR 19 2 Q8WTQ7 Q8WTQ7 GRK7 G protein-coupled receptor kinase 7 1 64750000.0 17330000.0 22609000.0 24811000.0 True False 23737369.325640608 21610059.622035064 18951152.798584763 1.0 0.9103814043408901 0.7983678620239576 24.500656722563384 -6.968110936449421 0.2998942181516511 1.019451333335431 0.6857886021226453 0.9999636666081578 0.0004971631273809775 0.07692054974846003 0.01121242173167132 0.0018593139564988955 0.010047118971627385 1.076190275810592e-07 6.968110936449421 -0.33366273121278567 LSDLGLAVEMK(ub)GGKPITQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSDLGLAVEMKGGKPITQR 19 2 Q8WTQ7 Q8WTQ7 GRK7 G protein-coupled receptor kinase 7 1 299051000.0 59500000.0 42621000.0 196930000.0 True False 77023922.92034435 40249103.88312994 161090760.6724363 1.0 0.5225532841887871 2.0914380177575627 26.198803267398365 -6.825047076044446 1.3498363550846422 0.7438850175144004 2.129557872889155 0.8956118692547039 0.21215500233902052 0.18700357619217597 0.668085292170254 0.12346084143659716 0.28425666050046533 1.4960734780291737e-07 6.825047076044446 1.3856728553747546 up LSDLLAPISEQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSDLLAPISEQIK 13 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 35064700.0 2487700.0 22230000.0 10347000.0 False True 3261398.790921066 18913370.651861306 9276391.695432432 1.0 5.799159153585109 2.8442985019972506 21.63705942822962 -9.423705255708459 9.351667960331646 0.9999754920899575 4.321728827792715 0.6275568471692781 1.20631680965273 0.0 0.0 1.1680112284712454 0.38933707615708174 3.7695954476130494e-10 9.423705255708459 3.3217533357027573 LSDLLAPISEQIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSDLLAPISEQIK 13 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 23462300.0 9588200.0 4791500.0 9082600.0 False True 9283827.83931534 6704770.9373424 6703594.587840562 1.0 0.7221989736764507 0.7220722641421726 23.14628833870315 LSDLLAPISEQIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSDLLAPISEQIK 13 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 20109600.0 2487700.0 8320500.0 9301400.0 False True 3407469.9175646864 7952872.797785971 7104600.88834614 1.0 2.3339524603844124 2.0850076626424885 21.70026948975251 -10.12701250852447 5.427901641882846 0.9999779154503856 2.2094800615138492 0.9692046298513627 0.10163128809941964 2.71629753802971e-05 4.368716988193853e-06 0.09840586016821283 0.03280135718835131 7.464272595458429e-11 10.12701250852447 1.2095021460634636 LSDLLAPISEQIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSDLLAPISEQIK 13 0 Q01518;Q01518-2;Q5T0R1;Q5T0R9;Q5T0R4;Q5T0R3;Q5T0R2;Q5T0R7;Q5T0R6;Q5T0R5 Q01518 CAP1 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 0 12507300.0 9588200.0 1534500.0 1384600.0 False True 7973013.12928089 1526233.3439255964 1674113.4583329288 1.0 0.19142491291284905 0.2099724948632967 22.926693614137427 -10.801211865267044 12.621075259940339 1.002476227281218 0.2006987038880739 0.9995963176825643 0.007572018623508653 0.0005265028214164046 8.292656227725849e-06 0.007316394901884511 0.0024438585021684532 1.5804768348234035e-11 10.801211865267044 -0.8017775233931441 LSDLSTEDDDSGHCK(ub)MNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSDLSTEDDDSGHCKMNR 18 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;S4R411;Q5T4C8 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 5123400.0 1669100.0 2363900.0 1090400.0 True False 2188206.263587392 2011215.3344100278 977575.8678553731 1.0 0.9191159754349659 0.44674758688091604 21.06131730445156 -6.936409201620889 0.6921610894873319 1.0057726447257402 0.33178175388514886 0.9976547621451676 0.011815666864682856 0.08944359833921331 0.06235937934925497 0.011209907030022212 0.041339705417307464 1.1576860453648636e-07 6.936409201620889 -0.6739908908405914 down LSDLSTEDDDSGHCK(ub)MNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSDLSTEDDDSGHCKMNR 18 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;S4R411;Q5T4C8 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 6001500.0 1669100.0 2464800.0 1867600.0 True False 2286211.3757314878 2355896.985996376 1426511.344429361 1.0 1.0304808256159568 0.623963015656389 21.12452736597445 -6.888833590851228 1.02928850826906 1.0224574662500825 0.5897913107251119 0.9801400527019144 0.026052752959230673 0.12009337892310588 0.22743173107992642 0.019315324719892862 0.047954233210547405 1.291714126485371e-07 6.888833590851228 -0.43266615552497056 LSDLSTEDDDSGHCK(ub)MNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSDLSTEDDDSGHCKMNR 18 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;S4R411;Q5T4C8 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 5468300.0 2088500.0 1892100.0 1487700.0 True False 1736680.286237574 1881906.8817475545 1798771.1916523885 1.0 1.0836231036079798 1.0357526401991533 20.72790075520106 -10.02720352507188 7.831272054768043 0.9999999985623538 1.0596878719035665 0.6745731280903269 0.019543034850366327 5.061630564468201e-10 3.6005216641970315e-11 0.01892246240942161 0.006307487375818321 9.3928302763568e-11 10.02720352507188 0.05968787334121273 LSDLSTEDDDSGHCK(ub)MNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSDLSTEDDDSGHCKMNR 18 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;S4R411;Q5T4C8 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 12559800.0 4309100.0 5218800.0 3031900.0 True False 5578214.895059757 4928369.192306107 2480125.3099210826 1.0 0.8835029279117278 0.44460913689746157 22.411372083121233 -6.946252481364542 0.598578380747989 1.0049593522612679 0.30074051825977594 0.99887337657576 0.008026524361109625 0.08502646959988416 0.042466397114223925 0.008249543928009601 0.03686649810460412 1.1317422224839695e-07 6.946252481364542 -0.7042188340014919 down LSDLVNTAILIALNKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSDLVNTAILIALNKR 16 1 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 0 23846500.0 5440000.0 6614500.0 11792000.0 False True 8252877.717272112 5434090.795675616 9461306.031382788 1.0 0.658447996182329 1.1464250841353927 22.976465833473586 -6.718514723896081 1.76439847357915 0.7918817677934425 1.1456163351345154 0.5056528546532444 0.14375254276150448 0.3581931986207521 2.178389573966169 0.06470833578546015 0.16274261803502538 1.9119885013143535e-07 6.718514723896081 0.3537345673410729 LSDLVNTAILIALNKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSDLVNTAILIALNKR 16 1 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 0 15786400.0 5440000.0 4587100.0 5759300.0 False True 7042187.238431483 4331823.852615028 4711166.495408321 1.0 0.6151247767135288 0.6689919389955963 22.747592155566036 -10.23145404899332 5.446806481446998 1.0000233179925344 0.6420583578546764 0.9832979352406619 0.021991176913895953 6.227463016055549e-06 8.787322075331981e-07 0.02129425056093875 0.007097621829236838 5.868754613393768e-11 10.23145404899332 -0.35796496013785806 LSDQCTGLQGFLVFHSFGGGTGSGFTSLLMER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSDQCTGLQGFLVFHSFGGGTGSGFTSLLMER 32 0 P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8 P68366-2 TUBA4A Tubulin alpha-4A chain 0 61797000.0 17493000.0 18877000.0 25427000.0 False True 26538159.909603126 15508251.863325816 20401342.30494998 1.0 0.5843755526438735 0.7687549692383732 24.661565005480192 -10.046001198977638 4.85331753339856 1.0000068879063395 0.6765652610537962 0.8040316429626657 0.0752725816380102 6.174648930549842e-06 1.2137909375605035e-06 0.0728840715856891 0.024294121256801308 8.994950982472807e-11 10.046001198977638 -0.3234416268525433 LSDSFSLYPQFMFHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSDSFSLYPQFMFHLR 16 0 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 0 11404100.0 5407900.0 1430700.0 4565500.0 False True 5236229.1746347975 2001985.971001935 3369658.5879358454 1.0 0.38233352747429433 0.6435277134658384 22.320096810586257 -10.365841200113522 5.895553446474992 1.0000888942621413 0.5129306204700949 0.8225859843812197 0.10663207991015036 0.00012461390563829307 1.340423389987032e-05 0.10326475909544036 0.034415355805288886 4.306840614392951e-11 10.365841200113522 -0.48715827379204646 LSDSFSLYPQFMFHLR ddPTM_RPMI8226_Bortezomib_8h_R1 2 LSDSFSLYPQFMFHLR 16 0 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 0 399865000.0 129577000.0 121983000.0 148305000.0 False True 196577782.3476044 100214180.59247091 118992451.7456093 1.0 0.5097940336678753 0.6053199416768138 27.55052503343136 -9.917770058556547 5.6087405879507095 1.0000003766260397 0.5575569876714928 0.9662196002887908 0.03899828864282334 1.8364567452577748e-07 3.551321149792329e-08 0.03775996268077911 0.012586643536560166 1.2084534932274995e-10 9.917770058556547 -0.44244338895454693 LSDSFSLYPQFMFHLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSDSFSLYPQFMFHLR 16 0 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 0 12878800.0 5407900.0 3758800.0 3712100.0 False True 4496908.460590943 3738550.5983366123 4488282.947188834 1.0 0.8313601735725183 0.998081901493504 22.100502086020533 -10.787617370007546 8.433093177490806 1.0013797468146106 0.9147210375344794 0.2586274623482685 0.06806386040692368 0.0017929551896683188 4.515456648257526e-05 0.06692167627375102 0.021967516486216813 1.630732137086444e-11 10.787617370007546 -0.0866587092801312 LSDSFSLYPQFMFHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LSDSFSLYPQFMFHLR 16 0 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 0 344275700.0 129577000.0 104825900.0 109872800.0 False True 167739980.84452862 98992246.51562819 89877077.79013078 1.0 0.5901529618474208 0.5358118996891635 27.32165135552381 -13.999999999999998 0.2847772407202889 4.429794103612968 0.5202087908169715 0.9996157919746447 0.004061430587994676 15.662603225408022 0.16912562681608215 31.375102762920232 0.02101943927614404 1.0000000000000041e-14 13.999999999999998 -3.909585312795997 LSDTK(ub)AAGEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSDTKAAGEVK 11 1 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 1 8126800.0 3046400.0 4177000.0 903400.0 True False 3993859.9013795652 3553807.8818184724 809924.8340247095 1.0 0.8898178628125916 0.2027924999935386 21.92935229541354 -6.935025919169034 0.7043149489698097 1.0087584917938306 0.04181981623481646 0.9974371267543594 0.017856238339411266 0.0901108087991204 0.06550228023931273 0.01678518355056326 0.06053851298891275 1.1613792993868899e-07 6.935025919169034 -0.9669386755590141 down LSDTK(ub)AAGEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSDTKAAGEVK 11 1 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 1 14917900.0 4871300.0 4485200.0 5561400.0 True False 4716663.247914805 6276163.750009007 4104702.5015762574 1.0 1.3306363885069903 0.8702555781125375 22.169335170847578 -6.713921576738749 1.7808993897917458 1.2024424413372858 0.871190558538194 0.48387511353994894 0.1392456504255544 0.3672361254235439 2.2726949021896834 0.06216172360963539 0.15719288114041804 1.9323172160770248e-07 6.713921576738749 -0.3312518827990918 LSDTK(ub)AAGEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSDTKAAGEVK 11 1 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 1 39753300.0 7149600.0 7259800.0 25343900.0 True False 10846465.90577365 5964231.968923705 20334667.05637402 1.0 0.5498779068441917 1.8747735191376698 23.370721711419208 -6.815045413228306 1.393313654739547 0.7561090810704212 1.9007052240002387 0.8725734040269401 0.19635751077157038 0.19999965276201992 0.7642302590707518 0.11078488181680818 0.25572226444993035 1.5309273675705624e-07 6.815045413228306 1.1445961429298175 LSDTK(ub)AAGEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSDTKAAGEVK 11 1 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 1 7407000.0 3046400.0 2905500.0 1455100.0 True False 4172736.4058644813 2777125.4027963583 1111435.3487251878 1.0 0.665540578813775 0.26635647225718484 21.992562356936432 -7.304120908385212 0.3465643966380499 1.0515553184933841 3.7093880594174835e-24 0.9997287170580094 0.004939500846747282 0.10374197986143807 0.026043524749116392 0.01231282481897628 0.05061330280935209 4.964540884746803e-08 7.304120908385212 -1.0515553184933841 down LSDTK(ub)AAGEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSDTKAAGEVK 11 1 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 1 13994600.0 4871300.0 6048900.0 3074400.0 True False 4050701.785180319 6016313.375087351 3717242.8255804903 1.0 1.4852521104116607 0.9176787190753455 21.949740446281854 -6.680309030022106 1.900588586795929 1.3069368304892017 0.9198238840321236 0.3256094672311862 0.20564709446194931 0.43784802513646837 3.058102498049241 0.0868096256596529 0.22888082226550296 2.087809983557449e-07 6.680309030022106 -0.38711294645707817 LSDTK(ub)AAGEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSDTKAAGEVK 11 1 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 1 23082100.0 7149600.0 6862400.0 9070100.0 True False 9255298.139685607 6480501.407465587 7419434.867085074 1.0 0.7001936955091674 0.801641908786431 23.141848033511657 -10.813607193892027 10.242219917290624 1.0030709063894914 0.7509178021477992 0.8893531745429092 0.04141605964105624 0.0029247184404027266 5.3225361296790547e-05 0.04038377394120464 0.013366975771278653 1.5360056249345633e-11 10.813607193892027 -0.2521531042416921 LSDTTEYQPILSSYSHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSDTTEYQPILSSYSHR 17 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 0 25545100.0 4689900.0 9095200.0 11760000.0 False True 7114921.177616625 7472090.498878061 9435630.845408885 1.0 1.0502000390932063 1.3261750355145405 22.762416343322382 -6.937713214305153 0.6805037162745273 0.9967456618818655 1.3958438716508557 0.9978488038030451 0.00665103781269197 0.08882547521086306 0.05947728348629084 0.0063671817392156995 0.024001722732756036 1.1542151904531466e-07 6.937713214305153 0.39909820976899013 LSDYLFTLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSDYLFTLAR 10 0 Q96EY8;S4R3P5 Q96EY8 MMAB Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial 0 6566700.0 2123100.0 2476200.0 1967400.0 False True 2783404.6601296435 2106760.612152002 1763832.320633399 1.0 0.7569005837814019 0.6336959716634392 21.40841923678737 -13.999999999594047 0.08756478391581675 2.258607829538712 0.31222726625731634 0.9998536872187546 0.0018408748270282954 12.185917051784564 0.08537318663256223 2.879749806723217 0.2894974974746265 1.0000000009347404e-14 13.999999999594047 -1.9463805632813957 LSDYLFTLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSDYLFTLAR 10 0 Q96EY8;S4R3P5 Q96EY8 MMAB Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial 0 5723500.0 2408500.0 0.0 3315000.0 False True 2332043.4858462457 0.0 2446702.0521317124 1.0 0.0 1.0491665644235875 21.15316326019097 -10.512990613413109 5.0315492182284665 1.0016852438504753 0.5245832822117814 0.21493392224124974 0.4283204563378182 0.008122785781514905 0.0007862133228670452 0.41602979481046476 0.13823983285302124 3.069088321154024e-11 10.512990613413109 -0.4771019616386939 LSDYLFTLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSDYLFTLAR 10 0 Q96EY8;S4R3P5 Q96EY8 MMAB Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial 0 6731100.0 2123100.0 2520700.0 2087300.0 False True 2908067.4446201655 2409327.1391597944 1594322.7292928924 1.0 0.8284976827538766 0.5482413182136955 21.471629298310262 -6.963795122567613 0.3781646044774402 1.0196526188277495 0.34720465723571536 0.9998861075309764 0.001987153185781247 0.07837227959158365 0.016316660093863226 0.0036544548141149956 0.023702460313460575 1.0869382633386118e-07 6.963795122567613 -0.6724479615920341 LSDYLFTLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSDYLFTLAR 10 0 Q96EY8;S4R3P5 Q96EY8 MMAB Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial 0 4391600.0 2408500.0 1983100.0 0.0 False True 2002774.464641226 1972416.6466854715 0.0 1.0 0.9848421185252166 0.0 20.933568535625245 -7.035414143076767 1.0706323605132928 1.0173775273975358 1.72222201075039e-18 0.9869048753151819 0.05354051206062112 0.08646478385369773 0.19172570896864646 0.04205959633718892 0.07577799655708212 9.216920826796678e-08 7.035414143076767 -1.0173775273975358 down LSECEEQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSECEEQAK 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 4018470.0 1867600.0 784670.0 1366200.0 False True 1808314.060272555 1097992.8229999929 1008351.2348785338 1.0 0.6071914426382881 0.5576195291688169 20.786213829958818 -13.999999999999998 0.29186943484653705 4.420733820701889 0.5443636613259577 0.9996316465648821 0.003798073086388949 16.077832734215857 0.1713650784804576 33.0586508947831 0.018565363718462943 1.0000000000000041e-14 13.999999999999998 -3.876370159375931 LSECEEQAK(ub)AAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSECEEQAKAAK 12 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 8154900.0 2087100.0 3684100.0 2383700.0 True False 2736208.311505149 3134446.640509325 2137057.590064979 1.0 1.1455438635025237 0.7810288350777702 21.383746638193912 -6.798336997040409 1.4625902860343183 1.0804721414098544 0.7761948616994764 0.8272976306480243 0.062259605431010986 0.22313181040586447 0.9424889788865809 0.033490290156457415 0.07796984612510133 1.5909737090496498e-07 6.798336997040409 -0.304277279710378 LSECEEQAK(ub)AAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSECEEQAKAAK 12 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 6552400.0 2921400.0 1713500.0 1917500.0 True False 2828661.7560935095 2397709.485784457 1415249.226233049 1.0 0.8476480019639343 0.5003246581830847 21.43168824270691 -6.957406279802614 0.4705651960307714 1.0091235610849096 0.3245969756880158 0.9996615771301299 0.00384672871361595 0.08064099313590688 0.024655854651660872 0.004807424499070352 0.02866536030845403 1.10304624414544e-07 6.957406279802614 -0.6845265853968938 LSECEEQAK(ub)AAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSECEEQAKAAK 12 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 30102600.0 4141800.0 4673800.0 21287000.0 True False 6283413.406139269 3839723.8734339224 17079615.119576454 1.0 0.6110888501594187 2.7182064931281866 22.583117072114923 -6.859052953851294 1.1905662173787577 0.7895130340031759 2.8183874376798466 0.9524758543771368 0.19958152744716334 0.14777723841606702 0.3985743753090253 0.1308008770727762 0.30499922456694467 1.3833976899718432e-07 6.859052953851294 2.028874403676671 up LSECEEQAK(ub)AAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSECEEQAKAAK 12 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 8368000.0 2087100.0 2705000.0 3575900.0 True False 2858757.2717567473 2585484.155761196 2731346.0679722396 1.0 0.9044084229551881 0.9554312620230917 21.446956699716804 -10.091783641051228 4.153484659917213 1.000010870662768 0.9299198424731665 0.7155338538382516 0.020829986890259066 29008496.29701661 7256.736244860704 3284.394366257133 0.007130658548714856 8.094990789507555e-11 10.091783641051228 -0.07009102818960145 LSECEEQAK(ub)AAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSECEEQAKAAK 12 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 7593200.0 2921400.0 2210100.0 2461700.0 True False 2429273.5399638256 2198193.7526294966 2976430.088385214 1.0 0.9048769998384908 1.2252346388416746 21.212093518141188 -6.8271459826406895 1.3405753020382074 0.9490634824924918 1.233365798525519 0.9000535365910067 0.042468431953212905 0.1843586368937649 0.6489632959753026 0.024880099023426572 0.05726839479373898 1.4888605318035434e-07 6.8271459826406895 0.28430231603302725 LSECEEQAK(ub)AAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSECEEQAKAAK 12 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 28166000.0 4141800.0 5366200.0 18658000.0 True False 5361641.747083732 5067566.252731095 15262435.447246796 1.0 0.945151968702014 2.846597398184658 22.354243394207373 -6.900256907712492 0.9596284946550621 0.9215011626801258 3.047240469908745 0.986694088171863 0.10193658309777563 0.1112168909521151 0.17634929393308657 0.07962973276509842 0.20745443780623746 1.2581809123405475e-07 6.900256907712492 2.1257393072286193 up LSEDYGVLK(ub)TDEGIAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSEDYGVLKTDEGIAYR 17 1 P32119 P32119 PRDX2 Peroxiredoxin-2 1 17148300.0 6273500.0 9240400.0 1634400.0 True False 8224619.252660425 7861768.338797085 1465287.9662718466 1.0 0.9558823451011463 0.17815875984749913 22.97151746215223 -6.918575769752893 0.8352279157238045 1.0180569107510198 0.05676479071686329 0.9937758845199013 0.029778265762780337 0.09901719625999036 0.11001230482017806 0.025465318642934335 0.07527174537353513 1.206213626205663e-07 6.918575769752893 -0.9612921200341565 down LSEDYGVLK(ub)TDEGIAYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSEDYGVLKTDEGIAYR 17 1 P32119 P32119 PRDX2 Peroxiredoxin-2 1 41771000.0 10577000.0 17422000.0 13772000.0 True False 10241238.924557077 24378695.454529747 10164700.048856087 1.0 2.380443971097384 0.9925264046406085 23.287886918826423 -6.647382455593278 2.0181681292819422 1.8975726720085622 0.998362467358231 0.18366057834150773 0.5895582031873309 0.5147752997813373 4.015909746463035 0.23718158712378815 0.6528338692010068 2.2522549205627776e-07 6.647382455593278 -0.8992102046503312 LSEDYGVLK(ub)TDEGIAYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSEDYGVLKTDEGIAYR 17 1 P32119 P32119 PRDX2 Peroxiredoxin-2 1 61577000.0 23308000.0 21189000.0 17080000.0 True False 35359940.04304749 17407657.39958737 13704130.51357007 1.0 0.49229883813137526 0.38756090923475967 25.075612492683206 -13.999999999999998 0.22187113348405033 4.089060547052606 0.3325310424846725 0.999499836458707 0.005981555555067878 13.051189061902354 0.14920493077019806 17.68146118230045 0.05725746475749171 1.0000000000000041e-14 13.999999999999998 -3.756529504567933 LSEDYGVLK(ub)TDEGIAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSEDYGVLKTDEGIAYR 17 1 P32119 P32119 PRDX2 Peroxiredoxin-2 1 25289000.0 6273500.0 8711500.0 10304000.0 True False 8592982.484962856 8326597.124921865 7870407.417541295 1.0 0.9689996621653602 0.9159110275523057 23.034727523675123 -6.962967736697459 0.39145574835911157 1.0032081068266434 0.8797908869236475 0.9998647524771535 0.00040375831201944337 0.07865865368665102 0.01734191552052887 0.0006849026584327687 0.0044629404833886645 1.08901099186547e-07 6.962967736697459 -0.12341721990299592 LSEDYGVLK(ub)TDEGIAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSEDYGVLKTDEGIAYR 17 1 P32119 P32119 PRDX2 Peroxiredoxin-2 1 28799700.0 10577000.0 10974000.0 7248700.0 True False 8795244.140548155 10914880.88383154 8764369.655797996 1.0 1.2409980563826943 0.9964896386891843 23.0682921942607 -6.6495309250161885 2.010547172855634 1.1564476046423156 0.9975249709711662 0.1919771476906913 0.10287376807812534 0.5097106647514866 3.9489173294458313 0.04150787226910205 0.11391937592186303 2.241140454133412e-07 6.6495309250161885 -0.15892263367114934 LSEDYGVLK(ub)TDEGIAYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSEDYGVLKTDEGIAYR 17 1 P32119 P32119 PRDX2 Peroxiredoxin-2 1 57998000.0 23308000.0 20254000.0 14436000.0 True False 30172665.469367817 19126847.095303077 11808796.125868514 1.0 0.6339130732324998 0.39137397847257327 24.846738814775655 -8.316365634820693 0.16679741090537584 1.3563628018370366 2.1323543237471056e-09 0.9998795649461889 0.0027454449376130806 0.0953455499435341 0.036766540147444536 0.13157702027228643 0.1293911272177041 4.826522834292057e-09 8.316365634820693 -1.3563627997046823 down LSEELSGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSEELSGGR 9 0 P61158;B4DXW1;Q9P1U1-2;Q9P1U1 P61158;Q9P1U1-2 ACTR3;ACTR3B Actin-related protein 3;Actin-related protein 3B 0 4344120.0 274920.0 2181600.0 1887600.0 False True 360422.78232906695 1856113.783810197 1692289.2591377492 1.0 5.149823692653147 4.695289371559994 18.459330681244065 -10.18984232240635 4.786240194510986 0.9994800519535216 4.922556532121946 0.9900297863315529 0.18556285959633043 5888493.022844346 12536808.25773956 21582.36505491828 0.06352310396271842 6.458886867417013e-11 10.18984232240635 3.923076480168424 LSEELSGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSEELSGGR 9 0 P61158;B4DXW1;Q9P1U1-2;Q9P1U1 P61158;Q9P1U1-2 ACTR3;ACTR3B Actin-related protein 3;Actin-related protein 3B 0 4289120.0 274920.0 1954900.0 2059300.0 False True 376565.35343364713 1868526.054010189 1572935.75261479 1.0 4.962023290173543 4.17705914331269 18.522540742766957 -10.245139385046949 5.134065756141563 0.9995245477141048 4.569541216744356 0.9650003599028201 0.32046027103570235 0.001744173285940693 0.00025644392132421676 0.3103156394276485 0.10342810773624328 5.6867038910476527e-11 10.245139385046949 3.570016669030251 LSEGDLLAEIETDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSEGDLLAEIETDK 14 0 P10515 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial 0 13793100.0 4004700.0 2879100.0 6909300.0 False True 3877572.9905619496 4028739.6443081563 5099547.055443021 1.0 1.0389848634994487 1.315138894317494 21.886722507808145 -6.93243108144082 0.7265515839276825 0.9961561905786259 1.3755107610489705 0.9969950180077914 0.007689546669834974 0.09139468755908106 0.07163694493755032 0.00710977834237311 0.024661576269017924 1.1683391198756018e-07 6.93243108144082 0.3793545704703446 LSEGDLLAEIETDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSEGDLLAEIETDK 14 0 P10515 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial 0 10604500.0 4004700.0 2910800.0 3689000.0 False True 3330085.488290934 2895118.9426514343 4460352.843991169 1.0 0.8693827689502551 1.3394109129253347 21.66712778324242 -6.832578838688998 1.3164971133530214 0.9303241891686431 1.3527247638941937 0.9109071026899086 0.059129293756108 0.1776515893060798 0.6012769776319179 0.03525638346764973 0.0811281493921091 1.470351474170557e-07 6.832578838688998 0.4224005747255506 LSEGFSIHTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSEGFSIHTR 10 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 35619800.0 9575700.0 7379200.0 18664900.0 False True 12553835.431210713 6278252.12389632 16733635.194363307 1.0 0.500106294868869 1.3329500204185396 23.58162486601541 -6.744170729135505 1.6715344315354963 0.7040103237738948 1.3338860155782002 0.6234793019433822 0.21002517823635744 0.310317550240966 1.7039559090354794 0.09934064702040839 0.24265579091100792 1.802309080780758e-07 6.744170729135505 0.6298756918043054 LSEGFSIHTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSEGFSIHTR 10 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 25947700.0 7267200.0 2406000.0 16274500.0 False True 7036506.713864161 3366728.3471242497 12011720.225465309 1.0 0.4784658757577424 1.70705731038363 22.746427947423516 -6.791382671422173 1.4908989367608365 0.7090343749393111 1.7206072419696212 0.805731905191189 0.221909989828372 0.2333045423694457 1.0244606957814324 0.1171496692895548 0.27399115474764824 1.6166549210476617e-07 6.791382671422173 1.0115728670303101 LSEGFSIHTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSEGFSIHTR 10 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 47702700.0 3919400.0 35158000.0 8625300.0 False True 5946016.346521378 28883780.209292248 6920505.674396705 1.0 4.857669156289865 1.1638894464939433 22.503491998767664 -6.636017946194577 2.058813199733814 3.530273251274123 1.179101624755828 0.1395186678497069 1.652233360397401 0.5434902252696663 4.397791338089537 0.6546461640881023 1.8296826179514445 2.3119692515283311e-07 6.636017946194577 -2.351171626518295 LSEGFSIHTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSEGFSIHTR 10 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 21052800.0 9575700.0 5482400.0 5994700.0 False True 13116095.06356241 5240169.440127602 4578875.324721936 1.0 0.39952206923882577 0.3491035481621682 23.6448349275383 -13.999999999999998 0.35093698293159786 8.427348179555972 0.3422239600486317 0.9997564903793545 0.004613852060954734 20.753642092294175 0.1907670590458981 114.9609199175497 0.014995161809283376 1.0000000000000041e-14 13.999999999999998 -8.08512421950734 LSEGFSIHTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSEGFSIHTR 10 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 15620500.0 7267200.0 5566400.0 2786900.0 False True 6042998.791546902 5536412.6983561115 3369627.904830299 1.0 0.9161697510349637 0.5576085683723483 22.526833222857793 -6.943337860234179 0.6277419623293953 1.003911833041088 0.4506166123018009 0.9985692359177063 0.00725731273898738 0.08627631477724723 0.047919047909959746 0.007257893839455456 0.03043613807375263 1.139363072983676e-07 6.943337860234179 -0.5532952207392872 LSEGFSIHTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSEGFSIHTR 10 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 22101400.0 3919400.0 12267000.0 5915000.0 False True 5073740.5629243255 11584330.666440366 4838530.693025236 1.0 2.2831933408442873 0.9536417231070399 22.274618320860114 -6.6542794701382615 1.9936911877300247 1.8298438564624095 0.9592707270328413 0.21146685875380078 0.5471113577750376 0.4980915518676428 3.7997452596753516 0.22221080847062602 0.6060030115581008 2.2167694612078052e-07 6.6542794701382615 -0.8705731294295682 LSEIDVSSEGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSEIDVSSEGVK 12 0 Q96C19;H0Y4Y4 Q96C19 EFHD2 EF-hand domain-containing protein D2 0 7399600.0 1506100.0 3055800.0 2837700.0 False True 1974511.6850931463 2599886.5514151044 2544082.025140488 1.0 1.316723811281196 1.2884613671052916 20.913064474967992 -10.061812256382185 4.488354514999808 0.9999818047237741 1.3025925891921484 0.9934997211545218 0.011538094590539474 8001144.073178528 0.2775969984671108 1539.5437811097017 0.003949796663009441 8.673367406311429e-11 10.061812256382185 0.3026107844683743 LSEIDVSSEGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSEIDVSSEGVK 12 0 Q96C19;H0Y4Y4 Q96C19 EFHD2 EF-hand domain-containing protein D2 0 5579900.0 1506100.0 4073800.0 0.0 False True 2062945.8708221156 3893806.0457448973 0.0 1.0 1.8874979226639408 0.0 20.976274536490884 -6.786817887908118 1.5612338162637036 1.5028719765667045 2.3698194171639843e-18 0.7629417780886528 0.3754009463372284 0.24705958131023623 1.1979521132153406 0.19086285560037158 0.43828178844363536 1.6337368768569225e-07 6.786817887908118 -1.5028719765667045 LSELK(ub)ETVELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSELKETVELK 11 1 Q08379;Q08379-2;A0A1W2PQY5 Q08379 GOLGA2 Golgin subfamily A member 2 1 13133400.0 2133500.0 5005300.0 5994600.0 True False 2761857.807572345 4726750.65498769 4903644.309790214 1.0 1.7114388155784432 1.7754876070540668 21.397207614629444 -11.261976783436577 0.4152026671890201 5.422527617690955e-12 1.7788002732012937 0.9996455962344865 0.006616183977746133 3.3728599890292235 0.20553202531242848 3.120731451118994 0.015708511724628813 5.47045206116683e-12 11.261976783436577 1.7788002731958712 LSELLPEEVEAEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSELLPEEVEAEVK 14 0 Q9Y2X3;H7BZ72 Q9Y2X3 NOP58 Nucleolar protein 58 0 10576400.0 3668800.0 2063100.0 4844500.0 False True 3552335.9521995834 2886906.588924373 3575580.118115257 1.0 0.8126783693239428 1.0065433467522353 21.76033659629742 -11.125620800449237 9.9698632908397 2.616361408972445 0.9096108580365563 0.2247157470914799 0.07914504561591583 0.0408567988226202 0.000514798689043879 0.00110108716022845 0.025543953633772366 7.488230419296835e-12 11.125620800449237 -1.706750550935889 LSELLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSELLR 6 0 P08238;P07900;P07900-2;A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 P08238;P07900;A0A669KB10 HSP90AB1;HSP90AA1;GBF1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 0 50803000.0 6018000.0 27441000.0 17344000.0 False True 7889656.278394905 23346909.764180213 15549409.255395785 1.0 2.9591795815127675 1.9708601625620126 22.911531018326297 -9.935620049032112 5.544527367326386 0.9999981623297164 2.4650198720405356 0.7455311253681959 0.40347971322996745 9.167789814585247e-06 1.7596975339794876e-06 0.39066804123842 0.1302225174877418 1.1597915786371157e-10 9.935620049032112 1.4650217097108191 LSELLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSELLR 6 0 P08238;P07900;P07900-2;A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 P08238;P07900;A0A669KB10 HSP90AB1;HSP90AA1;GBF1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 0 41539100.0 23350000.0 4627100.0 13562000.0 False True 22608767.031143796 6474725.160007728 10009705.348721044 1.0 0.2863811702375778 0.4427355695661147 24.430378981088378 -10.233350988560742 8.181959639275009 1.0000003391441903 0.36455836991385443 0.9565645397316263 0.06383141623237935 3.9499209830503764e-07 3.691961882597842e-08 0.06180453616018973 0.020601501002736604 5.843176588215487e-11 10.233350988560742 -0.6354419692303359 LSELLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSELLR 6 0 P08238;P07900;P07900-2;A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 P08238;P07900;A0A669KB10 HSP90AB1;HSP90AA1;GBF1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 0 221862100.0 6537000.0 211800000.0 3525100.0 False True 9917106.918714667 174002635.1990468 2828362.439893782 1.0 17.54570527728049 0.28520035763215906 23.241487879172947 -6.556563664991889 2.360148463861363 9.999999999999998 0.3097902688304562 0.275322928095171 6.78771408284895 0.5312615025574224 5.543100834022618 2.644325842735815 8.245737975184372 2.7761078553499887e-07 6.556563664991889 -9.690209731169542 LSELLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSELLR 6 0 P08238;P07900;P07900-2;A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 P08238;P07900;A0A669KB10 HSP90AB1;HSP90AA1;GBF1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 0 62507000.0 6018000.0 37263000.0 19226000.0 False True 8243017.230334974 35616597.44773735 14685214.771899177 1.0 4.320820453542833 1.7815339167139421 22.97474107984919 -6.578179930168388 2.2743321823307703 3.2638563928303563 1.787663646520171 0.0 1.4433250794762162 0.7047478371760747 6.854209852904237 0.5335217269522599 1.6139116704001553 2.641314222171913e-07 6.578179930168388 -1.4761927463101854 LSELLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSELLR 6 0 P08238;P07900;P07900-2;A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 P08238;P07900;A0A669KB10 HSP90AB1;HSP90AA1;GBF1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 0 26051400.0 23350000.0 1519100.0 1182300.0 False True 19416559.580391377 1510916.3067822575 1429513.4636624441 1.0 0.0778158612768927 0.07362341704995451 24.210784256522654 LSELLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSELLR 6 0 P08238;P07900;P07900-2;A0A669KB10;A0A669KBG8;Q92538-3;Q92538-2;Q92538 P08238;P07900;A0A669KB10 HSP90AB1;HSP90AA1;GBF1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 0 18980500.0 6537000.0 5158600.0 7284900.0 False True 8462275.3635343 4871519.375226152 5959122.949386234 1.0 0.5756748824575645 0.7041986573806533 23.012614201265396 -10.666075685222937 9.924852902777012 1.0001746743228577 0.6399367699191104 0.9127762050425504 0.052469611396313336 0.00020289291884062003 6.82637222711168e-06 0.05082731859230899 0.01693449425999137 2.157368408203583e-11 10.666075685222937 -0.36023790440374726 LSELSNSQQSVQTLSLWLIHHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSELSNSQQSVQTLSLWLIHHR 22 0 Q9NQG5;E9PIQ9;E9PQF3;Q96P16;A0A0C4DGQ6;K7EQR8 Q9NQG5;Q96P16 RPRD1B;RPRD1A Regulation of nuclear pre-mRNA domain-containing protein 1B;Regulation of nuclear pre-mRNA domain-containing protein 1A 0 76868000.0 15644000.0 39168000.0 22056000.0 False True 20251466.38934227 36988266.368560895 18042034.313671093 1.0 1.8264487942476448 0.890900143565212 24.271523040161277 -6.673558697715891 1.9250578356404953 1.5259143832618218 0.8946460422719142 0.2947322372657858 0.3507755626048583 0.45302456014690373 3.240036641338646 0.1465280945392074 0.3896360530128254 2.1205147723968984e-07 6.673558697715891 -0.6312683409899076 LSEPEEELLQQFK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSEPEEELLQQFKR 14 1 Q9Y2U8 Q9Y2U8 LEMD3 Inner nuclear membrane protein Man1 1 8300000.0 2897700.0 1925900.0 3476400.0 True False 2409565.9398758044 1915524.794438783 4203299.166942504 1.0 0.7949667459764619 1.7444217223452094 21.200341851551748 -6.850188549963238 1.2342445943892564 0.8905727300609536 1.7825016249093781 0.9405702352784833 0.09944624589034323 0.15725075551299647 0.4608890933993961 0.06304622979915024 0.14590472936266047 1.4119244212540969e-07 6.850188549963238 0.8919288948484245 LSEVTFRPLFFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSEVTFRPLFFK 12 1 Q9H583;Q5T3Q7 Q9H583 HEATR1 HEAT repeat-containing protein 1;HEAT repeat-containing protein 1, N-terminally processed 0 3821100.0 1474800.0 1404400.0 941900.0 False True 1933477.0819835167 1194868.9943083227 844441.2233427879 1.0 0.6179897374746898 0.436747469732867 20.882766233199415 -13.999999999975012 0.09907213978794731 2.8918197247398423 0.04510736053693931 0.9997983569302753 0.0033336920000124975 12.08754546891768 0.09354786957214133 4.686525083294458 0.3494813448789651 1.000000000057537e-14 13.999999999975012 -2.846712364202903 LSEVTFRPLFFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSEVTFRPLFFK 12 1 Q9H583;Q5T3Q7 Q9H583 HEATR1 HEAT repeat-containing protein 1;HEAT repeat-containing protein 1, N-terminally processed 0 3795430.0 1474800.0 769030.0 1551600.0 False True 2020073.414971422 735051.7117578682 1185144.0362050736 1.0 0.3638737613742949 0.5866836459613721 20.945976294722307 -10.308794932919287 5.2372846501155585 1.0001258602241951 0.4752787036678317 0.8808788267968053 0.09096175448129834 0.0001337089924908868 1.764673340673413e-05 0.08809425927162627 0.029357780020631368 4.9113972992964834e-11 10.308794932919287 -0.5248471565563635 LSFATCK(ub)S ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSFATCKS 8 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 40083300.0 14312000.0 18542000.0 7229300.0 True False 18763170.597605154 15775605.87614993 6481281.3843423035 1.0 0.8407750595287694 0.34542570247533455 24.161400299044868 -6.9506314035595445 0.5518723141328392 1.0067757311090042 0.1560795528518525 0.9992498792769876 0.007633823982150907 0.08323326803250151 0.03492128862725009 0.0082657804321723 0.04110811467430928 1.1203883813128301e-07 6.9506314035595445 -0.8506961782571517 down LSFATCK(ub)S ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSFATCKS 8 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 29739600.0 13702000.0 11031000.0 5006600.0 True False 13267037.510095617 15435735.825905051 3695221.2652194966 1.0 1.1634651529521307 0.27852648056565754 23.6613429213823 -6.859014259145705 1.1907782164144034 1.0884623439467684 0.23648825708501386 0.9524238620064275 0.08386063495316283 0.14781999797909223 0.39885618699506253 0.05495134146856113 0.12812780651233782 1.3835209532260152e-07 6.859014259145705 -0.8519740868617546 down LSFATCK(ub)S ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSFATCKS 8 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 46882600.0 33223000.0 6465300.0 7194300.0 True False 50401719.92664176 5311516.7013805425 5772343.451626293 1.0 0.10538363986608593 0.11452671575548952 25.58696962982759 -10.083293905186752 5.0285402574059885 1.0000217237987061 0.1099551778075298 0.9999208613153686 0.003732645114446562 8291970.9401470255 4156791.4603043413 1907.2697697885935 0.001277784349546793 8.254791243609484e-11 10.083293905186752 -0.8900665459911763 LSFATCK(ub)S ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSFATCKS 8 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 35781400.0 14312000.0 12358000.0 9111400.0 True False 19603533.167257242 11811982.697558904 6959474.975173306 1.0 0.6025435617538497 0.35501125821529733 24.22461036056776 -8.642012015536904 0.17299362321835907 1.3904194332340045 2.6047241343596772e-20 0.9998060704094451 0.0036997644646716574 0.225997681437863 0.046971049858728804 0.18676452176252253 0.14253261986228358 2.2802789831138734e-09 8.642012015536904 -1.3904194332340045 down LSFATCK(ub)S ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSFATCKS 8 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 35439200.0 13702000.0 16181000.0 5556200.0 True False 11393820.101521324 16093829.741322972 6717975.731033806 1.0 1.412505164898478 0.5896157453053703 23.441748196816576 -6.770436461485456 1.5730482913020323 1.2364712542952137 0.5849397158121683 0.7321395227010723 0.17386839816093153 0.2657208645051225 1.2977444824656874 0.08712392759981118 0.20728572726304142 1.6965377923953e-07 6.770436461485456 -0.6515315384830453 LSFATCK(ub)S ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSFATCKS 8 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 51796100.0 33223000.0 11383000.0 7190100.0 True False 43007828.423236944 10749526.043538816 5881575.576656085 1.0 0.24994347395905472 0.1367559300780296 25.35809595192004 -13.999999999999998 0.26626547101397285 6.674874718238747 0.09780378399762008 0.9995753630741856 0.007893524120033012 14.703340564771603 0.1633195183249899 45.06552699539392 0.04790338371078546 1.0000000000000041e-14 13.999999999999998 -6.577070934241126 LSFAVPFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSFAVPFR 8 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 18195400.0 3821500.0 4708900.0 9665000.0 False True 5010023.507458644 4006350.4751484394 8664958.5132265 1.0 0.7996670013990969 1.7295245222555526 22.256385942009018 -6.8503159105587885 1.2334693935748942 0.8930600894851719 1.7669431679685113 0.9407751140912176 0.09724233276348278 0.157111224381022 0.4598125619661798 0.061682314132119706 0.1427739597248245 1.4115104229699073e-07 6.8503159105587885 0.8738830784833393 LSFAVPFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSFAVPFR 8 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 9174330.0 2267000.0 967930.0 5939400.0 False True 2195035.325893062 1354429.4966882674 4383692.961819328 1.0 0.6170422319454975 1.9970944932450228 21.065812727344777 -6.832672391832643 1.3158693429010835 0.7957174657725854 2.0363140477338373 0.911121748613211 0.17341974691599174 0.17753876309852604 0.6002547958480438 0.10344532882048148 0.2380639017620442 1.470034773881427e-07 6.832672391832643 1.2405965819612519 LSFAVPFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSFAVPFR 8 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 12323100.0 3821500.0 3391800.0 5109800.0 False True 5234411.822154386 3241939.060817307 3902970.4796343697 1.0 0.6193511651291864 0.7456368761653874 22.31959600353191 -10.91944091160427 11.141884827496423 1.0401949806321704 0.6824940206472869 0.8939350600998685 0.05155592564054246 0.028124843434862046 0.00020335053213386606 0.02727364833691705 0.016639603450344074 1.203813164724855e-11 10.91944091160427 -0.3577009599848835 LSFAVPFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSFAVPFR 8 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 8564800.0 2267000.0 2791700.0 3506100.0 False True 1885110.9451283624 2776660.557990933 4239209.299625222 1.0 1.4729427809894033 2.248785043968095 20.846218002779054 -6.963727399192391 0.379265085815434 0.9462647921822734 2.8028665779771216 0.999884452896814 0.005533610935804904 0.07839556837367918 0.016399604392061652 0.010104597669097338 0.06558110715872402 1.087107772440464e-07 6.963727399192391 1.8566017857948482 LSFDK(ub)DAMVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSFDKDAMVAR 11 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 13557000.0 2637800.0 3470200.0 7449000.0 True False 2554064.482858719 4855868.956853936 5497883.434790076 1.0 1.90123193421446 2.152601655787638 21.28436351876815 -10.6206693567546 0.26464859354589687 1.443716754768598e-14 2.2638101142001963 0.999144848233987 0.014470911529725504 2.302552096249067 0.13252396352190068 1.6038869427805291 0.10605967371787976 2.395138563355776e-11 10.6206693567546 2.2638101142001816 LSFDK(ub)DAMVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSFDKDAMVAR 11 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 20093500.0 4715600.0 5435800.0 9942100.0 True False 7153909.956538309 4465739.019900748 7977039.57722276 1.0 0.6242375214436813 1.1150601035916243 22.770300529134364 -6.7021510880750705 1.8233147517224766 0.7671557516180324 1.1136537996021965 0.42770810809805015 0.15855305321094798 0.39108149778513046 2.5291547802014014 0.06933662189558577 0.17783583549803633 1.9854040887158348e-07 6.7021510880750705 0.34649804798416406 LSFDKDAMVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSFDKDAMVAR 11 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 6077920.0 2141400.0 452920.0 3483600.0 False True 2073422.429143099 633773.3179465985 2571140.654240131 1.0 0.3056653140424083 1.240046706402577 20.98358264348681 -6.707718615631874 1.8033893448054268 0.5721473631948598 1.2377029362542855 0.45424771170767975 0.29269519284765666 0.37967390863257283 2.4055596995524473 0.12923085091038955 0.3292121435148466 1.96011424264134e-07 6.707718615631874 0.6655555730594257 LSFFFDFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSFFFDFR 8 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 163302000.0 45764000.0 55117000.0 62421000.0 False True 69427333.79655157 45280940.718913496 50083461.98990376 1.0 0.6522062456208362 0.7213795957751641 26.04900043319654 -10.805086273255297 7.162712228213951 1.0125811585572115 0.6867929206980001 0.9647083628991736 0.028239901946162563 0.00565825212354426 0.00015397375915610306 0.027268919890440328 0.009114389161334835 1.5664398635516674e-11 10.805086273255297 -0.3257882378592114 LSFFFDFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSFFFDFR 8 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 88934000.0 45764000.0 13181000.0 29989000.0 False True 59242400.14330478 12447465.76296979 24531309.71312492 1.0 0.2101107607534454 0.41408365720809337 25.82012675528899 -10.292111216156089 5.136164726086312 1.000159108605687 0.31209720898795296 0.9381386922604266 0.0832715862790467 0.0001517504318283749 2.091484818806473e-05 0.08064572490304532 0.02687578890585038 5.103742842123369e-11 10.292111216156089 -0.6880618996177339 LSFFFDGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSFFFDGTK 9 0 Q8NCF5;H3BSZ7;Q8NCF5-3;Q8NCF5-2 Q8NCF5 NFATC2IP NFATC2-interacting protein 0 2574400.0 2574400.0 0.0 0.0 False True 2492677.081155315 0.0 0.0 1.0 0.0 0.0 21.249264567440076 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 LSFFFDGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSFFFDGTK 9 0 Q8NCF5;H3BSZ7;Q8NCF5-3;Q8NCF5-2 Q8NCF5 NFATC2IP NFATC2-interacting protein 0 7997000.0 2256400.0 1675200.0 4065400.0 False True 3090652.056917221 1601184.1248544024 3105236.2495411877 1.0 0.5180732400047348 1.0047188076675684 21.559479815233352 -10.803800221894445 10.9231535448993 1.0017161584163061 0.7613960238361519 0.24272823986506054 0.19867222106016802 0.008347372924195877 0.000149933735524995 0.19338725197585038 0.06412118362667239 1.571085346957796e-11 10.803800221894445 -0.24032013458015422 LSFFFDGTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSFFFDGTK 9 0 Q8NCF5;H3BSZ7;Q8NCF5-3;Q8NCF5-2 Q8NCF5 NFATC2IP NFATC2-interacting protein 0 3770800.0 2574400.0 1196400.0 0.0 False True 2140727.665257369 1189954.7557331922 0.0 1.0 0.5558646132552922 0.0 21.029669842874352 -7.766422209917418 0.6293748644890421 1.0029979631107693 2.7497513887875933e-19 0.9878465091797412 0.04510000554270269 0.118113690082953 0.1541844355923837 0.04316596551139689 0.07792362608592956 1.7122918520156194e-08 7.766422209917418 -1.0029979631107693 down LSFHQTQVSQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSFHQTQVSQR 11 0 Q969Z0;C9IZN7 Q969Z0 TBRG4 Protein TBRG4 0 3048910.0 579010.0 1278400.0 1191500.0 False True 759087.7171408169 1087667.7031641707 1068215.0096750522 1.0 1.4328616819950462 1.4072352714368712 19.533907081779823 -10.168652984953553 4.8695147036762165 0.9999624136175014 1.4200484767173178 0.9972162676163085 0.01046193830582041 4.269546321853466e-06 7.288908309025768e-07 0.010130632710665968 0.0033765760682851714 6.781831810164752e-11 10.168652984953553 0.42008606309981644 LSFHQTQVSQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSFHQTQVSQR 11 0 Q969Z0;C9IZN7 Q969Z0 TBRG4 Protein TBRG4 0 2645410.0 579010.0 1024900.0 1041500.0 False True 793085.6441569051 979616.5291089269 795519.1503658058 1.0 1.2351963956557486 1.0030684027971375 19.597117143302714 -10.889085648618767 2.7645909613770896 0.9412232944341244 1.1191323990774522 0.2599122060615342 0.09476585753311452 71681121.634728 29325466.95279121 27259166.348119676 0.03468075189471132 1.2909646531944027e-11 10.889085648618767 0.17790910464332776 LSFLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSFLLR 6 0 Q96T58;Q8NFU1 Q96T58 SPEN;BEST2 Msx2-interacting protein;Bestrophin-2 0 2486270.0 1006600.0 631260.0 848410.0 False True 1319662.3479282674 537078.4686322076 760624.6717233817 1.0 0.4069817324676762 0.5763782477521491 20.3317374146025 -10.810344337241181 10.796136357958652 1.0045560534426983 0.49167999011006336 0.9231133677164259 0.06915583777542168 0.007554888654333158 0.00013271641910096358 0.0667043811410578 0.022319950666435842 1.5475891018796278e-11 10.810344337241181 -0.5128760633326349 LSFLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSFLLR 6 0 Q96T58;Q8NFU1 Q96T58 SPEN;BEST2 Msx2-interacting protein;Bestrophin-2 0 3225680.0 1006600.0 889080.0 1330000.0 False True 1378767.2223421715 849797.5058056049 1015881.3922098137 1.0 0.616345886408597 0.7368041361500399 20.39494747612539 -10.722169559493247 10.073284644563289 1.000514172045849 0.6765750112793188 0.905766862514723 0.04917687452921315 0.0005686836267261585 1.5684774831270838e-05 0.04768422071213602 0.015871768005847865 1.8959655440358323e-11 10.722169559493247 -0.3239391607665302 LSFLVSYIASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSFLVSYIASK 11 0 P47897;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9;A0A0U1RQU2;A0A0U1RQL2 P47897 QARS Glutamine--tRNA ligase 0 7219500.0 1827500.0 3019800.0 2372200.0 False True 2395870.197535173 2569257.611088204 2126747.499749187 1.0 1.0723692851688746 0.8876722545057514 21.192118317832758 -6.80047257955632 1.4544251721570125 1.0399055500870376 0.8851058060813419 0.8334114236529385 0.031014774965616696 0.22009094924864112 0.9191699786962377 0.016777020451905347 0.03899825903545454 1.5831695215575656e-07 6.80047257955632 -0.15479974400569563 LSFLVSYIASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSFLVSYIASK 11 0 P47897;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9;A0A0U1RQU2;A0A0U1RQL2 P47897 QARS Glutamine--tRNA ligase 0 19271100.0 8184100.0 4521600.0 6565400.0 False True 7924300.225249854 6327098.459832499 4845724.782221876 1.0 0.7984425476046378 0.6115019174540538 22.917852109480148 -6.972029940914712 0.20396244180566958 1.1057380742248475 0.29902266452708426 0.9999941842911958 0.0003825318134977876 0.07564940036701606 0.006618111050501407 0.005875974509458303 0.01965154870512827 1.0665225910242904e-07 6.972029940914712 -0.8067154096977632 LSFLVSYIASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSFLVSYIASK 11 0 P47897;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9;A0A0U1RQU2;A0A0U1RQL2 P47897 QARS Glutamine--tRNA ligase 0 162012000.0 51686000.0 45397000.0 64929000.0 False True 78411440.75274372 37295550.661620095 52095754.69060829 1.0 0.4756391453031052 0.6643897139306855 26.224560832749166 -10.08427650293068 5.372568892932533 1.000005172092733 0.570014429616578 0.8737281945192709 0.0770570969674046 4.773885368372673e-06 8.136925740332987e-07 0.07461111021290848 0.024870071104993112 8.23613576738403e-11 10.08427650293068 -0.429990742476155 LSFLVSYIASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSFLVSYIASK 11 0 P47897;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9;A0A0U1RQU2;A0A0U1RQL2 P47897 QARS Glutamine--tRNA ligase 0 10660100.0 1827500.0 3340900.0 5491700.0 False True 2503176.136330533 3193287.9911210993 4194673.565111764 1.0 1.2756944846087492 1.675740473964744 21.25532837935565 -6.965803086881337 0.3439967808334111 0.9585698316767475 2.006240607705615 0.9999287491536115 0.0023417226142525053 0.07768956271660855 0.0139052869802832 0.005580899946812152 0.034526430309036606 1.0819243945905971e-07 6.965803086881337 1.0476707760288677 LSFLVSYIASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSFLVSYIASK 11 0 P47897;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9;A0A0U1RQU2;A0A0U1RQL2 P47897 QARS Glutamine--tRNA ligase 0 19672600.0 8184100.0 5522000.0 5966500.0 False True 6805441.767104119 5492251.889968815 7214067.5640209485 1.0 0.8070382611334725 1.0600439781722957 22.698257384914424 -6.702861995437275 1.8207722104776727 0.8805150581932937 1.059330304973003 0.4311189201080957 0.08140978666369456 0.38959977998721335 2.5130279735370435 0.03564440606589115 0.09134184502510531 1.9821567902506583e-07 6.702861995437275 0.17881524677970928 LSFLVSYIASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSFLVSYIASK 11 0 P47897;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9;A0A0U1RQU2;A0A0U1RQL2 P47897 QARS Glutamine--tRNA ligase 0 135458000.0 51686000.0 49363000.0 34409000.0 False True 66908545.88337667 46615905.65643565 28146915.066154744 1.0 0.6967107869552027 0.4206774290867948 25.995687154841615 -7.124551411501684 0.21144345473392545 1.1514755224236963 7.861225335891566e-12 0.999990265747676 0.0007381472378510792 0.07949861541742285 0.008280590712780802 0.010495249584784481 0.031762790804990594 7.506691851241696e-08 7.124551411501684 -1.151475522415835 down LSFQHDPETSVLVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSFQHDPETSVLVLR 15 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 156772600.0 1293100.0 62046600.0 93432900.0 False True 1695266.6223982123 52789489.13575257 83765359.77966274 1.0 31.139343179584234 49.41131894708332 20.69308075983145 -8.239888228626057 0.45842285694381363 6.624757045383266e-23 52.48972212184004 0.9937448714669593 1.5786869046288723 0.13247355488532464 0.144996125908162 3.363685449719318 4.286319010730113 5.755880534019725e-09 8.239888228626057 52.48972212184004 LSFQHDPETSVLVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSFQHDPETSVLVLR 15 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 124062000.0 38179000.0 22549000.0 63334000.0 False True 36967028.54312799 31552933.291481577 46744925.42072691 1.0 0.8535425901129705 1.2645031873793 25.13973574673095 -6.810362970207199 1.4130977863718093 0.9202154665066876 1.2717458920178168 0.8607401588837996 0.06346423416499529 0.20631406991374507 0.8119182530591922 0.03531396354370018 0.0816716380808743 1.5475227055569462e-07 6.810362970207199 0.35153042551112923 LSFQHDPETSVLVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSFQHDPETSVLVLR 15 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 161147000.0 20516000.0 109410000.0 31221000.0 False True 31124271.92050634 89884930.67576827 25050155.6653496 1.0 2.887936813601325 0.8048431053850681 24.8915367533132 -6.6680423931626835 1.9441575196258527 2.2070568035659686 0.8132969194771456 0.27051291635349084 0.8023123826150812 0.46560063110668726 3.390880615105342 0.3324412353151911 0.8905234166750607 2.1476208263302243e-07 6.6680423931626835 -1.393759884088823 LSFQHDPETSVLVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSFQHDPETSVLVLR 15 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 110988300.0 1293100.0 52008000.0 57687200.0 False True 1771194.0147135502 49710114.592542805 44062671.46517748 1.0 28.06587769583349 24.877382770686246 20.75629082135434 -9.37410923091511 9.292506260583991 0.9998981710633155 26.471630233260353 0.988384308123068 1.301697603673478 0.0 0.0 1.2603632846056816 0.4201210948685605 4.22562320780566e-10 9.37410923091511 25.471732062197038 LSFQHDPETSVLVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSFQHDPETSVLVLR 15 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 88023000.0 38179000.0 21002000.0 28842000.0 False True 31747530.116478026 20888858.05742938 34872728.84965936 1.0 0.657967973596389 1.0984391139000527 24.920141022165225 -6.6994516398707065 1.8329389742051792 0.7874938917108463 1.09710958969839 0.41489144569374914 0.14439107482094862 0.3966815297148871 2.59063911368272 0.06285632647761438 0.1617525548327424 1.9977832158367034e-07 6.6994516398707065 0.30961569798754374 LSFQHDPETSVLVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSFQHDPETSVLVLR 15 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 92285000.0 20516000.0 43475000.0 28294000.0 False True 26558366.43081988 41055578.032403536 23144782.320956215 1.0 1.545862323247421 0.8714685965812136 24.66266307540565 -6.691386712694575 1.8617975089750187 1.3417789849765844 0.8737785691851775 0.37682364662143963 0.23079696262295407 0.41367291111607324 2.7812470765096724 0.09913762376265546 0.2576815244613174 2.0352290235544724e-07 6.691386712694575 -0.46800041579140694 LSFSVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSFSVSR 7 0 H0Y6Y8;B1AL05;Q8N983-4;Q8N983-3;Q8N983-2;Q8N983;Q8N983-6;Q8N983-7;M0R051 H0Y6Y8 MRPL43 39S ribosomal protein L43, mitochondrial 0 15618900.0 4598400.0 4001600.0 7018900.0 False True 6028546.930968946 3404576.878114629 6292651.558042988 1.0 0.5647425353239183 1.043809002417701 22.523378878562934 -6.667475551699164 1.9457945235171392 0.7215899923061095 1.0418767299287628 0.26818000502268546 0.18499346957955018 0.46691239020768754 3.405493088729718 0.07659655857605348 0.20536225458372695 2.1504257326293024e-07 6.667475551699164 0.32028673762265325 LSFSVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSFSVSR 7 0 H0Y6Y8;B1AL05;Q8N983-4;Q8N983-3;Q8N983-2;Q8N983;Q8N983-6;Q8N983-7;M0R051 H0Y6Y8 MRPL43 39S ribosomal protein L43, mitochondrial 0 10750900.0 3917900.0 1774200.0 5058800.0 False True 3793528.409050034 2482647.3123307717 3733748.5192530574 1.0 0.654442789042529 0.9842416127280443 21.855108911169886 -10.631184643089915 9.220496660746987 1.0000718118222296 0.8193422011835897 0.28575844574184484 0.13463980596660463 0.00019883706195882557 7.953285044518953e-06 0.13041594972662182 0.04345481052043812 2.3378430783289252e-11 10.631184643089915 -0.1807296106386399 LSFSVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSFSVSR 7 0 H0Y6Y8;B1AL05;Q8N983-4;Q8N983-3;Q8N983-2;Q8N983;Q8N983-6;Q8N983-7;M0R051 H0Y6Y8 MRPL43 39S ribosomal protein L43, mitochondrial 0 12808700.0 4598400.0 3754200.0 4456100.0 False True 6298552.747087459 3588327.030520769 3403660.956260265 1.0 0.5697065936583706 0.5403877831830759 22.586588940085825 -13.999999999999998 0.3815762148032573 7.448255744339987 0.537882706724836 0.9998100473727611 0.0028955791322249095 24.235339029841207 0.2016053703545176 128.45649589773504 0.007909220650566423 1.0000000000000041e-14 13.999999999999998 -6.910373037615151 LSFSVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSFSVSR 7 0 H0Y6Y8;B1AL05;Q8N983-4;Q8N983-3;Q8N983-2;Q8N983;Q8N983-6;Q8N983-7;M0R051 H0Y6Y8 MRPL43 39S ribosomal protein L43, mitochondrial 0 9113700.0 3917900.0 2680100.0 2515700.0 False True 3257907.442398946 2665661.7693418018 3041721.2387174256 1.0 0.8182128610071726 0.9336426195330054 21.635514186604162 -10.411842819198638 5.294123547171028 1.000095475981729 0.8759277402842103 0.6063716618092436 0.04712400158683642 5.3145867194999655e-05 5.90428350867668e-06 0.04566266869920009 0.01520920611270452 3.873978274149092e-11 10.411842819198638 -0.12416773569751882 LSFSVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSFSVSR 7 0 H0Y6Y8;B1AL05;Q8N983-4;Q8N983-3;Q8N983-2;Q8N983;Q8N983-6;Q8N983-7;M0R051 H0Y6Y8 MRPL43 39S ribosomal protein L43, mitochondrial 0 14325600.0 3245400.0 6380200.0 4700000.0 False True 4201234.276398071 6025136.261353452 3844648.2260724586 1.0 1.4341347958626824 0.9151235025552225 22.002381807415624 -6.6847533636199525 1.8847305712855755 1.2734929079691004 0.9170048779792564 0.34616590878091535 0.18380708162696485 0.4280272772614813 2.9434841337812374 0.07813426190923241 0.2048476423033311 2.066553420904876e-07 6.6847533636199525 -0.35648802998984397 LSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSGDWNPLHIDPNFASLAGFDKPILHGLCTFGFSAR 36 1 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ET17;A0A2R8Y7L2;E7EPL9 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 2072940000.0 1254300000.0 108190000.0 710450000.0 False True 1623716075.9493775 102169131.39334658 581155389.8325915 1.0 0.06292302755801002 0.357916878720803 30.596652237968353 -10.351785417482477 5.746268314452718 1.0001487925704124 0.21041995706303593 0.9052333739363385 0.1204307354345714 0.00022960763269913942 2.5901191083869002e-05 0.11662807484379659 0.03886885272579912 4.448510116183085e-11 10.351785417482477 -0.7897288355073765 LSGGGDWHIAYVLLYGPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSGGGDWHIAYVLLYGPR 18 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 100020000.0 22946000.0 29328000.0 47746000.0 False True 34810759.577302516 24094189.25929013 38308982.172184825 1.0 0.6921477598265378 1.1004925671648726 25.053029958492946 -6.705027860883018 1.8129266419788646 0.8097848895581957 1.099399513241591 0.44145993738349054 0.12983284545659723 0.38516084160190556 2.464429590251358 0.05705911082225462 0.1458377835244656 1.9722962052037977e-07 6.705027860883018 0.2896146236833953 LSGGGDWHIAYVLLYGPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSGGGDWHIAYVLLYGPR 18 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 75384000.0 22946000.0 23997000.0 28441000.0 False True 29704049.333280995 22661545.85494167 23265029.829303566 1.0 0.7629109957594647 0.7832275515122099 24.824156280585395 -10.703276317024642 6.72099608511785 1.002299400341611 0.7730692736358374 0.9940245290777998 0.008294199154171972 0.0002883066785742914 1.2728363629385999e-05 0.008101962973992394 0.00267694126618631 1.9802666931721042e-11 10.703276317024642 -0.22923012670577358 LSGK(ub)PQNAPEGYQNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSGKPQNAPEGYQNR 15 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 3473000.0 1005400.0 1044100.0 1423500.0 True False 1318089.1363074484 888324.3498699242 1276209.8751761948 1.0 0.6739486165241558 0.9682272920869556 20.330016505800963 -10.332251860343199 7.910933823213768 1.0000009335298583 0.8210879548583726 0.3301329786327659 0.12013876621848277 1.9781039119919057e-06 1.6696316416617674e-07 0.11632446684462251 0.038774620066507524 4.653161645169583e-11 10.332251860343199 -0.1789129786714857 LSGPDDDPLHK(ub)QPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSGPDDDPLHKQPR 14 1 Q86TI2-4;Q86TI2;Q86TI2-2;M0R1L4 Q86TI2-4 DPP9 Dipeptidyl peptidase 9 1 14810900.0 3350400.0 4306200.0 7154300.0 True False 5082801.747049355 3537724.9655058333 5740249.469158912 1.0 0.6960186805553723 1.129347504551248 22.27719252937933 -6.7181296641456685 1.7658359160821264 0.8146964166357414 1.1286119874999114 0.5037787506481979 0.12794647243849722 0.35896044308355174 2.186412880606654 0.05755185214349306 0.14480690824688178 1.9136844848578875e-07 6.7181296641456685 0.31391557086417 LSGPDDDPLHK(ub)QPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSGPDDDPLHKQPR 14 1 Q86TI2-4;Q86TI2;Q86TI2-2;M0R1L4 Q86TI2-4 DPP9 Dipeptidyl peptidase 9 1 16311600.0 3350400.0 2206200.0 10755000.0 True False 4337158.846257508 2083423.030594336 8797700.355619006 1.0 0.4803658580298717 2.02844780822599 22.04831885147178 -6.816181191552322 1.388319679102071 0.7187941861883279 2.059553646382471 0.8753736943683491 0.22709360257249636 0.19849015122556357 0.7527471489368576 0.12857391821394829 0.29668547440263643 1.5269288769084769e-07 6.816181191552322 1.340759460194143 up LSGPLK(ub)EQYAQEHGLNFQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSGPLKEQYAQEHGLNFQR 19 1 Q15126 Q15126 PMVK Phosphomevalonate kinase 1 58438800.0 5402300.0 39279500.0 13757000.0 True False 7082467.6159476135 33419151.71029176 12333557.60646218 1.0 4.7185745876256115 1.741420967275681 22.755820669327676 -6.590711485399303 2.225135249728707 3.5157043379172235 1.7499915141677247 0.0 1.6110980446656227 0.6677737335886574 6.233699288333933 0.6040308639290691 1.7964378751778587 2.5661882647286933e-07 6.590711485399303 -1.7657128237494988 LSGPLK(ub)EQYAQEHGLNFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSGPLKEQYAQEHGLNFQR 19 1 Q15126 Q15126 PMVK Phosphomevalonate kinase 1 67851000.0 35207000.0 17140000.0 15504000.0 True False 34089373.05633746 23984091.383919194 11443037.28996984 1.0 0.7035650478019095 0.3356775518006335 25.022818731074842 -7.055326090750782 0.3110533471032032 1.0592157502745756 4.0222243923949345e-15 0.999956839747496 0.0017851666568078578 0.07311881186276394 0.012135864224875743 0.006222042658632657 0.03155399760764917 8.803875842583828e-08 7.055326090750782 -1.0592157502745716 down LSGSHLTPLCYSFISYVQNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSGSHLTPLCYSFISYVQNK 20 0 Q9NVI1;Q9NVI1-1;Q9NVI1-2;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 0 4260100.0 1006900.0 1996600.0 1256600.0 False True 1320055.6508334707 1698715.0626858445 1126579.0861583457 1.0 1.2868510972346445 0.8534330241660905 20.33216732124811 -6.728235982138051 1.7296206918499801 1.172962238080658 0.8537704163223463 0.5511044114262891 0.12060285166644677 0.33954622826030445 1.9891815518164513 0.055274792135286174 0.1374375970733702 1.869665945878525e-07 6.728235982138051 -0.3191918217583116 LSGSHLTPLCYSFISYVQNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSGSHLTPLCYSFISYVQNK 20 0 Q9NVI1;Q9NVI1-1;Q9NVI1-2;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 0 8093800.0 1006900.0 2310900.0 4776000.0 False True 1379178.1404493658 2208796.7968756156 3648007.1648075767 1.0 1.6015311815745152 2.6450587185343424 20.395377382771002 -6.962728594642996 0.395102042099727 0.939443370054608 3.3449499216159984 0.9998583968572367 0.008087336126711867 0.07874043304157965 0.017632489142524188 0.013442286229955884 0.08759566868418406 1.0896108153762754e-07 6.962728594642996 2.4055065515613903 LSHANSAVVLSAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSHANSAVVLSAVK 14 0 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 6747800.0 2056600.0 2257200.0 2434000.0 False True 2696222.5161427287 1920434.5584966864 2182153.028576645 1.0 0.7122685709353468 0.809337143174102 21.36250813471948 -10.761261797573024 9.963143950416432 1.0010003982209563 0.7608028570547244 0.890066729671299 0.0396280786742398 0.0008838093894355286 2.1177932356654854e-05 0.038509938331533385 0.01278990739562733 1.7327591562574248e-11 10.761261797573024 -0.24019754116623193 LSHANSAVVLSAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSHANSAVVLSAVK 14 0 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 6559050.0 2026100.0 611150.0 3921800.0 False True 1961782.56453107 855185.3821051468 2894562.9285219135 1.0 0.43592261322271664 1.475475917084526 20.903733717682403 -6.759353823132399 1.6150071274446616 0.6720890041268479 1.4791403534712884 0.6882932550737352 0.23722988761606337 0.2839994139819733 1.4598004780574598 0.11590888671917357 0.2787136988640339 1.7403883875277214e-07 6.759353823132399 0.8070513493444404 LSHANSAVVLSAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSHANSAVVLSAVK 14 0 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 8268300.0 2056600.0 2139800.0 4071900.0 False True 2816980.5975252385 2045256.560627657 3110201.083412891 1.0 0.7260456683388046 1.104090346289659 21.42571819624237 -6.712326805197514 1.786782343678494 0.8319790335055887 1.1032683995313974 0.4761489306922013 0.1154021887773765 0.3704469733733154 2.306823104645656 0.051368314766135 0.13013904096794895 1.9394259166039554e-07 6.712326805197514 0.2712893660258088 LSHETVTIELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSHETVTIELK 11 0 P62314;J3QLR7 P62314 SNRPD1 Small nuclear ribonucleoprotein Sm D1 0 21855170.0 7606070.0 13217800.0 1031300.0 False True 9971631.427286658 11245755.76258086 924590.9689281413 1.0 1.127774912719663 0.09272213635955938 23.249398128060857 -6.87598851221403 1.1018794030651524 1.0756832000116419 0.0247722026670801 0.970305312332225 0.07940124452696135 0.13124510316380775 0.29423670551736064 0.05569333907511291 0.1334157481512343 1.330489611097917e-07 6.87598851221403 -1.0509109973445618 down LSHETVTIELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSHETVTIELK 11 0 P62314;J3QLR7 P62314 SNRPD1 Small nuclear ribonucleoprotein Sm D1 0 14542200.0 5682400.0 3443900.0 5415900.0 False True 5502015.322388498 4819067.229701241 3997313.3164826985 1.0 0.8758731023688279 0.7265180269885929 22.391528726699693 -6.968662226123314 0.2883714198858629 1.0297573104043105 0.5680299377357357 0.9999699748308113 0.0006126206147773975 0.07673935932301304 0.01057705140813191 0.002632384495420455 0.01356989458507819 1.0748250358410803e-07 6.968662226123314 -0.4617273726685748 LSHETVTIELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSHETVTIELK 11 0 P62314;J3QLR7 P62314 SNRPD1 Small nuclear ribonucleoprotein Sm D1 0 35357700.0 9585100.0 8173000.0 17599600.0 False True 14541297.464673681 6714464.294059539 14121031.345821284 1.0 0.46175138844188535 0.9710984442843987 23.793652665404334 -10.694905714465683 9.882770258800504 1.000273836501475 0.7164249163631421 0.2924275037081392 0.20794006480050783 0.0012557772686719196 3.8767469929603785e-05 0.20152370421292015 0.06711236733180483 2.018804599528158e-11 10.694905714465683 -0.28384892013833285 LSHETVTIELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSHETVTIELK 11 0 P62314;J3QLR7 P62314 SNRPD1 Small nuclear ribonucleoprotein Sm D1 0 18576370.0 7606070.0 9194900.0 1775400.0 False True 10418239.625313045 8788638.914531827 1356087.0855107545 1.0 0.8435819515206964 0.13016470481403494 23.31260818958375 -7.043121701459893 0.7051209749859809 1.002693259942536 5.892140513857715e-17 0.9978887360869129 0.01739611545744321 0.07631182064203544 0.06021542213585138 0.016811259189368873 0.051918812338302284 9.054788248517256e-08 7.043121701459893 -1.002693259942536 down LSHETVTIELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSHETVTIELK 11 0 P62314;J3QLR7 P62314 SNRPD1 Small nuclear ribonucleoprotein Sm D1 0 11505100.0 5682400.0 2921400.0 2901300.0 False True 4725167.373002822 2905661.8383474997 3507948.4159044656 1.0 0.6149331037348981 0.7423966473541403 22.17193400213397 -10.919711516518328 11.157803305016317 1.0408427610540376 0.6786648755445193 0.894446809633536 0.052036773779021696 0.028380586828080968 0.00020421855322892872 0.02704650702564647 0.016794796519709474 1.203063313404401e-11 10.919711516518328 -0.36217788550951835 LSHETVTIELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSHETVTIELK 11 0 P62314;J3QLR7 P62314 SNRPD1 Small nuclear ribonucleoprotein Sm D1 0 32001200.0 9585100.0 13696000.0 8720100.0 False True 12408100.900567926 12933805.560248418 7133131.275781808 1.0 1.04236785821563 0.5748769560259879 23.564778987496783 -6.884761858902376 1.0528429467456637 1.0283625194700432 0.5385599116646969 0.9773294906662682 0.03178489312097227 0.12349743128516144 0.24748368348141583 0.023146141325090505 0.056717850453190874 1.3038815530597823e-07 6.884761858902376 -0.48980260780534635 LSHK(ub)GQQFGPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSHKGQQFGPR 11 1 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 1785720.0 324540.0 975350.0 485830.0 True False 425475.0828498306 829831.5818845222 435560.97201043274 1.0 1.9503646989767607 1.023705005456599 18.69871512009289 -6.640294750610307 2.0431947171696763 1.621347230561824 1.0275507169139588 0.1557571780031114 0.40660360752157626 0.5326715283397955 4.25029590207927 0.16202971840373717 0.4502980665053859 2.2893133950422051e-07 6.640294750610307 -0.5937965136478651 LSHK(ub)GQQFGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSHKGQQFGPR 11 1 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 4861740.0 845990.0 853150.0 3162600.0 True False 819134.5105215134 1193817.2441184756 2334220.1840337124 1.0 1.4574129508454174 2.8496176806756663 19.643740851490282 -6.951125876443243 0.546348567875313 0.9803161872244909 3.3917093357021644 0.9992866692623787 0.02100850318778429 0.08303687517507014 0.034116242266762964 0.022910629998339194 0.11541773297174632 1.1191134712396015e-07 6.951125876443243 2.4113931484776736 up LSHK(ub)GQQFGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSHKGQQFGPR 11 1 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 2000200.0 324540.0 659560.0 1016100.0 True False 444531.20836372726 630418.4583267485 776118.1072363858 1.0 1.418164678802311 1.7459249038851403 18.76192518161578 -6.973859301712384 0.13767686476987426 0.5460908585325455 2.6265320865766677 0.9999989999359494 0.0003052223497389971 0.07506918185121729 0.004160702264336314 0.01898407192946804 0.04314250186852473 1.0620395701963702e-07 6.973859301712384 2.0804412280441222 LSHNGIFTLYSYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSHNGIFTLYSYR 13 0 Q5JRX3;Q5JRX3-2;Q5JRX3-3;A0A0A0MRX9;B1APQ0 Q5JRX3 PITRM1 Presequence protease, mitochondrial 0 9534300.0 3369400.0 1783400.0 4381500.0 False True 3262440.241316317 2495520.9203081382 3233853.707817524 1.0 0.7649246379149783 0.9912376836403726 21.637520045153458 -10.662013560629827 8.592972646281089 1.0001519716541978 0.8780811607981518 0.27899641301975053 0.09239191402706225 0.00026932654403644644 1.059326724271379e-05 0.08956879253482078 0.029819362029253282 2.177641775507052e-11 10.662013560629827 -0.12207081085604599 LSHNGIFTLYSYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSHNGIFTLYSYR 13 0 Q5JRX3;Q5JRX3-2;Q5JRX3-3;A0A0A0MRX9;B1APQ0 Q5JRX3 PITRM1 Presequence protease, mitochondrial 0 12879400.0 2480500.0 3654700.0 6744200.0 False True 3397607.882992002 3493223.269523266 5151358.8611589745 1.0 1.028141972182812 1.5161722713636347 21.696087930408527 -6.91875035301911 0.8339267001933504 0.9887397952768351 1.5926572515662845 0.9938271684309858 0.018618225268065707 0.09891232641680152 0.1094596217598182 0.015936351577567676 0.04718241227061557 1.205728834428907e-07 6.91875035301911 0.6039174562894494 LSHNGIFTLYSYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSHNGIFTLYSYR 13 0 Q5JRX3;Q5JRX3-2;Q5JRX3-3;A0A0A0MRX9;B1APQ0 Q5JRX3 PITRM1 Presequence protease, mitochondrial 0 9906800.0 3369400.0 2282400.0 4255000.0 False True 2801805.3897289415 2270104.2581790695 5144700.827102849 1.0 0.8102290996016283 1.8362091978131891 21.417925320587734 -6.858944129721535 1.1911187292637189 0.8973179403931014 1.88488500561569 0.9523378022279009 0.09730533623619693 0.14789334894124573 0.39931990954467234 0.06374437401601404 0.1486202024040079 1.3837443807988555e-07 6.858944129721535 0.9875670652225886 LSHYLTLLTQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSHYLTLLTQR 11 0 Q8N3C0 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 0 9393300.0 2373500.0 2133700.0 4886100.0 False True 3111681.485006698 1815360.2770974587 4380533.2427807525 1.0 0.5834017028556993 1.4077704494781615 21.569262961422393 -6.769319023446351 1.5771035606683943 0.7608431622210796 1.4122839293510545 0.7279407859193219 0.17554396881776196 0.26752833215782706 1.3131172636025303 0.08774192253267628 0.20898926394401915 1.7009085982614483e-07 6.769319023446351 0.6514407671299749 LSHYLTLLTQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSHYLTLLTQR 11 0 Q8N3C0 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 0 8195050.0 3120900.0 968850.0 4105300.0 False True 3021828.7377942894 1355716.857486003 3029998.77363991 1.0 0.4486411954886549 1.0027036726944307 21.526990467372798 -10.92123489190622 10.395186457107842 1.0416381537424921 0.7256724340915801 0.2463402934662966 0.22619505912943105 0.12624465310794622 0.0009565636261204049 0.12666975524899193 0.07300414141689071 1.198850719045461e-11 10.92123489190622 -0.315965719650912 LSHYLTLLTQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSHYLTLLTQR 11 0 Q8N3C0 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 0 10220800.0 2373500.0 2420400.0 5426900.0 False True 3251047.091425733 2313458.724807543 4145177.990513872 1.0 0.7116041877427821 1.275028590464379 21.632473022945284 -6.767543893520764 1.5836842959672148 0.8340695113897374 1.2779217422867617 0.7211669635730718 0.12147107636883674 0.27040536365870804 1.338024528485401 0.06046990898603291 0.14428026401479108 1.7078750988484106e-07 6.767543893520764 0.4438522308970243 LSHYLTLLTQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSHYLTLLTQR 11 0 Q8N3C0 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 0 7809800.0 3120900.0 1852600.0 2836300.0 False True 2595166.6293123527 1842619.6760876926 3429357.21643051 1.0 0.7100197942110313 1.3214400870048157 21.307395742807074 -6.77767903366686 1.5444920496691796 0.835320984176675 1.325975781475009 0.7592969403505114 0.12251706257657584 0.25416123268300167 1.1973058270930543 0.062483990553949244 0.1477504700358074 1.668479850864212e-07 6.77767903366686 0.49065479729833406 LSILSLLGHVIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSILSLLGHVIR 12 0 A0A2R8Y6S8;A0A2R8Y5J1;A0A2R8Y5Q4;A0A2R8Y6N1;A0A2R8YGL0;A0A2R8Y5F8;Q86WV8;A0A2R8Y7E9;A0A2R8Y6W1;Q59IT9;A0A2R8YFV7;A0A2R8Y5N2;A0A2R8Y5S3;Q92574 A0A2R8Y6S8 TSC1 Hamartin 0 194018000.0 72511000.0 104990000.0 16517000.0 False True 93866918.9054972 99147214.20637274 13511075.478731683 1.0 1.0562529947977903 0.14393862754070247 26.484113469162835 -6.892220519612131 1.0091284978599155 1.0464421059724671 0.061962618891727286 0.9822827903051684 0.05556408389087573 0.1173609979968477 0.21145934754164858 0.041826058863733175 0.10514480689041407 1.2816796251284301e-07 6.892220519612131 -0.9844794870807398 down LSILTYVSQYYNYFHGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSILTYVSQYYNYFHGR 17 0 Q8IY33;Q8IY33-4;Q8IY33-2 Q8IY33 MICALL2 MICAL-like protein 2 0 59544000.0 14097000.0 26306000.0 19141000.0 False True 21386179.628747236 21611488.77028387 15357772.960201666 1.0 1.0105352683577844 0.7181167102682423 24.350175450458156 -6.8985429191974506 0.9704496120773076 1.012648522734064 0.6883164912402477 0.9858268626067449 0.0161233783320203 0.11248521609571818 0.18353760271172265 0.012494409185203729 0.032276503356600324 1.2631562660892237e-07 6.8985429191974506 -0.3243320314938163 LSILTYVSQYYNYFHGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSILTYVSQYYNYFHGR 17 0 Q8IY33;Q8IY33-4;Q8IY33-2 Q8IY33 MICALL2 MICAL-like protein 2 0 52389000.0 14097000.0 21103000.0 17189000.0 False True 18248844.393413346 19928599.498972133 14060778.374033943 1.0 1.092047204159682 0.7705023984482533 24.121301772550606 -6.830188225194808 1.3271543405527584 1.0491765763067975 0.7618216853921695 0.9062358596502879 0.04140220815544936 0.18057854886496189 0.6219903267852518 0.024494165565292728 0.05636517715994684 1.4784674747932406e-07 6.830188225194808 -0.28735489091462796 LSILYPATTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSILYPATTGR 11 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 76023000.0 19922000.0 22974000.0 33127000.0 False True 26117934.92492246 19546368.75195058 29699335.81662225 1.0 0.7483887530977379 1.1371241984481062 24.638537495577047 -6.731957930530265 1.7159030096841605 0.8489147439021681 1.1369852326460996 0.5684060169635639 0.10575609203570509 0.3325778140908988 1.9192137477188347 0.04882212976168042 0.12088988831100081 1.8537111810022759e-07 6.731957930530265 0.2880704887439315 LSILYPATTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSILYPATTGR 11 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 55982700.0 22711000.0 9231700.0 24040000.0 False True 21990051.73637287 12917965.952679511 17743202.81545892 1.0 0.5874459099753921 0.8068740823429076 24.390347662661842 -10.039186904433713 5.017643021747628 1.0000045729464828 0.6971599961570609 0.7174892633575916 0.08958117625589627 4.5826203127408505e-06 8.776229947766882e-07 0.08673790998221845 0.02891220031335884 9.137199252621101e-11 10.039186904433713 -0.3028445767894219 LSILYPATTGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSILYPATTGR 11 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 88395200.0 12495000.0 68154000.0 7746200.0 False True 18955828.506859396 55991386.21036747 6215160.174719924 1.0 2.9537820618131416 0.32787594446061236 24.17613817830995 -6.707479316902462 1.8041278252034911 2.2042275414528785 0.3344839332735042 0.453123846338195 0.8236465700705747 0.3801803086922435 2.410563134328741 0.3635186539188378 0.9263636823800813 1.9611945743435585e-07 6.707479316902462 -1.8697436081793744 LSILYPATTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSILYPATTGR 11 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 75738000.0 19922000.0 25637000.0 30179000.0 False True 27287701.771806814 24504272.569778115 23051341.756015047 1.0 0.8979969355680774 0.8447520406365369 24.70174755709994 -13.999999976826938 0.08213692014941448 1.5431824603552324 0.6918509405462178 0.999877697614376 0.000712325103868808 12.237504601939607 0.08125273845098428 1.1963201820176828 0.13850191017786656 1.0000000533579478e-14 13.999999976826938 -0.8513315198090147 LSILYPATTGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSILYPATTGR 11 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 42973000.0 22711000.0 12836000.0 7426000.0 False True 18885202.767891575 12766849.920253478 8978742.266055416 1.0 0.6760239790466822 0.4754379593594293 24.17075293809612 -9.060989557246726 0.11945834936787673 1.586329622728323 1.4712214349549303e-14 0.9999288619800606 0.0018227975160768112 0.5249017327658054 0.03936584844388773 0.3008446203256974 0.19696835015248268 8.689813239760674e-10 9.060989557246726 -1.5863296227283084 LSILYPATTGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSILYPATTGR 11 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 31640500.0 12495000.0 10804000.0 8341500.0 False True 16175023.813272322 10202747.902520718 6823432.591017753 1.0 0.6307717392136952 0.4218499255264666 23.9472645004024 -9.899963278566766 0.12471457362748332 1.728690439091978 2.4741953408510066e-14 0.9998604833358391 0.002823396289522759 1.444845330386303 0.056162392544021694 0.5703202352979045 0.22761645041622938 1.2590318637568087e-10 9.899963278566766 -1.7286904390919533 LSIMIEECGGLDKIEALQNHENESVYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSIMIEECGGLDKIEALQNHENESVYK 27 1 P52292 P52292 KPNA2 Importin subunit alpha-1 0 36713300.0 5670600.0 22311000.0 8731700.0 False True 8602714.776390301 18329427.73336134 7005875.667759931 1.0 2.13065621839114 0.8143796289733084 23.036360575230365 -6.679401565855763 1.9044043370344632 1.7157886377909362 0.8194629705777385 0.32118986909941394 0.47926606190162296 0.43986849651531507 3.083937603109036 0.2019927091455853 0.5330747029718497 2.0921770515586537e-07 6.679401565855763 -0.8963256672131976 LSIMIEECGGLDKIEALQNHENESVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSIMIEECGGLDKIEALQNHENESVYK 27 1 P52292 P52292 KPNA2 Importin subunit alpha-1 0 20581500.0 5670600.0 6811800.0 8099100.0 False True 7340703.4842370525 6432717.341946567 6625146.903783713 1.0 0.8763080208538275 0.902522069990992 22.807486897322814 -10.248675731327353 5.447739263305079 1.000008926420182 0.889415045422403 0.9595601332052488 0.0107018407464085 1.160348178737776e-06 1.6005118459974484e-07 0.010362848940539482 0.003454004248713333 5.6405865653469834e-11 10.248675731327353 -0.11059388099777889 LSINTQLLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSINTQLLAR 10 0 Q9UNQ2;A0A494C0G7;A0A0C4DGB1 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 0 13939900.0 2577100.0 6686100.0 4676700.0 False True 3378603.0566718983 5688559.942213676 4192799.9460741226 1.0 1.6837017686881532 1.2409862525265845 21.687995431275933 -10.293082482001017 4.790212437372095 0.9998100321318497 1.4623440106079377 0.5925327891843892 0.18073785263674474 0.0003668278275250821 5.413464359188909e-05 0.17506979210213042 0.058332891107338795 5.092341471934124e-11 10.293082482001017 0.462533978476088 LSINTQLLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSINTQLLAR 10 0 Q9UNQ2;A0A494C0G7;A0A0C4DGB1 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 0 13842000.0 4551900.0 3329500.0 5960600.0 False True 4407402.426084093 4658986.713113128 4399340.04583296 1.0 1.0570822136730917 0.9981707183797383 22.0714971999104 -6.6533379399078525 1.996410000005884 1.0369419023100066 0.9984171515017095 0.20779217394656457 0.024343314160685962 0.5003956037703654 3.82647434987466 0.009875678423679703 0.026972393481778118 2.22158052745994e-07 6.6533379399078525 -0.03852475080829709 LSINTQLLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSINTQLLAR 10 0 Q9UNQ2;A0A494C0G7;A0A0C4DGB1 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 0 17710500.0 2577100.0 7363600.0 7769800.0 False True 3529923.5135088456 7038251.803831114 5934733.264053996 1.0 1.993882240478035 1.6812639824466622 21.751205492798825 -10.028288040292956 5.956882049768024 0.9999986365187001 1.837573111462428 0.9054012144523498 0.12762586940938167 2.3110364985587855e-06 3.769716393863313e-07 0.12357341735869606 0.04119107223060676 9.369403870096679e-11 10.028288040292956 0.8375744749437279 LSINTQLLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSINTQLLAR 10 0 Q9UNQ2;A0A494C0G7;A0A0C4DGB1 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 0 38005400.0 7174400.0 11728000.0 19103000.0 False True 9287402.22856669 11075326.490259448 15626450.013332373 1.0 1.1925106954228133 1.682542612967456 23.146843687346397 -6.955074082428515 0.5000469411750621 0.9901901793182781 1.9060003075418879 0.9995416586416617 0.00615154024990508 0.08150997604326084 0.02800834266706921 0.007213532385011006 0.04042326324899803 1.1089856271436717e-07 6.955074082428515 0.9158101282236097 LSISGWFHGPSLTRPPNYFEPPIPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSISGWFHGPSLTRPPNYFEPPIPR 25 1 Q8N543;Q8N543-2 Q8N543 OGFOD1 Prolyl 3-hydroxylase OGFOD1 0 612932000.0 166696000.0 159696000.0 286540000.0 False True 252890019.10999814 131197001.0894571 229905243.40505633 1.0 0.5187907437042467 0.9091115743285059 27.913934857924257 -9.958103612127319 6.875634500993342 1.0000000196219176 0.7139511590163757 0.4172844884662612 0.15934781183479288 4.80218196153001e-08 7.021961293573793e-09 0.15428786686801116 0.051429285124228216 1.101276540332128e-10 9.958103612127319 -0.2860488606055419 LSISGWFHGPSLTRPPNYFEPPIPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSISGWFHGPSLTRPPNYFEPPIPR 25 1 Q8N543;Q8N543-2 Q8N543 OGFOD1 Prolyl 3-hydroxylase OGFOD1 0 31985600.0 18953000.0 6060000.0 6972600.0 False True 15760259.260263724 6027353.57718418 8430538.422340155 1.0 0.3824400016299809 0.5349238412337566 23.909787931900514 -10.318849900872397 8.653568191511344 1.0000006903569474 0.4586819214325156 0.9438308305957407 0.062251266841607325 8.291088106292152e-07 6.528455861836247e-08 0.06027460627168037 0.0200915099798216 4.798992808543247e-11 10.318849900872397 -0.5413187689244318 LSISGWFHGPSLTRPPNYFEPPIPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSISGWFHGPSLTRPPNYFEPPIPR 25 1 Q8N543;Q8N543-2 Q8N543 OGFOD1 Prolyl 3-hydroxylase OGFOD1 0 473842600.0 166696000.0 141030300.0 166116300.0 False True 215791258.06940672 133181839.82940291 135884837.89717457 1.0 0.6171790322783444 0.6297050173064416 27.685061180016707 -10.117054440327719 5.417807175882064 1.000006197305061 0.6234420247922445 0.9991707955479402 0.005113711974617772 3.827987503878859e-07 6.238684874278666e-08 0.004951411752802432 0.0016504434428409017 7.637400400996907e-11 10.117054440327719 -0.3765641725128164 LSIVPVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSIVPVR 7 0 P15880;H0YEN5;E9PMM9;E9PPT0;I3L404;E9PM36 P15880 RPS2 40S ribosomal protein S2 0 11739900.0 1008700.0 4056300.0 6674900.0 False True 1322415.4682646946 3451115.8513335637 5984245.378161986 1.0 2.6097062036503558 4.525238491058077 20.334744074337948 -6.968818836374717 0.28498834502397885 0.6025577904179688 6.5911587487436725 0.9999716480500616 0.007672701446402606 0.0766878444825334 0.010395422249224216 0.034396000480029984 0.17474170658723553 1.074437514747955e-07 6.968818836374717 5.988600958325704 LSIVPVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSIVPVR 7 0 P15880;H0YEN5;E9PMM9;E9PPT0;I3L404;E9PM36 P15880 RPS2 40S ribosomal protein S2 0 8917600.0 3361200.0 1368200.0 4188200.0 False True 3254500.5458278595 1914529.395068744 3091184.776693221 1.0 0.5882713393682157 0.9498184846384485 21.63400472551229 -10.21939451827128 7.815943391548232 1.0000001829613172 0.7690449120033321 0.35236577679757786 0.14760100397866247 4.706419947108653e-07 4.686437057245782e-08 0.1429141704397489 0.04763801919107121 6.034002443777242e-11 10.21939451827128 -0.23095527095798507 LSIVPVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSIVPVR 7 0 P15880;H0YEN5;E9PMM9;E9PPT0;I3L404;E9PM36 P15880 RPS2 40S ribosomal protein S2 0 12539100.0 1008700.0 4965300.0 6565100.0 False True 1381643.6490925355 4745916.627948638 5014558.59247869 1.0 3.4349787885362186 3.629415295161133 20.39795413586084 -10.232022869938552 0.5427542989146682 3.9916879831883324e-22 3.615493420077178 0.9995666384095021 0.02490431219999735 1.5427943920572154 0.2563220202360767 2.3955485972203845 0.03661242079070166 5.861072993029377e-11 10.232022869938552 3.615493420077178 LSIYGDLEFMNEQK(ub)LNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSIYGDLEFMNEQKLNR 17 1 Q9BXS4;Q5T6Z8 Q9BXS4 TMEM59 Transmembrane protein 59 1 7826700.0 2735600.0 2999700.0 2091400.0 True False 2274772.6076282067 2983540.0207061693 2528702.0704589644 1.0 1.311577258624087 1.1116285038685767 21.117290906176894 -10.240324273061743 3.8386430535005216 0.999743932651946 1.2116028813100586 0.5989236876906305 0.08162873752744124 10723725.07090184 9535921.083497483 20048.069440768322 0.02794368774253397 5.750104360849119e-11 10.240324273061743 0.2118589486581125 LSIYGDLEFMNEQK(ub)LNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSIYGDLEFMNEQKLNR 17 1 Q9BXS4;Q5T6Z8 Q9BXS4 TMEM59 Transmembrane protein 59 1 18132600.0 5693100.0 6044300.0 6395200.0 True False 7369830.177778356 5707929.391633279 5231339.220293318 1.0 0.7744994462482907 0.7098317185200476 22.813199945157443 -13.999999999999998 0.1751671078749421 2.153404829896982 0.6558157978796814 0.9995047692701318 0.0027678852258561713 12.146023275949466 0.13262239280615196 4.763460711349316 0.05034207635551801 1.0000000000000041e-14 13.999999999999998 -1.4975890320173004 LSK(ub)ALFPPEPLVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSKALFPPEPLVLR 14 1 Q96AD5 Q96AD5 PNPLA2 Patatin-like phospholipase domain-containing protein 2 1 15917900.0 3890000.0 6331400.0 5696500.0 True False 3766514.0792783415 8859561.037814831 4204415.758663134 1.0 2.352191137836477 1.1162617927791454 21.844798491477544 -6.624766021115451 2.0992716613955467 1.8942100710448777 1.1211057128437845 0.09901604861738988 0.5807876361885264 0.5727780187511176 4.802998560289587 0.22681113073192938 0.6437061967757348 2.3726516423827192e-07 6.624766021115451 -0.7731043582010932 LSK(ub)ALFPPEPLVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSKALFPPEPLVLR 14 1 Q96AD5 Q96AD5 PNPLA2 Patatin-like phospholipase domain-containing protein 2 1 9331400.0 3890000.0 0.0 5441400.0 True False 3234707.3562193736 0.0 6579171.581809039 1.0 0.0 2.033931004348589 21.62520376691182 -6.7730155579614 1.5628915272886 0.4286378039799654 2.0467029441841422 0.7419638110269535 0.421814052869421 0.26158326980318153 1.2613844427967749 0.2126834648738702 0.5048914689587896 1.6864926081880307e-07 6.7730155579614 1.6180651402041768 LSK(ub)EDIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSKEDIER 8 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 524109000.0 206279000.0 200719000.0 117111000.0 True False 270433766.6086773 170772507.59653422 104993477.12803595 1.0 0.6314762750897347 0.3882410042380671 28.01070005819483 -8.337181676688656 0.16756020149435819 1.3575400989562043 9.412785805320671e-10 0.999874310998086 0.0028194694228429558 0.09959537785146765 0.037497605702399225 0.13458979170131716 0.13029539899183637 4.600640765398957e-09 8.337181676688656 -1.3575400980149257 down LSK(ub)EDIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSKEDIER 8 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 597825000.0 211575000.0 278940000.0 107310000.0 True False 204858667.43529978 390322196.65288365 79202291.76900572 1.0 1.905324297670532 0.3866191885389475 27.610053692685444 -6.745192435540757 1.6673815677684183 1.5353728431120681 0.38461165485873594 0.6282155283013597 0.38036615463946116 0.3084633979905932 1.6856517052534798 0.1803188620209441 0.440041744656306 1.7980740134181807e-07 6.745192435540757 -1.1507611882533322 LSK(ub)EDIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSKEDIER 8 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 1099760000.0 310680000.0 462120000.0 326960000.0 True False 471324273.7503856 379651075.4399602 262336212.68834135 1.0 0.8054986695657103 0.5565938936284771 28.812144742844513 -6.967762062916897 0.3069707653042745 1.0397437355562473 0.3144713868981478 0.9999592885517832 0.0011578860875737285 0.07703575125583748 0.0116158526105489 0.003993277314943806 0.022163852010069346 1.0770551386226132e-07 6.967762062916897 -0.7252723486580995 LSK(ub)EDIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSKEDIER 8 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 503354000.0 206279000.0 154488000.0 142587000.0 True False 282545920.7803698 147662209.33650106 108910887.27144417 1.0 0.5226131346319548 0.38546260717776704 28.07391011971772 -13.999999999999998 0.17490823473258754 3.4399692799703625 0.2705918664582591 0.9995051721592861 0.005859017108435214 12.143054566515351 0.13252033835966873 10.059075551713278 0.10701091646852681 1.0000000000000041e-14 13.999999999999998 -3.1693774135121036 LSK(ub)EDIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSKEDIER 8 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 1059100000.0 310680000.0 469000000.0 279420000.0 True False 402181384.4183623 442899737.71586585 228568427.09131217 1.0 1.1012437543731437 0.5683217472182844 28.583271064936962 -6.857526652859998 1.1981640100962279 1.0546092695926137 0.5437069987882639 0.9505643737085604 0.05137971313539896 0.14937025965460693 0.4088830341327185 0.03347786481174212 0.07794278465723925 1.3882681086370682e-07 6.857526652859998 -0.5109022708043498 LSK(ub)EEIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSKEEIER 8 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 1 73953000.0 25419000.0 22745000.0 25789000.0 True False 24612087.758657154 31827197.113608062 19034087.246583603 1.0 1.2931530809454812 0.7733633746648931 24.552863706051042 -6.753716580240966 1.6363398745060138 1.1716081592289926 0.7720469343527813 0.6646865516976086 0.12321387966310682 0.29361716188175596 1.5479436265251179 0.059458184688555404 0.1437755280901324 1.763126283933874e-07 6.753716580240966 -0.3995612248762114 LSK(ub)EEIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSKEEIER 8 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 1 303579000.0 87929000.0 111940000.0 103710000.0 True False 133394721.47095938 91963432.40878811 83211673.0422921 1.0 0.6894083318642332 0.6238003432572679 26.991126338227545 -13.999999999999995 0.21852534955562058 2.862218464559391 0.5882067379754042 0.9994964578501636 0.003681890249454219 12.960026584572947 0.14810339555929086 10.406659622379413 0.03666573502575888 1.0000000000000123e-14 13.999999999999995 -2.2740117265839865 LSK(ub)EEIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSKEEIER 8 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 1 61227000.0 25560000.0 17671000.0 17996000.0 True False 35010222.73302789 16890236.78981742 13745715.439254016 1.0 0.4824372846358253 0.3926200511225712 25.061272904350208 -13.999999999999998 0.24637472547309117 4.534675757789798 0.35523978457159455 0.9995360082750799 0.005765839649029115 13.857188186518043 0.15707402661487924 24.188596838951433 0.042302542598516436 1.0000000000000041e-14 13.999999999999998 -4.179435973218204 LSK(ub)EEIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSKEEIER 8 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 1 85111000.0 25419000.0 38869000.0 20823000.0 True False 21137024.75263249 38659604.982107595 25176993.025326144 1.0 1.8289993712238413 1.1911323055147816 24.33326898148532 -10.431445814390434 5.420134098978353 0.9995773447113698 1.5100658383693153 0.46020979208680723 0.260408139118938 0.0013310675088569824 0.00013962462475740464 0.25234093624088855 0.08404636550204057 3.7030040377996153e-11 10.431445814390434 0.5104884936579455 LSK(ub)EEIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSKEEIER 8 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 1 345307000.0 87929000.0 187465000.0 69913000.0 True False 113825823.83971348 177032407.95502117 57189551.367958255 1.0 1.555292129528652 0.5024303751009179 26.762252660319994 -6.763396334595782 1.5995595157791678 1.321180448758349 0.4979085404432091 0.7047152923344434 0.2336865165199221 0.27725376094833026 1.3988083808525689 0.11522597728784012 0.275999615442828 1.7242636209015782e-07 6.763396334595782 -0.8232719083151399 LSK(ub)EETVLATVQALQTASHLSQQADLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSKEETVLATVQALQTASHLSQQADLR 27 1 P04844;P04844-2 P04844 RPN2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 1 83428900.0 8230500.0 5437400.0 69761000.0 True False 7969227.282647928 7608582.175666407 51488501.314859845 1.0 0.9547452853093067 6.460915153840587 22.92600841279502 -6.905045033862646 0.9288022561541905 0.80166975151331 7.101982570146154 0.9889139404450531 0.2721790245905008 0.10778702507452902 0.15720880667203319 0.21751547542383443 0.5817107415546497 1.2443855693894658e-07 6.905045033862646 6.300312818632844 up LSK(ub)EETVLATVQALQTASHLSQQADLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSKEETVLATVQALQTASHLSQQADLR 27 1 P04844;P04844-2 P04844 RPN2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 1 91020500.0 8230500.0 4739000.0 78051000.0 True False 6844025.422972647 4713470.066382153 94371103.2329505 1.0 0.688698503451043 13.78883002336382 22.706413688229297 -6.901460474599421 0.9520233121080287 0.47695557535162786 15.205261672458958 0.9872780443580695 0.6884136717471017 0.11033709572665072 0.17143350089457507 0.5408261467466154 1.4176782684718312 1.254698923561417e-07 6.901460474599421 14.72830609710733 up LSK(ub)FYQPYSEDTQQQIIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSKFYQPYSEDTQQQIIR 18 1 F5H459;Q92572 F5H459 AP3S1 AP-3 complex subunit sigma-1 1 20262300.0 2893000.0 3269300.0 14100000.0 True False 2801163.2985481387 4574748.539174279 10406787.009067008 1.0 1.633160245082963 3.7151661291795857 21.41759465953359 -6.949371721879853 0.5656981697414406 0.9735392644666275 4.475267847510452 0.9991510592392436 0.03379476793530244 0.08373899517098565 0.0370139136273161 0.035981707316516384 0.17329351217798897 1.1236428124873784e-07 6.949371721879853 3.5017285830438243 LSK(ub)FYQPYSEDTQQQIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSKFYQPYSEDTQQQIIR 18 1 F5H459;Q92572 F5H459 AP3S1 AP-3 complex subunit sigma-1 1 20720300.0 1292300.0 2355000.0 17073000.0 True False 1770098.2330943642 2250948.31305642 13040709.029472308 1.0 1.2716516354696692 7.367223347076866 20.755397995432205 -6.916229888849259 0.8522089927677863 0.846378244356452 8.269761228524615 0.9930681742370944 0.24474414189273905 0.1004414061355818 0.11748077670511162 0.20676537929533403 0.5987048697878725 1.212746726829717e-07 6.916229888849259 7.423382984168163 up LSK(ub)NEAPEGNLGDFAEFQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSKNEAPEGNLGDFAEFQR 19 1 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 15596600.0 4711200.0 5222500.0 5662900.0 True False 6176428.823325701 4443323.357145559 5076957.430372506 1.0 0.7194000747430372 0.8219891422044779 22.558341490292925 -10.355623352192133 5.005170253854838 1.0001365209923008 0.7706946084737138 0.8694754440153791 0.041881811411566876 6.384145761109274e-05 8.219102270569314e-06 0.040575931420354504 0.013517296508811468 4.409371064444205e-11 10.355623352192133 -0.22944191251858692 LSK(ub)NEAPEGNLGDFAEFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSKNEAPEGNLGDFAEFQR 19 1 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 22501200.0 7020800.0 5505900.0 9974500.0 True False 6797928.546991627 7704434.582889196 7361879.221414109 1.0 1.1333503330656127 1.0829591941904206 22.696663767119823 -10.385995687885568 5.1873576059599005 0.9999293761185136 1.1081547636277276 0.8599864828182626 0.020572096300343113 1.6814957172517098e-05 1.9903165613803517e-06 0.019931840431821928 0.0066396155306476246 4.111538034346497e-11 10.385995687885568 0.10822538750921396 LSK(ub)NEAPEGNLGDFAEFQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSKNEAPEGNLGDFAEFQR 19 1 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 62011000.0 12235000.0 10992000.0 38784000.0 True False 18561389.49831328 9030391.719112016 31118325.400368936 1.0 0.48651485493220376 1.676508399502997 24.145801378302636 -6.789453166653802 1.498621675621316 0.7128045703523942 1.688954480017359 0.7994997552567175 0.21821301506284263 0.23617763492657357 1.047897896918755 0.11461706481155734 0.26844182778233866 1.6238534537677324e-07 6.789453166653802 0.9761499096649648 LSK(ub)NEAPEGNLGDFAEFQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSKNEAPEGNLGDFAEFQR 19 1 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 16385600.0 4711200.0 6100800.0 5573600.0 True False 6453057.955392842 5831246.483352276 4257230.471895201 1.0 0.9036408046636375 0.6597229563601578 22.621551551815816 -6.955194149563657 0.4985729643499005 1.004945922241213 0.5479229732154991 0.9995483630153428 0.00304335528455844 0.08146467714055672 0.02783142804347624 0.00357872161113982 0.020120109642191353 1.1086790740365348e-07 6.955194149563657 -0.45702294902571383 LSK(ub)NEAPEGNLGDFAEFQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSKNEAPEGNLGDFAEFQR 19 1 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 53997800.0 12235000.0 7203800.0 34559000.0 True False 15838448.687906094 6802902.197350875 28269616.60528471 1.0 0.4295182142772245 1.7848728219747174 23.916927700395085 -6.792362314447196 1.486928873630471 0.6821385766327911 1.8002323044554869 0.8088853513955386 0.24290020436056536 0.23184074954905365 1.012576307778392 0.12856584408996571 0.3004882803444784 1.6130123239390488e-07 6.792362314447196 1.118093727822696 LSK(ub)VVTANHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSKVVTANHR 10 1 F8W9S7;Q14C86-3;Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6 F8W9S7 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 3664350.0 794450.0 1414600.0 1455300.0 True False 1041531.6434647428 1203547.1940676118 1304719.5162233324 1.0 1.1555550919834856 1.2526931125040741 19.990275240844994 -12.19260961118289 0.049114727873986734 1.5827429328895457e-08 1.8739474428159846 0.9999864061647833 0.000383684200658256 6.406434254654996 0.03971154976958351 1.1648374613208228 0.480797313193245 6.417862212341409e-13 12.19260961118289 1.8739474269885552 LSK(ub)VVTANHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSKVVTANHR 10 1 F8W9S7;Q14C86-3;Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6 F8W9S7 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 3700770.0 726070.0 1366200.0 1608500.0 True False 703021.305280625 1911730.784638879 1187185.5960343448 1.0 2.71930703988519 1.6886907795211923 19.42320888572175 -10.142359886359937 5.103968712475674 0.9999495039240756 2.2039989097048336 0.6453508396262813 0.4207473264235768 0.0002417724552119837 4.062652392325967e-05 0.40740378276458356 0.13579561568249712 7.205101673137085e-11 10.142359886359937 1.204049405780758 LSK(ub)VVTANHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSKVVTANHR 10 1 F8W9S7;Q14C86-3;Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6 F8W9S7 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 3776850.0 794450.0 1555400.0 1427000.0 True False 1088179.6342039898 1486677.2849800237 1089971.9899875238 1.0 1.366205760749729 1.0016471138837708 20.053485302367886 -10.124410624505892 12.920530057735196 0.9999996801356866 1.183926437323105 0.2533885088611819 0.1488304443569612 0.0 0.0 0.14410445810073833 0.048034819366912763 7.509125720326891e-11 10.124410624505892 0.18392675718741847 LSK(ub)VVTANHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSKVVTANHR 10 1 F8W9S7;Q14C86-3;Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6 F8W9S7 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 3717120.0 726070.0 2324000.0 667050.0 True False 603759.3753548085 2311480.1507221153 806527.0709092735 1.0 3.828479101237539 1.3358418996563082 19.203614161156025 -6.615699759922957 2.132729456632656 2.8823961422697204 1.3451356276161257 0.06852027451600307 1.2176790478106596 0.5970115630907483 5.153971759878199 0.4701452849003859 1.3507148377214528 2.4227033513740024e-07 6.615699759922957 -1.5372605146535947 LSKDPNIVIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSKDPNIVIAK 11 1 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 5450060.0 1560300.0 335860.0 3553900.0 False True 1510769.1305650403 469970.6494867625 2623026.975285338 1.0 0.3110803894377889 1.7362195998168852 20.526851780033986 -6.775237885301844 1.5542969254680898 0.6075164147570702 1.7458974708338626 0.750262643907017 0.29080584917197977 0.25802264439289974 1.2308077413304404 0.14741294373103914 0.34926109754694434 1.6778847030921478e-07 6.775237885301844 1.1383810560767924 LSKEDIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSKEDIER 8 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 1986610.0 315580.0 590330.0 1080700.0 False True 413728.43608106754 502255.0650883174 968879.5308064013 1.0 1.2139727929890312 2.3418248452628845 18.658324593680806 -6.938635856197213 0.6721441356422179 0.9869919198951052 2.6341322435155083 0.9979795860749059 0.026458172591942886 0.0883946910676973 0.0574873397735754 0.025496130880600994 0.09766995209794423 1.1517657075938512e-07 6.938635856197213 1.6471403236204032 up LSKEDIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSKEDIER 8 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 1468410.0 382080.0 550950.0 535380.0 False True 369951.07954001764 770947.2081662936 395147.91694427584 1.0 2.0839166333150274 1.0681085656935694 18.49697498309407 -6.630919395980671 2.0775698238930715 1.713655682624994 1.0722523157021597 0.12059091899484942 0.46484259216573615 0.556668221347361 4.580244304780085 0.18294213021941785 0.5147764797329164 2.339271361553687e-07 6.630919395980671 -0.6414033669228343 LSLATGLSWGPFHGSVQTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSLATGLSWGPFHGSVQTR 19 0 A0A087X1H8;A0A087WWQ0;A0A087WZP1;Q8IX07 A0A087X1H8 ZFPM1 Zinc finger protein ZFPM1 0 11703100.0 3349600.0 2315300.0 6038200.0 False True 5081588.088561521 1902116.625478531 4844747.12336292 1.0 0.37431538966334754 0.9533923330519998 22.276848005188825 -10.690688048939483 9.764363539951663 1.0003208439019722 0.6638538613576765 0.3100048465436519 0.23640717218545645 0.0016526932391768702 5.235313540433937e-05 0.2291068202434583 0.0763000867331885 2.0385057981539103e-11 10.690688048939483 -0.33646698254429563 LSLATGLSWGPFHGSVQTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSLATGLSWGPFHGSVQTR 19 0 A0A087X1H8;A0A087WWQ0;A0A087WZP1;Q8IX07 A0A087X1H8 ZFPM1 Zinc finger protein ZFPM1 0 9703400.0 3349600.0 3187900.0 3165900.0 False True 4336123.230487151 3010490.56261068 2589738.6848771926 1.0 0.6942815973134739 0.5972474828825939 22.047974327281274 -13.999999998033024 0.16059922836375964 2.5075427906411596 0.5024860486426097 0.9995348032334009 0.0037016246144271825 12.013701124517027 0.1266621324003274 5.64133726295747 0.08643175356916676 1.0000000045291294e-14 13.999999998033024 -2.00505674199855 LSLCFHPPGYSEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSLCFHPPGYSEQK 14 0 A0A140T8Y2;P36915-2;P36915 A0A140T8Y2 GNL1 Guanine nucleotide-binding protein-like 1 0 33113000.0 11216000.0 11717000.0 10180000.0 False True 14704284.615898507 9968869.272508271 9126671.253455333 1.0 0.6779567679021781 0.6206810798253614 23.809733261003583 -13.999999999999998 0.24289061240682008 3.161867154019914 0.5960421667639202 0.9995298515271629 0.0036201333317430083 13.727294922029625 0.15597195823511328 14.418582597485555 0.027519598110069446 1.0000000000000041e-14 13.999999999999998 -2.565824987255994 LSLCFHPPGYSEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSLCFHPPGYSEQK 14 0 A0A140T8Y2;P36915-2;P36915 A0A140T8Y2 GNL1 Guanine nucleotide-binding protein-like 1 0 34981000.0 11216000.0 10720000.0 13045000.0 False True 15362858.301003162 10246354.953700554 9964039.670208286 1.0 0.6669562885333317 0.6485798068942454 23.872943322526474 -13.999999999999998 0.41272915315090647 7.094426350936554 0.6478140436823294 0.9998549879637463 0.00194483817993062 28.746385119784108 0.21332603732494682 157.61307104294247 0.004544070961829972 1.0000000000000041e-14 13.999999999999998 -6.446612307254225 LSLDDLLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSLDDLLQR 9 0 F8VPD4;P27708;H7BZB3 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 3786060.0 839660.0 1622700.0 1323700.0 False True 1100802.3912790066 1380599.485235058 1186736.221826996 1.0 1.2541755869833815 1.0780647200885383 20.07012407845449 -10.299376097967214 3.4887399134283696 0.9994178002745718 1.1661201533758427 0.5426156676717153 0.07189696150760728 51437866.97126366 77241807.0055773 320802.9876434256 0.026311588626487623 5.0190775037114145e-11 10.299376097967214 0.1667023531012709 LSLDDLLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSLDDLLQR 9 0 F8VPD4;P27708;H7BZB3 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 4359160.0 839660.0 2029800.0 1489700.0 False True 1150104.9929583017 1940116.7243490126 1137863.5413345576 1.0 1.686904009831869 0.9893562312148071 20.133334139977382 -10.476319235375371 5.493260733488156 0.9995508732978725 1.338130120523339 0.2385585763832726 0.2847726881372842 0.0015684166652748049 0.00014951978682982398 0.2760872476940295 0.09190998988420111 3.339494746732996e-11 10.476319235375371 0.3385792472254664 LSLDGQNIYNACCTLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSLDGQNIYNACCTLR 16 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 65051000.0 7995000.0 33459000.0 23597000.0 False True 10481522.423690133 28467047.622160517 21155408.79840722 1.0 2.715926796838201 2.018352672756028 23.321344945360654 -10.463291032273384 5.82456827840081 0.9989773785983028 2.367139734797115 0.8366371436171288 0.28478344362837626 0.003783881132685574 0.00034866808480355795 0.2758943099118073 0.09191346120402462 3.441192500251637e-11 10.463291032273384 1.368162356198812 LSLDGQNIYNACCTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSLDGQNIYNACCTLR 16 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 44008000.0 7995000.0 16017000.0 19996000.0 False True 10950967.556751091 15309315.978863964 15273356.630546954 1.0 1.3979875202375176 1.3947038516364867 23.384555006883545 -10.306116616775833 5.261958450351873 0.9999115206193416 1.3963456859368857 0.9999485225137226 0.0013405520929505616 1.3919304378343894e-06 1.835514436311037e-07 0.0012982722678092453 0.0004326613275412973 4.9417797247568556e-11 10.306116616775833 0.39643416531754405 LSLEGDHSTPPSAYGSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSLEGDHSTPPSAYGSVK 18 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 38935000.0 3287000.0 19757000.0 15891000.0 False True 4309288.831353276 16809332.612182822 14246751.757235603 1.0 3.9007208080095364 3.3060563621495747 22.03901836807327 -10.636295232546795 9.074848109231882 0.998696912814749 3.6033885850795553 0.9623420494700706 0.24277074342196978 0.006398912459300524 0.0002564576911433197 0.23500490823907857 0.07835392051830688 2.3104935871247285e-11 10.636295232546795 2.6046916722648064 LSLEGDHSTPPSAYGSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSLEGDHSTPPSAYGSVK 18 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 25272700.0 6353100.0 3442600.0 15477000.0 False True 6151424.318011125 4817248.132921839 11423109.39995247 1.0 0.7831110136260848 1.856986091254681 22.552489064104396 -6.854134886440868 1.214834151020386 0.8836988576863474 1.9034964643011605 0.9461179272925351 0.10762291544372236 0.15297537843819234 0.4323525096186052 0.06923678123118601 0.1607143565164565 1.3991526957322125e-07 6.854134886440868 1.0197976066148131 LSLEGDHSTPPSAYGSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSLEGDHSTPPSAYGSVK 18 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8;H0YMD9;H0YNB8;H0YKN4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 33518000.0 3287000.0 17239000.0 12992000.0 False True 4502292.727834999 16477323.978250368 9923557.178639034 1.0 3.6597629195411643 2.204111944407253 22.10222842959616 -9.796972283157057 6.264160726240266 0.9999999440485684 2.9319374319754306 0.7013683545700397 0.5942670221148435 4.6646894634369935e-07 8.896882804982525e-08 0.5753965871086012 0.1917988566536128 1.5959810001154314e-10 9.796972283157057 1.931937487926862 LSLEHLNPSIYVGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSLEHLNPSIYVGLR 15 0 F8WE86;B5MBX2;P20062-2;P20062 F8WE86 TCN2 Transcobalamin-2 0 8136000.0 3595900.0 2323100.0 2217000.0 False True 3481750.122796142 3250725.944806457 1636301.1914256432 1.0 0.9336471114118456 0.46996514216004504 21.73138123712119 -6.932701107087728 0.7242752411694113 1.0063930091589728 0.36787632661132513 0.9970430296322287 0.0128213888252836 0.09125932118049813 0.07098525206627959 0.011874558504072838 0.04134972106714691 1.1676129225977424e-07 6.932701107087728 -0.6385166825476476 down LSLEHLNPSIYVGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSLEHLNPSIYVGLR 15 0 F8WE86;B5MBX2;P20062-2;P20062 F8WE86 TCN2 Transcobalamin-2 0 39296000.0 13860000.0 14162000.0 11274000.0 False True 21026633.301726386 11634680.451788958 9045688.958430255 1.0 0.5533306395196275 0.4302014891603004 24.32571453436046 -13.999999999990294 0.18080393449395923 3.323306222884319 0.3332011217042161 0.9994971905070634 0.005489255254464869 12.215225828220388 0.13480151168771684 9.971703229945359 0.09130826081687111 1.0000000000223489e-14 13.999999999990294 -2.990105101180103 LSLEHLNPSIYVGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSLEHLNPSIYVGLR 15 0 F8WE86;B5MBX2;P20062-2;P20062 F8WE86 TCN2 Transcobalamin-2 0 34349200.0 13860000.0 12071000.0 8418200.0 False True 17942043.221444923 11399238.238738202 6886173.978026216 1.0 0.6353366836790056 0.38380099150556235 24.09684085645291 -8.110017531733721 0.17770300461662172 1.306111523683752 1.9425461882856474e-16 0.9998829778706779 0.0027365567167890936 0.0912424516596813 0.0336255875620579 0.09835428157554611 0.11421495126228781 7.76215781477922e-09 8.110017531733721 -1.3061115236837517 down LSLELFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSLELFGR 8 0 O95071;E7EMW7;O95071-2;E5RFK7 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 0 7445500.0 1174000.0 2674200.0 3597300.0 False True 1608059.5261570709 2556045.0016031726 2747691.8287190706 1.0 1.5895213827759167 1.7087003211165228 20.616889381625903 -11.448236640635383 0.28049858209320194 2.3807543756071595e-12 1.749611301537879 0.999326617629804 0.008040168964609963 3.8092976531695837 0.1516878252944416 2.3667915483298403 0.046893793457208684 3.562569613848606e-12 11.448236640635383 1.7496113015354982 LSLELFGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSLELFGR 8 0 O95071;E7EMW7;O95071-2;E5RFK7 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 0 7088200.0 2353500.0 2524100.0 2210600.0 False True 3046652.144420678 2383631.616137775 1808293.482671444 1.0 0.7823773450811936 0.5935346068250571 21.538793357117587 -6.972784575102915 0.1796333524521961 1.1466967299711521 0.2241104892512283 0.9999967449356797 0.00029957783624920436 0.07540915660578952 0.005662702186191835 0.0072957360839506595 0.02121597882382867 1.0646710004467375e-07 6.972784575102915 -0.9225862407199238 LSLFLNVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSLFLNVR 8 0 H0Y4G9;Q99836-5;Q99836;Q99836-6;A0A3F2YP85;A0A494C0J8;A0A0A0MSI9;Q99836-3;Q99836-2;A0A3B3ITY3;Q99836-4 H0Y4G9 MYD88 Myeloid differentiation primary response protein MyD88 0 22433900.0 8180900.0 0.0 14253000.0 False True 10590336.319647817 0.0 11659100.248129958 1.0 0.0 1.100918790133162 23.336245070254115 -10.66599927395398 4.266516400933593 1.0168946515417416 0.5504593950707708 0.1818793434053546 0.4494482140122117 0.07292644411797208 0.005708982622378459 0.43938605539204767 0.14505878732088523 2.1577480164355444e-11 10.66599927395398 -0.46643525647097084 LSLIQFFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSLIQFFSK 9 0 P28749-2;P28749 P28749-2 RBL1 Retinoblastoma-like protein 1 0 3003490.0 725590.0 995200.0 1282700.0 False True 951255.5166235558 846720.0392592172 1149978.5085272256 1.0 0.890107888430037 1.2089060073039357 19.859473389709887 -6.8136409763635495 1.3992078080157986 0.9403617372084541 1.2149579198976708 0.8691071546173765 0.04783771169125487 0.20188205688080843 0.7782696752763434 0.026877918987990405 0.062077011881509325 1.5358861482883925e-07 6.8136409763635495 0.2745961826892167 LSLIQFFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSLIQFFSK 9 0 P28749-2;P28749 P28749-2 RBL1 Retinoblastoma-like protein 1 0 3341490.0 725590.0 1071800.0 1544100.0 False True 993860.2313324616 1024444.3320313685 1179415.381737725 1.0 1.0307730400459862 1.1867014541435983 19.92268345123278 -6.939508213524707 0.6641201396612421 0.9982340898735735 1.2281493473879936 0.9980988109624497 0.003563636430689815 0.08799161260377211 0.055636126403155406 0.003456150479594852 0.013449778404119872 1.1494545043403815e-07 6.939508213524707 0.2299152575144201 LSLK(ub)QGEVPESPEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSLKQGEVPESPEAR 15 1 H7BYP4;U5Y3L1;Q9H930-2;Q9H930;Q9H930-1;Q9H930-3 H7BYP4 SP140L Nuclear body protein SP140-like protein 1 7539600.0 2795100.0 1910700.0 2833800.0 True False 3664403.1677869023 1625631.0078502668 2540585.5597290494 1.0 0.44362777058509595 0.6933149665579574 21.80514681079625 -10.375260288917463 5.940636272120952 1.000083879962504 0.5684713685715309 0.7993011015832745 0.1019343709066376 0.00011326540120510746 1.1911366961739416e-05 0.09871658360473318 0.032899176743961214 4.214438406732269e-11 10.375260288917463 -0.4316125113909731 LSLK(ub)QGEVPESPEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSLKQGEVPESPEAR 15 1 H7BYP4;U5Y3L1;Q9H930-2;Q9H930;Q9H930-1;Q9H930-3 H7BYP4 SP140L Nuclear body protein SP140-like protein 1 11688800.0 2806100.0 2125900.0 6756800.0 True False 2717021.8914814796 2974782.9564220435 4986991.380344956 1.0 1.0948689687590325 1.8354623479407286 21.373594758956397 -6.930554065513422 0.7422271346707067 0.9889666473988612 1.9896716778335497 0.9966461294083611 0.021629978597785534 0.09235084224574111 0.0762772078082334 0.019771405204880407 0.06680773485621137 1.1733995963601064e-07 6.930554065513422 1.0007050304346885 LSLK(ub)QGEVPESPEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSLKQGEVPESPEAR 15 1 H7BYP4;U5Y3L1;Q9H930-2;Q9H930;Q9H930-1;Q9H930-3 H7BYP4 SP140L Nuclear body protein SP140-like protein 1 10078400.0 2795100.0 1935300.0 5348000.0 True False 3828524.004737332 1849792.0468187206 4084912.5455173613 1.0 0.48316062391925146 1.0669679856944294 21.86835687231914 -6.673039309847309 1.9263566299921564 0.6709757271750298 1.064655435612574 0.29269432423504727 0.2193883820471535 0.45417022958799214 3.251974305370725 0.0915868720505116 0.2437530439749155 2.1230522867784931e-07 6.673039309847309 0.3936797084375441 LSLK(ub)QGEVPESPEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSLKQGEVPESPEAR 15 1 H7BYP4;U5Y3L1;Q9H930-2;Q9H930;Q9H930-1;Q9H930-3 H7BYP4 SP140L Nuclear body protein SP140-like protein 1 10134800.0 2806100.0 2812000.0 4516700.0 True False 2333396.48130776 2796851.1978617036 5461121.0871387655 1.0 1.1986180746677904 2.340417126230542 21.154000034390673 -6.936747774330806 0.6891619688523886 0.986181052280367 2.6209334126107517 0.9977060493898054 0.028289596924098187 0.08928223556229896 0.06160554323613831 0.026901203042171227 0.09976162396035004 1.15678387374457e-07 6.936747774330806 1.6347523603303848 up LSLLCIDFNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSLLCIDFNK 10 0 P52888;K7EP46;K7EKB6 P52888 THOP1 Thimet oligopeptidase 0 28201000.0 7837000.0 11635000.0 8729000.0 False True 10274382.89361596 9899103.352874793 7825806.814480497 1.0 0.9634742500229042 0.7616814455438586 23.292548408672637 -6.9376060387969325 0.6814698384428914 1.002386165681032 0.7108940071808619 0.9978332357486526 0.0048783510386269276 0.08887596458888344 0.05971138226844698 0.004666624176309441 0.017558942217028695 1.1545000636667735e-07 6.9376060387969325 -0.2914921585001701 LSLLCIDFNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSLLCIDFNK 10 0 P52888;K7EP46;K7EKB6 P52888 THOP1 Thimet oligopeptidase 0 36506700.0 19991000.0 12751000.0 3764700.0 False True 19356396.64752015 17842540.795586552 2778612.131420889 1.0 0.9217904096769196 0.14355007194879277 24.20630707226833 -6.92886164501174 0.7788739199059634 1.013449157169517 9.359773196629911e-18 0.9957605226121814 0.025173374623236582 0.09394481135032719 0.0876354550065151 0.0224532206093756 0.07133118281730755 1.1779811880870898e-07 6.92886164501174 -1.013449157169517 down LSLLCIDFNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSLLCIDFNK 10 0 P52888;K7EP46;K7EKB6 P52888 THOP1 Thimet oligopeptidase 0 133280000.0 39366000.0 53846000.0 40068000.0 False True 59721100.040098086 44236760.599281736 32148542.237571705 1.0 0.7407224677639926 0.5383112872332635 25.83173740382629 -7.012797431828382 0.1380280953638682 1.2816132947083585 5.056151090169087e-09 0.9999990592699537 0.00018318330179704136 0.07219310591521094 0.004137727031209106 0.01172515552921541 0.02605849444057507 9.709627482356692e-08 7.012797431828382 -1.2816132896522074 LSLLCIDFNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSLLCIDFNK 10 0 P52888;K7EP46;K7EKB6 P52888 THOP1 Thimet oligopeptidase 0 64924000.0 7837000.0 19493000.0 37594000.0 False True 10734550.686961643 18631734.805269107 28715071.47273368 1.0 1.735679056217929 2.6750138231320166 23.35575847019553 -6.9677957318141885 0.3062963675617475 0.8488104055718559 3.591582024285144 0.9999597248439829 0.004350391982257035 0.07702463466519764 0.011576959941255759 0.015117659807262127 0.08369989752757769 1.0769716426199622e-07 6.9677957318141885 2.742771618713288 LSLLCIDFNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSLLCIDFNK 10 0 P52888;K7EP46;K7EKB6 P52888 THOP1 Thimet oligopeptidase 0 32600300.0 19991000.0 2844400.0 9764900.0 False True 16623402.251460552 2829076.6526308088 11806695.442203663 1.0 0.17018638001027994 0.7102454277171999 23.986712347702607 -10.035323408628576 6.397080376267036 1.0000003774912096 0.4402159039144582 0.5889018270783188 0.22047818297591376 1.1871139216656347e-06 1.792649608235555e-07 0.21347722426724217 0.07115902757231228 9.218846661977275e-11 10.035323408628576 -0.5597844735767514 LSLLCIDFNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSLLCIDFNK 10 0 P52888;K7EP46;K7EKB6 P52888 THOP1 Thimet oligopeptidase 0 110377000.0 39366000.0 39979000.0 31032000.0 False True 50960063.01987011 37754133.50563455 25384494.415208623 1.0 0.7408572766268682 0.4981252555616114 25.602863725918738 -6.971914375334749 0.20742859294668342 1.131328487847718 0.10089736205863714 0.9999937137920087 0.0005137644469612224 0.0756863169236862 0.006760036028288403 0.0074193353268923465 0.02530473826110895 1.0668064300026634e-07 6.971914375334749 -1.0304311257890808 down LSLLEEYGCCK(ub)ELASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSLLEEYGCCKELASR 16 1 P53350 P53350 PLK1 Serine/threonine-protein kinase PLK1 1 8504300.0 2062000.0 3195800.0 3246500.0 True False 2703301.9684364065 2718999.0971308313 2910583.322626989 1.0 1.005806650118153 1.0766770995659336 21.36629124436107 -6.9231510464897665 0.801013329393806 0.9986066734866799 1.0889769607160398 0.9950123130932675 0.002461788553846079 0.09635293579169123 0.09626665102869265 0.002157279318080705 0.006670240695182466 1.1935729107168982e-07 6.9231510464897665 0.09037028722935991 LSLLEEYGCCK(ub)ELASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSLLEEYGCCKELASR 16 1 P53350 P53350 PLK1 Serine/threonine-protein kinase PLK1 1 7309700.0 2062000.0 2608400.0 2639300.0 True False 2824377.123454755 2493152.263174677 2015951.6980897489 1.0 0.8827264045125366 0.713768597454101 21.42950130588396 -6.965918757680493 0.34191799430805364 1.0179234787319495 0.5729402313873925 0.9999308477723228 0.0009769772217441963 0.07765055249942567 0.01376829716021256 0.0023713508062673163 0.014603683280032524 1.0816362712086709e-07 6.965918757680493 -0.4449832473445571 LSLLEK(ub)LLPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSLLEKLLPER 11 1 P31689 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 4924260.0 759460.0 2558300.0 1606500.0 True False 995659.414621101 2176611.612175297 1440274.7906361483 1.0 2.186100568339032 1.4465536803910461 19.925292798188504 -10.057483936492664 4.755916967303743 0.99997553719023 1.8163271243761556 0.6189837572637316 0.3019187527804937 209276865.5029 3.339145311044162 61589.82093428202 0.10335481963607537 8.760241190570525e-11 10.057483936492664 0.8163515871859256 LSLLEK(ub)LLPER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSLLEKLLPER 11 1 P31689 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 10304400.0 3649800.0 3063900.0 3590700.0 True False 3533939.0967995096 4287331.24802742 2650187.9513089973 1.0 1.2131876443230771 0.7499246248213852 21.752845746309788 -6.781552452557637 1.5295953215980007 1.1204668343910833 0.7460592579005011 0.7729316413625349 0.09021707838539948 0.24816240676721726 1.146884072901214 0.04644796187576064 0.10946673531885386 1.6536650488706272e-07 6.781552452557637 -0.3744075764905822 LSLLEK(ub)LLPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSLLEKLLPER 11 1 P31689 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 5425660.0 759460.0 1972200.0 2694000.0 True False 1040252.885634794 1885061.6828067407 2057732.6846716108 1.0 1.812118676946922 1.9781081245604233 19.988502859711396 -10.964478031636792 0.3014025471580971 2.416307294127256e-11 2.0268428468065456 0.9992380555177756 0.011796762347846464 2.818113178412252 0.15379796697947726 2.026760529483548 0.05935738318641215 1.0852304435689726e-11 10.964478031636792 2.0268428467823827 LSLLEK(ub)LLPER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSLLEKLLPER 11 1 P31689 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 11268200.0 3649800.0 4316200.0 3302200.0 True False 3034970.413555134 4292947.773901382 3992674.7523522954 1.0 1.4144941099681647 1.3155564003259315 21.533251021744064 -10.051773029141483 4.962428040619681 0.9999928086007641 1.3650252551498796 0.9477788804831496 0.0403911508336575 3.2137440767426332e-06 6.139746544739663e-07 0.03910933377902075 0.01303618787467433 8.87619778436633e-11 10.051773029141483 0.3650324465491155 LSLLLNDISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSLLLNDISR 10 0 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 43374000.0 10714000.0 15344000.0 17316000.0 False True 14046157.754523594 13054735.010443531 15524306.426800825 1.0 0.9294168012771483 1.1052350897740124 23.7436722077126 -6.797735309751663 1.4650246427892408 0.9609434793540544 1.1075317480798565 0.8254911779193911 0.03017801689110298 0.22400642247810626 0.9493866737015637 0.016206573580490023 0.037745653895487 1.5931794291797452e-07 6.797735309751663 0.1465882687258021 LSLLLNDISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSLLLNDISR 10 0 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 30940400.0 9677600.0 9321800.0 11941000.0 False True 9370389.88525041 13044043.352544814 8813293.877678651 1.0 1.392049158282834 0.9405471902029751 23.159677646431167 -6.677156848687189 1.9124495517725721 1.2486903554472346 0.9423202043080431 0.3109877991433361 0.16626493137886192 0.44485237076244977 3.1433107910993305 0.06983140586193855 0.18481811926031358 2.1030187816982982e-07 6.677156848687189 -0.3063701511391915 LSLLLNDISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSLLLNDISR 10 0 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 32163700.0 5854600.0 17886000.0 8423100.0 False True 8881856.228592139 14694103.55604416 6758270.593024114 1.0 1.6543955652807634 0.7609074521233684 23.082429787783457 -6.710366152225927 1.7937160560957983 1.4021502782711108 0.7629657057808051 0.4669369471117917 0.2757421503234338 0.3743336325041692 2.347935414229782 0.12231919945597947 0.3106317043299145 1.9482013850856921e-07 6.710366152225927 -0.6391845724903057 LSLLLNDISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSLLLNDISR 10 0 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 52335000.0 10714000.0 15199000.0 26422000.0 False True 14675255.334963258 14527457.923628267 20181667.77817122 1.0 0.9899288013760913 1.3752174880452768 23.80688226923549 -6.9008977329421395 0.9555640979189395 0.9843729071573252 1.4164070102057968 0.9870077352800043 0.020437281128526934 0.1107484657909623 0.17371268022400838 0.016013147476159843 0.04185480718299732 1.2563257667022416e-07 6.9008977329421395 0.4320341030484717 LSLLLNDISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSLLLNDISR 10 0 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 27175300.0 9677600.0 8323900.0 9173800.0 False True 8047353.190372397 8279057.498535208 11091999.165141279 1.0 1.0287926107729453 1.3783412884638147 22.940082921865443 -6.923224516186511 0.8004285042255791 0.9931469672350336 1.4391172834364183 0.9950312942938656 0.012121824536312397 0.09631092075160373 0.09604712408114724 0.010626780476447927 0.03288451459257681 1.1933710107930587e-07 6.923224516186511 0.4459703162013847 LSLLLNDISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSLLLNDISR 10 0 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 22686300.0 5854600.0 9850300.0 6981400.0 False True 7578895.111419282 9302122.145890387 5710856.83521325 1.0 1.2273718014482984 0.7535210279673327 22.853556109875907 -6.776217134982606 1.550531010034362 1.1293755395181777 0.7501979142195927 0.7538080349524339 0.09601090523334585 0.2564942344587658 1.2176942280689853 0.048783546901905825 0.1154817433237705 1.6741056611745033e-07 6.776217134982606 -0.379177625298585 LSLLNGGLQEEELSTSLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSLLNGGLQEEELSTSLKR 19 1 O95235-2;O95235 O95235-2 KIF20A Kinesin-like protein KIF20A 1 21133900.0 3962500.0 12418000.0 4753400.0 True False 3836712.6064628414 17376572.1590145 3508341.941056677 1.0 4.529026263198375 0.9144135359909333 21.871439271518124 -6.651614512031688 2.002490762151769 3.287016803261327 0.9295037352663387 0.2007576090477594 1.5056221285025668 0.5045635204584186 3.87991671299155 0.6093480238304758 1.6681069421722965 2.230414028428679e-07 6.651614512031688 -2.3575130679949883 LSLLNGGLQEEELSTSLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSLLNGGLQEEELSTSLKR 19 1 O95235-2;O95235 O95235-2 KIF20A Kinesin-like protein KIF20A 1 28352900.0 6980700.0 6870200.0 14502000.0 True False 10590232.257529674 5644159.132882395 11635673.343547592 1.0 0.5329589564826954 1.0987174842435214 23.33623089406227 -6.6874729927813075 1.8757466211005298 0.7064997617827276 1.0966867385941659 0.35850023191709524 0.19762847496215405 0.42210343712329557 2.8774991462966675 0.08435608238042078 0.2203428888869388 2.0536527317959343e-07 6.6874729927813075 0.3901869768114383 LSLLNGGLQEEELSTSLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSLLNGGLQEEELSTSLKR 19 1 O95235-2;O95235 O95235-2 KIF20A Kinesin-like protein KIF20A 1 13071100.0 3962500.0 5078900.0 4029700.0 True False 3294994.318513956 5051538.957617282 4872291.63877235 1.0 1.533094891615937 1.4786950045394178 21.6518445469524 -10.13680438011505 5.082431168982795 0.9999792544447129 1.5058949480784967 0.9914022167995069 0.02220866090326618 5.2208816480369245e-06 8.866866569765962e-07 0.021504323680485448 0.0071678144845843455 7.29786154855123e-11 10.13680438011505 0.5059156936337837 LSLMLHGLVTPSLP ddPTM_RPMI8226_Bortezomib_8h_R1 2 LSLMLHGLVTPSLP 14 0 Q6P2E9;Q6P2E9-2;I3L0V0;I3L2F4 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 0 50502400.0 16991500.0 18574300.0 14936600.0 False True 25777347.74504209 15259571.0433317 11984374.463055665 1.0 0.5919759935840049 0.4649188342257085 24.61960049533085 -13.999999999999998 0.1633531727700415 3.0243557245411736 0.3445239538686683 0.9995279528069827 0.004959402097843755 12.033705787767206 0.12782879001253708 7.717153256575171 0.11020950505520336 1.0000000000000041e-14 13.999999999999998 -2.6798317706725054 LSLMLHGLVTPSLP ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSLMLHGLVTPSLP 14 0 Q6P2E9;Q6P2E9-2;I3L0V0;I3L2F4 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 0 22107600.0 10024000.0 6411000.0 5672600.0 False True 12976265.602580369 6054222.214278083 4640245.005791203 1.0 0.46656121257830785 0.3575947925163058 23.629371918750195 -13.999999999999979 0.22326807046356506 4.265894879388754 0.3011027852488789 0.9995013768409994 0.006267915629624827 13.090591571314285 0.14966288471829078 18.88230296720707 0.059031014077731585 1.000000000000049e-14 13.999999999999979 -3.964792094139875 LSLMPWFHGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LSLMPWFHGK 10 0 P41240;H3BUM9;K7ENL8;K7ES68;K7EQY5;P42679-3;P42679;P42679-2 P41240 CSK;MATK Tyrosine-protein kinase CSK;Non-specific protein-tyrosine kinase;Megakaryocyte-associated tyrosine-protein kinase 0 75628000.0 23592100.0 23075000.0 28960900.0 False True 30929471.566221412 19632299.945645496 25964303.880569197 1.0 0.6347441114088175 0.8394680725462262 24.882478849229262 -10.528153063003941 8.253372705337547 1.000033531264225 0.737106091977524 0.6873712392107552 0.08357820715133746 5.1574350440302094e-05 2.9484345756744027e-06 0.0809345401730348 0.02697475036691697 2.9637866467124185e-11 10.528153063003941 -0.26292743928670104 LSLMPWFHGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LSLMPWFHGK 10 0 P41240;H3BUM9;K7ENL8;K7ES68;K7EQY5;P42679-3;P42679;P42679-2 P41240 CSK;MATK Tyrosine-protein kinase CSK;Non-specific protein-tyrosine kinase;Megakaryocyte-associated tyrosine-protein kinase 0 66339180.0 26831000.0 8865080.0 30643100.0 False True 25979264.591546882 12404952.674781485 22616752.83670502 1.0 0.4774943736789917 0.8705694018784522 24.630857256462114 -9.776155628480437 6.140385918153648 1.0000000099608954 0.6740318877782625 0.47833362236995236 0.16047220828811576 2.1906814647448234e-08 4.147654995960124e-09 0.15537655218710184 0.051792182518841 1.6743427714292067e-10 9.776155628480437 -0.32596812218263294 LSLMPWFHGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LSLMPWFHGK 10 0 P41240;H3BUM9;K7ENL8;K7ES68;K7EQY5;P42679-3;P42679;P42679-2 P41240 CSK;MATK Tyrosine-protein kinase CSK;Non-specific protein-tyrosine kinase;Megakaryocyte-associated tyrosine-protein kinase 0 90917000.0 23592100.0 27709200.0 39615700.0 False True 32314736.922530036 26484915.92192904 30259287.570952177 1.0 0.8195924969286564 0.9363928180351427 24.945688910752153 -10.510946704367262 5.656099988897373 1.0002090507007737 0.8779926574818995 0.592645566348645 0.047683531417353604 0.00012591552119909884 1.0887182465629135e-05 0.04624815114426387 0.01538979358898068 3.083566335290922e-11 10.510946704367262 -0.12221639321887423 LSLMPWFHGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSLMPWFHGK 10 0 P41240;H3BUM9;K7ENL8;K7ES68;K7EQY5;P42679-3;P42679;P42679-2 P41240 CSK;MATK Tyrosine-protein kinase CSK;Non-specific protein-tyrosine kinase;Megakaryocyte-associated tyrosine-protein kinase 0 54487600.0 22261000.0 12362900.0 19863700.0 False True 18511007.829511445 12296298.603856489 24017107.830628175 1.0 0.6642695371914291 1.2974500390161658 24.14188010890983 -6.7626757182202475 1.6026503165016686 0.8056368177766531 1.3000538145754712 0.7017024956815388 0.14126712952795412 0.2784440264102621 1.4101630528083422 0.06953205859084531 0.16664117591947292 1.7271270328910177e-07 6.7626757182202475 0.4944169967988181 LSLMPWFHGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSLMPWFHGK 10 0 P41240;H3BUM9;K7ENL8;K7ES68;K7EQY5;P42679-3;P42679;P42679-2 P41240 CSK;MATK Tyrosine-protein kinase CSK;Non-specific protein-tyrosine kinase;Megakaryocyte-associated tyrosine-protein kinase 0 31365100.0 4338900.0 18039400.0 8986800.0 False True 5616791.58250558 17035491.53209297 7351294.612354887 1.0 3.0329577449789675 1.3088067278927886 22.421314840379534 -6.605860238275081 2.169111162616373 2.3619138513842155 1.31473088178049 0.037882450788712 0.8773815157163639 0.623951567889382 5.556911314065134 0.3347444693277624 0.9747249690645149 2.4782194532122276e-07 6.605860238275081 -1.0471829696037256 LSLNIDPDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSLNIDPDAK 10 0 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 0 68977000.0 34905000.0 34072000.0 0.0 False True 45760793.020500824 28988590.411615804 0.0 1.0 0.6334809451101279 0.0 25.447608718006826 -7.571722534399484 0.6879584990960913 0.9954483839781052 1.0760275600819491e-20 0.9870802631718396 0.04695150104395801 0.12090767638228064 0.14533929809344806 0.0421644836360584 0.07675971220144863 2.6808805606338774e-08 7.571722534399484 -0.9954483839781052 down LSLNIDPDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSLNIDPDAK 10 0 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 0 59088000.0 20496000.0 12573000.0 26019000.0 False True 19845365.69894318 17593464.46732881 19203843.34673149 1.0 0.8865276021729199 0.9676739465553991 24.242298811945638 -10.053560785567399 4.428258401027011 1.0000046941246288 0.9271007743570504 0.5183241851433649 0.03312785639552609 45907645.88180197 7.431319022652033 2197.769400079511 0.011340546389950563 8.839734361354334e-11 10.053560785567399 -0.07290391976757837 LSLNIDPDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSLNIDPDAK 10 0 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 0 115470000.0 11942000.0 93117000.0 10411000.0 False True 18116887.07714403 76499543.82355827 8353261.286696591 1.0 4.222554542500232 0.4610759702330391 24.110831750711778 -6.679914047699892 1.9024330444260855 3.0391125880271983 0.4754776060415915 0.3236714126384945 1.3658205911603503 0.43868617402418253 3.0696866846806534 0.5761266095053287 1.519528851213258 2.0897096695639528e-07 6.679914047699892 -2.563634981985607 LSLNIDPDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSLNIDPDAK 10 0 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 0 70876000.0 34905000.0 35971000.0 0.0 False True 47810321.7721572 34381682.27980995 0.0 1.0 0.7191267702329595 0.0 25.510818779529718 -7.391257815645786 0.7656663023795789 0.990195450694989 5.0863711706357734e-18 0.9875181389176106 0.04704780420778759 0.11245203246895756 0.13876876143092481 0.04067810673148773 0.07279596188316251 4.062021187497843e-08 7.391257815645786 -0.990195450694989 down LSLNIDPDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSLNIDPDAK 10 0 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 0 41062800.0 20496000.0 12592000.0 7974800.0 False True 17043332.12675382 12524164.396683684 9642293.808690913 1.0 0.7348424770191412 0.5657516814775261 24.022704087379914 -9.02914157030395 0.09339903760853156 1.6543387793821183 7.639658685918021e-07 0.9999724290436711 0.0009384131264225247 0.5009985310057532 0.030234442064024692 0.30083484639084856 0.21830695131110153 9.35100802477375e-10 9.02914157030395 -1.6543380154162497 LSLNIDPDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSLNIDPDAK 10 0 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 0 31248800.0 11942000.0 13276000.0 6030800.0 False True 15459154.412012633 12537178.929458067 4933256.281233577 1.0 0.8109873667938767 0.31911553179132224 23.881958072804228 -6.954596657990703 0.5058742716336375 1.0093685865623658 0.09930647069950423 0.9995143634284114 0.006324434345689361 0.08169086453795148 0.028717777155931597 0.007337486379885296 0.04058530783244156 1.1102054169108173e-07 6.954596657990703 -0.9100621158628616 down LSLNNGSITHLVIRPNGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSLNNGSITHLVIRPNGR 18 1 Q96HS1;F5GXG4 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 0 48632000.0 17266000.0 15201000.0 16165000.0 False True 22635893.204181846 12933070.053033926 14492400.86562922 1.0 0.5713523180364103 0.6402398498218677 24.432108900146485 -10.67003327308506 6.681106131585426 1.0024613774176325 0.6057960839291551 0.9776093849188323 0.028123217085687997 0.0010360336665839911 5.1167650949698326e-05 0.027360943942035736 0.009076729284553787 2.1377982977147233e-11 10.67003327308506 -0.39666529348847746 LSLNNGSITHLVIRPNGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSLNNGSITHLVIRPNGR 18 1 Q96HS1;F5GXG4 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 0 52838000.0 16214000.0 15114000.0 21510000.0 False True 15699295.4450949 21149099.018468782 15875885.713832004 1.0 1.3471368248615656 1.0112482925972501 23.90419647933636 -10.261792367693435 6.320336449211794 0.9999961309943767 1.1791925587294079 0.2750889034334316 0.13712591908332325 7.476057564109581e-06 8.733896889771218e-07 0.13277446664993892 0.04425720007859138 5.4727754885815547e-11 10.261792367693435 0.1791964277350312 LSLNNGSITHLVIRPNGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSLNNGSITHLVIRPNGR 18 1 Q96HS1;F5GXG4 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 0 44248000.0 11790000.0 15444000.0 17014000.0 False True 17886291.964455552 12687897.535477253 13651175.442498876 1.0 0.7093643311140854 0.7632199826340255 24.09235099520301 -10.6108690190762 6.49286406966636 1.0007844196822389 0.7362921568740569 0.9696680145801386 0.02198647766483309 0.0002503643671245903 1.500485394857763e-05 0.021348703095705142 0.007096105153138326 2.449801977787655e-11 10.6108690190762 -0.26449226280818194 LSLNNGSITHLVIRPNGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSLNNGSITHLVIRPNGR 18 1 Q96HS1;F5GXG4 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 0 60993000.0 17266000.0 17503000.0 26224000.0 False True 23649706.796105612 16729659.58531911 20030431.300233237 1.0 0.7073939533184392 0.8469631980186596 24.495318961669376 -10.089680934241052 4.730176598807336 1.0000107061524943 0.7771785756660228 0.7726440610361774 0.056978905562343675 6.6191436766085215e-06 1.2737978775387132e-06 0.05517231465310676 0.01838986269228263 8.134279027012801e-11 10.089680934241052 -0.22283213048647155 LSLNNGSITHLVIRPNGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSLNNGSITHLVIRPNGR 18 1 Q96HS1;F5GXG4 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 0 35162100.0 16214000.0 8595100.0 10353000.0 False True 13482659.401989983 8548796.490306217 12517764.433136513 1.0 0.634058625633193 0.9284343733617527 23.684601754770636 -9.91215372213761 6.378458313054533 1.0000000251867938 0.7812464994974571 0.4240569835432527 0.12017839576426269 4.303277199477378e-08 7.339733414421059e-09 0.11636224347971444 0.038787410447401076 1.2241828128987892e-10 9.91215372213761 -0.2187535256893367 LSLNNGSITHLVIRPNGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSLNNGSITHLVIRPNGR 18 1 Q96HS1;F5GXG4 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 0 61310000.0 11790000.0 31361000.0 18159000.0 False True 15262387.415644702 29615732.781465378 14854248.327074435 1.0 1.9404390659817603 0.9732585029160049 23.86347731729546 -6.65260724299721 1.9997746998017079 1.6090012607738107 0.9773648374496622 0.20454415743029353 0.4011359136893056 0.5021236016514541 3.8520833323225716 0.1625365044767218 0.44422837691941464 2.2253214646770486e-07 6.65260724299721 -0.6316364233241485 LSLSFALADGSHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSLSFALADGSHK 13 0 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 0 8389200.0 0.0 4341400.0 4047800.0 False True 0.0 3693680.04264466 3628972.4852393367 0.0 LSLSFALADGSHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSLSFALADGSHK 13 0 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 0 16981300.0 5661800.0 5928500.0 5391000.0 False True 5482069.258112631 8295780.966719071 3978935.373466686 1.0 1.5132572348374793 0.7258090305186249 22.386289123993603 -6.730814490555408 1.7203819354382082 1.308592257226585 0.7262150747393249 0.5630286045650662 0.2157466071587787 0.3346906162129509 1.9410479683025583 0.09936742939524264 0.24633502806603233 1.858598188155867e-07 6.730814490555408 -0.58237718248726 LSLSFALADGSHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSLSFALADGSHK 13 0 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 0 92799000.0 25168000.0 35300000.0 32331000.0 False True 38181696.02726181 29000439.199841168 25940763.678819302 1.0 0.7595377423552583 0.6794031270977996 25.18637785275157 -13.999999999999998 0.15353011673448605 2.169511042301391 0.594719639576217 0.9995548860839675 0.002874124040518503 11.972737915589812 0.12357270719383799 4.1735304034101475 0.07660331737330517 1.0000000000000041e-14 13.999999999999998 -1.574791402725174 LSLSFALADGSHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSLSFALADGSHK 13 0 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 0 25470700.0 0.0 7344700.0 18126000.0 False True 0.0 7020186.86832504 13845012.116688037 0.0 LSLSFALADGSHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSLSFALADGSHK 13 0 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 0 13709300.0 5661800.0 2846400.0 5201100.0 False True 4708037.560268089 2831065.8782338374 6288625.962830698 1.0 0.6013261028598567 1.3357212813893962 22.16669439942788 -6.759272206047756 1.6150770093799924 0.7682164235971051 1.338319849697044 0.6880208553884841 0.16766722914158716 0.2841517052102753 1.460651148225493 0.08191387860754357 0.197004104500777 1.7407154899441927e-07 6.759272206047756 0.570103426099939 LSLSFALADGSHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSLSFALADGSHK 13 0 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 0 78042000.0 25168000.0 33428000.0 19446000.0 False True 32580472.135449134 31567702.41442636 15907027.532809598 1.0 0.9689148236768236 0.48823809141494856 24.95750417484402 -6.920058356468351 0.8242957055010371 1.0105836086620261 0.41062099619306713 0.9941970452026887 0.017845558907661666 0.09813757328542937 0.1054371740589214 0.015380496801532965 0.046097503335928894 1.2021028963159986e-07 6.920058356468351 -0.599962612468959 down LSLSLSPSPQTGKPSMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSLSLSPSPQTGKPSMR 17 1 Q96R06;J3KSV2;J3QRV8;F5GZT2 Q96R06 SPAG5 Sperm-associated antigen 5 0 5618400.0 3228700.0 2389700.0 0.0 False True 4422437.642336737 2284115.1523188674 0.0 1.0 0.5164832920316728 0.0 22.076410369961604 -7.878626455300019 0.6032485220514642 1.0080924508282247 4.57914417453114e-18 0.9886154602127185 0.043567311546592734 0.11390455247475498 0.1593293333583948 0.04416540605287298 0.07743216210295377 1.3224325938395732e-08 7.878626455300019 -1.0080924508282247 down LSLSQPGLPGTK(ub)LYGPEGLELVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSLSQPGLPGTKLYGPEGLELVR 23 1 Q02556;H3BT31;H3BRT4;H3BPS5 Q02556 IRF8 Interferon regulatory factor 8 1 14893800.0 6912400.0 5304000.0 2677400.0 True False 6692969.645656457 7421914.859994591 1976108.6197216997 1.0 1.1089120753462849 0.2952513942752059 22.67421504064812 -6.873149825927854 1.1172504051513708 1.062946557009727 0.24464739433669047 0.9677293174965376 0.0647862217118401 0.13387304516954066 0.31040436187236453 0.04490965764591932 0.10695066489456202 1.3392145961665158e-07 6.873149825927854 -0.8182991626730365 down LSLSQPGLPGTK(ub)LYGPEGLELVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSLSQPGLPGTKLYGPEGLELVR 23 1 Q02556;H3BT31;H3BRT4;H3BPS5 Q02556 IRF8 Interferon regulatory factor 8 1 43206900.0 10114000.0 6594900.0 26498000.0 True False 15343677.432443045 5417988.568811121 21260658.685514003 1.0 0.35310886797940594 1.3856299299254002 23.87114096046317 -6.73729883346495 1.6964087593903245 0.6139125192509856 1.3859101613969242 0.5928630444576162 0.27181855953360917 0.32270907594788756 1.822389233608608 0.12681013071901234 0.31212942580432906 1.8310540597608986e-07 6.73729883346495 0.7719976421459387 LSLSQPGLPGTK(ub)LYGPEGLELVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSLSQPGLPGTKLYGPEGLELVR 23 1 Q02556;H3BT31;H3BRT4;H3BPS5 Q02556 IRF8 Interferon regulatory factor 8 1 47416100.0 10114000.0 7147100.0 30155000.0 True False 13092772.376745595 6749357.60219418 24667099.41642871 1.0 0.515502554232279 1.8840241552079964 23.64226728255562 -6.811026697756516 1.4103855699113785 0.7362757848939091 1.9084942153257198 0.8624514800861592 0.2101295256632217 0.20540319872778265 0.8051179809068807 0.1171477517127043 0.2708410720861073 1.545159449708978e-07 6.811026697756516 1.1722184304318106 LSLTGHISTVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSLTGHISTVR 11 0 O43660-2;O43660;H0YA24 O43660-2 PLRG1 Pleiotropic regulator 1 0 40600000.0 11444000.0 12725000.0 16431000.0 False True 15003194.823853655 10826479.601661509 14730877.737281367 1.0 0.7216116119780325 0.9818493934279031 23.838766409316143 -10.504859819938634 8.302939812892522 1.0000114797571493 0.8517305028145779 0.302072883868188 0.10624162939101808 2.2578538754481975e-05 1.3464259666112347e-06 0.10287597561647238 0.03428933844211279 3.127088555004496e-11 10.504859819938634 -0.14828097694257147 LSLTGHISTVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSLTGHISTVR 11 0 O43660-2;O43660;H0YA24 O43660-2 PLRG1 Pleiotropic regulator 1 0 26070600.0 11112000.0 3365600.0 11593000.0 False True 10759255.642401274 4709501.631372136 8556445.517454874 1.0 0.4377163056533769 0.7952637061373167 23.359074935585383 -10.26424266038929 5.314554770709588 1.000047157779868 0.6164900058953223 0.6053667327897432 0.14596811500751158 8.157059638131602e-05 1.129304880081366e-05 0.1413503499073592 0.047111006541760855 5.441984990372612e-11 10.26424266038929 -0.38355715188454564 LSLTGHISTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSLTGHISTVR 11 0 O43660-2;O43660;H0YA24 O43660-2 PLRG1 Pleiotropic regulator 1 0 56802000.0 12936000.0 18912000.0 24954000.0 False True 19624857.748277914 15537005.83986958 20021830.962273248 1.0 0.7917003037248999 1.0202280810942523 24.226178860809544 -11.84262021871015 12.661440990099859 0.9195003147017767 0.9153677732074242 0.0 0.1055966239835764 0.0 0.0 0.0 0.030800255887273132 1.4367452873685308e-12 11.84262021871015 -0.004132541494352493 LSLTGHISTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSLTGHISTVR 11 0 O43660-2;O43660;H0YA24 O43660-2 PLRG1 Pleiotropic regulator 1 0 35689400.0 11444000.0 8763400.0 15482000.0 False True 15675156.062471494 8376204.011311525 11825470.461798761 1.0 0.5343617618816137 0.7544084674289517 23.901976470839035 -10.092232581253704 4.987849443310634 1.0000094484963478 0.6443851146565468 0.7769013188702051 0.08983369136947204 24532363.776890278 49637886.460445434 1877.5057874987492 0.030752473301197774 8.08662713479498e-11 10.092232581253704 -0.35562433383980097 LSLTGHISTVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSLTGHISTVR 11 0 O43660-2;O43660;H0YA24 O43660-2 PLRG1 Pleiotropic regulator 1 0 20147000.0 11112000.0 4534600.0 4500400.0 False True 9240120.34506676 4510171.209752372 5441412.8325014515 1.0 0.4881074100036287 0.5888898227831617 23.13948021101966 -10.00134857136819 5.867154888165357 1.0000006381611997 0.5384986163932991 0.9654679300272389 0.04114424772640885 3.4342819274868284e-07 5.848121207927851e-08 0.03983780176347049 0.013279248853001323 9.968996158189843e-11 10.00134857136819 -0.46150202176790056 LSLTGHISTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSLTGHISTVR 11 0 O43660-2;O43660;H0YA24 O43660-2 PLRG1 Pleiotropic regulator 1 0 76228000.0 12936000.0 37656000.0 25636000.0 False True 16745907.006681893 35560410.49771569 20970511.047573123 1.0 2.1235284827227634 1.2522768124297803 23.997305182901993 -10.183460974980363 4.553263481465967 0.9998682947489722 1.6879026475856813 0.45390995658012645 0.3556870049930071 0.0004756465064315375 8.529760191224676e-05 0.34445772593573265 0.11479748722883938 6.554491808206624e-11 10.183460974980363 0.6880343528367091 LSLVLNFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSLVLNFR 8 0 Q14146 Q14146 URB2 Unhealthy ribosome biogenesis protein 2 homolog 0 20897400.0 6185200.0 7160600.0 7551600.0 False True 9383400.598689608 5882734.983976835 6059022.950016142 1.0 0.6269299623420489 0.6457171775083634 23.1616794278614 -10.163154533038695 4.841507699629156 1.0000322815415164 0.6363235699239203 0.9980024960556682 0.007669848479225477 2.6737995042039855e-06 4.6216276331168697e-07 0.007426957329801555 0.002475432951619437 6.86824007053083e-11 10.163154533038695 -0.3637087116175961 LSLVLNFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSLVLNFR 8 0 Q14146 Q14146 URB2 Unhealthy ribosome biogenesis protein 2 homolog 0 14533700.0 6185200.0 3780500.0 4568000.0 False True 8006863.3285195585 3570111.851673416 3736670.871638088 1.0 0.44588145259793227 0.4666834836968531 22.93280574995385 -10.762642222428614 10.813423093971185 1.0014747664978303 0.45628246816057166 0.9989033961587539 0.008492393634310536 0.0003023499021016323 6.636654832826534e-06 0.008233923629679531 0.0027409082595935465 1.7272602460001868e-11 10.762642222428614 -0.5451922983372586 LSMYGVDLHHAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSMYGVDLHHAK 12 0 A8K968;A0A0A0MRA8;Q9Y2J2-2;Q9Y2J2;Q9Y2J2-4;A0A1B0GTF8;Q9Y2J2-3;E9PII3;E9PK52;E9PHY5;O43491-2;O43491-3;O43491-4;O43491;A0A2R8Y5B3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0-4;Q9H4G0-3;Q9H4G0;Q4VXN0 A8K968;Q9H4G0-2 EPB41L3;EPB41L2;EPB41L1 Band 4.1-like protein 3;Band 4.1-like protein 3, N-terminally processed;Band 4.1-like protein 2;Band 4.1-like protein 1 0 5958800.0 1693200.0 1367600.0 2898000.0 False True 2219801.5969721233 1163559.4108630477 2598142.75957893 1.0 0.5241727064482601 1.1704391793946252 21.081999305424016 -6.709423221593603 1.79726294080746 0.707298030653694 1.1688944377413326 0.4623431653108694 0.20052940067430466 0.3762455689383986 2.3687236541399352 0.08880236095722606 0.22575748263092624 1.9524358723564595e-07 6.709423221593603 0.4615964070876386 LSMYGVDLHHAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSMYGVDLHHAK 12 0 A8K968;A0A0A0MRA8;Q9Y2J2-2;Q9Y2J2;Q9Y2J2-4;A0A1B0GTF8;Q9Y2J2-3;E9PII3;E9PK52;E9PHY5;O43491-2;O43491-3;O43491-4;O43491;A0A2R8Y5B3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0-4;Q9H4G0-3;Q9H4G0;Q4VXN0 A8K968;Q9H4G0-2 EPB41L3;EPB41L2;EPB41L1 Band 4.1-like protein 3;Band 4.1-like protein 3, N-terminally processed;Band 4.1-like protein 2;Band 4.1-like protein 1 0 3839700.0 1693200.0 1062300.0 1084200.0 False True 2319221.7970094983 1015364.0734436659 828134.2897999107 1.0 0.4378037817482221 0.35707420949033064 21.145209366946908 -13.99999999999913 0.27335594463472473 5.4184929036392795 0.3311367493338379 0.9995905876616976 0.005786005557495969 15.050256020557503 0.1655398664272042 37.02962057676348 0.0329757083124375 1.0000000000020042e-14 13.99999999999913 -5.087356154305442 LSNHISSLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSNHISSLFR 10 0 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 44033300.0 9122600.0 10925000.0 23985700.0 False True 11959816.943384062 9295032.585316455 21503889.851080872 1.0 0.7771885330116433 1.798011621154152 23.511691972067528 -6.849515291492575 1.2373393279592708 0.8811420936056833 1.8384598786048685 0.9396085980208012 0.10769782470656769 0.1579912706033162 0.4657005149232503 0.06811509555822277 0.15758279569493513 1.4141149332593048e-07 6.849515291492575 0.9573177849991852 LSNHISSLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSNHISSLFR 10 0 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 18871800.0 5979200.0 3387300.0 9505300.0 False True 5789393.568848604 4739866.554536139 7015576.777112382 1.0 0.8187155525304534 1.2117982123139093 22.464980805097372 -6.781317431573006 1.5308661861027961 0.8975274703333792 1.2150344383930294 0.7719799733428738 0.07670620372577845 0.2485341908203418 1.1505553700173514 0.03946252912413593 0.0930079724435413 1.6545601815104012e-07 6.781317431573006 0.3175069680596502 LSNHISSLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSNHISSLFR 10 0 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 15113100.0 5019800.0 7678900.0 2414400.0 False True 7615403.596537235 6308540.299480459 1937192.781730887 1.0 0.8283921159935614 0.25437821609503913 22.860489067138936 -6.948981852059017 0.5699109141013075 1.0071532984291656 0.04771312660008642 0.9991189489313926 0.009463774295695851 0.08389716186566937 0.037674235732362046 0.01002730793484311 0.04782559645781008 1.1246519690174646e-07 6.948981852059017 -0.9594401718290791 down LSNHISSLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSNHISSLFR 10 0 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 30552600.0 9122600.0 12297000.0 9133000.0 False True 12495471.748995306 11753677.879258925 6975973.500039279 1.0 0.9406349848459283 0.5582801226052294 23.57490203359042 -6.934354313133349 0.7101445001611201 1.0049821593086037 0.4703084407709751 0.9973268833006411 0.01012031121817185 0.0904392752575196 0.06706145694017518 0.009471739811234272 0.03380664949427286 1.163176680634405e-07 6.934354313133349 -0.5346737185376286 LSNHISSLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSNHISSLFR 10 0 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 14718400.0 5979200.0 6172300.0 2566900.0 False True 4971969.723472208 6139048.594794371 3103626.9219953697 1.0 1.2347316931180197 0.6242248232814924 22.24538608053165 -6.802476346416113 1.445737641067159 1.1291109420550178 0.6152699685122542 0.8392987582726281 0.10079845557880468 0.21725312752290166 0.8962092610994862 0.054841989185604165 0.12735724605165882 1.5758818498497613e-07 6.802476346416113 -0.5138409735427636 LSNHISSLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSNHISSLFR 10 0 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 15024900.0 5019800.0 4872500.0 5132600.0 False True 6498230.055051169 4601341.091728264 4198519.464923298 1.0 0.7080914422461195 0.6461020046004261 22.631615389231385 -13.999999999999998 0.21777492130286166 2.7445146211764953 0.6122284002448226 0.9994957625618044 0.003465004643643824 12.940046044999281 0.14785363375662913 9.696651444769971 0.034817009113784804 1.0000000000000041e-14 13.999999999999998 -2.1322862209316726 LSNHTGEKLYK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSNHTGEKLYK 11 1 Q8WTZ3 Q8WTZ3 Zinc finger protein ENSP00000375192 1 40594500.0 2909500.0 2237000.0 35448000.0 True False 3814382.6756380782 1903248.3197577056 31780181.001226403 1.0 0.49896627622432405 8.331670863597907 21.863018157744282 -6.891637820785674 1.0126148170136957 0.5955163683527853 9.027451801878636 0.9819270409464019 0.4812967122141577 0.11782546341155527 0.21415209042579553 0.3613455705981128 0.9063431890597418 1.2834004263057367e-07 6.891637820785674 8.431935433525851 up LSNIFVIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSNIFVIGK 9 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 319906000.0 88551000.0 90555000.0 140800000.0 False True 116091218.5291039 77044546.98062529 126231366.64896952 1.0 0.6636552527985596 1.0873463837174169 26.79068360586172 -6.69521899298218 1.848316118689498 0.7901659014631675 1.0859624016583629 0.39474047398355194 0.14210406881474286 0.4055538168536493 2.6901836119074387 0.061420814030333774 0.15887371321336144 2.0173488590505394e-07 6.69521899298218 0.29579650019519543 LSNIFVIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSNIFVIGK 9 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 183182000.0 69597000.0 26170000.0 87415000.0 False True 67387681.33047172 36619817.474747114 64518389.10621218 1.0 0.5434200547005342 0.9574211166253305 26.005981550756136 -10.386016688759524 8.588584149123244 1.0000013303362538 0.7504205856629323 0.3264026714236743 0.16901522578102196 4.305302053555123e-06 3.0806642050926756e-07 0.16364915912841888 0.05454942955878207 4.111339220389678e-11 10.386016688759524 -0.24958074467332148 LSNIFVIGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSNIFVIGK 9 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 150514000.0 38109000.0 77320000.0 35085000.0 False True 57814139.141088754 63521641.89608268 28150434.371698212 1.0 1.0987215729540731 0.4869126270824567 25.784919028463143 -6.865543376345729 1.1573149241122076 1.0545859906064292 0.4539764126092375 0.9600345606729266 0.05361407316889772 0.14120489390160743 0.3562706722458971 0.03603989594602019 0.08473112805029068 1.36287687836499e-07 6.865543376345729 -0.6006095779971917 down LSNIFVIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSNIFVIGK 9 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 227624000.0 88551000.0 64182000.0 74891000.0 False True 121290697.70079635 61346227.018508404 57203288.22856037 1.0 0.5057784989401181 0.4716213964707435 26.85389366738461 -13.999999999999998 0.3794827127855434 8.308623820038083 0.4685932748456768 0.9998066841623475 0.003356821596709292 23.970156665262383 0.20084798455082797 143.08913127629594 0.009272468952935861 1.0000000000000041e-14 13.999999999999998 -7.8400305451924055 LSNIFVIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSNIFVIGK 9 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 135930000.0 69597000.0 36586000.0 29747000.0 False True 57872989.16987146 36388903.95624756 35966960.16541211 1.0 0.6287718066443255 0.6214809478708666 25.786386826190412 LSNIFVIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSNIFVIGK 9 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 139500000.0 38109000.0 60693000.0 40698000.0 False True 49332851.74069583 57315381.196565114 33291381.596744023 1.0 1.161809609098359 0.6748318903543373 25.556045350555593 -6.817135533102804 1.3841998682449446 1.0874752211737857 0.664837933048905 0.8776728863231194 0.07082570721191864 0.19723009102814915 0.7432993243116784 0.0402161120472294 0.09277091523772252 1.5235772069521914e-07 6.817135533102804 -0.42263728812488066 LSNK(ub)VEAIDVEEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSNKVEAIDVEEAK 14 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 15411800.0 3418600.0 5138400.0 6854800.0 True False 4481817.705769493 4371770.749326321 6145531.051884636 1.0 0.9754459097473984 1.3712139706113942 22.095652538937582 -6.892123476832224 1.0097007068179538 0.9798048215091504 1.4067090029330425 0.9822241949747891 0.02413960702147527 0.1174385678670779 0.2119019882862367 0.01816322136346244 0.045643053735042294 1.2819660474894072e-07 6.892123476832224 0.4269041814238921 LSNK(ub)VEAIDVEEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSNKVEAIDVEEAK 14 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 16971200.0 4311100.0 5501900.0 7158200.0 True False 4174246.4902768303 7698837.36202947 5283252.678603075 1.0 1.8443657747482212 1.2656781747099697 21.99308436383255 -9.949788193805931 6.578968117367017 0.999999931636044 1.5550219747291048 0.5508664014634482 0.23624822342828558 2.3706457622435934e-07 3.73034604431825e-08 0.22874638599563743 0.07624878624239827 1.1225657981644447e-10 9.949788193805931 0.5550220430930608 LSNK(ub)VEAIDVEEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSNKVEAIDVEEAK 14 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 17630400.0 3418600.0 6799500.0 7412300.0 True False 4682548.804191281 6499075.607060355 5661667.401110381 1.0 1.3879354767734886 1.2090994964201345 22.158862600460473 -10.315882264089991 5.532974286768944 0.999951048733312 1.2985174865968168 0.7879146429732227 0.0730094832527045 4.409352000468263e-05 5.451761701711271e-06 0.07070269156056165 0.02356370939607512 4.831897755607617e-11 10.315882264089991 0.2985664378635048 LSNK(ub)VEAIDVEEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSNKVEAIDVEEAK 14 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 15160200.0 4311100.0 6462700.0 4386400.0 True False 3584870.6641124296 6427884.152354492 5303575.959577895 1.0 1.7930588728633974 1.4794329995419782 21.773489639266828 -10.181631029048685 4.595069924880572 0.999907519670816 1.6362459361145523 0.845854558369004 0.12803722707339155 89845308.26692471 21.672110375547497 104991.547683327 0.04383054834702575 6.582168123278559e-11 10.181631029048685 0.6363384164437362 LSNK(ub)VEAIDVEEAKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSNKVEAIDVEEAKR 15 2 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 12622400.0 4734200.0 4408500.0 3479700.0 True False 6206582.046058019 3750768.9841984073 3119654.0236393423 1.0 0.6043211797354117 0.5026363947965089 22.56536756680094 -13.999999999999998 0.1907722820023464 3.1267658382423353 0.4302508709291929 0.9994890011129385 0.004849882839504715 12.363430676011895 0.13851139104812768 9.776777448955988 0.06950312361486896 1.0000000000000041e-14 13.999999999999998 -2.6965149673131426 LSNK(ub)VEAIDVEEAKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSNKVEAIDVEEAKR 15 2 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 18770100.0 6125800.0 5730500.0 6913800.0 True False 5931339.832093391 8018718.534162725 5102868.3704459155 1.0 1.351923639710359 0.8603230492434832 22.49992660171448 -6.714546560248089 1.7791213411772497 1.2153429567275418 0.8613218997801615 0.48663044997021654 0.14819776998267786 0.3659984340789382 2.2609765340854446 0.06622161691822177 0.16730533023177777 1.9295384613404642e-07 6.714546560248089 -0.3540210569473803 LSNK(ub)VEAIDVEEAKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSNKVEAIDVEEAKR 15 2 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 74450000.0 18862000.0 16566000.0 39022000.0 True False 28615032.996909305 13609667.869251238 31309284.59604979 1.0 0.47561251705427743 1.0941551106871514 24.77026993471715 -6.682111202040553 1.8949303147246541 0.6688300082624042 1.091808323757524 0.33355219878994014 0.22214835972092284 0.4338612360673695 3.0139717261965324 0.0940182905609341 0.2472489413848232 2.079164244442427e-07 6.682111202040553 0.42297831549511977 LSNK(ub)VEAIDVEEAKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSNKVEAIDVEEAKR 15 2 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 13718700.0 4734200.0 4672700.0 4311800.0 True False 6484561.676944472 4466244.663447443 3293441.6443084837 1.0 0.6887504330981921 0.5078896320807846 22.628577628323832 -10.508136532767466 0.0963330724630329 1.8962954615254897 1.6780990498082756e-12 0.9999229088103019 0.001784472688065136 2.4094916362304017 0.0519818884371192 0.7982341537121528 0.29877012078614346 3.103583735317516e-11 10.508136532767466 -1.8962954615238117 LSNK(ub)VEAIDVEEAKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSNKVEAIDVEEAKR 15 2 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 19517100.0 6125800.0 8999000.0 4392300.0 True False 5093874.118953383 8950520.600838345 5310709.62229938 1.0 1.7571146031141758 1.042567895924085 22.280331877148758 -10.168046300759437 4.403545680207918 0.9999145571311775 1.399841249532628 0.29453081153943506 0.29171247171425924 0.00024853804224930364 4.695585676086436e-05 0.28251045424435633 0.09414979539590003 6.791312256006707e-11 10.168046300759437 0.3999266924014505 LSNK(ub)VEAIDVEEAKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSNKVEAIDVEEAKR 15 2 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 80794000.0 18862000.0 26016000.0 35916000.0 True False 24417230.825605635 24568186.73009804 29379656.529280543 1.0 1.0061823515357073 1.2032345821325061 24.5413962568096 -6.913587007640043 0.8709497594368727 0.9945690169709426 1.2307554263388398 0.9922062859744287 0.00833225399888838 0.10209364352986955 0.12625388895970296 0.006945098595120507 0.0196833376705586 1.2201493484913697e-07 6.913587007640043 0.23618640936789725 LSNKVEAIDVEEAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSNKVEAIDVEEAKR 15 2 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 10372400.0 2174800.0 4066200.0 4131400.0 True False 2851183.86079316 3459538.809923459 3703922.3591871685 1.0 1.2133692454898588 1.299082254960853 21.4431296449037 -13.9439962625075 0.12619444819618802 5.703068045191575e-08 1.4254645230158445 0.999663603046239 0.0023064364417640796 11.72790683468435 0.10963358920313593 2.9281994255615484 0.11194718263137005 1.1376370761659768e-14 13.9439962625075 1.425464465985164 LSNKVEAIDVEEAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSNKVEAIDVEEAKR 15 2 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 14537900.0 4388200.0 3934600.0 6215100.0 True False 4248898.992979233 5505706.298667946 4587178.860996624 1.0 1.295795995095536 1.079615888392818 22.01865761689158 -10.274336813710446 3.5710086298399286 0.9995209121426091 1.1877059417771079 0.5013028629858354 0.08825515958095978 48107611.814465575 65267404.177224904 242139.46139218207 0.034885904460698836 5.3169574682253104e-11 10.274336813710446 0.1881850296344988 LSNKVEAIDVEEAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSNKVEAIDVEEAKR 15 2 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 81138000.0 18897000.0 19511000.0 42730000.0 True False 28668130.555751994 16029109.609861193 34284396.77077568 1.0 0.5591264340968721 1.195906259185667 24.772944493942376 -6.720485291179273 1.757696881156991 0.7319111813867243 1.194930589514664 0.5147128156715199 0.18551082224546775 0.35439408602925415 2.1400803398018233 0.08379543484224262 0.2102277548758863 1.9033326991491841e-07 6.720485291179273 0.46301940812793974 LSNKVEAIDVEEAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSNKVEAIDVEEAKR 15 2 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 9531400.0 2174800.0 3521400.0 3835200.0 True False 2978882.331760136 3365812.9042874193 2929404.7484233663 1.0 1.1298911905320737 0.983390554635458 21.50633970642659 -6.67276142582641 1.9278026853182102 1.0827119677736816 0.983977703047667 0.2912740352917398 0.05514015641338922 0.4547878013729284 3.2611628711976706 0.023006441931726063 0.06124207023798733 2.1244111598819886e-07 6.67276142582641 -0.09873426472601465 LSNKVEAIDVEEAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSNKVEAIDVEEAKR 15 2 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 12076800.0 4388200.0 4127200.0 3561400.0 True False 3648982.730221556 4104965.9544149437 4306072.27394691 1.0 1.1249617380802737 1.1800747200810835 21.799062892325857 -13.999999999999808 0.11108100105339436 0.398146683270644 1.2796220364784399 0.9997375701732905 0.001220407869319964 12.006584576496442 0.10131342823937511 1.6174532466421097 0.08839792096817135 1.0000000000004418e-14 13.999999999999808 0.8814753532077959 LSNKVEAIDVEEAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSNKVEAIDVEEAKR 15 2 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 84958000.0 18897000.0 15555000.0 50506000.0 True False 24462539.01555873 14689350.576056082 41314426.23532245 1.0 0.6004834807504372 1.6888854508947555 24.544070816034825 -6.807344919316601 1.425591829901484 0.7815731642652481 1.7068048892158922 0.85279985084595 0.1724744628646085 0.2104435982100006 0.8434062067399438 0.0951428632098963 0.22036897866385793 1.5583143884763393e-07 6.807344919316601 0.9252317249506441 LSNLALVKPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSNLALVKPEK 11 1 O14737;O14737-2;K7EQA1 O14737 PDCD5 Programmed cell death protein 5 0 5533210.0 2406100.0 801210.0 2325900.0 False True 2329719.6725325543 1121137.3312549521 1716677.0144956699 1.0 0.48123271845672494 0.7368599041057726 21.151724939921404 -10.132334792349848 5.246998201355316 1.0000109518478042 0.6090463112809548 0.7572056578553465 0.1043593615383467 1.337033954262955e-05 2.2110320326333043e-06 0.10104834625709529 0.033681839104755584 7.373356079060625e-11 10.132334792349848 -0.39096464056684943 LSNLPGWSLK(ub)DGNAFLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSNLPGWSLKDGNAFLDK 18 1 E5RJ88;E5RK47;H0YBH8;E5RG70;G3XAN1;Q9NV88-3;Q9NV88-2;Q9NV88 E5RJ88 INTS9 Integrator complex subunit 9 1 25971300.0 6799000.0 12077000.0 7095300.0 True False 8913554.841609655 10275158.675777294 6361146.418923529 1.0 1.152756544202936 0.713648654432332 23.087569481380992 -6.812736523064661 1.402938199403613 1.0829864906307016 0.7054718879298019 0.866863348180379 0.06641146612381373 0.2030948302345703 0.7873045941120299 0.03721554745260558 0.08598795507347587 1.5390880881043442e-07 6.812736523064661 -0.37751460270089976 LSNLPGWSLK(ub)DGNAFLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSNLPGWSLKDGNAFLDK 18 1 E5RJ88;E5RK47;H0YBH8;E5RG70;G3XAN1;Q9NV88-3;Q9NV88-2;Q9NV88 E5RJ88 INTS9 Integrator complex subunit 9 1 33454000.0 10169000.0 11622000.0 11663000.0 True False 9846190.66122917 16262725.207929334 8608110.41749989 1.0 1.6516768532592219 0.8742579453996961 23.231134245454605 -6.684369971471395 1.8862555473609235 1.410707799942105 0.87710630507101 0.34415033441235954 0.27593884717685624 0.4289634760055972 2.9544243493232547 0.117220700946341 0.30745359553041596 2.0683785653880168e-07 6.684369971471395 -0.533601494871095 LSNLPGWSLK(ub)DGNAFLDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSNLPGWSLKDGNAFLDK 18 1 E5RJ88;E5RK47;H0YBH8;E5RG70;G3XAN1;Q9NV88-3;Q9NV88-2;Q9NV88 E5RJ88 INTS9 Integrator complex subunit 9 1 48837000.0 14689000.0 19783000.0 14365000.0 True False 22284286.909744494 16252569.084715523 11525751.453596847 1.0 0.7293286588232081 0.5172142819861494 24.409523460107792 -7.113482088229087 0.1460866838040791 1.2705133449251753 6.968502604487162e-10 0.999998273349871 0.0002595588132301321 0.07828969932966506 0.0051997615082434645 0.013790855894757705 0.030031018007869583 7.700482030900617e-08 7.113482088229087 -1.270513344228325 LSNLPGWSLK(ub)DGNAFLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSNLPGWSLKDGNAFLDK 18 1 E5RJ88;E5RK47;H0YBH8;E5RG70;G3XAN1;Q9NV88-3;Q9NV88-2;Q9NV88 E5RJ88 INTS9 Integrator complex subunit 9 1 27574400.0 6799000.0 12293000.0 8482400.0 True False 9312774.036066372 11749854.612485167 6479031.82051168 1.0 1.2616922269326525 0.6957144880161145 23.150779542903884 -6.780967644537259 1.5319704616012761 1.1479898839836329 0.6910839236983988 0.7708414609494503 0.11071368260030498 0.24907406329768375 1.154658105619896 0.0569153112277619 0.13419533648880982 1.6558933249242033e-07 6.780967644537259 -0.4569059602852341 LSNLPGWSLK(ub)DGNAFLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSNLPGWSLKDGNAFLDK 18 1 E5RJ88;E5RK47;H0YBH8;E5RG70;G3XAN1;Q9NV88-3;Q9NV88-2;Q9NV88 E5RJ88 INTS9 Integrator complex subunit 9 1 35835600.0 10169000.0 15772000.0 9894600.0 True False 8455974.063083502 15687033.10550313 11963515.112538634 1.0 1.8551420556016698 1.4148003557352558 23.01153952088888 -10.245978072971583 5.297313507333295 0.999935668554665 1.63497120566851 0.7349218237438833 0.17976874619074318 0.00013660881151342626 1.944500889466931e-05 0.17407786971905395 0.058020113347064 5.675732608056802e-11 10.245978072971583 0.635035537113845 LSNLPGWSLK(ub)DGNAFLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSNLPGWSLKDGNAFLDK 18 1 E5RJ88;E5RK47;H0YBH8;E5RG70;G3XAN1;Q9NV88-3;Q9NV88-2;Q9NV88 E5RJ88 INTS9 Integrator complex subunit 9 1 42575500.0 14689000.0 21025000.0 6861500.0 True False 19015200.06347795 19854940.2675396 5612777.404935364 1.0 1.0441615234790258 0.2951731975576578 24.18064978220024 -6.892899560780226 1.0050537894803373 1.0374913627716769 0.2269665226543825 0.9826908328568528 0.045145168795241275 0.11682278426068032 0.2083489802186614 0.034087861499513296 0.08592001736660888 1.2796772206970594e-07 6.892899560780226 -0.8105248401172944 down LSNLYK(ub)SAADDSEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSNLYKSAADDSEAK 15 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 8789500.0 3802400.0 2915500.0 2071600.0 True False 3681694.893328532 4079674.354131643 1528985.813332143 1.0 1.108096806588801 0.41529400388466836 21.811938643018966 -6.867039704659219 1.1497255285010082 1.0601602760647688 0.37695331052054415 0.9616337406191796 0.05960972935310395 0.13972028253266178 0.3470564381166831 0.040307391362999996 0.09496308300336036 1.3581892706891445e-07 6.867039704659219 -0.6832069655442247 down LSNQGDQK(ub)GSTYSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSNQGDQKGSTYSR 14 1 Q9UKT4-2;Q9UKT4 Q9UKT4-2 FBXO5 F-box only protein 5 1 17266800.0 3883500.0 5340000.0 8043300.0 True False 3760220.418220426 7472289.847732111 5936518.436172242 1.0 1.9871946366560265 1.578768735844953 21.84238580222526 -10.173545742863226 4.7793586147606355 0.9999121358686898 1.7829816862542658 0.8305147342660661 0.16673917580036296 0.0001561307219416513 2.6997903230566396e-05 0.16146247441132897 0.05381483758440568 6.705856523181569e-11 10.173545742863226 0.783069550385576 LSNTQGVVSAFSTMMSVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSNTQGVVSAFSTMMSVHR 19 0 P48047;A0A494C0K9;H7C0C1;H7C068 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 42722100.0 9606100.0 16848000.0 16268000.0 False True 12593690.125604723 14334344.07298963 14584743.413674975 1.0 1.1382163551766227 1.158099275765263 23.586197738838862 -13.855940784365684 0.27455419651886714 1.9616915727686322e-14 1.164454773033261 0.9995857756205133 0.001431021209993171 13.971948239937957 0.16543408139441973 7.795821649065933 0.008080829623950285 1.393346771484283e-14 13.855940784365684 1.1644547730332415 LSNTQGVVSAFSTMMSVHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSNTQGVVSAFSTMMSVHR 19 0 P48047;A0A494C0K9;H7C0C1;H7C068 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 65383000.0 20652000.0 11171000.0 33560000.0 False True 19996413.564333275 15631638.555995421 24769629.22158078 1.0 0.7817221076021796 1.2387035876153953 24.25323793436535 -6.77680125383852 1.5481578330092105 0.8758928441222735 1.2419782004614497 0.7559702258595699 0.09219108834009099 0.25557512921509334 1.209654963046387 0.04691133304485124 0.11099877662472805 1.6718555304337448e-07 6.77680125383852 0.36608535633917616 LSNTQGVVSAFSTMMSVHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSNTQGVVSAFSTMMSVHR 19 0 P48047;A0A494C0K9;H7C0C1;H7C068 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 71502000.0 12162000.0 31874000.0 27466000.0 False True 18450643.1612984 26185835.667301334 22037333.061224535 1.0 1.4192370118689452 1.1943937600749595 24.137167771523938 -10.132449743126006 4.255014004276956 0.9999465293531885 1.306815385807002 0.7128707153323081 0.09179187341887793 64100361.4226932 4.726075598183159 39210.62168808702 0.031422799753110575 7.371404728352971e-11 10.132449743126006 0.30686885645381345 LSNTQGVVSAFSTMMSVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSNTQGVVSAFSTMMSVHR 19 0 P48047;A0A494C0K9;H7C0C1;H7C068 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 57352100.0 9606100.0 18689000.0 29057000.0 False True 13157734.76509151 17863258.18374159 22194335.047699705 1.0 1.3576241277589967 1.6867899713697676 23.649407800361754 -6.972118411288482 0.20125645266469083 0.8072210362245767 2.2462937008028665 0.9999945324962943 0.000655768084819459 0.07562111989262016 0.006508364757205652 0.010577248382235987 0.0348347008295749 1.0663053512337234e-07 6.972118411288482 1.4390726645782896 LSNTQGVVSAFSTMMSVHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSNTQGVVSAFSTMMSVHR 19 0 P48047;A0A494C0K9;H7C0C1;H7C068 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 45373000.0 20652000.0 10042000.0 14679000.0 False True 17173053.038725607 9987901.752819065 17748311.031972427 1.0 0.5816031506043876 1.0334977124888394 24.033643209799628 -11.93327676150471 17.86806479322542 0.898293951520433 0.8267953885989568 0.0 0.21043203311667302 0.0 0.0 0.0 0.06120713525637752 1.1660662847715314e-12 11.93327676150471 -0.07149856292147616 LSNTQGVVSAFSTMMSVHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSNTQGVVSAFSTMMSVHR 19 0 P48047;A0A494C0K9;H7C0C1;H7C068 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 76129000.0 12162000.0 38347000.0 25620000.0 False True 15743948.748860953 36212955.74027787 20957422.883399237 1.0 2.300119005589231 1.3311414574387173 23.908294093616387 -10.161622552299027 4.732192606102017 0.9999120714833277 1.8156302315196964 0.4857841819113903 0.39558342754995757 0.0003670101048278633 6.502065307696581e-05 0.38306293661490515 0.12767400224193448 6.892510679680899e-11 10.161622552299027 0.8157181600363687 LSNVNLQEK(ub)AYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSNVNLQEKAYR 12 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 26676500.0 5418700.0 6889800.0 14368000.0 True False 7103968.174765438 5861868.696230052 12881337.187588021 1.0 0.8251541324540916 1.8132594165250948 22.760193687863133 -6.861181918447597 1.179644043140165 0.9048120834286962 1.862223720084727 0.9550675669470808 0.09126360306884927 0.1455950100082172 0.384300759618842 0.06030849170197808 0.1409805425431783 1.3766327004730603e-07 6.861181918447597 0.9574116366560307 LSNVNLQEK(ub)AYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSNVNLQEKAYR 12 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 39573800.0 5938600.0 6352200.0 27283000.0 True False 5750082.3936252985 8888666.586285386 20136763.82754431 1.0 1.5458329077405237 3.501995701812636 22.455151198080834 -6.947400843037998 0.5866850278231278 0.9771561149393836 4.1685449936690135 0.9989812102362249 0.03428574489368975 0.08454652956272568 0.040413377917319075 0.03566787756822851 0.16371751662454354 1.1287536221371359e-07 6.947400843037998 3.19138887872963 LSNVNLQEK(ub)AYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSNVNLQEKAYR 12 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 106040000.0 15418000.0 32236000.0 58386000.0 True False 23390233.206783347 26483233.938982405 46845981.50850708 1.0 1.1322347111657725 2.002800959458642 24.47940291002298 -6.9339042470793855 0.7140190080038185 0.9884850226966614 2.2006944401315143 0.9972514752259791 0.02332159498611377 0.09066057014208105 0.06811662588719937 0.02176410279571782 0.07715011061159446 1.1643827233383901e-07 6.9339042470793855 1.212209417434853 up LSNVNLQEK(ub)AYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSNVNLQEKAYR 12 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 33471800.0 5418700.0 6188100.0 21865000.0 True False 7422139.824861425 5914689.280689776 16700937.323810235 1.0 0.7968981210617662 2.2501512660632272 22.823403749386024 -6.871529878490955 1.1259234090350596 0.8839891495992706 2.337790333900784 0.9661887335024135 0.11815486221635631 0.13539888118823842 0.3198640882525412 0.08136167414753603 0.19316246394415024 1.344219284203761e-07 6.871529878490955 1.4538011843015135 up LSNVNLQEK(ub)AYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSNVNLQEKAYR 12 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 37235600.0 5938600.0 12476000.0 18821000.0 True False 4938209.024587254 12408789.311707888 22756384.081528246 1.0 2.512811679279826 4.608226174352811 22.23555647351511 -6.966547597564957 0.3304158319311164 0.7459464040274745 6.443730349133741 0.9999415838473028 0.011307418741855918 0.07743965319662915 0.013029114433131362 0.03053027727065222 0.18270557961838987 1.0800712413480771e-07 6.966547597564957 5.697783945106266 LSNVNLQEK(ub)AYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSNVNLQEKAYR 12 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 113102000.0 15418000.0 21998000.0 75686000.0 True False 19958904.93421628 20773791.962203883 61911924.60394056 1.0 1.0408282433667295 3.1019700132847814 24.25052923211543 -6.911183405378852 0.8876174468734488 0.9385462338865982 3.3752104500214477 0.9913609684454543 0.09121725432304736 0.10364122314621307 0.13455372712617586 0.07512044525774371 0.20911215060767538 1.2269209850404417e-07 6.911183405378852 2.4366642161348495 up LSNWEPK(ub)DDAMSEHRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSNWEPKDDAMSEHRR 16 2 E9PMH5;Q13490-2;Q13490;A0A087X2B2;H0YDY3 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 60566100.0 5546700.0 21670400.0 33349000.0 True False 8414749.41808699 17803147.80839201 26757555.53261406 1.0 2.115707423221092 3.1798398506199512 23.004488879659444 -6.971700195967988 0.2137098017693232 0.4685691823873158 4.856809585974258 0.9999927814705994 0.0023911816933672794 0.07575476785802596 0.007021151847952472 0.030947036174626453 0.10934287644809812 1.0673326726460401e-07 6.971700195967988 4.388240403586942 LSNWEPK(ub)DDAMSEHRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSNWEPKDDAMSEHRR 16 2 E9PMH5;Q13490-2;Q13490;A0A087X2B2;H0YDY3 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 79631300.0 5546700.0 17261600.0 56823000.0 True False 7180312.491802923 16300976.785834093 46481797.05321601 1.0 2.27023222240583 6.473506147020737 22.775615201751894 -6.949227997525839 0.5672550556791189 0.9469742733217382 8.000163365963067 0.9991393045573185 0.06862205399830573 0.08379721572522665 0.0372566846961835 0.07293056403719582 0.3499832405791187 1.1240147296297754e-07 6.949227997525839 7.053189092641328 LSPATENK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSPATENKLR 10 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 22743500.0 1853000.0 2648500.0 18242000.0 True False 2811136.472445812 2175854.4821750512 14636460.704247363 1.0 0.7740123980113859 5.206599127331943 21.42272206336315 -6.89489084149541 0.9930136386988896 0.788997451504115 5.626455942028989 0.983848101377044 0.2590560001477282 0.11526403643993018 0.19939109310532335 0.19738925535553806 0.501591485585433 1.2738232121016528e-07 6.89489084149541 4.837458490524874 up LSPATENK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSPATENKLR 10 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 5505900.0 1414500.0 1538700.0 2552700.0 True False 1937478.8754251949 1470715.1461995402 1949804.834506762 1.0 0.7590870614662988 1.006361854695764 20.885749149912105 -11.048905459772147 10.346495380661779 1.3760170709447408 0.8827244580810314 0.23071719480091057 0.10094951161073439 0.04677006229333901 0.00022107136534908807 0.005220978091510465 0.03258131477301221 8.93499965819416e-12 11.048905459772147 -0.4932926128637094 LSPATENK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSPATENKLR 10 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 12616800.0 1853000.0 2152600.0 8611200.0 True False 2398745.028090723 2032805.9177125215 7044049.958373443 1.0 0.8474455992225777 2.9365563558792003 21.1938483854556 -6.889331939946504 1.02630552150885 0.8859455338617307 3.113919020290221 0.9804679959502789 0.13289496039946755 0.11968771486840683 0.22501678291257277 0.09874724982895648 0.24559878881530356 1.290232745993127e-07 6.889331939946504 2.2279734864284904 up LSPEELLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSPEELLLR 9 0 P13796;P13797;A0A0A0MSQ0;P13797-2;P13797-3;Q14651;C9JAM8 P13796;P13797;Q14651 LCP1;PLS3;PLS1 Plastin-2;Plastin-3;Plastin-1 0 18178200.0 1619900.0 9627300.0 6931000.0 False True 2123704.587133914 8190944.366921478 6213846.606846654 1.0 3.8569132526928906 2.9259467839793425 21.018151666766776 -10.377988201409714 5.809830472968658 0.9994180651500782 3.391430018336119 0.8979387881485825 0.3800654693315003 0.0028653474813477475 0.00030676871459488724 0.36806379403090134 0.12266560276578167 4.1880494274534585e-11 10.377988201409714 2.392011953186041 LSPEELLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSPEELLLR 9 0 P13796;P13797;A0A0A0MSQ0;P13797-2;P13797-3;Q14651;C9JAM8 P13796;P13797;Q14651 LCP1;PLS3;PLS1 Plastin-2;Plastin-3;Plastin-1 0 18454200.0 7372900.0 5070000.0 6011300.0 False True 7138851.3252214175 7094477.439700722 4436760.194865563 1.0 0.9937841700997577 0.6214949706531328 22.76726052583007 -6.910525743336745 0.8921492473438702 1.0113360196335763 0.5728382292951764 0.9911184083796769 0.01667917993571648 0.10407131397804326 0.1368899084864573 0.01369106509643834 0.03793251038700403 1.2287803469613026e-07 6.910525743336745 -0.4384977903384 LSPEELLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSPEELLLR 9 0 P13796;P13797;A0A0A0MSQ0;P13797-2;P13797-3;Q14651;C9JAM8 P13796;P13797;Q14651 LCP1;PLS3;PLS1 Plastin-2;Plastin-3;Plastin-1 0 22634200.0 1619900.0 13548000.0 7466300.0 False True 2218820.806151481 12949404.562755134 5702913.713275295 1.0 5.836165104840407 2.5702452841006718 21.081361728289668 -10.148905173986869 10.651498318345089 0.9999999972449749 4.20320519447054 0.5619064849460667 1.3333061836090427 9.098246259528095e-08 7.224119802255306e-09 1.2909681611282915 0.4303227203760992 7.097327176113998e-11 10.148905173986869 3.203205197225565 LSPFFTLDLSPTEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSPFFTLDLSPTEDK 15 0 G3V174;A7KAX9-2;A7KAX9 G3V174 ARHGAP32 Rho GTPase-activating protein 32 0 16664930.0 981930.0 8389600.0 7293400.0 False True 1287319.7390236459 7137904.382404658 6538748.931232914 1.0 5.544779720241318 5.07935109904565 20.29593899787341 -10.471587806045317 4.871556950573583 0.988505370566226 5.312065409643878 0.991337993455028 0.19001043893769265 0.023391293562115136 0.0025372237018872583 0.18141581581808663 0.06132560546737463 3.376075839392192e-11 10.471587806045317 4.323560039077653 LSPFFTLDLSPTEDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSPFFTLDLSPTEDK 15 0 G3V174;A7KAX9-2;A7KAX9 G3V174 ARHGAP32 Rho GTPase-activating protein 32 0 14805200.0 5266500.0 1707800.0 7830900.0 False True 5099317.840236352 2389733.4460593476 5779752.368035656 1.0 0.46863786901123705 1.133436382888376 22.281872833205902 -6.693833014527628 1.8526883066525508 0.6680745402894486 1.1312572371258884 0.3884549615269035 0.22455696970324404 0.4084913104586165 2.7213311260491295 0.09685498752562034 0.2510153251557481 2.0237971755909135e-07 6.693833014527628 0.46318269683643987 LSPFFTLDLSPTEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSPFFTLDLSPTEDK 15 0 G3V174;A7KAX9-2;A7KAX9 G3V174 ARHGAP32 Rho GTPase-activating protein 32 0 19745530.0 981930.0 9944200.0 8819400.0 False True 1344976.0566604873 9504832.362928092 6736439.361244538 1.0 7.066915664304201 5.008594262986957 20.3591490593963 -9.704662742854627 8.015030616913412 0.9999999997971619 6.0377549636455905 0.8887287895608794 0.8403061933129922 0.0 6.050595423812118e-09 0.8136229670420588 0.2712076577013407 1.9739550420646273e-10 9.704662742854627 5.037754963848428 LSPGGYFIGTTPNSFELIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSPGGYFIGTTPNSFELIR 19 0 K7EP06;O43148;O43148-2 K7EP06 RNMT mRNA cap guanine-N7 methyltransferase 0 2172900.0 479640.0 1021900.0 671360.0 False True 628812.6848403679 869436.5033350002 601894.1073398599 1.0 1.3826637475605599 0.9571914209915444 19.26227079535984 -6.669727274409606 1.938466678912939 1.2443138911450795 0.9589188750461094 0.2777615054308099 0.16255819647449515 0.46175847541069326 3.3449443390676454 0.06751954005418113 0.18045109762628936 2.1393050954907638e-07 6.669727274409606 -0.2853950160989701 LSPGGYFIGTTPNSFELIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSPGGYFIGTTPNSFELIR 19 0 K7EP06;O43148;O43148-2 K7EP06 RNMT mRNA cap guanine-N7 methyltransferase 0 3565340.0 479640.0 1266200.0 1819500.0 False True 656975.8697836272 1210255.097236535 1389771.5737787643 1.0 1.8421606529249368 2.115407334878952 19.32548085688273 -10.56517285523501 0.23777637141567223 2.2009027185675327e-10 2.272762655976459 0.9992089136925426 0.013351437366491158 2.2627263347438236 0.11993473574483829 1.4642937178226487 0.1328663844057877 2.7216178507759366e-11 10.56517285523501 2.272762655756369 LSPGSDIYVTVSSMALARSQCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSPGSDIYVTVSSMALARSQCR 22 1 F5GYF8;O43166-3;O43166-2;O43166 F5GYF8 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 0 58313000.0 14512000.0 13154000.0 30647000.0 False True 14051324.50346717 18406460.797203783 22619631.30970757 1.0 1.3099448947081096 1.609786415802024 23.744202792132512 -6.9715301994930226 0.21857084269502206 0.8592066246070781 2.0689773424222206 0.9999919835213513 0.0007048541179982771 0.07580923950507333 0.00722680420529151 0.008396980399752329 0.030483169351785685 1.0677505418922762e-07 6.9715301994930226 1.2097707178151427 LSPGSDIYVTVSSMALARSQCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSPGSDIYVTVSSMALARSQCR 22 1 F5GYF8;O43166-3;O43166-2;O43166 F5GYF8 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 0 41698000.0 12439000.0 16595000.0 12664000.0 False True 18870872.412711 13633492.592673214 10160954.849171612 1.0 0.7224622314488226 0.5384464812727694 24.169657785422167 -8.347713060252149 0.10916993058701067 1.5132244262602195 5.893287205596371e-15 0.9999759125458169 0.0009310760836783718 0.09839309215652578 0.023945886904443124 0.15893630902584172 0.15379276363277042 4.490419754086545e-09 8.347713060252149 -1.5132244262602135 LSPGSDIYVTVSSMALARSQCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSPGSDIYVTVSSMALARSQCR 22 1 F5GYF8;O43166-3;O43166-2;O43166 F5GYF8 SIPA1L1 Signal-induced proliferation-associated 1-like protein 1 0 38358800.0 14512000.0 14274000.0 9572800.0 False True 12067370.990605539 14197103.128832823 11574428.220373712 1.0 1.1764868370985928 0.9591507735516226 23.52460806756679 -6.690712296805112 1.8636310607318283 1.1105727834179584 0.9598910257411675 0.3738004437351915 0.07463097585949696 0.4151820615867827 2.796230026557468 0.03202770574585822 0.0833353577943944 2.0383919858977785e-07 6.690712296805112 -0.15068175767679093 LSPSAASDAVLSALLSIFSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSPSAASDAVLSALLSIFSR 20 0 Q8N201 Q8N201 INTS1 Integrator complex subunit 1 0 148574000.0 56901000.0 41003000.0 50670000.0 False True 86322977.02031246 33685694.292098805 40655052.29055003 1.0 0.3902285979336915 0.4709644372086888 26.36324128411602 -10.65020546484447 6.644355832386396 1.002699359694193 0.43059651757185813 0.9851456311709648 0.032960268363182846 0.0013219609529805155 6.959508618644558e-05 0.0320102289849811 0.010637880871427864 2.237662249453029e-11 10.65020546484447 -0.572102842122335 LSPTEPK(ub)NYGSYSTQASAAAATAELLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSPTEPKNYGSYSTQASAAAATAELLK 27 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 20407300.0 8389300.0 7644800.0 4373200.0 True False 10998453.542096773 6504225.63919701 3920703.2146965424 1.0 0.5913763798066676 0.35647768112944084 23.390797349416722 -9.219534353546186 0.1575800005297958 1.523605144256328 1.0197909483114896e-22 0.9997876577146078 0.0038745189448980842 0.6593427121020807 0.055919425500689644 0.3333295229518518 0.1718712381114844 6.032059912611905e-10 9.219534353546186 -1.523605144256328 LSPTEPK(ub)NYGSYSTQASAAAATAELLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSPTEPKNYGSYSTQASAAAATAELLK 27 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 28166200.0 14187000.0 6487400.0 7491800.0 True False 13736641.450571178 9077852.65134408 5529472.830817598 1.0 0.6608495012415584 0.40253455334875027 23.71152597878295 -7.671094561245294 0.18715272416377704 1.2379301637977265 3.3201757043609995e-10 0.9999382618797108 0.001922351824534624 0.1330215528559142 0.022348172062532413 0.04794560438842499 0.08123026818892809 2.1325805245018255e-08 7.671094561245294 -1.237930163465709 down LSPTEPK(ub)NYGSYSTQASAAAATAELLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSPTEPKNYGSYSTQASAAAATAELLK 27 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 17748600.0 8389300.0 6576800.0 2782500.0 True False 11491050.922307944 6286215.229430764 2125330.8073863205 1.0 0.5470531174156694 0.18495530319688586 23.454007410939614 -7.9549153502282275 0.33150574869830884 1.0965004583105555 3.444876379038339e-20 0.9988553230693273 0.011280923798284803 0.10269222635700725 0.06362070962640243 0.0503005860466222 0.08611878287314144 1.1093910292596218e-08 7.9549153502282275 -1.0965004583105555 down LSPYEWYNPHPCLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSPYEWYNPHPCLR 14 0 Q16478;Q16478-2 Q16478 GRIK5 Glutamate receptor ionotropic, kainate 5 0 16933400.0 4993000.0 3776500.0 8163900.0 False True 6545871.352280783 3213060.9206817048 7319177.94165854 1.0 0.49085305038299837 1.118136539470534 22.642153818323052 -6.6907977991661 1.863419942882518 0.6810395232034075 1.1159993728789395 0.37423548748917523 0.21529806851451216 0.41495601013877403 2.7941640602620144 0.09240516455628942 0.24040204450310557 2.0379907139975675e-07 6.6907977991661 0.4349598496755319 LSPYEWYNPHPCLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSPYEWYNPHPCLR 14 0 Q16478;Q16478-2 Q16478 GRIK5 Glutamate receptor ionotropic, kainate 5 0 15091000.0 1327500.0 2080500.0 11683000.0 False True 1285359.2391367606 2911254.499664175 8622871.81751276 1.0 2.264934510930466 6.708530623161684 20.293740197295506 -6.94785964496061 0.5818670567395283 0.9472469820504872 8.246711678049607 0.9990224388307059 0.0765381063185991 0.08435675305738202 0.03960827157222141 0.08003087138169881 0.37138988782884047 1.1275618020686074e-07 6.94785964496061 7.29946469599912 LSPYEWYNPHPCLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSPYEWYNPHPCLR 14 0 Q16478;Q16478-2 Q16478 GRIK5 Glutamate receptor ionotropic, kainate 5 0 10711000.0 4993000.0 2148800.0 3569200.0 False True 6839047.0307514975 2053858.9108686342 2726228.4699814073 1.0 0.30031361118494154 0.3986269516385882 22.705363879845944 -10.801488192225609 7.265745633825184 1.0234925868372926 0.3494702814117658 0.9831587034647495 0.040136253169992996 0.013707515405893574 0.00037451080657103413 0.03487638657238015 0.012953920008878952 1.579471550467447e-11 10.801488192225609 -0.6740223054255268 LSQAYAISAGVSLEGQQLFQTIHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSQAYAISAGVSLEGQQLFQTIHK 24 0 Q3MHD2-2;Q3MHD2;K7ELG9 Q3MHD2-2 LSM12 Protein LSM12 homolog 0 76610000.0 22876000.0 32208000.0 21526000.0 False True 34704564.45961707 26460230.757747438 17271376.664819054 1.0 0.7624423809881578 0.4976687341780755 25.048622087539172 -6.969723721955055 0.2647085995907285 1.0701894924597266 0.18201756537237762 0.9999801437830133 0.0009142533261045211 0.07639250618764289 0.009350776659159449 0.0053636140181343205 0.024809523137534983 1.072201173080008e-07 6.969723721955055 -0.8881719270873489 down LSQGVTLVVDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSQGVTLVVDR 11 0 P23919;H7BZ20;P23919-2 P23919;P23919-2 DTYMK Thymidylate kinase 0 5859300.0 0.0 2099400.0 3759900.0 False True 0.0 2937701.3682263712 2775069.3954178044 0.0 LSQGVTLVVDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSQGVTLVVDR 11 0 P23919;H7BZ20;P23919-2 P23919;P23919-2 DTYMK Thymidylate kinase 0 11066700.0 2034500.0 2661800.0 6370400.0 False True 2786709.6302951975 2544192.874604489 4865842.722506316 1.0 0.912973797824419 1.7460888890640807 21.41013125358956 -6.881101998117433 1.0736022763413535 0.9452309236838223 1.8064008949793176 0.9745648552473408 0.05963324694343674 0.12665984891421556 0.266408132275734 0.04274332009582491 0.10366261098900932 1.314915975620342e-07 6.881101998117433 0.8611699712954952 LSQLLK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSQLLKK 7 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 18528000.0 4384100.0 5381500.0 8762400.0 True False 5747597.555684796 4578601.176922708 7855750.9028759245 1.0 0.7966113028206255 1.366788615028554 22.454527617767972 -6.810242377022463 1.4133807316266387 0.8891862398882806 1.3768321093438194 0.8604950029276737 0.08812391795835428 0.2064675741786505 0.8128357171614168 0.049023867329305595 0.11339692295343032 1.5479524752448886e-07 6.810242377022463 0.4876458694555388 LSQLLK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSQLLKK 7 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 17266700.0 4144200.0 7135100.0 5987400.0 True False 6287054.381602767 5861785.658209254 4803987.765629349 1.0 0.9323580332567286 0.7641078753329731 22.583952811481314 -6.955570172457748 0.493924177230091 1.003554416460775 0.6857292646128113 0.9995689965375264 0.0020590141381861093 0.08132317697880494 0.0272800837359309 0.0024432066852509374 0.013877129017459005 1.1077195677402263e-07 6.955570172457748 -0.3178251518479638 LSQLLK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSQLLKK 7 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 17583000.0 4384100.0 4498000.0 8700900.0 True False 6005020.245847717 4299263.487103094 6645926.620660439 1.0 0.7159448779670476 1.1067284286436652 22.517737679290864 -6.7117895819674676 1.788943238287971 0.8256854446947357 1.1058539082059817 0.47350271604623906 0.11966680504463288 0.3715114882694825 2.318779239557445 0.05321168845844065 0.1348841958029341 1.9418264751737053e-07 6.7117895819674676 0.280168463511246 LSQLLK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSQLLKK 7 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 31346200.0 5915000.0 18328000.0 7103200.0 True False 4918584.578929978 18229263.426176835 8588446.278513977 1.0 3.706201069361818 1.746121499120864 22.22981178026542 -9.464572291187809 8.82105239140482 0.9999795010982765 2.726161284241371 0.508377215379533 0.8001991338116187 0.0 0.0 0.7747894796859156 0.2582631598953052 3.4310552286016563e-10 9.464572291187809 1.7261817831430948 LSQLLK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSQLLKK 7 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 12322700.0 4144200.0 6179900.0 1998600.0 True False 5364748.594394801 5835983.132431307 1634875.3073677493 1.0 1.0878390719984272 0.30474406742487437 22.355079133573764 -6.8790373494550545 1.0851203685321105 1.053782187962197 0.25025361939592444 0.9729020857053406 0.057662963211304534 0.12848780006920574 0.27744919433853305 0.04096856067438953 0.09883744577036627 1.3211820072537528e-07 6.8790373494550545 -0.8035285685662725 down LSQMK(ub)PTYLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSQMKPTYLTR 11 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 15497000.0 1896600.0 1897400.0 11703000.0 True False 1836393.4711463521 2655041.7148102825 8637633.217525616 1.0 1.4457913059083665 4.703585235539773 20.808443777342283 -6.931819991678005 0.7316984242964822 0.9536518517445601 5.404484964399284 0.996884017864432 0.09215346573746333 0.09170373735906308 0.07313080634402262 0.08488414425523147 0.29187996388293364 1.1699842308378094e-07 6.931819991678005 4.450833112654724 up LSQMK(ub)PTYLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSQMKPTYLTR 11 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 10502300.0 853100.0 1866100.0 7783100.0 True False 1168514.1241606448 1783649.5316325186 5944892.077976092 1.0 1.5264253077931185 5.087565443204519 20.15624374181322 -6.933352362486548 0.7187404382130095 0.9520018278575517 5.8852476225489525 0.9971570972681372 0.09680478149445829 0.0909340842156088 0.06942362301368 0.09002338463209572 0.31649206655662215 1.1658633163085179e-07 6.933352362486548 4.933245794691401 up LSQMK(ub)PTYLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSQMKPTYLTR 11 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 13712400.0 1896600.0 2878000.0 8937800.0 True False 1577106.9336261363 2862495.642761728 10806652.656281987 1.0 1.8150295212894558 6.852200333324878 20.58884905277656 -6.935211094008068 0.7026996892906001 0.9361607204598249 8.038399227417175 0.9974669863428822 0.13025798220022547 0.09002078713246818 0.0650762673234313 0.12259398835210074 0.443447662977113 1.1608842150790185e-07 6.935211094008068 7.10223850695735 LSQNK(ub)QALEGLGDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSQNKQALEGLGDLK 15 1 B3KWE1;P12081-3;P12081-2;P12081-4;P12081;E7ETE2;B4E1C5;B4DDD8;D6RJE6;B4DQ67;D6RB22;A0A2R8Y6I1;A0A2R8Y3N3;A0A2R8Y5P7;P49590-2;P49590 B3KWE1 HARS;HARS2 Histidine--tRNA ligase, cytoplasmic;Probable histidine--tRNA ligase, mitochondrial 1 4538700.0 2232900.0 0.0 2305800.0 True False 1856755.2842422244 0.0 2787932.1191853713 1.0 0.0 1.501507572293339 20.82435225348565 -6.727145709211938 1.733327236618151 0.3963179298298315 1.500215638078119 0.5461490569509777 0.4204781954892899 0.3416002140937132 2.009229702796974 0.19233174939837364 0.47886473210642083 1.8743655381918468e-07 6.727145709211938 1.1038977082482875 LSQNK(ub)QALEGLGDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSQNKQALEGLGDLK 15 1 B3KWE1;P12081-3;P12081-2;P12081-4;P12081;E7ETE2;B4E1C5;B4DDD8;D6RJE6;B4DQ67;D6RB22;A0A2R8Y6I1;A0A2R8Y3N3;A0A2R8Y5P7;P49590-2;P49590 B3KWE1 HARS;HARS2 Histidine--tRNA ligase, cytoplasmic;Probable histidine--tRNA ligase, mitochondrial 1 49728300.0 6348200.0 7699100.0 35681000.0 True False 8217870.041729912 7270638.316947166 29187424.117976937 1.0 0.884735129665868 3.5517018363352952 22.97033308507746 -6.89679939266194 0.9812908228529245 0.879171397111668 3.814129663327821 0.9849052415186269 0.1512356267313893 0.11379932109987932 0.19100879245269164 0.11625149740161157 0.29788704292777707 1.268237549118059e-07 6.89679939266194 2.934958266216153 up LSQSLLELWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSQSLLELWR 10 0 H7BXY3;Q7L2E3-3;Q7L2E3;Q7L2E3-2 H7BXY3 DHX30 Putative ATP-dependent RNA helicase DHX30 0 3400780.0 611080.0 1515600.0 1274100.0 False True 801131.7977071379 1289478.3877625281 1142268.3540302 1.0 1.6095708489577523 1.425818270226453 19.611680080687435 -10.14835550305651 4.397437998766268 0.999922554390615 1.5176945596028606 0.9136684414551689 0.07501667675615974 52468092.692587286 9.026572692954021 49467.117884529755 0.025680203681960223 7.106315695280944e-11 10.14835550305651 0.5177720052122456 LSQSLLELWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSQSLLELWR 10 0 H7BXY3;Q7L2E3-3;Q7L2E3;Q7L2E3-2 H7BXY3 DHX30 Putative ATP-dependent RNA helicase DHX30 0 4023580.0 611080.0 1036300.0 2376200.0 False True 837012.7898160673 990512.8394141702 1814990.499375159 1.0 1.1833903274427078 2.16841429600377 19.674890142210327 -6.938221961283773 0.6759101364295075 0.9885295601074686 2.4206964733125136 0.9979215175325601 0.02339070235925068 0.0885873576362201 0.058375950643868905 0.02247323512549479 0.08546455996184558 1.1528638960787085e-07 6.938221961283773 1.432166913205045 up LSQTSNVDK(ub)EEEAVTIEMNEPVQLTFALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSQTSNVDKEEEAVTIEMNEPVQLTFALR 29 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 37059000.0 11052000.0 12518000.0 13489000.0 True False 16766692.009428563 10284065.096419593 10822893.237561272 1.0 0.6133627963486455 0.6454996150388603 23.999094744148376 -9.872943832973828 5.493660467318075 1.0000002383444755 0.6294312062103505 0.9943909849845781 0.013119801298998318 4221147.789442048 7586043.116751326 8.034517413824695 0.004491257708699594 1.3398499581550054e-10 9.872943832973828 -0.37056903213412495 LSQTSNVDKEEEAVTIEMNEPVQLTFALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSQTSNVDKEEEAVTIEMNEPVQLTFALR 29 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 151009000.0 36119000.0 68936000.0 45954000.0 False True 54795163.652601324 56633832.2005737 36871171.75764624 1.0 1.0335553071732653 0.6728909870843288 25.70754522742802 -6.884133437997204 1.0565027334818229 1.0221910303921007 0.6452179631351647 0.9768684740130457 0.02474322632838517 0.12403059909500383 0.2507079640454579 0.017968797405345422 0.04394642595116739 1.3057696257134076e-07 6.884133437997204 -0.376973067256936 LSQVPDNPPDYQK(ub)YYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSQVPDNPPDYQKYYR 16 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 283533300.0 72157000.0 116753300.0 94623000.0 True False 94598525.76938199 99334162.74079886 84832319.64790802 1.0 1.050060367568113 0.8967615399706903 26.495314364882187 -6.818742249441184 1.3772114153425365 1.0270171171682152 0.8935016026275396 0.8814909894395693 0.021972465214461688 0.19511770442020185 0.7275143826247872 0.012538147323771407 0.028909903085424165 1.5179509928486322e-07 6.818742249441184 -0.13351551454067556 LSQVPDNPPDYQK(ub)YYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSQVPDNPPDYQKYYR 16 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 349689400.0 114146400.0 126163000.0 109380000.0 True False 110522885.01258044 176540543.8313536 80730096.67033674 1.0 1.597321168473467 0.7304378334057016 26.719769885962183 -6.7213060329687275 1.7545490657489506 1.3628995413503453 0.7316864376046874 0.5186562955004388 0.25131642416670474 0.3528113153668332 2.1232933791939295 0.11369935563936603 0.2849975927957156 1.8997391247713387e-07 6.7213060329687275 -0.6312131037456579 LSQVPDNPPDYQK(ub)YYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSQVPDNPPDYQKYYR 16 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 503072000.0 189751700.0 85594000.0 227726300.0 True False 287867201.6074451 70319081.95102562 182716096.98901698 1.0 0.2442761160645088 0.6347235668694928 28.1008281826866 -10.728155120015538 6.731415608021131 1.0082922974414892 0.4394998414732317 0.7331677487228703 0.15939950430710798 0.019802777812132407 0.0007997243210570037 0.15407374102633223 0.05144596879792887 1.8700140949770615e-11 10.728155120015538 -0.5687924559682576 LSQVPDNPPDYQK(ub)YYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSQVPDNPPDYQKYYR 16 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 249516000.0 72157000.0 87047000.0 90312000.0 True False 98835392.86960457 83200975.71406461 68982165.63402468 1.0 0.8418135780957865 0.6979500321816312 26.55852442640508 -6.972257190988342 0.1969684857305546 1.089053352414618 0.4467512304103682 0.9999950462360601 0.0002744969196498803 0.07557695165659185 0.006336295262180686 0.0047894211090374825 0.01539206032232231 1.0659646655898022e-07 6.972257190988342 -0.6423021220042497 LSQVPDNPPDYQK(ub)YYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSQVPDNPPDYQKYYR 16 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 321371200.0 114146400.0 134070800.0 73154000.0 True False 94917789.14292021 133348533.98942977 88450163.17412022 1.0 1.4048845342219611 0.9318607604833534 26.50017516139646 -6.680097796925594 1.9016826211479396 1.2561543134578785 0.9336658059519775 0.32452260516194575 0.17159619872098963 0.4382974828003255 3.064679610332689 0.07240481458735211 0.19092893321504528 2.0888257041211232e-07 6.680097796925594 -0.3224885075059011 LSQVPDNPPDYQK(ub)YYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSQVPDNPPDYQKYYR 16 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 313891700.0 189751700.0 124140000.0 0.0 True False 245637316.2151982 117231499.87216963 0.0 1.0 0.4772544403207261 0.0 27.87195450477905 -8.00108786864812 0.5792642870419343 1.0143857329830366 4.082847157705581e-17 0.9895807662350842 0.041686170568733714 0.11182804857946184 0.16477144821957898 0.04629951722267864 0.07617947714118084 9.97498224537186e-09 8.00108786864812 -1.0143857329830366 LSRLEEQLKEK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSRLEEQLKEK 11 2 Q15075 Q15075 EEA1 Early endosome antigen 1 1 16538400.0 2726900.0 5049500.0 8762000.0 True False 3574992.307337161 4296134.28279684 7855392.291038851 1.0 1.201718469150168 2.1973172571355692 21.769508706829615 -6.94009589136417 0.6586804743107253 0.9888428482874758 2.4665489659452327 0.9981763153399479 0.02235136158454821 0.0877230910207567 0.05441265914583079 0.02177308771636753 0.08565314570492225 1.1479001394292723e-07 6.94009589136417 1.4777061176577568 up LSRLEEQLKEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSRLEEQLKEK 11 2 Q15075 Q15075 EEA1 Early endosome antigen 1 1 30504200.0 6598200.0 11807000.0 12099000.0 True False 6388743.752672074 16521596.67269158 8929908.93778027 1.0 2.5860477915993214 1.3977566300174993 22.607100844789585 -6.572494827951523 2.295863121595343 2.0848979927931928 1.4002918478564423 0.0 0.6903347794859849 0.7224201016907298 7.151097674389593 0.2536404297460422 0.7735552691106031 2.6761174631111296e-07 6.572494827951523 -0.6846061449367504 LSRLEEQLKEK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSRLEEQLKEK 11 2 Q15075 Q15075 EEA1 Early endosome antigen 1 1 39835000.0 10383000.0 14977000.0 14475000.0 True False 15751770.098977277 12304237.334164886 11614009.905382132 1.0 0.7811336285922411 0.7373145895607124 23.90901062422249 -13.999999999999998 0.22611093914593172 2.3572340069578104 0.7152054180025195 0.9995047342750705 0.0025571306601198814 13.173206580666019 0.15059120259687167 8.009532476842036 0.023309444008374425 1.0000000000000041e-14 13.999999999999998 -1.642028588955291 LSRLEEQLKEK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSRLEEQLKEK 11 2 Q15075 Q15075 EEA1 Early endosome antigen 1 1 15541400.0 2726900.0 5496700.0 7317800.0 True False 3735108.62170163 5253837.618843836 5589486.354821795 1.0 1.4066090577173918 1.496472237071208 21.832718768352507 -12.0996634766027 0.24547932572762776 2.1095905275009964e-11 1.5376653528624453 0.9993847261389831 0.005357732276791446 5.4565125187933186 0.14487034922098616 2.7969684461879396 0.042457576420959015 7.949439773592563e-13 12.0996634766027 1.5376653528413493 LSRLEEQLKEK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSRLEEQLKEK 11 2 Q15075 Q15075 EEA1 Early endosome antigen 1 1 25537900.0 6598200.0 12042000.0 6897700.0 True False 5486695.649821769 11977127.355850158 8339977.17863863 1.0 2.1829399916212275 1.5200364137036737 22.38750612022386 -10.083899542360474 5.30189885096493 0.9999881666793915 1.8514882026633386 0.6874864451029516 0.2706292524303276 3.785439893221348e-05 6.5406813032321035e-06 0.26203928436002255 0.08734521563781991 8.243287703152219e-11 10.083899542360474 0.8515000359839471 LSRLEEQLKEK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSRLEEQLKEK 11 2 Q15075 Q15075 EEA1 Early endosome antigen 1 1 40065000.0 10383000.0 14301000.0 15381000.0 True False 13440998.179528331 13505136.778410649 12581815.822387338 1.0 1.0047718627757873 0.9360774887649643 23.68013694631494 -6.890245062629452 1.0209498440802678 1.0036693861989616 0.9301410860388345 0.9810539934615127 0.004310849248152086 0.11894383222826001 0.22069692102038244 0.003216251281095402 0.008025136062645781 1.287522826439408e-07 6.890245062629452 -0.07352830016012712 LSSAGLIYLHFGHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSSAGLIYLHFGHK 14 0 Q9HB07;F8VQQ3 Q9HB07 C12orf10 UPF0160 protein MYG1, mitochondrial 0 446220000.0 108590000.0 171780000.0 165850000.0 False True 164738968.99238583 141124516.87673417 133069674.80536282 1.0 0.8566553362565774 0.807760760063475 27.295606623951123 -13.999999999999998 0.15013460954587196 1.6932751119052865 0.7540501846850652 0.9995657864309744 0.0016998894357871269 11.958276746560701 0.12203717701934187 2.418442017476974 0.04841812273847764 1.0000000000000041e-14 13.999999999999998 -0.9392249272202212 LSSAGLIYLHFGHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSSAGLIYLHFGHK 14 0 Q9HB07;F8VQQ3 Q9HB07 C12orf10 UPF0160 protein MYG1, mitochondrial 0 378265000.0 108590000.0 171330000.0 98345000.0 False True 140571895.6289108 161795334.88882598 80447219.10491401 1.0 1.1509792491946038 0.5722852263249183 27.066732946043572 -6.837403108930578 1.2944392564284986 1.0803622250933265 0.5542133220939219 0.9198942681913553 0.06936768001740187 0.171850052983546 0.5604655760387629 0.04203859753256461 0.0967898426276719 1.454108760988091e-07 6.837403108930578 -0.5261489029994045 LSSDQNDK(ub)AASAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSSDQNDKAASAAR 14 1 Q03252 Q03252 LMNB2 Lamin-B2 1 49008000.0 17496000.0 19530000.0 11982000.0 True False 22937425.431505002 16616200.12734375 10742217.5794599 1.0 0.7244143496820299 0.4683270845517498 24.451200132041052 -6.97200750488853 0.20463372065280955 1.1436060636141738 0.04202894938331997 0.9999940960153068 0.0005274883110920483 0.07565652457909978 0.006645480331592338 0.008005743362382856 0.0268764351299765 1.0665776899211646e-07 6.97200750488853 -1.101577114230854 down LSSDQNDK(ub)AASAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSSDQNDKAASAAR 14 1 Q03252 Q03252 LMNB2 Lamin-B2 1 64720000.0 24094000.0 23463000.0 17163000.0 True False 23329149.158388816 32831898.2579286 12667495.421036655 1.0 1.4073337195035567 0.5429900308422355 24.4756303557018 -6.778529051543454 1.541441862375755 1.2310751397706994 0.5364327535626509 0.7622430950201539 0.17215370174039904 0.25284415876401223 1.1865076742813419 0.08797133235994767 0.20784594244112517 1.6652174315856995e-07 6.778529051543454 -0.6946423862080485 LSSDQNDK(ub)AASAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSSDQNDKAASAAR 14 1 Q03252 Q03252 LMNB2 Lamin-B2 1 98436000.0 27015000.0 25171000.0 46250000.0 True False 40983730.061048895 20679038.38807935 37108667.22790484 1.0 0.5045670161616839 0.9054487518004876 25.28854795885068 -9.959145942573533 6.889804659200841 1.000000019885167 0.7050078839810856 0.4192741979043956 0.16365928325273169 5.00272719463228e-08 7.539841752246217e-09 0.15846243142887123 0.052820806540838774 1.0986365858481469e-10 9.959145942573533 -0.29499213590408147 LSSDQNDK(ub)AASAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSSDQNDKAASAAR 14 1 Q03252 Q03252 LMNB2 Lamin-B2 1 51069000.0 17496000.0 17635000.0 15938000.0 True False 23964744.011621892 16855827.388853487 12173772.653413542 1.0 0.7033593757846577 0.5079867595293225 24.514410193563943 -8.409379282438298 0.11852440376306256 1.4929043373916133 2.1313009600509163e-14 0.9999640078745314 0.001213514345175176 0.11603236658025108 0.027229542461279573 0.16541105442510215 0.15452534240863447 3.896015872689829e-09 8.409379282438298 -1.492904337391592 LSSDQNDK(ub)AASAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSSDQNDKAASAAR 14 1 Q03252 Q03252 LMNB2 Lamin-B2 1 62998000.0 24094000.0 32585000.0 6319000.0 True False 20035228.54517987 32409458.13738394 7640273.684245102 1.0 1.6176235805995385 0.3813419780571068 24.256035631136076 -6.770854934731669 1.5710774008589612 1.3538558060283725 0.37414241517064883 0.7338903190946402 0.2603587446905044 0.2650314356295659 1.2911346691569225 0.13061310811759122 0.31068333352594857 1.6949038463733658e-07 6.770854934731669 -0.9797133908577237 LSSDQNDK(ub)AASAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSSDQNDKAASAAR 14 1 Q03252 Q03252 LMNB2 Lamin-B2 1 82022000.0 27015000.0 25486000.0 29521000.0 True False 34971450.0452622 24067681.696005486 24148480.91103941 1.0 0.6882094298307795 0.6905198634824967 25.059674280943128 -10.2674452259311 8.033189196501189 1.0000004050417437 0.6893646466566398 0.9999585098737925 0.000943230588543742 6.842620229166376e-09 6.234255402196614e-10 0.000913280287800193 0.0003044263634219485 5.4020024157870753e-11 10.2674452259311 -0.31063575838510393 LSSDVLTLLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSSDVLTLLIK 11 0 K7EJE8;K7EKE6;P36776-2;P36776;P36776-3 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 8196400.0 1895400.0 3898200.0 2402800.0 False True 2484887.7550797104 3316603.7550645913 2154181.3052851157 1.0 1.3347096858941225 0.8669129222764486 21.244749254573627 -6.714621993500106 1.778629613174451 1.2047918218025861 0.8678502320605349 0.4870695987913872 0.1409473946968367 0.36585917763662534 2.2588640912531703 0.06299503522599083 0.15915242892745413 1.929203346050467e-07 6.714621993500106 -0.33694158974205124 LSSDVLTLLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSSDVLTLLIK 11 0 K7EJE8;K7EKE6;P36776-2;P36776;P36776-3 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 17093100.0 7794300.0 3313700.0 5985100.0 False True 7546874.212884115 4636877.69071721 4417422.760848719 1.0 0.6144103585032696 0.5853314413677706 22.847447797691277 -13.999999999999998 0.3666627926239072 6.25962759424339 0.5821574986898477 0.9997851330159527 0.0027703601251597306 22.435243819082245 0.19625479889624328 92.61380380816682 0.00821303283679195 1.0000000000000041e-14 13.999999999999998 -5.6774700955535415 LSSDVLTLLIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSSDVLTLLIK 11 0 K7EJE8;K7EKE6;P36776-2;P36776;P36776-3 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 24599000.0 4064800.0 13541000.0 6993200.0 False True 6166598.7766852295 11124502.753684103 5610990.954771557 1.0 1.8039932800142264 0.9099004423614646 22.556043551246233 -6.669784971597593 1.9384277797426166 1.513297429181834 0.9135446383579033 0.27792697294136315 0.34153901964171113 0.4616382391725202 3.3440444796204125 0.14186579207400746 0.3790957028957638 2.1390209019432197e-07 6.669784971597593 -0.5997527908239306 LSSDVLTLLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSSDVLTLLIK 11 0 K7EJE8;K7EKE6;P36776-2;P36776;P36776-3 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 26367600.0 1895400.0 5173200.0 19299000.0 False True 2596180.6012590406 4944630.918515274 14740973.675381364 1.0 1.9045789480582869 5.677946159921463 21.307959316096518 -6.943911526306168 0.6221094997623622 0.95875523508291 6.824401105610996 0.9986326611231586 0.0749141338387027 0.08602660210052973 0.04681761476234329 0.07529969268031768 0.3195971982156569 1.1378590648240835e-07 6.943911526306168 5.865645870528086 LSSDVLTLLIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSSDVLTLLIK 11 0 K7EJE8;K7EKE6;P36776-2;P36776;P36776-3 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 15426500.0 7794300.0 2438000.0 5194200.0 False True 6481305.796036166 2424866.0100948876 6280283.204732697 1.0 0.3741323255535769 0.9689842452077466 22.627853073125554 -10.83997942302212 10.411671716839622 1.0070855994058212 0.6715582853806629 0.2890044383954413 0.24284727927796199 0.0396602598901446 0.0006095509091785331 0.2334758658313855 0.0783786223596107 1.4455082576552715e-11 10.83997942302212 -0.33552731402515834 LSSDVLTLLIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSSDVLTLLIK 11 0 K7EJE8;K7EKE6;P36776-2;P36776;P36776-3 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 14480700.0 4064800.0 5321300.0 5094600.0 False True 5261963.729186812 5025164.977201357 4167435.0750103784 1.0 0.9549980265595539 0.7919923605506146 22.327169873338683 -6.947156398398564 0.589239072979088 1.0018884052052992 0.736910520787407 0.9989587870373579 0.002883373769272445 0.08464816175039883 0.04084630035409797 0.002991647900336439 0.013652705735580629 1.1293891251173388e-07 6.947156398398564 -0.26497788441789216 LSSEK(ub)GMGCS ddPTM_RPMI8226_Bortezomib_1h_R1 2 LSSEKGMGCS 10 1 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 152058900.0 36846100.0 57939400.0 57273400.0 True False 48305593.91814003 49295067.366012335 51347297.97324641 1.0 1.0204836203763292 1.0629679465334996 25.52568693092599 -6.959328540596562 0.4448118897744538 0.9985549417364429 1.086566284302719 0.9997443857271434 0.00041923397458121085 0.07994206429780407 0.022025710850380638 0.0005636558679950038 0.003517044572978615 1.09817476395051e-07 6.959328540596562 0.08801134256627619 LSSEK(ub)GMGCS ddPTM_RPMI8226_Bortezomib_2h_R1 2 LSSEKGMGCS 10 1 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 82621320.0 32004310.0 31092600.0 19524410.0 True False 30988350.69732358 43508037.32576695 14410381.301255167 1.0 1.4040126804659108 0.46502575893785053 24.885222636169807 -6.789802441461366 1.4973675183342858 1.2258598530932923 0.4551273829656278 0.8006119720225701 0.17172633790140004 0.23564521640138297 1.0438019449979596 0.0902766235618853 0.21136783409566204 1.622548019050246e-07 6.789802441461366 -0.7707324701276644 down LSSEK(ub)GMGCS ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSSEKGMGCS 10 1 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 233594000.0 38543000.0 45721000.0 149330000.0 True False 58472548.87073878 37561730.330196515 119814860.04633579 1.0 0.642382298285502 2.0490787961236685 25.801256145267274 -6.839307408351022 1.2856952195634896 0.8097414758633337 2.0946901283118504 0.9232437528914068 0.16538729285504083 0.16960888021351933 0.5449263637022408 0.10088191501382364 0.2323597371297691 1.4477467265855798e-07 6.839307408351022 1.2849486524485167 up LSSEK(ub)GMGCS ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LSSEKGMGCS 10 1 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 123375940.0 36846100.0 43210090.0 43319750.0 True False 50469098.89841238 41300925.34714058 33088517.248256493 1.0 0.8183408511072069 0.6556193387732027 25.58889699244888 -6.9724294783517395 0.1914615690772044 1.1081994239739328 0.3613086835388592 0.9999956498695943 0.0002933248980724266 0.07552201686313843 0.006118568344825164 0.005673780478122826 0.01766722885007195 1.065541874543232e-07 6.9724294783517395 -0.7468907404350735 LSSEK(ub)GMGCS ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LSSEKGMGCS 10 1 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 91527770.0 32004310.0 22227060.0 37296400.0 True False 26613001.796330422 22107318.41605401 45094904.800930366 1.0 0.8306961606676897 1.6944689346223376 24.665627911604084 -6.855839215384103 1.2066505365576057 0.9089805766793787 1.7330770616341422 0.948367603269236 0.08492135305920899 0.1511537665303996 0.4205988561487573 0.05497743211333151 0.127785206086027 1.3936726733056953e-07 6.855839215384103 0.8240964849547635 LSSEK(ub)GMGCS ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSSEKGMGCS 10 1 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 160692000.0 38543000.0 37392000.0 84757000.0 True False 49894673.29611482 35311102.32979037 69332095.68026035 1.0 0.7077128678692033 1.3895690882429141 25.572382467359724 -6.790220346321353 1.4953409012654226 0.836681670691107 1.3968738520502566 0.8020330251198741 0.1242744784834007 0.2350460383781446 1.038266624449212 0.06541249373570716 0.15312948229772522 1.6209874545141637e-07 6.790220346321353 0.5601921813591496 LSSEMNTSTVNSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSSEMNTSTVNSAR 14 0 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 0 11630060.0 670860.0 6798700.0 4160500.0 False True 879503.9566174819 5784360.461125037 3730011.370334076 1.0 6.576844160396198 4.241039897852729 19.746330542389398 -9.455890192392692 9.433160124299555 1.0000000000009452 5.408942029039361 0.8261005227312482 0.9535880970416089 0.0 0.0 0.9233077047459283 0.30776923491530933 3.5003365882692564e-10 9.455890192392692 4.408942029038416 LSSEMNTSTVNSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSSEMNTSTVNSAR 14 0 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 0 9876500.0 2901600.0 1032500.0 5942400.0 False True 2809490.296255537 1444782.6344163697 4385907.171821258 1.0 0.5142508007028759 1.5611042250855094 21.421876986686907 -6.780536770914504 1.5338367922060292 0.7251503473037875 1.5695287975487808 0.7692723252483956 0.2054635657560687 0.24973804155822932 1.1605633675405918 0.10550275298473655 0.24882473064031618 1.6575369903010954e-07 6.780536770914504 0.8443784502449934 LSSEMNTSTVNSAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSSEMNTSTVNSAR 14 0 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 0 10988860.0 670860.0 5004100.0 5313900.0 False True 918895.071309824 4783002.315654194 4058866.2632058123 1.0 5.205167015246193 4.417116153882692 19.80954060391229 -10.22140199816609 4.8854615358516424 0.9994012514243859 4.81114158457077 0.9689292553136309 0.32172041697207504 0.002098351043545928 0.0003344141554310176 0.31153889442755206 0.10383481808586462 6.006175275034317e-11 10.22140199816609 3.8117403331463837 LSSETYSQAK(ub)DLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSSETYSQAKDLAK 14 1 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 1 6607500.0 1355700.0 2886400.0 2365400.0 True False 1127324.6176932165 2870850.390294458 2859994.203626104 1.0 2.546604895552555 2.5369748506675527 20.104471574543066 -10.059451245854339 4.717059549677372 0.9999438581343983 2.5417898731461586 0.9999707412501736 0.0039314494860271075 1373594.3185629987 852068.6381019624 913.8819304268087 0.0014387631563474884 8.72064794282239e-11 10.059451245854339 1.5418460150117603 LSSFVTK(ub)GYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSSFVTKGYR 10 1 F8VPD4;P27708;H7C3Z5 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 37166900.0 10638000.0 8150900.0 18378000.0 True False 16138623.741974398 6696308.211727626 14745580.244636448 1.0 0.41492436522399523 0.9136826336861159 23.94401421895573 -10.238462399142753 7.978782412419796 1.0000002817111255 0.6643034994550614 0.3765668246604128 0.20361721045437722 1.0204906509361086e-06 9.720492378138758e-08 0.19715168078356696 0.06571717209091782 5.774808683658898e-11 10.238462399142753 -0.33569678225606414 LSSGNEENK(ub)KEEDNDEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSSGNEENKKEEDNDEIK 18 2 Q9UHD1;Q9UHD1-2;E9PPQ5 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 1 46590070.0 16199370.0 23349900.0 7040800.0 True False 21237530.944922246 19866185.93719733 6312285.556122615 1.0 0.9354282279196493 0.29722313636613396 24.34011271375421 -6.926388510842459 0.7758719140479802 1.0111145217819304 0.177493749488435 0.9957793868334214 0.0206053355037776 0.09455716480540696 0.0871909129366787 0.018383705331164048 0.058934962810379736 1.1847084583482799e-07 6.926388510842459 -0.8336207722934954 down LSSGNEENK(ub)KEEDNDEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSSGNEENKKEEDNDEIK 18 2 Q9UHD1;Q9UHD1-2;E9PPQ5 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 1 58214700.0 28961500.0 20045100.0 9208100.0 True False 28042133.03522363 28049212.963815585 6796222.372921263 1.0 1.000252474680976 0.24235753979144706 24.741092756865974 -6.906818714930019 0.9171297272290467 1.0258916237135556 0.1507964412663289 0.989664553998846 0.036315750865043274 0.10655944321476135 0.15045803627115148 0.029272215323600533 0.07912945706452934 1.2393137982688627e-07 6.906818714930019 -0.8750951824472266 down LSSGNEENK(ub)KEEDNDEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSSGNEENKKEEDNDEIK 18 2 Q9UHD1;Q9UHD1-2;E9PPQ5 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 1 57872210.0 41551000.0 11861410.0 4459800.0 True False 63035904.78499509 9744648.711880682 3578318.575200222 1.0 0.15458886082650905 0.05676635541926887 25.909670475365434 -13.999999999999998 0.3043641885406237 8.908248538798187 0.03376815864486364 0.9996595444069942 0.007813719124046103 16.878313868539813 0.1753430578110732 84.26719949385685 0.03470192321383943 1.0000000000000041e-14 13.999999999999998 -8.874480380153324 LSSGNEENK(ub)KEEDNDEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSSGNEENKKEEDNDEIK 18 2 Q9UHD1;Q9UHD1-2;E9PPQ5 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 1 46372370.0 16199370.0 22302500.0 7870500.0 True False 22188714.860513706 21317101.805495042 6011649.9980355995 1.0 0.9607181821706242 0.27093277081737305 24.4033227752771 -6.9186184941613975 0.8349235841105329 1.0159911655142482 0.1631634469436117 0.9937880774286995 0.026388384259875896 0.09899168813377829 0.10988189527027394 0.0225714135034207 0.06674298516041297 1.206094968863622e-07 6.9186184941613975 -0.8528277185706364 down LSSGNEENK(ub)KEEDNDEIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSSGNEENKKEEDNDEIK 18 2 Q9UHD1;Q9UHD1-2;E9PPQ5 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 1 62356800.0 28961500.0 29367400.0 4027900.0 True False 24082770.461991668 29209191.98722752 4870115.267094608 1.0 1.2128667685192849 0.20222404539298364 24.52149803230025 -6.8516788325826505 1.2268278062601914 1.113785816771252 0.160464799751014 0.9427291376686292 0.10410533954187566 0.15562080037233994 0.4498646331751652 0.06636782529027409 0.15376561224208224 1.4070877023636013e-07 6.8516788325826505 -0.953321017020238 down LSSGNEENK(ub)KEEDNDEIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSSGNEENKKEEDNDEIK 18 2 Q9UHD1;Q9UHD1-2;E9PPQ5 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 1 47952270.0 41551000.0 5580980.0 820290.0 True False 53788588.59265924 5270393.556924296 671005.6368861652 1.0 0.09798348859526626 0.01247486975290778 25.680796797457884 -13.822422899413304 0.33810431017304343 9.999546745698341 4.2041331524403486e-35 0.9997115829861557 0.007586833049174799 17.58390771181973 0.18917947214808536 112.39324773559282 0.02649707495997318 1.505140703709966e-14 13.822422899413304 -9.999546745698341 LSSGNEENKK(ub)EEDNDEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSSGNEENKKEEDNDEIK 18 2 Q9UHD1;Q9UHD1-2;E9PPQ5 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 1 6842100.0 2938500.0 2566500.0 1337100.0 True False 2845218.925953579 3591316.8341206945 986873.3978598209 1.0 1.2622286465766637 0.34685323820172076 21.440108234592735 -6.830109736844089 1.327387198394081 1.14010145573078 0.32215598125131933 0.9061197943775808 0.11793043613023402 0.1806589236819261 0.6224947293343007 0.06975668943846679 0.16053207176467185 1.478734696609562e-07 6.830109736844089 -0.8179454744794608 down LSSGNEENKK(ub)EEDNDEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSSGNEENKKEEDNDEIK 18 2 Q9UHD1;Q9UHD1-2;E9PPQ5 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 1 5078510.0 1613100.0 2496300.0 969110.0 True False 2209506.662388389 2386005.211839804 740226.1774469571 1.0 1.0798814289433403 0.33501875782841134 21.07529285062511 -6.880364391680562 1.077814063906195 1.0497454325744555 0.2818709332358221 0.9739760599428926 0.05386450082237082 0.12730552684494162 0.2703666368175644 0.0384860397774307 0.09315199281281031 1.3171511285551976e-07 6.880364391680562 -0.7678744993386335 down LSSK(ub)CSVVLGPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSSKCSVVLGPK 12 1 Q9UM07 Q9UM07 PADI4 Protein-arginine deiminase type-4 1 5142900.0 1341500.0 2675600.0 1125800.0 True False 1758719.491104478 2276410.9094071165 1009313.0154361492 1.0 1.2943570142487746 0.5738908453230932 20.74609396625348 -6.795751148807663 1.4730207811867668 1.163291843563515 0.5649368595579097 0.8195177060725727 0.12564999218365075 0.2268672718964431 0.9721837022836669 0.06711834011035403 0.15652590751603765 1.6004748396797253e-07 6.795751148807663 -0.5983549840056052 LSSK(ub)CSVVLGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSSKCSVVLGPK 12 1 Q9UM07 Q9UM07 PADI4 Protein-arginine deiminase type-4 1 5310600.0 1341500.0 2080000.0 1889100.0 True False 1837488.8026743687 1988098.7223598103 1442933.4872357587 1.0 1.0819650816191297 0.7852747103196736 20.80930402777637 -6.83301806993427 1.3142511343997878 1.0437152404021894 0.7767808169323877 0.9117923051213974 0.03715446574960218 0.17712077359680364 0.5972310367525298 0.022188715272511608 0.05106634460685634 1.468865160475229e-07 6.83301806993427 -0.2669344234698018 LSSK(ub)CSVVLGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSSKCSVVLGPK 12 1 Q9UM07 Q9UM07 PADI4 Protein-arginine deiminase type-4 1 6520000.0 1232000.0 1158400.0 4129600.0 True False 1024462.5868540538 1152159.4692756035 4993080.266886935 1.0 1.1246476777777552 4.873853209437169 19.966435867733168 -6.913967151913922 0.868267693826288 0.8979707396360809 5.401881974197389 0.9923349226172099 0.15737124851276288 0.10185282059296703 0.12496412733385133 0.1314248313618433 0.3735910892135583 1.2190818013157773e-07 6.913967151913922 4.503911234561308 up LSSK(ub)CSVVLGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSSKCSVVLGPK 12 1 Q9UM07 Q9UM07 PADI4 Protein-arginine deiminase type-4 1 74505600.0 3542800.0 4842800.0 66120000.0 True False 4586224.439028504 4573293.922836669 54086838.44849172 1.0 0.997180574923068 11.793325679444699 22.12887552806982 -6.9068323418061714 0.9170121757538903 0.6313277587071713 13.098099289786752 0.9896708714809049 0.5171750865844127 0.1065508410801688 0.15039607551538867 0.4168954621491656 1.1270965329303475 1.2392749128779528e-07 6.9068323418061714 12.466771531079582 up LSSLIIGPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSSLIIGPSK 10 0 Q92615;H0Y641;H0Y4V9 Q92615 LARP4B La-related protein 4B 0 5343100.0 1413800.0 1380100.0 2549200.0 False True 1853505.4912586764 1174194.4595876664 2285433.2376530785 1.0 0.6334993152840868 1.2330328927707084 20.82182495866518 -6.741258365273975 1.6819549455272567 0.7822532689805297 1.2334909722944716 0.6106296042035374 0.15398459333452805 0.31554733038371596 1.7532235340888178 0.07240976321489133 0.1774514210883792 1.814435919135587e-07 6.741258365273975 0.45123770331394186 LSSLIIGPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSSLIIGPSK 10 0 Q92615;H0Y641;H0Y4V9 Q92615 LARP4B La-related protein 4B 0 2951030.0 862940.0 506790.0 1581300.0 False True 835546.4420494738 709153.889874936 1167110.0920168562 1.0 0.8487306679632131 1.3968225262908247 19.672360494048657 -6.833116209419023 1.3140418493244121 0.9193319173775428 1.4125204124731847 0.9119440342038297 0.06858357784455796 0.17699771775432985 0.5966258456068403 0.040967108520112656 0.09427272180984322 1.468533271884133e-07 6.833116209419023 0.4931884950956419 LSSLIIGPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSSLIIGPSK 10 0 Q92615;H0Y641;H0Y4V9 Q92615 LARP4B La-related protein 4B 0 2491700.0 1413800.0 1077900.0 0.0 False True 1936520.0665084054 1030274.8138613659 0.0 1.0 0.5320238254587144 0.0 20.88503502018807 -7.833149500253963 0.6132986009847166 1.0059561436107256 8.686369343894536e-18 0.9882853902726171 0.04421656496303395 0.11558909936711685 0.1572568651922265 0.04368138146681028 0.07771682988015244 1.4684207058095855e-08 7.833149500253963 -1.0059561436107256 down LSSLIILMPHHVEPLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSSLIILMPHHVEPLER 17 0 P50454;E9PPV6;E9PR70;E9PKH2 P50454 SERPINH1 Serpin H1 0 10481500.0 2225600.0 5760200.0 2495700.0 False True 2917783.1527410597 4900800.613083738 2237468.904444836 1.0 1.6796315409799278 0.7668386536343132 21.476441236647837 -6.707323429678852 1.804524078406643 1.4189500337037222 0.7691255298553723 0.45250753735766214 0.2865146783835662 0.3804679050848717 2.4133109177168053 0.1264269458460432 0.32225734934029865 1.9618986589347915e-07 6.707323429678852 -0.6498245038483499 LSSLIILMPHHVEPLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSSLIILMPHHVEPLER 17 0 P50454;E9PPV6;E9PR70;E9PKH2 P50454 SERPINH1 Serpin H1 0 10084300.0 3489100.0 4006900.0 2588300.0 False True 3378340.430336779 5606876.065707461 1910346.5826644043 1.0 1.6596539577121672 0.5654689401665676 21.687883283020675 -6.743467100190395 1.6739147124318554 1.3909103538638399 0.5643215400501661 0.6204155294959237 0.2771481319781191 0.3115921486038648 1.7155441780435663 0.13091029443634622 0.3200385976946943 1.805231486561118e-07 6.743467100190395 -0.8265888138136738 LSSLIILMPHHVEPLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSSLIILMPHHVEPLER 17 0 P50454;E9PPV6;E9PR70;E9PKH2 P50454 SERPINH1 Serpin H1 0 41070900.0 6987900.0 12345000.0 21738000.0 False True 10601155.18392019 10141938.298074756 17441474.77189614 1.0 0.9566823730170488 1.6452428503594902 23.33771814478379 -6.891910044714038 1.0110501227495428 0.964678677746187 1.7067220960686722 0.9820916143716351 0.04213759806190423 0.11760598433860148 0.2129220345046887 0.03167444128720965 0.07952499720710214 1.2825962189151685e-07 6.891910044714038 0.7420434183224852 LSSLIILMPHHVEPLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSSLIILMPHHVEPLER 17 0 P50454;E9PPV6;E9PR70;E9PKH2 P50454 SERPINH1 Serpin H1 0 16949000.0 2225600.0 6171700.0 8551700.0 False True 3048464.464578517 5899013.886917335 6531964.587789985 1.0 1.935077136525827 2.142706488360887 21.539651298170728 -10.732364507250754 0.3004518820233849 6.963883449990073e-13 2.206300636110503 0.9991627107375715 0.014381736797611844 2.4243139358915258 0.1497162449920988 1.8320171776523597 0.07442241175615674 1.851976590380029e-11 10.732364507250754 2.2063006361098068 LSSLIILMPHHVEPLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSSLIILMPHHVEPLER 17 0 P50454;E9PPV6;E9PR70;E9PKH2 P50454 SERPINH1 Serpin H1 0 7153200.0 3489100.0 1764600.0 1899500.0 False True 2901341.2433380526 1755093.7495543251 2296676.6677043135 1.0 0.6049249648190482 0.7915913624355128 21.46828855845495 -10.113605026611518 4.850098659093276 1.000013652938036 0.6982581636277758 0.776984576878914 0.07620623772580644 19863674.141511995 41420467.89099085 2080.5777020333426 0.026087425335622853 7.698302517079947e-11 10.113605026611518 -0.3017554893102601 LSSLIILMPHHVEPLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSSLIILMPHHVEPLER 17 0 P50454;E9PPV6;E9PR70;E9PKH2 P50454 SERPINH1 Serpin H1 0 34990900.0 6987900.0 12986000.0 15017000.0 False True 9045974.302102093 12263317.684388578 12284060.087431962 1.0 1.3556657663220248 1.3579587645498181 23.10884446687624 LSSLPFQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSSLPFQK 8 0 P61970;H3BRV9 P61970 NUTF2 Nuclear transport factor 2 0 15889960.0 764160.0 10338000.0 4787800.0 False True 1001821.1601359654 8795610.697208378 4292404.383820572 1.0 8.779621600340976 4.284601438482308 19.934193558483038 -9.907750547901754 8.492081882338452 0.9999999912088234 6.532111519411642 0.6688261974336405 1.835084296679398 9.62031290527693e-08 2.494236210271892e-08 1.7768127167432242 0.5922709099938381 1.23665754663862e-10 9.907750547901754 5.532111528202819 LSSLPFQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSSLPFQK 8 0 P61970;H3BRV9 P61970 NUTF2 Nuclear transport factor 2 0 10551600.0 3446400.0 1851600.0 5253600.0 False True 3336995.918463983 2590953.53596644 3877524.5553783276 1.0 0.776432935272829 1.1619806107413968 21.670118491260837 -6.749493215525084 1.651653180280018 0.8684587002488215 1.1627196914100277 0.6467839560693649 0.09394242805002428 0.3009458196923228 1.615086557914584 0.04493331267547049 0.10914691033738538 1.7803557210523363e-07 6.749493215525084 0.2942609911612062 LSSLPFQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSSLPFQK 8 0 P61970;H3BRV9 P61970 NUTF2 Nuclear transport factor 2 0 17748960.0 764160.0 7104100.0 9880700.0 False True 1046690.6026475179 6790217.371882848 7547082.1594041465 1.0 6.487320469590108 7.210423156866434 19.99740362000593 -9.617011317284538 0.5656995504364213 1.9336342224071348e-22 7.15546124749806 0.998873675949239 0.09306205337200302 0.9154747905947677 0.2549562256272078 2.050528994313061 0.13095698591438412 2.415397890745411e-10 9.617011317284538 7.15546124749806 LSSLPFQK(ub)IQHSITAQDHQPTPDSCIISMVVGQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSSLPFQKIQHSITAQDHQPTPDSCIISMVVGQLK 35 1 P61970;H3BRV9 P61970 NUTF2 Nuclear transport factor 2 1 46565700.0 7592700.0 17291000.0 21682000.0 True False 11518681.000722792 14205285.954800367 17396543.196441825 1.0 1.2332389406312225 1.5102895197245414 23.45747218805227 -6.968844530850541 0.28443528116879374 0.942133611322677 1.8098887181424903 0.9999719130336152 0.0011054024366464444 0.07667946963454862 0.010365936047819624 0.004990205006323713 0.02529048791833615 1.0743739489113066e-07 6.968844530850541 0.8677551068198133 LSSMK(ub)FK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSSMKFK 7 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 11222130.0 759630.0 2432800.0 8029700.0 True False 1152414.246391804 1998647.8324468415 6442626.275457464 1.0 1.734313714625262 5.590547232151334 20.13622796995001 -6.938716581547661 0.6713961656651061 0.9556048048987251 6.592333250130045 0.9979909358920762 0.09024438386150521 0.08835702364092551 0.057312528755439116 0.08701441808661216 0.3338187350848616 1.1515516407482546e-07 6.938716581547661 5.63672844523132 LSSMK(ub)FK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSSMKFK 7 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 3376260.0 673990.0 881570.0 1820700.0 True False 923182.3168948928 842619.3224378547 1390688.1584935405 1.0 0.9127333864799205 1.5064068419021448 19.816256064567984 -6.869543028200875 1.1365875298306247 0.9507844382600387 1.5408631698826687 0.9642210034706442 0.049506636315703755 0.13728971087908332 0.331773601189214 0.03381468630635971 0.07999027895950374 1.350383030551139e-07 6.869543028200875 0.59007873162263 LSSMK(ub)FKDPLKDGEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSSMKFKDPLKDGEAK 16 3 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 45601600.0 3087600.0 6017000.0 36497000.0 True False 4684114.9337958405 4943219.338964431 29283351.952796664 1.0 1.0553155524214735 6.251629681739358 22.15934504490348 -6.909227699722222 0.9009840934619265 0.835155893304282 6.9121762784070215 0.9906267065045067 0.23842892631799276 0.10493077010208499 0.14155613192762653 0.1944626201671602 0.5339713449665837 1.2324584883017153e-07 6.909227699722222 6.07702038510274 up LSSMK(ub)FKDPLKDGEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSSMKFKDPLKDGEAK 16 3 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 37186800.0 3087600.0 6205200.0 27894000.0 True False 3996959.065695045 5859875.165190819 22817578.216609646 1.0 1.4660833570913303 5.70873452581677 21.930471366995928 -6.927776073376329 0.7648247994271359 0.9298788068443052 6.532375487721045 0.9960828087649279 0.13258683053516154 0.09380934004958165 0.0834584047297658 0.1192316047331738 0.38868769645639284 1.1809293778226291e-07 6.927776073376329 5.602496680876739 up LSSMLGVPAQETAPAK(ub)LIVYLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSSMLGVPAQETAPAKLIVYLQR 23 1 Q9BU02 Q9BU02 THTPA Thiamine-triphosphatase 1 20304000.0 8890800.0 4558200.0 6855000.0 True False 8608566.420577878 6378313.0306989765 5059469.854408106 1.0 0.7409262726314437 0.587725017990681 23.03734157580541 -11.599219463308128 0.0733847236968796 2.1062898555786416 5.3037791665568205e-09 0.9999539345719965 0.0011548222620108093 4.718785225329116 0.05141548365229513 1.256497936284952 0.4103717830855013 2.5164049840751545e-12 11.599219463308128 -2.1062898502748624 LSSMLGVPAQETAPAK(ub)LIVYLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LSSMLGVPAQETAPAKLIVYLQR 23 1 Q9BU02 Q9BU02 THTPA Thiamine-triphosphatase 1 26020900.0 11770100.0 10093400.0 4157400.0 True False 9787359.653840017 10039024.850816967 5026693.118354262 1.0 1.0257132879425976 0.5135903140518665 23.222488284304024 -6.89508330433849 0.9918503438498301 1.0242585253578762 0.46489774379513993 0.9839566451595224 0.02984043582377528 0.11511464465635735 0.19854171128020803 0.022757131556426266 0.05787542575686123 1.2732588270320597e-07 6.89508330433849 -0.5593607815627363 LSSPEDDPTCK(ub)TK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSSPEDDPTCKTK 13 1 H3BNM2;Q6V1X1-6;Q6V1X1-4;Q6V1X1-2;Q6V1X1-5;Q6V1X1-3;Q6V1X1;H0YK36;J3KPT0 H3BNM2 DPP8 Dipeptidyl peptidase 8 1 10513000.0 1920200.0 3319700.0 5273100.0 True False 2913083.785423876 2727273.598065516 4230869.4737181645 1.0 0.9362152958702755 1.4523679321851504 21.47411576585125 -6.875960309056574 1.102128918338932 0.9622365481792219 1.4862211831032386 0.9702760392835825 0.03961258444460955 0.13126627569909916 0.2944494750970735 0.027780973287612424 0.066541335840984 1.3305760161249038e-07 6.875960309056574 0.5239846349240167 LSSPEDDPTCK(ub)TK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSSPEDDPTCKTK 13 1 H3BNM2;Q6V1X1-6;Q6V1X1-4;Q6V1X1-2;Q6V1X1-5;Q6V1X1-3;Q6V1X1;H0YK36;J3KPT0 H3BNM2 DPP8 Dipeptidyl peptidase 8 1 9345300.0 1920200.0 3024000.0 4401100.0 True False 2485736.752800755 2855711.741690363 3600144.9590994734 1.0 1.148839167491387 1.4483210883224382 21.245242087943698 -6.959926597011633 0.4364683987726508 0.9888888507676525 1.6198795435739524 0.9997674629411545 0.002843027963906978 0.07972736223768354 0.021228399907258798 0.003931870094734521 0.024831196894497712 1.0966635348514711e-07 6.959926597011633 0.6309906928062998 LSSSIIHEIDSILGNKPYSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSSSIIHEIDSILGNKPYSK 20 1 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28 Q13303-3 KCNAB2 Voltage-gated potassium channel subunit beta-2 0 29275600.0 7684900.0 7790600.0 13800100.0 False True 7440947.05600159 10901427.207442291 10185439.815874156 1.0 1.4650591014015626 1.3688364853582664 22.827054823190227 -10.035408202047014 4.668068954095706 0.9999892538511383 1.416947793389942 0.9615901814631708 0.039282718580812705 4832988.887880664 10389952.83291874 378.237621787141 0.013447520423719807 9.217046912615587e-11 10.035408202047014 0.4169585395388036 LSSSIIHEIDSILGNKPYSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSSSIIHEIDSILGNKPYSK 20 1 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28 Q13303-3 KCNAB2 Voltage-gated potassium channel subunit beta-2 0 13920900.0 2553100.0 5714600.0 5653200.0 False True 3873239.3566116607 4694784.981626407 4535842.542114417 1.0 1.212108147567064 1.1710720986999386 21.885109228430302 -10.136717300191108 4.491522386367011 0.9999745950834711 1.1915901231393236 0.9667375120437907 0.016752896817176222 4.262479607755622e-06 8.19225278893438e-07 0.01622307222381913 0.005406974195027739 7.29932498170722e-11 10.136717300191108 0.19161552805585247 LSSSIIHEIDSILGNKPYSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSSSIIHEIDSILGNKPYSK 20 1 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28 Q13303-3 KCNAB2 Voltage-gated potassium channel subunit beta-2 0 3765930.0 1256600.0 634030.0 1875300.0 False True 1721198.9783381384 606016.4581431687 1432392.7630158388 1.0 0.3520897152334433 0.8322063753482184 20.714982458374593 -9.894141215346817 6.438186851624181 1.0000000309582966 0.5921480452909315 0.49035928097105574 0.19600680571518284 8.717635417488687e-08 1.4495304101831382e-08 0.189782787709385 0.06326092452316902 1.2760238289894964e-10 9.894141215346817 -0.40785198566736514 LSSSIIHEIDSILGNKPYSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSSSIIHEIDSILGNKPYSK 20 1 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28 Q13303-3 KCNAB2 Voltage-gated potassium channel subunit beta-2 0 20506400.0 7684900.0 5953700.0 6867800.0 False True 6390334.848794424 5921626.236383077 8303825.2268805895 1.0 0.926653512921976 1.2994350723964265 22.607460098624504 -6.855613478742468 1.2076410941855644 0.9605807869512041 1.3160367225745409 0.9480880305755848 0.03673897762712219 0.15139029691842767 0.4220515763152442 0.023765834450255176 0.05523267643490437 1.394397261754133e-07 6.855613478742468 0.35545593562333677 LSSSIIHEIDSILGNKPYSK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSSSIIHEIDSILGNKPYSKK 21 2 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28 Q13303-3 KCNAB2 Voltage-gated potassium channel subunit beta-2 1 90433200.0 46665900.0 10136000.0 33631300.0 True False 45184516.54812222 14183357.658541733 24822253.612626623 1.0 0.31389862594714796 0.5493530861659333 25.429325150876668 -10.178826931618957 5.3440216818233575 1.0000232416860866 0.431625856056566 0.885968517188474 0.09612388086693782 2.661871546854136e-05 4.0902207112883864e-06 0.09307534461485943 0.031023849147463502 6.624804526628123e-11 10.178826931618957 -0.5683973856295206 LSSSIIHEIDSILGNKPYSK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSSSIIHEIDSILGNKPYSKK 21 2 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28 Q13303-3 KCNAB2 Voltage-gated potassium channel subunit beta-2 1 187634000.0 115530000.0 42854000.0 29250000.0 True False 175267456.37434682 35206368.88016981 23468724.679269545 1.0 0.20087225323207702 0.13390235223784858 27.384982900741388 -13.873538152465361 0.3522535983304612 9.999789985097708 0.12485208014060971 0.9997553601704292 0.006153911525110876 19.059678346493072 0.19091621001958345 127.98885667082914 0.019839177807679992 1.3380176660781146e-14 13.873538152465361 -9.874937904957099 LSSSIIHEIDSILGNKPYSK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSSSIIHEIDSILGNKPYSKK 21 2 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28 Q13303-3 KCNAB2 Voltage-gated potassium channel subunit beta-2 1 95166300.0 46665900.0 36476400.0 12024000.0 True False 38804763.49989663 36279894.39320148 14538162.80730544 1.0 0.9349340421388761 0.37464892183518056 25.209730426310944 -6.92875316990905 0.7569595094796402 1.008926147456321 0.2631952758508484 0.9962874086058034 0.017104361059272235 0.09329050515302378 0.08089073691290811 0.015468835086029725 0.05104818143927584 1.1782754529124782e-07 6.92875316990905 -0.7457308716054725 down LSSSIIHEIDSILGNKPYSK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSSSIIHEIDSILGNKPYSKK 21 2 Q13303-3;A0A590UJB6;Q13303;Q13303-2;Q13303-4;A0A5F9UN28 Q13303-3 KCNAB2 Voltage-gated potassium channel subunit beta-2 1 172396900.0 115530000.0 35575900.0 21291000.0 True False 149555862.43676266 33596069.89127054 17416256.464108247 1.0 0.22463893654102735 0.11645318465180485 27.156109222833837 -13.999999999999998 0.27746623284610716 7.23178915577485 0.08306306619093631 0.9995995851154411 0.007873975589042067 15.262889207319375 0.16682870392654756 53.89236168183543 0.04331677255712202 1.0000000000000041e-14 13.999999999999998 -7.1487260895839135 LSSSPGLFGAFSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSSSPGLFGAFSVR 14 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 0 5826000.0 1644400.0 2537800.0 1643800.0 False True 2155824.3243922545 2159170.132266919 1473715.344443014 1.0 1.001551985399185 0.6835971409026879 21.039808188669536 -6.905799449328 0.9238517062151297 1.0111994794302366 0.6459931557232481 0.9892378664320552 0.015511400953878377 0.1072621299540447 0.15431395303563397 0.012441329495844746 0.03342243900539744 1.2422258163967338e-07 6.905799449328 -0.36520632370698847 LSSSPGLFGAFSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSSSPGLFGAFSVR 14 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5 Q5VT52-2 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 0 6460800.0 1644400.0 1713700.0 3102700.0 False True 2252379.118239089 1637983.0675519272 2369906.162112326 1.0 0.7272235185844305 1.052179068311164 21.103018250192427 -6.684076451499601 1.887346670227037 0.8280446095342722 1.0509851999757926 0.3428467137822463 0.11550798062171239 0.4295624661026741 2.9617432780322774 0.04904534392801642 0.12868487640182003 2.0697769612896992e-07 6.684076451499601 0.22294059044152048 LSSTWEGIQAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSSTWEGIQAGK 12 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 22929500.0 2253200.0 11352000.0 9324300.0 False True 2953967.0200198395 9658325.849749427 8359510.881001316 1.0 3.2696119436311646 2.829926950553826 21.494222288345146 -10.079618389965221 6.5181661401330455 0.9999979464595332 3.0497694470925016 0.9666419869696679 0.17950064676646238 5.356645834034772e-06 7.56509074191936e-07 0.1738009246507532 0.05793358462999397 8.324949544537633e-11 10.079618389965221 2.0497715006329686 LSSTWEGIQAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSSTWEGIQAGK 12 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 35341500.0 2253200.0 8806300.0 24282000.0 False True 3086268.9304404715 8417208.547460184 18547091.703487765 1.0 2.727308843516395 6.009551377896523 21.557432349868037 -6.961033500207505 0.42061578349499534 0.8558771117249578 8.004922518094357 0.999806627824276 0.02889243797940273 0.07933399933211228 0.019782417281501742 0.042475488688700824 0.27317527507912065 1.0938719849285945e-07 6.961033500207505 7.1490454063694 LSSYYK(ub)FK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSSYYKFK 8 1 Q7Z7L7 Q7Z7L7 ZER1 Protein zer-1 homolog 1 5826290.0 961190.0 1949800.0 2915300.0 True False 799272.072936891 1939296.0403950005 3524875.751175777 1.0 2.426327787569432 4.410107484706393 19.608327155890994 -6.966482557646326 0.33162417635790004 0.7628440415398247 6.13869094052388 0.9999405244700387 0.010784182357654824 0.0774614169790822 0.013105299263974484 0.02878136976774135 0.17280505567355137 1.0802330048725809e-07 6.966482557646326 5.375846898984055 LSTADGK(ub)AFADPEVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSTADGKAFADPEVLR 16 1 H0YM23;O75179-6;O75179-7;O75179-2;O75179;O75179-5;O75179-3;O75179-4;Q8IWZ3;Q8IWZ3-4;Q8IWZ3-6;E9PDP5;A0A1W2PQ15;Q8IWZ3-5;Q8IWZ3-2 H0YM23;Q8IWZ3 ANKRD17;ANKHD1 Ankyrin repeat domain-containing protein 17;Ankyrin repeat and KH domain-containing protein 1 1 11294200.0 2147600.0 3767400.0 5379200.0 True False 2079425.613536806 5271742.4667314645 3970226.1474590907 1.0 2.5351916569715534 1.9092898161941474 20.987753646277167 -10.406149794408998 5.637233971018614 0.9994511214929902 2.2222407365827457 0.8356452812401858 0.2555233564955746 0.0017634185598338619 0.00018576576704074053 0.24750783324491302 0.08246980868952976 3.925095298708258e-11 10.406149794408998 1.2227896150897555 LSTENK(ub)ITTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSTENKITTK 10 1 E9PHA2;Q15003;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 1 3958290.0 1208700.0 1955400.0 794190.0 True False 1005087.6044890383 1944865.872083488 960251.4570803308 1.0 1.9350212492892196 0.955390806524272 19.93888982302066 -6.656801413270254 1.9850716272135904 1.6034626220330308 0.9595590130436251 0.22183486445600664 0.39842148575190034 0.49202017678660176 3.723893083056031 0.16238120818418308 0.4413022371714476 2.20393400981144e-07 6.656801413270254 -0.6439036089894057 LSTIALALGVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSTIALALGVER 12 0 P30153;C9J9C1;E9PPI5;E9PNM7;E9PHZ6;P30154;P30154-2;P30154-4;P30154-5 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 0 39107300.0 16399000.0 14197000.0 8511300.0 False True 15878422.721358744 19865936.136376973 6281935.196473193 1.0 1.2511278031195412 0.39562715432831336 23.92056427410489 -6.828111258505739 1.336341790777667 1.1343704802228285 0.37348364065384926 0.9020436995982634 0.11237347441095279 0.18315178630103388 0.640336415764175 0.06603734884340554 0.15198580644053386 1.485555020815905e-07 6.828111258505739 -0.7608868395689792 down LSTIALALGVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSTIALALGVER 12 0 P30153;C9J9C1;E9PPI5;E9PNM7;E9PHZ6;P30154;P30154-2;P30154-4;P30154-5 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 0 211510000.0 53256000.0 82661000.0 75593000.0 False True 80793245.53511836 67909498.7166592 60652010.41641113 1.0 0.8405343573819054 0.7507064484746755 26.267731350254053 -13.99999999999211 0.06693221665709047 1.9474921000553032 0.4030542773157046 0.9999344382766875 0.0008346916691838987 12.392226809946898 0.06877666870576267 1.869868947629586 0.3218342929913102 1.0000000000181687e-14 13.99999999999211 -1.5444378227395985 LSTIALALGVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSTIALALGVER 12 0 P30153;C9J9C1;E9PPI5;E9PNM7;E9PHZ6;P30154;P30154-2;P30154-4;P30154-5 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 0 32075500.0 16399000.0 7190100.0 8486400.0 False True 13636495.098879563 7151365.504176892 10260867.003319763 1.0 0.5244284145098604 0.7524563261246537 23.700969549539167 -10.061422054994688 5.087664762668333 1.0000060674688442 0.6384423703158771 0.7702261981977403 0.0930920050995847 6.4069485403313965e-06 1.1819560086794089e-06 0.0901374582632605 0.03004531545062362 8.68116368503223e-11 10.061422054994688 -0.3615636971529671 LSTIALALGVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSTIALALGVER 12 0 P30153;C9J9C1;E9PPI5;E9PNM7;E9PHZ6;P30154;P30154-2;P30154-4;P30154-5 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 0 173944000.0 53256000.0 76569000.0 44119000.0 False True 68940941.83270353 72307867.84043956 36089794.69916829 1.0 1.0488378301518773 0.5234885648465041 26.038857672346502 -6.884148104430896 1.0563531251854608 1.032312848382195 0.4831578888439031 0.9768818942340639 0.03603211243360491 0.12402090018850043 0.25059858119068945 0.026168919947491882 0.06400799811456781 1.305725529688562e-07 6.884148104430896 -0.549154959538292 LSTLILHGGGTVCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSTLILHGGGTVCR 14 0 Q9NYB0;A0A590UJT3 Q9NYB0 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 0 31530100.0 5954300.0 6419800.0 19156000.0 False True 7806144.96152322 5461990.864184407 17173920.877327144 1.0 0.6997040012844705 2.200051493019671 22.896178823457536 -6.854662071389764 1.2124145684457937 0.8388683393083886 2.265634634397748 0.9468132587890561 0.14948703306458117 0.15240447288080686 0.4287720138380833 0.09635223612067759 0.2237295851987781 1.3974553112044176e-07 6.854662071389764 1.4267662950893594 up LSTLILHGGGTVCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSTLILHGGGTVCR 14 0 Q9NYB0;A0A590UJT3 Q9NYB0 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 0 36556100.0 8304100.0 28252000.0 0.0 False True 12597926.811029278 23210209.866116464 0.0 1.0 1.8423832916536955 0.0 23.58668299908435 -6.791273629160074 1.5495930920054324 1.47503298306839 4.409597724254083e-20 0.7753818348699544 0.356907695160316 0.24108546882654808 1.1528114071652202 0.18293286926831429 0.41751568517391346 1.6170608802513807e-07 6.791273629160074 -1.47503298306839 LSTLILHGGGTVCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSTLILHGGGTVCR 14 0 Q9NYB0;A0A590UJT3 Q9NYB0 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 0 46812100.0 8304100.0 21653000.0 16855000.0 False True 10749821.148282869 20447991.515483256 13787562.94690453 1.0 1.9021703927371418 1.2825853339064062 23.3578093211768 -10.30048292029029 5.651940031417771 0.9999340871740545 1.5923778633217804 0.549307105488073 0.25294454106462383 0.00021010793371457854 2.6004394535939526e-05 0.24493956599635597 0.08163749958811035 5.006302406699409e-11 10.30048292029029 0.5924437761477259 LSTPAGVQVILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSTPAGVQVILR 12 0 M0R226;Q9BQ48 M0R226 MRPL34 Ribosomal protein L34;39S ribosomal protein L34, mitochondrial 0 5741900.0 2402400.0 1317900.0 2021600.0 False True 3149569.6648746934 1121274.4571339649 1812424.224556511 1.0 0.35600878102138284 0.575451384603242 21.586723291662747 -10.101375368465295 5.143759514459476 1.0000127482837968 0.46573008281137795 0.8876843486923134 0.08958706777061946 1.309760429392824e-05 2.2878281157145866e-06 0.0867443740469729 0.02891410179211045 7.918166533801413e-11 10.101375368465295 -0.5342826654724189 LSTPAGVQVILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSTPAGVQVILR 12 0 M0R226;Q9BQ48 M0R226 MRPL34 Ribosomal protein L34;39S ribosomal protein L34, mitochondrial 0 12793600.0 4415000.0 3951900.0 4426700.0 False True 6697877.779734627 3246652.5686643706 3551760.804708461 1.0 0.4847285476733504 0.5302815192380508 22.675272619871713 -10.048221602980417 7.641781496289865 1.000000026249366 0.5075050344795825 0.9936245119691276 0.018596922766837963 8.331290547105403e-09 1.0357961448393193e-09 0.018006394114928024 0.006002131013889079 8.949080135166705e-11 10.048221602980417 -0.4924949917697835 LSTPAGVQVILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSTPAGVQVILR 12 0 M0R226;Q9BQ48 M0R226 MRPL34 Ribosomal protein L34;39S ribosomal protein L34, mitochondrial 0 8179400.0 2402400.0 3254400.0 2522600.0 False True 3290632.2024188647 3110609.8471383466 1926813.8345778033 1.0 0.9452924714137946 0.5855451828257952 21.649933353185638 -6.933928171060129 0.7138137872866398 1.0047547003205954 0.5037166721137221 0.9972554759186492 0.009631196546131218 0.09064899114723901 0.06806051175917101 0.008989325829457523 0.03187717605104972 1.1643185827523237e-07 6.933928171060129 -0.5010380282068734 LSTPAGVQVILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSTPAGVQVILR 12 0 M0R226;Q9BQ48 M0R226 MRPL34 Ribosomal protein L34;39S ribosomal protein L34, mitochondrial 0 4280250.0 2005300.0 700750.0 1574200.0 False True 1667495.799852628 696974.9206620158 1903357.941721578 1.0 0.4179770172276379 1.1414469181210503 20.669251696827338 -6.692537958867488 1.8571673928679717 0.6359892932979305 1.139043769135294 0.38246644655010653 0.24602789473814793 0.4112184525027661 2.7517494814634333 0.10589568642726536 0.2749041803242612 2.0298410968442706e-07 6.692537958867488 0.5030544758373634 LSTRPPPNMICLLGPSYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSTRPPPNMICLLGPSYR 18 1 Q9NPI1-2;Q9NPI1;I3L4V5 Q9NPI1-2 BRD7 Bromodomain-containing protein 7 0 8762300.0 2127400.0 2713500.0 3921400.0 False True 2789042.001770909 2308656.377140155 3515651.144724922 1.0 0.8277596306094595 1.260522839918743 21.411338230219737 -6.798738196487977 1.461356613877878 0.9048143571444353 1.2662920148785943 0.8283585355733307 0.0737016641939447 0.22256911521906603 0.9385526160775819 0.03968097643964025 0.09234294861996131 1.5895046527708006e-07 6.798738196487977 0.3614776577341591 LSTRPPPNMICLLGPSYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSTRPPPNMICLLGPSYR 18 1 Q9NPI1-2;Q9NPI1;I3L4V5 Q9NPI1-2 BRD7 Bromodomain-containing protein 7 0 9324200.0 2127400.0 3170400.0 4026400.0 False True 2913957.2708233027 3030321.2448892025 3075447.2463109787 1.0 1.0399333151625187 1.055419472723445 21.47454829174263 -13.999999999999998 0.13107540158779352 0.8101921266534027 1.0768134621931968 0.9996407145691493 0.00044250369711640585 11.935381463697949 0.1126933648411498 0.5830951487540688 0.019034505705910913 1.0000000000000041e-14 13.999999999999998 0.26662133553979417 LSVACFYGGTPYGGQFER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSVACFYGGTPYGGQFER 18 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 14317100.0 4750600.0 7859400.0 1707100.0 False True 6228082.604875848 6686808.155701249 1530465.667659488 1.0 1.0736543780691465 0.245736250585584 22.570356648753073 -6.885199378897474 1.0503442923807023 1.0497378108308137 0.18087563970459228 0.9776442738075918 0.0559399055946288 0.12312550883377152 0.2452832275782179 0.04081397547840739 0.10014315676118253 1.3025686489927305e-07 6.885199378897474 -0.8688621711262214 down LSVACFYGGTPYGGQFER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSVACFYGGTPYGGQFER 18 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 8077000.0 6334000.0 1743000.0 0.0 False True 6132930.637056309 2438988.9896249226 0.0 1.0 0.3976873592680304 0.0 22.54814520363218 -8.29031702649995 0.5359018159092608 1.0330664033244354 8.518615021774456e-17 0.991936251767173 0.03691498143958938 0.1485073700136254 0.17655391774101534 0.059526949757818665 0.07126703999328708 5.12487141796874e-09 8.29031702649995 -1.0330664033244354 LSVACFYGGTPYGGQFER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSVACFYGGTPYGGQFER 18 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 22343300.0 3757400.0 11529000.0 7056900.0 False True 5700250.5027349675 9471559.873511856 5662100.621850848 1.0 1.6616041468646725 0.9933073325697152 22.442593890551088 -6.648497693462188 2.014177858390014 1.4298264524696558 0.9961274379891972 0.18793474829583212 0.28248475081914176 0.5121741189374083 3.981125976870056 0.11381801766985858 0.3128141385477857 2.2464787070076568e-07 6.648497693462188 -0.43369901448045856 LSVACFYGGTPYGGQFER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSVACFYGGTPYGGQFER 18 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 21802800.0 4750600.0 6872200.0 10180000.0 False True 6507025.200137811 6568563.480673595 7775693.663681145 1.0 1.0094572064258305 1.1949690410783202 22.633566710275964 -6.917479458402735 0.8432211764424532 0.9955232033402998 1.2232152149768851 0.9934513370141006 0.007263983743757061 0.09967767295266743 0.11347087177805712 0.006176512771650303 0.01807805544372203 1.2092623782204933e-07 6.917479458402735 0.22769201163658537 LSVACFYGGTPYGGQFER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSVACFYGGTPYGGQFER 18 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 12525950.0 6334000.0 849650.0 5342300.0 False True 5267001.643777259 845072.7668076797 6459350.229995668 1.0 0.16044664952897777 1.2263809026198271 22.328550479066458 -6.69670276247735 1.8426398952279035 0.47699673931404013 1.223020619886186 0.4019515454983358 0.35460391785541684 0.4024148599401278 2.65397081631873 0.15366431459298685 0.3967987426365245 2.010468335901184e-07 6.69670276247735 0.7460238805721457 LSVACFYGGTPYGGQFER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSVACFYGGTPYGGQFER 18 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 20153000.0 3757400.0 8995500.0 7400100.0 False True 4864028.36942692 8494892.517319985 6053357.731438047 1.0 1.7464726502655767 1.2445153012442758 22.213720212643537 -10.221631770192515 4.061397473968888 0.9996793191545104 1.4954939756695356 0.5650694168043948 0.20492323017807323 28243102.57489328 23694113.133670945 75759.31089759423 0.07015067237683444 6.002998430486882e-11 10.221631770192515 0.4958146565150252 LSVDYGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSVDYGK 7 0 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 30674300.0 2221300.0 15759000.0 12694000.0 False True 2912145.8110997984 13407818.628100872 11380546.64944615 1.0 4.604102781185015 3.907959074737464 21.473651162389668 -10.287227442739724 5.119689827595875 0.9992696784686904 4.256030927961985 0.9668531295881402 0.2841994780769827 0.002369449093628415 0.00032987974153693775 0.2752158842393223 0.09172498713237713 5.161459895916308e-11 10.287227442739724 3.256761249493294 LSVDYGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSVDYGK 7 0 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 26785700.0 7159400.0 3499300.0 16127000.0 False True 6932128.765857434 4896588.738608434 11902854.90037045 1.0 0.7063614805780047 1.7170562322781937 22.724867022457367 -6.828961975834306 1.3324727274798234 0.8429791898298138 1.7436937772310537 0.9037919164468136 0.1316728317459576 0.18209852122687767 0.6326706055667117 0.07759493112549061 0.17858289648644382 1.4826478910346003e-07 6.828961975834306 0.9007145874012399 LSVDYGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSVDYGK 7 0 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 120955400.0 2504100.0 116330000.0 2121300.0 False True 3798902.7742318204 95570002.60956147 1702024.1252011815 1.0 25.15726468648221 0.44803045151513504 21.85715135873471 -11.576952347804406 3.56475367225373e-10 8.750408811566771 14.494355027073127 0.0 11.844748202388821 1104351632.8710682 1.0619126522310094 834574419.0832422 834574424.5767365 2.648790756553876e-12 11.576952347804406 5.743946215506355 LSVDYGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSVDYGK 7 0 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 32084300.0 2221300.0 13859000.0 16004000.0 False True 3042574.638375384 13246663.554415679 12224184.812726235 1.0 4.3537678212847 4.017710743573894 21.53686122391256 -10.197629054259357 4.897607678219124 0.9996254480622727 4.185739282435793 0.9917232962409285 0.13719472749616002 0.0005611491676005608 9.19319983710223e-05 0.13285140562932535 0.04427940789514087 6.344113522971258e-11 10.197629054259357 3.1861138343735202 LSVDYGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSVDYGK 7 0 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 10554700.0 7159400.0 2204900.0 1190400.0 False True 5953358.315197181 2193021.7660616143 1439307.136212274 1.0 0.3683671719310883 0.24176390198757972 22.505272297891644 -13.999999999999998 0.2259491573913345 4.914008795228158 0.1777868008850756 0.9995045374455613 0.0073821348500586435 13.168350135978812 0.15053774778183693 23.070907259793632 0.06741540226162968 1.0000000000000041e-14 13.999999999999998 -4.736221994343082 LSVDYGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSVDYGK 7 0 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 8570200.0 2504100.0 3383300.0 2682800.0 False True 3241606.813190493 3195016.380840278 2194557.927852594 1.0 0.9856273647499035 0.6769969506858976 21.62827768082716 -6.916622735385422 0.849392484465845 1.007673305047412 0.6308975675948069 0.9931903069460977 0.012295031290536352 0.10020000127923029 0.11621057271424229 0.010408163011376785 0.030238411817109487 1.2116502175294356e-07 6.916622735385422 -0.3767757374526052 LSVDYGK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSVDYGKK 8 1 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 214637000.0 69919000.0 102070000.0 42648000.0 True False 91664486.09655924 86841553.86574377 38235194.06850326 1.0 0.9473849422366805 0.4171211305131451 26.44985955772306 -6.9260690471915485 0.7783816861584729 1.0093462305873109 0.3184117155279138 0.9957076541317086 0.017246957618290724 0.09473093444732214 0.08806044053369026 0.0153597868273035 0.04905757798665423 1.1855802412963828e-07 6.9260690471915485 -0.6909345150593971 down LSVDYGK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSVDYGKK 8 1 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 165504000.0 69919000.0 56750000.0 38835000.0 True False 95769943.78992875 54242597.35284575 29662972.83193093 1.0 0.5663843498940212 0.30973154685144877 26.51306961924595 -8.827356464782605 0.18783895814888962 1.3901468735041294 5.052275901629102e-22 0.999698921435636 0.004942969908023211 0.3416484646763841 0.05658806753476759 0.22066992976738165 0.14130043146419427 1.488139125847136e-09 8.827356464782605 -1.3901468735041294 down LSVDYGK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSVDYGKK 8 1 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 204521000.0 55291000.0 110960000.0 38270000.0 True False 45976916.30661324 110362236.4561644 46272080.05951253 1.0 2.40038361251057 1.0064198249167233 25.45440637127794 -6.645161525074734 2.0263482950495204 1.9121899138024672 1.0123182596354179 0.17449811834948592 0.5984207130762725 0.5204636093769485 4.090702462939167 0.24000186345926058 0.6625061858989999 2.263802185852709e-07 6.645161525074734 -0.8998716541670493 LSVDYGK(ub)K(ub)SK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSVDYGKKSK 10 2 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 2 56331000.0 23659000.0 22377000.0 10295000.0 True False 31017178.114081923 19038438.824862827 9229772.156613227 1.0 0.613803059544585 0.2975696925963382 24.88656410280972 -7.728521204113129 0.2554468761720688 1.1453251313923125 6.236837185082783e-11 0.9997354868544976 0.004671623198170968 0.1263573361391884 0.03517409095681477 0.042058712166939384 0.08124119420041535 1.868438449876491e-08 7.728521204113129 -1.1453251313299442 down LSVDYGK(ub)K(ub)SK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSVDYGKKSK 10 2 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 2 50435000.0 18331000.0 18232000.0 13872000.0 True False 17749092.43888209 25512132.678623997 10238507.048920382 1.0 1.4373767428657809 0.5768467928248192 24.081241921651475 -6.768507345277527 1.5799753671228662 1.251338628727274 0.5722534245070462 0.7249195410534215 0.18426379399781873 0.26883317523473443 1.3241694799539596 0.09193561340743577 0.21916304274035736 1.704090497573588e-07 6.768507345277527 -0.6790852042202279 LSVDYGK(ub)K(ub)SK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSVDYGKKSK 10 2 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 2 48836000.0 23659000.0 14380000.0 10797000.0 True False 32406371.660434548 13744644.051699061 8246970.971195012 1.0 0.42413400042807364 0.2544860948214042 24.949774164332613 -13.999999999998492 0.1713186244474358 3.9142695621965586 0.10691876525304242 0.9995112243597736 0.00705386058106731 12.10462344686684 0.13109617272200674 11.724769199846897 0.13666881620611912 1.0000000000034726e-14 13.999999999998492 -3.807350796943516 LSVDYGK(ub)K(ub)SK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSVDYGKKSK 10 2 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 2 53751000.0 18331000.0 24173000.0 11247000.0 True False 15243038.700991616 24042775.25103518 13598695.699747538 1.0 1.57729542794319 0.8921249867890773 23.86164719708575 -6.683325003963642 1.890239401248926 1.3641670304860998 0.8946709478689452 0.339359137027459 0.24449566418193872 0.43116305555998125 2.981330903092036 0.1036850892035814 0.27228654396114516 2.0733613382727572e-07 6.683325003963642 -0.4694960826171546 LSVDYGK(ub)K(ub)SK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSVDYGKKSK 10 2 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 2 100596000.0 36763000.0 20665000.0 43168000.0 True False 47590428.207069255 19514974.584005076 35311866.94108427 1.0 0.41006091601222977 0.7419951505256454 25.504168099786554 -10.206232853436743 5.679854076865999 1.000013147875356 0.5760280332689546 0.6850640436666677 0.13551158378658384 2.256232367340591e-05 3.1529709747276353e-06 0.13121259161690663 0.043736175601961746 6.219667190598796e-11 10.206232853436743 -0.4239851146064014 LSVDYGKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSVDYGKK 8 1 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 8350800.0 1328300.0 3035300.0 3987200.0 False True 1741414.1632755 2582445.071506731 3574642.79192309 1.0 1.4829585781301446 2.052724083281482 20.7318279315576 -6.9689408589508535 0.28233794184266137 0.8779591830850635 2.6751411907175187 0.9999729028410846 0.002239705826773566 0.07664789022868387 0.010254636574004336 0.010384517123946278 0.05214477746602202 1.0741356752762774e-07 6.9689408589508535 1.7971820076324552 LSVDYGKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSVDYGKK 8 1 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 3331920.0 1093100.0 584120.0 1654700.0 False True 1058400.138832689 817362.1621455583 1221284.430064055 1.0 0.7722619566613323 1.1538967024428126 20.013453725294916 -6.745064782125219 1.668007490824187 0.8652969252910024 1.1543828936016474 0.6274883905743625 0.095683094984383 0.3087432494400206 1.6884318468933168 0.04534496108285133 0.11066618652957393 1.7986026041217694e-07 6.745064782125219 0.2890859683106449 LSVDYGKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSVDYGKK 8 1 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 53348000.0 1272700.0 47994000.0 4081300.0 False True 1930778.946833126 39429095.72116648 3274629.266102666 1.0 20.42134123424035 1.69601459114402 20.880751570193308 -6.4333946344811626 2.976590228889355 9.999999999999998 1.604706016082433 0.2185640376774296 7.952136279662333 0.6992544036704541 11.332592344641276 3.0448353334974474 11.52895191436847 3.6864246848611984e-07 6.4333946344811626 -8.395293983917565 LSVDYGKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSVDYGKK 8 1 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 10019400.0 1328300.0 4918800.0 3772300.0 False True 1819408.4059577854 4701471.151703572 2881360.4329572064 1.0 2.584065862457413 1.5836798508361187 20.79503799308049 -10.15703476297837 6.690059398951157 0.9999975140591892 2.0838728566467664 0.6101615673134995 0.4084058790483571 1.5143393707802292e-05 1.9077796223938747e-06 0.39543819886606957 0.13181243067062376 6.965707550710784e-11 10.15703476297837 1.0838753425875771 LSVDYGKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSVDYGKK 8 1 P68363;C9JDS9;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 6606100.0 1272700.0 2206700.0 3126700.0 False True 1647535.238667599 2083895.2051547994 2557672.682651228 1.0 1.2648562265897847 1.5524236584582427 20.651877892285757 -6.970073014480588 0.2564394928897807 0.9156734268089326 1.9100987377014587 0.9999829450228076 0.0009316143768845836 0.07627904274619308 0.008945491628355123 0.006143949335237661 0.027279923949368574 1.071339174352906e-07 6.970073014480588 0.9944253108925261 LSVEHK(ub)QRPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSVEHKQRPK 10 2 Q13045;Q13045-2;Q13045-3 Q13045 FLII Protein flightless-1 homolog 1 7032500.0 1976800.0 2925600.0 2130100.0 True False 2591603.9433584325 2489111.883899483 1909697.6853620051 1.0 0.9604522675150234 0.7368786771049777 21.305413827434382 -6.93710750540563 0.6859434671218365 1.0026789805525986 0.6813940649385679 0.99775998117903 0.005482838508029214 0.08911134778602667 0.06080640635078217 0.005226691829901665 0.01950037321933424 1.1558260931876503e-07 6.93710750540563 -0.3212849156140307 LSVEHK(ub)QRPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSVEHKQRPK 10 2 Q13045;Q13045-2;Q13045-3 Q13045 FLII Protein flightless-1 homolog 1 11592200.0 1858100.0 3679900.0 6054200.0 True False 1799115.632572517 5149303.260424981 4468423.397893154 1.0 2.8621302417688974 2.4836777119788853 20.778856483638872 -10.17019060043801 5.108356702222028 0.9999035041567252 2.6729039768755007 0.9630355391207923 0.1545025983140982 0.0001698055149829761 2.758338313336673e-05 0.14960492711253434 0.04986549918388558 6.757863254373177e-11 10.17019060043801 1.6730004727187755 LSVEHK(ub)QRPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSVEHKQRPK 10 2 Q13045;Q13045-2;Q13045-3 Q13045 FLII Protein flightless-1 homolog 1 8896700.0 1265600.0 2020100.0 5611000.0 True False 1920007.7277535996 1659597.3718866587 4501983.39061134 1.0 0.8643701522120331 2.344773578530666 20.872680686921314 -6.884501742854906 1.0543268648830066 0.9096598336563991 2.45920435634564 0.9771407741922595 0.10102675325208349 0.12371917585320374 0.24879823921068672 0.07348553793486295 0.1799314367475364 1.304662732924265e-07 6.884501742854906 1.5495445226892408 up LSVEHK(ub)QRPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSVEHKQRPK 10 2 Q13045;Q13045-2;Q13045-3 Q13045 FLII Protein flightless-1 homolog 1 6972000.0 1858100.0 3373800.0 1740100.0 True False 1545092.4777869463 3355624.669753134 2103946.864686644 1.0 2.171795357232878 1.3616964000110539 20.55926175907315 -10.205183907711662 4.7930419687577075 0.999881132383778 1.7667458786244148 0.5443035323897967 0.3307215144008031 0.0004201520834701331 6.967315696596408e-05 0.32026881058466283 0.10673990979103537 6.234707626773757e-11 10.205183907711662 0.7668647462406368 LSVEHK(ub)QRPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSVEHKQRPK 10 2 Q13045;Q13045-2;Q13045-3 Q13045 FLII Protein flightless-1 homolog 1 3189080.0 1265600.0 1125700.0 797780.0 True False 1638344.1487056767 1063053.8054301706 652592.2259140613 1.0 0.6488586700602578 0.39832426320783804 20.643807009013763 -7.9383065351030035 0.17714066727992994 1.2865020172392718 2.721881111095744e-15 0.999912661241352 0.0023062343149123925 0.1126132486733695 0.02862604782404365 0.0773605603175426 0.10294727961836875 1.1526394110490326e-08 7.9383065351030035 -1.2865020172392692 down LSVHFHPSVALFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSVHFHPSVALFAK 14 0 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 0 57533000.0 21182000.0 11471000.0 24880000.0 False True 20509589.004440572 16051430.120474761 18363181.61599908 1.0 0.7826305108795419 0.8953461530615378 24.28979524587833 -10.108834344859144 4.502403262467283 1.0000141067206763 0.8389883319642405 0.7312353572686504 0.04601596825898085 37624436679.02922 7446921533.37521 6342879.743999178 0.015751663338442693 7.783333780632262e-11 10.108834344859144 -0.16102577475643576 LSVHFHPSVALFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSVHFHPSVALFAK 14 0 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 0 310963000.0 77850000.0 80433000.0 152680000.0 False True 118104141.59735921 66079102.7241026 122502731.07797888 1.0 0.5594986071646798 1.0372433127333955 26.815484316189647 -6.664317160702238 1.9572856678873118 0.7174766514376355 1.035283450946303 0.2542734993457758 0.1873620563752274 0.474266800544444 3.4970135835343275 0.07721272781240741 0.2078515082316781 2.1661216311641596e-07 6.664317160702238 0.3178067995086674 LSVHFHPSVALFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSVHFHPSVALFAK 14 0 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 0 49232000.0 21182000.0 11456000.0 16594000.0 False True 17613771.521706622 11394284.25416204 20063728.67801285 1.0 0.6468963356382876 1.1390932744464741 24.070200521312607 -6.714164877095914 1.7804799235260629 0.7838476616001798 1.1380786136136036 0.48480438274312776 0.14870304128177247 0.3667641517500048 2.2689437689287137 0.06640217284110018 0.16783862642733285 1.9312349969285724e-07 6.714164877095914 0.3542309520134238 LSVHFHPSVALFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSVHFHPSVALFAK 14 0 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 0 291012000.0 77850000.0 128910000.0 84252000.0 False True 100778359.65292114 121736045.17900266 68919000.4985227 1.0 1.2079581925947138 0.6838670597128044 26.586610638282096 -6.799043496516053 1.4598391396900874 1.114879090867997 0.6768039474061539 0.8293469719976234 0.08901233389195543 0.22212477812824094 0.9346630832562325 0.04797062125576547 0.1116264107077577 1.5883876565715186e-07 6.799043496516053 -0.4380751434618432 LSVILGLLKPDLYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSVILGLLKPDLYK 14 1 E5RIH5;Q6NXR4 E5RIH5 TTI2 TELO2-interacting protein 2 0 13047300.0 5163100.0 4621900.0 3262300.0 False True 4999200.216638048 6467448.7728900835 2407805.76309782 1.0 1.2936966899956308 0.4816381938623503 22.253265877055057 -6.808873534613365 1.4193154827590808 1.1602783297181178 0.4678029823919953 0.8568425099255577 0.12702508211375882 0.20834834803027022 0.8274284538793197 0.07037711343998226 0.16287746529812439 1.552839126710137e-07 6.808873534613365 -0.6924753473261225 down LSVILGLLKPDLYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSVILGLLKPDLYK 14 1 E5RIH5;Q6NXR4 E5RIH5 TTI2 TELO2-interacting protein 2 0 103379000.0 25281000.0 50051000.0 28047000.0 False True 38353125.28866843 41119007.999752104 22503498.156563222 1.0 1.07211622756336 0.5867448346696263 25.192840807904595 -6.869103343280747 1.1388866288013364 1.0405699820137873 0.5588063718145637 0.9637770518927103 0.040699621238692106 0.13771442160780434 0.3344157970076663 0.02774996549467084 0.06559610140778874 1.3517508667485067e-07 6.869103343280747 -0.48176361019922354 LSVILGLLKPDLYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSVILGLLKPDLYK 14 1 E5RIH5;Q6NXR4 E5RIH5 TTI2 TELO2-interacting protein 2 0 6557880.0 487180.0 2214500.0 3856200.0 False True 667303.6115444646 2116656.067627786 2945444.9809319424 1.0 3.171953562080709 4.41395030683972 19.347983786384834 -8.612750321769168 0.2610397124909726 3.0512523552881326e-17 5.277869974539736 0.9991661490278136 0.04074096437496566 0.22201731491748775 0.07505272505443543 0.654362322063018 0.46912629505564885 2.439212731850211e-09 8.612750321769168 5.277869974539736 LSVILGLLKPDLYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSVILGLLKPDLYK 14 1 E5RIH5;Q6NXR4 E5RIH5 TTI2 TELO2-interacting protein 2 0 12291400.0 5163100.0 2472500.0 4655800.0 False True 4293346.414112146 2459180.151747173 5629306.254013027 1.0 0.5727886628630515 1.3111698221018475 22.033671152489333 -6.749829496865567 1.6504331809764337 0.7487440142182681 1.312621840576819 0.6482500319752765 0.1795156897914981 0.300345049752616 1.609590027357244 0.08592395740651058 0.20864098159187963 1.778977695999308e-07 6.749829496865567 0.563877826358551 LSVILGLLKPDLYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSVILGLLKPDLYK 14 1 E5RIH5;Q6NXR4 E5RIH5 TTI2 TELO2-interacting protein 2 0 75243000.0 25281000.0 25866000.0 24096000.0 False True 32726752.863012187 24426534.361958608 19710775.24583875 1.0 0.7463781837508696 0.6022832551809896 24.963967129997044 -13.999999999999998 0.065075805384505 2.5328637797776135 0.021809643159407338 0.9999401297274273 0.0012720980369891886 12.411486496280725 0.06715811942549221 2.9837794328861817 0.5390863817876491 1.0000000000000041e-14 13.999999999999998 -2.511054136618206 LSVLGAITSVQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSVLGAITSVQQR 13 0 P62495;B7Z7P8;P62495-2;I3L492;D6RJE8;D6RCB3 P62495 ETF1 Eukaryotic peptide chain release factor subunit 1 0 60606000.0 19908000.0 19361000.0 21337000.0 False True 26099580.789346248 16472414.268586924 19129251.918956414 1.0 0.6311371206127151 0.7329333016247105 24.63752329866998 -10.172277263599439 7.648260618754253 1.000000148504571 0.6820352111187138 0.9286157762237746 0.04155811687389707 1.0527500722312561e-07 1.136756215472781e-08 0.04023849222541329 0.013412824546028731 6.725471496057559e-11 10.172277263599439 -0.3179649373858573 LSVLGAITSVQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSVLGAITSVQQR 13 0 P62495;B7Z7P8;P62495-2;I3L492;D6RJE8;D6RCB3 P62495 ETF1 Eukaryotic peptide chain release factor subunit 1 0 45318000.0 17046000.0 11142000.0 17130000.0 False True 16504884.060508654 15591058.70476242 12643139.111015428 1.0 0.9446330339312864 0.7660241092675563 23.97638966851469 -6.9498083457042 0.5609476708999166 1.0023244827595617 0.699782817102108 0.9991861262010915 0.0028482632286443697 0.08356287515722409 0.036282147038327286 0.0030496922764274275 0.014850305722231692 1.1225137106803232e-07 6.9498083457042 -0.30254166565745366 LSVLGAITSVQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSVLGAITSVQQR 13 0 P62495;B7Z7P8;P62495-2;I3L492;D6RJE8;D6RCB3 P62495 ETF1 Eukaryotic peptide chain release factor subunit 1 0 47961000.0 10301000.0 20417000.0 17243000.0 False True 15627370.10397425 16773426.831250904 13834913.492124632 1.0 1.0733365063764118 0.885300175274292 23.89757167497457 -6.800978279805438 1.452354477127812 1.0404130146207804 0.8826545248792662 0.8348797250535303 0.03144422600099296 0.21937143844304172 0.9135028249450543 0.017033150655870275 0.039581664173646135 1.5813271235676762e-07 6.800978279805438 -0.15775848974151419 LSVLGAITSVQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSVLGAITSVQQR 13 0 P62495;B7Z7P8;P62495-2;I3L492;D6RJE8;D6RCB3 P62495 ETF1 Eukaryotic peptide chain release factor subunit 1 0 62068000.0 19908000.0 14861000.0 27299000.0 False True 27268525.593471024 14204391.881244797 20851538.4405532 1.0 0.5209079542109821 0.7646742163993545 24.70073336019287 -10.274477875151122 4.886676370114988 1.0001017481732832 0.6427910853048718 0.7411403579539859 0.09951715981228912 0.00011034860088296236 1.638334611409801e-05 0.09638439361789392 0.032119025217745144 5.315230769131023e-11 10.274477875151122 -0.3573106628684114 LSVLGAITSVQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSVLGAITSVQQR 13 0 P62495;B7Z7P8;P62495-2;I3L492;D6RJE8;D6RCB3 P62495 ETF1 Eukaryotic peptide chain release factor subunit 1 0 30291000.0 17046000.0 6379600.0 6865400.0 False True 14174504.265839458 6345231.8285485525 8300923.397976954 1.0 0.44765105781092857 0.58562354226258 23.756794943948965 -10.205054645656478 8.136054037465703 1.0000001646473615 0.5166373000368806 0.9424109026585382 0.0563270309084386 1.6827014568463088e-07 1.63814722916915e-08 0.054538431853673665 0.018179471054141097 6.236563581894606e-11 10.205054645656478 -0.48336286461048095 LSVLGAITSVQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSVLGAITSVQQR 13 0 P62495;B7Z7P8;P62495-2;I3L492;D6RJE8;D6RCB3 P62495 ETF1 Eukaryotic peptide chain release factor subunit 1 0 52577000.0 10301000.0 27339000.0 14937000.0 False True 13334847.563066656 25817560.617087565 12218619.266562616 1.0 1.9360971690890647 0.9162923842042529 23.66869799706702 -6.665286596274553 1.9538119424044902 1.5998913524901377 0.9204602864762839 0.258501799840794 0.3980666620926898 0.4720001698537502 3.4689184579442607 0.16427890843309542 0.44167084454154193 2.1612917899626054e-07 6.665286596274553 -0.6794310660138538 LSVLIHNSDEHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSVLIHNSDEHK 12 0 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578;C9JWF0;C9IYK2;C9JJ64 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 23949800.0 6044500.0 8580600.0 9324700.0 False True 7924398.035021264 7300407.926916838 8359869.492838406 1.0 0.9212570967098384 1.0549532539749529 22.917869916579487 -6.747130085711081 1.6607472308625988 0.9535384452164443 1.0551573949616158 0.6364175687453548 0.033084494411543604 0.3050757403730947 1.6546314871571837 0.015744160350932516 0.038334257073021 1.7900695880602902e-07 6.747130085711081 0.1016189497451715 LSVLIHNSDEHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSVLIHNSDEHK 12 0 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578;C9JWF0;C9IYK2;C9JJ64 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 16637600.0 4041500.0 2323100.0 10273000.0 False True 3913204.7947052578 3250725.944806457 7582193.116606056 1.0 0.8307068286343806 1.9375916964185222 21.89991918392636 -6.8678939529918965 1.1452393754942574 0.9053791328015718 1.99985701470347 0.9625324496178916 0.0942312491086041 0.13888692603354708 0.34178201710940226 0.06393690659058904 0.15083742313551574 1.35552036596935e-07 6.8678939529918965 1.094477881901898 LSVLIHNSDEHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSVLIHNSDEHK 12 0 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578;C9JWF0;C9IYK2;C9JJ64 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 23122700.0 5894200.0 12621000.0 4607500.0 False True 8941932.323739935 10368683.941676918 3696825.6054610102 1.0 1.1595574162587992 0.41342580905542176 23.0921551963304 -6.850777079348938 1.231309426258687 1.0852071682022082 0.38314451483622697 0.9414294893337363 0.07763902422555498 0.1566069522058409 0.45651071952434213 0.049329075575455565 0.11421028691788518 1.4100123632642714e-07 6.850777079348938 -0.7020626533659813 down LSVLIHNSDEHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSVLIHNSDEHK 12 0 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578;C9JWF0;C9IYK2;C9JJ64 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 20501000.0 6044500.0 5611000.0 8845500.0 False True 8279314.99647054 5363087.4669042835 6756375.07879092 1.0 0.6477694675453899 0.8160548404875467 22.98107997810238 -10.087340163345404 4.827433854317226 1.000010531058931 0.7319121540138052 0.7718856030078407 0.06870221582288659 7.787147658921745e-06 1.4723580453071304e-06 0.06652324645980623 0.022173544809493417 8.178239724514395e-11 10.087340163345404 -0.26809837704512574 LSVLIHNSDEHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSVLIHNSDEHK 12 0 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578;C9JWF0;C9IYK2;C9JJ64 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 12590000.0 4041500.0 5496900.0 3051600.0 False True 3360686.3188073593 5467287.108650781 3689675.450995786 1.0 1.6268364821954024 1.0978934363339148 21.680324459360637 -10.288641226305835 4.592697700201214 0.9998040747945842 1.3623649592659948 0.3849060609705143 0.21594009423026422 0.0004334367637089542 6.713525056861597e-05 0.20919523173292506 0.06969436572704617 5.144684820742656e-11 10.288641226305835 0.36256088447141055 LSVLLLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSVLLLEK 8 0 Q3LXA3;H0YCY6;Q3LXA3-2;I3L252 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 10231000.0 3177900.0 3383000.0 3670100.0 False True 4166257.674827374 2878269.5868307143 3290353.258085105 1.0 0.6908525135690206 0.7897623034613284 21.99032063930751 -10.594693737243242 9.303912016256163 1.0000440074041688 0.7403074085151745 0.9018775697007755 0.04037975263367454 3.686636091225836e-05 1.6060227242259535e-06 0.039104118167595354 0.013032509122849707 2.5427652214486684e-11 10.594693737243242 -0.25973659888899425 LSVLLLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSVLLLEK 8 0 Q3LXA3;H0YCY6;Q3LXA3-2;I3L252 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 13632500.0 5864100.0 3267300.0 4501100.0 False True 5677947.3553460585 4571949.928744407 3322126.879894431 1.0 0.8052117504118277 0.5850929344680328 22.436938042103762 -6.969536587917714 0.26902317871455533 1.0553719774449788 0.32832389129073636 0.9999785385441149 0.0007851681503527432 0.07645337467901328 0.009566881819635963 0.00434077737214925 0.020499922707385466 1.0726632755868812e-07 6.969536587917714 -0.7270480861542424 LSVLLLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSVLLLEK 8 0 Q3LXA3;H0YCY6;Q3LXA3-2;I3L252 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 15204700.0 3095700.0 9168900.0 2940100.0 False True 4696403.225985163 7532638.158057324 2358987.9463083916 1.0 1.6039164006146862 0.5022967221502893 22.1631248506757 -6.757854508529714 1.620444752253844 1.351725157586564 0.49868156320849844 0.6821666985223506 0.25393793360944955 0.28654793418492314 1.482445601639736 0.12367126620258447 0.29784660316598566 1.7464071126504134e-07 6.757854508529714 -0.8530435943780657 LSVLLLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSVLLLEK 8 0 Q3LXA3;H0YCY6;Q3LXA3-2;I3L252 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 17042900.0 3177900.0 6303900.0 7561100.0 False True 4352855.509518358 6025372.853790394 5775323.90574258 1.0 1.3842345192976782 1.3267897115155145 22.0535307008304 -10.121722430177313 4.508633244751407 0.9999610038488262 1.3555121154181928 0.9807942204628836 0.023451744612517283 12366657.779826066 0.3480848085996907 5006.52927352469 0.008582459723017154 7.555749826080988e-11 10.121722430177313 0.3555511115693666 LSVLLLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSVLLLEK 8 0 Q3LXA3;H0YCY6;Q3LXA3-2;I3L252 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 9819600.0 5864100.0 1507300.0 2448200.0 False True 4876258.973677652 1499179.875724375 2960107.300802158 1.0 0.3074446791725052 0.6070447276859168 22.217343317538038 -10.472844618171445 6.181513742510199 1.000299216702892 0.45724470342965384 0.813983145988096 0.12231120762849082 0.0005046381238507848 4.303520696549043e-05 0.1184904422936768 0.0394757725166385 3.3663198798551854e-11 10.472844618171445 -0.5430545132732381 LSVLLLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSVLLLEK 8 0 Q3LXA3;H0YCY6;Q3LXA3-2;I3L252 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 12061200.0 3095700.0 5374400.0 3591100.0 False True 4007444.675369917 5075309.915522715 2937556.647797622 1.0 1.2664703636998373 0.7330248788840643 21.93425117276815 -6.770854088767603 1.570934509732832 1.152668040221248 0.7299076534321169 0.7339449728662897 0.11233115320060032 0.2650294339692776 1.2908664136954813 0.056356190127102454 0.13405996362831424 1.6949071478869825e-07 6.770854088767603 -0.42276038678913097 LSVNSHFMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LSVNSHFMK 9 0 O14561;I3L505 O14561 NDUFAB1 Acyl carrier protein, mitochondrial;Acyl carrier protein 0 34630140.0 11077040.0 11181100.0 12372000.0 False True 14522106.71020796 9512923.463586438 11091864.12060405 1.0 0.6550649746224191 0.7637916689323936 23.79174742332355 -10.636883160173841 9.594591241113092 1.0000953444967555 0.7094283217774064 0.904969895305807 0.044387487079834115 9.055770952084714e-05 3.4272186042252194e-06 0.042991910968271645 0.014325999853349536 2.3073678648050096e-11 10.636883160173841 -0.2906670227193491 LSVNSHFMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSVNSHFMK 9 0 O14561;I3L505 O14561 NDUFAB1 Acyl carrier protein, mitochondrial;Acyl carrier protein 0 15438600.0 4571700.0 1707500.0 9159400.0 False True 4426573.885922056 2389313.654494869 6760278.363889944 1.0 0.5397659038503035 1.5272033265704266 22.077759071683595 -6.77993680757179 1.5358820006652387 0.7393881446009738 1.5350454648230722 0.7672638786677165 0.19462496037762694 0.2506608457812668 1.1678762685816708 0.09980242743733486 0.23552737233993207 1.659828404765049e-07 6.77993680757179 0.7956573202220985 LSVNSHFMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSVNSHFMK 9 0 O14561;I3L505 O14561 NDUFAB1 Acyl carrier protein, mitochondrial;Acyl carrier protein 0 20205700.0 5243700.0 9743200.0 5218800.0 False True 7955076.2658198085 8004449.836030938 4187301.8925187057 1.0 1.006206548945768 0.5263685416204095 22.923444331155494 -6.9039701394689335 0.9358209614032255 1.017835478486354 0.47173414768259364 0.9884402615259668 0.024164183819624093 0.10854185606601326 0.1613941092654513 0.019211736703977286 0.05105909774088656 1.24746928280843e-07 6.9039701394689335 -0.5461013308037603 LSVNSHFMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSVNSHFMK 9 0 O14561;I3L505 O14561 NDUFAB1 Acyl carrier protein, mitochondrial;Acyl carrier protein 0 21868100.0 9524800.0 4234100.0 8109200.0 False True 13046375.958041638 4047023.4617036846 6193973.974216415 1.0 0.31020288505553495 0.47476586556579486 23.637145772656602 -10.434360015479326 9.092863744818981 1.0000043678744364 0.39248437531526664 0.9478390777392907 0.06718255546695162 5.948859042568163e-06 3.700176545648735e-07 0.06504969725144222 0.021683076539929968 3.678239335896107e-11 10.434360015479326 -0.6075199925591697 LSVNSHFMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSVNSHFMK 9 0 O14561;I3L505 O14561 NDUFAB1 Acyl carrier protein, mitochondrial;Acyl carrier protein 0 13440400.0 4571700.0 5546700.0 3322000.0 False True 3801571.1106499005 5516818.826166255 4016614.8408074393 1.0 1.4511944313526528 1.056567067640825 21.85816434711787 -10.359082029145403 6.173938083983743 0.9999719687863519 1.253880749496739 0.35560932154241987 0.16110594660561506 6.21677829767748e-05 6.453733389717301e-06 0.15600736074700253 0.05199672068154397 4.3743947418619086e-11 10.359082029145403 0.25390878071038714 LSVNSHFMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSVNSHFMK 9 0 O14561;I3L505 O14561 NDUFAB1 Acyl carrier protein, mitochondrial;Acyl carrier protein 0 18812900.0 5243700.0 8281500.0 5287700.0 False True 6788073.01877999 7820627.244976424 4325392.856383692 1.0 1.1521130110621605 0.6372048215181232 22.694570653247943 -6.827597777225095 1.3387888536849313 1.0814219988310239 0.6240338853761525 0.9009472594391639 0.06797971192298538 0.18379691606672915 0.6451471291419896 0.039879460782993426 0.09177928841150364 1.4873124822832486e-07 6.827597777225095 -0.4573881134548714 LSVTATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSVTATR 7 0 P22695;H3BRG4;H3BSJ9;H3BP04 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 8906600.0 3333800.0 2375000.0 3197800.0 False True 4370644.084565125 2020659.2576774906 2866922.3314636014 1.0 0.46232528171612586 0.6559496211526584 22.059414468989885 -10.117804017656946 5.049019470289229 1.0000153066532973 0.5591374514343025 0.8736151780383526 0.07904680557088177 110240803.65245749 5.523710871186604 19853.786779980517 0.027059824068118937 7.62422987995364e-11 10.117804017656946 -0.4408778552189948 LSVTATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSVTATR 7 0 P22695;H3BRG4;H3BSJ9;H3BP04 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 9025900.0 3333800.0 2342000.0 3350100.0 False True 4566395.952557449 2238522.696041669 2558875.3774752603 1.0 0.4902165119492026 0.5603708929450457 22.122624530512777 -10.552122369179754 6.338119793772766 1.0006882130699464 0.5252937024472617 0.9838837251461725 0.02864040611010346 0.00027890066466233304 1.9708263664610204e-05 0.027768345313445512 0.009243651324420654 2.8046432750363834e-11 10.552122369179754 -0.4753945106226847 LSVTVDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSVTVDPK 8 0 A0A024R4E5;Q00341;Q00341-2;H0Y394 A0A024R4E5 HDLBP Vigilin 0 7759600.0 2386200.0 2379500.0 2993900.0 False True 3128331.307993674 2024487.8752183556 2684119.947516687 1.0 0.6471462501574815 0.8580037353006968 21.576961879631966 -10.285928939916076 5.598664500558552 1.0000248656202473 0.7525749927290847 0.6473776535396871 0.08608220784124315 2.672035511278657e-05 3.4081065472214747e-06 0.08335710731987145 0.027782913114489355 5.176915306877576e-11 10.285928939916076 -0.2474498728911626 LSVTVDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSVTVDPK 8 0 A0A024R4E5;Q00341;Q00341-2;H0Y394 A0A024R4E5 HDLBP Vigilin 0 6864400.0 2386200.0 2043200.0 2435000.0 False True 3268442.62463033 1952924.6680411347 1859903.1503991727 1.0 0.5975092398209119 0.5690487378861463 21.640171941154858 -13.999999999999998 0.3761205950510489 6.826841974901457 0.566376683719322 0.999801190652375 0.002774692878045671 23.552344074383125 0.19963147062186018 110.94085949945564 0.007805141554325092 1.0000000000000041e-14 13.999999999999998 -6.260465291182135 LSVTVDPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSVTVDPK 8 0 A0A024R4E5;Q00341;Q00341-2;H0Y394 A0A024R4E5 HDLBP Vigilin 0 2830810.0 982100.0 1331600.0 517110.0 False True 816659.6644069548 1324426.406498095 625235.3101535022 1.0 1.6217605254936551 0.7656008217419897 19.63937544782841 -6.711993956798804 1.7887236605009393 1.3814775798043695 0.76754606947815 0.47430336001721385 0.26192682959727975 0.3710701397368481 2.3156900119706334 0.11649217394690572 0.29516217403816086 1.9409128851785315e-07 6.711993956798804 -0.6139315103262195 LSVVFGEHTLLVTVSGQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSVVFGEHTLLVTVSGQR 18 0 A0A087WVU0;A0A087WT92;Q0VGL1 A0A087WVU0 LAMTOR4 Ragulator complex protein LAMTOR4;Ragulator complex protein LAMTOR4, N-terminally processed 0 173085000.0 34923000.0 59917000.0 78245000.0 False True 52980744.21328928 49224343.21634232 62779841.453998275 1.0 0.929098749881193 1.1849558247286958 25.658964773401912 -6.832799621998141 1.3154910812090739 0.962183510084653 1.1922361054488695 0.9113336839968196 0.03211650470560833 0.1773827292876384 0.5993657872054128 0.019163865230997137 0.04409840274935558 1.4696041780953048e-07 6.832799621998141 0.23005259536421652 LSVVFGEHTLLVTVSGQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSVVFGEHTLLVTVSGQR 18 0 A0A087WVU0;A0A087WT92;Q0VGL1 A0A087WVU0 LAMTOR4 Ragulator complex protein LAMTOR4;Ragulator complex protein LAMTOR4, N-terminally processed 0 128352000.0 34923000.0 55937000.0 37492000.0 False True 45208511.935246766 52824056.77742522 30668840.700406116 1.0 1.1684537826214316 0.6783864229889679 25.43009109549436 -6.813937369594708 1.3981862655421249 1.091387029697351 0.6690410884310084 0.8697928141235524 0.07335924285092406 0.20148428479693564 0.7755743267431235 0.04124908493445432 0.09524684568182024 1.5348383086929098e-07 6.813937369594708 -0.4223459412663425 LSVYAALQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LSVYAALQR 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 8224500.0 1316100.0 3458900.0 3449500.0 False True 1725419.8451305279 2942845.602686603 3092578.829940484 1.0 1.7055823317390773 1.7923630811760662 20.718516023845982 -11.259480505013531 0.3672852394451699 2.8433199634774386e-10 1.8035760548996398 0.999503586993014 0.00790599736539136 3.3511571813802368 0.18494114419245383 2.754071934921794 0.024414307326016335 5.501986177479976e-12 11.259480505013531 1.803576054615308 LSVYAALQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSVYAALQR 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 6426700.0 2732100.0 2040000.0 1654600.0 False True 2645370.9809759283 2854582.6384594594 1221210.6230639894 1.0 1.079085942572164 0.46164059099698046 21.335038626213183 -6.874734543531738 1.1088114826996711 1.0462981450490196 0.42208217430873707 0.9691811069690596 0.04815989782939926 0.13239310622353442 0.3013808809543524 0.03360303711939476 0.0802746801449827 1.334336777770618e-07 6.874734543531738 -0.6242159707402826 down LSVYAALQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSVYAALQR 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 46871000.0 13064000.0 14164000.0 19643000.0 False True 19819043.106331404 11636323.536162892 15760552.440167248 1.0 0.5871284235940506 0.7952226732446216 24.24038397289758 -10.2553056056683 4.74093658347581 1.0000910247534829 0.6911755484186121 0.7459724345818103 0.08495412167776749 8.175992436382381e-05 1.2842722901749553e-05 0.08228063647784914 0.02741882487044273 5.555132144649491e-11 10.2553056056683 -0.3089154763348708 LSVYAALQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LSVYAALQR 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 7973200.0 1316100.0 2393900.0 4263200.0 False True 1802697.7362651778 2288129.5824313224 3256319.9633600605 1.0 1.2692807764721892 1.8063593789752528 20.781726085368874 -6.96009927901132 0.4340403181853828 0.9795584368395346 2.116815505784431 0.9997738431157716 0.005040780877106588 0.07966578877749851 0.021001141287264657 0.007032240716645672 0.04455386841294984 1.0962275716604126e-07 6.96009927901132 1.1372570689448964 LSVYAALQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSVYAALQR 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 8072000.0 2732100.0 2727700.0 2612200.0 False True 2271862.202551916 2713005.338693941 3158398.9425518336 1.0 1.1941768896223117 1.3902246971687355 21.11544390164746 -6.97100606782385 0.23290697889592046 0.9231118515526889 1.666911085736252 0.9999892000784746 0.0005235096382031853 0.07597757757596954 0.007852333373251917 0.004931203825588602 0.01936321931653264 1.0690399428335319e-07 6.97100606782385 0.743799234183563 LSVYAALQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSVYAALQR 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 44211000.0 13064000.0 15984000.0 15163000.0 False True 16911605.529939126 15094476.348934753 12403489.585518455 1.0 0.8925513501490172 0.7334306351670858 24.01151029499003 -6.965469922534414 0.3499041613705642 1.0153940738962788 0.6052194933566136 0.9999224928671266 0.0009640520659998153 0.07780196925577561 0.014300412481087182 0.0021847108858442555 0.013677718453314275 1.0827546997077848e-07 6.965469922534414 -0.41017458053966516 LSWLDGSGLGFSLEYPTISLHALSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSWLDGSGLGFSLEYPTISLHALSR 25 0 P54105;E9PMI6;E9PJF4;J3KN38 P54105 CLNS1A Methylosome subunit pICln 0 3841375400.0 1676975400.0 1147600000.0 1016800000.0 False True 2544094285.123801 942801813.760276 815829034.3207283 1.0 0.3705844627194692 0.3206756286868622 31.244504992438696 -13.999999999999998 0.3593092190926109 9.200067489712096 0.3146066613042065 0.9997720373327731 0.004667603366333588 21.62212953480344 0.1936650674134471 135.91636757715176 0.014434263071289644 1.0000000000000041e-14 13.999999999999998 -8.885460828407888 LSWLDGSGLGFSLEYPTISLHALSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSWLDGSGLGFSLEYPTISLHALSR 25 0 P54105;E9PMI6;E9PJF4;J3KN38 P54105 CLNS1A Methylosome subunit pICln 0 3123535400.0 1676975400.0 177560000.0 1269000000.0 False True 2170877713.4271183 167678629.9122157 1038055021.0395645 1.0 0.07724001627318981 0.4781729595449249 31.015631314531145 -10.702912516098223 6.582332723974274 1.0080017512369661 0.2777064898469973 0.8122896427438946 0.1636801886813308 0.019151220390915165 0.0008643719106620457 0.15791209107675575 0.05282755373890678 1.9819262230871253e-11 10.702912516098223 -0.7302952613899688 LSWTTHAK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSWTTHAKER 10 1 Q8IWA4;Q8IWA4-3;H7C5H5 Q8IWA4 MFN1 Mitofusin-1 1 8030320.0 285020.0 3976400.0 3768900.0 True False 432396.1777531057 3266780.352244994 3023975.263032451 1.0 7.555062973082745 6.993529125872878 18.721994244593066 -9.34435232564151 8.969231361233089 1.0000000060685206 7.274296049478838 0.994028520120525 0.22924523316326675 0.0 0.0 0.22196574255868376 0.07398858085289457 4.525303113123638e-10 9.34435232564151 6.274296043410317 LSWTTHAK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSWTTHAKER 10 1 Q8IWA4;Q8IWA4-3;H7C5H5 Q8IWA4 MFN1 Mitofusin-1 1 5193320.0 285020.0 2111900.0 2796400.0 True False 368964.0085841432 1994370.908490697 2287483.8934870264 1.0 5.405326433176681 6.199748052025405 18.493120566685516 -9.564364247125747 0.4929211658199805 1.6731282988436584e-18 6.197022418103318 0.998507098284717 0.0883672418865734 0.8774172387718296 0.21318387686908358 1.7567543324084118 0.16244878301287624 2.726689921406841e-10 9.564364247125747 6.197022418103318 LSYEK(ub)QDTLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSYEKQDTLLK 11 1 P46977;A0A0C4DH80;E9PN73;E9PI32 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 47030200.0 3791700.0 6971700.0 36266800.0 True False 3671334.5589716495 9755536.166935217 26767437.099321384 1.0 2.657217970804537 7.2909283175813355 21.807873158721197 -6.953021741401467 0.524623597560892 0.9239815925602228 9.232591092092182 0.9994175733970275 0.0642520953508562 0.08229460243659277 0.03111291123999176 0.07226513254568885 0.3829337215469419 1.11423875181364e-07 6.953021741401467 8.30860949953196 LSYEK(ub)QDTLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSYEKQDTLLK 11 1 P46977;A0A0C4DH80;E9PN73;E9PI32 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 40778200.0 3791700.0 7756300.0 29230200.0 True False 3152966.5507910084 7714515.272394997 35342099.67482527 1.0 2.446748212555442 11.20915782184836 21.588278434155473 -6.935636038833804 0.6989790632078571 0.8904106527511233 13.296747352157675 0.9975346605899701 0.2239551461439908 0.08981502085109176 0.06410476118914403 0.21137232771519643 0.7697681748303715 1.1597488783571601e-07 6.935636038833804 12.406336699406552 LSYNTASNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSYNTASNK 9 0 P49207 P49207 RPL34 60S ribosomal protein L34 0 6961500.0 2521200.0 1186800.0 3253500.0 False True 2441165.8860351075 1660695.4290802414 2401310.747092164 1.0 0.6802878241828577 0.9836737277171789 21.21913890411083 -10.591794116562106 8.924058500636242 1.0000382389352458 0.831980776153732 0.2902495550588562 0.12385677646872106 9.425158845896232e-05 4.3112456206669734e-06 0.11995102699405533 0.039974602714857616 2.5597991082605624e-11 10.591794116562106 -0.1680574627815138 LSYNTASNK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSYNTASNKTR 11 1 P49207 P49207 RPL34 60S ribosomal protein L34 1 8681560.0 0.0 6823360.0 1858200.0 True False 0.0 9547963.231352339 1371481.6751949168 0.0 LSYNTASNK(ub)TR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LSYNTASNKTR 11 1 P49207 P49207 RPL34 60S ribosomal protein L34 1 26529000.0 2900300.0 6604000.0 17024700.0 True False 4399967.140331671 5425464.602712485 13659760.582808927 1.0 1.2330693456732298 3.1045142263901657 22.069061318833754 -6.930027389037449 0.7465695872862357 0.9715698073618118 3.488977318718795 0.9965435798778816 0.055379111357795774 0.09262366318711028 0.07761116036172568 0.05046118770801789 0.1693080777701645 1.174823461669203e-07 6.930027389037449 2.5174075113569834 up LSYNTASNK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LSYNTASNKTR 11 1 P49207 P49207 RPL34 60S ribosomal protein L34 1 21180230.0 0.0 7762270.0 13417960.0 True False 0.0 7720453.110820046 16223593.398362616 0.0 LSYNTASNK(ub)TR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LSYNTASNKTR 11 1 P49207 P49207 RPL34 60S ribosomal protein L34 1 13002780.0 2900300.0 9147030.0 955450.0 True False 3754495.5234600757 8637989.739614412 781567.903744879 1.0 2.3007058300215513 0.20816855390057837 21.840187640926203 -6.738593600715604 1.6916666217757597 1.7751852080223693 0.20727876136829534 0.5986271605442384 0.546525655865874 0.3203979510185031 1.7997473536331907 0.255626128730208 0.6282979443546991 1.8256032460654145e-07 6.738593600715604 -1.567906446654074 LSYNVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LSYNVR 6 0 A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247;Q13247-2 A0A590UJK4 SRSF6 Serine/arginine-rich splicing factor 6 0 2595630.0 1167600.0 277130.0 1150900.0 False True 1130535.1771119267 387789.45421385806 849444.7637400861 1.0 0.34301405393196854 0.7513651772517895 20.108574452218896 -10.928474459301539 10.23383344659881 1.0839336109214104 0.5471896155918883 0.6211363371629128 0.166708648004315 0.0771459674947003 0.0005391821340936767 0.03900521911453186 0.05380498478245551 1.1790318596341828e-11 10.928474459301539 -0.5367439953295221 LTAALILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTAALILK 8 0 Q68CP9-3;Q68CP9;F8WCU9;F8VWP4;F8W108 Q68CP9-3 ARID2 AT-rich interactive domain-containing protein 2 0 18935800.0 6127000.0 5695700.0 7113100.0 False True 9295106.943699664 4679257.834292788 5707192.667217516 1.0 0.5034108658066001 0.6139996776568473 23.14804003331321 -9.781233888088027 6.231502955430334 1.0000000112197722 0.5587052717313706 0.9550181016959969 0.045147693383725006 7.05916875739926e-09 1.3589137390803337e-09 0.043714067450859616 0.01457135538269337 1.654878493221558e-10 9.781233888088027 -0.4412947394884016 LTAALILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTAALILK 8 0 Q68CP9-3;Q68CP9;F8WCU9;F8VWP4;F8W108 Q68CP9-3 ARID2 AT-rich interactive domain-containing protein 2 0 21304100.0 6127000.0 7112500.0 8064600.0 False True 7931522.281226036 6716683.122610018 6596925.549783829 1.0 0.8468340483022344 0.831735109084771 22.91916635540566 -13.999999999999993 0.3275573281206464 2.642996076851835 0.8289840137927653 0.9997097438190631 0.0012950019813661787 18.618954864887833 0.18288583743257675 21.047865381654084 0.004883054470276889 1.0000000000000164e-14 13.999999999999993 -1.8140120630590695 LTAALVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTAALVLR 8 0 B4DG22;B1AXG1;B7ZB17;P51812;A0A2R8Y603 B4DG22 RPS6KA3 Ribosomal protein S6 kinase alpha-3 0 4332720.0 970920.0 1675400.0 1686400.0 False True 1272885.5224026544 1425436.8506580512 1511907.505091067 1.0 1.1198468562730184 1.1877796380598649 20.27967124489615 -13.999975924838285 0.06558365045291183 0.27909802011223295 1.4584336024530402 0.9999385978566007 0.0006082863712567322 12.406093265024383 0.06760255129609169 1.408553964151592 0.2511325746106636 1.00005543664503e-14 13.999975924838285 1.1793355823408072 LTAALVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTAALVLR 8 0 B4DG22;B1AXG1;B7ZB17;P51812;A0A2R8Y603 B4DG22 RPS6KA3 Ribosomal protein S6 kinase alpha-3 0 18395800.0 5486000.0 7316000.0 5593800.0 False True 8322663.080322576 6010402.639831104 4488182.978150367 1.0 0.722173009026595 0.5392724582065397 22.988613804184162 -8.440780589490512 0.1076367888884395 1.5301401073515164 1.1423223240732981e-11 0.999974274463972 0.0009607139116410039 0.12640998406302265 0.025160341303914233 0.17549225446476446 0.1622696019380683 3.6242605393459065e-09 8.440780589490512 -1.530140107340093 LTAALVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTAALVLR 8 0 B4DG22;B1AXG1;B7ZB17;P51812;A0A2R8Y603 B4DG22 RPS6KA3 Ribosomal protein S6 kinase alpha-3 0 5320820.0 970920.0 1878400.0 2471500.0 False True 1329895.362126425 1795406.07696186 1887782.6021402688 1.0 1.3500355953502317 1.4194970942088367 20.34288130641904 -12.370675438601047 0.2545837341636227 3.4332054096466987e-07 1.4481379100730054 0.9994265416723882 0.004396279431072599 6.274362145585261 0.15075317264219706 3.2726139689568834 0.031232383937302145 4.2591659457604185e-13 12.370675438601047 1.4481375667524645 LTAALVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTAALVLR 8 0 B4DG22;B1AXG1;B7ZB17;P51812;A0A2R8Y603 B4DG22 RPS6KA3 Ribosomal protein S6 kinase alpha-3 0 22145600.0 5486000.0 12612000.0 4047600.0 False True 7101735.145227043 11910131.113160979 3310978.331883173 1.0 1.6770734010216612 0.46622103812311644 22.75974012627661 -6.754941738091403 1.63133936251402 1.3957428831218788 0.4628434974123402 0.6700498407190322 0.2846106063405915 0.29149884695260847 1.527653889966556 0.13773056489575075 0.3326849624267771 1.7581594605085957e-07 6.754941738091403 -0.9328993857095386 LTAASVGVQGSGWGWLGFNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTAASVGVQGSGWGWLGFNK 20 0 P04179-4;P04179;F5H3C5;F5H4R2;F5GYZ5;P04179-2 P04179-4 SOD2 Superoxide dismutase [Mn], mitochondrial 0 32861900.0 8529800.0 9673100.0 14659000.0 False True 12940330.21190948 7946859.728724742 11761642.224732056 1.0 0.6141156831848806 0.9089136082406435 23.62537109676652 -9.775478322593885 5.884635726181777 1.0000000148455983 0.7615146457117846 0.46598204170097246 0.1203507489397793 2.33583592709814e-08 5.016304993973252e-09 0.11652911853098903 0.038843037195105776 1.6769560373643125e-10 9.775478322593885 -0.23848536913381368 LTAASVGVQGSGWGWLGFNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTAASVGVQGSGWGWLGFNK 20 0 P04179-4;P04179;F5H3C5;F5H4R2;F5GYZ5;P04179-2 P04179-4 SOD2 Superoxide dismutase [Mn], mitochondrial 0 28426900.0 8529800.0 10736000.0 9161100.0 False True 11041994.247494997 10138532.16229752 7493873.800823918 1.0 0.9181794461265511 0.6786703228471603 23.39649741885897 -6.9520011331016915 0.536423531799842 1.0036115577287708 0.5822451986007121 0.9993491185421362 0.0034785049253775995 0.08269197397638528 0.03271259382665436 0.003845034545226342 0.01982382475926548 1.1168603338177154e-07 6.9520011331016915 -0.42136635912805864 LTADELWK(ub)GALAETGAGAKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTADELWKGALAETGAGAKK 20 2 P82675;P82675-2 P82675 MRPS5 28S ribosomal protein S5, mitochondrial 2 150484000.0 13873000.0 17485000.0 119126000.0 True False 18187637.346323103 14876306.15599617 106799984.25728078 1.0 0.8179350551545737 5.872119738459155 24.11645480697396 -6.898541543326524 0.9704255996730645 0.7813735978982032 6.387234320405732 0.9858271001412594 0.2786761115384326 0.11248743324616432 0.18352910258599392 0.21595217544597528 0.5578799358699293 1.2631602678502581e-07 6.898541543326524 5.605860722507528 up LTADPGGSSETSSQVLENHTK(ub)PK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTADPGGSSETSSQVLENHTKPK 23 1 Q01831;Q01831-2 Q01831 XPC DNA repair protein complementing XP-C cells 1 8093500.0 2837300.0 2553300.0 2702900.0 True False 3672940.7815444185 2411206.6104689124 2210999.9340960095 1.0 0.6564784879148078 0.601969937878039 21.80850420515391 -13.999999999999998 0.25910770467427297 3.503085676401085 0.581876492157328 0.9995605176506267 0.003693744978434684 14.377916673057003 0.1610789875061106 18.83399862246421 0.02394302956182601 1.0000000000000041e-14 13.999999999999998 -2.921209184243757 LTAEAIQTPLK(ub)SAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTAEAIQTPLKSAK 14 1 Q53HL2 Q53HL2 CDCA8 Borealin 1 5670580.0 2807700.0 2024200.0 838680.0 True False 2334726.9521997813 2013295.2328277586 1014044.1103818135 1.0 0.8623257768668968 0.4343309222632567 21.15482240502302 -6.950647279360332 0.5516898976690485 1.0058606075068977 0.2706310843258896 0.9992511171209205 0.006591264453811461 0.08322682207046483 0.03489444883388704 0.0071385687806432814 0.03551727610387272 1.1203474258358777e-07 6.950647279360332 -0.735229523181008 down LTAEFEEAQTSACR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTAEFEEAQTSACR 14 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5;A0A087WU26 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 11432700.0 1072600.0 5164500.0 5195600.0 False True 1406188.9870731765 4393976.731063324 4658009.151714386 1.0 3.1247412484781933 3.312505783030989 20.423359070129198 -10.29494212191908 0.513051251541548 2.823012419163904e-13 3.3038288058984038 0.9995228503673949 0.022906988159768937 1.629644602716283 0.24138074441307994 2.3333501493137994 0.037178603457043706 5.0705827902646685e-11 10.29494212191908 3.3038288058981213 LTAEFEEAQTSACR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTAEFEEAQTSACR 14 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5;A0A087WU26 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 9739900.0 1072600.0 3647300.0 5020000.0 False True 1469169.2059251072 3486150.225991794 3834379.390145314 1.0 2.3728718325515357 2.6098963786345357 20.48656913165209 -10.420917857174413 0.37085329367377146 2.928219368437718e-21 2.6442092469027862 0.999149669537457 0.020694371327254487 1.8774481149509583 0.1747502216331055 1.8773614382913524 0.0657027161950449 3.7938673571600845e-11 10.420917857174413 2.6442092469027862 LTAELIEQAAQYTNAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTAELIEQAAQYTNAVR 17 0 P09661;H0YKK0 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 0 3094590.0 777190.0 1242600.0 1074800.0 False True 1018903.6163186652 1057208.9236168626 963590.0062096057 1.0 1.0375946327844 0.9457126177362001 19.958586154845825 -6.7955979121220285 1.4737087466417411 1.020859749195111 0.9445763636640663 0.8190100929826547 0.016045677482353474 0.22710251809011694 0.9741224174324113 0.00856725155019394 0.019981020075836263 1.6010396516736825e-07 6.7955979121220285 -0.07628338553104475 LTAELIEQAAQYTNAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTAELIEQAAQYTNAVR 17 0 P09661;H0YKK0 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 0 14897800.0 6377200.0 3624200.0 4896400.0 False True 6174759.276702789 5071361.959953324 3613885.951148625 1.0 0.8213052092714683 0.5852675042383799 22.557951463579936 -6.967284113683091 0.31640972300981696 1.0337178933447122 0.3652815756569814 0.9999527809534066 0.0011671457414402665 0.07719420492591259 0.012170315177811272 0.003631406981048671 0.020829566661172687 1.0782411105032738e-07 6.967284113683091 -0.6684363176877308 LTAELIEQAAQYTNAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTAELIEQAAQYTNAVR 17 0 P09661;H0YKK0 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 0 6303890.0 777190.0 2054900.0 3471800.0 False True 1064538.145770028 1964107.7233544094 2651832.3439654396 1.0 1.8450327319493869 2.4910637110587057 20.021796216368717 -7.0785604764510675 0.13172369650315396 3.74273662782911e-13 4.28550637720833 0.9999991864709952 0.0005506412140480875 0.07483772358136093 0.00429723805248486 0.044673938756777255 0.09205904037026516 8.34525330718589e-08 7.0785604764510675 4.285506377207956 LTAFVNTLNGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTAFVNTLNGK 11 0 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 0 51787000.0 10966000.0 15931000.0 24890000.0 False True 14376532.194895055 13554156.898551615 22314621.561739016 1.0 0.9427973808151414 1.5521560595581378 23.777212385289758 -6.8839084621155715 1.0577243065226065 0.962319763698686 1.598719439184739 0.9767052405531065 0.04193646952284998 0.12422588479832918 0.2518232296606051 0.030425299630633493 0.07436641754933024 1.3064462237074928e-07 6.8839084621155715 0.636399675486053 LTAFVNTLNGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTAFVNTLNGK 11 0 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 0 25257400.0 7582900.0 3723500.0 13951000.0 False True 7342184.990169606 5210312.967795979 10296814.578971194 1.0 0.7096406553052023 1.402418298198359 22.807778033671486 -6.792848263023351 1.4848542347734766 0.8383167298293949 1.4103835296606262 0.8104415728046542 0.123673142111642 0.2311329933208635 1.0066302592245888 0.0655473124729601 0.15315539202295977 1.6112084726271916e-07 6.792848263023351 0.5720667998312313 LTAFVNTLNGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTAFVNTLNGK 11 0 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 0 33488700.0 9597400.0 17710000.0 6181300.0 False True 14559957.463924132 14549512.131138444 4959563.345639963 1.0 0.9992825986743732 0.34063034579108475 23.79550280500396 -6.907133534294398 0.9150228550566706 1.0222880157821252 0.2605271137179833 0.9897943024042526 0.031383972155173974 0.10634481059684305 0.14927127024612064 0.0253356724135221 0.06862483696462729 1.2384157472470685e-07 6.907133534294398 -0.7617609020641419 down LTAFVNTLNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTAFVNTLNGK 11 0 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 0 32239100.0 10966000.0 8729100.0 12544000.0 False True 15020426.545007184 8343419.498726454 9581365.551789416 1.0 0.5554715422845179 0.6378890454994621 23.84042244681265 -10.832405741875768 7.347792932795365 1.0236701786961655 0.5966802938919904 0.9696325391188352 0.03364680479180092 0.011904607330792391 0.0002715293105600948 0.02972626930422491 0.010859459550978069 1.4709376291702786e-11 10.832405741875768 -0.4269898848041751 LTAFVNTLNGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTAFVNTLNGK 11 0 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 0 16247800.0 7582900.0 4640700.0 4024200.0 False True 6305517.329428256 4615699.627993177 4865641.61420148 1.0 0.7320096650042351 0.7716482819725539 22.588183309105762 -10.25475461716776 4.909854435125148 1.0000544130335298 0.7518289734882945 0.9812256443448634 0.016182397614529474 9.64080140946394e-06 1.4633306769174374e-06 0.015671968605400904 0.005222846371775382 5.562184401824714e-11 10.25475461716776 -0.24822543954523535 LTAFVNTLNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTAFVNTLNGK 11 0 P55036;P55036-2;A6PVX3;A2A3N6;Q5VWC4 P55036;Q5VWC4 PSMD4;PIPSL 26S proteasome non-ATPase regulatory subunit 4;Putative PIP5K1A and PSMD4-like protein 0 24596700.0 9597400.0 9291000.0 5708300.0 False True 12424023.493037175 8773947.682554616 4669447.972104133 1.0 0.7062082333852491 0.3758402400575822 23.56662912709641 -7.000432743836875 0.27137053794962596 1.0821873525863186 2.4057002312822524e-14 0.9999791509616137 0.0011641427475088588 0.073413267634597 0.009542342000370749 0.006433263114350397 0.029671210808216605 9.990040667631625e-08 7.000432743836875 -1.0821873525862946 down LTAGTGHK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTAGTGHKLR 10 1 Q12769;G3V198;E9PR16;Q12769-3 Q12769 NUP160 Nuclear pore complex protein Nup160 1 4658840.0 744540.0 1002300.0 2912000.0 True False 720904.9852405918 1402523.61692545 2149259.8418725585 1.0 1.945504117241439 2.9813358013542848 19.459449600261912 -6.9699541253285595 0.2592827778620965 0.7066310519278584 4.250911566231561 0.9999820216830465 0.0034308896449474578 0.07631762113237125 0.009083551768683439 0.02172381583755641 0.09783780282588242 1.0716324961584464e-07 6.9699541253285595 3.5442805143037024 LTAGTGHK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTAGTGHKLR 10 1 Q12769;G3V198;E9PR16;Q12769-3 Q12769 NUP160 Nuclear pore complex protein Nup160 1 3755240.0 744540.0 1204000.0 1806700.0 True False 619117.9987145442 1197513.8130247127 2184472.6167630358 1.0 1.9342254877278227 3.528362317520391 19.23985487569619 -6.963027297016621 0.3904385278108883 0.9025709829012515 4.61733536716144 0.9998665172257788 0.0120601299845453 0.0786370005890944 0.01726168854017309 0.020577103351397247 0.13407092397516499 1.0888616521950663e-07 6.963027297016621 3.7147643842601883 LTAGTGHK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTAGTGHKLR 10 1 Q12769;G3V198;E9PR16;Q12769-3 Q12769 NUP160 Nuclear pore complex protein Nup160 1 2239200.0 528170.0 614730.0 1096300.0 True False 683726.4767871976 580519.7351089005 896784.6489879232 1.0 0.849052588743877 1.3116131661331547 19.38305976810985 -6.8188124416311595 1.3768578114489096 0.9185359919268803 1.3214667142360084 0.8816354093036755 0.06626213845874283 0.19504886503381283 0.7268578176919176 0.037819546799062284 0.08720302769585495 1.517705676136095e-07 6.8188124416311595 0.4029307223091281 LTAILLQIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTAILLQIK 9 0 C9J5J4;H7C4T7;H0Y322;Q5TKA1-3;Q5TKA1;Q5TKA1-2 C9J5J4 LIN9 Protein lin-9 homolog 0 10179800.0 2734100.0 3908900.0 3536800.0 False True 4147829.589484132 3211326.254624905 2837749.929765488 1.0 0.7742184642219836 0.6841529692926513 21.983925192632405 -13.999999999960192 0.12678202376503195 2.0729680518507987 0.5527117967476506 0.999660416715681 0.0024481733728768927 11.942833790282956 0.11039636824219129 3.203130927160488 0.1167728013776468 1.0000000000916617e-14 13.999999999960192 -1.5202562551031482 LTAILLQIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTAILLQIK 9 0 C9J5J4;H7C4T7;H0Y322;Q5TKA1-3;Q5TKA1;Q5TKA1-2 C9J5J4 LIN9 Protein lin-9 homolog 0 9965100.0 2734100.0 3230000.0 4001000.0 False True 3539346.347168293 3050247.660601808 3272859.0537267947 1.0 0.8618110129409078 0.9247072009059794 21.755051514724855 -10.11925308109868 4.505623363132377 1.0000114819796166 0.8932591069198205 0.793396169304037 0.025677261225758086 2.9618796267281497e-06 5.789827793735562e-07 0.024864575238407464 0.00828730042356712 7.59883332897112e-11 10.11925308109868 -0.10675237505979618 LTAK(ub)EVFDNDGKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTAKEVFDNDGKPR 14 2 Q08209-2;Q08209-3;Q08209;Q08209-4 Q08209-2 PPP3CA Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform 1 8854500.0 4037000.0 2670900.0 2146600.0 True False 3908847.6447420814 3737404.298559499 1584341.0633803713 1.0 0.956139670367251 0.40532177443946177 21.898311923084503 -6.922748214753418 0.8040828541342465 1.0109922133011933 0.3106294553307581 0.9949108366435365 0.019303386925399922 0.0965817317871186 0.09743268325292553 0.01687860820810874 0.051967674539320115 1.194680528071826e-07 6.922748214753418 -0.7003627579704352 down LTALDYHNPAGFNCK(ub)DETEFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTALDYHNPAGFNCKDETEFR 21 1 Q9Y224;G3V4C6;G3V4E7 Q9Y224 C14orf166 UPF0568 protein C14orf166 1 10487800.0 3316500.0 4575400.0 2595900.0 True False 4542699.675042522 4373243.69917552 1982801.8842386906 1.0 0.9626970770711546 0.4364809531944527 22.11511849905323 -6.921193202754341 0.8158311965612101 1.011118929715649 0.34925124446368794 0.9945059051352517 0.01907193580303797 0.097474915204435 0.10201458625265973 0.016537068689257556 0.05011557905083883 1.1989658056299838e-07 6.921193202754341 -0.6618676852519612 down LTALDYHNPAGFNCK(ub)DETEFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTALDYHNPAGFNCKDETEFR 21 1 Q9Y224;G3V4C6;G3V4E7 Q9Y224 C14orf166 UPF0568 protein C14orf166 1 23997600.0 6935500.0 9825100.0 7237000.0 True False 8978141.469143655 9278324.548042983 5919940.257890726 1.0 1.03343487958293 0.6593725748515497 23.09798539839385 -6.885088159223096 1.0509674410182293 1.0225284098999512 0.6301291033824671 0.9775650504752695 0.025314240679230313 0.12322045778914392 0.24583493832022818 0.018460444994252933 0.045280725515884385 1.3029022701158594e-07 6.885088159223096 -0.3923993065174841 LTAPEDVFSK(ub)LQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTAPEDVFSKLQR 13 1 Q92621;U3KPX2 Q92621 NUP205 Nuclear pore complex protein Nup205 1 9481400.0 2571000.0 4247800.0 2662600.0 True False 3370605.8975994126 3614044.7977947155 2387099.693462686 1.0 1.0722240770920988 0.7082108576273507 21.684576521826614 -6.855148722273478 1.209962069144789 1.0387852671968154 0.6921454892193158 0.9474691715527905 0.03606655820461024 0.1518854440550203 0.4253165213120911 0.023289824674078453 0.054103352800131115 1.3958902625952222e-07 6.855148722273478 -0.34663977797749956 LTAPEDVFSK(ub)LQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTAPEDVFSKLQR 13 1 Q92621;U3KPX2 Q92621 NUP205 Nuclear pore complex protein Nup205 1 57623500.0 9347500.0 13266000.0 35010000.0 True False 14180840.893786939 10898578.652268903 28090258.154571917 1.0 0.7685424816411208 1.98085983510887 23.757439748081413 -6.857279493944333 1.199550550896456 0.8752304641291772 2.0365445397828847 0.9502263673244953 0.11723954155471981 0.14963576332077222 0.4107190947435106 0.07631259485392988 0.17760917633282836 1.389058403033094e-07 6.857279493944333 1.1613140756537077 LTAPEDVFSK(ub)LQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTAPEDVFSKLQR 13 1 Q92621;U3KPX2 Q92621 NUP205 Nuclear pore complex protein Nup205 1 9609900.0 2571000.0 2354800.0 4684100.0 True False 3521568.1786625427 2250757.1497177337 3577812.0520676626 1.0 0.6391349068165846 1.0159712578464066 21.747786583349505 -10.985260012705908 12.045817946465641 1.1145777351721111 0.8275530823323932 0.21827265561246678 0.15384279609256504 0.07161131065938517 8.762787844094021e-05 0.02253352912300965 0.049652548933373966 1.0345226111179145e-11 10.985260012705908 -0.2870246528397179 LTAPEDVFSK(ub)LQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTAPEDVFSKLQR 13 1 Q92621;U3KPX2 Q92621 NUP205 Nuclear pore complex protein Nup205 1 24417500.0 9347500.0 15070000.0 0.0 True False 12100523.016771724 14231341.252405325 0.0 1.0 1.176093069091329 0.0 23.528566070173863 -6.92512253402476 1.2493691431608007 1.0933962436356237 5.198508055402686e-19 0.9617693775730572 0.10126780168113621 0.11949098184145282 0.3728773823063386 0.0667941942968406 0.12979337606148317 1.1881669447551103e-07 6.92512253402476 -1.0933962436356237 down LTAQFVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTAQFVAR 8 0 Q15459 Q15459 SF3A1 Splicing factor 3A subunit 1 0 74941000.0 22780000.0 19323000.0 32838000.0 False True 29864800.601833776 16440083.720464082 29440238.764338497 1.0 0.5504836258459606 0.9857838716837369 24.831942753588432 -10.769944114834495 10.121137220399998 1.0010884546941359 0.7681337500362181 0.27446838818005415 0.17771058120177152 0.004382380267474195 9.961249007979626e-05 0.17276425855245386 0.05735584345327515 1.6984621971085503e-11 10.769944114834495 -0.2329547046579178 LTAQFVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTAQFVAR 8 0 Q15459 Q15459 SF3A1 Splicing factor 3A subunit 1 0 37811600.0 12916000.0 6603600.0 18292000.0 False True 12505988.64986095 9240451.917319061 13500776.451762673 1.0 0.7388821608615327 1.0795449148206913 23.57611577721797 -6.701901059014573 1.823859038483776 0.8381570692716475 1.078574636026231 0.42661824631879575 0.11018379503587192 0.39163060503991726 2.533967047325116 0.048169147693327044 0.12359908254914842 1.9865474411222072e-07 6.701901059014573 0.24041756675458348 LTAQFVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTAQFVAR 8 0 Q15459 Q15459 SF3A1 Splicing factor 3A subunit 1 0 80054000.0 21999000.0 28458000.0 29597000.0 False True 33374091.342328914 23379447.55663116 23747139.977174055 1.0 0.7005268642918412 0.7115441656101409 24.992225222097524 -10.114461404546006 5.262784999018112 1.0000064253299896 0.7060355149507355 0.9989476373443109 0.0044977944296149645 3.3909583227571365e-07 5.705690384968875e-08 0.004355065871416078 0.0014516569099180632 7.683137321620171e-11 10.114461404546006 -0.29397091037925416 LTAQFVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTAQFVAR 8 0 Q15459 Q15459 SF3A1 Splicing factor 3A subunit 1 0 54129000.0 22780000.0 15432000.0 15917000.0 False True 31202381.60635268 14750163.213200301 12157732.420904974 1.0 0.47272555663498544 0.38964116823793055 24.895152815111324 -13.999999999999998 0.2601008389840716 4.8619291545098084 0.35930368334895135 0.9995625397358479 0.005653042452103694 14.421570505050179 0.16138949176454265 29.275751682918038 0.03630407697195871 1.0000000000000041e-14 13.999999999999998 -4.502625471160857 LTAQFVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTAQFVAR 8 0 Q15459 Q15459 SF3A1 Splicing factor 3A subunit 1 0 33617400.0 12916000.0 12850000.0 7851400.0 False True 10740226.27581734 12780774.499474715 9493091.439228036 1.0 1.1899911762801374 0.8838818843698526 23.356521052652248 -6.738811641844393 1.6911009528934402 1.113191647093776 0.8837473802467799 0.5997288322360539 0.07982761880373203 0.3198916710334272 1.7958297624102486 0.037351472555453805 0.09177509278472418 1.8246869169339227e-07 6.738811641844393 -0.22944426684699604 LTAQFVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTAQFVAR 8 0 Q15459 Q15459 SF3A1 Splicing factor 3A subunit 1 0 94623000.0 21999000.0 44361000.0 28263000.0 False True 28478139.16512027 41892271.353546955 23119424.002869338 1.0 1.4710326089302974 0.8118305718228166 24.763351544189973 -6.714922470102322 1.7782190069700785 1.2881220056543268 0.8131811398472522 0.4882129698593388 0.19834536994024188 0.36525346310438905 2.254398511720447 0.0886760533957053 0.22389720778109912 1.9278690440867655e-07 6.714922470102322 -0.4749408658070746 LTATIWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTATIWK 7 0 O15226;O15226-2 O15226 NKRF NF-kappa-B-repressing factor 0 8963300.0 2297800.0 2544800.0 4120700.0 False True 3012438.051926855 2165125.7595527084 3694329.492545519 1.0 0.7187287247841735 1.2263586599507013 21.522500143248735 -6.756311177188629 1.6264560892789903 0.8358739530009923 1.2278762214484593 0.6756907540534765 0.1182487655728574 0.2891586183205679 1.506724056699181 0.05738901818681162 0.13841637193257653 1.7526242755974223e-07 6.756311177188629 0.392002268447467 LTATIWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTATIWK 7 0 O15226;O15226-2 O15226 NKRF NF-kappa-B-repressing factor 0 9482200.0 2297800.0 2940600.0 4243800.0 False True 3147358.7557101534 2810674.5687361793 3241501.843804523 1.0 0.893026434827889 1.0299117753651594 21.585710204771626 -6.698221688094757 1.8372716469636385 0.9334575223334622 1.0294902654596259 0.409092523971626 0.04516984784337014 0.399245170213509 2.618838577204318 0.019623207005391163 0.05057566677455057 2.0034490942919485e-07 6.698221688094757 0.09603274312616361 LTATPTPLGGMTGFHMQTEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTATPTPLGGMTGFHMQTEDR 21 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 7501200.0 1661900.0 3225700.0 2613600.0 False True 2178766.9938624953 2744438.13368012 2343169.743421495 1.0 1.2596290201802667 1.0754567835946276 21.055080486395976 -10.325362573476696 3.9889719648834365 0.999658955007528 1.167542901898237 0.5245847056250603 0.07518800077336876 53505155.94230416 88.82468462097513 167682.77376106405 0.025738852543048404 4.7275641050412924e-11 10.325362573476696 0.16788394689070907 LTATPTPLGGMTGFHMQTEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTATPTPLGGMTGFHMQTEDR 21 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 6133400.0 1661900.0 2116500.0 2355000.0 False True 2276349.3411588063 2022986.031670449 1798797.502747454 1.0 0.8886975277004806 0.7902115330996392 21.118290547918868 -6.972567317659972 0.18695316169863518 1.0694650626386626 0.6067619602000117 0.9999960948993889 0.0001692542407654362 0.0754780544526763 0.00594294516104081 0.0035690496006586694 0.010828361002039029 1.0652037393478627e-07 6.972567317659972 -0.46270310243865087 LTAVCMECFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTAVCMECFR 10 0 K7ES52;P04183;K7ERV3;K7ERJ1 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 0 6116700.0 1362400.0 2640200.0 2114100.0 False True 1786119.5935003688 2246292.451418994 1895353.211879164 1.0 1.2576383236560302 1.0611569453558949 20.76839725178414 -10.250803281694772 3.839919377948339 0.9997909474101719 1.1593976345503454 0.4673840288693215 0.08021318696131623 28334493.878287107 19.367042310579954 53024.09684298849 0.027459107419021484 5.6130216624589327e-11 10.250803281694772 0.15960668714017345 LTAVCMECFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTAVCMECFR 10 0 K7ES52;P04183;K7ERV3;K7ERJ1 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 0 5560600.0 1362400.0 1751300.0 2446900.0 False True 1866116.0974756347 1673921.7752253558 1868992.6154873653 1.0 0.8970083787872215 1.0015414464382049 20.831607313307032 -10.878928991285829 7.77386027874622 1.0058080948234756 0.9492749126126879 0.2389429238848063 0.0426754461654573 0.004739312889832873 7.381054853772783e-05 0.04558571395621605 0.013773441024232265 1.3215116884506572e-11 10.878928991285829 -0.056533182210787625 LTAYAMTIPFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTAYAMTIPFVR 12 0 H0YFD6;P40939;A0A2R8YG21;A0A2R8Y688 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 10712500.0 5583800.0 2664800.0 2463900.0 False True 5406545.325417589 3728868.5367484232 1818530.67458441 1.0 0.6896952327797999 0.3363572420331001 22.36627560442977 -7.132916506397743 0.2947223261306005 1.0722762761015179 6.48408720652023e-11 0.999951149245186 0.0018949444970748491 0.08020730954882314 0.013200401897332232 0.00797905641667469 0.03480818381889641 7.363486477428263e-08 7.132916506397743 -1.072276276036677 down LTAYAMTIPFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTAYAMTIPFVR 12 0 H0YFD6;P40939;A0A2R8YG21;A0A2R8Y688 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 16962500.0 3288100.0 6875400.0 6799000.0 False True 4503799.427561386 6571622.094092621 5193216.229800396 1.0 1.4591284980137031 1.1530744904002752 22.10271114911671 -10.470007854000258 5.566769990508621 0.9996568207068229 1.3061014942069897 0.5715045588662777 0.12494602539779834 0.0005327539293664963 5.07216218932112e-05 0.12111174605721035 0.04032615629503982 3.3883802836614356e-11 10.470007854000258 0.3064446735001668 LTAYAMTIPFVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTAYAMTIPFVR 12 0 H0YFD6;P40939;A0A2R8YG21;A0A2R8Y688 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 10814200.0 5583800.0 2696200.0 2534200.0 False True 4643177.1042821985 2681675.035446201 3064089.503183086 1.0 0.5775517442513682 0.6599122614464158 22.146680879864046 -10.252376985372308 7.063564567568495 1.0000019968564593 0.618732002848902 0.9661857824086479 0.03362354034659776 1.0573511796109662e-06 1.1194828202099061e-07 0.032556023678849855 0.010851950983575531 5.592719198300072e-11 10.252376985372308 -0.38126999400755734 LTCFELAPK(ub)SGNTGELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTCFELAPKSGNTGELR 17 1 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 21446300.0 6230800.0 7544000.0 7671500.0 True False 8168639.139153027 6418464.606281678 6877726.770224223 1.0 0.7857446628432141 0.8419672668925544 22.961664320800942 -10.256052634354322 5.82195319956275 1.000008682051914 0.8138559648678827 0.935961252895542 0.022952781988575425 2.5867080780150857e-06 3.3057024214322835e-07 0.022224971872226485 0.007407978532572702 5.545584991235326e-11 10.256052634354322 -0.18615271718403137 LTCFELAPK(ub)SGNTGELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTCFELAPKSGNTGELR 17 1 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 101949000.0 11529000.0 15372000.0 75048000.0 True False 17490335.88279965 12628746.498015825 60214729.90529303 1.0 0.7220413937524887 3.442742912931101 24.060054659119842 -6.881712941842985 1.070164771155917 0.823477608543217 3.6420322268741305 0.9750425352849441 0.19310038186670714 0.12612514324290472 0.26319009917313907 0.13877231508886487 0.33710623409335505 1.313067518146786e-07 6.881712941842985 2.8185546183309134 up LTCFELAPK(ub)SGNTGELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTCFELAPKSGNTGELR 17 1 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 22039900.0 6230800.0 7352600.0 8456500.0 True False 8534495.141038733 7027737.820203235 6459248.867084439 1.0 0.823450913506278 0.7568401833196526 23.024874382323834 -13.999999999999998 0.1352125965148103 1.8404742840523003 0.6694500520434128 0.9996226881869791 0.0019928672914694473 11.932128072225956 0.11483322249845374 2.6540884889580063 0.0779013611185951 1.0000000000000041e-14 13.999999999999998 -1.1710242320088875 LTCFELAPK(ub)SGNTGELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTCFELAPKSGNTGELR 17 1 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 14321800.0 5093100.0 1392100.0 7836600.0 True False 4235138.312586348 1384600.4809897863 9475196.827655513 1.0 0.32693158494373414 2.237281554535376 22.013977655675983 -6.811496502635859 1.4083129302582045 0.63383202993418 2.2718330553079595 0.8636811642866091 0.2921050293537857 0.20476665753239037 0.8001582324801059 0.16308129405027427 0.3769771793625603 1.5434888529570869e-07 6.811496502635859 1.6380010253737796 up LTCFELAPK(ub)SGNTGELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTCFELAPKSGNTGELR 17 1 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 116728900.0 11529000.0 9492900.0 95707000.0 True False 14924517.770565532 8964611.770070245 78289308.03674822 1.0 0.6006634122377108 5.245684265333661 23.83118098121229 -6.885986233902456 1.0458693501929481 0.7258763344880127 5.615093505177386 0.9782010837338125 0.31033281724056955 0.12245871644917457 0.24137323118631362 0.2271998970879863 0.5587997120581768 1.3002107909559737e-07 6.885986233902456 4.889217170689373 up LTCLFQIK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTCLFQIKR 9 1 Q15386;Q15386-2;Q15386-3 Q15386 UBE3C Ubiquitin-protein ligase E3C 1 11308880.0 522480.0 4562000.0 6224400.0 True False 792640.3584044734 3747875.456931314 4994144.611748559 1.0 4.728342958054156 6.300643865524845 19.596306900470523 -8.929647738972548 0.35732045035925697 4.056851065984671e-18 6.742740971792034 0.99794409620097 0.10078856141056942 0.4160529772476092 0.12475758532662053 1.0524120694904155 0.44119632866164865 1.1758509138469086e-09 8.929647738972548 6.742740971792034 LTCLFQIK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTCLFQIKR 9 1 Q15386;Q15386-2;Q15386-3 Q15386 UBE3C Ubiquitin-protein ligase E3C 1 7075680.0 522480.0 1752000.0 4801200.0 True False 676360.6596205299 1654499.659868223 3927430.8644721503 1.0 2.4461796178335904 5.806710973810369 19.367433222562973 -6.9570087101326425 0.47571970882555914 0.915997543174337 7.475993458931604 0.9996426685629687 0.03806236690988386 0.08078747509869932 0.02521460058100684 0.04697893512360321 0.27726631362536 1.1040564769203099e-07 6.9570087101326425 6.559995915757266 LTCLGVWLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTCLGVWLDK 10 0 Q9NWT1 Q9NWT1 PAK1IP1 p21-activated protein kinase-interacting protein 1 0 5314200.0 2071700.0 1886200.0 1356300.0 False True 2716018.7623713384 1604786.3123500121 1215963.086548277 1.0 0.590859803541594 0.4477005473580114 21.373062015138995 -13.999999999999988 0.14639772794687314 2.9682164154866575 0.2834819729421263 0.9995787044281639 0.004803549640496323 11.946009903706369 0.12030419818008724 6.696613177481374 0.14753099130651465 1.0000000000000286e-14 13.999999999999988 -2.6847344425445314 LTCLGVWLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTCLGVWLDK 10 0 Q9NWT1 Q9NWT1 PAK1IP1 p21-activated protein kinase-interacting protein 1 0 5287980.0 3353600.0 761980.0 1172400.0 False True 3247141.8036678275 1066242.5876732068 865313.2687539115 1.0 0.32836341993713564 0.26648459509113276 21.630738958254078 -13.999999999999998 0.3373944875701517 8.645884950657562 0.25645233610370854 0.9997299769534163 0.005458167771377028 19.467377396065842 0.1861651735321779 106.0208707665803 0.01929803215424907 1.0000000000000041e-14 13.999999999999998 -8.389432614553854 LTCLGVWLDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTCLGVWLDK 10 0 Q9NWT1 Q9NWT1 PAK1IP1 p21-activated protein kinase-interacting protein 1 0 26045000.0 6896100.0 9477100.0 9671800.0 False True 10461887.872441214 7785837.460079725 7760164.490699475 1.0 0.7442096068138179 0.7417556549369412 23.31863987702505 LTCLGVWLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTCLGVWLDK 10 0 Q9NWT1 Q9NWT1 PAK1IP1 p21-activated protein kinase-interacting protein 1 0 8244300.0 2071700.0 2656900.0 3515700.0 False True 2837663.475587397 2539509.372806628 2685364.068114319 1.0 0.8949297175842702 0.9463292921153901 21.436272076661886 -10.189952043945286 4.6295818955360355 1.0000141083264955 0.9206295048491415 0.760728131161827 0.02098378843525517 3.0561808450348723e-06 5.347655878702236e-07 0.020321076884340202 0.006772488595507656 6.457255279813392e-11 10.189952043945286 -0.07938460347735399 LTCLGVWLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTCLGVWLDK 10 0 Q9NWT1 Q9NWT1 PAK1IP1 p21-activated protein kinase-interacting protein 1 0 22447300.0 6896100.0 7087900.0 8463300.0 False True 8927137.392453553 6693452.134235158 6923066.240791289 1.0 0.7497870638681315 0.775507974890542 23.0897661991175 -9.911748357057357 5.427354237088161 1.00000029448728 0.762647519522134 0.9912695166156105 0.010500517958151474 3.741783915315166e-08 7.508992547204798e-09 0.01016709551882876 0.003389027597615495 1.2253259833730497e-10 9.911748357057357 -0.23735277496514584 LTDCVVMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 LTDCVVMR 8 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 93422080.0 9229680.0 51455000.0 32737400.0 False True 12100199.86034826 43778114.57001911 29350047.887315203 1.0 3.6179662381840294 2.4255837280418664 23.528527541062815 -8.973162699508283 11.362625891800564 0.9999999999999872 3.0217749831150345 0.7931021611281006 0.4867881213517751 0.0 0.0 0.4713305682668071 0.15711019059283113 1.0637444335629125e-09 8.973162699508283 2.0217749831150473 LTDCVVMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LTDCVVMR 8 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 48272370.0 22509300.0 4224970.0 21538100.0 False True 21794754.592467874 5912022.553927479 15896625.480850065 1.0 0.27125896411656025 0.7293785031350541 24.37747762334172 -10.429565206075074 5.4273291770546725 1.0004006412543067 0.5003187336281676 0.6133373783062165 0.1870265186324064 0.0009073687820832672 9.536802780473424e-05 0.1812282578420857 0.06036254933020315 3.719073778528022e-11 10.429565206075074 -0.5000819076261391 LTDCVVMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LTDCVVMR 8 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 74084880.0 9229680.0 33250500.0 31604700.0 False True 12642142.118723502 31781382.96530046 24140320.779228207 1.0 2.5139238798961925 1.9095118969969065 23.591737602585706 -10.181548440944079 6.306267491548184 0.9999916436143037 2.2117178884465516 0.8427400935887626 0.2467501587545158 2.899093749601051e-05 3.7626770354839317e-06 0.23891645864752578 0.07963827129418838 6.583419947797224e-11 10.181548440944079 1.211726244832248 LTDCVVMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTDCVVMR 8 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 22660600.0 17988000.0 1664300.0 3008300.0 False True 14957819.003515223 1655334.0855623153 3637321.621192366 1.0 0.11066680812044168 0.24317192368336335 23.834396495707285 -10.80513889370416 7.23112136093451 1.032090617347615 0.17691936590195714 0.9809330529596917 0.05409498690627938 0.02261760200365245 0.0006094885030310764 0.0423298376734124 0.017459081950110703 1.566250080400292e-11 10.80513889370416 -0.8551712514456579 LTDCVVMRDPASK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTDCVVMRDPASKR 14 2 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 56859300.0 5756200.0 9898100.0 41205000.0 True False 8732576.234588552 8131706.7207917245 33060813.689206906 1.0 0.9311921822775661 3.785917557553921 23.057975901594503 -6.901376942748575 0.952512772696793 0.8857534979881643 4.094101333527504 0.9872392516875897 0.15021985677353442 0.11039911731130364 0.17175478636499417 0.11796823914972991 0.30911204848483814 1.254940274551659e-07 6.901376942748575 3.2083478355393393 up LTDCVVMRDPASK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTDCVVMRDPASKR 14 2 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 66455100.0 5756200.0 13109900.0 47589000.0 True False 7451514.37166531 12380322.5404717 38928290.30437501 1.0 1.6614505351487188 5.224211933671017 22.829102223686952 -6.938159548337516 0.6764673506749959 0.9584502996473888 6.135102026467188 0.9979127877501528 0.0847551254584736 0.08861635098313779 0.058508670012797914 0.08139481880730629 0.30920863738341486 1.1530295873455856e-07 6.938159548337516 5.1766517268198 LTDDHVQFLIYQILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTDDHVQFLIYQILR 15 0 Q16539;B4E0K5;Q16539-5;Q16539-3;Q16539-4;Q16539-2;E7EX54;B5TY33 Q16539 MAPK14 Mitogen-activated protein kinase 14 0 8874300.0 2290400.0 3531300.0 3052600.0 False True 2964967.9505337253 3334780.0507378173 2497058.1223210194 1.0 1.1247271830164376 0.8421872222502516 21.499585079540324 -6.786696297101533 1.5093715202247373 1.0700113515896812 0.8394444819127517 0.7904722144826694 0.052919453494679705 0.24031955321460458 1.081607679985603 0.02760144315488453 0.06478440188366279 1.6341943433996684e-07 6.786696297101533 -0.23056686967692952 LTDFGFCAQITPEQSK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTDFGFCAQITPEQSKR 17 1 Q13177;H7C1X3;A0A087X294;O75914-2;O75914;O75914-4;O75914-3;H0YCG5;E9PM17;B3KNX7;Q13153;Q13153-2 Q13177 PAK2;PAK3;PAK1 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34;Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase PAK 3;Serine/threonine-protein kinase PAK 1 1 65852400.0 6716400.0 15139000.0 43997000.0 True False 10189269.834611472 12437327.168453127 35300973.66542983 1.0 1.2206298753817797 3.4645243710709814 23.28054733556533 -6.9259218202491 0.7795428958173087 0.9602306159851287 3.880729581424399 0.9956741996555306 0.07323147318265044 0.09481122155162289 0.08846499212584634 0.06516458558918387 0.2077718773944659 1.1859822241695488e-07 6.9259218202491 2.92049896543927 up LTDFGFCAQITPEQSK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTDFGFCAQITPEQSKR 17 1 Q13177;H7C1X3;A0A087X294;O75914-2;O75914;O75914-4;O75914-3;H0YCG5;E9PM17;B3KNX7;Q13153;Q13153-2 Q13177 PAK2;PAK3;PAK1 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34;Non-specific serine/threonine protein kinase;Serine/threonine-protein kinase PAK 3;Serine/threonine-protein kinase PAK 1 1 55497400.0 6716400.0 12277000.0 36504000.0 True False 8694512.200036984 11593774.157649646 29860646.56267004 1.0 1.333458840577661 3.4344245974539 23.05167365765778 -6.934810445717675 0.7061994940165752 0.973029475056631 3.9237995930169802 0.9974019500161779 0.05492820955572685 0.09021599436661146 0.06600236024606769 0.05156053204532012 0.18533172479039012 1.1619556559975428e-07 6.934810445717675 2.9507701179603494 up LTDFGLSK(ub)VTLNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTDFGLSKVTLNR 13 1 Q96GX5-2;Q96GX5-3;Q96GX5 Q96GX5-2 MASTL Serine/threonine-protein kinase greatwall 1 4297860.0 571300.0 759160.0 2967400.0 True False 475061.2628812676 755070.2543985384 3587869.6202925947 1.0 1.5894165940177987 7.552435655418433 18.857754046734854 -6.926006321704622 0.7788694623829558 0.8946518982662162 8.660787482738625 0.9956935805331858 0.19422656249138406 0.09476500005875303 0.08823045944251327 0.17291372196118118 0.5518708289106873 1.1857514879312343e-07 6.926006321704622 7.7661355844724085 up LTDK(ub)TVIGCSGFHGDCLTLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTDKTVIGCSGFHGDCLTLTK 21 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 15045200.0 2548900.0 5944200.0 6552100.0 True False 3341632.5835827156 5057348.530310118 5874151.5441812 1.0 1.513436442760534 1.7578687654174283 21.672121685433332 -10.713705888379474 0.14772283879494463 2.1715095702670733e-16 2.104212756945822 0.9996816574403956 0.005635060027196266 2.69549711880145 0.08167191310492494 1.179889822441229 0.23152207632980668 1.9332771219911064e-11 10.713705888379474 2.104212756945822 LTDK(ub)TVIGCSGFHGDCLTLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTDKTVIGCSGFHGDCLTLTK 21 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 306495100.0 14131100.0 59278000.0 233086000.0 True False 21437911.821791142 48699377.758872 187016449.93477696 1.0 2.271647451659457 8.72363182988182 24.35366104990161 -6.939479288054612 0.6643906602961148 0.92688891711194 10.437191600825757 0.9980948913764831 0.1475861572062827 0.08800500953898298 0.055697606423974574 0.14310339214036147 0.5565956463490574 1.1495310644177779e-07 6.939479288054612 9.510302683713817 LTDK(ub)TVIGCSGFHGDCLTLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTDKTVIGCSGFHGDCLTLTK 21 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 17653200.0 2548900.0 6055800.0 9048500.0 True False 3491297.211432507 5788234.732147379 6911430.659707148 1.0 1.6579037479803733 1.9796168132220784 21.735331746956223 -10.119016515164503 0.162435550347156 9.894576838407181e-16 2.3936039802368434 0.9996476168759487 0.007653320472153929 1.724781037306939 0.07774060267066314 0.9865518900168314 0.2571141962971991 7.602973641279965e-11 10.119016515164503 2.3936039802368425 LTDK(ub)TVIGCSGFHGDCLTLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTDKTVIGCSGFHGDCLTLTK 21 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 204596100.0 14131100.0 30929000.0 159536000.0 True False 18292987.515624817 29207773.961223934 130502084.97759497 1.0 1.5966650573765675 7.133995191661701 24.12478737199406 -6.927442946293949 0.7674865960023446 0.9073327870410852 8.200152759911804 0.9960115783268879 0.17441360252095048 0.09398692890748915 0.08434362079555707 0.15654739868089523 0.5082570717518643 1.181835561281916e-07 6.927442946293949 7.292819972870719 up LTDLK(ub)SLCSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTDLKSLCSR 10 1 Q8IUF8-4;Q8IUF8;Q8IUF8-2;D6RCB6 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 1 6351900.0 1833400.0 2716700.0 1801800.0 True False 1524553.3333914152 2702064.5978772724 2178548.0494180787 1.0 1.7723647567425191 1.4289746391304214 20.53995519030052 -10.219487844920259 4.511337070509751 0.9998249916515308 1.6006696979413422 0.803140299274412 0.14018842854263597 16103218.469117442 36478548.01630303 18402.199154840262 0.04799022515537298 6.032705920912594e-11 10.219487844920259 0.6008447062898113 LTDNQTSTMIK(ub)ATAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTDNQTSTMIKATAR 15 1 Q9H9G7-2;Q9H9G7;Q5TA58;A0A6I8PTZ8;Q9UL18;Q9HCK5 Q9H9G7-2 AGO3;AGO1;AGO4 Protein argonaute-3;Protein argonaute;Protein argonaute-1;Protein argonaute-4 1 10117700.0 2815100.0 2818600.0 4484000.0 True False 2725736.1914078314 3944081.6788048237 3309505.8828834333 1.0 1.4469785048301838 1.2141695492453681 21.37821450792918 -10.048171731665958 4.24442252219351 0.9999705769201789 1.3305740270083042 0.728871966696462 0.09504385839658835 12186209.90165182 7212355.838940018 3114.3107916024987 0.032536040881441214 8.950107843402088e-11 10.048171731665958 0.3306034500881253 LTDNQTSTMIK(ub)ATAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTDNQTSTMIKATAR 15 1 Q9H9G7-2;Q9H9G7;Q5TA58;A0A6I8PTZ8;Q9UL18;Q9HCK5 Q9H9G7-2 AGO3;AGO1;AGO4 Protein argonaute-3;Protein argonaute;Protein argonaute-1;Protein argonaute-4 1 5582200.0 1701100.0 1677400.0 2203700.0 True False 2330042.6404989706 1603286.9215799747 1683231.4466261426 1.0 0.6880933823754557 0.7224037094298345 21.151924926209528 -9.87716325147831 6.62200574284612 1.0000000108150495 0.7052485461171084 0.9899397699405571 0.0140071323652508 2.250688925242466e-09 3.6622392664147325e-10 0.01356234820094885 0.00452078253155501 1.3268955833645047e-10 9.87716325147831 -0.2947514646979411 LTDQLPLIIVCDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTDQLPLIIVCDR 13 0 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 2986050.0 531450.0 1308900.0 1145700.0 False True 696736.0965691202 1113617.2220522389 1027153.9543304289 1.0 1.5983343299363013 1.4742367438523107 19.410252782945065 -10.02857602408059 4.379329720750736 0.9999707924114373 1.5362855369737107 0.9613903785169596 0.050662627657032194 35292991.04785412 76673351.64498927 15682.713147984245 0.01854062184859563 9.363193010611902e-11 10.02857602408059 0.5363147445622735 LTDSLFLWVGATPHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTDSLFLWVGATPHLR 16 0 D6REN3;E2QRC7;D6RB92;H7C465;Q5JS54-3;Q5JS54;Q5JS54-2 D6REN3 PSMG4 Proteasome assembly chaperone 4 0 19214200.0 4094200.0 9010200.0 6109800.0 False True 6211200.726113141 7402259.412986085 4902195.3519795295 1.0 1.1917598125376134 0.7892508337992864 22.56644076114497 -6.777144862571652 1.546847181118485 1.1089827521512303 0.7863354860194882 0.7571925388592615 0.08100130266512956 0.2550441377200935 1.2051322887788185 0.04125134899651901 0.09757671959595246 1.6705333009558956e-07 6.777144862571652 -0.3226472661317421 LTEDK(ub)ADVQSIIGLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTEDKADVQSIIGLQR 16 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 35746000.0 13672000.0 11999000.0 10075000.0 True False 17924124.399836324 10208795.971735658 9032535.64622421 1.0 0.5695561882972024 0.5039317650744877 24.095399308669098 -13.999999999999998 0.26480552538968444 4.231597141525292 0.48102798833708643 0.9995722862474073 0.00455024618766831 14.6350106101243 0.16286305559116013 25.381300199410685 0.02798197443057341 1.0000000000000041e-14 13.999999999999998 -3.7505691531882053 LTEDK(ub)ADVQSIIGLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTEDKADVQSIIGLQR 16 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 68777000.0 21554000.0 20998000.0 26225000.0 True False 20869780.06806308 29382610.903123453 19355885.766863972 1.0 1.4079022781887154 0.9274599781951793 24.314912061240832 -6.681715544074087 1.8954536086649028 1.2576770294374269 0.9292471175887878 0.33218121028592795 0.17281260910367757 0.4347012235101631 3.020898636078347 0.07311238048582765 0.1924301078008609 2.0810593013023402e-07 6.681715544074087 -0.3284299118486391 LTEDK(ub)ADVQSIIGLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTEDKADVQSIIGLQR 16 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 195204500.0 26993500.0 35034000.0 133177000.0 True False 40951112.98918837 28781908.978108626 106854507.57644725 1.0 0.7028358175688026 2.6093187651495144 25.28739932687543 -6.867082802782137 1.1494897183992492 0.8345794138830033 2.7149178562220007 0.9616799956449984 0.16394782287356474 0.13967863368226177 0.3467829761925428 0.1108790467556414 0.26124729848004685 1.3580544946184673e-07 6.867082802782137 1.8803384423389975 up LTEDK(ub)ADVQSIIGLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTEDKADVQSIIGLQR 16 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 39804000.0 13672000.0 13748000.0 12384000.0 True False 18726907.871907547 13140567.901443599 9459154.256485973 1.0 0.7016944810817336 0.5051103108525332 24.15860937019199 -8.400971904985349 0.11965618737152407 1.4884500951873307 5.526113576000356e-10 0.9999630462599494 0.001236784223647282 0.11339971262111184 0.027344472252408786 0.16349851230578738 0.15336106879656378 3.97217245083412e-09 8.400971904985349 -1.4884500946347194 LTEDK(ub)ADVQSIIGLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTEDKADVQSIIGLQR 16 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 55705000.0 21554000.0 22555000.0 11596000.0 True False 17923106.00410087 22433491.73818305 14020669.986153841 1.0 1.2516520146145533 0.7822678715924496 24.09531733667511 -6.761078162917554 1.6084797064823972 1.1459772693840633 0.7804648485087747 0.6953367992080772 0.10586208759874684 0.2811053599493806 1.4336441166260843 0.051923318307934674 0.1246440351262914 1.7334919813916082e-07 6.761078162917554 -0.36551242087528857 LTEDK(ub)ADVQSIIGLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTEDKADVQSIIGLQR 16 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 177742500.0 26993500.0 34672000.0 116077000.0 True False 34943617.87143386 32742472.72086246 94952177.05059858 1.0 0.9370086646817752 2.7172966863348527 25.05852564896788 -6.8986978080019785 0.969475507659194 0.9233143175426709 2.8992959254419666 0.9859068893258003 0.097914411336163 0.1123697425973656 0.1828803282617388 0.07593118222502575 0.1962978312750105 1.2627058484860947e-07 6.8986978080019785 1.9759816078992958 up LTEGCSFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTEGCSFR 8 0 P42677;C9J1C5;H0YMV8;Q71UM5 P42677;H0YMV8 RPS27;RPS27L 40S ribosomal protein S27;40S ribosomal protein S27-like 0 7305520.0 3874300.0 770420.0 2660800.0 False True 3751312.4671846046 1078052.723687224 1963856.6577110277 1.0 0.28738014578036813 0.5235118841446232 21.838964007232267 -10.18173316883707 5.310523638869201 1.0000266129477988 0.4054460149631906 0.894213853169896 0.09640037851218514 3.063397924098631e-05 4.7199902377758015e-06 0.0933434692487301 0.031113088378711184 6.580620274444035e-11 10.18173316883707 -0.5945805979846082 LTELAEVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTELAEVKR 9 1 H0YNN7;Q9UPX6 H0YNN7 KIAA1024 UPF0258 protein KIAA1024 1 10027000.0 3413000.0 2169400.0 4444600.0 True False 3304656.1831817483 3035652.7332715457 3280425.9248581026 1.0 0.9185986574702595 0.9926678428918083 21.656068750702858 -10.187385762169825 5.066223412983118 1.0000033897539604 0.9556332506240507 0.3235868453958045 0.03023861832454827 1.1578638984940668e-06 1.8569425640247617e-07 0.029280653241494047 0.00975947209858663 6.495524688980127e-11 10.187385762169825 -0.044370139129909725 LTELMFEHYNIPAFFLCK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LTELMFEHYNIPAFFLCK 18 0 O96019;O96019-2;H7C5S0 O96019 ACTL6A Actin-like protein 6A 0 153472000.0 102673100.0 19685600.0 31113300.0 False True 99413798.64091346 27546162.739047848 22963793.351007383 1.0 0.27708590875342837 0.2309920118227602 26.566942776051317 -13.70800072473711 0.3938606604671552 9.999999999999998 0.22784040463269872 0.9998231614365063 0.004682944244299514 20.380441443428005 0.20571392379590636 154.96866141387204 0.01200292027480192 1.9588414046497147e-14 13.70800072473711 -9.772159595367299 LTELMFEHYNIPAFFLCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTELMFEHYNIPAFFLCK 18 0 O96019;O96019-2;H7C5S0 O96019 ACTL6A Actin-like protein 6A 0 88369000.0 21032000.0 32284000.0 35053000.0 False True 31907081.645159375 26522667.963956688 28124759.185724318 1.0 0.8312470648026327 0.8814582135245556 24.92737332395393 -10.074315282423026 5.5004140623609725 1.0000011631838792 0.8563526391635292 0.9160562348953749 0.020498615628180148 2.923878403076771e-07 4.91997640934614e-08 0.0198478598280136 0.006615899745654294 8.427227487533164e-11 10.074315282423026 -0.14364852402035 LTELMFEHYNIPAFFLCK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LTELMFEHYNIPAFFLCK 18 0 O96019;O96019-2;H7C5S0 O96019 ACTL6A Actin-like protein 6A 0 208782000.0 102673100.0 14916200.0 91192700.0 False True 85377231.8395495 14835843.46996613 110260671.9425952 1.0 0.17376814813869015 1.2914528799646428 26.347348051485593 -6.70861478688812 1.79965530518589 0.49136543444754127 1.2887874602673823 0.45882617929498537 0.3482419044363316 0.377820974475595 2.384361738939303 0.1540241054812661 0.3920237304378043 1.956073696461288e-07 6.70861478688812 0.797422025819841 LTELMFEHYNIPAFFLCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTELMFEHYNIPAFFLCK 18 0 O96019;O96019-2;H7C5S0 O96019 ACTL6A Actin-like protein 6A 0 42909800.0 21032000.0 12593000.0 9284800.0 False True 27226338.602700528 11892188.479863346 7595061.670093096 1.0 0.43678985461099723 0.2789600827685202 24.69849964604638 -13.999999999999998 0.17846007490145704 3.9086371798474833 0.15157416549570513 0.9995000760775703 0.006919708999010082 12.185230050092134 0.13390351993126484 12.285396125332932 0.11940221084875435 1.0000000000000041e-14 13.999999999999998 -3.757063014351778 LTELSMQDEELMK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTELSMQDEELMKR 14 1 P62072 P62072 TIMM10 Mitochondrial import inner membrane translocase subunit Tim10 1 7054900.0 3098400.0 2320100.0 1636400.0 True False 4062032.4049482835 1973950.1236789674 1467081.0254571994 1.0 0.4859513482153275 0.3611692077271545 21.953770318133945 -13.999999999999998 0.1988542616478133 3.8451661675475237 0.27920898666907346 0.9994869174383093 0.006262411357715573 12.508484432985194 0.14140193461029202 13.83548377014039 0.0801389522859267 1.0000000000000041e-14 13.999999999999998 -3.56595718087845 LTELSMQDEELMK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTELSMQDEELMKR 14 1 P62072 P62072 TIMM10 Mitochondrial import inner membrane translocase subunit Tim10 1 40732000.0 11951000.0 10751000.0 18030000.0 True False 11571622.046646666 15043930.365724362 13307402.111594204 1.0 1.3000710103631439 1.150003176559897 23.464087771926867 -10.173781438847085 4.214904258017496 0.9999278571042728 1.2250370934815502 0.7498922534255719 0.06126493667745713 42957220.90002177 4.380279550350041 30892.830171177276 0.020972617365523655 6.70221817476626e-11 10.173781438847085 0.22510923637727742 LTELSMQDEELMK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTELSMQDEELMKR 14 1 P62072 P62072 TIMM10 Mitochondrial import inner membrane translocase subunit Tim10 1 50443000.0 12353000.0 20460000.0 17630000.0 True False 18740404.125268806 16808753.145290364 14145422.772496508 1.0 0.8969258631208554 0.7548088439258036 24.15964872837378 -6.9666209226503 0.3290715415680306 1.0175029092858592 0.6295860214758772 0.9999427411781446 0.000760616002068752 0.07741538545202512 0.012944743445102548 0.0020806263088431433 0.012405057607901728 1.0798889004849522e-07 6.9666209226503 -0.387916887809982 LTELSMQDEELMK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTELSMQDEELMKR 14 1 P62072 P62072 TIMM10 Mitochondrial import inner membrane translocase subunit Tim10 1 21853600.0 5981100.0 8005600.0 7866900.0 True False 8192474.303149958 7651886.121021003 6008900.243891272 1.0 0.934014052150142 0.7334658641017506 22.965867811883022 -6.951158651562952 0.545982875699911 1.0028418864380062 0.6552813746924974 0.9992890507354196 0.00302205792581076 0.08302393939796879 0.03406354149860198 0.0032972658420680396 0.016624926206466252 1.1190290177281878e-07 6.951158651562952 -0.34756051174550884 LTELSMQDEELMK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTELSMQDEELMKR 14 1 P62072 P62072 TIMM10 Mitochondrial import inner membrane translocase subunit Tim10 1 35636500.0 11951000.0 14772000.0 8913500.0 True False 9937786.01906884 14692420.303987557 10777271.638632499 1.0 1.4784399941592041 1.0844741090171226 23.244493047361143 -9.977695646646977 5.3746496226256015 0.9999990986687686 1.2814570515889323 0.40494879444280363 0.16083589911303459 1.7370956368380808e-06 3.305114889496034e-07 0.15572918858044482 0.051909563227699955 1.0526993465518381e-10 9.977695646646977 0.28145795292016373 LTELSMQDEELMK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTELSMQDEELMKR 14 1 P62072 P62072 TIMM10 Mitochondrial import inner membrane translocase subunit Tim10 1 40642000.0 12353000.0 15465000.0 12824000.0 True False 15991202.014033826 14604359.155172413 10490163.585351761 1.0 0.913274633286208 0.6559959392762112 23.93077505046623 -6.951702061839131 0.5398333878253013 1.0037919605723498 0.5536008391337116 0.9993281799535856 0.003786296325940338 0.08280937841553065 0.03318873224395266 0.00416544947308988 0.021305759008643853 1.1176297100820302e-07 6.951702061839131 -0.45019112143863815 LTEQK(ub)GEQQIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTEQKGEQQIQK 12 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 1 6291900.0 1634800.0 2515600.0 2141500.0 True False 2143238.6314257183 2140282.285732001 1919918.1227185244 1.0 0.9986206175782906 0.8958023127090439 21.031361060126255 -6.909822137687257 0.8969212511087679 1.0032014107797567 0.882564130509743 0.9908548090468289 0.0046665145486636285 0.10453640415841567 0.13939712869242282 0.0038171788294708046 0.010524524009542265 1.2307727220986707e-07 6.909822137687257 -0.12063728027001364 LTEQK(ub)GEQQIQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTEQKGEQQIQK 12 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 1 8851900.0 2284200.0 3949700.0 2618000.0 True False 1899413.5072175562 3928422.1821459304 3165411.695735663 1.0 2.0682290439750854 1.6665205779086318 20.857122587434322 -10.10548089641753 4.550917300527896 0.9999305990477543 1.8673748109697954 0.8614243935001897 0.16399679464780464 25578457.860676233 28398973.16072104 15437.862393591702 0.05614046935263775 7.843666205472864e-11 10.10548089641753 0.8674442119220411 LTESINR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTESINR 7 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 3114890.0 933110.0 626680.0 1555100.0 False True 903488.9338085902 876916.5920930265 1147772.6580000073 1.0 0.9705891896168003 1.2703782138887494 19.78514740509255 -6.882790976952987 1.0640824907736859 0.9810000006181585 1.292797279016404 0.9758690386337919 0.020959444410127218 0.12518780177610525 0.25757499436089787 0.015132755934527205 0.036869601532321154 1.3098121752116282e-07 6.882790976952987 0.31179727839824545 LTESPCALVASQYGWSGNMER ddPTM_RPMI8226_Bortezomib_1h_R1 2 LTESPCALVASQYGWSGNMER 21 0 P14625 P14625 HSP90B1 Endoplasmin 0 26251100.0 4583300.0 11943800.0 9724000.0 False True 6008750.684740337 10161831.596567748 8717853.759194454 1.0 1.6911721137597646 1.450859624003719 22.518633632092826 -10.280481428479948 5.2232838899691165 0.9999003680995208 1.5710158688818237 0.8827398779799243 0.09810716312030601 0.00011384655081219142 1.5682429718370272e-05 0.095008287398866 0.03166395074234215 5.2422601774698446e-11 10.280481428479948 0.5711155007823029 LTESPCALVASQYGWSGNMER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTESPCALVASQYGWSGNMER 21 0 P14625 P14625 HSP90B1 Endoplasmin 0 14723600.0 6524900.0 1582800.0 6615900.0 False True 6317770.621049688 2214820.294192958 4882997.3172543505 1.0 0.3505699125595935 0.7728987977159335 22.590984127510346 -10.034156133608164 5.833842512727283 1.0000010166147826 0.561734355137903 0.5894673322276267 0.17241504537882799 2.2798225291645595e-06 3.773735872930247e-07 0.16694053788133914 0.05564671661561425 9.243657945987949e-11 10.034156133608164 -0.43826666147687954 LTESPCALVASQYGWSGNMER ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LTESPCALVASQYGWSGNMER 21 0 P14625 P14625 HSP90B1 Endoplasmin 0 28084800.0 4583300.0 11068400.0 12433100.0 False True 6277869.869025301 10579361.489695825 9496657.847732225 1.0 1.6851833042755267 1.5127197673510668 22.581843693615717 -10.052921194344744 4.461996884065887 0.9999671800478276 1.598951535763278 0.9414572544422425 0.07040794430426671 24390782.406098373 0.06266161542926107 8922.738013701892 0.024102512048798624 8.852762345852238e-11 10.052921194344744 0.5989843557154504 LTESPCALVASQYGWSGNMER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTESPCALVASQYGWSGNMER 21 0 P14625 P14625 HSP90B1 Endoplasmin 0 9880000.0 6524900.0 1169000.0 2186100.0 False True 5425743.452081188 1162702.3649716685 2643203.402615641 1.0 0.21429364938470932 0.4871596723950835 22.371389402944622 -10.35660280494421 5.792250542676798 1.000121817537954 0.3507266608999327 0.8830285693162653 0.11139708741966431 0.00017527218313425797 1.946916903526698e-05 0.10787971446019883 0.03595325536603011 4.399437932758901e-11 10.35660280494421 -0.6493951566380214 LTETFDFVHNVMSIPHHIIVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTETFDFVHNVMSIPHHIIVK 21 0 E5RIK9;Q96E29-3;Q96E29-2;Q96E29 E5RIK9 MTERF3 Transcription termination factor 3, mitochondrial 0 36742200.0 22189300.0 5215300.0 9337600.0 False True 33662790.35512241 4284588.967675114 7492019.267184526 1.0 0.1272796735646466 0.22256085096179432 25.004651432817834 -10.361411984556488 5.7621200415781715 1.0001725341703198 0.17492026226321863 0.9900971213486061 0.038898377785777954 8.623415025567998e-05 9.556848650981811e-06 0.03767086856666753 0.012554397446565661 4.350989301714911e-11 10.361411984556488 -0.8252522719071012 LTETFDFVHNVMSIPHHIIVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTETFDFVHNVMSIPHHIIVK 21 0 E5RIK9;Q96E29-3;Q96E29-2;Q96E29 E5RIK9 MTERF3 Transcription termination factor 3, mitochondrial 0 35928000.0 22189300.0 6829800.0 6908900.0 False True 28724486.266494036 6449715.626123284 5651551.091300434 1.0 0.224537196811301 0.19675029307287362 24.775777754910283 LTETQGELK(ub)DLTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTETQGELKDLTQK 14 1 V9GY01;Q9Y448-2;Q9Y448;H0YM11;Q9Y448-3 V9GY01 KNSTRN Small kinetochore-associated protein 1 9422700.0 2463600.0 4297600.0 2661500.0 True False 3229803.4575363393 3656414.8319135928 2386113.5109107406 1.0 1.1320858621851462 0.738779787154864 21.623014944935356 -6.816129131600036 1.3884836423496074 1.0714848788215932 0.7308823606489189 0.8752552534239684 0.05772077113065329 0.19856311769457594 0.7532050143293961 0.03267554455304516 0.07540258454311824 1.527111924615553e-07 6.816129131600036 -0.3406025181726743 LTETQGELK(ub)DLTQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTETQGELKDLTQK 14 1 V9GY01;Q9Y448-2;Q9Y448;H0YM11;Q9Y448-3 V9GY01 KNSTRN Small kinetochore-associated protein 1 10512900.0 3251200.0 3891500.0 3370200.0 True False 3147992.435616905 5445396.243904403 2487443.5161672086 1.0 1.72979965971147 0.7901681999053946 21.586000643488795 -6.69939022848475 1.8327021804931876 1.4534593240094844 0.792971679394021 0.4146782069192182 0.30809504895696943 0.3968798674398866 2.5911134993424634 0.1341247551057506 0.3452371514363448 1.998065732230289e-07 6.69939022848475 -0.6604876446154634 LTETQGELK(ub)DLTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTETQGELKDLTQK 14 1 V9GY01;Q9Y448-2;Q9Y448;H0YM11;Q9Y448-3 V9GY01 KNSTRN Small kinetochore-associated protein 1 7428200.0 2463600.0 2560000.0 2404600.0 True False 3374459.4962866805 2446890.7352120765 1836683.0042915174 1.0 0.7251207898345443 0.5442895392025414 21.686225006458248 -8.455424980777519 0.10583837105236013 1.5377101079831588 1.6036298356948517e-06 0.9999754648204313 0.000928027338654447 0.1318958850497953 0.024967232989659565 0.17884798195051851 0.16439253691543348 3.5040881204165516e-09 8.455424980777519 -1.5377085043533232 LTETQGELK(ub)DLTQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTETQGELKDLTQK 14 1 V9GY01;Q9Y448-2;Q9Y448;H0YM11;Q9Y448-3 V9GY01 KNSTRN Small kinetochore-associated protein 1 8938600.0 3251200.0 4032900.0 1654500.0 True False 2703516.8525810903 4011173.9672320248 2000448.300456325 1.0 1.4836874286182065 0.7399429741103576 21.36640591892307 -6.731199345524792 1.7190551343822809 1.2906920538248965 0.7403032084088895 0.5647559664713766 0.2033114877168268 0.3339816245930905 1.9341368803599222 0.09370713302033351 0.23219524873070804 1.8569518998867477e-07 6.731199345524792 -0.550388845416007 LTEVSISSDAFFPFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTEVSISSDAFFPFR 15 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 9335100.0 4913400.0 1863200.0 2558500.0 False True 4757426.806459187 2607185.476459643 1888352.0966452444 1.0 0.5480242960164624 0.3969271989810579 22.18175002997047 -13.999999999999998 0.15307140730508212 3.19647554544557 0.23642062217910081 0.999556313360108 0.005396849255118854 11.970576939674704 0.12336717238967476 7.814313280899344 0.14512089313472062 1.0000000000000041e-14 13.999999999999998 -2.960054923266469 LTEVSISSDAFFPFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTEVSISSDAFFPFR 15 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 110692000.0 27624000.0 41865000.0 41203000.0 False True 41907627.58491267 34393863.65726205 33059208.990083523 1.0 0.8207065309906572 0.7888589952532961 25.32070951618927 -13.999999999999792 0.2430686246930391 2.204643509482752 0.7751819241237606 0.9995301566983366 0.0020145514765670842 13.733725652044269 0.15602750587721032 8.044870993605223 0.01528617276546472 1.0000000000004785e-14 13.999999999999792 -1.4294615853589914 LTEVSISSDAFFPFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTEVSISSDAFFPFR 15 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 9494100.0 4913400.0 2147500.0 2433200.0 False True 4085709.8005265547 2135930.9912546254 2941970.8701543263 1.0 0.5227808864396959 0.7200635908539499 21.962155305404746 -10.21294702689181 5.469017437473123 1.0000187822953124 0.6214222386467884 0.8307918358236391 0.08054032681532881 1.844577171676894e-05 2.654513148958252e-06 0.07798670136612727 0.025994278704471574 6.124250877738919e-11 10.21294702689181 -0.378596543648524 LTEVSISSDAFFPFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTEVSISSDAFFPFR 15 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 68278000.0 27624000.0 19485000.0 21169000.0 False True 35759812.550446935 18400642.62130841 17316459.21228253 1.0 0.5145620546905925 0.48424356777189276 25.09183583828172 -13.999999999999996 0.3944086547500631 8.89465093625181 0.4822261155827725 0.9998297098714963 0.003083704035719571 25.962893784587457 0.20634543427677168 175.03737886891335 0.007880069907588428 1.0000000000000082e-14 13.999999999999996 -8.412424820669038 LTFDSSFSPNTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTFDSSFSPNTGK 13 0 P21796;C9JI87 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 0 14735400.0 4348500.0 4163100.0 6223800.0 False True 5700925.610933904 3541981.7076366968 5579820.878905235 1.0 0.621299408089709 0.9787570053893705 22.442764745775513 -10.572682882710208 9.131348648417072 1.0000250603515066 0.800028207450396 0.2944229217629737 0.14593145301090682 7.44608392944639e-05 3.4844595851835593e-06 0.1413151895031872 0.047099173933257694 2.6749589227604516e-11 10.572682882710208 -0.19999685290111058 LTFDSSFSPNTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTFDSSFSPNTGK 13 0 P21796;C9JI87 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 0 12138400.0 4348500.0 3407500.0 4382400.0 False True 5956257.963793889 3256945.3829043536 3347367.378361118 1.0 0.5468106658076667 0.5619916730787435 22.505974807298404 -9.962197693227449 5.976052705460103 1.0000002798870136 0.554401169443109 0.9991302451923635 0.0061976202662783015 2.311284195288367e-08 4.0100671555838835e-09 0.006000823864138117 0.0020002733397344328 1.0909436198907658e-10 9.962197693227449 -0.44559911044390454 LTFDSSFSPNTGK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTFDSSFSPNTGKK 14 1 P21796;C9JI87 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 1 50303000.0 15599000.0 17476000.0 17228000.0 True False 15103818.283460885 24454257.936136033 12715469.971078476 1.0 1.6190778700584705 0.8418712230537281 23.84840997682538 -6.69455500338845 1.8507833675635723 1.386462109074312 0.8444399554043893 0.3916264789318966 0.2615900085265356 0.40692217227708577 2.7060055168879287 0.11293870666141143 0.2923630986336827 2.020435527663626e-07 6.69455500338845 -0.5420221536699228 LTFDSSFSPNTGK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTFDSSFSPNTGKK 14 1 P21796;C9JI87 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 1 99040500.0 41748000.0 49877200.0 7415300.0 True False 63334768.18762419 40976223.9676577 5949662.704758558 1.0 0.6469783523367278 0.09393991444214587 25.91649436167693 -7.485685683717926 0.5505407434487452 1.006876381451291 1.1586646029995372e-24 0.9957669774282124 0.02426083187684717 0.11464531711794254 0.08182685315072535 0.024639617037597025 0.06933495373169636 3.268242823992066e-08 7.485685683717926 -1.006876381451291 down LTFDSSFSPNTGK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTFDSSFSPNTGKK 14 1 P21796;C9JI87 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 1 45171600.0 15599000.0 19880000.0 9692600.0 True False 12971259.652870439 19772902.494128935 11719277.846481096 1.0 1.5243625540834305 0.9034803218889933 23.628815252259656 -6.682827545029883 1.8917038583726542 1.330924385623038 0.905782281612518 0.33714113026367065 0.22210130789398186 0.43229116712835775 2.9932653542209517 0.09412284786271569 0.24735952313490958 2.0757376131285965e-07 6.682827545029883 -0.42514210401052 LTFDSSFSPNTGK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTFDSSFSPNTGKK 14 1 P21796;C9JI87 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 1 50512600.0 41748000.0 4032700.0 4731900.0 True False 54043608.97610975 3808276.6999717937 3870742.753394106 1.0 0.0704667355145594 0.07162258085142292 25.687620683769378 LTFDSSFSPNTGKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTFDSSFSPNTGKK 14 1 P21796;C9JI87 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 1 57155000.0 4352000.0 32234000.0 20569000.0 True False 5633749.7907451885 30440149.564036738 16825653.055762637 1.0 5.403177403093429 2.986581527529477 22.425664060678674 -9.866015085507637 7.4425691165952355 0.9999999883951506 4.194879465311458 0.6997401994493482 0.9865711349410228 1.875580577298833e-07 3.0600692463094225e-08 0.9552433867517196 0.31841446462295836 1.3613973926008628e-10 9.866015085507637 3.1948794769163076 LTFDTTFSPNTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTFDTTFSPNTGK 13 0 A0A0A0MR02;P45880-2;P45880;P45880-1;Q5JSD2;Q5JSD1 A0A0A0MR02 VDAC2 Voltage-dependent anion-selective channel protein 2 0 8226300.0 3132500.0 3273000.0 1820800.0 False True 4106737.8351731533 2784681.1580540733 1632401.0823469 1.0 0.6780761932753524 0.39749337500090814 21.969561421202183 -7.30916715730982 0.21413578512536638 1.161850804183976 1.1101211083222693e-15 0.9999696178705031 0.0013568501462911636 0.1079173457427827 0.013659363882061444 0.018587203041450114 0.04791026382903132 4.907189650486934e-08 7.30916715730982 -1.1618508041839748 down LTFDTTFSPNTGKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTFDTTFSPNTGKK 14 1 A0A0A0MR02;P45880-2;P45880;P45880-1;Q5JSD2;Q5JSD1 A0A0A0MR02 VDAC2 Voltage-dependent anion-selective channel protein 2 1 9577400.0 4865700.0 4711700.0 0.0 True False 6378979.819505825 4008732.7260627495 0.0 1.0 0.6284285010284455 0.0 22.60489428374918 -7.583438764905786 0.6838258083521408 0.9958577016255515 8.334671852084307e-21 0.9870965895853442 0.046881375037434815 0.12104843103153755 0.14584865013217915 0.042228085241312704 0.07691560763597804 2.609523637338506e-08 7.583438764905786 -0.9958577016255515 down LTFDTTFSPNTGKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTFDTTFSPNTGKK 14 1 A0A0A0MR02;P45880-2;P45880;P45880-1;Q5JSD2;Q5JSD1 A0A0A0MR02 VDAC2 Voltage-dependent anion-selective channel protein 2 1 54591000.0 15347000.0 14887000.0 24357000.0 True False 19866994.03459705 14058525.363275276 19924275.923924875 1.0 0.7076322335826591 1.002883269065671 24.243870267073714 -11.002073386158964 10.123999541984823 1.1519099692920076 0.855257751324165 0.24267659236127492 0.12053573049362498 0.06346229267945416 1.2997012451868198e-05 0.01792097746349295 0.03890273973539624 9.952372300690456e-12 11.002073386158964 -0.2966522179678426 LTFIPGFIGSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTFIPGFIGSLK 12 0 Q96RT1-7;Q96RT1-6;Q96RT1-4;Q96RT1-5;Q96RT1-3;Q96RT1-9;Q96RT1-2;Q96RT1;Q96RT1-8;B4DIP2 Q96RT1-7 ERBB2IP Protein LAP2 0 3543390.0 854090.0 1335500.0 1353800.0 False True 1119720.2610193263 1136248.6057382277 1213721.762566584 1.0 1.014761137486121 1.0839508802508264 20.094706919063498 -6.94125552354153 0.647776745314499 0.9992370703901353 1.1033191810886365 0.998323759268755 0.001498265615062463 0.087198411318391 0.052035851501929645 0.001472717962772683 0.0059228518621519425 1.1448391603040595e-07 6.94125552354153 0.10408211069850115 LTFIPGFIGSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTFIPGFIGSLK 12 0 Q96RT1-7;Q96RT1-6;Q96RT1-4;Q96RT1-5;Q96RT1-3;Q96RT1-9;Q96RT1-2;Q96RT1;Q96RT1-8;B4DIP2 Q96RT1-7 ERBB2IP Protein LAP2 0 3096660.0 1202300.0 493160.0 1401200.0 False True 1164133.6446057458 690081.3597954247 1034183.6849010417 1.0 0.5927853412647762 0.8883719577156333 20.15082526102583 -9.860166706674832 6.443010290755408 1.0000000117502763 0.7405786494901743 0.5066659543666183 0.12067273085016955 2.0306193258736546e-08 3.78315507025843e-09 0.11684087445416114 0.038946956410323565 1.3798544970842688e-10 9.860166706674832 -0.25942136226010204 LTFIPGFIGSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTFIPGFIGSLK 12 0 Q96RT1-7;Q96RT1-6;Q96RT1-4;Q96RT1-5;Q96RT1-3;Q96RT1-9;Q96RT1-2;Q96RT1;Q96RT1-8;B4DIP2 Q96RT1-7 ERBB2IP Protein LAP2 0 4604990.0 854090.0 1627200.0 2123700.0 False True 1169870.1539143901 1555304.9235691733 1622125.7989744253 1.0 1.3294679912681906 1.3865861895414513 20.15791698058639 -12.435791153444391 0.2726774564959056 1.3860837398506981e-14 1.406245550128916 0.9994679562885738 0.003929966369849764 6.550159078605963 0.15792453503341752 3.648823540005712 0.023399476842073323 3.6661383207776584e-13 12.435791153444391 1.4062455501289022 LTFLVAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTFLVAQK 8 0 Q13085-3;Q13085-2;Q13085;Q13085-4;Q59FY4 Q13085-3 ACACA Acetyl-CoA carboxylase 1;Biotin carboxylase 0 4364300.0 1106700.0 1337000.0 1920600.0 False True 1450894.4172980448 1137524.8115851816 1721874.7356961009 1.0 0.7840162578498017 1.1867677724632053 20.46851110652157 -6.761039017725955 1.608596865506514 0.8747068831741203 1.1883134345052864 0.6951867553944444 0.0908571332174283 0.2811723580019036 1.434181204714848 0.04456032027149237 0.10697427592831081 1.733648236966696e-07 6.761039017725955 0.3136065513311661 LTFLYLANDVIQNSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTFLYLANDVIQNSK 15 0 Q9NQG5;E9PIQ9;Q96P16-3;Q96P16;A0A0C4DGQ6 Q9NQG5;Q96P16 RPRD1B;RPRD1A Regulation of nuclear pre-mRNA domain-containing protein 1B;Regulation of nuclear pre-mRNA domain-containing protein 1A 0 3819800.0 1252800.0 1664300.0 902700.0 False True 1642432.9321324588 1415992.927390589 809297.263309835 1.0 0.8621313538520744 0.4927429592263965 20.64740302939664 -6.953961745290726 0.5135206518974256 1.0066062392107766 0.33196510604339424 0.999476586960169 0.004899505837439174 0.08193298701361182 0.029673449589000516 0.005609573067598226 0.030494209110313097 1.1118296581762305e-07 6.953961745290726 -0.6746411331673824 down LTFLYLANDVIQNSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTFLYLANDVIQNSK 15 0 Q9NQG5;E9PIQ9;Q96P16-3;Q96P16;A0A0C4DGQ6 Q9NQG5;Q96P16 RPRD1B;RPRD1A Regulation of nuclear pre-mRNA domain-containing protein 1B;Regulation of nuclear pre-mRNA domain-containing protein 1A 0 7874000.0 1252800.0 1924500.0 4696700.0 False True 1715994.0156470016 1839469.2265295468 3587436.1915728063 1.0 1.071955502033607 2.0905878219046077 20.71061309091953 -6.92114779197814 0.8161697422346375 0.9784411144084305 2.2592674446683234 0.9944938665636055 0.036954374500103346 0.09750103165568295 0.10214940424847825 0.03203505992207797 0.09703876810490039 1.199091178658503e-07 6.92114779197814 1.280826330259893 up LTFPLPCVVLYATHQENK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTFPLPCVVLYATHQENKR 19 1 Q9UKG1 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 1 29014300.0 4772200.0 20034000.0 4208100.0 True False 7239776.294552566 16458776.173643544 3376367.1905242493 1.0 2.273381870380117 0.46636346941613843 22.787513688769973 -6.7173628644091075 1.7690056043902118 1.7768863201878973 0.46962460159820735 0.499981129304255 0.5360234249916846 0.3604519924185761 2.20304573418035 0.24073958278518315 0.606183028174933 1.917066312236943e-07 6.7173628644091075 -1.30726171858969 LTFPLPCVVLYATHQENKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTFPLPCVVLYATHQENKR 19 1 Q9UKG1 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 0 4038600.0 818120.0 2398100.0 822380.0 False True 1072563.242685351 2040312.8277205836 737288.0064259906 1.0 1.9022774103392739 0.6874074899117931 20.03263128671663 -6.707821373573294 1.8030684624719284 1.555930299852166 0.6904518300478817 0.45472385107366686 0.3803464604801259 0.3794614685770305 2.403433812351453 0.16795818066368257 0.4278081681751811 1.9596505170214465e-07 6.707821373573294 -0.8654784698042843 LTFPLPCVVLYATHQENKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTFPLPCVVLYATHQENKR 19 1 Q9UKG1 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 0 83740000.0 57702000.0 12081000.0 13957000.0 False True 87538152.5812564 9925051.160716182 11198392.832429573 1.0 0.11337971922018063 0.1279258529249264 26.383408601649958 -10.131019886224589 5.2241648056182575 1.0000251196672478 0.12065278607192903 0.9997948143799753 0.005938434222344849 66341744.1305947 1.9252530509462422 20252.792922724482 0.0020328839866945395 7.39571409511959e-11 10.131019886224589 -0.8793723335953187 LTFPLPCVVLYATHQENKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTFPLPCVVLYATHQENKR 19 1 Q9UKG1 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 0 80968700.0 57702000.0 14512000.0 8754700.0 False True 74696376.4764656 13704394.44292674 7161434.430807784 1.0 0.1834679952279151 0.09587392010995499 26.154534923742407 -13.999999999999998 0.3153001439308446 9.14248657808136 0.07755712193584137 0.9996835807465562 0.007242214060518487 17.655855621369508 0.17887095105612041 94.59278333934122 0.02971017007733374 1.0000000000000041e-14 13.999999999999998 -9.064929456145519 LTFSCLGGSDNFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTFSCLGGSDNFK 13 0 Q15185-4;Q15185;A0A087WYT3;Q15185-3;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 205601000.0 51252000.0 75038000.0 79311000.0 False True 67191868.32507394 63842622.89583306 71104658.52483252 1.0 0.9501540065378559 1.05823309125486 26.001783310356256 -6.781274807281591 1.5306359826823688 0.9718228902990238 1.0591278052370847 0.7719628769298765 0.02109134357656824 0.24859853889082104 1.1504417601152055 0.010851495401090665 0.025580692258088854 1.6547225780391208e-07 6.781274807281591 0.08730491493806092 LTFSCLGGSDNFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTFSCLGGSDNFK 13 0 Q15185-4;Q15185;A0A087WYT3;Q15185-3;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 64464000.0 33471000.0 10673000.0 20320000.0 False True 32408481.42609911 14934784.558959732 14997582.413066762 1.0 0.4608295082574431 0.4627672063952046 24.94986808565829 -9.919666681877148 5.613031366279573 1.0000004392252482 0.4617983573260146 0.9999902778485076 0.0007910619559982912 2163263.156675213 0.8257048500955628 12.985488027974279 0.00027080154796258013 1.2031875187501382e-10 9.919666681877148 -0.5382020818992336 LTFSCLGGSDNFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTFSCLGGSDNFK 13 0 Q15185-4;Q15185;A0A087WYT3;Q15185-3;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 256930000.0 20900000.0 222140000.0 13890000.0 False True 31706827.994666725 182497381.4122584 11144635.411796719 1.0 5.755775426130786 0.3514900769534976 24.91829021919149 -6.674327682255628 1.9219514372922504 4.024238440913372 0.37284165775777994 0.2983580155153719 2.018161151045429 0.4512766959962479 3.21772459315245 0.8441112007075818 2.2426696721458015 2.1167634001256688e-07 6.674327682255628 -3.651396783155592 LTFSCLGGSDNFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTFSCLGGSDNFK 13 0 Q15185-4;Q15185;A0A087WYT3;Q15185-3;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 189351000.0 51252000.0 61756000.0 76343000.0 False True 70201249.43322158 59027415.72021748 58312355.73343904 1.0 0.8408314125002415 0.8306455540924274 26.064993371879147 -13.999999999999998 0.390818841078837 3.529806571168593 0.8299152367586239 0.9998243691136056 0.0010276577507241367 25.462643814129024 0.20501152839619174 54.43268530235294 0.0026746247701416514 1.0000000000000041e-14 13.999999999999998 -2.699891334409969 LTFSCLGGSDNFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTFSCLGGSDNFK 13 0 Q15185-4;Q15185;A0A087WYT3;Q15185-3;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 65075800.0 33471000.0 6451800.0 25153000.0 False True 27832619.516714342 6417042.872817962 30412376.005668126 1.0 0.23055835146829537 1.0926882389709873 24.730273361092568 -6.671390383934186 1.9327553066307832 0.5094387249782889 1.0891982435209753 0.2850374596914623 0.3267411143983709 0.4579632682816347 3.2995603603613435 0.13604380814605985 0.3627761071056598 2.1311283971531613e-07 6.671390383934186 0.5797595185426864 LTFSCLGGSDNFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTFSCLGGSDNFK 13 0 Q15185-4;Q15185;A0A087WYT3;Q15185-3;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 66173000.0 20900000.0 28650000.0 16623000.0 False True 27055462.000591513 27055602.314625926 13597784.566383505 1.0 1.0000051861629422 0.5025892578025914 24.68941654128394 -6.90689062836893 0.9166540034244528 1.0169560463816927 0.4424061775406371 0.9896942029387226 0.023804109961531074 0.10651010205739211 0.15018832573960242 0.019193953584760552 0.0519088514174449 1.2391086012368454e-07 6.90689062836893 -0.5745498688410555 LTFSCLGGSDNFK(ub)HLNEIDLFHCIDPNDSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTFSCLGGSDNFKHLNEIDLFHCIDPNDSK 30 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 746080000.0 99694000.0 155226000.0 491160000.0 True False 151243086.60767025 127524707.51372644 394082010.7169241 1.0 0.8431771023328154 2.6056199959683863 27.172293956727238 -6.885194834036581 1.0503694178798229 0.8941090746146825 2.7436813554153794 0.9776410551638969 0.11909056115465884 0.12312940117252383 0.24530558747539358 0.08688723482295509 0.21318798096278235 1.3025822803524095e-07 6.885194834036581 1.849572280800697 up LTFSCLGGSDNFK(ub)HLNEIDLFHCIDPNDSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTFSCLGGSDNFKHLNEIDLFHCIDPNDSK 30 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 575650000.0 99694000.0 113650000.0 362306000.0 True False 129055848.26253462 107325277.59362082 296370025.5734913 1.0 0.8316188614350284 2.2964478523328458 26.943420278819687 -6.878294188447845 1.08930476723854 0.8978259071771951 2.3969077980594684 0.9722816381984158 0.10895983755086526 0.12915011679228747 0.28152826365655464 0.07716942119038524 0.18582760790949154 1.323444738048231e-07 6.878294188447845 1.4990818908822732 up LTGAVMHYGNMKFKQK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTGAVMHYGNMKFKQK 16 2 Q9Y623;P12882;P13535;Q9UKX3;P11055 Q9Y623 MYH4;MYH1;MYH8;MYH13;MYH3 Myosin-4;Myosin-1;Myosin-8;Myosin-13;Myosin-3 1 10059200.0 2739200.0 5032100.0 2287900.0 True False 3591117.7264505294 4281330.294972167 2051170.055086486 1.0 1.1921999280162408 0.5711787279983906 21.776001518506742 -6.823582395963311 1.3562690542123568 1.1032366076301696 0.5565468977701985 0.8924324872657274 0.08513991574329177 0.18886652933773249 0.6816429036529702 0.04931705471475024 0.11357590742810363 1.501127579232032e-07 6.823582395963311 -0.5466897098599711 LTGDVEELEIQEK(ub)PALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTGDVEELEIQEKPALK 17 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 8009600.0 2583800.0 0.0 5425800.0 True False 3387386.821554791 0.0 4864390.263948719 1.0 0.0 1.4360303443927291 21.691741313662455 -6.71945805231236 1.7613852784320452 0.3912601997660427 1.4337061441915608 0.5099198680020813 0.4208312360482375 0.35636435409338585 2.1604619819275 0.18973317707876303 0.4765835202203701 1.9078399897693224e-07 6.71945805231236 1.042445944425518 LTGDVEELEIQEK(ub)PALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTGDVEELEIQEKPALK 17 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 22035400.0 3214100.0 3374300.0 15447000.0 True False 3112070.1548093916 4721675.586742043 11400967.299933195 1.0 1.5172137361508922 3.6634673168643537 21.56944315241653 -6.944031432741077 0.620925583683799 0.9765242818050477 4.318042316066955 0.998645695705624 0.04243724311346138 0.08597463540448282 0.04658912259103215 0.042701510969581 0.1817017607066973 1.137544951252326e-07 6.944031432741077 3.3415180342619073 LTGDVEELEIQEK(ub)PALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTGDVEELEIQEKPALK 17 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 99415000.0 10407000.0 22336000.0 66672000.0 True False 15788179.853612278 18349966.28803545 53494249.97662433 1.0 1.1622597701683164 3.3882468069544474 23.91234152334342 -6.921553557995374 0.81312070869375 0.9535809498644956 3.760356568734428 0.9946017028215539 0.08005635468386928 0.09726633589291724 0.10094048201008335 0.06955027691471354 0.2115336632891208 1.1979713780434055e-07 6.921553557995374 2.806775618869932 up LTGDVEELEIQEK(ub)PALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTGDVEELEIQEKPALK 17 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 18356200.0 2583800.0 4210400.0 11562000.0 True False 3539100.6845695386 4024370.606069106 8831293.72686457 1.0 1.1371167323990927 2.4953496704315214 21.754951375185346 -6.9263499189137745 0.7761592144606855 0.9763134101927351 2.7499334955360863 0.9957711939223722 0.043889637010579796 0.09457751200849546 0.08729040287031516 0.03914944923651328 0.12545302743424663 1.1848137376407355e-07 6.9263499189137745 1.7736200853433512 up LTGDVEELEIQEK(ub)PALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTGDVEELEIQEKPALK 17 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 15606000.0 3214100.0 5538600.0 6853300.0 True False 2672666.558772417 5508762.462473977 8286293.343921028 1.0 2.0611484228710553 3.10038426481716 21.349848427850805 -6.971381471641772 0.222733561706474 0.5369892252623022 4.6539824437334 0.9999912450267758 0.0025372151478068464 0.07585693435390056 0.007405463602213571 0.028192939553064632 0.10473083777086138 1.0681162647955694e-07 6.971381471641772 4.116993218471098 LTGDVEELEIQEK(ub)PALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTGDVEELEIQEKPALK 17 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 97920000.0 10407000.0 16033000.0 71480000.0 True False 13472066.652639037 15140749.455860298 58471373.44673605 1.0 1.1238624218723252 4.34019330176652 23.68346784543587 -6.915031171532488 0.8607785358176459 0.9155517941396832 4.803874870262418 0.9926855393929161 0.13223941955006752 0.1011840516806328 0.12141919019955655 0.11103528987379885 0.3183190055295686 1.216098711899834e-07 6.915031171532488 3.888323076122735 up LTGIK(ub)HELQANCYEEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTGIKHELQANCYEEVK 17 1 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 1 18675100.0 6213100.0 8337200.0 4124800.0 True False 8145434.267745983 7093322.258151068 3698005.2638754975 1.0 0.8708341415557139 0.45399731215298544 22.957560186334284 -6.949799731493189 0.5610427640163983 1.0054222065528233 0.2994524294867407 0.9991854388392656 0.006649629859746303 0.08356635515092152 0.03629665723112009 0.007119079050930306 0.03465830401345377 1.1225359759087985e-07 6.949799731493189 -0.7059697770660827 down LTGIK(ub)HELQANCYEEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTGIKHELQANCYEEVK 17 1 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 1 15067500.0 6213100.0 6684500.0 2169900.0 True False 8510250.972714217 6389156.687314502 1657414.310493292 1.0 0.7507600783807173 0.1947550449225688 23.020770247857175 -7.11803586049971 0.5194874457177228 1.0084943631646575 2.959755629291302e-24 0.9993162124985808 0.008801800419036842 0.0781244246514525 0.03355862322728746 0.009854193053934339 0.04377890194896601 7.620160863480372e-08 7.11803586049971 -1.0084943631646575 down LTGIK(ub)HELQANCYEEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTGIKHELQANCYEEVK 17 1 P23528;E9PK25;E9PP50;G3V1A4 P23528 CFL1 Cofilin-1 1 17458600.0 7542100.0 5923400.0 3993100.0 True False 9763397.127017291 5593757.582912924 3266396.77266595 1.0 0.5729314817517631 0.33455535303661577 23.21895178325571 -9.33708198265508 0.16343206986090436 1.5342807760638644 2.1720026605748344e-21 0.9997438075726769 0.0044061815600999026 0.7701415215887278 0.06076037426379692 0.3682711062661142 0.17013245262683238 4.6016969820935915e-10 9.33708198265508 -1.5342807760638644 LTGK(ub)DVNFEFPEFQL ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTGKDVNFEFPEFQL 15 1 P62081 P62081 RPS7 40S ribosomal protein S7 1 44911000.0 6799200.0 7689800.0 30422000.0 True False 10314883.488102313 6317495.109318369 24409078.36556371 1.0 0.612464029923874 2.3663939969577283 23.298224189547778 -6.848777471191666 1.2411286971134587 0.793408529509511 2.4348122480798495 0.9384849156436218 0.1865851854745775 0.15880963898840358 0.4713917658160197 0.11767891066311928 0.2720870557565582 1.4165194065660975e-07 6.848777471191666 1.6414037185703385 up LTGK(ub)DVNFEFPEFQL ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTGKDVNFEFPEFQL 15 1 P62081 P62081 RPS7 40S ribosomal protein S7 1 10561100.0 4925700.0 3494100.0 2141300.0 True False 4095937.795508947 3475276.5897754487 2589035.9297474353 1.0 0.8484690840729974 0.6320984494896926 21.965762374800708 -6.966063144889807 0.3393146457731901 1.0236556033391058 0.449728838458699 0.9999334082186319 0.0012319647165773056 0.07760205755542328 0.013598225306014688 0.0030608123517333087 0.0187372322288595 1.0812767260362153e-07 6.966063144889807 -0.5739267648804067 LTGMAFR ddPTM_RPMI8226_Bortezomib_1h_R1 2 LTGMAFR 7 0 P04406;E7EUT5;O14556;P04406-2 P04406;P04406-2 GAPDH;GAPDHS Glyceraldehyde-3-phosphate dehydrogenase;Glyceraldehyde-3-phosphate dehydrogenase, testis-specific 0 161407900.0 34037800.0 66013900.0 61356200.0 False True 44623885.42252412 56164883.44016673 55007648.994229406 1.0 1.2586282639524984 1.232695191675623 25.41131279939297 -10.290236339223243 5.315923845928003 0.9999585746433773 1.245661727814007 0.9917114292716172 0.010587132423577313 5.1990113049304894e-06 6.941460094294037e-07 0.01025267273932479 0.00341698229670761 5.125823652802133e-11 10.290236339223243 0.24570315317062963 LTGMAFR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LTGMAFR 7 0 P04406;E7EUT5;O14556;P04406-2 P04406;P04406-2 GAPDH;GAPDHS Glyceraldehyde-3-phosphate dehydrogenase;Glyceraldehyde-3-phosphate dehydrogenase, testis-specific 0 77406840.0 35575500.0 13019140.0 28812200.0 False True 34446175.225544155 18217750.495918177 21265420.472527664 1.0 0.5288758585425906 0.6173521539993191 25.037840464572838 -10.07587907148301 5.265580585070629 1.0000058113698111 0.5731140062703991 0.9687881061012119 0.036120296368829304 2.4642515391947176e-06 4.3246838347238e-07 0.03497380272321804 0.01165777552441795 8.396937651881822e-11 10.07587907148301 -0.42689180509941205 LTGMAFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTGMAFR 7 0 P04406;E7EUT5;O14556;P04406-2 P04406;P04406-2 GAPDH;GAPDHS Glyceraldehyde-3-phosphate dehydrogenase;Glyceraldehyde-3-phosphate dehydrogenase, testis-specific 0 280981000.0 21225000.0 247520000.0 12236000.0 False True 32199876.755349364 203348122.1174132 9817549.236770673 1.0 6.315183243166636 0.30489400041382714 24.940551830663647 -6.6733309733126855 1.9257423169206525 4.383039145634105 0.32900519630590275 0.2936973469144818 2.256086149134205 0.453590961134899 3.246148097732928 0.9421323683191059 2.5060972368374634 2.121626966097063e-07 6.6733309733126855 -4.054033949328202 LTGMAFR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LTGMAFR 7 0 P04406;E7EUT5;O14556;P04406-2 P04406;P04406-2 GAPDH;GAPDHS Glyceraldehyde-3-phosphate dehydrogenase;Glyceraldehyde-3-phosphate dehydrogenase, testis-specific 0 146291700.0 34037800.0 65811800.0 46442100.0 False True 46622494.49695843 62904017.06548043 35473432.48507323 1.0 1.3492203225973716 0.7608651760876385 25.47452286091586 -6.745892515125383 1.6649096872521048 1.2063537833177225 0.7600432503771372 0.6311566714706305 0.1467250512807835 0.3072695415341823 1.6744086845427748 0.0696546761555178 0.16984747715873166 1.7951778659384746e-07 6.745892515125383 -0.4463105329405853 LTGMAFR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LTGMAFR 7 0 P04406;E7EUT5;O14556;P04406-2 P04406;P04406-2 GAPDH;GAPDHS Glyceraldehyde-3-phosphate dehydrogenase;Glyceraldehyde-3-phosphate dehydrogenase, testis-specific 0 56939840.0 35575500.0 12103240.0 9261100.0 False True 29582604.51187209 12038037.443814963 11197553.191511681 1.0 0.4069296007720976 0.3785181655326487 24.818245740007114 -13.659970410566075 0.4363084410950874 9.99999999999774 0.37813185499165886 0.9998788073249246 0.0031540864010453314 24.070515056681387 0.2223150470134958 205.5102048297864 0.006624224495097425 2.187910686016927e-14 13.659970410566075 -9.621868145006081 LTGMAFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTGMAFR 7 0 P04406;E7EUT5;O14556;P04406-2 P04406;P04406-2 GAPDH;GAPDHS Glyceraldehyde-3-phosphate dehydrogenase;Glyceraldehyde-3-phosphate dehydrogenase, testis-specific 0 67886000.0 21225000.0 23236000.0 23425000.0 False True 27476180.907299295 21942896.173914403 19161890.3607973 1.0 0.7986152168653495 0.6974000653674096 24.711678152756097 -13.999999999994348 0.08906380515275376 2.0354569833948926 0.4399902678801068 0.9998467780651016 0.0015568292624145977 12.172193134485982 0.086480851365163 2.3940630439183854 0.23147605383015218 1.0000000000130151e-14 13.999999999994348 -1.5954667155147857 LTGMAFRVPTANVSVVDLTCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTGMAFRVPTANVSVVDLTCR 21 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 15158800.0 3723000.0 9668900.0 1766900.0 False True 5099493.710291979 9241696.027223459 1349594.6104477593 1.0 1.8122771695102868 0.2646526669351429 22.281922589367365 -6.764053351443836 1.5969859183163317 1.4694069364996916 0.25777585103669703 0.7074515777403961 0.3418752248772742 0.2761199773760143 1.3887224927394106 0.1688312877983986 0.4041580696830969 1.7216570628990558e-07 6.764053351443836 -1.2116310854629946 LTGNK(ub)VQQYHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTGNKVQQYHR 11 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 5192170.0 481050.0 2180620.0 2530500.0 True False 630661.2084948273 1855279.9959901853 2268668.1342700087 1.0 2.941801352295164 3.5972850457768666 19.2665056712684 -9.572245044999628 0.31231038556593804 2.039048465592198e-16 3.8232832152785106 0.9986700143596887 0.04021913587059172 0.9425838460945087 0.12815310152869924 1.1841468614069581 0.21951855154000244 2.6776570654136886e-10 9.572245044999628 3.8232832152785106 LTGNK(ub)VQQYHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTGNKVQQYHR 11 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 16672450.0 1257550.0 2658600.0 12756300.0 True False 1907795.2892197692 2184152.058263391 10235011.713715082 1.0 1.1448566156993936 5.364837501984237 20.86347494450829 -6.91418752993439 0.866729302239569 0.8860021698754935 5.962026955452751 0.9924082705393521 0.17638052002437496 0.10171363471351436 0.12422766322906736 0.1474643491897019 0.41990806230831845 1.2184633484160096e-07 6.91418752993439 5.076024785577258 up LTGNK(ub)VQQYHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTGNKVQQYHR 11 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 13589100.0 1257550.0 1911750.0 10419800.0 True False 1627923.265016454 1805359.4319366901 8523503.31617655 1.0 1.1089954119664496 5.235813935056945 20.63460126660074 -6.91256543712786 0.8780766428505253 0.8823581319563162 5.799482669951407 0.9918543521977505 0.17794271263256684 0.10274605348889027 0.12974387221950223 0.14755777624392685 0.41494672814781747 1.2230228267458553e-07 6.91256543712786 4.9171245379950905 up LTGPGLSEGPEPSISVMVTGGPWPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTGPGLSEGPEPSISVMVTGGPWPTR 26 0 Q8WU39;Q8WU39-3 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 15046600.0 7447500.0 1429400.0 6169700.0 False True 7211083.189055397 2000166.8742225247 4553670.482967427 1.0 0.27737398415515063 0.6314821731468511 22.781784554740884 -10.637033653670917 6.661008506917867 1.0020851153719037 0.4544280786528032 0.7599027442654838 0.14456406279511622 0.004488942227218777 0.00024460744340796056 0.1403646434864197 0.04665785063879737 2.3065684447887522e-11 10.637033653670917 -0.5476570367191005 LTGPGLSEGPEPSISVMVTGGPWPTR ddPTM_RPMI8226_Bortezomib_8h_R1 2 LTGPGLSEGPEPSISVMVTGGPWPTR 26 0 Q8WU39;Q8WU39-3 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 232343700.0 63998700.0 103359000.0 64986000.0 False True 97090706.83168794 84913778.90244703 52141488.61562434 1.0 0.8745819417058083 0.537038922849892 26.532829876957322 -6.953862948634924 0.5146949235246672 1.0059800767822291 0.3907133145696138 0.999470582010032 0.004498374978005822 0.08197072719585916 0.029822773231686472 0.005140226751448991 0.027867902286266413 1.1120826145267558e-07 6.953862948634924 -0.6152667622126153 LTGPGLSEGPEPSISVMVTGGPWPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTGPGLSEGPEPSISVMVTGGPWPTR 26 0 Q8WU39;Q8WU39-3 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 14000600.0 7447500.0 2883900.0 3669200.0 False True 6192926.230191214 2868363.8582906676 4436412.755536022 1.0 0.4631677742756034 0.7163677703616118 22.56218983017516 -10.413183235890322 6.0609188786065005 1.000113862567227 0.5897677723186104 0.7777789129630482 0.10336846554757015 0.0001590846919784322 1.5402528748646303e-05 0.10011361053127424 0.033362028799062776 3.862039969402801e-11 10.413183235890322 -0.41034609024861657 LTGPGLSEGPEPSISVMVTGGPWPTR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LTGPGLSEGPEPSISVMVTGGPWPTR 26 0 Q8WU39;Q8WU39-3 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 146647000.0 63998700.0 38946100.0 43702200.0 False True 82847578.75297879 36778715.29862667 35748848.02243916 1.0 0.44393228929824685 0.43150142177394424 26.30395619904977 LTGTAIDCYK(ub)YLEPLYNDYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTGTAIDCYKYLEPLYNDYR 20 1 Q8NAV1 Q8NAV1 PRPF38A Pre-mRNA-splicing factor 38A 1 52641700.0 8466100.0 2495600.0 41680000.0 True False 10959533.341780296 2356717.666191289 34094667.672914945 1.0 0.2150381401009961 3.1109598018136526 23.385683033693134 -6.834497035276275 1.307534054993419 0.5816713787155242 3.1963845090545036 0.9145964079345216 0.3573699457625477 0.17532963572172938 0.5846000864343472 0.21447874625445226 0.49366964321220774 1.4638715306774583e-07 6.834497035276275 2.6147131303389792 up LTGTANK(ub)ASLCISTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTGTANKASLCISTK 15 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 8016800.0 2988100.0 3589400.0 1439300.0 True False 3917428.0368015664 3053875.511371617 1290375.0427404954 1.0 0.7795613557371158 0.32939342615060224 21.90147534194083 -6.959635150111267 0.44054943371662186 1.0160041965740407 0.07538328860819643 0.9997564167445493 0.004355599448667069 0.07983176149818273 0.021615186744547772 0.005939268410099479 0.03729534724573197 1.0973997322256546e-07 6.959635150111267 -0.9406209079658443 down LTGTANK(ub)ASLCISTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTGTANKASLCISTK 15 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 10658300.0 4598800.0 3956600.0 2102900.0 True False 4452813.611255848 5536491.013396419 1552087.4043522687 1.0 1.2433691361797055 0.3485632994897638 22.08628579310932 -6.834238900639052 1.308781091030859 1.1297100814344698 0.3223167311684128 0.914106089471383 0.11071056864747007 0.17563519604822087 0.5868486532489325 0.06638459563027499 0.1527889983100943 1.4647418808313174e-07 6.834238900639052 -0.8073933502660571 down LTGTANK(ub)ASLCISTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTGTANKASLCISTK 15 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 8106300.0 2988100.0 3334700.0 1783500.0 True False 4092881.320366226 3187361.927621762 1362274.032335491 1.0 0.7787574762457468 0.3328398567426813 21.964685403463722 -6.959893660626434 0.4369336639297697 1.016463562124696 0.07783641905551 0.9997662248467919 0.004242391475282154 0.07973917929292573 0.021272186550252897 0.005857549799530508 0.03696923588671278 1.0967467076842202e-07 6.959893660626434 -0.938627143069186 down LTGTANK(ub)ASLCISTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTGTANKASLCISTK 15 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 12687900.0 4598800.0 4914300.0 3174800.0 True False 3824105.9613834615 4887825.690487825 3838636.0013833395 1.0 1.2781616774864517 1.003799591367657 21.866691068543595 -10.724541006562823 3.3974536782302533 0.9836582543494231 1.1409806344377156 0.2603846501606456 0.11200785266168346 62582073.31804348 82917.89655525265 7999684.099745244 0.040990676330444516 1.8856409167944895e-11 10.724541006562823 0.15732238008829247 LTGVFAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTGVFAPR 8 0 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 27670400.0 5403400.0 11517000.0 10750000.0 False True 7083909.726600036 9798708.492914382 9637693.12128142 1.0 1.3832345231786756 1.3605047908913837 22.756114396629094 -10.223433095727788 5.035657353760965 0.9999543070823742 1.371869657035289 0.9972058263448379 0.009279374349954121 4.760972765218301e-06 7.342189044641627e-07 0.008985817137136311 0.002994905193244683 5.978151326783386e-11 10.223433095727788 0.37191534995291486 LTGVFAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTGVFAPR 8 0 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 11578300.0 4237700.0 2308900.0 5031700.0 False True 4103176.5330997068 3230855.8107544403 3713746.822235635 1.0 0.7874035603127512 0.9050906760353592 21.968309794709565 -10.096258311901686 4.685327463510239 1.0000089639059289 0.846247118202431 0.6947277997300538 0.048045563812842466 66862949.209960006 2.6083944145102858 6466.080204346166 0.016447274428796434 8.012013789696464e-11 10.096258311901686 -0.15376184570349782 LTGVFAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTGVFAPR 8 0 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 23933200.0 5403400.0 8770400.0 9759400.0 False True 7401183.001394481 8382894.728165615 7454430.721152236 1.0 1.1326425419539237 1.007194487657949 22.819324458151986 -10.853268508979262 3.0204778004096746 0.9748007770261736 1.0699185148366035 0.2928793610868763 0.05121395380208108 28958204.294140052 43207.5240109835 5074847.998569543 0.018742387739710525 1.4019466623238233e-11 10.853268508979262 0.09511773781042987 LTGVFAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTGVFAPR 8 0 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 7860900.0 4237700.0 2063300.0 1559900.0 False True 3523835.3119410966 2052184.593367017 1886067.8778373043 1.0 0.5823724469792477 0.5352315618854413 21.74871507014384 -13.999999999999998 0.3079410460950505 4.988678622555684 0.5245598376423015 0.9996674608736811 0.0038088994903407074 17.124494684348917 0.17649185318932434 43.716013249797854 0.016475074524389947 1.0000000000000041e-14 13.999999999999998 -4.464118784913382 LTGVFAPRPSTGPHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTGVFAPRPSTGPHK 15 1 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 10772400.0 4633000.0 2803000.0 3336400.0 False True 6073907.866035822 2384803.326008425 2991181.333008676 1.0 0.39263080352993296 0.49246406086184036 22.53419359402623 -10.433604510809564 6.78003367679178 1.0000805421887529 0.4425474321965813 0.9765105496855337 0.04075675663719011 4.962757295743299e-05 4.145754025279439e-06 0.039468198526118596 0.013154186641772153 3.684643620644735e-11 10.433604510809564 -0.5575331099921715 LTGVFAPRPSTGPHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTGVFAPRPSTGPHK 15 1 P62701;C9JEH7;P22090;Q8TD47 P62701 RPS4X;RPS4Y1;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 1;40S ribosomal protein S4, Y isoform 2 0 9325300.0 4633000.0 2461900.0 2230400.0 False True 6345945.302117301 2353125.117585392 1703625.4565299032 1.0 0.3708076583641969 0.2684588938958385 22.597403655549122 -13.999999999999998 0.25557123923173514 5.501594611360622 0.2294332939465268 0.9995534351856357 0.006834920419415566 14.225862104306108 0.15996892453424533 32.985759728557774 0.045814281315745026 1.0000000000000041e-14 13.999999999999998 -5.272161317414095 LTHYDHVLIELTQAGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTHYDHVLIELTQAGLK 17 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 12005200.0 3350400.0 2618500.0 6036300.0 False True 3244043.3859162414 3664080.7052971036 4455211.944881638 1.0 1.1294795628210217 1.3733515292130767 21.62936168364744 -6.961201786018692 0.4181541315003612 0.9890038085386686 1.5229989237680424 0.9998122004716186 0.0021211863978138215 0.07927462145169865 0.019565693094106638 0.0031511790977712434 0.02031100943960544 1.0934481999596721e-07 6.961201786018692 0.5339951152293737 LTHYDHVLIELTQAGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTHYDHVLIELTQAGLK 17 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 8489100.0 3350400.0 2778400.0 2360300.0 False True 2786006.0478862235 2763432.2077307785 2853827.8172058393 1.0 0.9918974188255721 1.0243437265224435 21.409766959081715 -6.8405725312914205 1.2796354382433137 0.9956896975004405 1.0254236877754925 0.9254448810821286 0.003764835781564965 0.1681351558526619 0.5345403377086898 0.0023067015601388307 0.0053153308609027354 1.4435355000585824e-07 6.8405725312914205 0.02973399027505208 LTHYDHVLIELTQAGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTHYDHVLIELTQAGLK 17 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 15700600.0 2418400.0 7817000.0 5465200.0 False True 3130666.473790937 7381977.07830475 4470589.677687493 1.0 2.3579570484766084 1.4279993461820408 21.57803838816868 -10.360178308363613 5.94094153913984 0.9998588445698099 1.8929781973293256 0.5514493027225755 0.3796536421654627 0.0007099194283808774 7.64566252790417e-05 0.36765477716771555 0.1225326861194851 4.363366486425831e-11 10.360178308363613 0.8931193527595157 LTIAEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTIAEER 7 0 P62701;Q8TD47 P62701 RPS4X;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 2 0 13939740.0 538040.0 7809000.0 5592700.0 False True 705375.650386772 6643927.639243583 5014021.052966568 1.0 9.41899204431083 7.108299032178495 19.4280322491341 -9.35446253944819 8.591825195154552 1.0000000010165 8.26364554078395 0.9294552098274089 0.9433364719966556 0.0 0.0 0.9133816114752069 0.3044605371584022 4.4211725054436557e-10 9.35446253944819 7.26364553976745 LTIAEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTIAEER 7 0 P62701;Q8TD47 P62701 RPS4X;RPS4Y2 40S ribosomal protein S4, X isoform;40S ribosomal protein S4, Y isoform 2 0 9544740.0 538040.0 4616500.0 4390200.0 False True 736967.9279842853 4412527.765275989 3353325.179007163 1.0 5.987408132325236 4.550164331002837 19.491242310656993 -9.941935879413279 7.346469454427008 0.9999999285155636 5.2687862316640395 0.9216432882651422 0.5867523248696629 6.880199383201608e-07 1.0140622508052427e-07 0.5681205295039391 0.18937349854738927 1.1430470853553228e-10 9.941935879413279 4.268786303148476 LTIAFQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTIAFQAK 8 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 34612700.0 8724700.0 12296000.0 13592000.0 False True 11438166.190114994 10461484.729432603 12185630.223670421 1.0 0.9146120589219581 1.0653482403675334 23.447352436564355 -6.752996550876464 1.6387132759740914 0.9499759999025396 1.0657197118439063 0.6619067176793605 0.03588688154814491 0.2947825384610335 1.5583450471034572 0.017293251161236065 0.0418527978728604 1.7660518464384014e-07 6.752996550876464 0.11574371194136679 LTIAFQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTIAFQAK 8 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 36900000.0 13672000.0 10092000.0 13136000.0 False True 13237989.843674425 14121788.22908476 9695287.528447093 1.0 1.0667622800626821 0.7323836657179369 23.65818073328013 -6.854789829363908 1.2116643933973639 1.0358333467990855 0.7177222468092677 0.9469970590086224 0.03326400235998088 0.15226994739463995 0.42777639527114897 0.021451788205720038 0.04982021552106861 1.3970442771958565e-07 6.854789829363908 -0.3181110999898178 LTIAFQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTIAFQAK 8 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 28290100.0 13672000.0 5838600.0 8779500.0 False True 11368873.772295963 5807146.302928637 10615252.858178478 1.0 0.5107934540604785 0.9337119112049662 23.438586008714406 -10.191693055490296 7.836214826130353 1.0000001287013227 0.7222526826327227 0.3651099799210561 0.17265573713485163 3.8826482684607076e-07 4.0054505712837525e-08 0.16717327586004563 0.05572439954587051 6.431421076042446e-11 10.191693055490296 -0.2777474460686 LTIAFQAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTIAFQAK 8 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 145632000.0 36332000.0 60123000.0 49177000.0 False True 47032490.21078906 56777102.19763541 40227290.5986309 1.0 1.2071889441357067 0.855308541358138 25.487154384237456 -6.747161837428841 1.6603895688083548 1.1222470601016457 0.8547607788626203 0.6365991411471269 0.08705301847543387 0.3050484118078979 1.6537388275766334 0.04143298327019149 0.10088802980002358 1.7899387190094157e-07 6.747161837428841 -0.2674862812390254 LTIEFTEEYPNKPPTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTIEFTEEYPNKPPTVR 17 1 A0A0D9SG71;A0A0D9SEZ6;P49459;A0A0R4J2E5 A0A0D9SG71 UBE2A Ubiquitin-conjugating enzyme E2 A 0 33431700.0 3758100.0 21977000.0 7696600.0 False True 5701312.453911827 18055032.642915275 6175363.636460377 1.0 3.1668204100140525 1.083147728944989 22.44286263821433 -6.637031703541067 2.055176845279616 2.420151195892218 1.091752879307509 0.14333337510446653 0.9278080337383731 0.540887863743935 4.362576675069588 0.36810608468099837 1.0274163756898917 2.3065788020883792e-07 6.637031703541067 -1.328398316584709 LTIELHPDGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTIELHPDGR 10 0 Q15545 Q15545 TAF7 Transcription initiation factor TFIID subunit 7 0 3270210.0 786900.0 897610.0 1585700.0 False True 1031633.5203504405 763690.0868563752 1421626.9751084594 1.0 0.7402726567056038 1.3780348806672549 19.97649912509174 -6.796129314416522 1.4717368395474022 0.8559954626727957 1.3860164530916015 0.8206388332573675 0.1108980748596755 0.2262955354180536 0.9680558574732866 0.05929265412954554 0.13822622233302745 1.5990818191994411e-07 6.796129314416522 0.5300209904188058 LTIELHPDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTIELHPDGR 10 0 Q15545 Q15545 TAF7 Transcription initiation factor TFIID subunit 7 0 3442610.0 786900.0 996610.0 1659100.0 False True 1077838.1951729131 952576.4748514466 1267254.7502370714 1.0 0.8837843000160415 1.1757374677502228 20.03970918661463 -6.798680669216592 1.4612030133539997 0.9357708362516315 1.1796417465974807 0.8283033789334916 0.04972861282301474 0.2226456979317808 0.9386228036008782 0.02677459277160477 0.06232105080060645 1.589715214787435e-07 6.798680669216592 0.24387091034584918 LTIGLGDLNIQQNSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTIGLGDLNIQQNSK 15 0 A0A087X170;Q8NET8-3;Q8NET8;Q8NET8-2 A0A087X170 TRPV3 Transient receptor potential cation channel subfamily V member 3 0 25927300.0 7664600.0 9291400.0 8971300.0 False True 11627758.55731687 7633277.075960461 7198118.622739528 1.0 0.6564702077647763 0.6190461031038564 23.471069684505068 -13.999999999999998 0.3130729861750774 4.381053828526989 0.6110282318219372 0.999678728898634 0.0030729733201820203 17.491604599686102 0.17815035495649006 38.59103128562404 0.012807779492116582 1.0000000000000041e-14 13.999999999999998 -3.7700255967050516 LTIGLGDLNIQQNSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTIGLGDLNIQQNSK 15 0 A0A087X170;Q8NET8-3;Q8NET8;Q8NET8-2 A0A087X170 TRPV3 Transient receptor potential cation channel subfamily V member 3 0 17527900.0 7664600.0 3148600.0 6714700.0 False True 9921975.791853288 2973377.642158157 5492693.498640158 1.0 0.29967596218079173 0.553588681717011 23.242196006597517 -10.279794949137942 5.620085976705213 1.0000513829341573 0.426632321949236 0.8717761666997633 0.10365943367772787 6.674380139014396e-05 8.553178978225689e-06 0.10037676338203468 0.03345593835925578 5.25055305053286e-11 10.279794949137942 -0.5734190609849212 LTIGSNLSIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTIGSNLSIR 10 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 26433700.0 8509000.0 7705700.0 10219000.0 False True 11155381.401273223 6556039.596583343 9161635.907569751 1.0 0.5877019673962083 0.8212750042346455 23.4112365042229 -10.163740558661335 5.38620066751267 1.0000092536537686 0.7044884858153507 0.6809428260921426 0.0953557929880123 1.0596387959557915e-05 1.645066121826919e-06 0.09233073891433981 0.03077594985054246 6.85897849696414e-11 10.163740558661335 -0.29552076783841785 LTIGSNLSIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTIGSNLSIR 10 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 32216300.0 10011000.0 7640300.0 14565000.0 False True 9693206.284744358 10691111.633638153 10749989.559366023 1.0 1.10294894378389 1.1090230872611142 23.208542523507468 -13.348080590570259 0.40935900277109216 0.0003686687804881349 1.1093120904517462 0.9998375693979674 0.0006375183527706223 16.246727968891786 0.21118107674270986 14.183315356593829 0.0015153054251820957 4.4866212548213405e-14 13.348080590570259 1.1089434216712581 LTIGSNLSIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTIGSNLSIR 10 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 194693000.0 45394000.0 75684000.0 73615000.0 False True 68866016.7459284 62177598.87820894 59064962.983399294 1.0 0.9028778171910907 0.8576793863555556 26.037288897258588 -13.999999995130205 0.10230809082752637 1.4765668628774677 0.7647656163148683 0.9997820983405871 0.0008764757897280921 12.06325241062405 0.09571438826225463 1.2069183890393054 0.0827641645397111 1.000000011213118e-14 13.999999995130205 -0.7118012465625995 LTIGSNLSIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTIGSNLSIR 10 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 34341900.0 8509000.0 7674900.0 18158000.0 False True 11655007.247078814 7335797.540499665 13869454.37574873 1.0 0.6294116670187652 1.1899996354978621 23.47444656574579 -6.728446220283875 1.729003851259743 0.7765962843191107 1.1895662712330244 0.5520141087606617 0.15580622943505726 0.33915129203926303 1.9855786132062703 0.07143408940238409 0.17756417674934924 1.8687610760462e-07 6.728446220283875 0.41296998691391373 LTIGSNLSIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTIGSNLSIR 10 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 23422100.0 10011000.0 7418400.0 5992700.0 False True 8324590.062496712 7378435.606762882 7245745.862885833 1.0 0.8863422164177944 0.870402723556178 22.988947798941744 -13.99999999999993 0.27673819452882514 1.9098680916865118 0.8654479741987618 0.9995979743545165 0.0011569811861685717 15.224342825779669 0.1665976729395077 7.824657483452138 0.006404398760262639 1.0000000000001595e-14 13.99999999999993 -1.0444201174877499 LTIGSNLSIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTIGSNLSIR 10 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 208721000.0 45394000.0 102100000.0 61227000.0 False True 58763427.84951451 96418045.24688677 50084314.242072016 1.0 1.640783200969842 0.8523041639152064 25.808415219351037 -6.690541329224968 1.8642675875158299 1.401518587443859 0.8549931400514932 0.37307843621946113 0.2709752506705291 0.41549649071430594 2.8001343239672236 0.11625571139513051 0.3025566294624216 2.0391945923435828e-07 6.690541329224968 -0.5465254473923657 LTIHGDLYYEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTIHGDLYYEGK 12 0 Q13435;E9PPJ0;H0YEX5 Q13435 SF3B2 Splicing factor 3B subunit 2 0 13643200.0 5843000.0 5393800.0 2406400.0 False True 5657517.163296496 7547572.4682954205 1776091.649547436 1.0 1.3340785808412177 0.31393482304745696 22.43173762554903 -6.818480628251306 1.3783644351364328 1.1803461157901918 0.292367487286575 0.8808775222925426 0.14656597213436512 0.19545644057116904 0.7300704311818206 0.08356717175367795 0.19269794329575196 1.5188656896764778e-07 6.818480628251306 -0.8879786285036168 down LTIHGDLYYEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTIHGDLYYEGK 12 0 Q13435;E9PPJ0;H0YEX5 Q13435 SF3B2 Splicing factor 3B subunit 2 0 9727500.0 3081900.0 3361700.0 3283900.0 False True 4221361.715215908 3213168.9783447003 2508310.4540434647 1.0 0.7611688348721279 0.5941946280040996 22.009277023919456 -7.586182222921649 0.10061848050333932 1.4533665534147953 7.222579180333704e-10 0.9999963275502289 0.0003190852778158851 0.13710432593388275 0.01000283491342351 0.05852776040933503 0.08054405439392624 2.5930911148497175e-08 7.586182222921649 -1.4533665526925375 LTIHGDLYYEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTIHGDLYYEGK 12 0 Q13435;E9PPJ0;H0YEX5 Q13435 SF3B2 Splicing factor 3B subunit 2 0 8961100.0 5843000.0 1734000.0 1384100.0 False True 4858713.3887891555 1724658.5978279475 1673508.9106446654 1.0 0.35496199504324977 0.3444345810777948 22.212142900983306 LTIHGDLYYEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTIHGDLYYEGK 12 0 Q13435;E9PPJ0;H0YEX5 Q13435 SF3B2 Splicing factor 3B subunit 2 0 41380900.0 15783000.0 16453000.0 9144900.0 False True 20431404.62944192 15537376.086650645 7480622.034597886 1.0 0.7604653898470144 0.3661335170181208 24.28428505488428 -6.963665183800673 0.3802662323176403 1.0270058438642766 0.08564259256755515 0.9998829295541414 0.002827609074128538 0.07841689199855055 0.016475369875242243 0.005130445916436227 0.03331642981032528 1.0872635185609131e-07 6.963665183800673 -0.9413632512967215 down LTIQANLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTIQANLNR 9 0 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 0 7153400.0 2046300.0 2269200.0 2837900.0 False True 2682719.1163973887 1930644.2052723218 2544261.3310590275 1.0 0.7196594654549505 0.9483890115472485 21.35526458009339 -9.976879653787785 6.136598305794625 1.0000000874110444 0.8340242389428295 0.4124818402819008 0.09337844617080611 1.1167697080010388e-07 1.8661393798099877e-08 0.09041333888262852 0.03013776390951413 1.0546791152827811e-10 9.976879653787785 -0.1659758484682149 LTIQANLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTIQANLNR 9 0 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 0 24433300.0 5775400.0 8857700.0 9800200.0 False True 8761704.038296575 7276974.229474015 7863186.174419739 1.0 0.830543259355378 0.8974494162380401 23.062780051995393 -10.278344485671258 4.635250072050861 1.0000614464543884 0.8639963377962623 0.846377042715551 0.027314324170381314 1.735234957121759e-05 2.701537738748994e-06 0.02645891786590358 0.008815660218517402 5.2681182452181516e-11 10.278344485671258 -0.13606510865812615 LTIQANLNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTIQANLNR 9 0 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 0 5493240.0 2428400.0 968840.0 2096000.0 False True 2019322.1963607038 963620.6666203177 2534263.909190972 1.0 0.47720005671060817 1.2550072067539866 20.94543969000166 -6.725606668811263 1.7391820295404186 0.683854843908119 1.2541920352155604 0.538826202169884 0.21985858941590913 0.3445300537289039 2.0394758379728866 0.10026330677861693 0.2500500073193597 1.8810196446896225e-07 6.725606668811263 0.5703371913074414 LTIQANLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTIQANLNR 9 0 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 0 23032400.0 5775400.0 9681200.0 7575800.0 False True 7476369.150153895 9142432.709541233 6197082.134272281 1.0 1.2228439401434643 0.8288892656062494 22.833906374087842 -6.753245573050856 1.6377242588606509 1.13052457484798 0.8279046533819775 0.662806270262265 0.09366018036009888 0.2944463491740892 1.5547479694575725 0.04515749639918122 0.10926395018819042 1.7650394918546014e-07 6.753245573050856 -0.3026199214660025 LTISPDYAYGATGHPGIIPPHATLVFDVELLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTISPDYAYGATGHPGIIPPHATLVFDVELLK 32 0 P62942;Q5W0X3;Q1JUQ5;Q5VVH2 P62942 FKBP1A;FKBP12-Exip2;FKBP1C Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 760277000.0 247843000.0 250774000.0 261660000.0 False True 375995950.75034374 206021420.39379498 209942786.31034803 1.0 0.5479352104262166 0.5583644874137148 28.486141884129857 -9.932335093727445 4.8791205521845855 1.0000026380801945 0.5531498489023658 0.9995916154851204 0.0042577345695771415 2914551.49168039 0.24246612246399477 90.37142223277603 0.0014575357818839593 1.1685973745839136e-10 9.932335093727445 -0.44685278917782867 LTISPDYAYGATGHPGIIPPHATLVFDVELLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTISPDYAYGATGHPGIIPPHATLVFDVELLK 32 0 P62942;Q5W0X3;Q1JUQ5;Q5VVH2 P62942 FKBP1A;FKBP12-Exip2;FKBP1C Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 429805000.0 247843000.0 67227000.0 114735000.0 False True 320837649.215914 63485758.35271749 93854407.28051561 1.0 0.19787502653715525 0.29252928236409825 28.257268206222307 -10.624564790143182 6.588346011046467 1.0025370766270696 0.2452021547076444 0.988342969376047 0.03864243812647863 0.0014427431545189207 8.22142035097802e-05 0.03748545786434168 0.012471793276725195 2.37375126866774e-11 10.624564790143182 -0.7573349219194252 LTISSPLEAHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTISSPLEAHK 11 0 Q15393;Q15393-2 Q15393 SF3B3 Splicing factor 3B subunit 3 0 6704780.0 627380.0 3565700.0 2511700.0 False True 822501.255556562 3033711.458989735 2251813.377927678 1.0 3.688397359268362 2.737762845606775 19.649658355575077 -10.31119581606242 5.841938731346615 0.9997905702833064 3.2130801024375626 0.8784361731720375 0.38809491505831717 0.0010587151440400006 0.00012483118198421884 0.3758038215354584 0.12525709523071618 4.884320838925824e-11 10.31119581606242 2.2132895321542563 LTISSPLEAHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTISSPLEAHK 11 0 Q15393;Q15393-2 Q15393 SF3B3 Splicing factor 3B subunit 3 0 3784810.0 1202300.0 402910.0 2179600.0 False True 1164133.6446057458 563794.0641478926 1608697.3734015927 1.0 0.4843035563488343 1.3818837560926316 20.15082526102583 -6.750908069339554 1.6466315197927124 0.6970961507765273 1.383776572758271 0.6528230163460866 0.2167084739226524 0.29845722757085275 1.5924708678656032 0.10395533086011413 0.2521206805407735 1.7745650778211892e-07 6.750908069339554 0.6866804219817436 LTISSPLEAHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTISSPLEAHK 11 0 Q15393;Q15393-2 Q15393 SF3B3 Splicing factor 3B subunit 3 0 8559280.0 627380.0 4217800.0 3714100.0 False True 859339.340307004 4031443.6496005855 2836906.0742905815 1.0 4.691329094930448 3.30126405393832 19.71286841709797 -9.503303416752004 9.695400176663709 1.0000183213729248 3.996296574434385 0.8610137058102838 0.567491676717203 0.0 0.0 0.5494714695899421 0.18315715107157207 3.138315366071502e-10 9.503303416752004 2.99627825306146 LTISYCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTISYCR 7 0 J3KS15;Q14197 J3KS15 ICT1 Peptidyl-tRNA hydrolase ICT1, mitochondrial 0 19521600.0 5820500.0 6572500.0 7128600.0 False True 7630731.865802187 5591908.619404339 6391000.854359697 1.0 0.7328141936771468 0.8375344549847891 22.863390002337834 -10.139283306965622 5.457401604871132 1.0000043132983427 0.7851743244113782 0.848739731796315 0.042751867655959334 2.2436852382069346e-06 3.538958151316326e-07 0.04139514861313037 0.013798105954205985 7.256324451016437e-11 10.139283306965622 -0.21482998888696447 LTISYCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTISYCR 7 0 J3KS15;Q14197 J3KS15 ICT1 Peptidyl-tRNA hydrolase ICT1, mitochondrial 0 14894700.0 5820500.0 3586200.0 5488000.0 False True 7972496.143098161 3427749.8260224764 4191847.4289078633 1.0 0.42994687792855196 0.5257885803477963 22.926600063860725 -10.465555622851413 6.6350672968551505 1.0001484930498596 0.4778677291381741 0.9753526125985065 0.03912721116780278 8.59712852370998e-05 6.924879858028948e-06 0.03789533722349441 0.012628253103036748 3.423295405010935e-11 10.465555622851413 -0.5222807639116855 LTISYCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTISYCR 7 0 J3KS15;Q14197 J3KS15 ICT1 Peptidyl-tRNA hydrolase ICT1, mitochondrial 0 13798800.0 2645500.0 6771600.0 4381700.0 False True 3424651.900601188 6394754.507285204 3584275.560038662 1.0 1.867271387834373 1.0466101852306369 21.70752592183567 -10.229990421608946 3.9543153174232715 0.9996205450358099 1.456940786415314 0.2924672881403737 0.3350335338259107 41636588.72140129 26929359.907195244 136543.1865031756 0.11469089018799009 5.888566424812224e-11 10.229990421608946 0.4573202413795042 LTITFPAMVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTITFPAMVHR 11 0 B9ZVN9;O95602 B9ZVN9 POLR1A DNA-directed RNA polymerase;DNA-directed RNA polymerase I subunit RPA1 0 16810500.0 5309200.0 4858500.0 6642800.0 False True 6960412.614365933 4133630.7382846675 5955466.778237036 1.0 0.5938772551720665 0.8556197898304563 22.73074140112449 -10.404306669674751 6.6959095232898695 1.000028250166733 0.7247485225012614 0.5958805438685442 0.10685594231596605 4.506873214727125e-05 4.009430437024855e-06 0.10347342012240535 0.03448760708608639 3.941788610684539e-11 10.404306669674751 -0.2752797276654716 LTITFPAMVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTITFPAMVHR 11 0 B9ZVN9;O95602 B9ZVN9 POLR1A DNA-directed RNA polymerase;DNA-directed RNA polymerase I subunit RPA1 0 15898800.0 5309200.0 4016700.0 6572900.0 False True 7272154.715735194 3839228.9125493513 5020516.393124735 1.0 0.5279355380382905 0.6903753549496884 22.79395146264738 -10.183545837901532 5.571940496790204 1.0000110349419988 0.6091554464939587 0.8853081441918297 0.06631577755744981 9.090877528405343e-06 1.332092689752807e-06 0.06421178642219577 0.021403325172550763 6.553211158778184e-11 10.183545837901532 -0.39085558844804014 LTITQFMNHPWINQSMVVPQTPLHTAR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LTITQFMNHPWINQSMVVPQTPLHTAR 27 0 C9J8E1;Q16644 C9J8E1 MAPKAPK3 MAP kinase-activated protein kinase 3 0 87091400.0 32721700.0 24393500.0 29976200.0 False True 31682967.54445303 34133951.76042201 22124533.953276195 1.0 1.077359679535388 0.698310028005874 24.917204134135382 -6.853544134707134 1.2178637553127905 1.041443084395002 0.68208870177287 0.9453046408707486 0.03824493955969186 0.15360269074396737 0.43662813291538033 0.024548716815377764 0.05695123984739109 1.4010571967824063e-07 6.853544134707134 -0.35935438262213204 LTITQFMNHPWINQSMVVPQTPLHTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTITQFMNHPWINQSMVVPQTPLHTAR 27 0 C9J8E1;Q16644 C9J8E1 MAPKAPK3 MAP kinase-activated protein kinase 3 0 11199600.0 4796200.0 1223200.0 5180200.0 False True 6569484.752431462 1169154.9794185185 3956743.449567881 1.0 0.17796753070867502 0.6022912905161143 22.647348793104406 -10.887844776925851 7.946824200890475 1.0783357217747715 0.3901294106123947 0.7336424385689632 0.1732294495445859 0.08886888826040373 0.00125422399988814 0.06199834578838731 0.055909564429904926 1.2946584882714978e-11 10.887844776925851 -0.6882063111623768 LTITQFMNHPWINQSMVVPQTPLHTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LTITQFMNHPWINQSMVVPQTPLHTAR 27 0 C9J8E1;Q16644 C9J8E1 MAPKAPK3 MAP kinase-activated protein kinase 3 0 84980100.0 32721700.0 27323400.0 24935000.0 False True 27209543.367096048 27176203.420929752 30148793.213586237 1.0 0.9987746965938938 1.1080227553559228 24.697609409569658 -6.904363592908602 0.9332618085031581 0.9959855043007939 1.1205633479575414 0.988615172969088 0.005464479933149696 0.10826442769866335 0.15985591887475928 0.004352734640607731 0.01159439408299258 1.2463396372899345e-07 6.904363592908602 0.12457784365674751 LTIVSTVGFGDQINK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTIVSTVGFGDQINK 15 0 Q14141;B1AMS2;Q14141-2;Q14141-4;Q14141-3 Q14141 SEPT6 Septin-6 0 23477600.0 7845600.0 8836500.0 6795500.0 False True 11902348.790189357 7259557.535110379 5452366.446426547 1.0 0.609926466034515 0.4580916374187186 23.504742964936945 -13.99999999998142 0.13051184568260543 2.8538630709808763 0.24683317602920768 0.9996433051311747 0.004310778611062995 11.935973550905299 0.11239493120048283 5.673696233600933 0.18791500885932738 1.0000000000427836e-14 13.99999999998142 -2.6070298949516686 LTIVSTVGFGDQINK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTIVSTVGFGDQINK 15 0 Q14141;B1AMS2;Q14141-2;Q14141-4;Q14141-3 Q14141 SEPT6 Septin-6 0 20711400.0 7845600.0 7800100.0 5065700.0 False True 10156283.8598967 7366017.578161031 4143794.57847133 1.0 0.7252670051146001 0.40800302902458224 23.275869287029394 -6.969239002175123 0.2757576256395967 1.0735628315829766 0.050095136401818736 0.9999758227122169 0.0011893667961507329 0.07655041896526041 0.009910727192977108 0.006007229433882903 0.029280109939002718 1.0733985340334952e-07 6.969239002175123 -1.0234676951811579 down LTIYVCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTIYVCR 7 0 Q9NZI7;Q9NZI7-4 Q9NZI7 UBP1 Upstream-binding protein 1 0 15242800.0 3075900.0 3667100.0 8499800.0 False True 4032534.6870579766 3119982.9742438435 7620322.231838856 1.0 0.7737026997578277 1.889710274854059 21.943255512533064 -6.853925135986661 1.216082975902269 0.8787102439601454 1.9377969944440396 0.9458126148372771 0.11212977033157197 0.15319415565821973 0.434007215487164 0.07207318131174614 0.1672465748155378 1.399828605296183e-07 6.853925135986661 1.0590867504838943 LTK(ub)DAQHALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTKDAQHALR 10 1 P40938;P40938-2 P40938 RFC3 Replication factor C subunit 3 1 3766550.0 912650.0 1205500.0 1648400.0 True False 1196492.988115171 1025644.0990021963 1477839.3805693295 1.0 0.8572086165067194 1.2351425334279327 20.190380511506802 -6.804314907294993 1.4380239943578537 0.9216423403598919 1.2409459070670648 0.8445468772248873 0.0614355186934253 0.21464616560575542 0.875769418159565 0.03360121989409557 0.07795521535043012 1.5692245456661495e-07 6.804314907294993 0.31930356670717286 LTK(ub)DAQHALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTKDAQHALR 10 1 P40938;P40938-2 P40938 RFC3 Replication factor C subunit 3 1 4918300.0 1197200.0 1403400.0 2317700.0 True False 1816239.9270437798 1152952.3051857534 1859605.5791160015 1.0 0.6348017616055646 1.0238766098170775 20.79252336594662 -11.09042852060478 13.0899736522828 3.6051981771018244 0.829339185711321 0.20415818782791295 0.15883914164483715 0.03337309971694852 0.00023054947335583652 0.00042501305217622137 0.05126511252636129 8.120288876528833e-12 11.09042852060478 -2.7758589913905034 LTK(ub)DAQHALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTKDAQHALR 10 1 P40938;P40938-2 P40938 RFC3 Replication factor C subunit 3 1 3580050.0 912650.0 1017100.0 1650300.0 True False 1250081.3684388837 972161.1589000787 1260533.1289953825 1.0 0.7776783043444004 1.0083608641968251 20.253590573029694 -11.07349393825003 10.490684838851115 1.6314021043610134 0.8930195842706128 0.22285398233786313 0.09417576069958014 0.0427223582689723 0.00029929779294126936 0.0028011107222273303 0.030395096067157408 8.443180265603671e-12 11.07349393825003 -0.7383825200904006 LTK(ub)DAQHALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTKDAQHALR 10 1 P40938;P40938-2 P40938 RFC3 Replication factor C subunit 3 1 3482350.0 1197200.0 989050.0 1296100.0 True False 1549799.0003401032 934008.4980551756 1060223.0991090457 1.0 0.6026642795938103 0.6841036152922927 20.56364968803907 -10.119750805771591 5.351047922414714 1.0000069493639683 0.6433839474428685 0.9623586743625041 0.033247469576079144 2.7564727555605225e-06 4.5344149261468326e-07 0.032192351198619115 0.010730574664212171 7.59012964849925e-11 10.119750805771591 -0.35662300192109975 LTK(ub)DLEAEQQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTKDLEAEQQK 11 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 12247600.0 1232200.0 2251700.0 8763700.0 True False 1595107.1902932497 2126390.9155966216 7168796.523155582 1.0 1.3330708610282793 4.4942412439615715 20.605221944855654 -6.927062882567425 0.77052099228008 0.9463306990204742 5.097197504398392 0.9959287976872989 0.10046746774139821 0.09419189866370602 0.0853641366589038 0.08997940934833176 0.2907877320904543 1.1828702726257856e-07 6.927062882567425 4.150866805377918 up LTK(ub)EVTAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTKEVTAAR 9 1 Q9UMS4;F5GY56;F5H2I0 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 1 7770570.0 4256900.0 3035500.0 478170.0 True False 3539800.9626453114 3019147.1590004247 578153.1361917206 1.0 0.8529143844133543 0.16332927819751306 21.755236811474987 -6.983664542428542 0.6726454880179956 1.00561273556503 1.8847310257020736e-21 0.998283369227296 0.015111126155770096 0.0799567184925003 0.05391014771434989 0.014889695220833834 0.05349455846226753 1.0383301326965005e-07 6.983664542428542 -1.00561273556503 down LTK(ub)LQILSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTKLQILSLR 10 1 Q15404;Q15404-2 Q15404 RSU1 Ras suppressor protein 1 1 9890400.0 4850700.0 2033800.0 3005900.0 True False 4696717.183638935 2845906.946126888 2218564.614932942 1.0 0.6059353448065035 0.47236495794580435 22.163221292567332 -13.999999999999998 0.15105551725467709 2.9086303282880777 0.32717952958157315 0.9995627544464777 0.004683632953156962 11.96182895823126 0.12245668622633171 6.6992354798454805 0.13099726798614295 1.0000000000000041e-14 13.999999999999998 -2.5814507987065047 LTK(ub)LQILSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTKLQILSLR 10 1 Q15404;Q15404-2 Q15404 RSU1 Ras suppressor protein 1 1 16602600.0 2457100.0 3976500.0 10169000.0 True False 3727600.3380715637 3266862.5064636925 8159092.69276896 1.0 0.8763982750773573 2.1888324800909276 21.829815756250056 -6.883827530323324 1.0581751827740702 0.9186987978603492 2.2889680316639818 0.9766458360082179 0.09042548972459984 0.12429571797325278 0.25223141017717443 0.06558160122175506 0.1602601515672551 1.3066897057022611e-07 6.883827530323324 1.3702692338036324 up LTK(ub)LQILSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTKLQILSLR 10 1 Q15404;Q15404-2 Q15404 RSU1 Ras suppressor protein 1 1 6425600.0 3108100.0 1008300.0 2309200.0 True False 4257248.563244287 963749.9719977875 1763814.5194668449 1.0 0.22637860056340012 0.4143085594520018 22.021489894936174 -10.846313580062594 10.78947476529756 1.0149311642814567 0.32034358005334373 0.9457675924401338 0.0767220844432157 0.024755102228758735 0.00035261362834824756 0.0667350856872735 0.024761946277907794 1.4245786126142161e-11 10.846313580062594 -0.694587584228113 LTK(ub)LQILSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTKLQILSLR 10 1 Q15404;Q15404-2 Q15404 RSU1 Ras suppressor protein 1 1 11672300.0 4850700.0 3162700.0 3658900.0 True False 4033571.972445584 3145661.9073532023 4423959.073157845 1.0 0.7798700330233514 1.096784463839768 21.94362656800161 -6.7199076700246545 1.759796351957953 0.8660615097442717 1.096282899931454 0.5120218849066882 0.09263250071259102 0.3554932474823484 2.1515426553408887 0.041797645713554994 0.10493322730776111 1.905865857450484e-07 6.7199076700246545 0.23022139018718235 LTK(ub)QQLILAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTKQQLILAR 10 1 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 8789500.0 1752700.0 3772400.0 3264400.0 True False 2297806.673170946 3209572.6247000243 2926631.2023359076 1.0 1.3967983739340664 1.273662939753409 21.131825990724046 -10.1606556206225 4.866972239257438 0.9999724405392846 1.3352306568449437 0.9081080570613904 0.05026983050395196 1.5034186323642367e-05 2.592836108096382e-06 0.04867755109222493 0.016224518029278524 6.907873554075656e-11 10.1606556206225 0.3352582163056591 LTK(ub)QQLILAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTKQQLILAR 10 1 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 7352600.0 2399900.0 2960600.0 1992100.0 True False 2323716.4881388443 4142783.0193250366 1470309.2482810195 1.0 1.7828263647787574 0.6327403776605501 21.148002628554128 -6.723461534515643 1.7470478257800939 1.4745090850869071 0.6342034670577837 0.5286589377313917 0.3292857514107645 0.3486647687734099 2.0815971368564914 0.14955645586052776 0.3738961058839738 1.8903336507202286e-07 6.723461534515643 -0.8403056180291234 LTK(ub)QQLILAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTKQQLILAR 10 1 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 21745400.0 5742100.0 9037500.0 6965800.0 True False 8711185.503740478 7424687.514690208 5589006.576781394 1.0 0.8523165430815515 0.6415896635861493 23.054437637629768 -6.966074558678671 0.33910717030541243 1.0230940421541013 0.46381862461391676 0.999933608757426 0.0011983489299015693 0.07759820854924755 0.0135847398320242 0.0029828906507728165 0.018251287967741024 1.0812483091380134e-07 6.966074558678671 -0.5592754175401845 LTK(ub)QQLILAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTKQQLILAR 10 1 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 6920500.0 1752700.0 1690700.0 3477100.0 True False 2400720.554936542 1615999.2836027555 2655880.5931223677 1.0 0.673130939908777 1.1062847725701128 21.195036052246937 -6.704839543948436 1.8134779099749654 0.7979973706072989 1.1051252044159667 0.440604205887412 0.1378574224583603 0.38555391790512666 2.468293724537502 0.060568507037447414 0.15485011399700463 1.973151609379203e-07 6.704839543948436 0.3071278338086678 LTK(ub)QQLILAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTKQQLILAR 10 1 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 9422500.0 2399900.0 3788000.0 3234600.0 True False 1995623.1835966285 3767593.2921408694 3910939.904899385 1.0 1.8879282036354643 1.9597587044718838 20.928407903988404 -11.039416545488631 0.4471320562463209 1.8912450730259287e-21 1.9606870633179159 0.9996711251296291 0.007915706456577432 2.8850378588681864 0.21798060572079156 2.967226320030331 0.01629096825530269 9.13236907054453e-12 11.039416545488631 1.9606870633179159 LTK(ub)QQLILAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTKQQLILAR 10 1 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 24615100.0 5742100.0 10309000.0 8564000.0 True False 7433261.643712762 9735295.087660698 7005439.874060546 1.0 1.3096935846318627 0.9424449467598012 22.825563959722217 -6.683159856031433 1.8908032301934872 1.1953919821456653 0.9438120310192835 0.3385498830074646 0.13116642407396498 0.4315593473060061 2.985706701606583 0.055610515685389196 0.14607027230545333 2.074149919440964e-07 6.683159856031433 -0.2515799511263819 LTK(ub)SDRPELTGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTKSDRPELTGAK 13 2 P13804;P13804-2;H0YL12;H0YLU7;H0YNX6;H0YKF0;H0YK49 P13804 ETFA Electron transfer flavoprotein subunit alpha, mitochondrial 1 15555500.0 1673200.0 2044300.0 11838000.0 True False 2165990.383702858 1930532.9079158744 9683605.468137402 1.0 0.8912933882077267 4.470751828354309 21.046595407185006 -6.899894551497943 0.9619182065067818 0.8507483539941668 4.845693906591445 0.9865142426955912 0.19304488878492107 0.11148348083624453 0.17785097327697327 0.15054436865351523 0.3914908550489156 1.2592311212195818e-07 6.899894551497943 3.9949455525972786 up LTK(ub)TLATIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTKTLATIK 9 1 O00232;O00232-2 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 1 14691400.0 1649200.0 4544800.0 8497400.0 True False 2501956.9726700685 3733744.931315526 6817885.165457277 1.0 1.492329793078297 2.7250209495734388 21.254625548336588 -6.955429190237573 0.49567232463962263 0.9743595240940798 3.2957685069874385 0.9995613307146665 0.01519592481788039 0.0813761554463992 0.027486242288799635 0.017969360360326855 0.10167419093247228 1.1080792179804972e-07 6.955429190237573 2.3214089828933586 LTK(ub)TLATIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTKTLATIK 9 1 O00232;O00232-2 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 1 13326400.0 1649200.0 3942300.0 7734900.0 True False 2134921.910592133 3722907.5394397825 6327227.566776148 1.0 1.7438143854204073 2.96368102991704 21.025751870429037 -6.963731774546383 0.3791883385956598 0.9154384934201776 3.835139048967785 0.9998845689675038 0.008696998793120761 0.07839398936510393 0.016393813348898202 0.01588888954298326 0.10311789495216529 1.0870968202926236e-07 6.963731774546383 2.919700555547607 LTK(ub)VEELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTKVEELR 8 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 2580500.0 1227500.0 0.0 1353000.0 True False 1188533.6843995284 0.0 998608.7108700471 1.0 0.0 0.8402022794789907 20.180751360806045 -9.659534239253768 11.493676504120083 0.9999999981566734 0.42010113973949537 0.3884348924934866 0.3430111442411388 0.0 0.0 0.3321191123023702 0.11070637076745671 2.190109155694447e-10 9.659534239253768 -0.579898858417178 LTK(ub)VEELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTKVEELR 8 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 2689450.0 789170.0 1131300.0 768980.0 True False 1080947.4755173568 1081315.4252911785 587362.7616402281 1.0 1.0003403956086263 0.5433777079308205 20.043864991886426 -6.906727358931979 0.9177399153521788 1.015654105731536 0.48827856991079804 0.9896266806683169 0.02193166721589784 0.10662190468585296 0.1508034055180034 0.01767012459611591 0.04773891995996083 1.2395745214936346e-07 6.906727358931979 -0.5273755358207379 LTK(ub)VEELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTKVEELR 8 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 3431970.0 964970.0 1086100.0 1380900.0 True False 1249172.6874024305 1025657.5802413702 1129590.369230524 1.0 0.8210694890985452 0.9042707870754284 20.25254150026357 -10.179034295272457 4.752276308511855 1.0000172309337414 0.8626701380862672 0.784134953543093 0.03396678766591087 6.201872506159839e-06 1.0713632193811717e-06 0.03289232617305212 0.01096273357916873 6.621642119972268e-11 10.179034295272457 -0.13734709284747415 LTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAK 40 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 108082000.0 27171000.0 29060000.0 51851000.0 False True 41220393.4661766 23874015.9531837 41602627.122899376 1.0 0.5791797201735478 1.0092729259616704 25.296854940291823 -10.948574042409122 11.066689241715938 1.0554976669417893 0.794226323067622 0.2338374753751472 0.17558481600312348 0.10201171912002906 0.00047403918322151776 0.07213423303276115 0.056669755685582544 1.1257085316710673e-11 10.948574042409122 -0.2612713438741673 LTLAK(ub)EGSPFLTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTLAKEGSPFLTQK 14 1 Q8N531-2;Q8N531 Q8N531-2 FBXL6 F-box/LRR-repeat protein 6 1 14357800.0 7409300.0 6948500.0 0.0 True False 9713664.051763263 5911810.88504086 0.0 1.0 0.6086077152285007 0.0 23.211584160767522 -7.630632314129142 0.6680632230585933 0.9975669490831173 1.836651152597429e-21 0.9872071328689747 0.04653684371141938 0.12115495837829807 0.1479468376118918 0.042464449955475284 0.0774245859045006 2.3408182022163612e-08 7.630632314129142 -0.9975669490831173 down LTLAK(ub)EGSPFLTQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTLAKEGSPFLTQK 14 1 Q8N531-2;Q8N531 Q8N531-2 FBXL6 F-box/LRR-repeat protein 6 1 22176500.0 7777900.0 5332700.0 9065900.0 True False 7530994.821907201 7462074.919663129 6691268.818829818 1.0 0.9908484995842 0.8884973336278665 22.844409022512675 -6.924434406462323 0.7911345166105263 1.0019182473088541 0.8701821032066642 0.9953268342906615 0.0034552181121975827 0.0956323971208966 0.09260237428866082 0.0030492236004956846 0.009560022139673724 1.190051054593767e-07 6.924434406462323 -0.13173614410218992 LTLAK(ub)EGSPFLTQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTLAKEGSPFLTQK 14 1 Q8N531-2;Q8N531 Q8N531-2 FBXL6 F-box/LRR-repeat protein 6 1 69535000.0 16627000.0 16726000.0 36182000.0 True False 25224374.59652265 13741114.619165534 29030611.84086605 1.0 0.5447554137203401 1.1508952077197632 24.58831516435861 -6.70572479630121 1.8103393694438796 0.7189131192401715 1.1493057298512859 0.4448230972288306 0.19197081479376396 0.3837362099782578 2.4487422702743618 0.08447163820061544 0.2157260012784396 1.96913369494785e-07 6.70572479630121 0.43039261061111433 LTLAK(ub)EGSPFLTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTLAKEGSPFLTQK 14 1 Q8N531-2;Q8N531 Q8N531-2 FBXL6 F-box/LRR-repeat protein 6 1 24170900.0 7409300.0 9314400.0 7447200.0 True False 10148718.438803732 8902859.00939819 5688324.739898448 1.0 0.87723972864968 0.560496852306896 23.274794222290414 -6.954781925820012 0.5036223133795397 1.0061490199070935 0.41784181518143254 0.999525061357 0.004035211194989113 0.08162056381707372 0.028441699817695544 0.004700637577735317 0.026132163554511388 1.1097319099004347e-07 6.954781925820012 -0.588307204725661 LTLAK(ub)EGSPFLTQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTLAKEGSPFLTQK 14 1 Q8N531-2;Q8N531 Q8N531-2 FBXL6 F-box/LRR-repeat protein 6 1 25845800.0 7777900.0 9465100.0 8602800.0 True False 6467668.469392973 9414109.62762475 10401605.70514699 1.0 1.4555646555130735 1.608246581340809 22.62481429794695 -11.713686000112734 0.18964033082381848 1.5261808523584562e-11 1.7334224588107745 0.9994282555624907 0.006178027705183463 4.58928558189041 0.11707904970257528 1.9539051123970606 0.10404017958066218 1.933365657335412e-12 11.713686000112734 1.7334224587955127 LTLAK(ub)EGSPFLTQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTLAKEGSPFLTQK 14 1 Q8N531-2;Q8N531 Q8N531-2 FBXL6 F-box/LRR-repeat protein 6 1 99144000.0 16627000.0 16408000.0 66109000.0 True False 21523979.267169137 15494880.37620881 54077840.335622184 1.0 0.7198892074684069 2.5124462193711534 24.35944148645106 -6.866962492350563 1.149955364387835 0.8441283320545873 2.611578928761224 0.9615611690199116 0.1543655656283128 0.13980534506435213 0.3474269782672467 0.10435338457542431 0.24585492547870821 1.3584307617886595e-07 6.866962492350563 1.7674505967066367 up LTLDKLDVKGK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTLDKLDVKGK 11 2 P00558 P00558 PGK1 Phosphoglycerate kinase 1 1 8788900.0 2035900.0 3919000.0 2834000.0 True False 2635512.6835887237 3700904.2049221336 2318241.0792956064 1.0 1.404244505430605 0.8796167416424288 21.329652204478897 -6.700853520883228 1.8273970099520587 1.2507963149115915 0.8811275783774026 0.4218901718628595 0.17060829414813392 0.393715168714149 2.556580689551074 0.0744582389893834 0.19131592619695587 1.9913448677869703e-07 6.700853520883228 -0.36966873653418886 LTLDLMK(ub)PK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LTLDLMKPK 9 1 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 262583400.0 122152600.0 72935900.0 67494900.0 True False 160143241.527461 62054148.021911465 60511175.20479776 1.0 0.3874915196547371 0.3778565653326147 27.254787672912027 LTLDLMK(ub)PK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LTLDLMKPK 9 1 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 230979000.0 79357600.0 81214500.0 70406900.0 True False 76838436.42615403 113643873.37802258 51965220.72827518 1.0 1.4789977342555714 0.6762920114624745 26.19532482632814 -6.74512509373894 1.6684275886856867 1.2833058788393774 0.6753219358326031 0.6275139956957922 0.20124631452327507 0.3086214019197846 1.6887505339469646 0.09536043426018596 0.232657677944004 1.798352844803728e-07 6.74512509373894 -0.6079839430067743 LTLDLMK(ub)PK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LTLDLMKPK 9 1 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 509346200.0 325360500.0 158712600.0 25273100.0 True False 493595665.5386966 130389096.50279635 20277860.707406737 1.0 0.26416175344751724 0.04108192620629284 28.87875448475867 -9.616288281118214 0.35418117225008583 1.3230717522621616 3.673757254531762e-20 0.9983236934596188 0.016774563358595555 1.0132192437410468 0.15524432141354824 0.44720680727135 0.06445841647109972 2.419422520752721e-10 9.616288281118214 -1.3230717522621616 LTLDLMK(ub)PK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LTLDLMKPK 9 1 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 282210570.0 122152600.0 107699470.0 52358500.0 True False 167315717.26989278 102940951.30087927 39992500.657156035 1.0 0.6152497385217421 0.23902417124773243 27.31799773443492 -7.582207303043401 0.3275933077649698 1.0748142086076244 1.6494823007251697e-12 0.9994467196959719 0.007307634037118175 0.12471519680673927 0.04037496902489846 0.025483100487640138 0.07058991318480773 2.6169335615622896e-08 7.582207303043401 -1.0748142086059749 down LTLDLMK(ub)PK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LTLDLMKPK 9 1 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 307138500.0 79357600.0 199537400.0 28243500.0 True False 65989360.53776729 198462452.42112726 34149085.26681064 1.0 3.007491674472924 0.5174938048879304 25.975730101762416 -6.692144836837648 1.8587881457077196 2.2560358061057637 0.5258736392794351 0.38047435518336525 0.8486623469021297 0.41208219909968175 2.7621016000789664 0.3650224230821317 0.9479842129135226 2.0316793346227422e-07 6.692144836837648 -1.7301621668263287 LTLDLMK(ub)PK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LTLDLMKPK 9 1 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 514849800.0 325360500.0 175873700.0 13615600.0 True False 421185581.06428 166086173.98959243 11137700.507853672 1.0 0.39433015149738687 0.026443688978407532 28.64988080685112 -8.383816556708942 0.4764291161176794 1.0549268512694285 1.7296363955618418e-16 0.994553573531998 0.029622165849553513 0.16380951597183346 0.15210074862668366 0.07178227424168565 0.07293486988165056 4.132220075413393e-09 8.383816556708942 -1.0549268512694283 LTLDLMK(ub)PKSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTLDLMKPKSR 11 2 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 62647000.0 20922000.0 27825000.0 13900000.0 True False 27428944.608936198 23673618.461000524 12461761.338215047 1.0 0.8630889302714109 0.4543288674021776 24.70919577649082 -6.951559539897666 0.5414596487354743 1.005960906639163 0.2925333282152858 0.9993180067978383 0.006053487037936315 0.08286564160323613 0.03341801780847738 0.006644880441490243 0.03385905014894063 1.1179965415802364e-07 6.951559539897666 -0.7134275784238773 down LTLDLMK(ub)PKSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTLDLMKPKSR 11 2 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 80496000.0 19862000.0 32422000.0 28212000.0 True False 19231491.681909144 45368273.67849638 20822430.85814173 1.0 2.35906160733095 1.0827257293686254 24.196967333214342 -6.631383904041416 2.0757106138999664 1.8944755502264994 1.0879137631218456 0.12242776946754452 0.5827633882213245 0.5553842050720112 4.562043960251459 0.22949918886277326 0.6454182008361848 2.3367706861974395e-07 6.631383904041416 -0.8065617871046538 LTLDLMK(ub)PKSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTLDLMKPKSR 11 2 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 58686000.0 20922000.0 14139000.0 23625000.0 True False 28657428.795790654 13514292.228579491 18045261.572148014 1.0 0.4715807661908782 0.6296887868320759 24.77240583801371 -10.836710098275496 10.882749139330391 1.0075085559584547 0.5506347765114984 0.9150407648141757 0.06454732913539411 0.011546931711713108 0.00017325527447120426 0.061369844211244313 0.020832560898629178 1.4564309578997205e-11 10.836710098275496 -0.4568737794469563 LTLDLMK(ub)PKSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTLDLMKPKSR 11 2 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 69366800.0 19862000.0 40269000.0 9235800.0 True False 16516133.035791602 40052062.904229306 11166963.078485658 1.0 2.4250266583245432 0.6761245537491177 23.97737260864862 -6.690027714479202 1.8661469235860841 1.8933644671352206 0.6821354225071825 0.37064837495220904 0.6026803771063873 0.4165990983098747 2.812842390086739 0.2583473655851465 0.672773251504513 2.0416076554287206e-07 6.690027714479202 -1.211229044628038 LTLDLMK(ub)PKSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTLDLMKPKSR 11 2 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 99692000.0 44822000.0 40846000.0 14024000.0 True False 58022962.57370875 38572884.19348035 11471775.898391536 1.0 0.66478653420152 0.19771096458265996 25.79012062367853 -7.355787305205898 0.4275606695744748 1.025835632118522 3.521979951885938e-25 0.9991029369058784 0.009854014392218096 0.10754981109643333 0.04091676328022239 0.014133357324380286 0.05748539520933402 4.407706771519844e-08 7.355787305205898 -1.025835632118522 down LTLDLMKPK(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTLDLMKPKSR 11 2 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 9114300.0 3488300.0 3375100.0 2250900.0 True False 4573195.080745249 2871548.2360367603 2017998.4601574244 1.0 0.6279085377588598 0.4412666471749486 22.124771031443217 -13.379335538428919 0.09510389801638106 2.6831338816516435 1.4347304520110292e-18 0.9998378203103364 0.0029577226268104185 9.77904537438056 0.08437867695404624 3.4558760995450815 0.3745029941951465 4.175076731618664e-14 13.379335538428919 -2.6831338816516435 LTLDLMKPK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTLDLMKPKSR 11 2 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 17708300.0 7745300.0 4894300.0 5068700.0 True False 7499429.691062881 6848619.51343733 3741055.412259428 1.0 0.913218710697278 0.49884532109390506 22.838349456511413 -6.940837816054428 0.6517223617813538 1.0045923748666967 0.3842928848973271 0.9982715943226321 0.009091462498558306 0.08738647837862545 0.05288457125035155 0.008907079111468624 0.03553469107220521 1.1459408043597078e-07 6.940837816054428 -0.6202994899693697 down LTLDLMKPK(ub)SR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTLDLMKPKSR 11 2 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 9339800.0 3488300.0 3452400.0 2399100.0 True False 4778018.777762953 3299861.5524399057 1832481.991015465 1.0 0.6906338601676417 0.3835233966730924 22.18798109296611 -7.126879700547971 0.2446812791843933 1.1126854486084532 7.978296807966764e-14 0.9999805186884821 0.0011108237902652048 0.07965963741845507 0.010051292217144061 0.009236842489218008 0.032776433764812284 7.466555531505461e-08 7.126879700547971 -1.1126854486083735 down LTLDLMKPK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTLDLMKPKSR 11 2 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 19140600.0 7745300.0 9121600.0 2273700.0 True False 6440560.124968116 9072460.130304152 2749120.1575990007 1.0 1.408644582810888 0.4268448868199348 22.61875473194569 -6.793662704490705 1.4817416835337693 1.2273056774100997 0.41533201303388523 0.8129647333525384 0.17415333970475036 0.22992605506433442 0.9971665327315594 0.09249552268145235 0.21598435734547072 1.608189771295945e-07 6.793662704490705 -0.8119736643762144 down LTLDLMKPK(ub)SR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTLDLMKPKSR 11 2 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 26180400.0 13831000.0 9528600.0 2820800.0 True False 17904502.14976943 8998325.033687415 2307443.3438521684 1.0 0.5025733169466147 0.12887503514761975 24.093819068039235 -8.099114815775547 0.37308983455251166 1.0810777155195448 6.395230845581914e-22 0.9978938505202106 0.016375882409881342 0.09438328447968086 0.08532407788292388 0.057437384702358076 0.08492661030271009 7.959488951277408e-09 8.099114815775547 -1.0810777155195448 down LTLFVNGQPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTLFVNGQPR 10 0 Q92734-2;Q92734;Q92734-4;Q92734-3;C9JJP5;C9JTY3;C9JUE0 Q92734-2 TFG Protein TFG 0 38602000.0 11997000.0 10819000.0 15786000.0 False True 15728183.179113276 9204847.372131698 14152616.150004504 1.0 0.5852454328199558 0.8998252365727089 23.906848693524246 -9.75694272426476 5.90765170429455 1.0000000116726164 0.742535334695097 0.47177291061885307 0.12842666710090667 1.975061322707005e-08 4.077457767602103e-09 0.12434859127957114 0.04144952857358643 1.7500774775685227e-10 9.75694272426476 -0.2574646769775194 LTLFVNGQPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTLFVNGQPR 10 0 Q92734-2;Q92734;Q92734-4;Q92734-3;C9JJP5;C9JTY3;C9JUE0 Q92734-2 TFG Protein TFG 0 41342700.0 15666000.0 6007700.0 19669000.0 False True 15168691.405134857 8406605.93974163 14517098.84264814 1.0 0.5542077240028663 0.9570435876712382 23.85459329463799 -10.363132476243665 8.47803761539468 1.0000009742463487 0.7556256558370523 0.32916284482682345 0.1644570526801466 3.0283019605864706e-06 2.2753956150468963e-07 0.1592354900266711 0.05307828551638031 4.333786613392004e-11 10.363132476243665 -0.24437531840929638 LTLFVNGQPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTLFVNGQPR 10 0 Q92734-2;Q92734;Q92734-4;Q92734-3;C9JJP5;C9JTY3;C9JUE0 Q92734-2 TFG Protein TFG 0 40559400.0 11997000.0 7818400.0 20744000.0 False True 16432615.106734581 7472957.236008634 15844694.436090533 1.0 0.45476372369641826 0.9642223306013478 23.970058755047138 -10.626971358350936 9.602979965993823 1.0000760273737044 0.7094930271488832 0.30242853111576695 0.20798560533103866 0.00033862893037794916 1.3153830032051393e-05 0.20143333113550554 0.06712706547483177 2.3606339114620488e-11 10.626971358350936 -0.2905830002248212 LTLFVNGQPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTLFVNGQPR 10 0 Q92734-2;Q92734;Q92734-4;Q92734-3;C9JJP5;C9JTY3;C9JUE0 Q92734-2 TFG Protein TFG 0 30427000.0 15666000.0 5693100.0 9067900.0 False True 13026973.121473722 5662430.140308129 10963955.964767542 1.0 0.43466967249469124 0.8416349571409268 23.634998570072266 -10.016666054668296 6.986603550086017 1.0000000487934317 0.6381523148178087 0.5131652131127487 0.1661428817349663 1.2623706299383247e-07 1.766968230614332e-08 0.1608671762850293 0.05362238450420254 9.623519825226892e-11 10.016666054668296 -0.3618477339756231 LTLFVNGQPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTLFVNGQPR 10 0 Q92734-2;Q92734;Q92734-4;Q92734-3;C9JJP5;C9JTY3;C9JUE0 Q92734-2 TFG Protein TFG 0 22870200.0 9312800.0 6950100.0 6607300.0 False True 12055603.182732463 6563320.825371094 5404839.196623097 1.0 0.5444207747955656 0.4483259041210465 23.523200499885842 -13.999999999999998 0.21873075787818308 3.7339630507202357 0.39629521832443826 0.9994966528548718 0.005398657059859593 12.965430463887495 0.1481705214479688 15.300619844259456 0.053630093876724384 1.0000000000000041e-14 13.999999999999998 -3.3376678323957973 LTLGINVTSIAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTLGINVTSIAVR 13 0 Q9HCI7-2;Q9HCI7 Q9HCI7-2 MSL2 E3 ubiquitin-protein ligase MSL2 0 13875300.0 3444100.0 4504600.0 5926600.0 False True 5224951.497436925 3700718.9353995626 4755204.912278944 1.0 0.7082781413789071 0.910095512773963 22.31698621422449 -10.07769139322746 5.232074885175113 1.000002851153772 0.8091868278004117 0.5437739678062337 0.08239159685899139 2.7402475963182336e-06 4.83048751182405e-07 0.07977651285463558 0.02659177354170793 8.361970031985178e-11 10.07769139322746 -0.19081602335336023 LTLGINVTSIAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTLGINVTSIAVR 13 0 Q9HCI7-2;Q9HCI7 Q9HCI7-2 MSL2 E3 ubiquitin-protein ligase MSL2 0 8731700.0 3444100.0 3510600.0 1777000.0 False True 4458455.343360635 3315232.0239345822 1453604.233559737 1.0 0.7435830951792534 0.3260331486160089 22.088112536316938 -6.963856353262578 0.3771655042825345 1.0296115802001615 0.025305216077297202 0.9998875943515529 0.002944791837419612 0.07835122325977567 0.016241658457547565 0.005450936799558698 0.03533135220222465 1.0867850279267986e-07 6.963856353262578 -1.0043063641228642 down LTLHGLQQYYVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTLHGLQQYYVK 12 0 O00148;O00148-2;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;A0A140T996;A0A140T9X9;H0Y400;F6UJC5;A0A140TA18;H0YCC6 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 215031400.0 66928500.0 89639600.0 58463300.0 False True 87743911.63651589 76265721.092424 52414078.53557318 1.0 0.8691853334321253 0.5973528824735038 26.386795687559925 -6.959289640399619 0.44533162003404225 1.0091965860724539 0.44664889264046875 0.9997429395104592 0.002688854302168317 0.07995585410225398 0.0220762725813332 0.003609080719760974 0.02250161140651869 1.0982731329826647e-07 6.959289640399619 -0.5625476934319851 LTLHGLQQYYVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTLHGLQQYYVK 12 0 O00148;O00148-2;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;A0A140T996;A0A140T9X9;H0Y400;F6UJC5;A0A140TA18;H0YCC6 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 227038700.0 68641200.0 46745600.0 111651900.0 False True 66462222.67829324 65411361.85508365 82406917.90479772 1.0 0.9841885994650491 1.2399061389156951 25.986031205711704 -6.8921819011017424 1.009418566645373 0.9869699956296007 1.2628612064176505 0.9822573694290727 0.015584280540095048 0.11738943784639634 0.21166527870699778 0.011728981589750515 0.029478897795153322 1.2817936002322417e-07 6.8921819011017424 0.2758912107880498 LTLHGLQQYYVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTLHGLQQYYVK 12 0 O00148;O00148-2;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;A0A140T996;A0A140T9X9;H0Y400;F6UJC5;A0A140TA18;H0YCC6 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 198900300.0 42792300.0 76637000.0 79471000.0 False True 64919047.63618073 62960528.58238604 63763522.016623355 1.0 0.9698313649828842 0.9822005149238607 25.95213849988551 -10.000117041304135 5.743518697083253 1.0000000433587015 0.9760159399862343 0.8336956308079578 0.005049684317926706 2.8013205433233527e-09 4.94718456327745e-10 0.004889344632405026 0.0016297786055732603 9.997305387490409e-11 10.000117041304135 -0.023984103372467258 LTLHGLQQYYVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTLHGLQQYYVK 12 0 O00148;O00148-2;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;A0A140T996;A0A140T9X9;H0Y400;F6UJC5;A0A140TA18;H0YCC6 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 227925200.0 66928500.0 80284800.0 80711900.0 False True 91673775.1247048 76737552.06966965 61649411.53375888 1.0 0.8370720194001257 0.672486885697644 26.450005749082816 -6.970999591966249 0.23308244737441727 1.0644076329585517 0.4404310826397596 0.9999891611265597 0.0004401590526363515 0.07597971322175814 0.00786017296324468 0.004134535098557895 0.016250325591464148 1.0690558836348601e-07 6.970999591966249 -0.6239765503187921 LTLHGLQQYYVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTLHGLQQYYVK 12 0 O00148;O00148-2;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;A0A140T996;A0A140T9X9;H0Y400;F6UJC5;A0A140TA18;H0YCC6 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 123051300.0 42792300.0 16471000.0 63788000.0 False True 55395475.91234031 15554374.370827362 52179238.52015104 1.0 0.2807878100991701 0.9419404321522798 25.72326482197796 -10.842400363547524 10.224242419103458 1.0095105581201502 0.6113641211257695 0.3153981491637021 0.2699144276888826 0.057086131162967825 0.0008799416761409733 0.254962903580975 0.08711450694501237 1.437472802566654e-11 10.842400363547524 -0.3981464369943807 LTLHGLQQYYVK(ub)LK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTLHGLQQYYVKLK 14 1 O00148;O00148-2;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;A0A140T996;A0A140T9X9;H0Y400;F6UJC5;A0A140TA18;H0YCC6 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 1 34309600.0 10908800.0 11551400.0 11849400.0 True False 14942078.15923531 11041020.952628432 9050815.766053356 1.0 0.7389213759268328 0.6057267047863274 23.832877477768434 -13.999999998797659 0.08636621766109258 2.359536910110251 0.25090605336266636 0.999859130424726 0.001943627128440626 12.196978163224761 0.08447755759785193 3.0846964666527645 0.3199155247400034 1.0000000027684933e-14 13.999999998797659 -2.1086308567475847 LTLHQSIHTGEKPFECKECR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTLHQSIHTGEKPFECKECR 20 2 Q8N141 Q8N141 ZFP82 Zinc finger protein 82 homolog 0 13868100.0 3170600.0 4778800.0 5918700.0 False True 4156687.3041340723 4065821.6676165024 5306289.70017938 1.0 0.9781398912477254 1.2765669659350993 21.98700279148827 -6.889273351012708 1.026647380598833 0.9836847608687213 1.3018743172670573 0.9804299754358339 0.01900038028347848 0.11973569359141667 0.22529529607662513 0.014114499488980442 0.035097689113637594 1.290406817880556e-07 6.889273351012708 0.318189556398336 LTLHQSIHTGEKPFECKECR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTLHQSIHTGEKPFECKECR 20 2 Q8N141 Q8N141 ZFP82 Zinc finger protein 82 homolog 0 19346700.0 6443800.0 5751600.0 7151300.0 False True 6239245.096157787 8048243.874197762 5278159.995598649 1.0 1.2899387265863271 0.845961316513918 22.572940053233292 -6.730496388164064 1.7215558313657098 1.1743860515742113 0.8462071941224605 0.5615451468086063 0.12187814192890939 0.335288684072261 1.9470294561979995 0.05609914486435198 0.1391208517920344 1.8599600316266818e-07 6.730496388164064 -0.3281788574517508 LTLHQSIHTGEKPFECKECR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTLHQSIHTGEKPFECKECR 20 2 Q8N141 Q8N141 ZFP82 Zinc finger protein 82 homolog 0 42046300.0 10627000.0 24617000.0 6802300.0 False True 16121935.937766662 20223904.01650111 5457822.423445999 1.0 1.254433964665827 0.3385339356584777 23.942521658705058 -6.8325811591946275 1.316255430871609 1.1357293233542605 0.3125475389202444 0.9109570008494293 0.1151905370455067 0.17764425581005408 0.6009940724692797 0.0686919478096108 0.15808578790453098 1.470343617865907e-07 6.8325811591946275 -0.8231817844340161 down LTLHQSIHTGEKPFECKECR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTLHQSIHTGEKPFECKECR 20 2 Q8N141 Q8N141 ZFP82 Zinc finger protein 82 homolog 0 13623100.0 3170600.0 4609900.0 5842600.0 False True 4342856.502243275 4406219.375099272 4462698.212124109 1.0 1.0145901373492923 1.027595134635218 22.05021285301116 -6.972484118775773 0.18965748952219033 0.9911463904405368 1.0513940438556524 0.9999955731906384 2.3002485705442294e-05 0.0755045670033333 0.006048024748290907 0.00046047783807000455 0.0014190401696407117 1.0654078226501656e-07 6.972484118775773 0.06024765341511562 LTLHQSIHTGEKPFECKECR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTLHQSIHTGEKPFECKECR 20 2 Q8N141 Q8N141 ZFP82 Zinc finger protein 82 homolog 0 22055700.0 6443800.0 10364000.0 5247900.0 False True 5358305.208742009 10308167.074907064 6345211.626451945 1.0 1.9237737816967606 1.1841825687905592 22.35334532866757 -10.229066878936697 4.74830533948832 0.9998789869650551 1.553978175245241 0.4279395836340958 0.30193684831694323 212859932.92730224 60.65770211815116 281653.4986197167 0.1033610142273694 5.901101994831776e-11 10.229066878936697 0.554099188280186 LTLHVGDGFEFMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTLHVGDGFEFMK 13 0 P19623;K7EQ47 P19623 SRM Spermidine synthase 0 9316500.0 4457200.0 2812900.0 2046400.0 False True 5843432.363586202 2393226.2845983193 1834658.1584549106 1.0 0.40955831019999356 0.31396926400444436 22.478384609544033 -13.999999999999998 0.25624891137682426 5.239104164714625 0.27775615947804266 0.9995547778597409 0.0064015649803870825 14.254517451062517 0.1601813674677396 31.220115527772894 0.042632548846322095 1.0000000000000041e-14 13.999999999999998 -4.961348005236583 LTLHVGDGFEFMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LTLHVGDGFEFMK 13 0 P19623;K7EQ47 P19623 SRM Spermidine synthase 0 81824800.0 41576500.0 16496900.0 23751400.0 False True 40256676.7653255 23084198.200197008 17530195.81327334 1.0 0.5734253310268334 0.4354605800042769 25.262724745261863 -13.999999999999998 0.15787754530968132 3.0916725918759878 0.296607363161014 0.9995421125969501 0.00514204955484333 11.9962115765033 0.12548963307469246 7.685280698208322 0.12622380169358616 1.0000000000000041e-14 13.999999999999998 -2.7950652287149738 LTLHVGDGFEFMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LTLHVGDGFEFMK 13 0 P19623;K7EQ47 P19623 SRM Spermidine synthase 0 236743200.0 60332200.0 99251000.0 77160000.0 False True 91528358.27463311 81538883.59839766 61909292.17957064 1.0 0.8908592389884041 0.6763946534888157 26.447715467756648 -6.960388400507366 0.4299248701659157 1.0085256522544879 0.5505048930256602 0.9997843325273017 0.001974084708431215 0.07956266752945464 0.020620811341344743 0.002796364091651916 0.017807507971368215 1.0954980264015678e-07 6.960388400507366 -0.4580207592288277 LTLHVGDGFEFMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTLHVGDGFEFMK 13 0 P19623;K7EQ47 P19623 SRM Spermidine synthase 0 21500800.0 4457200.0 5236600.0 11807000.0 False True 6105147.2913009375 5005229.6968795145 9018429.772797946 1.0 0.8198376645247091 1.4771846349469844 22.541594671066925 -6.8336572333870995 1.3115514140946438 0.9039514755447746 1.4962240503570505 0.9129822929043397 0.08181254533611512 0.1763410182223467 0.5919497562081142 0.04895825651080264 0.11266798652369411 1.4667049801291673e-07 6.8336572333870995 0.5922725748122759 LTLHVGDGFEFMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LTLHVGDGFEFMK 13 0 P19623;K7EQ47 P19623 SRM Spermidine synthase 0 74730090.0 41576500.0 11551290.0 21602300.0 False True 34572701.90124807 11489060.90801846 26119241.052250057 1.0 0.3323159682698594 0.7554874110463191 25.04313002069614 -10.305849477326014 5.877053207185462 1.0000379750983976 0.5439016896584553 0.607673667294448 0.17275901808662134 8.59681618149326e-05 1.0153803912552041e-05 0.16728708184942062 0.05575773332971844 4.944820404463698e-11 10.305849477326014 -0.45613628543994233 LTLHVGDGFEFMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LTLHVGDGFEFMK 13 0 P19623;K7EQ47 P19623 SRM Spermidine synthase 0 168900000.0 60332200.0 64205500.0 44362300.0 False True 78101222.22545873 60632407.4838295 36288816.59563713 1.0 0.7763310964430092 0.4646382676429874 26.218841789849098 -6.966451681472248 0.332195949241709 1.0370148186417554 0.19371726308939763 0.9999400170887229 0.0017003212116510214 0.0774717356251663 0.013141466017315084 0.004513193087442192 0.027138961014688948 1.0803098067877643e-07 6.966451681472248 -0.8432975555523577 down LTLK(ub)GGAAVDPDSGLEHSAHVLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTLKGGAAVDPDSGLEHSAHVLEK 24 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 19364700.0 7134900.0 7248700.0 4981100.0 True False 6908406.5049468 10143143.711471139 3676400.480203096 1.0 1.468232030672788 0.5321633111153188 22.719921545852877 -6.770710777145255 1.5717131167944376 1.2683287207803882 0.5267578666332796 0.7332401233235837 0.1973751051177495 0.26530329613310105 1.2934988619868804 0.09897803021060972 0.23545737754548413 1.6954665378505972e-07 6.770710777145255 -0.7415708541471085 LTLK(ub)GGAAVDPDSGLEHSAHVLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTLKGGAAVDPDSGLEHSAHVLEK 24 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 10878200.0 2051300.0 5006800.0 3820100.0 True False 2809721.0442981254 4785583.020726492 2917871.0574291106 1.0 1.7032235390193124 1.0384913702911747 21.42199547272943 -10.467435121315441 5.288493406727273 0.9994340980929465 1.370857454655247 0.2932915994745763 0.2713757714996119 0.0018133738073674711 0.00018261153412824833 0.26314682530010636 0.0875861536318469 3.4085124031809875e-11 10.467435121315441 0.3714233565623005 LTLK(ub)GGAAVDPDSGLEHSAHVLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTLKGGAAVDPDSGLEHSAHVLEK 24 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 20564800.0 7134900.0 9944800.0 3485100.0 True False 5932985.479663141 9891225.388511764 4213818.29671825 1.0 1.6671581992601405 0.7102357339592713 22.500326821287153 -6.7192501224251835 1.7621533369463436 1.406216232386991 0.7118033945093404 0.508931758758526 0.28076833372732235 0.3567671516657484 2.1646816940811533 0.12653628543628836 0.3179171354444301 1.9087536369604727e-07 6.7192501224251835 -0.6944128378776505 LTLK(ub)GGAAVDPDSGLEHSAHVLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTLKGGAAVDPDSGLEHSAHVLEK 24 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 37571000.0 11096000.0 10965000.0 15510000.0 True False 14363990.734859502 10354788.11099035 12687339.146039126 1.0 0.7208851844954655 0.8832739717137686 23.775953291751936 -10.21649671837319 5.214580105522367 1.0000162498516108 0.8020795784454676 0.6645027781464773 0.06629494477259583 1.2525302197034011e-05 1.8819184876529427e-06 0.06419507198360198 0.02139660142013483 6.07439852798428e-11 10.21649671837319 -0.19793667140614313 LTLK(ub)GTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTLKGTQK 8 1 A0A1W2PQS3;A0A1W2PNV3;A0A1W2PS12;A0A1W2PRL0;A0A1W2PPG5;A0A1W2PPP5;I3L4Z6;A0A1W2PPG1;A0A1W2PRC2;A0A1W2PQP2;A0A1W2PQM3;A0A1W2PS81;E7EQ34;I3NI02;O14653;O14653-2 A0A1W2PQS3 GOSR2 Golgi SNAP receptor complex member 2 1 5654590.0 2035700.0 2660400.0 958490.0 True False 2668822.4137468394 2263478.6901579783 859314.6492853047 1.0 0.8481188851303947 0.3219827010066538 21.347771879550933 -6.9481808740045 0.5784761419105025 1.0063256853229485 0.13782066871382476 0.9990506387401393 0.008951284209514503 0.08422467020455633 0.039050567145259216 0.00939413961140468 0.043933001093313655 1.1267281012187875e-07 6.9481808740045 -0.8685050166091237 down LTLK(ub)GTQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTLKGTQK 8 1 A0A1W2PQS3;A0A1W2PNV3;A0A1W2PS12;A0A1W2PRL0;A0A1W2PPG5;A0A1W2PPP5;I3L4Z6;A0A1W2PPG1;A0A1W2PRC2;A0A1W2PQP2;A0A1W2PQM3;A0A1W2PS81;E7EQ34;I3NI02;O14653;O14653-2 A0A1W2PQS3 GOSR2 Golgi SNAP receptor complex member 2 1 6718100.0 2575800.0 2939200.0 1203100.0 True False 2494032.638921638 4112837.887725513 887972.0177736528 1.0 1.6490713968778727 0.35603865158620834 21.25004891488561 -6.770216975575679 1.5735549197925467 1.3721823833812339 0.348693179100355 0.7314283764917668 0.2735678710718184 0.26607138605582503 1.3002081406677986 0.13703163023444165 0.32613631944303995 1.6973954138165617e-07 6.770216975575679 -1.023489204280879 LTLK(ub)GTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTLKGTQK 8 1 A0A1W2PQS3;A0A1W2PNV3;A0A1W2PS12;A0A1W2PRL0;A0A1W2PPG5;A0A1W2PPP5;I3L4Z6;A0A1W2PPG1;A0A1W2PRC2;A0A1W2PQP2;A0A1W2PQM3;A0A1W2PS81;E7EQ34;I3NI02;O14653;O14653-2 A0A1W2PQS3 GOSR2 Golgi SNAP receptor complex member 2 1 4635550.0 2035700.0 1756600.0 843250.0 True False 2788353.3027239745 1678987.603700599 644091.7172788916 1.0 0.6021430648908 0.23099358200041256 21.410981941073825 -7.659140728579111 0.32444650404013725 1.0812793496557656 6.369791743958891e-13 0.9993631227732452 0.007924454408285807 0.12436249801694065 0.04439665178092847 0.030095736499370307 0.07498780236172081 2.192094494984881e-08 7.659140728579111 -1.0812793496551285 down LTLK(ub)GTQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTLKGTQK 8 1 A0A1W2PQS3;A0A1W2PNV3;A0A1W2PS12;A0A1W2PRL0;A0A1W2PPG5;A0A1W2PPP5;I3L4Z6;A0A1W2PPG1;A0A1W2PRC2;A0A1W2PQP2;A0A1W2PQM3;A0A1W2PS81;E7EQ34;I3NI02;O14653;O14653-2 A0A1W2PQS3 GOSR2 Golgi SNAP receptor complex member 2 1 6306550.0 2575800.0 3179500.0 551250.0 True False 2141891.8272878868 3162371.4024186647 666513.826307978 1.0 1.47643842799612 0.3111799661479326 21.030454190319887 -6.7956754457036235 1.4734267496768603 1.2643235259736014 0.29674406698589284 0.8192608593206104 0.20335929047861218 0.22697588191386714 0.9732062461913168 0.10860120125927623 0.25326919702328027 1.6007538473091458e-07 6.7956754457036235 -0.9675794589877086 down LTLLPAVVMHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTLLPAVVMHLK 12 0 Q96ST2-2;Q96ST2-3;Q96ST2 Q96ST2-2 IWS1 Protein IWS1 homolog 0 6665300.0 1514800.0 3101400.0 2049100.0 False True 1985917.4693440655 2638683.209162511 1837078.7883551398 1.0 1.3286973149161376 0.9250529373518799 20.921374237990015 -6.690192155286297 1.866118026914087 1.2060373624000982 0.926458280638829 0.371211599153659 0.13901046397072025 0.4162213633167239 2.810474665306933 0.059594565314309796 0.155128798368082 2.040834769579093e-07 6.690192155286297 -0.2795790817612692 LTLLPAVVMHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTLLPAVVMHLK 12 0 Q96ST2-2;Q96ST2-3;Q96ST2 Q96ST2-2 IWS1 Protein IWS1 homolog 0 22063000.0 0.0 11919000.0 10144000.0 False True 0.0 9791961.326427946 8139033.953726847 0.0 LTLLPAVVMHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTLLPAVVMHLK 12 0 Q96ST2-2;Q96ST2-3;Q96ST2 Q96ST2-2 IWS1 Protein IWS1 homolog 0 20647110.0 1514800.0 8284310.0 10848000.0 False True 2074862.4959307748 7918281.791650286 8285925.821572985 1.0 3.8162923119867647 3.99348189955882 20.984584299512907 -10.204653557594416 0.5943896872481943 1.6779524161760677e-19 3.973914070553867 0.9996804373707155 0.024513542936364586 1.5012759277639154 0.28521408810081067 2.587196894943597 0.03095329902150817 6.242325954516943e-11 10.204653557594416 3.973914070553867 LTLLPAVVMHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTLLPAVVMHLK 12 0 Q96ST2-2;Q96ST2-3;Q96ST2 Q96ST2-2 IWS1 Protein IWS1 homolog 0 8602800.0 5924700.0 2678100.0 0.0 False True 4926650.558712834 2663672.543738774 0.0 1.0 0.5406660188285611 0.0 22.232175716011703 -7.808547875924908 0.6190316774385487 1.0048418566198556 2.932370546707229e-19 0.988116463732834 0.04455285039941934 0.11654192959989447 0.15612742937879168 0.04346860252164412 0.0778237581307019 1.5540039704314025e-08 7.808547875924908 -1.0048418566198556 down LTLLPAVVMHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTLLPAVVMHLK 12 0 Q96ST2-2;Q96ST2-3;Q96ST2 Q96ST2-2 IWS1 Protein IWS1 homolog 0 19294400.0 0.0 10135000.0 9159400.0 False True 0.0 9570978.340618985 7492483.18338044 0.0 LTLLQVASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTLLQVASR 9 0 O95239-2;O95239 O95239-2 KIF4A Chromosome-associated kinesin KIF4A 0 11474500.0 3604800.0 3350000.0 4519700.0 False True 4725927.70893286 2850193.058197721 4052044.8000237755 1.0 0.6030970496671668 0.8574072752667538 22.172166130341026 -10.090953485578588 4.9947467963367105 1.0000077714276139 0.730252162465817 0.6000197689807052 0.10382171485247448 8.984923490301415e-06 1.6354639828881035e-06 0.10052783789863606 0.033508314382627045 8.110479192027236e-11 10.090953485578588 -0.26975560896179684 LTLLQVASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTLLQVASR 9 0 O95239-2;O95239 O95239-2 KIF4A Chromosome-associated kinesin KIF4A 0 8934500.0 3097900.0 1751400.0 4085200.0 False True 2999558.860204728 2450743.1534303455 3015163.566626988 1.0 0.817034526624717 1.0052023337929081 21.516318911047993 -11.063174119123934 9.65090185243663 1.3618253072908824 0.9111184302088126 0.2292808036344144 0.07681918559674786 0.04781777026067214 0.00031301206519398567 0.005947128018707073 0.024793285540451772 8.646212018002823e-12 11.063174119123934 -0.4507068770820698 LTLLQVASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTLLQVASR 9 0 O95239-2;O95239 O95239-2 KIF4A Chromosome-associated kinesin KIF4A 0 12728500.0 3604800.0 2925900.0 6197800.0 False True 4937591.976057081 2796624.063342584 4734007.287697734 1.0 0.566394322759701 0.9587684261181258 22.235376191863917 -10.36420425532563 8.457921341449136 1.0000009954154767 0.7625813744389135 0.328032008376016 0.16018605691836804 3.006885500736623e-06 2.259831079216208e-07 0.15510013437627904 0.051699827561622745 4.323104610044329e-11 10.36420425532563 -0.23741962097656322 LTLLQVASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTLLQVASR 9 0 O95239-2;O95239 O95239-2 KIF4A Chromosome-associated kinesin KIF4A 0 6962000.0 3097900.0 1435700.0 2428400.0 False True 2576041.110239592 1427965.599135861 2936167.2123470185 1.0 0.5543256252626532 1.1397982744436606 21.29672418648227 -6.703215840870304 1.8190432650861064 0.7241196021285617 1.1381803195616969 0.43281713556846746 0.18801884341667052 0.3889765383149993 2.5043744673826116 0.08238330702140573 0.2110592672729705 1.980542467463161e-07 6.703215840870304 0.4140607174331351 LTLLTLHFPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTLLTLHFPR 10 0 Q92889 Q92889 ERCC4 DNA repair endonuclease XPF 0 7989150.0 2778800.0 4483500.0 726850.0 False True 3643033.7099374766 3814579.2765461216 651642.5344375257 1.0 1.047088657494632 0.17887359446056553 21.796708914098698 -6.8940807116888925 0.9979125925869483 1.0421897670261573 0.09793932049712786 0.9833848045533451 0.05138536774116352 0.11589527273339502 0.20299871543089162 0.039008763215358656 0.09879423713823546 1.2762016104040856e-07 6.8940807116888925 -0.9442504465290295 down LTLLTLHFPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTLLTLHFPR 10 0 Q92889 Q92889 ERCC4 DNA repair endonuclease XPF 0 12844600.0 3551300.0 4818000.0 4475300.0 False True 3438565.925383343 6741852.525538087 3303084.6738778395 1.0 1.9606582138705055 0.9605994898904259 21.71337557503408 -6.655360371025987 1.9901370118764519 1.6207284322384965 0.9648550081388451 0.21585182619138854 0.4094874662271623 0.49547438440293795 3.7675990986471035 0.1665547668510555 0.4535207596097923 2.2112590786122202e-07 6.655360371025987 -0.6558734240996514 LTLLTLHFPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTLLTLHFPR 10 0 Q92889 Q92889 ERCC4 DNA repair endonuclease XPF 0 25007500.0 7218200.0 6902300.0 10887000.0 False True 10950537.121105433 5670530.637083948 8735179.67805839 1.0 0.5178312784452276 0.7976941753133469 23.38449829960424 -10.226456966768371 5.668093578827926 1.0000141192948393 0.6577627268792788 0.6659871624212185 0.11425354921070764 2.0386339681361375e-05 2.782013539261192e-06 0.11063008419679933 0.036875174444841806 5.936671703782566e-11 10.226456966768371 -0.34225139241556046 LTLLTLHFPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTLLTLHFPR 10 0 Q92889 Q92889 ERCC4 DNA repair endonuclease XPF 0 28895800.0 2778800.0 11950000.0 14167000.0 False True 3806197.454246394 11422009.486634485 10821046.378523644 1.0 3.0008977789345876 2.8430070979242332 21.85991897562159 -10.537071572106385 5.93213531643302 0.9965518376972073 2.921952438429337 0.9949638772843232 0.06445860060265315 0.0029382761623944625 0.00022929510371962855 0.062384521454114196 0.020803923887825808 2.9035441084518135e-11 10.537071572106385 1.9254006007321296 LTLLTLHFPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTLLTLHFPR 10 0 Q92889 Q92889 ERCC4 DNA repair endonuclease XPF 0 8748600.0 3551300.0 2274800.0 2922500.0 False True 2953063.2992652664 2262545.2008875515 3533581.2378867413 1.0 0.7661688801084899 1.1965816102776767 21.493780850468355 -6.759184142056219 1.6156804017098774 0.8640392570204853 1.1980834040375112 0.6875764353216455 0.09833833001169028 0.284289367949394 1.4624762440156165 0.048028608489872913 0.11550707916512347 1.7410684990284264e-07 6.759184142056219 0.3340441470170259 LTLLTLHFPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTLLTLHFPR 10 0 Q92889 Q92889 ERCC4 DNA repair endonuclease XPF 0 21921200.0 7218200.0 8057500.0 6645500.0 False True 9344102.191993771 7609093.041888258 5436087.188588199 1.0 0.8143204007772832 0.5817666670261757 23.15562462169669 -6.968080946378201 0.30050900375754963 1.0400894030512506 0.3487054899643453 0.9999633056919551 0.00103643707244042 0.07693043611180987 0.011247064939926976 0.003848430070978506 0.02084548277867788 1.0762645943634621e-07 6.968080946378201 -0.6913839130869053 LTLMFEIQGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTLMFEIQGLK 11 0 Q8IWJ2;B8ZZW2 Q8IWJ2 GCC2 GRIP and coiled-coil domain-containing protein 2 0 7715200.0 1760100.0 3045200.0 2909900.0 False True 2670200.3805460734 2501760.267743806 2334756.9895455246 1.0 0.9369185496229236 0.8743751991631622 21.348516579841043 -6.971231172971614 0.2268676394634261 1.0264540120311885 0.7830593766680789 0.9999904441307113 0.00015843386686496586 0.075905223088226 0.0075852736127156855 0.0016447852595409406 0.006250205836267345 1.0684859776124088e-07 6.971231172971614 -0.24339463536310957 LTLNCQNSYVEPHK(ub)IR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTLNCQNSYVEPHKIR 16 1 Q9NZD8;Q9NZD8-2;H3BRR0 Q9NZD8 SPG21 Maspardin 1 35291200.0 5034300.0 5706900.0 24550000.0 True False 7637401.156629226 4688459.1067867875 19697681.739352774 1.0 0.6138814775648165 2.5791079105822905 22.86465037299353 -6.855694966885176 1.2072450874014005 0.7924539337799482 2.66676009256501 0.948191514137979 0.19350653794052539 0.15130726122542845 0.4215005465414284 0.12521338354240963 0.29102045709615343 1.3941356508233837e-07 6.855694966885176 1.8743061587850618 up LTLNCQNSYVEPHK(ub)IR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTLNCQNSYVEPHKIR 16 1 Q9NZD8;Q9NZD8-2;H3BRR0 Q9NZD8 SPG21 Maspardin 1 33371400.0 5034300.0 3637100.0 24700000.0 True False 6517000.590888898 3434692.187732146 20204853.44340207 1.0 0.5270357336677278 3.1003301536675467 22.63577669508598 -6.859264982991437 1.1894077329366095 0.7438637802783007 3.2232237462567888 0.9527422038915907 0.24312263007067167 0.14756420577652277 0.39709220910643894 0.15947087710958044 0.3719589972701952 1.3827224591209643e-07 6.859264982991437 2.479359965978488 up LTLSALLDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTLSALLDGK 10 0 P21796 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 0 24507700.0 5182000.0 9203700.0 10122000.0 False True 6793652.182559381 7830543.8357416075 9074672.537080035 1.0 1.1526265439146455 1.3357576003635385 22.695755927173053 -6.968701777926326 0.2875132005726398 0.9631362576915963 1.5308862905082898 0.9999704069307823 0.0007466703232259109 0.07672627162134446 0.01053077191748272 0.003242835888158095 0.016655509736955124 1.0747271544860545e-07 6.968701777926326 0.5677500328166936 LTLSALLDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTLSALLDGK 10 0 P21796 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 0 19097700.0 8133200.0 4694900.0 6269600.0 False True 7875016.017888589 6569598.053580063 4627403.676031668 1.0 0.8342329766259284 0.5876056208038476 22.90885142728821 -6.965392959480317 0.3512484263017816 1.0234938210471813 0.39000678612856543 0.9999210109013643 0.0015058530671183132 0.07782792596282187 0.01439155417758369 0.003374748782023653 0.02118085389226357 1.0829465959814965e-07 6.965392959480317 -0.6334870349186159 LTLSALLDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTLSALLDGK 10 0 P21796 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 0 32545300.0 5182000.0 9507800.0 17855500.0 False True 7097925.438284446 9087713.9579099 13638398.645565676 1.0 1.2803338154121808 1.9214626532991659 22.758965988695945 -6.957340537175588 0.47142603130407157 0.9832985669142573 2.24484405893669 0.9996584770377557 0.0071274554707165694 0.08066524003440592 0.024748381991975058 0.008888572836397884 0.052910646050252766 1.1032132337109791e-07 6.957340537175588 1.2615454920224325 LTLSALLDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTLSALLDGK 10 0 P21796 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 0 14313300.0 8133200.0 2419100.0 3761000.0 False True 6763116.161851777 2406067.8281462463 4547407.711100778 1.0 0.3557631971069756 0.6723834993033261 22.689256702722485 -10.552946676518758 6.460955635521873 1.0006283173176684 0.5140733482052748 0.7584849027426775 0.12925969709781177 0.0011712883935250103 8.104497965694005e-05 0.12530600327527677 0.04171838784963668 2.799325004846063e-11 10.552946676518758 -0.4865549691123936 LTLSALVDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTLSALVDGK 10 0 A0A0A0MR02;P45880-2;P45880;P45880-1 A0A0A0MR02 VDAC2 Voltage-dependent anion-selective channel protein 2 0 6430100.0 2162400.0 2215100.0 2052600.0 False True 2834927.340711391 1884615.7143921708 1840216.6419295073 1.0 0.6647844857707179 0.6491230358897759 21.434880328640293 LTLTFNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTLTFNR 7 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 189577000.0 49334000.0 64760000.0 75483000.0 False True 64677351.751135655 55098060.43250281 67672743.24406368 1.0 0.8518911016101608 1.0463128345831727 25.946757272310045 -6.70308495330971 1.8199588993985716 0.90830820468249 1.0457670547244693 0.43215912667856704 0.0624842414461472 0.3891555340845785 2.5080661793918813 0.02736856986154053 0.0701155854537636 1.9811394528038417e-07 6.70308495330971 0.13745885004197933 LTLTFNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTLTFNR 7 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 188857000.0 64678000.0 43062000.0 81117000.0 False True 62624832.29294726 60256881.16536335 59870024.24216227 1.0 0.962188303890267 0.9560109312884303 25.900231499039027 -13.999999998239664 0.25495586758737615 1.269672832043826 0.9536416304645684 0.9995521344983481 0.0004114677939966455 14.20008894611204 0.1597766570482224 1.966992825566893 0.00277439053772932 1.0000000040533232e-14 13.999999998239664 -0.31603120157925757 LTLTFNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTLTFNR 7 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 86744000.0 26127000.0 26622000.0 33995000.0 False True 39636569.13955298 21871096.10136462 27275873.349462163 1.0 0.5517908481019274 0.688149200134575 25.240328755404857 -10.73703410277498 10.28726956828018 1.000749232800649 0.6199700241182537 0.9119443209022797 0.05566806410779804 0.0009581726494036362 2.449304297234875e-05 0.05398963158355538 0.017966790433759046 1.832170546370656e-11 10.73703410277498 -0.38077920868239534 LTLTFNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTLTFNR 7 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 233177000.0 49334000.0 68723000.0 115120000.0 False True 67574113.00122063 65686590.62342944 87931026.97082244 1.0 0.9720673747096452 1.3012531436296335 26.009967333832936 -6.886271739301255 1.0441442061763604 0.980699637808447 1.327585638354398 0.9784043048324347 0.021901074272237597 0.12222199984976849 0.23991441458787618 0.01605449750294665 0.039524411298977484 1.2993563126620739e-07 6.886271739301255 0.346886000545951 LTLTFNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTLTFNR 7 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 128605000.0 64678000.0 30087000.0 33840000.0 False True 53782622.72122285 29924915.35919807 40915787.5415183 1.0 0.556404910082408 0.7607622215376411 25.680636774473303 -10.059337648119222 4.822609753336553 1.000008999038602 0.6585835658059312 0.7882064358786122 0.08342852306343633 115679318.66293482 9.123481609133108 12752.294190761873 0.028559802510501296 8.722929287551582e-11 10.059337648119222 -0.3414254332326708 LTLTFNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTLTFNR 7 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 115952000.0 26127000.0 52481000.0 37344000.0 False True 33821916.540165275 49560386.21549333 30547775.181797884 1.0 1.4653334667371025 0.9031946828181904 25.011455077497306 -6.6869023914653765 1.8775599178725828 1.2925785860223145 0.9052135397745622 0.35592410051633316 0.19692890068400523 0.4233502212681914 2.891065528457866 0.08398638702462985 0.2195530824718384 2.0563527133474462e-07 6.6869023914653765 -0.38736504624775225 LTLTFSAQTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTLTFSAQTK 10 0 H9KV28;A0A140T8Z0;A0A0G2JH68;O60610-2;O60610-3;O60610;A0A2R8Y5N1 H9KV28 DIAPH1 Protein diaphanous homolog 1 0 44436000.0 13169000.0 15275000.0 15992000.0 False True 19978335.782859623 12549056.905880282 12831174.1904574 1.0 0.6281332460457854 0.6422544064689253 24.251933074278114 -10.245655355680682 6.804502473637392 1.0000026861000268 0.6351938262573572 0.9988774896864882 0.005764939602112929 2.3492036634645455e-07 2.6036951369134223e-08 0.005581919847098261 0.0018606262559062363 5.679951721662075e-11 10.245655355680682 -0.36480885984266964 LTLTFSAQTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTLTFSAQTK 10 0 H9KV28;A0A140T8Z0;A0A0G2JH68;O60610-2;O60610-3;O60610;A0A2R8Y5N1 H9KV28 DIAPH1 Protein diaphanous homolog 1 0 40659000.0 13169000.0 16665000.0 10825000.0 False True 17047530.09979855 15737578.100287642 8854961.073879648 1.0 0.9231588393249772 0.5194278010973735 24.023059396370563 -6.938705562360039 0.67149660076373 1.0046491238459228 0.4145782925712954 0.9979894107403267 0.009451277129927648 0.08836213039742945 0.057336001760925494 0.009112276717187534 0.03495114819908212 1.1515808589978398e-07 6.938705562360039 -0.5900708312746273 LTLTILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTLTILR 7 0 H0YDF9 H0YDF9 SCRIB 0 7074600.0 3561000.0 1480600.0 2033000.0 False True 4668505.484773051 1259700.2513335967 1822644.6619130345 1.0 0.26982944658462454 0.39041287792374485 22.15452934735602 -9.99389453089903 5.919029133657511 1.0000007427260638 0.33012116228041016 0.9762744679285128 0.049227979702893984 4.824916105480386e-07 8.195754652502593e-08 0.047664838943283334 0.015888262129665667 1.014157645619435e-10 9.99389453089903 -0.6698795804456537 LTLTILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTLTILR 7 0 H0YDF9 H0YDF9 SCRIB 0 4838900.0 2342000.0 1044300.0 1452600.0 False True 2267654.4919459843 1461294.435952556 1072120.4829340938 1.0 0.6444078853911067 0.4727882870789788 21.112769412105205 -13.9999999996606 0.09615870267211632 2.777732276041498 0.08447185849422077 0.9998127923991756 0.0030040703443249845 12.110817684458157 0.0915487376931162 4.316879271430247 0.3471750258484555 1.0000000007814966e-14 13.9999999996606 -2.693260417547277 LTLTILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTLTILR 7 0 H0YDF9 H0YDF9 SCRIB 0 11105000.0 3561000.0 2203900.0 5340100.0 False True 4877597.932406582 2106524.4106773 4078878.3628117484 1.0 0.43187741996560003 0.8362473535819404 22.217739408878913 -9.849469339164806 5.754042358423127 1.0000000877414685 0.6340623867728242 0.5219727202666278 0.165083334117264 1.8571953112146253e-07 3.725449171367045e-08 0.15984128905055492 0.053280416980549736 1.4142645674673926e-10 9.849469339164806 -0.3659377009686443 LTLVCESAPGPITMDLTGDLEALKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTLVCESAPGPITMDLTGDLEALKK 25 1 P52566;F5H3P3;F5H6Q0 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 149510000.0 14546000.0 113700000.0 21264000.0 False True 22067345.455044128 93409346.65784524 17061161.079657707 1.0 4.232921755275909 0.7731406169543554 24.3954097582977 -6.66140005425845 1.9675412906725787 3.078549920934705 0.7874171997236317 0.24170908123659163 1.3760379888174046 0.48114821582209205 3.581973429275558 0.5646930780705571 1.5260182116871106 2.1807201963773088e-07 6.66140005425845 -2.2911327212110733 LTLVCESAPGPITMDLTGDLEALKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTLVCESAPGPITMDLTGDLEALKK 25 1 P52566;F5H3P3;F5H6Q0 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 41620000.0 14546000.0 14245000.0 12829000.0 False True 18830083.744526517 13452253.22763863 10494253.636656098 1.0 0.714402198638596 0.5573131685995046 24.16653608039015 -13.999999999999764 0.0719203979129153 2.6278887869732426 0.009070369511249723 0.999917753104801 0.0016618570815288354 12.340456344134312 0.07302251014530642 3.3321825469409214 0.5034787256288483 1.000000000000544e-14 13.999999999999764 -2.618818417461993 LTLYDIAHTPGVAADLSHIETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTLYDIAHTPGVAADLSHIETK 22 0 P40926;P40926-2 P40926 MDH2 Malate dehydrogenase, mitochondrial 0 45587500.0 18571600.0 18706600.0 8309300.0 False True 24347547.44763022 15915648.197755683 7449533.344433823 1.0 0.6536858889787183 0.3059664781620087 24.537273119749425 -7.375285631875211 0.28875706500281645 1.0892504866648078 3.058058501338392e-12 0.9998406736340295 0.003576418876497784 0.11406263443373939 0.023403011390456047 0.017167040151224597 0.05503338154596759 4.214192483234097e-08 7.375285631875211 -1.0892504866617498 down LTLYDIAHTPGVAADLSHIETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTLYDIAHTPGVAADLSHIETK 22 0 P40926;P40926-2 P40926 MDH2 Malate dehydrogenase, mitochondrial 0 304307500.0 109763000.0 41411500.0 153133000.0 False True 106278633.64622867 57947327.90811961 113022873.40847214 1.0 0.5452396772526242 1.0634580962406153 26.663276344387704 -6.674856688543684 1.9197044103079726 0.7109641076339877 1.0614384105919827 0.30100281973670273 0.19295601444459315 0.4500172603440502 3.2016218578568907 0.08077906556300413 0.21449933761897105 2.1141865784532254e-07 6.674856688543684 0.3504743029579951 LTLYDIAHTPGVAADLSHIETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTLYDIAHTPGVAADLSHIETK 22 0 P40926;P40926-2 P40926 MDH2 Malate dehydrogenase, mitochondrial 0 252781000.0 16575000.0 225323000.0 10883000.0 False True 25145486.79481346 185112350.19336557 8731970.27981164 1.0 7.361653075316365 0.3472579533283367 24.583796147223197 -6.667900216056343 1.9446901055796606 5.0678760901766875 0.37575406925229315 0.2698552537180984 2.7035964383526956 0.46593841124158547 3.395069458213029 1.1199992257164915 3.0007126276452856 2.1483240185500657e-07 6.667900216056343 -4.692122020924394 LTLYDIAHTPGVAADLSHIETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTLYDIAHTPGVAADLSHIETK 22 0 P40926;P40926-2 P40926 MDH2 Malate dehydrogenase, mitochondrial 0 134250900.0 18571600.0 42513300.0 73166000.0 False True 25438022.398618948 40634921.833317004 55885697.701070115 1.0 1.597408839278446 2.1969356275157694 24.600483181272317 -6.971081370713256 0.23090253892668486 0.7589113426014293 3.052582001419071 0.9999896320867093 0.001573396392420742 0.07595334963695552 0.007763113039964144 0.015302661743587907 0.059441066204219184 1.0688545966659243e-07 6.971081370713256 2.293670658817642 LTLYDIAHTPGVAADLSHIETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTLYDIAHTPGVAADLSHIETK 22 0 P40926;P40926-2 P40926 MDH2 Malate dehydrogenase, mitochondrial 0 182800800.0 109763000.0 26440800.0 46597000.0 False True 91272797.82537478 26298358.16231211 56340217.25981465 1.0 0.2881291993768695 0.6172728195273037 26.44368161982198 -10.564225719971649 6.448446142358459 1.0008475350588526 0.4527010094531655 0.7866222700507797 0.13437232024350187 0.0016395602937548895 0.0001107984682310324 0.13028620925251735 0.04336847987452769 2.7275597939425105e-11 10.564225719971649 -0.5481465256056871 LTLYDIAHTPGVAADLSHIETK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTLYDIAHTPGVAADLSHIETK 22 0 P40926;P40926-2 P40926 MDH2 Malate dehydrogenase, mitochondrial 0 61443300.0 16575000.0 37054900.0 7813400.0 False True 21456664.24209592 34992762.24112506 6391441.372254161 1.0 1.630857520362956 0.29787674822793586 24.354922469315646 -6.778012222673962 1.5436660996984457 1.3581271937434072 0.28797702955251003 0.7602839265394529 0.2665653107832772 0.25367120100382773 1.1938209812818867 0.13603009430329327 0.32150460166323785 1.6672002906278385e-07 6.778012222673962 -1.0701501641908973 LTMAQLK(ub)ISQGNISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTMAQLKISQGNISK 15 1 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 1 25686100.0 8253200.0 9737000.0 7695900.0 True False 10820025.124102497 8284277.5545287365 6899602.092285551 1.0 0.7656430978219104 0.6376696923666211 23.367200513318593 -13.999999999995868 0.07339082716234671 2.321035411645298 0.20397240925948723 0.9999124563067483 0.0014037496109277536 12.325278108178946 0.07424537695537296 2.733061682666665 0.39741054336299525 1.0000000000095138e-14 13.999999999995868 -2.1170630023858106 LTMAQLK(ub)ISQGNISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTMAQLKISQGNISK 15 1 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 1 47243000.0 16336000.0 18511000.0 12396000.0 True False 15817422.621874308 25902538.833589725 9149115.727971235 1.0 1.637595419481835 0.5784201349794306 23.915011202481793 -6.743747117891333 1.6734259412141075 1.3777202570060756 0.5773321423705925 0.6214633238666905 0.26787748586160165 0.31107379593042794 1.7118863621900353 0.12657790021880816 0.309288514085192 1.8040679123887644e-07 6.743747117891333 -0.8003881146354831 LTMAQLK(ub)ISQGNISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTMAQLKISQGNISK 15 1 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 1 69359000.0 25118000.0 24002000.0 20239000.0 True False 38105842.37177217 19718655.571518056 16238752.778931156 1.0 0.5174706644492166 0.42614863674973913 25.18350887228716 -13.999999999999998 0.2340771675749095 4.1046702744742785 0.3834351875413803 0.9995156247836495 0.005541017843181708 13.421737327363171 0.15316295390365717 19.411652529312825 0.046230999519850775 1.0000000000000041e-14 13.999999999999998 -3.7212350869328983 LTMAQLK(ub)ISQGNISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTMAQLKISQGNISK 15 1 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 1 27561800.0 8253200.0 10658000.0 8650600.0 True False 11304631.074343735 10187094.318707136 6607506.444699421 1.0 0.9011434563156255 0.5844955400353925 23.430410574841485 -6.949969234338222 0.5591801173077136 1.004159230873098 0.46636790642913617 0.9991988741391211 0.005016239645967164 0.08349807735534444 0.03601333926037403 0.005382462347702305 0.026317363186857897 1.1220979415264995e-07 6.949969234338222 -0.5377913244439618 LTMAQLK(ub)ISQGNISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTMAQLKISQGNISK 15 1 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 1 38091100.0 16336000.0 13437000.0 8318100.0 True False 13584107.807506362 13364612.213964341 10057376.251451058 1.0 0.9838417364870492 0.7403781237582281 23.69541647791607 -6.920371261316887 0.8219776455264498 1.005300334096975 0.700781377011676 0.9942832291526331 0.00897949311824504 0.09795380991689193 0.10448893457196502 0.00775198987180813 0.023303626605503523 1.2012371050868633e-07 6.920371261316887 -0.3045189570852991 LTMAQLK(ub)ISQGNISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTMAQLKISQGNISK 15 1 O76094;O76094-2;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 1 57932000.0 25118000.0 22843000.0 9971000.0 True False 32515746.149801787 21571766.969389193 8156380.311099686 1.0 0.6634252484936654 0.25084401488198377 24.95463519437961 -7.322798872747075 0.36234887857338005 1.0455176166734463 1.0220741050049519e-13 0.9996365443946045 0.005840713236631136 0.10565316184436178 0.029114546192620695 0.012757299093263676 0.052683562604008624 4.755554106632238e-08 7.322798872747075 -1.0455176166733442 down LTMQITALNENLGTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTMQITALNENLGTVK 16 0 Q15075 Q15075 EEA1 Early endosome antigen 1 0 3685260.0 315050.0 573210.0 2797000.0 False True 431532.49890612037 547883.6868480127 2136406.2060231944 1.0 1.2696232340248481 4.9507423228579786 18.71910968794335 -6.921617022053382 0.8126478488242445 0.9234151598459011 5.5670026965959565 0.9946183558805861 0.13220968300994582 0.0972296297687271 0.10075369949100328 0.11489853005740984 0.3496787067662735 1.1977963296064153e-07 6.921617022053382 4.643587536750055 up LTMQVSSLQR ddPTM_RPMI8226_Bortezomib_1h_R1 2 LTMQVSSLQR 10 0 H0Y993;P35659;A0A494C028;H0Y8X0;A0A494C198;D6R9L5 H0Y993 DEK Protein DEK 0 114497800.0 33234300.0 31658400.0 49605100.0 False True 43570489.14141903 26935090.123476636 44472440.09771873 1.0 0.6181957250021223 1.0207009600780976 25.376847973882757 -11.01560975894132 12.646132293837985 1.2844490949218936 0.8194483425401706 0.21153454437957653 0.16432207412252225 0.04976413690267884 6.14264132724579e-05 0.006008121923132969 0.05303472137423244 9.646954741804889e-12 11.01560975894132 -0.465000752381723 LTMQVSSLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTMQVSSLQR 10 0 H0Y993;P35659;A0A494C028;H0Y8X0;A0A494C198;D6R9L5 H0Y993 DEK Protein DEK 0 94134000.0 22579000.0 11135000.0 60420000.0 False True 21862242.00411976 15581263.568257902 44594189.43885308 1.0 0.7127019985105708 2.0397811638188648 24.381938023243624 -6.850033682703388 1.2349823890346667 0.8466882549188001 2.092850725904891 0.9403473847555617 0.13923338028996204 0.15742017361402424 0.46201406435505743 0.08822082353208763 0.20414593010659687 1.4124279962859546e-07 6.850033682703388 1.246162470986091 up LTMQVSSLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTMQVSSLQR 10 0 H0Y993;P35659;A0A494C028;H0Y8X0;A0A494C198;D6R9L5 H0Y993 DEK Protein DEK 0 86478000.0 23535000.0 62943000.0 0.0 False True 35704315.638970405 51710329.87409639 0.0 1.0 1.4482935451549674 0.0 25.0895951299125 -6.847527093595957 1.4118757111136262 1.2390116329671248 5.7493774571267154e-21 0.8916027617921136 0.19931844937232168 0.17694963623493967 0.7086672784406155 0.11344287927652176 0.2403891150387079 1.4206035853003893e-07 6.847527093595957 -1.2390116329671248 down LTMQVSSLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTMQVSSLQR 10 0 H0Y993;P35659;A0A494C028;H0Y8X0;A0A494C198;D6R9L5 H0Y993 DEK Protein DEK 0 106313000.0 31841000.0 26002000.0 48470000.0 False True 43613478.170670636 24853145.662884545 37022384.27098476 1.0 0.5698501175629208 0.8488748392436566 25.378270714009236 -10.121505098364963 5.155396539241734 1.00000859730048 0.7093624784028955 0.5912741190458656 0.1139113656246867 1.1256478676734594e-05 1.918299590380765e-06 0.11029746676390641 0.036764735167149225 7.559531858355146e-11 10.121505098364963 -0.2906461188975845 LTMQVSSLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTMQVSSLQR 10 0 H0Y993;P35659;A0A494C028;H0Y8X0;A0A494C198;D6R9L5 H0Y993 DEK Protein DEK 0 59758000.0 22579000.0 15668000.0 21511000.0 False True 18775438.9193001 15583593.374145484 26008850.644373555 1.0 0.8299988853057608 1.385259261110424 24.1623432986779 -6.82451672398495 1.3520984837264107 0.9087637120908478 1.3986090711994277 0.8944849210925936 0.07545584010421212 0.18767410191526307 0.6728848196902542 0.04383834801192351 0.10094563266963189 1.4979015701437564e-07 6.82451672398495 0.48984535910857985 LTMQVSSLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTMQVSSLQR 10 0 H0Y993;P35659;A0A494C028;H0Y8X0;A0A494C198;D6R9L5 H0Y993 DEK Protein DEK 0 125860000.0 23535000.0 61614000.0 40711000.0 False True 30466521.444206767 58185126.736941054 33302015.73013533 1.0 1.909805385675397 1.0930691838620694 24.86072145200495 -10.222942151639618 4.582743778882368 0.9998622285066175 1.5014372847726332 0.3344796551353203 0.33343115816354674 0.0004694740119809181 7.960419320784716e-05 0.32293133543438446 0.10761444355429688 5.984913092557953e-11 10.222942151639618 0.5015750562660156 LTNGIWILAELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTNGIWILAELR 12 0 P63010;P63010-2;A0A087X253;P63010-3 P63010 AP2B1 AP-2 complex subunit beta 0 55711000.0 12269000.0 20731000.0 22711000.0 False True 18612969.984046236 17031391.07795772 18222160.89541507 1.0 0.9150281278353676 0.9790033998353761 24.14980494203663 -10.285434528897833 5.246746177579973 1.0000094406662166 0.947015763835419 0.47768424346264104 0.026117795425986193 2.8847424340503045e-06 3.9289379969331985e-07 0.025292952308591007 0.008429482227038225 5.182812184547004e-11 10.285434528897833 -0.05299367683079759 LTNGIWILAELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTNGIWILAELR 12 0 P63010;P63010-2;A0A087X253;P63010-3 P63010 AP2B1 AP-2 complex subunit beta 0 34231400.0 12269000.0 8897400.0 13065000.0 False True 15882462.358146295 8402251.86855682 10687304.05822057 1.0 0.5290270286236322 0.6728996938399121 23.92093126412908 -10.801427363822917 10.623000405602673 1.0031015270908517 0.6009633612317764 0.9111640269748627 0.058735769619025976 0.00432313016234293 8.081088076989146e-05 0.056984796323528805 0.018956888130096924 1.5796927908105944e-11 10.801427363822917 -0.40213816585907525 LTNSMMMHGR ddPTM_RPMI8226_Bortezomib_1h_R1 3 LTNSMMMHGR 10 0 M0R0F0;P46782;M0R0R2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 0 19018940.0 4978280.0 7003790.0 7036870.0 False True 6526573.289732099 5958851.832559587 6308762.194823402 1.0 0.9130138539828127 0.9666270360816499 22.63789428766527 -10.541249884801427 5.963020361433782 1.0001106401342412 0.9398204450322313 0.6268571613697227 0.02188748993817809 3.225325019834878e-05 2.4813005985413075e-06 0.021231388094455815 0.007064157001737179 2.8757432905136928e-11 10.541249884801427 -0.06029019510200995 LTNSMMMHGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTNSMMMHGR 10 0 M0R0F0;P46782;M0R0R2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 0 8434950.0 2411400.0 891750.0 5131800.0 False True 2334851.4269336234 1247830.425414815 3787627.6293000025 1.0 0.5344367573116202 1.6222135531228727 21.15489931949653 -6.790380366623055 1.4946301316935726 0.7399311196685324 1.633937912290333 0.8026322658716674 0.19796946063360746 0.23477051413694613 1.0360489168319909 0.10425093117611885 0.2440287275721864 1.620390294912625e-07 6.790380366623055 0.8940067926218006 LTNSMMMHGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LTNSMMMHGR 10 0 M0R0F0;P46782;M0R0R2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 0 14102750.0 4554980.0 5052500.0 4495270.0 False True 6239079.199706072 4829263.843616803 3433579.808991742 1.0 0.7740347075325336 0.5503343841433365 22.572901692635742 -6.971249486015226 0.22636291117918336 1.0952198391733894 0.22278516654262936 0.9999905550566549 0.0005641477083623101 0.0758993128292069 0.007563193311222027 0.005905155493922139 0.022377844299979386 1.0684409233495107e-07 6.971249486015226 -0.87243467263076 LTNSMMMHGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTNSMMMHGR 10 0 M0R0F0;P46782;M0R0R2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 0 5387400.0 2411400.0 1935900.0 1040100.0 False True 2005185.9431330077 1925470.9224539376 1257580.1011209579 1.0 0.9602455717625273 0.6271638325750721 20.935304594930805 -6.929246198055788 0.7529557185271208 1.0052094444265283 0.5600786681500598 0.9963879545765669 0.01004733185534296 0.09303126801552124 0.0796121541508824 0.009112870610384507 0.0302640817117474 1.1769385873326578e-07 6.929246198055788 -0.44513077627646847 LTPADK(ub)AEHMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTPADKAEHMK 11 1 Q9Y679;Q9Y679-3 Q9Y679 AUP1 Ancient ubiquitous protein 1 1 3004300.0 299350.0 842250.0 1862700.0 True False 392450.7489095237 716589.5830647852 1669965.672280084 1.0 1.8259350633319573 4.2552235584218 18.5821520870084 -6.9518943465621375 0.5376444146977597 0.9636698812564873 5.229221659888547 0.9993416844826147 0.03544937028190257 0.08273386779398098 0.03288234425287764 0.039117649944621725 0.20110564673827458 1.117134986891168e-07 6.9518943465621375 4.26555177863206 LTPADK(ub)AEHMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LTPADKAEHMK 11 1 Q9Y679;Q9Y679-3 Q9Y679 AUP1 Ancient ubiquitous protein 1 1 29782040.0 2051980.0 5135560.0 22594500.0 True False 1986841.0180970656 7186215.889591601 16676322.629529389 1.0 3.6169053407576284 8.393385518838064 20.922045005787346 -6.961792973955581 0.40938326483475657 0.7631187338248113 11.42425371318384 0.999831021885925 0.03978986060339962 0.07906676965574568 0.01880995374391855 0.06149588514447782 0.39888019514923306 1.0919607447195152e-07 6.961792973955581 10.661134979359028 LTPADK(ub)AEHMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTPADKAEHMK 11 1 Q9Y679;Q9Y679-3 Q9Y679 AUP1 Ancient ubiquitous protein 1 1 7262940.0 573640.0 1412800.0 5276500.0 True False 870253.8187014658 1160674.801743216 4233597.462227897 1.0 1.3337198605748113 4.864784699876394 19.731076713991435 -6.925290821255683 0.7844801946678508 0.9359122250169228 5.509802835537171 0.9955289928026737 0.11691677592315407 0.09515797739595423 0.09020634296477412 0.10367027648209604 0.3281615786084116 1.1877066244014862e-07 6.925290821255683 4.573890610520248 up LTPADK(ub)AEHMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTPADKAEHMK 11 1 Q9Y679;Q9Y679-3 Q9Y679 AUP1 Ancient ubiquitous protein 1 1 3725920.0 299350.0 768370.0 2658200.0 True False 410027.7846295735 734420.8727401952 2030387.907347466 1.0 1.7911490398234458 4.951830055082133 18.64536214853129 -6.944903046285201 0.6122516232189039 0.9651452340703932 5.9430696632342235 0.9987381360294665 0.06064670206151319 0.08559929346996278 0.044946523076974824 0.06151527776807564 0.2667295495096842 1.1352642285147618e-07 6.944903046285201 4.9779244291638305 LTPADK(ub)AEHMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LTPADKAEHMK 11 1 Q9Y679;Q9Y679-3 Q9Y679 AUP1 Ancient ubiquitous protein 1 1 20024580.0 2051980.0 8805000.0 9167600.0 True False 1706312.28812726 8757565.717344346 11084502.773806844 1.0 5.132451883679566 6.496174733625396 20.702450281221623 -9.155752187386755 0.400840932928635 2.6499723539871305e-19 6.714544016554719 0.9977837869163579 0.11000779096276696 0.569671436289558 0.1531007657019952 1.2798556478464231 0.34153338791599186 6.986309359025329e-10 9.155752187386755 6.714544016554719 LTPEEEEILNK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTPEEEEILNKK 12 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 56340200.0 12991000.0 16045000.0 27304200.0 True False 17031326.805022966 13651148.542920131 24479023.304380644 1.0 0.8015317126610514 1.4372939692027498 24.021687495027415 -6.822819007327484 1.3595822939578524 0.8933206912964051 1.4520366653364114 0.8907566504368972 0.08778046894727151 0.18984198092683605 0.6887402164868617 0.050725442244825815 0.11683835267088187 1.5037685326041903e-07 6.822819007327484 0.5587159740400063 LTPEEEEILNK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTPEEEEILNKK 12 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 30824310.0 768360.0 849950.0 29206000.0 True False 743968.8323789996 1189339.4674306947 21556072.438780922 1.0 1.5986415232309226 28.97442943926934 19.504882657175866 -6.9116191656939625 0.8846435501530738 0.19517528477273985 32.6375206785071 0.991518184743797 1.2017210590893923 0.1033569519943117 0.13303430313922443 0.9918092804751539 2.769526226269006 1.2256905403467875e-07 6.9116191656939625 32.442345393734364 up LTPEEEEILNK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTPEEEEILNKK 12 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 31870200.0 2457200.0 24524000.0 4889000.0 True False 3727752.0453825393 20147500.59311345 3922687.00707518 1.0 5.404731953153801 1.052292899130483 21.82987447041244 -6.643378943253391 2.0317548754654142 3.872993855789874 1.0703267062404203 0.1677998417285933 1.8830623620262965 0.5249600742812035 4.145576577949599 0.7535776613954343 2.0859018018913917 2.2731131623991652e-07 6.643378943253391 -2.802667149549454 LTPEEEEILNK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTPEEEEILNKK 12 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 29296030.0 12991000.0 13265830.0 3039200.0 True False 17794123.76857455 12679701.76636656 2321403.5542887724 1.0 0.7125780359446328 0.13045899783997822 24.084897556550306 -7.286968464919962 0.5619578058564202 1.0043707605565477 2.230670185553165e-28 0.9976820310387703 0.017415137708132147 0.09805831720910961 0.05830999536616676 0.017388297698519985 0.05771292837300024 5.1645386876489015e-08 7.286968464919962 -1.0043707605565477 down LTPEEEEILNK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTPEEEEILNKK 12 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 3517470.0 768360.0 971510.0 1777600.0 True False 638925.3841194651 966276.2828003634 2149287.9413062325 1.0 1.5123460529464434 3.3639107080841266 19.285287932610142 -6.947208788825592 0.5886900998582385 0.9785138286342545 3.990701721382643 0.9989636427439017 0.03268743849871969 0.08462629364108674 0.04075289404430376 0.033934175676971004 0.15505452740044356 1.1292528912661958e-07 6.947208788825592 3.0121878927483885 LTPEEEEILNK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTPEEEEILNKK 12 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 13291800.0 2457200.0 2704700.0 8129900.0 True False 3180893.8386532757 2554181.067377618 6650341.619818406 1.0 0.8029758919772705 2.090714735275171 21.60100079250489 -6.8678803595462306 1.145332280667668 0.8898908137392183 2.1631279803639805 0.962517129475579 0.10964772811522631 0.13889900666468186 0.34187877783996845 0.07439261539289148 0.17549755887749036 1.3555627945093967e-07 6.8678803595462306 1.2732371666247622 up LTPEEEEILNKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTPEEEEILNKK 12 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 23739600.0 9900600.0 13839000.0 0.0 True False 8232787.570947451 13764446.560173582 0.0 1.0 1.671905954278076 0.0 22.972949570306216 -6.811057570347725 1.4993228015816373 1.3710033871605343 3.0309004332672134e-20 0.8246320032053929 0.2876610717319679 0.21613734027102458 0.9715212894859699 0.15289168848744328 0.3397110419566686 1.5450496132211941e-07 6.811057570347725 -1.3710033871605343 LTPEEEEILNKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTPEEEEILNKK 12 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 104576000.0 22559000.0 23016000.0 59001000.0 True False 29203070.204370555 21735139.367309965 48263423.40138324 1.0 0.744275831794462 1.652683196103131 24.799616716048867 -6.831527183171954 1.3209855369793715 0.8634924793827299 1.6779137242359399 0.9089063673543929 0.11543797903990337 0.17893739086159843 0.6101176921517644 0.06860050179578209 0.15787282309529005 1.473916283357469e-07 6.831527183171954 0.81442124485321 LTPEEEEILNKK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTPEEEEILNKKR 13 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 2883560.0 1452500.0 930630.0 500430.0 True False 1904241.5660300106 791783.6315673268 448650.30406352103 1.0 0.41579999391466305 0.2356057719078538 20.860785075284852 -13.999999999999883 0.16472402649024928 3.90768171105765 0.06738518386150327 0.9995247475757126 0.00711273626138603 12.04453239441295 0.1284023223076189 11.187545716996999 0.15427901871066574 1.00000000000027e-14 13.999999999999883 -3.8402965271961467 LTPEEEEILNKK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTPEEEEILNKKR 13 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 4515910.0 1444900.0 861810.0 2209200.0 True False 1399032.4403982738 1205935.2272797774 1630544.2454206275 1.0 0.8619780302853265 1.1654799405197833 20.415997985049927 -6.783102073127316 1.5241442943800863 0.9221619948983812 1.168106339429522 0.7780858871693315 0.0584480330211163 0.2457909985797586 1.1280080287895855 0.030200106168016407 0.07106628800274767 1.6477750660399193e-07 6.783102073127316 0.24594434453114067 LTPEEEEILNKK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTPEEEEILNKKR 13 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 66828700.0 15488200.0 13163500.0 38177000.0 True False 23496731.739090804 10814370.578105075 30631299.21642645 1.0 0.46024999128340616 1.303640844886784 24.48595676433318 -6.733857920851729 1.7092235817602457 0.6765813952368136 1.3034968281383792 0.5770161435319914 0.2268376656827842 0.3290600749124491 1.8850264753772554 0.10509843132798571 0.2596573735805115 1.8456191134792567e-07 6.733857920851729 0.6269154329015656 LTPEEEEILNKK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTPEEEEILNKKR 13 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 5747500.0 1452500.0 1484300.0 2810700.0 True False 1989528.5023365826 1418718.7180762829 2146870.5481835534 1.0 0.7130929345370435 1.079085092604696 20.923995136807743 -6.697614412946665 1.8392740948058424 0.8214254145538035 1.077951572972281 0.4062556828965348 0.12116114544041559 0.400535367272073 2.632558389686389 0.0525855140687992 0.13564091059920247 2.006252482112114e-07 6.697614412946665 0.2565261584184776 LTPEEEEILNKK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTPEEEEILNKKR 13 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 5420800.0 1444900.0 1920700.0 2055200.0 True False 1201498.369923234 1910352.8078708993 2484932.817828856 1.0 1.5899753638391998 2.0681949139786373 20.196403260484203 -6.973514653921394 0.15239751735191864 0.4623889461790733 3.2083849283948633 0.99999843921453 0.0005457742169477755 0.07517786894027292 0.004668965769708295 0.02383190841219762 0.0590834473491112 1.0628827189871958e-07 6.973514653921394 2.74599598221579 LTPEEEEILNKK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTPEEEEILNKKR 13 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 110874600.0 15488200.0 17517400.0 77869000.0 True False 20049780.21806517 16542541.290967843 63697641.00341195 1.0 0.8250734477409758 3.176974525936168 24.25708308642563 -6.888983593398206 1.02834178841055 0.8705337909577575 3.37530305931872 0.9802409854373789 0.15038567763683805 0.11997310605166894 0.22667845688953062 0.11157052950590335 0.27715773364522867 1.2912680536959186e-07 6.888983593398206 2.5047692683609624 up LTPEELER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTPEELER 8 0 Q5H8X8;O95399;O95399-2 Q5H8X8 UTS2 Urotensin-2 0 22353600.0 7331400.0 2058200.0 12964000.0 False True 7098668.7200054675 2880049.9933712054 9568339.48833649 1.0 0.4057169177728563 1.3479061871659115 22.759117057162356 -6.7362435732269645 1.7005533521693064 0.6448676904966604 1.3480056869695358 0.5878926321960959 0.24972475838092825 0.32466803320576226 1.8420433547704693 0.11624579499324676 0.28643000479944003 1.8355086131300504e-07 6.7362435732269645 0.7031379964728754 LTPFMLGALVAMYEHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTPFMLGALVAMYEHK 16 0 P06744;A0A2U3TZU2;P06744-2 P06744 GPI Glucose-6-phosphate isomerase 0 16016600.0 4780000.0 6366800.0 4869800.0 False True 6187804.227886485 6012481.983132998 3983546.3683675905 1.0 0.9716664848633438 0.6437738205121296 22.560996122296444 -6.923923816139369 0.7950840654610516 1.0062637612589085 0.5858122786228753 0.9952032536242886 0.011196522780252982 0.09591779948130301 0.09405155686507492 0.00985313722885113 0.03071921031569423 1.1914509938177521e-07 6.923923816139369 -0.42045148263603316 LTPITYPQGLAMAK(ub)EIGAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTPITYPQGLAMAKEIGAVK 20 1 P63000-2;P63000 P63000-2 RAC1 Ras-related C3 botulinum toxin substrate 1 1 26316900.0 11388000.0 12318000.0 2610900.0 True False 15598451.349128393 11773750.029821226 1994259.193173388 1.0 0.7548024971388662 0.12784981973770254 23.894899466258117 -7.198172268754904 0.609172239362719 1.0012927923887658 1.4164434014204908e-21 0.9978357229871184 0.017085016531407038 0.08729890597054864 0.05629086801107474 0.016573875630273995 0.053285705518207424 6.336183281601554e-08 7.198172268754904 -1.0012927923887658 down LTPK(ub)IGFPWSEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTPKIGFPWSEIR 13 1 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 1 8579800.0 2675300.0 3419900.0 2484600.0 True False 3507344.207642051 2909664.2506657913 2227517.4259661194 1.0 0.829591873054834 0.6351008894743339 21.741947591671426 -6.969400831330695 0.27211653147867226 1.0471252565005174 0.4117039197019511 0.999977323375988 0.0007098834854807707 0.07649760646564983 0.009723816062771536 0.003763680428229445 0.018036605127405087 1.0729986329853406e-07 6.969400831330695 -0.6354213367985663 LTPK(ub)IGFPWSEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTPKIGFPWSEIR 13 1 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 1 9812200.0 3786200.0 4056500.0 1969500.0 True False 3666009.1534610954 5676281.604368048 1453628.866266486 1.0 1.5483544548733723 0.39651534009240225 21.80577895739413 -6.777246551430753 1.5464823080046786 1.3116102204900595 0.38815231964634245 0.7575288146231469 0.23163917981976023 0.25489694744982333 1.2038820994815007 0.11799353061053587 0.27907632138860683 1.6701421959654886e-07 6.777246551430753 -0.923457900843717 down LTPK(ub)IGFPWSEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTPKIGFPWSEIR 13 1 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 1 7849700.0 2675300.0 2936900.0 2237500.0 True False 3664430.7072640625 2807138.0469704457 1709048.5827589913 1.0 0.7660502466060577 0.46638856599774575 21.805157653194318 -6.967748463146256 0.3072449041216962 1.0476933895935783 0.17525788481619284 0.9999591108127777 0.0013965128393998907 0.077040256038633 0.011631688289308576 0.004801467250122362 0.02667624655002483 1.0770888667329384e-07 6.967748463146256 -0.8724355047773854 down LTPK(ub)IGFPWSEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTPKIGFPWSEIR 13 1 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 1 10321000.0 3786200.0 5391100.0 1143700.0 True False 3148393.05709969 5362057.074250432 1382842.3821286801 1.0 1.7031091661693525 0.4392216464238296 21.586184232828405 -6.7556990858398125 1.6284988202130097 1.4105787915264831 0.43553477041479466 0.6732300808737173 0.2955764578337952 0.2902031231953198 1.515767687313091 0.1432734921334924 0.3458088888087524 1.755096152471467e-07 6.7556990858398125 -0.9750440211116884 LTPK(ub)IGFPWSEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTPKIGFPWSEIR 13 1 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 1 16352300.0 7516800.0 6819400.0 2016100.0 True False 9730645.778279724 6439894.395265619 1649190.486932912 1.0 0.6618157254927972 0.16948417653987108 23.214104122553167 -7.388232435397666 0.46039106446787964 1.0192807934252992 7.41621582697624e-29 0.998580060963674 0.01284950452006211 0.10976677178640537 0.04963173620866712 0.016117745301146832 0.060906386704968604 4.090416810952526e-08 7.388232435397666 -1.0192807934252992 down LTPK(ub)LGDFGLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTPKLGDFGLAR 12 1 D3YTB5;P51617-4;P51617-2;P51617-3;P51617;H7C224;H7C2I6 D3YTB5 IRAK1 Interleukin-1 receptor-associated kinase 1 1 4331850.0 457180.0 782170.0 3092500.0 True False 442667.07114767947 1094494.5599626654 2282481.4769886346 1.0 2.4725005117842342 5.156203444432778 18.75586253353142 -6.961820366442197 0.4089700745591542 0.8663047784767893 6.861827360936081 0.9998318694649014 0.022310340203855496 0.07905714103306868 0.01877497716927134 0.03454849827531341 0.22414437321889646 1.0918918730712711e-07 6.961820366442197 5.995522582459292 LTPK(ub)LGDFGLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTPKLGDFGLAR 12 1 D3YTB5;P51617-4;P51617-2;P51617-3;P51617;H7C224;H7C2I6 D3YTB5 IRAK1 Interleukin-1 receptor-associated kinase 1 1 4219980.0 457180.0 2343700.0 1419100.0 True False 380165.42650806525 2331074.0229119766 1715827.24882295 1.0 6.1317359769498205 4.513370046780276 18.536267808965697 -9.888392583683201 6.6996129002268345 0.9999998456876135 5.322553011865158 0.9048694540566085 0.66069512433707 1.5231346289256587e-06 2.504204900802576e-07 0.639715341495584 0.21323843445643428 1.2930264722335613e-10 9.888392583683201 4.322553166177545 LTPLILKPFGNSISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTPLILKPFGNSISR 15 1 Q14739;C9JXK0;A0A494C1L1 Q14739 LBR Lamin-B receptor 0 22076700.0 7448000.0 5624300.0 9004400.0 False True 9764400.126534604 4785176.36334969 8072711.064303848 1.0 0.4900635268259899 0.8267493097058142 23.219099984551754 -10.137567820470178 7.37921360881308 1.0000001477196723 0.6584064182659021 0.5785015719064392 0.13745139528417566 3.3412530660316185e-07 3.896845591561172e-08 0.13308679872257612 0.04436224707071539 7.28504400631599e-11 10.137567820470178 -0.3415937294537702 LTPLILKPFGNSISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTPLILKPFGNSISR 15 1 Q14739;C9JXK0;A0A494C1L1 Q14739 LBR Lamin-B receptor 0 12853800.0 4578800.0 1899700.0 6375300.0 False True 4433448.500308405 2658260.11680463 4705417.675099638 1.0 0.5995919692356216 1.0613448368177312 22.079997886359497 -6.677414424378089 1.911282823893352 0.7460696145754988 1.059545313091128 0.31226379634568124 0.16979943913803014 0.4442777045388561 3.13557902543563 0.07134928226128223 0.18879014173265635 2.101771872203531e-07 6.677414424378089 0.3134756985156293 LTPLILKPFGNSISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTPLILKPFGNSISR 15 1 Q14739;C9JXK0;A0A494C1L1 Q14739 LBR Lamin-B receptor 0 18039400.0 7448000.0 5701100.0 4890300.0 False True 10201726.874631917 5449206.5509834215 3735311.8588899686 1.0 0.5341455047707334 0.3661450561059782 23.282310046074645 -13.999999999999979 0.14194287799565755 3.2294232269879015 0.1630229974823339 0.999595302632667 0.0053938816733378955 11.936505836735105 0.11817858558386428 7.363178249741279 0.18183627140014436 1.000000000000049e-14 13.999999999999979 -3.0664002295055677 LTPLILKPFGNSISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTPLILKPFGNSISR 15 1 Q14739;C9JXK0;A0A494C1L1 Q14739 LBR Lamin-B receptor 0 7924200.0 4578800.0 1992800.0 1352600.0 False True 3807475.075233236 1982064.3908601685 1635422.4062842096 1.0 0.5205718623748975 0.42952937943632574 21.860403161793773 -13.999999999999995 0.233598026886333 4.077756792103149 0.3867523954393281 0.9995149130062959 0.005511437366853594 13.406016162981809 0.1530088077962553 19.17625329248634 0.04622393699718903 1.0000000000000123e-14 13.999999999999995 -3.6910043966638213 LTPLSHEVISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTPLSHEVISR 11 0 P41091;Q2VIR3;Q2VIR3-2;H7BZU1 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 4930500.0 2280500.0 0.0 2650000.0 False True 2208106.7757825865 0.0 1955885.5017040798 1.0 0.0 0.8857748742747661 21.074378506461745 -9.11207921812253 12.542219841983979 0.9999999963302314 0.442887437137381 0.3453123311054287 0.361616078158519 0.0 0.0 0.3501332621071948 0.11671108736906491 7.725396560128376e-10 9.11207921812253 -0.5571125591928504 LTPQMFQQLMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTPQMFQQLMK 11 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 17882300.0 3227900.0 5527300.0 9127100.0 False True 4231808.159028067 4702648.385246649 8182715.245325348 1.0 1.1112621859320584 1.9336215012177438 22.01284279642353 -6.931599619440612 0.7335424373396354 0.9882072892102419 2.109537519290563 0.9968434422644608 0.02339322531461016 0.09181550952706671 0.07367293278599003 0.021518913632804858 0.07376557444822678 1.1705780617055641e-07 6.931599619440612 1.121330230080321 LTPQMFQQLMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTPQMFQQLMK 11 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 12670600.0 3227900.0 3694000.0 5748700.0 False True 4421341.860717557 3530786.8655755455 4390975.458192901 1.0 0.7985781187710556 0.9931318582726086 22.076052857946422 -10.669939579575514 8.31078153173258 1.0001881821498484 0.8958549885292357 0.27644468809186085 0.07942623155486078 0.00027743714228910526 1.1018385422880266e-05 0.0770420903948369 0.025634706005332495 2.1382595502541174e-11 10.669939579575514 -0.10433319362061266 LTPTEVK(ub)DYLAAIA ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTPTEVKDYLAAIA 14 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 2480060.0 1259700.0 604310.0 616050.0 True False 1651478.8989521512 514149.30358193 552307.055568876 1.0 0.3113265957610195 0.33443179680909635 20.65532710566177 -10.129145186740907 5.210213923816046 1.00001964835895 0.3228791962845153 0.9991274917849063 0.009432658830931199 2.1529337706476804e-06 3.5983309732286447e-07 0.009133397096504965 0.0030443775465667003 7.427707845287811e-11 10.129145186740907 -0.6771404520744349 LTPTEVK(ub)DYLAAIA ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTPTEVKDYLAAIA 14 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 114598900.0 5892900.0 24580000.0 84126000.0 True False 8939960.128697196 20193506.955583457 67498459.22626439 1.0 2.258791612589241 7.550196897365896 23.091836966475597 -6.9437355746940534 0.623842478682837 0.942209905426372 9.14896198876593 0.9986133967678561 0.1056792497908597 0.08610299650365884 0.04715395751652666 0.1060570372179429 0.44847089590140904 1.1383201544928585e-07 6.9437355746940534 8.206752083339557 LTPTEVK(ub)DYLAAIA ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTPTEVKDYLAAIA 14 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 87266900.0 5892900.0 23857000.0 57517000.0 True False 7628475.216425149 22529336.97801158 47049496.174257345 1.0 2.9533211210417045 6.167614738126613 22.862963288568046 -6.963672504203064 0.3801472510168935 0.7795742772224546 8.455053873983205 0.9998831118587185 0.0230338944023576 0.07841436794341985 0.016466352316771595 0.04182456874442424 0.27158568488123436 1.0872451919652198e-07 6.963672504203064 7.67547959676075 LTPTMMLYAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTPTMMLYAGR 11 0 O14874;O14874-2;O14874-3;H3BNP3;H3BTL2;H3BS02 O14874 BCKDK [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 0 4759400.0 1293900.0 1542200.0 1923300.0 False True 1696315.4301454232 1312109.7714485165 1724295.3655963296 1.0 0.7735057691104248 1.0164945357176334 20.693973033561253 -11.065148176362527 11.873211961430865 1.62331384787205 0.8950001524140282 0.1993390289130318 0.0991997485693155 0.04051536822499918 0.0002223077071352823 0.0023775508436248453 0.03201658117974351 8.607000409681215e-12 11.065148176362527 -0.7283136954580217 LTPVSPESSSTEEK(ub)SSSQPSSCCSDPSKPGGNVEGATQSLAEQMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNVEGATQSLAEQMR 45 2 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 73994000.0 15007000.0 25963000.0 33024000.0 True False 19674322.327994734 22089421.60298135 29606993.268576525 1.0 1.122753873537497 1.5048545395867854 24.22981060790471 -6.950618291490883 0.5520123704813369 0.9947776098851587 1.650843457854905 0.9992489259143199 0.005891680739955481 0.08323837844425751 0.03494195040017389 0.006378283146763969 0.031710717633822 1.1204222082016444e-07 6.950618291490883 0.6560658479697462 LTPVSPESSSTEEK(ub)SSSQPSSCCSDPSKPGGNVEGATQSLAEQMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNVEGATQSLAEQMR 45 2 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 39425200.0 23612000.0 10734000.0 5079200.0 True False 22862449.98455533 15020142.177070536 3748805.14726618 1.0 0.6569786784538557 0.16397215301941287 24.446476678051557 -7.408056607690753 0.46288612589674 1.0191723687308065 6.50370756619818e-23 0.998440323261543 0.013551257764776588 0.11133472539844044 0.05205627935093222 0.016911341551275185 0.0623000421368833 3.907899553369222e-08 7.408056607690753 -1.0191723687308065 down LTPVSPESSSTEEK(ub)SSSQPSSCCSDPSKPGGNVEGATQSLAEQMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 LTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNVEGATQSLAEQMR 45 2 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 882329000.0 105517000.0 501117000.0 275695000.0 True False 160077003.32599273 411688756.10500795 221203762.40858895 1.0 2.571816985270609 1.3818584669411453 27.254190824163864 -6.57543613792181 2.2854704362691804 2.0733003598653283 1.3846208705950618 0.0 0.6836343031456522 0.7130573182374493 6.999467338837426 0.2519298619782917 0.7648856315007544 2.658054382051291e-07 6.57543613792181 -0.6886794892702666 LTPVSPESSSTEEK(ub)SSSQPSSCCSDPSKPGGNVEGATQSLAEQMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNVEGATQSLAEQMR 45 2 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 81954000.0 15007000.0 32894000.0 34053000.0 True False 20555493.448926043 31440634.31408826 26010382.743549462 1.0 1.529548993421558 1.2653737945127472 24.2930206694276 -10.037182843893683 4.345977687943325 0.9999751657857112 1.3974613938099327 0.7511308562317949 0.10784907356691012 33157938.079614345 43411435.10497629 10786.558914469499 0.039468722478969334 9.179460473260932e-11 10.037182843893683 0.3974862280242215 LTPVSPESSSTEEK(ub)SSSQPSSCCSDPSKPGGNVEGATQSLAEQMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNVEGATQSLAEQMR 45 2 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 54519300.0 23612000.0 3522300.0 27385000.0 True False 19634424.18895935 3503324.670778188 33111076.886066165 1.0 0.1784276756508167 1.6863788093508179 24.226881953485833 -6.758779508276731 1.6173017677210642 0.522058206042627 1.6915125410349794 0.6858785873413631 0.3454947331165578 0.28497081434252963 1.4688478703439225 0.16858227902016 0.4055811835635991 1.742691414927176e-07 6.758779508276731 1.1694543349923525 LTPVSPESSSTEEK(ub)SSSQPSSCCSDPSKPGGNVEGATQSLAEQMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LTPVSPESSSTEEKSSSQPSSCCSDPSKPGGNVEGATQSLAEQMR 45 2 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 809586000.0 105517000.0 511084000.0 192985000.0 True False 136593836.55102462 482641726.12105674 157863710.19331792 1.0 3.533407789895161 1.1557162034492525 27.025317146256313 -6.631190338519437 2.075960481789697 2.6675726519810676 1.1652891537747754 0.1218714839803936 1.0863641875297485 0.5558966851779602 4.5669161228673 0.42776075109272077 1.203496518441762 2.3378124195622753e-07 6.631190338519437 -1.5022834982062923 LTQAQIFDYGEIPNFPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTQAQIFDYGEIPNFPR 17 0 P00491;G3V5M2;G3V2H3 P00491 PNP Purine nucleoside phosphorylase 0 4337600.0 1675500.0 0.0 2662100.0 False True 1622312.1696223326 0.0 1964816.1487118641 1.0 0.0 1.2111208838242673 20.629620022808464 -10.756794809278839 6.239438376643604 1.0119816509397683 0.6055604419121337 0.12390176256640628 0.49443803036634 0.0824692022361347 0.003214538533002404 0.4790859943610986 0.15957918811170263 1.750673632444678e-11 10.756794809278839 -0.4064212090276347 LTQECGEDLSK(ub)QEVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTQECGEDLSKQEVDK 16 1 Q9NVU0-4;Q9NVU0;A0A0C4DH01;Q9NVU0-5 Q9NVU0-4 POLR3E DNA-directed RNA polymerase III subunit RPC5 1 16720500.0 1999300.0 3585200.0 11136000.0 True False 3033084.2684084764 2945393.0487045436 8934964.718917813 1.0 0.9710884327820057 2.9458346449458124 21.532354150347963 -6.90357843703392 0.9383652764828219 0.9257623341758032 3.1688664057630764 0.9882641374442721 0.10011683041783107 0.10881907549491622 0.16293573896119815 0.07944890970686252 0.210683130264235 1.2485949180627258e-07 6.90357843703392 2.243104071587273 up LTQEETNFK(ub)SLVHDLFQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTQEETNFKSLVHDLFQK 18 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 15984300.0 6085900.0 3677100.0 6221300.0 True False 5892706.43575324 5145385.205823179 4591754.89500061 1.0 0.873178608492053 0.7792268196393979 22.490498964780212 -6.974415815594582 0.1097709464575703 1.1981585592580974 0.45184939454661976 0.9999996181667788 5.5600311601332935e-05 0.07489409431186378 0.003243928573723552 0.007481596822602443 0.014404789434776456 1.0606795224285208e-07 6.974415815594582 -0.7463091647114777 LTQEETNFK(ub)SLVHDLFQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTQEETNFKSLVHDLFQK 18 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 16612700.0 6085900.0 6396200.0 4130600.0 True False 5060695.501083682 6361742.401053707 4994289.362263462 1.0 1.2570885562451688 0.986878060771291 22.270904240214488 -6.6574230049090115 1.9818484784864439 1.1658322045419596 0.9880043308012857 0.22479493393251193 0.10952974703653891 0.4905754475158045 3.7012465756986246 0.04469129855910707 0.1214017452290667 2.2007818467121945e-07 6.6574230049090115 -0.17782787374067388 LTQGVVK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTQGVVKR 8 1 F8W8D4;Q8TBC4-2;Q8TBC4 F8W8D4 UBA3 NEDD8-activating enzyme E1 catalytic subunit 1 3969200.0 1018800.0 1412700.0 1537700.0 True False 1335656.6660732348 1201930.6666614707 1378593.554659946 1.0 0.8998799595670705 1.0321466509151214 20.349117776379792 -6.70423703889405 1.8154927305347497 0.9380911255749389 1.0317898482770862 0.43785751004807394 0.04222984743834171 0.3867581730132997 2.4810788437915186 0.018535666668024933 0.047425828188153676 1.9758909001018353e-07 6.70423703889405 0.0936987227021473 LTQGVVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTQGVVKR 8 1 F8W8D4;Q8TBC4-2;Q8TBC4 F8W8D4 UBA3 NEDD8-activating enzyme E1 catalytic subunit 1 4119000.0 1207600.0 1393000.0 1518400.0 True False 1169265.3990068191 1949232.1643990348 1120685.4889764066 1.0 1.6670570822113817 0.9584526232695533 20.157170998230253 -6.659856351070259 1.973922685928696 1.4294450494952324 0.961441139009561 0.23476606722857007 0.284031070930551 0.48479266244222824 3.6312192124997975 0.11627331588695694 0.3147534660451078 2.1884853761710463e-07 6.659856351070259 -0.46800391048567147 LTQGVVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTQGVVKR 8 1 F8W8D4;Q8TBC4-2;Q8TBC4 F8W8D4 UBA3 NEDD8-activating enzyme E1 catalytic subunit 1 4670500.0 1321400.0 1455700.0 1893400.0 True False 2004660.4072800316 1195918.9615639863 1519168.6600933 1.0 0.5965693527047985 0.7578184587156795 20.934926431825797 -10.107196847790824 5.145452980557415 1.0000082236588286 0.6771939057096954 0.8423588512306474 0.06582967186966249 6.210431008639999e-06 1.0776805548153923e-06 0.06374092925589987 0.021246435236186294 7.812736051944339e-11 10.107196847790824 -0.3228143179491332 LTQGVVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTQGVVKR 8 1 F8W8D4;Q8TBC4-2;Q8TBC4 F8W8D4 UBA3 NEDD8-activating enzyme E1 catalytic subunit 1 3746000.0 1018800.0 1171700.0 1555500.0 True False 1395477.892034774 1119930.4197062447 1188122.9365280967 1.0 0.8025425741953188 0.8514093582634055 20.412327837902684 -10.857590649300192 7.238382339841187 1.016117329735826 0.8269759662311048 0.9435528299211282 0.019949781056263112 0.005292471395503283 0.0001041249801596534 0.019701882519602837 0.006438764149282603 1.3880635523392296e-11 10.857590649300192 -0.1891413635047211 LTQGVVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTQGVVKR 8 1 F8W8D4;Q8TBC4-2;Q8TBC4 F8W8D4 UBA3 NEDD8-activating enzyme E1 catalytic subunit 1 3361360.0 1207600.0 1448300.0 705460.0 True False 1004172.9057507755 1440497.7204349576 852968.4243214993 1.0 1.4345116385688195 0.8494238586170304 19.93757627366453 -6.707866190130266 1.8032315861155748 1.2677149341661338 0.8509076653367389 0.454786818179034 0.18316347911660313 0.3793715797207084 2.4033996409859446 0.08088120084496887 0.2059773427198943 1.9594483034051925e-07 6.707866190130266 -0.4168072688293949 LTQGVVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTQGVVKR 8 1 F8W8D4;Q8TBC4-2;Q8TBC4 F8W8D4 UBA3 NEDD8-activating enzyme E1 catalytic subunit 1 3337620.0 1321400.0 609020.0 1407200.0 True False 1710578.3486881182 575127.5016283937 1151104.0390913112 1.0 0.3362181580688614 0.6729326604502619 20.706052753918247 -10.60730307028032 6.624136403179328 1.001240793562838 0.5045754092598213 0.7426984919650748 0.13746311997159708 0.002524336690638916 0.00014964915331846628 0.13338354348316447 0.044366031197308975 2.4699998661190368e-11 10.60730307028032 -0.49666538430301677 LTQILSYLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTQILSYLR 9 0 Q13123 Q13123 IK Protein Red 0 12755000.0 3315000.0 4290300.0 5149700.0 False True 4345997.102505669 3650203.963458419 4616858.443410502 1.0 0.8399002294212086 1.0623243261595063 22.05125578199291 -6.713522565459777 1.7823125408012346 0.9019319870927772 1.0618655620408903 0.4819473921481412 0.06742923948610512 0.3680496403607212 2.28110752109133 0.03008026878123123 0.0761029743388457 1.934093362661679e-07 6.713522565459777 0.1599335749481131 LTQILSYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTQILSYLR 9 0 Q13123 Q13123 IK Protein Red 0 15562500.0 3315000.0 4365500.0 7882000.0 False True 4540645.0845065545 4172617.7752219955 6020433.934885539 1.0 0.9189482325891688 1.3258983740940848 22.114465843515802 -6.854931765814969 1.2110109171160062 0.9564890212017579 1.343786352095338 0.9471837628957519 0.04041916889628043 0.15211555930120055 0.42681310386624244 0.026079575092906378 0.06057351256677861 1.396587768730789e-07 6.854931765814969 0.38729733089358 LTQILSYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTQILSYLR 9 0 Q13123 Q13123 IK Protein Red 0 10766000.0 5340200.0 2866400.0 2559400.0 False True 4440612.910972425 2850958.1342641474 3094558.706671456 1.0 0.6420190616524223 0.6968764827542232 22.082327386123477 -10.39106709631469 5.876522595026377 1.0000872633981819 0.6694477722033553 0.9797617767653057 0.022395448384067648 2.5611088657721944e-05 2.653878647838911e-06 0.02168999363179266 0.007228099885194971 4.0638054056402825e-11 10.39106709631469 -0.3306394911948266 LTQK(ub)ADYATAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTQKADYATAK 11 1 Q5SPY9;Q9NQX5 Q5SPY9 NPDC1 Neural proliferation differentiation and control protein 1 1 54746200.0 12656000.0 22595600.0 19494600.0 True False 16592138.560878338 19224424.556958977 17477485.797407683 1.0 1.1586465774994885 1.053359440875021 23.98399651146575 -10.255098150687566 3.9482064608179432 0.99987886606321 1.106003009203606 0.5747442752254385 0.04298329358918516 30379547.164190035 6.967739742144893 33534.18750447344 0.014714324676289482 5.557786369315514e-11 10.255098150687566 0.10612414314039598 LTQK(ub)ADYATAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTQKADYATAK 11 1 Q5SPY9;Q9NQX5 Q5SPY9 NPDC1 Neural proliferation differentiation and control protein 1 1 32791700.0 8390500.0 10131900.0 14269300.0 True False 8124148.170227487 14177620.507160489 10531742.26017587 1.0 1.745120868070467 1.2963503421529754 22.953785121427842 -10.264280944237933 4.529608361072903 0.9997680342788036 1.5207356049994978 0.6422500846629942 0.1832098001225793 0.0004482288103476805 7.280291011472753e-05 0.177473458668716 0.05913070871218494 5.441505290639216e-11 10.264280944237933 0.5209675707206942 LTQK(ub)ADYATAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTQKADYATAK 11 1 Q5SPY9;Q9NQX5 Q5SPY9 NPDC1 Neural proliferation differentiation and control protein 1 1 26800300.0 8183600.0 10199600.0 8417100.0 True False 12415119.501299271 8379401.69016147 6753456.495654007 1.0 0.6749352424102358 0.5439703173978504 23.565594812403866 -13.999999999999998 0.12526018864085545 2.5452545559199455 0.34902410552659435 0.9996675705826044 0.003495415423909334 11.946655116193435 0.10956483357604709 4.566472371424327 0.17312572071163743 1.0000000000000041e-14 13.999999999999998 -2.196230450393351 LTQK(ub)ADYATAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTQKADYATAK 11 1 Q5SPY9;Q9NQX5 Q5SPY9 NPDC1 Neural proliferation differentiation and control protein 1 1 40754800.0 12656000.0 14064200.0 14034600.0 True False 17335265.21553994 13442797.13991003 10719916.531660046 1.0 0.7754595601952161 0.6183878007271754 24.047206572988642 -7.470403586101218 0.09348248532966419 1.4677430985650848 6.5751955651619655e-09 0.999998192040431 0.000210488556165586 0.1305807899647772 0.007610672466255759 0.0480912873332102 0.06797288927011177 3.3852941746376856e-08 7.470403586101218 -1.4677430919898893 LTQK(ub)ADYATAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTQKADYATAK 11 1 Q5SPY9;Q9NQX5 Q5SPY9 NPDC1 Neural proliferation differentiation and control protein 1 1 33949600.0 8390500.0 16433900.0 9125200.0 True False 6977072.51217446 16345367.318826262 11033237.129842276 1.0 2.342725733508551 1.5813562365290195 22.734190396862118 -10.252040220138744 5.666147914842124 0.9999443946730989 1.9620409850187892 0.6803886856992656 0.3108277955532932 0.00021836207083982838 2.8824911517481314e-05 0.3009749546437074 0.1003192396430125 5.597057645805901e-11 10.252040220138744 0.9620965903456903 LTQK(ub)ADYATAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTQKADYATAK 11 1 Q5SPY9;Q9NQX5 Q5SPY9 NPDC1 Neural proliferation differentiation and control protein 1 1 22073800.0 8183600.0 6812500.0 7077700.0 True False 10593831.522872768 6433378.386331205 5789631.223334701 1.0 0.6072758824265918 0.5465096561932774 23.336721134496315 -13.999999999998872 0.26269574287667935 3.915789032508402 0.5248668445454647 0.9995678821088264 0.004178095932038037 14.537893922704402 0.16220117005649745 22.53911694876406 0.026194058959456347 1.0000000000025972e-14 13.999999999998872 -3.3909221879629374 LTQNVGLLGLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTQNVGLLGLLK 12 0 Q92608;E5RFJ0;F6S220;Q92608-2 Q92608 DOCK2 Dedicator of cytokinesis protein 2 0 1701240.0 482320.0 795820.0 423100.0 False True 632326.1907935237 677086.7580820642 379321.67066178244 1.0 1.0707871474252384 0.5998829025028382 19.270309451256 -6.868621764143958 1.1414299425466246 1.0397158212929425 0.5730252738535309 0.9632846086010258 0.03972620768540033 0.13817957517915808 0.33734313154865664 0.02703361318623326 0.06385133300406103 1.3532506234844073e-07 6.868621764143958 -0.46669054743941163 LTQNVGLLGLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTQNVGLLGLLK 12 0 Q92608;E5RFJ0;F6S220;Q92608-2 Q92608 DOCK2 Dedicator of cytokinesis protein 2 0 3275620.0 482320.0 1145000.0 1648300.0 False True 660646.7382079029 1094410.1139913371 1259005.4878040876 1.0 1.6565738551288067 1.9057166485364279 19.333519512778892 -10.765620515332799 0.19651243775504898 2.8678964666773807e-18 2.1146541968407386 0.9993998889233859 0.009358513659557042 2.672870469095168 0.1054788658928001 1.4087670556368377 0.15826653031975788 1.7154556106084547e-11 10.765620515332799 2.1146541968407386 LTQVMK(ub)EETR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTQVMKEETR 10 1 Q6NUQ1 Q6NUQ1 RINT1 RAD50-interacting protein 1 1 3071080.0 984440.0 687040.0 1399600.0 True False 1290610.3733305219 584536.3100609443 1254782.817911205 1.0 0.4529146225227543 0.9722398361584055 20.29962209568243 -10.724329053608223 9.999848026728092 1.0005033309106874 0.71257722934058 0.289982275191764 0.21201363066153506 0.002382947351008375 6.569195832755153e-05 0.20561319559748187 0.06842710506009131 1.886561409047742e-11 10.724329053608223 -0.28792610157010745 LTQVMK(ub)EETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTQVMKEETR 10 1 Q6NUQ1 Q6NUQ1 RINT1 RAD50-interacting protein 1 1 5647980.0 875980.0 1007700.0 3764300.0 True False 848172.4943872096 1410079.865086078 2778316.9034206336 1.0 1.6624918568066003 3.2756507925052682 19.69399817258621 -6.956024281187448 0.4882567838369782 0.9641330762098155 4.042212253754003 0.9995931280579066 0.019276903097321003 0.08115320563079337 0.0266212845120498 0.023139478315115286 0.13304915384853602 1.1065619149244812e-07 6.956024281187448 3.078079177544187 LTQVMK(ub)EETR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTQVMKEETR 10 1 Q6NUQ1 Q6NUQ1 RINT1 RAD50-interacting protein 1 1 20514510.0 440510.0 5396000.0 14678000.0 True False 668285.8755947681 4433041.640859573 11776886.866404045 1.0 6.63345104655131 17.62252846646314 19.350105857190815 -6.960530179034525 0.4278956202208985 0.5536283627567937 24.12230440321399 0.9997893615152608 0.10017908085503087 0.07951225644865138 0.02043547994882054 0.1430159318914262 0.9128881202737313 1.0951404516370492e-07 6.960530179034525 23.5686760404572 LTQVMK(ub)EETR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTQVMKEETR 10 1 Q6NUQ1 Q6NUQ1 RINT1 RAD50-interacting protein 1 1 7170480.0 875980.0 2742200.0 3552300.0 True False 728416.1824938433 2727427.224315918 4295069.506020551 1.0 3.7443254143231104 5.8964498719890175 19.474403448020485 -7.803861374499387 0.25827552560211015 5.380873477693243e-22 7.856628426812736 0.9996457974413951 0.0377127101850867 0.12736662623665354 0.04100396610169446 0.3434390066770273 0.6144303877915468 1.5708641394553052e-08 7.803861374499387 7.856628426812736 LTQVMK(ub)EETR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LTQVMKEETR 10 1 Q6NUQ1 Q6NUQ1 RINT1 RAD50-interacting protein 1 1 31094290.0 1030230.0 8117060.0 21947000.0 True False 1333653.0438693503 7665338.475530798 17952871.195236683 1.0 5.747625674284236 13.461425576737494 20.34695196073879 -6.963895446860442 0.3765292974922293 0.44901923700738555 19.031315308816836 0.9998885330883919 0.05421604719905807 0.07833781934382303 0.016194042355343035 0.10077610179859084 0.6529162808681257 1.0866872039238659e-07 6.963895446860442 18.582296071809452 LTQVYK(ub)NVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTQVYKNVR 9 1 Q14997;Q14997-2;Q14997-3 Q14997 PSME4 Proteasome activator complex subunit 4 1 2568690.0 664470.0 699320.0 1204900.0 True False 871126.6047366331 594984.1819280102 1080228.5062169281 1.0 0.6830054078165724 1.2400361788324816 19.732522881839863 -6.752351088743367 1.641301219273626 0.8141318638428436 1.2413346528638958 0.6589769420300874 0.13322099448307265 0.2959545908845164 1.5693343803615407 0.06410242277884735 0.1552315283792491 1.768678559766581e-07 6.752351088743367 0.42720278902105213 LTQVYK(ub)NVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTQVYKNVR 9 1 Q14997;Q14997-2;Q14997-3 Q14997 PSME4 Proteasome activator complex subunit 4 1 4155610.0 893510.0 1242100.0 2020000.0 True False 865146.0141326472 1738077.0074659307 1490901.401298959 1.0 2.008998456992767 1.7232945386608103 19.722584117114064 -9.993426233274825 5.591191767999507 0.9999979599331702 1.8661464978275055 0.9245528736162226 0.11663813624037704 2.9661420740763204e-06 5.340968082373894e-07 0.1129346556079024 0.037644796598936915 1.0152517966711782e-10 9.993426233274825 0.8661485378943353 LTQVYK(ub)NVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTQVYKNVR 9 1 Q14997;Q14997-2;Q14997-3 Q14997 PSME4 Proteasome activator complex subunit 4 1 9751900.0 2733900.0 4022300.0 2995700.0 True False 4147526.1748621752 3304489.1386266616 2403598.581938049 1.0 0.7967373801411806 0.5795258379575922 21.983819655321394 -6.970281453061525 0.25137075691314553 1.0677807380865443 0.3021095062612817 0.9999844949844132 0.0006760263114064437 0.0762114693008186 0.008702670530188288 0.004799972513060987 0.020771362897472133 1.070825111091884e-07 6.970281453061525 -0.7656712318252625 LTQVYK(ub)NVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTQVYKNVR 9 1 Q14997;Q14997-2;Q14997-3 Q14997 PSME4 Proteasome activator complex subunit 4 1 9013400.0 2733900.0 3946300.0 2333200.0 True False 3539087.443225705 3726684.9359235056 1908581.5406536756 1.0 1.0530073064616947 0.5392863474755224 21.754945977413843 -6.881447584617184 1.0717352654249042 1.0335226643698172 0.5018595682908319 0.974832673698345 0.03659773322993881 0.12635360208352425 0.26462604811243506 0.026270676872556124 0.0637671277249213 1.3138700575236304e-07 6.881447584617184 -0.5316630960789853 LTSADALRPSVVSITGPLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTSADALRPSVVSITGPLIR 20 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 5856200.0 1371100.0 2585000.0 1900100.0 False True 1797525.3777512882 2199328.076251078 1703495.8790462161 1.0 1.2235310296439021 0.9476894736124931 20.77758070833227 -6.691132495498202 1.8622764596685262 1.1399920858813128 0.9486274759864811 0.37572982118802645 0.0945165642110777 0.41426933196588606 2.786386537277219 0.040587478221872086 0.10554648179648356 2.0364207072999103e-07 6.691132495498202 -0.19136460989483173 LTSADALRPSVVSITGPLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTSADALRPSVVSITGPLIR 20 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 7522800.0 1371100.0 2084000.0 4067700.0 False True 1878032.722584294 1991921.9891335808 3106993.0369111774 1.0 1.0606428552493845 1.6543870612838711 20.84079076985516 -6.926541466182512 0.7746414418674884 0.9897204986740546 1.766201533963622 0.9958141686704548 0.019100612059753302 0.09447304869344213 0.08676787665269367 0.017056286541755804 0.05478034320120855 1.184291286161134e-07 6.926541466182512 0.7764810352895672 LTSFIGAIAIGDLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTSFIGAIAIGDLVK 15 0 P78371;F5GWF6;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 183554000.0 96392000.0 47411000.0 39751000.0 False True 93332088.7223132 66342459.54509884 29339020.595561862 1.0 0.7108215454438677 0.3143508411437458 26.475869846910996 -7.049871137815326 0.3419635114526454 1.0445070973489192 5.675442689640916e-15 0.9999326637734343 0.0023062934832323075 0.0730466753035043 0.013950428777616819 0.005881939420397627 0.03273182101978928 8.915154259137221e-08 7.049871137815326 -1.0445070973489134 down LTSFIGAIAIGDLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTSFIGAIAIGDLVK 15 0 P78371;F5GWF6;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 361390000.0 88520000.0 140100000.0 132770000.0 False True 134291311.67884675 115098060.39370395 106527951.30484168 1.0 0.8570774903811884 0.7932601891595175 27.000790728024256 -13.99999999825297 0.10909245926156554 1.6907410881476146 0.6746452448945491 0.9997476699710381 0.0013730170935310649 12.017991087698341 0.1000769220433084 1.8315801348762684 0.10537933169846361 1.0000000040226834e-14 13.99999999825297 -1.0160958432530656 LTSFIGAIAIGDLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTSFIGAIAIGDLVK 15 0 P78371;F5GWF6;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 181713000.0 96392000.0 37174000.0 48147000.0 False True 80154218.88963965 36973736.28353873 58214315.093424395 1.0 0.46128247265993605 0.7262788646668341 26.256275122345272 -10.217038136391277 4.799461422105393 1.0000709516950885 0.5937806686622943 0.7580532778868031 0.1081843240197025 152356551.2298705 15.067204706723318 119463.37639148955 0.03703437164570197 6.066830530235737e-11 10.217038136391277 -0.40629028303279424 LTSFIGAIAIGDLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTSFIGAIAIGDLVK 15 0 P78371;F5GWF6;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 264999000.0 88520000.0 110310000.0 66169000.0 False True 114590884.99006505 104171151.52971672 54126920.95127425 1.0 0.9090701371121122 0.47234927067686944 26.771917050116706 -6.9407066745289026 0.6529565175493226 1.0048486350643895 0.3520903676061225 0.9982549983750871 0.009621033473070322 0.08744572604063425 0.05315267360562238 0.009416276511849377 0.03747219962084064 1.1462868900768207e-07 6.9407066745289026 -0.652758267458267 down LTSFITVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTSFITVFK 9 0 Q5T2B5;A0A0A0MTN0;Q13617;Q13617-2 Q5T2B5 CUL2 Cullin-2 0 10156700.0 2847600.0 3046000.0 4263100.0 False True 3733231.176197627 2591548.6732150083 3821995.3065427733 1.0 0.6941838184943463 1.0237767569581786 21.8319934180207 -11.794836659122733 24.290951662673834 0.9051426445246769 0.8730822596714308 0.0 0.1536463434625184 0.0 0.0 0.0 0.04467287382409076 1.6038484947408366e-12 11.794836659122733 -0.03206038485324603 LTSFITVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTSFITVFK 9 0 Q5T2B5;A0A0A0MTN0;Q13617;Q13617-2 Q5T2B5 CUL2 Cullin-2 0 9404100.0 2988300.0 1581600.0 4834200.0 False True 2893438.0522127203 2213141.1279350417 3567977.997108631 1.0 0.7648828445601488 1.2331274880345424 21.46435332602187 -6.770159821458099 1.5736335729163375 0.8651742462658917 1.2357913643730123 0.7312745902923237 0.09909525645893237 0.26615574759926425 1.3007194072057506 0.049633798108763255 0.11814174903408962 1.6976188095191455e-07 6.770159821458099 0.3706171181071206 LTSFITVFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTSFITVFK 9 0 Q5T2B5;A0A0A0MTN0;Q13617;Q13617-2 Q5T2B5 CUL2 Cullin-2 0 8919700.0 1775800.0 2952400.0 4191500.0 False True 2694018.4283698187 2425521.1527935117 3363048.1878002905 1.0 0.9003357687724587 1.248338969171532 21.361328288879704 -6.830169969036513 1.3273891435747023 0.9467544871136632 1.2577200831410098 0.9061675061053311 0.04482384511108015 0.18060466421044755 0.6223310084966774 0.026514814109726604 0.061010184642279135 1.4785296254875079e-07 6.830169969036513 0.31096559602734664 LTSFITVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTSFITVFK 9 0 Q5T2B5;A0A0A0MTN0;Q13617;Q13617-2 Q5T2B5 CUL2 Cullin-2 0 10229600.0 2847600.0 2955700.0 4426300.0 False True 3900434.673496487 2825107.400807158 3380899.102510002 1.0 0.7243057857125017 0.8668005967343236 21.895203479543593 -10.252286259572237 5.099798661887983 1.0000314333212765 0.795553191223335 0.732958805611569 0.058173262999902525 2.0793874114002605e-05 3.0487051310185744e-06 0.05633467186772402 0.018775339899391435 5.593887661055176e-11 10.252286259572237 -0.20447824209794152 LTSFITVFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTSFITVFK 9 0 Q5T2B5;A0A0A0MTN0;Q13617;Q13617-2 Q5T2B5 CUL2 Cullin-2 0 6386400.0 2988300.0 1173700.0 2224400.0 False True 2484903.854136341 1167377.0451387905 2689511.755536445 1.0 0.4697876109756073 1.0823403694511224 21.244758601456148 -6.677770427759779 1.9097370712234494 0.6638600099141401 1.079973744890638 0.31397024852487954 0.22482688699019293 0.44350181461797045 3.125278140918151 0.0945309051482025 0.2500399090816794 2.1000496967369157e-07 6.677770427759779 0.41611373497649784 LTSFITVFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTSFITVFK 9 0 Q5T2B5;A0A0A0MTN0;Q13617;Q13617-2 Q5T2B5 CUL2 Cullin-2 0 9569400.0 1775800.0 4574200.0 3219400.0 False True 2298808.1062512174 4319641.748955044 2633502.2338335486 1.0 1.8790788744865277 1.1455946351816786 21.132454610972154 -10.128542666748624 4.238394201697599 0.9998998064441981 1.5123367548859226 0.39413447772229493 0.29944368698446694 42627603.00818828 33955938.71261943 36091.04612844729 0.10250753663505194 7.438019853700364e-11 10.128542666748624 0.5124369484417245 LTSK(ub)EECLSSQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTSKEECLSSQK 12 1 P49454;A0A087WTY4 P49454 CENPF Centromere protein F 1 2555340.0 1307500.0 825610.0 422230.0 True False 1714145.1618480112 702432.2062025742 378541.6899161536 1.0 0.40978571817411635 0.22083409173354357 20.709057858127263 -13.999999999999986 0.1593549441705552 3.902794655356258 0.033756919849452706 0.9995380792479883 0.007132358362668955 12.005451117432072 0.12612880837437673 10.771959937340162 0.1703671297615787 1.0000000000000327e-14 13.999999999999986 -3.8690377355068053 LTSK(ub)EECLSSQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTSKEECLSSQK 12 1 P49454;A0A087WTY4 P49454 CENPF Centromere protein F 1 3002670.0 1039100.0 858770.0 1104800.0 True False 864057.689935105 854143.6355575004 1335808.5719819572 1.0 0.988526166142507 1.545971510400287 19.720768113451456 -6.902204586671003 0.9472555374730888 0.9782039740897145 1.6071701617504992 0.9876305083490934 0.028930084751822654 0.10980027140177624 0.16842253311318628 0.022808000203347566 0.06002454920140493 1.25255098645211e-07 6.902204586671003 0.6289661876607847 LTSLGVIGALVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTSLGVIGALVK 12 0 Q92600;Q92600-3 Q92600 RQCD1 Cell differentiation protein RCD1 homolog 0 4038800.0 1650100.0 0.0 2388700.0 False True 2163297.0795911294 0.0 2141540.2380283624 1.0 0.0 0.989942739826155 21.04480036953975 -11.983373055513525 14.145727284848071 0.8685300981699444 0.5454742329217855 0.0 0.48362797870175844 0.0 0.0 0.0 0.13834052126081434 1.0390272662108519e-12 11.983373055513525 -0.3230558652481589 LTSLGVIGALVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTSLGVIGALVK 12 0 Q92600;Q92600-3 Q92600 RQCD1 Cell differentiation protein RCD1 homolog 0 4762800.0 1650100.0 0.0 3112700.0 False True 2260186.5622757934 0.0 2377544.368068787 1.0 0.0 1.0519239463466348 21.10801043106264 -10.52001225336557 5.035204394849299 1.0018154185567716 0.5259619731733064 0.21307394301183746 0.42944615279405374 0.008781538284846535 0.0008371111576612831 0.417215695587938 0.1386031498220122 3.019866515427169e-11 10.52001225336557 -0.4758534453834652 LTSLNK(ub)YIEEMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTSLNKYIEEMK 12 1 H0Y867;E7EU81;Q14789-4;Q14789-3;Q14789;Q14789-2 H0Y867 GOLGB1 Golgin subfamily B member 1 1 54335000.0 17959000.0 21409000.0 14967000.0 True False 27245115.978766512 17588396.680719525 12008765.889730858 1.0 0.6455614538189908 0.44076765535114226 24.699494296496326 -9.779452661523544 0.12064912064349792 1.7120210482466285 2.698407032050062e-15 0.9998825895737422 0.002503172805332624 1.290575564775971 0.0523535936912627 0.5214193265796355 0.22892365680659074 1.661679792439037e-10 9.779452661523544 -1.7120210482466258 LTSLNK(ub)YIEEMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTSLNKYIEEMK 12 1 H0Y867;E7EU81;Q14789-4;Q14789-3;Q14789;Q14789-2 H0Y867 GOLGB1 Golgin subfamily B member 1 1 43964000.0 17959000.0 15933000.0 10072000.0 True False 23248279.524814516 15046314.54376735 8238999.347447198 1.0 0.6472012059089088 0.35439178794513104 24.470620618588775 -7.559971774298236 0.22630929553682214 1.1661267378970261 1.0520870066433056e-10 0.9998976156503308 0.0026707500438712833 0.13016367375626203 0.023844619141128908 0.03320334122011151 0.07029184692245556 2.754407712207741e-08 7.559971774298236 -1.1661267377918174 down LTSLNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTSLNVK 7 0 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 0 13896400.0 2614500.0 6358400.0 4923500.0 False True 3427634.8188540116 5409751.504849078 4414063.44954689 1.0 1.5782753387531998 1.2877869676393003 21.7087819818398 -10.101374780902406 4.575386485403332 0.9999675393341614 1.4330311532085327 0.7476606377029598 0.11859138095132206 82561085.80524133 1.6336544894818303 29132.70001337887 0.04059698403879828 7.91817724640345e-11 10.101374780902406 0.4330636138743713 LTSLNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTSLNVK 7 0 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 0 10550200.0 3724000.0 2120500.0 4705700.0 False True 3605783.6584145417 2967226.7082614126 3473136.002026 1.0 0.8229075810849112 0.9632125304913977 21.781881409162786 -10.473404443974887 5.056916210500886 1.0002323755065885 0.8930600557881505 0.4364899912505241 0.05727925573883046 0.00015038854718420883 1.5660473658752336e-05 0.05558051730533323 0.01848680029663521 3.361983332435165e-11 10.473404443974887 -0.10717231971843799 LTSLNVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTSLNVK 7 0 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 0 46696700.0 1990600.0 40411000.0 4295100.0 False True 3019885.7323532845 33199341.317415897 3446171.602390794 1.0 10.993575340198348 1.1411596026533497 21.526062530634096 -6.642897238814951 2.0341723315810003 7.520906472831105 1.1824696787955455 0.1657342171422812 4.272889971428669 0.5261058650188671 4.1641875032500755 1.7085576647322898 4.731163331056319 2.2756358197672912e-07 6.642897238814951 -6.33843679403556 LTSLNVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTSLNVK 7 0 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 0 5771160.0 3724000.0 1270900.0 776260.0 False True 3096671.001172485 1264053.4094461012 938572.3769792859 1.0 0.40819751564421786 0.3030907631530494 21.562286684597062 -13.999999999999998 0.2430874341076329 4.976591239927554 0.257960249521998 0.9995301928049134 0.006649207525042156 13.734457760749974 0.1560339744544586 26.560302980617877 0.050443785623545366 1.0000000000000041e-14 13.999999999999998 -4.718630990405556 LTSLNVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTSLNVK 7 0 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 0 7879900.0 1990600.0 4061200.0 1828100.0 False True 2576870.940592226 3835190.6499182833 1495404.557890016 1.0 1.488313050337269 0.5803179873441145 21.297188852726546 -6.760637936941166 1.6101963450460066 1.2834127500663461 0.5769091329725644 0.6935398015214204 0.20540359387619356 0.28183569159091604 1.440351823008548 0.1006451991706135 0.2417018363043813 1.7352500398934237e-07 6.760637936941166 -0.7065036170937817 LTSLNVK(ub)YNNDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTSLNVKYNNDK 12 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 1 16672500.0 5818200.0 7253500.0 3600800.0 True False 7627716.543528944 6171306.073921544 3228223.757312564 1.0 0.8090633728592127 0.4232228267647495 22.862819801432707 -6.959842182504662 0.437652548508939 1.014138580394158 0.2031627441848406 0.9997643002352483 0.0036831834425058493 0.07975754824439768 0.02134000626173779 0.005072641917326041 0.03198388715909414 1.0968767157988615e-07 6.959842182504662 -0.8109758362093175 down LTSLNVK(ub)YNNDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTSLNVKYNNDK 12 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 1 24651000.0 7008600.0 8463700.0 9178700.0 True False 6786115.829313683 11843299.547612423 6774523.114902358 1.0 1.7452250809591914 0.9982917010698154 22.6941546243289 -10.235826571446513 3.981885032019329 0.9996809024556329 1.3717583910554683 0.24828469459735036 0.3049342757917732 41346984.89613685 35429174.128948145 106687.3636326032 0.10438711000584246 5.809963828130881e-11 10.235826571446513 0.37207748859983536 LTSLNVK(ub)YNNDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTSLNVKYNNDK 12 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 1 58386000.0 11190000.0 13453000.0 33743000.0 True False 16976048.098579925 11052207.041231256 27073681.25991772 1.0 0.6510471092595332 1.5948164792359703 24.01699731319964 -6.8065821274230816 1.4286771490214365 0.8090424674323425 1.6100965132455083 0.850770316637359 0.15051350741428124 0.21149067416519135 0.8513860748122044 0.08285106825613965 0.19198072833864455 1.5610538063821557e-07 6.8065821274230816 0.8010540458131657 LTSLNVK(ub)YNNDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTSLNVKYNNDK 12 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 1 15477700.0 5818200.0 4919300.0 4740200.0 True False 7969345.770942987 4701949.060050299 3620662.3874834273 1.0 0.5900043987542949 0.454323666151457 22.9260298629556 -13.999999999999998 0.1545467809071685 2.9976653479412514 0.3125787962680107 0.9995517795875968 0.0049109700812443036 11.977746120301719 0.12402604196075231 7.177640187740248 0.1283615699920537 1.0000000000000041e-14 13.999999999999998 -2.6850865516732405 LTSLNVK(ub)YNNDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTSLNVKYNNDK 12 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 1 22717300.0 7008600.0 10716000.0 4992700.0 True False 5827961.433624457 10658270.781040551 6036650.486363429 1.0 1.828816285493517 1.0358082418896837 22.474559899763175 -10.382231907521446 4.258365243888461 0.9989881518666801 1.432312263695374 0.2838002753133265 0.3237441781380435 33356871.038654555 81332176.21041094 213885.14982860978 0.11082625054461821 4.147325218020928e-11 10.382231907521446 0.4333241118286939 LTSLNVK(ub)YNNDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTSLNVKYNNDK 12 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 1 60361000.0 11190000.0 11518000.0 37653000.0 True False 14485675.5878765 10877013.174864277 30800540.352405578 1.0 0.7508806274777807 2.1262757242874804 23.788123635292088 -6.860021004985068 1.1856778254904992 0.8648379659540575 2.1928904334416273 0.9536625359307118 0.12880294176525342 0.14677824545106138 0.39209106135989813 0.08472930290637992 0.19778174006706498 1.3803175028757522e-07 6.860021004985068 1.3280524674875698 up LTSMHFYGWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTSMHFYGWK 10 0 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 0 19745500.0 8542600.0 8527800.0 2675100.0 False True 11199431.326656086 7255485.481104039 2398306.3133711554 1.0 0.647844097569048 0.21414536536894316 23.416922142651373 -7.410276950153034 0.39052580547944243 1.0381321107118675 5.4395773757938716e-11 0.9992731958160299 0.008664692192645861 0.11371039966783421 0.039339160618281646 0.015790176531740335 0.06026241234375924 3.887971294902493e-08 7.410276950153034 -1.0381321106574717 down LTSMHFYGWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTSMHFYGWK 10 0 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 0 23478500.0 9392500.0 3101000.0 10985000.0 False True 9094340.228694562 4339245.471501365 8107698.957063907 1.0 0.4771369183891021 0.891510406822301 23.116537547133124 -9.916440564110358 6.718611277105547 1.0000000165663716 0.6843236626056992 0.4362443292749185 0.1691672682664179 4.2088401756058424e-08 6.5390570762803485e-09 0.16379551294276432 0.05459850105993404 1.2121585688314296e-10 9.916440564110358 -0.3156763539606724 LTSMHFYGWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTSMHFYGWK 10 0 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 0 30099400.0 8578500.0 7965900.0 13555000.0 False True 13014211.672356386 6544322.9071392305 10875848.30863244 1.0 0.5028597253447238 0.8356901349417835 23.633584588260327 -9.918251833940493 5.546073236190343 1.0000003311407015 0.6692749301423755 0.5683177171407974 0.1358774457354888 5.563141576624901e-07 1.085192456051536e-07 0.13156290246034016 0.043854257037778885 1.2071136642360166e-10 9.918251833940493 -0.33072540099832604 LTSMHFYGWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTSMHFYGWK 10 0 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 0 22087200.0 8542600.0 5043600.0 8501000.0 False True 11701030.075084673 4820757.075045162 6493238.883590708 1.0 0.41199424701164844 0.5549288260883066 23.480132204174264 -10.192203170495596 8.10386826919091 1.0000001468329656 0.48346153655031227 0.9456900540364573 0.05835279755621755 1.5479937618751986e-07 1.5375775707826106e-08 0.05649987012280374 0.018833284428320298 6.423871271654651e-11 10.192203170495596 -0.5165386102826532 LTSMHFYGWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTSMHFYGWK 10 0 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 0 20423600.0 9392500.0 7261800.0 3769300.0 False True 7810279.908300895 7222679.2420455655 4557443.202725914 1.0 0.9247657352675903 0.5835185494289632 22.8969428225674 -6.942000715615208 0.6406880029901209 1.0037375553369883 0.4858157356766587 0.9984142913906043 0.007216356871007573 0.08686586465088424 0.05054289287017592 0.007135984622883455 0.029121436883720292 1.142876451596506e-07 6.942000715615208 -0.5179218196603296 LTSMHFYGWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTSMHFYGWK 10 0 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 0 45761500.0 8578500.0 21276000.0 15907000.0 False True 11105037.357515516 20091971.896892905 13012089.219603125 1.0 1.8092664842136108 1.171728540903735 23.404710910352776 -10.494605338767894 5.5282754413688675 0.9992117284078348 1.4904975125586715 0.441098485877354 0.2602737754621073 0.0025325097508448165 0.0002315214432298426 0.25238841290567704 0.08400299981827197 3.201803398296163e-11 10.494605338767894 0.4912857841508367 LTSPVINTSLDTK(ub)NIAFER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTSPVINTSLDTKNIAFER 19 1 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 103988000.0 12939000.0 31728000.0 59321000.0 True False 16963154.301454224 26994306.074775353 53183031.96721245 1.0 1.5913494386159757 3.13520887814203 24.015901128448615 -6.954526274223124 0.5067239039007689 0.9708033897477047 3.8231092048844677 0.9995102773168716 0.019919869556463906 0.08171754857208142 0.028822575971712238 0.02307570890370444 0.12739283225460674 1.1103853565037154e-07 6.954526274223124 2.852305815136763 LTSPVINTSLDTK(ub)NIAFER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTSPVINTSLDTKNIAFER 19 1 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 151589000.0 44185000.0 48554000.0 58850000.0 True False 42782371.36064623 67941865.405765 43435419.53784346 1.0 1.5880808670709161 1.0152644221539795 25.350513115284578 -10.313980885452303 3.699214147090468 0.9991346178146499 1.3016726444265148 0.26997219539301287 0.23385133478724518 25359708.650670893 14142295.177259041 169375.31740287098 0.08005353295033674 4.8530985957308795e-11 10.313980885452303 0.3025380266118649 LTSPVINTSLDTK(ub)NIAFER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTSPVINTSLDTKNIAFER 19 1 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 175792000.0 61519000.0 29274000.0 84999000.0 True False 93328820.64133498 24049825.981194034 68198910.39361483 1.0 0.25768916628249405 0.7307379427380205 26.47581932916481 -10.16412016976484 6.065825708469478 1.0000043019546072 0.4942135545137464 0.6038455119284456 0.19312135429400618 1.123552284358992e-05 1.5485037583402508e-06 0.1869905375711821 0.06232964908147346 6.852985773393648e-11 10.16412016976484 -0.5057907474408608 LTSPVINTSLDTK(ub)NIAFER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTSPVINTSLDTKNIAFER 19 1 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 63527000.0 12939000.0 26770000.0 23818000.0 True False 17722897.963327363 25587212.883448143 18192678.94710779 1.0 1.443737527372431 1.0265070071921931 24.079111189971506 -10.567291135624545 7.606138807569459 0.999879759744117 1.2351222672823108 0.29746798886312786 0.17033364659293046 0.00034748561708863304 1.9768214177719737e-05 0.16500845268193223 0.05497494804609996 2.708375424328105e-11 10.567291135624545 0.23524250753819376 LTSPVINTSLDTK(ub)NIAFER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTSPVINTSLDTKNIAFER 19 1 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 170812000.0 44185000.0 80832000.0 45795000.0 True False 36741785.22739159 80396541.97210427 55370522.76784373 1.0 2.188150125927124 1.5070177571710401 25.130918390718854 -10.116875880498439 5.294535620126569 0.9999821165811333 1.8475839415496949 0.6736957805522092 0.27807112512641685 5.870094960395294e-05 9.791476861256716e-06 0.2692468771419688 0.0897470697226716 7.640541157685872e-11 10.116875880498439 0.8476018249685615 LTSPVINTSLDTK(ub)NIAFER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTSPVINTSLDTKNIAFER 19 1 Q8IZ07;H0YIN8;S4R3D2 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 138672000.0 61519000.0 41847000.0 35306000.0 True False 79637558.22078413 39518177.66353056 28880670.270152 1.0 0.4962253809185343 0.36265137851269036 26.24694565125726 -13.999999999999998 0.18633536952695115 3.6672330737974526 0.26320873937103495 0.9994918478045933 0.006186434004413029 12.293322421198994 0.13688119366170437 11.891248154460596 0.09461019041297258 1.0000000000000041e-14 13.999999999999998 -3.404024334426418 LTSTVMLWLQTNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTSTVMLWLQTNK 13 0 P47756-2;B1AK88;B1AK87;P47756;B1AK85 P47756-2 CAPZB F-actin-capping protein subunit beta 0 28554700.0 16924000.0 4489600.0 7141100.0 False True 16386756.883729253 6282320.692954706 5270631.681592085 1.0 0.3833779153209108 0.32163970692855054 23.966027021960343 -13.999999999999998 0.3253005776470357 7.5255478129751845 0.3100950225882871 0.9997050055529969 0.005260292592583408 18.434074962756604 0.18214182192262568 82.09905857669017 0.02013822280630839 1.0000000000000041e-14 13.999999999999998 -7.215452790386897 LTSTVMLWLQTNK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LTSTVMLWLQTNK 13 0 P47756-2;B1AK88;B1AK87;P47756;B1AK85 P47756-2 CAPZB F-actin-capping protein subunit beta 0 498160000.0 141159000.0 166630000.0 190371000.0 False True 214148523.10522285 136893574.61386773 152744088.40742654 1.0 0.6392459430906486 0.7132623946809805 27.67403648668453 -10.07526896821666 5.091178601367194 1.000006342101153 0.6762541688847838 0.9622767230395943 0.030217089831548194 2.1752992023422797e-06 3.950823215044217e-07 0.029258144564617245 0.00975252380685433 8.408742082792616e-11 10.07526896821666 -0.32375217321636907 LTSTVMLWLQTNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTSTVMLWLQTNK 13 0 P47756-2;B1AK88;B1AK87;P47756;B1AK85 P47756-2 CAPZB F-actin-capping protein subunit beta 0 28086200.0 16924000.0 4293300.0 6868900.0 False True 14073055.860323085 4270171.140746674 8305155.231794785 1.0 0.3034288489386157 0.5901458300332588 23.74643229739462 -10.42518746992498 6.037630948446144 1.0001872346354401 0.4467873394863755 0.8323222690966778 0.1170517173788483 0.00029510481672277884 2.8095428133419116e-05 0.1133724216952218 0.03777827933777131 3.756752032752556e-11 10.42518746992498 -0.5533998951490646 LTSTVMLWLQTNK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LTSTVMLWLQTNK 13 0 P47756-2;B1AK88;B1AK87;P47756;B1AK85 P47756-2 CAPZB F-actin-capping protein subunit beta 0 451934000.0 141159000.0 178035000.0 132740000.0 False True 182733108.15988016 168127195.74465713 108582682.02741675 1.0 0.9200696985767693 0.5942146068703303 27.445162808776978 -6.944439042180721 0.6168938511479417 1.003575290951016 0.4935378092438873 0.9986893265271802 0.006354006290193711 0.08579882893749384 0.04581873623988105 0.006417225822697775 0.02754523142336162 1.1364778031405737e-07 6.944439042180721 -0.5100374817071287 LTTDFGNAEK(ub)TDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTTDFGNAEKTDR 13 1 P02786;G3V0E5;H7C3V5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 1 22141100.0 2434300.0 3426800.0 16280000.0 True False 3151249.33722679 3236095.5676007047 13317207.046906311 1.0 1.026924632516887 4.226008678394811 21.58749247897928 -6.908744098741161 0.9042498687248203 0.8969731064007617 4.628513188764309 0.9904388242392624 0.1480847160974285 0.10525422182312313 0.1433173788228027 0.12049110392536322 0.3297836400018036 1.2338316351522306e-07 6.908744098741161 3.7315400823635474 up LTTDFNVIVEALSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTTDFNVIVEALSK 14 0 P05455;E7ERC4;E9PFL9;E9PGX9 P05455 SSB Lupus La protein 0 97276100.0 14087000.0 55674100.0 27515000.0 False True 21371008.897649307 45738621.871271305 22076648.189747076 1.0 2.1402181848467765 1.0330185297042942 24.349151681581183 -6.639331849496283 2.0464663775373935 1.7460288381695852 1.0375918415395224 0.15203926742967833 0.48795077140678556 0.535184966719119 4.2827659143663555 0.19420454830238512 0.540451098953761 2.2943948042095755e-07 6.639331849496283 -0.7084369966300628 LTTDFNVIVEALSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTTDFNVIVEALSK 14 0 P05455;E7ERC4;E9PFL9;E9PGX9 P05455 SSB Lupus La protein 0 44598000.0 14087000.0 15331000.0 15180000.0 False True 18235899.196283873 14477816.372967891 12417395.759953195 1.0 0.7939184252519993 0.680931366547783 24.120278003673633 -13.999999999986793 0.07257728577929748 2.168756127354258 0.2917698823296152 0.9999154068121561 0.0012149190720811174 12.333796422498443 0.07357118572010567 2.403830138756767 0.357035764127675 1.0000000000304107e-14 13.999999999986793 -1.8769862450246428 LTTDK(ub)ANIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTTDKANIK 9 1 Q15833;Q15833-2;Q15833-3;M0R0M7;M0R1A1 Q15833 STXBP2 Syntaxin-binding protein 2 1 3904100.0 1549000.0 1247000.0 1108100.0 True False 1499827.8428797324 1744933.6030190932 817855.3677125643 1.0 1.1634225963352884 0.5452994966023885 20.51636548039356 -6.836417142581421 1.299005096736936 1.0870152905588144 0.5263782758526262 0.9181028258061091 0.0748410395654598 0.1730267595052797 0.5687033430998647 0.04520286801134105 0.1040557467542352 1.4574137327183843e-07 6.836417142581421 -0.5606370147061882 LTTDK(ub)ANIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTTDKANIK 9 1 Q15833;Q15833-2;Q15833-3;M0R0M7;M0R1A1 Q15833 STXBP2 Syntaxin-binding protein 2 1 2794330.0 958730.0 995570.0 840030.0 True False 1313198.3897040605 951582.4254902683 641632.2149609096 1.0 0.7246296012476187 0.4886026513522503 20.32465345525892 -6.972919493678832 0.17491512796974365 1.195232122568022 0.011649402801778303 0.9999971138525786 0.00035498717258158365 0.07536623764255486 0.005485158526761088 0.009511481885672314 0.026910231924485006 1.0643402995256322e-07 6.972919493678832 -1.1835827197662436 down LTTDK(ub)ANIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTTDKANIK 9 1 Q15833;Q15833-2;Q15833-3;M0R0M7;M0R1A1 Q15833 STXBP2 Syntaxin-binding protein 2 1 4337010.0 1549000.0 2264300.0 523710.0 True False 1288062.1323351713 2252101.7664716397 633215.339638551 1.0 1.7484418724341568 0.4916031018554777 20.296770755827836 -6.745391923638799 1.6668188269698312 1.44251931295964 0.4899474488286667 0.6289246154371941 0.3144556697437347 0.3081604041035639 1.6829579807463573 0.14912276488268247 0.36381002419072883 1.7972482787805154e-07 6.745391923638799 -0.9525718641309734 LTTINCEEGDK(ub)LK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTTINCEEGDKLK 13 1 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 27573300.0 3261500.0 6323800.0 17988000.0 True False 4947933.9475887865 5195268.48192509 14432663.915579537 1.0 1.049987436565687 2.916907151238917 22.238394810519186 -6.912640014426932 0.8775490739135087 0.9469101184500481 3.1723251530172125 0.9918805995239882 0.08038419144525266 0.10269843263885894 0.12948389196356683 0.06668295459382657 0.187626535332023 1.222812826591406e-07 6.912640014426932 2.225415034567164 up LTTINCEEGDK(ub)LK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTTINCEEGDKLK 13 1 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 28050300.0 3261500.0 3584800.0 21204000.0 True False 4222076.043776522 3385302.728707541 17345089.571412858 1.0 0.8018099848527331 4.108189760575271 22.009521132611635 -6.892653469710346 1.0065355448972713 0.833480038217802 4.407825002442545 0.9825436432098569 0.2000456247423619 0.11701732024410853 0.20947446661431296 0.15088039856141247 0.37993121143273517 1.28040254968357e-07 6.892653469710346 3.5743449642247427 up LTTINCEEGDKLK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTTINCEEGDKLK 13 1 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 4608300.0 1080300.0 2265700.0 1262300.0 True False 1416283.7616400812 1927666.3916294298 1131689.3048366057 1.0 1.3610735672046106 0.7990554827276207 20.433678917017033 -6.73322231085385 1.7114782214639266 1.2165144340042093 0.7991901334905887 0.5740792153172647 0.15175285354012263 0.3302612553065589 1.8966148677072783 0.07022412280985005 0.1736244974296466 1.8483222397385393e-07 6.73322231085385 -0.4173243005136207 LTTLADLFRPPIDLMHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTTLADLFRPPIDLMHK 17 1 O94888 O94888 UBXN7 UBX domain-containing protein 7 0 3376220.0 992620.0 1261200.0 1122400.0 False True 1301334.4325457544 1073033.8761190951 1006264.8148210471 1.0 0.824564269785713 0.7732561205289304 20.311560340121368 -13.999999999994373 0.172359728387496 1.890325519991413 0.7291149742023845 0.999509371612514 0.002150355940203164 12.115356871011423 0.1315121989726135 3.607399580340383 0.04094896802570147 1.0000000000129578e-14 13.999999999994373 -1.1612105457890287 LTTLADLFRPPIDLMHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTTLADLFRPPIDLMHK 17 1 O94888 O94888 UBXN7 UBX domain-containing protein 7 0 12025000.0 4860700.0 3026200.0 4138100.0 False True 4706399.739112657 4234577.441424516 3054207.4696610053 1.0 0.8997487838172671 0.648947739028399 22.16619243071589 -6.955446897503173 0.49545326008411034 1.0052268860782898 0.5327356653739397 0.9995622962111368 0.003088912770771271 0.08136949690567587 0.0274603313213907 0.0036542413334219774 0.020686355206289694 1.108034039757327e-07 6.955446897503173 -0.4724912207043501 LTTLADLFRPPIDLMHK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LTTLADLFRPPIDLMHK 17 1 O94888 O94888 UBXN7 UBX domain-containing protein 7 0 13975640.0 1594940.0 4949200.0 7431500.0 False True 2184632.4196328456 4730527.979184222 5676332.75654679 1.0 2.165365640769556 2.598301071399814 21.058959125487448 -9.933910850417389 0.24799393568062592 7.588060408339791e-20 2.8480903021274804 0.999110643684522 0.02012855520142068 1.3818181013710333 0.11060648356344967 1.1682477962339508 0.19555717385015847 1.1643650193275055e-10 9.933910850417389 2.8480903021274804 LTTLADLFRPPIDLMHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTTLADLFRPPIDLMHK 17 1 O94888 O94888 UBXN7 UBX domain-containing protein 7 0 8168200.0 4860700.0 1242400.0 2065100.0 False True 4041887.4155206964 1235706.9446029076 2496902.862056429 1.0 0.30572522625391274 0.6177566580574252 21.946597706150165 -10.514284083275776 6.306750848863066 1.0004652668139749 0.46174094215619876 0.7986943846913176 0.12738629860477543 0.000834041388821122 6.423383573862047e-05 0.12344220356397252 0.0411137510859417 3.059961178989687e-11 10.514284083275776 -0.5387243246577761 LTTLELLEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTTLELLEVR 10 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 4410300.0 1234000.0 1631600.0 1544700.0 False True 1617785.9500729984 1388171.6399269882 1384869.261808689 1.0 0.8580687944930852 0.8560274996492585 20.625589306142377 LTTLELLEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTTLELLEVR 10 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 4679770.0 2719200.0 752170.0 1208400.0 False True 2632880.48441483 1052515.4035147312 891883.7887770623 1.0 0.3997581393249826 0.338748300219669 21.328210603258302 -13.999999999999998 0.32311606445407176 7.269794718999445 0.32705276231097663 0.9997003798560885 0.005164787022364509 18.258449399519876 0.1814239658381913 77.5156477233079 0.020068143681528285 1.0000000000000041e-14 13.999999999999998 -6.942741956688469 LTTLELLEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTTLELLEVR 10 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 4490500.0 1234000.0 1640400.0 1616100.0 False True 1690243.1475961034 1567921.7039226135 1234410.464624271 1.0 0.9276308595911436 0.7303153196508286 20.68879936766527 -6.953577537177658 0.5180816244674198 1.0034033049047595 0.6457661540464643 0.9994529528360396 0.0026656208347543217 0.08208019540106556 0.03025725032853717 0.0030291128546230603 0.016295387814126056 1.112813697815144e-07 6.953577537177658 -0.35763715085829517 LTTPTYGDLNHLVSATMSGVTTCLR ddPTM_RPMI8226_Bortezomib_1h_R1 2 LTTPTYGDLNHLVSATMSGVTTCLR 25 0 P04350;M0R2D3;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P04350;P07437;P68371;Q13885;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 272917900.0 160092300.0 93026000.0 19799600.0 False True 209882555.63603842 79146883.41250783 17750927.323174253 1.0 0.37710081799155354 0.08457552496147652 27.645007021282936 -8.884039672987248 0.344322838933827 1.1858913995767597 8.46230605855299e-16 0.9979931492202464 0.017101454898202334 0.39185742235449367 0.11906096630637773 0.18140169385121277 0.08304869695750587 1.30605157431059e-09 8.884039672987248 -1.1858913995767588 LTTPTYGDLNHLVSATMSGVTTCLR ddPTM_RPMI8226_Bortezomib_2h_R1 2 LTTPTYGDLNHLVSATMSGVTTCLR 25 0 P04350;M0R2D3;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P04350;P07437;P68371;Q13885;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 3899018700.0 3085074700.0 231729000.0 582215000.0 False True 2987140692.3330135 324259598.1507706 429715425.4243938 1.0 0.10855183319052766 0.1438551008083847 31.476118043208796 -10.054028375456639 5.054147602540065 1.0000143644632078 0.1262034670006048 0.9987772458399428 0.01441249866772065 20080879.825895846 19973072.7141976 2751.155659061035 0.004933784894166255 8.830222045972122e-11 10.054028375456639 -0.873810897462603 LTTPTYGDLNHLVSATMSGVTTCLR ddPTM_RPMI8226_Bortezomib_8h_R1 2 LTTPTYGDLNHLVSATMSGVTTCLR 25 0 P04350;M0R2D3;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P04350;P07437;P68371;Q13885;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 6864738200.0 2411615200.0 2035553000.0 2417570000.0 False True 3658596571.0872602 1672292663.301822 1939736229.8414292 1.0 0.4570858335454162 0.5301858765108336 31.768643194238237 -10.574208924242344 6.405519550882323 1.0009485274110432 0.49363585502834995 0.9846101300023834 0.029842967573466585 0.0004049259218535989 2.6916394410799526e-05 0.02894377199254387 0.009631776367787002 2.6655760384404443e-11 10.574208924242344 -0.5073126723826933 LTTPTYGDLNHLVSATMSGVTTCLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTTPTYGDLNHLVSATMSGVTTCLR 25 0 P04350;M0R2D3;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P04350;P07437;P68371;Q13885;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 141600400.0 94442300.0 7574100.0 39584000.0 False True 129360170.51719257 7239451.217800687 30235074.45807013 1.0 0.05596352562660336 0.23372784943918845 26.94681824472492 -10.098113135670676 5.689419835498484 1.0000063216618815 0.14484568753333468 0.9686086607702264 0.07257198130235601 5.819396234998631e-06 9.224104959834685e-07 0.0702680381219448 0.023422506248716314 7.977868331286027e-11 10.098113135670676 -0.8551606341285468 LTTPTYGDLNHLVSATMSGVTTCLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LTTPTYGDLNHLVSATMSGVTTCLR 25 0 P04350;M0R2D3;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P04350;P07437;P68371;Q13885;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 4373683700.0 3085074700.0 195537000.0 1093072000.0 False True 2565376305.032466 194483603.36994448 1321628301.4061012 1.0 0.07581094554760971 0.5151791177042837 31.256523318643072 -9.963726526808795 14.145096808209416 0.9999999977304045 0.29549503347656564 0.7741679736605891 0.17937130516719443 0.0 0.0 0.17367551813102466 0.057891839808336024 1.0871099561567656e-10 9.963726526808795 -0.7045049642538388 LTTPTYGDLNHLVSATMSGVTTCLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LTTPTYGDLNHLVSATMSGVTTCLR 25 0 P04350;M0R2D3;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P04350;P07437;P68371;Q13885;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 3987989800.0 2411615200.0 811098600.0 765276000.0 False True 3121883416.442529 765960249.8970274 626003620.3948573 1.0 0.24535197114114526 0.20052113961007723 31.539769516330686 -13.590156823628861 0.40545274991905317 9.999784708057613 0.19817205809217633 0.9998378360565218 0.004670554394186508 19.525753804023573 0.20999842940976546 152.9385325150116 0.011305032063035464 2.5694677810548647e-14 13.590156823628861 -9.801612649965437 LTTPVFGK(ub)GVAYDVPNPVFLEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTTPVFGKGVAYDVPNPVFLEQK 23 1 A0A0C4DFL7;Q16850-2;Q16850 A0A0C4DFL7 CYP51A1 Lanosterol 14-alpha demethylase 1 68954100.0 7222100.0 11828000.0 49904000.0 True False 6992838.388677678 16550982.082205158 36832645.31209075 1.0 2.3668475034405723 5.267195273914471 22.73744673280648 -6.958871039161009 0.4510625864739276 0.9074789945337635 6.841746690800445 0.9997260099842065 0.02945008645692299 0.08010689634438149 0.022640186794601627 0.038827933403947315 0.2398692827900685 1.0993322303165767e-07 6.958871039161009 5.934267696266682 LTTPVFGK(ub)GVAYDVPNPVFLEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTTPVFGKGVAYDVPNPVFLEQK 23 1 A0A0C4DFL7;Q16850-2;Q16850 A0A0C4DFL7 CYP51A1 Lanosterol 14-alpha demethylase 1 55258100.0 7222100.0 11314000.0 36722000.0 True False 6005496.143278145 11253049.236346837 44400400.4166559 1.0 1.8737917680527016 7.393294301979121 22.517852008240755 -6.934755984885044 0.7066615144418272 0.9290209001235007 8.677093712124417 0.9973932129791508 0.1445130543005388 0.09024243270751298 0.0661258405628375 0.1356052420183741 0.48702324858455104 1.1621013751882175e-07 6.934755984885044 7.748072812000917 LTTPVFGK(ub)GVAYDVPNPVFLEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTTPVFGKGVAYDVPNPVFLEQK 23 1 A0A0C4DFL7;Q16850-2;Q16850 A0A0C4DFL7 CYP51A1 Lanosterol 14-alpha demethylase 1 177709500.0 5345500.0 22884000.0 149480000.0 True False 6919855.125557992 21610485.283347305 122276173.79432172 1.0 3.1229678788404858 17.67033725066055 22.72231040316494 -6.933093598591192 0.7209478850517438 0.8021603073105238 20.906569785864388 0.9971120622280136 0.3981536313732297 0.09106307568082532 0.07004252503443564 0.3696577004715792 1.2946248296884921 1.1665581748410975e-07 6.933093598591192 20.104409478553865 LTVAENEAETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTVAENEAETK 11 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 7908800.0 2059100.0 1180700.0 4669000.0 False True 1993734.997594356 1652159.6672691586 3446048.8330023987 1.0 0.8286756611398491 1.7284387529738943 20.927042232288123 -6.857403864763689 1.1987526637009607 0.9076115362698342 1.7699044064006884 0.9504086757682142 0.08687010208637963 0.1495013254112799 0.4097082069565888 0.05657655009884054 0.13170694492779236 1.388660669226895e-07 6.857403864763689 0.8622928701308542 LTVASFLSDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTVASFLSDR 10 0 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 0 4520800.0 1372200.0 1989100.0 1159500.0 False True 1798967.4884037022 1692334.0334510705 1039526.0627093755 1.0 0.9407251906218428 0.5778459418584545 20.778737683238425 -6.935410634865713 0.7009598024584327 1.0045703663015255 0.49192603642455396 0.997498821087303 0.009332687090848894 0.08992420218877116 0.06462023709852865 0.008795125256572776 0.03191433323393798 1.1603509579592802e-07 6.935410634865713 -0.5126443298769716 LTVASFLSDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTVASFLSDR 10 0 Q5VZK9-2;Q5VZK9;A0A0U1RQQ1 Q5VZK9-2 LRRC16A Leucine-rich repeat-containing protein 16A 0 4599100.0 1372200.0 1448400.0 1778500.0 False True 1879539.4223106748 1384404.8987817059 1358454.929357259 1.0 0.7365660343956719 0.7227594767271213 20.841947744761317 LTVEFMHYIIAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTVEFMHYIIAAR 13 0 B5MCF9;O00541-2;O00541;B3KXD6;H7BYY8 B5MCF9 PES1 Pescadillo homolog 0 36862000.0 10525000.0 12706000.0 13631000.0 False True 15967194.480567835 10438515.027568877 10936826.875320464 1.0 0.6537475973172749 0.6849560759487613 23.928607510177006 -9.913448333450626 5.629318859389144 1.0000002528251004 0.6693518370037256 0.9933628408833245 0.012740808051567257 4.0423613227193603e-08 7.804506342894823e-09 0.012336243724142234 0.004112078116413145 1.2205390155165402e-10 9.913448333450626 -0.33064841582137483 LTVGLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTVGLTR 7 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 94724000.0 35147000.0 22669000.0 36908000.0 False True 46078057.36403222 19286873.563069932 33089114.206535317 1.0 0.4185695896573312 0.7181100093938453 25.45757655871843 -10.544161996795895 6.467113021674717 1.0004866157056596 0.5683397995256068 0.7346726638177966 0.12228686428225985 0.0008589040878608489 6.054018770929468e-05 0.11853097839970725 0.03946791573542657 2.8565248282790625e-11 10.544161996795895 -0.4321468161800528 LTVGLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTVGLTR 7 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 45589500.0 18885000.0 6877500.0 19827000.0 False True 18285506.01212638 9623721.615688702 14633713.902749743 1.0 0.5263032704321416 0.8002903443331084 24.124197214931527 -10.216532418120387 5.629142001760848 1.0000130917276562 0.6632968073826129 0.6681708833581209 0.11185475452931161 1.8378583787710948e-05 2.5577924721757705e-06 0.10830710942992919 0.03610096679050522 6.073899222586211e-11 10.216532418120387 -0.3367162843450433 LTVGLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTVGLTR 7 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 93411000.0 35147000.0 28550000.0 29714000.0 False True 48141795.71196136 27288566.597775273 22696165.179039404 1.0 0.5668373228337041 0.47144409225683065 25.52078662024132 -13.999999999999998 0.21263042758874565 3.5326162243628727 0.41666965706341996 0.9994916509603704 0.005185720219441503 12.809565018050654 0.1461363256207627 13.570621146390573 0.055482685783426564 1.0000000000000041e-14 13.999999999999998 -3.115946567299453 LTVGLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTVGLTR 7 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 37916100.0 18885000.0 13558000.0 5473100.0 False True 15703714.24735295 13484960.3629477 6617499.905244794 1.0 0.858711522035034 0.4213971166955138 23.904602490365804 -6.950746204755761 0.5505890388948627 1.0060269131368784 0.25351651184868407 0.9992585585067768 0.006706692977481369 0.08318744825623342 0.03473273535940575 0.007273788171850997 0.03628299031336325 1.1200922575227993e-07 6.950746204755761 -0.7525104012881944 down LTVK(ub)ALCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTVKALCK 8 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;A0A0A0MRS6;Q86UV5-5 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 5490500.0 2305600.0 2001500.0 1183400.0 True False 3022663.9274621634 1702884.0017858925 1060953.119974365 1.0 0.5633719270986366 0.35099936527351355 21.527389152280346 -11.294146367706611 0.1298674497429454 2.0913028209196916 1.1773898847645852e-13 0.9997479177757757 0.004289581873637032 3.8414700815514697 0.08091932362460927 1.4611498761428712 0.2459374198043285 5.07988209438576e-12 11.294146367706611 -2.091302820919574 LTVK(ub)ALCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTVKALCK 8 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;A0A0A0MRS6;Q86UV5-5 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 5026300.0 2305600.0 1687900.0 1032800.0 True False 3158042.626497229 1613322.9968611188 788873.9111836811 1.0 0.5108616911389035 0.24979837338632366 21.590599213803237 -9.156339008604153 0.20605902234012555 1.416263138760666 7.040778073877858e-14 0.9995085289339135 0.006893508406252153 0.5942701671274269 0.07225664296743031 0.30042077147717283 0.13682115593337757 6.97687579216696e-10 9.156339008604153 -1.4162631387605955 down LTVK(ub)SQQALQER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTVKSQQALQER 12 1 Q96R06;J3KTQ0;J3QS12 Q96R06 SPAG5 Sperm-associated antigen 5 1 6004300.0 1568200.0 1524300.0 2911800.0 True False 1518418.3493892797 2132960.9391194903 2149112.2278724327 1.0 1.4047254763335708 1.4153623925427556 20.534137901209007 -11.669039525121532 0.5720877986342386 2.1848577552793796e-06 1.4142510066129363 0.9999430430257507 0.001459162826168385 5.283146280188421 0.2836307670909107 6.527821752033985 0.001923220888563127 2.1426955856158248e-12 11.669039525121532 1.414248821755181 LTVK(ub)SQQALQER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTVKSQQALQER 12 1 Q96R06;J3KTQ0;J3QS12 Q96R06 SPAG5 Sperm-associated antigen 5 1 23474400.0 3116700.0 5395700.0 14962000.0 True False 4728261.761290805 4432795.178203479 12004754.141922425 1.0 0.9375105275460333 2.5389360293464702 22.172878476088062 -6.897820149603936 0.9749592298633327 0.9293780414539716 2.699777667195225 0.98544984238005 0.08933775564549826 0.11302720212425432 0.18661320504830256 0.06899759586158767 0.177632369612139 1.265260209614571e-07 6.897820149603936 1.7703996257412533 up LTVK(ub)SQQALQER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTVKSQQALQER 12 1 Q96R06;J3KTQ0;J3QS12 Q96R06 SPAG5 Sperm-associated antigen 5 1 5777100.0 1568200.0 2560400.0 1648500.0 True False 1304027.7830393892 2546606.61700039 1993193.7281971893 1.0 1.952877576783552 1.5284902316663167 20.314543176643284 -10.179020156488678 4.5180938505666335 0.9998647493033903 1.7406839042376447 0.8024276425906667 0.1732554082670804 121544290.14632542 50.031375290650026 182923.34724579772 0.05930993455347398 6.621857696025115e-11 10.179020156488678 0.7408191549342544 LTVK(ub)SQQALQER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LTVKSQQALQER 12 1 Q96R06;J3KTQ0;J3QS12 Q96R06 SPAG5 Sperm-associated antigen 5 1 18666500.0 3116700.0 6222600.0 9327200.0 True False 4034629.5893417997 5876306.83989499 7629745.30515385 1.0 1.4564674921877123 1.8910646284132737 21.94400479818051 -6.971721312891506 0.21309978544842972 0.7812713967886692 2.5784355910366226 0.9999928765696471 0.0009709885147876042 0.07574801432626221 0.0069955661699068784 0.012699536919130528 0.04471737687006958 1.0672807764433311e-07 6.971721312891506 1.7971641942479533 LTVMYSQINGASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTVMYSQINGASR 13 0 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 0 6329900.0 2435400.0 1126100.0 2768400.0 False True 3192832.9844471514 958090.2695034205 2481952.5243679504 1.0 0.300075285544357 0.7773511913895828 21.606405657524448 -9.800438677978004 5.898947471484623 1.0000000387098789 0.5387132384665155 0.5546637279440988 0.19484707264541531 9.939337526386117e-08 2.0015870176060474e-08 0.18865988371871492 0.06288662228375404 1.5832931106029349e-10 9.800438677978004 -0.4612868002433633 LTVNPGTK(ub)SK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTVNPGTKSK 10 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 9103200.0 2193800.0 4495800.0 2413600.0 True False 2876093.044789424 3825044.1644911417 2163863.8248860305 1.0 1.3299445132419894 0.7523622466965285 21.455678918635783 -6.75177403709034 1.6432662944255807 1.193600886686727 0.7510581657097897 0.6565278138890854 0.1386592737971751 0.2969852197255006 1.5783745078718598 0.06664130825932102 0.1614877175484116 1.7710301835681475e-07 6.75177403709034 -0.44254272097693725 LTVNPGTK(ub)SK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTVNPGTKSK 10 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 8886700.0 2543900.0 3364700.0 2978100.0 True False 2463145.2869604607 4708242.256678707 2198046.268915067 1.0 1.9114756574057847 0.8923737793914187 21.232070296063014 -6.670934589355195 1.9344463917521448 1.581339210369929 0.8965118660435896 0.2830284675676876 0.38709464437202074 0.45897411819069633 3.3122222357661255 0.16106011430779094 0.42972799872900347 2.13336620286266e-07 6.670934589355195 -0.6848273443263395 LTVNPGTK(ub)SK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTVNPGTKSK 10 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 7255900.0 2193800.0 2202600.0 2859500.0 True False 3004907.145215832 2105281.8489758237 2184144.993251103 1.0 0.7006146104473416 0.7268593962141294 21.518888980158675 -10.363367020429408 6.592370772729537 1.0000181904633014 0.7137370033307358 0.9937354796715175 0.010714388922881487 2.8647325780427503e-06 2.766558569622932e-07 0.01037482093615342 0.0034580541552590963 4.3314467493842494e-11 10.363367020429408 -0.2862811871325657 LTVNPGTK(ub)SK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTVNPGTKSK 10 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 9348400.0 2543900.0 4990700.0 1813800.0 True False 2115365.5638782727 4963814.108523615 2193057.193936344 1.0 2.3465514392808062 1.0367272831631205 21.01247557149729 -6.639706907919185 2.0451844883696806 1.8807457374119672 1.0421336873631855 0.1536059772941879 0.57618774541772 0.5341088462447051 4.269292604378955 0.22943541708061777 0.6381578623925905 2.29241421117855e-07 6.639706907919185 -0.8386120500487817 LTVNYEQCASGVHGPEGFHYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTVNYEQCASGVHGPEGFHYK 21 0 P19525-2;P19525;C9JZT2 P19525-2 EIF2AK2 Interferon-induced, double-stranded RNA-activated protein kinase 0 12205400.0 3523800.0 5485600.0 3196000.0 False True 4826644.087114381 5243228.053546626 2441170.623686141 1.0 1.0863092365862221 0.5057697604435548 22.20258901684707 -6.869068638229856 1.1389339468166162 1.0485545281546995 0.47235574229214883 0.9637488115325911 0.048696890657762386 0.1377551038723984 0.33454324132471264 0.033199344662553205 0.07848071962163491 1.351858891278061e-07 6.869068638229856 -0.5761987858625507 LTVSPEPSSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTVSPEPSSKR 11 1 Q969F2-2;Q969F2 Q969F2-2 NKD2 Protein naked cuticle homolog 2 1 3867300.0 1161400.0 1309700.0 1396200.0 True False 1124531.9927182174 1832670.0399952708 1030493.3348978268 1.0 1.6297180087916778 0.9163752935182569 20.100893275419317 -6.67367058104092 1.9239666417139956 1.4006835321806814 0.9191904910395443 0.29537560904518656 0.2672693727288232 0.45286886067505566 3.235153970735227 0.11168554455265092 0.29701767419942965 2.1199685538845544e-07 6.67367058104092 -0.4814930411411371 LTVYLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTVYLGK 7 0 I3L0V6;E9PM35;K7ENA6;P32121-5;P32121-2;P32121;P49407-2;P49407;P32121-3;P32121-4 I3L0V6 ARRB2;ARRB1 Beta-arrestin-2;Beta-arrestin-1 0 12405600.0 3963800.0 3120300.0 5321500.0 False True 5196580.1854938 2654763.402834134 4770882.227432465 1.0 0.5108673989568907 0.9180811335790283 22.30913108248232 -10.049226566392102 7.2553338211327 1.0000000360966255 0.71447426626796 0.3959593373188349 0.166244311012893 9.714365354869604e-08 1.256258044589857e-08 0.16096538357574525 0.053655120662888384 8.928395781667611e-11 10.049226566392102 -0.2855257698286655 LTVYLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTVYLGK 7 0 I3L0V6;E9PM35;K7ENA6;P32121-5;P32121-2;P32121;P49407-2;P49407;P32121-3;P32121-4 I3L0V6 ARRB2;ARRB1 Beta-arrestin-2;Beta-arrestin-1 0 5905500.0 2254100.0 1228300.0 2423100.0 False True 2182544.8293319605 1718766.5954998794 1788417.4185581738 1.0 0.7875057466865248 0.8194184121778509 21.05757985634759 -10.639733673981539 9.791548244458685 1.0000583285586562 0.8034620794532947 0.9806094175347864 0.013028291130978994 1.659397472696094e-05 6.105497348683701e-07 0.01261831064618448 0.004204862881651948 2.292272931439792e-11 10.639733673981539 -0.19659624910536144 LTWFLLQKPGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTWFLLQKPGGR 12 1 H0YMW2;Q12802-4;Q12802;Q12802-2 H0YMW2 AKAP13 A-kinase anchor protein 13 0 5224600.0 1124600.0 1126800.0 2973200.0 False True 1474361.4906418906 958685.8322319976 2665561.7849482675 1.0 0.65023797645082 1.8079431685290193 20.4916588636464 -6.825672370768818 1.347057163957134 0.8124770831601704 1.8364467230077004 0.8969491272351328 0.1556322128197638 0.18621654263964715 0.6623360500892724 0.09074922208558554 0.20892486259282456 1.4939209898885017e-07 6.825672370768818 1.02396963984753 LTWFLLQKPGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTWFLLQKPGGR 12 1 H0YMW2;Q12802-4;Q12802;Q12802-2 H0YMW2 AKAP13 A-kinase anchor protein 13 0 3432050.0 1124600.0 974150.0 1333300.0 False True 1540395.0111722662 931108.8319167357 1018402.0001754487 1.0 0.6044610798941412 0.6611304196580252 20.55486892516929 -10.338589053565109 5.7372484469756095 1.000058915392329 0.6327957497761673 0.9824509713153523 0.02313516108032721 1.743719615256322e-05 2.01018504613442e-06 0.022404103663184367 0.0074668411313269355 4.5857560366474e-11 10.338589053565109 -0.3672631656161617 LTWHAYPEDAENK(ub)EK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTWHAYPEDAENKEK 15 1 P45973 P45973 CBX5 Chromobox protein homolog 5 1 23138300.0 7868600.0 12241400.0 3028300.0 True False 10315810.799630782 10415030.83660347 2714960.5655047917 1.0 1.0096182490062962 0.26318440869446386 23.298353882492254 -6.903981582012984 0.9357487723129378 1.0277355849720056 0.17817593278620478 0.9884453160875887 0.03758238688239825 0.10853372018699059 0.16135015646609124 0.02988151430417644 0.07942118495974236 1.2474364156301151e-07 6.903981582012984 -0.8495596521858008 down LTWHAYPEDAENK(ub)EK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTWHAYPEDAENKEK 15 1 P45973 P45973 CBX5 Chromobox protein homolog 5 1 17069100.0 6849400.0 5842000.0 4377700.0 True False 6631969.546171999 8174741.06562753 3231049.0418150774 1.0 1.232626448103343 0.48719298532968275 22.66100595135574 -6.822857784322712 1.3595034233774228 1.1250337894555806 0.46990498164080974 0.8908237742602241 0.10289386707165711 0.18979266992690563 0.6884841871146883 0.05946358695375106 0.13695808999990491 1.5036342711192436e-07 6.822857784322712 -0.6551288078147709 down LTWHAYPEDAENK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LTWHAYPEDAENKEK 15 1 P45973 P45973 CBX5 Chromobox protein homolog 5 1 45440200.0 18909200.0 16894000.0 9637000.0 True False 28686638.8476915 13879133.706575522 7732242.725952847 1.0 0.48381874852140155 0.26954160670430316 24.773875604718377 -12.064146391657491 0.1469243990906025 2.4325658096219254 1.4264817758616096e-17 0.9996185229462666 0.0059879650795867535 5.579509547986181 0.10073179668003847 2.653777675524867 0.21221374473978277 8.626877046281558e-13 12.064146391657491 -2.4325658096219254 LTWHAYPEDAENK(ub)EK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTWHAYPEDAENKEK 15 1 P45973 P45973 CBX5 Chromobox protein homolog 5 1 22071600.0 6849400.0 12303200.0 2919000.0 True False 5695579.579868632 12236920.219606005 3529349.4040689087 1.0 2.1484942924611454 0.6196646635477812 22.441411226790017 -6.7057280462227595 1.8107445865317422 1.7091523129651462 0.6237406134616305 0.4446251525430569 0.48430794258750476 0.3837415377073808 2.4499694964391994 0.2130783965111726 0.5440787568397537 1.9691189595405365e-07 6.7057280462227595 -1.0854116995035157 LTWILNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTWILNR 7 0 I3L257;I3L2E1 I3L257 CLUAP1 0 59090000.0 14672000.0 15651000.0 28767000.0 False True 19235134.083850104 13315931.807120169 25790466.79254905 1.0 0.6922713275131406 1.3407999486836346 24.197240550588013 -6.777656702906115 1.5448287418613509 0.825226868196986 1.3455803966991688 0.7590700404811805 0.13001308659327238 0.25423149213747465 1.1981971002191647 0.06629524303531269 0.15674933232509372 1.6685656437623788e-07 6.777656702906115 0.5203535285021829 LTWILNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTWILNR 7 0 I3L257;I3L2E1 I3L257 CLUAP1 0 53649800.0 17191000.0 5148800.0 31310000.0 False True 16645281.114877647 7204742.690637293 23108971.72013389 1.0 0.432839952711742 1.3883197021814764 23.98860989994145 -6.745837324745548 1.6648508418600778 0.6648651355100884 1.3896861825716946 0.6311221390155746 0.23829136240509807 0.3073159634103837 1.6744783134323895 0.11312374883548974 0.27588789300562855 1.795406012617834e-07 6.745837324745548 0.7248210470616062 LTWILNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTWILNR 7 0 I3L257;I3L2E1 I3L257 CLUAP1 0 52699000.0 14672000.0 15070000.0 22957000.0 False True 20096634.895891428 14404157.570174195 17535029.414256155 1.0 0.7167447507900436 0.8725356013628446 24.260450612110905 -10.10139602629306 4.903236770499538 1.0000080620818856 0.7946401763926256 0.6985032531595609 0.06360134842042404 5.6055338307846024e-06 1.0272519659619535e-06 0.06158415833867518 0.020527246935125497 7.917789904032727e-11 10.10139602629306 -0.20536788568926 LTWILNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LTWILNR 7 0 I3L257;I3L2E1 I3L257 CLUAP1 0 34246500.0 17191000.0 5313500.0 11742000.0 False True 14295078.190428616 5284875.120852825 14197197.91112614 1.0 0.36969893067051257 0.993152868560872 23.769015175375728 -10.870121063974704 10.971519930045156 1.0119740517368176 0.6814258996156923 0.2582359507211649 0.2545240043267027 0.07087018850019218 0.0008389473914994556 0.23428211935288162 0.08214726916394532 1.3485868979661409e-11 10.870121063974704 -0.3305481521211253 LTWLYQLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTWLYQLSK 9 0 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ56 A0A590UJC4 CUL1 Cullin-1 0 5665500.0 1455800.0 1846900.0 2362800.0 False True 1908567.8979872558 1571349.7191598134 2118320.1215780224 1.0 0.8233135016139236 1.1099003204507252 20.864059081183942 -6.739930667204656 1.6870703914150238 0.8948621125508012 1.1100614461990592 0.6045610994199204 0.07423625264572763 0.31795122673513865 1.7768820400761003 0.03481199142392204 0.08542803098858669 1.819991387326766e-07 6.739930667204656 0.21519933364825805 LTWSFFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTWSFFK 7 0 Q96AA3;B5MDE0;C9JP01 Q96AA3 RFT1 Protein RFT1 homolog 0 7405800.0 2162800.0 2125100.0 3117900.0 False True 2835451.74458499 1808043.3635749193 2795289.617008682 1.0 0.6376561925371623 0.9858357217141825 21.435147173187595 -10.678501486024878 9.48798386242084 1.000167637663443 0.811745957471354 0.2804622787866615 0.1421436975610312 0.0005044940078969195 1.7094518479558043e-05 0.13775075862067426 0.04587668111851815 2.09651760662805e-11 10.678501486024878 -0.18842168019208894 LTWSFFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LTWSFFK 7 0 Q96AA3;B5MDE0;C9JP01 Q96AA3 RFT1 Protein RFT1 homolog 0 3277700.0 1436700.0 410900.0 1430100.0 False True 1391092.7449098194 574974.5128151919 1055513.9079196248 1.0 0.4133257936389179 0.7587660217349855 20.407787177673786 -10.348666318504893 5.913562777787846 1.000058243781712 0.5860459076869822 0.6569097197042771 0.14102538257766867 0.00010830757151166424 1.1929007665357378e-05 0.13656636607977485 0.045515746509653045 4.48057427939058e-11 10.348666318504893 -0.41401233609472987 LTWSFFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTWSFFK 7 0 Q96AA3;B5MDE0;C9JP01 Q96AA3 RFT1 Protein RFT1 homolog 0 5271500.0 2162800.0 1444200.0 1664500.0 False True 2962445.6074723247 1380390.4686692492 1271379.3814535611 1.0 0.465963143825298 0.4291654767421543 21.498357234710486 -13.999999999999998 0.3799266751826546 8.919662951547956 0.42592842573397255 0.9998074011691088 0.003620121393062212 24.026174750566533 0.20100962844855016 155.62493599769766 0.009976019251477763 1.0000000000000041e-14 13.999999999999998 -8.493734525813982 LTYLGCASVNAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTYLGCASVNAPR 13 0 Q9Y3P9-2;Q9Y3P9;Q9Y3P9-3;Q9Y3P9-4 Q9Y3P9-2 RABGAP1 Rab GTPase-activating protein 1 0 4445300.0 1077500.0 2103300.0 1264500.0 False True 1412612.9345248414 1789495.8385991838 1133661.6699404973 1.0 1.2667984235901917 0.8025281676482917 20.42993478096942 -6.7508638761742 1.646615244534408 1.156717691154419 0.8015428001244732 0.6526826631779379 0.11211570488327269 0.2985463577062581 1.592870480500479 0.05378072802237901 0.1304485136559015 1.7747456641317595e-07 6.7508638761742 -0.3551748910299458 LTYTAEVSVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LTYTAEVSVPK 11 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 9455900.0 3606700.0 5849200.0 0.0 False True 4728418.627332478 4976522.160003022 0.0 1.0 1.0524707205991428 0.0 22.172926338519936 -6.987346054305425 1.1414940728195455 1.0400228134606966 8.216916189906476e-19 0.9811354390332614 0.06651037578803752 0.0950271978774522 0.24336232492461934 0.048959373992304614 0.09050580766743221 1.0295654157239152e-07 6.987346054305425 -1.0400228134606966 down LTYTAEVSVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LTYTAEVSVPK 11 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 8129900.0 3606700.0 4523200.0 0.0 False True 4940194.457402642 4323350.06777783 0.0 1.0 0.875137629714049 0.0 22.236136400042827 -7.1459867438488 0.9417790678163523 0.9945919573645022 1.1725379674793806e-20 0.9896905697489762 0.04517349401559912 0.08751597688251966 0.14698939452765505 0.03774974240315769 0.06633008734717717 7.14518135277051e-08 7.1459867438488 -0.9945919573645022 down LVACWTK(ub)AQDGSHPLSLQDLIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVACWTKAQDGSHPLSLQDLIEK 23 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3;H0Y9K1 D6REX3 SEC31A Protein transport protein Sec31A 1 25706100.0 5009400.0 6069700.0 14627000.0 True False 7599626.036195384 4986514.612217441 11735967.03875815 1.0 0.6561526302041369 1.5442821768942658 22.85749699722244 -6.801712418715797 1.4487919311042208 0.8106966373038847 1.5570856728481834 0.8371684257503886 0.1475453968972702 0.21831287701290894 0.9044703142390541 0.0801090819918437 0.1861232168992632 1.5786562788804034e-07 6.801712418715797 0.7463890355442987 LVACWTK(ub)AQDGSHPLSLQDLIEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVACWTKAQDGSHPLSLQDLIEK 23 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3;H0Y9K1 D6REX3 SEC31A Protein transport protein Sec31A 1 20130200.0 5009400.0 4996800.0 10124000.0 True False 6484767.050036515 4718723.687459786 8281535.881012257 1.0 0.7276627905135337 1.2770753085055884 22.62862331931489 -6.77189715583605 1.566987896104719 0.8441784166690722 1.280406551354422 0.7378708562225935 0.11483809044841166 0.26335384232862963 1.2764150267210086 0.0577545738430485 0.1372534377176541 1.6908412880325659e-07 6.77189715583605 0.4362281346853498 LVAGEMGQNEPDQGGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVAGEMGQNEPDQGGQR 17 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 8926730.0 2395700.0 917030.0 5614000.0 False True 2319649.8148398814 1283204.8612482734 4143524.983610084 1.0 0.553189043035295 1.786271771326009 21.145475595139764 -6.808664773279865 1.4200449790312784 0.7561029563515893 1.8072101813199395 0.8563332656302935 0.19320226003505647 0.20862862306176644 0.8294080517681892 0.10698505446575009 0.2476422681986358 1.553585741521567e-07 6.808664773279865 1.0511072249683502 LVAIVDPHIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVAIVDPHIK 10 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 11334500.0 4214500.0 4544900.0 2575100.0 False True 5525250.313276063 3866818.6358814463 2308653.3541034185 1.0 0.6998449693021619 0.4178368803592825 22.39760839446929 -7.075618155929293 0.2184949818932819 1.1388024524668636 7.047742951437661e-14 0.9999913198706303 0.0007003058025573304 0.07418554807399493 0.007714263554210815 0.008869786826878476 0.02913575982182717 8.401983881991424e-08 7.075618155929293 -1.1388024524667932 down LVAIVDPHIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVAIVDPHIK 10 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 12640100.0 4214500.0 3643300.0 4782300.0 False True 5772714.542580055 3482326.9592180243 3652819.23456015 1.0 0.6032390712431858 0.6327732313137314 22.460818455992182 -9.992634615949077 5.189100116990127 1.0000020865786363 0.6180061512784203 0.9955367095240036 0.012057270366646469 3.1570791593283793e-07 6.128356677341003e-08 0.011674470970794423 0.0038914672764711637 1.0171040509855686e-10 9.992634615949077 -0.381995935300216 LVAIVDVIDQNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVAIVDVIDQNR 12 0 P50914;E7EPB3 P50914 RPL14 60S ribosomal protein L14 0 12224400.0 3007400.0 5609800.0 3607200.0 False True 3942730.523703025 4772839.706829135 3233961.5467057065 1.0 1.2105416989915072 0.8202339792850868 21.910763678348953 -6.760161210928482 1.6116050843199161 1.1222654586561924 0.8187827541295511 0.6917644915330463 0.0885569000697171 0.28262613235746664 1.4467491278320406 0.043352717471692025 0.10417755660201973 1.7371558735250764e-07 6.760161210928482 -0.3034827045266413 LVAIVDVIDQNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVAIVDVIDQNR 12 0 P50914;E7EPB3 P50914 RPL14 60S ribosomal protein L14 0 22366900.0 6463300.0 7185400.0 8718200.0 False True 6258126.079331555 10054567.691365983 6434641.87960624 1.0 1.6066419186683971 1.0282058555607654 22.577299293450167 -10.158960021414256 5.134642659419191 0.9999884927381536 1.3174238871021924 0.28648897442428567 0.23614553391727494 4.122005999169529e-05 6.751630986256274e-06 0.22865790405608366 0.07621564334359882 6.934896416401098e-11 10.158960021414256 0.3174353943640388 LVAIVDVIDQNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVAIVDVIDQNR 12 0 P50914;E7EPB3 P50914 RPL14 60S ribosomal protein L14 0 66733000.0 0.0 47797000.0 18936000.0 False True 0.0 39267251.91033451 15193291.300056376 0.0 LVAIVDVIDQNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVAIVDVIDQNR 12 0 P50914;E7EPB3 P50914 RPL14 60S ribosomal protein L14 0 11214800.0 3007400.0 4009800.0 4197600.0 False True 4119317.0519291074 3832633.7773646004 3206213.3322856505 1.0 0.9304051446027319 0.7783361396725111 21.973973739871845 -6.958277734447605 0.4590620769383733 1.0044742987659514 0.6981464192665204 0.9997008905725818 0.0016007644684460352 0.08032217307789302 0.023448553387096303 0.002061997076114557 0.01256373655617208 1.1008350924230884e-07 6.958277734447605 -0.30632787949943097 LVAIVDVIDQNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVAIVDVIDQNR 12 0 P50914;E7EPB3 P50914 RPL14 60S ribosomal protein L14 0 13547400.0 6463300.0 2666900.0 4417200.0 False True 5374520.322738487 2652532.8803617973 5340816.097174787 1.0 0.4935385338742655 0.993728886758302 22.357704568884444 -10.93802573476041 10.37538561675177 1.0583249020117906 0.7436337103162838 0.25940163037601216 0.20420185647142428 0.11518183241171288 0.0006880033855905116 0.08266268274171314 0.0659058657815386 1.1533849102711949e-11 10.93802573476041 -0.31469119169550686 LVAIVDVIDQNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVAIVDVIDQNR 12 0 P50914;E7EPB3 P50914 RPL14 60S ribosomal protein L14 0 22937000.0 0.0 22937000.0 0.0 False True 0.0 21660535.786756568 0.0 0.0 LVALHTFGLFYQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVALHTFGLFYQR 13 0 Q6SJ93;Q6SJ93-2 Q6SJ93 FAM111B Protein FAM111B 0 14137300.0 3697000.0 3581700.0 6858600.0 False True 5608619.286903492 2942517.6510501704 5502994.703768832 1.0 0.5246420733033439 0.9811674535689557 22.419214225523127 -10.73118375016264 10.005390771563352 1.0005049550825686 0.7529047634361499 0.28088845538718366 0.186375706046801 0.002103323704648804 5.651019810239256e-05 0.18080183422967505 0.06015250047140909 1.8570185835738788e-11 10.73118375016264 -0.24760019164641878 LVALHTFGLFYQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVALHTFGLFYQR 13 0 Q6SJ93;Q6SJ93-2 Q6SJ93 FAM111B Protein FAM111B 0 6993190.0 724090.0 2322100.0 3947000.0 False True 991805.6407964856 2219501.943842171 3014799.8910166426 1.0 2.2378396054087415 3.0397083531361635 19.91969790499688 -8.369465731289589 0.18691663898724387 7.724998381602098e-20 4.1177853938268125 0.9997929910011838 0.012071713382253506 0.11169139726408298 0.04426382871092465 0.42404589881918386 0.3998316961580265 4.27104619493807e-09 8.369465731289589 4.1177853938268125 LVALHTFGLFYQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVALHTFGLFYQR 13 0 Q6SJ93;Q6SJ93-2 Q6SJ93 FAM111B Protein FAM111B 0 13727300.0 3697000.0 4623900.0 5406400.0 False True 4785839.378764925 4366575.900265226 4422490.674348541 1.0 0.9123949958788844 0.9240783746256539 22.190340547615577 -9.942541618512958 5.134395155659933 1.0000003041930616 0.9182366852562671 0.9849172143085895 0.0047697194037562285 1.6608299001261925e-08 3.417847691615488e-09 0.004618278157042426 0.0015394203175598115 1.1414539136576779e-10 9.942541618512958 -0.08176361893679451 LVALLNTLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVALLNTLDR 10 0 Q15257;Q15257-2;A6PVN5;F6WIT2;Q15257-3;A6PVN9;Q5T948;A6PVN8;A6PVN6;Q5T949;C9IZ76;A6PVN7 Q15257 PPP2R4 Serine/threonine-protein phosphatase 2A activator 0 10416700.0 1923300.0 4660100.0 3833300.0 False True 2521464.925263695 3964831.2449275246 3436666.8876100522 1.0 1.572431646858178 1.3629643835916716 21.26583072620772 -10.120043267696841 4.645228297543249 0.9999617738416899 1.4676980152328447 0.8692328496687955 0.0855146521637872 10379588.50843023 22612859.63564302 2492.4904677526024 0.029273939225729365 7.585020035656124e-11 10.120043267696841 0.4677362413911548 LVALLNTLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVALLNTLDR 10 0 Q15257;Q15257-2;A6PVN5;F6WIT2;Q15257-3;A6PVN9;Q5T948;A6PVN8;A6PVN6;Q5T949;C9IZ76;A6PVN7 Q15257 PPP2R4 Serine/threonine-protein phosphatase 2A activator 0 7080600.0 3232200.0 1354700.0 2493700.0 False True 3129595.580216828 1895638.774667172 1840525.1606035735 1.0 0.605713654074063 0.5881031952620717 21.57754480727688 LVALLNTLDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVALLNTLDR 10 0 Q15257;Q15257-2;A6PVN5;F6WIT2;Q15257-3;A6PVN9;Q5T948;A6PVN8;A6PVN6;Q5T949;C9IZ76;A6PVN7 Q15257 PPP2R4 Serine/threonine-protein phosphatase 2A activator 0 8419200.0 1923300.0 2958600.0 3537300.0 False True 2634395.9852281907 2827879.269218143 2701862.5929802824 1.0 1.0734450268960583 1.025609896207858 21.329040787730612 -10.048708479826129 4.533946860649075 0.9999975915338423 1.0495274615550134 0.5883663225454346 0.019528610337973817 4.7548025494486794e-07 9.975115531550942e-08 0.018909415061826182 0.00630283188299947 8.939053163415023e-11 10.048708479826129 0.04952987002117115 LVALLNTLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVALLNTLDR 10 0 Q15257;Q15257-2;A6PVN5;F6WIT2;Q15257-3;A6PVN9;Q5T948;A6PVN8;A6PVN6;Q5T949;C9IZ76;A6PVN7 Q15257 PPP2R4 Serine/threonine-protein phosphatase 2A activator 0 6134100.0 3232200.0 1386800.0 1515100.0 False True 2687717.510738371 1379329.033141751 1831900.4049691001 1.0 0.5131971747889611 0.6815821966594398 21.357950082711156 -10.328019100873309 4.7146525777575885 1.0002733558788772 0.5973896857236936 0.8840253413150512 0.06874289732008212 0.00019765073416360324 2.8171379210473764e-05 0.06660461821023085 0.022186674707314006 4.698734424654438e-11 10.328019100873309 -0.40288367015518367 LVALQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVALQLR 7 0 K7ENR6;Q969U7-2;Q969U7;V9GZ55;K7ER45 K7ENR6 PSMG2 Proteasome assembly chaperone 2 0 7198800.0 1560400.0 2819500.0 2818900.0 False True 2045699.5109350947 2398841.590324918 2527227.268798158 1.0 1.1726265648997496 1.235385380545433 20.96416281513016 -13.999999999999998 0.14074586625861502 0.1748329296680717 1.312359197699259 0.9995999738371354 0.001990532684018167 11.934851605247841 0.11759563376982267 2.7036349462770413 0.06884883556534656 1.0000000000000041e-14 13.999999999999998 1.1375262680311873 LVALQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVALQLR 7 0 K7ENR6;Q969U7-2;Q969U7;V9GZ55;K7ER45 K7ENR6 PSMG2 Proteasome assembly chaperone 2 0 9671300.0 1560400.0 2125900.0 5985000.0 False True 2137322.048224441 2031970.7085888078 4571466.264944161 1.0 0.9507087199502048 2.1388757341187126 21.02737287665305 -6.897221750575628 0.9786727479606823 0.9467646132473122 2.2567864747353044 0.9851324258639128 0.06692374757982486 0.1134790148330631 0.18918106022243242 0.05154347752552455 0.13233118610089065 1.2670047685783314e-07 6.897221750575628 1.3100218614879922 up LVALQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVALQLR 7 0 K7ENR6;Q969U7-2;Q969U7;V9GZ55;K7ER45 K7ENR6 PSMG2 Proteasome assembly chaperone 2 0 2808030.0 896130.0 790700.0 1121200.0 False True 745171.8002901989 786440.3421583378 1355637.736156926 1.0 1.0553812447707593 1.8192284458818597 19.507213553505313 -6.921483390898225 0.8136482532623425 0.9840305540890119 1.9467093921483407 0.9945832008578287 0.027512659147207474 0.09730671459909987 0.10114861566871546 0.02389312375003854 0.07261858337688887 1.198164944778403e-07 6.921483390898225 0.9626788380593289 LVAQLYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVAQLYK 7 0 O75390;B4DJV2;A0A0C4DGI3;H0YIC4 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 0 10774200.0 3389200.0 3493300.0 3891700.0 False True 4443274.021059487 2972113.2567767496 3489024.215822407 1.0 0.6689016348507935 0.7852372370656668 22.08319168583149 -10.377418269527242 4.963292947451466 1.0002218179363869 0.7270694359581791 0.880076903773813 0.04749381072448287 0.00011666893214730078 1.4634652989641069e-05 0.046022759931605546 0.015328561498628842 4.1935490823308496e-11 10.377418269527242 -0.2731523819782078 LVAQLYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVAQLYK 7 0 O75390;B4DJV2;A0A0C4DGI3;H0YIC4 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 0 13457300.0 3389200.0 3894100.0 6174000.0 False True 4642278.829686154 3722045.7859333395 4715828.357521346 1.0 0.8017712684838821 1.0158434102158755 22.146401747354382 -11.121140139434404 11.698235683907836 3.3827901099034836 0.9088073393498646 0.1948191476684612 0.0873945858980241 0.037552229991617954 0.0003888699037479505 0.0005850793511264932 0.028206481310978405 7.565887173307581e-12 11.121140139434404 -2.473982770553619 LVAQLYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVAQLYK 7 0 O75390;B4DJV2;A0A0C4DGI3;H0YIC4 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 0 4863260.0 2771100.0 1134700.0 957460.0 False True 2304292.4305448607 1128587.145879684 1157660.4592051469 1.0 0.4897760071245924 0.5023930313095776 21.135892385638034 -10.01092380627785 5.438955052147644 1.0000019246759697 0.49608451921758673 0.9995300451533212 0.005150878557665698 1.3135377623734489e-07 2.3884527560454672e-08 0.004987337596049122 0.0016624389055157358 9.75160707370992e-11 10.01092380627785 -0.503917405458383 LVASAYSIAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVASAYSIAQK 11 0 O95861-4;O95861;O95861-2;A6NF51;F8VZG4;F8W1J0;F8VVW8 O95861-4 BPNT1 3(2),5-bisphosphate nucleotidase 1 0 7942000.0 2027000.0 3429300.0 2485700.0 False True 2657416.6294959243 2917661.807306704 2228503.6085180645 1.0 1.0979316434322701 0.8385977508317095 21.34159300045986 -6.804368756880107 1.4377981515158924 1.0537370326090132 0.8346104189807729 0.8446974983042518 0.042137218533999904 0.21457104764429236 0.8751797907902507 0.02304984355496371 0.05347440710225293 1.5690299844740813e-07 6.804368756880107 -0.21912661362824026 LVASAYSIAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVASAYSIAQK 11 0 O95861-4;O95861;O95861-2;A6NF51;F8VZG4;F8W1J0;F8VVW8 O95861-4 BPNT1 3(2),5-bisphosphate nucleotidase 1 0 5589560.0 1661700.0 743860.0 3184000.0 False True 1608950.2430685915 1040887.177178655 2350014.8820474693 1.0 0.6469355914906816 1.4605889101738279 20.617688280601104 -6.7887680426937065 1.5012246193852292 0.8023567988074536 1.4689548330251434 0.7973206259127299 0.14997848115634912 0.2371905764703448 1.0560403798509816 0.07864149413826044 0.18428772701516377 1.6264171955715352e-07 6.7887680426937065 0.6665980342176898 LVASAYSIAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVASAYSIAQK 11 0 O95861-4;O95861;O95861-2;A6NF51;F8VZG4;F8W1J0;F8VVW8 O95861-4 BPNT1 3(2),5-bisphosphate nucleotidase 1 0 7799900.0 2027000.0 2656100.0 3116800.0 False True 2776436.67761532 2538744.719451871 2380676.032510937 1.0 0.9143895626794548 0.8574573487322242 21.40480306198275 LVASK(ub)TDGK(ub)IVQYECEGDTCQEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVASKTDGKIVQYECEGDTCQEEK 24 2 J3KNN7;Q7Z569;Q7Z569-2 J3KNN7 BRAP BRCA1-associated protein 2 483380100.0 120441100.0 245439000.0 117500000.0 True False 157899448.45327157 208820457.9137287 105342227.13958761 1.0 1.3224901034124044 0.6671475307322708 27.234430890935936 -6.772896468148636 1.5633461551557752 1.1842863227513742 0.6630492293238812 0.7415233185689406 0.1360258778657937 0.26177141576542035 1.2630114018004381 0.0685665197252597 0.16278835007418013 1.6869551322057145e-07 6.772896468148636 -0.521237093427493 LVASK(ub)TDGK(ub)IVQYECEGDTCQEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVASKTDGKIVQYECEGDTCQEEK 24 2 J3KNN7;Q7Z569;Q7Z569-2 J3KNN7 BRAP BRCA1-associated protein 2 1199787100.0 329952000.0 596243100.0 273592000.0 True False 500561306.7223096 489838860.33639675 219516421.2803665 1.0 0.9785791545572634 0.43854053106454954 28.898971534429336 -6.915260656326647 0.859134561740229 1.0140694138971866 0.36028596219037445 0.9927600518342582 0.022103519813057013 0.1010414496458257 0.12065590686955682 0.0185810051861648 0.05336956579065326 1.2154562850348527e-07 6.915260656326647 -0.6537834517068122 down LVASK(ub)TDGK(ub)IVQYECEGDTCQEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVASKTDGKIVQYECEGDTCQEEK 24 2 J3KNN7;Q7Z569;Q7Z569-2 J3KNN7 BRAP BRCA1-associated protein 2 369352400.0 120441100.0 156005000.0 92906300.0 True False 164971429.4683445 149112183.26045313 70963745.40531033 1.0 0.9038667103812995 0.43015778934574356 27.297640952458828 -6.940131226332461 0.6583433189503577 1.005305491659602 0.30191967182614443 0.998181013988391 0.010623099460366036 0.08770686510186253 0.05433779271849858 0.010351083652118922 0.040747676038450795 1.1478067480400085e-07 6.940131226332461 -0.7033858198334576 down LVASK(ub)TDGK(ub)IVQYECEGDTCQEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVASKTDGKIVQYECEGDTCQEEK 24 2 J3KNN7;Q7Z569;Q7Z569-2 J3KNN7 BRAP BRCA1-associated protein 2 113989000.0 46253500.0 4412700.0 63322800.0 True False 38461834.62747894 4388927.909247633 76563304.70845328 1.0 0.1141112469479544 1.9906305939382534 25.19692424500787 -6.7783370264627445 1.5424403741049002 0.4973047210141945 2.004706211381492 0.7614354487982926 0.37437407841022796 0.25316428140348646 1.1895751832827794 0.1911943236985441 0.4517525181675556 1.6659538770802157e-07 6.7783370264627445 1.5074014903672974 LVASK(ub)TDGK(ub)IVQYECEGDTCQEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVASKTDGKIVQYECEGDTCQEEK 24 2 J3KNN7;Q7Z569;Q7Z569-2 J3KNN7 BRAP BRCA1-associated protein 2 865481700.0 329952000.0 458637900.0 76891800.0 True False 427129368.32627594 433114297.68988353 62898281.376493335 1.0 1.0140119828029146 0.1472581518404198 28.670097856521785 -6.903226095173138 0.9406376626579286 1.032916628931432 0.0500709083667054 0.9881043364388842 0.04420815836251599 0.10906980806394619 0.1643258496366476 0.035022946036601985 0.09269197576628779 1.249608310544759e-07 6.903226095173138 -0.9828457205647266 down LVCSPDFESLLDHK(ub)HR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVCSPDFESLLDHKHR 16 1 P05423 P05423 POLR3D DNA-directed RNA polymerase III subunit RPC4 1 7822400.0 2170500.0 3569700.0 2082200.0 True False 2972992.5055570006 3411978.8505806816 1590427.244255094 1.0 1.147658073205077 0.5349583765456287 21.50348439576873 -6.843061234862278 1.2680923649984177 1.0785469184613112 0.5135525039226845 0.9295916756912478 0.06927659615858037 0.16525378547870026 0.5148680565174634 0.04281417580961848 0.0987322077062321 1.4352870457924914e-07 6.843061234862278 -0.5649944145386268 LVDEEPQLTK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVDEEPQLTKR 11 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 5516200.0 1890600.0 2002000.0 1623600.0 True False 2478594.908596441 1703309.40373488 1455605.4466709297 1.0 0.6872076585921079 0.5872704093849681 21.24109107184429 -13.999999999999998 0.15964456103356284 2.5393067204075623 0.48864085572498306 0.9995373061798258 0.003781655518753243 12.007368347571436 0.12625372090882228 5.723352874237599 0.08985229904314784 1.0000000000000041e-14 13.999999999999998 -2.0506658646825793 LVDEEPQLTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVDEEPQLTKR 11 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 9473300.0 3398700.0 2834800.0 3239800.0 True False 3290810.1288543213 3966750.4232867104 2391199.188083352 1.0 1.2054023987909974 0.7266293388114239 21.650011358453547 -6.790103702050182 1.495774616772254 1.1147817820643606 0.7215118026552961 0.8017208795710105 0.08732658162859666 0.2351865120674688 1.039487482628077 0.04595210904679208 0.10758367495731438 1.6214228832430224e-07 6.790103702050182 -0.3932699794090645 LVDEEPQLTK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVDEEPQLTKR 11 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 5272100.0 1890600.0 1914400.0 1467100.0 True False 2589605.9115439146 1829815.4779257812 1120601.1958729473 1.0 0.7065999771505198 0.43273039765531296 21.304301133367183 -7.021162127421539 0.2107162795214351 1.1450717454352586 3.947575963676978e-11 0.999993698516108 0.000581432995553749 0.07226447944382272 0.006853127583935214 0.008290635915214289 0.027516549355416923 9.524405399902755e-08 7.021162127421539 -1.1450717453957828 down LVDEEPQLTK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVDEEPQLTKR 11 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 20835000.0 4964300.0 4719700.0 11151000.0 True False 6426384.210982606 4457044.54605026 9121632.418922123 1.0 0.6935540110460917 1.4194035276218582 22.615575806390755 -6.792002929363169 1.4882631592985027 0.8291718118657878 1.4275608310894503 0.8077614919470999 0.13044789505040638 0.23238113264909954 1.0167559678362577 0.06898298985442586 0.16127767315631739 1.614347667840451e-07 6.792002929363169 0.5983890192236625 LVDQNIFSFYLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVDQNIFSFYLSR 13 0 A0A1B0GW44;A0A1B0GVD5;A0A1B0GWE8;A0A1B0GU92;A0A1B0GU03;P07339;C9JH19;A0A1B0GVP3;A0A1B0GV23;F8WD96;H7C469 A0A1B0GW44 CTSD Cathepsin D;Cathepsin D light chain;Cathepsin D heavy chain 0 13414900.0 7337600.0 2385900.0 3691400.0 False True 7104671.904399167 3338602.31230413 2724511.600373757 1.0 0.4699164658450855 0.3834816916298073 22.76033659629742 -13.999999999999998 0.25522884738591856 4.785851472243097 0.3504162458339957 0.999552759408556 0.005763914006948487 14.211415952043048 0.1598609919379837 27.670128409435055 0.03876217826063138 1.0000000000000041e-14 13.999999999999998 -4.435435226409101 LVDQNIFSFYLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVDQNIFSFYLSR 13 0 A0A1B0GW44;A0A1B0GVD5;A0A1B0GWE8;A0A1B0GU92;A0A1B0GU03;P07339;C9JH19;A0A1B0GVP3;A0A1B0GV23;F8WD96;H7C469 A0A1B0GW44 CTSD Cathepsin D;Cathepsin D light chain;Cathepsin D heavy chain 0 128374000.0 39837000.0 48261000.0 40276000.0 False True 60435641.47481047 39648447.48508593 32315430.946402088 1.0 0.656044124254251 0.5347081648810021 25.84889628352612 -13.999999999999998 0.14519834884904084 2.652111910907465 0.39355338163937326 0.9995830466305018 0.004024026997957052 11.942913712307833 0.1197384944401275 5.57627555826029 0.1266827553053423 1.0000000000000041e-14 13.999999999999998 -2.258558529268092 LVDQNIFSFYLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVDQNIFSFYLSR 13 0 A0A1B0GW44;A0A1B0GVD5;A0A1B0GWE8;A0A1B0GU92;A0A1B0GU03;P07339;C9JH19;A0A1B0GVP3;A0A1B0GV23;F8WD96;H7C469 A0A1B0GW44 CTSD Cathepsin D;Cathepsin D light chain;Cathepsin D heavy chain 0 13222000.0 7337600.0 2734000.0 3150400.0 False True 6101539.510795701 2719271.399343488 3809134.0741961966 1.0 0.44566971901635166 0.6242906511473935 22.540741871731697 -10.526606630150711 7.462407870642965 1.0001364008415834 0.534980185081874 0.9003671213290727 0.07292169018355951 0.00016553107512137343 1.050071506620532e-05 0.0706264446679384 0.023535374304851905 2.974358889769607e-11 10.526606630150711 -0.46515621575970945 LVDQNIFSFYLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVDQNIFSFYLSR 13 0 A0A1B0GW44;A0A1B0GVD5;A0A1B0GWE8;A0A1B0GU92;A0A1B0GU03;P07339;C9JH19;A0A1B0GVP3;A0A1B0GV23;F8WD96;H7C469 A0A1B0GW44 CTSD Cathepsin D;Cathepsin D light chain;Cathepsin D heavy chain 0 98466000.0 39837000.0 35875000.0 22754000.0 False True 51569781.804668166 33878524.7133405 18613005.475755915 1.0 0.6569452793432949 0.36092852877013804 25.62002260561857 -7.455190646134543 0.23015328503238988 1.1524569488218235 3.3959487416760605e-14 0.9999218686143919 0.002308218872956645 0.12410345177659728 0.020343358026630495 0.02577087649657759 0.06139154420848298 3.505979350545688e-08 7.455190646134543 -1.1524569488217895 down LVDQSGPPHEPK(ub)FVYQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVDQSGPPHEPKFVYQAK 18 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 8257900.0 2689700.0 1673500.0 3894700.0 True False 2604316.945767344 2341737.2771872114 2874561.2315044864 1.0 0.8991752255780967 1.1037678175754897 21.31247360471773 -6.772688652677458 1.5639876115742923 0.9423687227763521 1.1050421631745662 0.7407977533786735 0.0425254222213918 0.2621049540304294 1.265607634573755 0.021426638105457023 0.05088318220991647 1.687762555005335e-07 6.772688652677458 0.16267344039821408 LVDSVK(ub)ENAGTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVDSVKENAGTVR 13 1 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 1 20119000.0 2114000.0 4534000.0 13471000.0 True False 2736614.6731698816 4281678.914293683 11019416.22413238 1.0 1.5645896209911494 4.026659775001624 21.383960880811017 -6.942895671265486 0.6320497430762004 0.9731379303451898 4.751270875679607 0.9985191218934594 0.0505686030804776 0.08647007529338051 0.04877769581104224 0.05038068976299563 0.2093525174618575 1.1405237378695336e-07 6.942895671265486 3.7781329453344172 LVEALCAEHQINLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVEALCAEHQINLIK 15 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 152635000.0 54623000.0 49883000.0 48129000.0 False True 71611281.9698844 42440650.842411056 43149072.76596777 1.0 0.5926531361393469 0.6025457383113711 26.093683558402237 -10.030608303123138 5.028201122380812 1.0000053747975783 0.5975994372224427 0.9995469258640408 0.004038637935090359 2.4334062526302226e-07 4.6923176433855344e-08 0.003910446555789579 0.0013034647872143294 9.319480348094923e-11 10.030608303123138 -0.40240593757513565 LVEALCAEHQINLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVEALCAEHQINLIK 15 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 59604900.0 31228000.0 9844900.0 18532000.0 False True 30236684.233343013 13776019.910475262 13677913.251917 1.0 0.45560617044391327 0.45236154686676605 24.849796605940128 LVEALCAEHQINLIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVEALCAEHQINLIK 15 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 238184000.0 17845000.0 189960000.0 30379000.0 False True 27072169.644250173 156060153.83574578 24374577.334411286 1.0 5.764597218712066 0.9003555184055289 24.69030717827227 -6.65089697281766 2.005167198259371 4.0895495945767175 0.9207437104169749 0.19773615143741197 2.03313414196752 0.5063554128069768 3.9033354606128046 0.8219952386329987 2.2522911410310273 2.234102153464727e-07 6.65089697281766 -3.1688058841597426 LVEALCAEHQINLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVEALCAEHQINLIK 15 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 129101000.0 54623000.0 30818000.0 43660000.0 False True 74818599.23107123 29456358.85850226 33348407.205925237 1.0 0.39370369348306916 0.4457234905311627 26.15689361992513 -10.389769615207019 9.154038481648337 1.0000015051161661 0.4197135935885629 0.9940089341397434 0.021236993215161343 6.523493493305126e-07 4.348079245215924e-08 0.02056268355556786 0.006854210087153334 4.075964424647338e-11 10.389769615207019 -0.5802879115276032 LVEALCAEHQINLIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVEALCAEHQINLIK 15 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 50240700.0 31228000.0 3638700.0 15374000.0 False True 25967465.63496628 3619097.600874599 18588632.318655517 1.0 0.1393704588560746 0.7158431469579051 24.630201881374404 -10.18324233919461 6.956521980528505 1.0000011909728383 0.42760680301679715 0.5679466643796116 0.23534398941668017 4.347126328022398e-06 5.105640081433873e-07 0.22787131320222123 0.07595694597006801 6.557792350360553e-11 10.18324233919461 -0.5723943879560411 LVEALCAEHQINLIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVEALCAEHQINLIK 15 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 86917000.0 17845000.0 42365000.0 26707000.0 False True 23100704.277538583 40007350.50817196 21846600.036961097 1.0 1.7318671338982574 0.9457114282962843 24.46143350036472 -6.662253169926163 1.9647832336674493 1.4702210135123066 0.9489709410224904 0.24522233231191326 0.31144628434772714 0.4791596378194103 3.55814041165884 0.12795805072242447 0.3453694382638498 2.1764406566294694e-07 6.662253169926163 -0.5212500724898163 LVEDMENK(ub)IR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVEDMENKIR 10 1 P47756-2;B1AK88;B1AK87;P47756 P47756-2 CAPZB F-actin-capping protein subunit beta 1 4519200.0 1103000.0 1121200.0 2295000.0 True False 1067985.868751676 1568901.0069807603 1693870.6514757979 1.0 1.4690278709535576 1.586042194973696 20.026461127195375 -11.807832470805991 0.2350357751074946 3.5076986065420993e-15 1.646711947835669 0.9993487169292874 0.00646246779357243 4.704428997054103 0.13761995039903469 2.381285897312946 0.05866347274627486 1.5565659614784426e-12 11.807832470805991 1.6467119478356655 LVEDMENK(ub)IR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVEDMENKIR 10 1 P47756-2;B1AK88;B1AK87;P47756 P47756-2 CAPZB F-actin-capping protein subunit beta 1 3146430.0 615130.0 1374500.0 1156800.0 True False 842560.1842632015 1313770.0451363274 883587.6650438459 1.0 1.5592595872367117 1.0486938281050178 19.6844202164428 -10.461065871980495 3.7256454636633016 0.9970223052258618 1.3039767076698372 0.3209401394627657 0.20843759846311846 150277438.85340554 14254.401007325961 3848200.131450265 0.07135369412538371 3.458869111593495e-11 10.461065871980495 0.3069544024439754 LVEDMENK(ub)IR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVEDMENKIR 10 1 P47756-2;B1AK88;B1AK87;P47756 P47756-2 CAPZB F-actin-capping protein subunit beta 1 13705400.0 2045800.0 2842900.0 8816700.0 True False 2648328.428746896 2684690.1158900545 7212151.0669815065 1.0 1.013730052039038 2.7232842379727296 21.33665061637225 -6.908659985765218 0.9048131398339695 0.9447995374578412 2.9379971343783295 0.9904059533946695 0.07925532326222429 0.10531077499445017 0.14362373389707625 0.06446051683299668 0.17633040260280416 1.2340706234554532e-07 6.908659985765218 1.9931975969204885 up LVEEKPTKENWK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVEEKPTKENWK 12 2 A0A494C1B8;A0A494C0U1;Q5VZU9;P29144;A0A494C0A3 A0A494C1B8 TPP2 Tripeptidyl-peptidase 2 1 3830360.0 1525500.0 1365300.0 939560.0 True False 1999945.2729630142 1161602.5618977172 842343.3440959221 1.0 0.5808171741503444 0.42118319710216384 20.931529091571615 -13.999999999999998 0.13381453584333208 2.9941996755225135 0.2080910528940811 0.9996287024616339 0.004703416555962876 11.932687973676694 0.11411706545417731 6.238987782290976 0.18981986678548637 1.0000000000000041e-14 13.999999999999998 -2.7861086226284324 LVEEKPTKENWK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVEEKPTKENWK 12 2 A0A494C1B8;A0A494C0U1;Q5VZU9;P29144;A0A494C0A3 A0A494C1B8 TPP2 Tripeptidyl-peptidase 2 1 4944400.0 1544800.0 1326700.0 2072900.0 True False 1495761.1695807674 1856458.2286491033 1529945.3043329795 1.0 1.2411461578250707 1.0228540060053792 20.51244840566728 -10.600824620988233 2.842713525900864 0.9903225467438649 1.1320000820415135 0.32774945877913886 0.0891174001441271 16687784.411358396 16050654.458696665 1198441.5657662167 0.03381471927679275 2.5071214872161463e-11 10.600824620988233 0.1416775352976486 LVEEKPTKENWK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVEEKPTKENWK 12 2 A0A494C1B8;A0A494C0U1;Q5VZU9;P29144;A0A494C0A3 A0A494C1B8 TPP2 Tripeptidyl-peptidase 2 1 10791800.0 3458600.0 2751200.0 4582000.0 True False 5246949.0575289205 2260226.864776289 3676365.6916380567 1.0 0.43076973684984765 0.7006673118662717 22.323047352289997 -10.445260572399496 6.1522495708898886 1.000167832436486 0.5657185243580686 0.775386900990714 0.11018522360079754 0.0002537466036200819 2.2880140540087724e-05 0.10672700635503737 0.03556212800033572 3.587066496202913e-11 10.445260572399496 -0.4344493080784174 LVEEKPTKENWK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVEEKPTKENWK 12 2 A0A494C1B8;A0A494C0U1;Q5VZU9;P29144;A0A494C0A3 A0A494C1B8 TPP2 Tripeptidyl-peptidase 2 1 4751200.0 1525500.0 1239600.0 1986100.0 True False 2089518.5750874034 1184830.3731909709 1517024.085013467 1.0 0.5670350995283255 0.7260160800197771 20.994739153094507 -10.030463936691818 4.846668827465677 1.0000070686709155 0.6465255897680166 0.8682684840097499 0.06490371352271541 4.957492600253923e-06 9.91598736838588e-07 0.0628440066861625 0.020947583462078607 9.322578807366322e-11 10.030463936691818 -0.35348147890289894 LVEEKPTKENWK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVEEKPTKENWK 12 2 A0A494C1B8;A0A494C0U1;Q5VZU9;P29144;A0A494C0A3 A0A494C1B8 TPP2 Tripeptidyl-peptidase 2 1 10768400.0 3458600.0 3206100.0 4103700.0 True False 4477225.879198369 3027677.7166115986 3356868.707517782 1.0 0.6762396623048408 0.7497653230126547 22.094173674382446 -9.953150337806095 5.486486990750539 1.0000005180254203 0.7130024926581082 0.9530847101276894 0.03001672529144462 1.9021315279459145e-07 3.623172079666639e-08 0.02906362169095691 0.009687856429793971 1.1139088699213047e-10 9.953150337806095 -0.2869980253673121 LVEGILHAPDAGWGNLVYVVNYPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVEGILHAPDAGWGNLVYVVNYPK 24 0 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A1W2PNU8;A0A0A0MSV7;K7EJ99 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 0 35919900.0 18646000.0 2765900.0 14508000.0 False True 18054092.936304364 3870338.293977958 10707919.56932938 1.0 0.214374563575843 0.5931020521001743 24.105822603237037 -10.692883089629346 6.609287984137112 1.0055668920886212 0.40373830785597936 0.7677068024732248 0.15461484974173056 0.012710008294045748 0.0005906014793858653 0.15002448711385832 0.04990172817717371 2.0282286372302944e-11 10.692883089629346 -0.6018285842326418 LVEGILHAPDAGWGNLVYVVNYPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVEGILHAPDAGWGNLVYVVNYPK 24 0 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A1W2PNU8;A0A0A0MSV7;K7EJ99 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 0 47608000.0 13681000.0 21312000.0 12615000.0 False True 20755077.21507346 17508707.088583995 10121639.720649084 1.0 0.8435866996374374 0.4876705403581058 24.3069609634186 -6.957445029662267 0.4700601021953089 1.0093952375915594 0.30726970905796464 0.9996633861246705 0.003933204943520992 0.08062675508919259 0.024601702698492725 0.004921676053392633 0.029375587094222225 1.1029478294012383e-07 6.957445029662267 -0.7021255285335948 down LVEGILHAPDAGWGNLVYVVNYPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVEGILHAPDAGWGNLVYVVNYPK 24 0 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A1W2PNU8;A0A0A0MSV7;K7EJ99 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 0 31365700.0 18646000.0 5471400.0 7248300.0 False True 15504975.157857701 5441924.482212137 8763886.01764737 1.0 0.35097924548781023 0.5652305746008215 23.886227878671313 -10.231527885276277 5.0172202325183965 1.0000755649033104 0.4581049100439548 0.8950623850435897 0.08746773884140609 246711941.78253052 29.38069344382889 215372.8333552946 0.02994253351066723 5.867756925855757e-11 10.231527885276277 -0.5419706548593556 LVEIDNGK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVEIDNGKQR 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 97020400.0 37479500.0 41985900.0 17555000.0 True False 49135987.45199434 35721767.379756406 15738576.999450726 1.0 0.7269980564582411 0.32030651698670454 25.550276713212615 -6.9764944610731705 0.3536601430212578 1.0379674185340908 2.7314685172764598e-14 0.9999212039264781 0.002478968299031118 0.07634391444594398 0.014409669636461063 0.005506247291337063 0.034241019286046157 1.0556149662853823e-07 6.9764944610731705 -1.0379674185340635 down LVEIDNGK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVEIDNGKQR 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 115611300.0 52030900.0 42536400.0 21044000.0 True False 50379207.5597747 59521406.344395675 15531945.093532328 1.0 1.1814676972394573 0.3083007027274843 25.58632509357677 -6.8524971171016835 1.2230854137684144 1.0970806204897565 0.27169812103442903 0.9438444319949492 0.08915087618270612 0.15473517339648596 0.44419622723084334 0.05699947508204426 0.13211946531527965 1.4044390063798193e-07 6.8524971171016835 -0.8253824994553275 down LVEIDNGK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVEIDNGKQR 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 205246400.0 99192200.0 81550500.0 24503700.0 True False 150481819.3211762 66997176.11803528 19660532.95464676 1.0 0.4452177440454912 0.1306505532916565 27.165013955322593 -8.589721973457864 0.31997555254839133 1.1682565984866264 2.071008756909632e-26 0.9984315814499436 0.014233345259164773 0.21566735373007478 0.09426828417728869 0.12970345464628238 0.09257052227401838 2.572041824978674e-09 8.589721973457864 -1.1682565984866264 LVEIDNGK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVEIDNGKQR 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 90040900.0 37479500.0 31056100.0 21505300.0 True False 51336683.995403744 29683938.813210838 16426191.055556173 1.0 0.5782208063120806 0.31996984957241953 25.613486774735506 -8.668990316593778 0.18835465424155473 1.3632932561562903 4.187782833006122e-12 0.9997300170091881 0.004605387927174572 0.2422116501052699 0.052312736982601686 0.18647374808026707 0.13642269942734345 2.1429383813990675e-09 8.668990316593778 -1.3632932561521025 down LVEIDNGK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVEIDNGKQR 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 132589100.0 52030900.0 66059700.0 14498500.0 True False 43265998.709695294 65703823.284276254 17530069.31651013 1.0 1.5186017945669879 0.4051696445084461 25.366730369011048 -6.780045233418774 1.5356365581450966 1.2936259503666663 0.39632747557685877 0.7675747533864709 0.21931522612855403 0.2505010379573763 1.1667937021733004 0.11248436976769562 0.26541226116399547 1.6594140641630302e-07 6.780045233418774 -0.8972984747898075 down LVEIDNGK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVEIDNGKQR 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;H0YAB0;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 206757900.0 99192200.0 95959700.0 11606000.0 True False 128406258.27057777 90619458.3396443 9493827.08761639 1.0 0.7057246240186432 0.07393585963396729 26.936140277415042 -7.357821521386742 0.6355331648417711 0.9983435898640162 1.4939980461958727e-22 0.9947615440876088 0.027962432278342334 0.10569911133630683 0.08681762391619605 0.025830751003353237 0.06549377169065149 4.387109543495955e-08 7.357821521386742 -0.9983435898640162 down LVELLMHNDYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVELLMHNDYK 11 0 O60684;Q5TFJ7;O15131;P52294;C9JYI4 O60684;P52294 KPNA6;KPNA5;KPNA1 Importin subunit alpha-7;Importin subunit alpha-6;Importin subunit alpha-5;Importin subunit alpha-5, N-terminally processed 0 6584600.0 1900700.0 2645500.0 2038400.0 False True 2491836.1064049816 2250801.712078231 1827485.9217134912 1.0 0.9032703660938217 0.7333892935478968 21.248777751549465 -6.962505041516615 0.39856671398172266 1.0094874982460262 0.6209835609850445 0.9998521075325257 0.0013401481064095621 0.0788181995026669 0.01791226243424537 0.002186353820974834 0.014240923536230425 1.0901718370290044e-07 6.962505041516615 -0.38850393726098176 LVELLMHNDYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVELLMHNDYK 11 0 O60684;Q5TFJ7;O15131;P52294;C9JYI4 O60684;P52294 KPNA6;KPNA5;KPNA1 Importin subunit alpha-7;Importin subunit alpha-6;Importin subunit alpha-5;Importin subunit alpha-5, N-terminally processed 0 8721100.0 1900700.0 2890900.0 3929500.0 False True 2603440.154486153 2763170.479072101 3001433.030592832 1.0 1.0613535610990352 1.1528719127347222 21.311987813072356 -6.965350134644928 0.3519978085560128 0.9913566851091825 1.2259664104564354 0.9999201666568425 0.0005612047832878517 0.07784240369168544 0.014442556665811051 0.0012499944662306963 0.007855936695331042 1.0830533882578984e-07 6.965350134644928 0.23460972534725288 LVEWCEAK(ub)DHAGVMGESNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVEWCEAKDHAGVMGESNR 19 1 P52306-6;P52306-2;P52306-3;P52306-4;P52306;P52306-5 P52306-6 RAP1GDS1 Rap1 GTPase-GDP dissociation stimulator 1 1 9963600.0 3947000.0 4296700.0 1719900.0 True False 5174555.222802366 3655649.108405417 1541941.24644576 1.0 0.7064663436765178 0.2979852721739234 22.30300343088606 -7.09100731529106 0.35483924239551456 1.0407755443465185 1.4338468012061838e-14 0.9999048758167988 0.002807676996056099 0.07550490971956585 0.015883646851276967 0.006398016502848776 0.03471617141199314 8.109473980758304e-08 7.09100731529106 -1.040775544346504 down LVEYDIDEVVYDEDSPYQNIK(ub)ILHSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVEYDIDEVVYDEDSPYQNIKILHSK 26 1 P52788;P52788-2;H7C2R7 P52788 SMS Spermine synthase 1 58691000.0 19357000.0 21425000.0 17909000.0 True False 29365984.18625667 17601541.35571094 14369278.300206447 1.0 0.599385372002907 0.48931710270862616 24.807642654059077 -13.999999999999998 0.1812758735100153 3.0868130220677465 0.40302624430175454 0.9994966547026086 0.004923318987457068 12.221530737324537 0.1349815537963899 8.98570492623555 0.08129855843639013 1.0000000000000041e-14 13.999999999999998 -2.683786777765992 LVEYDIDEVVYDEDSPYQNIK(ub)ILHSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVEYDIDEVVYDEDSPYQNIKILHSK 26 1 P52788;P52788-2;H7C2R7 P52788 SMS Spermine synthase 1 13156000.0 5819600.0 4454200.0 2882200.0 True False 4839255.251993392 4430204.340510521 3484854.6942128907 1.0 0.9154723422959816 0.7201221082060933 22.20635360712805 -6.957122833249798 0.47424936453034083 1.0049523234991349 0.6225762029344674 0.9996481444287251 0.0021985478882054162 0.08074541971597271 0.025054067226778543 0.0027230748999991644 0.016118955200473406 1.1037663930750156e-07 6.957122833249798 -0.3823761205646675 LVEYDIDEVVYDEDSPYQNIK(ub)ILHSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVEYDIDEVVYDEDSPYQNIKILHSK 26 1 P52788;P52788-2;H7C2R7 P52788 SMS Spermine synthase 1 55288000.0 19357000.0 17396000.0 18535000.0 True False 25058018.083514377 16427897.307686998 15161820.185160216 1.0 0.6555944389909624 0.6050686105592344 24.578768976151526 -13.999999999999998 0.2702962091917885 3.6624799942577058 0.5883453469995619 0.9995839645926259 0.0035792500049539188 14.897673902100165 0.16458335152729134 21.799780124568354 0.020953589450964052 1.0000000000000041e-14 13.999999999999998 -3.074134647258144 LVFAAYGNVFSAFAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVFAAYGNVFSAFAR 15 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 51014000.0 14263000.0 17035000.0 19716000.0 False True 21638013.764972784 13994971.154937502 15819123.958170207 1.0 0.6467770705272543 0.7310802243678166 24.367064739026045 -10.473599257064523 7.662236391833915 1.000028804018974 0.6889286474475371 0.9477914454498582 0.03441661843612161 1.693632970692861e-05 1.1634913823402858e-06 0.03332682471379297 0.011107915836322842 3.360475573274068e-11 10.473599257064523 -0.31110015657143686 LVFAAYGNVFSAFAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVFAAYGNVFSAFAR 15 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 34947200.0 14263000.0 10707000.0 9977200.0 False True 18463734.665762514 10111146.037790576 8161451.974717054 1.0 0.5476219313603858 0.44202606474035366 24.138191061118494 -13.999999999999998 0.2043961628516689 3.5578846905296344 0.37634317772126774 0.9994876434686282 0.0054780255266322605 12.621258177920454 0.14333239425817082 12.931154643593333 0.0650988043765046 1.0000000000000041e-14 13.999999999999998 -3.1815415128083666 LVFFEVSPVSFHQVSEVLSEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVFFEVSPVSFHQVSEVLSEEK 22 0 Q8N543;Q8N543-2;H3BUA6 Q8N543 OGFOD1 Prolyl 3-hydroxylase OGFOD1 0 42300700.0 9458700.0 17884000.0 14958000.0 False True 14349539.423595907 14692460.471670242 12001544.743675701 1.0 1.0238977041667585 0.836371425548388 23.77450109574959 -6.874911794693768 1.1078544533857535 1.0140117971581042 0.824316562338757 0.9693409057511798 0.014592791843824237 0.13222913998283828 0.3003764628297218 0.010189457059296154 0.024350673549954363 1.3337922981694518e-07 6.874911794693768 -0.18969523481934714 LVFGFLNGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVFGFLNGR 9 0 P00491;G3V5M2;G3V2H3 P00491 PNP Purine nucleoside phosphorylase 0 77835000.0 29407000.0 15691000.0 32737000.0 False True 28473490.881577972 21956498.127484016 24162197.611051545 1.0 0.7711206967491866 0.8485857147457888 24.763116044148113 -10.551032565026539 8.838395030397406 1.0000204614997095 0.8098532057474876 0.8893010912904248 0.031624961167865236 1.2752311252201992e-05 6.478041150861119e-07 0.0306240265672377 0.010206912327299854 2.811689991449908e-11 10.551032565026539 -0.19016725575222182 LVFGFLNGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVFGFLNGR 9 0 P00491;G3V5M2;G3V2H3 P00491 PNP Purine nucleoside phosphorylase 0 38500800.0 11841000.0 9223800.0 17436000.0 False True 17963662.69305497 7577740.82412166 13989766.957529718 1.0 0.421837180624157 0.7787814320816867 24.098578201950144 -10.642348377636768 5.152701372208259 1.0057392088456742 0.6003093063529608 0.6257214066628306 0.1457218804484438 0.009700438832246534 0.000673311618671801 0.14245847653645463 0.047031534679570317 2.2785135854074376e-11 10.642348377636768 -0.4054299024927135 LVFGFLNGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVFGFLNGR 9 0 P00491;G3V5M2;G3V2H3 P00491 PNP Purine nucleoside phosphorylase 0 60678000.0 29407000.0 13471000.0 17800000.0 False True 24453223.450987976 13398429.04921587 21521897.702098873 1.0 0.54792077110286 0.8801251804383005 24.54352131958239 -10.251961194101163 5.715754776556935 1.0000151608923789 0.7140229757705763 0.4970010548748687 0.13562188219576662 2.620304763307051e-05 3.429445895084621e-06 0.13132227888843281 0.04377177426045674 5.5980762024565556e-11 10.251961194101163 -0.2859921851218026 LVFGFLNGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVFGFLNGR 9 0 P00491;G3V5M2;G3V2H3 P00491 PNP Purine nucleoside phosphorylase 0 66690000.0 11841000.0 31248000.0 23601000.0 False True 15328407.921004992 29509021.33080041 19305860.166709844 1.0 1.9251197830117297 1.259482411102488 23.869704524042593 -10.197840166034558 5.7959803076802165 0.999986718722214 1.5923010970571214 0.5135522377317724 0.27174531915085065 4.663799660536664e-05 6.455052777517388e-06 0.2631221662957629 0.08770542462341561 6.34103038087865e-11 10.197840166034558 0.5923143783349074 LVFHTQLAHGSPTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVFHTQLAHGSPTGR 15 0 O14908 O14908 GIPC1 PDZ domain-containing protein GIPC1 0 17598100.0 5994000.0 5621100.0 5983000.0 False True 7858192.045978574 4782453.790876185 5363936.552988525 1.0 0.6085946694728087 0.6825916854161787 22.905765995506535 -10.79911557860991 7.157692696264064 1.0129310299609493 0.6455931774444936 0.9683398230925714 0.030209155258307994 0.00618065577233615 0.00017346317536619057 0.029000945874506506 0.009749962934868421 1.5881240455614005e-11 10.79911557860991 -0.3673378525164557 LVFHTQLAHGSPTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVFHTQLAHGSPTGR 15 0 O14908 O14908 GIPC1 PDZ domain-containing protein GIPC1 0 17282700.0 7561000.0 2667000.0 7054700.0 False True 7320980.193682153 3731947.0082212645 5206862.43353653 1.0 0.509760566138651 0.7112247671466095 22.803605390769697 -10.215423078879148 5.477506601127792 1.0000196331676063 0.6104926666425974 0.8328864847875477 0.08224741565128368 1.972048112227099e-05 2.8246621829773783e-06 0.07963972622264628 0.02654523925715153 6.089433906965725e-11 10.215423078879148 -0.38952696652500896 LVFHTQLAHGSPTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVFHTQLAHGSPTGR 15 0 O14908 O14908 GIPC1 PDZ domain-containing protein GIPC1 0 16499900.0 5994000.0 4458800.0 6047100.0 False True 8210143.781759361 4261795.472720152 4618899.523933807 1.0 0.5190890179278793 0.5625844865464729 22.968976057029426 -9.97530016441964 7.295104929876255 1.0000000153699375 0.5408367530651215 0.9933149895742208 0.017756950706466153 4.44318403025451e-09 6.145831905098169e-10 0.017193094231883525 0.005731031197130682 1.0585218705443154e-10 9.97530016441964 -0.4591632623048161 LVFHTQLAHGSPTGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVFHTQLAHGSPTGR 15 0 O14908 O14908 GIPC1 PDZ domain-containing protein GIPC1 0 14054700.0 7561000.0 3324900.0 3168800.0 False True 6287306.509093757 3306988.1037590248 3831381.4291242138 1.0 0.5259785090763277 0.6093835927328543 22.584010666203973 -10.806068265390172 7.2256068024553635 1.017160494990868 0.567681050904591 0.9728430764525612 0.034049982818772445 0.00904913908747308 0.0002428741299411533 0.03169471855019599 0.010989584699646195 1.562901955665897e-11 10.806068265390172 -0.44947944408627694 LVFLACCVAPTNPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVFLACCVAPTNPR 14 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 51784500.0 20617000.0 22525000.0 8642500.0 False True 27029086.655312013 19164357.80176233 7748257.004713916 1.0 0.7090272063631115 0.28666366361259027 24.68800942654235 -7.097053436003871 0.3699680650744858 1.0356810362002054 1.67239538887679e-11 0.9998798807582635 0.0032097131445861684 0.07604170561553839 0.017221214115186383 0.006488684294475387 0.03566742044388514 7.997358486978219e-08 7.097053436003871 -1.0356810361834814 down LVFLACCVAPTNPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVFLACCVAPTNPR 14 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 77162000.0 14403000.0 36687000.0 26072000.0 False True 21850404.000343807 30139918.213160686 20918857.772236455 1.0 1.3793757869505043 0.9573670936202052 24.381156618715636 -6.6698118744553225 1.9378624740461239 1.2421974549467671 0.9590702298361574 0.27818553568001747 0.16115855110104882 0.46161511091378227 3.341811744107163 0.06695207093563582 0.17893460068969272 2.1388884020035002e-07 6.6698118744553225 -0.2831272251106097 LVFLACCVAPTNPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVFLACCVAPTNPR 14 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 68071000.0 20617000.0 21181000.0 26273000.0 False True 28239662.05347559 20245153.38379958 20067858.509419903 1.0 0.7169049454438465 0.7106267232029448 24.751219488065242 LVFLACCVAPTNPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVFLACCVAPTNPR 14 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 67411000.0 14403000.0 27283000.0 25725000.0 False True 18644967.42557513 25764677.066315487 21043313.960790217 1.0 1.3818569096009423 1.1286323800129197 24.152282940808085 -10.248187870680136 4.724881828486494 0.9999284296450931 1.2552446448076555 0.5753159517809092 0.10337848131031258 7.796095971820438e-05 1.2405059795413518e-05 0.1001237890952582 0.033365261372235534 5.6469264257915834e-11 10.248187870680136 0.2553162151625624 LVFLGLDNAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVFLGLDNAGK 11 0 Q9NR31;X1WI22;D6RAA2;Q5SQT8;D6RDB2;Q9Y6B6;D6RD69 Q9NR31;Q9Y6B6 SAR1A;SAR1B GTP-binding protein SAR1a;GTP-binding protein SAR1b 0 41339000.0 10601000.0 15239000.0 15499000.0 False True 13898013.660230048 12965400.60115675 13895312.156906104 1.0 0.9328959460054337 0.999805619465487 23.728375368217065 -9.950919624910513 4.460274087771931 1.000000670879827 0.9663507827895967 0.2521788106677072 0.027315759832875732 37766097.402407065 22392587.458032776 299.73918843732133 0.009996543493644401 1.1196450775489842e-10 9.950919624910513 -0.033649888090230284 LVFLGLDNAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVFLGLDNAGK 11 0 Q9NR31;X1WI22;D6RAA2;Q5SQT8;D6RDB2;Q9Y6B6;D6RD69 Q9NR31;Q9Y6B6 SAR1A;SAR1B GTP-binding protein SAR1a;GTP-binding protein SAR1b 0 42448000.0 10601000.0 13963000.0 17884000.0 False True 14520476.18125309 13346068.490533685 13660167.532541608 1.0 0.9191205800650226 0.9407520360921635 23.791585429739957 -10.56105069378785 6.301636533375448 1.000120058809857 0.9299363080785931 0.9332795927773738 0.008831004943324497 1.4921126618099045e-05 1.0393558340440974e-06 0.008565210962993638 0.0028501945896476006 2.7475734190399905e-11 10.56105069378785 -0.07018375073126404 LVFSNVNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVFSNVNLK 9 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 19271200.0 4435100.0 6873300.0 7962800.0 False True 5814459.049569492 5847830.431913555 7138885.840571122 1.0 1.005739378686747 1.2277816009555853 22.47121354557882 -6.912448917281433 0.8788891338447813 0.993646073847839 1.2580326255174747 0.9918134145091829 0.009595410283491167 0.10282096536753722 0.13014689748925581 0.00795227092605189 0.0223429125319472 1.2233510039542048e-07 6.912448917281433 0.26438655166963576 LVFSNVNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVFSNVNLK 9 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 17968200.0 4435100.0 4945600.0 8587500.0 False True 6074876.324070888 4727087.039087827 6559309.365114124 1.0 0.7781371647612603 1.0797436878054183 22.53442360710171 -6.709591068938414 1.7967059306935886 0.8635462454960393 1.0790252168726042 0.4631372595506067 0.09349778336771021 0.3758995121348178 2.365191985854664 0.041416139025225465 0.10526695512669283 1.9516814352831542e-07 6.709591068938414 0.2154789713765649 LVFSNVNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVFSNVNLK 9 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 9799100.0 5301400.0 2423700.0 2074000.0 False True 4408348.991840975 2410643.047033216 2507663.810907476 1.0 0.546835799864045 0.5688442125495713 22.071807010308593 -10.142836344194468 5.237065723761528 1.0000143402606112 0.5578400062065084 0.9981452996245154 0.00898489685577163 1.5044408767561855e-06 2.4623574815373113e-07 0.008699870923640402 0.002899862990660315 7.197201400703881e-11 10.142836344194468 -0.4421743340541028 LVGIISSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVGIISSR 8 0 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 62693000.0 21412000.0 15843000.0 25438000.0 False True 28071339.354102965 13479286.155530306 22805919.778526187 1.0 0.48017965888614234 0.812427205230335 24.742594564307954 -10.104914256530376 5.249116259995092 1.0000070830729642 0.6463034320578739 0.6017591312949383 0.13563949280711987 1.1243494713546159e-05 1.917518758824094e-06 0.13133500148586966 0.04377745806064708 7.853906802702103e-11 10.104914256530376 -0.35370365101509027 LVGIISSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVGIISSR 8 0 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 28121600.0 13594000.0 2956600.0 11571000.0 False True 13162465.910979398 4137185.798465316 8540207.977440739 1.0 0.3143169240813992 0.6488303966141308 23.64992645908079 -10.589754641902003 6.550147784010144 1.0010654162963089 0.4815736603482573 0.7620449342699792 0.13656455329861805 0.002128577218855274 0.00013331585413131692 0.1324654954604221 0.04407602005065023 2.5718483584530398e-11 10.589754641902003 -0.5194917559480515 LVGIISSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVGIISSR 8 0 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 42297400.0 12460000.0 23402000.0 6435400.0 False True 18902730.94801665 19225730.25933947 5163440.3692639815 1.0 1.0170874416088915 0.2731584332160084 24.17209134524725 -6.901643374893165 0.950814952993102 1.029550664909556 0.19240971258284695 0.9873664661748182 0.03897256695572003 0.11020588710308785 0.1706738248924467 0.030643887406406015 0.08040854668063506 1.2541706265302363e-07 6.901643374893165 -0.837140952326709 down LVGIISSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVGIISSR 8 0 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 51288000.0 21412000.0 15062000.0 14814000.0 False True 29328595.03754277 14396511.036626676 11315238.303906899 1.0 0.49086944049648734 0.3858090811858719 24.805804625830845 -13.999999999999998 0.22183402493367807 4.09724821542445 0.33059020627653474 0.9994997965476259 0.005998819116708235 13.050158591905767 0.14919280717550493 17.723610130793308 0.05744765126535735 1.0000000000000041e-14 13.999999999999998 -3.7666580091479154 LVGIISSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVGIISSR 8 0 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 27565400.0 13594000.0 9904000.0 4067400.0 False True 11304013.316310085 9850645.186209926 4917874.534467251 1.0 0.8714290146842666 0.4350556211192229 23.430331734515065 -6.948649185164111 0.5734881087708866 1.005353592878354 0.2797876418516553 0.9990909208431179 0.007289866060613985 0.08403287272954604 0.03824346250107151 0.007692791654487384 0.03639015801389403 1.1255137755172573e-07 6.948649185164111 -0.7255659510266986 down LVGIISSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVGIISSR 8 0 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 38768000.0 12460000.0 15363000.0 10945000.0 False True 16129715.623319175 14508035.54483763 8953122.305183643 1.0 0.8994600948737721 0.5550700653543988 23.9432176673397 -6.948437872312712 0.5757374652890977 1.0041857869728492 0.433434543991256 0.9990729285477518 0.005800873005328888 0.08411913377250939 0.03860552163735554 0.00610620039195307 0.028736172187433563 1.1260615453043739e-07 6.948437872312712 -0.5707512429815932 LVGIVTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVGIVTSR 8 0 A0A3B3IRL5;C9J029;H7C5T1;H7C511;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 8776000.0 3054000.0 2165800.0 3556200.0 False True 4003823.57497807 1842671.082222278 3188238.5374791566 1.0 0.46022784164069236 0.7962984576553475 21.93294697378981 -10.440357708855393 6.303406387452479 1.0001103018565238 0.6282631496480279 0.619967878013816 0.13720025446312034 0.00021273681947270556 1.8887488461448136e-05 0.13288265022447762 0.04428119171925706 3.6277912681022373e-11 10.440357708855393 -0.37184715220849596 LVGIVTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVGIVTSR 8 0 A0A3B3IRL5;C9J029;H7C5T1;H7C511;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 7964300.0 3054000.0 1810900.0 3099400.0 False True 4183146.331246759 1730888.4501545096 2367385.554146691 1.0 0.41377669177511894 0.5659341956228215 21.996157035312702 -10.416617349356109 9.070693999549817 1.0000026062000413 0.4898554436992076 0.9374523893446304 0.06211804082707324 3.2740002960937646e-06 2.10458769824721e-07 0.060145841637211615 0.020048511468523926 3.8316219335105036e-11 10.416617349356109 -0.5101471625008338 LVGMPYLHEVLKPVISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVGMPYLHEVLKPVISR 17 1 O95294-2;O95294;O95294-4;O95294-3 O95294-2 RASAL1 RasGAP-activating-like protein 1 0 15043100.0 2938900.0 4912200.0 7192000.0 False True 2845606.228172525 6873667.076784596 5308199.444624815 1.0 2.4155369807434424 1.8654019632343126 21.440304606463712 -9.870262498628984 5.741103416432587 0.9999996275008842 2.1404694719912856 0.8514153371197186 0.2245916804309335 1.0705865822286862e-06 2.1109402113112395e-07 0.21746003078118767 0.07248665316590287 1.3481477814799846e-10 9.870262498628984 1.1404698444904013 LVGMPYLHEVLKPVISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVGMPYLHEVLKPVISR 17 1 O95294-2;O95294;O95294-4;O95294-3 O95294-2 RASAL1 RasGAP-activating-like protein 1 0 10943000.0 2938900.0 4711500.0 3292600.0 False True 2443825.5653452748 4686118.2143404735 3981067.4367376864 1.0 1.9175338374358963 1.6290309313362237 21.22070988189799 -10.042439879819831 4.845007909098046 0.999982712590667 1.7732823843973051 0.9054720056966268 0.11778081824948283 81518390.56483021 2.4241827613891442 16133.091850607341 0.04031950686680386 9.069014999295105e-11 10.042439879819831 0.7732996718066382 LVGQGASAVLLDLPNSGGEAQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVGQGASAVLLDLPNSGGEAQAK 23 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 31982200.0 4520200.0 14935000.0 12527000.0 False True 5926025.973679072 12706756.216174034 11230826.207469037 1.0 2.1442289103375733 1.8951699262459645 22.498633518947006 -10.165377131882696 4.759861331805187 0.99989679379398 2.0196994181127206 0.9571735537873755 0.10167790454807461 0.0001171787015048517 2.0547055736506788e-05 0.098459548387306 0.03281640257259897 6.833180110688874e-11 10.165377131882696 1.0198026243187406 LVGQGASAVLLDLPNSGGEAQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVGQGASAVLLDLPNSGGEAQAK 23 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 36367000.0 14118000.0 6901000.0 15348000.0 False True 13669831.817802496 9656605.28823959 11327898.369869515 1.0 0.7064172710350101 0.828678693406964 23.704492157549446 -10.06742342998118 4.959641153088172 1.0000055091955176 0.7675479823903519 0.8281719591780047 0.04991301667832214 13527035.987372503 27458115.144764986 526.1666313139799 0.017086551665232874 8.562026546334645e-11 10.06742342998118 -0.23245752680516563 LVGQGASAVLLDLPNSGGEAQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVGQGASAVLLDLPNSGGEAQAK 23 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 30560200.0 4520200.0 10755000.0 15285000.0 False True 6191440.093811924 10279808.53797104 11674997.8044564 1.0 1.6603259309970977 1.8856675712852418 22.561843580469898 -10.913853649767619 0.2117915201454157 2.422727393591154e-17 2.045410461303337 0.9993291053824577 0.009734542340535265 2.896167327675917 0.11490323319706583 1.55952132020238 0.12938065640042898 1.2194004479702633e-11 10.913853649767619 2.045410461303337 LVGQGASAVLLDLPNSGGEAQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVGQGASAVLLDLPNSGGEAQAK 23 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 21285700.0 14118000.0 2994200.0 4173500.0 False True 11739742.533446062 2978069.650297835 5046159.55391627 1.0 0.2536741876419719 0.4298356236978759 23.484897432983722 -10.65356728629854 9.917411556042547 1.0002413636322487 0.3417549056925983 0.9490218690908324 0.07191760511548193 0.0003839313354185325 1.3411373757805517e-05 0.06965733753951928 0.02321130724261524 2.2204076436526466e-11 10.65356728629854 -0.6584864579396503 LVGQGASAVLLDLPNSGGEAQAK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVGQGASAVLLDLPNSGGEAQAKK 24 1 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 1 18311700.0 5806600.0 7645800.0 4859300.0 True False 7612508.831194395 6505076.4430949725 4356506.249697005 1.0 0.8545246498025189 0.5722825872917212 22.85994056600002 -6.9606348948368355 0.4263926969345997 1.0116495959708913 0.40439832460268293 0.9997930227839121 0.0025545768203012907 0.07947511556518506 0.02029915029355622 0.0036684029730167126 0.02345512357524407 1.0948764264388191e-07 6.9606348948368355 -0.6072512713682083 LVGQGASAVLLDLPNSGGEAQAK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVGQGASAVLLDLPNSGGEAQAKK 24 1 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 1 19649700.0 5806600.0 8822700.0 5020400.0 True False 7953456.937464785 8432883.941232637 3834684.918383576 1.0 1.0602790720484712 0.48214065261613226 22.92315062752291 -6.881159283249935 1.0733521649230635 1.0379607272962552 0.4402530191126996 0.9746069018532657 0.041351658189497355 0.12660632232385127 0.2661442634659064 0.02964645227036862 0.07190617077807057 1.3147425445236795e-07 6.881159283249935 -0.5977077081835556 down LVGQSIIAYLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVGQSIIAYLQK 12 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IU89 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 15758900.0 3944800.0 5956500.0 5857600.0 False True 5171671.001497537 5067813.418255142 5251511.742066786 1.0 0.9799179833341445 1.015438093518735 22.302199069606715 -6.753291789265951 1.6375528409996805 0.9882390522535928 1.015527476497549 0.6631378639142347 0.008440310837985243 0.29429654601694305 1.5536455061211585 0.00406989561902623 0.009847125406740662 1.7648516720503712e-07 6.753291789265951 0.027288424243956277 LVGQSIIAYLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVGQSIIAYLQK 12 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IU89 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 14545200.0 6122700.0 2720600.0 5701900.0 False True 5928338.239896536 3806949.767741572 4208401.336666603 1.0 0.6421613635540493 0.7098787495532727 22.499196331930875 -10.759207738641946 6.981533643272984 1.0067517886041721 0.6760200565537853 0.9682734091621948 0.02764550706886448 0.0029313757198243216 0.00010110271089928239 0.02700757417257444 0.008922549039597627 1.7409739038683808e-11 10.759207738641946 -0.33073173205038686 LVGQSIIAYLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVGQSIIAYLQK 12 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IU89 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 26390600.0 3944800.0 8585800.0 13860000.0 False True 5403299.164211592 8206450.966556179 10586553.455660185 1.0 1.5187852304960432 1.9592758301778936 22.365409131129606 -6.973022043981726 0.1712502115763132 0.6173077388259198 2.872563678127895 0.9999973765762482 0.0006349884059151436 0.07533373595436825 0.0053488750249407226 0.018351843374089502 0.050823004895497396 1.0640890056708662e-07 6.973022043981726 2.2552559393019753 LVGQSIIAYLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVGQSIIAYLQK 12 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IU89 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 14567900.0 6122700.0 4088700.0 4356500.0 False True 5091296.331600097 4066673.3615565943 5267424.007819876 1.0 0.7987500818437957 1.034593876440978 22.27960160736515 -6.6806756778592264 1.8991216603916596 0.8727489267573476 1.033709583756528 0.327421167640482 0.08528107083325412 0.43700030148182384 3.047742210525836 0.03602199305078006 0.09493612005448916 2.086048119178911e-07 6.6806756778592264 0.16096065699918038 LVGQSIIAYLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVGQSIIAYLQK 12 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IU89 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 15854900.0 2240400.0 7914800.0 5699700.0 False True 2900241.964886377 7474334.422331644 4662413.083860679 1.0 2.5771416705310886 1.6075945180813003 21.46774183748833 -10.107419093373755 6.497344665484888 0.9999982663432848 2.092368094306197 0.6286034418109809 0.39581596751174153 9.939748287488487e-06 1.3650105101715787e-06 0.38324777338092597 0.12774905419466126 7.808738990162675e-11 10.107419093373755 1.0923698279629122 LVGQSIIAYLQK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVGQSIIAYLQKK 13 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IU89 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 7601180.0 1460300.0 5166700.0 974180.0 True False 1914467.441565318 4395848.499638862 873381.1985944109 1.0 2.2961207927593184 0.45620060160454434 20.8685116944944 -6.717410184684164 1.768225173561596 1.7907523889036534 0.45941927341996946 0.5002519795261029 0.5456011721914894 0.36047761066085243 2.2011577168272893 0.2451103761343307 0.617296104440661 1.9168574420647673e-07 6.717410184684164 -1.3313331154836838 LVGQSIIAYLQK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVGQSIIAYLQKK 13 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IU89 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 7657210.0 2707300.0 4041300.0 908610.0 True False 2621358.243401095 5655012.16510109 670617.7832842807 1.0 2.1572832249604943 0.25582836110724955 21.321883099892577 -6.741954328185693 1.6794247035175578 1.6870070349194217 0.2542040196255152 0.6137446903749965 0.48622539702262096 0.3142859100952852 1.7412259642539085 0.22896442951547194 0.5606826236369498 1.811530589026734e-07 6.741954328185693 -1.4328030152939064 LVGQSIIAYLQK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVGQSIIAYLQKK 13 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IU89 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 7222600.0 2707300.0 3300300.0 1215000.0 True False 2251239.9037256334 3282520.6288417433 1469050.8824747256 1.0 1.4580945475466287 0.6525519026397659 21.102288375326854 -6.752455964906267 1.6409101310424044 1.2685666313808641 0.6506604149295272 0.6594275910636485 0.19252139021925863 0.2957712802852752 1.5676449349359827 0.09265708734709131 0.22435574417531035 1.7682514997108614e-07 6.752455964906267 -0.6179062164513369 LVHANFGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVHANFGTK 9 0 P02786;G3V0E5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 0 5328500.0 1822700.0 1787300.0 1718500.0 False True 2389577.3510519085 1520641.8068408351 1540686.1050160103 1.0 0.6363643370537632 0.6447525560692938 21.188324037964346 -10.338488967866963 5.7189492909501976 1.0000592216133275 0.6405584465615268 0.9995917106033149 0.0034244760731330704 2.5862091985467246e-06 2.991512412478435e-07 0.0033162789771186913 0.0011052449000599437 4.586812972674997e-11 10.338488967866963 -0.35950077505180067 LVHANFGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVHANFGTK 9 0 P02786;G3V0E5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 0 3822790.0 1822700.0 752790.0 1247300.0 False True 2496601.4466154114 719529.2486563661 952713.4289498508 1.0 0.2882034894403415 0.381604132386218 21.251534099487237 -10.746687883864476 7.016051314813737 1.0111079432916412 0.33490381091327975 0.9854247652339585 0.03813065281087974 0.006525592752927104 0.00023560402160903492 0.0363644748505029 0.012306615276379513 1.7918931783647252e-11 10.746687883864476 -0.6762041323783614 LVHLPSCTVFSNFPVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVHLPSCTVFSNFPVIK 17 0 Q9Y5J1 Q9Y5J1 UTP18 U3 small nucleolar RNA-associated protein 18 homolog 0 5545000.0 1568900.0 2748800.0 1227300.0 False True 2056843.0932492148 2338689.7547384817 1100310.769092901 1.0 1.1370287614132155 0.5349512428557345 20.972000311059986 -6.8468875632773685 1.2501098205383387 1.0729716541847896 0.5123024976048068 0.9356336749568346 0.06537222269721472 0.1609205549195366 0.48552211639660103 0.040951041617617825 0.09458857598812033 1.4226970687779894e-07 6.8468875632773685 -0.5606691565799827 LVHLPSCTVFSNFPVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVHLPSCTVFSNFPVIK 17 0 Q9Y5J1 Q9Y5J1 UTP18 U3 small nucleolar RNA-associated protein 18 homolog 0 10065000.0 5296100.0 2952500.0 1816400.0 False True 5127978.2044385765 4131448.6470841006 1340630.349168037 1.0 0.8056681371048108 0.2614344865989563 22.289958699374587 -6.952986264017786 0.5250360279975389 1.0089009687067805 0.03370441163346622 0.999415282164741 0.007558810434263226 0.08230829488412823 0.031167597266333367 0.008496113360524643 0.044978050030905305 1.1143297773550852e-07 6.952986264017786 -0.9751965570733142 down LVHLPSCTVFSNFPVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVHLPSCTVFSNFPVIK 17 0 Q9Y5J1 Q9Y5J1 UTP18 U3 small nucleolar RNA-associated protein 18 homolog 0 14368600.0 1568900.0 6191700.0 6608000.0 False True 2148964.7279283064 5918130.220786179 5047326.496031924 1.0 2.7539447920541296 2.348724681441264 21.035210372582878 -10.169151262278117 5.104990226801466 0.9999110326401501 2.551334736749234 0.9513191182536485 0.16543041742462739 0.0001675204971529898 2.726394939038716e-05 0.1601863181472119 0.05339243763604267 6.774055300558802e-11 10.169151262278117 1.5514237041090837 LVHLQTLVLNGNPLLHAQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVHLQTLVLNGNPLLHAQLR 20 0 Q13045;Q13045-3;J3KS54;J3QLR6;J3QQQ2;J3KT47;J3QQU5 Q13045 FLII Protein flightless-1 homolog 0 71456000.0 33154000.0 22217000.0 16085000.0 False True 32101544.41758205 31088363.96012447 11871855.96034347 1.0 0.9684382643938259 0.36982195641158133 24.93613937183911 -6.917813973923117 0.8407849141560482 1.0142773880225018 0.27798340476413663 0.9935516779795011 0.023280679245633113 0.0994753155105603 0.11240695304841014 0.019829828007774268 0.0582128878956814 1.2083313019557552e-07 6.917813973923117 -0.7362939832583651 down LVHLQTLVLNGNPLLHAQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVHLQTLVLNGNPLLHAQLR 20 0 Q13045;Q13045-3;J3KS54;J3QLR6;J3QQQ2;J3KT47;J3QQU5 Q13045 FLII Protein flightless-1 homolog 0 535960000.0 178430000.0 187710000.0 169820000.0 False True 270691354.98030555 154211683.9150758 136255002.56524968 1.0 0.569695637033904 0.5033592689916642 28.012073572303052 -13.999999999999998 0.2632205629876 4.203638181763498 0.47985138528737636 0.9995689729509826 0.004570678220809812 14.561939711967439 0.16236680338627796 24.862549378672803 0.028517660475560404 1.0000000000000041e-14 13.999999999999998 -3.723786796476122 LVHLQTLVLNGNPLLHAQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVHLQTLVLNGNPLLHAQLR 20 0 Q13045;Q13045-3;J3KS54;J3QLR6;J3QQQ2;J3KT47;J3QQU5 Q13045 FLII Protein flightless-1 homolog 0 59756170.0 4070800.0 11440000.0 44245370.0 False True 5575884.769233559 10934542.97297895 33795524.86799881 1.0 1.9610417764214256 6.0610156534214426 22.410769316224005 -6.943397080991064 0.6271631625896913 0.9552659747142302 7.28668600702382 0.9985758630476904 0.08282004839856597 0.08625045739635612 0.047804754188624204 0.08286933703408378 0.3479428063556507 1.1392077190794292e-07 6.943397080991064 6.33142003230959 LVHLQTLVLNGNPLLHAQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVHLQTLVLNGNPLLHAQLR 20 0 Q13045;Q13045-3;J3KS54;J3QLR6;J3QQQ2;J3KT47;J3QQU5 Q13045 FLII Protein flightless-1 homolog 0 85262000.0 33154000.0 28652000.0 23456000.0 False True 27569019.971233197 28497645.9890233 28360541.151709642 1.0 1.0336836789540969 1.0287105302002884 24.716544647273388 -10.243432837687902 7.41858031418815 0.9999999238867909 1.0311971045771926 0.9812974946576131 0.0020302794769648104 2.555128360957537e-09 2.6060744954501293e-10 0.0019658144399971795 0.0006552698835359398 5.7090935872995126e-11 10.243432837687902 0.03119718069040167 LVHLQTLVLNGNPLLHAQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVHLQTLVLNGNPLLHAQLR 20 0 Q13045;Q13045-3;J3KS54;J3QLR6;J3QQQ2;J3KT47;J3QQU5 Q13045 FLII Protein flightless-1 homolog 0 464249000.0 178430000.0 167399000.0 118420000.0 False True 230981152.3811266 158083098.49445271 96868775.09180869 1.0 0.6843982587532091 0.4193795644935219 27.7831998943955 -7.316608401079821 0.19738097392205312 1.1873181233750794 2.31990649789085e-12 0.999978085962991 0.001111016967596203 0.10941345718972612 0.012588981595842022 0.020358489530512676 0.04849942599790269 4.823825610371638e-08 7.316608401079821 -1.1873181233727594 down LVHSLFESIMSTQESSNPNNVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVHSLFESIMSTQESSNPNNVLK 23 0 O15067 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 13303500.0 5271700.0 4091400.0 3940400.0 False True 5104352.769082686 5725117.356369142 2908291.030533875 1.0 1.12161475026696 0.5697668562701105 22.28329660857959 -6.848923730397957 1.2402269154521797 1.0648461915059682 0.548155245615813 0.9387244853732226 0.05860319644083983 0.1586516449171809 0.47013504158819086 0.03698378880692253 0.08552834612823562 1.4160424395992834e-07 6.848923730397957 -0.5166909458901552 LVHSLFESIMSTQESSNPNNVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVHSLFESIMSTQESSNPNNVLK 23 0 O15067 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 11832300.0 5271700.0 2937700.0 3622900.0 False True 4383652.125907888 2921874.0270122024 4380431.6396030355 1.0 0.6665387542372697 0.9992653417259507 22.063701884013867 -10.973644079994813 9.450617306198664 1.0941654125445988 0.8329020479816103 0.251655987025866 0.13583506053412897 0.08163389570099414 0.00022766081113353705 0.03983850436793434 0.043840577273313135 1.0625660116689036e-11 10.973644079994813 -0.2612633645629885 LVIIEGDLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVIIEGDLER 10 0 J3KN67;A0A2R2Y2Q3;P06753;P06753-7;A0A494C0P6;P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 41532300.0 12318000.0 5903300.0 23311000.0 False True 11926971.832532307 8260518.475302814 17205149.784990117 1.0 0.692591429852397 1.442541327888519 23.50772446443375 -6.79540552483814 1.4745545818640375 0.8293836939115184 1.4517604812367857 0.8183769170803695 0.1311836284811514 0.22739683419951107 0.9765282491284921 0.07000375694726074 0.16328267613968744 1.6017490502901047e-07 6.79540552483814 0.6223767873252672 LVIIEGDLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVIIEGDLER 10 0 J3KN67;A0A2R2Y2Q3;P06753;P06753-7;A0A494C0P6;P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 77478200.0 9048200.0 57727000.0 10703000.0 False True 13726780.912026025 47425165.82689036 8587547.35870845 1.0 3.45493718671806 0.6256053341089538 23.710490000784066 -6.6772867630372845 1.9117320147904584 2.557041169430708 0.6366396364972235 0.3116922177191994 1.0410839700534675 0.4445607879590003 3.138937033562703 0.4373759004860277 1.1574882900709431 2.1023897811709802e-07 6.6772867630372845 -1.9204015329334845 LVIIEGDLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVIIEGDLER 10 0 J3KN67;A0A2R2Y2Q3;P06753;P06753-7;A0A494C0P6;P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 13851400.0 5487700.0 0.0 8363700.0 False True 7516650.98951632 0.0 6388366.315808438 1.0 0.0 0.8498952957531842 22.8416585880082 -9.459799066966744 11.206318846086084 1.0001540934550324 0.42494764787790645 0.379040629074739 0.34696831297035813 0.0 0.0 0.33595061929526276 0.11198353976508756 3.4689731071543526e-10 9.459799066966744 -0.575206445577126 LVIIEGDLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVIIEGDLER 10 0 J3KN67;A0A2R2Y2Q3;P06753;P06753-7;A0A494C0P6;P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 25093700.0 12318000.0 6417800.0 6357900.0 False True 10242962.779925525 6383226.037566435 7687307.494391822 1.0 0.623181610117385 0.750496478368314 23.288129739868026 -10.344408217657515 4.941434568598664 1.0001803863677365 0.6868390442427533 0.8897107604884578 0.05197607731440652 0.00010334994101602274 1.3711649580609918e-05 0.050354393898767814 0.016775206819942937 4.52472076163217e-11 10.344408217657515 -0.3133413421249832 LVIIEGDLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVIIEGDLER 10 0 J3KN67;A0A2R2Y2Q3;P06753;P06753-7;A0A494C0P6;P06753-2;P06753-5;A0A087WWU8;P06753-3;P06753-6;P06753-4 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 32613900.0 9048200.0 16923000.0 6642700.0 False True 11713073.266686724 15981220.173487406 5433796.759857779 1.0 1.3643917193739208 0.46390871431771014 23.481616322876516 -6.796854838853373 1.468636062988751 1.2018650447366384 0.45241280079575635 0.8228084745104511 0.15568155241400009 0.22529232871499266 0.9596282677229887 0.08340429756308011 0.19435823021993237 1.5964126524423062e-07 6.796854838853373 -0.749452243940882 down LVIITAGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVIITAGAR 9 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 P00338 LDHA L-lactate dehydrogenase A chain 0 503245200.0 139630000.0 172035200.0 191580000.0 False True 183056282.1788436 146368218.7479572 171757139.3651248 1.0 0.7995804186876109 0.9382750338899614 27.447712044419827 -10.076609696248939 5.337679425876386 1.0000015443630488 0.8689277262886603 0.5435470921050523 0.056621839553343635 1.0405941773846025e-06 1.8006918539519654e-07 0.0548245061823503 0.018274620135080365 8.382823143842811e-11 10.076609696248939 -0.13107381807438845 LVIITAGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVIITAGAR 9 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 P00338 LDHA L-lactate dehydrogenase A chain 0 246884900.0 87961000.0 68951900.0 89972000.0 False True 85168726.2024172 96484753.2494084 66405634.09785656 1.0 1.1328659890967119 0.7796950483917403 26.343820436970244 -6.8047868679926475 1.4361951422473358 1.0728708131952946 0.7742189952945677 0.845800195286453 0.05719306365909675 0.21400453549040613 0.8708839599134757 0.031320491321642684 0.07264124890448853 1.5675201490752558e-07 6.8047868679926475 -0.2986518179007269 LVIITAGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVIITAGAR 9 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 P00338 LDHA L-lactate dehydrogenase A chain 0 1731900000.0 423950000.0 681840000.0 626110000.0 False True 643163144.8966012 560160324.7597642 502359084.06623805 1.0 0.8709459321550816 0.781075669606349 29.260609497397002 -6.974996568465819 0.06963223984499528 1.3862863105994037 0.2634905798676394 0.999999939176321 2.139422779099549e-05 0.07471293248701477 0.0020095243459144424 0.012841185599929722 0.01946101465622339 1.0592620947971569e-07 6.974996568465819 -1.1227957307317642 LVIITAGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVIITAGAR 9 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 P00338 LDHA L-lactate dehydrogenase A chain 0 287640200.0 139630000.0 143886200.0 4124000.0 False True 191254984.3588688 137528831.91596535 3149996.1364460737 1.0 0.719086262650848 0.016470138788829965 27.51092210594272 -7.378606724408094 0.7384882030917008 0.9917926797272649 2.963076535830724e-18 0.989600536605456 0.04218249753300391 0.1100724367458542 0.12503225127876372 0.036836665539919086 0.07094314875439933 4.1820890451718666e-08 7.378606724408094 -0.9917926797272649 down LVIITAGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVIITAGAR 9 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2;F5GXH2 P00338 LDHA L-lactate dehydrogenase A chain 0 225237300.0 87961000.0 64114500.0 73161800.0 False True 73143468.83301103 63769102.46276813 88459594.1180572 1.0 0.8718359066119097 1.2093983991928712 26.12422571240452 -6.803796916338796 1.440165866884444 0.92962389371297 1.2145180377312765 0.8430974250080231 0.055111911799504684 0.21537251187473533 0.8814249163433272 0.030098579548471605 0.06984885187908474 1.5710973050415934e-07 6.803796916338796 0.2848941440183065 LVIK(ub)NQQFHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVIKNQQFHK 10 1 Q15233;Q15233-2;H7C367 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 29256400.0 10083000.0 10591000.0 8582400.0 True False 13218910.6439109 9010864.083394645 7694375.576194002 1.0 0.6816646489357555 0.5820733480590026 23.656099955022118 -13.999999999999998 0.16268170486117914 2.5769693774119293 0.48701034355555656 0.9995295721925233 0.0038658579270860944 12.028654945771283 0.127546557938915 5.9845120256898765 0.08694257445837597 1.0000000000000041e-14 13.999999999999998 -2.0899590338563727 LVIK(ub)NQQFHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVIKNQQFHK 10 1 Q15233;Q15233-2;H7C367 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 54885000.0 11889000.0 16898000.0 26098000.0 True False 11511590.202709582 23645459.52190585 19262150.876782328 1.0 2.0540567467681585 1.673283233470944 23.456583804293132 -10.120813452802917 4.607241905610606 0.9999263872605212 1.8636699901387146 0.8727676092513054 0.15545013592857015 108429714.50668103 13.456197185692428 88414.9640453351 0.053214716248828495 7.571580554543283e-11 10.120813452802917 0.8637436028781934 LVIK(ub)NQQFHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVIKNQQFHK 10 1 Q15233;Q15233-2;H7C367 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 188038000.0 23147000.0 42951000.0 121940000.0 True False 35115691.27237085 35286058.47230528 97838505.5517993 1.0 1.00485159749848 2.786176264990089 25.065612499935234 -6.907496173481517 0.9126195029213336 0.9403848500777421 3.0044649056072767 0.9899418309840559 0.08433124483943924 0.1060970161729296 0.14792189875854575 0.06819952736761534 0.1851497350096581 1.2373820923179171e-07 6.907496173481517 2.0640800555295344 up LVIK(ub)NQQFHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVIKNQQFHK 10 1 Q15233;Q15233-2;H7C367 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 32179000.0 10083000.0 9791000.0 12305000.0 True False 13810957.582829429 9358401.245492736 9398812.429429902 1.0 0.6776069790502893 0.6805330023687164 23.71931001654501 -10.230339636859929 5.406076487540427 1.000022159832295 0.6790699917337519 0.9999376582138193 0.0011945440177203483 3.190679928196334e-07 4.542488570331889e-08 0.0011566920436908504 0.00038553742389540796 5.883833344506218e-11 10.230339636859929 -0.320952168098543 LVIK(ub)NQQFHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVIKNQQFHK 10 1 Q15233;Q15233-2;H7C367 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 47805000.0 11889000.0 22036000.0 13880000.0 True False 9886230.272003133 21917287.694196466 16782243.826131023 1.0 2.21695096019199 1.6975372173614798 23.236989079727408 -10.5290610274056 5.636975376980374 0.9978799246303744 1.9572440887767355 0.8191200919801006 0.21204977255399463 0.00565805157887558 0.00047269932671163814 0.205614309101347 0.068438769805724 2.9575968334931325e-11 10.5290610274056 0.959364164146361 LVIK(ub)NQQFHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVIKNQQFHK 10 1 Q15233;Q15233-2;H7C367 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 322849000.0 23147000.0 34612000.0 265090000.0 True False 29964247.79558335 32685811.773606766 216846340.05309537 1.0 1.0908270414992554 7.236835762820582 24.836738822027684 -6.910116839215029 0.8949452942528768 0.8104101651014122 8.033074840206085 0.9909654373805207 0.2774423647836544 0.10434062809814974 0.13835096736593538 0.22727711733688372 0.6278914185116872 1.229937833373976e-07 6.910116839215029 7.222664675104673 up LVILANNCPALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVILANNCPALR 12 0 P62888;E5RI99;E5RJH3 P62888 RPL30 60S ribosomal protein L30 0 90567000.0 34019000.0 44359000.0 12189000.0 False True 44599238.440464616 37740810.110027745 10927799.205144094 1.0 0.8462209542077234 0.24502210323011633 25.410515739658788 -6.945401390432825 0.6072439891137714 1.0066781635653104 0.0534045203471796 0.9987891192070472 0.011335721994041046 0.08538674128877159 0.04402292147104597 0.011552762693250875 0.05064593742668716 1.1339622828596641e-07 6.945401390432825 -0.9532736432181308 down LVILANNCPALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVILANNCPALR 12 0 P62888;E5RI99;E5RJH3 P62888 RPL30 60S ribosomal protein L30 0 43816600.0 28407000.0 6820100.0 8589500.0 False True 27505235.33420567 9543401.496351661 6339652.27052347 1.0 0.3469667276208843 0.2304889303251822 24.71320291091552 -13.999999999995637 0.2424816674962807 5.375019015549112 0.18018751637809374 0.9995291482020081 0.007348448834320177 13.71233442817776 0.15584173100673165 29.09135020821099 0.056097248132297016 1.0000000000100455e-14 13.999999999995637 -5.194831499171018 LVILANNCPALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVILANNCPALR 12 0 P62888;E5RI99;E5RJH3 P62888 RPL30 60S ribosomal protein L30 0 113596000.0 16799000.0 79609000.0 17188000.0 False True 25485311.171406988 65402151.96204409 13790784.266231988 1.0 2.5662685270808634 0.5411267758701895 24.603162632628656 -6.7001853895681 1.830084756508426 1.9724024220633065 0.5471042587351546 0.41852025800075676 0.6611175461095197 0.3951337551478462 2.5729542102296876 0.28817580246850105 0.7409765978865239 1.9944107686225464e-07 6.7001853895681 -1.425298163328152 LVILANNCPALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVILANNCPALR 12 0 P62888;E5RI99;E5RJH3 P62888 RPL30 60S ribosomal protein L30 0 102613000.0 34019000.0 29602000.0 38992000.0 False True 46596743.62890749 28294085.759276483 29782892.66544745 1.0 0.6072116537715206 0.6391625325287938 25.47372580118168 -9.85408044521758 5.406697749898731 1.0000002401513035 0.6231870936904074 0.9946366040280517 0.013043891646016053 3.775757059501891e-08 8.005882668971788e-09 0.012629701676540074 0.0042098979241254565 1.3993280982803963e-10 9.85408044521758 -0.37681314646089614 LVILANNCPALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVILANNCPALR 12 0 P62888;E5RI99;E5RJH3 P62888 RPL30 60S ribosomal protein L30 0 44149600.0 28407000.0 3795600.0 11947000.0 False True 23621679.143476587 3775152.3494323906 14445062.463313213 1.0 0.1598172732134051 0.6115171735072183 24.493608186349796 -10.351804967726528 6.620061437280397 1.0000314277109354 0.3856672234768397 0.7115080508816232 0.18440571209764672 8.554095306501037e-05 8.37524723854313e-06 0.1785591583206293 0.05951668765830874 4.448309866111818e-11 10.351804967726528 -0.6143642042340958 LVILANNCPALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVILANNCPALR 12 0 P62888;E5RI99;E5RJH3 P62888 RPL30 60S ribosomal protein L30 0 61490000.0 16799000.0 26564000.0 18127000.0 False True 21746636.65779601 25085690.048367314 14828071.99872672 1.0 1.1535434395265107 0.6818558764769247 24.374288954721106 -6.819045775036645 1.3760216211455074 1.0828385611041005 0.6717692181924767 0.8821755872871352 0.0674274196164836 0.19471993280236397 0.7247163064784625 0.03850974010622593 0.08878110354551877 1.5168904773858855e-07 6.819045775036645 -0.4110693429116238 LVINGNPITIFQER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVINGNPITIFQER 14 0 P04406;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 874950000.0 214900000.0 376230000.0 283820000.0 False True 281735981.09456056 320097950.53305334 254453028.9936825 1.0 1.1361628333358569 0.9031612788864163 28.06976858419547 -6.7482856856631495 1.6560305584934851 1.0802281705504693 0.902753295807105 0.6416477906664106 0.05721241046712759 0.30303410145198384 1.6345286828410435 0.027296816072843684 0.0663931354341861 1.785312781987641e-07 6.7482856856631495 -0.17747487474336432 LVINGNPITIFQER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVINGNPITIFQER 14 0 P04406;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 1552500000.0 524880000.0 441510000.0 586110000.0 False True 508217971.70478624 617807245.4442335 432590208.0768975 1.0 1.215634392801649 0.8511903005432885 28.920872152260603 -6.746398218266555 1.6631253293833081 1.1273444574932414 0.8506593815257516 0.633305223921919 0.09059989457083527 0.30639201730024995 1.6662331477823515 0.04305406648684866 0.10492399295083518 1.7930887333784036e-07 6.746398218266555 -0.2766850759674898 LVINGNPITIFQER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVINGNPITIFQER 14 0 P04406;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 621636000.0 75787000.0 452020000.0 93829000.0 False True 114974419.77185684 371353499.35162026 75283657.02328832 1.0 3.229879307836431 0.6547861443673584 26.776737676152454 -6.6776811671903555 1.9100360166779369 2.413791131562858 0.6647366390416852 0.313574678590787 0.945557820980217 0.44370020893445666 3.127571021177935 0.3975176455079297 1.051585669970968 2.1004813644286617e-07 6.6776811671903555 -1.7490544925211728 LVINGNPITIFQER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVINGNPITIFQER 14 0 P04406;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 1464340000.0 214900000.0 515340000.0 734100000.0 False True 294354337.4541353 492570574.7985116 560720699.2640795 1.0 1.673393295504814 1.9049174002793416 28.13297864571836 -10.867986001127552 0.21218742920203157 1.1629444734852126e-15 2.069256635707457 0.999326191292532 0.009963421404500124 2.814270670239982 0.11428886783417475 1.5342229927027407 0.13245689232283137 1.3552330956817588e-11 10.867986001127552 2.0692566357074558 LVINGNPITIFQER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVINGNPITIFQER 14 0 P04406;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 974640000.0 524880000.0 215900000.0 233860000.0 False True 436460976.1265879 214736903.84720558 282759044.75353044 1.0 0.4919956550363505 0.6478449625964294 28.70127742769488 -10.883426637832464 11.136525314202311 1.021643462257245 0.569920308816408 0.9103441266857395 0.06362521338137903 0.02745739931985908 0.0002874141917970767 0.049472795523396354 0.020534949318747855 1.3078964535740489e-11 10.883426637832464 -0.451723153440837 LVINGNPITIFQER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVINGNPITIFQER 14 0 P04406;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 246994000.0 75787000.0 107590000.0 63617000.0 False True 98107765.48511149 101602521.92078905 52039358.76554297 1.0 1.0356216087319603 0.5304305781323732 26.547863998244903 -6.889978098958539 1.0225310279182398 1.027158841131774 0.4870011308321854 0.9808835940532831 0.03182973336173323 0.1191601662608504 0.221960749667595 0.023719249958435842 0.05912677248000536 1.288314518482797e-07 6.889978098958539 -0.5401577102995887 LVINGNPITIFQERDPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVINGNPITIFQERDPSK 18 1 P04406;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 195668800.0 58584200.0 55865700.0 81218900.0 False True 76804453.53019977 47530755.32279307 72815147.33470158 1.0 0.6188541567332917 0.9480589209071115 26.19468663270549 -10.147571544301048 7.419542090785324 1.0000001025454202 0.7834565388202016 0.3658423065561466 0.13439728218652114 2.2796856863979815e-07 2.6134822176842012e-08 0.1301296709712368 0.04337653630699458 7.119155116261074e-11 10.147571544301048 -0.21654356372521855 LVINGNPITIFQERDPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVINGNPITIFQERDPSK 18 1 P04406;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 149836000.0 88811000.0 25948000.0 35077000.0 False True 85991743.41768362 36309171.71703241 25889281.412556235 1.0 0.42224020904739185 0.30106706043631953 26.357694808884382 -13.99999999999996 0.21953765563753366 4.479400807044813 0.2359634362263668 0.9994974332442078 0.006836554906617821 12.987071381567125 0.14843670230266592 19.585200204528498 0.0672651696762538 1.000000000000094e-14 13.99999999999996 -4.243437370818446 LVINGNPITIFQERDPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVINGNPITIFQERDPSK 18 1 P04406;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 504719000.0 37709000.0 373170000.0 93840000.0 False True 57207309.89717174 306574897.90948194 75292482.86846697 1.0 5.359016154763093 1.316133952178537 25.769696169232585 -6.62832116251628 2.086301597665016 3.8752480430636043 1.3322078577454968 0.11156568307009895 1.8705708440618671 0.5633885956618874 4.670805512712129 0.7338332143160681 2.0726965189810875 2.3533083592673035e-07 6.62832116251628 -2.5430401853181075 LVINGNPITIFQERDPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVINGNPITIFQERDPSK 18 1 P04406;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 271616100.0 58584200.0 102392700.0 110639200.0 False True 80244361.91847616 97868651.94662082 84508499.64584965 1.0 1.2196327518442973 1.0531394060022012 26.257896694228382 -10.603725313275437 4.5162309734747605 0.997786385306721 1.1363860789232776 0.4722163334484546 0.06797062381374297 0.0015387484556385431 0.00013501666414326408 0.06684569325930684 0.02193742450514913 2.49043199247562e-11 10.603725313275437 0.13859969361655655 LVINGNPITIFQERDPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVINGNPITIFQERDPSK 18 1 P04406;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 144022600.0 88811000.0 29813600.0 25398000.0 False True 73850281.49439567 29652988.21926371 30708604.372916143 1.0 0.40152843860878185 0.41582244172280575 26.13810008431866 -9.911169521487915 5.745490701676352 1.00000032806545 0.40867544020485924 0.9995619463399741 0.005835502337709704 2.4516354873625e-08 4.645330424310698e-09 0.005650203956661189 0.0018834002805240384 1.2269602089084444e-10 9.911169521487915 -0.5913248878605907 LVINGNPITIFQERDPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVINGNPITIFQERDPSK 18 1 P04406;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 221908700.0 37709000.0 102282700.0 81917000.0 False True 48815043.85551708 96590577.83128063 67008946.53939962 1.0 1.9787051327285443 1.372710976922051 25.540822491325034 -10.270292992125636 6.05507324114228 0.999974221367544 1.6757080548252845 0.623742438160106 0.24739607813909778 8.61110654962684e-05 1.0377647772877976e-05 0.2395493293357096 0.07984674087914548 5.3666961579897325e-11 10.270292992125636 0.6757338334577405 LVINGNPITIFQERDPSKIK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVINGNPITIFQERDPSKIK 20 2 P04406;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 61592300.0 10371000.0 9622300.0 41599000.0 True False 15733565.221659735 7905125.385626946 33376939.416510604 1.0 0.5024370048528031 2.1213843745066745 23.907342286319437 -6.824207482186423 1.3536777415451746 0.7329021344327759 2.159988529263355 0.8937664221036847 0.2206874045770661 0.18807096049663544 0.6760143048491278 0.12807553381354334 0.2948994109439691 1.498968539103756e-07 6.824207482186423 1.4270863948305794 up LVINGNPITIFQERDPSKIK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVINGNPITIFQERDPSKIK 20 2 P04406;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 63572000.0 10371000.0 15303000.0 37898000.0 True False 13425463.942972941 14451374.597581886 31000952.866317894 1.0 1.0764152850856166 2.309115945489853 23.678468608411887 -6.919562787456121 0.8279708446934047 0.9723704594724246 2.5059095861739027 0.9940584710805188 0.04624289769969852 0.09842955889263912 0.10695480971728043 0.039751048183325415 0.11857873739699776 1.2034753866121383e-07 6.919562787456121 1.533539126701478 up LVIPSELGYGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVIPSELGYGER 12 0 A0A494C1N0;P26885 A0A494C1N0 FKBP2 Peptidyl-prolyl cis-trans isomerase FKBP2 0 10873800.0 1214200.0 4240700.0 5418900.0 False True 1591827.9583295265 3608004.090119129 4858204.209759234 1.0 2.2665791684582484 3.0519656250148177 20.60225298995635 -8.544465699324686 0.19394464882441487 4.498726813307435e-18 4.011007753244139 0.9997184686165081 0.014184114360661026 0.18074292923794355 0.0514040044618835 0.49291912116727715 0.3989589770465891 2.854527956140134e-09 8.544465699324686 4.011007753244139 LVIPSELGYGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVIPSELGYGER 12 0 A0A494C1N0;P26885 A0A494C1N0 FKBP2 Peptidyl-prolyl cis-trans isomerase FKBP2 0 11847500.0 1214200.0 5504000.0 5129300.0 False True 1663122.5525212234 5260815.080705959 3917864.981249473 1.0 3.163215526559234 2.3557283708949504 20.665463051479243 -10.321537943346652 5.809627631848416 0.9997987339920058 2.7594719487270987 0.8635820764146108 0.3296552508714945 0.0008594625072012546 0.00010037022270490694 0.31922149207750755 0.10639577471792376 4.7693814327004e-11 10.321537943346652 1.7596732147350929 LVIWGTDVNVAACK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVIWGTDVNVAACK 14 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 11602300.0 2446400.0 3655900.0 5500000.0 False True 3350900.1914741537 3494370.249555402 4201013.276055622 1.0 1.0428153779233071 1.2536969279910064 21.676117284989292 -6.940141277054203 0.6582477485778664 0.9976385586355309 1.3108021279979962 0.9981823491643895 0.004727607127041469 0.0877022238644794 0.05431656605387826 0.0046069146860362835 0.018138882244206015 1.1477801850666579e-07 6.940141277054203 0.31316356936246537 LVIYGGMSGCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVIYGGMSGCR 11 0 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 29823000.0 13194000.0 16629000.0 0.0 False True 17297461.77087776 14148018.019334318 0.0 1.0 0.8179245144021138 0.0 24.044057016569084 -7.22346154490334 0.8733684858165262 0.9898931558729313 5.553333171745153e-16 0.9891097758460768 0.045383325938152905 0.09541317040343687 0.13919550674786565 0.03834216098085649 0.06738902816013234 5.977759730957732e-08 7.22346154490334 -0.9898931558729307 down LVIYGGMSGCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVIYGGMSGCR 11 0 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 9717600.0 1992500.0 3955500.0 3769600.0 False True 2579330.528046823 3735372.9478360526 3083571.4793622876 1.0 1.4481947572126916 1.1954929567314108 21.298565228306167 -10.247100000068992 5.170601323634439 0.9999685679077412 1.3218438566760644 0.683822541813633 0.10316507819744987 4.8979718878574723e-05 7.132091612547453e-06 0.09990191453164386 0.033296385790909114 5.661089225432842e-11 10.247100000068992 0.32187528876832316 LVK(ub)ENNYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVKENNYR 8 1 Q96J01;Q96J01-2 Q96J01 THOC3 THO complex subunit 3 1 5071130.0 1228080.0 965130.0 2877920.0 True False 1610024.7727436377 821136.3660472746 2580140.4453579737 1.0 0.5100147401135815 1.6025470471247254 20.618651455949433 -6.78477377328651 1.5170836603880853 0.7242759863527329 1.6125616074670737 0.7839689551612274 0.20767476013426334 0.24323172537922272 1.1059195236890078 0.10778282039324333 0.25334683907456396 1.6414445892996045e-07 6.78477377328651 0.8882856211143407 LVK(ub)ENNYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVKENNYR 8 1 Q96J01;Q96J01-2 Q96J01 THOC3 THO complex subunit 3 1 6969830.0 843750.0 1596780.0 4529300.0 True False 816965.6180954003 2234382.581097695 3342940.453912569 1.0 2.734977496735704 4.091898581614729 19.63991583842955 -7.63383873538746 0.2057393775294466 1.8396915984837843e-17 5.957955431453607 0.9999120735746936 0.011865574080815214 0.13734765806997587 0.02462104705747393 0.21422761312482927 0.3961344015405579 2.323599447895144e-08 7.63383873538746 5.957955431453607 LVK(ub)ENNYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVKENNYR 8 1 Q96J01;Q96J01-2 Q96J01 THOC3 THO complex subunit 3 1 21933710.0 799910.0 1246100.0 19887700.0 True False 1213521.9512542535 1023723.7191762631 15956887.377911434 1.0 0.8435971991426924 13.149236700184085 20.21076877478827 -6.904020922554195 0.9354820280779427 0.543275251824593 14.551872206856471 0.9884631788442123 0.6191543672988866 0.10850627933354594 0.1611913995785355 0.49237855628255955 1.3089887843313794 1.2473234217904318e-07 6.904020922554195 14.008596955031878 up LVK(ub)ENNYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVKENNYR 8 1 Q96J01;Q96J01-2 Q96J01 THOC3 THO complex subunit 3 1 6061570.0 1228080.0 745490.0 4088000.0 True False 1682134.3636141196 712551.7867942374 3122498.5950028026 1.0 0.42359980403901687 1.8562718071426911 20.681861517472324 -6.797516260703735 1.466146281971754 0.6809668334453853 1.8748315420251378 0.8247691974181539 0.24638891574559454 0.22432307525838444 0.9522399508331462 0.13222571202387415 0.30796965608257415 1.5939831982274947e-07 6.797516260703735 1.1938647085797525 LVK(ub)ENNYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVKENNYR 8 1 Q96J01;Q96J01-2 Q96J01 THOC3 THO complex subunit 3 1 5375280.0 843750.0 1659470.0 2872060.0 True False 701615.5094627512 1650530.1057309932 3472594.4670949536 1.0 2.352470952352315 4.94942660226258 19.420321113863825 -6.960833787756296 0.4235193427733711 0.8894670358949321 6.510961945849328 0.9997998831023697 0.02318306525876432 0.07940461625870487 0.020040698922291985 0.03367607401514198 0.21597230248910076 1.0943751230114942e-07 6.960833787756296 5.621494909954396 LVK(ub)ENNYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVKENNYR 8 1 Q96J01;Q96J01-2 Q96J01 THOC3 THO complex subunit 3 1 13267840.0 799910.0 1157630.0 11310300.0 True False 1035499.2635834063 1093206.8728614452 9251941.453478167 1.0 1.0557292615335507 8.934763914231361 19.98189509688072 -6.908450555014817 0.9062176002170662 0.7439343758753358 9.91997186311659 0.9903236965030501 0.3666593641356165 0.10545167045241442 0.1443895253583129 0.2979079185684846 0.8137986262838287 1.234665875466514e-07 6.908450555014817 9.176037487241254 up LVK(ub)LFDFPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVKLFDFPGR 10 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 6986200.0 3130100.0 2804200.0 1051900.0 True False 3030736.6888301144 3923931.6837098147 776375.8336764247 1.0 1.2947121728428608 0.2561673656895978 21.531237085181004 -6.830880692509998 1.3238114348818655 1.1573921769427222 0.22768611441051156 0.9076371971164037 0.13280962639970442 0.1797404645496325 0.6157044058747116 0.07875849984364544 0.1812570654310308 1.4761119886422998e-07 6.830880692509998 -0.9297060625322107 down LVK(ub)LFDFPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVKLFDFPGR 10 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 11800200.0 4023800.0 0.0 7776400.0 True False 6104398.779183736 0.0 6239391.131482794 1.0 0.0 1.0221139472013834 22.541417780834536 -12.090117217055912 18.273238495367778 0.8870448203634863 0.5599512762406325 0.0 0.49016413763668204 0.0 0.0 0.0 0.1411016695067296 8.126111609860634e-13 12.090117217055912 -0.32709354412285385 LVK(ub)LFDFPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVKLFDFPGR 10 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 5118600.0 1436700.0 2143800.0 1538100.0 True False 1967886.815357635 2049079.8274014236 1174832.458163846 1.0 1.041258984719115 0.5970020475747418 20.908215814585645 -6.884171471564891 1.0562130172971183 1.0273108323335813 0.5628804935827381 0.9768993164228661 0.03045997997886296 0.12400121878341387 0.25047606045045134 0.022124344210782118 0.054119192337619616 1.30565527725875e-07 6.884171471564891 -0.4644303387508433 LVK(ub)LFDFPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVKLFDFPGR 10 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 8222700.0 3130100.0 2895500.0 2197100.0 True False 2602816.8369414574 2879901.3667882513 2656503.451757387 1.0 1.106455639103823 1.0206263514412393 21.31164236061528 -10.125368218957629 4.176399905023855 0.9999862501934167 1.0635409952158175 0.4222196831074724 0.03503965999516929 24451893.54668348 0.09458361828027036 3323.308129070616 0.011995007611498035 7.492586768734692e-11 10.125368218957629 0.06355474502240077 LVK(ub)LFDFPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVKLFDFPGR 10 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 16557800.0 4023800.0 4645200.0 7888800.0 True False 5208888.420955992 4386690.536541029 6453119.345923501 1.0 0.8421548288292832 1.2388668799204483 22.312544102926985 -6.798730687661121 1.4609993252393783 0.9127688561705326 1.244178740442355 0.8284512650701243 0.06754479427345861 0.22257409639627587 0.9380547960057342 0.036372053482712295 0.08465763881006612 1.5895321350872977e-07 6.798730687661121 0.3314098842718224 LVKPGNQNTQVTEAWNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVKPGNQNTQVTEAWNK 17 1 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 42998300.0 1858300.0 27601000.0 13539000.0 False True 2436249.2958027986 23483038.387855325 12138114.155258525 1.0 9.63901289917752 4.982295603397494 21.216230337796787 -9.917949039664471 8.545017006827083 0.9999999964204769 7.310654251287507 0.7100319594843544 1.9010968751756983 1.4381078877445254e-07 1.2839764438196066e-08 1.8407291342705994 0.6135763780902032 1.207955568912272e-10 9.917949039664471 6.31065425486703 LVKPGNQNTQVTEAWNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVKPGNQNTQVTEAWNK 17 1 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 33958400.0 8880000.0 3860400.0 21218000.0 False True 8598109.260666242 5401877.851720056 15660369.273644214 1.0 0.6282634574594229 1.8213736065539063 23.03558801284146 -6.823020102235501 1.3589815967421195 0.8002302770724498 1.8490970972301566 0.8911385824901984 0.16446976053866177 0.18959014202422123 0.6872030910734154 0.09508840148699384 0.2189824134797934 1.503072391606013e-07 6.823020102235501 1.048866820157707 LVKPGNQNTQVTEAWNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVKPGNQNTQVTEAWNK 17 1 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 39670300.0 1858300.0 17452000.0 20360000.0 False True 2545363.7286692373 16680912.933953574 15551387.32736229 1.0 6.553449609606349 6.109691574607625 21.27944039931968 -10.184183872038021 5.783817542092064 0.9998980649519974 6.331570592107131 0.9948311637107546 0.181163459168339 0.0002381323358531086 3.358973657024762e-05 0.17541378112933048 0.05847025502495147 6.543590722042234e-11 10.184183872038021 5.331672527155133 LVLAGGPLGLMQAVLDHTIPYLHVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVLAGGPLGLMQAVLDHTIPYLHVR 25 0 A0A0S2Z4K7;A0A0A0MT83;P26440-2;P26440;H0YLC3;H7C4G6 A0A0S2Z4K7 IVD Isovaleryl-CoA dehydrogenase, mitochondrial 0 2089560000.0 712520000.0 734050000.0 642990000.0 False True 1080944932.1894712 603053042.3411722 515902744.6674711 1.0 0.5578943241074072 0.4772701451335748 30.009645882071975 -13.999999999999998 0.2393359050352905 3.9169288045277595 0.4413969714694718 0.9995238671487324 0.005013980733223962 13.600052343648128 0.15484222808119752 18.952648858679034 0.03955032438565028 1.0000000000000041e-14 13.999999999999998 -3.475531833058288 LVLAGGPLGLMQAVLDHTIPYLHVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVLAGGPLGLMQAVLDHTIPYLHVR 25 0 A0A0S2Z4K7;A0A0A0MT83;P26440-2;P26440;H0YLC3;H7C4G6 A0A0S2Z4K7 IVD Isovaleryl-CoA dehydrogenase, mitochondrial 0 1330820000.0 712520000.0 125570000.0 492730000.0 False True 922371185.8689702 118581919.1150987 403058195.83674115 1.0 0.12856203763930693 0.43698047164929393 29.780772204164425 -10.449946300853462 6.03186026813223 1.0003449932784687 0.2827712549116378 0.878206726145879 0.12591129843211943 0.0005844230187586696 5.329415957671341e-05 0.12196891051418525 0.040637696827245814 3.548572635054286e-11 10.449946300853462 -0.7175737383668309 LVLDAFALPLTNLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVLDAFALPLTNLFK 15 0 P55060-3;P55060;P55060-4;P55060-2 P55060-3 CSE1L Exportin-2 0 64370000.0 19751000.0 0.0 44619000.0 False True 16423831.617657825 0.0 53948626.60505338 1.0 0.0 3.284777137330814 23.96928740587838 -6.8250130659781725 1.34994244316678 0.463548518223505 3.3645550738812875 0.8955423126861282 0.4443249382278678 0.18705067458690386 0.6683624231788132 0.25854572235667356 0.5952927357165153 1.4961906417339977e-07 6.8250130659781725 2.9010065556577826 LVLEFTFTKPVLSVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVLEFTFTKPVLSVR 15 1 Q9Y484-2;Q9Y484-3;Q9Y484;A0A0U1RR06;H0Y329;A0A0U1RQR1;C9J0A8;C9JYH8;G8JLI5;C9J471;C9JBX7;C9JUS5;C9J7Q8;C9J5L0;A0A0U1RQS7;C9JE01;C9JVT3 Q9Y484-2 WDR45 WD repeat domain phosphoinositide-interacting protein 4 0 59839000.0 15706000.0 18904000.0 25229000.0 False True 23827150.262403633 15530433.502373844 20242477.091736495 1.0 0.651795675577662 0.8495551028473883 24.506103079099137 -10.16820722287252 5.267617001383993 1.0000103561748743 0.7506753892124148 0.6794163590107634 0.08073494810636427 9.81964007067428e-06 1.5506012945157919e-06 0.07817452321188989 0.026057092456016773 6.788796290654544e-11 10.16820722287252 -0.2493349669624595 LVLEFTFTKPVLSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVLEFTFTKPVLSVR 15 1 Q9Y484-2;Q9Y484-3;Q9Y484;A0A0U1RR06;H0Y329;A0A0U1RQR1;C9J0A8;C9JYH8;G8JLI5;C9J471;C9JBX7;C9JUS5;C9J7Q8;C9J5L0;A0A0U1RQS7;C9JE01;C9JVT3 Q9Y484-2 WDR45 WD repeat domain phosphoinositide-interacting protein 4 0 49125000.0 15706000.0 20805000.0 12614000.0 False True 20331726.611545004 19647183.460935183 10318381.430569798 1.0 0.9663312829407653 0.5075014841440318 24.277229401191587 -6.9216430814971615 0.812468411026533 1.0095373012159792 0.4306459706260587 0.9946247306281419 0.016470572281097662 0.0972150934662331 0.10068239293504824 0.01431584421995686 0.043578709354472785 1.197724459087794e-07 6.9216430814971615 -0.5788913305899205 LVLEVAQHLGESTVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVLEVAQHLGESTVR 15 0 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 0 61176000.0 17094000.0 24792000.0 19290000.0 False True 22410399.538531475 21093130.238459077 17294055.84274591 1.0 0.9412206240318232 0.7716977920456642 24.417665034037967 -6.952333986996722 0.5326125275064607 1.0026244788827618 0.7025638966415875 0.9993718963170536 0.002425746202895592 0.0825620028585597 0.03218784864080038 0.0026959718336423554 0.014023492612367005 1.1160046727293354e-07 6.952333986996722 -0.3000605822411744 LVLEVAQHLGESTVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVLEVAQHLGESTVR 15 0 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 0 96948000.0 38097000.0 27458000.0 31393000.0 False True 36887631.58824353 38422122.59157838 23170231.53018727 1.0 1.041599065520485 0.6281300949007489 25.136633826364726 -6.882132012341007 1.067880046568003 1.026584353097781 0.5976080437124112 0.975363105923757 0.029176551760058945 0.1257563573875688 0.26103908794382286 0.021005363635491225 0.051081121424825536 1.3118010906930292e-07 6.882132012341007 -0.4289763093853698 LVLEVAQHLGESTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVLEVAQHLGESTVR 15 0 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 0 267959000.0 33445000.0 184300000.0 50214000.0 False True 50738510.15701576 151410225.05752754 40289180.89042192 1.0 2.9841283196722244 0.794055260309038 25.59657782215022 -6.668157008573355 1.9440684778956019 2.2684618750070165 0.8030027014228484 0.27087880117881424 0.8431735584901233 0.46533819217774797 3.3888665405034346 0.3494005759162502 0.9357047100832856 2.1470541187732687e-07 6.668157008573355 -1.465459173584168 LVLEVAQHLGESTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVLEVAQHLGESTVR 15 0 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 0 122028000.0 17094000.0 28019000.0 76915000.0 False True 23414113.747980386 26781027.933557495 58749261.11414883 1.0 1.1437984893136315 2.5091387932296314 24.480875095560858 -6.92705514506287 0.7705750379958788 0.9768140406703856 2.769518617523574 0.9959273232161007 0.04339973476754292 0.09419567289194179 0.08538245752220558 0.038867680965090634 0.12559915009965028 1.1828913471409703e-07 6.92705514506287 1.7927045768531886 up LVLEVAQHLGESTVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVLEVAQHLGESTVR 15 0 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 0 78965000.0 38097000.0 14345000.0 26523000.0 False True 31679343.483262148 14267720.637740426 32068836.67150386 1.0 0.45037930300793033 1.0122948630058417 24.917039101799002 -10.806476817720302 11.903411122616873 1.001335431835876 0.731337083006886 0.2335978270747665 0.22940106675419156 0.008159494116118608 0.00013265496968670502 0.22292226049987263 0.0740388759284333 1.5614323837124034e-11 10.806476817720302 -0.26999834882899 LVLEVAQHLGESTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVLEVAQHLGESTVR 15 0 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 0 135269000.0 33445000.0 56425000.0 45399000.0 False True 43295211.799511194 53284899.14843864 37136847.83307737 1.0 1.2307342298078383 0.8577587749206171 25.36770414424267 -6.739352935228994 1.6889582216148329 1.1373867714027992 0.8575657616612963 0.6020956985334163 0.09694621036781172 0.31898025831406046 1.7863592531459684 0.04541278988307685 0.11152277358812648 1.822414091149406e-07 6.739352935228994 -0.2798210097415029 LVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEK 37 0 Q09028-3;Q09028;Q09028-2;Q09028-4;E9PNS6;C9JPP3;E9PND5 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 50841900.0 27091700.0 7794200.0 15956000.0 False True 26231688.812746815 10906464.706216037 11776644.930260502 1.0 0.4157744011097081 0.4489472642927151 24.64480735642531 -9.962824198832264 5.317872103181221 1.0000015913640212 0.4323608326989514 0.9974451138232668 0.013542764692948833 2.780662205142375e-07 5.4233071197294765e-08 0.01311276547776677 0.004370908508526237 1.0893709783582405e-10 9.962824198832264 -0.5676407586650698 LVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEK 37 0 Q09028-3;Q09028;Q09028-2;Q09028-4;E9PNS6;C9JPP3;E9PND5 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 322343200.0 50233200.0 190080000.0 82030000.0 False True 76207436.93883704 156158738.89818126 65816734.5449737 1.0 2.0491272921763786 0.8636523833992376 26.183428458665563 -6.673058880903748 1.9259556580362611 1.6678381564228209 0.8682986651399182 0.2930254982400653 0.44532566713959637 0.45406006720541553 3.249753731221718 0.18593154222537864 0.4948931712064221 2.1229566156574903e-07 6.673058880903748 -0.7995394912829027 LVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVLGTHTSDEQNHLVIASVQLPNDDAQFDASHYDSEK 37 0 Q09028-3;Q09028;Q09028-2;Q09028-4;E9PNS6;C9JPP3;E9PND5 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 170239200.0 50233200.0 82716000.0 37290000.0 False True 65027867.644407414 78112781.88679221 30503602.62771105 1.0 1.2012201032630683 0.46908508202228355 25.954554780758013 -6.833426713818351 1.312457332235629 1.1072921264710884 0.44795846139510126 0.9125668125379298 0.09131816335629185 0.17662134418967326 0.5937764105754194 0.0546082581594973 0.12567773471231675 1.4674837004693762e-07 6.833426713818351 -0.6593336650759871 down LVLHTSSYDAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVLHTSSYDAKR 12 1 Q9ULW8 Q9ULW8 PADI3 Protein-arginine deiminase type-3 1 10015200000.0 2431100000.0 2967900000.0 4616200000.0 True False 3187195642.805887 2525100888.7835884 4138559905.7171345 1.0 0.7922641631627559 1.29849572148439 31.56964043420738 -6.7952930752691465 1.4752045029202323 0.8846903802578439 1.3046864155013707 0.8179965118930925 0.0886395767325068 0.22754859356105842 0.9780795348868593 0.0472826285293352 0.11028481076645798 1.6021638363813376e-07 6.7952930752691465 0.4199960352435268 LVLHTSSYDAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVLHTSSYDAKR 12 1 Q9ULW8 Q9ULW8 PADI3 Protein-arginine deiminase type-3 1 11289900000.0 3169700000.0 3167600000.0 4952600000.0 True False 3069079608.5060563 4432439198.815777 3655365485.184774 1.0 1.4442242509875352 1.1910298693633774 31.51515892217819 -10.117071927388064 4.530792131369429 0.9999682646315495 1.3176270601851992 0.6772413597404365 0.10336617348629706 12040117.27504495 26885087.415561143 2251.705696379609 0.03538498809761251 7.637092883866349e-11 10.117071927388064 0.3176587955536496 LVLIGHSIGSYFTLQMLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVLIGHSIGSYFTLQMLK 18 0 C9JUM0;A0A0A0MSH6;B5MDU6;Q9H6V9-3;Q9H6V9;Q9H6V9-2;C9JHU6;B4DRG3;B5MCU4;Q9H6V9-4 C9JUM0 LDAH;C2orf43;FLJ21820 UPF0554 protein C2orf43 0 26111900.0 9025500.0 7341700.0 9744700.0 False True 11683687.669202812 6933127.941127022 7971264.589065596 1.0 0.5934023689628529 0.6822558780030691 23.477992361579343 -9.990753506801015 5.741035073399047 1.000000581827184 0.6378291234828118 0.9568075359054647 0.03627429316793425 2.701500054549303e-07 4.7495626408424375e-08 0.03512248933145196 0.011707477777824311 1.0215191044012881e-10 9.990753506801015 -0.36217145834437214 LVLIGSNHSLPFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVLIGSNHSLPFLK 14 0 F1T0I1;O15027-2;O15027-4;O15027-3;O15027;O15027-5;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5;A0A0C4DH09 F1T0I1 SEC16A Protein transport protein Sec16A 0 15239700.0 3822100.0 5557200.0 5860400.0 False True 5010810.1132690525 4728087.42179594 5254022.024926285 1.0 0.9435774485398202 1.0485374432795183 22.256612436599607 -6.760696090308144 1.6099044162347511 0.9672549923924769 1.048933455753194 0.6937874061479641 0.023733829314036264 0.2817470323441571 1.4393775809194236 0.011631116849141643 0.027931621210018534 1.7350177001314595e-07 6.760696090308144 0.08167846336071705 LVLIGSNHSLPFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVLIGSNHSLPFLK 14 0 F1T0I1;O15027-2;O15027-4;O15027-3;O15027;O15027-5;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5;A0A0C4DH09 F1T0I1 SEC16A Protein transport protein Sec16A 0 24890000.0 9713200.0 7091800.0 8085000.0 False True 9404859.78273687 9923592.72324843 5967295.955199063 1.0 1.0551558399056329 0.6344906881176855 23.164975004060615 -6.87389799220192 1.1132052682061957 1.0320689895145296 0.6079512533936282 0.9684241048030573 0.033169848628188114 0.13317554988970104 0.3060838047815533 0.023064522158869404 0.05501000127491439 1.3369094951594686e-07 6.87389799220192 -0.4241177361209014 LVLIGSNHSLPFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVLIGSNHSLPFLK 14 0 F1T0I1;O15027-2;O15027-4;O15027-3;O15027;O15027-5;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5;A0A0C4DH09 F1T0I1 SEC16A Protein transport protein Sec16A 0 12526800.0 3340100.0 3666000.0 5520700.0 False True 5067175.894018486 3011773.657411266 4429531.225191227 1.0 0.5943692740104984 0.8741617259468015 22.27275047851299 -10.085825329768841 5.502038227453795 1.0000024809839794 0.7342654999785472 0.5460147495386618 0.11422479018805062 3.476257464037051e-06 5.778070612697027e-07 0.11059870909492933 0.036865892510143834 8.206815503949132e-11 10.085825329768841 -0.2657369810054322 LVLIGSNHSLPFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVLIGSNHSLPFLK 14 0 F1T0I1;O15027-2;O15027-4;O15027-3;O15027;O15027-5;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5;A0A0C4DH09 F1T0I1 SEC16A Protein transport protein Sec16A 0 19524000.0 3822100.0 5769600.0 9932300.0 False True 5235233.658368777 5514679.99448421 7586495.3021395095 1.0 1.0533780064751694 1.4491225792782194 22.319822498122498 -6.9315392925501955 0.7340406483096942 0.9943126790628958 1.5336479393263964 0.9968323754583844 0.011274669484754226 0.09184607526569562 0.07382021487007812 0.010367530436545484 0.0355097071477173 1.1707406754210764e-07 6.9315392925501955 0.5393352602635006 LVLIGSNHSLPFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVLIGSNHSLPFLK 14 0 F1T0I1;O15027-2;O15027-4;O15027-3;O15027;O15027-5;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5;A0A0C4DH09 F1T0I1 SEC16A Protein transport protein Sec16A 0 18436600.0 9713200.0 4660200.0 4063200.0 False True 8076956.167719807 4635094.577622721 4912796.3338858485 1.0 0.5738665013618921 0.608248482704441 22.94538027949489 -9.918246691178098 5.699592902044715 1.000000279324376 0.5910574927314544 0.9947264593796918 0.014036385107802994 4.982147022206257e-08 9.451471350999615e-09 0.013590680755605093 0.0045302238133393515 1.2071279585357931e-10 9.918246691178098 -0.4089427865929217 LVLIGSNHSLPFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVLIGSNHSLPFLK 14 0 F1T0I1;O15027-2;O15027-4;O15027-3;O15027;O15027-5;A0A3F2YNX0;A0A3F2YNZ0;X6RGP5;A0A0C4DH09 F1T0I1 SEC16A Protein transport protein Sec16A 0 19831800.0 3340100.0 10748000.0 5743700.0 False True 4323825.293214151 10149864.351748673 4698405.53533881 1.0 2.34742702663726 1.0866316783688112 22.04387680060544 -6.630543388230574 2.079052127216695 1.8873916195691942 1.0917742925971734 0.11923574228955025 0.5779040061581692 0.5576044524117832 4.5940472618250645 0.22732166987486446 0.6399525541346488 2.341297555934731e-07 6.630543388230574 -0.7956173269720208 LVLILNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVLILNK 7 0 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 14575100.0 4774400.0 5401400.0 4399300.0 False True 6259284.635355377 4595532.1744923005 3944102.637065426 1.0 0.7341944714471967 0.6301203518988869 22.577566352360837 -13.999999999993811 0.12962007818516877 2.263113350757545 0.4836660293882332 0.999647338783854 0.002924681645975549 11.937321341291227 0.11192244481417332 3.8428163456568414 0.1302282088686724 1.0000000000142503e-14 13.999999999993811 -1.7794473213693118 LVLILNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVLILNK 7 0 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 11029200.0 3884200.0 3445700.0 3699300.0 False True 3760898.1971035823 4821585.979088116 2730342.353378835 1.0 1.2820304423026956 0.7259814571640308 21.84264582424757 -6.768769116824347 1.5788128731112625 1.1620101308553554 0.7229697271191479 0.7260214331043097 0.11882580041197183 0.26839040448916857 1.3200578249262052 0.05932688813478281 0.14140293817438068 1.703063664370095e-07 6.768769116824347 -0.43904040373620756 LVLILNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVLILNK 7 0 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 16494000.0 4774400.0 5830800.0 5888800.0 False True 6539624.703308628 5573175.976122872 4497986.723642974 1.0 0.8522164847324044 0.6878050236380205 22.640776413883728 -6.969748778929549 0.26413053788702684 1.043891937334288 0.49122532257531043 0.9999803498619122 0.0005652175900868399 0.07638441249099391 0.00932206705791898 0.0033427166207914043 0.01541835490486671 1.0721393133430097e-07 6.969748778929549 -0.5526666147589776 LVLILNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVLILNK 7 0 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 8129300.0 3884200.0 1783000.0 2462100.0 False True 3229884.3992358074 1773394.625102211 2976913.726535822 1.0 0.5490582342581045 0.9216781031668383 21.623051099681845 -10.003804958231196 7.023944844188109 1.000000026633182 0.7353681687124713 0.40209189744954965 0.1521214244748602 6.34057805971713e-08 9.061771959366076e-09 0.14729095126173558 0.04909697863270679 9.912770277220365e-11 10.003804958231196 -0.26463185792071076 LVLK(ub)HYLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVLKHYLQR 9 1 H3BR29;H3BSM7;Q96GQ5 H3BR29 C16orf58 RUS1 family protein C16orf58 1 7402110.0 995210.0 1014800.0 5392100.0 True False 963617.6033004122 1420014.9321120908 3979747.250467393 1.0 1.4736290902620577 4.130006796094912 19.87810122330817 -6.937278964856899 0.6844069076678305 0.9683173189385601 4.792430540657416 0.9977853764177702 0.06482495797925122 0.08903015898136121 0.06042820686730518 0.06187009169584342 0.23150286960250896 1.1553698631389021e-07 6.937278964856899 3.8241132217188563 up LVLK(ub)HYLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVLKHYLQR 9 1 H3BR29;H3BSM7;Q96GQ5 H3BR29 C16orf58 RUS1 family protein C16orf58 1 11368810.0 995210.0 2582700.0 7790900.0 True False 827561.2102784286 2568786.482474189 9419941.168948427 1.0 3.1040440883036724 11.382772720556993 19.658506498742447 -6.945253070367092 0.6087333807920896 0.9082561984704367 14.008754663237095 0.9987741329392279 0.15691309535365378 0.08544973663054524 0.04429578976220575 0.15969038687232776 0.6977743168635278 1.1343496193112916e-07 6.945253070367092 13.100498464766659 LVLK(ub)NLNNSNLFSPVNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVLKNLNNSNLFSPVNR 17 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3;H0YEN4 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 18096800.0 6165200.0 7207900.0 4723700.0 True False 8082636.90388173 6132509.416174145 4234936.836929956 1.0 0.7587263276949847 0.5239548537552275 22.946394608282837 -6.971459810696704 0.22054978274381143 1.107517405942446 0.1685302335156902 0.9999916385203564 0.0005619590491469521 0.07583179442353105 0.007311441048980847 0.00647570582210588 0.02376764329519919 1.067923612860268e-07 6.971459810696704 -0.9389871724267558 LVLK(ub)NLNNSNLFSPVNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVLKNLNNSNLFSPVNR 17 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3;H0YEN4 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 28885900.0 8282900.0 10174000.0 10429000.0 True False 8019963.873330243 14236531.256709082 7697332.036706371 1.0 1.7751365818556295 0.9597714102308168 22.93516430726563 -6.65760937278115 1.9812216693280074 1.4999197167571194 0.9631722177248385 0.2255580609857174 0.330224037727163 0.490134144855594 3.6957900674208704 0.13477528802407046 0.3660154130666446 2.1998376324635533e-07 6.65760937278115 -0.5367474990322809 LVLK(ub)NLNNSNLFSPVNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVLKNLNNSNLFSPVNR 17 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3;H0YEN4 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 22153200.0 6165200.0 5944000.0 10044000.0 True False 8444641.048265398 5681374.425820539 7671814.062673213 1.0 0.6727786762455158 0.9084831455623646 23.00960466980573 -10.050620438802627 6.208994285116016 1.0000002668211758 0.7906309109039358 0.5126777489913934 0.09622594665331141 3.554233618595673e-07 5.433555042620309e-08 0.0931704916118838 0.03105679073844088 8.899785943941234e-11 10.050620438802627 -0.20936935591724004 LVLK(ub)NLNNSNLFSPVNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVLKNLNNSNLFSPVNR 17 1 P52948-6;P52948-2;P52948-5;P52948;A0A3B3ITD8;P52948-4;P52948-3;H0YEN4 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 1 27269300.0 8282900.0 10685000.0 8301400.0 True False 6887598.344686249 10627437.784193553 10037184.358663121 1.0 1.5429816392229916 1.4572836359435453 22.715569582699906 -10.672415411077827 6.513638458563349 0.9963244900079004 1.5001326375832644 0.9784537065136201 0.034986063335000483 0.0018754192733226372 9.431861533891334e-05 0.034020515675532395 0.011291703387151217 2.126104413032554e-11 10.672415411077827 0.5038081475753641 LVLLELNFLPTTGTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVLLELNFLPTTGTK 15 0 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 783030000.0 273810000.0 271160000.0 238060000.0 False True 415389788.1923306 222769379.41724983 191007336.65459514 1.0 0.5362899757037476 0.4598267508833327 28.629890508970984 -13.999999999999998 0.2536362328767379 4.284922306702726 0.43012828245632156 0.9995496416403021 0.005064920255888023 14.14508003796956 0.15936064277813516 23.725119417393127 0.0345880206862731 1.0000000000000041e-14 13.999999999999998 -3.8547940242464045 LVLLELNFLPTTGTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVLLELNFLPTTGTK 15 0 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 614740000.0 273810000.0 147370000.0 193560000.0 False True 354452442.60200834 139168729.95135877 158334066.09331602 1.0 0.39263019018780554 0.44670045135250785 28.401016831063433 -10.580669995875965 9.981622906421602 1.000037851626405 0.41966532203188 0.9935315112619548 0.022074091685424346 1.859509703674886e-05 7.811872897649252e-07 0.021374525215240088 0.007124382456692019 2.6262133466406453e-11 10.580669995875965 -0.580372529594525 LVLLELNFLPTTGTKLTK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVLLELNFLPTTGTKLTK 18 1 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 160376000.0 61862000.0 74825000.0 23689000.0 True False 93849176.71799403 61471894.13960667 19006858.766742453 1.0 0.6550072817827974 0.2025255780757233 26.48384075343309 -7.388079430450544 0.41193249407671434 1.030799593888098 8.866342190802765e-24 0.9991441338238473 0.009553335485565603 0.11108772011206657 0.041071216383818304 0.0150477840366786 0.0593150183763848 4.091858146942836e-08 7.388079430450544 -1.030799593888098 down LVLLELNFLPTTGTKLTK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVLLELNFLPTTGTKLTK 18 1 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 140612000.0 61862000.0 64517000.0 14233000.0 True False 80081578.48232509 60926572.23499901 11642740.042912623 1.0 0.7608063351104672 0.14538599592517157 26.25496707552554 -7.164347199325397 0.592245780557862 1.002727895536323 5.048709793414476e-28 0.9984012146174488 0.014394043928081501 0.08322457271346693 0.04898761802148894 0.014365521794806598 0.05013512624431002 6.849404277829336e-08 7.164347199325397 -1.002727895536323 down LVLLFSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVLLFSGK 8 0 Q15126 Q15126 PMVK Phosphomevalonate kinase 0 16908700.0 4788600.0 6414700.0 5705400.0 False True 6277900.97286837 5457651.764304765 5115059.938061301 1.0 0.8693433980388457 0.814772319628392 22.58185084146203 -13.999999999999991 0.11968862209425975 1.6228747516034825 0.7273070518913509 0.9996944660567283 0.0013584325026898695 11.964985842406726 0.10643254744984725 1.7734441980060855 0.0776142390120074 1.0000000000000205e-14 13.999999999999991 -0.8955676997121316 LVLLFSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVLLFSGK 8 0 Q15126 Q15126 PMVK Phosphomevalonate kinase 0 11471400.0 4802400.0 2784200.0 3884800.0 False True 4649950.44070085 3895945.579411197 2867254.33849812 1.0 0.8378466887109428 0.6166204081233093 22.148783909343525 -6.966785014356835 0.32596604024091114 1.0282521316364506 0.41901620382853394 0.9999453521889053 0.001161572000021588 0.07736033746948749 0.012751470473236088 0.0032760877504540305 0.019359896447962575 1.0794809576079374e-07 6.966785014356835 -0.6092359278079167 LVLLFSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVLLFSGK 8 0 Q15126 Q15126 PMVK Phosphomevalonate kinase 0 30331400.0 7978400.0 11580000.0 10773000.0 False True 12103816.099169822 9513458.52504703 8643711.828026354 1.0 0.785988356655513 0.7141311266798914 23.528958637279416 -13.999999999999998 0.15243644628762762 2.038911229375328 0.6372463751914382 0.9995583098594505 0.0025518089139920275 11.96772880921272 0.12308206102183628 3.6804195333894323 0.06946885874140583 1.0000000000000041e-14 13.999999999999998 -1.40166485418389 LVLLFSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVLLFSGK 8 0 Q15126 Q15126 PMVK Phosphomevalonate kinase 0 22626500.0 4788600.0 7209900.0 10628000.0 False True 6559074.827049197 6891342.778049034 8117885.290530769 1.0 1.050657746673294 1.2376570636232322 22.64506090298492 -6.946721356641905 0.5937545080692144 0.9978613964221805 1.2999237456459452 0.9989181747492804 0.0033616861023247208 0.08482972499851954 0.041622253323803836 0.003471839012117476 0.015683779697093163 1.1305210243701271e-07 6.946721356641905 0.3020623492237646 LVLLFSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVLLFSGK 8 0 Q15126 Q15126 PMVK Phosphomevalonate kinase 0 12193200.0 4802400.0 3624700.0 3766100.0 False True 3993408.382392782 3605173.0216533793 4553574.097521048 1.0 0.9027809521182057 1.1402725845916677 21.9291891847778 -6.795581703397669 1.4741440227054239 0.9460556962520036 1.143194732024555 0.8188481622509869 0.04149157304321002 0.2271308160854272 0.9748782791997859 0.022148740290667396 0.05164869186396175 1.6010994067379466e-07 6.795581703397669 0.19713903577255143 LVLLFSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVLLFSGK 8 0 Q15126 Q15126 PMVK Phosphomevalonate kinase 0 36533400.0 7978400.0 16418000.0 12137000.0 False True 10328196.077776056 15504323.867418103 9928190.53613649 1.0 1.5011647484869022 0.9612705317920631 23.300084959371866 -6.662927668489478 1.9630530803426598 1.3218213193700799 0.9635329378046963 0.2479440082981783 0.21323764862967604 0.4775074373962128 3.5405303270690442 0.08767907867611127 0.23638607915317225 2.1730630712028742e-07 6.662927668489478 -0.35828838156538356 LVLSK(ub)LYEEGSNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVLSKLYEEGSNK 13 1 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 32893000.0 10288000.0 10515000.0 12090000.0 True False 13487667.62913372 8946202.987148983 10839042.775469042 1.0 0.6632876219328646 0.8036261771498893 23.685137554320907 -10.111583846245582 5.120107294045907 1.0000075332332252 0.7334569000739009 0.8278746080359549 0.05729297525519822 4.92690325429746e-06 8.549063956256573e-07 0.05547525161388634 0.018491228251263533 7.734213452257469e-11 10.111583846245582 -0.26655063315932437 LVLSK(ub)LYEEGSNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVLSKLYEEGSNK 13 1 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 48040000.0 12950000.0 18236000.0 16854000.0 True False 12538909.338471625 25517729.89948369 12439431.790837953 1.0 2.035083691146144 0.9920664911956532 23.57990852906527 -6.647891823613382 2.015767526933011 1.672764892803206 0.9964179127890065 0.18569714823722383 0.44201076668122813 0.5136880753447078 3.9982888712733193 0.1779713440731261 0.4896289019438141 2.2496148821316558e-07 6.647891823613382 -0.6763469800141995 LVLSK(ub)LYEEGSNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVLSKLYEEGSNK 13 1 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 34210800.0 10288000.0 14939000.0 8983800.0 True False 14091751.622746121 14278945.58333329 6862011.467168826 1.0 1.0132839384058552 0.48695234282248834 23.748347615843798 -6.901109822806041 0.9542156612015735 1.0212215642091838 0.43044082833071945 0.9871106775544565 0.0278201334909389 0.11059328188334434 0.17284433076895517 0.02181971132569749 0.057094484324890726 1.2557123835704972e-07 6.901109822806041 -0.5907807358784642 down LVLSK(ub)LYEEGSNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVLSKLYEEGSNK 13 1 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 39541800.0 12950000.0 18611000.0 7980800.0 True False 10768498.782272743 18510738.849005744 9649548.380950049 1.0 1.7189711605371016 0.8960903999762041 23.360313804499548 -6.675780687653148 1.916490237296619 1.4565963791269896 0.8992847618504277 0.3051250055223975 0.3049990484866058 0.44794396614831444 3.177062182315957 0.1278618709043908 0.339109128362909 2.1096932451438193e-07 6.675780687653148 -0.5573116172765619 LVLSK(ub)LYEEGSNKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVLSKLYEEGSNKR 14 2 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 60607000.0 16402000.0 25370000.0 18835000.0 True False 21503180.83719395 21584894.89148546 16886134.878077693 1.0 1.0038000914799623 0.7852854424620671 24.35804674907831 -6.902943089886226 0.9424678697046169 1.0083660538410042 0.7609263748417957 0.9879746751277957 0.011199018006128263 0.10927145375185901 0.16545111700707832 0.008860221406266253 0.023412720064287018 1.25042287537059e-07 6.902943089886226 -0.2474396789992085 LVLSK(ub)LYEEGSNKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVLSKLYEEGSNKR 14 2 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 135316000.0 34710000.0 52152000.0 48454000.0 True False 33608150.04929343 72976565.56908715 35762443.81115837 1.0 2.171394898619878 1.0641003375284035 25.00230779632 -6.632906773512513 2.0696283142093312 1.7700799831107403 1.0685778902766954 0.12814581223221566 0.5020947793248902 0.5514801423808495 4.505220816993846 0.19814930144861784 0.556222890103551 2.32859106384791e-07 6.632906773512513 -0.701502092834045 LVLSK(ub)LYEEGSNKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVLSKLYEEGSNKR 14 2 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 164363000.0 58561000.0 65988000.0 39814000.0 True False 88841318.38256827 54211925.83340278 31944745.44890385 1.0 0.6102107310019367 0.3595708171657636 26.404727466482747 -8.465426557275247 0.17657809611291508 1.3563427436518642 6.348084308935983e-07 0.9998231598807408 0.0035040940681232264 0.14080777568382016 0.0432542412376507 0.1526628967797876 0.1334796648173858 3.424312906432664e-09 8.465426557275247 -1.3563421088434333 down LVLSK(ub)LYEEGSNKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVLSKLYEEGSNKR 14 2 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 65955000.0 16402000.0 32518000.0 17035000.0 True False 22466262.647383552 31081247.237353977 13011683.846837735 1.0 1.383463183226594 0.5791654825308957 24.4212568106012 -6.77707638652139 1.5473886528754186 1.2179555141653355 0.5733841748962978 0.7568443542670871 0.1619718694531251 0.2551555299085566 1.2065410619869459 0.08246321100245892 0.19504921624993335 1.6707967179360506e-07 6.77707638652139 -0.6445713392690378 LVLSK(ub)LYEEGSNKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVLSKLYEEGSNKR 14 2 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 97830000.0 34710000.0 48032000.0 15088000.0 True False 28862902.91372098 47773242.082394436 18242831.0409701 1.0 1.6551780056635874 0.6320511521485851 24.782713071754277 -6.7337733138639795 1.7097672328774793 1.3926216185018958 0.6322605222832989 0.5765573114211937 0.27534817913135795 0.32920020210687195 1.8870370847317908 0.12754235788928586 0.315109050245685 1.8459787024024528e-07 6.7337733138639795 -0.7603610962185969 LVLSK(ub)LYEEGSNKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVLSKLYEEGSNKR 14 2 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 141472000.0 58561000.0 71544000.0 11367000.0 True False 75808368.90988702 67562513.50776957 9298322.635269295 1.0 0.891227637255733 0.12265562191850031 26.175853788575196 -6.99066606613013 0.7711669022389865 1.0071574463403032 6.573978174180706e-26 0.9968124596866244 0.022045805258105195 0.08110213906268274 0.07684764719639549 0.02039801340218249 0.05962779601672691 1.021724797340517e-07 6.99066606613013 -1.0071574463403032 down LVLSLEPLEHPLISSPSFFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVLSLEPLEHPLISSPSFFSK 21 0 Q5UIP0-2;Q5UIP0;H7BZN3 Q5UIP0-2 RIF1 Telomere-associated protein RIF1 0 12991700.0 2766400.0 4675100.0 5550200.0 False True 4196831.050930429 3840791.8782769763 4453200.537260921 1.0 0.915164759235538 1.061086444324142 22.0008689560908 -6.74907752999392 1.6532180516337966 0.9500627064613849 1.0613575613818271 0.6450793671269242 0.03564664467426253 0.3016209449232946 1.621654093146807 0.017035122188016776 0.04139745629906093 1.7820606066450148e-07 6.74907752999392 0.11129485492044222 LVLVGDGGTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVLVGDGGTGK 11 0 B5MDF5;P62826;J3KQE5;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 68128100.0 9206100.0 30977000.0 27945000.0 False True 12069286.251999212 26355352.347400285 25053519.46736831 1.0 2.183671163075999 2.075807876643768 23.52483702537919 -10.104333083673273 5.080909186846678 0.9999682184290516 2.12973951986258 0.9932096391926241 0.04403500229914756 1.5853721596612323e-05 2.794511698152656e-06 0.042637900472219784 0.014212235878222275 7.864423935893584e-11 10.104333083673273 1.1297713014335282 LVLVGDGGTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVLVGDGGTGK 11 0 B5MDF5;P62826;J3KQE5;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 31747140.0 12063340.0 4188800.0 15495000.0 False True 11680395.874838475 5861409.684303424 11436394.659964068 1.0 0.5018160126687042 0.9791101930543273 23.477585835431846 -10.733693739249453 10.03578633065809 1.000551577290036 0.7404631028615158 0.2827652317525001 0.19485453319078128 0.0024094724151267283 6.393684294795298e-05 0.18903736926558462 0.06288903016507638 1.846316967123788e-11 10.733693739249453 -0.2600884744285201 LVLVGDGGTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVLVGDGGTGK 11 0 B5MDF5;P62826;J3KQE5;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 66453110.0 9206100.0 28252010.0 28995000.0 False True 12609843.95549796 27003742.78129647 22146978.170769587 1.0 2.1414811219390777 1.75632452304165 23.58804708690208 -10.096062664338184 4.551264399222253 0.9999401948658895 1.9489028222892002 0.8900248399533891 0.15723952335631783 24528968.022367727 27206300.03727597 14625.683257985253 0.05382727451817547 8.015623976280943e-11 10.096062664338184 0.9489626274233107 LVLVGDGGTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVLVGDGGTGK 11 0 B5MDF5;P62826;J3KQE5;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 17470240.0 12063340.0 3375400.0 2031500.0 False True 10031201.706574675 3357216.050235555 2456277.257405275 1.0 0.3346773545621319 0.24486370918006523 23.257991110866122 -13.999999999999998 0.28220086576141223 6.488629017978897 0.21840729074198686 0.9996100582074198 0.006650909464194773 15.518590268566138 0.1683158189678251 49.22231907942552 0.035160689361266546 1.0000000000000041e-14 13.999999999999998 -6.27022172723691 LVLVLGDLHIPHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVLVLGDLHIPHR 13 0 F8VXU5;Q9UBQ0;Q9UBQ0-2 F8VXU5 VPS29 Vacuolar protein sorting-associated protein 29 0 18581900.0 6747500.0 8762200.0 3072200.0 False True 8846037.842882944 7454913.914788093 2754318.2146233222 1.0 0.8427404502667739 0.31136179423416116 23.076599983347172 -6.948750068092133 0.5724001139884032 1.0065495850375934 0.12161063617862194 0.9990995196839599 0.008841566964804284 0.08399154144456646 0.03806952040002833 0.00934165964654134 0.04430071788387519 1.1252523585682285e-07 6.948750068092133 -0.8849389488589714 down LVLVLGDLHIPHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVLVLGDLHIPHR 13 0 F8VXU5;Q9UBQ0;Q9UBQ0-2 F8VXU5 VPS29 Vacuolar protein sorting-associated protein 29 0 50801500.0 17268900.0 11704500.0 21828100.0 False True 16720708.222017957 16378167.88816117 16110665.781036569 1.0 0.9795140056683886 0.963515753466825 23.995132619689798 -6.9738961984798955 0.13599873530139242 1.0226999240676173 0.9199138624893791 0.9999989027448478 1.4536866917439825e-05 0.07505726309689202 0.004103905877207881 0.000943281762761327 0.0021224559130302123 1.0619493453277252e-07 6.9738961984798955 -0.10278606157823822 LVLVLGDLHIPHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVLVLGDLHIPHR 13 0 F8VXU5;Q9UBQ0;Q9UBQ0-2 F8VXU5 VPS29 Vacuolar protein sorting-associated protein 29 0 209454800.0 48714000.0 92592000.0 68148800.0 False True 73902699.47043996 76068234.17540202 54679159.80931992 1.0 1.0293025115520746 0.7398804130448688 26.139123727385233 -6.881963920832839 1.068836373645241 1.0186766751694565 0.7185850921983853 0.9752332315649375 0.02047120336067829 0.1259023945505438 0.26192180580009633 0.01472733885333085 0.0357974493550476 1.3123089150165367e-07 6.881963920832839 -0.3000915829710712 LVLVLGDLHIPHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVLVLGDLHIPHR 13 0 F8VXU5;Q9UBQ0;Q9UBQ0-2 F8VXU5 VPS29 Vacuolar protein sorting-associated protein 29 0 54302900.0 6747500.0 20757100.0 26798300.0 False True 9242233.094331201 19839982.68744945 20469093.468312975 1.0 2.146665474128592 2.214734605738072 23.139810044870064 -10.838590465853907 0.5141647356963975 1.0122321570787557e-14 2.211008886037183 0.999768820075104 0.008473228228166391 2.489801969583813 0.24882578612256717 3.0507174292836226 0.013480899059610016 1.4501386712316785e-11 10.838590465853907 2.2110088860371726 LVLVLGDLHIPHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVLVLGDLHIPHR 13 0 F8VXU5;Q9UBQ0;Q9UBQ0-2 F8VXU5 VPS29 Vacuolar protein sorting-associated protein 29 0 32175800.0 17268900.0 6489700.0 8417200.0 False True 14359855.491983758 6454738.697995408 10177197.603264416 1.0 0.4494988617119928 0.7087256281197072 23.775537895124074 -10.422408118298746 6.086412432087791 1.000128441060134 0.5791122449158546 0.7785106193508677 0.10582888422842486 0.00018450255066490836 1.7509052223881223e-05 0.10249931225248186 0.034156125513700134 3.7808711900686824e-11 10.422408118298746 -0.42101619614427954 LVLVLGDLHIPHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVLVLGDLHIPHR 13 0 F8VXU5;Q9UBQ0;Q9UBQ0-2 F8VXU5 VPS29 Vacuolar protein sorting-associated protein 29 0 122906500.0 48714000.0 45340000.0 28852500.0 False True 63061233.296498336 42816789.14293681 23601641.051650167 1.0 0.6789716423975226 0.37426545308242043 25.910250049477682 -7.232181947319463 0.2410154919747224 1.1233523778375356 2.5663815653656968e-11 0.9999655920375381 0.0014986147667846257 0.09560544039666122 0.013067826872692027 0.01319169398315221 0.04124213594091034 5.8589265383925185e-08 7.232181947319463 -1.1233523778118717 down LVLVNAVYFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVLVNAVYFR 10 0 A0A2R8YD12;A0A024QZX5;A0A087X1N8;P35237;A0A2R8Y6A7 A0A2R8YD12 SERPINB6 Serpin B6 0 34869000.0 10036000.0 14245000.0 10588000.0 False True 12991799.839135718 13452253.22763863 8661092.642054297 1.0 1.0354418474887421 0.6666584114053344 23.631097974837505 -6.883324869958465 1.0611151248535122 1.0231005429113145 0.6388012553070653 0.9762685517566805 0.02559139076285 0.12472421967637602 0.25485198023921 0.01851955518228966 0.04518708773960668 1.3082029678013287e-07 6.883324869958465 -0.38429928760424914 LVLYPSAQEK(ub)VLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVLYPSAQEKVLQR 14 1 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 1 21983900.0 6751600.0 8247800.0 6984500.0 True False 8851412.982587414 7017260.389672588 6261810.940054878 1.0 0.7927842033217759 0.7074363101544549 23.077476345452727 -13.999999999999998 0.12185749683832693 1.986427244045587 0.5745638163085302 0.9996838764262707 0.0021841446471645197 11.956984386096964 0.10766792824157946 2.849559535193624 0.11792955221706532 1.0000000000000041e-14 13.999999999999998 -1.4118634277370568 LVLYPSAQEK(ub)VLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVLYPSAQEKVLQR 14 1 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 1 33004700.0 7562000.0 9887700.0 15555000.0 True False 7321948.449229518 13835910.173674311 11480678.86000265 1.0 1.8896486733842344 1.567981383590696 22.803796185591224 -10.11555959164923 5.550584291660659 0.9999910162801261 1.7288150284876178 0.8725267199739319 0.13132012115689426 1.4599397791019073e-05 2.326349130135951e-06 0.12715172766620833 0.04238338685513788 7.663733751451641e-11 10.11555959164923 0.7288240122074917 LVLYPSAQEK(ub)VLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVLYPSAQEKVLQR 14 1 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 1 88580000.0 16178000.0 27820000.0 44582000.0 True False 24543208.770225737 22855303.64134789 35770348.15901522 1.0 0.931227202413504 1.4574438287144238 24.548820542970457 -6.874015227043756 1.1125961336261505 0.9599768708230085 1.4907133359809848 0.9685307538730866 0.04142984764407103 0.13306528559594694 0.3054252258993254 0.028821888132560276 0.06875667887976657 1.3365486542387832e-07 6.874015227043756 0.5307364651579762 LVLYPSAQEK(ub)VLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVLYPSAQEKVLQR 14 1 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 1 29703200.0 6751600.0 8166600.0 14785000.0 True False 9247848.97512955 7805772.608665214 11293087.506633164 1.0 0.8440635903178626 1.2211582971352495 23.140686406975618 -6.794429628435978 1.478809078359999 0.9133462341364332 1.2256601914787921 0.8152917688718347 0.0664924773655284 0.22881212734703554 0.9883946046571381 0.03538480218638929 0.08257733616337497 1.6053523627241573e-07 6.794429628435978 0.3123139573423589 LVLYPSAQEK(ub)VLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVLYPSAQEKVLQR 14 1 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 1 24355300.0 7562000.0 10038000.0 6755300.0 True False 6288138.053401262 9983923.301613005 8167801.997021838 1.0 1.587739203055933 1.2989221813608027 22.5842014610255 -10.06621271522573 4.521505983970723 0.9999742019105654 1.443330692231495 0.7585465247108443 0.1179090554470501 18266349.02122251 20333155.34705095 3893.2033513896304 0.04036340626976257 8.585928840782601e-11 10.06621271522573 0.4433564903209296 LVLYPSAQEK(ub)VLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVLYPSAQEKVLQR 14 1 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 1 72942000.0 16178000.0 27015000.0 29749000.0 True False 20942739.916055944 25511591.501906447 24334987.25051694 1.0 1.2181592095477323 1.1619772459600808 24.319946865062906 -10.072845865229898 4.328187396886849 0.9999820510164922 1.1900682277423045 0.9385006335487602 0.022936190674224623 15922646.83984758 0.1293270640385345 2927.8650190605867 0.0078516681221631 8.455788949849796e-11 10.072845865229898 0.1900861767258123 LVNACLAEELPHIHAFEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVNACLAEELPHIHAFEQK 19 0 A0A087WZT3;Q9H3K6 A0A087WZT3 BOLA2 BolA-like protein 2 0 46627000.0 7978000.0 23134000.0 15515000.0 False True 10459235.259061899 19682497.375625703 13909656.63038895 1.0 1.881829492129719 1.3298923186891318 23.318274035080123 -10.070512731505865 5.43755079668527 0.9999946514175841 1.6058609054098136 0.616357136573812 0.22532740750194027 1.4610060867836762e-05 2.4977017416762987e-06 0.21817425104064073 0.07272410805806144 8.501337708313193e-11 10.070512731505865 0.6058662539922295 LVNACLAEELPHIHAFEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVNACLAEELPHIHAFEQK 19 0 A0A087WZT3;Q9H3K6 A0A087WZT3 BOLA2 BolA-like protein 2 0 34875300.0 15987000.0 9203500.0 9684800.0 False True 15479501.435841372 12878505.545618448 7148060.342227805 1.0 0.8319715979869639 0.4617758764295292 23.883855670085183 -6.958109535422069 0.4613073214204251 1.010650822580381 0.26814064834818746 0.9996935230728162 0.003936094417231702 0.08038350362566705 0.023679982609771447 0.005038941219189939 0.03057760720930216 1.101261520244752e-07 6.958109535422069 -0.7425101742321936 down LVNACLAEELPHIHAFEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVNACLAEELPHIHAFEQK 19 0 A0A087WZT3;Q9H3K6 A0A087WZT3 BOLA2 BolA-like protein 2 0 193740000.0 18940000.0 143450000.0 31350000.0 False True 28733364.699473094 117850226.7200345 25153658.75880689 1.0 4.101511533809182 0.8754164025652086 24.77622360769163 -6.655112975950314 1.9901839135905703 3.004364987783206 0.8889284289889501 0.21508664442208303 1.3221065842971143 0.4961204312326725 3.772137900229125 0.5376813700919417 1.4650035240032582 2.2125190772394583e-07 6.655112975950314 -2.115436558794256 LVNACLAEELPHIHAFEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVNACLAEELPHIHAFEQK 19 0 A0A087WZT3;Q9H3K6 A0A087WZT3 BOLA2 BolA-like protein 2 0 49909000.0 7978000.0 15448000.0 26483000.0 False True 10927682.197343366 14765456.280295348 20228260.834505662 1.0 1.3511974464159457 1.8511025914922163 23.381484096603014 -6.96611331772896 0.3384006569427344 0.944763665384732 2.274109432143436 0.9999342894838273 0.0028308794175526657 0.07758516933849957 0.013538906948633035 0.0070919013102284665 0.043320035435887375 1.0811518163449387e-07 6.96611331772896 1.3293457667587039 LVNACLAEELPHIHAFEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVNACLAEELPHIHAFEQK 19 0 A0A087WZT3;Q9H3K6 A0A087WZT3 BOLA2 BolA-like protein 2 0 36584000.0 15987000.0 5520000.0 15077000.0 False True 13293898.844184885 5490262.6643657815 18229530.991828363 1.0 0.41299115697479316 1.3712704756891134 23.66426094551946 -6.740955270733928 1.6833929952386497 0.651120259610342 1.3719303718006097 0.6091741743165162 0.24663011146409092 0.3160739117422239 1.7590991654246622 0.11589013182783303 0.2840649609963825 1.8157026577005934e-07 6.740955270733928 0.7208101121902677 LVNACLAEELPHIHAFEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVNACLAEELPHIHAFEQK 19 0 A0A087WZT3;Q9H3K6 A0A087WZT3 BOLA2 BolA-like protein 2 0 61230000.0 18940000.0 23139000.0 19151000.0 False True 24518203.363215465 21851294.3091843 15665714.505853966 1.0 0.8912273866676417 0.6389421881277466 24.54734992978408 -6.957048110771848 0.47521536115722757 1.0063367833918402 0.5133990643184364 0.9996445540449761 0.0028512263024016897 0.08077298891389184 0.025159424772592937 0.00352335712661672 0.020815742632158962 1.1039563177897534e-07 6.957048110771848 -0.4929377190734038 LVNACLAEELPHIHAFEQK(ub)TLTPDQWAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVNACLAEELPHIHAFEQKTLTPDQWAR 28 1 A0A087WZT3;Q9H3K6 A0A087WZT3 BOLA2 BolA-like protein 2 1 154709000.0 17294000.0 36155000.0 101260000.0 True False 26236262.36075436 29702857.76969568 81245916.61616528 1.0 1.1321299261790752 3.09670316217364 24.645058871298634 -6.920532852545858 0.8207644603883857 0.9574798784657861 3.4174246487323297 0.9943276584946225 0.07220976228563543 0.09785933977272863 0.10399693432688596 0.062392207986175854 0.18785720491341587 1.2007902348621886e-07 6.920532852545858 2.4599447702665436 up LVNACLAEELPHIHAFEQK(ub)TLTPDQWAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVNACLAEELPHIHAFEQKTLTPDQWAR 28 1 A0A087WZT3;Q9H3K6 A0A087WZT3 BOLA2 BolA-like protein 2 1 187561400.0 17294000.0 50530400.0 119737000.0 True False 22387423.91570476 47718338.82020852 97946094.60536993 1.0 2.131479664649319 4.375049803593562 24.416185193391083 -6.96021278046972 0.4324244396364855 0.9131400243882576 5.679771976948624 0.9997780101240699 0.020897339668265503 0.07962519802231244 0.020851097445556275 0.029326219715840103 0.18618332226025586 1.0959411135636794e-07 6.96021278046972 4.766631952560366 LVNHFVEEFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVNHFVEEFK 10 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 8265000.0 1430800.0 3936200.0 2898000.0 False True 1875792.6558869102 3348934.303187425 2598142.75957893 1.0 1.7853435413968957 1.3850905916626906 20.839068935100823 -10.380441143815707 5.533137133590144 0.9997816204011318 1.5852170665297909 0.7402857539439847 0.1634025824821239 0.00044035569676966076 4.9307669751101354e-05 0.15827167228216843 0.052737956723376805 4.1644615455557514e-11 10.380441143815707 0.585435446128659 LVNHFVEEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVNHFVEEFK 10 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 7895100.0 3142100.0 1806900.0 2946100.0 False True 3042355.755398584 2528404.592859021 2174428.0288944873 1.0 0.8310680262728743 0.7147185285731359 21.536757432623304 -7.154950996900481 0.06472483759493793 1.5638007053088208 5.825347058571182e-07 0.9999999245839153 3.164196457244025e-05 0.08471589148318487 0.0024461105174399707 0.024491792162683514 0.03416961456861677 6.99920966293781e-08 7.154950996900481 -1.563800122774115 LVNHFVEEFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVNHFVEEFK 10 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 9639300.0 1430800.0 4950000.0 3258500.0 False True 1959805.425916131 4731292.632538971 2488909.4109140434 1.0 2.4141644726426246 1.2699778141243678 20.902278996623714 -6.59354492226574 2.2155191403282304 1.9549966355494341 1.273454008385348 0.0024393302650781434 0.6122510999348542 0.6591524891765943 6.10499502816777 0.2302403960503865 0.681809272789706 2.5495003606257044e-07 6.59354492226574 -0.6815426271640861 LVNHFVEEFK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVNHFVEEFKR 11 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 50415700.0 4299800.0 8139900.0 37976000.0 True False 6523110.957486511 6687271.247671023 30470026.954527926 1.0 1.0251659509173467 4.671088251159943 22.63712873815722 -6.908412091586692 0.9064625221413568 0.8813675861238031 5.126630541638541 0.9903088385915382 0.16978254838381646 0.10547794152957213 0.14452553809178692 0.13792098346153747 0.3766714798377127 1.234775228882597e-07 6.908412091586692 4.245262955514738 up LVNHFVEEFK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVNHFVEEFKR 11 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 150242500.0 4299800.0 24375700.0 121567000.0 True False 5566175.861729353 23019170.86703759 99443053.38275544 1.0 4.135545020290785 17.865596749553568 22.40825506024967 -6.942801939140268 0.6329631614457116 0.8501737202990086 21.894706714409043 0.9985083136627386 0.28287761109910137 0.08651140091817576 0.04896157458835918 0.2816010363961437 1.1679155730546982 1.1407699193325913e-07 6.942801939140268 21.044532994110035 LVNILVQLPLSGNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVNILVQLPLSGNR 14 0 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 0 29071900.0 7552900.0 10412000.0 11107000.0 False True 11458301.490953043 8553897.250672694 8911696.581628954 1.0 0.7465240164457589 0.7777502266514131 23.449889867801254 -9.980209238926124 6.959334481934595 1.0000000190222578 0.7621371216501024 0.9872394593421662 0.012748046934125143 3.759585713512785e-09 5.550103143453428e-10 0.012343244287775808 0.004114414456044542 1.0466241730464824e-10 9.980209238926124 -0.23786289737215538 LVNILVQLPLSGNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVNILVQLPLSGNR 14 0 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 0 1869350.0 0.0 1004800.0 864550.0 False True 0.0 960404.613570739 660361.0959661617 0.0 LVNILVQLPLSGNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVNILVQLPLSGNR 14 0 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 0 3749870.0 1262400.0 761470.0 1726000.0 False True 1049741.5338024015 757367.8099700387 2086898.6198776783 1.0 0.721480274507841 1.9880118607086632 20.001602722164364 -6.849056365018202 1.239635188765631 0.8514847494534331 2.0377295862801117 0.9389239004252569 0.13430093875841556 0.1584952626030795 0.46916490658422233 0.08479597264995063 0.19610846894385003 1.415610042729889e-07 6.849056365018202 1.1862448368266785 LVNILVQLPLSGNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVNILVQLPLSGNR 14 0 Q9NR09;A0A3B3IUB9 Q9NR09 BIRC6 Baculoviral IAP repeat-containing protein 6 0 20414800.0 7552900.0 6919500.0 5942400.0 False True 9777377.939917125 6534423.742270655 4860944.174172976 1.0 0.6683206665862036 0.4971623480286759 23.221016189893703 -13.999999999997508 0.08427179641028656 2.7457411085091605 0.024112946851669266 0.9998684575191279 0.002394074958515666 12.216906905975225 0.08289415748179095 3.90320475361965 0.4274664626028254 1.0000000000057386e-14 13.999999999997508 -2.7216281616574913 LVNK(ub)CALDFFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVNKCALDFFR 11 1 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 48837800.0 3417800.0 11419000.0 34001000.0 True False 5185052.47464938 9381190.232945783 27280687.446832273 1.0 1.8092758518476038 5.2614100976243305 22.30592715904413 -6.943399589884373 0.6271385614678127 0.9623342674328994 6.293492756803242 0.998576144081377 0.0697277390938152 0.08624936523295922 0.047799905748110806 0.0697707627378489 0.2929613051708825 1.1392011379634181e-07 6.943399589884373 5.331158489370343 LVNK(ub)CALDFFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVNKCALDFFR 11 1 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 7260500.0 1416100.0 1056200.0 4788200.0 True False 1177549.8938669057 1050510.0409607159 5789390.4818646 1.0 0.8921150996931356 4.916471490522638 20.167356758766793 -6.900742473021445 0.9565861062522452 0.8360736295134361 5.345287031523106 0.9869314125721228 0.21402478284286056 0.11086003075025684 0.17436386215719116 0.16757170140546973 0.4376279778338203 1.2567749824246477e-07 6.900742473021445 4.50921340200967 up LVNK(ub)CALDFFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVNKCALDFFR 11 1 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 39835800.0 3417800.0 13789000.0 22629000.0 True False 4424409.474910133 13021630.028494842 18510754.19314759 1.0 2.943134016491395 4.183779620335338 22.07705348113658 -8.355554447010793 0.23719012026196745 4.1272064850021195e-14 5.298337857681948 0.9994990289404799 0.02932711287858494 0.11352686444874613 0.05788657608940286 0.5074230639148938 0.4860839682320734 4.410070710950092e-09 8.355554447010793 5.298337857681907 LVNK(ub)VIELLPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVNKVIELLPEK 12 1 Q9H2M9 Q9H2M9 RAB3GAP2 Rab3 GTPase-activating protein non-catalytic subunit 1 13434100.0 2667000.0 4164400.0 6602700.0 True False 3496462.827264737 3543087.752704059 5919515.941570681 1.0 1.0133348837790437 1.6930012512678376 21.737464736543885 -6.9111455709356715 0.8878999799516856 0.9797108609978407 1.783022699800019 0.9913466523318915 0.03010112134829969 0.10366537892323771 0.13469530943602048 0.024784614989167224 0.06897192188251189 1.2270278754023246e-07 6.9111455709356715 0.8033118388021783 LVNK(ub)VIELLPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVNKVIELLPEK 12 1 Q9H2M9 Q9H2M9 RAB3GAP2 Rab3 GTPase-activating protein non-catalytic subunit 1 5027000.0 2667000.0 0.0 2360000.0 True False 3653061.9729649965 0.0 1802616.6057256847 1.0 0.0 0.4934536066089775 21.800674798066776 -10.12796219399253 5.53530164595541 1.0000112191546788 0.24672680330434515 0.7565174506514167 0.2014515913218543 2.7892162920670176e-05 4.394098292583307e-06 0.19505756703059512 0.06501822152130278 7.447968067999356e-11 10.12796219399253 -0.7532844158503337 LVNK(ub)VIELLPEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVNKVIELLPEK 12 1 Q9H2M9 Q9H2M9 RAB3GAP2 Rab3 GTPase-activating protein non-catalytic subunit 1 8611400.0 2154800.0 4790600.0 1666000.0 True False 1791811.673825583 4764792.086940356 2014352.8972863343 1.0 2.6592036186299377 1.1241990030043825 20.77298758199 -6.627764692994697 2.089034507349968 2.0949007571599587 1.1303687224121954 0.10939808307638232 0.7121171465324032 0.5647982921983822 4.694313168563303 0.2791221291193991 0.7887671075601094 2.3563256292569888e-07 6.627764692994697 -0.9645320347477633 LVNK(ub)VIELLPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVNKVIELLPEK 12 1 Q9H2M9 Q9H2M9 RAB3GAP2 Rab3 GTPase-activating protein non-catalytic subunit 1 16261500.0 7143700.0 5375000.0 3742800.0 True False 9247660.47337923 5075876.524995273 3061648.804371062 1.0 0.5488822323880662 0.33107279545831886 23.140656999779114 -10.989968817747926 0.13877441602860477 1.9961542079717418 7.671511026173944e-14 0.9997190546620065 0.004669228322911662 3.202705745050729 0.08101890492553275 1.2450091506234642 0.22562312201870344 1.0233664671391809e-11 10.989968817747926 -1.9961542079716652 LVNLQHLDLLNNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVNLQHLDLLNNK 13 0 Q96AG4 Q96AG4 LRRC59 Leucine-rich repeat-containing protein 59 0 15073500.0 4129200.0 7538000.0 3406300.0 False True 5413421.18722968 6413359.782893871 3053848.7515368275 1.0 1.1847147231076454 0.5641254663023247 22.368109209563734 -6.826942091936274 1.3414765531527466 1.0989273195840294 0.5484401276209914 0.899628750411895 0.08242834945731088 0.18461373368233117 0.6508023958700002 0.04825904999844546 0.11108397833205931 1.4895596797424728e-07 6.826942091936274 -0.5504871919630381 LVNLQHLDLLNNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVNLQHLDLLNNK 13 0 Q96AG4 Q96AG4 LRRC59 Leucine-rich repeat-containing protein 59 0 13521200.0 5513200.0 1737000.0 6271000.0 False True 5338186.483773109 2430593.158335337 4628436.974032565 1.0 0.45532188988222794 0.8670429532767311 22.347918274675788 -9.806515276797843 6.256876198378902 1.0000000115472818 0.6611824215792934 0.47450053764095024 0.16808442027945794 2.7079001806964766e-08 5.232502592308105e-09 0.16274704618730887 0.05424901337483788 1.5612941167235932e-10 9.806515276797843 -0.3388175899679884 LVNLQHLDLLNNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVNLQHLDLLNNK 13 0 Q96AG4 Q96AG4 LRRC59 Leucine-rich repeat-containing protein 59 0 18939200.0 4129200.0 6023000.0 8787000.0 False True 5655876.827434221 5756883.944602477 6711691.5739456015 1.0 1.0178587901133762 1.1866756965763607 22.431319271086625 -6.927129532154379 0.7699791788869683 0.9971411843025404 1.2189297273043787 0.9959436168864246 0.005356750495339404 0.09415568690329082 0.08518148228881785 0.0047993969651093935 0.01552305590972528 1.1826887557767125e-07 6.927129532154379 0.22178854300183826 LVNTGLLTLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVNTGLLTLR 10 0 E9PCB6;Q9BYT8;H0YAK4;H0YAF7 E9PCB6 NLN Neurolysin, mitochondrial 0 13288600.0 4349200.0 5507200.0 3432200.0 False True 5701843.317712717 4685547.226897463 3077068.8679871648 1.0 0.8217600810499053 0.539662122673256 22.442996964989973 -6.9643501305070625 0.3690358530755354 1.0219320449799325 0.32968561039643335 0.9998991150285325 0.0019035564505482244 0.07818218961480264 0.015641764343635695 0.0037238019000050294 0.02397087522381182 1.0855500945117992e-07 6.9643501305070625 -0.6922464345834991 LVNTGLLTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVNTGLLTLR 10 0 E9PCB6;Q9BYT8;H0YAK4;H0YAF7 E9PCB6 NLN Neurolysin, mitochondrial 0 18862300.0 7555800.0 4340400.0 6966100.0 False True 7315945.264835819 6073544.354886979 5141469.431479545 1.0 0.8301790315572131 0.7027758198509332 22.802612850746872 -6.974293920293338 0.11646825567508547 1.2419945738339493 0.2876947421926025 0.9999995116910055 8.488341353683057e-05 0.07493245923398882 0.003458899274417801 0.009354603716179433 0.018743426518869937 1.0609772696978173e-07 6.974293920293338 -0.9542998316413468 LVNTGLLTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVNTGLLTLR 10 0 E9PCB6;Q9BYT8;H0YAK4;H0YAF7 E9PCB6 NLN Neurolysin, mitochondrial 0 20099500.0 4349200.0 6558900.0 9191400.0 False True 5957216.772710681 6269106.11061816 7020580.622825029 1.0 1.0523548747354987 1.178500110149675 22.506207026512865 -6.95624749268178 0.48543761981066524 0.9971217846145752 1.2390411394739282 0.9996047139470091 0.0014895169873972445 0.08106982044406072 0.02629896898650246 0.0017986906140153355 0.010404465532331342 1.1059933286634053e-07 6.95624749268178 0.241919354859353 LVNTGLLTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVNTGLLTLR 10 0 E9PCB6;Q9BYT8;H0YAK4;H0YAF7 E9PCB6 NLN Neurolysin, mitochondrial 0 13719600.0 7555800.0 3808000.0 2355800.0 False True 6282982.478694699 3787485.548171179 2848386.8880114914 1.0 0.6028165064942272 0.45334948771069133 22.58301812618115 -13.999999999999998 0.1356007335514372 2.8912243461737313 0.2581922916303318 0.9996210404877346 0.004490628633010267 11.932092740766791 0.1150310405819782 5.987676402342073 0.17400378349501414 1.0000000000000041e-14 13.999999999999998 -2.6330320545433996 LVNTGLLTLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVNTGLLTLR 10 0 E9PCB6;Q9BYT8;H0YAK4;H0YAF7 E9PCB6 NLN Neurolysin, mitochondrial 0 10690400.0 2445800.0 5361400.0 2883200.0 False True 3166136.3139256793 5063033.376950629 2358487.1841302384 1.0 1.5991204657493079 0.7449101839857173 21.594291939515333 -6.718218256293323 1.7660324776360594 1.3651999207435048 0.7464022369282404 0.5039358343681974 0.2521694619512067 0.35880177168350424 2.186088701110644 0.1134265397431148 0.2853085685041088 1.9132941503391782e-07 6.718218256293323 -0.6187976838152645 LVPGGGATEIELAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVPGGGATEIELAK 14 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 25195000.0 4003900.0 8260100.0 12931000.0 False True 5249151.673822752 7027725.27761761 11593024.162910681 1.0 1.3388306748049428 2.2085519495892054 22.323652854034325 -6.954893774652645 0.5022542395151454 0.982917383696513 2.602121166865399 0.9995314684445374 0.011017816618698613 0.08157814393087923 0.02827517339316005 0.012866932825483617 0.07175019323658025 1.109446144729812e-07 6.954893774652645 1.6192037831688861 up LVPGGGATEIELAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVPGGGATEIELAK 14 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 19533100.0 7080200.0 2800800.0 9652100.0 False True 6855442.926505541 3919174.045979047 7123925.453206777 1.0 0.5716879402242777 1.0391634106766738 22.70881845009594 -6.665738291196269 1.9526175285151968 0.7256118487253024 1.0372369748772885 0.26024344658961196 0.18211879921514468 0.47098250121471447 3.45778513367186 0.075200066493083 0.20202883112572362 2.1590450724399913e-07 6.665738291196269 0.3116251261519861 LVPGGGATEIELAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVPGGGATEIELAK 14 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 65453200.0 1388700.0 59259000.0 4805500.0 False True 2106759.4275690787 48683768.457319744 3855690.8186745243 1.0 23.108366252094747 1.830152398142336 21.00659415046157 -10.516861332672264 6.974373902210904 0.9951119538731075 12.469259313801416 0.27921784394658733 8.686794430002156 0.6576680119269432 0.04555876037279491 8.362573710385906 2.803650846610235 3.041856114980045e-11 10.516861332672264 11.474147359928308 LVPGGGATEIELAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVPGGGATEIELAK 14 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 26183900.0 4003900.0 12108000.0 10072000.0 False True 5484250.0313290395 11573028.524198348 7693201.039351318 1.0 2.1102299235240682 1.4027808716603984 22.386862915557217 -10.102749680971888 4.823279690185183 0.9999644283122625 1.7565053975986928 0.6039067600450366 0.2888148660358882 0.00011048587712583192 2.055329923441631e-05 0.2796568939948822 0.09321459718800992 7.893149325543579e-11 10.102749680971888 0.7565409692864303 LVPGGGATEIELAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVPGGGATEIELAK 14 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 10348500.0 7080200.0 1640000.0 1628300.0 False True 5887500.006042274 1631164.9944854868 1968770.0015914391 1.0 0.2770556251059772 0.33439830141331855 22.489223725530216 -10.735777077760597 10.5436430112828 1.0011367321140288 0.3057269668850241 0.9949097362027035 0.02341004957309496 0.0006260846456256685 1.5689578701696476e-05 0.022686509707537897 0.007555561010873991 1.8374812757332172e-11 10.735777077760597 -0.6954097652290047 LVPGGGATEIELAK(ub)QITSYGETCPGLEQYAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVPGGGATEIELAKQITSYGETCPGLEQYAIK 32 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 101059300.0 73120000.0 5530300.0 22409000.0 True False 70798845.62386452 7738577.6301335115 16539410.644410111 1.0 0.10930372609811354 0.2336113039509092 26.077222501549425 -10.717524751858683 6.84950538483692 1.0096271790554698 0.17145751502451412 0.9833981570010464 0.05074835615010739 0.007377125779685482 0.00030423406282251766 0.04858617377060753 0.01637896151806405 1.9163518404826686e-11 10.717524751858683 -0.8381696640309557 LVPGGGATEIELAK(ub)QITSYGETCPGLEQYAIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVPGGGATEIELAKQITSYGETCPGLEQYAIK 32 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 284560000.0 109140000.0 92048000.0 83372000.0 True False 165573359.20277148 75621315.22569342 66893487.65675428 1.0 0.4567239294401392 0.40401117654943713 27.302895320595887 -13.999999999999993 0.3298618655079139 6.909002556570322 0.39466068078724137 0.9997145550756473 0.0045513416929801424 18.81158558401154 0.18365022569966705 77.11180976823515 0.016900634704630744 1.0000000000000164e-14 13.999999999999993 -6.514341875783081 LVPGGGATEIELAK(ub)QITSYGETCPGLEQYAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVPGGGATEIELAKQITSYGETCPGLEQYAIK 32 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 115742000.0 73120000.0 17300000.0 25322000.0 True False 60802519.765234224 17206801.466218878 30616713.124300417 1.0 0.28299487476269714 0.5035434919887398 25.8576277769837 -10.230448115994763 4.993867285885869 1.000087087265671 0.3932691833756678 0.9098345299637842 0.09003859594850143 8.731420957087053e-05 1.3455127814907872e-05 0.08719191964572805 0.0290598318851128 5.882363849798739e-11 10.230448115994763 -0.6068179038900032 LVPGGGATEIELAK(ub)QITSYGETCPGLEQYAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVPGGGATEIELAKQITSYGETCPGLEQYAIK 32 1 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 247662000.0 109140000.0 73706000.0 64816000.0 True False 141283881.4710314 69604196.3072188 53020153.06832182 1.0 0.4926548986516224 0.375273899020059 27.074021642688336 -13.999999999999998 0.20565087036390942 3.8829788251350736 0.303149710919096 0.9994880357707652 0.006134090405618722 12.648383961445 0.14376489176312582 14.7039618513967 0.0717114505826485 1.0000000000000041e-14 13.999999999999998 -3.5798291142159777 LVPGGGATEIELAK(ub)QITSYGETCPGLEQYAIKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVPGGGATEIELAKQITSYGETCPGLEQYAIKK 33 2 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 1 197569000.0 55715000.0 65881000.0 75973000.0 True False 72124165.80684002 62214664.43594659 62146693.54880911 1.0 0.8626049776792892 0.8616625627982698 26.10397939175413 LVPGWTKPITIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVPGWTKPITIGR 13 1 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 51940000.0 11954000.0 14049000.0 25937000.0 False True 15671809.762700683 11952943.962573092 23253288.045272175 1.0 0.762703487571768 1.4837653338937031 23.901668454418566 -6.8180212987231785 1.3802932898984248 0.8718368012366565 1.4988652454245912 0.8798050834367146 0.10402466633087781 0.1960596791700919 0.7344857766360802 0.05922966891675472 0.13660012976193825 1.5204729606828168e-07 6.8180212987231785 0.6270284441879347 LVPGWTKPITIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVPGWTKPITIGR 13 1 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 45251000.0 19909000.0 5163000.0 20179000.0 False True 19276999.69263562 7224612.8246893175 14893514.54297611 1.0 0.374778904387768 0.7726054251412304 24.200377189566325 -9.923190842325344 5.432713437625652 1.0000006021819514 0.5736921647628379 0.6049117476225262 0.16241199700498915 1.1846077243815154e-06 2.3464277603782248e-07 0.15725496250581714 0.05241824663448644 1.1934635447058293e-10 9.923190842325344 -0.4263084374191135 LVPGWTKPITIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVPGWTKPITIGR 13 1 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 41695000.0 11954000.0 15368000.0 14373000.0 False True 16373716.844703272 14688990.94482 10978393.421226816 1.0 0.8971079128910023 0.6704887793865943 23.964878515941457 -6.958116238053033 0.4612234939181279 1.0065254573727822 0.5519171371189449 0.999693799978318 0.0024086217635421905 0.08038114536923419 0.023671294572533565 0.0030841928252089324 0.018718546892940804 1.1012445241904308e-07 6.958116238053033 -0.45460832025383735 LVPGWTKPITIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVPGWTKPITIGR 13 1 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 34942500.0 19909000.0 6872500.0 8161000.0 False True 16555215.618244614 6835476.478415557 9867427.36779939 1.0 0.4128896074831273 0.5960313411397088 23.9807824650006 -10.291469702097517 5.318382581989152 1.0000844973532648 0.5044604743113849 0.9070769536295691 0.0747672996780191 7.492205175042296e-05 9.981237622879474e-06 0.07240539240119244 0.024131042207803242 5.111287359224578e-11 10.291469702097517 -0.4956240230418799 LVPGWTKPITIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVPGWTKPITIGR 13 1 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 26005400.0 9562200.0 6776100.0 9667100.0 False True 12378456.399141444 6399004.078329375 7907786.992822364 1.0 0.5169468528219078 0.6388346606262506 23.56132808505219 -10.105657257949161 7.613337378171871 1.0000000655377956 0.5778907567241025 0.9411443301251345 0.04976048916451086 5.534309156751062e-08 6.506756216039865e-09 0.04818039363769462 0.016060128819440432 7.840481637842807e-11 10.105657257949161 -0.42210930881369313 LVPLK(ub)ETIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVPLKETIK 9 1 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 1 4409900.0 1062700.0 1331600.0 2015600.0 True False 1393209.991201439 1132930.4705361463 1807045.0470004466 1.0 0.8131799783887282 1.2970371002307668 20.40998129347477 -6.802069800553833 1.447890228929033 0.8971919706137995 1.304028114172187 0.8380158913722531 0.08018651819013839 0.21782514700319344 0.9013723126962475 0.043568252264964545 0.10117846973924365 1.5773577336858075e-07 6.802069800553833 0.4068361435583875 LVPLK(ub)ETIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVPLKETIK 9 1 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 1 6589700.0 2479400.0 1706900.0 2403400.0 True False 2400692.8041549437 2388474.07136591 1773877.439545504 1.0 0.9949103305646244 0.7389023020668894 21.195019375526147 -6.911200633467191 0.8875214627019308 1.0076286845212266 0.704953906877193 0.9913667659297812 0.011326426137574359 0.10362933137583627 0.13450121975061202 0.00932850175089662 0.02597012687317028 1.2268723151062188e-07 6.911200633467191 -0.3026747776440336 LVPLK(ub)ETIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVPLKETIK 9 1 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 1 22073500.0 4846000.0 3851500.0 13376000.0 True False 7351736.290055269 3164169.7330931486 10732227.737090938 1.0 0.43039761061252113 1.4598221853534759 22.80965358678723 -6.756497546855913 1.6255860021321409 0.6677076178120405 1.4629545522991652 0.6765355871743093 0.23947146902444785 0.2888410403033223 1.503477497035883 0.11627689154748547 0.2804142034329246 1.7518723297593682e-07 6.756497546855913 0.7952469344871247 LVPLK(ub)ETIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVPLKETIK 9 1 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 1 5834300.0 1062700.0 1662400.0 3109200.0 True False 1455608.9083876654 1588949.6711783395 2374870.9959840295 1.0 1.091604799903548 1.6315309574565624 20.473191354997663 -6.936212977819447 0.693899930358735 0.9933637891248375 1.7622255315104052 0.997624624777643 0.013580118707868157 0.08953746859401787 0.06280016957208406 0.012866804810374567 0.047297330903477985 1.1582092315739773e-07 6.936212977819447 0.7688617423855677 LVPLK(ub)ETIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVPLKETIK 9 1 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 1 7777600.0 2479400.0 3422400.0 1875800.0 True False 2061730.956043785 3403962.851906791 2268021.107280737 1.0 1.6510218474085427 1.100056775415934 20.975424650960424 -10.14087967790584 4.271893854391604 0.9999289604590039 1.3755393114079182 0.3825037701997267 0.22493054891912628 32631300.70399857 38731097.616931885 19615.42518239838 0.07699971157298452 7.22970076062526e-11 10.14087967790584 0.37561035094891426 LVPLK(ub)ETIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVPLKETIK 9 1 P06576 P06576 ATP5B ATP synthase subunit beta, mitochondrial 1 17479900.0 4846000.0 4848300.0 7785600.0 True False 6273242.528940987 4578487.843001779 6368700.687002079 1.0 0.7298439079757201 1.015216717291051 22.58077990887968 -11.055813063687792 11.741500058817392 1.5764159786557175 0.8725303126333542 0.21012807168925285 0.11650296154785378 0.04126238808413556 0.0001961405013542054 0.0026477664256910147 0.03760116915489005 8.794009618826101e-12 11.055813063687792 -0.7038856660223632 LVPLLDTGDIIIDGGNSEYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVPLLDTGDIIIDGGNSEYR 20 0 P52209-2;P52209;K7EM49;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 5454400.0 1938100.0 2470600.0 1045700.0 False True 2540867.8685870986 2101996.1103233723 937500.9950626944 1.0 0.8272748600234101 0.36896881048128294 21.276889922956077 -6.954174016629373 0.5109781427094074 1.0083673641969018 0.1677364662628336 0.9994894006644865 0.006016664789648658 0.08185185677978402 0.029352507817770237 0.006918375794789917 0.03782755732017717 1.1112863588445907e-07 6.954174016629373 -0.8406308979340682 down LVPLLDTGDIIIDGGNSEYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVPLLDTGDIIIDGGNSEYR 20 0 P52209-2;P52209;K7EM49;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 20299800.0 8119300.0 4241700.0 7938800.0 False True 7861557.265780121 5935432.930173289 5859390.121105042 1.0 0.7549945550875921 0.7453218138612135 22.90638368805329 LVPLLDTGDIIIDGGNSEYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVPLLDTGDIIIDGGNSEYR 20 0 P52209-2;P52209;K7EM49;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 8617200.0 1938100.0 1282400.0 5396700.0 False True 2654667.945183152 1225739.3276703 4122110.6085253395 1.0 0.46172981065085084 1.5527782357883353 21.340099984478968 -6.772555027741774 1.5645905088302121 0.6922657745550612 1.559527664915506 0.7402453891658406 0.2270193272603787 0.262328646212498 1.2676624656188609 0.11434360820114192 0.27156154943611843 1.6882819303859436e-07 6.772555027741774 0.8672618903604449 LVPVGYGIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVPVGYGIK 9 0 P24534 P24534 EEF1B2 Elongation factor 1-beta 0 18162700.0 2570500.0 7207400.0 8384800.0 False True 3369950.392757407 6132084.014225154 7517221.3286809595 1.0 1.8196362852711538 2.230662310292976 21.684295923743285 -9.693231475631272 0.17735646906890862 9.614887374731807e-17 2.710715429063666 0.9996047819678826 0.010169929253787487 1.1591830514397194 0.07521228439971199 0.8635576936260866 0.28206846673046737 2.026602268129701e-10 9.693231475631272 2.710715429063666 LVPVGYGIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVPVGYGIK 9 0 P24534 P24534 EEF1B2 Elongation factor 1-beta 0 12529800.0 4395700.0 2045600.0 6088500.0 False True 4256160.90958453 2862418.747663078 4493739.1989152115 1.0 0.6725353689558923 1.055819856057527 22.02112126411801 -6.680432803606294 1.9003692658638112 0.7929005485252529 1.0543691873624934 0.32627837834983153 0.1387719505290391 0.43745553170203505 3.054823524324879 0.05858771488154648 0.1544344363981161 2.0872150441444598e-07 6.680432803606294 0.2614686388372405 LVPVGYGIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVPVGYGIK 9 0 P24534 P24534 EEF1B2 Elongation factor 1-beta 0 17587100.0 2570500.0 8999500.0 6017100.0 False True 3520883.315150552 8601872.332633227 4595984.906064419 1.0 2.4431006547757215 1.305349963257131 21.747505985266177 -6.586573751116039 2.2417482035697107 1.97879441343668 1.3084868826626594 0.0 0.6258869666704987 0.6796936940577004 6.434263771239153 0.23352750602405434 0.6983044359709867 2.590754426689973e-07 6.586573751116039 -0.6703075307740205 LVPVLSAK(ub)AAQASDLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVPVLSAKAAQASDLEK 17 1 P37837 P37837 TALDO1 Transaldolase 1 53456900.0 22820800.0 20468100.0 10168000.0 True False 29918289.79694155 17414339.264028914 9115912.898343207 1.0 0.5820633258859979 0.30469364927654047 24.83452437379576 -8.298272817527387 0.21195592994974585 1.2669015251177003 3.736624424334643e-11 0.9997045534135293 0.0049122235657042546 0.09564524017594515 0.04755064017863616 0.11426493167001638 0.11517673602254595 5.031844162943169e-09 8.298272817527387 -1.266901525080334 down LVPVLSAK(ub)AAQASDLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVPVLSAKAAQASDLEK 17 1 P37837 P37837 TALDO1 Transaldolase 1 80391100.0 34864800.0 30553300.0 14973000.0 True False 33758036.008026645 42753392.02335465 11051122.119628374 1.0 1.2664656206062812 0.3273627090450626 25.00872763686145 -6.83088886663173 1.3237665788802218 1.1423069791609086 0.3016030439785667 0.9076533812290208 0.12008338010743975 0.17973163200871242 0.6156281849639319 0.07121370987341563 0.16389396428542966 1.4760842060983397e-07 6.83088886663173 -0.840703935182342 down LVPVLSAK(ub)AAQASDLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVPVLSAKAAQASDLEK 17 1 P37837 P37837 TALDO1 Transaldolase 1 138862500.0 44112000.0 33326000.0 61424500.0 True False 66921129.01917406 27378714.922773555 49283920.6516853 1.0 0.40911914254956877 0.7364478360424045 25.995958449346073 -10.174748855458521 5.566803615971761 1.0000108802023655 0.5727834892959791 0.6943072878900167 0.1336313795383565 1.804527874660759e-05 2.6749547912888266e-06 0.1293913193578428 0.04312934229021163 6.687305203822319e-11 10.174748855458521 -0.4272273909063864 LVPVLSAK(ub)AAQASDLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVPVLSAKAAQASDLEK 17 1 P37837 P37837 TALDO1 Transaldolase 1 50840300.0 22820800.0 19008000.0 9011500.0 True False 31258266.46893123 18168163.708949637 6883169.297668223 1.0 0.581227488319215 0.2202031678407267 24.89773443531865 -7.789349019508695 0.31746730950336766 1.0944894174619006 1.296996351759866e-10 0.9992508099879133 0.008721643554715133 0.11831707267577696 0.050535072328950166 0.039222211357291925 0.0813972271009044 1.6242429129666204e-08 7.789349019508695 -1.094489417332201 down LVPVLSAK(ub)AAQASDLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVPVLSAKAAQASDLEK 17 1 P37837 P37837 TALDO1 Transaldolase 1 83556700.0 34864800.0 38780400.0 9911500.0 True False 28991625.972523734 38571482.28789325 11983948.824401846 1.0 1.3304352892952138 0.41335897599394417 24.789132912295727 -6.8092489733905905 1.4177406809810968 1.180243101830006 0.3975967678923686 0.8578483754990066 0.14298250256328868 0.20782421171708412 0.8234484643783194 0.07930506843643251 0.18350765740210345 1.5514973088291412e-07 6.8092489733905905 -0.7826463339376373 down LVPVLSAK(ub)AAQASDLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVPVLSAKAAQASDLEK 17 1 P37837 P37837 TALDO1 Transaldolase 1 132131100.0 44112000.0 39006100.0 49013000.0 True False 57103853.57751638 36835376.24588242 40093136.915848814 1.0 0.6450593775756264 0.7021091293151321 25.767084771438522 -10.499466665545437 6.1769564707280304 1.000264239952262 0.6735842534453926 0.9776030362571048 0.023290463619041073 8.481999848990495e-05 6.873170973147762e-06 0.022568829824519437 0.007516964810166312 3.166163474307348e-11 10.499466665545437 -0.32667998650686947 LVPYGNHSYLESLTDKSK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVPYGNHSYLESLTDKSK 18 1 Q14457;K7ELY9;E7EV84 Q14457 BECN1 Beclin-1 1 16101100.0 3198200.0 4672200.0 8230700.0 True False 4140132.945946973 4412187.962806116 6732797.054113738 1.0 1.0657116620193259 1.626227259369746 21.981245664918067 -6.928921428768834 0.7555851852866107 0.9911269881431612 1.7382032032105226 0.9963222235355798 0.017041240351530464 0.09320123028612226 0.08044970542947663 0.015427082404757113 0.051020859931825424 1.177819041669921e-07 6.928921428768834 0.7470762150673613 LVQAFQFTDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVQAFQFTDK 10 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 316838000.0 114040000.0 119770000.0 83028000.0 False True 149507544.3649308 101900782.85980347 74437059.02081431 1.0 0.681576192644 0.4978816242150428 27.155643045818273 -10.525574000620349 0.09860098718488049 1.8975259716816886 1.448778036249004e-12 0.9999159067017035 0.001902211992333196 2.4359632246632925 0.053376255801492696 0.811890371190666 0.2947285734515452 2.98143948904224e-11 10.525574000620349 -1.8975259716802397 LVQAFQFTDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVQAFQFTDK 10 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 272477000.0 91888000.0 31909000.0 148680000.0 False True 88971065.73694827 44650430.10323673 109736247.69560865 1.0 0.5018533804602289 1.2333925280838456 26.40683289799002 -6.723371675863586 1.747336333503726 0.6980279353631024 1.2324623593856998 0.5283174062198939 0.20953978813082202 0.34880400719592364 2.083063128699637 0.09515543928826248 0.23791986999991574 1.890724814815108e-07 6.723371675863586 0.5344344240225974 LVQAFQFTDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVQAFQFTDK 10 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 464651000.0 55363000.0 355860000.0 53428000.0 False True 83989718.57745141 292354002.6531292 42867932.38167573 1.0 3.4808308398311154 0.5103949996230184 26.323709398470083 -6.685070645141065 1.8837521023965556 2.5623973893911054 0.5211483204946472 0.3476170409277908 1.0502795224947064 0.4273025583847544 2.935750169677312 0.4466667871274838 1.1705076298375132 2.0650442150792354e-07 6.685070645141065 -2.041249068896458 LVQAFQFTDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVQAFQFTDK 10 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 392300000.0 114040000.0 150990000.0 127270000.0 False True 156203669.81512114 144318762.54284045 97211447.20792726 1.0 0.9239140329651193 0.6223377934909234 27.218853107341165 -6.945085287393519 0.6104300636858451 1.0033337500111643 0.5272015381663122 0.9987568791316984 0.0057499818922605575 0.0855215390658977 0.044608461534869186 0.005842344268668578 0.02543349218100582 1.1347879424522554e-07 6.945085287393519 -0.4761322118448521 LVQAFQFTDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVQAFQFTDK 10 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 193552000.0 91888000.0 60720000.0 40944000.0 False True 76408943.32860829 60392889.30802371 49505201.096333526 1.0 0.7903903218278376 0.6478979938700222 26.187238173424298 -7.836122049133078 0.08012158874442436 1.5577839903876263 1.6203392391500344e-11 0.9999971431151938 0.00024436123693090097 0.12930549623693097 0.011000367379772892 0.09546894453814543 0.11226277347869972 1.458404349471953e-08 7.836122049133078 -1.5577839903714228 LVQAFQFTDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVQAFQFTDK 10 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 0 178983000.0 55363000.0 123620000.0 0.0 False True 71668494.8678827 116740438.32928638 0.0 1.0 1.6288947960256674 0.0 26.094835720562532 -6.816966709180502 1.484675423242051 1.3451400326965277 2.9201189565265877e-21 0.8374735626687386 0.27039850510332936 0.20920921477389662 0.923050296079955 0.14530321800980406 0.32031681293962466 1.5241695844546356e-07 6.816966709180502 -1.3451400326965277 LVQAFQFTDK(ub)HGEVCPAGWKPGSDTIKPDVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQK 32 3 Q06830;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 1 24292300.0 9759000.0 6213300.0 8320000.0 True False 9449205.886806522 8694303.091931447 6140742.405350174 1.0 0.9201093929036821 0.6498686216504396 23.17176165936628 -6.948726366113401 0.5726646297377901 1.003327102961181 0.5534519491002379 0.9990974354659414 0.00450088703539687 0.08400143506312413 0.038111702421626766 0.004754048145790586 0.02253126344338907 1.1253137718174963e-07 6.948726366113401 -0.4498751538609431 LVQAFQFTDK(ub)HGEVCPAGWKPGSDTIKPDVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQK 32 3 Q06830;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 1 155083000.0 28301000.0 11570000.0 115212000.0 True False 42934686.08024229 9505243.10317739 92440297.70078649 1.0 0.22138843836921676 2.153044685782056 25.355640307665183 -6.797295612878135 1.4669756768769004 0.5689286060972703 2.17795217393294 0.8241392814191163 0.33276792160932017 0.22463197533047968 0.9546381235595108 0.17848067197745388 0.4157741771635468 1.594793243717851e-07 6.797295612878135 1.6090235678356697 LVQAFQFTDK(ub)HGEVCPAGWKPGSDTIKPDVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQK 32 3 Q06830;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 1 20866700.0 9759000.0 9110200.0 1997500.0 True False 8115040.897003829 9061121.544366887 2415168.0146035105 1.0 1.1165835957416261 0.29761624682572085 22.952166934800555 -6.870822322110528 1.129796255410223 1.0662690893736615 0.24891036519379908 0.9654940103570477 0.06719433584377696 0.13606572846679155 0.3241133615736548 0.04613531669218228 0.109381084765641 1.3464110830199185e-07 6.870822322110528 -0.8173587241798624 down LVQAFQFTDK(ub)HGEVCPAGWKPGSDTIKPDVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVQAFQFTDKHGEVCPAGWKPGSDTIKPDVQK 32 3 Q06830;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 1 143552000.0 28301000.0 12400000.0 102851000.0 True False 36636202.39611202 11709929.099523952 84133173.34037852 1.0 0.3196272630256748 2.2964490814502945 25.126766629757633 -6.8137765794921705 1.3984997566217623 0.6308180767598616 2.3341352090396517 0.8694799563977288 0.29624381505438846 0.20169720560895893 0.7767197444341377 0.16652457357418907 0.3846075495486093 1.5354066615255015e-07 6.8137765794921705 1.70331713227979 up LVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSK 34 2 P32119 P32119 PRDX2 Peroxiredoxin-2 0 56153100.0 5166100.0 35160000.0 15827000.0 False True 6772807.128583559 29914265.052606557 14189373.863304272 1.0 4.416819272227337 2.095050633203516 22.69132248157394 -6.544348758968588 2.4112804275992006 3.3743886867359096 2.0970377161000413 0.0 1.4976606989996581 0.813145058490971 8.84390175318184 0.5343613143940769 1.6952910823771712 2.85529668444606e-07 6.544348758968588 -1.2773509706358683 LVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSK 34 2 P32119 P32119 PRDX2 Peroxiredoxin-2 0 26439300.0 8497900.0 4999400.0 12942000.0 False True 8228138.816015287 6995686.49152659 9552101.948322345 1.0 0.8502149329214225 1.1609067569120357 22.972134702939996 -6.775606499523309 1.5529508531759413 0.9147046423997139 1.1630390745698294 0.7515606880626662 0.06323493660343357 0.2574551789618489 1.2260242770915608 0.0320817745664437 0.07598343652647441 1.6764611764619365e-07 6.775606499523309 0.24833443217011542 LVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVQAFQYTDEHGEVCPAGWKPGSDTIKPNVDDSK 34 2 P32119 P32119 PRDX2 Peroxiredoxin-2 0 52230100.0 5166100.0 20854000.0 26210000.0 False True 7076146.778603097 19932601.325044 20019737.811894152 1.0 2.816872225618092 2.8291863408529028 22.754532543096833 -10.703631625613419 0.8825216142250831 2.8544374097551144e-07 2.826228474003507 0.9999932844749723 0.0022270673202308164 2.4064766263943183 0.4904321938646874 5.2248801893473535 0.001697217430983114 1.978647243577291e-11 10.703631625613419 2.826228188559766 LVQDVANNTNEEAGDGTTTATVLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVQDVANNTNEEAGDGTTTATVLAR 25 0 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 149245000.0 16444000.0 64781000.0 68020000.0 False True 21558243.24392253 55115927.31436019 60981942.89391266 1.0 2.556605688633645 2.8287065046964823 24.361736283556898 -10.294203685309851 0.38111919910432024 7.308916193730268e-24 2.8640167081221883 0.999093419685849 0.02425682414133615 1.6990622443361032 0.1769429252220803 1.819522643632754 0.07305391854727478 5.0792117025998307e-11 10.294203685309851 2.8640167081221883 LVQDVANNTNEEAGDGTTTATVLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVQDVANNTNEEAGDGTTTATVLAR 25 0 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 136579000.0 36307000.0 13921000.0 86351000.0 False True 35154454.158447 19479727.897055976 63733082.62552804 1.0 0.554118343276149 1.8129447363418698 25.067204158208945 -6.8109859044658805 1.4106251049770664 0.7572833225543493 1.8354166186950391 0.8623253846225385 0.19336858069760463 0.20546214948949568 0.8056412931794701 0.10778683747960904 0.24919554900607194 1.5453045933880579e-07 6.8109859044658805 1.07813329614069 LVQDVANNTNEEAGDGTTTATVLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVQDVANNTNEEAGDGTTTATVLAR 25 0 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 459876200.0 9186200.0 427590000.0 23100000.0 False True 13936137.001177387 351283223.7240818 18534274.874910317 1.0 25.206642536192334 1.3299435039526706 23.732327375949506 -4.296133672320417 12.616404920504312 9.999999999999975 13.615118238073578 0.0 11.363858747042256 0.0 0.0 3.4438383691490406 0.0 5.0566899723061086e-05 4.296133672320417 3.6151182380736024 LVQDVANNTNEEAGDGTTTATVLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVQDVANNTNEEAGDGTTTATVLAR 25 0 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 165080000.0 16444000.0 57853000.0 90783000.0 False True 22523791.182390876 55296863.165712565 69341925.13457407 1.0 2.4550424357043283 3.0786080626065147 24.42494634507979 -9.458866397303296 0.2514226110030106 2.085544906554902e-15 3.4608478778272094 0.999083026441317 0.026372978485888123 0.8631871397773034 0.09941935575159205 0.9649859892842847 0.27026881838514116 3.476430909875067e-10 9.458866397303296 3.460847877827207 LVQDVANNTNEEAGDGTTTATVLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVQDVANNTNEEAGDGTTTATVLAR 25 0 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 55978700.0 36307000.0 9150700.0 10521000.0 False True 30190879.17281667 9101403.362828273 12720892.456392271 1.0 0.30146201807276335 0.42134885783140547 24.84760943364322 -9.976829409208918 6.0444779364754835 1.0000004175352615 0.3614054379617223 0.9742472824262601 0.04894359738087398 2.7543980094190016e-07 4.6497165910799056e-08 0.04738946545906895 0.015796478129924182 1.0548011407187352e-10 9.976829409208918 -0.6385949795735392 LVQDVANNTNEEAGDGTTTATVLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVQDVANNTNEEAGDGTTTATVLAR 25 0 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 71272200.0 9186200.0 34682000.0 27404000.0 False True 11891716.987073384 32751916.212071806 22416753.188785076 1.0 2.754178916944796 1.8850728799846725 23.503453698041955 -10.07670404768868 5.729973859415208 0.99999323940054 2.3196258984649263 0.7545371537546507 0.35481105382147254 3.064382486491432e-05 4.937921319450156e-06 0.34354608383811114 0.11451477520830654 8.381002154730364e-11 10.07670404768868 1.3196326590643863 LVQFHFTK(ub)DLETLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVQFHFTKDLETLK 14 1 A0A0C4DGR2;M0QY25;Q86YD1-2;Q86YD1;Q86YD1-3;M0QYH6 A0A0C4DGR2 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 7292900.0 2715200.0 2870800.0 1706900.0 True False 3559653.4940342074 2442487.8302907567 1530286.361740953 1.0 0.686158873155558 0.4298975628683052 21.763305381648262 -7.355163772027046 0.18769816374262333 1.2067879444883458 1.2221634044765676e-10 0.9999788993738238 0.0010709168205816 0.11498519574689821 0.01295080977408097 0.02362133312230801 0.05224642923537497 4.4140396295929116e-08 7.355163772027046 -1.2067879443661296 down LVQFHFTK(ub)DLETLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVQFHFTKDLETLK 14 1 A0A0C4DGR2;M0QY25;Q86YD1-2;Q86YD1;Q86YD1-3;M0QYH6 A0A0C4DGR2 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 28034000.0 8272000.0 7476000.0 12286000.0 True False 12549228.764204934 6141849.389745396 9857666.714854894 1.0 0.48942046600220035 0.7855197239668325 23.581095367650818 -10.239483401313159 5.697735032814963 1.0000168314592464 0.6374700949845119 0.6665242884547082 0.12088201587170518 2.5846976861516654e-05 3.449775912042519e-06 0.11704893751368126 0.03901450286058749 5.7612483756634663e-11 10.239483401313159 -0.36254673647473445 LVQFHFTK(ub)DLETLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVQFHFTKDLETLK 14 1 A0A0C4DGR2;M0QY25;Q86YD1-2;Q86YD1;Q86YD1-3;M0QYH6 A0A0C4DGR2 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 17732800.0 2715200.0 3713600.0 11304000.0 True False 3719082.8155210265 3549520.8727670116 8634228.013187772 1.0 0.9544075915582267 2.3216014381702217 21.826515443171154 -6.899182864365144 0.9663928261438854 0.9418756085436416 2.4627667511086413 0.9861561464815971 0.07459972116096866 0.11201017594486926 0.18081996469537093 0.057982364004494094 0.15025548564482646 1.261296340368798e-07 6.899182864365144 1.5208911425649996 up LVQFHFTK(ub)DLETLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVQFHFTKDLETLK 14 1 A0A0C4DGR2;M0QY25;Q86YD1-2;Q86YD1;Q86YD1-3;M0QYH6 A0A0C4DGR2 PTOV1 Prostate tumor-overexpressed gene 1 protein 1 29445000.0 8272000.0 10778000.0 10395000.0 True False 10708267.065497274 10178194.825376568 8503216.66170707 1.0 0.9504987840816342 0.7940796218190133 23.352221689743267 -6.950278021826677 0.555786971788361 1.002092672627411 0.7350641230008312 0.9992228899521975 0.0024465253857403673 0.08337437646426357 0.035502404126888605 0.002636084781118209 0.012991087618136497 1.1213004028286337e-07 6.950278021826677 -0.26702854962657985 LVQGSILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVQGSILK 8 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 19897700.0 4159500.0 9936300.0 5801900.0 False True 5453144.780655297 8453842.771394048 5201575.043754659 1.0 1.5502692687316033 0.9538670350743176 22.378657028753594 -6.664246706524484 1.958351489912788 1.3529623485375926 0.9563562694179432 0.25366165299298093 0.23405748234058196 0.4744079296447429 3.5020485813451527 0.09642489015286525 0.2595164636320737 2.1664730625186153e-07 6.664246706524484 -0.3966060791196494 LVQGSILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVQGSILK 8 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 15899400.0 5195900.0 2340700.0 8362800.0 False True 5030958.998591866 3275353.7165892483 6172331.801377691 1.0 0.6510396362812735 1.226869828019924 22.262402001291214 -6.742653328314049 1.6770562049546616 0.7930117708180288 1.2274025533783932 0.6167845283641042 0.14661220137161707 0.313025607048739 1.7296450020357363 0.06913311753646952 0.16915000688690596 1.8086172625028437e-07 6.742653328314049 0.43439078256036445 LVQGSILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVQGSILK 8 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 50785400.0 2316300.0 45049000.0 3420100.0 False True 3513996.4442127584 37009653.98055645 2744115.7359169186 1.0 10.532069274431988 0.7809102198826168 21.744681300818666 -6.651386876768253 2.003754050074884 7.178682078423205 0.8220548241638335 0.19961285414481922 4.067032291016469 0.5051516354422146 3.8892398008470237 1.6452775439913683 4.5046231076490635 2.2315834054071638e-07 6.651386876768253 -6.356627254259371 LVQGSILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVQGSILK 8 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 18805600.0 4159500.0 7457300.0 7188800.0 False True 5697379.556260933 7127811.828006637 5490953.49798339 1.0 1.2510684530704614 0.9637682453417207 22.441867090276485 -6.6757923224426285 1.916946541950584 1.1594501565061208 0.9648973054835709 0.304949638836728 0.10650801332475439 0.44792540053287944 3.1785969699919794 0.04464473172962696 0.11838127446074782 2.109636727023032e-07 6.6757923224426285 -0.19455285102254993 LVQGSILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVQGSILK 8 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 8883600.0 5195900.0 2098800.0 1588900.0 False True 4320621.067398525 2087493.3478208166 1921131.6437564536 1.0 0.4831465928757577 0.44464247472486174 22.04280727672549 -13.999999999999998 0.368458019812799 8.129964590940752 0.44055376693689946 0.999788249779624 0.0036846297738197995 22.640689736572767 0.19688869014687502 127.4181172876384 0.010813295651899304 1.0000000000000041e-14 13.999999999999998 -7.689410824003852 LVQGSILKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVQGSILKK 9 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 2051910.0 696720.0 485670.0 869520.0 True False 913406.6670460767 413209.9291268322 779550.411424802 1.0 0.45238330749559535 0.853453822431403 19.80089779456605 -10.306596745948438 5.95241771737794 1.0000258823860702 0.6529185649635073 0.4996316058427599 0.16373635207800735 5.624428394808609e-05 6.55204957086739e-06 0.15854884415402412 0.05284568039723932 4.936319416967563e-11 10.306596745948438 -0.34710731742256284 LVQGSILKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVQGSILKK 9 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 9488300.0 1818300.0 2129800.0 5540200.0 True False 2758494.035536006 1749720.5497966493 4445177.041644081 1.0 0.6343028214873987 1.6114506627092755 21.395449430378132 -6.805330604246881 1.4339233428110516 0.7995683493352437 1.6268025040729954 0.847316490160628 0.15751122218454233 0.21324062653316855 0.8649494972397714 0.08639165602334746 0.20031075285319955 1.5655588434588198e-07 6.805330604246881 0.8272341547377517 LVQGSILKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVQGSILKK 9 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 2324880.0 696720.0 795360.0 832800.0 True False 954316.2121500456 760218.3652962011 636109.7920543855 1.0 0.7966105527888414 0.6665608149119142 19.864107856088943 -9.732504998506453 0.0644933481827297 1.8283211850322723 1.0703679135084006e-14 0.99998843717087 0.0004665665251306514 1.264397369953313 0.027827749538763682 0.47922513200959244 0.31126548214196276 1.8513775856774178e-10 9.732504998506453 -1.8283211850322616 LVQGSILKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVQGSILKK 9 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 4448850.0 917850.0 2447200.0 1083800.0 True False 763232.9426493467 2434016.447868831 1310417.5690749863 1.0 3.189087252208786 1.7169300430432726 19.54176391670682 -10.390700268037865 6.178941065865934 0.9997502876160429 2.453008647626026 0.565004280402184 0.6010056639358735 0.002067780793528125 0.0002039018459205304 0.5820138209188441 0.19397374394999733 4.0672393624230736e-11 10.390700268037865 1.4532583600099833 LVQGSILKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVQGSILKK 9 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 6838000.0 1818300.0 1152300.0 3867400.0 True False 2353825.1940514627 1088173.4920468933 3163572.8828750323 1.0 0.4623000445389498 1.344013519300391 21.16657575247058 -6.741634688586385 1.68056710485863 0.6806846360211849 1.3447338961356625 0.6123457412458286 0.22591192773761856 0.3148533748076907 1.7466202166660834 0.10631466561565435 0.26043451416786695 1.8128643615540346e-07 6.741634688586385 0.6640492601144776 LVQIAFK(ub)DSSWET ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVQIAFKDSSWET 13 1 Q8N165 Q8N165 PDIK1L Serine/threonine-protein kinase PDIK1L 1 5841300.0 1770300.0 2036500.0 2034500.0 True False 1714102.7955132262 2849685.0702072023 1501603.4163082852 1.0 1.6624936833814374 0.8760288007456895 20.70902220043747 -6.6833636292383485 1.890041865059103 1.417894397899388 0.8789454058504803 0.3395689617775508 0.2805760523286307 0.4310754299358898 2.9801179890690674 0.11899534838422965 0.3124842347192036 2.0731769458997524e-07 6.6833636292383485 -0.5389489920489078 LVQIAFK(ub)DSSWET ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVQIAFKDSSWET 13 1 Q8N165 Q8N165 PDIK1L Serine/threonine-protein kinase PDIK1L 1 24717700.0 9276900.0 6559500.0 8881300.0 True False 14073735.532235585 5388905.975392577 7125907.162187918 1.0 0.3829051613943864 0.5063266355877004 23.746501972071503 -9.728883997746454 6.104227493692727 1.0000000096696802 0.4446158984902894 0.9642841595728534 0.05038660585228918 38172869.95380468 60839674.87469864 3.4959705788068107 0.017248682143717265 1.8668782768780042e-10 9.728883997746454 -0.5553841111793908 LVQIEYALAAVAGGAPSVGIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVQIEYALAAVAGGAPSVGIK 21 0 A0A024RA52;P25787;H3BT36;H7C402 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 70445000.0 12416000.0 37661000.0 20368000.0 False True 18835979.731185764 30940100.303263966 16342255.872388458 1.0 1.6426063706172942 0.8676084868222397 24.166987739523012 -6.686578736302246 1.8787083704668026 1.4041666068007037 0.8704040318665055 0.35436304280544495 0.27197042684599787 0.4240859287659265 2.899371675801114 0.11593010953750245 0.3031833000758176 2.0578857681302477e-07 6.686578736302246 -0.5337625749341982 LVQIEYALAAVAGGAPSVGIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVQIEYALAAVAGGAPSVGIK 21 0 A0A024RA52;P25787;H3BT36;H7C402 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 35931000.0 12416000.0 13119000.0 10396000.0 False True 16072756.755949503 12388916.117472166 8504034.671967944 1.0 0.7708021906625493 0.5290962092623025 23.93811406161546 -6.970453326430173 0.24711914895682133 1.0794764682158402 0.21336848164658412 0.9999857047382206 0.0007269256329721411 0.07615587107282228 0.008502182810014709 0.005497912994099751 0.02327587975792292 1.0704014126266711e-07 6.970453326430173 -0.866107986569256 LVQIHVDTMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVQIHVDTMK 10 0 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8YG48;A0A2R8Y7R5;A0A2R8Y755;A0A2R8Y6J9 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 30405700.0 12546000.0 8814000.0 9045700.0 False True 16447927.49563682 7498985.556702901 8109737.736481428 1.0 0.4559228242398426 0.49305529457329605 23.971402474303694 -9.89644691250197 5.731684144479684 1.0000002485216384 0.4744890610775357 0.996269369247056 0.015159267537227704 4.8135218164227754e-08 9.27274663114315e-09 0.01467790445691793 0.004892632558943582 1.269267288268772e-10 9.89644691250197 -0.5255111874441027 LVQIHVDTMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVQIHVDTMK 10 0 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8YG48;A0A2R8Y7R5;A0A2R8Y755;A0A2R8Y6J9 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 23385300.0 6801600.0 4385700.0 12198000.0 False True 6585686.931007615 6136932.881123367 9002977.867843917 1.0 0.9318591887854 1.367052209156024 22.650902500355805 -6.866885948365215 1.15050502990215 0.9621034726800546 1.3910684651272365 0.9614717499705592 0.0375154493731751 0.1398722313363798 0.3479947336743603 0.025352091278429852 0.05971568532513313 1.3586702050060158e-07 6.866885948365215 0.4289649924471819 LVQIHVDTMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVQIHVDTMK 10 0 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8YG48;A0A2R8Y7R5;A0A2R8Y755;A0A2R8Y6J9 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 41402000.0 10677000.0 16597000.0 14128000.0 False True 16197789.59325632 13635135.67704713 11335594.607477633 1.0 0.8417898996986534 0.6998235495167204 23.949293615566827 -6.972410175658753 0.19210384377725442 1.093611509076378 0.4441151943792515 0.9999955822544799 0.00025763459195314077 0.07552825225868409 0.00614377319408764 0.004923211366144388 0.015386790547494715 1.0655892347690969e-07 6.972410175658753 -0.6494963146971265 LVQIHVDTMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVQIHVDTMK 10 0 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8YG48;A0A2R8Y7R5;A0A2R8Y755;A0A2R8Y6J9 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 39158300.0 12546000.0 9126300.0 17486000.0 False True 17184595.24290171 8723069.8893617 13356166.935474312 1.0 0.5076098544110234 0.777217429138532 24.034612535826586 -10.099549382129943 5.315040809854061 1.0000058539520535 0.6424136417744899 0.7010915019000148 0.11006683147962548 7.635145699460496e-06 1.2937719054212471e-06 0.10657349445040988 0.03552391710738789 7.951528463010042e-11 10.099549382129943 -0.35759221217756365 LVQIHVDTMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVQIHVDTMK 10 0 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8YG48;A0A2R8Y7R5;A0A2R8Y755;A0A2R8Y6J9 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 13931900.0 6801600.0 3924400.0 3205900.0 False True 5655831.761969598 3903258.478267591 3876238.867593193 1.0 0.690129877008278 0.6853525760185136 22.43130777579008 LVQIHVDTMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVQIHVDTMK 10 0 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8YG48;A0A2R8Y7R5;A0A2R8Y755;A0A2R8Y6J9 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 38582000.0 10677000.0 16462000.0 11443000.0 False True 13821586.975134738 15545875.228738984 9360491.415095137 1.0 1.12475327592311 0.6772370952724036 23.720419937659276 -6.832305350532664 1.3174793561391138 1.0665623657092203 0.6646093483344068 0.9104226737182413 0.056436434557774494 0.1779849800466514 0.6033670818702636 0.033624387530932644 0.07738233776641526 1.4712776898417446e-07 6.832305350532664 -0.4019530173748135 LVQK(ub)FGTEWAQNTIVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVQKFGTEWAQNTIVPK 17 1 P30154;P30154-2;P30154-4;P30154-3;P30154-5 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 11139200.0 1347700.0 2385300.0 7406200.0 True False 1766847.751145366 2029422.5378265772 6639877.469286917 1.0 1.1486120049172295 3.7580360079031085 20.75274629787764 -6.918618842864022 0.8349172413873485 0.9395076733904688 4.1657305767416135 0.9937882968754767 0.09982440569158874 0.09899138530003795 0.10987939297028507 0.085385519136872 0.25248462548432304 1.206094000469297e-07 6.918618842864022 3.226222903351145 up LVQK(ub)FNHSHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVQKFNHSHR 10 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 7467600.0 1447100.0 3919400.0 2101100.0 True False 1897162.113736333 3334640.7977015395 1883698.32717436 1.0 1.7576994467458498 0.9929031965879515 20.85541153257043 -10.22747622560144 4.211322325408182 0.9997925243141043 1.3753013216589733 0.2430411004380464 0.31222676174598124 221819694.5450735 120828429.00493272 481427.5252561521 0.11426328858802902 5.922755086755751e-11 10.22747622560144 0.3755087973448691 LVQK(ub)FNHSHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVQKFNHSHR 10 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 9792600.0 3169500.0 3757400.0 2865700.0 True False 3068885.957396582 5257749.414582149 2115087.200842787 1.0 1.7132436615671567 0.6892035840383826 21.549283604260086 -6.719417439062741 1.761455770951814 1.4341978690345936 0.6908561075138604 0.5097565281660796 0.30015690549471413 0.35644562359291826 2.1610898430920917 0.13532016326105745 0.33993154743271525 1.9080184106520107e-07 6.719417439062741 -0.7433417615207332 LVQK(ub)FNHSHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVQKFNHSHR 10 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 8335400.0 1447100.0 4013400.0 2874900.0 True False 1982131.9764070665 3836074.7174609913 2195907.8304240583 1.0 1.9353275983239495 1.107851473343614 20.91862159409332 -10.229279423043751 4.45029707136549 0.9998439408399683 1.5215895357246443 0.3463060050426935 0.337815714151307 0.0006498179622091185 0.00011253908994539831 0.32720887596225795 0.10902955280682072 5.898214696829474e-11 10.229279423043751 0.521745594884676 LVQK(ub)FNHSHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVQKFNHSHR 10 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 7709900.0 3169500.0 3472400.0 1068000.0 True False 2635579.682657405 3453693.4919825695 1291313.8621259318 1.0 1.3104113355815052 0.48995440002175333 21.329688879694363 -6.804176266246164 1.4386450680060219 1.1703706213360823 0.47740434398154175 0.844142437170539 0.13353274299240817 0.21484368059016612 0.8773595572443839 0.07300329636782436 0.1693776152228596 1.569725573599032e-07 6.804176266246164 -0.6929662773545405 down LVQLILHEYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVQLILHEYK 10 0 P55039;A8MZF9;J3KRL5 P55039 DRG2 Developmentally-regulated GTP-binding protein 2 0 4095770.0 667870.0 1090900.0 2337000.0 False True 914799.5875081124 1042700.4308761144 1785048.732025819 1.0 1.1398129657189726 1.951300324575178 19.803096189661545 -6.936541848163232 0.6909893187420837 0.9901210662706609 2.149527658961237 0.9976749254678928 0.020222831994793185 0.08938027609853635 0.062063769429333004 0.019203353185413864 0.07097220234064926 1.1573325073660076e-07 6.936541848163232 1.1594065926905763 LVQLLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVQLLVK 7 0 P14923 P14923 JUP Junction plakoglobin 0 6486900.0 1721900.0 2665400.0 2099600.0 False True 2257427.5749033215 2267732.7096478255 1882353.532785346 1.0 1.0045649901946225 0.8338489144512029 21.10624827175725 -6.900755106377852 0.9564658708200728 1.0069514384462912 0.81565101374822 0.9869387051934414 0.009076847732912872 0.11085212025030873 0.1742948221132401 0.00710720067093334 0.01856309810355936 1.2567384241536836e-07 6.900755106377852 -0.19130042469807118 LVQLLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVQLLVK 7 0 P14923 P14923 JUP Junction plakoglobin 0 5136470.0 2119900.0 849270.0 2167300.0 False True 2052604.9348745937 1188387.9398845413 1599619.1123936807 1.0 0.5789657423566251 0.7793117346721234 20.96902454779664 -10.073026045845518 4.928822796909352 1.000008658184798 0.6791387385120796 0.7737499656620853 0.08179090887202578 7.781968830982235e-06 1.4635578487537245e-06 0.07919584394205753 0.026397902326577315 8.452281529618601e-11 10.073026045845518 -0.3208699196727184 LVQLLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVQLLVK 7 0 P14923 P14923 JUP Junction plakoglobin 0 9937900.0 1721900.0 2916100.0 5299900.0 False True 2358532.9625978386 2787257.0597468447 4048172.774866762 1.0 1.1817757495645862 1.716394402394888 21.16945833328014 -6.951895732052206 0.5376297181274482 0.9920039621305806 1.930754821572187 0.9993417741967416 0.0078009724028932515 0.08273334373228737 0.03288029192851285 0.008608389413959364 0.04425763549065848 1.1171314230030113e-07 6.951895732052206 0.9387508594416064 LVQLLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVQLLVK 7 0 P14923 P14923 JUP Junction plakoglobin 0 4397550.0 2119900.0 930950.0 1346700.0 False True 1762790.777493435 925934.787570892 1628288.743562728 1.0 0.5252664124369351 0.9236993773464373 20.749429823230916 -10.068939070854537 7.323859666765201 1.000000041801222 0.7244828948916865 0.38933769618277425 0.16265957678875267 1.1094526131573038e-07 1.4099320380152189e-08 0.1574944814694227 0.05249815266699881 8.532198077034166e-11 10.068939070854537 -0.27551714690953555 LVQSPNSYFMDVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVQSPNSYFMDVK 13 0 P42677;H0YMV8;Q71UM5;C9JLI6 P42677;H0YMV8 RPS27;RPS27L 40S ribosomal protein S27;40S ribosomal protein S27-like 0 25024000.0 4342900.0 14852000.0 5829100.0 False True 5693583.956703431 12636139.492642578 5225960.64867548 1.0 2.2193647426179113 0.9178683740181987 22.440905645205532 -6.660862832511318 1.9696245646455246 1.7843518927161053 0.923274924181711 0.23922697938698123 0.5190756169469691 0.48249337578136264 3.5990939302180127 0.21284038536735794 0.5755477343352281 2.1834194137342012e-07 6.660862832511318 -0.8610769685343943 LVQSPNSYFMDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVQSPNSYFMDVK 13 0 P42677;H0YMV8;Q71UM5;C9JLI6 P42677;H0YMV8 RPS27;RPS27L 40S ribosomal protein S27;40S ribosomal protein S27-like 0 13178500.0 5004300.0 1645400.0 6528800.0 False True 4845441.235715332 2302416.8006476457 4818711.420198339 1.0 0.4751717518885027 0.9944835126015005 22.20819661568566 -10.906044221173007 11.04221955331265 1.0243247243976572 0.734827632261247 0.2579661272482332 0.21200813852886005 0.10029251339977013 0.0008533651174862571 0.1621615057587576 0.0684253324818925 1.2415258852488714e-11 10.906044221173007 -0.2894970921364102 LVQSPNSYFMDVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVQSPNSYFMDVK 13 0 P42677;H0YMV8;Q71UM5;C9JLI6 P42677;H0YMV8 RPS27;RPS27L 40S ribosomal protein S27;40S ribosomal protein S27-like 0 29208000.0 4342900.0 9766100.0 15099000.0 False True 5948587.492459583 9334601.409826037 11532927.17366615 1.0 1.5692130983462138 1.938767344060294 22.504115706728424 -8.548274168341178 0.11538377906509059 1.2679117073441414e-17 2.9198058440401873 0.9999603547303807 0.0024312324933706574 0.17630456066647104 0.02942972567029573 0.3736128201434251 0.32488723061980906 2.829605113626067e-09 8.548274168341178 2.9198058440401873 LVRELEK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVRELEKK 8 2 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 22208150.0 13541000.0 800750.0 7866400.0 True False 17752382.131230526 681281.2212990538 7052460.387837038 1.0 0.03837689028226377 0.39726839675392844 24.081509292114713 -10.59162222920782 6.4071382573957925 1.0018913521634154 0.21782264351809652 0.8636337894706485 0.14651684397905754 0.003964929925248137 0.0002527162422491504 0.14209632325464328 0.04728810805581335 2.5608124395328474e-11 10.59162222920782 -0.7840687086453189 LVRPPVQVYGIEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVRPPVQVYGIEGR 14 1 P48047;A0A494C0K9;H7C0C1;H7C086 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 17357700.0 3297600.0 7122400.0 6937700.0 False True 4323185.534003826 6059765.682897747 6219853.355117587 1.0 1.4016899425747347 1.4387199684574266 22.043663321644853 -11.934519264987845 0.3791534641579187 2.068845975045464e-09 1.442390650877351 0.9996784569980308 0.0035623365340511043 5.2770685081876385 0.19503941377975284 4.2106490109365 0.010055768194407668 1.1627349717803518e-12 11.934519264987845 1.442390648808505 LVRPPVQVYGIEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVRPPVQVYGIEGR 14 1 P48047;A0A494C0K9;H7C0C1;H7C086 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 16114600.0 5326700.0 3405400.0 7382500.0 False True 5157606.824188171 4765193.978926398 5448801.779747316 1.0 0.9239157115619141 1.0564593164010674 22.298270366799095 -6.751011354615389 1.645901987116698 0.955316633128371 1.056746435601886 0.6533927146633982 0.03197297612905847 0.2982846014582509 1.590110536274305 0.01534294246967639 0.037211975685435814 1.7741430953691067e-07 6.751011354615389 0.10142980247351507 LVRPPVQVYGIEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVRPPVQVYGIEGR 14 1 P48047;A0A494C0K9;H7C0C1;H7C086 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 19856600.0 3297600.0 6564400.0 9994600.0 False True 4516811.834289231 6274363.102432084 7634081.32524828 1.0 1.389113235756349 1.6901481853404645 22.106873383167745 -6.973990401073931 0.13163475035061128 0.5447943899500273 2.5422679377985946 0.9999991768862937 0.00025624899674329716 0.07502777937769603 0.003957296386309506 0.01860434736238915 0.040791832507452046 1.061719023418561e-07 6.973990401073931 1.9974735478485672 LVRPPVQVYGIEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVRPPVQVYGIEGR 14 1 P48047;A0A494C0K9;H7C0C1;H7C086 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 9300900.0 5326700.0 2090500.0 1883700.0 False True 4429387.062821021 2079238.0615682406 2277572.960755264 1.0 0.46941891328955115 0.5141959662709418 22.07867564223337 -9.94969005514702 7.220573043389234 1.0000000132492615 0.49180744103888163 0.9942111228594706 0.018280155331664317 3.896668188845375e-09 5.844319618783765e-10 0.017699684555149375 0.005899894763801468 1.1228194959544797e-10 9.94969005514702 -0.5081925722103798 LVSDGQALPEMEIHLQTNAEK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LVSDGQALPEMEIHLQTNAEK 21 0 Q12931-2;Q12931 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 14326300.0 4537400.0 7888400.0 1900500.0 False True 5948575.340244109 6711481.468742361 1703854.4908832854 1.0 1.1282502254509472 0.28643068187371484 22.504112759481043 -6.868050091081921 1.1442865563592597 1.0717524854859384 0.23890726333508652 0.962701978032735 0.07152043547194602 0.1387421887409728 0.3407427121602246 0.04855975770442995 0.11460004153432451 1.3550331152022605e-07 6.868050091081921 -0.8328452221508519 down LVSDGQALPEMEIHLQTNAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVSDGQALPEMEIHLQTNAEK 21 0 Q12931-2;Q12931 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 126466000.0 21181000.0 69564000.0 35721000.0 False True 32133125.538518462 57149760.69398725 28660728.69292952 1.0 1.7785310247981003 0.891937158698536 24.937557980520776 -6.6747454184464345 1.9202793036778119 1.494877009539471 0.8954123351392517 0.3003891026738129 0.3303431777215641 0.4502901011868202 3.2054323745063 0.13826405874838266 0.3671726808265286 2.1147283211982742e-07 6.6747454184464345 -0.5994646744002193 LVSDGQALPEMEIHLQTNAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVSDGQALPEMEIHLQTNAEK 21 0 Q12931-2;Q12931 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 19294500.0 3262200.0 2909300.0 13123000.0 False True 4468323.497640198 2780757.5062314407 10023617.676668711 1.0 0.6223268095293478 2.243261411570215 22.091302207147745 -6.845350243914583 1.2574337653607597 0.7990094409733719 2.3024345319490345 0.9332455182326593 0.1789154527456798 0.16264703687695511 0.49724213527894634 0.11146377255641698 0.257264686536753 1.4277420680635507e-07 6.845350243914583 1.5034250909756626 up LVSDGQALPEMEIHLQTNAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVSDGQALPEMEIHLQTNAEK 21 0 Q12931-2;Q12931 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 20092800.0 6979400.0 7487800.0 5625600.0 False True 5803680.339845115 7447461.735188067 6801886.950164469 1.0 1.2832308637085996 1.171995449760762 22.468536628904502 -10.119378476311951 4.367629292407547 0.9999694002004488 1.2276131566788533 0.8480875445703311 0.04541166764702309 4959756.461588872 11532645.180176187 859.2729105079582 0.015545621414380628 7.596639610611609e-11 10.119378476311951 0.2276437564784045 LVSDGQALPEMEIHLQTNAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVSDGQALPEMEIHLQTNAEK 21 0 Q12931-2;Q12931 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 75760000.0 21181000.0 30323000.0 24256000.0 False True 27419222.03992961 28635498.39394074 19841656.88757735 1.0 1.0443585289268933 0.7236404030239324 24.708684302613225 -6.871927575679297 1.1238008191081441 1.0254072586720844 0.7041525074214506 0.9665717696572275 0.0259428346313815 0.13502252524033612 0.3175259917219314 0.017893393465919446 0.04251252532419526 1.3429889035397136e-07 6.871927575679297 -0.32125475125063374 LVSEK(ub)LASYQAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVSEKLASYQAAR 13 1 P01106;H0YBT0;A0A087WUS5;P01106-2;A0A494C1T8;A0A0B4J1R1;H0YBG3 P01106 MYC Myc proto-oncogene protein 1 166480100.0 28108100.0 37535000.0 100837000.0 True False 36849991.29922765 31934924.31028407 90403354.5368051 1.0 0.8666195888885707 2.4532802139006176 25.135160942892462 -6.886478987543528 1.042963773736433 0.9074130190154125 2.5807040989498162 0.9785481547094165 0.10524747639930311 0.12204742514210712 0.2388963766252131 0.07722136715370645 0.19023264764565256 1.2987363990320593e-07 6.886478987543528 1.6732910799344038 up LVSEK(ub)LASYQAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVSEKLASYQAAR 13 1 P01106;H0YBT0;A0A087WUS5;P01106-2;A0A494C1T8;A0A0B4J1R1;H0YBG3 P01106 MYC Myc proto-oncogene protein 1 306396500.0 39717400.0 31382100.0 235297000.0 True False 38456592.87720555 43913136.18548951 173665656.9413075 1.0 1.1418883707588727 4.51588775677121 25.1967276146975 -6.915736075106624 0.8557592176303384 0.9135143859438287 5.009965141845388 0.9929120834330843 0.13680792476515052 0.1007458360843819 0.1190969655065314 0.11528597851293929 0.33243010153268604 1.2141264625313637e-07 6.915736075106624 4.096450755901559 up LVSEK(ub)LASYQAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVSEKLASYQAAR 13 1 P01106;H0YBT0;A0A087WUS5;P01106-2;A0A494C1T8;A0A0B4J1R1;H0YBG3 P01106 MYC Myc proto-oncogene protein 1 242786000.0 0.0 23983000.0 218803000.0 True False 0.0 19703046.269965727 175556491.1452381 0.0 LVSEK(ub)LASYQAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVSEKLASYQAAR 13 1 P01106;H0YBT0;A0A087WUS5;P01106-2;A0A494C1T8;A0A0B4J1R1;H0YBG3 P01106 MYC Myc proto-oncogene protein 1 139549000.0 28108100.0 2708900.0 108732000.0 True False 38500424.162841246 2589211.8408656213 83051741.00583276 1.0 0.06725151468239157 2.1571643121269894 25.198371004415353 -6.7853602851795385 1.5147070208580609 0.47553332408598586 2.1766743607673127 0.7859918863734113 0.3954582771515925 0.24233011930729728 1.0983727746061078 0.2055546945370541 0.4829533834831358 1.6392293251692525e-07 6.7853602851795385 1.7011410366813269 LVSEK(ub)LASYQAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVSEKLASYQAAR 13 1 P01106;H0YBT0;A0A087WUS5;P01106-2;A0A494C1T8;A0A0B4J1R1;H0YBG3 P01106 MYC Myc proto-oncogene protein 1 209575800.0 39717400.0 52679400.0 117179000.0 True False 33026777.879153557 52395605.61615782 141680587.1255193 1.0 1.5864582917496723 4.289870106128271 24.977132890131777 -6.941633094352124 0.6441906171717967 0.9703034592366591 5.05530944462365 0.9983700861364021 0.05784429217020888 0.08702942688729605 0.05127555227532049 0.05702994662693563 0.23105462552854414 1.1438442823534803e-07 6.941633094352124 4.085005985386991 LVSEK(ub)LASYQAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVSEKLASYQAAR 13 1 P01106;H0YBT0;A0A087WUS5;P01106-2;A0A494C1T8;A0A0B4J1R1;H0YBG3 P01106 MYC Myc proto-oncogene protein 1 185230900.0 0.0 42679900.0 142551000.0 True False 0.0 40304726.046352684 116608180.69677763 0.0 LVSGWVKPIIIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVSGWVKPIIIGR 13 1 O75874;C9J4N6 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 66972000.0 23154000.0 17942000.0 25876000.0 False True 30355118.22365493 15265123.537368227 23198599.740118884 1.0 0.5028846675837528 0.7642401379956029 24.85543645625537 -10.021647140027154 5.085430738140372 1.0000038784153755 0.6335624027874264 0.7238371437098615 0.10669792400685046 4.691843406942772e-06 9.024126072615224e-07 0.10331091501122733 0.0344366068949959 9.513774645040742e-11 10.021647140027154 -0.36644147562794915 LVSGWVKPIIIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVSGWVKPIIIGR 13 1 O75874;C9J4N6 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 55356000.0 24076000.0 9805000.0 21475000.0 False True 23311720.5585361 13720187.632399505 15850053.263809493 1.0 0.5885531957174888 0.6799177788704938 24.47455215300532 -10.396261839403376 6.597743899228201 1.000038009468885 0.6342354872939983 0.9552954622180111 0.03729943488115779 2.085625074590445e-05 1.908484226576319e-06 0.0361187632145862 0.01203834084313934 4.015486411631431e-11 10.396261839403376 -0.36580252217488674 LVSGWVKPIIIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVSGWVKPIIIGR 13 1 O75874;C9J4N6 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 31908200.0 6876200.0 10547000.0 14485000.0 False True 10431698.117556347 8664805.44591288 11622033.400998974 1.0 0.8306227182063657 1.1141075278471984 23.314470689410214 -6.744843471322455 1.668663165852921 0.8997940355467826 1.1144663320712418 0.6266389790230569 0.07116275227715527 0.3091069863959577 1.6916455695955028 0.03371148168353811 0.08229885515382224 1.7995193821159252e-07 6.744843471322455 0.21467229652445918 LVSGWVKPIIIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVSGWVKPIIIGR 13 1 O75874;C9J4N6 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 65907000.0 23154000.0 16866000.0 25887000.0 False True 31714659.51332265 16120804.351596419 19773023.75950036 1.0 0.5083076595800883 0.6234663736873521 24.91864651777826 -9.90131901249694 6.744163387178671 1.0000000169012453 0.5658870166337506 0.9498682675492162 0.04701334816633387 1.1988696503008514e-08 1.910963920024182e-09 0.04552048065932448 0.015173492874801232 1.2551076813637959e-10 9.90131901249694 -0.43411300026749466 LVSGWVKPIIIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVSGWVKPIIIGR 13 1 O75874;C9J4N6 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 42471200.0 24076000.0 8858700.0 9536500.0 False True 20020260.747644655 8810976.42478572 11530538.058205953 1.0 0.4401029804680398 0.5759434506647222 24.254957428439596 -10.12594229235982 7.8010750037908565 1.0000000747058944 0.5080232155665514 0.9459143309439408 0.05545663973360292 7.206407545022113e-08 8.102743104462139e-09 0.053695668532396816 0.017898553510405726 7.482689214495696e-11 10.12594229235982 -0.49197685913934297 LVSGWVKPIIIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVSGWVKPIIIGR 13 1 O75874;C9J4N6 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 40552200.0 6876200.0 21300000.0 12376000.0 False True 8901376.450165916 20114636.275795218 10123694.988483582 1.0 2.2597220091079615 1.1373179243862765 23.085597011502664 -6.618506562952793 2.1228865368041605 1.836769293269318 1.1416229106551818 0.07756455380739713 0.5419390937655355 0.5894437030201187 5.045947107633304 0.209948545070814 0.6007766913128452 2.407096143322683e-07 6.618506562952793 -0.6951463826141362 LVSK(ub)SVFPEQANNNEWAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVSKSVFPEQANNNEWAR 18 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 21124400.0 4392900.0 8003000.0 8728500.0 True False 4253449.794051888 11198639.63509367 6442244.000612866 1.0 2.6328369152855826 1.5145926982897113 22.020201994552625 -10.50931278479572 5.359735463019329 0.9974826982741757 2.0737148067876516 0.5514203940146467 0.45652128990968116 0.013751056318023926 0.001258916853870849 0.4426305086612483 0.14734161275077456 3.0951892988225e-11 10.50931278479572 1.076232108513476 LVSK(ub)SVFPEQANNNEWAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVSKSVFPEQANNNEWAR 18 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 77608200.0 8404200.0 19903000.0 49301000.0 True False 12749785.829319531 16351154.147151219 39556635.740604065 1.0 1.2824650049846285 3.1025333499829655 23.603969677133023 -6.93434587675194 0.7102221937114883 0.976277879509045 3.5211905280342446 0.9973254323735146 0.04818553863880487 0.090443346549994 0.0670822425914042 0.04509511529343589 0.16093167802188402 1.1631992761262776e-07 6.93434587675194 2.5449126485252 up LVSK(ub)SVFPEQANNNEWAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVSKSVFPEQANNNEWAR 18 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 19972800.0 5635400.0 7163600.0 7173800.0 True False 7718959.67095874 6847088.465142663 5479496.189048704 1.0 0.8870480941756513 0.7098749601794614 22.879974989526705 -6.964504011621547 0.3664703755407507 1.014181774395188 0.5766082445758144 0.9999025440527942 0.0011787631828001225 0.0781297473707644 0.015456242713125488 0.002348571823776328 0.015076308137157698 1.0851655258040359e-07 6.964504011621547 -0.4375735298193736 LVSK(ub)SVFPEQANNNEWAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVSKSVFPEQANNNEWAR 18 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 19571200.0 4392900.0 9283500.0 5894800.0 True False 3652890.988466864 9233487.942869522 7127375.4255242925 1.0 2.527720638809663 1.9511601764266409 21.8006072699869 -10.577110516940222 7.172264541128469 0.9988514515133405 2.2394404076181242 0.8603682856235627 0.23537982311692315 0.004325370458669109 0.00025503144301977263 0.22803441144514255 0.07596851124709093 2.6478262481845166e-11 10.577110516940222 1.2405889561047836 LVSK(ub)SVFPEQANNNEWAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVSKSVFPEQANNNEWAR 18 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 71484200.0 8404200.0 11229000.0 51851000.0 True False 10879402.571548866 10604096.2789157 42414650.036187924 1.0 0.9746947232789115 3.8986194101418827 23.375095999225472 -6.904946374608585 0.9294504855188844 0.8943748923378534 4.238343870541814 0.988871001894188 0.14478276691360542 0.10785589505969502 0.15759091283544235 0.1156501444143185 0.309107463857416 1.2446682902232373e-07 6.904946374608585 3.3439689782039608 up LVSLGTCFGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVSLGTCFGK 10 0 Q9Y221;Q9Y221-2;J3QLW7 Q9Y221 NIP7 60S ribosome subunit biogenesis protein NIP7 homolog 0 17792600.0 6185300.0 5700100.0 5907200.0 False True 8108988.198530413 4849667.298815774 5295979.609863587 1.0 0.5980607173278013 0.6530999281542146 22.9510904822837 -10.230528215753495 5.447268709169659 1.0000240901271205 0.6255803227411595 0.9840519934727554 0.022469663728471506 6.574219949392798e-06 9.286661849094861e-07 0.021757555925950585 0.007252052784588588 5.881279027180857e-11 10.230528215753495 -0.37444376738596097 LVSLIGSK(ub)TQIPTQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVSLIGSKTQIPTQR 15 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 15019200.0 5130700.0 6817900.0 3070600.0 True False 6726397.385769472 5800695.89596605 2752883.7672750433 1.0 0.8623778173198838 0.4092657048629197 22.681402583030113 -6.949342858459033 0.566010736839683 1.0057500631065068 0.24401383202775737 0.9991487093238323 0.007363380704388874 0.08375067031066795 0.03706253807761781 0.007837023344119821 0.03771705690861971 1.1237174928124854e-07 6.949342858459033 -0.7617362310787494 down LVSLIGSK(ub)TQIPTQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVSLIGSKTQIPTQR 15 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 35001000.0 14313000.0 10701000.0 9987000.0 True False 13858641.649540083 14973965.104977798 7371105.096422146 1.0 1.0804785550880254 0.5318778912698681 23.72428252330945 -6.869614728241286 1.1360630282772106 1.0454161962923634 0.49997403418614983 0.9643007114384362 0.04570248274227216 0.1372284425511449 0.33125352523974017 0.03122669757145326 0.07388525354959638 1.3501601068671934e-07 6.869614728241286 -0.5454421621062135 LVSLIGSK(ub)TQIPTQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVSLIGSKTQIPTQR 15 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 30514000.0 6025900.0 8684100.0 15804000.0 True False 9141730.852299636 7134354.505817012 12680332.47286074 1.0 0.7804161620031002 1.3870822361468842 23.124035913559428 -6.808795244488732 1.4196987264340761 0.8801585664674865 1.3973950712925123 0.856634665766949 0.0949609134140264 0.20844684701361793 0.8282894142456829 0.05259922726086114 0.12173454681067977 1.553119081746085e-07 6.808795244488732 0.5172365048250258 LVSLIGSK(ub)TQIPTQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVSLIGSKTQIPTQR 15 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 16593700.0 5130700.0 6113800.0 5349200.0 True False 7027658.441954071 5843672.100367019 4085829.1302321344 1.0 0.8315247743802074 0.5813926735312498 22.744612644553005 -6.9654276805265365 0.35064237179800967 1.0239943076600284 0.3804745633768626 0.9999216826278718 0.0015219278610616332 0.0778162078062067 0.01435040610425335 0.0034278831394628064 0.02149039720893822 1.0828600198508936e-07 6.9654276805265365 -0.6435197442831658 LVSLIGSK(ub)TQIPTQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVSLIGSKTQIPTQR 15 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 30818000.0 14313000.0 12293000.0 4212000.0 True False 11901893.673410775 12226775.169030547 5092709.725912387 1.0 1.0272966222463882 0.42789070929861095 23.504687798743728 -6.896231791524379 0.9847916801815843 1.027562536132983 0.36957555824764887 0.984596221157263 0.03429878134664802 0.1142321041465018 0.19347886999175118 0.0262957224089517 0.06721036136741379 1.2698961557008068e-07 6.896231791524379 -0.6579869778853341 down LVSLIGSK(ub)TQIPTQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVSLIGSKTQIPTQR 15 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 1 13918000.0 6025900.0 7892100.0 0.0 True False 7800646.338247108 7452897.697286543 0.0 1.0 0.9554205349298391 0.0 22.895162235651878 -7.060636747115168 1.0373613311869843 1.0094517374652863 4.250293433561234e-20 0.9883619842801329 0.04976015277545177 0.08471454008194154 0.17502001811027024 0.04003130674130581 0.07144704992973502 8.696875498043019e-08 7.060636747115168 -1.0094517374652863 down LVSLYFDTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVSLYFDTK 9 0 O00231;O00231-2;J3QRY4;J3KSW3 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 29262700.0 3742000.0 8104700.0 17416000.0 False True 5125518.523747666 7746607.55534113 13302699.493779033 1.0 1.5113802670791991 2.595386092576716 22.289266531756635 -6.95889211487671 0.4507841358154156 0.9653218636224472 3.1844734946425954 0.9997268530073833 0.01099305845511805 0.08009939778414636 0.022612482040103632 0.014505847446813828 0.08965472004398936 1.0992788825253056e-07 6.95889211487671 2.2191516310201482 LVSLYFDTKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVSLYFDTKR 10 1 O00231;O00231-2;J3QRY4;J3KSW3 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 31902300.0 8634300.0 10880000.0 12388000.0 False True 13098864.35188281 8938378.994172009 9939506.37014671 1.0 0.6823781630265696 0.7588067257691711 23.642938402315657 -9.485504896059114 11.851511917746494 1.0000005305982709 0.7205924463531972 0.9468645655249094 0.031201830083781017 0.0 0.0 0.030211042070739904 0.010070347356913298 3.269603607955815e-10 9.485504896059114 -0.2794080842450737 LVSLYFDTKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVSLYFDTKR 10 1 O00231;O00231-2;J3QRY4;J3KSW3 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 5635300.0 1369900.0 2943200.0 1322200.0 False True 1876389.0501555102 2813159.6921391306 1009923.5915637724 1.0 1.4992411578536888 0.5382271824065871 20.839527556312895 -6.765526398924443 1.5916372169538318 1.2879838188655097 0.53371917018508 0.7131416272394435 0.2101831242604074 0.27372261875224474 1.3677707277442546 0.1041345764374065 0.24890876828181893 1.7158274090609517e-07 6.765526398924443 -0.7542646486804298 LVSLYFDTKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVSLYFDTKR 10 1 O00231;O00231-2;J3QRY4;J3KSW3 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 36380300.0 8634300.0 12858000.0 14888000.0 False True 11177271.55749795 12142440.996909596 12178536.763780182 1.0 1.0863510772236888 1.089580467033617 23.414064724408107 -13.169956388533306 0.4780757981394514 0.02472340890367289 1.0894828609667757 0.9999132164849633 0.0003864532912282484 18.35404294243494 0.23966264394788528 18.547224257753054 0.0006863959562287582 6.76150870453672e-14 13.169956388533306 1.0647594520631027 LVSPLCLAPYFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVSPLCLAPYFR 12 0 Q9BXW9;Q9BXW9-1;Q9BXW9-3;H7BZJ7 Q9BXW9 FANCD2 Fanconi anemia group D2 protein 0 3769500.0 1060300.0 1366100.0 1343100.0 False True 1390063.5679598066 1162283.2050160926 1204128.8959249347 1.0 0.836136729143958 0.8662401660466738 20.40671942859195 -10.05005522988954 4.895445850670062 1.0000033283842948 0.8511884475937049 0.9702222779987466 0.012289676658213365 4.4646391526751715e-07 8.660699335528875e-08 0.011899694392772338 0.003966476084830376 8.911376036035499e-11 10.05005522988954 -0.1488148807905899 LVSPLCLAPYFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVSPLCLAPYFR 12 0 Q9BXW9;Q9BXW9-1;Q9BXW9-3;H7BZJ7 Q9BXW9 FANCD2 Fanconi anemia group D2 protein 0 5356800.0 1060300.0 1746000.0 2550500.0 False True 1452321.563530105 1668855.946750111 1948124.4291963396 1.0 1.1490953440735836 1.3413864244094158 20.46992949011484 -6.967645439166205 0.30929984749693934 0.970129963870193 1.5264580000443897 0.9999577547110488 0.0009082528014343623 0.07707435281442652 0.011750908159855465 0.0030521056033123097 0.017083405687601447 1.0773444056571983e-07 6.967645439166205 0.5563280361741967 LVSQTGPVHAPIFTMSVEVDGNSFEASGPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVSQTGPVHAPIFTMSVEVDGNSFEASGPSK 31 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 50348000.0 16538000.0 18938000.0 14872000.0 False True 25089355.08975111 15558365.936730636 11932542.681370825 1.0 0.6201182087412904 0.4756018095596732 24.580572051627588 -13.999999999999998 0.133971448564946 2.807354740187042 0.2830657859583475 0.9996280224205676 0.0042653643860720005 11.932591805200131 0.11419773996645007 5.660341481403722 0.17152178047028685 1.0000000000000041e-14 13.999999999999998 -2.5242889542286946 LVSSDPEINTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVSSDPEINTK 11 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 11984700.0 3363300.0 1339400.0 7282000.0 False True 3256533.8824773394 1874229.4048787274 5374625.744682691 1.0 0.5755289128000557 1.6504129662529592 21.634905806539685 -6.799551187122146 1.4575681439491694 0.7656676118058733 1.6651172400788161 0.8309015537168678 0.18177353914606845 0.22139512411118087 0.928615602319056 0.09810757868594026 0.22824265361506535 1.586531914989266e-07 6.799551187122146 0.8994496282729428 LVSSDPEINTK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVSSDPEINTKK 12 1 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 1 21388100.0 4704600.0 5096500.0 11587000.0 True False 6090197.441530285 4812875.294816438 9478284.89265992 1.0 0.7902658889178978 1.556318162696267 22.538057569754507 -6.8337228415232545 1.3110744313238802 0.8881844500475684 1.5785621160343895 0.9131356329330361 0.09526560142439129 0.17626310165990608 0.591204488203074 0.057026163165015416 0.1312479055244565 1.4664834242127867e-07 6.8337228415232545 0.690377665986821 LVSSEQALK(ub)ELGLAEHQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVSSEQALKELGLAEHQLR 19 1 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;J3QRY6 Q5TA45-4 CPSF3L Integrator complex subunit 11 1 48808100.0 5732900.0 15955700.0 27119500.0 True False 5550912.2275308 22326894.21787628 20016089.38243918 1.0 4.022202712401365 3.605909904891956 22.404293450334464 -9.775822465517201 6.252827813413245 0.9999999376607691 3.814056308649191 0.9838518337631902 0.16995082700716177 1.4849007669083408e-07 2.82348223528966e-08 0.16455418066410124 0.05485139355474669 1.6756277129666933e-10 9.775822465517201 2.814056370988422 LVSSEQALK(ub)ELGLAEHQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVSSEQALKELGLAEHQLR 19 1 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;J3QRY6 Q5TA45-4 CPSF3L Integrator complex subunit 11 1 97969800.0 18720700.0 19532100.0 59717000.0 True False 28400670.5664956 16046444.150006168 47913908.775109105 1.0 0.5650022985350293 1.6870696296739331 24.759421657728 -6.801580087938138 1.4493929974008026 0.7604695298340453 1.703179916987473 0.8367539010384375 0.18663249717328192 0.21851303033070082 0.9060756667564045 0.1012904784314694 0.23534755028312018 1.5791373732804677e-07 6.801580087938138 0.9427103871534278 LVSSEQALK(ub)ELGLAEHQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVSSEQALKELGLAEHQLR 19 1 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;J3QRY6 Q5TA45-4 CPSF3L Integrator complex subunit 11 1 51858200.0 5732900.0 19394400.0 26730900.0 True False 4767160.360532148 19289918.517713018 32320207.600282848 1.0 4.046416956605111 6.779760938580009 22.18469872576874 -7.474893706062737 0.26113824999188495 3.805976596462278e-18 9.521134442869496 0.9998362306508327 0.030210841734518136 0.13273737970066593 0.026519842173960632 0.22010352828303095 0.5728324984941879 3.3504743226242866e-08 7.474893706062737 9.521134442869496 LVSSEQALK(ub)ELGLAEHQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVSSEQALKELGLAEHQLR 19 1 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;J3QRY6 Q5TA45-4 CPSF3L Integrator complex subunit 11 1 110232600.0 18720700.0 24246900.0 67265000.0 True False 24234315.190166228 22897538.7002619 55023460.197183885 1.0 0.9448395186983966 2.2704772041386687 24.53054797982045 -6.897191544791402 0.9788636259910591 0.9405578925592737 2.4019487582780417 0.9851161542709682 0.07470318655951695 0.113501757864923 0.18931294767976592 0.05752699125561752 0.1476721028315195 1.267092893583773e-07 6.897191544791402 1.461390865718768 up LVSSPCCIVTSTYGWTANMER ddPTM_RPMI8226_Bortezomib_1h_R1 2 LVSSPCCIVTSTYGWTANMER 21 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 48948820.0 14939920.0 29833700.0 4175200.0 False True 19586379.798391085 25382628.250851776 3743190.355346435 1.0 1.2959326078695166 0.1911119050011436 24.223347429374225 -6.835411137900006 1.3033984084975052 1.1576446436180825 0.15792388674935706 0.9162902448039755 0.1351052263966598 0.17423203443829574 0.5769182333417494 0.08133266366364421 0.18722060801306564 1.4607936155667096e-07 6.835411137900006 -0.9997207568687254 down LVSSPCCIVTSTYGWTANMER ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVSSPCCIVTSTYGWTANMER 21 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 23055700.0 18553000.0 3300300.0 1202400.0 False True 17964045.17039875 4618127.000837142 887455.3687732031 1.0 0.2570761182702277 0.04940175558206438 24.098608919087415 -9.98675082019782 0.32489305258846435 1.4681936940971791 7.88826313415358e-18 0.9987030402439312 0.014696013467391062 1.4314628274734227 0.15123643044445062 0.6971190532474622 0.06683284631953298 1.0309774820430193e-10 9.98675082019782 -1.4681936940971791 LVSSPCCIVTSTYGWTANMER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVSSPCCIVTSTYGWTANMER 21 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 136267000.0 11322000.0 102440000.0 22505000.0 False True 17176301.74907258 84158781.63262689 18056876.8857081 1.0 4.899703257551991 1.0512668646312682 24.033916105657486 -6.643029536280025 2.0330182254819125 3.5441358258975657 1.0671042481591602 0.16664068206380034 1.6672696840280248 0.5256585350382897 4.15583685421661 0.6669088892234994 1.8468605788552566 2.2749427071165944e-07 6.643029536280025 -2.4770315777384058 LVSSPCCIVTSTYGWTANMER ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LVSSPCCIVTSTYGWTANMER 21 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 66889420.0 14939920.0 20877200.0 31072300.0 False True 20463612.1601572 19954776.272331867 23733662.69410606 1.0 0.9751346006832537 1.1597983048327936 24.286557490897117 -6.872931168206375 1.1184244041612474 0.9856529018521507 1.1712354401667926 0.9675244448400638 0.014745233022307307 0.13407791065775998 0.3116707800371037 0.010212159259755844 0.024309474421443898 1.3398890310335977e-07 6.872931168206375 0.1855825383146419 LVSSPCCIVTSTYGWTANMER ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LVSSPCCIVTSTYGWTANMER 21 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 81152300.0 16691000.0 38537300.0 25924000.0 False True 21606828.528797746 36392665.37799076 21206098.00270264 1.0 1.6843131480164402 0.9814535240300996 24.364983991774295 -6.652292010916299 2.0005650052068757 1.4432485304755964 0.9844196953087491 0.20333720816109568 0.2919093381696882 0.5029222634637506 3.8607914073552863 0.11823688945619876 0.3233276675906747 2.2269372977019657e-07 6.652292010916299 -0.45882883516684736 LVSTLISK(ub)AGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVSTLISKAGR 11 1 Q96P70 Q96P70 IPO9 Importin-9 1 17074400.0 1042300.0 8859500.0 7172600.0 True False 1349277.89680462 8366461.036873592 5867260.397090923 1.0 6.2006952434981475 4.348444757737347 20.363756085180675 -9.610530002802287 7.480345298087619 0.9999999998403508 5.274570000618148 0.8765596096658859 0.7561780943242714 0.0 0.0 0.7321662915204924 0.24405543050683076 2.4517150736617235e-10 9.610530002802287 4.274570000777797 LVTGTVLAVFGSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVTGTVLAVFGSVR 14 0 A0A087WWF6;P49005;F8W8R3;C9JLE1 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 0 3839220.0 1702500.0 1229000.0 907720.0 False True 1648455.0694013822 1719746.1091503305 669960.9009837093 1.0 1.0432471840283988 0.40641744711125066 20.652683134503423 -6.890637925023309 1.0185780652644505 1.0336960650664209 0.35094986767539227 0.9813042746919485 0.03972728430919007 0.11862800677295393 0.2188252735554799 0.029692319821925182 0.07419713573147438 1.2863586610909203e-07 6.890637925023309 -0.6827461973910286 down LVTGTVLAVFGSVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVTGTVLAVFGSVR 14 0 A0A087WWF6;P49005;F8W8R3;C9JLE1 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 0 21156000.0 4037200.0 8420000.0 8698800.0 False True 6124727.5588549515 6917385.214239723 6979478.367180513 1.0 1.1294192513491919 1.1395573599171425 22.546214240667037 -13.30919954255186 0.36892382646807736 7.836965217396492e-10 1.1406510393152538 0.9997675702406333 0.0009685898584080755 13.5567959293742 0.19592080172356788 10.496810816785134 0.0028440958234589764 4.9068237360993303e-14 13.30919954255186 1.1406510385315574 LVTGTVLAVFGSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVTGTVLAVFGSVR 14 0 A0A087WWF6;P49005;F8W8R3;C9JLE1 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 0 3675400.0 543500.0 757700.0 2374200.0 False True 744446.6375352365 724222.3086211672 1813462.8581838678 1.0 0.9728330710431718 2.4359877078470005 19.50580891354316 -6.902670333118284 0.9442271589438137 0.9435438014055509 2.5981812109000972 0.9878487683902593 0.07533566568780377 0.10946645848561536 0.16653961208280127 0.059525278305039314 0.15705710728861091 1.2512084447013668e-07 6.902670333118284 1.6546374094945464 up LVTGTVLAVFGSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVTGTVLAVFGSVR 14 0 A0A087WWF6;P49005;F8W8R3;C9JLE1 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 0 4048000.0 1702500.0 1001000.0 1344500.0 False True 1415704.1835381705 995607.4143170574 1625628.7337343807 1.0 0.7032594986254864 1.1482827787310486 20.4330884099377 -6.727049678176757 1.7347589557992413 0.820830212206593 1.147840920702312 0.5452057168307374 0.12477395354796407 0.3417899081918987 2.0138343579434346 0.05704025104226763 0.14197508234136313 1.8747800430321648e-07 6.727049678176757 0.3270107084957189 LVTGTVLAVFGSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVTGTVLAVFGSVR 14 0 A0A087WWF6;P49005;F8W8R3;C9JLE1 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 0 13622300.0 4037200.0 6375400.0 3209700.0 False True 5226234.985109475 6020603.385572984 2625567.5343031436 1.0 1.1519963037878727 0.502382220046339 22.317340562759487 -6.845057900921534 1.2586967541703018 1.0808863257274208 0.4787851999565115 0.9328032921929531 0.07191725566626729 0.16297574568453604 0.4993670476701879 0.04476043903360558 0.10330335477462155 1.4287034684967836e-07 6.845057900921534 -0.6021011257709094 LVTLPDITSVAK(ub)SLGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVTLPDITSVAKSLGAK 17 1 Q96GA7;H0YIA2;H0YID3 Q96GA7 SDSL Serine dehydratase-like 1 5511700.0 2414200.0 1851800.0 1245700.0 True False 2007514.2671940408 1841823.9858464769 1506170.1105339653 1.0 0.917464954518528 0.7502662049018369 20.93697881018604 -6.959793470302425 0.4383353104811207 1.0060831444012241 0.6551471693458797 0.9997624583124369 0.0016011514979149305 0.07977499236001549 0.021404587922713998 0.0021999441282334314 0.013857910669988031 1.0969997527686614e-07 6.959793470302425 -0.35093597505534446 LVTSPCCIVTSTYGWTANMER ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVTSPCCIVTSTYGWTANMER 21 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 60590000.0 0.0 60590000.0 0.0 False True 0.0 49777241.10816922 0.0 0.0 LVTSPCCIVTSTYGWTANMER ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LVTSPCCIVTSTYGWTANMER 21 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 18580600.0 3150000.0 5676800.0 9753800.0 False True 4314640.125549217 5425980.205332769 7450153.325816609 1.0 1.2575742234451335 1.726714884446653 22.040808801790494 -6.961832345769953 0.4087906615628599 0.97658277917621 2.025082377445503 0.9998322361209431 0.003896609597075474 0.0790529516071161 0.018759805483726074 0.006039205906445555 0.039185202410590154 1.0918617553728627e-07 6.961832345769953 1.0484995982692933 LVTVWSAPNYCYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVTVWSAPNYCYR 13 0 O00743-2;O00743;O00743-3 O00743-2 PPP6C Serine/threonine-protein phosphatase 6 catalytic subunit;Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed 0 15139800.0 4238300.0 4068100.0 6833400.0 False True 5805314.045750858 3888357.890592284 5219491.658290643 1.0 0.6697928587409201 0.8990885966127876 22.468942682925334 -10.094736166675368 5.378297728824667 1.000002916005173 0.7844407276767179 0.5409403110246087 0.09360959299731682 3.27304969949312e-06 5.509721428445697e-07 0.0906383249161491 0.0302123662269196 8.040144115470123e-11 10.094736166675368 -0.2155621883284552 LVVDSHVQYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVVDSHVQYR 10 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 7850700.0 2896700.0 2037500.0 2916500.0 False True 3797601.7516826987 1733512.942112793 2614728.557043465 1.0 0.4564757063703907 0.6885210003615813 21.856657189662172 -10.307299605353327 5.741506309630227 1.0000450603027495 0.5724983533659855 0.8190216605292711 0.09473209458209793 5.4646838726250044e-05 6.592888089404168e-06 0.09173359110935654 0.0305746520556495 4.9283369703864756e-11 10.307299605353327 -0.427546706936764 LVVDSHVQYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVVDSHVQYR 10 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 2577190.0 781290.0 0.0 1795900.0 False True 756488.3766065234 0.0 1325499.9141548541 1.0 0.0 1.7521748583908434 19.52895839013599 -6.751905115443048 1.6428243380393661 0.41334273241509567 1.7561658544026542 0.657131004525105 0.4202513540172484 0.2967260813658392 1.5761949055345246 0.2020321381849712 0.4894965727898735 1.7704957335588688e-07 6.751905115443048 1.3428231219875584 LVVDSHVQYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVVDSHVQYR 10 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 11421500.0 1513600.0 6782400.0 3125500.0 False True 2296241.8589821802 5572027.728866934 2507743.5550446874 1.0 2.4265857305365737 1.092107760876834 21.130843175787916 -6.630460238334304 2.079110725987163 1.9395766351969437 1.0975281542535158 0.11898002557327014 0.6118666825297143 0.5578567362070942 4.596176229280631 0.24066841750006238 0.6776612674283727 2.3417458630046477e-07 6.630460238334304 -0.8420484809434279 LVVDSHVQYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVVDSHVQYR 10 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 6061800.0 2896700.0 1210600.0 1954500.0 False True 3967688.270374091 1157111.6890811466 1492887.3541910395 1.0 0.2916337197458431 0.3762612515045905 21.919867251185064 -10.636299322051796 6.621287433809708 1.0026022064160842 0.3339474856336578 0.9880369786133545 0.03454904516668489 0.0013302423609664563 7.30688226757182e-05 0.03352975636951034 0.011150656379828212 2.3104718306185165e-11 10.636299322051796 -0.6686547207824265 LVVDSHVQYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVVDSHVQYR 10 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 2223940.0 781290.0 862940.0 579710.0 False True 649677.2520155873 858291.1709398204 700924.6807238065 1.0 1.321103930108404 1.078881365399861 19.309363665570267 -9.980982977741183 5.254422883726164 0.9999994989916184 1.1999926477376506 0.4761504356519143 0.09888694795746723 1.024644551399464e-06 1.9876257387572934e-07 0.09574729795316728 0.03191562521588287 1.0447611680406038e-10 9.980982977741183 0.19999314874603213 LVVDSHVQYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVVDSHVQYR 10 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 7627700.0 1513600.0 3843700.0 2270400.0 False True 1959385.0375165227 3629794.7161161485 1857210.4962712605 1.0 1.8525173187587638 0.9478537708061882 20.901969497880366 -6.659575744834591 1.9741068785037943 1.5489600720759056 0.951614277272646 0.23376663047326118 0.3630226245000397 0.48555509080180104 3.6370491831216833 0.148581624976809 0.4024801907431975 2.1898998566755726e-07 6.659575744834591 -0.5973457948032596 LVVECVMNNVTCTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVVECVMNNVTCTR 14 0 Q01469;I6L8B7 Q01469 FABP5 Fatty acid-binding protein, epidermal 0 12186000.0 2356600.0 5583900.0 4245500.0 False True 3089525.4213468595 4750803.885871719 3806216.385711646 1.0 1.5377131558932553 1.2319744512904347 21.558953813650398 -10.132363024864201 4.740462844111463 0.9999703330790403 1.3848438035954027 0.6787199669537034 0.12481730349497962 87162028.0143728 0.7799305613759865 28225.915717825024 0.042728282930138986 7.372876769228537e-11 10.132363024864201 0.38487347051636245 LVVECVMNNVTCTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVVECVMNNVTCTR 14 0 Q01469;I6L8B7 Q01469 FABP5 Fatty acid-binding protein, epidermal 0 15804400.0 2356600.0 5448600.0 7999200.0 False True 3227898.7047204003 5207862.8358892575 6109953.708695294 1.0 1.6133910361788633 1.8928579449411616 21.62216387517329 -10.48063568681432 0.16644070574476472 1.5826624856951891e-15 2.223001694951702 0.999590349451543 0.007547597500865535 2.2642530652941733 0.08647228921193262 1.1517612732398097 0.22121248793477125 3.306467917985841e-11 10.48063568681432 2.2230016949517 LVVFELENFQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVVFELENFQGR 12 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 10359300.0 3611300.0 4080800.0 2667200.0 False True 4734449.271878943 3471960.546833813 2391223.7295890017 1.0 0.7333398981495285 0.5050690359683601 22.174765185315874 -6.972933303605179 0.17442406359181428 1.1900596510754067 0.04221016517330283 0.9999971501153881 0.0003413937620086716 0.07536182195083804 0.005466815302192936 0.009239794096022748 0.026066829235220416 1.0643064556062083e-07 6.972933303605179 -1.1478494859021038 LVVFELENFQGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVVFELENFQGR 12 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 22589000.0 8671100.0 5341500.0 8576400.0 False True 8395840.67682016 7474388.805554521 6329983.553515053 1.0 0.8902490046280118 0.7539427911002797 23.001243358995886 -6.968204292498572 0.29797468067823707 1.0242163236487376 0.6157167014156655 0.9999647878457072 0.0005972111470003372 0.076889794518412 0.011104749095785552 0.0022843926988483764 0.012251187572814029 1.0759589625454297e-07 6.968204292498572 -0.4084996222330721 LVVFELENFQGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVVFELENFQGR 12 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 30300300.0 5812100.0 16578000.0 7910200.0 False True 8817380.621425953 13619526.375494793 6346745.5028361725 1.0 1.5446227128269567 0.719799425173252 23.07191870745031 -6.7286363024632285 1.7282604068788747 1.328244842254276 0.7204135869362561 0.5529431443855808 0.2289712505692306 0.33878132340286377 1.981786261956075 0.10501918011469136 0.2609955085021805 1.8679433349323956e-07 6.7286363024632285 -0.60783125531802 LVVFELENFQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVVFELENFQGR 12 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 18304400.0 3611300.0 5237500.0 9455600.0 False True 4946495.201712969 5006089.931903605 7222382.024194823 1.0 1.0120478698068884 1.4601008855105562 22.237975246838765 -6.9126660706833905 0.8773919306316144 0.987269186168618 1.5214298356518798 0.9918889978187122 0.019283020400670807 0.10268166043556279 0.12940354798755543 0.015998314487184227 0.04502201291357909 1.2227394639995452e-07 6.9126660706833905 0.5341606494832618 LVVFELENFQGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVVFELENFQGR 12 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 16543700.0 8671100.0 3447500.0 4425100.0 False True 7210403.844862161 3428927.633224828 5350367.950649314 1.0 0.475552785530611 0.7420344360408837 22.781648634430162 -10.507618239205335 7.479812921579929 1.000081185531438 0.6087936107857655 0.741837662841043 0.10879067826080745 0.00014731808414618916 9.697554999095076e-06 0.10535777451764587 0.03511204042722636 3.1072898097966045e-11 10.507618239205335 -0.39128757474567244 LVVFELENFQGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVVFELENFQGR 12 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 21586400.0 5812100.0 10193000.0 5581300.0 False True 7523878.023619038 9625750.589632876 4565560.668974096 1.0 1.2793602659978827 0.6068095009836469 22.843045029542758 -6.793883501756366 1.480679931628343 1.1553500332700604 0.5988609848116664 0.8136917751544626 0.1190773317191381 0.22960968177770208 0.9943293049674033 0.06328582651477345 0.14776614440099745 1.6073723681947603e-07 6.793883501756366 -0.556489048458394 LVVLGIRPIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVVLGIRPIR 10 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 66764000.0 35597000.0 18158000.0 13009000.0 False True 46668011.72183834 15448897.17932963 11662953.471139537 1.0 0.3310382553131207 0.2499132283726981 25.47593066718644 -13.999999999999998 0.2976002222300084 7.018657495856734 0.229451793837631 0.9996444718105287 0.006337479043208159 16.433781091310205 0.17318380294518387 60.82141284074058 0.02962391841685959 1.0000000000000041e-14 13.999999999999998 -6.789205702019102 LVVLGIRPIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVVLGIRPIR 10 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 61173000.0 23228000.0 11413000.0 26532000.0 False True 22490639.854364395 15970270.418008734 19582473.257061377 1.0 0.7100851963938074 0.8706943592474682 24.422821370306682 -10.242236467543718 4.963624520770279 1.0000363210580674 0.7903897778204549 0.6942859670047012 0.06556841616847423 2.6359045135256497e-05 4.023999100722919e-06 0.06349733575705728 0.02116211532138407 5.724842360906394e-11 10.242236467543718 -0.20964654323761245 LVVLGIRPIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVVLGIRPIR 10 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 61681000.0 14033000.0 23682000.0 23966000.0 False True 21289086.949720506 19455762.071689468 19229109.595329046 1.0 0.9138842881162123 0.9032378720958485 24.3436107407581 -13.999999998668807 0.294827389226247 1.7626218928783848 0.9004752569081722 0.9996382518019937 0.0008239749641751533 16.25942921975649 0.1723049058444056 7.541814315806224 0.0039352353408324235 1.000000003065185e-14 13.999999998668807 -0.8621466359702126 LVVLGIRPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVVLGIRPIR 10 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 80431200.0 35597000.0 19201200.0 25633000.0 False True 48758172.87275404 18352827.494122684 19579013.32820614 1.0 0.37640515246579725 0.40155346631429767 25.53914072870933 -10.38714776956509 5.883078041678406 1.0001515648231405 0.3889793093900593 0.9987311335949299 0.010266756136701253 2.0414754108637255e-05 2.1266367611656296e-06 0.009943167387827679 0.0033135812947510646 4.1006455396333404e-11 10.38714776956509 -0.6111722554330812 LVVLGIRPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVVLGIRPIR 10 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 40855700.0 23228000.0 8796800.0 8830900.0 False True 19315111.174875006 8749409.89237192 10677400.360531747 1.0 0.4529826317413646 0.5528003573917221 24.20322664574096 -9.876867132443943 5.514737464029002 1.0000003181766408 0.5028914945641404 0.9706481121625247 0.040750415863805504 1.5941519394463448e-07 3.2410601587717655e-08 0.039456445774982356 0.013152140164648383 1.3278006213962923e-10 9.876867132443943 -0.4971088236125004 LVVLGIRPIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVVLGIRPIR 10 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 86397000.0 14033000.0 44337000.0 28027000.0 False True 18165995.13178474 41869606.974644646 22926373.58130485 1.0 2.3048342064886986 1.262048867402312 24.114737062850548 -6.590237658554621 2.227475108021478 1.8830098489506621 1.2650697811500844 0.0 0.5653955960117435 0.669018890790868 6.258057936147867 0.21184241828528502 0.6303280618404327 2.568989572333839e-07 6.590237658554621 -0.6179400678005778 LVVNLLQLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVVNLLQLSK 10 0 Q13315 Q13315 ATM Serine-protein kinase ATM 0 3176630.0 685630.0 1179300.0 1311700.0 False True 898867.5696503641 1003353.0368753971 1175977.8667148673 1.0 1.1162412247954112 1.308288235576562 19.777749053266415 -6.963602350001121 0.38128327397168266 0.986997085216527 1.444337459048018 0.9998813643956487 0.001384579909342417 0.07843854220669186 0.016552624053375646 0.002496102665457654 0.016217882154349033 1.0874208354118537e-07 6.963602350001121 0.45734037383149106 LVVNLLQLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVVNLLQLSK 10 0 Q13315 Q13315 ATM Serine-protein kinase ATM 0 9008230.0 685630.0 1353000.0 6969600.0 False True 939125.9394540646 1293219.9862273198 5323524.023417689 1.0 1.3770463916470013 5.668594380975543 19.840959114789307 -6.924170103107788 0.793175878145579 0.9187684384742624 6.431707069954804 0.9952632182141473 0.145737340641154 0.09578003654506198 0.09334929198808475 0.12842525745817449 0.40147540683874533 1.1907755174367832e-07 6.924170103107788 5.512938631480542 up LVVPASQCGSLIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVVPASQCGSLIGK 14 0 Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;F8VXH9;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;H3BND9;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2;PCBP3 Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 0 36304200.0 3889200.0 18069000.0 14346000.0 False True 5098778.86306638 15373175.632410351 12861613.536549127 1.0 3.0150700874218734 2.5224889884348145 22.281720338144595 -10.020967205873957 5.099193504188825 0.9999825333616328 2.7687795379342326 0.9450312920584307 0.2010953916122699 4.1162599238880166e-05 7.903463303822602e-06 0.19471174831883764 0.06490325855428142 9.528681135844803e-11 10.020967205873957 1.7687970045725998 LVVPASQCGSLIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVVPASQCGSLIGK 14 0 Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;F8VXH9;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;H3BND9;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2;PCBP3 Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 0 12528800.0 6947500.0 1353900.0 4227400.0 False True 6726955.415369224 1894519.330495226 3120117.12071843 1.0 0.2816310222848773 0.4638230712202773 22.681522265691914 -10.798148407853562 10.63556116520386 1.0044735429103289 0.3727270467596685 0.94049370964413 0.07437959251398554 0.007851854013932468 0.00014901937504800995 0.07167103234168143 0.024005910258696656 1.5916647277137095e-11 10.798148407853562 -0.6317464961506604 LVVPASQCGSLIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVVPASQCGSLIGK 14 0 Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;F8VXH9;E9PFP8;P57721-5;P57721-4;P57721;J3QT27;P57721-2;P57721-3;H3BND9;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2;PCBP3 Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 0 51548200.0 3889200.0 23423000.0 24236000.0 False True 5327142.341678097 22388094.41049702 18511955.95608801 1.0 4.20264617961092 3.475025589471405 22.344930399667486 -9.460111428906089 22.130345702229974 1.0000000000250164 3.8388358844939288 0.9530427110269277 0.297049862030764 0.0 0.0 0.2876172921595899 0.09587243071986329 3.4664789801724144e-10 9.460111428906089 2.8388358844689123 LVVPASQCGSLIGK(ub)GGCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVVPASQCGSLIGKGGCK 18 1 Q15366-3;Q15366-2;F8VZX2;F8W0G4;F8W1G6;F8VXH9;H3BND9;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 1 169215000.0 20907000.0 29028000.0 119280000.0 True False 27064523.638582185 27412566.28233722 97572263.91615386 1.0 1.0128597365467344 3.605172040680533 24.689899659679455 -6.90798918698393 0.9093271783157186 0.914543526902264 3.9261571795929004 0.9901401477132967 0.12164552277707567 0.10576262810925345 0.14609433792289928 0.09861300660659418 0.26856664312612266 1.2359782063103632e-07 6.90798918698393 3.0116136526906363 up LVVPATQCGSLIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVVPATQCGSLIGK 14 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 46934200.0 3507200.0 25316000.0 18111000.0 False True 4597973.163773117 21538951.480995096 16237047.452979308 1.0 4.684444800743496 3.531348895402233 22.132566615066125 -9.512063543657257 14.690648914855384 0.9999973778596614 4.107896848072865 0.9064189511564253 0.47074943209888503 0.0 0.0 0.4558011776877953 0.15193372589593174 3.075646769550812e-10 9.512063543657257 3.1078994702132032 LVVPATQCGSLIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVVPATQCGSLIGK 14 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 18736700.0 11736000.0 2433100.0 4567600.0 False True 11363447.103961606 3404649.5184488804 3371208.534937197 1.0 0.2996141476526016 0.29667129209075144 23.43789720727738 LVVPATQCGSLIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVVPATQCGSLIGK 14 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 63747200.0 3507200.0 29681000.0 30559000.0 False True 4803906.618516255 28369595.278058413 23341593.58236071 1.0 5.905525966868337 4.8588774586900785 22.195776676589016 -10.072068939623474 6.014669507503809 0.999988506944368 5.382201712779381 0.9589716527957897 0.4272924641809432 6.586322281289929e-05 1.015974430231895e-05 0.4137252237360524 0.13790804981096996 8.470929364858733e-11 10.072068939623474 4.382213205835012 LVVPATQCGSLIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVVPATQCGSLIGK 14 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 11300400.0 3823400.0 3473700.0 4003300.0 False True 4949466.670481423 3280385.541372289 3274740.477326783 1.0 0.6627755594226911 0.6616350195582298 22.238841645363863 LVVPATQCGSLIGKGGCK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVVPATQCGSLIGKGGCK 18 1 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 15980700.0 13682000.0 2298700.0 0.0 True False 11377189.215371085 2286316.446843772 0.0 1.0 0.2009561767466131 0.0 23.439640841722493 -9.45563184347593 0.450936557985704 1.200880646250159 7.198291015986273e-23 0.9976720855301952 0.02083861050350959 0.880955140561448 0.20877796578557117 0.3421086638618875 0.04561145274214351 3.5024194542276876e-10 9.45563184347593 -1.200880646250159 LVVVDFSATWCGPCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVVVDFSATWCGPCK 15 0 P10599;P10599-2 P10599 TXN Thioredoxin 0 86107000.0 32117000.0 25269000.0 28721000.0 False True 48723837.06721113 20759549.522401866 23044281.761138532 1.0 0.42606557225297176 0.4729570400900601 25.538124416089993 -10.023200719950838 7.558917809679902 1.0000000227617 0.4495113078733061 0.9945875342342598 0.019143361581832705 7.329919415554834e-09 9.50030865387348e-10 0.018535480977813854 0.006178493383072086 9.479802294970237e-11 10.023200719950838 -0.5504887148883939 LVVVDFSATWCGPCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVVVDFSATWCGPCK 15 0 P10599;P10599-2 P10599 TXN Thioredoxin 0 60832000.0 32117000.0 16249000.0 12466000.0 False True 41576089.62071765 15344728.865981044 10197315.911961544 1.0 0.3690758078973993 0.24526875915911417 25.309250738182442 -13.999999999999982 0.22895181228251474 4.963614703133088 0.18446920683574558 0.999508380438579 0.007327785823890702 13.258840543394912 0.15151198514973002 23.876109036114226 0.06468858288563187 1.0000000000000409e-14 13.999999999999982 -4.7791454962973425 LVVVLCNLKPQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVVVLCNLKPQK 12 1 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 0 262441000.0 87738000.0 69543000.0 105160000.0 False True 115025367.65600069 59167455.476490915 94279051.9659491 1.0 0.514386145267011 0.8196370408300165 26.77737682683883 -10.4416011566705 6.25330418760743 1.0001072979163572 0.6670115930485152 0.6134006266485416 0.1246181562761603 0.00018647600472630535 1.6651556128746878e-05 0.12069960215370532 0.04022033699105348 3.61741923324005e-11 10.4416011566705 -0.333095704867842 LVVVLCNLKPQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVVVLCNLKPQK 12 1 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 0 242203000.0 57118000.0 96400000.0 88685000.0 False True 86652181.88513744 79196666.82336232 71156370.87798363 1.0 0.9139604462394514 0.821172292837422 26.36873274083572 -6.970162356716833 0.2542895471628304 1.0279354957653353 0.704464693357771 0.9999836118992961 0.0002955586754153589 0.076250162096936 0.008841984699335477 0.0020108077252999758 0.008831873930963111 1.0711188031600011e-07 6.970162356716833 -0.3234708024075643 LVVVLCNLKPQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVVVLCNLKPQK 12 1 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 0 240585000.0 87738000.0 66812000.0 86035000.0 False True 120177109.63029744 63860024.92226136 65715304.94644466 1.0 0.5313825995542318 0.5468204814428105 26.84058688836172 -10.316682462012652 9.621372285344906 1.00000012278713 0.5391015405162147 0.9991592608706348 0.006302488889395263 1.6601358717703043e-08 1.1813839415941459e-09 0.0061023602638063095 0.0020341195423571007 4.8230030658095295e-11 10.316682462012652 -0.4608985822709153 LVVVLCNLKPQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVVVLCNLKPQK 12 1 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 0 218585000.0 57118000.0 100810000.0 60657000.0 False True 73940376.96410453 95199834.88088803 49618048.393378146 1.0 1.287521632829979 0.6710548475762569 26.13985906292817 -6.779879264643743 1.5363222410401247 1.162828107209158 0.6661886690272109 0.7669621466154746 0.12158328290859233 0.2507658568010036 1.1690661797406052 0.062331955677505595 0.14709324218670813 1.66004834243001e-07 6.779879264643743 -0.4966394381819471 LVWFDLDLSTKPYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LVWFDLDLSTKPYR 14 1 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 59382000.0 23833000.0 14899000.0 20650000.0 False True 30852288.318664975 14069857.552726422 16891911.88689283 1.0 0.4560393513571069 0.5475092062028211 24.87887416245353 -10.820058636161002 7.328209650156114 1.0239209324968819 0.5017742787799647 0.9753439911482299 0.03734241186974051 0.013152529274519707 0.00032295487985615 0.03258495019890546 0.012052211606560257 1.5133569091370056e-11 10.820058636161002 -0.5221466537169172 LVYLYLMNYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LVYLYLMNYAK 11 0 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 10640400.0 2681900.0 6388200.0 1570300.0 False True 3515996.871556542 5435105.461008564 1407820.4193812285 1.0 1.545822041247274 0.40040434357894705 21.745502356133173 -6.7771239067074145 1.546969919867527 1.3102211726566702 0.39212365690082635 0.7570776209264698 0.2305586914258181 0.25509133633986786 1.2055514713516358 0.11740741573330389 0.2777179447432164 1.670613910577094e-07 6.7771239067074145 -0.9180975157558438 down LVYLYLMNYAK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LVYLYLMNYAK 11 0 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 560969000.0 179474000.0 226587000.0 154908000.0 False True 272275179.3069288 186150779.5176884 124290365.90141164 1.0 0.683686188331715 0.45648805086747296 28.020490230930033 -7.791682135997189 0.1534781325816155 1.3215897847716833 1.3322159795655594e-15 0.9999638544225435 0.0013399675097177893 0.1292483724651761 0.02079498106015914 0.06704039675084897 0.0948282106087448 1.6155405527492916e-08 7.791682135997189 -1.321589784771682 down LVYLYLMNYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVYLYLMNYAK 11 0 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 30170900.0 2681900.0 10240000.0 17249000.0 False True 3673470.905622356 9787562.940848306 13175141.454306092 1.0 2.664391032978688 3.586564802824802 21.808712417656064 -8.792104522914752 0.235122995858272 1.533386060520175e-21 4.341087178187197 0.9993533779293848 0.027217779699584017 0.3245808741126486 0.07248499184580204 0.6624640591993469 0.402183160813107 1.61397007121314e-09 8.792104522914752 4.341087178187197 LVYLYLMNYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LVYLYLMNYAK 11 0 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 53223000.0 21020800.0 16336500.0 15865700.0 False True 17479726.57933579 16248492.031958656 19183144.51529159 1.0 0.9295621392137405 1.0974510629914285 24.05917928236118 -6.792776314589811 1.4856060926573227 0.9607737104425018 1.099365958774849 0.8100753917135429 0.0299987301334556 0.231241694046659 1.0081994906252771 0.015893024482299074 0.03712943727068753 1.611475419442037e-07 6.792776314589811 0.13859224833234718 LVYLYLMNYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LVYLYLMNYAK 11 0 P63010;P63010-2;A0A087X253;P63010-3;A0A087WU93;A0A087WZQ6;A0A087WYD1;K7ERB2;K7EJX1;K7EN71;Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 P63010;Q10567-3 AP2B1;AP1B1 AP-2 complex subunit beta;AP-1 complex subunit beta-1 0 461222000.0 179474000.0 180835000.0 100913000.0 False True 232332630.961443 170771373.28325945 82547869.45481923 1.0 0.735029653719197 0.3553003687567182 27.791616553022482 -6.966004470976862 0.3403749057792588 1.0410086287106204 0.036694815922053 0.9999323762647776 0.0021757614568811185 0.0776217543081673 0.013667291631950277 0.005354280208784493 0.03285818068650037 1.0814228182039492e-07 6.966004470976862 -1.0043138127885674 down LVYVYLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LVYVYLVR 8 0 O00203;O00203-3;Q13367-4;A0A590UJ60;Q13367;A0A2R8Y2A8;A0A590UKC4;A0A5F9UJV3;A0A590UJW5;F5GWU4;A0A590UJ44;A0A590UK69;F5GYB0 O00203 AP3B1;AP3B2 AP-3 complex subunit beta-1;AP-3 complex subunit beta-2 0 6731600.0 2400100.0 1498200.0 2833300.0 False True 2323910.1392483157 2096439.0730097853 2091173.7328219514 1.0 0.9021170989373507 0.8998513744160329 21.148122853140936 LVYVYLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LVYVYLVR 8 0 O00203;O00203-3;Q13367-4;A0A590UJ60;Q13367;A0A2R8Y2A8;A0A590UKC4;A0A5F9UJV3;A0A590UJW5;F5GWU4;A0A590UJ44;A0A590UK69;F5GYB0 O00203 AP3B1;AP3B2 AP-3 complex subunit beta-1;AP-3 complex subunit beta-2 0 37227300.0 6560300.0 14271000.0 16396000.0 False True 9952454.722172838 11724228.550168078 13155323.413377913 1.0 1.178023801911698 1.321816956782479 23.246620972240116 -6.973551269987683 0.15089865318675877 0.834933258009353 1.6686923221483423 0.9999985040557294 0.0001608899618937868 0.07516627331727335 0.004616348484240948 0.007273124141311356 0.017872639369978797 1.0627931094132323e-07 6.973551269987683 0.8337590641389893 LVYVYLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LVYVYLVR 8 0 O00203;O00203-3;Q13367-4;A0A590UJ60;Q13367;A0A2R8Y2A8;A0A590UKC4;A0A5F9UJV3;A0A590UJW5;F5GWU4;A0A590UJ44;A0A590UK69;F5GYB0 O00203 AP3B1;AP3B2 AP-3 complex subunit beta-1;AP-3 complex subunit beta-2 0 8429300.0 1552600.0 2694700.0 4182000.0 False True 2126638.1774373665 2575639.24381874 3194297.7309935708 1.0 1.2111318564413374 1.5020409982683334 21.020143165847802 -6.966630271623415 0.3288732952978029 0.9640891511928094 1.7585910080102933 0.9999429130779479 0.0015550665008111542 0.07741201070151055 0.012932351292283782 0.004262030526771145 0.02539691514441783 1.0798656541761609e-07 6.966630271623415 0.794501856817484 LVYVYLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LVYVYLVR 8 0 O00203;O00203-3;Q13367-4;A0A590UJ60;Q13367;A0A2R8Y2A8;A0A590UKC4;A0A5F9UJV3;A0A590UJW5;F5GWU4;A0A590UJ44;A0A590UK69;F5GYB0 O00203 AP3B1;AP3B2 AP-3 complex subunit beta-1;AP-3 complex subunit beta-2 0 6768000.0 2400100.0 1910700.0 2457200.0 False True 1995789.4924581284 1900406.6798557453 2970989.159190862 1.0 0.9522079793671505 1.4886285204015288 20.928528128575213 -6.885164949804431 1.0505405632237033 0.9677491138299109 1.5306249315825426 0.977619642197011 0.03626213912230207 0.12315474352615088 0.24545564460301988 0.02645302330749623 0.06489969348464819 1.3026719154092775e-07 6.885164949804431 0.5628758177526317 LWACNFCFQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LWACNFCFQR 10 0 A0A2R8YFH5;Q15437;Q5QPE2 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 0 8958000.0 2563300.0 4586100.0 1808600.0 False True 3360511.1230325103 3901871.7564777895 1621463.421316238 1.0 1.161094730422067 0.48250500056462736 21.68024924833528 -6.8440914146506975 1.2633449797629 1.0857032046050032 0.45832743260410463 0.931254628675848 0.07590218516049302 0.16406926255996174 0.5069039521726866 0.047077626920992224 0.10860132752663469 1.4318864697505365e-07 6.8440914146506975 -0.6273757720008986 down LWACNFCFQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LWACNFCFQR 10 0 A0A2R8YFH5;Q15437;Q5QPE2 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 0 18177500.0 4575400.0 6841600.0 6760500.0 False True 5922945.494617537 6460858.945750262 5530158.368587842 1.0 1.090818571878055 0.9336838189062117 22.49788337924456 -6.75001857000457 1.650117077418695 1.0534010313611635 0.9333771997968068 0.6489509913018046 0.03816219718206229 0.29999294175635316 1.6072122941351779 0.018270667129727455 0.04434944584442764 1.7782033741873327e-07 6.75001857000457 -0.1200238315643567 LWADHGVQACFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LWADHGVQACFGR 13 0 P04899-4;P04899;P04899-6;P04899-3;P04899-5;P04899-2 P04899-4 GNAI2 Guanine nucleotide-binding protein G(i) subunit alpha-2 0 33191800.0 9194800.0 13217000.0 10780000.0 False True 12054471.842569852 11245075.119462483 9664589.009061728 1.0 0.9328550654331432 0.8017430489929591 23.523065105960967 -6.9605105589635805 0.4281779972844571 1.005309738675807 0.7242755386844457 0.9997886628013053 0.0011968591267798336 0.07951923314691789 0.020461179480927905 0.0017067727373835022 0.010891036335837786 1.0951899277865517e-07 6.9605105589635805 -0.28103419999136126 LWADHGVQACFGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LWADHGVQACFGR 13 0 P04899-4;P04899;P04899-6;P04899-3;P04899-5;P04899-2 P04899-4 GNAI2 Guanine nucleotide-binding protein G(i) subunit alpha-2 0 10136400.0 2259000.0 4500100.0 3377300.0 False True 2924320.0315471888 4249665.479094173 2762666.0540243685 1.0 1.453214912611933 0.9447208322690684 21.479669774821417 -6.6716554092916205 1.9316535491482096 1.2888779042424763 0.9467685345093881 0.2863109420765104 0.19244369565443742 0.4573435105020941 3.2915412833326894 0.08016252475785868 0.21370132991326724 2.1298282867670315e-07 6.6716554092916205 -0.34210936973308814 LWAHVYAGAPVSSPEYTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LWAHVYAGAPVSSPEYTK 18 0 P61086;P61086-2;D6RDM7 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 0 33938000.0 10063000.0 11453000.0 12422000.0 False True 13192690.450230625 9744257.043444347 11136690.600237932 1.0 0.7386102994081851 0.844156136479595 23.653235474698793 -10.044932765308637 5.585395944042399 1.0000009658736084 0.791383218011542 0.8389436677561815 0.04308890755030298 5.182451564294525e-07 8.860013076880938e-08 0.04172084867555233 0.013906885112336027 9.017107238823286e-11 10.044932765308637 -0.20861774786206644 LWAHVYAGAPVSSPEYTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LWAHVYAGAPVSSPEYTK 18 0 P61086;P61086-2;D6RDM7 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 0 37117900.0 15642000.0 5954900.0 15521000.0 False True 15145453.271997932 8332722.624393263 11455584.479980772 1.0 0.5501798113760936 0.7563711877254099 23.852381419860706 -10.055279762181195 4.797320214798092 1.0000092472932944 0.6532754995451224 0.7903661041362666 0.08417727692427857 9.167861115074765e-06 1.8052917903824195e-06 0.0815066906825747 0.02716809930169648 8.804815050304148e-11 10.055279762181195 -0.346733747748172 LWAHVYAGAPVSSPEYTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LWAHVYAGAPVSSPEYTK 18 0 P61086;P61086-2;D6RDM7 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 0 124537000.0 29246000.0 48567000.0 46724000.0 False True 44368320.16899631 39899839.39429707 37488980.920143254 1.0 0.8992866811797458 0.8449492966456683 25.403026596460595 -13.99999999988037 0.07579060641906511 1.5580542926907328 0.6692484393851752 0.9999034533559649 0.0006311452661004334 12.300797512137752 0.07621386233540355 1.174710610817642 0.16045022253369393 1.0000000002754595e-14 13.99999999988037 -0.8888058533055576 LWAHVYAGAPVSSPEYTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LWAHVYAGAPVSSPEYTK 18 0 P61086;P61086-2;D6RDM7 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 0 41533000.0 10063000.0 13659000.0 17811000.0 False True 13783563.042349752 13055500.21572725 13604408.629059413 1.0 0.9471789098083316 0.987002314804968 23.716445536221684 -10.124951095272463 4.8915236683972605 1.0000017258271596 0.9670906123066333 0.4765891929425654 0.016257837010868904 3.0600273350592974e-07 5.474517154747857e-08 0.01574240847932555 0.0052471943322935435 7.499786576467664e-11 10.124951095272463 -0.032911113520526336 LWAHVYAGAPVSSPEYTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LWAHVYAGAPVSSPEYTK 18 0 P61086;P61086-2;D6RDM7 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 0 30574200.0 15642000.0 8534700.0 6397500.0 False True 13007016.05809346 8488721.877094686 7735187.671302111 1.0 0.6526263855738597 0.5946934820987618 23.632786695294982 -13.999999999999998 0.2520244420039511 3.440686244203626 0.5718440688559506 0.9995465298250749 0.0038113027073953267 14.079138041410587 0.15885399711810919 17.41723099007859 0.0264381032308089 1.0000000000000041e-14 13.999999999999998 -2.8688421753476754 LWAHVYAGAPVSSPEYTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LWAHVYAGAPVSSPEYTK 18 0 P61086;P61086-2;D6RDM7 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 0 120118000.0 29246000.0 52157000.0 38715000.0 False True 37859523.52484686 49254417.10031226 31669267.249445792 1.0 1.3009782615987504 0.8364940786605922 25.174152918553045 -6.731805643858967 1.716857217636828 1.1807627835480974 0.8366884303928177 0.5675489562465335 0.12650667769364282 0.33285123498605734 1.9229371458324311 0.05837581744230498 0.14454879241564464 1.854361304401811e-07 6.731805643858967 -0.3440743531552797 LWALPQCQLLGVFSGHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LWALPQCQLLGVFSGHR 17 0 Q12788;J3KNP2;A0A087WYP7 Q12788 TBL3 Transducin beta-like protein 3 0 22237100.0 6596200.0 5279900.0 10361000.0 False True 10006917.646814393 4337660.592953014 8313143.808612371 1.0 0.43346620268568586 0.8307397044742125 23.254494324653553 -9.885533102374414 6.510528098531895 1.0000000204154165 0.6321029535799434 0.5334595219822988 0.162186227951838 4.805247036827393e-08 8.266685131561651e-09 0.15703614932045057 0.052345379986793956 1.301568104931737e-10 9.885533102374414 -0.3678970668354731 LWALPQCQLLGVFSGHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LWALPQCQLLGVFSGHR 17 0 Q12788;J3KNP2;A0A087WYP7 Q12788 TBL3 Transducin beta-like protein 3 0 23510200.0 6596200.0 8483000.0 8431000.0 False True 8538910.93054076 8010913.592843699 6896644.509365298 1.0 0.9381657283941686 0.8076726136934352 23.025620646746003 -6.958980700493932 0.44956839311963986 1.0042267426976736 0.7364421741789388 0.999730502719218 0.0013160502947982726 0.08006725452025586 0.022491951127047532 0.001743056340360278 0.01079462795396515 1.0990546789689118e-07 6.958980700493932 -0.2677845685187349 LWDCETGK(ub)QLALLK(ub)TNSAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LWDCETGKQLALLKTNSAVR 20 2 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 2 11762500.0 1666500.0 5014200.0 5081800.0 True False 2184797.6384089566 4266100.90519852 4555984.084067709 1.0 1.9526297677185511 2.0853117030030894 21.059068229103207 -10.8870002785815 0.370759884549387 1.2799489068264378e-24 2.1026692334287387 0.9993858128025743 0.011979803320614102 2.609565887663694 0.18207448384249533 2.308786108587269 0.03687915190894954 1.29717843889871e-11 10.8870002785815 2.1026692334287387 LWDCETGK(ub)QLALLK(ub)TNSAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LWDCETGKQLALLKTNSAVR 20 2 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 2 9231600.0 1666500.0 3237800.0 4327300.0 True False 2282650.08546913 3094743.29002721 3305280.863541002 1.0 1.3557677147836606 1.4480015507333885 21.1222782906261 -12.389119113173267 0.21452302786823413 1.1455609582530847e-08 1.5040610082154586 0.9994054329929764 0.004709862876700903 6.292563977497642 0.1354923088474577 2.780304745424757 0.05281409567290365 4.082074126586891e-13 12.389119113173267 1.504060996759849 LWDEASTCAQK(ub)CCAFNDTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LWDEASTCAQKCCAFNDTR 19 1 Q9UJX2-3;Q9UJX2 Q9UJX2-3 CDC23 Cell division cycle protein 23 homolog 1 6212800.0 1736700.0 4476100.0 0.0 True False 2276830.5182267223 3808283.327701148 0.0 1.0 1.6726248603989973 0.0 21.11859547405563 -6.810962411695033 1.4995600753160685 1.3714372079659953 2.9428001014721083e-20 0.8244183750921259 0.2879504461251289 0.21625084386269838 0.9723222530290583 0.15301850578467807 0.34003614650865677 1.545388187516317e-07 6.810962411695033 -1.3714372079659953 LWDEASTCAQK(ub)CCAFNDTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LWDEASTCAQKCCAFNDTR 19 1 Q9UJX2-3;Q9UJX2 Q9UJX2-3 CDC23 Cell division cycle protein 23 homolog 1 35358700.0 4747700.0 11800000.0 18811000.0 True False 7202608.00336265 9694197.806179205 15092997.604845798 1.0 1.3459288360068071 2.0954906330872647 22.78008795813486 -6.958448738707005 0.45677763252891973 0.9774342255756463 2.494038454771039 0.9997082476849091 0.007809990689759381 0.08026008776741655 0.023215131681269784 0.010125339042115362 0.06194433206344243 1.1004017218853353e-07 6.958448738707005 1.5166042291953925 up LWDEASTCAQK(ub)CCAFNDTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LWDEASTCAQKCCAFNDTR 19 1 Q9UJX2-3;Q9UJX2 Q9UJX2-3 CDC23 Cell division cycle protein 23 homolog 1 9242100.0 1736700.0 2468800.0 5036600.0 True False 2378804.922552797 2359720.252770147 3847058.8120330456 1.0 0.9919772026694104 1.6172233273775989 21.181805535578523 -6.903996837997005 0.9356797805878361 0.9767772995007005 1.688445101770073 0.9884511662997688 0.03147354656949009 0.10852245360130008 0.16130336142209525 0.02502614024080334 0.06651967016922927 1.2473925962021444e-07 6.903996837997005 0.7116678022693725 LWDIPNSK(ub)EILTFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LWDIPNSKEILTFK 14 1 Q8TED0;H0Y8P4;Q8TED0-3 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 1 18823920.0 4501400.0 13472000.0 850520.0 True False 5901378.991619602 11462030.113444692 762516.3491639325 1.0 1.9422630083107064 0.12920985929674447 22.492620681749685 -6.765466522594725 1.5917769393440095 1.5435871412735371 0.12070937473669537 0.7129096296246957 0.3966949563906019 0.27383605345937706 1.3685525562897722 0.196520784372825 0.4697792273395975 1.716063987084655e-07 6.765466522594725 -1.4228777665368417 LWDIPNSK(ub)EILTFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LWDIPNSKEILTFK 14 1 Q8TED0;H0Y8P4;Q8TED0-3 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 1 46261000.0 33727000.0 4802300.0 7731700.0 True False 51166324.77397729 3945292.044458842 6203526.106075499 1.0 0.07710720013381497 0.12124236269614883 25.608691273936675 -10.13084285972406 5.2832752800781275 1.0000227676601308 0.09917478141443592 0.998202915362205 0.01801810466817856 4.891803978323008e-06 8.047440894844761e-07 0.01744639977934624 0.005815318275436877 7.398729340099064e-11 10.13084285972406 -0.9008479862456948 LWDIPNSK(ub)EILTFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LWDIPNSKEILTFK 14 1 Q8TED0;H0Y8P4;Q8TED0-3 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 1 45565200.0 33727000.0 4578500.0 7259700.0 True False 43660266.35856223 4323702.450175043 5938509.090812397 1.0 0.09903060175277928 0.13601632756983384 25.379817596029124 -10.13755288686243 5.21883760437582 1.0000278253974961 0.11752346466058969 0.9986843162364271 0.015099359338899766 168792607.29296294 0.636904530530627 56477.56615817147 0.005168912320734349 7.285294513436447e-11 10.13755288686243 -0.8825043607369064 LWDLTTGTTTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LWDLTTGTTTR 11 0 P63244;J3KPE3;H0Y8W2;H0YAF8;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RFZ9;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 82155000.0 13876000.0 28397000.0 39882000.0 False True 18191570.375375163 24160278.290639054 35755393.21515766 1.0 1.3281029505480941 1.9654923944090934 24.116766752279343 -6.960609839356316 0.4267518074500814 0.9737921764433339 2.3441154519000142 0.9997921532260996 0.005778940145612312 0.07948398714066238 0.020331655118151715 0.008286918151127249 0.052964194869438604 1.0949395942833576e-07 6.960609839356316 1.3703232754566803 LWDLVAGK(ub)TR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LWDLVAGKTR 10 1 O43660-2;O43660;H0YA24 O43660-2 PLRG1 Pleiotropic regulator 1 1 14189900.0 4405000.0 3178300.0 6606600.0 True False 5702359.335531365 3001424.8110497617 5404266.58944049 1.0 0.5263478911874078 0.9477246647307087 22.443127523236107 -10.305194941469239 8.283744343727285 1.000000461645243 0.7370362779590584 0.34178707306745315 0.17202634744023096 1.4665335219471264e-06 1.231451660800596e-07 0.16656408506691628 0.055521264895408755 4.9522784831911044e-11 10.305194941469239 -0.26296418368618457 LWDSGPEPTPSWDGPDK(ub)QSLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LWDSGPEPTPSWDGPDKQSLVR 22 1 H0YKX0;Q96EP0-3;Q96EP0;A0A0B4J293;H0YMG4 H0YKX0 RNF31 E3 ubiquitin-protein ligase RNF31 1 23929400.0 3224600.0 4731800.0 15973000.0 True False 3122236.838056801 6621232.416011025 11789192.120271446 1.0 2.120669494160446 3.775880156358905 21.574148546784265 -6.965512926145057 0.34913718208536426 0.8384475195917622 5.113880969666902 0.9999233317812136 0.00998390222147474 0.07778732786550467 0.014248625970174832 0.022770671100087493 0.14235169919398885 1.082647491216187e-07 6.965512926145057 4.27543345007514 LWEAESK(ub)LSFATCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LWEAESKLSFATCK 14 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 6067700.0 3415600.0 1328800.0 1323300.0 True False 3307173.647604915 1859396.7696004563 976688.0318509483 1.0 0.5622313696612358 0.29532408513180874 21.657167367487432 -8.64219738413117 0.2017078973561283 1.3338804180696995 4.7200580113500865e-20 0.9996624373550763 0.005337095746284586 0.22805366403363755 0.055621772945932915 0.1763171135611952 0.12985908489684742 2.2793059062457968e-09 8.64219738413117 -1.3338804180696995 down LWEAGWK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LWEAGWKQR 9 1 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 1 2358370.0 748870.0 1609500.0 0.0 True False 981775.8220673951 1369368.8737818617 0.0 1.0 1.3947877336175223 0.0 19.905034112710368 -6.858955614926176 1.3858849574231906 1.2086255903171135 1.056599446151462e-22 0.9071400523756279 0.1788809793883308 0.166381022237836 0.642423699211171 0.10404441386400351 0.21738119037862186 1.383707787247929e-07 6.858955614926176 -1.2086255903171135 down LWEAGWK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LWEAGWKQR 9 1 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 1 4377600.0 1303000.0 1182300.0 1892300.0 True False 1261636.9782261415 1654398.5556130498 1396649.862216844 1.0 1.3113110856493204 1.1070140510470217 20.266865420172127 -10.25815375866894 3.8858194583539554 0.9997319819605144 1.2091625682549088 0.5829160508354465 0.08340391533895317 29482712.35245112 33.83389271760163 72286.44093141367 0.02855137860241134 5.518820150449449e-11 10.25815375866894 0.20943058629439437 LWEAGWK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LWEAGWKQR 9 1 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 1 3895270.0 748870.0 0.0 3146400.0 True False 1025747.4764508047 0.0 2403285.122142078 1.0 0.0 2.3429598193677257 19.96824417423326 -6.790731981174697 1.4934768798330122 0.4416355877139824 2.3683672950026953 0.8036874048125008 0.42531304854503077 0.23424786477692403 1.0321784175768711 0.22415041478458544 0.5244967660718671 1.6190789215227498e-07 6.790731981174697 1.926731707288713 LWEAGWK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LWEAGWKQR 9 1 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 1 5547700.0 1303000.0 2189200.0 2055500.0 True False 1083502.232687366 2177406.34507782 2485295.546441813 1.0 2.009600238365258 2.2937613522748697 20.047270695606404 -10.455887906957294 0.2729913236457422 3.082772389258433e-11 2.4126906295731745 0.9990932802890806 0.016716964049371615 2.041462698350835 0.1329179767279362 1.5324442496036963 0.11483944821949595 3.5003550085221655e-11 10.455887906957294 2.4126906295423467 LWEAGWK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LWEAGWKQR 9 1 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 1 18364600.0 3096600.0 0.0 15268000.0 True False 4008609.7431115615 0.0 12489380.662909424 1.0 0.0 3.115638952973986 21.934670540546175 -6.8203367930931185 1.370405081805962 0.46116486984743243 3.1841600284394844 0.8851517391410832 0.4401712500600196 0.19304786099256477 0.712289409815352 0.25239827933812675 0.5816889585015333 1.5123879446299847e-07 6.8203367930931185 2.722995158592052 LWEEQLAAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LWEEQLAAAK 10 0 K7ELL7;P14314-2;P14314 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 19981900.0 1881100.0 8417300.0 9683500.0 False True 2466140.316598312 7161471.650378425 8681544.310691025 1.0 2.903918970943491 3.520296169792145 21.233823456778413 -9.636485431872558 0.31572026621962873 3.757694465445453e-15 3.7225943010564695 0.9986811850988192 0.038956667938115745 1.0035915761641663 0.13151709723662197 1.2242816995547183 0.20416108330469612 2.3094819276971615e-10 9.636485431872558 3.722594301056466 LWEEQLAAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LWEEQLAAAK 10 0 K7ELL7;P14314-2;P14314 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 22841000.0 1881100.0 12681000.0 8278900.0 False True 2576593.5048160697 12120711.489540756 6323594.329297622 1.0 4.704161314885405 2.454246010275894 21.297033518301305 -9.947038242485078 8.247125593024107 0.9999999946596679 3.5792036625806496 0.63665111406443 0.9185240767953147 9.059649834943658e-08 1.2855343062458428e-08 0.8893571065034632 0.2964523710432329 1.1296964330929727e-10 9.947038242485078 2.5792036679209818 LWEQLVHFHVMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LWEQLVHFHVMR 12 0 D6REN3;E2QRC7;D6RB92;H7C465;Q5JS54-3;Q5JS54;Q5JS54-2 D6REN3 PSMG4 Proteasome assembly chaperone 4 0 7588000.0 1197000.0 2652500.0 3738500.0 False True 1569278.5917644883 2256757.3393640164 3351675.8822242366 1.0 1.4380858511722452 2.135806796711367 20.58167006393646 -6.964242315519226 0.370832213841663 0.9468484092767551 2.6513623970244966 0.9998966562616096 0.004754669079216735 0.078219095123195 0.015772731190110703 0.009185013725995823 0.0592305960091575 1.0858196192327293e-07 6.964242315519226 1.7045139877477415 LWEQLVHFHVMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LWEQLVHFHVMR 12 0 D6REN3;E2QRC7;D6RB92;H7C465;Q5JS54-3;Q5JS54;Q5JS54-2 D6REN3 PSMG4 Proteasome assembly chaperone 4 0 10747700.0 3586100.0 3552000.0 3609600.0 False True 3472261.2184318984 4970332.123435295 2664137.4743211507 1.0 1.431439575182635 0.7672629755443046 21.727444055228798 -6.731388733443627 1.7183208945543762 1.2592358369417054 0.7675674035090927 0.5656506850321871 0.18134735680125563 0.33362776717147413 1.93051417404861 0.08361581181691893 0.20714931485185178 1.8561422935022766e-07 6.731388733443627 -0.4916684334326127 LWEQLVHFHVMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LWEQLVHFHVMR 12 0 D6REN3;E2QRC7;D6RB92;H7C465;Q5JS54-3;Q5JS54;Q5JS54-2 D6REN3 PSMG4 Proteasome assembly chaperone 4 0 47427000.0 12929000.0 12785000.0 21713000.0 False True 19614238.236509394 10503416.860339066 17421416.032854028 1.0 0.5354996066473945 0.8882025303652268 24.225397970375926 -10.36326116232821 6.067167524612998 1.0000394835156665 0.7118510685063111 0.4708791831664255 0.14399036564941187 7.691244686159205e-05 8.071739944474018e-06 0.1394371326529521 0.04647269068120729 4.33250265645498e-11 10.36326116232821 -0.28818841500935544 LWEQLVHFHVMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LWEQLVHFHVMR 12 0 D6REN3;E2QRC7;D6RB92;H7C465;Q5JS54-3;Q5JS54;Q5JS54-2 D6REN3 PSMG4 Proteasome assembly chaperone 4 0 15698000.0 1197000.0 4309000.0 10192000.0 False True 1639563.2477086992 4118614.132042513 7784859.510828894 1.0 2.51201906227058 4.748130041160832 20.644880125459352 -6.965491689144305 0.3495108968526796 0.7826871272922157 6.552859741711069 0.9999229252429095 0.013516984523844177 0.07779450204673354 0.014273844295236154 0.030732471930820942 0.19226239600138822 1.0827004339744099e-07 6.965491689144305 5.770172614418853 LWEQLVHFHVMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LWEQLVHFHVMR 12 0 D6REN3;E2QRC7;D6RB92;H7C465;Q5JS54-3;Q5JS54;Q5JS54-2 D6REN3 PSMG4 Proteasome assembly chaperone 4 0 11051000.0 3586100.0 3721000.0 3743900.0 False True 2982001.0411666622 3700954.234439326 4526732.180162245 1.0 1.241097566146853 1.518018309742518 21.507849330663074 -6.969313581367999 0.2740841310173516 0.9344800658752797 1.8330066751963547 0.9999765224907489 0.0010254972325212273 0.0765260515048094 0.009824524781289734 0.005295795597541777 0.025613326544486146 1.0732142205631061e-07 6.969313581367999 0.8985266093210751 LWEQLVHFHVMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LWEQLVHFHVMR 12 0 D6REN3;E2QRC7;D6RB92;H7C465;Q5JS54-3;Q5JS54;Q5JS54-2 D6REN3 PSMG4 Proteasome assembly chaperone 4 0 55975000.0 12929000.0 24208000.0 18838000.0 False True 16736845.368691288 22860803.51945776 15409677.29420278 1.0 1.3658967992990023 0.920703809753111 23.996524292468376 -6.688330645220149 1.8724317662609167 1.2297519243864603 0.9222757393345447 0.362608501617283 0.15480133174292793 0.4202534802147359 2.8553825193978275 0.06617174903645698 0.1726739268654678 2.0496011438796705e-07 6.688330645220149 -0.30747618505191565 LWEYLLELLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LWEYLLELLR 10 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 692610000.0 267040000.0 193000000.0 232570000.0 False True 405119203.2390336 158557642.08411723 186602437.560948 1.0 0.39138515482951086 0.46061118818612623 28.593771231585844 -10.354906026271497 5.80839974564754 1.0001027897010333 0.4259981715098686 0.9892090002242737 0.0282614097734375 3.7625197050518595e-05 4.178656210278465e-06 0.027368840402644482 0.0091213307827382 4.416660058116728e-11 10.354906026271497 -0.5741046181911647 LWEYLLELLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LWEYLLELLR 10 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 530700000.0 267040000.0 113360000.0 150300000.0 False True 345688544.14535683 107051416.34855124 122946942.20823227 1.0 0.30967591539145056 0.3556581329942335 28.364897553678293 -9.861552036273658 6.776706723404404 1.000000012865143 0.33266702419282373 0.9964517661160318 0.01877216172813956 3.65280455603699e-09 5.995047552573357e-10 0.018176067978008144 0.006058689145439958 1.3754599956073713e-10 9.861552036273658 -0.6673329886723192 LWGDIYFNPK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LWGDIYFNPKTR 12 1 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 1 11514100.0 9182900.0 0.0 2331200.0 True False 8891393.865965337 0.0 1720588.7854990764 1.0 0.0 0.1935117048503702 23.083978171268495 -10.357417973713401 5.324955371597005 1.0003420460218442 0.09675585242515587 0.9667212728674259 0.07900082269001447 0.0003209153964703621 3.87258794309425e-05 0.07651981845099841 0.025497405884577693 4.3911879527588324e-11 10.357417973713401 -0.9035861935966883 LWGDIYFNPK(ub)TR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LWGDIYFNPKTR 12 1 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 1 11558500.0 4995000.0 4953200.0 1610300.0 True False 6841786.484799457 4734351.2459579855 1229980.3051695225 1.0 0.6919758832691425 0.17977472812140455 22.70594165119563 -7.286759191440205 0.4770060247895324 1.0147069599970666 4.8754852484488004e-20 0.9988950615213962 0.011245169527754539 0.09886594779310766 0.04261514462538687 0.013234738719604998 0.05415922390247342 5.167027923575593e-08 7.286759191440205 -1.0147069599970666 down LWGDIYFNPK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LWGDIYFNPKTR 12 1 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 1 20176500.0 9182900.0 9707400.0 1286200.0 True False 7635988.221446516 9655104.309431955 1555138.4732831211 1.0 1.2644210584707987 0.20365909796918533 22.86438344670277 -6.84069989486791 1.2790798067327003 1.14065666441435 0.16826971991195158 0.9256633725983824 0.12291979841887013 0.16797993273142517 0.5335336929268766 0.07534512241396212 0.17362033531630192 1.443112223007226e-07 6.84069989486791 -0.9723869445023985 down LWGDIYFNPK(ub)TR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LWGDIYFNPKTR 12 1 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 1 40639900.0 27717000.0 8161400.0 4761500.0 True False 35880202.88375096 7707210.915552821 3894955.8571157507 1.0 0.21480399485263724 0.10855445465944275 25.096684712176454 -13.999999999999998 0.28185800096552094 7.465251010645172 0.0771501475292309 0.9996092967738374 0.007858285258749957 15.499649306771698 0.16820769547947537 57.8278623853723 0.04166209375464569 1.0000000000000041e-14 13.999999999999998 -7.388100863115941 LWGVIDVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LWGVIDVK 8 0 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 7852000.0 2473900.0 2313000.0 3065100.0 False True 3243306.857281681 1967909.4160033823 2747952.8545153146 1.0 0.6067601687410946 0.8472688448660888 21.629034096520712 -10.366126782875165 5.804227189572385 1.0000571472593012 0.7270145068035911 0.6320466523694029 0.09818725586975782 7.262518600589549e-05 7.93123461292352e-06 0.09508924843375668 0.03168980056611456 4.304009459084816e-11 10.366126782875165 -0.27304264045571003 LWGVIDVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LWGVIDVK 8 0 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 19867300.0 3545600.0 12339000.0 3982700.0 False True 5378934.4180808775 10137009.044952974 3195517.5993205807 1.0 1.8845756904709958 0.5940800446607217 22.35888896849771 -6.7222321291919895 1.7515200097529713 1.5368810792766345 0.5958659215667111 0.522950696953948 0.3721335693974313 0.3509848934363637 2.105560182612117 0.16863012104948114 0.4221795539153078 1.8956924080586653e-07 6.7222321291919895 -0.9410151577099234 LWGVIDVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LWGVIDVK 8 0 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 8288600.0 2473900.0 2526300.0 3288400.0 False True 3388567.6846337146 2414679.7126430734 2511747.646723873 1.0 0.7125959807717658 0.7412416927995874 21.692244158043604 -9.94815963725855 5.673522809900837 1.0000002942059816 0.7269188369982138 0.991814829655537 0.011694562965465243 4.352157424330627e-08 8.059482865204824e-09 0.011323224218229105 0.0037744039670580824 1.1267831989105145e-10 9.94815963725855 -0.2730814572077678 LWGVIDVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LWGVIDVK 8 0 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 23736800.0 3545600.0 11449000.0 8742200.0 False True 4589849.09422475 10811853.085520158 7151209.302546954 1.0 2.355600993314648 1.5580488934908723 22.13001529059016 -10.291260587857812 5.446049404583774 0.9998678696349457 1.956824943402797 0.6574224273106095 0.32559928130905047 0.0005224303235719725 6.798772517558007e-05 0.3153028038535866 0.10508671617056922 5.1137490537236356e-11 10.291260587857812 0.9569570737678512 LWHLFQNSATAVAQLYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LWHLFQNSATAVAQLYK 17 0 Q14CZ0;A0A087X1J2 Q14CZ0 C16orf72 UPF0472 protein C16orf72 0 5329700.0 0.0 2297600.0 3032100.0 False True 0.0 3215043.6618257123 2237902.0489497893 0.0 LWHLFQNSATAVAQLYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LWHLFQNSATAVAQLYK 17 0 Q14CZ0;A0A087X1J2 Q14CZ0 C16orf72 UPF0472 protein C16orf72 0 4906900.0 0.0 2173900.0 2733000.0 False True 0.0 2162188.7692146325 3304457.6640357445 0.0 LWIANYSLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LWIANYSLPR 10 0 O43172-2;O43172 O43172-2 PRPF4 U4/U6 small nuclear ribonucleoprotein Prp4 0 9395300.0 3291800.0 3192200.0 2911300.0 False True 4315581.677836543 2715936.2030981444 2610066.603161541 1.0 0.6293325919530918 0.6048006498326782 22.0411235962076 -13.999999999999998 0.3858605684062755 6.708018813356267 0.6028629560774685 0.9998167938419696 0.002447108133425209 24.792451979778345 0.2031694986918421 117.83507274062684 0.006534527534541109 1.0000000000000041e-14 13.999999999999998 -6.105155857278798 LWIANYSLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LWIANYSLPR 10 0 O43172-2;O43172 O43172-2 PRPF4 U4/U6 small nuclear ribonucleoprotein Prp4 0 6382000.0 2536400.0 1051300.0 2794300.0 False True 2455883.3703551684 1471089.5724570735 2062389.002796873 1.0 0.5990062843433503 0.8397748149166431 21.227810618222207 -10.298528224480735 5.744809273102574 1.00002619875975 0.7193905496299947 0.6442681318851393 0.09829334100405025 3.2985502644660943e-05 4.027564303050488e-06 0.09518099209587406 0.031724039395980064 5.028885824272624e-11 10.298528224480735 -0.28063564912975536 LWIANYSLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LWIANYSLPR 10 0 O43172-2;O43172 O43172-2 PRPF4 U4/U6 small nuclear ribonucleoprotein Prp4 0 9548000.0 3291800.0 3475400.0 2780800.0 False True 4508867.417550121 3321845.3363890755 2124032.3123737224 1.0 0.7367360866410194 0.47107890201123026 22.104333657730493 -6.971013102690456 0.23272865015993083 1.104420411258985 0.09577901809181785 0.9999892395986157 0.0007082988819316394 0.07597538905720548 0.007844371342874521 0.006690783861225759 0.026247248021324943 1.0690226262596443e-07 6.971013102690456 -1.0086413931671672 down LWISVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LWISVAR 7 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 15993400.0 5429500.0 5989700.0 4574200.0 False True 7118127.079352785 5096060.107667731 4100905.6628246927 1.0 0.7159271042588762 0.5761214455864375 22.763066258720833 -13.999999998421554 0.09277725453870611 2.4379814106172923 0.24196234771475644 0.9998292294584286 0.002304611739150166 12.139222895129818 0.08916858828664388 3.4114493989138057 0.2995186029645813 1.0000000036345058e-14 13.999999998421554 -2.196019062902536 LWISVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LWISVAR 7 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 9290200.0 3657000.0 2472600.0 3160600.0 False True 3540910.536740595 3459922.074438658 2332744.044032424 1.0 0.9771277863528044 0.6587977922141216 21.75568896294536 -6.921367252927068 0.8145317996584528 1.006683690524053 0.6058160773450099 0.9945521344170237 0.011494628651666736 0.09737404055482508 0.10149772232464122 0.009976158658123156 0.03028489426420974 1.1984853979712484e-07 6.921367252927068 -0.4008676131790432 LWISVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LWISVAR 7 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 21341000.0 5429500.0 7544800.0 8366700.0 False True 7436932.876720449 7211445.788682827 6390657.77759538 1.0 0.9696800963817415 0.8593136288213405 22.826276320243725 -6.947043131845757 0.5904161750725327 1.0012740983903186 0.8221621858650351 0.9989483153745402 0.001960511735926335 0.0846952924400062 0.041047277527023536 0.0020316630156217265 0.009247111262268723 1.129683714851187e-07 6.947043131845757 -0.17911191252528347 LWISVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LWISVAR 7 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 8755700.0 3657000.0 2613600.0 2485100.0 False True 3040957.5325692203 2599520.0180410156 3004722.9201958366 1.0 0.8548360147090754 0.9880844727408047 21.536094238379636 -10.402753663316407 6.594636818218742 1.0000090462142237 0.9214602437271142 0.3165788320084474 0.05439845519839926 7.2360112995344594e-06 6.553281031751099e-07 0.05267714362587031 0.017557025920234233 3.955909400458348e-11 10.402753663316407 -0.07854880248710949 LWK(ub)AAVELEEPEDAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LWKAAVELEEPEDAR 15 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 1 22081000.0 1959200.0 4770800.0 15351000.0 True False 2536223.0216056923 4505300.786129756 12557275.514561344 1.0 1.7763819458106775 4.951171646810179 21.27425018310495 -6.9443680048495935 0.6175905192447835 0.9651878941091973 5.929866787262173 0.9986818699574699 0.06205612911084956 0.08582920189773685 0.04595104859841774 0.06263337357538237 0.26844157418776476 1.1366637114503044e-07 6.9443680048495935 4.964678893152976 LWK(ub)SGFSLDNGELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LWKSGFSLDNGELR 14 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 31251000.0 7538900.0 14007000.0 9705100.0 True False 11437062.467415929 11507341.412809499 7786882.731103552 1.0 1.0061448423136443 0.6808463933189399 23.447213217386306 -6.902595186645446 0.9447080241196251 1.0125786106847294 0.6448416864374782 0.9878140034259446 0.016770425419686666 0.10952038723942553 0.1668388981173949 0.013246152453658335 0.03493567508620504 1.2514249614666582e-07 6.902595186645446 -0.36773692424725124 LWK(ub)SGFSLDNGELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LWKSGFSLDNGELR 14 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 34680700.0 7538900.0 19803000.0 7338800.0 True False 9759254.663935853 18700945.641763944 6003213.7024469385 1.0 1.9162268314270996 0.615130346442448 23.218339539478755 -6.7175030796178685 1.768660244613142 1.5589117052902126 0.6174845994993736 0.5005683637538629 0.38567411260869205 0.36017912906162586 2.20062983623884 0.17324897204273781 0.4361429895558127 1.9164474730006479e-07 6.7175030796178685 -0.941427105790839 LWLDAYLHK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 LWLDAYLHK 9 0 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 8842480.0 661810.0 959870.0 7220800.0 True False 640801.2038064788 1343151.0966559234 5329455.860643336 1.0 2.096049583985416 8.3168630598466 19.28951733242689 -6.937022242991742 0.6867066006838296 0.9252843774214565 9.857000769929925 0.9977472857637383 0.1529289415745693 0.08915178484302391 0.060995047353164536 0.14569847368789302 0.5428091181726821 1.1560530318230658e-07 6.937022242991742 8.931716392508468 LWLDAYLHK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LWLDAYLHK 9 0 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 8134410.0 661810.0 1674200.0 5798400.0 True False 550324.338154125 1665180.7522973188 7010818.631227528 1.0 3.025817026160607 12.739430450673732 19.069922607861166 -6.940744524499759 0.6526076092144701 0.8922099252238674 15.417203421796836 0.9982597013651096 0.2137455958944988 0.08742884841141986 0.05307671593272116 0.20925677449456728 0.833328292768281 1.1461869923424504e-07 6.940744524499759 14.52499349657297 LWLK(ub)NVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LWLKNVSR 8 1 Q96EK4 Q96EK4 THAP11 THAP domain-containing protein 11 1 5528200.0 1202400.0 2634800.0 1691000.0 True False 1164230.470160484 3686889.380300484 1248076.3710873977 1.0 3.1668037169584324 1.072018301423906 20.150945250632994 -6.638261826865461 2.050408717680053 2.4188028934870505 1.0806398240685404 0.1480902898239389 0.9275088737993185 0.5377703406333336 4.318743503846763 0.3686176460965243 1.0272674874212664 2.3000547454617084e-07 6.638261826865461 -1.33816306941851 LWLK(ub)NVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LWLKNVSR 8 1 Q96EK4 Q96EK4 THAP11 THAP domain-containing protein 11 1 1931350.0 559160.0 943830.0 428360.0 True False 765896.5627308235 902128.4697715667 327190.19035112514 1.0 1.1778724617264307 0.42719892773055446 19.5467900382427 -6.844205193286109 1.2625866499615976 1.0946446974849033 0.40036100899645904 0.9314533384326653 0.08385552050780035 0.16395550774072729 0.5058570061172759 0.052035892100664845 0.12006030586303343 1.4315113861236486e-07 6.844205193286109 -0.6942836884884442 down LWMMK(ub)GQIEEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LWMMKGQIEEQK 12 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 1 4738400.0 1621800.0 1637900.0 1478700.0 True False 1570316.8467284369 2291922.0115356604 1091384.109950879 1.0 1.4595283851858303 0.6950088526558472 20.58262425397248 -6.7439150139044335 1.6721436085163068 1.272163688158869 0.6941455909445948 0.6225029958750434 0.19306663996903303 0.3107656862677791 1.7075112203586076 0.09128329820300103 0.22306463114556233 1.8033706038089077e-07 6.7439150139044335 -0.5780180972142741 LWMMK(ub)GQIEEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LWMMKGQIEEQK 12 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 1 19893300.0 3351900.0 4077400.0 12464000.0 True False 5085077.356714044 3349756.1131283906 10000484.93683473 1.0 0.6587424100255949 1.966633786530438 22.277838290565033 -6.837385828961992 1.2944111486041825 0.8183506345734195 2.0074914368814447 0.919879731698696 0.15678913955079718 0.1718713978949639 0.5605010195986931 0.0950174963350972 0.21878087676209623 1.4541666190881751e-07 6.837385828961992 1.1891408023080252 LWMMK(ub)GQIEEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LWMMKGQIEEQK 12 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 1 5711100.0 1731400.0 2031000.0 1948700.0 True False 2371545.3693256816 1941263.7043811437 1488457.1947362893 1.0 0.8185648604872008 0.6276317602810664 21.17739603777327 -6.970480666777443 0.2464380923754943 1.0633111490573453 0.37731847399277607 0.9999858905465424 0.0005710537587713859 0.07614708163406772 0.008470336487368602 0.004363403562807811 0.0184075889218108 1.0703340292579949e-07 6.970480666777443 -0.6859926750645692 LWMMK(ub)GQIEEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LWMMKGQIEEQK 12 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 1 5273500.0 1621800.0 2173800.0 1477900.0 True False 1348598.5579220012 2162089.307934485 1786922.0569624698 1.0 1.6032119382256773 1.325021479865634 20.363029529406756 -10.006945119120441 4.410928996670209 0.9999810441165281 1.4641167089528981 0.7877376676787833 0.11357077931517613 78945906.90768352 139193247.04496884 21518.31594631223 0.041562644934106795 9.841354610304759e-11 10.006945119120441 0.46413566483637003 LWMMK(ub)GQIEEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LWMMKGQIEEQK 12 1 O94906-2;O94906 O94906-2 PRPF6 Pre-mRNA-processing factor 6 1 20686100.0 3351900.0 4866200.0 12468000.0 True False 4339100.625826928 4595391.692266413 10198951.932483286 1.0 1.0590654811999531 2.350476011498261 22.048964612657482 -6.916460201618683 0.850562085067912 0.9677113853999666 2.5426702774946204 0.9931399013587342 0.05161411276811717 0.10029966345046315 0.1167361423194683 0.04365652213699323 0.1266572350565151 1.2121037598554493e-07 6.916460201618683 1.5749588920946538 up LWNTK(ub)HHPEDVEPALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LWNTKHHPEDVEPALR 16 1 P14550;Q5T621;V9GYG2;V9GYP9 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 1 7863300.0 2135800.0 2903900.0 2823600.0 True False 2800054.483116619 2470649.439313541 2531440.957883741 1.0 0.8823576306142332 0.9040684647914793 21.417023468550642 -10.91662024638066 10.840987904240231 1.0133229160539012 0.8932130477028563 0.969931004066949 0.008863410937405116 0.0028924548558101424 2.224628860315646e-05 0.008697252219132557 0.002860653579263556 1.2116571616927381e-11 10.91662024638066 -0.12010986835104498 LWNTLGVCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LWNTLGVCK 9 0 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RBD0;D6RFZ9;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 59545000.0 15291000.0 19100000.0 25154000.0 False True 20046649.07825465 16250354.451216891 22551305.37420583 1.0 0.810626972507054 1.1249413947525062 24.256857765619493 -6.743586348909083 1.6737930730497654 0.8877939511135203 1.125265611825119 0.620858139190488 0.0795627985865231 0.3113550551112787 1.714088880319755 0.03758606570944274 0.09186414082137061 1.8047358735641414e-07 6.743586348909083 0.23747166071159864 LWNTLGVCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LWNTLGVCK 9 0 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RBD0;D6RFZ9;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 69743000.0 14728000.0 40231000.0 14784000.0 False True 22343452.761026386 33051463.72376232 11861935.919942614 1.0 1.4792460268904313 0.5308909078114082 24.41334880868579 -6.769331123282091 1.5771813940848958 1.2751162036160775 0.525711052896389 0.7279532142543289 0.20194143443419268 0.2675029797197087 1.3131443230743836 0.10093379661865047 0.24039568789124588 1.7008612100748372e-07 6.769331123282091 -0.7494051507196885 LWNTLGVCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LWNTLGVCK 9 0 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RBD0;D6RFZ9;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 55371000.0 15291000.0 22940000.0 17140000.0 False True 20944495.92373747 21926434.947564427 13091885.009380616 1.0 1.046882915081956 0.6250752014777741 24.320067827142385 -6.879310978166626 1.0835901061442523 1.0288036319517706 0.5955688354672428 0.9731273317000853 0.030943948647948534 0.1282442812021903 0.2759643221357678 0.022010778317036326 0.05313774859073207 1.3203498542262103e-07 6.879310978166626 -0.4332347964845278 LWNTLGVCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LWNTLGVCK 9 0 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RBD0;D6RFZ9;E9PD14;D6RAU2 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 16466000.0 7668200.0 1942300.0 6855500.0 False True 6376448.058858974 1931836.4443836357 8288953.353749375 1.0 0.3029643504583531 1.2999327019112632 22.604321577194334 -6.718725581987717 1.763735429801192 0.5753629562105012 1.2982868023927248 0.5065829719295569 0.29336143694538497 0.35779358650589116 2.1744593570328004 0.13209903053204383 0.33213684403193067 1.9110604204641098e-07 6.718725581987717 0.7229238461822236 LWNTLGVCK(ub)YTVQDESHSEWVSCVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LWNTLGVCKYTVQDESHSEWVSCVR 25 1 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RBD0;D6RFZ9 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 180088000.0 58465000.0 12763000.0 108860000.0 True False 88695679.36402823 10485342.932225863 87343773.28496699 1.0 0.11821706544680168 0.9847579263301801 26.402360492391647 -9.375174149383458 12.727645375295024 0.9999998057466037 0.5514874958887932 0.26318816120111976 0.3537638250727412 0.0 0.0 0.3425303507493321 0.11417678358311067 4.215274396550872e-10 9.375174149383458 -0.44851230985781054 LWNTLGVCK(ub)YTVQDESHSEWVSCVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LWNTLGVCKYTVQDESHSEWVSCVR 25 1 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RBD0;D6RFZ9 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 163750000.0 58465000.0 17234000.0 88051000.0 True False 75684095.01744415 16274912.75009647 72026621.47955461 1.0 0.21503742293998926 0.9516744761624415 26.173486814484097 -9.200420040172208 11.01888488931666 1.000001904253017 0.5833559495512128 0.299004254157344 0.3007308176724235 0.0 0.0 0.29118136213324625 0.09706045404441539 6.303473912811623e-10 9.200420040172208 -0.4166459547018042 LWSK(ub)YNADQIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LWSKYNADQIR 11 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 8278700.0 1963300.0 2186900.0 4128500.0 True False 1900976.1161560877 3060140.5745328413 3047121.9976548334 1.0 1.6097732888515552 1.6029249245994401 20.8583089754192 -10.128534763095042 4.608048813158455 0.9999415672700469 1.6063491067366154 0.9999043357220391 0.0027958330369905163 1.679736132719816e-06 3.176689119387456e-07 0.002707313657311333 0.0009023512271414954 7.438155218227538e-11 10.128534763095042 0.6064075394665684 LWSK(ub)YNADQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LWSKYNADQIR 11 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 9559400.0 1345500.0 2779900.0 5434000.0 True False 1842967.7107703052 2657074.8261000197 4150601.116742955 1.0 1.4417370475739058 2.252129048429247 20.813599364156268 -6.961697687679766 0.41080792491247625 0.9604294973495975 2.763550669168516 0.9998280726915157 0.006798783970964363 0.07910016066981423 0.018930987385964493 0.010437692451231198 0.06764407494890638 1.0922003523873093e-07 6.961697687679766 1.8031211718189186 LWSK(ub)YNADQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LWSKYNADQIR 11 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 11369100.0 1963300.0 2975000.0 6430800.0 True False 1632570.9389371485 2958973.084508738 7775450.547340304 1.0 1.8124621809298627 4.762703023736505 20.638714250853475 -6.94709880325225 0.5898355641642778 0.9658830438746305 5.7576922439203795 0.9989534972584007 0.05229806107295142 0.08467206520432133 0.040948041026825366 0.054228493383785846 0.2471445345599743 1.1295389120661075e-07 6.94709880325225 4.791809200045749 LWSSLQTHCCSQNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LWSSLQTHCCSQNK 14 0 X6R5C5;X6R8A1;P10619-2;P10619;Q5JZH0 X6R5C5 CTSA Carboxypeptidase;Lysosomal protective protein;Lysosomal protective protein 32 kDa chain;Lysosomal protective protein 20 kDa chain 0 5133000.0 2618700.0 899100.0 1615200.0 False True 3586904.157706579 859374.7890738966 1233723.0260881884 1.0 0.23958677212701715 0.3439520466242441 21.77430776623692 -10.764579495741788 7.144577829619546 1.0147297225309553 0.2917694093756306 0.9839746378513718 0.042606944897284706 0.009638213891396429 0.00031758782154998075 0.03977490792561313 0.013751332334996732 1.719572552050031e-11 10.764579495741788 -0.7229603131553246 LWTLVSEQTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LWTLVSEQTR 10 0 E9PLL6;P46776;E9PJD9 E9PLL6 RPL27A 60S ribosomal protein L27a 0 48605000.0 12791000.0 18521000.0 17293000.0 False True 16769124.868220195 15757738.994292548 15503686.24616925 1.0 0.9396876174591339 0.9245375872625813 23.99930406502658 -13.999999999999714 0.1940069466424238 1.3279125494267552 0.9140963643080428 0.9994876693281388 0.0007377475813576703 12.418754059671297 0.13967977995413752 1.5416192123049528 0.010096337045196307 1.0000000000006585e-14 13.999999999999714 -0.41381618511871243 LWTLVSEQTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LWTLVSEQTR 10 0 E9PLL6;P46776;E9PJD9 E9PLL6 RPL27A 60S ribosomal protein L27a 0 42128000.0 13929000.0 6031000.0 22168000.0 False True 13486831.51934913 8439209.75124951 16361535.774255121 1.0 0.6257370190427636 1.2131489705926661 23.68504811789181 -6.73460231293581 1.7067734422216363 0.7759323759620993 1.213083846380813 0.5803709648378261 0.1572816186439536 0.32765388434343723 1.8719598807008624 0.07297139365816464 0.18011538285254117 1.8424583836788225e-07 6.73460231293581 0.4371514704187136 LWTLVSEQTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LWTLVSEQTR 10 0 E9PLL6;P46776;E9PJD9 E9PLL6 RPL27A 60S ribosomal protein L27a 0 48644000.0 12791000.0 20018000.0 15835000.0 False True 17520178.363777757 19133538.56932629 12095099.132061962 1.0 1.092085832235823 0.6903525113116473 24.06251412654947 -6.8464063990712365 1.2522213793531811 1.0490310423587395 0.6753653054429051 0.9349183585481048 0.043837468622727374 0.16145935415287027 0.4889985207729824 0.027416154205286505 0.06331708782874008 1.4242741789846202e-07 6.8464063990712365 -0.3736657369158344 LWTLVSEQTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LWTLVSEQTR 10 0 E9PLL6;P46776;E9PJD9 E9PLL6 RPL27A 60S ribosomal protein L27a 0 28274700.0 13929000.0 8123700.0 6222000.0 False True 11582580.659326412 8079936.0156718055 7522991.432722437 1.0 0.6975937619882456 0.6495090907625019 23.465453393326086 -13.999999999566054 0.2588108307223454 3.2001007102948 0.631733242054702 0.999559915654079 0.0032544740162463045 14.364895948496304 0.16098549740020446 16.517359781536538 0.021154510226558936 1.000000000999198e-14 13.999999999566054 -2.5683674682400977 LWYVLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LWYVLLK 7 0 Q9HD33;Q9HD33-2 Q9HD33 MRPL47 39S ribosomal protein L47, mitochondrial 0 8050400.0 2393700.0 2847800.0 2808900.0 False True 3138163.8806237713 2422919.340637457 2518261.9728713804 1.0 0.7720818391918571 0.8024635005265648 21.58148926375565 -10.143535330151702 7.627602204213791 1.00000006238086 0.7872726699184003 0.9849323946397832 0.012403261301346447 1.3161075357064979e-08 1.4780679811891827e-09 0.012009409604284557 0.004003135371564474 7.185627004379294e-11 10.143535330151702 -0.21272739246245975 LWYVLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LWYVLLK 7 0 Q9HD33;Q9HD33-2 Q9HD33 MRPL47 39S ribosomal protein L47, mitochondrial 0 6819700.0 3117300.0 1434800.0 2267600.0 False True 3018343.0178237497 2007723.1223831533 1673647.533458178 1.0 0.6651739416385942 0.5544921579737785 21.525325338738334 -13.999999999999998 0.15470819507580652 2.6318866659468214 0.43907374617346273 0.9995512925990716 0.0040119084560561 11.978581386521274 0.12409787819618376 5.869747988125159 0.10453952735536581 1.0000000000000041e-14 13.999999999999998 -2.192812919773359 LWYVLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LWYVLLK 7 0 Q9HD33;Q9HD33-2 Q9HD33 MRPL47 39S ribosomal protein L47, mitochondrial 0 9433100.0 2393700.0 3052800.0 3986600.0 False True 3278715.5773102026 2917917.2017403985 3045047.186604243 1.0 0.8899574034214348 0.9287317288748611 21.64469932527854 -10.108673685332581 6.474573947433742 1.0000001536156635 0.9093445665831922 0.8793508344846056 0.015829552080251556 3.509885312481218e-08 4.832648588070256e-09 0.015326923818247875 0.005108965965394659 7.786213619301379e-11 10.108673685332581 -0.09065558703247134 LWYVLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LWYVLLK 7 0 Q9HD33;Q9HD33-2 Q9HD33 MRPL47 39S ribosomal protein L47, mitochondrial 0 5811500.0 3117300.0 1345700.0 1348500.0 False True 2592173.069805312 1338450.4469994637 1630465.1152404668 1.0 0.5163430106539875 0.628995468795193 21.30573061417261 -9.873615855998626 6.610672169617413 1.0000000152970547 0.5726692397246022 0.9504608514283389 0.04599017345277078 1.0383005590762106e-08 1.756561083609303e-09 0.044529795626772777 0.014843264655970375 1.3377782907138776e-10 9.873615855998626 -0.4273307755724526 LYAQVK(ub)QK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYAQVKQK 8 1 Q9Y4X5;A0A087WT96 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 13633300.0 4679100.0 6468100.0 2486100.0 True False 6134345.41246886 5503084.692456323 2228862.220355136 1.0 0.8970940373312828 0.36334149293658646 22.548477973429236 -6.9389911786201806 0.6688905728146847 1.0061084790561778 0.2235824418600504 0.9980286462249962 0.012389757973506627 0.08823012087745262 0.056729911925051 0.011970162587551587 0.046147038575230566 1.150823764213639e-07 6.9389911786201806 -0.7825260371961275 down LYAQVK(ub)QK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYAQVKQK 8 1 Q9Y4X5;A0A087WT96 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 15277700.0 7292900.0 6645700.0 1339100.0 True False 7061390.88143164 9299362.666867668 988349.537861109 1.0 1.316930732629589 0.13996527801060193 22.75152094830353 -6.835018502772561 1.305312004349219 1.168854025854518 0.10491682918120523 0.9155425776361706 0.1445097210080363 0.17470313896700135 0.5803532050401952 0.08687414520519603 0.19995418963878048 1.4621148808828313e-07 6.835018502772561 -1.0639371966733127 down LYAQVK(ub)QK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYAQVKQK 8 1 Q9Y4X5;A0A087WT96 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 13061100.0 6190700.0 3903000.0 2967400.0 True False 9391744.500793472 3206479.155721814 2380892.0893423758 1.0 0.34141464937114835 0.25350903542374087 23.16296173027937 -13.999999999999998 0.28382017297512735 6.482080494387905 0.22802710753425137 0.9996136600099581 0.006547617283671557 15.60870968010962 0.16882482922350722 49.78042423151095 0.03415402181631735 1.0000000000000041e-14 13.999999999999998 -6.254053386853653 LYAQVK(ub)QK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYAQVKQK 8 1 Q9Y4X5;A0A087WT96 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 12742800.0 4679100.0 5592300.0 2471400.0 True False 6409089.71792296 5345213.694736913 1887706.2200807058 1.0 0.8340051286517447 0.29453577702333494 22.611688034952127 -6.949639218680259 0.5627902460988977 1.006955190483929 0.09567980961079818 0.9991726676875966 0.008662300224054575 0.08363093568161015 0.03656438284527564 0.009254508501515839 0.04487221654689571 1.12295093560951e-07 6.949639218680259 -0.9112753808731308 down LYAQVK(ub)QK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYAQVKQK 8 1 Q9Y4X5;A0A087WT96 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 16974770.0 7292900.0 8700300.0 981570.0 True False 6064369.480249954 8653429.757025668 1186811.7487331016 1.0 1.4269298375053825 0.19570241433973198 22.531926223737806 -6.813067574164004 1.4017272402344998 1.2318372619888087 0.1726423759253958 0.8676674453643098 0.18569121430641558 0.20263951099212582 0.7841436428047496 0.1041506587259773 0.24059015581526133 1.5379153293460022e-07 6.813067574164004 -1.0591948860634128 down LYASYEK(ub)QGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYASYEKQGR 10 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 13437300.0 4632000.0 4515600.0 4289700.0 True False 6072596.856351804 3841890.0816709413 3845842.993707988 1.0 0.6326601571866916 0.6333110997950275 22.533882164982195 -9.961839997353849 5.344945818002172 1.000001036988829 0.6329856284894634 0.9999976396062693 0.00026574621193745465 364903.83274295344 0.05096497669128687 4.657051486658213 9.097199603107482e-05 1.091842518660043e-10 9.961839997353849 -0.36701540849936565 LYASYEK(ub)QGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYASYEKQGR 10 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 20817930.0 4814000.0 7406820.0 8597110.0 True False 4661182.205050378 10364401.852056045 6345268.983228364 1.0 2.2235564704649917 1.361300353449664 22.15226447807849 -10.148509581409842 4.649396148151227 0.9999143846027199 1.7924284119661218 0.5296605643621264 0.35201458574773015 246209447.3675418 39.49919059991784 229593.5785514489 0.12050395573540819 7.103794974294506e-11 10.148509581409842 0.7925140273634019 LYASYEK(ub)QGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYASYEKQGR 10 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 94962800.0 15866500.0 30985000.0 48111300.0 True False 24070640.496525373 25455484.663090035 38602080.46706809 1.0 1.0575325017531032 1.6036997633129184 24.52077119525813 -6.9270572238011985 0.7705522127714609 0.9907262272878948 1.7078652542088735 0.9959279698574821 0.017359673990213872 0.09419417745580465 0.08537474045177527 0.01554716220047104 0.05024174991399311 1.1828856852783425e-07 6.9270572238011985 0.7171390269209786 LYASYEK(ub)QGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYASYEKQGR 10 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 17263980.0 4632000.0 5398800.0 7233180.0 True False 6344575.575093313 5160263.164555839 5524851.856018184 1.0 0.8133346515428567 0.8707992820996425 22.597092226505087 -9.98883050278161 6.2930780996072615 1.0000000684076005 0.8420669668212442 0.9096759716589606 0.02345983718696496 2.251704853541554e-08 3.603651623639079e-09 0.022714899498304117 0.007571629894151507 1.0260522976226566e-10 9.98883050278161 -0.15793310158635632 LYASYEK(ub)QGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYASYEKQGR 10 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 26526730.0 4814000.0 12075900.0 9636830.0 True False 4003054.296359922 12010844.72982152 11651846.597332433 1.0 3.0004201393778955 2.910739084385578 21.932669753512766 -10.10415203681036 4.612881097064356 0.9998574408338401 2.9555796119258244 0.998425193405258 0.03661213755627448 12747844.285670426 5.786600671259975 19519.088455171564 0.012533308485923158 7.867703107429925e-11 10.10415203681036 1.9557221710919843 LYASYEK(ub)QGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYASYEKQGR 10 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 51926700.0 15866500.0 27086700.0 8973500.0 True False 20539497.02547301 25579301.33387709 7340415.07588537 1.0 1.2453713594911178 0.35738046880027363 24.29189751735058 -6.8330027855092945 1.3143658339024058 1.1308634970133438 0.3319728723797346 0.9117626203186385 0.11121982325672848 0.17713284903553445 0.597388893391072 0.06641629805054636 0.1528503400038589 1.4689168561686973e-07 6.8330027855092945 -0.7988906246336092 down LYAVHQEGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYAVHQEGNK 10 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 13366180.0 547780.0 7859500.0 4958900.0 False True 718144.8847090654 6686893.236091044 4445800.597127663 1.0 9.311342848038297 6.1906736255995805 19.453915409522267 -9.086341724581 12.85933384611623 1.0000000000025628 7.751008236671558 0.8618773421118068 1.2740078751638286 0.0 5.892835928178434e-17 1.2335528208616382 0.4111842736205458 8.197063046644509e-10 9.086341724581 6.751008236668994 LYAVHQEGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYAVHQEGNK 10 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 5795600.0 2079600.0 1109300.0 2606700.0 False True 2013584.2363154893 1552249.27492308 1923927.0706762362 1.0 0.7708886705248684 0.955473844092408 20.941334396597956 -9.963359229143327 5.654951242916842 1.0000001879284448 0.8631812574171113 0.422815531379109 0.07535658155436438 1.7852771263203916e-07 3.268497744503047e-08 0.07296379637270474 0.024321232115533706 1.0880297510450182e-10 9.963359229143327 -0.13681893051133354 LYAVHQEGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYAVHQEGNK 10 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 12315180.0 547780.0 5521100.0 6246300.0 False True 750309.0691978874 5277159.546163826 4771052.586586585 1.0 7.033314353784016 6.358783043482394 19.51712547104516 -9.705705872390283 6.4462461768582955 0.9999999741634178 6.696048698639762 0.9895918340941571 0.27537625431848833 1.0315865084327641e-07 1.7257718700362443e-08 0.266631911718687 0.0888773039062426 1.9692194996819057e-10 9.705705872390283 5.696048724476345 LYAVHQEGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYAVHQEGNK 10 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 2495720.0 2079600.0 198230.0 217890.0 False True 1729279.541900725 197162.09564442572 263449.79159046797 1.0 0.11401401038244888 0.15234656121641216 20.721739672032232 -10.260054120446998 5.490160160173796 1.0000750762582091 0.13318028627170417 0.9985354550922155 0.01564919834722296 1.4382126093337566e-05 1.9383804692810745e-06 0.015153569652220686 0.0050507570483375435 5.4947239602538777e-11 10.260054120446998 -0.8668947899865049 LYCIYVAIGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYCIYVAIGQK 11 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 71425000.0 28498000.0 25494000.0 17433000.0 False True 37361153.975024596 21690394.57483365 15629200.389144085 1.0 0.5805600809154174 0.41832756021379813 25.155035680510025 -13.999999999999998 0.13147242871573533 2.9938331037118657 0.1953240832385574 0.9996390019488232 0.0046565650380974875 11.934747795111118 0.11290037844876177 6.141260117678818 0.1984389569628867 1.0000000000000041e-14 13.999999999999998 -2.7985090204733085 LYCIYVAIGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYCIYVAIGQK 11 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 242598000.0 169410000.0 44793000.0 28395000.0 False True 164032172.28034583 62679078.49240916 20957497.668259393 1.0 0.3821145426598688 0.12776455604356157 27.2894035631938 -9.536773455235037 0.26635107223723187 1.4069293706875827 3.276917125549352e-16 0.9989392375961574 0.011928618312419138 0.9400899506615591 0.1087099180856578 0.4242699690990096 0.10150279593548726 2.90553789994342e-10 9.536773455235037 -1.4069293706875825 LYCIYVAIGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYCIYVAIGQK 11 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 6159583500.0 1803266500.0 1729917000.0 2626400000.0 False True 2735687116.9399385 1421199795.4467883 2107290888.807988 1.0 0.5195037790127482 0.7702967476650412 31.34925609128194 -10.557514949108784 7.752191276872551 1.0001318605720664 0.6449002633389703 0.7277474440760876 0.1023858007126558 0.00023342459698613648 1.3323532535900498e-05 0.09917088784162231 0.03304487508735228 2.7700336885448105e-11 10.557514949108784 -0.35523159723309605 LYCIYVAIGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYCIYVAIGQK 11 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 160181000.0 28498000.0 38045000.0 93638000.0 False True 39034480.72949254 36364046.10200913 71522632.9351449 1.0 0.9315878019233965 1.8322936951766828 25.218245742032916 -6.888578821185355 1.0307297083754197 0.9499424629667411 1.9076462695726395 0.9799738160415602 0.05793941769473279 0.12030476362172991 0.22863208019740983 0.04290758176710458 0.10643873740338684 1.2924721055427172e-07 6.888578821185355 0.9577038066058984 LYCIYVAIGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYCIYVAIGQK 11 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 314693000.0 169410000.0 22243000.0 123040000.0 False True 140871921.1355078 22123172.54411016 148767095.12731716 1.0 0.15704458607353977 1.0560450509098604 27.069808838628077 -12.021420795400928 24.196871692795355 0.9437293751208041 0.6458903366425301 0.0 0.4213433719142522 0.0 0.0 0.0 0.12227124920370568 9.518734305140587e-13 12.021420795400928 -0.297839038478274 LYCIYVAIGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYCIYVAIGQK 11 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 5518682800.0 1803266500.0 1836278000.0 1879138300.0 False True 2334364031.9468746 1734087515.0819068 1537154410.9871945 1.0 0.7428522249958018 0.658489588577664 31.12038241337439 -13.999999999999998 0.15580879629369015 2.2558510955950037 0.5715985651473565 0.9995480227685828 0.003087919957867884 11.984337783891304 0.12458410368018376 4.550634274054673 0.07879768135061084 1.0000000000000041e-14 13.999999999999998 -1.6842525304476472 LYCIYVAIGQKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYCIYVAIGQKR 12 1 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 15436300.0 6166400.0 2605600.0 6664300.0 False True 8084210.11550254 2216854.63654925 5974742.164479601 1.0 0.274220314028966 0.7390631959234019 22.946675388401317 -10.628926580463304 6.694967289767595 1.0016174765186285 0.5066417550254413 0.6003093657234198 0.18977131186769883 0.004593776674565968 0.00025461316401022933 0.18423290728402328 0.06124842753762766 2.350030070969712e-11 10.628926580463304 -0.49497572149318725 LYCIYVAIGQKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYCIYVAIGQKR 12 1 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 8374500.0 4146300.0 2247600.0 1980600.0 False True 4014677.976069871 3145078.4010791588 1461821.4432736249 1.0 0.783394937234294 0.36411922749148123 21.93685284076315 -6.960679232178195 0.4257531641710669 1.0174241900733356 0.11412361286617277 0.9997945661392615 0.0037832653679048017 0.07945937553019511 0.02024137890277764 0.00544656662592762 0.03484857403474032 1.0947646556610723e-07 6.960679232178195 -0.9033005772071628 down LYCIYVAIGQKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYCIYVAIGQKR 12 1 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 75139700.0 6794700.0 37966000.0 30379000.0 False True 10308056.65910823 31190670.670288064 24374577.334411286 1.0 3.025853630977852 2.364614217838416 23.29726903643923 -10.115951789089458 5.333122613322772 0.9999673041878346 2.69523392440916 0.8975783376488813 0.26994986000509635 0.00010494595025650375 1.7395923532300204e-05 0.261382824748952 0.08712594267537785 7.656816002966935e-11 10.115951789089458 1.6952666202213251 LYCIYVAIGQKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYCIYVAIGQKR 12 1 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 37715200.0 6166400.0 23846000.0 7702800.0 False True 8446284.720694171 22792404.871823084 5883557.284145683 1.0 2.6985124969774703 0.6965852417608454 23.00988544992421 -6.681865566205859 1.8950475820458619 2.072836314023717 0.7040399293331921 0.33281958904601805 0.7195729438923518 0.4343642888202023 3.017425926337498 0.3044918861737902 0.8012248043563344 2.0803405469821686e-07 6.681865566205859 -1.368796384690525 LYDAYELK(ub)HALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYDAYELKHALK 12 1 P08758;D6RBL5;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 1 6874280.0 2014900.0 3131380.0 1728000.0 True False 2641553.4123193584 2664190.310023639 1549203.1361464441 1.0 1.0085695400284957 0.586474280217639 21.332955150862833 -6.902266484782726 0.9468207474696033 1.0164745817487586 0.5400699149771784 0.9876607674670361 0.021881930984557266 0.10975638464032708 0.1681569981183777 0.017256515597344608 0.045431617143775554 1.2523724785056695e-07 6.902266484782726 -0.4764046667715802 LYDAYELK(ub)HALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYDAYELKHALK 12 1 P08758;D6RBL5;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 1 9866200.0 3765600.0 3470300.0 2630300.0 True False 3646063.089185231 4856008.887375426 1941345.5226914133 1.0 1.3318499347362023 0.5324497890477361 21.797908094405884 -6.7939654114564485 1.4805192979232351 1.1845166919542771 0.5230003501440105 0.8139113573211582 0.1414569684420734 0.2294814413251032 0.9935805071070155 0.07519075925000075 0.17554017696242846 1.6070692398357365e-07 6.7939654114564485 -0.6615163418102666 LYDAYELK(ub)HALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYDAYELKHALK 12 1 P08758;D6RBL5;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 1 8666700.0 3765600.0 3174000.0 1727100.0 True False 3131263.24436496 3156901.0320103243 2088228.6247918513 1.0 1.008187681981546 0.6668965404137899 21.57831336984016 -6.901403123570993 0.9523418138530277 1.0136485245812414 0.6300320210631316 0.9872519060422651 0.017951322057386917 0.11038025933789095 0.1716466045341323 0.01409898985770614 0.0369488045151474 1.254864624550238e-07 6.901403123570993 -0.38361650351810983 LYDFYLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYDFYLFK 8 0 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 0 4302700.0 1256800.0 1543700.0 1502200.0 False True 1647676.9708685128 1313385.9772954711 1346766.7541199012 1.0 0.7971137550118017 0.8173730518367337 20.652001997399793 -9.990968784824258 5.075603093328937 1.0000013892310973 0.8072434034242003 0.991783092240066 0.008270823301046025 1.3639565851811052e-07 2.712008269665273e-08 0.008008250782031651 0.0026693967411317928 1.0210128669811417e-10 9.990968784824258 -0.19275798580689696 LYDFYLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYDFYLFK 8 0 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 0 2587640.0 1439800.0 447310.0 700530.0 False True 1394094.3371066756 625923.2156908344 517040.17755047604 1.0 0.4489819655891329 0.3708789023729549 20.41089675970626 -13.999999999999998 0.275213906529192 5.3745587375392985 0.3462360239445236 0.999594641762569 0.005637037644339173 15.145278003405679 0.16612188737238012 37.18489033800651 0.03161435918699982 1.0000000000000041e-14 13.999999999999998 -5.028322713594775 LYDFYLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYDFYLFK 8 0 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 0 5796400.0 1256800.0 2427500.0 2112100.0 False True 1721472.923742936 2320245.0233309786 1613265.4800649234 1.0 1.3478254530348082 0.9371425235996503 20.715212058922685 -6.682265793945549 1.8937884144322614 1.219628141794728 0.938677249941354 0.3344719990153907 0.14734505188387118 0.433553031621931 3.008171577439557 0.06238567531880805 0.16406490202123303 2.0784242747336627e-07 6.682265793945549 -0.28095089185337385 LYDFYLFK(ub)CPQSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYDFYLFKCPQSVK 14 1 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 1 3822600.0 1260300.0 1367400.0 1194900.0 True False 1652265.5047625622 1163389.2500834533 1071263.2102901554 1.0 0.7041176171323854 0.6483602103913079 20.65601410331327 -13.999999999999998 0.2346867199150818 2.9092465599689263 0.6224317331534958 0.9995165392338472 0.003392936345976486 13.441797004980318 0.15335811731347254 11.990530100246641 0.02812254612919591 1.0000000000000041e-14 13.999999999999998 -2.2868148268154305 LYDFYLFK(ub)CPQSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYDFYLFKCPQSVK 14 1 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 1 25558600.0 3414900.0 6608700.0 15535000.0 True False 5180652.962630974 5429325.850991218 12464500.440767609 1.0 1.0480002984476993 2.4059709327523766 22.30470251406636 -6.914393807023258 0.8652724877724588 0.9635690387408019 2.599019168224181 0.9924768252119496 0.056531376971296274 0.10158385448219424 0.12353550566765278 0.04731298106913326 0.1349463246919685 1.217884751628531e-07 6.914393807023258 1.6354501294833792 up LYDFYLFK(ub)CPQSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYDFYLFKCPQSVK 14 1 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 1 6014600.0 1260300.0 1223700.0 3530600.0 True False 1726266.9683268808 1169632.8877652397 2696744.9949894547 1.0 0.6775504074545678 1.562183048432638 20.719224164836163 -6.808080088411334 1.4226778432996492 0.8238655679332524 1.5769757463235843 0.8547317015842502 0.13932353523178206 0.20943180705000206 0.8358235757274638 0.07701279794527827 0.17829906055831984 1.5556787218438625e-07 6.808080088411334 0.7531101783903319 LYDILGVPPGASENELK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYDILGVPPGASENELKK 18 1 O60884;I3L320 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 25244900.0 5035500.0 9664400.0 10545000.0 True False 6518554.014544427 9126567.644309634 8625918.200837035 1.0 1.4000908213610128 1.323287063601925 22.63612054184704 -10.08102062943238 4.411588120029635 0.999968516215215 1.361688942510097 0.9672876751780894 0.031355002904828455 21784777.738915898 0.356724798108339 7065.480771158474 0.01073365147388686 8.298113496898339e-11 10.08102062943238 0.3617204262948821 LYDLAK(ub)NADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYDLAKNADK 10 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BVE2 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 3691690.0 844950.0 841840.0 2004900.0 True False 818127.5247522455 1177991.102137603 1479756.5442892509 1.0 1.4398624499210382 1.808711355527816 19.641966213677332 -6.97315619694359 0.1663234232742725 0.6575206099741365 2.6008968748662684 0.9999976981581479 0.0005015154143802548 0.07529119735312442 0.0051678405712059314 0.016082423158213108 0.04327261762528381 1.0637603608175015e-07 6.97315619694359 1.943376264892132 LYDLAK(ub)NADK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYDLAKNADK 10 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BVE2 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 24698100.0 3974800.0 4092300.0 16631000.0 True False 6030062.196803896 3361997.091714161 13343875.56037376 1.0 0.5575393722300435 2.2128918616206636 22.52374145213905 -6.835582187125963 1.3027511470963957 0.764329323787488 2.2627459877597484 0.916589038812356 0.20209951876860976 0.17402228191741473 0.5756046581100248 0.12172581021948896 0.2801878174645044 1.4602183874018573e-07 6.835582187125963 1.4984166639722605 up LYDLAK(ub)NADK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYDLAKNADK 10 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BVE2 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 46961300.0 3974800.0 5619500.0 37367000.0 True False 5145456.955021592 5306769.885062497 30566589.417797804 1.0 1.0313505547614144 5.940500461862194 22.2948677742315 -6.90830134574812 0.9072309891112688 0.8397173838422239 6.5523907293383985 0.9902644532602796 0.2290716450611359 0.10555185535157642 0.1449420385809117 0.1859829333029512 0.5075471724768617 1.2350901388356642e-07 6.90830134574812 5.7126733454961744 up LYDMVLQFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYDMVLQFLR 10 0 A0A5H1ZRP4;Q8WX92;Q8WX92-2 A0A5H1ZRP4 NELFB Negative elongation factor B 0 16054500.0 4170800.0 5496900.0 6386800.0 False True 6327408.526323263 4515935.2475242745 5124446.1805661125 1.0 0.7137100803175734 0.8098807211905805 22.593183315149076 -10.73707370679281 9.85107003287441 1.0006121316212682 0.761795400754077 0.8910676919793521 0.03926149972921925 0.0005290883494548946 1.4121387816330088e-05 0.03810513543037375 0.012671594549866102 1.8320034753862914e-11 10.73707370679281 -0.23881673086719113 LYDMVLQFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYDMVLQFLR 10 0 A0A5H1ZRP4;Q8WX92;Q8WX92-2 A0A5H1ZRP4 NELFB Negative elongation factor B 0 12067300.0 4170800.0 4527300.0 3369200.0 False True 5399182.818759199 4275351.775183454 2756040.1709113456 1.0 0.7918516410166648 0.510455056519964 22.364309637241526 -6.966927130076221 0.32327488879248245 1.0370858197528336 0.25610063398655347 0.9999475347057023 0.0014529946994944144 0.07731294172350207 0.01258574286135759 0.004210283807054819 0.024681733802779094 1.0791277730261923e-07 6.966927130076221 -0.7809851857662802 LYEEGSNK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYEEGSNKR 9 1 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 4408000.0 1303900.0 1795700.0 1308400.0 True False 1709425.5269855598 1527788.5595837766 1173019.3190590327 1.0 0.8937438545672791 0.686206740534384 20.70508014085887 -6.960505749803362 0.42824979770900257 1.0083983674067956 0.5636165120650999 0.9997884891040844 0.0018951557045056684 0.07952099198211822 0.02046771704000637 0.0027018240434152963 0.01723911136587674 1.0952020554400536e-07 6.960505749803362 -0.4447818553416957 LYEEGSNK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYEEGSNKR 9 1 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 15477400.0 1302800.0 9018700.0 5155900.0 True False 1261443.3271166652 12619913.941899193 3805415.116315499 1.0 10.004344761761963 3.016715087005691 20.266643961112532 -6.582235234398341 2.2582359928166937 7.123415991042774 3.034640397166399 0.0 3.909541976493814 0.6926109787603449 6.646708855954759 1.4517185286687764 4.367432931925873 2.616765260667978e-07 6.582235234398341 -4.088775593876375 LYEEGSNK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYEEGSNKR 9 1 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 9524350.0 493650.0 1589000.0 7441700.0 True False 748903.1406491504 1305430.5350863328 5970844.733187018 1.0 1.7431233282781853 7.972786344588542 19.514419614294027 -6.929235774229598 0.7530363700335462 0.9025306074467107 9.227174924672864 0.9963859382838474 0.18796205818033265 0.09303661799569246 0.07963783745360171 0.17047041911882627 0.566064553325105 1.1769668362536364e-07 6.929235774229598 8.324644317226154 up LYEEGSNK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYEEGSNKR 9 1 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 9579800.0 1303900.0 1065100.0 7210800.0 True False 1785987.0665725747 1018040.3601853059 5507757.551087624 1.0 0.570015527681839 3.0838731445336665 20.76829020238176 -6.8628491366148 1.1713362740190145 0.7647217638123364 3.2123527447425944 0.9570058714075148 0.22763341806700585 0.14389099266726363 0.3735477069583378 0.15139463971081776 0.3545926727005982 1.3713580600118693e-07 6.8628491366148 2.447630980930258 up LYEEGSNK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYEEGSNKR 9 1 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 7850590.0 1302800.0 1507300.0 5040490.0 True False 1083335.9238258621 1499179.875724375 6094433.154407442 1.0 1.3838550377152974 5.625617151958375 20.04704923654681 -6.924617284884106 0.7897164068364262 0.9210428075929604 6.387998885171454 0.9953705171829558 0.1426075702969885 0.09553080969100881 0.09208716079406047 0.1259779440180743 0.3957718340615144 1.1895500377676878e-07 6.924617284884106 5.4669560775784936 up LYEEGSNK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYEEGSNKR 9 1 P25788-2;P25788 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 3861790.0 493650.0 1882940.0 1485200.0 True False 639039.6562962686 1778152.7337627145 1214908.8394388964 1.0 2.782538949254717 1.9011478043166168 19.285545936386477 -10.100763888763515 5.638010218384219 0.9999885766691593 2.3418433767858886 0.7555210189603563 0.35982642815175053 5.1668523437066525e-05 8.241445047705602e-06 0.34840339749521965 0.11613348031297177 7.9293230382015e-11 10.100763888763515 1.3418548001167294 LYEEK(ub)TGNAWHSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYEEKTGNAWHSK 13 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 9540300.0 3937200.0 3428800.0 2174300.0 True False 5161707.327899035 2917236.405357721 1949324.2933583423 1.0 0.5651688908416125 0.37765106960292805 22.299416911345173 -13.999999999999998 0.1146624606867573 3.0834905016963177 0.055645475463447426 0.9997194819194706 0.0043659429175134665 11.98731692711214 0.10348536606514107 5.7356451428538415 0.285772669893219 1.0000000000000041e-14 13.999999999999998 -3.02784502623287 LYEEK(ub)TGNAWHSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYEEKTGNAWHSK 13 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 10635210.0 2622710.0 4027300.0 3985200.0 True False 2539453.506648872 5635421.892092053 2941356.5665626787 1.0 2.2191474966315488 1.1582636023307897 21.276086630071116 -6.6125446963537255 2.1445906984805365 1.8131426807909765 1.162157464623871 0.05823823128992556 0.5252806205522046 0.6057003047794821 5.282795813465437 0.20201730576209181 0.5828425894262289 2.4403678993892295e-07 6.6125446963537255 -0.6509852161671055 LYEEK(ub)TGNAWHSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYEEKTGNAWHSK 13 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 30330100.0 8285100.0 5564300.0 16480700.0 True False 12569102.42194322 4571307.190925666 13223282.421252571 1.0 0.3636940043503066 1.052046675836397 23.58337829267746 -12.007151698199738 14.814154184198683 0.9232955992762684 0.7370833060841808 0.0 0.3202846041021464 0.0 0.0 0.0 0.09318626751459651 9.836674526589425e-13 12.007151698199738 -0.18621229319208754 LYEEK(ub)TGNAWHSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYEEKTGNAWHSK 13 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 8260500.0 3937200.0 1674200.0 2649100.0 True False 5392889.238829317 1600228.3081609588 2023437.1399270843 1.0 0.2967293110044172 0.37520465381676005 22.362626972868064 -10.524814996296053 6.286524959772307 1.0006837971524956 0.3359669824192393 0.9896337218532515 0.03203742454670462 0.00030732761382732093 2.323025919907037e-05 0.03104898859702604 0.010340034310396961 2.9866546233288565e-11 10.524814996296053 -0.6647168147332563 LYEEK(ub)TGNAWHSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYEEKTGNAWHSK 13 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 10578110.0 2622710.0 5152700.0 2802700.0 True False 2180899.570753245 5124941.382369134 3388731.611779354 1.0 2.3499208542643104 1.553822861549257 21.056491905505393 -10.313696964021247 5.373091944462614 0.9998045619265037 1.9518718579068248 0.6559050380942288 0.32500564456777725 0.0007610490230677472 9.720871275420134e-05 0.3147481041049896 0.10489512073617983 4.856272362050357e-11 10.313696964021247 0.9520672959803211 LYEEK(ub)TGNAWHSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYEEKTGNAWHSK 13 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 33667900.0 8285100.0 9308500.0 16074300.0 True False 10725225.27373688 8790473.79217087 13148942.336246064 1.0 0.8196073805271313 1.2259828582290202 23.35450461476991 -6.786081871945625 1.5124292426918995 0.8986610941104799 1.2298220071201844 0.7882206245885846 0.07650728666433661 0.24124876804616793 1.0902865611319046 0.03983031838033344 0.09350660044238926 1.6365079825720565e-07 6.786081871945625 0.3311609130097045 LYELHVFTFGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYELHVFTFGSR 12 0 A0A0J9YWJ4;K7EJD2;A0A0J9YWB6;A0A0A0MR03;Q9Y5B0-4;Q9Y5B0 A0A0J9YWJ4 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 0 24448400.0 5290600.0 11016000.0 8141800.0 False True 8026226.99466908 9050108.73159916 6532569.661322287 1.0 1.1275670047221602 0.813902929192152 22.936290527766086 -6.796272328427688 1.4709393096217092 1.070719256030231 0.8099537480964735 0.821095999268401 0.05447597599315322 0.22611261220479503 0.9661807762384118 0.029139924774036804 0.06793270947235432 1.59855532516234e-07 6.796272328427688 -0.2607655079337575 LYELHVFTFGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYELHVFTFGSR 12 0 A0A0J9YWJ4;K7EJD2;A0A0J9YWB6;A0A0A0MR03;Q9Y5B0-4;Q9Y5B0 A0A0J9YWJ4 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 0 20185400.0 5290600.0 10283000.0 4611800.0 False True 6848785.993317199 9710742.010516517 3772499.7210640414 1.0 1.417877857476042 0.5508275079328091 22.707416849858536 -6.775627653907901 1.552644288216274 1.237955229658022 0.5448457325193755 0.7517048054055482 0.17641971781605525 0.2574271240367571 1.2253727294599697 0.08951843405412117 0.21203388137374365 1.6763795184113761e-07 6.775627653907901 -0.6931094971386466 LYEPDQLQELK(ub)IENLDPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYEPDQLQELKIENLDPR 18 1 Q9NZB2;Q9NZB2-6;Q9NZB2-4;A0A0C4DG79 Q9NZB2 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 1 12109800.0 3833300.0 5184000.0 3092500.0 True False 5025493.421730009 4410567.407073736 2772517.765354679 1.0 0.8776386788215939 0.5516906565565156 22.26083382176209 -6.954087903524585 0.5120059947154801 1.0059012198811126 0.40907937269976036 0.9994842503195448 0.004296924169115881 0.08188465658324733 0.02948188908098582 0.004932249775182563 0.02690502022188507 1.1115067296085487e-07 6.954087903524585 -0.5968218471813522 LYEPDQLQELK(ub)IENLDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYEPDQLQELKIENLDPR 18 1 Q9NZB2;Q9NZB2-6;Q9NZB2-4;A0A0C4DG79 Q9NZB2 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 1 61100000.0 20388000.0 26177000.0 14535000.0 True False 30930086.562452875 21505509.82816551 11662150.879083188 1.0 0.6952942011572579 0.3770487630396834 24.88250753524126 -7.08217221588549 0.257216881131957 1.0981550078198794 5.893398823073482e-15 0.9999807067414682 0.0011171451647445257 0.07473022804068537 0.009688622889730854 0.007746089726887001 0.03056948942115643 8.276139151802333e-08 7.08217221588549 -1.0981550078198734 down LYEPDQLQELK(ub)IENLDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYEPDQLQELKIENLDPR 18 1 Q9NZB2;Q9NZB2-6;Q9NZB2-4;A0A0C4DG79 Q9NZB2 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 1 19755000.0 3833300.0 5708700.0 10213000.0 True False 5250574.601037398 5456470.757853587 7800899.743337471 1.0 1.0392140236947607 1.4857230562529642 22.324043883284983 -6.924162515722608 0.7932218084560011 0.9915468492909573 1.5651094049095382 0.9952618617698815 0.015164959779348173 0.0957833048639694 0.09336599563636712 0.01336316622459204 0.04177252852724527 1.1907963211812783e-07 6.924162515722608 0.5735625556185809 LYEQLSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYEQLSGK 8 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 22608500.0 1888600.0 10731000.0 9988900.0 False True 2475972.8892284147 9129976.62911039 8955344.44829469 1.0 3.6874299669555577 3.6168992347430087 21.239564087111468 -10.122326059020565 4.376177509157394 0.9996225717833205 3.652164600987662 0.9994698645538831 0.02879405156399208 10123124.952902772 17506091.569844875 52248.04885883972 0.010537543656497584 7.545255333071578e-11 10.122326059020565 2.6525420292043416 LYEQLSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYEQLSGK 8 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 21770300.0 7287200.0 2189100.0 12294000.0 False True 7055871.824811608 3063219.0460056914 9073832.58790566 1.0 0.43413756968118955 1.285997366901989 22.750392922823316 -6.727618958152776 1.7319487363426782 0.6585706532118615 1.285273391916984 0.5482124574920733 0.2379221847478663 0.34070108899087503 2.0010474441506068 0.1089131614351418 0.2709883977527822 1.8723241620856166e-07 6.727618958152776 0.6267027387051226 LYEQLSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYEQLSGK 8 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 21405200.0 1888600.0 9488600.0 10028000.0 False True 2586866.457495948 9069362.277395818 7659592.9331428725 1.0 3.5059259634820266 2.9609541346626975 21.30277414863436 -10.104405881115822 5.200354293848415 0.999950845059462 3.2334400490753366 0.9572547086154312 0.22248381747683743 0.00012679773135734402 2.1836064477009383e-05 0.2154236911821847 0.07180634332254265 7.863105793496045e-11 10.104405881115822 2.2334892040158745 LYEQLSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYEQLSGK 8 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 9182260.0 7287200.0 1027000.0 868060.0 False True 6059629.6776971305 1021467.3471564618 1049567.332544041 1.0 0.16856926932615043 0.17320651398996267 22.530798198257592 -10.186258809389416 5.100826137318284 1.000058595049239 0.1708878916573716 0.9999765388865542 0.0018931472088509623 1.2615872950740763e-06 2.0126467992143468e-07 0.001833160565413563 0.0006110106339740015 6.512401844181261e-11 10.186258809389416 -0.8291707033918675 LYEQLSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYEQLSGK 8 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 4993430.0 849930.0 2215300.0 1928200.0 False True 1100251.139625012 2092016.607594791 1577287.385002748 1.0 1.9013991735630404 1.433570326080571 20.069401435381106 -10.305870654737632 5.0785394348784365 0.9998008051550841 1.6674847498219585 0.7307655498376341 0.1909903272149284 0.0004308806205475755 5.889260093057563e-05 0.18497975685428453 0.06164186304910073 4.9445792870921796e-11 10.305870654737632 0.6676839446668744 LYFHLGIWPEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYFHLGIWPEK 11 0 H0YHF6;Q4G104;O94952-1;O94952;H0YIE9 H0YHF6 FBXO21 F-box only protein 21 0 13206700.0 4437300.0 3256300.0 5513100.0 False True 6731708.510083002 2675187.823411976 4423433.3685224345 1.0 0.39740101928135785 0.6571041158268889 22.682541277162223 -10.372189730148488 5.9190930848067795 1.0000908995539177 0.5272525675541415 0.8154359827396597 0.10602334519288638 0.00012720475200358712 1.3491749161419745e-05 0.10267624240533775 0.03421888752010382 4.2443410099194266e-11 10.372189730148488 -0.4728383319997762 LYFHLGIWPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYFHLGIWPEK 11 0 H0YHF6;Q4G104;O94952-1;O94952;H0YIE9 H0YHF6 FBXO21 F-box only protein 21 0 13622800.0 4437300.0 4819300.0 4366200.0 False True 5744172.32225956 4551101.718494828 3571596.4009952303 1.0 0.7922989532989116 0.6217773772480222 22.453667599254672 -6.973380976798203 0.15773675794640993 1.1780355549102672 0.23152549700985908 0.9999981810715781 0.00020850263762599376 0.07522006920214507 0.004858060823184685 0.00806611724608678 0.020636197091976404 1.0632099277801425e-07 6.973380976798203 -0.9465100579004082 LYFSTCPFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYFSTCPFR 9 0 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 0 19043400.0 5488100.0 8028700.0 5526600.0 False True 7194952.246835998 6830849.25562748 4954760.446890592 1.0 0.9493946618799821 0.6886439655064371 22.77855368110121 -6.939136849573058 0.667546782827217 1.0029750176058043 0.6200783808864943 0.9980486182805783 0.006026287071337152 0.08816269160562991 0.056419836694526965 0.0058284522927464204 0.022528996561306643 1.1504378199078693e-07 6.939136849573058 -0.38289663671931007 LYFSTCPFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYFSTCPFR 9 0 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 0 20637600.0 5488100.0 8616100.0 6533400.0 False True 7517198.880325911 8235412.21236749 4990345.479596693 1.0 1.0955426806547974 0.6638570508833385 22.841763742624103 -6.84864925212278 1.2415398343940123 1.0509329328619506 0.6470393392857189 0.9383258989940284 0.04597679700720481 0.15894684644899984 0.47214301408253373 0.02898703757395853 0.06702451871059763 1.4169376748623897e-07 6.84864925212278 -0.40389359357623167 LYGAQFHPEVGLTENGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYGAQFHPEVGLTENGK 17 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 30865600.0 5418600.0 11433000.0 14014000.0 False True 7103837.073797043 9727240.965484958 12563965.71178024 1.0 1.3692939272726998 1.7686168166951957 22.760167063241855 -6.970126831575552 0.2551383226908082 0.8810211604807676 2.2686624248168323 0.9999833549665748 0.001280508993771591 0.07626157046567891 0.008882759255160765 0.008605154764224802 0.03795826316994739 1.0712064238983367e-07 6.970126831575552 1.3876412643360647 LYGAQFHPEVGLTENGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYGAQFHPEVGLTENGK 17 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 15515800.0 5992200.0 0.0 9523600.0 False True 5801980.890964448 0.0 7029083.458124149 1.0 0.0 1.211497174882236 22.468114113299205 -10.756675179622935 6.240085389075988 1.0119510372927123 0.605748587441118 0.12373084172990434 0.49459165054747256 0.08229913472711416 0.003209154703552986 0.47927301194803457 0.15962876881196655 1.7511559349847673e-11 10.756675179622935 -0.40620244985159426 LYGAQFHPEVGLTENGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYGAQFHPEVGLTENGK 17 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 22996500.0 5418600.0 9162400.0 8415500.0 False True 7422002.8521590335 8757574.871994976 6427932.2226629285 1.0 1.1799476565072229 0.8660643697803304 22.823377124764747 -6.751215500373596 1.6451974679886388 1.1056565666482991 0.865376963607953 0.6542241533376927 0.07562053376796316 0.2979406874619166 1.5869874543687756 0.03630309066520685 0.08802706404264618 1.7733093323552943e-07 6.751215500373596 -0.24027960304034612 LYGAQFHPEVGLTENGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYGAQFHPEVGLTENGK 17 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 9752000.0 5992200.0 2379300.0 1380500.0 False True 4982779.799469859 2366482.238645926 1669156.1672891846 1.0 0.4749321330430269 0.3349849350089229 22.24851938873348 -13.999999999999973 0.18559488566774107 3.7731812635236595 0.23001077133030978 0.9994924458570706 0.006449240616829238 12.282267862850773 0.13660587840316366 12.300693027158614 0.0997254245044034 1.0000000000000614e-14 13.999999999999973 -3.5431704921933496 LYGEFADPFK(ub)LAECK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYGEFADPFKLAECK 15 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 26229300.0 5356800.0 12084000.0 8788500.0 True False 7022816.675325001 10281114.303063082 7879150.32524481 1.0 1.4639588043336322 1.1219359253572114 22.743618344655943 -10.777018721127833 11.241423651058359 0.9990876476948746 1.2929473648454217 0.4944784013073724 0.13963025564165252 0.003200914771978163 6.349225279730342e-05 0.13554191857582523 0.0450654712272337 1.6710185801771194e-11 10.777018721127833 0.29385971715054715 LYGEFADPFK(ub)LAECK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYGEFADPFKLAECK 15 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 24364000.0 5356800.0 7283200.0 11724000.0 True False 7337353.722076839 6961404.141678344 8955032.663359294 1.0 0.9487622384529008 1.2204717126305547 22.806828406178834 -6.857921492545401 1.196161058957463 0.9723387298600676 1.2331182281271835 0.951064559992306 0.026076432330691377 0.1489616455965936 0.40617946822509304 0.01701646888486243 0.03963400322556125 1.387006535513777e-07 6.857921492545401 0.2607794982671159 LYGEFADPFK(ub)LAECK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYGEFADPFKLAECK 15 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 14988900.0 4739900.0 0.0 10249000.0 True False 3941436.863173324 0.0 12392018.513978183 1.0 0.0 3.144035777856185 21.910290233898586 -6.821156783934148 1.3668457008939636 0.46160426184254966 3.2144050537956343 0.8870205197418579 0.4408491062252366 0.19198565580183283 0.704467991078003 0.2534303223662489 0.5839482085153092 1.509535101010234e-07 6.821156783934148 2.7528007919530846 LYGLGTGVAQK(ub)QNEDVDSAQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYGLGTGVAQKQNEDVDSAQEK 22 1 B7Z9U0;Q9UFF9-2;Q9UFF9-3;Q9UFF9 B7Z9U0 CNOT8 CCR4-NOT transcription complex subunit 8 1 10251600.0 1401500.0 2239900.0 6610200.0 True False 1837380.072145307 1905715.6510618168 5926239.913515754 1.0 1.037191858098647 3.22537508888748 20.809218656025454 -6.910587784251126 0.8917033126866232 0.9335020186104578 3.5117638769583297 0.9911419125703625 0.09791942427686133 0.1040311749927108 0.13666136706854465 0.08040156738395973 0.22286459537666461 1.2286048227156504e-07 6.910587784251126 2.578261858347872 up LYGLGTGVAQK(ub)QNEDVDSAQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYGLGTGVAQKQNEDVDSAQEK 22 1 B7Z9U0;Q9UFF9-2;Q9UFF9-3;Q9UFF9 B7Z9U0 CNOT8 CCR4-NOT transcription complex subunit 8 1 14109300.0 2998700.0 2944400.0 8166200.0 True False 2903507.9099053936 4120114.274843156 6027227.23925127 1.0 1.419012588458009 2.0758432304211145 21.469365533644005 -6.964515027864654 0.3662869464817832 0.9473144151079583 2.570271715516386 0.9999027878458548 0.004365577374180881 0.0781260006347671 0.015443045005202568 0.008709535202488065 0.055897832768635684 1.0851380000211264e-07 6.964515027864654 1.622957300408428 up LYGLGTGVAQK(ub)QNEDVDSAQEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYGLGTGVAQKQNEDVDSAQEK 22 1 B7Z9U0;Q9UFF9-2;Q9UFF9-3;Q9UFF9 B7Z9U0 CNOT8 CCR4-NOT transcription complex subunit 8 1 57016700.0 3974700.0 18892000.0 34150000.0 True False 6029910.489492918 15520574.99613027 27400237.531523276 1.0 2.5739312421261937 4.544053776464513 22.523705155641384 -6.968089442845084 0.3003345691345618 0.6596705429157956 6.520076197897244 0.9999634105874219 0.008770109055738945 0.0769276181754659 0.011237226084984862 0.03263081003454015 0.1766289048098806 1.0762435387032714e-07 6.968089442845084 5.860405654981449 LYGLGTGVAQK(ub)QNEDVDSAQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYGLGTGVAQKQNEDVDSAQEK 22 1 B7Z9U0;Q9UFF9-2;Q9UFF9-3;Q9UFF9 B7Z9U0 CNOT8 CCR4-NOT transcription complex subunit 8 1 12169600.0 1401500.0 2551300.0 8216800.0 True False 1919672.424113404 2438575.129979128 6276161.070307977 1.0 1.270307943869839 3.2693916896819553 20.872428717548345 -6.93158880741478 0.7336386441643676 0.971320569490075 3.6968995062780614 0.9968412965418839 0.05688369739243379 0.09182132221801839 0.07370132743746333 0.052322270680891694 0.17932859202003068 1.1706072043226444e-07 6.93158880741478 2.7255789367879864 up LYGLGTGVAQK(ub)QNEDVDSAQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYGLGTGVAQKQNEDVDSAQEK 22 1 B7Z9U0;Q9UFF9-2;Q9UFF9-3;Q9UFF9 B7Z9U0 CNOT8 CCR4-NOT transcription complex subunit 8 1 13377500.0 2998700.0 3797700.0 6581100.0 True False 2493551.91493446 3777241.0363155664 7957177.582431618 1.0 1.514803447120068 3.1911016308801265 21.24977080907828 -6.949595207730808 0.5632689692525605 0.9784399015097663 3.808029151373516 0.9991691412996412 0.026964544896754893 0.08364867231732225 0.03663804088200614 0.028791650904650305 0.1394469585897164 1.1230647400514293e-07 6.949595207730808 2.8295892498637496 LYGLGTGVAQK(ub)QNEDVDSAQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYGLGTGVAQKQNEDVDSAQEK 22 1 B7Z9U0;Q9UFF9-2;Q9UFF9-3;Q9UFF9 B7Z9U0 CNOT8 CCR4-NOT transcription complex subunit 8 1 59888700.0 3974700.0 16285000.0 39629000.0 True False 5145327.503050298 15378725.434334481 32416928.6278778 1.0 2.988872025195195 6.300265358941703 22.294831477733833 -6.963465418619999 0.3834782663845409 0.7812499462161062 8.625636206260893 0.9998779342215075 0.02415345996649558 0.07848563717333758 0.016720387970725382 0.04295291561992125 0.2793529898116156 1.0877637490790693e-07 6.963465418619999 7.844386260044787 LYGLLDPSVFHVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYGLLDPSVFHVK 13 0 Q9BVI4 Q9BVI4 NOC4L Nucleolar complex protein 4 homolog 0 4516380.0 917480.0 2185000.0 1413900.0 False True 1202825.1648889577 1859006.517063292 1267603.1910864913 1.0 1.5455334418738333 1.0538548976928943 20.197995525987505 -10.398474060683728 3.7527787290399903 0.9983440570208901 1.2996941695085034 0.3312707692872514 0.20072692524307154 143852373.84740064 4726.180460771532 2059524.289790067 0.068714042645119 3.995084222281867e-11 10.398474060683728 0.30135011248761323 LYGLLDPSVFHVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYGLLDPSVFHVK 13 0 Q9BVI4 Q9BVI4 NOC4L Nucleolar complex protein 4 homolog 0 4901480.0 917480.0 1414500.0 2569500.0 False True 1256697.149964726 1352002.7128740163 1962637.020513624 1.0 1.0758381308591058 1.5617422388271611 20.261205587510396 -6.934461551384363 0.7092115658720878 0.9936912313819257 1.6738644907581297 0.9973448119163534 0.0128236945877664 0.09038631108329065 0.06680959241061461 0.012010297216508673 0.042938577494961855 1.1628894984597351e-07 6.934461551384363 0.680173259376204 LYGPTNFAPIINHVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYGPTNFAPIINHVAR 16 0 Q99829;F2Z2V0;A6PVH9;E7ENH5;B0QZ18;Q5JX45;H0Y524 Q99829 CPNE1 Copine-1 0 12293400.0 3347800.0 4853700.0 4091900.0 False True 4388998.220141315 4129546.8795744125 3668509.4402764137 1.0 0.9408859772655481 0.8358420888487617 22.065460254469595 -6.962289960240435 0.40186645578979974 1.005656857793948 0.767224103409449 0.9998459083035561 0.0008426733394962396 0.07889309880087364 0.018182184752093558 0.0013513776420467918 0.008794903179157156 1.0907118706479041e-07 6.962289960240435 -0.23843275438449896 LYGPTNFAPIINHVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYGPTNFAPIINHVAR 16 0 Q99829;F2Z2V0;A6PVH9;E7ENH5;B0QZ18;Q5JX45;H0Y524 Q99829 CPNE1 Copine-1 0 16828600.0 3347800.0 6246100.0 7234700.0 False True 4585572.13089322 5970126.648909423 5526012.863323562 1.0 1.3019371364127919 1.2050868911415757 22.128670315992487 -10.13697129613188 4.464305909611739 0.9999654945997253 1.2535120137232239 0.9013373039442831 0.0395389470976689 4487248.527597248 10189067.264621533 920.6997736772859 0.013535233537555076 7.295057239551744e-11 10.13697129613188 0.25354651912349857 LYGPTNFAPIINHVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYGPTNFAPIINHVAR 16 0 Q99829;F2Z2V0;A6PVH9;E7ENH5;B0QZ18;Q5JX45;H0Y524 Q99829 CPNE1 Copine-1 0 15616000.0 6889000.0 3731900.0 4995100.0 False True 8917946.302491624 3524216.484396245 4086043.0540541615 1.0 0.3951825190303735 0.45818206518159277 23.088280082122182 -10.10873563073013 5.163342835753943 1.0000143381084254 0.42668229211004527 0.9910250907629383 0.025719457019262853 4.2452046289811164e-06 7.327326315045949e-07 0.024903379481582666 0.008300919058656476 7.785103115433548e-11 10.10873563073013 -0.5733320459983802 LYGPTNFSPIINHVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYGPTNFSPIINHVAR 16 0 O75131 O75131 CPNE3 Copine-3 0 55639000.0 15429000.0 19352000.0 20858000.0 False True 20227568.414648548 16464757.033505196 18699814.24406398 1.0 0.8139760892654615 0.9244716844226226 24.269819566066573 -10.22470464987155 4.958243722208927 1.0000187251181614 0.8692238868571122 0.6512877205915262 0.045109637827195743 9.338680146172604e-06 1.4602758947385365e-06 0.043683470429097766 0.014559073004776994 5.960673725461314e-11 10.22470464987155 -0.1307948382610492 LYGPTNFSPIINHVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYGPTNFSPIINHVAR 16 0 O75131 O75131 CPNE3 Copine-3 0 63236200.0 26604000.0 8575200.0 28057000.0 False True 25759470.58229334 11999322.07907724 20708030.00804205 1.0 0.46582176604690734 0.8038996741756187 24.618599607192454 -10.230826855406546 5.209223536178041 1.0000359470491942 0.634860720111168 0.6086609539373431 0.13801972803750223 5.762648510850915e-05 8.508782908610875e-06 0.13365015936870323 0.04454567567805889 5.87723619574444e-11 10.230826855406546 -0.3651752269380262 LYGPTNFSPIINHVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYGPTNFSPIINHVAR 16 0 O75131 O75131 CPNE3 Copine-3 0 58680000.0 15429000.0 20567000.0 22684000.0 False True 21133518.25304724 19658281.934026055 17326506.39164468 1.0 0.9301944758389451 0.8198590591581396 24.333029627589465 -6.9643726679212525 0.3686603466194822 1.0086147883275929 0.7376062058537861 0.9998996179878243 0.0007429936490169479 0.0781744946265039 0.015614497951952688 0.0014573331809533227 0.00937751144734466 1.0854937620960664e-07 6.9643726679212525 -0.27100858247380677 LYGPTNFSPIINHVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYGPTNFSPIINHVAR 16 0 O75131 O75131 CPNE3 Copine-3 0 44629900.0 26604000.0 9974500.0 8051400.0 False True 22122404.757033493 9920765.388716776 9734910.514532518 1.0 0.4484487784069955 0.4400475726508641 24.39900488262673 LYGSAGPPPTGEEDTAEKDEL ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYGSAGPPPTGEEDTAEKDEL 21 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 33453500.0 12000000.0 4056500.0 17397000.0 False True 11619066.568467917 5676281.604368048 12840203.801187146 1.0 0.4885316364201293 1.1050977051834077 23.469990836987236 -6.686480774020001 1.8791587371699006 0.6782895232006294 1.1028692207414112 0.3539499264894863 0.216471945047633 0.4242475778013904 2.9018151413889886 0.09225650067385903 0.24129236240621801 2.0583500105581727e-07 6.686480774020001 0.42457969754078184 LYGSGDQEAWQK(ub)GVLFASGQNLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYGSGDQEAWQKGVLFASGQNLAR 24 1 P28838-2;P28838;H0Y9Q1 P28838-2 LAP3 Cytosol aminopeptidase 1 30642800.0 9919800.0 10493000.0 10230000.0 True False 9604901.378824 14682909.620272135 7550456.106578399 1.0 1.5286892640713272 0.7861044906952349 23.195339369991448 -6.715517099398131 1.775464243836831 1.3231761115253573 0.7875433266185639 0.491298713458153 0.22260484851129766 0.36408867782714216 2.2404621316168845 0.09964951505359548 0.2514844769639002 1.9252312418037292e-07 6.715517099398131 -0.5356327849067934 LYGSGDQEAWQK(ub)GVLFASGQNLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYGSGDQEAWQKGVLFASGQNLAR 24 1 P28838-2;P28838;H0Y9Q1 P28838-2 LAP3 Cytosol aminopeptidase 1 46898000.0 12107000.0 14084000.0 20707000.0 True False 18367204.14025982 11570600.161205735 16614252.373799473 1.0 0.6299597953421592 0.9045607729366941 24.130628700025945 -10.272189152831256 5.54924015744946 1.0000212849835877 0.76726028413942 0.4892230250309886 0.11210537966269783 2.9523958029820075e-05 3.872201081147129e-06 0.10855548520510695 0.0361818557044873 5.343315856690564e-11 10.272189152831256 -0.23276100084416762 LYGSGDQEAWQK(ub)GVLFASGQNLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYGSGDQEAWQKGVLFASGQNLAR 24 1 P28838-2;P28838;H0Y9Q1 P28838-2 LAP3 Cytosol aminopeptidase 1 27863100.0 9919800.0 9665500.0 8277800.0 True False 8248753.2216516705 9613430.033048457 10008649.70777719 1.0 1.1654403731966094 1.213353029098515 22.975744645425724 -13.999999999999398 0.1737625221235139 0.1571436049737582 1.253967983707453 0.9995070010639021 0.0020293991427965717 12.130478603085086 0.13207025768685313 3.4478263825101054 0.037764254421579546 1.0000000000013867e-14 13.999999999999398 1.0968243787336949 LYGSGDQEAWQK(ub)GVLFASGQNLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYGSGDQEAWQKGVLFASGQNLAR 24 1 P28838-2;P28838;H0Y9Q1 P28838-2 LAP3 Cytosol aminopeptidase 1 39271000.0 12107000.0 11811000.0 15353000.0 True False 15672750.164648881 11153707.46729657 12558911.535083087 1.0 0.7116624300216712 0.8013214913238839 23.901755022118394 -10.404102481515487 8.413462088602714 1.0000023602180286 0.7564919606727776 0.9077070070663567 0.036603158501223025 1.6204864640959375e-06 1.1480787832177351e-07 0.035441199023131524 0.01181361860781894 3.943642320165327e-11 10.404102481515487 -0.243510399545251 LYHDGK(ub)NQPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYHDGKNQPSK 11 1 A2A276;Q96BD6 A2A276 SPSB1 SPRY domain-containing SOCS box protein 1 1 10476600.0 2160200.0 4917300.0 3399100.0 True False 2832043.1194065567 4183658.007485273 3047393.7384695485 1.0 1.477257877472551 1.0760407274830326 21.433411800733936 -10.072763894689775 5.935977081091309 0.9999991332831619 1.2766493024778076 0.38797737218782047 0.16379621558806037 1.8785965415781027e-06 2.938167091250859e-07 0.15859550241061218 0.052865001262021594 8.457385081120354e-11 10.072763894689775 0.2766501691946457 LYIGLAGLATDVQTVAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYIGLAGLATDVQTVAQR 18 0 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 45115900.0 33127000.0 4506100.0 7482800.0 False True 32075401.517803013 6305409.229001071 5522830.200811812 1.0 0.19658083548857028 0.17218273005082851 24.934963989202803 LYIGLAGLATDVQTVAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYIGLAGLATDVQTVAQR 18 0 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 145426000.0 28681000.0 65877000.0 50868000.0 False True 43511173.86196347 54120734.65064968 40813917.503763534 1.0 1.243835315092725 0.9380100300957905 25.374882603222567 -6.694322936578436 1.8510575001172074 1.1522450152830657 0.9390082810069622 0.39074201737865577 0.1030363580257904 0.40743617549805544 2.709917381519957 0.04447547991190627 0.11519002533645671 2.0215154431182185e-07 6.694322936578436 -0.21323673427610346 LYIGLAGLATDVQTVAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYIGLAGLATDVQTVAQR 18 0 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 42641600.0 33127000.0 4293700.0 5220900.0 False True 27546568.274930406 4270568.985867281 6312566.05128584 1.0 0.15503088962823158 0.2291597990821522 24.71536926463708 -10.373901152821208 5.294912011334069 1.0003910405585879 0.19209534435516656 0.9937254484520225 0.030263000558602492 0.00013976374087689965 1.6526425183671678e-05 0.029315531783916715 0.009767341430798271 4.22764826298656e-11 10.373901152821208 -0.8082956962034213 LYIGLAGLATDVQTVAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYIGLAGLATDVQTVAQR 18 0 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 95954000.0 28681000.0 41444000.0 25829000.0 False True 37128119.88703184 39137604.967796035 21128387.027920336 1.0 1.0541229959092562 0.5690669792116269 25.146008925315016 -6.879194883365004 1.0842389438043487 1.0332033919721948 0.535212167143828 0.9730319671053403 0.035640286108465785 0.128347561204397 0.2765933443746221 0.025338808788470245 0.06115442415535531 1.320702854898898e-07 6.879194883365004 -0.4979912248283668 LYIMTLGCLAPYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYIMTLGCLAPYR 13 0 E7EQ69;Q9GZZ1 E7EQ69 NAA50 N-alpha-acetyltransferase 50 0 87644000.0 18013000.0 34702000.0 34929000.0 False True 27327037.926695317 28509156.97203648 28025267.840075422 1.0 1.0432582209792438 1.0255508817037948 24.703825753781338 -10.368810325878343 5.9711602883381545 0.9999941429658343 1.0344045513415185 0.834256673998645 0.007228990987865758 5.637570429187122e-07 5.958362774237867e-08 0.007000632011168685 0.0023331468088239565 4.2774966109384595e-11 10.368810325878343 0.03441040837568421 LYIMTLGCLAPYR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LYIMTLGCLAPYR 13 0 E7EQ69;Q9GZZ1 E7EQ69 NAA50 N-alpha-acetyltransferase 50 0 17099110.0 633610.0 6048900.0 10416600.0 False True 867872.7396664235 5781639.596962618 7956413.616611095 1.0 6.661851827705586 9.16771924380207 19.727123983336508 -8.74594781641548 0.3974493657529345 6.818450365143068e-20 9.693641709145364 0.9971947209382377 0.18095050369858293 0.31012613950604007 0.1344592116444385 1.159927550382755 0.6281972505899073 1.7949492898555009e-09 8.74594781641548 9.693641709145364 LYIMTLGCLAPYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYIMTLGCLAPYR 13 0 E7EQ69;Q9GZZ1 E7EQ69 NAA50 N-alpha-acetyltransferase 50 0 69620000.0 18013000.0 29420000.0 22187000.0 False True 23318183.589313652 27782751.13774154 18149193.65784464 1.0 1.1914629212574657 0.7783279340060657 24.474952075873787 -6.7806627132168655 1.5330633822580038 1.1083157950781735 0.7749733703220888 0.7698168860905014 0.08099155718754365 0.2495376157287838 1.1584253453638451 0.041606313689154795 0.09812843255001719 1.657056386084737e-07 6.7806627132168655 -0.33334242475608467 LYIQVFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYIQVFLK 8 0 Q8N766-3;Q8N766-2;Q8N766;Q8N766-4;A0A286YEW0 Q8N766-3 EMC1 ER membrane protein complex subunit 1 0 90133000.0 20519000.0 34027000.0 35587000.0 False True 31128823.13983574 27954615.99583557 28553213.851663813 1.0 0.898029966319603 0.9172596639261988 24.891747699341245 -10.863297274114936 10.494018569416937 1.003395473427232 0.9076448151238108 0.9685089260599331 0.007850491174029806 0.0006422997585254487 8.36704514526165e-06 0.007828509981106433 0.002533735131380482 1.3699437201237806e-11 10.863297274114936 -0.09575065830342111 LYIQVFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYIQVFLK 8 0 Q8N766-3;Q8N766-2;Q8N766;Q8N766-4;A0A286YEW0 Q8N766-3 EMC1 ER membrane protein complex subunit 1 0 60033000.0 20519000.0 17409000.0 22105000.0 False True 26562249.98995874 16440173.846259084 18082116.816453576 1.0 0.6189300173168282 0.6807449227113332 24.662874021433694 -10.588772185323304 6.433030064189746 1.0007921889429818 0.6498374700140915 0.9771611335164713 0.025235829452492118 0.0002873328518863481 1.836756807648986e-05 0.024486387625239577 0.008144828933102708 2.5776729534494203e-11 10.588772185323304 -0.3509547189288903 LYK(ub)DDQLLDDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYKDDQLLDDGK 12 1 B8ZZU8;Q15370;Q15370-2 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 20691800.0 5535300.0 6132300.0 9024200.0 True False 7256831.903921458 5217384.743518179 8090462.350238866 1.0 0.7189617745863455 1.1148752592528608 22.790908421396015 -6.716059361476537 1.77356150979013 0.8283025348029565 1.1141227541653245 0.4938159453430483 0.11832277981693329 0.3630373086070053 2.229524629218403 0.05301828094392792 0.13371320978983936 1.9228288893672867e-07 6.716059361476537 0.285820219362368 LYK(ub)DDQLLDDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYKDDQLLDDGK 12 1 B8ZZU8;Q15370;Q15370-2 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 31437900.0 8912900.0 6581600.0 15943400.0 True False 8629964.8681748 9209667.202590583 11767345.24825241 1.0 1.067173197489318 1.3635449770656078 23.040923255656196 -6.942629647805895 0.6346316402945631 0.9967644314124476 1.450053757902512 0.998488406972002 0.006140689624983245 0.08658725878499797 0.0492991431019819 0.006104096445651187 0.025227485553723065 1.1412225701746721e-07 6.942629647805895 0.45328932649006426 LYK(ub)DDQLLDDGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYKDDQLLDDGK 12 1 B8ZZU8;Q15370;Q15370-2 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 157285700.0 19036000.0 34140700.0 104109000.0 True False 28879003.718013234 28048025.34249337 83531810.51740435 1.0 0.9712255179010367 2.892475493027535 24.783517636496377 -6.903500926640258 0.9388665995183709 0.9276118053679208 3.109119303553274 0.9882290980841809 0.09753379560241993 0.10887410106343863 0.1632412865078887 0.07737045977722763 0.2050823043015886 1.2488177800249621e-07 6.903500926640258 2.1815074981853533 up LYK(ub)DDQLLDDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYKDDQLLDDGK 12 1 B8ZZU8;Q15370;Q15370-2 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 29165800.0 5535300.0 6317500.0 17313000.0 True False 7581849.995857959 6038371.960821196 13224025.972427472 1.0 0.7964246145887903 1.7441687687901886 22.854118482918906 -6.850516152708226 1.23267714688483 0.8913196311899849 1.7824175019381625 0.9410416943597936 0.09891142321819127 0.1568915674002053 0.45850631198302344 0.06278180838584589 0.14532247096642364 1.4108597613960627e-07 6.850516152708226 0.8910978707481776 LYK(ub)DDQLLDDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYKDDQLLDDGK 12 1 B8ZZU8;Q15370;Q15370-2 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 31108900.0 8912900.0 7538800.0 14657200.0 True False 7411471.25841843 7498186.988065354 17721952.752764255 1.0 1.0117002045374495 2.391151788200556 22.821328531090472 -6.90875782103101 0.9041513911662302 0.9555934282102531 2.564766608838943 0.9904443245660196 0.06383816816099487 0.10524520526637905 0.1432649659726878 0.0519462597972618 0.14219073992700113 1.2337926507106846e-07 6.90875782103101 1.60917318062869 up LYK(ub)DDQLLDDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYKDDQLLDDGK 12 1 B8ZZU8;Q15370;Q15370-2 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 184484500.0 19036000.0 30116500.0 135332000.0 True False 24642477.25565841 28440490.300468866 110702964.62358263 1.0 1.154124644426256 4.4923634695924495 24.554643958588827 -6.916545760693658 0.8499581943403246 0.9167822700299385 4.990110322494099 0.9931662426602172 0.1331937777740949 0.10024692053221954 0.1164631789918277 0.11270843894907782 0.32722589652677775 1.2118649903890983e-07 6.916545760693658 4.07332805246416 up LYK(ub)EELEQTYHAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYKEELEQTYHAK 13 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 13567400.0 4874300.0 5112800.0 3580300.0 True False 4719568.01455693 7154367.702899781 2642512.0233023083 1.0 1.5158946074795423 0.5599054860851254 22.17022338404315 -6.760140571582908 1.612023084027016 1.2996062465491232 0.55639742415148 0.6915280871019989 0.21699000010773722 0.2826719920895345 1.4477868454430027 0.10620652793845314 0.25518724310899016 1.7372384318210056e-07 6.760140571582908 -0.7432088223976432 LYK(ub)EELEQTYHAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYKEELEQTYHAK 13 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 12673200.0 4874300.0 5625100.0 2173800.0 True False 4053196.4181028595 5594796.469805067 2628331.5294844145 1.0 1.3803418074724763 0.648458958896108 21.950628659477427 -6.765484030980936 1.5917256576689407 1.219416708691577 0.6450282094000651 0.7129447570443208 0.1601255907103049 0.2738223900535252 1.368401809415715 0.0793277885227741 0.18962726583944947 1.7159948061333115e-07 6.765484030980936 -0.5743884992915119 LYK(ub)LELEQTYQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYKLELEQTYQAK 13 1 Q03252 Q03252 LMNB2 Lamin-B2 1 8867700.0 2225800.0 4835900.0 1806000.0 True False 3048738.409983313 4622233.947817219 1379459.9957375373 1.0 1.5161136595653408 0.4524691233660442 21.539780937838415 -6.774755769238327 1.5561992142198633 1.2942260695545444 0.4453730468040953 0.748435365834184 0.21782555164273298 0.2588072733978509 1.237530416452453 0.1102876861841435 0.2614076108052663 1.6797483794058934e-07 6.774755769238327 -0.8488530227504492 down LYK(ub)LELEQTYQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYKLELEQTYQAK 13 1 Q03252 Q03252 LMNB2 Lamin-B2 1 10987400.0 5141500.0 4194700.0 1651200.0 True False 4275385.0570698995 4172102.318517236 1996458.2857137998 1.0 0.9758424709882277 0.46696572567479017 22.02762292965215 -6.916799033416536 0.8481247249796009 1.0125749271262832 0.3906557713878063 0.993244610683294 0.020200842052849794 0.10009217790769301 0.11564314385848853 0.01711624607496768 0.04980242948633472 1.2111584585832623e-07 6.916799033416536 -0.6219191557384769 down LYK(ub)LELEQTYQAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYKLELEQTYQAK 13 1 Q03252 Q03252 LMNB2 Lamin-B2 1 24696800.0 8436500.0 10080000.0 6180300.0 True False 10921215.558277054 9519039.13896786 5055548.815233109 1.0 0.8716098577281078 0.46291081686429775 23.380630104929022 -6.950110923072781 0.5576288016660863 1.0054130573893998 0.3096547190199087 0.9992099294788129 0.006436874052057307 0.08344132097699808 0.03577889345300053 0.00691989031101255 0.033956702016341905 1.1217319163712654e-07 6.950110923072781 -0.6957583383694911 down LYK(ub)PEVQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYKPEVQLR 9 1 H9KV28;A0A140T8Z0;A0A0G2JH68;O60610-2;O60610-3;O60610;A0A2R8Y5N1 H9KV28 DIAPH1 Protein diaphanous homolog 1 1 4726700.0 1087800.0 2334500.0 1304400.0 True False 1053268.384431615 3266678.024256672 962738.5088387952 1.0 3.1014678428988445 0.9140486157840262 20.006441667181942 -6.6552992222925615 1.9897583794632736 2.357909555029587 0.9232568952193346 0.21574168952408246 0.8957759505142353 0.49568847561744706 3.767526139228224 0.3643715187966503 0.9924609569521097 2.211570446168589e-07 6.6552992222925615 -1.4346526598102525 LYK(ub)PEVQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYKPEVQLR 9 1 H9KV28;A0A140T8Z0;A0A0G2JH68;O60610-2;O60610-3;O60610;A0A2R8Y5N1 H9KV28 DIAPH1 Protein diaphanous homolog 1 1 3854190.0 1087800.0 2004500.0 761890.0 True False 904553.8977109091 1993701.3606379 921197.676418658 1.0 2.204071383345116 1.0183999856170738 19.78684694261622 -6.642662062163978 2.0355886061921296 1.7858244916429304 1.0234191471509257 0.1646762987074082 0.5148502454153238 0.5266362819970319 4.174117307322255 0.20577424681514844 0.5698712357707115 2.2768684427045406e-07 6.642662062163978 -0.7624053444920047 LYK(ub)YDYNSGEELESYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYKYDYNSGEELESYK 16 1 Q9Y3F4;Q9Y3F4-2;H0YH33 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 1 4834000.0 1257100.0 0.0 3576900.0 True False 1217194.0486017512 0.0 2640002.585300128 1.0 0.0 2.1689249863921245 20.215127754334564 -6.781329102416784 1.5306439372106202 0.43475801272881126 2.186849076521133 0.7721020584302047 0.4231338140744926 0.24850124230242326 1.1500414622910244 0.21771114182975088 0.5131495095256418 1.654515718928571e-07 6.781329102416784 1.7520910637923217 LYKDDQLLDDGK(ub)TLGECGFTSQTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYKDDQLLDDGKTLGECGFTSQTAR 25 2 B8ZZU8;Q15370;Q15370-2 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 12634900.0 2327900.0 4851800.0 5455200.0 True False 3051899.443415665 4127930.3521682783 4890748.233973426 1.0 1.3525774451953525 1.6025260086878006 21.541275997133738 -6.974831881396009 0.08298817711509296 0.16974607053762533 2.7916387808804592 0.999999882509274 8.452420548152843e-05 0.07476369887744555 0.0024111857711350657 0.02871471393573087 0.047128060632110405 1.0596638494996356e-07 6.974831881396009 2.6218927103428338 LYKDDQLLDDGK(ub)TLGECGFTSQTAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYKDDQLLDDGKTLGECGFTSQTAR 25 2 B8ZZU8;Q15370;Q15370-2 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 66176500.0 7608500.0 13535000.0 45033000.0 True False 11542650.755857497 11119573.50056233 36132207.8113349 1.0 0.9633466121219626 3.1303214985517127 23.460471239423825 -6.903055919442276 0.9417707530662337 0.9173027875529074 3.3724217054295367 0.9880256364626172 0.11084922526943304 0.10918993806426808 0.1650152325008687 0.08774659061625863 0.23200249896316122 1.2500980581359816e-07 6.903055919442276 2.4551189178766295 up LYKDDQLLDDGK(ub)TLGECGFTSQTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYKDDQLLDDGKTLGECGFTSQTAR 25 2 B8ZZU8;Q15370;Q15370-2 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 10836900.0 2327900.0 2976800.0 5532200.0 True False 3188587.5391320637 2845275.1330387895 4225608.299235444 1.0 0.8923308825992827 1.3252288818721463 21.60448605865663 -6.840867136357615 1.27838051730405 0.9427282373409378 1.339711851875384 0.9259335239467459 0.05008107644752321 0.1677870457836787 0.5322778230076778 0.0307143665406925 0.070776469176583 1.442556605139903e-07 6.840867136357615 0.3969836145344463 LYKDDQLLDDGK(ub)TLGECGFTSQTAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYKDDQLLDDGKTLGECGFTSQTAR 25 2 B8ZZU8;Q15370;Q15370-2 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 82391500.0 7608500.0 8448000.0 66335000.0 True False 9849353.235956961 7977861.373611161 54262710.65457803 1.0 0.8099883497412237 5.509266380708284 23.231597561516274 -6.89747765793871 0.9770906164602102 0.7908708509927004 5.978003884558079 0.9852686440347902 0.2636047828210721 0.11328531951876906 0.18808219260288878 0.20326456431383155 0.5224664772914464 1.2662584078625837e-07 6.89747765793871 5.187133033565379 up LYKDDQLLDDGK(ub)TLGECGFTSQTARPQAPATVGLAFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFR 37 3 B8ZZU8;Q15370;Q15370-2 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 150445300.0 7054300.0 25561000.0 117830000.0 True False 10701888.838410418 20999439.840995464 94540848.8532764 1.0 1.9622180867386556 8.834033905674433 23.351362112923614 -6.932270975378064 0.7279091084716269 0.9037996143684576 10.32999377662309 0.9969660454160035 0.19214523143313078 0.09147577871926292 0.07202824788774675 0.17748028695871432 0.6142012407769671 1.1687699166476349e-07 6.932270975378064 9.426194162254632 LYKDDQLLDDGK(ub)TLGECGFTSQTARPQAPATVGLAFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYKDDQLLDDGKTLGECGFTSQTARPQAPATVGLAFR 37 3 B8ZZU8;Q15370;Q15370-2 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 189519300.0 7054300.0 24365000.0 158100000.0 True False 9131930.411041768 23009066.33144366 129327422.24299066 1.0 2.5196278657163784 14.162112107930202 23.122488435016063 -6.930910242678342 0.7392852075419456 0.828796985152137 16.608593755055338 0.9967140834872547 0.33701990335352755 0.09216799222525875 0.0753856514817282 0.30872017695355447 1.0482212986817827 1.1724376527380579e-07 6.930910242678342 15.779796769903202 LYKEELEQTYHAK(ub)LENAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYKEELEQTYHAKLENAR 18 2 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 61395400.0 20377500.0 26091100.0 14926800.0 True False 26715099.835990716 22198409.58231123 13382317.923976127 1.0 0.8309311856811938 0.5009271163549014 24.671152072823453 -6.960518618562186 0.4280674062768718 1.0133801515016363 0.30586343572736024 0.999788939053262 0.003010861188841653 0.07951645919612885 0.02045110760421004 0.004295454849176517 0.02741305060280686 1.0951696035372703e-07 6.960518618562186 -0.7075167157742761 LYKEELEQTYHAK(ub)LENAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYKEELEQTYHAKLENAR 18 2 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 57456600.0 19747600.0 20413000.0 17296000.0 True False 19120723.24728974 28564017.35238874 12765658.731122186 1.0 1.493877453429359 0.6676347210313632 24.188633758949866 -6.7448140231381 1.6691048819431251 1.2922042779397225 0.6666264275216853 0.6263460134903545 0.20749862283148163 0.30917148748818124 1.6929435651626668 0.09827803274151972 0.23989979728412272 1.799641406174246e-07 6.7448140231381 -0.6255778504180372 LYKEELEQTYHAK(ub)LENAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYKEELEQTYHAKLENAR 18 2 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 163638000.0 52762000.0 64720000.0 46156000.0 True False 80043811.4188806 53170210.34033196 37033246.36910652 1.0 0.6642638499819146 0.46266220601748087 26.25428652940872 -9.399445427003183 0.11887599406843305 1.6449072408096708 6.774135211299031e-16 0.9999107948550285 0.0020932895320771227 0.8485327782542605 0.04512159043438768 0.39376272672513324 0.21497851415471658 3.9861585882425274e-10 9.399445427003183 -1.64490724080967 LYKEELEQTYHAK(ub)LENAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYKEELEQTYHAKLENAR 18 2 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 58244500.0 20377500.0 20605000.0 17262000.0 True False 27911612.431231454 19694602.968376875 13185071.122049505 1.0 0.7056060633150585 0.4723865794043552 24.734362134346345 -7.284412135943966 0.16478627470779625 1.2440918725736543 2.5999565459898502e-11 0.9999916241379382 0.0006247515092655354 0.10528588322603208 0.009420773852647304 0.021403608012795446 0.04531027174417485 5.195027658002617e-08 7.284412135943966 -1.2440918725476546 down LYKEELEQTYHAK(ub)LENAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYKEELEQTYHAKLENAR 18 2 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 56766800.0 19747600.0 31884400.0 5134800.0 True False 16421004.367012285 31712632.40864209 6208462.939367267 1.0 1.9312236754743668 0.37808058512177745 23.969039034384142 -6.744297121966993 1.6707398865792331 1.5512756197561475 0.37623536428154936 0.6242311638294897 0.3912443467999383 0.3100624320990679 1.7009223042870092 0.18512913745717277 0.45220456147927335 1.8017846306381692e-07 6.744297121966993 -1.175040255474598 LYKEELEQTYHAK(ub)LENAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYKEELEQTYHAKLENAR 18 2 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 161061700.0 52762000.0 69979000.0 38320700.0 True False 68301449.09450759 66084607.13351514 31346725.80358614 1.0 0.9675432660597721 0.45894671663864983 26.02541285150117 -6.919900932601784 0.8254637845273213 1.0112620915036425 0.37711827072568904 0.9941532652640408 0.01894466109045687 0.09823023884577911 0.10591758885959868 0.01631417027726066 0.04882231854362564 1.2025387157794177e-07 6.919900932601784 -0.6341438207779535 down LYLINSPVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYLINSPVVR 10 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 6218300.0 1533000.0 3032400.0 1652900.0 False True 2009777.8455931174 2579977.740202623 1481873.7637363763 1.0 1.2837128968556375 0.7373321220480723 20.938604608651737 -6.765581245755499 1.5912737635046503 1.1636486030391102 0.7347533936149444 0.7133868424642232 0.11944698820774526 0.2736474009706372 1.3667548626179555 0.05919068335924927 0.1414826424267875 1.7156107317652694e-07 6.765581245755499 -0.4288952094241658 LYLINSPVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYLINSPVVR 10 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 3706200.0 1353600.0 1010700.0 1341900.0 False True 1310630.7089231801 1414277.7807308722 990416.1338629092 1.0 1.079081827628508 0.7556790231755208 20.32182980983658 -6.84205161975362 1.2727983159704643 1.0420647993305203 0.7446001270280916 0.9279332053160921 0.036953403329534715 0.16641268391859834 0.5227887065353499 0.022757594337025667 0.05246251376350029 1.438627574438073e-07 6.84205161975362 -0.2974646723024287 LYLINSPVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYLINSPVVR 10 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 6968200.0 1533000.0 2465300.0 2969900.0 False True 2099791.5277672824 2356374.894343094 2268470.7870104737 1.0 1.1221946860832597 1.0803314314838428 21.001814670174628 -10.32536054154072 4.3309996695264505 0.9998787762345168 1.1012630587845937 0.8863822329146708 0.017090602126979045 2.0028746271296426e-05 3.1198863146239767e-06 0.016567690619638472 0.005515968117381008 4.72758622397316e-11 10.32536054154072 0.10138428255007692 LYLNVLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYLNVLNR 8 0 Q10713;Q10713-2;Q5SXN9 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 32967200.0 9541600.0 7407600.0 16018000.0 False True 12509130.000985848 6302414.954598643 14360611.015505651 1.0 0.5038252024003227 1.1480103743724694 23.57647811903027 -6.701010128903492 1.827459939797026 0.6921919799829147 1.1461166571718426 0.4222393916356596 0.2094043238087601 0.3934495742039091 2.5552857111011282 0.0913951734038399 0.23473481782854913 1.9906269117267805e-07 6.701010128903492 0.4539246771889279 LYLNVLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYLNVLNR 8 0 Q10713;Q10713-2;Q5SXN9 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 36739500.0 10726000.0 9262500.0 16751000.0 False True 10385509.001115566 12961064.5532994 12363410.580771716 1.0 1.2479951201146884 1.1904482081180319 23.30806858962759 -10.031125519557493 4.437157728110099 0.9999891269537864 1.219221664042749 0.9508578667992358 0.023493428531221903 16241938.151423248 0.04488325443564578 1827.2262699718062 0.008042425461862996 9.308388060556541e-11 10.031125519557493 0.2192325370889625 LYLNVLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYLNVLNR 8 0 Q10713;Q10713-2;Q5SXN9 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 35942700.0 9541600.0 9606100.0 16795000.0 False True 13069387.372044565 9181670.738875272 12828366.903882587 1.0 0.7025326036716056 0.9815583958680787 23.63968818055316 -10.524023165840518 8.51309970463215 1.0000140117944196 0.842045499931331 0.29936734142780785 0.11391180265953521 3.029638637394365e-05 1.6938010577659366e-06 0.11030440495395118 0.03676487621973714 2.9921050295224105e-11 10.524023165840518 -0.15796851186308858 LYLNVLNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYLNVLNR 8 0 Q10713;Q10713-2;Q5SXN9 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 20379200.0 10726000.0 4648300.0 5004900.0 False True 8919144.242367366 4623258.685284684 6051401.449957 1.0 0.5183522723316284 0.6784733249645041 23.088473865061868 -10.263729257524169 5.1219440457095775 1.0000680208912267 0.5984127986479466 0.8934685840020731 0.06536914600506268 5.078377419658236e-05 7.300045872936063e-06 0.06330408285239034 0.021097801152724176 5.448422057573086e-11 10.263729257524169 -0.4016552222432801 LYLVFEFLHQDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYLVFEFLHQDLK 13 0 E7ESI2;G3V5T9;P24941-2;P24941 E7ESI2 CDK2 Cyclin-dependent kinase 2 0 26198500.0 5571500.0 10801000.0 9826000.0 False True 8452372.831209844 8873477.161401814 7883886.793111211 1.0 1.0498208418631356 0.932742432278953 23.01092497477432 -6.791125871979275 1.4922447644153651 1.0278043668584393 0.9314656130171612 0.8048209661413637 0.021194215617011878 0.23368211055144497 1.028030166112681 0.011179591018660513 0.026148186357242396 1.6176111359341336e-07 6.791125871979275 -0.0963387538412781 LYLVFEFLHQDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYLVFEFLHQDLK 13 0 E7ESI2;G3V5T9;P24941-2;P24941 E7ESI2 CDK2 Cyclin-dependent kinase 2 0 12793300.0 5571500.0 3430700.0 3791100.0 False True 7212416.580684004 3239778.529172332 3101158.69997092 1.0 0.44919459281497587 0.42997498345787666 22.78205129686677 LYLVSDVLYNSSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYLVSDVLYNSSAK 14 0 E7ET15;O15042-2;O15042;O15042-3 E7ET15 U2SURP U2 snRNP-associated SURP motif-containing protein 0 7280900.0 1773800.0 2042100.0 3465000.0 False True 2429621.7951426003 1951873.2696783498 2646638.363915046 1.0 0.803365064299561 1.0893211318758806 21.212300324826902 -6.721681184018843 1.7535522526171332 0.8805841095532327 1.0889096688629145 0.5203410193851261 0.08272789190430642 0.3520458942531835 2.1165493005506026 0.03744881881368144 0.09381500405570571 1.8980988059799832e-07 6.721681184018843 0.20832555930968177 LYLYLQLPSGPTTGDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYLYLQLPSGPTTGDK 16 0 F6S3S0;A0A0A0MT34;A0A0A0MSM9;F6X9D6;F6R6G4;F6UE82;A0A0A0MSQ2;F8W689;P48382-2;P48382 F6S3S0 RFX5 DNA-binding protein RFX5 0 24388200.0 10277000.0 8325000.0 5786200.0 False True 15590960.349339228 6839338.706478117 4642555.033818449 1.0 0.4386733436063148 0.297772230176649 23.89420646001873 -13.999999999999822 0.19410756509549923 4.052984221806252 0.2007622146215129 0.9994876700702063 0.006865711649712011 12.420521533598572 0.13971566948569286 14.363057662812944 0.09382645049504251 1.000000000000409e-14 13.999999999999822 -3.8522220071847393 LYLYLQLPSGPTTGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYLYLQLPSGPTTGDK 16 0 F6S3S0;A0A0A0MT34;A0A0A0MSM9;F6X9D6;F6R6G4;F6UE82;A0A0A0MSQ2;F8W689;P48382-2;P48382 F6S3S0 RFX5 DNA-binding protein RFX5 0 5947300.0 2194500.0 2168100.0 1584700.0 False True 1824823.982833785 2156420.014965847 1916053.4431750637 1.0 1.1817139818697056 1.049993567160164 20.79932588189791 -10.278957008239733 3.8977069445563983 0.9998314025620241 1.1158537745359227 0.5077435012206271 0.053774634538032995 38095028.4588569 18.25433353950441 61284.32322925466 0.01840848765869163 5.2606934056737055e-11 10.278957008239733 0.11602237197389864 LYMVLITTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYMVLITTK 9 0 P48444;B0YIW6;Q6P1Q5 P48444 ARCN1 Coatomer subunit delta 0 38284000.0 11319000.0 16160000.0 10805000.0 False True 14839318.61335192 13748990.991186619 9687002.248878665 1.0 0.9265244145924422 0.6527929281175098 23.822921512524225 -6.946510324326283 0.5959326094307483 1.0031128625089174 0.5622897829627482 0.9988981296863022 0.004959208971362319 0.08491819393672967 0.04200144850384808 0.005110470792456798 0.02297369333419784 1.1310705004825071e-07 6.946510324326283 -0.44082307954616917 LYMVLITTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYMVLITTK 9 0 P48444;B0YIW6;Q6P1Q5 P48444 ARCN1 Coatomer subunit delta 0 38478000.0 16836000.0 10304000.0 11338000.0 False True 16301550.395560486 14418440.934650132 8368237.667290906 1.0 0.884482799781842 0.5133399869481057 23.958505845945048 -6.949900126306647 0.5599396329422661 1.0048555787069051 0.3752315578575155 0.9991934175255465 0.005896294294341834 0.08352588877491504 0.036128623233008396 0.006320951619583135 0.030851616606857833 1.122276511951329e-07 6.949900126306647 -0.6296240208493896 LYMVLITTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYMVLITTK 9 0 P48444;B0YIW6;Q6P1Q5 P48444 ARCN1 Coatomer subunit delta 0 139905000.0 34764000.0 43344000.0 61797000.0 False True 52739529.588832274 35608924.55178232 49582795.86341274 1.0 0.6751847206335833 0.9401448259013675 25.652381367327443 -9.961260738868075 6.369258780767828 1.0000000465648897 0.8076647745179921 0.41265588842868695 0.1081695100167234 7.1521612660885e-08 1.163899665257087e-08 0.10473470346651796 0.034911559238511795 1.0932997810532178e-10 9.961260738868075 -0.1923352720468976 LYMVLITTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYMVLITTK 9 0 P48444;B0YIW6;Q6P1Q5 P48444 ARCN1 Coatomer subunit delta 0 56535000.0 11319000.0 19368000.0 25848000.0 False True 15503940.184473496 18512257.71858886 19743234.756270163 1.0 1.1940356772743523 1.27343336734762 23.886131574047116 -13.999999999784995 0.12287036289094609 0.07680198343553972 1.3953910205388702 0.9996789796430305 0.002057806881975864 11.95367351709848 0.10823827767742224 2.6850219031337668 0.10825783046879446 1.000000000495067e-14 13.999999999784995 1.3185890371033304 LYMVLITTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYMVLITTK 9 0 P48444;B0YIW6;Q6P1Q5 P48444 ARCN1 Coatomer subunit delta 0 34381100.0 16836000.0 6495100.0 11050000.0 False True 13999879.961262079 6460109.607123587 13360503.910572609 1.0 0.46144035698869046 0.954329890509159 23.738911121379324 -10.503954085383416 9.106287034396049 1.0000088800864484 0.7078851237489251 0.31895164247061536 0.20122130944726216 3.6278359980194214e-05 1.976133809932186e-06 0.19483761102599645 0.06494389836594129 3.133617000036875e-11 10.503954085383416 -0.2921237563375233 LYMVLITTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYMVLITTK 9 0 P48444;B0YIW6;Q6P1Q5 P48444 ARCN1 Coatomer subunit delta 0 127224000.0 34764000.0 55629000.0 36831000.0 False True 45002683.30088822 52533197.248178884 30128135.917973377 1.0 1.1673347763941453 0.6694742114939342 25.423507689419893 -6.816087352219235 1.3890141054934144 1.0905631600898638 0.6595166917606701 0.8750734252360661 0.07311398520293214 0.1986205651926064 0.7540639348319988 0.04137731788381019 0.09546817711711371 1.5272588407341459e-07 6.816087352219235 -0.4310464683291937 LYNK(ub)ITSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYNKITSR 8 1 Q92989;E9PL17 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 3681770.0 634070.0 758500.0 2289200.0 True False 820816.1143882817 716288.8082249133 1872589.0891755477 1.0 0.8726544175594457 2.281374666445366 19.64669952887088 -6.884822174909845 1.0524960575593991 0.9146490064998402 2.390939363594221 0.9773731871160412 0.09569693037310799 0.12344619623197459 0.24717818177409187 0.06970602410989202 0.17084048677939628 1.3037004789918157e-07 6.884822174909845 1.4762903570943808 up LYNLDVFQYELYNPMALYGSVPVLLAHNPHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYNLDVFQYELYNPMALYGSVPVLLAHNPHR 31 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 1388930000.0 548440000.0 334530000.0 505960000.0 False True 832023576.3346899 274830507.80518013 405956784.22985375 1.0 0.3303157694351522 0.4879150011808722 29.632049168449917 -10.31153567177083 8.590385496423124 1.000000719993713 0.40911538531090624 0.9493487820843176 0.06433961693860837 8.871038778055992e-07 7.121279546215869e-08 0.0622966414050623 0.02076552207538291 4.88050012496893e-11 10.31153567177083 -0.5908853346828069 LYNLFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYNLFLK 7 0 Q96I99;E9PDQ8;Q96I99-2 Q96I99 SUCLG2 Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial 0 14360700.0 7103400.0 1845100.0 5412200.0 False True 6877906.455204581 2581858.052069388 3994582.4574803147 1.0 0.37538429300905507 0.580784644789342 22.71353806356483 -10.196936218519143 4.9041335221032485 1.0000601543902359 0.4780844688981801 0.89592748493128 0.08385434247856335 5.515787629364848e-05 9.032281688690707e-06 0.0812009376635966 0.02706387266004273 6.354242448573293e-11 10.196936218519143 -0.5219756854920558 LYNLLLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYNLLLLR 8 0 Q9Y4E8-2;Q9Y4E8-3;Q9Y4E8 Q9Y4E8-2 USP15 Ubiquitin carboxyl-terminal hydrolase 15 0 9751800.0 2391800.0 5129100.0 2230900.0 False True 3135672.962224149 4363858.273075213 2000067.8683038813 1.0 1.3916815706379997 0.6378432612070688 21.580343669472203 -6.765475367861873 1.5915678007615373 1.2259501683548273 0.6342881878667909 0.7130447503950332 0.16490000558697734 0.2738025204897463 1.3679982816420655 0.08169879517916008 0.19531161507719755 1.716029036399194e-07 6.765475367861873 -0.5916619804880364 LYNLLLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYNLLLLR 8 0 Q9Y4E8-2;Q9Y4E8-3;Q9Y4E8 Q9Y4E8-2 USP15 Ubiquitin carboxyl-terminal hydrolase 15 0 9288000.0 4461700.0 1719900.0 3106400.0 False True 4320065.7757111015 2406665.0391600165 2292740.6499975673 1.0 0.5570899065220527 0.5307189216627546 22.04262184781704 -13.999999999999998 0.4014699839203092 8.536912949451319 0.5292242884537902 0.9998398364041237 0.002724421565706904 26.987976852441232 0.20899430917545983 177.28503551244359 0.006720432119639152 1.0000000000000041e-14 13.999999999999998 -8.007688660997529 LYNLLLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYNLLLLR 8 0 Q9Y4E8-2;Q9Y4E8-3;Q9Y4E8 Q9Y4E8-2 USP15 Ubiquitin carboxyl-terminal hydrolase 15 0 12457500.0 2391800.0 2945400.0 7120300.0 False True 3276113.095964637 2815262.488864702 5438631.787181608 1.0 0.8593300677966249 1.6600867027089696 21.643553730995094 -6.861540979723963 1.1778233864708088 0.9233357395954631 1.7000389304788475 0.9554924023931531 0.07364486145868687 0.14522846003244708 0.3819452990671973 0.048733543807488934 0.1139710432268198 1.3754950134029342e-07 6.861540979723963 0.7767031908833844 LYNLLLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYNLLLLR 8 0 Q9Y4E8-2;Q9Y4E8-3;Q9Y4E8 Q9Y4E8-2 USP15 Ubiquitin carboxyl-terminal hydrolase 15 0 7828500.0 4461700.0 1699400.0 1667400.0 False True 3710101.2368236464 1690244.9948955106 2016045.6308134666 1.0 0.45557921118686 0.5433936979411045 21.823027123251315 -10.7822878107261 7.135448024025457 1.0139939985494022 0.4994864545639822 0.9774342642555457 0.03585011409538185 0.00779213982997243 0.00023774842510954875 0.033890457848648144 0.011570574570920799 1.6508673914703627e-11 10.7822878107261 -0.51450754398542 LYNVVVDTEVTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYNVVVDTEVTGK 13 0 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 0 3813700.0 0.0 2001900.0 1811800.0 False True 0.0 1913449.4386019714 1383890.155192286 0.0 LYNVVVDTEVTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYNVVVDTEVTGK 13 0 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 0 3686680.0 1441700.0 1299100.0 945880.0 False True 1198837.4281391974 1292101.4904488407 1143659.134745017 1.0 1.0777954208973983 0.9539734979080302 20.193204600453708 -6.736872455647158 1.698244392275215 1.0464549614498977 0.9539506093529926 0.5907883416063593 0.03268956720027661 0.32349969524905825 1.8306885595404867 0.015235950059153666 0.03751538028062351 1.8328526186578608e-07 6.736872455647158 -0.09250435209690511 LYPNMTAVLLHNTQLDQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYPNMTAVLLHNTQLDQR 18 0 Q8TCS8 Q8TCS8 PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial 0 22966800.0 4942400.0 4798400.0 13226000.0 False True 6479534.262269683 4082497.424016701 11857500.392750494 1.0 0.6300603189629039 1.829992698980959 22.627458687733235 -6.82393374826802 1.354840541070914 0.8013577217923898 1.8584483700417396 0.8931706100683791 0.1639886960938935 0.18842497701538383 0.6785286422776499 0.09508959708742017 0.2189626255133349 1.4999136302505172e-07 6.82393374826802 1.0570906482493498 LYPNMTAVLLHNTQLDQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYPNMTAVLLHNTQLDQR 18 0 Q8TCS8 Q8TCS8 PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial 0 17345400.0 4942400.0 6444400.0 5958600.0 False True 6769738.843337911 6159665.099219016 4551301.401219099 1.0 0.909882233534124 0.6723008828764535 22.690668749256126 -6.954313899156449 0.5092881328411855 1.0043982107513014 0.5673745004677954 0.9994977757934844 0.0030976437178510618 0.08179836950281652 0.029140950349040632 0.0035722784172058713 0.01960724181427298 1.1109284806792855e-07 6.954313899156449 -0.43702371028350606 LYQHAVEYFLHAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYQHAVEYFLHAIK 14 0 I3L4J1;Q9UN37 I3L4J1;Q9UN37 VPS4A Vacuolar protein sorting-associated protein 4A 0 13389200.0 3999900.0 7905600.0 1483700.0 False True 5243907.6350866975 6726115.295787443 1330180.9566553696 1.0 1.282653273826445 0.2536621636420905 22.322210843828174 -6.833464341198228 1.3121924573878878 1.1507167205715267 0.22392954459707617 0.9126459282819096 0.12829195069774324 0.17658333096936166 0.5933797575772275 0.07673107326359106 0.17660142469120174 1.4673565628312097e-07 6.833464341198228 -0.9267871759744506 down LYQHAVEYFLHAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYQHAVEYFLHAIK 14 0 I3L4J1;Q9UN37 I3L4J1;Q9UN37 VPS4A Vacuolar protein sorting-associated protein 4A 0 105666300.0 52988600.0 30138000.0 22539700.0 False True 51306505.89749324 42172260.56759378 16635876.393494163 1.0 0.8219671137194757 0.32424496859582413 25.612638441913838 -6.95302483069815 0.5245863028582292 1.0081676649224396 0.11565802975160173 0.9994177796481062 0.006900510566714286 0.08229338633421945 0.03110797491705789 0.007761534323040029 0.041132013379351184 1.1142308258510017e-07 6.95302483069815 -0.8925096351708378 down LYQHAVEYFLHAIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYQHAVEYFLHAIK 14 0 I3L4J1;Q9UN37 I3L4J1;Q9UN37 VPS4A Vacuolar protein sorting-associated protein 4A 0 47961000.0 7183800.0 14213200.0 26564000.0 False True 10898349.80612856 11676743.411761524 21313613.756585196 1.0 1.0714230704170684 1.955673485962043 23.377606367402105 -6.922947917309395 0.80255625557488 0.9824841889300958 2.1084075885197433 0.9949614915523182 0.030852760353231833 0.09646805299321425 0.09685148149384305 0.027006604177100862 0.08332580993037247 1.1941313018674187e-07 6.922947917309395 1.1259233995896474 LYQHAVEYFLHAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYQHAVEYFLHAIK 14 0 I3L4J1;Q9UN37 I3L4J1;Q9UN37 VPS4A Vacuolar protein sorting-associated protein 4A 0 68889600.0 3999900.0 13609000.0 51280700.0 False True 5478771.123233105 13007709.381055122 39169254.819168344 1.0 2.3742020041492586 7.1492774452775425 22.385420905351065 -6.948109829069149 0.579223063848984 0.9427539436442657 8.816593452631468 0.9990444836939095 0.081460970722548 0.0842537354145259 0.03917280793160895 0.08542171830249055 0.3988053347867629 1.1269124343757463e-07 6.948109829069149 7.873839508987202 LYQHAVEYFLHAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYQHAVEYFLHAIK 14 0 I3L4J1;Q9UN37 I3L4J1;Q9UN37 VPS4A Vacuolar protein sorting-associated protein 4A 0 111163500.0 52988600.0 26303900.0 31871000.0 False True 44062368.69299903 26162195.669784673 38535078.74514572 1.0 0.5937537278594268 0.8745575848097444 25.393043717348114 -10.079180583440165 5.554289075305145 1.000002042350136 0.7341556563344986 0.5444302945624786 0.11463769455593334 2.8992771505307634e-06 4.80634464248988e-07 0.11099832219837179 0.036999156821850634 8.333346047593535e-11 10.079180583440165 -0.26584638601563726 LYQHAVEYFLHAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYQHAVEYFLHAIK 14 0 I3L4J1;Q9UN37 I3L4J1;Q9UN37 VPS4A Vacuolar protein sorting-associated protein 4A 0 50473300.0 7183800.0 24613900.0 18675600.0 False True 9299570.713868393 23244114.827642992 15276832.427838046 1.0 2.499482561380945 1.6427459823554866 23.148732689494555 -10.079333998362701 6.374021251235165 0.9999985495890733 2.0711142718682223 0.6757548733105829 0.3497612437650259 7.209067755177637e-06 1.0418879055639852e-06 0.3386553271245845 0.11288495602089126 8.33040280537036e-11 10.079333998362701 1.071115722279149 LYQHEINLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYQHEINLFK 10 0 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 0 9497000.0 3528800.0 2301400.0 3666800.0 False True 4626290.972947808 1958040.090786939 3287394.7104292717 1.0 0.4232418804257146 0.7105896991028624 22.141424577197814 -10.504098738859176 6.337400210728042 1.0003117795265912 0.5669157897643026 0.7517858564748916 0.11730925574346572 0.0005171259618301248 4.046521628706861e-05 0.11366360391747737 0.03786139948753576 3.1325734382878036e-11 10.504098738859176 -0.43339598976228866 LYQHEINLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYQHEINLFK 10 0 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 0 9720200.0 3528800.0 3018500.0 3172900.0 False True 4833492.722234301 2885132.689155333 2423526.367926708 1.0 0.5969043205306968 0.5014027137722519 22.204634638720705 -13.999999999999968 0.20229199095785472 3.2605565602914344 0.4407617025890389 0.9994871713202997 0.004893230656297588 12.577159984105924 0.1426041484240905 11.260412477875777 0.0597873931316954 1.0000000000000737e-14 13.999999999999968 -2.8197948577023952 LYQHEINLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYQHEINLFK 10 0 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 0 4079320.0 1731700.0 1376500.0 971120.0 False True 1439985.277317504 1369084.5212861435 1174176.702048441 1.0 0.9507628604624077 0.8154088243428238 20.457622630679534 -6.953396491458292 0.5202208087187384 1.0022961001104775 0.7578329123374234 0.999441575411986 0.0018442682725397714 0.08214987036111947 0.03053465301309269 0.0020885863341970966 0.011180560927098192 1.1132776967016727e-07 6.953396491458292 -0.2444631877730541 LYQPEYQEVSTEEQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYQPEYQEVSTEEQR 15 0 Q9Y4L1;A0A494C039;A0A087X054 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 10670800.0 4014000.0 1125200.0 5531600.0 False True 3886577.7671525134 1574498.227840482 4082708.015557096 1.0 0.4051117260916233 1.0504634823114003 21.890068952966608 -12.037065462157488 18.651179559579436 0.9157799305662749 0.7550088437813661 0.0 0.299856689671275 0.0 0.0 0.0 0.0872867485419151 9.181941846338367e-13 12.037065462157488 -0.1607710867849088 LYQTDPSGTYHAWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYQTDPSGTYHAWK 14 0 O14818;O14818-2;H0Y586;Q8TAA3-5;Q8TAA3;A0A087WYS6;Q8TAA3-2 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 0 13780600.0 5951900.0 1567300.0 6261400.0 False True 5762960.192405338 2193131.063361525 4621351.50202639 1.0 0.3805563443335461 0.8019058518079986 22.458378623680428 -9.927273002847755 6.347769523515699 1.0000000633948676 0.591231098070826 0.5565215423985144 0.1720152161143333 1.5437598708401676e-07 2.5999994071087322e-08 0.16655304288533337 0.05551767227540921 1.1822981149589919e-10 9.927273002847755 -0.4087689653240416 LYQTDPSGTYHAWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYQTDPSGTYHAWK 14 0 O14818;O14818-2;H0Y586;Q8TAA3-5;Q8TAA3;A0A087WYS6;Q8TAA3-2 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 0 20981700.0 1690600.0 10872000.0 8419100.0 False True 2315660.506747141 10391639.091103774 6430681.976807258 1.0 4.487548611217253 2.7770400531814476 21.142992328206738 -9.324102893529487 10.802705227268197 0.9999840470668908 3.632294332201097 0.7594766285398564 0.698312194702671 0.0 0.0 0.6761378751068011 0.22537929170226698 4.741296406329665e-10 9.324102893529487 2.6323102851342064 LYQTDPSGTYHAWK(ub)ANAIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYQTDPSGTYHAWKANAIGR 20 1 O14818;O14818-2;H0Y586;Q8TAA3-5;Q8TAA3;A0A087WYS6;Q8TAA3-2 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 1 38108300.0 9465300.0 11246000.0 17397000.0 True False 12409099.96209558 9568140.63656467 15596925.323807703 1.0 0.7710583898744624 1.2568941640771327 23.564895144118978 -6.778561389003212 1.541463222728677 0.8701256292836412 1.2605714584623031 0.7622725253151112 0.0967593688654035 0.25281508441273337 1.186430004801692 0.04944481780376741 0.11681071012117593 1.6650934445234924e-07 6.778561389003212 0.3904458291786619 LYQTDPSGTYHAWK(ub)ANAIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYQTDPSGTYHAWKANAIGR 20 1 O14818;O14818-2;H0Y586;Q8TAA3-5;Q8TAA3;A0A087WYS6;Q8TAA3-2 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 1 55460000.0 15839000.0 17931000.0 21690000.0 True False 15336199.614830248 25090941.808929693 16008738.313947735 1.0 1.6360599391694484 1.043853022000779 23.870437684463486 -10.283845985848195 5.0286838958121765 0.9999148680447216 1.339956480585178 0.30525552613927465 0.24176746153543854 0.00023082009898484128 3.287113425298156e-05 0.23414872693131722 0.07803011268173453 5.201804357745674e-11 10.283845985848195 0.3400416125404564 LYQTDPSGTYHAWK(ub)ANAIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYQTDPSGTYHAWKANAIGR 20 1 O14818;O14818-2;H0Y586;Q8TAA3-5;Q8TAA3;A0A087WYS6;Q8TAA3-2 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 1 192229000.0 34366000.0 37983000.0 119880000.0 True False 52135734.49113475 31204636.88746648 96185665.45472945 1.0 0.5985268490419479 1.844908610064466 25.635769217161357 -6.820008318277847 1.371756333092547 0.7836013709311203 1.8721385930644208 0.8844033676920162 0.17661275532674614 0.19348311365440582 0.7153827394507528 0.10117159934723655 0.2331930779652469 1.5135322586540325e-07 6.820008318277847 1.0885372221333005 LYQTDPSGTYHAWK(ub)ANAIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYQTDPSGTYHAWKANAIGR 20 1 O14818;O14818-2;H0Y586;Q8TAA3-5;Q8TAA3;A0A087WYS6;Q8TAA3-2 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 1 36888300.0 9465300.0 13178000.0 14245000.0 True False 12964877.200114576 12595752.386181537 10880624.384984076 1.0 0.9715288615360138 0.839238522435671 23.62810520564187 -6.941453468773501 0.6459007385546903 1.0014556811262347 0.8019851321394471 0.9983481321009401 0.0028468092438305014 0.08710978563073868 0.05163681668993187 0.0028026809089881834 0.011315046188165232 1.144317477836527e-07 6.941453468773501 -0.19947054898678762 LYQTDPSGTYHAWK(ub)ANAIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYQTDPSGTYHAWKANAIGR 20 1 O14818;O14818-2;H0Y586;Q8TAA3-5;Q8TAA3;A0A087WYS6;Q8TAA3-2 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 1 48398000.0 15839000.0 16949000.0 15610000.0 True False 13170830.286673179 16857692.372886904 18873978.827514812 1.0 1.2799263224843351 1.433013592667148 23.650842959897762 -11.770787080898911 0.09262302725685725 2.255388073247671e-19 1.8489704546454104 0.9998914689643095 0.0018677738067083196 5.110356175728737 0.06617162577702851 1.327020602465556 0.30161707783184005 1.695168677522725e-12 11.770787080898911 1.8489704546454104 LYQTDPSGTYHAWK(ub)ANAIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYQTDPSGTYHAWKANAIGR 20 1 O14818;O14818-2;H0Y586;Q8TAA3-5;Q8TAA3;A0A087WYS6;Q8TAA3-2 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 1 204330000.0 34366000.0 41006000.0 128958000.0 True False 44487464.45513529 38723980.052829035 105488967.22081962 1.0 0.8704470018038764 2.371206552515554 25.406895539253807 -6.885888988027377 1.0463682382165762 0.9112380642054665 2.4903625625570527 0.9781349540413667 0.10040141237671349 0.12254321788798472 0.24182592361931735 0.07347503468501701 0.1806674427009612 1.3005019627265607e-07 6.885888988027377 1.5791244983515862 up LYQTFK(ub)DR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYQTFKDR 8 1 O75665;O75665-3;O75665-2 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 8422900.0 1259000.0 1811500.0 5352400.0 True False 1219033.7341417577 2534841.396847701 3950445.8714418565 1.0 2.079385767476171 3.2406370396493647 20.217306619323008 -6.970193431043246 0.2535224075095337 0.6470801441223955 4.707107632198637 0.999983852706126 0.003676561448592263 0.07623997164299662 0.00880523554009261 0.02529420919642709 0.11066572020311098 1.0710421659795527e-07 6.970193431043246 4.0600274880762415 LYQTFK(ub)DR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYQTFKDR 8 1 O75665;O75665-3;O75665-2 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 24537200.0 2265800.0 3616400.0 18655000.0 True False 3437384.2521682284 2971025.1649378347 14967831.073223032 1.0 0.8643273335134923 4.354424753002707 21.712879703464285 -6.897855548766189 0.9747348880063976 0.8462336913383951 4.705212746966095 0.9854685917084269 0.19458821986075922 0.11300070557008533 0.18646007555847785 0.1503097005782995 0.38703371856583824 1.26515708298507e-07 6.897855548766189 3.8589790556276995 up LYQTFK(ub)DR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYQTFKDR 8 1 O75665;O75665-3;O75665-2 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 3902760.0 874280.0 943580.0 2084900.0 True False 1197524.9425286236 901889.5155982068 1592489.5598633406 1.0 0.7531279588163147 1.3298174453892648 20.191624274628094 -6.790430408109832 1.4951016690262309 0.8620989812397165 1.3359813624365775 0.8025586587867725 0.10497302223464296 0.23471739136027117 1.0365724941004084 0.05526867990898666 0.12932979651289592 1.620203596551322e-07 6.790430408109832 0.473882381196861 LYQTFK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYQTFKDR 8 1 O75665;O75665-3;O75665-2 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 14113100.0 2265800.0 4758700.0 7088600.0 True False 2933122.7655952317 4493874.1617665095 5798547.535178133 1.0 1.532112537012936 1.9769194809005577 21.484006025556734 -6.973189774811879 0.16506837923053336 0.5799001794169196 2.9409888143509106 0.9999977748589336 0.0005956879972339902 0.07528059793263815 0.0051221162718960685 0.019623205315623653 0.05241276316663073 1.0636781184082719e-07 6.973189774811879 2.3610886349339912 LYQVEYAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYQVEYAFK 9 0 G3V5Z7;P60900;G3V295;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 59092000.0 20619000.0 18073000.0 20400000.0 False True 27031708.674680028 15376578.84800223 18289203.690617725 1.0 0.5688348832497264 0.6765833381353653 24.688149371739947 -9.980741357759117 6.971367681583729 1.0000000295835003 0.6227091106925526 0.9423570472355062 0.043988122507187144 2.0221136420045872e-08 3.0042577724163914e-09 0.042591319648606525 0.014197105491771946 1.0453425832311216e-10 9.980741357759117 -0.3772909188909477 LYQVEYAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYQVEYAFK 9 0 G3V5Z7;P60900;G3V295;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 44633200.0 12640000.0 6589200.0 25404000.0 False True 12238750.118786182 9220301.922224058 18749930.296336025 1.0 0.753369570645218 1.532013491112572 23.544952894668455 -6.82153896411619 1.3653036446044826 0.8672728589801612 1.549565788560564 0.8878665462275321 0.1088034640863233 0.19148853077910152 0.700970076488661 0.06261870240747844 0.14426295385792054 1.5082072908372965e-07 6.82153896411619 0.6822929295804029 LYQVEYAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYQVEYAFK 9 0 G3V5Z7;P60900;G3V295;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 54639000.0 20619000.0 14519000.0 19501000.0 False True 28242401.507523544 13877502.572087549 14895265.435701959 1.0 0.4913711947757239 0.5274078917026225 24.751359433262838 -9.88229693696719 5.64064698726698 1.000000243314797 0.5093895445185324 0.995969825365848 0.014711919919204518 4.499887529733146e-08 8.918564447341866e-09 0.01424476221189094 0.004748251735781574 1.3113030248891446e-10 9.88229693696719 -0.4906106987962646 LYQVEYAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYQVEYAFK 9 0 G3V5Z7;P60900;G3V295;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 32162500.0 12640000.0 12679000.0 6843500.0 False True 10510720.046944188 12610695.710415548 8274444.209231101 1.0 1.1997937014868827 0.7872385690299832 23.32535817010273 -6.774996413821443 1.555087829908861 1.113862827037538 0.7844532012565909 0.7493806465075283 0.08433059689657198 0.2584283032862747 1.23394999733115 0.04272566241472713 0.10125599856561482 1.6788178808725598e-07 6.774996413821443 -0.329409625780947 LYQVEYAFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYQVEYAFK 9 0 G3V5Z7;P60900;G3V295;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 71053000.0 0.0 51152000.0 19901000.0 False True 0.0 48305346.233778164 16279222.201503834 0.0 LYQVEYAFK(ub)AINQGGLTSVAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYQVEYAFKAINQGGLTSVAVR 22 1 G3V5Z7;P60900;G3V295;G3V3I1;G3V3U4 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 6540400.0 2667700.0 1930900.0 1941800.0 True False 2218310.7491481854 1920497.8584463594 2347821.4021312115 1.0 0.8657478936095027 1.058382556651613 21.08103004702068 -6.719316687680196 1.7619219954737322 0.9182631144195567 1.0580680021534576 0.5092492413400811 0.05649845525136335 0.3566339796052807 2.163343232326025 0.0254656862748912 0.06397626525651884 1.9084611005795907e-07 6.719316687680196 0.13980488773390098 LYQYPNFAGPHAALANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYQYPNFAGPHAALANK 17 0 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;C9IZE1 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 11326100.0 2407100.0 4871700.0 4047300.0 False True 3155731.4103895556 4144861.349737867 3628524.2204429964 1.0 1.3134392033782778 1.149820358125813 21.589542989698156 -10.153351284488572 3.98724566983033 0.9999070828674292 1.2316297807051253 0.7276799878629884 0.06679711415975999 15580724.329714842 2.65136808789547 13946.522998708218 0.022866428832022067 7.025038610344615e-11 10.153351284488572 0.23172269783769606 LYQYPNFAGPHAALANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYQYPNFAGPHAALANK 17 0 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;C9IZE1 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 8856550.0 2850900.0 720350.0 5285300.0 False True 2760399.7400037637 1007989.5115756235 3900921.3743987144 1.0 0.3651607037081699 1.4131726350595133 21.396445771531315 -6.742731073370244 1.67685997122155 0.6234715279425804 1.4141409434419674 0.6170826490178987 0.2667211164467269 0.3128916212130682 1.7285444829774848 0.12578446558979808 0.3077238694106206 1.8082935225715228e-07 6.742731073370244 0.790669415499387 LYQYPNFAGPHAALANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYQYPNFAGPHAALANK 17 0 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;C9IZE1 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 11804800.0 2407100.0 4084100.0 5313600.0 False True 3297069.919431586 3903650.957687358 4058637.117027122 1.0 1.183975788526907 1.2309830292367079 21.652753051221048 -13.999999999999126 0.19159184286468747 0.00829496112556091 1.264171640531092 0.9994886082102432 0.0022539645297308558 12.37689248059482 0.1388064434953866 4.5847571973818395 0.031922461211061126 1.0000000000020124e-14 13.999999999999126 1.2558766794055312 LYRPGSVAYVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYRPGSVAYVSR 12 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 59052000.0 14691000.0 19969000.0 24392000.0 False True 19260043.267846372 16989703.03855235 21868149.824585684 1.0 0.8821217482369713 1.1354154048601441 24.19910760842288 -6.780176437201221 1.5353638793467252 0.9332692461841612 1.1374264984218534 0.7679504843621086 0.049852359818214655 0.25030258309018805 1.1655014661450318 0.025574259387700627 0.0603310613652351 1.6589128178277187e-07 6.780176437201221 0.2041572522376922 LYRPGSVAYVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYRPGSVAYVSR 12 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 32864200.0 12871000.0 3342200.0 16651000.0 False True 12462417.150229208 4676757.889342752 12289603.580707414 1.0 0.3752689251985709 0.9861332221960958 23.571080577874064 -10.851570235142747 11.06189903853485 1.007282531720569 0.6807010737261014 0.26701662014329286 0.24938430495464903 0.04428891535542898 0.0005942723337355304 0.23876266758808856 0.08048843832457221 1.4074395954571429e-11 10.851570235142747 -0.3265814579944675 LYRPGSVAYVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYRPGSVAYVSR 12 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 47872100.0 9061400.0 32925000.0 5885700.0 False True 13746806.277075266 27049276.505800817 4722388.815206049 1.0 1.9676771433746973 0.3435262503903395 23.712593148055376 -6.74530094212557 1.6671373877358706 1.572192172912551 0.3413976368098027 0.628571351676698 0.40656481653793936 0.30830146086072824 1.6843379395798648 0.19276911220360313 0.47034153381584887 1.7976248285728866e-07 6.74530094212557 -1.2307945361027484 LYRPGSVAYVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYRPGSVAYVSR 12 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 41921000.0 14691000.0 11204000.0 16026000.0 False True 20122659.70934713 10708970.2333266 12240988.865830434 1.0 0.5321846310581002 0.6083186339499843 24.262317669945773 -10.722739071088558 6.869375098489018 1.0053530944706452 0.5702516325040935 0.9770022318405398 0.03108157652678249 0.002561530213917322 0.00010338803223435991 0.030252489431273868 0.01003153568850833 1.8934809011598478e-11 10.722739071088558 -0.43510146196655175 LYRPGSVAYVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYRPGSVAYVSR 12 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 27667800.0 12871000.0 9917900.0 4878900.0 False True 10702806.78197934 9864470.304150987 5899055.432515182 1.0 0.9216713433302481 0.5511690113333272 23.35148585330834 -6.941051489642051 0.6497184708966587 1.0040951630865778 0.4480917329203983 0.9982982653805624 0.008075024164762962 0.08729050552817019 0.05245185937685814 0.007924447559040806 0.03174363633564414 1.1453771383039324e-07 6.941051489642051 -0.5560034301661795 LYRPGSVAYVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYRPGSVAYVSR 12 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 30564800.0 9061400.0 8421400.0 13082000.0 False True 11730160.926897606 7952741.686994447 10701210.232655307 1.0 0.6779737922229674 0.9122816216542363 23.483719470147825 -10.451945274592822 5.188130576852405 1.0002938351518251 0.7951277069385972 0.5047959016751047 0.09565577080762985 0.00032557017836375206 3.439213151387408e-05 0.09274999285853888 0.030872767275546373 3.5322767717438427e-11 10.451945274592822 -0.20516612821322788 LYSEMEQLK(ub)QK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYSEMEQLKQK 11 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 15515700.0 1119300.0 3357400.0 11039000.0 True False 1698059.9317909307 2758245.738514072 8857136.811434431 1.0 1.6243512298208294 5.216033100841663 20.695455947986456 -6.936732084498635 0.6892922290345959 0.9565118719140497 6.098075949484974 0.9977038161074839 0.0890260807731396 0.08928954194243344 0.06163828690516978 0.0846481372812813 0.31383697002758554 1.1568256658313849e-07 6.936732084498635 5.141564077570925 LYSEMEQLK(ub)QK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYSEMEQLKQK 11 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 13703800.0 1119300.0 4110400.0 8474100.0 True False 1448955.9147015344 3881652.6266680104 6931900.751608655 1.0 2.6789307992628464 4.784066016968179 20.466582270078906 -6.96806442583317 0.30084723862751434 0.6385557212427792 6.890483503351923 0.9999631049113752 0.009403370989721726 0.07693587796983055 0.011266154848579247 0.034778901947742295 0.1886313504155233 1.0763055362050617e-07 6.96806442583317 6.251927782109144 LYSILGTTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYSILGTTLK 10 0 O75083;O75083-3 O75083 WDR1 WD repeat-containing protein 1 0 26444500.0 8875000.0 7489500.0 10080000.0 False True 11635210.94562225 6372095.793842338 9037018.294187585 1.0 0.547656232759565 0.7766956986360238 23.471994031159728 -10.481585901156722 7.344431239479603 1.000052629765394 0.6621759656977995 0.7436341613629712 0.09350497039282062 8.059276057447957e-05 5.688675693669899e-06 0.09054983046540253 0.030178599426584303 3.29924144201946e-11 10.481585901156722 -0.33787666406759453 LYSILGTTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYSILGTTLK 10 0 O75083;O75083-3 O75083 WDR1 WD repeat-containing protein 1 0 21271500.0 8587400.0 2629100.0 10055000.0 False True 8314797.687505111 3678913.340575382 7421293.856465871 1.0 0.44245374076915817 0.8925405205731062 22.987249730156748 -10.007485686613759 7.070542364394972 1.0000000319286757 0.6674971306711375 0.42118718857586857 0.1837471584153478 9.245425960391136e-08 1.3123261728451425e-08 0.17791243967155826 0.05930414037129805 9.829112670491322e-11 10.007485686613759 -0.33250290125753823 LYSILGTTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYSILGTTLK 10 0 O75083;O75083-3 O75083 WDR1 WD repeat-containing protein 1 0 27156500.0 8875000.0 7107500.0 11174000.0 False True 12156327.337856898 6793467.148640558 8534931.335753731 1.0 0.5588420712795822 0.7020978539442981 23.53520409268262 -10.33426752376683 4.96656023970454 1.0001824942978577 0.630469962611829 0.8987018036890103 0.05848392837231802 0.00011823766562667089 1.5848985463496563e-05 0.0566545353863354 0.018875606717176228 4.6316152608717014e-11 10.33426752376683 -0.3697125316860287 LYSILGTTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYSILGTTLK 10 0 O75083;O75083-3 O75083 WDR1 WD repeat-containing protein 1 0 16965700.0 8587400.0 4807500.0 3570800.0 False True 7140803.586323468 4781601.043285963 4317437.770486218 1.0 0.6696166594532857 0.6046151134523929 22.767655005591024 -13.999999999999998 0.22858103709119842 3.072009720526247 0.5725810700634137 0.9995078883891421 0.0038402245673930754 13.247545650031926 0.1513928266035924 12.448016728540514 0.03404215409325021 1.0000000000000041e-14 13.999999999999998 -2.4994286504628334 LYSILGTTLKDEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYSILGTTLKDEGK 14 1 O75083;O75083-3 O75083 WDR1 WD repeat-containing protein 1 0 10022800.0 3461300.0 3270200.0 3291300.0 False True 4537797.819276879 2782298.907139758 2950747.8483789326 1.0 0.6131385790967504 0.6502598762430428 22.113560900761815 -9.774208371999157 6.29212871724938 1.0000000071346835 0.6316992281261873 0.9924385345306225 0.015154706100806731 1.521179973448534e-09 3.1275062627538494e-10 0.014673481304469509 0.004891160361939253 1.681866917363047e-10 9.774208371999157 -0.3683007790084962 LYSILGTTLKDEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYSILGTTLKDEGK 14 1 O75083;O75083-3 O75083 WDR1 WD repeat-containing protein 1 0 9412100.0 3461300.0 2930300.0 3020500.0 False True 4741036.14811539 2800829.656793725 2307120.1091501815 1.0 0.5907631938024948 0.48662782503088176 22.176770962284706 -13.999999999999988 0.1921733129412802 3.2104782104789846 0.41353197939619507 0.9994883591157561 0.00501196813357273 12.386929744905165 0.13901916220032084 10.260706827954829 0.0703969183560761 1.0000000000000286e-14 13.999999999999988 -2.7969462310827895 LYSISSQVSSAVMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYSISSQVSSAVMK 14 0 H0YLH9;Q14005-4;Q14005-3;Q14005-2;Q14005 H0YLH9 IL16 Pro-interleukin-16;Interleukin-16 0 5373900.0 1417000.0 1462100.0 2494800.0 False True 1857700.7222475186 1243960.3792211625 2236662.0278114276 1.0 0.669623672060681 1.2039948098342919 20.825086669910977 -6.739486921871331 1.6888700988435132 0.8033099383171929 1.2042558959582947 0.6025432158552406 0.13881095144460823 0.31872886627397845 1.7848907025530194 0.06503123051709829 0.15965255336174922 1.821851934611565e-07 6.739486921871331 0.40094595764110186 LYSLFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYSLFLK 7 0 Q5T9Q5;A0A2R8YDQ9;A0A2R8Y6Y7;Q9P2R7-2;Q9P2R7;A0A0U1RRI1;Q5T9Q8 Q5T9Q5 SUCLA2 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial 0 12784480.0 4124280.0 3629900.0 5030300.0 False True 5406971.019584328 3088333.069239379 4509812.810044827 1.0 0.5711761831260566 0.8340737898742294 22.3663891931726 -10.32519208317133 6.023550380657981 1.0000256191661625 0.7026249865001428 0.6304483784095831 0.10732749852198369 3.692898098556883e-05 4.1370905247957355e-06 0.10392834288234733 0.03463980119714516 4.729420361816435e-11 10.32519208317133 -0.2974006326660197 LYSLFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYSLFLK 7 0 Q5T9Q5;A0A2R8YDQ9;A0A2R8Y6Y7;Q9P2R7-2;Q9P2R7;A0A0U1RRI1;Q5T9Q8 Q5T9Q5 SUCLA2 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial 0 8113470.0 3730700.0 1814110.0 2568660.0 False True 3612270.970581935 2538493.5834586765 1895850.8878517763 1.0 0.702741738959225 0.5248362881111203 21.78447468840316 -10.037937252203786 0.09569058325481863 1.8086920158997348 1.3953680524068335e-13 0.9999399526957349 0.001518905311116127 1.6632516314258081 0.04530303135184677 0.6010048410193326 0.2782114477715245 9.163528771828422e-11 10.037937252203786 -1.8086920158995954 LYSLFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYSLFLK 7 0 Q5T9Q5;A0A2R8YDQ9;A0A2R8Y6Y7;Q9P2R7-2;Q9P2R7;A0A0U1RRI1;Q5T9Q8 Q5T9Q5 SUCLA2 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial 0 14087280.0 4124280.0 3822200.0 6140800.0 False True 5649137.770476216 3653322.5656748377 4690469.513745885 1.0 0.6467044554600881 0.8302983046827841 22.429599254695493 -10.488702073949288 7.502569884375121 1.000038143377149 0.7385013800714387 0.7300917500785917 0.07495187508484585 4.78276234123442e-05 3.259330694474849e-06 0.07258239534578051 0.024190613664218878 3.245621906877669e-11 10.488702073949288 -0.2615367633057103 LYSLFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYSLFLK 7 0 Q5T9Q5;A0A2R8YDQ9;A0A2R8Y6Y7;Q9P2R7-2;Q9P2R7;A0A0U1RRI1;Q5T9Q8 Q5T9Q5 SUCLA2 Succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial 0 6191330.0 3730700.0 1619300.0 841330.0 False True 3102242.3480328103 1610576.5094941175 1017248.2131295977 1.0 0.5191652775017446 0.3279073969751763 21.564879963837438 -13.999999999999998 0.12722053597282884 3.2849256913287412 0.050363209131775694 0.9996583746334027 0.005225958290497175 11.941905535014437 0.11063481689677698 6.8411974290878 0.24660274859917553 1.0000000000000041e-14 13.999999999999998 -3.2345624821969654 LYSLLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYSLLFR 7 0 Q9UDW1;Q9UDW1-2 Q9UDW1 UQCR10 Cytochrome b-c1 complex subunit 9 0 27010700.0 8478500.0 9989100.0 8543100.0 False True 11115395.605910799 8498765.217206832 7659141.963201783 1.0 0.7645940386222034 0.6890570731579635 23.40605596017239 -13.999999999999998 0.15902142165717234 2.156975763899435 0.6139928643367126 0.999538974511082 0.00284317681115569 12.003286390727007 0.12598480272993245 4.283788082683371 0.06833113846196362 1.0000000000000041e-14 13.999999999999998 -1.5429828995627224 LYSLLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYSLLFR 7 0 Q9UDW1;Q9UDW1-2 Q9UDW1 UQCR10 Cytochrome b-c1 complex subunit 9 0 18544000.0 10935000.0 2327500.0 5281500.0 False True 10587874.410516368 3256882.8877521553 3898116.7083962695 1.0 0.30760497919367724 0.3681680153406881 23.335909651539446 -10.334623192335568 5.339004340501796 1.0001855593234947 0.3378864972671562 0.9937641593965726 0.024724755972411104 5.4625603985050206e-05 6.807738514636792e-06 0.02394622485896839 0.007979880676669151 4.627823719230554e-11 10.334623192335568 -0.6622990620563385 LYSLLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYSLLFR 7 0 Q9UDW1;Q9UDW1-2 Q9UDW1 UQCR10 Cytochrome b-c1 complex subunit 9 0 12751000.0 4212200.0 3562900.0 4975900.0 False True 6390215.353068673 2927072.6579352436 3992411.1839855565 1.0 0.45805540129874045 0.6247694269127164 22.60743312077328 -10.352003108080508 4.978055769537177 1.0002726827263966 0.5414124141056235 0.9098188279692551 0.06806071595362095 0.00020609598579627455 2.6827622956776935e-05 0.0659380357969865 0.021966501618224867 4.446280854235424e-11 10.352003108080508 -0.4588602686207731 LYSLLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYSLLFR 7 0 Q9UDW1;Q9UDW1-2 Q9UDW1 UQCR10 Cytochrome b-c1 complex subunit 9 0 29110800.0 8478500.0 9399300.0 11233000.0 False True 11613230.572847301 8984007.846671421 8579996.750896875 1.0 0.7736010914720645 0.7388122277497547 23.469266021695283 -13.999999999999998 0.2636834903524721 2.6896680074644173 0.726538691911786 0.9995699359199033 0.0024014421699247615 14.583189288177492 0.16251204940158193 13.158935617286586 0.01491979912433947 1.0000000000000041e-14 13.999999999999998 -1.9631293155526313 LYSLLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYSLLFR 7 0 Q9UDW1;Q9UDW1-2 Q9UDW1 UQCR10 Cytochrome b-c1 complex subunit 9 0 20671100.0 10935000.0 4839300.0 4896800.0 False True 9092937.002637237 4813229.730374158 5920698.23975493 1.0 0.5293371909404156 0.6511315582674488 23.116314926973722 -10.164927750992451 7.8473091035394456 1.0000001146741324 0.5902343746039477 0.9378584709060698 0.049722342249389075 9.979360003759752e-08 1.060461251016677e-08 0.04814346449684371 0.016047816955525776 6.840254319370645e-11 10.164927750992451 -0.40976574007018474 LYSLLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYSLLFR 7 0 Q9UDW1;Q9UDW1-2 Q9UDW1 UQCR10 Cytochrome b-c1 complex subunit 9 0 20161500.0 4212200.0 7979700.0 7969600.0 False True 5452775.934875199 7535622.680279957 6519214.575001504 1.0 1.3819791552561622 1.195577198268044 22.37855944286573 -10.155497588515892 4.315458271001259 0.9999360901586692 1.2887781767803426 0.7619116789194351 0.07609828034379075 53262044.738847576 4.413279087064465 34658.38888310385 0.02605046544772012 6.990406182772429e-11 10.155497588515892 0.2888420866216733 LYSLVNLDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYSLVNLDLR 10 0 Q9Y2I1;C9J715;Q9Y2I1-4;Q9Y2I1-3 Q9Y2I1 NISCH Nischarin 0 5535800.0 2090400.0 3445400.0 0.0 False True 3171289.628710592 2830541.45096693 0.0 1.0 0.892552173519955 0.0 21.596638211768543 -7.125241821045132 0.9628299805674524 0.99695987699538 2.4628068668668757e-19 0.9896724144351321 0.04555129254364706 0.08597233977915972 0.15110409086406248 0.03787285107012932 0.06667144043434851 7.494767743153795e-08 7.125241821045132 -0.99695987699538 down LYSMK(ub)FQGPDNGQGPK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LYSMKFQGPDNGQGPK 16 1 O43396;K7ER96 O43396 TXNL1 Thioredoxin-like protein 1 1 215816800.0 84922800.0 65678000.0 65216000.0 True False 111334613.19356498 55879098.410838775 58468073.91604537 1.0 0.5019022998147761 0.5251563034973993 26.7303269458441 -10.241798747211742 5.499372390673737 1.0000329174095068 0.5135293016560702 0.9982891974201464 0.00949340724996453 3.831708849390407e-06 5.282660119950288e-07 0.009192572425082726 0.0030639840148096002 5.730615271341803e-11 10.241798747211742 -0.4865036157534366 LYSMK(ub)FQGPDNGQGPK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LYSMKFQGPDNGQGPK 16 1 O43396;K7ER96 O43396 TXNL1 Thioredoxin-like protein 1 1 299221600.0 85525100.0 79935100.0 133761400.0 True False 82810152.51457277 111853602.28603953 98725276.58401519 1.0 1.3507232976820778 1.1921880782267815 26.303304317015012 -10.416985153601718 5.712240434304707 0.9998731244416167 1.27145568795443 0.7962997842435382 0.06472173232093978 0.00010462558520743562 1.0678521051775614e-05 0.06269566158054207 0.02088884928472425 3.8283783044087313e-11 10.416985153601718 0.2715825635128134 LYSMK(ub)FQGPDNGQGPK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LYSMKFQGPDNGQGPK 16 1 O43396;K7ER96 O43396 TXNL1 Thioredoxin-like protein 1 1 606705200.0 173147400.0 213719800.0 219838000.0 True False 262677264.57051486 175579831.88958088 176386922.94158185 1.0 0.6684241674918426 0.6714967251923372 27.96871609580643 -10.343498512290124 5.7140293716607875 1.0000585186551505 0.6699604471312642 0.999935000450514 0.0012543664285841385 9.352822072978699e-07 1.0745664075263184e-07 0.0012147496908184701 0.00040484502399494826 4.5342085100511056e-11 10.343498512290124 -0.33009807152388626 LYSMK(ub)FQGPDNGQGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LYSMKFQGPDNGQGPK 16 1 O43396;K7ER96 O43396 TXNL1 Thioredoxin-like protein 1 1 248166600.0 84922800.0 68431600.0 94812200.0 True False 116321054.11237788 65408065.63896039 72419511.07855289 1.0 0.5623063351521006 0.6225830021157505 26.793537007366993 -10.369927921353856 5.82723133803977 1.0000868182078704 0.5924446686340563 0.9838594016866965 0.024607846242772246 2.7761345954236176e-05 3.0017358449150865e-06 0.023831487620205493 0.007942148223690427 4.2665032289220445e-11 10.369927921353856 -0.40764214957381406 LYSMK(ub)FQGPDNGQGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LYSMKFQGPDNGQGPK 16 1 O43396;K7ER96 O43396 TXNL1 Thioredoxin-like protein 1 1 261231600.0 85525100.0 99872600.0 75833900.0 True False 71117910.05434383 99334566.48064095 91690417.87366275 1.0 1.3967587968310053 1.2892732337550232 26.08370959244929 -10.28949682972989 5.2115303328259905 0.9999320063924013 1.3430160152929709 0.931408111027954 0.043880797375479445 3.467627681394404e-05 4.727553851489234e-06 0.042495793954473574 0.014162466454437538 5.1345592562342503e-11 10.28949682972989 0.34308400890056956 LYSMK(ub)FQGPDNGQGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LYSMKFQGPDNGQGPK 16 1 O43396;K7ER96 O43396 TXNL1 Thioredoxin-like protein 1 1 547812500.0 173147400.0 209748400.0 164916700.0 True False 224142722.545513 198075717.1563382 134903552.78823906 1.0 0.8837035390079114 0.6018645229976021 27.739842417898878 -6.956124830077059 0.48698906759555205 1.0063395023118873 0.4673382123585083 0.9995983727436433 0.003349906939632458 0.08111563468055125 0.026475912281967887 0.0040318779731901835 0.023245608695163334 1.1063057507376038e-07 6.956124830077059 -0.5390012899533789 LYSPSQIGAFVLMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 LYSPSQIGAFVLMK 14 0 P38646;A0A3B3ITI4 P38646 HSPA9 Stress-70 protein, mitochondrial 0 126537000.0 28485600.0 48821500.0 49229900.0 False True 37344897.45494282 41537522.504716426 44136062.19454617 1.0 1.1122676814103472 1.1818498697927071 25.154407800952068 LYSPSQIGAFVLMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 LYSPSQIGAFVLMK 14 0 P38646;A0A3B3ITI4 P38646 HSPA9 Stress-70 protein, mitochondrial 0 138932400.0 61695100.0 31557000.0 45680300.0 False True 59736622.820690334 44157874.667580955 33715259.05037475 1.0 0.7392094260187482 0.5643984788289229 25.832112342142054 -8.202680697933024 0.10257772144607076 1.5163538110366355 1.1205247246258811e-11 0.9999847145761893 0.0006997445828267006 0.08502194775981013 0.020118584074732535 0.13849760582517384 0.14365203517204087 6.27074733229619e-09 8.202680697933024 -1.5163538110254302 LYSPSQIGAFVLMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 LYSPSQIGAFVLMK 14 0 P38646;A0A3B3ITI4 P38646 HSPA9 Stress-70 protein, mitochondrial 0 192648200.0 32047200.0 81815000.0 78786000.0 False True 48617945.3641475 67214474.02648737 63213912.566869475 1.0 1.382503384769805 1.3002176890322792 25.5349855893431 -10.149340714132611 4.545408563971554 0.9999535891727196 1.341360536907998 0.9582402628033146 0.033592994638164494 23497861.556264486 1.1633975368694074 11413.963332833322 0.011499775582384887 7.090213059907463e-11 10.149340714132611 0.34140694773527835 LYSPSQIGAFVLMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 LYSPSQIGAFVLMK 14 0 P38646;A0A3B3ITI4 P38646 HSPA9 Stress-70 protein, mitochondrial 0 117959300.0 28485600.0 37899700.0 51574000.0 False True 39017496.114395134 36225165.936451964 39393283.39987139 1.0 0.928433896174261 1.0096312506669953 25.21761786247496 -11.169137084803703 10.364092381287158 2.753305069833545 0.9690325734206269 0.1624362860972206 0.03314868116184707 0.04646982093086059 0.0007583669154207337 0.001110625039008663 0.010698690840714438 6.774276442128199e-12 11.169137084803703 -1.784272496412918 LYSPSQIGAFVLMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 LYSPSQIGAFVLMK 14 0 P38646;A0A3B3ITI4 P38646 HSPA9 Stress-70 protein, mitochondrial 0 107983100.0 61695100.0 24726300.0 21561700.0 False True 51302209.206347056 24593094.514113735 26070151.779963218 1.0 0.4793769097778172 0.5081682091916199 25.61251761757633 -10.717378352235414 6.796003046942134 1.006076424241229 0.49377255948477955 0.997579861570602 0.011753998765918155 0.0010853224427216854 4.513466873123183e-05 0.011414079794880792 0.003793586789311957 1.9169979469643416e-11 10.717378352235414 -0.5123038647564495 LYSPSQIGAFVLMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LYSPSQIGAFVLMK 14 0 P38646;A0A3B3ITI4 P38646 HSPA9 Stress-70 protein, mitochondrial 0 183128200.0 32047200.0 76958000.0 74123000.0 False True 41485732.14475386 72675219.64848116 60633374.56620614 1.0 1.7518123916651527 1.46154765582156 25.30611191143555 -10.133215756658382 4.696631535182287 0.9999546137639029 1.6066800235600567 0.8534722636861357 0.11850008226674726 6.393415337565751e-05 1.1799139982454976e-05 0.1147469172605647 0.03824573708394563 7.358414420690117e-11 10.133215756658382 0.6067254097961537 LYSTIRPYLESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYSTIRPYLESK 12 1 Q5JTH9-2;Q5JTH9-3;Q5JTH9 Q5JTH9-2 RRP12 RRP12-like protein 0 7399700.0 1576900.0 1499600.0 4323200.0 False True 2067331.1707213228 1275865.5253950167 3875876.7350626774 1.0 0.6171558497566929 1.8748214074043714 20.9793380853672 -6.82503908775024 1.3500281677909594 0.7946347699347247 1.90533771868668 0.895561195262376 0.17010751626642076 0.18701608088202915 0.6683470662529982 0.09898163554914288 0.22787790870696228 1.4961009966496188e-07 6.82503908775024 1.1107029487519553 LYSTIRPYLESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYSTIRPYLESK 12 1 Q5JTH9-2;Q5JTH9-3;Q5JTH9 Q5JTH9-2 RRP12 RRP12-like protein 0 5997100.0 1576900.0 2222000.0 2198200.0 False True 2159922.5441201753 2123824.6928286077 1679030.4333500862 1.0 0.9832874325100988 0.7773567797237951 21.04254814689009 -6.923017149728799 0.8020465325349982 1.0040691139381532 0.741731003017213 0.9949783466265189 0.007174655294314675 0.09642955625349614 0.09665764725432738 0.006282536629146004 0.019397617676405972 1.1939409563453297e-07 6.923017149728799 -0.2623381109209403 LYSVSYLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYSVSYLLK 9 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 21591000.0 8203100.0 11050000.0 2337900.0 False True 10754343.538933398 9401383.072562635 2095996.5347203545 1.0 0.8741940443437844 0.19489767340352535 23.358416127416945 -6.938105808403208 0.6769558707933254 1.0079324552386686 0.02148887246143493 0.997905127721357 0.016185369275089182 0.08864151486604258 0.05862510891485599 0.015537693174166374 0.05897026372022647 1.1531722729442737e-07 6.938105808403208 -0.9864435827772337 down LYSVSYLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYSVSYLLK 9 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 20856800.0 11551000.0 5237100.0 4068700.0 False True 11184319.827697719 7328301.341115708 3002985.411616379 1.0 0.6552299517550754 0.2684996010378345 23.41497418604933 -7.356593725507216 0.33334281563891976 1.0601932775605263 2.382813009604896e-16 0.9997145867969013 0.005047934652594088 0.11045591228086363 0.027628111112191878 0.014595435671994582 0.05454998491976222 4.399529909145263e-08 7.356593725507216 -1.060193277560526 down LYSVSYLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYSVSYLLK 9 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 22138400.0 5372400.0 7006100.0 9759900.0 False True 8150323.575050114 5755806.716090845 7830851.4870838635 1.0 0.7062059147824022 0.9608025270377948 22.95842590607322 -10.168941308443307 7.036801156377296 1.000000236269872 0.8335042213314146 0.3631452365363388 0.10393863171115504 3.852694232308754e-07 4.5499495641424916e-08 0.10063829062411998 0.03354604913707412 6.777330918332909e-11 10.168941308443307 -0.16649601493845734 LYSVSYLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYSVSYLLK 9 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 34422100.0 8203100.0 13158000.0 13061000.0 False True 11236007.750442134 12576636.05231268 9976260.79973865 1.0 1.1193153593025773 0.8878830471922811 23.421626188939836 -6.766585103847525 1.5876280537023535 1.0687340773963638 0.8867489491315552 0.7173000207175158 0.05024366019049909 0.27198266223415535 1.3524267047781988 0.024953496948769454 0.05958523937191509 1.7116497309231298e-07 6.766585103847525 -0.18198512826480862 LYSVSYLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYSVSYLLK 9 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 22326900.0 11551000.0 6557500.0 4218400.0 False True 9605168.296064263 6522173.445938168 5100447.936322132 1.0 0.6790275032047738 0.5310107828523994 23.195379461483608 -13.999999999999977 0.10382126544184286 2.5689111433689567 0.23362707024794646 0.9997744537651739 0.0029398942261159044 12.052485159024693 0.09670836353215759 4.014383547297363 0.26470894777892895 1.0000000000000532e-14 13.999999999999977 -2.3352840731210103 LYSVSYLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYSVSYLLK 9 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 28135700.0 5372400.0 15135000.0 7628300.0 False True 6954677.705836255 14292723.945265759 6240027.67296778 1.0 2.0551238389194557 0.897241818658433 22.72955222816567 -6.666877981099092 1.9482722608628973 1.675269511965253 0.9019629511371322 0.2653776433757181 0.44851650387295056 0.46831707302981335 3.4239633772527918 0.18552619049332306 0.4977366279374299 2.1533866628934375e-07 6.666877981099092 -0.7733065608281208 LYSVVSQLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYSVVSQLIR 10 0 Q93008;Q93008-3;O00507 Q93008 USP9X;USP9Y Probable ubiquitin carboxyl-terminal hydrolase FAF-X;Probable ubiquitin carboxyl-terminal hydrolase FAF-Y 0 3985800.0 1120700.0 1243200.0 1621900.0 False True 1535053.0757787304 1188271.3132873648 1238840.6240790226 1.0 0.774091353606491 0.8070343909447953 20.54985710820235 -10.586533138114694 9.58581052400238 1.0000227844567047 0.7905628723042989 0.9817821794911833 0.013448938676049977 6.549458576509279e-06 2.82485244583162e-07 0.013023292209785443 0.0043406262930422 2.5909967121375056e-11 10.586533138114694 -0.20945991215240578 LYTEK(ub)AYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYTEKAYK 8 1 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 1 4059420.0 935000.0 1195400.0 1929020.0 True False 1225794.0545528799 1017050.9796327055 1729423.5148664427 1.0 0.829707874544786 1.4108597675465693 20.22528518176796 -6.8282742753908785 1.3357565005356389 0.9088950072790933 1.425937214924793 0.9023484402540084 0.07622815000265389 0.18295213326019805 0.6390448966558112 0.04481662667753904 0.10313733067688327 1.4849975071532354e-07 6.8282742753908785 0.5170422076456997 LYTEK(ub)AYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYTEKAYK 8 1 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 1 3835700.0 1143400.0 1003000.0 1689300.0 True False 1107103.3928655179 1403503.1305759011 1246821.6520863043 1.0 1.2677254352398029 1.12620163583742 20.078358531650384 -10.145926908735545 4.050744030186918 0.9999331434641301 1.1969635354786803 0.7208704615865313 0.05777684933567599 40719935.74048098 49318597.89839711 32298.22907602116 0.021144158286477675 7.146165851092264e-11 10.145926908735545 0.1970303920145502 LYTEK(ub)AYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYTEKAYK 8 1 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 1 19034300.0 4019000.0 4709900.0 10305400.0 True False 6097116.828256729 3869381.5463833422 8268533.172982729 1.0 0.6346247997825663 1.3561382217022149 22.53969575939463 -6.769036994963559 1.5779325094352263 0.7901612876954294 1.3600642742558475 0.7268462312747959 0.15395161544985236 0.26803939383745384 1.3169258434320548 0.07690578414020953 0.1832453566657436 1.7020135178122575e-07 6.769036994963559 0.5699029865604182 LYTEK(ub)AYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYTEKAYK 8 1 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 1 4079850.0 935000.0 770060.0 2374790.0 True False 1280694.7674249245 736036.2029521138 1813913.5123352986 1.0 0.5747163349718776 1.4163511544460432 20.28849524329085 -6.769316357505225 1.577103784739822 0.7558665024078677 1.420963624163241 0.7279940724125249 0.17920305389302388 0.26750038703710516 1.3129783792903182 0.08957151808243914 0.2133485036648821 1.7009190394166776e-07 6.769316357505225 0.6650971217553734 LYTEK(ub)AYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYTEKAYK 8 1 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 1 7074430.0 1143400.0 3401100.0 2529930.0 True False 950787.7612085447 3382777.59923451 3058926.6659253417 1.0 3.5578682617187534 3.217254986577809 19.85876380708466 -10.302865470520972 5.83337051911912 0.999795209136352 3.387561624148291 0.9849652526318785 0.1390547872856239 0.00037038408993028324 4.4263689102259765e-05 0.1346497346643883 0.044879739613964444 4.978912906748316e-11 10.302865470520972 2.387766415011939 LYTEK(ub)AYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYTEKAYK 8 1 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 1 11336100.0 4019000.0 4069800.0 3247300.0 True False 5202674.7263338445 3843312.0523582753 2656324.720111725 1.0 0.7387184966426936 0.5105690553104307 22.31082208148708 -6.972715142803376 0.18199756179818943 1.1717705138257595 0.07133511610365185 0.9999965467905038 0.00037154060367026293 0.07543114710459539 0.005752572018532101 0.008632376411208868 0.02544979564097793 1.0648412270288109e-07 6.972715142803376 -1.1004353977221075 LYTLQDK(ub)AQVADVVVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYTLQDKAQVADVVVSR 17 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 14409100.0 3422500.0 3269800.0 7716800.0 True False 3313854.6108817835 4575448.191781737 5695538.580962288 1.0 1.3807027552618718 1.718705027752187 21.660078877749253 -6.972529604858167 0.18820050263586968 0.7654637766815352 2.3431605012938372 0.9999959790867531 0.0005886699629173537 0.07549010582135741 0.005991300237830911 0.012118136380318318 0.0370316538212425 1.0652962423922881e-07 6.972529604858167 1.5776967246123021 LYTLQDK(ub)AQVADVVVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYTLQDKAQVADVVVSR 17 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 50178300.0 6093500.0 8100800.0 35984000.0 True False 9244284.994521622 6655148.948160713 28871746.627652545 1.0 0.719920356426128 3.1231995383918405 23.14013030704459 -6.877859594644768 1.09162999970031 0.8308562376338319 3.2867037044246614 0.9719191959789785 0.17980795706485117 0.12954470814705105 0.2838661236219321 0.12711525622772643 0.3058029251857975 1.324769757776804e-07 6.877859594644768 2.4558474667908294 up LYTLQDK(ub)AQVADVVVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYTLQDKAQVADVVVSR 17 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 9977500.0 3290800.0 2183400.0 4503300.0 True False 4507497.690526141 2086930.1684617377 3439713.28837478 1.0 0.4629908458628937 0.7631092736008207 22.1038953217988 -10.159223249324189 5.515491714645029 1.0000089198506281 0.6130500597318077 0.6891007155347051 0.12252283506090583 1.3439042842415997e-05 2.048780040580632e-06 0.11863495813601774 0.039544074976722306 6.93069441691067e-11 10.159223249324189 -0.3869588601188204 LYTLQDK(ub)AQVADVVVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYTLQDKAQVADVVVSR 17 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 14434800.0 3422500.0 5270600.0 5741700.0 True False 2845960.392457794 5242206.231667813 6942262.9233787125 1.0 1.8419814434383615 2.4393392619857646 21.44048415318353 -7.77133933432892 0.13914899423057997 5.830496698504548e-18 3.816786253333337 0.9999762620801661 0.002876661476362445 0.1344191719363999 0.018623001174251974 0.1971291903478179 0.27316254647433524 1.6930144531643045e-08 7.77133933432892 3.816786253333337 LYTLVLTDPDAPSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYTLVLTDPDAPSR 14 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 166322000.0 48297000.0 51092000.0 66933000.0 False True 63317834.70881336 43469272.75505618 60007415.226672456 1.0 0.6865249412738618 0.9477174243660591 25.91610858443284 -10.029183723519592 6.585038535115338 1.000000074011909 0.8171211836923287 0.39527652524048484 0.10663138470440427 1.1597045729155789e-07 1.705515619921904e-08 0.10324543736301509 0.03441513142859902 9.350100447207853e-11 10.029183723519592 -0.18287889031958038 LYTLVLTDPDAPSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYTLVLTDPDAPSR 14 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 147554000.0 56012000.0 22872000.0 68670000.0 False True 54233929.71941863 32004908.875904296 50683266.94415827 1.0 0.5901270485373815 0.9345306011637022 25.692692374142645 -10.049741889280172 7.11616711836937 1.0000000410942438 0.7623288248505419 0.3883697930262502 0.1406021615893768 9.154197447172609e-08 1.225801662711753e-08 0.13613747988371344 0.04537915252303498 8.917807855153004e-11 10.049741889280172 -0.2376712162437019 LYTLVLTDPDAPSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYTLVLTDPDAPSR 14 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 173906000.0 18301000.0 134530000.0 21075000.0 False True 27763954.9823156 110522070.41231252 16909517.012499366 1.0 3.980775450857421 0.609045686152062 24.72670975903533 -6.67333463869037 1.9252675755395892 2.897100683711637 0.6223708060727913 0.29402011086039936 1.2651977712414877 0.4535090997212865 3.243831111057564 0.5284164536222671 1.4058320276792804 2.1216090599719727e-07 6.67333463869037 -2.274729877638846 LYTLVLTDPDAPSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYTLVLTDPDAPSR 14 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 184982000.0 48297000.0 53250000.0 83435000.0 False True 66153706.07734934 50897238.92579806 63729371.39776389 1.0 0.7693784965922716 0.9633530028272214 25.979318645955733 -10.086296864599909 6.184416436486481 1.0000002986737775 0.8663657498055507 0.38756524012743776 0.079189760563997 3.261269121836361e-07 4.80342867281066e-08 0.07667532734489015 0.025558385321208427 8.197909797181029e-11 10.086296864599909 -0.1336345488682268 LYTLVLTDPDAPSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYTLVLTDPDAPSR 14 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 106718000.0 56012000.0 22109000.0 28597000.0 False True 46576459.75232893 21989894.428707097 34576500.48241134 1.0 0.47212464291272266 0.7423599961498241 25.47309764957692 -10.296253391028134 4.988101681218608 1.000121271929077 0.6072423195311569 0.7379771636389343 0.11032312098250874 0.00014883387452600843 2.099838540420616e-05 0.10685267396853394 0.03560663418882621 5.055296224558071e-11 10.296253391028134 -0.39287895239792014 LYTLVLTDPDAPSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYTLVLTDPDAPSR 14 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 78544000.0 18301000.0 41194000.0 19049000.0 False True 23691005.266642373 38901517.68756372 15582277.459245594 1.0 1.6420374420471802 0.6577296861769685 24.49783608112778 -6.73070846792815 1.7208772481497192 1.3860731387021554 0.6582630831644781 0.5624646369367721 0.26988175556534033 0.33490197906119357 1.943365260233303 0.12426996365724767 0.30809334408527056 1.85905197591059e-07 6.73070846792815 -0.7278100555376773 LYTLVLTDPDAPSRK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYTLVLTDPDAPSRK 15 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 12135600.0 4648300.0 5533900.0 1953400.0 False True 6093966.314201225 4708263.690973255 1751280.9063359152 1.0 0.7726107182445752 0.2873794858784786 22.538950094542344 -6.95875753312837 0.4526039474930166 1.0152378776957607 0.02543241864301266 0.9997213068523342 0.004961586654856683 0.08014796868901969 0.02279400048368109 0.006511285797719025 0.04012164824053837 1.0996195863683517e-07 6.95875753312837 -0.989805459052748 down LYTLVLTDPDAPSRK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYTLVLTDPDAPSRK 15 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 12201200.0 2599700.0 1153000.0 8448500.0 False True 2517173.946503836 1613398.9128155697 6235584.40043281 1.0 0.6409564643144581 2.4772163278956403 21.26337348510292 -6.855958804388421 1.2059322494393243 0.8069202406695998 2.559535788606741 0.9485424662911193 0.18025586567578197 0.15102316498080753 0.41965086153808023 0.1167565194390534 0.2714309998650071 1.3932889590536517e-07 6.855958804388421 1.7526155479371415 up LYTLVLTDPDAPSRK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYTLVLTDPDAPSRK 15 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 15663800.0 4648300.0 2558000.0 8457500.0 False True 6366902.125584246 2444979.1018251902 6460012.687680088 1.0 0.3840139291603814 1.0146241547709198 22.602160156065235 -10.879373047299463 12.212140139121926 1.010115620736667 0.6993190419663321 0.23261670943944723 0.2574455465545333 0.06780711145112692 0.000669772011911614 0.2383823980416677 0.08309019286341444 1.320161164022098e-11 10.879373047299463 -0.31079657877033495 LYTLVLTDPDAPSRK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYTLVLTDPDAPSRK 15 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 7415700.0 2599700.0 1440200.0 3375800.0 False True 2161765.736237409 1432441.3567426815 4081664.172064352 1.0 0.6626256179061616 1.8881158599398284 21.043778760537197 -6.833298547006146 1.3130584999692858 0.8200979033182001 1.923382479457187 0.9123193856959694 0.1530501215092832 0.1767764907392811 0.5948946637393209 0.0914840436247063 0.21054121127883665 1.4679168408186878e-07 6.833298547006146 1.103284576138987 LYTLVLVLQPQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYTLVLVLQPQR 12 0 P36639-4;P36639-3;P36639-2;P36639;C9J361 P36639-4 NUDT1 7,8-dihydro-8-oxoguanine triphosphatase 0 13387800.0 7321700.0 3956000.0 2110100.0 False True 7089276.6411959585 5535651.4302674625 1557401.5083569 1.0 0.7808485562687253 0.2196841211283535 22.757206998002076 -7.015282134847475 0.5229312815591739 1.0087358328762819 4.450594971753626e-15 0.9994958131795394 0.007378508090472036 0.07480801022076887 0.029657769345393308 0.008508041106570038 0.042081044214494746 9.654234979933986e-08 7.015282134847475 -1.0087358328762774 down LYTLVLVLQPQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYTLVLVLQPQR 12 0 P36639-4;P36639-3;P36639-2;P36639;C9J361 P36639-4 NUDT1 7,8-dihydro-8-oxoguanine triphosphatase 0 101126000.0 34958000.0 26376000.0 39792000.0 False True 53033841.7721321 21668996.72337137 31927093.758546863 1.0 0.4085881014706701 0.6020135953138458 25.6604099253217 -10.30454754671243 4.759773145833484 1.0002421838919933 0.5053008483916267 0.8971357366933101 0.07896562719577441 0.00020303955977332577 2.9666298721392986e-05 0.07649502040719608 0.02548604658736361 4.959666258231424e-11 10.30454754671243 -0.49494133550036656 LYTLVLVLQPQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYTLVLVLQPQR 12 0 P36639-4;P36639-3;P36639-2;P36639;C9J361 P36639-4 NUDT1 7,8-dihydro-8-oxoguanine triphosphatase 0 10595400.0 1706200.0 3457600.0 5431600.0 False True 2337028.2483212897 3304831.799245811 4148767.947313402 1.0 1.4141171813475957 1.7752322635781157 21.15624374181322 -6.9727301786868665 0.1814867198338508 0.7262794290031013 2.47284974130531 0.999996591000015 0.0005847720756617146 0.07542634121828697 0.005733098961294866 0.013724824774714383 0.04034353001687318 1.0648043613716659e-07 6.9727301786868665 1.7465703123022087 LYTLVLVLQPQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYTLVLVLQPQR 12 0 P36639-4;P36639-3;P36639-2;P36639;C9J361 P36639-4 NUDT1 7,8-dihydro-8-oxoguanine triphosphatase 0 15711500.0 7321700.0 4431600.0 3958200.0 False True 6088317.956306279 4407726.091196273 4785841.319350997 1.0 0.7239645042898509 0.7860695439524185 22.537612273436352 -10.091693076475137 5.001390999662333 1.0000070200085047 0.7550170241201382 0.9540168006985323 0.025354276274890605 1.984696093066809e-06 3.604638752180372e-07 0.024549875745953492 0.008183057480154795 8.096679035351886e-11 10.091693076475137 -0.24498999588836656 LYTLVLVLQPQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYTLVLVLQPQR 12 0 P36639-4;P36639-3;P36639-2;P36639;C9J361 P36639-4 NUDT1 7,8-dihydro-8-oxoguanine triphosphatase 0 91812000.0 34958000.0 24987000.0 31867000.0 False True 45253820.12519997 23596451.48466173 26067532.983032174 1.0 0.5214245210543418 0.5760294470370303 25.43153624741415 -10.22018917280434 4.869267046123351 1.0000714116971325 0.548726984045709 0.9891381658637726 0.02229236768877398 1.7426961939575977e-05 2.7909384709456765e-06 0.02158792151790467 0.0071948307330507 6.02297176420906e-11 10.22018917280434 -0.4513444276514236 LYTLVTYVPVTTFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYTLVTYVPVTTFK 14 0 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2 H7C2W9 RPL31 60S ribosomal protein L31 0 227074000.0 78762000.0 124400000.0 23912000.0 False True 103257744.73229292 105840004.90740202 21437815.62010056 1.0 1.0250079079472818 0.2076146024269701 26.621674752538695 -6.899840707875364 0.9622552006685143 1.0341329274247908 0.12208665980961107 0.9864874453968695 0.044122063141095465 0.11152328633981873 0.178073587659805 0.03439951807782748 0.08943224525542837 1.2593872497711358e-07 6.899840707875364 -0.9120462676151797 down LYTLVTYVPVTTFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYTLVTYVPVTTFK 14 0 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2 H7C2W9 RPL31 60S ribosomal protein L31 0 346392000.0 142770000.0 109840000.0 93782000.0 False True 138237844.4983468 153699684.80803302 69217680.80030644 1.0 1.1118495471757093 0.500714410380829 27.042577386373 -6.859482921771137 1.1882950283301432 1.0606068060297622 0.47140444083793337 0.95301074172994 0.05759191376673593 0.14734005164259187 0.39562236095307834 0.03780794087380081 0.08820724294021177 1.382028751835296e-07 6.859482921771137 -0.5892023651918288 LYTLVTYVPVTTFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYTLVTYVPVTTFK 14 0 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2 H7C2W9 RPL31 60S ribosomal protein L31 0 288105000.0 78834000.0 113690000.0 95581000.0 False True 119596941.53739503 93401131.23597568 76689373.45535952 1.0 0.7809658845395426 0.6412318949760152 26.833605254945518 -9.547542341265846 0.0710173557673009 1.7884633985209415 3.5053005388522023e-13 0.9999853214894361 0.0005656716634347379 1.0321443928437661 0.028611954263049025 0.4320487007231699 0.28547887432952146 2.834377284197901e-10 9.547542341265846 -1.7884633985205909 LYTLVTYVPVTTFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYTLVTYVPVTTFK 14 0 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2 H7C2W9 RPL31 60S ribosomal protein L31 0 348582000.0 78762000.0 118190000.0 151630000.0 False True 107882439.86301802 112967974.99793564 115818116.9178753 1.0 1.0471396006743534 1.0735585611980363 26.684884814061586 -13.585995094003007 0.07047210678399847 0.7409606831312839 1.1703325025966016 0.9999288923421285 0.00025649246368650774 10.804109884238189 0.06835054428230004 0.47941086338357713 0.08601704878852577 2.594208667368055e-14 13.585995094003007 0.42937181946531766 LYTLVTYVPVTTFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYTLVTYVPVTTFK 14 0 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2 H7C2W9 RPL31 60S ribosomal protein L31 0 282340000.0 142770000.0 71516000.0 68054000.0 False True 118719580.78340364 71130729.1131855 82283776.75385608 1.0 0.599149092709138 0.6930935588795384 26.822982661807277 -10.018639412884143 5.924734294817307 1.0000005426922838 0.6461213257942985 0.9497974370517218 0.03835266771276464 2.7494688689990473e-07 4.5577825925767426e-08 0.03713486782667728 0.012378270277823844 9.579891428196032e-11 10.018639412884143 -0.3538792168979853 LYTLVTYVPVTTFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYTLVTYVPVTTFK 14 0 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2 H7C2W9 RPL31 60S ribosomal protein L31 0 281816000.0 78834000.0 131230000.0 71752000.0 False True 102052167.05046082 123926935.139559 58693872.23769171 1.0 1.2143488837261238 0.5751359714749602 26.604731577037967 -6.816290634095862 1.387960630675069 1.115985144887045 0.5622747752827977 0.875599255651133 0.09369006104586426 0.19835617078538056 0.7518407669796464 0.05305896153724544 0.12242302643265579 1.526544138136105e-07 6.816290634095862 -0.5537103696042474 LYTVEYLSNMVGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYTVEYLSNMVGGR 14 0 Q13867;K7ESE8;K7ES02;J3KSD8 Q13867 BLMH Bleomycin hydrolase 0 6448000.0 1411600.0 3149400.0 1887000.0 False True 1850621.269953845 2679521.796265048 1691751.3413821403 1.0 1.4479039227361068 0.9141531921462963 20.81957824688532 -6.6840888253137205 1.8869965495336793 1.2823356429570862 0.916095122546507 0.34314618826705157 0.18966298345015947 0.42947422386613027 2.959964725169071 0.08054134491599312 0.21134435303000804 2.069717990541495e-07 6.6840888253137205 -0.3662405204105792 LYTVEYLSNMVGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYTVEYLSNMVGGR 14 0 Q13867;K7ESE8;K7ES02;J3KSD8 Q13867 BLMH Bleomycin hydrolase 0 14526700.0 1411600.0 5146500.0 7968600.0 False True 1933506.66705564 4919110.612800369 6086580.798468525 1.0 2.544139462570994 3.147949216920581 20.882788308408212 -9.563136857068875 0.26911748918027617 1.5630805520411216e-25 3.4573121469677504 0.9989472432009512 0.029346716057926013 0.9568071599088961 0.10968208375752277 1.0581317885010495 0.24211934490688272 2.7344069104187204e-10 9.563136857068875 3.4573121469677504 LYTVEYLSNMVGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYTVEYLSNMVGGR 14 0 Q13867;K7ESE8;K7ES02;J3KSD8 Q13867 BLMH Bleomycin hydrolase 0 18352400.0 12364000.0 2974800.0 3013600.0 False True 10281213.818071047 2958774.1619484345 3643729.8266879315 1.0 0.28778451788911025 0.3544065799199151 23.29350726589649 -10.195797661183535 5.280974299282622 1.0000384447249377 0.3210955489043118 0.9928294123888061 0.027198342931956276 1.231174803491247e-05 1.874885117808775e-06 0.02633616782958658 0.008778227434890713 6.370922745565588e-11 10.195797661183535 -0.678942895820626 LYVELHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYVELHR 7 0 Q04323;E9PJ81;E9PRQ7;Q04323-2;A0A087WTZ5 Q04323 UBXN1 UBX domain-containing protein 1 0 11265600.0 4232500.0 4096100.0 2937000.0 False True 5548848.487588302 3484977.846472742 2633107.413693352 1.0 0.6280542448163725 0.474532224043079 22.403756979775963 -13.999999999999998 0.12152877893061026 2.770943780233532 0.23447408991858656 0.9996854742374706 0.0039125314009161635 11.958180694720504 0.10748251265743188 5.104644799665229 0.2130538554600034 1.0000000000000041e-14 13.999999999999998 -2.5364696903149455 LYVELHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYVELHR 7 0 Q04323;E9PJ81;E9PRQ7;Q04323-2;A0A087WTZ5 Q04323 UBXN1 UBX domain-containing protein 1 0 7892700.0 4232500.0 1534800.0 2125400.0 False True 5797369.629011756 1466987.4610951128 1623424.2939870225 1.0 0.25304363098634813 0.28002773634838224 22.466967041298854 -10.471319291813337 6.089177587458951 1.0004427395004243 0.26653568366740277 0.9989859046034621 0.011016214883747455 6.625006528296675e-05 5.7520236905106985e-06 0.010672428713546211 0.003555468065249641 3.378163834400665e-11 10.471319291813337 -0.7339070558330215 LYVELHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYVELHR 7 0 Q04323;E9PJ81;E9PRQ7;Q04323-2;A0A087WTZ5 Q04323 UBXN1 UBX domain-containing protein 1 0 10930000.0 3256800.0 4972300.0 2700900.0 False True 4215991.801125672 4695587.13399702 2209363.9135742774 1.0 1.1137562299678325 0.5240436931078415 22.007440630680982 -6.856705972839907 1.20227998823908 1.061256251972818 0.49723398169155786 0.9495080473051097 0.05739790940217784 0.150233626018723 0.414535626683796 0.03728233346258999 0.08672966096870965 1.3908939791170555e-07 6.856705972839907 -0.5640222702812601 LYVGSLHFNITEDMLR ddPTM_RPMI8226_Bortezomib_8h_R1 2 LYVGSLHFNITEDMLR 16 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;A0A0U1RQW2;G3V5Z6;Q86U06-4;Q86U06-5;Q86U06-2;Q86U06;G3XAP0;Q86U06-3;G3V546;H0YJJ3 Q14498-3;Q86U06-4 RBM39;RBM23 RNA-binding protein 39;Probable RNA-binding protein 23 0 301638000.0 12961000.0 179221000.0 109456000.0 False True 19662784.576022737 147237612.28993556 87821973.62373096 1.0 7.488136368512147 4.466405726217595 24.22896430987517 -9.543287440324422 9.916278094502529 0.9999065441905954 5.977271047364873 0.7834330942488332 1.2336163701390204 0.0 1.3355875563871666e-16 1.1944439137561376 0.3981479712520457 2.8622829242800364e-10 9.543287440324422 4.977364503174277 LYVGSLHFNITEDMLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 LYVGSLHFNITEDMLR 16 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;A0A0U1RQW2;G3V5Z6;Q86U06-4;Q86U06-5;Q86U06-2;Q86U06;G3XAP0;Q86U06-3;G3V546;H0YJJ3 Q14498-3;Q86U06-4 RBM39;RBM23 RNA-binding protein 39;Probable RNA-binding protein 23 0 133987100.0 12961000.0 69395000.0 51631100.0 False True 16778269.99950557 65533107.246892355 42234769.57982341 1.0 3.90583220134278 2.517230297346986 24.00009063196762 -9.583002954872079 13.639085353470398 0.9999941214961551 3.211516657597646 0.771791990500496 0.5668943535765041 0.0 0.0 0.5488930977803231 0.18296436592677434 2.612143581720264e-10 9.583002954872079 2.211522536101491 LYVNSEK(ub)QLIQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYVNSEKQLIQR 12 1 F8W9S7;Q14C86-3;Q14C86-4;Q14C86-5;Q14C86-2;Q14C86;Q14C86-6;B0QZ65;B4DGD8;C9IZ08;C9IZX9 F8W9S7 GAPVD1 GTPase-activating protein and VPS9 domain-containing protein 1 1 10087500.0 4242200.0 5845300.0 0.0 True False 3527577.2613248946 5813810.208698791 0.0 1.0 1.6481028700460636 0.0 21.750246250533564 -6.814275319121861 1.4913182437070658 1.356668945021594 1.5686156388320972e-21 0.8317245455919006 0.27809559980733317 0.21233867569137654 0.9448248441241388 0.1486931751497004 0.3289662698597575 1.5336444272592567e-07 6.814275319121861 -1.356668945021594 LYVPVK(ub)EYPDFNFVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYVPVKEYPDFNFVGR 16 1 Q96PU8-9;Q96PU8-8;Q96PU8-6;Q96PU8;Q96PU8-5;Q96PU8-3;F5GXS8;F5GYM3;F5H8C8;F5H5U6 Q96PU8-9 QKI Protein quaking 1 13594400.0 4411300.0 3042300.0 6140800.0 True False 4271265.696123535 4257106.2553849155 4532340.2599488385 1.0 0.9966849543563937 1.0611234660635247 22.026232213629985 -6.894773590186119 0.9936938255038117 0.9969233651529338 1.0672136723998118 0.9837825836029794 0.0037728178742209018 0.11535613295386336 0.19989662680481968 0.0028731893126991955 0.007297779783970138 1.274167166743739e-07 6.894773590186119 0.07029030724687801 LYVYDLSK(ub)GLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYVYDLSKGLAR 12 1 Q6ICB0 Q6ICB0 DESI1 Desumoylating isopeptidase 1 1 27932700.0 8369100.0 11826000.0 7737600.0 True False 10971971.146479681 10061606.89738695 6936987.376300193 1.0 0.9170281951220024 0.6322462284751725 23.387319397590804 -6.948392995860213 0.5762264626285296 1.0034544566651142 0.5318254644870217 0.999068981036951 0.004805426699880387 0.08413775423789677 0.03868459411145609 0.005055626250358192 0.023765415716740894 1.1261779093396361e-07 6.948392995860213 -0.4716289921780925 LYVYDLSK(ub)GLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYVYDLSKGLAR 12 1 Q6ICB0 Q6ICB0 DESI1 Desumoylating isopeptidase 1 1 52838000.0 15411000.0 24305000.0 13122000.0 True False 14921786.24055489 34010113.24890058 9684954.548438106 1.0 2.2792253354003185 0.6490479351671744 23.830916910672105 -6.6973946895536445 1.8399658249532678 1.796352111955934 0.6540939754698963 0.4053289222951737 0.5402365442360131 0.4009569887272525 2.6371325986035785 0.23439159371835314 0.6047831462587938 2.0072677658709222e-07 6.6973946895536445 -1.1422581364860376 LYVYDLSK(ub)GLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYVYDLSKGLAR 12 1 Q6ICB0 Q6ICB0 DESI1 Desumoylating isopeptidase 1 1 94441000.0 18582000.0 32263000.0 43596000.0 True False 28190252.526167355 26505415.578030467 34979231.491194405 1.0 0.940233350284005 1.2408271780724645 24.748693065731704 -6.855036589057031 1.2105738927764387 0.9679115311212069 1.254061035458495 0.9473127320939765 0.02982278828550378 0.15200524143860286 0.4261520603926393 0.0192493008863301 0.044711008886192685 1.3962507227907494e-07 6.855036589057031 0.28614950433728803 LYVYDLSK(ub)GLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYVYDLSKGLAR 12 1 Q6ICB0 Q6ICB0 DESI1 Desumoylating isopeptidase 1 1 33061100.0 8369100.0 11410000.0 13282000.0 True False 11463382.436423454 10905868.472175693 10145065.151376512 1.0 0.9513656665177347 0.8849975308458562 23.450529459113696 -6.966782792555683 0.32603798129777084 1.0084685564910014 0.8257348766347062 0.9999452793758119 0.0003486277059460817 0.0773613785547725 0.01275590320957775 0.0009825635527296527 0.005807625508683978 1.0794864801238108e-07 6.966782792555683 -0.18273367985629518 LYVYDLSK(ub)GLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYVYDLSKGLAR 12 1 Q6ICB0 Q6ICB0 DESI1 Desumoylating isopeptidase 1 1 42919200.0 15411000.0 18099000.0 9409200.0 True False 12814929.323058294 18001497.094629798 11376620.216774657 1.0 1.4047285506474978 0.8877630090635269 23.61132218610638 -6.697806368644839 1.8382285590080782 1.2518448484218676 0.8893367091986668 0.4074515604801341 0.17090852014296246 0.4000669592690211 2.6265409085598512 0.07420931173485806 0.19139816638026053 2.005365925833073e-07 6.697806368644839 -0.3625081392232008 LYVYDLSK(ub)GLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYVYDLSKGLAR 12 1 Q6ICB0 Q6ICB0 DESI1 Desumoylating isopeptidase 1 1 89635000.0 18582000.0 35070000.0 35983000.0 True False 24054765.30598048 33118323.670992345 29434463.216758586 1.0 1.37678847620095 1.2236437496831702 24.519819387824153 -10.253543662516034 5.448213772463569 0.9999742616738905 1.3002161129420784 0.836705993416109 0.06252107279450402 1.9547914422995526e-05 2.6782002036751306e-06 0.060540951981693535 0.020178589476668597 5.577715228370993e-11 10.253543662516034 0.3002418512681879 LYYAMK(ub)GAGTDDSTLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYYAMKGAGTDDSTLVR 17 1 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 1 11040700.0 3724300.0 4141500.0 3174900.0 True False 3606074.1350787496 5795222.54763719 2343298.445041616 1.0 1.6070724922882467 0.6498198199107305 21.781997625886735 -6.735348394040005 1.7038216299838933 1.3631390676068824 0.6498186266030324 0.583852160158515 0.2551092046418044 0.3262931979833048 1.858013735001702 0.11854276226379136 0.2923811919312472 1.8392959135688315e-07 6.735348394040005 -0.7133204410038501 LYYAMK(ub)GAGTDDSTLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYYAMKGAGTDDSTLVR 17 1 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 1 4397400.0 0.0 2866800.0 1530600.0 True False 0.0 2740135.2967601456 1169103.803696499 0.0 LYYAMK(ub)GAGTDDSTLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYYAMKGAGTDDSTLVR 17 1 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 1 11425200.0 3724300.0 4744200.0 2956700.0 True False 3096920.4644647352 4718642.052950032 3574932.2997638034 1.0 1.5236561955960957 1.154350697986584 21.56240290132101 -9.970585583424059 8.318498666300222 0.9999999990731248 1.3390034467913399 0.5290806934254202 0.15076833805798937 2.618041212675558e-09 5.22999102408196e-10 0.14598081560849066 0.048660271869496875 1.070075489721596e-10 9.970585583424059 0.3390034477182151 LYYAMK(ub)GAGTDDSTLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYYAMKGAGTDDSTLVR 17 1 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 1 27142500.0 4521800.0 14961000.0 7659700.0 True False 5853559.238003576 14128407.198224045 6265713.195158988 1.0 2.4136438402291973 1.0704108287620204 22.480882686938564 -6.634147537122591 2.0651644546498167 1.9284829141585749 1.075866358514222 0.13271566204714036 0.6057401812569403 0.5482779906330739 4.461370811532128 0.2394394927902777 0.6709992675310786 2.3219478577092895e-07 6.634147537122591 -0.8526165556443528 LYYEGLQDK(ub)LAQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 LYYEGLQDKLAQIR 14 1 O14964;O14964-2;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 48342300.0 8311300.0 22106000.0 17925000.0 True False 10896194.786743702 18807870.9685131 16070292.948741345 1.0 1.726095332968417 1.4748536772022875 23.377321063364075 -10.347668508712431 5.406565877013763 0.9998215069167367 1.6004745050853664 0.8839410314449772 0.10256897645988247 0.00022074339650821577 2.6633758516154408e-05 0.09934100747237178 0.03310399480554824 4.490880421637963e-11 10.347668508712431 0.6006529981686297 LYYEGLQDK(ub)LAQIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 LYYEGLQDKLAQIR 14 1 O14964;O14964-2;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 162992500.0 37981000.0 40042700.0 84968800.0 True False 36775313.94474828 56031958.92992194 62712922.270639226 1.0 1.523629655863852 1.705299439859574 25.132234321792204 -11.360762827105225 0.19333956718270193 2.502282799541875e-15 1.8532245179299724 0.9994109884807632 0.007256732303959476 3.805065862433277 0.11377343371670405 1.7402037172766847 0.11971937592254342 4.357497763658056e-12 11.360762827105225 1.85322451792997 LYYEGLQDK(ub)LAQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYYEGLQDKLAQIR 14 1 O14964;O14964-2;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 420170500.0 66735500.0 188894000.0 164541000.0 True False 101242632.51856846 155184389.86444166 132019399.22911778 1.0 1.5327968663396814 1.3039901861985335 26.59324168521314 -10.13894090423268 4.646205178391007 0.9999582240799934 1.4183935262748677 0.8167934491554496 0.09340993603404135 4.042626170348656e-05 7.492221116561372e-06 0.0904527936188611 0.030147927216394206 7.262047675975298e-11 10.13894090423268 0.41843530219487435 LYYEGLQDK(ub)LAQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 LYYEGLQDKLAQIR 14 1 O14964;O14964-2;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 76270300.0 8311300.0 25581000.0 42378000.0 True False 11384212.214437203 24450746.834945317 32369189.202306412 1.0 2.147776796003278 2.8433402850007075 23.440531124886967 -8.673537705095557 0.18641913034465174 2.044899279552607e-15 3.7276539012521193 0.999728411128034 0.012525610952670317 0.24935363414426787 0.05283295930431859 0.5223410275522733 0.3816800531028763 2.1206172748215763e-09 8.673537705095557 3.727653901252117 LYYEGLQDK(ub)LAQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 LYYEGLQDKLAQIR 14 1 O14964;O14964-2;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 156288400.0 37981000.0 75408500.0 42898900.0 True False 31582884.343590777 75002259.44308476 51868861.64789717 1.0 2.374775483680775 1.6423092040490943 24.91263959722648 -10.244701684563072 5.62603761780802 0.9999432017942037 2.0085423438649492 0.7165414412184452 0.29902810648215633 0.0002130586509814516 2.8602419480249014e-05 0.28954886450044026 0.09651090637109673 5.6924380826318584e-11 10.244701684563072 1.0085991420707456 LYYEGLQDK(ub)LAQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 LYYEGLQDKLAQIR 14 1 O14964;O14964-2;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 321500500.0 66735500.0 180841000.0 73924000.0 True False 86390420.303372 170777039.37798482 60470590.5242938 1.0 1.976805284408589 0.6999687038440477 26.36436800730559 -6.702292888145082 1.8229783847840362 1.6051946621551945 0.7036338713055854 0.42836809648954766 0.41215120191142085 0.39075515648176373 2.526247522747115 0.18027146806425354 0.4622538637250332 1.9847559467413898e-07 6.702292888145082 -0.901560790849609 LYYGLSEGEAAGRPAGPDPLDPTDLNGAHFDPEVYLDK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYYGLSEGEAAGRPAGPDPLDPTDLNGAHFDPEVYLDKLR 40 2 Q9UID3;E9PKX7;E9PRV0;E9PQN6;E9PQD5 Q9UID3 VPS51 Vacuolar protein sorting-associated protein 51 homolog 1 70291800.0 5712800.0 14925000.0 49654000.0 True False 8666735.261623554 12261517.140442748 39839865.135878645 1.0 1.4147792415832692 4.596871132350174 23.047057205345553 -6.930884246377601 0.739498445939538 0.9531631147273553 5.265094638679923 0.996709191951361 0.09217295941880449 0.09218126338115913 0.07544999645396068 0.08442003790215773 0.28653718478404955 1.172507835425905e-07 6.930884246377601 4.311931523952567 up LYYQQLK(ub)MK ddPTM_RPMI8226_Bortezomib_8h_R1 1 LYYQQLKMK 9 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 13479300.0 4598100.0 5096400.0 3784800.0 True False 6975653.866137655 4186907.6016450566 3036732.6210632278 1.0 0.6002172243622664 0.435333042512993 22.73389702429053 -13.999999999929244 0.12164876503671905 2.903349123392897 0.17792059658093026 0.9996848911488803 0.004208473481905322 11.957725390202564 0.10755010845315291 5.490679719441502 0.22845838611621164 1.0000000001629214e-14 13.999999999929244 -2.725428526811967 MAAAGGTVSGPSSACK(ub)PGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MAAAGGTVSGPSSACKPGR 19 1 Q9ULT8;A0A087X2H1;G3V4V5;A0A087WVU6 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 7366310.0 2780300.0 2282900.0 2303110.0 True False 2692040.8983592773 3194473.875166227 1699856.3991810158 1.0 1.1866364575341959 0.6314378062447082 21.360268897330318 -6.8160605685608076 1.3889913035385852 1.1010144645292514 0.6203274628569746 0.8750342399909488 0.0815463070034563 0.19865955182416264 0.7541719421111348 0.046148603872911226 0.10648477343301556 1.5273530322152904e-07 6.8160605685608076 -0.48068700167227685 MAAAGGTVSGPSSACK(ub)PGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MAAAGGTVSGPSSACKPGR 19 1 Q9ULT8;A0A087X2H1;G3V4V5;A0A087WVU6 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 29493200.0 8512200.0 10357000.0 10624000.0 True False 12913629.725177124 8508712.430389654 8524161.743335385 1.0 0.6588939447288472 0.6600903018549625 23.622391230348637 -10.428796828362481 5.940704622479943 1.0001376505149557 0.6594921232919048 0.9999907405480813 0.0004884107515213388 8.907926262468979e-07 8.565048326070526e-08 0.00047309115848089467 0.00015763389222915974 3.725659592929308e-11 10.428796828362481 -0.34064552722305097 MAAAGGTVSGPSSACK(ub)PGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MAAAGGTVSGPSSACKPGR 19 1 Q9ULT8;A0A087X2H1;G3V4V5;A0A087WVU6 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 9652700.0 2780300.0 2705500.0 4166900.0 True False 2311942.6381739685 2690924.934500294 5038179.524431224 1.0 1.1639237453683777 2.179197459851559 21.140674172764594 -6.935166904894043 0.7030908989613893 0.9871148587146712 2.417991152306376 0.9974598147856956 0.026286404103871428 0.09004224903901649 0.06517901847765203 0.024732584360892682 0.08939944930571096 1.1610023401231157e-07 6.935166904894043 1.430876293591705 up MAAAGGTVSGPSSACK(ub)PGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MAAAGGTVSGPSSACKPGR 19 1 Q9ULT8;A0A087X2H1;G3V4V5;A0A087WVU6 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 26990300.0 8512200.0 11986000.0 6492100.0 True False 11019210.700547125 11318968.563459208 5310604.414571277 1.0 1.027203206387296 0.481940545370241 23.393517552441086 -6.89516191316484 0.9913666820030177 1.0257762595854123 0.4300152547507281 0.9840010855635665 0.03173217175910445 0.11505401467223367 0.19819169903088382 0.024208555993671027 0.06158752910573085 1.2730283835691923e-07 6.89516191316484 -0.5957610048346842 down MAADDVEEYMIERPEPEFQDLNEK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MAADDVEEYMIERPEPEFQDLNEKAR 26 2 Q9BUL8;C9J363;C9J5C3;C9J6F3;C9JND6;H7C5M9;C9JSA3 Q9BUL8 PDCD10 Programmed cell death protein 10 1 13922900.0 3108300.0 2969800.0 7844800.0 True False 2584689.1710377117 2953801.097940854 9485111.409743005 1.0 1.1428070852925614 3.6697300070069483 21.301559365003627 -6.918536298018214 0.8355245176685532 0.9412487388643327 4.063790836120558 0.9937642512651351 0.09683295023658342 0.09904069400708511 0.11013815264045478 0.08279104809452051 0.24462728893603292 1.2063232603592066e-07 6.918536298018214 3.122542097256225 up MAAETDPHK(ub)SSEITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MAAETDPHKSSEITK 15 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 17799200.0 5335000.0 6197500.0 6266700.0 True False 6994236.66421349 5272857.157665784 5618281.998431089 1.0 0.7538860079820766 0.8032730758422044 22.737735182704746 -10.634586510127754 6.559671790631979 1.0008876161253928 0.778579541912141 0.9640298079234186 0.02016218602491997 0.0002627279878983983 1.463553612144563e-05 0.019596695298314384 0.0065073175581375885 2.3196020819315083e-11 10.634586510127754 -0.22230807421325183 MAAETDPHK(ub)SSEITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MAAETDPHKSSEITK 15 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 10526200.0 2999400.0 3183900.0 4342900.0 True False 2904185.6887885495 4455247.873819153 3205364.205792704 1.0 1.534078172417967 1.1037049793912415 21.469702269121306 -13.371118619585584 11.440714399582635 1.0686228657374324 1.2870056738184914 0.0 0.24291028587094057 0.0 0.0 0.0 0.06647899681063196 4.2548218459368565e-14 13.371118619585584 0.21838280808105903 MAAETDPHK(ub)SSEITK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MAAETDPHKSSEITK 15 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 42892000.0 9907700.0 15655100.0 17329200.0 True False 15030705.2498928 12861325.091145426 13904076.024341818 1.0 0.8556701017896119 0.9250448194665373 23.841409367188543 -10.21463878924071 4.736370972988055 1.0000209033860055 0.8903574606276526 0.7690736464275023 0.028322109894468813 6.252779036168282e-06 1.0367752156657973e-06 0.027427991877714903 0.009140921662355443 6.100440712437595e-11 10.21463878924071 -0.10966344275835282 MAAETDPHK(ub)SSEITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MAAETDPHKSSEITK 15 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 13885000.0 5335000.0 4742500.0 3807500.0 True False 7307493.672953979 4532960.668649712 2908246.917923964 1.0 0.6203167421720543 0.3979814486446671 22.800945244227638 -9.284553371348338 0.14131875997372667 1.571786167309224 4.9303074744079936e-09 0.9998478322851602 0.003066083174602707 0.7250057824626476 0.05134799145587626 0.3563154399493384 0.18787578611846648 5.193338475731295e-10 9.284553371348338 -1.5717861623789164 MAAETDPHK(ub)SSEITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MAAETDPHKSSEITK 15 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 12449100.0 2999400.0 5877200.0 3572500.0 True False 2494133.995949714 5845538.35706714 4319493.232626303 1.0 2.343714638652075 1.7318609343526992 21.250107544555583 -10.039914689751521 5.4493734772365725 0.9999939152335094 2.0377877865033094 0.7932107599104243 0.24978822879744397 1.8465547197725235e-05 3.2538784979155e-06 0.24185782745550258 0.08061880418379275 9.121900069869308e-11 10.039914689751521 1.0377938712698 MAAETDPHK(ub)SSEITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MAAETDPHKSSEITK 15 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 24757900.0 6829200.0 10258000.0 7670700.0 True False 8840534.023657406 9687133.282493288 6274711.308028517 1.0 1.0957633618704898 0.7097660945862877 23.07570208939476 -6.84106241987345 1.2776310946722713 1.0509361518436766 0.6968153497866862 0.9262355862161382 0.04457267562709694 0.1675641232672067 0.530887149058447 0.027352410454048688 0.06302734894628692 1.4419080954051448e-07 6.84106241987345 -0.35412080205699037 MACEALK(ub)HPK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MACEALKHPK 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 84905400.0 18237400.0 32464300.0 34203700.0 True False 23909408.01123282 27620752.984850284 30664629.22905794 1.0 1.1552252975846933 1.2825340223669055 24.511075074067364 -6.973392103562408 0.15731309143237468 0.8663032152223037 1.5748258242615965 0.9999982015245049 0.0001548285954712423 0.07521663800064858 0.004842958490246333 0.00604674425346128 0.015431353676334303 1.0631826883490287e-07 6.973392103562408 0.7085226090392928 MACEALK(ub)HPK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MACEALKHPK 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 31186310.0 17211010.0 4410700.0 9564600.0 True False 16664655.908380575 6171915.511496647 7059344.328150518 1.0 0.3703596129094283 0.4236117665412106 23.990288193216976 -10.45706806891962 9.439269982872426 1.0000045232076211 0.3969856915487999 0.9941850279995041 0.021740100683694155 2.0694415823389194e-06 1.1901463263696269e-07 0.021049919700396953 0.007016587324401683 3.4908559744114134e-11 10.45706806891962 -0.6030188316588212 MACEALK(ub)HPK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MACEALKHPK 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 102704100.0 24667200.0 18273800.0 59763100.0 True False 37421945.81387766 15012697.616148945 47950897.089902766 1.0 0.4011736239161993 1.2813576645210287 25.157381239974832 -6.723512365013008 1.7466901783930082 0.6370569043975955 1.2802640159560115 0.5290502101567564 0.2518855078555976 0.3485286903905916 2.07992374093359 0.11442105731251925 0.28605841994001585 1.8901124160953076e-07 6.723512365013008 0.6432071115584159 MACEALK(ub)HPK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MACEALKHPK 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 83144700.0 18237400.0 28867000.0 36040300.0 True False 24980259.627203543 27591560.489596486 27528323.4132777 1.0 1.1045345765561714 1.102003094607524 24.574285135590255 -10.133791955719476 4.189376325851927 0.9999757291564173 1.1032688355939235 0.9995495046882316 0.0010334732263750305 2.3434200564377825e-07 4.845315691932039e-08 0.0010008912602066872 0.0003335520433340637 7.348658137212723e-11 10.133791955719476 0.10329310643750622 MACEALK(ub)HPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MACEALKHPK 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 41551080.0 14149700.0 7116280.0 20285100.0 True False 11766102.487994159 7077943.187169017 24526620.622294698 1.0 0.6015537595725667 2.084515297000095 23.48813317214661 -6.835181017392463 1.3045366697134084 0.7877337067802372 2.1288332461839286 0.9158571070463315 0.18177215605293226 0.1745015208091148 0.5789255029710222 0.1093373436490228 0.2516660008991178 1.4615678543804358e-07 6.835181017392463 1.3410995394036913 up MACEALK(ub)HPK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MACEALKHPK 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 67701600.0 24667200.0 12303900.0 30730500.0 True False 31932176.66320531 11619177.149002647 25137864.321557403 1.0 0.36387050189382014 0.7872267708741311 24.92850756206728 -10.07203319402879 5.990974686203742 1.000001170583205 0.5755486363840931 0.5726934196704838 0.17283447306843816 2.7023718481989165e-06 4.1873475890575964e-07 0.1673467202431446 0.05578208632037318 8.471626612652298e-11 10.07203319402879 -0.4244525341991119 MADVSAEEKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 MADVSAEEKK 10 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 12948800.0 3091000.0 5406400.0 4451400.0 True False 2992877.896927857 7565203.714003541 3285444.8008624716 1.0 2.5277355022632584 1.0977543735529371 21.513101990462214 -6.630557895687495 2.0780189199489127 2.006097704853777 1.1034862988862424 0.11951223588475557 0.6552279398737314 0.5576700898679978 4.589643889944151 0.25780000922372337 0.7259960022820848 2.34121934700614e-07 6.630557895687495 -0.9026114059675348 MADVSAEEKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MADVSAEEKK 10 1 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 10549680.0 3620820.0 3740560.0 3188300.0 True False 3010872.2595234592 3720408.8608369697 3854958.7889663964 1.0 1.2356581548982124 1.2803461776809268 21.521750070325535 -13.130887066644688 0.24574200238187657 4.882738576864596e-15 1.2996574565960453 0.9994817757891928 0.0027996699633420323 9.08317477299549 0.1527995191756178 4.461435292713663 0.02112799728509488 7.397976260314823e-14 13.130887066644688 1.2996574565960404 MAEEK(ub)LTHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MAEEKLTHK 9 1 P16949;P16949-2 P16949 STMN1 Stathmin 1 1967940.0 648320.0 543470.0 776150.0 True False 627739.4364724254 760480.4051586097 572853.0309991031 1.0 1.2114587055930734 0.9125649875022098 19.259806320630403 -6.716643083532022 1.7713893423589275 1.1291068497052448 0.9131158495899768 0.4966541860248901 0.08902100389122028 0.3618697883233274 2.217227772184195 0.03993191595980389 0.1006421997783604 1.9202462093520328e-07 6.716643083532022 -0.21599100011526795 MAEEK(ub)LTHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MAEEKLTHK 9 1 P16949;P16949-2 P16949 STMN1 Stathmin 1 2011070.0 648320.0 996730.0 366020.0 True False 539106.8054457955 991360.4176545846 442553.08971473254 1.0 1.8388942740851022 0.8209005808204902 19.04021159606468 -6.687836966626492 1.8745802836897827 1.5270091638713934 0.8245521791472041 0.3601380877570406 0.3549521663503522 0.4213153156882849 2.868879009339434 0.1515906935215665 0.39576266037674207 2.0519323259940916e-07 6.687836966626492 -0.7024569847241893 MAESMLAILCHILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MAESMLAILCHILR 14 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 481105000.0 223880000.0 98145000.0 159080000.0 False True 339642327.82038254 80630257.93961504 127637768.27275896 1.0 0.23739755423610154 0.3758005343205023 28.3394410246189 -9.84398935606903 6.388640548754857 1.0000000285527688 0.306599044359105 0.9709867368757985 0.056502780015029855 2.3063737277389267e-08 4.08335506286208e-09 0.05470858476382629 0.018236193834316877 1.4322230005621324e-10 9.84398935606903 -0.6934009841936638 MAESMLAILCHILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MAESMLAILCHILR 14 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 474260000.0 223880000.0 116350000.0 134030000.0 False True 289817073.3345663 109875020.22013019 109637915.26393439 1.0 0.37911852105859173 0.378300401706727 28.11056734671135 MAILQIMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MAILQIMK 8 0 Q13263;Q13263-2;M0R3C0 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 27348500.0 7268400.0 9264100.0 10816000.0 False True 9528942.787285736 7881932.391178972 9696864.07439811 1.0 0.8271570694805372 1.0176222368903745 23.183884728879384 -11.789253016336543 15.927037382582204 0.9295617734627593 0.9301506881321803 0.0 0.0878215685230099 0.0 0.0 0.0 0.025635489100751585 1.6246020004398003e-12 11.789253016336543 0.0005889146694210146 MAILQIMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MAILQIMK 8 0 Q13263;Q13263-2;M0R3C0 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 13628600.0 5970200.0 3966000.0 3692400.0 False True 5780679.268922258 5549644.48241678 2725249.670374395 1.0 0.9600332805614119 0.4714410787371856 22.46280759843876 -6.923127392139864 0.801189334118287 1.0096143247245892 0.38669002588633256 0.9950064831203478 0.016980712978564308 0.09636647853750345 0.09633362818226633 0.014878362336350195 0.04599227879083022 1.193637921812668e-07 6.923127392139864 -0.6229242988382566 down MAILQIMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MAILQIMK 8 0 Q13263;Q13263-2;M0R3C0 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 16423900.0 3861800.0 7432700.0 5129400.0 False True 5858632.935397324 6106276.613049846 4115571.8417041176 1.0 1.042269874283518 0.7024798937032237 22.48213263202458 -6.875730073752318 1.1032926232393634 1.0249753071489167 0.6802831689816297 0.9700769705029308 0.02615557661961121 0.13148172353994608 0.2956898077925954 0.018326128250770627 0.04387614436086231 1.331281589885325e-07 6.875730073752318 -0.34469213816728705 MAILQIMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MAILQIMK 8 0 Q13263;Q13263-2;M0R3C0 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 29201300.0 7268400.0 12599000.0 9333900.0 False True 9955723.90112442 12042334.52067849 7129425.05770465 1.0 1.209589040463286 0.7161131755471281 23.247094790402276 -6.791291515671768 1.491011171809611 1.1169421804378086 0.7106643935940853 0.8055337872508354 0.08917579525804517 0.23342827600739108 1.0251215436493164 0.04707166452805818 0.11011103441653804 1.616994282622477e-07 6.791291515671768 -0.4062777868437233 MAILQIMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MAILQIMK 8 0 Q13263;Q13263-2;M0R3C0 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 18722000.0 3861800.0 8646800.0 6213400.0 False True 4999176.227458584 8165597.978851919 5082624.9548678 1.0 1.633388703923134 1.0166924956457553 22.25325895411703 -10.228540643853483 5.689082472328024 0.9999867277304667 1.3250405997844403 0.2702862401452776 0.25176517276481414 4.2393588665072964e-05 5.748223373545641e-06 0.24378052619275709 0.08125686010609248 5.908256700169016e-11 10.228540643853483 0.3250538720539736 MAIMVQSPMFDGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MAIMVQSPMFDGK 13 0 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 54034800.0 15141700.0 25888400.0 13004700.0 False True 19850915.3324314 22025951.632192798 11659098.393891012 1.0 1.109568564639835 0.5873330372248871 24.242702196270635 -6.851924502179148 1.225797358498959 1.058578401697134 0.5656711092888846 0.9430588968555993 0.053655140094379515 0.15534917358088485 0.44822456064023 0.034234101817527327 0.07932190059912012 1.4062919728989328e-07 6.851924502179148 -0.4929072924082494 MAIMVQSPMFDGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MAIMVQSPMFDGK 13 0 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 46441100.0 18479900.0 8933900.0 19027300.0 False True 17893265.689885832 12501252.859673042 14043479.323235491 1.0 0.6986568621031193 0.7848471914868825 24.09291338109494 -10.120979148807944 7.236896525389131 1.0000001123709308 0.7417520267950011 0.9228992167782517 0.035187054625438655 6.377975903633606e-08 7.786811432628131e-09 0.03406973386416036 0.011356573047201212 7.568692326848057e-11 10.120979148807944 -0.2582480855759297 MAIMVQSPMFDGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MAIMVQSPMFDGK 13 0 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 56735000.0 7975000.0 24503000.0 24257000.0 False True 12098658.05059652 20130248.207187176 19462593.317779217 1.0 1.6638414048072596 1.608657194573709 23.528343700875478 -10.13726362346398 4.804900771090085 0.9999544734768625 1.6362492996945424 0.9943896119657624 0.022528859502416995 1.0988046843012529e-05 1.972922756899333e-06 0.02181502936067719 0.0072711581365063616 7.290148526332555e-11 10.13726362346398 0.6362948262176799 MAIMVQSPMFDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 3 MAIMVQSPMFDGK 13 0 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 72666600.0 17683700.0 22971400.0 32011500.0 False True 24221841.774023682 21956447.591738533 24451042.99753723 1.0 0.9064730831197719 1.0094625844579395 24.52980523268008 -11.159407790939126 10.064134478288556 2.689986431220975 0.9579678337888556 0.18172533164113291 0.042045287857032626 0.04500309254013619 0.0007128140540146826 0.001149126378364661 0.01357005830473203 6.927750032642254e-12 11.159407790939126 -1.7320185974321194 MAIMVQSPMFDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MAIMVQSPMFDGK 13 0 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 35241500.0 16308000.0 8282500.0 10651000.0 False True 13560824.566896051 8237880.528552475 12878074.855340187 1.0 0.6074763734251339 0.9496527878383918 23.692941568526816 -10.185302728993655 7.615940083181724 1.0000001382170078 0.7785645806317629 0.358309530961305 0.13969293622126686 3.278908570906957e-07 3.4932619395991285e-08 0.13525718854167815 0.04508570129731513 6.52675440581001e-11 10.185302728993655 -0.2214355575852449 MAIMVQSPMFDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MAIMVQSPMFDGK 13 0 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 44210000.0 7975000.0 20704000.0 15531000.0 False True 10323794.710752033 19551804.199721307 12704517.361517312 1.0 1.8938582902426837 1.2306053846930725 23.299470022967927 -10.150803897987581 4.668536289776169 0.9999389900580258 1.5622318374739665 0.48930110786781567 0.27077186485670124 0.0001719673791014492 3.12801579164209e-05 0.2622020621660048 0.08739124359800762 7.06636558016995e-11 10.150803897987581 0.5622928474159408 MAIVESDPEEENYK(ub)VPEYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MAIVESDPEEENYKVPEYK 19 1 Q96RL7-4;Q96RL7-2;Q96RL7-3;Q96RL7;H0Y7P8 Q96RL7-4 VPS13A Vacuolar protein sorting-associated protein 13A 1 15863700.0 5804800.0 7636500.0 2422400.0 True False 7610149.013763158 6497163.966843861 2171753.2853015917 1.0 0.853749900966928 0.2853759212038973 22.85949327263412 -6.9455374178781035 0.6058600572893088 1.006328350780218 0.1034079316173283 0.9988029066522703 0.010664921331473474 0.0853287300932353 0.04377086911172243 0.010883563387042872 0.04785810300689722 1.133607164743639e-07 6.9455374178781035 -0.9029204191628898 down MAIVESDPEEENYK(ub)VPEYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MAIVESDPEEENYKVPEYK 19 1 Q96RL7-4;Q96RL7-2;Q96RL7-3;Q96RL7;H0Y7P8 Q96RL7-4 VPS13A Vacuolar protein sorting-associated protein 13A 1 16919000.0 6893900.0 5773400.0 4251700.0 True False 6675056.918030077 8078748.727883272 3138052.221734053 1.0 1.210289114698283 0.47011617432921393 22.670348707998468 -6.830784898166904 1.324279413751256 1.1123090765342185 0.44986123836409514 0.9074511630928661 0.09474037959458691 0.17984954409008774 0.6165543188254541 0.056164554345194885 0.1292562291103543 1.4764376174041233e-07 6.830784898166904 -0.6624478381701233 down MAIVESDPEEENYK(ub)VPEYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MAIVESDPEEENYKVPEYK 19 1 Q96RL7-4;Q96RL7-2;Q96RL7-3;Q96RL7;H0Y7P8 Q96RL7-4 VPS13A Vacuolar protein sorting-associated protein 13A 1 30668600.0 15109000.0 10873000.0 4686600.0 True False 22921457.61585743 8932628.198863255 3760291.455790245 1.0 0.3897059405455751 0.1640511488758383 24.450195454741966 -10.70654885500631 0.2087137070179299 1.8678080737820855 5.12948311362934e-17 0.999333683613154 0.009114901659528878 2.557546625522365 0.11035270901288347 1.2432241029003979 0.12993521870901067 1.9654008746784962e-11 10.70654885500631 -1.8678080737820855 MAIVESDPEEENYK(ub)VPEYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MAIVESDPEEENYKVPEYK 19 1 Q96RL7-4;Q96RL7-2;Q96RL7-3;Q96RL7;H0Y7P8 Q96RL7-4 VPS13A Vacuolar protein sorting-associated protein 13A 1 14849200.0 5804800.0 5625900.0 3418500.0 True False 7950991.428821601 5377329.135636573 2611120.7062174813 1.0 0.6763092607727204 0.3284019017744646 22.92270333415701 -7.222091190829967 0.2884612196024076 1.0809778809323385 3.0884293808285033e-13 0.999925007055131 0.002374853609301231 0.09326927087346218 0.016221595523568888 0.010857968616103967 0.041661712890132534 5.996651485580536e-08 7.222091190829967 -1.0809778809320296 down MAIVESDPEEENYK(ub)VPEYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MAIVESDPEEENYKVPEYK 19 1 Q96RL7-4;Q96RL7-2;Q96RL7-3;Q96RL7;H0Y7P8 Q96RL7-4 VPS13A Vacuolar protein sorting-associated protein 13A 1 17637100.0 6893900.0 7621200.0 3122000.0 True False 5732583.301552898 7580143.082910249 3774795.765502964 1.0 1.3222909610152311 0.6584807523826842 22.450753983432744 -6.774676812692661 1.5564666984637063 1.1837512218045705 0.6540612144534067 0.7481485556430809 0.13601952354723698 0.2589370630250928 1.2385623755990791 0.06885627488043035 0.16321933559888546 1.6800537924193344e-07 6.774676812692661 -0.5296900073511638 MAK(ub)QGQMDAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MAKQGQMDAVR 11 1 M0R1L7;M0R1T5;O43633 M0R1L7 CHMP2A Charged multivesicular body protein 2a 1 12379200.0 4534800.0 5591700.0 2252700.0 True False 4390845.25622402 7824494.970330273 1662650.2904485988 1.0 1.7820019868017567 0.3786629210154453 22.066067260697746 -6.755450780364838 1.6294542719862564 1.4567839591335767 0.37463164470734006 0.6721919595423433 0.3287331263623275 0.2906214600833261 1.5196744511114018 0.15925781103532718 0.3844818143552003 1.7560999059355216e-07 6.755450780364838 -1.0821523144262366 MAK(ub)QGQMDAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MAKQGQMDAVR 11 1 M0R1L7;M0R1T5;O43633 M0R1L7 CHMP2A Charged multivesicular body protein 2a 1 14397810.0 4236000.0 980410.0 9181400.0 True False 6426321.693081738 805448.1755217063 7366692.265649426 1.0 0.12533580078769044 1.1463310766997619 22.61556177132822 -6.679924905668071 1.9021060807517824 0.44653971510107987 1.1424419537920647 0.32371372507189045 0.37071215603032753 0.43874177987753527 3.068950152253112 0.15638759775507474 0.41250873784270725 2.089657424558773e-07 6.679924905668071 0.6959022386909848 MAK(ub)QGQMDAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MAKQGQMDAVR 11 1 M0R1L7;M0R1T5;O43633 M0R1L7 CHMP2A Charged multivesicular body protein 2a 1 13597270.0 5501700.0 5365300.0 2730270.0 True False 7535827.167852094 5128243.305325528 2085436.4576757057 1.0 0.6805149841018991 0.27673623760536814 22.845334446835647 -7.22623704560931 0.35048161063540606 1.0469228521926774 1.4883553343856687e-14 0.9998073592112052 0.004107482582879781 0.0929029899809824 0.0218691106764724 0.009683596535782565 0.04418518952714541 5.939678719532853e-08 7.22623704560931 -1.0469228521926626 down MAK(ub)QGQMDAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MAKQGQMDAVR 11 1 M0R1L7;M0R1T5;O43633 M0R1L7 CHMP2A Charged multivesicular body protein 2a 1 19494170.0 7271400.0 11522000.0 700770.0 True False 6046491.277638457 11459928.699062064 847297.7670056086 1.0 1.8953022790992766 0.14013048693862218 22.527666772077154 -6.7680453803604035 1.5819494067825175 1.5148060111249837 0.13098407112337582 0.7230140190873368 0.37713982611924407 0.2696071657296437 1.3312635258308823 0.18794825750212935 0.4481994252775643 1.705904126114624e-07 6.7680453803604035 -1.3838219400016079 MAK(ub)QGQMDAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MAKQGQMDAVR 11 1 M0R1L7;M0R1T5;O43633 M0R1L7 CHMP2A Charged multivesicular body protein 2a 1 19088500.0 7556300.0 5339200.0 6193000.0 True False 9781779.306941133 5042068.826465997 5065937.545546115 1.0 0.5154551813378323 0.5178953017219817 23.221665484789767 -9.93860776016302 6.818287344892792 1.0000000280131385 0.5166752415299107 0.9999808833420553 0.000996174975366993 4.244475028244835e-10 6.534732612317808e-11 0.0009645423298619197 0.0003215140907903031 1.1518402217698698e-10 9.93860776016302 -0.48332478648322774 MALIGLGVSHPVLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MALIGLGVSHPVLK 14 0 P22695;H3BRG4;H3BSJ9 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 120947080.0 32210580.0 46427700.0 42308800.0 False True 42228382.30770042 39500868.13375718 37931091.230667084 1.0 0.9354104035037623 0.8982369003453463 25.331709645393843 -13.999999943400683 0.062199647529123096 1.4015771079621402 0.7386009877792752 0.9999483549275809 0.00030209322355802254 12.441177214272232 0.06460940628780548 0.7650719554278226 0.14902393675692757 1.0000001303247526e-14 13.999999943400683 -0.662976120182865 MALIGLGVSHPVLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MALIGLGVSHPVLK 14 0 P22695;H3BRG4;H3BSJ9 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 142732800.0 58724100.0 24784800.0 59223900.0 False True 56859935.589447185 34681499.89102456 43711383.91108389 1.0 0.6099461691522072 0.768755424323703 25.760909128952658 -10.123341215872937 5.185437000003157 1.0000088391671897 0.6893507967376002 0.836115250595241 0.06483360693484065 6.625379747220307e-06 1.120126143324397e-06 0.06277665501521977 0.020924956660921513 7.527639008611301e-11 10.123341215872937 -0.3106580424295895 MALIGLGVSHPVLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MALIGLGVSHPVLK 14 0 P22695;H3BRG4;H3BSJ9 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 264258500.0 53871600.0 83826900.0 126560000.0 False True 81727155.74150656 68867334.75244087 101545360.52678137 1.0 0.8426493510952492 1.242492285525725 26.28431219110237 -6.7999421254312225 1.4560587389622728 0.9131760699613023 1.248009674536597 0.832019541762895 0.06740632070073185 0.22083939163946134 0.9243409120691275 0.03641845855463145 0.08470230322445334 1.585104411175269e-07 6.7999421254312225 0.33483360457529465 MALIGLGVSHPVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MALIGLGVSHPVLK 14 0 P22695;H3BRG4;H3BSJ9 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 191598280.0 32210580.0 89792700.0 69595000.0 False True 44119701.88419456 85825361.60924901 53158094.35401659 1.0 1.9452842595021043 1.2048606877160233 25.394919706916735 -10.231421981924568 4.7742532086179414 0.9998768777591037 1.5750724736105806 0.44577148864283966 0.30227665740603127 0.00039622347261074824 6.378621246172652e-05 0.2927402326197461 0.09755937167265967 5.869187961533204e-11 10.231421981924568 0.5751955958514768 MALIGLGVSHPVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MALIGLGVSHPVLK 14 0 P22695;H3BRG4;H3BSJ9 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 108309500.0 52072000.0 22864500.0 33373000.0 False True 43300175.180734016 22741324.400252067 40351140.00068238 1.0 0.5252016719408238 0.9318932275044517 25.367869525927162 -10.145233558047236 7.635274188301307 1.0000000807825906 0.728547449722638 0.37265272131628324 0.16603113230494024 2.285645443581315e-07 2.5412999883062592e-08 0.16075900289732864 0.05358631753074949 7.157583809389294e-11 10.145233558047236 -0.27145263105995265 MALIGLGVSHPVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MALIGLGVSHPVLK 14 0 P22695;H3BRG4;H3BSJ9 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 280765700.0 53871600.0 137517800.0 89376300.0 False True 69737848.16799356 129864813.54213834 73110730.47828095 1.0 1.8621855556727698 1.0483651618008394 26.05543851319482 -10.223704919608888 4.028577444984182 0.9996835306635793 1.4552753586489062 0.2944242278901944 0.33224078501448706 78650501.298906 94257468.50248726 265444.4461342308 0.12158767563562381 5.974410786836266e-11 10.223704919608888 0.45559182798532694 MALK(ub)NLEMISDEIHER ddPTM_RPMI8226_Bortezomib_1h_R1 1 MALKNLEMISDEIHER 16 1 O60239;O60239-2;C9JK30 O60239 SH3BP5 SH3 domain-binding protein 5 1 11511700.0 1589700.0 5446300.0 4475700.0 True False 2084112.0946767 4633733.2695111185 4012597.497945976 1.0 2.223360864968221 1.9253271012605655 20.99100144487009 -10.598198109409738 6.309837078371075 0.9968678764244225 2.0743439831143933 0.9454322674672898 0.12167177453416128 0.005365511675918344 0.00034166823508124136 0.11790654617181591 0.03926939637285922 2.5223299144785005e-11 10.598198109409738 1.0774761066899707 MALK(ub)NLEMISDEIHER ddPTM_RPMI8226_Bortezomib_2h_R1 1 MALKNLEMISDEIHER 16 1 O60239;O60239-2;C9JK30 O60239 SH3BP5 SH3 domain-binding protein 5 1 47712000.0 12614000.0 16945000.0 18153000.0 True False 12213575.474554518 23711226.86700765 13398184.721673273 1.0 1.941382923977264 1.0969911922668953 23.541982269475135 -10.306030785576036 5.537609410070428 0.9999254678571876 1.519187058122 0.33514125634532566 0.3447214809526149 0.00031728397261967487 3.9761967580631666e-05 0.3338227556837892 0.11125837956744764 4.942756483194689e-11 10.306030785576036 0.5192615902648123 MALK(ub)NLEMISDEIHER ddPTM_RPMI8226_Bortezomib_8h_R1 1 MALKNLEMISDEIHER 16 1 O60239;O60239-2;C9JK30 O60239 SH3BP5 SH3 domain-binding protein 5 1 102551000.0 13266000.0 70550000.0 18735000.0 True False 20125491.8745095 57959801.290334046 15032019.038157802 1.0 2.8799197381975365 0.7469143677028348 24.262520707873264 -6.67401606382748 1.9233342109244818 2.1957774308582687 0.7554008687277085 0.29691899156457136 0.7978169771905242 0.45193241678713464 3.2268321832183604 0.33351053431260247 0.8863524321732646 2.1182827820575099e-07 6.67401606382748 -1.4403765621305602 MALK(ub)NLEMISDEIHER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MALKNLEMISDEIHER 16 1 O60239;O60239-2;C9JK30 O60239 SH3BP5 SH3 domain-binding protein 5 1 21723100.0 1589700.0 10957000.0 9176400.0 True False 2177455.0500271698 10472883.51004636 7009123.313890332 1.0 4.809689876223016 3.218952011800599 21.05421150639298 -9.468020370186709 10.38453872271635 1.0000000000001674 4.014320943744478 0.8272176715997583 0.6494160137265886 0.0 0.0 0.6287943514808709 0.20959811716029025 3.403922235396696e-10 9.468020370186709 3.0143209437443104 MALK(ub)NLEMISDEIHER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MALKNLEMISDEIHER 16 1 O60239;O60239-2;C9JK30 O60239 SH3BP5 SH3 domain-binding protein 5 1 49300800.0 12614000.0 28129000.0 8557800.0 True False 10489099.894948905 27977463.493830685 10347196.413203476 1.0 2.66728925971078 0.9864713385164953 23.32238754490941 -6.648027215064773 2.0156204469821875 2.0835840836321813 0.9935326345322716 0.18610821430553526 0.7119624164262518 0.5133554862877656 3.9953936026716264 0.2866935866565717 0.7885035452906909 2.2489136732392102e-07 6.648027215064773 -1.0900514490999096 MALK(ub)NLEMISDEIHER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MALKNLEMISDEIHER 16 1 O60239;O60239-2;C9JK30 O60239 SH3BP5 SH3 domain-binding protein 5 1 94933800.0 13266000.0 72861000.0 8806800.0 True False 17173098.511954393 68806221.3000336 7204052.765398929 1.0 4.006628230318296 0.41949638618704155 24.033647029965714 -6.684369053767066 1.8861537823743508 2.8948294813785194 0.43259061754575434 0.34424987905613136 1.2730850847072779 0.4289324432665323 2.9538630894632 0.5408329956936131 1.4185860671116688 2.0683829360674724e-07 6.684369053767066 -2.462238863832765 MALLATVLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MALLATVLGR 10 0 F8VPD4;P27708;H7C2E4 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 4684400.0 2291800.0 2392600.0 0.0 False True 3004571.9938227693 2035633.4062817553 0.0 1.0 0.6775119419560932 0.0 21.518728060637354 -7.474769268373074 0.7260545399202101 0.9923312574952327 3.1909546418608805e-17 0.9871421772161519 0.047254684024417896 0.11785604742602586 0.1414161097754082 0.04150721282090013 0.0749955209601928 3.351434466115681e-08 7.474769268373074 -0.9923312574952327 down MALLATVLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MALLATVLGR 10 0 F8VPD4;P27708;H7C2E4 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 10205400.0 2291800.0 2532500.0 5381100.0 False True 3139140.393566247 2420605.7761424137 4110195.0072332625 1.0 0.7711046569001854 1.3093377459820588 21.581938122160246 -6.791172449153001 1.491862251905715 0.8722673116656605 1.315231852639645 0.805052036672913 0.09737891960194778 0.23359878969309472 1.0271044518093282 0.05137694532141938 0.12017281539963158 1.6174376598298927e-07 6.791172449153001 0.4429645409739844 MALNHPYFNDLDNQIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 MALNHPYFNDLDNQIKK 17 1 P06493;A0A024QZP7;P06493-2 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 21296900.0 6292800.0 5842200.0 9161900.0 True False 6093038.508504574 8175020.926670523 6762123.538891552 1.0 1.3416985491327436 1.109811390401206 22.53873042765954 -10.265506993551746 4.480152434237931 0.999884389657228 1.225754969768898 0.5582544302612704 0.09466753613920352 0.00010937388102104724 1.7931240449485014e-05 0.09170825649412705 0.03055381590688568 5.426165133703776e-11 10.265506993551746 0.22587058011167005 MALNHPYFNDLDNQIK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 MALNHPYFNDLDNQIKK 17 1 P06493;A0A024QZP7;P06493-2 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 53859400.0 10108000.0 8439400.0 35312000.0 True False 15334574.993784266 6933323.1326668365 28332567.72220058 1.0 0.45213663472754856 1.8476265389608082 23.870284846280658 -6.800220210132782 1.4551168146702105 0.6978065030734945 1.8669733821654204 0.8327839425071991 0.2347494370817467 0.22044000799606664 0.9214771398599171 0.12691696645630052 0.2951089276098754 1.5840897720015928e-07 6.800220210132782 1.169166879091926 MALNHPYFNDLDNQIK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MALNHPYFNDLDNQIKK 17 1 P06493;A0A024QZP7;P06493-2 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 69603000.0 10108000.0 11783000.0 47712000.0 True False 13085005.258467892 11127265.691910565 39028905.56646156 1.0 0.850382974413374 2.9827198992682264 23.641411168373107 -6.890065535964507 1.021995145925711 0.8856027518937434 3.166355332708564 0.9809395839493762 0.13417303166639433 0.11909118719748353 0.22153958608763433 0.10002347234377823 0.24941905773684392 1.2880551667523816e-07 6.890065535964507 2.280752580814821 up MALSFVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MALSFVQR 8 0 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07;J3KSA5;J3KRJ4;J3QLT0;J3KTB0;J3QS88;J3QS84;J3KRE8;J3QLE8;J3QL53 Q13098-7 GPS1 COP9 signalosome complex subunit 1 0 9639200.0 1841500.0 3620900.0 4176800.0 False True 2414224.3331113677 3080675.8341576527 3744624.802694718 1.0 1.2760520188227022 1.5510674593643818 21.203128308892698 -6.971172007611761 0.22847302911883835 0.8859940365343791 1.9489690254984253 0.999990134766849 0.0007065917743820628 0.0759242723605384 0.007655752991647227 0.007146618002055453 0.0273961223164193 1.0686315508728284e-07 6.971172007611761 1.0629749889640463 MALSFVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MALSFVQR 8 0 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07;J3KSA5;J3KRJ4;J3QLT0;J3KTB0;J3QS88;J3QS84;J3KRE8;J3QLE8;J3QL53 Q13098-7 GPS1 COP9 signalosome complex subunit 1 0 6473300.0 1841500.0 2481600.0 2150200.0 False True 2522352.314666309 2371954.706446207 1642367.0447590533 1.0 0.9403740677519118 0.651125156152632 21.26633837041559 -6.940482442369945 0.65506323468782 1.0032217433693653 0.5720051978967302 0.9982263624167452 0.006416754232511227 0.0875473420560165 0.05361325081634584 0.006269278904202219 0.024842651885235774 1.1468788864328843e-07 6.940482442369945 -0.4312165454726351 MALSFVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MALSFVQR 8 0 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07;J3KSA5;J3KRJ4;J3QLT0;J3KTB0;J3QS88;J3QS84;J3KRE8;J3QLE8;J3QL53 Q13098-7 GPS1 COP9 signalosome complex subunit 1 0 4151900.0 1687200.0 1218400.0 1246300.0 False True 1402981.5556332471 1211836.2373665343 1506895.5677598773 1.0 0.8637577824888526 1.0740665561207094 20.420064611944596 -6.731860639590534 1.7167667891240306 0.918179138887286 1.0739771065822332 0.5677435392354373 0.057264904456517364 0.33275409051971316 1.9222187129864274 0.02642629886819317 0.06542934896062824 1.854126497136374e-07 6.731860639590534 0.15579796769494725 MANFQNFK(ub)PR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MANFQNFKPR 10 1 E9PL41;Q9NWT6 E9PL41 HIF1AN Hypoxia-inducible factor 1-alpha inhibitor 1 7222300.0 2587500.0 3164200.0 1470600.0 True False 2505361.2288258914 4427681.561085008 1085405.7429456692 1.0 1.7672827016485722 0.43323323218118615 21.25658719887804 -6.750719774457495 1.647053531437736 1.4507733607183841 0.4304122929341732 0.6521279740468224 0.322429816791968 0.29878399553394663 1.5949274689083408 0.15462524592206184 0.3751238014932064 1.7753346339230113e-07 6.750719774457495 -1.020361067784211 MAQEVLTHLK(ub)EHPDAWTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MAQEVLTHLKEHPDAWTR 18 1 O14980;C9JKM9;C9J673;C9IZS4;C9JQ02;C9JV99;H7BZC5;C9IYM2;F8WF71 O14980 XPO1 Exportin-1 1 8503800.0 2344000.0 3692400.0 2467400.0 True False 3073006.699328287 3141508.312862468 2212097.1169720674 1.0 1.0222913973956367 0.7198478016515872 21.551219481415206 -6.889161504195396 1.0273621479253654 1.0165788973695575 0.6942612626532504 0.9803549956512447 0.01928895757610117 0.11982481295675428 0.2258585932207657 0.01432159978121404 0.035596826656155184 1.2907391879384338e-07 6.889161504195396 -0.32231763471630714 MAQEVLTHLK(ub)EHPDAWTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MAQEVLTHLKEHPDAWTR 18 1 O14980;C9JKM9;C9J673;C9IZS4;C9JQ02;C9JV99;H7BZC5;C9IYM2;F8WF71 O14980 XPO1 Exportin-1 1 10872100.0 2018700.0 2245000.0 6608400.0 True False 1954617.4734805126 3141440.207520336 4877461.792249529 1.0 1.607189258329147 2.495353622089758 20.898454863245213 -6.965671779491858 0.34632891175300096 0.9104618640292919 3.221882831400409 0.9999263314061286 0.005270475763860298 0.07773372374380265 0.014060241766320973 0.012310046379803229 0.07652974235452606 1.08225156003323e-07 6.965671779491858 2.311420967371117 MAQEVLTHLK(ub)EHPDAWTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MAQEVLTHLKEHPDAWTR 18 1 O14980;C9JKM9;C9J673;C9IZS4;C9JQ02;C9JV99;H7BZC5;C9IYM2;F8WF71 O14980 XPO1 Exportin-1 1 47620200.0 4952200.0 15233000.0 27435000.0 True False 7512849.454315244 12514552.13402776 22012460.224812306 1.0 1.6657530821198112 2.9299748861823325 22.840928762539974 -6.96104617553277 0.42042960033479015 0.9443768834437397 3.699074361999654 0.9998070539138699 0.011118464161178107 0.07932949872295186 0.019765953840737784 0.016358301367359187 0.10522434144766986 1.0938400596303183e-07 6.96104617553277 2.754697478555914 MAQEVLTHLK(ub)EHPDAWTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MAQEVLTHLKEHPDAWTR 18 1 O14980;C9JKM9;C9J673;C9IZS4;C9JQ02;C9JV99;H7BZC5;C9IYM2;F8WF71 O14980 XPO1 Exportin-1 1 9267400.0 2344000.0 3085100.0 3838300.0 True False 3210640.144218204 2948790.080938582 2931772.592269872 1.0 0.9184430358066855 0.9131426944715297 21.614429542938097 -13.999999999999982 0.3885431534195003 2.2775676291843805 0.912745064807087 0.9998209050098068 0.0005319895146200451 25.148102747143803 0.20413237203196294 26.967005472732065 0.0014006737247496957 1.0000000000000409e-14 13.999999999999982 -1.3648225643772935 MAQEVLTHLK(ub)EHPDAWTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MAQEVLTHLKEHPDAWTR 18 1 O14980;C9JKM9;C9J673;C9IZS4;C9JQ02;C9JV99;H7BZC5;C9IYM2;F8WF71 O14980 XPO1 Exportin-1 1 13818400.0 2018700.0 6927700.0 4872000.0 True False 1678638.493573279 6890379.105059223 5890712.67441717 1.0 4.104742701563952 3.5092205361487605 20.67886013867949 -10.507455955595672 8.517683687390585 0.9998209789230974 3.806981618856355 0.9673442951449758 0.24312090596408967 0.00082655780786205 4.7797115731746896e-05 0.23541290029274628 0.07846693499281486 3.10845113339993e-11 10.507455955595672 2.8071606399332576 MAQEVLTHLK(ub)EHPDAWTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MAQEVLTHLKEHPDAWTR 18 1 O14980;C9JKM9;C9J673;C9IZS4;C9JQ02;C9JV99;H7BZC5;C9IYM2;F8WF71 O14980 XPO1 Exportin-1 1 47678400.0 4952200.0 9280200.0 33446000.0 True False 6410720.522455949 8763748.71204857 27359171.184940305 1.0 1.3670458229071534 4.267721715383561 22.612055084632424 -6.930324177004844 0.7441272811021725 0.9564162351752111 4.868159769675143 0.9966015713762204 0.08520588935676263 0.09246980002603353 0.07685828958815807 0.07777692311990944 0.2619947066078009 1.1740208856044901e-07 6.930324177004844 3.9117435344999314 up MAQFDAK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MAQFDAKK 8 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 6374000.0 2313200.0 1967900.0 2092900.0 True False 3168452.551879506 1880951.6710249376 1598600.1246285136 1.0 0.5936499411705468 0.5045365516615467 21.59534698041198 -13.999999999999998 0.21322444165185062 3.3817739704246526 0.45366064349872903 0.9994920656525073 0.004860194142392759 12.824118705705445 0.14633585167606056 12.816329088115017 0.05161875010309381 1.0000000000000041e-14 13.999999999999998 -2.9281133269259234 MASTFIGNSTAIQELFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MASTFIGNSTAIQELFK 17 0 Q9BUF5 Q9BUF5 TUBB6 Tubulin beta-6 chain 0 434322700.0 169280000.0 9282700.0 255760000.0 False True 256810136.0257026 7626129.658933863 205208923.89640996 1.0 0.029695594484520693 0.7990686312937112 27.93612690433727 -10.895242292696357 9.353003459155676 1.0613500798703632 0.41438211288920423 0.43582226978997274 0.3140952270063428 0.16174466843949473 0.001811608093240553 0.12241860827720394 0.1013737986099003 1.2727927923731339e-11 10.895242292696357 -0.646967966981159 MATEVAADALGEEWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MATEVAADALGEEWK 15 0 P62753;A2A3R5;A2A3R7 P62753 RPS6 40S ribosomal protein S6 0 18930300.0 3210900.0 8447200.0 7272200.0 False True 4209520.994399827 7186910.686927702 6519742.503868162 1.0 1.7072989293767324 1.548808644152567 22.00522464624516 -10.092295175371882 4.5696397321033375 0.9999588112545833 1.6280537867264366 0.9544161838528872 0.06470338809974267 10138827.979605792 11196075.7262219 3720.94078597952 0.02214969107672972 8.085461707094894e-11 10.092295175371882 0.6280949754718533 MATEVAADALGEEWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MATEVAADALGEEWK 15 0 P62753;A2A3R5;A2A3R7 P62753 RPS6 40S ribosomal protein S6 0 17189300.0 5896600.0 2306200.0 8986500.0 False True 5709415.660635658 3227077.6866741246 6632666.060778763 1.0 0.5652203094834468 1.1617066360238195 22.4449116675144 -6.711236411244606 1.7905518618912124 0.7330520444361983 1.1603729771867055 0.47110479947603034 0.1831780282958098 0.37258566338473925 2.329251308389272 0.08138389133214434 0.20646293124995818 1.9443013994065217e-07 6.711236411244606 0.4273209327505072 MATEVAADALGEEWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MATEVAADALGEEWK 15 0 P62753;A2A3R5;A2A3R7 P62753 RPS6 40S ribosomal protein S6 0 17463600.0 3210900.0 7019400.0 7233300.0 False True 4398056.501309825 6709259.69794829 5524943.514489664 1.0 1.5255055718247696 1.2562238599809326 22.068434707768052 -10.104662195075402 4.575288956838565 0.9999696368539075 1.390864715913031 0.7374755866021707 0.10993379855222855 76558747.50128064 0.422271039427529 25247.882892469002 0.03763326330624075 7.85846647790414e-11 10.104662195075402 0.39089507905912346 MAVHNLYSASAGSLPAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MAVHNLYSASAGSLPAVK 18 0 Q8N228 Q8N228 SCML4 Sex comb on midleg-like protein 4 0 10645500.0 2650900.0 4479000.0 3515600.0 False True 3475355.571352118 3810750.6590052554 3151839.4360164576 1.0 1.0965066971615365 0.9069113566385975 21.72872916004762 -6.7683986194361605 1.5812366698866875 1.0554689138014886 0.9059254822223964 0.7241467679100511 0.040655058848604854 0.26903443148136497 1.3273978504985597 0.020271629785705826 0.048313325470567 1.70451717089106e-07 6.7683986194361605 -0.1495434315790921 MAVLALLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MAVLALLAK 9 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 6191300.0 1134000.0 3264200.0 1793100.0 False True 1486684.9816716204 2777194.083751946 1607567.212629739 1.0 1.8680447559437134 1.0813099159865052 20.503667551935187 -10.236107603078946 4.324520792839287 0.9997688710406247 1.4746773359768408 0.32677012409578166 0.3211831535146825 226584076.7626883 221.08008548943457 532486.8052530348 0.1099495364110392 5.806205421072035e-11 10.236107603078946 0.4749084649362161 MAVLALLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MAVLALLAK 9 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 7626500.0 1134000.0 2268300.0 4224200.0 False True 1553270.4451977152 2168079.0057349782 3226530.960129847 1.0 1.3958155274492487 2.077249953545046 20.56687761345808 -6.962866768543126 0.39294818793094655 0.9594992689153188 2.5381669154781137 0.9998621951483778 0.005222788766948851 0.0786924987251432 0.017460417988560146 0.008785209709592436 0.05725062933574733 1.0892642030323543e-07 6.962866768543126 1.578667646562795 up MAVLNEQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MAVLNEQVK 9 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 0 10985300.0 4128500.0 1008300.0 5848500.0 False True 3997443.027326648 1410919.4482150376 4316602.398760875 1.0 0.35295548643719177 1.0798408805960318 21.930646041484056 -6.671883671182069 1.9304764417716362 0.5876702503634824 1.0769424137467583 0.28750780900088846 0.27473069249483717 0.4568095792437559 3.283799351019199 0.11449040211727596 0.3051646870156649 2.128709159278531e-07 6.671883671182069 0.48927216338327584 MAVLNEQVK(ub)EAEGSSAEYK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MAVLNEQVKEAEGSSAEYK 19 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 74238600.0 23250200.0 28379200.0 22609200.0 True False 30481237.355257105 24145133.981255192 20269816.866760507 1.0 0.7921310312913159 0.664993242581229 24.861418132989623 -12.144114592528407 0.05727455525802293 2.1626917314179184 5.378014277353006e-10 0.9999769846505654 0.0006624201616832478 6.193119929249784 0.04520485611650511 1.3967127069242353 0.5044620979215129 7.17604919738033e-13 12.144114592528407 -2.162691730880117 MAVLNEQVK(ub)EAEGSSAEYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MAVLNEQVKEAEGSSAEYK 19 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 7364500.0 3219800.0 4144700.0 0.0 True False 3117589.2114294134 5799700.324324962 0.0 1.0 1.8603157539366135 0.0 21.571999413435353 -6.789470414398633 1.554278328324408 1.4860878162636857 5.735289913996726e-19 0.7704026986308193 0.36425215845299014 0.2434923996940556 1.1708847086707266 0.18608738395887797 0.42576690142919177 1.6237889646824873e-07 6.789470414398633 -1.4860878162636857 MAVLNEQVK(ub)EAEGSSAEYK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MAVLNEQVKEAEGSSAEYK 19 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 69770300.0 23250200.0 27051800.0 19468300.0 True False 31846427.25302995 25856562.027660176 14870288.50222433 1.0 0.8119140593769468 0.4669374176285201 24.924628194512515 -6.961701949392047 0.4107448421708234 1.0168563910373396 0.24917712596223304 0.9998282036020514 0.0028932767017473934 0.07909866849429618 0.018925611392185668 0.004443147177028117 0.028796055647156944 1.0921896347268002e-07 6.961701949392047 -0.7676792650751065 down MAVLNEQVK(ub)EAEGSSAEYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MAVLNEQVKEAEGSSAEYK 19 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 10540900.0 3219800.0 4933900.0 2387200.0 True False 2677406.361325232 4907320.101397527 2886352.482834298 1.0 1.8328633905869105 1.0780404964025128 21.35240468886963 -10.328145286001417 6.077011050011911 0.999962366549558 1.455451943494712 0.3267978658113272 0.3081551561537671 0.00015713428731848548 1.7372240055671612e-05 0.298394518745421 0.09945664898595692 4.697369396309121e-11 10.328145286001417 0.455489576945154 MAVLNEQVK(ub)EAEGSSAEYKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MAVLNEQVKEAEGSSAEYKK 20 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 26206500.0 10400000.0 12359400.0 3447100.0 True False 8648060.798118638 12292817.459051194 4167872.6724103927 1.0 1.4214536352155922 0.48194303552041423 23.043945234954084 -6.78475367341112 1.5172812350326268 1.2371640022493238 0.4733511167756596 0.7838757744337247 0.17862478010748783 0.24325507239060556 1.1063319654010015 0.09269653318443304 0.21787859012640162 1.6415205598600714e-07 6.78475367341112 -0.7638128854736641 down MAVLNEQVK(ub)EAEGSSAEYKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MAVLNEQVKEAEGSSAEYKK 20 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 1 91517000.0 28642000.0 51660000.0 11215000.0 True False 37077633.61822688 48785075.58721035 9173985.075617578 1.0 1.3157548318625234 0.24742639107118658 25.144045834922814 -6.827534820018196 1.3388621595214665 1.169027323584006 0.22009339778000403 0.9008614728752724 0.14109979124307584 0.18387075966700003 0.6454655509103916 0.08276629688355851 0.19050104991800873 1.4875281051633824e-07 6.827534820018196 -0.948933925804002 down MAVSWHHDENLVDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MAVSWHHDENLVDR 14 0 A0A1B0GTY1;A0A1B0GUC3;A0A1B0GV98;A0A1B0GTC5;A0A1B0GU26;A0A1B0GTC3;A0A1B0GVH5;Q9C0B1;A0A1B0GTI3 A0A1B0GTY1 FTO Alpha-ketoglutarate-dependent dioxygenase FTO 0 3740740.0 970740.0 1230800.0 1539200.0 False True 1329648.811262108 1176419.1862886806 1175672.660819058 1.0 0.8847593261652442 0.8841978805690089 20.342613818693998 MAVTFIGNSTAIQELFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MAVTFIGNSTAIQELFK 17 0 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 0 16977400.0 5469100.0 8433500.0 3074800.0 False True 7170043.062839746 7175254.673525526 2756649.191564288 1.0 1.000726859049535 0.38446759209176884 22.77355035301548 -6.9066296538901835 0.9183778331620253 1.0211734642915706 0.3103104758198303 0.9895863966460897 0.029627959787613053 0.10668925653064532 0.15116779995562254 0.023859626829188324 0.06442256149089383 1.2398534251180487e-07 6.9066296538901835 -0.7108629884717403 down MAVTFIGNSTAIQELFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MAVTFIGNSTAIQELFK 17 0 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 0 57422000.0 21983000.0 15243000.0 20196000.0 False True 21285161.697885815 21329609.391194895 14906061.732987018 1.0 1.0020882008762704 0.7003029596184646 24.343344714155066 -6.905339687958966 0.9268749235300617 1.0107760136622501 0.6649516046619715 0.9890411937213178 0.014841439639461685 0.1075814126686544 0.15607549457425907 0.011877581921427875 0.03182007224002045 1.243541582268967e-07 6.905339687958966 -0.34582440900027867 MAVTFIGNSTAIQELFK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MAVTFIGNSTAIQELFK 17 0 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 0 3839706000.0 1129570000.0 1252211000.0 1457925000.0 False True 1713640272.6285045 1028744163.4808015 1169765484.7187724 1.0 0.6003267896492884 0.6826202111394721 30.674417144671835 -10.135792259892119 7.3898504175967705 1.0000001472838813 0.6414735003943862 0.9619881745682644 0.03359614863978967 8.153841969794895e-08 9.511038957443408e-09 0.03252934461674489 0.010843110348217859 7.314888996817347e-11 10.135792259892119 -0.3585266468894951 MAVTFIGNSTAIQELFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MAVTFIGNSTAIQELFK 17 0 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 0 26273300.0 5469100.0 4847200.0 15957000.0 False True 7491174.0668702265 4633034.676453112 12188285.244730826 1.0 0.6184657618547061 1.6270193611751207 22.83676041453837 -6.804204195700657 1.4386689194359106 0.7905998728354394 1.642433107135866 0.8441757391238969 0.16412978655821245 0.21481073414877974 0.8772719670192133 0.08973179769351036 0.20817367825465324 1.5696246278787737e-07 6.804204195700657 0.8518332343004266 MAVTFIGNSTAIQELFK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MAVTFIGNSTAIQELFK 17 0 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 0 893360000.0 441313000.0 124575000.0 327472000.0 False True 366971312.9807823 123903889.74879847 395944881.1405467 1.0 0.33763917059992954 1.0789532236850397 28.451092047677015 -6.6711269217756195 1.9336907417042393 0.5776261554151444 1.075954378777008 0.28397910210388555 0.28128360907445904 0.4584933301166218 3.3063285707508037 0.11707128636942356 0.31229064511039545 2.1324216257164295e-07 6.6711269217756195 0.49832822336186366 MAVTFIGNSTAIQELFK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MAVTFIGNSTAIQELFK 17 0 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 0 2704369900.0 1129570000.0 900927200.0 673872700.0 False True 1462250632.1535025 850789809.3413436 551234783.1178004 1.0 0.5818358293942802 0.37697694977637286 30.445543466764285 -11.807945943664457 0.11861831941841641 2.2462763811869135 1.6937218158081122e-16 0.9997793430425814 0.003851321625440915 5.048723621808485 0.08167908963940756 1.8741382822515118 0.2775634093239863 1.5561593136308477e-12 11.807945943664457 -2.2462763811869135 MAVTFIGNSTAIQELFK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 MAVTFIGNSTAIQELFKR 18 1 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 1 15224200.0 5214200.0 4146800.0 5863200.0 True False 5048678.075108784 5802638.86527632 4327452.0277703265 1.0 1.1493382582432312 0.8571455663029341 22.26747425735865 -6.767777616177724 1.5829224403479882 1.085901287719792 0.8556377419675747 0.7219664110169846 0.06290396117283117 0.27005749293654313 1.335077020969667 0.031329353332653506 0.07473110824401764 1.7069562252912485e-07 6.767777616177724 -0.2302635457522173 MAVTFIGNSTAIQELFK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 MAVTFIGNSTAIQELFKR 18 1 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 1 69075900.0 7513900.0 17160000.0 44402000.0 True False 11399135.639671125 14097663.928308055 35625925.23791203 1.0 1.2367309569723468 3.1253181262206535 23.44242109775619 -6.930147823496192 0.7455802907971657 0.9714371159949472 3.5144955526628654 0.9965671669173527 0.055720040666239895 0.09256120957734448 0.07730538557154547 0.05080826226991023 0.17074597638092082 1.1744977158510957e-07 6.930147823496192 2.543058436667918 up MAVTFIGNSTAIQELFK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MAVTFIGNSTAIQELFKR 18 1 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 1 15597000.0 5214200.0 5576300.0 4806500.0 True False 4335838.328225988 5546259.365091118 5811516.927254961 1.0 1.279166552171786 1.340344470277504 22.047879532792926 -12.874431208379946 0.2295503090626396 8.775088750591548e-16 1.3715989876804824 0.9994421182089624 0.0034990081777181836 7.92145024672386 0.1453620365743518 3.646054197428565 0.03183236153013552 1.335269077509804e-13 12.874431208379946 1.3715989876804815 MAVTFIGNSTAIQELFK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MAVTFIGNSTAIQELFKR 18 1 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 1 54238900.0 7513900.0 15490000.0 31235000.0 True False 9726891.67111219 14627967.88319566 25550550.498164568 1.0 1.5038686949335658 2.626795009349896 23.213547419848638 -6.95787468417038 0.46442412570304537 0.9686753963892979 3.2075925586225282 0.9996830512093882 0.012105653451798145 0.08046933338690458 0.02400460374662954 0.015368550645420623 0.09272353817717963 1.1018572049692723e-07 6.95787468417038 2.2389171622332302 MAVTFIGNSTAIQELFKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MAVTFIGNSTAIQELFKR 18 1 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 0 101906000.0 18063000.0 22928000.0 60915000.0 False True 27402891.582184933 18836319.26271836 48875123.55000706 1.0 0.6873843662164528 1.7835754085813913 24.707824800140813 -6.830483424602499 1.3256774140974066 0.8330096984561182 1.81337934129859 0.9068456636771135 0.14072715883018172 0.18021992918661164 0.6192449374377279 0.08334253058323557 0.1917993492766782 1.4774628697502938e-07 6.830483424602499 0.9803696428424717 MAVTFIGNSTAIQELFKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MAVTFIGNSTAIQELFKR 18 1 P07437;Q5JP53;Q5ST81 P07437 TUBB Tubulin beta chain 0 92906000.0 18063000.0 30149000.0 44694000.0 False True 23382909.574960984 28471181.646899022 36560150.599166535 1.0 1.2176064555022994 1.5635415465283276 24.478951122233262 -6.964273994477884 0.37030573982641113 0.9734893722783068 1.8197058002150177 0.9998973816039344 0.002350622968261043 0.07820825343653555 0.01573425525258438 0.004557573955111385 0.029375215116762898 1.0857404186401598e-07 6.964273994477884 0.8462164279367109 MCGTLPYVAPELLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MCGTLPYVAPELLKR 15 1 O14757-3;O14757;E7EPP6;O14757-2;E9PKQ3;E9PPA5 O14757-3 CHEK1 Serine/threonine-protein kinase Chk1 1 3695060.0 2968600.0 726460.0 0.0 True False 2468522.431278367 722546.4157889796 0.0 1.0 0.29270401055857387 0.0 21.235216324124483 -8.795626062681398 0.4872974793320801 1.0834114940583122 6.327993931239055e-23 0.9952316479547962 0.02898722987511145 0.3755962546654886 0.19326310922910125 0.12613057785994056 0.059943574709762915 1.6009358771543768e-09 8.795626062681398 -1.0834114940583122 MCK(ub)QDPSVLHTEEMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MCKQDPSVLHTEEMR 15 1 P50502;Q8NFI4;Q3KNR6;F8WAQ7 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 20698200.0 5603000.0 8123700.0 6971500.0 True False 7345587.25952919 6911675.625934586 6250156.055350085 1.0 0.9409289389310971 0.8508722086504332 22.80844640422315 -6.964986153822506 0.3582921083736106 1.0079131757551867 0.7808100152108512 0.9999128482900871 0.0005724024284231292 0.07796569443641282 0.014876670161663375 0.0012125269418080625 0.0076999135332921865 1.0839614723320179e-07 6.964986153822506 -0.22710316054433544 MCK(ub)QDPSVLHTEEMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MCKQDPSVLHTEEMR 15 1 P50502;Q8NFI4;Q3KNR6;F8WAQ7 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 20235800.0 6978700.0 5580300.0 7676800.0 True False 6757164.988447249 7808542.890880057 5666015.780936561 1.0 1.1555945288046618 0.8385196736536358 22.687986650891872 -6.773274750987631 1.561958060149813 1.088871045911463 0.8365128658670073 0.7429160215552777 0.06563698477589369 0.2611660854839457 1.2579099338801252 0.03311447141767473 0.07859052664887684 1.6854863860848377e-07 6.773274750987631 -0.25235818004445565 MCK(ub)QDPSVLHTEEMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MCKQDPSVLHTEEMR 15 1 P50502;Q8NFI4;Q3KNR6;F8WAQ7 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 46341000.0 10103000.0 24917000.0 11321000.0 True False 15326989.628235316 20470366.67259043 9083399.387829434 1.0 1.3355764679895135 0.5926407995407026 23.869571029512404 -6.783901910407068 1.5206083199407778 1.189048467587782 0.5860127940291605 0.7809756409257556 0.14216623750541482 0.24455706452312934 1.117109138801502 0.07361858815764181 0.17315555982224062 1.644743162356233e-07 6.783901910407068 -0.6030356735586214 MCK(ub)QDPSVLHTEEMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MCKQDPSVLHTEEMR 15 1 P50502;Q8NFI4;Q3KNR6;F8WAQ7 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 16999900.0 5603000.0 5530300.0 5866600.0 True False 7674580.515381667 5285953.059743492 4481029.906419625 1.0 0.6887611706137159 0.583879457312173 22.871656465746042 -13.999999999999998 0.15190820078890765 2.509563970683595 0.47098245701918995 0.9995599949601245 0.003706639620979729 11.965409521780291 0.12284353654827054 5.328857577653408 0.1019520268302097 1.0000000000000041e-14 13.999999999999998 -2.038581513664405 MCK(ub)QDPSVLHTEEMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MCKQDPSVLHTEEMR 15 1 P50502;Q8NFI4;Q3KNR6;F8WAQ7 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 18764400.0 6978700.0 5535300.0 6250400.0 True False 5803098.258829865 5505480.24022898 7557329.741415665 1.0 0.9487139446332765 1.3022922246606112 22.46839192632615 -6.87007089150496 1.1336615287535947 0.9709792951602166 1.3230326962005368 0.9647569210299132 0.029286395445725946 0.13679000384531717 0.3285219504351704 0.020047218992779666 0.04747057760899463 1.3487427043295072e-07 6.87007089150496 0.3520534010403201 MCLFAGFQR ddPTM_RPMI8226_Bortezomib_1h_R1 2 MCLFAGFQR 9 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 432755800.0 114649600.0 194437000.0 123669200.0 False True 150306735.86830586 165427757.50949 110873097.50273266 1.0 1.1006010911875082 0.7376455676602296 27.16333442295098 -6.832761821106133 1.315402363825269 1.053663133917259 0.7273081623336065 0.9112967269942333 0.045568798541829464 0.17743684077061989 0.5994409805967233 0.027190599815446727 0.06257741490911681 1.4697320976725665e-07 6.832761821106133 -0.32635497158365256 MCLFAGFQR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MCLFAGFQR 9 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 200780400.0 113779800.0 43052800.0 43947800.0 False True 110167922.52891366 60244007.55738602 32436552.774260595 1.0 0.546838010325328 0.2944282875602705 26.71512897624604 -9.129744196575153 0.18550948843016357 1.4492047752088841 5.167630936865091e-21 0.9996527875841296 0.005439323611372741 0.5743489142491869 0.0639145003567565 0.2991022478659281 0.14941300200119703 7.417470084353927e-10 9.129744196575153 -1.4492047752088841 MCLFAGFQR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MCLFAGFQR 9 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 873550000.0 255344000.0 252827000.0 365379000.0 False True 387375516.1468988 207708046.5036328 293161680.49869555 1.0 0.5361930164550377 0.7567893898269091 28.529157531187447 -10.04602102350517 5.036154461009773 1.000005546445094 0.6464912031389098 0.7739637187434857 0.09005809231876015 5.608507818654038e-06 1.0622431706395085e-06 0.08719974079670381 0.029066124310787617 8.994540393365791e-11 10.04602102350517 -0.35351434330618425 MCLFAGFQR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MCLFAGFQR 9 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 456710700.0 114649600.0 151116100.0 190945000.0 False True 157038655.40894198 144439291.0278832 145847723.63571665 1.0 0.9197690253508032 0.9287377254722208 27.226544484473873 -10.69874249320518 6.65941560915345 1.0007467312757594 0.924253375411512 0.989594758448775 0.003661456492251773 4.098848218388837e-05 1.8542272350774745e-06 0.003579688099872847 0.001181730001446183 2.001048001957868e-11 10.69874249320518 -0.07649335586424744 MCLFAGFQR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MCLFAGFQR 9 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 209940100.0 113779800.0 23252700.0 72907600.0 False True 94612944.99978645 23127433.089800425 88152242.07334511 1.0 0.2444425875323152 0.9317143872177753 26.495534251680315 -10.874297712327124 10.303653625200353 1.0208747672332368 0.588078487375182 0.3238549342342427 0.28057753730561164 0.11353087388238638 0.0013850491734162652 0.22923696184421352 0.09055601077537698 1.3356795836474647e-11 10.874297712327124 -0.4327962798580548 MCLFAGFQR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MCLFAGFQR 9 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 901556000.0 255344000.0 385610000.0 260602000.0 False True 330547841.5827294 364150464.5215671 213175110.00232664 1.0 1.1016573660803277 0.6449145424202483 28.300283853279897 -6.848301413052037 1.2432590174754419 1.0541791471216566 0.6272452310541855 0.9377979118629485 0.04883285477664458 0.15933473172531595 0.4747869058798724 0.03074815594946661 0.07108021217307611 1.4180729960162163e-07 6.848301413052037 -0.4269339160674711 MCSLAVVNLGTHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MCSLAVVNLGTHK 13 0 P57678;I3L2C7 P57678 GEMIN4 Gem-associated protein 4 0 3740300.0 1485400.0 0.0 2254900.0 False True 2034592.5214256516 0.0 1722339.0611232426 1.0 0.0 0.8465277656266961 20.95630845660086 -9.44279837137004 11.140407710134232 1.00015573223244 0.42326388281553107 0.3822912168065167 0.3455935248433683 0.0 0.0 0.334619486284022 0.11153982876134065 3.6074608668078836e-10 9.44279837137004 -0.5768918494169089 MCTLIDK(ub)FDEHDGPVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MCTLIDKFDEHDGPVR 16 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ITV3;A0A3B3ISK1;A0A3B3ITX2;A0A3B3IS23 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 26806400.0 12841000.0 8175900.0 5789500.0 True False 19480735.80284765 6716846.766401735 4645202.787372008 1.0 0.3447943052243377 0.23845109519389832 24.21554483439727 -13.999999999999998 0.2558881199715389 5.695352429904865 0.1980248628436561 0.9995540621699031 0.007111071675667957 14.239224196035863 0.16006809073052222 34.48709747343593 0.04752097537997461 1.0000000000000041e-14 13.999999999999998 -5.497327567061209 MCTLIDK(ub)FDEHDGPVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MCTLIDKFDEHDGPVR 16 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ITV3;A0A3B3ISK1;A0A3B3ITX2;A0A3B3IS23 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 13930700.0 4912400.0 6928100.0 2090200.0 True False 6728647.032618402 6621993.6338370135 1596537.809020267 1.0 0.9841493545040533 0.23727471530022978 22.681885012412287 -6.911482741388369 0.8855707982351897 1.0220551567810428 0.13762685144424527 0.9914691437433172 0.03286954757437401 0.10344637354983899 0.13350766768398856 0.027109456681598462 0.07562654369439963 1.226075625246327e-07 6.911482741388369 -0.8844283053367975 down MDAFMHEK(ub)NED ddPTM_RPMI8226_Bortezomib_1h_R1 2 MDAFMHEKNED 11 1 P49366;P49366-3;A0A087WZK0;P49366-2;M0R1T4 P49366 DHPS Deoxyhypusine synthase 1 234058200.0 109779000.0 115508000.0 8771200.0 True False 143921332.10134828 98274656.64665756 7863640.363291489 1.0 0.682835929961052 0.054638462891338266 27.100705204102177 -7.424711127875049 0.6428480353211012 0.9977902115319773 2.74496029046803e-24 0.9931494810033886 0.032514809118893186 0.11155975888439228 0.1004561626244793 0.029828775540350773 0.06951577459749954 3.760874766923261e-08 7.424711127875049 -0.9977902115319773 down MDAFMHEK(ub)NED ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDAFMHEKNED 11 1 P49366;P49366-3;A0A087WZK0;P49366-2;M0R1T4 P49366 DHPS Deoxyhypusine synthase 1 160704600.0 105577000.0 51043000.0 4084600.0 True False 102225515.92492798 71424736.0857286 3014720.7246265984 1.0 0.6986977315739962 0.029490882949815958 26.60718010316109 -7.4095805696399655 0.6975144901122491 0.9940732119872385 6.439548749466758e-16 0.9908652595572561 0.03876433555695726 0.11163476945076 0.11637718922402487 0.03444469450589759 0.07087762704303975 3.894210562103711e-08 7.4095805696399655 -0.9940732119872379 down MDAFMHEK(ub)NED ddPTM_RPMI8226_Bortezomib_8h_R1 1 MDAFMHEKNED 11 1 P49366;P49366-3;A0A087WZK0;P49366-2;M0R1T4 P49366 DHPS Deoxyhypusine synthase 1 110540700.0 70576000.0 35237000.0 4727700.0 True False 107068951.79672715 28948682.042062398 3793268.022775474 1.0 0.27037419864744855 0.035428272707638715 26.6739649424281 -9.408358526662118 0.3747271643483542 1.2527494487619064 2.462339336047032e-17 0.9979926357131889 0.01840012791326722 0.8134822321659658 0.15864904334120467 0.34039291181020914 0.06343485064812257 3.905183748682499e-10 9.408358526662118 -1.2527494487619064 MDAFMHEK(ub)NED ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MDAFMHEKNED 11 1 P49366;P49366-3;A0A087WZK0;P49366-2;M0R1T4 P49366 DHPS Deoxyhypusine synthase 1 180570900.0 100182000.0 72514000.0 7874900.0 True False 137221992.71675265 69310091.70826891 6015010.808656443 1.0 0.5050946305038407 0.04383416017775192 27.03193648143073 -7.94147390356838 0.5158504335765383 1.0230236019842143 1.1009276338931121e-15 0.993472974897789 0.03154313353750393 0.10601415397407846 0.12624331944660092 0.04068809424031572 0.07767181954386558 1.1442636356999585e-08 7.94147390356838 -1.0230236019842132 down MDAFMHEK(ub)NED ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MDAFMHEKNED 11 1 P49366;P49366-3;A0A087WZK0;P49366-2;M0R1T4 P49366 DHPS Deoxyhypusine synthase 1 212446400.0 105577000.0 105081000.0 1788400.0 True False 87791953.3541319 104514907.79605448 2162346.1713726735 1.0 1.1904839088665238 0.024630345820536446 26.387585378595368 -6.8967149458983545 1.2203886110745212 1.102126240810154 1.5383373302188907e-20 0.9588571792590502 0.10357810091530718 0.12974465832470614 0.3786056788969369 0.06824268727206118 0.1435901556032406 1.268484176634765e-07 6.8967149458983545 -1.102126240810154 down MDAFMHEK(ub)NED ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MDAFMHEKNED 11 1 P49366;P49366-3;A0A087WZK0;P49366-2;M0R1T4 P49366 DHPS Deoxyhypusine synthase 1 92291200.0 70576000.0 18350000.0 3365200.0 True False 91362023.26094477 17328806.36905362 2752768.1298678806 1.0 0.18967187624074106 0.030130332403054693 26.44509126452055 -10.800204132454091 0.3271765935642775 1.860034747000232 1.2688393190729477e-17 0.9991168660686112 0.012618723721544744 2.642773355836895 0.17132320743631238 1.823402300378704 0.05169800360279219 1.584148416444161e-11 10.800204132454091 -1.860034747000232 MDATANDVPSDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDATANDVPSDR 12 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 14633900.0 3182100.0 1508100.0 9943700.0 False True 3081085.977293479 2110292.194637605 7339146.665394295 1.0 0.6849183080867322 2.3819999569895898 21.55500751047595 -6.858746766786142 1.1920818424369692 0.8295899630443595 2.4622222664765028 0.9520941601613526 0.16132278705005987 0.14810031768608317 0.4006321910580161 0.10560299226822578 0.24616674355066245 1.3843733593561164e-07 6.858746766786142 1.6326323034321433 up MDATANDVPSPYEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDATANDVPSPYEVR 15 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 12796500.0 4525300.0 0.0 8271200.0 False True 4381646.828523984 0.0 6104724.589318788 1.0 0.0 1.3932488920781516 22.063041773581404 -6.714089489695573 1.781046816455814 0.3878091922960208 1.3903323105193295 0.4844024978169762 0.42113340854566234 0.3668665383288742 2.2710420016805046 0.18801048603368806 0.47520657096044383 1.9315702611995186e-07 6.714089489695573 1.0025231182233088 MDCK(ub)GLEAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MDCKGLEAVR 10 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 9269200.0 0.0 2610600.0 6658600.0 True False 0.0 2221108.6560391006 5969631.945801343 0.0 MDCK(ub)GLEAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDCKGLEAVR 10 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 7401900.0 1576600.0 2494900.0 3330400.0 True False 1526551.6959872092 3491126.580731626 2458068.3301416133 1.0 2.2869363611521467 1.610209688019769 20.5418450159154 -10.29034668812462 5.458100777879219 0.9998730269720271 1.9485730245859927 0.7237349905556993 0.27627250741771286 0.0004269228974193743 5.5507727445466815e-05 0.26753482009108925 0.08916656835362949 5.124521409327505e-11 10.29034668812462 0.9486999976139656 MDCK(ub)GLEAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MDCKGLEAVR 10 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 39117300.0 5219000.0 6242300.0 27656000.0 True False 7917604.560007932 5128312.7936874945 22189779.4779446 1.0 0.6477101445039024 2.802587488395906 22.916632583956403 -6.864951319473331 1.1603799154604055 0.805687728829789 2.9172934460503273 0.9593843731587649 0.19020821373643823 0.14179252824610306 0.3600056036109486 0.12756023529464716 0.2996451576895218 1.3647361027252848e-07 6.864951319473331 2.111605717220538 up MDCK(ub)GLEAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MDCKGLEAVR 10 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 9945900.0 0.0 2501400.0 7444500.0 True False 0.0 2390879.876976361 5686262.424290205 0.0 MDCK(ub)GLEAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MDCKGLEAVR 10 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 37662700.0 5219000.0 3823700.0 28620000.0 True False 6756098.381870203 3610907.733697559 23411453.665998697 1.0 0.5344664227192616 3.4652327930603652 22.687758906048852 -6.8662452978810515 1.1536922725676348 0.7418076025652375 3.6251141364807093 0.960794399981346 0.2546273942297927 0.14051024269746074 0.3518868179053606 0.17164003632061292 0.40394218468409265 1.360675929432999e-07 6.8662452978810515 2.883306533915472 up MDELQLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDELQLFR 8 0 P55072;C9IZA5;C9JUP7 P55072 VCP Transitional endoplasmic reticulum ATPase 0 5376180.0 1648200.0 803680.0 2924300.0 False True 1595878.7931790669 1124593.6151358339 2158338.1028804695 1.0 0.7046861077059553 1.3524448799654496 20.60591965251364 -6.7827812118590645 1.5253074604598258 0.83338776821622 1.358005104949637 0.7770108052182877 0.1250379694375457 0.2462824293013934 1.1319614496810277 0.06455794472626109 0.151961935960021 1.648992909173577e-07 6.7827812118590645 0.5246173367334172 MDETDASSAVK(ub)VK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MDETDASSAVKVK 13 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 2539420.0 384120.0 1180000.0 975300.0 True False 503585.0398233718 1003948.5996039737 874385.31173821 1.0 1.9936029075766433 1.7363210631612356 18.941875899484973 -10.068407731811245 4.905553064785537 0.9999773188963997 1.8649619852604642 0.937772413514634 0.105034873175744 2.6745765038360176e-05 5.078979357127541e-06 0.10170230831252407 0.033899859544709206 8.542643211707859e-11 10.068407731811245 0.8649846663640645 MDEVLYSIAEKVK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 MDEVLYSIAEKVK 13 1 P83876;O14835;K7ES07 P83876 TXNL4A Thioredoxin-like protein 4A 1 4642310.0 2086700.0 1811100.0 744510.0 True False 2735683.907631546 1540890.939612507 667475.2470442075 1.0 0.5632562063599494 0.24398843930111902 21.38347011415437 -8.053157107524036 0.2688403898076005 1.1604632432738002 2.764106734907197e-20 0.9994408949879804 0.007327234737359373 0.09491888730945368 0.05247427169462009 0.06947729446284621 0.09543634886981678 8.847954741202536e-09 8.053157107524036 -1.1604632432738002 down MDFILSHAVYCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MDFILSHAVYCR 12 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 7988100.0 2544500.0 3019200.0 2424400.0 False True 3335864.1409730543 2568747.1287494227 2173546.3444869416 1.0 0.770039492075997 0.6515692044499538 21.66962910297016 -13.999999998738714 0.08457890894626713 2.2084084183209463 0.3259169102643071 0.9998671043860329 0.0016675578751338654 12.213922522662582 0.08312769907132771 2.7076427581276454 0.29417259561207637 1.0000000029042187e-14 13.999999998738714 -1.8824915080566391 MDFILSHAVYCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MDFILSHAVYCR 12 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 7015700.0 2544500.0 1683700.0 2787500.0 False True 3485270.412526977 1609308.5667486594 2129149.9103645533 1.0 0.46174568290723783 0.6108994879455636 21.73283916449305 -10.5526004360296 9.62316291930888 1.0000229518157095 0.5363225854264508 0.9279825304661328 0.06089178592307681 2.998587942063562e-05 1.3941197929213331e-06 0.05896112065376985 0.0196527394000753 2.801557651504887e-11 10.5526004360296 -0.4637003663892587 MDIDVPDVEVQGPDWHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDIDVPDVEVQGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 16462400.0 4908200.0 3348400.0 8205800.0 False True 4752391.877612848 4685433.581675324 6056454.811276739 1.0 0.9859106114011882 1.2744013892892456 22.180222373598067 -6.8954169914574 0.9897499394239505 0.9864513563934059 1.3020198751752468 0.984146130496867 0.016721079975305014 0.11485924284756442 0.1970374313289122 0.012771573324068895 0.032528866422771335 1.2722809032818333e-07 6.8954169914574 0.3155685187818409 MDILAQVLQILLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MDILAQVLQILLK 13 0 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21;A0A590UJ56 A0A590UJC4 CUL1 Cullin-1 0 161515000.0 44287000.0 75712000.0 41516000.0 False True 67186616.81338786 62200602.05944402 33310344.402890798 1.0 0.9257885723314125 0.49578838737201086 26.00167054930135 -6.936577562571669 0.6906660977396332 1.005229395391367 0.3906428987344029 0.9976804309527048 0.010704960244384209 0.08936317807826098 0.06198264589544175 0.01016779129505997 0.03760103192873351 1.1572373375029387e-07 6.936577562571669 -0.6145864966569641 down MDILAQVLQILLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MDILAQVLQILLK 13 0 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21;A0A590UJ56 A0A590UJC4 CUL1 Cullin-1 0 86422600.0 44287000.0 4474600.0 37661000.0 False True 57330394.52728216 4225584.576510474 30807084.43449256 1.0 0.07370583459877673 0.5373604121951787 25.772796871393798 -10.117255963493896 6.29103704287879 1.000001942120125 0.30553312520940984 0.7494519233344346 0.1892861886694892 5.15608987751453e-06 7.232357185713585e-07 0.18327607738012877 0.061091854698665266 7.633857284202597e-11 10.117255963493896 -0.6944688169107152 MDK(ub)LLGELHTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDKLLGELHTLR 12 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 55663000.0 17620000.0 21975000.0 16068000.0 True False 17060662.744700354 30749732.098111097 11859308.770332528 1.0 1.8023761771894269 0.6951259132073547 24.024170355411766 -6.712365481541155 1.7870806819813387 1.4921023667143902 0.6975791599403177 0.4761597171196741 0.33799608310016255 0.37035617331388315 2.307145334261536 0.15043848589571984 0.381048203288676 1.9392532076094463e-07 6.712365481541155 -0.7945232067740725 MDK(ub)LLGELHTLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MDKLLGELHTLR 12 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 25800000.0 0.0 12949000.0 12851000.0 True False 0.0 10638149.779001214 10310994.217206603 0.0 MDK(ub)LLGELHTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MDKLLGELHTLR 12 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 42305100.0 17620000.0 20991000.0 3694100.0 True False 14651810.698350992 20877917.316612735 4466519.230411436 1.0 1.4249376917599998 0.30484418085705456 23.804575630846042 -6.803891399592874 1.4399817864932685 1.2332996453953078 0.2878518517022027 0.8433361049693522 0.1827407511828773 0.21522227710102168 0.880604202331479 0.09981909282349082 0.2316133662130501 1.5707555409944725e-07 6.803891399592874 -0.9454477936931052 down MDK(ub)LLGELHTLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MDKLLGELHTLR 12 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 29530000.0 0.0 24720000.0 4810000.0 True False 0.0 23344310.269373603 3934629.3547677724 0.0 MDLFSALIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDLFSALIK 9 0 Q9C0C9;K7ES11 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 0 3912590.0 1668500.0 775090.0 1469000.0 False True 1615534.3807907244 1084587.4790409522 1084224.8309446406 1.0 0.6713490544906262 0.6711245788616185 20.62358002278631 MDLFSALIK(ub)GPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MDLFSALIKGPTR 13 1 Q9C0C9;K7ES11 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 3130580.0 564680.0 1398800.0 1167100.0 True False 740300.9483688978 1190104.4924796948 1046339.6876137232 1.0 1.6075955259841925 1.4133977403637257 19.497752351200415 -10.121522429697551 4.6348520254666585 0.9999616234891846 1.5104966331161427 0.9020926708125384 0.07928091407277074 55303966.00736865 2.2128195587376145 25549.531389611955 0.0271399656231127 7.55923018713411e-11 10.121522429697551 0.5105350096269581 MDLFSALIK(ub)GPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDLFSALIKGPTR 13 1 Q9C0C9;K7ES11 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 5318400.0 1650100.0 1302300.0 2366000.0 True False 1597718.4787190733 1822315.1814047836 1746273.6215214566 1.0 1.1405733899164605 1.0929795485131293 20.607581794150782 -10.144743931051243 4.184653679919586 0.9999692103435828 1.1167764691946207 0.8892199991701178 0.01943010444002891 13584948.925320527 0.2095278373448319 4030.3194375555076 0.006651441552894721 7.165657875890994e-11 10.144743931051243 0.11680725885103793 MDLFSALIK(ub)GPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MDLFSALIKGPTR 13 1 Q9C0C9;K7ES11 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 4124780.0 564680.0 1727700.0 1832400.0 True False 773457.4559032145 1651364.5012601162 1399624.8594626035 1.0 2.1350424495316487 1.8095692901792177 19.560962412723306 -10.701562727706287 6.5152114514271355 0.9889485064819786 1.972305869855433 0.9224752242009876 0.13287386089750242 0.020994308359050275 0.0009616688490352532 0.1266297896092735 0.042884854200192314 1.988095637312489e-11 10.701562727706287 0.9833573633734544 MDLFSALIK(ub)GPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MDLFSALIKGPTR 13 1 Q9C0C9;K7ES11 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 5083000.0 1650100.0 1403400.0 2029500.0 True False 1372131.2618245736 1395839.6056469115 2453859.066652227 1.0 1.0172784809164774 1.7883559211304902 20.38798706958506 -6.911732116800505 0.8838550985096537 0.9774127817398208 1.8917870577745919 0.9915587432583365 0.03377645582481081 0.10328456934555194 0.1326372302381694 0.027892068535861524 0.0779509984033833 1.2253718047721238e-07 6.911732116800505 0.9143742760347711 MDSTEPPYSQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDSTEPPYSQK 11 0 P68104;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 11474600.0 2382100.0 1769900.0 7322600.0 False True 2306481.539395618 2476630.299906568 5404591.386708792 1.0 1.073769834097842 2.343219008865335 21.137262314739242 -6.918837406065292 0.8333146776978398 0.9707996850674269 2.5425462537985686 0.993851635099099 0.048344442191222206 0.0988604875796553 0.10919796751751466 0.041399298060303305 0.12266329667845044 1.2054871738661213e-07 6.918837406065292 1.5717465687311418 up MDSTEPPYSQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 2 MDSTEPPYSQKR 12 1 P68104;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 66361250.0 20113900.0 23579550.0 22667800.0 True False 26369517.683284648 20061573.052366015 20322353.500891417 1.0 0.7607864995226222 0.7706759655211114 24.65236784776528 -9.923284978908944 5.369430346009976 1.000000387585992 0.7657312325230304 0.9986652528878623 0.004037357591988702 1.873163745494377e-08 3.7536371510007605e-09 0.003909161142930483 0.0013030515590534257 1.1932048805732825e-10 9.923284978908944 -0.23426915506296153 MDSTEPPYSQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 2 MDSTEPPYSQKR 12 1 P68104;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 75467450.0 17471700.0 27298750.0 30697000.0 True False 16917070.44702507 38199283.236100614 22656534.809739716 1.0 2.2580318120516014 1.3392705835615852 24.01197642076171 -10.161958660486938 4.7391108231805505 0.999915594685039 1.7986511978106197 0.501869524334232 0.3750827008943752 0.00033795387012096773 5.976256078653727e-05 0.3632107129140282 0.12105742116519222 6.887178507244434e-11 10.161958660486938 0.7987356031255807 MDSTEPPYSQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 2 MDSTEPPYSQKR 12 1 P68104;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 394011340.0 39620700.0 33557540.0 320833100.0 True False 60107498.56116229 27568934.800743267 257420297.15885654 1.0 0.45866049096504224 4.282665280055181 25.84104164619924 -6.871032397290874 1.1285693009522537 0.6918149206630647 4.511105511150926 0.9657052964293349 0.3128893827455715 0.13587143428633247 0.3228012781057644 0.21501912808469553 0.510018646782619 1.3457599599572117e-07 6.871032397290874 3.819290590487861 up MDSTEPPYSQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MDSTEPPYSQKR 12 1 P68104;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 57229110.0 20113900.0 13160830.0 23954380.0 True False 27550552.387709264 12579341.013555113 18296848.79994206 1.0 0.4565912449424047 0.6641191269945126 24.71557790928817 -10.335476862470049 5.3203727925704785 1.0001281116085083 0.5603551859684646 0.8568150562455608 0.08472290307142663 0.00012878376567875485 1.608527097979344e-05 0.0820562983904486 0.027344199386488646 4.6187359807835435e-11 10.335476862470049 -0.4397729256400438 MDSTEPPYSQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MDSTEPPYSQKR 12 1 P68104;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 74585880.0 17471700.0 37420300.0 19693880.0 True False 14528492.677547079 37218709.41655196 23811779.25378712 1.0 2.5617736294193314 1.6389710744451012 23.792381696195985 -10.182349121382366 6.784266365483813 0.9999968783930077 2.1003723519322164 0.6546764382944585 0.3767325655039152 1.7787891145645677e-05 2.143197930955846e-06 0.3647707753448703 0.12158991268088812 6.571293707020301e-11 10.182349121382366 1.1003754735392088 MDSTEPPYSQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MDSTEPPYSQKR 12 1 P68104;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 289134300.0 39620700.0 37318400.0 212195200.0 True False 51289777.190757714 35241598.23448991 173577850.90661496 1.0 0.6871076492186509 3.3842582365105933 25.61216796829169 -6.878003303276379 1.0908390011679971 0.8107359103056122 3.5682594271206036 0.9720404360288236 0.201404486609076 0.12941515769910794 0.2830790672870562 0.1424692983929407 0.34285599850359894 1.3243314621919996e-07 6.878003303276379 2.7575235168149916 up MDTLAHVLYYPQK(ub)PLVTTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MDTLAHVLYYPQKPLVTTR 19 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 14702800.0 2968000.0 5494000.0 6240800.0 True False 3891076.742152888 4674316.615444273 5595061.881980741 1.0 1.201291294208201 1.4379212369080796 21.891738003613764 -6.968990748261586 0.28124797384881856 0.9486463916568553 1.697789093306451 0.999973404696059 0.000922964931983304 0.07663155871904394 0.010197118299442708 0.004339652428509238 0.021685656061514513 1.0740122916900579e-07 6.968990748261586 0.7491427016495957 MDTLAHVLYYPQK(ub)PLVTTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MDTLAHVLYYPQKPLVTTR 19 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 32896900.0 4946100.0 9968800.0 17982000.0 True False 4789088.76285826 13949393.826605247 13271974.751563312 1.0 2.9127448910092584 2.7712943753504855 22.19131974462427 -10.390059180686698 5.63745788332133 0.9993289133883656 2.842019633179879 0.9955968312111539 0.05774693120295111 0.00048721138439611616 5.271322795502103e-05 0.05592930238665302 0.018637741903630912 4.073247684596137e-11 10.390059180686698 1.8426907197915132 MDTLAHVLYYPQK(ub)PLVTTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MDTLAHVLYYPQKPLVTTR 19 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 116173700.0 9785700.0 26008000.0 80380000.0 True False 14845622.330498109 21366669.19856853 64492857.76819444 1.0 1.439257224985032 4.344234032931278 23.82353423677521 -6.93381137995631 0.7148118112760736 0.9614550051411955 5.002951834327116 0.9972357895373953 0.07801343986576645 0.09070645611753735 0.06833462764364476 0.07276028886632688 0.25756390803650814 1.1646317351040748e-07 6.93381137995631 4.04149682918592 up MDTLAHVLYYPQK(ub)PLVTTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MDTLAHVLYYPQKPLVTTR 19 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 18612900.0 2968000.0 5587900.0 10057000.0 True False 4065349.8071841486 5341008.101285758 7681743.730416626 1.0 1.313788075960231 1.8895652513940395 21.954948065136655 -6.961693943222914 0.4108637500405208 0.9719025602694077 2.2528485295028617 0.9998279561712624 0.004831819487874691 0.07910147101201111 0.01893574296581192 0.007416024795710296 0.04805972794053444 1.0922097693034651e-07 6.961693943222914 1.280945969233454 MDTLAHVLYYPQK(ub)PLVTTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MDTLAHVLYYPQKPLVTTR 19 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 24577300.0 4946100.0 6842200.0 12789000.0 True False 4112901.2993821767 6805339.710529633 15463120.770345103 1.0 1.6546323908993157 3.7596624972906376 21.971725020058546 -6.949880805758286 0.5601497720641114 0.9724906146266379 4.542433052692553 0.9991919027614931 0.03346866226448724 0.0835336233285243 0.03616058534683687 0.03587000660088312 0.17499076915174683 1.1223264400090005e-07 6.949880805758286 3.5699424380659153 MDTLAHVLYYPQK(ub)PLVTTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MDTLAHVLYYPQKPLVTTR 19 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 70147700.0 9785700.0 16983000.0 43379000.0 True False 12667781.554985102 16037881.120743172 35484467.10612705 1.0 1.2660370761154978 2.801158746865428 23.59466055886766 -6.936667561798886 0.68987876298346 0.9813782988914064 3.1774596292354067 0.9976938862076538 0.03812149101506327 0.08932052303031153 0.06178485864029938 0.036230592409482454 0.13417925958825178 1.1569975470391613e-07 6.936667561798886 2.1960813303440005 up MEAK(ub)NSYVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MEAKNSYVR 9 1 Q12933-3;Q12933;Q12933-2;Q12933-4 Q12933-3 TRAF2 TNF receptor-associated factor 2 1 8276900.0 2478900.0 2656300.0 3141700.0 True False 3249861.9057017444 2259990.394176302 2816627.021314404 1.0 0.6954112081535665 0.8666912942893825 21.63194698525233 -10.14593247855529 5.094139575065592 1.0000097634426361 0.7810512518436449 0.6854121848577135 0.06992480235649629 7.754039508493843e-06 1.299991105486396e-06 0.06770741751300234 0.022568132917646158 7.146074202217864e-11 10.14593247855529 -0.21895851159899127 MEAK(ub)NSYVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MEAKNSYVR 9 1 Q12933-3;Q12933;Q12933-2;Q12933-4 Q12933-3 TRAF2 TNF receptor-associated factor 2 1 44886500.0 3092300.0 8378200.0 33416000.0 True False 4691245.177411868 6883044.750824626 26811312.95324688 1.0 1.4672106211728546 5.715180498845409 22.16153947135035 -6.927796189543551 0.7646635361350089 0.9298440947953199 6.540266118704677 0.9960870970477842 0.13268957986184926 0.09379859306001447 0.08340502254406566 0.11933783029649776 0.38913055671931174 1.1808746794010127e-07 6.927796189543551 5.610422023909357 up MEAK(ub)NSYVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MEAKNSYVR 9 1 Q12933-3;Q12933;Q12933-2;Q12933-4 Q12933-3 TRAF2 TNF receptor-associated factor 2 1 7694500.0 2478900.0 1916900.0 3298700.0 True False 3395416.319753628 1832205.0196593853 2519614.9988590316 1.0 0.5396113015656149 0.7420636415630633 21.695157046775222 -10.27764778806591 5.654206307593438 1.000029577576563 0.6408374715643337 0.8075584692406352 0.08265082170438645 3.081900864627778e-05 3.937349743543158e-06 0.08003289199139368 0.0266754380009511 5.2765761719017414e-11 10.27764778806591 -0.3591921060122294 MEAK(ub)NSYVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MEAKNSYVR 9 1 Q12933-3;Q12933;Q12933-2;Q12933-4 Q12933-3 TRAF2 TNF receptor-associated factor 2 1 12433400.0 3356300.0 4537200.0 4539900.0 True False 2790912.159300536 4512757.203036317 5489172.099874086 1.0 1.6169470572543254 1.9668021731109564 21.412305287301862 -9.537430098406087 0.13838485481771906 1.3037384273730069e-23 2.596445326040206 0.9998301913876889 0.005208309793077793 1.0039473913761219 0.05598896585667331 0.7081220794662706 0.32241176096251223 2.9011481135775935e-10 9.537430098406087 2.596445326040206 MEEDPDDVPHGHITSLAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MEEDPDDVPHGHITSLAVK 19 0 P41227;P41227-2;F8W808;A8MWP7 P41227 NAA10 N-alpha-acetyltransferase 10 0 18350900.0 1190600.0 7028300.0 10132000.0 False True 1560888.1297868022 5979705.03609882 9083637.833006803 1.0 3.8309632330380863 5.8195316241193495 20.57393571113371 -8.091533572551192 0.27095593450340466 1.858728157471612e-19 7.327697281555304 0.999347886114975 0.050499965623335766 0.09542090437158265 0.056920718045759836 0.47984558214805473 0.6320648545332818 8.099653259793126e-09 8.091533572551192 7.327697281555304 MEEDPDDVPHGHITSLAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MEEDPDDVPHGHITSLAVK 19 0 P41227;P41227-2;F8W808;A8MWP7 P41227 NAA10 N-alpha-acetyltransferase 10 0 12178100.0 1190600.0 5591100.0 5396400.0 False True 1630796.9947552048 5344066.714704779 4121881.46234665 1.0 3.276966251404556 2.527525789907024 20.637145772656602 -10.099148156936375 5.532683125992581 0.9999802694637282 2.9022460206563263 0.8957257172020598 0.30595778721270517 7.446313182693776e-05 1.212386694876786e-05 0.29624541125476084 0.09874745120949917 7.958877917921292e-11 10.099148156936375 1.9022657511925982 MEEDPDDVPHGHITSLAVK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 MEEDPDDVPHGHITSLAVKR 20 1 P41227;P41227-2;F8W808;A8MWP7 P41227 NAA10 N-alpha-acetyltransferase 10 1 22349500.0 4504700.0 9092300.0 8752500.0 True False 5905705.323576851 7735764.2815078115 7846875.259908432 1.0 1.3098798293617817 1.3286940051990084 22.49367794157314 -12.115777935534965 0.4326335763012008 7.501819950385982e-12 1.3291037319229355 0.9998141552680896 0.002054532583279767 6.418242378963337 0.2179790153842708 5.848058850602323 0.004422544177122159 7.659881736496257e-13 12.115777935534965 1.3291037319154337 MEEDPDDVPHGHITSLAVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 2 MEEDPDDVPHGHITSLAVKR 20 1 P41227;P41227-2;F8W808;A8MWP7 P41227 NAA10 N-alpha-acetyltransferase 10 1 32547900.0 4906000.0 7916700.0 19725200.0 True False 4750261.715408626 11077879.595045106 14558578.376684275 1.0 2.3320566862897927 3.064795004759421 22.179575570161592 -8.932508485390716 0.21243803007054768 1.3521094852094172e-21 3.768977258759318 0.9994995489835767 0.01912036266084213 0.42161574909677657 0.06897517001101329 0.6643455938032804 0.3666783541903938 1.1681309063063543e-09 8.932508485390716 3.768977258759318 MEEDPDDVPHGHITSLAVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 MEEDPDDVPHGHITSLAVKR 20 1 P41227;P41227-2;F8W808;A8MWP7 P41227 NAA10 N-alpha-acetyltransferase 10 1 80313000.0 13342000.0 36271000.0 30700000.0 True False 20240789.430853747 29798156.663383514 24632131.543711986 1.0 1.4721835215557915 1.2169550811177534 24.27076222330343 -10.078788036861038 4.324848809626257 0.9999663514439471 1.3445693013804174 0.7084678848023646 0.1041965746374063 15046318.331671732 11688167.528595915 4469.216263812414 0.035669259656485784 8.340881730063397e-11 10.078788036861038 0.34460294993647034 MEEDPDDVPHGHITSLAVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MEEDPDDVPHGHITSLAVKR 20 1 P41227;P41227-2;F8W808;A8MWP7 P41227 NAA10 N-alpha-acetyltransferase 10 1 29211000.0 4504700.0 7624300.0 17082000.0 True False 6170209.3249401655 7287433.21581149 13047583.414833114 1.0 1.1810674212227246 2.1146095258218227 22.55688800309603 -6.939124018346465 0.6676714770767133 0.9893460326867521 2.3599919230329838 0.9980467944851669 0.021584022099716466 0.0881686872839608 0.05644841177408951 0.020873430082190288 0.08066323929777064 1.1504718100851097e-07 6.939124018346465 1.3706458903462315 up MEEDPDDVPHGHITSLAVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MEEDPDDVPHGHITSLAVKR 20 1 P41227;P41227-2;F8W808;A8MWP7 P41227 NAA10 N-alpha-acetyltransferase 10 1 24110200.0 4906000.0 9909300.0 9294900.0 True False 4079556.372650965 9855916.634057943 11238420.615238126 1.0 2.4159285308891074 2.754814393687422 21.95998084559587 -10.19475012204091 0.32690962350207375 2.2107095234279494e-13 2.841756972380472 0.9989480257933017 0.02465154506994374 1.6210634168908589 0.1507052200270329 1.5612467587264975 0.10879865194762336 6.386308264968631e-11 10.19475012204091 2.8417569723802507 MEEDPDDVPHGHITSLAVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MEEDPDDVPHGHITSLAVKR 20 1 P41227;P41227-2;F8W808;A8MWP7 P41227 NAA10 N-alpha-acetyltransferase 10 1 111053900.0 18050600.0 40138300.0 52865000.0 True False 23366857.530520435 37904568.320598625 43244112.4407065 1.0 1.6221508720669808 1.8506601661872395 24.47796039191504 -10.923236230084324 0.1971030615443047 1.1191638916532473e-18 2.0378502365864763 0.999394593719804 0.008844541797988322 2.9482871191239655 0.10849886249483805 1.497564648390993 0.14516431505868982 1.1933388233300922e-11 10.923236230084324 2.0378502365864763 MEEEAGQTSIEPSK(ub)SSIIPFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MEEEAGQTSIEPSKSSIIPFR 21 1 Q7Z7L7 Q7Z7L7 ZER1 Protein zer-1 homolog 1 35746100.0 2776500.0 9209600.0 23760000.0 True False 3594233.9829972414 8697077.664110966 19435923.79818757 1.0 2.4197305198417967 5.407528805895908 21.777252900020063 -6.9590366712377545 0.44880366977355285 0.9024628944841723 7.043005812330404 0.9997327868796521 0.03002769800526044 0.08004704693640345 0.02241641947506628 0.03986457145345696 0.24718483167389643 1.0989130447859403e-07 6.9590366712377545 6.140542917846232 MEEESGAPGVPSGNGAPGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEEESGAPGVPSGNGAPGPK 20 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 9410900.0 2461900.0 1156900.0 5792100.0 False True 2383748.332075927 1618856.2031538007 4274975.250724608 1.0 0.6791221125864377 1.7933836358478643 21.18480049839954 -6.829688576183268 1.329231756699873 0.8285035396332067 1.8231915608107483 0.9052609371247632 0.14415069691620272 0.1811976314541242 0.6262303006609957 0.0851490817134004 0.19596152408802917 1.4801694073438587e-07 6.829688576183268 0.9946880211775416 MEEESGAPGVPSGNGAPGPK(ub)GEGERPAQNEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MEEESGAPGVPSGNGAPGPKGEGERPAQNEK 31 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 47869400.0 7728400.0 16353000.0 23788000.0 True False 11724547.821721654 13434679.383427812 19086291.37334923 1.0 1.1458590631988261 1.6278914687002883 23.483028947895537 -6.9492574325224865 0.5669356556264334 0.9939098275079022 1.8031538280779673 0.9991417260897225 0.007860282122409757 0.08378526597018102 0.03720676474959969 0.008356891584533226 0.040133125096090856 1.1239385503320976e-07 6.9492574325224865 0.8092440005700651 MEEESGAPGVPSGNGAPGPK(ub)GEGERPAQNEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MEEESGAPGVPSGNGAPGPKGEGERPAQNEK 31 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 9035000.0 2561500.0 2702400.0 3771100.0 True False 3508555.7719346974 2582999.0323582436 2880443.8482424296 1.0 0.7362000778268716 0.8209770730405369 21.742445864970414 -10.458266770940108 8.565312543341738 1.0000050709065154 0.7785885754337043 0.9009369569556706 0.03461006336664197 3.351533484775388e-06 2.11986740046368e-07 0.033511816942096886 0.011170349919182317 3.481234100886892e-11 10.458266770940108 -0.22141649547281106 MEEFKDQLPADECNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEEFKDQLPADECNK 15 1 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 9517710.0 4062800.0 677410.0 4777500.0 False True 3933828.6378642838 947903.3456464825 3526129.428072172 1.0 0.2409620328965598 0.8963607092927526 21.907502682840978 -10.665910676976567 9.319655820651032 1.0003320632770847 0.5686613710951638 0.3660921696793773 0.26756538921102424 0.0018474165070146587 6.622570820906249e-05 0.25925534500432684 0.08635635803631696 2.1581882464202718e-11 10.665910676976567 -0.4316706921819209 MEELHNQEMQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEELHNQEMQK 11 0 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 9809950.0 2574400.0 927460.0 6308090.0 False True 2492677.081155315 1297799.6146400047 4655811.990356416 1.0 0.5206449020017049 1.867795883211043 21.249264567440076 -6.810500572223012 1.4123275884675357 0.7389022146427209 1.8916545165417975 0.8611380805579711 0.20776305348250865 0.20613024279478392 0.8102543750573573 0.11566423997424606 0.26750752715190784 1.5470324655887017e-07 6.810500572223012 1.1527523018990766 MEELHNQEMQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEELHNQEMQKR 12 1 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 2799580.0 1026400.0 1266200.0 506980.0 True False 993817.4938229546 1771800.2631457704 374186.72892601293 1.0 1.7828225747265936 0.3765145323480018 19.92262141180631 -6.755570798071282 1.6287957788321505 1.457173671092977 0.3723937066915143 0.6728524600102729 0.3290818085275617 0.29037500499167157 1.5171542816433679 0.1594835100507469 0.3850117921864522 1.755614673052842e-07 6.755570798071282 -1.0847799644014628 MEELHNQEMQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MEELHNQEMQKR 12 1 P23246;P23246-2;H0Y9K7 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 3148930.0 1026400.0 1621100.0 501430.0 True False 853497.077229709 1612366.8125368436 606276.6946496322 1.0 1.8891298582653417 0.7103441954569925 19.703026687240587 -6.7049549630760765 1.8133306147758634 1.5494246463544306 0.7135253980024048 0.4410183949110128 0.37498557929493775 0.38532591701139524 2.466569723306113 0.16477042702175715 0.42115292695802203 1.972627289620744e-07 6.7049549630760765 -0.8358992483520258 MEELHNQEVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEELHNQEVQK 11 0 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 18570850.0 5033250.0 1411900.0 12125700.0 False True 4873472.233811759 1975679.0329612338 8949615.406797428 1.0 0.4053945396988478 1.836394048724791 22.216518594105423 -6.793881163666752 1.48107086035909 0.669346034980783 1.853221775438905 0.8135732154529347 0.2534397299204535 0.22961457077571076 0.9949355970262976 0.1346706581225734 0.3143908161916267 1.6073810217487738e-07 6.793881163666752 1.183875740458122 MEELHNQEVQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 MEELHNQEVQKR 12 1 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 9802300.0 2633700.0 4040000.0 3128600.0 True False 3452806.2047870834 3437247.7477966547 2804882.4836503244 1.0 0.9954939674955235 0.8123486570898603 21.719337931827475 -6.912189271001695 0.8806808264575472 1.0052855056203196 0.7875363635151366 0.9917221185022742 0.007953443947934671 0.10298840751645306 0.1310415489993937 0.006582907586143563 0.018459944977370184 1.2240826123915018e-07 6.912189271001695 -0.21774914210518304 MEELHNQEVQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEELHNQEVQKR 12 1 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 10405900.0 2226100.0 3367100.0 4812700.0 True False 2155433.6740055336 4711600.589194536 3552109.4920948027 1.0 2.185917686086239 1.647979028505093 21.039546738588193 -10.136865905159254 5.448181752585447 0.9999818102826822 1.9169483572959083 0.7948309717534467 0.21961253733278172 4.852380408838013e-05 7.687661373858524e-06 0.21264313102676513 0.07087964164222789 7.296827758184718e-11 10.136865905159254 0.9169665470132261 MEELHNQEVQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 MEELHNQEVQKR 12 1 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 35820200.0 4499300.0 7537300.0 23783600.0 True False 6825767.042890143 6192209.925806311 19082761.035277784 1.0 0.9071815499851028 2.7956947424912157 22.70255974675506 -6.8953446259450395 0.9902455325943491 0.9111424685829876 2.97619557779716 0.9841039217531397 0.10958874780480272 0.11491308685110643 0.19738132906430522 0.08367570520773975 0.2130419500315097 1.2724929182494225e-07 6.8953446259450395 2.0650531092141726 up MEELHNQEVQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MEELHNQEVQKR 12 1 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 8969000.0 2633700.0 2878400.0 3456900.0 True False 3607450.063066339 2751222.770404078 2640451.417090306 1.0 0.7626502716064026 0.7319439967093869 21.782547993350367 -13.999999999999998 0.28830235750336874 3.025800983938128 0.7234323829714568 0.9996236624266667 0.0023237145675121247 15.865813345122746 0.17024019432504867 19.043809641961065 0.011686775074201353 1.0000000000000041e-14 13.999999999999998 -2.3023686009666715 MEELHNQEVQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MEELHNQEVQKR 12 1 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 11591200.0 2226100.0 4432400.0 4932700.0 True False 1851100.7829511454 4408521.781437488 5964104.76377209 1.0 2.381567671539275 3.221923311092617 20.81995201402247 -8.587112687890974 0.2050769826641338 1.710256222282125e-19 4.146910535239657 0.9996431962060203 0.017302972060990615 0.20310736868224094 0.056056828627602015 0.5275509861885647 0.4071203094834561 2.5875414297182618e-09 8.587112687890974 4.146910535239657 MEELHNQEVQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MEELHNQEVQKR 12 1 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 48099000.0 4499300.0 3890700.0 39709000.0 True False 5824432.544462267 3674179.124799828 32482369.44874707 1.0 0.6308218177053404 5.5769157254006725 22.47368606884751 -6.888916075117186 1.0287416166884327 0.7272948201999906 5.993450063910295 0.9801965600284211 0.31658120358481534 0.1200282964555725 0.2270041908474959 0.23479960326686553 0.5831385672362803 1.2914688183393123e-07 6.888916075117186 5.266155243710305 up MEEQGLADASLLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEEQGLADASLLKK 14 1 Q9UBB4;Q9UBB4-2;B1AHE3 Q9UBB4 ATXN10 Ataxin-10 1 9783200.0 2781600.0 3534700.0 3466900.0 True False 2693299.6305708583 4946124.143216994 2558814.8852293887 1.0 1.8364552116946 0.9500669202137881 21.360943308444256 -6.659269446805331 1.975654908006334 1.5387397001323584 0.953778116296158 0.23247999983602086 0.35620577607667203 0.4861458405211684 3.6470128045699295 0.14571106544828813 0.39479838596719674 2.1914448880553306e-07 6.659269446805331 -0.5849615838362003 MEEQGLADASLLK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MEEQGLADASLLKK 14 1 Q9UBB4;Q9UBB4-2;B1AHE3 Q9UBB4 ATXN10 Ataxin-10 1 7801500.0 2781600.0 3374600.0 1645300.0 True False 2313023.6457737307 3356420.3599943467 1989324.6229923174 1.0 1.451096432207717 0.8600537338332602 21.141348583878532 -6.702655719026665 1.820920032162847 1.279364882915584 0.8616905353604525 0.43047860303490637 0.1903203628686545 0.3899866788928176 2.5156565223867577 0.0833167714256571 0.21360717141821334 1.9830984768738622e-07 6.702655719026665 -0.41767434755513144 MEESFSSK(ub)YVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MEESFSSKYVPK 12 1 G5E972;P42167;P42167-2;H0YJH7 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 28833300.0 11013600.0 11783000.0 6036700.0 True False 14438936.255854113 10025022.329774274 5412080.192115306 1.0 0.6943047709425086 0.374825409310955 23.783461124239025 -7.090002040489806 0.25845025927517973 1.0975107415965197 2.06961071052155e-10 0.999979485553946 0.0011560732691892309 0.07543076303608649 0.00991268642943578 0.007874829632332664 0.030989613290948216 8.128266971690272e-08 7.090002040489806 -1.0975107413895586 down MEESFSSK(ub)YVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEESFSSKYVPK 12 1 G5E972;P42167;P42167-2;H0YJH7 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 16576600.0 5606800.0 5223100.0 5746700.0 True False 5428815.203007161 7308711.068106679 4241466.872695419 1.0 1.3462810566950585 0.7812877606049219 22.372205944655228 -6.740853649984717 1.683401538185334 1.2058352007504094 0.7808853441287106 0.6087821237453537 0.14549098695232884 0.316303763681586 1.7602919938546162 0.0683603208039644 0.16760413699655566 1.816127564442305e-07 6.740853649984717 -0.4249498566216988 MEESFSSK(ub)YVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MEESFSSKYVPK 12 1 G5E972;P42167;P42167-2;H0YJH7 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 22116100.0 11013600.0 6207200.0 4895300.0 True False 15085625.551348818 5932945.379534533 3739130.9618681967 1.0 0.3932846774792222 0.24786051789107796 23.846671185761917 -13.999999999999998 0.20064628268818188 4.38096656581276 0.15401456163480506 0.9994869686027882 0.007378097987124418 12.54376232199485 0.1420305914629663 16.64834499532977 0.09215436264479882 1.0000000000000041e-14 13.999999999999998 -4.226952004177955 MEESFSSK(ub)YVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MEESFSSKYVPK 12 1 G5E972;P42167;P42167-2;H0YJH7 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 17828600.0 5606800.0 8967100.0 3254700.0 True False 4662302.623354968 8918792.452470005 3935242.7219674825 1.0 1.9129587186796746 0.8440556179803925 22.152611220089504 -6.68052893651399 1.899826290526389 1.5773719357666354 0.848094486865312 0.3265439863932724 0.3868905367381009 0.4373984527912343 3.052706962285922 0.16337215549867506 0.4306200249748916 2.0867530814582817e-07 6.68052893651399 -0.7292774489013234 MEESHQEATEK(ub)EVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 MEESHQEATEKEVER 15 1 Q9NXX6;Q9NXX6-2 Q9NXX6 NSMCE4A Non-structural maintenance of chromosomes element 4 homolog A 1 27564300.0 4110700.0 7348600.0 16105000.0 True False 5389167.508075433 6252217.524618444 14438609.090068556 1.0 1.160145331398545 2.6791910009167332 22.36163099912364 -6.927071891007725 0.7704416120310549 0.9742196986261739 2.9690030931169202 0.9959309561920545 0.0482667188984142 0.09418679651718216 0.08533749482983552 0.04323044939369102 0.13972547351707992 1.1828457369566402e-07 6.927071891007725 1.9947833944907463 up MEESHQEATEK(ub)EVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEESHQEATEKEVER 15 1 Q9NXX6;Q9NXX6-2 Q9NXX6 NSMCE4A Non-structural maintenance of chromosomes element 4 homolog A 1 33292300.0 6264600.0 6751700.0 20276000.0 True False 6065733.702068667 9447689.01965037 14965107.333038477 1.0 1.5575509054128631 2.467155346423262 22.53225073145736 -6.963824234315768 0.3776942940911853 0.9358763621738848 3.120878134794721 0.9998868100717518 0.006433279487044675 0.07836232580907487 0.01628131581746367 0.011867256637334872 0.07694682808418353 1.0868654058334292e-07 6.963824234315768 2.1850017726208364 MEESHQEATEK(ub)EVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 MEESHQEATEKEVER 15 1 Q9NXX6;Q9NXX6-2 Q9NXX6 NSMCE4A Non-structural maintenance of chromosomes element 4 homolog A 1 40608000.0 10496000.0 15153000.0 14959000.0 True False 15923199.360383833 12448828.759070616 12002347.093237396 1.0 0.7818044902485309 0.7537647944733185 23.924626901953967 -13.999999999999998 0.28926488246871923 2.8724192690329993 0.746067132616115 0.9996258149499339 0.002129060274766641 15.9221717659076 0.17054162454004615 17.733400571498773 0.010625148385122709 1.0000000000000041e-14 13.999999999999998 -2.1263521364168843 MEESHQEATEK(ub)EVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MEESHQEATEKEVER 15 1 Q9NXX6;Q9NXX6-2 Q9NXX6 NSMCE4A Non-structural maintenance of chromosomes element 4 homolog A 1 23242200.0 6264600.0 1708900.0 15268700.0 True False 5209292.468835964 1699693.8165099092 18461314.57550772 1.0 0.3262811267898944 3.5439197714374 22.312656006891636 -6.852036677507258 1.2251376598015677 0.6397348803260345 3.6777511193950176 0.9432254582062685 0.33014911184039686 0.15523323398488156 0.44733231110075233 0.21074450332990433 0.48837812611870834 1.4059287840978716e-07 6.852036677507258 3.038016239068983 up MEESHQEATEK(ub)EVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MEESHQEATEKEVER 15 1 Q9NXX6;Q9NXX6-2 Q9NXX6 NSMCE4A Non-structural maintenance of chromosomes element 4 homolog A 1 25608900.0 10496000.0 7063500.0 8049400.0 True False 13587278.907091323 6670410.015684479 6584491.79381866 1.0 0.4909305285698619 0.48460709748014036 23.695753224046417 MEFSK(ub)AAVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEFSKAAVSR 10 1 O75150-3;O75150;H3BP71;O75150-4;H3BS50 O75150-3 RNF40 E3 ubiquitin-protein ligase BRE1B 1 11368700.0 0.0 2429600.0 8939100.0 True False 0.0 3399751.9501966177 6597681.542748284 0.0 MEFSK(ub)AAVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MEFSKAAVSR 10 1 O75150-3;O75150;H3BP71;O75150-4;H3BS50 O75150-3 RNF40 E3 ubiquitin-protein ligase BRE1B 1 9353500.0 0.0 5743100.0 3610400.0 True False 0.0 5712160.780383904 4365317.947396507 0.0 MEFSK(ub)AAVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MEFSKAAVSR 10 1 O75150-3;O75150;H3BP71;O75150-4;H3BS50 O75150-3 RNF40 E3 ubiquitin-protein ligase BRE1B 1 9507400.0 2317500.0 3135100.0 4054800.0 True False 3000049.434754585 2960628.9290256095 3316868.0057614096 1.0 0.9868600479471099 1.105604450158916 21.516554842941225 -6.879443080299374 1.082863098888536 0.991913867005616 1.113931687788598 0.9732350616541832 0.0086954866028035 0.12812624908914885 0.27525602639640245 0.0061886643421832505 0.014945293568452473 1.3199482960340353e-07 6.879443080299374 0.12201782078298207 MEIQVK(ub)DLSQQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MEIQVKDLSQQIR 13 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 57732600.0 18543200.0 20692000.0 18497400.0 True False 24310314.772604246 17604834.256784286 16583466.487589844 1.0 0.7241713824546405 0.6821576208580428 24.535065237871684 -13.999999999999998 0.2649358449355901 3.072237594065941 0.667512657284882 0.9995725589416089 0.002914641893231309 14.640902191113302 0.1629019727707917 16.291409719005337 0.017902310836314647 1.0000000000000041e-14 13.999999999999998 -2.4047249367810593 MEIQVK(ub)DLSQQIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEIQVKDLSQQIR 13 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 89292900.0 25626400.0 25253100.0 38413400.0 True False 24812903.959182154 35336794.52317677 28351778.162701745 1.0 1.4241297423835064 1.1426223310798738 24.56458725403045 -10.388478523665425 5.261667987058873 0.9998283119189553 1.283376036731699 0.5746659497720674 0.11492491941764695 0.00023160110014645293 2.691725973886183e-05 0.1113425079042115 0.037091858247393465 4.08809967708899e-11 10.388478523665425 0.2835477248127438 MEIQVK(ub)DLSQQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MEIQVKDLSQQIR 13 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 139427600.0 38797300.0 34048000.0 66582300.0 True False 58858340.562559016 27971868.381761786 53422279.2209412 1.0 0.4752405201099954 0.9076416139214805 25.81074353207742 -10.041717345808703 7.231280941822413 1.000000036284992 0.6914410670157396 0.404391658049002 0.17652700734324345 1.0322940688873875e-07 1.3736193071315343e-08 0.17092156027442784 0.05697384663301801 9.084115641621577e-11 10.041717345808703 -0.3085589692692523 MEIQVK(ub)DLSQQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MEIQVKDLSQQIR 13 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 54681200.0 18543200.0 20145000.0 15993000.0 True False 25399122.151137825 19254927.28939345 12215782.786174107 1.0 0.7580942039971595 0.480952952369138 24.598275299394576 -6.969348934799757 0.2732931586262428 1.0662022397006439 0.16447637369601134 0.9999768475066954 0.0010203668481424692 0.07651456191472489 0.00978395536529352 0.0053251884562415105 0.02566075490990557 1.0731268598826956e-07 6.969348934799757 -0.9017258660046326 down MEIQVK(ub)DLSQQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MEIQVKDLSQQIR 13 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 88247600.0 31738700.0 39808900.0 16700000.0 True False 26392135.31281233 39594441.55425199 20191892.787924208 1.0 1.500236380458025 0.7650723425217455 24.653604743961743 -6.7235157874283376 1.7469545289723403 1.303194396747348 0.7660078829119994 0.5289333817690747 0.21041552512182626 0.3485262694129437 2.0805964261414425 0.09557409742110873 0.2389140452828022 1.8900975213073482e-07 6.7235157874283376 -0.5371865138353487 MEIQVK(ub)DLSQQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MEIQVKDLSQQIR 13 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 137213400.0 38797300.0 32798600.0 65617500.0 True False 50223869.65911719 30973329.07771346 53675788.292406306 1.0 0.6167053492281203 1.0687306385732165 25.58186985416987 -6.6820293022365345 1.8948991146760765 0.757926168806037 1.067029502498606 0.3333639417918034 0.16237797896478537 0.43401518808556266 3.0147851495817686 0.0687200108587918 0.1807598713632192 2.079556372844591e-07 6.6820293022365345 0.30910333369256904 MEITIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MEITIR 6 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;Q9UQ88-9;A0A087WYI9;A0A087X1I0 P21127 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 5443200.0 1453900.0 2449900.0 1539400.0 False True 1906076.9795876273 2084384.4696354063 1380117.6549674969 1.0 1.0935468461962932 0.7240618662033682 20.86217495500785 -6.839587381773827 1.284215232678613 1.0497694803209112 0.7120011074300345 0.9237560104558888 0.04330939748955109 0.16928239141787693 0.5424775320510142 0.026445359007557852 0.0609216195494374 1.4468137191433858e-07 6.839587381773827 -0.3377683728908767 MEK(ub)GEPYMSIQPAEDPDDYDDGFSMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEKGEPYMSIQPAEDPDDYDDGFSMK 26 1 Q969G3;Q969G3-2;A0A2R8Y855;A0A2U3TZQ7;Q969G3-4;Q969G3-3;Q969G3-5;Q969G3-6;B4DGM3;A0A2R8YES3;A0A2R8Y4T4;A0A2R8Y7I9;A0A2R8Y765;A0A2R8Y7U4;J3QKS7;J3QR61 Q969G3 SMARCE1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 1 11136100.0 3762200.0 4181900.0 3192000.0 True False 3642771.0203241617 5851754.4783204 2355919.4420526167 1.0 1.6064019521599429 0.6467382739426122 21.796604881389445 -6.735939701324861 1.701655922140991 1.3624936277141135 0.6466688909997568 0.5865503484839563 0.2548200497054505 0.3252066427868496 1.847365629514912 0.11854704836968322 0.2921998792993903 1.8367933512328597e-07 6.735939701324861 -0.7158247367143568 MELLAHLLGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MELLAHLLGEK 11 0 Q9Y2Q3;Q9Y2Q3-4;Q9Y2Q3-3;Q9Y2Q3-2 Q9Y2Q3 GSTK1 Glutathione S-transferase kappa 1 0 2150700.0 0.0 1147500.0 1003200.0 False True 0.0 976297.4729199659 899398.4873739076 0.0 MELLAHLLGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MELLAHLLGEK 11 0 Q9Y2Q3;Q9Y2Q3-4;Q9Y2Q3-3;Q9Y2Q3-2 Q9Y2Q3 GSTK1 Glutathione S-transferase kappa 1 0 4812500.0 1920000.0 1041400.0 1851100.0 False True 1859050.6509548638 1457236.450829255 1366241.3781903489 1.0 0.7838605419818846 0.7349134772033278 20.82613464721251 -13.999999999999998 0.2086809594886998 2.2432843718186133 0.7057123300041381 0.9994893113655151 0.0026027168141511473 12.7161176056785 0.14480042344846653 6.478093198300297 0.029264062139615698 1.0000000000000041e-14 13.999999999999998 -1.5375720418144752 MELLAHLLGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MELLAHLLGEK 11 0 Q9Y2Q3;Q9Y2Q3-4;Q9Y2Q3-3;Q9Y2Q3-2 Q9Y2Q3 GSTK1 Glutathione S-transferase kappa 1 0 6212900.0 0.0 3456000.0 2756900.0 False True 0.0 3303302.4925363 2105777.0001377705 0.0 MELVQVLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 MELVQVLKR 9 1 Q9UI09;F8VXI1;F8VRD8;Q9UI09-2 Q9UI09 NDUFA12 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 1 20372300.0 2173000.0 7113200.0 11086100.0 True False 2848824.0433619367 6051938.287036436 9939016.71738026 1.0 2.124363665470353 3.488813828477482 21.441935086174244 -6.968539495676895 0.29096218281389574 0.7364452577594739 4.9189448782916525 0.9999686443011027 0.005698326566985209 0.07677949741479692 0.010717643947430766 0.023715121878130265 0.12359734809381061 1.0751288214127604e-07 6.968539495676895 4.1824996205321785 MELVQVLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 MELVQVLKR 9 1 Q9UI09;F8VXI1;F8VRD8;Q9UI09-2 Q9UI09 NDUFA12 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 1 23681100.0 4689900.0 16101900.0 2889300.0 True False 4541021.691621467 22531472.64029922 2132505.652857964 1.0 4.961762830129509 0.46960921961518054 22.11458549759049 -6.673841037143705 1.9237412523589705 3.520298898822917 0.4873605238019956 0.2962976559514954 1.6813780512684893 0.45227815828911055 3.2304444738418554 0.7027232636624307 1.8681579907397197 2.1191366513697643e-07 6.673841037143705 -3.032938375020921 MELVQVLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MELVQVLKR 9 1 Q9UI09;F8VXI1;F8VRD8;Q9UI09-2 Q9UI09 NDUFA12 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 1 11737700.0 2173000.0 3434900.0 6129800.0 True False 2976416.8231169665 3283134.76030467 4682067.487193778 1.0 1.103049389724421 1.5730550408227495 21.505145147697135 -6.941874789318297 0.6418906511488257 0.9948475121955759 1.7071087116272112 0.9983992339904727 0.00997939606091329 0.0869217643049159 0.050793308646238246 0.009858149251639222 0.04013018746125304 1.1432078835450216e-07 6.941874789318297 0.7122611994316354 MEMAFNTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MEMAFNTR 8 0 E9PCB6;Q9BYT8 E9PCB6 NLN Neurolysin, mitochondrial 0 8088400.0 2990100.0 1573800.0 3524500.0 False True 3920050.0561695886 1338995.1746243525 3159818.5493912883 1.0 0.34157603995820635 0.8060658675565108 21.90244064594184 -10.366368650444647 9.881637730195601 1.0000002334944864 0.5738209537575797 0.5288483904673034 0.18962717805486223 9.753339975123365e-07 6.27113406490868e-08 0.18360582550528443 0.061201908549565844 4.301613134639587e-11 10.366368650444647 -0.4261792797369067 MEMAFNTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MEMAFNTR 8 0 E9PCB6;Q9BYT8 E9PCB6 NLN Neurolysin, mitochondrial 0 6103500.0 2990100.0 1254000.0 1859400.0 False True 4095620.774414188 1198594.1335765384 1420248.0155450604 1.0 0.2926526159512358 0.346772343869704 21.965650707464732 -10.45486940644456 9.34440282012517 1.0000054799001865 0.31971247991046997 0.9952757711634254 0.02209428640308404 2.522382110725489e-06 1.471365677929934e-07 0.021392872662553807 0.007130900273790121 3.5085736187351044e-11 10.45486940644456 -0.6802929999897165 MEMAFNTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MEMAFNTR 8 0 E9PCB6;Q9BYT8 E9PCB6 NLN Neurolysin, mitochondrial 0 3890410.0 2292100.0 993790.0 604520.0 False True 1905982.7072468987 988436.2560181301 730922.3370153258 1.0 0.5185966547649739 0.3834884410211194 20.862103599231883 -13.999999999999998 0.17824529593503674 3.484557407522358 0.27419810208392853 0.9995003592107851 0.005914373464960549 12.18251900829427 0.1338201136632701 10.478751139421204 0.10240120588174931 1.0000000000000041e-14 13.999999999999998 -3.2103593054384296 MEPDETVK(ub)VLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MEPDETVKVLK 11 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 18722100.0 1862500.0 13609600.0 3250000.0 True False 2441755.5364756584 11579100.729805307 2913721.176201354 1.0 4.742121214361272 1.1932894725435592 21.219487337229847 -6.63367627997065 2.0668136674746944 3.4586733215609637 1.2076634899301253 0.13100150135111222 1.6036697038717629 0.5494851082701867 4.477704743567506 0.6335224825745993 1.7765303509341266 2.324468793334877e-07 6.63367627997065 -2.2510098316308387 MEPDETVK(ub)VLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEPDETVKVLK 11 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 21309000.0 15839700.0 1170400.0 4298900.0 True False 15336877.393713417 1637746.8235553685 3172889.125764406 1.0 0.10678489378983239 0.2068797346626095 23.870501442542498 -10.410851990174754 6.914114703141343 1.0000711992743814 0.1568323142262348 0.9895409909124936 0.040863547670563674 4.485260796646978e-05 3.821881249710034e-06 0.03956924959607793 0.013188653299587157 3.882826722044904e-11 10.410851990174754 -0.8432388850481466 MEPDETVK(ub)VLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MEPDETVKVLK 11 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 19987900.0 1862500.0 13271800.0 4853600.0 True False 2551116.582169972 12685407.992026396 3707279.6430297415 1.0 4.97249246886092 1.4531988341655249 21.282697398752738 -6.617012744492623 2.127660051974079 3.64135700921554 1.46638520998425 0.0728390778925957 1.7096119904003844 0.5934997510562093 5.101085960947966 0.6611846786679111 1.8963384739236953 2.41538995311351e-07 6.617012744492623 -2.1749717992312902 MEPDETVK(ub)VLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MEPDETVKVLK 11 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 20501600.0 15839700.0 2272500.0 2389400.0 True False 13171412.367688444 2260257.59144407 2889012.492662644 1.0 0.1716032820435293 0.2193396130964549 23.650906717976774 -10.25197904991371 5.547148473493293 1.000057036902794 0.1954714475700306 0.997366512665928 0.019488275545479685 1.3747835667815822e-05 1.8538386308202312e-06 0.018870769322704845 0.006289813886146652 5.5978460449283925e-11 10.25197904991371 -0.8045855893327634 MEPDETVK(ub)VLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MEPDETVKVLK 11 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 33900300.0 4457700.0 17189600.0 12253000.0 True False 5770580.524403678 16232983.649127172 10023079.726397002 1.0 2.8130590294127575 1.7369274519278577 22.460285031617698 -10.359882143580325 5.770581903277763 0.9997419788158306 2.274993240670311 0.6517676831984109 0.439328876822403 0.0014586435349599903 0.0001618042738534715 0.4254593778391351 0.14179278528676287 4.3663430755239187e-11 10.359882143580325 1.2752512618544805 MEQELK(ub)EPGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 MEQELKEPGR 10 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 308942200.0 116868370.0 112995830.0 79078000.0 True False 153215564.82490516 96137292.61829554 70895767.12973881 1.0 0.6274642705404069 0.46271909261150157 27.190987623953628 -13.9999999999999 0.11064906380978756 2.7955261042891837 0.16330470830563895 0.9997397668319968 0.0036255313383783674 12.008861648829065 0.10104530512184129 4.811299699384868 0.26590054907706817 1.0000000000002291e-14 13.9999999999999 -2.6322213959835445 MEQELK(ub)EPGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MEQELKEPGR 10 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 302342780.0 111902920.0 95962720.0 94477140.0 True False 108350623.05716161 134281134.5349737 69730742.78055346 1.0 1.2393203725661288 0.6435656834549646 26.691132208597793 -6.797697959472594 1.465509658296208 1.132431672285011 0.6358214681842066 0.8252837372930055 0.10231464322979487 0.22406231534880683 0.950307790152785 0.05493211940995105 0.12792293854354583 1.5933164520010097e-07 6.797697959472594 -0.49661020410080436 MEQELK(ub)EPGR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MEQELKEPGR 10 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 651600000.0 290984900.0 232159100.0 128456000.0 True False 441445367.145708 190728494.73767278 103066615.29573499 1.0 0.43205458462704616 0.23347535837139222 28.717659661468655 -13.999999999398785 0.14650609835778233 3.7325574100274017 0.005972535517757128 0.9995783172088977 0.006670090876697507 11.946323456782968 0.12035521586518279 9.303930784857707 0.204403732689873 1.0000000013843488e-14 13.999999999398785 -3.7265848745096446 MEQELK(ub)EPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MEQELKEPGR 10 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 288456980.0 116868370.0 76947110.0 94641500.0 True False 160077764.63794675 73547332.25013445 72289126.9028761 1.0 0.45944752174968784 0.4515875584993009 27.25419768547652 MEQELK(ub)EPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MEQELKEPGR 10 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 369128720.0 111902920.0 175200000.0 82025800.0 True False 93052236.11990455 174256162.8255229 99177015.53555192 1.0 1.872670341860256 1.0658208729960572 26.47153748403207 -10.43294162478536 4.3327305145086275 0.9983625703918475 1.4692456074287563 0.3108090714028239 0.3293949163317747 0.0052307548860273355 0.0006845901067828351 0.319962256094316 0.10631175210564407 3.6902719762115454e-11 10.43294162478536 0.4708830370369088 MEQELK(ub)EPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MEQELKEPGR 10 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 618272600.0 290984900.0 229638400.0 97649300.0 True False 376685689.2199006 216858821.17162317 79878129.36642925 1.0 0.5757023093198157 0.21205512089363768 28.488785983561105 -7.811893054743194 0.3226201384746703 1.0924116753401285 1.0170513777250137e-11 0.9991669408049269 0.009293653820789713 0.11627149221258112 0.053001184606805744 0.04030282047251559 0.08207565568623848 1.542080144288017e-08 7.811893054743194 -1.092411675329958 down MESQLQNDSK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 MESQLQNDSKK 11 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 12453600.0 651980.0 556920.0 11244700.0 True False 989101.3261226241 457533.2747641791 9022180.116272913 1.0 0.4625747258450812 9.121593387849108 19.915758796439093 -6.892122109173508 1.0097668335877223 0.5581321107579901 9.898003471052613 0.9822214087837844 0.5281865948960565 0.11743737593518541 0.21193598994394017 0.39741481563285713 0.9986169417787548 1.2819700845998756e-07 6.892122109173508 9.339871360294623 up METIVFLDK(ub)EVFASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 METIVFLDKEVFASR 15 1 Q9NV79;A0A0G2JM70;Q9NV79-2;V9GYG6;V9GZ41;Q9NV79-3 Q9NV79 PCMTD2 Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 1 4497900.0 1884500.0 1612800.0 1000600.0 True False 2470597.7495239624 1372176.526645161 897067.5104329466 1.0 0.5554026457401062 0.3630973559357425 21.236428706657318 -13.999999999974607 0.11418689534209263 3.1315835983068805 0.03066985076446297 0.9997218745263113 0.004448239659046831 11.989709296124778 0.10320038294295264 5.849338208827927 0.2950374670247347 1.0000000000584696e-14 13.999999999974607 -3.1009137475424176 METIVFLDK(ub)EVFASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 METIVFLDKEVFASR 15 1 Q9NV79;A0A0G2JM70;Q9NV79-2;V9GYG6;V9GZ41;Q9NV79-3 Q9NV79 PCMTD2 Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 1 25234500.0 9705300.0 10425000.0 5104200.0 True False 9397210.56391263 14587756.865656804 3767256.8972822577 1.0 1.552349685733022 0.40089097415241054 23.163801144962147 -6.7762612264737045 1.5503107934015692 1.314280569394403 0.39279973798939977 0.7539461824564716 0.2332422001737588 0.25644668704174356 1.2171187616842838 0.1185256893788314 0.2805722759560078 1.6739357072121404e-07 6.7762612264737045 -0.9214808314050034 down METIVFLDK(ub)EVFASR ddPTM_RPMI8226_Bortezomib_8h_R1 1 METIVFLDKEVFASR 15 1 Q9NV79;A0A0G2JM70;Q9NV79-2;V9GYG6;V9GZ41;Q9NV79-3 Q9NV79 PCMTD2 Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 1 28912400.0 14878000.0 7523500.0 6510900.0 True False 22571013.72749531 6180872.643626203 5224017.761171152 1.0 0.27384116275189074 0.23144807868365325 24.427967879674707 -13.618158270541677 0.40770003388375853 9.999999999951001 0.2293568882442307 0.9998416618883919 0.004438504494140112 20.195196147618567 0.21089744362011797 159.3347229692357 0.010625955253500153 2.4090273435122466e-14 13.618158270541677 -9.77064311170677 METIVFLDK(ub)EVFASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 METIVFLDKEVFASR 15 1 Q9NV79;A0A0G2JM70;Q9NV79-2;V9GYG6;V9GZ41;Q9NV79-3 Q9NV79 PCMTD2 Protein-L-isoaspartate O-methyltransferase domain-containing protein 2 1 27881800.0 14878000.0 7293500.0 5710300.0 True False 19259864.289224926 6887610.31349822 4671083.992625872 1.0 0.3576146856523566 0.24252943439685315 24.199094201767156 -13.999999999999998 0.24185564898090803 5.290529987500814 0.19253318597769506 0.9995280778185699 0.007240041938655578 13.689667099428947 0.15564327196781777 28.39843126157269 0.055628406033810356 1.0000000000000041e-14 13.999999999999998 -5.097996801523119 MEVDEAEKK(ub)EEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MEVDEAEKKEEK 12 2 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 6176100.0 1625830.0 2566780.0 1983490.0 True False 2131478.874560119 2183826.429230078 1778257.4817795781 1.0 1.0245592650693112 0.8342834184301092 21.02342332590757 -6.874457674438922 1.1102017595766014 1.0143458901619766 0.8221514886903463 0.9689351729138979 0.014894209953207227 0.1326547980182664 0.3028943133088547 0.010380621277263984 0.024786240760026557 1.335187708220407e-07 6.874457674438922 -0.19219440147163036 MEVDEAEKK(ub)EEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEVDEAEKKEEK 12 2 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 3948120.0 429170.0 2364150.0 1154800.0 True False 415546.23326578084 3308167.423879383 852323.2367425935 1.0 7.961009291025144 2.0510912348890256 18.664649473195638 -6.606129628171875 2.167590128259287 5.662527244734217 2.071250486651903 0.038699439422513526 3.0040334513271905 0.6233524521368347 5.543935710456643 1.1466032617119328 3.338121789180227 2.476682707300797e-07 6.606129628171875 -3.591276758082314 MEVDEAEKK(ub)EEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MEVDEAEKKEEK 12 2 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 9558880.0 7701200.0 1028810.0 828870.0 True False 11683283.43313529 845210.8173707812 665043.481193373 1.0 0.07234360290991956 0.056922652351925694 23.477942445878462 MEVDEAEKK(ub)EEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MEVDEAEKKEEK 12 2 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 4955420.0 1625830.0 1957190.0 1372400.0 True False 2226943.287403709 1870714.8742381716 1048267.3854652249 1.0 0.8400370520522561 0.47072028793663256 21.08663338743046 -6.957143515392676 0.47397903927116586 1.0093868648850792 0.28612842856815707 0.9996491458231008 0.0041515640897700585 0.08073774172777189 0.025024655427233748 0.005145368990024447 0.030473947811107998 1.1037138303286818e-07 6.957143515392676 -0.7232584363169221 down MEVDEAEKK(ub)EEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MEVDEAEKKEEK 12 2 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 3667350.0 429170.0 2292400.0 945780.0 True False 356873.870454671 2280050.3861942277 1143538.2252073633 1.0 6.388953002609455 3.2043204052749834 18.445054748629914 -9.457744138623067 9.476312911686577 0.9998073735031348 4.79663670394223 0.6545815053531124 1.3001208183739186 0.0 0.0 1.2588365672556627 0.41961218908522085 3.485425958487191e-10 9.457744138623067 3.7968293304390954 MEVDEAEKKEEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEVDEAEKKEEK 12 2 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 22610100.0 8156100.0 8243000.0 6211000.0 True False 7897189.069923429 11534472.886677127 4584152.773993986 1.0 1.4605795536295758 0.5804790455698731 22.912907800269394 -6.7644988996777675 1.5955468907167814 1.2660260081359056 0.5765285818812433 0.7090777488052937 0.19386642150289105 0.2754128680206555 1.3827968441382905 0.09582505754669904 0.2292705076285945 1.7198916987255108e-07 6.7644988996777675 -0.6894974262546623 MEVDEAEKKEEK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MEVDEAEKKEEK 12 2 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 16569000.0 5859500.0 5411200.0 5298300.0 True False 8025915.497033529 5172115.291554526 4046950.6619137335 1.0 0.6444268312401494 0.5042353938824217 22.9362345357271 -13.999999999999998 0.1285652770068602 2.689588656844232 0.30428216120687773 0.9996521587158115 0.003891696705157078 11.939162323679847 0.11135931930938145 5.104282192066114 0.17773521904530779 1.0000000000000041e-14 13.999999999999998 -2.385306495637354 MEVDEAEKKEEK(ub)EK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MEVDEAEKKEEKEK 14 3 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 3996500.0 1495800.0 1085900.0 1414800.0 True False 1448316.647759525 1519505.5328936896 1044221.436909787 1.0 1.0491528459914412 0.7209897355838217 20.465945624929287 -6.868762110838276 1.140560474679695 1.027604027440301 0.7022124900140616 0.9634353597421583 0.027633436306591902 0.13805069720354068 0.3364096631642113 0.01881587100052121 0.044456191942341905 1.352813377387974e-07 6.868762110838276 -0.3253915374262395 MEVVVHGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MEVVVHGR 8 0 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 0 3926700.0 1323000.0 1310500.0 1293200.0 False True 1734465.8119502235 1114978.50828899 1159392.0692503357 1.0 0.6428368323013035 0.6684433104776634 20.726059973271635 -10.719953221560138 6.791238558866885 1.0043166628268296 0.6556400713894905 0.9958701091145764 0.01045380094029913 0.0006886671672774889 2.839816645524075e-05 0.010202252036232694 0.0033739497455288294 1.905665968740978e-11 10.719953221560138 -0.3486765914373391 MFAPTK(ub)TWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MFAPTKTWR 9 1 P36578;H3BM89;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 4677600.0 1001900.0 2640900.0 1034800.0 True False 833124.2416956797 2626672.9475223897 1251171.8956253873 1.0 3.152798605615236 1.5017830870925617 19.668172131507283 -6.579015976409519 2.271367784617202 2.466876963617105 1.505857579304506 0.0 0.9354755459814068 0.7021842917411606 6.812865256968273 0.34609568316932127 1.04562428470702 2.63623440477475e-07 6.579015976409519 -0.9610193843125989 MFEIVFEDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MFEIVFEDPK 10 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 2838230.0 907590.0 926840.0 1003800.0 False True 1189859.2791140638 788559.0847940245 899936.4051295151 1.0 0.6627330631746333 0.7563385191226838 20.182359529975944 -10.11366015566224 7.309912283659962 1.0000000963886975 0.7095357911486591 0.9277389701019013 0.03821426736888209 6.002201055259599e-08 7.3162939035046064e-09 0.03700081740651297 0.012333601758933154 7.697325361734378e-11 10.11366015566224 -0.2904643052400384 MFEIVFEDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MFEIVFEDPK 10 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 3037250.0 907590.0 1297900.0 831760.0 False True 1243150.549697528 1240554.4864186542 635315.4186349143 1.0 0.9979117064465721 0.5110526788485059 20.245569591498835 -6.907841103177756 0.9103129385053975 1.0161225664179914 0.4509558379628668 0.9900809940240102 0.02290680045542883 0.10586295332911752 0.1466400666241275 0.018556173577681037 0.05048856581527697 1.2363997165353673e-07 6.907841103177756 -0.5651667284551245 MFFLFPDPHFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MFFLFPDPHFK 11 0 Q9UBP6 Q9UBP6 METTL1 tRNA (guanine-N(7)-)-methyltransferase 0 3450640.0 1234900.0 1397600.0 818140.0 False True 1618965.858788611 1189083.527802132 733486.7209530388 1.0 0.7344710336831082 0.4530587948913693 20.626641131323076 -6.970389184516542 0.24871583718634732 1.0907297848856656 0.08857129359519941 0.9999852601688493 0.0008573585030396284 0.07617662525857224 0.008577138376510616 0.006331553289409945 0.02702764781219747 1.0705595142562456e-07 6.970389184516542 -1.0021584912904662 down MFFLFPDPHFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MFFLFPDPHFK 11 0 Q9UBP6 Q9UBP6 METTL1 tRNA (guanine-N(7)-)-methyltransferase 0 2984450.0 1062500.0 955310.0 966640.0 False True 1028771.5190830955 1336770.264875838 713447.9854215976 1.0 1.2993849849840808 0.6934950785354812 19.972491177516417 -6.772316570167482 1.565348508752641 1.1712047405056154 0.689763592370515 0.7394622158755155 0.12625931964684592 0.2626803884882031 1.2705369746835538 0.06356248928451237 0.15100057698582472 1.689209167949195e-07 6.772316570167482 -0.4814411481351004 MFFLFPDPHFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MFFLFPDPHFK 11 0 Q9UBP6 Q9UBP6 METTL1 tRNA (guanine-N(7)-)-methyltransferase 0 7109100.0 1234900.0 2490900.0 3383300.0 False True 1691475.9019176888 2380843.801695216 2584234.221250728 1.0 1.4075540768839598 1.5277984264043525 20.689851192845968 -12.056801283491383 0.20208494102003965 3.916811652529293e-08 1.6123871107912464 0.9994032341433695 0.005517577287537257 5.3933642207915256 0.12681872277514533 2.3239798137589385 0.07494312140257424 8.774021949239889e-13 12.056801283491383 1.6123870716231299 MFFLFPDPHFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MFFLFPDPHFK 11 0 Q9UBP6 Q9UBP6 METTL1 tRNA (guanine-N(7)-)-methyltransferase 0 1849290.0 1062500.0 786790.0 0.0 False True 883515.8267308708 782551.4061044117 0.0 1.0 0.8857242648385358 0.0 19.752896452950694 -7.133221252033247 0.9545808017857417 0.9959759755888531 8.26870425712167e-20 0.9896939404187157 0.045369870444926914 0.08652025930985584 0.14937669325121183 0.037803257348128144 0.06649273410910277 7.358321311080153e-08 7.133221252033247 -0.9959759755888531 down MFGIPVVVAVNAFK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MFGIPVVVAVNAFK 14 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 824925500.0 293981300.0 276442900.0 254501300.0 False True 445991125.0118905 227109504.63676408 204199006.50311774 1.0 0.5092242690495448 0.45785441694086093 28.732439760659886 -13.999999999999998 0.31885974595522587 5.9981780746755 0.44752567104578633 0.9996912770546841 0.004293587627952555 17.92513860836611 0.18002873528551125 59.730941924706244 0.01717941080894857 1.0000000000000041e-14 13.999999999999998 -5.550652403629713 MFGIPVVVAVNAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MFGIPVVVAVNAFK 14 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 17239800.0 1792000.0 4808800.0 10639000.0 False True 2454550.8269791063 4596331.31542493 8126287.317082881 1.0 1.872575326167428 3.3107024013367696 21.227027610573455 -6.963644828077958 0.3805940304206182 0.9018719664492633 4.33230964164008 0.9998824278557666 0.010330321162186816 0.07842388552099751 0.01650023932736829 0.01870453433117319 0.12148593637305843 1.0873144806484037e-07 6.963644828077958 3.430437675190817 MFGIPVVVAVNAFK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MFGIPVVVAVNAFK 14 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 727156600.0 293981300.0 303332300.0 129843000.0 False True 380564588.0877746 286451590.8544787 106212906.30168656 1.0 0.7527016433499868 0.27909298349427425 28.503566082752336 -6.97377026806393 0.42597802106811394 1.0197631691542188 1.2753404509893576e-18 0.9998029657477339 0.004198484997604366 0.07750321957611819 0.019990046537380034 0.006096820600990229 0.03841702527325753 1.0622573186477455e-07 6.97377026806393 -1.0197631691542188 down MFHATVATENEVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MFHATVATENEVFR 14 0 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 0 22083600.0 7933600.0 6783500.0 7366500.0 False True 10401026.429091698 5771428.241875898 6604285.244457632 1.0 0.5548902583050072 0.6349647594381098 23.31022257249042 -10.802165271892644 7.192397585915427 1.0152977207878848 0.5949275088715584 0.9715266238643547 0.032690278197335824 0.00782015025761954 0.00021510144548236694 0.030867286584654974 0.010550741920097412 1.577011019855286e-11 10.802165271892644 -0.4203702119163264 MFHATVATENEVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MFHATVATENEVFR 14 0 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 0 18014900.0 7933600.0 4373000.0 5708300.0 False True 10866866.317478493 4179786.4004228176 4360117.106128784 1.0 0.3846358534566642 0.4012303987871721 23.373432634013312 -9.780819895598142 6.488276480477114 1.0000000074620747 0.3929331261694192 0.9994398866784729 0.006774694762896296 7.245330959268071e-10 1.5064895904506376e-10 0.006559569997778015 0.002186523332592699 1.6564567631293427e-10 9.780819895598142 -0.6070668812926555 MFIATFHFPHPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MFIATFHFPHPK 12 0 Q9H497;Q5W0C6;Q9H497-2 Q9H497 TOR3A Torsin-3A 0 5122670.0 2267800.0 2510400.0 344470.0 False True 2973107.7614064366 2135858.1054625562 308827.54878956376 1.0 0.7183924286861983 0.10387364790419573 21.50354032454052 -7.301502127721556 0.6046193698976114 1.0007969536917434 2.99095507636716e-22 0.996599501158651 0.02181883858223658 0.09965096621683169 0.06983732726077031 0.020772720530968427 0.06054314826097933 4.994567332338906e-08 7.301502127721556 -1.0007969536917434 down MFIATFHFPHPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MFIATFHFPHPK 12 0 Q9H497;Q5W0C6;Q9H497-2 Q9H497 TOR3A Torsin-3A 0 4939000.0 2184000.0 1328800.0 1426200.0 False True 2114670.1154611586 1859396.7696004563 1052635.4349171184 1.0 0.8792845541277093 0.4977776094819234 21.012001192523844 -6.950274379452943 0.5558246732870934 1.0051029708263886 0.3538566042737734 0.9992226294661544 0.005967934533180979 0.08337578007588356 0.035508053210435736 0.006430036345624637 0.03168557359359488 1.1213098070749054e-07 6.950274379452943 -0.6512463665526151 down MFIATFHFPHPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MFIATFHFPHPK 12 0 Q9H497;Q5W0C6;Q9H497-2 Q9H497 TOR3A Torsin-3A 0 7714300.0 2267800.0 2598700.0 2847800.0 False True 3106266.944990632 2483880.841248287 2175208.2922820384 1.0 0.7996353453311392 0.7002644430768967 21.56675038606341 -13.999999993531212 0.0914261563033972 2.0197815306165596 0.4573836977600141 0.9998356805694224 0.0015979758085936098 12.151073347467692 0.0882001474741077 2.3968201061769716 0.217949217681222 1.0000000148949354e-14 13.999999993531212 -1.5623978328565455 MFIGGLSWDTSK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MFIGGLSWDTSK 12 0 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 84403600.0 22572100.0 30264000.0 31567500.0 False True 29592241.68852733 25748729.168148063 28301197.916841924 1.0 0.8701175611893787 0.9563722212979244 24.81871565274823 -10.501819531436928 5.514543071838662 1.0001552592225442 0.9132448912436514 0.5742597719827178 0.03521331753385596 6.733649759859215e-05 6.0831382711426055e-06 0.034156037965648686 0.011365049364444726 3.149056614538483e-11 10.501819531436928 -0.08691036797889284 MFIGGLSWDTSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MFIGGLSWDTSK 12 0 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 81192000.0 32573000.0 15658000.0 32961000.0 False True 31538987.944558717 21910321.055391323 24327525.291195583 1.0 0.6947059015941384 0.7713476835071591 24.910633030402344 -10.369881586649683 5.616123668855462 1.000077204878491 0.7330267925506477 0.9417882854703576 0.03128887644410028 3.0255082837448534e-05 3.3945637100936627e-06 0.03030405496156418 0.01009844144912771 4.2669584447241344e-11 10.369881586649683 -0.2670504123278432 MFIGGLSWDTSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MFIGGLSWDTSK 12 0 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 80994000.0 25891000.0 26570000.0 28533000.0 False True 39278539.88564198 21828375.90764249 22893440.04354181 1.0 0.5557328752849522 0.5828485506384713 25.227237965073517 -10.70116597114775 6.733471307728146 1.0041878765899015 0.5692907129617174 0.9970362286220876 0.01106992810784728 0.0006997669019998933 3.1055898538755885e-05 0.010777159101775447 0.0035728039337838266 1.989912723256435e-11 10.70116597114775 -0.4348971636281841 MFIGGLSWDTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MFIGGLSWDTSK 12 0 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 81693900.0 22572100.0 25513500.0 33608300.0 False True 30917615.35806645 24386229.20813802 25670711.72466548 1.0 0.7887487092944772 0.8302940387660899 24.881925714271123 -10.474955741066248 6.099976116080899 1.000119423229173 0.8095213740302842 0.9655500941022662 0.016960809733543882 2.7563618742866276e-05 2.372472924017239e-06 0.016432483339176907 0.00547407780301733 3.3499957721217285e-11 10.474955741066248 -0.19059804919888879 MFIGGLSWDTSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MFIGGLSWDTSK 12 0 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 62826000.0 32573000.0 15977000.0 14276000.0 False True 27085892.72856906 15890928.729813807 17261045.595233895 1.0 0.5866865415535196 0.6372706917290443 24.69103830583662 -10.408215510070155 6.825641336552718 1.000035444228818 0.6119786166421154 0.9874142733488459 0.020650892833725253 1.1139630691157343e-05 9.657952867531694e-07 0.019996961305057976 0.0066650470024443385 3.906469968204782e-11 10.408215510070155 -0.38805682758670257 MFIGGLSWDTSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MFIGGLSWDTSK 12 0 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 100631000.0 25891000.0 45302000.0 29438000.0 False True 33516409.887909852 42780903.87634151 24080586.05938747 1.0 1.2764166573751556 0.7184715230515754 24.998364287165966 -6.772011460338762 1.5669291820691347 1.1581369468600657 0.7151039532225647 0.7381483886725502 0.11656000839305665 0.2631808630352464 1.2755572416958616 0.058626616709379374 0.13928978211064616 1.6903963241915666e-07 6.772011460338762 -0.44303299363750104 MFIGGLSWDTSK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 MFIGGLSWDTSKK 13 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 1 5045800.0 1726800.0 1827800.0 1491200.0 True False 2263851.5223549856 1555099.3647085973 1336904.9286004486 1.0 0.6869263948418736 0.5905444395972246 21.11034790956705 -13.999999999643066 0.16499906089891128 2.5592453804560775 0.5008346829982274 0.9995241200554332 0.003812944292028329 12.046752815834147 0.12851659299740947 6.010467462909712 0.0823063369725496 1.000000000821871e-14 13.999999999643066 -2.05841069745785 MFIGGLSWDTSK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 MFIGGLSWDTSKK 13 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 1 13424300.0 3076500.0 4870100.0 5477700.0 True False 4667275.422277134 4000992.6047350285 4395030.1940388 1.0 0.8572437327435392 0.9416693459017023 22.15414917453689 -10.178213267768717 4.695957493367816 1.0000139084236748 0.8994565393236198 0.654102265763101 0.034466612245607556 5.019511400805408e-06 8.78439788633713e-07 0.033376769674960276 0.01112405126860906 6.634172079774412e-11 10.178213267768717 -0.10055736910005497 MFIGGLSWDTSK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MFIGGLSWDTSKK 13 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 1 12683100.0 3076500.0 5579000.0 4027600.0 True False 3982589.8968813266 5268523.745664861 3294618.1266658404 1.0 1.3228888442142936 0.8272551811688618 21.92527549662934 -6.730859669099262 1.7198055883131156 1.1941196160840013 0.8274860478520334 0.5634171718787886 0.13572547336398638 0.3346075785959099 1.939207786187886 0.06252663487948487 0.155022008731225 1.8584048529976452e-07 6.730859669099262 -0.3666335682319679 MFIGGLSWDTSKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MFIGGLSWDTSKK 13 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 35457200.0 13628000.0 8805200.0 13024000.0 False True 17866439.973739732 7491498.4824007675 11676401.415029686 1.0 0.4193056083591272 0.6535382220628047 24.090748859089306 -10.271489679473243 5.632184459865053 1.0000365610273563 0.536421915210964 0.8392964140379514 0.09562506411543918 4.390383811515684e-05 5.678893513472937e-06 0.09259585200710801 0.03086285673325493 5.3519287188527524e-11 10.271489679473243 -0.4636146458163922 MFIGGLSWDTSKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MFIGGLSWDTSKK 13 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 23515900.0 12045000.0 4309200.0 7161700.0 False True 11662638.068099665 6029886.032181131 5285835.9236053275 1.0 0.5170259076009939 0.45322815410549844 23.475390824729825 -13.999999999999998 0.28531389977777294 5.053864232239649 0.43500736052121775 0.9996169889587514 0.004777331450879029 15.693242426878673 0.16929663582578308 37.23830145754139 0.024616398690429205 1.0000000000000041e-14 13.999999999999998 -4.618856871718431 MFIGGLSWDTSKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MFIGGLSWDTSKK 13 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 76407000.0 14597000.0 23083000.0 38727000.0 False True 22144716.183643565 18963658.3016978 31072591.47535291 1.0 0.8563513817216885 1.4031605199936414 24.400459171343375 -6.836889860920551 1.2967861156651708 0.9235257781327606 1.4200633455391107 0.9189692707771887 0.06588784682769591 0.17246280979892445 0.5647151397472145 0.039860153123505056 0.09176646672410607 1.4558282385116415e-07 6.836889860920551 0.49653756740635013 MFIGGLSWDTSKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MFIGGLSWDTSKK 13 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 34068000.0 13628000.0 10435000.0 10005000.0 False True 18666639.88285227 9973947.19606952 7642025.059443 1.0 0.5343193664560854 0.4093947870319816 24.153958920612197 -13.999999999999998 0.184674857712552 3.4521361444373873 0.31480712431247937 0.9994932386952862 0.005721008707714166 12.268830545492609 0.13626291921547637 10.808054933804552 0.08969563724916196 1.0000000000000041e-14 13.999999999999998 -3.1373290201249078 MFIGGLSWDTSKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MFIGGLSWDTSKK 13 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 16959300.0 12045000.0 2503500.0 2410800.0 False True 10015951.183974912 2490013.14859416 2914887.1337202266 1.0 0.24860476083170943 0.29102449484617293 23.2557961001641 -9.991249923808034 6.0100836472294406 1.0000006320636161 0.2698146278388518 0.99747516484688 0.0173177838936577 1.4664692358185117e-07 2.4653182594631073e-08 0.016767886643807517 0.0055892907177325655 1.0203521318288943e-10 9.991249923808034 -0.7301860042247643 MFIGGLSWDTSKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MFIGGLSWDTSKK 13 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 100023000.0 14597000.0 43428000.0 41998000.0 False True 18896104.249886822 41011193.62371987 34354794.93587045 1.0 2.1703517868750914 1.8180887701271133 24.171585493435824 -10.08992468645733 4.490655904629494 0.9999384998301619 1.994220278157923 0.9139496927019002 0.1438107750072952 32881397.78269667 4.5578125802699905 27676.70427475968 0.051187180012936304 8.129714860742224e-11 10.08992468645733 0.9942817783277611 MFIGGLSWDTTK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MFIGGLSWDTTK 12 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 278305200.0 77133300.0 95738000.0 105433900.0 False True 101122503.25993977 81454263.58380118 94524611.42138343 1.0 0.805500862398743 0.9347534759736299 26.591528841690167 -10.162909844925524 4.3561480533559935 1.0000290331583404 0.8701271691804898 0.5737716073495998 0.052767158550249195 55877187.751244664 0.7160852825884275 16427.890707057704 0.019310802701210376 6.872110831716762e-11 10.162909844925524 -0.12990186397785053 MFIGGLSWDTTK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MFIGGLSWDTTK 12 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 253583900.0 97124000.0 42571000.0 113888900.0 False True 94040851.7829897 59569822.30483229 84057980.49623626 1.0 0.6334462223108809 0.8938453757331964 26.486784270594324 -10.125346038154417 5.75439340899736 1.0000021900817826 0.7636457990220227 0.5234612124066238 0.1063075092229543 2.9869690611473798e-06 4.5406740379217903e-07 0.10293275637665618 0.03431060106643285 7.492969448790807e-11 10.125346038154417 -0.23635639105975992 MFIGGLSWDTTK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MFIGGLSWDTTK 12 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 233631100.0 66224100.0 86860700.0 80546300.0 False True 100466801.33022049 71359729.43925333 64626288.500302635 1.0 0.7102816900152297 0.6432601381214971 26.582143609072382 -13.999999999999993 0.2056690486958669 2.646437891219904 0.6020863731113495 0.9994880411172702 0.0035027781481434925 12.648720539867437 0.14377049723402202 8.3983080114096 0.04093989428629921 1.0000000000000164e-14 13.999999999999993 -2.044351518108554 MFIGGLSWDTTK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MFIGGLSWDTTK 12 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 240453400.0 77133300.0 71775100.0 91545000.0 False True 105651565.45905559 68603838.75348446 69923956.42845671 1.0 0.6493404849743691 0.6618354978900447 26.654738903213058 -9.936835208139495 5.601049398404854 1.0000003821551713 0.6555879914391023 0.9990138336717781 0.00510106766414227 2.4338133344175674e-08 4.625312194139659e-09 0.0049390929730479954 0.0016463625089685686 1.1565510090786305e-10 9.936835208139495 -0.344412390716069 MFIGGLSWDTTK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MFIGGLSWDTTK 12 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 206198300.0 97124000.0 59348300.0 49726000.0 False True 80762909.32273796 59028578.928184755 60123476.69295326 1.0 0.7308872280999648 0.7444441662284956 26.2671895460286 -10.084096337109344 7.402782430578441 1.0000000435130485 0.7376656971670231 0.9980010322425059 0.005534596814897136 3.971237259571275e-09 4.961976770934425e-10 0.005358851201398442 0.0017862834410057665 8.239553213516127e-11 10.084096337109344 -0.26233434634602537 MFIGGLSWDTTK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MFIGGLSWDTTK 12 0 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 252290300.0 66224100.0 113173000.0 72893200.0 False True 85728402.92217092 106874823.06293763 59627385.54739253 1.0 1.2466676086333326 0.6955382757045601 26.35326993116483 -6.7850132601112705 1.516025918906266 1.138760572055449 0.6904415607068786 0.7848224616913452 0.10456127644667133 0.24286399948138276 1.1026956793470304 0.05430292995627997 0.12762281830506048 1.6405396826003187e-07 6.7850132601112705 -0.44831901134857044 MFIGGLSWDTTK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MFIGGLSWDTTKK 13 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 10316200.0 3082100.0 3225300.0 4008800.0 True False 4221635.660620708 3082795.581359181 3062004.0038276007 1.0 0.7302372419570468 0.7253122367687679 22.009370644622987 MFIGGLSWDTTK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MFIGGLSWDTTKK 13 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 24711800.0 11947000.0 9956600.0 2808200.0 True False 9934459.841838786 9902961.81956964 3395381.6363502294 1.0 0.99682941772672 0.3417781832536727 23.244010096468394 -6.907961528947367 0.9094973953799892 1.021612660153456 0.2607117496135058 0.9901293692364227 0.03075353351698332 0.10578198928534198 0.1461911057375131 0.024927201163279195 0.06787683649244225 1.236056922067519e-07 6.907961528947367 -0.7609009105399502 down MFIGGLSWDTTKK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MFIGGLSWDTTKK 13 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 110840400.0 37542300.0 23481900.0 49816200.0 False True 49218318.860150374 19978492.05172928 44661697.49473291 1.0 0.40591577515063954 0.9074202152583734 25.552692045015633 -10.21350054006145 7.86245251889476 1.0000002248534885 0.6566679952045151 0.3845814502439291 0.20473833033401911 8.070731328041196e-07 8.077666200964196e-08 0.1982371658995634 0.06607901197616407 6.116450423506771e-11 10.21350054006145 -0.34333222964897336 MFIGGLSWDTTKK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MFIGGLSWDTTKK 13 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 78105410.0 33741430.0 11578980.0 32785000.0 False True 32670326.773775026 16202527.097582992 24197624.971082408 1.0 0.4959401603105179 0.7406606349130923 24.961477549123632 -10.08706561343251 5.18343577087077 1.0000070726945032 0.6183003976111272 0.7643569310340231 0.09990671540037478 138909295.1549161 12.074152250441507 11726.00478191097 0.03420072604403432 8.183411433962657e-11 10.08706561343251 -0.38170667508337597 MFIGGLSWDTTKK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MFIGGLSWDTTKK 13 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 184375700.0 37022000.0 42707000.0 104646700.0 False True 56165080.67074406 35085602.17868603 83963233.87672193 1.0 0.6246871144789762 1.4949365846893141 25.743170111373754 -6.789497382184158 1.4983026542396773 0.7901016360109999 1.5040696141687864 0.7997074923990789 0.15950116916201978 0.23609919907414403 1.047080711063408 0.08379401827237808 0.19625758404491633 1.6236881376289412e-07 6.789497382184158 0.7139679781577865 MFIGGLSWDTTKK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MFIGGLSWDTTKK 13 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 128390500.0 37542300.0 51713400.0 39134800.0 False True 51422702.8525099 49428530.99465475 29891966.24650573 1.0 0.9612200108661185 0.5812990097436453 25.615902106538524 -6.926533536988991 0.7747215602668899 1.0065803014670454 0.5097701567552191 0.9958118731751825 0.012224906041285113 0.09447832584981185 0.08679530760969434 0.010915806862433887 0.03505439684765086 1.1843129087257978e-07 6.926533536988991 -0.4968101447118263 MFIGGLSWDTTKK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MFIGGLSWDTTKK 13 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 55866930.0 33741430.0 11995500.0 10130000.0 False True 28057494.04379467 11930877.860579679 12248136.164172005 1.0 0.4252296317681432 0.4365370672467758 24.74188282455791 -9.991307484130932 5.300649447376511 1.0000024070643507 0.4308833495223496 0.999704022268991 0.004616241211012081 12714889.68948999 0.0023655829252056016 397.4882879306724 0.0015802621502199615 1.0202169058273858e-10 9.991307484130932 -0.5691190575420011 MFIGGLSWDTTKK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MFIGGLSWDTTKK 13 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;D6RD83;Q14103-4;Q14103-2;D6RBQ9;D6RF44 Q14103-3;Q14103-4;D6RF44 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 309159000.0 37022000.0 132836100.0 139300900.0 False True 47925708.812722415 125443654.26268363 113949565.54793574 1.0 2.6174605941223597 2.3776292176128764 25.514296433466203 -10.645209936378366 6.6295407612163535 0.9933429064212815 2.497544905867617 0.9811270919131981 0.09791074945959162 0.009577507523237055 0.0005125540202064585 0.09424713887895421 0.03160055850597377 2.2635498512928337e-11 10.645209936378366 1.5042019994463354 MFIGGLSWQTSPDSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MFIGGLSWQTSPDSLR 16 0 Q96DH6;B4DHE8;Q96DH6-2;J3QKT5;J3KTC1 Q96DH6 MSI2 RNA-binding protein Musashi homolog 2 0 5934000.0 1189100.0 2907600.0 1837300.0 False True 1558921.6152607796 2473797.4137360305 1647193.8206260763 1.0 1.5868645283503933 1.0566238895536324 20.572116958477544 -10.16253154741739 3.9446474298747285 0.9998525413134436 1.3217442084932691 0.329274961133329 0.21646983483076568 21335511.753729142 9161082.004996154 28170.300658808806 0.07410338268628244 6.878099475578745e-11 10.16253154741739 0.32189166717982554 MFIGGLSWQTSPDSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MFIGGLSWQTSPDSLR 16 0 Q96DH6;B4DHE8;Q96DH6-2;J3QKT5;J3KTC1 Q96DH6 MSI2 RNA-binding protein Musashi homolog 2 0 14170700.0 5687600.0 2737600.0 5745500.0 False True 5507050.251234842 3830737.956395405 4240581.188694644 1.0 0.6956061378841497 0.7700276909119871 22.392848342308433 -10.7176642194841 6.483334631107711 1.0039475861547196 0.7328169143980718 0.9450107779123866 0.030382471797280337 0.0017531589919334545 7.634633384547349e-05 0.02974918349916812 0.009805900607290271 1.9157365295783908e-11 10.7176642194841 -0.27113067175664773 MFIGGLSWQTSPDSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MFIGGLSWQTSPDSLR 16 0 Q96DH6;B4DHE8;Q96DH6-2;J3QKT5;J3KTC1 Q96DH6 MSI2 RNA-binding protein Musashi homolog 2 0 7412900.0 1189100.0 3285800.0 2938000.0 False True 1628742.404219227 3140622.491312437 2244104.910009351 1.0 1.928249969532759 1.377814505348445 20.635327020000435 -10.556547200521742 5.390930120181733 0.9973434893130265 1.6530322374406032 0.652379624267466 0.22471433726393358 0.007196082608964128 0.0005919421537159214 0.21822512169383756 0.07252624048977027 2.7762131019354823e-11 10.556547200521742 0.6556887481275767 MFK(ub)AFVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MFKAFVSK 8 1 Q92995;Q92995-2;H7C5J3 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 8990000.0 2973000.0 2589500.0 3427500.0 True False 2878623.7423379226 3623500.854064107 2529734.927204053 1.0 1.2587615396797984 0.8788001328542806 21.456947799511635 -6.72332342563201 1.7471837101224759 1.1568636134554788 0.8792713342816676 0.5282383214219771 0.10884568499940839 0.3488960915122309 2.0831587577813875 0.04942991744162345 0.12361328095355036 1.8909348865104028e-07 6.72332342563201 -0.27759227917381124 MFK(ub)AFVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MFKAFVSK 8 1 Q92995;Q92995-2;H7C5J3 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 8941900.0 2973000.0 4135700.0 1833200.0 True False 2472181.2262314153 4113420.163227823 2216513.6442408804 1.0 1.663882938508641 0.8965821844783306 21.23735307494591 -6.67787092095258 1.9095779665027608 1.4208487305061972 0.8995575073968943 0.314365058176434 0.281501536874517 0.44326195774234095 3.1232117686659353 0.1183719834421102 0.3130378772439272 2.0995638137866302e-07 6.67787092095258 -0.5212912231093029 MFK(ub)MSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MFKMSEK 7 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 8953300.0 3655300.0 2597700.0 2700300.0 True False 4792133.697975548 2210133.28575529 2420898.8591066212 1.0 0.4612002554705366 0.505181827487271 22.192236728434924 -9.875043975368715 6.897604390115668 1.0000000089913574 0.483191042898122 0.994597557831643 0.01795540158776975 2.479097743141045e-09 4.1313813062914285e-10 0.017385242960493503 0.00579508094365457 1.333386410581769e-10 9.875043975368715 -0.5168089660932355 MFK(ub)MSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MFKMSEK 7 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 15328200.0 3867700.0 3800000.0 7660500.0 True False 3744921.9805719405 5317359.816738213 5653985.239926088 1.0 1.419885339220371 1.5097738402183178 21.836504232089794 -12.036410644630257 0.25199944550993775 4.130426797984798e-11 1.5486271346564922 0.9993834841085615 0.005516528094691058 5.281418038398406 0.14678631523375057 2.7894728378695777 0.040950067288152446 9.195796573314724e-13 12.036410644630257 1.5486271346151879 MFK(ub)MSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MFKMSEK 7 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 63853700.0 4749700.0 20216000.0 38888000.0 True False 7205642.149582237 16608296.851671055 31201769.754784096 1.0 2.304901701596985 4.330185860894173 22.78069557498251 -6.964684001339049 0.36343458831275144 0.8321876402350475 5.872676169681511 0.9999064829669243 0.013249487446361232 0.07806835115493195 0.015239022433108953 0.02699179341670167 0.17263606996063402 1.0847158812055616e-07 6.964684001339049 5.040488529446463 MFK(ub)MSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MFKMSEK 7 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 10764500.0 3655300.0 2561300.0 4547900.0 True False 5006763.190768259 2448133.2969135502 3473779.686940617 1.0 0.48896526630769177 0.693817453428946 22.255446789957816 -10.199108869536818 5.432142348729988 1.0000182285833814 0.5913913598682656 0.8413917929193946 0.08363055519022436 1.8463371403983068e-05 2.722175938781014e-06 0.08097854529648671 0.026991645623790896 6.322533373743777e-11 10.199108869536818 -0.4086268687151158 MFK(ub)MSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MFKMSEK 7 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 16870000.0 3867700.0 7863900.0 5138400.0 True False 3216163.9181618704 7821535.60983806 6212815.682722742 1.0 2.4319455751833354 1.931747212148796 21.61690950752407 -9.72706407061081 6.4081454269769536 0.9999999918231061 2.181846393667219 0.8815654802380531 0.204205126605806 2.4231517425129552e-08 4.597693733792796e-09 0.19772076510992084 0.06590692121226313 1.874717914218276e-10 9.72706407061081 1.1818464018441128 MFK(ub)MSEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MFKMSEK 7 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 51559700.0 4749700.0 14082000.0 32728000.0 True False 6148580.280584196 13298324.320927141 26771839.817638174 1.0 2.162828443977579 4.354149835560819 22.55182189707496 -6.961191626398099 0.41830149742763467 0.9013502872943758 5.698060282136412 0.9998118717866038 0.019073701261547043 0.07927817152038023 0.01957860929311217 0.02831744384128999 0.18249774969504223 1.0934737797200702e-07 6.961191626398099 4.796709994842036 MFK(ub)QFNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MFKQFNK 7 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 8294800.0 1439100.0 3501300.0 3354400.0 True False 1886674.0362642254 2978919.687960506 3007318.8656768715 1.0 1.5789265292795462 1.5939790381764187 20.847413757028242 -11.38449099684526 0.5917800480396794 6.910822461512179e-11 1.5922201874191402 0.9999415093329175 0.002114831301060807 4.100322523116794 0.29354471475552735 5.332061852816424 0.0026475680201312507 4.1258079004646806e-12 11.38449099684526 1.592220187350032 MFK(ub)QFNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MFKQFNK 7 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 15512900.0 4365100.0 4621100.0 6526700.0 True False 4226532.289834943 6466329.328718139 4817161.473196995 1.0 1.5299372831647446 1.1397432085832044 22.011043041174986 -10.577294863944491 10.501773700797914 0.9999878189711685 1.3348402458739745 0.49542529425009907 0.15929606389704284 4.54328360972657e-05 1.8287407389453448e-06 0.1542433476617525 0.05141258354913664 2.6467025515348196e-11 10.577294863944491 0.33485242690280603 MFK(ub)QFNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MFKQFNK 7 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 34618700.0 7431000.0 6546700.0 20641000.0 True False 11273370.27886931 5378390.235399433 16561297.3027283 1.0 0.4770880493015148 1.4690635447121458 23.426415551303403 -6.763518117522938 1.5996417090184796 0.6975906584356721 1.4732784325248736 0.7050121543481072 0.22005972617606856 0.27704496985412846 1.398012407242412 0.10851242383100881 0.2598314627449807 1.7237801783509803e-07 6.763518117522938 0.7756877740892014 MFK(ub)QFNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MFKQFNK 7 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 19505900.0 4365100.0 11632000.0 3508800.0 True False 3629774.056718051 11569336.107228773 4242473.8571418235 1.0 3.1873433239779865 1.1687983303781062 21.791448316609262 -6.627121939642406 2.0907473870002486 2.4440720270210723 1.1768153435903637 0.10722950392002817 0.9389406974331136 0.5665865127220968 4.715772454604725 0.3677762616213563 1.0404306171405853 2.3598155596291606e-07 6.627121939642406 -1.2672566834307086 MFK(ub)QFNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MFKQFNK 7 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 28548800.0 7431000.0 7609800.0 13508000.0 True False 9619575.986908885 7186307.940448179 11049682.603784429 1.0 0.7470503845728649 1.148666284129545 23.197541873395853 -6.736460288897267 1.6994585988407778 0.8488795740905684 1.1487320774255958 0.5889653849388452 0.1062920241327955 0.32429304041654833 1.8375801916207182 0.04950519147405147 0.12196577997439793 1.8345929113095283e-07 6.736460288897267 0.29985250333502744 MFLQYYLNEQGDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MFLQYYLNEQGDR 13 0 Q9NPE3;H0YM60 Q9NPE3 NOP10 H/ACA ribonucleoprotein complex subunit 3 0 15030300.0 3231200.0 6746900.0 5052200.0 False True 4901966.6323620705 5542862.9812297 4053630.455542078 1.0 1.1307426991927128 0.8269396263900695 22.22492923315161 -6.789723024631049 1.4971965998841237 1.0730961936365748 0.823721418550791 0.8005278777162435 0.055572191313421705 0.23574737668954496 1.04394094409856 0.02921497785912984 0.06842039485151306 1.6228447518168576e-07 6.789723024631049 -0.24937477508578387 MFLYNLTLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MFLYNLTLQR 10 0 Q15393;Q15393-2;I3L4G7;H3BMB0 Q15393 SF3B3 Splicing factor 3B subunit 3 0 17194800.0 5710900.0 7867900.0 3616000.0 False True 7487045.204434277 6694039.988833997 3241851.0071212593 1.0 0.8940830202106147 0.43299471535195766 22.835965034339452 -6.942935351774326 0.6316675396224327 1.0050303585128262 0.2971261936311906 0.9985236265490844 0.009458033069004078 0.0864527221554774 0.04870091633506953 0.009426048228377044 0.03920072108750658 1.1404195355443443e-07 6.942935351774326 -0.7079041648816355 down MFLYNLTLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MFLYNLTLQR 10 0 Q15393;Q15393-2;I3L4G7;H3BMB0 Q15393 SF3B3 Splicing factor 3B subunit 3 0 22305100.0 12966000.0 4491000.0 4848100.0 False True 12554401.42722956 6284279.720255614 3578237.1701175678 1.0 0.5005638665197912 0.2850185403787263 23.581689909184654 -11.81240961315626 0.14438531102021165 2.3093417400092866 8.909825535228941e-14 0.9996425418713181 0.005661784865455581 4.963477951053369 0.09604806493964779 2.2096199744569427 0.21771934516720712 1.5402470541558428e-12 11.81240961315626 -2.3093417400091973 MFLYNLTLQR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MFLYNLTLQR 10 0 Q15393;Q15393-2;I3L4G7;H3BMB0 Q15393 SF3B3 Splicing factor 3B subunit 3 0 104201600.0 30938500.0 35375600.0 37887500.0 False True 46935966.40732037 29062547.789175626 30399019.018318824 1.0 0.6191956832626947 0.6476700352669768 25.484190528778278 -9.902439769059315 5.177952536597319 1.0000007603941148 0.6334328592587852 0.995494934995036 0.011624605548917042 3406841.7313011605 6515325.211845287 18.357800651904014 0.003979411584281343 1.2518728793194518e-10 9.902439769059315 -0.36656790113532955 MFLYNLTLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MFLYNLTLQR 10 0 Q15393;Q15393-2;I3L4G7;H3BMB0 Q15393 SF3B3 Splicing factor 3B subunit 3 0 25643600.0 5710900.0 8083700.0 11849000.0 False True 7822374.061269527 7726535.404778849 9050510.237815104 1.0 0.987748136852059 1.1570029976738618 22.899175095862343 -6.889493632100871 1.0253342670077785 0.9907950765862983 1.1714190049979931 0.9805736075422243 0.010740820901410406 0.11955653468615063 0.2242357901424339 0.007986724677732213 0.019875824767403592 1.289752468922845e-07 6.889493632100871 0.18062392841169483 MFLYNLTLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MFLYNLTLQR 10 0 Q15393;Q15393-2;I3L4G7;H3BMB0 Q15393 SF3B3 Splicing factor 3B subunit 3 0 24502000.0 12966000.0 5435400.0 6100600.0 False True 10781803.491192909 5406118.421357573 7376207.2540126145 1.0 0.501411329354458 0.6841348258700738 23.36209518461893 -10.249700343143905 5.021161416940185 1.0000695762127894 0.5927730776120236 0.8688096916566004 0.07459655508092065 5.81111319360672e-05 8.683429792031274e-06 0.07224009698434052 0.024075934625950417 5.627294663905741e-11 10.249700343143905 -0.4072964986007658 MFLYNLTLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MFLYNLTLQR 10 0 Q15393;Q15393-2;I3L4G7;H3BMB0 Q15393 SF3B3 Splicing factor 3B subunit 3 0 111590000.0 30938500.0 47077600.0 33573900.0 False True 40050498.13900957 44457690.175463706 27463794.69730518 1.0 1.1100408794207102 0.685729166263607 25.255316850870727 -6.837859541244408 1.29244289144748 1.0585632804203997 0.672366612438565 0.9206854279779816 0.05063359074427414 0.17131588081329596 0.5568293479102365 0.030731288752683657 0.07075793828038435 1.4525813329199057e-07 6.837859541244408 -0.3861966679818347 MFNGEK(ub)INYTEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MFNGEKINYTEGR 13 1 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ELR7;A0A2R8YF08;K7ERK8 P06744 GPI Glucose-6-phosphate isomerase 1 6116120.0 1084600.0 985020.0 4046500.0 True False 1050169.966680023 1378343.6228114418 2986600.2576020993 1.0 1.3124957545385703 2.8439208436362464 20.002191411731836 -6.940253976761653 0.657195457054568 0.9828824287247359 3.2600027800405504 0.9981969904542154 0.03421324177941379 0.08765093515253666 0.05408323605983802 0.033368478369244295 0.1316598684320095 1.1474823739865578e-07 6.940253976761653 2.2771203513158147 up MFNGEK(ub)INYTEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MFNGEKINYTEGR 13 1 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ELR7;A0A2R8YF08;K7ERK8 P06744 GPI Glucose-6-phosphate isomerase 1 4754100.0 1084600.0 1919400.0 1750100.0 True False 901892.9559268721 1909059.8112289282 2116037.8184518665 1.0 2.116725492402803 2.346218367208803 19.782596687166112 -10.555348893445995 0.3267685205143182 2.021907298066629e-24 2.40111898035189 0.9991258092881015 0.017386207873327116 2.115661717368736 0.15786605597938932 1.8073804480085636 0.07398364270563135 2.7838838179260087e-11 10.555348893445995 2.40111898035189 MFNGEK(ub)INYTEGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MFNGEKINYTEGR 13 1 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ELR7;A0A2R8YF08;K7ERK8 P06744 GPI Glucose-6-phosphate isomerase 1 11328200.0 2480800.0 3464600.0 5382800.0 True False 3211444.5038788253 3271791.9643718298 4403185.632192095 1.0 1.0187913757874738 1.3710919266622446 21.614790935153593 -6.917931500742566 0.839930442742188 0.991632208842799 1.425284901073674 0.9935866764466804 0.01366842314463449 0.09940413020421944 0.11203538469607231 0.011649533539563717 0.03423449106679122 1.2080043530140234e-07 6.917931500742566 0.4336526922308749 MFQIQFHTGFVPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MFQIQFHTGFVPR 13 0 O14976-2;O14976 O14976-2 GAK Cyclin-G-associated kinase 0 55008000.0 20439000.0 16596000.0 17973000.0 False True 31007457.29105229 13634314.134860165 14420628.672154246 1.0 0.4397108091412117 0.4650696939382887 24.886111889485083 -10.447939750182291 6.036605272762638 1.0002546251839972 0.4523902515397543 0.9983942370841447 0.010352721366477087 3.549335118213462e-05 3.24593086989119e-06 0.010028513652669095 0.003341326453357567 3.5650058744067265e-11 10.447939750182291 -0.5478643736442429 MFQIQFHTGFVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MFQIQFHTGFVPR 13 0 O14976-2;O14976 O14976-2 GAK Cyclin-G-associated kinase 0 4842600.0 2069000.0 1205800.0 1567800.0 False True 1720465.1722411043 1199304.1160674382 1895619.731311831 1.0 0.6970813099954858 1.1018065125041547 20.714367256898278 -6.7063897939330595 1.8082059693180967 0.8130888052153954 1.1007531206451853 0.44790150283101315 0.12772269442315934 0.38236797910699094 2.434747777301199 0.056261122587995066 0.1435518359777127 1.9661208378396364e-07 6.7063897939330595 0.2876643154297899 MFQIQFHTGFVPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MFQIQFHTGFVPR 13 0 O14976-2;O14976 O14976-2 GAK Cyclin-G-associated kinase 0 48903000.0 20439000.0 17321000.0 11143000.0 False True 26458688.412922952 16357071.12361731 9115088.3368352 1.0 0.6182117143655613 0.34450265238329836 24.657238211577532 -7.996400082971562 0.20433484030416296 1.2428762890985896 2.6999460029820464e-18 0.9998281855609694 0.003523574620834375 0.10371267458160746 0.035686853403862545 0.07723427743230737 0.10227938040567408 1.0083235651222427e-08 7.996400082971562 -1.2428762890985896 down MFVGGLSWDTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MFVGGLSWDTSK 12 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 58743000.0 19078000.0 20133000.0 19532000.0 False True 25011442.75161478 17129234.877819348 17511016.0041738 1.0 0.6848559296609732 0.7001201881104304 24.57608494406412 -10.193301261592662 8.002443355036455 1.0000001077211735 0.6924880588897511 0.9981554634023925 0.006231607417189489 1.1978185699392807e-08 1.2021739281393746e-09 0.0060337300046155945 0.0020112426455731218 6.407649362729976e-11 10.193301261592662 -0.30751204883142247 MFVGGLSWDTSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MFVGGLSWDTSK 12 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 50087000.0 17966000.0 10349000.0 21772000.0 False True 17395679.164091203 14481409.669322034 16069260.054000482 1.0 0.8324716461323964 0.9237500819842226 24.052225670133343 -10.130063584117513 4.405171169104212 1.0000140149875012 0.8781108640640242 0.7039286901920774 0.0372642654820851 52032718.46102727 0.3401213440060723 9466.471694099902 0.012756549231834238 7.412017156135754e-11 10.130063584117513 -0.12190315092347703 MFVGGLSWDTSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MFVGGLSWDTSK 12 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 30340000.0 15429000.0 0.0 14911000.0 False True 23406921.010991063 0.0 11963834.314276543 1.0 0.0 0.5111237957636012 24.480431836409497 -9.690061892012716 11.430203981482471 1.0000000000286489 0.2555618890676348 0.7387955600995906 0.20866541583589102 0.0 0.0 0.20203942011546297 0.06734647337182098 2.0414469940078817e-10 9.690061892012716 -0.7444381109610141 MFVGGLSWDTSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MFVGGLSWDTSK 12 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 39103000.0 17966000.0 10654000.0 10483000.0 False True 14939525.028749961 10596604.787346587 12674946.832084415 1.0 0.709299978878461 0.8484169883374779 23.83263094556762 -10.07948142102308 4.723286104791361 1.0000099245216343 0.7788584836039936 0.7711219138739412 0.05679428129969153 5.937051777078528e-06 1.1569997235921078e-06 0.05499329476385638 0.018330275467532648 8.32757550320841e-11 10.07948142102308 -0.22115144091764072 MFVGGLSWDTSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MFVGGLSWDTSK 12 0 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 66450000.0 15429000.0 28893000.0 22128000.0 False True 19973144.651058696 27285079.151011758 18100931.05245348 1.0 1.3660882964448708 0.9062634536867494 24.251558158501947 -6.69461127159422 1.8498672359619512 1.228518913123551 0.907753459970103 0.39206878587590044 0.15468866274893936 0.40688475130463153 2.702943173354374 0.06680583113740791 0.17297309587386692 2.0201737722825626e-07 6.69461127159422 -0.32076545315344795 MFVGGLSWDTSKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MFVGGLSWDTSKK 13 1 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 33676200.0 12292200.0 3318400.0 18065600.0 False True 16115193.237834139 2823307.65502189 16196345.009471765 1.0 0.17519539563407302 1.005035730595343 23.94191815211837 -10.98215848143882 12.76852725878492 1.2425780567027962 0.590115563114708 0.24544893407839452 0.33878089810589795 0.07235089282875051 0.00010109614863116872 0.010144616179067275 0.10934106469811118 1.0419371394367965e-11 10.98215848143882 -0.6524624935880882 MFVGGLSWDTSKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MFVGGLSWDTSKK 13 1 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 23606000.0 10238000.0 3011800.0 10356200.0 False True 9913000.293997858 4214427.4463295145 7643600.54065955 1.0 0.42514146286077226 0.7710683258314449 23.24089034259537 -10.344360257547793 6.18498347656166 1.000035399061133 0.5981048943461308 0.6428164821629884 0.1412240504333046 6.894130815526444e-05 7.307927422042918e-06 0.13675160852845789 0.045579866284345356 4.525220464243893e-11 10.344360257547793 -0.40193050471500225 MFVGGLSWDTSKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MFVGGLSWDTSKK 13 1 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 97276300.0 17804300.0 32822000.0 46650000.0 False True 27010424.76868158 26964657.660543498 37429607.05257868 1.0 0.9983055761421735 1.3857467023613075 24.687012992205467 -6.905914345578894 0.9231008157853641 0.9863994362153004 1.4316776708304189 0.989286353542248 0.018863423717542058 0.10718271618128082 0.1538785229923153 0.015138275613231857 0.04069553349218261 1.24189721859765e-07 6.905914345578894 0.4452782346151185 MFVGGLSWDTSKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MFVGGLSWDTSKK 13 1 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 31134800.0 12292200.0 12267100.0 6575500.0 False True 16836958.524214618 11725098.960125022 5022502.3266734155 1.0 0.69639055909428 0.298302233117112 24.00512821364126 -7.133149572874804 0.34353357615134145 1.0465990360434652 2.77536649400833e-15 0.9998977544988955 0.002905386899388727 0.08000807475921722 0.01663160341012965 0.00727253335485177 0.03669103566449916 7.359535882827336e-08 7.133149572874804 -1.0465990360434625 down MFVGGLSWDTSKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MFVGGLSWDTSKK 13 1 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 12987900.0 10238000.0 1114700.0 1635200.0 False True 8513350.620301787 1108694.889849373 1977112.7596894414 1.0 0.130230145485312 0.23223673590684973 23.021295618029647 -10.533399439758698 6.27315209250107 1.0009685093454574 0.18123344069608113 0.9884927635798999 0.041644016155640284 0.0005646405494596638 4.199820514627075e-05 0.04036140201224877 0.013440548419998952 2.9281988129578785e-11 10.533399439758698 -0.8197350686493763 MFVGGLSWDTSKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MFVGGLSWDTSKK 13 1 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 88796500.0 17804300.0 40516200.0 30476000.0 False True 23048017.325221613 38261437.85339779 24929680.710166864 1.0 1.6600750213567401 1.0816410087858679 24.458139314297917 -10.32415137122954 4.176960463546594 0.9994425387711496 1.3708580150801928 0.3540398550783479 0.23614469680792075 0.0012277062500949348 0.00019864701504373878 0.22898308525733221 0.07621537316524983 4.7407671932568024e-11 10.32415137122954 0.37141547630904315 MFVGGLSWDTSKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 MFVGGLSWDTSKK 13 1 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 1 40179200.0 17292000.0 16131000.0 6756200.0 True False 26233228.214534774 13252297.017921757 5420834.108652344 1.0 0.5051721774211225 0.20663999353495038 24.644892018231786 -8.543053396499273 0.26072351062714477 1.227892634515735 3.2154191451817613e-22 0.9992254918798197 0.009105296581809384 0.18404833025880735 0.0709497985529005 0.13852133739256056 0.10760943858658083 2.863825840920743e-09 8.543053396499273 -1.227892634515735 down MFVGGLSWDTSKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MFVGGLSWDTSKK 13 1 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 1 21329400.0 9597800.0 9716200.0 2015400.0 True False 7980995.954633002 9663856.90208531 2436810.8218432623 1.0 1.2108585140273627 0.3053266579378083 22.928137362031556 -6.8453747546663575 1.2571217214563206 1.112228296016952 0.2722172558209565 0.9333053411497635 0.0999105486551957 0.16262563003373903 0.4968875346228144 0.062254643495109584 0.14370523965722878 1.4276614912996745e-07 6.8453747546663575 -0.8400110401959955 down MFVLDEADEMLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MFVLDEADEMLSR 13 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;Q14240-2;Q14240;E7EQG2;J3KTN0 P60842;Q14240-2;J3KTN0 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 13618800.0 7700100.0 2075800.0 3842900.0 False True 7455664.54032165 2904677.7651539976 2836329.205471177 1.0 0.38959340907104234 0.3804260760569055 22.829905518251188 MFYAHFVLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MFYAHFVLSK 10 0 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7 O60216 RAD21 Double-strand-break repair protein rad21 homolog 0 113673000.0 29709000.0 32962000.0 51002000.0 False True 45070725.01883039 27079673.566718493 40921432.34502928 1.0 0.6008262249032981 0.9079381866595767 25.425687322000734 -9.940957643517853 6.002268085876982 1.0000001080447545 0.7543822057813744 0.460286482223344 0.12537793336822844 1.8124179463148693e-07 3.209677953137048e-08 0.12139671534296578 0.040465553993054806 1.1456246680886555e-10 9.940957643517853 -0.2456179022633801 MFYAHFVLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MFYAHFVLSK 10 0 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7 O60216 RAD21 Double-strand-break repair protein rad21 homolog 0 113170000.0 29709000.0 48394000.0 35067000.0 False True 38458886.15194136 45700831.358255014 28685165.81780489 1.0 1.1883035607870325 0.745865746201724 25.196813644093183 -6.7910489710496265 1.492001476326617 1.1050988127967534 0.7410139306216222 0.8047522554854551 0.0801062118660529 0.23378753219338555 1.028074116568518 0.04225694399522313 0.09886468425297482 1.6178975932100992e-07 6.7910489710496265 -0.36408488217513113 MFYHISLEHEILLHPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MFYHISLEHEILLHPR 16 0 P62487;E9PIU7;E9PKH3 P62487 POLR2G DNA-directed RNA polymerase II subunit RPB7 0 29198500.0 3125800.0 14533000.0 11539700.0 False True 4046409.7187296194 13724225.774466258 9439593.007320935 1.0 3.3917044314471974 2.332831735656398 21.94821097652945 -10.581953407539244 6.79183370038917 0.997303881550793 2.8622680835517817 0.8048461102408597 0.43228296787545584 0.0176421019263981 0.0010858940269064669 0.41841551996188664 0.13951872795256304 2.6184639100908364e-11 10.581953407539244 1.864964202000989 MGAGIAVLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MGAGIAVLFK 10 0 C9JXC3;C9JNE2;Q9Y530;H7C5Q1;C9JA90;C9J5P1;C9IZY1 C9JXC3 OARD1 O-acetyl-ADP-ribose deacetylase 1 0 2511610.0 719330.0 1011300.0 780980.0 False True 943048.5960016288 860417.982016524 700171.6812891503 1.0 0.9123792619643939 0.7424555683108625 19.8469725904105 -6.9606431624282985 0.42627437177148364 1.0070224915374724 0.641335967639107 0.9997933071055669 0.001537110815299838 0.07947219022729855 0.020288450533801614 0.002208339625164663 0.014121559017142864 1.0948555836576801e-07 6.9606431624282985 -0.3656865238983653 MGAGIAVLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MGAGIAVLFK 10 0 C9JXC3;C9JNE2;Q9Y530;H7C5Q1;C9JA90;C9J5P1;C9IZY1 C9JXC3 OARD1 O-acetyl-ADP-ribose deacetylase 1 0 1741630.0 719330.0 0.0 1022300.0 False True 985285.7401623217 0.0 780853.7949293937 1.0 0.0 0.7925150675587279 19.91018265193339 -10.738823685196696 10.293995728082297 1.0012368124708095 0.396257533782244 0.4362376801407861 0.3235429214977036 0.009194697172041112 0.00023328484747401037 0.313641188972696 0.10442302889532498 1.8246363175282098e-11 10.738823685196696 -0.6049792786885655 MGAGLGHGMDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MGAGLGHGMDR 11 0 P52272-2;P52272;A0A087X0X3;M0R2T0;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 3942620.0 395820.0 1627100.0 1919700.0 False True 518923.8531263326 1384343.022386124 1721067.859062692 1.0 2.667718999706695 3.316609650325124 18.985163327515515 -9.504313965693228 0.2777531496659662 7.705931168060619e-11 3.628493262452708 0.9988781597998891 0.032682101038511956 0.8943673912404321 0.11155714621045544 1.055909606388894 0.24961543152976243 3.131021388108884e-10 9.504313965693228 3.628493262375649 MGAGLGHGMDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MGAGLGHGMDR 11 0 P52272-2;P52272;A0A087X0X3;M0R2T0;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 3535820.0 395820.0 1627400.0 1512600.0 False True 542165.350633298 1555496.0869078652 1155355.0329748602 1.0 2.8690437061145744 2.1310012372153646 19.048373389038407 -10.429138110043217 5.830482114745828 0.9992957972362714 2.5000224716649706 0.846336263643056 0.30130457621783535 0.002759144208644703 0.0002701466990463119 0.29184752803090125 0.09724563381897937 3.722733007489515e-11 10.429138110043217 1.5007266744286993 MGAGMGFGLER ddPTM_RPMI8226_Bortezomib_1h_R1 2 MGAGMGFGLER 11 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 23370100.0 6610700.0 8245700.0 8513700.0 False True 8666691.71810986 7015473.701486858 7632783.993177073 1.0 0.8094753949569213 0.8807032996486607 23.047049956921875 -10.847486957278416 9.976600972805524 1.0046614336415536 0.845089347802299 0.8631389776950955 0.029078670323725554 0.0030705929688131907 4.6940316719082324e-05 0.028675017168329733 0.009385100491137076 1.420734879695716e-11 10.847486957278416 -0.15957208583925453 MGAGMGFGLER ddPTM_RPMI8226_Bortezomib_2h_R1 2 MGAGMGFGLER 11 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 10518350.0 2375050.0 1329100.0 6814200.0 False True 2299655.3377866386 1859816.5611649367 5029356.598381868 1.0 0.808737087947694 2.1870045113901715 21.132986221917132 -6.871809683012469 1.1245525285195364 0.8905623092287347 2.2705217730036598 0.966452481798007 0.11166545465963548 0.13512771360726453 0.31829057634261976 0.07697856206097814 0.182834498161729 1.343353517969941e-07 6.871809683012469 1.379959463774925 up MGAGMGFGLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MGAGMGFGLER 11 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 10344500.0 2891000.0 3508200.0 3945300.0 False True 3959880.8263373836 3353196.123933983 3013501.396004047 1.0 0.8467921816312483 0.761008103062366 21.9170255819929 -13.999999999999973 0.06821779802888996 1.900092220222626 0.4379233635636992 0.9999303303882243 0.0008250959374587712 12.378893504194137 0.06988545917039866 1.793236384842169 0.2984508388577277 1.0000000000000614e-14 13.999999999999973 -1.4621688566589268 MGAGMGFGLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MGAGMGFGLER 11 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 4156400.0 1750200.0 1178400.0 1227800.0 False True 1455368.847006468 1172051.7253059149 1484527.303294213 1.0 0.8053296782576423 1.0200350971835908 20.47295340377024 -6.667991978781715 1.9447141833786046 0.8755283057198591 1.0191562276723565 0.2701270923343396 0.08273022678624878 0.46571901282557726 3.3937502389717227 0.034273427950469636 0.09180299932738839 2.1478701439326835e-07 6.667991978781715 0.1436279219524974 MGANNLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 MGANNLER 8 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 6817140.0 1919700.0 845340.0 4052100.0 False True 1858760.1742906545 1182888.6703898625 2990733.4496057006 1.0 0.6363858483471543 1.6089937211760161 20.825909208499514 -6.805444180294086 1.4334697469055269 0.8007361952822601 1.6243120207893034 0.8476206578288269 0.15663332920118758 0.2130850986325885 0.8637576355312037 0.08593701223437292 0.19924305088980748 1.565149474368857e-07 6.805444180294086 0.8235758255070432 MGANSLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 MGANSLER 8 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 11475800.0 3645200.0 1315800.0 6514800.0 False True 3529485.121281599 1841205.8018063528 4808378.440189347 1.0 0.5216641347216641 1.3623455759018375 21.751026308868344 -6.752352836964391 1.640915240940543 0.719527330510205 1.3643411195825015 0.6590733871082722 0.20102951264984145 0.2959843224056459 1.5686891599265387 0.09674450306454782 0.2343127299662219 1.768671440093299e-07 6.752352836964391 0.6448137890722965 MGESDDSILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MGESDDSILR 10 0 P63220;Q8WVC2 P63220 RPS21 40S ribosomal protein S21 0 23194000.0 7192600.0 1789400.0 14212000.0 False True 6964274.85003019 2503916.751597724 10489450.849139027 1.0 0.3595373252086496 1.5061799074592175 22.731541710416415 -6.755146363247252 1.6310111882468619 0.6257421018455241 1.5093549226246896 0.6707403093878612 0.2692230004720396 0.29114681525752106 1.525323547606011 0.13031897778446103 0.3146625711451316 1.7573312692062416e-07 6.755146363247252 0.8836128207791655 MGFAVLLVNYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MGFAVLLVNYR 11 0 C9JIF9;P13798 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 6687600.0 3003200.0 2131800.0 1552600.0 False True 3937224.283030171 1813743.7496913148 1391951.8455908385 1.0 0.4606655906062378 0.35353633563378384 21.90874746693647 -13.999999999999998 0.22723010385573814 4.361593710610103 0.30005717244459773 0.9995061386555542 0.006286802444587646 13.206510609865827 0.1509540402852389 19.99891329322182 0.05658389761483313 1.0000000000000041e-14 13.999999999999998 -4.061536538165505 MGFAVLLVNYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MGFAVLLVNYR 11 0 C9JIF9;P13798 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 9012500.0 5841600.0 1816300.0 1354600.0 False True 5656161.605530181 2541558.061879373 999789.6228710755 1.0 0.44934325415922055 0.17676114874326687 22.431391910151515 -9.130184399594171 0.2495232240736516 1.3407453608302384 8.47198383376811e-21 0.9991405607069475 0.010038368780222592 0.5680128445151665 0.08834318253826322 0.2784104151623253 0.11347869007669657 7.409955509308943e-10 9.130184399594171 -1.3407453608302384 MGFAVLLVNYR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MGFAVLLVNYR 11 0 C9JIF9;P13798 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 80219400.0 21133800.0 22574800.0 36510800.0 False True 32061519.687736277 18546150.562282532 29294424.376747902 1.0 0.5784551307272109 0.9136941936022202 24.934339473796324 -10.070607574683688 7.732530103357126 1.0000000165253677 0.7460746621647155 0.4334165338883179 0.13686077431543003 3.901954611105328e-08 4.5965891875279456e-09 0.1325148847912946 0.04417162497272605 8.499481350742534e-11 10.070607574683688 -0.2539253543606522 MGFAVLLVNYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MGFAVLLVNYR 11 0 C9JIF9;P13798 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 12691400.0 3003200.0 3234400.0 6453800.0 False True 4113564.198428379 3091493.513269505 4929545.360183233 1.0 0.7515364691404683 1.1983635412974973 21.971957528459363 -6.755783947201251 1.6283918283614505 0.8549242111773658 1.1996615862872788 0.6735041860148616 0.10445055084456256 0.290057426748931 1.5148654091771283 0.0506349076245723 0.12219312646630623 1.7547532392993075e-07 6.755783947201251 0.344737375109913 MGFAVLLVNYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MGFAVLLVNYR 11 0 C9JIF9;P13798 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 10980900.0 5841600.0 1504600.0 3634700.0 False True 4857549.226758645 1496494.421160285 4394698.965045999 1.0 0.30807601761740017 0.9047152709924264 22.21179718558579 -10.487811513142425 8.764445344694852 1.0000127647377435 0.606395644305 0.36719929415551145 0.2435769552139901 6.0755808228150554e-05 3.5504644289773645e-06 0.23585000439731782 0.07861412425530782 3.252284181788612e-11 10.487811513142425 -0.39361712043274344 MGFAVLLVNYR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MGFAVLLVNYR 11 0 C9JIF9;P13798 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 70661900.0 21133800.0 23496600.0 26031500.0 False True 27358120.70947854 22188993.55482862 21294034.10574579 1.0 0.811056935907918 0.7783441827701354 24.705465795888774 -13.999999999999998 0.24670516107593424 2.2925027505553617 0.7647724128426499 0.9995366029790814 0.0021030645506072846 13.869818342391635 0.15717879797008005 8.86656169054615 0.015378436432192416 1.0000000000000041e-14 13.999999999999998 -1.5277303377127118 MGFFLSLHQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MGFFLSLHQR 10 0 A2A2Q9;Q9Y312 A2A2Q9 AAR2 Protein AAR2 homolog 0 3804840.0 841840.0 1832900.0 1130100.0 False True 1103660.3923901552 1559438.4645882424 1013168.0926846636 1.0 1.4129694925547034 0.9180071149336836 20.073864877682837 -6.685327666843418 1.883375339631512 1.260032895007659 0.9198223764754867 0.3485494590580176 0.17482621556344657 0.42675548367485316 2.931171342332415 0.07436894154529866 0.1947846434201922 2.0638224538627256e-07 6.685327666843418 -0.3402105185321722 MGFFLSLHQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MGFFLSLHQR 10 0 A2A2Q9;Q9Y312 A2A2Q9 AAR2 Protein AAR2 homolog 0 99860100.0 21547100.0 32730000.0 45583000.0 False True 32688526.004013605 26889075.779342774 36573500.070261374 1.0 0.822584529386282 1.118848248641458 24.962280988559176 -6.744506679234061 1.6700007426753436 0.8949939585630015 1.1192050848097896 0.6250694912929069 0.07453987490904156 0.30972824804054105 1.6976647515649397 0.03528530792451221 0.08616892664239477 1.8009154370413593e-07 6.744506679234061 0.22421112624678818 MGFFLSLHQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MGFFLSLHQR 10 0 A2A2Q9;Q9Y312 A2A2Q9 AAR2 Protein AAR2 homolog 0 8763240.0 841840.0 2199600.0 5721800.0 False True 1153090.9978705852 2102414.3988954984 4370428.684170014 1.0 1.8232857621627696 3.790185416624439 20.13707493920573 -6.956427224096185 0.4831686510204211 0.9541682810885178 4.7417476953461914 0.9996138566799802 0.023001873389332083 0.08100307041995 0.026042088433043377 0.02791341786841896 0.16223715613363393 1.10553571147821e-07 6.956427224096185 3.7875794142576735 MGFFLSLHQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MGFFLSLHQR 10 0 A2A2Q9;Q9Y312 A2A2Q9 AAR2 Protein AAR2 homolog 0 4539900.0 1338100.0 1731500.0 1470300.0 False True 1112689.437881014 1722172.0658241592 1777732.932100896 1.0 1.5477562805878997 1.5976901294995474 20.085619548392074 -11.55657709725977 0.3970408117543162 8.546455938292024e-25 1.601421186128696 0.9996618071049701 0.0049791469312732 4.1210305686209505 0.2000043821005924 3.5328156570977334 0.012867417813372448 2.7760219946050772e-12 11.55657709725977 1.601421186128696 MGFFLSLHQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MGFFLSLHQR 10 0 A2A2Q9;Q9Y312 A2A2Q9 AAR2 Protein AAR2 homolog 0 79498900.0 21547100.0 29688000.0 28263800.0 False True 27893145.70683953 28035836.702150613 23120078.41107804 1.0 1.0051156293668266 0.8288802795522947 24.733407310651625 -6.900213149637725 0.9598983374913668 1.0072844264827678 0.8102997492293473 0.9866726599279991 0.00945475542206129 0.11124926769636713 0.17652721935015994 0.007384249818366348 0.019233632295850803 1.258307688872205e-07 6.900213149637725 -0.1969846772534205 MGFNIGVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MGFNIGVR 8 0 O43617;A6NKE1;O43617-2 O43617 TRAPPC3 Trafficking protein particle complex subunit 3 0 60037000.0 15979000.0 17946000.0 26112000.0 False True 20948623.740856104 15268526.752960103 23410180.72399071 1.0 0.7288558399749141 1.1175044725412595 24.32035213069169 -6.719137149194563 1.7625159045208043 0.8348846435781316 1.1168647737888615 0.5083702380577697 0.11411098836977356 0.35701140447502927 2.1669845384278474 0.05141737170708108 0.12920334452764856 1.9092502265402638e-07 6.719137149194563 0.2819801302107299 MGFNIGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MGFNIGVR 8 0 O43617;A6NKE1;O43617-2 O43617 TRAPPC3 Trafficking protein particle complex subunit 3 0 43531800.0 14337000.0 9003800.0 20191000.0 False True 13881879.782677036 12599064.294196706 14902371.38298382 1.0 0.9075906499290439 1.0735124937171865 23.726699604571614 -6.755525423695221 1.6290990674278087 0.9460265077640405 1.0739926305257446 0.6725217224197539 0.03884686986487818 0.29050063126115033 1.5183869874946951 0.018823335970770523 0.04544141842639287 1.7557981063802883e-07 6.755525423695221 0.12796612276170405 MGFNIGVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MGFNIGVR 8 0 O43617;A6NKE1;O43617-2 O43617 TRAPPC3 Trafficking protein particle complex subunit 3 0 59127000.0 13977000.0 20498000.0 24652000.0 False True 21204130.85557208 16839971.74839503 19779521.39464457 1.0 0.7941835420228873 0.9328145317235134 24.337842013165496 -10.20697885718343 4.541780094050151 1.000032285567089 0.863499036873856 0.5638283731159343 0.056595864566119466 1.957597577559028e-05 3.4180695140948983e-06 0.05481241345652279 0.01826623674177994 6.208992608163709e-11 10.20697885718343 -0.1365332486932329 MGFNIGVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MGFNIGVR 8 0 O43617;A6NKE1;O43617-2 O43617 TRAPPC3 Trafficking protein particle complex subunit 3 0 52187000.0 15979000.0 14339000.0 21869000.0 False True 21886868.116238352 13705455.567267945 16703992.606192803 1.0 0.6261953740699686 0.7631970237806541 24.38356219221458 -10.125842038650417 5.597812439493577 1.0000039026524712 0.6946961999817957 0.8687909667747703 0.05593068928527323 2.724164604369058e-06 4.25419991977729e-07 0.05415534928005978 0.018051552345290947 7.484416738038635e-11 10.125842038650417 -0.30530770267067553 MGFNIGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MGFNIGVR 8 0 O43617;A6NKE1;O43617-2 O43617 TRAPPC3 Trafficking protein particle complex subunit 3 0 32479600.0 14337000.0 9751300.0 8391300.0 False True 11921850.736791061 9698767.811418504 10145882.0330125 1.0 0.8135287067038944 0.8510324661004279 23.50710488000589 -10.426529333566618 5.961370973476225 1.000063960514753 0.8322805864021617 0.9638543792856692 0.015310845659603065 1.3020404968761068e-05 1.25252090064892e-06 0.01483030456574481 0.00494155418799953 3.745162502182689e-11 10.426529333566618 -0.16778337411259125 MGFNIGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MGFNIGVR 8 0 O43617;A6NKE1;O43617-2 O43617 TRAPPC3 Trafficking protein particle complex subunit 3 0 75438000.0 13977000.0 32762000.0 28699000.0 False True 18093502.02785968 30938765.899887394 23476076.47660712 1.0 1.709937957408636 1.2974866026742395 24.108968335257945 -10.393136772699123 4.396239816788692 0.998918230081517 1.5037122800428897 0.6654007611217007 0.16838256047613923 0.0017894730504920864 0.0002470210333503237 0.16336601992328337 0.054345237708770054 4.044484983581531e-11 10.393136772699123 0.5047940499613727 MGGDIANR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MGGDIANR 8 0 Q9UQ80;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 5226800.0 1843600.0 674800.0 2708400.0 False True 1785075.927135619 944251.1590355131 1998988.7897416342 1.0 0.5289697455898607 1.1198340414288515 20.767554009053278 -6.694360609051036 1.8510898781101999 0.7059099772896522 1.1178981555180787 0.39087696167901376 0.19903946055472507 0.4073379753877888 2.70942800337844 0.08591605565298607 0.22249557696941924 2.021340096238643e-07 6.694360609051036 0.4119881782284265 MGGFGSIIQLYPGGGPVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MGGFGSIIQLYPGGGPVR 18 0 Q9UJA5;Q9UJA5-2;Q9UJA5-3;Q9UJA5-4 Q9UJA5 TRMT6 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 0 8388400.0 2062900.0 2875000.0 3450500.0 False True 2704481.8771520155 2446061.2066622246 3093475.3595331665 1.0 0.9044472537704991 1.1438329040647095 21.3669207992872 -6.798375942009875 1.4624428509577263 0.947170150703887 1.1470098813622351 0.8273982743222666 0.04087610599695568 0.22308354251578807 0.942093387599834 0.02198995291887494 0.0511940307253635 1.5908310463010744e-07 6.798375942009875 0.19983973065834815 MGGFGSIIQLYPGGGPVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MGGFGSIIQLYPGGGPVR 18 0 Q9UJA5;Q9UJA5-2;Q9UJA5-3;Q9UJA5-4 Q9UJA5 TRMT6 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 0 9299400.0 4425800.0 1498800.0 3374800.0 False True 4285305.401560435 2097278.6561387437 2490838.638170167 1.0 0.48941171272765027 0.5812511372615735 22.030966594109124 -10.057284175351564 5.232354527433904 1.0000054264990454 0.5353314249937474 0.9715362583174951 0.03749328806642223 2.373413516497731e-06 4.2761485105014506e-07 0.03630314347620847 0.01210090668918083 8.764271539497743e-11 10.057284175351564 -0.46467400150529803 MGGFGSIIQLYPGGGPVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MGGFGSIIQLYPGGGPVR 18 0 Q9UJA5;Q9UJA5-2;Q9UJA5-3;Q9UJA5-4 Q9UJA5 TRMT6 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 0 6206000.0 4425800.0 1780200.0 0.0 False True 3680248.7961839875 1770609.709257966 0.0 1.0 0.48111141591674267 0.0 21.8113718695434 -7.988527829398681 0.581538960162346 1.0137013563038924 3.791843915456349e-18 0.9894784354588456 0.04188589560169401 0.11175734475702714 0.16422422701015857 0.04601117100864233 0.07633682333487447 1.026767634743223e-08 7.988527829398681 -1.0137013563038924 MGGGGAMNMGDPYGSGGQK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MGGGGAMNMGDPYGSGGQK 19 0 P23246;P23246-2;H0Y9K7;H0Y9U2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 30081100.0 5898800.0 13469900.0 10712400.0 False True 7733383.924060461 11460243.425258962 9603983.608596753 1.0 1.4819183345602853 1.2418863078446676 22.88266840678535 -10.157814423152985 4.521551841120902 0.9999452339623274 1.3619023212082864 0.751921376344046 0.09799266459317094 5.563576603925572e-05 1.0362587723802392e-05 0.09489571862395092 0.03162699649740344 6.953213694461039e-11 10.157814423152985 0.361957087245959 MGGGGAMNMGDPYGSGGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MGGGGAMNMGDPYGSGGQK 19 0 P23246;P23246-2;H0Y9K7;H0Y9U2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 23785800.0 7419500.0 1310300.0 15056000.0 False True 7183972.033728967 1833509.6231242295 11112381.929681769 1.0 0.2552222662499027 1.54682978685173 22.776350303189556 -6.750356559104261 1.6485940947576951 0.5622454377847697 1.5494544716797292 0.6504594844279146 0.31296601375714506 0.29943222624751564 1.6013035556137074 0.14995913821612783 0.36391421494578624 1.7768200281530632e-07 6.750356559104261 0.9872090338949595 MGGGGAMNMGDPYGSGGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MGGGGAMNMGDPYGSGGQK 19 0 P23246;P23246-2;H0Y9K7;H0Y9U2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 30038800.0 5898800.0 10346700.0 13793300.0 False True 8079745.769076094 9889548.58203859 10535606.621930564 1.0 1.2239925444051991 1.3039527384950496 22.94587846830824 -13.749841508754033 0.14597061338812212 6.643596132838728e-09 1.3972003022644686 0.9995812969744807 0.0026324261367053703 10.949765122462908 0.11814015788680636 3.1411585448161876 0.08271612931184208 1.7789284930113697e-14 13.749841508754033 1.3972002956208724 MGGGGAMNMGDPYGSGGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MGGGGAMNMGDPYGSGGQK 19 0 P23246;P23246-2;H0Y9K7;H0Y9U2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 11897200.0 7419500.0 2696000.0 1781700.0 False True 6169642.989580891 2681476.1128858994 2154245.2323499736 1.0 0.4346241942060985 0.3491685395715763 22.556755578623832 -13.999999999999998 0.26603583601716363 5.272379471535896 0.3196948072503178 0.9995748775332903 0.005954163728074339 14.692535183504175 0.16324781029742538 33.869137867265955 0.03620905681788101 1.0000000000000041e-14 13.999999999999998 -4.952684664285578 MGGSSGALYGLFLTAAAQPLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MGGSSGALYGLFLTAAAQPLK 21 0 Q3LXA3;H0YCY6;Q3LXA3-2;I3L252 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 37210500.0 7913500.0 17684000.0 11613000.0 False True 12005358.054344272 14528152.034277376 9317685.459841283 1.0 1.2101390036443105 0.7761272439908258 23.517175096145017 -6.775008247023202 1.5549599853718339 1.1197533432346238 0.7731898501143641 0.7494874269063554 0.08869785172319787 0.2583903416664411 1.2335538184257016 0.04494147549595825 0.10650978905136442 1.6787721388222004e-07 6.775008247023202 -0.3465634931202597 MGGSSGALYGLFLTAAAQPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MGGSSGALYGLFLTAAAQPLK 21 0 Q3LXA3;H0YCY6;Q3LXA3-2;I3L252 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 24482100.0 7913500.0 10298000.0 6270600.0 False True 10244181.748405794 9724907.24733046 5129415.141789352 1.0 0.9493102998532662 0.500714968532025 23.288301418237467 -6.9282691960584115 0.7608768827102705 1.0072782070003743 0.4125560778493116 0.9961867090389672 0.013855501217762207 0.09354703638228186 0.08216006057519624 0.012495322107506176 0.040983437390209196 1.1795892443446408e-07 6.9282691960584115 -0.5947221291510627 MGIYVGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MGIYVGAK 8 0 P17858;P17858-2;Q01813;Q5VSR5;V9GYV7 P17858;Q01813 PFKL;PFKP ATP-dependent 6-phosphofructokinase, liver type;ATP-dependent 6-phosphofructokinase, platelet type 0 56025000.0 18490000.0 16107000.0 21428000.0 False True 24240569.057414725 13703898.384594264 19210836.11189006 1.0 0.5653290709527508 0.792507637357376 24.53092023128452 -10.113148457461623 4.960342173522924 1.0000128093856033 0.6789183541538156 0.7270288916104297 0.09274526136904075 1.3138665253901464e-05 2.3490325155251475e-06 0.08980379346706796 0.029933404392878254 7.706399915895161e-11 10.113148457461623 -0.3210944552317877 MGIYVGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MGIYVGAK 8 0 P17858;P17858-2;Q01813;Q5VSR5;V9GYV7 P17858;Q01813 PFKL;PFKP ATP-dependent 6-phosphofructokinase, liver type;ATP-dependent 6-phosphofructokinase, platelet type 0 25875400.0 8596000.0 3316400.0 13963000.0 False True 8323124.685212502 4640655.814797523 10305671.418978916 1.0 0.5575617319589681 1.2381974088756302 22.988693819031774 -6.731254239921442 1.718599692971016 0.7341181935033728 1.2378911285130223 0.5651132655648725 0.18597256646807347 0.3338834558257898 1.9325199633312793 0.08573268072714131 0.21244304789915103 1.8567171978208702e-07 6.731254239921442 0.5037729350096495 MGIYVGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MGIYVGAK 8 0 P17858;P17858-2;Q01813;Q5VSR5;V9GYV7 P17858;Q01813 PFKL;PFKP ATP-dependent 6-phosphofructokinase, liver type;ATP-dependent 6-phosphofructokinase, platelet type 0 28767800.0 8199800.0 10107000.0 10461000.0 False True 12439696.0856779 8303326.88364857 8393378.764780816 1.0 0.6674863136896387 0.6747253877403243 23.568447903615642 -10.097571353182628 4.808145908654697 1.0000150677177129 0.6711058507117786 0.9996367890796588 0.002955339616763593 4.773695251956962e-07 8.959476790454945e-08 0.0028616262708860336 0.0009538317582747045 7.987826934656827e-11 10.097571353182628 -0.32890921700593423 MGIYVGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MGIYVGAK 8 0 P17858;P17858-2;Q01813;Q5VSR5;V9GYV7 P17858;Q01813 PFKL;PFKP ATP-dependent 6-phosphofructokinase, liver type;ATP-dependent 6-phosphofructokinase, platelet type 0 49395000.0 18490000.0 15157000.0 15748000.0 False True 25326252.673461895 14487313.622503683 12028646.740240732 1.0 0.572027524533237 0.47494775067315603 24.59413029280741 -13.999999999999998 0.20844632828670173 3.4594484393293463 0.41689913546451235 0.999489197933386 0.0051552596761787065 12.710795702251543 0.14472112036105964 12.793690174520872 0.05813780184832556 1.0000000000000041e-14 13.999999999999998 -3.042549303864834 MGIYVGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MGIYVGAK 8 0 P17858;P17858-2;Q01813;Q5VSR5;V9GYV7 P17858;Q01813 PFKL;PFKP ATP-dependent 6-phosphofructokinase, liver type;ATP-dependent 6-phosphofructokinase, platelet type 0 20472900.0 8596000.0 5654500.0 6222400.0 False True 7147954.867368057 5624038.086169627 7523475.07087304 1.0 0.7868038047980078 1.0525353349976105 22.76909909446605 -6.693137305267215 1.855814587986726 0.8667329845543962 1.0516403922980095 0.3849918615188812 0.09011033326670709 0.4099094774207059 2.739641281575089 0.03881410315890145 0.10065641931106407 2.027041754639192e-07 6.693137305267215 0.18490740774361336 MGIYVGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MGIYVGAK 8 0 P17858;P17858-2;Q01813;Q5VSR5;V9GYV7 P17858;Q01813 PFKL;PFKP ATP-dependent 6-phosphofructokinase, liver type;ATP-dependent 6-phosphofructokinase, platelet type 0 32928900.0 8199800.0 14923000.0 9806100.0 False True 10614802.7422225 14092521.93162873 8021490.41908281 1.0 1.3276291866991468 0.7556890706198175 23.33957422570809 -6.751359913960414 1.6449029399501622 1.1923372934696537 0.7544408066348556 0.6547417738316295 0.13768214336621687 0.2976914055978097 1.5851761216817617 0.0661108736807957 0.16026509364091232 1.7727197614569548e-07 6.751359913960414 -0.4378964868347981 MGIYYIPVLGPAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MGIYYIPVLGPAPR 14 0 Q9BSC4;Q9BSC4-2;Q9BSC4-4 Q9BSC4 NOL10 Nucleolar protein 10 0 9314000.0 2959700.0 3293900.0 3060400.0 False True 3880195.3617755705 2802462.9595216345 2743739.1654297346 1.0 0.7222479020332709 0.7071136655795095 21.887697861007037 -13.999999999999998 0.41459072489249177 6.144291880176772 0.7065193319750066 0.9998573771600203 0.0016079563092944004 29.05146103795807 0.2140479885760674 135.14628633856816 0.0037241604911554607 1.0000000000000041e-14 13.999999999999998 -5.437772548201766 MGIYYIPVLGPAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MGIYYIPVLGPAPR 14 0 Q9BSC4;Q9BSC4-2;Q9BSC4-4 Q9BSC4 NOL10 Nucleolar protein 10 0 10327400.0 2959700.0 3021900.0 4345800.0 False True 4053981.072885079 2888382.465913035 3319411.5445604613 1.0 0.7124805010146416 0.8188029210995181 21.95090792252993 -10.35277801415094 5.229506910729245 1.000096655053869 0.7656417111987027 0.866276729702187 0.043405946237679106 4.893488205860197e-05 6.056392139531313e-06 0.04204490245497267 0.014009208908735292 4.438354485931212e-11 10.35277801415094 -0.2344549438551663 MGK(ub)IDIDYQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MGKIDIDYQK 10 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 10869600.0 3858400.0 3510000.0 3501200.0 True False 5284954.749339391 3354916.593982183 2674288.669477445 1.0 0.6348051692214661 0.5060192180097145 22.333459688390384 -13.999999999999998 0.1452468225554574 2.7542334911734057 0.35628286943771886 0.9995828693886498 0.004273129067159742 11.943064571869789 0.11976178657060424 5.922893158039896 0.1343902449743738 1.0000000000000041e-14 13.999999999999998 -2.3979506217356867 MGK(ub)IDIDYQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MGKIDIDYQK 10 1 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 1 15639200.0 4920400.0 7174600.0 3544200.0 True False 4091530.610679134 7135949.005753402 4285275.833470721 1.0 1.744078117643348 1.0473527491853294 21.964209214776897 -10.167291209154913 4.428422375869858 0.9999213823950894 1.3957154334257929 0.30075402130676265 0.2844369406406395 31781892.953643378 72968625.64322315 14962.232529569035 0.09737033321170539 6.803130327966169e-11 10.167291209154913 0.3957940510307034 MGLAISLVATEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MGLAISLVATEK 12 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 29187500.0 8721500.0 10330000.0 10136000.0 False True 13231153.127056738 8486530.791341616 8132615.157233389 1.0 0.6414052282402569 0.6146565669021536 23.657435465676222 -13.999999999792003 0.3682693261868479 5.940939816948502 0.6118078708559596 0.9997879231664004 0.002558507372040782 22.61837051620684 0.19681710361965415 88.15899033097489 0.007516269438133999 1.0000000004789312e-14 13.999999999792003 -5.329131946092542 MGLALSSLNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MGLALSSLNK 10 0 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 0 37776000.0 10263000.0 8557000.0 18956000.0 False True 13454892.387033392 7280328.954924758 16994614.95879168 1.0 0.5410915781043987 1.263080704767996 23.681627516482017 -6.7349812420592325 1.7050969676377388 0.7253708040274365 1.2630537133718804 0.5821581778594865 0.19285093441031295 0.3269920867848252 1.8646154642592354 0.0895499242716462 0.22096750284652486 1.8408515093588912e-07 6.7349812420592325 0.537682909344444 MGLALSSLNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MGLALSSLNK 10 0 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 0 26057800.0 6637600.0 3320200.0 16100000.0 False True 6426893.021238549 4645973.174614269 11882927.010353113 1.0 0.7228956759138536 1.8489380437925995 22.615690027537646 -6.8416066033841485 1.274806686741523 0.8525964964704789 1.887191473957772 0.9271920188304185 0.12926352812357544 0.1669358254868374 0.5262762642539434 0.07948468404062095 0.18321472963939214 1.440102474461372e-07 6.8416066033841485 1.0345949774872931 MGLALSSLNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MGLALSSLNK 10 0 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 0 19150500.0 3858500.0 12730000.0 2562000.0 False True 5853626.594135 10458232.04005602 2055619.5770355088 1.0 1.786624389491221 0.3511702606884973 22.480899287743945 -6.757882122068836 1.620232461211348 1.4580980488650817 0.3464180720644392 0.682402336421109 0.3307640572153122 0.28645801319296843 1.4815805998839224 0.16110532312578565 0.3880078358687785 1.7462960752091084e-07 6.757882122068836 -1.1116799768006425 MGLALSSLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MGLALSSLNK 10 0 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 0 30593200.0 10263000.0 9693200.0 10637000.0 False True 14057508.44714654 9264922.37287409 8124759.675891585 1.0 0.6590728654162558 0.5779658398527078 23.74483757800491 -13.999999999999998 0.20170717293672255 2.907597624468774 0.5261684794403585 0.9994870819692571 0.004141232675869744 12.565165798870376 0.14240058338246891 9.463333965606354 0.05099496316996137 1.0000000000000041e-14 13.999999999999998 -2.3814291450284157 MGLALSSLNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MGLALSSLNK 10 0 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 0 16592900.0 6637600.0 6276100.0 3679200.0 False True 5519458.495537723 6242289.403591685 4448503.709301243 1.0 1.130960475314443 0.8059674174373613 22.396095302971922 -6.797309883897542 1.4667360718638363 1.072503928245198 0.8017662269336056 0.8242337520004398 0.05597259452042309 0.22461069494632335 0.954206207199667 0.03002470658177181 0.06994811426885333 1.594740839295632e-07 6.797309883897542 -0.27073770131159247 MGLAMGGGGGASFDR ddPTM_RPMI8226_Bortezomib_1h_R1 3 MGLAMGGGGGASFDR 15 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 45953500.0 11033000.0 17208600.0 17711900.0 False True 14464369.843723966 14641143.958597405 15879242.492541771 1.0 1.012221349203826 1.0978177870245562 23.786000136242436 -6.932657185951156 0.7246544076555733 0.9988179917679292 1.1166412951239229 0.997035083515591 0.002369599481761721 0.09128149118843566 0.07109320482576349 0.002194000936965316 0.0076349972657143855 1.1677310117792441e-07 6.932657185951156 0.11782330335599367 MGLAMGGGGGASFDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MGLAMGGGGGASFDR 15 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 23056000.0 5117300.0 3339700.0 14599000.0 False True 4954854.112568399 4673259.626305422 10775083.939387877 1.0 0.9431679561364502 2.1746521077292633 22.24041114960727 -6.896082525660102 0.9857139851183848 0.9431521596832149 2.2941025929149044 0.984514088887881 0.07063427173963395 0.11434617757900957 0.19413333696543916 0.054115658913494735 0.13822478959848009 1.2703326906630046e-07 6.896082525660102 1.3509504332316895 up MGLAMGGGGGASFDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MGLAMGGGGGASFDR 15 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 26811700.0 4034500.0 16194000.0 6583200.0 False True 6120631.46145851 13304054.17570051 5282027.634480936 1.0 2.17364078518301 0.8629873678462354 22.54524907180405 -6.670651191044285 1.934702992838469 1.7487364511186827 0.8682442794460097 0.28188024914110366 0.49846848734484517 0.45975613242077573 3.3182539027216458 0.20735380348991903 0.5536003744078186 2.1347587825742454e-07 6.670651191044285 -0.880492171672673 MGLAMGGGGGASFDR ddPTM_RPMI8226_Carfilzomib_1h_R1 3 MGLAMGGGGGASFDR 15 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 39397900.0 11033000.0 12821300.0 15543600.0 False True 15112198.255614093 12254812.571630696 11872521.810490593 1.0 0.8109219032431702 0.7856250698722815 23.849210197765327 -13.999999999999998 0.28348328103734505 2.570947288031844 0.7782674985218248 0.9996129066573236 0.0018819523428503133 15.589702434805398 0.16871733582687368 14.227988161428412 0.009843956422378876 1.0000000000000041e-14 13.999999999999998 -1.7926797895100193 MGLAMGGGGGASFDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MGLAMGGGGGASFDR 15 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 13226900.0 5117300.0 4376300.0 3733300.0 False True 4255261.684828127 4352724.003272459 4513915.769171111 1.0 1.0229039541309124 1.0607845306588781 22.020816425041545 -6.963583466143547 0.38158338148097326 0.9974438515213968 1.0875875607964594 0.9998808487426926 0.0002735396788319067 0.07844499708420537 0.01657547786822661 0.0004922052210769285 0.00319846748051201 1.087468119334361e-07 6.963583466143547 0.09014370927506254 MGLAMGGGGGASFDR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MGLAMGGGGGASFDR 15 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 31949900.0 6227300.0 16694000.0 9028600.0 False True 8061362.60843463 15764964.22479459 7385487.441259112 1.0 1.9556202828910907 0.9161586942549456 22.942592286772257 -6.664950663716725 1.955006392731305 1.6125758991901906 0.9204115847380396 0.25704024716142604 0.4064007806127055 0.4727836076665694 3.478589680974029 0.16763588695362128 0.4508945258237918 2.162964224648968e-07 6.664950663716725 -0.692164314452151 MGLLAVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MGLLAVLR 8 0 D6RCD1;D6RC77;D6RCQ8;D6RF77;A0A494C163;A0A494C099;A0A494C0G1;H0Y987;O95394;O95394-3;O95394-4 D6RCD1 PGM3 Phosphoacetylglucosamine mutase 0 2016890.0 457590.0 836340.0 722960.0 False True 599904.9213078632 711561.3320277858 648155.0343220105 1.0 1.1861235118333393 1.0804296002589149 19.1943743411129 -10.719430905172915 4.817509582468423 0.9940692524783887 1.1332765560460258 0.6794924197082031 0.04314935871270201 0.00285876310751777 0.00016649259438002815 0.04345403182008678 0.013926395641151404 1.907959249900795e-11 10.719430905172915 0.1392073035676371 MGLLAVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MGLLAVLR 8 0 D6RCD1;D6RC77;D6RCQ8;D6RF77;A0A494C163;A0A494C099;A0A494C0G1;H0Y987;O95394;O95394-3;O95394-4 D6RCD1 PGM3 Phosphoacetylglucosamine mutase 0 2008990.0 457590.0 596090.0 955310.0 False True 626773.3889047819 569752.7727939705 729685.4532270365 1.0 0.909025148290918 1.1641934168616863 19.257584402635793 -6.810332359195945 1.4133680166336373 0.9504393963135913 1.1686815036593468 0.8606325525577548 0.03941949565610369 0.20635177932563853 0.8124052145340124 0.02193115175423454 0.050718156465812535 1.547631785700573e-07 6.810332359195945 0.21824210734575544 MGLSMER ddPTM_RPMI8226_Bortezomib_1h_R1 1 MGLSMER 7 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 11442800.0 2610700.0 4202500.0 4629600.0 False True 3422652.9820547667 3575503.3812167007 4150573.4022590164 1.0 1.0446584564556618 1.2126772489121136 21.70668359627681 -6.94628378673519 0.598257851740237 0.9981000343800517 1.2678108529396779 0.9988763968231116 0.00306924970659418 0.08501330309816743 0.04240981154535659 0.0031555344129347443 0.01411189969827202 1.1316606457328978e-07 6.94628378673519 0.2697108185596262 MGLSMER ddPTM_RPMI8226_Bortezomib_2h_R1 1 MGLSMER 7 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 6906520.0 2003400.0 793220.0 4109900.0 False True 1939803.163605716 1109956.882587654 3033393.8956428687 1.0 0.5722007796525398 1.5637637635379358 20.8874788355009 -6.789461838558274 1.498555128544175 0.7607368125228142 1.574143383984642 0.799557535697845 0.18180099468088293 0.23615290750796755 1.0476899057540314 0.09549557041039744 0.22365949374125288 1.6238210293137668e-07 6.789461838558274 0.8134065714618277 MGLSMER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MGLSMER 7 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 8550300.0 2610700.0 2676800.0 3262800.0 False True 3575946.34151471 2558530.1250061244 2492193.8394753267 1.0 0.7154833659842823 0.6969326722110925 21.769893657799702 -13.999999999999998 0.3880646207468194 5.443298830709689 0.6955279551567725 0.9998201926589694 0.0018598745207685887 25.085940034741974 0.20397641415346238 93.42467784344358 0.004909609501627972 1.0000000000000041e-14 13.999999999999998 -4.747770875552916 MGNIFANLFK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MGNIFANLFK 10 0 P84077 P84077 ARF1 ADP-ribosylation factor 1 0 7451470.0 1428300.0 2187930.0 3835240.0 False True 1872515.131676874 1861499.3724843443 3438406.1550198435 1.0 0.9941171320828448 1.836250130561393 20.83654594638309 -6.9053265153006 0.926979760651773 0.9699172817357342 1.9348648281262741 0.9890349148031529 0.04142560474031176 0.10759039651834817 0.15613405671147426 0.03315064212267741 0.08880173354661636 1.243579300908129e-07 6.9053265153006 0.9649475463905399 MGNIFANLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MGNIFANLFK 10 0 P84077 P84077 ARF1 ADP-ribosylation factor 1 0 9589100.0 3140500.0 2330400.0 4118200.0 False True 3040806.546522788 3260940.872875459 3039519.876648209 1.0 1.072393400561571 0.999576865593094 21.53602260560413 -6.647518010861553 2.0175595493886953 1.0470679544876649 0.9998833140396138 0.18403975726930277 0.030917196719032602 0.514597736174124 4.012216267513513 0.012440694673916551 0.034237905909603884 2.2515520394749323e-07 6.647518010861553 -0.04718464044805104 MGNIFANLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MGNIFANLFK 10 0 P84077 P84077 ARF1 ADP-ribosylation factor 1 0 11240180.0 1428300.0 3412180.0 6399700.0 False True 1956381.1083561694 3261418.605029664 4888222.665958763 1.0 1.6670671123838647 2.498604512730163 20.89975600790598 -6.968150266155005 0.29908933644565794 0.8542139033547204 3.337479477421113 0.9999641443894296 0.003670789861510817 0.07690761107472047 0.011167181962024193 0.013858156061133385 0.07464912237969187 1.0760928204387441e-07 6.968150266155005 2.4832655740663925 MGNIFANLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MGNIFANLFK 10 0 P84077 P84077 ARF1 ADP-ribosylation factor 1 0 6001500.0 3140500.0 1421200.0 1439800.0 False True 2611464.8977395766 1413543.713513888 1740855.5231169662 1.0 0.5412838268427114 0.6666203036555499 21.316427881038408 -10.332570773512888 8.5495711052038 1.0000007789581462 0.603952065249139 0.9301339448615336 0.051168402391604945 7.597255656252521e-07 5.940916161877792e-08 0.049543690017018804 0.016514530859560467 4.649745967853265e-11 10.332570773512888 -0.3960487137090072 MGPAMGPALGAGIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 MGPAMGPALGAGIER 15 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 42862100.0 8286100.0 14385000.0 20191000.0 False True 10863157.342706552 12238814.07229082 18101829.005748183 1.0 1.1266350735965243 1.6663506229983518 23.372940143103417 -6.943420353640261 0.6269430000135304 0.994111060259552 1.8278099689963778 0.9985783842752043 0.010894107403548662 0.0862404489176596 0.04776127370928848 0.010902742255297753 0.04579868295126965 1.1391466737003989e-07 6.943420353640261 0.8336989087368258 MGPAMGPALGAGIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 MGPAMGPALGAGIER 15 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 24158800.0 7824000.0 3086800.0 13248000.0 False True 7575631.40264108 4319375.337449344 9777951.36851913 1.0 0.5701670405906347 1.2907110772456878 22.852934706556226 -6.7451524971172 1.6680949044754059 0.7457848036131626 1.2916037160774103 0.6277295005220231 0.1805909424557474 0.30857429109621565 1.6877876310149116 0.08558546662579944 0.20882168837735196 1.7982393748183667e-07 6.7451524971172 0.5458189124642477 MGPAMGPALGAGIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MGPAMGPALGAGIER 15 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 32094100.0 8286100.0 12610000.0 11198000.0 False True 11349695.093432806 12052848.504306342 8553263.030049257 1.0 1.0619535066876287 0.7536117014278534 23.43615020462631 -6.854436626633653 1.2134647416162658 1.033232484469897 0.7401871841977613 0.9465188553850742 0.03079802544667445 0.15264388133594572 0.4303010392481118 0.019834811093240444 0.04604934687387263 1.3981809265897295e-07 6.854436626633653 -0.2930453002721357 MGPAMGPALGAGIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MGPAMGPALGAGIER 15 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 10663400.0 7824000.0 2839400.0 0.0 False True 6506002.661969262 2824103.5886232248 0.0 1.0 0.4340766113010495 0.0 22.633339981990503 -8.150389421841654 0.5549290002060608 1.0232864713602117 2.953927305567186e-16 0.9908120760439518 0.03924530419029856 0.12127072822882155 0.17105653864152537 0.051361878210689355 0.07390887234406673 7.073112702529801e-09 8.150389421841654 -1.0232864713602114 MGPLGLDHMASSIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 MGPLGLDHMASSIER 15 0 P52272-2;P52272;A0A087X0X3;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 25167700.0 3292700.0 11162000.0 10713000.0 False True 4316761.586552155 9496673.10913523 9604521.526352353 1.0 2.199953117336815 2.2249367572842007 22.04151798470935 -10.8718762409946 0.6762611741592011 5.449452608689583e-16 2.2208637795178476 0.9999546321720991 0.003850334080628308 2.651771674627532 0.34174430615395973 4.232667477971762 0.003982902217640358 1.3431476575407415e-11 10.8718762409946 2.220863779517847 MGPLGLDHMASSIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 MGPLGLDHMASSIER 15 0 P52272-2;P52272;A0A087X0X3;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 18290600.0 6191100.0 2803100.0 9296400.0 False True 5994566.919336803 3922392.4479733882 6861393.9539780505 1.0 0.6543245743609672 1.1446021115962697 22.51522409846089 -6.717253834893333 1.7691806539888943 0.7890809384770129 1.1437232939682545 0.4995307573485802 0.14551263480162024 0.36068248190926017 2.204784375128533 0.06534469192909889 0.16457283135824488 1.9175476516493596e-07 6.717253834893333 0.35464235549124157 MGPLGLDHMASSIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MGPLGLDHMASSIER 15 0 P52272-2;P52272;A0A087X0X3;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 26053000.0 3292700.0 9366300.0 13394000.0 False True 4510100.171871707 8952465.895787831 10230613.058088914 1.0 1.9849816089722299 2.2683782329036775 22.104728046232243 -10.468170321414954 0.26776324568855586 7.889234332541827e-14 2.392830600382792 0.9991066596315079 0.016246869850323413 2.0671880402669354 0.13092446246624476 1.5205292172096376 0.11747601878346103 3.4027471474476136e-11 10.468170321414954 2.392830600382713 MGPLGLDHMASSIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MGPLGLDHMASSIER 15 0 P52272-2;P52272;A0A087X0X3;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 9098400.0 6191100.0 1786200.0 1121100.0 False True 5148173.962233878 1776577.3860670603 1355516.8266192733 1.0 0.3450888410336806 0.2633005093773273 22.295629373895167 -13.999999999999998 0.29337422729343754 6.752056587601116 0.24176103898807946 0.999635016239349 0.006298783904685656 16.169566184294066 0.17184253988263704 56.24347729057399 0.03042622790760837 1.0000000000000041e-14 13.999999999999998 -6.510295548613036 MGQMAMGGAMGINNR ddPTM_RPMI8226_Bortezomib_1h_R1 4 MGQMAMGGAMGINNR 15 0 Q15233;Q15233-2 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 130559500.0 47394800.0 35179800.0 47984900.0 False True 62135041.771896034 29931110.969786327 43019882.85166295 1.0 0.48171064372446126 0.6923610514272003 25.888903786641773 -10.223947475296185 5.50294418783218 1.0000221482095513 0.5870358475758038 0.8367173816168714 0.08599766883025638 2.3369185467035155e-05 3.2958875928461105e-06 0.08327134256531117 0.027755628266006162 5.971074979503257e-11 10.223947475296185 -0.4129863006337474 MGQMAMGGAMGINNR ddPTM_RPMI8226_Bortezomib_2h_R1 3 MGQMAMGGAMGINNR 15 0 Q15233;Q15233-2 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 54541500.0 17104700.0 5393600.0 32043200.0 False True 16561720.661139421 7547292.607252429 23650124.644605365 1.0 0.4557070344122799 1.427999247692798 23.981349231996596 -6.754818484476392 1.6322665493240467 0.6818113178861503 1.4306349429567373 0.6693515121453579 0.22879024115899257 0.2917078838815629 1.5305344126924592 0.11066715917253368 0.2672981660722271 1.7586585003791998e-07 6.754818484476392 0.748823625070587 MGQMAMGGAMGINNR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MGQMAMGGAMGINNR 15 0 Q15233;Q15233-2 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 67262500.0 7885300.0 48943900.0 10433300.0 False True 11962576.592648122 40209478.64456392 8371153.681922171 1.0 3.3612724092630333 0.6997784814240485 23.51202482607894 -6.672650618134542 1.9282582999664692 2.5037983226470057 0.710493328836123 0.2906582258655941 1.0024195276813894 0.45510113044370143 3.2648672963821475 0.418166222541052 1.1132738016825972 2.1249532600931942e-07 6.672650618134542 -1.7933049938108827 MGQMAMGGAMGINNR ddPTM_RPMI8226_Carfilzomib_1h_R1 3 MGQMAMGGAMGINNR 15 0 Q15233;Q15233-2 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 91476100.0 43309500.0 21913100.0 26253500.0 False True 59322192.54522973 20944906.78506862 20052964.007804785 1.0 0.3530703415774685 0.3380347749708604 25.82206858492508 MGQMAMGGAMGINNR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MGQMAMGGAMGINNR 15 0 Q15233;Q15233-2 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 29585900.0 14364800.0 7526200.0 7694900.0 False True 11944967.668539887 7485654.866766264 9303868.012802277 1.0 0.6266785373125489 0.7788943654746242 23.50989961306645 -10.280826545681586 5.1426011796166495 1.0000595175859175 0.7027864513935247 0.8356188801345676 0.0621418516289347 4.241332568752028e-05 5.931289457167607e-06 0.06018060783885544 0.020056196371747166 5.2380960087323534e-11 10.280826545681586 -0.2972730661923928 MGQMAMGGAMGINNR ddPTM_RPMI8226_Carfilzomib_8h_R1 4 MGQMAMGGAMGINNR 15 0 Q15233;Q15233-2 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 73805800.0 13122700.0 42398900.0 18284200.0 False True 16987593.837089118 40039363.94337149 14956663.211734932 1.0 2.356976763592811 0.8804462453699569 24.01797818447156 -6.665032891805837 1.954794560214143 1.8698012859518258 0.8864952062318192 0.25735931721366934 0.5770774227158988 0.47259378263096496 3.476546741815356 0.2380614583493671 0.6402322958329282 2.1625547338862064e-07 6.665032891805837 -0.9833060797200066 MGTLVSLEPSSVASDVSK(ub)PVLTTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MGTLVSLEPSSVASDVSKPVLTTK 24 1 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 1 11680700.0 3173000.0 5655800.0 2851900.0 True False 4159833.7273757076 4811976.686135732 2556812.745356506 1.0 1.1567714003731198 0.6146430153037653 21.988094432910597 -6.829343676049687 1.3307051935823027 1.083811508390605 0.6002364894352541 0.9045695060816911 0.07036742934468602 0.18163161638828976 0.6292330062113783 0.04152009522536594 0.09555881395550209 1.4813453683917559e-07 6.829343676049687 -0.48357501895535093 MGTLVSLEPSSVASDVSK(ub)PVLTTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MGTLVSLEPSSVASDVSKPVLTTK 24 1 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 1 17797600.0 6489700.0 7393600.0 3914300.0 True False 6283688.025782181 10345903.037114639 2889027.403517087 1.0 1.6464698748036273 0.45976620603430846 22.583180124426416 -6.758759299703451 1.6169850756269197 1.376082187703917 0.45567059018569445 0.6859453346532005 0.2718620561440938 0.2850048194624682 1.4683772132282706 0.1326689801510571 0.31923602826925446 1.742772507660351e-07 6.758759299703451 -0.9204115975182227 MGTLVSLEPSSVASDVSK(ub)PVLTTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MGTLVSLEPSSVASDVSKPVLTTK 24 1 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 1 12060300.0 3173000.0 4211700.0 4675600.0 True False 4346143.847100838 4025613.16777058 3571319.5770046655 1.0 0.9262494085316405 0.8217214391987897 22.051304494433488 -6.966182511496553 0.33714429295199255 1.0117192464092737 0.732792836292278 0.9999354778806074 0.0005874939930860966 0.07756197604060104 0.013457690501966454 0.0014888047347275137 0.009066546722823142 1.0809795760529359e-07 6.966182511496553 -0.2789264101169957 MGTLVSLEPSSVASDVSK(ub)PVLTTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MGTLVSLEPSSVASDVSKPVLTTK 24 1 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 1 16167600.0 6489700.0 8111900.0 1566000.0 True False 5396473.092456785 8068199.584613914 1893443.3596340928 1.0 1.4950875222358988 0.35086682119860035 22.363585399860693 -6.789099545963018 1.499831932972391 1.277024517912938 0.3389797334864728 0.7984369085078673 0.21035249552404747 0.2366883927286642 1.0518347713686975 0.11039759170781503 0.2586491142543325 1.625176201460204e-07 6.789099545963018 -0.9380447844264652 down MGVPYCIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MGVPYCIIK 9 0 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 9576200.0 2059700.0 4131900.0 3384600.0 False True 2700286.6461631735 3515436.6260200506 3034394.0593757248 1.0 1.3018753512761767 1.1237303505119662 21.364681132543875 -10.217020722158965 3.9177941902307007 0.999830305075216 1.2128028507748558 0.6554806877384554 0.07272739255071925 9719677.334463408 8507654.452195423 13176.471424014058 0.024896521164111854 6.067073801377394e-11 10.217020722158965 0.21297254569963986 MGVPYCIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MGVPYCIIK 9 0 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 9867800.0 2059700.0 3615200.0 4192900.0 False True 2821226.751299591 3455468.5101322993 3202623.3754861173 1.0 1.224810628405018 1.1351882205181973 21.427891194066767 -10.210312763965328 4.56918686944784 0.999955634810697 1.1799994244633223 0.8432192402037311 0.036588194812897074 1.6539822336294104e-05 2.858550611086497e-06 0.035435090867614545 0.01180878909735494 6.161511111813555e-11 10.210312763965328 0.18004378965262524 MGVVECAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MGVVECAK 8 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 4975110.0 2319000.0 541110.0 2115000.0 False True 2245384.614356421 757178.044851373 1561018.0513600498 1.0 0.3372152993345408 0.6952118765663999 21.098531156249994 -10.674482458106624 6.842762289745078 1.0028655929892412 0.5162135879507586 0.708874126111399 0.1461514906468208 0.006414020166619458 0.00030512148586862587 0.14205879917340375 0.047170190774877156 2.116009152726375e-11 10.674482458106624 -0.4866520050384826 MHCCDEVQPK(ub)HVK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MHCCDEVQPKHVK 13 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 77006100.0 16602200.0 37149000.0 23254900.0 True False 21765644.97593349 31606514.00566785 20848706.02475227 1.0 1.4521285282662433 0.9578721902247745 24.3755494359934 -6.666076459313477 1.9511903496835676 1.2895642721902656 0.9598989016263481 0.26174098036325744 0.19223078934686474 0.4702432974103431 3.447579723495818 0.07941954933429683 0.21328778916830193 2.1573645628934133e-07 6.666076459313477 -0.32966537056391754 MHCCDEVQPK(ub)HVK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MHCCDEVQPKHVK 13 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 115170060.0 49509100.0 42174560.0 23486400.0 True False 75108924.30003609 34648180.25665875 18844302.745545186 1.0 0.4613057713122128 0.25089299202672954 26.162481000426197 -12.62737486115946 0.14813180344290583 2.74123914097278 1.9253522112233276e-18 0.9995947471343253 0.006350457835740558 7.125977887830937 0.10816408338474183 3.8881477566692317 0.20801333988728304 2.3584416661175197e-13 12.62737486115946 -2.74123914097278 MHCCDEVQPK(ub)HVK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MHCCDEVQPKHVK 13 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 80102410.0 16602200.0 40949910.0 22550300.0 True False 22740481.9975851 39140607.5729564 17224383.57800675 1.0 1.7211863661074946 0.7574326515962096 24.43875949751629 -6.706417377945281 1.807880382647821 1.4449873244842484 0.7599222675214176 0.44806754426687045 0.3040809745876815 0.38234915390049745 2.4337176909074993 0.13396183026963712 0.3418248700822066 1.965995964553861e-07 6.706417377945281 -0.6850650569628308 MHCCDEVQPK(ub)HVK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MHCCDEVQPKHVK 13 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 106923100.0 49509100.0 44612000.0 12802000.0 True False 64090505.920262456 42129302.98290024 10472167.359612681 1.0 0.6573407773581157 0.16339654694942682 25.933607322518647 -7.407307294298403 0.46398688021602297 1.0189412366420596 4.9294794629331993e-23 0.9984276099956205 0.013616900045491744 0.11124885146425009 0.0521990061107773 0.016922913451625273 0.06228698787775312 3.914647898510771e-08 7.407307294298403 -1.0189412366420596 down MHDYDGNNLLDGLELSTAITHVHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MHDYDGNNLLDGLELSTAITHVHK 24 0 Q8NI22-2;Q8NI22-3;Q8NI22;H7BZ18;A0A3B3IU18 Q8NI22-2 MCFD2 Multiple coagulation factor deficiency protein 2 0 5824940.0 618740.0 2269000.0 2937200.0 False True 847504.8988197848 2168748.077420388 2243493.853532831 1.0 2.558979989898035 2.647175086134685 19.69286218189828 -10.608860729249836 0.5487342449941116 8.66837156742631e-16 2.639980607672929 0.9997671652482928 0.011544217519394093 2.0786439700705968 0.2647619411259472 2.874055343921848 0.016479601978615716 2.461156728127318e-11 10.608860729249836 2.639980607672928 MHGGGPTVTAGLPLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MHGGGPTVTAGLPLPK 16 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 8170600.0 1803600.0 2109700.0 4257300.0 False True 2364537.0660872483 1794940.9835461911 3816795.434905245 1.0 0.7591088375351187 1.6141829576903788 21.17312632674312 -6.831488521491032 1.3213933621866967 0.871415164099447 1.6378755179030287 0.9087921928069576 0.10872231603303426 0.17898231970225514 0.6106988153150499 0.06459425415776289 0.14863475659910985 1.4740474998935212e-07 6.831488521491032 0.7664603538035817 MHGGGPTVTAGLPLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MHGGGPTVTAGLPLPK 16 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 7333900.0 2126400.0 1229600.0 3977900.0 False True 2058898.5959325128 1720585.692279292 2935968.6555579854 1.0 0.8356825808121003 1.4259899255641737 20.973441345992804 -6.832443689571366 1.3170854097701217 0.9123401512492255 1.4426675091177767 0.9106507801067214 0.07435746678836241 0.17781563459414923 0.6024173164498117 0.044316976775538315 0.10197805467086699 1.4708091074940074e-07 6.832443689571366 0.5303273578685512 MHGGGPTVTAGLPLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MHGGGPTVTAGLPLPK 16 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 7398000.0 1803600.0 2749000.0 2845400.0 False True 2470439.660457323 2627540.090272655 2173375.122852484 1.0 1.0635920934762884 0.8797523605373764 21.23633638826601 -6.8132786795889215 1.4005619122725108 1.0345251670926963 0.876284485886229 0.8682582564976778 0.027668992556566064 0.20235685935489922 0.7816608247839195 0.015530740528994688 0.03587789145489243 1.5371679485061608e-07 6.8132786795889215 -0.15824068120646728 MHGGGPTVTAGLPLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MHGGGPTVTAGLPLPK 16 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 4119470.0 2126400.0 878670.0 1114400.0 False True 1768195.8154922582 873936.4303076615 1347415.8875965734 1.0 0.4942531944994799 0.7620286598299966 20.75384662142708 -10.036055821246155 5.139281682848294 1.0000041342593855 0.6281409271632422 0.7199904694466184 0.10931887595456613 5.17848728606841e-06 9.713636661626558e-07 0.10584872287348536 0.035282515499096154 9.203312710555068e-11 10.036055821246155 -0.3718632070961433 MHIFSMNMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MHIFSMNMK 9 0 Q9UBT2;Q9UBT2-2;K7ESK7 Q9UBT2 UBA2 SUMO-activating enzyme subunit 2 0 13681800.0 3904300.0 4265100.0 5512400.0 False True 5118575.109294981 3628763.70522959 4942029.726674578 1.0 0.7089402085045122 0.9655088811142366 22.28731082313261 -10.235150377138883 7.291336106590395 1.0000004313335993 0.8372245451465972 0.3492432385635057 0.10474372197950253 7.344990966445626e-07 7.689584035821738e-08 0.10141794170777085 0.03380589090386609 5.819016958380598e-11 10.235150377138883 -0.16277588618700212 MHIFSMNMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MHIFSMNMK 9 0 Q9UBT2;Q9UBT2-2;K7ESK7 Q9UBT2 UBA2 SUMO-activating enzyme subunit 2 0 8561900.0 3193800.0 1025700.0 4342400.0 False True 3092414.5671977364 1435267.358954837 3204995.170792378 1.0 0.46412514485580053 1.036405404627446 21.560302308363273 -11.828607796642354 14.022467828262263 0.9104310445295875 0.7752387472674461 0.0 0.2680281808889431 0.0 0.0 0.0 0.07779956533097043 1.4838575246779096e-12 11.828607796642354 -0.13519229726214133 MHIFSMNMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MHIFSMNMK 9 0 Q9UBT2;Q9UBT2-2;K7ESK7 Q9UBT2 UBA2 SUMO-activating enzyme subunit 2 0 12882600.0 2852200.0 3062600.0 6967800.0 False True 4326995.923750644 2516055.1017969814 5590611.275904765 1.0 0.5814785005889405 1.2920306315100059 22.044934330992806 -6.747100733921218 1.6604866709812867 0.7530422181761989 1.293140403434553 0.6363630946692926 0.17584745518665731 0.305167665246027 1.65453618832418 0.08368816878002966 0.2038015910016856 1.790190573990658e-07 6.747100733921218 0.5400981852583542 MHIFSMNMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MHIFSMNMK 9 0 Q9UBT2;Q9UBT2-2;K7ESK7 Q9UBT2 UBA2 SUMO-activating enzyme subunit 2 0 15980700.0 3904300.0 4641100.0 7435300.0 False True 5347825.219740247 4436040.8559346665 5679235.274810253 1.0 0.8295037092012765 1.0619709959567643 22.350520884655502 -6.710078347145848 1.7944916642650275 0.8951965030007423 1.0614373853254822 0.46573098109332933 0.07184467831282979 0.3748878332130651 2.353212503246304 0.031856991468233745 0.08093718299746291 1.949492877627148e-07 6.710078347145848 0.16624088232473988 MHIFSMNMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MHIFSMNMK 9 0 Q9UBT2;Q9UBT2-2;K7ESK7 Q9UBT2 UBA2 SUMO-activating enzyme subunit 2 0 7666000.0 3193800.0 2854300.0 1617900.0 False True 2655786.209329938 2838923.3193658087 1956195.4096756063 1.0 1.0689577758151236 0.7365786458275042 21.34070758379755 -6.852586095925502 1.2225424472947355 1.0368963061433838 0.7226132486876619 0.9439854157407362 0.03389774992689343 0.15463490431430296 0.4434510433893871 0.021681234219008166 0.050261819264618826 1.40415129254632e-07 6.852586095925502 -0.31428305745572194 MHIFSMNMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MHIFSMNMK 9 0 Q9UBT2;Q9UBT2-2;K7ESK7 Q9UBT2 UBA2 SUMO-activating enzyme subunit 2 0 16898100.0 2852200.0 7787600.0 6258300.0 False True 3692229.125267327 7354213.214149423 5119353.6155806985 1.0 1.9918084616747502 1.386521107410972 21.816060653085255 -10.726929523750563 6.67416384645745 0.9896293500129677 1.6891647845428608 0.6334941458282839 0.2471075276175821 0.03774602058206261 0.0015443596319754608 0.23683840311429594 0.07975361159878207 1.8752988022931527e-11 10.726929523750563 0.6995354345298931 MHILLGLMGLQVGELHGNLSQTQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MHILLGLMGLQVGELHGNLSQTQR 24 0 Q96GQ7;B7Z6D5 Q96GQ7 DDX27 Probable ATP-dependent RNA helicase DDX27 0 29824000.0 6907500.0 9029500.0 13887000.0 False True 10479182.505892847 7418115.177194498 11142228.363111682 1.0 0.7078906367956667 1.0632726700623811 23.321022839035738 -6.6882632418183805 1.872199705167789 0.8165758095590768 1.062033362577642 0.3625211390780736 0.12358447436490351 0.4203909664474634 2.855433407448932 0.05282965343601332 0.13789368933620405 2.0499192709023877e-07 6.6882632418183805 0.2454575530185651 MHILLGLMGLQVGELHGNLSQTQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MHILLGLMGLQVGELHGNLSQTQR 24 0 Q96GQ7;B7Z6D5 Q96GQ7 DDX27 Probable ATP-dependent RNA helicase DDX27 0 31230800.0 6907500.0 17722900.0 6600400.0 False True 8941894.917181147 16736605.035318825 5399194.9258231195 1.0 1.8717067456430019 0.6038088096348562 23.092149161128187 -6.7216837970416465 1.7530438693621482 1.529386682947763 0.6055721944408258 0.5204724594654713 0.3667457275192833 0.35209472047769075 2.1155157523697516 0.16604537774467046 0.41604625085391167 1.898087385709293e-07 6.7216837970416465 -0.9238144885069371 MHK(ub)EEHEVAVLGPPPSTILPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MHKEEHEVAVLGPPPSTILPR 21 1 P13164 P13164 IFITM1 Interferon-induced transmembrane protein 1 1 11938800.0 2631000.0 5797600.0 3510200.0 True False 3449266.4786402406 4932620.678867794 3146998.1762160035 1.0 1.4300491740528891 0.9123673672950324 21.717858160158848 -6.686193408779174 1.8798153776285969 1.270576489018546 0.9142313454815915 0.3526109961907202 0.1820249915510863 0.4249690121661274 2.90845258372664 0.07754826985255368 0.202924843061442 2.0597124363002866e-07 6.686193408779174 -0.35634514353695457 MHK(ub)EEHEVAVLGPPPSTILPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MHKEEHEVAVLGPPPSTILPR 21 1 P13164 P13164 IFITM1 Interferon-induced transmembrane protein 1 1 11902000.0 2631000.0 4880400.0 4390600.0 True False 3603751.800101577 4664767.79067539 3353630.7072454193 1.0 1.2944198295076554 0.9305942510110969 21.78106822168174 -6.691445004108338 1.8615551084880366 1.184338734104416 0.931840194914437 0.37702226239154624 0.1244836249879191 0.413598820545525 2.780060832460543 0.05347666855434429 0.13898980129131544 2.0349558715328104e-07 6.691445004108338 -0.252498539189979 MHLYLGAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MHLYLGAAK 9 0 Q13085-3;Q13085-2;Q13085;Q13085-4;Q59FY4;O00763-3;O00763-2;O00763;F8W8T8;H0YGH5 Q13085-3 ACACA;ACACB Acetyl-CoA carboxylase 1;Biotin carboxylase;Acetyl-CoA carboxylase 2;Biotin carboxylase 0 6153400.0 2266100.0 0.0 3887300.0 False True 2970879.04494362 0.0 3485079.485614626 1.0 0.0 1.1730802341300854 21.50245843844491 -10.761994089288589 6.176486816291553 1.0140085442926483 0.5865401170650428 0.14209793593317632 0.47890800016055557 0.09186619499458927 0.003539985479172465 0.4611105394349934 0.1545668924156108 1.7298399020306274e-11 10.761994089288589 -0.4274684272276055 MHSLLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MHSLLIK 7 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 5930700.0 2085600.0 1923000.0 1922100.0 False True 2734241.796979131 1636095.895795291 1723219.5300851152 1.0 0.5983727911711747 0.6302367010807083 21.382709399641154 -10.10253789959068 5.326308789032578 1.0000063985861392 0.6143047461256571 0.9949072368316126 0.013008386749057957 9.884189561520522e-07 1.6653708965806912e-07 0.012595525125380081 0.004198438769866676 7.896999316231838e-11 10.10253789959068 -0.38570165246048205 MHSLLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MHSLLIK 7 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 4802900.0 2085600.0 1214700.0 1502600.0 False True 2856702.6812207745 1161030.5375242603 1147716.8270183974 1.0 0.4064233023466443 0.4017627856630623 21.445919461164046 MHSPQTSAMLFTVDNEAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MHSPQTSAMLFTVDNEAGK 19 0 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 20220500.0 4396900.0 6980200.0 8843400.0 False True 5764378.479640174 5938781.368606489 7928369.799882799 1.0 1.0302552807006529 1.3754075704580917 22.458733632937776 -6.924134373211259 0.7934394303642418 0.9934587153433401 1.436731987590478 0.9952550038338498 0.011729977656616717 0.09579920794548788 0.09344607537741567 0.01033467762137652 0.032295670644340246 1.1908734879107684e-07 6.924134373211259 0.443273272247138 MHSPQTSAMLFTVDNEAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MHSPQTSAMLFTVDNEAGK 19 0 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 14648100.0 4303900.0 1428900.0 8915300.0 False True 4167275.050335751 1999467.2216150626 6580115.4767329795 1.0 0.4798020762881895 1.5789971617550969 21.990672893905014 -6.777998091595629 1.54349051189101 0.7046841532258459 1.5871909367676014 0.7602941441564957 0.21980901398206032 0.2537020099488454 1.193656550876401 0.11217716908352064 0.2651572375005132 1.6672545388906577e-07 6.777998091595629 0.8825067835417555 MHSPQTSAMLFTVDNEAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MHSPQTSAMLFTVDNEAGK 19 0 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 21745900.0 4396900.0 9276300.0 8072700.0 False True 6022552.751754712 8866442.393378029 6166094.522475318 1.0 1.4722066802643994 1.0238340412508273 22.521943694460667 -10.42145622342203 3.170101934018307 0.9963768837885884 1.2480203602862403 0.28976088027074465 0.1830473656476021 103671116.77323173 136973417.57618374 3412765.173321343 0.07701993029658967 3.7891672636271567e-11 10.42145622342203 0.25164347649765195 MHVK(ub)SEASLHPVLMSEAPWNTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MHVKSEASLHPVLMSEAPWNTR 22 1 O96019;O96019-2;H7C5S0 O96019 ACTL6A Actin-like protein 6A 1 15138700.0 3712200.0 4810700.0 6615800.0 True False 3594358.2429555436 6731637.597469087 4882923.510254289 1.0 1.8728343538550134 1.358496616141187 21.77730277605142 -10.401046241215736 5.210936101947547 0.999534161863106 1.6156654849981225 0.656408388448757 0.20997750214279776 0.0011372083166304558 0.00013071232422152973 0.20345724115146188 0.06776994740642953 3.971492610150832e-11 10.401046241215736 0.6161313231350165 MHVK(ub)SEASLHPVLMSEAPWNTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MHVKSEASLHPVLMSEAPWNTR 22 1 O96019;O96019-2;H7C5S0 O96019 ACTL6A Actin-like protein 6A 1 15263900.0 3712200.0 6197500.0 5354200.0 True False 3086858.7783438466 6164112.837392559 6473738.464976288 1.0 1.9968885135392274 2.0971929491538197 21.557708051485697 -10.901296487971575 0.4231461876231819 1.0248767789532013e-21 2.1018087068888422 0.9995572695811383 0.010421168712424392 2.6107045233964756 0.2055134557630959 2.6120574210521075 0.024083734775744343 1.255172778755359e-11 10.901296487971575 2.1018087068888422 MHVQLSTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MHVQLSTSR 9 0 Q9BQ04;Q9BWF3;E9PB51 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 0 57346000.0 15476000.0 16387000.0 25483000.0 False True 20289185.86979721 13942123.476025712 22846263.61019666 1.0 0.6871701785126907 1.126031559709153 24.274207640436178 -6.715300158356288 1.7762061670613218 0.8087297294625735 1.1251748531728292 0.4902670396946819 0.13172131042703814 0.3645268213233244 2.244901100090297 0.058942980241039215 0.14879428708249043 1.926193183579256e-07 6.715300158356288 0.3164451237102557 MHVQLSTSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MHVQLSTSR 9 0 Q9BQ04;Q9BWF3;E9PB51 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 0 41851800.0 15618000.0 4568800.0 21665000.0 False True 15122215.13886096 6393145.665977251 15990286.563931692 1.0 0.4227651575692896 1.0574037214190908 23.850166148729258 -6.667329859833519 1.9471287111332969 0.6307031772735439 1.0547939447256558 0.2671466549344774 0.2453501258917465 0.4672796220699786 3.4129532858446043 0.10154219904980454 0.27221466722320686 2.1511472524892698e-07 6.667329859833519 0.42409076745211194 MHVQLSTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MHVQLSTSR 9 0 Q9BQ04;Q9BWF3;E9PB51 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 0 34144000.0 15476000.0 18668000.0 0.0 False True 21197895.4231745 17843186.0331793 0.0 1.0 0.8417432804990783 0.0 24.33741770195907 -7.189450556186911 0.9015701162423337 0.9913084078477145 1.8914572135400037e-19 0.9894416820257281 0.04509700194964564 0.09168760812480758 0.1415123726653665 0.03794778020676403 0.06661011251742445 6.46471589687068e-08 7.189450556186911 -0.9913084078477145 down MHVQLSTSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MHVQLSTSR 9 0 Q9BQ04;Q9BWF3;E9PB51 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 0 39688300.0 15618000.0 14444000.0 9626300.0 False True 12987058.994713156 14366187.30509046 11639114.823017664 1.0 1.1061925037022415 0.8962086664698897 23.630571424163534 -6.769266912995097 1.577733266278743 1.0609678245629024 0.8950735421192964 0.7275688266490056 0.044745370127235756 0.26762160981591687 1.3146867068073205 0.02235812904288596 0.0532472415090331 1.7011127003997692e-07 6.769266912995097 -0.16589428244360604 MHVQLSTSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MHVQLSTSR 9 0 Q9BQ04;Q9BWF3;E9PB51 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 0 58140000.0 12325000.0 29352000.0 16463000.0 False True 15954955.462071327 27718535.397518348 13466902.924644884 1.0 1.737299453039014 0.8440576945926845 23.92750124558097 -6.687428788355658 1.8752198862633287 1.4633341605301495 0.8472053444683397 0.3586011354573515 0.3119879894755758 0.4221983793477096 2.8763162637860953 0.1331877419757108 0.34800096905600225 2.0538617723512633e-07 6.687428788355658 -0.6161288160618098 MIAGQVLDINLAAEPK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MIAGQVLDINLAAEPK 16 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 75026500.0 27108000.0 33976500.0 13942000.0 False True 35538850.51424546 28907338.639359728 12499415.581107475 1.0 0.813401058871402 0.35171130749142226 25.0828936831072 -6.9556832609958965 0.4925171922276248 1.009877023767552 0.1355738258673027 0.9995750936329055 0.005616893448137296 0.08128073257396821 0.02711517527287284 0.0066837167873649095 0.03807919464072541 1.107431159567256e-07 6.9556832609958965 -0.8743031979002494 down MIAGQVLDINLAAEPK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MIAGQVLDINLAAEPK 16 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 138680000.0 54896500.0 41628800.0 42154700.0 False True 53153840.65632488 58251396.93132409 31113119.456107564 1.0 1.095901936944845 0.5853409475577632 25.663670602358298 -6.858130683126075 1.1950966537963055 1.0517992821538713 0.5614805742019581 0.9513261395636594 0.04888158857960817 0.1487481697496096 0.40475694323081973 0.031923640236415855 0.07437182028578926 1.386338604313673e-07 6.858130683126075 -0.49031870795191324 MIAGQVLDINLAAEPK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MIAGQVLDINLAAEPK 16 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 338574800.0 52777000.0 206751000.0 79046800.0 False True 80066567.51552762 169854668.69706407 63423165.33255677 1.0 2.121418139526507 0.7921304397151391 26.254696622848286 -6.683052606628355 1.8909238084272035 1.7075822247788908 0.7970580783789136 0.33816560156988473 0.4749703756737382 0.4318015689730391 2.9876037821657464 0.2013543598679658 0.5290136457220429 2.0746621958330523e-07 6.683052606628355 -0.9105241463999771 MIAGQVLDINLAAEPK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MIAGQVLDINLAAEPK 16 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 89858200.0 27108000.0 23089500.0 39660700.0 False True 37130560.166154966 22069329.543234035 30293659.497756254 1.0 0.5943710368083954 0.8158686365677121 25.146103744630093 -10.088961161191257 5.153090598943279 1.0000059563455226 0.7051198366874598 0.7026599560111123 0.09042601644566002 6.187962044189405e-06 1.0940399328618988e-06 0.08755638133637027 0.029184871312862397 8.147771460075858e-11 10.088961161191257 -0.2948861196580628 MIAGQVLDINLAAEPK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MIAGQVLDINLAAEPK 16 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 98143900.0 54896500.0 22428100.0 20819300.0 False True 45648872.07730002 22307275.373670723 25172519.372432988 1.0 0.4886708993794294 0.5514379266547227 25.444075877792574 -10.283212635106024 5.605228726540647 1.0000460717675357 0.5200544130176944 0.9873350075099034 0.02562453158266832 1.4754589633016869e-05 1.8868300679855527e-06 0.0248132189076523 0.008270282006165497 5.209395912006509e-11 10.283212635106024 -0.4799916587498413 MIAGQVLDINLAAEPK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MIAGQVLDINLAAEPK 16 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 0 192609500.0 52777000.0 83798200.0 56034300.0 False True 68320866.8902019 79134756.50546195 45836632.360470675 1.0 1.1582809192488583 0.6709023823443939 26.025822944940735 -6.819258316519815 1.3750615567042197 1.085376978483736 0.6604289857989645 0.88267419974511 0.06953469276751319 0.1944462047944694 0.7226251067941437 0.03973989425970984 0.09161350509961036 1.5161483006205947e-07 6.819258316519815 -0.42494799268477146 MIAGQVLDINLAAEPK(ub)VNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MIAGQVLDINLAAEPKVNR 19 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 6737400.0 2479600.0 3205100.0 1052700.0 True False 3250779.6124805594 2726911.573381946 943776.702211436 1.0 0.8388484912704164 0.290323188501626 21.632354320751105 -6.948582886462186 0.5741905187302789 1.006709613410385 0.09560052250233954 0.9990853324565344 0.009187085482751572 0.08405982434150651 0.0383562032711531 0.009687270867957532 0.045751043149808795 1.1256856077679711e-07 6.948582886462186 -0.9111090909080455 down MIAGQVLDINLAAEPK(ub)VNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MIAGQVLDINLAAEPKVNR 19 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 24050300.0 8751800.0 6666600.0 8631900.0 True False 8473978.899493111 9328608.145859728 6370946.438550745 1.0 1.1008533602104835 0.7518246757649865 23.01460810566882 -6.829420948362837 1.3305550714415955 1.0539106333466315 0.7425470274201192 0.9047015588485767 0.045274713757962395 0.18152620083465248 0.6287296053946738 0.026718655525169062 0.061486757782932874 1.4810818218692182e-07 6.829420948362837 -0.31136360592651224 MIAGQVLDINLAAEPK(ub)VNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MIAGQVLDINLAAEPKVNR 19 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 73884000.0 10830000.0 19002000.0 44052000.0 True False 16429901.779054567 15610944.636696378 35345102.89132253 1.0 0.9501544711970082 2.151266840583414 23.969820519831572 -6.8972183121365065 0.9786945780317932 0.9461796964725058 2.2704537976037202 0.9851305675544746 0.06765666233799392 0.11348160718300496 0.1891961262208725 0.05210712095956303 0.13377608664816512 1.2670147998732048e-07 6.8972183121365065 1.3242741011312145 up MIAGQVLDINLAAEPK(ub)VNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MIAGQVLDINLAAEPKVNR 19 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 10171900.0 2479600.0 3240100.0 4452200.0 True False 3396375.1286704224 3096941.6684221285 3400682.055937246 1.0 0.9118373416055744 1.0012680952791306 21.695564382273997 -9.951551508082739 4.392831158614011 1.000000942826433 0.9565527185402676 0.23936743715946573 0.03650995234963739 23608456.198867388 0.07055963893414964 257.2350876534138 0.01317439425330252 1.1180172179293939e-10 9.951551508082739 -0.04344822428616535 MIAGQVLDINLAAEPK(ub)VNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MIAGQVLDINLAAEPKVNR 19 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 23418700.0 8751800.0 10729000.0 3937900.0 True False 7277509.470478335 10671200.747460239 4761296.683207592 1.0 1.4663259169567036 0.6542480916750552 22.795013381103097 -6.750979581838959 1.6462788156639783 1.2738803199979685 0.6525177547788559 0.6531640333691178 0.19596293409095403 0.29833329865120195 1.5911338990271862 0.09402122145372993 0.22801853061465888 1.7742728955768073e-07 6.750979581838959 -0.6213625652191126 MIAGQVLDINLAAEPK(ub)VNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MIAGQVLDINLAAEPKVNR 19 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 60916000.0 10830000.0 17658000.0 32428000.0 True False 14019648.491215596 16675316.7773705 26526436.739378277 1.0 1.1894247411280594 1.8920900018284452 23.74094684192402 -6.946609670782867 0.5949123906180669 0.9919885384335616 2.125182284992966 0.9989075624055719 0.01268404684438313 0.0848765833063338 0.04182339938090389 0.013084360445117226 0.058954234578946656 1.1308117935457334e-07 6.946609670782867 1.1331937465594042 MIAILTENYGGKWPFWLSPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MIAILTENYGGKWPFWLSPR 20 1 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 34225600.0 11506000.0 8721600.0 13998000.0 False True 17455443.20127442 7165162.337828179 11231289.164458655 1.0 0.4104829797335109 0.6434261814468657 24.057173652220122 -10.25365580378928 5.579763309294342 1.0000323950667667 0.5269545805901822 0.8461183673226766 0.0950986638747073 3.8326684473593844e-05 5.126555928018651e-06 0.09208517546288385 0.03069296178610239 5.576275165545273e-11 10.25365580378928 -0.4730778144765845 MIAILTENYGGKWPFWLSPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MIAILTENYGGKWPFWLSPR 20 1 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 30548300.0 11506000.0 10069000.0 8973300.0 False True 14894743.817167753 9508651.298637643 7340251.473833199 1.0 0.6383897175645228 0.49280817205951466 23.82829997431257 -13.999999999998431 0.12537309412815584 2.7189299434198366 0.2764235272693564 0.9996670369112395 0.0038908445320752607 11.946354437858025 0.10962686962980539 5.083538025557519 0.19216941426132458 1.0000000000036117e-14 13.999999999998431 -2.44250641615048 MIAPEGSLVFHEK(ub)AWNAYPYCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MIAPEGSLVFHEKAWNAYPYCR 22 1 P48739;P48739-2;P48739-3;A0A0A0MSW4;B3KYB6;B3KYB7 P48739 PITPNB Phosphatidylinositol transfer protein beta isoform 1 22865200.0 14342000.0 5443900.0 3079300.0 True False 13886721.060413875 7617677.659563471 2272738.952980144 1.0 0.5485584124879395 0.16366274969394454 23.727202653860466 -7.892341290047229 0.36256865414240014 1.0730547861361677 1.4144953910779284e-19 0.9984776620899593 0.013335800329918978 0.10740700805475882 0.0681594946239972 0.042226026445578914 0.08260127694881561 1.2813232598227724e-08 7.892341290047229 -1.0730547861361677 down MIAPEGSLVFHEK(ub)AWNAYPYCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MIAPEGSLVFHEKAWNAYPYCR 22 1 P48739;P48739-2;P48739-3;A0A0A0MSW4;B3KYB6;B3KYB7 P48739 PITPNB Phosphatidylinositol transfer protein beta isoform 1 92104100.0 38278100.0 35687000.0 18139000.0 True False 58070676.20395473 29318376.026196312 14553818.69939387 1.0 0.5048740249420356 0.2506225112357608 25.7913064978115 -9.384935287513194 0.19836320611593591 1.4775355810721296 2.1665817976227222e-19 0.9995201390294484 0.006816087536684966 0.806800449304986 0.07551406796673903 0.37732604451161156 0.14376101790874857 4.1215892867841544e-10 9.384935287513194 -1.4775355810721296 MIAPEGSLVFHEK(ub)AWNAYPYCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MIAPEGSLVFHEKAWNAYPYCR 22 1 P48739;P48739-2;P48739-3;A0A0A0MSW4;B3KYB6;B3KYB7 P48739 PITPNB Phosphatidylinositol transfer protein beta isoform 1 13868000.0 3478600.0 5512500.0 4876900.0 True False 4764732.425630311 5268939.522600217 3725076.6629083045 1.0 1.1058206530670411 0.7818018579323531 22.18396376791791 -6.818743214299049 1.3773158077642773 1.0571096667976114 0.7749175560866307 0.8814700923951864 0.04644566467166738 0.1951164745986792 0.7276368260507428 0.026501974666910396 0.06110383400686306 1.5179476204702367e-07 6.818743214299049 -0.2821921107109807 MIAPEGSLVFHEK(ub)AWNAYPYCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MIAPEGSLVFHEKAWNAYPYCR 22 1 P48739;P48739-2;P48739-3;A0A0A0MSW4;B3KYB6;B3KYB7 P48739 PITPNB Phosphatidylinositol transfer protein beta isoform 1 84965100.0 38278100.0 38587000.0 8100000.0 True False 49551755.024155185 36439599.52930092 6625883.113018498 1.0 0.7353846399897959 0.13371641649803429 25.56243281990395 -7.231755135118756 0.5808865860130233 1.0029198704796185 9.863341068330499e-28 0.9979248508010129 0.01651197540965781 0.09138230606454917 0.05503353563268689 0.016296622732073992 0.054458164445977196 5.8646873542116285e-08 7.231755135118756 -1.0029198704796185 down MIEAVQNHIGSLNWGYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MIEAVQNHIGSLNWGYR 17 0 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9;E9PKD3 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 21656300.0 6426400.0 10181000.0 5048900.0 False True 8425072.633346125 8662034.485227179 4526488.260468627 1.0 1.0281257933543704 0.5372640044137963 23.006257693282357 -6.893316106430525 1.0025398862916992 1.0243163036029193 0.49219375886240935 0.9829379525368778 0.029397507456820057 0.11649455559514169 0.2064519166700694 0.022239283442253427 0.056148547408407225 1.2784504299956795e-07 6.893316106430525 -0.5321225447405099 MIEAVQNHIGSLNWGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MIEAVQNHIGSLNWGYR 17 0 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9;E9PKD3 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 24392200.0 9633000.0 4958500.0 9800700.0 False True 9327205.687837614 6938454.908235906 7233602.655302341 1.0 0.7438942744967483 0.7755380225756932 23.153013502050918 -10.005386978705364 7.077599350241598 1.0000000219407656 0.7597161486380402 0.9871596922830066 0.01291850605709903 4.470905400214662e-09 6.188708341643218e-10 0.0125082909157765 0.0041694299014185835 9.87672635365171e-11 10.005386978705364 -0.2402838733027255 MIEAVQNHIGSLNWGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MIEAVQNHIGSLNWGYR 17 0 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9;E9PKD3 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 27688100.0 6426400.0 9437700.0 11824000.0 False True 8802413.746929985 9020711.207699616 9031414.722923946 1.0 1.0247997273299914 1.0260157023491232 23.06946775480525 -13.999997968633638 0.4302413772461774 0.49144040390350263 1.0260399552465589 0.9998759871011889 0.00013337025639976872 31.817300921492972 0.22037489215188272 15.263352137270093 0.00028780624426817436 1.000004677404843e-14 13.999997968633638 0.5345995513430563 MIEAVQNHIGSLNWGYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MIEAVQNHIGSLNWGYR 17 0 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9;E9PKD3 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 20327900.0 9633000.0 5258800.0 5436100.0 False True 8010266.314257396 5230469.80060993 6572763.3763134675 1.0 0.6529707746795219 0.8205424287348185 22.933418777485194 -10.10394153255124 4.869843541900172 1.00001139443632 0.7367566017054025 0.7669231048498476 0.06841084130437818 8.463564012136198e-06 1.5573423698723143e-06 0.06624137857003334 0.02207950408845535 7.87151753871382e-11 10.10394153255124 -0.26325479273091756 MIEDLELSNK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 MIEDLELSNKR 11 1 H0Y8C9;H0Y8D6;J3QSS3;A0A087WXK5;Q9BZC7-2;Q9BZC7;Q9BZC7-3 H0Y8C9 ABCA2 ATP-binding cassette sub-family A member 2 1 48372000.0 19680000.0 12879000.0 15813000.0 True False 25800670.58139112 10957503.40194881 14176822.449006796 1.0 0.42469839562433587 0.5494749605164104 24.620905227219563 -9.84096616571723 6.5798101994784535 1.0000000121289 0.4870866780706584 0.9575010106620298 0.05093981930730406 9.036719314099472e-09 1.6754869644259538e-09 0.04932226869388682 0.016440755986309813 1.442227705794407e-10 9.84096616571723 -0.5129133340582417 MIEDLELSNK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 MIEDLELSNKR 11 1 H0Y8C9;H0Y8D6;J3QSS3;A0A087WXK5;Q9BZC7-2;Q9BZC7;Q9BZC7-3 H0Y8C9 ABCA2 ATP-binding cassette sub-family A member 2 1 72297000.0 15998000.0 25371000.0 30928000.0 True False 15490152.246862449 35501772.60801714 22827028.979888264 1.0 2.2918930713032903 1.4736478128878243 23.88484798811397 -10.080855704607275 4.757108163792419 0.9999657897558059 1.8827704421097666 0.6081370766233085 0.33404722797898373 232084992.49307853 5.177951920722903 95188.02343827579 0.11435325126492037 8.301265332497763e-11 10.080855704607275 0.8828046523539608 MIEDLELSNK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MIEDLELSNKR 11 1 H0Y8C9;H0Y8D6;J3QSS3;A0A087WXK5;Q9BZC7-2;Q9BZC7;Q9BZC7-3 H0Y8C9 ABCA2 ATP-binding cassette sub-family A member 2 1 49883000.0 19680000.0 11759000.0 18444000.0 True False 26956227.83200271 11239448.498187024 14087907.06610361 1.0 0.41695182902570055 0.5226216054376236 24.684115288742454 -9.966217477433371 5.672667919278684 1.0000005939511116 0.4697867172336105 0.971072345112551 0.04313950557545166 3.9538852119034686e-07 7.197780255609085e-08 0.04176970392211906 0.013923215554547765 1.0808925476802579e-10 9.966217477433371 -0.5302138767175011 MIFVGIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MIFVGIK 7 0 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 0 4077890.0 1307200.0 812690.0 1958000.0 False True 1713751.8589428074 691439.819840808 1755404.9424622327 1.0 0.40346554037721005 1.024305201072179 20.70872680025128 -10.958920221567976 12.829063463925491 1.0850207593748398 0.7138853707246949 0.220685071046534 0.2534567301308858 0.10972226078281742 0.0003513397883989665 0.04368763734174032 0.08180280789842571 1.099207741643541e-11 10.958920221567976 -0.37113538865014484 MIFVGIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MIFVGIK 7 0 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 0 3864860.0 1307200.0 922560.0 1635100.0 False True 1790507.1657517238 881798.2487020516 1248923.0559415538 1.0 0.49248518272856995 0.6975247459661563 20.771936861774172 -10.206792721513725 5.453893642948964 1.0000191153197078 0.5950049643473203 0.8387593386869459 0.0837070511693541 1.9456802322042193e-05 2.829860171564114e-06 0.08105282399544304 0.027016334594897978 6.211654310641332e-11 10.206792721513725 -0.40501415097238747 MIFVGIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MIFVGIK 7 0 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 0 3160150.0 1878160.0 537780.0 744210.0 False True 1561773.256595626 534882.872399028 899820.8701617421 1.0 0.34248433320274213 0.5761533349105897 20.574753582771933 -10.187613757500635 5.378033311528009 1.0000231153762926 0.45931883405662505 0.8771302246035566 0.09539497048200543 2.6440590321332782e-05 3.994005041092543e-06 0.09236972411215173 0.03078859433234144 6.492115572132965e-11 10.187613757500635 -0.5407042813196676 MIGGLFIYNHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MIGGLFIYNHK 11 0 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2;C9JJ47;C9JTK4;C9JGT8;C9JJD3;C9JPV8 E9PFW3 AP2M1 AP-2 complex subunit mu 0 18529500.0 5627100.0 5649900.0 7252500.0 False True 7377182.59291392 4806956.943137708 6502080.870892409 1.0 0.6515979349291128 0.8813772451745899 22.814638513618522 -10.537610052820034 5.044548092746997 1.0010858295083707 0.766487590051847 0.5793032589985254 0.0938070105916968 0.0011507117968103222 0.00010547557239545215 0.09123607126648996 0.030276082481593216 2.8999462418482242e-11 10.537610052820034 -0.2345982394565237 MIGGLFIYNHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MIGGLFIYNHK 11 0 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2;C9JJ47;C9JTK4;C9JGT8;C9JJD3;C9JPV8 E9PFW3 AP2M1 AP-2 complex subunit mu 0 14760900.0 4341900.0 3542700.0 6876300.0 False True 4204068.761135898 4957318.584936442 5075190.745421798 1.0 1.179171623157996 1.2072092617368446 22.00335483532705 -13.481827583374864 0.2675102545535247 2.722230060350425e-12 1.216908914996252 0.9995489307764394 0.0019494070112774226 11.24511259627131 0.16183759059993988 6.05752336910053 0.011798638064413359 3.29740594514105e-14 13.481827583374864 1.2169089149935297 MIGGLFIYNHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MIGGLFIYNHK 11 0 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2;C9JJ47;C9JTK4;C9JGT8;C9JJD3;C9JPV8 E9PFW3 AP2M1 AP-2 complex subunit mu 0 24890900.0 5627100.0 7724800.0 11539000.0 False True 7707590.936659676 7383492.793502442 8813725.853164697 1.0 0.957950785683796 1.1435124055746009 22.877848575141414 -6.847176528020288 1.2488293500055097 0.9776055786377548 1.150528274984283 0.9360653334638984 0.020086758830166574 0.1605942935797967 0.4834216567578208 0.012595449743336108 0.029095604300008557 1.4217507695015045e-07 6.847176528020288 0.17292269634652813 MIHILLYYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MIHILLYYK 9 0 B1AJY7;O75832;B1AJY5 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 26526900.0 7355500.0 11488600.0 7682800.0 False True 9643131.730763325 9774545.662212044 6887857.554621469 1.0 1.0136277233494058 0.7142759994295177 23.201070325603215 -6.896236661840022 0.9847753168793426 1.0137633731054019 0.6851511854967122 0.9845984724440379 0.01712816504644496 0.11422787172492015 0.19346376274819238 0.013131866416105396 0.03356454784019019 1.2698819147636292e-07 6.896236661840022 -0.3286121876086897 MIHILLYYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MIHILLYYK 9 0 B1AJY7;O75832;B1AJY5 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 64680800.0 36022000.0 12747500.0 15911300.0 False True 34878501.3274459 17837643.227334317 11743653.201231768 1.0 0.511422295925825 0.33670177198785445 25.055834715395395 -13.999999999999998 0.14318608250404224 3.34125346069035 0.12855629304665533 0.999590542758427 0.005680246131919279 11.938578075368167 0.11877825474024083 7.796878622915963 0.18650598482687222 1.0000000000000041e-14 13.999999999999998 -3.2126971676436944 MIHILLYYK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MIHILLYYK 9 0 B1AJY7;O75832;B1AJY5 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 835005700.0 234060500.0 274410800.0 326534400.0 False True 355086890.61462677 225440048.75863343 261994732.71488857 1.0 0.6348869944717331 0.7378327379571711 28.403596857857156 -10.240563913480234 7.933057331016605 1.0000002963340908 0.6863598662144529 0.9252400148275621 0.04202742378846141 2.2027155509053086e-07 2.1019938970652855e-08 0.040692916910755064 0.013564292701392705 5.746932371865923e-11 10.240563913480234 -0.31364043011963794 MIHILLYYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MIHILLYYK 9 0 B1AJY7;O75832;B1AJY5 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 60981500.0 7355500.0 25731000.0 27895000.0 False True 10075027.124913404 24594119.338961657 21306775.515558496 1.0 2.441097084309145 2.1148107346402436 23.264280387126107 -10.519754570065878 5.138326282719017 0.9956463105174365 2.277953909474706 0.9533879348728191 0.13320584445408237 0.006648453321839161 0.0006213865375427617 0.1290700219929668 0.0429920014323379 3.021658847830613e-11 10.519754570065878 1.2823075989572694 MIHILLYYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MIHILLYYK 9 0 B1AJY7;O75832;B1AJY5 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 78864000.0 36022000.0 19819000.0 23023000.0 False True 29953889.04517594 19712231.11323649 27837002.85367543 1.0 0.6580858693676418 0.9293285026091984 24.83623999082967 -9.878760056102163 6.117541243605807 1.0000000285267634 0.7937071859883443 0.43542461194906146 0.11073434132205248 4.301970141827446e-08 7.834883481340484e-09 0.10721807932731707 0.035739354982756745 1.3220258401505982e-10 9.878760056102163 -0.20629284253841906 MIHILLYYK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MIHILLYYK 9 0 B1AJY7;O75832;B1AJY5 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 718571800.0 234060500.0 277774000.0 206737300.0 False True 302995931.2722228 262315632.71703014 169113232.7038319 1.0 0.8657397860612063 0.5581369756146801 28.174723179949606 -6.9573032251220175 0.47190656078225457 1.0079759171063098 0.40325005466011615 0.9996567352028147 0.0034268043046340457 0.08067889325257986 0.024800181556729955 0.004268495345883088 0.025384857086376875 1.1033080194411481e-07 6.9573032251220175 -0.6047258624461938 MIIEEAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 MIIEEAKR 8 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 4300400.0 1094800.0 1577000.0 1628600.0 True False 1435293.4020582805 1341717.7470978543 1460088.0946343185 1.0 0.934803814449203 1.0172749993419332 20.452914251470553 -6.696024769325513 1.8453769996965246 0.9593579463370254 1.0170094440069506 0.39857473837459145 0.027540789934872134 0.40385531583541795 2.670974199304605 0.011919908532974756 0.030802403599326903 2.0136094034363597e-07 6.696024769325513 0.05765149766992517 MIIEEAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 MIIEEAKR 8 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 7638000.0 1792300.0 2538500.0 3307200.0 True False 1735404.4175554174 3552136.2881026184 2440945.1061266954 1.0 2.0468636890450846 1.4065569278457526 20.726840476054406 -10.101985196809002 4.845282823931893 0.9999676258285425 1.7267103084510376 0.632008537724864 0.2614041406514709 9.142749903507028e-05 1.6944794164578726e-05 0.2531147140979077 0.08436782361164051 7.907055792200615e-11 10.101985196809002 0.7267426826224951 MIIEEAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 MIIEEAKR 8 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 15672200.0 5962900.0 4752800.0 4956500.0 True False 9046155.246382698 3904625.706204112 3976845.602488871 1.0 0.43163372724179827 0.43961721794229647 23.108873324442797 -10.750516266400105 10.685803401150462 1.001217960699433 0.43562547259237594 0.9998499457525692 0.003259246430412537 9.469043341647775e-05 2.210751151943117e-06 0.0031597236972210592 0.0010519172621811408 1.7761667411250886e-11 10.750516266400105 -0.565592488107057 MIIEEAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MIIEEAKR 8 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 5126700.0 1094800.0 2068200.0 1963700.0 True False 1499577.1458575472 1976820.0853771926 1499914.5036709874 1.0 1.31825167570604 1.0002249686282378 20.516124312993444 -10.786019299322158 8.02548276798384 0.9969468427599886 1.1592383221671796 0.2505305411934632 0.1298338594863645 0.007205857268033038 0.00019212698136250372 0.12771708949936683 0.04190369796371028 1.6367437856487565e-11 10.786019299322158 0.16229147940719102 MIIEEAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MIIEEAKR 8 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 17125400.0 5962900.0 5534900.0 5627600.0 True False 7719091.59633145 5226877.949431872 4603434.54405221 1.0 0.6771364070761876 0.5963699855874262 22.879999646535246 -13.999999999999998 0.19459287348735144 2.7590938461230197 0.5410307898774114 0.9994875317311732 0.00394761086281253 12.429096764319613 0.13988893463811405 8.303753377156799 0.05358098207082074 1.0000000000000041e-14 13.999999999999998 -2.218063056245608 MIK(ub)SELEDFELDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MIKSELEDFELDK 13 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 28744200.0 7648900.0 12984000.0 8111300.0 True False 10027781.972052975 11046837.811235586 7272020.48508371 1.0 1.1016232544766809 0.7251873350807326 23.257499198198715 -6.834812237972357 1.306120327505503 1.0541500469029805 0.7140142224997236 0.9151786973197442 0.04630978544065461 0.17495285875138847 0.5819632822281072 0.02782225389992529 0.06404029633417273 1.4628094659510412e-07 6.834812237972357 -0.34013582440325696 MIK(ub)SELEDFELDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MIKSELEDFELDK 13 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 48774200.0 12220000.0 13375500.0 23178700.0 True False 11832082.788889803 18716406.90231105 17107503.12390508 1.0 1.5818353569910406 1.445857287270576 23.49620071631008 -10.06555170348427 4.565863075556037 0.9999748554133127 1.513846322100647 0.9500998601499179 0.05551281460311349 38509920.32859209 0.1436567563848353 11261.10307877951 0.01900351297792091 8.599006881800014e-11 10.06555170348427 0.5138714666873344 MIK(ub)SELEDFELDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MIKSELEDFELDK 13 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 98229100.0 21810100.0 25267000.0 51152000.0 True False 33087516.23188905 20757906.43802794 41041784.77928191 1.0 0.627363694891728 1.2404008959647053 24.979783661681665 -6.742152332367255 1.6786271086462876 0.7788400513133963 1.240945381381732 0.6146460881050397 0.1565608271467436 0.31393585165915733 1.7376947093470836 0.07375642823129785 0.1805790524264283 1.8107048615730292e-07 6.742152332367255 0.46210533006833565 MIK(ub)SELEDFELDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MIKSELEDFELDK 13 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 31159100.0 7648900.0 13790000.0 9720200.0 True False 10476905.033750283 13180712.202568166 7424488.953802895 1.0 1.2580730817076078 0.7086528826867915 23.320709259721607 -6.778970539956562 1.5398412686368919 1.1463221978551186 0.7044370777986081 0.7637467038539476 0.10908957607635217 0.25217563373182605 1.1809651675737234 0.05580241860574504 0.13178624634438463 1.6635254905583285e-07 6.778970539956562 -0.4418851200565105 MIK(ub)SELEDFELDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MIKSELEDFELDK 13 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 47426300.0 12220000.0 11826000.0 23380300.0 True False 10161471.437789394 11762290.990722788 28269012.63170688 1.0 1.1575381639100144 2.781980228432029 23.276605991744358 -6.925700014565398 0.7812789052791651 0.9709680478994125 3.0816723917600237 0.9956236023745946 0.05328555391404414 0.0949326950665526 0.08907379856931733 0.047356847038905546 0.15060813863193084 1.1865880913765499e-07 6.925700014565398 2.1107043438606112 up MIK(ub)SELEDFELDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MIKSELEDFELDK 13 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 146287400.0 21810100.0 30067300.0 94410000.0 True False 28233604.391344562 28394028.3237191 77228348.72840446 1.0 1.005682020975817 2.735334378775952 24.750909983774115 -6.907620057998476 0.9117922005629583 0.9423327804462086 2.9478449924495593 0.9899919602065242 0.08170367407164628 0.10601283288685596 0.14746089851436123 0.06611452115013723 0.1796316938329163 1.2370291736703877e-07 6.907620057998476 2.005512212003351 up MIKPFFHSLSEK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MIKPFFHSLSEK 12 1 P10599 P10599 TXN Thioredoxin 0 116467000.0 27538100.0 25312000.0 63616900.0 False True 36102715.77933978 21535548.26540322 57034433.44439511 1.0 0.5965077086452094 1.579782357454498 25.105604030244127 -6.795300986038397 1.4751991147852366 0.7760287386952957 1.5918034090319861 0.8179970157373759 0.17216813992316188 0.22754724684993738 0.9780702771229274 0.09183928786063623 0.21420778407328572 1.602134652881416e-07 6.795300986038397 0.8157746703366905 MIKPFFHSLSEK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MIKPFFHSLSEK 12 1 P10599 P10599 TXN Thioredoxin 0 68742500.0 19365300.0 11938600.0 37438600.0 False True 18750559.151529275 16705745.238976534 27632307.52607487 1.0 0.8909465101265545 1.4736791208608417 24.160430282385942 -6.858323595682379 1.1941176827645124 0.9410717684744767 1.5010150858791433 0.9515720855510779 0.055664491447706556 0.14854438095079794 0.40343111152477185 0.03638060913421411 0.0847726495805963 1.3857229328155866e-07 6.858323595682379 0.5599433174046666 MIKPFFHSLSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MIKPFFHSLSEK 12 1 P10599 P10599 TXN Thioredoxin 0 23399300.0 7145400.0 13674000.0 2579900.0 False True 10840094.198712535 11233767.86455036 2069981.6341896623 1.0 1.0363164432542091 0.19095605593865703 23.36987395775064 -6.8968630142547775 0.9809002774494251 1.0382356548716365 0.1076678605902895 0.9849395153349816 0.047889307353841726 0.11375087228504832 0.19073433162137934 0.036822277478500795 0.09438158838708363 1.2680517733679302e-07 6.8968630142547775 -0.930567794281347 down MIKPFFHSLSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MIKPFFHSLSEK 12 1 P10599 P10599 TXN Thioredoxin 0 95541100.0 27538100.0 33020600.0 34982400.0 False True 37719679.75917043 31561640.70747804 26720277.605143342 1.0 0.836742011305246 0.7083908923868075 25.16881409176702 -6.973828453003204 0.1390517295939176 1.1742661216075165 0.3675214337963659 0.9999989537156476 0.0001219266612110451 0.07507895336062081 0.004207402443411091 0.0073272689355838375 0.016787834751508558 1.0621150114345681e-07 6.973828453003204 -0.8067446878111506 MIKPFFHSLSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MIKPFFHSLSEK 12 1 P10599 P10599 TXN Thioredoxin 0 63678500.0 19365300.0 12468000.0 31845200.0 False True 16103104.978250653 12400832.409295766 38503884.08443144 1.0 0.7700895216198808 2.3910844608189517 23.94083555782022 -6.870966273767935 1.1290353470022325 0.8691918557817305 2.4877513174603276 0.9656348668057534 0.13275528355153735 0.1359284318486226 0.3232617094079382 0.09120256368689003 0.21628523917692158 1.3459648742905677e-07 6.870966273767935 1.618559461678597 up MIKPFFHSLSEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MIKPFFHSLSEK 12 1 P10599 P10599 TXN Thioredoxin 0 34247500.0 7145400.0 22828800.0 4273300.0 False True 9249861.15689124 21558357.21187198 3495603.2477607303 1.0 2.3306681955772697 0.3779087262468227 23.14100027984309 -6.723219623458173 1.7475216891300096 1.8067574589868127 0.3803440422601261 0.5277487020117885 0.5597406641744134 0.34910504725904296 2.0851523032589863 0.2541479327230852 0.6356533217668054 1.8913868991861294e-07 6.723219623458173 -1.4264134167266866 MILELFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MILELFSK 8 0 Q5TA02;P78417-3;P78417;Q5TA01;P78417-2 Q5TA02 GSTO1 Glutathione S-transferase omega-1 0 9056200.0 2801600.0 3890100.0 2364500.0 False True 3672924.730732994 3309712.243491031 2119844.221885574 1.0 0.9011108275095314 0.5771542782099222 21.808497900539155 -6.949457322284149 0.5647690869512516 1.0041358569928283 0.45851954148547264 0.9991580112633534 0.005240279855998425 0.08370437419314655 0.036869737708554784 0.005585467013517781 0.02695836192758157 1.1234213618252201e-07 6.949457322284149 -0.5456163155073557 MILELFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MILELFSK 8 0 Q5TA02;P78417-3;P78417;Q5TA01;P78417-2 Q5TA02 GSTO1 Glutathione S-transferase omega-1 0 9552300.0 4503000.0 2608600.0 2440700.0 False True 4360054.729817583 3650227.5836692913 1801407.450569493 1.0 0.8371976522923166 0.4131616601622018 22.055914813945837 -6.954577430054065 0.5061050763117451 1.0080608701664235 0.22381845346771204 0.9995132557720584 0.005457360536991368 0.08169812041785421 0.028746213682222937 0.006328915643135888 0.03498848298113351 1.1102545711894593e-07 6.954577430054065 -0.7842424166987115 down MILELFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MILELFSK 8 0 Q5TA02;P78417-3;P78417;Q5TA01;P78417-2 Q5TA02 GSTO1 Glutathione S-transferase omega-1 0 13041600.0 2801600.0 3906300.0 6333700.0 False True 3837427.2303932295 3733706.749593327 4837810.506646091 1.0 0.9729713491428802 1.260691139190762 21.871707962062047 -6.883896752486352 1.0578703710401658 0.9822037157982711 1.2826651518682428 0.9766934118295886 0.01980550082161084 0.12423243904465744 0.2519247978570797 0.014368119937325794 0.035115337909286955 1.3064814491311379e-07 6.883896752486352 0.30046143606997167 MILFAFGSALAQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MILFAFGSALAQAR 14 0 Q9BZE1;A6NHR2;S4R369;H0Y4J2 Q9BZE1 MRPL37 39S ribosomal protein L37, mitochondrial 0 15235700.0 0.0 7103600.0 8132100.0 False True 0.0 5835907.079319873 6524786.870573945 0.0 MILFAFGSALAQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MILFAFGSALAQAR 14 0 Q9BZE1;A6NHR2;S4R369;H0Y4J2 Q9BZE1 MRPL37 39S ribosomal protein L37, mitochondrial 0 13317000.0 0.0 6776500.0 6540500.0 False True 0.0 6399381.817977757 5350196.111197226 0.0 MILIQDGSQNTNVDKPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MILIQDGSQNTNVDKPLR 18 1 A0A087WTP3;Q92945;M0R0I5;M0QYH3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 18618200.0 6129600.0 3076000.0 9412600.0 False True 5935019.203173406 4304262.84112809 6947157.688052766 1.0 0.7252314935774152 1.1705366823982941 22.50082126714051 -6.739777031570649 1.6873503324534789 0.8364692963395106 1.1707919854356132 0.6039558568640981 0.11544731472614789 0.318247472208552 1.7790170976791255 0.0541262396200413 0.13286178111025565 1.820635339774787e-07 6.739777031570649 0.33432268909610263 MILIQDGSQNTNVDKPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MILIQDGSQNTNVDKPLR 18 1 A0A087WTP3;Q92945;M0R0I5;M0QYH3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 7530900.0 6129600.0 0.0 1401300.0 False True 5097033.987321927 0.0 1694305.3511208508 1.0 0.0 0.3324100556000156 22.281226542574785 -10.509696308435327 6.179387482891371 1.0007785433106258 0.1662050278000315 0.8934921172581912 0.1357058369317041 0.0014567340977867803 0.00011558455006876633 0.13150306856386396 0.04379887053496907 3.0924571566541433e-11 10.509696308435327 -0.8345735155105942 MILLEVNNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MILLEVNNR 9 0 O15144;C9JTV5;G5E9J0;G5E9S7 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 9614000.0 2360700.0 4698100.0 2555200.0 False True 3094900.5610513175 3997161.793050367 2290812.4152091416 1.0 1.291531574020122 0.7401893437348331 21.561461625812893 -6.763038895057729 1.6009740264981578 1.1686968990836788 0.7378629634937091 0.7032661678781739 0.12267854912184559 0.2778445221043629 1.4042082168366274 0.060439839100255376 0.1448173276615495 1.7256833342847138e-07 6.763038895057729 -0.43083393558996974 MILLEVNNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MILLEVNNR 9 0 O15144;C9JTV5;G5E9J0;G5E9S7 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 9030300.0 5713400.0 3316900.0 0.0 False True 5532031.244357038 4641355.4674049895 0.0 1.0 0.8389966112609026 0.0 22.399377874032332 -7.193244132738761 0.8982908762494025 0.9911078565821537 1.3980407112503445e-19 0.9894084902660267 0.04511908861285266 0.09209049793312296 0.14118450503385244 0.03798449645016272 0.06667893040655656 6.408492306302179e-08 7.193244132738761 -0.9911078565821537 down MILLEVNNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MILLEVNNR 9 0 O15144;C9JTV5;G5E9J0;G5E9S7 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 62078000.0 15842000.0 25188000.0 21048000.0 False True 24033472.205335423 20693004.605257757 16887853.574333865 1.0 0.8610076991149002 0.7026805544387701 24.51854175926868 -6.969427719406329 0.2715120720963745 1.038644516741399 0.5202743378146744 0.9999775643351027 0.0005753090177786999 0.07648887315148697 0.009693013829156659 0.0030750974254581957 0.014694882853635008 1.0729322034622626e-07 6.969427719406329 -0.5183701789267245 MILLEVNNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MILLEVNNR 9 0 O15144;C9JTV5;G5E9J0;G5E9S7 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 15964300.0 2360700.0 5949500.0 7654100.0 False True 3233514.585518735 5686631.417634474 5846359.221137707 1.0 1.7586533993389113 1.8080509818389479 21.624671687335784 -11.198453291103544 0.46883448248774634 3.1663943328919354e-12 1.8073811861075024 0.999761436744337 0.0057121421320657515 3.2629152581936043 0.22947712584810387 3.430631043651862 0.010687130052551064 6.332084603839703e-12 11.198453291103544 1.807381186104336 MILLEVNNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MILLEVNNR 9 0 O15144;C9JTV5;G5E9J0;G5E9S7 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 55406000.0 15842000.0 23163000.0 16401000.0 False True 20507781.292505782 21873958.688086595 13416186.288471155 1.0 1.0666175134255045 0.6541997935863433 24.28966808136113 -6.865508626831075 1.1576760049233938 1.0368208518489435 0.6320302389932365 0.9599866500178917 0.03616027294536802 0.141229295484727 0.3566030139270563 0.024302578989171528 0.0571261013316055 1.3629859315691585e-07 6.865508626831075 -0.40479061285570694 MILNGVCVIWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MILNGVCVIWK 11 0 J3KS23 J3KS23 CBFB 0 3477500.0 810910.0 1938800.0 727790.0 False True 1063110.8628636114 1649538.5973832102 652485.2722546412 1.0 1.5516148456427095 0.6137509219848408 20.019860620533546 -6.747335356217705 1.6599472926372878 1.325392821392381 0.6122856065213917 0.6373424789688631 0.2317668354516703 0.3047079049676361 1.6511044313737173 0.11034179491211012 0.2686085372068446 1.7892237065618156e-07 6.747335356217705 -0.7131072148709892 MILNGVCVIWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MILNGVCVIWK 11 0 J3KS23 J3KS23 CBFB 0 7012210.0 810910.0 2526900.0 3674400.0 False True 1110725.3410187662 2415253.2026591375 2806582.396643414 1.0 2.1744828477973215 2.5268014449631573 20.083070682056437 -10.201411148110374 0.2776744404545283 4.935618694041991e-24 2.6738880677355024 0.999019071070039 0.02044377008526667 1.6840962228489482 0.1295583997595401 1.399860470967793 0.13866240330090404 6.289105091520283e-11 10.201411148110374 2.6738880677355024 MIMSFEMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MIMSFEMK 8 0 E7ET15;O15042-2;O15042;E7EW00;H0Y8D9 E7ET15 U2SURP U2 snRNP-associated SURP motif-containing protein 0 3643600.0 1079100.0 1429600.0 1134900.0 False True 1414710.5500192652 1216309.2525371548 1017471.4347295138 1.0 0.8597583813314967 0.7192082046151831 20.432075476962133 -6.971098028426187 0.2304571220927658 1.0568352625325241 0.51811317948958 0.9999897234857777 0.0003674330206598462 0.07594800143757877 0.007743366263924266 0.003599245801729181 0.013947062693006839 1.068813600677428e-07 6.971098028426187 -0.5387220830429441 MIMSFEMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MIMSFEMK 8 0 E7ET15;O15042-2;O15042;E7EW00;H0Y8D9 E7ET15 U2SURP U2 snRNP-associated SURP motif-containing protein 0 4052100.0 1079100.0 1489600.0 1483400.0 False True 1478072.4315810013 1423784.546551527 1133051.4715819836 1.0 0.9632711605537451 0.7665737127442595 20.495285538485025 -6.938285746491957 0.675322945861437 1.0022870324232007 0.7161027800619575 0.9979306334854133 0.004662023171818623 0.08855749088155394 0.058236722669290086 0.004481218819856839 0.01706118102781541 1.1526945863894912e-07 6.938285746491957 -0.28618425236124323 MININILSVCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MININILSVCK 11 0 A0A1B0GV93;Q53GQ0;E9PI21;A0A1B0GVY6 A0A1B0GV93 HSD17B12 Very-long-chain 3-oxoacyl-CoA reductase 0 9048300.0 2885300.0 3738500.0 2424500.0 False True 3782656.241284942 3180730.3725588624 2173635.9974462115 1.0 0.8408721727984435 0.5746321787643708 21.850968243007877 -6.96337870311819 0.38486540676676373 1.01731658775058 0.3886996866709336 0.9998757231510416 0.001956248721695613 0.07851552281742663 0.016827125464354723 0.0034494855962455273 0.022446102448478562 1.0879809643579523e-07 6.96337870311819 -0.6286169010796465 MININILSVCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MININILSVCK 11 0 A0A1B0GV93;Q53GQ0;E9PI21;A0A1B0GVY6 A0A1B0GV93 HSD17B12 Very-long-chain 3-oxoacyl-CoA reductase 0 13881200.0 2885300.0 4590900.0 6405000.0 False True 3952073.3823006744 4388058.857923872 4892270.915115684 1.0 1.1103181630117889 1.2378998165939115 21.91417830453077 -6.969218942050474 0.27620709813326805 0.9705781903425463 1.3815074436857964 0.9999756288827593 0.00047985010060397896 0.07655697849993667 0.009933964397645217 0.0024092853369003337 0.011767521292321273 1.0734481156114128e-07 6.969218942050474 0.41092925334325003 MINLSVPDTIDER ddPTM_RPMI8226_Bortezomib_1h_R1 2 MINLSVPDTIDER 13 0 P13796;Q5TBN3;P13797;A0A0A0MSQ0;P13797-2;P13797-3;U3KQI3 P13796;P13797 LCP1;PLS3 Plastin-2;Plastin-3 0 48298400.0 6508700.0 19593300.0 22196400.0 False True 8532968.730340457 16670056.014085205 19899729.450903308 1.0 1.9536056606901555 2.3320991884273936 23.024616330492908 -10.076121518044198 0.22089332452881377 1.894742082463073e-18 2.6065030108939546 0.9992774621911739 0.015065387477009059 1.5909230560535694 0.10238167319640608 1.152377251880536 0.20003743701865195 8.392251337411467e-11 10.076121518044198 2.6065030108939546 MINLSVPDTIDER ddPTM_RPMI8226_Bortezomib_2h_R1 2 MINLSVPDTIDER 13 0 P13796;Q5TBN3;P13797;A0A0A0MSQ0;P13797-2;P13797-3;U3KQI3 P13796;P13797 LCP1;PLS3 Plastin-2;Plastin-3 0 41313200.0 16821800.0 6581200.0 17910200.0 False True 16287801.16678779 9209107.480504602 13218981.325517159 1.0 0.5653990606959738 0.8115878374345449 23.957288519156243 -10.164515925491532 5.426179105413353 1.0000091197084866 0.6884934490651944 0.6809900827081707 0.10050614723514005 1.1088710764842149e-05 1.7072399816513654e-06 0.09731750537594587 0.03243821953606422 6.846743757587822e-11 10.164515925491532 -0.3115156706432922 MINLSVPDTIDER ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MINLSVPDTIDER 13 0 P13796;Q5TBN3;P13797;A0A0A0MSQ0;P13797-2;P13797-3;U3KQI3 P13796;P13797 LCP1;PLS3 Plastin-2;Plastin-3 0 62313900.0 6508700.0 31373600.0 24431600.0 False True 8915142.281003853 29987410.613378692 18661359.26459648 1.0 3.3636491340441155 2.093220576452224 23.0878263920158 -10.127304923928351 5.878748404378343 0.9999871974022594 2.728434855248232 0.7116489485445784 0.5186502867935812 8.702909287635878e-05 1.2920162030030084e-05 0.5021846845192849 0.16739366027140454 7.45924850757836e-11 10.127304923928351 1.7284476578459724 MINLSVPDTIDER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MINLSVPDTIDER 13 0 P13796;Q5TBN3;P13797;A0A0A0MSQ0;P13797-2;P13797-3;U3KQI3 P13796;P13797 LCP1;PLS3 Plastin-2;Plastin-3 0 20615500.0 13096000.0 4879600.0 2639900.0 False True 10889904.251169408 4853312.626275238 3191890.8844815055 1.0 0.4456708263301825 0.29310550495783705 23.376487933512422 -13.999999999999998 0.18102907562954457 3.8853011562716784 0.1731938304009559 0.9994969332736161 0.006812360410743912 12.218198366707687 0.13488716000094297 12.402911318917862 0.11292205780635085 1.0000000000000041e-14 13.999999999999998 -3.7121073258707225 MIPCDFLIPVQTQHPIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MIPCDFLIPVQTQHPIR 17 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;K7ESF4 P06744 GPI Glucose-6-phosphate isomerase 0 31337700.0 5815700.0 13515000.0 12007000.0 False True 7624439.019318914 11498614.681057388 10764630.81927682 1.0 1.50812599483346 1.411858733737819 22.862199762123836 -10.099073788643201 4.798772207052734 0.9999781521142354 1.4599923642902517 0.9681960851594438 0.03930094478580893 9.186871632770731e-06 1.7247411670211895e-06 0.03805478108511742 0.01268432538488191 7.960240907485181e-11 10.099073788643201 0.46001421217601635 MIPCDFLIPVQTQHPIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MIPCDFLIPVQTQHPIR 17 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;K7ESF4 P06744 GPI Glucose-6-phosphate isomerase 0 11905500.0 6231700.0 2474100.0 3199700.0 False True 6033878.094560125 3462021.0322610587 2361602.5810575676 1.0 0.5737638344702825 0.39139050276582205 22.524654118617843 -13.999999999997616 0.11590426933727875 3.03928105932986 0.08357396225239078 0.999713252427125 0.004318504542093649 11.981303959677186 0.10422456355674273 5.660908846522397 0.27315211751771307 1.000000000005489e-14 13.999999999997616 -2.955707097077469 MIPCDFLIPVQTQHPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MIPCDFLIPVQTQHPIR 17 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;K7ESF4 P06744 GPI Glucose-6-phosphate isomerase 0 30576700.0 5815700.0 13860000.0 10901000.0 False True 7965921.453383032 13247619.371109135 8326408.313142251 1.0 1.6630366554120402 1.0452536297111146 22.925409823646728 -10.233241552670652 5.594456485358192 0.9999818286465634 1.3541451425615487 0.3046654378170681 0.25220886412004206 5.71908668798668e-05 7.837972822255536e-06 0.24421270191532204 0.0814000608752276 5.844649169219294e-11 10.233241552670652 0.35416331391498534 MIPPGIHFLHYSSVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MIPPGIHFLHYSSVDK 16 0 A2A2Q9;Q9Y312 A2A2Q9 AAR2 Protein AAR2 homolog 0 6366280.0 1751600.0 759180.0 3855500.0 False True 1695996.416777366 1062324.5330714 2845628.8874792773 1.0 0.6263719206966057 1.6778507662689384 20.69370169116928 -6.810631674274179 1.4117457840985574 0.7965228837828883 1.6965364592470051 0.8614979736866305 0.1619679852167164 0.20594219417500556 0.8088183336827375 0.0902059666157469 0.20861857062413508 1.5465655277662873e-07 6.810631674274179 0.9000135754641169 MIQDGK(ub)GDVTITNDGATILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MIQDGKGDVTITNDGATILK 20 1 P50991 P50991 CCT4 T-complex protein 1 subunit delta 1 30245700.0 8255900.0 12584000.0 9405800.0 True False 10823564.85024934 10706516.2520478 8432578.04280452 1.0 0.9891857627481352 0.7790943334727893 23.3676724078065 -6.917574820511949 0.8425321367483296 1.0050529549867184 0.7470370667897076 0.9934800224193009 0.00821052213384283 0.09961957890431242 0.11316827347147819 0.00698482469284348 0.020461041092465968 1.2089968782981918e-07 6.917574820511949 -0.2580158881970108 MIQDGK(ub)GDVTITNDGATILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MIQDGKGDVTITNDGATILK 20 1 P50991 P50991 CCT4 T-complex protein 1 subunit delta 1 44323000.0 15000000.0 16041000.0 13282000.0 True False 14523833.21058489 22446254.952709902 9803045.74854099 1.0 1.5454773286952368 0.67496270484548 23.791918931874598 -6.737304148563746 1.6965209203633167 1.3255742894328382 0.6747464898510508 0.592742585979934 0.22920683919730764 0.32274418384740383 1.8228549070029225 0.10692557401391511 0.2631708424516903 1.8310316506028734e-07 6.737304148563746 -0.6508277995817874 MIQDGK(ub)GDVTITNDGATILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MIQDGKGDVTITNDGATILK 20 1 P50991 P50991 CCT4 T-complex protein 1 subunit delta 1 50887000.0 0.0 25682000.0 25205000.0 True False 0.0 21098846.445618156 20223220.702256046 0.0 MIQDGK(ub)GDVTITNDGATILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MIQDGKGDVTITNDGATILK 20 1 P50991 P50991 CCT4 T-complex protein 1 subunit delta 1 28549700.0 8255900.0 12867000.0 7426800.0 True False 11308329.3373085 12298493.394521013 5672742.799747257 1.0 1.0875605960595576 0.5016428714214852 23.43088246932939 -6.8688549728913495 1.1400541177352561 1.0492001126355919 0.46805528135527175 0.9635312397151892 0.04928002257471401 0.13796182980444913 0.33583515932016555 0.033567980186081786 0.07932417798269382 1.3525241459952322e-07 6.8688549728913495 -0.5811448312803201 MIQDGK(ub)GDVTITNDGATILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MIQDGKGDVTITNDGATILK 20 1 P50991 P50991 CCT4 T-complex protein 1 subunit delta 1 43894400.0 15000000.0 21169000.0 7725400.0 True False 12473164.612671128 21054958.395282477 9340745.421786226 1.0 1.6880205664802461 0.7488673253215333 23.572324207308874 -6.710303740701008 1.7938336585624721 1.4228346807327181 0.7510238154674976 0.46670997769742706 0.2899127368748994 0.3744479815221102 2.348898831611047 0.12859590007572233 0.32660901849478585 1.9484813770301262e-07 6.710303740701008 -0.6718108652652205 MIQDGK(ub)GDVTITNDGATILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MIQDGKGDVTITNDGATILK 20 1 P50991 P50991 CCT4 T-complex protein 1 subunit delta 1 45861000.0 0.0 23620000.0 22241000.0 True False 0.0 22305526.23635131 18193366.211931422 0.0 MISDAIPELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MISDAIPELK 10 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 7452700.0 3844500.0 1242000.0 2366200.0 False True 3722458.4518729015 1737937.0769444357 1746421.2355215847 1.0 0.4668788381157129 0.4691580196530865 21.827824315616724 -9.760562976518898 6.049555495099116 1.000000016898709 0.4680184288830455 0.9999862330837509 0.0009304719711446625 2.1318954982121605e-10 4.216374901638366e-11 0.0009009256502287074 0.0003003085366514152 1.7355495746732938e-10 9.760562976518898 -0.5319815880156635 MITAAYVPLPTYHNLFPDSMTATQLLVPSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MITAAYVPLPTYHNLFPDSMTATQLLVPSR 30 0 Q14498-3;Q14498-2;Q14498 Q14498-3 RBM39 RNA-binding protein 39 0 64684000.0 31530000.0 18244000.0 14910000.0 False True 40816206.54921769 17228705.362235084 12196532.989519233 1.0 0.4221045221696454 0.2988159366258646 25.28263876899903 -13.99999999999993 0.2171226312081676 4.443928275457594 0.23102246473953003 0.9994951785593539 0.006867514914264296 12.922932765556505 0.1476370780911526 19.05360778317053 0.06954940017377306 1.0000000000001595e-14 13.99999999999993 -4.212905810718064 MITSAAGIISLLDEDEPQLK(ub)EFALHK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MITSAAGIISLLDEDEPQLKEFALHK 26 1 Q99460;Q99460-2;C9J9M4;F8WCE3 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 147859300.0 49764000.0 60598300.0 37497000.0 True False 75495626.23572218 49784059.908321105 30085701.51448109 1.0 0.6594297231587812 0.39850919867256457 26.169889729963 -7.661494937530861 0.19006608920887288 1.231685411187161 3.012028341222746e-11 0.9999357199402459 0.0019744911421812777 0.1330218327261897 0.022456887197298922 0.04657953226052928 0.08023190864002057 2.1802438116296958e-08 7.661494937530861 -1.2316854111570406 down MITSAAGIISLLDEDEPQLK(ub)EFALHK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MITSAAGIISLLDEDEPQLKEFALHK 26 1 Q99460;Q99460-2;C9J9M4;F8WCE3 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 118678200.0 49764000.0 49687500.0 19226700.0 True False 64420478.99509259 46922346.94617714 15727637.88260159 1.0 0.7283762505049299 0.24414034369101303 25.94101605205545 -7.099271193824855 0.43798753076970615 1.0190481951997206 4.319958967842035e-14 0.9997246111495938 0.00518789557182785 0.07628419833303114 0.023204976438909238 0.007227710873581761 0.038884198182937674 7.95662346404594e-08 7.099271193824855 -1.0190481951996773 down MITSLSK(ub)DQQIGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MITSLSKDQQIGEK 14 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 17371200.0 6089400.0 6668200.0 4613600.0 True False 7983262.369833479 5673330.552440022 4136228.928776174 1.0 0.7106531502557094 0.5181126132601916 22.928546995341897 -8.300135055472646 0.1167772790181441 1.4836684629378207 1.0229593225051796e-12 0.9999706007203861 0.0010738253375229972 0.09003701603329682 0.02481783964252536 0.14794468048782058 0.14660847632206483 5.010314002977588e-09 8.300135055472646 -1.4836684629367978 MITSLSK(ub)DQQIGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MITSLSKDQQIGEK 14 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 23228800.0 9315000.0 10388000.0 3525800.0 True False 14131536.017718691 8534180.238185542 2828924.084586963 1.0 0.6039103058213234 0.200185180226689 23.752414951164884 -7.618514767716609 0.3652242375058972 1.0566706171764608 2.2369114433026506e-19 0.9990246619502983 0.010197599048673022 0.12264515312269342 0.049950911442858716 0.025515430036226555 0.07251761493951976 2.40705066849027e-08 7.618514767716609 -1.0566706171764608 down MITSLSK(ub)DQQIGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MITSLSKDQQIGEK 14 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 15735900.0 6089400.0 4583900.0 5062600.0 True False 8340815.739847413 4381368.1410697745 3866918.1475198525 1.0 0.5252925226651665 0.4636139039789643 22.991757056864788 -13.999999999999998 0.2876841239949844 5.037641447990987 0.4464106197601499 0.9996222819757 0.0046574623405332026 15.829523477673153 0.1700428036624627 37.77468238895444 0.023540802499172574 1.0000000000000041e-14 13.999999999999998 -4.591230828230837 MITSLSK(ub)DQQIGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MITSLSKDQQIGEK 14 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 16970200.0 4141800.0 6569600.0 6258800.0 True False 3444090.21285075 6534208.260836496 7567486.14257846 1.0 1.8972233179188378 2.1972380730162944 21.715691501817307 -10.43200488321176 0.23885657875499083 4.1762138011986467e-16 2.3714317233526923 0.9991928859213464 0.014450229274036335 2.0596471356710833 0.11777256497879882 1.3933124197392266 0.14456107931513945 3.698240214516685e-11 10.43200488321176 2.371431723352692 MITSLSK(ub)DQQIGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MITSLSKDQQIGEK 14 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 79557200.0 9315000.0 14212200.0 56030000.0 True False 12058451.12610096 13421278.57647213 45833114.91634896 1.0 1.1130184495603486 3.8009122761331677 23.523541273257333 -6.91573441323801 0.8557638197003983 0.9310950354147126 4.194512897914729 0.9929115670323233 0.10899153663899733 0.10074748168194632 0.11910047604501932 0.09184426106010694 0.26483435138771183 1.2141311085091655e-07 6.91573441323801 3.2634178625000163 up MIVLGFSNPINWVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MIVLGFSNPINWVR 14 0 H7C0V0;Q8WWC4 H7C0V0 C2orf47 Uncharacterized protein C2orf47, mitochondrial 0 55149000.0 17297000.0 19699000.0 18153000.0 False True 26240813.580083784 16183559.541010516 14565051.593257442 1.0 0.6167323849018725 0.5550533541502694 24.645309114722274 -13.999999999999998 0.2570996358613592 3.7637884685239578 0.5318758636200787 0.9995564729884854 0.004145236536800758 14.29098091247439 0.1604501184738995 20.48498426112132 0.027383848763843383 1.0000000000000041e-14 13.999999999999998 -3.2319126049038793 MIVLGFSNPINWVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MIVLGFSNPINWVR 14 0 H7C0V0;Q8WWC4 H7C0V0 C2orf47 Uncharacterized protein C2orf47, mitochondrial 0 42485000.0 17297000.0 13498000.0 11690000.0 False True 22391307.47484364 12746824.434304401 9562539.949529167 1.0 0.5692755748464132 0.42706483130887124 24.416435436814723 -13.999999999999998 0.15488360477024435 3.0999512604746697 0.2790609135428151 0.9995507661688188 0.005162810651798637 11.979458941772194 0.12417542239275102 7.562208395455692 0.13407933244761572 1.0000000000000041e-14 13.999999999999998 -2.8208903469318547 MIVQENK(ub)GLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MIVQENKGLK 10 1 Q6NXE6-2;Q6NXE6;B4E1N1;F5GWV0;F5H4P3 Q6NXE6-2 ARMC6 Armadillo repeat-containing protein 6 1 3680580.0 1267780.0 1115900.0 1296900.0 True False 1662071.8571989855 949412.0697441304 1162709.228743244 1.0 0.5712220356971398 0.699554128004252 20.66455132555014 -10.626451319100196 9.761946303468992 1.0000822751524634 0.6353880818506977 0.9149870574270866 0.052391357296029215 9.383462629401626e-05 3.590651151440298e-06 0.05073898667919073 0.01690923785772697 2.36346230932099e-11 10.626451319100196 -0.36469419330176567 MIVQENK(ub)GLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MIVQENKGLK 10 1 Q6NXE6-2;Q6NXE6;B4E1N1;F5GWV0;F5H4P3 Q6NXE6-2 ARMC6 Armadillo repeat-containing protein 6 1 6843500.0 1160700.0 1168400.0 4514400.0 True False 1123854.2138350585 1634948.2131255066 3331943.2109029824 1.0 1.4547689486756317 2.964746823818905 20.100023470881002 -6.949150412464176 0.5680931016233584 0.9810256077124965 3.511664308963657 0.9991329227657151 0.02472831618449464 0.08382867475704749 0.03738797805158295 0.026255476542717756 0.12575264026117103 1.124215548534423e-07 6.949150412464176 2.5306387012511604 up MIVQENK(ub)GLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MIVQENKGLK 10 1 Q6NXE6-2;Q6NXE6;B4E1N1;F5GWV0;F5H4P3 Q6NXE6-2 ARMC6 Armadillo repeat-containing protein 6 1 43142900.0 1721800.0 4680100.0 36741000.0 True False 2612096.480441011 3844899.5892118043 29479125.245847613 1.0 1.4719592549516602 11.285618837812043 21.316776754601765 -6.916920166521978 0.8472585028155807 0.7585146032826064 12.761220523718478 0.9932816982019061 0.3886269023781616 0.1000178682506046 0.1152559566348823 0.3294917775103313 0.9597022841352963 1.210820690241809e-07 6.916920166521978 12.002705920435872 up MIVQENK(ub)GLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MIVQENKGLK 10 1 Q6NXE6-2;Q6NXE6;B4E1N1;F5GWV0;F5H4P3 Q6NXE6-2 ARMC6 Armadillo repeat-containing protein 6 1 4275880.0 1267780.0 1258600.0 1749500.0 True False 1736512.5264662805 1202990.8903663727 1336304.1320835105 1.0 0.6927625755826832 0.76953325226097 20.72776138707303 -10.376172877895549 5.590293040999094 1.0000875259818138 0.7311479139218255 0.9423702467705936 0.03134149751167028 3.420060970666163e-05 3.816488814596184e-06 0.03035611483167992 0.010115424825657514 4.205591847199902e-11 10.376172877895549 -0.2689396120599883 MIVQENK(ub)GLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MIVQENKGLK 10 1 Q6NXE6-2;Q6NXE6;B4E1N1;F5GWV0;F5H4P3 Q6NXE6-2 ARMC6 Armadillo repeat-containing protein 6 1 4616600.0 1160700.0 1969000.0 1486900.0 True False 965173.4777284915 1958392.6061840993 1797803.9153511683 1.0 2.0290576268145295 1.8626743863520254 19.88042874631528 -10.181041004777727 4.504771884471342 0.9998068078541869 1.9458660066003695 0.9773192382580691 0.06792567353861642 7803296.4429097725 17635939.551401816 9225.348908158636 0.02325276285604938 6.591116609673207e-11 10.181041004777727 0.9460591987461826 MIVQENK(ub)GLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MIVQENKGLK 10 1 Q6NXE6-2;Q6NXE6;B4E1N1;F5GWV0;F5H4P3 Q6NXE6-2 ARMC6 Armadillo repeat-containing protein 6 1 36945500.0 1721800.0 3534700.0 31689000.0 True False 2228904.0417520786 3337990.837748983 25921927.1565979 1.0 1.4975928865583117 11.629898223981597 21.087903076694214 -6.917117585780765 0.8458333197393493 0.7523808489308551 13.160178378778445 0.9933419943991968 0.39965304396739504 0.09989746893157157 0.11462305779751489 0.33918630703829294 0.989633591373835 1.21027040694148e-07 6.917117585780765 12.40779752984759 up MIYASSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MIYASSK 7 0 P60981;P60981-2;F6RFD5;P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;Q9Y281;Q9Y281-3 P60981;P23528 DSTN;CFL1;CFL2 Destrin;Cofilin-1;Cofilin-2 0 27389600.0 5391000.0 13374000.0 8624600.0 False True 7067653.206518271 11378651.331443695 7732209.125005 1.0 1.6099617509457775 1.0940278051381795 22.75279982122406 -10.23123540348758 4.386355622270672 0.999850716503143 1.3519947780485122 0.3829506821604808 0.21062915139172367 0.00030794179859345894 5.3969924643645014e-05 0.20402690195726744 0.06798026629387936 5.871709981089706e-11 10.23123540348758 0.35214406154536915 MIYASSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MIYASSK 7 0 P60981;P60981-2;F6RFD5;P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;Q9Y281;Q9Y281-3 P60981;P23528 DSTN;CFL1;CFL2 Destrin;Cofilin-1;Cofilin-2 0 21374600.0 5391000.0 7656600.0 8327000.0 False True 7384198.386297086 7318306.095009684 6360334.099948215 1.0 0.9910765816625838 0.8613438815174761 22.81600988274695 -6.92081288032898 0.8186902795938078 1.002779549886932 0.840028168272413 0.9944033525182763 0.004740353812787538 0.09769610646074517 0.10315831668404687 0.004101954639474885 0.012384144814455704 1.2000162295309537e-07 6.92081288032898 -0.16275138161451908 MIYASSK(ub)DAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MIYASSKDAIK 11 1 P60981;P60981-2;F6RFD5;P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;Q9Y281;Q9Y281-3 P60981;P23528 DSTN;CFL1;CFL2 Destrin;Cofilin-1;Cofilin-2 1 1942580.0 451450.0 635510.0 855620.0 True False 618363.264977521 607431.0668494627 653540.178047039 1.0 0.9823207510095935 1.056887132631976 19.238095090256927 -6.844165846622252 1.2628047997332477 0.9905932952232984 1.0595505036869552 0.931388571003152 0.00833313818344969 0.16399722729606714 0.5061840393944652 0.005170287595968618 0.01192877502681851 1.4316410855585872e-07 6.844165846622252 0.06895720846365683 MIYASSK(ub)DAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MIYASSKDAIK 11 1 P60981;P60981-2;F6RFD5;P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;Q9Y281;Q9Y281-3 P60981;P23528 DSTN;CFL1;CFL2 Destrin;Cofilin-1;Cofilin-2 1 4256470.0 911970.0 1889200.0 1455300.0 True False 758343.4621211779 1879022.5046231595 1759596.5014530602 1.0 2.477798779153851 2.3203160432493966 19.532491883348733 -10.169893092426236 4.4839315665403205 0.9997348750478474 2.3990574112319165 0.9905865563467314 0.0642920578170833 22531261.45216307 31.30347589748182 61709.65312835874 0.02200888144341953 6.762494230224856e-11 10.169893092426236 1.399322536184069 MIYASSK(ub)DAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MIYASSKDAIK 11 1 P60981;P60981-2;F6RFD5;P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;Q9Y281;Q9Y281-3 P60981;P23528 DSTN;CFL1;CFL2 Destrin;Cofilin-1;Cofilin-2 1 7763400.0 0.0 1855200.0 5908200.0 True False 0.0 1751956.4891481332 4832968.223251345 0.0 MIYCIHALSLYLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MIYCIHALSLYLFK 14 0 Q13576;F5H7S7;E7EWC2;D6R939 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 0 65437000.0 14493000.0 18503000.0 32441000.0 False True 21986940.580225114 15200995.085401144 26029022.130604573 1.0 0.6913647230698755 1.1838401088878585 24.390143535489116 -6.737254340409124 1.6965892525463024 0.8157853930043208 1.1839691444027631 0.592644657083718 0.12968641860983485 0.3227955918238518 1.823251021797221 0.06049612896359729 0.1489109897328026 1.8312416591140103e-07 6.737254340409124 0.3681837513984423 MIYCIHALSLYLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MIYCIHALSLYLFK 14 0 Q13576;F5H7S7;E7EWC2;D6R939 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 0 55820700.0 18208800.0 15188400.0 22423500.0 False True 23571650.54910867 14343152.188323375 18342653.084539544 1.0 0.6084916352565621 0.778165832991833 24.490549447646522 -10.209862225920922 5.434948806202495 1.0000155709365108 0.6933287341241627 0.8132814136256895 0.06926920116137397 1.3069957209616586e-05 1.9001109062960274e-06 0.06707301816194017 0.0223565385419067 6.167906393569171e-11 10.209862225920922 -0.3066868368123481 MIYEQK(ub)IAELQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MIYEQKIAELQR 12 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;H0Y636;H0Y4K0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 45501000.0 10436000.0 15274000.0 19791000.0 True False 13681697.062367756 12995178.737585673 17743217.168677233 1.0 0.9498221367091668 1.2968579181219344 23.70574385581041 -6.870197545656868 1.1329916489902887 0.9715844006956311 1.31726361938448 0.9648829503910682 0.028698385038537222 0.1366686417192191 0.3277646640317637 0.01965481513965712 0.04655166064738238 1.3483494251973775e-07 6.870197545656868 0.3456792186888489 MIYEQK(ub)IAELQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MIYEQKIAELQR 12 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;H0Y636;H0Y4K0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 80063800.0 19021000.0 28875800.0 32167000.0 True False 18417188.76656898 40406057.52530775 23741497.71068498 1.0 2.1939318773043763 1.2890945524639854 24.134549526832277 -10.297475839917947 5.077266357927221 0.9997989904869165 1.7415132148843693 0.47241745250298117 0.3693982910146397 0.0008407334728350711 0.00011632968144900026 0.3577633022930864 0.11922278576800441 5.041086622125523e-11 10.297475839917947 0.7417142243974528 MIYEQK(ub)IAELQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MIYEQKIAELQR 12 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;H0Y636;H0Y4K0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 48289000.0 10436000.0 15454000.0 22399000.0 True False 14294471.222295731 14771191.180455998 17108817.521885447 1.0 1.0333499540309476 1.1968835541954188 23.768953917333302 -6.94024044985929 0.6573207663564062 0.9981717108490059 1.2412973608680355 0.9981952499593054 0.0036549754015860036 0.08765704323379092 0.0541109704834618 0.003564366426536682 0.014060157103338999 1.1475181149973579e-07 6.94024044985929 0.24312565001902964 MIYEQK(ub)IAELQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MIYEQKIAELQR 12 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;H0Y636;H0Y4K0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 51511500.0 29689200.0 7868300.0 13954000.0 True False 38433254.66162495 7430422.18820842 11414515.18013089 1.0 0.1933331499928261 0.2969957990970803 25.195851818217392 -10.70006053728125 6.859651650547587 1.0066125972063633 0.24516447488031873 0.9860523453684075 0.042320099281767075 0.004270625927446586 0.00018673357214604678 0.04088849686196968 0.013658753310677356 1.9949842102659336e-11 10.70006053728125 -0.7614481223260445 MK(ub)AIVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MKAIVEK 7 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 4040900.0 1354000.0 1484600.0 1202300.0 True False 1775107.1121546517 1263103.466925475 1077897.5292759656 1.0 0.7115646477199346 0.607229570483551 20.759474650567956 -13.999999999999998 0.14149204020137562 2.37973084488452 0.4804013174532417 0.9995970519380227 0.0033345264180592803 11.935829320446244 0.11795953093438875 4.543191925777073 0.11350045626319687 1.0000000000000041e-14 13.999999999999998 -1.8993295274312783 MK(ub)AIVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MKAIVEK 7 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 5098500.0 1083300.0 1890400.0 2124800.0 True False 1048911.2344684405 2645246.578305767 1568251.1373663535 1.0 2.5218974603187516 1.495122833879361 20.000461162386426 -10.51870624973311 5.455086048743756 0.9976111908726915 2.0085101470990585 0.5626159084725499 0.41917898593556024 0.012196017842398248 0.001076034541988414 0.4064610005827396 0.1352894359673771 3.0289614794543035e-11 10.51870624973311 1.010898956226367 MK(ub)AIVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MKAIVEK 7 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 3738500.0 1354000.0 857300.0 1527200.0 True False 1854610.3904741686 819421.6512880115 1166506.8136713004 1.0 0.4418295376197638 0.628976748789302 20.822684712090847 -10.077467908480827 5.581176544915979 1.0000032980846343 0.535403143204398 0.8915073362832386 0.0764025290255258 3.1353776986477797e-06 5.182719658594799e-07 0.07397695520779525 0.024658810210262443 8.366274147608748e-11 10.077467908480827 -0.4646001548802363 MK(ub)AIVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MKAIVEK 7 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 4477800.0 1083300.0 2027900.0 1366600.0 True False 900811.9483271088 2016975.3001933664 1652349.7415555243 1.0 2.239063662442618 1.8342893260064888 19.780866437820702 -10.114527290693081 4.559585930560015 0.9999067170309222 2.0366764942529807 0.8973916455486964 0.16524843097374103 0.000159792785146445 3.103186532114517e-05 0.1600156206114723 0.05333370174823119 7.681971813099437e-11 10.114527290693081 1.0367697772220585 MK(ub)DNDLLVSELYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MKDNDLLVSELYR 13 1 M0R2P6;Q8TBC3;M0QZF4;M0R0S1;M0R0E3 M0R2P6 SHKBP1 SH3KBP1-binding protein 1 1 23803300.0 6848800.0 7942200.0 9012300.0 True False 8978843.123873549 6757254.718453117 8079793.648086001 1.0 0.7525752065415283 0.8998702323468494 23.09809814269059 -10.259471946312415 5.244984783244032 1.0000226951888609 0.8262227195816142 0.6498445361286358 0.06013294247895294 1.5960618932769097e-05 2.253453153257397e-06 0.058231070797721 0.019407823731605024 5.5020946069471e-11 10.259471946312415 -0.1737999756072467 MK(ub)DNDLLVSELYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MKDNDLLVSELYR 13 1 M0R2P6;Q8TBC3;M0QZF4;M0R0S1;M0R0E3 M0R2P6 SHKBP1 SH3KBP1-binding protein 1 1 31134500.0 10709000.0 10969000.0 9456500.0 True False 10369048.65681023 15348978.902579343 6979558.961081002 1.0 1.4802687701246702 0.6731146889253853 23.30578019953313 -6.745574692138289 1.6667855071500568 1.2839067739636054 0.6720895858917096 0.6294862461425246 0.20178143751404506 0.3078230450726959 1.681224000489566 0.09570232981254448 0.23337798619149225 1.796492083904318e-07 6.745574692138289 -0.6118171880718958 MK(ub)DNDLLVSELYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MKDNDLLVSELYR 13 1 M0R2P6;Q8TBC3;M0QZF4;M0R0S1;M0R0E3 M0R2P6 SHKBP1 SH3KBP1-binding protein 1 1 24168600.0 6848800.0 9924200.0 7395600.0 True False 9380986.441860778 9485716.029059257 5648911.597163084 1.0 1.0111640271359037 0.6021660549423613 23.16130820421348 -6.9006235791032475 0.9572993636982594 1.0167149137723186 0.5586842476860748 0.9868745097990226 0.021793614121842733 0.11094833895859979 0.17483474773061974 0.01705389975665642 0.044512659365415375 1.2571190884709027e-07 6.9006235791032475 -0.45803066608624377 MK(ub)DNDLLVSELYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MKDNDLLVSELYR 13 1 M0R2P6;Q8TBC3;M0QZF4;M0R0S1;M0R0E3 M0R2P6 SHKBP1 SH3KBP1-binding protein 1 1 29707100.0 10709000.0 11128000.0 7870100.0 True False 8905007.989139665 11068051.255264942 9515701.522769006 1.0 1.2429018894495403 1.0685786620712894 23.086185474967408 -10.228831648477946 4.2279172331379336 0.9999146189645691 1.155740275767077 0.5155547533666517 0.07116715958934923 50170386.89430596 6.357632511042412 41759.45066867723 0.024362411659378136 5.904299122550873e-11 10.228831648477946 0.15582565680250782 MK(ub)DNDLLVSELYRDPAEDGVTALSVYLTPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MKDNDLLVSELYRDPAEDGVTALSVYLTPK 30 2 M0R2P6;Q8TBC3;M0QZF4;M0R0S1;M0R0E3 M0R2P6 SHKBP1 SH3KBP1-binding protein 1 1 71055000.0 25885000.0 25419000.0 19751000.0 True False 33508642.76963215 24004410.304903213 16156520.662373874 1.0 0.7163647441625917 0.482159804962797 24.998029917176623 -7.090238573423647 0.16840708746174074 1.2195383817090144 7.867124737357136e-12 0.9999971599720164 0.00035676570725372704 0.07554345991019769 0.005792389144104475 0.01156906606305515 0.028837731560937285 8.123841220389114e-08 7.090238573423647 -1.2195383817011474 down MK(ub)DTDSEEEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MKDTDSEEEIR 11 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 1 14129470.0 7485500.0 4715300.0 1928670.0 True False 9813562.989685118 4011795.6200954416 1729109.7295090083 1.0 0.40880112802171614 0.17619591694947578 23.22634559713425 -10.422461861656593 0.2083675320279675 1.7573104014170113 4.852300583562633e-16 0.9993408393018383 0.00890313607254347 2.101526215305338 0.10450431792624702 0.9685772766745745 0.1329109763699394 3.780403341294018e-11 10.422461861656593 -1.757310401417011 MK(ub)DTDSEEEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MKDTDSEEEIR 11 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 1 15519160.0 5826060.0 6971200.0 2721900.0 True False 5641114.914324007 9754836.514327748 2008952.734750316 1.0 1.729239106538694 0.35612689428629646 22.427548895495235 -6.762392960315958 1.6032317142208934 1.4223079539277412 0.3504644470231488 0.7007786731526839 0.306835962886728 0.27889944679939566 1.413355750746959 0.15096053837298776 0.3619634900814853 1.7282518867724856e-07 6.762392960315958 -1.0718435069045924 MK(ub)DTDSEEEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MKDTDSEEEIR 11 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 1 18963780.0 15246200.0 1559900.0 2157680.0 True False 23129600.04652095 1281523.6574456706 1731213.602255262 1.0 0.055406217784489176 0.07484840199455431 24.46323698354104 -10.678982283431795 3.021230864098491 1.1002016774711794 0.06512730877887325 0.9996757304392138 0.007937241942679146 8399661.189246489 8388703.122795196 6476468.251215118 0.0029125721248177377 2.0941978846197267e-11 10.678982283431795 -1.035074368692306 MK(ub)DTDSEEEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MKDTDSEEEIR 11 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 1 12450340.0 7485500.0 2732270.0 2232570.0 True False 10253091.63803131 2611549.2769913645 1705282.9472224568 1.0 0.2547084693268973 0.16631890237839397 23.289555658657143 -13.999999999999998 0.3008104109432645 7.830077417092489 0.14475263731269347 0.9996516384871432 0.0069788706625860345 16.641365904799986 0.17420636733504835 70.77658697757866 0.03183241915054936 1.0000000000000041e-14 13.999999999999998 -7.685324779779795 MK(ub)DTDSEEEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MKDTDSEEEIR 11 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 1 18367480.0 5826060.0 10809700.0 1731720.0 True False 4844627.02821991 10751466.000542544 2093814.6454313851 1.0 2.219255669820473 0.4321931560953884 22.20795417092951 -6.723042311033769 1.748457771993791 1.7393764826183002 0.4345166958957512 0.5267485966307439 0.5128871092237252 0.34946417316540007 2.0895026131001666 0.23277219174641445 0.5822449720858079 1.8921592665107462e-07 6.723042311033769 -1.304859786722549 MK(ub)DTDSEEEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MKDTDSEEEIR 11 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 1 21249400.0 12751000.0 7301300.0 1197100.0 True False 16506420.859786713 6894976.2366414815 979240.0832832648 1.0 0.41771479687878105 0.059324798004448676 23.97652399417702 -8.382644806914245 0.4251876221333021 1.0754939586787915 2.4911176987080302e-17 0.9962217311691633 0.023827188992032657 0.15107469879552302 0.12636019918341657 0.0783854694333459 0.07793827556446266 4.143384080474847e-09 8.382644806914245 -1.0754939586787915 MK(ub)EIAEAYLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MKEIAEAYLGK 11 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 6361000.0 1130700.0 3511100.0 1719200.0 True False 1482358.649714376 2987257.566160607 1541313.6757308831 1.0 2.0152056769366835 1.0397710945511511 20.49946311249111 -6.636865419233552 2.055945709370851 1.665475076054031 1.0438164041013518 0.1425857599070588 0.4347221330396528 0.5413619592619052 4.369523309566138 0.17242981815441819 0.48134512562950177 2.3074621227643608e-07 6.636865419233552 -0.6216586719526791 MK(ub)EIAEAYLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MKEIAEAYLGK 11 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 22119800.0 5175700.0 8329300.0 8614800.0 True False 5011400.236534948 11655232.926725684 6358325.44153975 1.0 2.325743779503931 1.2687722276072109 22.256782332836163 -6.589675589344962 2.231204598915356 1.8975014139784498 1.2719002196831435 0.0 0.5745447107527076 0.6703729434809014 6.291803478242858 0.21506970323793728 0.6400646660419798 2.572316542375554e-07 6.589675589344962 -0.6256011942953064 MK(ub)EIAEAYLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MKEIAEAYLGK 11 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 3755700.0 1130700.0 1340500.0 1284500.0 True False 1548750.3460185695 1281272.2775592909 981127.5551079 1.0 0.8272942639548753 0.6334962620864759 20.562673174014 -6.969632072137084 0.2668275535751121 1.05006773498653 0.40492120504319806 0.9999793676856824 0.0006799871416068825 0.0764222652110249 0.009456504421352346 0.003874048121042142 0.018104223135438333 1.0724274651833776e-07 6.969632072137084 -0.6451465299433319 MK(ub)EIAEAYLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MKEIAEAYLGK 11 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 13643000.0 5175700.0 5214900.0 3252400.0 True False 4303823.872386797 5186806.298623396 3932461.8026014874 1.0 1.2051623050612705 0.9137134602166326 22.03718760827044 -6.717499579518522 1.7680008231835513 1.1251459029877044 0.9142199925974234 0.5008695577262854 0.08636019275893078 0.36017985231462946 2.1988515898825858 0.038802783819053555 0.09770862157454323 1.9164629182431202e-07 6.717499579518522 -0.21092591039028108 MK(ub)EIAEAYLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MKEIAEAYLGK 11 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 17941700.0 6414300.0 4715600.0 6811800.0 True False 8303437.794755696 4453172.714654458 5572122.294970303 1.0 0.5363046998999622 0.6710620868972555 22.985277335012288 -10.581993128001985 9.640004141772252 1.000037021524061 0.6036833933986147 0.9202065556445699 0.05501447286902221 4.377751255770058e-05 1.8982668439924128e-06 0.05327247457642854 0.017755844768508566 2.6182244369995355e-11 10.581993128001985 -0.3963536281254464 MK(ub)ESPGSQQCCQESEVLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 MKESPGSQQCCQESEVLER 19 1 H7BYP4;U5Y3L1;Q9H930-2;Q9H930;Q13342-3;Q13342-6;Q13342-5;Q13342 H7BYP4 SP140L;SP140 Nuclear body protein SP140-like protein;Nuclear body protein SP140 1 12562500.0 3299700.0 4964800.0 4298000.0 True False 5005886.140382858 4078792.649840545 3448498.416119676 1.0 0.8147993253255641 0.6888887040998358 22.255194046412523 -7.685215011177629 0.06916172440709964 1.5894734329833822 0.0005953232576139241 0.9999989217472851 0.0001325567814996417 0.1386092527521072 0.007842346214543027 0.08005705108553426 0.09656871798981545 2.0643578773144116e-08 7.685215011177629 -1.5888781097257683 MK(ub)ETQKSIYYITGESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MKETQKSIYYITGESK 16 2 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 18681400.0 3492200.0 4662200.0 10527000.0 True False 5297922.714017955 3830193.984065137 8446333.835851986 1.0 0.722961468262022 1.5942727540180122 22.336995367181142 -6.821168202854425 1.3666667691916667 0.8508511618114181 1.6138004000598065 0.8870887732604521 0.12213928325818925 0.1919600051896793 0.7041659305186103 0.07022163044260134 0.16181291962416766 1.509495411271856e-07 6.821168202854425 0.7629492382483885 MK(ub)ETQKSIYYITGESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MKETQKSIYYITGESK 16 2 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 12960600.0 3492200.0 2754300.0 6714100.0 True False 4520721.741553387 2601020.7837757156 5492202.692483641 1.0 0.5753552048708857 1.2148951000457815 22.10812168927359 -6.727652637507568 1.7314486775349758 0.7437953321080467 1.214380821489022 0.5485451876880547 0.1785453651016369 0.3406335730347749 1.9994380293650458 0.08174886778488781 0.2034219404608632 1.8721789697625658e-07 6.727652637507568 0.4705854893809752 MK(ub)IDPEAFITR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MKIDPEAFITR 11 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 3853670.0 860270.0 1756900.0 1236500.0 True False 1127822.300866531 1494777.3683425628 1108558.8413455312 1.0 1.3253660325692196 0.982919774235534 20.10510834463713 -6.657765569916113 1.981092373085348 1.2098192443798685 0.9843593655456556 0.2260937907967685 0.13860791949711637 0.48972512672653357 3.6925318474855944 0.05657675883535134 0.15359259916112983 2.1990465872933008e-07 6.657765569916113 -0.22545987883421292 MK(ub)IDPEAFITR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MKIDPEAFITR 11 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 5159300.0 1275100.0 1411100.0 2473100.0 True False 1234622.6484544517 1974559.5887892866 1825320.9185903266 1.0 1.5993223445731508 1.4784443820752307 20.235638731465315 -10.095661474518005 4.445898690685639 0.9999506221635681 1.538883363351883 0.9636354070690395 0.04934822166424588 17167935.733461417 0.9189491296439584 9032.12262361134 0.01689320884347881 8.023032020045744e-11 10.095661474518005 0.5389327411883149 MK(ub)IDPEAFITR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MKIDPEAFITR 11 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 4306500.0 1275100.0 1748600.0 1282800.0 True False 1060302.1465077961 1739179.9447300732 1551027.5490029457 1.0 1.640268248497114 1.4628165698913271 20.01604400689959 -10.058789806398902 4.439579732114599 0.9999668340905181 1.5515424091231822 0.9279570413094712 0.07244434462031579 50618784.842316486 67948318.09145305 24070.926544587197 0.026511912753570035 8.733939788854883e-11 10.058789806398902 0.5515755750326641 MK(ub)ITDFENR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MKITDFENR 9 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 8443100.0 2800000.0 2173000.0 3470100.0 True False 2711115.532642508 3040690.232045302 2561176.7092314498 1.0 1.1215642400460741 0.944694786479677 21.37045516343632 -6.721775850838334 1.7532039710821086 1.0738197581904814 0.9449482296905094 0.5207312995933898 0.051143979283834136 0.3518928806810247 2.1148372515382494 0.023155595875680536 0.058002041911455665 1.897685106515655e-07 6.721775850838334 -0.12887152849997197 MK(ub)ITDFENR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MKITDFENR 9 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 4405300.0 1910900.0 1049000.0 1445400.0 True False 2617411.370130788 1002651.7114208854 1104026.288947418 1.0 0.3830699762608521 0.42180083021961184 21.31970925527199 -9.92188220442986 5.842811659825378 1.0000003000168403 0.40243540323982624 0.9968592051407866 0.01581180491830838 6.180489009391986e-08 1.1401148536941473e-08 0.015309722036141211 0.005103238093297228 1.1970651724409662e-10 9.92188220442986 -0.597564896777014 MK(ub)LDYILGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MKLDYILGLK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 1 2415270.0 668240.0 853790.0 893240.0 True False 876069.1112453645 726407.8600473535 800816.0933631074 1.0 0.8291673005280805 0.91410150533069 19.74068515992312 -10.11819036225555 4.5175692809828 1.0000129757731 0.8716344029260206 0.7528169766541407 0.03467424392731073 8037883.094415704 18002785.699516594 627.2330444253779 0.011869917497779485 7.6174504471896e-11 10.11819036225555 -0.12837857284707943 MK(ub)LDYILGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MKLDYILGLK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 1 5978700.0 1957100.0 2277100.0 1744500.0 True False 1894972.931762376 3186357.9049196276 1287563.1161218018 1.0 1.6814793770991907 0.6794625371900871 20.853745810073526 -6.723590995693859 1.746366463942152 1.4130199763680065 0.6807059125811438 0.5293226361839531 0.2866524150748967 0.3484376026345016 2.0786416889969987 0.130234051853192 0.32556683915263374 1.8897702349740143e-07 6.723590995693859 -0.7323140637868627 MK(ub)LDYILGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MKLDYILGLK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 1 22599800.0 3269200.0 4855600.0 14475000.0 True False 4959615.410534189 3989080.243024047 11614009.905382132 1.0 0.804312413932594 2.341715827544623 22.241796821624416 -6.874945022994197 1.1075605873457628 0.8852056275272513 2.4406547720125253 0.9693761910215909 0.1195753772268528 0.13220408528243707 0.30012238585081286 0.08350781174515863 0.19959798081005445 1.3336902523051506e-07 6.874945022994197 1.555449144485274 up MK(ub)LDYILGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MKLDYILGLK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 1 4308690.0 668240.0 825950.0 2814500.0 True False 915306.3865069849 789456.7979485985 2149773.0664470075 1.0 0.862505505900973 2.3486923047167028 19.803895221446012 -6.884265371337603 1.0556760228322055 0.90882712177162 2.4630477035873604 0.9769681932502389 0.10176286583024302 0.12392099918362066 0.24999777078876267 0.07394481090051304 0.18092939774785952 1.305373009152776e-07 6.884265371337603 1.5542205818157404 up MK(ub)LDYILGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MKLDYILGLK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 1 4529200.0 1957100.0 1341700.0 1230400.0 True False 1627415.3642305748 1334471.9957934024 1487670.9512731729 1.0 0.8199947137799863 0.9141310718646978 20.634151085507803 -10.161074028609445 4.6690794976431995 1.0000160928945103 0.8670628928210543 0.7267003937950199 0.03843100726298709 53826131.20261637 0.036829462165370884 9312.66296101523 0.013155955990327787 6.901221575420018e-11 10.161074028609445 -0.132953200073456 MK(ub)LDYILGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MKLDYILGLK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 1 39680400.0 3269200.0 3176200.0 33235000.0 True False 4232043.845566213 2999441.677895809 27186571.0198975 1.0 0.708745416481976 6.423981417012033 22.012923143716865 -6.894896782959267 0.9929829551073379 0.7279812352459524 6.965384439148414 0.9838512906669366 0.3339890598690569 0.11525923365355394 0.19936726248703443 0.25449170318676273 0.6467087878529938 1.2738057853943838e-07 6.894896782959267 6.237403203902462 up MK(ub)LTDSVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MKLTDSVLR 9 1 Q6UXN9 Q6UXN9 WDR82 WD repeat-containing protein 82 1 2461640.0 983420.0 860950.0 617270.0 True False 1347016.949926224 822910.3822190769 471483.53907470126 1.0 0.6109131605687275 0.3500204946200004 20.36133657411151 -8.255467809252643 0.1891196175388378 1.3021701068493143 1.6222986764291725e-06 0.9998184174533616 0.003598802624621126 0.08855448003203616 0.04046095064220487 0.11499541312347661 0.1194310144315922 5.5530577593278605e-09 8.255467809252643 -1.3021684845506378 down MK(ub)PGFEVK(ub)PPELDPLHPAANPMEHFAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MKPGFEVKPPELDPLHPAANPMEHFAR 27 2 Q9P2R6;B1AKN3;Q9P2R6-2 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 2 8420000.0 1975200.0 3255700.0 3189100.0 True False 2589506.327864011 2769962.250619205 2859122.5240073088 1.0 1.0696873843533126 1.1041187631951819 21.30424565324838 -13.99999999999601 0.09208941706245966 0.6462750572087873 1.1873544962107183 0.9998325065682644 0.0005604977292696839 12.14538459576969 0.08867794105558312 0.8352041255748529 0.07465040842503831 1.0000000000091866e-14 13.99999999999601 0.541079439001931 MK(ub)PGFEVKPPELDPLHPAANPMEHFAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MKPGFEVKPPELDPLHPAANPMEHFAR 27 2 Q9P2R6;B1AKN3;Q9P2R6-2 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 52732300.0 19649500.0 16223400.0 16859400.0 True False 25760684.78602866 13802931.958317904 15114951.014784344 1.0 0.5358138602667869 0.5867449231389205 24.618667608761758 -10.816847802000268 10.964025996436908 1.0043062828885758 0.561279391945363 0.9899934806392616 0.02079251934905605 0.0021843491602627435 3.648911039040365e-05 0.02009244877362612 0.006710756763715801 1.5245869499238773e-11 10.816847802000268 -0.4430268909432128 MK(ub)PGFEVKPPELDPLHPAANPMEHFAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MKPGFEVKPPELDPLHPAANPMEHFAR 27 2 Q9P2R6;B1AKN3;Q9P2R6-2 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 115828000.0 36087000.0 40559000.0 39182000.0 True False 34941437.93802515 56754420.21239085 28919058.765195947 1.0 1.6242725989999296 0.8276436366611196 25.058435644629103 -6.6977144001593425 1.8395558142946062 1.3885167058857604 0.8301506129623102 0.4065869321963893 0.2636246329244577 0.4002450833451899 2.631681621002615 0.11441331479847626 0.2950152923005022 2.0057906376452487e-07 6.6977144001593425 -0.5583660929234502 MK(ub)PGFEVKPPELDPLHPAANPMEHFAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MKPGFEVKPPELDPLHPAANPMEHFAR 27 2 Q9P2R6;B1AKN3;Q9P2R6-2 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 90185000.0 31767000.0 36206000.0 22212000.0 True False 48192861.47878362 29744756.421230856 17821788.464134548 1.0 0.6172025380631457 0.3698014169999097 25.5223161286779 -8.446198614730644 0.17247754594298856 1.3622275856342025 3.523210359847173e-06 0.9998413448636477 0.003265456204271099 0.13298368700357105 0.04163932475867065 0.15082171837102493 0.1341459204888049 3.57932707261378e-09 8.446198614730644 -1.3622240624238426 down MK(ub)PGFEVKPPELDPLHPAANPMEHFAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MKPGFEVKPPELDPLHPAANPMEHFAR 27 2 Q9P2R6;B1AKN3;Q9P2R6-2 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 66268200.0 19649500.0 26011000.0 20607700.0 True False 26914451.157771163 24861748.0131255 15740585.688903924 1.0 0.9237323052729993 0.5848376991465811 24.68187767028465 -6.942468331873628 0.6361937188607418 1.0037020622136776 0.48640872479346525 0.9984695656880783 0.00705893306199392 0.08665861864261983 0.04961716725341196 0.007007351508442166 0.028865776686494725 1.1416465488012527e-07 6.942468331873628 -0.5172933374202124 MK(ub)PGFEVKPPELDPLHPAANPMEHFAR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MKPGFEVKPPELDPLHPAANPMEHFAR 27 2 Q9P2R6;B1AKN3;Q9P2R6-2 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 87162900.0 40768000.0 29956100.0 16438800.0 True False 33900398.328625076 29794720.543479703 19876077.075576577 1.0 0.8788899839658052 0.586308068799105 25.014798889294568 -6.956191613468016 0.48614792014706326 1.0066322009864284 0.44623987334774773 0.9996018236346159 0.0034652220242441635 0.08109073860322343 0.02637984219359633 0.004178129264330542 0.024131905672473464 1.1061356422692879e-07 6.956191613468016 -0.5603923276386806 MK(ub)PGFEVKPPELDPLHPAANPMEHFAR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MKPGFEVKPPELDPLHPAANPMEHFAR 27 2 Q9P2R6;B1AKN3;Q9P2R6-2 Q9P2R6 RERE Arginine-glutamic acid dipeptide repeats protein 1 156173300.0 52009200.0 78497600.0 25666500.0 True False 67326934.65460114 74129139.555064 20995460.360529542 1.0 1.1010324461578318 0.311843402172398 26.004680445700412 -6.874752048908001 1.108713112286293 1.0591553949476644 0.26126412576708496 0.9691971060575618 0.06154137126507735 0.13237708968061893 0.3012793275863752 0.04294297530974675 0.10259100389385281 1.334282994916858e-07 6.874752048908001 -0.7978912691805795 down MK(ub)PILLQGHER ddPTM_RPMI8226_Bortezomib_1h_R1 2 MKPILLQGHER 11 1 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 110332700.0 48021000.0 54337200.0 7974500.0 True False 62955996.03602545 46230301.56474667 7149375.236805456 1.0 0.7343272202109582 0.11356146653154932 25.907840453426424 -7.25684356293712 0.607298524338933 1.0008467829611547 4.0389678347315804e-25 0.997153545825373 0.019817100580153978 0.09446286014244921 0.06394952523712977 0.018957067544283116 0.057476932046544846 5.535494671675133e-08 7.25684356293712 -1.0008467829611547 down MK(ub)PILLQGHER ddPTM_RPMI8226_Bortezomib_2h_R1 1 MKPILLQGHER 11 1 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 155140000.0 67669000.0 65782000.0 21689000.0 True False 65520884.63513781 92049095.64859822 16008000.243947092 1.0 1.4048817588649247 0.24431904930908482 25.96545149997725 -6.812478961759208 1.404242972591271 1.2200171430277762 0.22287339830642428 0.8661634890728142 0.17595224255317016 0.20344082564751892 0.7902013798450634 0.09851466072499629 0.22762285508367447 1.5400011255101453e-07 6.812478961759208 -0.9971437447213519 down MK(ub)PILLQGHER ddPTM_RPMI8226_Bortezomib_8h_R1 1 MKPILLQGHER 11 1 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 150719000.0 76137000.0 21825000.0 52757000.0 True False 115505395.36028434 17930158.230496682 42329555.82578545 1.0 0.1552322138248949 0.36647254176959554 26.78338500188939 -10.382214353035229 5.118993739919541 1.0005084992593263 0.2608523778673798 0.9422792217915139 0.08623850276064277 0.0005007958582743693 6.043852295686949e-05 0.083554472922496 0.027833357082791606 4.1474928591902886e-11 10.382214353035229 -0.7396561213919465 MK(ub)PILLQGHER ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MKPILLQGHER 11 1 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 93544300.0 48021000.0 37563600.0 7959700.0 True False 65775661.41872968 35903915.94578602 6079782.79516727 1.0 0.5458541225031658 0.09243210427734364 25.971050514949315 -7.82082051901255 0.4661070487258204 1.0299979838993898 6.102453006491884e-18 0.9961072438832657 0.02311703497239013 0.1106467558770215 0.09415335726361217 0.034015023665228926 0.07796024617478542 1.5107043543340045e-08 7.82082051901255 -1.0299979838993898 down MK(ub)PILLQGHER ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MKPILLQGHER 11 1 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 217476100.0 80579000.0 126170000.0 10727100.0 True False 67005008.75496182 125490297.16721593 12970087.01349353 1.0 1.8728495003431096 0.19356891752563313 25.99776560807829 -6.765433076366075 1.5918206077584651 1.5035515735251712 0.18568338570135473 0.7128418537430024 0.3674695966785445 0.273873185498751 1.3687934954254366 0.18203605548967078 0.43518223000569106 1.7161961510449309e-07 6.765433076366075 -1.3178681878238165 MK(ub)PILLQGHER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MKPILLQGHER 11 1 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 47714900.0 28344100.0 11068100.0 8302700.0 True False 36691996.19574001 10452150.50535817 6791693.792896139 1.0 0.28486186604836944 0.18510014436567135 25.1289620594863 -13.999999999999998 0.2774965796245053 6.748716064615131 0.15431915605413868 0.999599651871211 0.0072616731723266275 15.264513090201032 0.1668384604537339 49.726382714065494 0.03993807169087444 1.0000000000000041e-14 13.999999999999998 -6.594396908560992 MK(ub)QDAQVVLYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MKQDAQVVLYR 11 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 6323060.0 971360.0 1407000.0 3944700.0 True False 940524.7084955827 1968822.4374080687 2911464.7315366417 1.0 2.09332346043019 3.0955749543185083 19.84310631968002 -6.972165143551881 0.1998126414398201 0.4019917348781711 4.814573248332792 0.999994711123029 0.001968086142050254 0.07560617856813127 0.006450177643151482 0.03259005452643509 0.10645171768601365 1.0661906176055417e-07 6.972165143551881 4.4125815134546205 MK(ub)QDAQVVLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MKQDAQVVLYR 11 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 2996760.0 971360.0 2025400.0 0.0 True False 807728.8785442818 2014488.7681895758 0.0 1.0 2.4940160265411833 0.0 19.623511595114298 -6.745727529356564 1.6737500915910137 1.8842721425291526 4.706571023878305e-07 0.6247772799379463 0.6277543866763113 0.30880110487965573 1.7020762500136353 0.29688449026699965 0.7217447953920895 1.795859972384877e-07 6.745727529356564 -1.8842716718720502 MK(ub)QEPVKPEEGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 MKQEPVKPEEGR 12 2 P61586 P61586 RHOA Transforming protein RhoA 1 99768330.0 41776800.0 37309900.0 20681630.0 True False 54769789.36710668 31743408.35285109 18541693.319803465 1.0 0.5795787918789288 0.3385387005146879 25.706876996292156 -9.146974621175262 0.166254961708446 1.4914067391683705 1.1938439963765193e-09 0.999756305639132 0.004266877894914295 0.5922881656128508 0.05738287846165139 0.3099170206065974 0.16318926188346208 7.128946882674383e-10 9.146974621175262 -1.4914067379745266 MK(ub)QEPVKPEEGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MKQEPVKPEEGR 12 2 P61586 P61586 RHOA Transforming protein RhoA 1 78519600.0 36673700.0 24314000.0 17531900.0 True False 35509513.46766845 34022706.99583501 12939769.444273889 1.0 0.9581293482607927 0.3644028932149577 25.08170225767122 -6.921127207883264 0.8163292379518151 1.0125757417188266 0.2661340239119364 0.9944881731437402 0.021549248620053075 0.09751324055528418 0.10221291826970852 0.01867850871176136 0.05656786052768469 1.1991480128863176e-07 6.921127207883264 -0.7464417178068902 down MK(ub)QEPVKPEEGR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MKQEPVKPEEGR 12 2 P61586 P61586 RHOA Transforming protein RhoA 1 54709440.0 28056900.0 10256000.0 16396540.0 True False 42564368.53414184 8425736.669506248 13155756.682141213 1.0 0.19795281733705916 0.30907909914342285 25.34314289162745 -10.773963897492802 7.182244461673451 1.0177653587714992 0.25351595824024103 0.9836508657463124 0.045367114573053466 0.012162244013825659 0.00038276372483278173 0.04139646962330327 0.014642173267243335 1.682813946056341e-11 10.773963897492802 -0.7642494005312581 MK(ub)QEPVKPEEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MKQEPVKPEEGR 12 2 P61586 P61586 RHOA Transforming protein RhoA 1 84125500.0 41776800.0 27002900.0 15345800.0 True False 57222811.93556961 25809822.59135085 11721438.096671708 1.0 0.451040795066338 0.20483855476849927 25.770087057815047 -9.859976200478823 0.2074616698184897 1.5793810508796908 1.8370372162321263e-12 0.9993851461750114 0.008241630453464384 1.3284530911117451 0.09138612065815424 0.5852005720044169 0.13733429352949791 1.3804599123167953e-10 9.859976200478823 -1.5793810508778539 MK(ub)QEPVKPEEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MKQEPVKPEEGR 12 2 P61586 P61586 RHOA Transforming protein RhoA 1 76895190.0 36673700.0 32563000.0 7658490.0 True False 30495806.470381126 32387576.65575056 9259844.850143094 1.0 1.0620337811760054 0.3036432192451334 24.862107533105497 -6.887072873401953 1.0395781213236528 1.0436545920047247 0.24204429027126068 0.9789563397839268 0.04987619313240708 0.12154876063608482 0.2359960556032949 0.036690317753161984 0.09055394972437965 1.2969616261833006e-07 6.887072873401953 -0.8016103017334639 down MK(ub)QEPVKPEEGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MKQEPVKPEEGR 12 2 P61586 P61586 RHOA Transforming protein RhoA 1 57993200.0 28056900.0 18054800.0 11881500.0 True False 36320210.13418162 17050034.508555286 9719188.914485106 1.0 0.46943656012907214 0.26759726550530605 25.1142692137199 -13.999999999905281 0.13421920390338885 3.525439163717166 2.358043732488981e-08 0.9996282161440949 0.005955688857257981 11.917635808313513 0.11418295945754835 7.912332726616098 0.23824111964961706 1.0000000002180983e-14 13.999999999905281 -3.525439140136729 MK(ub)QSNNEANLR ddPTM_RPMI8226_Bortezomib_1h_R1 2 MKQSNNEANLR 11 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 175472200.0 46225800.0 70439400.0 58807000.0 True False 60602471.45128405 59930116.09063072 52722215.75657631 1.0 0.9889054795200256 0.8699680804100147 25.852873294177193 -6.925085422332704 0.78607961826986 1.002175354817096 0.8483491287663004 0.9954811095834699 0.003956532959133585 0.09527116124026097 0.09077696281817428 0.0035042608455813544 0.011066795296656917 1.1882684813199824e-07 6.925085422332704 -0.15382622605079554 MK(ub)QSNNEANLR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MKQSNNEANLR 11 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 153985400.0 49173000.0 57562300.0 47250100.0 True False 47612030.03093932 80547226.57342887 34873881.337384135 1.0 1.6917410688241512 0.7324594501583389 25.504822806509114 -6.713244843034842 1.7839245909430603 1.4238542261944378 0.7345179851173481 0.48039652339228833 0.2913523115687197 0.3685763456209668 2.288474517910159 0.1298813990919043 0.3286326864870306 1.9353305712910716e-07 6.713244843034842 -0.6893362410770897 MK(ub)QSNNEANLR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MKQSNNEANLR 11 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 140057200.0 52424400.0 34302400.0 53330400.0 True False 79531647.53701471 28180868.714125503 42789623.06445527 1.0 0.3543352814489337 0.5380200761532146 26.245025721581488 -10.916350005309956 11.538880549799385 1.059998882105259 0.44617767880107645 0.923785450445683 0.07498900342222829 0.036243986543626705 0.0002627468184046848 0.022735927945497378 0.024202596783581755 1.2124113536951886e-11 10.916350005309956 -0.6138212033041825 MK(ub)QSNNEANLR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MKQSNNEANLR 11 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 157171600.0 46225800.0 51428100.0 59517700.0 True False 63316727.465273954 49155836.492015705 45460845.065508336 1.0 0.7763483436343929 0.7179910725872768 25.916083355700085 -13.999999999999998 0.18861235104540497 2.1932164627125013 0.6755354045241905 0.9994902290080105 0.002744208729803369 12.328477931679277 0.13772198318671194 5.403914200020451 0.04058047484383702 1.0000000000000041e-14 13.999999999999998 -1.5176810581883107 MK(ub)QSNNEANLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MKQSNNEANLR 11 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 140181900.0 49173000.0 64448900.0 26560000.0 True False 40889528.23325843 64101700.98359503 32113573.20043518 1.0 1.5676801311553514 0.785374020879871 25.28522808194339 -6.712043306919327 1.7876022004109524 1.3482550656371066 0.7870714457786031 0.47497511167812323 0.23914118147181834 0.37096865228611264 2.3119797093409544 0.10640166830411078 0.2696748514310055 1.9406923462426624e-07 6.712043306919327 -0.5611836198585035 MK(ub)QSNNEANLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MKQSNNEANLR 11 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 87285500.0 52424400.0 9067800.0 25793300.0 True False 67864419.23941678 8563168.958763175 21099184.0616074 1.0 0.12618053841370744 0.31090200576493915 26.016152043673937 -10.37410710832039 8.54409867581348 1.0000035092590172 0.21854127635153978 0.9597787962168672 0.07541222325811671 5.0411498564315086e-06 3.693032492922519e-07 0.07301789834730758 0.024339190398263513 4.225643860399243e-11 10.37410710832039 -0.7814622329074774 MK(ub)QSNNEANLREEVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MKQSNNEANLREEVLK 16 2 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 28676600.0 9490900.0 6102700.0 13083000.0 True False 14398389.177731238 5013625.504387272 10497139.315517407 1.0 0.34820738920860805 0.729049561443473 23.779404083150734 -10.744778791870417 7.025447483275499 1.0074303212778157 0.5386284753262666 0.6617984966415377 0.15547816575142767 0.018124234534938624 0.0006584181676831815 0.15078628947230985 0.05018036222117967 1.7997874043910644e-11 10.744778791870417 -0.46880184595154917 MK(ub)QSNNEANLREEVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MKQSNNEANLREEVLK 16 2 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 41203900.0 9490900.0 14291000.0 17422000.0 True False 12286157.143608345 13495693.287201356 14251374.764815819 1.0 1.0984470676595774 1.1599538080326315 23.550530405243183 MK(ub)SQAFIEMETR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MKSQAFIEMETR 12 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4 P43243 MATR3 Matrin-3 1 17333100.0 2217100.0 4878000.0 10238000.0 True False 3363502.7917213216 4007482.7880120403 8214454.812525184 1.0 1.1914611154406543 2.4422321969655085 21.68153302493683 -6.934062828667701 0.7126588309338051 0.9835438380376771 2.7277602487399975 0.997278169045863 0.033365624925424456 0.09058243813839766 0.06774435449584562 0.031168945229806014 0.11075399404816576 1.1639576293957338e-07 6.934062828667701 1.7442164107023204 up MK(ub)TEAESNSNMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MKTEAESNSNMR 12 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;H0YBA1 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 4342700.0 1836500.0 1343300.0 1162900.0 True False 1778201.3127492757 1879686.695216959 858301.603747803 1.0 1.0570719309113414 0.4826796592680407 20.76198723233565 -6.882456515483084 1.0659531325378415 1.0366705721967762 0.4399970082237509 0.9756156126782611 0.04034605540840378 0.12547860019666648 0.2592984540730488 0.02908799436196316 0.07080557553994454 1.3108212841366693e-07 6.882456515483084 -0.5966735639730253 down MKDTDSEEEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MKDTDSEEEIR 11 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2;A0A590UJC0;G3V226 P0DP25 CALM2;CALM1 0 20060070.0 6798600.0 2199370.0 11062100.0 False True 6582782.164365484 3077589.910563031 8164604.154113472 1.0 0.4675211534756415 1.2402968760398683 22.650266026599112 -6.721335105807301 1.7548826240157078 0.676503210632157 1.239153252112023 0.5186611675552452 0.22403287956877457 0.3527209326978114 2.1236611284183406 0.10134608944478907 0.25398226278979025 1.8996119553906528e-07 6.721335105807301 0.562650041479866 MKEIAEAYLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MKEIAEAYLGK 11 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 14167600.0 4749600.0 2993800.0 6424200.0 False True 6226771.595191827 2547136.7097409978 5759485.409277768 1.0 0.4090621714321173 0.9249553032786867 22.570052929874265 -10.346474756448806 8.41104284013691 1.0000010607279624 0.6670087373554066 0.35712035030666567 0.21061248913841024 4.189154058165031e-06 3.2587370821164775e-07 0.20392531289514548 0.06797488857802944 4.5032415581017585e-11 10.346474756448806 -0.3329923233725558 MKEIAEAYLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MKEIAEAYLGK 11 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 12148100.0 4749600.0 4476500.0 2922000.0 False True 6505655.473113819 4278713.428194087 2231883.7804790055 1.0 0.657691364978809 0.3430682411177168 22.633262991397157 -7.392449981443761 0.25121678533956127 1.1236932124656815 6.0717143522419445e-15 0.9999092023702678 0.0025562851698334595 0.1173080806105375 0.020120320199031597 0.02034717620460267 0.055947673000752506 4.05088597306555e-08 7.392449981443761 -1.1236932124656756 down MKEIAEAYLGYPVTNAVITVPAYFNDSQR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MKEIAEAYLGYPVTNAVITVPAYFNDSQR 29 1 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 112421900.0 14124900.0 64602000.0 33695000.0 False True 21428505.968510453 53073268.362270206 27035168.48095688 1.0 2.476760089586379 1.2616450498548761 24.353027930606803 -6.598027460955379 2.1984232824217065 1.994440521230859 1.2655311631028472 0.014807849254641403 0.6386280625307061 0.6463654374451534 5.90106770668839 0.24141356795261254 0.7105478591228328 2.5233212148417965e-07 6.598027460955379 -0.7289093581280117 MKEIAEAYLGYPVTNAVITVPAYFNDSQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MKEIAEAYLGYPVTNAVITVPAYFNDSQR 29 1 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 40533000.0 10020000.0 11322000.0 19191000.0 False True 12971087.523728576 10691920.747162128 15698434.916288642 1.0 0.8242886903355583 1.2102635871950451 23.628796107510905 -6.7829736461309444 1.5246638353612398 0.9008902850820654 1.2135898610838465 0.7776368901920324 0.07440362302114308 0.24598858297424522 1.1296821904665848 0.03843169865360627 0.09044547315679394 1.6482624083932349e-07 6.7829736461309444 0.3126995760017811 MKETAEAYLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MKETAEAYLGK 11 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 20599900.0 4869900.0 9155000.0 6575000.0 False True 6384486.06017868 7789109.6859105015 5894682.071853515 1.0 1.2200057471333112 0.9232821587033965 22.60613905953036 -6.70813830709142 1.8019883210149643 1.135512014099384 0.9240211135613617 0.45619926219209617 0.09273667267959952 0.3788241601181714 2.3967355824989958 0.0409736825857126 0.10432234263552131 1.9582209516173784e-07 6.70813830709142 -0.21149090053802222 MKETAEAYLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MKETAEAYLGK 11 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 14181200.0 4869900.0 6599800.0 2711500.0 False True 6670433.6340990765 6308199.013379937 2071099.5450954246 1.0 0.9456954913894344 0.31048949119409863 22.66934912105325 -6.923766515216343 0.7962985625597063 1.012205950549598 0.19862578784048074 0.9951646869255667 0.021766617525421927 0.09600617522236901 0.09450131471875965 0.01913843445282006 0.059566068795239534 1.191882614052316e-07 6.923766515216343 -0.8135801627091173 down MKGDVVVSLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MKGDVVVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 16445400.0 5735400.0 7340000.0 3370000.0 False True 7519164.941692607 6244900.6110959165 3021304.7273226366 1.0 0.8305311373699104 0.4018138650703045 22.84214101827845 -6.9552076810697905 0.49840878809126254 1.008705572190765 0.20519856668829506 0.9995491062458319 0.005345451122897286 0.08145961638019682 0.027811780040250176 0.006287752977696768 0.035363523943962874 1.1086445309681692e-07 6.9552076810697905 -0.8035070055024699 down MKGDVVVSLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MKGDVVVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 11739400.0 2446300.0 2515300.0 6777800.0 False True 2368643.5455369204 3519672.4071162157 5002490.850358458 1.0 1.4859443134650223 2.111964402488641 21.175629674707267 -6.967662579525524 0.30896069237829077 0.9023650674240623 2.7154130846137536 0.999957982409054 0.0029503639811589008 0.07706869002626404 0.011731168534883943 0.009951762438307652 0.05563490048043354 1.0773018867982292e-07 6.967662579525524 1.8130480171896912 MKGDVVVSLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MKGDVVVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 28646500.0 4869900.0 17517000.0 6259600.0 False True 7387994.337379304 14390954.489054313 5022387.316319854 1.0 1.9478838006471895 0.6798038935830335 22.816751329873284 -6.70661242779081 1.8071811913082196 1.5847421779696214 0.6830595302722297 0.44903365047459565 0.399651373588768 0.38193247903905425 2.4293102729515943 0.17612500861804578 0.4493045880835373 1.9651131969229527e-07 6.70661242779081 -0.9016826476973917 MKGDVVVSLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MKGDVVVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 18063000.0 5735400.0 5329900.0 6997700.0 False True 7855932.373357125 5094407.394377667 5344987.382155356 1.0 0.6484790286198253 0.6803759411527684 22.905351079801342 -9.957187215796234 5.688238376165576 1.0000003926616918 0.6644274852716888 0.993269413039414 0.013021860013658106 6.484245658657772e-08 1.1890619860307804e-08 0.012608376396192562 0.004202787247314973 1.1036027759284879e-10 9.957187215796234 -0.335572907390003 MKGDVVVSLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MKGDVVVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 6363200.0 2446300.0 2252100.0 1664800.0 False True 2034206.839465158 2239967.4902931503 2012901.982834505 1.0 1.1011503092193375 0.9895267009149106 20.956034950141543 -6.668114651424125 1.9441665007766282 1.0646690192371302 0.9899826541356034 0.27065719850648395 0.042985366803848846 0.4654721686571269 3.3901257183596463 0.017811688673709393 0.04770375687335165 2.1472635331925855e-07 6.668114651424125 -0.07468636510152682 MKGDVVVSLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MKGDVVVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 21052900.0 4869900.0 11219000.0 4964000.0 False True 6304181.55008041 10594652.787706394 4060602.9349412126 1.0 1.680575456709564 0.6441126263074418 22.587877651965734 -6.729590613065632 1.7246940985916779 1.4097694293548773 0.6447823474211123 0.5572798692613381 0.28610951700552234 0.33705834631460935 1.9640015518653378 0.13146957577216506 0.3263877084832513 1.8638432574199943e-07 6.729590613065632 -0.764987081933765 MKIELFADVVPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MKIELFADVVPK 12 1 C9JQD4;O43447;A6NM32 C9JQD4 PPIH Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase H 0 11819200.0 2166300.0 4336100.0 5316800.0 False True 3286435.477743858 3562289.0768960644 4265932.149563774 1.0 1.0839370196129883 1.2980422644695708 21.648092230365332 -6.9550292555064015 0.5005975022631057 0.995734256022598 1.3954889419630865 0.9995391320072328 0.002693859617863688 0.08152693245145365 0.028074681658608706 0.0031556636692260972 0.017662110404728322 1.1091001001109697e-07 6.9550292555064015 0.39975468594048846 MKLDYILGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MKLDYILGLK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 0 56441000.0 18235000.0 17143000.0 21063000.0 False True 23906261.587991167 14585331.222890608 18883602.810562804 1.0 0.6101050626090889 0.789901956901894 24.510885206216432 -10.06601093403119 4.751973528064282 1.0000099388674906 0.7000035097503189 0.7877754071545551 0.07340177474664232 101844068.77934934 7.998772245602012 12185.665666801637 0.025127379865364438 8.589918947917382e-11 10.06601093403119 -0.3000064291171717 MKLDYILGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MKLDYILGLK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 0 42125000.0 15499000.0 14294000.0 12332000.0 False True 15006992.728723673 20001668.74222529 9101879.247930085 1.0 1.3328232447225559 0.6065092062388298 23.839131566550925 -6.782096362520153 1.527483971372807 1.187942058855843 0.6003516683292791 0.7747883748333568 0.14087977052999276 0.24734252650054844 1.139970016475134 0.07262888397477747 0.17109158089224452 1.6515952968122282e-07 6.782096362520153 -0.5875903905265638 MKLDYILGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MKLDYILGLK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 0 95883000.0 22406000.0 35081000.0 38396000.0 False True 33991540.09801452 28820521.46089599 30807013.770435333 1.0 0.8478733643074744 0.9063141499797711 25.018672393594276 -10.776835009857814 9.47149505234498 1.0009459492561994 0.8770937574120325 0.8550160972433355 0.023858350844080153 0.00048003747072243266 1.1310491251254948e-05 0.023268710710690473 0.00770024962392467 1.6717255886621876e-11 10.776835009857814 -0.12385219184416685 MKLDYILGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MKLDYILGLK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 0 57215000.0 18235000.0 13239000.0 25741000.0 False True 24976972.28234596 12654057.20448151 19661505.952535987 1.0 0.5066289485145307 0.7871853213543015 24.574095267739324 -10.182735408760886 5.5497624328660935 1.000010286428595 0.6469071349343861 0.6786544158418839 0.11453665959068958 1.4578023813788144e-05 2.1467239078772264e-06 0.11090287259243899 0.0369665479270646 6.565451405645598e-11 10.182735408760886 -0.3531031514942088 MKLDYILGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MKLDYILGLK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 0 32560500.0 15499000.0 6873500.0 10188000.0 False True 12888105.222119315 6836471.091217067 12318263.6960103 1.0 0.5304481126895145 0.9557854691369978 23.6195368419852 -10.3890796541434 8.618497739141457 1.0000013948262063 0.7431167909132562 0.3272080113775043 0.17364324864010378 4.653876356828934e-06 3.2993824058386915e-07 0.16813026435301567 0.05604311751370629 4.082445031604707e-11 10.3890796541434 -0.2568846039129501 MKLDYILGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MKLDYILGLK 10 1 P46781;B5MCT8;C9JM19 P46781 RPS9 40S ribosomal protein S9 0 105085000.0 22406000.0 51395000.0 31284000.0 False True 29005008.688289672 48534823.07016403 25590633.00094703 1.0 1.6733255828935236 0.882283238593852 24.789798715686725 -6.681263518630805 1.8978703954206952 1.4255418714180346 0.8852956723355564 0.3297820321855569 0.2852931927786683 0.4356780608840179 3.0352489407479073 0.1205861335684143 0.3174689737963279 2.0832264517290294e-07 6.681263518630805 -0.5402461990824782 MKLPQFGISTPGSDLHVNAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MKLPQFGISTPGSDLHVNAK 20 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9323700.0 3151700.0 3193200.0 2978800.0 False True 4131909.2211062177 2716787.006996108 2670582.350667261 1.0 0.6575137210465517 0.6463313223402033 21.978377127569125 MKLPQFGISTPGSDLHVNAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MKLPQFGISTPGSDLHVNAK 20 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7183200.0 1696700.0 1863200.0 3623300.0 False True 1642839.1872266247 2607185.476459643 2674249.0333299614 1.0 1.5869998090689503 1.6278215507170373 20.647759835281438 -11.456228995964437 0.44247974649611227 2.1257749985454454e-07 1.6283995884649713 0.9997535846445204 0.004502399599317613 3.921098057337433 0.21910001986413646 3.7798637272211018 0.009366406008032048 3.4976069563647024e-12 11.456228995964437 1.6283993758874715 MKLPQFGISTPGSDLHVNAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MKLPQFGISTPGSDLHVNAK 20 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 26112600.0 8472700.0 8630800.0 9009100.0 False True 12853705.337340344 7090566.307251808 7228447.436171189 1.0 0.551635977421509 0.5623629332136908 23.61568096925196 -9.937254739380357 5.10896837242547 1.0000016365597448 0.5569994553265054 0.99956044265175 0.004379261386950742 5998450.43031897 0.0004688265248127654 116.26755111532724 0.0014991376507892198 1.1554343128782814e-10 9.937254739380357 -0.4430021812332394 MKLPQFGISTPGSDLHVNAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MKLPQFGISTPGSDLHVNAK 20 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 10809500.0 3151700.0 3085700.0 4572100.0 False True 4316968.661489986 2949363.570954645 3492264.1453552595 1.0 0.6832024511238132 0.8089621257871067 22.041587189092017 -10.206956518989431 4.827745826985266 1.000037677330884 0.7460822884547943 0.8446126469335474 0.051341172192877635 2.0823640154404143e-05 3.4206413762802117e-06 0.04971824378443079 0.016570292072821825 6.209311979590831e-11 10.206956518989431 -0.2539553888760896 MKLPQFGISTPGSDLHVNAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MKLPQFGISTPGSDLHVNAK 20 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 27579600.0 8472700.0 9546200.0 9560700.0 False True 10968077.171885746 9014945.57821579 7820750.701066159 1.0 0.8219257976524474 0.7130466515236539 23.38680729134441 MKPILLQGHER ddPTM_RPMI8226_Bortezomib_1h_R1 1 MKPILLQGHER 11 1 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 4912090.0 681290.0 2143600.0 2087200.0 False True 893177.7876217446 1823783.2356873571 1871236.5658361453 1.0 2.0419039310678855 2.0950325811602055 19.768587847757495 -10.928458084362775 0.5293482196170978 5.0277071606738713e-23 2.091381680821704 0.9998184034651627 0.006793776986161129 2.6788129103290723 0.2574421428234358 3.3163993784458845 0.01025305890185253 1.1790763155029185e-11 10.928458084362775 2.091381680821704 MKPILLQGHER ddPTM_RPMI8226_Bortezomib_2h_R1 1 MKPILLQGHER 11 1 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 3973990.0 1446900.0 532390.0 1994700.0 False True 1400968.951493016 744976.1033771732 1472228.230282693 1.0 0.5317577542194996 1.050864281263147 20.41799355219968 -6.669137855473226 1.940941509889384 0.7008899409439949 1.0487337218549064 0.27500456407674756 0.19894085949301962 0.46310596662455406 3.3628234000596007 0.08255015688344143 0.2207603759347841 2.1422105042498983e-07 6.669137855473226 0.3478437809109115 MKPILLQGHER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MKPILLQGHER 11 1 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 5380490.0 681290.0 2407300.0 2291900.0 False True 933181.3241699747 2300937.5261234455 1750600.4231621625 1.0 2.4656917862881924 1.8759488406170661 19.831797909280386 -10.215789018430103 6.15006704762415 0.999982399380735 2.170820313452632 0.8401343934479162 0.24076154938337138 5.8105547509552486e-05 7.408451777219118e-06 0.23311985462359847 0.07770545593073934 6.084305068704759e-11 10.215789018430103 1.170837914071897 MKPLMGVIYVPLTDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MKPLMGVIYVPLTDK 15 1 A0A0A0MRJ6;P22061;P22061-2;F6S8N6;A0A3F2YNX8 A0A0A0MRJ6 PCMT1 Protein-L-isoaspartate O-methyltransferase;Protein-L-isoaspartate(D-aspartate) O-methyltransferase 0 8307100.0 1684200.0 4282800.0 2340100.0 False True 2208002.509816 3643822.9342236486 2097968.8998242468 1.0 1.6502802501466816 0.9501659941496523 21.074310381339277 -6.662717871528945 1.9629488274894837 1.4176258692798853 0.953049430829506 0.2473760722477597 0.2766933880165029 0.4780131111350306 3.543419856464001 0.11376234479111069 0.3068868278743172 2.1741130780107822e-07 6.662717871528945 -0.4645764384503793 MKPLMGVIYVPLTDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MKPLMGVIYVPLTDK 15 1 A0A0A0MRJ6;P22061;P22061-2;F6S8N6;A0A3F2YNX8 A0A0A0MRJ6 PCMT1 Protein-L-isoaspartate O-methyltransferase;Protein-L-isoaspartate(D-aspartate) O-methyltransferase 0 9604600.0 2680800.0 2898900.0 4024900.0 False True 2595699.471395727 4056445.88756379 2970657.945588208 1.0 1.562756371554296 1.144453731383188 21.3076919279211 -10.482803445153438 5.859607620776028 0.9996704285473552 1.353605051468742 0.48791058773615725 0.17077133774637576 0.0007359203729188058 6.49559310802642e-05 0.1654994586474128 0.05511621225843956 3.290004976327118e-11 10.482803445153438 0.3539346229213869 MKPLMGVIYVPLTDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MKPLMGVIYVPLTDK 15 1 A0A0A0MRJ6;P22061;P22061-2;F6S8N6;A0A3F2YNX8 A0A0A0MRJ6 PCMT1 Protein-L-isoaspartate O-methyltransferase;Protein-L-isoaspartate(D-aspartate) O-methyltransferase 0 10181300.0 1684200.0 4411900.0 4085200.0 False True 2306894.2537936443 4216967.669797718 3120359.8973349896 1.0 1.827984816756552 1.3526237243877202 21.13752044286217 -10.213583107014948 5.406967199652564 0.9999669678428672 1.5903042705722066 0.6727851143544569 0.19406535331286906 7.728132410965801e-05 1.1239534062162833e-05 0.18791345242660826 0.06263432345467919 6.115287690164447e-11 10.213583107014948 0.5903373027293394 MKPLMGVIYVPLTDKEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MKPLMGVIYVPLTDKEK 17 2 A0A0A0MRJ6;P22061;P22061-2;F6S8N6;A0A3F2YNX8 A0A0A0MRJ6 PCMT1 Protein-L-isoaspartate O-methyltransferase;Protein-L-isoaspartate(D-aspartate) O-methyltransferase 0 6736900.0 2106200.0 2789500.0 1841200.0 False True 2761248.596469814 2373317.473385839 1650690.2860375177 1.0 0.8595088020760119 0.5978057492352855 21.39688934958954 -6.961411096382878 0.4150718553746386 1.0122001471231707 0.4353217049813196 0.9998189971312175 0.0022422203795586003 0.0792008956791263 0.019297198181581852 0.003376198484176809 0.021815727573901576 1.0929213341881183e-07 6.961411096382878 -0.5768784421418511 MKPLMGVIYVPLTDKEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MKPLMGVIYVPLTDKEK 17 2 A0A0A0MRJ6;P22061;P22061-2;F6S8N6;A0A3F2YNX8 A0A0A0MRJ6 PCMT1 Protein-L-isoaspartate O-methyltransferase;Protein-L-isoaspartate(D-aspartate) O-methyltransferase 0 6922500.0 2106200.0 2494600.0 2321700.0 False True 2884919.057914841 2384380.323460953 1773362.2769124242 1.0 0.8264981705186325 0.6147008776718239 21.46009941111243 -6.968455391624244 0.2927560991194419 1.0400430147184092 0.39458727132245863 0.9999676918874792 0.0008955359620285273 0.07680731282002023 0.010815741915966638 0.0036463579401518165 0.019146279191879726 1.0753370475146751e-07 6.968455391624244 -0.6454557433959506 MKPLVVFVLGGPGAGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MKPLVVFVLGGPGAGK 16 1 P30085;P30085-2 P30085 CMPK1 UMP-CMP kinase 0 212842500.0 64746300.0 63425000.0 84671200.0 False True 84883026.30406104 53962237.228713624 75910236.44750156 1.0 0.6357247093831753 0.8942922955595635 26.338972757269467 -10.084810967774118 5.811428972565703 1.0000011284857817 0.7650085024713487 0.5240979416157805 0.10555977502595153 1.5433707319200827e-06 2.4320551397263655e-07 0.10220830306509987 0.034069270892065254 8.226006194729264e-11 10.084810967774118 -0.23499262601443305 MKPLVVFVLGGPGAGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MKPLVVFVLGGPGAGK 16 1 P30085;P30085-2 P30085 CMPK1 UMP-CMP kinase 0 229407600.0 93718700.0 74590100.0 61098800.0 False True 90743651.16752273 104374315.91223288 45095191.35528954 1.0 1.1502106711525906 0.49695147566895753 26.435293373440693 -6.846214652284387 1.253285465273554 1.0799666199628888 0.4726921878069993 0.934604110758717 0.07143919054417736 0.16167095397856415 0.49058771159283765 0.04464481042133331 0.10308742050912217 1.4249031538077146e-07 6.846214652284387 -0.6072744321558895 down MKPLVVFVLGGPGAGK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MKPLVVFVLGGPGAGK 16 1 P30085;P30085-2 P30085 CMPK1 UMP-CMP kinase 0 409363300.0 116412100.0 144781600.0 148169600.0 False True 176605666.5644947 118944192.29619607 118883813.61495736 1.0 0.6735015620393969 0.6731596778721827 27.395956393100796 MKPLVVFVLGGPGAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MKPLVVFVLGGPGAGK 16 1 P30085;P30085-2 P30085 CMPK1 UMP-CMP kinase 0 283444900.0 64746300.0 82222300.0 136476300.0 False True 88684756.8129672 78589446.9132139 104243408.75762722 1.0 0.8861663462522209 1.1754377246303176 26.402182818792358 -6.800006168784118 1.4563737274289699 0.9371930973197802 1.179409132287896 0.8320364036082585 0.04876358502858169 0.22075769999343428 0.924482318738442 0.026343527616220372 0.06125180336909505 1.5848706805597974e-07 6.800006168784118 0.24221603496811572 MKPLVVFVLGGPGAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MKPLVVFVLGGPGAGK 16 1 P30085;P30085-2 P30085 CMPK1 UMP-CMP kinase 0 169358500.0 93718700.0 29697000.0 45942800.0 False True 77931251.49236938 29537016.366607003 55549227.06449373 1.0 0.3790137563683179 0.7127978314313715 26.21569864887497 -10.627217782995034 6.723094961527229 1.0014154538556879 0.5459057938999196 0.711627760874278 0.1362667780285534 0.0028986752206531336 0.0001607255138776998 0.13228736955178824 0.04397991349549417 2.3592948353525622e-11 10.627217782995034 -0.4555096599557683 MKPLVVFVLGGPGAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MKPLVVFVLGGPGAGK 16 1 P30085;P30085-2 P30085 CMPK1 UMP-CMP kinase 0 359544000.0 116412100.0 142517800.0 100614100.0 False True 150697758.27555296 134586559.14678538 82303366.18784629 1.0 0.8930893245319016 0.5461485766586749 27.167082715193246 -6.949672643377218 0.562425509591005 1.0044812257008329 0.4181066251786206 0.9991753458710921 0.005563276973536554 0.08361745182057331 0.03650835879899265 0.00594619583959601 0.028855625570956292 1.1228645130277289e-07 6.949672643377218 -0.5863746005222124 MKVELCSFSGYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MKVELCSFSGYK 12 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 42108300.0 13444200.0 11470800.0 17193300.0 False True 17625476.39381798 9759401.352828195 15414302.245779313 1.0 0.5537099329837826 0.8745467016815375 24.071158916429937 -9.939291110797322 6.437519987076144 1.00000004244597 0.7141283173326494 0.5142219618420802 0.13098106233884652 7.985613157681101e-08 1.321016715776759e-08 0.12682188717459164 0.04227395609223673 1.1500292574245934e-10 9.939291110797322 -0.2858717251133207 MKVELCSFSGYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MKVELCSFSGYK 12 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 128806000.0 30506000.0 46064000.0 52236000.0 False True 46279832.2873351 37843519.30032531 41911531.70414791 1.0 0.8177108133272458 0.9056111405921708 25.463880300509395 -10.075351723678832 4.435519284944364 1.0000106893056584 0.8616609769484411 0.7675787657864063 0.03588515837265774 49836423.19343321 0.1300713813791896 5576.424528223705 0.012284444194936881 8.40713993708025e-11 10.075351723678832 -0.13834971235721727 MKVELCSFSGYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MKVELCSFSGYK 12 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 36387800.0 13444200.0 7945800.0 14997800.0 False True 18414884.055844013 7594728.282753173 11455628.529386735 1.0 0.4124233560049468 0.6220852922368121 24.13436897795283 -10.101564768225039 5.155575516990185 1.000011265947104 0.517254324120058 0.8760634939660661 0.08559412704488566 1.1084135624483748e-05 1.9317163043368823e-06 0.08287808957491792 0.027625385714419227 7.914714102483496e-11 10.101564768225039 -0.4827569418270461 MKVELCSFSGYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MKVELCSFSGYK 12 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 134912000.0 30506000.0 58659000.0 45747000.0 False True 39490618.36316005 55394575.0845948 37421515.40385889 1.0 1.4027274674501224 0.9476052023223982 25.235006622601844 -6.673128529208561 1.9259961403115509 1.2563571843896053 0.9494046585349132 0.2931371537044496 0.17094609227993116 0.45395261444159896 3.2492697892584332 0.07137450973882954 0.1899401286746741 2.1226161819656065e-07 6.673128529208561 -0.3069525258546921 MKYPHLVAGALAASAPVLAVAGLGDSNQFFR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MKYPHLVAGALAASAPVLAVAGLGDSNQFFR 31 1 Q9UHL4 Q9UHL4 DPP7 Dipeptidyl peptidase 2 0 279858000.0 115394000.0 59707000.0 104757000.0 False True 175061134.4314151 49051819.3570798 84051733.03337587 1.0 0.28019822627333174 0.4801278896447766 27.383283583665246 -10.669423866556986 7.50766722799734 1.0020437221550138 0.3801630579595044 0.9276180911408349 0.08162094328440797 0.0027978052665353238 0.00012319211432814192 0.07919072308186503 0.026343046170187692 2.140800184138183e-11 10.669423866556986 -0.6218806641955095 MKYPHLVAGALAASAPVLAVAGLGDSNQFFR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MKYPHLVAGALAASAPVLAVAGLGDSNQFFR 31 1 Q9UHL4 Q9UHL4 DPP7 Dipeptidyl peptidase 2 0 200160600.0 115394000.0 46537000.0 38229600.0 False True 149379807.75580195 43947175.04068931 31272205.068821263 1.0 0.29419756057345975 0.20934693609957897 27.154409905757696 -13.999999999999998 0.2988541451270499 7.39589049639786 0.18822054699882965 0.9996472734344035 0.00665626851809301 16.514153378518394 0.17358284859179254 65.27012576903532 0.030816309052460036 1.0000000000000041e-14 13.999999999999998 -7.207669949399031 MLAAK(ub)SADGSAPAGEGEGVTLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLAAKSADGSAPAGEGEGVTLQR 23 1 Q01650 Q01650 SLC7A5 Large neutral amino acids transporter small subunit 1 1 30770600.0 8430600.0 11862000.0 10478000.0 True False 11052598.242046526 10092235.83771386 9393837.072073178 1.0 0.9131098061015884 0.8499211557638047 23.39788222208944 -6.974594025288153 0.09926456455909535 1.1580527571632497 0.6033762331789839 0.9999997442035125 3.057605830703491e-05 0.07483846184997898 0.0029124189073279037 0.005758216111597602 0.010413998235051725 1.0602443693155051e-07 6.974594025288153 -0.5546765239842658 MLAAK(ub)SADGSAPAGEGEGVTLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MLAAKSADGSAPAGEGEGVTLQR 23 1 Q01650 Q01650 SLC7A5 Large neutral amino acids transporter small subunit 1 1 39400800.0 10093000.0 7356800.0 21951000.0 True False 9772603.23962887 10294408.605205182 16201374.584115574 1.0 1.0533947150806593 1.6578361145797265 23.220311489822507 -6.924251715065891 0.7925472020951674 0.9885941883941347 1.7655259232112666 0.9952829746349291 0.02048873753858774 0.09573410271225488 0.0931183174849263 0.018063096046839446 0.05651817975980554 1.1905517697375655e-07 6.924251715065891 0.7769317348171318 MLAAK(ub)SADGSAPAGEGEGVTLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLAAKSADGSAPAGEGEGVTLQR 23 1 Q01650 Q01650 SLC7A5 Large neutral amino acids transporter small subunit 1 1 82492000.0 11397000.0 31691000.0 39404000.0 True False 17290082.232307028 26035493.44708686 31615782.128613267 1.0 1.505805067742175 1.828550130868565 24.043441394722063 -8.802658548370324 0.10850349509991368 3.5952590112923388e-09 2.7327799993235224 0.9999591102208357 0.002180489012596756 0.3302460559043031 0.03189979200747193 0.43092198933710857 0.3328432095672086 1.5752208501302627e-09 8.802658548370324 2.7327799957282632 MLAAK(ub)SADGSAPAGEGEGVTLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLAAKSADGSAPAGEGEGVTLQR 23 1 Q01650 Q01650 SLC7A5 Large neutral amino acids transporter small subunit 1 1 29520900.0 8430600.0 5484300.0 15606000.0 True False 11547620.648398459 5241985.491845148 11920184.215658914 1.0 0.45394507244850996 1.0322632322799872 23.46109228361233 -10.121294623996006 13.653140790825429 1.0000046045704059 0.7431041523642485 0.20829643842017187 0.2360974001103747 0.0 0.0 0.22860032467082478 0.07620010822360823 7.563196361070736e-11 10.121294623996006 -0.2569004522061573 MLAAK(ub)SADGSAPAGEGEGVTLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MLAAKSADGSAPAGEGEGVTLQR 23 1 Q01650 Q01650 SLC7A5 Large neutral amino acids transporter small subunit 1 1 29035100.0 10093000.0 6789100.0 12153000.0 True False 8392776.695712633 6752525.770769163 14694136.110876845 1.0 0.8045639739490059 1.7508074673764642 23.000716765256783 -6.852844176908193 1.2212349498406427 0.8953946414889316 1.790773073608983 0.9443497072200359 0.09621982003601717 0.15435551172093415 0.44156165307282685 0.06160310967697433 0.1428415456615799 1.4033171187134462e-07 6.852844176908193 0.8953784321200515 MLAAK(ub)SADGSAPAGEGEGVTLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MLAAKSADGSAPAGEGEGVTLQR 23 1 Q01650 Q01650 SLC7A5 Large neutral amino acids transporter small subunit 1 1 61783000.0 11397000.0 22980000.0 27406000.0 True False 14753641.16845654 21701142.7989565 22418389.209306788 1.0 1.4709008136482131 1.519515687912864 23.814567716814512 -11.757043734513204 0.36964467346167934 1.3432668685309872e-19 1.5252188179668194 0.9996246232905762 0.004539195009533257 4.653983192421425 0.19010395684190606 3.6560509891330395 0.013589635328980438 1.749670483669004e-12 11.757043734513204 1.5252188179668194 MLAQQAVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 MLAQQAVKR 9 1 P04844;P04844-2;Q5JYR3 P04844 RPN2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 1 12389300.0 2465400.0 2916000.0 7007900.0 True False 2387137.226491731 4080374.006739116 5172320.757506425 1.0 1.709316901205491 2.166746301848743 21.18685007260544 -8.52678494294498 0.13432488638778692 1.0226845931656194e-16 3.151984250509568 0.9999304191736916 0.00400398837844624 0.16714069786232263 0.0340988332727495 0.39366967111666457 0.33994230325734587 2.973137927029346e-09 8.52678494294498 3.151984250509568 MLAQQAVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MLAQQAVKR 9 1 P04844;P04844-2;Q5JYR3 P04844 RPN2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 1 11078300.0 2465400.0 3117500.0 5495400.0 True False 2050089.3357386254 3100705.4087246996 6644462.732141244 1.0 1.5124733125873993 3.2410600925092443 20.967255348039718 -6.94879051359057 0.5719669138683706 0.9786539594023677 3.8592065964964637 0.9991029259521219 0.028716015013556247 0.0839750592947145 0.03800045009060976 0.03035505172817022 0.14409553017725024 1.1251475695938078e-07 6.94879051359057 2.880552637094096 MLDAK(ub)EQEMTEMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MLDAKEQEMTEMR 13 1 Q03252 Q03252 LMNB2 Lamin-B2 1 3768500.0 1371500.0 1094700.0 1302300.0 True False 1327962.483221145 1531819.4187850861 961188.5618374443 1.0 1.1535110653649339 0.7238070156213727 20.34078295845227 -6.810099635210484 1.4140217950295582 1.083653877276896 0.7162660821111558 0.8601014703961276 0.06650000964892301 0.20667040750984764 0.814406032390106 0.03697802164099405 0.08553759924262472 1.5484613324051534e-07 6.810099635210484 -0.36738779516574016 MLDAK(ub)EQEMTEMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLDAKEQEMTEMR 13 1 Q03252 Q03252 LMNB2 Lamin-B2 1 2669140.0 779590.0 815750.0 1073800.0 True False 1067825.4906275903 779707.4676754874 820190.5556051873 1.0 0.730182482548934 0.7680941902998952 20.026244463187382 -10.760901212159506 10.445032981472151 1.000798067404136 0.7491383364623189 0.9831591789189879 0.015477389877895495 0.0002884489082981816 6.602909336689412e-06 0.015028062187571578 0.004995306103320707 1.7341984265151727e-11 10.760901212159506 -0.25165973094181704 MLDAK(ub)EQEMTEMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MLDAKEQEMTEMR 13 1 Q03252 Q03252 LMNB2 Lamin-B2 1 10359100.0 1801800.0 4283600.0 4273700.0 True False 2332465.61878784 4045213.8944129725 3495930.451865084 1.0 1.7343080480282627 1.4988132831222118 21.153424384819278 -10.146164918216915 4.817359927847882 0.9999524955479043 1.6165606655785807 0.9013769155083564 0.09614033519762133 4.905630145381152e-05 8.694827371494221e-06 0.09309462456237814 0.03102915975829161 7.142250560159233e-11 10.146164918216915 0.6166081700306764 MLDEK(ub)TPPSPSGQPEEPGMVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLDEKTPPSPSGQPEEPGMVR 21 1 M0R2P6;Q8TBC3;M0R0S1;M0QXA4;Q8TBC3-2 M0R2P6 SHKBP1 SH3KBP1-binding protein 1 1 23744900.0 3793400.0 5614500.0 14337000.0 True False 5754865.1346875075 4612548.608711281 11503285.665869674 1.0 0.8015042057039874 1.9988801469096997 22.456350688507506 -6.864324267927917 1.1637934580127216 0.8908103872743298 2.0618108905604777 0.9586775532051208 0.10651157809812228 0.14240770560112048 0.36409907639731803 0.07124974877132155 0.1672025217795221 1.36670798587231e-07 6.864324267927917 1.171000503286148 MLDEK(ub)TPPSPSGQPEEPGMVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MLDEKTPPSPSGQPEEPGMVR 21 1 M0R2P6;Q8TBC3;M0R0S1;M0QXA4;Q8TBC3-2 M0R2P6 SHKBP1 SH3KBP1-binding protein 1 1 23505400.0 3793400.0 7433000.0 12279000.0 True False 4910631.079093014 7019347.0158678675 10044347.993179515 1.0 1.4294185213286945 2.045429157963683 22.227477010599955 -6.965988330388904 0.34066376549619687 0.933696474856492 2.561643556854017 0.9999320928783969 0.0035356539793891585 0.07762715719371076 0.0136861571916709 0.008678306732703138 0.05329253058420612 1.0814630101133621e-07 6.965988330388904 1.6279470819975248 up MLDGPLFSEGPDSPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MLDGPLFSEGPDSPR 15 0 O94850 O94850 DDN Dendrin 0 14349800.0 4032500.0 5678100.0 4639200.0 False True 5220150.742458632 5362108.743548955 3794913.202211779 1.0 1.027194234054525 0.7269738728702723 22.31566003747134 -6.884773527124487 1.0527663707573276 1.0182094738259508 0.7036451087607829 0.9773383207272611 0.020408556734797818 0.1234879368980005 0.247419627648363 0.014862539860878229 0.03642111519699911 1.303846522047817e-07 6.884773527124487 -0.31456436506516794 MLDLLEDFLEHEGYK(ub)YER ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLDLLEDFLEHEGYKYER 18 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y8B3 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 16229600.0 4072400.0 7562300.0 4594900.0 True False 6178128.532319663 6212748.480480412 3686716.0009837863 1.0 1.0056036302870104 0.5967366948902822 22.55873845502123 -6.903793207852385 0.9369689254926351 1.0152756349185779 0.5503527436466192 0.9883609966725617 0.020652770602811055 0.10866700269085654 0.16208849103954953 0.016406092116360977 0.04355875818215452 1.2479776054607344e-07 6.903793207852385 -0.4649228912719586 MLDLLEDFLEHEGYK(ub)YER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MLDLLEDFLEHEGYKYER 18 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y8B3 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 13343700.0 4072400.0 3474200.0 5797100.0 True False 5271802.079005218 3280857.7159327534 4742087.283269081 1.0 0.6223408365421501 0.8995192179452812 22.32986477711368 -10.47331968912556 5.4772398864631 1.000311724276706 0.760930027243715 0.49796803215482377 0.11315760036137164 0.0004312976122437978 4.14725663549527e-05 0.10970553621216071 0.036521458474698475 3.3626395051674055e-11 10.47331968912556 -0.23938169703299095 MLDMGFEPQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLDMGFEPQIR 11 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-2;O15523;A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A2R8YCW1;O15523-2;A0A1X7SBZ2;J3KTA4 DDX3X;DDX3Y;DDX17;DDX5 ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y;Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 19857000.0 4952500.0 5660300.0 9244200.0 False True 6492775.460078226 4815805.303676592 8287698.860627865 1.0 0.7417175186924715 1.2764493261142307 22.63040388676981 -6.7753654503970475 1.553785525005771 0.8528682805798578 1.2800938612060446 0.7506470639762404 0.10903129347349864 0.25787079289766635 1.2292839336748218 0.055285778251561765 0.13097332168376838 1.6773919312540837e-07 6.7753654503970475 0.4272255806261869 MLDMGFEPQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLDMGFEPQIR 11 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-2;O15523;A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A2R8YCW1;O15523-2;A0A1X7SBZ2;J3KTA4 DDX3X;DDX3Y;DDX17;DDX5 ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y;Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 18370800.0 4952500.0 7705000.0 5713300.0 False True 6783573.086280152 7364567.62297227 4363936.209107016 1.0 1.0856472730967084 0.6433093818850604 22.6936139482927 -6.8564978437011295 1.2032685959832947 1.046103166499789 0.6232749134352604 0.949243416874397 0.04315497474403194 0.15045367791913164 0.4159327339344549 0.02800943904781485 0.06514730245433832 1.3915607040121843e-07 6.8564978437011295 -0.42282825306452865 MLDSGADYLHLDVMDGHFVPNITFGHPVVESLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLDSGADYLHLDVMDGHFVPNITFGHPVVESLR 33 0 C9J9T0;C9IZU8;Q96AT9-4;Q96AT9 C9J9T0 RPE Ribulose-phosphate 3-epimerase 0 30345500.0 9991600.0 6658900.0 13695000.0 False True 15157987.683804419 5470567.268776829 10988177.247268273 1.0 0.3609032665082495 0.724910026085363 23.853574903782967 -10.708178016578167 6.9682377452626705 1.0042317494532378 0.5429066462969546 0.6776760958667718 0.148605137314647 0.009814806203475586 0.0004110328234814376 0.1445514978635186 0.047962101831707855 1.9580419109035214e-11 10.708178016578167 -0.46132510315628317 MLEHLSSLPTQMDYK(ub)GQK ddPTM_RPMI8226_Bortezomib_1h_R1 3 MLEHLSSLPTQMDYKGQK 18 1 A0A5F9YFS9 A0A5F9YFS9 1 312745900.0 35435700.0 47217600.0 230092600.0 True False 46456545.85980691 40172918.132763274 206284824.95607045 1.0 0.8647418224763008 4.4403823215479985 25.46937855498803 -6.898108605725741 0.9731591994887854 0.8435249332656947 4.801601939267829 0.9856012475972704 0.19854509008038493 0.11281052338453926 0.18538079173738545 0.15354673187890505 0.39583807520298053 1.2644201094316076e-07 6.898108605725741 3.958077006002134 up MLEHLSSLPTQMDYK(ub)GQK ddPTM_RPMI8226_Bortezomib_2h_R1 3 MLEHLSSLPTQMDYKGQK 18 1 A0A5F9YFS9 A0A5F9YFS9 1 363320600.0 27828700.0 49978100.0 285513800.0 True False 26945293.151160225 69934615.96234849 210729170.54959938 1.0 2.595429768383767 7.820630095483882 24.68352994681689 -6.949463269941666 0.5647047887273865 0.9332704280923227 9.734535535628671 0.9991584917531562 0.08450196260156452 0.08370197118434007 0.03685977427909171 0.09007507107962054 0.4348136562364984 1.1234059766890219e-07 6.949463269941666 8.801265107536349 MLEHLSSLPTQMDYK(ub)GQK ddPTM_RPMI8226_Bortezomib_8h_R1 3 MLEHLSSLPTQMDYKGQK 18 1 A0A5F9YFS9 A0A5F9YFS9 1 623697000.0 30950300.0 336811700.0 255935000.0 True False 46953867.87001598 276705020.61317676 205349335.0697043 1.0 5.893125170841918 4.373427459441253 25.484740670377043 -9.688681781430235 7.806160553868068 1.0000049117326633 5.13327557854804 0.907945199675781 0.6204139927080503 3.69557998171467e-09 0.0 0.6007132474729372 0.2002377551251663 2.0479446680451527e-10 9.688681781430235 4.133270666815377 MLEHLSSLPTQMDYK(ub)GQK ddPTM_RPMI8226_Carfilzomib_1h_R1 3 MLEHLSSLPTQMDYKGQK 18 1 A0A5F9YFS9 A0A5F9YFS9 1 477277500.0 35435700.0 47897800.0 393944000.0 True False 48537235.90378542 45781516.81915659 300902540.7313557 1.0 0.9432246391184811 6.199416491862659 25.53258861651092 -6.904457452191436 0.9326418054960368 0.8073811773024918 6.803966088026058 0.9886568479526121 0.26248176554611974 0.10819870666690452 0.15948691728853315 0.20917421090546834 0.5574858712035983 1.2460703087364998e-07 6.904457452191436 5.996584910723566 up MLEHLSSLPTQMDYK(ub)GQK ddPTM_RPMI8226_Carfilzomib_2h_R1 3 MLEHLSSLPTQMDYKGQK 18 1 A0A5F9YFS9 A0A5F9YFS9 1 347851300.0 27828700.0 88531900.0 231490700.0 True False 23140797.070442714 88054961.08249377 279894335.07793576 1.0 3.8051827175376185 12.095276330625591 24.463935222251166 -6.951787887218291 0.5388587768589015 0.8770238247328603 15.405523917678059 0.9993342209291695 0.12154376728866215 0.08277567548209264 0.03305198768665775 0.1338948374071175 0.6864135129288483 1.1174088656543796e-07 6.951787887218291 14.528500092945198 MLEHLSSLPTQMDYK(ub)GQK ddPTM_RPMI8226_Carfilzomib_8h_R1 3 MLEHLSSLPTQMDYKGQK 18 1 A0A5F9YFS9 A0A5F9YFS9 1 520704800.0 30950300.0 240566200.0 249188300.0 True False 40065773.47162239 227178479.49531448 203838586.28787494 1.0 5.67013837025309 5.087598931098855 25.255866992469493 -10.475480437389223 5.0067651396890085 0.989643453236888 5.378868650676031 0.9869002992543484 0.23782073016321734 0.027166649066895532 0.0028460340563358855 0.22753442825501605 0.07675631060864893 3.345950892077672e-11 10.475480437389223 4.389225197439143 MLELVAQK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLELVAQKQR 10 1 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 198423000.0 80072000.0 67176000.0 51175000.0 True False 104975167.41835101 57153602.649997056 45879901.905262865 1.0 0.5444487877997504 0.437054810519335 26.645472848138056 -13.999999999999998 0.2029958593510395 3.5617258139937915 0.36933151565761735 0.9994873031384554 0.005525583298994757 12.591730909549385 0.14284833184252674 12.823790082497029 0.06688626065466756 1.0000000000000041e-14 13.999999999999998 -3.192394298336174 MLELVAQK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MLELVAQKQR 10 1 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 293495500.0 127052100.0 75653900.0 90789500.0 True False 123018900.6303035 105862896.79987663 67009006.323382206 1.0 0.860541723730859 0.5447049679362501 26.87430474743402 -6.957542883343561 0.46878029818298783 1.0084417592356774 0.38388371547423694 0.9996679346410228 0.00347078906421019 0.08059080180813903 0.02446497048300203 0.004357017176066314 0.02607009090153893 1.1026993451310669e-07 6.957542883343561 -0.6245580437614404 MLELVAQK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MLELVAQKQR 10 1 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 547747900.0 154828000.0 173405300.0 219514600.0 True False 234885395.4429793 142459769.39320707 176127443.09333277 1.0 0.6065075656344524 0.749844164475051 27.807381772248878 -10.254371387378454 4.683933950189634 1.0001034963112312 0.6781758650538993 0.8704903323186355 0.05851692144121201 6.32960048771668e-05 1.0076071689954e-05 0.05667692372245778 0.018886255183914326 5.5670947463075996e-11 10.254371387378454 -0.3219276312573319 MLELVAQK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MLELVAQKQR 10 1 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 260010300.0 88348500.0 88934600.0 82727200.0 True False 121013327.97843954 85005175.30460608 63188739.180165246 1.0 0.7024447366636435 0.5221634693942417 26.850590708660732 -9.740470838147496 0.09877338955407655 1.7506379712660445 2.4735290364592477e-10 0.9999431335393439 0.001485748376967294 1.2554128502157758 0.04247552428408168 0.49857274566407156 0.25768138669710766 1.817729108229941e-10 9.740470838147496 -1.7506379710186917 MLELVAQK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MLELVAQKQR 10 1 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 310307300.0 127052100.0 114989300.0 68265900.0 True False 105649450.51237023 114369829.81731114 82539984.0641411 1.0 1.0825406972080736 0.7812627861654301 26.654710022868297 -6.83367119068045 1.3112979882164908 1.044006580591725 0.7725231978058067 0.9130365040595919 0.03748609735160191 0.17632829649326065 0.5916430085175072 0.02243543435636778 0.051636115454213906 1.4666578441337265e-07 6.83367119068045 -0.2714833827859182 MLELVAQK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MLELVAQKQR 10 1 Q04323;E9PJ81;E9PRQ7;Q04323-2 Q04323 UBXN1 UBX domain-containing protein 1 1 594463500.0 154828000.0 230681600.0 208953900.0 True False 200427898.1161526 217843966.1745763 170926434.24806872 1.0 1.086894430476593 0.8528075974184636 27.578508094341327 -6.806166982110771 1.4303544510047665 1.047575252770128 0.8490526222911964 0.8496543258679785 0.03746253603229126 0.21206495468371944 0.8557619881430457 0.020597523810039604 0.04773937680931139 1.5625467427200361e-07 6.806166982110771 -0.1985226304789317 MLFDYLADK(ub)HGFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLFDYLADKHGFR 13 1 P60228;E5RGA2;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 11700800.0 4769600.0 4763400.0 2167800.0 True False 6252991.788872099 4052719.2875877717 1943496.8510059384 1.0 0.6481248375857523 0.31081071535462584 22.576115192096765 -7.42430478952041 0.27719100019200116 1.1015054177029064 5.884239059620394e-13 0.999839717837496 0.0035623552414957927 0.1194139854086503 0.024435876042981215 0.020252193513013796 0.05895318633054067 3.76439519570969e-08 7.42430478952041 -1.101505417702318 down MLFDYLADK(ub)HGFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLFDYLADKHGFR 13 1 P60228;E5RGA2;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 75337700.0 8625600.0 14452100.0 52260000.0 True False 13085665.815827614 11873009.840227302 41930788.09362828 1.0 0.9073294402694009 3.2043297363525354 23.641483996679618 -6.897496604924784 0.9769375197689752 0.8978293532026516 3.4335641864465534 0.9852797755609192 0.1288064914244807 0.11327228201059886 0.18798495497701437 0.09933118072840406 0.255350454700799 1.266203165951663e-07 6.897496604924784 2.535734833243902 up MLFDYLADK(ub)HGFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLFDYLADKHGFR 13 1 P60228;E5RGA2;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 15715200.0 4769600.0 5248100.0 5697500.0 True False 6533050.013593493 5016221.588854099 4351867.843695806 1.0 0.7678223155213433 0.6661311079267352 22.639325253619656 -13.999999999999998 0.11219247546034695 2.116286582064184 0.48533531261143165 0.9997319428476443 0.002287687695847279 12.000186145736839 0.10199287849379732 3.0224420210684504 0.16050808656514196 1.0000000000000041e-14 13.999999999999998 -1.6309512694527524 MLFDYLADK(ub)HGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MLFDYLADKHGFR 13 1 P60228;E5RGA2;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 18024400.0 6490400.0 8603100.0 2930900.0 True False 5397055.173472037 8556753.392718362 3543737.6390495263 1.0 1.5854485673552279 0.6566057831811578 22.36374100521498 -6.736365972156645 1.7001510572623901 1.3498066631012842 0.6564999215156507 0.5884193686051006 0.24601116378480328 0.32444923205777826 1.8399896956106896 0.1145428576855861 0.2821906690416787 1.8349913773764578e-07 6.736365972156645 -0.6933067415856334 MLFDYLADK(ub)HGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MLFDYLADKHGFR 13 1 P60228;E5RGA2;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 88178300.0 8625600.0 14683700.0 64869000.0 True False 11166009.235995313 13866539.186990336 53063507.61214772 1.0 1.241852742006469 4.752235690535658 23.412610318772067 -6.9208323758831 0.81853517209402 0.9248451929615016 5.329287914379427 0.9944089182472148 0.12821124912556736 0.0976844563019491 0.10309633341674161 0.11095671570219376 0.3350565988695012 1.1999623618047278e-07 6.9208323758831 4.404442721417926 up MLFYSFFK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MLFYSFFK 8 0 Q9Y333 Q9Y333 LSM2 U6 snRNA-associated Sm-like protein LSm2 0 12371650.0 3800380.0 5189870.0 3381400.0 False True 4982334.982932271 4415561.625954812 3031525.164679159 1.0 0.8862434262411047 0.6084547054873064 22.248390592502364 -6.955963266668103 0.4890193805077039 1.0061335703396135 0.47680467974840524 0.9995899446219292 0.003330219680798502 0.08117593914745591 0.02670909178421563 0.003991158700685014 0.022911217354790944 1.1067173879712804e-07 6.955963266668103 -0.5293288905912082 MLFYSFFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MLFYSFFK 8 0 Q9Y333 Q9Y333 LSM2 U6 snRNA-associated Sm-like protein LSm2 0 12555000.0 7811700.0 2705400.0 2037900.0 False True 7563721.859408388 3785680.328474621 1504112.8543104716 1.0 0.5005049628795745 0.19885882668193708 22.850664881391584 -8.530359277416844 0.26720034923151237 1.217917500510099 5.3763844683802863e-20 0.9991634358589752 0.0095554953174238 0.17911854608027686 0.07258649093893975 0.1344214838084737 0.105671068331088 2.948768798763373e-09 8.530359277416844 -1.217917500510099 down MLFYSFFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLFYSFFK 8 0 Q9Y333 Q9Y333 LSM2 U6 snRNA-associated Sm-like protein LSm2 0 29731100.0 7884100.0 10409000.0 11438000.0 False True 11960756.104916362 8551432.624111788 9177274.286546513 1.0 0.7149575285292206 0.7672821187929981 23.511805257287175 -10.576696873076022 6.3933461281554935 1.000509067519461 0.7411198236611111 0.9702717886325186 0.02136142452440928 0.00015529749592714165 1.0282229697065583e-05 0.020722617782414063 0.006894370119525314 2.6503493721965254e-11 10.576696873076022 -0.25938924385834994 MLFYSFFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLFYSFFK 8 0 Q9Y333 Q9Y333 LSM2 U6 snRNA-associated Sm-like protein LSm2 0 16405000.0 3489500.0 6652000.0 6263500.0 False True 4779662.450191742 6358092.644777624 4784190.300831707 1.0 1.330238842394103 1.0009473159845803 22.188477304971652 -10.751371099712204 9.611678695729694 0.9993250041945216 1.1655930791893414 0.25215760489941597 0.1344327027209236 0.0019519893736138498 5.049261425127568e-05 0.13066542118369254 0.04338796823531581 1.7726741036171457e-11 10.751371099712204 0.16626807499481977 MLFYSFFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MLFYSFFK 8 0 Q9Y333 Q9Y333 LSM2 U6 snRNA-associated Sm-like protein LSm2 0 13158600.0 7811700.0 3584400.0 1762500.0 False True 6495774.66698686 3565090.125752304 2131030.6011207467 1.0 0.548832172992542 0.3280641201966523 22.63107015682586 -10.72409742482601 0.1428100241812312 1.9126348698374918 4.72663706122905e-18 0.9997154536549621 0.004717110952571846 2.702099345930101 0.07875942201331339 1.0527737243356639 0.21621321901040064 1.8875678654770524e-11 10.72409742482601 -1.9126348698374918 MLFYSFFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MLFYSFFK 8 0 Q9Y333 Q9Y333 LSM2 U6 snRNA-associated Sm-like protein LSm2 0 56615100.0 7884100.0 25434000.0 23297000.0 False True 10206122.868845148 24018575.54171712 19057185.04740639 1.0 2.3533496363281476 1.8672306116928774 23.282931579379625 -10.322665095458966 5.293776696605195 0.9997117450749132 2.1102901240105782 0.8743003171850827 0.19845726076953912 0.0006753336011949336 8.640839009941999e-05 0.1922028920445863 0.06405180549116414 4.7570192026710145e-11 10.322665095458966 1.110578378935665 MLGETCADCGTILLQDK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLGETCADCGTILLQDKQR 19 1 O60232;G3V1B8;H0YEB6;E9PN57;H0YEK1 O60232 SSSCA1 Sjoegren syndrome/scleroderma autoantigen 1 1 20503900.0 8700600.0 8673800.0 3129500.0 True False 11406570.85673026 7379702.850207584 2805689.3602837385 1.0 0.6469694479523013 0.24597132613508357 23.443361805395384 -7.403752684409921 0.35125248730749836 1.0534793661739756 1.0931444279480324e-10 0.9995629719651227 0.006439608063230583 0.11458149934256424 0.03293439869188546 0.016047991599533077 0.058739140867990564 3.946819957496798e-08 7.403752684409921 -1.0534793660646613 down MLGETCADCGTILLQDK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLGETCADCGTILLQDKQR 19 1 O60232;G3V1B8;H0YEB6;E9PN57;H0YEK1 O60232 SSSCA1 Sjoegren syndrome/scleroderma autoantigen 1 1 41021300.0 23276000.0 6716300.0 11029000.0 True False 35311393.703534104 5517723.790308583 8849113.31581757 1.0 0.15625902043499199 0.2506022104398535 25.073630428087206 -10.511309019875492 6.22814675840517 1.00072041785178 0.2034306171985007 0.9895890574513797 0.03851544603639222 0.0003855902215483371 3.0255261218714198e-05 0.03732214095420943 0.012430806755891451 3.0809949049570095e-11 10.511309019875492 -0.7972898006532791 MLHFLTAVVGSTCDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MLHFLTAVVGSTCDVK 16 0 Q8WWM7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7-3;H3BUF6;Q8WWM7-7;H3BSK9;H3BSQ5 Q8WWM7 ATXN2L Ataxin-2-like protein 0 14774300.0 8792600.0 1834100.0 4147600.0 False True 7311436.478224804 1824219.339259656 5014843.983664345 1.0 0.2495021798647386 0.6858903853708834 22.801723449703758 -10.79742327346411 7.7734366463041935 1.0141723591452756 0.4676962826229619 0.6648639947611283 0.17815473887647656 0.04220660666986509 0.0010999077582826526 0.16638299585669783 0.05749919472637706 1.594324524154256e-11 10.79742327346411 -0.5464760765223137 MLHFLTAVVGSTCDVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MLHFLTAVVGSTCDVK 16 0 Q8WWM7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7-3;H3BUF6;Q8WWM7-7;H3BSK9;H3BSQ5 Q8WWM7 ATXN2L Ataxin-2-like protein 0 21091700.0 4062200.0 9842800.0 7186700.0 False True 5258597.977933157 9295039.527483432 5878794.341769144 1.0 1.7675889213224776 1.117939490038702 22.326246775705048 -10.234935162643943 4.465096712601026 0.9998555557533839 1.4427642055666425 0.3824625497066978 0.265218270146921 0.00044860097880461387 7.686516926299045e-05 0.25689419583753725 0.08559882855200804 5.821901285022445e-11 10.234935162643943 0.4429086498132586 MLHVGDPSVK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLHVGDPSVKK 11 1 Q99959-2;Q99959 Q99959-2 PKP2 Plakophilin-2 1 3975020.0 906420.0 1451600.0 1617000.0 True False 1188325.3977837672 1235026.938292482 1449688.351359258 1.0 1.0393002965314158 1.219942243145635 20.180498511093024 -6.941698508548364 0.6435680101210649 0.9980168333166369 1.2711902550443037 0.9983780164053445 0.0038571066615148576 0.08700023405147139 0.051144600580635496 0.0038048139156509246 0.015434873497035895 1.1436720074968573e-07 6.941698508548364 0.2731734217276668 MLITILGTVKPNANR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLITILGTVKPNANR 15 1 P17931;G3V3R6 P17931 LGALS3 Galectin-3;Galectin 0 30476200.0 9020200.0 10318000.0 11138000.0 False True 13684302.86495182 8476672.285098046 8936569.418041188 1.0 0.619444948621275 0.6530525892502346 23.706018603927557 -9.953151978173516 5.924877658074147 1.0000002282222369 0.636248769421713 0.9936385389350607 0.013720261833694307 4.1368655650449945e-08 7.283595425354336e-09 0.013284594908670195 0.004428195465567116 1.1139046626001319e-10 9.953151978173516 -0.36375145880052384 MLITILGTVKPNANR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MLITILGTVKPNANR 15 1 P17931;G3V3R6 P17931 LGALS3 Galectin-3;Galectin 0 25930100.0 9020200.0 11549000.0 5360900.0 False True 11676826.7147242 10906287.99761309 4385271.20747912 1.0 0.9340112912577969 0.37555333436175753 23.477144926020006 -6.92906475126143 0.7544323106818298 1.00879378056188 0.26358945187765753 0.9963511595032093 0.016920327844546022 0.09312645132617789 0.08008145067103048 0.01533031235390163 0.050793212537218406 1.1774304111055678e-07 6.92906475126143 -0.7452043286842225 down MLIYDPAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLIYDPAKR 9 1 P06493;A0A024QZP7;P06493-2 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 2059830.0 782040.0 514110.0 763680.0 True False 1025262.013286134 437406.791985084 684661.7193358308 1.0 0.42662927750841273 0.6677919502170737 19.96756121755579 -10.316184762941653 5.762308314855143 1.000051944792008 0.547210613862747 0.8245657924391449 0.0984542488570153 6.570894344298617e-05 7.797828591343907e-06 0.09533880636053076 0.031775972182213855 4.8285333688546986e-11 10.316184762941653 -0.45284133092926093 MLLAHVDLIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MLLAHVDLIEK 11 0 P62875 P62875 POLR2L DNA-directed RNA polymerases I, II, and III subunit RPABC5 0 1297600.0 1297600.0 0.0 0.0 False True 1256408.3982703285 0.0 0.0 1.0 0.0 0.0 20.2608740609339 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 MLLDPMGGIVMTNDGNAILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MLLDPMGGIVMTNDGNAILR 20 0 P49368;B4DUR8;E9PRC8;Q5SZX6;Q5SZX9 P49368 CCT3 T-complex protein 1 subunit gamma 0 3380100.0 3380100.0 0.0 0.0 False True 3272800.5756731974 0.0 0.0 1.0 0.0 0.0 21.642094265427374 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 MLLEEEYYLSK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLLEEEYYLSKK 12 1 A0A590UJD8;Q5VVJ2;A0A590UJT8;A0A590UK32;A0A590UJW2 A0A590UJD8 MYSM1 Histone H2A deubiquitinase MYSM1 1 11542000.0 4543600.0 3601700.0 3396700.0 True False 5956703.600284994 3064340.3993166387 3045242.067447125 1.0 0.5144356014574953 0.5112294100551567 22.506082743104727 MLLEEEYYLSK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLLEEEYYLSKK 12 1 A0A590UJD8;Q5VVJ2;A0A590UJT8;A0A590UK32;A0A590UJW2 A0A590UJD8 MYSM1 Histone H2A deubiquitinase MYSM1 1 50447800.0 7863000.0 8618800.0 33966000.0 True False 11928745.86229975 7080707.801008234 27252605.212173317 1.0 0.5935835906594744 2.2846161303766155 23.50793903638546 -6.843248113533386 1.267265733087505 0.7838121942544244 2.3438988435222456 0.9299002650360625 0.19082177188050994 0.16502874804654832 0.5134198247128295 0.1180075847002073 0.2721440609497947 1.434669568835779e-07 6.843248113533386 1.5600866492678214 up MLLEEEYYLSK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLLEEEYYLSKK 12 1 A0A590UJD8;Q5VVJ2;A0A590UJT8;A0A590UK32;A0A590UJW2 A0A590UJD8 MYSM1 Histone H2A deubiquitinase MYSM1 1 13677200.0 4543600.0 5356400.0 3777200.0 True False 6223491.706173146 5119736.536753894 2885103.153875872 1.0 0.8226469606564388 0.4635827104925854 22.56929280462762 -6.959805804131166 0.43816977802824714 1.0130863776986816 0.2591865444059338 0.9997629080071145 0.003435864582690994 0.07977067504857499 0.021388902048555057 0.004723508336491715 0.0297612096987812 1.0969685987579179e-07 6.959805804131166 -0.7538998332927478 down MLLNLHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLLNLHK 7 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 9573700.0 2756800.0 3522900.0 3294000.0 False True 3614191.4968891726 2997297.052156644 2953168.4782791636 1.0 0.8293132930937651 0.8171034879643294 21.785241518330544 -13.999999999990608 0.3744205765399391 3.4446460635890586 0.81592438376598 0.9997983661385669 0.0011855159246293334 23.346731269358955 0.19903069115738936 45.89719066740088 0.0033660719635116155 1.0000000000216249e-14 13.999999999990608 -2.6287216798230784 MLLNLHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MLLNLHK 7 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 4429580.0 1686700.0 901180.0 1841700.0 False True 1633156.6317529024 1261025.8735916165 1359303.5201843057 1.0 0.7721401910104178 0.8323166888930523 20.639231731942477 -10.458276755521485 5.8864147602289405 1.0001280430873039 0.802228439951735 0.9350719364494765 0.024566952386688108 4.130854110999402e-05 3.8015953869775795e-06 0.023802177678092576 0.007928949788392755 3.481154067022622e-11 10.458276755521485 -0.19789960313556887 MLLNLHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLLNLHK 7 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 9974700.0 2756800.0 4076800.0 3141100.0 False True 3776063.4597187475 3896673.495825229 2399236.872985147 1.0 1.0319406803919193 0.6353804427756755 21.848451579853435 -6.887393266153027 1.037658500820263 1.0226580831269414 0.6029622809190249 0.9791774980449415 0.025957418188066402 0.12128451870136672 0.234395542243477 0.019122231136252537 0.04724682493403332 1.2960051694908397e-07 6.887393266153027 -0.41969580220791647 MLLNLHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MLLNLHK 7 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 3798790.0 1686700.0 1355000.0 757090.0 False True 1402565.7834794929 1347700.346053557 915394.0186113509 1.0 0.9608820933234052 0.6526567447984054 20.419637007376753 -6.930379745609238 0.7436690903764085 1.0046217970512668 0.5887635397379107 0.9966123229815461 0.009041489522669591 0.09244123262928536 0.07671794395212501 0.008255897274899799 0.027831095593373937 1.1738706775513253e-07 6.930379745609238 -0.415858257313356 MLLTVYCVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLLTVYCVR 9 0 Q5TDH0;Q5TDH0-3;Q5TDH0-2 Q5TDH0 DDI2 Protein DDI1 homolog 2 0 15612400.0 4177100.0 3422200.0 8013100.0 False True 6336966.086914948 2811481.672229358 6429307.2727334965 1.0 0.44366367653990135 1.0145718289402277 22.59536086410944 -10.845163263244455 12.065027857825235 1.0036700417172817 0.7291177527400652 0.23086982947409573 0.23307227722931578 0.023080704712594026 0.00029620606408709715 0.2263774142213613 0.0752237540143148 1.4283568989131235e-11 10.845163263244455 -0.2745522889772165 MLLTVYCVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLLTVYCVR 9 0 Q5TDH0;Q5TDH0-3;Q5TDH0-2 Q5TDH0 DDI2 Protein DDI1 homolog 2 0 5372000.0 0.0 2825500.0 2546500.0 False True 0.0 2700660.0673209806 1945069.1468137545 0.0 MLMAAGDKDGDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MLMAAGDKDGDGK 13 1 B8ZZ19;P20472;H0Y3U0;B1AH72 B8ZZ19 PVALB Parvalbumin alpha 0 3854540.0 1291800.0 481540.0 2081200.0 False True 1250792.51609557 673821.4331979257 1536071.285338314 1.0 0.5387155939350381 1.2280784107449412 20.25441106160502 -6.726385108165534 1.7364819087613228 0.7212885692302553 1.2273998159387927 0.5424016601263626 0.19397417524876182 0.3430544438802024 2.0248438427841555 0.08858537684602129 0.22071796521620718 1.8776510819379445e-07 6.726385108165534 0.5061112467085374 MLNIHPSLLPSFK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MLNIHPSLLPSFK 13 0 P22102;A0A140TA71 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 97949100.0 26084400.0 35983400.0 35881300.0 False True 34196901.00168888 30614816.982194662 32168647.273733426 1.0 0.8952512094789726 0.9406889610302616 25.02736225505163 -10.05768478844805 4.200517690005703 1.000008467600634 0.9179700852309355 0.8129301893218736 0.018549884472329737 5236459.963141458 4179378.761753792 375.5169967667624 0.006350118916099081 8.756190702156638e-11 10.05768478844805 -0.08203838236969851 MLNIHPSLLPSFK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MLNIHPSLLPSFK 13 0 P22102;A0A140TA71 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 87570600.0 37049400.0 13684600.0 36836600.0 False True 35873287.07681626 19148932.144246254 27187989.385687757 1.0 0.5337936304315304 0.7578895496102578 25.096406610012927 -10.08002055459594 5.0576887900155985 1.0000078745865688 0.6458415900196379 0.7690620018134753 0.09148677590900896 8.123660202165669e-06 1.4777506013491528e-06 0.0885836585279543 0.0295272299571911 8.317244057310808e-11 10.08002055459594 -0.3541662845669309 MLNIHPSLLPSFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLNIHPSLLPSFK 13 0 P22102;A0A140TA71 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 29325300.0 5286500.0 14551000.0 9487800.0 False True 8020006.994918932 11954260.362518102 7612532.171349532 1.0 1.4905548548887442 0.9491927097036754 22.935172064299937 -6.668044444676958 1.9438249969960988 1.3136275895866725 0.9513729903477283 0.27068453578596163 0.20846815106272826 0.46558048058772744 3.389477308096665 0.08638774814557935 0.23143702507510933 2.1476106814525946e-07 6.668044444676958 -0.3622545992389442 MLNIHPSLLPSFK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MLNIHPSLLPSFK 13 0 P22102;A0A140TA71 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 106649800.0 26084400.0 39104100.0 41461300.0 False True 35728507.58440499 37376351.5620338 31668994.86227729 1.0 1.0461212653155452 0.8863788891115166 25.090572316574523 -6.82949532562052 1.330302237769126 1.0246522940337843 0.8821286727561861 0.9048351915071069 0.02070793235281858 0.18143573611847513 0.6281641628043694 0.012223159809894192 0.028127496608493157 1.4808281935673462e-07 6.82949532562052 -0.1425236212775982 MLNIHPSLLPSFK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MLNIHPSLLPSFK 13 0 P22102;A0A140TA71 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 66410700.0 37049400.0 13665600.0 15695700.0 False True 30808217.666713182 13591980.700390773 18977598.301282775 1.0 0.44118036451931014 0.6159914379528411 24.876811885447204 -10.418424943914388 5.180588240503263 1.000457616495057 0.5285859012360609 0.9065097168471903 0.07136632188344884 0.0003775583544514175 4.238479239296505e-05 0.06916513855918044 0.023033381344548076 3.815707327892881e-11 10.418424943914388 -0.47187171525899607 MLNIHPSLLPSFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MLNIHPSLLPSFK 13 0 P22102;A0A140TA71 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 31686200.0 5286500.0 16736000.0 9663700.0 False True 6843478.462494118 15804626.887873642 7905005.757935409 1.0 2.3094435051547775 1.1551151656659726 22.706298386392387 -6.615784426579851 2.131958331477639 1.8714223732959647 1.1593968030683857 0.06876386511433819 0.5637169233904962 0.59695874107459 5.14970202516654 0.21769370067938554 0.6254589655926317 2.422231086105288e-07 6.615784426579851 -0.7120255702275791 MLPSTSRRLNHYVLYKAVQGFFTSNNATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MLPSTSRRLNHYVLYKAVQGFFTSNNATR 29 3 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 15466500.0 4699800.0 6077300.0 4689400.0 False True 4550607.421540453 8503997.582700836 3461105.461015514 1.0 1.868760979566569 0.7605809819217222 22.117627700471783 -6.6975998730685715 1.8390406140180653 1.5407435955102478 0.7639897957403383 0.40620398484873876 0.3668819174243993 0.40062763334477497 2.6324169776690103 0.1592411472886399 0.41080300684510185 2.0063196511783642e-07 6.6975998730685715 -0.7767537997699094 MLQK(ub)VVLPSYEEALSLPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLQKVVLPSYEEALSLPSK 19 1 Q13571 Q13571 LAPTM5 Lysosomal-associated transmembrane protein 5 1 35719100.0 4214100.0 15192000.0 16313000.0 True False 5524725.909402448 12925412.817952173 14625087.245345447 1.0 2.3395572974859453 2.6472059401997177 22.397471461166774 -10.28275021973041 0.3274389807756803 2.7548452874086493e-12 2.7242399675508375 0.9989944148671082 0.022676599001036996 1.7338240305003894 0.15283660601450358 1.6189356882689852 0.09867816884286622 5.2149455741934866e-11 10.28275021973041 2.724239967548083 MLQK(ub)VVLPSYEEALSLPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MLQKVVLPSYEEALSLPSK 19 1 Q13571 Q13571 LAPTM5 Lysosomal-associated transmembrane protein 5 1 39918800.0 9172800.0 10461000.0 20285000.0 True False 8881614.484936867 14638131.85339432 14971749.963044249 1.0 1.648138621443258 1.6857013990458822 23.08239052041524 -11.34533298564767 0.476319435491625 5.246634969909209e-07 1.6848505347482663 0.9998029441053773 0.004418530497402694 3.6654800148783764 0.23400980537317034 3.8457994186615494 0.00800379980755934 4.515096266486474e-12 11.34533298564767 1.6848500100847692 MLQK(ub)VVLPSYEEALSLPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLQKVVLPSYEEALSLPSK 19 1 Q13571 Q13571 LAPTM5 Lysosomal-associated transmembrane protein 5 1 103430000.0 15251000.0 65536000.0 22643000.0 True False 23136881.997447968 53840588.764894955 18167601.125220537 1.0 2.327046002604571 0.7852225346191614 24.463691119412758 -6.678965769395347 1.9058425406493271 1.8404234150368648 0.7911750251651152 0.3193087423915727 0.5625620497594699 0.4408039166394621 3.0947539222747817 0.23694757452812945 0.6256983013547499 2.0942775179541715e-07 6.678965769395347 -1.0492483898717495 MLQK(ub)VVLPSYEEALSLPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLQKVVLPSYEEALSLPSK 19 1 Q13571 Q13571 LAPTM5 Lysosomal-associated transmembrane protein 5 1 31288300.0 4214100.0 9969200.0 17105000.0 True False 5772166.651770451 9528727.780264137 13065151.288532985 1.0 1.6508060759717438 2.263474372231719 22.460681522689665 -6.971855295063374 0.20918569443405444 0.6758813393552139 3.2554867315595946 0.9999934640247959 0.001318887609892712 0.07570521668905751 0.006832563385153316 0.018465768888614176 0.06360743815468747 1.066951565396359e-07 6.971855295063374 2.579605392204381 MLQK(ub)VVLPSYEEALSLPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MLQKVVLPSYEEALSLPSK 19 1 Q13571 Q13571 LAPTM5 Lysosomal-associated transmembrane protein 5 1 33093800.0 9172800.0 11955000.0 11966000.0 True False 7627589.623940644 11890596.042118305 14468035.275467135 1.0 1.5588929961304425 1.896803051655591 22.862795795849518 -9.221575985055859 0.12269936988010607 1.566706397023403e-12 2.6547589644854375 0.9999083368830837 0.0035405381236634837 0.6787470475031689 0.044003699044395 0.5740549436093123 0.33980952858625524 6.003769565304879e-10 9.221575985055859 2.6547589644838707 MLQK(ub)VVLPSYEEALSLPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MLQKVVLPSYEEALSLPSK 19 1 Q13571 Q13571 LAPTM5 Lysosomal-associated transmembrane protein 5 1 80711000.0 15251000.0 19220000.0 46240000.0 True False 19742720.14215414 18150390.104262155 37824794.4624661 1.0 0.919345965174673 1.9158856626703424 24.234817441505207 -6.887290540163301 1.0382344720706176 0.9429256798274533 1.997195292341429 0.9791082701098551 0.06532674631169035 0.12137082066653251 0.23488777264306554 0.048103046944122374 0.11881428201487299 1.2963117567625967e-07 6.887290540163301 1.0542696125139757 MLQPCGPPADK(ub)PEEN ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLQPCGPPADKPEEN 15 1 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 1 9008600.0 3934800.0 3762400.0 1311400.0 True False 5158560.904657401 3201064.5857203314 1175708.9078370633 1.0 0.6205344174244902 0.22791412751869922 22.298537219219813 -7.542457507213869 0.3465360650171919 1.062117459160291 1.1258858715035829e-20 0.9993606909709746 0.007970146360291497 0.12294050540830789 0.04123453462322593 0.02245788363766567 0.06820774690477628 2.86775795263004e-08 7.542457507213869 -1.062117459160291 down MLQPCGPPADK(ub)PEEN ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLQPCGPPADKPEEN 15 1 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 1 24609200.0 13595000.0 9089300.0 1924900.0 True False 20624608.927631322 7467243.39997496 1544442.6712863578 1.0 0.36205502980329973 0.07488348878301532 24.297863428248007 -8.937602499252225 0.3516010091248909 1.1874172812118675 7.256721156678191e-18 0.9978962342599057 0.017733075006929763 0.4294996993499325 0.12509178777562638 0.19202119619048102 0.08021343418190488 1.1545094729994091e-09 8.937602499252225 -1.1874172812118675 MLQPCGPPADK(ub)PEEN ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLQPCGPPADKPEEN 15 1 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 1 7399200.0 3934800.0 2384400.0 1080000.0 True False 5389601.893971755 2279049.323843619 824926.2432981948 1.0 0.42286042061710066 0.15305884544475742 22.361747280742705 -9.220611790716887 0.261731096785376 1.3414156009706106 1.6386522346189022e-14 0.9990034221883357 0.011152220646006463 0.6433142193876029 0.09640714281578039 0.3030029598814901 0.10722086936568055 6.017113578640292e-10 9.220611790716887 -1.3414156009705942 MLQPSSSPLWGK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MLQPSSSPLWGKLR 14 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 11579800.0 1927500.0 2014400.0 7637900.0 True False 1866312.5675601573 2818760.4249572265 5637304.857911555 1.0 1.5103367324168055 3.020557732878175 20.831759196406388 -6.951758190973526 0.5392028812780206 0.9776482950257626 3.6228922289840284 0.999332094130345 0.02217134724535055 0.082787464280688 0.03310018535050437 0.024412740231124015 0.1250517532701235 1.1174852745959543e-07 6.951758190973526 2.645243933958266 MLQYCLQGLFHPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLQYCLQGLFHPAR 14 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 17589700.0 5567600.0 9563900.0 2458200.0 False True 7299177.516715103 8137003.399790208 2203849.0447194404 1.0 1.114783601461464 0.30193114767693074 22.79930247723362 -6.871137051606729 1.1281195358554221 1.0653804159323392 0.2532980461750915 0.9658020661084966 0.06642522509163273 0.13576636840744985 0.3222455965380176 0.04566587495707918 0.10832989296026536 1.345435703892024e-07 6.871137051606729 -0.8120823697572477 down MLQYCLQGLFHPAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLQYCLQGLFHPAR 14 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 59581000.0 10401000.0 15281000.0 33899000.0 False True 15779077.414953524 12553986.159002058 27198847.791540474 1.0 0.7956096436351145 1.7237286487842853 23.911509519259873 -6.848960868562667 1.2400023568888563 0.8910138913509582 1.760112613185037 0.9387908051083282 0.09851299090972132 0.15860507725797254 0.46980118928055625 0.06218064563020238 0.14380551297663074 1.4159213536286765e-07 6.848960868562667 0.8690987218340789 MLQYCLQGLFHPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLQYCLQGLFHPAR 14 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 30403600.0 5567600.0 13174000.0 11662000.0 False True 7626092.178732638 12591929.119407753 8907675.786429208 1.0 1.651164033202176 1.1680524674577895 22.862512538756512 -10.143678164398478 5.742417231804322 0.999995045435716 1.4096082503300058 0.48939890882466064 0.19722947081854791 1.2510618299745872e-05 1.86577085947142e-06 0.19096892380397304 0.06365553798844954 7.183264126414334e-11 10.143678164398478 0.40961320489428976 MLQYCLQGLFHPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MLQYCLQGLFHPAR 14 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 55018000.0 10401000.0 22587000.0 22030000.0 False True 13464299.534361359 21330013.59443127 18020766.046888568 1.0 1.5841903650461977 1.3384109586168185 23.682635841352322 -10.073559955782425 4.573673005848842 0.999976457465143 1.4613006616555995 0.8244674684116995 0.10033902258455178 69661790.08198239 1.0556570093499 19598.451684265212 0.034348716280329705 8.441896906991549e-11 10.073559955782425 0.4613242041904565 MLSELPALGISGIRPTYILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MLSELPALGISGIRPTYILR 20 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 0 4620500.0 2375200.0 0.0 2245300.0 False True 1975084.0392010955 0.0 2714781.8489057627 1.0 0.0 1.3745146004034687 20.91348261013756 -6.711632533398251 1.7895361825202076 0.3862337739695585 1.371417900611346 0.4727367380231746 0.4212905100039035 0.37182834135496123 2.322207360304525 0.1872792836679715 0.47481108543831835 1.942528800965558e-07 6.711632533398251 0.9851841266417876 MLSVHVVGYGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLSVHVVGYGK 11 0 O43847-2;G3V1R5;O43847;H0Y5G9 O43847-2 NRD1 Nardilysin 0 18812400.0 5655200.0 8089500.0 5067700.0 False True 7414021.965034706 6882578.132624027 4543343.016810955 1.0 0.9283190911873445 0.6128040944898505 22.82182495866518 -6.942683671635251 0.6341114938311777 1.0034440212428386 0.5205545562185215 0.998494633043284 0.0065258373328080325 0.0865635477359564 0.049193670714722755 0.00648987889740504 0.026851205401180113 1.1410806172338525e-07 6.942683671635251 -0.48288946502431707 MLSVHVVGYGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MLSVHVVGYGK 11 0 O43847-2;G3V1R5;O43847;H0Y5G9 O43847-2 NRD1 Nardilysin 0 14188900.0 3949600.0 2520700.0 7718600.0 False True 3824222.1099017328 3527228.6552768443 5696867.106963444 1.0 0.9223388584423722 1.4896799775862992 21.866734886457724 -6.872317676614664 1.1217016408820744 0.9553929663971639 1.5244121789352703 0.9669450697101274 0.04566189110016723 0.13465513726566627 0.3152349083330953 0.03154464558249878 0.0750022433820478 1.3417831180069986e-07 6.872317676614664 0.5690192125381064 MLSVHVVGYGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLSVHVVGYGK 11 0 O43847-2;G3V1R5;O43847;H0Y5G9 O43847-2 NRD1 Nardilysin 0 61252000.0 11930000.0 27403000.0 21919000.0 False True 18098682.1998265 22512720.549383767 17586700.04256102 1.0 1.2438872786881456 0.9717116333878503 24.109381319918473 -6.6705711711232585 1.9362210295701685 1.155602722644409 0.9728296477669993 0.2812660971840796 0.10358553911727433 0.4597682027525425 3.323841695796829 0.04307013212238628 0.11495040437624227 2.1351521538340602e-07 6.6705711711232585 -0.18277307487740968 MLSVHVVGYGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLSVHVVGYGK 11 0 O43847-2;G3V1R5;O43847;H0Y5G9 O43847-2 NRD1 Nardilysin 0 21838000.0 5655200.0 5557800.0 10625000.0 False True 7746080.2660336215 5312238.018813147 8115593.8287438145 1.0 0.6857969239109469 1.0477032963795252 22.88503502018807 -6.677137744715472 1.911872748260367 0.8006925090496926 1.0463023212041993 0.31112574640881563 0.13325075792725016 0.4449305154398174 3.141767897518954 0.055974099380896 0.14818145244155329 2.1031112924177653e-07 6.677137744715472 0.24560981215450672 MLSVHVVGYGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MLSVHVVGYGK 11 0 O43847-2;G3V1R5;O43847;H0Y5G9 O43847-2 NRD1 Nardilysin 0 9716200.0 3949600.0 2456400.0 3310200.0 False True 3284267.3969470537 2443166.885642773 4002347.5153644737 1.0 0.743900112370223 1.2186424038082049 21.647140161892 -6.760200578359836 1.6118456164758441 0.8512791811861555 1.2203862133781773 0.6917391000561097 0.10771883641789787 0.2825791597902532 1.4470144218704104 0.052729256808674616 0.1266850183163801 1.7369984129355566e-07 6.760200578359836 0.3691070321920218 MLSVHVVGYGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MLSVHVVGYGK 11 0 O43847-2;G3V1R5;O43847;H0Y5G9 O43847-2 NRD1 Nardilysin 0 63083000.0 11930000.0 29517000.0 21636000.0 False True 15443620.175457256 27874353.00247167 17698470.004107192 1.0 1.8049105511393713 1.1460052632111029 23.880507642010922 -10.116281436223437 4.422608917779514 0.9999494510690853 1.4754579069980565 0.4097688965121047 0.2689969575004903 187546971.47384062 13.398400938817728 112141.93068411735 0.09208481343284937 7.651006374083712e-11 10.116281436223437 0.4755084559289712 MLTFLMLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLTFLMLVR 9 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 14064000.0 0.0 0.0 14064000.0 False True 0.0 0.0 11284244.235529823 0.0 MLTFLMLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MLTFLMLVR 9 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 9547300.0 0.0 0.0 9547300.0 False True 0.0 0.0 7809789.363570553 0.0 MLTGPVYSQSTALTHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLTGPVYSQSTALTHK 16 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 3856700.0 1354200.0 2502500.0 0.0 False True 1854884.3358789638 2391931.2753391475 0.0 1.0 1.2895312279434914 0.0 20.82289779754148 -6.8860300935026135 1.3272487822760908 1.150928959740455 8.471644811667956e-20 0.9357829785109899 0.1399944921374783 0.1443110166341051 0.5108583955514463 0.0857394915140065 0.1735293764528074 1.3000794886983865e-07 6.8860300935026135 -1.150928959740455 down MLVELSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLVELSK 7 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 12986300.0 3910900.0 4862300.0 4213100.0 False True 5127227.773209478 4136863.7930969517 3777168.826908904 1.0 0.8068422110507116 0.7366883224196064 22.28974755911723 -13.999999999999998 0.14089194497360333 1.923434667686561 0.6507951159806462 0.9995993993646916 0.0022284156142958573 11.935021295740597 0.11766689383567454 3.028551219109461 0.0768344082049351 1.0000000000000041e-14 13.999999999999998 -1.2726395517059148 MLVELSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLVELSK 7 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 12894100.0 3910900.0 5139200.0 3844000.0 False True 5356865.418098547 4912133.15093824 2936126.3696650607 1.0 0.9169790105874701 0.5481053079558712 22.352957620640122 -6.942469263499204 0.6361761262264158 1.0040294970670685 0.4409629818534017 0.9984697786393543 0.007682919598574747 0.08665796199523107 0.04961362759145888 0.0076269008923390775 0.031419115752420186 1.141644099804024e-07 6.942469263499204 -0.5630665152136667 MLVIEQCK(ub)NSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MLVIEQCKNSR 11 1 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 1 9384000.0 5661900.0 3722100.0 0.0 True False 8589516.240335098 3057862.1740999627 0.0 1.0 0.35599934717402293 0.0 23.034145450708582 -8.470065663070697 0.5155713744159304 1.0480207146991318 3.167934823096746e-19 0.9932634513095453 0.03396763724182286 0.20931272110553012 0.18304704006473846 0.07600953804140827 0.06742527466907071 3.3879292853493034e-09 8.470065663070697 -1.0480207146991318 MLVSGAGDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLVSGAGDIK 10 0 P40227;P40227-2;Q92526;Q92526-2;Q92526-3 P40227;P40227-2;Q92526 CCT6A;CCT6B T-complex protein 1 subunit zeta;T-complex protein 1 subunit zeta-2 0 21667400.0 6975200.0 6459300.0 8232900.0 False True 9144554.747932876 5495597.618154202 7381038.483553284 1.0 0.6009694041578657 0.8071512158885337 23.124481495603536 -10.145759111764542 4.841157865444876 1.0000191188630982 0.7040603100249353 0.7331134323026012 0.08417337218153152 1.9680802483755422e-05 3.4726599089678017e-06 0.0815064779920298 0.027166839051800947 7.148927425809617e-11 10.145759111764542 -0.29595880883816295 MLVSGAGDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MLVSGAGDIK 10 0 P40227;P40227-2;Q92526;Q92526-2;Q92526-3 P40227;P40227-2;Q92526 CCT6A;CCT6B T-complex protein 1 subunit zeta;T-complex protein 1 subunit zeta-2 0 15397600.0 6559400.0 1595000.0 7243200.0 False True 6351175.437434024 2231891.81781512 5345988.628657744 1.0 0.3514139767987325 0.841732161443427 22.59859219125988 -9.948152352432606 6.657737396003856 1.0000000400718585 0.5965730691211922 0.4744133109340709 0.2001715606645589 1.1902814021049943e-07 1.8653056772042447e-08 0.19381530042597375 0.06460509340317941 1.1268020996533679e-10 9.948152352432606 -0.40342697095066626 MLVSGAGDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLVSGAGDIK 10 0 P40227;P40227-2;Q92526;Q92526-2;Q92526-3 P40227;P40227-2;Q92526 CCT6A;CCT6B T-complex protein 1 subunit zeta;T-complex protein 1 subunit zeta-2 0 21623700.0 6975200.0 7333200.0 7315300.0 False True 9554119.937692326 7009194.976350467 5587576.803332673 1.0 0.7336306244909301 0.5848342746137097 23.187691557126428 -13.999999999996179 0.06871290210027003 2.558298212809685 0.03021355898979408 0.9999287145560297 0.0014500122113105668 12.373712515829832 0.07030958381696306 3.1158724522415246 0.5119165087407381 1.000000000008798e-14 13.999999999996179 -2.528084653819891 MLVSGAGDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MLVSGAGDIK 10 0 P40227;P40227-2;Q92526;Q92526-2;Q92526-3 P40227;P40227-2;Q92526 CCT6A;CCT6B T-complex protein 1 subunit zeta;T-complex protein 1 subunit zeta-2 0 15031300.0 3935700.0 6744900.0 4350700.0 False True 5094841.234245356 6369540.385756391 3558917.241951799 1.0 1.2501940870979549 0.6985334926690691 22.28060575906449 -6.783390122459306 1.5224671092900601 1.1410447048046888 0.6936755474491887 0.7792432069222092 0.10596873050394713 0.24535489763729978 1.1234542943725867 0.054806999386401954 0.12897057730306655 1.646682528241197e-07 6.783390122459306 -0.4473691573555001 MLVTFDEELRPLPVSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MLVTFDEELRPLPVSVR 17 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 11791800.0 4758500.0 3538500.0 3494800.0 False True 4607444.022171207 4951441.5030337265 2579407.0382473306 1.0 1.074661239335126 0.5598346992030983 22.135535207361045 -6.870077916497557 1.1336200093133137 1.0422498624389918 0.529631007296898 0.9647641366789406 0.0426384571117837 0.13678351163651656 0.3284773035726661 0.029187882915423864 0.06911617632845117 1.3487208877251577e-07 6.870077916497557 -0.5126188551420937 MLVTFDEELRPLPVSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MLVTFDEELRPLPVSVR 17 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 7883200.0 4758500.0 0.0 3124700.0 False True 3956903.5872930316 0.0 3778060.3230195725 1.0 0.0 0.9548022183689828 21.91594048279532 -11.850791836156725 13.543683851475947 0.8541775620919697 0.5296609982659609 0.0 0.4769712104051414 0.0 0.0 0.0 0.13542943808814298 1.4099644535422046e-12 11.850791836156725 -0.3245165638260088 MLWFQGAIPAAIATAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLWFQGAIPAAIATAK 16 0 Q92575;F8WB86;Q6PJ80;C9JLR4 Q92575 UBXN4 UBX domain-containing protein 4 0 3283140.0 840620.0 1486900.0 955620.0 False True 1102060.960575661 1265060.3158908037 856741.60935432 1.0 1.1479041188701578 0.7773994724455183 20.071772598213045 -6.7983602237697935 1.4624940287744388 1.0817746961003427 0.7724830933584902 0.8273675147791004 0.06327054257148886 0.22309823199724127 0.9422208275304083 0.03403627691311639 0.07923988124239992 1.5908886236313436e-07 6.7983602237697935 -0.3092916027418525 MLWFQGAIPAAIATAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLWFQGAIPAAIATAK 16 0 Q92575;F8WB86;Q6PJ80;C9JLR4 Q92575 UBXN4 UBX domain-containing protein 4 0 4546620.0 840620.0 1186200.0 2519800.0 False True 1151419.9309013274 1133789.7617611587 1924675.1369099948 1.0 0.9846883238104382 1.671566632864663 20.134982659735936 -6.901805788609211 0.9498161158187965 0.9728391393246795 1.7463603216035661 0.987442285423058 0.035887551953888555 0.11008773409832058 0.17003375077969643 0.028239695794520084 0.07416051729088281 1.2537016902731964e-07 6.901805788609211 0.7735211822788867 MLYLIGLGLGDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MLYLIGLGLGDAK 13 0 Q9H2P9-3;Q9H2P9-2;Q9H2P9-6;Q9H2P9-4;Q9H2P9;Q9H2P9-5 Q9H2P9-3 DPH5 Diphthine synthase 0 2460250.0 678780.0 1079800.0 701670.0 False True 889887.1533148711 918698.0490274346 629067.9192939092 1.0 1.0323758980059905 0.7069075184989488 19.763262873802212 -6.882433482309175 1.0661792652785962 1.0207894949195402 0.6827420221182007 0.9755940648230588 0.022870268274764644 0.12549431340855977 0.2594695571965762 0.016486637753749655 0.040125661052108554 1.3108908064919217e-07 6.882433482309175 -0.3380474728013395 MLYLIGLGLGDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MLYLIGLGLGDAK 13 0 Q9H2P9-3;Q9H2P9-2;Q9H2P9-6;Q9H2P9-4;Q9H2P9;Q9H2P9-5 Q9H2P9-3 DPH5 Diphthine synthase 0 5758240.0 2277000.0 3155300.0 325940.0 False True 2204717.881366785 4415227.744672124 240566.53600959596 1.0 2.002627085300802 0.1091144304868884 21.072162627740614 -6.762852138332744 1.6018616634323402 1.5803082127863342 0.10123217414729593 0.7024774853294977 0.4218950512645111 0.27813970540054234 1.4072515560197316 0.20775172343186687 0.4978388441765799 1.7264255778218143e-07 6.762852138332744 -1.4790760386390382 MLYLIGLGLGDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MLYLIGLGLGDAK 13 0 Q9H2P9-3;Q9H2P9-2;Q9H2P9-6;Q9H2P9-4;Q9H2P9;Q9H2P9-5 Q9H2P9-3 DPH5 Diphthine synthase 0 11606480.0 678780.0 5973300.0 4954400.0 False True 929743.3093397764 5709379.854938399 3784272.759070906 1.0 6.140813058383511 4.070233924843374 19.826472935325103 -9.922245332313306 8.7642806485233 0.9999999985291536 5.105523491613443 0.8397934309645707 0.8453103915379075 2.4583402100580714e-08 0.0 0.8184682611025323 0.2728227557335322 1.1960646852535633e-10 9.922245332313306 4.10552349308429 MLYVWALCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MLYVWALCR 9 0 O43615;M0QXM9 O43615 TIMM44 Mitochondrial import inner membrane translocase subunit TIM44 0 16661100.0 4005100.0 4615400.0 8040600.0 False True 5184680.902323883 4358548.932737326 6577293.303523032 1.0 0.8406590520901167 1.2686013715086981 22.305823768622783 -6.805909357974068 1.4319632204543213 0.9127315703437361 1.275386042902281 0.8487894085942006 0.06867023207669036 0.2124396861300177 0.8593278662676557 0.037718300830336546 0.08741076625844185 1.5634739227616917e-07 6.805909357974068 0.3626544725585449 MMAVAALVVNFSQPVAGRPSLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MMAVAALVVNFSQPVAGRPSLLR 23 1 E9PCB6;Q9BYT8;H0YAK4;H0YAF7 E9PCB6 NLN Neurolysin, mitochondrial 0 19052000.0 4626600.0 6330100.0 8095300.0 False True 7018890.449766761 5200444.197702964 6495260.406703962 1.0 0.7409211234912173 0.9253970343588709 22.7428115558176 -10.09559183556112 6.418101579497285 1.00000026164896 0.8331590792255745 0.5216678870533384 0.07531197524348594 2.8194070144448726e-07 3.9701545502632214e-08 0.07292062110737167 0.024306835490666825 8.02431861336325e-11 10.09559183556112 -0.16684118242338553 MMEVAAADVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MMEVAAADVK 10 0 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;A0A087WYZ1;J3KSV5;J3QRD0;J3QKQ0;J3QLU1;J3QR27;J3QL02;J3QQN6;A0A087WVS2;J3KRD5;J3KSS4 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 9901600.0 1827000.0 5001900.0 3072700.0 False True 2395214.692693168 4255636.017253497 2754766.4794196654 1.0 1.776724245319521 1.1501125505881977 21.191723545620448 -10.084229627933217 4.394265023732779 0.9999572209417438 1.463418397981558 0.4217212694970137 0.25581315329075976 38373091.782295644 44030473.26705411 12950.392004944613 0.0875716472942637 8.237024771723128e-11 10.084229627933217 0.46346117703981426 MMEVAAADVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MMEVAAADVK 10 0 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;A0A087WYZ1;J3KSV5;J3QRD0;J3QKQ0;J3QLU1;J3QR27;J3QL02;J3QQN6;A0A087WVS2;J3KRD5;J3KSS4 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 11012600.0 1827000.0 4013400.0 5172200.0 False True 2502491.2728185426 3836074.7174609913 3950632.884802706 1.0 1.5329023358153178 1.5786799849068522 21.25493360714334 -11.582190741406432 0.40457435629415406 4.3425555572506957e-10 1.5815733682266926 0.9996862825657238 0.004652393173273749 4.210850258265453 0.20337119557265382 3.6701645253153994 0.011555057166177184 2.617033359123221e-12 11.582190741406432 1.581573367792437 MMLTHLVVRPGLGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MMLTHLVVRPGLGSK 15 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y5M9;K7EMY3;Q8TDI0;Q12873-3;Q12873;Q12873-2;A0A5F9ZHX5 A0A2R8YFD8 CHD4;CHD5;CHD3 Chromodomain-helicase-DNA-binding protein 4;Chromodomain-helicase-DNA-binding protein 5;Chromodomain-helicase-DNA-binding protein 3 0 31084400.0 9876800.0 9059600.0 12148000.0 False True 12948580.447067268 7707942.994044217 10891041.491844343 1.0 0.5952732058586386 0.8410992646156098 23.62629060812859 -10.332038109335695 5.823838276630098 1.0000362961177822 0.7181862352371234 0.6366668971474586 0.10035806823900566 4.730195279109019e-05 5.425448106051769e-06 0.09718377297056441 0.03239042724560095 4.655452401411793e-11 10.332038109335695 -0.2818500608806588 MMLTHLVVRPGLGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MMLTHLVVRPGLGSK 15 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y5M9;K7EMY3;Q8TDI0;Q12873-3;Q12873;Q12873-2;A0A5F9ZHX5 A0A2R8YFD8 CHD4;CHD5;CHD3 Chromodomain-helicase-DNA-binding protein 4;Chromodomain-helicase-DNA-binding protein 5;Chromodomain-helicase-DNA-binding protein 3 0 20887900.0 5532600.0 3639300.0 11716000.0 False True 5356970.641392129 5092491.468698779 8647228.12753397 1.0 0.9506289673029422 1.6142011421004905 22.35298595878586 -6.888976989247622 1.0283787695168178 0.9634662834432339 1.6701512860085288 0.980236697797186 0.042434363620486984 0.11997863365913648 0.22670931005063652 0.03148096027710629 0.07820171051379067 1.2912876896661306e-07 6.888976989247622 0.7066850025652949 MMLTHLVVRPGLGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MMLTHLVVRPGLGSK 15 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y5M9;K7EMY3;Q8TDI0;Q12873-3;Q12873;Q12873-2;A0A5F9ZHX5 A0A2R8YFD8 CHD4;CHD5;CHD3 Chromodomain-helicase-DNA-binding protein 4;Chromodomain-helicase-DNA-binding protein 5;Chromodomain-helicase-DNA-binding protein 3 0 28622000.0 5562000.0 12926000.0 10134000.0 False True 8437960.636666823 10619254.308701038 8131010.45811001 1.0 1.2585095813976057 0.963622705559567 23.008462926682572 -6.675126846828209 1.9188971881592893 1.1642747260148036 0.9647778194913255 0.3019681985617567 0.10968179306362759 0.4495215939683616 3.195696287029266 0.04593361770891401 0.12192199405629611 2.112871831364163e-07 6.675126846828209 -0.19949690652347818 MMLTHLVVRPGLGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MMLTHLVVRPGLGSK 15 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y5M9;K7EMY3;Q8TDI0;Q12873-3;Q12873;Q12873-2;A0A5F9ZHX5 A0A2R8YFD8 CHD4;CHD5;CHD3 Chromodomain-helicase-DNA-binding protein 4;Chromodomain-helicase-DNA-binding protein 5;Chromodomain-helicase-DNA-binding protein 3 0 34304800.0 9876800.0 10771000.0 13657000.0 False True 13528519.870483965 10295101.60506611 10431497.874743938 1.0 0.7609924591623353 0.7710745872135653 23.68950066965148 -9.955676849436838 5.489804533170017 1.0000004325373884 0.7660335231899021 0.9986092315107656 0.004116011542905469 2.179028060831751e-08 4.143103993205278e-09 0.003985318402577358 0.0013284370129517044 1.1074475088716821e-10 9.955676849436838 -0.2339669093474862 MMLTHLVVRPGLGSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MMLTHLVVRPGLGSK 15 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y5M9;K7EMY3;Q8TDI0;Q12873-3;Q12873;Q12873-2;A0A5F9ZHX5 A0A2R8YFD8 CHD4;CHD5;CHD3 Chromodomain-helicase-DNA-binding protein 4;Chromodomain-helicase-DNA-binding protein 5;Chromodomain-helicase-DNA-binding protein 3 0 13516600.0 5532600.0 3982100.0 4001900.0 False True 4600602.035737617 3960647.636915033 4838678.787305025 1.0 0.8608976838571564 1.0517490427813623 22.133391234220138 -6.711280034480006 1.790674606579694 0.9145948871751767 1.051317156723873 0.47116515306238926 0.05860534104687158 0.3725085675749067 2.329175966733366 0.026037196021865498 0.06604344300658845 1.9441061115049883e-07 6.711280034480006 0.13672226954869637 MMLTHLVVRPGLGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MMLTHLVVRPGLGSK 15 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y5M9;K7EMY3;Q8TDI0;Q12873-3;Q12873;Q12873-2;A0A5F9ZHX5 A0A2R8YFD8 CHD4;CHD5;CHD3 Chromodomain-helicase-DNA-binding protein 4;Chromodomain-helicase-DNA-binding protein 5;Chromodomain-helicase-DNA-binding protein 3 0 36176000.0 5562000.0 15097000.0 15517000.0 False True 7200118.643411016 14256838.67867042 12693065.21786518 1.0 1.980083854828859 1.762896675248661 22.77958924877502 -10.134954958970606 5.614210144232832 0.9999878757686467 1.8714902650388616 0.9554926333780139 0.08866629477465128 1.3457763090613224e-05 2.073619738231557e-06 0.08585196345971127 0.028616923585958434 7.329005389008286e-11 10.134954958970606 0.871502389270215 MMNGGHYTYSENR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MMNGGHYTYSENR 13 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 17405700.0 1971600.0 6743500.0 8690600.0 False True 2584786.693001559 5737396.085957118 7791380.078121702 1.0 2.219678746215852 3.0143222646639503 21.301613797776827 -8.34633479707485 0.18478675498029123 7.171635930287054e-16 4.107543171410686 0.999806811861227 0.01151443307392896 0.10544138314793815 0.043023033754127187 0.41336448676462595 0.3973819322841979 4.504693044281319e-09 8.34633479707485 4.107543171410685 MMNGGHYTYSENR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MMNGGHYTYSENR 13 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 19253060.0 5407500.0 3184960.0 10660600.0 False True 5235841.872415846 4456731.137346989 7868269.0488553 1.0 0.8511966644421651 1.5027705649989076 22.31999009645333 -6.84664814427995 1.2511231093630522 0.9207650239717572 1.5271865535484392 0.9352912928940058 0.07091602914628055 0.16118068403731475 0.4871910321767761 0.044388962736930646 0.10252469178173884 1.423481593165074e-07 6.84664814427995 0.606421529576682 MMNGGHYTYSENR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MMNGGHYTYSENR 13 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 20877810.0 2619210.0 8558400.0 9700200.0 False True 3587602.718488809 8180261.589155865 7409212.541889951 1.0 2.2801470037355758 2.0652265937101593 21.774588708243627 -10.177376850494136 4.792844913184786 0.9998661936588782 2.172686798727968 0.975427601240694 0.08774088999622084 30771571.982391648 11.534800812877902 45439.76821092191 0.03003604041392343 6.646961288945677e-11 10.177376850494136 1.1728206050690897 MMNGGHYTYSENR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MMNGGHYTYSENR 13 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 6959480.0 4248000.0 2022300.0 689180.0 False True 3532400.218308459 2011405.4685048806 833284.3515917128 1.0 0.5694160752453105 0.23589749181669542 21.75221737784242 -7.943613583621635 0.285526464626147 1.133095163380391 2.2354361478621812e-24 0.9993847598843382 0.007758238270130134 0.10571431846146931 0.05137901733487314 0.05579566919829719 0.08966048805804326 1.1386399476452732e-08 7.943613583621635 -1.133095163380391 down MMNGGHYTYSENR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MMNGGHYTYSENR 13 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 7171900.0 2876900.0 2338400.0 1956600.0 False True 3724203.762177114 2208265.9843811956 1600518.8764113567 1.0 0.5929498291173726 0.42976136071451615 21.828500578483073 -13.999999999993243 0.12601692890293892 2.9346473501782193 0.18923100969440235 0.9996640024909847 0.004395399935720736 11.944707085240898 0.10997973761380556 5.746124819264165 0.2136460405417779 1.0000000000155592e-14 13.999999999993243 -2.7454163404838168 MMQINLTGFLNGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MMQINLTGFLNGK 13 0 E9PCT1;A9Z1X7;Q8IYB3-2;Q8IYB3;M0R088;M0QXG5 E9PCT1 SRRM1 Serine/arginine repetitive matrix protein 1 0 20671440.0 9026600.0 6988250.0 4656590.0 False True 11833960.013718745 5945630.339985155 4174770.735965377 1.0 0.5024210266971131 0.352778844201408 23.49642958963543 -13.999999999999998 0.16835967863304643 3.4987125865838253 0.21844559064682828 0.9995169044334307 0.006080854435849365 12.075967319121446 0.12990004088223323 9.85321980427415 0.12384766774643942 1.0000000000000041e-14 13.999999999999998 -3.280266995936997 MMQINLTGFLNGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MMQINLTGFLNGK 13 0 E9PCT1;A9Z1X7;Q8IYB3-2;Q8IYB3;M0R088;M0QXG5 E9PCT1 SRRM1 Serine/arginine repetitive matrix protein 1 0 92296500.0 53698500.0 21824000.0 16774000.0 False True 51993870.510572776 30538437.01065649 12380386.190786518 1.0 0.5873468682129869 0.23811241727559038 25.631838220057126 -7.785788832615893 0.3007282278831355 1.106969994337488 2.688854617137887e-12 0.999407811105655 0.007577853629213194 0.11965472448876038 0.046710381082306386 0.04077227573652113 0.08202778967482711 1.637612585670137e-08 7.785788832615893 -1.106969994334799 down MMQINLTGFLNGK ddPTM_RPMI8226_Bortezomib_8h_R1 3 MMQINLTGFLNGK 13 0 E9PCT1;A9Z1X7;Q8IYB3-2;Q8IYB3;M0R088;M0QXG5 E9PCT1 SRRM1 Serine/arginine repetitive matrix protein 1 0 309055000.0 95852000.0 102483000.0 110720000.0 False True 145414491.71984658 84194107.94666621 88836143.46969996 1.0 0.5789939293593471 0.6109167141391271 27.115595811647605 -10.359294118371272 6.93025578272911 1.000014697607421 0.5949553217492372 0.995362984859922 0.013032422313190989 2.9596365033295542e-06 2.736188175611468e-07 0.012619045812666953 0.004206196214977556 4.372259012461549e-11 10.359294118371272 -0.40505937585818375 MMQINLTGFLNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MMQINLTGFLNGK 13 0 E9PCT1;A9Z1X7;Q8IYB3-2;Q8IYB3;M0R088;M0QXG5 E9PCT1 SRRM1 Serine/arginine repetitive matrix protein 1 0 30609090.0 9026600.0 9194290.0 12388200.0 False True 12363977.954692861 8788055.866348838 9462362.302987697 1.0 0.710778998357341 0.7653169827430961 23.55963965115832 -10.639231450660878 6.5767247100877055 1.001110570929795 0.7380479905502197 0.9685136908861726 0.022265038890829366 0.000363995354508732 1.9967084631355374e-05 0.021643309767925605 0.007186010402236886 2.294925276514146e-11 10.639231450660878 -0.2630625803795752 MMQINLTGFLNGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MMQINLTGFLNGK 13 0 E9PCT1;A9Z1X7;Q8IYB3-2;Q8IYB3;M0R088;M0QXG5 E9PCT1 SRRM1 Serine/arginine repetitive matrix protein 1 0 86628000.0 53698500.0 17484900.0 15444600.0 False True 44652681.9969013 17390705.373219073 18673994.452237997 1.0 0.3894660879367987 0.4182054384445236 25.412243495491403 -10.699502845423062 6.737453692907868 1.0056335252313235 0.40383576319069575 0.9982600885929838 0.01173279071382045 0.000994614687249258 4.436075166588635e-05 0.011380533014794237 0.0037867419199303027 1.997547680809557e-11 10.699502845423062 -0.6017977620406278 MMQINLTGFLNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MMQINLTGFLNGK 13 0 E9PCT1;A9Z1X7;Q8IYB3-2;Q8IYB3;M0R088;M0QXG5 E9PCT1 SRRM1 Serine/arginine repetitive matrix protein 1 0 238739700.0 84559000.0 80089600.0 74091100.0 False True 109463292.4070823 75632543.35558352 60607280.03888451 1.0 0.6909397816604507 0.5536767504990852 26.705871914397864 -13.999999999999998 0.10995759698938998 2.4913572954304435 0.30171911093132486 0.999743277341153 0.002990701011697141 12.01289146147329 0.10061690072206093 3.977670064764501 0.22379296983125394 1.0000000000000041e-14 13.999999999999998 -2.1896381844991186 MMTK(ub)MDPQDQAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MMTKMDPQDQAQR 13 1 Q92556;H7C0N5;H7C0S6;H7C3P3 Q92556 ELMO1 Engulfment and cell motility protein 1 1 15599130.0 966130.0 5038900.0 9594100.0 True False 1465689.8435639902 4139668.9258946073 7697821.929756592 1.0 2.824382623699251 5.2520128754105775 20.483148414615343 -6.967171566601053 0.31859215816854464 0.6619960234105836 7.492539093783797 0.9999511628746872 0.012171553026200418 0.07723160876611584 0.012301247208461857 0.03701034143492842 0.21380764281437808 1.07852057207e-07 6.967171566601053 6.830543070373213 MMTK(ub)MDPQDQAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MMTKMDPQDQAQR 13 1 Q92556;H7C0N5;H7C0S6;H7C3P3 Q92556 ELMO1 Engulfment and cell motility protein 1 1 11646330.0 966130.0 2765300.0 7914900.0 True False 1250674.33026945 2611408.624105937 6474469.41373212 1.0 2.0880004977341504 5.176782841890771 20.254274736707792 -6.952684186631037 0.5285556687382842 0.950774596782019 6.453881098014236 0.9993954387147757 0.04350018157704316 0.08242549490684851 0.031637814655309654 0.04863497839780257 0.2553789070193327 1.1151051289555963e-07 6.952684186631037 5.5031065012322165 MMVAGFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MMVAGFK 7 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 15295900.0 3399000.0 8160300.0 3736600.0 False True 4456121.9159628255 6942815.048600268 3349972.4759981525 1.0 1.558039743870012 0.7517685869405417 22.087357273534632 -6.720548239035735 1.7575117846288895 1.3393152647234818 0.7530039930284919 0.5149805173939254 0.23481046997979566 0.3542775949167726 2.1389685015449165 0.10607478739437246 0.2660988147411819 1.9030568447782262e-07 6.720548239035735 -0.58631127169499 MMVAGFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MMVAGFK 7 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 10855300.0 3399000.0 5031200.0 2425100.0 False True 4655702.1545212 4808904.948046486 1852341.3265022717 1.0 1.0329064850887226 0.39786508350914246 22.150567335057524 -6.894684242379209 0.9942755649885171 1.0303895657422515 0.33796069838036774 0.983730513966318 0.03723425215976329 0.1154241707923674 0.20031215544596728 0.02834402478085584 0.07196284911146515 1.2744293293042904e-07 6.894684242379209 -0.6924288673618837 down MMVGNNLK(ub)DTQLQQIVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MMVGNNLKDTQLQQIVDK 18 1 F6U1T9;D3YTA9;H7BYZ3;P63098 F6U1T9 PPP3R1 Calcineurin subunit B type 1 1 23662100.0 4741700.0 8272400.0 10648000.0 True False 6216414.618688123 7038190.16556264 9546247.102828316 1.0 1.1321944556922008 1.5356516076211952 22.567651300286116 -6.951063591679688 0.5470415236343525 0.9943199404278025 1.6923840615690582 0.9992821340861617 0.006104362788615719 0.08306143332688805 0.03421631158188962 0.006651005079911135 0.033451937466599344 1.1192739814910642e-07 6.951063591679688 0.6980641211412557 MMVGNNLK(ub)DTQLQQIVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MMVGNNLKDTQLQQIVDK 18 1 F6U1T9;D3YTA9;H7BYZ3;P63098 F6U1T9 PPP3R1 Calcineurin subunit B type 1 1 38530500.0 7799300.0 6433200.0 24298000.0 True False 7551715.490620982 9002010.308694812 17933624.875624835 1.0 1.1920483921666614 2.374774963105786 22.848372981799074 -6.935286091450031 0.7020518859556084 0.9850459518021805 2.6538582181412402 0.997478915547347 0.030522210913257956 0.08998444585854619 0.06490592405255112 0.028740538453387258 0.10408240411423007 1.1606837616235646e-07 6.935286091450031 1.6688122663390597 up MMVGNNLK(ub)DTQLQQIVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MMVGNNLKDTQLQQIVDK 18 1 F6U1T9;D3YTA9;H7BYZ3;P63098 F6U1T9 PPP3R1 Calcineurin subunit B type 1 1 131458400.0 8311400.0 69138000.0 54009000.0 True False 12609001.444730757 56799783.72234038 43334097.477014415 1.0 4.5047011828265555 3.436758863654785 23.587950691838238 -9.193345616173861 14.10422605073667 1.000018341855146 3.9707300232403364 0.9116403428804329 0.4359856262444951 0.0 9.836823068277202e-18 0.4221412610592951 0.1407137557831915 6.406994981651814e-10 9.193345616173861 2.9707116813851906 MMVGNNLK(ub)DTQLQQIVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MMVGNNLKDTQLQQIVDK 18 1 F6U1T9;D3YTA9;H7BYZ3;P63098 F6U1T9 PPP3R1 Calcineurin subunit B type 1 1 29432600.0 4741700.0 5584900.0 19106000.0 True False 6494834.629624352 5338140.651205436 14593556.30042159 1.0 0.8219055535081705 2.2469480953151924 22.630861361809007 -6.875574039908134 1.1041458817751295 0.894926931323274 2.3397608581290674 0.9699384508774388 0.10992065164896063 0.1316247677637805 0.29656972293050327 0.07696661810622159 0.1842096381428281 1.3317599802704875e-07 6.875574039908134 1.4448339268057935 up MMVGNNLK(ub)DTQLQQIVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MMVGNNLKDTQLQQIVDK 18 1 F6U1T9;D3YTA9;H7BYZ3;P63098 F6U1T9 PPP3R1 Calcineurin subunit B type 1 1 45985500.0 12544000.0 16837600.0 16603900.0 True False 10430891.793423109 16746892.506798057 20075698.72224045 1.0 1.605509177782605 1.9246387672143805 23.314359171153477 -9.95553063167687 0.14625954702358146 2.1957444012951728e-16 2.4243228915639765 0.999754228073738 0.00601169755431056 1.5173053067196614 0.06737844400148542 0.874525307818481 0.2889027996016498 1.1078204257812562e-10 9.95553063167687 2.4243228915639765 MMVGNNLK(ub)DTQLQQIVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MMVGNNLKDTQLQQIVDK 18 1 F6U1T9;D3YTA9;H7BYZ3;P63098 F6U1T9 PPP3R1 Calcineurin subunit B type 1 1 123160400.0 8311400.0 44832000.0 70017000.0 True False 10759271.142187376 42337059.78950469 57274624.43508843 1.0 3.9349375278312304 5.323281073428215 23.359077013930687 -8.86146816728077 0.3162548230927973 2.661412261858739e-20 5.8968796278851485 0.9984394617827691 0.07119443864649284 0.37118946908237327 0.10512083038921097 0.8972888068162383 0.44158361961096343 1.375725643891809e-09 8.86146816728077 5.8968796278851485 MNASPLFLHFVILHGTPNFDTGGVCRPFLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MNASPLFLHFVILHGTPNFDTGGVCRPFLK 30 1 Q68CZ2;Q68CZ2-2;E9PCX8;Q68CZ2-3;C9JHU5;Q68CZ2-4 Q68CZ2 TNS3 Tensin-3 0 181285500.0 42292000.0 58612000.0 80381500.0 False True 64160055.95935146 48152230.66235381 64494061.292536914 1.0 0.750501693652833 1.0052058142436326 25.935172064299937 -11.015476643318426 10.25398868171681 1.1760262551243585 0.8778537539482328 0.23467752901596206 0.10398252180529555 0.05697113225589702 8.598822543986115e-05 0.013707840076208915 0.033560214604046595 9.649912083579072e-12 11.015476643318426 -0.2981725011761257 MNESK(ub)AWEVDTCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MNESKAWEVDTCR 13 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 34553000.0 10202000.0 14302000.0 10049000.0 True False 13374920.796308532 12168197.348759351 9009225.87681459 1.0 0.9097771518854724 0.673590970295774 23.673027012389902 -6.954467465074511 0.5074349581830243 1.0044401534976397 0.5686113278670526 0.9995068346503119 0.0030562882895601028 0.08173989646451103 0.028910541378756843 0.003536035463504847 0.019489887853051304 1.1105357273733931e-07 6.954467465074511 -0.4358288256305871 MNESK(ub)AWEVDTCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MNESKAWEVDTCR 13 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 26098600.0 10202000.0 7293700.0 8602900.0 True False 13973955.098683504 6971440.216959502 6571072.202287076 1.0 0.49888812206189825 0.47023710580737027 23.736237073912793 -13.999999999999998 0.40746485476629174 9.86313278144272 0.4688452300604641 0.9998480545370226 0.0029985779566460737 27.905187100600692 0.21128732669383016 219.26326600017012 0.0071838554939596365 1.0000000000000041e-14 13.999999999999998 -9.394287551382256 MNESK(ub)AWEVDTCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MNESKAWEVDTCR 13 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 18621100.0 6491800.0 3430800.0 8698500.0 True False 5398219.335502563 3412317.599439522 10517316.132680181 1.0 0.6321191095363008 1.9482935907236605 22.364052165583036 -6.832103737650963 1.3184998193182982 0.8037000281678746 1.9852542873017227 0.9100172782769619 0.1663244164719234 0.17822678598197922 0.6052156624228838 0.09902386425184581 0.22787635040880952 1.4719608608464528e-07 6.832103737650963 1.1815542591338482 MNESK(ub)AWEVDTCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MNESKAWEVDTCR 13 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 13320000.0 5297100.0 2588100.0 5434800.0 True False 6857200.371451357 2444069.9598772554 4445722.165757153 1.0 0.35642387964229155 0.6483290446442352 22.70918824854643 -10.46823398578765 6.193075229634651 1.0002532992967017 0.502376462143356 0.7948662754214935 0.11916978458961547 0.00041698804768833264 3.58046222621261e-05 0.11544286569813299 0.0384618825905588 3.4022483663349545e-11 10.46823398578765 -0.49787683715334574 MNGDQNSDVYAQEK(ub)QDFVQHFSQIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MNGDQNSDVYAQEKQDFVQHFSQIVR 26 1 P14324;P14324-2;A0A087WVN4;A0A087X1D8;A0A087WTP2 P14324 FDPS Farnesyl pyrophosphate synthase 1 54510300.0 11363000.0 7061300.0 36086000.0 True False 11002287.78479173 9880913.914193042 26633994.04320507 1.0 0.8980781186119541 2.4207687132144255 23.391300209106348 -6.890884559645245 1.0170968658623778 0.919910927421637 2.554045685359002 0.98145977987974 0.0946365506171611 0.11842990259190321 0.2176603178589215 0.07081027356992878 0.1771092737612553 1.2856283489948207e-07 6.890884559645245 1.6341347579373648 up MNGDQNSDVYAQEK(ub)QDFVQHFSQIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MNGDQNSDVYAQEKQDFVQHFSQIVR 26 1 P14324;P14324-2;A0A087WVN4;A0A087X1D8;A0A087WTP2 P14324 FDPS Farnesyl pyrophosphate synthase 1 72400600.0 9278600.0 18311000.0 44811000.0 True False 14076314.556522246 15043258.985504018 35954086.208640985 1.0 1.0686930108800203 2.5542258283779042 23.746766322973002 -6.916558675657277 0.8498528156900621 0.9629840288694146 2.7757987929906256 0.99317048661096 0.059255702382949096 0.10023928277257944 0.11641726620735195 0.05014539799480567 0.14560560060829003 1.21182895272295e-07 6.916558675657277 1.8128147641212111 up MNGDQNSDVYAQEK(ub)QDFVQHFSQIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MNGDQNSDVYAQEKQDFVQHFSQIVR 26 1 P14324;P14324-2;A0A087WVN4;A0A087X1D8;A0A087WTP2 P14324 FDPS Farnesyl pyrophosphate synthase 1 50322800.0 11363000.0 8969800.0 29990000.0 True False 9448837.966252126 8921477.907034094 36260770.34190708 1.0 0.9441878397003342 3.8375904498963362 23.171705484540624 -6.902502434491951 0.9453062881829347 0.8878226816573725 4.157227279477696 0.9877708612958477 0.1494009434293548 0.10958684109014764 0.1672108719753872 0.11795259893367904 0.3109329810880136 1.2516922564948098e-07 6.902502434491951 3.269404597820323 up MNGDQNSDVYAQEK(ub)QDFVQHFSQIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MNGDQNSDVYAQEKQDFVQHFSQIVR 26 1 P14324;P14324-2;A0A087WVN4;A0A087X1D8;A0A087WTP2 P14324 FDPS Farnesyl pyrophosphate synthase 1 61259600.0 9278600.0 20334000.0 31647000.0 True False 12011330.608549697 19202395.024977442 25887570.725641515 1.0 1.5986900744626182 2.1552625241382226 23.51789264506545 -6.972002397203848 0.20478645699760425 0.6885019886024779 3.0808981213459097 0.9999940761920743 0.0011481436751919112 0.07565815049677715 0.00665171568201404 0.017377954932737093 0.058390820801549545 1.0665902338856648e-07 6.972002397203848 2.392396132743432 MNGSTLNK(ub)DESKEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MNGSTLNKDESKEER 15 2 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;A0A0A0MRS6;Q86UV5-5 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 2527700.0 700950.0 612050.0 1214700.0 True False 907393.5927901737 577988.8794648092 993637.0638745145 1.0 0.6369770340647134 1.095045272271703 19.791368947126927 -6.695522788731356 1.8470750640855453 0.7735937996068599 1.0935640724770568 0.3962878039132074 0.15336562662249903 0.4048901807748668 2.682359680700446 0.06632504568508485 0.17150437529100795 2.0159381855784364e-07 6.695522788731356 0.31997027287019686 MNK(ub)GEPQPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MNKGEPQPR 9 1 H0Y7D7;Q99941-2;Q99941 H0Y7D7 ATF6B Cyclic AMP-dependent transcription factor ATF-6 beta;Processed cyclic AMP-dependent transcription factor ATF-6 beta 1 2144200.0 121660.0 430740.0 1591800.0 True False 117797.96989331719 602736.7282794265 1174859.8270236058 1.0 5.116698775244516 9.973515062166253 16.845955150701272 -6.998431006094557 0.28683113708535235 1.1434293807292292e-18 15.097540042646614 0.9999748440540999 0.018394971028269102 0.07371755843976396 0.010341041318970604 0.0864864994113101 0.42794539226382744 1.0036192757959341e-07 6.998431006094557 15.097540042646614 MNK(ub)GEPQPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MNKGEPQPR 9 1 H0Y7D7;Q99941-2;Q99941 H0Y7D7 ATF6B Cyclic AMP-dependent transcription factor ATF-6 beta;Processed cyclic AMP-dependent transcription factor ATF-6 beta 1 1576610.0 121660.0 440550.0 1014400.0 True False 101165.68045183796 438176.66970767174 1226506.349944331 1.0 4.331277838004311 12.123739438773754 16.626360426135548 -6.956870799422136 0.4775030908166673 0.8084922858542787 15.970041441366746 0.999635933237252 0.08894190804814762 0.08083857413497048 0.025410519677829434 0.10932102273428886 0.6428749989344825 1.1044071269917193e-07 6.956870799422136 15.161549155512468 MNK(ub)SEDDESGAGELTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MNKSEDDESGAGELTR 16 1 P33993;P33993-3;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 24530500.0 6182600.0 6274900.0 12073000.0 True False 8105448.472383578 5338709.379368621 10823801.772393519 1.0 0.6586568772299728 1.3353735834940854 22.950460581221712 -6.769574026921662 1.5761363153106733 0.804108614350266 1.3391144112920048 0.7289172195732103 0.1438427147219065 0.2671150361627603 1.3095201366592952 0.07193934284262331 0.17130886364559977 1.6999101736705705e-07 6.769574026921662 0.5350057969417388 MNK(ub)SEDDESGAGELTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MNKSEDDESGAGELTR 16 1 P33993;P33993-3;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 39089900.0 4391300.0 6574600.0 28124000.0 True False 4251900.5851760935 9199872.066086072 20757480.69808516 1.0 2.1637081775055327 4.881929923398123 22.019676434549222 -6.956900189911279 0.47711709961000387 0.9329516392775813 6.225465885342618 0.9996373991675878 0.030973768418058264 0.08082757763663749 0.02536801624883614 0.038104865710160286 0.22425641386460102 1.1043323897598793e-07 6.956900189911279 5.2925142460650365 MNK(ub)SEDDESGAGELTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MNKSEDDESGAGELTR 16 1 P33993;P33993-3;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 230685000.0 12710000.0 23805000.0 194170000.0 True False 19281999.22546481 19556811.76068607 155792214.3922656 1.0 1.0142522843200994 8.079671229657468 24.200751307228206 -6.907340118443414 0.913659190044414 0.7624120261742227 8.942650595834447 0.9898783552960012 0.3354251891533876 0.10620356866064706 0.14850372681812754 0.2710547876090495 0.7351359926161508 1.237826800724375e-07 6.907340118443414 8.180238569660224 up MNK(ub)SEDDESGAGELTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MNKSEDDESGAGELTR 16 1 P33993;P33993-3;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 26740200.0 6182600.0 5066600.0 15491000.0 True False 8468474.298482725 4842740.858994332 11832344.847159583 1.0 0.5718551758327935 1.3972227381359064 23.013670642744604 -6.765706222475054 1.5908995416932086 0.7530972113909647 1.4011346909618563 0.7139517286163455 0.18025736042006077 0.2733836899788614 1.3648345551276355 0.08934787280738393 0.21353293295286663 1.7151171022980574e-07 6.765706222475054 0.6480374795708915 MNK(ub)SEDDESGAGELTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MNKSEDDESGAGELTR 16 1 P33993;P33993-3;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 38858300.0 4391300.0 9960000.0 24507000.0 True False 3651560.517574847 9906343.503094802 29631300.39243468 1.0 2.7129068395322706 8.114695141931827 21.8000817099835 -6.950323078594454 0.5552848959120166 0.9275299792254709 10.15615164464028 0.9992263975754082 0.08432863737211703 0.08335625855310341 0.03542739468590756 0.0909191380959255 0.4485892703663616 1.1211840772631694e-07 6.950323078594454 9.22862166541481 MNK(ub)SEDDESGAGELTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MNKSEDDESGAGELTR 16 1 P33993;P33993-3;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 306618000.0 12710000.0 12558000.0 281350000.0 True False 16453345.55155591 11859136.260630798 230147186.89478448 1.0 0.7207735486664801 13.987865639460823 23.971877629320655 -6.902095485576821 0.947947684298747 0.47966617419700647 15.441170839648134 0.9875796574332192 0.689787830811953 0.10987860570745887 0.1688578406577139 0.5435378187298912 1.429619918118769 1.252865685015172e-07 6.902095485576821 14.961504665451127 up MNLASEPQEVLHIGSAHNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MNLASEPQEVLHIGSAHNR 19 0 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 0 12104600.0 3187900.0 4163900.0 4752800.0 False True 4179367.771667512 3542662.350755078 4261025.848076869 1.0 0.8476550866787209 1.019538380173893 21.994853286351425 -6.672817646771552 1.9274181073738412 0.9029955462395937 1.0188524548036282 0.2915897288803153 0.06467103717826576 0.45466988443926565 3.259015142286807 0.026986748909493454 0.07183707464773215 2.1241361652001353e-07 6.672817646771552 0.11585690856403452 MNLASEPQEVLHIGSAHNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MNLASEPQEVLHIGSAHNR 19 0 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 0 10401800.0 4291500.0 2469800.0 3640500.0 False True 4155268.681548332 3456004.0198368514 2686943.837341022 1.0 0.8317161379198899 0.6466354027291963 21.98651033464833 -6.969902154501775 0.26051451255616015 1.051636243059494 0.4212205559040392 0.9999816073274763 0.00061889136041084 0.0763344915059826 0.009143781519848765 0.003850804948215699 0.017449218213652213 1.071760743146699e-07 6.969902154501775 -0.6304156871554549 MNLASEPQEVLHIGSAHNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MNLASEPQEVLHIGSAHNR 19 0 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 0 10531900.0 3187900.0 3433000.0 3911000.0 False True 4366552.779758197 3281318.7085871277 2987302.34957337 1.0 0.7514666314805966 0.6841328847372355 22.058063347874317 -13.999999999999995 0.18327061964289704 2.3027920130324397 0.6324141693339181 0.9994945552921248 0.0030539824638841 12.248766005607171 0.1357354664862017 5.68702056742645 0.04891034537391707 1.0000000000000123e-14 13.999999999999995 -1.6703778436985215 MNLASSFVNGFVNAAFGQDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MNLASSFVNGFVNAAFGQDK 20 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 237269000.0 130220000.0 25814000.0 81235000.0 False True 108283699.72413561 25674934.858322185 98220862.91179779 1.0 0.23710803125245858 0.9070696989669361 26.690240845100927 -10.747586801086898 9.661859813068183 1.0015580186239617 0.5720888651101127 0.35230381220238927 0.27351070552075407 0.00920167054400944 0.00024039042518817072 0.26547085803019477 0.08827520062427675 1.7881880937984167e-11 10.747586801086898 -0.42946915351384896 MNLEAHLK(ub)ECEHIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MNLEAHLKECEHIK 14 1 Q6Q0C0;Q6Q0C0-2 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 15240300.0 4582400.0 3799700.0 6858200.0 True False 6007570.776024727 3232799.5711145964 6148579.25249973 1.0 0.5381209296802948 1.023471796127271 22.518350309369854 -10.999744066884418 12.887485331077725 1.2175451580647487 0.7807963629040832 0.2138185661363493 0.19814366150213275 0.05861698428962948 1.164081599023637e-06 0.009080090362890807 0.06395059176285998 1.0005894814526855e-11 10.999744066884418 -0.43674879516066556 MNLEAHLK(ub)ECEHIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MNLEAHLKECEHIK 14 1 Q6Q0C0;Q6Q0C0-2 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 6127430.0 3355300.0 800430.0 1971700.0 True False 3248787.838098365 1120045.8731873084 1455252.6202679002 1.0 0.34475808486247983 0.4479371054035074 21.63147010095169 -10.40695990754235 6.849110353066447 1.0000523585235104 0.39634759513538015 0.9785584114749457 0.04212265874761031 3.3680533287655534e-05 2.9162849971078582e-06 0.04078859876058253 0.013595029652289412 3.917780429359244e-11 10.40695990754235 -0.6037047633881303 MNLEAHLK(ub)ECEHIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MNLEAHLKECEHIK 14 1 Q6Q0C0;Q6Q0C0-2 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 79263700.0 6969700.0 45230000.0 27064000.0 True False 10573544.45332195 37158353.11639704 21714788.537427388 1.0 3.514275963035535 2.0536905702046893 23.33395574084247 -10.06534747024804 6.100602481032215 0.999996456415056 2.7839832666201634 0.665456145388261 0.5962814896998655 2.8739513072524168e-05 4.402698735114423e-06 0.5773482125708161 0.19244902327158392 8.603051639635164e-11 10.06534747024804 1.7839868102051075 MNLEAHLK(ub)ECEHIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MNLEAHLKECEHIK 14 1 Q6Q0C0;Q6Q0C0-2 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 16764300.0 4582400.0 4319600.0 7862300.0 True False 6276637.114703719 4128745.7889929987 6005386.669151298 1.0 0.6577958409163012 0.9567841121614333 22.581560370892745 -10.192884519151846 7.428869143096065 1.0000001945132873 0.8072899776498086 0.3564619984244588 0.12206145060457098 3.932423745475081e-07 4.267120973805081e-08 0.11818561110500861 0.03939516378378523 6.41380099754297e-11 10.192884519151846 -0.19271021686347867 MNLEAHLK(ub)ECEHIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MNLEAHLKECEHIK 14 1 Q6Q0C0;Q6Q0C0-2 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 55390400.0 6969700.0 40719000.0 7701700.0 True False 9022414.043326447 38452951.855122276 6300069.626115378 1.0 4.261936070597928 0.6982687333857518 23.10508206293492 -6.665927363203467 1.9513813907825404 3.089358886469032 0.7127983974291994 0.26115064390153275 1.3869220324344531 0.47064365970891886 3.4509379753199765 0.5729284227497423 1.5391366865650102 2.1581053272756257e-07 6.665927363203467 -2.376560489039832 MNLGVGAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MNLGVGAYR 9 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 96426000.0 24293000.0 30683000.0 41450000.0 False True 31848358.253746632 26105216.00139724 37161151.61647573 1.0 0.8196722667274766 1.1668152976803476 24.924715669339115 -6.765548793329989 1.5917033620327272 0.8959816071980413 1.1684384990349868 0.7131773259464312 0.07591877753660949 0.2736838857888792 1.3677197571659883 0.03761326705057277 0.0898981130544929 1.7157389346598894e-07 6.765548793329989 0.27245689183694544 MNLGVGAYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MNLGVGAYR 9 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 56149500.0 14476000.0 6511500.0 35162000.0 False True 14016467.30376179 9111575.907023914 25952017.36261089 1.0 0.650062223922751 1.8515376806569368 23.74061944397653 -6.828766858663955 1.3334775798916652 0.8128535966014746 1.8830475053218856 0.9033750512230442 0.15683642560757644 0.1823365538283239 0.6345421027858202 0.09235972533554039 0.21255134354366853 1.4833141556733457e-07 6.828766858663955 1.070193908720411 MNLGVGAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MNLGVGAYR 9 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 74467000.0 24293000.0 22818000.0 27356000.0 False True 33274778.5936403 21809825.310964506 20895076.214505013 1.0 0.6554461436787125 0.627955379348448 24.987925730862006 -13.999999999999998 0.3584022908151496 5.463608515731399 0.6245692288849979 0.9997703847893368 0.0025650478886857188 21.525642072513588 0.19335310059155403 73.43785453702228 0.007974568882241326 1.0000000000000041e-14 13.999999999999998 -4.8390392868464005 MNLGVGAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MNLGVGAYR 9 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 35206000.0 14476000.0 9478000.0 11252000.0 False True 12037435.395535149 9426940.132764306 13604741.176630162 1.0 0.7831352628701034 1.1302026328362558 23.521024719410807 -6.7377576689203 1.694981147402865 0.8706328161941045 1.1303056161435165 0.5948201667816233 0.09112316553932162 0.32187904514631954 1.8148736530100826 0.042546024545528145 0.10465916280749589 1.8291205586441918e-07 6.7377576689203 0.25967279994941206 MNLPGEVTFLPLNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MNLPGEVTFLPLNK 14 0 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 0 6262240.0 848940.0 3567300.0 1846000.0 False True 1112968.5611466558 3035072.745226492 1654993.6280823702 1.0 2.727006719848002 1.4870084258061012 20.085981409696394 -10.471800849178525 5.49087462572848 0.9986072474706461 2.107007572826988 0.515191086669406 0.5062271837207247 0.008639213728058853 0.0008310553726865184 0.4906155494677378 0.16338412099565233 3.3744201117244244e-11 10.471800849178525 1.108400325356342 MNLPGEVTFLPLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MNLPGEVTFLPLNK 14 0 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 0 5230340.0 848940.0 1810400.0 2571000.0 False True 1162816.0597408735 1730410.5418077875 1963782.7514070906 1.0 1.4881206079948697 1.6888163308001676 20.149191471219286 -11.246874867739178 0.1646126659182318 8.427036633972092e-19 1.912290123818007 0.9995526386595457 0.006117975015702717 3.6599567507894646 0.09857217928327038 1.5138535418392347 0.1665144716885256 5.6640246175619376e-12 11.246874867739178 1.912290123818007 MNPGPGGK(ub)LGHALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MNPGPGGKLGHALR 14 1 P41440;P41440-2;H3BTQ3;P41440-3 P41440 SLC19A1 Folate transporter 1 1 13757500.0 4470700.0 5573800.0 3713000.0 True False 5861130.994320382 4742210.766502228 3328814.3776109684 1.0 0.8090948267659565 0.5679474457808046 22.48274765077348 -6.967955159518795 0.3030743153273308 1.0403240394237545 0.32912885684451193 0.9999617516267759 0.0010932965783870552 0.07697195382610149 0.011392446659062205 0.003940966132116545 0.021558045789856956 1.076576363350016e-07 6.967955159518795 -0.7111951825792426 MNPGPGGK(ub)LGHALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MNPGPGGKLGHALR 14 1 P41440;P41440-2;H3BTQ3;P41440-3 P41440 SLC19A1 Folate transporter 1 1 16420300.0 3463900.0 5771200.0 7185200.0 True False 3353940.3905430012 8075670.256410418 5303180.568620442 1.0 2.407815678293248 1.5811791359123888 21.677425617489337 -10.226400881482581 5.118302398306065 0.9998908334887002 1.9944974071032877 0.6586821261826517 0.3374729552635782 0.0004204387137049837 6.354659955065819e-05 0.3267920977876961 0.10891892796070192 5.937438421858343e-11 10.226400881482581 0.9946065736145875 MNPGPGGK(ub)LGHALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MNPGPGGKLGHALR 14 1 P41440;P41440-2;H3BTQ3;P41440-3 P41440 SLC19A1 Folate transporter 1 1 21079300.0 6229900.0 7982900.0 6866500.0 True False 9451213.766697342 6558289.12431762 5509333.265306134 1.0 0.6939097227307098 0.5829233579203373 23.172068187837624 -13.999999999999998 0.14113764555916616 2.463677276742009 0.4474363752401935 0.9995984365752397 0.003534312166935365 11.935314598423007 0.11778661292166365 4.808224031053845 0.12121843636201121 1.0000000000000041e-14 13.999999999999998 -2.0162409015018157 MNPGPGGK(ub)LGHALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MNPGPGGKLGHALR 14 1 P41440;P41440-2;H3BTQ3;P41440-3 P41440 SLC19A1 Folate transporter 1 1 11634100.0 4470700.0 4059700.0 3103700.0 True False 6123638.606124714 3880329.0303673684 2370669.982707971 1.0 0.6336639504634316 0.38713420813842353 22.54595771229637 -8.23089904576579 0.1716227307251098 1.3343802548421464 8.540182822627725e-11 0.9998792702790864 0.0027665880713663702 0.08624340019347415 0.03563070663430439 0.11702647123384899 0.12301192270455036 5.8762593366105365e-09 8.23089904576579 -1.3343802547567445 down MNPGPGGK(ub)LGHALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MNPGPGGKLGHALR 14 1 P41440;P41440-2;H3BTQ3;P41440-3 P41440 SLC19A1 Folate transporter 1 1 14069500.0 3463900.0 7078800.0 3526800.0 True False 2880386.326788769 7040665.09936822 4264237.573919233 1.0 2.4443474939063417 1.4804394585059935 21.457830892923614 -10.51547672126469 5.526783302375509 0.9979793548195696 1.9623934762054651 0.5706581923548935 0.39351380761657834 0.009811905847220085 0.0008601901867975262 0.3815639464664698 0.12700603528347235 3.0515695927597274e-11 10.51547672126469 0.9644141213858956 MNPGPGGK(ub)LGHALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MNPGPGGKLGHALR 14 1 P41440;P41440-2;H3BTQ3;P41440-3 P41440 SLC19A1 Folate transporter 1 1 16813600.0 6229900.0 6892900.0 3690800.0 True False 8064728.359688289 6509304.05565393 3019112.2708060057 1.0 0.807132461917852 0.37436006969522995 22.943194509930073 -6.957733831766206 0.4662757721015273 1.0118542836004827 0.1520075524089812 0.9996766944361724 0.004703763220874509 0.08052080098024045 0.024199341757811934 0.005942757739679526 0.0357295168756231 1.1022146223739e-07 6.957733831766206 -0.8598467311915015 down MNTLQAIWMMDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MNTLQAIWMMDPK 13 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 8633100.0 1724200.0 3651400.0 3257500.0 False True 2260442.8971765535 3106625.35304572 2920445.148146439 1.0 1.3743436549209476 1.2919791744327065 21.10817404238883 -10.139838302761419 4.529453250685063 0.9999576755667968 1.3331614146849453 0.9561704389048679 0.033625158381895816 23498338.52753398 0.9349407738027815 10372.696850401577 0.011510786086784854 7.247057334859116e-11 10.139838302761419 0.3332037391181485 MNTLQAIWMMDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MNTLQAIWMMDPK 13 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 7805000.0 2907200.0 1499100.0 3398700.0 False True 2814912.5273208227 2097698.4477032246 2508478.511185533 1.0 0.7452091059112845 0.8911390627022618 21.424658660950744 -10.177504757870278 5.036726915954929 1.00001309095836 0.8181740844590326 0.674262572801787 0.05957565538818191 8.758390286613718e-06 1.4302330649554821e-06 0.05768803256364899 0.019227960096370466 6.645003929995159e-11 10.177504757870278 -0.18183900649932738 MNTLQAIWMMDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MNTLQAIWMMDPK 13 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 9043500.0 1724200.0 2981800.0 4337500.0 False True 2361683.334753002 2850054.2165060034 3313071.833616591 1.0 1.2067893161485503 1.4028433807630227 21.17138410391172 -6.9717713451475065 0.21164388281994684 0.89948271938951 1.7156332143704016 0.9999930988965744 0.00043204849703062107 0.07573198453190778 0.006934699471763608 0.005795008809429587 0.02023939652482792 1.0671578290158857e-07 6.9717713451475065 0.8161504949808916 MNTTLSSLK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MNTTLSSLKEK 11 1 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 1 15765300.0 1955100.0 2984200.0 10826000.0 True False 2966029.636955645 2451646.1943389764 8686236.354795635 1.0 0.8265750833344215 2.9285736887346996 21.500101582786076 -6.88688402821131 1.0406109793467013 0.8784774718521194 3.098720515428419 0.978828851138013 0.1386134547527506 0.12170894741087188 0.23689311216872252 0.10188412563556845 0.25131674063902254 1.297525709389747e-07 6.88688402821131 2.2202430435763 up MNTTLSSLK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MNTTLSSLKEK 11 1 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 1 14586000.0 1955100.0 2331900.0 10299000.0 True False 2530915.4907826087 2202127.715095156 8424687.676663894 1.0 0.8700913654032023 3.328711569922398 21.271227904878526 -6.894432094951904 0.9958231024392566 0.8815860485522212 3.5594675538803657 0.9835858592750149 0.14472565202164112 0.11561968246967884 0.20144424481114578 0.11004312650855519 0.2790907435359321 1.2751694662225344e-07 6.894432094951904 2.6778815053281444 up MNVLADALK(ub)SINNAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MNVLADALKSINNAEK 16 1 P62244;I3L3P7;I3L246;H3BV27;H3BT37;I3L303;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 1 19135000.0 4675800.0 5681000.0 8778200.0 True False 4527369.288403519 7949452.926023625 6478926.079644817 1.0 1.7558658063051071 1.431057567192508 22.110241558441253 -10.210751405934149 5.063142537039184 0.9999401154892537 1.5934616867492544 0.8165517134859641 0.13260240834784867 8.964598837576055e-05 1.3974571566222014e-05 0.12840462316625476 0.042797243266295214 6.155291062836072e-11 10.210751405934149 0.5935215712600007 MNVLADALK(ub)SINNAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MNVLADALKSINNAEK 16 1 P62244;I3L3P7;I3L246;H3BV27;H3BT37;I3L303;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 1 16657200.0 4675800.0 7781000.0 4200400.0 True False 3888134.873061842 7739082.2085924335 5078684.219544725 1.0 1.99043563591662 1.3062006296981525 21.89064683387553 -10.50340770385521 5.110133703360506 0.9981200983068181 1.6483181328073986 0.5448397711447942 0.2793377715642628 0.0059971102168536764 0.0005827865546802741 0.2711181150623508 0.09015587810291731 3.1375618530988674e-11 10.50340770385521 0.6501980345005804 MNVLADALK(ub)SINNAEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 MNVLADALKSINNAEKR 17 2 P62244;I3L3P7;I3L246;H3BV27;H3BT37;I3L303;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 2 4480790.0 775690.0 3705100.0 0.0 True False 1016937.1017926445 3152313.522366681 0.0 1.0 3.0998116961312756 0.0 19.955799019671968 -6.724321532462303 1.7439641578222511 2.271670464905707 0.0037690871728340626 0.5325498785706397 0.8831877503383673 0.34709261361319504 2.0653415203269745 0.4017679403690835 1.0034219326559128 1.8865940809491806e-07 6.724321532462303 -2.267901377732873 MNVLADALK(ub)SINNAEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MNVLADALKSINNAEKR 17 2 P62244;I3L3P7;I3L246;H3BV27;H3BT37;I3L303;H3BN98 P62244;H3BN98 RPS15A 40S ribosomal protein S15a 2 4686090.0 775690.0 1778700.0 2131700.0 True False 1062483.5552340522 1700111.1526256725 1628236.3637395944 1.0 1.6001293801212375 1.5324814729776346 20.01900908119486 -10.244418217184693 5.272741802790391 0.999941244632595 1.5663054265495155 0.9894112327354844 0.02761714244517273 1.90776615858043e-05 2.7338480752507455e-06 0.026742943681710783 0.008913394396617163 5.6961547939718216e-11 10.244418217184693 0.5663641819169205 MNYFQVAK(ub)TVAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MNYFQVAKTVAQR 13 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 13682000.0 4702400.0 5433900.0 3545700.0 True False 6164891.938106371 4623183.301176305 3178824.9767560465 1.0 0.7499212228846265 0.5156335275087507 22.555644175756928 -6.97191204718912 0.20749673430056326 1.12664928912101 0.13238333087193022 0.9999937041692646 0.0004962179786773121 0.07568700355647293 0.00676283860291635 0.007157316134494782 0.024420470470642112 1.0668121489042104e-07 6.97191204718912 -0.9942659582490798 MNYFQVAK(ub)TVAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MNYFQVAKTVAQR 13 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 27036500.0 8831600.0 9331800.0 8873100.0 True False 8551245.69217343 13058036.404694121 6548968.922705839 1.0 1.5270332387532208 0.7658496970447025 23.027703167453193 -6.7204635821663326 1.757663567592423 1.3204854761130433 0.7670080092119088 0.5146667523618405 0.22176550390924954 0.3544331588102789 2.1402008789136673 0.10017168604082474 0.2513298373889626 1.903427843132471e-07 6.7204635821663326 -0.5534774669011345 MNYFQVAK(ub)TVAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MNYFQVAKTVAQR 13 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 41142000.0 10582000.0 14981000.0 15579000.0 True False 16053667.64782599 12307523.502912767 12499803.82148174 1.0 0.7666487043899572 0.778626049554133 23.936399599743222 -9.977217454470486 6.816338296480499 1.000000024270982 0.7726373769740181 0.9979229742603671 0.004889730687573429 1.8066426644763505e-09 2.690995718186222e-10 0.00473446194449257 0.001578153793367147 1.0538590891959403e-10 9.977217454470486 -0.22736264729696376 MNYFQVAK(ub)TVAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MNYFQVAKTVAQR 13 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 16197400.0 4702400.0 4689400.0 6805600.0 True False 6441004.357581775 4482206.8022279255 5198257.445731663 1.0 0.6958863173181792 0.8070569676936702 22.61885423727982 -10.348905461353029 5.05818509410745 1.0001264792435147 0.7514716425058863 0.8695133926586494 0.04538522796568346 6.476645065483602e-05 8.336818055672608e-06 0.04396632502520353 0.014648019339557464 4.478107744850127e-11 10.348905461353029 -0.24865483673762845 MNYFQVAK(ub)TVAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MNYFQVAKTVAQR 13 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 22442000.0 8831600.0 8773600.0 4836800.0 True False 7343866.706217753 8726334.87537675 5848152.517163591 1.0 1.1882479931162855 0.7963315173207323 22.80810844288747 -6.776071114343352 1.5509607634654725 1.1071336606376643 0.7935890710751733 0.7533219189121807 0.07948683502919442 0.25672408332122376 1.219425291379329 0.04037571770451548 0.09559597717989847 1.6746686318991657e-07 6.776071114343352 -0.313544589562491 MNYFQVAK(ub)TVAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MNYFQVAKTVAQR 13 1 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 33173500.0 10582000.0 14470000.0 8121500.0 True False 13698607.602404753 13664731.77984772 6643470.333627132 1.0 0.9975270608852913 0.4849741321490871 23.70752592183567 -6.907958689522923 0.9095245928657456 1.0169122863751077 0.42154819965180934 0.9901281398496959 0.02406479350113114 0.10578338869229284 0.14620436273239493 0.01950543636066368 0.0531118395769633 1.2360650034543617e-07 6.907958689522923 -0.5953640867232983 down MNYSDAIVWLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MNYSDAIVWLK 11 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 19742000.0 6084600.0 6949300.0 6708100.0 False True 7976969.523350225 5912491.528159241 6014010.16063887 1.0 0.741195200865713 0.7539216669983042 22.9274093353197 -9.952779127903835 6.775385040734465 1.0000000202691743 0.7475584339347603 0.9980974824110664 0.005195558042282685 1.5891910717991238e-09 2.434034502127563e-10 0.005030577892769232 0.0016768591476670131 1.1148613820662958e-10 9.952779127903835 -0.25244158633441405 MPDFNSQAQSNLLGK(ub)CR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MPDFNSQAQSNLLGKCR 17 1 P50219 P50219 MNX1 Motor neuron and pancreas homeobox protein 1 1 6599200.0 2253700.0 2204700.0 2140800.0 True False 2182157.5271130074 3085048.207358616 1580060.2573766396 1.0 1.4137605415866252 0.7240816658488711 21.057323821023097 -6.744250685593992 1.671118511112482 1.2449733699675467 0.7232923638415338 0.6238116242106009 0.17383862333683134 0.3102116557196149 1.7025330316889784 0.08224144456517413 0.20088038576522374 1.8019772944179e-07 6.744250685593992 -0.5216810061260129 MPDFNSQAQSNLLGK(ub)CR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MPDFNSQAQSNLLGKCR 17 1 P50219 P50219 MNX1 Motor neuron and pancreas homeobox protein 1 1 29283500.0 4971500.0 4681000.0 19631000.0 True False 7542128.965334252 3845638.9771800716 15750924.245427042 1.0 0.5098877246538359 2.0883923250083263 22.84654038912985 -6.823297849995192 1.3575078032587795 0.7366761125871581 2.125362834880065 0.89180913893304 0.21698127118837546 0.18922982202563682 0.6842868509006613 0.12557374584596726 0.28920977338764525 1.5021114272379689e-07 6.823297849995192 1.388686722292907 up MPDFNSQAQSNLLGK(ub)CR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MPDFNSQAQSNLLGKCR 17 1 P50219 P50219 MNX1 Motor neuron and pancreas homeobox protein 1 1 8106100.0 2253700.0 2090500.0 3761900.0 True False 1874051.405838458 2079238.0615682406 4548495.896939649 1.0 1.1094882750230541 2.4270923853898414 20.837729096457373 -6.923352388464221 0.7994677216622077 0.9742888840536532 2.6568654459109404 0.9950626886926551 0.04556564130357839 0.09623909490512608 0.09568494710650716 0.03997337753893248 0.1238622484441999 1.1930196901742726e-07 6.923352388464221 1.6825765618572872 up MPDFNSQAQSNLLGK(ub)CR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MPDFNSQAQSNLLGKCR 17 1 P50219 P50219 MNX1 Motor neuron and pancreas homeobox protein 1 1 41324100.0 4971500.0 2456600.0 33896000.0 True False 6435704.752915834 2319888.0504750446 27727275.80233024 1.0 0.3604714851817852 4.308351123436451 22.6176667112223 -6.86537887859907 1.158339752482402 0.6467090676146217 4.520054226374355 0.9598451548119528 0.3466937521497064 0.14135837310065788 0.3574146048579973 0.23288647741899152 0.5473284249436402 1.363393193097121e-07 6.86537887859907 3.873345158759733 up MPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQK(ub)TYQGSYGFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFR 45 1 P04637;P04637-4;P04637-3;P04637-2;P04637-6;P04637-5;J3KP33;A0A0U1RQC9;A0A087WZU8;E7EQX7;E7EMR6;S4R334;E9PCY9 P04637 TP53 Cellular tumor antigen p53 1 35580900.0 9317200.0 4860700.0 21403000.0 True False 9021430.585977431 6801602.858215632 15796912.223763192 1.0 0.7539383907456745 1.7510429275282915 23.10492479833074 -6.8414184183819025 1.27580200797801 0.8691173114125327 1.7847681682399699 0.926865468380036 0.11469394967374712 0.16714724750783808 0.5278679294491879 0.07047620975271025 0.16242948157364484 1.4407266233331015e-07 6.8414184183819025 0.9156508568274372 MPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQK(ub)TYQGSYGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFR 45 1 P04637;P04637-4;P04637-3;P04637-2;P04637-6;P04637-5;J3KP33;A0A0U1RQC9;A0A087WZU8;E7EQX7;E7EMR6;S4R334;E9PCY9 P04637 TP53 Cellular tumor antigen p53 1 38032600.0 9317200.0 9353400.0 19362000.0 True False 7747664.621945291 9303011.377695471 23410504.680226885 1.0 1.2007503979127665 3.021620813827761 22.885330073765015 -6.927837531852516 0.7643287096764886 0.9699752040884649 3.3756569114726465 0.9960959770461075 0.05682032285968397 0.09377641704270799 0.0832943671652865 0.051115107608769014 0.16675954945031354 1.1807622723494425e-07 6.927837531852516 2.4056817073841814 up MPEINAK(ub)VAESTEEPAGSNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MPEINAKVAESTEEPAGSNR 20 1 H3BTA8;H3BP08;Q15011-3;Q15011-2;Q15011 H3BTA8 HERPUD1 Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein 1 4648600.0 0.0 2883400.0 1765200.0 True False 0.0 2867866.551889912 2134295.1586373555 0.0 MPEK(ub)EPPPPYLPA ddPTM_RPMI8226_Bortezomib_1h_R1 1 MPEKEPPPPYLPA 13 1 Q15012 Q15012 LAPTM4A Lysosomal-associated transmembrane protein 4A 1 21271000.0 6731700.0 7220700.0 7318600.0 True False 8825323.889875531 6143399.706068158 6561341.476968381 1.0 0.6961103958026862 0.7434674986258119 23.073217795667496 -10.226165645782043 5.4188650894276735 1.000017954829887 0.7197889472142645 0.9790272296845229 0.01933345626896133 4.194009414286914e-06 5.988999468355441e-07 0.0187207370936857 0.006239846179512059 5.940655307805174e-11 10.226165645782043 -0.28022900761562264 MPEK(ub)EPPPPYLPA ddPTM_RPMI8226_Bortezomib_2h_R1 1 MPEKEPPPPYLPA 13 1 Q15012 Q15012 LAPTM4A Lysosomal-associated transmembrane protein 4A 1 12141200.0 4758200.0 3572800.0 3810200.0 True False 4607153.545506999 4999437.671905865 2812194.3164501456 1.0 1.0851467446274783 0.6103973502668826 22.135444249673526 -6.860521801627253 1.183195076994174 1.0462572154448713 0.5871881205696325 0.9542663565848796 0.04419810867515449 0.14625886902326743 0.3887926627527644 0.029130336611095684 0.06803480767320289 1.3787267390087863e-07 6.860521801627253 -0.4590690948752387 MPEK(ub)VTWMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MPEKVTWMR 9 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 10662800.0 1453800.0 3271600.0 5937400.0 True False 1905945.8786192264 2783490.0325969174 5323054.803562443 1.0 1.4604244872962673 2.7928677636002766 20.8620757222781 -6.952257561494782 0.5334916506373085 0.9794982458308572 3.334643399228067 0.9993667026433498 0.019131902611802115 0.0825918369575264 0.03230820289206011 0.02123622684531301 0.1102375839862509 1.116201080295834e-07 6.952257561494782 2.35514515339721 up MPEK(ub)VTWMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MPEKVTWMR 9 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 10620600.0 2254700.0 2594200.0 5771700.0 True False 2183125.782660384 3630077.5885742786 4259918.622711485 1.0 1.6627890236130238 1.9512932587513558 21.05796382415705 -10.458153763822205 0.17845304737212755 1.3225196278045087e-23 2.252560377370525 0.9995189977605705 0.008734491949966124 2.206002649552387 0.09157660034634017 1.186043554158534 0.2071446583048603 3.482140065472874e-11 10.458153763822205 2.252560377370525 MPEK(ub)VTWMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MPEKVTWMR 9 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 24372900.0 2574300.0 6587600.0 15211000.0 True False 3905401.3065392603 5411991.310846278 12204539.182781855 1.0 1.3857708558104802 3.125040994467431 21.897039372033774 -6.9421366799358 0.6393757251178732 0.9809676675249923 3.6250995378606854 0.9984305970432839 0.036618460210827514 0.08680522682900789 0.05027099209897566 0.03625135092226076 0.1483434875816903 1.14251870793344e-07 6.9421366799358 2.644131870335693 up MPEK(ub)VTWMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MPEKVTWMR 9 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 9887000.0 1453800.0 1981800.0 6451400.0 True False 1991309.1474677594 1894237.5230637856 4927712.190753685 1.0 0.9512523585162984 2.4746093277480252 20.92528578380099 -6.899508381362695 0.9643847472935094 0.9358072066234558 2.632916441133677 0.9863197241957573 0.08268183166413194 0.11176757356245215 0.17947396841213603 0.06436194733428437 0.16704700223191266 1.260351314390763e-07 6.899508381362695 1.6971092345102212 up MPEK(ub)VTWMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MPEKVTWMR 9 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 8153900.0 2254700.0 2565900.0 3333300.0 True False 1874882.9501459734 2552076.9874087265 4030277.618562145 1.0 1.3611927012350444 2.1496155897350064 20.838369099591326 -6.958298995843318 0.45878435382804006 0.9767377640412866 2.5657883172124762 0.9997017963758867 0.008289086706788747 0.0803145345391318 0.023420055969333567 0.01068572594888184 0.06514043079836632 1.100781201069219e-07 6.958298995843318 1.5890505531711896 up MPEK(ub)VTWMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MPEKVTWMR 9 1 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 1 17665600.0 2574300.0 6689100.0 8402200.0 True False 3332482.0970393647 6316845.704808524 6873085.813852347 1.0 1.8955377766081685 2.0624524344657447 21.668165694126223 -10.87152865003807 0.32259656538646914 3.220406141156494e-11 2.1021275696855684 0.9992466391125516 0.012804394668180119 2.6276879431337914 0.161294113032536 2.0498299429469315 0.05478209670240272 1.3442230864910647e-11 10.87152865003807 2.1021275696533643 MPEMNIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MPEMNIK 7 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 13409880.0 682480.0 7339500.0 5387900.0 False True 894737.8891457216 6244475.20914692 4830411.792386243 1.0 6.979111184292222 5.398689215003767 19.771105585402967 -9.417711979992632 7.701515706646749 0.9999777509829412 6.188900199656012 0.9349503039746981 0.6452045673269696 0.0 0.0 0.6247166359693722 0.20823887865645735 3.821976566930827e-10 9.417711979992632 5.188922448673071 MPEMNIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MPEMNIK 7 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 17496400.0 6573400.0 1671600.0 9251400.0 False True 6364731.015097243 2339078.59727884 6828180.803949113 1.0 0.36750627665654817 1.0728152985181243 22.601668113869458 -6.670370190645237 1.9363393257576451 0.5963970307966793 1.0699491248319273 0.28052338271771027 0.26864920205472587 0.46029583821721 3.3276938104824407 0.11168707452164586 0.2982256181994182 2.1361404767982312e-07 6.670370190645237 0.473552094035248 MPEMNIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MPEMNIK 7 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 19879380.0 682480.0 9028900.0 10168000.0 False True 934811.2993285162 8629973.343420422 7766527.816533389 1.0 9.231781162272442 8.308123598968217 19.83431564692586 -9.832701720342824 7.457079986236308 0.9999999846615755 8.76995238062035 0.9895125993633429 0.37708162119303534 9.516926171466502e-08 1.7509895542352915e-08 0.365107709760324 0.12170256992011651 1.4699355037412598e-10 9.832701720342824 7.769952395958774 MPFGQLMSEFGGSGTGGWVHGVSFSASGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MPFGQLMSEFGGSGTGGWVHGVSFSASGSR 30 0 A0A1W2PNV4;Q92747;E9PF58;Q92747-2 A0A1W2PNV4 ARPC1A Actin-related protein 2/3 complex subunit 1A 0 45776000.0 0.0 14919000.0 30857000.0 False True 0.0 12256587.887320956 24758100.42489648 0.0 MPFLSISSPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MPFLSISSPK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 35546000.0 11352000.0 11653000.0 12541000.0 False True 14882581.932924386 9914417.823038239 11243377.621766536 1.0 0.6661759275186522 0.7554722475199733 23.82712150105351 -9.983335663444894 6.7403713183474725 1.0000000405944796 0.710824087519312 0.9332570429661339 0.03645506998525849 2.2233128776633696e-08 3.3554319470071986e-09 0.03529747446817646 0.011765823244810247 1.0391167286678609e-10 9.983335663444894 -0.2891759530751675 MPFLSISSPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MPFLSISSPK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 16323100.0 0.0 2968100.0 13355000.0 False True 0.0 4153277.808437023 9856924.858587932 0.0 MPFLSISSPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MPFLSISSPK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 19248000.0 4728000.0 8666400.0 5853600.0 False True 7172721.663099733 7119813.209107746 4696633.394275982 1.0 0.9926236571726774 0.6547909726426363 22.774089217513417 -6.911611801752545 0.88469076252713 1.0099342930311561 0.6095929851516192 0.9915156527261387 0.014831877140479443 0.1033617022890693 0.1330586017516478 0.012240670090695828 0.03417914084165494 1.2257113234564833e-07 6.911611801752545 -0.4003413078795369 MPFLSISSPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MPFLSISSPK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 42216000.0 11352000.0 12093000.0 18771000.0 False True 15549141.176264975 11558691.273796737 14337676.400880015 1.0 0.7433652536025932 0.9220879943366773 23.890331562576403 -10.032635583230862 5.23730632962421 1.0000014356317062 0.8327266242426549 0.5387396106157032 0.07296325337325067 1.2230716463571085e-06 2.2593095034291014e-07 0.07064697264461546 0.02354878876642013 9.276078532360348e-11 10.032635583230862 -0.16727481138905131 MPFLSISSPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MPFLSISSPK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 12087500.0 0.0 4869700.0 7217800.0 False True 0.0 4843465.959540233 8727008.60866344 0.0 MPFLSISSPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MPFLSISSPK 10 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 15581900.0 4728000.0 5704200.0 5149700.0 False True 6120489.202813244 5386756.255605215 4212507.44038412 1.0 0.8801185782877007 0.6882631928258066 22.545215539605866 -6.964158614588016 0.3722136399431616 1.0143884915437038 0.5472918282839886 0.9998947300929538 0.0013173007304329196 0.07824768797935683 0.01587405982620458 0.0025206102402114535 0.016275023388565565 1.0860289078043924e-07 6.964158614588016 -0.4670966632597152 MPFTEK(ub)IMATPEQVGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MPFTEKIMATPEQVGK 16 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 29947200.0 7441200.0 7037400.0 15468600.0 True False 7204983.179106949 9847470.519556185 11416909.611947084 1.0 1.3667582941917111 1.584585186132551 22.78056363158439 -10.103173223926866 0.09615531242254033 3.890990103511458e-17 2.22045037697951 0.9999348270487176 0.001947385063842751 1.7787762950403658 0.046942968926843145 0.7729251392024771 0.34639169623949434 7.885455333803352e-11 10.103173223926866 2.22045037697951 MPFTEK(ub)IMATPEQVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MPFTEKIMATPEQVGK 16 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 29349900.0 7441200.0 11254100.0 10654600.0 True False 6187687.50105389 11193471.929536058 12882427.598695658 1.0 1.8089911501881082 2.081945411189805 22.560968907018665 -10.579002926642008 0.22905945107222644 1.988428324703812e-17 2.252442309409379 0.9992439828919276 0.012632023215588732 2.3001202454408096 0.11641954836213943 1.4383779179682685 0.13964937966259014 2.6363136200638827e-11 10.579002926642008 2.252442309409379 MPLHTIIPLLQELTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MPLHTIIPLLQELTK 15 0 Q15061 Q15061 WDR43 WD repeat-containing protein 43 0 12100700.0 3071700.0 3164800.0 5864200.0 False True 4659993.471350139 2600016.713304738 4705138.299629834 1.0 0.557944282387897 1.009687744963002 22.1518965029897 -10.939785982497876 11.247168694998276 1.0454554862639667 0.783816013675455 0.2339236286849864 0.18442349632451271 0.1068115949799 0.0005718369831222572 0.09073453000950875 0.059522427492848536 1.1487195635849165e-11 10.939785982497876 -0.2616394725885117 MPLIGLGTWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MPLIGLGTWK 10 0 P14550;Q5T621;V9GYG2;V9GYP9 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 52176000.0 14569500.0 15032500.0 22574000.0 False True 19100755.59123868 12789709.59622604 20238259.0250983 1.0 0.6695918145820654 1.0595527977113839 24.187126373999877 -6.68212860727984 1.893965932644205 0.79135580913644 1.0581085263796717 0.3340988631145303 0.13996867928528703 0.4337842453949027 3.0101400262540863 0.05925562018770394 0.15587832688619876 2.0790809193541554e-07 6.68212860727984 0.2667527172432317 MPLIGLGTWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MPLIGLGTWK 10 0 P14550;Q5T621;V9GYG2;V9GYP9 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 22548100.0 10218000.0 3849600.0 8480500.0 False True 9893635.18305041 5386765.355398802 6259202.64045338 1.0 0.544467756869316 0.6326494281067213 23.23806927200369 -10.1396173206468 5.364852889269318 1.0000091272039153 0.5885585924909643 0.9666963369141752 0.03600001653672509 4.290939237381335e-06 6.881585859431449e-07 0.034857709895198555 0.011618955375257175 7.250745794253818e-11 10.1396173206468 -0.411450534712951 MPLIGLGTWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MPLIGLGTWK 10 0 P14550;Q5T621;V9GYG2;V9GYP9 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 53986500.0 14569500.0 19560800.0 19856200.0 False True 19956237.87593307 18696539.177084524 15166574.511275562 1.0 0.9368769451095929 0.7599916680471237 24.25033643552277 -6.952972886502746 0.5251923085711295 1.0028895997424305 0.6860148610902598 0.9994144094204904 0.0024582638407247815 0.08231346476118562 0.03118833581868319 0.002762431327215067 0.014618897386072121 1.114364102435345e-07 6.952972886502746 -0.31687473865217075 MPLIGLGTWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MPLIGLGTWK 10 0 P14550;Q5T621;V9GYG2;V9GYP9 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 19403500.0 10218000.0 3650500.0 5535000.0 False True 8496719.734151557 3630834.0319324867 6692342.9090515375 1.0 0.4273218542608602 0.7876384202897101 23.018474547437965 -10.45139495727404 6.841552116634515 1.000069271030281 0.6074801372753069 0.6127509066187204 0.14709862210708757 0.00015545073665879184 1.2465321633394538e-05 0.14245259334786367 0.047475876139234034 3.5367555419686906e-11 10.45139495727404 -0.39258913375497406 MPLLSLHLDVK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MPLLSLHLDVK 11 0 Q9NX08 Q9NX08 COMMD8 COMM domain-containing protein 8 0 84925000.0 20752600.0 30946800.0 33225600.0 False True 31483211.418283273 25424101.75154802 26658545.596702166 1.0 0.8075447391235145 0.8467543301894777 24.90807937344721 -10.482623935247974 6.1198771024429695 1.000117867106177 0.8271495346564965 0.9628413792259467 0.01600724852246664 2.5760161093841487e-05 2.1777685335423546e-06 0.015509477840106284 0.005166317245509713 3.2913651376455274e-11 10.482623935247974 -0.17296833244968046 MPLLSLHLDVK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MPLLSLHLDVK 11 0 Q9NX08 Q9NX08 COMMD8 COMM domain-containing protein 8 0 61732300.0 20752600.0 15810900.0 25168800.0 False True 26864649.794903122 14931009.51610191 20588336.653696295 1.0 0.5557864937787012 0.7663727914146271 24.67920569553966 -10.0713262392511 4.927460113527982 1.0000089969363075 0.661079642594177 0.7754632655560394 0.08597149601358413 8.497335675886659e-06 1.601599189373482e-06 0.08324375260251016 0.027747181024534356 8.485428156002099e-11 10.0713262392511 -0.33892935434213056 MPLSK(ub)ELGFSPYMVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MPLSKELGFSPYMVR 15 1 Q8NFN8-2;Q8NFN8 Q8NFN8-2 GPR156 Probable G-protein coupled receptor 156 1 9024000.0 3672700.0 2099900.0 3251400.0 True False 3054012.778197151 2088587.4219024845 3931252.7072249632 1.0 0.6838830003636797 1.2872417349693166 21.542274667805728 -6.764324836232027 1.5959941125385149 0.8173714115160822 1.2899449734564512 0.7084314575243567 0.13305647970482443 0.27571807462557707 1.3850372760594822 0.06574715485609386 0.1573459976449839 1.7205811624167673e-07 6.764324836232027 0.47257356194036904 MPMFIVNTNVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MPMFIVNTNVPR 12 0 P14174 P14174 MIF Macrophage migration inhibitory factor 0 4485200.0 1264300.0 2086700.0 1134200.0 False True 1657509.5434986162 1775372.4938928934 1016843.8640146394 1.0 1.0711084595902212 0.6134769286868292 20.66058574633986 -6.867207824706648 1.1486898150602562 1.0396153075298569 0.5880521376895489 0.9618201067198573 0.03928954941287814 0.1395642077667647 0.3459189683545495 0.02658626215970213 0.06265985661879428 1.357663602821799e-07 6.867207824706648 -0.451563169840308 MPSESAAQSLAVALPLQTK(ub)ADANR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MPSESAAQSLAVALPLQTKADANR 24 1 O43660-2;O43660;D6RA26 O43660-2 PLRG1 Pleiotropic regulator 1 1 7600200.0 1819600.0 3208600.0 2572000.0 True False 2385513.2210314674 2729889.3870248427 2305874.1123661194 1.0 1.144361457717879 0.9666155240879726 21.185868251397252 -6.690706957298771 1.8640228518623279 1.09044711700315 0.9672269338108049 0.3736538275056126 0.06104626376251428 0.41516707976294986 2.7973952721601405 0.026194680011274618 0.06814904885397932 2.0384170474039543e-07 6.690706957298771 -0.12322018319234507 MPSESAAQSLAVALPLQTK(ub)ADANR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MPSESAAQSLAVALPLQTKADANR 24 1 O43660-2;O43660;D6RA26 O43660-2 PLRG1 Pleiotropic regulator 1 1 20027500.0 7250300.0 7946700.0 4830500.0 True False 7020143.195113568 11119858.751493033 3565247.1381062563 1.0 1.5839931526230275 0.5078596032895565 22.74306902788439 -6.759323088331262 1.614928939787565 1.3395025386287367 0.504048193036034 0.6882216901959417 0.24560668811454184 0.2840618937630848 1.4599406783678521 0.12000277993811066 0.2885889377010067 1.7405115582932113e-07 6.759323088331262 -0.8354543455927027 MPSESAAQSLAVALPLQTK(ub)ADANR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MPSESAAQSLAVALPLQTKADANR 24 1 O43660-2;O43660;D6RA26 O43660-2 PLRG1 Pleiotropic regulator 1 1 32079200.0 8360600.0 9675600.0 14043000.0 True False 10822961.512064375 9137144.354464032 11487318.093347989 1.0 0.844236981188452 1.0613839918531591 23.367591985387392 -6.714167376578962 1.780173782150291 0.9046503034812956 1.0609425883889503 0.484903028801278 0.06559683499121291 0.3667843166784014 2.268225919347204 0.02929476868895426 0.07405372637722533 1.931223882177072e-07 6.714167376578962 0.15629228490765468 MQALEPYPANESSK(ub)LVSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQALEPYPANESSKLVSEK 19 1 K7EP06;O43148;O43148-2 K7EP06 RNMT mRNA cap guanine-N7 methyltransferase 1 8087500.0 1943600.0 2201600.0 3942300.0 True False 1881901.4818728524 3080710.36119233 2909693.3635350936 1.0 1.637019998584853 1.5461454234253493 20.843759673833915 -10.600767121543273 6.20719567513219 0.9980325718693163 1.5915827110051013 0.9826101293646636 0.03709938995549722 0.0010126524679535639 6.513137518890224e-05 0.036012222071332096 0.01197377662100797 2.5074534454690524e-11 10.600767121543273 0.593550139135785 MQALEPYPANESSK(ub)LVSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MQALEPYPANESSKLVSEK 19 1 K7EP06;O43148;O43148-2 K7EP06 RNMT mRNA cap guanine-N7 methyltransferase 1 7931000.0 1943600.0 2724600.0 3262800.0 True False 1616189.5160791734 2709922.0390092423 3945036.3945173174 1.0 1.676735316031149 2.4409491308221423 20.62416494926819 -6.969545913089404 0.2688088016008326 0.8072576302597447 3.3333649278430304 0.9999786217789413 0.0027216008750985212 0.07645030503052391 0.009556065182280592 0.015090323357574825 0.07119329891636438 1.072640243606881e-07 6.969545913089404 2.5261072975832857 MQANNAK(ub)AMSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MQANNAKAMSAR 12 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 13442000.0 0.0 7116800.0 6325200.0 True False 0.0 6055001.181069123 5670728.979602721 0.0 MQANNAK(ub)AMSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQANNAKAMSAR 12 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 24756600.0 6091200.0 8003400.0 10662000.0 True False 5897838.19015431 11199199.357179634 7869302.346856206 1.0 1.8988651428035566 1.3342689462035435 22.49175481127889 -10.135965141720531 5.1266422486903815 0.9999770712264373 1.6165670445043603 0.6139139848964481 0.23049543206717663 6.040822934989281e-05 1.0181247275072322e-05 0.2231845266136612 0.07439208081401612 7.311977700990857e-11 10.135965141720531 0.616589973277923 MQANNAK(ub)AMSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MQANNAKAMSAR 12 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 22399400.0 7338100.0 11582200.0 3479100.0 True False 6101955.282949457 11519804.389713304 4206563.724459109 1.0 1.8878873829021345 0.6893796380667367 22.540840176755747 -6.7082818640656 1.801352782584708 1.5468078879527685 0.6923376843702884 0.45693679343696825 0.3742526441537822 0.3785346156245949 2.393277601481385 0.16540349475507476 0.4210767380542357 1.957573764444557e-07 6.7082818640656 -0.85447020358248 MQANNAK(ub)AMSAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MQANNAKAMSAR 12 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 1942700.0 782920.0 693870.0 465910.0 True False 1013505.373660437 655255.5245392494 381119.160640302 1.0 0.6465239766541041 0.37604059193473155 19.950922307396585 -7.7221263223747085 0.20046723281186465 1.2198706975526559 2.57160741766275e-15 0.9999065267236057 0.0024700176494571765 0.13044863506198554 0.02590651254348734 0.05013300223027145 0.08432417629894673 1.89615431034804e-08 7.7221263223747085 -1.2198706975526532 down MQEELNAQVEKHK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 MQEELNAQVEKHK 13 1 A0A182DWI4;E9PN30;Q9BQE4 A0A182DWI4 VIMP Selenoprotein S 1 3106810.0 1218700.0 1040500.0 847610.0 True False 1597727.5019075898 885261.4558372324 759907.4480492414 1.0 0.5540753694107937 0.475617680200133 20.607589941814304 -13.999999999999998 0.244420693833422 4.0160943617238445 0.4423534242962056 0.9995325219394838 0.004993110606518185 13.783614372213616 0.15645559795687436 20.343924337442132 0.03736624188144738 1.0000000000000041e-14 13.999999999999998 -3.573740937427639 MQEELNAQVEKHK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQEELNAQVEKHK 13 1 A0A182DWI4;E9PN30;Q9BQE4 A0A182DWI4 VIMP Selenoprotein S 1 3669940.0 686740.0 1097000.0 1886200.0 True False 664939.814602471 1535037.8207794265 1392147.635212919 1.0 2.3085364826546546 2.093644574502135 19.342864238954405 -10.148518482465656 4.660344398882257 0.9998707727454155 2.2010905285922764 0.9765551910190305 0.08772925418539507 0.00011781166506135042 2.152520556580167e-05 0.08495245605423409 0.0283144950295384 7.103649380394004e-11 10.148518482465656 1.201219755846861 MQEELNAQVEKHK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MQEELNAQVEKHK 13 1 A0A182DWI4;E9PN30;Q9BQE4 A0A182DWI4 VIMP Selenoprotein S 1 3247640.0 686740.0 1401000.0 1159900.0 True False 571054.7377403845 1393452.5349232724 1402429.7272283407 1.0 2.4401382964390534 2.455858667380358 19.12326951438868 -10.794592988258495 0.7892793767883843 3.1734766995240166e-16 2.4525496164952685 0.9999846684016271 0.00267284483930773 2.55723773418663 0.418618616942925 4.846336668278967 0.0022847447034770414 1.6047486231615045e-11 10.794592988258495 2.452549616495268 MQEHSDQVPVGNIPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQEHSDQVPVGNIPR 15 0 P33993;P33993-3;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 10834340.0 2007500.0 697640.0 8129200.0 False True 1943773.0113499418 976211.2901445389 5999918.649227475 1.0 0.5022249431617349 3.086738324996373 20.890428324008667 -6.856783407691395 1.2017877375113486 0.7318892722513366 3.2044723480655386 0.949615981307112 0.25131449949515705 0.1501571406132918 0.41392628202861326 0.16329359703081966 0.3799231325950961 1.3906460043626735e-07 6.856783407691395 2.4725830758142022 up MQEVVANLQYDDGSGMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MQEVVANLQYDDGSGMK 17 0 Q16531;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 0 5224400.0 1344000.0 1930900.0 1949500.0 False True 1761997.0153145157 1642817.2465892504 1747784.4409244768 1.0 0.932360970143873 0.9919338260697894 20.74878004977172 -10.282627155473923 4.584212502876369 1.0000194762607244 0.9621473981066772 0.3499364387502729 0.02432051659033651 4.843618399233755e-06 7.57957247172513e-07 0.023560354729736936 0.007849412977053025 5.2164235214467854e-11 10.282627155473923 -0.03787207815404725 MQEVVANLQYDDGSGMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQEVVANLQYDDGSGMK 17 0 Q16531;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 0 7930150.0 2039500.0 895850.0 4994800.0 False True 1974757.1888658584 1253567.5767960334 3686512.039211906 1.0 0.6347958036886457 1.8668178852556256 20.913243843396515 -6.827289996791435 1.3399649701491614 0.8044647196218744 1.898175894972794 0.9003503827486414 0.1631021279168442 0.18417652047761884 0.6476887517992302 0.09559635674367739 0.22003495251672497 1.4883669002998667e-07 6.827289996791435 1.0937111753509197 MQEVVANLQYDDGSGMK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 2 MQEVVANLQYDDGSGMKR 18 1 Q16531;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 73690900.0 31121800.0 24339900.0 18229200.0 True False 40800981.18393987 20708481.796187118 16343017.250833781 1.0 0.507548622490932 0.4005545155190224 25.28210051082457 -13.999999999999982 0.21454220142144545 3.9025440529734867 0.34024174871252466 0.9994930430517109 0.005877564001596507 12.856885519810918 0.1467773512852814 15.765678020859392 0.061419858583060746 1.0000000000000409e-14 13.999999999999982 -3.562302304260962 MQEVVANLQYDDGSGMK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 4 MQEVVANLQYDDGSGMKR 18 1 Q16531;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 489116800.0 166481700.0 179425200.0 143209900.0 True False 161196829.56097543 251070618.05005714 105698930.98509105 1.0 1.5575406708299149 0.655713460822805 27.264248128140718 -6.73950018559038 1.6888049539346914 1.3319346660789226 0.6552723246343335 0.6025612060835825 0.23425724287010175 0.31872941605673966 1.784758142510295 0.10974977034888729 0.26943496685860474 1.82179629456957e-07 6.73950018559038 -0.6766623414445891 MQEVVANLQYDDGSGMK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 4 MQEVVANLQYDDGSGMKR 18 1 Q16531;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 1488490500.0 459983900.0 528380600.0 500126000.0 True False 697829205.6275594 434086953.67352986 401275876.88698727 1.0 0.6220532906517641 0.5750345122430337 29.378298737732244 -13.999999999999998 0.2939266159156345 4.329916017340914 0.5627211970922817 0.999636252301491 0.003627888755286281 16.203298969191536 0.17201517114754938 32.699652139846236 0.017448511610249046 1.0000000000000041e-14 13.999999999999998 -3.7671948202486325 MQEVVANLQYDDGSGMK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 3 MQEVVANLQYDDGSGMKR 18 1 Q16531;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 114129800.0 43106900.0 44859100.0 26163800.0 True False 59044685.85017057 42877076.63279378 19984449.300375294 1.0 0.7261801128317785 0.33846313199272554 25.815303883993074 -6.966197976545207 0.33686375948502445 1.043611009080746 0.008208387743835394 0.9999357479268643 0.002175482265039389 0.0775568038486304 0.013439604980812175 0.005527273113173285 0.03363689911801452 1.0809410834982591e-07 6.966197976545207 -1.0354026213369105 down MQEVVANLQYDDGSGMK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 4 MQEVVANLQYDDGSGMKR 18 1 Q16531;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 484191300.0 166481700.0 239448700.0 78260900.0 True False 138436909.9398221 238158742.3262541 94624892.35248251 1.0 1.7203413629340658 0.6835235804787576 27.044653403574994 -6.719834953785124 1.7597381844876965 1.438316300446494 0.6851347495480374 0.5118306162432082 0.3031278644692887 0.3556305528823895 2.152126421684457 0.1367745549207424 0.3434441403906445 1.9061849934442372e-07 6.719834953785124 -0.7531815508984566 MQEVVANLQYDDGSGMK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 4 MQEVVANLQYDDGSGMKR 18 1 Q16531;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 1436413600.0 459983900.0 633466600.0 342963100.0 True False 595458226.1882248 598213626.8481052 280547334.8985771 1.0 1.004627361817669 0.4711452836825801 29.149425059824694 -6.904944856058791 0.9294936986007576 1.0192725423081177 0.40917022216911386 0.9888694814771106 0.026417761733638884 0.10785594511739344 0.1576102212668731 0.02110191329734922 0.056398053185208255 1.2446726423256891e-07 6.904944856058791 -0.6101023201390039 down MQFMLLFSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MQFMLLFSR 9 0 A0A5F9ZI43;H7BZG6;A0A5F9ZHX2;A6NH01;A0A5F9ZHW1;P56377 A0A5F9ZI43 AP1S2 AP-1 complex subunit sigma-2 0 23343400.0 6566900.0 6100500.0 10676000.0 False True 9962467.404697461 5011818.111575953 8565883.920542965 1.0 0.5030699632917044 0.859815502784382 23.248071668210645 -9.904424404943363 6.548943768939574 1.0000000212973008 0.6814427330380329 0.5153054883649844 0.14564075662853807 4.518966168651301e-08 7.700673488081809e-09 0.1410160646430219 0.04700535207927481 1.2461651309438084e-10 9.904424404943363 -0.3185572882592679 MQFMLLFSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MQFMLLFSR 9 0 A0A5F9ZI43;H7BZG6;A0A5F9ZHX2;A6NH01;A0A5F9ZHW1;P56377 A0A5F9ZI43 AP1S2 AP-1 complex subunit sigma-2 0 17416600.0 6566900.0 5053300.0 5796400.0 False True 8500981.50295141 4772079.41279229 4741514.676086468 1.0 0.561356287051736 0.5577608508429629 23.019197990303095 MQGSLEAHVNGFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MQGSLEAHVNGFR 13 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 34766300.0 12080000.0 8233300.0 14453000.0 False True 15836996.982886396 7004923.733152045 12957542.202965615 1.0 0.44231388947801337 0.8181817687385843 23.9167954612054 -10.083033260272584 5.672936409616594 1.0000023228262667 0.6302478291082474 0.5633754539354616 0.15344741914863586 4.508060195537094e-06 7.286302636135941e-07 0.14857575886545363 0.049524941573397846 8.259746902071261e-11 10.083033260272584 -0.3697544937180193 MQGSLEAHVNGFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQGSLEAHVNGFR 13 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 13561300.0 3662600.0 2339400.0 7559300.0 False True 3546332.7678058785 3273534.619809835 5579292.555861012 1.0 0.9230759869822301 1.5732569166973378 21.75789648625409 -6.877379891207212 1.094253439037161 0.9537862358814554 1.6170905268512197 0.9715122773819356 0.04895924542745501 0.12997888109459807 0.28649583282258717 0.03454195968825975 0.08300644952332843 1.3262338512294144e-07 6.877379891207212 0.6633042909697643 MQGSLEAHVNGFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MQGSLEAHVNGFR 13 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 54973600.0 8649600.0 27518000.0 18806000.0 False True 13122075.570462665 22607197.900884666 15088985.857037397 1.0 1.7228370450611243 1.149893229620029 23.645492598983218 -10.165094701159491 4.256008750035004 0.9998849433054525 1.436365137275902 0.4361174197189107 0.23390333332905264 81933146.25858584 22.930372436824452 97984.3761895251 0.08007133244093889 6.837625314908544e-11 10.165094701159491 0.43648019397044957 MQGSLEAHVNGFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MQGSLEAHVNGFR 13 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 31977900.0 12080000.0 9031900.0 10866000.0 False True 16546302.449725218 8632840.793500759 8299674.592294611 1.0 0.5217383653980121 0.5016029785211887 23.98000552272829 MQGSLEAHVNGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MQGSLEAHVNGFR 13 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 13896800.0 3662600.0 5492900.0 4741300.0 False True 3045614.1806912827 5463308.657444712 5732683.908705691 1.0 1.7938282176650062 1.8822751565349314 21.538301761688366 -11.129997110619971 0.39047575998702294 1.2640353735575954e-23 1.890339808853945 0.9995359022315549 0.00854625138782982 3.070759881921768 0.1934914386324992 2.729042287732895 0.023197456800563322 7.413151732865188e-12 11.129997110619971 1.890339808853945 MQGSLEAHVNGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MQGSLEAHVNGFR 13 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 41424600.0 8649600.0 20912000.0 11863000.0 False True 11197077.709106062 19748228.816874627 9704055.724659072 1.0 1.7636948970010553 0.8666596746727243 23.416618921075667 -6.6811959033950155 1.897743247596318 1.482677954314568 0.8700487485258835 0.3295932011698439 0.32358728642995194 0.43585205450318254 3.0358959366274085 0.13677221974691528 0.36016196322500266 2.083550814158772e-07 6.6811959033950155 -0.6126292057886845 MQHLIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQHLIAR 7 0 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 8371500.0 3143600.0 1452000.0 3775900.0 False True 3043808.138719643 2031791.1720799722 2786878.515428092 1.0 0.667516176934408 0.9155894157640215 21.537445993198073 -10.292864351097467 5.4533153882918715 1.0000290243403167 0.7915527963492072 0.4849059893720845 0.10127547566205002 3.5742843927112455e-05 4.634768981747647e-06 0.09807319875347037 0.03268651921819234 5.094899819084926e-11 10.292864351097467 -0.20847622799110954 MQIFVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MQIFVK 6 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 16835400.0 6308500.0 5221300.0 5305600.0 False True 8270504.591600892 4442302.392467994 4756627.4069089 1.0 0.5371259205852292 0.5751314631684614 22.97954392164608 -10.686562824801658 5.782341545564443 1.0068368533110856 0.5561286918769226 0.9945316079680669 0.015515697787756135 0.0013771546641036174 7.464985027056042e-05 0.015128872687520663 0.005007669928063893 2.0579611654742422e-11 10.686562824801658 -0.45070816143416303 MQIFVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQIFVK 6 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 5976710.0 2313400.0 1418610.0 2244700.0 False True 2239962.383291137 1985068.37095342 1656745.7304434532 1.0 0.8862061192459822 0.7396310504148852 21.09504307397535 -6.967664614820944 0.30891903313158164 1.0228712997318479 0.598313952602799 0.9999580073375227 0.0006906045683604016 0.07706800977727586 0.01172874860887193 0.002330529664076029 0.013026775983427486 1.0772968380984438e-07 6.967664614820944 -0.4245573471290489 MQIFVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MQIFVK 6 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 14200600.0 6308500.0 4159500.0 3732600.0 False True 8640922.930802274 3975719.5363728986 2851036.755310039 1.0 0.46010357553365766 0.32994586089258543 23.04275398316897 -13.999999999999963 0.1998287281873649 3.999257182409481 0.2452727176461924 0.9994869230194804 0.006571023025334578 12.527514835725107 0.14174417718008225 14.684483641817836 0.08298357964349734 1.0000000000000858e-14 13.999999999999963 -3.7539844647632883 MQIFVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MQIFVK 6 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3;A0A2R8Y422 P62979;A0A2R8Y422 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 6602810.0 2313400.0 1684110.0 2605300.0 False True 1923694.6009968908 1675037.36516034 3150056.1844538352 1.0 0.8707397547886798 1.6375032621193735 20.875448349409627 -6.863539689388566 1.1678069316174533 0.9291013119784152 1.677208506265064 0.9577946666223213 0.06885692624254214 0.1431949605187513 0.3691033336619954 0.04591940972542413 0.10764736198560483 1.3691792558533886e-07 6.863539689388566 0.7481071942866487 MQIFVK(ub)TLTGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MQIFVKTLTGK 11 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 4077927660.0 996274110.0 1103259250.0 1978394300.0 True False 1306125006.142206 938657270.3708739 1773689035.934174 1.0 0.7186580656190855 1.357978009450239 30.282645834416495 -6.787076068848306 1.5078663530567007 0.8421569691922689 1.3642518699191988 0.7917415108179476 0.11939374423496944 0.239744282874696 1.076869566575783 0.062333524067262926 0.14626296293755214 1.632765935735649e-07 6.787076068848306 0.5220949007269299 MQIFVK(ub)TLTGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MQIFVKTLTGK 11 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 4917410600.0 1388550700.0 1337361700.0 2191498200.0 True False 1344471918.082726 1871377201.059134 1617479077.8832426 1.0 1.391905011841227 1.203059027212585 30.324392476013045 -10.156198885117446 4.308334912252393 0.9999327586329159 1.29748201954646 0.7679062125372906 0.07709605045375151 53964121.63523206 4.928629363645155 36873.15829834753 0.026392028694917184 6.979127218177221e-11 10.156198885117446 0.29754926091354417 MQIFVK(ub)TLTGK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MQIFVKTLTGK 11 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 12764892300.0 2865880200.0 5473784300.0 4425227800.0 True False 4347749787.307219 4496944724.793051 3550579585.6837482 1.0 1.0343154378205919 0.8166476359907551 32.01762176974292 -6.8665780808543415 1.1519750550732717 1.0190604617486319 0.8046986197235649 0.9611507272623135 0.018833879715656233 0.140181877975736 0.3498226114992778 0.012712393160635872 0.02993231905868622 1.3596336957427698e-07 6.8665780808543415 -0.21436184202506692 MQIFVK(ub)TLTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MQIFVKTLTGK 11 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 4502219800.0 996274110.0 1132443790.0 2373501900.0 True False 1364623571.762486 1082408678.8669715 1812929635.0260463 1.0 0.7931921309764431 1.3285199468484548 30.345855895939387 -6.801979246632598 1.4479926789367463 0.886180726961601 1.3362611929096848 0.8378423139161035 0.08876110759636334 0.21794378821332927 0.9019596805534954 0.048221320642399715 0.11200375502828806 1.577686659855004e-07 6.801979246632598 0.4500804659480838 MQIFVK(ub)TLTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MQIFVKTLTGK 11 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 5486733700.0 1388550700.0 1335396100.0 2762786900.0 True False 1154641430.2759812 1328202056.153928 3340472867.106681 1.0 1.1503156056304533 2.893082457909244 30.10479775144732 -6.923896278695327 0.7952956161157918 0.9666743203075628 3.200949685873428 0.9951966019666187 0.059546263779091786 0.0959330045192534 0.09412958350270113 0.052394009539617654 0.1633005468570833 1.1915265429132187e-07 6.923896278695327 2.234275365565865 up MQIFVK(ub)TLTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MQIFVKTLTGK 11 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 11442260900.0 2865880200.0 5494726000.0 3081654700.0 True False 3709938413.844384 5188939667.847661 2520825165.0474167 1.0 1.3986592468716152 0.6794789788532469 31.78874809183537 -6.756238559059519 1.6266609112505024 1.2326417902407976 0.6773311054361211 0.6754284609056074 0.16759849895313994 0.2892749586520308 1.5076801490357084 0.08132911648675596 0.19617700352112158 1.7529173553909425e-07 6.756238559059519 -0.5553106848046765 MQIFVK(ub)TLTGK(ub)TITLEVEPSDTIENVK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MQIFVKTLTGKTITLEVEPSDTIENVK 27 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 1656535800.0 171313800.0 865186000.0 620036000.0 True False 259895559.31639865 710786798.5709274 497485612.82856655 1.0 2.734893972180612 1.9141751176399444 27.953356742632206 -10.39403815290272 6.248152265573514 0.9997832688169611 2.3245345449102786 0.7764250890856231 0.33505706931768797 0.0010117202865108242 9.811935391616366e-05 0.3244675119027019 0.10813920412470573 4.0360993415425434e-11 10.39403815290272 1.3247512760933176 MQIFVK(ub)TLTGK(ub)TITLEVEPSDTIENVK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MQIFVKTLTGKTITLEVEPSDTIENVK 27 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 680212400.0 171313800.0 309021600.0 199877000.0 True False 221769091.19985315 291824276.30818206 163501436.91120982 1.0 1.3158924660298887 0.7372598049016043 27.724483064724655 -6.758465025061371 1.618278957553217 1.1838368995286883 0.7353065666959728 0.6846696492847784 0.1328373209990553 0.285497996713627 1.473235178332018 0.06477768097794091 0.1559059227207245 1.7439537972448427e-07 6.758465025061371 -0.4485303328327155 MQIFVKTLTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQIFVKTLTGK 11 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 9767600.0 2629700.0 2608000.0 4529900.0 False True 2546221.612925005 3649388.00054033 3343383.2959129536 1.0 1.4332562342631474 1.313076316272486 21.279926560422805 -9.957694876958927 4.924426000459161 0.9999974550921428 1.3731662752042095 0.9278250649023304 0.04906324610277429 33671067.08233824 2.8144555077717164 1049.4673982905608 0.016795654141523276 1.1023134918868158e-10 9.957694876958927 0.37316882011206676 MQIFVKTLTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MQIFVKTLTGK 11 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 11711600.0 2629700.0 2398000.0 6683900.0 False True 2186712.0654627504 2385081.498034267 8081472.587138139 1.0 1.090715844900018 3.695718661262311 21.06033183585708 -6.9142891084892115 0.8660206352485565 0.9298662815606445 4.065179672760583 0.992441772202178 0.10866743946358313 0.10164994177923725 0.12389001196975598 0.09089871597812091 0.2590423017013897 1.2181783913698911e-07 6.9142891084892115 3.1353133911999382 up MQIMTHLPGAISDMIYIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQIMTHLPGAISDMIYIR 18 0 Q02338;E9PCG9 Q02338 BDH1 D-beta-hydroxybutyrate dehydrogenase, mitochondrial 0 7289900.0 2529800.0 1572000.0 3188100.0 False True 2449492.883742509 2199707.7978717024 2353040.96905011 1.0 0.8980257964705056 0.9606237212067206 21.224051669638833 -10.200832509233 4.618397518275938 1.0000144010372594 0.9293247588382298 0.6295783597630251 0.025555495762122106 3.790172508159966e-06 6.558803790614136e-07 0.024749043479704438 0.008248000790618762 6.297490061299142e-11 10.200832509233 -0.07068964219902951 MQIMTHLPGAISDMIYIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MQIMTHLPGAISDMIYIR 18 0 Q02338;E9PCG9 Q02338 BDH1 D-beta-hydroxybutyrate dehydrogenase, mitochondrial 0 26098600.0 7515700.0 9315000.0 9267900.0 False True 11401866.37126876 7652665.471572814 7436095.502735118 1.0 0.6711765620106326 0.6521823060015091 23.44276666265293 -13.999999999999998 0.405947507021327 6.759222275082013 0.6512210758988565 0.99984600634717 0.0019814560372811317 27.66860354843997 0.21070135045078364 140.6654160093679 0.004781912703090457 1.0000000000000041e-14 13.999999999999998 -6.108001199183156 MQIMTHLPGAISDMIYIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MQIMTHLPGAISDMIYIR 18 0 Q02338;E9PCG9 Q02338 BDH1 D-beta-hydroxybutyrate dehydrogenase, mitochondrial 0 5561700.0 2529800.0 1307300.0 1724600.0 False True 2103640.78914236 1300257.3154212674 2085205.8863505453 1.0 0.6180985471152485 0.9912366679297322 21.00445694507311 -10.801212116097876 10.037989867313128 1.0019739834289825 0.8046676078236706 0.26760463081207897 0.15233299992941135 0.006783473931081464 0.00013433667152039808 0.14867755974182728 0.04916526431703548 1.580475922004519e-11 10.801212116097876 -0.19730637560531183 MQIMTHLPGAISDMIYIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MQIMTHLPGAISDMIYIR 18 0 Q02338;E9PCG9 Q02338 BDH1 D-beta-hydroxybutyrate dehydrogenase, mitochondrial 0 18132900.0 7515700.0 5399900.0 5217300.0 False True 9729221.8065955 5099390.818106407 4267804.934018689 1.0 0.5241314176483775 0.43865840648483495 23.213892984745378 -13.999999999999998 0.24149047029959017 4.172696454335344 0.4013976114258505 0.999527457566983 0.005368216943864341 13.676507376876646 0.15552725262581044 20.943303732511602 0.04140270800892692 1.0000000000000041e-14 13.999999999999998 -3.771298842909493 MQK(ub)EITALAPSTMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MQKEITALAPSTMK 14 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 97905400.0 18966100.0 41444800.0 37494500.0 True False 24864740.76797366 35261397.39056512 33614928.812640525 1.0 1.4181284944656485 1.3519114929176057 24.567598054342422 -10.106868221708135 4.6258054726246955 0.9999715536333766 1.3850199936998828 0.97829774835025 0.02703297770984622 7.931296704384937e-06 1.5313283761487016e-06 0.026176499539284276 0.008724856035069242 7.818650104699563e-11 10.106868221708135 0.3850484400665062 MQK(ub)EITALAPSTMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MQKEITALAPSTMK 14 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 163950700.0 30789500.0 32184200.0 100977000.0 True False 29812104.175820187 45035518.898385756 74528094.45493327 1.0 1.5106454288762643 2.4999273454632918 24.829394870365416 -6.960662821400978 0.4259892108003424 0.958991045021768 3.0892690671563714 0.999793998163046 0.008936724032341518 0.07946519080984399 0.020262687066714455 0.01285370249466525 0.0822204319950787 1.0948060245456968e-07 6.960662821400978 2.130278022134603 MQK(ub)EITALAPSTMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MQKEITALAPSTMK 14 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 417978800.0 30478800.0 52977000.0 334523000.0 True False 46238567.89874874 43522840.43880975 268404382.42336056 1.0 0.9412670507900294 5.804772825384668 25.46259337958109 -6.904166287612528 0.9345397170184349 0.8202518683269117 6.3607933197034745 0.9885278640915756 0.24409511299195666 0.10840361943538006 0.16062362390255538 0.19425028500355238 0.5168423744597196 1.2469059932757495e-07 6.904166287612528 5.540541451376563 up MQK(ub)EITALAPSTMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MQKEITALAPSTMK 14 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 130318700.0 23410200.0 39342400.0 67566100.0 True False 32065583.576867368 37604122.68008108 51608378.747509465 1.0 1.1727253486572844 1.6094632621855847 24.93452232792213 -6.955218104772135 0.4982768411584254 0.9911213349421083 1.8098490485890046 0.9995497015982313 0.00544247843274244 0.0814556259908657 0.027796014554691828 0.0064034969536772976 0.036025010734879875 1.1086179221983204e-07 6.955218104772135 0.8187277136468963 MQK(ub)EITALAPSTMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MQKEITALAPSTMK 14 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 120084800.0 30789500.0 44025400.0 45269900.0 True False 25602833.456122473 43788226.4318423 54735626.78563181 1.0 1.7102882970701472 2.1378737974231026 24.609800145799692 -9.010052334305584 0.14257732125463496 3.343649853792142e-16 2.9255096313294864 0.9998650853996518 0.005450925877483876 0.48741743615675776 0.04683688353475448 0.5490467376286812 0.34403612673119377 9.771194668692876e-10 9.010052334305584 2.925509631329486 MQK(ub)EITALAPSTMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MQKEITALAPSTMK 14 1 P60709;P63267-2;A0A2R8YFE2;P63261;P68133;P68032;P63267;P62736;A6NL76 P60709;P63261;P68133 ACTB;ACTG2;ACTG1;ACTA1;ACTC1;ACTA2 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle 1 286716100.0 40641800.0 43318800.0 202755500.0 True False 52611611.26964783 40908070.69971444 165856079.44711375 1.0 0.777548334150996 3.1524615088684387 25.648877898567346 -6.8839686215960425 1.0574573568788492 0.8533391135991388 3.3340947268839973 0.9767465869345092 0.1633129409811672 0.12417101749026463 0.2515560305008688 0.1185142770467588 0.28970763317692955 1.3062652642755454e-07 6.8839686215960425 2.4807556132848587 up MQLLEIITTEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MQLLEIITTEK 11 0 H0YFD6;P40939;A0A2R8Y4F5 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 7104500.0 1037800.0 4661900.0 1404800.0 False True 1360565.850069497 3966362.6919438723 1259444.7717931268 1.0 2.9152302269980335 0.9256771891847756 20.375775352644347 -6.654810758847759 1.991197122519582 2.2380190249843337 0.9339994252704066 0.21386565375049071 0.8164788621113097 0.4968416240374572 3.7811155933964584 0.3319143165515071 0.9047399408515103 2.214059262162047e-07 6.654810758847759 -1.3040195997139272 MQLLEIITTEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQLLEIITTEK 11 0 H0YFD6;P40939;A0A2R8Y4F5 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 5804700.0 2062600.0 1448700.0 2293400.0 False True 1997123.8920101586 2027173.4648706964 1692689.7394747722 1.0 1.015046424000412 0.8475637121195494 20.929492402779324 -6.884969270679973 1.0516567503546128 1.010113908963328 0.8345006696422003 0.977479203443395 0.01135355408356639 0.12332105412830767 0.2464378074044684 0.008275282298448636 0.020290589655351965 1.3032589897223704e-07 6.884969270679973 -0.1756132393211277 MQLLEIITTEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MQLLEIITTEK 11 0 H0YFD6;P40939;A0A2R8Y4F5 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 8145500.0 1037800.0 4036200.0 3071500.0 False True 1421502.7054904678 3857867.338071478 2346074.9595281524 1.0 2.713935979981396 1.6504189196873003 20.438985414167238 -10.241903887524899 4.5193137076669565 0.9995567910829821 2.1821774498448248 0.6222796179977981 0.4341790217798548 0.0019395676826408624 0.0003253521036711878 0.42054044321530654 0.14013067671382484 5.7292280887227276e-11 10.241903887524899 1.1826206587618426 MQPASAK(ub)WYDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQPASAKWYDR 11 1 Q15185-4;Q15185;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 5322700.0 2567800.0 2490700.0 264200.0 True False 2486286.5945426566 3485249.4988289145 194998.09416989394 1.0 1.4017891205619493 0.07842945161587984 21.24556117492384 -6.825235649449953 1.3489049871842786 1.2154952570811435 0.04612226488769286 0.8960427870564561 0.1786152321944296 0.18675943509804174 0.6662175238498128 0.10401069210265199 0.2394800072775301 1.495424014491905e-07 6.825235649449953 -1.1693729921934506 down MQPASAK(ub)WYDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MQPASAKWYDR 11 1 Q15185-4;Q15185;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 7618500.0 1935000.0 2412200.0 3271300.0 True False 2650421.7914087996 2305621.027921315 2498686.3145383187 1.0 0.8699072107673058 0.9427504416986295 21.337790539547623 -10.232727164558595 5.002885628947061 1.0000100525969222 0.9063288263766648 0.6879695508691812 0.02973812456970799 4.506213794717347e-06 6.911051901357341e-07 0.028797990340570092 0.009597938423265858 5.85157580382949e-11 10.232727164558595 -0.09368122622025743 MQPASAK(ub)WYDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MQPASAKWYDR 11 1 Q15185-4;Q15185;Q15185-3;B4DDC6;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 8815900.0 2567800.0 3891200.0 2356900.0 True False 2135239.472827793 3870237.3332572696 2849716.8929256652 1.0 1.812554227527342 1.3346123136023043 21.025966450358116 -10.113321360370767 4.889835138189192 0.9999735224763733 1.5735832705679658 0.6575758410441549 0.19511896931178144 5.6324980041452057e-05 1.0213056578183724e-05 0.18893183415398238 0.06297437655459254 7.703332426407102e-11 10.113321360370767 0.5736097480915925 MQQENMK(ub)PQEQLTLEPYER ddPTM_RPMI8226_Bortezomib_1h_R1 1 MQQENMKPQEQLTLEPYER 19 1 P22087;M0R299;M0QXL5 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 16779200.0 3697000.0 6238700.0 6843500.0 True False 4846802.801798929 5307910.278262135 6135400.267487376 1.0 1.095136421950582 1.2658654619103078 22.208601955180203 -6.962107862989292 0.4046341120080076 0.99108130309247 1.376201473918967 0.9998405572877453 0.0013888615033708317 0.07895659419490794 0.018411232108918242 0.0021964518512217236 0.014280364840612646 1.0911692959359173e-07 6.962107862989292 0.38512017082649697 MQQENMK(ub)PQEQLTLEPYER ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQQENMKPQEQLTLEPYER 19 1 P22087;M0R299;M0QXL5 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 16314500.0 3831400.0 4848000.0 7635100.0 True False 3709774.3042023247 6783831.681986018 5635238.2619097475 1.0 1.8286373039733146 1.519024555085821 21.822899987945828 -10.15139895422872 4.680283871978706 0.9999280811907464 1.6738309295364027 0.8633026417767464 0.12639887546259854 88432293.86783834 9.28212192187741 68541.8406725188 0.043269697080324535 7.056690104813128e-11 10.15139895422872 0.6739028483456563 MQQENMK(ub)PQEQLTLEPYER ddPTM_RPMI8226_Bortezomib_8h_R1 1 MQQENMKPQEQLTLEPYER 19 1 P22087;M0R299;M0QXL5 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 45934000.0 5372000.0 14478000.0 26084000.0 True False 8149716.7458062 11894287.7828697 20928485.96697665 1.0 1.4594725379861129 2.5680016397804666 22.958318486763325 -6.956219624808884 0.48579092710259125 0.9747893076656003 3.099357369706373 0.999603281801707 0.013109104980895804 0.08108024037068519 0.02633917205213903 0.01581812962317469 0.09143103916810291 1.1060643004848263e-07 6.956219624808884 2.1245680620407725 MQQENMK(ub)PQEQLTLEPYER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MQQENMKPQEQLTLEPYER 19 1 P22087;M0R299;M0QXL5 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 11538700.0 3697000.0 3400700.0 4441000.0 True False 5063880.807668394 3250445.8293889435 3392127.2652660017 1.0 0.6418882973048439 0.6698671224901653 22.271812016703095 -9.93845102018275 5.149881155133395 1.0000011745234894 0.6558777098933101 0.9950665939436725 0.011422307565711378 3312136.2736162855 6391895.734422871 27.78261205239739 0.003910159621119757 1.1522560041573045e-10 9.93845102018275 -0.3441234646301793 MQQENMK(ub)PQEQLTLEPYER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MQQENMKPQEQLTLEPYER 19 1 P22087;M0R299;M0QXL5 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 15368600.0 3831400.0 5591500.0 5945700.0 True False 3185978.859799206 5561377.479674148 7188918.38018929 1.0 1.7455789019342867 2.25642375437556 21.603305263380104 -8.01860089260528 0.13179748571812483 1.4236812317803298e-21 3.474067361402467 0.9999683442367278 0.0029026717616305545 0.10634556902998095 0.022787090700267618 0.2542714895812323 0.29848866479771013 9.580741166036371e-09 8.01860089260528 3.474067361402467 MQQENMK(ub)PQEQLTLEPYER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MQQENMKPQEQLTLEPYER 19 1 P22087;M0R299;M0QXL5 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 48425500.0 5372000.0 8466500.0 34587000.0 True False 6954159.8979510795 7995331.832348354 28292520.89258901 1.0 1.1497192974674104 4.068431170373994 22.729444808855774 -6.917539691820764 0.8427764815455319 0.9297147571955502 4.513452147171711 0.9934696812979972 0.1141451756254518 0.09964106415183796 0.11327642151290543 0.09708738681691122 0.28431966564066913 1.209094674142828e-07 6.917539691820764 3.583737389976161 up MQQHFEFEYQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MQQHFEFEYQTK 12 0 P08243-2;P08243;P08243-3;F8WEJ5;C9J057;C9JT45;C9JM09 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 8634600.0 3009500.0 2422600.0 3202500.0 False True 3945483.6440394563 2061157.523220838 2871136.0205491814 1.0 0.5224093442472336 0.7277019193544702 21.911770728394288 -10.262837319016382 5.613140832013281 1.0000273003924547 0.6250556318008434 0.8164329928168813 0.08381034283248393 2.863554039247447e-05 3.760586537659258e-06 0.08115491374433079 0.02704967183584095 5.459623330801481e-11 10.262837319016382 -0.37497166859161124 MQQHFEFEYQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MQQHFEFEYQTK 12 0 P08243-2;P08243;P08243-3;F8WEJ5;C9J057;C9JT45;C9JM09 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 10352600.0 3009500.0 3187700.0 4155400.0 False True 4122193.478679476 3046856.87368575 3173980.1031493703 1.0 0.7391348536754746 0.7699735879855254 21.97498078991718 -9.87553550384084 6.5076436923040095 1.0000000118124521 0.754554220954744 0.9882987687196437 0.012589860562209974 2.161244638944812e-09 3.768224053036679e-10 0.012190080707862407 0.0040633600240335185 1.3318781560045518e-10 9.87553550384084 -0.24544579085770812 MQQQLDEYQELLDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MQQQLDEYQELLDIK 15 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 10497120.0 726820.0 5049200.0 4721100.0 False True 952868.0585348931 4295879.041627443 4232605.859988987 1.0 4.508367137662987 4.441964259455753 19.861916935712067 -10.13162451922 4.563127503543654 0.9996213625334803 4.475165698638025 0.9997262430468694 0.02710886177637821 4732298.822586452 14.266509272176787 18837.281995483358 0.009280084399716448 7.385424806148258e-11 10.13162451922 3.475544336104545 MQQQLDEYQELLDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQQQLDEYQELLDIK 15 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 21404400.0 6969800.0 4472500.0 9962100.0 False True 6748547.514075633 6258392.57377938 7352727.153406134 1.0 0.9273688242879045 1.0895273594903714 22.686145594490625 -6.784946758350464 1.516499064268752 0.9591377238739263 1.0910188643218799 0.7845126062963338 0.030786444178321933 0.2429756996394627 1.1039236258261111 0.015984375619591814 0.0375651024417989 1.6407909110535145e-07 6.784946758350464 0.13188114044795363 MQQQLDEYQELLDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MQQQLDEYQELLDIK 15 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 17255920.0 726820.0 6128100.0 10401000.0 False True 995544.9955719621 5857340.279083249 7944498.015319007 1.0 5.883551527189468 7.980049169706008 19.92512699723496 -8.819747224311795 0.3853805991712907 7.508395897454995e-19 8.45585150258825 0.997474742246793 0.14695336945275317 0.35020904101936867 0.1323010385828463 1.1221998747776027 0.5424196420818871 1.5144424543116386e-09 8.819747224311795 8.45585150258825 MQSALK(ub)TFAVDETSVSGYIYHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQSALKTFAVDETSVSGYIYHK 22 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 1 34205000.0 13059000.0 12167500.0 8978500.0 True False 12644449.19313521 17026046.202674262 6626761.500773618 1.0 1.3465233591921002 0.5240846318850606 23.59200085711305 -6.792247422137994 1.4874031230416223 1.1931059694563861 0.5147951638367451 0.8085115837488287 0.14753104860156074 0.23201405325992835 1.013986492749077 0.07806312713516421 0.18246539125320543 1.6134391016994232e-07 6.792247422137994 -0.6783108056196411 MQSALK(ub)TFAVDETSVSGYIYHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MQSALKTFAVDETSVSGYIYHK 22 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 1 59725500.0 27504500.0 19779000.0 12442000.0 True False 41726337.348292455 16249282.915967664 9982833.246477677 1.0 0.38942509572153056 0.23924537548432104 25.314454953579645 -13.999999999999968 0.19698747006547132 4.355952757250784 0.13876486589914272 0.9994870573674506 0.007451016270263017 12.47292158231952 0.1407422406383394 16.108056134694195 0.09781986887778758 1.0000000000000737e-14 13.999999999999968 -4.217187891351641 MQSALK(ub)TFAVDETSVSGYIYHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MQSALKTFAVDETSVSGYIYHK 22 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 1 33829700.0 13059000.0 17950100.0 2820600.0 True False 10859137.111791488 17853399.248484123 3410374.4190191072 1.0 1.6440900473664575 0.3140557471473422 23.372406132547326 -6.775020637631111 1.5550197318640424 1.3670752176247476 0.30508202253016337 0.7493940856925776 0.27186577629104297 0.25842734271200435 1.2338439602425433 0.13774419835088686 0.32643106830146296 1.678724243416018e-07 6.775020637631111 -1.0619931950945842 MQSALK(ub)TFAVDETSVSGYIYHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MQSALKTFAVDETSVSGYIYHK 22 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 1 59770200.0 27504500.0 25174900.0 7090800.0 True False 35605117.44474979 23773894.684484325 5800347.157752041 1.0 0.6677100481798844 0.16290768221036553 25.085581275672094 -7.375050368948083 0.47464346257105255 1.0163786045274847 3.081247781760028e-23 0.9984468962422034 0.013562836735585417 0.10827896725238043 0.05103135695154139 0.016169878147065966 0.06050425758455376 4.2164759841481394e-08 7.375050368948083 -1.0163786045274847 down MQTNQTPPTYNK(ub)TNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MQTNQTPPTYNKTNK 15 1 Q93050-1;Q93050;Q93050-3;B7Z641;B7Z2A9;F5H1T6 Q93050-1 ATP6V0A1 V-type proton ATPase 116 kDa subunit a isoform 1;V-type proton ATPase subunit a 1 7064350.0 426660.0 837990.0 5799700.0 True False 559355.3917813177 712965.1584594366 5199602.678650778 1.0 1.2746192652026376 9.295704940095732 19.09340567887304 -6.914170292278528 0.8668599416652257 0.7831950947338371 10.430341946419908 0.9924023318150889 0.33536914314618405 0.10172429154656445 0.12428876025356819 0.2803636605119074 0.7982227357962717 1.2185117116109998e-07 6.914170292278528 9.64714685168607 up MQTNQTPPTYNK(ub)TNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MQTNQTPPTYNKTNK 15 1 Q93050-1;Q93050;Q93050-3;B7Z641;B7Z2A9;F5H1T6 Q93050-1 ATP6V0A1 V-type proton ATPase 116 kDa subunit a isoform 1;V-type proton ATPase subunit a 1 45006800.0 1226800.0 20691000.0 23089000.0 True False 1588116.7838433348 19539527.66114922 18887038.913146198 1.0 12.303583628064448 11.89272672217371 20.59888557580799 -10.226734623005845 6.8090160503194745 0.9999397337138324 12.09815517511908 0.9989731791257269 0.1677316294551687 0.00015345439412038658 1.74269079719992e-05 0.162406195588147 0.05413515062600796 5.932877441615656e-11 10.226734623005845 11.098215441405248 MQVTITLTSPIIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MQVTITLTSPIIR 13 0 Q96KR1;H0Y8W1 Q96KR1 ZFR Zinc finger RNA-binding protein 0 61544000.0 0.0 31756000.0 29788000.0 False True 0.0 26088893.689239547 23900388.743455775 0.0 MQVTITLTSPIIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MQVTITLTSPIIR 13 0 Q96KR1;H0Y8W1 Q96KR1 ZFR Zinc finger RNA-binding protein 0 25070100.0 0.0 9560100.0 15510000.0 False True 0.0 9028072.030996697 12687339.146039126 0.0 MQYGLFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MQYGLFLK 8 0 A0A5F9ZHU7;P49643;A0A096LP51 A0A5F9ZHU7 PRIM2 DNA primase large subunit 0 8054000.0 2350600.0 2360500.0 3342900.0 False True 3081659.363242784 2008322.601156934 2997008.7753610793 1.0 0.651701685498298 0.9725308420225173 21.555275969100233 -10.43188122484465 8.432485962601413 1.0000030425351427 0.8121162643983192 0.313783750944274 0.13097795468197565 7.492114717485434e-06 5.046970699170868e-07 0.12682091304152263 0.04227295310030014 3.699293378851875e-11 10.43188122484465 -0.18788677813682353 MQYGLFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MQYGLFLK 8 0 A0A5F9ZHU7;P49643;A0A096LP51 A0A5F9ZHU7 PRIM2 DNA primase large subunit 0 6244640.0 2222600.0 629340.0 3392700.0 False True 2152044.77958973 880638.7439647431 2504050.091181672 1.0 0.4092102322018735 1.1635678378676904 21.037276667023498 -6.697818236509482 1.8389394107095995 0.6323581310810252 1.161214002839046 0.40713301890349696 0.24948076123006518 0.4000590965441162 2.628710852284349 0.10830174232714349 0.2792461385640226 2.005311126411985e-07 6.697818236509482 0.5288558717580208 MQYGLFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MQYGLFLK 8 0 A0A5F9ZHU7;P49643;A0A096LP51 A0A5F9ZHU7 PRIM2 DNA primase large subunit 0 5416500.0 2222600.0 1346500.0 1847400.0 False True 1848190.377874855 1339246.137240675 2233682.798587499 1.0 0.7246256409908429 1.2085783073689105 20.817681942457774 -6.752355299066999 1.6410222700313921 0.8385342409367301 1.209720694970291 0.659047166730635 0.11573079630764571 0.29597483200849245 1.5688643476310644 0.05569265697610582 0.13487969283638893 1.7686614131682444e-07 6.752355299066999 0.3711864540335609 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPSDK 40 1 F8VVB9;F8VS66;F8W0F6;P68363;P68363-2;Q71U36;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 184705000.0 36519000.0 55366000.0 92820000.0 False True 55401992.89651837 45485504.72346761 74474086.31554872 1.0 0.8210084573749342 1.344249230432086 25.72343453742123 -6.814377575455246 1.3960532437709128 0.9029423358647534 1.3543485889048048 0.8709453638025019 0.07800376800967651 0.2008949530060094 0.7708094654820056 0.04392384813590482 0.10141862344496455 1.5332833671921415e-07 6.814377575455246 0.45140625304005144 MREDYDSVEQDGDEPGPQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MREDYDSVEQDGDEPGPQR 19 1 Q9Y5S9;Q9Y5S9-2 Q9Y5S9 RBM8A RNA-binding protein 8A 0 11880100.0 1999700.0 1242400.0 8638000.0 False True 1936220.618080438 1738496.7990304083 6375448.665554669 1.0 0.8978815651462009 3.292728424654038 20.884811915778002 -6.8969405975631455 0.9804181931888265 0.8919017486047816 3.529047090533973 0.9849814084335008 0.1354988312357203 0.11369203071979146 0.19039742359204045 0.104222999942231 0.2672352899001631 1.267825266080813e-07 6.8969405975631455 2.6371453419291915 up MRPGVACSVSQAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MRPGVACSVSQAQK 14 1 P32969;E7ESE0;A0A2R8Y5Y7;H0Y9V9 P32969 RPL9 60S ribosomal protein L9 0 13959490.0 801190.0 6997100.0 6161200.0 False True 1050367.848734997 5953159.95448218 5523698.126403635 1.0 5.66769057302337 5.258822547792244 20.002463231127937 -10.251441755558323 4.460602124740197 0.9979577393747783 5.463256560455836 0.9937454078860499 0.16691967249711157 29483176.07197909 2182.1374371435386 619169.4153456403 0.057141043673241305 5.6047757953205496e-11 10.251441755558323 4.465298821081058 MRPGVACSVSQAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MRPGVACSVSQAQK 14 1 P32969;E7ESE0;A0A2R8Y5Y7;H0Y9V9 P32969 RPL9 60S ribosomal protein L9 0 12420090.0 801190.0 5630100.0 5988800.0 False True 1097411.5943456423 5381343.565749022 4574368.783207621 1.0 4.9036693192199925 4.168325546018308 20.06567329265083 -10.249987364567462 4.741741082307287 0.9990179214730981 4.535997432628163 0.9685836761226367 0.30020283834378697 0.003117238317689488 0.0004930616492362455 0.29071662071837895 0.09689004944475081 5.623576862760601e-11 10.249987364567462 3.5369795111550646 MRYVASYLLAALGGNSSPSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MRYVASYLLAALGGNSSPSAK 21 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 40737000.0 25780000.0 3193600.0 11763400.0 False True 33797829.65387513 2717127.328555296 10546236.210500635 1.0 0.0803935446856056 0.3120388592553145 25.010427270241973 -10.442076697088266 6.672845735887543 1.0001521258835313 0.1962162042066265 0.941361069113274 0.09456880366704747 0.00021406405541470234 1.7898129361512754e-05 0.091582677116532 0.030521950139436142 3.613460427252066e-11 10.442076697088266 -0.8039359216769049 MRYVASYLLAALGGNSSPSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MRYVASYLLAALGGNSSPSAK 21 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 23296100.0 7830100.0 6366800.0 9099200.0 False True 7581537.7614800455 8909096.442423383 6715846.549851235 1.0 1.1751041441339698 0.8858158807798627 22.85405906888876 -6.742869752782495 1.6765237558971224 1.1038403601834752 0.8855491533980546 0.6176203448475737 0.07356800584864046 0.3126456469636865 1.7265742249453162 0.03470180661266839 0.08487735141170775 1.8077161883915556e-07 6.742869752782495 -0.21829120678542058 MRYVASYLLAALGGNSSPSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MRYVASYLLAALGGNSSPSAK 21 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 144015920.0 30079900.0 86514120.0 27421900.0 False True 41201251.90873265 82691640.11446317 20945411.991758157 1.0 2.007017658046856 0.50836833885911 25.29618483887926 -6.725678322852708 1.7391488817013583 1.6089206251294361 0.5099642654348225 0.5390618837558294 0.42348863447219015 0.34439230165704227 2.0386626526626936 0.19313620169333495 0.48158761268460326 1.880709321747602e-07 6.725678322852708 -1.0989563596946135 MSASILLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MSASILLSK 9 0 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 0 7730300.0 2050400.0 2719300.0 2960600.0 False True 2688094.256101847 2313591.0397483823 2654265.512080532 1.0 0.860680772073613 0.9874153430652495 21.358152295397176 -10.364157074154697 6.366411380149023 1.0000067998799675 0.9240480575712487 0.32381241530202565 0.0517391719500067 4.99408286725025e-06 4.987738421038138e-07 0.05010072264246449 0.016698745942411476 4.3235742918522615e-11 10.364157074154697 -0.0759587423087188 MSASILLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSASILLSK 9 0 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 0 5958300.0 2050400.0 2211500.0 1696400.0 False True 2808488.289976543 2113788.617547463 1295745.258454683 1.0 0.7526428452956512 0.46136751329146736 21.421362356920067 -6.968967202503925 0.28176752038262404 1.0628190265389792 0.14229408868192986 0.9999731663953665 0.001140332600394868 0.07663931393615994 0.010224506675830282 0.005326008883711403 0.026676288781041137 1.0740705220377399e-07 6.968967202503925 -0.9205249378570494 down MSATFIGNSTAIQELFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MSATFIGNSTAIQELFK 17 0 P68371;Q13885;Q9BVA1 P68371;Q13885;Q9BVA1 TUBB4B;TUBB2A;TUBB2B Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 27195400.0 6849100.0 11728400.0 8617900.0 False True 8979236.426778747 9978568.436945133 7726202.376734044 1.0 1.1112936515610705 0.8604520484272156 23.098161336101597 -6.786073135493707 1.5117772093039712 1.0625205939909335 0.858057594728539 0.7884204722316249 0.04720382202677323 0.24125319172004517 1.0892581532477188 0.024581851500067243 0.05772617149533406 1.6365409035915616e-07 6.786073135493707 -0.20446299926239442 MSATFIGNSTAIQELFK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MSATFIGNSTAIQELFK 17 0 P68371;Q13885;Q9BVA1 P68371;Q13885;Q9BVA1 TUBB4B;TUBB2A;TUBB2B Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 225849900.0 116110900.0 16443200.0 93295800.0 False True 112425023.03539345 23009055.5101552 68858831.16599385 1.0 0.2046613368530201 0.6124866983066202 26.744387938707735 -10.729316725623047 9.757922788911891 1.0013508088842629 0.40857401760620216 0.7371246525911512 0.16649400662123925 0.0048993980311806224 0.00013590845286235863 0.16142655591354946 0.053735709573950595 1.865019059292208e-11 10.729316725623047 -0.5927767912780607 MSATFIGNSTAIQELFK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MSATFIGNSTAIQELFK 17 0 P68371;Q13885;Q9BVA1 P68371;Q13885;Q9BVA1 TUBB4B;TUBB2A;TUBB2B Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 994687700.0 232194000.0 430196700.0 332297000.0 False True 352255273.6551982 353424737.7428412 266618352.29905096 1.0 1.003319933511592 0.7568895975139547 28.3920460645529 -6.903846733940272 0.9366212752579661 1.0091925991860429 0.728902344480261 0.9883850279669154 0.012436311255756761 0.1086291429744246 0.16187803102599496 0.009881652659386743 0.026244114571358595 1.2478238037306032e-07 6.903846733940272 -0.28029025470578184 MSATFIGNSTAIQELFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSATFIGNSTAIQELFK 17 0 P68371;Q13885;Q9BVA1 P68371;Q13885;Q9BVA1 TUBB4B;TUBB2A;TUBB2B Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 27184780.0 6849100.0 6575380.0 13760300.0 False True 9381397.359967967 6284857.969726085 10510400.542274224 1.0 0.6699277014471908 1.1203448845610045 23.16137139762449 -6.710313767925489 1.7942828330539953 0.7971374968839862 1.1192859670857735 0.4664498462138119 0.13908460693887292 0.37447281414548195 2.350344026354525 0.06168410716465203 0.15663550246404195 1.9484363899639072e-07 6.710313767925489 0.3221484702017874 MSATFIGNSTAIQELFK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MSATFIGNSTAIQELFK 17 0 P68371;Q13885;Q9BVA1 P68371;Q13885;Q9BVA1 TUBB4B;TUBB2A;TUBB2B Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 236025000.0 116110900.0 51327000.0 68587100.0 False True 96551357.93502644 51050491.26338823 82928345.49908012 1.0 0.5287392363527638 0.8589039789050525 26.52479321414201 -10.162194255915761 5.727676451577195 1.0000048673693946 0.6938216076288946 0.5341553235471463 0.13478919171846493 8.37795633960437e-06 1.2254145513667974e-06 0.13051114820307586 0.04350302456452359 6.883443374030797e-11 10.162194255915761 -0.3061832597405001 MSATFIGNSTAIQELFK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MSATFIGNSTAIQELFK 17 0 P68371;Q13885;Q9BVA1 P68371;Q13885;Q9BVA1 TUBB4B;TUBB2A;TUBB2B Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 665129000.0 232194000.0 226389000.0 206546000.0 False True 300579710.2280069 213790253.13807532 168956747.34092808 1.0 0.7112597619310471 0.5621029683366343 28.16317238664535 -13.99999999990638 0.0840778131768721 2.521300927471315 0.1484386000230382 0.999869308646906 0.002078025569588584 12.21867691378562 0.08274556012823174 3.3967277816965087 0.3738810144977502 1.0000000002155665e-14 13.99999999990638 -2.372862327448277 MSAYAFFVQTCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MSAYAFFVQTCR 12 0 E9PES6;E7ES08;E7EQU1;O15347 E9PES6 HMGB3 High mobility group protein B3 0 6592100.0 1983400.0 3221200.0 1387500.0 False True 2600256.6072729244 2740609.516139254 1243934.8098398114 1.0 1.053976560803177 0.47838925064569493 21.31022257249042 -6.883933953863236 1.0575780622936768 1.0355718151792415 0.4343846689567906 0.9767240965887933 0.03959797078364039 0.1242040746751098 0.2516925469160555 0.028731888835277213 0.07023260736611345 1.306369541590934e-07 6.883933953863236 -0.6011871462224508 down MSAYAFFVQTCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MSAYAFFVQTCR 12 0 E9PES6;E7ES08;E7EQU1;O15347 E9PES6 HMGB3 High mobility group protein B3 0 31746800.0 8738100.0 8810700.0 14198000.0 False True 13256336.540679287 7238361.746686705 11391759.076795543 1.0 0.5460303247789902 0.8593444381740025 23.66017879827204 -10.137209297675827 5.461175658862344 1.0000057724709988 0.7026873814764234 0.5455825681473236 0.1279099511719732 8.989998493220863e-06 1.4203657421294425e-06 0.12385068170681203 0.04128275922523388 7.291060506227401e-11 10.137209297675827 -0.29731839099457535 MSAYAFFVQTCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSAYAFFVQTCR 12 0 E9PES6;E7ES08;E7EQU1;O15347 E9PES6 HMGB3 High mobility group protein B3 0 4356600.0 1983400.0 2373200.0 0.0 False True 2716716.579369623 2268344.176877067 0.0 1.0 0.834957976147591 0.0 21.373432634013312 -7.198882860480228 0.8934806167310543 0.9908311409493993 8.947973854710288e-20 0.9893569631511814 0.0451574840658784 0.09269675633833403 0.14073258566382627 0.038043068145583725 0.0667908524155116 6.325824508546312e-08 7.198882860480228 -0.9908311409493993 down MSAYAFFVQTCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MSAYAFFVQTCR 12 0 E9PES6;E7ES08;E7EQU1;O15347 E9PES6 HMGB3 High mobility group protein B3 0 36177100.0 8738100.0 12514000.0 14925000.0 False True 11311642.703701844 11817584.89930992 12208803.143432226 1.0 1.0447275615806448 1.079313010782844 23.431305120364488 -6.973996267893271 0.13139308764815885 0.947516247326319 1.1774203691549487 0.9999991522013745 2.933198428338993e-05 0.07502644190730229 0.0039492367398901015 0.002143074798229844 0.00469216577821769 1.0617046809116058e-07 6.973996267893271 0.22990412182862974 MSCTVNLLNFYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSCTVNLLNFYK 12 0 Q92608 Q92608 DOCK2 Dedicator of cytokinesis protein 2 0 3812700.0 994400.0 1468000.0 1350300.0 False True 1362056.5526495685 1403138.9059731725 1031386.9503014382 1.0 1.0301620026302782 0.7572276997567476 20.377355174680975 -6.8794817968332795 1.0826367202632807 1.0185708301417156 0.7380724701125692 0.9732671527502998 0.0199758864476768 0.12809234314413967 0.2750413820742648 0.014219414939724092 0.034342761193654515 1.319830630378012e-07 6.8794817968332795 -0.2804983600291464 MSDPAAFESRLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MSDPAAFESRLEK 13 1 E9PPX6;Q5TC12-3 E9PPX6 ATPAF1 0 59283200.0 14887000.0 6836200.0 37560000.0 False True 14414420.333731823 9565930.31031205 27721909.224152934 1.0 0.663636142753961 1.9232066626557065 23.781009485195206 -6.835665601197741 1.3024989885023823 0.8208517092989481 1.9611717708651923 0.9167184469168096 0.15367062475530946 0.17392496390757683 0.5750471730459912 0.0925767856462353 0.21308017791194228 1.459937953111311e-07 6.835665601197741 1.140320061566244 MSDPAAFESRLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSDPAAFESRLEK 13 1 E9PPX6;Q5TC12-3 E9PPX6 ATPAF1 0 53377400.0 1214400.0 25869000.0 26294000.0 False True 1663396.4979260184 24726022.042656705 20083898.741928473 1.0 14.86477942780689 12.074029713883483 20.665700669043954 -9.329749306583954 9.576566335863292 0.9999968240499277 13.469404571024421 0.9637927721943813 1.1393187998241598 0.0 0.0 1.1031406844339091 0.36771356147796963 4.68005216029071e-10 9.329749306583954 12.469407746974493 MSDPAAFESRLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MSDPAAFESRLEK 13 1 E9PPX6;Q5TC12-3 E9PPX6 ATPAF1 0 16381070.0 14887000.0 500640.0 993430.0 False True 12379200.105922343 497942.9529507403 1201151.6198986573 1.0 0.04022416219869642 0.09702982499846766 23.561414760629482 -10.771499322476746 2.874037749875941 1.2053008204366096 0.06862699197728057 0.9972178055495183 0.023190819945330652 25028007.760740824 21015598.75179045 36274375.75128126 0.009183437596753281 1.6923908846571263e-11 10.771499322476746 -1.136673828459329 MSFCVYSILGVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MSFCVYSILGVVK 13 0 Q9HAV4 Q9HAV4 XPO5 Exportin-5 0 15465500.0 5839900.0 4790000.0 4835600.0 False True 7559865.671638962 4523432.2892515985 3955570.417445957 1.0 0.5983482360303538 0.523232897151253 22.849929169301998 -13.999999999999998 0.2357649555038179 3.60503968565182 0.48865840130093435 0.9995181854828981 0.004594275560723332 13.477668294153588 0.1537028088603701 16.489497773101775 0.03764023260039708 1.0000000000000041e-14 13.999999999999998 -3.1163812843508856 MSFIAPNLSIIIGASTAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MSFIAPNLSIIIGASTAAK 19 0 Q8WWY3;E7EVX8;Q8WWY3-4;Q8WWY3-2;Q8WWY3-3;E7EU94;E7ESX0;E7EN72 Q8WWY3 PRPF31 U4/U6 small nuclear ribonucleoprotein Prp31 0 285046000.0 77908000.0 83168000.0 123970000.0 False True 118192131.83772705 68326020.60545015 99467275.16201867 1.0 0.578092801467182 0.8415727309038064 26.81655875623432 -10.408583654322628 6.066003382105726 1.0000750092488602 0.7098327661854943 0.6178995868804358 0.10756523076404143 0.00010914479901670792 1.0641173307160969e-05 0.10417639530248277 0.03471652894834079 3.903159921329431e-11 10.408583654322628 -0.2902422430633659 MSFIAPNLSIIIGASTAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MSFIAPNLSIIIGASTAAK 19 0 Q8WWY3;E7EVX8;Q8WWY3-4;Q8WWY3-2;Q8WWY3-3;E7EU94;E7ESX0;E7EN72 Q8WWY3 PRPF31 U4/U6 small nuclear ribonucleoprotein Prp31 0 209232000.0 103207000.0 48545000.0 57480000.0 False True 133603496.01411715 45843428.07551542 47019229.7946053 1.0 0.34313045274407633 0.351931133520915 26.993382518529426 -10.183159520265884 5.402023730759211 1.00002523296959 0.3475307931323747 0.9998635681947174 0.0035928628824911297 1.091903369425847e-06 1.6510221364040532e-07 0.003478908749520004 0.0011595915090292382 6.559043025070973e-11 10.183159520265884 -0.6524944398372152 MSFLFSAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MSFLFSAFK 9 0 E5RFR8;E5RJI3;E5RIU9;Q8WUX9-2;Q8WUX9 E5RFR8 CHMP7 Charged multivesicular body protein 7 0 4086660.0 803760.0 2097000.0 1185900.0 False True 1053737.1436229108 1784135.7740419798 1063194.4439560578 1.0 1.6931506921240773 1.0089750089862366 20.007083598646105 -10.29842980115315 5.852887682788848 0.9999725100911747 1.3510628505551583 0.2598368207406212 0.27931355301797417 0.00010020098457943614 1.2011005329376537e-05 0.27046532619193947 0.09014806160071893 5.0300256401985e-11 10.29842980115315 0.3510903404639836 MSFLFSAFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MSFLFSAFK 9 0 E5RFR8;E5RJI3;E5RIU9;Q8WUX9-2;Q8WUX9 E5RFR8 CHMP7 Charged multivesicular body protein 7 0 21927400.0 6159800.0 5307600.0 10460000.0 False True 9344866.941700878 4360417.311531922 8392576.415219136 1.0 0.46661095751656295 0.8980948008759541 23.15574269140965 -9.988864974088699 7.012088764633861 1.0000000258093085 0.6823528791962609 0.41948304628336264 0.1761525414142501 7.098765021863296e-08 1.0148582063387672e-08 0.17055898007150574 0.056852988274125056 1.0259708598847552e-10 9.988864974088699 -0.3176471466130476 MSFLFSAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSFLFSAFK 9 0 E5RFR8;E5RJI3;E5RIU9;Q8WUX9-2;Q8WUX9 E5RFR8 CHMP7 Charged multivesicular body protein 7 0 4282760.0 803760.0 1300700.0 2178300.0 False True 1100931.7927972793 1243230.773160291 1663830.403496722 1.0 1.1292532210387478 1.5112929015059267 20.070293660168996 -6.951784267755089 0.5388992002185139 0.9943343055610001 1.6638211906436 0.9993339705777124 0.005602085121351712 0.08277709066785105 0.03305765488750376 0.006171014614923733 0.03163280550884564 1.1174181783150114e-07 6.951784267755089 0.6694868850825999 MSFLFSAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MSFLFSAFK 9 0 E5RFR8;E5RJI3;E5RIU9;Q8WUX9-2;Q8WUX9 E5RFR8 CHMP7 Charged multivesicular body protein 7 0 4728800.0 1619100.0 1405600.0 1704100.0 False True 1346353.3882917215 1398027.753810243 2060419.4311318388 1.0 1.0383809822650552 1.5303704428939997 20.3606257048447 -6.922461493068042 0.8062404830599815 0.9900781927906925 1.6143867937052179 0.9948384202236311 0.017349023680866604 0.09674423138299046 0.09826031636967542 0.015146402132226892 0.046497090576503176 1.1954695178623222e-07 6.922461493068042 0.6243086009145253 MSFLFSAFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MSFLFSAFK 9 0 E5RFR8;E5RJI3;E5RIU9;Q8WUX9-2;Q8WUX9 E5RFR8 CHMP7 Charged multivesicular body protein 7 0 18757500.0 6159800.0 7786400.0 4811300.0 False True 7973982.527810709 7353079.995204309 3935692.768106903 1.0 0.9221339486961642 0.49356676596424204 22.9268690135021 -6.937687907238606 0.6807318025109554 1.005057034692217 0.3854541259914172 0.9978451340323992 0.010336113676061158 0.08883740389927995 0.059532494093193986 0.009893213340568342 0.03727722336319651 1.1542824504643126e-07 6.937687907238606 -0.6196029087007997 down MSGGWELELNGTEAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MSGGWELELNGTEAK 15 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 13933300.0 3956800.0 4770200.0 5206300.0 False True 5187403.1177057065 4058504.754093965 4667602.018356036 1.0 0.7823769739894376 0.8997955070089928 22.306581056495535 -10.132375416056817 4.573018445785038 1.0000165531740284 0.8410862404969389 0.7094915384339532 0.04793591538662514 8.367779245056371e-06 1.587519724642402e-06 0.046418749124212615 0.0154712501630123 7.372666410965453e-11 10.132375416056817 -0.15893031267708946 MSGGWELELNGTEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MSGGWELELNGTEAK 15 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 18402300.0 4894000.0 3763300.0 9745000.0 False True 4738642.648840163 5266005.315350248 7192492.156266513 1.0 1.1112898155844613 1.5178380581255602 22.176042437683382 -6.946961857431544 0.591266985406042 0.9953183067278477 1.6543107646772934 0.9989407091136162 0.007243818062633779 0.0847293136772864 0.04119307320337325 0.007500162961422968 0.034071541101002654 1.1298951450619354e-07 6.946961857431544 0.6589924579494457 MSGGWELELNGTEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MSGGWELELNGTEAK 15 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 70510000.0 0.0 57706000.0 12804000.0 False True 0.0 47407913.44096416 10273283.787807425 0.0 MSGGWELELNGTEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSGGWELELNGTEAK 15 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 6401500.0 2559800.0 0.0 3841700.0 False True 3506227.23599393 0.0 2934369.5822950685 1.0 0.0 0.8369022840766469 21.74148806845016 -9.676699561321465 11.142881854754421 0.9999988370364985 0.4184511419582302 0.39165934081551557 0.3416639267602531 0.0 0.0 0.3308146745852746 0.1102715581950915 2.1052343069600793e-10 9.676699561321465 -0.5815476950782683 MSGGWELELNGTEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MSGGWELELNGTEAK 15 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 11794700.0 4894000.0 2250000.0 4650700.0 False True 4069577.8409608332 2237878.803409967 5623139.867592765 1.0 0.549904410449021 1.3817501685297986 21.956447713117658 -6.759750207701573 1.6133429535425152 0.7384772164775393 1.3847582004943468 0.6899624612479984 0.18930513160204523 0.2833430764175445 1.4534883185588443 0.09258100132973174 0.22254762955833046 1.738800643719136e-07 6.759750207701573 0.6462809840168076 MSGGWELELNGTEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MSGGWELELNGTEAK 15 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 23412000.0 0.0 23412000.0 0.0 False True 0.0 22109101.619197994 0.0 0.0 MSIHLIHMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MSIHLIHMR 9 0 C9JAW5;C9JNU6;Q9Y241;A8MV81;Q9Y241-2 C9JAW5 HIGD1A;HIGD1C HIG1 domain family member 1A, mitochondrial;HIG1 domain family member 1C 0 13969600.0 2967700.0 3717400.0 7284500.0 False True 3890683.43924768 3162778.4103117087 6530769.817858087 1.0 0.8129107545494058 1.6785662261746246 21.891592171272965 -6.850134486632052 1.2344695779397554 0.900152728402405 1.7132561469965424 0.9404974365969475 0.09071911350896465 0.1573091111490202 0.46124987127757316 0.05750318501389477 0.13307501015691017 1.4121001961998258e-07 6.850134486632052 0.8131034185941374 MSIHLIHMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSIHLIHMR 9 0 C9JAW5;C9JNU6;Q9Y241;A8MV81;Q9Y241-2 C9JAW5 HIGD1A;HIGD1C HIG1 domain family member 1A, mitochondrial;HIG1 domain family member 1C 0 9999200.0 2967700.0 2966200.0 4065300.0 False True 4064938.889076949 2835143.4760883013 3105159.867481624 1.0 0.6974627549030866 0.7638884500393391 21.954802232795856 -10.262475526919257 6.953205277209936 1.0000020050101472 0.7306756024712137 0.9563678058583854 0.02711817648224883 8.428883043096564e-07 8.94152407418862e-08 0.026257257077951398 0.008752353824605276 5.464173403695876e-11 10.262475526919257 -0.2693264025389336 MSIHLIHMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MSIHLIHMR 9 0 C9JAW5;C9JNU6;Q9Y241;A8MV81;Q9Y241-2 C9JAW5 HIGD1A;HIGD1C HIG1 domain family member 1A, mitochondrial;HIG1 domain family member 1C 0 4405500.0 1760200.0 1035000.0 1610300.0 False True 1463684.2900815795 1029424.2495685852 1947006.2848140358 1.0 0.7033103084758869 1.330209183775224 20.481172973866993 -6.7780034828962075 1.5435318038554051 0.8315689926892369 1.3348771935091086 0.760282314092144 0.12536570273270517 0.25369928273966613 1.1937179092226713 0.06397799696873477 0.15122249889661155 1.6672338418407476e-07 6.7780034828962075 0.5033082008198717 MSIHLIHMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MSIHLIHMR 9 0 C9JAW5;C9JNU6;Q9Y241;A8MV81;Q9Y241-2 C9JAW5 HIGD1A;HIGD1C HIG1 domain family member 1A, mitochondrial;HIG1 domain family member 1C 0 15456900.0 1905600.0 8121200.0 5430100.0 False True 2466836.7649917323 7669248.080891457 4441877.517531084 1.0 3.1089402386611344 1.8006369860252878 21.234230822405085 -10.152983773974164 5.6276082075088 0.9999751044671813 2.45478861234334 0.6224454996935643 0.5341125662973504 0.00016683659072574064 2.5109271195842458e-05 0.5171610603686313 0.17238408952241263 7.030985884256139e-11 10.152983773974164 1.4548135078761586 MSK(ub)HAQTFGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSKHAQTFGAK 11 1 Q15477 Q15477 SKIV2L Helicase SKI2W 1 3383960.0 588260.0 1070100.0 1725600.0 True False 805755.6191287556 1022819.4436525167 1318048.8198475626 1.0 1.2693916360874615 1.6357922781509577 19.619982818734258 -6.966833059351728 0.3250580168735359 0.9527086146560673 1.9643820191568304 0.9999460973804882 0.001913027357632086 0.07734430173880522 0.01269536950161739 0.005444617114654964 0.03208884021766 1.0793615437296022e-07 6.966833059351728 1.0116734045007632 MSLFYAEATPMLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MSLFYAEATPMLK 13 0 Q9NUQ9;A0A1W2PRQ0;Q9NUQ9-2;A0A087X178;Q9H0Q0 Q9NUQ9 FAM49B;FAM49A Protein FAM49B;Protein FAM49A 0 13194900.0 3247400.0 4405900.0 5541600.0 False True 4257372.847866332 3748556.894063683 4968208.390780753 1.0 0.8804859306467245 1.1669657716896162 22.021532011854646 -6.793410605806054 1.4828600137727133 0.9334986282103169 1.1702975869115797 0.8121325482328937 0.050923828378551715 0.23030473054064104 1.0003460102013322 0.027026885319201614 0.06311802741232028 1.609123562157327e-07 6.793410605806054 0.23679895870126277 MSLFYAEATPMLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSLFYAEATPMLK 13 0 Q9NUQ9;A0A1W2PRQ0;Q9NUQ9-2;A0A087X178;Q9H0Q0 Q9NUQ9 FAM49B;FAM49A Protein FAM49B;Protein FAM49A 0 12810100.0 3247400.0 4924600.0 4638100.0 False True 4448051.537685239 4707014.888525545 3542676.304667927 1.0 1.0582195032243422 0.7964557682511771 22.084742073377537 -6.8483483257416005 1.2430533863070805 1.0310292767566545 0.7863212244374954 0.9378652673556428 0.02797290637855399 0.15928293196209004 0.47445549487113603 0.017616273716224762 0.04072398977398065 1.417919823392392e-07 6.8483483257416005 -0.24470805231915904 MSLFYAEATPMLK(ub)TLSDATTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MSLFYAEATPMLKTLSDATTK 21 1 Q9NUQ9;A0A1W2PRQ0;Q9NUQ9-2;A0A087X178 Q9NUQ9 FAM49B Protein FAM49B 1 3972470.0 1411100.0 1601700.0 959670.0 True False 1849965.7651118378 1362732.603377699 860372.5542046638 1.0 0.7366258495574465 0.4650748518865974 20.81906714224934 -6.9707421526439735 0.2398010403932848 1.0977471767514664 0.09610127985591824 0.9999876051941724 0.0007688505374308667 0.07606264069644067 0.008163731421336787 0.006500243485564614 0.026482826894887398 1.0696897821087412e-07 6.9707421526439735 -1.0016458968955482 down MSLFYAEATPMLK(ub)TLSDATTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MSLFYAEATPMLKTLSDATTK 21 1 Q9NUQ9;A0A1W2PRQ0;Q9NUQ9-2;A0A087X178 Q9NUQ9 FAM49B Protein FAM49B 1 22563700.0 5552400.0 4193300.0 12818000.0 True False 5376142.101230096 5867706.557770618 9460581.268242618 1.0 1.0914344240320673 1.7597342276495958 22.35813984100308 -6.93181659061092 0.7317249509680746 0.9904912847240708 1.9035042182766653 0.9968834595347527 0.01890571191338214 0.09170525913602151 0.07313850380373943 0.0174140827233272 0.059876866224009735 1.1699933933084491e-07 6.93181659061092 0.9130129335525945 MSLFYAEATPMLK(ub)TLSDATTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MSLFYAEATPMLKTLSDATTK 21 1 Q9NUQ9;A0A1W2PRQ0;Q9NUQ9-2;A0A087X178 Q9NUQ9 FAM49B Protein FAM49B 1 69665700.0 9785700.0 23672000.0 36208000.0 True False 14845622.330498109 19447546.64981982 29051472.92946987 1.0 1.309985274909476 1.9569050244386164 23.82353423677521 -6.959204603706877 0.44650944991491875 0.9783776298294063 2.3140093790551277 0.9997395316170542 0.0064337483310128694 0.07998659237547998 0.02219113565789848 0.008603152182336886 0.05353993676366174 1.0984882005528662e-07 6.959204603706877 1.3356317492257213 MSLFYAEATPMLK(ub)TLSDATTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSLFYAEATPMLKTLSDATTK 21 1 Q9NUQ9;A0A1W2PRQ0;Q9NUQ9-2;A0A087X178 Q9NUQ9 FAM49B Protein FAM49B 1 10041100.0 1411100.0 1814600.0 6815400.0 True False 1932821.8035436475 1734424.9719202474 5205742.887568997 1.0 0.8973537905772492 2.6933382467151166 20.882277203772233 -6.893352717692775 1.0023209089764107 0.9111120997054124 2.8583612240351766 0.9829594771786474 0.10750021936047638 0.11646567730260547 0.20628674224496724 0.08133768581650767 0.2053868358449653 1.2783426604680923e-07 6.893352717692775 1.947249124329764 up MSLFYAEATPMLK(ub)TLSDATTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MSLFYAEATPMLKTLSDATTK 21 1 Q9NUQ9;A0A1W2PRQ0;Q9NUQ9-2;A0A087X178 Q9NUQ9 FAM49B Protein FAM49B 1 20687800.0 5552400.0 5901900.0 9233500.0 True False 4617066.613026339 5870105.293264572 11164182.159119656 1.0 1.2713928096040412 2.4180249268272727 22.138545116437356 -6.943619054746828 0.6249870049411347 0.9874823843293907 2.763203867918321 0.9986005521072303 0.022990390546323295 0.0861536735920603 0.047377331799247045 0.02304885647879789 0.09722552439494653 1.1386256034555028e-07 6.943619054746828 1.7757214835889303 up MSLFYAEATPMLK(ub)TLSDATTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MSLFYAEATPMLKTLSDATTK 21 1 Q9NUQ9;A0A1W2PRQ0;Q9NUQ9-2;A0A087X178 Q9NUQ9 FAM49B Protein FAM49B 1 39255700.0 9785700.0 15616000.0 13854000.0 True False 12667781.554985102 14746955.872432765 11332714.154044233 1.0 1.164130894460321 0.8946092182639915 23.59466055886766 -6.7418616443225545 1.6797371860834214 1.097444354774236 0.8943813227765562 0.6133492414615054 0.06895863345899904 0.3144495082773513 1.7427418516914503 0.0324669962489831 0.07951327636481571 1.8119172335211872e-07 6.7418616443225545 -0.20306303199767983 MSLIINTFYSNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MSLIINTFYSNK 12 0 Q58FF6 Q58FF6 HSP90AB4P Putative heat shock protein HSP 90-beta 4 0 15609300.0 3997300.0 3620200.0 7991800.0 False True 6064196.341774227 2974147.025248295 6412217.227069622 1.0 0.4904437220741663 1.0573894487713063 22.531885034033433 -6.669849298096523 1.9377758885016296 0.6747096541748746 1.0551019082716526 0.2784020459573616 0.21645610039259014 0.4614839450151926 3.340613378565249 0.08992912342426058 0.24032680420099578 2.138704099538756e-07 6.669849298096523 0.380392254096778 MSLK(ub)CLAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MSLKCLAAR 9 1 Q9UK73;H3BT12 Q9UK73 FEM1B Protein fem-1 homolog B 1 11105500.0 2673400.0 5154200.0 3277900.0 True False 3504853.2892424297 4385213.450914239 2938734.351837057 1.0 1.2511831705977337 0.8384757104832372 21.74092262459794 -6.741972374610282 1.679428991977001 1.1491123755668398 0.8381269650807299 0.6137515347484642 0.10553332455861228 0.31427581635745494 1.7411984375253056 0.049696095537797316 0.121688897545554 1.8114553152843478e-07 6.741972374610282 -0.31098541048610984 MSLK(ub)CLAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MSLKCLAAR 9 1 Q9UK73;H3BT12 Q9UK73 FEM1B Protein fem-1 homolog B 1 5935260.0 1957800.0 3137500.0 839960.0 True False 1895650.71064554 4390320.111846349 619949.2777401363 1.0 2.315996342148539 0.32703771547081073 20.85426172952965 -6.728264711048818 1.7292771935815368 1.7934743583901813 0.3285301573466095 0.5513191535552829 0.5532937697740973 0.3395048353942054 1.9881162325369264 0.25362158163877396 0.6306522281902266 1.869542270142801e-07 6.728264711048818 -1.4649442010435718 MSLK(ub)CLAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MSLKCLAAR 9 1 Q9UK73;H3BT12 Q9UK73 FEM1B Protein fem-1 homolog B 1 20409400.0 6891700.0 8897800.0 4619900.0 True False 10455212.750758123 7309918.071171296 3706774.740025894 1.0 0.6991649281016536 0.3545384324921662 23.31771908351261 -7.062155443518344 0.28588784437909887 1.0747810973548553 1.4247497493676303e-15 0.9999706149366387 0.001429510846932204 0.07337090627162897 0.010830336437344027 0.006722481394951312 0.03077583044917476 8.666516266178183e-08 7.062155443518344 -1.074781097354854 down MSLK(ub)CLAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSLKCLAAR 9 1 Q9UK73;H3BT12 Q9UK73 FEM1B Protein fem-1 homolog B 1 11713800.0 2673400.0 4995000.0 4045400.0 True False 3661828.225918498 4774304.383743866 3089959.8376282603 1.0 1.3038034798987126 0.8438298158710611 21.80413268612083 -6.728616033827657 1.7286040212682012 1.1831109041379229 0.8441880058621424 0.5527191809150785 0.12772585709742426 0.3388251873791243 1.9828742631631557 0.05857422580303152 0.14555807689972994 1.8680305143643228e-07 6.728616033827657 -0.3389228982757805 MSLK(ub)CLAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MSLKCLAAR 9 1 Q9UK73;H3BT12 Q9UK73 FEM1B Protein fem-1 homolog B 1 7016800.0 1957800.0 3604700.0 1454300.0 True False 1627997.4452458357 3585280.765623068 1758387.4060765393 1.0 2.2022643684687555 1.0800922392178656 20.634667004963926 -6.62985402283045 2.0806885426116013 1.792139988984836 1.0845767782310454 0.11707034226813695 0.5157230494394648 0.5593825443985819 4.614686397001933 0.20272266915586482 0.5714106308438378 2.3450169013296668e-07 6.62985402283045 -0.7075632107537906 MSLK(ub)GTTVTPDK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MSLKGTTVTPDK 12 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 1145045200.0 283883600.0 370683500.0 490478100.0 True False 372174148.7326935 315378966.7129662 439728131.2101562 1.0 0.8473962197183145 1.18151175385903 28.47140260818111 -6.7825624892602345 1.5262691514899867 0.9138779869728714 1.1843558057089862 0.7762177493255751 0.06460632385851517 0.24661989854274435 1.1349495698043457 0.033336836098740774 0.07848152647561664 1.6498235963385807e-07 6.7825624892602345 0.2704778187361149 MSLK(ub)GTTVTPDK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MSLKGTTVTPDK 12 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 2345289100.0 324301600.0 688178500.0 1332809000.0 True False 314006823.2217213 962971763.853468 983706339.4870617 1.0 3.0667224169632465 3.1327546624439537 28.226220667646338 -10.506704651834562 0.6624045138288734 9.523413110384263e-20 3.122567733371298 0.9998981433439652 0.00999343060708485 1.921069214346165 0.33041453240682345 3.309152651999991 0.010665810717846575 3.113833223973637e-11 10.506704651834562 3.122567733371298 MSLK(ub)GTTVTPDK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MSLKGTTVTPDK 12 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 2163137200.0 345355300.0 938798000.0 878983900.0 True False 523929238.9543789 771262162.0377477 705252346.8926709 1.0 1.4720731440317751 1.3460832006630588 28.964796735932 -10.023323128148542 4.651407419578826 0.9999921891258018 1.409078172335412 0.9335838426004459 0.05143517911018081 35531519.14851584 4.309042470439434 4459.5418926052635 0.017607629887361725 9.47713073904675e-11 10.023323128148542 0.4090859832096102 MSLK(ub)GTTVTPDK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MSLKGTTVTPDK 12 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 1127464700.0 283883600.0 254175500.0 589405600.0 True False 388843038.5858297 242945185.96402225 450200136.4693688 1.0 0.6247898556897958 1.1577939985930743 28.534612669704 -6.717548032851721 1.7683354757555807 0.771130021209366 1.1568404498473226 0.5008564076537608 0.1579389180289219 0.3600909022712188 2.1992739239318957 0.07095768846620458 0.17863283484549616 1.916249114383391e-07 6.717548032851721 0.38571042863795657 MSLK(ub)GTTVTPDK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MSLKGTTVTPDK 12 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 1896874960.0 324301600.0 1194982100.0 377591260.0 True False 269671149.39684194 1188544494.2419233 456543846.6812703 1.0 4.40738468649788 1.6929651084381694 28.006625943080614 -6.58936771310321 2.230766882844158 3.30708245677625 1.70072125670585 0.0 1.47676855991571 0.6715303106797681 6.298808489341076 0.5527729281541971 1.6467404490600093 2.5741407330157224e-07 6.58936771310321 -1.6063612000704 MSLK(ub)GTTVTPDK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MSLKGTTVTPDK 12 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 1475880000.0 345355300.0 691731000.0 438793700.0 True False 447069243.82071185 653235561.7695814 358937749.00356823 1.0 1.461150751921437 0.8028683564452781 28.73592305802445 -6.718406018138383 1.7651160163328545 1.2810383224537638 0.8039906895731691 0.504933543111492 0.19409320119861956 0.35843475173661427 2.1816400332807984 0.08734090027895387 0.21966506247535314 1.9124671400761055e-07 6.718406018138383 -0.4770476328805947 MSLK(ub)GTTVTPDK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 MSLKGTTVTPDKR 13 2 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 2 11796500.0 4975400.0 4114100.0 2707000.0 True False 6522797.581842132 3500292.3166361945 2426905.6073775636 1.0 0.5366243966208839 0.3720651418240347 22.63705942822962 -13.999999999999998 0.1442132010499713 3.2230796714183567 0.17839305179217158 0.9995866841002758 0.0054048279115881965 11.940625141428448 0.11926984353361461 7.4542323471453 0.17367638941174995 1.0000000000000041e-14 13.999999999999998 -3.044686619626185 MSLK(ub)GTTVTPDK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 MSLKGTTVTPDKR 13 2 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 2 16676700.0 4679900.0 5289900.0 6706900.0 True False 4531339.136147745 7402184.656464066 4950161.687312872 1.0 1.633553445032351 1.0924279862047985 22.111506038928294 -10.274559553393182 4.326320976806556 0.9997363392956284 1.362990715624526 0.3749906020605137 0.22091354351427037 156432627.51747584 181.274034164874 411215.09046050016 0.07562458189757729 5.31423122181569e-11 10.274559553393182 0.36325437632889757 MSLK(ub)GTTVTPDK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 MSLKGTTVTPDKR 13 2 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 2 16569300.0 5716200.0 6033000.0 4820100.0 True False 8671893.31019685 4956364.013955854 3867405.1222751206 1.0 0.5715434723035523 0.44597009948538346 23.047915576731278 -13.999999999999998 0.17205575948329974 3.172592949908285 0.33758987261778867 0.9995099066008224 0.005250719092191741 12.112174000914822 0.13139086465418495 8.78468932306476 0.10049340062186349 1.0000000000000041e-14 13.999999999999998 -2.8350030772904966 MSLK(ub)GTTVTPDK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSLKGTTVTPDKR 13 2 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 2 11854300.0 4975400.0 4068100.0 2810800.0 True False 6814939.835129373 3888357.890592284 2146946.930243116 1.0 0.5705637884796482 0.3150353461928045 22.70026948975251 -8.812955974128533 0.1858220828109184 1.3916960760681247 2.4723246774038073e-19 0.9997129556557216 0.004788320238845914 0.33190793047369027 0.055534177978717854 0.21814187250046968 0.14195779573735137 1.5383105760421649e-09 8.812955974128533 -1.3916960760681247 down MSLK(ub)GTTVTPDK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MSLKGTTVTPDKR 13 2 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 2 20671700.0 4679900.0 13666000.0 2325800.0 True False 3891544.2047226373 13592378.54551138 2812114.0267158197 1.0 3.492798187674744 0.722621632642163 21.89191131436257 -6.669597397557885 1.9381949738144781 2.591757795416029 0.7337351312627772 0.27723298440388944 1.0590005757608931 0.46222615803165534 3.3470494396516517 0.4398622608036486 1.1760782521246496 2.1399449557047365e-07 6.669597397557885 -1.8580226641532516 MSLK(ub)GTTVTPDKR ddPTM_RPMI8226_Bortezomib_1h_R1 2 MSLKGTTVTPDKR 13 2 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 440542360.0 103403160.0 160065800.0 177073400.0 True False 135562544.1176258 136184606.57160175 158751543.17599165 1.0 1.0045887487434302 1.1710575676290427 27.01438337650881 -6.912804277040703 0.8764160198688544 0.995291586481211 1.1939133603423602 0.9919375711685874 0.007145368919804637 0.1025928850079454 0.12892300153040612 0.005932357518378104 0.01671244786528018 1.2223504112068173e-07 6.912804277040703 0.1986217738611492 MSLK(ub)GTTVTPDKR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MSLKGTTVTPDKR 13 2 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 1052817300.0 176690100.0 273356800.0 602770400.0 True False 171081169.49077094 382509595.77688026 444886749.5156118 1.0 2.2358369241654907 2.6004425316931883 27.35010573355326 -10.159088287888968 0.28472069872084027 3.106139433816556e-11 2.743879850024686 0.9989878214863808 0.021789547770810106 1.621065985357575 0.13163186644027747 1.3995355267379852 0.13887333486893225 6.932848535506469e-11 10.159088287888968 2.7438798499936246 MSLK(ub)GTTVTPDKR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MSLKGTTVTPDKR 13 2 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 950176100.0 178538000.0 394687900.0 376950200.0 True False 270855198.87616324 324252760.5343625 302445827.746858 1.0 1.1971443113507043 1.1166329057067064 28.01294654169622 -10.366926692224537 5.113883006464105 0.999909191065339 1.1568886085287198 0.8350647687451946 0.032868643717055175 3.404972278035187e-05 4.215157811200027e-06 0.03184331173277085 0.01060830914404107 4.296089375126975e-11 10.366926692224537 0.15697941746338073 MSLK(ub)GTTVTPDKR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MSLKGTTVTPDKR 13 2 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 531679160.0 103403160.0 186846200.0 241429800.0 True False 141634102.61732858 178590717.0662432 184409053.64280993 1.0 1.2609301980665288 1.3020102520157313 27.077593438031702 -12.802549833934265 0.27835172817604276 1.1099085438823368e-08 1.3151273338663823 0.9995200005601494 0.002930133274377692 8.004214194095018 0.16227564569768296 4.509534197281853 0.016380086265679494 1.57561521544973e-13 12.802549833934265 1.3151273227672968 MSLK(ub)GTTVTPDKR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MSLKGTTVTPDKR 13 2 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 842636800.0 176690100.0 471202000.0 194744700.0 True False 146925646.84862146 468663541.29972625 235464916.3722434 1.0 3.18980076897394 1.6026127597372064 27.130511008987536 -6.563104888931695 2.3335110300922564 2.506003606251526 1.605337405604532 0.0 0.9553609951994725 0.7516762266797296 7.674207857380433 0.34751201154862177 1.0737452910635883 2.734608195758917e-07 6.563104888931695 -0.9006662006469941 MSLK(ub)GTTVTPDKR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MSLKGTTVTPDKR 13 2 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 851013200.0 178538000.0 424151900.0 248323300.0 True False 231120960.51012495 400547473.9055145 203131007.41222566 1.0 1.7330642492201276 0.8788947872312382 27.78407286378867 -6.679595812636099 1.903993929952947 1.4640012358247938 0.882207235418525 0.3220330237315404 0.3107195693452682 0.43938964124867225 3.0794990194704934 0.1309858050348032 0.3455604051286289 2.0912414933102145e-07 6.679595812636099 -0.5817940004062688 MSLKGTTVTPDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MSLKGTTVTPDK 12 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 0 4793400.0 1047700.0 1101500.0 2644200.0 False True 1014441.3369819856 1541334.6942466157 1951604.6957003537 1.0 1.519392633222306 1.9238221319987576 19.95225400879805 -6.973925674639928 0.13465167044630177 0.41481951082017543 3.0388998031748913 0.9999990921286213 0.00036023604295286425 0.07504827704453901 0.004058500796748476 0.024191928287156418 0.05400078298852779 1.0618772718201935e-07 6.973925674639928 2.6240802923547157 MSLKGTTVTPDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MSLKGTTVTPDK 12 1 Q16186;A0A087WX59;A0A087WUX6 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 0 5415600.0 1047700.0 2954800.0 1413100.0 False True 871208.9709797024 2938881.9059181213 1708572.6765638145 1.0 3.373337515812371 1.9611513809855168 19.732659284232327 -10.175516423073176 6.0378510662546425 0.9999824656441623 2.6672444483989577 0.650161376228829 0.5765225753598834 0.0001360802346353683 1.8582166170018733e-05 0.5582214220947023 0.18607186109011267 6.675496567472805e-11 10.175516423073176 1.6672619827547954 MSLMVVSMACVGFFLLQGAWTHEGGQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MSLMVVSMACVGFFLLQGAWTHEGGQDK 28 0 A0A5F9ZHH1;B0L653;A0A0G2JN68;A0A1W2PQ83;Q8NHK3 A0A5F9ZHH1 KIR2DL5B Killer cell immunoglobulin-like receptor 2DL5B 0 21364300.0 5758200.0 7869100.0 7737000.0 False True 7549055.962488124 6695060.95351156 6936449.458544582 1.0 0.886873933214943 0.918849918852419 22.847864810663584 -10.826301054151752 6.913385604066415 1.006117045165186 0.9028619260332966 0.9248383856589775 0.01305414147239659 0.001296248429466331 3.256821470054259e-05 0.013311885947380569 0.0042132060434689625 1.4917599588949328e-11 10.826301054151752 -0.10325511913188934 MSLMVVSMACVGFFLLQGAWTHEGGQDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MSLMVVSMACVGFFLLQGAWTHEGGQDK 28 0 A0A5F9ZHH1;B0L653;A0A0G2JN68;A0A1W2PQ83;Q8NHK3 A0A5F9ZHH1 KIR2DL5B Killer cell immunoglobulin-like receptor 2DL5B 0 33723800.0 9189800.0 11669000.0 12865000.0 False True 8898074.829242196 16328492.553031111 9495270.558272846 1.0 1.8350590286530246 1.0671151614805547 23.085061800375826 -10.238228260340824 5.222885125776902 0.9999526222784955 1.4510870950668586 0.3150897396204363 0.3135117709457447 0.00017299178828767092 2.523108808325127e-05 0.3035882548425731 0.10118548897601787 5.777922863979816e-11 10.238228260340824 0.45113447278836316 MSLMVVSMACVGFFLLQGAWTHEGGQDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MSLMVVSMACVGFFLLQGAWTHEGGQDK 28 0 A0A5F9ZHH1;B0L653;A0A0G2JN68;A0A1W2PQ83;Q8NHK3 A0A5F9ZHH1 KIR2DL5B Killer cell immunoglobulin-like receptor 2DL5B 0 62241000.0 19221000.0 25570000.0 17450000.0 False True 29159662.24332482 21006833.720678132 14000999.85139331 1.0 0.7204073060032435 0.48014958933889557 24.797470673221298 -6.9785340865631875 0.17631271119431396 1.1954330006767584 1.642127991427653e-11 0.9999970623889406 0.00036404856535278456 0.07472378617779922 0.005514071504584666 0.00954178254819538 0.027095422173374205 1.0506689875494309e-07 6.9785340865631875 -1.195433000660337 down MSLMVVSMACVGFFLLQGAWTHEGGQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSLMVVSMACVGFFLLQGAWTHEGGQDK 28 0 A0A5F9ZHH1;B0L653;A0A0G2JN68;A0A1W2PQ83;Q8NHK3 A0A5F9ZHH1 KIR2DL5B Killer cell immunoglobulin-like receptor 2DL5B 0 20971900.0 5758200.0 6891700.0 8322000.0 False True 7887162.149503961 6587201.906195724 6356514.99696999 1.0 0.8351802310302453 0.8059318264896791 22.911074872186475 -13.999999999999792 0.24320537248947988 2.1081406780055865 0.7933872608179451 0.9995303929728454 0.001851279574462532 13.738857511739088 0.15607224645104778 7.407929117742234 0.014027689755852212 1.0000000000004785e-14 13.999999999999792 -1.3147534171876414 MSLMVVSMACVGFFLLQGAWTHEGGQDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MSLMVVSMACVGFFLLQGAWTHEGGQDK 28 0 A0A5F9ZHH1;B0L653;A0A0G2JN68;A0A1W2PQ83;Q8NHK3 A0A5F9ZHH1 KIR2DL5B Killer cell immunoglobulin-like receptor 2DL5B 0 26428200.0 9189800.0 11139000.0 6099400.0 False True 7641725.877168338 11078991.996081607 7374756.339560785 1.0 1.4498023318505842 0.9650642352396867 22.865467075810102 -6.662966996094585 1.962494763579964 1.288821638111156 0.9670773654418922 0.24828286887071727 0.19138043443844166 0.4774185211630127 3.537765989001926 0.07870523126052899 0.21221352810803684 2.1728662980442635e-07 6.662966996094585 -0.32174427266926375 MSLMVVSMACVGFFLLQGAWTHEGGQDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MSLMVVSMACVGFFLLQGAWTHEGGQDK 28 0 A0A5F9ZHH1;B0L653;A0A0G2JN68;A0A1W2PQ83;Q8NHK3 A0A5F9ZHH1 KIR2DL5B Killer cell immunoglobulin-like receptor 2DL5B 0 74036000.0 19221000.0 26738000.0 28077000.0 False True 24881963.40255355 25250006.795409035 22967274.094348192 1.0 1.0147915735949404 0.9230491068076702 24.568596995313747 -6.865580002058751 1.1571277340338562 1.0081799355956347 0.9181068447249102 0.9600743589768402 0.008035986477311654 0.1411684630489387 0.3560420354209138 0.005402647976105858 0.012702472487925671 1.3627619465969108e-07 6.865580002058751 -0.09007309087072446 MSLPDVDLDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MSLPDVDLDLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 6794100.0 970000.0 3767700.0 2056400.0 False True 1271679.3934933625 3205573.846379574 1843623.4543816822 1.0 2.5207405756365318 1.449754917642538 20.27830356406745 -10.374609033496744 5.834072201066344 0.9997787061229203 1.9852477466395364 0.5301630726301978 0.437228063987369 0.001258765776202836 0.0001349340307067766 0.4234355502161923 0.14111475085979844 4.22076299734847e-11 10.374609033496744 0.9854690405166161 MSLPDVDLDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSLPDVDLDLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7721900.0 970000.0 2648700.0 4103200.0 False True 1328635.2132643606 2531671.675920397 3134108.668056625 1.0 1.9054678444810016 2.3588932739155295 20.34151362559034 -9.571625900840564 0.186331846693401 1.9103839644488743e-20 2.85272189098836 0.9995631155873932 0.011807515889895998 1.0152933429249111 0.07607982761309091 0.8406555539359019 0.2886609176161212 2.681477141673277e-10 9.571625900840564 2.85272189098836 MSLPDVDLDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MSLPDVDLDLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 6440700.0 1845200.0 2105500.0 2490000.0 False True 1534365.5562200497 2094157.2535909715 3010647.487540802 1.0 1.3648359382818678 1.9621448587242873 20.54921080921656 -6.963762238333108 0.37869935042094927 0.9583658853006761 2.3896935989649832 0.9998853062615691 0.00424736306623817 0.07838358864344482 0.0163569220720164 0.007784120312532895 0.05050374130759103 1.0870205680592117e-07 6.963762238333108 1.4313277136643072 MSLPDVDLDLKGPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MSLPDVDLDLKGPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 4946200.0 1705700.0 1847200.0 1393300.0 False True 2236189.2180222976 1571604.960329204 1249134.6814773371 1.0 0.7028049986392222 0.5585997246610827 21.092610838163885 -13.999999998901014 0.09523790281917324 2.4905929621183063 0.2274553700066893 0.9998173055472858 0.002483958585561936 12.118390109363844 0.09090685375231357 3.596773624484196 0.29625446812325323 1.0000000025305083e-14 13.999999998901014 -2.263137592111617 MSLPDVDLDLKGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSLPDVDLDLKGPK 14 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 6290800.0 1705700.0 2724400.0 1860700.0 False True 2336343.3848092994 2604026.9996139733 1421240.9823193997 1.0 1.1145737465413386 0.60831853380808 21.155820899686777 -6.847235964569553 1.2483481435694628 1.0610251816593348 0.589133217974249 0.9361888891071424 0.05475361513952681 0.16052183247008292 0.48277143258150745 0.034344236900245524 0.07934725186077068 1.4215562052578198e-07 6.847235964569553 -0.4718919636850858 MSMK(ub)EVDEQMLNVQNK ddPTM_RPMI8226_Bortezomib_1h_R1 4 MSMKEVDEQMLNVQNK 16 1 P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P07437;P68371;Q13885;Q9BVA1 TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 315221200.0 104796900.0 117573300.0 92851000.0 True False 137389750.75462317 100031821.93713377 83243669.20968378 1.0 0.7280879497029562 0.6058943170976138 27.033699142534385 -13.999999999966553 0.10805432668879435 2.3167457110870333 0.3753227509634759 0.9997529515905257 0.002588986178183466 12.024450357613837 0.09942530437677029 3.4671410854922633 0.20490754038931586 1.0000000000770146e-14 13.999999999966553 -1.9414229601235573 MSMK(ub)EVDEQMLNVQNK ddPTM_RPMI8226_Bortezomib_2h_R1 4 MSMKEVDEQMLNVQNK 16 1 P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P07437;P68371;Q13885;Q9BVA1 TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 296052100.0 82999800.0 84618400.0 128433900.0 True False 80365016.78079344 118406968.39912643 94793208.65558946 1.0 1.473364570085235 1.1795332403668985 26.26006429123522 -10.172800816993695 4.621501760223174 0.9999509196898945 1.3264489052296047 0.6220402680097465 0.11995613805434616 14388077.50977047 31670889.762391638 4554.039539433906 0.041064177137535914 6.717368648764799e-11 10.172800816993695 0.3264979855397102 MSMK(ub)EVDEQMLNVQNK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MSMKEVDEQMLNVQNK 16 1 P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P07437;P68371;Q13885;Q9BVA1 TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 724799500.0 134530000.0 146711500.0 443558000.0 True False 204091845.46040758 120529686.56281851 355888566.8816223 1.0 0.5905659106120457 1.7437667148277232 27.60464329938793 -6.8107217421155815 1.411472861866579 0.7770534872048644 1.7642817757394489 0.8617144299853887 0.17750801047226175 0.20581462816145357 0.8080039551975905 0.09888223406671172 0.22866362726072645 1.5462448205473953e-07 6.8107217421155815 0.9872282885345844 MSMK(ub)EVDEQMLNVQNK ddPTM_RPMI8226_Carfilzomib_1h_R1 4 MSMKEVDEQMLNVQNK 16 1 P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P07437;P68371;Q13885;Q9BVA1 TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 266548500.0 104796900.0 69255000.0 92496600.0 True False 143543145.95973587 66195085.10434072 70650808.10727398 1.0 0.46115113795059615 0.4921921394079775 27.096909204057276 -9.965529125484393 5.268332441024096 1.0000015874694501 0.47667163869513196 0.9973682792115132 0.01267243578965121 34814666.410570934 31.4593764646913 784.2988358902518 0.00433811183623081 1.0826071088311097e-10 9.965529125484393 -0.5233299487743182 MSMK(ub)EVDEQMLNVQNK ddPTM_RPMI8226_Carfilzomib_2h_R1 5 MSMKEVDEQMLNVQNK 16 1 P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P07437;P68371;Q13885;Q9BVA1 TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 293198600.0 85776800.0 120627400.0 86794400.0 True False 71327209.75654458 119977556.25353594 104942707.74803647 1.0 1.682072755446984 1.4712857562524733 26.087949202203948 -10.314430234369663 5.172985262621206 0.9998361327991439 1.5766792558498006 0.9089232620252787 0.08605343207341763 0.0001626765620406789 2.1559348727277403e-05 0.08334423076569 0.027773625775325373 4.848079865547268e-11 10.314430234369663 0.5768431230506568 MSMK(ub)EVDEQMLNVQNK ddPTM_RPMI8226_Carfilzomib_8h_R1 3 MSMKEVDEQMLNVQNK 16 1 P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P07437;P68371;Q13885;Q9BVA1 TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 721831300.0 148531000.0 104573300.0 468727000.0 True False 192276307.4837253 98753703.92768152 383423495.5451633 1.0 0.5136030810038322 1.9941276206254226 27.51860576212218 -6.818198456519525 1.379695618713098 0.7373498685212916 2.0252063304837233 0.8801819172258509 0.2132805592645466 0.19583156881697958 0.7329764607815141 0.12149354160451013 0.2801604581422758 1.519852854468528e-07 6.818198456519525 1.2878564619624318 MSPLDMK(ub)DGFLAFQTSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MSPLDMKDGFLAFQTSR 17 1 I3L3S0;Q9Y5R8;I3L3V5 I3L3S0 TRAPPC1 Trafficking protein particle complex subunit 1 1 4365700.0 1325600.0 1593100.0 1447000.0 True False 1283519.5535967553 2229233.1379067483 1067987.2909304933 1.0 1.7368127596185488 0.8320771490685245 20.29167384393808 -6.690179066380049 1.8661777708045386 1.4618643909956333 0.8352301025149794 0.37112921004303523 0.3116091796543395 0.4162585682393258 2.8108988523663383 0.1335851436277586 0.3477354234473176 2.040896277838159e-07 6.690179066380049 -0.6266342884806538 MSPLDMK(ub)DGFLAFQTSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MSPLDMKDGFLAFQTSR 17 1 I3L3S0;Q9Y5R8;I3L3V5 I3L3S0 TRAPPC1 Trafficking protein particle complex subunit 1 1 4016100.0 1325600.0 1369900.0 1320600.0 True False 1102295.134037123 1362520.0767961382 1596731.3542354945 1.0 1.2360755615476129 1.4485515765523826 20.072079119372358 -6.972375289424496 0.19320088522908566 0.8618821776389597 1.8285689774801352 0.9999954669377602 0.00039001857776744793 0.07553919515691575 0.006186948119294452 0.0073004141150279055 0.022960662832457866 1.065674835416439e-07 6.972375289424496 0.9666867998411756 MSQLEVK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MSQLEVKEK 9 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 22282000.0 1171900.0 5559100.0 15551000.0 True False 1777857.977366028 4567035.171553457 12477338.033754567 1.0 2.568841397736232 7.018186037694796 20.76170864965977 -6.952706784008383 0.5282936420577068 0.9289563663435974 8.859464690251443 0.9993969344710849 0.06259673192440063 0.08241672408159871 0.0316025851273531 0.07001307357217221 0.36785747487338505 1.1150471088865593e-07 6.952706784008383 7.930508323907845 MSQSHEDSLTSVAWNPDGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 MSQSHEDSLTSVAWNPDGKR 20 1 A0A499FIZ0;Q9H7D7-2;Q9H7D7;H0Y9R3 A0A499FIZ0 WDR26 WD repeat-containing protein 26 1 14932100.0 6649300.0 6070700.0 2212100.0 True False 6438221.611142796 8494762.168282278 1632684.6484224922 1.0 1.3194268046909372 0.2535924898261909 22.61823080625069 -6.826364530223841 1.3440777915049587 1.1711551095219674 0.226983893828962 0.898405874374546 0.1423523621731008 0.18534024690919254 0.6560966579758908 0.08318656765957914 0.1914892767269548 1.491541940598607e-07 6.826364530223841 -0.9441712156930054 down MSQSHEDSLTSVAWNPDGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MSQSHEDSLTSVAWNPDGKR 20 1 A0A499FIZ0;Q9H7D7-2;Q9H7D7;H0Y9R3 A0A499FIZ0 WDR26 WD repeat-containing protein 26 1 9394200.0 6649300.0 1552100.0 1192800.0 True False 5529187.563935599 1543738.5292322715 1442208.9651159307 1.0 0.27919807591650225 0.2608356016936033 22.398636081684966 MSSK(ub)PINFSVILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MSSKPINFSVILK 13 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 5671700.0 1522800.0 1783600.0 2365300.0 True False 1996405.5468161777 1517493.8324183484 2120561.445559714 1.0 0.760113011526347 1.0621897183873974 20.92897338666786 -6.695133124886855 1.8483916725106126 0.8503314284266796 1.0612080864609323 0.3944110941607655 0.10135275132770724 0.4057510693160474 2.6915922953886575 0.04380400535094642 0.1133271014790555 2.0177477658694637e-07 6.695133124886855 0.2108766580342527 MSSK(ub)PINFSVILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSSKPINFSVILK 13 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 8307500.0 1522800.0 2534500.0 4250200.0 True False 2085820.3121226479 2422517.4095292976 3246390.295616655 1.0 1.1614219093801075 1.556409378482342 20.99218344819075 -6.955919813153185 0.4895613355102744 0.9913215392155655 1.7432465681048024 0.9995876715804423 0.004746069091818004 0.08119213744181315 0.026771655589086136 0.005681625834064268 0.03257740377553181 1.1068281265794894e-07 6.955919813153185 0.7519250288892368 MSSKPINFSVILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MSSKPINFSVILK 13 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 0 22827900.0 7305500.0 7147600.0 8374800.0 False True 9577581.246562636 6081205.941126582 7508256.032754191 1.0 0.6349417232361363 0.7839407298631772 23.19122992839837 -10.105806855122285 5.121717731762513 1.0000076459085179 0.709441227559864 0.8352654975459108 0.06082858973824781 5.310822927409829e-06 9.272529953223156e-07 0.058898578196131965 0.01963234291884718 7.837781368901063e-11 10.105806855122285 -0.2905664183486538 MSSKPINFSVILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MSSKPINFSVILK 13 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 0 21614400.0 6147100.0 6069200.0 9398100.0 False True 5951963.675252416 8492663.210459884 6936455.673043446 1.0 1.426867446414602 1.1654062510301322 22.504934291050173 -10.209388473218626 4.303497113535558 0.9998878413643059 1.296136848732447 0.631056912654278 0.10674108611626633 75105740.82980837 18.67243316981572 87257.16933242434 0.03654031291206124 6.174638361847499e-11 10.209388473218626 0.2962490073681411 MSSKPINFSVILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MSSKPINFSVILK 13 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 0 48536800.0 9695800.0 16969000.0 21872000.0 False True 14709237.457927736 13940749.370597862 17548989.613161836 1.0 0.947754729670525 1.1930591006744253 23.81021912194084 -6.851040739175529 1.23021376517256 0.9720952832779339 1.2030553159251363 0.9417830825738198 0.02545565962024997 0.1563194939917718 0.45475658397913526 0.01618786525172945 0.03748186164712408 1.409156605696964e-07 6.851040739175529 0.23096003264720233 MSSKPINFSVILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSSKPINFSVILK 13 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 0 27543100.0 7305500.0 6871600.0 13366000.0 False True 10006540.77371421 6567989.990657532 10209226.081410825 1.0 0.6563696825091371 1.0202552822478914 23.254439989921263 -11.029613993476163 12.626559954501888 1.3824717463685596 0.8383124823770871 0.20838862542742354 0.14855567401776398 0.04435352341470246 0.00010402566982801061 0.003988673104653237 0.04794613762128482 9.340841579675031e-12 11.029613993476163 -0.5441592639914725 MSSKPINFSVILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MSSKPINFSVILK 13 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 0 13729100.0 6147100.0 3169500.0 4412500.0 False True 5111586.012703371 3152425.274403504 5335133.348905133 1.0 0.6167215550259864 1.0437334587828904 22.28533956648445 -6.670149424697826 1.9370711285229316 0.7553859340280524 1.0420009655059401 0.2796636411923219 0.162802666136239 0.46074116182080777 3.3332050601913106 0.0676618906253574 0.18072537538874975 2.137226622207905e-07 6.670149424697826 0.2866150314778877 MSSKPINFSVILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MSSKPINFSVILK 13 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 0 41209800.0 9695800.0 14079000.0 17435000.0 False True 12551404.23279116 13295491.273564361 14262008.898207106 1.0 1.0592831707889097 1.1362879111921922 23.58134544403329 -6.967538752003312 0.3114228246858637 0.9883343508285449 1.2096895154944514 0.999956307514166 0.0003687671852296689 0.07710974231261152 0.011874999480678628 0.001210616851205891 0.006827187355159133 1.0776090945762716e-07 6.967538752003312 0.22135516466590643 MSSLLPTMWLGAQNGCLYVHSSVAQWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MSSLLPTMWLGAQNGCLYVHSSVAQWR 27 0 O60271-9;O60271-4;O60271;A0A087X2D8;O60271-2;H0YBS5 O60271-9 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 0 53656000.0 19616000.0 17786000.0 16254000.0 False True 29758906.12169295 14611949.337347742 13041389.775618713 1.0 0.4910109692068374 0.43823485051125943 24.826818161026665 -13.999999999999998 0.32022644034415454 6.225901200509934 0.42778363486353205 0.9996942123759681 0.004429349698224551 18.030930064134115 0.18047659074253578 63.136547771045045 0.017555529612103337 1.0000000000000041e-14 13.999999999999998 -5.798117565646402 MSSLLPTMWLGAQNGCLYVHSSVAQWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MSSLLPTMWLGAQNGCLYVHSSVAQWR 27 0 O60271-9;O60271-4;O60271;A0A087X2D8;O60271-2;H0YBS5 O60271-9 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 0 41429100.0 19616000.0 7889100.0 13924000.0 False True 25393298.689167622 7450064.649923744 11389974.872304888 1.0 0.2933870365216404 0.448542547060405 24.597944483119115 -10.21367490784026 8.111662307315505 1.0000002631911848 0.3709647918008112 0.9563616885245876 0.06334197193349853 3.0145095705893477e-07 2.9349151733299652e-08 0.06133062573427487 0.020443533534531457 6.1139951820815e-11 10.21367490784026 -0.6290354713903736 MSSPEDDSDTK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSSPEDDSDTKR 12 1 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 1 1644500.0 681850.0 440530.0 522120.0 True False 933948.3713034061 421065.9279620993 398806.00939893833 1.0 0.45084497269850715 0.4270107659616879 19.832983274346848 MSSYAFFVQTCR ddPTM_RPMI8226_Bortezomib_1h_R1 2 MSSYAFFVQTCR 12 0 P26583;D6R9A6;Q5T7C4;P09429;B2RPK0 P26583;Q5T7C4 HMGB2;HMGB1;HMGB1P1 High mobility group protein B2;High mobility group protein B1;Putative high mobility group protein B1-like 1 0 668053300.0 212935400.0 275627000.0 179490900.0 False True 279160371.46934694 234504525.98563102 160918903.46628907 1.0 0.8400351552454524 0.5764389215392582 28.05651891575245 -6.963648130905427 0.3805418820708822 1.0179965632076557 0.3891480641313022 0.9998825068124715 0.0018929320723435812 0.07842275439245214 0.016496279374904225 0.003428558605356439 0.02226786785352354 1.0873062116083203e-07 6.963648130905427 -0.6288484990763535 MSSYAFFVQTCR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MSSYAFFVQTCR 12 0 P26583;D6R9A6;Q5T7C4;P09429;B2RPK0 P26583;Q5T7C4 HMGB2;HMGB1;HMGB1P1 High mobility group protein B2;High mobility group protein B1;Putative high mobility group protein B1-like 1 0 339736700.0 204099500.0 59028200.0 76609000.0 False True 197620473.0909181 82598468.08799651 56542804.679263346 1.0 0.417965136891439 0.2861181526129129 27.558157174122343 -13.999999999999927 0.20863906966922452 4.347428857960419 0.20742804241235582 0.9994892927532737 0.007009180667261409 12.715170122605963 0.14478632505233346 17.436523472493434 0.07885098756061386 1.0000000000001677e-14 13.999999999999927 -4.140000815548063 MSSYAFFVQTCR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MSSYAFFVQTCR 12 0 P26583;D6R9A6;Q5T7C4;P09429;B2RPK0 P26583;Q5T7C4 HMGB2;HMGB1;HMGB1P1 High mobility group protein B2;High mobility group protein B1;Putative high mobility group protein B1-like 1 0 1447228000.0 390117000.0 424314000.0 632797000.0 False True 591836010.3729864 348591851.5195862 507724395.58522254 1.0 0.5890007458314287 0.8578802010801013 29.140622239351554 -10.172023878663225 7.04415073363962 1.0000004068178692 0.7234404734557651 0.5851637654506125 0.10976957794612541 7.013394142897013e-07 8.251377407280233e-08 0.10628409361353267 0.03542797894213005 6.729396552589034e-11 10.172023878663225 -0.27655993336210405 MSSYAFFVQTCR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MSSYAFFVQTCR 12 0 P26583;D6R9A6;Q5T7C4;P09429;B2RPK0 P26583;Q5T7C4 HMGB2;HMGB1;HMGB1P1 High mobility group protein B2;High mobility group protein B1;Putative high mobility group protein B1-like 1 0 654818900.0 212935400.0 191591700.0 250291800.0 False True 291663371.74281645 183126545.18497312 191178031.76142913 1.0 0.627869533602083 0.6554749422906847 28.11972897727534 -9.931357500541516 5.027584526049909 1.0000014483715847 0.641672237937289 0.9955684063279081 0.011269860933271526 15427620.758859321 2.1576747190855454 271.3054045410623 0.0038579731538433124 1.1712308401798004e-10 9.931357500541516 -0.35832921043429566 MSSYAFFVQTCR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MSSYAFFVQTCR 12 0 P26583;D6R9A6;Q5T7C4;P09429;B2RPK0 P26583;Q5T7C4 HMGB2;HMGB1;HMGB1P1 High mobility group protein B2;High mobility group protein B1;Putative high mobility group protein B1-like 1 0 374026500.0 204099500.0 33154400.0 136772600.0 False True 169717777.39092478 32975790.666566838 165371118.29494897 1.0 0.19429779940265782 0.9743888992491117 27.33856244955662 -10.881408077266448 11.77005025753267 1.0167071296596841 0.5843433493258847 0.27459751237777696 0.31847085791838947 0.12053172548570679 0.0012144433366539237 0.26619791234509405 0.1027860274141926 1.3139895844538752e-11 10.881408077266448 -0.4323637803337994 MSSYAFFVQTCR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MSSYAFFVQTCR 12 0 P26583;D6R9A6;Q5T7C4;P09429;B2RPK0 P26583;Q5T7C4 HMGB2;HMGB1;HMGB1P1 High mobility group protein B2;High mobility group protein B1;Putative high mobility group protein B1-like 1 0 1720854000.0 390117000.0 769014000.0 561723000.0 False True 505014146.8557309 726217694.882365 459495177.76470184 1.0 1.438014557421549 0.9098659525194794 28.911748561444004 -6.686524974391857 1.8786362621665298 1.2755025086850966 0.9117605627072365 0.3541684499080977 0.1853833383644715 0.42423855610339467 2.900080123659426 0.07902077534460324 0.2066912031070272 2.0581405324043335e-07 6.686524974391857 -0.36374194597786014 MSTGTFVVSQPLNYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MSTGTFVVSQPLNYR 15 0 P49189 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 8763200.0 2603400.0 2824400.0 3335400.0 False True 3413082.61136146 2403010.5294249724 2990284.8034160025 1.0 0.7040587067614003 0.8761243555787226 21.702643903643494 -10.219022317993074 5.261183370199037 1.0000163366333965 0.7900915317186357 0.664914568515862 0.07024550697740851 1.3461727426166722e-05 1.998250911569827e-06 0.06802021081002319 0.02267163988909053 6.039175938105124e-11 10.219022317993074 -0.20992480491476084 MSTGTFVVSQPLNYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSTGTFVVSQPLNYR 15 0 P49189 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 8908100.0 2603400.0 2828200.0 3476500.0 False True 3565947.334239621 2703240.7723932797 2655422.3007649747 1.0 0.7580708628075408 0.7446611101818752 21.765853965166386 MSVFQTQLPTLGVGALKPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MSVFQTQLPTLGVGALKPR 19 1 O95486 O95486 SEC24A Protein transport protein Sec24A 0 9889900.0 1219200.0 3694400.0 4976300.0 False True 1598383.0067495932 3143209.920658408 4461400.2120402455 1.0 1.9664935796898344 2.7911959731809013 20.608181719598917 -6.972968198272117 0.17317969742319386 0.3018187656751201 4.4780236945459375 0.9999972412288327 0.0012158318606613613 0.07535081259457593 0.0054204538988723745 0.03376014596191745 0.09455356923842072 1.0642209442104383e-07 6.972968198272117 4.176204928870817 MSVFQTQLPTLGVGALKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MSVFQTQLPTLGVGALKPR 19 1 O95486 O95486 SEC24A Protein transport protein Sec24A 0 11375300.0 3330600.0 2352000.0 5692700.0 False True 3224871.926078265 3291165.8655179655 4201611.092660689 1.0 1.0205570766713579 1.3028768859575228 21.620810435199367 -6.9215380303530205 0.8132238543300998 0.994109495383256 1.350056294341323 0.9945979221403676 0.010156600354940419 0.09727520614233896 0.10098204095997157 0.008823004991932757 0.026831112204548473 1.1980142107397122e-07 6.9215380303530205 0.355946798958067 MSVFQTQLPTLGVGALKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSVFQTQLPTLGVGALKPR 19 1 O95486 O95486 SEC24A Protein transport protein Sec24A 0 13855500.0 1219200.0 4693200.0 7943100.0 False True 1669971.1876411403 4485838.905663014 6067103.37327953 1.0 2.6861774256113544 3.6330587127370775 20.67139178112181 -8.750855245406706 0.23504426997606337 3.1971047663057365e-21 4.415958149718035 0.9993670847511614 0.027396193572494548 0.2985777339351927 0.0710836072128753 0.6470112300240675 0.41018560051193664 1.7747809341386989e-09 8.750855245406706 4.415958149718035 MSVFQTQLPTLGVGALKPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MSVFQTQLPTLGVGALKPR 19 1 O95486 O95486 SEC24A Protein transport protein Sec24A 0 8145500.0 3330600.0 2629300.0 2185600.0 False True 2769541.470597494 2615135.439024814 2642598.8549273736 1.0 0.944248521565063 0.9541647536179575 21.401215710633643 -10.062702726295042 6.626335934968887 1.0000000312579425 0.9492066375920787 0.9722091837786568 0.004048284783437593 1.8690398640624525e-09 2.6443877965826963e-10 0.003919737281492697 0.001306578295579825 8.655601902687243e-11 10.062702726295042 -0.05079339366586377 MSVLNMVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MSVLNMVVR 9 0 Q2NL82 Q2NL82 TSR1 Pre-rRNA-processing protein TSR1 homolog 0 2538900.0 0.0 1247900.0 1291000.0 False True 0.0 1241177.3150112445 1560942.1310904282 0.0 MSVQPTVSLGGFEITPPVVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MSVQPTVSLGGFEITPPVVLR 21 0 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 0 44164300.0 29238000.0 9644000.0 5282300.0 False True 38331301.14119473 8205152.792017571 4735738.26739951 1.0 0.2140588121909453 0.12354754799361617 25.19201963490643 -13.999999999999998 0.30504795735931695 8.381146139560666 0.10242070353491099 0.9996610612770412 0.007245705416854179 16.92475474521245 0.17556212205724508 79.07460662101289 0.03201613262803475 1.0000000000000041e-14 13.999999999999998 -8.278725436025756 MSVQPTVSLGGFEITPPVVLR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MSVQPTVSLGGFEITPPVVLR 21 0 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 0 2589470000.0 1225520000.0 528290000.0 835660000.0 False True 1186616538.4157324 739238951.9959552 616775576.7373705 1.0 0.6229804895378612 0.5197766563753071 30.14420664953551 -13.999999999999998 0.1818014451328658 2.9671342628090907 0.4393033042352004 0.999496075801157 0.004633319846553905 12.22856326119271 0.13518073212946774 8.500926054001905 0.07589193432044397 1.0000000000000041e-14 13.999999999999998 -2.5278309585738903 MSVQPTVSLGGFEITPPVVLR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MSVQPTVSLGGFEITPPVVLR 21 0 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 0 2083470100.0 646061300.0 753546000.0 683862800.0 False True 980122225.5076929 619069828.818229 548697017.832287 1.0 0.6316251307305651 0.559825094822299 29.868386429896688 -13.999999999999998 0.22990821070764775 3.3244542338705996 0.5248848004679019 0.9995096680826899 0.0042696511526206056 13.288456638223792 0.15182154970026085 14.099533971023908 0.03729205185232799 1.0000000000000041e-14 13.999999999999998 -2.7995694334026977 MSVQPTVSLGGFEITPPVVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSVQPTVSLGGFEITPPVVLR 21 0 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 0 54772000.0 29238000.0 3560000.0 21974000.0 False True 40048078.72724055 3402707.428654291 16784193.76873568 1.0 0.08496555981697526 0.41910109803392737 25.25522969642932 -10.522854460291237 6.224225408788854 1.0008017165585004 0.2520333304321994 0.8698128997638225 0.13641026226029354 0.001519017016771852 0.00011644671361499388 0.13220269079783475 0.04402622283215855 3.0001677594520244e-11 10.522854460291237 -0.748768386126301 MSVQPTVSLGGFEITPPVVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MSVQPTVSLGGFEITPPVVLR 21 0 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 0 2352911000.0 1225520000.0 431489000.0 695902000.0 False True 1019074179.7413809 429164483.1131389 841411890.7126977 1.0 0.4211317405981688 0.8256630453793167 29.924611924969785 -9.883069115667231 6.5182388004783505 1.0000000197451806 0.6233973929887436 0.5360883609528586 0.1651492136161013 4.7375414217523585e-08 8.042197129157093e-09 0.15990504564186475 0.05330167949785557 1.308973590206373e-10 9.883069115667231 -0.37660262675643696 MSVQPTVSLGGFEITPPVVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MSVQPTVSLGGFEITPPVVLR 21 0 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 0 1330594400.0 646061300.0 357393900.0 327139200.0 False True 836339088.6221416 337504615.29051244 267603222.3316521 1.0 0.4035499713956299 0.3199697658189397 29.639512751989137 -13.999999999999998 0.2768521881082359 5.777755360519316 0.2940180775407755 0.9995982344774582 0.006069306528928918 15.230597641590965 0.16663625975435756 41.124214094764234 0.03356404698118571 1.0000000000000041e-14 13.999999999999998 -5.48373728297854 MSYLELMEHPFFTLHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MSYLELMEHPFFTLHK 16 0 P46734-2;P46734;P46734-3 P46734-2 MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 0 13309600.0 4880900.0 3339500.0 5089200.0 False True 4725958.501169577 4672979.765262438 3756185.8472726108 1.0 0.9887898431833398 0.7947987368790971 22.172175530328758 -6.918776204810824 0.8337630439943609 1.0044719952798407 0.7643808747120928 0.9938339623910933 0.007397109617074378 0.09889709020843315 0.10938826561205392 0.006332406985552472 0.018751950442785326 1.2056570644104321e-07 6.918776204810824 -0.24009112056774784 MSYLELMEHPFFTLHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MSYLELMEHPFFTLHK 16 0 P46734-2;P46734;P46734-3 P46734-2 MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 0 11935480.0 544280.0 2857400.0 8533800.0 False True 745515.024613944 2731150.6198417894 6518292.1991279 1.0 3.663441419247161 8.74334115868868 19.507877902354792 -6.960962694549235 0.42164775673242927 0.7794025414910005 11.819525212285628 0.9998042518965934 0.0449405794878977 0.07935901961432613 0.01987388296831967 0.06578468982362247 0.4226725916437895 1.0940503400385197e-07 6.960962694549235 11.040122670794627 MSYLELMEHPFFTLHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MSYLELMEHPFFTLHK 16 0 P46734-2;P46734;P46734-3 P46734-2 MAP2K3 Dual specificity mitogen-activated protein kinase kinase 3 0 12723600.0 4880900.0 3306800.0 4535900.0 False True 4058684.6105324267 3288985.6120515913 5484335.718368001 1.0 0.8103575240895929 1.351259396735573 21.952580805763034 -6.811985822061912 1.4062538332356531 0.8968856913260463 1.3611499431268397 0.8649192517449625 0.08235829439111035 0.20411237514155106 0.7951728799598219 0.04604628081868843 0.1064176909490714 1.5417507839836307e-07 6.811985822061912 0.46426425180079334 MTATGSGENSTVAEHLIAQHSAIK(ub)MLHSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MTATGSGENSTVAEHLIAQHSAIKMLHSR 29 1 Q7L5N1;E7EM64;H7C3T0 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 82689700.0 6484700.0 33169000.0 43036000.0 True False 9837763.995072516 27249732.799420174 34529915.73665116 1.0 2.7699112128598395 3.5099353627456717 23.229899014990973 -9.342691995292423 0.27497490968140037 2.3781030863877215e-18 3.8886366029682393 0.998888504870696 0.035107323898497814 0.7452883106276307 0.1055051660400814 0.9785463149046209 0.2856167010945609 4.5426366943177304e-10 9.342691995292423 3.8886366029682393 MTATGSGENSTVAEHLIAQHSAIK(ub)MLHSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MTATGSGENSTVAEHLIAQHSAIKMLHSR 29 1 Q7L5N1;E7EM64;H7C3T0 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 60880300.0 6484700.0 23847600.0 30548000.0 True False 8394571.982547177 22520460.096274808 24988577.448949248 1.0 2.6827407213966605 2.976754205086574 23.001025337083423 -10.223799622070128 0.3889312166458937 2.4009330869657905e-20 3.0114815386763114 0.9990622271131382 0.026668497191886204 1.6035635871461937 0.17907708122931407 1.7966152202984158 0.07712106708956287 5.97310814601153e-11 10.223799622070128 3.0114815386763114 MTDQEAIQDLWQWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MTDQEAIQDLWQWR 14 0 P06748-2;P06748 P06748-2 NPM1 Nucleophosmin 0 4591020.0 657390.0 3164400.0 769230.0 False True 861844.6561738156 2692283.854734592 689637.4585751911 1.0 3.1238620967809494 0.800187659846795 19.71706832755138 -6.666226733354994 1.9506004683033369 2.360002021008153 0.8096843267643807 0.2625266102814148 0.9029575815535547 0.46982571189421574 3.4425672971948327 0.373143982140467 1.0019324570751846 2.1566182034001805e-07 6.666226733354994 -1.5503176942437724 MTDQEAIQDLWQWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MTDQEAIQDLWQWR 14 0 P06748-2;P06748 P06748-2 NPM1 Nucleophosmin 0 18216400.0 8334400.0 2590700.0 7291300.0 False True 8069829.034019912 3625180.020322023 5381489.79568867 1.0 0.4492263720878573 0.6668654035918193 22.94410667846733 -10.215100498525105 5.476243180797453 1.0000222370225558 0.5580458878398026 0.8461109280888457 0.08885076254983694 2.4123699944947863e-05 3.457633425179192e-06 0.08603370324729376 0.028676460304426308 6.093958628163553e-11 10.215100498525105 -0.4419763491827532 MTDQEAIQDLWQWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MTDQEAIQDLWQWR 14 0 P06748-2;P06748 P06748-2 NPM1 Nucleophosmin 0 4207890.0 657390.0 1945600.0 1604900.0 False True 900444.8482967605 1859636.9587611747 1225855.6739530328 1.0 2.0652424879533458 1.3613889582152692 19.780278389074272 -10.200313957440764 4.91612491423001 0.9999164547296063 1.7133157230855862 0.5779563922333378 0.2873470002569641 0.0002631526980350051 4.280566089740428e-05 0.27825486736305954 0.09274084554752338 6.305013815880528e-11 10.200313957440764 0.7133992683559799 MTGHQALINQVLFSPDSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MTGHQALINQVLFSPDSR 18 0 Q9NVX2;A0A0A0MRH0;K7EN33;Q9NVX2-2 Q9NVX2 NLE1 Notchless protein homolog 1 0 9437900.0 2785300.0 2723300.0 3929300.0 False True 3651555.2728835694 2316994.2553402577 3522733.728507077 1.0 0.6345225752287649 0.9647214584609685 21.80007963785694 -10.338383190853657 8.133198530721147 1.000000833276475 0.7996220180254668 0.3293122629943842 0.13480312959262383 2.0366890763923678e-06 1.6572239442843327e-07 0.13052311158981283 0.04350752299407271 4.5879302755354896e-11 10.338383190853657 -0.2003788152510081 MTGHQALINQVLFSPDSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MTGHQALINQVLFSPDSR 18 0 Q9NVX2;A0A0A0MRH0;K7EN33;Q9NVX2-2 Q9NVX2 NLE1 Notchless protein homolog 1 0 8994900.0 2785300.0 2372000.0 3837600.0 False True 3815100.6799022923 2267197.1968449405 2931237.917852919 1.0 0.594269296427324 0.7683251803273486 21.86328969937983 -10.223984934522802 5.433757747422472 1.0000193512022757 0.6812972383773058 0.8171933965693329 0.0710580170474688 1.6659031257299474e-05 2.379126212130615e-06 0.06880580301949284 0.022933876386598613 5.970559978244413e-11 10.223984934522802 -0.31872211282496987 MTGSEFDFEEMK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 MTGSEFDFEEMKR 13 1 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 1 5683500.0 1653500.0 2014200.0 2015800.0 True False 2167754.512516776 1713689.2112901057 1807224.3529189823 1.0 0.7905365673996463 0.8336849687009918 21.047769957184073 -10.569973988061376 6.369325421659963 1.0003427096088588 0.8121107680503193 0.9619512823679459 0.01761526106752305 8.587981615516566e-05 5.7981691892152545e-06 0.017086582542176786 0.005685301062801057 2.6916960174301003e-11 10.569973988061376 -0.1882319415585395 MTGSEFDFEEMK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MTGSEFDFEEMKR 13 1 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 1 5996200.0 1653500.0 2264400.0 2078300.0 True False 2264843.634157338 2164351.320630557 1587448.3439320745 1.0 0.9556294695089753 0.700908583705693 21.110980018706965 -6.936776724098138 0.6888963127208235 1.0030803215228226 0.6382767515181427 0.9977105097661516 0.0063057591988846685 0.08926839523693174 0.06153940003182023 0.0059974878275496045 0.022252435720074563 1.1567067659081729e-07 6.936776724098138 -0.3648035700046799 MTGSEFDFEEMK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MTGSEFDFEEMKR 13 1 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 1 4792800.0 0.0 2410600.0 2382200.0 True False 0.0 2397613.6193333613 2880307.005951685 0.0 MTGTLETQFTCPFCNHEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MTGTLETQFTCPFCNHEK 18 0 K7EN05;K7EPC8;A0A024R7E8;K7EQ44;K7EMV4;P60002 K7EN05 ELOF1 Transcription elongation factor 1 homolog 0 8298100.0 1916800.0 3996400.0 2384900.0 False True 2512943.3623176026 3400152.6978451894 2138133.425576187 1.0 1.3530558423367502 0.8508482354350634 21.26094672489438 -6.717772224877007 1.767237495938716 1.2153064541065433 0.8517240335241882 0.5019789978045397 0.148609759742735 0.3596886531268127 2.1941535523857474 0.0668000128909439 0.16813997459374772 1.9152601612178364e-07 6.717772224877007 -0.363582420582355 MTGTLETQFTCPFCNHEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MTGTLETQFTCPFCNHEK 18 0 K7EN05;K7EPC8;A0A024R7E8;K7EQ44;K7EMV4;P60002 K7EN05 ELOF1 Transcription elongation factor 1 homolog 0 8285000.0 1916800.0 2828100.0 3540100.0 False True 2625492.7595722927 2703145.1907239356 2704001.2906480953 1.0 1.0295763265270985 1.0299023986219609 21.324156786417273 MTHNLLLNYGLYR ddPTM_RPMI8226_Bortezomib_1h_R1 2 MTHNLLLNYGLYR 13 0 Q92769-3;Q92769;H3BM24;E5RJ04;E5RGV4;E5RHE7;E5RH52;E5RG37;E5RFP9;E5RFI6;E5RK19;Q13547;Q5TEE2 Q92769-3;Q13547 HDAC2;HDAC1 Histone deacetylase 2;Histone deacetylase 1 0 151089100.0 56742500.0 66680400.0 27666200.0 False True 74389966.99515171 56731944.23816351 24803567.016929857 1.0 0.7626289744403429 0.3334262403765605 26.148604721803025 -6.96196813482479 0.406748498578827 1.0219074610333778 0.058303675291058066 0.9998363681407426 0.003528738847970566 0.07900543588855859 0.01858785171331886 0.005522978514204646 0.03587384851584977 1.0915204208498655e-07 6.96196813482479 -0.9636037857423198 down MTHNLLLNYGLYR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MTHNLLLNYGLYR 13 0 Q92769-3;Q92769;H3BM24;E5RJ04;E5RGV4;E5RHE7;E5RH52;E5RG37;E5RFP9;E5RFI6;E5RK19;Q13547;Q5TEE2 Q92769-3;Q13547 HDAC2;HDAC1 Histone deacetylase 2;Histone deacetylase 1 0 220424000.0 98037000.0 35226000.0 87161000.0 False True 94924869.09774077 49291925.50116322 64330919.32604883 1.0 0.5192730416136689 0.677703534779801 26.50028276856767 -10.407022416368102 5.285331711015159 1.000294859409296 0.5984882881967262 0.8954371336573752 0.0646789779924513 0.00022488742343011405 2.5230816144682205e-05 0.06267032582634284 0.020875050384535493 3.9172165763952195e-11 10.407022416368102 -0.4018065712125698 MTHNLLLNYGLYR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MTHNLLLNYGLYR 13 0 Q92769-3;Q92769;H3BM24;E5RJ04;E5RGV4;E5RHE7;E5RH52;E5RG37;E5RFP9;E5RFI6;E5RK19;Q13547;Q5TEE2 Q92769-3;Q13547 HDAC2;HDAC1 Histone deacetylase 2;Histone deacetylase 1 0 229115000.0 61122000.0 79456000.0 88537000.0 False True 92726542.61674738 65276456.00743854 71037623.14285435 1.0 0.7039673233287244 0.7660980463432507 26.46647902809398 -10.798802551818603 7.110855698085993 1.0098289309559165 0.7350326848359876 0.9603959315733346 0.025364761455964183 0.003995734525180807 0.00011305676435477062 0.024828601133090676 0.008186441558289426 1.5892691316600874e-11 10.798802551818603 -0.2747962461199289 MTHNLLLNYGLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MTHNLLLNYGLYR 13 0 Q92769-3;Q92769;H3BM24;E5RJ04;E5RGV4;E5RHE7;E5RH52;E5RG37;E5RFP9;E5RFI6;E5RK19;Q13547;Q5TEE2 Q92769-3;Q13547 HDAC2;HDAC1 Histone deacetylase 2;Histone deacetylase 1 0 191175300.0 56742500.0 53008800.0 81424000.0 False True 77721735.65840518 50666695.93933972 62193328.17991881 1.0 0.6518986678581771 0.8002050861713217 26.211814783325917 -10.175519227617556 5.2466447019713955 1.0000129392958903 0.7260518777588816 0.8198008063139517 0.060545841741590785 9.164264781548887e-06 1.4401751811613543e-06 0.05862602611555089 0.019541086395545474 6.675453459243916e-11 10.175519227617556 -0.2739610615370087 MTHNLLLNYGLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MTHNLLLNYGLYR 13 0 Q92769-3;Q92769;H3BM24;E5RJ04;E5RGV4;E5RHE7;E5RH52;E5RG37;E5RFP9;E5RFI6;E5RK19;Q13547;Q5TEE2 Q92769-3;Q13547 HDAC2;HDAC1 Histone deacetylase 2;Histone deacetylase 1 0 170555000.0 98037000.0 37761700.0 34756300.0 False True 81522109.27549599 37558270.22698938 42023681.63502577 1.0 0.46071268960994227 0.5154881541768117 26.280688044001945 -10.869845686082689 11.313015222956334 1.0172483293625874 0.4881004218933788 0.991485672887868 0.022361989768788348 0.008367328077913868 9.626450675240989e-05 0.01862279414535245 0.007217301163548153 1.3494422824971176e-11 10.869845686082689 -0.5291479074692085 MTHNLLLNYGLYR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MTHNLLLNYGLYR 13 0 Q92769-3;Q92769;H3BM24;E5RJ04;E5RGV4;E5RHE7;E5RH52;E5RG37;E5RFP9;E5RFI6;E5RK19;Q13547;Q5TEE2 Q92769-3;Q13547 HDAC2;HDAC1 Histone deacetylase 2;Histone deacetylase 1 0 350547000.0 61122000.0 145619000.0 143806000.0 False True 79123633.89474426 137515174.64061123 117634783.5741653 1.0 1.7379785011333457 1.4867211954730395 26.237605350186428 -10.331040922110082 5.3669413602772815 0.9998426975557011 1.6123498483032146 0.8878867351085542 0.10257536550245346 0.00019311554735180504 2.407071201271968e-05 0.09934330330613764 0.033106056860167266 4.66615410640144e-11 10.331040922110082 0.6125071507475135 MTIGHLIECLQGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MTIGHLIECLQGK 13 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 7307100.0 1886800.0 2894700.0 2525600.0 False True 2473613.07179719 2462822.0434522275 2264275.139265893 1.0 0.995637543936036 0.9153715935131264 21.238188417635193 -6.918123675263851 0.8385218332960991 1.0018936100783566 0.9029704448210492 0.993643672483265 0.0031018972505496662 0.09928852454484861 0.11142673365799277 0.00264637878699555 0.00779042674835964 1.207469931525753e-07 6.918123675263851 -0.09892316525730749 MTIGHLIECLQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MTIGHLIECLQGK 13 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 5416300.0 2642600.0 1552000.0 1221700.0 False True 2558712.1094861063 2171721.693573082 901700.1197856141 1.0 0.8487557805044554 0.35240389743053674 21.28698640267985 -6.949416936620418 0.5652097329447966 1.0063231900091627 0.17090197245626462 0.9991547202041164 0.008042089833825396 0.08372075029403596 0.03693804245109985 0.008567406482073124 0.04130860097891405 1.1235258352385823e-07 6.949416936620418 -0.8354212175528981 down MTIGHLIECLQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MTIGHLIECLQGK 13 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 18657400.0 1886800.0 7778700.0 8991900.0 False True 2584400.948852777 7435011.313278969 6868198.413993557 1.0 2.8768799657728774 2.6575591597125707 21.301398479158085 -10.324842727053479 8.307122029971227 0.9999956481225766 2.7672195627427243 0.9885803736203626 0.08953734413727665 7.21645311329068e-06 5.864325242432428e-07 0.08669437451877086 0.02889805355894292 4.7332263430997774e-11 10.324842727053479 1.7672239146201476 MTISVALPQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MTISVALPQLK 11 0 Q02040;X6RAJ1;Q02040-2;Q02040-3 Q02040 AKAP17A A-kinase anchor protein 17A 0 14006700.0 4141400.0 4264200.0 5601100.0 False True 6282806.576895349 3503220.1936533316 4494040.129950659 1.0 0.5575884202031967 0.7152918166345001 22.582977735139647 -10.309584065611784 4.731910458541269 1.0001966027429123 0.6364401184183387 0.8763313044881712 0.06438214199517434 0.00013360599492424734 1.949399021982064e-05 0.06237116005611043 0.02077924697812455 4.902481171492194e-11 10.309584065611784 -0.36375648432457364 MTISVALPQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MTISVALPQLK 11 0 Q02040;X6RAJ1;Q02040-2;Q02040-3 Q02040 AKAP17A A-kinase anchor protein 17A 0 13364300.0 4141400.0 5516800.0 3706100.0 False True 5361123.939198551 5209785.2303430475 3031627.827797266 1.0 0.9717710855835713 0.5654836303319025 22.354104057232096 -6.920939796333318 0.81774453399726 1.0086646959432937 0.49853269276072193 0.9944375609338179 0.014805534463346395 0.09762218717119471 0.10277820286280606 0.012820305010199609 0.03875371878434206 1.1996655941449808e-07 6.920939796333318 -0.5101320031825718 MTLQLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MTLQLIK 7 0 A8MV53;A0A0A6YYI3;A0A0B4J1V8;Q9NQ55-2;Q9NQ55;Q9NQ55-3;H7C446 A8MV53 PPAN;PPAN-P2RY11 Suppressor of SWI4 1 homolog 0 10044400.0 2399300.0 1612900.0 6032200.0 False True 3145505.5348542486 1372261.6070349596 5408045.808948258 1.0 0.43626106895359357 1.7192930513151512 21.58486047005868 -6.787282917656244 1.5072933380689324 0.683812983635845 1.7319135826330974 0.7923715124536643 0.23925811616024134 0.2394218319563526 1.0746434756267704 0.124965787987305 0.2931498104923408 1.6319884557428545e-07 6.787282917656244 1.0481005989972525 MTLQLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MTLQLIK 7 0 A8MV53;A0A0A6YYI3;A0A0B4J1V8;Q9NQ55-2;Q9NQ55;Q9NQ55-3;H7C446 A8MV53 PPAN;PPAN-P2RY11 Suppressor of SWI4 1 homolog 0 7010200.0 2399300.0 2253700.0 2357200.0 False True 3286386.0486445124 2154124.082010721 1800477.9080578766 1.0 0.6554689711207851 0.5478595275806059 21.64807053158157 -13.999999999999998 0.16291889074516042 2.70765318424501 0.44540860161349993 0.9995289964497291 0.0041852975802831 12.030410725794663 0.12764626775778348 6.490805804623517 0.0937289393422878 1.0000000000000041e-14 13.999999999999998 -2.26224458263151 MTMLLLYHSTMSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MTMLLLYHSTMSSK 14 0 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4;Q14980-5;F5H4J1;F5H6Y5;F5H763;F5H2F3;F5H3L6;F5H0Z7;F5GZW1 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 0 19923200.0 0.0 3041200.0 16882000.0 False True 0.0 2498474.098995947 13545265.300356558 0.0 MTMLLLYHSTMSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MTMLLLYHSTMSSK 14 0 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4;Q14980-5;F5H4J1;F5H6Y5;F5H763;F5H2F3;F5H3L6;F5H0Z7;F5GZW1 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 0 9566700.0 0.0 0.0 9566700.0 False True 0.0 0.0 7825658.762631366 0.0 MTNGFSGADLTEICQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MTNGFSGADLTEICQR 16 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 17002300.0 2099200.0 6751600.0 8151500.0 False True 2752071.5286817187 5744287.597530678 7308060.974709349 1.0 2.0872595561795855 2.655476392435924 21.39208653672368 -9.243930181060893 0.19817955804749313 1.0072123369721314e-19 3.2398693431142633 0.9995360353429351 0.014794183315780899 0.68078372825099 0.07250477569240617 0.7464439037988843 0.3228534541109731 5.702559415657754e-10 9.243930181060893 3.2398693431142633 MTNGFSGADLTEICQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MTNGFSGADLTEICQR 16 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 16467300.0 2099200.0 7032200.0 7335900.0 False True 2875330.968746955 6721494.151624362 5603311.507602997 1.0 2.337641900943853 1.9487535760256751 21.455296598246573 -10.16759475570688 5.160209948083296 0.999942093420509 2.143197738485634 0.9201411902041547 0.15876299383224812 0.00010577293448805541 1.7062671434948748e-05 0.15372931937394493 0.05124053592508933 6.79837699738735e-11 10.16759475570688 1.1432556450651252 MTNTNLAVVFGPNLLWAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MTNTNLAVVFGPNLLWAK 18 0 Q07960 Q07960 ARHGAP1 Rho GTPase-activating protein 1 0 135585000.0 31861000.0 57080000.0 46644000.0 False True 48335466.35110416 46893628.031924464 37424792.95520854 1.0 0.9701701787936352 0.7742718914380272 25.526578825368148 -6.9339544513203295 0.7135828091332412 1.0025867995550262 0.7296804987125936 0.9972600113113024 0.0052408556718740494 0.09063585551095245 0.06799728120863968 0.004892420631754364 0.017356160609436098 1.1642481290145815e-07 6.9339544513203295 -0.2729063008424326 MTNTNLAVVFGPNLLWAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MTNTNLAVVFGPNLLWAK 18 0 Q07960 Q07960 ARHGAP1 Rho GTPase-activating protein 1 0 88119000.0 31861000.0 24568000.0 31690000.0 False True 41244692.574203186 23200769.202992324 25922745.166858796 1.0 0.5625152657218113 0.6285110531548095 25.297705147460597 -10.578304080403065 6.406498882674932 1.0008040998095613 0.5955131594383428 0.9804251093466593 0.026942667397337992 0.00031000905212481047 2.0405735901658172e-05 0.026135297811217945 0.008695708511024641 2.6405592668868952e-11 10.578304080403065 -0.4052909403712185 MTPGNLGIVFGPTLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MTPGNLGIVFGPTLLR 16 0 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4;K7ES92 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 0 1648970.0 428610.0 742620.0 477740.0 False True 561911.8606651437 631823.9907100871 428308.0476056727 1.0 1.124418320628056 0.7622335059784605 19.099984327029713 -6.81396070940008 1.397688331899181 1.0674985193395028 0.7552990361956842 0.8699371167056481 0.05418852213118493 0.20145628460661547 0.774846749551811 0.030477479709708533 0.0703871965770866 1.5347558258009574e-07 6.81396070940008 -0.3121994831438186 MTPGNLGIVFGPTLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MTPGNLGIVFGPTLLR 16 0 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4;K7ES92 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 0 2541570.0 428610.0 731960.0 1381000.0 False True 587078.6997497288 699619.5869319641 1054836.2425877843 1.0 1.1916964237166354 1.7967544096514831 19.163194388552604 -6.950303362371206 0.555503649458714 0.9918924444542161 2.0252527645052667 0.9992248721659461 0.00945350647053437 0.08336416792302662 0.035460062595456886 0.010189552832680335 0.0502490269113032 1.1212349782491919e-07 6.950303362371206 1.0333603200510506 MTPGNLGIVFGPTLLRPR ddPTM_RPMI8226_Bortezomib_1h_R1 2 MTPGNLGIVFGPTLLRPR 18 1 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4;K7ES92 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 0 20685400.0 5533600.0 8179300.0 6972500.0 False True 7254603.18745862 6958980.32266169 6251052.584942761 1.0 0.9592503053360676 0.8616670579238923 22.790465273189994 -6.9563776074949555 0.48379714977913246 1.002260591966672 0.8145620996896242 0.999611333072343 0.0011442467007932537 0.08102151084884382 0.026113015391923358 0.0013866676928118988 0.008048913356222381 1.1056620222197052e-07 6.9563776074949555 -0.18769849227704782 MTPGNLGIVFGPTLLRPR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MTPGNLGIVFGPTLLRPR 18 1 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4;K7ES92 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 0 23596400.0 9812400.0 6823700.0 6960300.0 False True 9500910.733036194 9548438.995125407 5137188.625475814 1.0 1.0050024953843582 0.5407048618626615 23.179634382458165 -6.9044642400866145 0.9326041148668827 1.0170113000807661 0.4872966037954536 0.9886596720536825 0.023183349196806136 0.10819373038206768 0.15946315518937523 0.018475630828013897 0.049242344225957475 1.2460508331758056e-07 6.9044642400866145 -0.5297146962853125 MTPGNLGIVFGPTLLRPR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MTPGNLGIVFGPTLLRPR 18 1 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4;K7ES92 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 0 30715630.0 5533600.0 10973530.0 14208500.0 False True 7579521.459917172 10488683.159988964 10852744.93324298 1.0 1.3838186507494343 1.431850940806173 22.853675334712886 -12.078223357509557 0.32987874520220095 9.111454004275704e-16 1.4410873943166982 0.9995662080238055 0.004024997799271444 5.562360665367228 0.17669085530433823 3.8218332759470677 0.015390572171622884 8.351733783644116e-13 12.078223357509557 1.4410873943166973 MTPGNLGIVFGPTLLRPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MTPGNLGIVFGPTLLRPR 18 1 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4;K7ES92 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 0 14335200.0 8581900.0 2312800.0 3440500.0 False True 7136230.092632152 2300340.4873451423 4159892.642925352 1.0 0.32234673735088 0.5829258010080505 22.766730701979775 -10.323144096207697 5.751319825171423 1.0000700585652003 0.452636269179638 0.8547181974815559 0.10638095726872371 9.557618996551455e-05 1.1248031557825292e-05 0.10301601285851818 0.034334306321279415 4.7517753883276534e-11 10.323144096207697 -0.5474337893855623 MTSLSSCFAQLCHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MTSLSSCFAQLCHK 14 0 F5H1Y4;Q9HD26-3;Q9HD26-2;Q9HD26 F5H1Y4 GOPC Golgi-associated PDZ and coiled-coil motif-containing protein 0 4822900.0 1627100.0 1286500.0 1909300.0 False True 2133143.856858813 1094559.214737722 1711743.951298847 1.0 0.5131202057556158 0.802451248562062 21.024549832038975 -10.285874436919762 5.838774560753845 1.0000231568748184 0.6577857271588384 0.6509944269176491 0.11811890360386472 3.5608346056890854e-05 4.355137758938165e-06 0.11437586460850217 0.03812271221083638 5.177565039060343e-11 10.285874436919762 -0.3422374297159799 MTSLSSCFAQLCHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MTSLSSCFAQLCHK 14 0 F5H1Y4;Q9HD26-3;Q9HD26-2;Q9HD26 F5H1Y4 GOPC Golgi-associated PDZ and coiled-coil motif-containing protein 0 4652900.0 1627100.0 1046100.0 1979700.0 False True 2228682.8407241646 999879.8430099027 1512135.6332013307 1.0 0.448641603344966 0.6784884800880835 21.087759893561866 -10.285275491866166 5.676525919438031 1.0000382619706707 0.5635650417165221 0.8278027264995549 0.09383459449885495 4.544154344002698e-05 5.721394130594137e-06 0.09086289746043516 0.030284985149346508 5.184710458733303e-11 10.285275491866166 -0.4364732202541486 MTTTSSVEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MTTTSSVEGK 10 0 P00374;B4DM58;C9JJ68;Q86XF0 P00374 DHFR;DHFRL1 Dihydrofolate reductase;Dihydrofolate reductase, mitochondrial 0 3091700.0 1212000.0 471500.0 1408200.0 False True 1173525.7234152588 659772.4088400174 1039350.1749055437 1.0 0.5622138447207715 0.8856645867810804 20.162418035076943 -10.564316626524276 5.726774727770634 1.0008829664151226 0.7239392157509261 0.49270815343655594 0.13204821249538923 0.0014931949095965832 0.00011359957115453187 0.1282466566795265 0.04261837732425837 2.7269889206772112e-11 10.564316626524276 -0.2769437506641965 MTTTSSVEGK(ub)QNLVIMGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MTTTSSVEGKQNLVIMGK 18 1 P00374;B4DM58 P00374 DHFR Dihydrofolate reductase 1 10221400.0 2135700.0 2093300.0 5992400.0 True False 2067903.372523078 2929165.6064152927 4422810.671853407 1.0 1.4164905601180855 2.138789815143574 20.97973734335289 -6.962734157581224 0.3950151620508541 0.9580440801388722 2.6233990585568434 0.9998585516010935 0.005595316909386398 0.07873850183487074 0.01762552248934542 0.009304631234631999 0.06063326526149192 1.0895968584896704e-07 6.962734157581224 1.6653549784179713 up MTTTSSVEGK(ub)QNLVIMGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MTTTSSVEGKQNLVIMGK 18 1 P00374;B4DM58 P00374 DHFR Dihydrofolate reductase 1 7273100.0 2135700.0 2600400.0 2537000.0 True False 1775929.1775521163 2586391.1290610144 3067474.970237354 1.0 1.456359387386164 1.7272507310598177 20.760142618787167 -9.67209463751163 0.11034203166482512 4.435841358495796e-17 2.4025701397772283 0.9999162146987826 0.0027469378427262964 1.1779262884656567 0.046859430971511275 0.6814610386882723 0.3381513823079933 2.1276753517616787e-10 9.67209463751163 2.4025701397772283 MTVCLETEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MTVCLETEK 9 0 P53004 P53004 BLVRA Biliverdin reductase A 0 14980300.0 6638400.0 8341900.0 0.0 False True 8703006.686357053 7097321.036471513 0.0 1.0 0.8155021927763616 0.0 23.05308247397725 -7.2270614889695395 0.8705352496559925 0.9897885840994115 4.4009810287742433e-16 0.9890714668940255 0.045422079114434605 0.0958173353703945 0.13902215422732245 0.038390517829010914 0.06748872692946288 5.928413820297027e-08 7.2270614889695395 -0.9897885840994111 down MTVCLETEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MTVCLETEK 9 0 P53004 P53004 BLVRA Biliverdin reductase A 0 15088500.0 6638400.0 8450100.0 0.0 False True 9092795.876014573 8076746.641256065 0.0 1.0 0.88825777586862 0.0 23.11629253550014 -7.130237400793642 0.9576428516163958 0.996332640077702 1.2540085124531148e-19 0.989688224680279 0.0454319286569319 0.0863081190719834 0.14999997433954637 0.03782575319306078 0.06655208139739284 7.409051255208049e-08 7.130237400793642 -0.996332640077702 down MTVCLETEKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MTVCLETEKK 10 1 P53004 P53004 BLVRA Biliverdin reductase A 0 2931600.0 1019600.0 656200.0 1255800.0 False True 1336705.4738204454 558297.5178475666 1125861.8624842041 1.0 0.41766681500292907 0.8422662168550653 20.3502501901278 -9.885150858229785 6.01938557013168 1.0000000720334454 0.6299665159288291 0.5031441556363929 0.17334197993879213 1.6748825495140175e-07 3.1161529902783634e-08 0.16783768288761008 0.0559458834583641 1.302714183955422e-10 9.885150858229785 -0.3700335561046163 MTVCLETEKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MTVCLETEKK 10 1 P53004 P53004 BLVRA Biliverdin reductase A 0 6088500.0 0.0 4917100.0 1171400.0 False True 0.0 4039605.0875223475 939872.2765571417 0.0 MTVCLETEKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MTVCLETEKK 10 1 P53004 P53004 BLVRA Biliverdin reductase A 0 2831280.0 1019600.0 892720.0 918960.0 False True 1396573.6736539605 853276.6785697349 701920.5745752866 1.0 0.6109786362628784 0.5026018947778095 20.41346025165069 -13.999999999999998 0.17929895416481817 3.014146097035745 0.415886667641041 0.999498999767423 0.0047802172305791485 12.195723504928607 0.1342257343345426 8.556174462049789 0.08140247482300471 1.0000000000000041e-14 13.999999999999998 -2.598259429394704 MVCTGAK(ub)SEEQSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVCTGAKSEEQSR 13 1 Q32MN6;P20226-2;P20226;Q6SJ96 Q32MN6 TBP;TBPL2 TATA-box-binding protein;TATA box-binding protein-like protein 2 1 9212500.0 1441000.0 1517800.0 6253700.0 True False 1865402.9063565745 1433333.0957465721 5115590.768380719 1.0 0.768377218059608 2.7423516661997023 20.83105583960308 -6.877643625405589 1.0928117411031624 0.8604513595942775 2.8760996161355004 0.9717365279905382 0.1481174453393725 0.12973998367694003 0.28504814536604534 0.10461648037907459 0.2515517849290004 1.3254287131164272e-07 6.877643625405589 2.0156482565412226 up MVDPEKPQLGMIDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MVDPEKPQLGMIDR 14 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 9729990.0 3954500.0 949090.0 4826400.0 False True 3828966.5620838567 1328066.5864389646 3562221.0511036166 1.0 0.34684726672467586 0.9303348549392743 21.868523630680585 -10.561768806428658 9.171856012928833 1.0000345625265672 0.6385910608319906 0.33841980356497403 0.23820781039549227 0.0001683686810064756 8.044855274346638e-06 0.23066565326234678 0.07688124021652297 2.7430340179283696e-11 10.561768806428658 -0.3614435016945766 MVDREQLVQK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVDREQLVQKAR 12 2 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 9483700.0 2485300.0 3088100.0 3910300.0 True False 3217269.84258709 2916244.520341931 3198665.523066201 1.0 0.9064345432700488 0.9942173580609797 21.617405513781044 -10.385504749891462 5.567100222444926 1.000018843937948 0.9503259506993047 0.2992054812092355 0.03583718407050448 8.38498580807355e-06 9.255296224115957e-07 0.03471236586102084 0.011566401423335974 4.116188453907849e-11 10.385504749891462 -0.04969289323864334 MVDVVEK(ub)EDVNEAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVDVVEKEDVNEAIR 15 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 34702900.0 7973500.0 8623400.0 18106000.0 True False 10453335.715483828 7336822.333749919 16232564.80501594 1.0 0.7018642214735699 1.5528597996687055 23.317460051711006 -6.81205040863027 1.405926351287673 0.8379099107266764 1.5684524146312175 0.8651108934266601 0.12948822780025077 0.20401505607444684 0.7944017896984763 0.072412662963471 0.1673528730997649 1.5415215179150698e-07 6.81205040863027 0.7305425039045411 MVDVVEK(ub)EDVNEAIR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MVDVVEKEDVNEAIR 15 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 61748100.0 10568000.0 16093300.0 35086800.0 True False 10232524.62463074 22519438.615450818 25896514.49856254 1.0 2.200770527465354 2.5308040242802803 23.28665880285082 -10.261463370096246 0.29187401956579745 1.127384025615369e-16 2.649759687526933 0.9990044451695411 0.020754711777259505 1.74597300286728 0.13698127089601383 1.4823327665755421 0.122041577779132 5.476922932825512e-11 10.261463370096246 2.649759687526933 MVDVVEK(ub)EDVNEAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MVDVVEKEDVNEAIR 15 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 284422000.0 25943000.0 42059000.0 216420000.0 True False 39357427.68735112 34553242.8415331 173644492.13974443 1.0 0.8779344807800533 4.411987834142706 25.230132596677997 -6.8988971743108864 0.9681885357059438 0.8485879112989607 4.774780955701984 0.9860103456620076 0.19373392677024362 0.11222247504598892 0.18202250147460985 0.15037809393715276 0.38914813510411583 1.2621263264296787e-07 6.8988971743108864 3.926193044403023 up MVDVVEK(ub)EDVNEAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MVDVVEKEDVNEAIR 15 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 47557000.0 10590100.0 8994900.0 27972000.0 True False 14505546.156691654 8597475.575843386 21365589.70142327 1.0 0.592702645110486 1.4729255603772604 23.790101280513863 -6.7808765500800385 1.5323759803523649 0.7696417164059912 1.4801009153447402 0.770507768933316 0.17230704711560277 0.24921364778616262 1.155919746826968 0.08855708376795196 0.20881189174438017 1.6562406895140745e-07 6.7808765500800385 0.710459198938749 MVDVVEK(ub)EDVNEAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MVDVVEKEDVNEAIR 15 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 55226500.0 10568000.0 17419800.0 27238700.0 True False 8787760.241780564 17325956.079840414 32934186.23248098 1.0 1.9716009088943751 3.747733816848865 23.067064078285096 -6.961764559153843 0.4098135347643746 0.9123282593599603 4.872899845285488 0.9998301356276438 0.014827520958757263 0.07907678379345487 0.01884642998938306 0.02286975822324971 0.1483026267767234 1.0920321913172028e-07 6.961764559153843 3.960571585925528 MVDVVEK(ub)EDVNEAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MVDVVEKEDVNEAIR 15 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 522273100.0 25943000.0 41418800.0 454911300.0 True False 33583724.91298303 39113807.36994862 372122111.18410975 1.0 1.1646655477108119 11.080429944810922 25.001258918770446 -6.910504621953149 0.8922709369506051 0.6978649545945862 12.37589347395615 0.991111066865596 0.44440617780584935 0.10408582119997072 0.13695666177474977 0.3647512873326244 1.0104605430581448 1.228840108651272e-07 6.910504621953149 11.678028519361565 up MVEINFLCVHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVEINFLCVHK 11 0 P30419;P30419-2;Q5VUC6;O60551 P30419 NMT1;NMT2 Glycylpeptide N-tetradecanoyltransferase 1;Glycylpeptide N-tetradecanoyltransferase;Glycylpeptide N-tetradecanoyltransferase 2 0 11587900.0 5090500.0 3048200.0 3449200.0 False True 6673694.7964721285 2593420.4417905384 3092309.871062681 1.0 0.3886033930052482 0.4633579996342279 22.67005427956567 -10.520718428508056 6.261900725544336 1.0005724174666144 0.4259806963208106 0.9874398491748171 0.03051844036057957 0.00024411043904470672 1.8684067467062938e-05 0.029576794701544586 0.00984978427239574 3.014960116893951e-11 10.520718428508056 -0.5745917211458038 MVEINFLCVHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVEINFLCVHK 11 0 P30419;P30419-2;Q5VUC6;O60551 P30419 NMT1;NMT2 Glycylpeptide N-tetradecanoyltransferase 1;Glycylpeptide N-tetradecanoyltransferase;Glycylpeptide N-tetradecanoyltransferase 2 0 12510200.0 5090500.0 2814500.0 4605200.0 False True 6972595.415589929 2690146.083693115 3517546.6070711543 1.0 0.38581703416754326 0.5044816739554859 22.73326434108856 -10.519602532649476 7.011901751190807 1.0002375069121423 0.4451493540624697 0.9668332213094882 0.04844463633193769 0.0001799447284470887 1.232823829717318e-05 0.04692570325506946 0.01563543914388912 3.0227168525879424e-11 10.519602532649476 -0.5550881528496726 MVFINNIALAQIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVFINNIALAQIK 13 0 P42704 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 18975000.0 5447300.0 9343900.0 4183800.0 False True 7051637.2323359875 8823903.751051774 3422391.3294131854 1.0 1.2513269557584275 0.48533286904202444 22.74952682722508 -6.818295791108463 1.3790652623348565 1.1357033304653692 0.46919025381163576 0.8804619121722242 0.11022843819530577 0.19569944498395456 0.7317545965153625 0.06281600211280237 0.14486242541442323 1.519512261431686e-07 6.818295791108463 -0.6665130766537335 down MVGFIIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVGFIIGR 8 0 Q96I24;Q96I24-2 Q96I24 FUBP3 Far upstream element-binding protein 3 0 10159700.0 3796600.0 3677900.0 2685200.0 False True 4977379.3663267 3129171.6563419155 2407361.2622571955 1.0 0.628678552716234 0.4836603933675695 22.246954919983917 -13.99999999999514 0.13000664376855328 2.7646063651607573 0.280589579499511 0.999645586036602 0.004093472851040571 11.936726295865105 0.11212777872421278 5.382382233687497 0.18059769615585103 1.0000000000111908e-14 13.99999999999514 -2.4840167856612463 MVGFIIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MVGFIIGR 8 0 Q96I24;Q96I24-2 Q96I24 FUBP3 Far upstream element-binding protein 3 0 13563100.0 4412800.0 5058700.0 4091600.0 False True 6694540.218893087 4155935.461196498 3282893.4665880115 1.0 0.6207947559218135 0.4903837095971355 22.674553543962503 -13.999999999999998 0.148934526042912 2.8306736887663764 0.3451330919771916 0.9995698348785088 0.004483171955561771 11.953869409925195 0.1214851194425458 6.3351063587834355 0.13078798800097477 1.0000000000000041e-14 13.999999999999998 -2.4855405967891846 MVGFIIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVGFIIGR 8 0 Q96I24;Q96I24-2 Q96I24 FUBP3 Far upstream element-binding protein 3 0 10401900.0 3796600.0 3017700.0 3587600.0 False True 5200305.619257186 2884368.035800576 2740282.7689413005 1.0 0.5546535621136399 0.5269464853745892 22.31016498150681 -13.999999999999998 0.39498002350716577 8.26919228788462 0.5251252961847742 0.9998305473076656 0.00282170128529876 26.04345593434716 0.20655639186282934 161.9397248763742 0.0071897262158747395 1.0000000000000041e-14 13.999999999999998 -7.744066991699845 MVGFIIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVGFIIGR 8 0 Q96I24;Q96I24-2 Q96I24 FUBP3 Far upstream element-binding protein 3 0 4464280.0 2742100.0 1140300.0 581880.0 False True 2280177.6456270292 1134156.9775681703 703548.4176908588 1.0 0.4973985161828419 0.30854982682605375 21.120714796556886 -13.999999999999998 0.1358297599484834 3.393496144813022 0.06266687777972814 0.9996200708387794 0.005687882548702637 11.932042703403406 0.11514703737087312 7.589439485645419 0.21925811825321373 1.0000000000000041e-14 13.999999999999998 -3.3308292670332937 MVGFIIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVGFIIGR 8 0 Q96I24;Q96I24-2 Q96I24 FUBP3 Far upstream element-binding protein 3 0 22982900.0 4412800.0 10982000.0 7588100.0 False True 5712456.589292363 10370842.04604615 6207143.660480949 1.0 1.8154784870462972 1.0865979571933808 22.445679866054952 -10.26128993636009 4.5313457177827745 0.9997972958393034 1.451038222122906 0.3379969190824613 0.2975642302752865 0.0006096284970549655 9.9383201000458e-05 0.28824348924875914 0.09603844235546653 5.4791105565180036e-11 10.26128993636009 0.45124092628360246 MVHFLTHYADK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVHFLTHYADK 11 0 Q96A33;Q96A33-2;A0A087WYW6 Q96A33 CCDC47 Coiled-coil domain-containing protein 47 0 4043400.0 1211500.0 1446400.0 1385500.0 False True 1588288.2321826902 1230602.7580230404 1242141.7506544546 1.0 0.7747981336686579 0.7820631831713901 20.599041316444307 -10.673295254177207 6.6102935691007225 1.0015342473676423 0.778430658420024 0.9991943049777068 0.002965944039625764 6.749033778087318e-05 3.335612196278742e-06 0.002890076033468334 0.0009572543226044762 2.121801469344756e-11 10.673295254177207 -0.22310358894761828 MVHVVSQAGGPEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVHVVSQAGGPEGK 14 0 A0A087WZ50 A0A087WZ50 SPPL2B 0 3652380.0 918720.0 1735900.0 997760.0 False True 1204450.816897135 1476910.4864852028 894521.3663897443 1.0 1.2262107059630456 0.7426798619259354 20.199944052425415 -6.779488519633756 1.537857304387423 1.1281708606778709 0.7389102934591049 0.7655803237701044 0.09564119632396252 0.25136869999086214 1.1741958839230309 0.048984854968644076 0.11563350972067943 1.6615425992674934e-07 6.779488519633756 -0.389260567218766 MVHVVSQAGGPEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVHVVSQAGGPEGK 14 0 A0A087WZ50 A0A087WZ50 SPPL2B 0 2917100.0 918720.0 1077400.0 920980.0 False True 1258395.6114744663 1029796.9055146448 703463.4921784925 1.0 0.8183411449663499 0.5590161677012223 20.263154113948307 -6.966067030310461 0.3392412357033196 1.0283758901610565 0.34037324347923376 0.9999334796799939 0.0014758918541277106 0.07760071425276628 0.013593454079871002 0.0036692844318821785 0.022458206298538116 1.0812670524246322e-07 6.966067030310461 -0.6880026466818228 MVHVVSQAGGPEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVHVVSQAGGPEGK 14 0 A0A087WZ50 A0A087WZ50 SPPL2B 0 4361580.0 1972400.0 1564800.0 824380.0 False True 1640137.9921354998 1556370.111811517 996754.0464975438 1.0 0.9489263216109548 0.6077257226385846 20.645385769652023 -6.933606224772133 0.7165733675730908 1.0045590526264825 0.5307804407801895 0.997200721634247 0.009213143397826596 0.09080819996890066 0.06882095804329681 0.008581506558157183 0.03028395995188831 1.1651820222727161e-07 6.933606224772133 -0.473778611846293 MVIITGPPEAQFK(ub)AQGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MVIITGPPEAQFKAQGR 17 1 O00425;O00425-2;Q9NZI8;Q9NZI8-2;F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 O00425;F8W930 IGF2BP3;IGF2BP1;IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 3;Insulin-like growth factor 2 mRNA-binding protein 1;Insulin-like growth factor 2 mRNA-binding protein 2 1 96377000.0 12182000.0 17183000.0 67012000.0 True False 18480984.62349425 14116559.398608217 53767048.82759704 1.0 0.7638423864420251 2.909317329296666 24.13953828641956 -6.879599004142344 1.0819814736803353 0.8543786239268655 3.060232747293468 0.9733627866868456 0.1567744656808959 0.12798828749467855 0.2744089452803926 0.11165236084230584 0.26974272218128964 1.3194744828086445e-07 6.879599004142344 2.2058541233666027 up MVIITGPPEAQFK(ub)AQGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVIITGPPEAQFKAQGR 17 1 O00425;O00425-2;Q9NZI8;Q9NZI8-2;F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 O00425;F8W930 IGF2BP3;IGF2BP1;IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 3;Insulin-like growth factor 2 mRNA-binding protein 1;Insulin-like growth factor 2 mRNA-binding protein 2 1 53778000.0 12182000.0 12682000.0 28914000.0 True False 15769839.143119888 11976235.551626049 23651948.68269343 1.0 0.7594392969348122 1.4998218097241893 23.910664608512008 -6.819220241983384 1.375288880084679 0.8702374928120653 1.515710922067151 0.8825737767288164 0.10567251324378092 0.194494888221869 0.7230650463479992 0.06038423479511579 0.1392027056658764 1.5162812269565948e-07 6.819220241983384 0.6454734292550857 MVILLCNLKPAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVILLCNLKPAK 12 1 Q12904;Q12904-2;A0A5F9ZHC5 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 0 118113000.0 40233000.0 33511000.0 44369000.0 False True 52745852.61692617 28511289.424854927 39778121.49750091 1.0 0.5405408768708696 0.7541469049025494 25.652554324017643 -10.017555677143198 4.904397984257196 1.0000053586257414 0.6473438908814031 0.784215255519408 0.08720429579504874 120412459.75889935 10.399384844636039 7286.741070039311 0.02985234994616353 9.603826881274769e-11 10.017555677143198 -0.35266146774433826 MVILLCNLKPAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MVILLCNLKPAK 12 1 Q12904;Q12904-2;A0A5F9ZHC5 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 0 51055500.0 29244700.0 10712300.0 11098500.0 False True 28316343.006239474 14989777.253906514 8191469.902136891 1.0 0.5293684022192956 0.2892841741722054 24.755131620754078 -9.743678010467237 0.17239348220527986 1.6066821265428597 4.704589733895345e-23 0.9996386698694887 0.005611232832212778 1.2107341862536898 0.07352526104246672 0.5215680637106593 0.16864037272368335 1.8043550088440508e-10 9.743678010467237 -1.6066821265428597 MVILLCNLKPAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MVILLCNLKPAK 12 1 Q12904;Q12904-2;A0A5F9ZHC5 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 0 67616200.0 17221200.0 20372000.0 30023000.0 False True 26125819.438361447 16736457.432837507 24088940.890451655 1.0 0.640609856174034 0.9220358024476364 24.63897295235703 -9.99300167160807 6.045549758598156 1.0000001786261108 0.7813228293108128 0.4459955986793682 0.1148916614584529 2.76608074799908e-07 4.606472203285012e-08 0.11124346403204152 0.03708112428721238 1.0162447813168591e-10 9.99300167160807 -0.21867734931529803 MVILLCNLKPAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVILLCNLKPAK 12 1 Q12904;Q12904-2;A0A5F9ZHC5 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 0 118131000.0 40233000.0 32286000.0 45612000.0 False True 55108227.35594325 30859497.76447539 34839385.008627154 1.0 0.5599798658946937 0.632199340828005 25.715764385540535 -10.703032507762138 6.7933455688941535 1.0038804512637831 0.5960896033613685 0.9765841703684937 0.029483477179722134 0.0017430141822003939 7.61948617723816e-05 0.028715656982923398 0.009515751342112523 1.9813787103160065e-11 10.703032507762138 -0.4077908479024146 MVILLCNLKPAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVILLCNLKPAK 12 1 Q12904;Q12904-2;A0A5F9ZHC5 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 0 52316900.0 29244700.0 4008300.0 19063900.0 False True 24318263.8098789 3986706.4923147415 23050073.348485563 1.0 0.16393877965478795 0.9478502876970125 24.535536896188354 -9.795528009145045 11.404613562208004 0.9999921151179344 0.5558945336759002 0.2996875690868027 0.3200305330655648 0.0 0.0 0.3098682311955738 0.10328941039852456 1.6012973718383326e-10 9.795528009145045 -0.44409758144203415 MVILLCNLKPAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVILLCNLKPAK 12 1 Q12904;Q12904-2;A0A5F9ZHC5 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 0 70794900.0 17221200.0 33398000.0 20175700.0 False True 22293182.880602214 31539371.940798514 16503929.620163877 1.0 1.414754102620385 0.7403128440005894 24.41009927444948 -6.740356798258109 1.6857229886655491 1.2466822261859807 0.7399135712153754 0.6063834406816273 0.1742601974346045 0.3171801308873185 1.769943578992345 0.08178027283540691 0.20057706185092153 1.8182064821172908e-07 6.740356798258109 -0.5067686549706053 MVINHLEK(ub)LFVTNDAATILR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MVINHLEKLFVTNDAATILR 20 1 P50990;P50990-2;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 218451800.0 71487000.0 62857000.0 84107800.0 True False 108451005.39974844 51639677.24601745 67483856.46424165 1.0 0.47615674060073976 0.6222520133907231 26.69246818673802 -10.54591900749951 9.57790248480833 1.0000201760536576 0.5492043769957653 0.926979571526912 0.05964314536136243 2.569735853099003e-05 1.2183226995642676e-06 0.05775180081868531 0.019249742391665405 2.8449916265095304e-11 10.54591900749951 -0.45081579905789226 MVINHLEK(ub)LFVTNDAATILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVINHLEKLFVTNDAATILR 20 1 P50990;P50990-2;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 50785100.0 27623800.0 17662700.0 5498600.0 True False 22970413.64183365 17567547.52932857 6648331.837346121 1.0 0.7647902124554955 0.2894302184109649 24.45327350062476 -6.959840231545444 0.43768346301913036 1.0174132621176835 0.018344799363247295 0.999764217501399 0.004538378853061563 0.07975830223083112 0.02134292233587419 0.006249779980320735 0.03940425746584578 1.096881643253931e-07 6.959840231545444 -0.9990684627544362 down MVINHLEK(ub)LFVTNDAATILR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MVINHLEKLFVTNDAATILR 20 1 P50990;P50990-2;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 179828800.0 71487000.0 70205600.0 38136200.0 True False 92541330.7194396 66298596.64431773 31195802.910456263 1.0 0.7164214749117584 0.3371013002291218 26.463594508830468 -6.991417647825028 0.324058636982817 1.0503305944348684 1.2499907021935473e-13 0.999950251763729 0.0019154157830936103 0.07449508424984994 0.012430834068521518 0.005639324985667458 0.032174406416980064 1.0199581491210314e-07 6.991417647825028 -1.0503305944347434 down MVK(ub)VASLLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MVKVASLLVK 10 1 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 1 6201400.0 1426900.0 2302000.0 2472500.0 True False 1381603.84054557 3221200.6047714115 1824878.076589939 1.0 2.331493667171205 1.320840332833273 20.397912567674485 -10.141235029011373 4.595817953030743 0.9999066013989986 1.826167000016499 0.47117484872387483 0.4125974960437397 0.00039489346995040916 7.378962568388339e-05 0.39954056229134194 0.13316526923182676 7.223787649806537e-11 10.141235029011373 0.8262603986175003 MVK(ub)VDPETR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVKVDPETR 9 1 E9PDU5;A0A087X295;Q9NNW5;Q6PKC6;E9PBK6 E9PDU5 WDR6 WD repeat-containing protein 6 1 7570000.0 2087300.0 4229000.0 1253700.0 True False 2736470.5134419543 3598049.684512888 1123979.1503395825 1.0 1.3148505225394271 0.41074045739518406 21.38388488034052 -6.8126073834220975 1.403301946544128 1.1710678584715783 0.393922232345687 0.8666040155760396 0.1368625422098717 0.20325079346804448 0.7883164325958738 0.0766731082177295 0.17718079742504936 1.5395458117170588e-07 6.8126073834220975 -0.7771456261258913 down MVK(ub)VDPETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MVKVDPETR 9 1 E9PDU5;A0A087X295;Q9NNW5;Q6PKC6;E9PBK6 E9PDU5 WDR6 WD repeat-containing protein 6 1 12439000.0 3565000.0 5633100.0 3240900.0 True False 3451831.026382336 7882426.206228434 2392011.0650840625 1.0 2.2835492658774634 0.6929687597109847 21.71893041293524 -6.691961566120296 1.8593171040150147 1.8032298934689293 0.6983187053631239 0.3796135430787838 0.5426389270350407 0.4125035557695754 2.7663291944903503 0.23333575958330194 0.6061532372085016 2.0325368769592852e-07 6.691961566120296 -1.1049111881058054 MVK(ub)VDPETR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MVKVDPETR 9 1 E9PDU5;A0A087X295;Q9NNW5;Q6PKC6;E9PBK6 E9PDU5 WDR6 WD repeat-containing protein 6 1 16360900.0 5158000.0 3693600.0 7509300.0 True False 7825063.1003105845 3034448.22177148 6025083.563556895 1.0 0.38778578305024014 0.7699725211567627 22.8996709551251 -10.128211024033893 5.299098004797921 1.000010109077334 0.5788791521033131 0.6181499540792721 0.15602708247085523 1.863500746446903e-05 3.065640007594915e-06 0.15107619729933447 0.050357524330448565 7.443701959492411e-11 10.128211024033893 -0.4211309569740208 MVK(ub)VDPETR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVKVDPETR 9 1 E9PDU5;A0A087X295;Q9NNW5;Q6PKC6;E9PBK6 E9PDU5 WDR6 WD repeat-containing protein 6 1 6228800.0 2087300.0 2256300.0 1885200.0 True False 2859031.2171615465 2156609.2054136735 1439954.5869127403 1.0 0.7543146757084943 0.5036512292238385 21.447094941863412 -6.970875163739569 0.2363578771507443 1.0941711271732952 0.15657720972880476 0.9999884244803467 0.0006894037253417821 0.07601979802389171 0.008007319720140864 0.00614947615099247 0.024598641241721217 1.0693622190612666e-07 6.970875163739569 -0.9375939174444905 MVK(ub)VDPETR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVKVDPETR 9 1 E9PDU5;A0A087X295;Q9NNW5;Q6PKC6;E9PBK6 E9PDU5 WDR6 WD repeat-containing protein 6 1 11733800.0 3565000.0 6632300.0 1536500.0 True False 2964455.4562781663 6596570.483491517 1857775.0460266809 1.0 2.2252216573270496 0.6266834072653237 21.499335688369516 -6.701906836718718 1.8239576803154893 1.7593866494145467 0.6312504123325182 0.4266650194515371 0.517003344243572 0.3915793176782455 2.5339409843019256 0.22601314993704838 0.579906044879341 1.9865210129553418e-07 6.701906836718718 -1.1281362370820285 MVK(ub)VDPETR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVKVDPETR 9 1 E9PDU5;A0A087X295;Q9NNW5;Q6PKC6;E9PBK6 E9PDU5 WDR6 WD repeat-containing protein 6 1 14202700.0 5158000.0 3035000.0 6009700.0 True False 6677132.679380442 2866099.582020581 4915996.264729288 1.0 0.4292410709272472 0.7362436094628322 22.67079727721755 -10.093794222853191 5.340963833633753 1.000006031037605 0.5827423401947359 0.7112325746370404 0.1253332615263368 9.0007734040287e-06 1.5273474141434245e-06 0.12135516204073497 0.04045113621795191 8.05760135541325e-11 10.093794222853191 -0.4172636908428692 MVLAAAGGVEHQQLLDLAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVLAAAGGVEHQQLLDLAQK 20 0 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 7411500.0 1551700.0 4205100.0 1654700.0 False True 2034293.726684175 3577715.4713514177 1483487.5170031958 1.0 1.7587015210350003 0.7292395869603485 20.95609657075974 -6.709211834755954 1.7981694899217837 1.466777484109416 0.7317175149494569 0.461506465126174 0.31974653772940864 0.3765473465577457 2.372917448455693 0.14153897617516975 0.35989873891611807 1.953386424852439e-07 6.709211834755954 -0.7350599691599592 MVLAAAGGVEHQQLLDLAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MVLAAAGGVEHQQLLDLAQK 20 0 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 13952000.0 3934500.0 2782300.0 7235200.0 False True 3809601.451136415 3893286.899502828 5340084.068652593 1.0 1.021966982488798 1.4017434991945497 21.861208644590132 -6.918785973158757 0.8336855237908344 0.991248240632725 1.4613069786353117 0.9938369166127996 0.01447827796074243 0.09889129789141331 0.10935589092722318 0.012394987752082684 0.036708489267493365 1.2056299465313543e-07 6.918785973158757 0.4700587380025867 MVLAAAGGVEHQQLLDLAQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MVLAAAGGVEHQQLLDLAQK 20 0 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 50761200.0 7848200.0 29845000.0 13068000.0 False True 11906293.180274796 24518926.5699507 10485104.072092138 1.0 2.059324946791274 0.8806354684313379 23.50522098901532 -6.6698349366345 1.9377053062499425 1.6762420815438828 0.8853744971840962 0.278450849797374 0.44999204140406807 0.4614794274331581 3.340287070390617 0.18695717824114527 0.49965626520956036 2.138774824419766e-07 6.6698349366345 -0.7908675843597865 MVLAAAGGVEHQQLLDLAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVLAAAGGVEHQQLLDLAQK 20 0 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 9854500.0 1551700.0 3532900.0 4769900.0 False True 2125405.423115781 3376804.79626201 3643347.8591741347 1.0 1.5887814905975515 1.7141895939237302 21.019306632282632 -11.437768587169188 0.2726106281987958 1.88664625799563e-09 1.7607845986316502 0.9993136360001527 0.008156954746017853 3.7957458869395437 0.14838324856968937 2.300911390568787 0.051240488609011245 3.649483570307893e-12 11.437768587169188 1.760784596745004 MVLAAAGGVEHQQLLDLAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVLAAAGGVEHQQLLDLAQK 20 0 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 10696700.0 3934500.0 2987900.0 3774300.0 False True 3271711.0779036353 2971803.5896482854 4563488.679608529 1.0 0.908333137885905 1.3948324197785236 21.641613920024408 -6.857963569345109 1.195941662249379 0.9505079404901755 1.417495514002703 0.9511193932523524 0.046666665465914914 0.14891686744030963 0.4058836466025482 0.030457913513448013 0.07094466265855165 1.3868721613240138e-07 6.857963569345109 0.4669875735125275 MVLAAAGGVEHQQLLDLAQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVLAAAGGVEHQQLLDLAQK 20 0 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 27466100.0 7848200.0 10376000.0 9241900.0 False True 10159649.611150345 9798566.47876297 7559969.02990194 1.0 0.9644590959130045 0.7441171023855762 23.27634731110777 -6.935145688761762 0.7032694976526437 1.0027983262271851 0.6923212441991544 0.9974564772456719 0.005708102904230358 0.09005255203606531 0.0652262856944947 0.005369942731945526 0.01940417569630575 1.1610590587366906e-07 6.935145688761762 -0.3104770820280307 MVLAGVGVEHEHLVDCAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVLAGVGVEHEHLVDCAR 18 0 Q10713;Q10713-2 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 8310400.0 2356200.0 3048300.0 2905900.0 False True 3089001.0174732553 2593505.522180333 2605225.343361085 1.0 0.8395936121451237 0.843387661131983 21.55870891549315 -10.255365395236561 7.729059343552525 1.0000002784388764 0.841490636638563 0.9995704865712285 0.001548914012821465 7.431928162805992e-09 7.170668181012591e-10 0.001499732181088181 0.0004999098480304088 5.5543674190898206e-11 10.255365395236561 -0.15850964180031335 MVLAGVGVEHEHLVDCAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVLAGVGVEHEHLVDCAR 18 0 Q10713;Q10713-2 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 7285400.0 2356200.0 2202600.0 2726600.0 False True 3227350.8139108075 2105281.8489758237 2082633.2360896831 1.0 0.6523250710463379 0.6453073607966437 21.62191897701604 MVLQLSK(ub)EPSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVLQLSKEPSAR 12 1 Q92600;Q92600-3;Q92600-2;H7C0W0 Q92600 RQCD1 Cell differentiation protein RCD1 homolog 1 5902600.0 1549700.0 2730700.0 1622200.0 True False 2031671.7073161476 2323290.2041852335 1454350.3052411834 1.0 1.1435362297062825 0.715839227373201 20.95423586883045 -6.816196538328708 1.3882020615843806 1.0776765014105822 0.7072392199298652 0.8754134858948694 0.06273116903665775 0.19847624809047615 0.7525550621560997 0.03551896340509336 0.08196193874168674 1.526874920381335e-07 6.816196538328708 -0.3704372814807171 MVLQLSK(ub)EPSAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MVLQLSKEPSAR 12 1 Q92600;Q92600-3;Q92600-2;H7C0W0 Q92600 RQCD1 Cell differentiation protein RCD1 homolog 1 11727100.0 2680200.0 4204500.0 4842400.0 True False 4066059.348866303 3454174.1250915583 3885297.5175006804 1.0 0.849513946729442 0.9555437302173116 21.955199842472933 -10.022610349089819 4.720548103025913 1.0000020829663403 0.9025288384764074 0.529803403142781 0.04328647785876877 59800508.442202255 9.550913857384748 1541.5805346975662 0.014818112722126263 9.492697703387339e-11 10.022610349089819 -0.09747324448993289 MVLQLSK(ub)EPSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVLQLSKEPSAR 12 1 Q92600;Q92600-3;Q92600-2;H7C0W0 Q92600 RQCD1 Cell differentiation protein RCD1 homolog 1 6373700.0 2711600.0 2390800.0 1271300.0 True False 2254815.5442479337 2377920.2858633585 1537122.9521729378 1.0 1.0545963690597515 0.6817067392027522 21.104577987601633 -6.869702113761766 1.135730375319384 1.0308201408442588 0.6599973853262875 0.964381891693876 0.031032671590510364 0.13713765846907908 0.33080613014918403 0.021210115893804848 0.05018783684315344 1.349888464975795e-07 6.869702113761766 -0.3708227555179713 MVLQLSK(ub)EPSAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVLQLSKEPSAR 12 1 Q92600;Q92600-3;Q92600-2;H7C0W0 Q92600 RQCD1 Cell differentiation protein RCD1 homolog 1 14943500.0 2680200.0 6963700.0 5299600.0 True False 3469571.734640448 6576163.973415721 4335127.178488002 1.0 1.8953820460775714 1.2494703986678781 21.726326164565382 -10.021668001589648 5.983634410575705 0.9999991988059288 1.5724262223727774 0.5115290402023465 0.26369232584589164 2.8187782187697768e-06 4.603392156495119e-07 0.25531935422711177 0.08510633221029246 9.513317656877652e-11 10.021668001589648 0.5724270235668486 MVLSGCAIIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVLSGCAIIVR 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 27473400.0 7172400.0 11702000.0 8599000.0 False True 9403085.857620401 9956107.214038743 7709257.967432453 1.0 1.0588127519829211 0.8198646789112061 23.16470286025236 -6.841615656336854 1.2750066673072222 1.0312820112054426 0.8117575550860961 0.9271742657939297 0.027432895439663502 0.16692193214149517 0.5264317317498013 0.016867249824403126 0.03887433671695604 1.4400724555588635e-07 6.841615656336854 -0.21952445611934646 MVLSGCAIIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MVLSGCAIIVR 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 12372400.0 7282000.0 1992700.0 3097700.0 False True 7050836.895965277 2788395.50179322 2286319.4409919777 1.0 0.3954701467266719 0.32426213720817815 22.749363077048507 -13.999999999999998 0.30179400889436714 6.571579316343067 0.307064853039512 0.9996538298792982 0.005640467130311355 16.706224983360887 0.17452081170168102 58.1824511505308 0.025537166339069717 1.0000000000000041e-14 13.999999999999998 -6.264514463303555 MVLSGCAIIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MVLSGCAIIVR 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 188676000.0 27712000.0 80211000.0 80753000.0 False True 42041130.01857437 65896720.35859652 64792134.154702805 1.0 1.5674345653763924 1.5411606235626092 25.325298112062608 -10.046206817507677 4.685357549037532 0.9999815390686002 1.5542975944873796 0.9983177340294425 0.010726291889898074 7426659.48576164 0.5662848901611167 1508.8035678740423 0.0036718950074235896 8.99069329348199e-11 10.046206817507677 0.5543160554187794 MVLSGCAIIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVLSGCAIIVR 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 30982400.0 7172400.0 10583000.0 13227000.0 False True 9824230.106821954 10115408.066698974 10103055.018615944 1.0 1.0296387560868332 1.0283813498627616 23.22791292177525 -10.62958615778256 5.666093775834092 0.9997689271313261 1.0290100529747974 0.998592790395274 0.0005133339413958337 1.510350083178981e-06 9.873633943120871e-08 0.0005009896216415183 0.00016567781717242706 2.346463711836878e-11 10.62958615778256 0.029241125843471272 MVLSGCAIIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVLSGCAIIVR 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 15592400.0 7282000.0 1162100.0 7148300.0 False True 6055305.647298076 1155839.5366412099 8642976.479995145 1.0 0.19088046152665378 1.427339424864822 22.529768352482783 -6.730141843903313 1.722428729108693 0.5131413615794366 1.4266545333741343 0.5599470749174627 0.3401339386794851 0.3360239040686238 1.9530361974817965 0.15647507908481584 0.38826209038562565 1.8614790640514627e-07 6.730141843903313 0.9135131717946977 MVLSGCAIIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVLSGCAIIVR 11 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 115950000.0 27712000.0 51721000.0 36517000.0 False True 35873730.28518622 48842680.88358705 29871280.696061283 1.0 1.3615166445000633 0.8326784100396829 25.096424434155058 -6.722691658112534 1.7497273707678496 1.2193080972583872 0.8333805914248081 0.5251558117782675 0.15207929935637884 0.3501084141706391 2.096215755867226 0.06897588776964018 0.17260313772800687 1.8936876283207825e-07 6.722691658112534 -0.38592750583357904 MVLVGDVK(ub)DR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MVLVGDVKDR 10 1 B1ALA9;P60891;A0A2R8Y7H4;P60891-2;B7ZB02;P11908;P11908-2 B1ALA9;P11908 PRPS1;PRPS2 Ribose-phosphate pyrophosphokinase 1;Ribose-phosphate pyrophosphokinase 2 1 41773000.0 5733800.0 6746200.0 29293000.0 True False 8698593.79692919 5542287.901698815 23503225.71042201 1.0 0.6371475701802944 2.7019569207518583 23.052350764978854 -6.861535899122493 1.1780271017594777 0.802289213088429 2.804881995560081 0.9554759866036548 0.1899293089598196 0.1452233575600138 0.3820944069072687 0.1256735294732679 0.2938701099129078 1.3755111047491413e-07 6.861535899122493 2.002592782471652 up MVLVGDVK(ub)DR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVLVGDVKDR 10 1 B1ALA9;P60891;A0A2R8Y7H4;P60891-2;B7ZB02;P11908;P11908-2 B1ALA9;P11908 PRPS1;PRPS2 Ribose-phosphate pyrophosphokinase 1;Ribose-phosphate pyrophosphokinase 2 1 12508100.0 4867900.0 4533500.0 3106700.0 True False 4047874.5345347794 4509077.135670706 3756296.606242172 1.0 1.1139369803093297 0.9279676467724022 21.948733143148477 -6.740907240415825 1.6832389563218995 1.0677205789297934 0.9278341203726593 0.6090513942380492 0.04787071696904934 0.31618495053137224 1.7593175191146928 0.02249475066789421 0.05514811626376459 1.8159034744330667e-07 6.740907240415825 -0.1398864585571341 MVLVGDVK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVLVGDVKDR 10 1 B1ALA9;P60891;A0A2R8Y7H4;P60891-2;B7ZB02;P11908;P11908-2 B1ALA9;P11908 PRPS1;PRPS2 Ribose-phosphate pyrophosphokinase 1;Ribose-phosphate pyrophosphokinase 2 1 32114000.0 5733800.0 5284200.0 21096000.0 True False 7422517.130095293 4990129.624814881 17256744.463239267 1.0 0.6722961412351521 2.324918105378319 22.823477087071304 -6.85519600899763 1.2098547670694013 0.8240172287484735 2.3978715440304676 0.9475143922776936 0.1636787616647189 0.15183816681101908 0.4251029815342527 0.10570687499589115 0.24555248513885378 1.3957382839558608e-07 6.85519600899763 1.5738543152819942 up MVMTVFACLMGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MVMTVFACLMGK 12 0 P13796;P13796-2;Q14651 P13796;Q14651 LCP1;PLS1 Plastin-2;Plastin-1 0 10505400.0 7849800.0 1389000.0 1266600.0 False True 7600612.395763282 1943634.9435393088 934839.4628144864 1.0 0.25572083436628423 0.12299528171382383 22.857684233240548 -13.999999999999998 0.24251079839229486 5.987035251919057 0.06569305663750274 0.999529198309625 0.008374603127352227 13.713404581091222 0.1558510801498628 33.16804366990494 0.06391162368410054 1.0000000000000041e-14 13.999999999999998 -5.921342195281554 MVMTVFACLMGK ddPTM_RPMI8226_Bortezomib_8h_R1 5 MVMTVFACLMGK 12 0 P13796;P13796-2;Q14651 P13796;Q14651 LCP1;PLS1 Plastin-2;Plastin-1 0 630732300.0 163568500.0 214586800.0 252577000.0 False True 248145372.95912158 176292108.9656793 202655045.24156827 1.0 0.7104388321386146 0.816678718707976 27.886610312782228 -10.381020166132647 5.100663597743925 1.0001646323940439 0.7635587754232754 0.8684910224303817 0.04337225207108574 8.125613909978658e-05 9.860675559571197e-06 0.04202408495226874 0.013998334163225499 4.158912984507801e-11 10.381020166132647 -0.2366058569707684 MVMTVFACLMGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MVMTVFACLMGK 12 0 P13796;P13796-2;Q14651 P13796;Q14651 LCP1;PLS1 Plastin-2;Plastin-1 0 7787210.0 1819450.0 2263060.0 3704700.0 False True 2492149.8337874655 2163070.5262613418 2829726.1606915067 1.0 0.8679536426483625 1.1354558712029794 21.24895937844205 -6.772518416721085 1.5651619770118699 0.9245043644158728 1.1370931119234786 0.7399721058220432 0.05568952395603987 0.2623796796480377 1.2689005434591005 0.02804176296977565 0.06658851280293837 1.688424258535645e-07 6.772518416721085 0.2125887475076058 MVMTVFACLMGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVMTVFACLMGK 12 0 P13796;P13796-2;Q14651 P13796;Q14651 LCP1;PLS1 Plastin-2;Plastin-1 0 14015800.0 7849800.0 1250700.0 4915300.0 False True 6527456.505103053 1243962.2308554875 5943066.504220603 1.0 0.19057380618055125 0.9104720191661816 22.638089508674824 -10.923875851308278 9.792466937540391 1.0807726530002437 0.5505229126734601 0.3420059323897141 0.2938972147593735 0.14180243696993805 0.0011023347443566123 0.07785938821931881 0.09485491818831646 1.1915825886317698e-11 10.923875851308278 -0.5302497403267836 MVMTVFACLMGK ddPTM_RPMI8226_Carfilzomib_8h_R1 4 MVMTVFACLMGK 12 0 P13796;P13796-2;Q14651 P13796;Q14651 LCP1;PLS1 Plastin-2;Plastin-1 0 424732900.0 152476000.0 131996900.0 140260000.0 False True 197383187.7513013 124651156.48039968 114734119.18913275 1.0 0.6315186105792229 0.581276047348548 27.556423871584393 -13.999999999999998 0.2807668079763108 4.01581025549515 0.5662648116229549 0.9996068753273595 0.0037012972583086593 15.440062568558762 0.1678667478457994 26.749627573777964 0.01980277680396606 1.0000000000000041e-14 13.999999999999998 -3.4495454438721946 MVMTVFACLMGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MVMTVFACLMGR 12 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 62348000.0 14113000.0 21439000.0 26796000.0 False True 21410452.798503883 17613042.94632843 21499758.854895994 1.0 0.8226375739031168 1.004171142816669 24.35181197106286 -11.03939933847616 9.463003933183414 1.2043300000869592 0.9134043583557947 0.23277636599462448 0.0741107691707616 0.05293971391861625 0.00022041537174150976 0.011890635373299974 0.023919147897748478 9.132730907749658e-12 11.03939933847616 -0.29092564173116453 MVMTVFACLMGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MVMTVFACLMGR 12 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 43582000.0 14113000.0 13966000.0 15503000.0 False True 18269556.708820466 13188779.82289932 12681613.074213054 1.0 0.7218992793914825 0.6941390684148578 24.12293829315531 -13.999999999999998 0.3257398390262858 3.95081779952486 0.6889741073283999 0.9997059303206189 0.002368312970524881 18.46957150599446 0.18228410291617095 37.25508228879399 0.00903973684522005 1.0000000000000041e-14 13.999999999999998 -3.26184369219646 MVNHFIAEFK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MVNHFIAEFK 10 0 A8K7Q2;P11142;E9PKE3;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 667770700.0 233060100.0 264200200.0 170510400.0 False True 305544048.05721927 224782560.00431374 152867619.45925048 1.0 0.7356797209226562 0.5003128695559566 28.186805136959176 -6.972496367518033 0.18928818789265767 1.1610099631562996 0.06855751449967354 0.9999958716236941 0.00041467988566462865 0.07550068765946598 0.0060336128701887 0.008360142447724912 0.02570838986552451 1.0653777745552919e-07 6.972496367518033 -1.092452448656626 MVNHFIAEFK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MVNHFIAEFK 10 0 A8K7Q2;P11142;E9PKE3;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 565375900.0 193304500.0 120192600.0 251878800.0 False True 187168154.4570338 168186131.97612894 185904186.0779707 1.0 0.8985830547083672 0.9932468833561467 27.47975974896045 -10.399362052320106 5.602854034502189 1.0000233232414366 0.9459149690628501 0.3032504521689562 0.03864634621422088 1.1264098778336262e-05 1.207556201234893e-06 0.03743529729189087 0.012473054606620178 3.986923913675392e-11 10.399362052320106 -0.054108354178586504 MVNHFIAEFK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MVNHFIAEFK 10 0 A8K7Q2;P11142;E9PKE3;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 774342900.0 162755100.0 352393300.0 259194500.0 False True 246911385.6916165 289505962.35358053 207964593.46601486 1.0 1.1725095687371951 0.8422640895375931 27.879418123332137 -6.7647960069293935 1.5947866434163833 1.0996054547972123 0.8407787805879516 0.7100994656757946 0.07261570702890094 0.2749330911610438 1.3791889325254456 0.03591144431384951 0.08588442595964073 1.718715497856833e-07 6.7647960069293935 -0.25882667420926064 MVNHFIAEFK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MVNHFIAEFK 10 0 A8K7Q2;P11142;E9PKE3;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 772927600.0 233060100.0 211492900.0 328374600.0 False True 319228717.1823851 202148444.3645054 250819282.5671735 1.0 0.6332401613135946 0.7857040080259221 28.250015198482068 -10.13400145379399 5.203606138134997 1.0000090546676912 0.7094720857644993 0.8288113499698866 0.06224310477878463 6.5386432624161185e-06 1.088017443882429e-06 0.06026850507686024 0.020088875685238792 7.345114093875366e-11 10.13400145379399 -0.2905369689031919 MVNHFIAEFK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MVNHFIAEFK 10 0 A8K7Q2;P11142;E9PKE3;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 391808200.0 193304500.0 93840200.0 104663500.0 False True 160741256.59133908 93334664.21677864 126548153.94065307 1.0 0.5806515775478118 0.7872786154856501 27.260165024394727 -10.146986938011551 5.506993023118387 1.000006341588653 0.6839650965166759 0.7572307367239735 0.08435513500192802 6.568002038114519e-06 1.0174388670442715e-06 0.08167814653201845 0.02722550275243403 7.128744704589649e-11 10.146986938011551 -0.3160412450719772 MVNHFIAEFK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MVNHFIAEFK 10 0 A8K7Q2;P11142;E9PKE3;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 863511600.0 162755100.0 436712100.0 264044400.0 False True 210689685.33265427 412408687.7342108 215991028.52433336 1.0 1.9574222966020662 1.0251618544273247 27.650544445424586 -6.639998706115008 2.0448108276784227 1.6261057889659511 1.029060025220635 0.15453051990913835 0.4096538875083316 0.533324765915086 4.2620839133982615 0.16315946464970477 0.4535280246213689 2.2908744779147973e-07 6.639998706115008 -0.5970457637453161 MVNHFIAEFKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MVNHFIAEFKR 11 1 A8K7Q2;P11142;E9PKE3;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 36445300.0 4686300.0 11503000.0 20256000.0 False True 7109459.714421366 9450199.776650796 16252392.721479813 1.0 1.3292430305894125 2.2860236043692925 22.76130849528108 -6.952164490460184 0.5345578775629289 0.9853869978123218 2.6736535111475237 0.9993603532418996 0.013795221996477675 0.08262815170581032 0.032454730572275624 0.015289197033353777 0.07916971094640313 1.1164403122595747e-07 6.952164490460184 1.688266513335202 up MVNHFIAEFKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVNHFIAEFKR 11 1 A8K7Q2;P11142;E9PKE3;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 26968700.0 11927000.0 12608000.0 2433700.0 False True 16336734.215055699 12050936.87091946 1858910.1836248308 1.0 0.7376588681851414 0.11378713512469867 23.961616275440523 -7.24958010688941 0.6104337482757058 1.0006890290381396 1.68845011363119e-23 0.9971858260529928 0.019717948673750294 0.09359377261190577 0.06360490240963088 0.01883932121956508 0.05708645213814467 5.6288528197898624e-08 7.24958010688941 -1.0006890290381396 down MVNHFIAEFKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVNHFIAEFKR 11 1 A8K7Q2;P11142;E9PKE3;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 69734300.0 4686300.0 33779000.0 31269000.0 False True 6066507.730783345 31899168.95587257 25578362.84703403 1.0 5.25824252955391 4.216324116301949 22.53243481737353 -10.126845617442106 7.435971747710136 0.9999987982760976 4.737283322927929 0.9449178723489148 0.4253614110129344 8.473429236544823e-06 9.953450820560982e-07 0.41185453780857867 0.13728480508103189 7.467141524188609e-11 10.126845617442106 3.737284524651832 MVPSAAASQNPESEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVPSAAASQNPESEKR 16 1 Q96PZ2 Q96PZ2 FAM111A Protein FAM111A 1 27869100.0 5725500.0 11290600.0 10853000.0 True False 7411772.616477839 10662268.184764937 8877865.361183917 1.0 1.438558457805438 1.1978059528494795 22.821387191365048 -10.034776984298022 4.181828642676317 0.9999716220663961 1.3181822052959944 0.699599517893004 0.098286798976783 68511646.92800614 198322310.88875398 32121.01496005562 0.0359692874030107 9.230453008951575e-11 10.034776984298022 0.3182105832295983 MVPTSDK(ub)GR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVPTSDKGR 9 1 P13639 P13639 EEF2 Elongation factor 2 1 4037750.0 1302200.0 1879400.0 856150.0 True False 1082836.9972413543 1869275.2991683062 1035167.0066096601 1.0 1.7262757958312187 0.9559767621967676 20.0463846553262 -6.659496567270351 1.9752015012523279 1.4677006417079796 0.9592245411291135 0.2332940682249226 0.30927125619550294 0.4856084597401425 3.6416642751104145 0.12654095927203385 0.34271091362653383 2.1902991404576225e-07 6.659496567270351 -0.5084761005788662 MVPTSDKGRFYAFGRVFSGLVSTGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MVPTSDKGRFYAFGRVFSGLVSTGLK 26 3 P13639 P13639 EEF2 Elongation factor 2 0 24508700.0 4650300.0 6824400.0 13034000.0 False True 4502678.771945529 9549418.508775864 9620004.388381502 1.0 2.120830508335314 2.1365069274583997 22.102352126583803 -10.9255029941152 0.7307157600186888 2.4254590550395947e-06 2.1335596642097223 0.9999771481340805 0.0025436149092768826 2.8482441795450355 0.3777771357754507 4.858709555453392 0.0023796512852085386 1.1871265167217865e-11 10.9255029941152 2.1335572387506674 MVPTSDKGRFYAFGRVFSGLVSTGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVPTSDKGRFYAFGRVFSGLVSTGLK 26 3 P13639 P13639 EEF2 Elongation factor 2 0 16128400.0 4650300.0 2873000.0 8605100.0 False True 3866930.4932203037 2857522.5787541475 10404386.624512969 1.0 0.738964039763347 2.6906060615142837 21.88275740201808 -6.8731866455451565 1.1171749026913353 0.849121112397268 2.812007232653871 0.967757779993645 0.15533392182238473 0.13383241115080544 0.31026318767389865 0.10768993401553575 0.25645400585454803 1.3391010619615028e-07 6.8731866455451565 1.9628861202566033 up MVPVSVQQSLAAYNQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVPVSVQQSLAAYNQR 16 0 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 12942100.0 3283800.0 5381500.0 4276800.0 False True 4305093.600364436 4578601.176922708 3834277.761962448 1.0 1.063531156798802 0.8906374908173581 22.03761317403424 -6.807216466363465 1.4259867025728257 1.0347391693443566 0.8877952016738495 0.8525039382386208 0.027423399303578438 0.21061043843609734 0.8445421177640429 0.015123221032145856 0.03503276830097382 1.5587753652994735e-07 6.807216466363465 -0.1469439676705071 MVPVSVQQSLAAYNQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVPVSVQQSLAAYNQR 16 0 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 9943500.0 3283800.0 3474800.0 3184900.0 False True 4497909.601358254 3321271.8463730104 2432692.2150744637 1.0 0.7384034230857087 0.5408495124801647 22.100823235557133 -7.1831326196695215 0.13131109200026317 1.3153230803598297 6.296193736846988e-10 0.9999982974629716 0.0002453076554096034 0.0889345904704668 0.005574614427477362 0.01843889148547425 0.03561826732640765 6.55944931076167e-08 7.1831326196695215 -1.3153230797302102 MVQEAEK(ub)YK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MVQEAEKYK 9 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 A8K7Q2;E9PM13;P11142;P0DMV9 HSPA8;HSPA1B;HSPA1A Heat shock cognate 71 kDa protein;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 1573052270.0 608695870.0 600100400.0 364256000.0 True False 798006180.1891898 510567759.49303824 326566283.3102774 1.0 0.6398042673955154 0.40922776216201195 29.571824678596357 -8.551252489897212 0.15249174071961852 1.4228586915712673 2.5511789742261853e-12 0.9998886981932736 0.0025647865607719587 0.17706451267250198 0.03890441833872443 0.17713131104406019 0.14793839613510065 2.8102665240968633e-09 8.551252489897212 -1.4228586915687162 down MVQEAEK(ub)YK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MVQEAEKYK 9 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 A8K7Q2;E9PM13;P11142;P0DMV9 HSPA8;HSPA1B;HSPA1A Heat shock cognate 71 kDa protein;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 2082373900.0 712649700.0 806145800.0 563578400.0 True False 690027025.3582228 1128044021.9348114 415960310.0504091 1.0 1.6347823787759543 0.6028174183967159 29.3620776261879 -6.7402895799097395 1.685781908496023 1.3775666719803683 0.6021902411689818 0.6061965067518531 0.26670590587338827 0.31728407522187424 1.7705876637673208 0.12515744936955886 0.30701025386521785 1.8184879185628772e-07 6.7402895799097395 -0.7753764308113865 MVQEAEK(ub)YK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MVQEAEKYK 9 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 A8K7Q2;E9PM13;P11142;P0DMV9 HSPA8;HSPA1B;HSPA1A Heat shock cognate 71 kDa protein;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 1962690120.0 698317220.0 977313100.0 287059800.0 True False 1059398276.5671705 802903941.5228966 230322304.70722035 1.0 0.7578867733526929 0.21740860807660273 29.980597920754757 -7.067654860806831 0.5003620352000633 1.0104079308889282 9.350347103324628e-12 0.9995449471492389 0.006978535867549326 0.07447980239384797 0.02832676855973222 0.00828223380819637 0.04078413260032641 8.557465150588791e-08 7.067654860806831 -1.010407930879578 down MVQEAEK(ub)YK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MVQEAEKYK 9 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 A8K7Q2;E9PM13;P11142;P0DMV9 HSPA8;HSPA1B;HSPA1A Heat shock cognate 71 kDa protein;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 1581191840.0 608695870.0 564064680.0 408431290.0 True False 833747182.5263764 539142437.3251421 311968231.2084593 1.0 0.6466497861995304 0.374176054500298 29.63503474011925 -7.702695573127704 0.20278983844334467 1.2140870926886842 1.0117079658389484e-15 0.9999062999020463 0.00247999552168186 0.1311023554199353 0.02561419825315032 0.047992372528039055 0.08266142386094923 1.982916501315643e-08 7.702695573127704 -1.214087092688683 down MVQEAEK(ub)YK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MVQEAEKYK 9 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 A8K7Q2;E9PM13;P11142;P0DMV9 HSPA8;HSPA1B;HSPA1A Heat shock cognate 71 kDa protein;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 2083016480.0 712649700.0 1078713270.0 291653510.0 True False 592599801.2847122 1072902027.5066904 352636910.4875324 1.0 1.8105001472844215 0.5950675476485848 29.142482901622177 -6.726962144431653 1.7343104559319644 1.4893939012373878 0.5961813540743798 0.5451475075135253 0.3408033846813275 0.3419511933398724 2.0135505412911097 0.15581526234689297 0.3879813378529005 1.8751579503381905e-07 6.726962144431653 -0.893212547163008 MVQEAEK(ub)YK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MVQEAEKYK 9 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 A8K7Q2;E9PM13;P11142;P0DMV9 HSPA8;HSPA1B;HSPA1A Heat shock cognate 71 kDa protein;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 2232136340.0 698317220.0 1127423420.0 406395700.0 True False 903985407.1803217 1064681315.5921636 332435852.5720159 1.0 1.1777638301851339 0.3677447112879152 29.751724242847207 -6.849178119810589 1.2389999364685114 1.0947991103795651 0.33586294723415605 0.9391128403515419 0.08577323345683682 0.15835796046104347 0.4682098302076702 0.05418162546181637 0.12531930405489194 1.415213230990297e-07 6.849178119810589 -0.758936163145409 down MVQEAEK(ub)YK(ub)AEDEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVQEAEKYKAEDEK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 2 13979700.0 6296800.0 5556800.0 2126100.0 True False 8255165.778297949 4727747.100236748 1906111.566991293 1.0 0.5727016546009953 0.23089924759624822 22.976865756616174 -7.8919615593437085 0.29525837266546723 1.1198446787834684 1.1147794004108569e-11 0.9993458856535397 0.00804686939370292 0.11060265024403347 0.05106326822303416 0.04983675195067589 0.08687358189233599 1.2824440904551281e-08 7.8919615593437085 -1.1198446787723206 down MVQEAEK(ub)YK(ub)AEDEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MVQEAEKYKAEDEK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 2 18748800.0 7421400.0 7919600.0 3407800.0 True False 7185811.719268981 11081937.580168417 2515194.9481913853 1.0 1.5421970423260396 0.35002238389391843 22.776719704047007 -6.783046958194762 1.523893621126288 1.3057921158765982 0.33964322220963156 0.7780499959532732 0.22960568831233127 0.24587308981289435 1.1279377926732896 0.11864577548359409 0.27926219199588076 1.6479841932066373e-07 6.783046958194762 -0.9661488936669667 down MVQEAEK(ub)YK(ub)AEDEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MVQEAEKYKAEDEK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 2 28554900.0 15448600.0 7708900.0 5397400.0 True False 23436655.643943015 6333186.565089395 4330601.524235546 1.0 0.2702256952231215 0.1847789885223982 24.482263379443882 -13.999999999999998 0.3026585663480241 7.7595230350488205 0.16432821845835285 0.9996557542615839 0.006787479324435209 16.763688613926544 0.17479732024216352 71.06832249784037 0.03053109625674174 1.0000000000000041e-14 13.999999999999998 -7.5951948165904675 MVQEAEK(ub)YK(ub)AEDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVQEAEKYKAEDEK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 2 13870380.0 6296800.0 5157600.0 2415980.0 True False 8624897.124621682 4929720.17809758 1845375.2826699773 1.0 0.5715685772094139 0.21395910652684125 23.040075818139066 -7.848293859883299 0.31610888001182447 1.0996764166107678 1.0575525722709685e-10 0.9991887965468743 0.009152107791493426 0.11356724827088113 0.05357363076819223 0.0436997883309814 0.08381448133892865 1.418097659092103e-08 7.848293859883299 -1.0996764165050126 down MVQEAEK(ub)YK(ub)AEDEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVQEAEKYKAEDEK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 2 19614090.0 7421400.0 10294600.0 1898090.0 True False 6171222.9237651685 10239140.94648188 2294971.843223422 1.0 1.659175348706218 0.3718828296390921 22.557124979481284 -6.76750297632638 1.5839466069544648 1.3792852351565852 0.36530329805369477 0.720957313304198 0.2776381054801205 0.2704785546811198 1.338840729165118 0.1381923282102402 0.329723150110762 1.7080360144307407e-07 6.76750297632638 -1.0139819371028904 MVQEAEK(ub)YK(ub)AEDEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVQEAEKYKAEDEK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 2 27215400.0 15448600.0 9796600.0 1970200.0 True False 19998517.23743247 9251410.598096482 1611643.8159591418 1.0 0.4626048265608433 0.08058816545371313 24.25338970153633 -8.196954893361692 0.41970839854504516 1.0647091976176972 5.107666147360448e-16 0.9965430949688815 0.02217357169552231 0.10530417025177909 0.10976404456078682 0.0606804723321956 0.08079019086590154 6.353969219391448e-09 8.196954893361692 -1.0647091976176968 MVQEAEK(ub)YK(ub)AEDEVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MVQEAEKYKAEDEVQR 16 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 2 14458500.0 3322000.0 6216400.0 4920100.0 True False 5039716.8707312355 5107034.851045111 3947640.0784435607 1.0 1.0133574925021747 0.783305923666061 22.26491125529826 -6.8931242497894285 1.0036918849591678 1.0114510970287391 0.7622624413548377 0.9828246750114453 0.013818411386490117 0.1166458196851391 0.2073212041300843 0.010444557431350183 0.026349743263156443 1.2790153310053535e-07 6.8931242497894285 -0.24918865567390147 MVQEAEK(ub)YKAEDEK ddPTM_RPMI8226_Bortezomib_1h_R1 2 MVQEAEKYKAEDEK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 760474140.0 266885200.0 355455110.0 138133830.0 True False 349889081.7199532 302422593.1411666 123841066.34486105 1.0 0.8643384687928669 0.3539437862310373 28.38232240511638 -6.946283702650037 0.5982551369167328 1.0057716110543191 0.18646156489987467 0.9988764241355593 0.0093234496623794 0.08501326028704073 0.04240935431948459 0.009585579431181242 0.042868051439733226 1.1316608648373806e-07 6.946283702650037 -0.8193100461544445 down MVQEAEK(ub)YKAEDEK ddPTM_RPMI8226_Bortezomib_2h_R1 2 MVQEAEKYKAEDEK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 1055857220.0 374201620.0 391879500.0 289776100.0 True False 362322794.40071106 548359027.974596 213875046.31334043 1.0 1.5134544015691658 0.5902886862723995 28.43270033037286 -6.755745292061488 1.6284956666168915 1.299814384907406 0.5876079099172006 0.6733634884788288 0.21584827596746076 0.29012097301737183 1.5153735647341575 0.10463062013683824 0.25251057113461517 1.754909431130668e-07 6.755745292061488 -0.7122064749902054 MVQEAEK(ub)YKAEDEK ddPTM_RPMI8226_Bortezomib_8h_R1 2 MVQEAEKYKAEDEK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 2952381500.0 1043997100.0 1343780000.0 564604400.0 True False 1583819927.111524 1103971959.9989378 453010092.86510026 1.0 0.6970312351179315 0.28602373610191467 30.560761171076063 -7.144985977040755 0.3577344680955581 1.0413391877344322 3.412929836488432e-12 0.9998668288382428 0.00337647628854785 0.0814311423435439 0.018271765003157442 0.00746049062665676 0.03808560303458793 7.161665341815586e-08 7.144985977040755 -1.0413391877310194 down MVQEAEK(ub)YKAEDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MVQEAEKYKAEDEK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 716280870.0 266885200.0 220912500.0 228483170.0 True False 365559870.74134165 211151855.29005355 174520151.00459513 1.0 0.5776122386241289 0.4774051119196285 28.44553246663927 -13.999999999999998 0.20210141664200984 3.3669987418069938 0.41365710640625863 0.9994871403316683 0.00512850790530621 12.573230964652094 0.14253778392832894 11.77486748573095 0.06282116210967974 1.0000000000000041e-14 13.999999999999998 -2.953341635400735 MVQEAEK(ub)YKAEDEK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MVQEAEKYKAEDEK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 980796010.0 374201620.0 453161150.0 153433240.0 True False 311165226.9725472 450719880.93950474 185515421.08885333 1.0 1.448490518444948 0.5961958631875681 28.213105605807137 -6.763676288452026 1.598246286395601 1.2593013265314998 0.5924570093913848 0.7059958372669732 0.1887512193017357 0.27675405235968076 1.3940085588936908 0.09313918616167566 0.2230578854345134 1.7231524884319284e-07 6.763676288452026 -0.666844317140115 MVQEAEK(ub)YKAEDEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVQEAEKYKAEDEK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 348527100.0 213937100.0 87936200.0 46653800.0 True False 276945793.2807059 83042473.1678677 38163287.108412616 1.0 0.29985100038583273 0.1378005661553096 28.045028383683697 -13.999999999999849 0.20559698644569344 4.977730194717354 0.03817709412155431 0.9994880174711877 0.008465776759075684 12.64720028942078 0.14374628938506115 20.27977401375496 0.09903966238962193 1.0000000000003477e-14 13.999999999999849 -4.939553100595799 MVQEAEK(ub)YKAEDEK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVQEAEKYKAEDEKQR 16 3 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 2 23332500.0 9781200.0 10111000.0 3440300.0 True False 12823247.921275537 8602478.212369308 3084330.757687855 1.0 0.6708501828227629 0.2405264856940436 23.612258383769884 -7.2981393928076965 0.38204492273005614 1.037418420055392 3.163965843015331e-23 0.9995840495164583 0.006342177481810648 0.10210694137093385 0.02991686449382778 0.01179451773109603 0.051358243075353464 5.033390292506442e-08 7.2981393928076965 -1.037418420055392 down MVQEAEK(ub)YKAEDEK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MVQEAEKYKAEDEKQR 16 3 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 2 29568800.0 12860000.0 11259000.0 5449800.0 True False 12451766.339208098 15754777.414909339 4022333.88950449 1.0 1.2652644601353245 0.3230331970524513 23.5698470738193 -6.831520304619394 1.321040221693118 1.1415972823970653 0.2968699043849624 0.9088965962858161 0.11974200432100024 0.17893906291160783 0.6101801536062262 0.07115628598410055 0.16375247667483578 1.4739396280955118e-07 6.831520304619394 -0.8447273780121028 down MVQEAEK(ub)YKAEDEK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MVQEAEKYKAEDEKQR 16 3 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 2 101162200.0 47692600.0 33434600.0 20035000.0 True False 72353160.99609771 27467934.404277857 16075073.46834757 1.0 0.37963696438583117 0.22217513716110565 26.108552711428462 -13.9999999999999 0.19253060417559648 4.355110066901202 0.11204229831780188 0.9994882150605878 0.007595944679979497 12.393025504715771 0.1391481097871228 15.612541210395456 0.10614882499955865 1.0000000000002291e-14 13.9999999999999 -4.2430677685833995 MVQEAEK(ub)YKAEDEK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVQEAEKYKAEDEKQR 16 3 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 2 23028700.0 9781200.0 9177400.0 4070100.0 True False 13397573.966991091 8771912.122396592 3108826.2063407237 1.0 0.654738846302234 0.23204396661666074 23.675468445292775 -7.371955601724207 0.37572682695203513 1.0420895979272504 5.5140782047905676e-11 0.999472325574056 0.007214035492803566 0.11069767050873985 0.03426965431054374 0.014423302014968754 0.057001100044612424 4.246629753663802e-08 7.371955601724207 -1.0420895978721096 down MVQEAEK(ub)YKAEDEK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVQEAEKYKAEDEKQR 16 3 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 2 30617400.0 12860000.0 14918000.0 2839400.0 True False 10693659.794596702 14837633.773008825 3433105.412097725 1.0 1.3875169079631646 0.3210412036702726 23.350252349253577 -6.808365821123723 1.4212291129228463 1.2115997070901148 0.30303880155501767 0.8555826260608903 0.16750368612958083 0.20901985216297153 0.8323921611670263 0.09267847734601131 0.21456361428029874 1.5546555402814333e-07 6.808365821123723 -0.9085609055350972 down MVQEAEK(ub)YKAEDEK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVQEAEKYKAEDEKQR 16 3 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 2 15807100.0 9128600.0 4893300.0 1785200.0 True False 11817152.651607655 4620983.5534435995 1460311.9176988425 1.0 0.3910403537704103 0.12357561595010584 23.49437912356282 -9.260293791678478 0.28260248752415656 1.3216027568385023 9.580431703983309e-25 0.9987873044311685 0.01277129712021995 0.6763652672703648 0.10679350417256661 0.3099271932117715 0.09755239834030885 5.491692459744632e-10 9.260293791678478 -1.3216027568385023 MVQEAEK(ub)YKAEDEKQR ddPTM_RPMI8226_Bortezomib_1h_R1 2 MVQEAEKYKAEDEKQR 16 3 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 91293600.0 44906100.0 10368800.0 36018700.0 True False 58872331.97129099 8821815.457265835 32291830.43976731 1.0 0.14984654356086627 0.5485060529879192 25.811086439081233 -10.75595393550706 6.497826616753392 1.01689251631466 0.349176298437105 0.7803906384005794 0.16275206320075664 0.03840659653799195 0.0014424772328613012 0.15195926175406085 0.05252800252811892 1.7540665412785755e-11 10.75595393550706 -0.6677162178775551 MVQEAEK(ub)YKAEDEKQR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MVQEAEKYKAEDEKQR 16 3 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 364995300.0 110663900.0 102937700.0 151393700.0 True False 167885226.9147847 84567663.17907889 121470668.83678405 1.0 0.5037230775641969 0.7235339944379992 27.322900044796867 -10.312543213033294 5.760044232038045 1.0000423861082521 0.6136285360010965 0.804670523398691 0.0897374310390316 4.885080655697322e-05 5.83044176381585e-06 0.08689739734383838 0.028962631328799397 4.8691907348649466e-11 10.312543213033294 -0.3864138501071557 MVQEAEK(ub)YKAEDEKQR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MVQEAEKYKAEDEKQR 16 3 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 149340580.0 44906100.0 101260200.0 3174280.0 True False 61509098.71172235 96786189.54129755 2424580.440348697 1.0 1.57352638176199 0.039418240408823 25.874296500604125 -6.80544356177575 1.4334863618648632 1.3142916390307169 0.015259315257153495 0.8476254551681242 0.24705626960544935 0.21307968148205514 0.8637580056469136 0.13554704835520107 0.3142609068550273 1.5651517034423967e-07 6.80544356177575 -1.2990323237735635 down MVQEAEK(ub)YKAEDEKQR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MVQEAEKYKAEDEKQR 16 3 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 489892500.0 110663900.0 174114900.0 205113700.0 True False 143256600.06159142 164425252.7557019 167785111.2442893 1.0 1.1477673816425162 1.1712208105745365 27.094026366889317 -13.861398070030328 0.26048646655442864 4.601502615311328e-05 1.179807074812585 0.9995558253410587 0.001597370830130329 13.44195104915449 0.1609848828285192 7.059906738479977 0.010235033958164103 1.3759477106505236e-14 13.861398070030328 1.1797610597864319 MVQEAEK(ub)YKAEDEVQR ddPTM_RPMI8226_Bortezomib_1h_R1 2 MVQEAEKYKAEDEVQR 16 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 279047550.0 102773250.0 106464400.0 69809900.0 True False 134736726.00756884 90580326.51498085 62586641.211845845 1.0 0.672276440128822 0.46451062799559223 27.00556790765109 -8.745765056746334 0.12788387406005572 1.5145953434939972 2.2008423393445765e-10 0.9999303496825851 0.0018396573861325365 0.28718096953341016 0.0361213356251385 0.2254957703624222 0.17245229228873477 1.795704798814195e-09 8.745765056746334 -1.514595343273913 MVQEAEK(ub)YKAEDEVQR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MVQEAEKYKAEDEVQR 16 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 484514700.0 160149100.0 126796400.0 197569200.0 True False 155065254.48168528 177426863.75449064 145819899.5710469 1.0 1.144207735946717 0.9403776497736934 27.20830021657185 -6.716644041988608 1.7713916600530268 1.0880473110205175 0.9407537252701382 0.4966303695834916 0.060709462583898366 0.3618811353233713 2.217304962446377 0.027232226564501485 0.0686343839570981 1.9202419715118757e-07 6.716644041988608 -0.14729358575037932 MVQEAEK(ub)YKAEDEVQR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MVQEAEKYKAEDEVQR 16 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 2028460900.0 272619900.0 466832000.0 1289009000.0 True False 413584319.48436636 383522182.2249364 1034235806.1572857 1.0 0.927313159993808 2.5006649368300824 28.623606247868324 -6.896070902647036 0.9857918406407168 0.9273488631054844 2.6532366814298345 0.9845074880623959 0.09025989309293488 0.11435485179047002 0.19418713627867662 0.0691478628823083 0.17661054998229453 1.270366689002052e-07 6.896070902647036 1.7258878183243502 up MVQEAEK(ub)YKAEDEVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MVQEAEKYKAEDEVQR 16 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 307702950.0 102773250.0 122583300.0 82346400.0 True False 140771297.86765102 117167164.47723529 62897876.29734311 1.0 0.8323228261161048 0.44680895360130746 27.068777969173983 -6.957230542153629 0.47285299331339425 1.009905235222707 0.2533462597916101 0.9996532862193558 0.004312490579873423 0.0807056943327579 0.02490246327779534 0.0053593518708490466 0.03181254806434943 1.1034926831106319e-07 6.957230542153629 -0.7565589754310968 down MVQEAEK(ub)YKAEDEVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MVQEAEKYKAEDEVQR 16 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 472769600.0 160149100.0 226837900.0 85782600.0 True False 133171072.45807524 225615879.208902 103719345.04607123 1.0 1.6941808385595913 0.7788429058324512 26.988705492006126 -6.703950345980044 1.8171219498156008 1.4293922215674884 0.7813870789066636 0.43617150107655833 0.2928175040796316 0.38737013957124633 2.4894154507018116 0.1284355058858708 0.32865950213005923 1.9771956851250233e-07 6.703950345980044 -0.6480051426608248 MVQEAEK(ub)YKAEDEVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MVQEAEKYKAEDEVQR 16 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 1886137700.0 272619900.0 1310794000.0 302723800.0 True False 352911834.6916302 1237847161.619469 247631174.6084927 1.0 3.5075252228395337 0.701679995585497 28.394732569960773 -6.671073327432739 1.9337332366605138 2.5990621387121946 0.7130027212158283 0.28378338065966147 1.0648781532109162 0.4586306659105014 3.307369864718179 0.44318888570654286 1.182363676099252 2.1326847945858773e-07 6.671073327432739 -1.8860594174963663 MVQEAEKYK(ub)AEDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVQEAEKYKAEDEK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 1296260.0 317430.0 978830.0 0.0 True False 434792.44922320236 935582.0540420446 0.0 1.0 2.1517900223740085 0.0 18.72996736060969 -6.765402685594154 1.6186882525902653 1.6677723593729816 7.068558423854208e-09 0.6960755828227699 0.4846932171417252 0.2777220857489924 1.439681833191312 0.23718544837706287 0.561015017442786 1.7163162500857936e-07 6.765402685594154 -1.6677723523044232 MVQFHFTNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVQFHFTNK 9 0 M0QZQ2;Q71SY5-5;Q71SY5;Q71SY5-4;B9TX31;Q71SY5-6 M0QZQ2 MED25 Mediator of RNA polymerase II transcription subunit 25 0 6346600.0 2177100.0 1773700.0 2395800.0 False True 2854199.1830663937 1509070.8738284495 2147905.598136372 1.0 0.5287195381393065 0.7525422930815855 21.444654587527836 -10.04346118659191 5.038418818975257 1.000005446249402 0.6406309156083081 0.7746354184031776 0.0913752570795219 126498041.16209841 9.391316573828533 7992.7077245386945 0.03128018093655172 9.047712945985206e-11 10.04346118659191 -0.3593745306410938 MVQFHFTNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MVQFHFTNK 9 0 M0QZQ2;Q71SY5-5;Q71SY5;Q71SY5-4;B9TX31;Q71SY5-6 M0QZQ2 MED25 Mediator of RNA polymerase II transcription subunit 25 0 6175230.0 2737200.0 903730.0 2534300.0 False True 2650309.084267528 1264594.1018896902 1870490.8026296794 1.0 0.4771496688429414 0.7057632687949796 21.337729188749922 -10.3182384880793 5.775850220274153 1.0000471504627642 0.5914564688189599 0.8098156137580522 0.09333111135721588 5.667349481775458e-05 6.689620122518955e-06 0.09037785265360256 0.03012248666412624 4.8057537325066206e-11 10.3182384880793 -0.4085906816438043 MVQFHFTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVQFHFTNK 9 0 M0QZQ2;Q71SY5-5;Q71SY5;Q71SY5-4;B9TX31;Q71SY5-6 M0QZQ2 MED25 Mediator of RNA polymerase II transcription subunit 25 0 7128900.0 2177100.0 2525900.0 2425900.0 False True 2982032.7039153012 2414297.385965694 1852952.382978791 1.0 0.8096146574099636 0.6213722540822344 21.507864649050727 -6.971264892064554 0.22594546080822384 1.0805478856295083 0.34508636149105426 0.9999906360972131 0.00047297177399690415 0.07589440244191356 0.007544957422738095 0.00498469103297222 0.018846601633731443 1.0684030224267443e-07 6.971264892064554 -0.7354615241384541 MVQFHFTNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVQFHFTNK 9 0 M0QZQ2;Q71SY5-5;Q71SY5;Q71SY5-4;B9TX31;Q71SY5-6 M0QZQ2 MED25 Mediator of RNA polymerase II transcription subunit 25 0 5163700.0 2737200.0 1411100.0 1015400.0 False True 2276103.078520225 1403498.1242185796 1227715.4453208542 1.0 0.616623270476416 0.5393936051960508 21.118134464184198 -13.999999999999995 0.22523932513900227 3.368035712820972 0.5001015821498203 0.9995036746447381 0.004487120833414478 13.14748534803911 0.15030653637180427 13.886958044764839 0.041310929265787916 1.0000000000000123e-14 13.999999999999995 -2.8679341306711517 MVQFHFTNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVQFHFTNK 9 0 M0QZQ2;Q71SY5-5;Q71SY5;Q71SY5-4;B9TX31;Q71SY5-6 M0QZQ2 MED25 Mediator of RNA polymerase II transcription subunit 25 0 9876300.0 2670800.0 4244600.0 2960900.0 False True 3457403.2493387465 4008384.2786967275 2422046.5813995665 1.0 1.1593626747077768 0.7005392217013738 21.72125744943395 -6.812891662406134 1.4022656875898736 1.0865607175442602 0.6919646472435659 0.8672535022917535 0.0692990471554723 0.2028893918252864 0.7857189769878116 0.038851739672000334 0.08976344073402985 1.5385383908826803e-07 6.812891662406134 -0.3945960703006943 MVQLHLK(ub)SDKPQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVQLHLKSDKPQTK 14 2 P15884-2;P15884-3;A0A1B0GVR6;P15884-13;P15884-4;P15884-11;E9PH57;A0A1B0GW91;A0A1B0GWD5;H3BTP3;A0A1B0GVB8;A0A0D9SGH7;P15884-6;H3BPJ7;P15884-16;P15884-8;P15884-9;P15884-15;P15884-7;P15884-5;P15884-10;P15884-14;P15884-12;P15884 P15884-2;P15884-6 TCF4 Transcription factor 4 1 7994560.0 1571000.0 3192250.0 3231310.0 True False 2059596.21358564 2715978.743293037 2896965.038114221 1.0 1.3186947642347198 1.4065694134632192 20.973930092287155 -12.654662837420862 0.19996194742821952 2.553455855558353e-09 1.4673007014573183 0.99943258783937 0.0041607117461242744 7.105832195291854 0.132130007202955 2.8884606080436384 0.055826171977889257 2.2148135028903081e-13 12.654662837420862 1.4673006989038624 MVQLHLK(ub)SDKPQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MVQLHLKSDKPQTK 14 2 P15884-2;P15884-3;A0A1B0GVR6;P15884-13;P15884-4;P15884-11;E9PH57;A0A1B0GW91;A0A1B0GWD5;H3BTP3;A0A1B0GVB8;A0A0D9SGH7;P15884-6;H3BPJ7;P15884-16;P15884-8;P15884-9;P15884-15;P15884-7;P15884-5;P15884-10;P15884-14;P15884-12;P15884 P15884-2;P15884-6 TCF4 Transcription factor 4 1 13751160.0 3743160.0 1425700.0 8582300.0 True False 3624335.4347021976 1994989.4449272805 6334338.1665188465 1.0 0.5504428276217772 1.747724039521558 21.789285053291845 -6.804995154359905 1.4354314947008817 0.7535081548033534 1.7663634321659132 0.8463663521278825 0.1935561805367959 0.21370429725198967 0.8687228398063304 0.106054898449169 0.24593332639323967 1.5667685512286186e-07 6.804995154359905 1.0128552773625596 MVQLHLK(ub)SDKPQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVQLHLKSDKPQTK 14 2 P15884-2;P15884-3;A0A1B0GVR6;P15884-13;P15884-4;P15884-11;E9PH57;A0A1B0GW91;A0A1B0GWD5;H3BTP3;A0A1B0GVB8;A0A0D9SGH7;P15884-6;H3BPJ7;P15884-16;P15884-8;P15884-9;P15884-15;P15884-7;P15884-5;P15884-10;P15884-14;P15884-12;P15884 P15884-2;P15884-6 TCF4 Transcription factor 4 1 7135700.0 1571000.0 3823000.0 1741700.0 True False 2151841.154678669 3654087.219029595 1330346.33143747 1.0 1.6981212628472357 0.6182363082632503 21.037140153810046 -6.732193137122207 1.715441479774583 1.4190990297378605 0.6186405106834748 0.5693325491897187 0.2934254219934705 0.33213159751386245 1.9157871951574856 0.13550168802128454 0.3353799326184323 1.852707513992244e-07 6.732193137122207 -0.8004585190543857 MVQLHLK(ub)SDKPQTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVQLHLKSDKPQTK 14 2 P15884-2;P15884-3;A0A1B0GVR6;P15884-13;P15884-4;P15884-11;E9PH57;A0A1B0GW91;A0A1B0GWD5;H3BTP3;A0A1B0GVB8;A0A0D9SGH7;P15884-6;H3BPJ7;P15884-16;P15884-8;P15884-9;P15884-15;P15884-7;P15884-5;P15884-10;P15884-14;P15884-12;P15884 P15884-2;P15884-6 TCF4 Transcription factor 4 1 17780360.0 3743160.0 8680000.0 5357200.0 True False 3112603.3901044056 8633239.1171549 6477365.751105845 1.0 2.7736393093324097 2.0810122393680794 21.56969032872612 -10.388313768195951 5.7007255064919775 0.9995349840979473 2.4273257743502485 0.8498996750566498 0.2827638172419464 0.0016716631967413048 0.00017936843167964397 0.2738637643342271 0.09126162959067256 4.089650847051798e-11 10.388313768195951 1.4277907902523013 MVQTPYGIVPDVYEK(ub)ESR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVQTPYGIVPDVYEKESR 18 1 O95147 O95147 DUSP14 Dual specificity protein phosphatase 14 1 16455100.0 5066600.0 7240600.0 4147900.0 True False 6642361.665024191 6160330.703637744 3718715.097466337 1.0 0.9274307865642707 0.5598483318135905 22.66326484653574 -6.939517186098179 0.6640482777079758 1.0041623475734516 0.4621179811097944 0.998099854076369 0.008398876097947575 0.08798785170552606 0.05561973217470855 0.008146009997262506 0.03170504984142027 1.1494307567246889e-07 6.939517186098179 -0.5420443664636572 MVQTPYGIVPDVYEK(ub)ESR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MVQTPYGIVPDVYEKESR 18 1 O95147 O95147 DUSP14 Dual specificity protein phosphatase 14 1 31496100.0 12161000.0 10606000.0 8729100.0 True False 11774955.711594844 14841031.109559352 6442686.842613247 1.0 1.260389548212511 0.5471516836593371 23.48921829774109 -6.807920585954969 1.423409325135363 1.14226016868855 0.5352747572713947 0.8542988076695617 0.11248580725025352 0.20964444531182108 0.8375703980808771 0.062147675371218895 0.143890385555044 1.556250177755256e-07 6.807920585954969 -0.6069854114171553 MVQTPYGIVPDVYEK(ub)ESR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVQTPYGIVPDVYEKESR 18 1 O95147 O95147 DUSP14 Dual specificity protein phosphatase 14 1 17973900.0 5066600.0 5918700.0 6988600.0 True False 6939858.939716705 5657192.263476452 5338036.614734965 1.0 0.8151739556405719 0.7691851752469296 22.72647490805863 -13.999999999999998 0.19535093176922275 2.0097851743799082 0.7379115847588191 0.9994873425609179 0.0022585331260784004 12.442810500089951 0.14016058071211088 4.79189011893035 0.03033186859974815 1.0000000000000041e-14 13.999999999999998 -1.271873589621089 MVSISNYPLSAALTCAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVSISNYPLSAALTCAK 17 0 Q92979;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 0 6805200.0 1434800.0 3190200.0 2180200.0 False True 1881036.6946229637 2714234.5953022023 1954613.8179551393 1.0 1.4429461174579825 1.0391151983066038 20.84309656206312 -10.501800540333758 6.753407779218132 0.9998958814422663 1.241030657882293 0.3220291545828228 0.16486328238000084 0.0002585612179837556 1.9074018111426113e-05 0.15969672329078985 0.05320939558823618 3.14919432148421e-11 10.501800540333758 0.24113477644002668 MVSISNYPLSAALTCAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVSISNYPLSAALTCAK 17 0 Q92979;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 0 9317600.0 1434800.0 3224500.0 4658300.0 False True 1965284.3340120646 3082030.9280044306 3558105.480699985 1.0 1.5682366539362596 1.810478727745327 20.906306623586012 -10.817547822527906 0.16990647473069775 4.201688307867366e-19 2.076249756768814 0.9995456993745518 0.00724007468145372 2.826597520419702 0.09411226568325971 1.3212075538334327 0.18924178813157266 1.522131513470706e-11 10.817547822527906 2.076249756768814 MVSYIQCK(ub)EVDYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVSYIQCKEVDYR 13 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 6895400.0 1643900.0 2491000.0 2760500.0 True False 2155168.8195502437 2119352.509841952 2474869.9405858 1.0 0.9833812045797108 1.1483415675539859 21.039369452832776 -6.882095481431602 1.068074832671806 0.9893853358340706 1.1605108384848741 0.9753354684055837 0.011646312814540738 0.12578867891053605 0.2612237528677909 0.00838334557053668 0.020384892949060367 1.3119114381745587e-07 6.882095481431602 0.1711255026508035 MVVESAYEVIK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MVVESAYEVIKLK 13 1 A0A5F9ZHM4;P07195;A0A3B3IS95 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 15422600.0 4383700.0 4113900.0 6925000.0 True False 4244541.84301606 5756601.723705084 5111134.754453124 1.0 1.3562362998439883 1.204166419719233 22.017177406617066 -10.323187078488058 5.571592017529458 0.999952516276473 1.2802013597816144 0.8190639828613445 0.06208226859198899 3.662406249307247e-05 4.449015002662631e-06 0.060121062527203076 0.020036966029293855 4.7513051266875985e-11 10.323187078488058 0.28024884350514145 MVVESAYEVIK(ub)LK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MVVESAYEVIKLK 13 1 A0A5F9ZHM4;P07195;A0A3B3IS95 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 40631400.0 6940800.0 5215600.0 28475000.0 True False 10529701.040448941 4284835.430331199 22846903.768964164 1.0 0.40692849814741866 2.169758066368622 23.327961140120795 -6.815971007576929 1.3892827436219732 0.6789803696657672 2.204996714210646 0.8748495616767549 0.25909688010449416 0.19876931794507652 0.7549124829719233 0.1465956596681199 0.33828489238387854 1.5276680381654758e-07 6.815971007576929 1.5260163445448789 up MVVESAYEVIK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVVESAYEVIKLK 13 1 A0A5F9ZHM4;P07195;A0A3B3IS95 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 13040200.0 4383700.0 4977200.0 3679300.0 True False 3645240.780837757 4950386.835703153 4448624.6188389 1.0 1.3580411098565195 1.2203925299597103 21.797582682051342 -10.185172798659094 5.30847696473528 0.9999863311455849 1.2892168199081995 0.854784125804354 0.05619479742794743 9.091207685670158e-06 1.3954974392516494e-06 0.05441294819534294 0.018136792881785515 6.528707343932666e-11 10.185172798659094 0.2892304887626146 MVVESAYEVIK(ub)LK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVVESAYEVIKLK 13 1 A0A5F9ZHM4;P07195;A0A3B3IS95 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 32989000.0 6940800.0 9194200.0 16854000.0 True False 8985002.423622278 8682534.687648643 13786744.936643664 1.0 0.9663363768073758 1.5344174978069263 23.099087462213244 -6.892828533798816 1.0055233134031496 0.971513479195786 1.5860693417145422 0.9826469364855117 0.03427964998207654 0.11687751431037555 0.20869362352442752 0.025875102179685177 0.06519833196396833 1.2798865234785169e-07 6.892828533798816 0.6145558625187562 MVVNEGSDGGQSVYHVHLHVLGGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 MVVNEGSDGGQSVYHVHLHVLGGR 24 0 P49773 P49773 HINT1 Histidine triad nucleotide-binding protein 1 0 512024600.0 199894700.0 180240100.0 131889800.0 False True 262063887.48302874 153348979.6504072 118243108.67229591 1.0 0.5851587608015548 0.4511995521700919 27.965343322461376 -13.999999999999998 0.15810517332244445 3.0350669457354735 0.31671851610848034 0.9995414808605703 0.0050025947563263565 11.997609373982451 0.12558868053561734 7.488752365590836 0.12228278057900012 1.0000000000000041e-14 13.999999999999998 -2.7183484296269933 MVVNEGSDGGQSVYHVHLHVLGGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MVVNEGSDGGQSVYHVHLHVLGGR 24 0 P49773 P49773 HINT1 Histidine triad nucleotide-binding protein 1 0 809861700.0 322953000.0 192647700.0 294261000.0 False True 312701033.7905343 269572931.25448346 217185216.45922443 1.0 0.8620787977153264 0.6945458856548199 28.22020874792377 -6.968525681993504 0.29125484569095866 1.0322473621450687 0.5191921582102892 0.9999684886070098 0.0007010816750835896 0.07678405963822804 0.01073360977841283 0.0029073047406763413 0.015170716333775642 1.075163018774129e-07 6.968525681993504 -0.5130552039347795 MVVNEGSDGGQSVYHVHLHVLGGR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MVVNEGSDGGQSVYHVHLHVLGGR 24 0 P49773 P49773 HINT1 Histidine triad nucleotide-binding protein 1 0 3022563000.0 900577700.0 981001800.0 1140983500.0 False True 1366242211.9489272 805934364.1879531 915467611.1141661 1.0 0.5898912777978789 0.6700624553301301 30.347566126048356 -10.098833710061172 5.133498431642312 1.0000082375534902 0.6299768665656453 0.9659895425180794 0.03272974617590236 3.2784018896542976e-06 5.754631589082017e-07 0.031691189783634485 0.010563480154837884 7.964642556024197e-11 10.098833710061172 -0.3700313709878449 MVVNEGSDGGQSVYHVHLHVLGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MVVNEGSDGGQSVYHVHLHVLGGR 24 0 P49773 P49773 HINT1 Histidine triad nucleotide-binding protein 1 0 967891000.0 199894700.0 382400700.0 385595600.0 False True 273801172.54115015 365504972.6439886 294525860.87066084 1.0 1.3349284418753031 1.0756924747150085 28.028553383984267 -10.48910247625036 5.406545218634286 0.9996450064129384 1.2053104582951566 0.45543139599423044 0.10583264041993931 0.00045363181143736285 4.2866294511236456e-05 0.10264718657640955 0.03415733781929816 3.242630951087869e-11 10.48910247625036 0.2056654518822182 MVVNEGSDGGQSVYHVHLHVLGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MVVNEGSDGGQSVYHVHLHVLGGR 24 0 P49773 P49773 HINT1 Histidine triad nucleotide-binding protein 1 0 515146770.0 322953000.0 98082900.0 94110870.0 False True 268549728.7437315 97554507.94976862 113789017.79750161 1.0 0.3632642207688163 0.42371674821569777 28.000614023358047 -10.26461954061106 5.746386595565329 1.0000360625524722 0.3934904845046265 0.9926040998394235 0.024679640984433135 1.1402986805480746e-05 1.459274100037023e-06 0.02389737488788973 0.007965319876920462 5.437264490952568e-11 10.26461954061106 -0.6065455780478457 MVVNEGSDGGQSVYHVHLHVLGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MVVNEGSDGGQSVYHVHLHVLGGR 24 0 P49773 P49773 HINT1 Histidine triad nucleotide-binding protein 1 0 3131206300.0 900577700.0 1230321900.0 1000306700.0 False True 1165815585.690436 1161853404.7251308 818261144.6134886 1.0 0.9966013655899457 0.7018787144871513 30.118692448140806 -6.909418794406502 0.8996849126395141 1.0092937769920747 0.6642606491826355 0.9907003555080164 0.013475927691379534 0.1048035742869801 0.14086173363318544 0.011001314731117172 0.0302476511644128 1.2319163113500013e-07 6.909418794406502 -0.3450331278094392 MVVPAALK(ub)VVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVVPAALKVVR 11 1 P40429;M0QYS1;Q8J015;Q6NVV1 P40429 RPL13A;RPL13a;RPL13AP3 60S ribosomal protein L13a;Putative 60S ribosomal protein L13a protein RPL13AP3 1 34028400.0 5537400.0 17649000.0 10842000.0 True False 7259585.024257882 15015837.995263161 9720173.843807723 1.0 2.0684154734861266 1.3389434535621239 22.791455651903874 -10.252321229108922 4.939265785302716 0.9998573114290769 1.7036794635247425 0.5537134148292322 0.2978057050773508 0.00046803114676696457 7.084823909552285e-05 0.28840682672700707 0.09611637801387024 5.593437257486588e-11 10.252321229108922 0.7038221520956657 MVVPAALK(ub)VVR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MVVPAALKVVR 11 1 P40429;M0QYS1;Q8J015;Q6NVV1 P40429 RPL13A;RPL13a;RPL13AP3 60S ribosomal protein L13a;Putative 60S ribosomal protein L13a protein RPL13AP3 1 96700300.0 18846000.0 33869400.0 43984900.0 True False 18247744.04577885 47393628.04658765 32463935.171284497 1.0 2.5972321799171096 1.7790656801104245 24.121214779977112 -10.293182311915885 5.5603307095875465 0.9998604496969027 2.1881489300137913 0.7376624029005925 0.3340150748609678 0.0005778944029653434 7.346158114429964e-05 0.32344564575179713 0.10780290185988345 5.0911710458458444e-11 10.293182311915885 1.1882884803168885 MVVPAALK(ub)VVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MVVPAALKVVR 11 1 P40429;M0QYS1;Q8J015;Q6NVV1 P40429 RPL13A;RPL13a;RPL13AP3 60S ribosomal protein L13a;Putative 60S ribosomal protein L13a protein RPL13AP3 1 70669600.0 21232000.0 8528600.0 40909000.0 True False 32210496.26711793 7006604.695744062 32823318.218948327 1.0 0.21752551210757815 1.0190255358609919 24.94102755270608 -9.192425750299089 12.716412279106311 0.9999893664424792 0.6182755239827087 0.23220721044515646 0.3272110145616709 0.0 0.0 0.3168207024972222 0.10560690083240738 6.420579823734702e-10 9.192425750299089 -0.38171384245977047 MVVPAALK(ub)VVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVVPAALKVVR 11 1 P40429;M0QYS1;Q8J015;Q6NVV1 P40429 RPL13A;RPL13a;RPL13AP3 60S ribosomal protein L13a;Putative 60S ribosomal protein L13a protein RPL13AP3 1 33668400.0 5537400.0 16149000.0 11982000.0 True False 7584726.42260832 15435483.782398352 9152098.377036095 1.0 2.0350745593656137 1.2066484494095662 22.854665713426765 -10.157708882678687 4.569052207613699 0.9999119954656104 1.6208615043978603 0.4282102232265155 0.3382035432002838 39843039.93281548 88577280.92756763 21771.48129491646 0.11577608040687229 6.954903641437297e-11 10.157708882678687 0.6209495089322499 MVVPAALK(ub)VVR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MVVPAALKVVR 11 1 P40429;M0QYS1;Q8J015;Q6NVV1 P40429 RPL13A;RPL13a;RPL13AP3 60S ribosomal protein L13a;Putative 60S ribosomal protein L13a protein RPL13AP3 1 73187600.0 18846000.0 37508400.0 16833200.0 True False 15671284.019359998 37306334.804365546 20352944.292077012 1.0 2.3805538051813766 1.29874133267787 23.90162005541139 -6.584903268154259 2.2476433457204448 1.9373371493505895 1.3016232630383386 0.0 0.5990143276360824 0.6848056704927841 6.513993488525338 0.22310361200261392 0.6687991507039776 2.6007387698028653e-07 6.584903268154259 -0.6357138863122509 MVVPAALK(ub)VVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVVPAALKVVR 11 1 P40429;M0QYS1;Q8J015;Q6NVV1 P40429 RPL13A;RPL13a;RPL13AP3 60S ribosomal protein L13a;Putative 60S ribosomal protein L13a protein RPL13AP3 1 41781000.0 21232000.0 8784000.0 11765000.0 True False 27485242.54528994 8295162.678243429 9623890.71909414 1.0 0.3018042378405333 0.350147563851255 24.712153874798528 -10.01219272440094 7.425715875159608 1.0000000311529558 0.3259759008458942 0.9961566393610574 0.01973608019921466 1.018170516495847e-08 1.380482369062489e-09 0.019109378336993183 0.006369792494247655 9.723156490201829e-11 10.01219272440094 -0.6740241303070615 MVVSFNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MVVSFNR 7 0 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2;P46940;H0YLE8;A0A0J9YXZ5 Q13576;P46940 IQGAP2;IQGAP1 Ras GTPase-activating-like protein IQGAP2;Ras GTPase-activating-like protein IQGAP1 0 32612100.0 11463000.0 6219100.0 14930000.0 False True 15028104.0078499 5291234.521861927 13385186.818672705 1.0 0.35208929343968215 0.8906770149901132 23.841159670071626 -10.248638050484534 7.892937803471845 1.0000004443721147 0.6213831542149441 0.3971943267906686 0.21987751658779056 1.7192035697691156e-06 1.6358493797125303e-07 0.2128957374200952 0.07096516332916318 5.64107598274769e-11 10.248638050484534 -0.3786172901571706 MVVSFNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MVVSFNR 7 0 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2;P46940;H0YLE8;A0A0J9YXZ5 Q13576;P46940 IQGAP2;IQGAP1 Ras GTPase-activating-like protein IQGAP2;Ras GTPase-activating-like protein IQGAP1 0 11569700.0 4723500.0 1199900.0 5646300.0 False True 4573555.078013178 1679026.3273958361 4167364.6446308563 1.0 0.36711623644100305 0.9111871560626801 22.124884594460557 -10.351573467482021 8.351749296251358 1.0000013862093748 0.6391516962518603 0.36968653360735626 0.22211602282665147 5.733240252119767e-06 4.4511222081591476e-07 0.2150637409910972 0.07168763811112064 4.450681665377598e-11 10.351573467482021 -0.36084968995751454 MVVSFNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVVSFNR 7 0 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2;P46940;H0YLE8;A0A0J9YXZ5 Q13576;P46940 IQGAP2;IQGAP1 Ras GTPase-activating-like protein IQGAP2;Ras GTPase-activating-like protein IQGAP1 0 26476200.0 11463000.0 7110400.0 7902800.0 False True 15701180.875927169 6796239.017051531 6036321.403274984 1.0 0.43284890931174674 0.38445015384351044 23.904369731594517 -13.999999999999998 0.3485678492925547 7.913391553220726 0.37763615782031396 0.999751971059362 0.0044012666968062586 20.518077769515916 0.18995261259079343 104.95836905084529 0.014511406774124923 1.0000000000000041e-14 13.999999999999998 -7.535755395400412 MVVSFNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MVVSFNR 7 0 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2;P46940;H0YLE8;A0A0J9YXZ5 Q13576;P46940 IQGAP2;IQGAP1 Ras GTPase-activating-like protein IQGAP2;Ras GTPase-activating-like protein IQGAP1 0 9909400.0 4723500.0 3183000.0 2002900.0 False True 3927799.5365301347 3165852.547223969 2421697.129636734 1.0 0.8060117421421973 0.6165531379883227 21.905289869894833 -6.971415687221524 0.22180055895554598 1.0854076282548182 0.3317963415142286 0.999991414019947 0.00045866985496751555 0.07584609701232728 0.007365209705792122 0.0051762602428593735 0.01913004386517581 1.0680321173353344e-07 6.971415687221524 -0.7536112867405895 MVVSFNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVVSFNR 7 0 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2;P46940;H0YLE8;A0A0J9YXZ5 Q13576;P46940 IQGAP2;IQGAP1 Ras GTPase-activating-like protein IQGAP2;Ras GTPase-activating-like protein IQGAP1 0 16199600.0 3812600.0 6381000.0 6006000.0 False True 4935485.857581586 6025891.740650202 4912969.626764083 1.0 1.2209318220198329 0.9954378897099028 22.234760682338436 -6.6508576465130655 2.004998622574057 1.1432707638139417 0.9963801906333077 0.19748175772978316 0.09427758858130825 0.506607911015624 3.90447429800296 0.03811698745142804 0.1044587712004041 2.2343044654062165e-07 6.6508576465130655 -0.14689057318063392 MVYIYHSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MVYIYHSLK 9 0 Q8IUF8-4;Q8IUF8;Q8IUF8-3 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 0 16591900.0 4456000.0 6392000.0 5743900.0 False True 6760077.777236123 5251297.659076051 4608615.647359195 1.0 0.7768102427399969 0.681740033062673 22.688608414675915 -13.999999999487816 0.11660859251014814 2.067002420668479 0.5228290839001596 0.999709730963813 0.0022726341899948444 11.978022746025353 0.1046404213731813 2.9759440817941956 0.14100993587633912 1.0000000011793474e-14 13.999999999487816 -1.5441733367683197 MVYIYHSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MVYIYHSLK 9 0 Q8IUF8-4;Q8IUF8;Q8IUF8-3 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 0 10034700.0 5828800.0 4205900.0 0.0 False True 7983864.877397214 4020069.4309486193 0.0 1.0 0.5035242320207184 0.0 22.92865587337127 -7.91782209546718 0.5951126383912164 1.0100175563014833 2.513126210189488e-18 0.9889147501431854 0.04298339453380591 0.11270178007887877 0.16109548730534332 0.04469909990871945 0.07710332142537607 1.2083087057115891e-08 7.91782209546718 -1.0100175563014833 down MVYIYHSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MVYIYHSLK 9 0 Q8IUF8-4;Q8IUF8;Q8IUF8-3 Q8IUF8-4 MINA Bifunctional lysine-specific demethylase and histidyl-hydroxylase MINA 0 19577100.0 4456000.0 8414000.0 6707100.0 False True 5768379.840891666 7945753.50349956 5486476.620657575 1.0 1.3774671090784687 0.9511295670517921 22.459734736768365 -6.673067252951366 1.9268758821225493 1.2402989800308644 0.952840673748502 0.292615363407561 0.16022743395355726 0.45406715112616125 3.2531953930207833 0.06688051938193279 0.17795195683849782 2.122915691069899e-07 6.673067252951366 -0.28745830628236235 MWDPHNDPNAQGDAFK(ub)TLFVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MWDPHNDPNAQGDAFKTLFVAR 22 1 P08621-2;P08621;P08621-3;M0QYR1 P08621-2 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 1 13289200.0 3070100.0 5222700.0 4996400.0 True False 4024930.8308906904 4443493.517925156 4479420.456853065 1.0 1.1039925167960813 1.1129186177497115 21.94053255980896 -13.686923663891397 0.35079973794372743 1.6696333354570907e-05 1.1141533170875157 0.999746486729597 0.0008160850774336512 16.590560811203826 0.19011449103983247 12.25023433672058 0.0026570936042640187 2.0562519924276743e-14 13.686923663891397 1.1141366207541612 MWDPHNDPNAQGDAFK(ub)TLFVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MWDPHNDPNAQGDAFKTLFVAR 22 1 P08621-2;P08621;P08621-3;M0QYR1 P08621-2 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 1 27454000.0 9145000.0 8582900.0 9726100.0 True False 8854696.980719917 12010096.7292322 7178542.633254362 1.0 1.3563532163080005 0.8107044937714766 23.07801150624007 -6.730466867140185 1.7213719714793365 1.2143377581637316 0.8109918216448602 0.5615004370657408 0.14979699565262922 0.33536239766014836 1.9469722964342548 0.068953132901472 0.17102233826823163 1.860086466092261e-07 6.730466867140185 -0.4033459365188714 MWDPHNDPNAQGDAFK(ub)TLFVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MWDPHNDPNAQGDAFKTLFVAR 22 1 P08621-2;P08621;P08621-3;M0QYR1 P08621-2 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 1 49444000.0 15124000.0 16785000.0 17535000.0 True False 22944213.712504275 13789585.608196424 14069199.564136462 1.0 0.6010049322667045 0.6131916194830832 24.451627031323117 -10.06438135885562 5.1908392658126115 1.0000054655993327 0.6070982758740094 0.9992789721205593 0.004975194225590039 3.146958736885235e-07 5.672649329261365e-08 0.004817278045665567 0.0016057370312108138 8.622210892400672e-11 10.06438135885562 -0.39290718972532324 MWDPHNDPNAQGDAFK(ub)TLFVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MWDPHNDPNAQGDAFKTLFVAR 22 1 P08621-2;P08621;P08621-3;M0QYR1 P08621-2 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 1 14787100.0 3070100.0 5057000.0 6660000.0 True False 4205198.936332898 4833565.018737293 5087045.16700554 1.0 1.149426006217046 1.2097038080775429 22.003742621331853 -13.99999999999991 0.12506715586039818 0.28963882142415687 1.299656025922675 0.9996684809938409 0.0016050344993520141 11.94731706729258 0.10945988169012957 2.096553525139634 0.07988126308872726 1.0000000000002086e-14 13.99999999999991 1.010017204498518 MWDPHNDPNAQGDAFK(ub)TLFVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MWDPHNDPNAQGDAFKTLFVAR 22 1 P08621-2;P08621;P08621-3;M0QYR1 P08621-2 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 1 24389800.0 9145000.0 8925000.0 6319800.0 True False 7604472.692191827 8876919.253526203 7641240.960546313 1.0 1.16732870415077 1.0048350845407386 22.858416781674347 -10.863816604384269 2.6110137541522622 0.9620406239113599 1.0860818942774317 0.2722974409392481 0.06633774410610006 22426297.711261913 13754744.952527467 5279451.781237584 0.024351864274132003 1.3683065175766083e-11 10.863816604384269 0.12404127036607182 MWDPHNDPNAQGDAFK(ub)TLFVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MWDPHNDPNAQGDAFKTLFVAR 22 1 P08621-2;P08621;P08621-3;M0QYR1 P08621-2 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 1 40715000.0 15124000.0 13518000.0 12073000.0 True False 19578316.13860985 12765711.416722966 9875837.879441015 1.0 0.6520331639526478 0.5044273373421094 24.222753353415566 -13.999999999999998 0.11726200112303052 2.662403989711378 0.2599075448733347 0.9997064756920511 0.003559374903984777 11.975049257041821 0.10502395681953419 4.656893220680116 0.2169700856160283 1.0000000000000041e-14 13.999999999999998 -2.4024964448380435 MWNK(ub)ELYVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MWNKELYVR 9 1 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 45750000.0 13205000.0 17815000.0 14730000.0 True False 17311882.877401885 15157071.442326097 13205880.900137229 1.0 0.8755299206715073 0.7628217562270805 24.045259308047413 -6.972307014639829 0.19539807443967722 1.0712026400879142 0.5640525735104133 0.9999952234248687 0.00021162838120616486 0.07556111941022389 0.006273839417011348 0.0038017001737236586 0.012108423497258564 1.0658423817298051e-07 6.972307014639829 -0.507150066577501 MWNK(ub)ELYVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MWNKELYVR 9 1 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 35549400.0 8473400.0 15775000.0 11301000.0 True False 8204416.55510466 22074039.765538227 8340929.077267112 1.0 2.6905069504063763 1.0166389067699781 22.967969311596285 -6.64388879642768 2.030517931741808 2.1022164481585923 1.0236506151076594 0.16967339996316988 0.7226176290702764 0.5236077903071814 4.130694203882326 0.2893407366033168 0.8001772621327732 2.2704461381075845e-07 6.64388879642768 -1.078565833050933 MWNK(ub)ELYVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MWNKELYVR 9 1 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 33615900.0 13205000.0 11037000.0 9373900.0 True False 18087245.35170707 10549348.845521746 7159977.881530507 1.0 0.5832479540355271 0.3958578402794071 24.108469369570305 -13.999999999999998 0.1079612811033259 3.0185091916460696 0.04178400317070426 0.9997534254707643 0.003964852302294904 12.025030532165907 0.0993665631574512 5.311623699474752 0.3146723987012178 1.0000000000000041e-14 13.999999999999998 -2.976725188475365 MWNK(ub)ELYVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MWNKELYVR 9 1 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 36941800.0 8473400.0 19062000.0 9406400.0 True False 7046007.535267162 18959309.222489245 11373234.749720389 1.0 2.690787531462719 1.6141388854318266 22.74837458703056 -10.475993251925033 4.957935187431189 0.9970917242986271 2.152463208447345 0.6043871754989287 0.43953996917259464 0.014149706603793475 0.001495488054970943 0.42618183293629175 0.14186091504979595 3.342002327946119e-11 10.475993251925033 1.1553714841487182 MWNK(ub)ELYVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MWNKELYVR 9 1 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 80796000.0 30827000.0 20997000.0 28972000.0 True False 39906159.19101606 19828498.492153592 23699393.277823716 1.0 0.49687814848935685 0.5938780819367623 25.25010809608701 -9.969917287645055 5.627240116695928 1.0000007263192825 0.5453781152126275 0.9669841248783773 0.039600057006537154 13148100.573085733 23294808.272945613 83.63899371838127 0.013556151910156885 1.07172339791901e-10 9.969917287645055 -0.45462261110665503 MWPVFWTVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MWPVFWTVVR 10 0 E5RH51;Q96EX1 E5RH51 SMIM12 Small integral membrane protein 12 0 9913500.0 2613500.0 2434800.0 4865200.0 False True 3964870.5724431323 2000290.9168207725 3903591.087507084 1.0 0.5045034586307325 0.9845443921014834 21.918842341295775 -10.806895473501203 10.32794889408246 1.0025880731890955 0.744523925366108 0.27412310166798426 0.19597589044211103 0.011752565825588857 0.0002197407839769034 0.19095259330614797 0.06325094666170548 1.559927902903271e-11 10.806895473501203 -0.2580641478229875 MWPVFWTVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MWPVFWTVVR 10 0 E5RH51;Q96EX1 E5RH51 SMIM12 Small integral membrane protein 12 0 9982500.0 2613500.0 4251300.0 3117700.0 False True 3383227.2697868855 4014711.417806954 2550310.5903034275 1.0 1.1866514122948195 0.7538100124335056 21.689968663388225 -6.789505631811272 1.4981962212443858 1.1043869922930627 0.7492620127683525 0.7997478499514216 0.07932443591750131 0.23609186111359518 1.0468877023743317 0.04167532767017023 0.09761207400709594 1.623657295205141e-07 6.789505631811272 -0.3551249795247102 MWSK(ub)LNNEEHNELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MWSKLNNEEHNELR 14 1 Q13546;Q13546-2 Q13546 RIPK1 Receptor-interacting serine/threonine-protein kinase 1 1 13452300.0 1367200.0 2912900.0 9172200.0 True False 2074142.3557085337 2393070.236408422 7359310.649681933 1.0 1.1537637374899186 3.5481222537244648 20.98408348412466 -6.919976636772283 0.8249164272511523 0.9471253104801255 3.9340058065556662 0.9941740856426351 0.08904722322910279 0.09818541768459488 0.10569088437888598 0.07671371222320052 0.2297370186693283 1.20232911315807e-07 6.919976636772283 2.986880496075541 up MWVQLLIPR ddPTM_RPMI8226_Bortezomib_1h_R1 2 MWVQLLIPR 9 0 P61289;P61289-3;P61289-2;K7ESG5;B3KQ25;K7EMD0;K7EPX6;K7EKR3 P61289 PSME3 Proteasome activator complex subunit 3 0 19852440.0 5698360.0 10526580.0 3627500.0 False True 7470605.142996742 8956055.296287471 3252161.097437055 1.0 1.1988393342784622 0.43532766558888025 22.83279368000135 -6.8375226885906875 1.2936694730487022 1.1058444020060973 0.41139583841714134 0.920128263420725 0.0914005953823041 0.17172241382210973 0.5592994165424974 0.0554186390800306 0.1276143083074593 1.4537084383905728e-07 6.8375226885906875 -0.694448563588956 down MWVQLLIPR ddPTM_RPMI8226_Bortezomib_2h_R1 2 MWVQLLIPR 9 0 P61289;P61289-3;P61289-2;K7ESG5;B3KQ25;K7EMD0;K7EPX6;K7EKR3 P61289 PSME3 Proteasome activator complex subunit 3 0 31748900.0 13000900.0 8622200.0 10125800.0 False True 12588193.545832874 12065089.424179 7473549.212511397 1.0 0.9584448618660587 0.5936951307032771 23.58556792983743 -6.928412953734471 0.7597095682078567 1.0058857442484717 0.5217538037707685 0.9962169416331033 0.011226756267258282 0.09347048408653352 0.08178004357772757 0.010133144520309105 0.033296286730687435 1.1791988480749253e-07 6.928412953734471 -0.48413194047770314 MWVQLLIPR ddPTM_RPMI8226_Bortezomib_8h_R1 2 MWVQLLIPR 9 0 P61289;P61289-3;P61289-2;K7ESG5;B3KQ25;K7EMD0;K7EPX6;K7EKR3 P61289 PSME3 Proteasome activator complex subunit 3 0 146906600.0 39233900.0 46588300.0 61084400.0 False True 59520694.68229452 38274253.86895065 49011041.56575641 1.0 0.6430411149138688 0.8234285877771452 25.82688802884385 -10.262982485608442 4.652090653686579 1.0000994153217704 0.7332348513445944 0.7446359170953534 0.07364287742076212 7.59624618487339e-05 1.2034452643281622e-05 0.0713309004864557 0.02376813648432693 5.4577987106380786e-11 10.262982485608442 -0.26686456397717595 MWVQLLIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MWVQLLIPR 9 0 P61289;P61289-3;P61289-2;K7ESG5;B3KQ25;K7EMD0;K7EPX6;K7EKR3 P61289 PSME3 Proteasome activator complex subunit 3 0 36571560.0 5698360.0 10884000.0 19989200.0 False True 7805197.684388769 10403108.891425084 15268162.65049656 1.0 1.3328437423477968 1.956153228640771 22.89600374152424 -6.961310603417926 0.41655142314974086 0.9714040979557396 2.340973229220092 0.9998157607026008 0.005379252621729294 0.0792362283147017 0.01942568963432084 0.00804705305972479 0.051936729499977644 1.0931742584548839e-07 6.961310603417926 1.3695691312643525 MWVQLLIPR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 MWVQLLIPR 9 0 P61289;P61289-3;P61289-2;K7ESG5;B3KQ25;K7EMD0;K7EPX6;K7EKR3 P61289 PSME3 Proteasome activator complex subunit 3 0 24620090.0 13000900.0 5925500.0 5693690.0 False True 10810824.387525072 5893578.155380346 6884214.25435188 1.0 0.545155294741548 0.6367890188185628 23.365973205271708 -9.924954193671194 5.634189732091622 1.000000358707807 0.5909721567794007 0.9637240414707614 0.03740931120566159 1.685579950567809e-07 3.209220562586595e-08 0.03622144166604294 0.012073803274038227 1.1886275889076538e-10 9.924954193671194 -0.4090282019284063 MWVQLLIPR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 MWVQLLIPR 9 0 P61289;P61289-3;P61289-2;K7ESG5;B3KQ25;K7EMD0;K7EPX6;K7EKR3 P61289 PSME3 Proteasome activator complex subunit 3 0 138276600.0 39233900.0 49578000.0 49464700.0 False True 50789056.965789855 46818940.717435464 40462632.15068218 1.0 0.9218312667032083 0.7966801230024161 25.5980143509363 -6.964151273919478 0.37233175166698096 1.0093733657244528 0.7047656965072405 0.9998945614536903 0.0008598547348907723 0.07825016811269714 0.015882752127422874 0.0016439721894872352 0.010615874245400099 1.086047264578292e-07 6.964151273919478 -0.3046076692172123 MYDLNSNNPNPIISYDGVNK(ub)NIASVGFHEDGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGR 32 1 A0A0A0MR05;Q9BVC4-3;Q9BVC4-5;Q9BVC4;H3BSZ4;H3BM50;H3BPU5;H3BR25;H3BPT1;H3BN58;Q9BVC4-4 A0A0A0MR05 MLST8 Target of rapamycin complex subunit LST8 1 97505300.0 5894300.0 15991000.0 75620000.0 True False 8942084.031050919 13137281.11174675 60673673.85457665 1.0 1.4691520529362316 6.785182698338608 23.092179672642754 -6.924236827364303 0.7926576687224968 0.8996304503549137 7.7319857972134285 0.995279460424427 0.18025627820130477 0.09574246895218823 0.09315912640727346 0.1589028232570982 0.49711842886498 1.1905925827895751e-07 6.924236827364303 6.832355346858515 up MYDLNSNNPNPIISYDGVNK(ub)NIASVGFHEDGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGR 32 1 A0A0A0MR05;Q9BVC4-3;Q9BVC4-5;Q9BVC4;H3BSZ4;H3BM50;H3BPU5;H3BR25;H3BPT1;H3BN58;Q9BVC4-4 A0A0A0MR05 MLST8 Target of rapamycin complex subunit LST8 1 17159900.0 2482700.0 3733200.0 10944000.0 True False 2064475.052258572 3713088.5106178196 13232339.800661255 1.0 1.7985630325518516 6.409542118799083 20.977343553980038 -6.93665238006912 0.6900021513729501 0.944043629900076 7.539386419100795 0.9976917572897359 0.11454948475606981 0.08932753802016746 0.061815998051245984 0.1088569517831871 0.40305743297917496 1.1570379931692668e-07 6.93665238006912 6.5953427892007195 MYDLNSNNPNPIISYDGVNK(ub)NIASVGFHEDGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MYDLNSNNPNPIISYDGVNKNIASVGFHEDGR 32 1 A0A0A0MR05;Q9BVC4-3;Q9BVC4-5;Q9BVC4;H3BSZ4;H3BM50;H3BPU5;H3BR25;H3BPT1;H3BN58;Q9BVC4-4 A0A0A0MR05 MLST8 Target of rapamycin complex subunit LST8 1 117314300.0 5894300.0 13436000.0 97984000.0 True False 7630287.544023286 12688274.788806783 80151917.40074131 1.0 1.6628829143857573 10.504442583362847 22.863305994735203 -6.921927516797426 0.8103219173339753 0.8181300046594003 11.995316457845414 0.9946993380535974 0.3154416726071613 0.09705113510012227 0.09984087656761402 0.2745953281987047 0.8383060220505344 1.196940282464751e-07 6.921927516797426 11.177186453186014 up MYEEHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MYEEHLK 7 0 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 0 4743510.0 1664500.0 631110.0 2447900.0 False True 1611661.3586012353 883115.5141951714 1806721.5545741236 1.0 0.5479535198148756 1.1210305098722362 20.620117206744254 -6.696394769726791 1.843545152348131 0.7183153255298732 1.1192256201719253 0.4005754884138826 0.19094267769362033 0.4030665976709168 2.6606118984983915 0.08270596099653797 0.21366394531126046 2.0118946245505153e-07 6.696394769726791 0.4009102946420521 MYEEHLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 2 MYEEHLKR 8 1 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 1 32526960.0 12578600.0 17034600.0 2913760.0 True False 16490666.411335662 14493104.080350725 2612272.06595953 1.0 0.8788670948063193 0.1584091267629947 23.975146365528005 -6.956582139063225 0.7092348315635987 1.0078421623785838 2.1877107404679965e-18 0.9976026613059455 0.018188866212686398 0.08529135551982213 0.06407190171394463 0.017262147242163097 0.0597266287047694 1.1051414318045933e-07 6.956582139063225 -1.0078421623785838 down MYEEHLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 2 MYEEHLKR 8 1 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 1 39232470.0 20239900.0 17059800.0 1932770.0 True False 19597395.45326112 23871867.105681736 1426519.5551428683 1.0 1.2181142725121323 0.07279128282863156 24.22415859322813 -6.857398323226685 1.198797694394609 1.117618344120703 0.02001967197942958 0.950398425393796 0.11058862790830853 0.149508562096462 0.4097645843442646 0.07202160884717942 0.1676593467023899 1.3886783884563586e-07 6.857398323226685 -1.0975986721412734 down MYEEHLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 MYEEHLKR 8 1 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 1 18635500.0 11943600.0 4818400.0 1873500.0 True False 18119314.394119684 3958518.8736689654 1503201.9038157808 1.0 0.21846957272034728 0.08296130146644067 24.11102503135525 -13.999999999999998 0.24649792325766406 6.340704619297057 0.026631237030337523 0.999536231117658 0.008703715852759131 13.861876277982537 0.15711294067336745 36.58097840076381 0.06377778944102624 1.0000000000000041e-14 13.999999999999998 -6.314073382266719 MYEEHLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 2 MYEEHLKR 8 1 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 1 28592930.0 12578600.0 14063600.0 1950730.0 True False 17229248.343883578 13442223.649893945 1490007.7505454537 1.0 0.7801979158693806 0.08648129743131887 24.038356427050896 -7.198217146025538 0.6946246871478845 0.9970521430041509 5.7981362241904e-20 0.996170847148487 0.024090662921428883 0.08796942593737236 0.07553385341112538 0.022035827994177585 0.057260808705981305 6.335528573948653e-08 7.198217146025538 -0.9970521430041509 down MYEEHLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MYEEHLKR 8 1 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 1 39191610.0 16531700.0 21756300.0 903610.0 True False 13746841.028486352 21639094.493612595 1092550.673179414 1.0 1.574113969076374 0.07947648997434528 23.712596795129762 -6.802581085257264 1.4453748702965807 1.3157345461536076 0.05751093451465442 0.8395955558456425 0.24655974600391728 0.21709445571455488 0.8951027434452664 0.13418296188562187 0.3115792181341993 1.5755018401007748e-07 6.802581085257264 -1.2582236116389531 down MYEEHLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MYEEHLKR 8 1 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 1 22269000.0 11943600.0 9232100.0 1093300.0 True False 15461225.643553337 8718325.519331872 894330.6182053231 1.0 0.5638832082479204 0.05784344907858067 23.8821513534477 -7.744480796125542 0.5360210867726343 1.0136555584218951 2.4483331746470347e-20 0.9937502608167575 0.030435238014479383 0.11480395659574372 0.11069896440210908 0.03365014704452988 0.076647629953333 1.8010227713057637e-08 7.744480796125542 -1.0136555584218951 down MYIALTGLQHAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MYIALTGLQHAGR 13 0 Q9H845;H0Y8Z9 Q9H845 ACAD9 Acyl-CoA dehydrogenase family member 9, mitochondrial 0 16253600.0 8180700.0 3957000.0 4115900.0 False True 10724976.922011496 3366631.02426519 3690026.1505006636 1.0 0.3139056660677429 0.34405912267535116 23.354471207550773 -10.00692629414322 5.083049925987388 1.0000055319971584 0.32898239436695764 0.9984877955920636 0.012310097131961462 33959708.87973343 5.897040932760674 2388.895559546389 0.00421407367454234 9.841781204008725e-11 10.00692629414322 -0.6710231376302007 MYIALTGLQHAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 MYIALTGLQHAGR 13 0 Q9H845;H0Y8Z9 Q9H845 ACAD9 Acyl-CoA dehydrogenase family member 9, mitochondrial 0 13120200.0 5529000.0 2292000.0 5299200.0 False True 5353484.921421583 3207207.5526221027 3911180.5474076536 1.0 0.5990878090995818 0.7305858902781901 22.35204690795586 -10.91776751255293 11.185334154701579 1.0403142341002107 0.6648368496888859 0.8965005306861974 0.053683866840445106 0.029112937804693276 0.00021403254368254643 0.02803898245023751 0.0173263935194217 1.2084605776739115e-11 10.91776751255293 -0.37547738441132483 MYIALTGLQHAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 MYIALTGLQHAGR 13 0 Q9H845;H0Y8Z9 Q9H845 ACAD9 Acyl-CoA dehydrogenase family member 9, mitochondrial 0 15406700.0 4523500.0 5888300.0 4994900.0 False True 6862480.212147126 4837486.859502114 4007655.825657562 1.0 0.7049181505746835 0.583995246873528 22.710298653459734 -13.999999999999998 0.12264273399575278 2.4041183768933614 0.39769246946589626 0.9996800785455667 0.0031251650911256704 11.954372963514823 0.10811023670012357 4.077510869860074 0.16536860659523533 1.0000000000000041e-14 13.999999999999998 -2.0064259074274653 MYIALTGLQHAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MYIALTGLQHAGR 13 0 Q9H845;H0Y8Z9 Q9H845 ACAD9 Acyl-CoA dehydrogenase family member 9, mitochondrial 0 21414680.0 8180700.0 5485700.0 7748280.0 False True 11205325.865104903 5243323.635215964 5918295.844835681 1.0 0.4679313835525726 0.5281681154196648 23.417681269073665 -10.116969416176493 5.173821784114003 1.0000135524497213 0.49804974948721126 0.9893144448650203 0.024591542810154906 3.844400047795233e-06 6.561139552015551e-07 0.023811301219498045 0.007936886313111187 7.638895762053867e-11 10.116969416176493 -0.5019638029625101 MYIALTGLQHAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MYIALTGLQHAGR 13 0 Q9H845;H0Y8Z9 Q9H845 ACAD9 Acyl-CoA dehydrogenase family member 9, mitochondrial 0 10008800.0 5529000.0 2028200.0 2451600.0 False True 4597608.476230571 2017273.6840338202 2964218.2250823365 1.0 0.43876587022645236 0.6447304594132387 22.132452183390136 -10.127578206859882 5.20031658781321 1.000013311735826 0.541748164819383 0.8684258160621647 0.08408469143321157 1.2977619739699686e-05 2.177172525038029e-06 0.08141701478536954 0.027138217465752502 7.454556198205783e-11 10.127578206859882 -0.45826514691644304 MYIALTGLQHAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MYIALTGLQHAGR 13 0 Q9H845;H0Y8Z9 Q9H845 ACAD9 Acyl-CoA dehydrogenase family member 9, mitochondrial 0 17363600.0 4523500.0 6414700.0 6425400.0 False True 5855759.921515584 6057716.306025521 5256043.1301714815 1.0 1.0344885014441758 0.897585147037776 22.481424975552184 -6.839946720885495 1.2825429765100262 1.0183479249447038 0.8930843153517651 0.9243758409182452 0.015988003071265702 0.16886306631818113 0.5395701870348792 0.009774636009557556 0.022519795664211077 1.445617107733496e-07 6.839946720885495 -0.1252636095929387 MYK(ub)LGDGVDKDEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MYKLGDGVDKDEAK 14 2 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 3442260.0 949660.0 1101800.0 1390800.0 True False 1245013.456520522 937415.7347827624 1246893.3574956441 1.0 0.7529362272136297 1.0015099443024302 20.24772990483079 -10.967156367528101 9.636751568890194 1.0592394185669562 0.8772230857580222 0.24544434404004867 0.10147979505575074 0.07060375866858958 0.0002406290576181563 0.05371188710534248 0.032752463018955374 1.0785583178862297e-11 10.967156367528101 -0.18201633280893403 MYK(ub)LGDGVDKDEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MYKLGDGVDKDEAK 14 2 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 7948900.0 1330000.0 1380400.0 5238500.0 True False 1287779.8780051917 1931600.918690903 3866379.698368616 1.0 1.499946498374403 3.0023607018598164 20.296454581992542 -6.951412587825016 0.5431202394294657 0.9783232443679968 3.593736755348637 0.9993074894332952 0.022392568358095014 0.08292354932986659 0.03365369515832944 0.024525079498629258 0.12448471212620534 1.1183749016899806e-07 6.951412587825016 2.6154135109806402 MYK(ub)LGDGVDKDEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MYKLGDGVDKDEAK 14 2 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 44208000.0 2064800.0 7725200.0 34418000.0 True False 3132452.557099895 6346577.70273691 27615267.214054693 1.0 2.0260730488485783 8.815861281430426 21.57886122854249 -6.933799846138422 0.7149138214309139 0.9098707953755135 10.354987819548603 0.9972337468387087 0.18239884528138578 0.0907123973781752 0.06836276532579093 0.17010331735222178 0.602039961965333 1.1646626653352208e-07 6.933799846138422 9.44511702417309 MYK(ub)LGDGVDKDEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MYKLGDGVDKDEAK 14 2 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 3320960.0 949660.0 1069200.0 1302100.0 True False 1300774.9655965285 1021959.2086284173 994570.7975912783 1.0 0.7856541182430831 0.7645986614872876 20.310939966353683 -13.999999999999998 0.32807061230296425 3.306367489838657 0.7607849949608092 0.9997108204675029 0.0018085766806551586 18.661658014118526 0.18305671739718085 29.66820688491826 0.00679623964978349 1.0000000000000041e-14 13.999999999999998 -2.5455824948778476 MYK(ub)LGDGVDKDEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MYKLGDGVDKDEAK 14 2 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 7019800.0 1330000.0 1882800.0 3807000.0 True False 1105953.9289901718 1872656.9826934622 4603026.09842081 1.0 1.6932504452544006 4.162041453773537 20.076859857426818 -6.947546342994109 0.5851614739219069 0.9710248708136185 5.007464929156216 0.9989943969780104 0.04303344402457507 0.08448622987354051 0.04015715509928436 0.04483993226714656 0.2065301743603145 1.1283755236322512e-07 6.947546342994109 4.036440058342597 MYQPLLAVGTSNGSVLVYHLTSGLLHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MYQPLLAVGTSNGSVLVYHLTSGLLHK 27 0 S4R3Z0;Q9BZH6 S4R3Z0 WDR11 WD repeat-containing protein 11 0 22708500.0 7801100.0 6952800.0 7954600.0 False True 11834839.036803586 5712018.517525655 6382369.82337497 1.0 0.48264437731367626 0.5392865761441529 23.496536748620827 -10.141350637820768 5.021638202298218 1.0000238513561333 0.5109654767278987 0.9900387315147514 0.023124080844181605 6.1751331277185406e-06 1.0558892429357614e-06 0.022390885261200123 0.007463264999984379 7.221864939806126e-11 10.141350637820768 -0.48905837462823454 MYSNVYYHITSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 MYSNVYYHITSK 12 0 A0A2R8Y4S6;S4R3K0;A0A2R8Y735;Q96JM3 A0A2R8Y4S6 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 0 20632600.0 8193900.0 5635000.0 6803700.0 False True 10742282.249840468 4794279.965057962 6099718.389698815 1.0 0.44629994386240973 0.5678233216958529 23.35679719764089 -9.833899302042369 6.532614800403224 1.0000000118879189 0.5070616327792635 0.9564049187924362 0.049611711252107955 8.552677238064872e-09 1.5340197526852042e-09 0.04803633357976863 0.016012110954657682 1.4658876905072232e-10 9.833899302042369 -0.49293837910865534 MYSNVYYHITSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 MYSNVYYHITSK 12 0 A0A2R8Y4S6;S4R3K0;A0A2R8Y735;Q96JM3 A0A2R8Y4S6 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 0 15880000.0 4802100.0 1702800.0 9375100.0 False True 4649659.964036642 2382736.919984691 6919480.063028659 1.0 0.5124540156515225 1.4881690524787223 22.148693783150094 -6.770859323657118 1.5711943902356311 0.7206552651116523 1.4938290610621012 0.7337852967179475 0.2055244152923319 0.26506451430972283 1.2915104310188643 0.10309846374073539 0.24522116142244604 1.6948867179746708e-07 6.770859323657118 0.7731737959504489 MYSNVYYHITSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 MYSNVYYHITSK 12 0 A0A2R8Y4S6;S4R3K0;A0A2R8Y735;Q96JM3 A0A2R8Y4S6 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 0 13493100.0 2935700.0 5145100.0 5412300.0 False True 4453671.528418338 4226916.706150221 4342556.532704639 1.0 0.9490858675092624 0.9750509225916892 22.086563728303783 -10.093003223117186 4.07872281627837 1.0000070654848747 0.9620683950372259 0.7399575441539168 0.01060018939834696 7373536.333845324 0.00468285337281661 524.8350668789537 0.0036287267723405727 8.072290393750112e-11 10.093003223117186 -0.03793867044764887 MYSNVYYHITSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MYSNVYYHITSK 12 0 A0A2R8Y4S6;S4R3K0;A0A2R8Y735;Q96JM3 A0A2R8Y4S6 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 0 16149300.0 8193900.0 3636700.0 4318700.0 False True 11223406.26182148 3476018.56904131 3298712.0064184433 1.0 0.3097115517296775 0.29391362385585473 23.420007259163782 MYSNVYYHITSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 MYSNVYYHITSK 12 0 A0A2R8Y4S6;S4R3K0;A0A2R8Y735;Q96JM3 A0A2R8Y4S6 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 0 9952400.0 4802100.0 3001200.0 2149100.0 False True 3993158.9191005304 2985031.939908444 2598466.8736843118 1.0 0.7475364743511962 0.6507296419521473 21.92909905858437 -13.999999999999998 0.13277953156324968 2.200571507688128 0.5198251783992776 0.9996332184524366 0.002819741485313224 11.933392205453478 0.11358170580864173 3.7302465713613904 0.11655088879430234 1.0000000000000041e-14 13.999999999999998 -1.6807463292888505 MYSNVYYHITSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 MYSNVYYHITSK 12 0 A0A2R8Y4S6;S4R3K0;A0A2R8Y735;Q96JM3 A0A2R8Y4S6 CHAMP1 Chromosome alignment-maintaining phosphoprotein 1 0 14725000.0 2935700.0 7510600.0 4278700.0 False True 3800321.5212984043 7092628.507651987 3500020.503169417 1.0 1.8663232749919392 0.9209801022239856 21.857690050396233 -6.665682386464456 1.952804428403583 1.5550080135320616 0.9248727675059776 0.26005302634323124 0.36836478767621267 0.47108136708179177 3.459113838499297 0.15209267972971408 0.4086364801743851 2.159323014273796e-07 6.665682386464456 -0.6301352460260841 MYSTDDGVQFHAFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 MYSTDDGVQFHAFGR 15 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 11429000.0 2654900.0 4583700.0 4190400.0 False True 3480599.610088174 3899829.827122661 3756817.605155126 1.0 1.1204476998214299 1.079359313339679 21.730904432864854 -10.11312678278072 4.476877548618036 0.9999893055977137 1.0999035065847185 0.8874186212068608 0.01677426355322977 1.7907212894687397e-06 3.5470785319352466e-07 0.016243349253439003 0.0054138702802295395 7.706784534936537e-11 10.11312678278072 0.09991420098700476 MYSTDDGVQFHAFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 MYSTDDGVQFHAFGR 15 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 9288400.0 2654900.0 3849900.0 2783600.0 False True 3636488.2759747957 3679798.688083186 2126171.010041536 1.0 1.0119099551054596 0.5846769874355212 21.794114494387745 -6.90048604714983 0.9581713775743551 1.0175266676411812 0.5393834186633641 0.986807108339944 0.022817214462049994 0.11104902580541937 0.1754009229516425 0.01784333162200371 0.04654050068963605 1.2575172547612205e-07 6.90048604714983 -0.478143248977817 NAAQFLLSTNDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAAQFLLSTNDK 12 0 P63151-2;P63151 P63151-2 PPP2R2A Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform 0 19201900.0 7667400.0 5506800.0 6027700.0 False True 10052035.651207227 4685206.905338275 5404011.425781205 1.0 0.4660953331154961 0.5376036867847952 23.260984357308427 -10.547382336907058 6.327460504499798 1.0006814596957625 0.5018495099503637 0.9847807494809286 0.029193163139376657 0.00028099802528972964 2.0100477218615953e-05 0.028302024689544323 0.009422052888493501 2.8354217282134013e-11 10.547382336907058 -0.4988319497453988 NAAQFLLSTNDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAAQFLLSTNDK 12 0 P63151-2;P63151 P63151-2 PPP2R2A Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform 0 20323600.0 7667400.0 6076100.0 6580100.0 False True 10502244.983693982 5807637.811024245 5026015.901413386 1.0 0.5529901292572504 0.478565859891565 23.32419441883132 -13.999999999999998 0.2522637652770732 4.144561440437024 0.4492788792675143 0.9995469893388964 0.004901237947082275 14.088824638846825 0.15892891657693853 22.48020081339418 0.033919348771653 1.0000000000000041e-14 13.999999999999998 -3.6952825611695097 NAAQVLVGIPLETGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAAQVLVGIPLETGQK 16 0 D6RFN0;Q9BT78;D6RAX7;Q9BT78-2 D6RFN0 COPS4 COP9 signalosome complex subunit 4 0 20085800.0 5940400.0 6526700.0 7618700.0 False True 7787921.926915438 5552941.800877342 6830390.007730854 1.0 0.713019705768506 0.877049111666707 22.892806990591357 -10.17867556700596 5.134902745925148 1.000012423942972 0.7950344091207142 0.6755235080766904 0.06696472454428729 9.525014800613222e-06 1.5235951090360881e-06 0.064842244384226 0.021612771911871206 6.627113871511692e-11 10.17867556700596 -0.20497801482225775 NAAQVLVGIPLETGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAAQVLVGIPLETGQK 16 0 D6RFN0;Q9BT78;D6RAX7;Q9BT78-2 D6RFN0 COPS4 COP9 signalosome complex subunit 4 0 14700100.0 4144300.0 3643700.0 6912100.0 False True 4012741.4649751256 5098648.411644485 5101613.651444825 1.0 1.2706147296424666 1.2713536857467216 21.9361567777188 NAAQVLVGIPLETGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAAQVLVGIPLETGQK 16 0 D6RFN0;Q9BT78;D6RAX7;Q9BT78-2 D6RFN0 COPS4 COP9 signalosome complex subunit 4 0 16389700.0 5940400.0 4023600.0 6425700.0 False True 8136726.413273827 3845824.0477341064 4908082.001445572 1.0 0.47265003791453913 0.6032010604951379 22.956017052114248 -10.126670061970493 7.7705639014887575 1.0000000755867835 0.5379255492049106 0.9435133325010416 0.05329723178683862 6.978456779262172e-08 7.867289500880901e-09 0.05160483085145452 0.017201607592448546 7.470160587509001e-11 10.126670061970493 -0.46207452638187285 NAAQVLVGIPLETGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAAQVLVGIPLETGQK 16 0 D6RFN0;Q9BT78;D6RAX7;Q9BT78-2 D6RFN0 COPS4 COP9 signalosome complex subunit 4 0 8475500.0 4144300.0 1933400.0 2397800.0 False True 3446169.0736195263 1922984.3904501488 2899168.8938254337 1.0 0.5580063976461926 0.8412729706208013 21.716562053153076 -10.091919004825312 5.096913854736278 1.0000070669488323 0.6996396841327303 0.5998573736828676 0.11564309416510944 9.286941125325427e-06 1.6545268928642986e-06 0.11197357825923188 0.03732364815006418 8.092468082451262e-11 10.091919004825312 -0.3003673828161021 NAAYYSPHGHILVLAGFGNLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAAYYSPHGHILVLAGFGNLR 21 0 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;Q9BY44-2;H7C5R5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 9085000.0 2087100.0 4673900.0 2324000.0 False True 2736208.311505149 3976572.3387195067 2083534.773382137 1.0 1.4533149110025365 0.7614678913960371 21.383746638193912 -6.729912752221666 1.723368295292226 1.2728241873135104 0.7618712915110076 0.5589583476393118 0.19056389738245222 0.33639281600157017 1.9572294172183278 0.08762567816593643 0.21747359279240722 1.8624612590444208e-07 6.729912752221666 -0.5109528958025028 NAAYYSPHGHILVLAGFGNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAAYYSPHGHILVLAGFGNLR 21 0 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;Q9BY44-2;H7C5R5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 27362500.0 7656400.0 8970100.0 10736000.0 False True 7413351.772901474 12551907.708453534 7923919.52690378 1.0 1.693148806769884 1.068871378243323 22.82169454003747 -10.38238227550966 4.570874009232911 0.9994273573781921 1.3810100925071924 0.3318441701927076 0.2548601929731538 0.0014894393855623281 0.0002012533190785552 0.24712909395324203 0.08225577358273647 4.1458895170679504e-11 10.38238227550966 0.3815827351290003 NAAYYSPHGHILVLAGFGNLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NAAYYSPHGHILVLAGFGNLR 21 0 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;Q9BY44-2;H7C5R5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 178339000.0 34184000.0 36010000.0 108145000.0 False True 51859627.185152546 29583734.152585838 86770093.34836258 1.0 0.5704579025792859 1.6731723318906722 25.628108499016996 -6.8010629221708685 1.451521325944335 0.7633196568332674 1.6888047381821056 0.8352615887902202 0.18420000648186013 0.2192464526836765 0.9118497895405352 0.099826476640922 0.2320158416502937 1.5810189588740943e-07 6.8010629221708685 0.9254850813488382 NAAYYSPHGHILVLAGFGNLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAAYYSPHGHILVLAGFGNLR 21 0 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;Q9BY44-2;H7C5R5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 19267200.0 2087100.0 6436800.0 10743300.0 False True 2858757.2717567473 6152400.892348863 8205953.8052088 1.0 2.152124265019578 2.8704618913539743 21.446956699716804 -8.55260382810135 0.18367548074051313 5.189872899448214e-24 3.828314983452163 0.9997677097947785 0.01174213797313236 0.18373983248735654 0.04861134092710678 0.47782360403430185 0.38734659322610526 2.8015357699294785e-09 8.55260382810135 3.828314983452163 NAAYYSPHGHILVLAGFGNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAAYYSPHGHILVLAGFGNLR 21 0 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;Q9BY44-2;H7C5R5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 19957100.0 7656400.0 6871000.0 5429700.0 False True 6366635.836030345 6833984.559213281 6565025.165903725 1.0 1.0734059140838705 1.031160778625133 22.602099815471746 -10.23796669851887 3.5932540342946515 0.9999050650355851 1.052283346377622 0.6712974946118953 0.0172465045292748 8112698.256375959 6522267.476337617 7382.859279462345 0.006311574322055255 5.781403772177034e-11 10.23796669851887 0.052378281342036925 NAAYYSPHGHILVLAGFGNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAAYYSPHGHILVLAGFGNLR 21 0 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;Q9BY44-2;H7C5R5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 169564000.0 34184000.0 68032000.0 67348000.0 False True 44251861.867378995 64245959.39506571 55091355.048835725 1.0 1.4518250008916733 1.2449499913459516 25.399234821109445 -10.159107198496653 4.4999204044964545 0.999943726379775 1.348387496125483 0.7908543954088665 0.08445636901615987 4.8553544164728314e-05 9.073106000473657e-06 0.08178794669994141 0.027258175885908287 6.932546663090548e-11 10.159107198496653 0.3484437697457079 NADELVK(ub)QK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NADELVKQK 9 1 P17987;E7ERF2;F5H136;F5H676;F5H726 P17987 TCP1 T-complex protein 1 subunit alpha 1 23234100.0 2467600.0 4535500.0 16231000.0 True False 3743529.605724388 3726104.588976756 13022935.735699981 1.0 0.9953452974644608 3.478785292838626 21.835967733379047 -6.906475108568196 0.9194073292427156 0.9142757084416269 3.7766565254704685 0.9895219102695518 0.11972417536953153 0.1067953358307128 0.1517537568529239 0.09634249568555228 0.25988038873517094 1.2402947101263386e-07 6.906475108568196 2.862380817028842 up NADELVK(ub)QK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NADELVKQK 9 1 P17987;E7ERF2;F5H136;F5H676;F5H726 P17987 TCP1 T-complex protein 1 subunit alpha 1 18411000.0 2467600.0 2757400.0 13186000.0 True False 3194356.843667928 2603948.266050593 10786283.299785417 1.0 0.8151713767396767 3.3766682395445966 21.607094055471496 -6.889553825117789 1.024993669577865 0.8608924150126042 3.5950848561453 0.9806120656737789 0.16240740075819243 0.11950689959549583 0.22395593685472256 0.12079606801849099 0.3006740544528915 1.2895737222068732e-07 6.889553825117789 2.734192441132696 up NADGK(ub)IISLDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NADGKIISLDAK 12 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 5868500.0 1058700.0 1960300.0 2849500.0 True False 1387965.9524653854 1667830.8811895528 2554661.0743340836 1.0 1.2016367391628413 1.840579064490989 20.40454074760648 -6.950214089184258 0.5564888046613591 0.9914848050476023 2.0810835780297245 0.9992179735843519 0.010020057044634583 0.08339990069663213 0.03560754176311118 0.010787057668927052 0.05307382795281732 1.1214654820030889e-07 6.950214089184258 1.0895987729821224 NADGK(ub)IISLDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NADGKIISLDAK 12 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 2424600.0 1058700.0 1365900.0 0.0 True False 1450130.0002917317 1305550.0215727221 0.0 1.0 0.9002986086144529 0.0 20.46775080912937 -7.116426677438458 0.972172034811262 0.9981639249002642 7.706133667787665e-19 0.989623455573685 0.04581395960280301 0.08544408184820959 0.15325193835560208 0.037987365007335745 0.06694829829776963 7.648448073869152e-08 7.116426677438458 -0.9981639249002642 down NADGTICYDSTHYK(ub)ETWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NADGTICYDSTHYKETWK 18 1 P14550;Q5T621 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 1 30609800.0 5590100.0 6801700.0 18218000.0 True False 8480590.391051983 5587883.4930753345 14617204.31476693 1.0 0.6589026512789966 1.7236069236629792 23.01573327333364 -6.820501791249272 1.3696837841914709 0.8162424554533447 1.7471049704003596 0.8855362011675352 0.15018774206878593 0.19283110113897492 0.7106944719742021 0.08616353137299883 0.19856870647975997 1.5118134638674743e-07 6.820501791249272 0.9308625149470149 NADGTICYDSTHYK(ub)ETWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NADGTICYDSTHYKETWK 18 1 P14550;Q5T621 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 1 8040600.0 2454700.0 1534500.0 4051400.0 True False 3362268.92577322 1466700.7160870798 3094542.761202141 1.0 0.4362234992103682 0.92037336379644 21.68100369019899 -10.23897967450366 8.008623697389389 1.0000002586591021 0.678298431503407 0.37054993759659405 0.1976533545455746 9.129834537535253e-07 8.652846984013008e-08 0.191377191608922 0.0637923458730867 5.767934573778063e-11 10.23897967450366 -0.3217018271556952 NADGYK(ub)LDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NADGYKLDK 9 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 5596000.0 2128800.0 3467200.0 0.0 True False 2790877.4153285255 2949907.275039744 0.0 1.0 1.0569820296791854 0.0 21.412287327127817 -6.984561153967145 1.1459195128310131 1.0417274466381474 1.4455223823000512e-18 0.9806258149505545 0.0675624358699333 0.09577220033795217 0.24739946380791203 0.04951299658420149 0.09169638368090761 1.0361886861356337e-07 6.984561153967145 -1.0417274466381474 down NADGYK(ub)LDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NADGYKLDK 9 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 6970300.0 2640600.0 4329700.0 0.0 True False 2556775.598391362 6058571.789087219 0.0 1.0 2.369614209748822 0.0 21.28589411383233 -6.752090707849027 1.6557108204418867 1.8052894400316517 1.0588293452855544e-09 0.6488125641611698 0.5756062042554418 0.2984316284492447 1.6126185787783998 0.27521176642424044 0.6631372280712947 1.7697392874691017e-07 6.752090707849027 -1.8052894389728225 NADGYK(ub)LDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NADGYKLDK 9 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 15163400.0 3036500.0 4164800.0 7962100.0 True False 4606592.497885429 3421558.900269079 6388387.445087601 1.0 0.7427526749630409 1.3867923954680323 22.135268551185955 -6.798294907576048 1.4627539848823214 0.8577588326920821 1.395325545727909 0.8271761184363271 0.11003931086328764 0.22319109243108773 0.9429530622754144 0.05918508962280758 0.13779488875279347 1.5911279050594494e-07 6.798294907576048 0.5375667130358269 NADGYK(ub)LDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NADGYKLDK 9 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 5232600.0 2128800.0 3103800.0 0.0 True False 2915874.888656877 2966663.8531059516 0.0 1.0 1.0174180876712682 0.0 21.47549738865071 -7.010688234999489 1.1058077404551208 1.0275682922572966 6.264935730448049e-21 0.9845606772311056 0.05909113532218802 0.08990728247176538 0.21440940405634745 0.04502885334517157 0.08209729628598342 9.756898003665055e-08 7.010688234999489 -1.0275682922572966 down NADGYK(ub)LDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NADGYKLDK 9 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 7508600.0 2640600.0 4868000.0 0.0 True False 2195775.8984146235 4841775.11777765 0.0 1.0 2.205040651586289 0.0 21.066299389266607 -6.761852223143406 1.6284605347805972 1.7012837183256557 3.940734788065051e-09 0.6838815800883837 0.5068632920962711 0.28312072466504246 1.484001792465195 0.24649307905093268 0.5859162572686317 1.7304050618824183e-07 6.761852223143406 -1.7012837143849209 NADGYK(ub)LDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NADGYKLDK 9 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 10813400.0 3036500.0 4009200.0 3767700.0 True False 3930809.1083634496 3786084.495629958 3082017.259866643 1.0 0.963181978889393 0.7840668867152921 21.906394873278405 -6.94041835530493 0.6556608550750541 1.0019969536703741 0.735165089374284 0.9982181673785597 0.0039813724257220465 0.0875763349195006 0.053744600982697815 0.0038879586192982303 0.015387886341283545 1.1470481391591903e-07 6.94041835530493 -0.26683186429609007 NADHLLHLK(ub)TK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NADHLLHLKTK 11 1 Q969X6;H3BSH7;Q969X6-3;A0A0J9YWM9;A0A0J9YWK2;H3BRM8 Q969X6 CIRH1A Cirhin 1 29260900.0 2798200.0 4096700.0 22366000.0 True False 4245073.975821837 3365611.8773368043 17945350.296633955 1.0 0.7928276153739416 4.227335118031665 22.017358264120485 -6.892561312302313 1.007128856456473 0.8266304398340443 4.537971244516461 0.982486968860406 0.20809798658153703 0.11708880232345485 0.20991549361488568 0.15688737836964275 0.3948991230815703 1.28067428028501e-07 6.892561312302313 3.7113408046824166 up NADHLLHLK(ub)TK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NADHLLHLKTK 11 1 Q969X6;H3BSH7;Q969X6-3;A0A0J9YWM9;A0A0J9YWK2;H3BRM8 Q969X6 CIRH1A Cirhin 1 55387800.0 2798200.0 4622600.0 47967000.0 True False 3622325.060768189 4365348.246408028 39237498.18298246 1.0 1.205123276673095 10.832130613551655 21.788484586212935 -6.911499774795356 0.8854484910786131 0.7158798922899409 12.117060067420498 0.9914755741395554 0.4235379086472613 0.10343490764166609 0.1334455174610892 0.3493479953122399 0.9746939925230731 1.2260275384378405e-07 6.911499774795356 11.401180175130557 up NADHSMNYQYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NADHSMNYQYR 11 0 Q12906-7;Q12906;K7ELV3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 3676210.0 503010.0 1345700.0 1827500.0 False True 659450.9811557691 1144926.8054975155 1638407.8306178388 1.0 1.7361818212642435 2.4845028325628196 19.33090589832334 -6.970921506665564 0.2351394483672427 0.7145694492762024 3.5276303416178627 0.9999887042797764 0.002036880096012247 0.07600481259096893 0.007952395717921473 0.018520235420941486 0.07360130681545701 1.0692481150782737e-07 6.970921506665564 2.8130608923416602 NADHSMNYQYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NADHSMNYQYR 11 0 Q12906-7;Q12906;K7ELV3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 3489810.0 503010.0 1306600.0 1680200.0 False True 688986.3903341297 1248870.0916515987 1283371.3648052122 1.0 1.812619391576006 1.8626947974731847 19.394115959846232 -11.134722579818819 0.4819814963972076 3.496027904629638e-17 1.861355841261125 0.9997752428035511 0.0059278587255353204 3.1188106366232295 0.2352793460510641 3.400279273949728 0.010544234509766609 7.332927989573993e-12 11.134722579818819 1.861355841261125 NADMSEEMQQDSVECATQALEK(ub)YNIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NADMSEEMQQDSVECATQALEKYNIEK 27 1 P63167;F8VXL2;F8VRV5;F8VXI7 P63167 DYNLL1 Dynein light chain 1, cytoplasmic 1 106355000.0 19164000.0 31789000.0 55402000.0 True False 29073189.076066703 26116004.58140937 44451770.416440785 1.0 0.8982848256887059 1.5289609371760962 24.793185995468274 -6.865578035163888 1.1573141644104974 0.9437632216393786 1.5629081282272728 0.9600625354989509 0.05524983857254892 0.14116069552677693 0.35616526512453656 0.03714253489112799 0.08731683891019568 1.3627681184817808e-07 6.865578035163888 0.6191449065878941 NADMSEEMQQDSVECATQALEK(ub)YNIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NADMSEEMQQDSVECATQALEKYNIEK 27 1 P63167;F8VXL2;F8VRV5;F8VXI7 P63167 DYNLL1 Dynein light chain 1, cytoplasmic 1 26521600.0 12725000.0 3526600.0 10270000.0 True False 10581401.31308267 3507601.5058247093 12417409.516885148 1.0 0.3314874279919776 1.1735127654153394 23.335027362888688 -6.695136374396557 1.8479768509299808 0.58292148139178 1.1708116537304412 0.3946307984147369 0.2824459511338407 0.4057311273539059 2.6901554381881474 0.12208751715210225 0.31590339120277416 2.0177326685871226e-07 6.695136374396557 0.5878901723386611 NADMSEEMQQDSVECATQALEK(ub)YNIEK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NADMSEEMQQDSVECATQALEKYNIEK 27 1 P63167;F8VXL2;F8VRV5;F8VXI7 P63167 DYNLL1 Dynein light chain 1, cytoplasmic 1 147769700.0 26959200.0 34148500.0 86662000.0 True False 34899215.845279805 32248105.956056014 70890405.22721092 1.0 0.9240352591021795 2.0312893430469154 25.056691284920515 -6.890460392861962 1.0196287043486914 0.9411611028988219 2.127396443738604 0.9811922636464088 0.06925809095567569 0.11877144275725908 0.21965918621972422 0.05172255531059033 0.12916402456673728 1.2868846100175907e-07 6.890460392861962 1.186235340839782 up NADPILISLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NADPILISLK 10 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;H0YHL7 Q9ULV4 CORO1C Coronin-1C;Coronin 0 8112500.0 2048700.0 2801000.0 3262800.0 False True 2685865.53963902 2383101.7182124867 2925196.7549876277 1.0 0.8872751383275782 1.089107668204706 21.35695565139721 -6.7550907821958015 1.6305881881210738 0.9341275551219776 1.0896809378020758 0.6707881862023775 0.047385128675876124 0.291225941092491 1.5248248208375907 0.022940244729309486 0.05540748251404488 1.7575561870309213e-07 6.7550907821958015 0.1555533826800981 NADPILISLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NADPILISLK 10 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;H0YHL7 Q9ULV4 CORO1C Coronin-1C;Coronin 0 6214700.0 2281700.0 1531500.0 2401500.0 False True 2209268.6824394334 2143035.93666699 1772475.1065442837 1.0 0.9700205111768885 0.8022904233572666 21.075137453500012 -6.937332164021953 0.6839308765929201 1.0019976907866008 0.7604008663050374 0.9977931868456911 0.00408697829806279 0.08900507061167366 0.060311487152580244 0.0039021235578158803 0.014613951569877189 1.1552283440771056e-07 6.937332164021953 -0.2415968244815634 NADPILISLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NADPILISLK 10 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;H0YHL7 Q9ULV4 CORO1C Coronin-1C;Coronin 0 12365600.0 2048700.0 4103800.0 6213100.0 False True 2806159.7540357662 3922480.546548171 4745693.742811124 1.0 1.3978108484048113 1.6911701965598915 21.420165712920102 -6.9744600013273645 0.10725355491376598 0.35593376281954203 2.740521201844684 0.9999996572054786 0.0001657332961865556 0.07488020378286059 0.0031638764582407426 0.02410656584063417 0.0457232788403038 1.060571612888272e-07 6.9744600013273645 2.384587439025142 NAEAVLQSPGLSGKVK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAEAVLQSPGLSGKVK 16 1 Q13045;Q13045-2;Q13045-3 Q13045 FLII Protein flightless-1 homolog 1 3858430.0 998130.0 1303300.0 1557000.0 True False 966444.9094987398 1823714.4866197149 1149174.9910012276 1.0 1.8870340861597688 1.1890744932344497 19.882327970910364 -10.202726683197792 4.72924330214108 0.999908735083267 1.5380542896995029 0.44208081433577195 0.2849408106330214 0.0002742506632363911 4.623447858048597e-05 0.27593927441013194 0.09196425118518614 6.270083389459432e-11 10.202726683197792 0.5381455546162358 NAEAVLQSPGLSGKVK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAEAVLQSPGLSGKVK 16 1 Q13045;Q13045-2;Q13045-3 Q13045 FLII Protein flightless-1 homolog 1 4616630.0 998130.0 2427800.0 1190700.0 True False 829989.3196563622 2414720.959519434 1439669.8648252317 1.0 2.909339797913536 1.7345643259858978 19.66273324634464 -10.13575886034995 4.720295226204603 0.9998899145103284 2.3219520619627523 0.6280235095504648 0.4796000781380832 167512533.32571962 43.91140899095757 200435.47521493662 0.164179863354192 7.315451572093906e-11 10.13575886034995 1.322062147452424 NAELEK(ub)DAQNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAELEKDAQNR 11 1 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 1 1831730.0 782730.0 0.0 1049000.0 True False 1026166.6099681034 0.0 940459.5427185304 1.0 0.0 0.916478409629566 19.9688335574431 -9.473370216991054 12.52426999496064 0.9999849084537618 0.4582392018561343 0.3178335622196492 0.37415074407976434 0.0 0.0 0.36226990015216837 0.1207566333840561 3.3622483026074084e-10 9.473370216991054 -0.5417457065976274 NAELEK(ub)DAQNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAELEKDAQNR 11 1 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 1 3699360.0 914460.0 1100900.0 1684000.0 True False 885430.967850096 1540495.1111176556 1242909.8810828952 1.0 1.739825200442348 1.4037343691522213 19.756020306854364 -10.198851886772678 4.828140936118868 0.999922525891019 1.5717797847988955 0.7941994307574614 0.1372085073204202 0.00011444404498739447 1.8989956035001216e-05 0.1328694661471234 0.04428385531669376 6.326275679891209e-11 10.198851886772678 0.5718572589078764 NAELEK(ub)DAQNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NAELEKDAQNR 11 1 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 1 10062150.0 958850.0 1429100.0 7674200.0 True False 1454645.5513247002 1174065.9393907355 6157391.006278654 1.0 0.8071147904873117 4.232915022268696 20.472236228545768 -6.893564987394874 1.0010364222387882 0.8313489794585576 4.549019438005974 0.9830843342185943 0.20438295819436322 0.11629899201937724 0.20532417497167063 0.15479133468402934 0.39120148973376506 1.2777179988082056e-07 6.893564987394874 3.7176704585474165 up NAELEK(ub)DAQNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAELEKDAQNR 11 1 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 1 3457340.0 782730.0 894210.0 1780400.0 True False 1072126.4334829007 854700.845442965 1359906.1884889866 1.0 0.7972015414883403 1.2684196061384356 20.032043618965993 -6.789725935427614 1.4972454412817806 0.8866182490236326 1.2734074119771663 0.8005128099253138 0.08619915379614296 0.2357466917259513 1.0440154813095646 0.04531497233706 0.10612298748339855 1.6228338749687818e-07 6.789725935427614 0.3867891629535337 NAELEK(ub)DAQNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAELEKDAQNR 11 1 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 1 3414860.0 914460.0 1416600.0 1083800.0 True False 760414.0074468816 1408968.4946269146 1310417.5690749863 1.0 1.8528965548091083 1.7232948844206093 19.53642558228864 -10.357259694260758 5.56031605852839 0.9997897481988197 1.788095719614866 0.980120565274986 0.05290966037739089 0.0001379395483116436 1.594495872840674e-05 0.05124284891670055 0.01707651945792343 4.392788621253033e-11 10.357259694260758 0.7883059714160462 NAELEK(ub)DAQNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAELEKDAQNR 11 1 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 1 14495650.0 958850.0 1296800.0 12240000.0 True False 1241250.2267591967 1224631.940021185 10012445.593005734 1.0 0.9866116546206797 8.066419950751923 20.243362550638217 -6.9064712009186735 0.9194300176324814 0.7555852629394547 8.915532492798054 0.9895202844451323 0.3413341487872386 0.10679832282868497 0.15176756563026914 0.2746672345662671 0.7408898941113183 1.2403058699707246e-07 6.9064712009186735 8.159947229858599 up NAEPLINLDVNNPDFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAEPLINLDVNNPDFK 16 0 Q9Y224;G3V4C6;H0YJB9 Q9Y224 C14orf166 UPF0568 protein C14orf166 0 11184900.0 2238300.0 4606100.0 4340500.0 False True 2934432.9757280303 3918887.8344371733 3891386.697016 1.0 1.3354838453806908 1.3261119709338565 21.484650325764814 -10.080813887630164 4.610129776954657 0.9999809915839615 1.3307979081667867 0.9993983716232143 0.0038260517566332166 7.528083259948484e-07 1.5010092543370482e-07 0.0037047728731241505 0.001234852889613538 8.302064676145147e-11 10.080813887630164 0.3308169165828252 NAEPLINLDVNNPDFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAEPLINLDVNNPDFK 16 0 Q9Y224;G3V4C6;H0YJB9 Q9Y224 C14orf166 UPF0568 protein C14orf166 0 11219400.0 2238300.0 3595000.0 5386100.0 False True 3065859.9977831077 3436161.0129247652 4114014.110211495 1.0 1.1207821020560034 1.3418793138585248 21.547860387287706 -6.961738813566138 0.4101956398750401 0.9891317976726665 1.4817373348303946 0.9998293436965663 0.0018492703000911812 0.07908576019521925 0.01887888262745977 0.0028471791585272135 0.018458784076114315 1.0920969304402963e-07 6.961738813566138 0.49260553715772815 NAFGLHLIDFMSEILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NAFGLHLIDFMSEILK 16 0 E9PHA2;Q15003;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 0 1154990000.0 454440000.0 372100000.0 328450000.0 False True 689418704.0141792 305695847.76943064 263531713.53525105 1.0 0.44341101567088237 0.38225205089566444 29.36080519882882 -13.999999999999998 0.31182819075692686 6.4381022829036505 0.3689715437391276 0.999676007424704 0.005002457998714129 17.400953243081442 0.17774619261720084 61.46070850529677 0.021036278019632326 1.0000000000000041e-14 13.999999999999998 -6.069130739164523 NAFGLHLIDFMSEILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAFGLHLIDFMSEILK 16 0 E9PHA2;Q15003;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 0 830590000.0 454440000.0 219450000.0 156700000.0 False True 588281538.3516176 207237414.58794615 128182207.87777747 1.0 0.3522759105591373 0.21789262372051968 29.13193152092127 -13.999999999999973 0.22106993440700085 4.927080203098112 0.14674352253539785 0.9994989871828223 0.00764279691691912 13.028930803364155 0.14894159476972388 22.34927775819838 0.07384962076199725 1.0000000000000614e-14 13.999999999999973 -4.780336680562714 NAFMMLIHADQDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAFMMLIHADQDR 13 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 6007300.0 1874300.0 2706500.0 1426500.0 False True 2457225.450747017 2302700.74985437 1278899.463954228 1.0 0.937114154158842 0.5204648452446364 21.22859880055012 -6.933775291463163 0.7151316316845917 1.0055354195127055 0.42608196151133204 0.9972294451936402 0.011200274324746348 0.09072472041911293 0.06842261549875085 0.010443582977332232 0.03694837950791907 1.1647285163261793e-07 6.933775291463163 -0.5794534580013735 NAFMMLIHADQDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAFMMLIHADQDR 13 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 7485200.0 1874300.0 3655000.0 1955900.0 False True 2567279.3610529774 3493510.014531299 1493956.7030249448 1.0 1.3607829625126677 0.581922141271059 21.29180886207301 -6.780753704449404 1.5330119682691465 1.2040828725749921 0.5756138002829756 0.7700321518992035 0.1526191860721449 0.24939966370823172 1.1577607149670206 0.07840929326538892 0.18489074608226078 1.6567092441908092e-07 6.780753704449404 -0.6284690722920165 NAFVK(ub)ALQQEQEIEQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAFVKALQQEQEIEQR 16 1 A0A0U1RRM1;Q8WXI9;A0A0U1RR30 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 1 6879200.0 2164100.0 2473200.0 2241900.0 True False 2837156.0571742104 2104208.2004580954 2009929.6938233275 1.0 0.7416610711762798 0.7084311378434378 21.436014077257294 -13.999999999999998 0.2891285935859849 3.2152064654676042 0.6992961037471634 0.9996255108303412 0.002521958648343116 15.91430263609517 0.17050054143212978 20.957967741538976 0.012599827761185872 1.0000000000000041e-14 13.999999999999998 -2.515910361720441 NAFVK(ub)ALQQEQEIEQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAFVKALQQEQEIEQR 16 1 A0A0U1RRM1;Q8WXI9;A0A0U1RR30 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 1 12011800.0 4919700.0 3381100.0 3711000.0 True False 4763526.816407631 4731190.862203575 2738977.772386359 1.0 0.9932117619045037 0.5749894727058413 22.183598679938687 -6.9104267122527805 0.8928263056502729 1.0127748867826707 0.5204454766489399 0.9910815453371127 0.018771468327353068 0.10413646289521523 0.1372425730699063 0.015400949356113388 0.042640200301714934 1.229060574617609e-07 6.9104267122527805 -0.49232941013373077 NAFVK(ub)ALQQEQEIEQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAFVKALQQEQEIEQR 16 1 A0A0U1RRM1;Q8WXI9;A0A0U1RR30 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 1 11434000.0 4919700.0 5020400.0 1493900.0 True False 4090948.5296638757 4993354.108728626 1806267.582986825 1.0 1.2205859038610036 0.4415278192549719 21.964003955372963 -6.831077395881217 1.3231888822752786 1.1177779573448319 0.4201135350838674 0.9079959100932099 0.09944970352622536 0.17948445352168005 0.6142192168182775 0.05900697014348749 0.13578167133373953 1.4754435701578116e-07 6.831077395881217 -0.6976644222609645 down NAFYIGSYQQCINEAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAFYIGSYQQCINEAQR 17 0 M0QXB4;O14579-2;O14579;O14579-3;M0R061 M0QXB4 COPE Coatomer subunit epsilon 0 37633400.0 9425400.0 12310000.0 15898000.0 False True 12356790.675703432 10473395.984004172 14253027.464384368 1.0 0.8475822127987901 1.153457061663221 23.558800757173856 -6.771246656827972 1.5699611220756706 0.9127154108285234 1.15524759200657 0.7352049376117933 0.06425751380445967 0.2644197033442946 1.2864403476164041 0.032260031802542236 0.07669600720274078 1.6933757773299159e-07 6.771246656827972 0.24253218117804654 NAFYIGSYQQCINEAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAFYIGSYQQCINEAQR 17 0 M0QXB4;O14579-2;O14579;O14579-3;M0R061 M0QXB4 COPE Coatomer subunit epsilon 0 16966600.0 7585300.0 1841100.0 7540200.0 False True 7344508.8034832915 2576260.8312096633 5565195.41884872 1.0 0.3507737413273732 0.7577355501581408 22.808234576719048 -10.92647926106071 10.426779202571604 1.0762960955895806 0.554254645742757 0.6153219910539294 0.16614146273924227 0.07932788300158938 0.0005593516982787768 0.04330689888431581 0.0536219265253021 1.1844609274136185e-11 10.92647926106071 -0.5220414498468237 NAFYIGSYQQCINEAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAFYIGSYQQCINEAQR 17 0 M0QXB4;O14579-2;O14579;O14579-3;M0R061 M0QXB4 COPE Coatomer subunit epsilon 0 31056600.0 9425400.0 9445200.0 12186000.0 False True 12910225.091857623 9027879.83290042 9307917.778547969 1.0 0.6992813656358503 0.7209725401626342 23.622010818696747 -10.615831058703256 6.4692738284138676 1.000948230145831 0.7101269528992423 0.9958179246528224 0.008855384918712832 0.00012148152616332409 7.213997719052392e-06 0.008600520553179659 0.0028580631928692628 2.421971014380523e-11 10.615831058703256 -0.2908212772465887 NAFYIGSYQQCINEAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAFYIGSYQQCINEAQR 17 0 M0QXB4;O14579-2;O14579;O14579-3;M0R061 M0QXB4 COPE Coatomer subunit epsilon 0 15741300.0 7585300.0 2130500.0 6025500.0 False True 6307513.0357662765 2119022.5736288587 7285404.191235768 1.0 0.3359521512857922 1.1550359309484473 22.588639852153324 -6.6910595355312115 1.8628455039033125 0.5840951002142494 1.152227171791227 0.37532473810966727 0.2807855713985256 0.41438241147249866 2.788873342514497 0.12055017494142385 0.3134799466232153 2.0367628476555913e-07 6.6910595355312115 0.5681320715769775 NAFYIGSYQQCINEAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAFYIGSYQQCINEAQR 17 0 M0QXB4;O14579-2;O14579;O14579-3;M0R061 M0QXB4 COPE Coatomer subunit epsilon 0 21357000.0 4208100.0 11572000.0 5576900.0 False True 5447468.404052116 10928008.027394466 4561961.423826275 1.0 2.0060709336589513 0.8374461466234199 22.377154492891236 -6.678889789753365 1.9057501021223728 1.6371832393466126 0.8419233177426386 0.31908216866716244 0.42650015787520634 0.4409965573749963 3.0956387280779754 0.1796367417317757 0.4744690225684261 2.0946439430013993e-07 6.678889789753365 -0.795259921603974 NAGAFGFNISFLCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NAGAFGFNISFLCK 14 0 H9KV28;A0A140T8Z0;A0A0G2JH68;O60610-2;O60610-3;O60610;A0A2R8Y5N1 H9KV28 DIAPH1 Protein diaphanous homolog 1 0 74287000.0 22404000.0 21664000.0 30219000.0 False True 33988505.95179491 17797889.938395426 24246201.40454178 1.0 0.5236443744728807 0.713364730974924 25.018543610283242 -10.161187703115454 5.321200055551427 1.0000131220388346 0.6185045527237619 0.8435361203251004 0.07745301120864623 1.205765414810917e-05 1.9009071114027127e-06 0.0749961328733327 0.024997851876987526 6.899415450022515e-11 10.161187703115454 -0.3815085693150727 NAGAFGFNISFLCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAGAFGFNISFLCK 14 0 H9KV28;A0A140T8Z0;A0A0G2JH68;O60610-2;O60610-3;O60610;A0A2R8Y5N1 H9KV28 DIAPH1 Protein diaphanous homolog 1 0 51542000.0 22404000.0 10891000.0 18247000.0 False True 29002419.64886376 10284906.276041573 14926233.2300307 1.0 0.35462235222310184 0.5146547567666642 24.78966993237569 -10.416756085587627 9.064760068775799 1.000002919846655 0.43463855449614164 0.9433133574863438 0.06533295557373067 3.855319981579199e-06 2.479091079995267e-07 0.06325868907898534 0.021086120741297325 3.8303981097896435e-11 10.416756085587627 -0.5653643653505133 NAGAVIGKGGK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAGAVIGKGGK 11 1 P61978;P61978-2;S4R457;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 16927300.0 5574100.0 7539100.0 3814100.0 True False 7307699.0796611905 6414295.667181636 3419453.5194306453 1.0 0.8777449094796367 0.46792478482696126 22.80098579644517 -6.9489326472065835 0.5704439311083762 1.005094930757993 0.32063450905581453 0.9991148176470751 0.006770009213887059 0.08391724702023057 0.037758538300129235 0.007168783625957343 0.03414977208172284 1.1247793974593863e-07 6.9489326472065835 -0.6844604217021786 down NAGAVIGKGGK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 NAGAVIGKGGK 11 1 P61978;P61978-2;S4R457;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 5521830.0 1180200.0 808530.0 3533100.0 True False 1790449.6841773062 664241.5044262765 2834781.236387257 1.0 0.3709914387968344 1.583278916709581 20.77189054544821 -6.765662649995989 1.5908234502891323 0.6372316591316184 1.589050039560084 0.7138089625267832 0.26482621859750655 0.27348643570374614 1.3651693666866491 0.13126511656844736 0.31375473541899446 1.7152891874987093e-07 6.765662649995989 0.9518183804284656 NAGAVIGKGGK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAGAVIGKGGK 11 1 P61978;P61978-2;S4R457;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 15607200.0 5574100.0 6764700.0 3268400.0 True False 7634995.404388531 6465813.186128558 2496471.234810947 1.0 0.8468653671241325 0.3269774377828697 22.86419585796806 -6.948642714748879 0.5735562946848883 1.0063763362291998 0.14203527428815307 0.999090379636088 0.00868719938754359 0.0840354973773529 0.03825439724389211 0.00916665911496469 0.043355388373061014 1.1255305443136175e-07 6.948642714748879 -0.8643410619410467 down NAGAVIGKGGK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAGAVIGKGGK 11 1 P61978;P61978-2;S4R457;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 24329900.0 9084300.0 13053000.0 2192600.0 True False 7553997.952725874 12982680.898182368 2651062.5225630337 1.0 1.7186503066892602 0.35094827125368666 22.84880896210509 -6.763907018547624 1.5975256040202956 1.4153900681140126 0.344919247999049 0.7068188833961595 0.30246227852025986 0.27639333534392585 1.391006366868943 0.14931763750328703 0.35749756474675837 1.7222372625644032e-07 6.763907018547624 -1.0704708201149635 NAGNEQDLGIQYK(ub)ALKPEVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAGNEQDLGIQYKALKPEVDK 21 2 P35221;P35221-2;G3XAM7;E5RIB1;E5RJ41 P35221 CTNNA1 Catenin alpha-1 1 37435400.0 7462400.0 16352000.0 13621000.0 True False 7225510.196711238 22881438.874553517 10053251.478758983 1.0 3.166757537061982 1.3913552406769587 22.784668029917125 -6.596894160506142 2.2026422532375234 2.460109739137705 1.396944836837834 0.011699392279629794 0.9372806252490028 0.6495363426217864 5.951059858295137 0.3538483149190632 1.0431157506314388 2.529914472715953e-07 6.596894160506142 -1.0631649022998708 NAGNEQDLGIQYK(ub)ALKPEVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAGNEQDLGIQYKALKPEVDK 21 2 P35221;P35221-2;G3XAM7;E5RIB1;E5RJ41 P35221 CTNNA1 Catenin alpha-1 1 27698500.0 7462400.0 8306100.0 11930000.0 True False 6205316.240373128 8261353.390668227 14424507.841912327 1.0 1.3313347895016336 2.3245403268995966 22.5650733053514 -6.95146904757048 0.542479960209852 0.9856112448333239 2.71632516691903 0.9993115597912824 0.014766703374896934 0.08290123315119378 0.03356265483853881 0.016186939939003945 0.082284686375289 1.1182295186361302e-07 6.95146904757048 1.7307139220857062 up NAGVEGSLIVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAGVEGSLIVEK 12 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 273987000.0 67349000.0 118720000.0 87918000.0 False True 88295191.20864376 101007438.7669355 78821088.72900634 1.0 1.1439744043166786 0.8926996776387303 26.39583153120918 -6.751329195821077 1.6451617909170173 1.0845234333881089 0.8921562159168352 0.6545904448539872 0.06050298475756328 0.29772479926968587 1.585869064750851 0.029048278292923523 0.07041669566352257 1.7728451523628313e-07 6.751329195821077 -0.1923672174712736 NAGVEGSLIVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAGVEGSLIVEK 12 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 182653000.0 62280000.0 22714000.0 97659000.0 False True 60302955.4903485 31783818.651945215 72079178.19279969 1.0 0.5270690033929136 1.1952843373379265 25.845725375570392 -6.716578223463411 1.7714875805890187 0.7112232168898074 1.1940551217307067 0.49631167743275806 0.19910025312010948 0.3620468279191556 2.2184938351724037 0.08930299252164163 0.22510309247118512 1.9205330115262526e-07 6.716578223463411 0.48283190484089933 NAGVEGSLIVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NAGVEGSLIVEK 12 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 439516000.0 36116000.0 326650000.0 76750000.0 False True 54790612.43327193 268356755.37190118 61580328.859279945 1.0 4.897860116068714 1.1239211632152686 25.70742539396432 -6.638654013539362 2.049319063820117 3.5516057860979724 1.1395816112564758 0.14942664074562906 1.6683484365617107 0.5368040341990714 4.307015739193636 0.6633408060245768 1.8474163085010293 2.297978634239639e-07 6.638654013539362 -2.4120241748414966 NAGVEGSLIVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAGVEGSLIVEK 12 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 198541000.0 67349000.0 53973000.0 77219000.0 False True 92249745.33829011 51588294.3951568 58981462.575225264 1.0 0.5592242472429249 0.6393672129818208 26.45904159273207 -10.809006953860848 7.223615575169423 1.0167172034323446 0.5992957301123728 0.9708722952305178 0.032718228755608196 0.008517939352455558 0.00022521476722237531 0.030633743112690265 0.010559762923989588 1.5523621535593128e-11 10.809006953860848 -0.4174214733199718 NAGVEGSLIVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAGVEGSLIVEK 12 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 104805000.0 62280000.0 20008000.0 22517000.0 False True 51788579.47181056 19900212.93272293 27225200.593155067 1.0 0.3842587137103262 0.5256989257250091 25.62613065100467 -10.079167433803162 7.6208127959091065 1.000000052350489 0.4549788197184673 0.95191828242043 0.05774272475784064 5.137118372670298e-08 6.121950821792816e-09 0.055909157836558976 0.018636384279312967 8.333598369782905e-11 10.079167433803162 -0.5450212326320217 NAGVEGSLIVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAGVEGSLIVEK 12 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 231793000.0 36116000.0 126960000.0 68717000.0 False True 46752873.95279249 119894564.39319065 56211211.09596205 1.0 2.5644319644232163 1.202304935365468 25.47855171605677 -6.612640229655611 2.1439258846159395 2.04333097585201 1.207266810119106 0.058706033561475746 0.6740227085777697 0.6053667647205063 5.276606729254615 0.2592701768090208 0.7480096405168342 2.439831142020865e-07 6.612640229655611 -0.836064165732904 NAHLNALK(ub)MNCYALIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NAHLNALKMNCYALIR 16 1 Q15021 Q15021 NCAPD2 Condensin complex subunit 1 1 84274600.0 5006600.0 24175000.0 55093000.0 True False 7595378.231487972 19860782.36986289 44203844.40188034 1.0 2.6148510007739363 5.819834517078498 22.856690378568345 -6.9601948375707545 0.4326793126847491 0.8762524247612496 7.681884160820571 0.9997773570068057 0.029888203454268097 0.07963159868859686 0.020874702754086847 0.0419041147496583 0.2659514962884942 1.0959863933627907e-07 6.9601948375707545 6.805631736059322 NAHLNALK(ub)MNCYALIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAHLNALKMNCYALIR 16 1 Q15021 Q15021 NCAPD2 Condensin complex subunit 1 1 70398600.0 5006600.0 13697000.0 51695000.0 True False 6481142.39484027 12934749.909369323 42287040.43549277 1.0 1.9957515390599754 6.524627582501209 22.627816700660794 -6.94193785127092 0.6412813547523606 0.9503751526292764 7.818849449546627 0.9984068735136529 0.09596319466983369 0.08689357503346848 0.050666356115534154 0.09484640670650037 0.38658545495197355 1.1430418955103994e-07 6.94193785127092 6.86847429691735 NAHSTAIAGLTFLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAHSTAIAGLTFLHR 15 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 52254000.0 20323000.0 15671000.0 16260000.0 False True 26643649.808211982 13332947.885079576 14577571.176933559 1.0 0.5004174721201355 0.5471311656573615 24.667288389245975 -10.197547704389573 8.281314240182688 1.0000001077590042 0.5237743196664728 0.9928352460454068 0.019070785527825325 3.79505888840757e-08 3.654836447352641e-09 0.01846521281430782 0.006155069562363414 6.345301981884459e-11 10.197547704389573 -0.47622578809253135 NAHSTAIAGLTFLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAHSTAIAGLTFLHR 15 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 29154800.0 6452000.0 6016800.0 16686000.0 False True 6247184.7916462505 8419339.617197486 12315436.030729927 1.0 1.3477013883847082 1.9713577301568148 22.574774774759636 -6.962117161284879 0.4044908497204035 0.9673696226905825 2.374627734807949 0.9998408406195836 0.005069721156156603 0.0789533184184511 0.018399318799537715 0.008023353537544487 0.05216739479459655 1.091145934123924e-07 6.962117161284879 1.4072581121173666 NAHSTAIAGLTFLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAHSTAIAGLTFLHR 15 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 46905000.0 20323000.0 11332000.0 15250000.0 False True 27836962.30842435 10831314.770087194 11648264.083608765 1.0 0.3890983021092533 0.41844594803663726 24.730498450768867 -10.71468867008489 6.7912681452776145 1.0068831382813836 0.40377212507307575 0.9981861770006831 0.011981126278993266 0.0012485724574082318 5.245432042819719e-05 0.011600057020628439 0.003866891878945741 1.9289071810703917e-11 10.71468867008489 -0.603111013208308 NAHSTAIAGLTFLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAHSTAIAGLTFLHR 15 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 20453500.0 6452000.0 4761800.0 9239700.0 False True 5365123.872063611 4736147.238256703 11171678.550454097 1.0 0.8827656828051984 2.082277840522084 22.355180050193912 -6.882887412718228 1.063515551048707 0.9241381138969718 2.1721547048382743 0.9759428502146554 0.0837479830389409 0.12510532053808926 0.25706503433366945 0.06049166662750138 0.14742508624727765 1.3095213616697368e-07 6.882887412718228 1.2480165909413026 up NAIK(ub)TSEESWIEQQMLEDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAIKTSEESWIEQQMLEDK 19 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 29490700.0 9946000.0 9822500.0 9722200.0 True False 9630269.674165152 13744675.473660806 7175664.16025185 1.0 1.4272368208476294 0.7451155993587385 23.199144767406754 -6.737380260976492 1.696424240649372 1.2549735095486634 0.744949950480795 0.5930768934693199 0.17952077751889756 0.32257108042919463 1.8217339036580267 0.08375441748408548 0.20610897133362852 1.830710780706754e-07 6.737380260976492 -0.5100235590678683 NAIK(ub)TSEESWIEQQMLEDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NAIKTSEESWIEQQMLEDK 19 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 58059000.0 13849000.0 24769000.0 19441000.0 True False 21009945.497518633 20348778.42891972 15598477.828707015 1.0 0.9685307575558919 0.7424330458424685 24.324569083692197 -6.932152451217432 0.7289052043561243 1.003178571692013 0.6933649022939913 0.9969446555285819 0.006341301954684976 0.09153551239733221 0.0723166092122555 0.005853041374541632 0.02022125451509662 1.1690889314722247e-07 6.932152451217432 -0.3098136693980217 NAIK(ub)TSEESWIEQQMLEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAIKTSEESWIEQQMLEDK 19 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 14643500.0 3465400.0 5668400.0 5509700.0 True False 4746652.028913726 5417951.345107867 4208422.335833393 1.0 1.1414258538660498 0.8866085632985599 22.17847886081025 -6.756053058068863 1.6272126469022479 1.0825507585312608 0.885851800036012 0.6746666760875426 0.059455479908466724 0.28961379795630304 1.5103986583197488 0.028841303737063687 0.06958616110378812 1.753666242089216e-07 6.756053058068863 -0.19669895849524877 NAIK(ub)TSEESWIEQQMLEDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAIKTSEESWIEQQMLEDK 19 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 25603900.0 9946000.0 9892500.0 5765400.0 True False 8270539.682508468 9839207.13899248 6970918.483802289 1.0 1.1896692980993269 0.842861379233235 22.97955004284103 -6.758186384887282 1.619125574472754 1.1104166030631268 0.8416988082105018 0.6836034350736087 0.07975633397599809 0.2859665482856938 1.4770973515506347 0.038872218957975525 0.09359050207816165 1.7450730643081648e-07 6.758186384887282 -0.26871779485262504 NAIK(ub)TSEESWIEQQMLEDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAIKTSEESWIEQQMLEDK 19 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 40387000.0 13849000.0 26538000.0 0.0 True False 17927803.50460248 25061136.971223123 0.0 1.0 1.3978922161205833 0.0 24.095695405784646 -6.858255771403173 1.3874517098718722 1.210372695874391 1.9810311652751018e-22 0.9062518081484308 0.18005672808747014 0.16700781398226128 0.6462865277315767 0.10458898221145678 0.21870603687127096 1.3859393596925602e-07 6.858255771403173 -1.210372695874391 down NAIQLLASFLANNPFSCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NAIQLLASFLANNPFSCK 18 0 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 0 1291930000.0 599080000.0 347320000.0 345530000.0 False True 908848158.6145918 285338032.3764543 277235844.04882103 1.0 0.3139556697913225 0.30504088215508646 29.759464042394 NAIQLLASFLANNPFSCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAIQLLASFLANNPFSCK 18 0 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 0 859750000.0 599080000.0 100220000.0 160450000.0 False True 775520869.6322674 94642668.89953968 131249746.35602704 1.0 0.12203755257342962 0.1692407664261342 29.53059036448645 -10.412624301316916 5.4387587629144445 1.0005458164317864 0.14563915957721701 0.9977158288931531 0.01927063135979315 0.00012761475561377266 1.378217070450105e-05 0.0186697467874308 0.0062195695272779525 3.867013593106901e-11 10.412624301316916 -0.8549066568545693 NAK(ub)ISSLLEEQFQQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAKISSLLEEQFQQGK 16 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 50942700.0 13210700.0 10608000.0 27124000.0 True False 12791333.559671568 14843829.719989182 20019410.69744209 1.0 1.1604599044144006 1.5650761200191945 23.6086633443523 -6.955276930368288 0.4975521334215875 0.9917220031596602 1.7511929890693279 0.9995529617006437 0.005027044367657545 0.08143345955807262 0.02770950611813746 0.0059229230584270645 0.03337475577314377 1.108467769027209e-07 6.955276930368288 0.7594709859096677 NAK(ub)ISSLLEEQFQQGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NAKISSLLEEQFQQGK 16 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 72544500.0 8895600.0 19385000.0 44263900.0 True False 13495275.555471651 15925595.29430372 35515120.76344343 1.0 1.1800867072956283 2.6316706626300674 23.68595109921962 -6.929956032580471 0.7471554968253924 0.9778901703507319 2.9293376006372616 0.9965295820916148 0.04303037349711058 0.09266054673713565 0.07779262348539913 0.03919256091241051 0.13137493839061484 1.1750165060908731e-07 6.929956032580471 1.9514474302865297 up NAK(ub)ISSLLEEQFQQGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAKISSLLEEQFQQGK 16 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 54331800.0 13210700.0 14069300.0 27051800.0 True False 10985282.383240947 13993505.88836262 32708206.30660893 1.0 1.2738412541593827 2.97745703437795 23.389068619786578 -6.935074461995911 0.7039018886289601 0.9783149160339728 3.3771353628464675 0.9974448272321511 0.04422052016302911 0.0900873353584181 0.06539284599484105 0.041581164722249146 0.15008083219540108 1.1612494946437611e-07 6.935074461995911 2.3988204468124947 up NAK(ub)ISSLLEEQFQQGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAKISSLLEEQFQQGK 16 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 84819600.0 8895600.0 16610000.0 59314000.0 True False 11515529.558491006 15685638.898636555 48519460.61303443 1.0 1.3621291855458535 4.213393779816098 23.457077421312068 -6.930393461924914 0.7435561289855689 0.9572681843502417 4.804650824270714 0.9966150113148331 0.08361015868074284 0.09243398703604123 0.07668321196378178 0.07635197060724534 0.25743421228566293 1.1738336037979432e-07 6.930393461924914 3.8473826399204727 up NAK(ub)TMTTSHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAKTMTTSHLK 11 1 C9JCC6;Q14919;Q14919-2;E9PMW2;E9PQX9 C9JCC6 DRAP1 Dr1-associated corepressor 1 2975430.0 1127500.0 1171600.0 676330.0 True False 1478163.4187255304 996801.8468610311 606349.8594154656 1.0 0.6743515867281249 0.4102048878589211 20.4953743451357 -7.445954024474726 0.1951696117577771 1.2022429879233634 9.741601583920285e-14 0.9999634056156868 0.0014592005988483944 0.12480210761964577 0.016347699998703658 0.028879979911575683 0.06090287777222366 3.581343481145292e-08 7.445954024474726 -1.202242987923266 down NAK(ub)TMTTSHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAKTMTTSHLK 11 1 C9JCC6;Q14919;Q14919-2;E9PMW2;E9PQX9 C9JCC6 DRAP1 Dr1-associated corepressor 1 4203280.0 1429700.0 1785600.0 987980.0 True False 1384314.9560782134 2498599.391780988 729198.3992353211 1.0 1.8049356331882451 0.5267575821770732 20.400740788222112 -6.736484000974546 1.6994970715891715 1.4808791807867139 0.5265602083308533 0.589059277756666 0.3382406828837412 0.3242284041694129 1.8373301725998312 0.15753499100313234 0.38808951941649655 1.8344927469668135e-07 6.736484000974546 -0.9543189724558606 NAK(ub)TMTTSHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAKTMTTSHLK 11 1 C9JCC6;Q14919;Q14919-2;E9PMW2;E9PQX9 C9JCC6 DRAP1 Dr1-associated corepressor 1 2913950.0 1127500.0 1219700.0 566750.0 True False 1544367.2195418193 1165809.6209914726 432895.32258264103 1.0 0.7548785070284925 0.28030595126920127 20.558584406658593 -6.965849829502462 0.4270967701384675 1.0194910919291966 6.031377510263051e-18 0.9997952922049875 0.004274393194264251 0.07865606326408399 0.02024172648345212 0.006145553546905063 0.039026460231918754 1.081807954564844e-07 6.965849829502462 -1.0194910919291966 down NAK(ub)TMTTSHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAKTMTTSHLK 11 1 C9JCC6;Q14919;Q14919-2;E9PMW2;E9PQX9 C9JCC6 DRAP1 Dr1-associated corepressor 1 2903270.0 856080.0 561190.0 1486000.0 True False 1108212.4358596373 529959.2831743432 1215563.2476475919 1.0 0.478210915187263 1.0968684417484296 20.07980303084158 -6.6831412318717325 1.8911778311720822 0.670786892201002 1.0945496660715348 0.3383988653542225 0.22099711541180542 0.4315580242011448 2.9869486151676976 0.09368493949351406 0.24605708674114293 2.0742388685970046e-07 6.6831412318717325 0.42376277387053285 NALESYAFNMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 NALESYAFNMK 11 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 45050300.0 6193100.0 20835800.0 18021400.0 False True 8119214.074065705 17727179.857312296 16156718.401475409 1.0 2.183361553913973 1.9899362492587802 22.952908653098717 -10.308173882781235 6.4618620000817435 0.9999632238746741 2.0866489015863676 0.9767881509893699 0.07896554995793492 4.1842391577790575e-05 4.479724476093814e-06 0.07646063043126441 0.025486021659265924 4.918425723740648e-11 10.308173882781235 1.0866856777116936 NALESYAFNMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NALESYAFNMK 11 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 25814200.0 6630900.0 3008300.0 16175000.0 False True 6420405.709071149 4209529.878077257 11938282.260401322 1.0 0.6556485787385322 1.8594280176927407 22.614233034268548 -6.8302429866120065 1.3268752073596202 0.8160353064431004 1.891971107423234 0.9063530102264894 0.15491076967351505 0.1805095269532504 0.6214662707795404 0.09166558852735966 0.2109412941158948 1.4782810624086396e-07 6.8302429866120065 1.0759358009801336 NALESYAFNMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NALESYAFNMK 11 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 33500400.0 6193100.0 11309600.0 15997700.0 False True 8482856.432234539 10809904.476154098 12219372.742973663 1.0 1.2743236388012962 1.4404785511329063 23.01611871462161 -10.606413466410126 0.07733384986978142 3.8884278288460136e-17 2.0730131584954608 0.9999617752467204 0.001122890686655499 2.639376905039413 0.04366541184984339 0.8583591799575498 0.37566169071343436 2.475064571183105e-11 10.606413466410126 2.0730131584954608 NALESYAFNMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NALESYAFNMK 11 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 12130100.0 6630900.0 2784600.0 2714600.0 False True 5513887.148677392 2769598.8071001726 3282210.3091077283 1.0 0.5022951562881574 0.5952625109302477 22.394638309702824 -10.09529870339782 5.386626682731247 1.0000060408929026 0.5487788336089843 0.9691445523495317 0.03795376360253326 2.7534882683777972e-06 4.6245693122371766e-07 0.036749065670253274 0.01224952452973767 8.029736549737222e-11 10.09529870339782 -0.4512272072839183 NALESYAFNMK(ub)SAVEDEGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NALESYAFNMKSAVEDEGLK 20 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 24346500.0 6061300.0 7909200.0 10376000.0 True False 5868887.34928787 11067384.805933138 7658214.326672294 1.0 1.8857722336885632 1.3048835104326104 22.484655585808206 -10.129312364163997 4.518387449972072 0.999945388685562 1.5953278720737207 0.5834101383676147 0.23714682842847576 165553769.1179973 16.77021083757327 119338.27228440998 0.08118166707408171 7.424849171874676e-11 10.129312364163997 0.5953824833881587 NALESYAFNMK(ub)SAVEDEGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NALESYAFNMKSAVEDEGLK 20 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 88091000.0 15594000.0 41397000.0 31100000.0 True False 23657238.074106835 34009381.913762696 24953071.368385755 1.0 1.4375888600024878 1.0547753414925145 24.49577831652924 -10.382516194686152 6.30059087278493 0.999968323029215 1.2461821007475011 0.35542639061963777 0.15628296449815304 6.954941997966432e-05 6.816303723726512e-06 0.15133976843755068 0.050440109899772635 4.1446112864228644e-11 10.382516194686152 0.24621377771828612 NALESYAFNMK(ub)SAVEDEGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NALESYAFNMKSAVEDEGLK 20 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 20691900.0 6061300.0 5886600.0 8744000.0 True False 5040239.511118893 5854887.717401379 10572329.972311936 1.0 1.1616288679308497 2.097584836789822 22.265060861242482 -6.936591190772607 0.6905523691975554 0.9886218768984906 2.3265300920193 0.9976824005425697 0.02329231544187421 0.08935677175334501 0.061953903568668436 0.022125518323512106 0.08183858413979463 1.1572010238582114e-07 6.936591190772607 1.3379082151208097 up NALESYAFNMK(ub)SAVEDEGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NALESYAFNMKSAVEDEGLK 20 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 64930000.0 15594000.0 33736000.0 15600000.0 True False 20186740.40369493 31858561.94367264 12760960.069517113 1.0 1.5781924821226376 0.6321456468118736 24.26690463862169 -6.7412900646190375 1.681939294677623 1.3434957023198735 0.6314257178929794 0.6108012344529865 0.2429246630942175 0.31545350699654146 1.7526996046312413 0.11423667141210249 0.27993421256103374 1.8143034874937687e-07 6.7412900646190375 -0.7120699844268941 NALGAIHHTISVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NALGAIHHTISVR 13 0 C9JH43;A0A087X2B3;C9JYY6;F8W775;Q92823-3;Q92823-4;Q92823-6;Q92823-2;Q92823;Q92823-5 C9JH43 NRCAM Neuronal cell adhesion molecule 0 10555000.0 2474100.0 2458500.0 5622400.0 False True 3243569.0592184844 2091701.383157941 5040647.981869074 1.0 0.6448764755642113 1.5540436752974771 21.629150725060864 -6.800770317254517 1.452806470638259 0.8042547776521397 1.5668284502498708 0.8343983819793479 0.15224325678512027 0.21965782519841076 0.9152254470909152 0.08243762702530466 0.19162675124978423 1.58208452571189e-07 6.800770317254517 0.7625736725977311 NALGAIHHTISVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NALGAIHHTISVR 13 0 C9JH43;A0A087X2B3;C9JYY6;F8W775;Q92823-3;Q92823-4;Q92823-6;Q92823-2;Q92823;Q92823-5 C9JH43 NRCAM Neuronal cell adhesion molecule 0 5370800.0 2414200.0 0.0 2956600.0 False True 2337562.5424662675 0.0 2182177.7639012416 1.0 0.0 0.9335270069817744 21.156573534751764 -10.039527187406167 13.072852085109739 0.9999999999707918 0.4667635034908872 0.30315312660099547 0.3811108047021561 0.0 0.0 0.3690089499177895 0.12300298330592979 9.130042782346669e-11 10.039527187406167 -0.5332364964799046 NALGAIHHTISVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NALGAIHHTISVR 13 0 C9JH43;A0A087X2B3;C9JYY6;F8W775;Q92823-3;Q92823-4;Q92823-6;Q92823-2;Q92823;Q92823-5 C9JH43 NRCAM Neuronal cell adhesion molecule 0 6737600.0 2474100.0 1933800.0 2329700.0 False True 3388841.630038512 1848358.3217785587 1779472.8416775968 1.0 0.5454248157821271 0.5250976693346907 21.692360786583755 NALGAIHHTISVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NALGAIHHTISVR 13 0 C9JH43;A0A087X2B3;C9JYY6;F8W775;Q92823-3;Q92823-4;Q92823-6;Q92823-2;Q92823;Q92823-5 C9JH43 NRCAM Neuronal cell adhesion molecule 0 5232500.0 2414200.0 1143900.0 1674400.0 False True 2007514.2671940408 1137737.5836536263 2024509.298449124 1.0 0.5667394759011471 1.0084657088284794 20.93697881018604 -10.939850959826092 11.031072889418999 1.0460936145040935 0.7876025923648152 0.23563158702309206 0.18033397944562554 0.10512642058689697 0.0005732212397822582 0.08979188470791803 0.058202541595684894 1.1485477098133784e-11 10.939850959826092 -0.2584910221392783 NALIHK(ub)SSVNCPFSSQDMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NALIHKSSVNCPFSSQDMK 19 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 10438700.0 2857100.0 4540100.0 3041500.0 True False 3745685.768195755 3862734.777171186 2726794.756128131 1.0 1.0312490198642084 0.7279827846962161 21.836798443896885 -6.881479929648245 1.0714823278558654 1.0197754667899672 0.7058685947987187 0.9748609054219316 0.021594050354024143 0.12632852129977418 0.26441745271927014 0.015503085920101843 0.03763635696489973 1.3137722078223408e-07 6.881479929648245 -0.31390687199124856 NALIHK(ub)SSVNCPFSSQDMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NALIHKSSVNCPFSSQDMK 19 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 7551400.0 2041500.0 1903500.0 3606400.0 True False 1976693.6999606013 2663577.4766213647 2661775.6503190966 1.0 1.3474912560678745 1.3465797206578591 20.91465790382914 -10.058514632451512 4.51429351420348 0.9999804936662497 1.3470354883810922 0.9999948243724149 0.0003721328450466862 57553.34052031583 64118.68672046022 8.959220697657765 0.00012739095846223537 8.73947546647651e-11 10.058514632451512 0.34705499471484247 NALIHK(ub)SSVNCPFSSQDMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NALIHKSSVNCPFSSQDMK 19 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 32911600.0 4273200.0 4964400.0 23674000.0 True False 6482756.81276603 4078464.032965765 18994823.523317166 1.0 0.6291249464941113 2.9300533819056755 22.628176023532742 -6.865603702004638 1.1571710674849618 0.7949237391880549 3.0539707609652966 0.96009108744913 0.20150626121136456 0.14113583836587076 0.3559976086427813 0.1354798356235189 0.3185079958001666 1.362687581150192e-07 6.865603702004638 2.2590470217772416 up NALIHK(ub)SSVNCPFSSQDMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NALIHKSSVNCPFSSQDMK 19 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 12269800.0 2857100.0 3409200.0 6003500.0 True False 3913447.0802243305 3258570.271283205 4585596.945963623 1.0 0.8326598531891771 1.1717539171887212 21.900008505419777 -6.772571092956505 1.5651134933337723 0.9043312613648641 1.1738261073665073 0.7401111513663872 0.0705749609776018 0.2622979009414611 1.2684577888640676 0.035539188555360424 0.0843827193866124 1.6882194794195577e-07 6.772571092956505 0.2694948460016432 NALIHK(ub)SSVNCPFSSQDMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NALIHKSSVNCPFSSQDMK 19 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 9093000.0 2041500.0 2913500.0 4138000.0 True False 1697597.7037845384 2897804.39721553 5003236.668049731 1.0 1.7070030141742718 2.9472451905983195 20.695063179263418 -6.962525709034624 0.3982423482397872 0.9304864577771208 3.7689193624753905 0.9998527080355226 0.009767775870269347 0.07881092926876491 0.017885917537218052 0.01596281282953168 0.10398090371415404 1.0901199583823536e-07 6.962525709034624 2.8384329046982697 NALIHK(ub)SSVNCPFSSQDMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NALIHKSSVNCPFSSQDMK 19 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 33915500.0 4273200.0 4981300.0 24661000.0 True False 5531741.637364968 4704086.276085387 20172951.043228284 1.0 0.8503806910125629 3.6467630568584584 22.39930234562519 -6.894265743180061 0.9968259753253778 0.8647485100422075 3.9083628315255297 0.9834904721986688 0.16503371049849389 0.11574954581175806 0.20218537437537762 0.12538927609872322 0.3177942593384188 1.2756579995577385e-07 6.894265743180061 3.043614321483322 up NALYIK(ub)SSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NALYIKSSK 9 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 18825700.0 3986000.0 5256200.0 9583500.0 True False 5159955.575806592 4963687.849428864 7839401.335013915 1.0 0.961963291448096 1.5192769045862335 22.29892721426739 -6.890551443737796 1.0190919805091097 0.9704495999883508 1.5677362720231747 0.9812496832750793 0.034812101837690575 0.11869780548141148 0.21923228013739435 0.02600858842715925 0.06497131948033835 1.2866148398641843e-07 6.890551443737796 0.5972866720348239 NALYIKSSK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NALYIKSSK 9 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 13129800.0 2963000.0 6499800.0 3667000.0 True False 2463865.783156304 6464784.287290709 4433752.745707676 1.0 2.623837845180462 1.7995106616675658 21.23249223799955 -10.259474239937996 5.597590294008801 0.9999132586708179 2.2116742534240457 0.7423203536022899 0.3365301634521423 0.0003643201911745361 4.819713675750103e-05 0.32586684255534304 0.10861464321220113 5.502065548987256e-11 10.259474239937996 1.2117609947532277 NAMGSLASQATK(ub)DGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAMGSLASQATKDGK 15 1 P55036;H0Y3Y9;H0Y561;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 12663400.0 3646900.0 5940400.0 3076100.0 True False 4781121.216629832 5054115.475497843 2757814.680034766 1.0 1.0570983764056168 0.5768133780926651 22.18891755238143 -6.8772321282369475 1.095162273720776 1.0342421377407311 0.5445377367889683 0.9713814540544848 0.03624002553229859 0.13010806548356732 0.2873663950433565 0.025551735825016304 0.06137671982656771 1.3266851615796002e-07 6.8772321282369475 -0.4897044009517628 NAMGSLASQATK(ub)DGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAMGSLASQATKDGK 15 1 P55036;H0Y3Y9;H0Y561;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 23125600.0 6800500.0 8291300.0 8033800.0 True False 6584621.849905507 11602059.328558289 5929506.77116614 1.0 1.761993261423932 0.9005083217119343 22.65066915924694 -6.6732871696545555 1.9261859877891316 1.4850059799984021 0.9039701218103775 0.2935329172626441 0.32343652058217337 0.45358482595308874 3.247643624064766 0.13504673999661532 0.3592105447360888 2.1218409676861288e-07 6.6732871696545555 -0.5810358581880246 NAMGSLASQATK(ub)DGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NAMGSLASQATKDGK 15 1 P55036;H0Y3Y9;H0Y561;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 20082800.0 4340600.0 9431500.0 6310700.0 True False 6585007.540366056 7748375.1363541605 5063387.378921925 1.0 1.17666913649782 0.7689265878411514 22.65075366180938 -6.788942586400201 1.5004601497470444 1.098877740624074 0.764710250319799 0.7978940689518855 0.07505588571006731 0.23694028385010724 1.0538389681015263 0.03937457463092354 0.0922607900583237 1.625763667012046e-07 6.788942586400201 -0.33416749030427495 NAMGSLASQATK(ub)DGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAMGSLASQATKDGK 15 1 P55036;H0Y3Y9;H0Y561;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 8541500.0 3646900.0 4894600.0 0.0 True False 4995257.483766794 4678340.387722277 0.0 1.0 0.9365564043346294 0.0 22.25212761390432 -7.078411589543755 1.0153928383171793 1.0050543135701377 3.2342814854793915e-21 0.9889923913911752 0.047966545758776125 0.08435938624710722 0.1662158476996346 0.039077008892384794 0.06938501211154613 8.348114757219172e-08 7.078411589543755 -1.0050543135701377 down NAMGSLASQATK(ub)DGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAMGSLASQATKDGK 15 1 P55036;H0Y3Y9;H0Y561;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 19005500.0 6800500.0 12205000.0 0.0 True False 5654917.063231337 12139249.242497168 0.0 1.0 2.146671490803536 0.0 22.431074434681218 -6.765757636126986 1.6176951966863908 1.664559266086826 1.291169961262056e-09 0.6972686886347101 0.48256550678305826 0.27719644938720167 1.4353292670991962 0.236293240067 0.5586334817524078 1.714914071363954e-07 6.765757636126986 -1.664559264795656 NAMGSLASQATK(ub)DGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAMGSLASQATKDGK 15 1 P55036;H0Y3Y9;H0Y561;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 11380600.0 4340600.0 4843500.0 2196500.0 True False 5618992.266017593 4573954.96722132 1796759.5379932239 1.0 0.8140169536953404 0.31976544065732626 22.421879983901828 -6.954139638935468 0.5113850533477746 1.008993679010856 0.10305398956128332 0.9994873665570871 0.006499275434451013 0.08186488341452967 0.02940367791806572 0.00746811958692329 0.040795626530886454 1.1113743290490568e-07 6.954139638935468 -0.9059396894495727 down NAMGSLASQATK(ub)DGKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAMGSLASQATKDGKK 16 2 P55036;H0Y3Y9;H0Y561;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 11511900.0 3933500.0 4093300.0 3485100.0 True False 5156856.592068185 3482595.595558433 3124495.2834398015 1.0 0.6753330315438768 0.6058914432962166 22.298060495259055 -13.999999999999993 0.21676176161907879 2.9318278601235788 0.5675744870333336 0.9994948618351709 0.003860632019573015 12.913560035374383 0.14751739896352914 10.660395147352382 0.03926843791775025 1.0000000000000164e-14 13.999999999999993 -2.364253373090245 NAMGSLASQATK(ub)DGKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAMGSLASQATKDGKK 16 2 P55036;H0Y3Y9;H0Y561;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 27287900.0 8317500.0 9341500.0 9628900.0 True False 8053465.515269309 13071609.665278953 7106802.229191869 1.0 1.6231036987114777 0.8824526802427385 22.94117829737422 -6.683631031874318 1.8891947640061288 1.392953196555398 0.8851986099922629 0.34077182502296777 0.2638788353335258 0.43047939579329714 2.9735811665174983 0.11195758252688384 0.29389163892798115 2.0719008478378206e-07 6.683631031874318 -0.5077545865631352 NAMGSLASQATK(ub)DGKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NAMGSLASQATKDGKK 16 2 P55036;H0Y3Y9;H0Y561;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 35198000.0 8973200.0 9577800.0 16647000.0 True False 13613000.428791553 7868566.75830705 13356713.153360698 1.0 0.5780185492145433 0.9811733440565531 23.698481749176903 -10.664169401951652 9.63640544979666 1.0001279439545099 0.7795959477815321 0.2849509295979561 0.16458725578655992 0.0004526698675146591 1.5775649986727226e-05 0.15945215033530727 0.053120308388277214 2.166858729820665e-11 10.664169401951652 -0.2205319961729778 NAMGSLASQATK(ub)DGKK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NAMGSLASQATKDGKK 16 2 P55036;H0Y3Y9;H0Y561;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 14050000.0 5518100.0 6868900.0 1663000.0 True False 7558290.691045424 6565409.285585249 1270233.6505600915 1.0 0.8686367796575386 0.1680583219781402 22.84962857488486 -6.955488360816622 0.6850456502003794 1.0072981162022012 5.4454148358208455e-18 0.9979531624733817 0.01652136880759127 0.0849513362722016 0.058584457083124875 0.015933535353208034 0.05800297480604003 1.1079282576865343e-07 6.955488360816622 -1.0072981162022012 down NAMGSLASQATK(ub)DGKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAMGSLASQATKDGKK 16 2 P55036;H0Y3Y9;H0Y561;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 25178100.0 8317500.0 14335000.0 2525600.0 True False 6916369.77772613 14257774.5097253 3053691.2829449987 1.0 2.061453474573012 0.4415164864058136 22.721583572808495 -6.729930374124403 1.723471409458667 1.6388302559081906 0.4424928673373531 0.5589350153969181 0.4462126288643385 0.3363760178414448 1.9574062208699972 0.20517273723136806 0.5091648049185918 1.8623856894788802e-07 6.729930374124403 -1.1963373885708375 NAMGSLASQATK(ub)DGKK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NAMGSLASQATKDGKK 16 2 P55036;H0Y3Y9;H0Y561;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 44275700.0 14502000.0 20263600.0 9510100.0 True False 18773124.877156846 19135912.846864004 7779359.3818663135 1.0 1.0193248578529726 0.41438809110209696 24.16216547791507 -6.899519135369208 0.9642888376053054 1.0254839791320323 0.35150315540871147 0.9863259609831306 0.03282697578769527 0.11176058468648853 0.1794167588187235 0.025554811371715433 0.06633131632932925 1.2603201059388956e-07 6.899519135369208 -0.6739808237233208 down NAQAQQEFK(ub)NANAVMEYEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAQAQQEFKNANAVMEYEK 19 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EK03;K7EIH8;K7EPP7;K7ESP1;K7EJV7;K7EN19;K7EJL5 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 11504400.0 2535500.0 4266800.0 4702100.0 True False 2455011.9403625308 5970555.49106805 3470478.9500236833 1.0 2.431986334936677 1.413630171391834 21.227298610670626 -10.222572801312415 5.849387907072522 0.9999738416710556 1.9228082531642616 0.5226432535453267 0.41574216285055776 0.00014183616966306292 1.8850075712498422e-05 0.40255197655249764 0.13418020608636627 5.990005190090432e-11 10.222572801312415 0.922834411493206 NAQAQQEFK(ub)NANAVMEYEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAQAQQEFKNANAVMEYEK 19 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44;A0A6I8PLE7;A0A6I8PU89;A0A6I8PUC2;K7EK03;K7EIH8;K7EPP7;K7ESP1;K7EJV7;K7EN19;K7EJL5 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 8050200.0 2535500.0 3096000.0 2418700.0 True False 2108380.5916951746 3079321.2334921146 2924438.98719475 1.0 1.460514883138953 1.3870545947510597 21.007703886104903 -10.66202165449864 6.486730148822729 0.9972787340384703 1.4237847389450062 0.9779607239571634 0.029990037151339768 0.0011858715112755547 6.178746506169133e-05 0.029175924428346107 0.00967924286994005 2.1776011915637946e-11 10.66202165449864 0.4265060049065359 NAQFIIISLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAQFIIISLR 10 0 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 8431200.0 3065200.0 2711700.0 2654300.0 False True 2967896.90380565 3794495.9513286906 1959059.202706846 1.0 1.2785133966288103 0.6600833068678362 21.50100954708086 -6.784271916263533 1.5192168651471079 1.1568254355039937 0.654510564931937 0.7822268123531706 0.11801292873280698 0.2439876554771926 1.112490573621144 0.061166640048599806 0.14382155597264681 1.6433424873257576e-07 6.784271916263533 -0.5023148705720567 NAQFIIISLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NAQFIIISLR 10 0 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 33009800.0 8514800.0 14484000.0 10011000.0 False True 12917574.115262605 11899217.03599147 8032321.462022833 1.0 0.9211649904088487 0.6218134605113153 23.622831825536924 -6.946071915838715 0.6004314325845473 1.003368595805922 0.5242748205929693 0.9988557717229423 0.005510597625470655 0.08510268243670455 0.04279484918479519 0.005653350391392995 0.025160229248122126 1.1322128619364761e-07 6.946071915838715 -0.4790937752129527 NAQFIIISLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAQFIIISLR 10 0 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 10444800.0 1042400.0 3272400.0 6130000.0 False True 1427803.4498007917 3127814.5476203077 4682220.251312903 1.0 2.1906478430604035 3.2793170880531 20.44536596219662 -6.972194739401656 0.19889459986732985 0.3426829698047259 5.157304277110852 0.9999948219787982 0.0021181380545825844 0.07559678193809828 0.006413316857507714 0.035669201349845504 0.1159008725893279 1.0661179624291411e-07 6.972194739401656 4.814621307306126 NAQFIIISLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAQFIIISLR 10 0 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 4076700.0 3065200.0 1011500.0 0.0 False True 2548849.611383966 1006050.8487329691 0.0 1.0 0.3947078102370688 0.0 21.281414822515135 -8.30242712274571 0.5343984859919697 1.0339854416259076 1.0559494585498885e-16 0.9920303596902674 0.03671386375820524 0.15174282636183495 0.17701142653885357 0.06041532159480592 0.07102138196993892 4.9839408251076765e-09 8.30242712274571 -1.0339854416259076 NAQFIIISLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAQFIIISLR 10 0 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 26980800.0 8514800.0 10815000.0 7651000.0 False True 11022576.451800805 10213135.742850935 6258596.505889449 1.0 0.9265651989360775 0.5677979674948824 23.393958147629373 -6.940324134661252 0.6565494159309672 1.0040057788983496 0.4701230484582509 0.9982059327345371 0.007998091460479332 0.08761932432034285 0.05394037068590638 0.007804734814850634 0.030834601427407717 1.1472970194533484e-07 6.940324134661252 -0.5338827304400987 NAQLELK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAQLELKK 8 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 2924900.0 920090.0 1221000.0 783810.0 True False 1260272.1374973257 1167052.1826929452 598690.2210736646 1.0 0.9260318846773059 0.475048367142795 20.265303865767944 -6.9354960329832975 0.7002067700969399 1.0056647762276056 0.36801597508300443 0.99751250260147 0.011571142866539638 0.08988265956659916 0.06442381981843677 0.010910874885307694 0.039645953688972335 1.1601228131179649e-07 6.9354960329832975 -0.6376488011446012 down NAQLELK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAQLELKK 8 1 Q99615;A0A6I8PU73;A0A6I8PUD4;A0A6I8PS32;A0A6I8PIK4;Q99615-2;A0A6I8PRZ0;A0A6I8PR89;K7ER44 Q99615 DNAJC7 DnaJ homolog subfamily C member 7 1 5348600.0 1282900.0 3062900.0 1002800.0 True False 1066788.1921063843 3046399.5497619505 1212480.843576672 1.0 2.855674230651919 1.1365713011714313 20.024842330743123 -6.628050136386173 2.0872439761702353 2.224275191946135 1.1433991529436693 0.11056202968695694 0.796378075419851 0.5641464321796008 4.680932737867716 0.3123162498207406 0.8824675677974896 2.3547774249382548e-07 6.628050136386173 -1.0808760390024656 NAQLNIELEAAHH ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAQLNIELEAAHH 13 0 P43490 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 18557200.0 6427800.0 8261700.0 3867700.0 False True 8426908.046903742 7029086.563854373 3467507.5055981474 1.0 0.8341240375154011 0.4114804013878135 23.006571952133974 -6.955053325524052 0.500303561167669 1.0084420122366258 0.218924102190645 0.9995404831016504 0.005311222643496266 0.08151784673653004 0.028039238751497445 0.006225143003807804 0.03486462346752197 1.1090386318669092e-07 6.955053325524052 -0.7895179100459808 down NAQLNIELEAAHH ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAQLNIELEAAHH 13 0 P43490 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 20093300.0 5635900.0 4754100.0 9703300.0 False True 5456991.439435684 6652436.922303983 7161714.637239705 1.0 1.2190667689579373 1.3123924999193894 22.37967434983272 -13.804211094518573 0.11833019808951922 4.897247510097234e-16 1.4661729633094127 0.9997053853029675 0.0022473567583672425 11.222612766086469 0.10393825745469203 2.676348373479662 0.13490530972458517 1.5695996944086293e-14 13.804211094518573 1.4661729633094123 NAQLNIELEAAHH ddPTM_RPMI8226_Bortezomib_8h_R1 1 NAQLNIELEAAHH 13 0 P43490 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 129521000.0 17559000.0 74344000.0 37618000.0 False True 26638286.73484941 61076732.34767673 30182785.811444897 1.0 2.292817588293822 1.1330603244824455 24.66699796138722 -6.620194449377645 2.116492676732513 1.8577409286661113 1.1375398341361715 0.08322533648322306 0.5559380140996905 0.5849499355039844 4.979634350639807 0.21583484047885115 0.6162513109986907 2.3977591150004255e-07 6.620194449377645 -0.7202010945299397 NAQLNIELEAAHH ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAQLNIELEAAHH 13 0 P43490 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 70711000.0 17559000.0 41471000.0 11681000.0 False True 22730471.639635697 39163102.394061126 9555177.857181355 1.0 1.7229339986844547 0.42036865792611844 24.43812428347967 -6.756036765740049 1.6272348408558928 1.4219729381659214 0.4164923077243635 0.6746710304768644 0.3039202071557714 0.28961210902991924 1.5104203210109772 0.14742700971882872 0.35571234679411734 1.753732031188922e-07 6.756036765740049 -1.005480630441558 NASAVMK(ub)NQVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NASAVMKNQVAR 12 1 Q13761;Q13761-2;I3L354;A0A2R8Y7Z3;A0A0D9SEN7;I3L0L0;Q13950-3;Q13950-2;Q13950 Q13761 RUNX3;RUNX2 Runt-related transcription factor 3;Runt-related transcription factor 2 1 2340430.0 381960.0 636370.0 1322100.0 True False 369834.8888743334 890475.8596257102 975802.3478501769 1.0 2.407765969122199 2.63848105520879 18.496521804186344 -10.419878732171671 0.38081341279987563 8.295794363294315e-21 2.667504422787644 0.999176906293715 0.02077583460758554 1.8674628334829235 0.17920610434112796 1.9151938621086293 0.062051866475250586 3.802955712361262e-11 10.419878732171671 2.667504422787644 NASAVMK(ub)NQVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NASAVMKNQVAR 12 1 Q13761;Q13761-2;I3L354;A0A2R8Y7Z3;A0A0D9SEN7;I3L0L0;Q13950-3;Q13950-2;Q13950 Q13761 RUNX3;RUNX2 Runt-related transcription factor 3;Runt-related transcription factor 2 1 1928030.0 381960.0 736680.0 809390.0 True False 317616.6636970574 732711.3586204697 978629.7068034736 1.0 2.30690465069342 3.0811661309335148 18.27692707962062 -8.701406915863322 0.2021517260934119 5.169232593602866e-23 3.934117587550842 0.9996308382524444 0.016501737288707956 0.2667897578362156 0.058609774626838175 0.5613368827422762 0.391616541239235 1.9888090344029107e-09 8.701406915863322 3.934117587550842 NASNTEK(ub)LTDQVMQNPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NASNTEKLTDQVMQNPR 17 1 Q99733;Q99733-2;C9J6D1;C9JZI7;E9PKT8;E9PNW0;E9PJJ2;E9PS34;E9PNJ7;E9PKI2;E9PP22;C9J1B1 Q99733 NAP1L4 Nucleosome assembly protein 1-like 4 1 4320200.0 1976200.0 2344000.0 0.0 True False 2558229.8567257854 2213554.3394583995 0.0 1.0 0.8652679639551516 0.0 21.286714465389014 -7.158323796625888 0.9298512501389693 0.9934537538181628 1.1951413852448891e-21 0.9896511959501522 0.045073637082471675 0.08859535091802312 0.14506287524767167 0.03775467039520344 0.06629531277315448 6.945063219308379e-08 7.158323796625888 -0.9934537538181628 down NATGPRPALFVPEVSFELLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NATGPRPALFVPEVSFELLVK 21 1 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 20077200.0 5386900.0 6157100.0 8533200.0 False True 8172321.135142114 5058317.399358131 6846609.279765575 1.0 0.6189572479728758 0.8377802544156281 22.96231446587868 -10.188638683967584 5.419118408269256 1.0000108922270778 0.7283687511942084 0.672617262952517 0.08933411829456944 1.1756589118034258e-05 1.7603148161874798e-06 0.08650085439242113 0.028832462700227088 6.476812371330473e-11 10.188638683967584 -0.27164214103286943 NATGPRPALFVPEVSFELLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NATGPRPALFVPEVSFELLVK 21 1 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 15110000.0 5386900.0 3214000.0 6509100.0 False True 6973448.241673992 3035138.0746669346 5324510.589006016 1.0 0.4352420738607709 0.7635405619254808 22.73344078797113 -10.273261159828525 5.8302691860893034 1.0000232079773013 0.5993913178931387 0.6650332628238447 0.13402729651429784 4.0433925319523434e-05 5.040026184104808e-06 0.1297788757895467 0.04325712394475526 5.3301427483771336e-11 10.273261159828525 -0.40063189008416256 NATMPVTMLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NATMPVTMLIR 11 0 Q9UKX7;Q9UKX7-2 Q9UKX7 NUP50 Nuclear pore complex protein Nup50 0 4884500.0 1289600.0 1441200.0 2153700.0 False True 1690678.0885041635 1226178.5777535995 1930855.7837491897 1.0 0.72525845463489 1.1420599798850677 20.689170560633563 -6.728919356629934 1.7271397560451438 0.8344644429951169 1.141765216630672 0.5542767992895998 0.11550480675355211 0.33826038228551375 1.9762882217549704 0.05300745207904611 0.13169716419026659 1.866726287739081e-07 6.728919356629934 0.3073007736355551 NATVYGK(ub)GVYFAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NATVYGKGVYFAR 13 1 E9PK67;E9PNI7;Q53GL7 E9PK67 PARP10 Poly [ADP-ribose] polymerase 10 1 24883900.0 2583200.0 10144400.0 12156300.0 True False 3386600.2157443846 8630895.062561495 10898482.687463561 1.0 2.548542642392881 3.2181190554457113 21.691406257719578 -9.389090369348102 0.25672998536773123 6.638903507843798e-14 3.615753453821283 0.9990428141717401 0.028739941380703057 0.7944824086934871 0.0995281716032327 0.9496399793594074 0.2815838096849563 4.082344308025701e-10 9.389090369348102 3.615753453821217 NATVYGK(ub)GVYFAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NATVYGKGVYFAR 13 1 E9PK67;E9PNI7;Q53GL7 E9PK67 PARP10 Poly [ADP-ribose] polymerase 10 1 48546700.0 2973600.0 23694100.0 21879000.0 True False 2879204.695666349 33155277.69309921 16148233.544069277 1.0 11.515429154100456 5.608574329006506 21.457238929578388 -9.693538036350809 8.690126286257325 1.0001440712146388 8.56200174155322 0.6860521852783237 2.4114633857974046 0.0 0.0 2.3348892434971655 0.7782964608824542 2.0251722305562342e-10 9.693538036350809 7.561857670338581 NATVYGK(ub)GVYFAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NATVYGKGVYFAR 13 1 E9PK67;E9PNI7;Q53GL7 E9PK67 PARP10 Poly [ADP-ribose] polymerase 10 1 32703700.0 7285300.0 7273900.0 18144500.0 True False 11052332.72677251 5975815.713759904 14558231.62198315 1.0 0.540683660317649 1.3172089532482278 23.397847563979024 -6.746423769550408 1.6628960208378842 0.7287630045100164 1.3183577957143173 0.633510530414451 0.19298405420795442 0.3063278434049053 1.66540949666064 0.09171824945064418 0.22352568575695264 1.7929832418896218e-07 6.746423769550408 0.5895947912043009 NATVYGK(ub)GVYFAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NATVYGKGVYFAR 13 1 E9PK67;E9PNI7;Q53GL7 E9PK67 PARP10 Poly [ADP-ribose] polymerase 10 1 16257200.0 2583200.0 2503900.0 11170100.0 True False 3538278.84835515 2393269.4187099687 8531952.435430715 1.0 0.676393670844381 2.411328445579406 21.75461631924247 -6.8584992870263015 1.1932571571501671 0.8250685270767442 2.492979650711192 0.9517901535347856 0.16539073095931428 0.14836096098134788 0.4022575268118306 0.10816602905485462 0.2520868501221357 1.3851624599197173e-07 6.8584992870263015 1.667911123634448 up NATVYGK(ub)GVYFAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NATVYGKGVYFAR 13 1 E9PK67;E9PNI7;Q53GL7 E9PK67 PARP10 Poly [ADP-ribose] polymerase 10 1 16768900.0 2973600.0 8106400.0 5688900.0 True False 2472680.152815925 8062729.214205591 6878422.6874983385 1.0 3.260724685731648 2.7817680663894553 21.237644205012664 -9.988064776310136 5.322262972446982 0.9999916855797516 3.0212463760667343 0.9595889305140605 0.19553322107445553 1.9291078555847623e-05 3.6680871101421246e-06 0.18932500380783118 0.06310807573451158 1.02786297788078e-10 9.988064776310136 2.0212546904869826 NATVYGK(ub)GVYFAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NATVYGKGVYFAR 13 1 E9PK67;E9PNI7;Q53GL7 E9PK67 PARP10 Poly [ADP-ribose] polymerase 10 1 20579900.0 7285300.0 9783300.0 3511300.0 True False 9430964.464732504 9238850.75478812 2872279.4289804734 1.0 0.9796294736701849 0.3045583980007014 23.168973886071473 -6.9133429928154015 0.872671867333987 1.0187573059997428 0.21078224217920694 0.9921228139589905 0.02867980652434986 0.10224870808501466 0.12708775953227455 0.023875712223393547 0.06753801937573987 1.2208351002120949e-07 6.9133429928154015 -0.8079750638205359 down NAVIPQYQALFSMDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAVIPQYQALFSMDK 15 0 O76031 O76031 CLPX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial 0 5263200.0 1385500.0 1884000.0 1993700.0 False True 1816403.917201085 1602914.543774482 1787411.0489208149 1.0 0.88246591443407 0.9840383143827692 20.792653622474376 -10.135615455240886 4.939399280641329 1.00000358836915 0.933252114408197 0.3653967166108052 0.04146675863813867 1.6386664850994454e-06 2.8673231920268294e-07 0.04015217445480943 0.013383338802116115 7.317867551104931e-11 10.135615455240886 -0.06675147396095304 NAVIPQYQALFSMDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAVIPQYQALFSMDK 15 0 O76031 O76031 CLPX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial 0 5226300.0 1385500.0 1619100.0 2221700.0 False True 1897756.79172966 1547562.8083522937 1696980.2173477765 1.0 0.8154695138473507 0.8942032112561215 20.855863683997267 -10.104730900737911 4.431289362134464 1.0000145648844716 0.8548363625425378 0.8192482842021286 0.032142897403129 44769428.87407582 0.644656783351029 7151.3213228888135 0.011003368726909562 7.857223361856203e-11 10.104730900737911 -0.1451782023419338 NAVITVPAYFNDSQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAVITVPAYFNDSQR 15 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 36278000.0 10139000.0 12733000.0 13406000.0 False True 13292327.186215661 10833286.032845251 12018875.719432417 1.0 0.8150029623164503 0.904196500060288 23.664090374250094 -10.087315484378344 4.423135139930286 1.0000125824693014 0.8595997311777155 0.7676447618555857 0.03641310933835679 50629676.12312587 0.9417988220331548 6649.535533087213 0.012465175853396154 8.178704469639747e-11 10.087315484378344 -0.14041285129158587 NAVITVPAYFNDSQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAVITVPAYFNDSQR 15 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 30739000.0 10838000.0 6215000.0 13686000.0 False True 10493953.622421253 8696681.910796843 10101226.02880077 1.0 0.8287326420249865 0.9625758214919699 23.32305498339002 -10.457953678195624 4.872236313116251 1.0002385047695688 0.8956542317584651 0.44763388409148985 0.0546412492076891 0.00014188491998326296 1.5785069781925906e-05 0.05302672109521639 0.01763538734977266 3.4837447063936013e-11 10.457953678195624 -0.10458427301110362 NAVITVPAYFNDSQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAVITVPAYFNDSQR 15 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 48885000.0 10139000.0 17475000.0 21271000.0 False True 13887662.296172516 16702896.717902755 16247227.889996216 1.0 1.202714781054701 1.169903727747902 23.727300435772985 -10.196367381587285 4.8644335125929015 0.9999770378379202 1.186309254401755 0.9772675465636992 0.013395056422393819 3.3361876712347414e-06 5.511504789949134e-07 0.012971305227969491 0.004323235870229056 6.362570659290388e-11 10.196367381587285 0.1863322165638348 NAVITVPAYFNDSQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAVITVPAYFNDSQR 15 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 20309200.0 10838000.0 4719700.0 4751500.0 False True 9012277.204808632 4694274.039312896 5745016.68154622 1.0 0.5208754605116005 0.6374655984262093 23.103460258824295 -9.987667986947706 7.09630792578436 1.000000027560459 0.5791705294689293 0.9455666862931196 0.04759772448858643 2.0765139367884798e-08 2.999999942264487e-09 0.04608630199910289 0.015362099521805152 1.0288025050483369e-10 9.987667986947706 -0.4208294980915297 NAVIVALSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAVIVALSSK 10 0 P61086;P61086-2 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 0 26119500.0 6566100.0 6110400.0 13443000.0 False True 8608220.686202843 5198752.138152654 12052047.314361496 1.0 0.6039287708417088 1.4000625394837263 23.037283633604545 -6.771431123525519 1.5689103862672407 0.7732400588317092 1.4047915716648356 0.7360271889260436 0.16699052794863356 0.2641220795212556 1.2832420892151966 0.0838853390154716 0.19942622426215414 1.6926566682464947e-07 6.771431123525519 0.6315515128331264 NAVIVALSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAVIVALSSK 10 0 P61086;P61086-2 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 0 17897400.0 4559800.0 3115600.0 10222000.0 False True 4415051.644908332 4359675.327639364 7544551.546573259 1.0 0.9874573795002305 1.7088252082564037 22.073998883170137 -6.9029472968810595 0.9424777305427877 0.972384436809357 1.7892366230989467 0.9879754087107403 0.036969507119024074 0.10926779049289384 0.165450549648076 0.029249254767524935 0.07728828512632746 1.2504107626283925e-07 6.9029472968810595 0.8168521862895897 NAVIVALSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NAVIVALSSK 10 0 P61086;P61086-2 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 0 50522300.0 8122300.0 27344000.0 15056000.0 False True 12322122.919668982 22464249.56035286 12080175.000720784 1.0 1.8230827355645574 0.980364753660914 23.55474749669178 -10.39547017004155 3.690121419849445 0.9976401230499465 1.4017237446850739 0.23253478023162355 0.34403817569488293 41519725.70428487 31237516.447998583 730335.9977495607 0.11777341700514082 4.022812861492906e-11 10.39547017004155 0.40408362163512734 NAVIVALSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAVIVALSSK 10 0 P61086;P61086-2 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 0 21451000.0 6566100.0 7656900.0 7228000.0 False True 8993764.612180524 7318592.840017712 5520895.265332743 1.0 0.8137407588037076 0.613858100962041 23.100493695127437 -6.970226439065622 0.2527195790855237 1.061348483098396 0.3603757274355366 0.9999840939768939 0.0006288164310252655 0.07622931034014323 0.008766879732457124 0.004377224534143327 0.019072899653846054 1.0709607658195047e-07 6.970226439065622 -0.7009727556628593 NAVIVALSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAVIVALSSK 10 0 P61086;P61086-2 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 0 10384600.0 4559800.0 2070800.0 3754000.0 False True 3791675.7333905213 2059644.1893783852 4538944.043465123 1.0 0.5432015642162124 1.1970812808421234 21.854404158604414 -6.718855279209384 1.7631836416855942 0.7217580958098117 1.1960156021646786 0.5072498377366289 0.19224930416760352 0.35753286557818487 2.1715688224348053 0.08659198692360112 0.21769208216649472 1.9104897887135789e-07 6.718855279209384 0.47425750635486696 NAVIVALSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAVIVALSSK 10 0 P61086;P61086-2 P61086 UBE2K Ubiquitin-conjugating enzyme E2 K 0 41479300.0 8122300.0 21644000.0 11713000.0 False True 10514477.46446912 20439492.373394877 9581354.185529104 1.0 1.9439380076151862 0.9112534805373583 23.325873818784228 -6.666245361044021 1.9509154319888404 1.6044463298534966 0.9155072379362458 0.2624764561586431 0.40131434035229624 0.4697633492754027 3.4433577925427783 0.16582906150942314 0.44519662562728646 2.1565257040630077e-07 6.666245361044021 -0.6889390919172508 NAVLAIYTIYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAVLAIYTIYR 11 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 13389900.0 4018500.0 5600000.0 3771400.0 False True 5268292.415209356 4764501.828629026 3381171.705823318 1.0 0.9043730782433591 0.6417965138119529 22.328903993556494 -6.9534220882050075 0.5199199646635397 1.004464622349165 0.5299886893216726 0.9994431906374672 0.0035734443573339205 0.08214002688673246 0.030495496500715175 0.0040487712530237994 0.021688791360665986 1.113212083509097e-07 6.9534220882050075 -0.47447593302749225 NAVLAIYTIYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAVLAIYTIYR 11 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 18338100.0 8198700.0 4299600.0 5839800.0 False True 7938436.756241477 6016452.702117788 4310181.189755279 1.0 0.7578888497647149 0.5429508758593389 22.920423507919136 -6.9725304725680415 0.18817053010446627 1.149201763424481 0.14577730138893277 0.9999959814348136 0.00037421981967507485 0.0754898286676374 0.005990137682390689 0.007707992148437984 0.02355067753895055 1.0652941139582785e-07 6.9725304725680415 -1.0034244620355484 NAVLAIYTIYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NAVLAIYTIYR 11 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 60181000.0 14293000.0 22847000.0 23041000.0 False True 21683525.958266567 18769774.345574245 18486936.250770934 1.0 0.8656237173649569 0.8525798011980162 24.37009603662722 -13.999999999999968 0.32979817702590813 2.4609980040327906 0.8502642694457205 0.999714415734006 0.00112603546578301 18.805832169459435 0.18362547454360728 19.055716620625162 0.004183029574030564 1.0000000000000737e-14 13.999999999999968 -1.61073373458707 NAVLAIYTIYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAVLAIYTIYR 11 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 24124600.0 4018500.0 7001100.0 13105000.0 False True 5504248.045879207 6691768.2524582995 10009868.905947076 1.0 1.2157461285684859 1.8185715510115925 22.392114055079386 -6.953037247625911 0.5244443932126828 0.9900970606141528 2.0713275701495695 0.9994185663945948 0.008352980003458056 0.08228864314426447 0.031089172704777752 0.009397286950306394 0.0498169763563632 1.1141989692963628e-07 6.953037247625911 1.0812305095354167 NAVLAIYTIYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAVLAIYTIYR 11 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 15465700.0 8198700.0 3045600.0 4221400.0 False True 6817582.313993775 3029192.748295733 5104075.222451696 1.0 0.44432067099182787 0.7486635272411845 22.700828783353412 -10.124007009894164 5.422713468005195 1.0000071712201895 0.5964920991163737 0.7009371434261842 0.12424745077918897 1.0772244002268729e-05 1.740235001601207e-06 0.12030421457426205 0.04010069230630468 7.516107622628255e-11 10.124007009894164 -0.40351507210381576 NAVLAIYTIYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAVLAIYTIYR 11 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 55638000.0 14293000.0 22082000.0 19263000.0 False True 18502570.257150926 20853117.288361937 15757331.655071044 1.0 1.1270389464027337 0.8516293377662547 24.14122235871967 -6.78123986814873 1.5307179848900494 1.071813987811424 0.8493488878030047 0.7718944839713955 0.053753303255377444 0.2486319993858321 1.1507096014447042 0.027654547154069502 0.06519461959409183 1.6548557063658066e-07 6.78123986814873 -0.22246510000841924 NAVLEADFAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAVLEADFAKR 11 1 Q99436;Q5TBG5;Q99436-2 Q99436 PSMB7 Proteasome subunit beta type-7;Proteasome subunit beta type 1 10058380.0 4611460.0 1692920.0 3754000.0 True False 6316441.382020691 1618121.1966621983 2867382.5160568748 1.0 0.2561760806121097 0.453955374970894 22.590680557083967 -10.385591751111825 5.276744822089918 1.0003693515367005 0.3550657277926327 0.9341141787741396 0.08074305881119084 0.0003510368101897337 4.087372100451266e-05 0.07822230734590796 0.026059710174789186 4.115363949876531e-11 10.385591751111825 -0.6453036237440678 NAVLEADFAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAVLEADFAKR 11 1 Q99436;Q5TBG5;Q99436-2 Q99436 PSMB7 Proteasome subunit beta type-7;Proteasome subunit beta type 1 21803880.0 7003800.0 5284600.0 9515480.0 True False 5823970.020948401 5256130.810889025 11505122.873391459 1.0 0.90249963375208 1.9754776951131892 22.473571498566074 -6.8846996063584225 1.053212044456544 0.9348117133155027 2.0587277598109743 0.9772838862470309 0.07301770595773453 0.1235498599279621 0.24780509405759915 0.053157797503480056 0.13023333847385088 1.3040684671581066e-07 6.8846996063584225 1.1239160464954716 NAVLEADFAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAVLEADFAKR 11 1 Q99436;Q5TBG5;Q99436-2 Q99436 PSMB7 Proteasome subunit beta type-7;Proteasome subunit beta type 1 101354500.0 5216500.0 14430000.0 81708000.0 True False 6752862.082587834 13626957.815010559 66837982.39487852 1.0 2.0179529284549567 9.89772656059708 22.687067662184884 -6.9307141776792385 0.7409067018695978 0.883292393824524 11.545221170982206 0.996676756344143 0.22922242188823733 0.09226866500517106 0.07587592113030818 0.20972685746678 0.7102040613885533 1.1729670766514589e-07 6.9307141776792385 10.661928777157682 NAVWALSNLCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAVWALSNLCR 11 0 O60684;Q5TFJ7;O15131;P52294;C9JYI4 O60684;P52294 KPNA6;KPNA5;KPNA1 Importin subunit alpha-7;Importin subunit alpha-6;Importin subunit alpha-5;Importin subunit alpha-5, N-terminally processed 0 13104600.0 3116400.0 3413100.0 6575100.0 False True 4085630.5792605327 2903878.7841595956 5894771.724812784 1.0 0.7107541241981733 1.442805855902834 21.96212733150516 -6.799497124431791 1.457873389654323 0.8403099314740758 1.4527981168241109 0.8307254132629055 0.12385794444491136 0.22146860941151356 0.9293316106873294 0.06683668851725828 0.1554916932715865 1.5867294250339132e-07 6.799497124431791 0.612488185350035 NAVWALSNLCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAVWALSNLCR 11 0 O60684;Q5TFJ7;O15131;P52294;C9JYI4 O60684;P52294 KPNA6;KPNA5;KPNA1 Importin subunit alpha-7;Importin subunit alpha-6;Importin subunit alpha-5;Importin subunit alpha-5, N-terminally processed 0 10165300.0 3116400.0 2841500.0 4207400.0 False True 4268617.297543356 2715953.1344160605 3213698.7741229893 1.0 0.6362606308087461 0.7528664553677636 22.025337393028053 -10.76090753626187 10.19276554875745 1.0011166252542134 0.6945635430882551 0.9014612446421361 0.04760412853434806 0.0012115267970467284 2.841885977731193e-05 0.04622927191029219 0.015364166418687287 1.734173173676433e-11 10.76090753626187 -0.30655308216595833 NAYAVLYDIILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NAYAVLYDIILK 12 0 Q06323;H0YKK6 Q06323 PSME1 Proteasome activator complex subunit 1 0 70504000.0 15442000.0 35823000.0 19239000.0 False True 23426642.961418353 29430105.763623506 15436403.21724674 1.0 1.256266457472901 0.6589251068823286 24.48164689498487 -6.790090595534837 1.4957240980003426 1.14320539208186 0.6525323979425348 0.8017266483262243 0.10895151762258326 0.23519557601881302 1.0394414431876673 0.057332343051687835 0.13423447892954754 1.621471816686705e-07 6.790090595534837 -0.4906729941393251 NAYAVLYDIILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NAYAVLYDIILK 12 0 Q06323;H0YKK6 Q06323 PSME1 Proteasome activator complex subunit 1 0 47341000.0 15442000.0 18782000.0 13117000.0 False True 19989973.407326993 17736765.18929507 10729840.591785628 1.0 0.8872830807665782 0.5367611238468574 24.25277321707732 -6.950640136551378 0.5517711784331376 1.0047974929692598 0.4027295971245334 0.9992505653429735 0.0053998198639748675 0.08322971322844984 0.034906411459429305 0.005847588733215722 0.029088615349864625 1.1203658522579632e-07 6.950640136551378 -0.6020678958447264 NAYVWTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NAYVWTLK 8 0 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7;C9JTT6 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 20699700.0 4960600.0 5263100.0 10476000.0 False True 6503394.638518728 4477865.99540312 9392044.012887811 1.0 0.6885428678864611 1.4441756244131339 22.632761541273826 -6.794776707527158 1.4770595657985017 0.8269943746471288 1.453316524069352 0.8164334393499422 0.13284752262157354 0.22832497214017206 0.9838828280929665 0.07077292497489601 0.16514886445524934 1.6040699111237455e-07 6.794776707527158 0.6263221494222232 NAYVWTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NAYVWTLK 8 0 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7;C9JTT6 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 12338900.0 4379400.0 1412000.0 6547500.0 False True 4240378.344162363 1975818.9634827233 4832513.329210363 1.0 0.4659534605450456 1.1396420170533086 22.01576156309737 -6.695428360480918 1.8469462293047376 0.6669110249045279 1.137490835859292 0.3960385090911285 0.2256206644581975 0.4050977757944475 2.6831772379939824 0.0975717161932688 0.2523756311600121 2.0163765568227282e-07 6.695428360480918 0.470579810954764 NAYVWTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NAYVWTLK 8 0 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7;C9JTT6 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 18043500.0 4960600.0 5262800.0 7820100.0 False True 6794667.8751744125 5030272.094247703 5973153.440015017 1.0 0.7403264128077167 0.8790942470991184 22.695971602796718 -10.164327048579349 4.930178924743287 1.0000144343768451 0.809710329952938 0.714873463429847 0.05665173112249639 8.988972714909704e-06 1.5235852149860946e-06 0.05485696237423164 0.018284267597367242 6.84972208939265e-11 10.164327048579349 -0.1903041044239071 NAYVWTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NAYVWTLK 8 0 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7;C9JTT6 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 11162800.0 4379400.0 3367200.0 3416200.0 False True 3641665.140315461 3349060.225263126 4130511.6252758554 1.0 0.9196507905647284 1.1342370773052592 21.796166838531647 -6.805322528224203 1.4343947211364916 0.9559622273198698 1.1375923598271842 0.8471766394004965 0.034604978196399336 0.21325651620708788 0.8656524566925217 0.018975700856969438 0.043989136181074605 1.565587956438163e-07 6.805322528224203 0.1816301325073144 NCAAYLK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NCAAYLKLR 9 1 P35579;P35579-2;P35749-2;P35749;P35749-3;P35749-4;Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4;M0QY43;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;Q7Z406;P35580 MYH9;MYH11;MYH14;MYH10 Myosin-9;Myosin-11;Myosin-14;Myosin-10 1 31369700.0 14147400.0 3742700.0 13479600.0 True False 21462640.113480754 3074785.9431514298 10815351.151681453 1.0 0.14326224205847568 0.5039152263885884 24.355324216743618 -10.621402941249654 6.482258628261697 1.0023770963294238 0.3235887344143678 0.8242559098328942 0.1472359643034589 0.0050694927296614225 0.00029608393303687616 0.14288122308348625 0.04752020314250718 2.3910962522490325e-11 10.621402941249654 -0.6787883619150561 NCAVEFNFGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NCAVEFNFGQR 11 0 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;Q9BUJ2-3;M0QYZ0 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 0 25760900.0 7871500.0 6810400.0 11079000.0 False True 10319612.727714427 5794314.866731284 9932651.357272256 1.0 0.5614856893970478 0.9625023360224609 23.29888549482838 -10.41962588134253 8.691932911062947 1.000002147904558 0.7619940127097544 0.3195735795767508 0.16371436043237597 6.81443713896489e-06 4.550605097853538e-07 0.1585171778213049 0.05283858262413259 3.8051704779653175e-11 10.41962588134253 -0.23800813519480357 NCAVEFNFGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NCAVEFNFGQR 11 0 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;Q9BUJ2-3;M0QYZ0 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 0 28290100.0 7871500.0 8684600.0 11734000.0 False True 10781806.269289078 8300885.655868282 8962670.869315773 1.0 0.7698974966293489 0.8312773059969614 23.36209555635127 -10.314745772036009 5.271313527890181 1.000048703784734 0.8005874013131405 0.9336570824166197 0.025058202243376758 1.4346255825850209e-05 1.8650146359756475e-06 0.02426841715482656 0.008087499997867242 4.8445587611286114e-11 10.314745772036009 -0.19946130247159355 NCEK(ub)SMVEQLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NCEKSMVEQLDK 12 1 Q9P287-4;Q9P287-3;Q9P287;Q9P287-2 Q9P287-4 BCCIP BRCA2 and CDKN1A-interacting protein 1 11384600.0 2155200.0 2956400.0 6273000.0 True False 2825488.0709864916 2515316.6439569397 5623930.134864955 1.0 0.8902237704648108 1.9904278459407598 21.4300686675679 -6.882346082281527 1.0665816217467898 0.9295910792176562 2.072008212770329 0.9755310266596583 0.07739946108519735 0.12557428687198188 0.2598752650273536 0.055775472584156334 0.13572585813589488 1.3111546445714861e-07 6.882346082281527 1.142417133552673 NCEK(ub)SMVEQLDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NCEKSMVEQLDK 12 1 Q9P287-4;Q9P287-3;Q9P287;Q9P287-2 Q9P287-4 BCCIP BRCA2 and CDKN1A-interacting protein 1 23632500.0 7196600.0 8875000.0 7560900.0 True False 10917768.341933908 7291186.9093085 6066484.8009398095 1.0 0.6678275890232878 0.5556524567057474 23.38017465498802 -13.999999999999908 0.15159669832083475 2.610269882729818 0.43447472856255154 0.999560997180244 0.003953078989086755 11.964082013899477 0.1227025092006907 5.672514535058174 0.1093952721925425 1.0000000000002127e-14 13.999999999999908 -2.1757951541672664 NCEK(ub)SMVEQLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NCEKSMVEQLDK 12 1 Q9P287-4;Q9P287-3;Q9P287;Q9P287-2 Q9P287-4 BCCIP BRCA2 and CDKN1A-interacting protein 1 11360100.0 2155200.0 3494000.0 5710900.0 True False 2952035.682090054 3339623.526887106 4362103.03967747 1.0 1.1312951083716705 1.4776593203606139 21.493278729090793 -6.954299858425545 0.5094589119165236 0.9935969820065274 1.6305389022490884 0.9994969353646369 0.004519118771348171 0.0818037462884313 0.029162264596236897 0.0052100144378729 0.028585238349967186 1.1109643975528568e-07 6.954299858425545 0.636941920242561 NCEK(ub)SMVEQLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NCEKSMVEQLDK 12 1 Q9P287-4;Q9P287-3;Q9P287;Q9P287-2 Q9P287-4 BCCIP BRCA2 and CDKN1A-interacting protein 1 28394600.0 7196600.0 8171000.0 13027000.0 True False 9316140.566194115 7716276.667113734 10656219.668307643 1.0 0.8282696694287893 1.1438448778860564 23.15130097708047 -6.758936688588077 1.6165585741992992 0.9001173488235575 1.144934201429237 0.6865816267894045 0.07221940700921493 0.2847060404089702 1.4661457845019301 0.03525351307030764 0.08480602925694175 1.7420608123557725e-07 6.758936688588077 0.24481685260567942 NCELDK(ub)NQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NCELDKNQR 9 1 Q01668-2;Q01668-3;A0A5F9Z6M3;A0A1B0GTN0;A0A1B0GUN6;A0A1B0GUB6;A0A1W2PQ56;A0A1B0GWE1;Q59GD8;Q01668-4;Q01668;A0A1B0GTP8;Q13936;F5GY28;Q13936-34;Q13936-8;A0A0A0MSA1;A0A1B0GWF7;A0A0A0MR67;Q13936-33;Q13936-3;E9PDI6;Q13936-28;Q13936-36;Q13936-18;Q13936-12;Q13936-31;Q13936-5;F5H522;Q13936-2;Q13936-6;Q13936-30;Q13936-7;Q13936-4;Q13936-11;Q13936-21;Q13936-17;Q13936-19;Q13936-35;Q13936-37;Q13936-22;Q13936-20;Q13936-32;Q13936-16;Q13936-23;Q13936-25;Q13936-27;Q13936-14;Q13936-29;Q13936-13;Q13936-9;Q13936-15;Q13936-26;Q13936-10;Q13936-24;A0A1B0GVI2;Q13698;B1ALM3 Q01668-2 CACNA1D;CACNA1C;CACNA1S Voltage-dependent L-type calcium channel subunit alpha-1D;Voltage-dependent L-type calcium channel subunit alpha-1C;Voltage-dependent L-type calcium channel subunit alpha-1S 1 3957720.0 432670.0 674050.0 2851000.0 True False 418935.12768158456 943201.6801243133 2104237.571833334 1.0 2.251426576100351 5.0228243773166685 18.676367333592943 -6.95800358460121 0.46271147179794103 0.9213692981108935 6.465111609600595 0.999688840429686 0.0296511846195777 0.08042212768235214 0.023825750122903007 0.03781521507911897 0.22888071508414126 1.1015302176394666e-07 6.95800358460121 5.5437423114897015 NCGFVAFMNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NCGFVAFMNR 10 0 E7ET15;O15042-2;O15042;E7EW00;H0Y8D9 E7ET15 U2SURP U2 snRNP-associated SURP motif-containing protein 0 20472700.0 5480800.0 5080900.0 9911000.0 False True 7185381.876142694 4322849.525193079 8885504.793025112 1.0 0.6016172278255726 1.2366085680883936 22.776633401883903 -6.737118388758735 1.6974860766565776 0.7621740097037434 1.236734861930178 0.5918489581414108 0.16739811531754725 0.3230472986526056 1.8266213995532554 0.07805492390651277 0.19213127761639756 1.8318150011838732e-07 6.737118388758735 0.4745608522264345 NCGFVAFMNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NCGFVAFMNR 10 0 E7ET15;O15042-2;O15042;E7EW00;H0Y8D9 E7ET15 U2SURP U2 snRNP-associated SURP motif-containing protein 0 15860600.0 5480800.0 4915800.0 5464000.0 False True 7507199.873050824 4698603.701623248 4173515.734612355 1.0 0.6258796596704703 0.5559350763517497 22.839843463406794 -13.999999999999998 0.23580940008903234 3.426988967136719 0.5237541901949865 0.9995182539260482 0.004278913083759985 13.479142810668124 0.15371677799827088 15.367434866244098 0.03503971390989054 1.0000000000000041e-14 13.999999999999998 -2.9032347769417326 NCGFVAFMNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NCGFVAFMNR 10 0 E7ET15;O15042-2;O15042;E7EW00;H0Y8D9 E7ET15 U2SURP U2 snRNP-associated SURP motif-containing protein 0 13307100.0 3720300.0 5526900.0 4059900.0 False True 4816001.68807659 5219323.1564644305 3321039.8580918238 1.0 1.0837461227196783 0.6895844464328204 22.19940446710686 -6.851160739096642 1.2293825327795775 1.0447404402671516 0.6734628765813174 0.9419886974660207 0.04083780128456695 0.15618573400017266 0.4536532917846701 0.025984329631019123 0.06017902180523918 1.408767295381302e-07 6.851160739096642 -0.3712775636858342 NCGQTVHDEVANK(ub)QTMEELK ddPTM_RPMI8226_Bortezomib_1h_R1 2 NCGQTVHDEVANKQTMEELK 20 1 O14964;O14964-2;I3L1P5;I3L2H4;I3L165 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 68872500.0 21782600.0 31424800.0 15665100.0 True False 28557199.542998467 26736342.332910974 14044225.722249797 1.0 0.9362382432722146 0.49179282096983845 24.767351172866963 -6.932751596688413 0.723847212667194 1.006116908374156 0.3938088855542391 0.9970519854823793 0.01227331584919266 0.0912339962381859 0.0708633413672002 0.011370546450585304 0.039623742863892794 1.1674771877772269e-07 6.932751596688413 -0.6123080228199168 down NCGQTVHDEVANK(ub)QTMEELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NCGQTVHDEVANKQTMEELK 20 1 O14964;O14964-2;I3L1P5;I3L2H4;I3L165 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 33456100.0 14701000.0 8667100.0 10088000.0 True False 14234324.80192057 12127918.228329401 7445650.166487085 1.0 0.8520192139140339 0.5230771582142398 23.76287072539684 -6.957927132103788 0.46372443893311055 1.0092396586844232 0.35251327260480203 0.9996854257057195 0.0035351852194827373 0.0804500636834128 0.02393139881875761 0.004496365115485742 0.027163583252775292 1.1017241463044195e-07 6.957927132103788 -0.6567263860796212 NCGQTVHDEVANK(ub)QTMEELK ddPTM_RPMI8226_Bortezomib_8h_R1 2 NCGQTVHDEVANKQTMEELK 20 1 O14964;O14964-2;I3L1P5;I3L2H4;I3L165 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 147662900.0 31517800.0 70275500.0 45869600.0 True False 47814806.85982328 57734287.960012354 36803453.454640105 1.0 1.207456262016693 0.7697082948078258 25.51095411244547 -6.777810109316518 1.5441603242367496 1.1178005115205143 0.7664610216340993 0.7596435524241661 0.08765431148193652 0.25399329492280004 1.196039629769527 0.04471413982524276 0.10571203397996776 1.6679763582111129e-07 6.777810109316518 -0.35133948988641495 NCGQTVHDEVANK(ub)QTMEELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NCGQTVHDEVANKQTMEELK 20 1 O14964;O14964-2;I3L1P5;I3L2H4;I3L165 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 50761500.0 18840800.0 13691600.0 18229100.0 True False 25806752.91347542 13086659.839933457 13923762.020099206 1.0 0.5071021481784345 0.5395394789411373 24.621245292651295 -9.944945018220054 5.382490057666772 1.000000998626828 0.5233208135579005 0.9965390644340195 0.013242484837698897 1.586918864145213e-07 3.1095527711633236e-08 0.0128220077446255 0.004273993602277787 1.1351545173952461e-10 9.944945018220054 -0.4766801850689274 NCGQTVHDEVANK(ub)QTMEELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NCGQTVHDEVANKQTMEELK 20 1 O14964;O14964-2;I3L1P5;I3L2H4;I3L165 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 38667800.0 14701000.0 9888100.0 14078700.0 True False 12224532.864725223 9834830.842665823 17022491.07744606 1.0 0.8045158822424161 1.3924860169148625 23.543276000831117 -6.817075278335292 1.3843947882199146 0.8943114876060816 1.4045427257513983 0.8775366714447095 0.08555789158535942 0.1973140376880746 0.7438300701023562 0.04857374827548033 0.11205602390972078 1.5237886053533942e-07 6.817075278335292 0.5102312381453167 NCGQTVHDEVANK(ub)QTMEELK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NCGQTVHDEVANKQTMEELK 20 1 O14964;O14964-2;I3L1P5;I3L2H4;I3L165 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 121984700.0 31517800.0 60039000.0 30427900.0 True False 40800413.40871976 56697776.87147731 24890334.41661921 1.0 1.389637313316046 0.6100510347108324 25.28208043453792 -6.770828486890937 1.5713222540273137 1.223256077040659 0.6055353245124543 0.7336627211296085 0.16424968747662025 0.2651153293282778 1.291965626207146 0.0823872145851494 0.1959638891825016 1.6950070664551597e-07 6.770828486890937 -0.6177207525282048 NCGQTVHDEVANK(ub)QTMEELKDLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NCGQTVHDEVANKQTMEELKDLLK 24 2 O14964;O14964-2;I3L1P5;I3L2H4;I3L165 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 154446000.0 35822000.0 68575000.0 50049000.0 True False 54344592.93899296 56337255.4710795 40156793.212743975 1.0 1.036667171917609 0.7389289539407139 25.695633164447408 -6.876069320180407 1.1014465374497042 1.021735199520839 0.719353307750821 0.9703759982677983 0.0228158179072955 0.13117078330898682 0.2937886176685953 0.01600876617216739 0.03835622788491736 1.33024207362639e-07 6.876069320180407 -0.30238189177001806 NCHLNENIEK(ub)GLLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NCHLNENIEKGLLHR 15 1 Q13907;Q13907-2;Q9BXS1 Q13907 IDI1;IDI2 Isopentenyl-diphosphate Delta-isomerase 1;Isopentenyl-diphosphate delta-isomerase 2 1 9879700.0 6214600.0 1805800.0 1859300.0 True False 5167715.253460392 1796071.796976764 2248071.033568113 1.0 0.3475562620781172 0.435022233870716 22.3010951475336 -10.710911164709817 6.86008205608948 1.0063275825273055 0.39128924797615905 0.9847509085009799 0.03570783345808892 0.0034570173392443246 0.0001456810698422367 0.03458742148960503 0.011524653692693869 1.945758047313363e-11 10.710911164709817 -0.6150383345511464 NCIISLVTQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NCIISLVTQR 10 0 Q13868;Q13868-3;A3KFL2;Q13868-2;A3KFL5 Q13868 EXOSC2 Exosome complex component RRP4 0 18938000.0 5934400.0 5323600.0 7680000.0 False True 7780055.868811347 4529339.631230265 6885347.2717619715 1.0 0.5821731498596895 0.8849997208071373 22.891349084608606 -9.941369169874008 5.495146944929442 1.00000040571808 0.7335864353327498 0.5078646624784573 0.12362842989866474 6.144356326335249e-07 1.184783453052431e-07 0.11970289446311681 0.039900904175936336 1.1445396175846412e-10 9.941369169874008 -0.2664139703853302 NCIISLVTQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NCIISLVTQR 10 0 Q13868;Q13868-3;A3KFL2;Q13868-2;A3KFL5 Q13868 EXOSC2 Exosome complex component RRP4 0 21053700.0 5934400.0 6744000.0 8375300.0 False True 8128508.051129915 6446027.780574302 6397226.634717942 1.0 0.7930148730895656 0.7870111703744559 22.954559146131498 NCIISLVTQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NCIISLVTQR 10 0 Q13868;Q13868-3;A3KFL2;Q13868-2;A3KFL5 Q13868 EXOSC2 Exosome complex component RRP4 0 7388700.0 3832600.0 3556100.0 0.0 False True 4961376.251840535 3358199.908936872 0.0 1.0 0.6768686224293253 0.0 22.24230893918959 -7.47612108882942 0.7254702062359342 0.9923708293991577 3.2910805245376594e-17 0.9871386799339065 0.04725421620209901 0.11792242429699691 0.14146596720006344 0.04151839400994724 0.0750260380864238 3.3410187364497265e-08 7.47612108882942 -0.9923708293991577 down NCIIVSPDAGGAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 NCIIVSPDAGGAKR 14 1 P11908;P11908-2;H7C540;D3YTJ7 P11908 PRPS2 Ribose-phosphate pyrophosphokinase 2 1 9554100.0 2985600.0 1657900.0 4910600.0 True False 4529373.476596984 1362034.7917681755 3940017.7576075597 1.0 0.3007115219810714 0.8698814036787667 22.11088007330028 -10.283734790630508 7.895029059421855 1.0000009179163296 0.5852964628301573 0.41446242504113306 0.23236263118660325 3.754263402680433e-06 3.4056074478203145e-07 0.22498464632791143 0.07499471673888754 5.2031363797862804e-11 10.283734790630508 -0.41470445508617226 NCIIVSPDAGGAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NCIIVSPDAGGAKR 14 1 P11908;P11908-2;H7C540;D3YTJ7 P11908 PRPS2 Ribose-phosphate pyrophosphokinase 2 1 7941400.0 2985600.0 1370200.0 3585600.0 True False 3864918.054974451 1293947.165497397 2933057.591362853 1.0 0.3347929107661121 0.7588925689091336 21.88200639539273 -10.14735579187277 5.715492873404719 1.0000060669029465 0.5468427398379343 0.6035367460936438 0.17313796042329588 1.3384930265359009e-05 1.996995750827504e-06 0.16764235148750042 0.05588003644296429 7.122692708052029e-11 10.14735579187277 -0.45316332706501217 NCIVLIDSTPYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NCIVLIDSTPYR 12 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 181341000.0 44622000.0 61863000.0 74856000.0 False True 58499874.12006264 52633281.54008527 67110619.18945506 1.0 0.899716150364067 1.147192540136413 25.801930184521993 -6.796732732386606 1.4695265694584172 0.9444373643502405 1.1503274341322225 0.8223414531314979 0.04283870544796919 0.22546093950074284 0.9615826989112124 0.022938548079332047 0.0534489439340633 1.5968615637751e-07 6.796732732386606 0.205890069781982 NCIVLIDSTPYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NCIVLIDSTPYR 12 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 44644900.0 24911000.0 8670900.0 11063000.0 False True 24120213.940592024 12133235.588146146 8165268.417114056 1.0 0.5030318395197593 0.3385238803115542 24.52373936787003 -13.999999999999998 0.1545068087876034 3.421255969754327 0.1665858862248842 0.9995519005881544 0.0059522465794413296 11.977551457086873 0.12400834300559249 8.69728193537386 0.15569713196562712 1.0000000000000041e-14 13.999999999999998 -3.254670083529443 NCIVLIDSTPYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NCIVLIDSTPYR 12 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 133285000.0 22058000.0 88401000.0 22826000.0 False True 33463598.655806627 72625150.8698345 18314431.095008783 1.0 2.1702731860021434 0.5472941294623986 24.99608926451059 -6.713210884349246 1.7835855746528422 1.717071825832936 0.5507029836603653 0.48043777347396077 0.49290521367127754 0.36864751302563603 2.287927641821386 0.21975241144631655 0.5561477915310948 1.9354819060527707e-07 6.713210884349246 -1.1663688421725706 NCIVLIDSTPYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NCIVLIDSTPYR 12 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 153483000.0 44622000.0 44602000.0 64259000.0 False True 61119959.26420849 42631336.16090977 49082347.65564694 1.0 0.6975026926412637 0.8030494170238968 25.865140246044884 -10.92848566883436 10.959154640982298 1.0410888108078524 0.7502760548326362 0.8818520610251944 0.043089269793270456 0.024303299803683075 0.00015859177318885027 0.023439497003723123 0.013907002025797893 1.179001428149747e-11 10.92848566883436 -0.2908127559752163 NCIVLIDSTPYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NCIVLIDSTPYR 12 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 70792000.0 22058000.0 27119000.0 21615000.0 False True 28554515.828184094 25609803.810483124 17681291.788629014 1.0 0.8968740343762208 0.6192117525304733 24.76721558660304 -6.95385362869058 0.5148030025186806 1.0049149498538301 0.49888919363571865 0.9994700258899939 0.0037019679922660133 0.08197425292622273 0.02983656006691621 0.00422942523968292 0.02292430314854534 1.1121064800367212e-07 6.95385362869058 -0.5060257562181114 NCLTNFHGMDLTR ddPTM_RPMI8226_Bortezomib_1h_R1 2 NCLTNFHGMDLTR 13 0 P61247;D6RG13;D6RAT0;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7 P61247 RPS3A 40S ribosomal protein S3a 0 59131700.0 9199200.0 24408900.0 25523600.0 False True 12060240.285179509 20767187.265147004 22882662.711659368 1.0 1.7219546853197625 1.8973637481982204 23.52375531562727 -11.05450492590484 0.26723097057932677 1.9128551665288765e-23 1.9689393885593538 0.9992331340956768 0.01075395213141209 3.035010684221175 0.14091977283737844 1.926265001122595 0.07341378517296474 8.820537975478682e-12 11.05450492590484 1.9689393885593538 NCLTNFHGMDLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NCLTNFHGMDLTR 13 0 P61247;D6RG13;D6RAT0;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7 P61247 RPS3A 40S ribosomal protein S3a 0 13672200.0 7395900.0 1752900.0 4523400.0 False True 7161121.202810981 2452842.1112527377 3338585.8409087714 1.0 0.3425220774492568 0.46620993366210084 22.77175405445337 -10.298504163988525 5.871065718041999 1.0000453368478988 0.40436600555872626 0.9686719638304886 0.05049535585004148 2.9967752996316348e-05 3.5807547995460865e-06 0.04889562061847248 0.016297306022334524 5.029164438956934e-11 10.298504163988525 -0.5956793312891725 NCLTNFHGMDLTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NCLTNFHGMDLTR 13 0 P61247;D6RG13;D6RAT0;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7 P61247 RPS3A 40S ribosomal protein S3a 0 79524900.0 4871900.0 71722000.0 2931000.0 False True 7391028.483598902 58922648.7334563 2351686.565297062 1.0 7.97218531415606 0.31818123425117134 22.817343702971137 -6.667024302907602 1.948143791846093 5.461858802916719 0.3497994910276911 0.2657167786016428 2.963724172827947 0.4680753399750958 3.4220084842709513 1.226051221651233 3.288199216541199 2.1526612694780385e-07 6.667024302907602 -5.112059311889028 NCLTNFHGMDLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NCLTNFHGMDLTR 13 0 P61247;D6RG13;D6RAT0;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7 P61247 RPS3A 40S ribosomal protein S3a 0 49944600.0 9199200.0 22259700.0 18485700.0 False True 12600392.839032464 21276192.85101573 14119758.384942096 1.0 1.6885340895966423 1.1205808077033175 23.58696537715016 -10.43339971969588 3.8161227530371056 0.9972157890993044 1.4045574486737389 0.40352262342355993 0.23186595648244793 166726494.6744923 14820.720634051922 4079442.008764514 0.07937381767804433 3.6863815202526424e-11 10.43339971969588 0.40734165957443447 NCLTNFHGMDLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NCLTNFHGMDLTR 13 0 P61247;D6RG13;D6RAT0;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7 P61247 RPS3A 40S ribosomal protein S3a 0 11920700.0 4871900.0 3890200.0 3158600.0 False True 6306770.589506316 3673706.950239367 2583767.2099728654 1.0 0.5825020742552393 0.409681495989712 22.588470025063586 -13.999999999999998 0.12108217471841452 2.9883786143453754 0.13782890528574562 0.9996876485576514 0.00437949660487042 11.95971486479227 0.10722865205287604 5.714280681680319 0.24125934700275764 1.0000000000000041e-14 13.999999999999998 -2.8505497090596297 NCPHIVVGTPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NCPHIVVGTPGR 12 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;A0A140T996;A0A140T9X9;F6UJC5;A0A140TA18;A0A140T9K1;A0A140T973;A0A140T9L4 Q13838-2 DDX39B Spliceosome RNA helicase DDX39B 0 10580900.0 2399100.0 4492700.0 3689100.0 False True 3145243.3329174514 3822406.672407434 3307387.3203459787 1.0 1.2152975995220892 1.0515521281713127 21.584740205383646 -10.347180095530147 4.1011188326206 0.9997219058423971 1.13342486384877 0.46957080857231237 0.06684880877752836 0.0001718081362638022 2.7348548723535915e-05 0.06486170752754714 0.021575360255142246 4.495933764744598e-11 10.347180095530147 0.133702958006373 NCPHIVVGTPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NCPHIVVGTPGR 12 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;A0A140T996;A0A140T9X9;F6UJC5;A0A140TA18;A0A140T9K1;A0A140T973;A0A140T9L4 Q13838-2 DDX39B Spliceosome RNA helicase DDX39B 0 3570970.0 1168300.0 427670.0 1975000.0 False True 1131212.9559950866 598440.8612695866 1457688.251270025 1.0 0.5290258196726186 1.2886063968280403 20.10943911813683 -6.738973763073158 1.6904205698267194 0.719454144368069 1.2889615453271739 0.6004495617664548 0.197886793433288 0.31962084116008127 1.7929135854621696 0.09262432940377932 0.22755123101404373 1.8240058922152287e-07 6.738973763073158 0.5695074009591049 NCPHIVVGTPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NCPHIVVGTPGR 12 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;A0A140T996;A0A140T9X9;F6UJC5;A0A140TA18;A0A140T9K1;A0A140T973;A0A140T9L4 Q13838-2 DDX39B Spliceosome RNA helicase DDX39B 0 11448900.0 2399100.0 4769900.0 4279900.0 False True 3286112.103239721 4559150.046050033 3269075.7673073546 1.0 1.3873994260741274 0.994815655888437 21.647950266906538 -8.874394084206173 13.101322027226797 1.0 1.1911075409813567 0.24009747359795985 0.16027165304243937 0.0 0.0 0.15518236077550185 0.051727453591833936 1.335383223284355e-09 8.874394084206173 0.19110754098135674 NCPHIVVGTPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NCPHIVVGTPGR 12 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;A0A140T996;A0A140T9X9;F6UJC5;A0A140TA18;A0A140T9K1;A0A140T973;A0A140T9L4 Q13838-2 DDX39B Spliceosome RNA helicase DDX39B 0 2389020.0 1168300.0 444890.0 775830.0 False True 971493.2144655769 442493.2892662496 938052.4659673813 1.0 0.4554774883421777 0.9655779906639991 19.889844393571106 -10.641173672779203 9.661155345689307 1.0000988393915282 0.7105277395030886 0.30039565035967686 0.20824765803764136 0.000443493753228 1.6471791027797533e-05 0.20170280014744632 0.06721164262220684 2.2846849834795906e-11 10.641173672779203 -0.28957109988843965 NCPWTVALWSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NCPWTVALWSR 11 0 A0A499FI31;Q15020-4;Q15020 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 12449900.0 3144200.0 4976000.0 4329700.0 False True 4122076.6484761145 4233600.196296085 3881704.17741508 1.0 1.027055185366628 0.9416865595767372 21.97493990082635 -6.821495627867858 1.3655598841065586 1.0145606248404018 0.9397649827189175 0.8877534640928068 0.011934461824235795 0.19154545087689334 0.7014647155383555 0.006867379863338152 0.015820916425254263 1.5083577954131388e-07 6.821495627867858 -0.07479564212148426 NCPWTVALWSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NCPWTVALWSR 11 0 A0A499FI31;Q15020-4;Q15020 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 12233500.0 3144200.0 3911100.0 5178200.0 False True 4306695.708810107 3738294.6697218553 3955215.808376584 1.0 0.8680192245935818 0.918387570379187 22.03814996234924 -10.614830740304242 8.68317294644035 1.000048313237466 0.8932033977390317 0.8570263584591556 0.02056279106046601 1.924088046023036e-05 8.534816560513034e-07 0.019918825412234033 0.006636612277393963 2.4275560139262003e-11 10.614830740304242 -0.10684491549843433 NCSETQYESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NCSETQYESK 10 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 26465560.0 617560.0 14917000.0 10931000.0 False True 809627.1404595472 12691441.746010594 9799964.977556007 1.0 15.67566242753039 12.104294048237454 19.626898127549694 -9.93856066638981 8.367537960081059 0.9999999830715058 13.889978237883923 0.9455603355838115 1.4580050354630383 4.402553215851186e-07 6.033625140152222e-08 1.411707305258586 0.4705691017529084 1.1519651311242638e-10 9.93856066638981 12.889978254812418 NCSETQYESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NCSETQYESK 10 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 6788410.0 3756200.0 902010.0 2130200.0 False True 3636961.48703993 1262187.2969200087 1572236.7153698264 1.0 0.3470444494443312 0.4322940237262306 21.794302218034755 -10.684076898046165 6.764540531994155 1.0044513385819043 0.38966923658705027 0.9855786316309 0.03480299296335753 0.0023421642727566726 0.00010938553550100402 0.033780975973646835 0.011232617678771463 2.0697748331224022e-11 10.684076898046165 -0.6147821019948541 NCSETQYESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NCSETQYESK 10 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 26169560.0 617560.0 13467000.0 12085000.0 False True 845888.6209314829 12871983.410586322 9230771.89838768 1.0 15.217113804429525 10.912514567488635 19.690108189072586 -9.542165620803683 7.114129255275559 0.9999999799298206 13.064814185973253 0.9128468005976001 1.757345279665803 4.2514383113117345e-08 0.0 1.701542250397027 0.5671807501323424 2.8696860013689944e-10 9.542165620803683 12.064814206043433 NCSETQYESK(ub)VFYLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NCSETQYESKVFYLK 15 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 18638600.0 4884200.0 7658100.0 6096300.0 True False 6403233.498660075 6515541.331040003 5465513.355838869 1.0 1.0175392373873966 0.8535552165921435 22.610369189191765 -6.880441177563677 1.0773881388235582 1.010933763985652 0.8418374452793 0.9740372967357881 0.011845962038582864 0.1272376196680351 0.2699593754032948 0.00846667903138094 0.02049683706689697 1.3169182688795982e-07 6.880441177563677 -0.1690963187063519 NCSETQYESK(ub)VFYLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NCSETQYESKVFYLK 15 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 38154900.0 19659000.0 10499000.0 7996900.0 True False 29824140.26541401 8625371.4209386 6416309.209834216 1.0 0.28920771375733956 0.215138111366616 24.82997721444718 -13.999999999999998 0.3195029297776745 8.26656167716482 0.20035133495278104 0.999692660151784 0.00620291781165796 17.974827780846717 0.1802398685976985 87.28593178546824 0.024708445845857935 1.0000000000000041e-14 13.999999999999998 -8.066210342212038 NCSETQYESK(ub)VFYLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NCSETQYESKVFYLK 15 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 14988700.0 4884200.0 6550500.0 3554000.0 True False 6690020.730542042 6261077.250393233 2714618.39692758 1.0 0.9358830865515039 0.4057712982165355 22.673579250714656 -6.9294881709272556 0.7509828918996406 1.008216362950721 0.2983476061024484 0.9964366641709289 0.015896377344855227 0.09290450781463455 0.07898893578751533 0.014438506349790214 0.04810170458352144 1.1762830231943875e-07 6.9294881709272556 -0.7098687568482727 down NCSETQYESK(ub)VFYLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NCSETQYESKVFYLK 15 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 36147200.0 19659000.0 9455700.0 7032500.0 True False 25448963.036824323 8929481.982771682 5752657.159543533 1.0 0.35087802869809803 0.22604681971597473 24.60110353653963 -13.999999999999998 0.2318118310528172 5.132373519632319 0.16638974348418595 0.9995123211679892 0.007492281095263473 13.34839609430736 0.1524347786423104 25.414669211392983 0.06407616746509427 1.0000000000000041e-14 13.999999999999998 -4.965983776148133 NCSSFLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NCSSFLIK 8 0 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 36460900.0 2811700.0 8437200.0 25212000.0 False True 3851261.473335467 8064416.605910673 19257444.85743898 1.0 2.0939675640683815 5.0002953553710965 21.876899644543887 -6.954146165420148 0.5113038428303329 0.9470797899736803 6.274971953068726 0.9994877731040537 0.0382048625034751 0.08186233715079762 0.029393470286836323 0.0439061335449149 0.23988765819765132 1.1113576276785938e-07 6.954146165420148 5.327892163095045 NCSSPEFSK(ub)TLQLEYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NCSSPEFSKTLQLEYR 16 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX45;Q5JX52;Q5JX61;Q5JX55;Q5JX54;E7EV27;Q5JX57 Q99829 CPNE1 Copine-1 1 16264700.0 4170800.0 5684300.0 6409600.0 True False 5467959.190084661 4836224.597227857 5746396.077224676 1.0 0.8844661105001732 1.0509215371696479 22.382571044806152 -6.720042692765058 1.75917086962113 0.9297117765184985 1.0506617492151324 0.5126376161059865 0.048617135507366536 0.3552740785216095 2.1487321247434066 0.021943415032409878 0.05508321577459081 1.9052734132844953e-07 6.720042692765058 0.12094997269663399 NCSSPEFSK(ub)TLQLEYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NCSSPEFSKTLQLEYR 16 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX45;Q5JX52;Q5JX61;Q5JX55;Q5JX54;E7EV27;Q5JX57 Q99829 CPNE1 Copine-1 1 9876900.0 0.0 4633500.0 5243400.0 True False 0.0 6483680.7133832965 3869996.241371771 0.0 NCSSPEFSK(ub)TLQLEYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NCSSPEFSKTLQLEYR 16 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX45;Q5JX52;Q5JX61;Q5JX55;Q5JX54;E7EV27;Q5JX57 Q99829 CPNE1 Copine-1 1 63717000.0 10018000.0 14477000.0 39222000.0 True False 15198038.413902929 11893466.240682721 31469754.50838667 1.0 0.7825658757253017 2.0706458064745137 23.857381793593785 -6.863464278553658 1.1680117394969654 0.880745081069446 2.1373057987018655 0.9577193364397715 0.11576531303305788 0.1432810608200501 0.36947115171663997 0.07718335524877708 0.1809431189120998 1.369417020595712e-07 6.863464278553658 1.2565607176324196 up NCSSPEFSK(ub)TLQLEYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NCSSPEFSKTLQLEYR 16 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX45;Q5JX52;Q5JX61;Q5JX55;Q5JX54;E7EV27;Q5JX57 Q99829 CPNE1 Copine-1 1 17083100.0 4170800.0 5436300.0 7476000.0 True False 5712857.471631959 5196106.290559928 5710322.773053065 1.0 0.9095459350004729 0.9995563168534345 22.445781106329044 -9.944005027376205 4.401664101031103 1.0000009182543743 0.9545511260126115 0.253696836949004 0.03674658456699509 50372653.25978561 1260.4109651831614 521.7147036651456 0.012579333291392769 1.1376141167699836e-10 9.944005027376205 -0.04544979224176282 NCSSPEFSK(ub)TLQLEYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NCSSPEFSKTLQLEYR 16 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX45;Q5JX52;Q5JX61;Q5JX55;Q5JX54;E7EV27;Q5JX57 Q99829 CPNE1 Copine-1 1 13136200.0 0.0 3673000.0 9463200.0 True False 0.0 3653212.8199665826 11441911.36710686 0.0 NCSSPEFSK(ub)TLQLEYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NCSSPEFSKTLQLEYR 16 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX45;Q5JX52;Q5JX61;Q5JX55;Q5JX54;E7EV27;Q5JX57 Q99829 CPNE1 Copine-1 1 46146000.0 10018000.0 11804000.0 24324000.0 True False 12968498.484302668 11147097.023450067 19897281.585316274 1.0 0.8595518623025432 1.5342779743854191 23.628508115686234 -6.852384779559159 1.2234636895741664 0.9248680881056182 1.5625274251620727 0.9437129467291686 0.06896261991600111 0.15485241584080497 0.44483969413566143 0.0440774147990037 0.10216951494172032 1.4048023350427926e-07 6.852384779559159 0.6376593370564545 NCTIVSPDAGGAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 NCTIVSPDAGGAKR 14 1 B1ALA9;P60891;A0A2R8Y7H4;P60891-2 B1ALA9 PRPS1 Ribose-phosphate pyrophosphokinase 1 1 4317500.0 1409500.0 1561400.0 1346600.0 True False 1847868.1496174156 1328445.206289529 1207266.749499306 1.0 0.718906923399579 0.6533294866028508 20.81743038956338 -13.999999999999998 0.20447471231516529 2.589879035264445 0.6125702294309766 0.9994876646942467 0.0034035429949295848 12.622989128989264 0.14336005683213268 8.041964532557948 0.04040495417530006 1.0000000000000041e-14 13.999999999999998 -1.9773088058334682 NCTIVSPDAGGAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 NCTIVSPDAGGAKR 14 1 B1ALA9;P60891;A0A2R8Y7H4;P60891-2 B1ALA9 PRPS1 Ribose-phosphate pyrophosphokinase 1 1 47754500.0 4042300.0 4457200.0 39255000.0 True False 6132464.631714896 3661777.8357374514 31496232.043922324 1.0 0.5971135678141635 5.135982665278682 22.548035577553172 -6.885250182945832 1.0500326525177832 0.7276372465091435 5.491942756879595 0.977681444854509 0.30644987715205096 0.12308331839926977 0.24501754257982244 0.22363756807238208 0.5488229002316497 1.3024162825849146e-07 6.885250182945832 4.764305510370452 up NCTIVSPDAGGAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NCTIVSPDAGGAKR 14 1 B1ALA9;P60891;A0A2R8Y7H4;P60891-2 B1ALA9 PRPS1 Ribose-phosphate pyrophosphokinase 1 1 3994580.0 1409500.0 820680.0 1764400.0 True False 1930630.240305273 784419.6439741593 1347685.0589586436 1.0 0.4063023709035688 0.6980544647148728 20.880640451086272 -10.504404530379391 6.330921280233762 1.0003262339203134 0.552178417809244 0.7585347373649799 0.11910729353771747 0.0005488360003863057 4.296379036028347e-05 0.11540653076574996 0.03844171369028482 3.130368535223429e-11 10.504404530379391 -0.44814781611106935 NCVAIAADRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NCVAIAADRR 10 1 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 4775200.0 1041400.0 2210700.0 1523100.0 False True 1365285.4849319444 1880872.1772411093 1365504.222606856 1.0 1.3776402063886772 1.0001602138727215 20.380771223495845 -10.196101879617117 13.534052696852804 1.00000001473129 1.1889002101527113 0.25031832225775863 0.15410556162895098 0.0 0.0 0.1492120684367169 0.04973735614557229 6.366461548036317e-11 10.196101879617117 0.18890019542142134 NCVAIAADRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NCVAIAADRR 10 1 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 13444500.0 1029300.0 11297000.0 1118200.0 False True 1561523.3519095932 9280962.086136136 897187.2798755303 1.0 5.94353076743067 0.5745589899621778 20.574522713727333 -6.664687511309578 1.956149463076751 4.169872543728681 0.5967719258380656 0.25557390426366045 2.102541228225578 0.47355987583544723 3.4881766421532707 0.8668835259825741 2.3323070571015325 2.164275228462049e-07 6.664687511309578 -3.5731006178906157 NCVAIAADRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NCVAIAADRR 10 1 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 4252200.0 1041400.0 1400900.0 1809900.0 False True 1426433.7227768076 1339003.6058432 1382438.8960605578 1.0 0.9387071999648121 0.9691574687181357 20.443981285018737 -10.069239956660587 4.121267203849623 1.0000064445409982 0.9539323343239854 0.7531929948555353 0.012431270219521407 3461340.1141185025 4228440.144660081 159.875500058206 0.004255554697250484 8.526288887982688e-11 10.069239956660587 -0.0460741102170128 NCVVELNFGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NCVVELNFGQK 11 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 65296000.0 22727000.0 18732000.0 23837000.0 False True 29795317.088581096 15937258.616764104 21370575.900649782 1.0 0.5348913914687613 0.7172461308975278 24.82858226523547 -10.129195803211227 5.2283421911791175 1.0000104695840073 0.6260687611828223 0.8486328249232485 0.07444601063090314 9.085484790999327e-06 1.5131439376319166e-06 0.07208405694774131 0.02402734661359349 7.426842205817062e-11 10.129195803211227 -0.373941708401185 NCVVELNFGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NCVVELNFGQK 11 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 18836200.0 12983000.0 3073300.0 2779900.0 False True 12570861.771534892 4300484.717047771 2051760.7947876158 1.0 0.3420994356000055 0.16321560383660932 23.583580218576454 -13.999999999999376 0.18275868377678545 4.443042627253444 0.02509373807016468 0.9994950698922394 0.008084716913541855 12.241671005195286 0.13554291852462125 14.977072222899878 0.13049441469370002 1.0000000000014357e-14 13.999999999999376 -4.417948889183279 NCVVELNFGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NCVVELNFGQK 11 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 86178000.0 17403000.0 47212000.0 21563000.0 False True 26401623.329721782 38786649.73096038 17301063.598601367 1.0 1.4691009430202755 0.6553030237017508 24.654123302042944 -6.750407969189241 1.6484769955197083 1.2757007140466015 0.6536485199897258 0.6506822941346833 0.19712249223367354 0.2993265540022883 1.6005393185841097 0.094460023054633 0.22921248065198793 1.7766097075847802e-07 6.750407969189241 -0.6220521940568756 NCVVELNFGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NCVVELNFGQK 11 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 68788000.0 22727000.0 18171000.0 27890000.0 False True 31129786.074081585 17368145.136538528 21302956.412580263 1.0 0.5579269030377022 0.6843271059391229 24.891792326758363 -10.470853392241013 9.114747843139158 1.0000056945020013 0.6211270044884165 0.922954087167261 0.05160266674879044 5.9714823575241395e-06 3.466743141003417e-07 0.04996481774937919 0.01665468907816306 3.3817897833001e-11 10.470853392241013 -0.37887869001358476 NCVVELNFGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NCVVELNFGQK 11 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 58614000.0 17403000.0 27033000.0 14178000.0 False True 22528526.564416 25528589.78608318 11597749.478564976 1.0 1.1331673073731243 0.5148028409848925 24.425249624135393 -6.85034797348993 1.2333904135434386 1.0710848657579402 0.489913809518714 0.9408136330913828 0.0646480915781558 0.1570739262792573 0.45964023153111844 0.0410107646038076 0.09492383032521315 1.4114062183511308e-07 6.85034797348993 -0.5811710562392262 NCWHLDAAMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NCWHLDAAMR 10 0 P41240 P41240 CSK Tyrosine-protein kinase CSK 0 10892900.0 2814800.0 3141000.0 4937100.0 False True 3690230.0585619737 2672375.0435221023 4426256.252007295 1.0 0.7241757291856991 1.1994526579007216 21.815279329783387 -6.749377854868714 1.6522694518528847 0.83769095398515 1.2003458115840742 0.6462486220909303 0.11589939137808895 0.3011270848313049 1.6172629363952604 0.055418076361200025 0.13462167074713863 1.7808286957117837e-07 6.749377854868714 0.36265485759892413 NCWHLDAAMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NCWHLDAAMR 10 0 P41240 P41240 CSK Tyrosine-protein kinase CSK 0 9465600.0 2814800.0 1624500.0 5026300.0 False True 3855507.6271098144 1552724.218496882 3839191.4598978884 1.0 0.4027288670314065 0.9957680884620226 21.878489391306278 -10.877168982963186 11.276995932778322 1.0123891911262206 0.6992484777567304 0.25535170863000745 0.24210724832706934 0.07116097337349951 0.0007750963226660677 0.22120195866051662 0.07813977839723694 1.326878072131684e-11 10.877168982963186 -0.31314071336949023 NCWQNYLDFHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NCWQNYLDFHR 11 0 P14854;A0A494C160 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 0 53032000.0 16522000.0 13483000.0 23027000.0 False True 21660501.999275614 11471388.956322351 20644386.930581115 1.0 0.5295994043307947 0.9530890341909675 24.36856334314453 -10.359288711545531 8.499075921559434 1.0000009274025903 0.7413442192608811 0.33217156903770817 0.17288891741958967 3.038221286590827e-06 2.2892800335364296e-07 0.16739957558356588 0.05579965815915834 4.372313446010018e-11 10.359288711545531 -0.25865670814170916 NCWQNYLDFHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NCWQNYLDFHR 11 0 P14854;A0A494C160 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 0 16864100.0 11422000.0 1863300.0 3578800.0 False True 11059414.862086698 2607325.4069811343 2641404.918301345 1.0 0.23575618054798084 0.23883767371422782 23.39877172086034 -10.519656257020705 9.341945238072675 1.0000248319344853 0.23729692713117798 0.9999877573194019 0.0012580143171964057 6.506534107767844e-07 3.3455295833118885e-08 0.0012181064359529767 0.0004060223749826803 3.022342950719402e-11 10.519656257020705 -0.7627279048033073 NCWQNYLDFHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NCWQNYLDFHR 11 0 P14854;A0A494C160 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 0 31448400.0 7929400.0 17672000.0 5847000.0 False True 12029479.51678998 14518293.528033776 4691337.887168864 1.0 1.2068929090215472 0.3899867721309965 23.520070886543447 -6.839574110039556 1.2843932620690621 1.1100679168876193 0.36334726896145275 0.9237173661883673 0.09577599573090258 0.16929565155971377 0.5426945308055837 0.05847645111173324 0.1347017812718136 1.4468579334298166e-07 6.839574110039556 -0.7467206479261665 down NCWQNYLDFHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NCWQNYLDFHR 11 0 P14854;A0A494C160 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 0 52315000.0 16522000.0 16511000.0 19282000.0 False True 22630629.890261628 15781489.425424457 14727988.725255359 1.0 0.6973508692400788 0.650798886141171 24.43177340466742 -13.999999999878549 0.26354135500888254 3.257049399537645 0.6343528512436899 0.9995696404907363 0.003211617776440154 14.576604259347638 0.16246687499423723 17.55872839737699 0.019979218888879522 1.000000000279652e-14 13.999999999878549 -2.622696548293955 NCWQNYLDFHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NCWQNYLDFHR 11 0 P14854;A0A494C160 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 0 21986300.0 11422000.0 1591300.0 8973000.0 False True 9497899.0803953 1582727.3510516821 10849212.813535573 1.0 0.16663973134001855 1.1422750148956133 23.179176996294615 -6.680539193707847 1.9001490233346834 0.47296614801502684 1.1385587595682285 0.32647838699636955 0.35315848503909725 0.43734804560048385 3.053499907591262 0.14911507001288687 0.3929839794303183 2.086703796977316e-07 6.680539193707847 0.6655926115532016 NCWQNYLDFHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NCWQNYLDFHR 11 0 P14854;A0A494C160 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 0 30840200.0 7929400.0 13873000.0 9037800.0 False True 10264764.611841654 13100955.354652897 7393013.1356590865 1.0 1.276303534475535 0.7202321159055461 23.291197208635896 -6.771617283802286 1.5684639676804244 1.1581522409363667 0.7169253064547263 0.7366533826537653 0.1164988475979614 0.26381334216933633 1.2810807881563397 0.05854070731585819 0.1391340206825386 1.691931266654593e-07 6.771617283802286 -0.4412269344816404 NDEELNK(ub)LLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NDEELNKLLGK 11 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q9BTM1-2;Q16777 A0A0U1RR32;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 2-C 1 484190000.0 174520000.0 170660000.0 139010000.0 True False 228797410.05408415 145198193.22746968 124626578.6780771 1.0 0.6346146715259893 0.5447027509997483 27.769495480256822 -13.999999999999979 0.19692424566438502 3.0078274281514688 0.48450781643897317 0.9994870650513126 0.0044591430825858475 12.471747754337558 0.1407198998609468 9.633021708058418 0.05859248134112997 1.000000000000049e-14 13.999999999999979 -2.5233196117124956 NDEELNK(ub)LLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDEELNKLLGK 11 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q9BTM1-2;Q16777 A0A0U1RR32;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 2-C 1 633790000.0 205500000.0 191930000.0 236360000.0 True False 198976514.98501292 268568649.90172756 174450225.35199124 1.0 1.3497504965445615 0.8767377665908511 27.56802291994776 -6.708612755726439 1.7999533633816331 1.2153186135575686 0.8778837624164444 0.45861661170026224 0.14741482638721284 0.37786243589634955 2.385476818570894 0.0651933407066394 0.16591311966812752 1.956082844887974e-07 6.708612755726439 -0.33743485114112426 NDEELNK(ub)LLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NDEELNKLLGK 11 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q9BTM1-2;Q16777 A0A0U1RR32;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 2-C 1 1204620000.0 462610000.0 321400000.0 420610000.0 True False 701813191.3211857 264043658.89033857 337476249.14008784 1.0 0.37623068667784365 0.48086335981342565 29.38651182407295 -10.086084636497857 5.4164537236176304 1.000006409144016 0.4285470232463979 0.9754726839904889 0.04271610993543698 3.3060845596370187e-06 5.577832390754329e-07 0.041360159408441496 0.013786565199389844 8.201916875516697e-11 10.086084636497857 -0.571459385897618 NDEELNK(ub)LLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NDEELNKLLGK 11 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q9BTM1-2;Q16777 A0A0U1RR32;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 2-C 1 564950000.0 174520000.0 225660000.0 164770000.0 True False 239044760.2256662 215689595.04217064 125854719.54466994 1.0 0.9022979413501995 0.5264901829509205 27.832705541779713 -6.945774521918106 0.6034545153154752 1.0042028452158398 0.40523309128156776 0.9988265714104123 0.006992235168653218 0.0852281818456186 0.04333586224778468 0.0071522000577805955 0.03161797205978348 1.1329884382992806e-07 6.945774521918106 -0.598969753934272 NDEELNK(ub)LLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDEELNKLLGK 11 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q9BTM1-2;Q16777 A0A0U1RR32;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 2-C 1 516852000.0 205500000.0 232520000.0 78832000.0 True False 170882355.1935944 231267368.60839352 95315406.72201462 1.0 1.3533718466508045 0.5577837841363481 27.348428195382038 -6.785962386322541 1.5123362694527367 1.1985477087848388 0.5502304003215679 0.7879731400045794 0.14986797745717145 0.24144247526904805 1.0909370317491787 0.07801814074690819 0.18321820504394926 1.6369582901065388e-07 6.785962386322541 -0.648317308463271 NDEELNK(ub)LLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NDEELNKLLGK 11 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q9BTM1-2;Q16777 A0A0U1RR32;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 2-C 1 1247110000.0 462610000.0 336290000.0 448210000.0 True False 598857764.4063946 317575165.8773315 366640379.0229657 1.0 0.5303014918611288 0.6122328219062008 29.1576381461654 -10.793557921389127 7.163216970185051 1.0142363072712137 0.5712671568836648 0.9733404657560972 0.033448325426331145 0.0074467305082662584 0.00021461259800824778 0.031713483645473314 0.010795400611225548 1.6085778292826986e-11 10.793557921389127 -0.4429691503875489 NDEELNK(ub)LLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NDEELNKLLGR 11 1 Q93077;Q7L7L0;P04908 Q93077 HIST1H2AC;HIST3H2A;HIST1H2AB Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E 1 295076000.0 51194000.0 138377000.0 105505000.0 True False 67115829.76340128 117731690.9893212 94588354.67542276 1.0 1.7541568271502037 1.4093300344921373 26.000149741035607 -10.121794370517513 4.585572451849068 0.9999453425158293 1.5817434308341451 0.7914448374904703 0.14077494865305698 98202981.44950445 5.761564582629258 56674.77040345057 0.0481910093114513 7.554498329187043e-11 10.121794370517513 0.5817980883183158 NDEELNK(ub)LLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDEELNKLLGR 11 1 Q93077;Q7L7L0;P04908 Q93077 HIST1H2AC;HIST3H2A;HIST1H2AB Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E 1 553455000.0 170723000.0 228150000.0 154582000.0 True False 165303491.81404567 319251484.7865323 114092336.83940391 1.0 1.9313051483852914 0.6901991941449697 27.300541959044313 -6.70589914423601 1.809843777803334 1.5749257559291492 0.6934542524173919 0.44562033529374456 0.39270748814003936 0.3833671575814253 2.445190001852139 0.17284546807531012 0.44130274868290065 1.968343342998567e-07 6.70589914423601 -0.8814715035117573 NDEELNK(ub)LLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NDEELNKLLGR 11 1 Q93077;Q7L7L0;P04908 Q93077 HIST1H2AC;HIST3H2A;HIST1H2AB Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E 1 935530000.0 286190000.0 251590000.0 397750000.0 True False 434171153.2915629 206691798.81835803 319134538.15998214 1.0 0.4760606439450767 0.7350431638319159 28.693688634324843 -10.222796843915313 4.803453158527157 1.0000729001254702 0.6055519038875234 0.755679426381158 0.10572917100721313 8.255834216567794e-05 1.3358025064800153e-05 0.10239068084819036 0.0341239432094562 5.986915880159509e-11 10.222796843915313 -0.3945209962379468 NDEELNK(ub)LLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NDEELNKLLGR 11 1 Q93077;Q7L7L0;P04908 Q93077 HIST1H2AC;HIST3H2A;HIST1H2AB Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E 1 350513000.0 51194000.0 197931000.0 101388000.0 True False 70121805.26583065 189185753.9497114 77442242.55140504 1.0 2.697958976277225 1.1043960185825612 26.063359802558498 -6.631229758987391 2.0763174164885636 2.117650911521975 1.1108754277930488 0.12185705765631294 0.7281107388164236 0.5557791120833001 4.567774151696552 0.28667822478517985 0.8063759949828945 2.3376002283394814e-07 6.631229758987391 -1.0067754837289262 NDEELNK(ub)LLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDEELNKLLGR 11 1 Q93077;Q7L7L0;P04908 Q93077 HIST1H2AC;HIST3H2A;HIST1H2AB Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E 1 454362000.0 170723000.0 201260000.0 82379000.0 True False 141963738.81127027 200175772.43301776 99604068.02253948 1.0 1.410048608955952 0.7016162638189977 27.08094723447859 -6.749803111195648 1.650852567696236 1.2411763692886677 0.700254445944747 0.6479884530197506 0.17230272097981458 0.3003995088314241 1.610747940254983 0.08245621531709357 0.20020088047672396 1.7790857815177204e-07 6.749803111195648 -0.5409219233439208 NDEELNK(ub)LLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NDEELNKLLGR 11 1 Q93077;Q7L7L0;P04908 Q93077 HIST1H2AC;HIST3H2A;HIST1H2AB Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E 1 888330000.0 286190000.0 234250000.0 367890000.0 True False 370478596.648291 221213781.5777009 300937794.87017 1.0 0.5971027303034926 0.8122946847476357 28.464814956417293 -10.047000364809916 5.024189011427422 1.0000048107750814 0.70469870752376 0.7151670974625378 0.08785174752966042 4.734160837340428e-06 8.97908992803698e-07 0.08506347392452189 0.02835402959223623 8.974280406556055e-11 10.047000364809916 -0.29530610325132145 NDEELNKLLGGVTIAQGGVLPNIQAVLLPKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NDEELNKLLGGVTIAQGGVLPNIQAVLLPKK 31 2 Q8IUE6;P16104;Q96QV6 Q8IUE6;P16104 HIST2H2AB;H2AFX;HIST1H2AA Histone H2A type 2-B;Histone H2AX;Histone H2A type 1-A 1 148608000.0 72317000.0 42554000.0 33737000.0 True False 93615782.08118546 40185832.49202767 27597212.170852456 1.0 0.4292634382649041 0.29479230485859326 26.480248429179795 -13.999999999999982 0.2030771164215943 4.210470923031971 0.2100614867560217 0.9994873202475306 0.00692206982317096 12.59342428645097 0.14287649029716307 16.080524357727114 0.08370048189337365 1.0000000000000409e-14 13.999999999999982 -4.000409436275949 NDEELNKLLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDEELNKLLGR 11 1 Q93077;Q7L7L0;P04908 Q93077 HIST1H2AC;HIST3H2A;HIST1H2AB Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E 0 4315400.0 1810100.0 1492100.0 1013200.0 False True 1752639.3662986446 2087903.3111987049 747812.5246515375 1.0 1.1912908903832828 0.42667792304062196 20.741097738281127 -6.840440090117001 1.2802035402846448 1.1017647062381661 0.4012877910618683 0.9252220116080362 0.08884028152239803 0.16829361996788889 0.5355699133484377 0.054408132372093757 0.12537116898335593 1.4439757835511462e-07 6.840440090117001 -0.7004769151762978 down NDETK(ub)ALTPASLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NDETKALTPASLQK 14 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5GY68;Q9UJX4-2 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 2898120.0 1072500.0 834820.0 990800.0 True False 1406057.8861047747 710268.1101028734 888281.5204247086 1.0 0.5051485554912258 0.631753165501265 20.423224559379868 -10.172711905256394 7.922944928991018 1.0000001203572442 0.5684508604962742 0.9393635847019972 0.05168611560144258 1.0988660818506492e-07 1.1482939413297681e-08 0.050044879661472065 0.016681622079544867 6.718744015209835e-11 10.172711905256394 -0.4315492598609699 NDETK(ub)ALTPASLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NDETKALTPASLQK 14 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5GY68;Q9UJX4-2 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 25862800.0 3903600.0 5136200.0 16823000.0 True False 5922046.591386655 4219604.980686231 13497926.676217163 1.0 0.7125247860804493 2.2792672208707843 22.49766441021081 -6.859371236974842 1.1890574829136336 0.8442981769278246 2.3541721358495873 0.952852042302024 0.14786947367036493 0.14745523480819886 0.39653400486692164 0.09702290188228797 0.22630025158905562 1.3823842052305707e-07 6.859371236974842 1.5098739589217627 up NDETK(ub)ALTPASLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NDETKALTPASLQK 14 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5GY68;Q9UJX4-2 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 3027460.0 1072500.0 624360.0 1330600.0 True False 1469032.2332227083 596773.7107175828 1016339.6845672025 1.0 0.40623595399837 0.6918430117340545 20.48643462090276 -10.481859363866214 6.258744546586223 1.0002577677846465 0.5490394828662337 0.7687395688114542 0.11659859306500707 0.00041961697636378744 3.4738809722910696e-05 0.11295906561336862 0.03763203409433231 3.297164658752814e-11 10.481859363866214 -0.45121828491841276 NDETK(ub)ALTPASLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NDETKALTPASLQK 14 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5GY68;Q9UJX4-2 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 20792200.0 3903600.0 3822600.0 13066000.0 True False 5053287.151459766 3609868.949664542 10688122.068481453 1.0 0.7143605422505513 2.1150830633865576 22.26879073230326 -6.853585736543179 1.21758263652747 0.8469591965233655 2.1750977141929564 0.9453671322208979 0.14125608421872698 0.15356221095428926 0.43627758969506875 0.0906862862137199 0.21040274716247265 1.40092299346502e-07 6.853585736543179 1.3281385176695908 up NDFGNFFGSAVTK(ub)PSSSVTPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDFGNFFGSAVTKPSSSVTPR 21 1 Q8IWR0;I3L2K5;I3L323 Q8IWR0 ZC3H7A Zinc finger CCCH domain-containing protein 7A 1 9816100.0 3999000.0 2651200.0 3165900.0 True False 3325345.6857381193 2636917.459378004 3827875.0525322943 1.0 0.7929754403240917 1.1511209402828235 21.665072892848396 -6.7499462578958624 1.6498341506743095 0.8782629159478004 1.1518396118784509 0.648853737071669 0.08699300846818862 0.30012455259544485 1.6072476178281898 0.04165179412126048 0.10113331567629795 1.778499478205947e-07 6.7499462578958624 0.2735766959306505 NDFTEEEEAQVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NDFTEEEEAQVR 12 0 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 0 17049000.0 1636000.0 7247200.0 8165800.0 False True 2144811.8430465343 6165946.009364336 7320881.347884621 1.0 2.8748190799833058 3.4132977079639266 21.032419659934707 -9.774520587796198 0.330162135139139 1.3556867905050139e-12 3.561123062021205 0.9987025075503306 0.03725801905534833 1.135244602719334 0.1417170605669138 1.3352317552455824 0.16968204422904448 1.680658251959336e-10 9.774520587796198 3.561123062019849 NDFTEEEEAQVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDFTEEEEAQVR 12 0 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 0 12289000.0 4333700.0 0.0 7955300.0 False True 4196129.065647447 0.0 5871568.276115658 1.0 0.0 1.39928209648854 22.000627622717396 -6.714850957020551 1.7779044719638852 0.38828646875956213 1.3964869128107187 0.4880828295724443 0.42109105291078963 0.3654214519761091 2.2544750155438 0.18827314678864052 0.4755114564307541 1.9281865226962441e-07 6.714850957020551 1.0082004440511565 NDFTEEEEAQVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NDFTEEEEAQVR 12 0 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 0 13169900.0 1636000.0 5700100.0 5833800.0 False True 2240873.41123762 5448250.734289977 4455976.590882417 1.0 2.431306787330277 1.9884999163881416 21.0956297214576 -10.557606655070984 5.624506053268372 0.9960689873511009 2.2099033518588214 0.9087117751587095 0.1807751480677816 0.008916807403135201 0.0007013473523871429 0.17514681642642047 0.05834492815622451 2.7694488278183515e-11 10.557606655070984 1.2138343645077203 NDFTEEEEAQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDFTEEEEAQVR 12 0 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 0 6672380.0 4333700.0 1549400.0 789280.0 False True 3603663.565462189 1541053.074668178 954314.798781606 1.0 0.42763511262198806 0.26481795024592153 21.781032898151672 -13.999999999999996 0.17632205803159826 3.9373223035648186 0.13045138962682676 0.9995030382681855 0.007028382727264919 12.159387933091791 0.1330743984200474 12.226779152464823 0.12547469056582183 1.0000000000000082e-14 13.999999999999996 -3.806870913937992 NDGEEK(ub)K(ub)GPGGGAPVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NDGEEKKGPGGGAPVR 16 2 Q8N5D0-5;Q8N5D0-3;Q8N5D0-6;Q8N5D0-2;Q8N5D0-4;Q8N5D0 Q8N5D0-5 WDTC1 WD and tetratricopeptide repeats protein 1 2 1793380.0 724740.0 752350.0 316290.0 True False 950141.1583921438 640102.3126373312 283563.344867916 1.0 0.6736918056686764 0.2984433863993115 19.857782338810907 -7.245804775301367 0.3188398748795651 1.0630141018574668 1.1360647501827748e-15 0.9998630294569539 0.003354686947609765 0.09629228056667412 0.01992827609180256 0.010836385604694167 0.044703618993520405 5.6779978625036076e-08 7.245804775301367 -1.0630141018574657 down NDGEEK(ub)K(ub)GPGGGAPVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NDGEEKKGPGGGAPVR 16 2 Q8N5D0-5;Q8N5D0-3;Q8N5D0-6;Q8N5D0-2;Q8N5D0-4;Q8N5D0 Q8N5D0-5 WDTC1 WD and tetratricopeptide repeats protein 1 2 1767210.0 724740.0 686970.0 355500.0 True False 992695.9633620749 656617.3938939995 271538.22175232245 1.0 0.6614486389872682 0.27353613973877106 19.920992400333798 -7.3219151579871244 0.3340356010884367 1.0583049917679528 5.262178235863876e-15 0.9997520585542005 0.004673546213610836 0.10633458640905999 0.025667328208188716 0.013224326607908019 0.05170188900900486 4.7652406952724507e-08 7.3219151579871244 -1.0583049917679475 down NDGEEK(ub)K(ub)GPGGGAPVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDGEEKKGPGGGAPVR 16 2 Q8N5D0-5;Q8N5D0-3;Q8N5D0-6;Q8N5D0-2;Q8N5D0-4;Q8N5D0 Q8N5D0-5 WDTC1 WD and tetratricopeptide repeats protein 1 2 1910310.0 854100.0 859390.0 196820.0 True False 710221.9930454933 854760.2954944418 237974.15200714063 1.0 1.203511442709843 0.33507009686744127 19.437910510614326 -6.84495033685813 1.2591645724976515 1.1082985347475625 0.30358255844711857 0.9326400164602617 0.09624856827911442 0.16309644883294463 0.5001524173628257 0.05988236118492244 0.13820022135566454 1.4290573670367677e-07 6.84495033685813 -0.8047159763004439 down NDGVLLLQALTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NDGVLLLQALTR 12 0 O60763;O60763-2 O60763 USO1 General vesicular transport factor p115 0 13849700.0 2948400.0 3469900.0 7431400.0 False True 4038503.1575140576 3316588.344575145 5676256.374487234 1.0 0.8212419837791349 1.4055347125149489 21.945389236711808 -6.82457852483744 1.351814193024101 0.9040695572304486 1.4196023665551691 0.8946232939830854 0.07935345182828044 0.18759383832097737 0.6722930781169574 0.04611216238357021 0.10618110398509607 1.4976884313367912e-07 6.82457852483744 0.5155328093247206 NDK(ub)SEEEQSSSSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NDKSEEEQSSSSVK 14 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910;G3V2Q1 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 172707500.0 73429000.0 64100000.0 35178500.0 True False 96266130.08744751 54536529.85984306 31538566.275999855 1.0 0.5665183570826254 0.32761851180005297 26.52052495916582 -9.397439549859003 0.16479845316562597 1.5438027923732132 3.02732923081892e-09 0.9997284909604698 0.004585753623788458 0.8302086969586387 0.06265813177106963 0.38796382774160276 0.1703015563793975 4.0046120528470866e-10 9.397439549859003 -1.5438027893458839 NDK(ub)SEEEQSSSSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDKSEEEQSSSSVK 14 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910;G3V2Q1 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 147911100.0 61559000.0 60253000.0 26099100.0 True False 59604843.240693 84312337.11524402 19262962.753783002 1.0 1.4145215813214804 0.3231778108365517 25.828926227037257 -6.80376580192888 1.4404340826611928 1.2276230943871993 0.30666219547690804 0.8429810164552718 0.17823933586951876 0.21541168367595953 0.8819396762974341 0.09732814135949952 0.22585599685121915 1.57120986810364e-07 6.80376580192888 -0.9209608989102913 down NDK(ub)SEEEQSSSSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NDKSEEEQSSSSVK 14 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910;G3V2Q1 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 79956500.0 31735700.0 25462600.0 22758200.0 True False 48145377.090447135 20918600.08979817 18260031.794726588 1.0 0.43448823862153896 0.37926864214653105 25.52089394163903 -13.999999999999998 0.32893960804812034 7.116798205723023 0.36936746577650265 0.999712636546215 0.004755103150245188 18.734121194131493 0.18334477459121054 79.23465138676669 0.017765670894686437 1.0000000000000041e-14 13.999999999999998 -6.7474307399465205 NDK(ub)SEEEQSSSSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NDKSEEEQSSSSVK 14 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910;G3V2Q1 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 172541000.0 73429000.0 57635000.0 41477000.0 True False 100577685.64411208 55088495.12654215 31680986.845628902 1.0 0.5477208465650063 0.31499021520270526 26.58373502068871 -9.92189389231328 0.1591252731480542 1.673056865583043 4.7790359890251174e-21 0.9996959867709008 0.004958815710607037 1.4443517564263195 0.07160745555375975 0.5988380562450044 0.18475645145084427 1.197032957042201e-10 9.92189389231328 -1.673056865583043 NDK(ub)SEEEQSSSSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDKSEEEQSSSSVK 14 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910;G3V2Q1 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 127061900.0 61559000.0 53440000.0 12062900.0 True False 51189036.02609479 53152108.11299048 14585196.617452178 1.0 1.0383494638557946 0.2849281359785138 25.609331502471534 -6.894912194636548 0.9928938001300432 1.0358452393846667 0.2135360852903252 0.9838598754009525 0.044018267190535816 0.11524710799174424 0.19930100143046947 0.03354322342802134 0.08524444786461792 1.2737605830347477e-07 6.894912194636548 -0.8223091540943415 down NDK(ub)SEEEQSSSSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NDKSEEEQSSSSVK 14 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910;G3V2Q1 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 71423900.0 31735700.0 27818300.0 11869900.0 True False 41082489.25417093 26270187.150748983 9709699.995459037 1.0 0.6394497419136277 0.23634643790415527 25.29202026373148 -7.442978282095799 0.35515879952089907 1.0533540464579165 3.77830053047262e-12 0.9994720361868269 0.007167163783339588 0.1176018039275416 0.03609761267676741 0.017595891302894056 0.061715567310616 3.6059667504498034e-08 7.442978282095799 -1.0533540464541382 down NDKSEEEQSSSSVK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 NDKSEEEQSSSSVKK 15 2 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910;G3V2Q1 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 69831000.0 29404000.0 27024000.0 13403000.0 True False 38548928.748741016 22992124.53872698 12016186.13065439 1.0 0.5964400382845371 0.3117125824423028 25.20018743329211 -8.084715817978772 0.21929967991021884 1.2288476693775228 3.1666194710681858e-15 0.9997401795352091 0.004551740038592215 0.09290433951409965 0.041959480280825745 0.083915077017841 0.10439293014653078 8.227808631983702e-09 8.084715817978772 -1.2288476693775197 down NDKSEEEQSSSSVK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDKSEEEQSSSSVKK 15 2 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910;G3V2Q1 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 67216700.0 25652000.0 32578000.0 8986700.0 True False 24837691.301194917 45586565.292025656 6632813.674778898 1.0 1.8353785277069021 0.2670463045194462 24.566027743441786 -6.761995650563017 1.6047089233174878 1.4840451661622287 0.26070251579401177 0.6990829995795967 0.351474891136674 0.27961616047403376 1.4195137981195058 0.1727671121670357 0.4144139770565856 1.7298336833240513e-07 6.761995650563017 -1.223342650368217 NDKSEEEQSSSSVK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 NDKSEEEQSSSSVKK 15 2 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910;G3V2Q1 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 2221970.0 962660.0 743160.0 516150.0 True False 1460425.59987301 610537.2916644171 414132.72626341827 1.0 0.4180543614940096 0.2835698896947772 20.477957432504418 -13.999999999999998 0.20581526095518715 4.309060928918257 0.20106897001535246 0.9994880932621537 0.007034583129763495 12.65195637800077 0.1438211805871735 16.896623442586648 0.0820633008368061 1.0000000000000041e-14 13.999999999999998 -4.107991958902904 NDKSEEEQSSSSVK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NDKSEEEQSSSSVKK 15 2 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910;G3V2Q1 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 61681000.0 29404000.0 19738000.0 12539000.0 True False 40275453.41322187 18865909.895162452 9577546.448811186 1.0 0.46842203616183337 0.23780108321926452 25.263397494815003 -10.616397868612822 0.1763557188136697 1.8550604401331665 6.083225292333415e-20 0.999526674635121 0.006943430241786914 2.4560934162718353 0.0931935867105356 1.0650537991730589 0.16706623159368256 2.4188120939236602e-11 10.616397868612822 -1.8550604401331665 NDKSEEEQSSSSVK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDKSEEEQSSSSVKK 15 2 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910;G3V2Q1 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 53119200.0 25652000.0 21296000.0 6171200.0 True False 21330774.576282658 21181274.221074954 7461569.387595093 1.0 0.9929913302176129 0.3498030210253823 24.346433018876063 -6.909281165506015 0.9006096282569375 1.0203703146426077 0.2679455128724065 0.9906475104727102 0.029483185116301873 0.10489576509942529 0.14135783839496352 0.024052748903570984 0.06607094192994666 1.2323067702719677e-07 6.909281165506015 -0.7524248017702013 down NDLAVVDVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NDLAVVDVR 9 0 P19338 P19338 NCL Nucleolin 0 88210000.0 19204000.0 40409000.0 28597000.0 False True 25176629.971800543 34380134.71304827 25638056.761793915 1.0 1.3655574535414887 1.0183275835769203 24.585581847651554 -10.58992939738306 6.283741805540103 0.9994913899448036 1.1919425185585415 0.28948222678249247 0.14175600081102463 0.0010127001022899311 6.608775217687892e-05 0.13761093202244348 0.045751552530505266 2.5708136822089818e-11 10.58992939738306 0.19245112861373792 NDLAVVDVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDLAVVDVR 9 0 P19338 P19338 NCL Nucleolin 0 65391000.0 23660000.0 10574000.0 31157000.0 False True 22908926.250829216 14796253.342681546 22996047.010035492 1.0 0.6458728436539437 1.0038029176161463 24.449406504831142 -10.970682618028746 10.70195478311494 1.0850524610277388 0.8248378816990335 0.24203234617192937 0.14612434080067327 0.0821710468947542 0.00022510264427738966 0.03920602663992047 0.04716142819971202 1.069836428997954e-11 10.970682618028746 -0.2602145793287053 NDLAVVDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NDLAVVDVR 9 0 P19338 P19338 NCL Nucleolin 0 66480000.0 19204000.0 47276000.0 0.0 False True 26304237.768586367 45187189.999174275 0.0 1.0 1.717867303235022 0.0 24.648791909174445 -6.805191819401869 1.5140489228324745 1.3988274934321443 7.444353862740672e-22 0.8110590279254531 0.3062109381443086 0.223241721182369 1.022122750337041 0.16099536736016462 0.3605463696797222 1.56605921951921e-07 6.805191819401869 -1.3988274934321443 NDLEK(ub)GDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDLEKGDVK 9 1 P53618;E9PP73;E9PP63;E9PKQ1 P53618 COPB1 Coatomer subunit beta 1 16570900.0 5623000.0 8743500.0 2204400.0 True False 4675773.641136653 8696397.030051135 2665329.8480060003 1.0 1.8598840956588933 0.5700297004450529 22.156773658579073 -6.727004966997998 1.7340798737858474 1.519187708776446 0.5711957027773527 0.545371070409244 0.36156748747507356 0.34187483464146357 2.0125714812139104 0.16532643195542285 0.411655795647919 1.8749730639987057e-07 6.727004966997998 -0.9479920059990934 NDLMEYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDLMEYAK 8 0 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 0 4686070.0 1486000.0 519170.0 2680900.0 False True 1438827.7433952764 726477.2884357844 1978691.8647239532 1.0 0.504909146887506 1.375211086807884 20.45646245214259 -6.752406899084121 1.6410193345629818 0.7097209142147779 1.3772532178637438 0.6592058101712811 0.2080699937847318 0.29587790368684114 1.5683922272426591 0.10013229760144836 0.24247518929967807 1.7684512849221207e-07 6.752406899084121 0.6675323036489659 NDLMEYAK(ub)QHGIPIPVTPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDLMEYAKQHGIPIPVTPK 19 1 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 1 11554600.0 3582400.0 3300700.0 4671500.0 True False 3468678.6729066214 4618686.722923108 3447894.0080040097 1.0 1.3315406696501015 0.9940079013184594 21.725954769569228 -6.650279769503328 2.0074496117538043 1.2150923125525692 0.9954257791635176 0.19515937941209915 0.14149618268751282 0.507889977692507 3.9234053030866547 0.05715666362485384 0.15673527787468144 2.2372794343030966e-07 6.650279769503328 -0.21966653338905162 NDLMEYAK(ub)QHGIPIPVTPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDLMEYAKQHGIPIPVTPK 19 1 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 1 16521700.0 3582400.0 6373800.0 6565500.0 True False 2978924.3272288707 6339463.074299758 7938315.694557886 1.0 2.1281047713612153 2.664826233415088 21.506360045003504 -9.473938109048012 0.21316421970263272 4.832306267118972e-19 3.1267485369231904 0.9993854411155202 0.017199727723514382 0.8970909873966264 0.08442719569557273 0.8714198263037823 0.28580727989329346 3.3578546334559746e-10 9.473938109048012 3.1267485369231904 NDPFTSDPFTK(ub)NPSLPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NDPFTSDPFTKNPSLPSK 18 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 151456100.0 41046500.0 65267100.0 45142500.0 True False 53812358.99487145 55529503.08916314 40471587.13743687 1.0 1.0319098461090572 0.7520872136695212 25.681434216415955 -6.87854039795879 1.087945392176479 1.0194185083788334 0.7328061217517863 0.9724872075140865 0.02074512580659142 0.12892906346260866 0.2801868964501845 0.014707786717135062 0.035437896982399734 1.322694665576492e-07 6.87854039795879 -0.28661238662704713 NDPFTSDPFTK(ub)NPSLPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDPFTSDPFTKNPSLPSK 18 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 243853100.0 82814900.0 78820100.0 82218100.0 True False 80185986.33008444 110293376.97139147 60682713.11987032 1.0 1.37546948063182 0.7567745425001173 26.256846790933675 -6.74242420123175 1.6775963611022235 1.2227800284989812 0.7562039859424514 0.6157761462351224 0.15775210181287258 0.3134956095119943 1.7332206856235637 0.07435907807985866 0.1820030345329279 1.809571712879776e-07 6.74242420123175 -0.46657604255652974 NDPFTSDPFTK(ub)NPSLPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NDPFTSDPFTKNPSLPSK 18 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 290314300.0 118779600.0 99446800.0 72087900.0 True False 180197337.1519293 81699741.55860513 57839694.96775101 1.0 0.45339039327602193 0.32097974299689447 27.425002451126648 -13.99999999999999 0.1991485499594839 4.028742769462151 0.23426119988737182 0.9994869135371429 0.006657197206718982 12.514161778420513 0.14150504211832157 14.758456944444307 0.08485040793254939 1.0000000000000246e-14 13.99999999999999 -3.7944815695747796 NDPFTSDPFTK(ub)NPSLPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NDPFTSDPFTKNPSLPSK 18 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 153188000.0 41046500.0 53021700.0 59119800.0 True False 56222500.28995421 50679025.97468518 45156920.850500576 1.0 0.9014011421285094 0.8031823668035835 25.744644277938846 -6.971172981502187 0.2284395752608883 1.0407330516833864 0.6610492929048232 0.9999901370437377 0.00025227749148075315 0.07592392318517953 0.007654283368993376 0.0025529704781862674 0.009784876656708076 1.0686291545060476e-07 6.971172981502187 -0.3796837587785632 NDPFTSDPFTK(ub)NPSLPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDPFTSDPFTKNPSLPSK 18 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 290236100.0 82814900.0 146539000.0 60882200.0 True False 68864258.67212655 145749565.32128587 73612386.53251263 1.0 2.1164762117780462 1.068949088423251 26.03725206636795 -6.631129230792742 2.076030508848444 1.7349494869399082 1.073161015219689 0.1215926615726215 0.47877335597620435 0.5561503280918437 4.569166431278105 0.18851003116944 0.530441896557283 2.3381413863332603e-07 6.631129230792742 -0.6617884717202192 NDPFTSDPFTK(ub)NPSLPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NDPFTSDPFTKNPSLPSK 18 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 297377600.0 118779600.0 127177000.0 51421000.0 True False 153762533.69595528 120099488.15243205 42062905.62401534 1.0 0.7810712093877995 0.2735575735711345 27.196128773219097 -6.957058753485825 0.47507427418588183 1.0127647019753245 0.020879762738691205 0.999645081318475 0.005732214166518613 0.08076900526085835 0.025144020033604334 0.007085862075972557 0.0418746660888516 1.1039292648386715e-07 6.957058753485825 -0.9918849392366333 down NDPFTSDPFTK(ub)NPSLPSKLDPFESSDPFSSSSVSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSK 36 2 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 15301600.0 5356200.0 5648900.0 4296500.0 True False 4453917.619892608 5618468.254481147 5194878.285228535 1.0 1.261466586042653 1.1663615559539227 22.086643443464354 -10.187601102187601 4.3992035202166395 0.9999437800518408 1.2139140710027287 0.8708918213345528 0.03882646597204222 2.173444508176496e-05 4.013682182809956e-06 0.03760357896748646 0.012531188005123704 6.492304754716024e-11 10.187601102187601 0.21397029095088793 NDPFTSDPFTK(ub)NPSLPSKLDPFESSDPFSSSSVSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NDPFTSDPFTKNPSLPSKLDPFESSDPFSSSSVSSK 36 2 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 100654000.0 27166000.0 43047000.0 30441000.0 True False 35166922.52191719 40651396.60864583 24901050.351036545 1.0 1.1559554744464926 0.7080815881889406 25.06771575360665 -6.812642521927379 1.4033394796856542 1.0847333014748708 0.6997593375297552 0.8666262425616598 0.0677930959565576 0.20322060398890723 0.788263333275249 0.03797917469327394 0.08775556521430246 1.539421253030597e-07 6.812642521927379 -0.3849739639451156 NDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACK ddPTM_RPMI8226_Bortezomib_8h_R1 2 NDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACK 41 0 P68104;A0A087WVQ9;A0A087WV01 P68104 EEF1A1 Elongation factor 1-alpha 1;Elongation factor 1-alpha 0 4149016100.0 951897000.0 1739958100.0 1457161000.0 False True 1444097341.99231 1429448982.7003162 1169152489.6536448 1.0 0.9898563906559203 0.8096078121995952 30.42752084695673 -6.918490637783958 0.8358544644020577 1.0041975213829488 0.781527696548619 0.9937510837887044 0.006913636020616229 0.09906789966360348 0.11027934863243088 0.005909681190283715 0.017454506753506797 1.206450095722231e-07 6.918490637783958 -0.22266982483432984 NDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACK 41 0 P68104;A0A087WVQ9;A0A087WV01 P68104 EEF1A1 Elongation factor 1-alpha 1;Elongation factor 1-alpha 0 2597796900.0 951897000.0 1030989900.0 614910000.0 False True 1232249431.195075 973614405.7520417 503002689.5094074 1.0 0.7901114669680142 0.40819875974426645 30.19864716904918 -6.96185057205454 0.4085164547235721 1.019120405190022 0.16505082335515886 0.9998327955672975 0.0031677782600735517 0.07904656566788454 0.01873664047142852 0.004916029995752248 0.0319023363340738 1.091815933548437e-07 6.96185057205454 -0.8540695818348631 down NDQDTWDYTNPNLSGQGDPGSNPNK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 NDQDTWDYTNPNLSGQGDPGSNPNKR 26 1 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 68071600.0 38753000.0 25541000.0 3777600.0 True False 50805558.28458586 21730382.358038247 3386730.189297924 1.0 0.4277166336076092 0.06666062343665732 25.59848300512522 -8.352448972954493 0.4185114976736621 1.0763317827281913 3.8729842332591576e-16 0.9964266400148166 0.02297091600989031 0.1398159367764018 0.12105614192764083 0.07605325845630029 0.07914815225408099 4.441718458774815e-09 8.352448972954493 -1.0763317827281909 NDQDTWDYTNPNLSGQGDPGSNPNK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDQDTWDYTNPNLSGQGDPGSNPNKR 26 1 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 63788940.0 34965140.0 22447000.0 6376800.0 True False 33855190.769649975 31410204.15955857 4706524.780100602 1.0 0.9277810417100573 0.1390192958038163 25.01287371288653 -6.928960636779733 0.7918732983767104 1.0143156411759462 5.720714941967735e-19 0.9954226276820034 0.026383524312299095 0.09433704451903555 0.09184213265743037 0.023342350913414904 0.07255519111428096 1.1777127132240102e-07 6.928960636779733 -1.0143156411759462 down NDQDTWDYTNPNLSGQGDPGSNPNK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 NDQDTWDYTNPNLSGQGDPGSNPNKR 26 1 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 67105000.0 45094000.0 11916000.0 10095000.0 True False 68410894.81299056 9789496.699867066 8099718.825204322 1.0 0.14309850392437984 0.11839808333666561 26.027722764776303 NDQDTWDYTNPNLSGQGDPGSNPNK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NDQDTWDYTNPNLSGQGDPGSNPNKR 26 1 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 81228100.0 38753000.0 36910000.0 5565100.0 True False 53081031.36044719 35279194.154952176 4250737.99683221 1.0 0.6646290256756413 0.08008016965547518 25.661693066648112 -7.448934859409776 0.5872267768686878 1.0025876527428397 9.335016045927383e-19 0.9949671281735615 0.026966779454869687 0.11263403003150864 0.08719720041651685 0.026002242501949754 0.06873756223332808 3.5568466433413565e-08 7.448934859409776 -1.0025876527428397 down NDQDTWDYTNPNLSGQGDPGSNPNK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDQDTWDYTNPNLSGQGDPGSNPNKR 26 1 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 73071440.0 34965140.0 35195000.0 2911300.0 True False 29075063.12833942 35005397.54933943 3520039.369669688 1.0 1.2039663472035498 0.12106729929121669 24.793278988320807 -6.857976255311664 1.1958176634077846 1.1101311006068835 0.0705933301637363 0.9511434384281066 0.10385245258107158 0.1489021493592864 0.40574294830697366 0.06778668352973258 0.15790166502048694 1.3868316506621732e-07 6.857976255311664 -1.0395377704431472 down NDQDTWDYTNPNLSGQGDPGSNPNK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NDQDTWDYTNPNLSGQGDPGSNPNKR 26 1 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 91903000.0 45094000.0 28790000.0 18019000.0 True False 58375071.93563038 27187811.191556048 14739726.890553132 1.0 0.46574351499790495 0.2525003636279281 25.798849086868753 -12.231421166535343 0.15096854663446962 2.53349094017579 1.2402393453679506e-08 0.9995919502487048 0.006351067840177702 6.003833284359892 0.10498274631645456 3.0552588125082734 0.20341482449212278 5.869198980961986e-13 12.231421166535343 -2.533490927773397 NDQDTWDYTNPNLSGQGDPGSNPNKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDQDTWDYTNPNLSGQGDPGSNPNKR 26 1 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 31305600.0 9490900.0 3840700.0 17974000.0 False True 9189616.574556014 5374311.538985905 13266070.191558167 1.0 0.584824349893571 1.4435934387392113 23.13157323741884 -6.775235685927348 1.5542902020725458 0.7634612485609953 1.4494231193579263 0.7502098560558232 0.175253893133499 0.2580537002352086 1.2309425395008475 0.08883759844606763 0.21048199803245926 1.6778932003361171e-07 6.775235685927348 0.685961870796931 NDSQDK(ub)QTQFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDSQDKQTQFLR 12 1 Q9NVR2 Q9NVR2 INTS10 Integrator complex subunit 10 1 4737250.0 634470.0 320480.0 3782300.0 True False 614329.0971413197 448449.3352811214 2791602.1634322056 1.0 0.7299822478992243 4.5441477156502454 19.228652191300974 -6.889906437544539 1.0229605720078292 0.7945997586657713 4.871570729948961 0.9808374597636208 0.2405714016721863 0.11921810660883092 0.22230345509353205 0.17921415296514354 0.4466232656949261 1.2885271162965828e-07 6.889906437544539 4.07697097128319 up NDSVVAGGGAIEMELSK(ub)YLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDSVVAGGGAIEMELSKYLR 20 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 7670400.0 1963800.0 1594900.0 4111700.0 True False 1901460.2439297745 2231751.8872936275 3034722.4216440283 1.0 1.1737042067633423 1.5959957255651713 20.85867634448255 -6.95605775126477 0.48782977010041956 0.9905740990429912 1.79696716324124 0.9995949003270782 0.005037196435338217 0.08114059796207357 0.026572249237434085 0.006051929910216897 0.03482964420947514 1.106476638027659e-07 6.95605775126477 0.8063930641982489 NDSVVAGGGAIEMELSK(ub)YLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDSVVAGGGAIEMELSKYLR 20 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 5236400.0 1963800.0 1454700.0 1817900.0 True False 1632986.7110909047 1446863.2423646562 2198014.4849800887 1.0 0.8860226678746761 1.3460088009606161 20.639081619916826 -6.841131918003139 1.2771413367586573 0.939373620556637 1.3614791359939513 0.9263824372563579 0.05306865441966397 0.16747942181575723 0.5301553461431838 0.03257666557504673 0.07507402871678154 1.4416773720081091e-07 6.841131918003139 0.42210551543731434 NDSYTLHK(ub)ILPNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDSYTLHKILPNK 13 1 P62195;J3QQM1;J3QRW1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 31776100.0 6578300.0 8815800.0 16382000.0 True False 6369475.4672793755 12335994.913789654 12091062.75053445 1.0 1.9367363886023077 1.8982823330818108 22.60274313930761 -10.24526099461491 5.349841218815037 0.9999158843774864 1.9175093608421632 0.9986843122219331 0.015698802428009907 1.5751629579309837e-05 2.2222027033361076e-06 0.015201677019191447 0.005066766696537561 5.6851117437433886e-11 10.24526099461491 0.9175934764646768 NDSYTLHK(ub)ILPNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NDSYTLHKILPNK 13 1 P62195;J3QQM1;J3QRW1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 47213000.0 11531000.0 18876000.0 16806000.0 True False 17493370.029019244 15507430.321138859 13484286.733668517 1.0 0.8864747213037872 0.7708227009032464 24.06030490977804 -6.970893960225993 0.23586511253226602 1.043716220888938 0.6102531338618428 0.999988535024725 0.0003167500083665678 0.0760137290251469 0.007985081244508894 0.002847341505577805 0.011359714879218117 1.0693159375212001e-07 6.970893960225993 -0.43346308702709513 NDSYTLHK(ub)ILPNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NDSYTLHKILPNK 13 1 P62195;J3QQM1;J3QRW1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 29545400.0 5489300.0 4263100.0 19793000.0 True False 7518842.552754692 4074742.1458135163 15118301.049630739 1.0 0.5419374215145183 2.010721855598881 22.84207916049281 -6.822934360682294 1.3593042447728978 0.7538134986889845 2.0448005876659776 0.8909517679145716 0.20263063946602805 0.18970598728835023 0.6879667533682878 0.11712196950251971 0.2697359685424217 1.5033691683080855e-07 6.822934360682294 1.2909870889769932 up NDSYTLHK(ub)ILPNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDSYTLHKILPNK 13 1 P62195;J3QQM1;J3QRW1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 28447800.0 6578300.0 11982000.0 9887500.0 True False 5470147.918102302 11917450.587759221 11954930.535365306 1.0 2.1786340636824337 2.1854857883829766 22.383148414741886 -10.915443001046965 0.8668969565569585 2.7882830445381363e-10 2.1838695726983453 0.9999951430369757 0.0012280507319041192 2.9939414636218418 0.4782969644981122 6.069793570108515 0.0009516822670662266 1.2149460655307724e-11 10.915443001046965 2.1838695724195167 NDSYTLHK(ub)ILPNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NDSYTLHKILPNK 13 1 P62195;J3QQM1;J3QRW1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 41273000.0 11531000.0 18788000.0 10954000.0 True False 14927106.809991432 17742431.284020677 8960484.397531437 1.0 1.1886048321262639 0.6002827280323172 23.83143123187049 -6.820453375732143 1.3700345030423533 1.1016083654347981 0.5873257872559086 0.885401067498436 0.08303394272453396 0.1928900645181408 0.7113113192824181 0.04762680647898802 0.10975242864369573 1.511982011509202e-07 6.820453375732143 -0.5142825781788896 NDSYTLHK(ub)ILPNKVDPLVSLMMVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NDSYTLHKILPNKVDPLVSLMMVEK 25 2 P62195;J3QQM1;J3QRW1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 55082500.0 9218500.0 23576000.0 22288000.0 True False 13985138.462623684 19368678.59987125 17882767.030822575 1.0 1.384947217479146 1.2786978890924527 23.737391201783357 -10.133304415799419 4.550014750646282 0.9999622055345978 1.3318225532936157 0.9285950649612696 0.04337610670342752 30293080.727449805 0.8204092835447976 11994.99023936601 0.014848795057411652 7.356912388906563e-11 10.133304415799419 0.33186034775901785 NDSYTLHK(ub)ILPNKVDPLVSLMMVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NDSYTLHKILPNKVDPLVSLMMVEK 25 2 P62195;J3QQM1;J3QRW1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 49284500.0 9218500.0 23459000.0 16607000.0 True False 11933529.973801564 22153486.027881686 13584696.402209643 1.0 1.8564067863001676 1.1383636218313433 23.508517523875806 -10.13568279182202 4.280683962974208 0.9999028012651133 1.4973852041013633 0.3901580928847298 0.29313989452249406 42058066.580336094 33194668.591307543 34594.72165152208 0.10034958321150897 7.316733016811271e-11 10.13568279182202 0.49748240283625 NDTK(ub)EDVFVHQTAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDTKEDVFVHQTAIK 15 1 P67809;Q9Y2T7;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX2;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 2;Y-box-binding protein 3 1 74888900.0 27483400.0 22517500.0 24888000.0 True False 26610954.510652542 31508855.177211218 18369086.176004246 1.0 1.1840558054615444 0.6902828746203364 24.665516923654252 -6.8057540191340715 1.4321986408692637 1.1008253786416702 0.6824504541188031 0.8484677911835989 0.07931259845931475 0.21265482423648163 0.8604407829011304 0.04355299439946672 0.1009595482007201 1.5640332475412824e-07 6.8057540191340715 -0.41837492452286706 NDTK(ub)EDVFVHQTAIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NDTKEDVFVHQTAIK 15 1 P67809;Q9Y2T7;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX2;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 2;Y-box-binding protein 3 1 125349300.0 43857300.0 7474800.0 74017200.0 True False 66534730.49811 6140863.53912103 59387667.97710873 1.0 0.09229561002423342 0.8925814763583616 25.987604274566905 -9.576540258609914 11.295181301474601 1.0000371751914854 0.49243854319166064 0.3490948360567282 0.3267153375182938 0.0 0.0 0.3163407649711714 0.10544692165705713 2.6513053085978913e-10 9.576540258609914 -0.5075986319998247 NDTK(ub)EDVFVHQTAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDTKEDVFVHQTAIK 15 1 P67809;Q9Y2T7;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX2;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 2;Y-box-binding protein 3 1 86060500.0 27483400.0 38021900.0 20555200.0 True False 22853664.821059007 37817068.477943756 24853197.283493403 1.0 1.654748539196934 1.0874928585017087 24.44592219908853 -10.386045434936563 3.9880773443031656 0.9986854876706724 1.3711206988622309 0.36334305509533227 0.23158116197949183 21298800.25597704 55473089.17288437 154810.4478021124 0.07927639546315193 4.111067097720075e-11 10.386045434936563 0.3724352111915584 NDTK(ub)EDVFVHQTAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NDTKEDVFVHQTAIK 15 1 P67809;Q9Y2T7;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX2;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 2;Y-box-binding protein 3 1 130970300.0 43857300.0 45896500.0 41216500.0 True False 56774139.40662889 43342319.428733975 33715519.91700331 1.0 0.7634165815937206 0.5938534739474487 25.758730596659355 -7.307152005523247 0.10505031388764384 1.4092879015032533 3.3601464756728435e-12 0.9999986088911187 0.0001963641139495701 0.10997316028959846 0.006080863372918114 0.030548774012553195 0.048750466487391425 4.930012205405389e-08 7.307152005523247 -1.4092879014998931 NDTK(ub)EDVFVHQTAIK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 NDTKEDVFVHQTAIKK 16 2 P67809;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 2 15021300.0 3819500.0 3220100.0 7981700.0 True False 5794460.742853086 2645447.9962438694 6404113.496496619 1.0 0.4565477468298973 1.1052130268369633 22.466242973470205 -6.684448681641585 1.8859399132348986 0.657538510582929 1.1028457727709517 0.3446690154530253 0.23010661146253925 0.4287109428845288 2.95175236264449 0.09776472651092528 0.256400970968382 2.06800373290989e-07 6.684448681641585 0.44530726218802275 NDTKEDVFVHQTAIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDTKEDVFVHQTAIKK 16 2 P67809;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 1 133785000.0 17391000.0 27400000.0 88994000.0 True False 16838932.224352114 38340962.88911235 65683801.637227505 1.0 2.276923642086073 3.9007106128877314 24.00529732259966 -6.967856353765972 0.30507702973712847 0.7348442480127253 5.494040360826936 0.9999605023560246 0.007460136723009672 0.07700460444354539 0.011506879044786714 0.02628383011224094 0.14486615376083312 1.0768213216528984e-07 6.967856353765972 4.759196112814211 NDTKEDVFVHQTAIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDTKEDVFVHQTAIKK 16 2 P67809;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 1 101492000.0 17391000.0 32062000.0 52039000.0 True False 14461387.051930899 31889275.642191257 62920114.29884969 1.0 2.205132573222523 4.350904520631618 23.785702598033936 -6.962252710685156 0.40242826033184587 0.8851574074074208 5.7495384049439915 0.9998448402111554 0.017262593904387724 0.07890600621392897 0.018228489837637078 0.027604525300091054 0.17962048829280555 1.0908054253123579e-07 6.962252710685156 4.86438099753657 NDTKEDVFVHQTAIK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NDTKEDVFVHQTAIKK 16 2 P67809;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 1 608467000.0 77727000.0 338510000.0 192230000.0 True False 100619133.72822857 319671620.9257949 157246112.4463637 1.0 3.1770460456281135 1.5627853929957707 26.58432943312964 -6.569530545019081 2.3076051107508824 2.4916753882376312 1.5659932167465787 0.0 0.9482582898039146 0.7313953961005936 7.310150745309143 0.34729931767718686 1.0635734553543341 2.694445818560437e-07 6.569530545019081 -0.9256821714910526 NDTKEDVFVHQTAIK(ub)K(ub)NNPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NDTKEDVFVHQTAIKKNNPR 20 3 P67809;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 2 4659070.0 1984170.0 1273500.0 1401400.0 True False 2601266.0847296123 1083498.7640641197 1256396.5711780246 1.0 0.4165274634627559 0.48299425366498805 21.31078255010666 -10.290642020042052 5.634861784515296 1.0000553882071788 0.4497608585656447 0.9891746804357726 0.027134953472709333 1.8883166913572067e-05 2.377134499919976e-06 0.02627593667522984 0.008757768574988981 5.1210377816848327e-11 10.290642020042052 -0.550294529641534 NDTKEDVFVHQTAIK(ub)K(ub)NNPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDTKEDVFVHQTAIKKNNPR 20 3 P67809;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 2 8641400.0 1371600.0 2524700.0 4745100.0 True False 1328059.308775883 3532825.876136572 3502215.960051335 1.0 2.6601416463794054 2.6370930401289425 20.340888145652265 -10.468389652264573 4.928835391788632 0.9960472443901724 2.6486173432543065 0.9998534292276586 0.009409554099786142 0.0004088574686171339 4.4098194856689144e-05 0.00911405377259928 0.0030369205269101637 3.401029098916952e-11 10.468389652264573 1.652570098864134 NDTKEDVFVHQTAIK(ub)K(ub)NNPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NDTKEDVFVHQTAIKKNNPR 20 3 P67809;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 2 47896000.0 14974000.0 9532000.0 23390000.0 True False 22716652.746035375 7830940.126144081 18766956.247798834 1.0 0.34472244717086575 0.8261321092331324 24.437246936446094 -9.885491684214431 6.383008820899439 1.0000000318921896 0.5854272782021231 0.49718545157979654 0.19653467154986248 8.920867827996289e-08 1.554846753672965e-08 0.19029389164412783 0.06343129248872384 1.3016922398883727e-10 9.885491684214431 -0.4145727536900664 NDTKEDVFVHQTAIK(ub)K(ub)NNPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NDTKEDVFVHQTAIKKNNPR 20 3 P67809;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 2 5413670.0 1984170.0 1010200.0 2419300.0 True False 2717771.269178088 965566.0237153261 1847911.167047523 1.0 0.3552786191633168 0.6799362359902976 21.37399261162955 -10.57943379345953 6.546846018858215 1.000851174133392 0.5176074275769427 0.7464289331823128 0.1325409170556868 0.0016492871059346917 0.00010594914429354536 0.1285374045759096 0.04277739703731113 2.6336994105227077e-11 10.57943379345953 -0.4832437465564494 NDTKEDVFVHQTAIK(ub)K(ub)NNPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDTKEDVFVHQTAIKKNNPR 20 3 P67809;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 2 9862600.0 1371600.0 5894800.0 2596200.0 True False 1140546.1721826484 5863043.542373809 3139053.416527475 1.0 5.140557818149333 2.752237036156379 20.12129342108654 -9.495791973799758 8.68310149725211 0.9998591605969939 3.9463974271529776 0.6698855475365202 0.9750278797186912 0.0 0.0 0.944066683527501 0.3146888945091669 3.1930669616287296e-10 9.495791973799758 2.946538266555984 NDTKEDVFVHQTAIK(ub)K(ub)NNPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NDTKEDVFVHQTAIKKNNPR 20 3 P67809;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 2 119500000.0 14974000.0 47471000.0 57055000.0 True False 19384138.18166781 44829197.11963723 46671575.43373704 1.0 2.312674244245412 2.407719909770135 24.208373258538543 -10.703158386948301 0.4958760362861708 5.265389151828022e-24 2.4042999656779345 0.9996843457959842 0.011412875022692073 2.2413797641603166 0.2381369270588051 2.735252661894958 0.019456200008019127 1.980804495797167e-11 10.703158386948301 2.4042999656779345 NDTKEDVFVHQTAIKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 NDTKEDVFVHQTAIKK 16 2 P67809;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 1 96224000.0 18984000.0 16970000.0 60270000.0 True False 24888207.84131754 14438142.14854191 54033838.55066333 1.0 0.5801197997299262 2.171061849658793 24.56895901218691 -6.836539679906341 1.2983705729030377 0.7764419457222513 2.219905725122613 0.9183433667678234 0.1923710514251946 0.1728754270003169 0.5675898249288673 0.11624226216289009 0.26760216294573425 1.4570025776256025e-07 6.836539679906341 1.4434637794003615 up NDTKEDVFVHQTAIKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NDTKEDVFVHQTAIKK 16 2 P67809;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 3 1 69901000.0 18984000.0 16211000.0 34706000.0 True False 26002897.82330994 15494744.417391764 26509157.592506647 1.0 0.5958852941190929 1.0194693596320206 24.6321690737098 -10.976680706154635 12.553730306134243 1.098013604469491 0.8076773268756207 0.21560362511348252 0.1729274706133857 0.07983362456211111 0.00014829556755313833 0.02817803309839309 0.05581210114895129 1.0551623679829275e-11 10.976680706154635 -0.2903362775938704 NDVLK(ub)QEVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NDVLKQEVQR 10 1 A0A0B4J2A0;Q9UHJ6 A0A0B4J2A0 TRPV1;SHPK Sedoheptulokinase 1 3338450.0 642350.0 1062300.0 1633800.0 True False 842127.0705262481 903808.9808129672 1464750.048516238 1.0 1.0732453716850283 1.7393456400836407 19.683678415788187 -6.927791471223598 0.7646940669919629 0.9889983613659303 1.8687109870032579 0.9960863927157533 0.020807918783318054 0.09380028545028092 0.08341477218001771 0.018713902290509555 0.06101853283422728 1.1808875088866755e-07 6.927791471223598 0.8797126256373275 NDVLK(ub)QEVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NDVLKQEVQR 10 1 A0A0B4J2A0;Q9UHJ6 A0A0B4J2A0 TRPV1;SHPK Sedoheptulokinase 1 5980030.0 920030.0 1447900.0 3612100.0 True False 890824.1512489609 2026054.0206987541 2665982.649322763 1.0 2.2743591065174518 2.992714831075223 19.764781146184863 -8.882648198445429 0.20511914703460277 4.282698367754145e-18 3.73600046587577 0.9995651212344119 0.017183703784392396 0.3858759692857861 0.06495703066693737 0.6308325164855337 0.37093339049295637 1.3102428594129972e-09 8.882648198445429 3.73600046587577 NDVLK(ub)QEVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NDVLKQEVQR 10 1 A0A0B4J2A0;Q9UHJ6 A0A0B4J2A0 TRPV1;SHPK Sedoheptulokinase 1 3200750.0 642350.0 1014400.0 1544000.0 True False 879844.1538560425 969580.4538277839 1179338.9996781617 1.0 1.1019911305638155 1.340395335366542 19.746888477311078 -6.956885532513128 0.47730961273347094 0.994130203436793 1.4581508323974908 0.9996366670096595 0.0027188392704905924 0.08083305641997383 0.025389206101381734 0.0033433025827839763 0.019668434737076846 1.1043696615037174e-07 6.956885532513128 0.46402062896069773 NDVLK(ub)QEVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NDVLKQEVQR 10 1 A0A0B4J2A0;Q9UHJ6 A0A0B4J2A0 TRPV1;SHPK Sedoheptulokinase 1 6054730.0 920030.0 2461300.0 2673400.0 True False 765045.709239721 2448040.4883702043 3232395.5795950103 1.0 3.1998617321872076 4.225101246312807 19.54518642161914 -9.018397736963385 0.2855302251872607 3.7874805397568434e-14 4.746697837913449 0.9987927441554353 0.04674796878141646 0.47941962929730125 0.0989226763130529 0.8734460619724459 0.36987186913468884 9.585223923740642e-10 9.018397736963385 4.746697837913411 NDVLK(ub)QEVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NDVLKQEVQR 10 1 A0A0B4J2A0;Q9UHJ6 A0A0B4J2A0 TRPV1;SHPK Sedoheptulokinase 1 11021900.0 2207800.0 0.0 8814100.0 True False 2858040.622244302 0.0 7210024.240303245 1.0 0.0 2.522715801933392 21.446594991389084 -6.79916479642606 1.4594112449258687 0.4476641370610185 2.5567878615720505 0.8296752914885622 0.4280722949145549 0.2219584226078805 0.9334143489447003 0.23076588686632063 0.536930013117801 1.5879440765043925e-07 6.79916479642606 2.109123724511032 NDYDQLQK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NDYDQLQKAR 10 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 5214070.0 909270.0 1183300.0 3121500.0 True False 1177067.939391286 1117448.3147957032 2553419.029294721 1.0 0.9493490370433376 2.1693047137238373 20.16676616327244 -6.8972136616081094 0.9787237896255022 0.9453286597962045 2.290350043206174 0.9851280732415157 0.06872320723734601 0.11348510349004794 0.18921632827777507 0.052927401208905704 0.13587907062029891 1.267028367441065e-07 6.8972136616081094 1.3450213834099694 up NEAELSLVLSHCTGATDGATADK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NEAELSLVLSHCTGATDGATADK 23 0 Q9H269-2;Q9H269 Q9H269-2 VPS16 Vacuolar protein sorting-associated protein 16 homolog 0 14767900.0 4610600.0 6927600.0 3229700.0 False True 6044541.249113915 5894029.083573306 2895521.625470009 1.0 0.9750994890534211 0.47903083230583815 22.52720141951109 -6.917327079065613 0.8443112874198149 1.0120350810133965 0.40375428552137266 0.9934056653549378 0.019483925992306587 0.09977030562353656 0.11395157891122477 0.016553965174476416 0.048387975509611846 1.209686742189041e-07 6.917327079065613 -0.6082807954920237 down NEAELSLVLSHCTGATDGATADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NEAELSLVLSHCTGATDGATADK 23 0 Q9H269-2;Q9H269 Q9H269-2 VPS16 Vacuolar protein sorting-associated protein 16 homolog 0 15200500.0 6888800.0 4519700.0 3792000.0 False True 6670118.814738469 6324439.779924131 2798761.442438447 1.0 0.9481749809238005 0.4195969397507928 22.669281029670657 -6.925875818266598 0.779900931999157 1.0093845620109494 0.32166309532928095 0.9956637459491808 0.01726884392156305 0.09483653522499425 0.08859051675306688 0.015362574610094373 0.04895646503935628 1.1861078541864193e-07 6.925875818266598 -0.6877214666816684 down NEAELSLVLSHCTGATDGATADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEAELSLVLSHCTGATDGATADK 23 0 Q9H269-2;Q9H269 Q9H269-2 VPS16 Vacuolar protein sorting-associated protein 16 homolog 0 11771200.0 4610600.0 4333200.0 2827400.0 False True 6315263.416780063 4141744.8960238146 2159626.352130851 1.0 0.6558309008962209 0.34196932251354456 22.590411481033982 -7.409315556523955 0.2503489576433915 1.1258012129086494 1.0951555292052915e-15 0.9999043745205844 0.002627905678302005 0.11909076514912194 0.020728043283413967 0.02133360458914187 0.0574185561974664 3.896587593953653e-08 7.409315556523955 -1.1258012129086483 down NEAELSLVLSHCTGATDGATADK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NEAELSLVLSHCTGATDGATADK 23 0 Q9H269-2;Q9H269 Q9H269-2 VPS16 Vacuolar protein sorting-associated protein 16 homolog 0 15845000.0 6888800.0 6798000.0 2158200.0 False True 5728342.425584582 6761377.824702653 2609469.641610663 1.0 1.1803375780233056 0.4555366016451722 22.449686305104933 -6.840851620900784 1.2785507635571052 1.0959236739472797 0.43130980212581155 0.9258898408273912 0.08387305007768603 0.16780733676844 0.5325062729282757 0.05143341890184906 0.11851322338752397 1.4426081423467422e-07 6.840851620900784 -0.6646138718214682 down NEALIALLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NEALIALLR 9 0 P13796 P13796 LCP1 Plastin-2 0 70557000.0 25824000.0 17461000.0 27272000.0 False True 33855514.079971716 14855886.862444917 24450155.051496416 1.0 0.4388025781369948 0.7221912210147376 25.01288749027074 -10.280003569760233 4.965697246540838 1.0001115440896058 0.5804968995756703 0.7450122961570189 0.11569292899252923 0.00014290731961477682 2.072080825696755e-05 0.11204879623933003 0.03733973227171853 5.248031465198499e-11 10.280003569760233 -0.4196146445139355 NEALIALLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NEALIALLR 9 0 P13796 P13796 LCP1 Plastin-2 0 69126000.0 22149000.0 16599000.0 30378000.0 False True 21445892.11874964 23227067.26264145 22421090.47953458 1.0 1.0830543739579184 1.0454725014648538 24.354197995504464 -10.249436090158179 4.187509618244938 0.9999537652283608 1.0642634377143627 0.7958604435910795 0.015342735207716757 6.6273787680450456e-06 1.1879026331326875e-06 0.014866224952034955 0.004951846494014478 5.630719717579959e-11 10.249436090158179 0.06430967248600195 NEALIALLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NEALIALLR 9 0 P13796 P13796 LCP1 Plastin-2 0 35835000.0 4140200.0 25906000.0 5788800.0 False True 6280986.089163606 21282871.895498138 4644641.142678833 1.0 3.3884602820911875 0.7394764256351547 22.582559643451766 -6.669166154464798 1.9402613461723637 2.5256303658131705 0.7502090929498296 0.27538386801813164 1.0147602377510574 0.46303746581621225 3.3598229627751004 0.4211589823216962 1.1264837834445698 2.142070920569995e-07 6.669166154464798 -1.775421272863341 NEALIALLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEALIALLR 9 0 P13796 P13796 LCP1 Plastin-2 0 100722000.0 25824000.0 23933000.0 50965000.0 False True 35371830.667359605 22875560.924152594 38928116.65712275 1.0 0.6467169070008494 1.1005400603436908 25.07609755179363 -6.698968805057311 1.8346325514434931 0.7804008165433483 1.099159643050156 0.4126188140939241 0.14915398897531665 0.39768602443108014 2.601654581208775 0.06487774110981177 0.1670558405701532 2.0000055228901742e-07 6.698968805057311 0.31875882650680776 NEALIALLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NEALIALLR 9 0 P13796 P13796 LCP1 Plastin-2 0 42203000.0 22149000.0 10000000.0 10054000.0 False True 18417874.86707018 9946128.015155407 12156244.915556312 1.0 0.5400258220310944 0.6600242972271895 24.13460327093874 -10.171707723693503 7.856270143646718 1.0000001243783818 0.6000250596291534 0.9367622320475534 0.04898917235707609 1.0673416752447574e-07 1.1246042750206888e-08 0.0474335770137387 0.015811187390286703 6.734297159973461e-11 10.171707723693503 -0.3999750647492284 NEALIALLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NEALIALLR 9 0 P13796 P13796 LCP1 Plastin-2 0 16388000.0 4140200.0 7368700.0 4879100.0 False True 5359570.515543022 6958625.36739212 3991153.863793651 1.0 1.2983550355782723 0.7446779274979414 22.353685965544216 -6.76034186349938 1.611088249264997 1.1732295296492776 0.7426152983468236 0.6923746316288162 0.12549569229203528 0.28235597139029334 1.4445070017246877 0.06145602197586783 0.14764428920515674 1.73643342268388e-07 6.76034186349938 -0.430614231302454 NEDDVK(ub)SLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NEDDVKSLSR 10 1 Q07820;A0A087WT64 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 16012900.0 3544500.0 10781800.0 1686600.0 True False 4646873.824986829 9173197.467127241 1512086.8110096026 1.0 1.974057788658215 0.3253987235200836 22.147829041687963 -6.746587260125759 1.6622315890625579 1.5750774112838402 0.32290374088365237 0.6342965305674606 0.4092557214092794 0.30601570264246697 1.6624266082032657 0.19457594131614678 0.4741278674676571 1.7923083986546565e-07 6.746587260125759 -1.2521736704001878 NEDDVK(ub)SLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NEDDVKSLSR 10 1 Q07820;A0A087WT64 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 28235700.0 20148200.0 4607500.0 3480000.0 True False 19508606.419567104 6447298.777795084 2568483.602237813 1.0 0.33048484546433066 0.1316589994691588 24.217607388166293 -12.052431639752491 0.20474438821926516 2.6417583379904266 2.7361906838294664e-24 0.9993853522834919 0.009209103116212806 5.431917835584168 0.1292272662966863 3.8874145143478347 0.12051032137391483 8.8627471700679e-13 12.052431639752491 -2.6417583379904266 NEDDVK(ub)SLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NEDDVKSLSR 10 1 Q07820;A0A087WT64 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 66718700.0 26670000.0 29398100.0 10650600.0 True False 40460339.83817039 24151779.366596326 8545504.241676187 1.0 0.5969247777748885 0.2112069319203873 25.27000510177417 -7.667639619814379 0.3443352977966962 1.0698593847712168 4.4094190973815593e-11 0.9991598852319555 0.009334514460633799 0.12293591729291159 0.04892305819583684 0.029241868856975495 0.07511383172275365 2.1496134965168466e-08 7.667639619814379 -1.0698593847271225 down NEDDVK(ub)SLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEDDVKSLSR 10 1 Q07820;A0A087WT64 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 15304800.0 3544500.0 9379100.0 2381200.0 True False 4854997.436510853 8964700.349463897 1818809.602353393 1.0 1.8464892034848468 0.37462627450129393 22.211039103210855 -6.750741407428266 1.6470943198132237 1.4972957210487505 0.3715322178547599 0.6521735881519639 0.3557136017522913 0.29874608550697757 1.5948315859203168 0.17058654440017368 0.4138172162586465 1.775246203589835e-07 6.750741407428266 -1.1257635031939905 NEDDVK(ub)SLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NEDDVKSLSR 10 1 Q07820;A0A087WT64 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 47674000.0 20148200.0 24824600.0 2701200.0 True False 16754121.016601367 24690864.95250268 3266008.4310623286 1.0 1.4737189093976897 0.19493761730777148 23.99801266360057 -6.806391066745753 1.4295351273765837 1.2592925346536672 0.1743377423524324 0.8502366659563293 0.2042816630275984 0.21175402427999537 0.8535107152112251 0.11238340130929764 0.26043031663666044 1.561740717282581e-07 6.806391066745753 -1.0849547923012348 down NEDDVK(ub)SLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NEDDVKSLSR 10 1 Q07820;A0A087WT64 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 1 62056300.0 26670000.0 28606800.0 6779500.0 True False 34524840.74429546 27014806.432601795 5545700.563544304 1.0 0.7824744691129516 0.16062928731859885 25.04113142386662 -7.101974325527764 0.5961069907976908 1.003434896428124 1.689516401139559e-22 0.9988018152136922 0.012311671793848794 0.07712637884182684 0.04353176015449465 0.012616236954518072 0.046815600577629714 7.907253724494823e-08 7.101974325527764 -1.003434896428124 down NEDFK(ub)YVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NEDFKYVR 8 1 Q8NAV1 Q8NAV1 PRPF38A Pre-mRNA-splicing factor 38A 1 4171450.0 707060.0 784990.0 2679400.0 True False 926962.5071787809 667872.5518670548 2402161.390619669 1.0 0.7204957554321493 2.591433172341209 19.82215146183009 -6.868878175825757 1.1400698405696676 0.8429581918034169 2.698667323874543 0.9635477595803126 0.15732716434243224 0.13793204634735193 0.3357785024912819 0.1071719866043185 0.25324133830012974 1.352451886981973e-07 6.868878175825757 1.855709132071126 up NEDFK(ub)YVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NEDFKYVR 8 1 Q8NAV1 Q8NAV1 PRPF38A Pre-mRNA-splicing factor 38A 1 10525450.0 857240.0 1749410.0 7918800.0 True False 830027.3854294532 2447958.5360526294 5844628.721092182 1.0 2.9492503247782174 7.041489020351048 19.66279941110299 -6.959085192312922 0.44814016574382304 0.8654962815334902 9.286969402906943 0.9997347517226991 0.04100303860189157 0.0800295405801463 0.022351064114573164 0.0545479149013101 0.33859149822995455 1.098790276788194e-07 6.959085192312922 8.421473121373452 NEDFK(ub)YVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NEDFKYVR 8 1 Q8NAV1 Q8NAV1 PRPF38A Pre-mRNA-splicing factor 38A 1 25105100.0 3428200.0 6659900.0 15017000.0 True False 5200830.03499122 5471388.810963805 12048883.367815096 1.0 1.0520222299425792 2.3167231551021907 22.310310460232333 -6.91555276449244 0.8570551529125151 0.9673779515699585 2.5011763005748135 0.9928538809531209 0.05146626247206692 0.10085974552680965 0.11969414627362081 0.04332910234012366 0.12475259361517284 1.2146390392595794e-07 6.91555276449244 1.533798349004855 up NEDFK(ub)YVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NEDFKYVR 8 1 Q8NAV1 Q8NAV1 PRPF38A Pre-mRNA-splicing factor 38A 1 9461340.0 857240.0 1050700.0 7553400.0 True False 712833.0421710802 1045039.6705523798 9132781.01702437 1.0 1.466037078429327 12.811949610540779 19.443204686537268 -6.9155408493526425 0.85713743366241 0.7072219574932179 14.4662968177176 0.9928501383092245 0.4618220865564017 0.10086715094489772 0.11973231970736022 0.388781307009994 1.1192679252704105 1.2146723640958217e-07 6.9155408493526425 13.759074860224382 up NEDFK(ub)YVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NEDFKYVR 8 1 Q8NAV1 Q8NAV1 PRPF38A Pre-mRNA-splicing factor 38A 1 28210600.0 3428200.0 6320600.0 18461800.0 True False 4437872.4799247775 5968853.053746057 15101941.834064784 1.0 1.3449807493899035 3.4029688555451156 22.081436782324783 -6.935956544265616 0.6961593976299841 0.974511188515535 3.8976154206943066 0.9975849372380932 0.05213355795043157 0.08966055730868668 0.06337751523845726 0.04931000360110362 0.18050598765459352 1.1588933098282258e-07 6.935956544265616 2.9231042321787717 up NEEATK(ub)HLECTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NEEATKHLECTK 12 1 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 27184400.0 7810200.0 11746000.0 7628200.0 True False 10239247.834084392 9993542.585549396 6838907.038861291 1.0 0.9760035841971622 0.6679110760554059 23.287606404364652 -6.922442487504109 0.8064100702337206 1.0062182075222177 0.6153266352424995 0.9948328018335626 0.010869453089008429 0.09675596324286158 0.09832476803580649 0.009488356737519785 0.029120877714588333 1.195521835058264e-07 6.922442487504109 -0.39089157227971816 NEEATK(ub)HLECTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NEEATKHLECTK 12 1 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 19263900.0 8160000.0 6864000.0 4239900.0 True False 7900965.266558169 9604830.995287139 3129342.99572647 1.0 1.2156528564858773 0.39607097236230215 22.913597488462848 -6.836771261754597 1.2973433217219232 1.1148114899797157 0.3707984803431072 0.9187524099960737 0.09887542645309218 0.17260425462927276 0.5657145426986558 0.05979215933896978 0.13765047002161515 1.4562258571773235e-07 6.836771261754597 -0.7440130096366084 down NEEATK(ub)HLECTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NEEATKHLECTK 12 1 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 45051700.0 9228700.0 11159000.0 24664000.0 True False 14000612.608343588 9167589.26433506 19789149.589384764 1.0 0.6547991520650808 1.4134488356310586 23.738986619073433 -6.7829775824142065 1.5241206531590272 0.8052961842423254 1.4200457702860247 0.777839436060096 0.14617871020979145 0.2459713769801447 1.1287151067181964 0.07552456629108176 0.1777790773055783 1.6482474692250035e-07 6.7829775824142065 0.6147495860436993 NEEATK(ub)HLECTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEEATKHLECTK 12 1 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 26644200.0 7810200.0 10120000.0 8714000.0 True False 10697842.002718875 9672864.937635228 6655932.670463402 1.0 0.904188427458253 0.6221752638309469 23.350816465887544 -6.95187787370084 0.5378316213353391 1.0042122181601119 0.5091763566596419 0.9993405369364591 0.004118263874440053 0.08274030847085173 0.03290844647502301 0.004543233320547155 0.023346780145511576 1.1171773608090138e-07 6.95187787370084 -0.49503586150046996 NEEATK(ub)HLECTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NEEATKHLECTK 12 1 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 18097000.0 8160000.0 6763900.0 3173100.0 True False 6785401.549293084 6727461.528170974 3836580.5392432585 1.0 0.9914610770341004 0.5654168749442634 22.694002763897124 -6.9112347610279095 0.887287514487505 1.0126815984594868 0.5088791039807746 0.9913791765735844 0.018837243563485213 0.1036070632241485 0.13438137811575793 0.015517084482504788 0.04320944301124933 1.2267759092891907e-07 6.9112347610279095 -0.5038024944787122 NEEATK(ub)HLECTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NEEATKHLECTK 12 1 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 1 36819700.0 9228700.0 8119000.0 19472000.0 True False 11946734.074873641 7667170.512825416 15928295.79959211 1.0 0.6417796248558844 1.3332761656671077 23.510112941165882 -6.765894691370534 1.5901790576769839 0.7934693102162815 1.336579420803155 0.7146859848051419 0.15082387903489833 0.27307889418355313 1.3621112619471218 0.0747909814201619 0.1787117061046006 1.7143729618343466e-07 6.765894691370534 0.5431101105868734 NEEDAAELVALAQAVNAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NEEDAAELVALAQAVNAR 18 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 13889800.0 0.0 6775100.0 7114700.0 False True 0.0 5764281.489132953 6378539.093021473 0.0 NEEDAAELVALAQAVNAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEEDAAELVALAQAVNAR 18 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 14858600.0 0.0 7345300.0 7513300.0 False True 0.0 7020760.358341116 5738813.28127068 0.0 NEEEGNSEEIK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NEEEGNSEEIKAK 13 1 O75844 O75844 ZMPSTE24 CAAX prenyl protease 1 homolog 1 6490400.0 463200.0 4262200.0 1765000.0 True False 702708.2644559632 3501577.1092794035 1416146.97637302 1.0 4.982974139332665 2.0152701312960954 19.422566340437758 -6.570921610612117 2.3017829664715808 3.7269279185927546 2.0213343846492977 0.0 1.734282707660599 0.7272958466686009 7.234181099959476 0.6361587330909314 1.944620670752138 2.6858291893403454e-07 6.570921610612117 -1.705593533943457 NEEEKRRGLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NEEEKRRGLDK 11 3 K7ELZ8;K7EIY1;K7ENN5;Q9Y421-3;Q9Y421-2;Q9Y421 K7ELZ8 FAM32A Protein FAM32A 0 51499000.0 16285000.0 16492000.0 18722000.0 False True 21349792.70416431 14031457.885312505 16784827.034105167 1.0 0.6572175233615101 0.7861822017049964 24.347718726276224 -10.09814024917972 5.609678185263412 1.000002428680614 0.7216998630687943 0.8612851532450351 0.052649609464143265 1.5992263001736259e-06 2.570198986566478e-07 0.05097821025315732 0.016992588386551224 7.977370279245028e-11 10.09814024917972 -0.27830256561181965 NEEEKRRGLDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NEEEKRRGLDK 11 3 K7ELZ8;K7EIY1;K7ENN5;Q9Y421-3;Q9Y421-2;Q9Y421 K7ELZ8 FAM32A Protein FAM32A 0 100342000.0 31442000.0 28909000.0 39991000.0 False True 47699812.71810103 23749963.082952086 32086761.321322057 1.0 0.49790474489514075 0.6726810755201527 25.507480266056636 -10.034852112216214 5.6521684153948994 1.000001453995467 0.5852929102074959 0.8824473595842257 0.07135213819174176 1.3073550119783543e-06 2.232101885367105e-07 0.06908665314773017 0.023028803577664517 9.228856385530827e-11 10.034852112216214 -0.41470854378797106 NEEEKRRGLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEEEKRRGLDK 11 3 K7ELZ8;K7EIY1;K7ENN5;Q9Y421-3;Q9Y421-2;Q9Y421 K7ELZ8 FAM32A Protein FAM32A 0 47854000.0 16285000.0 14657000.0 16912000.0 False True 22306004.585577406 14009405.275782552 12917733.913573232 1.0 0.6280553391816631 0.5791146444005292 24.410928787799115 -13.999999999999998 0.2858721105640592 4.131674683432674 0.5652146456954316 0.999618234121348 0.003672062603803417 15.724967346070146 0.16947113708768582 28.891214634055768 0.01883503327180383 1.0000000000000041e-14 13.999999999999998 -3.566460037737243 NEEEKRRGLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NEEEKRRGLDK 11 3 K7ELZ8;K7EIY1;K7ENN5;Q9Y421-3;Q9Y421-2;Q9Y421 K7ELZ8 FAM32A Protein FAM32A 0 34055000.0 13615000.0 10212000.0 10228000.0 False True 11321475.746767819 10156985.929076696 12366627.511071201 1.0 0.8971432838140757 1.0923158594940032 23.432558688969426 -6.763530184600395 1.5993735962822035 0.9405180263232663 1.0931514641350253 0.7051578016424433 0.04328615518193993 0.27701715593072584 1.3973691704993358 0.021347203571730016 0.05111954461330523 1.723732282969352e-07 6.763530184600395 0.15263343781175898 NEEEKRRGLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NEEEKRRGLDK 11 3 K7ELZ8;K7EIY1;K7ENN5;Q9Y421-3;Q9Y421-2;Q9Y421 K7ELZ8 FAM32A Protein FAM32A 0 175004000.0 31442000.0 92652000.0 50910000.0 False True 40702288.81447841 87495834.75234638 41644902.38071252 1.0 2.1496539212119887 1.0231587361224463 25.278606588149085 -6.641422222113344 2.039037499278998 1.7509823316039042 1.0278274538794354 0.16018935541787072 0.49172531909844047 0.5297907350671393 4.211466342328563 0.1962521681652666 0.5446018951106153 2.2833778186592828e-07 6.641422222113344 -0.7231548777244687 NEELAQTWK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 NEELAQTWKR 10 1 Q8TAT6;Q8TAT6-2;I3L283;I3L3I1;I3L281 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 11188500.0 1816600.0 2732800.0 6639100.0 True False 2381580.191979426 2325076.8923709653 5952149.6187441265 1.0 0.9762748700216983 2.499243837679494 21.18348769691472 -6.903362155907438 0.9397627481113943 0.9423883028486607 2.6704874590009737 0.9881661939117451 0.07749811768061618 0.10897277140670973 0.16378892968505157 0.06143607844887601 0.16271965157965868 1.249216880303598e-07 6.903362155907438 1.7280991561523131 up NEELAQTWK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 NEELAQTWKR 10 1 Q8TAT6;Q8TAT6-2;I3L283;I3L3I1;I3L281 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 24973200.0 0.0 3915400.0 21057800.0 True False 0.0 5478839.638541257 15542130.459541203 0.0 NEELAQTWK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 NEELAQTWKR 10 1 Q8TAT6;Q8TAT6-2;I3L283;I3L3I1;I3L281 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 157464300.0 9715300.0 18359000.0 129390000.0 True False 14738820.38356868 15082693.01047828 103816009.78634848 1.0 1.023331081997102 7.0437122567886075 23.813117727662405 -6.907748347452802 0.9109144534282919 0.8000641246694994 7.785450295234231 0.9900441728524746 0.28372627066140427 0.1059263619729595 0.14697661735831433 0.22973477326843855 0.6247148119921152 1.2366638124531988e-07 6.907748347452802 6.985386170564731 up NEELAQTWK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEELAQTWKR 10 1 Q8TAT6;Q8TAT6-2;I3L283;I3L3I1;I3L281 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 17199700.0 1816600.0 2188500.0 13194600.0 True False 2488246.111769112 2091804.833598291 10078307.231317004 1.0 0.840674410663921 4.050365911815473 21.246697758437612 -6.895223261058094 0.9909830344227307 0.8485069368851849 4.356407508606781 0.9840359052143839 0.18661037305935976 0.11500693057782609 0.19791597886130927 0.14240574836782413 0.362384178974918 1.2728485698784513e-07 6.895223261058094 3.5079005717215956 up NEELAQTWK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NEELAQTWKR 10 1 Q8TAT6;Q8TAT6-2;I3L283;I3L3I1;I3L281 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 22133400.0 0.0 3200200.0 18933200.0 True False 0.0 3182959.887410038 22892044.582774073 0.0 NEELAQTWK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NEELAQTWKR 10 1 Q8TAT6;Q8TAT6-2;I3L283;I3L3I1;I3L281 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 160697300.0 9715300.0 76352000.0 74630000.0 True False 12576647.367193615 72102944.08119786 61048105.76846552 1.0 5.733081478397775 4.854084239310906 23.584244049754854 -10.092076502401351 5.4762729125115035 0.999954211544519 5.293582858856079 0.9695241913218788 0.3588491201857931 0.0002006250570453885 3.326116868558344e-05 0.3474577546515775 0.11581805552250919 8.089533868270608e-11 10.092076502401351 4.293628647311561 NEFAEK(ub)AGIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NEFAEKAGIIK 11 1 A5PLN9-2;A5PLN9-4;A5PLN9;A5PLN9-5;A5PLN9-7 A5PLN9-2 TRAPPC13 Trafficking protein particle complex subunit 13 1 18794800.0 6359200.0 8538700.0 3896900.0 True False 8336972.782580409 7264759.243591907 3493686.169704329 1.0 0.8713905434321645 0.4190593229480335 22.99109219467612 -6.947833109057854 0.5821553711445121 1.0053643909241867 0.26262979049449114 0.99902001163817 0.007799262603878624 0.08436789222222404 0.039655986564911386 0.008152658347247006 0.03780820801984275 1.1276306995234375e-07 6.947833109057854 -0.7427346004296955 down NEFAEK(ub)AGIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NEFAEKAGIIK 11 1 A5PLN9-2;A5PLN9-4;A5PLN9;A5PLN9-5;A5PLN9-7 A5PLN9-2 TRAPPC13 Trafficking protein particle complex subunit 13 1 23557800.0 11898000.0 6975200.0 4684600.0 True False 11520304.502635919 9760433.735187458 3457562.72501243 1.0 0.8472374782241398 0.3001277200807772 23.457675514553994 -6.9474160012269595 0.5865258804324108 1.0063923855974237 0.1136067779514158 0.9989825938177804 0.009583716950509108 0.08454022362033455 0.0403865428355884 0.009971719063099266 0.04578725092143071 1.1287142259144823e-07 6.9474160012269595 -0.8927856076460079 down NEFAEK(ub)AGIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NEFAEKAGIIK 11 1 A5PLN9-2;A5PLN9-4;A5PLN9;A5PLN9-5;A5PLN9-7 A5PLN9-2 TRAPPC13 Trafficking protein particle complex subunit 13 1 63179000.0 16715000.0 13045000.0 33419000.0 True False 25357877.030184407 10717017.828949787 26813720.00193198 1.0 0.42263072007932406 1.057411863383304 24.59593063184065 -6.667327950185162 1.9471342223179813 0.6306166083217344 1.0548015572545357 0.26713887686256976 0.2454073694187701 0.4672840228349478 3.4130025689682744 0.10156564467354882 0.27227833429535747 2.1511567113795359e-07 6.667327950185162 0.42418494893280134 NEFAEK(ub)AGIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEFAEKAGIIK 11 1 A5PLN9-2;A5PLN9-4;A5PLN9;A5PLN9-5;A5PLN9-7 A5PLN9-2 TRAPPC13 Trafficking protein particle complex subunit 13 1 18775000.0 6359200.0 7247700.0 5168100.0 True False 8710368.090918276 6927472.649061145 3947501.220360561 1.0 0.7953134215170495 0.45319568348395733 23.054302256199012 -6.963396687273407 0.3845774145370467 1.022323637970222 0.21399888918552637 0.9998761850349668 0.002509958887976935 0.07850931387275382 0.016804919818923805 0.004433609275391763 0.02884695472932356 1.0879359119471243e-07 6.963396687273407 -0.8083247487846957 down NEFAEK(ub)AGIIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NEFAEKAGIIK 11 1 A5PLN9-2;A5PLN9-4;A5PLN9;A5PLN9-5;A5PLN9-7 A5PLN9-2 TRAPPC13 Trafficking protein particle complex subunit 13 1 22803100.0 11898000.0 6740600.0 4164500.0 True False 9893714.170770723 6704287.049895654 5035277.695527568 1.0 0.6776309618588252 0.5089370491825437 23.23808078998827 -13.99999999999857 0.08166941910017797 2.7212486030062926 0.020376584735757534 0.9998796929644542 0.0022345035540213 12.242086342247667 0.08088987134402932 3.7784131242566517 0.44279572528646427 1.0000000000032925e-14 13.99999999999857 -2.7008720182705352 NEFAEK(ub)AGIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NEFAEKAGIIK 11 1 A5PLN9-2;A5PLN9-4;A5PLN9;A5PLN9-5;A5PLN9-7 A5PLN9-2 TRAPPC13 Trafficking protein particle complex subunit 13 1 56567000.0 16715000.0 18113000.0 21739000.0 True False 21637897.00190847 17104995.627393335 17782725.06097645 1.0 0.7905110014103806 0.821832410950473 24.367056953933098 -10.585098675572869 9.542742915216733 1.000021287295982 0.8061717062026803 0.9807918104269499 0.012786911899661267 5.791735040468207e-06 2.518282939342907e-07 0.012382231126068146 0.004126958069734129 2.5995688508730468e-11 10.585098675572869 -0.19384958109330164 NEFTITHVLIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEFTITHVLIPK 12 0 C9JK83;O95630-2;O95630 C9JK83 STAMBP STAM-binding protein 0 3077240.0 845740.0 1055500.0 1176000.0 False True 1158432.9332641244 1008864.5199282598 898253.0204802566 1.0 0.8708872917533304 0.7754035600051898 20.14374309203529 -6.974432827004245 0.10882480149876927 1.204438807537761 0.4394169909849499 0.9999996319246249 5.553645318453804e-05 0.07488883460924146 0.003213795792867965 0.007693447337983033 0.014729456288702255 1.0606379761937725e-07 6.974432827004245 -0.7650218165528111 NEGEIQDSSMK(ub)PADR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NEGEIQDSSMKPADR 15 1 Q8NCD3;F8WCV1 Q8NCD3 HJURP Holliday junction recognition protein 1 4671520.0 709820.0 1241400.0 2720300.0 True False 687287.1526358232 1737097.4938154777 2007771.8227492874 1.0 2.527469758678762 2.9212998017630003 19.390553465952717 -10.059104674384017 0.32392618981380844 1.413528625143214e-14 3.02871909476766 0.998876547118357 0.02777399921836336 1.4575731262899991 0.14628378786082444 1.4702921518905387 0.12761100930694683 8.727609887196286e-11 10.059104674384017 3.028719094767646 NEGEIQDSSMK(ub)PADR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NEGEIQDSSMKPADR 15 1 Q8NCD3;F8WCV1 Q8NCD3 HJURP Holliday junction recognition protein 1 8612200.0 1821100.0 2160400.0 4630700.0 True False 2762741.840243427 1774859.7407177556 3715440.1152920844 1.0 0.6424269234512956 1.3448379653759883 21.39766932756531 -6.768320979779104 1.5806905389753028 0.7944553783447887 1.34855340476769 0.7240780802147581 0.1506373261519905 0.26920066257313946 1.3271515826903615 0.0751241241848797 0.1791173059030709 1.7048219179324912e-07 6.768320979779104 0.5540980264229012 NEGEIQDSSMK(ub)PADR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NEGEIQDSSMKPADR 15 1 Q8NCD3;F8WCV1 Q8NCD3 HJURP Holliday junction recognition protein 1 3741220.0 709820.0 1361600.0 1669800.0 True False 590246.780357747 1354264.7905435618 2018947.4597171207 1.0 2.294404367140716 3.4205141423955623 19.170958741386993 -6.9727558892285995 0.18060633855602107 0.13642167022951393 5.608967377606881 0.9999966655656877 0.0018058866719303057 0.07541817907624897 0.005699613336724783 0.0431332420403897 0.1261421576321519 1.0647413260632123e-07 6.9727558892285995 5.472545707377367 NEGEIQDSSMK(ub)PADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NEGEIQDSSMKPADR 15 1 Q8NCD3;F8WCV1 Q8NCD3 HJURP Holliday junction recognition protein 1 23227400.0 1821100.0 2143300.0 19263000.0 True False 2357449.8492477154 2024023.470887878 15757331.655071044 1.0 0.8585648053271475 6.6840580554022635 21.16879564965776 -6.901335186701986 0.9527730705440712 0.7665903640277131 7.312430416202835 0.9872193786470493 0.30675840782391994 0.11042965305599227 0.1719222554221671 0.24085108330352137 0.6309681275991701 1.2550609389071767e-07 6.901335186701986 6.545840052175122 up NEGGNSESSLK(ub)NR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NEGGNSESSLKNR 13 1 Q8IWI9-3;Q8IWI9;H3BP52;H3BTF4 Q8IWI9-3 MGA MAX gene-associated protein 1 7735610.0 2872630.0 3641880.0 1221100.0 True False 3766045.7485884917 3098525.6999370544 1094752.2856183003 1.0 0.8227530696084553 0.2906901186818062 21.844619094730607 -6.95143733179311 0.5428382646896363 1.007690412358581 0.08106244373843538 0.999309284104844 0.007921478064389838 0.08291373574881322 0.033613577877206355 0.00867915836952862 0.044082777180914724 1.1183111839921606e-07 6.95143733179311 -0.9266279686201456 down NEGGNSESSLK(ub)NR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NEGGNSESSLKNR 13 1 Q8IWI9-3;Q8IWI9;H3BP52;H3BTF4 Q8IWI9-3 MGA MAX gene-associated protein 1 10202070.0 3920620.0 4645750.0 1635700.0 True False 3796162.064138885 6500822.202266194 1207261.1000518368 1.0 1.7124722528780734 0.31802148582022927 21.856110153922018 -6.767820130297313 1.5828471120052283 1.409791993709749 0.3108251051970199 0.7221384293051913 0.3001071996595408 0.26996746744534095 1.334525885674336 0.1494786506625648 0.35653045160876745 1.706789135465743e-07 6.767820130297313 -1.098966888512729 NEGNIFPNPEATFVK(ub)EITYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NEGNIFPNPEATFVKEITYR 20 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 1 5978600.0 0.0 3920600.0 2058000.0 True False 0.0 3335661.7623791057 1845057.9017299674 0.0 NEGNIFPNPEATFVK(ub)EITYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEGNIFPNPEATFVKEITYR 20 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 1 8508700.0 0.0 0.0 8508700.0 True False 0.0 0.0 6499120.302177177 0.0 NEGSESAPEGQAQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NEGSESAPEGQAQQR 15 0 P67809;H0Y449;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 0 15416000.0 4088000.0 0.0 11328000.0 False True 3958228.677658071 0.0 8360856.9672844745 1.0 0.0 2.1122723440605427 21.916423532541614 -6.777959136484422 1.5437357700472767 0.4322747920455982 2.127971083510916 0.7601290747586926 0.42253967092559186 0.25375957738899385 1.1943187041086631 0.2156094300189956 0.5096408598901035 1.667404094092498e-07 6.777959136484422 1.6956962914653178 NEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NEHTYVHSSATIPLDDPTLLFANAGMNQFKPIFLNTIDPSHPMAK 45 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 159136000.0 36669000.0 66830000.0 55637000.0 False True 55629553.862987325 54903664.35482677 44640322.563436635 1.0 0.9869513692317508 0.8024569579217444 25.729348199746678 -6.921164337893957 0.8160496803730968 1.0039026725884816 0.7718944970554333 0.994497991973041 0.006690965277742197 0.09749223324868693 0.10210209154268886 0.005800722988032217 0.017573993097508855 1.1990454960984122e-07 6.921164337893957 -0.2320081755330483 NEILQGK(ub)LSQLEEHLSQLQDNPPQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NEILQGKLSQLEEHLSQLQDNPPQEK 26 1 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4;Q14980-5;F5H4J1;F5H6Y5 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 1 20050700.0 5062100.0 9966600.0 5022000.0 True False 4209360.439053497 9912907.947584802 6072076.980895534 1.0 2.354967718044546 1.4425177099495146 22.005169619362125 -10.431792337244573 5.802151921257431 0.9995462588180833 1.898742713997031 0.5639992799480744 0.3725061559385373 0.0021874370470190757 0.00021421747299212406 0.3608462467781439 0.12022584485914113 3.7000505953871106e-11 10.431792337244573 0.8991964551789476 NEILQGK(ub)LSQLEEHLSQLQDNPPQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NEILQGKLSQLEEHLSQLQDNPPQEK 26 1 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4;Q14980-5;F5H4J1;F5H6Y5 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 1 32869800.0 8759300.0 17428000.0 6682500.0 True False 11339086.521616323 16458116.479556745 5466353.568240266 1.0 1.4514499424783234 0.48208059421889554 23.434801085460233 -6.780058708724765 1.5355157619525814 1.2556049624473045 0.4743720325867381 0.7676239994420866 0.19091909041365815 0.2504919956462528 1.1665581037622852 0.09792610199148007 0.2310653101859862 1.659362576598017e-07 6.780058708724765 -0.7812329298605664 down NEK(ub)DNALLSAIEESR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NEKDNALLSAIEESR 15 1 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 52217700.0 9416700.0 21569000.0 21232000.0 True False 12345384.89145252 18350989.27530351 19035116.31172531 1.0 1.4864655445460468 1.5418811547062021 23.55746848022514 -11.729853921176746 0.3562813681008852 7.500548137966391e-15 1.549767820192234 0.9995817994808673 0.004978274523485545 4.54113600994348 0.18454329698233893 3.445036508032584 0.016171863407709968 1.86271357163023e-12 11.729853921176746 1.5497678201922265 NEK(ub)DNALLSAIEESR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NEKDNALLSAIEESR 15 1 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 69648100.0 14391000.0 17397100.0 37860000.0 True False 13934165.582235137 24343852.754677977 27943330.224345896 1.0 1.7470621122598324 2.0053823861524394 23.732123276526636 -10.677134837466564 0.21930982240260807 5.053856366429173e-17 2.18038706969323 0.9992899750119681 0.011359451543995244 2.475979018337853 0.11400765510956905 1.454891386059808 0.14057982355757323 2.1031253710872553e-11 10.677134837466564 2.18038706969323 NEK(ub)DNALLSAIEESR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NEKDNALLSAIEESR 15 1 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 186775000.0 19874000.0 38661000.0 128240000.0 True False 30150310.984019466 31761642.490228266 102893307.79041131 1.0 1.0534432798077225 3.4126781592716484 24.84566954702641 -6.911782448090493 0.8835019186317592 0.9310064840297163 3.729493732293328 0.9915771493362042 0.10324463963542309 0.103251326325174 0.13245856523745533 0.08527981999579151 0.23842437121681964 1.22522980211595e-07 6.911782448090493 2.7984872482636116 up NEK(ub)DNALLSAIEESR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEKDNALLSAIEESR 15 1 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 48596700.0 9416700.0 13143000.0 26037000.0 True False 12898308.46674897 12562298.801911058 19887596.848847333 1.0 0.9739493232229541 1.5418763553466186 23.62067854174803 -6.89615074199378 0.9852820451700705 0.9738287370725248 1.5970409985964356 0.9845514806843582 0.032539573798722556 0.11429555434120596 0.19383120997693185 0.024937539410374125 0.06371664127713557 1.270133170206578e-07 6.89615074199378 0.6232122615239107 NEK(ub)DNALLSAIEESR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NEKDNALLSAIEESR 15 1 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 51935000.0 14391000.0 15883000.0 21661000.0 True False 11966754.129396675 15797435.126471346 26190214.950851917 1.0 1.3201102784977 2.188581353611578 23.512528551960912 -6.953686498713439 0.5167902260536864 0.9848677673969181 2.5623688974578047 0.9994597314307165 0.011671931418330478 0.08203834782659002 0.030090907221205727 0.01329140537034667 0.07171469050764111 1.1125345354380309e-07 6.953686498713439 1.5775011300608868 up NEK(ub)DNALLSAIEESR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NEKDNALLSAIEESR 15 1 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 264413400.0 19874000.0 43038400.0 201501000.0 True False 25727284.775107946 40643275.20620582 164829885.57485673 1.0 1.5797732081517448 6.406812340116647 24.61679586911886 -6.929360718864221 0.7520197921258113 0.9248267400838356 7.381840241734707 0.9964110989939168 0.1451992590878552 0.09297127146786983 0.07931611282109295 0.1317836738592763 0.4383098300539386 1.1766282767143555e-07 6.929360718864221 6.457013501650872 up NEK(ub)GEVEQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEKGEVEQEK 10 1 P23634-7;P23634-6;P23634-8;P23634;P23634-5;P23634-4;P23634-3;P23634-2 P23634-7 ATP2B4 Plasma membrane calcium-transporting ATPase 4 1 1768090.0 850470.0 563170.0 354450.0 True False 1164911.7420875682 538287.2872458525 270736.21012689406 1.0 0.4620841801124095 0.2324092035004506 20.151789224567743 -10.688798255397426 0.17732628646181472 1.87997760588032 1.0647893671717085e-14 0.9995158698239612 0.007077899610631142 2.5765739157440675 0.0950019329295483 1.1304829441771247 0.16565066519026317 2.0473955009091516e-11 10.688798255397426 -1.8799776058803093 NEK(ub)IAVHCTVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NEKIAVHCTVR 11 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 60693500.0 23306000.0 33828000.0 3559500.0 True False 30554391.69562507 28780994.26051125 3191197.0851349924 1.0 0.9419593277202195 0.10444315556745068 24.86487642304893 -6.959843399543121 0.8561906719770088 1.0149979544786598 4.985996578285885e-20 0.9943317836833885 0.03080585219328242 0.08866673430999636 0.10774847270277112 0.02668451836932029 0.07127680503796409 1.0968736419875826e-07 6.959843399543121 -1.0149979544786598 down NEK(ub)IAVHCTVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NEKIAVHCTVR 11 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 62972700.0 28588000.0 31121000.0 3263700.0 True False 27680489.588280067 43547777.59387103 2408839.0610987227 1.0 1.573230034641771 0.0870229933403572 24.7223661245394 -6.802140830911933 1.4472113408559997 1.3154210404629685 0.06541914893804544 0.838335655016017 0.2460712094431645 0.217715156871695 0.9000033801678913 0.13375094988044556 0.3106509539788201 1.5770997724922973e-07 6.802140830911933 -1.2500018915249231 down NEK(ub)IAVHCTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NEKIAVHCTVR 11 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 31814300.0 6369000.0 4105300.0 21340000.0 True False 9662238.636269484 3372677.140144696 17122139.646345727 1.0 0.34905752870608675 1.7720675602105036 23.203926053962416 -6.782278997561059 1.5265844105893953 0.6325258780706321 1.7842444742139476 0.775546181894716 0.27556219166874985 0.24702402761457504 1.1371405500979785 0.14214123060462286 0.33481771213145967 1.6509008929653476e-07 6.782278997561059 1.1517185961433154 NEK(ub)IAVHCTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEKIAVHCTVR 11 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 46513700.0 23306000.0 20501000.0 2706700.0 True False 31922858.020968247 19595198.03225887 2067433.206236318 1.0 0.6138296896658794 0.06476341200021447 24.92808648457182 -7.592669755827593 0.5656604896981287 1.0065695976792917 6.866710255832968e-20 0.9939170477567314 0.029928704703076545 0.11752765776237323 0.10112598755281198 0.030109961040776397 0.07382494446674932 2.5546431540228254e-08 7.592669755827593 -1.0065695976792917 down NEK(ub)IAVHCTVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NEKIAVHCTVR 11 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 72598600.0 28588000.0 40424000.0 3586600.0 True False 23772188.66313616 40206227.888464265 4336541.477435269 1.0 1.6913136799563007 0.18242079174476689 24.502771399973675 -6.7821103816849355 1.5274649323762188 1.3903587326885465 0.169624155408681 0.7748644672250536 0.2926247632777939 0.24729828501728218 1.1397441197655458 0.15086336313426277 0.3553788229429007 1.65154198364828e-07 6.7821103816849355 -1.2207345772798655 NEK(ub)IAVHCTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NEKIAVHCTVR 11 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 32137500.0 6369000.0 9254500.0 16514000.0 True False 8244796.051759197 8739478.939640682 13508621.44794908 1.0 1.0599994086907625 1.638442159532465 22.975052376054865 -6.9267982139924635 0.7726086645984888 0.9900818484188816 1.7480629096528455 0.995871077581661 0.018497350994459795 0.09433399227873734 0.08607273148425386 0.016541659928115803 0.0532898366796131 1.1835913593935906e-07 6.9267982139924635 0.7579810612339639 NELESYAYSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NELESYAYSLK 11 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 78254800.0 5467800.0 44465000.0 28322000.0 False True 7168338.750250527 37830995.32321251 25391511.123807643 1.0 5.277512216047317 3.542175113155783 22.77320738497847 -9.2225778835738 11.614134409185919 0.9999993707515529 4.409843664601552 0.837345926369275 0.7084484056340833 0.0 0.0 0.6859522191669543 0.22865073972231803 5.989935093427412e-10 9.2225778835738 3.409844293849999 NELESYAYSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NELESYAYSLK 11 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 70430900.0 23433000.0 8309900.0 38688000.0 False True 22689132.241575725 11628086.405556027 28554452.184878312 1.0 0.5124958628540514 1.2585079006483524 24.435498097606313 -6.7304553190288114 1.722364972347191 0.7067571391059229 1.2580349049321315 0.5610377429246972 0.20492696166707938 0.3353790764805036 1.9494938105691453 0.09429507509477435 0.23379531635297848 1.8601359273959652e-07 6.7304553190288114 0.5512777658262087 NELESYAYSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NELESYAYSLK 11 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 78657800.0 5467800.0 33297000.0 39893000.0 False True 7489393.421739046 31825828.441545516 30471095.022124894 1.0 4.249453413565703 4.068566478785604 22.83641744650136 -10.14087407765539 4.357946588934404 0.9994308751007196 4.159009946356502 0.9975469464488963 0.07384678249520264 6451471.214697781 41.53915567420624 36870.761129692735 0.02527971776799327 7.2297939886023e-11 10.14087407765539 3.159579071255782 NELESYAYSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NELESYAYSLK 11 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 32127900.0 23433000.0 4032500.0 4662400.0 False True 19485577.757914845 4010776.122111423 5637286.283498075 1.0 0.20583306135135182 0.2893055753098348 24.21590337304059 -10.453092259796653 6.078003434065956 1.0003567462142853 0.24756931853721234 0.9908541306274267 0.034077511124272 0.00016481056648371716 1.4829859121009376e-05 0.033010223477175325 0.010998469422041902 3.5229602272321106e-11 10.453092259796653 -0.752787427677073 NELESYAYSLK(ub)NQIGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NELESYAYSLKNQIGDK 17 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 19888200.0 3979900.0 8185400.0 7722900.0 True False 3853560.2529871184 11453872.906297106 5700040.807966213 1.0 2.972283331347562 1.4791622379714395 21.877760517960493 -6.5754206489129245 2.2846579910116174 2.3467779892081584 1.4825915211948852 0.0 0.8578170335434406 0.7134126016421266 6.997378346522698 0.3161601949605735 0.9602142937794154 2.6581491826159667e-07 6.5754206489129245 -0.8641864680132731 NELESYAYSLK(ub)NQIGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NELESYAYSLKNQIGDK 17 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 19381000.0 3979900.0 7384900.0 8016200.0 True False 3309463.1894646534 7345116.077912112 9692350.357278924 1.0 2.219428244826701 2.928677493115366 21.65816579339477 -8.800722195578363 0.197106336899073 7.893844382480025e-16 3.728928669194756 0.9996381149567695 0.015152206181930628 0.3295204717066347 0.059875388057739905 0.5857644759726123 0.3769596996927256 1.5822598371202288e-09 8.800722195578363 3.728928669194755 NELK(ub)QCIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NELKQCIGR 9 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 4460600.0 1404200.0 2216100.0 840300.0 True False 1840919.798292145 1885466.5182901402 753353.8167267691 1.0 1.024198077525877 0.40922685356834626 20.811995344775383 -6.897737487787955 0.9754323186227621 1.027179568028582 0.34755478601142087 0.9854075134359409 0.03435151176814198 0.11309090353113246 0.18694849455101473 0.02652036615162362 0.06825262905842581 1.2655010569315315e-07 6.897737487787955 -0.6796247820171611 down NELK(ub)QCIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NELKQCIGR 9 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 3981930.0 932230.0 1972100.0 1077600.0 True False 902636.8689269039 2759569.814365637 795344.2326929513 1.0 3.057231439755325 0.8811342191666656 19.783786182226837 -6.658914849074383 1.9771268323471927 2.3254569384249755 0.8903146531048464 0.23077667485301145 0.8761630836449825 0.4870701297469113 3.6590854899747813 0.3582035528814989 0.9709189271241574 2.193234914739315e-07 6.658914849074383 -1.4351422853201292 NELK(ub)QCIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NELKQCIGR 9 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 4277700.0 1404200.0 1844400.0 1029100.0 True False 1923370.687078161 1762908.3093848228 786047.774979789 1.0 0.916572307786857 0.4086824137753151 20.875205406298274 -6.935528114153883 0.6999279234370127 1.006373281490294 0.2880393134035441 0.9975175528152602 0.01301978971513216 0.08986721411536999 0.06435119833501542 0.012279453426246914 0.0446415014548777 1.1600371184457796e-07 6.935528114153883 -0.7183339680867498 down NELNAK(ub)VR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NELNAKVR 8 1 P62195;J3QQM1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 4985700.0 1201200.0 1523000.0 2261500.0 True False 1574784.8324373467 1295774.3366075042 2027501.673839807 1.0 0.8228262743691729 1.287478538069087 20.586723291662747 -6.803340479276712 1.4420402986962302 0.9026570485315819 1.2944499239244065 0.841817779552329 0.07615046140046738 0.21601260165042704 0.886407490048907 0.041535313421032276 0.09641458094830298 1.5727493730151506e-07 6.803340479276712 0.3917928753928246 NELNAK(ub)VR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NELNAKVR 8 1 P62195;J3QQM1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 6631000.0 2102900.0 2337300.0 2190800.0 True False 2036144.590569262 3270596.0788584785 1616963.7574087947 1.0 1.606269070480938 0.7941301245982373 20.957408582943337 -6.706833115102027 1.8062253719572219 1.3739099983273708 0.7961866880465489 0.45020217924869954 0.25560747003455336 0.3814609664060478 2.4238490853476247 0.11269492808969288 0.28743173046279946 1.964114875742291e-07 6.706833115102027 -0.5777233102808219 NELNAK(ub)VR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NELNAKVR 8 1 P62195;J3QQM1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 6111500.0 1099100.0 1338300.0 3674100.0 True False 1667415.0549731203 1099469.9088143748 2947912.5245847628 1.0 0.6593858592887053 1.7679536452501832 20.669181835747185 -6.824214383510476 1.353485799298258 0.817150225221829 1.7944247405135927 0.8938144435634493 0.15108367348032722 0.1880610255438187 0.6757593337494106 0.08768997841531899 0.20192609286859586 1.4989447193550109e-07 6.824214383510476 0.9772745152917637 NELNAK(ub)VR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NELNAKVR 8 1 P62195;J3QQM1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 4197940.0 1201200.0 991840.0 2004900.0 True False 1645316.1012094324 948017.229223729 1531383.9122116223 1.0 0.5761915467349188 0.9307536169408047 20.649933353185638 -10.037369360722737 7.103865046165883 1.0000000357657286 0.7534725818378617 0.39194630457662183 0.14474935902488142 8.197828813895405e-08 1.1171498318576827e-08 0.14015298510376384 0.04671765473979697 9.175519008816443e-11 10.037369360722737 -0.2465274539278669 NELNAK(ub)VR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NELNAKVR 8 1 P62195;J3QQM1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 6558300.0 2102900.0 2732200.0 1723200.0 True False 1748654.524265739 2717481.0963007607 2083513.1528234158 1.0 1.5540411548369355 1.1914950174039005 20.737813858377613 -10.191409020093694 4.987120139875052 0.9999654141572061 1.3727680861209353 0.5849898535797534 0.1480088408231063 5.692164663953172e-05 9.228927080318615e-06 0.1433222174341892 0.04776964796635648 6.435628701983846e-11 10.191409020093694 0.3728026719637292 NELNAK(ub)VR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NELNAKVR 8 1 P62195;J3QQM1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 3439300.0 1099100.0 1085600.0 1254600.0 True False 1422806.616500007 1025185.405680904 1026275.6732830873 1.0 0.720537417940029 0.7213036974818442 20.440308157839635 -10.072868614384099 6.8771729973782625 1.0000001174045468 0.7209205577109364 0.9999943437906537 0.0003128323129641159 5.632482210086057e-10 7.613174042972455e-11 0.0003028987109442316 0.00010096619485537326 8.455346031469121e-11 10.072868614384099 -0.2790795596936103 NELSGALTGLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NELSGALTGLTR 12 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 10361000.0 1557800.0 3198000.0 5605200.0 False True 2042290.88575666 2720870.8657063656 5025227.672875026 1.0 1.3322641180461885 2.4605837042714906 20.96175693483024 -6.948636205089716 0.5736194266201261 0.9861650691878501 2.861883031779046 0.9990898773258045 0.01885832435088685 0.08403801755703778 0.03826454614402717 0.01989773934681436 0.09409641290279132 1.1255474150670749e-07 6.948636205089716 1.8757179625911957 up NELSGALTGLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NELSGALTGLTR 12 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 10553200.0 3040700.0 2503100.0 5009400.0 False True 2944174.642895033 3502600.8834940577 3697287.8612212935 1.0 1.189671574662405 1.2557977394933737 21.48943182121015 -13.999999999999998 0.1469311293838829 0.08691505430691455 1.3311806145280796 0.9995768015018672 0.002230242430614099 11.947586996980597 0.12055502087573551 3.117764285703351 0.06775445743767973 1.0000000000000041e-14 13.999999999999998 1.244265560221165 NELSGALTGLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NELSGALTGLTR 12 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 11477600.0 1557800.0 3176800.0 6743000.0 False True 2133760.7579620834 3036438.4717272357 5150442.276444193 1.0 1.423045418937821 2.4137862022372594 21.024966996353132 -6.956846036595368 0.47781831779948514 0.9757242431421836 2.902261670176366 0.9996347318549703 0.01132352959856573 0.08084769195818176 0.025445303384113053 0.01390792848318896 0.08173464126757395 1.104470100442222e-07 6.956846036595368 1.9265374270341824 up NELVQK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NELVQKAK 8 1 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 1 45078000.0 12379000.0 18554000.0 14145000.0 True False 16228988.878406521 15785815.52292556 12681411.088420985 1.0 0.9726924851078907 0.7814048788519558 23.95206978205491 -6.932653251304795 0.7246797914017025 1.0026418412160276 0.7393420889765094 0.9970345276476774 0.005295932591202034 0.09128338201312236 0.07110072946788883 0.004903372200722238 0.017062741256492854 1.1677415913043833e-07 6.932653251304795 -0.2632997522395182 NELVQK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NELVQKAK 8 1 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 1 50217000.0 15528000.0 21447000.0 13242000.0 True False 15035072.139597451 30010898.94462751 9773522.948515277 1.0 1.9960595244228085 0.6500482909406881 23.841828454317653 -6.708472028297904 1.8004951510279208 1.613303621517343 0.6533295693101666 0.45790585678008966 0.41983536164772317 0.37815892567038756 2.388706295704765 0.18562143942837844 0.4724691131106804 1.9567167905736764e-07 6.708472028297904 -0.9599740522071765 NELVQK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NELVQKAK 8 1 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 1 6272300.0 2957400.0 1576800.0 1738100.0 True False 4486592.014900837 1295407.720405368 1394563.7731637072 1.0 0.28872866445245504 0.3108291925212036 22.09718856884091 -10.150094654390852 5.584196846193532 1.0000125659814154 0.2997789284867495 0.9992534274150975 0.009022502802696803 1.4115424858175761e-06 2.1484739576634697e-07 0.008736157274085091 0.002912000257955293 7.077915045627897e-11 10.150094654390852 -0.7002336374946659 NELVQK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NELVQKAK 8 1 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 1 39488000.0 12379000.0 13448000.0 13661000.0 True False 16955850.8298964 12853822.893410914 10434553.157126518 1.0 0.7580759598773522 0.6153954326331067 24.0152798435778 -12.65723406595667 0.06474672510635426 2.2800070677057427 1.2996100710408616e-16 0.9999584788182168 0.001022901022842069 7.6516699093324645 0.0551626894709639 1.8241922589153359 0.4956591754483684 2.2017395007840254e-13 12.65723406595667 -2.2800070677057427 NELVQK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NELVQKAK 8 1 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 1 42194600.0 15528000.0 16734000.0 9932600.0 True False 12912220.007037127 16643850.620561063 12009460.736846467 1.0 1.2889999249927748 0.9300848909251346 23.62223372975193 -6.69239353462484 1.857735406280851 1.1807797552419184 0.9312841537015765 0.38163682265905985 0.12216858320526179 0.41159681343662746 2.7558705918494297 0.052570356260671275 0.13649413122194123 2.0305162309421886e-07 6.69239353462484 -0.2494956015403419 NENQLIIFADDTYPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NENQLIIFADDTYPR 15 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 4432090.0 867990.0 1560100.0 2004000.0 False True 1137943.2956271179 1327339.161222169 1796645.303725392 1.0 1.1664369976279665 1.578853103339622 20.117997238431087 -6.955651521673554 0.4929120196979337 0.9912082554995579 1.7716567787561641 0.9995733903798589 0.0050257401378086715 0.08129263214312443 0.027161360723695915 0.005975547177898166 0.03401533313515033 1.1075120963519363e-07 6.955651521673554 0.7804485232566062 NENQLIIFADDTYPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NENQLIIFADDTYPR 15 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 5695490.0 867990.0 2326600.0 2500900.0 False True 1188909.359547766 2223803.1189626623 1910238.927652275 1.0 1.8704563986345826 1.6067153583338651 20.18120729995398 -10.114100853490873 5.92558795333363 0.999995841586335 1.7385858784842492 0.9127131167094445 0.10767182882801826 5.915364714059713e-06 8.841648415288724e-07 0.10425338685534716 0.03475093332553778 7.689518506728106e-11 10.114100853490873 0.7385900368979141 NENSFEK(ub)QVSCHENSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NENSFEKQVSCHENSK 16 1 A0A0A0MTP7;Q99590;A0A087WUE7 A0A0A0MTP7 SCAF11 Protein SCAF11 1 18959200.0 3114900.0 2707300.0 13137000.0 True False 4083664.06473451 2303381.3929727445 11777709.259002209 1.0 0.5640477170647222 2.8841033621525156 21.961432759713357 -6.858111650103092 1.1952611535972624 0.7645604295321484 2.9924581775241363 0.9513039724222083 0.22216918953354362 0.14875655413023414 0.4049125283065811 0.14508269968175416 0.33797418758431685 1.3863993621492326e-07 6.858111650103092 2.227897747991988 up NENSFEK(ub)QVSCHENSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NENSFEKQVSCHENSK 16 1 A0A0A0MTP7;Q99590;A0A087WUE7 A0A0A0MTP7 SCAF11 Protein SCAF11 1 18735100.0 3285900.0 4971500.0 10477700.0 True False 3181590.9031107263 6956645.876030015 7733276.045737676 1.0 2.186530603047776 2.430631806929246 21.601316911593827 -10.485287808794586 0.33200524288195266 1.3137905470132953e-14 2.4864913697515223 0.9991011367431948 0.018734216734482216 2.007153165168854 0.15884634117377436 1.7758291585997412 0.07714119458314656 3.271238366767635e-11 10.485287808794586 2.486491369751509 NENSFEK(ub)QVSCHENSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NENSFEKQVSCHENSK 16 1 A0A0A0MTP7;Q99590;A0A087WUE7 A0A0A0MTP7 SCAF11 Protein SCAF11 1 117122900.0 9215900.0 27988000.0 79919000.0 True False 13981194.072538253 22993322.72875789 64122974.62025787 1.0 1.644589339756122 4.5863732587910855 23.736984244450202 -6.941860060825233 0.6420250725050949 0.9677466290517429 5.425062453435154 0.9983975343381857 0.062489762424966844 0.08692820100648689 0.05082144644758971 0.06172337891164916 0.25119151108925336 1.1432466545071285e-07 6.941860060825233 4.457315824383411 NENSFEK(ub)QVSCHENSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NENSFEKQVSCHENSK 16 1 A0A0A0MTP7;Q99590;A0A087WUE7 A0A0A0MTP7 SCAF11 Protein SCAF11 1 40883000.0 3114900.0 1583100.0 36185000.0 True False 4266562.707007378 1513153.4073883712 27638848.253467776 1.0 0.3546539711939957 6.478012899722272 22.02464282123625 -6.880853195720194 1.0749961806069557 0.5952994695534686 6.919192819064148 0.9743685565757786 0.43981101551387614 0.126878501635385 0.2677238699510852 0.3149074174251963 0.7632256640991882 1.315669491932248e-07 6.880853195720194 6.323893349510679 up NENSFEK(ub)QVSCHENSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NENSFEKQVSCHENSK 16 1 A0A0A0MTP7;Q99590;A0A087WUE7 A0A0A0MTP7 SCAF11 Protein SCAF11 1 87457100.0 9215900.0 20831200.0 57410000.0 True False 11930164.222547928 19671925.40790353 46961969.07634467 1.0 1.6489232705383658 3.9364059203465844 23.50811056654265 -6.94778049190665 0.5827010601976098 0.9729244316055013 4.726073566548003 0.9990154003724415 0.03951975534551307 0.08438941368339675 0.03974656319312133 0.04128637045578979 0.19122924369177413 1.1277673264249462e-07 6.94778049190665 3.7531491349425012 NENSNDPELK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NENSNDPELKK 11 1 Q8IXB1;Q8IXB1-2 Q8IXB1 DNAJC10 DnaJ homolog subfamily C member 10 1 1352450.0 319460.0 304550.0 728440.0 True False 437572.9950818889 291093.9739878269 556397.4746927203 1.0 0.6652466611504455 1.2715535029500489 18.73916417905809 -6.756811148130161 1.6243081624774618 0.8047870518320583 1.2734378894359766 0.6778607559333032 0.14074199620690997 0.28831808051305663 1.4984581589825507 0.06838779939092364 0.16487913263857676 1.7506077705483622e-07 6.756811148130161 0.46865083760391824 NENTFLDLTVQQIEHLNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NENTFLDLTVQQIEHLNK 18 0 A0A087WYS1;E7EUC7;Q16851-2;Q16851;C9JVG3;C9JQU9;C9JNZ1;C9JWG0 A0A087WYS1 UGP2 UTP--glucose-1-phosphate uridylyltransferase 0 3637500.0 2612900.0 0.0 1024600.0 False True 2172742.121096559 0.0 1238839.1227848597 1.0 0.0 0.5701731055683825 21.051085523092016 -9.9690861989696 6.138512826209151 1.0000003357189655 0.2850865527841247 0.6770231939497968 0.23277219561700258 1.0696104441549383e-06 1.7945184571790635e-07 0.2253808133773503 0.07512690309036381 1.0737762675792693e-10 9.9690861989696 -0.7149137829348409 NEPFVFSLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEPFVFSLGK 10 0 Q13451;Q13451-2 Q13451 FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5;Peptidyl-prolyl cis-trans isomerase FKBP5, N-terminally processed 0 7410400.0 1897400.0 2220300.0 3292700.0 False True 2598920.0553070046 2122199.804449756 2515032.0752851535 1.0 0.8165698672093495 0.9677219851951384 21.309480825455942 -10.040779582987788 5.533663118980734 1.0000005306814714 0.8921459262225985 0.4043594638074457 0.061707593767914695 4.039846981668305e-07 7.014914929592225e-08 0.05974841455227731 0.019916040249772983 9.103751971488856e-11 10.040779582987788 -0.10785460445887296 NEPIIK(ub)VSDHSNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NEPIIKVSDHSNR 13 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-5;H0Y9T9;E9PKR7;Q9NQW1;Q9NQW1-2;Q9NQW1-5;Q9NQW1-4 D6REX3 SEC31A;SEC31B Protein transport protein Sec31A;Protein transport protein Sec31B 1 6165300.0 1573500.0 1480300.0 3111500.0 True False 1523550.1037903524 2071391.5096625183 2296504.8070008475 1.0 1.3595821394447238 1.5073378954111885 20.539005514902414 -12.077673830382189 0.14653544476159885 3.7002696332370715e-15 1.696063378086503 0.9996142961806525 0.004184209888520766 5.63729687941844 0.10108801524628137 1.8651451234546355 0.14877046346900205 8.362308196436935e-13 12.077673830382189 1.6960633780864993 NEPIIK(ub)VSDHSNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NEPIIKVSDHSNR 13 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-5;H0Y9T9;E9PKR7;Q9NQW1;Q9NQW1-2;Q9NQW1-5;Q9NQW1-4 D6REX3 SEC31A;SEC31B Protein transport protein Sec31A;Protein transport protein Sec31B 1 13971100.0 1878600.0 2427900.0 9664600.0 True False 2849973.544056502 1994622.2757307193 7754387.573855349 1.0 0.6998739619497236 2.7208630024046334 21.442517096308347 -6.869124179439435 1.1387783449638047 0.831140460277111 2.8372384854671053 0.9637981502439157 0.1694208018589415 0.1376942321610516 0.33429066343038566 0.11552479753025474 0.2730897810988085 1.3516860153144975e-07 6.869124179439435 2.0060980251899942 up NEPIIK(ub)VSDHSNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NEPIIKVSDHSNR 13 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-5;H0Y9T9;E9PKR7;Q9NQW1;Q9NQW1-2;Q9NQW1-5;Q9NQW1-4 D6REX3 SEC31A;SEC31B Protein transport protein Sec31A;Protein transport protein Sec31B 1 8498000.0 1878600.0 2470200.0 4149200.0 True False 2431884.7327421634 2332731.1985196876 3394088.1743872017 1.0 0.9592276998627844 1.3956616153266728 21.213643418400796 -6.884026607482903 1.0570378943722054 0.9730834902196912 1.429088939397591 0.976792869866237 0.029985142983018707 0.12412525030481819 0.2512134387187925 0.021765732097794217 0.05321941404603493 1.306090866726028e-07 6.884026607482903 0.45600544917789976 NEPIK(ub)YQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NEPIKYQR 8 1 Q9UHA3;H3BMQ2 Q9UHA3 RSL24D1 Probable ribosome biogenesis protein RLP24 1 10390400.0 1322700.0 2189300.0 6878400.0 True False 2006632.6023227593 1798602.3099210267 5518881.22509018 1.0 0.8963286591870734 2.750319724050057 20.936345064785424 -6.893665549760683 1.0004799350646532 0.9089586528268851 2.9216990688304425 0.9831415115596445 0.11044182569975083 0.11621817046063461 0.20489389794992127 0.08368192425289475 0.21156326834399436 1.2774221731067292e-07 6.893665549760683 2.0127404160035574 up NEQDAYAINSYTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NEQDAYAINSYTR 13 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 24161200.0 1767200.0 11712000.0 10682000.0 False True 2316816.3135891426 9964615.25301842 9576729.10897935 1.0 4.300994944904171 4.133572891734074 21.14371223546087 -10.20445684034029 4.33233222497786 0.9988532292554163 4.21728391842754 0.9979731263852517 0.06834976739869417 12017350.468348972 290.7284101050104 137935.45959831402 0.023397943317359917 6.245154107819791e-11 10.20445684034029 3.218430689172124 NEQDAYAINSYTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NEQDAYAINSYTR 13 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 21063100.0 6163400.0 1665700.0 13234000.0 False True 5967746.240674584 2330822.6965107475 9767618.388510125 1.0 0.3905700079243442 1.636734873533431 22.50875476022835 -6.7737221466899316 1.560102674368828 0.652103772265502 1.6447678482643608 0.7446017090067487 0.25712459377968166 0.260466899886803 1.2515943191477654 0.12986709402661528 0.30810736233844016 1.6837509482276862e-07 6.7737221466899316 0.9926640759988589 NEQDAYAINSYTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEQDAYAINSYTR 13 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 28064200.0 1767200.0 12338000.0 13959000.0 False True 2420581.5967843053 11792866.363690073 10662171.694629181 1.0 4.871914410717103 4.404797470489599 21.206922296983763 -10.181401261105066 5.143150177456525 0.9997757518160468 4.6383559406059245 0.9877885810187691 0.19069969230355482 0.0004903798064090454 7.805103060809019e-05 0.18465422840843443 0.06154806103359047 6.585651408090096e-11 10.181401261105066 3.6385801887898777 NESCDISK(ub)EHTSETTER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NESCDISKEHTSETTER 17 1 P49454 P49454 CENPF Centromere protein F 1 3056000.0 500800.0 1010500.0 1544700.0 True False 685959.2936111247 965852.7687233587 1179873.6740951142 1.0 1.4080321933372735 1.7200345342416092 19.387763440561105 -6.974106698902819 0.12603643509627255 0.48745584338899606 2.6486622803659006 0.999999317707717 0.0002434582633840394 0.07499121137501585 0.0037713647684276593 0.02051401717319644 0.04350872614881304 1.0614347483668768e-07 6.974106698902819 2.1612064369769044 NESCDISK(ub)EHTSETTER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NESCDISKEHTSETTER 17 1 P49454 P49454 CENPF Centromere protein F 1 9131600.0 2480100.0 3702800.0 2948700.0 True False 3210538.3400797667 3496735.924977204 2412066.8562169927 1.0 1.0891431761846913 0.7512966987826298 21.61438379671689 -6.836554354371899 1.298276659183674 1.0474627429397219 0.7409195095617631 0.9183752075285914 0.040843972215609765 0.17285717428781822 0.5674377002803762 0.024681976268752837 0.05682150817547292 1.456953347497614e-07 6.836554354371899 -0.30654323337795875 NETLGGTCLNVGCIPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NETLGGTCLNVGCIPSK 17 0 P09622;P09622-3;F8WDM5;A0A1W2PR83;F2Z2E3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial 0 16629100.0 3567200.0 5971200.0 7090700.0 False True 4676633.744813945 5080320.235555297 6357022.382797216 1.0 1.0863198857915721 1.3593158518874184 22.157039016419503 -6.950258120184817 0.5560008556960937 0.9963520061149312 1.4622414426444788 0.9992213952608235 0.004273329507750541 0.08338221997789601 0.035534432431823804 0.004603212809675683 0.022674168942891707 1.12135178784798e-07 6.950258120184817 0.4658894365295475 NETLGGTCLNVGCIPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NETLGGTCLNVGCIPSK 17 0 P09622;P09622-3;F8WDM5;A0A1W2PR83;F2Z2E3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial 0 16898400.0 3567200.0 6686900.0 6644300.0 False True 4886090.23995529 6391450.647378753 5075053.183653888 1.0 1.3080909957645885 1.038673649977518 22.220249077942395 -10.572670033789745 6.057938313986797 0.9995530424944341 1.1733823228710527 0.3557535787995272 0.109989170838883 0.0006656471131920071 4.695514635341483e-05 0.10676696096853919 0.03549885224351303 2.6750380645509016e-11 10.572670033789745 0.1738292803766186 NETSAPFK(ub)ERPTPSLNNNCTTSEDSLVLYNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NETSAPFKERPTPSLNNNCTTSEDSLVLYNR 31 2 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 26783500.0 9041400.0 9213100.0 8529000.0 True False 11704270.532638669 8700382.886034213 6976809.514930216 1.0 0.7433511436507061 0.5960909306970136 23.480531685655112 -13.591335251670024 0.06562147590928327 2.4789419745953705 1.676058999333878e-07 0.9999451096951193 0.0012365058574771068 10.765545191354134 0.06373661863236038 2.6243619454822866 0.5287318816492834 2.562505158502804e-14 13.591335251670024 -2.4789418069894706 NEVAQLK(ub)QLLLAHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NEVAQLKQLLLAHK 14 1 F5H629;B8ZZU6;K7ELQ4;P15336-6;P15336-8;P17544-4;P15336-2;P15336-4;P17544-2;P17544-3;P17544;P15336-5;P17544-1;P15336 F5H629 ATF2;ATF7 Cyclic AMP-dependent transcription factor ATF-2;Cyclic AMP-dependent transcription factor ATF-7 1 15773000.0 5981100.0 5628200.0 4163700.0 True False 5791233.254388612 7875569.610675274 3073102.061677464 1.0 1.359912347634616 0.5306472605551951 22.465439174971163 -6.788753237110304 1.5013860278387023 1.2014803330604888 0.5221367769645785 0.7972420075753659 0.15288461094292696 0.23721221266339423 1.0563801435012026 0.08015854008712074 0.18783656481246291 1.6264726428933477e-07 6.788753237110304 -0.6793435560959104 NEVLMVNIGSLSTGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NEVLMVNIGSLSTGGR 16 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 6047800.0 3831900.0 2215900.0 0.0 False True 5023658.008172384 1885296.3575105497 0.0 1.0 0.3752835791058205 0.0 22.260306823619914 -8.384050107786612 0.5247936708351988 1.040504086385864 5.0068300451794794e-20 0.9926479107700064 0.03536609341140186 0.17692837540124914 0.18001874864663114 0.06722035834467437 0.06931004613061384 4.129998483748816e-09 8.384050107786612 -1.040504086385864 NEVLMVNIGSLSTGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NEVLMVNIGSLSTGGR 16 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 17399000.0 0.0 8338600.0 9060400.0 False True 0.0 6850511.680220837 7269607.96868561 0.0 NEVLMVNIGSLSTGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEVLMVNIGSLSTGGR 16 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 15326300.0 3831900.0 3784500.0 7709900.0 False True 5248656.983203814 3617288.276332067 5888980.410374779 1.0 0.6891835926614603 1.1219975756122107 22.323516885142805 -6.713971349167845 1.7810141237942094 0.8096960996729395 1.1211055904554525 0.48393590036504874 0.13089832387328396 0.3671594565695523 2.272605115793086 0.05843450777722482 0.14774252585935005 1.9320957750624578e-07 6.713971349167845 0.311409490782513 NEVLMVNIGSLSTGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NEVLMVNIGSLSTGGR 16 0 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 13959400.0 7410500.0 2364900.0 4184000.0 False True 6162159.090813292 2352159.8143041017 5058855.055369761 1.0 0.38171033555604933 0.8209549576400315 22.555004498790787 -9.848689088827806 5.904412425218529 1.000000063503289 0.6013326465975527 0.5234387686623365 0.17932086606320874 1.4973838667050605e-07 2.9358565834920934e-08 0.1736267104312073 0.057875560657235765 1.4168077088098712e-10 9.848689088827806 -0.39866741690573637 NEVSFVIHNLPVLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NEVSFVIHNLPVLAK 15 0 P49903-4;P49903;P49903-3 P49903-4 SEPHS1 Selenide, water dikinase 1 0 11001200.0 2217000.0 4495100.0 4289100.0 False True 2906508.469458543 3824448.601762563 3845305.075952385 1.0 1.315822280220303 1.3229980632634217 21.470855681860268 -11.841983981965885 0.5841945932020759 4.071188367285808e-05 1.322187724951478 0.9999558361763625 0.0010008080140211672 6.397396363021805 0.290574739447827 8.046887104260454 0.001275630015790178 1.4388516462792511e-12 11.841983981965885 1.322147013067805 NEVSFVIHNLPVLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NEVSFVIHNLPVLAK 15 0 P49903-4;P49903;P49903-3 P49903-4 SEPHS1 Selenide, water dikinase 1 0 18616300.0 8239600.0 6045500.0 4331200.0 False True 7978038.408129012 8459499.676866025 3196728.7867851746 1.0 1.0603483267574194 0.40069107508030444 22.92760263823482 -6.884537582714642 1.0541351713524514 1.0402227884257589 0.3496688437764259 0.9771663400765347 0.044994277653780064 0.12368804699683844 0.24862347848463967 0.032733278025283793 0.08015597810430862 1.3045550709530044e-07 6.884537582714642 -0.690553944649333 down NEVSFVIHNLPVLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NEVSFVIHNLPVLAK 15 0 P49903-4;P49903;P49903-3 P49903-4 SEPHS1 Selenide, water dikinase 1 0 33098900.0 8951400.0 12985900.0 11161600.0 False True 13579928.234998088 10668464.68570021 8955504.867696937 1.0 0.7856053803145677 0.6594662882397918 23.694972519693597 -13.999999844377502 0.057048476680890754 2.411039003724295 0.04829053660761822 0.9999613803265052 0.0008735493982901082 12.494341938092154 0.059925768210766936 2.5855088019658488 0.5763051075326561 1.0000003583341082e-14 13.999999844377502 -2.3627484671166767 NEVSFVIHNLPVLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEVSFVIHNLPVLAK 15 0 P49903-4;P49903;P49903-3 P49903-4 SEPHS1 Selenide, water dikinase 1 0 18451700.0 2217000.0 6326100.0 9908600.0 False True 3036684.8121722573 6046591.984384808 7568392.754022678 1.0 1.9911819495219354 2.4923208110652473 21.53406574338316 -9.438638943743944 0.19342478982544056 2.7971629401363476e-21 3.013358332691311 0.9995352700223935 0.013367646499797818 0.870776355846899 0.07567576155468779 0.8079462474409893 0.3001903507697268 3.642177073308225e-10 9.438638943743944 3.013358332691311 NEVSFVIHNLPVLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NEVSFVIHNLPVLAK 15 0 P49903-4;P49903;P49903-3 P49903-4 SEPHS1 Selenide, water dikinase 1 0 15206200.0 8239600.0 4763400.0 2203200.0 False True 6851592.476170997 4737738.618739127 2663878.9335541744 1.0 0.6914799202107254 0.3887970486888735 22.708007913669096 -7.123861366484917 0.23995009937439965 1.1173601126289707 3.0318716894245793e-12 0.9999825438917194 0.0010425177864930978 0.07928902975048562 0.009720715826780468 0.009318557334494966 0.03243869471833622 7.518628619686921e-08 7.123861366484917 -1.117360112625939 down NEVSFVIHNLPVLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NEVSFVIHNLPVLAK 15 0 P49903-4;P49903;P49903-3 P49903-4 SEPHS1 Selenide, water dikinase 1 0 25963300.0 8951400.0 12748400.0 4263500.0 False True 11587763.758473452 12038940.333255766 3487586.747204243 1.0 1.038935603468132 0.3009715092486223 23.466098841786046 -6.894451208641979 0.9957061395272425 1.0355251213340895 0.23168276622183406 0.9835968487242475 0.043426981718379706 0.11560483660869725 0.2013584080120227 0.03302288541290565 0.08375919473605756 1.2751133461043865e-07 6.894451208641979 -0.8038423551122554 down NEVVVELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NEVVVELR 8 0 O00629 O00629 KPNA4 Importin subunit alpha-3 0 7532400.0 1935400.0 3020600.0 2576400.0 False True 2537328.1424402595 2569938.2542065824 2309818.8425739007 1.0 1.0128521460117337 0.9103350898683711 21.274878678737014 -6.875465944449388 1.104710692631642 1.0075753030412928 0.9036712744787418 0.9698434254471421 0.007918835317289378 0.13172521158005146 0.29716529458540764 0.005542313946962451 0.013261972091776352 1.332091495242227e-07 6.875465944449388 -0.10390402856255099 NEVVVELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NEVVVELR 8 0 O00629 O00629 KPNA4 Importin subunit alpha-3 0 4283160.0 963060.0 1188800.0 2131300.0 False True 932488.1874523908 1663494.0395101036 1573048.5923705334 1.0 1.783930415306237 1.6869367500173797 19.83072592418882 -10.08688510120501 4.340296444778496 0.9999213415716075 1.7354335827063758 0.9871224824803962 0.0395974983110477 5145080.212876003 2989304.6030191993 3612.957723261433 0.013555277060945788 8.18681353306138e-11 10.08688510120501 0.7355122411347683 NEVVVELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NEVVVELR 8 0 O00629 O00629 KPNA4 Importin subunit alpha-3 0 6936100.0 1935400.0 1723700.0 3277000.0 False True 2650969.6822183933 1647541.2344863482 2503040.0919335037 1.0 0.621486260494555 0.9441979320709928 21.338088740259906 -10.098692317412516 7.208270522169486 1.0000000691681308 0.7828420962827739 0.37646332518229364 0.13174648823381638 1.464399394756148e-07 1.8195462325951407e-08 0.12756303053096757 0.04252099623757352 7.967236015742541e-11 10.098692317412516 -0.21715797288535688 NFAELK(ub)IK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFAELKIK 8 1 P18124 P18124 RPL7 60S ribosomal protein L7 1 11165400.0 2589700.0 5152700.0 3423000.0 True False 3395121.778690477 4383937.245067291 3068820.7957345345 1.0 1.2912459495806974 0.9038912285845019 21.695031892354393 -6.705522985383008 1.8110829159177217 1.1798646126558705 0.9049131009426207 0.4438430672803556 0.12281900187765347 0.38415304870263617 2.4532900169184306 0.05402399429249766 0.13800076979082262 1.9700489380408988e-07 6.705522985383008 -0.27495151171324983 NFAELK(ub)IK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFAELKIK 8 1 P18124 P18124 RPL7 60S ribosomal protein L7 1 18151100.0 4798000.0 6795900.0 6557200.0 True False 4645690.116292411 9509538.310150314 4839672.608216603 1.0 2.0469592400923196 1.0417553661713028 22.147461493897424 -6.636675666621584 2.0565014905168755 1.686379387082429 1.0459104614021517 0.14193040423421233 0.44833888912940506 0.5418368964316914 4.375430606750336 0.17779179939421233 0.496463016153974 2.3084705229383838e-07 6.636675666621584 -0.6404689256802774 NFAELK(ub)IK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFAELKIK 8 1 P18124 P18124 RPL7 60S ribosomal protein L7 1 19971800.0 6091000.0 6373000.0 7507800.0 True False 9240492.311747124 5235688.357523732 6023880.03921436 1.0 0.566602750252579 0.6519003356083534 23.13953828641956 -10.101924249079472 5.326620382123274 1.0000064296669902 0.6092515429301889 0.9654943707266681 0.03482259340320582 2.658949295562573e-06 4.48329395906911e-07 0.033717385542184494 0.011238943693384056 7.908165525192733e-11 10.101924249079472 -0.39075488673680125 NFAELK(ub)IK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFAELKIK 8 1 P18124 P18124 RPL7 60S ribosomal protein L7 1 13336400.0 2589700.0 4603000.0 6143700.0 True False 3547182.074011048 4399624.239914527 4692684.593473259 1.0 1.2403153117368917 1.3229331045211647 21.758241953877285 -13.50103421230369 0.1544086715940955 5.846665429230758e-07 1.4113790222152323 0.9995523506244512 0.00289810453788387 10.008359873125839 0.12003043080000234 3.057667877411094 0.07812423068417466 3.1547560921835855e-14 13.50103421230369 1.4113784375486893 NFAELK(ub)IK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFAELKIK 8 1 P18124 P18124 RPL7 60S ribosomal protein L7 1 13011600.0 4798000.0 6112000.0 2101600.0 True False 3989749.5874397308 6079073.442862984 2541034.8432994965 1.0 1.5236729297499587 0.6368908092124419 21.9278667693317 -6.746704210998139 1.6620209311063898 1.309148657737904 0.6355633276874474 0.6346214370898274 0.22002546258144828 0.305857639940125 1.661224561220611 0.10462393653473687 0.2548859197765838 1.7918258140975847e-07 6.746704210998139 -0.6735853300504565 NFAELK(ub)IK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFAELKIK 8 1 P18124 P18124 RPL7 60S ribosomal protein L7 1 17730700.0 6091000.0 7429300.0 4210400.0 True False 7884919.571559944 7015852.924120444 3444150.40235223 1.0 0.8897811652291128 0.4368022236745331 22.910664608512008 -6.944253002957263 0.6187355305603001 1.0049623088228132 0.29767517602642735 0.9986695412749649 0.008889254442213808 0.08587890489723492 0.046169164691556616 0.0089625124966614 0.03831753754684654 1.1369647417234712e-07 6.944253002957263 -0.7072871327963859 down NFAFLEFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFAFLEFR 8 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 59861000.0 17928000.0 24112000.0 17821000.0 False True 23503781.61499894 20514583.587839853 15977053.871102877 1.0 0.8728205496407637 0.6797652451343029 24.48638956050335 -6.96505847706152 0.35704712976393455 1.0172069333065379 0.5287933131067332 0.9999143441569195 0.0012184510047511911 0.07794112709658035 0.01478999197919255 0.0026062602882607855 0.016518969470726123 1.0837809748109865e-07 6.96505847706152 -0.4884136201998047 NFAFLEFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFAFLEFR 8 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 58757000.0 26210000.0 11082000.0 21465000.0 False True 25377977.89662863 15507100.391866552 15842672.563803049 1.0 0.6110455472469544 0.6242685145496832 24.59707378481977 -9.942187310162304 5.756632048573769 1.0000003111821198 0.6176570309080802 0.9991037606967266 0.005398253797228804 2.1558882416103033e-08 3.9574656674568286e-09 0.005226841008060395 0.001742278921122142 1.1423855204036537e-10 9.942187310162304 -0.38234328027403963 NFAFLEFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFAFLEFR 8 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 50651000.0 12300000.0 21869000.0 16482000.0 False True 18659999.25044981 17966306.08672311 13224325.475682767 1.0 0.9628245878032403 0.7086991429200613 24.15344559244985 -6.93314175704562 0.7205346589040655 1.0034502478186964 0.6520931517977301 0.9971205167989207 0.006946441393231599 0.09103902383449228 0.06992638949775548 0.006451242700715872 0.02260988662584726 1.1664288236144386e-07 6.93314175704562 -0.3513570960209663 NFAFLEFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFAFLEFR 8 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 73823000.0 17928000.0 21080000.0 34815000.0 False True 24556466.085982915 20148615.897761907 26592414.037432082 1.0 0.8205014445976389 1.0829088332303363 24.549599622026243 -6.722571355699705 1.7500777943121022 0.8910967338670273 1.0825599141841693 0.5246298689672382 0.07551070319371904 0.3503389460960489 2.0983571902715346 0.03424140663458212 0.08569938898303149 1.8942122648436717e-07 6.722571355699705 0.19146318031714205 NFAFLEFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFAFLEFR 8 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 51207000.0 26210000.0 12495000.0 12502000.0 False True 21794776.29987399 12427686.954936702 15116110.39728317 1.0 0.570214017521646 0.6935657512286817 24.377479060254046 -10.459023671262347 9.037025216773092 1.000004755115032 0.6318898843751668 0.9223251650436967 0.05035813441165098 4.8246013830499554e-06 2.8880015503484124e-07 0.04875968271370242 0.016253017993533247 3.4751721946764964e-11 10.459023671262347 -0.36811487073986515 NFAFLEFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFAFLEFR 8 0 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 51505000.0 12300000.0 21033000.0 18172000.0 False True 15922592.46924765 19862495.060507078 14864882.460465696 1.0 1.2474410243726843 0.9335717465089445 23.924571914542298 -6.696548762412976 1.8435027170432974 1.1541697677130802 0.9345730170951921 0.4011017678013524 0.10451547403591072 0.40272674312515583 2.658480658725174 0.04527478359909077 0.11691931352893431 2.0111813708729012e-07 6.696548762412976 -0.21959675061788808 NFAIGYYLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFAIGYYLK 9 0 O94925-3;O94925 O94925-3 GLS Glutaminase kidney isoform, mitochondrial 0 18178200.0 4395300.0 6310700.0 7472200.0 False True 5762280.864145752 5369168.158915928 6699048.42240362 1.0 0.9317782811185302 1.1625688820700588 22.458208551140068 -6.8275273544569695 1.3389245255771627 0.9634798549520244 1.1684713532591353 0.9008378055050345 0.030485056101962754 0.18388227903533721 0.6455732055650757 0.0178812005730467 0.041156105751705495 1.4875536761251556e-07 6.8275273544569695 0.20499149830711094 NFAIGYYLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFAIGYYLK 9 0 O94925-3;O94925 O94925-3 GLS Glutaminase kidney isoform, mitochondrial 0 7305500.0 5015400.0 2290100.0 0.0 False True 4856188.872291164 3204548.872713731 0.0 1.0 0.659889670065863 0.0 22.211393102906825 -7.512483683886147 0.7103498629218203 0.9934807164411679 5.476434381083649e-17 0.9870737675555395 0.04719964577336419 0.11945246681564305 0.14286681171553725 0.04179553676765135 0.07578382967759027 3.072672801082558e-08 7.512483683886147 -0.9934807164411679 down NFAIGYYLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFAIGYYLK 9 0 O94925-3;O94925 O94925-3 GLS Glutaminase kidney isoform, mitochondrial 0 33089600.0 6625400.0 7261200.0 19203000.0 False True 10051216.181620337 5965382.127985452 15407518.633026106 1.0 0.5934985398974659 1.532900930058624 23.260866740047334 -6.789077484318283 1.4999302832495323 0.7725465427160633 1.5426577762529667 0.7984062432097234 0.17271143221186633 0.23669452381304662 1.0520018971569278 0.09063815135766504 0.2123574861457069 1.625258760581192e-07 6.789077484318283 0.7701112335369035 NFAIGYYLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFAIGYYLK 9 0 O94925-3;O94925 O94925-3 GLS Glutaminase kidney isoform, mitochondrial 0 18090400.0 4395300.0 5491700.0 8203400.0 False True 6020361.188516338 5249058.535376627 6265925.8743263045 1.0 0.871884322387343 1.0407890287842487 22.52141861266296 -6.703907844878927 1.8170953279017217 0.9207498169753601 1.0403219412892457 0.4360258798549451 0.05404182996057671 0.38747066883657005 2.489919527361508 0.023703432841263552 0.060662978272744444 1.9773891877118905e-07 6.703907844878927 0.11957212431388564 NFAIGYYLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFAIGYYLK 9 0 O94925-3;O94925 O94925-3 GLS Glutaminase kidney isoform, mitochondrial 0 8136800.0 5015400.0 3121400.0 0.0 False True 4170527.319892718 3104584.3986506085 0.0 1.0 0.7444105170687313 0.0 21.9917983783411 -7.344245096005572 0.791484843373864 0.9893709839595267 6.60591880967276e-23 0.9878705941090276 0.046718120527766166 0.10834497509647575 0.1378191589615619 0.04008644956889873 0.07131826929464695 4.5264205726712006e-08 7.344245096005572 -0.9893709839595267 down NFATSLYSMIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFATSLYSMIK 11 0 P08758;D6RBL5;D6RBE9 P08758 ANXA5 Annexin A5;Annexin 0 16298500.0 3324000.0 5579500.0 7395000.0 False True 4357796.189661791 4747060.348720661 6629836.337848932 1.0 1.0893259212035526 1.5213736598276926 22.055167293763304 -6.940548826083555 0.6544420702019423 0.9951924802507194 1.6397869732794748 0.9982348559090002 0.009564953658803652 0.08751721053141583 0.053477009860731346 0.009349924688691915 0.037096492804252035 1.1467035946336429e-07 6.940548826083555 0.6445944930287554 NFATSLYSMIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFATSLYSMIK 11 0 P08758;D6RBL5;D6RBE9 P08758 ANXA5 Annexin A5;Annexin 0 9990200.0 4465300.0 1181100.0 4343800.0 False True 4323551.49568164 1652719.3893551321 3206028.4687932795 1.0 0.38225967494682717 0.7415266065398917 22.043785441953645 -10.314961434658223 6.001160679138445 1.00003392763215 0.5618931407434379 0.6647370646764315 0.1466701106430685 6.65833507139626e-05 7.600579583283638e-06 0.14202369053521782 0.047337574658916595 4.8421536399019346e-11 10.314961434658223 -0.43814078688871205 NFATSLYSMIK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NFATSLYSMIK 11 0 P08758;D6RBL5;D6RBE9 P08758 ANXA5 Annexin A5;Annexin 0 56245900.0 10828900.0 24654200.0 20762800.0 False True 14832636.970018992 23564895.923463125 15859054.263288679 1.0 1.588719252759609 1.0691999201048585 23.822271769446978 -10.23448558465503 4.748352648828824 0.9999237552851771 1.3289595864331922 0.34835992500379387 0.21209287942252522 0.000171230685953234 2.7604875995673635e-05 0.20540549679210676 0.06845268248725055 5.827931188699832e-11 10.23448558465503 0.32903583114801516 NFATSLYSMIK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NFATSLYSMIK 11 0 P08758;D6RBL5;D6RBE9 P08758 ANXA5 Annexin A5;Annexin 0 34655890.0 18986300.0 6587300.0 9082290.0 False True 15787949.685703848 6551812.9074233165 10981354.847235719 1.0 0.41498820542581605 0.6955529416957447 23.912320490866996 -10.470950612498173 6.2276731506864635 1.0002256052493121 0.5552705735607962 0.7701228884705532 0.11454007394664303 0.0003589632924253421 3.0494323998874855e-05 0.1109580414697778 0.03696764990572623 3.3810328276190876e-11 10.470950612498173 -0.4449550316885159 NFDEAAK(ub)VLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFDEAAKVLK 10 1 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 4955600.0 1981800.0 1443700.0 1530100.0 True False 2714525.016131248 1379912.5603225273 1168721.8933986747 1.0 0.5083440204537825 0.43054379180647295 21.37226834863517 -13.999999999999998 0.2594983518893369 4.589761865947918 0.4019713917744687 0.9995613117324548 0.005280521926491915 14.394981439646966 0.16120055310607725 27.089669985450726 0.034103279726993854 1.0000000000000041e-14 13.999999999999998 -4.1877904741734495 NFDEAAK(ub)VLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFDEAAKVLK 10 1 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 45283300.0 3767000.0 8662300.0 32854000.0 True False 4876455.758671207 8180235.390226318 26874909.11050737 1.0 1.67749607400424 5.511156143007961 22.217401537375725 -6.937087125949053 0.6861249137313352 0.9540378826435598 6.462020574908005 0.997756976118084 0.09406964485927918 0.08912093588715451 0.060851196514296726 0.0896624286903887 0.33440914781126 1.1558803321000339e-07 6.937087125949053 5.507982692264445 NFDLRPGVIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFDLRPGVIVR 11 1 P31153;P31153-2;Q00266 P31153 MAT2A;MAT1A S-adenosylmethionine synthase isoform type-2;S-adenosylmethionine synthase isoform type-1 0 40560000.0 10642000.0 10201000.0 19717000.0 False True 13951765.05727461 8679050.563186562 17676873.978819147 1.0 0.6220754526439797 1.266999114897095 23.73394431517592 -6.7478956591850805 1.6576608352214597 0.7772098391202357 1.2680736661159557 0.6398058166977867 0.15879318170447929 0.3037549549767702 1.6415525937240674 0.07569430230187565 0.18417114085528422 1.7869168364960043e-07 6.7478956591850805 0.49086382699572007 NFDLRPGVIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFDLRPGVIVR 11 1 P31153;P31153-2;Q00266 P31153 MAT2A;MAT1A S-adenosylmethionine synthase isoform type-2;S-adenosylmethionine synthase isoform type-1 0 36433200.0 11691000.0 5500200.0 19242000.0 False True 11319875.604329864 7696458.543164091 14201942.952373572 1.0 0.6799066360959115 1.2546023868797034 23.432354768494186 -6.755534104441274 1.6291265923992475 0.8130390441915815 1.256259879018095 0.6724815829529559 0.1345606815464554 0.29051299730864455 1.5185152362921943 0.06520089512951098 0.1573963460508656 1.755763011563769e-07 6.755534104441274 0.44322083482651353 NFDLRPGVIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFDLRPGVIVR 11 1 P31153;P31153-2;Q00266 P31153 MAT2A;MAT1A S-adenosylmethionine synthase isoform type-2;S-adenosylmethionine synthase isoform type-1 0 40149400.0 5696200.0 29058000.0 5395200.0 False True 8641551.84800099 23872372.868809722 4328836.3551998325 1.0 2.7625099390373973 0.5009327527440806 23.042858983839967 -6.698748456793581 1.8353484931439155 2.095797555535096 0.5078275820430963 0.411605254490621 0.7441509078847284 0.39814772665067116 2.6065361105087743 0.32357219009248 0.8334254663235713 2.0010205244161985e-07 6.698748456793581 -1.5879699734919996 NFDLRPGVIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFDLRPGVIVR 11 1 P31153;P31153-2;Q00266 P31153 MAT2A;MAT1A S-adenosylmethionine synthase isoform type-2;S-adenosylmethionine synthase isoform type-1 0 37354000.0 10642000.0 10706000.0 16006000.0 False True 14576634.989236427 10232973.519992372 12225712.453917522 1.0 0.7020120574843597 0.8387198048757579 23.79715437669881 -10.03512267940063 4.563120261200929 1.0000088615611702 0.7703659311657629 0.7900066169013245 0.05581070421431859 38599526.130325966 0.2090361087346595 3683.3590568782997 0.019105488523006912 9.22310856205004e-11 10.03512267940063 -0.22964293039540729 NFDLRPGVIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFDLRPGVIVR 11 1 P31153;P31153-2;Q00266 P31153 MAT2A;MAT1A S-adenosylmethionine synthase isoform type-2;S-adenosylmethionine synthase isoform type-1 0 23667200.0 11691000.0 6428400.0 5547800.0 False True 9721584.499115877 6393768.933262501 6707819.329871023 1.0 0.65768794519494 0.6899923906932107 23.212760043928462 -10.022054671178237 5.849253043472651 1.0000006211274262 0.673840168293709 0.992696325782842 0.013188234649250128 1.068256692772844e-07 1.78756298317368e-08 0.012769477550292764 0.004256484430172849 9.504851342656052e-11 10.022054671178237 -0.3261604528337172 NFDLRPGVIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFDLRPGVIVR 11 1 P31153;P31153-2;Q00266 P31153 MAT2A;MAT1A S-adenosylmethionine synthase isoform type-2;S-adenosylmethionine synthase isoform type-1 0 20781400.0 5696200.0 6160800.0 8924400.0 False True 7373843.188888491 5817946.064221558 7300250.772076822 1.0 0.7889978014434202 0.9900198017605576 22.813985305932416 -10.597535826095832 8.108535806417265 1.0000602465967285 0.8895088016152092 0.2871482350385509 0.08206688797509745 8.942951276888021e-05 4.438921841528474e-06 0.07950414988431076 0.02648697420021851 2.5261793103505094e-11 10.597535826095832 -0.11055144498151936 NFDQEGLVEHCK(ub)LFHSTDTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFDQEGLVEHCKLFHSTDTK 20 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 109369100.0 28227000.0 42579100.0 38563000.0 True False 37005870.3506568 36226464.252031885 34572870.68241632 1.0 0.9789383119153937 0.9342536833970911 25.14125081208837 -6.958874381622034 0.45102170685796544 1.0014260333671712 0.909991515306102 0.9997260896383875 0.00045364271553147476 0.08010573982601282 0.02263610505670503 0.0005981708605621193 0.0036955991397345993 1.0993237695574676e-07 6.958874381622034 -0.09143451806106917 NFDQEGLVEHCK(ub)LFHSTDTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFDQEGLVEHCKLFHSTDTK 20 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 86386400.0 35154700.0 33319200.0 17912500.0 True False 34038733.29120991 46623730.31733255 13220678.886518626 1.0 1.3697257744127795 0.38840102460371834 25.020674014146902 -6.804640963870384 1.436908206410097 1.2028113802517693 0.3732545527533719 0.845372561355231 0.15912328883875698 0.21420496216434234 0.8726035967102579 0.0870999870430782 0.20201582974236634 1.5680468563746665e-07 6.804640963870384 -0.8295568274983973 down NFDQEGLVEHCK(ub)LFHSTDTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFDQEGLVEHCKLFHSTDTK 20 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 202208000.0 44947000.0 86230000.0 71031000.0 True False 68187885.06585106 70841582.78193498 56991691.7160067 1.0 1.0389174369247727 0.8358037745410074 26.023012102757225 -6.8570664406232 1.2004238285227906 1.0209724101243296 0.8265029616966383 0.9499779873008604 0.019686546515192676 0.14985584700445576 0.4120103988553915 0.012805042874464358 0.029799785967522297 1.389740005312714e-07 6.8570664406232 -0.19446944842769132 NFDQEGLVEHCK(ub)LFHSTDTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFDQEGLVEHCKLFHSTDTK 20 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 102745000.0 28227000.0 24253000.0 50265000.0 True False 38663284.70599284 23181422.266054053 38393442.24017014 1.0 0.5995719826272524 0.993020705098528 25.20446087361126 -10.854237941187245 10.277878598299266 1.006469550082558 0.7962963438628903 0.2632999623289498 0.16062476833408915 0.024006480326828214 0.0003404619983384127 0.15679581125321385 0.05184142106219596 1.3988207269275159e-11 10.854237941187245 -0.21017320621966773 NFDQEGLVEHCK(ub)LFHSTDTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFDQEGLVEHCKLFHSTDTK 20 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 82794800.0 35154700.0 23782300.0 23857800.0 True False 29232690.667271312 23654180.02948306 28846355.673996344 1.0 0.809168759000556 0.986784145268314 24.80107928958118 -10.477083098304849 7.411793381167753 1.000013581520428 0.8979764521449175 0.30551927032625315 0.07251117780389094 1.627552275345338e-05 1.148295774808828e-06 0.07021798797923497 0.023402882004029534 3.3336262075053766e-11 10.477083098304849 -0.10203712937551057 NFDQEGLVEHCK(ub)LFHSTDTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFDQEGLVEHCKLFHSTDTK 20 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 173311000.0 44947000.0 82682000.0 45682000.0 True False 58184777.5378272 78080674.0166807 37368344.736902595 1.0 1.3419433281483073 0.6422357585299456 25.794138424849674 -6.773819706100802 1.5598306125942942 1.195170731866439 0.6377187656430011 0.7449578549814155 0.14427262211194256 0.26029646768994175 1.2503670332809311 0.07288257040540784 0.17289022608543148 1.6833727548392056e-07 6.773819706100802 -0.557451966223438 NFEDVAFDEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFEDVAFDEK 10 0 P07237;H7BZ94;H0Y3Z3 P07237 P4HB Protein disulfide-isomerase 0 21755700.0 1005700.0 10315000.0 10435000.0 False True 1318482.4392126552 8776042.207555076 9355286.299588038 1.0 6.656169203736818 7.095495564715021 20.330446925487184 -9.798742681471893 0.647607144550098 1.3302494398885607e-18 7.034886481937666 0.9994642134492817 0.06424917869259607 1.0744818500426878 0.30974304310671685 2.4802793660218754 0.0718131951150021 1.5894882379502384e-10 9.798742681471893 7.034886481937666 NFEDVAFDEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFEDVAFDEK 10 0 P07237;H7BZ94;H0Y3Z3 P07237 P4HB Protein disulfide-isomerase 0 15697700.0 6126600.0 1698000.0 7873100.0 False True 5932114.436531289 2376020.2549530254 5810898.9220628 1.0 0.4005351347103085 0.9795662211568246 22.500114998442363 -10.898518944329165 10.680739081934513 1.0255504181739343 0.6900506779335858 0.2764354049912352 0.23638845116722348 0.11164277059771606 0.0010607511376673126 0.17767031048054036 0.07629404455053515 1.263225999512701e-11 10.898518944329165 -0.33549974024034857 NFEDVAFDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFEDVAFDEK 10 0 P07237;H7BZ94;H0Y3Z3 P07237 P4HB Protein disulfide-isomerase 0 21782800.0 1005700.0 12255000.0 8522100.0 False True 1377534.468020586 11713533.57813437 6509355.498158843 1.0 8.503259882103597 4.725366696277517 20.393656987010075 -9.515175656312346 10.149762553133149 0.9999999999999925 6.614313289190557 0.7464916449151053 1.5423184346685757 0.0 8.432000914260499e-18 1.4933434030050208 0.4977811343350071 3.053685758649928e-10 9.515175656312346 5.614313289190564 NFEK(ub)SLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFEKSLLK 8 1 O15247;A6PVS0 O15247 CLIC2 Chloride intracellular channel protein 2 1 4522100.0 1765500.0 2042100.0 714500.0 True False 2314587.597126318 1737426.640043454 640570.3939679597 1.0 0.7506419900463306 0.2767535757831164 21.14232373275256 -6.983508068907181 0.42620950796999657 1.0198248573839772 6.697963615252754e-11 0.9998073296084528 0.0041637447570666945 0.07630179904167102 0.01986946037124847 0.006077778266852114 0.037861533129422364 1.0387043037973245e-07 6.983508068907181 -1.0198248573169977 down NFEK(ub)SLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFEKSLLK 8 1 O15247;A6PVS0 O15247 CLIC2 Chloride intracellular channel protein 2 1 7042600.0 2655500.0 1511100.0 2876000.0 True False 2571202.6060472107 2114490.1102823983 2122689.3218494104 1.0 0.8223739760178096 0.8255628385165206 21.294011865696817 -10.360344550181527 5.948202847159369 1.0000275923658335 0.8239684072671835 0.9997539330559273 0.001301847663623714 4.764376322155168e-07 5.123503972508714e-08 0.001260705985259908 0.0004201695267093744 4.36169657075022e-11 10.360344550181527 -0.17605918509865004 NFEK(ub)SLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFEKSLLK 8 1 O15247;A6PVS0 O15247 CLIC2 Chloride intracellular channel protein 2 1 6325600.0 1765500.0 1649300.0 2910800.0 True False 2418253.0608435315 1576428.4724942483 2223328.9898077636 1.0 0.6518873057662381 0.9193946761850579 21.20553379427545 -9.957962860818972 7.010575471528204 1.000000010613576 0.7856409909756475 0.4612509247132992 0.10920942665996818 1.8038493555151257e-08 2.6970779060024958e-09 0.1057415774027422 0.0352471908919095 1.1016335129421605e-10 9.957962860818972 -0.21435901963792847 NFEK(ub)SLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFEKSLLK 8 1 O15247;A6PVS0 O15247 CLIC2 Chloride intracellular channel protein 2 1 6332000.0 2655500.0 2092400.0 1584100.0 True False 2208165.9085965445 2081127.8258911187 1915327.9859491484 1.0 0.9424689593246334 0.8673840939635208 21.074417141131093 -6.967467455602749 0.31283837357324806 1.0111864960529404 0.7962700392525777 0.9999553259822224 0.00036287499446796827 0.07713351868075187 0.011958280803492722 0.0011730694848911215 0.006648019406032485 1.0777860159041108e-07 6.967467455602749 -0.21491645680036275 NFEVVDLVDVNTPDLMAPVSAKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFEVVDLVDVNTPDLMAPVSAKK 23 1 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 45272000.0 9883000.0 12758000.0 22631000.0 True False 14993233.544080928 10481235.22129103 18157972.930480324 1.0 0.6990643606314558 1.2110778423543453 23.83780822260931 -6.747399224751611 1.6594343046832267 0.8225040577571189 1.2119025612522938 0.6378146394569455 0.12644137762136598 0.3045547299048009 1.6492266104922493 0.06021253161943579 0.14658319414039367 1.7889605977788644e-07 6.747399224751611 0.3893985034951749 NFEVVDLVDVNTPDLMAPVSAKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFEVVDLVDVNTPDLMAPVSAKK 23 1 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 40871000.0 9883000.0 12804000.0 18184000.0 True False 12793738.323054835 12091446.144379409 14874698.583596101 1.0 0.9451065700312263 1.1626545899247673 23.60893454470176 -6.839830315051572 1.2830642859075059 0.9707956375439589 1.169790918160834 0.9241746226837748 0.025436537744991557 0.16900255988621285 0.54050220603546 0.015545042157906615 0.03581350998015235 1.4460046346908118e-07 6.839830315051572 0.198995280616875 NFGASLLLPGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFGASLLLPGLK 12 0 D6RJC7;D6RH20;G5EA06;Q92552;Q92552-2 D6RJC7 MRPS27 28S ribosomal protein S27, mitochondrial 0 7054300.0 3829200.0 0.0 3225100.0 False True 3707644.1419981043 0.0 2380349.559073897 1.0 0.0 0.6420113333182756 21.822071350717096 -10.266108948799426 7.366252260461832 1.0000026658734837 0.3210056666591379 0.5986145519709781 0.2621000292856114 1.1475095273591648e-05 1.1432727893320579e-06 0.2537782599294082 0.0845924207053041 5.418649390078646e-11 10.266108948799426 -0.6789969992143459 NFGASLLLPGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFGASLLLPGLK 12 0 D6RJC7;D6RH20;G5EA06;Q92552;Q92552-2 D6RJC7 MRPS27 28S ribosomal protein S27, mitochondrial 0 12669200.0 2058700.0 4398100.0 6212400.0 False True 2819857.0242756084 4203777.399428215 4745159.068394175 1.0 1.4907767887657783 1.6827658379641275 21.427190584573157 -11.331360370004056 0.17199741024203025 2.1622436841086277e-21 1.8785898643509074 0.9995101350015163 0.006363138514510536 3.8098847624942347 0.10341734449788718 1.6006836978157175 0.1497891842227664 4.662723150929049e-12 11.331360370004056 1.8785898643509074 NFGASLLLPGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFGASLLLPGLK 12 0 D6RJC7;D6RH20;G5EA06;Q92552;Q92552-2 D6RJC7 MRPS27 28S ribosomal protein S27, mitochondrial 0 7246600.0 3829200.0 1586900.0 1830500.0 False True 3184149.4623226803 1578351.0547250109 2213249.0867242673 1.0 0.4956900024327632 0.695083290816949 21.602476626151372 -10.174172791144395 5.361144355164777 1.0000151238141723 0.5953866466247525 0.845924520548262 0.08140196911317657 1.471539001152989e-05 2.2666689330252917e-06 0.0788200616766658 0.0262723725602659 6.696181379101846e-11 10.174172791144395 -0.40462847718941986 NFGEEVDDESLKELFSQFGK(ub)TLSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFGEEVDDESLKELFSQFGKTLSVK 25 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 224441000.0 44865000.0 94280000.0 85296000.0 True False 68063485.07084796 77454997.38699782 68437208.21343519 1.0 1.1379816550147872 1.0054908023325315 26.020377688063753 -10.78995753765465 2.9134835029071247 0.982471678064507 1.071736228635098 0.2810309740908007 0.054089164386697204 26815168.72004906 16646587.353373654 3276946.091679789 0.019794605528401187 1.6219686746147802e-11 10.78995753765465 0.08926455057059102 NFGEEVDDESLKELFSQFGK(ub)TLSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFGEEVDDESLKELFSQFGKTLSVK 25 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 189216000.0 44865000.0 91765000.0 52586000.0 True False 58078626.921365455 86658197.0820821 43015887.57792479 1.0 1.49208412243305 0.7406491829802623 25.791504010156203 -6.7300310229731855 1.723246256923844 1.2961210551762472 0.7411017341559009 0.559396399676289 0.20685899340035888 0.3361574654313426 1.9556967162929917 0.09512966657746058 0.23603787948096092 1.861954126876852e-07 6.7300310229731855 -0.5550193210203463 NFGIGQDIQPK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFGIGQDIQPKR 12 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 45108300.0 9855100.0 14035000.0 21218200.0 True False 12920131.536924157 11941032.708001511 19022744.203346338 1.0 0.9242191284102255 1.4723336329031682 23.62311742206862 -6.8719406738107915 1.1237115743389963 0.9565895821786259 1.5056499021585996 0.966585285005227 0.0443288841529647 0.13501113813390453 0.3174377564125063 0.03057649577174771 0.07264887654793535 1.3429484001929584e-07 6.8719406738107915 0.5490603199799737 NFGIGQDIQPK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFGIGQDIQPKR 12 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 61647400.0 17788800.0 13942300.0 29916300.0 True False 17224104.28109681 19509533.09813402 22080323.56023768 1.0 1.1326878181726658 1.281943211669387 24.03792562346505 -6.969599607481162 0.26758839280306435 0.9617945352573163 1.4573090825529438 0.9999790822771408 0.0005267043703475474 0.07643295704384544 0.009494655442511017 0.0029695542026433154 0.013928190974254314 1.0725076349562734e-07 6.969599607481162 0.4955145472956275 NFGIGQDIQPK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFGIGQDIQPKR 12 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 70585700.0 19178700.0 10424000.0 40983000.0 True False 29095490.05078062 8563755.756916275 32882692.086512998 1.0 0.29433275541913456 1.1301645728984986 24.79429220959196 -6.6829240724466406 1.89166346287135 0.5546835139807941 1.1270447675179525 0.337448650944576 0.2988908940827378 0.43207991305622695 2.991837314176388 0.12667274972899972 0.3328243640577538 2.0752763055762975e-07 6.6829240724466406 0.5723612535371584 NFGIGQDIQPK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFGIGQDIQPKR 12 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 42726810.0 9855100.0 10087710.0 22784000.0 True False 13498796.794063503 9642001.61660398 17402888.451209344 1.0 0.7142860036862201 1.2892177515304757 23.686327483591512 -6.77155620215998 1.568285093117983 0.8364523481536914 1.2926614458518073 0.7365795679371241 0.12046699652406492 0.26390567368721574 1.2811619397799783 0.06053686287668946 0.1439105878624469 1.692169246211468e-07 6.77155620215998 0.4562090976981159 NFGIGQDIQPK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFGIGQDIQPKR 12 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 52461100.0 17788800.0 22196100.0 12476200.0 True False 14792175.377458923 22076525.203719117 15084915.736568866 1.0 1.4924461507778268 1.0197902168977822 23.818330898899326 -10.425971914578865 4.391781012665164 0.9992283244052302 1.2561181838384918 0.28134992764631483 0.19296097698645343 0.0014622664657550656 0.00019112515840151892 0.18738507324525233 0.062277887527712406 3.749972521856796e-11 10.425971914578865 0.2568898594332616 NFGIGQDIQPK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFGIGQDIQPKR 12 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 73258500.0 19178700.0 19663000.0 34416800.0 True False 24827205.21869592 18568736.764833834 28153295.546189483 1.0 0.7479189301118275 1.1339695828908232 24.565418531684408 -6.7305175755553455 1.7214142519811542 0.8483853860847752 1.1337585090812563 0.561630178897635 0.10596458511028227 0.3352699487200689 1.946597880261765 0.04877730268203475 0.12096340721982242 1.8598692942552713e-07 6.7305175755553455 0.2853731229964811 NFGIWLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFGIWLR 7 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 91011000.0 31377000.0 37216000.0 22418000.0 False True 41135550.85530028 31663517.866831787 20098400.408640634 1.0 0.7697360849308275 0.48858955309336705 25.29388242729892 -6.968451687638826 0.2928192229829879 1.0531143172145638 0.19649076892595724 0.9999676585298944 0.0011892799006202894 0.07680840539362017 0.010819213127456467 0.004838686438361543 0.02541360514343885 1.0753462188256047e-07 6.968451687638826 -0.8566235482886067 down NFGIWLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFGIWLR 7 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 77198000.0 42032000.0 17603000.0 17563000.0 False True 40697717.1671536 24631969.698432304 12962723.421293894 1.0 0.6052420482766617 0.31851229807444525 25.278444536737624 -7.987432357386509 0.22085716162544008 1.215525378002782 2.7026032072972885e-14 0.9997681658097498 0.004253848240011154 0.10397976420667579 0.03880394729531804 0.07240216524308173 0.09925104915404054 1.0293608406182355e-08 7.987432357386509 -1.2155253780027548 down NFGIWLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFGIWLR 7 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 231201000.0 69427000.0 93828000.0 67946000.0 False True 105325834.79357539 77083660.31848991 54516443.31821027 1.0 0.7318590018257497 0.5175980178562576 26.650284109585144 -7.02481006425595 0.14939758794777125 1.254747406183981 2.9553063922631687e-09 0.9999986634038648 0.00022808438739561603 0.07201863332948807 0.00455537917698474 0.011172777217140415 0.026287831308150565 9.44473845200702e-08 7.02481006425595 -1.2547474032286745 NFGIWLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFGIWLR 7 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 113724000.0 31377000.0 35423000.0 46924000.0 False True 42977924.83154214 33857894.73180366 35841517.630115315 1.0 0.7877973369936849 0.8339517966630787 25.357092488821813 -10.681793943670904 6.695664208916195 1.001400067690001 0.810874566828382 0.9572426467630802 0.01884247925731333 0.00039653754642243917 1.8845115474369863e-05 0.018370687190962864 0.006081384030402778 2.0806836587569763e-11 10.681793943670904 -0.190525500861619 NFGIWLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFGIWLR 7 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 74090000.0 42032000.0 19062000.0 12996000.0 False True 34951470.333319515 18959309.222489245 15713403.513285236 1.0 0.5424466851231488 0.44957775348024553 25.0588498121719 -13.999999999999998 0.22417365658856528 3.812681052551674 0.4018459130331887 0.9995024146275026 0.005366707821779011 13.116601299828314 0.14995961443987574 16.368399559967568 0.050017537805382484 1.0000000000000041e-14 13.999999999999998 -3.4108351395184853 NFGIWLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFGIWLR 7 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 279109000.0 69427000.0 117200000.0 92482000.0 False True 89874620.11076872 110677716.97292015 75651224.94545399 1.0 1.2314679810219171 0.8417418048856877 26.421410431677593 -6.7457798237709525 1.6652429465393397 1.1367893045917605 0.841198873195155 0.6307317457101929 0.09725103149433516 0.3074512207184514 1.6760168470482968 0.04615878219288024 0.11257174866756776 1.7956437417037373e-07 6.7457798237709525 -0.29559043139660557 NFGSYVTHETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFGSYVTHETK 11 0 P63167;Q96FJ2 P63167 DYNLL1;DYNLL2 Dynein light chain 1, cytoplasmic;Dynein light chain 2, cytoplasmic 0 6150100.0 1294500.0 2824700.0 2030900.0 False True 1697102.0359558305 2403265.7705943612 1820761.9497684124 1.0 1.4160997510328304 1.0728653382016216 20.69464187689307 -10.20419485917594 6.02848935686296 0.9999961028687263 1.2444825446172274 0.40351092410640665 0.14012486226671397 7.33962595560072e-06 9.688885893145708e-07 0.13567747735970004 0.04522510482904854 6.248922533142942e-11 10.20419485917594 0.2444864417485011 NFGSYVTHETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFGSYVTHETK 11 0 P63167;Q96FJ2 P63167 DYNLL1;DYNLL2 Dynein light chain 1, cytoplasmic;Dynein light chain 2, cytoplasmic 0 4339720.0 858440.0 546280.0 2935000.0 False True 831189.2920862985 764412.4528125667 2166235.45188735 1.0 0.9196610929549863 2.606187871417429 19.66481754307559 -6.895717813424203 0.98796200333542 0.9214066399103931 2.768585013056761 0.984312146274473 0.09729422713616788 0.114625662577982 0.19573719446812185 0.0744157898636404 0.18977139807660706 1.2713999399315422e-07 6.895717813424203 1.8471783731463678 up NFGTK(ub)ISAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFGTKISAR 9 1 Q01813;Q01813-2;B1APP6;H0Y757 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 1 3185070.0 1072600.0 1230300.0 882170.0 True False 1406188.9870731765 1046744.0356718384 790891.5107721697 1.0 0.7443836108050582 0.5624361433937276 20.423359070129198 -7.524786820003992 0.11374521942772811 1.4023776417268332 1.978803698277677e-11 0.9999950428355153 0.0003995574546658586 0.13392562692702742 0.010305973621367745 0.04892029513701369 0.07248831740631942 2.986848398719441e-08 7.524786820003992 -1.4023776417070453 NFGTK(ub)ISAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFGTKISAR 9 1 Q01813;Q01813-2;B1APP6;H0Y757 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 1 5456300.0 1133300.0 1963800.0 2359200.0 True False 1097324.011837057 2747955.581081714 1741254.7455170816 1.0 2.5042335275989216 1.5868191406857162 20.0655581490768 -10.352671807043913 5.570586772800935 0.9997409777291266 2.045526334142328 0.6339302298734768 0.3745328551043027 0.0012051260988568849 0.00014004135485323348 0.36272565891022324 0.12087995920220168 4.43944002225056e-11 10.352671807043913 1.0457853564132016 NFGTK(ub)ISAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFGTKISAR 9 1 Q01813;Q01813-2;B1APP6;H0Y757 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 1 7534400.0 2108500.0 1355600.0 4070300.0 True False 3198748.65199784 1113682.5886488562 3265803.4209241336 1.0 0.3481619563804378 1.020962812718784 21.609076203615018 -10.942846735439355 12.746607865084329 1.0589390633000424 0.6845623845496109 0.22665524430837158 0.27466979942275294 0.136948112107271 0.0006140472893146156 0.07916656452476008 0.08864929657253784 1.1406522580746534e-11 10.942846735439355 -0.37437667875043146 NFGTK(ub)ISAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFGTKISAR 9 1 Q01813;Q01813-2;B1APP6;H0Y757 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 1 3401600.0 1072600.0 1055500.0 1273500.0 True False 1469169.2059251072 1008864.5199282598 972725.5285557886 1.0 0.6866904886513718 0.6620922386834825 20.48656913165209 -13.999999999999998 0.3607626631232698 5.118944136264286 0.6591626480538437 0.9997746667015925 0.0023090241105848323 21.778805662025604 0.19417122918583615 69.09025266206577 0.007080296591602584 1.0000000000000041e-14 13.999999999999998 -4.459781488210442 NFGTK(ub)ISAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFGTKISAR 9 1 Q01813;Q01813-2;B1APP6;H0Y757 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 1 5203500.0 1133300.0 2806000.0 1264200.0 True False 942389.1637026793 2790883.521052608 1528538.374999631 1.0 2.9614978912609 1.621982121477237 19.845963424511076 -10.05810087170468 4.854185745563094 0.9999654075213431 2.29174000541696 0.5535552736260124 0.5468550231174807 35806923.11429442 74193631.90307069 8278.94526494567 0.1872030331489867 8.747805701225312e-11 10.05810087170468 1.291774597895617 NFHK(ub)STGMTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFHKSTGMTSR 11 1 P42574;A8MVM1;C9JXR7 P42574 CASP3 Caspase-3;Caspase-3 subunit p17;Caspase-3 subunit p12 1 3540930.0 911830.0 1421100.0 1208000.0 True False 1195417.9601742812 1209077.4194044129 1083007.747954227 1.0 1.011426513307647 0.9059657659789002 20.189083692672742 -6.880068366909073 1.079464475819625 1.0070875402908313 0.8984834102841969 0.9737385166415943 0.007657410863393604 0.12756736215327474 0.27194583214490264 0.005464291265518 0.013215835113344631 1.3180492340889782e-07 6.880068366909073 -0.10860413000663438 NFHK(ub)STGMTSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFHKSTGMTSR 11 1 P42574;A8MVM1;C9JXR7 P42574 CASP3 Caspase-3;Caspase-3 subunit p17;Caspase-3 subunit p12 1 5497100.0 1565400.0 1488200.0 2443500.0 True False 1515707.2338566363 2082446.0208604748 1803474.0465712943 1.0 1.373910458658828 1.1898564619121403 20.531559686255235 -10.227063847234005 4.097438582905163 0.9998108641324529 1.2818834603103442 0.7577184062904085 0.07513972962776076 26480878.460880026 16.369518158150477 47936.669684512315 0.025722328035980187 5.928381628477252e-11 10.227063847234005 0.28207259617789127 NFHK(ub)STGMTSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFHKSTGMTSR 11 1 P42574;A8MVM1;C9JXR7 P42574 CASP3 Caspase-3;Caspase-3 subunit p17;Caspase-3 subunit p12 1 8213560.0 891060.0 1425200.0 5897300.0 True False 1351803.1652118536 1170861.9248615755 4731696.070121593 1.0 0.8661482344421637 3.500284798771014 20.366453666768074 -6.894933099509123 0.9927611142989118 0.8747437562803843 3.7499964836779354 0.9838718899562579 0.15384708574939684 0.1152311074376688 0.1992057039836301 0.11724732882622568 0.2979922978125924 1.27369927172887e-07 6.894933099509123 2.8752527273975512 up NFHK(ub)STGMTSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFHKSTGMTSR 11 1 P42574;A8MVM1;C9JXR7 P42574 CASP3 Caspase-3;Caspase-3 subunit p17;Caspase-3 subunit p12 1 4316000.0 1565400.0 1581800.0 1168800.0 True False 1301699.4589783566 1573278.529437282 1413190.6760793915 1.0 1.208634234719645 1.0856505058306924 20.31196496168951 -10.320591807665407 3.9319978020180124 0.9996935528401014 1.1471423702883405 0.6561940538312026 0.050207897285712524 35712349.30233834 49.72093402073213 101375.43361146009 0.017187498659529198 4.779783132611917e-11 10.320591807665407 0.14744881744823912 NFHK(ub)STGMTSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFHKSTGMTSR 11 1 P42574;A8MVM1;C9JXR7 P42574 CASP3 Caspase-3;Caspase-3 subunit p17;Caspase-3 subunit p12 1 5299140.0 891060.0 898480.0 3509600.0 True False 1153494.7354185206 848478.7981726045 2870888.8115370027 1.0 0.7355723195951582 2.488861650933641 20.137579988860523 -6.8684851080079605 1.1421595104533635 0.8517520988567561 2.5885945770119747 0.9631435230471841 0.14816463759038212 0.13831139203651985 0.3381820770398905 0.10076993703030884 0.23795565399839808 1.3536765075498466e-07 6.8684851080079605 1.7368424781552187 up NFILDQCNVYNSGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFILDQCNVYNSGQR 15 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 19120300.0 3644800.0 7623700.0 7851800.0 False True 4778368.096293408 6486273.676949841 7039371.055783935 1.0 1.3574244483134856 1.4731747144478868 22.18808656381371 -12.34156556046778 0.181266773738029 2.811060950081039e-08 1.5719719275222672 0.9994632388488712 0.004665970160511079 6.2099010203860345 0.12096323007663543 2.3672253539169033 0.08490769544285982 4.554434278939218e-13 12.34156556046778 1.5719718994116578 NFILDQCNVYNSGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFILDQCNVYNSGQR 15 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 19461500.0 3644800.0 7833300.0 7983400.0 False True 4992381.057016433 7487198.904740909 6097885.343284081 1.0 1.4997250448697599 1.2214382823831007 22.2512966253366 -10.14737662012898 4.496375460977123 0.9999594490898492 1.360581663635786 0.691216942851935 0.11361009529937008 79453400.91863401 4.497921985912576 43497.55191476698 0.03889175743190055 7.12235112021831e-11 10.14737662012898 0.3606222145459367 NFILDQTNVSAAAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFILDQTNVSAAAQR 15 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 102887000.0 21097000.0 39190000.0 42600000.0 False True 27658371.303638615 33343004.76142354 38192160.64805474 1.0 1.205530303841032 1.3808535661328094 24.721212868373655 -6.972971537404733 0.17305925599949817 0.8513341696655329 1.739758639239794 0.9999972485357483 0.00025811341763127714 0.07534969382439648 0.005415970301400316 0.007184908692065584 0.020108961756271394 1.0642127618333805e-07 6.972971537404733 0.888424469574261 NFILDQTNVSAAAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFILDQTNVSAAAQR 15 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 81472000.0 25685000.0 11374000.0 44413000.0 False True 24869643.73425817 15915697.514626414 32779902.938559804 1.0 0.6399648376427037 1.3180688589199683 24.567882504838312 -6.762490459991605 1.603409736580857 0.7915171817800398 1.3208285093215557 0.7009349363204449 0.15148882247549866 0.27875253060578054 1.4130355978409581 0.07453021920153605 0.178647693418318 1.7278639355270733e-07 6.762490459991605 0.5293113275415159 NFILDQTNVSAAAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFILDQTNVSAAAQR 15 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 178223000.0 14284000.0 140310000.0 23629000.0 False True 21669872.30027844 115270584.25296631 18958717.79304139 1.0 5.319393795019511 0.874888302539641 24.36918731592195 -6.6527336465191045 1.999066077067868 3.7968980341710323 0.8937327295637072 0.2050115921039305 1.8423589391366277 0.5019333015092339 3.84794813884663 0.746683242758541 2.0406064585855748 2.2246738682856943e-07 6.6527336465191045 -2.903165304607325 NFILDQTNVSAAAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFILDQTNVSAAAQR 15 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 83548000.0 21097000.0 29639000.0 32812000.0 False True 28897131.02498784 28329450.976933822 25062481.384352192 1.0 0.9803551415687899 0.8672999877628073 24.784422929896547 -6.93672698173429 0.6893706254647544 1.0013691669676963 0.8395429831162281 0.9977025396756651 0.0028029330942820063 0.0892927239872513 0.061657362112430114 0.0026649507629271695 0.009878930040974902 1.1568392580912138e-07 6.93672698173429 -0.16182618385146819 NFILDQTNVSAAAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFILDQTNVSAAAQR 15 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 47749000.0 25685000.0 11530000.0 10534000.0 False True 21358215.53843051 11467885.601474194 12736610.696287047 1.0 0.5369308864235248 0.5963330912814164 24.34828778027259 -10.254355205554702 5.5211173035850845 1.0000331180283806 0.5666319888528231 0.9861044533477502 0.024250848583081703 9.886728659934318e-06 1.335223871056515e-06 0.023482573260923352 0.007826927724463575 5.567302180267883e-11 10.254355205554702 -0.4334011291755575 NFILDQTNVSAAAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFILDQTNVSAAAQR 15 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 61123000.0 14284000.0 31842000.0 14997000.0 False True 18490919.579734407 30069964.708632443 12267699.882214628 1.0 1.6262016920774662 0.663444553382825 24.140313638014398 -6.731170701249837 1.719117501062649 1.3763508584027475 0.6639084801085579 0.564656145315712 0.26321574533373554 0.3340278938858116 1.9345245352669898 0.12131254570355002 0.30061276996902037 1.8570743808234943e-07 6.731170701249837 -0.7124423782941897 NFINNPLAQADWAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFINNPLAQADWAAK 15 0 P35579;Q5BKV1;B1AH99 P35579 MYH9 Myosin-9 0 22891100.0 4415600.0 9350900.0 9124600.0 False True 5788894.360731222 7955782.169522722 8180473.921343668 1.0 1.3743180776437232 1.4131323550893673 22.46485639895371 -12.058190810144637 0.3577525961689258 3.656072133035378e-19 1.4183908761562136 0.9996399520689359 0.0035346267764870386 5.619951722463084 0.1872812763970843 4.200719167251526 0.011277422324327801 8.745994297741296e-13 12.058190810144637 1.4183908761562136 NFINNPLAQADWAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFINNPLAQADWAAK 15 0 P35579;Q5BKV1;B1AH99 P35579 MYH9 Myosin-9 0 18242400.0 7284700.0 2865900.0 8091800.0 False True 7053451.18594317 4010268.8154710596 5972314.831203435 1.0 0.5685541318359342 0.84672235956005 22.749897896418027 -10.421576610775148 6.743464534980779 1.0000367572445519 0.7076382456979924 0.5956117933553562 0.11356170342973285 6.276441679623346e-05 5.383646830830049e-06 0.10996943388370485 0.03665188217919176 3.78811704397922e-11 10.421576610775148 -0.2923985115465595 NFINNPLAQADWAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFINNPLAQADWAAK 15 0 P35579;Q5BKV1;B1AH99 P35579 MYH9 Myosin-9 0 23102200.0 4415600.0 8980000.0 9706600.0 False True 6048166.647103201 8583233.907111097 7414100.9937021 1.0 1.4191463972346197 1.225842710080272 22.5280664604766 -10.258367989234245 4.8402063036100165 0.9999170437563628 1.3224945536578154 0.7877355680137419 0.07891589982266763 7.066620448429093e-05 1.0827891872897478e-05 0.07642958210005804 0.02546999714679396 5.516098475519293e-11 10.258367989234245 0.3225775099014526 NFINNPLAQADWAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFINNPLAQADWAAK 15 0 P35579;Q5BKV1;B1AH99 P35579 MYH9 Myosin-9 0 13345400.0 7284700.0 2352700.0 3708000.0 False True 6057550.816928347 2340025.5381256146 4483325.656145092 1.0 0.38629895296729694 0.7401218399383548 22.530303171852303 -10.297345396636999 5.898799065079926 1.000031293488192 0.5632103964528934 0.6701784741987438 0.14444758873292798 5.945119034997722e-05 7.081818830029219e-06 0.13987077045974858 0.04662025879686996 5.0426009739524655e-11 10.297345396636999 -0.4368208970352987 NFIQLCLEAYYDNTIFHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFIQLCLEAYYDNTIFHR 18 0 D6REK3;Q6UX04-2;Q6UX04 D6REK3 CWC27 Peptidyl-prolyl cis-trans isomerase CWC27 homolog 0 28905800.0 5954800.0 11897000.0 11054000.0 False True 9033866.954193363 9773887.398314739 8869172.054859687 1.0 1.081916243384332 0.9817691692639742 23.106912236039733 -6.689294173635947 1.8690979059336925 1.0513905785238953 0.982119784324422 0.3670664084893849 0.03464981454664927 0.4181754789915991 2.831934264488194 0.014834014664758068 0.038660734963988884 2.0450589267008583e-07 6.689294173635947 -0.06927079419947324 NFIQYFHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFIQYFHK 8 0 B0QY89;Q9Y262;Q9Y262-2;C9JHP4;C9K0Q7;H7C3A0 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 18254400.0 4623400.0 5570300.0 8060700.0 False True 6061322.173069296 4739232.952859336 7226656.08769424 1.0 0.7818810512854675 1.1922573790587423 22.53120109643359 -6.762332380172383 1.603880547368754 0.8736693988949092 1.1939213002124307 0.7003235996266859 0.09177411754935086 0.2790277379509906 1.4152077667418559 0.04513763986449708 0.10821628817656435 1.7284929790596996e-07 6.762332380172383 0.32025190131752146 NFIQYFHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFIQYFHK 8 0 B0QY89;Q9Y262;Q9Y262-2;C9JHP4;C9K0Q7;H7C3A0 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 12437600.0 3193500.0 2861300.0 6382800.0 False True 3092124.0905335187 4003832.011482376 4710953.200104456 1.0 1.294848425954196 1.5235330349538536 21.56016678677744 -6.973965002999466 0.13282056701561448 0.6601531217191324 2.1641597835407933 0.9999991439832983 0.00019818847336022666 0.07503587815849252 0.003996993267549255 0.013952083416230388 0.03080725562699616 1.0617811158660774e-07 6.973965002999466 1.504006661821661 NFIQYFHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFIQYFHK 8 0 B0QY89;Q9Y262;Q9Y262-2;C9JHP4;C9K0Q7;H7C3A0 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 16519600.0 4623400.0 4549200.0 7347000.0 False True 6332795.922687063 4348201.301807327 5611789.916214664 1.0 0.6866163626448183 0.8861472854526362 22.594411157956483 -10.709284627638754 5.751168883872117 1.0045465816893149 0.7863818240487306 0.6044696667370347 0.08145815813096874 0.004832355136671548 0.0002442700586003714 0.08026045056642672 0.026290507487831023 1.9530590416617804e-11 10.709284627638754 -0.2181647576405843 NFLEGDWK(ub)TISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFLEGDWKTISK 12 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 1 4198480.0 1511900.0 912480.0 1774100.0 True False 1463905.5620722177 1276838.0225203375 1309409.9881408345 1.0 0.8722133828857932 0.8944634285611373 20.48139105633094 -10.68281491046109 9.756168878082912 1.0000938461818487 0.8833384057267272 0.9734430624322903 0.009083543109702078 1.8556698528688207e-05 6.032944466946062e-07 0.008802139053495969 0.0029317009323694423 2.0757980017180262e-11 10.68281491046109 -0.11675544045512154 NFLEGDWK(ub)TISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFLEGDWKTISK 12 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 1 4269500.0 1511900.0 1423400.0 1334200.0 True False 1257211.838526497 1415731.8616772213 1613175.0513561973 1.0 1.1260885542857408 1.2831370194914038 20.261796331765215 -6.968162163721572 0.2988434409611017 0.9723854522616998 1.4417530169838286 0.9999642854703411 0.0006921370766551849 0.07690370674373305 0.011153392296379768 0.00262054688195258 0.014102333834198065 1.0760633411081757e-07 6.968162163721572 0.4693675647221288 NFLHSK(ub)ENPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFLHSKENPK 10 1 Q8N999;Q8N999-3 Q8N999 C12orf29 Uncharacterized protein C12orf29 1 2216070.0 564400.0 777670.0 874000.0 True False 546483.4309369408 1088197.6864954766 645073.1805620259 1.0 1.9912729735095018 1.1804075733020007 19.059818229313894 -10.156173723407937 4.395549173752781 0.9999079570353574 1.5858402729093528 0.4103720118523899 0.33103441376384085 233541875.53791618 133710899.69762793 291094.02058824606 0.12114618994088856 6.979531579425563e-11 10.156173723407937 0.5859323158739954 NFLIEPFVPHSQAEEFYVCIYATR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFLIEPFVPHSQAEEFYVCIYATR 24 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 36566500.0 5952500.0 15134000.0 15480000.0 False True 9030377.686040856 12433219.457518306 12420371.214874964 1.0 1.3768216446514254 1.3753988644433284 23.10635489749358 -10.105824410759224 4.525261985558581 0.9999661984689648 1.3761102545607136 0.9999892664135875 0.0005808476330421283 1.9809937360681412e-07 3.9143836745301104e-08 0.0005624537580894209 0.0001874677610747271 7.837464545941484e-11 10.105824410759224 0.3761440560917487 NFLINYYNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFLINYYNR 9 0 Q9Y5X3;A0A087WUY5;Q5QPE5;Q5QPE4 Q9Y5X3 SNX5 Sorting nexin-5 0 39517000.0 11035000.0 14798000.0 13684000.0 False True 14466991.863092005 12590196.082152206 12268110.946196726 1.0 0.8702704889377968 0.848007039908204 23.786261636159935 -13.999999999999995 0.24795852219945771 1.893008168327716 0.8388797995367651 0.999538887032299 0.0014391833045305025 13.917844309600577 0.15757232223888698 6.183064688034379 0.010392300761917422 1.0000000000000123e-14 13.999999999999995 -1.054128368790951 NFLINYYNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFLINYYNR 9 0 Q9Y5X3;A0A087WUY5;Q5QPE5;Q5QPE4 Q9Y5X3 SNX5 Sorting nexin-5 0 33928400.0 12575000.0 5440400.0 15913000.0 False True 12175813.508206991 7612780.091311197 11744907.920232859 1.0 0.6252379018600995 0.964609708609311 23.537514831184243 -10.35059841745963 8.221465451782523 1.0000009394692904 0.7949238065911443 0.32744862976680966 0.13854795993699806 2.385898745884041e-06 1.884353323990302e-07 0.13414910101366326 0.04471616179058382 4.460685274963881e-11 10.35059841745963 -0.2050771328781461 NFLINYYNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFLINYYNR 9 0 Q9Y5X3;A0A087WUY5;Q5QPE5;Q5QPE4 Q9Y5X3 SNX5 Sorting nexin-5 0 24360000.0 7227000.0 9682900.0 7450100.0 False True 10963887.364471598 7954910.842156997 5977584.469505175 1.0 0.7255556882073444 0.5452066653726758 23.38625607629551 -8.471524110001663 0.10534254140437277 1.54138637698899 3.421404279001593e-14 0.9999754244120056 0.0009269547331354502 0.13831838205699298 0.025110553174835355 0.1819191953949679 0.16598235075917295 3.376571029760603e-09 8.471524110001663 -1.5413863769889558 NFLINYYNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFLINYYNR 9 0 Q9Y5X3;A0A087WUY5;Q5QPE5;Q5QPE4 Q9Y5X3 SNX5 Sorting nexin-5 0 34669400.0 11035000.0 9514400.0 14120000.0 False True 15114937.70966207 9094022.348086623 10785146.810528269 1.0 0.601657944132536 0.7135422598290944 23.849471697682826 -10.305460589801633 8.298601980683753 1.000000589966703 0.6576001019808169 0.92585602050713 0.04567658061283909 4.986099780385074e-07 4.169223767597359e-08 0.044226235447190135 0.014742053002102197 4.949250210195305e-11 10.305460589801633 -0.3424004879858862 NFLINYYNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFLINYYNR 9 0 Q9Y5X3;A0A087WUY5;Q5QPE5;Q5QPE4 Q9Y5X3 SNX5 Sorting nexin-5 0 28731000.0 12575000.0 9382900.0 6773100.0 False True 10456669.666955955 9332352.455340171 8189323.89472393 1.0 0.8924784613624421 0.7831675050999223 23.31792010661852 -6.970919716327442 0.23518901779865525 1.0416685285818474 0.6308344358191537 0.9999886888747966 0.00029766303091638825 0.07600539904796737 0.00795462400129442 0.0027043741564338674 0.010750315318668626 1.0692525229620671e-07 6.970919716327442 -0.4108340927626938 NFLINYYNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFLINYYNR 9 0 Q9Y5X3;A0A087WUY5;Q5QPE5;Q5QPE4 Q9Y5X3 SNX5 Sorting nexin-5 0 30348800.0 7227000.0 14248000.0 8873800.0 False True 9355493.965467697 13455086.2750014 7258859.452876981 1.0 1.4382015877158183 0.7758926978810893 23.15738239838796 -6.728286330498636 1.7294092133004977 1.2642066672831445 0.7764027093813389 0.5513508271640594 0.1842354247422975 0.33945154772178365 1.9881588558540821 0.08444792582862472 0.20996513136098843 1.86944920548054e-07 6.728286330498636 -0.48780395790180553 NFLSTPQFLYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFLSTPQFLYR 11 0 E5RGY0;B4E1G1;Q9BUN8-2;Q9BUN8 E5RGY0 DERL1 Derlin-1 0 3034200.0 0.0 0.0 3034200.0 False True 0.0 0.0 2720250.0901015867 0.0 NFLSTPQFLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFLSTPQFLYR 11 0 E5RGY0;B4E1G1;Q9BUN8-2;Q9BUN8 E5RGY0 DERL1 Derlin-1 0 4927900.0 0.0 2059600.0 2868300.0 False True 0.0 1968600.0618135885 2190866.614492791 0.0 NFLYAWCGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFLYAWCGK 9 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 67605000.0 16513000.0 17171000.0 33921000.0 False True 21648702.912119467 14609153.732033772 30411180.313208096 1.0 0.6748281313359986 1.4047576169648106 24.367777252290026 -6.785589811035621 1.5137698977871523 0.8172132630368204 1.4116191001339302 0.786754972456408 0.1378807128804482 0.24199400962768824 1.0954916015989689 0.07171135042129444 0.16845878314853682 1.6383632167475374e-07 6.785589811035621 0.5944058370971098 NFLYAWCGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFLYAWCGK 9 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 25468700.0 13329000.0 3139300.0 9000400.0 False True 12905878.190925734 4392838.8612332335 6642925.233787706 1.0 0.3403750443206482 0.5147208996950258 23.621524978335152 -10.714194516986348 10.338928474887677 1.0006350627675085 0.427547972009102 0.9349573643067448 0.07117639740604956 0.0010428276935903111 2.8827418899553056e-05 0.06897693095734952 0.022972083483055895 1.931103197785785e-11 10.714194516986348 -0.5730870907584065 NFLYAWCGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFLYAWCGK 9 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 40133400.0 9326400.0 16713000.0 14094000.0 False True 14148830.651170319 13730434.570734978 11308314.722380353 1.0 0.9704289286690463 0.7992402341351783 23.75417948875502 -6.936596834512057 0.6904951477174917 1.0020807555441285 0.7573580202575856 0.9976833424793736 0.0042594750588376504 0.08935402329525793 0.061939718195819116 0.004046264734810628 0.014968068494031197 1.1571859859083713e-07 6.936596834512057 -0.24472273528654287 NFLYAWCGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFLYAWCGK 9 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 65483000.0 16513000.0 20672000.0 28298000.0 False True 22618302.347045746 19758642.686837517 21614595.215603996 1.0 0.8735687755725071 0.9556241173169724 24.430987313812917 -10.667533882693297 5.0105755901171545 1.0018434413705166 0.9145964464447393 0.5908957581664176 0.033498952990607546 0.0007044301031269992 4.674096204721148e-05 0.033121111592862684 0.0108117405873338 2.1501369238772232e-11 10.667533882693297 -0.08724699492577737 NFLYAWCGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFLYAWCGK 9 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 13329000.0 13329000.0 0.0 0.0 False True 11083654.074819565 0.0 0.0 1.0 0.0 0.0 23.40193025376943 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 NFLYAWCGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFLYAWCGK 9 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 43360400.0 9326400.0 15237000.0 18797000.0 False True 12073208.650828546 14389047.555600537 15376138.873507256 1.0 1.1918163573370417 1.2735751794078403 23.52530581084747 -13.999999999990926 0.11650751985470215 0.08288532448515937 1.4104263661060856 0.9997102348329311 0.0019517832289087673 11.978304039322746 0.10457933794104726 2.556125732778729 0.12143403236593706 1.0000000000208928e-14 13.999999999990926 1.3275410416209263 NFLYDIAGCSGTFTVQNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFLYDIAGCSGTFTVQNR 18 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 4459470.0 1817800.0 1687000.0 954670.0 False True 2383153.4036002434 1435306.1758744966 855889.906241276 1.0 0.602271836007775 0.35914175937993675 21.184440390130646 -8.768966520804359 0.16750920737052405 1.422448977239041 2.2398570638776953e-19 0.9998078865904919 0.0036613107805024987 0.302601195633351 0.04857141380015636 0.21520342074293938 0.15025349490598378 1.7022897306339365e-09 8.768966520804359 -1.422448977239041 down NFLYDIAGCSGTFTVQNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFLYDIAGCSGTFTVQNR 18 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 15489700.0 10245000.0 2407400.0 2837300.0 False True 9919778.082829464 3368687.37442515 2094126.0128245256 1.0 0.3395930177365705 0.2111061351714441 23.2418764155026 -13.999999999999993 0.23016498696540721 5.1721396806510755 0.14873270217167833 0.9995100196949398 0.007650188274865188 13.296437396075758 0.15190414987324694 25.354244588595336 0.06662786700916912 1.0000000000000164e-14 13.999999999999993 -5.0234069784793975 NFLYDIAGCSGTFTVQNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFLYDIAGCSGTFTVQNR 18 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 63049000.0 14184000.0 32778000.0 16087000.0 False True 21518164.989299174 26928509.8043171 12907397.398817433 1.0 1.2514315146160675 0.5998372726129848 24.35905171823457 -6.802092428626733 1.4474245929410725 1.1383582174606894 0.5903776269207287 0.8381997008121066 0.10792700543026484 0.2177794457220753 0.900542618959699 0.0586550703986214 0.136235636014111 1.577275550656908e-07 6.802092428626733 -0.5479805905399607 NFLYDIAGCSGTFTVQNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFLYDIAGCSGTFTVQNR 18 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 6023100.0 1817800.0 1234400.0 2970900.0 False True 2489889.7841978935 1179860.1263850734 2269234.6076061167 1.0 0.4738603828462873 0.9113795405755842 21.247650451653538 -10.074771741625778 7.365876296915805 1.0000000470499064 0.6926199617109373 0.39690228065055166 0.17861644818817474 1.3787352472408156e-07 1.7493347005998235e-08 0.1729446580685299 0.057648210765960065 8.418374819802348e-11 10.074771741625778 -0.3073800853389691 NFLYDIAGCSGTFTVQNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFLYDIAGCSGTFTVQNR 18 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 17739500.0 10245000.0 1829500.0 5665000.0 False True 8519171.430454368 1819644.1203726807 6849525.3079994405 1.0 0.21359402557246468 0.8040130855347892 23.022281690936875 -10.260695405503286 7.515056733721675 1.0000013656494895 0.5088035555592647 0.4799370872289378 0.24103757188690003 5.515315960800377e-06 5.423607631585635e-07 0.2333842756289548 0.0777945418106864 5.486616364530029e-11 10.260695405503286 -0.4911978100902248 NFLYDIAGCSGTFTVQNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFLYDIAGCSGTFTVQNR 18 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 37327000.0 14184000.0 13079000.0 10064000.0 False True 18361467.60843971 12351142.152634993 8232455.265360272 1.0 0.6726663911635192 0.44835497036066363 24.13017804032702 -8.088293357745403 0.1482840722846631 1.3697660412030055 1.373388034556383e-14 0.9999448689850007 0.0016818585087237205 0.0943925807227807 0.027022720243110938 0.1046537724351804 0.11982274368647615 8.160309715928229e-09 8.088293357745403 -1.3697660412029917 down NFNETFLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFNETFLKR 9 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 16627200.0 8741900.0 5695400.0 2189900.0 True False 8464393.16957413 7969602.921118641 1616299.4944082159 1.0 0.9415445102155642 0.19095279035691778 23.01297521126346 -6.9224409489118255 0.8064197994183998 1.015150084758608 0.06284756008120318 0.9948324286423618 0.026481601283502975 0.0967569241216325 0.09832872806337854 0.023116578148876275 0.07094657223333319 1.1955260704883824e-07 6.9224409489118255 -0.9523025246774047 down NFNETFLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFNETFLKR 9 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 8785100.0 6511000.0 2274100.0 0.0 True False 9877663.017860064 1868269.0873756025 0.0 1.0 0.189140800207249 0.0 23.23573832051118 -9.567759319948943 0.4465957689639533 1.2290257996391973 5.4121554628965765e-22 0.9979333063983463 0.019718754569841627 0.9881633326891567 0.2108356028317909 0.40168373932956325 0.04346852481277513 2.705457276083785e-10 9.567759319948943 -1.2290257996391973 NFNETFLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFNETFLKR 9 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 15773700.0 6140300.0 8307600.0 1325800.0 True False 8410534.845368197 7940542.762440555 1012673.3457081007 1.0 0.9441186450601922 0.12040534452642979 23.00376611703709 -6.937688451990361 0.836156943139014 1.016547952050667 7.63976771046823e-24 0.994369983392567 0.030172534494923714 0.09338854156206036 0.10530146801444536 0.026113460892156506 0.07460827506173505 1.1542810026057228e-07 6.937688451990361 -1.016547952050667 down NFNETFLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFNETFLKR 9 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 19057400.0 8741900.0 9102200.0 1213300.0 True False 7269277.181833977 9053164.64195475 1466995.4203346402 1.0 1.245400940904927 0.20180760530093445 22.793380486697735 -6.844718042435644 1.26019017380062 1.1305895779145867 0.16412658352413834 0.9322724763512362 0.11594528738374969 0.16336904451261064 0.5019021860320136 0.07207913015447837 0.16633886979669252 1.4298219423767466e-07 6.844718042435644 -0.9664629943904484 down NFNETFLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFNETFLKR 9 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 19684000.0 6511000.0 7139200.0 6033800.0 True False 8428617.850997685 6741897.244138834 4935710.3120161705 1.0 0.799881708166518 0.585589523605218 23.00686464260363 -6.970254612943497 0.2520294839547395 1.0663307810485443 0.31284784557759643 0.9999843002615592 0.0006704553568773753 0.07622016910415091 0.008733991877314952 0.004714533861213676 0.020470467523619595 1.0708912919016998e-07 6.970254612943497 -0.7534829354709478 NFPNAIEHTLQWAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFPNAIEHTLQWAR 14 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 36154500.0 9711800.0 11687200.0 14755500.0 False True 12732263.849204995 9943515.316348797 13228742.404750502 1.0 0.7809699385839912 1.0389937375965161 23.601985623407295 -6.681710992411395 1.8951863343091337 0.8616402544826639 1.0380415434887549 0.33233632903402166 0.09279389545395618 0.4346821848831678 3.01983339199972 0.03926172222181342 0.10334731221198747 2.081081112147318e-07 6.681710992411395 0.17640128900609098 NFPNAIEHTLQWAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFPNAIEHTLQWAR 14 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 27410600.0 9880100.0 6304500.0 11226000.0 False True 9566461.633593315 8821919.72753317 8285573.827218886 1.0 0.9221716519046463 0.8661064189212342 23.189553980178662 -6.974681814067452 0.09350961740558865 1.1545550163045557 0.6323062539487225 0.999999796675196 2.407351277162241e-05 0.07481048256356546 0.0027335785984913116 0.0055256210114512285 0.00965630106802413 1.0600300719756781e-07 6.974681814067452 -0.5222487623558332 NFPNAIEHTLQWAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFPNAIEHTLQWAR 14 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 44375400.0 3715900.0 28611900.0 12047600.0 False True 5637291.968678577 23505882.899204977 9666386.579349337 1.0 4.16971181017522 1.7147216488088357 22.426570859325288 -6.581655654230209 2.260069965845271 3.1562658751512194 1.7208889385698805 0.0 1.3764235916457015 0.694331796888328 6.672950110757729 0.5108136498613616 1.5382169574748041 2.6202597505965117e-07 6.581655654230209 -1.435376936581339 NFPNAIEHTLQWAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFPNAIEHTLQWAR 14 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 34681000.0 9711800.0 9684400.0 15284800.0 False True 13302514.911526624 9256511.185971795 11674845.040337276 1.0 0.6958467062458266 0.8776419434960397 23.665195684930186 -10.275504170241483 5.481347750073646 1.0000227869447613 0.7867443256160772 0.6472341702133944 0.07421759482190125 2.0669418713167076e-05 2.731944129285332e-06 0.07186855007470061 0.023953625728395194 5.302685007885204e-11 10.275504170241483 -0.2132784613286841 NFPNAIEHTLQWAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFPNAIEHTLQWAR 14 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 17992500.0 9880100.0 3797600.0 4314800.0 False True 8215740.912643465 3777141.575035423 5217004.730618893 1.0 0.4597444850314911 0.6350011260202082 22.969959255612938 -10.582480293907484 6.992798439309915 1.0005446399500975 0.5473728055258505 0.8989231891842414 0.07154822407608273 0.000608205077711336 3.631404381418212e-05 0.06935428311314497 0.023092090024782064 2.615289114071268e-11 10.582480293907484 -0.4531718344242469 NFPNAIEHTLQWAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFPNAIEHTLQWAR 14 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 21618700.0 3715900.0 17902800.0 0.0 False True 4810305.801339625 16906493.442174017 0.0 1.0 3.5146400541657283 0.0 22.197697181417738 -6.71468349067158 1.7785224692122847 2.5386063381382766 0.007170371039721591 0.4870886186463327 1.0589355455635916 0.36586103079336235 2.2586630667968186 0.4733073066131479 1.1956381387157944 1.9289301854315285e-07 6.71468349067158 -2.531435967098555 NFQAEK(ub)LLEEEEKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFQAEKLLEEEEKR 14 2 M0R2S3;Q9BW85 M0R2S3 CCDC94 Coiled-coil domain-containing protein 94 1 13732800.0 1924800.0 2787100.0 9020900.0 True False 2491691.543480317 2631995.4349421985 7379188.762250436 1.0 1.0563086919121254 2.9615177615217227 21.24869405171705 -6.913213410685613 0.8735539679132883 0.9468354654952708 3.2254493952804295 0.9920790288138537 0.08113991670040019 0.10233155166806948 0.12752036151864557 0.06750432885631098 0.19076759964522919 1.2211994198672671e-07 6.913213410685613 2.2786139297851586 up NFQLNQDK(ub)MNFSTLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFQLNQDKMNFSTLR 15 1 Q9Y244 Q9Y244 POMP Proteasome maturation protein 1 23784900.0 5015100.0 8331800.0 10438000.0 True False 6574844.666297487 7088727.917102036 9357975.888366085 1.0 1.0781589949095989 1.4232999201235685 22.648525379803715 -6.942609953471073 0.6348227964364915 0.9962317634375759 1.5239826036358728 0.9984861132468864 0.007155789302947716 0.08659595897454239 0.049337950082913806 0.007111965275992946 0.029381083384454693 1.1412743233743077e-07 6.942609953471073 0.5277508401982969 NFQLNQDK(ub)MNFSTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFQLNQDKMNFSTLR 15 1 Q9Y244 Q9Y244 POMP Proteasome maturation protein 1 41126000.0 13217000.0 13211000.0 14698000.0 True False 12797433.569620023 18486221.194454875 10848152.869451558 1.0 1.444525661640435 0.847681905159806 23.609351181654056 -6.707293458202379 1.8047771048798738 1.2740394458974251 0.8491903974577895 0.45223061419286015 0.18740252615042508 0.3805648962111231 2.4146169763700787 0.08268424760804899 0.21075510552561696 1.9620340579117056e-07 6.707293458202379 -0.42484904843963567 NFQLNQDK(ub)MNFSTLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFQLNQDKMNFSTLR 15 1 Q9Y244 Q9Y244 POMP Proteasome maturation protein 1 77022000.0 21505000.0 32718000.0 22799000.0 True False 32624657.226091284 26879217.273099214 18292767.65684332 1.0 0.8238927105601218 0.560703750236304 24.959459408167895 -6.965318417488764 0.35254486253551837 1.0247007705203466 0.35097993491355645 0.999919558495243 0.0016189931478052947 0.07785306174372703 0.014479886110575393 0.003589974909240692 0.022584149909032004 1.083132488106679e-07 6.965318417488764 -0.6737208356067901 NFQLNQDK(ub)MNFSTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFQLNQDKMNFSTLR 15 1 Q9Y244 Q9Y244 POMP Proteasome maturation protein 1 24958500.0 5015100.0 9746400.0 10197000.0 True False 6869317.997981542 9315771.820965208 7788678.613807123 1.0 1.356142170693295 1.1338357921551634 22.711735441326606 -10.134631567499959 3.967209696848954 0.9999111214910462 1.2449889813799098 0.6182189721326592 0.0907561993416856 63891893.839033864 74378991.96947789 65990.80058038501 0.03321336773255368 7.334464865456725e-11 10.134631567499959 0.24507785988886355 NFQLNQDK(ub)MNFSTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NFQLNQDKMNFSTLR 15 1 Q9Y244 Q9Y244 POMP Proteasome maturation protein 1 46929600.0 16150400.0 17978200.0 12801000.0 True False 13429773.184032243 17881347.868206687 15477629.91486337 1.0 1.3314705783316791 1.1524863229459446 23.678931603449332 -10.499320022722314 6.84188264379912 0.9999091796763997 1.2419784506388118 0.7090518804916521 0.07307001628117361 0.00010126552937761291 7.410405995072989e-06 0.07077614788059437 0.023583246347007533 3.167232733910923e-11 10.499320022722314 0.24206927096241215 NFQLNQDK(ub)MNFSTLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFQLNQDKMNFSTLR 15 1 Q9Y244 Q9Y244 POMP Proteasome maturation protein 1 76182000.0 21505000.0 28559000.0 26118000.0 True False 27838646.426924426 26969666.544621333 21364791.993310776 1.0 0.9687851245000673 0.7674508187527251 24.730585730260344 -6.934324138433007 0.7103982004761557 1.002625972350405 0.7211646634827816 0.9973219898923471 0.005333208225211085 0.09045386814941982 0.06713017780505509 0.004990477707685908 0.01780406787608453 1.1632575007428627e-07 6.934324138433007 -0.2814613088676233 NFQNIFPPSATLHLSNIPPSVSEEDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFQNIFPPSATLHLSNIPPSVSEEDLK 27 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 74722000.0 36297900.0 9974600.0 28449500.0 False True 35145643.03296594 13957509.796851832 20997722.483294453 1.0 0.3971334308426212 0.5974488064878765 25.066842515263613 -10.287685216795198 6.188296465821649 1.0000196472247962 0.4972911186652569 0.8935872460539495 0.08177840966080344 2.2168157134319345e-05 2.5516919065021103e-06 0.07918469273453721 0.026393868224634746 5.1560222546315875e-11 10.287685216795198 -0.5027285285595393 NFQNIFPPSATLHLSNIPPSVSEEDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFQNIFPPSATLHLSNIPPSVSEEDLK 27 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 141593000.0 16485000.0 78397000.0 46711000.0 False True 25008950.21493214 64406442.83144329 37478550.37584143 1.0 2.5753357209287424 1.4986055013802237 24.575941163893635 -10.503308465590932 5.456384398505029 0.9979787555951521 2.0369706111538046 0.5529090551786694 0.4395732714214724 0.010822509655375125 0.0009851663761394074 0.42616758565643026 0.14187166330443818 3.1382788821709555e-11 10.503308465590932 1.0389918555586526 NFQNIFPPSATLHLSNIPPSVSEEDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFQNIFPPSATLHLSNIPPSVSEEDLK 27 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 58231300.0 36297900.0 12077900.0 9855500.0 False True 30183312.11961835 12012833.955424555 11916239.483316597 1.0 0.3979958828844543 0.3947956220341822 24.84724779069789 NFQNIFPPSATLHLSNIPPSVSEEDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFQNIFPPSATLHLSNIPPSVSEEDLK 27 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 50903000.0 16485000.0 18650000.0 15768000.0 False True 21340157.467930708 17612111.105332416 12898385.79334269 1.0 0.8253037088315455 0.6044184918844185 24.347067485986084 -6.967941145691656 0.30336339488099495 1.0368094453568713 0.3859582425428237 0.9999615729851156 0.0010033583596263918 0.07697661750587777 0.011408909928614918 0.0036048022923174414 0.019740766439957085 1.0766111029083181e-07 6.967941145691656 -0.6508512028140476 NFQPVIIFSFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFQPVIIFSFSK 12 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 11584100.0 2660200.0 4920300.0 4003600.0 False True 3487547.961413443 4186210.4191791783 3589345.8772430015 1.0 1.200330566201756 1.0291889651284685 21.733781626615116 -10.755905364231774 2.904518408825545 0.977587277919018 1.1147597657029804 0.37481414277313285 0.06986826706854206 52202155.821444415 37061726.00240872 8289101.888123511 0.025569165454117786 1.7542627261641392e-11 10.755905364231774 0.1371724877839624 NFQPVIIFSFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFQPVIIFSFSK 12 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 24982900.0 7566500.0 8433500.0 8982900.0 False True 7326305.599192709 11801040.530121509 6630009.008776459 1.0 1.6107764507423599 0.9049593849193275 22.80465445017469 -6.677793755785849 1.9094103020268058 1.3871962958024704 0.9076674188581184 0.3142238512441403 0.25898523374332766 0.4434245250544507 3.1236162664117506 0.10890497741468551 0.28807726095599584 2.0999368960903615e-07 6.677793755785849 -0.479528876944352 NFQPVIIFSFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFQPVIIFSFSK 12 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 133007000.0 37817000.0 35751000.0 59439000.0 False True 57371153.793029256 29370954.7261621 47690855.59696079 1.0 0.5119463839287601 0.8312688946261937 25.77382219657728 -10.09195776481854 7.26376410421932 1.0000000832891351 0.6716076392774786 0.5850883137423424 0.13036286909885594 1.7584351882427216e-07 2.1880380284184315e-08 0.12622333816097084 0.042074435081973886 8.091745876610332e-11 10.09195776481854 -0.32839244401165657 NFQPVIIFSFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFQPVIIFSFSK 12 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 14237500.0 2660200.0 3732700.0 7844600.0 False True 3643747.829201906 3567776.9716117657 5991867.044608352 1.0 0.9791503525624659 1.6444241823180055 21.796991688138007 -6.89966773876717 0.963396615916693 0.9720867336638583 1.7137788545220918 0.9863990637487143 0.036015076683972656 0.1116500187737181 0.1788170224374463 0.028055955404873496 0.07287345156385892 1.2598889334985506e-07 6.89966773876717 0.7416921208582334 NFQPVIIFSFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFQPVIIFSFSK 12 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 17586400.0 7566500.0 3962200.0 6057700.0 False True 6291880.002785075 3940854.8421648736 7324337.062359799 1.0 0.6263397967571648 1.1640935712565577 22.585059725608968 -6.71982349642029 1.7598055854196786 0.7726267055211548 1.1632543441133203 0.5117184688264191 0.15724130535469208 0.35567674318011727 2.1525701733838507 0.07094661000917137 0.17814926057113362 1.906235282236542e-07 6.71982349642029 0.39062763859216554 NFQPVIIFSFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFQPVIIFSFSK 12 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 102316000.0 37817000.0 32089000.0 32410000.0 False True 48954851.98451527 30303218.941502012 26511712.554682624 1.0 0.619003381954604 0.5415543399675368 25.54494851866973 -13.999999999999996 0.22395658627908596 3.3397903405013802 0.5016652599798072 0.9995021627808013 0.004470680092766487 13.11026306587877 0.14988773051591328 13.595051120268353 0.041770759540981216 1.0000000000000082e-14 13.999999999999996 -2.838125080521573 NFSDNQLQEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFSDNQLQEGK 11 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 50548300.0 1794300.0 26671000.0 22083000.0 False True 2352344.6760259178 22691790.762743738 19798062.995093722 1.0 9.646456573311164 8.416310414399318 21.165668035094104 -10.46765598167107 6.599291430020024 0.9975356991923681 9.031383493855204 0.9827090474005162 0.5022050663964491 0.018188550082331344 0.001467208414268613 0.4857216320884844 0.16208598821120315 3.406779445692763e-11 10.46765598167107 8.033847794662837 NFSDNQLQEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFSDNQLQEGK 11 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 49367700.0 15653000.0 6054700.0 27660000.0 False True 15156104.083019001 8472373.284843383 20415016.21778678 1.0 0.5590073305405633 1.3469831103007468 23.85339561676777 -6.754857301083754 1.6320982876080798 0.7422118763191549 1.3491261569324227 0.6695194330760519 0.18536939868499636 0.2916439249873189 1.529889834037188 0.08967260518208216 0.2165827314146008 1.7585013210718205e-07 6.754857301083754 0.6069142806132678 NFSDNQLQEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFSDNQLQEGK 11 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 210437200.0 3703200.0 203930000.0 2804000.0 False True 5618025.140184203 167537098.18763766 2249788.170963141 1.0 29.821350742859877 0.4004589005611633 22.421631649740412 -11.695856220673885 2.2039640144019287e-12 8.520000985536273 18.879626236077907 0.0 14.119278321488858 0.0 0.5114410009148366 489454004.44553655 489454011.07500786 2.0143910321030064e-12 11.695856220673885 10.359625250541635 NFSDNQLQEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFSDNQLQEGK 11 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 50593300.0 1794300.0 25792000.0 23007000.0 False True 2457701.19913427 24652424.15726162 17573220.444038488 1.0 10.030684025358934 7.150267270174538 21.228878096616995 -9.219589564901936 9.999685686338498 0.9999522747462828 8.590475647767315 0.902525013162398 1.175925216452296 0.0 0.0 1.1385846947795162 0.379528231593172 6.031293112546201e-10 9.219589564901936 7.590523373021032 NFSDNQLQEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFSDNQLQEGK 11 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 18119980.0 15653000.0 1851200.0 615780.0 False True 13016163.045476062 1841227.21816557 744536.7509549694 1.0 0.14145698787981245 0.05720093919795688 23.633800892202046 -13.962758031474474 0.3283832715721171 9.99999999999876 0.04191376818846091 0.9997100804135617 0.007253024681574009 18.219817638980423 0.18297744362338833 113.03223045398457 0.02718064026030004 1.0895369631762478e-14 13.962758031474474 -9.958086231810299 NFSDNQLQEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFSDNQLQEGK 11 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 11234300.0 3703200.0 3990100.0 3541000.0 False True 4793865.4009851925 3768047.427420206 2896574.33372821 1.0 0.7860144397558243 0.6042252110651526 22.19275797183286 -6.973016067523612 0.17146152197716763 1.1574882721666564 0.2278762701648265 0.9999973609477398 0.00026270608329113536 0.07533564930098881 0.005356698356424241 0.007559139682631645 0.020959900791555273 1.0641036490232336e-07 6.973016067523612 -0.9296120020018299 NFSDNQLQEGK(ub)NVIGLQMGTNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFSDNQLQEGKNVIGLQMGTNR 22 1 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 1 10880800.0 2680400.0 5294800.0 2905600.0 True False 3514030.3570305207 4504836.47896875 2604956.3844832834 1.0 1.281957189116458 0.7413016166099837 21.74469522388851 -6.764951694363327 1.5935094144929607 1.1627591555960688 0.7388039816562184 0.7110037891601885 0.11869298400143928 0.27465930085574053 1.3755256887202474 0.05873665979118399 0.1404903075001856 1.7180994770219986e-07 6.764951694363327 -0.4239551739398504 NFSDNQLQEGK(ub)NVIGLQMGTNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFSDNQLQEGKNVIGLQMGTNR 22 1 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 1 35323100.0 14187000.0 8253100.0 12883000.0 True False 13736641.450571178 11548605.869347941 9508555.818284411 1.0 0.8407153896317024 0.6922038296259847 23.71152597878295 -6.971968484657985 0.2058126600560422 1.0820311039933281 0.44676157055063975 0.9999939358085759 0.0003094475978404177 0.07566902512468028 0.006693682020984909 0.004598735723631252 0.015542039777724986 1.0666735234598901e-07 6.971968484657985 -0.6352695334426883 NFSDNQLQEGK(ub)NVIGLQMGTNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFSDNQLQEGKNVIGLQMGTNR 22 1 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 1 103691000.0 15396000.0 36105000.0 52190000.0 True False 23356857.59836791 29661780.660347417 41874623.62431039 1.0 1.2699388406777832 1.792819237260599 24.477342853146723 -6.96066563369782 0.42594855721389063 0.9783154997494993 2.1043607182027735 0.9997940959177105 0.004722544531059773 0.07946418908734465 0.020259015570657343 0.0067935351714368975 0.04345767087998442 1.0947989350944477e-07 6.96066563369782 1.126045218453274 NFSDNQLQEGK(ub)NVIGLQMGTNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFSDNQLQEGKNVIGLQMGTNR 22 1 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 1 15013000.0 2680400.0 7330200.0 5002400.0 True False 3671416.3150863796 7006327.526270128 3820936.1476619355 1.0 1.908344607360412 1.0407253821804836 21.8079052854114 -10.320594261941233 4.611946090903654 0.999650951636056 1.4745349947715738 0.2851304933347484 0.3542040654571336 0.0012721501087587554 0.00018740591516457414 0.3432040677337416 0.11431887055566056 4.7797561212785046e-11 10.320594261941233 0.4748840431355178 NFSDNQLQEGK(ub)NVIGLQMGTNR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NFSDNQLQEGKNVIGLQMGTNR 22 1 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 1 41047400.0 17035100.0 15399900.0 8612400.0 True False 14165440.43288758 15316937.682059173 10413213.02076159 1.0 1.081289194969059 0.7351139606351718 23.755872123002348 -6.844836940081127 1.2599052654775378 1.0432539731463586 0.7226056008985972 0.9324254025766714 0.03842139233893343 0.16323062307502154 0.5012383573591862 0.023892270737597213 0.05513078222274365 1.4294305508194917e-07 6.844836940081127 -0.32064837224776144 NFSGPVPDLPEGITVAYTIPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFSGPVPDLPEGITVAYTIPK 21 0 E7EQ61;Q9GZZ9;Q9GZZ9-2 E7EQ61 UBA5 Ubiquitin-like modifier-activating enzyme 5 0 10578700.0 2743500.0 2878400.0 4956800.0 False True 2656409.094215973 4027760.130657706 3658465.3791874717 1.0 1.5162424113920154 1.37722212559555 21.341045912073863 -10.005951216965293 4.691551226909374 0.9999914478226652 1.4467322684557902 0.9322869202558759 0.05675479409080785 39138368.48653016 1.3444174399616855 4097.77147675756 0.01942867559507324 9.863902777566472e-11 10.005951216965293 0.4467408206331249 NFSGPVPDLPEGITVAYTIPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFSGPVPDLPEGITVAYTIPK 21 0 E7EQ61;Q9GZZ9;Q9GZZ9-2 E7EQ61 UBA5 Ubiquitin-like modifier-activating enzyme 5 0 7097100.0 2743500.0 2328600.0 2025000.0 False True 2281341.8076575464 2316055.369609091 2448418.1374578783 1.0 1.015216291497848 1.0732359917481562 21.12145118750814 -6.945974929060102 0.6014068245663099 0.9993484629791851 1.092081086213709 0.998846382041485 0.0010717407153421328 0.08514324682324594 0.04296876683290651 0.0010984526728333407 0.004878080434810259 1.1324657362994666e-07 6.945974929060102 0.0927326232345238 NFSK(ub)NIFAILQSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFSKNIFAILQSVK 14 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3 A0A3B3IRP5 CDC73 Parafibromin 1 10851800.0 4246100.0 3800000.0 2805700.0 True False 4111309.8796976344 5317359.816738213 2070803.000804206 1.0 1.2933493150191047 0.5036844853340277 21.971166684853983 -6.806110262409216 1.430773326954866 1.1606228258255167 0.49105889251627355 0.8494417487578436 0.126458899797773 0.21215165251041382 0.8566507609671223 0.06951158274286905 0.16109990817228748 1.5627508276815064e-07 6.806110262409216 -0.6695639333092431 NFSRPDGLEDSEDSK(ub)EDENVPTAPDPPSQHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFSRPDGLEDSEDSKEDENVPTAPDPPSQHLR 32 2 B8ZZD4;Q86VP1-3;Q86VP1-4;Q86VP1-2;Q86VP1;H7C3L5 B8ZZD4 TAX1BP1 Tax1-binding protein 1 1 19564400.0 6108400.0 7644400.0 5811600.0 True False 8008171.553829745 6503885.317637811 5210271.380803629 1.0 0.8121560925511717 0.6506193512190586 22.933041449742884 -6.972883465331953 0.1761833647702733 1.1313745889733073 0.3270490312477379 0.9999970174519434 0.0002464948448766531 0.07537766790435381 0.005532647918958097 0.006435794400494582 0.01834343228838172 1.0644285990867097e-07 6.972883465331953 -0.8043255577255695 NFSRPDGLEDSEDSK(ub)EDENVPTAPDPPSQHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFSRPDGLEDSEDSKEDENVPTAPDPPSQHLR 32 2 B8ZZD4;Q86VP1-3;Q86VP1-4;Q86VP1-2;Q86VP1;H7C3L5 B8ZZD4 TAX1BP1 Tax1-binding protein 1 1 18024400.0 5409500.0 7387500.0 5227400.0 True False 5237778.383510595 10337367.275303563 3858187.1213614778 1.0 1.973616773830548 0.7366075535970934 22.32052358820052 -6.696850011051421 1.8424136350720257 1.6064292966114497 0.7405232265223326 0.4025966631411043 0.4112154364685393 0.4020569496218602 2.651137747296743 0.17822399711626133 0.46008279510514133 2.009786797388983e-07 6.696850011051421 -0.8659060700891171 NFSRPDGLEDSEDSK(ub)EDENVPTAPDPPSQHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFSRPDGLEDSEDSKEDENVPTAPDPPSQHLR 32 2 B8ZZD4;Q86VP1-3;Q86VP1-4;Q86VP1-2;Q86VP1;H7C3L5 B8ZZD4 TAX1BP1 Tax1-binding protein 1 1 34905200.0 9865800.0 16835000.0 8204400.0 True False 12771472.583992135 15898117.45084565 6711283.384252965 1.0 1.2448147499273088 0.525490176650807 23.606421545331926 -6.814842822562382 1.3938754250159437 1.1326797148374996 0.5114360365283057 0.8721561052636393 0.10676947982710482 0.2002603029688514 0.765842750616783 0.060211839967816504 0.13901598046451719 1.5316416846046499e-07 6.814842822562382 -0.6212436783091939 NFTTEQVTAMLLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFTTEQVTAMLLSK 14 0 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 0 11728400.0 2430800.0 5360500.0 3937100.0 False True 3186802.3399006817 4560734.29506534 3529726.659329954 1.0 1.4311318395754276 1.1076076527042966 21.603678108650655 -10.424755066962316 6.667887144849552 0.999960673932399 1.269369746139862 0.480336204492794 0.13207819621385056 7.722626230476142e-05 6.662588959628502e-06 0.12790278696300217 0.04262805452777988 3.760494285355285e-11 10.424755066962316 0.26940907220746313 NFTTEQVTAMLLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFTTEQVTAMLLSK 14 0 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 0 13695100.0 0.0 2319100.0 11376000.0 False True 0.0 3245128.7239467343 8396284.327315329 0.0 NFTTEQVTAMLLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFTTEQVTAMLLSK 14 0 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 0 12599000.0 2430800.0 4331200.0 5837000.0 False True 3329532.4499000036 4139833.2626369246 4458420.816788492 1.0 1.2433677475530407 1.3390531204831453 21.666888170173547 -13.446491838198838 0.13458414054162554 3.192098857802658e-13 1.4689864185717445 0.9996346710281455 0.0027280298531982728 9.849600587915189 0.10970284878062195 2.6740690996280985 0.11223874700467612 3.5769112268902795e-14 13.446491838198838 1.4689864185714252 NFTTEQVTAMLLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFTTEQVTAMLLSK 14 0 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 0 4348300.0 0.0 1830600.0 2517700.0 False True 0.0 1820738.1944543477 3044139.4294704725 0.0 NFVNTFIQFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFVNTFIQFK 10 0 Q9Y232-2;Q9Y232;Q9Y232-3;Q9Y232-4;C9JQG7;C9JMH9;Q9Y6F8;Q9Y6F7;Q9Y6F8-2 Q9Y232-2 CDYL;CDY2A;CDY1 Chromodomain Y-like protein;Testis-specific chromodomain protein Y 1;Testis-specific chromodomain protein Y 2 0 20148300.0 5988000.0 6390800.0 7769500.0 False True 7850325.987874485 5437317.551143292 6965586.670306601 1.0 0.69262315469978 0.8872990345962141 22.904321133051376 -10.623014488118956 5.843021762714133 1.0013169375959254 0.789961094647997 0.6081626610766122 0.07947609516226758 0.0013715750524297067 8.849232173458672e-05 0.07741065216143896 0.025650799415421515 2.3822399962048954e-11 10.623014488118956 -0.21135584294792842 NFVNTFIQFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFVNTFIQFK 10 0 Q9Y232-2;Q9Y232;Q9Y232-3;Q9Y232-4;C9JQG7;C9JMH9;Q9Y6F8;Q9Y6F7;Q9Y6F8-2 Q9Y232-2 CDYL;CDY2A;CDY1 Chromodomain Y-like protein;Testis-specific chromodomain protein Y 1;Testis-specific chromodomain protein Y 2 0 21019200.0 5697300.0 9514100.0 5807800.0 False True 8643220.628421761 7816234.520997415 4659885.784350826 1.0 0.9043196809410439 0.5391376646139964 23.043137557509148 -6.94595327350198 0.6016339885486142 1.0040989188873028 0.420612100048414 0.9988442270804654 0.006751059810389216 0.0851525626903389 0.04300933079839504 0.006917779906395587 0.030705407700024317 1.1325222067130672e-07 6.94595327350198 -0.5834868188388889 NFVNTFIQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFVNTFIQFK 10 0 Q9Y232-2;Q9Y232;Q9Y232-3;Q9Y232-4;C9JQG7;C9JMH9;Q9Y6F8;Q9Y6F7;Q9Y6F8-2 Q9Y232-2 CDYL;CDY2A;CDY1 Chromodomain Y-like protein;Testis-specific chromodomain protein Y 1;Testis-specific chromodomain protein Y 2 0 25630600.0 5988000.0 7295600.0 12347000.0 False True 8201925.41961545 6973256.26867703 9430892.894447045 1.0 0.8501974733883856 1.1498388990336876 22.967531194574267 -6.7707928875934495 1.571589823831318 0.9141637845846403 1.151568126413813 0.7335245290797914 0.06314730906624019 0.265148768836545 1.2925849654964037 0.031670315162662145 0.07532852083857301 1.6951460125769164e-07 6.7707928875934495 0.23740434182917258 NFVNTFIQFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFVNTFIQFK 10 0 Q9Y232-2;Q9Y232;Q9Y232-3;Q9Y232-4;C9JQG7;C9JMH9;Q9Y6F8;Q9Y6F7;Q9Y6F8-2 Q9Y232-2 CDYL;CDY2A;CDY1 Chromodomain Y-like protein;Testis-specific chromodomain protein Y 1;Testis-specific chromodomain protein Y 2 0 23364600.0 5697300.0 10355000.0 7312300.0 False True 7375267.160572733 9778735.147223437 5981536.430533963 1.0 1.3258821591574808 0.8110264076277153 22.814263879601597 -6.735632890284584 1.7027483656189941 1.1948612949467552 0.8110020258054479 0.5853011867602064 0.13694154412839768 0.32570117818471744 1.8524186868195178 0.06367056821061179 0.15699329668284528 1.8380914280242005e-07 6.735632890284584 -0.3838592691413073 NFVVVMVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFVVVMVTK 9 0 P54727;Q5W0S5;Q5W0S4;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 0 47354900.0 0.0 19754000.0 27600900.0 False True 0.0 16228744.361293562 22145570.0170958 0.0 NFVVVMVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFVVVMVTK 9 0 P54727;Q5W0S5;Q5W0S4;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 0 21766000.0 0.0 21766000.0 0.0 False True 0.0 20554702.966148257 0.0 0.0 NFVVVMVTK(ub)PK ddPTM_RPMI8226_Bortezomib_1h_R1 2 NFVVVMVTKPK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 67214100.0 26358600.0 33975300.0 6880200.0 True False 34556379.857045494 28906317.674682114 6168302.903538636 1.0 0.8364972776159763 0.17849968454612347 25.042448752203434 -6.984790313798907 0.6347395084578022 1.00552020506202 4.7506636940145485e-20 0.9986957103429682 0.012822680959914819 0.07911807080104416 0.04659824472425323 0.013010745092940852 0.050808015147604385 1.0356420750256207e-07 6.984790313798907 -1.00552020506202 down NFVVVMVTK(ub)PK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFVVVMVTKPK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 91688600.0 37013200.0 43642400.0 11033000.0 True False 35838236.22600139 61069037.91210939 8143126.317094759 1.0 1.704019068544521 0.22721894754370614 25.094996301310854 -6.77706475859668 1.547257529704404 1.4001492798717727 0.21656842532814208 0.7568920639566394 0.29737368076116244 0.2551571852751318 1.206315195027041 0.15140738085180738 0.3581517343785944 1.6708414529242628e-07 6.77706475859668 -1.1835808545436306 NFVVVMVTK(ub)PK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFVVVMVTKPK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 123778500.0 68518500.0 35213000.0 20047000.0 True False 103947573.87332891 28928965.029575244 16084701.663087754 1.0 0.2783034173056145 0.1547385962339887 26.631280845320546 -13.999999999999998 0.24829003061783578 5.9761315928234024 0.1042406875698348 0.9995395047993425 0.007999210223263511 13.930852711202625 0.15767841012482867 34.53915123488998 0.05757172820463176 1.0000000000000041e-14 13.999999999999998 -5.871890905253568 NFVVVMVTK(ub)PK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NFVVVMVTKPK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 71190900.0 26358600.0 36351200.0 8481100.0 True False 36104086.7343814 34745083.78665668 6478038.853737342 1.0 0.9623587501957067 0.17942674748696522 25.105658813726325 -6.916917338353397 0.8472783364692014 1.0192678226143488 0.061710836777900645 0.9932807887433124 0.03100644337987839 0.10001979541258384 0.1152650640288726 0.026287931971320715 0.07656637241460724 1.2108285752514654e-07 6.916917338353397 -0.9575569858364481 down NFVVVMVTK(ub)PK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFVVVMVTKPK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 92771900.0 37013200.0 50464000.0 5294700.0 True False 30778115.762781274 50192140.41568028 6401797.290073203 1.0 1.6307736575731384 0.2079983498474795 24.87540157674513 -6.786151851882646 1.5114622132698146 1.3542928616137961 0.19437248406283297 0.7887387419829468 0.2675457915585344 0.24110166257785667 1.0881209647743657 0.13935719612772196 0.3272365956326987 1.6362443054957296e-07 6.786151851882646 -1.1599203775509632 NFVVVMVTK(ub)PK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFVVVMVTKPK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 124948500.0 68518500.0 40237000.0 16193000.0 True False 88698548.95155653 37997775.578834325 13246040.154210938 1.0 0.42839230210617235 0.1493377322490966 26.402407167412996 -9.046592133100726 0.27331788630460685 1.2916486953110475 1.1231956003466403e-23 0.9989110612273624 0.01168368508809146 0.5011151225106351 0.09507017825958837 0.24610197769712464 0.1036086729925371 8.98272009065361e-10 9.046592133100726 -1.2916486953110475 NFVVVMVTK(ub)TK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFVVVMVTKTK 11 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 7494300.0 2769500.0 3100000.0 1624800.0 True False 3630841.31987615 2637492.083705354 1456681.2821821414 1.0 0.7264134814339174 0.4011966246522251 21.79187245015628 -6.968833979498089 0.284661057140027 1.0677428368099726 0.04989356396271918 0.9999718050080392 0.0012996540533603887 0.07668290555707459 0.01037796867011778 0.005850385433743776 0.02967920928097813 1.0744000515591212e-07 6.968833979498089 -1.0178492728472535 down NFVVVMVTK(ub)TK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFVVVMVTKTK 11 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 63862000.0 22651000.0 28185000.0 13026000.0 True False 21931956.40353054 39439417.48283325 9614099.828376368 1.0 1.7982626245091573 0.4383603382883215 24.38653117516421 -6.747563676120613 1.65844985490363 1.470729600407942 0.4360772517991192 0.6386651579893934 0.3354034026288842 0.30427548026347706 1.6457471869947102 0.1598003454628223 0.38901220972481304 1.7882833123472506e-07 6.747563676120613 -1.0346523486088228 NFVVVMVTKPK ddPTM_RPMI8226_Bortezomib_1h_R1 2 NFVVVMVTKPK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 0 77406500.0 34268700.0 21285800.0 21852000.0 False True 44926597.55856291 18110041.61139854 19590964.659185234 1.0 0.4031028966258053 0.4360660660680555 25.42106647009116 -9.954441748173242 5.247098801675037 1.000001800210833 0.41958448134400844 0.9975868076726131 0.01345715758634827 36929380.908157796 35.28068011781856 845.4689237280371 0.004606742979180743 1.1106014900861258e-10 9.954441748173242 -0.5804173188668247 NFVVVMVTKPK ddPTM_RPMI8226_Bortezomib_2h_R1 2 NFVVVMVTKPK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 0 64938000.0 25953700.0 13925100.0 25059200.0 False True 25129813.999837104 19485465.048437163 18495443.760114335 1.0 0.7753923307416232 0.735996046776718 24.58289665725638 -13.999999999999998 0.2448597798170823 2.522473433893675 0.7193624246692831 0.9995332961120309 0.0025121258019886964 13.799997117245445 0.15659460261401442 10.30261139223762 0.018715756527143336 1.0000000000000041e-14 13.999999999999998 -1.8031110092243918 NFVVVMVTKPK ddPTM_RPMI8226_Bortezomib_8h_R1 2 NFVVVMVTKPK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 0 102561600.0 34399700.0 31945700.0 36216200.0 False True 52186859.85493475 26244740.242106687 29058052.195875637 1.0 0.5028993948871404 0.5568078301060669 25.637183260115044 -10.454401480750446 5.179476644613209 1.0007019696177495 0.529853612496593 0.9902355663420622 0.022008026519745913 0.00017865052354373723 1.8818706253970215e-05 0.02133948684594458 0.007103060016150237 3.512355929069521e-11 10.454401480750446 -0.47084835712115647 NFVVVMVTKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NFVVVMVTKPK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 0 92666700.0 34268700.0 29095300.0 29302700.0 False True 46938764.46679632 27809773.440709356 22382005.768050034 1.0 0.5924692257373223 0.4768341481140323 25.48427653161405 -13.999999999999995 0.17668292010534206 3.0936089198242116 0.38176357802366656 0.999502515726791 0.005004856986022448 12.163609082881129 0.13321458915183118 8.73622339197905 0.08883419648028758 1.0000000000000123e-14 13.999999999999995 -2.711845341800545 NFVVVMVTKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NFVVVMVTKPK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 0 47128900.0 25953700.0 10289200.0 10886000.0 False True 21581651.493858814 10233770.0373537 13162212.268822944 1.0 0.4741884577399361 0.609879752370588 24.363301932690657 -10.261972276089331 8.35307873470513 1.0000003133498212 0.5420341050553193 0.9382259057201044 0.055395739063791985 3.232991793317859e-07 2.8513622580724374e-08 0.053636730474735626 0.017878897903743172 5.4705088368248484e-11 10.261972276089331 -0.45796620829450185 NFVVVMVTKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NFVVVMVTKPK 11 1 P54727;Q5W0S5;Q5W0S4 P54727 RAD23B UV excision repair protein RAD23 homolog B 0 112844300.0 34399700.0 49379300.0 29065300.0 False True 44531089.7694616 46631298.54710673 23775713.635162562 1.0 1.047162752776048 0.5339126834364472 25.408309582207494 -6.8844303096438635 1.0547418482604825 1.0313706529876472 0.4942956814839516 0.977088437417862 0.035061380060044375 0.12377981518681168 0.24916405612811596 0.025495216318058896 0.06241214491153072 1.3048773428655658e-07 6.8844303096438635 -0.5370749715036955 NFVVVMVTKTK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFVVVMVTKTK 11 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 19171700.0 15008000.0 0.0 4163700.0 True False 20556863.175950035 0.0 3180319.814093234 1.0 0.0 0.15470841961014586 24.29311680103123 -10.195643398020808 4.203406738867522 1.0003826529751019 0.07735420974830325 0.9793482754665357 0.06315944805143318 184476240.4276244 369342485.1677832 947150.1411788068 0.023266817657700157 6.373186125140723e-11 10.195643398020808 -0.9230284432267987 NFWVSGLSSTTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NFWVSGLSSTTR 12 0 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 0 57448000.0 17238000.0 15251000.0 24959000.0 False True 22599184.93302947 12975610.24793239 22376482.103633717 1.0 0.5741627534968351 0.9901455371042933 24.42976740524664 -10.820410553295336 10.250997437361672 1.0031417983536695 0.782154145949889 0.2677574598099113 0.16982426027014388 0.012302328921227875 0.0002155267140960872 0.16589235609904554 0.05481054431735513 1.5121311037704074e-11 10.820410553295336 -0.2209876524037805 NFWVSGLSSTTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFWVSGLSSTTR 12 0 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 0 47202400.0 13700000.0 8041400.0 25461000.0 False True 13265100.999000851 11252372.955347018 18792000.286372703 1.0 0.8482689243146031 1.4166496197645344 23.661132324339242 -6.835682015755484 1.3023272553070355 0.9191859646792567 1.433798211475029 0.9167661323866413 0.06932582474429562 0.1739038366074988 0.5748039389629886 0.041768739370056034 0.0961426222783123 1.4598827744618876e-07 6.835682015755484 0.5146122467957722 NFWVSGLSSTTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFWVSGLSSTTR 12 0 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 0 23440000.0 0.0 14206000.0 9234000.0 False True 0.0 11670828.308015378 7408895.85259402 0.0 NFWVSGLSSTTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFWVSGLSSTTR 12 0 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 0 47986000.0 17238000.0 15476000.0 15272000.0 False True 23611354.439434074 14792219.147711761 11665068.136713 1.0 0.6264875310586505 0.4940448531504317 24.49297746676953 -13.999999999999998 0.14443949898152586 2.7924323808268245 0.3385868122941594 0.9995858428088865 0.00435972128806892 11.941143505399115 0.11937795429872113 6.019319984290564 0.13943327860001206 1.0000000000000041e-14 13.999999999999998 -2.4538455685326652 NFWVSGLSSTTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NFWVSGLSSTTR 12 0 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 0 37977000.0 13700000.0 10438000.0 13839000.0 False True 11392157.012906283 10381768.422219222 16732670.915693628 1.0 0.9113084037077104 1.468788649659325 23.44153759977352 -6.866185905277328 1.1541495206902832 0.9508328277711812 1.4991463629537185 0.9607223285080045 0.04847406794661809 0.14056064097445525 0.35235044264437776 0.032666349544544004 0.07686295206046315 1.3608620234678507e-07 6.866185905277328 0.5483135351825373 NFWVSGLSSTTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFWVSGLSSTTR 12 0 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 0 14380000.0 0.0 14380000.0 0.0 False True 0.0 13579740.35896407 0.0 0.0 NFYGGNGIVGAQVPLGAGIALACK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NFYGGNGIVGAQVPLGAGIALACK 24 0 P08559;P08559-4;P08559-2;Q5JPT9 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 0 82644000.0 10067000.0 39531000.0 33046000.0 False True 15272374.996282773 32476384.192887284 26514443.61542367 1.0 2.126478966158956 1.7361048050402876 23.8644210962826 -10.11369625158452 4.5770765681795265 0.999934509417169 1.9312918854740704 0.8835634098092187 0.15936958427430448 25012153.421202596 27633959.36858382 16935.9063115838 0.054556447944306176 7.696685633338919e-11 10.11369625158452 0.9313573760569014 NFYGGNGIVGAQVPLGAGIALACK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NFYGGNGIVGAQVPLGAGIALACK 24 0 P08559;P08559-4;P08559-2;Q5JPT9 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 0 12691700.0 2058800.0 3225900.0 7407000.0 False True 2819993.996978008 3083369.0713752434 5657619.1519534495 1.0 1.0933956152670807 2.0062521969962797 21.427260660835024 -6.926570134176182 0.7744176321136358 0.9842126320209643 2.178281261887997 0.9958204828745842 0.029347005971176048 0.0944575668015007 0.08669099083093917 0.0262102379110693 0.08420860931042329 1.1842131130874146e-07 6.926570134176182 1.1940686298670329 up NFYGGNGIVGAQVPLGAGIALACK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NFYGGNGIVGAQVPLGAGIALACK 24 0 P08559;P08559-4;P08559-2;Q5JPT9 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 0 38244000.0 10067000.0 16243000.0 11934000.0 False True 13031929.950237073 15339062.771255476 9762134.453180596 1.0 1.1770369262134066 0.749093533379759 23.63554741837505 -6.794351763105088 1.478779380378145 1.0983905315280045 0.7439731888281811 0.815138743341643 0.07548831253401889 0.22893220020580074 0.9888240498862096 0.040169940879772104 0.09376342364167793 1.605640214641773e-07 6.794351763105088 -0.3544173426998234 NFYQEHPDLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFYQEHPDLAR 11 0 J3KTA4;P17844;P17844-2;J3QRQ7;J3QR02;J3KRX8;J3KTQ4;X6RLV5 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 12787800.0 3473500.0 1207000.0 8107300.0 False True 3363235.6437977687 1688961.394421849 5983754.916213398 1.0 0.5021834843884659 1.7791661215437573 21.68141843359709 -6.80099196611132 1.4519798357095617 0.7256785162147614 1.7972052561515774 0.8350171765805573 0.21345888489462206 0.21934359749466292 0.9128644794144409 0.11565159216872029 0.2687875422485792 1.581277290593514e-07 6.80099196611132 1.071526739936816 NFYVEHPEVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NFYVEHPEVAR 11 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 NGCLCCSVK(ub)DNGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NGCLCCSVKDNGLR 14 1 Q8IUF1;C9J3G2 Q8IUF1 CBWD2 COBW domain-containing protein 2 1 27855800.0 3477800.0 3487000.0 20891000.0 True False 4502080.6576869525 3292945.3846806535 17089052.359761667 1.0 0.7314274521177682 3.7958121275733787 22.102160473162577 -6.885550193829511 1.0483946247017368 0.8173565050119079 4.0374548306465465 0.9778921096657928 0.20602199324440076 0.12282581986703002 0.24355754283292863 0.1505436046465026 0.3697568703111021 1.3015168833389697e-07 6.885550193829511 3.2200983256346385 up NGDVCISILHEPGEDK(ub)YGYEKPEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGDVCISILHEPGEDKYGYEKPEER 25 2 P62253;I3L2H7;K7EPR7 P62253 UBE2G1 Ubiquitin-conjugating enzyme E2 G1;Ubiquitin-conjugating enzyme E2 G1, N-terminally processed 1 50136000.0 14992000.0 15862000.0 19282000.0 True False 19654657.182734516 13495451.429591738 17286883.60600446 1.0 0.6866286857166206 0.8795311688870358 24.228367864652146 -10.319718664192129 5.777544109101318 1.0000254649759512 0.7830799283256732 0.6277018769059305 0.07875210898055958 2.5834628910902553e-05 3.0419244410570566e-06 0.07626034376644102 0.025417133880034384 4.789402491717609e-11 10.319718664192129 -0.21694553665027805 NGDVCISILHEPGEDK(ub)YGYEKPEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGDVCISILHEPGEDKYGYEKPEER 25 2 P62253;I3L2H7;K7EPR7 P62253 UBE2G1 Ubiquitin-conjugating enzyme E2 G1;Ubiquitin-conjugating enzyme E2 G1, N-terminally processed 1 41144100.0 19101000.0 14019000.0 8024100.0 True False 18494649.210358795 19616859.808119204 5922347.492159901 1.0 1.0606775822020924 0.32021950915634634 24.140604601208985 -6.8870341268854665 1.0398036082274986 1.0426605102332462 0.26012249177669516 0.9789297178889493 0.048724349811454515 0.12158104314728743 0.2361867990012257 0.03583685789713762 0.08843636967629653 1.297077342566759e-07 6.8870341268854665 -0.7825380184565511 down NGDVCISILHEPGEDK(ub)YGYEKPEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGDVCISILHEPGEDKYGYEKPEER 25 2 P62253;I3L2H7;K7EPR7 P62253 UBE2G1 Ubiquitin-conjugating enzyme E2 G1;Ubiquitin-conjugating enzyme E2 G1, N-terminally processed 1 65285000.0 14992000.0 21477000.0 28816000.0 True False 20534947.54356627 20528075.12505846 22010254.284148872 1.0 0.9996653306031958 1.0718437063183452 24.291577926175037 -6.905854331574978 0.9234891332771835 0.9974617838290359 1.0803899322640163 0.9892611866224637 0.003517822472517692 0.1072241666197518 0.15410408761127456 0.0028223121023027093 0.0075844016181499194 1.24206884494226e-07 6.905854331574978 0.08292814843498031 NGDVCISILHEPGEDK(ub)YGYEKPEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGDVCISILHEPGEDKYGYEKPEER 25 2 P62253;I3L2H7;K7EPR7 P62253 UBE2G1 Ubiquitin-conjugating enzyme E2 G1;Ubiquitin-conjugating enzyme E2 G1, N-terminally processed 1 44992000.0 19101000.0 13745000.0 12146000.0 True False 15883327.81777541 13670952.956831114 14685672.443241166 1.0 0.8607108732926626 0.9245966973499143 23.92100987664326 -10.129596903344426 4.542703933845378 1.000011934465924 0.8926537853185643 0.7901128146550822 0.026081278465529923 3.1527967830681328e-06 6.040930579495776e-07 0.025255896370812273 0.008417696427427086 7.419986184534487e-11 10.129596903344426 -0.10735814914735964 NGEDLGVAFWISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NGEDLGVAFWISK 13 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 21746500.0 3347600.0 9928300.0 8470600.0 False True 5078553.942341936 8156517.294838049 6796382.197204127 1.0 1.6060708200485776 1.33825145393061 22.275986334589902 -10.034687953499448 4.445640180522202 0.9999766764084076 1.472161136963115 0.8056043477849938 0.10933679854537931 76213467.44197153 102691153.00348128 24104.337830146145 0.040013165158636295 9.232345454923004e-11 10.034687953499448 0.4721844605547073 NGEDLGVAFWISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NGEDLGVAFWISK 13 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 12838400.0 3347600.0 6697900.0 2792900.0 False True 4333534.191061256 6325155.9770727 2284620.857573995 1.0 1.4595837250158414 0.527195761437965 22.04711265668235 -6.772726275263283 1.5645071620128987 1.2626919250397122 0.5214633230979503 0.7407015965322159 0.19383647639573606 0.2620466021429319 1.2662784377062692 0.0976460494223554 0.23181520344525572 1.6876163518093194e-07 6.772726275263283 -0.7412286019417619 NGENGIHFLLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGENGIHFLLNR 12 0 H0Y8R1;F5H5I6;H0YAK1;Q12849-5;Q12849 H0Y8R1 GRSF1 G-rich sequence factor 1 0 13425800.0 3821700.0 4835500.0 4768600.0 False True 5010285.709395445 4114062.2486313763 4275191.015641164 1.0 0.8211232826336745 0.8532828791827564 22.256461444156873 -10.064407022302323 4.941366194423504 1.0000038773827153 0.837203080907017 0.9715644404292353 0.013129100317354177 5.608299195784303e-07 1.0619256940416761e-07 0.012712499402499619 0.004237398906052431 8.621701401441872e-11 10.064407022302323 -0.16280079647569834 NGENGIHFLLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGENGIHFLLNR 12 0 H0Y8R1;F5H5I6;H0YAK1;Q12849-5;Q12849 H0Y8R1 GRSF1 G-rich sequence factor 1 0 9816800.0 3040700.0 1617000.0 5159100.0 False True 2944174.642895033 2262676.5325436 3807776.9403175614 1.0 0.7685266015057756 1.293325771114359 21.48943182121015 -6.78685702542161 1.5093284445653188 0.8700972171529808 1.2983984992970967 0.7908281505853987 0.09821374211032699 0.24007488109307173 1.080539424028855 0.05123320137167042 0.12020618957351396 1.6335896552809215e-07 6.78685702542161 0.4283012821441159 NGENGIHFLLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGENGIHFLLNR 12 0 H0Y8R1;F5H5I6;H0YAK1;Q12849-5;Q12849 H0Y8R1 GRSF1 G-rich sequence factor 1 0 13400900.0 3821700.0 3237600.0 6341600.0 False True 5234685.76755918 3094552.126688519 4843844.689351694 1.0 0.5911629205837586 0.925336286538986 22.319671505679764 -9.958659266784684 6.73637682276222 1.0000000233616548 0.7582496035613706 0.41100163454370353 0.13642570536978277 4.783177836842619e-08 7.3049234780048964e-09 0.13209363303301241 0.0440312070743131 1.0998684217238776e-10 9.958659266784684 -0.24175041980028422 NGENGIHFLLNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGENGIHFLLNR 12 0 H0Y8R1;F5H5I6;H0YAK1;Q12849-5;Q12849 H0Y8R1 GRSF1 G-rich sequence factor 1 0 6640400.0 3040700.0 2056300.0 1543400.0 False True 2528476.775849941 2045222.3037564065 1866117.8041246852 1.0 0.8088752577404671 0.7380403181664164 21.269837096644427 -13.999999999999998 0.1378808139667809 1.9114065528887834 0.6480992338863366 0.9996115140463385 0.002180694586357589 11.932438355006973 0.1161793417206376 2.929707586212783 0.0802971599741233 1.0000000000000041e-14 13.999999999999998 -1.2633073190024469 NGENGIHFLLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NGENGIHFLLNR 12 0 H0Y8R1;F5H5I6;H0YAK1;Q12849-5;Q12849 H0Y8R1 GRSF1 G-rich sequence factor 1 0 7466900.0 2826200.0 4640700.0 0.0 False True 3658571.6127307033 4382440.965496849 0.0 1.0 1.1978557287897011 0.0 21.80284906770937 -6.916578832505252 1.2657129488109566 1.103937813241512 1.4944591497932636e-18 0.9573048452059754 0.10833489036959389 0.1242420678632543 0.39854038484315507 0.07031625073337697 0.13777809021090417 1.2117727095834613e-07 6.916578832505252 -1.103937813241512 down NGETELCMEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGETELCMEGR 11 0 O95433;G3V438;H0YJU2 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 0 2476800.0 0.0 2476800.0 0.0 False True 0.0 2107271.0944907838 0.0 0.0 NGFLLDGFPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGFLLDGFPR 10 0 P54819;F8W1A4;P54819-2;P54819-5;P54819-3;F8VZG5;A0A5F9ZHP2;A0A5K1VW67;P54819-6;F8VY04;G3V213;P54819-4 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 0 9413000.0 1119200.0 4345800.0 3948000.0 False True 1467282.0383482187 3697423.579795723 3539498.8318901397 1.0 2.5199133385140247 2.412282532862396 20.48471477927035 -10.12646107868578 4.563066469727405 0.9998509092900287 2.466097935724306 0.9959741595215812 0.0439400925474401 15333117.135206517 7.428356456410931 24392.128968498513 0.015041862395976269 7.473756107216496e-11 10.12646107868578 1.4662470264342773 NGFLLDGFPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGFLLDGFPR 10 0 P54819;F8W1A4;P54819-2;P54819-5;P54819-3;F8VZG5;A0A5F9ZHP2;A0A5K1VW67;P54819-6;F8VY04;G3V213;P54819-4 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 0 5068300.0 2741900.0 0.0 2326400.0 False True 2654859.8853401802 0.0 1717046.0494959916 1.0 0.0 0.6467558077084652 21.34020429172498 -10.28675517510004 7.4531291779863835 1.0000032691914973 0.32337790385423265 0.593383470155334 0.2640369528445558 1.4343123806713094e-05 1.3729098323232383e-06 0.25565391376282987 0.08521756009585982 5.1670757082898934e-11 10.28675517510004 -0.6766253653372647 NGFLLDGFPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGFLLDGFPR 10 0 P54819;F8W1A4;P54819-2;P54819-5;P54819-3;F8VZG5;A0A5F9ZHP2;A0A5K1VW67;P54819-6;F8VY04;G3V213;P54819-4 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 0 8486900.0 1119200.0 3752900.0 3614800.0 False True 1532998.485242756 3587084.4688192974 2761058.6891428865 1.0 2.33991390294901 1.8010837686546457 20.547924840793243 -10.05203819076188 5.642985873774621 0.9999952109394241 2.0704988358021534 0.840324080525858 0.21997648117723845 1.3253567794052352e-05 2.226141208466642e-06 0.21299226334056398 0.07099710401289545 8.870780012048742e-11 10.05203819076188 1.0705036248627293 NGFVVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGFVVLK 7 0 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 38455900.0 9006900.0 17131000.0 12318000.0 False True 11808133.122943673 14575121.576114994 11043451.522599483 1.0 1.2343290361280694 0.9352411094639183 23.493277555519914 -6.697709883732115 1.8388855704209917 1.1458335827666375 0.9361639347144198 0.406766431525599 0.09895522881125939 0.40031562838458684 2.630059548885676 0.042955442640864996 0.11078962843872313 2.0058114968892204e-07 6.697709883732115 -0.20966964805221766 NGFVVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGFVVLK 7 0 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 25915900.0 11571000.0 5651100.0 8693800.0 False True 11203684.93864519 7907613.700097186 6416632.97159055 1.0 0.7058047190189389 0.5727252244890852 23.41746998295391 -13.999999999998376 0.10698443919065367 2.4277408355615426 0.3176453526415394 0.99975839242688 0.0027748619903622362 12.03117569655679 0.09874687792860679 3.732297759421318 0.22676681402184454 1.0000000000037384e-14 13.999999999998376 -2.1100954829200034 NGFVVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGFVVLK 7 0 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 38868900.0 9006900.0 13726000.0 16136000.0 False True 12336994.332320377 13119539.934187872 12325009.131351547 1.0 1.0634308147339735 0.9990285153218048 23.556487617042805 -6.6496701843168715 2.009675174179048 1.0411718829899597 0.9992993032187306 0.19265506064458493 0.02707536365921672 0.50939274614575 3.9430606571411952 0.01092759532010401 0.029989537795427342 2.240421933331624e-07 6.6496701843168715 -0.041872579771229046 NGGHFVISIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGGHFVISIK 10 0 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 80182000.0 14915000.0 16079000.0 49188000.0 False True 19553709.437065486 13680075.875451094 44098497.60461298 1.0 0.6996153808811084 2.2552497134390803 24.220938984215536 -6.8566534753497494 1.2025477009314092 0.8382628823949826 2.325897749698536 0.9494372113754862 0.15150853807443962 0.15029158029976677 0.41491001521624615 0.0983907286413601 0.2288733793953945 1.3910621204576255e-07 6.8566534753497494 1.4876348673035533 up NGGHFVISIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGGHFVISIK 10 0 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 67468600.0 13548000.0 8159600.0 45761000.0 False True 13117926.15580025 11417770.831751864 33774821.29942658 1.0 0.8703945041422084 2.574707381203898 23.645036323098147 -6.888559170672488 1.030895056873195 0.905236771357143 2.7172077148014346 0.9799589605410155 0.10966885885576809 0.120318875718625 0.22875198561481197 0.0812085502283489 0.20142707546569402 1.2925305873226922e-07 6.888559170672488 1.8119709434442917 up NGGHFVISIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NGGHFVISIK 10 0 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 294563000.0 32813000.0 112490000.0 149260000.0 False True 49779719.95162683 92415280.6116184 119758695.57701805 1.0 1.8564845423281298 2.4057727864558682 25.569054778308395 -8.503264133949944 0.15182528900535655 1.8707167745998838e-16 3.399048749017672 0.9998916639565852 0.006020811862522398 0.15766165185772288 0.03832425684131123 0.41206758968958557 0.3559450446162548 3.1385992457940782e-09 8.503264133949944 3.399048749017672 NGGHFVISIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGGHFVISIK 10 0 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 110135000.0 14915000.0 15455000.0 79765000.0 False True 20429478.562719543 14772146.997149447 60926149.81174119 1.0 0.723079982281398 2.9822665137876525 24.284149045738427 -6.876225844010163 1.1005892976505491 0.8355985051823214 3.131248952314445 0.97051344630853 0.17276257948762413 0.1310278037616587 0.2929114449024021 0.12129874179209507 0.2907267659978797 1.3297627282149283e-07 6.876225844010163 2.2956504471321235 up NGGHFVISIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGGHFVISIK 10 0 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 40174600.0 13548000.0 5726600.0 20900000.0 False True 11265762.278164543 5695749.669158898 25270093.369318336 1.0 0.5055804950010777 2.243087750777165 23.425441598532423 -6.830678524746197 1.3250019948379212 0.7359461272594621 2.2904516365387764 0.9072025276926434 0.22266828764668983 0.17997552559764618 0.6177366729972954 0.13194247487792365 0.3036117256133833 1.4767992912494632e-07 6.830678524746197 1.5545055092793143 up NGGHFVISIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NGGHFVISIK 10 0 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 303873000.0 32813000.0 164710000.0 106350000.0 False True 42477075.34092874 155543743.70827356 86995391.2431502 1.0 3.6618279968630407 2.048055110784096 25.340181100400844 -9.844962456144843 6.458145197207596 0.9999999361462414 2.854941553823825 0.6378948361776993 0.6588200219395846 6.111702568749529e-07 1.0891720308038006e-07 0.6378997622898872 0.21263324775986564 1.4290174887628455e-10 9.844962456144843 1.854941617677584 NGGK(ub)NFPAIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGGKNFPAIFR 11 1 Q9UBP6;H0YIH0 Q9UBP6 METTL1 tRNA (guanine-N(7)-)-methyltransferase 1 3750800.0 1261200.0 1323700.0 1165900.0 True False 1653445.413478173 1126209.1197421874 1045263.8521025121 1.0 0.6811286968180607 0.6321731842986605 20.65704398678893 -13.999999999999998 0.2638081749243222 3.3813764928327177 0.614922337296062 0.9995701974222064 0.0033810329268691174 14.588799713816364 0.1625496687124298 18.563178904012837 0.020981704393700992 1.0000000000000041e-14 13.999999999999998 -2.7664541555366555 NGGK(ub)NFPAIFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGGKNFPAIFR 11 1 Q9UBP6;H0YIH0 Q9UBP6 METTL1 tRNA (guanine-N(7)-)-methyltransferase 1 9568100.0 2398600.0 5988800.0 1180700.0 True False 1994542.175996861 5956537.145716271 1427578.9110600073 1.0 2.98641824544985 0.7157426542492196 20.927626199872932 -6.675529344074557 1.9174805174337952 2.2618020738818356 0.724588025594799 0.30394816708081274 0.842719445897867 0.44850746020223164 3.1841479520214393 0.3531399876823017 0.9368512096987301 2.1109145623430436e-07 6.675529344074557 -1.5372140482870367 NGGLGHMNIALLSDLTK ddPTM_RPMI8226_Bortezomib_1h_R1 2 NGGLGHMNIALLSDLTK 17 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 56551200.0 17504700.0 24245500.0 14801000.0 False True 22948831.21575591 20628165.908218786 13269534.501217313 1.0 0.8988765359891692 0.5782226718416443 24.451917343246212 -6.950198669192055 0.5566572893256148 1.0042694161987515 0.4575928730820689 0.9992167879970167 0.005031767528947944 0.08340604741548265 0.0356328271230874 0.005415807335593819 0.02663609551973698 1.1215053012886517e-07 6.950198669192055 -0.5466765431166827 NGGLGHMNIALLSDLTK ddPTM_RPMI8226_Bortezomib_2h_R1 2 NGGLGHMNIALLSDLTK 17 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 76207700.0 36427900.0 17854200.0 21925600.0 False True 35271516.25412429 24983475.168423016 16182627.606099235 1.0 0.7083187178124701 0.4588015862291433 25.0720002599725 -7.097914026270416 0.184002966348833 1.1913872871851883 1.4616281167683794e-12 0.9999955876696497 0.0004645369485047553 0.07633545498940679 0.006544735506436241 0.010969984852040782 0.029519723315060104 7.98152675392398e-08 7.097914026270416 -1.1913872871837266 down NGGLGHMNIALLSDLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NGGLGHMNIALLSDLTK 17 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 81407000.0 11398000.0 46751000.0 23258000.0 False True 17291599.30541683 38407918.78276975 18661046.105656467 1.0 2.2211894981129907 1.079197231907325 24.043567974677476 -6.630342676827614 2.0793196386878545 1.804337556864124 1.0838039675877773 0.11871785367832799 0.5237798378144355 0.5580855376728003 4.598741410353762 0.20600063628893978 0.5801829344991268 2.3423798485786767e-07 6.630342676827614 -0.7205335892763467 NGGLGHMNIALLSDLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NGGLGHMNIALLSDLTK 17 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 98466600.0 17504700.0 32819200.0 48142700.0 False True 23976660.63673054 31369139.22541878 36772385.79002968 1.0 1.308319773995695 1.5336741987204423 24.515127404769103 -6.9745450641444275 0.10222353774829439 0.4632128977510877 2.3845045906452427 0.999999719803757 0.00011564677587474916 0.07485388077833442 0.0030051206981755825 0.01975071617790301 0.03635557141961362 1.0603639050346099e-07 6.9745450641444275 1.921291692894155 NGGLGHMNIALLSDLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NGGLGHMNIALLSDLTK 17 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 64189300.0 36427900.0 15147700.0 12613700.0 False True 30291412.879594784 15066096.333516948 15251166.350840716 1.0 0.4973718589292323 0.5034815117889191 24.852405535406778 -9.861625733529916 6.207614584616374 1.0000000428558913 0.500426685358917 0.9998878370347298 0.0024942553358613864 1.4815770884281877e-09 2.6667347702102986e-10 0.0024150525599168837 0.0008050174479984352 1.375226607821594e-10 9.861625733529916 -0.4995733574969743 NGGLGHMNIALLSDLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NGGLGHMNIALLSDLTK 17 0 P30048-2;P30048 P30048-2 PRDX3 Thioredoxin-dependent peroxide reductase, mitochondrial 0 93737400.0 15607200.0 47077100.0 31053100.0 False True 20203828.06390582 44457218.00090321 25401754.43171296 1.0 2.200435375923938 1.2572743319417394 24.268125333702383 -10.427205688084866 5.134400934154958 0.9991650021368298 1.7288548539328668 0.4432844405722083 0.38504388383794763 0.0036841858229364134 0.0004110080577390444 0.37320745358829027 0.12427237913860145 3.739334460927724e-11 10.427205688084866 0.729689851796037 NGGQILIADLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGGQILIADLR 11 0 P55735;P55735-2;P55735-4;P55735-3;A8MXL6;E7ERC8 P55735 SEC13 Protein SEC13 homolog 0 17571700.0 4953000.0 4930400.0 7688300.0 False True 6493430.964920229 4194803.538548677 6892788.4673811905 1.0 0.6460072589068034 1.0615017707308245 22.630549532627374 -6.681064784159926 1.898256944000684 0.7762340661986143 1.0599267192776844 0.328898400652899 0.14999660232714812 0.4361843922221708 3.039756984186425 0.06338573601678134 0.16693857759760278 2.0841799606133844e-07 6.681064784159926 0.2836926530790701 NGGQILIADLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGGQILIADLR 11 0 P55735;P55735-2;P55735-4;P55735-3;A8MXL6;E7ERC8 P55735 SEC13 Protein SEC13 homolog 0 11777500.0 3632800.0 2114200.0 6030500.0 False True 3517478.752494187 2958411.0854073516 4450931.138877911 1.0 0.8410601153765578 1.26537541576387 21.746110278140964 -6.805285299432627 1.4345735762701577 0.9128843792514756 1.2720024627079918 0.847067390204217 0.06844951712459768 0.21330865458004056 0.8660894209919232 0.03753000717562457 0.08700213875254538 1.5657221682423418e-07 6.805285299432627 0.3591180834565162 NGGQILIADLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGGQILIADLR 11 0 P55735;P55735-2;P55735-4;P55735-3;A8MXL6;E7ERC8 P55735 SEC13 Protein SEC13 homolog 0 18018600.0 4953000.0 6058200.0 7007400.0 False True 6784257.94979214 5790528.692211635 5352396.441933123 1.0 0.8535242520354122 0.7889435339198907 22.693759594150265 -13.999999999999073 0.11113262695042442 1.7054119899419729 0.6723812065154458 0.9997373099842687 0.0014311156533574866 12.006047903716786 0.10134305967464403 1.8963831443553831 0.10350379753412331 1.0000000000021351e-14 13.999999999999073 -1.033030783426527 NGGVKPNIIPSYSELIYYFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGGVKPNIIPSYSELIYYFR 20 1 Q8IYS1 Q8IYS1 PM20D2 Peptidase M20 domain-containing protein 2 0 5993300.0 2188200.0 1169300.0 2635800.0 False True 2118736.7887601242 1636207.587818946 1945404.9076949516 1.0 0.7722561842032524 0.9181909324533862 21.0147729417739 -10.70189961973124 5.464099549203674 1.0036379330680532 0.8452235583283195 0.5999667112768411 0.059577611492391463 0.002696801581155206 0.00014712706929558613 0.058919572739899014 0.01922859142640397 1.9865540246950593e-11 10.70189961973124 -0.15841437473973363 NGGVKPNIIPSYSELIYYFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGGVKPNIIPSYSELIYYFR 20 1 Q8IYS1 Q8IYS1 PM20D2 Peptidase M20 domain-containing protein 2 0 4529100.0 2188200.0 1022600.0 1318300.0 False True 1819585.2536964645 1017091.0508297931 1593950.4348694924 1.0 0.5589686159324414 0.8759965665974717 20.795178217208175 -10.198986900122565 8.546272192258938 1.0000000403059568 0.7174825912649568 0.5142917385640582 0.12942611888826053 9.941927794533279e-08 9.39549236315445e-09 0.12531631942813007 0.04177210025154121 6.324309274709744e-11 10.198986900122565 -0.28251744904099996 NGHVGISFVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGHVGISFVPK 11 0 P21333-2;P21333;Q60FE5 P21333-2 FLNA Filamin-A 0 26018400.0 6726300.0 6426100.0 12866000.0 False True 8818244.437581867 5467350.9287416125 11534749.739386652 1.0 0.6200044654512736 1.3080551147150672 23.072060037659043 -6.756757293866788 1.624723534189565 0.7784047307813714 1.3101755664140131 0.677696168696919 0.1597597506273865 0.2883355487753093 1.4993380927504105 0.07761414292831598 0.1871176339071791 1.7508248664165236e-07 6.756757293866788 0.5317708356326417 NGHVGISFVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGHVGISFVPK 11 0 P21333-2;P21333;Q60FE5 P21333-2 FLNA Filamin-A 0 12261100.0 3892300.0 1200700.0 7168100.0 False True 3768741.067037301 1680145.771567782 5290559.5716094505 1.0 0.4458108799946252 1.4038002286446514 21.845651246753146 -6.749863682018554 1.6504041117165156 0.6740745527919667 1.4056771217268633 0.6483485270025076 0.23287227009412304 0.3002899767634601 1.6092655660121693 0.11146632958319004 0.27064303135924217 1.7788376706621088e-07 6.749863682018554 0.7316025689348966 NGHVGISFVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGHVGISFVPK 11 0 P21333-2;P21333;Q60FE5 P21333-2 FLNA Filamin-A 0 14208700.0 6726300.0 3327700.0 4154700.0 False True 9213194.88142276 3180671.210767666 3173445.4287324217 1.0 0.3452299936888436 0.3444457074419724 23.135270099181934 NGHVYK(ub)YDGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGHVYKYDGFR 11 1 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 1 6314900.0 1779800.0 2725700.0 1809400.0 True False 1479982.5585088034 2711016.113090911 2187737.174279647 1.0 1.8317892312342308 1.4782182139254134 20.49714874321818 -10.38909722219204 5.63777690393544 0.999764435307566 1.6550037225798246 0.8206555455138689 0.14434476337390265 0.00042753611407491716 4.632721146120832e-05 0.13981015740647326 0.046587072054946624 4.082279892176789e-11 10.38909722219204 0.6552392872722587 NGIDILVGTPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGIDILVGTPGR 12 0 Q9NR30-2;Q9NR30;A0A087WVC1;Q9BQ39 Q9NR30-2;A0A087WVC1 DDX21;DDX50 Nucleolar RNA helicase 2;ATP-dependent RNA helicase DDX50 0 15815600.0 4236100.0 5238800.0 6340700.0 False True 5553568.12245075 4457191.460682454 5684625.188289217 1.0 0.8025815768179551 1.0235987140067047 22.40498355853988 -6.671186906705217 1.9332529617178933 0.8741158169141698 1.0227080459763778 0.2842571953808076 0.08383647898281284 0.45841056490377685 3.304225134271541 0.03489826446726902 0.09309238453467199 2.132127115117933e-07 6.671186906705217 0.14859222906220793 NGIDILVGTPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGIDILVGTPGR 12 0 Q9NR30-2;Q9NR30;A0A087WVC1;Q9BQ39 Q9NR30-2;A0A087WVC1 DDX21;DDX50 Nucleolar RNA helicase 2;ATP-dependent RNA helicase DDX50 0 11727600.0 4176200.0 2658900.0 4892500.0 False True 4043628.8169363076 3720612.635980326 3611007.4781461195 1.0 0.9201172522059734 0.8930116095280062 21.947219141109446 -13.999999999999998 0.15089944054480164 1.3868111117608286 0.8634962177839746 0.9995632494335515 0.0009490858730733055 11.961225362889758 0.12238589582922173 1.356281275577912 0.026626921731798068 1.0000000000000041e-14 13.999999999999998 -0.523314893976854 NGIDILVGTPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGIDILVGTPGR 12 0 Q9NR30-2;Q9NR30;A0A087WVC1;Q9BQ39 Q9NR30-2;A0A087WVC1 DDX21;DDX50 Nucleolar RNA helicase 2;ATP-dependent RNA helicase DDX50 0 11898400.0 4236100.0 4126900.0 3535400.0 False True 5802300.646298096 3944559.912166679 2700411.3338485523 1.0 0.6798268743077511 0.4654035525669343 22.46819362006277 -8.243731672195343 0.13737433753802927 1.4179203942071785 1.3662013624482056e-10 0.9999485811229337 0.0015751532481938927 0.08566837009432639 0.028245867911294912 0.1309661958547793 0.13457136798289906 5.705166557581479e-09 8.243731672195343 -1.4179203940705585 down NGIDILVGTPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGIDILVGTPGR 12 0 Q9NR30-2;Q9NR30;A0A087WVC1;Q9BQ39 Q9NR30-2;A0A087WVC1 DDX21;DDX50 Nucleolar RNA helicase 2;ATP-dependent RNA helicase DDX50 0 8720700.0 4176200.0 2737700.0 1806800.0 False True 3472695.337029144 2722951.466709099 2184593.5263006887 1.0 0.7841031828143485 0.6290772193594116 21.727624416543723 -7.064683718855144 0.09489964884866926 1.4231892701087976 3.000843958406346e-10 0.9999997883790142 6.973398326804605e-05 0.0733395186600153 0.0029223797835252504 0.016087382401198308 0.027261002366274253 8.616210115307776e-08 7.064683718855144 -1.4231892698087132 NGIHDLDNISFPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGIHDLDNISFPK 13 0 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 0 7629630.0 2317500.0 977430.0 4334700.0 False True 2243932.231035363 1367722.896230115 3199312.0317874257 1.0 0.6095205894872503 1.425761432336682 21.097597675116884 -6.7766089778503344 1.5489530212903715 0.7779261135466146 1.4315668691958379 0.7552428550748508 0.16490946521417219 0.2558842121208628 1.2123531114312653 0.0838728212509055 0.1984836540196376 1.672595877958038e-07 6.7766089778503344 0.6536407556492233 NGIHDLDNISFPK(ub)QGS ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGIHDLDNISFPKQGS 16 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 66595000.0 15799000.0 24732000.0 26064000.0 True False 20712641.997733656 21042082.004580945 23367147.303542204 1.0 1.0159052624422966 1.1281587016325103 24.3040082522424 -6.93250424062485 0.7259371407674082 0.9984415439935321 1.1527460940345562 0.9970080276413091 0.0031198300923600286 0.09135805172766988 0.07146049578729913 0.0028859049539340887 0.010020789652148174 1.1681423235972422e-07 6.93250424062485 0.15430455004102406 NGIHDLDNISFPK(ub)QGS ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGIHDLDNISFPKQGS 16 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 129093000.0 26037000.0 30415000.0 72641000.0 True False 25210469.686933246 42559868.11212964 53614142.91671179 1.0 1.6881822766748653 2.126661802913587 24.587519660975904 -8.63347327960056 0.13314476335250264 3.377331129594538e-20 3.068770013228302 0.9999246565940554 0.004025008144179751 0.22306782275016557 0.03599039320741029 0.42194236769282084 0.3419305154570786 2.32555556358816e-09 8.63347327960056 3.068770013228302 NGIHDLDNISFPK(ub)QGS ddPTM_RPMI8226_Bortezomib_8h_R1 1 NGIHDLDNISFPKQGS 16 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 551074000.0 40064000.0 144880000.0 366130000.0 True False 60780017.07073347 119025032.04739332 293764245.0195205 1.0 1.9582921786428016 4.833237290434599 25.857093744268504 -6.951450097079068 0.5426902929086974 0.958406322379772 5.966501757038722 0.9993102244257861 0.04277850782948546 0.08290862963732577 0.033592553303411495 0.046879574040681125 0.23819083111707468 1.1182783137788636e-07 6.951450097079068 5.008095434658951 NGIHDLDNISFPK(ub)QGS ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGIHDLDNISFPKQGS 16 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 62920000.0 15799000.0 23607000.0 23514000.0 True False 21640317.251921285 22563964.68209038 17960477.486031257 1.0 1.0426817878599766 0.8299544446113274 24.367218313765292 -6.854515491839248 1.2130606411665736 1.0228979386493446 0.8206779940523986 0.9466265926960706 0.021228526044891775 0.15255984559340727 0.4297332575055844 0.01367590706526574 0.031752998037681196 1.3979270485888455e-07 6.854515491839248 -0.20221994459694603 NGIHDLDNISFPK(ub)QGS ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGIHDLDNISFPKQGS 16 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 104884000.0 26037000.0 49819000.0 29028000.0 True False 21650919.134674538 49550615.15870277 35097620.58969247 1.0 2.288614855123915 1.6210683884308024 24.36792493641018 -10.297712676803707 8.767621343196305 0.9999993354602655 1.9548416217773588 0.7317569678167973 0.27252470383265537 3.5403393163736424e-06 2.8343111538968827e-07 0.2638710945990266 0.08795696994783195 5.0383382801082895e-11 10.297712676803707 0.9548422863170932 NGIHDLDNISFPK(ub)QGS ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NGIHDLDNISFPKQGS 16 1 P49721;A0A087WVV1 P49721 PSMB2 Proteasome subunit beta type-2 1 464094000.0 40064000.0 120290000.0 303740000.0 True False 51863637.77950718 113595755.7565917 248462436.63558486 1.0 2.190277439456371 4.790686640453122 25.628220066360953 -6.958281019296551 0.45901816069511925 0.9234549895697036 6.1621642462218675 0.9997010371936115 0.027368008367885218 0.08032097627840931 0.02344404896367262 0.03525795023150445 0.21484338660311716 1.100826766129596e-07 6.958281019296551 5.238709256652164 NGK(ub)EVATDVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NGKEVATDVR 10 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0;E9PNG3 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 3317870.0 1592400.0 695770.0 1029700.0 True False 2061393.1908967437 657049.7878690156 842305.1656142152 1.0 0.3187406414121252 0.40860965745588645 20.97518828063232 -10.72288377562446 6.912327447646056 1.007729667278842 0.3636751494340058 0.9852607742066272 0.03668887216553501 0.004357466419033084 0.00017469127420303483 0.03541870795300899 0.011841282574020829 1.8928501088180927e-11 10.72288377562446 -0.6440545178448362 NGK(ub)TEDLGCMYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGKTEDLGCMYK 12 1 Q13618;Q13618-3;Q13618-2 Q13618 CUL3 Cullin-3 1 20037900.0 6567700.0 8133600.0 5336600.0 True False 8610318.301697271 6920098.584524482 4784419.824281898 1.0 0.8036983468033218 0.5556612028313507 23.037635140720056 -6.967950882713805 0.30316276300272915 1.0414326431892404 0.31011972759849205 0.9999616971678154 0.0011251939312893415 0.07697336576523883 0.011397479543470436 0.004051831878006416 0.022171946802578158 1.0765869652112551e-07 6.967950882713805 -0.7313129155907484 NGK(ub)TEDLGCMYK ddPTM_RPMI8226_Bortezomib_8h_R1 2 NGKTEDLGCMYK 12 1 Q13618;Q13618-3;Q13618-2 Q13618 CUL3 Cullin-3 1 81374600.0 26741300.0 32002400.0 22630900.0 True False 40568507.15089862 26291321.684107576 18157892.69552417 1.0 0.6480722001012849 0.4475859224492553 25.273856879114078 -10.082140621365735 0.11536704074154816 1.7832108480462896 1.0778649155722207e-12 0.9998827711087194 0.0024721690579734704 1.7078702871827591 0.05498651587393728 0.6387750981586071 0.24758340793121383 8.276741255131505e-11 10.082140621365735 -1.7832108480452118 NGK(ub)TEDLGCMYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGKTEDLGCMYK 12 1 Q13618;Q13618-3;Q13618-2 Q13618 CUL3 Cullin-3 1 20926200.0 6567700.0 7224900.0 7133600.0 True False 8995956.175418904 6905680.028450668 5448790.601103707 1.0 0.7676426934270941 0.6056933242952331 23.100845202242947 -7.577931532254616 0.09660829801863352 1.4670355723974107 6.159236398976002e-08 0.9999969717780662 0.00028155078266602876 0.137001106824289 0.009462953108762011 0.0587069938155417 0.08005210682044309 2.6428253733268486e-08 7.577931532254616 -1.4670355108050466 NGK(ub)TEDLGCMYK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NGKTEDLGCMYK 12 1 Q13618;Q13618-3;Q13618-2 Q13618 CUL3 Cullin-3 1 18267240.0 7495300.0 5299700.0 5472240.0 True False 6232674.04809026 5271149.46419192 6616460.0832209885 1.0 0.8457284022107721 1.0615764649602242 22.571419835016993 -6.714836630571977 1.778088891169237 0.9056292946235959 1.0611426082921072 0.48800216609326075 0.06496230274670871 0.3654250767655184 2.254984839336884 0.02904317624202824 0.07335038698179745 1.9282501305057933e-07 6.714836630571977 0.1555133136685113 NGK(ub)TEDLGCMYK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NGKTEDLGCMYK 12 1 Q13618;Q13618-3;Q13618-2 Q13618 CUL3 Cullin-3 1 63848300.0 26741300.0 23915400.0 13191600.0 True False 34617139.99982861 22584486.96667383 10790864.157246262 1.0 0.6524076502791868 0.3117202679741795 25.044983201206527 -7.390393196510729 0.28082343726116155 1.0963671321011952 1.5668322979583739e-12 0.999850827691001 0.0034319435215416864 0.1159737267667921 0.023242765246590393 0.018321257325965058 0.05616807477021369 4.070116154767358e-08 7.390393196510729 -1.0963671320996284 down NGLLHGHFTLPFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGLLHGHFTLPFLK 14 0 O95163 O95163 IKBKAP Elongator complex protein 1 0 14539300.0 3596100.0 6085600.0 4857600.0 False True 4714521.924681941 5177652.201483012 4354982.149389446 1.0 1.0982348336055974 0.9237378081942527 22.168680051388986 -6.753948710585328 1.6351624034526993 1.057486989065345 0.9232821024341568 0.6658294772581506 0.04128964308711227 0.2931987671386918 1.5435245405041471 0.01993734236934075 0.048204841322020825 1.7621841449723398e-07 6.753948710585328 -0.13420488663118835 NGLLHGHFTLPFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGLLHGHFTLPFLK 14 0 O95163 O95163 IKBKAP Elongator complex protein 1 0 16977300.0 3596100.0 3796100.0 9585100.0 False True 4925675.350948422 3628375.7499759975 7321296.7913310435 1.0 0.7366250293530543 1.4863539047333585 22.231890112911877 -6.811777738934288 1.4070244761090134 0.8567617059935373 1.5000132397601946 0.8644237875235674 0.11434846169364438 0.20438643168719156 0.7971390418172283 0.06389630772392284 0.14769142501176497 1.5424896586552103e-07 6.811777738934288 0.6432515337666573 NGLQNCATHTQPFWGSLTNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGLQNCATHTQPFWGSLTNR 20 0 F6UB75;A0A140T9U6;A0A140T9T8;A0A140T9R2;A0A140T9R0;A0A140T9I2;A0A140T9C9;A0A140T926;A0A0G2JIJ2;A0A0G2JI43;P28068 F6UB75 HLA-DMB HLA class II histocompatibility antigen, DM beta chain 0 14013500.0 3477800.0 4052700.0 6483000.0 False True 3367399.142651477 5670964.244551308 4784907.814168888 1.0 1.6840784250143905 1.4209505946483287 21.683203305338235 -10.067288266531447 4.647470066839986 0.99997727179321 1.5525145096420032 0.8546269096780035 0.10742148698853828 74532459.25185941 1.11923982024969 20387.802552119294 0.036773232229897736 8.564691680703066e-11 10.067288266531447 0.5525372378487932 NGLQNCATHTQPFWGSLTNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGLQNCATHTQPFWGSLTNR 20 0 F6UB75;A0A140T9U6;A0A140T9T8;A0A140T9R2;A0A140T9R0;A0A140T9I2;A0A140T9C9;A0A140T926;A0A0G2JIJ2;A0A0G2JI43;P28068 F6UB75 HLA-DMB HLA class II histocompatibility antigen, DM beta chain 0 5912900.0 1077700.0 1475800.0 3359400.0 False True 1476154.813747423 1410594.276182025 2565978.909014775 1.0 0.9555869499900465 1.7382857713282003 20.49341260326533 -6.893455354853746 1.0017026204014963 0.9613617353332121 1.8103492930689618 0.9830198324950342 0.046775052925561736 0.11638496928857911 0.20582224651321218 0.0354078341821955 0.0894456204243087 1.278040584424852e-07 6.893455354853746 0.8489875577357496 NGLQNCATHTQPFWGSLTNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGLQNCATHTQPFWGSLTNR 20 0 F6UB75;A0A140T9U6;A0A140T9T8;A0A140T9R2;A0A140T9R0;A0A140T9I2;A0A140T9C9;A0A140T926;A0A0G2JIJ2;A0A0G2JI43;P28068 F6UB75 HLA-DMB HLA class II histocompatibility antigen, DM beta chain 0 11440900.0 3477800.0 4219300.0 3743800.0 False True 2891944.792663178 4196569.79343452 4526611.270624598 1.0 1.451123757300332 1.565248161759016 21.46360858077251 -11.882377200281198 0.23072311566214418 8.882118639759079e-10 1.626590604986295 0.9993575518713421 0.006185818967046399 4.895450804359109 0.13672051898260373 2.4173110574521304 0.058747302185039874 1.3110607012914845e-12 11.882377200281198 1.626590604098083 NGLSLK(ub)EEHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGLSLKEEHR 10 1 Q13422-4;Q13422-3;Q13422-7;Q13422;Q13422-2;A0A0A0MRA0;A0A0A0MST1;A0A087WU46;Q13422-6;Q13422-5;R9R4D9 Q13422-4 IKZF1 DNA-binding protein Ikaros 1 7534410.0 909310.0 2000800.0 4624300.0 True False 880444.4517811284 2799729.8740341607 3413057.103973653 1.0 3.1799051812642367 3.87651611304845 19.74787246013114 -9.54718101389503 0.332113237733538 9.701463737236302e-20 4.07644855643447 0.998556135206056 0.04655811285180016 0.9093407111543688 0.1359436144128976 1.2300421456722217 0.21682607034637758 2.836736430555198e-10 9.54718101389503 4.07644855643447 NGLSLK(ub)EEHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGLSLKEEHR 10 1 Q13422-4;Q13422-3;Q13422-7;Q13422;Q13422-2;A0A0A0MRA0;A0A0A0MST1;A0A087WU46;Q13422-6;Q13422-5;R9R4D9 Q13422-4 IKZF1 DNA-binding protein Ikaros 1 5980410.0 909310.0 2271700.0 2799400.0 True False 756131.5542631978 2259461.9012028533 3384741.5970368283 1.0 2.988186233551059 4.476392471591857 19.528277735565418 -7.856076439169011 0.2249751160550178 5.447990803109791e-20 6.154977501855651 0.999786569875502 0.0208052569057973 0.12331252294873817 0.036117790262902134 0.31038943608931396 0.4880064046563708 1.3929116182109284e-08 7.856076439169011 6.154977501855651 NGMNMSFSFLNYAQSSQCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NGMNMSFSFLNYAQSSQCR 19 0 Q9Y316;Q9Y316-3;Q9Y316-2 Q9Y316 MEMO1 Protein MEMO1 0 20230900.0 5783600.0 6062500.0 8384800.0 False True 8774144.037796872 4980599.508471299 6727540.604811602 1.0 0.5676450588246661 0.7667460866645224 23.064826959395653 -10.062849266296105 4.798968889001169 1.0000096073490234 0.6671955727401268 0.7883765547973689 0.08128265426431572 20890398.69504604 43804601.607527405 1443.386234347268 0.02782522197377838 8.652681815055431e-11 10.062849266296105 -0.3328140346088967 NGMVLK(ub)PHFHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGMVLKPHFHK 11 1 P26373;J3QSB4;P26373-2;H3BTH3 P26373 RPL13 60S ribosomal protein L13 1 4129270.0 651070.0 1259000.0 2219200.0 True False 853559.0749708487 1071162.1075435625 1989578.472069555 1.0 1.2549361127466725 2.3309206479205957 19.70313148031797 -6.943642837941271 0.6247534448359461 0.9882527025927004 2.655074607127888 0.9986031810442323 0.02155662894044719 0.08614332515115444 0.04733167180159783 0.02161597927596144 0.09122686962107152 1.1385632508036204e-07 6.943642837941271 1.6668219045351875 up NGMVLK(ub)PHFHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGMVLKPHFHK 11 1 P26373;J3QSB4;P26373-2;H3BTH3 P26373 RPL13 60S ribosomal protein L13 1 3777230.0 651070.0 980760.0 2145400.0 True False 891788.1735051825 937426.7802603879 1638700.705899953 1.0 1.0511765104215527 1.8375447831507152 19.766341541840863 -6.920133648236041 0.8237356951406102 0.9827329435732035 1.964744147890646 0.9942179783874853 0.029148243346259296 0.09809309993887792 0.10520738331373475 0.025132003646023953 0.07537866179215434 1.2018945109675717e-07 6.920133648236041 0.9820112043174425 NGMVLK(ub)PHFHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGMVLKPHFHK 11 1 P26373;J3QSB4;P26373-2;H3BTH3 P26373 RPL13 60S ribosomal protein L13 1 8236200.0 1751300.0 4260200.0 2224700.0 True False 1456283.5457447306 4237249.457016513 2689874.4841494043 1.0 2.9096321725242187 1.8470815604620638 20.473859852205017 -10.55001616197905 6.078922282237232 0.9974652012340057 2.3783568664930317 0.6917091243057842 0.4337844709057062 0.014910628156243869 0.0011037378192703697 0.42025055438490544 0.1400033359717662 2.8182780489778254e-11 10.55001616197905 1.380891665259026 NGMVLKPHFHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGMVLKPHFHK 11 1 P26373;J3QSB4;P26373-2;H3BTH3 P26373 RPL13 60S ribosomal protein L13 0 39399900.0 5885900.0 12414000.0 21100000.0 False True 7716471.89913668 10561879.589392992 18916774.405491896 1.0 1.368744644890712 2.4514797245109268 22.87950994310603 -6.95193276107991 0.5372109676248165 0.9837602781827386 2.8862260986568256 0.999344332678142 0.015773243454010287 0.08271889865290787 0.032821967869469934 0.01741599875704702 0.08962690566776943 1.1170361776598414e-07 6.95193276107991 1.902465820474087 up NGMVLKPHFHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGMVLKPHFHK 11 1 P26373;J3QSB4;P26373-2;H3BTH3 P26373 RPL13 60S ribosomal protein L13 0 41058380.0 6215200.0 5227500.0 29615680.0 False True 6017901.878028473 7314868.011052375 21858444.956644382 1.0 1.215517992700938 3.632236849266382 22.520829153025037 -6.9243955456668465 0.7914454551108058 0.9546407491475253 4.064279859918087 0.9953173682880065 0.08165711746762869 0.09565388719159597 0.09271495511318893 0.07204687065539052 0.22578298384677215 1.1901575454696489e-07 6.9243955456668465 3.1096391107705617 up NGMVLKPHFHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGMVLKPHFHK 11 1 P26373;J3QSB4;P26373-2;H3BTH3 P26373 RPL13 60S ribosomal protein L13 0 27241280.0 5885900.0 9904200.0 11451180.0 False True 8062076.290466698 9466599.69519041 8746647.128455037 1.0 1.1742136087678234 1.0849124733287174 22.94272000462892 -10.33045425084124 5.726444768915861 0.9999810170311765 1.1295630410482709 0.7373012795054688 0.03645703587949928 8.836838046564253e-06 1.033210268811053e-06 0.035304542883181654 0.011766457734448569 4.672461689128302e-11 10.33045425084124 0.1295820240170944 NGMVLKPHFHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NGMVLKPHFHK 11 1 P26373;J3QSB4;P26373-2;H3BTH3 P26373 RPL13 60S ribosomal protein L13 0 4423090.0 3883300.0 539790.0 0.0 False True 5027008.401286944 509750.21198645455 0.0 1.0 0.10140229959750127 0.0 22.261268669434614 -10.930156698809546 0.4164446142718487 1.935162186743185 1.3171897947962779e-18 0.9994048519814271 0.010963759053804145 2.979036488902379 0.22654843080008832 2.7280433556833383 0.02544779159839763 1.1744737138681493e-11 10.930156698809546 -1.935162186743185 NGNYCVLQMDQSYKPDENEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGNYCVLQMDQSYKPDENEVR 21 1 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 9717400.0 1181200.0 3993000.0 4543200.0 False True 1548564.6387570729 3397259.9645920955 4073113.2454516958 1.0 2.19381217907626 2.630250713151313 20.562500173239552 -9.930467680165135 0.25240399031722127 4.765982044983265e-25 2.8722079692372278 0.999084608484411 0.020848177910371708 1.3732642170665477 0.11239433201508651 1.1798606063769395 0.19269325403660423 1.1736330200366537e-10 9.930467680165135 2.8722079692372278 NGNYCVLQMDQSYKPDENEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGNYCVLQMDQSYKPDENEVR 21 1 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 8046300.0 1181200.0 3517900.0 3347200.0 False True 1617921.5607297563 3362467.5458603753 2556660.2977478905 1.0 2.0782636361825535 1.5802127617328496 20.625710234762444 -10.441999235713437 5.462850207342931 0.9992579987050525 1.8292381989577045 0.7870597415580054 0.20332841805813917 0.0018389674947074813 0.00018784027898898615 0.19703072008795194 0.06562396474582045 3.6141049866184294e-11 10.441999235713437 0.829980200252652 NGPK(ub)VLEFNCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGPKVLEFNCR 11 1 P22102;P22102-2;F8WD69 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 51174500.0 10580100.0 21061900.0 19532500.0 True False 13870613.55783414 17919546.61864316 17511464.26897014 1.0 1.2919072789337556 1.2624866373758674 23.725528269988892 -10.172732589194036 4.996017187194899 0.9999795945470557 1.2771969581552673 0.9916221048551233 0.012010926621938211 2.7301058699665285e-06 4.5206408429893617e-07 0.011630385172104697 0.003876509898047755 6.718424032389989e-11 10.172732589194036 0.2772173636082117 NGPK(ub)VLEFNCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NGPKVLEFNCR 11 1 P22102;P22102-2;F8WD69 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 90068300.0 25418900.0 22158800.0 42490600.0 True False 38562329.67050881 18204389.012505367 34092314.28570841 1.0 0.4720770028172722 0.8840833678101425 25.200688876115603 -9.876608201209027 6.553652412519677 1.0000000139774625 0.6780801853136922 0.44873316515487494 0.16820089416863576 3.439967167283049e-08 5.924758700045387e-09 0.1628598227634452 0.05428660516101712 1.3285925070423848e-10 9.876608201209027 -0.32191982866377034 NGPK(ub)VLEFNCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGPKVLEFNCR 11 1 P22102;P22102-2;F8WD69 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 38516900.0 10580100.0 12623400.0 15313400.0 True False 14491848.886451807 12065656.447998466 11696690.30937276 1.0 0.8325822703877661 0.8071220174195858 23.788738331511784 -13.999999999522801 0.26516278980232466 2.2592833812234487 0.7982665715605783 0.999573033093596 0.00176785442112425 14.651546719548472 0.1629737319748535 9.917205065227922 0.010836185244438657 1.0000000010987906e-14 13.999999999522801 -1.4610168096628704 NGPK(ub)VLEFNCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGPKVLEFNCR 11 1 P22102;P22102-2;F8WD69 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 13073300.0 4165910.0 580790.0 8326600.0 True False 3464138.7461048495 577661.1689922108 10067653.562151497 1.0 0.16675462830169407 2.9062500956325086 21.724065283542615 -6.825095795389873 1.3496745471699274 0.5530463750156629 2.972860000946763 0.8957120583058958 0.3702898491593281 0.18693646958002955 0.667678473985514 0.21551418221329188 0.4961836869461321 1.495905657263628e-07 6.825095795389873 2.4198136259311003 NGPK(ub)VLEFNCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NGPKVLEFNCR 11 1 P22102;P22102-2;F8WD69 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 61870500.0 25418900.0 13778000.0 22673600.0 True False 32905267.131427545 13011242.188164609 18547237.45078227 1.0 0.39541518189766284 0.5636555806309792 24.971815198208052 -10.738997168896907 10.470330553204544 1.00096295345224 0.4795353812645615 0.9273271182781495 0.06868385516983506 0.0015459350272623749 3.853674763980475e-05 0.06659000035726216 0.02216761893550778 1.823907592071432e-11 10.738997168896907 -0.5214275721876784 NGQIDK(ub)EAVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NGQIDKEAVQK 11 1 Q01813;Q01813-2;Q5VSR5 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 1 4998750.0 1176300.0 964450.0 2858000.0 True False 1784533.0990491163 792336.3622177565 2293115.0472941 1.0 0.44400205445331936 1.2849944047078645 20.76711522968627 -6.728396714708998 1.7289546413689834 0.664821189708221 1.28436543027231 0.5519560685089113 0.23375761888209196 0.33920865867234523 1.9857335298321603 0.10717266012600307 0.26643808561926285 1.8689741097556073e-07 6.728396714708998 0.619544240564089 NGQIDK(ub)EAVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NGQIDKEAVQK 11 1 Q01813;Q01813-2;Q5VSR5 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 1 4402700.0 1176300.0 1054600.0 2171800.0 True False 1522743.5383395143 995910.582932095 1776554.6845498225 1.0 0.6540238443684958 1.166680166305009 20.538241551778718 -6.724912236463766 1.7417024851069665 0.7906246605789429 1.1661078082012126 0.535579427150958 0.14550714501328668 0.34585076893856614 2.052887980266727 0.0662695979744736 0.16540412253518874 1.8840297814324348e-07 6.724912236463766 0.37548314762226975 NGQTREHALLAYTLGVKQLIVGVNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGQTREHALLAYTLGVKQLIVGVNK 25 2 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 18108900.0 5077400.0 4088000.0 8943500.0 False True 4916220.716228245 5720359.718638379 6600929.050751121 1.0 1.163568531363066 1.3426836246309533 22.229118257016008 -6.969959905363613 0.25914195693826714 0.9491835630926551 1.5623767273645195 0.999982066735216 0.0005926192066960463 0.07631572314933409 0.009076684059154138 0.0037598949633235036 0.01692162733489952 1.0716182338722979e-07 6.969959905363613 0.6131931642718644 NGQTREHALLAYTLGVKQLIVGVNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGQTREHALLAYTLGVKQLIVGVNK 25 2 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 15342600.0 5077400.0 3573900.0 6691300.0 False True 4222083.066958423 3554646.6913363943 8090419.892924393 1.0 0.8419177536213546 1.9162152341907164 22.009523532450284 -6.869490726261717 1.1367289063415238 0.9108561013166705 1.9785409000304082 0.9641752500298171 0.08963769249741324 0.1373471272427669 0.33200685581786077 0.06121495276069325 0.1448084014211349 1.3505456665206232e-07 6.869490726261717 1.0676847987137377 NGQVIGIGAGQQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGQVIGIGAGQQSR 14 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 15091400.0 2205200.0 6680900.0 6205300.0 False True 2891038.555187175 5684135.761944235 5563235.081440702 1.0 1.9661224343568902 1.9243033170412078 21.463156418196707 -10.250144353536202 5.377247256447181 0.9999122250862711 1.9452128756991365 0.9985340651676453 0.01707258315314189 1.7966810706505587e-05 2.5054709220728285e-06 0.01653197288669031 0.005510152519027283 5.6215444169808316e-11 10.250144353536202 0.9453006506128654 NGQVIGIGAGQQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGQVIGIGAGQQSR 14 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 9885500.0 2205200.0 3050900.0 4629400.0 False True 3020522.033289242 2916101.1500228574 3536031.0654858025 1.0 0.9654295243949358 1.170668853434977 21.5263664797196 -6.863578654363156 1.167607799780137 0.9810355992903462 1.1813045888650056 0.9578388482678863 0.018422248479801825 0.1431557610857834 0.3688536998022654 0.012287333814796233 0.028806261794398377 1.3690564183688683e-07 6.863578654363156 0.20026898957465933 NGQVIGIGAGQQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGQVIGIGAGQQSR 14 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 5551400.0 2807500.0 1649100.0 1094800.0 False True 2334560.6433382775 1640215.9709792777 1323717.6182167325 1.0 0.7025801517127738 0.567009309436442 21.15471963432623 -13.99999999999151 0.1057341360870166 2.447286961157154 0.30230905886833426 0.9997647476178813 0.0027736645622678897 12.039449974055909 0.09794781794371828 3.751539573323574 0.2354288371239039 1.0000000000195472e-14 13.99999999999151 -2.1449779022888196 NGSEADIDEGLYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGSEADIDEGLYSR 14 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 24382200.0 2592200.0 11407000.0 10383000.0 False True 3398399.3029005066 9705120.064137738 9308666.760768836 1.0 2.8557915651214074 2.739132730172103 21.696423944644884 -10.162840088099058 4.4177522713706985 0.9996422460033703 2.797462147687384 0.996850749720477 0.04762577015764397 7862535.850775815 19.9833204469326 28792.143659674097 0.017185469478099888 6.873214725880211e-11 10.162840088099058 1.7978199016840137 NGSEADIDEGLYSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGSEADIDEGLYSR 14 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 12869400.0 4552500.0 1347300.0 6969600.0 False True 4407983.379412512 1885283.9160766825 5144052.676481802 1.0 0.42769760087615155 1.166985497383475 22.071687353468192 -6.700040941019545 1.8309676872009797 0.6446343771623511 1.1647710180615674 0.4176877149585987 0.24157419986498832 0.39542266292485845 2.577306960441527 0.10526229130379007 0.2706686191018681 1.995074230094249e-07 6.700040941019545 0.5201366408992163 NGSEADIDEGLYSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGSEADIDEGLYSR 14 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 19583900.0 2592200.0 9350100.0 7641600.0 False True 3550606.391571003 8936981.66535408 5836811.463692125 1.0 2.517029678809264 1.6438914427542521 21.759634006167776 -10.109167946347418 6.514902491863562 0.9999983020501223 2.08046056078176 0.6712357840660799 0.3564571922080994 8.790583387389028e-06 1.2030718156570696e-06 0.34513873719101673 0.11504606408815099 7.777357341052872e-11 10.109167946347418 1.0804622587316377 NGSEADIDEGLYSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGSEADIDEGLYSR 14 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 7192700.0 4552500.0 1431400.0 1208800.0 False True 3785605.459945686 1423688.764089345 1461554.4911402895 1.0 0.37607954108080016 0.3860820961414344 21.85209262890247 -10.578696775509439 6.406143568788023 1.0012379554050843 0.38108081861111737 0.9998041466151538 0.004083526003774592 7.232048021396939e-05 4.756183381093176e-06 0.003960440036493573 0.0013179523505353256 2.6381727156382164e-11 10.578696775509439 -0.6201571367939669 NGTSSNK(ub)NKEDEDIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGTSSNKNKEDEDIAK 16 2 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 39012800.0 9712800.0 14289000.0 15011000.0 True False 12733574.858889008 12157136.898085758 13457805.715679567 1.0 0.9547308617421877 1.0568756900411977 23.602134166496178 -6.786233573671085 1.511386854774358 0.974574664925727 1.0578515851985302 0.7888797407456848 0.019201636811312848 0.2410118939974799 1.0876471668188772 0.010002430287686073 0.023483601775358763 1.6359364401267424e-07 6.786233573671085 0.0832769202728032 NGTSSNK(ub)NKEDEDIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGTSSNKNKEDEDIAK 16 2 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 42691000.0 12507000.0 15302000.0 14882000.0 True False 12109972.130985672 21412168.39887583 10983957.749569857 1.0 1.7681434909407194 0.9070175910203219 23.529692209133536 -6.67146999827693 1.9322940366493073 1.4896844287399384 0.9104847581903018 0.28553544412426657 0.3261808255861504 0.4577399976243765 3.296400013130461 0.1358339842535043 0.3622026959114503 2.1307377570622597e-07 6.67146999827693 -0.5791996705496366 NGTSSNK(ub)NKEDEDIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NGTSSNKNKEDEDIAK 16 2 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 47665000.0 13579000.0 18678000.0 15408000.0 True False 20600335.75787465 15344764.968119923 12362602.046433702 1.0 0.7448793625732173 0.6001165316787613 24.296164515808048 -13.999999999999996 0.06535312980388583 2.537908342427521 0.020465840464443132 0.9999392980869115 0.0012879489107498368 12.408580375640504 0.06740105182018755 2.9997639732982497 0.5380596605554384 1.0000000000000082e-14 13.999999999999996 -2.5174425019630777 NGTSSNK(ub)NKEDEDIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGTSSNKNKEDEDIAK 16 2 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 26624800.0 9712800.0 0.0 16912000.0 True False 13303884.638550607 0.0 12917733.913573232 1.0 0.0 0.9709745885905814 23.66534422801907 -11.913726964730285 13.795347532621902 0.860060210191068 0.5369385648657748 0.0 0.4799708967008495 0.0 0.0 0.0 0.13675514404441103 1.219756202719678e-12 11.913726964730285 -0.3231216453252932 NGTSSNK(ub)NKEDEDIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGTSSNKNKEDEDIAK 16 2 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 34657400.0 12507000.0 12717000.0 9433400.0 True False 10400124.654045178 12648490.996873125 11405880.324886484 1.0 1.216186480221988 1.0967061169262151 23.310097484567812 -10.181840911666885 4.188488897711835 0.9999418475088497 1.156446298587727 0.6956786460227944 0.048777654106469566 34228589.467600875 2.1078268636929725 19327.555254105013 0.016697888403288712 6.578987910372073e-11 10.181840911666885 0.15650445107887734 NGTSSNK(ub)NKEDEDIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NGTSSNKNKEDEDIAK 16 2 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 32665600.0 13579000.0 13523000.0 5563600.0 True False 17578283.18210683 12770433.162327634 4551081.88735676 1.0 0.7264892157003608 0.2589036619906867 24.067290837900497 -7.08160911304728 0.419399698290286 1.0223944880433062 4.734880185259907e-11 0.9997946293736074 0.004385062932680078 0.074885050963941 0.020719764384581115 0.006640437468667988 0.03722896586134125 8.286876889010493e-08 7.08160911304728 -1.0223944879959574 down NGVDLLMK(ub)YIYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGVDLLMKYIYK 12 1 O15511;B1ALC0;O15511-2;Q9BPX5 O15511;Q9BPX5 ARPC5;ARPC5L Actin-related protein 2/3 complex subunit 5;Actin-related protein 2/3 complex subunit 5-like protein 1 21895200.0 7929600.0 3356700.0 10608900.0 True False 7677879.188443589 4697047.814959251 7830110.829822056 1.0 0.611763704491345 1.0198273035615877 22.87227642885723 -11.012338672600798 12.38148901430644 1.2618613275620443 0.8157955040264664 0.21364863475489204 0.16659126672095778 0.05237365222827805 5.219256325566851e-05 0.007015410714306954 0.05376710013615562 9.719889493207193e-12 11.012338672600798 -0.4460658235355779 NGVDLLMK(ub)YIYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NGVDLLMKYIYK 12 1 O15511;B1ALC0;O15511-2;Q9BPX5 O15511;Q9BPX5 ARPC5;ARPC5L Actin-related protein 2/3 complex subunit 5;Actin-related protein 2/3 complex subunit 5-like protein 1 52842300.0 3825900.0 15885400.0 33131000.0 True False 5804170.010755769 13050526.256803317 26582643.32816686 1.0 2.248474154378533 4.57992155276401 22.46865834753001 -6.96136365986129 0.4157697381620888 0.892130397826528 6.023606085974647 0.9998174770134974 0.02004387310345673 0.07921755329618188 0.01935771607525707 0.030087680382463518 0.1943105648710408 1.0930407168193065e-07 6.96136365986129 5.131475688148119 NGVDLLMK(ub)YIYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGVDLLMKYIYK 12 1 O15511;B1ALC0;O15511-2;Q9BPX5 O15511;Q9BPX5 ARPC5;ARPC5L Actin-related protein 2/3 complex subunit 5;Actin-related protein 2/3 complex subunit 5-like protein 1 21059400.0 7929600.0 5429200.0 7700600.0 True False 6593813.740842459 5399951.821988171 9310759.856448464 1.0 0.8189421227567532 1.412044716819507 22.652681704291506 -6.824776350354896 1.3509326758139175 0.902847354618534 1.426382641835669 0.895028751877038 0.08040804141783467 0.18736191706238292 0.6705232235286374 0.046753758147064284 0.10765569492931179 1.49700637450205e-07 6.824776350354896 0.523535287217135 NGVDLLMK(ub)YIYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NGVDLLMKYIYK 12 1 O15511;B1ALC0;O15511-2;Q9BPX5 O15511;Q9BPX5 ARPC5;ARPC5L Actin-related protein 2/3 complex subunit 5;Actin-related protein 2/3 complex subunit 5-like protein 1 52592800.0 3825900.0 15308900.0 33458000.0 True False 4952702.96976379 14456946.257395342 27368987.30807075 1.0 2.9190012697419725 5.526070809244605 22.23978466962246 -6.966850867735159 0.3247222932585859 0.662181003963394 7.867569220255814 0.9999463709714868 0.013583511983953637 0.07733838272927293 0.012674674778680855 0.038790012595330374 0.22838819857296885 1.0793172850734551e-07 6.966850867735159 7.20538821629242 NGVLPDCLTDGSDVVSDLEHEEMK(ub)ILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NGVLPDCLTDGSDVVSDLEHEEMKILR 27 1 B5MCA1;Q96G28;Q96G28-2;B5MC35;B5MD16 B5MCA1 CFAP36 Cilia- and flagella-associated protein 36 1 29208900.0 6438800.0 13081000.0 9689100.0 True False 9768130.33933302 10746593.347680524 7774045.138116605 1.0 1.1001689140456652 0.795858047349461 23.21965102012603 -6.818003835007067 1.380390824243162 1.0541020284666498 0.7894893738798594 0.879756161366384 0.04390992167830646 0.19608490685280028 0.7346919850285533 0.02499982080369086 0.05765624423710764 1.5205341027030976e-07 6.818003835007067 -0.2646126545867904 NGVQAMVEFDSVQSAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGVQAMVEFDSVQSAQR 17 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;B4DVF8;M0R1W6;M0QYL7 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 14556400.0 4507900.0 2501300.0 7547200.0 False True 4364799.181999703 3500082.134107186 5570361.908853223 1.0 0.8018884691285264 1.2762011896962462 22.057483848425665 -6.793264519284898 1.4833756777741713 0.88974401905968 1.2817014655988497 0.8116983355798875 0.08440523378367244 0.2305176564157418 1.0019631552686803 0.04478065524145359 0.10459367015054777 1.609664924789773e-07 6.793264519284898 0.39195744653916964 NGVQAMVEFDSVQSAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGVQAMVEFDSVQSAQR 17 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;B4DVF8;M0R1W6;M0QYL7 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 9751700.0 4507900.0 2695300.0 2548500.0 False True 3748518.5838306737 2680779.883924835 3081379.5670673577 1.0 0.7151571544792239 0.8220259545621472 21.83788912385994 -10.650786869619537 6.878366745721116 1.0009169870906864 0.7685915545206856 0.8621005183360998 0.043629004937777785 0.0006158172358281583 3.1264805911999405e-05 0.0424020688290621 0.014081200794634548 2.234668619274933e-11 10.650786869619537 -0.23232543257000082 NGYELSPTAAANFTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGYELSPTAAANFTR 15 0 P49721 P49721 PSMB2 Proteasome subunit beta type-2 0 19336100.0 3338700.0 7330400.0 8667000.0 False True 4377068.032016787 6236732.893675405 7770221.979734515 1.0 1.4248654231681555 1.7752116080668483 22.061533377036678 -6.97333471816543 0.15954223459519104 0.6431841139158788 2.5661848371628637 0.999998087919481 0.00043825600040458315 0.07523472002814659 0.004922607555917522 0.01628693838706276 0.04211299930840816 1.063323181019783e-07 6.97333471816543 1.923000723246985 NGYELSPTAAANFTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGYELSPTAAANFTR 15 0 P49721 P49721 PSMB2 Proteasome subunit beta type-2 0 15425500.0 4058400.0 2162200.0 9204900.0 False True 3929568.3134558434 3025577.7357240394 6793860.548919203 1.0 0.769951682825742 1.7289076068878337 21.905939401847768 -6.843384434736656 1.2666710483051935 0.8776250599051564 1.762603616018005 0.930103972380181 0.10806962410651189 0.16488420384662875 0.5124338924793383 0.06686170865075915 0.15419753072652345 1.4342193093954534e-07 6.843384434736656 0.8849785561128486 NGYELSPTAAANFTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGYELSPTAAANFTR 15 0 P49721 P49721 PSMB2 Proteasome subunit beta type-2 0 17215200.0 3338700.0 7140200.0 6736300.0 False True 4573107.6149749635 6824722.354516121 5145324.678453364 1.0 1.4923598850304955 1.1251265248175302 22.12474343855957 -10.611453960399155 11.06370665291116 0.9999844821062325 1.308743204924012 0.4851810462894933 0.14992239150824313 5.738919482071452e-05 2.0153359577377863e-06 0.1451690029554069 0.0483872437945845 2.4465046165002868e-11 10.611453960399155 0.3087587228177795 NGYGFINR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGYGFINR 8 0 P67809;C9J5V9;Q9Y2T7;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX2;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 2;Y-box-binding protein 3 0 27546800.0 2028800.0 12942000.0 12576000.0 False True 2659776.446927146 11011104.047520872 11274756.157510232 1.0 4.139860724100351 4.238986389452399 21.342873562245003 -10.28450468568918 0.7098301742265252 9.107517876882318e-17 4.221513278838369 0.9998910720544316 0.01569758427333148 1.6039930372454505 0.3591251132872942 3.216549011522642 0.015290428478484108 5.193920696528685e-11 10.28450468568918 4.221513278838369 NGYGFINR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGYGFINR 8 0 P67809;C9J5V9;Q9Y2T7;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX2;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 2;Y-box-binding protein 3 0 17091300.0 4537800.0 2002500.0 10551000.0 False True 4393750.022866138 2802108.6928995447 7787376.576784815 1.0 0.6377487745813242 1.7723758830742355 22.06702136101748 -6.820831348240853 1.3684449302208677 0.8049157825047573 1.79755548602647 0.8862481716741516 0.15959294495087054 0.19240440297079991 0.7077782658955182 0.09164440210399859 0.21116233324896755 1.5106666850587357e-07 6.820831348240853 0.9926397035217127 NGYGFINR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGYGFINR 8 0 P67809;C9J5V9;Q9Y2T7;P16989;P16989-3;P16989-2 P67809;P16989;P16989-2 YBX1;YBX2;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 2;Y-box-binding protein 3 0 26944800.0 2028800.0 12622000.0 12294000.0 False True 2778902.186258487 12064318.304627644 9390410.402877796 1.0 4.3413972482676835 3.3791798967638518 21.406083623767895 -10.499247734117464 11.744346810985014 0.9999962381492776 3.860288572515768 0.9217638282433693 0.3928235888061053 3.869405597633435e-05 1.6494822011102703e-06 0.38035029917148616 0.12678326812028967 3.167759965780102e-11 10.499247734117464 2.8602923343664903 NGYGFVEFDDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGYGFVEFDDLR 12 0 Q08170;A0A0D9SEM4 Q08170 SRSF4 Serine/arginine-rich splicing factor 4 0 6106100.0 1343800.0 2326900.0 2435400.0 False True 1761734.8133777098 1979735.590185158 2183408.170006397 1.0 1.1237421064464765 1.2393512084944434 20.74856534703438 -6.9719446509342635 0.20653045802753256 0.9367272691777332 1.4295809051412192 0.9999938360414028 0.00024257745776588038 0.0756766444915164 0.006723112944490248 0.0035592675277597483 0.012077956116767442 1.0667320632312269e-07 6.9719446509342635 0.49285363596348597 NGYGFVEFDDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NGYGFVEFDDLR 12 0 Q08170;A0A0D9SEM4 Q08170 SRSF4 Serine/arginine-rich splicing factor 4 0 7712900.0 2445600.0 1400800.0 3866500.0 False True 2367965.76665376 1960146.7450754975 2853747.657486352 1.0 0.8277766396282987 1.205147345317861 21.1752167936036 -6.782662326734459 1.5258835638321047 0.9028182709343072 1.2083690214051106 0.7765612347564883 0.07291587354652923 0.2464666443625043 1.1336764828446466 0.0376338703636097 0.08859020332300743 1.6494443714198143e-07 6.782662326734459 0.3055507504708034 NGYGFVEFDDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGYGFVEFDDLR 12 0 Q08170;A0A0D9SEM4 Q08170 SRSF4 Serine/arginine-rich splicing factor 4 0 6744900.0 1343800.0 2519800.0 2881300.0 False True 1840639.1748295317 2408466.904135699 2200796.2822361966 1.0 1.3084948625842194 1.1956695871367728 20.81177540855727 -10.094966122403447 4.209460652107997 0.9999616631202894 1.2520822248327674 0.8693827199356737 0.046060725980738654 6517363.641610434 5209897.454114441 2043.8666334716772 0.01576781156528045 8.035888045282936e-11 10.094966122403447 0.252120561712478 NGYGFVEFEDSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NGYGFVEFEDSR 12 0 A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247;Q13247-2 A0A590UJK4 SRSF6 Serine/arginine-rich splicing factor 6 0 10151600.0 1892400.0 3266100.0 4993100.0 False True 2480954.726027667 2778810.611158084 4476461.909197235 1.0 1.1200569611390383 1.8043303500199843 21.242463977617263 -6.936931961298207 0.6875159705056946 0.9917610483044363 1.973312006385373 0.9977337752542619 0.016865174195292588 0.08919457975287103 0.061195596535272075 0.01605780780261127 0.05973345927583111 1.1562933785899712e-07 6.936931961298207 0.9815509580809367 NGYGFVEFEDSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NGYGFVEFEDSR 12 0 A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247;Q13247-2 A0A590UJK4 SRSF6 Serine/arginine-rich splicing factor 6 0 8331700.0 1892400.0 3208300.0 3231000.0 False True 2592071.4201870863 3066546.697570663 2467904.3445337703 1.0 1.1830486898194073 0.9520973555410931 21.305674039140154 -6.695448489459593 1.8467849300788888 1.1141652049364839 0.9528322427416446 0.39619503542342793 0.07733274241147832 0.40504388201370745 2.6823445217471575 0.0334453462031194 0.08650927767005376 2.0162831025841236e-07 6.695448489459593 -0.16133296219483928 NGYGFVEFEDSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NGYGFVEFEDSR 12 0 A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247;Q13247-2 A0A590UJK4 SRSF6 Serine/arginine-rich splicing factor 6 0 5661200.0 2613300.0 1827500.0 1220400.0 False True 2173074.7388195638 1817654.8947696502 1475579.9975079482 1.0 0.8364438011722591 0.6790286459772195 21.051306363479863 -6.9715925659712985 0.2168197420966081 1.0755721767623023 0.4354717323262323 0.9999922773048553 0.00036412207039255835 0.07578941372345128 0.007152354321208041 0.00446837028307449 0.01606417789187902 1.0675972195210579e-07 6.9715925659712985 -0.6401004444360701 NHCPHLDSVGEITK(ub)EDLIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NHCPHLDSVGEITKEDLIQK 20 1 Q8TEY7-2;Q8TEY7;Q8TEY7-3;E9PP47;E9PLK7;E9PQP0 Q8TEY7-2 USP33 Ubiquitin carboxyl-terminal hydrolase 33;Ubiquitinyl hydrolase 1 1 10204800.0 2852700.0 2699900.0 4652200.0 True False 3739917.3255860987 2297085.444127769 4170834.9710535253 1.0 0.6142075463574006 1.1152211687994722 21.834574947649582 -6.701053194450219 1.827234379223743 0.760681304604314 1.1137535328226769 0.4224885932514483 0.16281727985743774 0.3933540193854373 2.554047117922853 0.07106898429044597 0.18252525847487774 1.9904295267966432e-07 6.701053194450219 0.3530722282183628 NHCPHLDSVGEITK(ub)EDLIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NHCPHLDSVGEITKEDLIQK 20 1 Q8TEY7-2;Q8TEY7;Q8TEY7-3;E9PP47;E9PLK7;E9PQP0 Q8TEY7-2 USP33 Ubiquitin carboxyl-terminal hydrolase 33;Ubiquitinyl hydrolase 1 1 9944600.0 3176700.0 3619200.0 3148700.0 True False 3075857.397337666 5064365.433878668 2323961.0110247717 1.0 1.6464890206750715 0.7555490098586156 21.552557188058646 -6.712052963547522 1.7876048581459536 1.3965989490564594 0.7574850646937404 0.47500393705103894 0.27233989725234237 0.3709496098681369 2.311881722554725 0.12117340518497564 0.3071059447774442 1.9406491950241673e-07 6.712052963547522 -0.639113884362719 NHCPHLDSVGEITK(ub)EDLIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NHCPHLDSVGEITKEDLIQK 20 1 Q8TEY7-2;Q8TEY7;Q8TEY7-3;E9PP47;E9PLK7;E9PQP0 Q8TEY7-2 USP33 Ubiquitin carboxyl-terminal hydrolase 33;Ubiquitinyl hydrolase 1 1 12558200.0 2852700.0 3090300.0 6615200.0 True False 3907420.2813188066 2953760.3277444844 5052826.004320575 1.0 0.7559361714597926 1.2931360438696342 21.897785009172473 -6.783164708658285 1.5232816483153873 0.8623711470062825 1.2978403552409792 0.7784913448423993 0.1033614946597251 0.24569968848982177 1.1262179097202123 0.05342995352553022 0.12575663446108867 1.6475374350585714e-07 6.783164708658285 0.4354692082346967 NHCPHLDSVGEITK(ub)EDLIQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NHCPHLDSVGEITKEDLIQK 20 1 Q8TEY7-2;Q8TEY7;Q8TEY7-3;E9PP47;E9PLK7;E9PQP0 Q8TEY7-2 USP33 Ubiquitin carboxyl-terminal hydrolase 33;Ubiquitinyl hydrolase 1 1 21011200.0 8639500.0 4785800.0 7585900.0 True False 11184003.06000529 4519466.02294369 6205344.037907035 1.0 0.4041009286831823 0.5548410532985047 23.414933324766945 -10.347505453399599 8.775769322782278 1.000000977919964 0.4794709909911852 0.9408250366250109 0.06153939817851506 1.1774497558845518e-06 8.756740998148187e-08 0.059585378365012175 0.01986175535675134 4.4925668335615984e-11 10.347505453399599 -0.5205299869287787 NHGFEVLYHSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NHGFEVLYHSVK 12 0 O14526;O14526-2;M0QZI3;A0A0C3SFZ9;M0QXD1;M0R1K4;M0QZI9;M0R3E5;M0R3E7;M0QYT8;M0QXY1;M0QY09;M0QXW2;M0R107;M0R2J7;M0QZF0;M0QYA9;M0QZS1 O14526 FCHO1 F-BAR domain only protein 1 0 6723000.0 1119800.0 2135700.0 3467500.0 False True 1468068.6441586274 1817061.8848933992 3108716.3626086772 1.0 1.2377226992234993 2.1175551803916703 20.48548799681859 -6.9466606591893685 0.5943750998442955 0.9899544369999684 2.4099294144126873 0.9989124941174583 0.015851810766791298 0.08485500769021453 0.04173001219338197 0.016360949680710793 0.0738065705926923 1.1306790382166865e-07 6.9466606591893685 1.4199749774127188 up NHIPVFSPALTDGSLGDMIFFHSYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NHIPVFSPALTDGSLGDMIFFHSYK 25 0 P49366;P49366-3;A0A087WZK0;P49366-2;Q5J8M5;M0R1T4;M0R0V2;M0R1T2 P49366 DHPS Deoxyhypusine synthase 0 8164700.0 3837000.0 2923400.0 1404300.0 False True 3190635.5079212687 2907651.0639505326 1697932.6372504188 1.0 0.9113078121057133 0.5321612678837888 21.60541237664106 -6.94335056636534 0.6276180026900064 1.004136488651925 0.4189818970789417 0.998570657325074 0.007670716258670063 0.08627077652401481 0.047894548362096306 0.007672175674626437 0.0321819266115129 1.1393297391848915e-07 6.94335056636534 -0.5851545915729834 NHLLQFALESPAK(ub)SPASSSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NHLLQFALESPAKSPASSSSK 21 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 9348300.0 1589000.0 2194000.0 5565300.0 True False 1538558.0647746236 3070075.641558853 4107580.9745787615 1.0 1.995423969915997 2.6697601271099654 20.55314746095251 -8.151451840878561 0.1601798723288428 6.984990973384795e-23 3.8666772295807226 0.9999140379933267 0.006359042477454592 0.0898292037733479 0.031712392661597456 0.3206968503006555 0.3551810684717733 7.055830821558569e-09 8.151451840878561 3.8666772295807226 NHLLQFALESPAK(ub)SPASSSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NHLLQFALESPAKSPASSSSK 21 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 6570600.0 1589000.0 3144200.0 1837400.0 True False 1321323.9046356261 3127261.570525166 2221591.8448222736 1.0 2.366763788616655 1.68133781355822 20.333552736386785 -10.023593588430739 5.93756920389597 0.9999983675463917 2.024050801087551 0.7485029506858792 0.27982398255753616 6.046946215226408e-06 9.947815245573365e-07 0.27093883793139584 0.09031280202617192 9.471230619187952e-11 10.023593588430739 1.0240524335411592 NHLLQFALESPAK(ub)SPASSSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NHLLQFALESPAKSPASSSSK 21 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 28687700.0 4875600.0 5451100.0 18361000.0 True False 6311560.31244421 5147741.49309799 15019486.39976946 1.0 0.8156052130165701 2.379678820490115 22.589565274493214 -6.87749975728732 1.0936887131116844 0.8890993306248368 2.4853261085197653 0.9716102890419098 0.11759440089127124 0.12986593072376248 0.28588812264926444 0.08300576739029554 0.1995080384481592 1.3258678587436123e-07 6.87749975728732 1.5962267778949286 up NHQENYFLEK(ub)QYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NHQENYFLEKQYK 13 1 Q14586 Q14586 ZNF267 Zinc finger protein 267 1 4172680.0 797880.0 1922100.0 1452700.0 True False 663472.5720772016 1911745.2657930206 1756452.8534741057 1.0 2.881423206098368 2.647363172791 19.33967730032451 -10.03719895357338 5.653076180698806 0.9999936349203582 2.764393189445305 0.9869734173208862 0.09555460846584096 7.665432732070199e-06 1.3057320366221546e-06 0.09252068617174353 0.03084011726981192 9.17911997751088e-11 10.03719895357338 1.7643995545249467 NHTLALTETGSVFAFGENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NHTLALTETGSVFAFGENK 19 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 10840300.0 3019600.0 1655600.0 6165100.0 False True 2923744.4508454707 2316689.713839945 4550275.3609644715 1.0 0.7923707946397363 1.5563177416715235 21.47938578772477 -6.834292099757795 1.308492885071639 0.8893386671319918 1.5787562433824436 0.914209106183054 0.09446848823410453 0.17557526778829335 0.5863621008846261 0.056656563481451275 0.1304030799784962 1.4645624675343932e-07 6.834292099757795 0.6894175762504517 NHTVSFHLNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NHTVSFHLNK 10 0 A0A2R8YH03;Q5VWN6-2;Q5VWN6 A0A2R8YH03 FAM208B Protein FAM208B 0 4275490.0 1083800.0 980790.0 2210900.0 False True 1420872.295534129 834459.9550894767 1982137.2764503327 1.0 0.5872870895661947 1.3950143743954238 20.438345463891626 -6.76779512076893 1.582938606621951 0.7626252598786414 1.3991838197799693 0.7221208603132176 0.17384085529223162 0.2699663892896785 1.3346701349228764 0.08658355239486468 0.2065207360881938 1.7068874264231429e-07 6.76779512076893 0.6365585599013279 NHTVSFHLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NHTVSFHLNK 10 0 A0A2R8YH03;Q5VWN6-2;Q5VWN6 A0A2R8YH03 FAM208B Protein FAM208B 0 3457910.0 1083800.0 853310.0 1520800.0 False True 1484510.1485937247 815607.9426811782 1161618.361859163 1.0 0.5494121703740477 0.782492705058004 20.501555525414517 -10.058135288660115 5.625647329132267 1.0000016796143394 0.6659524377159238 0.7325268417627628 0.09515472982548834 2.004594607347854e-06 3.3556039971247053e-07 0.09213363497567287 0.030711056993862857 8.747112482862824e-11 10.058135288660115 -0.33404924189841556 NHTVSFHLNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NHTVSFHLNK 10 0 A0A2R8YH03;Q5VWN6-2;Q5VWN6 A0A2R8YH03 FAM208B Protein FAM208B 0 2593020.0 978290.0 759690.0 855040.0 False True 813491.4805953345 755597.399183341 1033824.9107417212 1.0 0.928832590392188 1.270849093570274 19.633767711585726 -6.8524060192990595 1.2233580972382303 0.961928275393219 1.2851745824635168 0.9437420471066422 0.0349487966154676 0.15483027075691705 0.44468792566189363 0.022339243314127278 0.05178227074741034 1.404733633026446e-07 6.8524060192990595 0.3232463070702978 NIAFFSTNCVEGTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIAFFSTNCVEGTAR 15 0 P05023-4;P05023;P05023-3;P05023-2 P05023-4 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 0 2992200.0 0.0 1468000.0 1524200.0 False True 0.0 1248980.1222191807 1366490.4051588017 0.0 NIAFFSTNCVEGTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIAFFSTNCVEGTAR 15 0 P05023-4;P05023;P05023-3;P05023-2 P05023-4 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 0 3184100.0 0.0 1411000.0 1773100.0 False True 0.0 1348657.3544469678 1354330.2981407691 0.0 NIAIQSQFTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIAIQSQFTR 10 0 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 0 58265400.0 6579400.0 32350000.0 19336000.0 False True 9981430.818569882 26576889.74829633 15514231.124730144 1.0 2.6626332668510355 1.5543093376820087 23.250815207220988 -10.509767151837025 5.164706005252945 0.9967430138008637 2.108471302266536 0.5714936936599362 0.45247134936349626 0.0169930695697431 0.0016129770841927175 0.43872685690150304 0.14603450006006105 3.0919527470284684e-11 10.509767151837025 1.1117282884656723 NIAIQSQFTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIAIQSQFTR 10 0 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 0 26213300.0 6033100.0 4513200.0 15667000.0 False True 8263700.108397134 4313791.900843416 11966777.271993369 1.0 0.5220169953239191 1.4481136918114157 22.978356468737857 -6.766439155184881 1.5882529051875813 0.724595096132539 1.4526157444430674 0.7166958902801535 0.20127156790857736 0.27222543519882914 1.3546855626863554 0.0999248352883686 0.23863178493968298 1.7122250432520586e-07 6.766439155184881 0.7280206483105284 NICEGGEEMDNK(ub)FGVEQPEGDEDLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NICEGGEEMDNKFGVEQPEGDEDLTK 26 1 P24928;P24928-2 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 14449100.0 6408300.0 4327500.0 3713300.0 True False 8401343.358065486 3681853.8684628825 3329083.3364887694 1.0 0.43824585087671925 0.3962560741304272 23.002188599723347 -13.999999999999998 0.3679654790294596 8.725450132860008 0.39176325001538964 0.9997873980316451 0.004013307233109816 22.584153219098226 0.19671560642969782 137.5013619910765 0.011810632017922014 1.0000000000000041e-14 13.999999999999998 -8.333686882844619 NICEGGEEMDNK(ub)FGVEQPEGDEDLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NICEGGEEMDNKFGVEQPEGDEDLTK 26 1 P24928;P24928-2 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 18909300.0 6408300.0 4526800.0 7974200.0 True False 8777621.687795887 4326791.007874222 6090858.193804135 1.0 0.49293432341588017 0.6939075766129977 23.06539866124624 -10.179983504516425 5.377770313438638 1.0000158228470784 0.59342095001435 0.8451287893146356 0.08204698704699812 1.556563985295936e-05 2.373554697841716e-06 0.07944474139808276 0.026480551203247913 6.607185431109197e-11 10.179983504516425 -0.4065948728327283 NICFTVWDVGGQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NICFTVWDVGGQDK 14 0 P84085;C9J1Z8 P84085 ARF5 ADP-ribosylation factor 5 0 3742600.0 934660.0 1892600.0 915340.0 False True 1225348.3112603168 1610231.45729702 820629.3973612774 1.0 1.3141010131566888 0.6697111260693127 20.22476046998153 -6.774166465558509 1.5585911325376938 1.1791983052716524 0.6655086201483892 0.7462227148548491 0.13253944207719803 0.2597385692250285 1.2457592936813717 0.06700816051404063 0.1588998952183392 1.6820292138223968e-07 6.774166465558509 -0.5136896851232632 NICFTVWDVGGQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NICFTVWDVGGQDK 14 0 P84085;C9J1Z8 P84085 ARF5 ADP-ribosylation factor 5 0 5410860.0 934660.0 1751000.0 2725200.0 False True 1280229.0602367716 1673635.030217321 2081563.8872557813 1.0 1.3072934228721467 1.6259308212163275 20.28797053150442 -6.97066994606942 0.2416509830118854 0.8879034369500558 2.054555784457972 0.9999871458585327 0.0009161939083957842 0.07608588248078146 0.008248503967974793 0.007528444416406819 0.030973317232062928 1.0698676454238234e-07 6.97066994606942 1.1666523475079162 NICFTVWDVGGQDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NICFTVWDVGGQDR 14 0 P18085;C9JPM4;C9JAK5 P18085 ARF4 ADP-ribosylation factor 4 0 6212300.0 1642500.0 2838200.0 1731600.0 False True 2153333.4059926253 2414751.623216949 1552430.6426800832 1.0 1.121401644769365 0.7209429985898802 21.03814028220265 -6.825394580074564 1.3484750432021677 1.0651017782116408 0.7111542699231033 0.8963227913666422 0.05398362238947082 0.18656446128145437 0.6650900055402661 0.03144719212676086 0.0723941896941922 1.4948768622707526e-07 6.825394580074564 -0.3539475082885375 NICFTVWDVGGQDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NICFTVWDVGGQDR 14 0 P18085;C9JPM4;C9JAK5 P18085 ARF4 ADP-ribosylation factor 4 0 27270500.0 6569600.0 12452000.0 8248900.0 False True 9966563.502093898 10229843.312079936 6618501.2993787 1.0 1.0264163078809185 0.6640705492909571 23.248664714557123 -6.889366645229415 1.0261508160427206 1.0197660025532467 0.6332927436741604 0.9804887556999841 0.023038975806498357 0.1196573885144231 0.22487563624678084 0.017121568913707877 0.04258703565875824 1.2901296452049724e-07 6.889366645229415 -0.38647325887908623 NICFTVWDVGGQDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NICFTVWDVGGQDR 14 0 P18085;C9JPM4;C9JAK5 P18085 ARF4 ADP-ribosylation factor 4 0 9940800.0 1642500.0 2789900.0 5508400.0 False True 2249776.6368935164 2666632.9930344415 4207429.369059059 1.0 1.1852878856082882 1.8701542633444102 21.101350343725542 -6.9466918855738236 0.5940636282676988 0.9921740589035148 2.0979703670800833 0.9989153544471597 0.012325407239343831 0.08484214813695573 0.04167584227882962 0.01272530295731473 0.057445713445422715 1.1305977437252019e-07 6.9466918855738236 1.1057963081765685 NICFTVWDVGGQDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NICFTVWDVGGQDR 14 0 P18085;C9JPM4;C9JAK5 P18085 ARF4 ADP-ribosylation factor 4 0 18762700.0 6569600.0 8128400.0 4064700.0 False True 8504476.706176363 7676047.394562151 3324966.307343983 1.0 0.9025890316081921 0.39096659585524307 23.019791036649572 -6.938714015924849 0.6714242139343701 1.005890505597135 0.2580673782221878 0.9979905118709678 0.01197417998208572 0.08835835072962142 0.05731904465125852 0.011545350239976052 0.04428968105734434 1.1515584436343344e-07 6.938714015924849 -0.7478231273749472 down NICQQVNIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NICQQVNIK 9 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 9540600.0 1751500.0 3645600.0 4143500.0 False True 2296233.4615501272 3101690.690437502 3714770.367258563 1.0 1.3507732303245994 1.6177668470830568 21.130837899795022 -6.974152204334633 0.12379012287276232 0.5463802920094856 2.4290384090585744 0.999999368349049 0.00020097202235899603 0.0749769213143696 0.003697416457665488 0.018005985029899037 0.037683108706011874 1.0613235369235529e-07 6.974152204334633 1.8826581170490888 NICQQVNIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NICQQVNIK 9 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 6842200.0 1751500.0 1986600.0 3104100.0 False True 2399076.8825077596 1898825.4431923064 2370975.510946231 1.0 0.7914816974133236 0.9882865898269362 21.194047961317914 -10.54821278323858 7.882623509364249 1.0000302399678198 0.8898841436347951 0.29448966354057127 0.08034526088278181 4.271036067395456e-05 2.4479842539575966e-06 0.07781530499840673 0.02593132144547533 2.8300050907924463e-11 10.54821278323858 -0.11014609633302475 NIDDGTSDRPYSHALVAGIDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIDDGTSDRPYSHALVAGIDR 21 1 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 0 99332500.0 6358300.0 21532000.0 71442200.0 False True 8335792.873864794 18319509.531078648 64050046.46597302 1.0 2.1976925060741124 7.6837377601822485 22.99088799958448 -6.941777212327217 0.6428165498047741 0.9398117717859599 9.243850351388616 0.9983875476927674 0.11684487614350811 0.08696511415790356 0.05098697590772212 0.11533423606047806 0.4685998881693179 1.1434647675779076e-07 6.941777212327217 8.304038579602656 NIDDGTSDRPYSHALVAGIDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIDDGTSDRPYSHALVAGIDR 21 1 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 0 20500300.0 6358300.0 0.0 14142000.0 False True 8709135.336596688 0.0 10801950.863632469 1.0 0.0 1.240301183315128 23.05409806110737 -6.692159435831544 1.858919220900947 0.3743212120075445 1.2361055147469224 0.38043565768873033 0.42274839334540826 0.4120637219315801 2.7624243972994287 0.18182419807427258 0.47216732267429473 2.031611040004868e-07 6.692159435831544 0.8617843027393779 NIDLATPLHHTWTYQALVHDVLDFHLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIDLATPLHHTWTYQALVHDVLDFHLNR 28 0 Q8WVM8;Q8WVM8-2;Q8WVM8-3 Q8WVM8 SCFD1 Sec1 family domain-containing protein 1 0 59042400.0 21495400.0 19550000.0 17997000.0 False True 32610093.324237294 16061149.755152812 14439885.06163468 1.0 0.49252081542543275 0.4428041624432367 24.95881523403823 -13.999999999999998 0.3284605620353191 6.4733033620881795 0.4338398935419911 0.999711637384103 0.004275291999661244 18.694237669795935 0.18318732467428037 70.62750744829728 0.016024114775044077 1.0000000000000041e-14 13.999999999999998 -6.039463468546188 NIDLATPLHHTWTYQALVHDVLDFHLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIDLATPLHHTWTYQALVHDVLDFHLNR 28 0 Q8WVM8;Q8WVM8-2;Q8WVM8-3 Q8WVM8 SCFD1 Sec1 family domain-containing protein 1 0 44574500.0 21495400.0 14339000.0 8740100.0 False True 27826219.03768015 13541022.04500598 7149491.480999133 1.0 0.48662816988070706 0.25693363052011614 24.72994155613068 -10.619088821858325 0.1688018230829868 1.8616967147417742 9.955167388596891e-24 0.9995725180362295 0.0064226142647204896 2.4731610282277 0.08962051201383146 1.0474602844312426 0.17688505540874744 2.40387111028086e-11 10.619088821858325 -1.8616967147417742 NIDNPALADIYTEHAHQVVVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIDNPALADIYTEHAHQVVVAK 22 0 O75083;D6RD66 O75083 WDR1 WD repeat-containing protein 1 0 18191900.0 2084100.0 9884400.0 6223400.0 False True 2732275.282453111 8409686.049089422 5579462.267068159 1.0 3.077905840270596 2.0420571466205875 21.381671414819856 -9.933780998098854 5.782687544039275 0.9999989353315828 2.5599814934467724 0.751492428323321 0.4228834583660258 5.8085246571367885e-06 1.0709355769506656e-06 0.40945542238378935 0.13648504930257427 1.1647132118774006e-10 9.933780998098854 1.5599825581151896 NIDNPALADIYTEHAHQVVVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIDNPALADIYTEHAHQVVVAK 22 0 O75083;D6RD66 O75083 WDR1 WD repeat-containing protein 1 0 17088500.0 4296700.0 3516700.0 9275100.0 False True 4160303.6103946655 4920936.6493482245 6845673.06296435 1.0 1.1828311369038285 1.6454743941908936 21.988257386447167 -6.955201697393942 0.4984788352282777 0.9906112727186422 1.8575969134291836 0.9995487895868311 0.005770133641404698 0.08146181334257682 0.027820169061840542 0.006786393033289798 0.03816207107512662 1.1086598058921678e-07 6.955201697393942 0.8669856407105414 NIDNPALADIYTEHAHQVVVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIDNPALADIYTEHAHQVVVAK 22 0 O75083;D6RD66 O75083 WDR1 WD repeat-containing protein 1 0 15163200.0 2084100.0 6482300.0 6596800.0 False True 2854648.0906847985 6195890.551900479 5038771.7053606855 1.0 2.1704568672120117 1.7651113360708288 21.444881476342747 -10.08132902650825 4.96726067377639 0.9999740911404197 1.9677841016447881 0.8837283434327545 0.16548162015397652 4.8482097601313466e-05 8.966252493379195e-06 0.16023125587215825 0.05340896324401236 8.292223010989673e-11 10.08132902650825 0.9678100105043684 NIEDVIAQGIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIEDVIAQGIGK 12 0 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 0 40859900.0 5283900.0 35576000.0 0.0 False True 6927244.06936038 30268199.474161834 0.0 1.0 4.369443197192937 0.0 22.723850074895868 -6.700817721874486 1.8281279740595804 3.090766058703801 0.012995310177399655 0.42117268836627575 1.422100549769173 0.39394551079438717 2.5602405565844633 0.6204763194588463 1.5939892788642704 1.9915090216354117e-07 6.700817721874486 -3.077770748526401 NIEDVIAQGIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIEDVIAQGIGK 12 0 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 0 91704000.0 33578000.0 17364000.0 40762000.0 False True 32512084.769667976 24297535.752063744 30085209.36621197 1.0 0.7473385949932081 0.9253546667139553 24.95447273301829 -9.99032504218928 5.400172919783067 1.0000005774383438 0.8363466310991384 0.5298234484139958 0.07267475695628078 5.052121213393368e-07 9.456135759752657e-08 0.07036727934830779 0.023455676948272955 1.0225274081684712e-10 9.99032504218928 -0.16365394633920538 NIEDVIAQGIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIEDVIAQGIGK 12 0 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 0 98903900.0 5283900.0 42310000.0 51310000.0 False True 7237500.622028397 40440604.299540214 39191634.76262079 1.0 5.587647782226545 5.4150786037012955 22.78706013641876 -10.192041755344556 4.319584343836616 0.998544636314584 5.501363193047811 0.9988989141851621 0.07045107274729809 6185867.348963729 242.8068302216958 89609.76784544112 0.02411727599734533 6.426259289264726e-11 10.192041755344556 4.502818556733227 NIEDVIAQGIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIEDVIAQGIGK 12 0 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 0 41452100.0 33578000.0 4787900.0 3086200.0 False True 27921594.75761809 4762106.632376258 3731510.151023459 1.0 0.17055281668956146 0.1336424435429269 24.734878008452565 -13.250848922122056 0.4516634839515902 9.999999999994142 0.13376079634321625 0.999888984782096 0.004214429964813149 17.755862245908485 0.22835138705114238 155.65387875884633 0.008303940849969622 5.61243181557614e-14 13.250848922122056 -9.866239203650926 NIEDVIAQGIGK(ub)LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIEDVIAQGIGKLASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK 45 1 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 1 198841000.0 87714000.0 70080000.0 41047000.0 True False 133068550.75235401 57573676.4624609 32934042.45846079 1.0 0.432661783245899 0.24749681477896593 26.987594405970512 -13.999999999999998 0.1565609907046191 3.7747203026799436 0.05838245320468448 0.9995458393345478 0.006822564464477706 11.988517418013634 0.12491483251924201 10.105218126689635 0.17164754752092404 1.0000000000000041e-14 13.999999999999998 -3.7163378494752592 NIEDVIAQGIGK(ub)LASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIEDVIAQGIGKLASVPAGGAVAVSAAPGSAAPAAGSAPAAAEEK 45 1 P05387;H0YDD8 P05387 RPLP2 60S acidic ribosomal protein P2 1 201056000.0 87714000.0 76676000.0 36666000.0 True False 113547502.10142994 72408913.19637898 29993164.224930406 1.0 0.6376971034703819 0.2641464027816134 26.75872072806296 -7.4584188964271885 0.3202386376006567 1.0725358850317581 5.197507501781183e-12 0.9996524014180108 0.005601076063051373 0.1202172122169227 0.031867865715792504 0.01954857976105909 0.0622051557429526 3.480014901209681e-08 7.4584188964271885 -1.0725358850265607 down NIEK(ub)LLSHLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIEKLLSHLER 11 1 Q15306;Q15306-2;F2Z3D5 Q15306 IRF4 Interferon regulatory factor 4 1 8330600.0 2864000.0 2080500.0 3386100.0 True False 2773083.88767434 2911254.499664175 2499178.829177431 1.0 1.0498256156634742 0.9012272727434073 21.403059828868248 -6.816298047869702 1.3879270087948758 1.0269606054551108 0.898236818647729 0.8756188295017274 0.021778621865140433 0.19834535821521906 0.751761325117726 0.012334062974506559 0.02845835037389405 1.526518078959973e-07 6.816298047869702 -0.12872378680738183 NIELICQENEGENDPVLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIELICQENEGENDPVLQR 19 0 Q15691 Q15691 MAPRE1 Microtubule-associated protein RP/EB family member 1 0 9760460.0 693760.0 4560700.0 4506000.0 False True 909526.0783813971 3880261.337469359 4039762.344604097 1.0 4.266245278392365 4.441612440396765 19.794755478572107 -10.16036576026762 0.6350422112758828 3.5430650757962915e-12 4.417779847038874 0.999739440387352 0.025547353838190526 1.4462649412920616 0.3090364670870226 2.720407427798947 0.029137365075725966 6.912485602153403e-11 10.16036576026762 4.417779847035331 NIELICQENEGENDPVLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIELICQENEGENDPVLQR 19 0 Q15691 Q15691 MAPRE1 Microtubule-associated protein RP/EB family member 1 0 9827360.0 693760.0 3858100.0 5275500.0 False True 950261.8201590545 3687636.384969416 4029535.5523329885 1.0 3.8806530018770835 4.240447702779983 19.857965540094998 -9.976209226525048 0.49566190782182545 1.3068161208630723e-22 4.232772839306491 0.9991734532882565 0.041693286332243264 1.2649236748771706 0.22594664260952335 2.0033512561937363 0.07340588938539466 1.0563084974471789e-10 9.976209226525048 4.232772839306491 NIFAILQSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIFAILQSVK 10 0 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3 A0A3B3IRP5 CDC73 Parafibromin 0 10590800.0 1751000.0 5335800.0 3504000.0 False True 2295577.9567081206 4539719.438785499 3141439.692741398 1.0 1.9775932355159471 1.36847441123117 21.130425995426517 -10.226399427149964 5.788991712341571 0.999977632491942 1.6730338233735602 0.6194575684110637 0.24867171870365398 7.179860614245859e-05 9.594647003101067e-06 0.2407833356581096 0.08025845210099705 5.937458304737762e-11 10.226399427149964 0.6730561908816182 NIFAILQSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIFAILQSVK 10 0 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3 A0A3B3IRP5 CDC73 Parafibromin 0 11577400.0 4474200.0 3740600.0 3362600.0 False True 4332168.970053257 5234241.086971306 2481834.1841623187 1.0 1.2082264388009223 0.5728848993006402 22.046658083624024 -6.818405385935921 1.378649765366143 1.1124173796092964 0.55947006834647 0.8807059026045417 0.0913412435611683 0.19555721099146334 0.7307627367234878 0.05206873516961213 0.12007049222536167 1.5191288587390655e-07 6.818405385935921 -0.5529473112628265 NIFAILQSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIFAILQSVK 10 0 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3 A0A3B3IRP5 CDC73 Parafibromin 0 4373620.0 595520.0 3778100.0 0.0 False True 903447.3783437283 3103868.536569966 0.0 1.0 3.4355830909158485 0.0 19.78508104762031 -6.716372013014206 1.7726437850868297 2.487679260087861 0.006672972341849205 0.4948954903987117 1.0254149611358838 0.36259630656611136 2.2247328317473984 0.4596866367789198 1.158819268270402 1.9214451299810353e-07 6.716372013014206 -2.4810062877460117 NIFAILQSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIFAILQSVK 10 0 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3 A0A3B3IRP5 CDC73 Parafibromin 0 21139800.0 1751000.0 5967800.0 13421000.0 False True 2398392.0189957675 5704122.863124453 10251236.214171369 1.0 2.3783113093883754 4.274212110855702 21.19363605694941 -6.966656909345079 0.3283757674101044 0.7646004959412888 5.949837480244751 0.9999433375372312 0.010103693076816947 0.07740312319605913 0.012901258625414759 0.02782654825656965 0.16558294707135704 1.0797994219770827e-07 6.966656909345079 5.1852369843034625 NIFAILQSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIFAILQSVK 10 0 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3 A0A3B3IRP5 CDC73 Parafibromin 0 8842800.0 4474200.0 2042600.0 2326000.0 False True 3720495.5406675413 2031596.108375645 2812355.845791123 1.0 0.5460552461813005 0.7559089414434622 21.8270633590583 -10.072032374034483 4.832820227583283 1.000010350422152 0.6509820938094997 0.7866932828022537 0.08567241235438494 1.0553608405729673e-05 2.0264542107176217e-06 0.08295467214109772 0.027650652187521628 8.471642608002095e-11 10.072032374034483 -0.34902825661265235 NIFAILQSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIFAILQSVK 10 0 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3 A0A3B3IRP5 CDC73 Parafibromin 0 8100120.0 595520.0 3415200.0 4089400.0 False True 770912.3794541748 3225141.11779792 3345171.16078739 1.0 4.183537849115098 4.339236533152905 19.55620736971276 -10.194531131937127 0.6459773302504399 5.706737528382188e-13 4.317022625428343 0.9997765647867846 0.02300079037013906 1.4867329101608118 0.3163727470799048 2.805141534710393 0.0255596579271991 6.389529330464777e-11 10.194531131937127 4.3170226254277715 NIFAILQSVK(ub)AR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIFAILQSVKAR 12 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3 A0A3B3IRP5 CDC73 Parafibromin 1 4402100.0 655640.0 1525530.0 2220930.0 True False 859550.3892267908 1297926.8704693648 1991129.468264887 1.0 1.5100067276299136 2.3164778856723096 19.7132226914022 -6.96436566171183 0.3687841824241766 0.9371206054541958 2.917382186457661 0.9998994566922085 0.005434434029401315 0.07817696834441597 0.015623479852311552 0.010649948722375142 0.0685380728732879 1.0855112738496949e-07 6.96436566171183 1.980261581003465 NIFAILQSVK(ub)AR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIFAILQSVKAR 12 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3 A0A3B3IRP5 CDC73 Parafibromin 1 13004300.0 3419700.0 3862100.0 5722500.0 True False 3311143.495349143 5404256.6705854405 4223605.578679851 1.0 1.632142091750569 1.2755731017433583 21.658898103629824 -10.225520009721816 4.9549012604727185 0.9999441711834314 1.4538575965961034 0.6835627623126928 0.1455686807226828 0.00010612205625796023 1.6587684099098786e-05 0.140966678356025 0.046982089662662346 5.949493443795315e-11 10.225520009721816 0.453913425412672 NIFAILQSVK(ub)AR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIFAILQSVKAR 12 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3 A0A3B3IRP5 CDC73 Parafibromin 1 4033340.0 655640.0 2001400.0 1376300.0 True False 898047.8260047879 1912971.5302552509 1051246.2857882464 1.0 2.1301443808016653 1.1705905357680157 19.776432752925093 -6.606238136846227 2.1678750484614646 1.7569721748427924 1.1739302819703146 0.03874134956532238 0.48771477279570247 0.6231529269265038 5.544119739918 0.18615178238068325 0.5417324923562516 2.476063984294281e-07 6.606238136846227 -0.5830418928724779 NIFAILQSVK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIFAILQSVKAR 12 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3 A0A3B3IRP5 CDC73 Parafibromin 1 13982300.0 3419700.0 4315400.0 6247200.0 True False 2843632.068396764 4292152.083660164 7553460.636210788 1.0 1.5093908003647158 2.656272138775471 21.4393033790641 -6.957664731997312 0.46719079152535115 0.9688658834096641 3.24359120458484 0.9996735167378801 0.012515642618729924 0.08054622377595848 0.02429607290987561 0.015775071783355857 0.09467871677583092 1.102390007598052e-07 6.957664731997312 2.274725321175176 NIFHLFHDVVPTYHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIFHLFHDVVPTYHK 15 0 O43264;O43264-2 O43264 ZW10 Centromere/kinetochore protein zw10 homolog 0 10728900.0 1831900.0 2786300.0 6110700.0 False True 2401638.6401448334 2370594.900912337 5478423.381973425 1.0 0.9870739341408064 2.2811189370450182 21.195587663211235 -6.904645785373893 0.9314483421803091 0.9528390499358808 2.4305194117575817 0.9887387833394957 0.06441361866420932 0.10806539601005903 0.15876898437223244 0.051378220078646855 0.1370760281161894 1.2455300635345445e-07 6.904645785373893 1.477680361821701 up NIFHLFHDVVPTYHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIFHLFHDVVPTYHK 15 0 O43264;O43264-2 O43264 ZW10 Centromere/kinetochore protein zw10 homolog 0 8784200.0 2160400.0 1533000.0 5090800.0 False True 2091819.2845431704 2145134.8944893894 3757366.759273636 1.0 1.0254876749345307 1.7962195812217128 20.99632678966862 -6.9139331972081495 0.8685258704563643 0.9790012529456943 1.9046794756193672 0.9923229649296488 0.03237340205507882 0.10187432845145263 0.12508599369818368 0.027031116310028695 0.07681667549125912 1.219177117244927e-07 6.9139331972081495 0.925678222673673 NIFHLFHDVVPTYHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIFHLFHDVVPTYHK 15 0 O43264;O43264-2 O43264 ZW10 Centromere/kinetochore protein zw10 homolog 0 15796200.0 1831900.0 3238300.0 10726000.0 False True 2509202.935236062 3095221.198373932 8192739.708904117 1.0 1.2335475759686765 3.2650765682821734 21.258797724734126 -6.928572515086126 0.7584173093176161 0.9674153414407387 3.6673732549142737 0.9962502060848565 0.06228869123877797 0.0933857665530385 0.0813610379430922 0.05627351393127243 0.18528207106231998 1.1787656857626935e-07 6.928572515086126 2.699957913473535 up NIFHLFHDVVPTYHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIFHLFHDVVPTYHK 15 0 O43264;O43264-2 O43264 ZW10 Centromere/kinetochore protein zw10 homolog 0 9249500.0 2160400.0 2614200.0 4474900.0 False True 1796468.3219476447 2600116.785721925 5410580.9004001245 1.0 1.4473490870704602 3.011787535743593 20.776732065102895 -6.94796286293933 0.5807772463647829 0.9813535630094435 3.555266165043647 0.99903157443358 0.026840041967504814 0.08431420305633855 0.039428241091114466 0.02809775841389948 0.13071435501057171 1.1272938483515494e-07 6.94796286293933 2.5739126020342034 up NIFLLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIFLLFK 7 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 20259500.0 3986200.0 6892500.0 9380800.0 False True 5225946.802415714 5864165.866754578 8410164.802987587 1.0 1.1221250595287051 1.6093093024023812 22.31726100812645 -6.944937341263159 0.611915740164917 0.9946252394961288 1.7622633655583884 0.9987416147305277 0.009337077487058898 0.08558477275160903 0.044883953194271915 0.009473799260058454 0.041108412238260277 1.135174583524761e-07 6.944937341263159 0.7676381260622596 NIFLLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIFLLFK 7 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 9858400.0 4417600.0 2270700.0 3170100.0 False True 4277365.706071984 3177402.351544072 2339755.709038531 1.0 0.7428409375970714 0.5470085725232948 22.028291129304698 -7.098396500558793 0.1307008512031497 1.309052811675424 2.987544113463068e-11 0.9999990267935666 0.00018290399365630713 0.07648923149097699 0.004427747401152251 0.014312699547626385 0.02898623391048321 7.972664695234395e-08 7.098396500558793 -1.3090528116455487 NIFLLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIFLLFK 7 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 19275600.0 4509300.0 6188000.0 8578300.0 False True 6840937.77398807 5083703.052935332 6882795.244997552 1.0 0.7431295563402968 1.0061186744262811 22.705762676474347 -11.038074823508735 10.50844505557804 1.3150077228343102 0.874624115383209 0.2325602511906909 0.10736485786920212 0.048414942680915334 0.00017542004359655385 0.00635191154253402 0.03465185887461218 9.160626503854358e-12 11.038074823508735 -0.44038360745110117 NIFLLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIFLLFK 7 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 18750900.0 3986200.0 6110900.0 8653800.0 False True 5460005.863004532 5840900.23195604 6609950.670605477 1.0 1.0697607985244744 1.2106123759669654 22.380471069649342 -6.95985891724851 0.43741877902890874 0.9948260415015083 1.291015251559027 0.9997649236687098 0.0013430830754260373 0.0797515620509139 0.021317929423993957 0.001851265377810384 0.011676300433102263 1.0968344504743313e-07 6.95985891724851 0.29618921005751864 NIFLLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIFLLFK 7 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 8296100.0 4417600.0 2027300.0 1851200.0 False True 3673430.132862395 2016378.5325124573 2238277.3610182833 1.0 0.5489089106320536 0.6093153483428803 21.808696404738974 -10.336467648265762 5.73863329782019 1.000065523571607 0.579112129487662 0.9847862286698428 0.024660824928463516 2.0676799475976184e-05 2.390729003649101e-06 0.023881440394669 0.007959247020972008 4.6082109518290796e-11 10.336467648265762 -0.42095339408394494 NIFLLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIFLLFK 7 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 17007500.0 4509300.0 7378500.0 5119700.0 False True 5837377.741591738 6967879.988777224 4187967.132558127 1.0 1.1936661112626952 0.7174398022452032 22.476888998566796 -6.796269488876244 1.4708769560402 1.1073614110275 0.7114382249249935 0.8211224872045045 0.08270335708631733 0.22610768839249376 0.9660664538367744 0.04424049256139023 0.10313958099272624 1.5985657770448988e-07 6.796269488876244 -0.39592318610250654 NIFLVAATLRPETMFGQTNCWVRPDMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIFLVAATLRPETMFGQTNCWVRPDMK 27 2 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 42362000.0 10070000.0 16318000.0 15974000.0 False True 15276926.215612141 13405925.406884084 12816731.89834707 1.0 0.8775276660814135 0.8389601230939445 23.86485096023003 -13.999999999997417 0.16173593096485697 1.6054247685745644 0.8017632520327969 0.9995319030179061 0.001485363199483245 12.021754781259549 0.12714687343422207 2.282964899276215 0.03397715784200153 1.0000000000059472e-14 13.999999999997417 -0.8036615165417675 NIFNK(ub)THR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIFNKTHR 8 1 F8VVA7;P61923;P61923-4;P61923-3;P61923-5;F8VXB1;F8VUC5;F8W156;F8VXR1;F8VYZ4;F8VYE0 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 5169100.0 1291900.0 1290300.0 2586900.0 True False 1693693.4107773956 1097792.269550006 2319232.4032970136 1.0 0.6481646929512027 1.3693342540858675 20.691741313662455 -6.774013058907616 1.5588455350324029 0.7992391335423504 1.374047389107423 0.7457892932258687 0.14845720992390773 0.2599719242839717 1.2472144059672787 0.07503943383715965 0.17799372601247385 1.6826234650908712e-07 6.774013058907616 0.5748082555650725 NIFPIWALGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIFPIWALGR 10 0 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 0 9692300.0 2293200.0 3650400.0 3748700.0 False True 3006407.40738039 3105774.5491477554 3360820.484069543 1.0 1.0330517884979362 1.1178859112105395 21.51960909580421 -6.9548949660419055 0.5022410431623922 0.9983335433671752 1.1562770893143206 0.9995315167291852 0.001074638334058706 0.08157772622088393 0.028273570968730226 0.001255025172265205 0.00699863394724352 1.109443101217947e-07 6.9548949660419055 0.15794354594714544 NIFPIWALGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIFPIWALGR 10 0 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 0 9447900.0 3852300.0 2035400.0 3560200.0 False True 3730010.8451424083 2848145.8344707754 2627676.8162893876 1.0 0.7635757515772145 0.7044689480491485 21.83074839449917 -13.999999999999998 0.19467978337509984 2.2885421135892434 0.6640054334023661 0.9994875076272401 0.002890540320735994 12.430733500501812 0.1399209450469803 6.086244462964578 0.03918580302893409 1.0000000000000041e-14 13.999999999999998 -1.6245366801868775 NIFPIWALGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIFPIWALGR 10 0 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 0 16845700.0 2293200.0 3999500.0 10553000.0 False True 3141058.011399826 3822788.865422142 8060598.745857281 1.0 1.2170386065931014 2.5662049909944327 21.5828191573271 -6.935090790440718 0.7037574716599564 0.9828357322280794 2.8828703821252697 0.9974475016742814 0.03500427822784278 0.09007932235568362 0.06535472858604999 0.03291859153942366 0.11884562963293337 1.1612058352314889e-07 6.935090790440718 1.9000346498971903 up NIFPIWALGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIFPIWALGR 10 0 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 0 7999600.0 3852300.0 1711200.0 2436100.0 False True 3203358.1358261965 1701981.4259533954 2945477.2467462425 1.0 0.5313116279190018 0.9194967037260595 21.611153669933447 -10.019512244388793 7.114664046377938 1.0000000290303956 0.7254041658225309 0.4001880244439544 0.1584758935818169 7.30251481215905e-08 9.962683844234562e-09 0.15344364015981188 0.051147874718142916 9.560657395641493e-11 10.019512244388793 -0.2745958632078648 NIFPSNLVSAAFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIFPSNLVSAAFR 13 0 Q15758;M0QXM4;M0QX44 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 0 8983300.0 2350900.0 2874900.0 3757500.0 False True 3082052.6661479855 2445976.12627243 3368709.944485104 1.0 0.7936191854013522 1.0930085593557974 21.55546008417536 -6.721175849488034 1.7546668899821294 0.874604932134612 1.0925875251035324 0.5183076246313643 0.08683296869285594 0.35300838231859333 2.124624416381729 0.03928028323086664 0.09848764123058647 1.90030867316079e-07 6.721175849488034 0.21798259296892042 NIFPSNLVSAAFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIFPSNLVSAAFR 13 0 Q15758;M0QXM4;M0QX44 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 0 4966200.0 3327300.0 1638900.0 0.0 False True 3221676.6827719407 2293321.3167505963 0.0 1.0 0.711840927121655 0.0 21.619380286346185 -7.405324767306183 0.7584715789198854 0.9905047353794203 6.691991767700572e-18 0.987432309564427 0.04711631617308886 0.11353822273164771 0.13914275707752324 0.0408376789377269 0.07320784858656923 3.93255887005708e-08 7.405324767306183 -0.9905047353794203 down NIFPSNLVSAAFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIFPSNLVSAAFR 13 0 Q15758;M0QXM4;M0QX44 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 0 12217500.0 2350900.0 3050300.0 6816300.0 False True 3220091.2606836963 2915527.6600067955 5206430.326105079 1.0 0.9054177114805637 1.6168580032727515 21.61867014569825 -6.873398498593291 1.1159076877586238 0.9452287684183971 1.6613154812683641 0.9679614642535863 0.0564642789804222 0.1336407564274092 0.3089643258414166 0.03918113370156733 0.09335462448983707 1.3384479948128333e-07 6.873398498593291 0.716086712849967 NIGENEGGIDK(ub)FSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIGENEGGIDKFSR 14 1 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 1 6579400.0 2221000.0 1354700.0 3003700.0 True False 2911752.508194596 1152584.0405792403 2692905.9375249273 1.0 0.39583860143865346 0.9248402568371573 21.47345630453994 -10.380278343259851 8.52724486919569 1.0000017641146934 0.6603394291379115 0.3547081275131242 0.21596402146899277 7.243058576542117e-06 5.265588506026503e-07 0.20910735184242246 0.0697020882107825 4.166022937128705e-11 10.380278343259851 -0.3396623349767819 NIGENEGGIDK(ub)FSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIGENEGGIDKFSR 14 1 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 1 6753000.0 2221000.0 1774400.0 2757600.0 True False 3042163.720268191 1696001.140843871 2106311.6745547233 1.0 0.5574983126464854 0.6923728859566556 21.536666366062832 -10.732499000308625 10.255554940761357 1.0006772275948894 0.6249355993015727 0.9115885325533607 0.05506231398091994 0.0008539311199628634 2.2273457927602767e-05 0.053396465172922264 0.017771285420978902 1.8514031558980026e-11 10.732499000308625 -0.3757416282933167 NIGENEGGIDK(ub)FSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIGENEGGIDKFSR 14 1 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 1 7761000.0 1807700.0 3138400.0 2814900.0 True False 1503182.6446883706 3121492.816276377 3403482.5753729297 1.0 2.0765891805007524 2.2641843207806036 20.51958888435167 -10.67604102909584 0.34767656882149905 9.083477353320245e-11 2.298744588823482 0.9992254570534949 0.015502085980270162 2.2771274013127845 0.16896405928834685 1.992901753330483 0.05616340832831081 2.1084289509484577e-11 10.67604102909584 2.298744588732647 NIGGQIQEK(ub)VR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIGGQIQEKVR 11 1 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 1 4064000.0 1030200.0 1881100.0 1152700.0 True False 856656.945598253 1870966.1409308838 1393724.2405173818 1.0 2.184031951815064 1.6269339175719444 19.708358056874197 -10.193259005471232 5.217088709214792 0.9999440225580671 1.905482934693869 0.7788774212172986 0.227434320101867 0.00014809975753299053 2.2901291996941098e-05 0.22022584376602547 0.07340411117568593 6.408272846549431e-11 10.193259005471232 0.905538912135802 NIGISAHIDSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIGISAHIDSGK 12 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 14287100.0 6695700.0 5792800.0 1798600.0 False True 8778127.541251035 4928536.820157542 1612498.1253894654 1.0 0.5614565061850468 0.18369499848479717 23.06548180122071 -7.849996846879297 0.346758566722491 1.0793851430736705 2.0983245694997507e-23 0.9988050694886305 0.011530523914716486 0.11177556517162558 0.06118036789095457 0.04065995051893898 0.0822403981922601 1.4125478001468958e-08 7.849996846879297 -1.0793851430736705 down NIGISAHIDSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIGISAHIDSGK 12 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 9010800.0 4792800.0 1205800.0 3012200.0 False True 4640655.187446086 1687282.2281639287 2223214.455936994 1.0 0.36358707122398787 0.479073399366374 22.14589707488176 -9.987371892318842 5.9780237621855585 1.000000511582763 0.4213302352967792 0.9709946784871631 0.04714709603638887 3.2141061591929536e-07 5.4505375832402545e-08 0.04565001957432071 0.01521665981420245 1.0295041643499752e-10 9.987371892318842 -0.5786702762859839 NIGISAHIDSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIGISAHIDSGK 12 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 40673000.0 11539600.0 20183400.0 8950000.0 False True 17506416.857763477 16581514.576376023 7181028.57707564 1.0 0.9471678134422298 0.4101940811429443 24.061380493241526 -6.92593213143225 0.7794587540587975 1.0095134378182915 0.3105684067248065 0.9956765661446355 0.017520423402486912 0.09480574515095987 0.08843592636082495 0.015591312890552704 0.049717813856116864 1.1859540664671938e-07 6.92593213143225 -0.698945031093485 down NIGISAHIDSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIGISAHIDSGK 12 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 14697800.0 6695700.0 1758500.0 6243600.0 False True 9171281.234488843 1680803.6554181392 4768990.2709783465 1.0 0.18326814023513238 0.5199917164293724 23.1286918627436 -10.570338744840967 6.368898304014175 1.001189471718729 0.3516299283780901 0.8317499576437452 0.1374668243401768 0.002325313514357604 0.00015687083891076085 0.13330514196534568 0.04436722677712709 2.6894362553967352e-11 10.570338744840967 -0.6495595433406389 NIGISAHIDSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIGISAHIDSGK 12 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 9202390.0 4792800.0 1667800.0 2741790.0 False True 3985425.55704068 1658815.2303676188 3315085.612395376 1.0 0.41622035253855 0.8318021664057739 21.926302350316035 -9.849300415335593 5.804170324124715 1.0000000787623127 0.624011259471388 0.5218464487386065 0.16966056506199975 1.72977930953053e-07 3.416108946718252e-08 0.1642731700169378 0.054757711915691794 1.4148147689188698e-10 9.849300415335593 -0.37598881929092465 NIGISAHIDSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIGISAHIDSGK 12 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 51076300.0 11539600.0 33732100.0 5804600.0 False True 14938239.679522788 31854878.982100964 4748222.360225573 1.0 2.132438604915903 0.31785688689507346 23.832506815333975 -6.7379089699214125 1.6940981118174383 1.6753843625844482 0.31719393902683757 0.5957270742640781 0.4758284859347039 0.3215594136034856 1.811182469067229 0.22226409847589107 0.5467265821216714 1.8284834343388243e-07 6.7379089699214125 -1.3581904235576108 NIGK(ub)TLVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIGKTLVTR 9 1 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7;D6RI02;D6RGE0 P61247 RPS3A 40S ribosomal protein S3a 1 15946200.0 4279900.0 6419600.0 5246700.0 True False 5610990.346610553 5461820.703404816 4703821.813900205 1.0 0.973414738933592 0.838322920434475 22.41982400005962 -6.939445368000082 0.6647032817708103 1.0015318089946676 0.8024797497234625 0.9980903404621456 0.0030933227267635564 0.0880205994998562 0.05576877861411146 0.002998610539123593 0.011655787814523231 1.1496208506821009e-07 6.939445368000082 -0.19905205927120517 NIGK(ub)TLVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIGKTLVTR 9 1 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7;D6RI02;D6RGE0 P61247 RPS3A 40S ribosomal protein S3a 1 39399800.0 8575800.0 10688000.0 20136000.0 True False 8303565.923155594 14955774.137183685 14861777.532948457 1.0 1.8011266816678757 1.7898066530072847 22.985299596729124 -10.144800833176692 5.1287644665287955 0.9999673030768134 1.7954666673385125 0.9998481387168425 0.004621382351934455 1.7278689419729034e-06 2.881114376231346e-07 0.004474817504745523 0.0014915447399919774 7.164719078669282e-11 10.144800833176692 0.7954993642616991 NIGK(ub)TLVTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIGKTLVTR 9 1 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7;D6RI02;D6RGE0 P61247 RPS3A 40S ribosomal protein S3a 1 14940200.0 4185600.0 3068600.0 7686000.0 True False 6349861.208348183 2520984.354918772 6166858.731106534 1.0 0.39701408774170144 0.9711800823298223 22.598293627946603 -10.816666276852164 10.3403662134797 1.0040162042991927 0.6840970850357625 0.28755570164340327 0.23440228573308397 0.021779689695732442 0.0003861510183541123 0.22776315311541276 0.07565301241309887 1.5252243255508758e-11 10.816666276852164 -0.3199191192634302 NIGK(ub)TLVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIGKTLVTR 9 1 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7;D6RI02;D6RGE0 P61247 RPS3A 40S ribosomal protein S3a 1 14762900.0 4279900.0 5274000.0 5209000.0 True False 5862294.689948588 5040977.241214245 3978741.4827224994 1.0 0.8598983005507105 0.6787003542391679 22.48303406158251 -6.967604047959481 0.31013475951162284 1.0278706712587924 0.5049672066677438 0.9999571936133868 0.000860518264410075 0.07708814489867956 0.011799585674756701 0.0028651688136653503 0.016084799687685773 1.0774470887718137e-07 6.967604047959481 -0.5229034645910486 NIGK(ub)TLVTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIGKTLVTR 9 1 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7;D6RI02;D6RGE0 P61247 RPS3A 40S ribosomal protein S3a 1 35879200.0 8575800.0 22899000.0 4404400.0 True False 7131157.672356337 22775638.541904386 5325339.6763553005 1.0 3.193820637312969 0.746770709754291 22.7657048721634 -6.670396801630858 1.9358603853638785 2.3998486806938484 0.7566323221493847 0.28077766436006024 0.931806512497955 0.4602531144479032 3.3256498005387263 0.3874419747191223 1.0346524815518605 2.1360095908110464e-07 6.670396801630858 -1.6432163585444637 NIGK(ub)TLVTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIGKTLVTR 9 1 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;H0Y8L7;D6RAS7;D6RED7;D6RI02;D6RGE0 P61247 RPS3A 40S ribosomal protein S3a 1 10502300.0 4185600.0 3293100.0 3023600.0 True False 5418341.710510805 3109836.090132447 2473335.8247558945 1.0 0.5739460994310882 0.45647468485754195 22.369419950039052 -13.999999999999998 0.18077345979438697 3.215867959081162 0.3639023894953278 0.9994972255545058 0.0052359001004278986 12.214834150454472 0.13478999177947085 9.508597841579538 0.08713516011595164 1.0000000000000041e-14 13.999999999999998 -2.851965569585834 NIGVDNPAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIGVDNPAAK 10 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 8177200.0 2345300.0 964900.0 4867000.0 False True 2270849.7352523156 1350189.6018870268 3592186.693129725 1.0 0.5945746127217908 1.5818689530025616 21.114800813731527 -6.795199163795264 1.4754363663326846 0.7749299987001429 1.5939354797914955 0.8177512841168398 0.1729827700090274 0.22768443908461594 0.9789540523290919 0.09225652042841537 0.21521203944445785 1.6025103244040055e-07 6.795199163795264 0.8190054810913526 NIGWGTDQGIGGFGEEPGIK(ub)SQLMNLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIGWGTDQGIGGFGEEPGIKSQLMNLIR 28 1 A0A1W2PNR9;Q9Y5U9 A0A1W2PNR9 IER3IP1 Immediate early response 3-interacting protein 1 1 86290000.0 13578000.0 54967000.0 17745000.0 True False 20598818.68476483 45157709.390868805 14237692.972090222 1.0 2.1922475304017346 0.69118978083052 24.296058267323932 -6.695080185042914 1.8486862710296574 1.7438695439868854 0.6960676858187246 0.3942523125325814 0.5037265696774711 0.4057837361492033 2.692654309064496 0.2176828566780541 0.5631911876535901 2.017993741278099e-07 6.695080185042914 -1.0478018581681607 NIGWGTDQGIGGFGEEPGIK(ub)SQLMNLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIGWGTDQGIGGFGEEPGIKSQLMNLIR 28 1 A0A1W2PNR9;Q9Y5U9 A0A1W2PNR9 IER3IP1 Immediate early response 3-interacting protein 1 1 55656000.0 13578000.0 28561000.0 13517000.0 True False 17576988.66239386 26971555.242863223 11057044.696132226 1.0 1.534481005871565 0.6290636529674096 24.06718458941638 -6.746760800218906 1.6618084909609672 1.3155079021144507 0.6277005271942152 0.6348701671626755 0.22456688141464168 0.30575777684684086 1.6602755972977452 0.10679613690216866 0.26016254266944466 1.7915923517237237e-07 6.746760800218906 -0.6878073749202355 NIHESCMSQIGWNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIHESCMSQIGWNR 14 0 P11413;P11413-3;P11413-2;E9PD92 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 5766000.0 1511900.0 2379400.0 1874700.0 False True 2070890.2875612215 2274270.240376412 1431934.4706584509 1.0 1.0982089461893707 0.6914583931651757 20.981819693242798 -6.842939116270456 1.2687277563242407 1.0522406377115876 0.6772870283413407 0.9293819866336868 0.04605222540104742 0.1653944954798579 0.5158882949862307 0.028448031270595447 0.06559768392334486 1.4356906886781192e-07 6.842939116270456 -0.3749536093702469 NIHIFGLANVLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIHIFGLANVLHR 13 0 Q96JH7 Q96JH7 VCPIP1 Deubiquitinating protein VCIP135 0 7443400.0 2431500.0 1917300.0 3094600.0 False True 2354313.3634358076 2682887.8885874143 2284031.4239899814 1.0 1.1395627830409525 0.9701475850507602 21.166874927842688 -6.687895996855382 1.8741200605092652 1.087671787018086 0.9707517255483873 0.3604427834045558 0.05905116238161965 0.4212352427043959 2.866907784607434 0.025223385099316823 0.06585265890299871 2.051653441945508e-07 6.687895996855382 -0.1169200614696988 NIHIFGLANVLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIHIFGLANVLHR 13 0 Q96JH7 Q96JH7 VCPIP1 Deubiquitinating protein VCIP135 0 7927800.0 1548800.0 2032500.0 4346500.0 False True 2121433.214746229 1942697.4294213054 3319946.21897741 1.0 0.9157476256699864 1.564954388335317 21.016607830903084 -6.874273391523833 1.1113137333386998 0.9508725432219693 1.6061828171225077 0.9687617531581457 0.05094455416584789 0.132819916992729 0.30401312286862237 0.03547795853580534 0.08467245129536045 1.3357543847590827e-07 6.874273391523833 0.6553102739005383 NIHLNLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIHLNLDR 8 0 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 56817000.0 17156000.0 19352000.0 20309000.0 False True 22491682.138940327 16464757.033505196 18207619.497684117 1.0 0.7320376009137801 0.8095268012951721 24.422888227628516 -10.058803076785967 6.867582606018376 1.0000000787953736 0.770782201104476 0.9210536779175714 0.031634833585115665 3.818382377061087e-08 5.183968006155544e-09 0.030630306406573708 0.010210098636266233 8.733672916961106e-11 10.058803076785967 -0.22921787769089752 NIHLNLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIHLNLDR 8 0 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 40512100.0 17434000.0 6157100.0 16921000.0 False True 16880567.212889142 8615662.138852334 12488882.480881035 1.0 0.5103893743732647 0.7398378456942585 24.008860045832098 -10.029591302818366 4.979590584887537 1.0000055164746882 0.6251136100303062 0.7806693272601365 0.093671946178318 129498447.79387698 11.193613933156202 8190.904958414311 0.03206639870272964 9.34132962496605e-11 10.029591302818366 -0.374891906444382 NIHLNLDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIHLNLDR 8 0 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 60390600.0 12870000.0 39735000.0 7785600.0 False True 19524730.923031606 32643978.799028 6246772.747450299 1.0 1.6719297657782712 0.3199415537184961 24.218799330443947 -6.771579877660226 1.5683968172659482 1.3846319612663829 0.31188376935118345 0.736535782273174 0.28330922515679147 0.263901962813664 1.2813623032365096 0.14236202048158483 0.3383932154247508 1.6920770003665817e-07 6.771579877660226 -1.0727481919151995 NIHLNLDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIHLNLDR 8 0 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 65270000.0 17156000.0 22271000.0 25843000.0 False True 23499036.823467385 21286993.579651587 19739415.653291896 1.0 0.9058666420911884 0.8400095630123473 24.486098289151407 -6.9749543940751835 0.07331701357855525 1.2628981903850145 0.48133049848765846 0.9999999221814518 1.738129552498567e-05 0.07472570896042056 0.002119555911276313 0.008832889662182649 0.013684041922929178 1.0593649648644486e-07 6.9749543940751835 -0.781567691897356 NIHLNLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIHLNLDR 8 0 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 25190300.0 17434000.0 7756300.0 0.0 False True 14497143.457153903 7714515.272394997 0.0 1.0 0.5321403692524072 0.0 23.789265321266374 -7.832814525879753 0.6133752155263434 1.0059407808503067 8.71074778593088e-18 0.988283040664639 0.04422121916846854 0.11560203827832703 0.1572415238301806 0.04367827475229457 0.07771851640256142 1.469553745884489e-08 7.832814525879753 -1.0059407808503067 down NIHLNLDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIHLNLDR 8 0 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 35086300.0 12870000.0 13681000.0 8535300.0 False True 16660468.705627399 12919640.323434455 6981962.979573678 1.0 0.7754667981862116 0.41907362289365746 23.989925652536396 -6.9643006311456785 0.36986186037717816 1.0274498530241973 0.15468781272357615 0.9998979903660417 0.002415807778704015 0.07819913018663092 0.015701875433116998 0.00469851662899657 0.030270482382730685 1.0856738287543297e-07 6.9643006311456785 -0.8727620403006212 down NIHLNLDRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIHLNLDRR 9 1 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 11256600.0 4400200.0 2291700.0 4564700.0 False True 5768704.811597411 1949787.2929766357 4092388.631694259 1.0 0.33799394433509256 0.7094120370775284 22.45981601096195 -10.71489702544725 6.95149368174629 1.0049657668884493 0.5237029907066086 0.6867800890736767 0.15163080140944799 0.01171712397647591 0.0004805560081685708 0.14741454613113988 0.04893863071923968 1.9279819983192533e-11 10.71489702544725 -0.48126277618184066 NIHLNLDRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIHLNLDRR 9 1 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 4859040.0 1681900.0 872440.0 2304700.0 False True 1628509.0051255121 1220809.8417144965 1701029.9304820385 1.0 0.7496488124242251 1.0445320996864473 20.63512026671473 -6.681741832380505 1.8954953577124394 0.8418509168212032 1.0434311895416635 0.33221369813186863 0.10606413439956368 0.4346598488714524 3.020803427269703 0.04487287802757762 0.11809456658175915 2.0809333363841863e-07 6.681741832380505 0.2015802727204603 NIHLNLDRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIHLNLDRR 9 1 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 38253700.0 6584700.0 16208000.0 15461000.0 False True 9989471.306051763 13315555.766318006 12405126.573202958 1.0 1.3329590083762746 1.2418201317308712 23.251976894556975 -10.119978494878094 4.48382136297685 0.9999680021270105 1.2873895700635778 0.9298632412501302 0.037207290623300755 1.2109897857747786e-05 2.376603876989284e-06 0.036029880360125194 0.012008601406445834 7.586151387280305e-11 10.119978494878094 0.28742156793656726 NIHLNLDRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIHLNLDRR 9 1 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 10941100.0 4400200.0 3865900.0 2675000.0 False True 6027072.85093385 3695091.755178269 2043220.0933543267 1.0 0.6130823115246968 0.33900703440771335 22.523026072484843 -8.04485702828099 0.20500786229949844 1.247331522517024 1.1393252255817174e-12 0.9998123779940328 0.003714171188185087 0.09769677916686206 0.03743768813467767 0.0827129139970824 0.10490062543163171 9.018679877851576e-09 8.04485702828099 -1.2473315225158847 down NIHLNLDRR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIHLNLDRR 9 1 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 4940760.0 1681900.0 2311500.0 947360.0 False True 1398574.3708034353 2299047.4907031744 1145448.5959022709 1.0 1.6438507230634054 0.8190115733668478 20.415525542149005 -6.698404244552847 1.836316632500701 1.4004183277491713 0.8215153941891118 0.4101491644921361 0.2718560287622478 0.3988342095005292 2.613479719476082 0.11815068346262603 0.30447988546982696 2.0026071178765113e-07 6.698404244552847 -0.5789029335600595 NIHLNLDRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIHLNLDRR 9 1 Q9Y5S9;Q9Y5S9-2;A0A0J9YW13 Q9Y5S9 RBM8A RNA-binding protein 8A 0 37279700.0 6584700.0 16328000.0 14367000.0 False True 8524023.953841858 15419332.446534475 11752353.417868726 1.0 1.80892645656924 1.3787330351848472 23.023103216649424 -10.062881541148775 4.231083851392722 0.9999380053406726 1.5938297459940332 0.7175614380898505 0.1756257293076217 27066978.5586801 59758361.81152967 23907.006069541265 0.06427243226037067 8.65203880975411e-11 10.062881541148775 0.5938917406533606 NIHLWTPTDGGSWHVDQRPFVGHTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIHLWTPTDGGSWHVDQRPFVGHTR 25 1 Q9BQ67;M0QX71 Q9BQ67 GRWD1 Glutamate-rich WD repeat-containing protein 1 0 15236100.0 3802700.0 4708200.0 6725200.0 False True 4985376.525399186 4005754.912419856 6029340.816673649 1.0 0.8035009777118309 1.209405304886349 22.249271039005293 -6.7750684019148455 1.5550468255784877 0.8880244829695985 1.212139264805378 0.7495654057779353 0.0829408310295905 0.25831363835215565 1.233382914191007 0.04202448396261854 0.0995782437566197 1.6785396252473393e-07 6.7750684019148455 0.32411478183577946 NIHLWTPTDGGSWHVDQRPFVGHTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIHLWTPTDGGSWHVDQRPFVGHTR 25 1 Q9BQ67;M0QX71 Q9BQ67 GRWD1 Glutamate-rich WD repeat-containing protein 1 0 15681200.0 3636900.0 1735300.0 10309000.0 False True 3521448.600238409 2428214.3394699544 7608763.636629208 1.0 0.6895498458519485 2.160691380278582 21.7477375943424 -6.851584934730295 1.2274850317768284 0.8340874070800698 2.221301778145925 0.9425706621808588 0.15172926560713695 0.15572342217143928 0.45072364054564157 0.09668578057705732 0.22396578297943595 1.4073919585833374e-07 6.851584934730295 1.387214371065855 up NIHLWTPTDGGSWHVDQRPFVGHTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIHLWTPTDGGSWHVDQRPFVGHTR 25 1 Q9BQ67;M0QX71 Q9BQ67 GRWD1 Glutamate-rich WD repeat-containing protein 1 0 13995200.0 3802700.0 6853000.0 3339500.0 False True 5208660.954103489 6550211.800159516 2550778.879161411 1.0 1.2575615609994975 0.4897187399290897 22.312481100528185 -6.816229172009682 1.3879743971247553 1.139375727985936 0.47425456340877326 0.875527935321648 0.11257327915937126 0.19842095350190483 0.7520769803953022 0.06374955995391893 0.1471101626526715 1.526760192520184e-07 6.816229172009682 -0.6651211645771627 down NIHLWTPTDGGSWHVDQRPFVGHTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIHLWTPTDGGSWHVDQRPFVGHTR 25 1 Q9BQ67;M0QX71 Q9BQ67 GRWD1 Glutamate-rich WD repeat-containing protein 1 0 29064800.0 5204800.0 12199000.0 11661000.0 False True 6737716.201946346 11520114.926217169 9538817.651964037 1.0 1.7097952156087126 1.4157345554579053 22.6838282315821 -10.083985641238637 4.67400338430023 0.9999730928241732 1.5627648853232772 0.8300291381109669 0.12004976184987222 3.6825296553321146e-05 7.216992981163565e-06 0.11624374987831723 0.03874589402281725 8.24165363340212e-11 10.083985641238637 0.5627917924991039 NIHVCLGGLFVPEAYITATR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIHVCLGGLFVPEAYITATR 20 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 141831000.0 41678000.0 44409000.0 55744000.0 False True 63228573.06993876 36483866.980899304 44726173.9665368 1.0 0.577015504375586 0.7073728188846524 25.914073325631524 -10.735650549301694 10.227533027982638 1.0007079534211263 0.6421941616301204 0.9094637264440504 0.05321815079778649 0.0008605482920252401 2.224242766541134e-05 0.05161586097061931 0.01717608431298184 1.8380166901920915e-11 10.735650549301694 -0.35851379179100584 NIHVCLGGLFVPEAYITATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIHVCLGGLFVPEAYITATR 20 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 87000000.0 41678000.0 19066000.0 26256000.0 False True 53952992.59620351 18004960.339639038 21477677.409310337 1.0 0.3337156934814026 0.3980812995871085 25.685199647723973 -10.134430574492054 5.13016921017409 1.0000229954101243 0.36589849653342144 0.992331538536446 0.026277148660229538 6.911425619864318e-06 1.166136735714573e-06 0.025443660472742904 0.008480913261823228 7.337860067089944e-11 10.134430574492054 -0.6341244988767029 NIHYNSVVNPNK(ub)ATIGVGLGLPSFKPGFAEQSLMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIHYNSVVNPNKATIGVGLGLPSFKPGFAEQSLMK 35 2 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 149091000.0 20756000.0 84061000.0 44274000.0 True False 31488369.4668566 69059657.77840929 35523224.494016424 1.0 2.1931798612531757 1.1281379472953261 24.908315717874633 -6.618906847396074 2.1209912602761984 1.792318462213081 1.1321930288100677 0.07906941663045752 0.51325265108757 0.5883289260500273 5.027791178392481 0.198953406466128 0.5690908743129517 2.404878571417354e-07 6.618906847396074 -0.6601254334030133 NIIGVIPYFPYSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIIGVIPYFPYSK 13 0 Q14558;Q14558-2;C9JNQ3;C9J168;B4DP31;C9JUN4;C9JKT9 Q14558 PRPSAP1 Phosphoribosyl pyrophosphate synthase-associated protein 1 0 7686100.0 1855400.0 2030600.0 3800100.0 False True 2432447.367719156 1727642.395216805 3406902.105133164 1.0 0.7102486237294298 1.4006067100755932 21.213977158235164 -6.792685549249669 1.485507386160695 0.8386212799248806 1.4085098884130982 0.8099288731039866 0.12340002822067958 0.2313726371364992 1.0085677624198586 0.06537437861717417 0.15276870832984657 1.6118122448132384e-07 6.792685549249669 0.5698886084882177 NIIGVIPYFPYSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIIGVIPYFPYSK 13 0 Q14558;Q14558-2;C9JNQ3;C9J168;B4DP31;C9JUN4;C9JKT9 Q14558 PRPSAP1 Phosphoribosyl pyrophosphate synthase-associated protein 1 0 7545800.0 2463700.0 1735900.0 3346200.0 False True 2385491.1920611975 2429053.9225989114 2469729.8361517712 1.0 1.018261534849799 1.0353129134875518 21.18585492879957 -6.971951643839386 0.20632668806589358 0.9906434118219236 1.0634050911733801 0.9999937072807218 3.570738893239442e-05 0.07567441007098824 0.006714748840626464 0.0005258234017121716 0.0017822640867637151 1.0667148871068124e-07 6.971951643839386 0.0727616793514565 NIIGVIPYFPYSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIIGVIPYFPYSK 13 0 Q14558;Q14558-2;C9JNQ3;C9J168;B4DP31;C9JUN4;C9JKT9 Q14558 PRPSAP1 Phosphoribosyl pyrophosphate synthase-associated protein 1 0 9398400.0 1855400.0 2706100.0 4836900.0 False True 2541391.520299682 2586535.554123983 3694523.83908245 1.0 1.0177635100549078 1.4537405234777798 21.277187219758055 -6.915476222616692 0.8576097955720215 0.9887248225407953 1.5172166768588013 0.9928291678336505 0.01776888487691218 0.10090716323916307 0.11994897365672724 0.01495363970624624 0.04302652380279013 1.2148531311892586e-07 6.915476222616692 0.528491854318006 NIIGVIPYFPYSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIIGVIPYFPYSK 13 0 Q14558;Q14558-2;C9JNQ3;C9J168;B4DP31;C9JUN4;C9JKT9 Q14558 PRPSAP1 Phosphoribosyl pyrophosphate synthase-associated protein 1 0 5410600.0 2463700.0 974500.0 1972400.0 False True 2048675.7104158553 969250.1750768942 2384819.7206527977 1.0 0.47311059048976994 1.1640786819153088 20.966260204233848 -6.702856000527693 1.820431477141136 0.6737511024821885 1.16215574301652 0.43128170520456566 0.22229142748311276 0.38959848374070405 2.5119911217931903 0.09733856439461659 0.2494738585580715 1.9821841517144686e-07 6.702856000527693 0.4884046405343314 NIIGYFEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIIGYFEQK 9 0 Q9BS26 Q9BS26 ERP44 Endoplasmic reticulum resident protein 44 0 13441200.0 3049300.0 3735500.0 6656400.0 False True 3997661.8294632067 3178177.960864957 5967659.580697443 1.0 0.7950092069923065 1.4927874931078804 21.930725005991235 -6.8280729392595365 1.3367622704683249 0.8903161588627668 1.5108008193365823 0.9019109985368534 0.09171253642852452 0.18320557642459928 0.6409799867501516 0.05388224670309544 0.12399511276969688 1.4856861020577646e-07 6.8280729392595365 0.6204846604738155 NIIGYFEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIIGYFEQK 9 0 Q9BS26 Q9BS26 ERP44 Endoplasmic reticulum resident protein 44 0 10017400.0 3049300.0 2582500.0 4385600.0 False True 4176708.6142340363 2468396.610814524 3349811.60426719 1.0 0.5909908587834781 0.8020218582764386 21.993935067514126 -10.542900385795486 7.395906341755984 1.000126321568185 0.6965063585300346 0.7338790459786766 0.08615304477788145 0.00017952555043319914 1.1095447459257362e-05 0.08345166067014921 0.02780577563748304 2.8648350022788012e-11 10.542900385795486 -0.3036199630381504 NIIHGSDSVESAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIIHGSDSVESAEK 14 0 P15531;P15531-2 P15531 NME1 Nucleoside diphosphate kinase A 0 67783730.0 3346330.0 39153000.0 25284400.0 False True 4387071.035905821 33311525.017198626 22668212.833090942 1.0 7.5931127498419055 5.167049415786476 22.06482663613706 -9.763285984735628 8.85573983163468 1.0000066395164666 6.380081082814191 0.8676741878978896 0.9904362086926076 0.0 0.0 0.9589857068536575 0.31966191181115616 1.7247017946121487e-10 9.763285984735628 5.380074443297724 NIIHGSDSVESAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIIHGSDSVESAEK 14 0 P15531;P15531-2 P15531 NME1 Nucleoside diphosphate kinase A 0 73363200.0 19763200.0 6277000.0 47323000.0 False True 19135828.033828765 8783438.83412258 34927686.64043104 1.0 0.4590049000542339 1.8252508633901317 24.18977299398471 -6.799284134357067 1.4589775484887169 0.7012397264019872 1.843749288622161 0.830027062493361 0.2316082408481503 0.22177843074445022 0.9320998556620016 0.12489413275561624 0.29056667743694875 1.5875077920598378e-07 6.799284134357067 1.1425095622201737 NIIHGSDSVESAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIIHGSDSVESAEK 14 0 P15531;P15531-2 P15531 NME1 Nucleoside diphosphate kinase A 0 59284130.0 3346330.0 27557700.0 28380100.0 False True 4583558.63216797 26340109.692872595 21677304.886506613 1.0 5.746650540916945 4.72936131641748 22.12803669765995 -9.919473326744844 5.882835783922237 0.9999981361966354 5.2380059286697 0.9585758582364647 0.4153065868180492 1.0155603881815515e-05 1.8700832217109373e-06 0.40211906505540207 0.1340396245250881 1.2037233171252252e-10 9.919473326744844 4.238007792473065 NIIHGSDSVESAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIIHGSDSVESAEK 14 0 P15531;P15531-2 P15531 NME1 Nucleoside diphosphate kinase A 0 22570380.0 19763200.0 1850400.0 956780.0 False True 16433976.458209477 1840431.5279243565 1156838.27434911 1.0 0.11198942219519743 0.07039308333505732 23.970178269418987 -13.217185559537134 0.44464889277529757 9.999818953267791 0.07020192792326907 0.9998805181175955 0.004686599590275921 16.730995827545485 0.22535930545835547 143.92769499266367 0.00950900578161946 6.064771467792883e-14 13.217185559537134 -9.929617025344522 NIIHGSDSVESAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIIHGSDSVESAEK 14 0 P15531;P15531-2 P15531 NME1 Nucleoside diphosphate kinase A 0 11079500.0 4843500.0 6236000.0 0.0 False True 6270006.2296586195 5888961.118115441 0.0 1.0 0.9392273153189634 0.0 22.58003544576347 -7.075814709324883 1.018529334369163 1.0056435215949853 4.7032828137232354e-21 0.9889166533754822 0.048191092038728775 0.08437169484660197 0.1673734564697314 0.03919559822373814 0.06964306865102414 8.398182164764756e-08 7.075814709324883 -1.0056435215949853 down NIIHGSDSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIIHGSDSVK 10 0 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 59964500.0 2159500.0 32683000.0 25122000.0 False True 2831125.41262775 27806823.797336202 22522616.42724013 1.0 9.82182692201081 7.9553580801408 21.432944228199982 -9.36375115161693 8.226042474161362 1.0000231432911053 8.888592501081154 0.9597058632847875 0.7619827140341335 0.0 0.0 0.7377866013199825 0.2459288634421199 4.327617301304239e-10 9.36375115161693 7.888569357790049 NIIHGSDSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIIHGSDSVK 10 0 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 37482900.0 11288000.0 4912900.0 21282000.0 False True 10929668.618738811 6874646.590435037 15707605.753685398 1.0 0.6289894808565853 1.4371529733989243 23.381746324201256 -6.781876553461185 1.528477106372641 0.7904349549059728 1.4439442214906772 0.7739888794237821 0.1570264465259911 0.24767643027155573 1.143004672468845 0.08090406370052802 0.1906089452309969 1.6524314287689e-07 6.781876553461185 0.6535092665847044 NIIHGSDSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIIHGSDSVK 10 0 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 40961500.0 2159500.0 19981000.0 18821000.0 False True 2957925.5082931835 19098173.351668913 14375867.43066234 1.0 6.456610654366736 4.860118143731642 21.496154289722874 -9.74128135489245 7.054667520460205 0.9999999745483863 5.658364399049465 0.9190413649753412 0.6517653382061265 6.178184827228285e-08 1.5995643143593123e-08 0.631069075126447 0.21035635837548436 1.814339873509332e-10 9.74128135489245 4.6583644245010785 NIIHGSDSVK(ub)SAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIIHGSDSVKSAEK 14 1 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 1 189647120.0 85530000.0 77320120.0 26797000.0 True False 112130658.27369824 65784259.4874672 24024303.494974695 1.0 0.5866750494489675 0.21425276427374654 26.74060554653943 -7.738124296746084 0.3304553667713741 1.0823170354988938 3.7548210107440657e-13 0.9991902861262977 0.00913206499193697 0.12081688327726935 0.050374357422703304 0.03454576577903808 0.07869401232877646 1.827577081715887e-08 7.738124296746084 -1.0823170354985183 down NIIHGSDSVK(ub)SAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIIHGSDSVKSAEK 14 1 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 1 200085730.0 84415460.0 87802270.0 27868000.0 True False 81735737.42898662 122862174.29378924 20568534.777920537 1.0 1.5031634650697798 0.25164677563215015 26.28446367206225 -6.797566576730568 1.4657338100436192 1.2784731824679227 0.23536653824618142 0.8250042166041855 0.2150975164399727 0.22423308834707045 0.9512856461960517 0.11546102584224484 0.2689387718079235 1.5937985349198462e-07 6.797566576730568 -1.0431066442217414 down NIIHGSDSVK(ub)SAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIIHGSDSVKSAEK 14 1 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 1 390954300.0 202425300.0 110250000.0 78279000.0 True False 307093979.3717135 90575026.11281826 62807121.3390954 1.0 0.29494237007878354 0.20452084885412955 28.194104987414914 -13.999999999999998 0.2895560134470658 7.060290345073376 0.1797702736016674 0.9996264688279718 0.006872684210363113 15.93935821296909 0.17063336787376354 57.5256521993286 0.03421847751870777 1.0000000000000041e-14 13.999999999999998 -6.880520071471709 NIIHGSDSVK(ub)SAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIIHGSDSVKSAEK 14 1 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 1 178245160.0 85530000.0 67824160.0 24891000.0 True False 117152752.361341 64827464.34669583 19012258.446236484 1.0 0.5533584404977934 0.16228605869707505 26.803815608062322 -7.8605906872920555 0.36888135891406915 1.0677905114263095 1.5057995870915316e-20 0.9984332059063986 0.013547036722122695 0.10990142538218493 0.06772854040074969 0.03952288787461429 0.08151316425270369 1.3785080694650611e-08 7.8605906872920555 -1.0677905114263095 down NIIHGSDSVK(ub)SAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIIHGSDSVKSAEK 14 1 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 1 249503130.0 84415460.0 142239670.0 22848000.0 True False 70195195.22895695 141473396.66534597 27625411.162784018 1.0 2.0154284948407026 0.393551311776792 26.064868947496528 -6.737434814517795 1.6960786390282911 1.6059645691461013 0.3931221468807725 0.5933716991775033 0.4266734464114184 0.32247967812739703 1.8204707537079827 0.19909446864525174 0.48994416309904404 1.8304808319324564e-07 6.737434814517795 -1.2128424222653287 NIIHGSDSVK(ub)SAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIIHGSDSVKSAEK 14 1 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 1 409807000.0 202425300.0 134584700.0 72797000.0 True False 262043541.24920282 127094943.13554056 59548692.96029718 1.0 0.48501459921377554 0.22724732186269192 27.965231309507363 -9.37750707249461 0.2102658720976871 1.4551603699197655 2.3906040910479543e-20 0.9994327217946116 0.0076513474260881285 0.7961263589266488 0.08007892329314177 0.3720047468734235 0.13551522960249 4.192691688219328e-10 9.37750707249461 -1.4551603699197655 NIIIALIDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIIIALIDR 9 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 7188100.0 1777700.0 3649500.0 1760900.0 False True 2330581.9152712906 3105008.825639584 1578698.9597455277 1.0 1.3322890756569468 0.6773840255950668 21.152258790923952 -6.768779040328808 1.579237199948376 1.1908892867921002 0.6738785369347864 0.7258355930077576 0.1399987121025074 0.2684050006944783 1.320916228087774 0.06988520865799547 0.16653541004301542 1.7030247502979802e-07 6.768779040328808 -0.5170107498573138 NIIIALIDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIIIALIDR 9 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 9727300.0 5382900.0 1741500.0 2602900.0 False True 5212022.785950485 2436890.031802525 1921122.4046737931 1.0 0.46755168422735977 0.3685943986761466 22.31341196042629 -13.999999999999998 0.23664891023209828 4.467940822790321 0.32342650714935406 0.9995195596550304 0.0060777230921298915 13.507523498434399 0.15398603253818707 22.09387651721048 0.04932518206120508 1.0000000000000041e-14 13.999999999999998 -4.144514315640967 NIIIALIDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIIIALIDR 9 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 18650600.0 3767400.0 8884800.0 5998400.0 False True 5715421.2338328995 7299238.022740755 4812813.610807882 1.0 1.2771128713194968 0.8420750481728347 22.446428400146544 -6.734595658535569 1.7064371780139846 1.1658982146471661 0.842104296981477 0.5805512017936467 0.11645471087198328 0.3276392206838808 1.8710682460206953 0.054036427905896085 0.13339765100348372 1.8424866146372022e-07 6.734595658535569 -0.3237939176656891 NIIIALIDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIIIALIDR 9 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 10172600.0 1777700.0 3191200.0 5203700.0 False True 2434963.7305361396 3050202.2321128026 3974693.2335655754 1.0 1.2526684458832564 1.632341863544067 21.215468852446843 -6.965228050922641 0.35412067138126474 0.9650056874803077 1.9328975867937515 0.9999177644786439 0.0023567048304221237 0.07788369841024134 0.01458782693824234 0.005159546362860201 0.03254673067730606 1.0833578861984312e-07 6.965228050922641 0.9678918993134438 NIIIALIDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIIIALIDR 9 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 8095400.0 5382900.0 1299400.0 1413100.0 False True 4476119.852903153 1292399.874289294 1708572.6765638145 1.0 0.2887321869746317 0.381708428887501 22.093817235860566 -10.742410513973542 6.998228638481633 1.0104714693506656 0.3352203079310664 0.9855414527883207 0.03795739181468346 0.006124610222019612 0.00022543323341319042 0.036296644027270654 0.012250695530311561 1.809628744379397e-11 10.742410513973542 -0.6752511614195992 NIIIALIDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIIIALIDR 9 0 Q96QK1 Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 0 13492000.0 3767400.0 5872400.0 3852200.0 False True 4876973.566556393 5545595.777745529 3151139.1269098576 1.0 1.1370977722278792 0.6461259393568666 22.217554722238994 -6.832191114291012 1.3181990886415005 1.0731501452780836 0.6323231201369296 0.9101671746325063 0.061996831411333525 0.17812295597470656 0.6045695283375413 0.036919678562548096 0.08495656783995868 1.471664743667055e-07 6.832191114291012 -0.440827025141154 NIILEEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIILEEGK 8 0 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 74278200.0 5482200.0 27646000.0 41150000.0 False True 7187217.289700312 23521324.563263964 36892192.738672584 1.0 3.2726608387047587 5.133028716349119 22.777001872752866 -7.605333802200384 0.23318873468034856 1.4033858954936842e-15 7.266609727935845 0.9998574256225596 0.020180532461885888 0.1369452594756291 0.02781199490614896 0.2338241809324532 0.48337678649693827 2.481225282676504e-08 7.605333802200384 7.266609727935843 NIILEEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIILEEGK 8 0 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 59265600.0 19726000.0 7619600.0 31920000.0 False True 19099808.92746648 10662146.015689077 23559194.420526158 1.0 0.5582331245396062 1.2334780159317122 24.18705486997123 -6.73016551138683 1.7224187962444095 0.7342005743325966 1.2331045321465435 0.5601353791308953 0.1857057844612839 0.3359227538250484 1.9524510770499566 0.08543428181888528 0.2119764757605121 1.8613776229177104e-07 6.73016551138683 0.4989039578139469 NIILEEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIILEEGK 8 0 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 63822200.0 5482200.0 27900000.0 30440000.0 False True 7509117.4908844 26667285.747037876 23250698.931478757 1.0 3.5513208815030923 3.0963290905627265 22.840211934275757 -10.621338995944171 8.612666164507143 0.9987267243503604 3.3238249860329074 0.9720519802564114 0.18574962082649568 0.004540991130399762 0.00019964750050153598 0.17983495804812416 0.059950432335446655 2.391448342002938e-11 10.621338995944171 2.3250982616825473 NIILEEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIILEEGK 8 0 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PS23;E9PLJ3 P23528 CFL1 Cofilin-1 0 26573600.0 19726000.0 3912200.0 2935400.0 False True 16403043.009970022 3891124.2020890974 3549178.568243878 1.0 0.23721965489720487 0.21637317942083262 23.967460145405507 NIIVQFGVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIIVQFGVR 9 0 A5YKK6-2;A5YKK6;A5YKK6-3;A5YKK6-4 A5YKK6-2 CNOT1 CCR4-NOT transcription complex subunit 1 0 16461200.0 5471200.0 10990000.0 0.0 False True 8300210.398297636 9028748.63473808 0.0 1.0 1.0877734661509142 0.0 22.98471647647451 -6.966748116978145 1.1750859908333287 1.0539249878461237 1.0331684642422718e-20 0.9767311562005103 0.07526323895244477 0.10127014718529548 0.27662351478116654 0.053537356505870236 0.10040495884812553 1.0795726735089094e-07 6.966748116978145 -1.0539249878461237 down NIIVQFGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIIVQFGVR 9 0 A5YKK6-2;A5YKK6;A5YKK6-3;A5YKK6-4 A5YKK6-2 CNOT1 CCR4-NOT transcription complex subunit 1 0 20080500.0 5471200.0 8325000.0 6284300.0 False True 7082576.253475421 7861706.431736855 5140621.882363226 1.0 1.1100066064066891 0.7258124301649026 22.75584279856696 -6.830165570370487 1.327218365049441 1.0587726665385644 0.7154423897695404 0.9061984782837504 0.049477954252701246 0.18060555888469573 0.6221455201811777 0.02927028752842768 0.06735718318814998 1.4785446005591203e-07 6.830165570370487 -0.34333027676902395 NILAVSFAPLVQPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NILAVSFAPLVQPSK 15 0 Q96MG8;H0YBU4;F5H1M8;Q96MG8-2 Q96MG8 PCMTD1 Protein-L-isoaspartate O-methyltransferase domain-containing protein 1 0 1900530.0 0.0 667530.0 1233000.0 False True 0.0 638036.3173734826 941790.7944321065 0.0 NILDSKPTANKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NILDSKPTANKK 12 2 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;H0YHL7 Q9ULV4 CORO1C Coronin-1C;Coronin 0 3040060.0 150460.0 1760900.0 1128700.0 False True 197254.51705671247 1498180.5839344384 1011912.9512549154 1.0 7.595164898067697 5.1299862043918685 17.589698812245647 -10.354231926076832 8.318531246367792 0.9999772211644701 6.362575551229783 0.8631900586613024 1.006404987381096 0.00042516090508456627 3.300510082425006e-05 0.974451376109339 0.32481581297225587 4.4235208020250525e-11 10.354231926076832 5.362598330065313 NILDSKPTANKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NILDSKPTANKK 12 2 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;H0YHL7 Q9ULV4 CORO1C Coronin-1C;Coronin 0 2547560.0 150460.0 1287900.0 1109200.0 False True 206089.1280286139 1230996.319484232 847229.8046910716 1.0 5.9731259540935975 4.11098738102012 17.65290887376854 -9.817225856582928 7.406162912994532 0.9999999929728511 5.042056667556874 0.8626809832300537 0.7602148890641216 8.491158226334052e-08 1.7771746422125193e-08 0.7360749012210298 0.24535830040701323 1.5232603701239462e-10 9.817225856582928 4.042056674584023 NILFVITK(ub)PDVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NILFVITKPDVYK 13 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 1 27457000.0 11437900.0 14011600.0 2007500.0 True False 14995197.664781168 11921123.896789039 1799783.1572997598 1.0 0.7949961156422681 0.12002397017592265 23.837997203965372 -7.1329822038417685 0.6635738164459116 1.0000045351212492 4.679678781762978e-27 0.9977406309647489 0.017869444453488145 0.08035762559638822 0.05905621278675342 0.017092651013026552 0.05168415719792623 7.362372657952377e-08 7.1329822038417685 -1.0000045351212492 down NILFVITK(ub)PDVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NILFVITKPDVYK 13 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 1 65177700.0 34862000.0 25047000.0 5268700.0 True False 33755324.892494015 35048397.71837946 3888669.412388041 1.0 1.038307225008312 0.11520165854640442 25.008611769042574 -6.89721945610801 0.9786971005225895 1.0413620572477007 0.023602526239527386 0.9851308523075805 0.05199653486475979 0.1134804757835038 0.1891956430214233 0.040046322957172566 0.1028115559633443 1.2670114624443938e-07 6.89721945610801 -1.0177595310081733 down NILFVITK(ub)PDVYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NILFVITKPDVYK 13 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 1 65952200.0 30964000.0 26400000.0 8588200.0 True False 46974651.77162014 21688713.735858556 6890738.505658211 1.0 0.46171100621041433 0.14669057131406493 25.485379131035817 -8.542867166991527 0.30888229121601196 1.1731213714972473 5.053005443571561e-21 0.9986248865311877 0.0130647110239641 0.19134216741345497 0.08778465431354658 0.12483424587765656 0.09528069247684795 2.8650541393757913e-09 8.542867166991527 -1.1731213714972473 NILFVITK(ub)PDVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NILFVITKPDVYK 13 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 1 25809300.0 11437900.0 12566300.0 1805100.0 True False 15666800.727625187 12011079.314802933 1378772.5572014565 1.0 0.7666580767587003 0.08800600589565642 23.901207265488264 -7.220986836199556 0.6776782606720949 0.9972812876159801 3.2188198595632928e-25 0.996146012144497 0.024014713899717374 0.09056300084731066 0.07503985384944115 0.022032583425724332 0.05806148492444869 6.011919597987326e-08 7.220986836199556 -0.9972812876159801 down NILFVITK(ub)PDVYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NILFVITKPDVYK 13 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 1 67659400.0 34862000.0 30028000.0 2769400.0 True False 28989297.648462713 29866233.203908697 3348468.7357411594 1.0 1.0302503208625506 0.1155070666542598 24.78901704447685 -6.899253016672699 0.965995340411219 1.0388152326447486 0.02093854647850684 0.9861904624295497 0.049856932728276036 0.11195670540320345 0.1805447637280935 0.038763696405507 0.10048193866483897 1.2610926175344806e-07 6.899253016672699 -1.0178766861662418 down NILFVITK(ub)PDVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NILFVITKPDVYK 13 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 1 68731800.0 30964000.0 35835000.0 1932800.0 True False 40083508.39168976 33840750.74850329 1581050.232202735 1.0 0.8442562067625612 0.0394439083713172 25.256505453128266 -7.147903088071667 0.8395622173145182 0.9952870303037835 1.440368528229518e-19 0.9934105587087128 0.034169239400238464 0.08479367896208274 0.10869600011190904 0.029714871149282736 0.06120711162956708 7.113722372078618e-08 7.147903088071667 -0.9952870303037835 down NILFVITKPDVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NILFVITKPDVYK 13 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 0 446095000.0 115704000.0 162412000.0 167979000.0 False True 151689064.4791297 138180762.6770175 150598144.44834682 1.0 0.9109474249281118 0.9928081827485133 27.176541842110364 -10.269629690144418 5.272307890655249 1.000006785888197 0.9518778040057848 0.3154264934173868 0.03341951443627651 2.6660810133678654e-06 3.6930598428123813e-07 0.03236286848923973 0.0107861019041667 5.374899025258801e-11 10.269629690144418 -0.0481289818824121 NILFVITKPDVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NILFVITKPDVYK 13 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 0 523618000.0 192574000.0 134562000.0 196482000.0 False True 186460843.77967814 188293308.33155972 145017469.86634764 1.0 1.009827610530642 0.7777368530934038 27.474297459735553 -6.897013574801961 0.9799733378701109 1.0104559834534506 0.7548016293126761 0.9850204655055114 0.013116310615003042 0.11363639698300379 0.1900848052635107 0.010092205353436183 0.025885532247312503 1.267612243309515e-07 6.897013574801961 -0.2556543541407744 NILFVITKPDVYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NILFVITKPDVYK 13 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 0 785433000.0 185093000.0 296550000.0 303790000.0 False True 280799613.11085385 243628335.54427457 243745773.34411278 1.0 0.867623472999926 0.8680416993590622 28.064965706979844 -10.00354276691734 6.084150004081846 1.0000001143725072 0.8678325874336491 0.9999924815500055 0.00017074019618217975 2.6497244627945743e-10 4.332376002381252e-11 0.00016531862695330353 5.51061613580861e-05 9.918756600034107e-11 10.00354276691734 -0.13216752693885814 NILFVITKPDVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NILFVITKPDVYK 13 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 0 444997000.0 115704000.0 132125000.0 197168000.0 False True 158482895.58303028 126287280.62105279 150600979.2024246 1.0 0.7968511690581146 0.950266453981614 27.239751903633255 -10.266635671972136 5.70802008517794 1.0000082381547946 0.8735588115685239 0.47525512869196473 0.06263152780105104 6.5665447466885015e-06 8.436742940985505e-07 0.06064666629084359 0.020214238676748927 5.412081500690245e-11 10.266635671972136 -0.12644942658627067 NILFVITKPDVYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NILFVITKPDVYK 13 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 0 390796000.0 192574000.0 88446000.0 109776000.0 False True 160133813.47470182 87969523.84284356 132729654.05312388 1.0 0.5493500837456864 0.828867127891716 27.25470273516983 -10.428010983793257 5.979492546507174 1.000118142087786 0.6891086058187015 0.6225633850624801 0.11411235542812909 0.0001797906975544464 1.7198828819254406e-05 0.11053050505667689 0.036829604347470395 3.7324071800107745e-11 10.428010983793257 -0.31100953626908456 NILFVITKPDVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NILFVITKPDVYK 13 1 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 0 726447000.0 185093000.0 307570000.0 233784000.0 False True 239606537.228492 290453459.1242409 191237710.82640925 1.0 1.212210077754517 0.7981322756817875 27.836092029072294 -6.7673596542327035 1.5842738443985516 1.122122728768949 0.7960150133957967 0.7205119803915595 0.0893785021551199 0.27069511919266376 1.3404070978886047 0.04447711069679118 0.1061448413379032 1.7085997786634872e-07 6.7673596542327035 -0.3261077153731523 NILHACVSVCFPTSNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NILHACVSVCFPTSNK 16 0 O95071;E7EMW7;O95071-2;H0YAV7;H0YBB4 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 0 78286000.0 25203000.0 21279000.0 31804000.0 False True 38234793.58610455 17481596.196414147 25517925.459811635 1.0 0.4572169627919054 0.6674006334660969 25.188382749797785 -10.179079016169943 5.375253623248507 1.000016924245797 0.562308798128904 0.8525503883921686 0.08580712423650423 1.7404090041101553e-05 2.658088976769429e-06 0.08308559980691126 0.027694130262777634 6.620960300274523e-11 10.179079016169943 -0.437708126116893 NILHACVSVCFPTSNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NILHACVSVCFPTSNK 16 0 O95071;E7EMW7;O95071-2;H0YAV7;H0YBB4 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 0 56950000.0 25203000.0 15444000.0 16303000.0 False True 32625780.32540228 14584527.823632924 13336021.282906257 1.0 0.447024643645917 0.40875715921261485 24.959509071890235 -13.999999999999998 0.37929137817471326 9.167581024768412 0.4053533428176658 0.9998063746967698 0.003759071351165649 23.945600944837995 0.2007747786183494 159.64884680619718 0.010394128622296554 1.0000000000000041e-14 13.999999999999998 -8.762227681950746 NILK(ub)QGIETPEDQNDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NILKQGIETPEDQNDLR 17 1 Q15637-6;Q15637-2;Q15637-4;Q15637-3;Q15637;Q15637-5;Q15637-7 Q15637-6 SF1 Splicing factor 1 1 13802300.0 3684800.0 5710800.0 4406700.0 True False 4830808.48365396 4858770.900524049 3950736.9560512346 1.0 1.0057883513628632 0.8178210685477122 22.203833227898443 -6.8997960165056345 0.9625718278709608 1.0078587928299163 0.7981733320463545 0.9864641080572447 0.010154058928705115 0.11155507391375886 0.17827454076239366 0.007914877567820552 0.020571824458188746 1.2595168545430478e-07 6.8997960165056345 -0.20968546078356176 NILK(ub)QGIETPEDQNDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NILKQGIETPEDQNDLR 17 1 Q15637-6;Q15637-2;Q15637-4;Q15637-3;Q15637;Q15637-5;Q15637-7 Q15637-6 SF1 Splicing factor 1 1 27150700.0 7749700.0 9997500.0 9403500.0 True False 7503690.015471308 13989553.886273747 6940441.251046926 1.0 1.86435658421786 0.9249370958471018 22.839168799312382 -6.6648171694593605 1.9559580350298487 1.5541526883358878 0.928821886836963 0.25626913910501714 0.36760337078153765 0.47308894167689947 3.4842402290992793 0.15158305714966722 0.40771743680154426 2.1636291828666926e-07 6.6648171694593605 -0.6253308014989248 NILK(ub)QGIETPEDQNDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NILKQGIETPEDQNDLR 17 1 Q15637-6;Q15637-2;Q15637-4;Q15637-3;Q15637;Q15637-5;Q15637-7 Q15637-6 SF1 Splicing factor 1 1 14070300.0 3684800.0 4995500.0 5390000.0 True False 5047170.137975789 4774782.292090591 4116993.010534511 1.0 0.9460315704763539 0.8157032352758504 22.267043289421334 -6.956200200817097 0.48604440985236613 1.002957079810006 0.7532882250628526 0.9996022425016786 0.0015428781534375414 0.08108761699141942 0.026368028950881875 0.0018607085549340776 0.010749375947422089 1.1061137707526624e-07 6.956200200817097 -0.2496688547471534 NILK(ub)QGIETPEDQNDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NILKQGIETPEDQNDLR 17 1 Q15637-6;Q15637-2;Q15637-4;Q15637-3;Q15637;Q15637-5;Q15637-7 Q15637-6 SF1 Splicing factor 1 1 24594300.0 7749700.0 12036000.0 4808600.0 True False 6444218.919921156 11971159.67904106 5814056.0275456505 1.0 1.8576587524105288 0.9022126808219583 22.61957407474666 -6.670129841120539 1.9370743508727095 1.5473798761521074 0.9060847426345583 0.2795885324067833 0.36430378749001574 0.46079683714455616 3.333580626510771 0.15140541915920142 0.4044250189301035 2.1373229980269964e-07 6.670129841120539 -0.6412951335175491 NILK(ub)QGIETPEDQNDLRK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NILKQGIETPEDQNDLRK 18 2 Q15637-6;Q15637-2;Q15637-4;Q15637-3;Q15637;Q15637-5;Q15637-7 Q15637-6 SF1 Splicing factor 1 1 5889900.0 2393000.0 1646200.0 1850700.0 True False 2317035.524861976 2303536.244819591 1365946.1501900917 1.0 0.9941739002714732 0.5895231797412601 21.14384873314249 -6.910035013615594 0.8954982169950492 1.012514912110559 0.5371900174724138 0.990934731433279 0.018294178305816533 0.10439481926600894 0.13864240052151097 0.014980282285566169 0.04136229714423141 1.2301695882917178e-07 6.910035013615594 -0.4753248946381452 NILK(ub)QGIETPEDQNDLRK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NILKQGIETPEDQNDLRK 18 2 Q15637-6;Q15637-2;Q15637-4;Q15637-3;Q15637;Q15637-5;Q15637-7 Q15637-6 SF1 Splicing factor 1 1 14990800.0 4312800.0 5306900.0 5371100.0 True False 6542832.907913807 4359842.232001053 4309499.730763239 1.0 0.666353901033856 0.6586596037858057 22.641483996679618 NILK(ub)QGIETPEDQNDLRK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NILKQGIETPEDQNDLRK 18 2 Q15637-6;Q15637-2;Q15637-4;Q15637-3;Q15637;Q15637-5;Q15637-7 Q15637-6 SF1 Splicing factor 1 1 6648000.0 2393000.0 2913400.0 1341600.0 True False 1989885.5278748004 2897704.9359353785 1622122.357142465 1.0 1.4562169005923322 0.8151837552559584 20.924254008576767 -6.715581512668941 1.7751845237405022 1.2788564324978877 0.8164195395870443 0.4916177208270114 0.1920887018370641 0.36396601510572435 2.239028409390399 0.08600025741223953 0.21702531857375817 1.9249457183846157e-07 6.715581512668941 -0.46243689291084344 NILK(ub)QGIETPEDQNDLRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NILKQGIETPEDQNDLRK 18 2 Q15637-6;Q15637-2;Q15637-4;Q15637-3;Q15637;Q15637-5;Q15637-7 Q15637-6 SF1 Splicing factor 1 1 12978800.0 4312800.0 8666000.0 0.0 True False 5583004.617997657 8183729.481973757 0.0 1.0 1.4658288935660686 0.0 22.412610318772067 -6.844074610097716 1.419783028946451 1.2491130865145674 4.334667561711511e-22 0.8864155954165945 0.20609745634861887 0.18033040920550453 0.7301110720808808 0.11653729992895727 0.2480302807909705 1.4319418761132308e-07 6.844074610097716 -1.2491130865145674 down NILLTIGSYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NILLTIGSYK 10 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 7071700.0 3176400.0 1765800.0 2129500.0 False True 3075566.920673457 2470893.1485253526 1571720.066369376 1.0 0.8033943699668551 0.5110342603194654 21.552420936933185 -6.965401316371198 0.35110124369136364 1.0278975040271459 0.2766492221639083 0.9999211747730474 0.0017835750668217902 0.07782508975514744 0.014381554080294139 0.004001999252405893 0.025110899417067546 1.0829257576337e-07 6.965401316371198 -0.7512482818632376 NILLTIGSYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NILLTIGSYK 10 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 27909600.0 7215900.0 11559000.0 9134700.0 False True 10947047.852952892 9496206.139120791 7329222.541118759 1.0 0.867467308691745 0.669515895022031 23.3840385274505 -6.965328126108582 0.35237530804398365 1.0186143214972319 0.5116648533229439 0.9999197488919903 0.001216503636630312 0.07784978451621646 0.014468310909346077 0.0027012215121157805 0.01698800485268227 1.0831082750336631e-07 6.965328126108582 -0.506949468174288 NILLTIGSYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NILLTIGSYK 10 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 13183700.0 2575700.0 0.0 10608000.0 False True 3528005.895675272 0.0 8102608.87861782 1.0 0.0 2.2966540074522617 21.750421541119373 -6.788354663465144 1.5028065884613557 0.43989940872775346 2.320015407523973 0.7959715745959329 0.42468761386056714 0.23781708543127925 1.061056347351242 0.22245314878484423 0.52146931796166 1.627966022898136e-07 6.788354663465144 1.8801159987962195 NILLTIGSYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NILLTIGSYK 10 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 9025400.0 3176400.0 1836100.0 4012900.0 False True 2641317.3383792387 1826208.5648626857 4851978.836446776 1.0 0.6914006652389906 1.8369541463064185 21.33282621236746 -6.834974194301489 1.3054042708224838 0.8355785860077486 1.871063038364084 0.9154829856111463 0.14069803582832016 0.17475240430466157 0.5805991099613013 0.0845749785126621 0.19467285554596991 1.4622640593377334e-07 6.834974194301489 1.0354844523563353 NILLTIGSYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NILLTIGSYK 10 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 17366400.0 7215900.0 5944100.0 4206400.0 False True 9341124.796653979 5613305.609716158 3440878.3613087684 1.0 0.6009239499430371 0.36835803355729735 23.15516484954295 -9.165843786323116 0.15424331826492688 1.5208117748935868 1.59136110912253e-10 0.9998090470528749 0.003604380693746751 0.6111527554910063 0.05351482533338471 0.3187217054506969 0.17287675009384 6.825841722978699e-10 9.165843786323116 -1.5208117747344507 NINDAWVCTNDMFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NINDAWVCTNDMFR 14 0 P61970 P61970 NUTF2 Nuclear transport factor 2 0 22804600.0 3626700.0 7418900.0 11759000.0 False True 4754638.821012754 6312029.038645702 10542291.480292847 1.0 1.3275517397347163 2.2172644184248056 22.18090432241328 -6.953660481754505 0.5170988672605971 0.9845353330038893 2.5997894358084253 0.9994581180796296 0.011972236439359917 0.08204832927377428 0.030130585403718546 0.013626516946296931 0.07347074100936571 1.1126011852195291e-07 6.953660481754505 1.615254102804536 up NINDAWVCTNDMFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NINDAWVCTNDMFR 14 0 P61970 P61970 NUTF2 Nuclear transport factor 2 0 23610700.0 3626700.0 10530000.0 9454000.0 False True 4967588.99788232 10064749.781946536 7221159.911241797 1.0 2.0260834352916746 1.4536548644262182 22.24411438393617 -10.533265210558776 4.990951754057246 0.9965349931217606 1.7398691498589658 0.6901568828963112 0.23369298546856385 0.009037960947562753 0.0008451947426258682 0.22696918481723982 0.07542408673709342 2.929103983406227e-11 10.533265210558776 0.7433341567372052 NINSINFDNPVYQK(ub)TTEDEVHICHNQDGYSYPSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NINSINFDNPVYQKTTEDEVHICHNQDGYSYPSR 34 1 J3KMZ9;P01130-2;P01130-3;P01130-6;P01130-4;P01130 J3KMZ9 LDLR Low-density lipoprotein receptor 1 8504000.0 2101600.0 2580300.0 3822100.0 True False 2755217.9519233527 2195329.297930622 3426625.756172064 1.0 0.7967897045669706 1.2436859137695504 21.39373501723923 -6.7831161520093 1.5240926891527844 0.8854009191551699 1.2475545838195508 0.7781331465016254 0.08605382933346284 0.24576948440773833 1.127834141663049 0.044465525910707106 0.10463402618927943 1.6477216496240228e-07 6.7831161520093 0.3621536646643808 NINSINFDNPVYQK(ub)TTEDEVHICHNQDGYSYPSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NINSINFDNPVYQKTTEDEVHICHNQDGYSYPSR 34 1 J3KMZ9;P01130-2;P01130-3;P01130-6;P01130-4;P01130 J3KMZ9 LDLR Low-density lipoprotein receptor 1 12292300.0 3915500.0 2415400.0 5961400.0 True False 3255911.73606092 2402387.7607806404 7207901.177600683 1.0 0.7378540806782148 2.21378887448619 21.6346301596921 -6.861008061880734 1.1807086665755124 0.8573855603600604 2.2866232805709243 0.9548499498280022 0.1366161202689737 0.1457621049039492 0.38556474719550043 0.09021197825750839 0.21081535902243884 1.377183903762693e-07 6.861008061880734 1.429237720210864 up NIPGITLLNVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIPGITLLNVSK 12 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 310874000.0 81661000.0 92643000.0 136570000.0 False True 107058361.80624901 78821025.51958564 122439046.47194433 1.0 0.7362435235300308 1.1436663554924447 26.673822241093074 -6.731945457694853 1.715973633934749 0.8416141097160424 1.1435169663576241 0.5682570280240989 0.11086173697602746 0.3326417780011077 1.9197401755220331 0.05117709155716358 0.1267216477647306 1.8537644199160621e-07 6.731945457694853 0.3019028566415817 NIPGITLLNVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIPGITLLNVSK 12 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 321880000.0 146100000.0 51120000.0 124660000.0 False True 141462135.4710969 71532482.58727828 92007806.28016268 1.0 0.5056652251788859 0.650405891115375 27.075840704182216 -10.677632053834467 10.108561733794877 1.0002325945693364 0.5780355581471417 0.9189106233182411 0.059090129429172744 0.00030990782098105245 9.883132500985832e-06 0.05724362981825773 0.01907125726703557 2.1007189164272848e-11 10.677632053834467 -0.42219703642219475 NIPGITLLNVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIPGITLLNVSK 12 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 148703000.0 34604000.0 87216000.0 26883000.0 False True 52496797.89126547 71651623.37828176 21569563.266762532 1.0 1.3648760735214922 0.4108738843736472 25.645726090661153 -6.8030100923789885 1.4434062151806557 1.2005493730785768 0.3966704219962877 0.8409005795574278 0.15677293951089077 0.21646582602635944 0.8899950528919528 0.08543099181978141 0.19834463546860245 1.573946287793759e-07 6.8030100923789885 -0.803878951082289 down NIPGITLLNVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIPGITLLNVSK 12 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 263970000.0 81661000.0 83548000.0 98761000.0 False True 111853278.50554745 79856573.1037104 75435685.84664169 1.0 0.7139403884326005 0.6744164038329945 26.737032302615965 -13.999999999999998 0.27887114106831445 3.316923029801038 0.6623850020897678 0.9996026809663267 0.0028915721073892787 15.337451763475663 0.1672685016748625 20.253441525702478 0.015718809858874156 1.0000000000000041e-14 13.999999999999998 -2.6545380277112702 NIPGITLLNVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIPGITLLNVSK 12 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 241501000.0 146100000.0 42761000.0 52640000.0 False True 121488623.32741685 42530638.00560602 63646780.62013965 1.0 0.3500791830604928 0.5238908704118652 26.856245979616492 -10.725869145256649 10.397948000207833 1.000794550622241 0.43698502673710843 0.9332892832723636 0.07095832422383723 0.0013083681416548184 3.449374292396988e-05 0.06877716180644748 0.022901700666142322 1.8798831481330385e-11 10.725869145256649 -0.5638095238851326 NIPGITLLNVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIPGITLLNVSK 12 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 108848000.0 34604000.0 41598000.0 32646000.0 False True 44795560.14681672 39283034.73241915 26704762.97624712 1.0 0.8769403620285054 0.5961475398169527 25.416852412753602 -6.957388457566851 0.47080454227872715 1.0073588287404578 0.45420247222686166 0.9996607172146511 0.0031131307314542756 0.08064765343970759 0.024681538923355943 0.003888309078595215 0.023174041804234678 1.1030915110194513e-07 6.957388457566851 -0.5531563565135962 NIPGITLLNVSK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIPGITLLNVSK 12 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 9458900.0 1732100.0 1650600.0 6076200.0 True False 2270799.873680262 1404336.9139884068 5447493.111026059 1.0 0.6184327074637416 2.3989313960095315 21.114769135795566 -6.850663193650304 1.2320251553853792 0.796276764988009 2.4709674978350145 0.9412451165023044 0.18553270759701007 0.1567313673365875 0.4574884993266409 0.11782262336962286 0.2727434121357041 1.4103821614224472e-07 6.850663193650304 1.6746907328470053 up NIPGITLLNVSK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIPGITLLNVSK 12 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 10097300.0 1732100.0 1432100.0 6933100.0 True False 2372504.1782424743 1368825.0866785976 5295644.571676589 1.0 0.5769537096000432 2.2320907251676774 21.177979197318457 -6.83889878716807 1.2873391640445289 0.7748882646893733 2.285403805867098 0.922559089596187 0.19538172158181205 0.17009854296241608 0.5480332752833047 0.11902315083509106 0.27415510172834795 1.4491095308494553e-07 6.83889878716807 1.5105155411777247 up NIPGITLLNVSK(ub)LNILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIPGITLLNVSKLNILK 17 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 51423000.0 13863300.0 9209700.0 28350000.0 True False 13423217.12988676 12887181.237951037 20924284.518230483 1.0 0.9600665111240553 1.558812937000223 23.6782271465616 -6.890947242026706 1.0167444858085841 0.968555433579337 1.611280140450167 0.9814982829549137 0.0371780784865585 0.11837869579301653 0.21737677305370057 0.027825652077810407 0.06961179706736598 1.285442805694919e-07 6.890947242026706 0.64272470687083 NIPGITLLNVSK(ub)LNILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIPGITLLNVSKLNILK 17 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 72279800.0 20396800.0 10271000.0 41612000.0 True False 30943436.80581907 8438059.80231072 33387369.960812513 1.0 0.27269303843857123 1.078980663018461 24.883130106226375 -6.669097926538638 1.940710987039701 0.5353953539597149 1.0756974836703523 0.2749721475997815 0.30901006952663645 0.4632074525789937 3.362610771226874 0.12822882165002256 0.3429812407419964 2.142407467644257e-07 6.669097926538638 0.5403021297106374 NIPGITLLNVSK(ub)LNILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIPGITLLNVSKLNILK 17 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 3685540.0 1401500.0 755340.0 1528700.0 True False 1919672.424113404 721966.5812246447 1167652.5445647694 1.0 0.3760884264189413 0.608256143026093 20.872428717548345 -10.20998856756545 5.449505190503371 1.000025150405855 0.4921722847224869 0.8644844013754082 0.09478207340595594 2.8963534969614726e-05 4.198689925224638e-06 0.09177688436408783 0.030590782651662495 6.166112334165195e-11 10.20998856756545 -0.5078528656833681 NIPGITLLNVSK(ub)LNILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIPGITLLNVSKLNILK 17 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 53422200.0 13863300.0 10148000.0 29410900.0 True False 11527948.198322903 10093330.709779719 35560583.20936292 1.0 0.8755530937628698 3.08472788024293 23.458632421995876 -6.893557979719402 1.001079009865943 0.8912238301627303 3.288543752972972 0.9830802085535637 0.13181351729382157 0.11630450631949985 0.20535602182677287 0.09982699616068967 0.2522838495233668 1.2777386159371177e-07 6.893557979719402 2.397319922810242 up NIPGITLLNVSK(ub)LNILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIPGITLLNVSKLNILK 17 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 51734400.0 20396800.0 8401600.0 22936000.0 True False 26404059.681036618 7934043.574400038 18761883.343233597 1.0 0.3004857461407067 0.7105681311843258 24.654256428318824 -10.59109538872727 6.298861668996164 1.001313738883576 0.5055269386635234 0.6596985756340974 0.16741543264340114 0.0030957267040163726 0.00020096557317342306 0.16247079699079717 0.05403309854383349 2.5639208334010707e-11 10.59109538872727 -0.4957868002200526 NIPGITLLNVSKLNILKLAPGGHVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIPGITLLNVSKLNILKLAPGGHVGR 26 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 17927800.0 13123100.0 1812600.0 2992100.0 False True 17204511.184281178 1542167.1454594608 2682506.194249874 1.0 0.08963737062570279 0.15591876836935264 24.036283566921036 -10.486002573821414 5.983253356088644 1.0007374501278907 0.12277806949752786 0.995736462869303 0.027059267318400877 0.00026638369944592834 2.288393498374368e-05 0.02621932290745839 0.008733340973728368 3.2658589667395775e-11 10.486002573821414 -0.8779593806303628 NIPGITLLNVSKLNILKLAPGGHVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIPGITLLNVSKLNILKLAPGGHVGR 26 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 38695500.0 8720600.0 6172600.0 23802300.0 False True 7251565.288083992 6139346.978634825 28779250.880599327 1.0 0.8466236922286557 3.968694997187756 22.78986101129493 -6.895346135272799 0.9901868235513207 0.853107811352854 4.267159562792768 0.984106343852566 0.18115915696090293 0.11491374160135545 0.19735187044279126 0.1383244613464954 0.3522002158512768 1.272488495891718e-07 6.895346135272799 3.4140517514399145 up NIPHEAFVYQK(ub)DSDPEFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIPHEAFVYQKDSDPEFR 18 1 Q9NVE7;H0YA26 Q9NVE7 PANK4 Pantothenate kinase 4 1 5528400.0 1245200.0 2734500.0 1548700.0 True False 1632469.2585339528 2326523.258997515 1388455.3801793964 1.0 1.4251559389772894 0.8505246717027344 20.638624393574776 -6.708519857704735 1.8005265815492153 1.261769904333008 0.8519348041223629 0.4580660038111851 0.17920014706182685 0.378049274037321 2.3881720647417284 0.07923098967244979 0.20164261300034855 1.9565013067165213e-07 6.708519857704735 -0.40983510021064506 NIPHEAFVYQK(ub)DSDPEFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIPHEAFVYQKDSDPEFR 18 1 Q9NVE7;H0YA26 Q9NVE7 PANK4 Pantothenate kinase 4 1 14664400.0 1245200.0 5530700.0 7888500.0 True False 1705584.090264723 5286335.38642087 6025398.768757237 1.0 3.0994281763031575 3.5327479912304045 20.701834455097668 -9.942801758925272 0.38815228581121036 1.4843206792638558e-26 3.5898545068973635 0.9988163923256883 0.038052200740896755 1.2773662203096712 0.1722807135792534 1.610127317327526 0.11363107753522325 1.1407703927069891e-10 9.942801758925272 3.5898545068973635 NIPLLFLQNITGFMVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIPLLFLQNITGFMVGR 17 0 Q9HCC0-2;Q9HCC0;D6RD67 Q9HCC0-2 MCCC2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial 0 1376630000.0 522940000.0 457190000.0 396500000.0 False True 793338212.0349777 375600872.4582264 318131601.20787656 1.0 0.4734435663886393 0.4010037539876503 29.56336079880298 -13.999999999999998 0.27948833701313425 5.279309544151182 0.379086035680541 0.9996040457450782 0.00531170012002213 15.37056437570085 0.16746228864688126 37.58519524485903 0.028724910192458243 1.0000000000000041e-14 13.999999999999998 -4.900223508470641 NIPLLFLQNITGFMVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIPLLFLQNITGFMVGR 17 0 Q9HCC0-2;Q9HCC0;D6RD67 Q9HCC0-2 MCCC2 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial 0 1001910000.0 522940000.0 227690000.0 251280000.0 False True 676956138.6884851 215018851.34440404 205549618.3505296 1.0 0.3176259716929006 0.3036380152320583 29.334487120895428 NIPMLFVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIPMLFVR 8 0 P62310 P62310 LSM3 U6 snRNA-associated Sm-like protein LSm3 0 12467800.0 2761100.0 4327100.0 5379600.0 False True 3619828.8385304324 3681513.546903692 4822970.596767025 1.0 1.017040780413889 1.3323753171503658 21.78749005126213 -6.918065514433572 0.8389554012757627 0.9925454805386293 1.3810290849710725 0.9936263395788856 0.012200822535266432 0.09932336493677373 0.11161303660459916 0.010405964647628831 0.030616711298153854 1.2076316470421374e-07 6.918065514433572 0.3884836044324431 NIPMLFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIPMLFVR 8 0 P62310 P62310 LSM3 U6 snRNA-associated Sm-like protein LSm3 0 7751400.0 3534100.0 2018400.0 2198900.0 False True 3421911.929968535 2824357.645816953 1622942.1244140018 1.0 0.8253741486102254 0.47427933787557325 21.706371198867256 -6.959942185014918 0.4362541261918976 1.0130553810334069 0.2729943626444226 0.9997680320732146 0.0033296530467271435 0.07972187396078356 0.021208254901221045 0.004608360723845021 0.029111881620631268 1.096624173338235e-07 6.959942185014918 -0.7400610183889842 down NIPMLFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIPMLFVR 8 0 P62310 P62310 LSM3 U6 snRNA-associated Sm-like protein LSm3 0 14342000.0 2761100.0 5631200.0 5949700.0 False True 3781953.2859218786 5382394.964111808 4544503.397917847 1.0 1.4231785950787623 1.2016286438107315 21.85070011278502 -10.052254495979952 4.175972649529333 0.999966567536714 1.3124036193167896 0.7261105881870153 0.09044738920254965 63156929.39396613 130527728.85307673 30583.550469426573 0.03310035405395063 8.866362921053272e-11 10.052254495979952 0.31243705178007564 NIPMLFVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIPMLFVR 8 0 P62310 P62310 LSM3 U6 snRNA-associated Sm-like protein LSm3 0 8237200.0 3534100.0 1944100.0 2759000.0 False True 2938760.737176067 1933626.7474263618 3335894.1438253233 1.0 0.6579735202548115 1.1351363524173363 21.486776474301532 -6.714302992472567 1.7798335584400073 0.7906611883054477 1.1341654968528956 0.48553224605216827 0.14403507092632228 0.36648871138631123 2.2656422511757164 0.06433696854778072 0.16260097487556435 1.9306209185761188e-07 6.714302992472567 0.34350430854744785 NIPMTLELLQSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIPMTLELLQSTR 13 0 A0A1W2PPZ5;P23193;E5RJ93;E5RIS7 A0A1W2PPZ5 TCEA1 Transcription elongation factor A protein 1 0 9029600.0 1544500.0 4069300.0 3415800.0 False True 2024854.456959275 3462176.3020071643 3062365.782667258 1.0 1.7098395838317764 1.5123880988789753 20.949386782620596 -10.27796457008501 6.416757260317335 0.9999857772961543 1.611113841355375 0.9273894099860261 0.08060923118153285 1.6402379245337205e-05 1.8457414237259477e-06 0.07805136568445563 0.026016517493054933 5.27272874797201e-11 10.27796457008501 0.6111280640592206 NIPMTLELLQSTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIPMTLELLQSTR 13 0 A0A1W2PPZ5;P23193;E5RJ93;E5RIS7 A0A1W2PPZ5 TCEA1 Transcription elongation factor A protein 1 0 8339800.0 3086700.0 1779300.0 3473800.0 False True 2988714.398074156 2489783.7689269213 2563907.5682338234 1.0 0.8330617908928563 0.8578630229392055 21.511093608806362 -10.204754600173844 7.738497368601348 1.0000001084001326 0.8454624069356944 0.9810490772198422 0.01012506058431964 1.8939184242545364e-08 1.9443953546249635e-09 0.009803554621529683 0.003267849251867587 6.24087378928286e-11 10.204754600173844 -0.15453770146443824 NIPMTLELLQSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIPMTLELLQSTR 13 0 A0A1W2PPZ5;P23193;E5RJ93;E5RIS7 A0A1W2PPZ5 TCEA1 Transcription elongation factor A protein 1 0 8452000.0 1544500.0 2624500.0 4283000.0 False True 2115543.3885430964 2508540.911939099 3271443.6111538615 1.0 1.1857667044430824 1.5463845501210896 21.012596844143488 -6.960624339886979 0.4265505294994437 0.9851404544739384 1.7607613018837538 0.9997926412071416 0.0032664218075909297 0.07947893844271943 0.020313419976268926 0.004687708033413685 0.029967178669324322 1.0949030362777502e-07 6.960624339886979 0.7756208474098154 NIPMTLELLQSTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIPMTLELLQSTR 13 0 A0A1W2PPZ5;P23193;E5RJ93;E5RIS7 A0A1W2PPZ5 TCEA1 Transcription elongation factor A protein 1 0 6668000.0 3086700.0 1698800.0 1882500.0 False True 2566727.8139954624 1689648.2272146002 2276122.0463034366 1.0 0.658288821277248 0.8867796709462317 21.29149888424064 -9.983001040258301 5.102793224106663 1.0000012601200965 0.7725342461125051 0.5692248172214884 0.09328099877114016 128358928.81905273 39.68458633390742 2217.2522512220644 0.03193256700738722 1.03991767492868e-10 9.983001040258301 -0.2274670140075914 NIQACK(ub)ELAQTTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIQACKELAQTTR 13 1 P50990;P50990-2;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 8933500.0 2406600.0 3136600.0 3390300.0 True False 3155075.9055475537 2668631.506371038 3039504.278053987 1.0 0.8458216493868806 0.9633696205880949 21.589243283641263 -10.187916680426751 5.083582825392255 1.0000071002630286 0.904595635111537 0.4676048664246304 0.047988758290684934 3.862051877843119e-06 6.16939130984467e-07 0.04646837308573604 0.015488305138707517 6.487588862662857e-11 10.187916680426751 -0.09541146515149168 NIQACK(ub)ELAQTTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIQACKELAQTTR 13 1 P50990;P50990-2;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 6944000.0 0.0 2507000.0 4437000.0 True False 0.0 3508058.173832289 3274816.592853208 0.0 NIQACK(ub)ELAQTTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIQACKELAQTTR 13 1 P50990;P50990-2;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 41951000.0 7396700.0 8164100.0 26390200.0 True False 11221334.671203416 6707152.568595549 21174165.402764417 1.0 0.5977143330202672 1.8869560549782287 23.41974094523939 -6.822866903314591 1.359455545878024 0.7837789420609911 1.9168632517197308 0.8908462311880686 0.17794017792269728 0.18978062202225482 0.6883880449927606 0.10283711306537273 0.23685763016771946 1.503602699258844e-07 6.822866903314591 1.1330843096587397 NIQACK(ub)ELAQTTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIQACKELAQTTR 13 1 P50990;P50990-2;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 8781200.0 2406600.0 1967200.0 4407400.0 True False 3296385.0559195993 1880282.5993395285 3366462.893252285 1.0 0.5704074516303685 1.0212589961863956 21.652453345164155 -10.996144794793612 12.38623916996267 1.1829083690929414 0.7958332239083211 0.21471759008458657 0.1840593723179902 0.06324321277427954 1.968437261954534e-05 0.012123419772096248 0.05940490697508054 1.0089164548961502e-11 10.996144794793612 -0.3870751451846203 NIQACK(ub)ELAQTTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIQACKELAQTTR 13 1 P50990;P50990-2;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 9322800.0 0.0 3213700.0 6109100.0 True False 0.0 3196387.1602304964 7386484.564713056 0.0 NIQACK(ub)ELAQTTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIQACKELAQTTR 13 1 P50990;P50990-2;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 27447000.0 7396700.0 5947700.0 14102600.0 True False 9575173.960754799 5616705.266551511 11536071.50489565 1.0 0.5865904149180339 1.2047897565284835 23.19086726733184 -6.726467847067044 1.7359562091675211 0.7502418965195342 1.2042019366293382 0.5428932323723987 0.17384098275757698 0.34289515495166073 2.0226742097996135 0.0794097637128996 0.19785432514196952 1.8772933983919425e-07 6.726467847067044 0.45396004010980395 NIQDTSDLDAIAK(ub)DVFQHSQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIQDTSDLDAIAKDVFQHSQSR 22 1 Q9NZB2;Q9NZB2-6;Q9NZB2-4;Q9NZB2-2;Q9NZB2-5;A0A0C4DH52 Q9NZB2 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 1 9465600.0 2464200.0 4116800.0 2884600.0 True False 2385975.319834886 5760659.708828385 2129036.723854942 1.0 2.414383611154466 0.8923129699439954 21.186147689416842 -6.662653993925148 1.9631194047689267 1.9084461452135686 0.8985943111322929 0.24692849165414 0.6018377663234069 0.47829371733705883 3.5460325322953947 0.24742404246774558 0.6675241147198671 2.1744328779469317e-07 6.662653993925148 -1.0098518340812757 NIQDTSDLDAIAK(ub)DVFQHSQSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIQDTSDLDAIAKDVFQHSQSR 22 1 Q9NZB2;Q9NZB2-6;Q9NZB2-4;Q9NZB2-2;Q9NZB2-5;A0A0C4DH52 Q9NZB2 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 1 29204300.0 9041700.0 7382600.0 12780000.0 True False 13716919.93681237 6065117.349482926 10254027.398327013 1.0 0.4421632099204611 0.7475459101287073 23.709453232402886 -10.125003500633468 5.421861049796501 1.0000073030036303 0.594854560024453 0.7012050510925494 0.12467196529775271 1.1005995578377978e-05 1.7759841015822621e-06 0.12071528683630989 0.04023770377802338 7.498881648297127e-11 10.125003500633468 -0.40515274297917725 NIQDTSDLDAIAK(ub)DVFQHSQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIQDTSDLDAIAKDVFQHSQSR 22 1 Q9NZB2;Q9NZB2-6;Q9NZB2-4;Q9NZB2-2;Q9NZB2-5;A0A0C4DH52 Q9NZB2 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 1 11890400.0 2464200.0 5603200.0 3823000.0 True False 2049091.482569613 5573014.449451881 4622371.624445171 1.0 2.7197489701451394 2.2558151569926976 20.966552964851118 -10.55418581250194 5.6729075148604675 0.9955997569673323 2.487782063568919 0.9320289349461226 0.18940018610786757 0.010536735692194928 0.0008280445463904373 0.18331904399040955 0.06112864721369607 2.7913493094342667e-11 10.55418581250194 1.492182306601587 NIQDTSDLDAIAK(ub)DVFQHSQSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIQDTSDLDAIAKDVFQHSQSR 22 1 Q9NZB2;Q9NZB2-6;Q9NZB2-4;Q9NZB2-2;Q9NZB2-5;A0A0C4DH52 Q9NZB2 FAM120A Constitutive coactivator of PPAR-gamma-like protein 1 1 29200800.0 9041700.0 11634000.0 8525100.0 True False 11704658.888552565 10986557.672892096 6973619.274912838 1.0 0.9386482577153282 0.5957985910835217 23.480579554495336 -6.937358105769137 0.683702828681875 1.0040806428832634 0.5101127780539815 0.9977969276330289 0.00834791743159222 0.08899297642845212 0.06025560300650967 0.007971747314232587 0.029868085767906838 1.1551593407905133e-07 6.937358105769137 -0.4939678648292819 NIQFEAFHVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIQFEAFHVFK 11 0 A0A087X0K1;Q9Y376 A0A087X0K1 CAB39 Calcium-binding protein 39 0 4537900.0 1282900.0 1418200.0 1836800.0 False True 1681894.323621271 1206610.0881003016 1646745.5558297373 1.0 0.7174113564414444 0.979101678804733 20.681655630697815 -10.456681085571779 8.137709601176642 1.0000057509355769 0.8482565177682182 0.3095425834722665 0.1068346267357498 1.1147321646667856e-05 7.44270040610384e-07 0.103446101266282 0.03448072751215372 3.4939679300917534e-11 10.456681085571779 -0.15174923316735867 NIQFEAFHVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIQFEAFHVFK 11 0 A0A087X0K1;Q9Y376 A0A087X0K1 CAB39 Calcium-binding protein 39 0 4125900.0 1282900.0 1492100.0 1350900.0 False True 1757222.7990689136 1426174.0882851298 1031845.2426588256 1.0 0.8116068656978533 0.5872022848813262 20.744865692220706 -6.968805166972343 0.2852868592842866 1.0463938848498902 0.34552733798992 0.9999715026271339 0.0009007521588254631 0.07669234991458397 0.010411360412106016 0.00402280161724836 0.02046360779143379 1.0744713331602625e-07 6.968805166972343 -0.7008665468599702 NIQTDNNK(ub)SIGCFGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIQTDNNKSIGCFGSR 16 1 Q99959-2;Q99959 Q99959-2 PKP2 Plakophilin-2 1 9328400.0 3932000.0 2996200.0 2400200.0 True False 5154890.077542164 2549178.639096123 2151850.328344154 1.0 0.4945165853685019 0.41743864485470267 22.29751023333354 -13.999999999999998 0.2647811669731959 4.794474975546723 0.3905311323545517 0.9995722352983845 0.005343890770483286 14.633827643507393 0.1628547769839156 29.796617238103767 0.032869649116548626 1.0000000000000041e-14 13.999999999999998 -4.403943843192171 NIQVSHQEFSK(ub)MK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIQVSHQEFSKMK 13 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 23828900.0 6989700.0 7191600.0 9647600.0 True False 6767815.799468338 10063243.383698571 7120604.138203882 1.0 1.4869263115123663 1.052127355292864 22.690258872295935 -10.280503963218408 5.896173101528736 0.9999845715830077 1.2695268334026149 0.33877689793521826 0.17750593057208772 3.600309103224633e-05 4.393170872496769e-06 0.1718792081860318 0.05728979274656154 5.24198817332943e-11 10.280503963218408 0.26954226181960717 NIQVSHQEFSKMK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIQVSHQEFSKMK 13 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 24150100.0 9360500.0 5504600.0 9285000.0 True False 14200562.84421426 4522261.122363896 7449815.680239921 1.0 0.3184564704916892 0.5246141129733602 23.759444776791092 -10.063235070183337 5.35840325214323 1.0000055298407116 0.4215352917320496 0.913025980143443 0.08416350511128007 5.5600029097877555e-06 9.72095970879335e-07 0.08149174200517093 0.027163654470902274 8.6449986505174e-11 10.063235070183337 -0.5784702381086619 NIQVSHQEFSKMK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIQVSHQEFSKMK 13 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 8672700.0 2362400.0 4182000.0 2128300.0 True False 1964440.272064952 4159470.7359379972 2573317.689852641 1.0 2.117382134283831 1.30994957008678 20.90568687328486 -10.020617260574044 4.348211034479928 0.99996368109212 1.713665851360313 0.5101967620943468 0.3296329644797789 229449226.19177768 395132752.38196325 125260.13103354922 0.12063325273630265 9.53636223961068e-11 10.020617260574044 0.7137021702681929 NISFTVWDVGGQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NISFTVWDVGGQDK 14 0 P84077;P61204;F5H423;F5H0C7 P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 0 55566000.0 16974000.0 22681000.0 15911000.0 False True 22253078.376449812 19297083.20984554 14264682.34908915 1.0 0.867164662946922 0.6410206312932104 24.407501589110367 -6.963068537116728 0.3897857417715036 1.0139221425890719 0.4861404004407147 0.9998676217266625 0.0017050448546027492 0.07862268681663338 0.01721031243581725 0.002920128388517726 0.0190245562152678 1.0887582600650141e-07 6.963068537116728 -0.5277817421483572 NISFTVWDVGGQDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NISFTVWDVGGQDK 14 0 P84077;P61204;F5H423;F5H0C7 P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 0 90587000.0 40118000.0 18873000.0 31596000.0 False True 38844476.04948294 26409087.321394827 23320059.74031779 1.0 0.6798672554561682 0.6003442989065161 25.211206116315818 -13.999999999999998 0.19558791740788795 2.7505380523559704 0.5463938302410511 0.9994872933537194 0.003911218027433568 12.44715553956185 0.1402455055731814 8.320838041267976 0.05235413711662205 1.0000000000000041e-14 13.999999999999998 -2.2041442221149192 NISFTVWDVGGQDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NISFTVWDVGGQDK 14 0 P84077;P61204;F5H423;F5H0C7 P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 0 141726000.0 31514000.0 64828000.0 45384000.0 False True 47809041.982006155 53258936.89652408 36413832.50748616 1.0 1.1139929747299495 0.7616515830037172 25.510780160847645 -6.819615039851075 1.3736124635263014 1.0614648661258566 0.7540273892989136 0.8834815515754743 0.050109453095701355 0.19398127206924343 0.7192978964417053 0.02866830186849791 0.0660803193422167 1.514903469211471e-07 6.819615039851075 -0.307437476826943 NISFTVWDVGGQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NISFTVWDVGGQDK 14 0 P84077;P61204;F5H423;F5H0C7 P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 0 72397000.0 16974000.0 23641000.0 31782000.0 False True 23249746.505102307 22596462.449667435 24275746.17083631 1.0 0.9719014546979468 1.0441294990252405 24.47071165063326 -6.801210587083212 1.4510101222991716 0.9845206089982119 1.0451561266042628 0.83567121398129 0.012051017450154071 0.2190314478792238 0.9103120655238266 0.0065334080485007304 0.01518292081281894 1.5804814863743554e-07 6.801210587083212 0.060635517606050904 NISFTVWDVGGQDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NISFTVWDVGGQDK 14 0 P84077;P61204;F5H423;F5H0C7 P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 0 78672000.0 40118000.0 16501000.0 22053000.0 False True 33359894.52874266 16412105.83780793 26664180.338448692 1.0 0.4919711548748264 0.799288508405655 24.991611391750094 -10.32888082207549 6.038073407755892 1.0000314188506076 0.6456298316402431 0.6393638802611155 0.12546178420884066 5.306898703016488e-05 5.898386400209856e-06 0.12148859696105663 0.040492616735525545 4.689420503071843e-11 10.32888082207549 -0.3544015872103645 NISFTVWDVGGQDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NISFTVWDVGGQDK 14 0 P84077;P61204;F5H423;F5H0C7 P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 0 130062000.0 31514000.0 67360000.0 31188000.0 False True 40795494.23381063 63611356.78580109 25512104.0159038 1.0 1.5592740811332308 0.6253657295996132 25.281906482940094 -6.744535426344365 1.670266639038645 1.3310074069066344 0.6242771862730039 0.625063219739205 0.23497337722076164 0.30966581814946587 1.6979391989403734 0.1112212409837156 0.2715615572782575 1.8007962335896064e-07 6.744535426344365 -0.7067302206336306 NISYK(ub)YR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NISYKYR 7 1 A2ACR1;P28065-2;P28065;A0A0G2JJA7;A2ACR0;A0A0G2JJQ0;A0A0G2JJ13;A0A0G2JHI2 A2ACR1 PSMB9 Proteasome subunit beta type;Proteasome subunit beta type-9 1 10507100.0 2135900.0 2286500.0 6084700.0 True False 3240316.455206158 1878456.2104939607 4882056.37798125 1.0 0.5797138139010709 1.5066603665013454 21.62770328553969 -6.783423905253542 1.5224298444334576 0.763083714153342 1.514821172398465 0.7793594091559715 0.17801202743388608 0.24528551909015028 1.1230978223471777 0.09207228174106626 0.21664778416161487 1.646554441480369e-07 6.783423905253542 0.7517374582451231 NISYK(ub)YR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NISYKYR 7 1 A2ACR1;P28065-2;P28065;A0A0G2JJA7;A2ACR0;A0A0G2JJQ0;A0A0G2JJ13;A0A0G2JHI2 A2ACR1 PSMB9 Proteasome subunit beta type;Proteasome subunit beta type-9 1 4832110.0 783310.0 1299300.0 2749500.0 True False 651356.971516761 1292300.413009141 3324407.7377483603 1.0 1.984012560731281 5.103818463794266 19.31308889323459 -6.950201720665871 0.5566241204916692 0.9584531173460622 6.277617142253328 0.999217022409879 0.048950532179286466 0.08340483098172645 0.03562784704042322 0.05268873842768329 0.25915441398256306 1.1214974213081753e-07 6.950201720665871 5.319164024907265 NITINCVK(ub)GINAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NITINCVKGINAR 13 1 A0A499FJI4;O75592-2;O75592;H7C3U4 A0A499FJI4 MYCBP2 E3 ubiquitin-protein ligase MYCBP2 1 10684100.0 3349500.0 5083700.0 2250900.0 True False 4391226.936604144 4325231.7761074 2017998.4601574244 1.0 0.9849711341614742 0.45955230492323357 22.06619266353659 -6.913018142739375 0.8749213415317454 1.0147567364011285 0.38707563428398106 0.9920116915821595 0.022460708154645515 0.10245624292520591 0.1281888962090583 0.018667789440955988 0.05267618703188239 1.221748620304312e-07 6.913018142739375 -0.6276811021171474 down NITINCVK(ub)GINAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NITINCVKGINAR 13 1 A0A499FJI4;O75592-2;O75592;H7C3U4 A0A499FJI4 MYCBP2 E3 ubiquitin-protein ligase MYCBP2 1 9184600.0 3349500.0 3287900.0 2547200.0 True False 4587900.666833998 3142629.7063686624 1945603.8212307063 1.0 0.6849820723205233 0.424072786774898 22.12940272505948 -7.3361184567161795 0.19281101420322422 1.196423547420902 1.6463078872217644e-11 0.9999782767219503 0.001097454705738833 0.11228214708004672 0.012808930077341565 0.02193430058372396 0.050380110512988685 4.611917642740423e-08 7.3361184567161795 -1.196423547404439 down NITLNFGPQHPAAHGVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NITLNFGPQHPAAHGVLR 18 0 O75306-2;O75306 O75306-2 NDUFS2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial 0 12055800.0 4082400.0 3660400.0 4313000.0 False True 5352065.934017835 3114282.588127451 3866732.133217371 1.0 0.5818841969664481 0.722474681905607 22.351664458490138 -10.385872960303457 5.128703007323639 1.0002464223275416 0.6521794394360039 0.890840267225739 0.057395825131979564 0.00016183535946922743 1.937868738185775e-05 0.05561216483482477 0.01852442290648731 4.1127000809461407e-11 10.385872960303457 -0.3480669828915377 NITLNFGPQHPAAHGVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NITLNFGPQHPAAHGVLR 18 0 O75306-2;O75306 O75306-2 NDUFS2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial 0 24891800.0 4082400.0 5909400.0 14900000.0 False True 5591773.602711776 5648303.168227431 11380926.875132518 1.0 1.010109415997858 2.0352982226628855 22.41487452001303 -6.909056518744309 0.9021247569162982 0.9673027991439541 2.1651521224067025 0.9905608221073029 0.04718635118978601 0.10504572676966138 0.14217200611140496 0.0384527107939664 0.10546714442939434 1.2329443683716627e-07 6.909056518744309 1.1978493232627483 up NITLNFGPQHPAAHGVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NITLNFGPQHPAAHGVLR 18 0 O75306-2;O75306 O75306-2 NDUFS2 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial 0 5556800.0 3460900.0 2095900.0 0.0 False True 2877891.69386623 2084608.9706964216 0.0 1.0 0.7243528222898156 0.0 21.456580868260534 -7.38131121093156 0.7708949087214645 0.9899923626374727 3.911098378716795e-18 0.9875843612009889 0.04699092124930895 0.11164300543965235 0.13852673973297902 0.04056031720882923 0.07249562081929398 4.156126800141717e-08 7.38131121093156 -0.9899923626374727 down NITLPHLESQSLSIQWVYNILDKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NITLPHLESQSLSIQWVYNILDKK 24 1 Q96C86;A0A3B3ITF0 Q96C86 DCPS m7GpppX diphosphatase 0 73037000.0 36352000.0 17495000.0 19190000.0 False True 47058380.60504803 16521387.870659031 15697616.906027792 1.0 0.3510827966928967 0.33357749893212185 25.487948338933016 NITVIFHPLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NITVIFHPLLR 11 0 Q96A65 Q96A65 EXOC4 Exocyst complex component 4 0 9263760.0 2615260.0 4029500.0 2619000.0 False True 3428631.18621387 3428314.3068679776 2348011.003221953 1.0 0.9999075784682918 0.6848246065844101 21.709201292951132 -6.906958294303372 0.916206237018704 1.010718651712722 0.6466483033528924 0.9897220304933613 0.015060382808053423 0.10646374862522942 0.14993489711995006 0.012147624837354865 0.0328663635097822 1.2389155550127382e-07 6.906958294303372 -0.36407034835982965 NITVIFHPLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NITVIFHPLLR 11 0 Q96A65 Q96A65 EXOC4 Exocyst complex component 4 0 5800210.0 2874600.0 886810.0 2038800.0 False True 2783347.3964764876 1240917.8576530574 1504777.11731105 1.0 0.4458364986073847 0.5406357536310368 21.408389555570174 -10.008274490299897 5.420552825537263 1.0000021335611684 0.4932361261186317 0.9744254244750687 0.03870163380334386 9.97857299740434e-07 1.8264334497201333e-07 0.03747285323461914 0.012490898598891352 9.811276377762524e-11 10.008274490299897 -0.5067660074425366 NITVIFHPLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NITVIFHPLLR 11 0 Q96A65 Q96A65 EXOC4 Exocyst complex component 4 0 30997700.0 5129000.0 11780800.0 14087900.0 False True 7781067.980126585 9678424.196189472 11303420.390054088 1.0 1.2438426474243476 1.452682384850492 22.8915367533132 -6.972928176098956 0.17461194872797894 0.82655491362216 1.8755876448027844 0.999997136106859 0.0003130075724836011 0.07536351354064602 0.005473830871793463 0.008438940877564916 0.023833598431717135 1.0643190214351942e-07 6.972928176098956 1.0490327311806245 NITVIFHPLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NITVIFHPLLR 11 0 Q96A65 Q96A65 EXOC4 Exocyst complex component 4 0 14117160.0 2615260.0 3935800.0 7566100.0 False True 3582192.296744077 3761903.3420498753 5779143.008720814 1.0 1.0501678945234574 1.613297815969731 21.772411354474023 -6.924379195833995 0.7915618429465707 0.9894242821451531 1.7139339385289536 0.995313644951939 0.019033910638481914 0.09566297797405547 0.09275803044438873 0.01679231252286639 0.052615713569633876 1.1902023520330142e-07 6.924379195833995 0.7245096563838005 NITVIFHPLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NITVIFHPLLR 11 0 Q96A65 Q96A65 EXOC4 Exocyst complex component 4 0 8035770.0 2874600.0 1654670.0 3506500.0 False True 2390357.266372294 1645755.9642837192 4239692.937775822 1.0 0.688497902567254 1.7736649652418515 21.18879483100445 -6.829951937517596 1.3280537094959448 0.8335432670495897 1.8028507577034567 0.9057845099920488 0.14003270981734367 0.18087641303671817 0.6239198950294559 0.08278736116774667 0.19052455488182196 1.4792720871274586e-07 6.829951937517596 0.969307490653867 NITVIFHPLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NITVIFHPLLR 11 0 Q96A65 Q96A65 EXOC4 Exocyst complex component 4 0 20655900.0 5129000.0 11679900.0 3847000.0 False True 6639591.60770497 11029903.297542745 3146885.4735533535 1.0 1.6612321885495187 0.4739576858765716 22.66266307540565 -6.755537112050487 1.6291241244733397 1.386204075328842 0.47053051165414006 0.6725352902220021 0.2779676227901579 0.29048446404815187 1.5183637963692531 0.13468929488660064 0.32514070715884874 1.755750852462184e-07 6.755537112050487 -0.915673563674702 NITYLPAGQSVLLQLPQ ddPTM_RPMI8226_Bortezomib_1h_R1 1 NITYLPAGQSVLLQLPQ 17 0 P35232 P35232 PHB Prohibitin 0 8981700.0 2810200.0 4823400.0 1348100.0 False True 3684199.414015513 4103767.521465937 1208611.5438883223 1.0 1.1138831155160316 0.32805269424084255 21.812919721368285 -6.8701157181952155 1.1335596378017583 1.0644462458131003 0.2819443993447788 0.9647946390631067 0.06505777141474033 0.1367399693576589 0.32833540799211186 0.04453994369842851 0.10546548948507471 1.3486034979756916e-07 6.8701157181952155 -0.7825018464683215 down NITYLPAGQSVLLQLPQ ddPTM_RPMI8226_Bortezomib_2h_R1 1 NITYLPAGQSVLLQLPQ 17 0 P35232 P35232 PHB Prohibitin 0 31097900.0 9233400.0 4576600.0 17287900.0 False True 8940290.77110762 6404060.246653716 12759680.36411698 1.0 0.7163145372575295 1.4272108917701536 23.091890323239834 -6.7984024456382794 1.4623391719587562 0.8431611596880778 1.436652438856342 0.8274860980975769 0.12135934631974606 0.22303890673671029 0.941769493510299 0.06529201976204015 0.15200122679149744 1.5907339658403329e-07 6.7984024456382794 0.5934912791682642 NITYLPAGQSVLLQLPQ ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NITYLPAGQSVLLQLPQ 17 0 P35232 P35232 PHB Prohibitin 0 16912600.0 2810200.0 3417400.0 10685000.0 False True 3849206.8827994913 3266407.968169434 8161423.064482605 1.0 0.8485924679095987 2.1202869352002405 21.876129782891176 -6.877184693862512 1.0954227047449654 0.9092458461661378 2.2056687170079217 0.9713407799299981 0.09601702682593434 0.13015107087786643 0.28762858608512326 0.06768516373696651 0.16256595048796108 1.3268300722799347e-07 6.877184693862512 1.2964228708417838 up NITYLPAGQSVLLQLPQ ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NITYLPAGQSVLLQLPQ 17 0 P35232 P35232 PHB Prohibitin 0 15786700.0 9233400.0 2018300.0 4535000.0 False True 7677981.208975827 2007427.0172988158 5483247.53252913 1.0 0.26145245249520327 0.7141522469629155 22.87229559867411 -9.885605048719002 6.203815935530583 1.000000062508124 0.4878023497322867 0.6305657947694945 0.18481391718520485 1.5995284254211814e-07 2.8797608583732813e-08 0.17894532718302558 0.059648435283742994 1.301352501659909e-10 9.885605048719002 -0.5121977127758373 NIVAAMK(ub)AHGVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIVAAMKAHGVDK 13 1 P30043;M0R192;A0A2R8Y7Y9;M0QZL1 P30043 BLVRB Flavin reductase (NADPH) 1 9896700.0 4921300.0 4975400.0 0.0 True False 6451871.957936988 4233089.713957297 0.0 1.0 0.6561025608621724 0.0 22.62128637677583 -7.52077599315666 0.7070557339408052 0.993745087207486 5.713277288440255e-17 0.9870665966949889 0.04717629730984782 0.11973273887763507 0.1432004962296677 0.0418527951412093 0.07593960936205683 3.0145605179460646e-08 7.52077599315666 -0.9937450872074859 down NIVAAMK(ub)AHGVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIVAAMKAHGVDK 13 1 P30043;M0R192;A0A2R8Y7Y9;M0QZL1 P30043 BLVRB Flavin reductase (NADPH) 1 18436800.0 5819600.0 4894700.0 7722500.0 True False 5634859.983487986 6849179.235523289 5699745.579965947 1.0 1.2155012290622416 1.0115150326127176 22.425948331693775 -10.798376350289837 2.8450694709985545 0.9697254722252343 1.1135081307735024 0.2922102010192099 0.0832770172266904 62466204.77580748 39007323.03821599 12933364.564100735 0.03047626460838846 1.5908295507625353e-11 10.798376350289837 0.1437826585482681 NIVAAMK(ub)AHGVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIVAAMKAHGVDK 13 1 P30043;M0R192;A0A2R8Y7Y9;M0QZL1 P30043 BLVRB Flavin reductase (NADPH) 1 42340900.0 7983100.0 7927800.0 26430000.0 True False 12110946.342785826 6513022.149815888 21206098.91531948 1.0 0.5377797874313534 1.7509861174433654 23.529808265057273 -6.803465565696131 1.4418556817062544 0.7460838092257375 1.7691766482379678 0.8420674853453753 0.1986814202381377 0.2158478994603693 0.885539979968765 0.10838878947398396 0.25154407723058086 1.5722964516279512e-07 6.803465565696131 1.0230928390122305 NIVAAMK(ub)AHGVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIVAAMKAHGVDK 13 1 P30043;M0R192;A0A2R8Y7Y9;M0QZL1 P30043 BLVRB Flavin reductase (NADPH) 1 13151400.0 4921300.0 4684700.0 3545400.0 True False 6740837.6031318465 4477714.463768751 2708049.539805019 1.0 0.6642667762368833 0.4017378401976095 22.684496438298723 -7.58480535185274 0.19232332835550925 1.220104687853234 2.0176453314906796e-10 0.9999453504853169 0.0018100388410015773 0.13270742301741495 0.020366633070438067 0.039732146168959814 0.07357819694480598 2.6013252000745644e-08 7.58480535185274 -1.2201046876514694 down NIVAAMK(ub)AHGVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIVAAMKAHGVDK 13 1 P30043;M0R192;A0A2R8Y7Y9;M0QZL1 P30043 BLVRB Flavin reductase (NADPH) 1 16582400.0 5819600.0 7304800.0 3458000.0 True False 4839255.251993392 7265447.592510731 4181051.8120144946 1.0 1.501356554713236 0.8639866248617968 22.20635360712805 -6.696975942705676 1.8419425178347932 1.3122438384168411 0.8660034454657826 0.4031396215636238 0.21174837870622 0.4018287963976163 2.6483638514329977 0.09179291181469881 0.23692705184379614 2.0092041073127664e-07 6.696975942705676 -0.44624039295105855 NIVAAMK(ub)AHGVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIVAAMKAHGVDK 13 1 P30043;M0R192;A0A2R8Y7Y9;M0QZL1 P30043 BLVRB Flavin reductase (NADPH) 1 32270000.0 7983100.0 7584900.0 16702000.0 True False 10334280.320426889 7162793.647337041 13662407.376991978 1.0 0.6931100594570634 1.322047298251303 23.300934587149722 -6.774000114522016 1.5589447516348784 0.8248798931599866 1.3261502572686903 0.7457057386879903 0.12949172017661426 0.2600028434024589 1.2475279509440935 0.06544945143463676 0.15524490151643008 1.6826736173549514e-07 6.774000114522016 0.5012703641087037 NIVDDGK(ub)SQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIVDDGKSQK 10 1 Q9UJA5;Q9UJA5-2;Q9UJA5-3 Q9UJA5 TRMT6 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 1 846720.0 177310.0 291600.0 377810.0 True False 242866.29862258132 278716.1478077507 288579.05924119556 1.0 1.147611461073406 1.188221918305976 17.889802782511232 -13.999999993124204 0.181084901100836 0.23154438550102202 1.22012216140663 0.9994968651740137 0.0018140548788022032 12.219163608960894 0.13491095005503204 3.3046488148222766 0.03004449194442775 1.0000000158321053e-14 13.999999993124204 0.988577775905608 NIVEAAAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIVEAAAVR 9 0 P62854;Q5JNZ5 P62854 RPS26;RPS26P11 40S ribosomal protein S26;Putative 40S ribosomal protein S26-like 1 0 22679300.0 4068400.0 9341300.0 9269600.0 False True 5333711.798441646 7947614.452102207 8310470.712281881 1.0 1.4900719709723098 1.5581026921458254 22.346708441796043 -11.743924656351643 0.32641061734311344 1.0061051053026591e-09 1.572089782777702 0.9994982277920903 0.005569003547456741 4.531546186586939 0.17285383990745015 3.148732396151556 0.022072463012486464 1.8033305648180077e-12 11.743924656351643 1.5720897817715969 NIVEAAAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIVEAAAVR 9 0 P62854;Q5JNZ5 P62854 RPS26;RPS26P11 40S ribosomal protein S26;Putative 40S ribosomal protein S26-like 1 0 17595700.0 6114600.0 2411500.0 9069600.0 False True 5920495.369962826 3374424.5258063674 6693999.677832203 1.0 0.569956450422417 1.1306485791364167 22.497286461038144 -6.701768274697065 1.8243997342929432 0.7334276419203505 1.1290465160044898 0.426051963077155 0.18146825007020653 0.39185406761050806 2.5368415868376673 0.07931347301920814 0.20354168196237724 1.9871549152823145e-07 6.701768274697065 0.3956188740841393 NIVEAAAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIVEAAAVR 9 0 P62854;Q5JNZ5 P62854 RPS26;RPS26P11 40S ribosomal protein S26;Putative 40S ribosomal protein S26-like 1 0 21901500.0 4068400.0 7535100.0 10298000.0 False True 5572597.424376005 7202174.366756443 7865824.493967417 1.0 1.2924268197182591 1.4115185244784116 22.409918503318934 -12.759115176634307 0.137404192989444 1.3334234906667133e-16 1.5738056346320985 0.9996383552811634 0.0032879909516148873 7.5841417588206825 0.10426212820460619 2.211007845290195 0.13400812001818999 1.7413450004874235e-13 12.759115176634307 1.5738056346320983 NIVGVVLGCNNFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIVGVVLGCNNFR 13 0 Q99707;Q99707-2;B1ANE3 Q99707 MTR Methionine synthase 0 12920400.0 3092200.0 4414800.0 5413400.0 False True 4053904.144907395 3756129.0487556183 4853273.29699951 1.0 0.9265460934674915 1.1971850156092865 21.950880545819743 -6.834418652467787 1.308123001717943 0.9608553476340539 1.205143615297895 0.9144124527761779 0.03343067576697678 0.17542213255727326 0.5855026980549993 0.020056238161403905 0.046157713170698354 1.464135758572983e-07 6.834418652467787 0.24428826766384104 NIVGVVLGCNNFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIVGVVLGCNNFR 13 0 Q99707;Q99707-2;B1ANE3 Q99707 MTR Methionine synthase 0 19217200.0 3092200.0 5152000.0 10973000.0 False True 4235469.903562942 4924367.604614296 8381403.396028792 1.0 1.1626496508620787 1.9788603358928907 22.014090607342634 -6.939724898791686 0.6621254463108113 0.9907936454259315 2.19719098105543 0.9981275527784402 0.01853248625234459 0.08789249067843455 0.055184460046723935 0.01800252922022309 0.07033525403972503 1.1488811428498032e-07 6.939724898791686 1.2063973356294988 NIVHNYSEAEIK(ub)VR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIVHNYSEAEIKVR 14 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1;D6RFG3;D6REL6;I6L9I8;Q9H201-2;Q9H201;D6RBI9;D6RBR6 Q9Y6I3-3 EPN1;EPN3 Epsin-1;Epsin-3 1 24129600.0 4674000.0 8781600.0 10674000.0 True False 6127659.263080392 7471419.510408701 9569556.872237943 1.0 1.2192942181730904 1.5616985967048205 22.546904645775786 -6.9645823147399 0.3651552214220577 0.9721792817929849 1.8206418687225254 0.9999042673320282 0.0022615485271142216 0.07810304415296028 0.015361830853258084 0.004549188699311804 0.029157986218595132 1.0849698885385265e-07 6.9645823147399 0.8484625869295406 NIVHNYSEAEIK(ub)VR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIVHNYSEAEIKVR 14 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1;D6RFG3;D6REL6;I6L9I8;Q9H201-2;Q9H201;D6RBI9;D6RBR6 Q9Y6I3-3 EPN1;EPN3 Epsin-1;Epsin-3 1 34063700.0 5625000.0 8197700.0 20241000.0 True False 5446437.453969327 11471084.360440738 14939274.883015983 1.0 2.1061628738765172 2.742944357531975 22.376881432595752 -8.896015414817665 0.18853219521179837 5.989377431204283e-16 3.504738440812708 0.9996693291572492 0.013094618668365397 0.396044774723805 0.059667925515697086 0.6014744957413527 0.3628115299467218 1.2705290083413338e-09 8.896015414817665 3.5047384408127074 NIVHNYSEAEIK(ub)VR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIVHNYSEAEIKVR 14 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1;D6RFG3;D6REL6;I6L9I8;Q9H201-2;Q9H201;D6RBI9;D6RBR6 Q9Y6I3-3 EPN1;EPN3 Epsin-1;Epsin-3 1 77971000.0 13216000.0 64755000.0 0.0 True False 20049638.219019897 53198964.31687572 0.0 1.0 2.6533628056395067 0.0 24.25707286875533 -6.738588369096909 1.6945503752398194 1.9857530141607642 3.890626975077449e-05 0.5968317897447426 0.6947190650332354 0.3207152921298774 1.8082014479722124 0.3245662313429985 0.7968684516096732 1.8256252378659025e-07 6.738588369096909 -1.9857141078910134 NIVHNYSEAEIK(ub)VR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIVHNYSEAEIKVR 14 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1;D6RFG3;D6REL6;I6L9I8;Q9H201-2;Q9H201;D6RBI9;D6RBR6 Q9Y6I3-3 EPN1;EPN3 Epsin-1;Epsin-3 1 21095400.0 4674000.0 6223400.0 10198000.0 True False 6402104.110100646 5948429.609968289 7789442.434402782 1.0 0.9291366568974423 1.2167003691978895 22.610114707298678 -6.8415407415489655 1.2754081935503174 0.9623081123160275 1.226439029571737 0.9270334794547908 0.03304317079145708 0.16701574354112114 0.52710085405704 0.02031076269238105 0.046808186423828016 1.4403208861338365e-07 6.8415407415489655 0.26413091725570936 NIVHNYSEAEIK(ub)VR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIVHNYSEAEIKVR 14 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1;D6RFG3;D6REL6;I6L9I8;Q9H201-2;Q9H201;D6RBI9;D6RBR6 Q9Y6I3-3 EPN1;EPN3 Epsin-1;Epsin-3 1 28460000.0 5625000.0 12246000.0 10589000.0 True False 4677436.729751667 12180028.367359312 12803110.941995798 1.0 2.603996391845576 2.737206654353941 22.15728670803003 -10.517355270801415 0.49388834330379333 2.478312524547676e-17 2.733036327918995 0.9995977686970156 0.015832064386048793 1.9439065853892294 0.23481024587030713 2.486988291745813 0.027352162988561197 3.038398473474573e-11 10.517355270801415 2.733036327918995 NIVHNYSEAEIK(ub)VR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIVHNYSEAEIKVR 14 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1;D6RFG3;D6REL6;I6L9I8;Q9H201-2;Q9H201;D6RBI9;D6RBR6 Q9Y6I3-3 EPN1;EPN3 Epsin-1;Epsin-3 1 99075000.0 13216000.0 52469000.0 33390000.0 True False 17108372.526307072 49549054.02604214 27313362.610331807 1.0 2.8961874631764024 1.596490991082454 24.02819919084778 -10.455155890204512 4.945923538555065 0.9974830246839318 2.246339227129534 0.5507847322937423 0.530598862854635 0.014743806726225788 0.001624179682347958 0.5143600222450706 0.1712500466126639 3.5062599399938247e-11 10.455155890204512 1.2488562024456025 NIVLSGGSTMFR ddPTM_RPMI8226_Bortezomib_1h_R1 2 NIVLSGGSTMFR 12 0 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 0 71880300.0 23168200.0 23262400.0 25449700.0 False True 30373734.561167933 19791740.59612499 22816409.174760494 1.0 0.651607083622448 0.7511887986250696 24.856320968226836 -10.24863368319927 7.92242372301086 1.0000003330047778 0.7013979411237593 0.9230088601775366 0.04065406491127988 2.3911848703440537e-07 2.2692539702697006e-08 0.039363172786273604 0.01312104302975186 5.641132709952182e-11 10.24863368319927 -0.29860239188101845 NIVLSGGSTMFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIVLSGGSTMFR 12 0 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 0 48043000.0 15703000.0 7042000.0 25298000.0 False True 15204516.860387625 9853907.32354486 18671694.876267865 1.0 0.648090788679861 1.2280360532147714 23.857996638147032 -6.742466543489352 1.6778131733618502 0.7912110292593302 1.2285511518937333 0.6158723757772943 0.1478517842958333 0.3133865968553443 1.7331483158537746 0.069688820777107 0.17053953745309974 1.8093952942979922e-07 6.742466543489352 0.43734012263440314 NIVLSGGSTMFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIVLSGGSTMFR 12 0 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 0 73843000.0 11909000.0 40911000.0 21023000.0 False True 18066823.664520863 33610112.41089807 16867794.835291747 1.0 1.8603221592792036 0.933633667351072 24.106839551916845 -6.662850212616865 1.962312701964918 1.5524850520773297 0.9374472217904041 0.24780505514943751 0.3660603895595487 0.4778412547699108 3.539933223316145 0.15053980867667172 0.4060519819297685 2.1734506688211866e-07 6.662850212616865 -0.6150378302869256 NIVLSGGSTMFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIVLSGGSTMFR 12 0 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 0 58966000.0 17798000.0 19247000.0 21921000.0 False True 24378401.572865017 18396603.89868235 16743711.277166417 1.0 0.7546271581299713 0.6868256406032551 24.539100199583125 -13.999999999997643 0.1804634650616589 2.274941082937325 0.6332242890587948 0.9994975850233639 0.003015415712486097 12.210737467774901 0.13467150559603927 5.459335709341121 0.050424224020025915 1.0000000000054277e-14 13.999999999997643 -1.6417167938785302 NIVLSGGSTMFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIVLSGGSTMFR 12 0 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 0 34028400.0 15703000.0 8058400.0 10267000.0 False True 13057740.26085164 8014987.799732829 12413782.230755577 1.0 0.6138112444894108 0.9506838076702512 23.63840191358131 -10.187118967616085 7.600576503258676 1.000000144410451 0.7822475260798311 0.35778074912600477 0.13752764802275777 3.366777013532618e-07 3.576600070659844e-08 0.13316066189911505 0.04438685753626802 6.499516227184613e-11 10.187118967616085 -0.21775261833061987 NIVLTGGNSLFPGFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIVLTGGNSLFPGFR 15 0 G3V1Y1;Q9GZN1 G3V1Y1 ACTR6 Actin-related protein 6 0 1474800.0 0.0 0.0 1474800.0 False True 0.0 0.0 1322201.8432805424 0.0 NIVLTGGNSLFPGFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIVLTGGNSLFPGFR 15 0 G3V1Y1;Q9GZN1 G3V1Y1 ACTR6 Actin-related protein 6 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 NIVPGWLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIVPGWLQR 9 0 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 2527400.0 1338300.0 1189100.0 0.0 False True 1754524.2601156367 1011690.9150754962 0.0 1.0 0.5766183677670083 0.0 20.74264846560033 -7.711134507304409 0.6440613259943156 1.000694804385315 4.706998246563939e-19 0.9875375173574158 0.04575301148890767 0.11984015894862683 0.15162911742977506 0.04285133933296135 0.0778811777598333 1.9447576686632032e-08 7.711134507304409 -1.000694804385315 down NIVPGWLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIVPGWLQR 9 0 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 4562270.0 1706400.0 858870.0 1997000.0 False True 1652231.2660361375 1201821.2699478809 1473925.7912841698 1.0 0.7273928866091285 0.8920820115093574 20.6559842070572 -10.300117654159264 5.4365916853435525 1.000029811071593 0.8097374493772191 0.6402323579070535 0.06723405369853236 2.4297623385643115e-05 3.1279685153631164e-06 0.06510928289027927 0.021699697522699075 5.0105147602850166e-11 10.300117654159264 -0.1902923616943739 NIVPGWLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIVPGWLQR 9 0 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 4822900.0 1338300.0 1676700.0 1807900.0 False True 1833105.6761976231 1602617.8498945655 1380911.2548692673 1.0 0.8742637539690815 0.7533178653036882 20.80585852712322 -6.971598726903419 0.21662357994281958 1.0582083935228028 0.5659713536799927 0.999992308455282 0.0002792565415531915 0.07578726362430677 0.007144043094133551 0.003438380599485828 0.012347785519310045 1.0675820746191018e-07 6.971598726903419 -0.4922370398428101 NIVSAFGIIPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIVSAFGIIPR 11 0 Q96PZ0;Q96PZ0-2 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 11344400.0 3724300.0 3790700.0 3829400.0 False True 4882593.366172502 3225142.336032867 3433170.422198608 1.0 0.6605387944810727 0.7031448586286623 22.219216201275703 -10.666214073229938 10.139658542421994 1.0001312706878354 0.6818418266538843 0.9867286315721097 0.017393852851647143 5.163736787974861e-05 1.6998416336270525e-06 0.016848316063180525 0.005613841868400977 2.1566810719266074e-11 10.666214073229938 -0.3182894440339511 NIVSAFGIIPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIVSAFGIIPR 11 0 Q96PZ0;Q96PZ0-2 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 12216600.0 6092700.0 2130800.0 3993100.0 False True 5899290.573475364 2981639.551975203 2947187.319567766 1.0 0.5054234089402844 0.49958334529562465 22.492110041143263 NIVSAFGIIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIVSAFGIIPR 11 0 Q96PZ0;Q96PZ0-2 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 13546700.0 3724300.0 3544800.0 6277600.0 False True 5101274.355423149 3388179.0149139664 4794960.171230329 1.0 0.6641828646820385 0.9399533993173338 22.282426262798595 -9.978408013170549 6.504636939507677 1.0000000448157582 0.8020681319996831 0.4071860411221577 0.11258284932517576 7.317228553593941e-08 1.1487167448269788e-08 0.10900789949135446 0.0363359583754138 1.0509740354779771e-10 9.978408013170549 -0.19793191281607514 NIVSAFGIIPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIVSAFGIIPR 11 0 Q96PZ0;Q96PZ0-2 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 11386600.0 6092700.0 2661700.0 2632200.0 False True 5066350.002374753 2647360.8937939154 3182580.850082281 1.0 0.5225380979507962 0.6281802182222918 22.27251531657754 -9.738119259287172 6.012249434393182 1.0000000109971456 0.5753591580848466 0.9556405127435255 0.043128215007966784 6.325973482352565e-09 1.3454687736946277e-09 0.04175871586117986 0.013919571538891388 1.8275982802303357e-10 9.738119259287172 -0.424640852912299 NIVSLLLSMLGHDEDNTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIVSLLLSMLGHDEDNTR 18 0 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 1255350000.0 414990000.0 349240000.0 491120000.0 False True 629570169.8328593 286915393.3754254 394049916.7344576 1.0 0.4557321917771244 0.6259030932788183 29.229791944077487 -10.38281482375843 5.1385964657731495 1.0003093995146208 0.5408176425279416 0.9066135854891296 0.06947197962486786 0.0002464121943186796 2.959599520624154e-05 0.06731036645448223 0.022421985009582503 4.141762353178082e-11 10.38281482375843 -0.4594917569866792 NIYVLQELDNPGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIYVLQELDNPGAK 14 0 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 31096000.0 4623000.0 12600000.0 13873000.0 False True 6060797.769195686 10720129.114415333 12437555.039212741 1.0 1.768765354439136 2.052131668610896 22.5310762742289 -10.533531583646766 0.21272589072058032 7.139480910462363e-17 2.2604726189475035 0.9993185943343459 0.011603295464588471 2.259538507511546 0.10839048837918337 1.3509244669174838 0.16018627290920112 2.927307977982719e-11 10.533531583646766 2.2604726189475035 NIYVLQELDNPGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIYVLQELDNPGAK 14 0 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 25208000.0 7572000.0 0.0 17636000.0 False True 7331631.0047032405 0.0 13016602.531340832 1.0 0.0 1.775403388821762 22.805702747307695 -6.753868882351989 1.6354256302248564 0.4147433504318347 1.7800239355311867 0.6655023632058812 0.4203133965371975 0.293337915183351 1.544726284660521 0.20292257482767873 0.4906764314699396 1.762508084101944e-07 6.753868882351989 1.365280585099352 NIYVLQELDNPGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIYVLQELDNPGAK 14 0 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 24057600.0 4623000.0 9979000.0 9455600.0 False True 6332248.031877464 9538094.783859877 7222382.024194823 1.0 1.5062730859315225 1.1405715612901286 22.594286335751793 -10.196711073512116 9.398972792972321 0.9999999908867223 1.3234223236108256 0.5104897175489929 0.14929702225487737 2.8518756025886942e-08 2.520978946529264e-09 0.14455622451598013 0.04818540673595816 6.357537440597869e-11 10.196711073512116 0.32342233272410326 NIYVLQELDNPGAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 NIYVLQELDNPGAKR 15 1 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 75779000.0 19217100.0 29837600.0 26724300.0 True False 25193804.19866114 25385946.38605383 23959125.793587036 1.0 1.0076265650823348 0.9509927760278569 24.586565645916988 -6.872927842759087 1.1184428578471208 1.004400339106679 0.9474853960849613 0.9675212628819605 0.0045223532549606 0.13408099873006066 0.31169039404926613 0.0031320192567600635 0.007455546283693375 1.3398992907711478e-07 6.872927842759087 -0.05691494302171762 NIYVLQELDNPGAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 NIYVLQELDNPGAKR 15 1 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 118487200.0 27512300.0 39600900.0 51374000.0 True False 26638937.09597161 55413745.885965385 37917608.21303606 1.0 2.080178562918156 1.423390433200506 24.667033183671656 -10.180533790199709 5.764290194563489 0.9999957096896547 1.7517844977170998 0.6359568992821805 0.2681326312153758 4.894979175114672e-05 6.9585854954284125e-06 0.2596231998753893 0.08653943459677835 6.598818902809985e-11 10.180533790199709 0.7517887880274451 NIYVLQELDNPGAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 NIYVLQELDNPGAKR 15 1 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 184548000.0 11880000.0 16774000.0 155894000.0 True False 18022828.54433686 13780548.644139813 125081482.56923257 1.0 0.7646163092679447 6.940169366951878 24.10332211302401 -6.898039326962743 0.9735942545525993 0.7292484060857852 7.56316172546935 0.9855649137742932 0.3432958062786071 0.11286242366699288 0.18567740698819482 0.2654054385543813 0.6839805950887944 1.264621826128222e-07 6.898039326962743 6.833913319383565 up NIYVLQELDNPGAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NIYVLQELDNPGAKR 15 1 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 76096900.0 19217100.0 26338800.0 30541000.0 True False 26322181.192600574 25175064.725235824 23327844.81163904 1.0 0.9564201591436801 0.8862428474657232 24.64977570743988 -6.964054873011512 0.3739819685881902 1.0051588712537216 0.8350462700803265 0.9998922122360631 0.0004864951700834727 0.07828392746037381 0.016004482146036808 0.0009197683992255527 0.005947618563241464 1.0862883626519945e-07 6.964054873011512 -0.1701126011733951 NIYVLQELDNPGAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NIYVLQELDNPGAKR 15 1 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 94396500.0 27512300.0 33981200.0 32903000.0 True False 22877696.451546095 33798136.53085993 39782865.1737168 1.0 1.4773400198941717 1.7389366651478688 24.447438459105932 -10.197873216806327 0.12386429063530131 3.8872582964208066e-20 2.258664319177704 0.9998392253614897 0.0038790373919568664 1.8909428334196405 0.06149120087332192 0.8919176840516109 0.30260340954903564 6.340547832786889e-11 10.197873216806327 2.258664319177704 NIYVLQELDNPGAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NIYVLQELDNPGAKR 15 1 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 355618000.0 11880000.0 43737000.0 300001000.0 True False 15378894.1898099 41302997.50208711 245403896.2702052 1.0 2.6856935870886343 15.957187379103663 23.87444843511646 -6.930395946593863 0.7435447392660284 0.8011089402623287 18.70934141091362 0.9966152770699571 0.38915854698949665 0.09243308698812573 0.07667963324707208 0.3553783331541429 1.198241085077811 1.1738268881253182e-07 6.930395946593863 17.908232470651292 NK(ub)AAALLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKAAALLR 8 1 P13051;P13051-2;F5GYA2;Q68DM5 P13051 UNG;DKFZp781L1143 Uracil-DNA glycosylase 1 24845500.0 7131600.0 9506500.0 8207400.0 True False 9349596.662512653 8088167.256046757 7358176.978940012 1.0 0.8650819439598271 0.7870047494607689 23.156472698437398 -13.999999998192079 0.06094727256310757 1.8498719162702062 0.4419927077563618 0.9999517395627323 0.0006111743835587842 12.454255710777597 0.06348537744265852 1.6039931225776096 0.3228386650433929 1.0000000041628917e-14 13.999999998192079 -1.4078792085138443 NK(ub)AAALLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKAAALLR 8 1 P13051;P13051-2;F5GYA2;Q68DM5 P13051 UNG;DKFZp781L1143 Uracil-DNA glycosylase 1 60046000.0 12360000.0 20800000.0 26886000.0 True False 11967638.565521952 29105548.470567044 19843750.03728905 1.0 2.4320210132697673 1.658117424640288 23.51263517439573 -10.269430402791723 5.036338494112604 0.9997813501059127 2.0450692189554847 0.7085731494044164 0.3159448170434205 0.000775827676302289 0.00011254174119575777 0.3059742507229678 0.10197075122724907 5.377366003869878e-11 10.269430402791723 1.045287868849572 NK(ub)AAALLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKAAALLR 8 1 P13051;P13051-2;F5GYA2;Q68DM5 P13051 UNG;DKFZp781L1143 Uracil-DNA glycosylase 1 34225700.0 14573000.0 6511700.0 13141000.0 True False 22108306.429008555 5349636.258855677 10543675.590095095 1.0 0.24197404156821167 0.47691014343191035 24.398085178282404 -10.154852502758144 5.242429965392768 1.0000237646724177 0.3594420925022274 0.908356758862233 0.09591226195541978 268503240.44980764 10.938679542668224 77024.70128436323 0.03283331838375038 7.000797201716663e-11 10.154852502758144 -0.6405816721701902 NK(ub)AAALLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKAAALLR 8 1 P13051;P13051-2;F5GYA2;Q68DM5 P13051 UNG;DKFZp781L1143 Uracil-DNA glycosylase 1 27595700.0 7131600.0 6889100.0 13575000.0 True False 9768345.244243426 6584716.782792773 10368864.585900933 1.0 0.6740872295308364 1.0614760562451862 23.21968275996029 -6.683598585263644 1.8889390167613223 0.7944640531044473 1.0600518379311055 0.34075103281011787 0.13802170439049677 0.4305726163223662 2.973292929255674 0.05856275311634051 0.15375610048948357 2.072055647574635e-07 6.683598585263644 0.2655877848266581 NK(ub)AAALLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKAAALLR 8 1 P13051;P13051-2;F5GYA2;Q68DM5 P13051 UNG;DKFZp781L1143 Uracil-DNA glycosylase 1 50860200.0 12360000.0 30511000.0 7989200.0 True False 10277887.640841011 30346631.1870407 9659704.78211284 1.0 2.952613634970378 0.9398531215430191 23.293040449830006 -6.653064929392905 1.9973717982635033 2.263948841720662 0.9482712950034287 0.20667231127516672 0.8327680397120345 0.5010566230258834 3.8349144147995236 0.3377121204890909 0.9226962859982752 2.2229775185471582e-07 6.653064929392905 -1.3156775467172335 NK(ub)AAALLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKAAALLR 8 1 P13051;P13051-2;F5GYA2;Q68DM5 P13051 UNG;DKFZp781L1143 Uracil-DNA glycosylase 1 29563400.0 14573000.0 8905100.0 6085300.0 True False 18865035.77677611 8409523.356787983 4977837.840450799 1.0 0.4457729874618402 0.263865804409382 24.169211500374853 -13.999999999999998 0.15574366423624889 3.706386885873337 0.07636981592972421 0.9995482150776132 0.006654508774006672 11.98400279505358 0.12455558921025225 9.802447755299468 0.17001963520107632 1.0000000000000041e-14 13.999999999999998 -3.6300170699436127 NK(ub)AGTPVSELTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKAGTPVSELTK 12 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 13913400.0 4226300.0 5548700.0 4138400.0 True False 5540720.22754742 4720855.588663202 3710198.0663359016 1.0 0.8520292299170773 0.6696237878767988 22.401642090937045 -6.9683129691885375 0.29571712302296504 1.0332893475767517 0.48268269848196743 0.9999660698053637 0.00078704497369689 0.07685397683070991 0.010979065935765028 0.0030923385290269555 0.016434961046650477 1.0756897511362422e-07 6.9683129691885375 -0.5506066490947843 NK(ub)AGTPVSELTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKAGTPVSELTK 12 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 23716800.0 7303800.0 5282700.0 11130300.0 True False 7071944.866897989 7392109.65891657 8214940.528157346 1.0 1.045272523760358 1.161623949673227 22.753675596801976 -6.954866883478916 0.5025822249144538 0.9977210964499018 1.2142158072743172 0.9995299318166847 0.0014759567799243086 0.08158831355202288 0.028315016743848603 0.001722625460313149 0.00959888163657093 1.1095148428918709e-07 6.954866883478916 0.2164947108244154 NK(ub)AGTPVSELTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKAGTPVSELTK 12 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 10248700.0 3122800.0 3084200.0 4041700.0 True False 4737515.907260536 2533800.4130354156 3242856.22345996 1.0 0.534837341475141 0.6845056115780176 22.175699356784655 -10.3515911220809 4.987552610653073 1.000227749219291 0.6096714765264934 0.9006812407938515 0.06110181540648087 0.00015482839189814903 2.0128357575279015e-05 0.0591956874984239 0.019720526124319106 4.450500743432359e-11 10.3515911220809 -0.3905562726927976 NK(ub)AGTPVSELTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKAGTPVSELTK 12 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 14635500.0 4226300.0 2905200.0 7504000.0 True False 5788877.321463059 2776838.6577883265 5731709.749731169 1.0 0.47968517962763096 0.990124583998363 22.464852152459937 -10.922312301890216 10.709953924974362 1.0390274398305919 0.7349048818129971 0.26450484266008034 0.20838601421974381 0.11575477882719792 0.0008396589391881985 0.12027210936281854 0.06725629688796748 1.1958802625317672e-11 10.922312301890216 -0.3041225580175948 NK(ub)AGTPVSELTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKAGTPVSELTK 12 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 27817500.0 7303800.0 12422200.0 8091500.0 True False 6073433.3132018205 12355279.14298635 9783395.239131076 1.0 2.034315436728297 1.6108508539749522 22.534080872236252 -10.13616551398304 4.625878383881823 0.9999197915990732 1.822583145364395 0.8341931538419972 0.17287869203277617 120769410.8448898 17.635342005329115 106795.38729541551 0.059180974578638905 7.308604921357066e-11 10.13616551398304 0.8226633537653218 NK(ub)ALLFSNNTQELHPDPFQTEDPFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKALLFSNNTQELHPDPFQTEDPFK 25 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 11183200.0 3801300.0 4684000.0 2697900.0 True False 4983541.111841566 3985165.4580889936 2418747.188084195 1.0 0.7996654123349566 0.4853470923189387 22.248739799373503 -6.964499385500516 0.36654254634990996 1.0251388828393577 0.2489918338634084 0.9999024503950855 0.0020920482605729335 0.07813125957872194 0.0154614412474829 0.00416603170180421 0.02674542852628216 1.0851770850892852e-07 6.964499385500516 -0.7761470489759493 down NK(ub)ALLFSNNTQELHPDPFQTEDPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKALLFSNNTQELHPDPFQTEDPFK 25 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 52628000.0 18242400.0 18407700.0 15977900.0 True False 17663304.997384906 25757990.60488738 11792808.663274601 1.0 1.4582769537581395 0.6676445130184048 24.07425197646334 -6.749552821369029 1.6514992929517522 1.2696148691441014 0.6661260927505317 0.6470544719993969 0.1925666933324795 0.30082093660575726 1.614145869400561 0.09211552825588354 0.22373673893101856 1.780111388398564e-07 6.749552821369029 -0.6034887763935697 NK(ub)ALLFSNNTQELHPDPFQTEDPFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKALLFSNNTQELHPDPFQTEDPFK 25 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 12548400.0 3801300.0 3064500.0 5682600.0 True False 5206743.336269911 2929100.25705367 4340486.916820674 1.0 0.562558987044686 0.8336279775085247 22.311949860896394 -10.438876675454983 5.896529329874906 1.0001483174834518 0.6980934822766055 0.6232040476582421 0.11066345195462785 0.00021587696519959713 2.0543439693061508e-05 0.10720162825798658 0.035716475537841436 3.640183900284432e-11 10.438876675454983 -0.3020548352068463 NK(ub)ALLFSNNTQELHPDPFQTEDPFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKALLFSNNTQELHPDPFQTEDPFK 25 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 47902400.0 18242400.0 17995200.0 11664800.0 True False 15169363.875346107 17898256.28583248 14103855.748058613 1.0 1.1798949799682428 0.9297592083594749 23.854657251897617 -6.713687552403497 1.7817918258690824 1.11017627146148 0.930274277056523 0.482668345945393 0.07576480013450053 0.3677377665800831 2.277954708050679 0.033807839898187746 0.08551456218304587 1.933358746954521e-07 6.713687552403497 -0.17990199440495702 NK(ub)ALLFSNNTQELHPDPFQTEDPFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKALLFSNNTQELHPDPFQTEDPFK 25 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 47810200.0 15770200.0 22225500.0 9814500.0 True False 20414834.777116187 20988631.38721534 8028361.705274086 1.0 1.0281068456523754 0.39326116487963947 24.283114555693302 -6.896538142413819 0.9828591178244386 1.0289595995603409 0.3311086257941994 0.9847649484998668 0.03614894137749177 0.11399983581649199 0.19212309588549512 0.0277534946388318 0.07103645442413753 1.269000688101684e-07 6.896538142413819 -0.6978509737661415 down NK(ub)CYTAVVPLVYGGETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKCYTAVVPLVYGGETK 17 1 D6RD17;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 1 180245300.0 31959600.0 32394400.0 115891300.0 True False 41899345.09720663 27561281.792382162 103899979.98384756 1.0 0.6577974364143375 2.479751884970976 25.32042435843697 -6.85813292547204 1.19511077205712 0.815175445394958 2.56489473772658 0.951332725833574 0.1744247736912762 0.14873796368694323 0.4047414114883706 0.11391491274352401 0.2653813528308689 1.386331446399217e-07 6.85813292547204 1.749719292331622 up NK(ub)CYTAVVPLVYGGETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKCYTAVVPLVYGGETK 17 1 D6RD17;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 1 95227700.0 2199100.0 26874700.0 66153900.0 True False 2129290.7742264825 37605907.859709024 48826209.015540205 1.0 17.661236461877923 22.930738068537178 21.02194154583588 -8.84029596961186 0.5461361772609178 1.1827476169962277e-15 22.844736946217576 0.9954908142804597 0.6276650442377949 0.38817303183032636 0.21640402904407918 2.361995854735025 1.006900689956996 1.4444550460374892e-09 8.84029596961186 22.844736946217576 NK(ub)CYTAVVPLVYGGETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKCYTAVVPLVYGGETK 17 1 D6RD17;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 1 754606700.0 33418700.0 272235000.0 448953000.0 True False 50698611.13422817 223652537.2682369 360217242.7669101 1.0 4.41141349367739 7.105071218089375 25.595442889996235 -7.83574473491351 0.2825380938599076 6.315771721567879e-22 9.173151351397047 0.9994392766063862 0.059154477048911525 0.12385976754156447 0.04816149630666018 0.40528224875685637 0.7374133593976304 1.459671958964568e-08 7.83574473491351 9.173151351397047 NK(ub)CYTAVVPLVYGGETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKCYTAVVPLVYGGETK 17 1 D6RD17;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 1 287835000.0 31959600.0 27563400.0 228312000.0 True False 43775927.79571508 26345557.848025173 174389407.83323836 1.0 0.601827515135018 3.983682736481216 25.38363441995986 -6.877543569469641 1.0934699617725196 0.7604241614970847 4.212284998835343 0.9716465986391346 0.2541180241992551 0.12982526464701927 0.2856593197833105 0.1794051582320595 0.431244297206862 1.325734110246163e-07 6.877543569469641 3.451860837338258 up NK(ub)CYTAVVPLVYGGETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKCYTAVVPLVYGGETK 17 1 D6RD17;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 1 189467200.0 2199100.0 27822100.0 159446000.0 True False 1828649.086648339 27672216.82504557 192785421.4049921 1.0 15.132600905822189 105.42505000691037 20.802346821270156 -6.93447678639103 0.7111524682458946 9.631406734047308e-16 126.12555848956508 0.9973709612439567 2.371767393111647 0.08991735486443761 0.06691513704118367 2.2284509922037565 7.936756693382335 1.1628487051288158e-07 6.93447678639103 126.12555848956508 NK(ub)CYTAVVPLVYGGETK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKCYTAVVPLVYGGETK 17 1 D6RD17;P01591 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 1 1050695700.0 33418700.0 247637000.0 769640000.0 True False 43261165.93106065 233855783.25958166 629573417.1732792 1.0 5.405674540354399 14.552853665029359 25.366569212088685 -6.959306617029321 0.44509776122768985 0.6897863648631299 19.62841296700498 0.9997436133446597 0.09038289880907853 0.07994974579019294 0.02205352780495536 0.12140677896484155 0.7572103956430568 1.0982302021772903e-07 6.959306617029321 18.93862660214185 NK(ub)DNHCMEVIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKDNHCMEVIR 11 1 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;Q9BRT8-2;A0A087X140 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 1 4401830.0 878830.0 1344200.0 2178800.0 True False 1152154.6406018275 1143650.5996505604 1953358.6765253888 1.0 0.9926190108067221 1.6953962668631466 20.13590293563276 -6.90452901425477 0.9322113598398911 0.9742993663041659 1.7763370064400763 0.9886872786410773 0.03505310664107681 0.10814773426920188 0.1592237931509219 0.027943640587721627 0.07450239820528101 1.2458650010023625e-07 6.90452901425477 0.8020376401359104 NK(ub)DNHCMEVIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKDNHCMEVIR 11 1 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;Q9BRT8-2;A0A087X140 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 1 4581510.0 787510.0 1212900.0 2581100.0 True False 762510.9261111809 1697217.2951899436 1905032.4786597753 1.0 2.225826853191182 2.4983674507793276 19.540398484699345 -10.401572034411561 0.32379674360051686 5.541133174023358e-15 2.567642829219896 0.9990508646943622 0.020076597580627277 1.8982110586281873 0.15367624909717706 1.685187909872172 0.08872679157693696 3.96668729872342e-11 10.401572034411561 2.5676428292198907 NK(ub)DNHCMEVIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKDNHCMEVIR 11 1 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;Q9BRT8-2;A0A087X140 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 1 4429830.0 878830.0 1008800.0 2542200.0 True False 1203757.2004877515 964227.8803445082 1941784.718252472 1.0 0.8010152545329007 1.613103304774151 20.199112997155652 -6.841909276127074 1.27345287995848 0.8941566389813621 1.6408471901336066 0.9276970201396454 0.09293013083294412 0.16657786788683257 0.5239079456462502 0.05720241887547554 0.13186188667162207 1.439099173865376e-07 6.841909276127074 0.7466905511522445 NK(ub)DNHCMEVIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKDNHCMEVIR 11 1 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;Q9BRT8-2;A0A087X140 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 1 6349510.0 787510.0 1653800.0 3908200.0 True False 654849.4576083097 1644890.6511464017 4725386.550524876 1.0 2.511860752170422 7.215989103485383 19.32080376013362 -6.950627531576856 0.5519109188212372 0.9356681378013835 9.01390052427505 0.9992496167108275 0.07250591356633042 0.08323472388033384 0.03492699657779078 0.07850439033781606 0.3903900896268766 1.1203983702579718e-07 6.950627531576856 8.078232386473665 NK(ub)DNHCMEVIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKDNHCMEVIR 11 1 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;Q9BRT8-2;A0A087X140 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 1 3805310.0 493210.0 621200.0 2690900.0 True False 638470.0676225709 586629.6739213131 2201183.810965612 1.0 0.9188052873108172 3.447591238164094 19.28425946037153 -6.89948273861122 0.9645481594369317 0.8933649140052411 3.710244172776676 0.9863067410825844 0.1373105164684281 0.11178648686595916 0.17958199853460646 0.10687366159304745 0.2773475676434533 1.2604257335487758e-07 6.89948273861122 2.8168792587714346 up NK(ub)DQGTYEDYVEGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKDQGTYEDYVEGLR 15 1 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180 P60660-2 MYL6 Myosin light polypeptide 6 1 53679800.0 9574100.0 8047700.0 36058000.0 True False 9270175.436097374 11261188.57820107 26613328.083187103 1.0 1.2147762095581103 2.870854846992084 23.144165211129966 -6.930788396227646 0.740296335764422 0.975538526516275 3.217762497350562 0.9966908790899218 0.04808612161425981 0.09223049675197438 0.07569087127319239 0.04401600880077947 0.1492021729647304 1.1727666401294205e-07 6.930788396227646 2.242223970834287 up NK(ub)DQGTYEDYVEGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKDQGTYEDYVEGLR 15 1 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180 P60660-2 MYL6 Myosin light polypeptide 6 1 200374300.0 16775000.0 97184000.0 86415300.0 True False 25448901.416771956 79840755.89794235 69335278.07782856 1.0 3.1372967575458386 2.7244900258104474 24.60110004331079 -9.980915348064613 5.324424298834663 0.999992760344573 2.9308933916845263 0.9668563623231777 0.1685276425453068 1.448310336600564e-05 2.7724754909992337e-06 0.16317679720871783 0.05439206274290218 1.0449238741411177e-10 9.980915348064613 1.9309006313399535 NK(ub)DQGTYEDYVEGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKDQGTYEDYVEGLR 15 1 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180 P60660-2 MYL6 Myosin light polypeptide 6 1 51723400.0 5846400.0 11588000.0 34289000.0 True False 8007972.07301934 11076003.843608392 26190644.404122032 1.0 1.3831221865678007 3.2705713962670035 22.933005512255978 -6.9401360978628 0.6582952504092785 0.9788625488767665 3.7816022280000725 0.9981816837369332 0.04232008127204998 0.08770457880738351 0.05432713529573925 0.04123804173103174 0.1623517822323988 1.1477938730340645e-07 6.9401360978628 2.802739679123306 up NK(ub)DQGTYEDYVEGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKDQGTYEDYVEGLR 15 1 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180 P60660-2 MYL6 Myosin light polypeptide 6 1 52475000.0 9574100.0 10890000.0 32010900.0 True False 7961288.354544966 10831333.408504238 38704231.18832115 1.0 1.3605000756342172 4.8615537416410195 22.924570486564242 -6.926677858525774 0.7735750557565745 0.9396906498183959 5.523052544545111 0.9958440376055919 0.11227612013685567 0.09440002851019677 0.08640268643596125 0.10033525301606111 0.3227653278083278 1.1839194119867414e-07 6.926677858525774 4.583361894726715 up NK(ub)DQGTYEDYVEGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKDQGTYEDYVEGLR 15 1 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180 P60660-2 MYL6 Myosin light polypeptide 6 1 318834500.0 16775000.0 90795500.0 211264000.0 True False 21715568.18468528 85742650.6093409 172816119.7516965 1.0 3.948441499670738 7.958167075433633 24.37222636540324 -6.966834988734662 0.3250241240995304 0.48225885440869465 11.55464447003761 0.9999461255005777 0.020930914430855315 0.07734368550217162 0.012693277818897425 0.05959115705935386 0.35117595901381443 1.0793567486027876e-07 6.966834988734662 11.072385615628916 NK(ub)DQSEQETSDADQHVTSNASDSESSYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKDQSEQETSDADQHVTSNASDSESSYR 28 1 A0A590UJD9;A0A590UJ08;Q12959-2;Q12959-4;A0A0C4DFT3 A0A590UJD9 DLG1 Disks large homolog 1 1 5273470.0 2162600.0 2430200.0 680670.0 True False 2962171.662067531 2322825.7284032768 519909.7648386872 1.0 0.7841631051125495 0.17551641975934695 21.498223818606366 -7.077616095205559 0.5792819080832743 1.0046662574494376 7.917899662306267e-13 0.9990551706607786 0.010730525102664165 0.07548324247848597 0.03919932595697499 0.011318631457070195 0.04512162338347454 8.363419956899029e-08 7.077616095205559 -1.0046662574486458 down NK(ub)DQSEQETSDADQHVTSNASDSESSYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKDQSEQETSDADQHVTSNASDSESSYR 28 1 A0A590UJD9;A0A590UJ08;Q12959-2;Q12959-4;A0A0C4DFT3 A0A590UJD9 DLG1 Disks large homolog 1 1 9662030.0 4620900.0 4314000.0 727130.0 True False 3842483.090579464 4290759.625738047 879169.5211307391 1.0 1.1166632421252844 0.22880244373389197 21.873607480459263 -6.873829962715544 1.113699643817184 1.0677779563771206 0.17289023962792155 0.9683553327174313 0.07007663443797353 0.1332324977546944 0.3065485860285065 0.048712161300639996 0.11615343683023414 1.3371189299871315e-07 6.873829962715544 -0.8948877167491991 down NK(ub)EDEDIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKEDEDIAK 9 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 19264200.0 6314000.0 6661100.0 6289100.0 True False 8277715.1448629815 5667289.84476443 5638364.261307063 1.0 0.684644221936226 0.6811498297094871 22.980801172305945 NK(ub)EDEDIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKEDEDIAK 9 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 18471600.0 5603400.0 6798200.0 6070000.0 True False 5425523.134146087 9512756.712144664 4480084.903903308 1.0 1.7533344669153013 0.8257424755425765 22.37133081962812 -6.690722103206019 1.8641689881405947 1.4719781988418563 0.8289470068524605 0.37370370598521674 0.3185612223410774 0.4150959845670536 2.7974174778447383 0.13668864111629536 0.3555812476419908 2.0383459593785046e-07 6.690722103206019 -0.6430311919893958 NK(ub)EDEDIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKEDEDIAK 9 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 16595600.0 6314000.0 4651700.0 5629900.0 True False 8648456.4294342 4446172.512885164 4300233.571430102 1.0 0.5141001228558009 0.49722555770699906 23.044011233828837 NK(ub)EDEDIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKEDEDIAK 9 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 15404700.0 5603400.0 6217900.0 3583400.0 True False 4659475.372709422 6184402.938543483 4332672.372230399 1.0 1.3272745199525189 0.9298627046312745 22.151736095062397 -6.687937786319487 1.8738513254314353 1.2055762360814737 0.931273076717631 0.36075932380507114 0.13847260918161927 0.42110644191092594 2.865211650073027 0.05915416537512128 0.1544370457875694 2.0514560335588544e-07 6.687937786319487 -0.27430315936384264 NK(ub)EEAAEYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKEEAAEYAK 10 1 P62753;A2A3R5 P62753 RPS6 40S ribosomal protein S6 1 1479290.0 417030.0 488040.0 574220.0 True False 546730.3685242648 415226.33436501987 514805.22270718287 1.0 0.759471868163825 0.9416071474074976 19.06046998771445 -10.517720475914022 5.109395985039558 1.0005132977305833 0.8505395077856589 0.4730877449718506 0.07435641638439607 0.0004362468806101573 4.1177723786665844e-05 0.07223993574639209 0.023998430195034656 3.035844510029833e-11 10.517720475914022 -0.14997378994492438 NK(ub)ELTDEFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKELTDEFR 9 1 O60427;A0A0A0MR51;O60427-2;H7C2V0;F5H852;F5GWE3;F5H1Q7;F5GYH4;C9JJB3;F5H5X5;F5H2H3;F5H0Y2;C9J425 O60427 FADS1 Fatty acid desaturase 1 1 31218980.0 242220.0 1810860.0 29165900.0 True False 234530.85868452478 2533945.841510145 21526475.831755105 1.0 10.804317417856895 91.78525995468716 17.839418234030934 -6.929211191776418 0.7552937538187348 1.5507332270375426e-18 107.9696022984372 0.9964690740351703 2.4174522199966417 0.09219499193905233 0.07951897506035081 2.2045581551263727 7.291411302217115 1.1770334582168661e-07 6.929211191776418 107.9696022984372 NK(ub)ELTDEFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKELTDEFR 9 1 O60427;A0A0A0MR51;O60427-2;H7C2V0;F5H852;F5GWE3;F5H1Q7;F5GYH4;C9JJB3;F5H5X5;F5H2H3;F5H0Y2;C9J425 O60427 FADS1 Fatty acid desaturase 1 1 24630450.0 242220.0 2759630.0 21628600.0 True False 201416.66216541335 2744763.325446335 26151040.26065257 1.0 13.627290294346151 129.83553584646359 17.61982350946521 -6.926605836086275 0.7781936122301244 1.1795138590641982e-11 151.45728983325822 0.9960663023143342 3.6368963141917607 0.09252183727504508 0.08598438468632179 3.2891329256036927 10.499377469167095 1.1841157668532137e-07 6.926605836086275 151.45728983324642 NK(ub)EQWDQLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKEQWDQLPR 10 1 O95155-3;O95155-2;O95155;O95155-4;K7ERA7 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 8996500.0 3355100.0 1905300.0 3736100.0 True False 3248594.1869888874 2666096.226008244 2757503.3294024966 1.0 0.8206922972054693 0.8488297308561087 21.631384103393195 -10.588507953515055 9.48408696285523 1.000020676935248 0.8347610140437814 0.9787155809444252 0.011487059185913893 5.022806902278321e-06 2.1792499754136277e-07 0.011123686708866305 0.0037074324103286227 2.579241728677046e-11 10.588507953515055 -0.16525966289146654 NK(ub)EQWDQLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKEQWDQLPR 10 1 O95155-3;O95155-2;O95155;O95155-4;K7ERA7 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 23386800.0 4947400.0 9737100.0 8702300.0 True False 7505567.50338824 7999438.428690464 6982286.590646408 1.0 1.0658006106905675 0.9302809664285069 22.839529728894384 -6.774679625174283 1.5565677725611882 1.0375155156285714 0.929380639809261 0.7481239337249426 0.027770300335846734 0.2589305943009275 1.2387107211428385 0.014057397025576965 0.03332053253415335 1.680042912462734e-07 6.774679625174283 -0.10813487581931036 NK(ub)EQWDQLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKEQWDQLPR 10 1 O95155-3;O95155-2;O95155;O95155-4;K7ERA7 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 7051300.0 2125800.0 2362900.0 2562600.0 True False 2911765.7075849217 2258499.2649346143 1957366.6584036613 1.0 0.7756459453627744 0.6722267019303354 21.473462844467957 -13.999999999932411 0.10388806131956041 2.096461286992777 0.4646535683216856 0.9997741144040431 0.0020562548557974936 12.052033880550264 0.09675208902935142 2.8067990488517385 0.18476095742864299 1.0000000001556285e-14 13.999999999932411 -1.6318077186710913 NK(ub)EQWDQLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKEQWDQLPR 10 1 O95155-3;O95155-2;O95155;O95155-4;K7ERA7 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 9150600.0 3355100.0 3308700.0 2486800.0 True False 2789914.3061315236 3290875.3763744743 3006778.3823359264 1.0 1.1795614543220792 1.0777314470655213 21.41178937882747 -10.279509201674546 3.7702369067016477 0.9997546764986677 1.1286464506610616 0.6803124981628828 0.04157192652779529 14725983.848349942 12.952961148971946 31596.541400787326 0.01423117617759634 5.2540088298809793e-11 10.279509201674546 0.12889177416239395 NK(ub)EQWDQLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKEQWDQLPR 10 1 O95155-3;O95155-2;O95155;O95155-4;K7ERA7 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 20681200.0 4947400.0 8356600.0 7377200.0 True False 6404506.827833804 7891547.863958224 6034625.2964642 1.0 1.2321866579424634 0.9422466801405989 22.610656050986833 -6.693432993274318 1.8539500509479485 1.1450909430695484 0.9431970086991982 0.38669816702168536 0.09813056349390106 0.40931110595418874 2.7301678055113143 0.04229979305813127 0.10968815872140558 2.0256621194658744e-07 6.693432993274318 -0.2018939343703502 NK(ub)ESKDPADETEAD ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKESKDPADETEAD 14 2 P16949 P16949 STMN1 Stathmin 1 2731440.0 1019500.0 1361700.0 350240.0 True False 1336574.3728520437 1158539.667865028 314000.5245393116 1.0 0.8667977565609633 0.23492933196772497 20.350108687009556 -6.940985874116508 0.6503283758295058 1.0069895449977138 0.059477026186878675 0.9982901839419025 0.013799379641102104 0.08731977450859224 0.052583253834056036 0.013535189849931406 0.05415179020214026 1.1455502010612693e-07 6.940985874116508 -0.9475125188108351 down NK(ub)ESKDPADETEAD ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKESKDPADETEAD 14 2 P16949 P16949 STMN1 Stathmin 1 3737720.0 1019500.0 1963100.0 755120.0 True False 1396436.7009515618 1876363.7508964164 576776.2081845686 1.0 1.3436797741120825 0.4130342662804128 20.413318748532447 -6.806716468960262 1.42816088889404 1.1880437428032786 0.39792753652353235 0.8511136949116717 0.14826104067901189 0.2113118607497297 0.8500367299223587 0.08164053694060122 0.18915905289799087 1.5605709958830948e-07 6.806716468960262 -0.7901162062797462 down NK(ub)ESSDQTGINISGFENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKESSDQTGINISGFENK 18 1 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 15124400.0 3595300.0 4537100.0 6992000.0 True False 3481169.1694677244 6348787.690663926 5160585.444496207 1.0 1.823751556329756 1.4824288028740837 21.7311404937052 -10.329025116763198 5.633172994647541 0.9998915435060298 1.6530901796019255 0.8299757584882199 0.139344430594717 0.00018983253555266682 2.2611502293035084e-05 0.1349418004089962 0.044973221590004914 4.6878626981779214e-11 10.329025116763198 0.6531986360958957 NK(ub)ESSDQTGINISGFENK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKESSDQTGINISGFENK 18 1 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 12216400.0 3595300.0 5132600.0 3488500.0 True False 2989651.248795768 5104949.665058663 4217929.220998428 1.0 1.7075401912229522 1.4108432288540045 21.511545769139477 -10.114932429151056 4.6558544203873895 0.9999656155152203 1.559191709932869 0.8256698702340692 0.12112602779263942 5.3245303529330355e-05 1.0121514573700948e-05 0.117288627299636 0.039093257351702125 7.674808906053559e-11 10.114932429151056 0.5592260944176486 NK(ub)FDVDAADEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKFDVDAADEK 11 1 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 1 3653110.0 665120.0 951190.0 2036800.0 True False 644006.1296682814 1331005.1273903225 1503300.977309764 1.0 2.0667584764696336 2.334296069641594 19.29671489445364 -10.481805852444387 0.29412894492068875 9.255064349541175e-11 2.4250967800165326 0.9990764956302127 0.01751564929771124 2.0491637147086954 0.14247334467103487 1.628159672980084 0.09827390325779391 3.2975709426141806e-11 10.481805852444387 2.4250967799239818 NK(ub)FDVDAADEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKFDVDAADEK 11 1 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 1 4554120.0 665120.0 2077700.0 1811300.0 True False 553076.749811988 2066507.0177088392 2190034.455495038 1.0 3.7363838172754944 3.959729741377693 19.077120169887916 -10.153296691987672 0.5524620733027054 1.2084591761516889e-24 3.9422518421032806 0.9995366004505069 0.02896806141976605 1.4464477643391014 0.26032113831180087 2.3623544754453047 0.0414044447241521 7.025921740451668e-11 10.153296691987672 3.9422518421032806 NK(ub)FDVDAADEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKFDVDAADEK 11 1 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 1 9327100.0 3018700.0 1329200.0 4979200.0 True False 3907766.657472993 1255228.851539294 4073036.6909063817 1.0 0.3212138701114267 1.0422927078098012 21.8979128922709 -11.838848376082073 17.819642085319906 0.930364005804397 0.713577960076094 0.0 0.33864462662482814 0.0 0.0 0.0 0.09820135727329662 1.449277747182209e-12 11.838848376082073 -0.21678604572830307 NK(ub)GSFDEAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKGSFDEAAK 10 1 Q6PGP7;D6RCE2;H0Y915 Q6PGP7 TTC37 Tetratricopeptide repeat protein 37 1 2593000.0 731450.0 902420.0 959130.0 True False 958938.0333718767 767782.4536056084 859888.4282246174 1.0 0.8006590904585197 0.8967090659664682 19.87107806565987 -10.091800202678415 4.476388203618675 1.0000126894408918 0.8486840782043922 0.7679344454406256 0.039212238327403524 54545893.47507061 0.19914840048798635 7316.995411547824 0.013423392159816826 8.094682096514929e-11 10.091800202678415 -0.15132861123649965 NK(ub)GSFDEAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKGSFDEAAK 10 1 Q6PGP7;D6RCE2;H0Y915 Q6PGP7 TTC37 Tetratricopeptide repeat protein 37 1 1983760.0 731450.0 463430.0 788880.0 True False 1001886.8316930073 442954.1302419268 602562.7914935936 1.0 0.4421199243565409 0.6014279980857435 19.93428812718276 -10.719130328303674 10.363753142631262 1.0005871773255042 0.5217739612212069 0.9231665293154157 0.06503724875703802 0.0008832797647703924 2.393782954511889e-05 0.06303698335994226 0.02099068177659643 1.909280212852052e-11 10.719130328303674 -0.4788132161042973 NK(ub)GVYSSTNELTTDSTPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKGVYSSTNELTTDSTPK 18 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 15803800.0 6173700.0 5756600.0 3873500.0 True False 8093780.486195846 4897737.719051054 3472707.3772356827 1.0 0.6051236165107607 0.4290587548251989 22.948382291105027 -13.999999999999991 0.10932555083195339 2.9076124510826498 0.10291563740555515 0.9997464891111538 0.003800956898721817 12.016694507856597 0.10022354323585075 5.066262452101872 0.2897346221507032 1.0000000000000205e-14 13.999999999999991 -2.8046968136770944 NK(ub)GVYSSTNELTTDSTPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKGVYSSTNELTTDSTPK 18 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 20718200.0 6532100.0 6108800.0 8077300.0 True False 6324742.060990774 8548075.69697116 5961612.816194112 1.0 1.3515295350451175 0.942585920296048 22.592575213571042 -6.679177847275525 1.9045383472670148 1.2225751815932866 0.9441414850430481 0.32050513521889845 0.14901243105773998 0.4403397978657712 3.087297204024797 0.06279371778287265 0.16580525055346051 2.0932550745951573e-07 6.679177847275525 -0.27843369655023853 NK(ub)GVYSSTNELTTDSTPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKGVYSSTNELTTDSTPK 18 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 14746700.0 6173700.0 3940000.0 4633000.0 True False 8456283.72796926 3765917.77216233 3538780.8196301293 1.0 0.445339571531465 0.41847943298373125 23.01159235262792 -13.740610782212604 0.433981893962923 9.99999999998137 0.41804334659872966 0.9998772982223311 0.0029689278917248364 25.59729823772418 0.22142426788399264 217.7623790762307 0.006297629285660313 1.8171434700724796e-14 13.740610782212604 -9.58195665338264 NK(ub)GVYSSTNELTTDSTPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKGVYSSTNELTTDSTPK 18 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 12928710.0 6532100.0 731010.0 5665600.0 True False 5431730.571095275 727071.9040358764 6850250.765225364 1.0 0.1338564007399334 1.2611543734659234 22.372980489005318 -6.701435575394133 1.8255734039579523 0.46292346129068335 1.2579124875892518 0.42446773903124935 0.3655142592004818 0.3925473670663885 2.5443701628350834 0.15966412675197558 0.4099148379284735 1.988677795219528e-07 6.701435575394133 0.7949890262985684 NK(ub)IAGYVTHLMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKIAGYVTHLMK 12 1 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 1 7110770.0 817370.0 3630800.0 2662600.0 True False 1071579.985422339 3089098.7927475497 2387099.693462686 1.0 2.8827514835768895 2.227644903727709 20.03130810974029 -10.20248135446968 5.3877785782765155 0.99992148875415 2.5551981936525454 0.8825500003772679 0.2674461412959197 0.0002522326773658877 3.733620552320038e-05 0.2589664357589147 0.08631787093708615 6.273626299155617e-11 10.20248135446968 1.5552767048983953 NK(ub)IAGYVTHLMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKIAGYVTHLMK 12 1 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 1 16736500.0 1881200.0 4234300.0 10621000.0 True False 1821482.3357168173 5925078.07158279 7839041.476829823 1.0 3.2528880216952882 4.303660443539182 20.79668157357461 -9.004511102472236 0.2880904497654979 7.51045574731319e-16 4.828959683647758 0.9987662264673556 0.04840784719492389 0.46910761775729154 0.09942870598556297 0.8747283540312655 0.3748327594241565 9.896665633266168e-10 9.004511102472236 4.828959683647757 NK(ub)IAGYVTHLMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKIAGYVTHLMK 12 1 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 1 7264170.0 817370.0 0.0 6446800.0 True False 1119573.7775937007 0.0 4924198.616013712 1.0 0.0 4.398279697651806 20.094518171263182 -6.846939444523273 1.2497716836654507 0.46746356889915786 4.563990453582965 0.9357345023983386 0.4772176755359905 0.16085376176121577 0.48501881966543287 0.2990150465046747 0.6907193658345161 1.4225271221382342e-07 6.846939444523273 4.096526884683808 NK(ub)IAGYVTHLMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKIAGYVTHLMK 12 1 H3BNC9;P08708;H0YN88;A0A075B716 H3BNC9 RPS17 40S ribosomal protein S17 1 9971900.0 1881200.0 6050500.0 2040200.0 True False 1564301.1512904596 6017904.755569788 2466796.3871810194 1.0 3.84702443682622 1.5769319003224236 20.577086849008886 -6.589586747918649 2.229824510394671 2.9273686608063 1.5833962791518665 0.0 1.233827283450201 0.6708169011318817 6.287067936035623 0.46196215715171957 1.3758471587159666 2.5728428019899536e-07 6.589586747918649 -1.3439723816544333 NK(ub)IQILASEVEEEEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKIQILASEVEEEEER 16 1 Q7L2Z9 Q7L2Z9 CENPQ Centromere protein Q 1 18130600.0 5800500.0 5175700.0 7154400.0 True False 5616366.302533175 7242384.000918944 5280448.012600638 1.0 1.2895141824443288 0.9401893908199994 22.421205601407955 -6.6866057717812595 1.8780952236889557 1.1820737958860448 0.9414299780922185 0.35480409738956054 0.12252856182592257 0.4239794511816027 2.8966382030604554 0.05223966251452106 0.13663976681473172 2.0577576656602844e-07 6.6866057717812595 -0.24064381779382626 NK(ub)ITITNDQNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKITITNDQNR 11 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 14272000.0 4162400.0 4087800.0 6021800.0 True False 5456946.708738934 3477916.1741195973 5398721.901184413 1.0 0.6373373902570733 0.989330149136095 22.37966252408229 -10.745414724579645 9.754860050907693 1.0006132280668383 0.8133337699592896 0.27271426742130367 0.14370044206801935 0.0019224076376089345 5.0171368596251724e-05 0.13956802865767823 0.046379118247673566 1.7971539237341227e-11 10.745414724579645 -0.18727945810754865 NK(ub)ITITNDQNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKITITNDQNR 11 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 22853000.0 4952800.0 7942800.0 9957400.0 True False 4795576.075025649 11114401.461154811 7349258.224403108 1.0 2.3176363563569087 1.5325079009123634 22.19327270065979 -10.050210393013428 4.867489097593625 0.9999804219717634 1.9250721286464945 0.6492469664988787 0.3205273497725074 222014853.55472118 1.4730055006886589 54826.078853954066 0.10972503734835903 8.908192781297272e-11 10.050210393013428 0.9250917066747311 NK(ub)ITITNDQNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKITITNDQNR 11 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 40147700.0 12655100.0 12609400.0 14883200.0 True False 19198711.91173719 10359154.052308127 11941528.996461703 1.0 0.5395754725594392 0.6219963636811079 24.194506184486762 -10.81155825511662 7.244092074814011 1.0180861659746072 0.5807859181202736 0.9718257373556898 0.03364818789892944 0.009397785767121698 0.00024446578066438646 0.031151491389064603 0.0108599059468843 1.543269399352208e-11 10.81155825511662 -0.43730024785433363 NK(ub)ITITNDQNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKITITNDQNR 11 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 15534000.0 4162400.0 3782100.0 7589500.0 True False 5701351.764630483 3614994.316267805 5797016.41065894 1.0 0.6340591609684867 1.0167792919956162 22.44287258560518 -10.989850144532646 12.083845811795348 1.131627649145694 0.8254192264820515 0.21718431929432047 0.15624483921793128 0.06811285044870308 5.7211564434020185e-05 0.018597772474090436 0.05042780501849195 1.0236461455337665e-11 10.989850144532646 -0.30620842266364257 NK(ub)ITITNDQNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKITITNDQNR 11 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 20376300.0 4952800.0 9496000.0 5927500.0 True False 4118472.6462424975 9444843.163191585 7166912.844336588 1.0 2.293287821592944 1.7401870693193373 21.973677976094066 -10.049450590053544 5.62348827967225 0.9999954101037987 2.0167374454564917 0.8183651253192501 0.2258024365712156 1.2993750465765736e-05 2.196852138622609e-06 0.2186332554392218 0.0728774230309344 8.923791403283948e-11 10.049450590053544 1.016742035352693 NK(ub)ITITNDQNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKITITNDQNR 11 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 37418000.0 12655100.0 10572900.0 14190000.0 True False 16382276.419315118 9984508.820673954 11607565.601695368 1.0 0.6094701716119235 0.7085441183259339 23.96563250657921 -9.947123516299499 6.7324304628465885 1.0000000278181063 0.6590071449689285 0.9404572742681504 0.040446769375513426 1.6866695270954147e-08 2.643733188654722e-09 0.03916241925941197 0.01305413868326971 1.1294746387320826e-10 9.947123516299499 -0.3409928828491777 NK(ub)LASTPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKLASTPFK 9 1 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 7086400.0 1138400.0 2296700.0 3651300.0 True False 1102262.1151286557 3213784.2871322753 2694914.9933479666 1.0 2.915626186387766 2.4448948724264348 20.072035903243112 -10.10595147990772 5.267317054477102 0.9999671803954676 2.6802605294086845 0.9444078126226804 0.19217525419806253 7.406917142919744e-05 1.2571912020172098e-05 0.1860764917446061 0.06202429658772387 7.835171737011211e-11 10.10595147990772 1.6802933490132168 NK(ub)LDHYAIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKLDHYAIIK 10 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9 P62750 RPL23A 60S ribosomal protein L23a 1 32070400.0 9592400.0 12322000.0 10156000.0 True False 12575729.292933727 10483605.630779816 9105154.54323107 1.0 0.8336379852475458 0.7240259655038245 23.584138731581515 -8.837407428825426 0.0548788837896802 1.76083974052654 4.621386319725658e-09 0.9999970930325682 0.0001933563970739541 0.351993968363989 0.016087630377803155 0.272874946641965 0.2367599714304606 1.4540942971485403e-09 8.837407428825426 -1.7608397359051535 NK(ub)LDHYAIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKLDHYAIIK 10 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9 P62750 RPL23A 60S ribosomal protein L23a 1 36460400.0 12057000.0 9321400.0 15082000.0 True False 11674257.134668114 13043483.630458832 11131571.749698471 1.0 1.1172859634661152 0.9535143539576431 23.47682741438389 -6.714431069763615 1.779085145150307 1.0717738714774325 0.9538407681431408 0.4862897196854672 0.04939070631523778 0.3662257923527777 2.262126598308356 0.02206890631842725 0.05577299825042533 1.9300516453057647e-07 6.714431069763615 -0.11793310333429174 NK(ub)LDHYAIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKLDHYAIIK 10 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9 P62750 RPL23A 60S ribosomal protein L23a 1 37588000.0 11392000.0 12029000.0 14167000.0 True False 17282496.86675807 9882330.966994027 11366886.240383318 1.0 0.5718115295019752 0.6577108810155143 24.042808328302282 -10.124584521378567 5.418752524787596 1.0000069513630159 0.6147612052586184 0.9640514620334992 0.0350682634078399 2.94501511603683e-06 4.7584528313691086e-07 0.03395531200183575 0.011318233346511646 7.50611957556414e-11 10.124584521378567 -0.38524574610439744 NK(ub)LDHYAIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKLDHYAIIK 10 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9 P62750 RPL23A 60S ribosomal protein L23a 1 25924100.0 9592400.0 7884600.0 8447100.0 True False 13138969.504862923 7536232.301114497 6452068.95348535 1.0 0.5735786431595893 0.4910635458204957 23.647348793104406 -13.999999999999993 0.2309321250962518 3.7035360237104396 0.45129816866696587 0.9995110806263022 0.004931412453306338 13.320451494794982 0.15215092542850986 16.521141499601303 0.04258562045393996 1.0000000000000164e-14 13.999999999999993 -3.252237855043474 NK(ub)LDHYAIIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKLDHYAIIK 10 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9 P62750 RPL23A 60S ribosomal protein L23a 1 31188900.0 12057000.0 11299000.0 7832900.0 True False 10025929.715665033 11238130.044324104 9470723.174762383 1.0 1.1209065256826074 0.9446229370593765 23.257232689818167 -6.722092292969018 1.7515796867888873 1.0733923993269072 0.9448610113609467 0.5224554138880844 0.05086530005571915 0.3512736128252277 2.107273362881799 0.023046906967724115 0.05771899274617006 1.8963028904819845e-07 6.722092292969018 -0.12853138796596053 NK(ub)LDHYAIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKLDHYAIIK 10 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9 P62750 RPL23A 60S ribosomal protein L23a 1 31703200.0 11392000.0 12280000.0 8031200.0 True False 14747168.569891809 11596607.205012446 6569604.007070882 1.0 0.7863616090134328 0.4454823972436005 23.81393465039473 -6.964210230757068 0.3713577916479267 1.0258136534402373 0.19413951333945997 0.9998959269790687 0.002329622456308568 0.07822999827544193 0.01581122475675442 0.0044839851795954 0.0289297044726417 1.0858998402638546e-07 6.964210230757068 -0.8316741401007773 down NK(ub)LQCSDTEQVEADLE ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKLQCSDTEQVEADLE 16 1 P08910 P08910 ABHD2 Abhydrolase domain-containing protein 2 1 7301360.0 832460.0 0.0 6468900.0 True False 1091363.1215541072 0.0 5799560.282070446 1.0 0.0 5.314051911349029 20.057699768605573 -6.858026968147185 1.1955693735447903 0.4599877716559666 5.561969008472472 0.9512041036213349 0.5093452214179169 0.14885238896685532 0.4054115734174404 0.3325217353879667 0.7746102684151375 1.3866697189263641e-07 6.858026968147185 5.101981236816505 up NK(ub)LQCSDTEQVEADLE ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKLQCSDTEQVEADLE 16 1 P08910 P08910 ABHD2 Abhydrolase domain-containing protein 2 1 14469960.0 832460.0 1439500.0 12198000.0 True False 1140242.9583856177 1375898.1302100716 9317083.625695724 1.0 1.206671016989309 8.171138928923591 20.120909830128465 -6.9132396958270546 0.873388983442898 0.8058282897621994 9.136431477961944 0.992087663380802 0.29646251687503516 0.10231429237194803 0.12743733149177625 0.24667494149242014 0.6972278091751574 1.2211255105051918e-07 6.9132396958270546 8.330603188199744 up NK(ub)NEVFYQCPDQMAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKNEVFYQCPDQMAR 15 1 E9PJM3;Q9UK99-3;Q9UK99-2;Q9UK99;G3V1E0 E9PJM3 FBXO3 F-box only protein 3 1 21639900.0 1882700.0 3526200.0 16231000.0 True False 2856193.5438066516 2896922.059673649 13022935.735699981 1.0 1.0142597184827733 4.559542459557342 21.44566231312722 -6.907780652120749 0.910698307308099 0.8823782571197073 4.996635153696744 0.9900571736134771 0.16698393725677255 0.10590445261513294 0.1468567477345655 0.1352291918973942 0.3678035845801539 1.2365718275680602e-07 6.907780652120749 4.114256896577037 up NK(ub)NGPALGGLSCSPNLPGQTTVQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKNGPALGGLSCSPNLPGQTTVQVR 25 1 M9T4I7;Q5U5Q3 M9T4I7 MEX3C RNA-binding E3 ubiquitin-protein ligase MEX3C 1 9605700.0 4879800.0 3445800.0 1280100.0 True False 4057769.9117941703 3427236.79146225 1547762.991486334 1.0 0.8446109232316906 0.38143192569585105 21.95225563143093 -6.951595185683134 0.5410482455146279 1.006772566107215 0.19784222325970766 0.9993205916763007 0.006848526649172672 0.08285146064706427 0.03335989588237083 0.007521804177274505 0.03836424546618988 1.1179047830359517e-07 6.951595185683134 -0.8089303428475074 down NK(ub)NLPPEEQMISALPDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKNLPPEEQMISALPDIK 18 1 O15355 O15355 PPM1G Protein phosphatase 1G 1 8002500.0 1836100.0 2897900.0 3268500.0 True False 1777814.0105303274 4055046.5823488557 2412381.797101809 1.0 2.2809172153723902 1.3569371052386905 20.761672971039218 -10.147217953359776 4.680105474712422 0.9999164136629589 1.8189271603142552 0.5115707503028015 0.37721330041454915 263800597.1808115 38.57445511929646 237620.09418857432 0.1291301460130314 7.124953701986047e-11 10.147217953359776 0.8190107466512963 NK(ub)NLPPEEQMISALPDIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKNLPPEEQMISALPDIK 18 1 O15355 O15355 PPM1G Protein phosphatase 1G 1 6349800.0 1836100.0 2398700.0 2115000.0 True False 1526798.5030216968 2385777.7269953294 2557236.721344894 1.0 1.562601562860863 1.6749012500888951 20.542078246473494 -11.526405018509445 0.2794378140894118 8.689035275501437e-12 1.7135689224029762 0.999340654533827 0.007581685573003554 3.98563119797764 0.15218090086900313 2.4427398461304466 0.04442305445259153 2.975739990876651e-12 11.526405018509445 1.7135689223942872 NK(ub)NRPEPHSDENGSTTPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKNRPEPHSDENGSTTPK 18 2 Q03701;C9J9W7 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 1 1366230.0 332190.0 647070.0 386970.0 True False 435504.306932536 550529.6782591051 346930.05647835025 1.0 1.2641199397928977 0.7966168209034341 18.732327460906156 -6.753427014867342 1.6371873928832759 1.1546614580433783 0.7954398331258993 0.6635965856013277 0.1110087898424504 0.29409358392320956 1.5519417616447464 0.053540370083520125 0.1295160304496984 1.7643022384563694e-07 6.753427014867342 -0.359221624917479 NK(ub)NRPEPHSDENGSTTPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKNRPEPHSDENGSTTPK 18 2 Q03701;C9J9W7 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 1 1752520.0 332190.0 694760.0 725570.0 True False 455009.62009720394 664063.205935914 554205.3095832143 1.0 1.4594487162580205 1.2180078950085038 18.795537522429047 -10.117195010258175 4.40256871161626 0.9999598574235637 1.3387283056109003 0.7240877944851514 0.09856780261421039 68728518.5167256 3.44236771880144 30640.5743108069 0.033742380570934476 7.634928771353447e-11 10.117195010258175 0.33876844818733653 NK(ub)QTYSTEPNNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKQTYSTEPNNLK 13 1 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 1 7510000.0 1415100.0 1153000.0 4941900.0 True False 1855209.8038478945 980976.8943587996 4430559.594052153 1.0 0.5287687097837416 2.3881717231456623 20.82315091835635 -6.839541194059556 1.284682008577999 0.7493124382946783 2.448714183532922 0.9236362361623046 0.2181055626600771 0.16933718787429308 0.5431074118749605 0.13314097380843873 0.30666732893481463 1.4469675976176292e-07 6.839541194059556 1.6994017452382437 up NK(ub)QTYSTEPNNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKQTYSTEPNNLK 13 1 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 1 3900680.0 1415100.0 908080.0 1577500.0 True False 1938300.711639585 867958.0229810091 1204926.9896323176 1.0 0.44779327468069385 0.6216408952422477 20.886360979879242 -10.384260462856476 5.281384414785323 1.000260471319866 0.5347170849614582 0.90521960628336 0.07097299389551329 0.000217791649674582 2.5391616092977363e-05 0.06875707758067363 0.022906435282309952 4.1279985602135835e-11 10.384260462856476 -0.46554338635840775 NK(ub)SAFPFSDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKSAFPFSDK 10 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 41097500.0 25520000.0 9941800.0 5635700.0 True False 33456967.13603157 8458522.192832867 5052571.825451682 1.0 0.2528179604099093 0.15101703047107046 24.995803335645192 -13.999999999999998 0.28087596939944365 7.118945158279467 0.12063418448544837 0.9996071180041297 0.007502505010760248 15.445876735196595 0.16789953146270056 54.31886914031672 0.040103096391608764 1.0000000000000041e-14 13.999999999999998 -6.998310973794019 NK(ub)SAFPFSDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKSAFPFSDK 10 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 53106500.0 37717000.0 8224800.0 7164700.0 True False 36519694.48024199 11509005.531765385 5288050.133607259 1.0 0.31514517565288025 0.14479995544508778 25.1221713601557 -13.999999999999684 0.19540225695879687 4.742360526255244 0.029019789915169816 0.99948733425344 0.008368435904279862 12.443721320029528 0.14017866550737174 17.76551859599906 0.1123066169614305 1.0000000000007281e-14 13.999999999999684 -4.713340736340075 NK(ub)SAFPFSDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKSAFPFSDK 10 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 46877500.0 25520000.0 14215700.0 7141800.0 True False 34955433.652068555 13587603.36896653 5455053.929988015 1.0 0.3887121957693824 0.1560573953762179 25.059013397168084 -10.322402942983613 0.22182940439067322 1.7067847700077674 3.684582803110096e-22 0.999261245022693 0.009673618417204866 1.937339267653687 0.10868121524183104 0.9044371151949698 0.12176767926709231 4.75989154130004e-11 10.322402942983613 -1.7067847700077674 NK(ub)SAFPFSDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKSAFPFSDK 10 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 64334700.0 37717000.0 21855000.0 4762700.0 True False 31363356.64640777 21737262.77712214 5758558.549763273 1.0 0.6930783277500955 0.18360785214049577 24.902576635589977 -7.2794239393541815 0.47330978353202324 1.0152133242875085 6.562784805546717e-19 0.9989692059552082 0.010809845123082654 0.09803297509549086 0.041311678313234006 0.012862270189585641 0.053440938314700634 5.255040417845078e-08 7.2794239393541815 -1.0152133242875085 down NK(ub)SELLPTVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKSELLPTVR 10 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 8348900.0 1938900.0 3714100.0 2695900.0 True False 2541916.6763343066 3159970.7574484088 2416954.1288988455 1.0 1.2431449019821519 0.9508392432376386 21.27748530910469 -6.685947919565296 1.8810334547941256 1.1530161470022504 0.9519028802367839 0.35138325807542425 0.10292010074025278 0.4254647144851229 2.9155114260335555 0.04382561821462883 0.11470207193359185 2.0608770380693549e-07 6.685947919565296 -0.20111326676546648 NK(ub)SELLPTVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKSELLPTVR 10 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 6364800.0 1758600.0 1713300.0 2892900.0 True False 1702774.205608973 2397429.624741466 2135162.7048602765 1.0 1.4079550987114342 1.2539317883880359 20.699455710127328 -10.137000757430291 5.216247095234537 0.9999895735494186 1.3309434435500107 0.8602501453086977 0.06287975313207532 7.624705454187104e-06 1.261373127598053e-06 0.060884976136496065 0.020294353057708134 7.294562380469866e-11 10.137000757430291 0.33095387000059207 NK(ub)SELLPTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKSELLPTVR 10 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 17335100.0 3043400.0 3308700.0 10983000.0 True False 4617060.302343001 2718236.6340089096 8812205.235980092 1.0 0.5887375204152082 1.9086181810335459 22.138543144536463 -6.8229888360233435 1.3588958955877095 0.7789788100476978 1.9393221160871905 0.8911231093276516 0.18195702500293878 0.18962295438755733 0.6872096624523173 0.10520030257058073 0.2422978614826771 1.5031806063634053e-07 6.8229888360233435 1.1603433060394928 NK(ub)SELLPTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKSELLPTVR 10 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 7915600.0 1938900.0 2391900.0 3584800.0 True False 2655763.7268023356 2286217.9490444367 2738144.071273491 1.0 0.8608514100752294 1.031019455397994 21.340695370627582 -6.689296957450957 1.8685502724687026 0.9127086299334021 1.030432786644384 0.3673449431868212 0.05885794274577324 0.4181567560578042 2.830013622657333 0.025202118466845308 0.06569508540796445 2.045045817974571e-07 6.689296957450957 0.11772415671098202 NK(ub)SELLPTVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKSELLPTVR 10 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 5970200.0 1758600.0 2696300.0 1515300.0 True False 1462353.8191895636 2681774.4967263546 1832142.2240444063 1.0 1.8338752643410154 1.252872047791949 20.479860985561604 -9.80817250178773 5.892902076592298 0.9999999485159722 1.5433736560678637 0.5383654186214557 0.23719356991506702 1.601523607614597e-07 3.2521274395013496e-08 0.22966171048045075 0.07655389550832793 1.5553477247107183e-10 9.80817250178773 0.5433737075518915 NK(ub)SELLPTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKSELLPTVR 10 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 13190100.0 3043400.0 2662000.0 7484700.0 True False 3939741.294382786 2513857.359913934 6122561.399507349 1.0 0.6380767598872921 1.5540516348717592 21.909669466628912 -6.799517239473504 1.4580105080102783 0.8001911031325195 1.5665284827090218 0.8307225154848654 0.15497761234318264 0.22144170295942714 0.9294257208214332 0.08362556737653473 0.1945286573272651 1.586655934831373e-07 6.799517239473504 0.7663373795765023 NK(ub)SFGSAQEFAWAHDSSEYAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKSFGSAQEFAWAHDSSEYAIR 22 1 P35606-2;P35606;H0Y938 P35606-2 COPB2 Coatomer subunit beta 1 6336600.0 2313200.0 1818400.0 2205000.0 True False 2239768.732181665 2544496.6028307304 1627444.351417925 1.0 1.1360532747290577 0.7266126756902708 21.09491834350012 -6.817133265389277 1.384247649867288 1.0735507391098982 0.7182129382670641 0.8776618600796482 0.05955122039241744 0.19723108843642778 0.7433609172482278 0.03381345253249318 0.0779998209975225 1.523585162488829e-07 6.817133265389277 -0.35533780084283406 NK(ub)SFGSAQEFAWAHDSSEYAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKSFGSAQEFAWAHDSSEYAIR 22 1 P35606-2;P35606;H0Y938 P35606-2 COPB2 Coatomer subunit beta 1 22902800.0 4836200.0 6970600.0 11096000.0 True False 7336868.973579303 5726641.968453613 8902870.736450432 1.0 0.7805294041744161 1.2134427871767146 22.806733090158595 -6.7688608531057435 1.5786369276872032 0.8739373334742802 1.21578471614236 0.7262726648936856 0.09246949867538524 0.26826252678469437 1.3191772840909957 0.046173959664013754 0.11003638709991713 1.702703963211882e-07 6.7688608531057435 0.3418473826680799 NK(ub)STESLQANVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKSTESLQANVQR 13 1 P26373;J3QSB4 P26373 RPL13 60S ribosomal protein L13 1 8411260.0 1925300.0 2867880.0 3618080.0 True False 2524086.9446317228 2440003.482908686 3243715.788674036 1.0 0.9666875731432838 1.285104617958123 21.267330175535538 -6.881058753649293 1.073837474536046 0.9790478382962827 1.3081374392707765 0.9745311127699197 0.022805379379623358 0.1266981486703616 0.2666326618175299 0.016343206986193515 0.03963184280101513 1.3150469136716208e-07 6.881058753649293 0.3290896009744938 NK(ub)STESLQANVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKSTESLQANVQR 13 1 P26373;J3QSB4 P26373 RPL13 60S ribosomal protein L13 1 13861080.0 3187270.0 3817510.0 6856300.0 True False 3086091.8584733917 5341861.651051655 5060429.345408937 1.0 1.7309470670436018 1.6397533117864476 21.557349574133568 -10.123026028502503 4.215854724166517 0.9998675477761243 1.6853501894447096 0.9868949900869501 0.03722969511847658 26179498.839171965 54240565.98159757 49838.949394877396 0.013624671640363833 7.533104143468337e-11 10.123026028502503 0.6854826416685853 NK(ub)STESLQANVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKSTESLQANVQR 13 1 P26373;J3QSB4 P26373 RPL13 60S ribosomal protein L13 1 20208000.0 2221800.0 2977300.0 15008900.0 True False 3370633.0353373485 2445977.553248925 12042384.336365452 1.0 0.7256730494258983 3.5727366966722305 21.684588137341308 -6.883253741622477 1.061451444036621 0.8213830268032668 3.787560181964544 0.976218030962996 0.19775775316318392 0.1247884733648541 0.2551821573481948 0.14306792281416503 0.34903058641052737 1.3084172415818463e-07 6.883253741622477 2.9661771551612772 up NK(ub)STESLQANVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKSTESLQANVQR 13 1 P26373;J3QSB4 P26373 RPL13 60S ribosomal protein L13 1 7081130.0 1925300.0 1211200.0 3944630.0 True False 2637135.439276159 1157685.1790972138 3012989.636204966 1.0 0.43899344791141076 1.142523660837068 21.33054023705843 -6.694308754735029 1.851182438385633 0.6497106047436564 1.140220340513388 0.39060929899806607 0.23706349563784504 0.4074838435050022 2.7106081781620346 0.10232312654779278 0.2650109243631194 2.021581456583155e-07 6.694308754735029 0.49050973576973156 NK(ub)STESLQANVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKSTESLQANVQR 13 1 P26373;J3QSB4 P26373 RPL13 60S ribosomal protein L13 1 15364470.0 3187270.0 8671100.0 3506100.0 True False 2650356.2250018856 8624387.063221399 4239209.299625222 1.0 3.2540482603297085 1.5994866122655667 21.337754849567844 -6.566732855665048 2.3193489009472383 2.546990472296858 1.602634968456864 0.0 0.9825026721199095 0.74015316075011 7.469907221143643 0.35873322862400114 1.1026506983938744 2.7118592447551563e-07 6.566732855665048 -0.9443555038399942 NK(ub)STESLQANVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKSTESLQANVQR 13 1 P26373;J3QSB4 P26373 RPL13 60S ribosomal protein L13 1 6856910.0 2221800.0 4635110.0 0.0 True False 2876163.898225563 4377162.053910846 0.0 1.0 1.5218750421738194 0.0 21.455714459433757 -6.833797328738013 1.4438904699004278 1.281704774391312 5.404215513251318e-23 0.8696701611333111 0.227957854016171 0.19074898074910926 0.7979081881894745 0.12642186498736152 0.2726258366659131 1.4662319245891672e-07 6.833797328738013 -1.281704774391312 down NK(ub)TEDLEATSEHFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKTEDLEATSEHFK 14 1 Q9BV40;C9JXZ5 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 66906000.0 34437000.0 21043000.0 11426000.0 True False 45147240.48838244 17903466.424971536 10243747.125931293 1.0 0.3965572697533654 0.22689641748020628 25.428134473503675 -13.999999999999998 0.17799149974787176 4.112054774475847 0.08929410367451925 0.9995006982116367 0.007413325698199883 12.1794121552877 0.13372229327227414 13.102538059982452 0.12887079426547926 1.0000000000000041e-14 13.999999999999998 -4.022760670801327 NK(ub)TEDLEATSEHFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKTEDLEATSEHFK 14 1 Q9BV40;C9JXZ5 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 52355000.0 18086000.0 15562000.0 18707000.0 True False 17511869.829775866 21775987.754757933 13807075.502029523 1.0 1.24349872209144 0.7884409624010001 24.06182979996028 -6.761384480604527 1.6075455217982988 1.1411982682766948 0.7866812510835003 0.6964599052300589 0.1024366158547956 0.2806108764632513 1.4295628214478497 0.05027281038358092 0.12063505145564295 1.7322697415120015e-07 6.761384480604527 -0.3545170171931945 NK(ub)TEDLEATSEHFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKTEDLEATSEHFK 14 1 Q9BV40;C9JXZ5 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 132538000.0 41238000.0 47697000.0 43603000.0 True False 62561060.901629984 39185097.69163802 34984847.938126214 1.0 0.6263496354905497 0.5592112319376398 25.89876164208287 -13.999999999999998 0.24143702154554023 3.4905412315898654 0.5299283074373222 0.9995273667580397 0.00421566886564074 13.674532794611402 0.15550964193301173 16.43379975750515 0.032531504486276196 1.0000000000000041e-14 13.999999999999998 -2.960612924152543 NK(ub)TEDLEATSEHFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKTEDLEATSEHFK 14 1 Q9BV40;C9JXZ5 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 65084000.0 34437000.0 16259000.0 14388000.0 True False 47169289.52493281 15540623.618676988 10989850.730161523 1.0 0.3294648652798237 0.23298741280282573 25.491344535026567 -13.999999999999998 0.2730729967317233 6.261896232928034 0.2019048185687441 0.9995899724413176 0.006907277370898837 15.035960454750647 0.16545149627571873 44.002914062627376 0.03946317253285656 1.0000000000000041e-14 13.999999999999998 -6.05999141435929 NK(ub)TEDLEATSEHFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKTEDLEATSEHFK 14 1 Q9BV40;C9JXZ5 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 55408000.0 18086000.0 26589000.0 10733000.0 True False 15039310.345651317 26445759.779496722 12977220.676215013 1.0 1.7584423202719286 0.8628866868198802 23.842235075394555 -6.6822952630749874 1.8941776058356259 1.4788876717200394 0.866265724914679 0.3345375246026522 0.32128596134842785 0.4333999970604029 3.0085051341436477 0.13601935492312706 0.3576320641715251 2.078283247668997e-07 6.6822952630749874 -0.6126219468053604 NK(ub)TEDLEATSEHFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKTEDLEATSEHFK 14 1 Q9BV40;C9JXZ5 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 124082000.0 41238000.0 36098000.0 46746000.0 True False 53383403.92250685 34089114.56730776 38238707.65446449 1.0 0.6385713922775077 0.716303286129395 25.66988796417532 -9.915244591964305 5.410751091002506 1.000000435785309 0.6774373392018277 0.9582634530577991 0.03173391278526131 1.668380413574669e-07 3.3424898054242796e-08 0.030726270593389973 0.01024207630978335 1.2155012450610857e-10 9.915244591964305 -0.32256309658348126 NK(ub)TGEITASSNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKTGEITASSNK 12 1 Q8TAT6;Q8TAT6-2;A0A0D9SFI9;I3L4U9 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 1625420.0 394220.0 723640.0 507560.0 True False 516826.23763191083 615675.7327266266 455042.5600593108 1.0 1.1912625325440953 0.8804556094990614 18.979319787387748 -6.740184311424104 1.686067797474811 1.1137681717404968 0.8802645743026392 0.6059078220056824 0.08035893026449047 0.3174031542495885 1.7717946260653776 0.0377040756034629 0.09250204345082459 1.8189287546302172e-07 6.740184311424104 -0.23350359743785765 NK(ub)TGEITASSNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKTGEITASSNK 12 1 Q8TAT6;Q8TAT6-2;A0A0D9SFI9;I3L4U9 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 3043140.0 821040.0 924000.0 1298100.0 True False 794976.5346145736 1292958.0185963449 958088.6678347421 1.0 1.6264102930072097 1.2051785507093613 19.60055275131832 -10.07203662468267 4.715875675405992 0.9999825130243829 1.415794421866661 0.5650535812510463 0.17196713871094232 3.1619091245757705e-05 6.22195014751067e-06 0.16651346191879798 0.05550215535613116 8.471559692382458e-11 10.07203662468267 0.41581190884227803 NK(ub)TGEITASSNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKTGEITASSNK 12 1 Q8TAT6;Q8TAT6-2;A0A0D9SFI9;I3L4U9 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 1971370.0 394220.0 612210.0 964940.0 True False 539973.7873949241 585160.5378922588 737041.0455631121 1.0 1.0836832297273835 1.364957082674196 19.04252984891064 -6.9488719144956725 0.571103056073137 0.9965134017197793 1.4658279498359106 0.9991096882222521 0.004657793269871832 0.0839421031543517 0.03786302300406072 0.0049284626576350625 0.02344197272343843 1.1249367001225066e-07 6.9488719144956725 0.46931454811613127 NK(ub)TGEITASSNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKTGEITASSNK 12 1 Q8TAT6;Q8TAT6-2;A0A0D9SFI9;I3L4U9 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 2625490.0 821040.0 1147700.0 656750.0 True False 682731.138239166 1141517.1122993876 794073.3885310923 1.0 1.6719863037790805 1.1630835977088865 19.380958026752598 -10.043764502520526 4.841947356409412 0.9999908897866641 1.4175349507472734 0.47300250253914233 0.2077586597876263 2.195037138539776e-05 4.334981830066241e-06 0.2011661700949863 0.06705381911251473 9.041396132252251e-11 10.043764502520526 0.41754406096060936 NK(ub)TGLVSSTWDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKTGLVSSTWDR 12 1 Q9UKG1 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 1 1697100.0 0.0 0.0 1697100.0 True False 0.0 0.0 2051955.7634961791 0.0 NK(ub)TPVQDCPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKTPVQDCPR 10 1 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4 A3QJZ7 LOC101929983;PRAMEF25;PRAMEF6 PRAME family member 6 1 23678300.0 4990300.0 7643000.0 11045000.0 True False 6542331.62613395 6502694.192180661 9902169.351121238 1.0 0.9939413902843209 1.5135535642317646 22.641373459783217 -6.904264342866986 0.9339314486430036 0.9808503155550653 1.5730726152668912 0.9885704594466824 0.026035775591012784 0.10833401902770996 0.16025332421233357 0.020728866623463064 0.05518249441867204 1.246624497912623e-07 6.904264342866986 0.5922222997118259 NK(ub)TPVQDCPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKTPVQDCPR 10 1 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4 A3QJZ7 LOC101929983;PRAMEF25;PRAMEF6 PRAME family member 6 1 12857400.0 3796100.0 3791200.0 5270100.0 True False 3675594.883380084 5305045.930846825 3889702.710388941 1.0 1.4433162791782688 1.0582512039008944 21.80954633378944 -10.349852125523663 6.198003493214931 0.9999765749471479 1.2507837415395817 0.3612459019909864 0.15720215869932708 5.0889977712478395e-05 5.338262876613647e-06 0.15222453637731656 0.05073677855252905 4.4683571093587784e-11 10.349852125523663 0.25080716659243385 NK(ub)TPVQDCPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKTPVQDCPR 10 1 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4 A3QJZ7 LOC101929983;PRAMEF25;PRAMEF6 PRAME family member 6 1 31150100.0 5451800.0 4372300.0 21326000.0 True False 8270779.179967656 3592028.904064177 17110906.752482146 1.0 0.434303567524121 2.068838543522699 22.979591819654544 -6.813246327687123 1.4008267263524352 0.6928582130032827 2.099610797000197 0.8681316231633418 0.2461168176582553 0.20241190118850466 0.7821961449424844 0.1381237538788604 0.31906746251527834 1.537282461033757e-07 6.813246327687123 1.4067525839969144 up NK(ub)TPVQDCPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKTPVQDCPR 10 1 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4 A3QJZ7 LOC101929983;PRAMEF25;PRAMEF6 PRAME family member 6 1 27268900.0 4990300.0 7526600.0 14752000.0 True False 6835348.767786746 7194049.924862196 11267881.426976837 1.0 1.0524773744927132 1.648472054575984 22.70458352130611 -6.9242028435172465 0.7929247806192378 0.9887330101398965 1.7545328998770744 0.9952711779130751 0.020224547625962278 0.09576139987078297 0.09325671309787527 0.017825380262280408 0.05574448079530426 1.190685751137355e-07 6.9242028435172465 0.7657998897371779 NK(ub)TPVQDCPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKTPVQDCPR 10 1 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4 A3QJZ7 LOC101929983;PRAMEF25;PRAMEF6 PRAME family member 6 1 14883600.0 3796100.0 3353900.0 7733600.0 True False 3156625.345744055 3335831.875002972 9350660.00387371 1.0 1.056771554945706 2.9622330747869112 21.589951609223718 -6.913262494714921 0.8732110616380122 0.9469147316842828 3.2264826128313095 0.9920958577479687 0.08107437417234263 0.10230026273267365 0.12735310302259395 0.0674664937415841 0.19073258236952284 1.2210614075197748e-07 6.913262494714921 2.2795678811470266 up NK(ub)TPVQDCPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKTPVQDCPR 10 1 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4 A3QJZ7 LOC101929983;PRAMEF25;PRAMEF6 PRAME family member 6 1 20411200.0 5451800.0 3520400.0 11439000.0 True False 7057462.571044248 3324486.6453196886 9357219.374051686 1.0 0.4710597628897925 1.3258617073568353 22.750718141746994 -6.739330461272818 1.6891813149903268 0.6850376304724413 1.3262864517706734 0.6019139629094725 0.22224180263895013 0.3190312951797925 1.7871342671378418 0.10409487817023615 0.25562412037602444 1.822508400231989e-07 6.739330461272818 0.6412488212982321 NK(ub)VDTYVEFPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKVDTYVEFPLR 12 1 Q6JHV3;H0YMI4;Q9Y6I4;H0YLB7;H0YKU8;Q9Y6I4-2;H0YM72 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 1 57032700.0 20949300.0 19600800.0 16482600.0 True False 27464735.173309773 16676437.04331998 14777138.664263519 1.0 0.6071945328468391 0.5380404570084455 24.711077045054118 -13.999999999999998 0.24433368660149773 3.655672901205343 0.5086964865361943 0.9995323684973487 0.004399311049435837 13.780405717259775 0.15642836225889417 17.901374890788897 0.0329518030132144 1.0000000000000041e-14 13.999999999999998 -3.1469764146691483 NK(ub)VDTYVEFPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKVDTYVEFPLR 12 1 Q6JHV3;H0YMI4;Q9Y6I4;H0YLB7;H0YKU8;Q9Y6I4-2;H0YM72 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 1 89240700.0 26709700.0 22954000.0 39577000.0 True False 25861815.193650614 32119651.903528683 29210596.415449973 1.0 1.241972060469075 1.1294874778403614 24.624320203047734 -10.40780277247996 5.139029069339721 0.9998319019204165 1.1857297691547273 0.7842546916301156 0.04592163856174553 8.852253871298917e-05 1.0201011418577842e-05 0.04450350127128245 0.014821145115011775 3.910184299076209e-11 10.40780277247996 0.1858978672343108 NK(ub)VDTYVEFPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKVDTYVEFPLR 12 1 Q6JHV3;H0YMI4;Q9Y6I4;H0YLB7;H0YKU8;Q9Y6I4-2;H0YM72 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 1 113646000.0 46596000.0 13387000.0 53663000.0 True False 70689538.62389907 10997985.256891612 43056484.52867153 1.0 0.15558151136628523 0.6090927365893825 26.074993389965517 -10.860853952276997 12.151605635778315 1.0125864600466377 0.3823371239778339 0.7120841062420578 0.1851451824035014 0.05731131653947737 0.000656261133293298 0.162737065673417 0.05975535067327462 1.3776726848438006e-11 10.860853952276997 -0.6302493360688037 NK(ub)VDTYVEFPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKVDTYVEFPLR 12 1 Q6JHV3;H0YMI4;Q9Y6I4;H0YLB7;H0YKU8;Q9Y6I4-2;H0YM72 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 1 58814100.0 20949300.0 16914200.0 20950600.0 True False 28694822.343545415 16166874.716220351 16002499.771151086 1.0 0.5634073813966969 0.5576789979586918 24.77428710657701 NK(ub)VDTYVEFPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKVDTYVEFPLR 12 1 Q6JHV3;H0YMI4;Q9Y6I4;H0YLB7;H0YKU8;Q9Y6I4-2;H0YM72 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 1 81209500.0 26709700.0 35257000.0 19242800.0 True False 22210298.99033747 35067063.543033466 23266380.51134542 1.0 1.57886499224028 1.0475491807412136 24.40472547848201 -10.192948013706639 4.008774166973908 0.9998307494690378 1.313207086078813 0.3166301290916276 0.2169087720765557 29558759.817909632 25052693.891491804 41227.435269115456 0.07425364308270126 6.41286335802046e-11 10.192948013706639 0.31337633660977515 NK(ub)VDTYVEFPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKVDTYVEFPLR 12 1 Q6JHV3;H0YMI4;Q9Y6I4;H0YLB7;H0YKU8;Q9Y6I4-2;H0YM72 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 1 139977000.0 46596000.0 44019000.0 49362000.0 True False 60319440.54447666 41569303.95418919 40378622.49689127 1.0 0.6891526774612238 0.6694130803006704 25.846119712057966 -13.999999999999998 0.39195639346284633 5.976609390427544 0.6680302380347194 0.9998260778073123 0.0019966762217132577 25.619506409242128 0.20543208115579917 108.10067962241853 0.005166393652720802 1.0000000000000041e-14 13.999999999999998 -5.308579152392825 NK(ub)VETFSESR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKVETFSESR 10 1 D6RC76;D6RHD3;Q9BS16 D6RC76 CENPK Centromere protein K 1 9541000.0 1582000.0 2955800.0 5003200.0 True False 2047930.185882095 2791307.131642981 4092668.9371671826 1.0 1.3629893982155914 1.9984416292024951 20.965735103901125 -6.962563348599391 0.39766115956039905 0.964154404798441 2.4203919797642617 0.9998537743850043 0.004989796656398431 0.07879783995009053 0.017838787194013765 0.008179745228144646 0.053287677650308236 1.0900254836320004e-07 6.962563348599391 1.4562375749658207 NK(ub)VSHIDVITAEMAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKVSHIDVITAEMAK 15 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 33090200.0 18359000.0 11525000.0 3206200.0 True False 24068826.788808886 9805514.924098136 2874453.1800420885 1.0 0.40739480200411504 0.11942639353649771 24.520662484992855 -8.933184368992398 0.30521944881953644 1.2330794363117008 6.207103643402809e-17 0.9985465864152643 0.013975882241388965 0.41994783559716464 0.1039344343314625 0.2054734296408243 0.09338107318092785 1.1663143819931576e-09 8.933184368992398 -1.2330794363117008 NK(ub)VSHIDVITAEMAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKVSHIDVITAEMAK 15 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 33781700.0 13266000.0 14006000.0 6509700.0 True False 12844878.091441255 19598668.840325117 4804614.2831860585 1.0 1.525796407003973 0.3740490372102051 23.614689862141372 -6.782580702388065 1.5257549127530896 1.2967247134400934 0.364168834497498 0.7764190786471141 0.22261049199903232 0.2465947777029848 1.1340000577504712 0.11489475203190741 0.2705314291773346 1.649754408680795e-07 6.782580702388065 -0.9325558789425954 down NK(ub)VSHIDVITAEMAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKVSHIDVITAEMAK 15 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 63688500.0 33561000.0 21497000.0 8630500.0 True False 50914490.637751654 17660692.393172402 6924677.892117475 1.0 0.3468696666107369 0.13600603296584926 25.601572980551836 -11.241189141391947 0.21427887670062806 2.1257574755270974 6.828230017326223e-19 0.999320462608234 0.009587930443058345 3.5387380736264853 0.12243210705024113 2.021678589629233 0.11856233931114005 5.738664808037078e-12 11.241189141391947 -2.1257574755270974 NK(ub)VSHIDVITAEMAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKVSHIDVITAEMAK 15 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 41815400.0 18359000.0 16216000.0 7240400.0 True False 25146818.433319975 15499523.500858994 5530366.640718748 1.0 0.6163612125310395 0.21992311494128877 24.583872546515746 -7.561777795696367 0.3523246980446542 1.0601343097797378 6.488585784452938e-11 0.9992753634789239 0.00857316693533516 0.12306947788417587 0.04355165438636211 0.023173698431144415 0.06940428636702585 2.7429772416787053e-08 7.561777795696367 -1.060134309714852 down NK(ub)VSHIDVITAEMAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKVSHIDVITAEMAK 15 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 34002200.0 13266000.0 19017000.0 1719200.0 True False 11031266.783446327 18914551.646421045 2078676.7713173246 1.0 1.714630968295 0.1884350013578328 23.395095137575648 -6.779350721001659 1.5382462993057124 1.4049676472396122 0.1765462219660627 0.765182026420816 0.30212880721132107 0.2515579765349071 1.1756416141497577 0.15470129230399796 0.36525219091834243 1.6620698788765496e-07 6.779350721001659 -1.2284214252735495 NK(ub)VSHIDVITAEMAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKVSHIDVITAEMAK 15 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 66242000.0 33561000.0 27019000.0 5662000.0 True False 43445376.08621299 25515368.898390155 4631574.097026011 1.0 0.5872976872787904 0.1066068363140675 25.372699302644286 -7.667806604854398 0.47920811260419244 1.0219920720024067 7.998089506931347e-22 0.9965141700392385 0.021554545873487384 0.11734538902387665 0.08273214764806283 0.027577729530162094 0.07471201517607977 2.148787134886063e-08 7.667806604854398 -1.0219920720024067 down NK(ub)VSMAPDGNGGLYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKVSMAPDGNGGLYR 15 1 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 1 8906400.0 1784100.0 0.0 7122300.0 True False 2309552.6198686766 0.0 5826114.480969338 1.0 0.0 2.5226160386424175 21.13918198563833 -6.799159259501938 1.4594281969634704 0.4476627824470469 2.5566842295167507 0.8296625402930554 0.4280704752095999 0.22196525999927527 0.9334644481586587 0.23076218187532124 0.5369245710435293 1.5879643217119123e-07 6.799159259501938 2.1090214470697037 NK(ub)VTHILSVHDSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKVTHILSVHDSAR 14 1 Q9NRW4;Q9NRW4-2;S4R459 Q9NRW4 DUSP22 Dual specificity protein phosphatase 22 1 6652900.0 1410100.0 1414200.0 3828600.0 True False 1365337.1473497152 1978897.4349555722 2825774.804461981 1.0 1.4493837209343141 2.0696534990988504 20.380825814059218 -6.966602754313232 0.32938712290493544 0.9238893322115357 2.6154347042388606 0.9999424734276214 0.003326141095044383 0.07742120379455737 0.012964522764338772 0.009070582943159308 0.054128115101309875 1.0799340776556311e-07 6.966602754313232 1.691545372027325 NK(ub)VTHILSVHDSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKVTHILSVHDSAR 14 1 Q9NRW4;Q9NRW4-2;S4R459 Q9NRW4 DUSP22 Dual specificity protein phosphatase 22 1 6196900.0 1410100.0 2910700.0 1876100.0 True False 1172560.6280218358 2895019.4813712854 2268383.8358936943 1.0 2.4689721044576753 1.9345556909245394 20.161231089493494 -9.858012557828014 5.89780760819903 0.9999997789387777 2.2017638976926284 0.8708418475040107 0.21817458722613342 6.341616079499313e-07 1.2329102081342528e-07 0.2112466734926274 0.07041554524025136 1.3867157307584018e-10 9.858012557828014 1.2017641187538506 NK(ub)YECELQGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKYECELQGAK 11 1 E9PJF5;H0YCF7;G5E9I4;Q9HCU9 E9PJF5 BRMS1 Breast cancer metastasis-suppressor 1 1 10087400.0 0.0 2548500.0 7538900.0 True False 0.0 2093700.2634786156 6048833.110582744 0.0 NK(ub)YECELQGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKYECELQGAK 11 1 E9PJF5;H0YCF7;G5E9I4;Q9HCU9 E9PJF5 BRMS1 Breast cancer metastasis-suppressor 1 1 11061700.0 0.0 3275900.0 7785800.0 True False 0.0 3093593.2852524617 6368864.289054244 0.0 NK(ub)YQIHIPLPPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKYQIHIPLPPK 12 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 17239900.0 5359100.0 6718300.0 5162500.0 True False 7025831.9975982215 5715955.8277282845 4628334.022196769 1.0 0.8135628392028563 0.6587595638180593 22.744237648427905 -6.973261611609143 0.16235892206495264 1.1516993174573806 0.316506886948658 0.9999979317095732 0.0002005542598038666 0.07525788952646345 0.005023927610112763 0.007005934141710572 0.018417443059660032 1.0635021896012657e-07 6.973261611609143 -0.8351924305087226 NK(ub)YQIHIPLPPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKYQIHIPLPPK 12 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 22535100.0 4431200.0 9071500.0 9032400.0 True False 4290533.9815162495 12693797.257247549 6666543.473808284 1.0 2.9585588441748305 1.5537794369017832 22.03272577987995 -6.560033763320939 2.3454859793157494 2.349258706448267 1.5559303040460213 0.0 0.8551149291598251 0.7613740468676325 7.849131466039558 0.3100728470865675 0.9623552144229811 2.7540145898808547e-07 6.560033763320939 -0.7933284024022456 NK(ub)YQIHIPLPPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKYQIHIPLPPK 12 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 59267000.0 14876000.0 22498000.0 21893000.0 True False 22567979.58127572 18483056.122323688 17565838.953957215 1.0 0.8189947201857084 0.7783523062264422 24.427773929947872 -13.999999999999998 0.20988751923456422 2.0463342037826964 0.7543878290041169 0.9994899455432701 0.00217590038622249 12.744057812381808 0.1452102784105882 5.498626421102847 0.02409352247824835 1.0000000000000041e-14 13.999999999999998 -1.2919463747785795 NK(ub)YQIHIPLPPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKYQIHIPLPPK 12 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 18012500.0 5359100.0 5662600.0 6990800.0 True False 7340504.094231991 5412407.608285896 5339717.020045396 1.0 0.737334594301071 0.7274319244970151 22.807447709950797 NK(ub)YQIHIPLPPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKYQIHIPLPPK 12 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 18353200.0 4431200.0 8035000.0 5887000.0 True False 3684739.135444552 7991713.860177382 7117944.481587426 1.0 2.1688682879346373 1.9317363373482526 21.813131055314226 -10.161713864997848 4.452498360100628 0.9998088933795177 2.050302312671693 0.9631770240560829 0.09680871356238299 33899492.81134947 25.39103711677331 67586.24295145132 0.0331401975950149 6.891061645400929e-11 10.161713864997848 1.050493419292175 NK(ub)YQIHIPLPPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKYQIHIPLPPK 12 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 60732000.0 14876000.0 16444000.0 29412000.0 True False 19257275.249799028 15528876.944562273 24059317.792604934 1.0 0.8063901431083473 1.2493625126356347 24.19890025204032 -6.787922112498559 1.5048207740788362 0.8914998763526752 1.2537957950123488 0.7944774307870837 0.08220047984242862 0.23845403347649619 1.066800828392542 0.04300332405727096 0.10082737378122412 1.6295882610296927e-07 6.787922112498559 0.3622959186596736 NKDEK(ub)YNHIDESEMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKDEKYNHIDESEMK 15 2 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 2533790.0 712810.0 1014800.0 806180.0 True False 690182.2367224675 1420014.9321120908 595017.2731184139 1.0 2.057449259858451 0.8621161795528492 19.396617817925996 -6.673166851822129 1.9257395591612791 1.6730902974599329 0.8668262215985757 0.293382443792378 0.44885079207023604 0.4538515853302723 3.247681330955371 0.18742445511989045 0.4987666255454355 2.122428888287604e-07 6.673166851822129 -0.8062640758613572 NKDEK(ub)YNHIDESEMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKDEKYNHIDESEMK 15 2 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 2179870.0 838060.0 832380.0 509430.0 True False 1147913.4297199275 795602.6992874317 389113.12604018464 1.0 0.6930859755526564 0.3389742779950941 20.1305824141051 -7.110643366567158 0.29570577671430276 1.0706022804571682 1.0264739163405188e-15 0.9999563589620938 0.001784254053903193 0.07751078456560463 0.012555248644056624 0.00743334823128673 0.033414608846270184 7.750980306272271e-08 7.110643366567158 -1.070602280457167 down NKDEK(ub)YNHIDESEMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKDEKYNHIDESEMK 15 2 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 3550970.0 712810.0 2028800.0 809360.0 True False 592733.0978372069 2017870.4517147287 978593.433942176 1.0 3.404349207219289 1.6509849669487244 19.177023093360273 -6.564882690482028 2.3268799373159683 2.6519094979433664 1.654187475242385 0.0 1.04850559643706 0.7459834282350793 7.575440912052058 0.3820754496251259 1.1773888936331793 2.7234368502790035e-07 6.564882690482028 -0.9977220227009813 NKEEAAEYAK(ub)LLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKEEAAEYAKLLAK 14 2 P62753;A2A3R5 P62753 RPS6 40S ribosomal protein S6 1 15258800.0 5051600.0 5065500.0 5141700.0 True False 4891239.723106045 7088180.566233539 3794934.52230637 1.0 1.4491582845038697 0.7758635309529468 22.221768743233373 -6.726897487376611 1.7344857687399082 1.2712322283023816 0.7764823767315332 0.5448299201626672 0.18886628274699907 0.3420952763378754 2.014763446637741 0.08634060999950778 0.21500967544522168 1.8754371415816368e-07 6.726897487376611 -0.4947498515708484 NKEEAAEYAK(ub)LLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKEEAAEYAKLLAK 14 2 P62753;A2A3R5 P62753 RPS6 40S ribosomal protein S6 1 14427400.0 5051600.0 6180900.0 3194900.0 True False 4200629.223824634 6147602.264887404 3862938.8184514437 1.0 1.4634955710968627 0.9196095662388106 22.00217401866765 -6.680993365878191 1.8982651359075813 1.2930001965192597 0.9216610920626848 0.3286603072478915 0.19639857515824238 0.43635458702202645 3.0408403328940614 0.08299102987386453 0.21861255954837489 2.084522725251926e-07 6.680993365878191 -0.3713391044565749 NKEPGAEEK(ub)FK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKEPGAEEKFK 11 2 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 11808700.0 2129500.0 4669000.0 5010200.0 True False 2791795.122107337 3972403.3996194536 4491792.565232016 1.0 1.4228849990327925 1.6089262889181732 21.412761641543298 -11.453420631799972 0.14607422168563317 3.6555333489433917e-17 1.8598265854414275 0.9996443345246627 0.004804993622690455 4.158486669864507 0.09240137642392691 1.5173666165418636 0.18504155494643804 3.5202975079959778e-12 11.453420631799972 1.8598265854414275 NKEPGAEEK(ub)FK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKEPGAEEKFK 11 2 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 17512900.0 3535200.0 4564000.0 9413700.0 True False 3422977.011070644 6386429.000945584 6947969.565053473 1.0 1.8657528170041746 2.0298031633231086 21.706820172473634 -10.908885682019134 0.3174989548847451 1.6810023408096696e-10 2.070788552229102 0.9992491579050313 0.012379408676227116 2.698828234426568 0.15970650188029636 2.058372867635667 0.05492751930907109 1.2334294622888225e-11 10.908885682019134 2.0707885520610017 NKEPGAEEK(ub)FK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKEPGAEEKFK 11 2 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 44316700.0 6137700.0 18781000.0 19398000.0 True False 9311339.625974441 15429383.81337724 15563976.797554566 1.0 1.6570530592973125 1.6715077983127244 23.15055731312502 -11.278968303115995 0.6245921575154305 1.1344197743722376e-13 1.6695336640280394 0.9999545353368184 0.0021118237359586995 3.802010222951749 0.31193339533572706 5.271375818245337 0.0024389668859580447 5.260556590423017e-12 11.278968303115995 1.669533664027926 NKEPGAEEK(ub)FK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKEPGAEEKFK 11 2 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 12557000.0 2129500.0 3591900.0 6835600.0 True False 2916833.697573668 3433197.9811750976 5221172.063601063 1.0 1.177029044895827 1.7900136260576769 21.47597170306619 -6.94819021757497 0.5783698928153221 0.9926271273180273 2.0046500267807077 0.9990515101819071 0.010424824792673941 0.08422068124529715 0.03903324803494511 0.010941850895944787 0.05118356872326625 1.1267038606387065e-07 6.94819021757497 1.0120228994626803 NKEPGAEEK(ub)FK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKEPGAEEKFK 11 2 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 12382200.0 3535200.0 4678200.0 4168800.0 True False 2939675.435914329 4652997.608050009 5040476.805646617 1.0 1.582826985320842 1.7146371820734267 21.48722544790791 -11.43734480733689 0.2630137491615532 5.9174088214456274e-09 1.7684424386871644 0.9993044687127874 0.008189147043670287 3.8082002977591274 0.1444916317920562 2.234849436565 0.05650204974639335 3.653046434705526e-12 11.43734480733689 1.7684424327697557 NKEPGAEEK(ub)FK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKEPGAEEKFK 11 2 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 24105000.0 6137700.0 7686300.0 10281000.0 True False 7945373.642154566 7258550.648199282 8409963.49196829 1.0 0.9135568665630385 1.0584730021189717 22.92168363521747 -6.745129386619877 1.6678688328915856 0.9488749040250395 1.0586575325463026 0.6277668008070392 0.036318549101352494 0.3086106062350647 1.6874652872904168 0.017213331368490306 0.04200528281255093 1.7983350686706856e-07 6.745129386619877 0.10978262852126308 NKFDVDAADEK(ub)FR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKFDVDAADEKFR 13 2 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 1 22336400.0 6699700.0 7812700.0 7824000.0 True False 8783371.579987101 6647075.613666072 7014447.533107518 1.0 0.7567795069505454 0.7986053498055264 23.066343407493772 -10.251479523757991 5.478956087504164 1.0000176134096006 0.7776924283780361 0.974137966113233 0.017075328842798065 3.6740635505651237e-06 5.019591335994135e-07 0.016534425101507176 0.0055110386865916084 5.6042884000254253e-11 10.251479523757991 -0.2223251850315645 NKFDVDAADEK(ub)FR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKFDVDAADEKFR 13 2 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 1 22692800.0 8981400.0 6309700.0 7401700.0 True False 8696290.373169808 8829196.114650808 5462972.7237596605 1.0 1.0152830386035692 0.6281957581147789 23.05196868275035 -6.897708691544956 0.9756554598735242 1.0171210223363352 0.589405477970316 0.985390983976637 0.021633060125488147 0.11311103613818542 0.18709140889143847 0.016699055204688496 0.04296880176934075 1.2655849697732632e-07 6.897708691544956 -0.4277155443660192 NKFDVDAADEK(ub)FR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKFDVDAADEKFR 13 2 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 1 51183000.0 17831000.0 18323000.0 15029000.0 True False 27050930.620713044 15053117.491747558 12058511.56255529 1.0 0.5564731839658523 0.44577067353542443 24.689174891490723 -13.99999999999996 0.19491078610105933 3.4193031465143924 0.37015968992292736 0.9994874497153621 0.005421644213726455 12.434832290744014 0.14000303617753868 11.445563751625098 0.07326116420439036 1.000000000000094e-14 13.99999999999996 -3.049143456591465 NKFDVDAADEK(ub)FR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKFDVDAADEKFR 13 2 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 1 20182700.0 6699700.0 7539800.0 5943200.0 True False 9176760.14258479 7206666.705215617 4539538.564046146 1.0 0.7853171046471024 0.4946776959964771 23.129553469016663 -6.966905473300083 0.3236901375743628 1.038118173876451 0.23245107916203558 0.9999472028085741 0.0015046113589316779 0.07732021615486723 0.012611208133187656 0.004341569099007358 0.02548336848933534 1.0791815867684561e-07 6.966905473300083 -0.8056670947144153 down NKFDVDAADEK(ub)FR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKFDVDAADEKFR 13 2 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 1 26550700.0 8981400.0 10737000.0 6832300.0 True False 7468432.043482964 10679157.64987236 8260902.341014057 1.0 1.4299062490889385 1.106109326953388 22.832373958184625 -10.130318814889312 6.528684795500635 0.9999994373049932 1.2680077880211635 0.4773857087673232 0.13218953991930044 1.0827418500294272e-06 1.4431315268042368e-07 0.1279922405731308 0.04266399055418905 7.407662463276616e-11 10.130318814889312 0.26800835071617035 NKFDVDAADEK(ub)FR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKFDVDAADEKFR 13 2 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 1 64229000.0 17831000.0 15607000.0 30791000.0 True False 23082581.001557298 14738456.730344385 25187353.942339826 1.0 0.6385099105403349 1.0911844711230745 24.460301213583172 -6.694017972084695 1.8517804068547938 0.7742202902024913 1.0897113296637753 0.38927111601160946 0.15276418853174883 0.40819215312228857 2.716749276641265 0.06591417665153927 0.17080349866182304 2.022935463316325e-07 6.694017972084695 0.315491039461284 NKFDVQK(ub)ALSGVLEQDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKFDVQKALSGVLEQDR 17 2 Q9Y450;Q9Y450-4;E9PN23;G5E991;E9PMN1;E9PLR4;Q9Y450-2;E9PJ90 Q9Y450 HBS1L HBS1-like protein 1 73906000.0 23957000.0 29252000.0 20697000.0 True False 36344520.49130293 24031752.05308082 16606228.87818265 1.0 0.6612207762881753 0.45691148634514084 25.11523453575902 -9.302424910249965 0.12189410593662324 1.6206248213460066 1.1349805657030209e-11 0.9999085531198357 0.002141759327898085 0.7479739955600664 0.04454105909897736 0.3649311134612083 0.20720256518285202 4.983966215658144e-10 9.302424910249965 -1.6206248213346568 NKFDVQK(ub)ALSGVLEQDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKFDVQKALSGVLEQDR 17 2 Q9Y450;Q9Y450-4;E9PN23;G5E991;E9PMN1;E9PLR4;Q9Y450-2;E9PJ90 Q9Y450 HBS1L HBS1-like protein 1 62417000.0 23957000.0 25656000.0 12804000.0 True False 31012808.763070397 24228221.04656344 10473803.380134413 1.0 0.7812327232809062 0.3377250819218434 24.886360857851468 -6.959778862864147 0.43854093855675863 1.016101357696601 0.08560660301892888 0.9997619047889205 0.004251252162898186 0.07978023071472833 0.0214240679645783 0.005836962178642567 0.0367576911449796 1.0970366508328517e-07 6.959778862864147 -0.9304947546776721 down NKGDSHLNVQVSNFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKGDSHLNVQVSNFK 15 1 E5RJU9;Q86UE4 E5RJU9 MTDH Protein LYRIC 0 12857900.0 5005500.0 4139500.0 3712900.0 False True 6562258.973330958 3521902.7356446227 3328724.724651697 1.0 0.5366906045551764 0.5072528740757787 22.645761098896436 -13.999999999999998 0.3918741619311876 8.413602100147685 0.5051871455212322 0.9998259558133157 0.0029770970838464144 25.607448584720714 0.20539597353757527 160.92173338631466 0.007706252440622941 1.0000000000000041e-14 13.999999999999998 -7.908414954626453 NKLDHYAIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKLDHYAIIK 10 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9 P62750 RPL23A 60S ribosomal protein L23a 0 10443300.0 1876000.0 4282100.0 4285200.0 False True 2459454.1672098446 3643227.37149507 3841808.610540943 1.0 1.481315415455849 1.562057411665177 21.229906739508337 -11.786756247497767 0.2965106356698304 7.176206568562488e-20 1.5849124300430153 0.9994264144761779 0.005942493316106266 4.620420502764673 0.1616030832920984 2.9128241398019017 0.02958389958982071 1.6339687733295221e-12 11.786756247497767 1.5849124300430153 NKLDHYAIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKLDHYAIIK 10 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9 P62750 RPL23A 60S ribosomal protein L23a 0 10662300.0 1876000.0 3472000.0 5314300.0 False True 2569607.8969937544 3318595.5596313784 4059171.79144407 1.0 1.2914793589768627 1.5796852882468926 21.29311680103123 -6.971264434984217 0.22595406100245452 0.8766915968180531 2.0026682973266645 0.9999906352225605 0.000724192280013012 0.0758944967454109 0.0075453309545966026 0.007631248164067691 0.028854324816721278 1.0684041468855874e-07 6.971264434984217 1.1259767005086114 NKLEELQTLCK(ub)TPPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKLEELQTLCKTPPR 15 2 O94986;O94986-3;O94986-1;O94986-2 O94986 CEP152 Centrosomal protein of 152 kDa 1 25681600.0 7932000.0 8979900.0 8769700.0 True False 12033423.906875439 7377366.684721071 7036364.951103952 1.0 0.6130729492963284 0.5847350683859514 23.520543859564732 -13.999999999999998 0.37096015205819377 6.422227618160951 0.581841403628406 0.999792539499714 0.0027284764892642885 22.932565081614634 0.19778128284847793 98.9229326566965 0.007896121391359794 1.0000000000000041e-14 13.999999999999998 -5.840386214532545 NKLEELQTLCK(ub)TPPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKLEELQTLCKTPPR 15 2 O94986;O94986-3;O94986-1;O94986-2 O94986 CEP152 Centrosomal protein of 152 kDa 1 25861800.0 7932000.0 10133000.0 7796800.0 True False 10268130.363095315 9569089.64237713 6377862.401923785 1.0 0.9319213239412497 0.6211318104069323 23.29167018165718 -6.9418539843599785 0.6420889762816858 1.0034076502579252 0.5325452523153564 0.9983967290667122 0.006603246728579911 0.08693106927127844 0.05083475568708018 0.006521905668343762 0.026538227534485443 1.1432626504441302e-07 6.9418539843599785 -0.4708623979425688 NKPQENGQDDTSK(ub)ADKPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKPQENGQDDTSKADKPK 18 3 Q86SE9 Q86SE9 PCGF5 Polycomb group RING finger protein 5 1 2302310.0 260370.0 788240.0 1253700.0 True False 395000.3255967171 647572.4134527695 1005905.6454837702 1.0 1.6394224801574482 2.546594471698659 18.591494316933073 -6.9661663033902625 0.33743655997809885 0.898635993747677 3.3174121143003283 0.9999352077576761 0.005107644716861303 0.0775673831440013 0.013476551263230864 0.012908898647616985 0.07866901400341943 1.0810199195515084e-07 6.9661663033902625 2.4187761205526512 NKPQENGQDDTSK(ub)ADKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKPQENGQDDTSKADKPK 18 3 Q86SE9 Q86SE9 PCGF5 Polycomb group RING finger protein 5 1 1797420.0 260370.0 611350.0 925700.0 True False 337054.09766000113 577327.8350801597 757232.0984841014 1.0 1.7128640152671621 2.2466188773291496 18.362620639025522 -7.028670929008666 0.11808531362960946 1.6026291888724873e-12 3.9442213869113756 0.9999995487726653 0.0003429914647329948 0.07201518390582894 0.003521568043240131 0.03913580239545926 0.07688868626620621 9.361147126746225e-08 7.028670929008666 3.944221386909773 NKPSDLGTK(ub)LQDPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKPSDLGTKLQDPR 14 2 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 31148800.0 10182000.0 15645000.0 5321800.0 True False 13348700.602628255 13310826.983732367 4771151.1863102745 1.0 0.9971627486432326 0.35742439120785074 23.67019597725678 -6.907871875604269 0.9100906758896593 1.0211656255873396 0.27840084527475895 0.9900936303945277 0.030082821363452444 0.10584286635279129 0.14652017720653682 0.024372875032659686 0.06632947109161712 1.2363121131392767e-07 6.907871875604269 -0.7427647803125806 down NKPSDLGTK(ub)LQDPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKPSDLGTKLQDPR 14 2 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 44953000.0 18419000.0 14117000.0 12417000.0 True False 17834298.92705086 19753991.71918247 9164615.19798474 1.0 1.1076404965501527 0.5138758319276547 24.088151168250256 -6.859975726543259 1.1858952919515753 1.058395104971991 0.48514131775651875 0.9536079521761627 0.05563427499489138 0.1468258249307011 0.3923860558297655 0.03659113435631754 0.08541016999751198 1.3804614187817194e-07 6.859975726543259 -0.5732537872154724 NKPSDLGTK(ub)LQDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKPSDLGTKLQDPR 14 2 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 68945000.0 28563000.0 23286000.0 17096000.0 True False 43332159.23500799 19130431.365651596 13716968.106557012 1.0 0.441483454860845 0.3165539947401258 25.368934791890414 -13.999999999999945 0.210428004222298 4.235795459194949 0.24327519364972508 0.9994902561197522 0.006708749780557901 12.756748848237573 0.1453934266119572 17.069751131961585 0.07378078926273532 1.0000000000001268e-14 13.999999999999945 -3.992520265545224 NKPSDLGTK(ub)LQDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKPSDLGTKLQDPR 14 2 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 30716200.0 10182000.0 12550000.0 7984200.0 True False 13946560.558203824 11995499.502699807 6098496.399760604 1.0 0.8601045005066615 0.4372760132729118 23.73340603877967 -6.951282688872562 0.5445780251131276 1.0060444766675227 0.2716559361176654 0.9992981479795442 0.006337389847396395 0.0829746922188697 0.03386186509579222 0.006927396900506258 0.035042837493182113 1.1187094614475475e-07 6.951282688872562 -0.7343885405498574 down NKPSDLGTK(ub)LQDPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKPSDLGTKLQDPR 14 2 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 46524500.0 18419000.0 21673000.0 6432500.0 True False 15316214.600052621 21556243.2472463 7777506.009480404 1.0 1.4074132421187309 0.5077955756413652 23.868556443684533 -6.783583971154718 1.5219213408960035 1.229613471128591 0.49985352863673005 0.7798644283711311 0.17257167874838958 0.24504418213223406 1.1212678874771138 0.08928943991220085 0.21006210158659142 1.64594769037386e-07 6.783583971154718 -0.729759942491861 NKPSDLGTK(ub)LQDPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NKPSDLGTKLQDPR 14 2 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 1 69014000.0 28563000.0 28705000.0 11746000.0 True False 36975366.56090414 27107541.51627704 9608348.524137689 1.0 0.733124348385478 0.2598581006171029 25.140061113982863 -7.060861292025969 0.4254957395321846 1.0208801459957002 1.4527562301629474e-16 0.9997971062665144 0.004359432606913225 0.07379741490335961 0.02054999151638338 0.006460174209830111 0.036867292331546044 8.692380082007539e-08 7.060861292025969 -1.0208801459957 down NKQDLPNAMNAAEITDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKQDLPNAMNAAEITDK 17 1 H0YGG7 H0YGG7 0 9342000.0 2487100.0 2322300.0 4532600.0 False True 3260612.185110658 1975821.8922544983 4063610.0317693125 1.0 0.6059665425029512 1.246272111208283 21.636711427494422 -6.740206841628154 1.6859479321721067 0.7656100709644836 1.246664776243709 0.6058881724307024 0.16555495486794145 0.317431455530283 1.7717026265291933 0.07768134759403977 0.19057912277466363 1.8188343952157514e-07 6.740206841628154 0.48105470527922545 NKQDLPNAMNAAEITDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKQDLPNAMNAAEITDK 17 1 H0YGG7 H0YGG7 0 11149900.0 2487100.0 2380300.0 6282500.0 False True 3406648.0813502967 2275130.4754005093 4798702.892148989 1.0 0.6678501627026627 1.408628886094663 21.699921489017314 -6.784798861093139 1.516913175168118 0.8130969810473686 1.4154313316049647 0.7840663947375751 0.14078070451775002 0.243199129407452 1.1055120725007328 0.07307173946946174 0.17175918500743315 1.6413497710213108e-07 6.784798861093139 0.6023343505575961 NKTEDLEATSEHFK(ub)TTSQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKTEDLEATSEHFKTTSQK 19 2 Q9BV40;C9JXZ5 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 42220700.0 17425000.0 14978000.0 9817700.0 True False 22844343.743940014 12743340.783786722 8801858.582028316 1.0 0.5578335244218685 0.3852970643712718 24.445333662636106 -13.999999999999998 0.13013838471234362 3.1013164438875056 0.1440957429235686 0.99964499027747 0.004877615141207957 11.936490689025213 0.11219722858656735 6.415021647323866 0.21451831596995932 1.0000000000000041e-14 13.999999999999998 -2.957220700963937 NKTEDLEATSEHFK(ub)TTSQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKTEDLEATSEHFKTTSQK 19 2 Q9BV40;C9JXZ5 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 36457000.0 11240000.0 11942000.0 13275000.0 True False 10883192.352464937 16710502.8767073 9797879.258536497 1.0 1.5354412874015348 0.9002762187068551 23.37559846671228 -6.683151968903111 1.8902432515416017 1.3377995648123813 0.9026018959173757 0.3388694943897199 0.2267750168643415 0.43152219669180447 2.98351723011682 0.0961617133263758 0.25264184395660244 2.0741875879718875e-07 6.683151968903111 -0.43519766889500555 NKTEDLEATSEHFK(ub)TTSQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NKTEDLEATSEHFKTTSQK 19 2 Q9BV40;C9JXZ5 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 115201000.0 38572000.0 35425000.0 41204000.0 True False 58516543.99092273 29103131.97321172 33060011.339645218 1.0 0.4973487835803545 0.5649686239975756 25.802341230092743 -10.48958578065728 6.161704920967449 1.0003357407458764 0.5311587037891397 0.9846384638764937 0.02760568425176985 0.00012741081933119903 1.0554266524784257e-05 0.02674761946694889 0.00890969628064707 3.2390243979291885e-11 10.48958578065728 -0.46917703695673674 NKTEDLEATSEHFK(ub)TTSQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKTEDLEATSEHFKTTSQK 19 2 Q9BV40;C9JXZ5 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 37106600.0 17425000.0 10390000.0 9291600.0 True False 23867493.392919026 9930935.444864638 7097115.446508816 1.0 0.4160862341669668 0.2973548721548773 24.508543724158997 -13.999999999999998 0.22391690421849875 4.585314641631527 0.23618071841658703 0.9995021174814295 0.0068522807239609984 13.109149311134413 0.14987506714938376 20.826101303354054 0.0640521420679502 1.0000000000000041e-14 13.999999999999998 -4.34913392321494 NKTEDLEATSEHFK(ub)TTSQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NKTEDLEATSEHFKTTSQK 19 2 Q9BV40;C9JXZ5 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 34130200.0 11240000.0 14772000.0 8118200.0 True False 9346558.016428225 14692420.303987557 9815678.085684225 1.0 1.5719605311562863 1.0501917463553363 23.156003742146556 -10.381570513184101 3.896863796705154 0.9987912454725492 1.3110761387631682 0.3215426060810326 0.2130112144813203 16943879.408262193 51221323.1307113 95738.81372980775 0.07291940894783074 4.15364606086602e-11 10.381570513184101 0.31228489329061904 NKYETEINITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NKYETEINITK 11 1 P15924;P15924-3 P15924 DSP Desmoplakin 0 9210800.0 2530300.0 3137100.0 3543400.0 False True 3317247.8034600574 2669056.9083200255 3176762.958692886 1.0 0.804599796715839 0.9576501807852164 21.66155535699112 -9.907207206942866 5.100964307246146 1.0000003168060732 0.8811249887836808 0.4457871913560917 0.06248255766022706 85326086.90363495 11.802357410669329 317.50571172024775 0.02138944142432138 1.2382056832614507e-10 9.907207206942866 -0.11887532802239231 NKYETEINITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NKYETEINITK 11 1 P15924;P15924-3 P15924 DSP Desmoplakin 0 4564730.0 1070500.0 773330.0 2720900.0 False True 1036517.5634620745 1082124.7018626754 2008214.664749675 1.0 1.04400035272752 1.9374632283528634 19.9833131319895 -6.917143986524043 0.8456404019716541 0.9781851719793666 2.0724837924703556 0.9933500838481872 0.03522236726301402 0.0998813934756539 0.11453781807110731 0.029897386945887578 0.08725103633748063 1.2101968368905587e-07 6.917143986524043 1.094298620490989 NKYETEINITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NKYETEINITK 11 1 P15924;P15924-3 P15924 DSP Desmoplakin 0 6719700.0 2530300.0 1846400.0 2343000.0 False True 3465820.2887864043 1764819.9427717088 1789631.655599694 1.0 0.5092069973973407 0.5163659700966069 21.72476541851401 -10.273981563588213 8.505956991723336 1.0000003252653 0.5127864837472925 0.9998380968138928 0.00292263836595291 1.802828446840798e-08 1.536809105497555e-09 0.002829834327016168 0.0009432774765268752 5.321308484905175e-11 10.273981563588213 -0.4872138415180075 NLAFYWILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLAFYWILK 9 0 Q9HB40;I3L4Z9 Q9HB40 SCPEP1 Retinoid-inducible serine carboxypeptidase 0 37201100.0 7781100.0 10707000.0 18713000.0 False True 11804497.574607708 8796252.195827175 15014367.347800724 1.0 0.7451610829035641 1.2719192200181115 23.49283330280925 -6.77515363105965 1.5547195642556442 0.8547954287625009 1.275477428251248 0.7498796133149677 0.1075687848914586 0.2581780074467922 1.2322255986796058 0.05451413113353175 0.12916305921680438 1.678210248600761e-07 6.77515363105965 0.42068199948874707 NLAFYWILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLAFYWILK 9 0 Q9HB40;I3L4Z9 Q9HB40 SCPEP1 Retinoid-inducible serine carboxypeptidase 0 26323200.0 7781100.0 9513100.0 9029000.0 False True 10072787.338411601 8983687.622313008 7385814.645363455 1.0 0.891877026734654 0.7332443738982123 23.263959624901698 -6.965623301922756 0.3472010431176197 1.015832151733473 0.6039594358238657 0.9999254076400867 0.0009461429832327748 0.07775020244464238 0.014118521593738604 0.00219347308220391 0.013660587879965073 1.0823723717295509e-07 6.965623301922756 -0.4118727159096073 NLAMEATYINHNFSQQCLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLAMEATYINHNFSQQCLR 19 0 O15371-2;O15371-3;O15371 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 0 18012900.0 3987900.0 7965800.0 6059200.0 False True 5228175.51887853 6777333.6904452 5432252.107950537 1.0 1.296309518678702 1.0390339972969735 22.317876145033853 -9.752739995932128 6.828948458473274 1.000000008054825 1.167671757987858 0.3615607165490461 0.10503229178236319 7.769122146500539e-10 1.979424870867467e-18 0.10169707922174005 0.03389902640724669 1.7670954313958513e-10 9.752739995932128 0.1676717499330329 NLAMEATYINHNFSQQCLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLAMEATYINHNFSQQCLR 19 0 O15371-2;O15371-3;O15371 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 0 16227700.0 3987900.0 5578900.0 6660900.0 False True 5462334.398945296 5332405.751044782 5087732.6055416195 1.0 0.9762137140623244 0.9314209336074322 22.381086206556745 -6.96120770512327 0.41810380991920065 1.0020208098767527 0.9039294980861386 0.9998122741331785 0.00038950912440784347 0.07927303283255577 0.0195612311811074 0.000578769820203101 0.0037306269816615683 1.0934332971911353e-07 6.96120770512327 -0.09809131179061403 NLAMGVNLTSMSK ddPTM_RPMI8226_Bortezomib_1h_R1 4 NLAMGVNLTSMSK 13 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 253209000.0 66748400.0 81800400.0 104660200.0 False True 87507798.79242516 69596099.17546177 93830966.475529 1.0 0.7953131050701979 1.0722583332041393 26.382908261473972 -6.708687174361014 1.7998243431703838 0.874000163509788 1.0715863877806728 0.4590060237230177 0.08627093127553555 0.3776608980693422 2.383940038828512 0.03815625276135282 0.09709163157101376 1.9557476885615582e-07 6.708687174361014 0.1975862242708848 NLAMGVNLTSMSK ddPTM_RPMI8226_Bortezomib_2h_R1 3 NLAMGVNLTSMSK 13 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 203166800.0 66448900.0 35762500.0 100955400.0 False True 64339516.04178899 50042652.748973764 74512152.14291938 1.0 0.7777903196609482 1.1581086822991207 25.93920174837227 -6.748361384397891 1.6561352005948913 0.8690785806121825 1.1587601960580967 0.6417785341297055 0.09336713031014582 0.3029213663827083 1.6342186852963791 0.04454683313945516 0.10832479876009732 1.7850016241284563e-07 6.748361384397891 0.2896816154459142 NLAMGVNLTSMSK ddPTM_RPMI8226_Bortezomib_8h_R1 4 NLAMGVNLTSMSK 13 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 609272100.0 137690200.0 274720700.0 196861200.0 False True 208886099.90197402 225694644.68237394 157951497.53267094 1.0 1.0804675121431624 0.7561608819677056 27.638141252127674 -6.841030180664711 1.2775715540905193 1.0428024682833639 0.7452724807413904 0.9262200146298302 0.03745263046446578 0.16759486139419533 0.5309161637369555 0.0229830651186028 0.052964941875970784 1.4420151372936765e-07 6.841030180664711 -0.29752998754197346 NLAMGVNLTSMSK ddPTM_RPMI8226_Carfilzomib_1h_R1 4 NLAMGVNLTSMSK 13 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 247376600.0 66748400.0 66306600.0 114321600.0 False True 91427087.28768545 63376955.16539572 87321192.60725838 1.0 0.6931966996386215 0.9550910479351986 26.446118322996863 -10.111618737840992 6.886239188988899 1.0000001341378773 0.8241438744272905 0.3754589579624935 0.10691791997422534 2.2014182195043333e-07 2.844975500706926e-08 0.10352290954053443 0.03450761028927597 7.733592103799746e-11 10.111618737840992 -0.17585625971058672 NLAMGVNLTSMSK ddPTM_RPMI8226_Carfilzomib_2h_R1 3 NLAMGVNLTSMSK 13 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 144381400.0 66448900.0 31327700.0 46604800.0 False True 55255204.53539487 31158931.462038442 56349648.203751616 1.0 0.563909440278679 1.0198070693531807 25.719607023806546 -10.994120032013482 11.91587003654184 1.177130870637232 0.7918582548158928 0.2174794412486979 0.18611942769619363 0.06661666397536481 3.2872441030698635e-05 0.013707147704152519 0.06006978698941781 1.0136311956501637e-11 10.994120032013482 -0.3852726158213393 NLAMGVNLTSMSK ddPTM_RPMI8226_Carfilzomib_8h_R1 4 NLAMGVNLTSMSK 13 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 567346200.0 137690200.0 269749500.0 159906500.0 False True 178242678.17960972 254737703.19613206 130805157.77924606 1.0 1.4291622286972183 0.733859921289096 27.409267574220124 -6.739740375169194 1.6877933640919005 1.2554264755067248 0.7334863537531557 0.6037337385201241 0.18031614874266183 0.31827623502421254 1.7801544785661743 0.08452367445062484 0.2074608825730635 1.8207890160457735e-07 6.739740375169194 -0.5219401217535691 NLAVAMCSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLAVAMCSR 9 0 D6REN3;E2QRC7;D6RB92;H7C465;Q5JS54-3;Q5JS54;Q5JS54-2 D6REN3 PSMG4 Proteasome assembly chaperone 4 0 4717900.0 1860500.0 1420100.0 1437300.0 False True 2548377.1281220005 1357355.2863572934 1097839.3421226821 1.0 0.5326351705870088 0.4307994017085388 21.281147363641622 -13.999999999999998 0.21413580721966574 3.749947521272049 0.37316907245919506 0.9994927333267489 0.00558183071155833 12.846670448202307 0.14664091134884885 14.893638036607413 0.05862086044019672 1.0000000000000041e-14 13.999999999999998 -3.376778448812854 NLAVK(ub)VYTPVASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLAVKVYTPVASR 13 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 18669200.0 4191300.0 7878000.0 6599900.0 True False 5494834.888606935 6702633.108203481 5917005.658711176 1.0 1.2198060986510826 1.07683047419306 22.389644700368237 -10.186674433048054 3.7898489328220535 0.9998786810408049 1.1483182864153756 0.5892957537764867 0.05836955458118945 41302877.12633822 76215875.40748648 61479.19685551548 0.02136107370153575 6.50617239933469e-11 10.186674433048054 0.14843960537457068 NLAVK(ub)VYTPVASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLAVKVYTPVASR 13 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 39336900.0 8986900.0 9802100.0 20547900.0 True False 8701615.778680356 13716129.647276225 15165788.566213313 1.0 1.576273877879304 1.7428703992390344 23.052851885164902 -11.335873352277677 0.22607165043389954 7.580129374777239e-18 1.8411453861783238 0.9993115124968313 0.0083512834568284 3.6671841767238202 0.12776683652930956 1.915198592320854 0.0878643703596158 4.6145212229743065e-12 11.335873352277677 1.8411453861783238 NLDDLTLLK(ub)QLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLDDLTLLKQLR 12 1 C9JQ41;H7C525;Q4VC31 C9JQ41 CCDC58 Coiled-coil domain-containing protein 58 1 12916770.0 2854210.0 7926100.0 2136460.0 True False 3741896.9502089587 6743556.775695811 1915399.6135714313 1.0 1.8021759726224504 0.5118793058864086 21.835338397419275 -6.738568990168311 1.691874601049203 1.4780854506185033 0.5113491361025226 0.5985058155862135 0.33705432247016415 0.32042126459981285 1.8003328831522125 0.15763581811836183 0.38744255947656453 1.825706702061152e-07 6.738568990168311 -0.9667363145159806 NLDDLTLLK(ub)QLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLDDLTLLKQLR 12 1 C9JQ41;H7C525;Q4VC31 C9JQ41 CCDC58 Coiled-coil domain-containing protein 58 1 21133000.0 10713200.0 6225100.0 4194700.0 True False 10373115.330109201 8710814.893467646 3095982.2316973982 1.0 0.8397491608122267 0.29846214306621477 23.30634590419926 -6.948758536620283 0.5723099243221542 1.0066743165750267 0.10511535642002452 0.9991002297606636 0.009003443801746669 0.08398810112885022 0.038055129690651786 0.009513658493529052 0.04512574230370813 1.1252304169162753e-07 6.948758536620283 -0.9015589601550021 down NLDDLTLLK(ub)QLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLDDLTLLKQLR 12 1 C9JQ41;H7C525;Q4VC31 C9JQ41 CCDC58 Coiled-coil domain-containing protein 58 1 25075300.0 8951100.0 3646600.0 12477600.0 True False 13579473.113065146 2995835.738984157 10011396.890873633 1.0 0.22061502048277482 0.7372448700709471 23.694924167953637 -9.936495077112282 6.322335279634959 1.0000000984150228 0.47892994528646576 0.575614943615613 0.2109132528970955 2.924690580911374e-07 4.957577084017912e-08 0.20421591550738452 0.06807195966372247 1.1574571522204954e-10 9.936495077112282 -0.5210701531285571 NLDDLTLLK(ub)QLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLDDLTLLKQLR 12 1 C9JQ41;H7C525;Q4VC31 C9JQ41 CCDC58 Coiled-coil domain-containing protein 58 1 20655450.0 10713200.0 9165900.0 776350.0 True False 8908500.47523122 9116521.477411307 938681.1955631721 1.0 1.0233508436979333 0.10536915816225612 23.086751179633538 -6.901066521856133 0.9545261629252979 1.0370588635657356 0.0069060674923922104 0.9870884028904984 0.048558670647456635 0.11062456789269487 0.17303759555046822 0.03807714840101234 0.09960818192910459 1.255837589512569e-07 6.901066521856133 -1.0301527960733434 down NLDDLTLLK(ub)QLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLDDLTLLKQLR 12 1 C9JQ41;H7C525;Q4VC31 C9JQ41 CCDC58 Coiled-coil domain-containing protein 58 1 18899400.0 8951100.0 3991500.0 5956800.0 True False 11587375.402559564 3769369.516189512 4872723.52192945 1.0 0.32529968049165703 0.4205200360431149 23.466050490046086 -10.772559440031038 7.126002305907688 1.0150171672845336 0.372909858267386 0.9830013266825504 0.03887354737124388 0.008952752475435075 0.00028574451684097794 0.036333427058883656 0.012546383464736062 1.688264778083285e-11 10.772559440031038 -0.6421073090171476 NLDDTIDDEK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLDDTIDDEKLR 12 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6;P0CB38 B1ANR0;P0CB38 PABPC4;PABPC4L Polyadenylate-binding protein;Polyadenylate-binding protein 4;Polyadenylate-binding protein 4-like 1 22247250.0 7904950.0 7166100.0 7176200.0 True False 10363466.001644699 6096945.813239023 6433675.662971139 1.0 0.5883114599180842 0.6208034707645207 23.30500324900401 -9.848958614276214 5.396231820939786 1.0000002431067894 0.6045574659644075 0.9949620450745944 0.013264807898796862 18007899.548064098 2.4728907929417674 54.395436692283546 0.004540896564355443 1.4159287032514414e-10 9.848958614276214 -0.39544277714238185 NLDDTIDDEK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLDDTIDDEKLR 12 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6;P0CB38 B1ANR0;P0CB38 PABPC4;PABPC4L Polyadenylate-binding protein;Polyadenylate-binding protein 4;Polyadenylate-binding protein 4-like 1 22455700.0 1051100.0 10995500.0 10409100.0 True False 1017733.4058430502 15386060.490775011 7682644.443693569 1.0 15.117967438663179 7.548778884121986 19.95692826783171 -9.688683468453668 12.392937716418258 0.9999310447899374 11.333373161392583 0.7130549748520846 3.0901082878465345 0.0 0.0 2.9919844840859073 0.9973281613619689 2.0479367127888048e-10 9.688683468453668 10.333442116602646 NLDDTIDDEK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLDDTIDDEKLR 12 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6;P0CB38 B1ANR0;P0CB38 PABPC4;PABPC4L Polyadenylate-binding protein;Polyadenylate-binding protein 4;Polyadenylate-binding protein 4-like 1 25682600.0 2416000.0 15199000.0 8067600.0 True False 3665248.633259082 12486619.699670997 6473035.323845301 1.0 3.4067592540285836 1.7660562683545913 21.805479636660962 -9.533415378557311 8.470801152291433 0.9999376260442141 2.5864077612058813 0.5548723145163382 0.6698141900284867 0.0 0.0 0.6485448003209904 0.21618160010699675 2.928091348744783e-10 9.533415378557311 1.5864701351616672 NLDDTIDDEK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLDDTIDDEKLR 12 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6;P0CB38 B1ANR0;P0CB38 PABPC4;PABPC4L Polyadenylate-binding protein;Polyadenylate-binding protein 4;Polyadenylate-binding protein 4-like 1 25427450.0 7904950.0 7916400.0 9606100.0 True False 10827623.63824135 7566627.27196596 7337337.023839621 1.0 0.6988262175314167 0.6776498028547443 23.3682133105269 -13.999999999999998 0.3769505834006419 5.383009574137375 0.675689177928005 0.9998025565634915 0.0020686483699542545 23.65487607241172 0.1999345644530485 84.02845139218873 0.005792940309822246 1.0000000000000041e-14 13.999999999999998 -4.70732039620937 NLDDTIDDEK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLDDTIDDEKLR 12 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6;P0CB38 B1ANR0;P0CB38 PABPC4;PABPC4L Polyadenylate-binding protein;Polyadenylate-binding protein 4;Polyadenylate-binding protein 4-like 1 19089700.0 1051100.0 11471900.0 6566700.0 True False 874036.2216252402 11410098.597706141 7939766.609009707 1.0 13.054491696567743 9.08402468063164 19.737333543265986 -9.81609689262886 7.664886308924498 1.000000007815719 11.069258188599704 0.8955648845606954 1.620936371599119 2.2871999206493092e-07 2.4409337925666303e-08 1.5694649165031103 0.523154964372098 1.5272252908837313e-10 9.81609689262886 10.069258180783985 NLDDTIDDEK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLDDTIDDEKLR 12 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6;P0CB38 B1ANR0;P0CB38 PABPC4;PABPC4L Polyadenylate-binding protein;Polyadenylate-binding protein 4;Polyadenylate-binding protein 4-like 1 33842900.0 2416000.0 3284700.0 28142200.0 True False 3127559.626479862 3101903.5575166442 23020608.36335667 1.0 0.9917967770315241 7.3605657805689475 21.57660595875341 -6.9066063083662526 0.9185425919666199 0.7810278871613758 8.126545947143285 0.9895764519242496 0.30632152361440945 0.10670498613381772 0.15125982707300872 0.24665517400067943 0.6658805425211044 1.2399200752989692e-07 6.9066063083662526 7.345518059981909 up NLDDTIDDEKLRK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLDDTIDDEKLRK 13 2 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 30383900.0 4803400.0 6586500.0 18994000.0 True False 6218095.989169445 6219955.48500117 15537286.894897956 1.0 1.0002990458550276 2.498720978569725 22.56804145715623 -6.906937309155725 0.9163439343095447 0.9489935208341044 2.680194941766382 0.9897134377223834 0.0716483732106459 0.1064781477500786 0.15001297802985644 0.05778530010831346 0.1563224606587931 1.238975420967915e-07 6.906937309155725 1.7312014209322775 up NLDIERPTYTNLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLDIERPTYTNLNR 14 1 F8VVB9;P68363;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 236775400.0 22565400.0 110780000.0 103430000.0 False True 29583457.92364448 94252055.81705782 92728055.77061738 1.0 3.185971567635005 3.1344562900642114 24.818287358897447 -10.080668448456219 4.569126283362228 0.9998641770352051 3.160213928931567 0.9995736613792968 0.021031024276340175 1580454.687410941 1162299.167162446 1928.6074151102885 0.00719947907806208 8.304845387574278e-11 10.080668448456219 2.1603497518963617 NLDIERPTYTNLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLDIERPTYTNLNR 14 1 F8VVB9;P68363;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 167626500.0 53560500.0 21878000.0 92188000.0 False True 51860251.2450354 30613999.492262818 68041197.21928151 1.0 0.5903172228690948 1.3120105588727766 25.628125859779693 -6.752748466664449 1.6400644656754886 0.7598964665164413 1.3137165897584615 0.6605629920012965 0.17217829746773416 0.29527171167303984 1.56350917978387 0.0829100865964753 0.20067495453950146 1.7670609652742875e-07 6.752748466664449 0.5538201232420202 NLDIERPTYTNLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLDIERPTYTNLNR 14 1 F8VVB9;P68363;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 251025400.0 22565400.0 122900000.0 105560000.0 False True 30908438.187005803 117469871.62404847 80628902.07644203 1.0 3.8005761052473335 2.6086372138447027 24.881497420420338 -9.776080657964703 6.887744481208839 0.9999999919685045 3.204606659546164 0.8201874044469373 0.48660701475304224 6.176149408744196e-08 1.0193118896621184e-08 0.4711552160713179 0.15705173869044198 1.674631831459894e-10 9.776080657964703 2.2046066675776594 NLDISRPDKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLDISRPDKK 10 2 P46977;P46977-2;H0YET6 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 9850500.0 1775300.0 1089500.0 6985700.0 True False 2431676.3856785735 1041362.287505294 5335821.5350075895 1.0 0.428248715017519 2.1942975498027044 21.213519812973296 -6.819544077203016 1.3737659233161 0.6916771810332045 2.2324986146833945 0.8833367769102133 0.25130848652215254 0.19408347668138196 0.7198327266694718 0.14375514382544582 0.33138634466063144 1.5151510209291016e-07 6.819544077203016 1.54082143365019 up NLDK(ub)SIDNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLDKSIDNK 9 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;E5RH24;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEQ8;B1ANR1;P0CB38 P11940;B1ANR0;P0CB38 PABPC1;PABPC4;PABPC4L Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4;Polyadenylate-binding protein 4-like 1 74811000.0 23915000.0 30406000.0 20490000.0 True False 31352796.59318944 25869543.321659673 18369891.35395869 1.0 0.8251111904728505 0.5859091803615712 24.902090797866627 -6.966745820135453 0.32670616338233605 1.0302846587445238 0.37294346768480385 0.9999447395206419 0.0012617164459945867 0.07737342245170546 0.012797332239970384 0.0035324832205314064 0.020920057251170212 1.0795783830338191e-07 6.966745820135453 -0.65734119105972 NLDK(ub)SIDNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLDKSIDNK 9 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;E5RH24;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEQ8;B1ANR1;P0CB38 P11940;B1ANR0;P0CB38 PABPC1;PABPC4;PABPC4L Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4;Polyadenylate-binding protein 4-like 1 79960000.0 30298000.0 34247000.0 15415000.0 True False 29336206.57428669 47922005.69574573 11377349.059912603 1.0 1.6335447316405785 0.3878261843808019 24.80617899431327 -6.768435914573577 1.58037853016804 1.364101583583784 0.38121698458828407 0.7245951585209154 0.266901732323936 0.2689500350165276 1.325431375445189 0.13313701630341096 0.3173862978653486 1.7043708013761536e-07 6.768435914573577 -0.9828845989955 NLDK(ub)SIDNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLDKSIDNK 9 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;E5RH24;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEQ8;B1ANR1;P0CB38 P11940;B1ANR0;P0CB38 PABPC1;PABPC4;PABPC4L Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4;Polyadenylate-binding protein 4-like 1 115680000.0 35992000.0 48145000.0 31543000.0 True False 54602495.36765771 39553148.59139805 25308512.224211987 1.0 0.7243835345815766 0.46350468149488255 25.70246354891493 -6.971791139462675 0.21107421803680176 1.1347272624769937 0.045869468503767566 0.9999931852387776 0.0005718052126921 0.07572574588422112 0.0069109615179862435 0.007745901531666126 0.02696659436873316 1.0671091911033603e-07 6.971791139462675 -1.0888577939732262 down NLDK(ub)SIDNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLDKSIDNK 9 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;E5RH24;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEQ8;B1ANR1;P0CB38 P11940;B1ANR0;P0CB38 PABPC1;PABPC4;PABPC4L Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4;Polyadenylate-binding protein 4-like 1 66018000.0 23915000.0 28056000.0 14047000.0 True False 32757021.778574407 26816393.151214812 10729387.907046068 1.0 0.8186456428329751 0.3275446705617147 24.96530085938952 -6.95372766197695 0.5163020402779789 1.008590024914925 0.11582211765576968 0.9994622751706764 0.006587284216389732 0.0820225570080577 0.030028238471832537 0.007507259698523945 0.040551315179593046 1.1124290922792307e-07 6.95372766197695 -0.8927679072591554 down NLDK(ub)SIDNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLDKSIDNK 9 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;E5RH24;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEQ8;B1ANR1;P0CB38 P11940;B1ANR0;P0CB38 PABPC1;PABPC4;PABPC4L Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4;Polyadenylate-binding protein 4-like 1 78453100.0 30298000.0 39419000.0 8736100.0 True False 25194129.42898062 39206642.02294112 10562778.118837414 1.0 1.5561816546771412 0.419255531278137 24.586584269747547 -6.773688160737503 1.5604115773039398 1.3175036481578501 0.4119603318482593 0.7444525503103447 0.23465303632663 0.26050061100050853 1.2522768419242407 0.1184993989607946 0.28112563170780197 1.6838827162356015e-07 6.773688160737503 -0.9055433163095908 down NLDK(ub)SIDNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLDKSIDNK 9 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;E5RH24;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEQ8;B1ANR1;P0CB38 P11940;B1ANR0;P0CB38 PABPC1;PABPC4;PABPC4L Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4;Polyadenylate-binding protein 4-like 1 108087000.0 35992000.0 52947000.0 19148000.0 True False 46592353.50838713 50000452.90584642 15663260.475071365 1.0 1.0731471827634933 0.33617663190703184 25.47358987100738 -6.882490858070046 1.065838705197499 1.0470154629830357 0.2813938316586519 0.9756385242802955 0.05174386762823255 0.12544525683294414 0.2591626257279561 0.03731030123371958 0.09082260873017745 1.310717632775747e-07 6.882490858070046 -0.7656216313243838 down NLDLSWSELK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLDLSWSELKK 11 1 Q12769;G3V198;E9PR16;Q12769-3 Q12769 NUP160 Nuclear pore complex protein Nup160 1 9662600.0 2366800.0 3245200.0 4050600.0 True False 3102897.720123804 2761028.809690521 3631482.7680988344 1.0 0.889822694374972 1.1703520694694185 21.56518471185561 -6.800220492790963 1.4554944417220068 0.9392269999397894 1.1742241363965873 0.8326638194255074 0.047206611466542744 0.22045184586101996 0.9220641905147525 0.025517524074810574 0.05932361852222287 1.5840887410057893e-07 6.800220492790963 0.23499713645679787 NLDLSWSELK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLDLSWSELKK 11 1 Q12769;G3V198;E9PR16;Q12769-3 Q12769 NUP160 Nuclear pore complex protein Nup160 1 36600100.0 4388100.0 14393000.0 17819000.0 True False 6657068.513081194 11824456.69697771 14297066.839654863 1.0 1.7762257777192103 2.147652050081956 22.666455585555894 -9.923580066875557 0.178690630315562 3.8895023063051705e-15 2.562005979213472 0.99956777336874 0.009940626696513345 1.4413566056085816 0.0808448121745136 0.9577292278594913 0.25754296253387504 1.1923944148092927e-10 9.923580066875557 2.562005979213468 NLDLSWSELK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLDLSWSELKK 11 1 Q12769;G3V198;E9PR16;Q12769-3 Q12769 NUP160 Nuclear pore complex protein Nup160 1 26442000.0 4388100.0 3444900.0 18609000.0 True False 5680481.952382562 3253188.286689524 15222352.944464339 1.0 0.572695822988231 2.6797643355031937 22.437581907648344 -6.853917233301574 1.2161075713907865 0.7709781106455916 2.7705468389087793 0.9458041637998957 0.21172053665269044 0.1532020792474926 0.4340491701443415 0.1360836924934725 0.31578442248894023 1.399854077655964e-07 6.853917233301574 1.9995687282631875 up NLDQQELVK(ub)HCVESHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLDQQELVKHCVESHR 16 1 H3BTX7;Q96A37-2;Q96A37;Q96A37-3 H3BTX7 RNF166 RING finger protein 166 1 17719400.0 7826400.0 5786200.0 4106800.0 True False 10260486.19096541 4922921.5144309485 3681867.7312073046 1.0 0.479794175715152 0.3588394996768547 23.29059575857522 -13.999999999999982 0.20494938102594912 3.9478391015356875 0.28400876392085833 0.9994878064632376 0.006295111834289756 12.633143965122178 0.14352329900982808 14.960663953837674 0.07426939517661506 1.0000000000000409e-14 13.999999999999982 -3.6638303376148293 NLDQQELVK(ub)HCVESHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLDQQELVKHCVESHR 16 1 H3BTX7;Q96A37-2;Q96A37;Q96A37-3 H3BTX7 RNF166 RING finger protein 166 1 16294000.0 7826400.0 4966400.0 3501200.0 True False 10720031.58050741 4746968.026311429 2674288.669477445 1.0 0.4428128770574705 0.24946649171632973 23.35380582009811 -13.99999999999598 0.14761954040509126 3.6848464909155103 0.030813209438415087 0.9995743789525766 0.006564216362282475 11.949591625957819 0.12087578316449989 9.20972669051588 0.1966453908969851 1.0000000000092562e-14 13.99999999999598 -3.654033281477095 NLDQQELVK(ub)HCVESHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLDQQELVKHCVESHR 16 1 H3BTX7;Q96A37-2;Q96A37;Q96A37-3 H3BTX7 RNF166 RING finger protein 166 1 8640200.0 5335400.0 1029900.0 2274900.0 True False 4436621.498296371 1024351.7242808569 2750571.072050825 1.0 0.23088553411062906 0.619969738934688 22.08103004702068 -10.724143851991291 6.676332885261186 1.0082725092290425 0.42542763653262977 0.7440912230261083 0.1588429614659136 0.01952445164726395 0.0008067202778619996 0.15352792983345212 0.051266345368312496 1.8873660905411036e-11 10.724143851991291 -0.5828448726964128 NLDQSGTNVAK(ub)VMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLDQSGTNVAKVMK 14 1 J3KQL8;Q9BQE5 J3KQL8 APOL2 Apolipoprotein L2 1 17092400.0 5838000.0 7309000.0 3945400.0 True False 7653674.535272415 6218525.69025885 3537167.854949182 1.0 0.8124889112543792 0.46215289644835733 22.867721122495226 -6.961354423216134 0.41590574621695414 1.016185227805756 0.2453293508718927 0.9998171786953465 0.0030139096160040906 0.07922080342204739 0.019369528863018102 0.004521440037298823 0.02919699279795428 1.0930639640329487e-07 6.961354423216134 -0.7708558769338633 down NLDQSGTNVAK(ub)VMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLDQSGTNVAKVMK 14 1 J3KQL8;Q9BQE5 J3KQL8 APOL2 Apolipoprotein L2 1 28201600.0 10330000.0 6784600.0 11087000.0 True False 10002079.804356119 9493726.1612216 8182982.097129488 1.0 0.9491752062492922 0.8181280550836663 23.253796685356413 -6.954796454476831 0.5034418423766847 1.0025479680019147 0.7590699286630638 0.999525905433789 0.0016682650484906116 0.08161501656262943 0.02841969497592256 0.001944009814030091 0.01081167244288225 1.1096947861397814e-07 6.954796454476831 -0.24347803933885093 NLDQSGTNVAK(ub)VMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLDQSGTNVAKVMK 14 1 J3KQL8;Q9BQE5 J3KQL8 APOL2 Apolipoprotein L2 1 55824000.0 11025000.0 18787000.0 26012000.0 True False 16725731.035464147 15434313.066499025 20870716.798535384 1.0 0.9227885486005434 1.2478209026728029 23.99556593266813 -6.844036942302135 1.2634497660713255 0.9589200727777911 1.2593990597531743 0.9311812777367008 0.03637338837713982 0.16413895069210319 0.5072045959807463 0.02255731929187193 0.0520399029714772 1.4320660785502952e-07 6.844036942302135 0.3004789869753832 NLDQSGTNVAK(ub)VMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLDQSGTNVAKVMK 14 1 J3KQL8;Q9BQE5 J3KQL8 APOL2 Apolipoprotein L2 1 14903600.0 5838000.0 4895500.0 4170100.0 True False 7996466.366017865 4679200.622746368 3185208.2659053733 1.0 0.585158544858177 0.3983269759554513 22.930931184018117 -13.999999999999998 0.10769963028848749 3.0103008931068174 0.0439556072046533 0.9997547560738158 0.003937651880431118 12.026673495335677 0.0992011620024007 5.280679361220703 0.3149630829941675 1.0000000000000041e-14 13.999999999999998 -2.966345285902164 NLDQSGTNVAK(ub)VMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLDQSGTNVAKVMK 14 1 J3KQL8;Q9BQE5 J3KQL8 APOL2 Apolipoprotein L2 1 25171900.0 10330000.0 10385000.0 4456900.0 True False 8589852.696592843 10329053.943738898 5388817.183622727 1.0 1.2024716032483196 0.6273468677478249 23.03420196079069 -6.811585018629395 1.4080013797789006 1.1101407053182493 0.6169306159381239 0.8638821547336031 0.08788018409146214 0.204654493617589 0.7993578809712983 0.04907428299661633 0.11343204335406755 1.5431742978960084e-07 6.811585018629395 -0.49321008938012534 NLDQSGTNVAK(ub)VMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLDQSGTNVAKVMK 14 1 J3KQL8;Q9BQE5 J3KQL8 APOL2 Apolipoprotein L2 1 43231000.0 11025000.0 11347000.0 20859000.0 True False 14272079.835240262 10715529.475185348 17062876.03141393 1.0 0.7508036389151097 1.19554236161731 23.766692254760578 -6.754663884088396 1.632710021617927 0.854297344119599 1.1967446399966468 0.668775898561533 0.10474690980675443 0.2919617776090737 1.5326349434251543 0.05065259333203046 0.12236871121889814 1.7592846600409806e-07 6.754663884088396 0.3424472958770478 NLDSTTVAVHGEEIYCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLDSTTVAVHGEEIYCK 17 0 P21291;E9PS42;E9PND2 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 14656800.0 5325700.0 1918000.0 7413100.0 False True 6982044.274152168 1631841.8763054414 6646063.5234764 1.0 0.23371978352337167 0.9518793153575976 22.735218074581677 -10.723926449504651 10.16926214200592 1.0006343718928794 0.5927995495842259 0.3000435996545616 0.293187401151651 0.004222416367054812 0.00011462936821529794 0.2842570002841019 0.09462582683151477 1.888311119353633e-11 10.723926449504651 -0.40783482230865353 NLDSTTVAVHGEEIYCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLDSTTVAVHGEEIYCK 17 0 P21291;E9PS42;E9PND2 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 18160500.0 5325700.0 2185800.0 10649000.0 False True 7294755.211630937 2089224.128525998 8133925.523039338 1.0 0.28640085484909594 1.1150374874910687 22.79842813610457 -6.678847674649109 1.9061915595171972 0.54802754733294 1.1118405998033118 0.31878860388062513 0.30251721644456997 0.4410741336368844 3.0976621774348114 0.12739763512409244 0.3364737046325428 2.0948470780380422e-07 6.678847674649109 0.5638130524703718 NLEGYVGFANLPNQVYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLEGYVGFANLPNQVYR 17 0 E7ES33;E7EPK1;Q16181-2;Q16181;A0A5F9ZGZ7;A0A0U1RRD1 E7ES33 SEPT7 Septin-7 0 8087700.0 2324300.0 3472700.0 2290700.0 False True 3047179.8085532184 2954586.696478579 2053680.3379459826 1.0 0.9696135056373316 0.6739609957316752 21.539043202677835 -6.926646927315688 0.7738199895042603 1.0050988308150275 0.6181419296609012 0.9958371914064833 0.009488172126101488 0.0944167149279697 0.08648640847474652 0.008477601930432399 0.027261308221160654 1.184003735793941e-07 6.926646927315688 -0.3869569011541263 NLEGYVGFANLPNQVYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLEGYVGFANLPNQVYR 17 0 E7ES33;E7EPK1;Q16181-2;Q16181;A0A5F9ZGZ7;A0A0U1RRD1 E7ES33 SEPT7 Septin-7 0 16633000.0 5994900.0 3584000.0 7054100.0 False True 5804595.180942351 5015109.890313092 5206419.591536137 1.0 0.8639896037502671 0.8969479230231 22.468764024733375 -10.62391038186521 6.506643134983561 1.0004269730665027 0.8804687633866836 0.946055726312564 0.013455177499696214 8.363340586058165e-05 4.834071847852575e-06 0.013073928491861455 0.004342639864715683 2.377330806263116e-11 10.62391038186521 -0.11995820967981918 NLEGYVGFANLPNQVYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLEGYVGFANLPNQVYR 17 0 E7ES33;E7EPK1;Q16181-2;Q16181;A0A5F9ZGZ7;A0A0U1RRD1 E7ES33 SEPT7 Septin-7 0 40210900.0 5663900.0 23917000.0 10630000.0 False True 8592550.386554679 19648824.485626087 8528975.84070549 1.0 2.286727874924292 0.9926012018563583 23.034654975883274 -6.647497607366466 2.017145895839438 1.8366244444109707 0.998012239456131 0.18393805465632218 0.5495335267630475 0.514804101489363 4.011984259330827 0.22114459335766432 0.6087330350164042 2.251657821638982e-07 6.647497607366466 -0.8386122049548397 NLEGYVGFANLPNQVYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLEGYVGFANLPNQVYR 17 0 E7ES33;E7EPK1;Q16181-2;Q16181;A0A5F9ZGZ7;A0A0U1RRD1 E7ES33 SEPT7 Septin-7 0 11679700.0 2324300.0 3173500.0 6181900.0 False True 3183656.5218457244 3033284.2766388715 4721862.540226954 1.0 0.9527674407791722 1.4831570264651084 21.602253264200726 -6.885175848348258 1.0504775099823391 0.9681195501289982 1.524690106044979 0.9776274811352278 0.03584883469896892 0.12314552706210774 0.24540059092662658 0.02615277096034049 0.0641652170526186 1.3026392254962892e-07 6.885175848348258 0.5565705559159807 NLEGYVGFANLPNQVYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLEGYVGFANLPNQVYR 17 0 E7ES33;E7EPK1;Q16181-2;Q16181;A0A5F9ZGZ7;A0A0U1RRD1 E7ES33 SEPT7 Septin-7 0 12059900.0 5994900.0 2416000.0 3649000.0 False True 4985024.969100137 2402984.5284615466 4411989.028930267 1.0 0.48204062032919304 0.8850485316077944 22.24916930016765 -9.860198265902918 6.487769221293332 1.0000000127509323 0.6835445759684654 0.45118956157532775 0.1645272908230115 3.0333926768316205e-08 5.1224340598794926e-09 0.1593028714598754 0.053100954779496064 1.3797542297255663e-10 9.860198265902918 -0.3164554367824669 NLEGYVGFANLPNQVYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLEGYVGFANLPNQVYR 17 0 E7ES33;E7EPK1;Q16181-2;Q16181;A0A5F9ZGZ7;A0A0U1RRD1 E7ES33 SEPT7 Septin-7 0 24425400.0 5663900.0 11091000.0 7670500.0 False True 7332030.202160297 10473776.100227434 6274547.705976348 1.0 1.428496038810841 0.855772212194056 22.805781297975724 -6.706454907601657 1.807779670708506 1.2643819191936005 0.8572520124063486 0.44823059658838815 0.18066997890410233 0.3822725516396656 2.4329906685316653 0.07959782350196887 0.2030946601286978 1.965826079906099e-07 6.706454907601657 -0.4071299067872519 NLEIK(ub)TDTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLEIKTDTAK 10 1 G3V1J5;Q9Y2L1-2;Q9Y2L1 G3V1J5 DIS3 Exosome complex exonuclease RRP44 1 4576100.0 1504600.0 0.0 3071500.0 True False 1947734.3601000027 0.0 2512518.5162513945 1.0 0.0 1.2899698068284804 20.893365499568386 -6.699762394413143 1.8318467962816711 0.37889506395200273 1.2861015800048772 0.416417240833467 0.42213037214733606 0.3960021430008379 2.5833418888145605 0.1838574718414856 0.47294881730666 1.9963542357840333e-07 6.699762394413143 0.9072065160528744 NLEPEWAAAASEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLEPEWAAAASEVK 14 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 38251600.0 3809600.0 18546000.0 15896000.0 False True 4994422.492218874 15779009.091741804 14251234.405199002 1.0 3.159326051475404 2.8534298865187915 22.25188643737593 -10.299221185250278 5.331662615050518 0.999631789183863 3.0063779689972265 0.9828652485993354 0.12488158640344052 0.0005466763396478794 7.185297891398603e-05 0.12093575015228286 0.04030535869897543 5.020868126553499e-11 10.299221185250278 2.0067461798133635 NLEPEWAAAASEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLEPEWAAAASEVK 14 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 32983700.0 9350900.0 4069800.0 19563000.0 False True 9054060.797923883 5694892.363726623 14438863.42257999 1.0 0.628987643316077 1.5947389513764756 23.110133563624615 -6.802568457056754 1.4454555213996783 0.7959588147767135 1.6089232040219612 0.83955334145781 0.15933280612075212 0.2171115434510229 0.895279242739029 0.08670805226018316 0.20133905826781456 1.575547652431422e-07 6.802568457056754 0.8129643892452477 NLEPEWAAAASEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLEPEWAAAASEVK 14 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 36915600.0 3809600.0 15870000.0 17236000.0 False True 5218112.070568972 15168810.92492799 13165211.786562689 1.0 2.9069538407353552 2.5229837168152622 22.31509649889882 -10.091129276960931 5.385133878851296 0.9999781294420388 2.7149687787764027 0.9637660790536254 0.15675514668341423 4.1161364930702886e-05 6.947105023269071e-06 0.15177944266012577 0.050592506044208556 8.107196940253889e-11 10.091129276960931 1.7149906493343638 NLETPLCK(ub)NGFLLDGFPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLETPLCKNGFLLDGFPR 18 1 P54819;F8W1A4;P54819-2;P54819-5;P54819-3;F8VZG5;A0A5F9ZHP2;A0A5K1VW67;P54819-6;F8VY04;G3V213;P54819-4 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 1 12834400.0 3352600.0 4398200.0 5083600.0 True False 4395291.066624588 3742005.7040493255 4557597.837334528 1.0 0.8513669851045927 1.0369274226097123 22.067527276552124 -6.693392356039374 1.854023483890353 0.9071159929548597 1.036319542222268 0.38648019428126645 0.06281850904067628 0.40943003718906856 2.731128942341324 0.027077022232227375 0.07021920635209544 2.0258516709390346e-07 6.693392356039374 0.1292035492674083 NLETPLCK(ub)NGFLLDGFPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLETPLCKNGFLLDGFPR 18 1 P54819;F8W1A4;P54819-2;P54819-5;P54819-3;F8VZG5;A0A5F9ZHP2;A0A5K1VW67;P54819-6;F8VY04;G3V213;P54819-4 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 1 26221000.0 12954000.0 7072600.0 6194400.0 True False 12542782.360661112 9896726.063121753 4571900.811983308 1.0 0.7890375339814244 0.36450451586583454 23.580354080347654 -6.9599240772823014 0.43650196468314567 1.0157451509663953 0.1213407191701237 0.99976737416044 0.004030791224325625 0.07972824282399366 0.021231561579048597 0.005573869148815533 0.03519943422465171 1.096669897592439e-07 6.9599240772823014 -0.8944044317962716 down NLETPLCK(ub)NGFLLDGFPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLETPLCKNGFLLDGFPR 18 1 P54819;F8W1A4;P54819-2;P54819-5;P54819-3;F8VZG5;A0A5F9ZHP2;A0A5K1VW67;P54819-6;F8VY04;G3V213;P54819-4 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 1 74090000.0 14825000.0 10708000.0 48557000.0 True False 22490608.852676295 8797073.738014141 38959687.666710846 1.0 0.39114431252790755 1.7322646942070132 24.422819381656613 -6.783271903459717 1.5230773023730535 0.6567164336154404 1.7440075513490616 0.7788121917522852 0.2578604694820368 0.24552337175598318 1.1251459319933899 0.1333176807113866 0.31373055431583974 1.647130831563078e-07 6.783271903459717 1.087291117733621 NLETPLCK(ub)NGFLLDGFPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLETPLCKNGFLLDGFPR 18 1 P54819;F8W1A4;P54819-2;P54819-5;P54819-3;F8VZG5;A0A5F9ZHP2;A0A5K1VW67;P54819-6;F8VY04;G3V213;P54819-4 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 1 19896100.0 3352600.0 5040500.0 11503000.0 True False 4592146.8206083495 4817794.043295497 8786228.311721437 1.0 1.0491376324629913 1.9133160708823922 22.130737338075015 -6.918597943296215 0.8350383091369956 0.9799532816653389 2.0482853732569226 0.9937831784618458 0.033071468263589324 0.09900322183983044 0.10993286531848166 0.028285177970739046 0.08362714715734054 1.2061520427675978e-07 6.918597943296215 1.0683320915915837 NLETPLCK(ub)NGFLLDGFPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLETPLCKNGFLLDGFPR 18 1 P54819;F8W1A4;P54819-2;P54819-5;P54819-3;F8VZG5;A0A5F9ZHP2;A0A5K1VW67;P54819-6;F8VY04;G3V213;P54819-4 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 1 27661100.0 12954000.0 5842300.0 8864800.0 True False 10771824.959502786 5810826.37029424 10718388.69379586 1.0 0.539446787535105 0.9950392560306334 23.36075935578193 -10.948529822342596 10.182838868522571 1.0696290042846492 0.7672430217828693 0.2581654589154835 0.18599484641151082 0.10451425050101262 0.0005282772008065172 0.06401773681279474 0.06002957855268232 1.1258231576738725e-11 10.948529822342596 -0.30238598250177995 NLETPLCK(ub)NGFLLDGFPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLETPLCKNGFLLDGFPR 18 1 P54819;F8W1A4;P54819-2;P54819-5;P54819-3;F8VZG5;A0A5F9ZHP2;A0A5K1VW67;P54819-6;F8VY04;G3V213;P54819-4 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 1 69965000.0 14825000.0 14682000.0 40458000.0 True False 19191254.744438734 13864933.793484736 33095059.134136114 1.0 0.722461036452165 1.724486469219864 24.193945703749062 -6.832813743270054 1.3151809888722183 0.8519623673747939 1.7530545115885285 0.911403998332132 0.12573426281604536 0.17736516966062105 0.598979739540243 0.07503790998504123 0.17269411518772068 1.4695563940600901e-07 6.832813743270054 0.9010921442137346 NLFLVIFQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLFLVIFQR 9 0 Q09161;X6R941 Q09161 NCBP1 Nuclear cap-binding protein subunit 1 0 27325400.0 6532100.0 9101300.0 11692000.0 False True 9909673.260476692 7477101.906218542 9381071.075214345 1.0 0.7545255741215897 0.9466579602204848 23.240406059302934 -10.02722784205899 5.459709616644787 1.000000729996896 0.8505917671708889 0.4463764053675078 0.07843771816813824 6.969329926877518e-07 1.241630072832354e-07 0.07594736523682194 0.02531566468156698 9.392304368365872e-11 10.02722784205899 -0.14940896282600713 NLFLVIFQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLFLVIFQR 9 0 Q09161;X6R941 Q09161 NCBP1 Nuclear cap-binding protein subunit 1 0 17280500.0 6532100.0 5291000.0 5457400.0 False True 8455932.216940867 4996551.198837198 4464209.197652738 1.0 0.5908930051292226 0.5279381484053299 23.011532381395384 -13.999999999999995 0.26347782170898876 4.049952902863282 0.5056836741230528 0.999569508710286 0.004342148426689813 14.573595802129422 0.16244601953228055 23.715603143562387 0.02702776854529834 1.0000000000000123e-14 13.999999999999995 -3.5442692287402293 NLFPNTYLIVGVCSDELTHNFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLFPNTYLIVGVCSDELTHNFK 22 0 C9J050;C9JEJ2;P49585;H7C1T3;C9J2E1;C9JPY0 C9J050 PCYT1A Choline-phosphate cytidylyltransferase A 0 104332000.0 30194000.0 38979000.0 35159000.0 False True 45806505.47707976 32022892.905682936 28209808.239262898 1.0 0.6990905019311342 0.6158472021704049 25.4490491698051 -13.999999999999998 0.18029932435767584 2.5627161711060467 0.5499266621078797 0.9994977793093689 0.003697875538244249 12.208642802081648 0.1346093569458388 6.684107824390675 0.06199477451104592 1.0000000000000041e-14 13.999999999999998 -2.012789508998167 NLFPNTYLIVGVCSDELTHNFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLFPNTYLIVGVCSDELTHNFK 22 0 C9J050;C9JEJ2;P49585;H7C1T3;C9J2E1;C9JPY0 C9J050 PCYT1A Choline-phosphate cytidylyltransferase A 0 65110000.0 30194000.0 16674000.0 18242000.0 False True 39086728.21272057 15746077.242376024 14922143.178726343 1.0 0.4028497129941806 0.3817700754464788 25.22017549189755 NLFPSNLVVAAFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLFPSNLVVAAFR 13 0 P43007 P43007 SLC1A4 Neutral amino acid transporter A 0 7614500.0 2795500.0 2915000.0 1904000.0 False True 3664927.5716605117 2480093.3625810076 1706992.3444576554 1.0 0.6767100615462702 0.4657642780329895 21.805353256622222 -8.465814456055043 0.13256287705626402 1.4611064349562524 8.438819650863338e-14 0.9999405577407385 0.0016938694645384598 0.1375426018703252 0.031789283770022166 0.16948978983898727 0.15209206400023506 3.421255778522894e-09 8.465814456055043 -1.461106434956168 NLFPSNLVVAAFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLFPSNLVVAAFR 13 0 P43007 P43007 SLC1A4 Neutral amino acid transporter A 0 13060000.0 2795500.0 3142500.0 7122000.0 False True 3829071.8955469294 3003653.959142168 5439930.282194207 1.0 0.7844339414559721 1.420691601147695 21.868563318145114 -6.815306818007762 1.3921311970141876 0.8832306625415186 1.4332232304016566 0.8732197994756759 0.09407603199704301 0.19965845245454128 0.7615610394911408 0.053120823793399316 0.12260995920298105 1.5300061693222272e-07 6.815306818007762 0.549992567860138 NLFSQTLSLGSQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLFSQTLSLGSQK 13 0 F8WF57;F8WDM4;C9JR33;C9J3U7;F8WCF4;C9JZQ0;B5MCS1;A0A0A0MRF5;E7EWX6;A0A087WYM3;Q8IXJ6-4;Q8IXJ6-2;Q8IXJ6-3;Q8IXJ6 F8WF57 SIRT2 NAD-dependent protein deacetylase sirtuin-2 0 4666740.0 1381700.0 826940.0 2458100.0 False True 1811422.0804018325 703563.7753868732 2203759.39176017 1.0 0.38840410691626315 1.2165907745097733 20.78869131790554 -6.708901070780027 1.7995079734057653 0.623576235182031 1.2145509644391548 0.45973093479975724 0.25776800816294637 0.3772749610277309 2.3808995262437764 0.1140315411654447 0.2900385496750924 1.9547846912286208e-07 6.708901070780027 0.5909747292571238 NLFSQTLSLGSQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLFSQTLSLGSQK 13 0 F8WF57;F8WDM4;C9JR33;C9J3U7;F8WCF4;C9JZQ0;B5MCS1;A0A0A0MRF5;E7EWX6;A0A087WYM3;Q8IXJ6-4;Q8IXJ6-2;Q8IXJ6-3;Q8IXJ6 F8WF57 SIRT2 NAD-dependent protein deacetylase sirtuin-2 0 3923130.0 1381700.0 888430.0 1653000.0 False True 1892551.829038521 849176.2249548683 1262595.444603627 1.0 0.4486937752115766 0.6671391637633868 20.85190137942843 -10.219342599875622 5.488195377001567 1.0000229669857805 0.5579164694874501 0.845222024808275 0.08917995643611003 2.506263783829061e-05 3.5648921911110554e-06 0.0863526009234259 0.028782707174362484 6.034723830913359e-11 10.219342599875622 -0.4421064974983304 NLGHWLGMITLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLGHWLGMITLAK 13 0 A5YKK6-2;A5YKK6;A5YKK6-3;A5YKK6-4 A5YKK6-2 CNOT1 CCR4-NOT transcription complex subunit 1 0 8426200.0 3453600.0 1244800.0 3727800.0 False True 3343967.3584050606 1741855.1315462436 2751377.3483971623 1.0 0.5208947770282779 0.8227883389715442 21.673129334178082 -10.44535829471472 6.262410171968586 1.000110329010749 0.6718415579999122 0.6117148240212 0.12324753056538487 0.00018991359991173189 1.682013090143658e-05 0.11937372569511985 0.03977796944507707 3.5862594470170666e-11 10.44535829471472 -0.32826877101083674 NLGHWLGMITLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLGHWLGMITLAK 13 0 A5YKK6-2;A5YKK6;A5YKK6-3;A5YKK6-4 A5YKK6-2 CNOT1 CCR4-NOT transcription complex subunit 1 0 9875900.0 3453600.0 2590600.0 3831700.0 False True 2871821.4204213964 2576643.92360616 4632890.754220911 1.0 0.8972159289863074 1.6132238311465428 21.45353460961236 -6.870493243842345 1.1315563293630995 0.9416983348528398 1.655538462992385 0.9651692719612391 0.058993798919803955 0.136378982948056 0.326079034079673 0.040450475716811624 0.09584585598407219 1.3474316866747338e-07 6.870493243842345 0.7138401281395452 NLGIPIITVLGDSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLGIPIITVLGDSK 14 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 9187800.0 1795600.0 3755400.0 3636800.0 False True 2354048.9886151375 3195108.958434546 3260498.822648955 1.0 1.3572822714765147 1.3850598855069165 21.166712913021144 -12.030801316675362 0.40018547706682156 4.5665332896602446e-20 1.386884006014085 0.9997413020552519 0.0028201595028394893 5.7661673475795725 0.20406621891984927 4.848013699605258 0.007100328017041689 9.315339410496903e-13 12.030801316675362 1.386884006014085 NLGIPIITVLGDSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLGIPIITVLGDSK 14 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 7152000.0 2444500.0 1568700.0 3138800.0 False True 2366900.6855516513 2195090.090662431 2316654.1180184064 1.0 0.9274111516642801 0.9787711551059296 21.17456774161213 -10.063524985299152 4.7453170808676886 1.0000016880440976 0.9530911533851013 0.5265687294002631 0.02096763360636262 3.744681564095968e-07 7.392510244865212e-08 0.020302554396079996 0.006767274646796694 8.639229570953518e-11 10.063524985299152 -0.046910534658996306 NLGIPIITVLGDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLGIPIITVLGDSK 14 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 12483000.0 1795600.0 4051400.0 6636000.0 False True 2459481.8442654517 3872395.7518118005 5068713.472710018 1.0 1.5744762502885357 2.060886720724641 21.229922974544035 -6.973052176499457 0.17015036405648923 0.5711155182198848 3.0772754361970343 0.9999974514035204 0.0006921927234960156 0.07532419207145728 0.005308250321898676 0.020470311358949094 0.05632660772617103 1.0640151788785396e-07 6.973052176499457 2.5061599179771497 NLGIPIITVLGDSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLGIPIITVLGDSK 14 0 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 5420820.0 2444500.0 989220.0 1987100.0 False True 2032710.0597116384 983890.8755152044 2402593.42268768 1.0 0.4840291269354862 1.1819656282059792 20.954973017046406 -6.708702111078555 1.800074455382872 0.682361509056919 1.1802443445715525 0.45877003537352834 0.217473323112166 0.37771872590340994 2.385044190797548 0.0961767149108175 0.24469712957428252 1.9556804255645002e-07 6.708702111078555 0.4978828355146335 NLGLEELGIELDPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLGLEELGIELDPR 14 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 9152100.0 3314900.0 1037200.0 4800000.0 False True 3209670.313984524 1451359.3689265475 3542736.003086636 1.0 0.45218331696030556 1.1037694393878854 21.61399368573512 -6.683786954629173 1.8887414129182227 0.6545656041765555 1.1013476559771262 0.3413807244408451 0.2319894923562074 0.4301767306074064 2.9702212794281717 0.09844855112996087 0.25836923014387914 2.0711571163016527e-07 6.683786954629173 0.44678205180057073 NLGLEELGIELDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLGLEELGIELDPR 14 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 2677170.0 788670.0 0.0 1888500.0 False True 1080262.612005365 0.0 1442475.1948783738 1.0 0.0 1.3353004897583272 20.042950643733775 -6.706257775997823 1.8084088194920451 0.38289166410138403 1.331849158254157 0.44737782468344933 0.4216491414543699 0.3826463505885738 2.436920868865961 0.18570796547876464 0.47396286685987166 1.9667185950748602e-07 6.706257775997823 0.948957494152773 NLGLYVK(ub)TR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLGLYVKTR 9 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 1 11169200.0 2189100.0 4345900.0 4634200.0 True False 2869931.2992745573 3697508.6601855163 4154697.438385335 1.0 1.2883613838143613 1.447664422990032 21.452584771248763 -11.570687307958716 0.09269283412307375 9.39819347528022e-23 1.8859025682187247 0.99989737080487 0.0018769142466944057 4.625207391443696 0.06386957262594185 1.2517115519525446 0.3094090794467111 2.6872785899563114e-12 11.570687307958716 1.8859025682187247 NLGLYVK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLGLYVKTR 9 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 1 22478300.0 2452500.0 3601800.0 16424000.0 True False 2374646.7299306276 5040017.523138868 12122061.690561438 1.0 2.122428342545969 5.104785287753336 21.179281472710592 -6.954143288063293 0.5113406035475762 0.9457116737692692 6.412641413954692 0.9994875893488965 0.0392101344111602 0.08186347754484406 0.029398087834186945 0.04505858921507326 0.24616363819514972 1.111364990846248e-07 6.954143288063293 5.466929740185423 NLGLYVK(ub)TR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLGLYVKTR 9 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 1 128628800.0 6045800.0 21694000.0 100889000.0 True False 9171920.607184503 17822536.204004344 80948244.92878038 1.0 1.9431629390733804 8.825659138978198 23.128792436223154 -6.931848388970756 0.7314598459495615 0.90218223175537 10.30749525138644 0.9968892131359267 0.19454471981058996 0.09168944492629381 0.0730610341295339 0.17922934188131137 0.6165399899611965 1.1699077313659078e-07 6.931848388970756 9.40531301963107 NLGLYVK(ub)TR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLGLYVKTR 9 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 1 16501100.0 2189100.0 2633500.0 11678500.0 True False 2998469.428203106 2517143.2621800755 8920278.826257378 1.0 0.8394760468471827 2.97494406391298 21.515794832771654 -6.888779808337317 1.029541840898288 0.8818803470193831 3.154304234428285 0.9801068937192523 0.13695934930273104 0.1201400713080694 0.22765938737305597 0.1015173857694168 0.25200550188222115 1.2918741007371578e-07 6.888779808337317 2.2724238874089018 up NLGLYVK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLGLYVKTR 9 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 1 20737600.0 2452500.0 6181300.0 12103800.0 True False 2039362.4141717276 6148000.110008011 14634648.61835194 1.0 3.014667754630055 7.176090192039602 20.95968674814487 -6.959409034173889 0.44368388734314423 0.8567929788004223 9.497209261854263 0.9997476498737784 0.04085201397767855 0.07991290149630918 0.02191644022289847 0.05512717960699271 0.3445690618609334 1.0979712434646097e-07 6.959409034173889 8.64041628305384 NLGLYVK(ub)TR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLGLYVKTR 9 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 1 74202100.0 6045800.0 23900300.0 44256000.0 True False 7826407.280534747 22570227.294947777 36201862.10490696 1.0 2.8838554506462692 4.625604163860156 22.899918758315604 -6.972066235212076 0.2028496206811554 0.0006347286838614282 7.557063959963536 0.9999943305439527 0.003525218547320417 0.07563775997447417 0.006572871221966774 0.055244756387252215 0.1835965864812394 1.0664334647004117e-07 6.972066235212076 7.556429231279674 NLGQNLWGPHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLGQNLWGPHR 11 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 21169200.0 4431500.0 7716700.0 9021000.0 False True 5809739.4147070525 6565398.439461007 8087593.455542292 1.0 1.130067627962976 1.3920750791453695 22.470042024943496 -6.959904410053197 0.43678022038333786 0.9903109439040454 1.5419926133041704 0.9997666330527241 0.0024909100113824334 0.07973530181456254 0.021257740573492657 0.003441105367372891 0.021722667316075667 1.0967195619271321e-07 6.959904410053197 0.551681669400125 NLGQNLWGPHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLGQNLWGPHR 11 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 21038300.0 6460300.0 3721000.0 10857000.0 False True 6255221.312689434 5206814.704758652 8013225.996981586 1.0 0.8323949616612334 1.281045960872054 22.576629497851354 -6.805565810441647 1.4334055326476995 0.9081667163528176 1.288100191592632 0.8478416353912923 0.07220377492483039 0.21291783223285807 0.8630527968743716 0.03962007922908621 0.09183391580740174 1.5647111940909302e-07 6.805565810441647 0.37993347523981436 NLGQNLWGPHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLGQNLWGPHR 11 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 9714100.0 6460300.0 3253800.0 0.0 False True 5372025.689815949 3236271.1335712676 0.0 1.0 0.6024303159432853 0.0 22.35703477328563 -7.645751542040308 0.6632932811597022 0.9981342482014156 3.3796014889502483e-21 0.98725654960102 0.04640711522466883 0.12104192867073733 0.1486311025049298 0.04253612420358974 0.07754864400157613 2.2607287532902412e-08 7.645751542040308 -0.9981342482014156 down NLGVHISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLGVHISR 8 0 Q8WU79;X6RCC3;A0A087WV97;Q8WU79-2;A0A087X1X9;Q8IYB5-3;Q8IYB5-2;Q8IYB5 Q8WU79 SMAP2;SMAP1 Stromal membrane-associated protein 2;Stromal membrane-associated protein 1 0 16537800.0 5532700.0 3956500.0 7048600.0 False True 7253423.278743021 3366205.6223162063 6319278.4869455 1.0 0.464085093748941 0.8712132525706671 22.790230610197007 -9.811417752134885 6.282035078707235 1.0000000113470089 0.6676491731596504 0.4704864147531326 0.1662093748392362 2.651912960370827e-08 4.962543048487427e-09 0.16093153997985604 0.053643845061242354 1.5437687587503032e-10 9.811417752134885 -0.33235083818735844 NLGVHISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLGVHISR 8 0 Q8WU79;X6RCC3;A0A087WV97;Q8WU79-2;A0A087X1X9;Q8IYB5-3;Q8IYB5-2;Q8IYB5 Q8WU79 SMAP2;SMAP1 Stromal membrane-associated protein 2;Stromal membrane-associated protein 1 0 13067700.0 3756300.0 1697500.0 7613900.0 False True 3637058.312594665 2375320.6023455597 5619591.177896114 1.0 0.6530884022728286 1.5450924057049602 21.794340625889422 -6.801226013932384 1.4508059526182486 0.8088920986611201 1.5577970626181874 0.8357608272571987 0.14878987932179777 0.21900448385247345 0.9099199263266238 0.0806748206574403 0.18748958719353725 1.5804253460882374e-07 6.801226013932384 0.7489049639570673 NLGVHISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLGVHISR 8 0 Q8WU79;X6RCC3;A0A087WV97;Q8WU79-2;A0A087X1X9;Q8IYB5-3;Q8IYB5-2;Q8IYB5 Q8WU79 SMAP2;SMAP1 Stromal membrane-associated protein 2;Stromal membrane-associated protein 1 0 15706500.0 4438300.0 7335300.0 3932900.0 False True 6733225.583192801 6026258.40403951 3155560.59114869 1.0 0.8950031941721968 0.4686551121984491 22.682866369560934 -6.9445294706208545 0.6159859451872951 1.0046819223862102 0.3365442871457095 0.998698991329586 0.008287478320133367 0.08575969315583354 0.0456469537846829 0.008376964873135698 0.036028142668407606 1.1362411913007392e-07 6.9445294706208545 -0.6681376352405007 down NLGVHISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLGVHISR 8 0 Q8WU79;X6RCC3;A0A087WV97;Q8WU79-2;A0A087X1X9;Q8IYB5-3;Q8IYB5-2;Q8IYB5 Q8WU79 SMAP2;SMAP1 Stromal membrane-associated protein 2;Stromal membrane-associated protein 1 0 14798200.0 5532700.0 4041800.0 5223700.0 False True 7578288.7055955995 3863219.9115547524 3989969.6454785047 1.0 0.5097747079366688 0.5265000847133762 22.8534406717199 -9.888356377659873 6.906914472603183 1.0000000101133721 0.5181373963443552 0.9990972350169088 0.006828106476472595 1.0660208978405138e-09 1.7116036954178576e-10 0.006611285765885068 0.0022037618891231365 1.2931342730462827e-10 9.888356377659873 -0.48186261376901696 NLGVHISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLGVHISR 8 0 Q8WU79;X6RCC3;A0A087WV97;Q8WU79-2;A0A087X1X9;Q8IYB5-3;Q8IYB5-2;Q8IYB5 Q8WU79 SMAP2;SMAP1 Stromal membrane-associated protein 2;Stromal membrane-associated protein 1 0 10983800.0 3756300.0 4622500.0 2605000.0 False True 3123529.8823051015 4597597.675005592 3149693.4558408763 1.0 1.4719237043484465 1.0083762840509363 21.5747459013237 -10.48183053044538 3.381329427566395 0.9957539580977222 1.2401499943259233 0.2635481224526278 0.18924244230288956 45569703.98193548 55283449.773099795 1739685.6077936455 0.06925563915179608 3.2973835694138066e-11 10.48183053044538 0.24439603622820116 NLGVHISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLGVHISR 8 0 Q8WU79;X6RCC3;A0A087WV97;Q8WU79-2;A0A087X1X9;Q8IYB5-3;Q8IYB5-2;Q8IYB5 Q8WU79 SMAP2;SMAP1 Stromal membrane-associated protein 2;Stromal membrane-associated protein 1 0 17112700.0 4438300.0 7013500.0 5660900.0 False True 5745466.841972512 6623192.559638018 4630674.285739064 1.0 1.152768389724823 0.8059700652887727 22.453992691653383 -6.786939941936382 1.5083517072197106 1.0857214165556726 0.8025763127688053 0.7913345212413918 0.06482595063763487 0.2399323646116501 1.0783991345027133 0.03383380999345881 0.07939967684867412 1.6332777963076086e-07 6.786939941936382 -0.2831451037868673 NLHQSGFSLSGAQIDDNIPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLHQSGFSLSGAQIDDNIPR 20 0 A0A1C7CYX9;Q16555-2;Q16555 A0A1C7CYX9 DPYSL2 Dihydropyrimidinase-related protein 2 0 9029500.0 1946000.0 3443000.0 3640500.0 False True 2551224.8450908083 2929317.8207088863 3263815.982141857 1.0 1.1482005697559832 1.2793133417551383 21.28275862177407 -6.972569321726589 0.18688952796228128 0.9074450628954952 1.5236391575613484 0.9999961029194525 0.00022517168291172077 0.07547748418553359 0.005940486181485353 0.004754027626984074 0.014418240227626153 1.0651988239404182e-07 6.972569321726589 0.6161940946658532 NLHQSGFSLSGAQIDDNIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLHQSGFSLSGAQIDDNIPR 20 0 A0A1C7CYX9;Q16555-2;Q16555 A0A1C7CYX9 DPYSL2 Dihydropyrimidinase-related protein 2 0 8386900.0 1946000.0 2951200.0 3489700.0 False True 2665488.788672625 2820806.225686672 2665504.732627509 1.0 1.0582697768882354 1.0000059816251907 21.345968683296963 -6.646133624833066 2.022207608779508 1.037925771552638 1.0002495343538242 0.1786011207550301 0.024893838018588264 0.518050156168253 4.056023793389636 0.00999877374498921 0.027571502925999906 2.2587406882024234e-07 6.646133624833066 -0.037676237198813745 NLHSPEYLEMALPLFCKAMSK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLHSPEYLEMALPLFCKAMSK 21 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 25503100.0 7608300.0 7139800.0 10755000.0 True False 9849094.33201437 6742463.853611395 8797700.355619006 1.0 0.6845770409259958 0.893249679518469 23.231559637773017 -10.315488227329459 4.938857921906187 1.0000878517831064 0.788913361467612 0.5770526955044349 0.08519024797227671 8.24428248738514e-05 1.1426314287375617e-05 0.08251934939166422 0.02749503430461389 4.83628374117114e-11 10.315488227329459 -0.2111744903154944 NLIDAGVDGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLIDAGVDGLR 11 0 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 5789810.0 758110.0 2915900.0 2115800.0 False True 993889.5515476842 2480859.0860891747 1896877.3121867152 1.0 2.496111446413721 1.9085393434641695 19.922726012051516 -9.92167729039247 5.71710832910142 0.9999991775296063 2.202325394940377 0.8480914423388516 0.23987530655847555 2.5150234929398103e-06 4.7399877388247496e-07 0.23225842257784388 0.07741942228821005 1.1976301193743352e-10 9.92167729039247 1.2023262174107705 NLIDAGVDGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLIDAGVDGLR 11 0 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 5680310.0 758110.0 2469500.0 2452700.0 False True 1038403.7541524176 2360389.3244555513 1873422.774942116 1.0 2.2730939820052805 1.8041371359171086 19.985936073574408 -10.28307165002644 5.192083794627978 0.9998031648053528 2.038615558961365 0.8673752967964439 0.19145083071741487 0.0004362985106321675 6.0244101410699175e-05 0.18540555250458532 0.061790489915424796 5.2110873134693006e-11 10.28307165002644 1.038812394156012 NLILELKPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLILELKPR 9 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;E7ERV5 G3V394 MYO5A Unconventional myosin-Va 0 6265700.0 1570700.0 2154800.0 2540200.0 False True 2059202.910680437 1833312.2393446148 2277364.471318981 1.0 0.8903018880926215 1.1059446640770605 20.973654567244292 -6.768389557227913 1.5804165547464364 0.9369524086876128 1.1070906015926767 0.7244629349776892 0.046213751893699875 0.26902728986091307 1.3258459971049967 0.02305140460112368 0.05495788462258162 1.7045527385792728e-07 6.768389557227913 0.17013819290506393 NLILELKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLILELKPR 9 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;E7ERV5 G3V394 MYO5A Unconventional myosin-Va 0 4268600.0 1570700.0 1041700.0 1656200.0 False True 2151430.236571475 995674.2495587567 1265039.6705096946 1.0 0.4627964377527137 0.5879993917560931 21.036864628767184 -9.963928715311734 7.078851721352446 1.0000000219854135 0.5253979147545151 0.9503939334511678 0.05111389193290775 1.7726363338253918e-08 2.708664862788317e-09 0.04949081526640361 0.016496937684666087 1.0866039631341333e-10 9.963928715311734 -0.47460210723089835 NLILKPGGSLDGMDMLHNFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLILKPGGSLDGMDMLHNFLK 21 1 E9PCB6;Q9BYT8;H0YAK4 E9PCB6 NLN Neurolysin, mitochondrial 0 40250700.0 15547800.0 8121700.0 16581200.0 False True 15054243.599435443 11364737.164105972 12238086.294662545 1.0 0.7549191753833562 0.812932660072107 23.843666885873727 -10.120481073436965 5.056726756977717 1.0000077110864412 0.783925917727251 0.9487083618884316 0.023683905949704532 33038952.124721218 1.6535864908728448 2966.379946662751 0.008107630961298403 7.577377543742528e-11 10.120481073436965 -0.2160817933591902 NLILKPGGSLDGMDMLHNFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLILKPGGSLDGMDMLHNFLK 21 1 E9PCB6;Q9BYT8;H0YAK4 E9PCB6 NLN Neurolysin, mitochondrial 0 29487600.0 15547800.0 6184500.0 7755300.0 False True 12928684.58432587 6151182.87097286 9376897.373544227 1.0 0.47577793632851595 0.7252785318092095 23.624072161308003 -10.41311267171567 6.063096236518636 1.0001104413579822 0.6005282340688646 0.7736514959755934 0.10185819157470935 0.00015210484558464302 1.4723225802449329e-05 0.09865080011085221 0.03287458997030446 3.862667524702568e-11 10.41311267171567 -0.39958220728911764 NLILVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLILVVR 7 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 10787500.0 5207900.0 2074500.0 3505100.0 False True 5042578.065160332 2902858.6683745855 2587009.1592539516 1.0 0.575669554514331 0.5130330410009618 22.26573008298599 -13.999999999999998 0.2694147896446948 4.264870139480314 0.49212351566515694 0.999582071193966 0.004422121252839331 14.854361521789432 0.1643053661332708 26.553346923783973 0.026090456211033113 1.0000000000000041e-14 13.999999999999998 -3.7727466238151566 NLILVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLILVVR 7 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 36895800.0 8378800.0 15090000.0 13427000.0 False True 12711252.172330812 12397071.601291856 10773147.56473685 1.0 0.975283271326892 0.8475284274658066 23.59960281995415 -6.939071089758997 0.66818484461278 1.0014596760934178 0.8140024481057117 0.9980391940169621 0.0029586875357614606 0.08819380589147635 0.0565664578691128 0.002860111825728943 0.011041434706184445 1.1506120295930758e-07 6.939071089758997 -0.18745722798770614 NLILVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLILVVR 7 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 33348800.0 8378800.0 14224000.0 10746000.0 False True 10846521.770840026 13432421.896099113 8790338.263271209 1.0 1.238408236289265 0.810429227819678 23.3707291420466 -6.7555755268586815 1.6297112237386637 1.1392452228450314 0.8092299164737495 0.6724074842263488 0.10021998115135068 0.29041885220213637 1.5192494168562636 0.04855126550264069 0.11716455897423012 1.755595557260002e-07 6.7555755268586815 -0.33001530637128185 NLIQK(ub)DR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLIQKDR 7 1 J3QT51;J3QT87;A0A1W2PPJ5;Q96SW2-2;Q96SW2 J3QT51 CRBN Protein cereblon 1 2408770.0 365710.0 553960.0 1489100.0 True False 479449.3515406778 471311.32731916767 1335022.2164558265 1.0 0.9830263109223965 2.7844906081650205 18.871018893141144 -6.904772304897907 0.9305932387108227 0.934589407242141 2.993040861011923 0.9887949554139935 0.08947257983645597 0.10797757168620588 0.1582664978239972 0.07140944934481765 0.19066608937923524 1.2451672661107783e-07 6.904772304897907 2.0584514537697816 up NLIQK(ub)DR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLIQKDR 7 1 J3QT51;J3QT87;A0A1W2PPJ5;Q96SW2-2;Q96SW2 J3QT51 CRBN Protein cereblon 1 3730840.0 382480.0 973760.0 2374600.0 True False 370338.38175896707 1362587.446091317 1752621.0235269864 1.0 3.6793038831663702 4.732485504750278 18.49848455217696 -9.169044719205486 0.3284218338993196 7.815831084666546e-19 5.085087930128465 0.9983791091971055 0.06325879218103737 0.5876361868791097 0.12173346243943392 1.0544920907022948 0.3275692536241809 6.775717346087977e-10 9.169044719205486 5.085087930128465 NLIQK(ub)DR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLIQKDR 7 1 J3QT51;J3QT87;A0A1W2PPJ5;Q96SW2-2;Q96SW2 J3QT51 CRBN Protein cereblon 1 2650570.0 365710.0 381860.0 1903000.0 True False 500922.8699411435 364988.1625578452 1453550.5935152478 1.0 0.7286314609686914 2.901745319965196 18.934228954664036 -6.875600619532714 1.103995018428791 0.8398549814053429 3.0433551769352274 0.969962341632122 0.16756352293468124 0.1316006555936548 0.29641652641022603 0.11734145611217597 0.2808590502511258 1.3316784765935998e-07 6.875600619532714 2.2035001955298847 up NLIQK(ub)DR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLIQKDR 7 1 J3QT51;J3QT87;A0A1W2PPJ5;Q96SW2-2;Q96SW2 J3QT51 CRBN Protein cereblon 1 2335420.0 382480.0 807740.0 1145200.0 True False 318049.0667369634 803388.544296163 1384656.0251934633 1.0 2.5259893152291206 4.353592479925802 18.278889827611238 -6.968727765107819 0.28694992945500186 0.6296175779606531 6.306190657874 0.9999706889339534 0.007422240690965281 0.07671770825428056 0.010500475456910702 0.032462841300923945 0.16632903476810712 1.0746628472125523e-07 6.968727765107819 5.6765730799133465 NLK(ub)ASLENSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLKASLENSLR 11 1 P05783;F8VZY9;CON__H-INV:HIT000015463 P05783 KRT18 Keratin, type I cytoskeletal 18 1 15224000.0 2132100.0 3402000.0 9689900.0 True False 2795203.7472857703 2894434.8608921384 8687282.100084167 1.0 1.0355004939095136 3.107924461148776 21.41452201678814 -6.910617850512883 0.8915174943198722 0.9370807601257445 3.379319708293579 0.99115263142232 0.09268944114422843 0.10401083953657257 0.13656182649168133 0.07611867448224079 0.21103222854878384 1.2285197691929856e-07 6.910617850512883 2.4422389481678346 up NLK(ub)ASLENSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLKASLENSLR 11 1 P05783;F8VZY9;CON__H-INV:HIT000015463 P05783 KRT18 Keratin, type I cytoskeletal 18 1 46540700.0 5027200.0 13745900.0 27767600.0 True False 4867614.287750154 19234709.553921547 20494432.549855936 1.0 3.9515681434183576 4.210364942315224 22.214783422010825 -10.086702187948996 0.5504680586474515 7.433607693010741e-23 4.190859199524838 0.999475224085355 0.033359055078702765 1.370923356290828 0.2579529210644549 2.296767266496089 0.04810467747954247 8.190262326852301e-11 10.086702187948996 4.190859199524838 NLK(ub)ASLENSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLKASLENSLR 11 1 P05783;F8VZY9;CON__H-INV:HIT000015463 P05783 KRT18 Keratin, type I cytoskeletal 18 1 182148400.0 4993200.0 26683200.0 150472000.0 True False 7575049.451816747 21921374.483206846 120731143.24577959 1.0 2.8938919306921984 15.938000670982323 22.852823876214437 -6.932990792721743 0.7218183824333404 0.8219704834694577 18.83196472658495 0.9970941318198125 0.3579694903376369 0.09111429839117216 0.0702880676834633 0.33213584655830297 1.1614668145902125 1.1668343543190818e-07 6.932990792721743 18.009994243115493 NLK(ub)ASLENSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLKASLENSLR 11 1 P05783;F8VZY9;CON__H-INV:HIT000015463 P05783 KRT18 Keratin, type I cytoskeletal 18 1 12542300.0 2132100.0 5788400.0 4621800.0 True False 2920394.987836023 5532649.348320923 3530226.028958884 1.0 1.8944866606624842 1.20881800018933 21.477732078311032 -10.20576132178219 4.767472801027875 0.9999098155262827 1.5516523304278522 0.4632486695278173 0.2799230584696789 0.000268381739512575 4.4711475006333555e-05 0.27107837126226114 0.09034477863840122 6.226423810300877e-11 10.20576132178219 0.5517425149015696 NLK(ub)ASLENSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLKASLENSLR 11 1 P05783;F8VZY9;CON__H-INV:HIT000015463 P05783 KRT18 Keratin, type I cytoskeletal 18 1 30282300.0 5027200.0 11856500.0 13398600.0 True False 4180339.5427213497 11792626.681169014 16200185.311873155 1.0 2.820973406742018 3.875327625020391 21.9951886974451 -8.639959022361522 0.2401146875098255 5.372201480458342e-23 4.735037423916615 0.9993600165210292 0.03004563963670175 0.23438944750988586 0.06900112859799222 0.6171634306985629 0.4371718365236023 2.2910838166364416e-09 8.639959022361522 4.735037423916615 NLK(ub)ASLENSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLKASLENSLR 11 1 P05783;F8VZY9;CON__H-INV:HIT000015463 P05783 KRT18 Keratin, type I cytoskeletal 18 1 169213600.0 4993200.0 28962400.0 135258000.0 True False 6463795.830686778 27350616.98000427 110642431.86427857 1.0 4.231355336156753 17.117253508999344 22.623950198306886 -6.944945618518055 0.6118314917977102 0.8578226826477984 21.16394864875231 0.9987424806252176 0.2468912757393216 0.08558123253487447 0.04486830887559058 0.2505259449906352 1.0872749256307466 1.1351529483434952e-07 6.944945618518055 20.30612596610451 NLK(ub)LEGTEDLSDVLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLKLEGTEDLSDVLVR 16 1 E9PHA2;Q15003;Q15003-2;H7C415 E9PHA2 NCAPH Condensin complex subunit 2 1 22035300.0 3492500.0 5634800.0 12908000.0 True False 4521110.0974672735 5321218.426612717 10558876.447264528 1.0 1.1769716533985015 2.335461030506559 22.10824561972516 -6.934020740113912 0.7130203677306189 0.9847364801839021 2.5996249610286113 0.9972710961739089 0.030938652332056126 0.09060316205505382 0.06784310785649457 0.028893965275135602 0.10260469692735824 1.1640704368783239e-07 6.934020740113912 1.614888480844709 up NLK(ub)LGIHEDSTNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLKLGIHEDSTNR 13 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 10664100.0 2720400.0 3128600.0 4815100.0 True False 3566470.744391072 2661825.0751872803 4316879.641700662 1.0 0.7463470937967142 1.2104065758817018 21.766065708567538 -6.758307349385876 1.619044396037176 0.8523529290790888 1.211949644587799 0.6839405980293147 0.1066620898372738 0.28577067686170715 1.4760293306795018 0.0519915331816415 0.12514347514850607 1.7445870749577705e-07 6.758307349385876 0.3595967155087103 NLK(ub)LGIHEDSTNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLKLGIHEDSTNR 13 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 18718400.0 3402200.0 5469800.0 9846400.0 True False 3294199.0232701227 7653919.664630178 7267332.454331729 1.0 2.3234539293355136 2.2060999966897903 21.65149628929767 -10.139186086832725 6.129345145869752 0.9999933044492505 2.2647769630126624 0.9935844563991206 0.04790954238186777 4.3836259257079965e-06 6.156464552506983e-07 0.046388459910870754 0.015462738314110136 7.257949016430361e-11 10.139186086832725 1.2647836585634118 NLK(ub)LGIHEDSTNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLKLGIHEDSTNR 13 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 53667000.0 9078000.0 11984000.0 32605000.0 True False 13771989.690697815 9845361.568580627 26160607.458720803 1.0 0.7148830190622784 1.899551774743978 23.715233670273776 -6.843160208262175 1.267697872540118 0.8483343429141431 1.9410031834375399 0.9297429887876553 0.13381758920731238 0.16514049870764422 0.5141610401922849 0.08272760837680515 0.19077448198240002 1.4349599887860538e-07 6.843160208262175 1.0926688405233969 NLK(ub)LGIHEDSTNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLKLGIHEDSTNR 13 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 12146400.0 2720400.0 3163200.0 6262800.0 True False 3726205.3960457356 3023439.3646964193 4783655.626414755 1.0 0.8113990087355103 1.283787423927621 21.82927577009043 -6.798391361540822 1.4627743769493555 0.8957268710704797 1.290029810343697 0.8273270769569925 0.08067796253843758 0.22306704402821956 0.9425112083404661 0.043395730288372465 0.10100940611743729 1.5907745651940984e-07 6.798391361540822 0.39430293927321725 NLK(ub)LGIHEDSTNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLKLGIHEDSTNR 13 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 17909500.0 3402200.0 8098600.0 6408700.0 True False 2829080.0430153096 8054971.234353752 7748729.53951916 1.0 2.847205138023789 2.7389573365553685 21.431901564731945 -10.196316740828978 4.593627145388493 0.9996354318482461 2.7930812373070535 0.9972740741524472 0.04419197995559631 0.00016502927357079476 2.8872939216592148e-05 0.04279674474835217 0.01426290019192061 6.363312607904632e-11 10.196316740828978 1.7934458054588074 NLK(ub)LGIHEDSTNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLKLGIHEDSTNR 13 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 1 50766000.0 9078000.0 11741000.0 29947000.0 True False 11751649.954132518 11087603.028831525 24496953.28216851 1.0 0.9434933028219176 2.0845543713250287 23.486359992366225 -6.895252515395624 0.9908063644411429 0.9461839461932037 2.1934161803976413 0.9840522873775338 0.0663105445919051 0.11498425791092375 0.19778749442309332 0.05060955647586311 0.12880350960825795 1.2727628329208417e-07 6.895252515395624 1.2472322342044375 up NLK(ub)NEITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLKNEITK 8 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 17508500.0 4619200.0 6014100.0 6875200.0 True False 6055815.932396428 5116819.722778194 6163820.255575258 1.0 0.8449430728904848 1.0178348094434386 22.529889924341578 -6.670290905599022 1.9361038804416366 0.9010540921050886 1.0171405365076591 0.2804361080797291 0.06586010787016157 0.4604510952051743 3.3277774851391593 0.027381195078881718 0.07313427480429376 2.136530487410882e-07 6.670290905599022 0.11608644440257054 NLK(ub)NEITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLKNEITK 8 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 24132000.0 4344100.0 8432900.0 11355000.0 True False 4206198.92334012 11800200.946992537 8380784.8573018415 1.0 2.8054310226540737 1.9924841906066355 22.0040856502379 -10.14954322803995 5.112839874764984 0.999937258657933 2.3989576066320324 0.7979153741581972 0.33188415442722075 0.00023737001271970781 3.948276726970489e-05 0.32135968438429674 0.10711515024639116 7.086907625263039e-11 10.14954322803995 1.3990203479740995 NLK(ub)NEITK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLKNEITK 8 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 15630600.0 5364200.0 4735800.0 5530600.0 True False 8137883.575549826 3890659.4890257125 4437474.485851906 1.0 0.47809230162927774 0.5452860617451256 22.95622220999896 -10.43576471106547 6.015923639306172 1.0001969245823947 0.5116891816875285 0.9859976045185537 0.027431737697134254 7.248182945286475e-05 6.79806555589083e-06 0.02657117755428442 0.008853555271544186 3.666361543438627e-11 10.43576471106547 -0.4885077428948662 NLK(ub)NEITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLKNEITK 8 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 15826600.0 4619200.0 4543200.0 6664200.0 True False 6327043.06918632 4342466.40164668 5090253.213507257 1.0 0.6863342566443343 0.804523243772052 22.59309998586447 -10.175965968217815 5.491819330793987 1.0000075921234328 0.7454287504756565 0.8608387309921258 0.04825045194666286 4.4853499038632514e-06 6.730223956595743e-07 0.04671969181198811 0.015572766403016969 6.668590229557427e-11 10.175965968217815 -0.25457884164777633 NLK(ub)NEITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLKNEITK 8 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 21737600.0 4344100.0 11488000.0 5905500.0 True False 3612311.626260309 11426111.86381055 7140312.746053082 1.0 3.163102480070241 1.9766602344452713 21.784490925672177 -10.322519545120208 5.8945106946359695 0.9998406136838381 2.56988135725776 0.7000978653175767 0.4843630185105137 0.001014643785475285 0.00011661610910457907 0.4690278690472588 0.15632749201749588 4.7586137469768504e-11 10.322519545120208 1.5700407435739216 NLK(ub)NEITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLKNEITK 8 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 12851500.0 5364200.0 4094500.0 3392800.0 True False 6944062.644190101 3866637.4756452283 2775345.213067795 1.0 0.5568264103838887 0.3996716843258675 22.72734853209141 -13.999999999999998 0.1444290656518968 3.1266997314453437 0.2151845385253435 0.9995858817244891 0.005172654702689599 11.941138825685742 0.11937315587289572 7.141365497843985 0.16546886181639886 1.0000000000000041e-14 13.999999999999998 -2.91151519292 NLK(ub)SLDLFNCEITNLEDYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLKSLDLFNCEITNLEDYR 19 1 Q9BTT0;E9PPH5;Q9BTT0-3;Q9BTT0-2 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 182898000.0 20993000.0 44541000.0 117364000.0 True False 31847915.79387745 36592310.549578644 94166953.95753132 1.0 1.1489703372241795 2.9567697480421713 24.924695626262228 -6.923232960951793 0.8003881337853336 0.9645664690109236 3.271128874704891 0.9950328133235902 0.06268331879383558 0.09630654989679525 0.09603072243558058 0.054954345569886896 0.17006456995971864 1.193347806169187e-07 6.923232960951793 2.3065624056939678 up NLK(ub)SLDLFNCEITNLEDYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLKSLDLFNCEITNLEDYR 19 1 Q9BTT0;E9PPH5;Q9BTT0-3;Q9BTT0-2 Q9BTT0 ANP32E Acidic leucine-rich nuclear phosphoprotein 32 family member E 1 180616000.0 20993000.0 22762000.0 136861000.0 True False 27175852.333895586 21495274.69059393 111953702.31244741 1.0 0.790969660362172 4.119602246028217 24.695821948354677 -6.8919336294703895 1.010849745028663 0.8293514489352686 4.417007978684318 0.9821081680034641 0.2036176791702827 0.11758923521988775 0.21278410223640226 0.1530752511284798 0.38438296932366617 1.2825265682536325e-07 6.8919336294703895 3.58765652974905 up NLLALIHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLLALIHR 8 0 E7ET15;O15042-2;O15042;O15042-3 E7ET15 U2SURP U2 snRNP-associated SURP motif-containing protein 0 24035200.0 6153200.0 7891500.0 9990500.0 False True 8066904.787673555 6714118.960826074 8956778.895642964 1.0 0.8323042278973499 1.110311715756105 22.94358379746861 -6.743387984860438 1.6743596314568039 0.9006152101838654 1.1105961049587645 0.6200338750140935 0.07045560194036979 0.311716403487334 1.7171402849282433 0.03327229269663846 0.081343435534772 1.8055603751386383e-07 6.743387984860438 0.20998089477489912 NLLALIHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLLALIHR 8 0 E7ET15;O15042-2;O15042;O15042-3 E7ET15 U2SURP U2 snRNP-associated SURP motif-containing protein 0 22281700.0 6894500.0 6623700.0 8763500.0 False True 6675637.871358501 9268577.952139175 6468076.45063537 1.0 1.388418325072059 0.9689076272975107 22.670474265282138 -6.6634323568807226 1.960557880074844 1.2493083922366268 0.9706387815925903 0.2503551736759331 0.16524464440156397 0.47636244666361804 3.523360922841674 0.06800789401008218 0.183276952127445 2.1705392474944506e-07 6.6634323568807226 -0.2786696106440365 NLLALIHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLLALIHR 8 0 E7ET15;O15042-2;O15042;O15042-3 E7ET15 U2SURP U2 snRNP-associated SURP motif-containing protein 0 21083700.0 6153200.0 5379700.0 9550800.0 False True 8428204.323977582 5142007.065711088 7295097.7449003775 1.0 0.6100952074788315 0.8655577706091433 23.0067938589915 -10.148636395461786 5.128315401745367 1.0000112856798056 0.7378264890436932 0.5840796049988826 0.1042921546764913 1.345780986674241e-05 2.23410919055732e-06 0.1009847892563597 0.03366014818336438 7.101720967947597e-11 10.148636395461786 -0.2621847966361124 NLLALIHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLLALIHR 8 0 E7ET15;O15042-2;O15042;O15042-3 E7ET15 U2SURP U2 snRNP-associated SURP motif-containing protein 0 16097300.0 6894500.0 3826300.0 5376500.0 False True 5733082.228137406 3805686.9624389154 6500701.291872731 1.0 0.6638116829653998 1.133892910164087 22.450879540716414 -6.714663843366917 1.7781324229138007 0.7943203602940496 1.1329708570196393 0.4874645039750758 0.14156847501845346 0.36575666615474706 2.25691911410778 0.06328507078118659 0.15989805151098607 1.9290174514177907e-07 6.714663843366917 0.33865049672558967 NLLALIHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLLALIHR 8 0 E7ET15;O15042-2;O15042;O15042-3 E7ET15 U2SURP U2 snRNP-associated SURP motif-containing protein 0 13576200.0 2985700.0 6457500.0 4133000.0 False True 3865047.506945751 6098134.448401294 3380836.408161163 1.0 1.5777644226733396 0.8747205311410977 21.882054716362738 -6.688321948731945 1.872164388703813 1.3627825841499102 0.8771831487416766 0.36269619900892147 0.24443643475420035 0.4202757226094307 2.8546339285806996 0.10449539785766103 0.2727117518041771 2.0496421863321441e-07 6.688321948731945 -0.4855994354082336 NLLCVHVNVSGNELCLMTSHLESTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLLCVHVNVSGNELCLMTSHLESTR 25 0 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 0 49183400.0 13814000.0 14911600.0 20457800.0 False True 20956847.938675907 12250508.475137442 16414306.863027709 1.0 0.5845587328297164 0.7832431151411406 24.32091840564752 -10.13705651371963 4.926956418615318 1.0000158569596986 0.6839009239874733 0.7714220544632711 0.08111255943135318 1.5777113469403705e-05 2.7632371854117107e-06 0.07854129400433137 0.02617896598555405 7.29362593839933e-11 10.13705651371963 -0.31611493297222537 NLLCVHVNVSGNELCLMTSHLESTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLLCVHVNVSGNELCLMTSHLESTR 25 0 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 0 69879000.0 23878000.0 20574000.0 25427000.0 False True 30910541.705747597 19429038.814000476 20799546.903052002 1.0 0.628557046943884 0.6728949334195743 24.881595601789996 -10.621448667159607 9.988655118022407 1.0000578026249856 0.6507259903276927 0.988058431614183 0.01810086635648138 2.3303828742385007e-05 8.83161194252988e-07 0.017528958102991918 0.005842029495881539 2.3908445122411514e-11 10.621448667159607 -0.3493318122972928 NLLEIHGSLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLLEIHGSLFK 11 0 Q9NXA8-4;Q9NXA8-3;Q9NXA8-2;Q9NXA8 Q9NXA8-4 SIRT5 NAD-dependent protein deacylase sirtuin-5, mitochondrial 0 4940860.0 1977300.0 1139300.0 1824260.0 False True 2592259.4482004414 969320.8809566174 1635503.074737567 1.0 0.3739289605558288 0.6309179723013223 21.305778687971188 -10.34027709042913 5.818330658929361 1.0000721728506257 0.502423466428609 0.8332883649975037 0.10491532471310022 9.823701191608375e-05 1.1138735934728143e-05 0.10159846433560307 0.03386127544798102 4.567966492613353e-11 10.34027709042913 -0.49764870642201664 NLLEIHGSLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLLEIHGSLFK 11 0 Q9NXA8-4;Q9NXA8-3;Q9NXA8-2;Q9NXA8 Q9NXA8-4 SIRT5 NAD-dependent protein deacylase sirtuin-5, mitochondrial 0 6643100.0 3350500.0 1692700.0 1599900.0 False True 3244140.21147098 2368603.937313885 1180838.194028815 1.0 0.7301176222096444 0.36399110921700617 21.629404743386907 -6.966873046131672 0.32430096890768556 1.0476764199138802 0.03454785324233369 0.9999467116278493 0.0019026241347530211 0.07733097826298191 0.012648740259484079 0.005456320715980328 0.03208540480783097 1.0792621682886396e-07 6.966873046131672 -1.0131285666715464 down NLLEIHGSLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLLEIHGSLFK 11 0 Q9NXA8-4;Q9NXA8-3;Q9NXA8-2;Q9NXA8 Q9NXA8-4 SIRT5 NAD-dependent protein deacylase sirtuin-5, mitochondrial 0 23595300.0 6937800.0 10266700.0 6390800.0 False True 10525149.821119573 8434527.170906767 5127655.578812858 1.0 0.8013688464540618 0.48718124358893194 23.327337433811792 -6.964360144340829 0.36886894847787355 1.024473194405614 0.2531599019083216 0.9998993413052069 0.002118150725558388 0.07817876671148274 0.015629640316348302 0.004148486451944548 0.026700068720684523 1.085525064507226e-07 6.964360144340829 -0.7713132924972924 down NLLEIHGSLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLLEIHGSLFK 11 0 Q9NXA8-4;Q9NXA8-3;Q9NXA8-2;Q9NXA8 Q9NXA8-4 SIRT5 NAD-dependent protein deacylase sirtuin-5, mitochondrial 0 12741000.0 1977300.0 3527400.0 7236300.0 False True 2708361.2445233227 3371547.804448071 5527234.976276608 1.0 1.2448663601525838 2.0408041901550003 21.36898874949408 -6.949635250669119 0.5628348204473109 0.9897405468592861 2.334154640163714 0.9991723401143768 0.012782559040535948 0.08363256512979642 0.036571230498268784 0.013655729590766176 0.066205512121557 1.1229611957034418e-07 6.949635250669119 1.3444140933044277 up NLLEIHGSLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLLEIHGSLFK 11 0 Q9NXA8-4;Q9NXA8-3;Q9NXA8-2;Q9NXA8 Q9NXA8-4 SIRT5 NAD-dependent protein deacylase sirtuin-5, mitochondrial 0 22508000.0 6937800.0 10449600.0 5120600.0 False True 8981118.864483448 9868070.574063363 4188703.341792907 1.0 1.0987573734367815 0.4663899236828352 23.09846375590424 -6.866989738595057 1.1498362468318826 1.054960410578083 0.4314039098101528 0.961588845799602 0.05443853599991524 0.1397773733538133 0.34727255206925145 0.03680500351614726 0.08671420484832607 1.358345540867788e-07 6.866989738595057 -0.6235565007679302 down NLLGLALGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLLGLALGR 9 0 Q8N5L8 Q8N5L8 RPP25L Ribonuclease P protein subunit p25-like protein 0 6151000.0 1845500.0 1730800.0 2574700.0 False True 2419468.371847421 1472571.386605559 2308294.7422663514 1.0 0.6086342783977603 0.9540503893852593 21.206258649238567 -10.236706982967766 7.821528407099344 1.0000002342322514 0.7813423338915098 0.3482358301606474 0.14101553680932244 5.758863977451052e-07 5.618699042089312e-08 0.1365378528914969 0.04551256880158373 5.798197669396626e-11 10.236706982967766 -0.21865790034074162 NLLGLALGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLLGLALGR 9 0 Q8N5L8 Q8N5L8 RPP25L Ribonuclease P protein subunit p25-like protein 0 6605500.0 2238900.0 1559200.0 2807400.0 False True 2167827.3450118992 2181796.691120584 2072057.7198052981 1.0 1.0064439385086767 0.9558223004119937 21.047818428223483 -6.8749407770609325 1.1075680882106749 1.0037801153600758 0.9525646219125554 0.9693729769481588 0.003937407175108067 0.132208836826705 0.3001377204635747 0.0027497277027080692 0.006572339846021013 1.333703291355206e-07 6.8749407770609325 -0.05121549344752041 NLLGLALGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLLGLALGR 9 0 Q8N5L8 Q8N5L8 RPP25L Ribonuclease P protein subunit p25-like protein 0 7979800.0 1845500.0 2596100.0 3538200.0 False True 2527831.2227622424 2481395.717845336 2702550.0315163624 1.0 0.9816302985346606 1.0691180673697032 21.26946871076146 -6.851873678015652 1.2259548855480829 0.990178851663729 1.0727450677852386 0.9429921452261707 0.008993362965811144 0.1554114782038332 0.448531807464533 0.0057372195831285454 0.013293632388251502 1.406456556605302e-07 6.851873678015652 0.0825662161215096 NLLGLALGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLLGLALGR 9 0 Q8N5L8 Q8N5L8 RPP25L Ribonuclease P protein subunit p25-like protein 0 4536490.0 2238900.0 818790.0 1478800.0 False True 1861744.5500872915 814379.015752909 1788010.2428013398 1.0 0.43742790369104356 0.9603950459892607 20.82822370365776 -10.618989724029099 9.558400669347309 1.0000686823786475 0.6989114748401526 0.30649722248168587 0.21350044181201894 0.000312557351661939 1.245879434859512e-05 0.20676759709842085 0.06890697129548959 2.4044196910232878e-11 10.618989724029099 -0.30115720753849495 NLLHVTDTGVGMTR ddPTM_RPMI8226_Bortezomib_1h_R1 2 NLLHVTDTGVGMTR 14 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 101225000.0 21646000.0 36084000.0 43495000.0 False True 28378115.62016221 30700407.854330365 38994554.63350093 1.0 1.0818339126266088 1.374106552931087 24.75827545813059 -6.947480439347106 0.5858603739855092 0.9965776760845019 1.4739651184596374 0.9989883669983805 0.005107458999838477 0.08451370108028414 0.040274457203592816 0.005317951658087482 0.024455343336374273 1.1285467662059133e-07 6.947480439347106 0.47738744237513553 NLLHVTDTGVGMTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLLHVTDTGVGMTR 14 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 62014700.0 20647000.0 9121700.0 32246000.0 False True 19991572.286596388 12764042.379037093 23799805.240735777 1.0 0.6384711615501555 1.1904919182716143 24.25288860507216 -6.730076590645912 1.723640997688677 0.7824431962431702 1.1901257248963257 0.5593290868778875 0.1519766223687049 0.3360881728718744 1.956318258597429 0.06988211238506717 0.17334700319609533 1.8617587744860987e-07 6.730076590645912 0.4076825286531556 NLLHVTDTGVGMTR ddPTM_RPMI8226_Bortezomib_8h_R1 2 NLLHVTDTGVGMTR 14 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 172314000.0 15659700.0 140088000.0 16566300.0 False True 23756909.777420245 115088201.88746022 13291963.54373276 1.0 4.8444096040153255 0.5594988434213825 24.501843851413522 -6.670230069484088 1.9364607339838982 3.4534023881698204 0.5767763780342077 0.2800620423502056 1.632938806231292 0.46061807593531834 3.3301953050925297 0.6788007774730965 1.8131054700975544 2.1368297942725385e-07 6.670230069484088 -2.8766260101356127 NLLHVTDTGVGMTR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NLLHVTDTGVGMTR 14 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 112602100.0 21646000.0 42523000.0 48433100.0 False True 29649111.161155023 40644193.25524334 36994199.29100536 1.0 1.370840192622489 1.2477338389649113 24.821485519653482 -10.01386855607823 4.995601635092999 0.999996344898249 1.3092870157926095 0.8937967952859003 0.050257958436931253 2.0513270613718004e-06 4.0498345881853094e-07 0.04866263539414901 0.01622068633514672 9.685709603795391e-11 10.01386855607823 0.3092906708943606 NLLHVTDTGVGMTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLLHVTDTGVGMTR 14 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 38305300.0 20647000.0 9943200.0 7715100.0 False True 17168895.31718803 9889634.008029325 9328291.739408031 1.0 0.5760204034868027 0.5433250985035329 24.033293880506438 -13.999999999999996 0.36339144466709233 6.666085493772174 0.5395774627570469 0.9997793725698283 0.0030895438519736294 22.067920862019875 0.195100715402539 97.12025353441754 0.009331519150961599 1.0000000000000082e-14 13.999999999999996 -6.126508031015128 NLLHVTDTGVGMTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLLHVTDTGVGMTR 14 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 35732000.0 10117000.0 12294000.0 13321000.0 False True 13096655.935884433 11609828.092705462 10896714.685002392 1.0 0.8864727110143354 0.8320226734479396 23.642695149211185 -13.99999999961598 0.09722906488717045 1.5655187529856514 0.7109021022321295 0.99980750852675 0.0009708374886840384 12.102085865151325 0.09228833946067229 1.3833701019863491 0.10820858951158636 1.0000000008842386e-14 13.99999999961598 -0.8546166507535219 NLLIWIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLLIWIK 7 0 Q9BTM9-3;Q9BTM9;Q9BTM9-2 Q9BTM9-3 URM1 Ubiquitin-related modifier 1 0 9617300.0 1515300.0 6130000.0 1972000.0 False True 1986572.974186074 5215427.894552848 1767956.3567597137 1.0 2.6253391958529386 0.8899528885839543 20.921850359257956 -6.66084625958374 1.9693429362899282 2.0454132174418342 0.8970659882369488 0.23954952819204245 0.6918781819035615 0.48235395617848587 3.596898424444753 0.28371807725471554 0.7673216338810359 2.1835027358664573e-07 6.66084625958374 -1.1483472292048855 NLLIWIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLLIWIK 7 0 Q9BTM9-3;Q9BTM9;Q9BTM9-2 Q9BTM9-3 URM1 Ubiquitin-related modifier 1 0 19001400.0 11756000.0 4039200.0 3206200.0 False True 11382812.21490907 5652073.62414973 2366400.0360617456 1.0 0.49654457241653455 0.20789238998094545 23.440353695255325 -8.704920039493947 0.25025162414581603 1.265634147963856 5.848994111362459e-21 0.9992609819555007 0.008898046570442047 0.2678869167407 0.07362498434140026 0.17222129178004983 0.11243491384432033 1.9727859238747615e-09 8.704920039493947 -1.265634147963856 NLLIWIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLLIWIK 7 0 Q9BTM9-3;Q9BTM9;Q9BTM9-2 Q9BTM9-3 URM1 Ubiquitin-related modifier 1 0 91272000.0 20588000.0 37930000.0 32754000.0 False True 31233501.184411444 31161095.151557323 26280157.543411803 1.0 0.9976817830179647 0.8414092735952432 24.89659096454242 -6.910128304965106 0.8948607277094701 1.0048188943167957 0.8211581615799374 0.9909698878632005 0.007052895349985334 0.10433322584857473 0.13830752498401472 0.005777965078847836 0.015964008913317788 1.229905362379658e-07 6.910128304965106 -0.18366073273685835 NLLIWIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLLIWIK 7 0 Q9BTM9-3;Q9BTM9;Q9BTM9-2 Q9BTM9-3 URM1 Ubiquitin-related modifier 1 0 19422500.0 1515300.0 5917200.0 11990000.0 False True 2075547.3594427682 5655758.538436286 9158208.941801256 1.0 2.7249479578026654 4.412430725868863 20.985060420780847 -6.971394755951143 0.22236445337287178 0.2446721953547526 6.94048804145569 0.9999913127536331 0.004106176215238526 0.07585268025835612 0.007389525129940792 0.04590721796081125 0.17018917066608694 1.0680835934850008e-07 6.971394755951143 6.695815846100937 NLLIWIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLLIWIK 7 0 Q9BTM9-3;Q9BTM9;Q9BTM9-2 Q9BTM9-3 URM1 Ubiquitin-related modifier 1 0 18802200.0 11756000.0 2714100.0 4332100.0 False True 9775634.879104123 2699478.6045933333 5237922.0806327285 1.0 0.27614355875377417 0.5358140054748805 23.2207589706896 -10.302199002391497 5.672748583456383 1.0000653660643486 0.40597878211515737 0.8746468793617124 0.10601001595790041 8.764803580827563e-05 1.0781406693834263e-05 0.10265497510062897 0.034214585528007824 4.986559410063064e-11 10.302199002391497 -0.5940865839491912 NLLIWIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLLIWIK 7 0 Q9BTM9-3;Q9BTM9;Q9BTM9-2 Q9BTM9-3 URM1 Ubiquitin-related modifier 1 0 84292000.0 20588000.0 32805000.0 30899000.0 False True 26651571.85015209 30979372.9120874 25275699.0505134 1.0 1.1623844584577705 0.9483755477022329 24.66771728663487 -6.703842112047929 1.8175177394822883 1.100453123109206 0.9489711881568702 0.4357196689111271 0.06849747300251907 0.38755658605161875 2.4916287815444447 0.03003879971756663 0.07687757880547501 1.977688498966694e-07 6.703842112047929 -0.15148193495233586 NLLQVDLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLLQVDLTK 9 0 P22694-2;P22694-4;A0A0A0MS54;A0A087WVC4;P22694-5;P22694-6;P22694-7;P22694-9;P22694;P22694-3;P22694-10;P17612;P17612-2 P22694-2;P17612 PRKACB;PRKACA cAMP-dependent protein kinase catalytic subunit beta;cAMP-dependent protein kinase catalytic subunit alpha 0 7636900.0 2362000.0 2149500.0 3125400.0 False True 3096604.873640541 1828802.9786853741 2802013.588953757 1.0 0.5905832527271494 0.9048663627721912 21.562255876390118 -9.785610209387494 6.012594150699325 1.0000000125962596 0.7477248077491391 0.46210647820164863 0.12830554239944528 2.1660515157615453e-08 4.3103977584374495e-09 0.12423131278752793 0.04141043574465313 1.638286266369516e-10 9.785610209387494 -0.2522752048471205 NLLQVDLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLLQVDLTK 9 0 P22694-2;P22694-4;A0A0A0MS54;A0A087WVC4;P22694-5;P22694-6;P22694-7;P22694-9;P22694;P22694-3;P22694-10;P17612;P17612-2 P22694-2;P17612 PRKACB;PRKACA cAMP-dependent protein kinase catalytic subunit beta;cAMP-dependent protein kinase catalytic subunit alpha 0 6621900.0 1854600.0 1182400.0 3584900.0 False True 1795726.7381567126 1654538.4861345433 2645907.1453052694 1.0 0.9213754247669682 1.4734464264987526 20.776136396296007 -6.8708048743618315 1.1298881286710827 0.9553127512469675 1.5062685881048476 0.9654769221535167 0.04530617058355751 0.13608240334374885 0.32421653690818336 0.031104801907762093 0.07374334699318862 1.3464651760722031e-07 6.8708048743618315 0.5509558368578802 NLLQVDLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLLQVDLTK 9 0 P22694-2;P22694-4;A0A0A0MS54;A0A087WVC4;P22694-5;P22694-6;P22694-7;P22694-9;P22694;P22694-3;P22694-10;P17612;P17612-2 P22694-2;P17612 PRKACB;PRKACA cAMP-dependent protein kinase catalytic subunit beta;cAMP-dependent protein kinase catalytic subunit alpha 0 9468100.0 2362000.0 2402000.0 4704100.0 False True 3235295.2306499197 2295871.6976482053 3593088.463980591 1.0 0.7096328260549505 1.1105905977114787 21.62546593791301 -6.712472360567335 1.7865399590388567 0.8219364273989491 1.1097116079767244 0.47672017848935844 0.12231353061671067 0.3701531513839177 2.3045152672200744 0.05445364142287726 0.13791701707171145 1.9387760198917642e-07 6.712472360567335 0.2877751805777753 NLLQVDLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLLQVDLTK 9 0 P22694-2;P22694-4;A0A0A0MS54;A0A087WVC4;P22694-5;P22694-6;P22694-7;P22694-9;P22694;P22694-3;P22694-10;P17612;P17612-2 P22694-2;P17612 PRKACB;PRKACA cAMP-dependent protein kinase catalytic subunit beta;cAMP-dependent protein kinase catalytic subunit alpha 0 3267640.0 1854600.0 774870.0 638170.0 False True 1542182.0727106556 770695.6215103468 771608.3964353056 1.0 0.49974360041399907 0.5003354727623492 20.556541671730283 -9.981360008390244 5.006153019635693 1.000003891904765 0.5000395365809208 0.9999989482959025 0.00024163090388409572 332440.52156437794 0.008896600578914142 15.23703013471191 8.271668088851354e-05 1.0438545572892424e-10 9.981360008390244 -0.4999643553238441 NLLSVAYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLLSVAYK 8 0 P61981;P27348;E9PG15;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2;P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1;P31947-2;P31947;Q04917;A2IDB2;P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917;P62258 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH;YWHAE 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta;14-3-3 protein epsilon 0 675770000.0 191810000.0 179640000.0 304320000.0 False True 251464767.49068204 152838412.23123562 272831885.64356816 1.0 0.6077925498525316 1.084970623782029 27.905781038544564 -6.688303772154466 1.8722868653418385 0.7537222627988232 1.0832952036245267 0.36255072440151836 0.16593358920961573 0.4203346695150921 2.855408823886242 0.07093237160143114 0.18511938756884713 2.0497279720402196e-07 6.688303772154466 0.32957294082570354 NLLSVAYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLLSVAYK 8 0 P61981;P27348;E9PG15;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2;P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1;P31947-2;P31947;Q04917;A2IDB2;P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917;P62258 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH;YWHAE 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta;14-3-3 protein epsilon 0 515530000.0 150390000.0 114140000.0 251000000.0 False True 145615951.7693241 159716697.2322367 185255570.1614057 1.0 1.0968351701278591 1.2722203021745604 27.117593165994855 -6.961937086140868 0.40721627655799747 0.9910936648647218 1.384441102812485 0.999835426747326 0.0014453255886730043 0.07901631302868424 0.0186271247838206 0.002257019921267497 0.014656817468632632 1.0915984588757415e-07 6.961937086140868 0.39334743794776317 NLLSVAYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLLSVAYK 8 0 P61981;P27348;E9PG15;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2;P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1;P31947-2;P31947;Q04917;A2IDB2;P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917;P62258 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH;YWHAE 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta;14-3-3 protein epsilon 0 458589000.0 141450000.0 221030000.0 96109000.0 False True 214589991.3801727 181585469.5847277 77113014.0239288 1.0 0.8461972919465129 0.35935046890101024 27.67700754850686 -6.950238384542546 0.5562216856894393 1.006497738580546 0.17593328270697386 0.9992198490458843 0.007627176608528602 0.08339018705273665 0.035567493219140316 0.008213719275518932 0.040437751999299616 1.1214027465902958e-07 6.950238384542546 -0.8305644558735722 down NLLSVAYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLLSVAYK 8 0 P61981;P27348;E9PG15;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2;P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1;P31947-2;P31947;Q04917;A2IDB2;P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917;P62258 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH;YWHAE 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta;14-3-3 protein epsilon 0 566770000.0 191810000.0 177990000.0 196970000.0 False True 262727340.4703471 170125813.2657801 150449742.72448668 1.0 0.6475375305867014 0.5726459319199301 27.968991100067456 -13.999999999999996 0.21769370152110729 3.105659369767536 0.5316901167732659 0.999495689162246 0.004184385385793355 12.93791152759509 0.14782681627267294 11.697237751706952 0.04208654687960617 1.0000000000000082e-14 13.999999999999996 -2.57396925299427 NLLSVAYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLLSVAYK 8 0 P61981;P27348;E9PG15;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2;P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1;P31947-2;P31947;Q04917;A2IDB2;P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917;P62258 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH;YWHAE 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta;14-3-3 protein epsilon 0 324919000.0 150390000.0 115050000.0 59479000.0 False True 125055948.40664071 114430202.8143629 71915783.9001764 1.0 0.9150320658260382 0.5750688777020825 26.89799844142913 -6.944868371584156 0.6125985702891741 1.0037473549679825 0.4685702067053306 0.9987345392735797 0.0065310464001858 0.08561413752320224 0.04501118077486003 0.006622428662636291 0.028693025394693084 1.135354873275149e-07 6.944868371584156 -0.535177148262652 NLLSVAYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLLSVAYK 8 0 P61981;P27348;E9PG15;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2;P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1;P31947-2;P31947;Q04917;A2IDB2;P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917;P62258 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH;YWHAE 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta;14-3-3 protein epsilon 0 392294000.0 141450000.0 152300000.0 98544000.0 False True 183109813.39634788 143824371.11754036 80610003.14682654 1.0 0.7854541952168738 0.4402276516570045 27.44813387059931 -6.964064143014025 0.37376644791682934 1.0254400803254922 0.1881534974079996 0.9998925339602551 0.0023904498841224938 0.07827999480608967 0.015988594884680542 0.004525965535917783 0.029261842532492068 1.086265176107377e-07 6.964064143014025 -0.8372865829174926 down NLLSVAYK(ub)NVIGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLLSVAYKNVIGAR 14 1 P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 1 130605000.0 32073000.0 49300000.0 49232000.0 True False 42048013.59537377 41944632.16989489 44137944.90669083 1.0 0.9975413481722653 1.049703449286056 25.32553431145072 -6.895837674185333 0.9871854843310257 0.9975767467142505 1.0547389528653184 0.9843798770313129 0.0030033897167506957 0.11453508308356285 0.19519170917091655 0.0022984291253697058 0.005864651103137905 1.2710490951853543e-07 6.895837674185333 0.05716220615106793 NLLSVAYK(ub)NVIGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLLSVAYKNVIGAR 14 1 P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 1 301033000.0 44390000.0 92260000.0 164383000.0 True False 42980863.74785752 129099899.12954395 121326160.91570659 1.0 3.0036599517146567 2.822794851854376 25.357191139816447 -9.886840158890822 6.848545447567086 0.9999999545357012 2.913227401784542 0.9933421121718723 0.07383786782262886 5.139794787838286e-08 8.244464263299795e-09 0.07149320916437897 0.02383106936636168 1.297656782770968e-10 9.886840158890822 1.9132274472488409 NLLSVAYK(ub)NVIGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLLSVAYKNVIGAR 14 1 P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 1 749454000.0 152034000.0 220400000.0 377020000.0 True False 230646693.17421857 181067898.0069403 302501831.7462636 1.0 0.785044413665931 1.3115376924904334 27.781109367455837 -6.795859964802982 1.4727403705526387 0.8807662505684902 1.3180840397603368 0.8197592960099019 0.0917626353948656 0.22673763735378938 0.9712758422739156 0.049026835385345816 0.11431865754368667 1.6000738779970777e-07 6.795859964802982 0.4373177891918466 NLLSVAYK(ub)NVIGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLLSVAYKNVIGAR 14 1 P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 1 161564000.0 32073000.0 57353000.0 72138000.0 True False 43931254.84023482 54818954.818991475 55100490.12874556 1.0 1.2478349416230436 1.2542434840327232 25.388744372973612 -12.071146842213743 0.5562176316832257 2.7658757649181937e-06 1.2536404672537078 0.9999469696554255 0.0008619734677298324 7.697118472478849 0.2761268603107035 9.183019947157856 0.001186639260205384 8.488934014777712e-13 12.071146842213743 1.253637701377943 NLLSVAYK(ub)NVIGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLLSVAYKNVIGAR 14 1 P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 1 310991000.0 44390000.0 130803000.0 135798000.0 True False 36912251.8104314 130098338.27663726 164192733.9409901 1.0 3.5245299838324002 4.448190665371145 25.137596415250723 -9.293729567074068 0.3307987988895307 2.8434333556510326e-24 4.73858443416524 0.9984186702369006 0.057955311243952576 0.6866970402860024 0.1271269521835107 1.1134127107484668 0.2864563755662396 5.084759693547317e-10 9.293729567074068 4.73858443416524 NLLSVAYK(ub)NVIGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLLSVAYKNVIGAR 14 1 P62258;P62258-2;B4DJF2;I3L3T1;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 1 645801000.0 152034000.0 180267000.0 313500000.0 True False 196811010.03817877 170234982.98257166 256446216.78164193 1.0 0.8649667665927241 1.3030074726606744 27.552235689548287 -6.823926193553506 1.35464915335118 0.9274880411959145 1.3134108417174817 0.8931874330860295 0.059860592685725474 0.18844338312163722 0.6783702375614092 0.03471312019951824 0.07994294512194101 1.4999397220345548e-07 6.823926193553506 0.38592280052156713 NLLSVAYK(ub)NVVGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLLSVAYKNVVGAR 14 1 P61981;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2;P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;Q04917;A2IDB2 P61981;P31946;P31946-2;P63104;Q04917 YWHAG;YWHAB;YWHAZ;YWHAH 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein eta 1 279228000.0 35413000.0 130609000.0 113206000.0 True False 46426785.939979844 111122646.30989459 101492529.06863101 1.0 2.393502889766115 2.1860770030438825 25.468454072857835 -10.160298965615208 4.724340713890366 0.9998608496876935 2.289789946414548 0.9809714554238333 0.08468126368507414 0.00012412563698652374 2.206188699085093e-05 0.08200093263124061 0.027330760327696418 6.913548826763171e-11 10.160298965615208 1.2899290967268544 NLLSVAYK(ub)NVVGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLLSVAYKNVVGAR 14 1 P61981;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2;P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;Q04917;A2IDB2 P61981;P31946;P31946-2;P63104;Q04917 YWHAG;YWHAB;YWHAZ;YWHAH 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein eta 1 481757000.0 153550000.0 157252000.0 170955000.0 True False 148675639.29902044 220043543.65834647 126176756.95993271 1.0 1.4800241969418337 0.8486713597118801 27.14759303835459 -6.703425581397978 1.8184851641544966 1.297068574878966 0.8504139927414981 0.43390151765373897 0.2025000902587779 0.38845227973140967 2.4996489364696157 0.08875564695228996 0.227310080305313 1.9795862044943934e-07 6.703425581397978 -0.446654582137468 NLLSVAYK(ub)NVVGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLLSVAYKNVVGAR 14 1 P61981;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2;P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;Q04917;A2IDB2 P61981;P31946;P31946-2;P63104;Q04917 YWHAG;YWHAB;YWHAZ;YWHAH 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein eta 1 658150000.0 246300000.0 125500000.0 286350000.0 True False 373655106.9419336 103103544.4640246 229752796.9883365 1.0 0.275932384031478 0.6148793171025503 28.47713199960957 -10.591547708044768 6.522199241266489 1.0012021760042393 0.44540585056874227 0.7811649578901471 0.13837450598423465 0.002423362874320025 0.00015176288591588089 0.13422707687414864 0.0446601797680516 2.5612518904193585e-11 10.591547708044768 -0.5557963254354971 NLLSVAYK(ub)NVVGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLLSVAYKNVVGAR 14 1 P61981;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2;P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;Q04917;A2IDB2 P61981;P31946;P31946-2;P63104;Q04917 YWHAG;YWHAB;YWHAZ;YWHAH 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein eta 1 195077000.0 35413000.0 52834000.0 106830000.0 True False 48506143.10034104 50499619.18132607 81598954.23291317 1.0 1.0410973941354453 1.6822395889962949 25.531664134380726 -6.919950714718102 0.8250732560974899 0.9858297884364675 1.7855193107050058 0.9941678833781528 0.02385554439912758 0.09819993855678445 0.10575732328401294 0.020548893302810893 0.061526506341266184 1.2024008796019726e-07 6.919950714718102 0.7996895222685383 NLLSVAYK(ub)NVVGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLLSVAYKNVVGAR 14 1 P61981;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2;P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;Q04917;A2IDB2 P61981;P31946;P31946-2;P63104;Q04917 YWHAG;YWHAB;YWHAZ;YWHAH 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein eta 1 461446000.0 153550000.0 175132000.0 132764000.0 True False 127683628.4183766 174188529.1550197 160524338.56862092 1.0 1.3642197618653356 1.257203766505102 26.927998313788866 -10.13966965653644 4.548289634238482 0.9999620400691791 1.310711764192125 0.9182989987186163 0.043689097181627404 5114091.159107712 11401032.891853426 1175.7653853878821 0.014955940763309458 7.249872075190769e-11 10.13966965653644 0.310749724122946 NLLSVAYK(ub)NVVGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLLSVAYKNVVGAR 14 1 P61981;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2;P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;Q04917;A2IDB2 P61981;P31946;P31946-2;P63104;Q04917 YWHAG;YWHAB;YWHAZ;YWHAH 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein eta 1 642420000.0 246300000.0 234670000.0 161450000.0 True False 318840205.29883677 221610408.2084913 132067756.61689354 1.0 0.6950516419370145 0.4142129957955317 28.248258321702018 -7.1286974378991195 0.21649498692155703 1.1450872144283528 3.4997301113452055e-12 0.9999888668547234 0.0007981495301951085 0.08002905971907155 0.008621307809617723 0.010404892718309099 0.03216520310148711 7.435369610983983e-08 7.1286974378991195 -1.1450872144248532 down NLLSVAYK(ub)NVVGGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLLSVAYKNVVGGQR 15 1 P31947-2;P31947 P31947-2 SFN 14-3-3 protein sigma 1 6748800.0 1273600.0 3326100.0 2149100.0 True False 1669701.933559944 2829858.8450362566 1926731.7476228746 1.0 1.6948287524604833 1.153937543520071 20.671159152649246 -10.210414255746759 3.6531805161967994 0.9994491300753283 1.4243831480996196 0.4507896012125421 0.22081791284229838 74423027.8250167 110068094.80581747 456986.7727681639 0.08586658302373965 6.160071375179696e-11 10.210414255746759 0.4249340180242913 NLLSVAYK(ub)NVVGGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLLSVAYKNVVGGQR 15 1 P31947-2;P31947 P31947-2 SFN 14-3-3 protein sigma 1 12041000.0 2004600.0 4974000.0 5062400.0 True False 1940965.0702625634 6960144.1390673425 3736405.5712553766 1.0 3.5859193169951333 1.925024632591629 20.888342724772755 -10.393798476788758 6.185396306590323 0.9996875400023989 2.75547197479337 0.5983139323861097 0.678057415548249 0.00292214488404433 0.0002863853302084978 0.6566300008346763 0.2188420898492342 4.038327377184184e-11 10.393798476788758 1.755784434790971 NLLSVAYK(ub)NVVGGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLLSVAYKNVVGGQR 15 1 P31947-2;P31947 P31947-2 SFN 14-3-3 protein sigma 1 7959700.0 1273600.0 4517500.0 2168600.0 True False 1744484.3377458649 4317901.912625216 1656421.343718949 1.0 2.4751737915885172 0.9495191833360301 20.734369214172137 -6.653836604294684 1.994898879030705 1.9543227157236447 0.9559337392327376 0.20974933174649535 0.6290303753233714 0.4991850047699544 3.812084999696975 0.2553479545040472 0.6968761160790755 2.219031134432262e-07 6.653836604294684 -0.9983889764909071 NLLSVAYK(ub)NVVGGQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLLSVAYKNVVGGQR 15 1 P31947-2;P31947 P31947-2 SFN 14-3-3 protein sigma 1 9835600.0 2004600.0 6773000.0 1058000.0 True False 1666913.7188373683 6736512.504664759 1279222.908360709 1.0 4.041308454383177 0.7674199893518998 20.66874800020703 -6.662689915856272 1.9631927692037816 2.9532464333250754 0.7809250374387846 0.24723846699781027 1.2940800506108607 0.47804682388131636 3.544567580730774 0.5320188799965551 1.435158649620229 2.1742530308591655e-07 6.662689915856272 -2.172321395886291 NLLSVAYK(ub)NVVGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLLSVAYKNVVGGR 14 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 94547900.0 18839500.0 52770000.0 22938400.0 True False 24698766.941977505 44896921.6958489 20564954.408669893 1.0 1.817779883559411 0.8326308133916649 24.557935682900077 -6.686306358369832 1.8793202482270772 1.5144499737528108 0.8361573998167466 0.3533089858570392 0.34612533721328964 0.4246479887998829 2.9047915306540495 0.14749171402918268 0.3859077607360076 2.05917682409165e-07 6.686306358369832 -0.6782925739360641 NLLSVAYK(ub)NVVGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLLSVAYKNVVGGR 14 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 190129000.0 55095000.0 68382000.0 66652000.0 True False 53346039.382478304 95687289.20741896 49193841.682860576 1.0 1.7937093421568573 0.9221648364586644 25.66887782794417 -6.667041003380855 1.9481186126065602 1.5079039911694447 0.9257460579224797 0.2659638937406803 0.33738165357969124 0.4679047504827156 3.4206998563731483 0.13957335210346233 0.37431492737178534 2.1525784920718388e-07 6.667041003380855 -0.5821579332469651 NLLSVAYK(ub)NVVGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLLSVAYKNVVGGR 14 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 213455000.0 66482000.0 86850000.0 60123000.0 True False 100858054.48523602 71350938.93785278 48239662.69715296 1.0 0.7074391758002571 0.47829261572970816 26.587751060718624 -7.303832595236383 0.16045104203123642 1.2551435701906273 2.8119352639019967e-12 0.9999917305320737 0.0006139567061246781 0.108382683563726 0.009585700302671925 0.02310007012419328 0.04728241693484879 4.967837766676585e-08 7.303832595236383 -1.2551435701878153 down NLLSVAYK(ub)NVVGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLLSVAYKNVVGGR 14 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 90876500.0 18839500.0 26297000.0 45740000.0 True False 25804972.268344223 25135111.587449968 34937154.04486987 1.0 0.9740414105495476 1.3538923305772501 24.621145744422968 -6.890532693003756 1.0192520113959829 0.9798499671053454 1.386902884165316 0.9812361362317179 0.023734649519790086 0.11871097643820251 0.21934429559638507 0.017730859659221176 0.04428784233063574 1.2866703908658363e-07 6.890532693003756 0.4070529170599705 NLLSVAYK(ub)NVVGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLLSVAYKNVVGGR 14 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 186937730.0 55095000.0 92106730.0 39736000.0 True False 45813933.62234106 91610532.76373562 48044613.88149447 1.0 1.9996216329929364 1.0486899963129475 25.449283103378445 -6.634510986133624 2.064585176634571 1.6564186285224294 1.0526186535326538 0.1337350284013168 0.42830434456652516 0.5473971885055161 4.452462177200639 0.16935263899388578 0.47423209570512104 2.320005496790846e-07 6.634510986133624 -0.6037999749897756 NLLSVAYK(ub)NVVGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLLSVAYKNVVGGR 14 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 181281100.0 66482000.0 92343000.0 22456100.0 True False 86062259.55613993 87204030.87397905 18369320.21904381 1.0 1.0132668061903989 0.21344222559089537 26.358877382811073 -6.903129271913153 0.9412693588686623 1.0304592660333307 0.12394007509988765 0.9880599683061084 0.04086202731527259 0.10913851980481305 0.16471237045748524 0.03235711303492461 0.08558990904771062 1.2498869340214287e-07 6.903129271913153 -0.906519190933443 down NLMFLVLR ddPTM_RPMI8226_Bortezomib_1h_R1 2 NLMFLVLR 8 0 O43776;K7EQ35;K7EPK2;K7EMQ6 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 36405000.0 9349400.0 14256000.0 12799600.0 False True 12257153.939718384 12129060.369452767 11475220.17443289 1.0 0.9895494850684269 0.9362059276459198 23.54712069432382 -6.939346943274344 0.6656277152969295 1.0006060390205131 0.9220938489973847 0.9980768547275419 0.0012251396229915027 0.0880661423867628 0.055979399340753355 0.0011867503681924755 0.0046045510190555455 1.1498814202827003e-07 6.939346943274344 -0.07851219002312848 NLMFLVLR ddPTM_RPMI8226_Bortezomib_2h_R1 2 NLMFLVLR 8 0 O43776;K7EQ35;K7EPK2;K7EMQ6 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 31885600.0 13047800.0 10477200.0 8360600.0 False True 12633604.731004616 14660800.597876195 6170708.047376281 1.0 1.1604606056651874 0.48843605437745796 23.5907630044885 -6.843714265989273 1.2652094583830322 1.0853601432493236 0.46468201476112275 0.9306231615934475 0.0754790652904273 0.16450977680234355 0.5099544077911919 0.0467503302554694 0.10782456372494742 1.4331304842225923e-07 6.843714265989273 -0.6206781284882008 down NLMFLVLR ddPTM_RPMI8226_Bortezomib_8h_R1 2 NLMFLVLR 8 0 O43776;K7EQ35;K7EPK2;K7EMQ6 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 47484900.0 11052600.0 19130300.0 17302000.0 False True 16767602.253294433 15716348.499283869 13882252.116264008 1.0 0.9373044673811953 0.8279211247115835 23.99917306422879 -6.962625816837397 0.39670482590963013 1.0062358957714816 0.7550169357861726 0.9998555095196278 0.0008547233690859584 0.07877624452445076 0.01776144709788024 0.0014083489291586804 0.009176042074959163 1.0898687073493298e-07 6.962625816837397 -0.2512189599853091 NLMFLVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NLMFLVLR 8 0 O43776;K7EQ35;K7EPK2;K7EMQ6 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 53523400.0 9349400.0 13594600.0 30579400.0 False True 12806125.838034848 12993945.620669566 23357175.522511862 1.0 1.0146664014558473 1.823906450547273 23.61033075584671 -6.910829016334831 0.890072566076514 0.9755963429340485 1.9303622021252038 0.9912305834809088 0.036051784542890125 0.10387242285328462 0.13581350966379171 0.029637568856211053 0.08229049514589397 1.227922574572762e-07 6.910829016334831 0.9547658591911553 NLMFLVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NLMFLVLR 8 0 O43776;K7EQ35;K7EPK2;K7EMQ6 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 22937650.0 13047800.0 4874570.0 5015280.0 False True 10849823.81554734 4848309.723883608 6063951.859965302 1.0 0.44685607861541354 0.5588986478541629 23.371168279922777 -10.592850109652613 7.925671547625772 1.0002947998362075 0.5028773632349918 0.9633003414423589 0.045741187350898424 0.00023840622257341 1.224711436997214e-05 0.04431369314225804 0.014762904737148573 2.553582481993055e-11 10.592850109652613 -0.49741743660121573 NLMFLVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NLMFLVLR 8 0 O43776;K7EQ35;K7EPK2;K7EMQ6 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 41146000.0 11052600.0 16721400.0 13372000.0 False True 14307808.579317605 15790839.390708072 10938433.208306583 1.0 1.103651848790753 0.7645079361851708 23.770299386321238 -6.82468971182687 1.3515388234805106 1.0556179902860219 0.7563371107410906 0.8948162871591752 0.04602084931415345 0.1874570285301814 0.6715282494570965 0.026749197545286072 0.061586850767817655 1.4973050459610156e-07 6.82468971182687 -0.2992808795449313 NLNGK(ub)SYSMIVNNLLKPISVEGSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLNGKSYSMIVNNLLKPISVEGSSK 25 2 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 16317200.0 6878600.0 3835700.0 5602900.0 True False 6660242.60815528 5367315.012911257 4135332.406602945 1.0 0.8058737990023263 0.6208981639106279 22.667143299654892 -6.971711740832432 0.21338045536952754 1.0927648692390557 0.3288235273213444 0.9999928317092819 0.0004143697884683857 0.0757510710418817 0.007007328358985909 0.005393352973199824 0.019020841659331166 1.0673043000837434e-07 6.971711740832432 -0.7639413419177112 NLNGTLHELLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLNGTLHELLR 11 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 7767700.0 1259800.0 1229400.0 5278500.0 False True 1651609.9999205552 1045978.3121636674 4732331.4549473375 1.0 0.6333082944605448 2.8652838473822326 20.655441627990935 -6.8647381193099 1.1616488316604126 0.7979590927421695 2.9835235845852583 0.9591390543896978 0.19754568665600802 0.14199541805811255 0.36146222155184204 0.1323624783310851 0.31079643577904936 1.365406231870935e-07 6.8647381193099 2.1855644918430888 up NLNGTLHELLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLNGTLHELLR 11 0 P54886-2;P54886 P54886-2 ALDH18A1 Delta-1-pyrroline-5-carboxylate synthase;Glutamate 5-kinase;Gamma-glutamyl phosphate reductase 0 5837000.0 1259800.0 2928100.0 1649100.0 False True 1725582.1048148887 2798726.860068157 1259616.5442806047 1.0 1.6219030391303169 0.7299661608485037 20.718651689513827 -6.719202647372769 1.761982324692649 1.3786725420287824 0.7313982131849097 0.5088582399685999 0.2617244891091783 0.3568611171726618 2.1647349351073824 0.11795744003190736 0.2964179712489699 1.9089623044335743e-07 6.719202647372769 -0.6472743288438727 NLNLNAALHPDEINIEILNDSHTPGTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLNLNAALHPDEINIEILNDSHTPGTK 27 0 Q9Y5T5-2;Q9Y5T5;Q9Y5T5-3;Q9Y5T5-4 Q9Y5T5-2 USP16 Ubiquitin carboxyl-terminal hydrolase 16 0 30756900.0 8024100.0 15351000.0 7381800.0 False True 12173146.340287348 12611494.112089552 5922783.994442129 1.0 1.0360094062413001 0.48654504175642077 23.537198767584794 -6.8912407350506735 1.014986672086682 1.0286511159870608 0.43811607775522304 0.9816815679362285 0.03396679522612238 0.11814330880230706 0.2160003591315518 0.02545582087387174 0.06375360681108098 1.2845744063415618e-07 6.8912407350506735 -0.5905350382318377 down NLNPK(ub)AACLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLNPKAACLK 10 1 P15884-2;P15884-3;A0A1B0GVR6;P15884-13;P15884-4;P15884-11;E9PH57;A0A1B0GW91;A0A1B0GWD5;H3BTP3;A0A1B0GVB8;A0A0D9SGH7;H0YNP8;K7EKB9;K7EPS2;K7ERZ7;P15923;P15923-3;X6REB3;A0A0A0MRB7;H3BNF4;K7ENH8;A0A0A0MTS0;K7EMM4;P15923-2;F5GY10;Q99081-4;Q99081-2;Q99081;Q99081-3;B4DZP2;P15884-6;H3BPJ7;P15884-16;P15884-8;P15884-9;P15884-15;P15884-7;P15884-5;P15884-10;P15884-14;P15884-12;P15884 P15884-2;F5GY10;P15884-6 TCF4;TCF12;TCF3 Transcription factor 4;Transcription factor E2-alpha;Transcription factor 12 1 5049590.0 839590.0 1791800.0 2418200.0 True False 1100710.6206011246 1524470.424381696 2167987.8610123424 1.0 1.3849874761353225 1.969625640414328 20.070003800172017 -6.965052019645681 0.35716382976140676 0.9479610153662158 2.4265988371946086 0.9999142072429793 0.0036923303528152217 0.0779433744782323 0.014798093731624181 0.007890650482613674 0.05002151472220751 1.0837970893985623e-07 6.965052019645681 1.4786378218283929 NLNPK(ub)AACLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLNPKAACLK 10 1 P15884-2;P15884-3;A0A1B0GVR6;P15884-13;P15884-4;P15884-11;E9PH57;A0A1B0GW91;A0A1B0GWD5;H3BTP3;A0A1B0GVB8;A0A0D9SGH7;H0YNP8;K7EKB9;K7EPS2;K7ERZ7;P15923;P15923-3;X6REB3;A0A0A0MRB7;H3BNF4;K7ENH8;A0A0A0MTS0;K7EMM4;P15923-2;F5GY10;Q99081-4;Q99081-2;Q99081;Q99081-3;B4DZP2;P15884-6;H3BPJ7;P15884-16;P15884-8;P15884-9;P15884-15;P15884-7;P15884-5;P15884-10;P15884-14;P15884-12;P15884 P15884-2;F5GY10;P15884-6 TCF4;TCF12;TCF3 Transcription factor 4;Transcription factor E2-alpha;Transcription factor 12 1 8070900.0 1274600.0 1555600.0 5240700.0 True False 1234138.520680767 2176759.192346833 3868003.452370032 1.0 1.7637883883132537 3.1341728562498727 20.235072902128774 -6.9621116465216195 0.40457515778228187 0.9283663053003749 4.020004866535296 0.9998406755935808 0.011144619695990558 0.07895525414854095 0.018406328726172688 0.017630113567941814 0.11462606272069803 1.0911597898139321e-07 6.9621116465216195 3.0916385612349213 NLNPK(ub)AACLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLNPKAACLK 10 1 P15884-2;P15884-3;A0A1B0GVR6;P15884-13;P15884-4;P15884-11;E9PH57;A0A1B0GW91;A0A1B0GWD5;H3BTP3;A0A1B0GVB8;A0A0D9SGH7;H0YNP8;K7EKB9;K7EPS2;K7ERZ7;P15923;P15923-3;X6REB3;A0A0A0MRB7;H3BNF4;K7ENH8;A0A0A0MTS0;K7EMM4;P15923-2;F5GY10;Q99081-4;Q99081-2;Q99081;Q99081-3;B4DZP2;P15884-6;H3BPJ7;P15884-16;P15884-8;P15884-9;P15884-15;P15884-7;P15884-5;P15884-10;P15884-14;P15884-12;P15884 P15884-2;F5GY10;P15884-6 TCF4;TCF12;TCF3 Transcription factor 4;Transcription factor E2-alpha;Transcription factor 12 1 4446990.0 839590.0 1177500.0 2429900.0 True False 1150009.112066622 1125474.15652821 1856007.665361373 1.0 0.9786654250988313 1.6139069211599877 20.13321386169491 -6.899130990060007 0.9667733637650876 0.9729546535902366 1.6794151122456047 0.9861278122824562 0.034692868184435836 0.11204764098819332 0.1810630576445039 0.026958124199404895 0.06983745560679851 1.2614470049102235e-07 6.899130990060007 0.7064604586553681 NLNPK(ub)AACLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLNPKAACLK 10 1 P15884-2;P15884-3;A0A1B0GVR6;P15884-13;P15884-4;P15884-11;E9PH57;A0A1B0GW91;A0A1B0GWD5;H3BTP3;A0A1B0GVB8;A0A0D9SGH7;H0YNP8;K7EKB9;K7EPS2;K7ERZ7;P15923;P15923-3;X6REB3;A0A0A0MRB7;H3BNF4;K7ENH8;A0A0A0MTS0;K7EMM4;P15923-2;F5GY10;Q99081-4;Q99081-2;Q99081;Q99081-3;B4DZP2;P15884-6;H3BPJ7;P15884-16;P15884-8;P15884-9;P15884-15;P15884-7;P15884-5;P15884-10;P15884-14;P15884-12;P15884 P15884-2;F5GY10;P15884-6 TCF4;TCF12;TCF3 Transcription factor 4;Transcription factor E2-alpha;Transcription factor 12 1 7061400.0 1274600.0 3183100.0 2603700.0 True False 1059886.3743540416 3165952.008504122 3148121.6318513984 1.0 2.9870673735509086 2.9702444601856994 20.01547817756305 -10.067115482549728 4.562789998694448 0.9998909881450646 2.978655916955837 0.9999457874388615 0.00686792592927296 1191276.1240959906 0.32624857982210764 1371.7422434338253 0.0023510736757261885 8.568099819670647e-11 10.067115482549728 1.9787649288107723 NLNVILAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLNVILAK 8 0 P30533;A0A3B3IRQ7 P30533 LRPAP1 Alpha-2-macroglobulin receptor-associated protein 0 9205200.0 1805800.0 2405400.0 4994000.0 False True 2367421.2873920756 2046523.6961757638 4477268.785830638 1.0 0.8644526882793181 1.8912006957421368 21.174885028734035 -6.873661564960338 1.1146160293424605 0.9213592693892083 1.9556499231768636 0.9681994292883774 0.08121715997568202 0.13338895859032587 0.30752159232413434 0.05641680974443062 0.1344786404704653 1.3376374985983185e-07 6.873661564960338 1.0342906537876553 NLNVILAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLNVILAK 8 0 P30533;A0A3B3IRQ7 P30533 LRPAP1 Alpha-2-macroglobulin receptor-associated protein 0 5610600.0 2280900.0 1163500.0 2166200.0 False True 2208494.0780015346 1628091.6175723434 1598807.235392973 1.0 0.7371953738927853 0.7239354867728389 21.074631533171893 NLNVILAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLNVILAK 8 0 P30533;A0A3B3IRQ7 P30533 LRPAP1 Alpha-2-macroglobulin receptor-associated protein 0 13064500.0 2072700.0 7955300.0 3036500.0 False True 3144437.4346672604 6535614.5599574065 2436334.444054769 1.0 2.0784686277750652 0.774807734189368 21.58437049968368 -6.68699100934747 1.8768466279114895 1.6780121335158884 0.7794351286507905 0.3565194219614839 0.45639606728370186 0.42315539178635214 2.88750689859184 0.19469516593058347 0.5089800089713146 2.0559331569423915e-07 6.68699100934747 -0.898577004865098 NLNVILAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLNVILAK 8 0 P30533;A0A3B3IRQ7 P30533 LRPAP1 Alpha-2-macroglobulin receptor-associated protein 0 10270800.0 1805800.0 3551400.0 4913600.0 False True 2473453.059910084 3394487.4050906845 3753108.878768532 1.0 1.3723678286476486 1.5173560151996441 21.238095090256927 -12.063314006020192 0.15625417110953174 2.9141886901489483e-15 1.6830389922309867 0.9995660096232697 0.0045394527455045654 5.5590076429846444 0.10584384680762134 1.9351273572556231 0.13245721703375096 8.643427508769227e-13 12.063314006020192 1.6830389922309839 NLNVILAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLNVILAK 8 0 P30533;A0A3B3IRQ7 P30533 LRPAP1 Alpha-2-macroglobulin receptor-associated protein 0 7374700.0 2072700.0 3236800.0 2065200.0 False True 2683151.00902517 3056669.234624126 1689354.7907414585 1.0 1.1392087975453387 0.629615994425609 21.35549682177613 -6.833895165159945 1.3102274347229355 1.0742132519323742 0.6147619282143759 0.9134611564637892 0.06326455899066379 0.1760649153663078 0.5897005120711162 0.03789283688835329 0.08721599548452033 1.4659016539218105e-07 6.833895165159945 -0.45945132371799824 NLNYLHLDYNFNLKPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLNYLHLDYNFNLKPVK 17 1 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 18841200.0 5626600.0 3002100.0 10212500.0 False True 5447986.662845121 4200854.185744683 7537539.881567138 1.0 0.7710837866755821 1.3835459497308649 22.377291740832977 -6.805482908361618 1.4334811543247314 0.8745613084905209 1.3931842736715632 0.8476940425130223 0.0986115012013129 0.21302478470221234 0.8635479151177357 0.054105061826506824 0.12542897065316347 1.5650099089023893e-07 6.805482908361618 0.5186229651810422 NLNYLHLDYNFNLKPVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLNYLHLDYNFNLKPVK 17 1 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 87000000.0 28749000.0 14760000.0 43491000.0 False True 43614334.83342938 12125962.67959363 34894984.78721753 1.0 0.2780270002031387 0.8000806368018096 25.378299051372544 -9.985553696308882 6.586873371782812 1.000000095856348 0.5390538185036533 0.5096747894830804 0.2131275046718659 2.999385142477217e-07 4.621695338999115e-08 0.2063598621027854 0.068786606351071 1.0338232708396309e-10 9.985553696308882 -0.46094627735269467 NLNYLHLDYNFNLKPVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLNYLHLDYNFNLKPVK 17 1 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 5093900.0 1370100.0 1309900.0 2413900.0 False True 1876662.9955603075 1252024.2867399605 1843786.5358310298 1.0 0.6671545662177608 0.9824814259102168 20.839738168727997 -10.584157358409852 8.966591896898434 1.0000327188650107 0.8248179963396781 0.2915461682082673 0.12873165140678355 8.421582266533147e-05 3.9058360796649125e-06 0.12466710848949153 0.0415479618356876 2.6052094304936143e-11 10.584157358409852 -0.17521472252533254 NLNYLHLDYNFNLKPVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLNYLHLDYNFNLKPVK 17 1 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 19357500.0 5626600.0 4173500.0 9557400.0 False True 4678767.200643684 4151016.527125108 11555808.151575284 1.0 0.8872030492463976 2.469840378034942 22.157697016267253 -6.889784002132559 1.0236815560050303 0.914521883504578 2.60537616394023 0.9807588908615757 0.10000437999159213 0.11931769506262627 0.22288357402929174 0.07445770217857824 0.18547670047804035 1.2888904264349212e-07 6.889784002132559 1.690854280435652 up NLNYLHLDYNFNLKPVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLNYLHLDYNFNLKPVK 17 1 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 62164400.0 28749000.0 18171800.0 15243600.0 False True 37216147.22751224 17160523.355703987 12469421.212544302 1.0 0.46110424195167565 0.33505405963479784 25.149425373464993 -13.999999999999982 0.20410508311710635 4.043592041256184 0.25642464316994334 0.999487564370817 0.006527993963806245 12.615085877973945 0.1432322562813681 15.355178580108834 0.0778732620413514 1.0000000000000409e-14 13.999999999999982 -3.78716739808624 NLPFDFTWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLPFDFTWK 9 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 42984000.0 13311000.0 12672000.0 17001000.0 False True 17450849.903907362 10781386.995069128 15241899.605107475 1.0 0.6178144362272638 0.8734187554781908 24.05679396553434 -10.691843487996403 5.25789210691886 1.006098669260945 0.7456165958527445 0.5690818274604661 0.10435002636937113 0.007597558723709895 0.0004452803816615894 0.10289901707092187 0.03367882619207316 2.033089568232308e-11 10.691843487996403 -0.2604820734082005 NLPFDFTWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLPFDFTWK 9 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 32748800.0 12850000.0 7657800.0 12241000.0 False True 12442083.783734392 10715599.474899445 9034714.87787158 1.0 0.861238331227765 0.7261416202391046 23.568724790572595 -6.971453372287985 0.22073712068828122 1.061723647624772 0.5218383041221564 0.9999916034938551 0.00032392443151834255 0.07583392319808077 0.007319481067986507 0.003721048213932512 0.01367143603683428 1.0679394449280315e-07 6.971453372287985 -0.5398853435026156 NLPFDFTWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLPFDFTWK 9 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 22264500.0 5018000.0 11240000.0 6006500.0 False True 7612672.864939601 9234134.181479163 4819312.642257529 1.0 1.2129950078384757 0.6330644607694916 22.859971652745056 -6.807295512537671 1.4259119330754557 1.1164557849294852 0.6235379251719603 0.8526434659277948 0.09194461175206166 0.2105084628736111 0.8440711654970728 0.05070997865750439 0.11745069026211928 1.5584916775676404e-07 6.807295512537671 -0.4929178597575249 NLPFDFTWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLPFDFTWK 9 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 44176000.0 13311000.0 14236000.0 16629000.0 False True 18232436.41624938 13607006.447843393 12701572.685005272 1.0 0.7463076320242289 0.6966470303269611 24.12000402705723 -13.999999999999998 0.22929856270969973 2.5963037155136277 0.6723399086306562 0.9995088424190611 0.0029442901264825536 13.26947050756058 0.15162358205213308 9.639999267954234 0.02589117191406444 1.0000000000000041e-14 13.999999999999998 -1.9239638068829716 NLPFDFTWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLPFDFTWK 9 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 28404000.0 12850000.0 8682300.0 6871700.0 False True 10685344.351521602 8635526.726598386 8308540.69884903 1.0 0.8081655061840548 0.7775641500655883 23.34913006600687 -13.99999999982352 0.258352415625426 2.3923399082940726 0.766201784986874 0.9995589870584362 0.002067270818232665 14.344914336871277 0.1608415923199247 10.417162408249558 0.013495643757451556 1.0000000004063585e-14 13.99999999982352 -1.6261381233071988 NLPFDFTWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLPFDFTWK 9 0 P52272-2;P52272;A0A087X0X3;M0R2I7;M0QY96 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 19380900.0 5018000.0 6964300.0 7398600.0 False True 6495899.919567859 6576730.582888294 6052130.71604675 1.0 1.012443335691941 0.9316847228227262 22.631097974837505 -6.86757022706325 1.1468057541952423 1.0069446287579313 0.9271671662200601 0.9622008993239032 0.00690236603335534 0.1392094635975574 0.34369121791109225 0.004677428096670163 0.011030167457957691 1.3565311563357125e-07 6.86757022706325 -0.07977746253787121 NLPGLVQEGEPFSEEATLFTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLPGLVQEGEPFSEEATLFTK 21 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 13140900.0 4738500.0 2359500.0 6042900.0 False True 4588078.911223764 3301660.654629952 4460083.20688589 1.0 0.7196172338172167 0.9721025494952236 22.12945877407202 -10.3258916660847 7.5878825993891645 1.0000011826623454 0.8458598918623474 0.33196741255796947 0.10307669849277512 2.062257434483491e-06 1.8325841477156327e-07 0.09980435002598102 0.033267861387046765 4.7218081116081755e-11 10.3258916660847 -0.15414129079999794 NLPLGWDGKPIPYWLYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLPLGWDGKPIPYWLYK 17 1 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 0 15051200.0 6137900.0 3624800.0 5288500.0 False True 5943055.724216596 5072201.543082279 3903283.1984007657 1.0 0.8534669332502158 0.6567805148613662 22.502773477560975 -6.967038185861607 0.32116210131422906 1.026571475251638 0.4773211716627483 0.9999491967373106 0.0010022475523576281 0.07727603450478601 0.012456774555083292 0.0029674704150421502 0.017283286214311393 1.0788518587197366e-07 6.967038185861607 -0.5492503035888896 NLPLGWDGKPIPYWLYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLPLGWDGKPIPYWLYK 17 1 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 0 12990000.0 6137900.0 3051000.0 3801100.0 False True 5103935.805074272 3034563.657423916 4595892.435699333 1.0 0.5945536490500114 0.900460470355084 22.28317875299525 -10.325122013697618 5.826250228066472 1.000029528391291 0.7475070597025482 0.4759903668880936 0.12488593683903328 4.790675482725073e-05 5.549193803707743e-06 0.12093441142402848 0.04030676279609017 4.730183472434209e-11 10.325122013697618 -0.25252246868874284 NLPLGWDGKPIPYWLYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLPLGWDGKPIPYWLYK 17 1 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 0 13349100.0 3482500.0 5004500.0 4862100.0 False True 4508164.900337798 4725995.1756909415 3977247.6893589203 1.0 1.0483190566824256 0.8822320783032813 22.104108856916948 -6.82887342927308 1.3331149097847343 1.025838626066387 0.8778703867799481 0.9035672990008554 0.021660721066049955 0.182207585019455 0.6337295247052668 0.012759498646347067 0.029362079385630565 1.4829502129890841e-07 6.82887342927308 -0.14796823928643887 NLPLPPPPPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLPLPPPPPPR 11 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 6879300.0 2108300.0 1038000.0 3733000.0 False True 2041373.1705250752 1452478.8130984914 2755215.312400503 1.0 0.7115204775248857 1.3496872361126486 20.961108505763796 -6.783797742133345 1.5208622461991341 0.8374573427027167 1.3553757877142854 0.7806388296126039 0.1222090202590819 0.24473298555898326 1.1182584256467898 0.06327141460733032 0.14884050377332428 1.6451377117047092e-07 6.783797742133345 0.5179184450115687 NLPYK(ub)ITAEEMYDIFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLPYKITAEEMYDIFGK 17 1 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 1 16767400.0 2321600.0 5808200.0 8637600.0 True False 3522036.9316946524 4771681.33032627 6930374.5740054315 1.0 1.3548072955698232 1.9677177464095568 21.747978606515264 -6.96280541989458 0.39390584158050096 0.9639572915143316 2.3807287153023347 0.9998605165357307 0.0047208805573721166 0.07871377214074653 0.01753674999513621 0.007898681235453607 0.05147354651140518 1.0894180838888483e-07 6.96280541989458 1.4167714237880031 NLPYK(ub)ITAEEMYDIFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLPYKITAEEMYDIFGK 17 1 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 1 5576850.0 3091000.0 2022100.0 463750.0 True False 2570303.4545177617 2011206.5459445778 560717.9808622673 1.0 0.7824782487879116 0.21815244417024246 21.29350726589649 -7.014576455984464 0.5265035661797991 1.008495663166011 1.284921858973259e-15 0.9994791398282821 0.007519706743589827 0.07488585160948982 0.030086821477110497 0.008622960753081145 0.042308115415242424 9.669934759344184e-08 7.014576455984464 -1.0084956631660096 down NLPYK(ub)ITAEEMYDIFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLPYKITAEEMYDIFGK 17 1 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 1 20358900.0 2321600.0 6276300.0 11761000.0 True False 3005356.9655776666 5927018.387688889 9620618.67805069 1.0 1.9721512138407968 3.2011567305454807 21.519104928607714 -6.967943078924513 0.30331984807639367 0.795086455039275 4.41691424922905 0.9999616011284772 0.005581073210569502 0.076975933322816 0.011406429875603218 0.020061330116698244 0.10984259087740558 1.0766063104566223e-07 6.967943078924513 3.621827794189775 NLPYK(ub)VTQDELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLPYKVTQDELK 12 1 P19338 P19338 NCL Nucleolin 1 16367800.0 3632400.0 7111200.0 5624200.0 True False 4762111.576211641 6050236.679240495 5042261.735135898 1.0 1.2704945237871945 1.058828978372473 22.183169992654268 -10.308743009511145 4.9854944927876 0.9999410702213253 1.1646617510798936 0.44656829667617215 0.08641209706586893 5.662056301032121e-05 7.850747719529426e-06 0.0836980587642517 0.027889384403884408 4.911984531560287e-11 10.308743009511145 0.16472068085856828 NLPYK(ub)VTQDELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLPYKVTQDELK 12 1 P19338 P19338 NCL Nucleolin 1 65294700.0 10305000.0 19150700.0 35839000.0 True False 15633438.39641342 15733107.959897969 28755405.9412083 1.0 1.0063754089764039 1.8393526242957075 23.8981317817625 -6.908577680844272 0.9053658578051803 0.9730346226000346 1.943789129547963 0.9903735998290735 0.038674713480284915 0.10536630729222556 0.1439248795202048 0.031442445484518425 0.08596343730359443 1.2343045193818974e-07 6.908577680844272 0.9707545069479284 NLPYK(ub)VTQDELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLPYKVTQDELK 12 1 P19338 P19338 NCL Nucleolin 1 20091400.0 3632400.0 3815300.0 12643700.0 True False 4975396.441919036 3646727.43049009 9657518.465175355 1.0 0.7329521321688948 1.9410550652422784 22.24638005417716 -6.848750920061557 1.241228885592492 0.8576364041129828 1.988163091742135 0.9384440665916569 0.1285580238657284 0.15884420363775517 0.47157933698836624 0.08107390689182645 0.18745226771801088 1.4166060098786651e-07 6.848750920061557 1.130526687629152 NLPYK(ub)VTQDELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLPYKVTQDELK 12 1 P19338 P19338 NCL Nucleolin 1 23660900.0 6189900.0 8579500.0 8891500.0 True False 5147176.10906486 8533280.53060259 10750671.540349 1.0 1.6578567256663999 2.0886543053025988 22.295349714085056 -8.42016301768837 0.12612434266805175 6.818089138527534e-18 3.1176876533943974 0.9999518618109069 0.0031058793513099228 0.12219525242621837 0.029783660890968115 0.35356451406032413 0.32713456067018587 3.800467144110549e-09 8.42016301768837 3.1176876533943974 NLPYK(ub)VTQDELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLPYKVTQDELK 12 1 P19338 P19338 NCL Nucleolin 1 56279000.0 10305000.0 24855000.0 21119000.0 True False 13340025.641918443 23471797.400699064 17275558.699239235 1.0 1.7595016704423336 1.2950169034873624 23.66925810385495 -10.19104185980915 4.445778202752756 0.9998664719780153 1.5272592869763735 0.6320937126310073 0.1896251120949724 133185277.90467235 45.24192642958942 182051.9503647177 0.06491371959660078 6.441071797550108e-11 10.19104185980915 0.5273928149983582 NLPYVYIPSK(ub)TDLGAAAGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLPYVYIPSKTDLGAAAGSK 20 1 Q9NX24 Q9NX24 NHP2 H/ACA ribonucleoprotein complex subunit 2 1 11006900.0 2870000.0 4128900.0 4008000.0 True False 3931116.558833728 3946471.5455535725 3061392.9473510836 1.0 1.0039060115593215 0.7787591391742728 21.906507710078902 -6.90295276453279 0.9424053318021954 1.0086175893380303 0.7536557343804015 0.9879791271549976 0.01153702464356918 0.10926453312843777 0.1654125280460887 0.00912806002779855 0.02412175792951976 1.2503950203893856e-07 6.90295276453279 -0.2549618549576288 NLQEEIDALESR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLQEEIDALESR 12 0 E9PQY2;Q9NQP4 E9PQY2 PFDN4 Prefoldin subunit 4 0 6607000.0 2281300.0 2265700.0 2060000.0 False True 2208881.380220484 3170405.8254694156 1520424.2013246822 1.0 1.4352992667958273 0.6883231553035764 21.074884515512796 -6.748766574510679 1.6547608582022675 1.2563424341109644 0.6870082186665085 0.6435181406547366 0.18290404664849774 0.30219360074260837 1.6277374860257614 0.08733650098028872 0.21227554282592645 1.7833370215446426e-07 6.748766574510679 -0.5693342154444558 NLQEQTVQLQSELSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLQEQTVQLQSELSR 15 0 P12270 P12270 TPR Nucleoprotein TPR 0 4246800.0 0.0 2285200.0 1961600.0 False True 0.0 1944257.0676398333 1758632.448995872 0.0 NLQEQTVQLQSELSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLQEQTVQLQSELSR 15 0 P12270 P12270 TPR Nucleoprotein TPR 0 6456700.0 2633300.0 0.0 3823400.0 False True 2549707.3328955453 0.0 2821936.84045864 1.0 0.0 1.1067689236528728 21.281900226756537 -10.67253469214052 4.28730306277116 1.0176193821970547 0.553384461831982 0.1783858462689465 0.45183652102047533 0.0767676088595951 0.005863525601562502 0.4413539546356404 0.14582961009329135 2.1255205484412222e-11 10.67253469214052 -0.46423492036507275 NLQEQTVQLQSELSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLQEQTVQLQSELSR 15 0 P12270 P12270 TPR Nucleoprotein TPR 0 6085800.0 0.0 2619000.0 3466800.0 False True 0.0 2503283.920125163 2648013.24098721 0.0 NLQEVLGEEKLK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLQEVLGEEKLK 12 1 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 1 26017000.0 3204000.0 3982000.0 18831000.0 True False 4147641.1602820707 3760398.1995406784 15403951.222376706 1.0 0.9066353751984039 3.7139064415420937 21.983859651837044 -6.899204631922275 0.966260761202082 0.8807232015495935 4.003885243032802 0.9861670734578579 0.15312238934413475 0.11199384254723435 0.1807306448249268 0.11902590365126058 0.3084749129543522 1.261233123696125e-07 6.899204631922275 3.1231620414832086 up NLQK(ub)LVLSHMDVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLQKLVLSHMDVSR 14 1 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4;A0A0G2JN56;H0Y7S4;Q5TYX0;Q5VWM5;A6NGN4;O60813 A3QJZ7 LOC101929983;PRAMEF25;PRAMEF6;PRAMEF26;PRAMEF5;PRAMEF9;PRAMEF11 PRAME family member 6;Putative PRAME family member 26;PRAME family member 5;PRAME family member 9/15;PRAME family member 25;PRAME family member 11 1 14332600.0 2927100.0 4813000.0 6592500.0 True False 3837456.4460767205 4094919.1609270554 5910371.339725373 1.0 1.06709202266349 1.5401793929851446 21.871718945765114 -6.932521976167527 0.725787881641363 0.9934361565745121 1.6438500678384647 0.9970112154239055 0.013142326916972017 0.09134905269993314 0.07141760680261751 0.012158277270985606 0.04222821101790399 1.1680946204467927e-07 6.932521976167527 0.6504139112639525 NLQK(ub)LVLSHMDVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLQKLVLSHMDVSR 14 1 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4;A0A0G2JN56;H0Y7S4;Q5TYX0;Q5VWM5;A6NGN4;O60813 A3QJZ7 LOC101929983;PRAMEF25;PRAMEF6;PRAMEF26;PRAMEF5;PRAMEF9;PRAMEF11 PRAME family member 6;Putative PRAME family member 26;PRAME family member 5;PRAME family member 9/15;PRAME family member 25;PRAME family member 11 1 20911500.0 3035100.0 3840400.0 14036000.0 True False 2938752.4118297445 5373891.747421423 10359550.529025853 1.0 1.828630314615547 3.5251525400112644 21.486772387220636 -6.959584235786245 0.44125373727895073 0.9401264609872068 4.479939271413801 0.9997544686391889 0.016468416966853996 0.0798499685206144 0.021682566271418534 0.022402947753329756 0.14053456374675685 1.0975283929483822e-07 6.959584235786245 3.539812810426594 NLQK(ub)LVLSHMDVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLQKLVLSHMDVSR 14 1 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4;A0A0G2JN56;H0Y7S4;Q5TYX0;Q5VWM5;A6NGN4;O60813 A3QJZ7 LOC101929983;PRAMEF25;PRAMEF6;PRAMEF26;PRAMEF5;PRAMEF9;PRAMEF11 PRAME family member 6;Putative PRAME family member 26;PRAME family member 5;PRAME family member 9/15;PRAME family member 25;PRAME family member 11 1 97243000.0 10772000.0 29235000.0 57236000.0 True False 16341911.538686596 24017785.83590244 45923279.512570046 1.0 1.4697048003866968 2.8101534758559166 23.962073411837554 -6.952568807003465 0.5299011814022806 0.9788440582255222 3.3618540905957337 0.9993877119326576 0.01897806405244813 0.08247050906031715 0.03181925909316035 0.021175936739471164 0.11084635451299815 1.1154014198643116e-07 6.952568807003465 2.3830100323702115 NLQK(ub)LVLSHMDVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLQKLVLSHMDVSR 14 1 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4;A0A0G2JN56;H0Y7S4;Q5TYX0;Q5VWM5;A6NGN4;O60813 A3QJZ7 LOC101929983;PRAMEF25;PRAMEF6;PRAMEF26;PRAMEF5;PRAMEF9;PRAMEF11 PRAME family member 6;Putative PRAME family member 26;PRAME family member 5;PRAME family member 9/15;PRAME family member 25;PRAME family member 11 1 19483100.0 2927100.0 3236000.0 13320000.0 True False 4009327.9719032035 3093022.8199790125 10174090.33401108 1.0 0.7714566734511303 2.5376049066850226 21.934929007288005 -6.8743663056695095 1.1106789771239942 0.866599970804753 2.650026182401721 0.9688528241949466 0.13841270082306795 0.1327403029747074 0.3034056015958353 0.09643154733868514 0.23021325496782388 1.3354686403912777e-07 6.8743663056695095 1.783426211596968 up NLQK(ub)LVLSHMDVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLQKLVLSHMDVSR 14 1 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4;A0A0G2JN56;H0Y7S4;Q5TYX0;Q5VWM5;A6NGN4;O60813 A3QJZ7 LOC101929983;PRAMEF25;PRAMEF6;PRAMEF26;PRAMEF5;PRAMEF9;PRAMEF11 PRAME family member 6;Putative PRAME family member 26;PRAME family member 5;PRAME family member 9/15;PRAME family member 25;PRAME family member 11 1 24358400.0 3035100.0 8620300.0 12703000.0 True False 2523820.127727874 8573860.732904429 15359138.567964148 1.0 3.397175828304072 6.085670844455765 21.267177662654912 -6.96963949014933 0.2666595398693008 0.3040076554506711 9.259304158765993 0.999979431542699 0.009421298794426354 0.07641987954469166 0.009448092169433703 0.05379969172287145 0.2512135105428173 1.0724091476305158e-07 6.96963949014933 8.95529650331532 NLQK(ub)LVLSHMDVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLQKLVLSHMDVSR 14 1 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4;A0A0G2JN56;H0Y7S4;Q5TYX0;Q5VWM5;A6NGN4;O60813 A3QJZ7 LOC101929983;PRAMEF25;PRAMEF6;PRAMEF26;PRAMEF5;PRAMEF9;PRAMEF11 PRAME family member 6;Putative PRAME family member 26;PRAME family member 5;PRAME family member 9/15;PRAME family member 25;PRAME family member 11 1 54339000.0 10772000.0 15420000.0 28147000.0 True False 13944566.347864674 14561863.44473061 23024534.812608868 1.0 1.0442679307098326 1.651147424612068 23.733199733930004 -6.9215624687376955 0.8130535676291964 0.9873488828159769 1.7526183156364334 0.994604092823313 0.02182182338380222 0.09726105098138824 0.10091385793293611 0.01895900971055046 0.05766804976959546 1.197946798627381e-07 6.9215624687376955 0.7652694328204566 NLQLLMDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLQLLMDR 8 0 A0A087WZK9;B3KS98;O15372;E5RJT0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 0 6565200.0 2305800.0 2008000.0 2251400.0 False True 3022926.129398964 1708414.2271226954 2018446.7249537625 1.0 0.5651524893406418 0.6677128843221458 21.527514293889556 -9.826964768194957 6.314644979186973 1.0000000150155262 0.6164326868312767 0.9491076022846863 0.04187010592095269 8.852234923846e-09 1.626334279790319e-09 0.040540556941947435 0.013513518577915572 1.4894819058811636e-10 9.826964768194957 -0.38356732818424943 NLQNLLILTAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLQNLLILTAIK 12 0 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 21119800.0 3962100.0 11058000.0 6099700.0 False True 5194351.469030984 9408189.50374639 5468561.556453971 1.0 1.8112346767134544 1.0527900526288687 22.308512204725318 -10.260109948002885 4.269043982055573 0.9997033726306206 1.4320123646820326 0.30196690565108975 0.3096337212391946 0.0008841942659367943 0.00015324360253840156 0.30000695533285526 0.09993385380896588 5.494017671534713e-11 10.260109948002885 0.43230899205141204 NLQNLLILTAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLQNLLILTAIK 12 0 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 20733900.0 10409000.0 4499100.0 5825800.0 False True 10078571.992598522 6295614.092496551 4299848.209746281 1.0 0.6246533831499054 0.426632682973738 23.264787905714012 -11.29405635138794 0.11010921940330692 2.076878850930469 1.4830570832007517e-16 0.9998427037112895 0.0029821599444300796 3.901455260774569 0.07001727772329146 1.3266693592373193 0.29125624383519033 5.080935111859425e-12 11.29405635138794 -2.076878850930469 NLQNLLILTAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLQNLLILTAIK 12 0 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 28052500.0 3962100.0 9112400.0 14978000.0 False True 5426995.441726522 8709784.037322855 11440504.881592937 1.0 1.6048998254828017 2.108073427449444 22.37172226624821 -6.973242129258637 0.16309174649081676 0.5118202251783025 3.214541440304255 0.999997891358793 0.0006577891737720201 0.07526398915810047 0.005050412533486721 0.022614804297325458 0.05970688159360661 1.0635498991348397e-07 6.973242129258637 2.7027212151259525 NLQNLLILTAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLQNLLILTAIK 12 0 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 20080600.0 10409000.0 3927000.0 5744600.0 False True 8655544.696886236 3905844.4715515305 6945769.29997063 1.0 0.45125345756190566 0.8024647255844356 23.04519318114829 -10.126871672905416 5.3247493053642705 1.0000083691896886 0.6268590915729756 0.6008045236953052 0.14338139976256414 1.4245815346542234e-05 2.3358118044746766e-06 0.13883155530634594 0.04627614778625585 7.46669354705802e-11 10.126871672905416 -0.373149277616713 NLQPASEYTVSLVAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLQPASEYTVSLVAIK 16 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 36186600.0 8721600.0 15359000.0 12106000.0 False True 11434102.06009455 13067497.068913102 10853387.248951873 1.0 1.1428529324151446 0.949212031859555 23.44683973706087 -6.709023217761666 1.79840081361837 1.0879075651496142 0.94967385468751 0.46062202982580935 0.06020639756046163 0.3770267821091828 2.376334248530227 0.02664581002528114 0.06778042641918289 1.9542349778768566e-07 6.709023217761666 -0.1382337104621042 NLQPASEYTVSLVAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLQPASEYTVSLVAIK 16 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 37140000.0 14365000.0 10091000.0 12684000.0 False True 13908990.938003471 14120388.923869818 9361679.888156438 1.0 1.0151986572432616 0.6730667903864661 23.72951442402388 -6.896506023021656 0.9831125873645962 1.0156201004184282 0.6395996368763556 0.9847457491506222 0.01949231560773317 0.11402232408927505 0.19228796839073398 0.014963007084404028 0.0382908488172469 1.2690945438602324e-07 6.896506023021656 -0.37602046354207264 NLQPASEYTVSLVAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLQPASEYTVSLVAIK 16 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 37233600.0 8721600.0 11674000.0 16838000.0 False True 11946211.212377785 11158204.079244448 12861211.18949538 1.0 0.9340370667214671 1.0765933199112987 23.51004979858376 -6.78089824471465 1.5324278371671445 0.9626929497199562 1.0777531274085626 0.770512982958166 0.0279056293212678 0.24919495262612823 1.1559343295470794 0.014341901659682693 0.03381473964788541 1.656157956159997e-07 6.78089824471465 0.11506017768860632 NLQPASEYTVSLVAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLQPASEYTVSLVAIK 16 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 24234200.0 14365000.0 6380700.0 3488500.0 False True 11945133.97740139 6346325.902630215 4217929.220998428 1.0 0.5312896376580306 0.35310857366507487 23.509919699458155 -13.999999999999998 0.13407932588210067 3.230079864164474 0.11603980106743711 0.9996275559567783 0.005265214494674175 11.932538721875655 0.11425323889224047 6.989271745976871 0.2112053369532519 1.0000000000000041e-14 13.999999999999998 -3.114040063097037 NLQQELETQNQK(ub)LQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLQQELETQNQKLQR 15 1 H7BYN4;Q02241-3;Q02241-2;Q02241;A0A2U3TZL8 H7BYN4 KIF23 Kinesin-like protein;Kinesin-like protein KIF23 1 16861300.0 4734200.0 5551700.0 6575400.0 True False 6206582.046058019 4723408.0003571035 5895040.683690583 1.0 0.7610320729357115 0.9498046815371909 22.56536756680094 -9.908697018208567 5.511768810130749 1.0000001396701013 0.8554183773909517 0.4388782578454855 0.07706609474973919 1.3230224107017892e-07 2.6225411006614788e-08 0.07461899765385221 0.02487297512665683 1.2339653983053388e-10 9.908697018208567 -0.14458176227914954 NLQQELETQNQK(ub)LQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLQQELETQNQKLQR 15 1 H7BYN4;Q02241-3;Q02241-2;Q02241;A0A2U3TZL8 H7BYN4 KIF23 Kinesin-like protein;Kinesin-like protein KIF23 1 10350900.0 5856700.0 4494200.0 0.0 True False 5670782.264295492 6288757.496943393 0.0 1.0 1.1089753060241458 0.0 22.43511633288236 -6.955584041555374 1.194152140241376 1.0628436731969721 1.295878979920999e-19 0.9736364593655266 0.08103442165292138 0.10539062755175889 0.2982575232422647 0.05652247473819708 0.10692821387361813 1.107684193527194e-07 6.955584041555374 -1.0628436731969721 down NLQQELETQNQK(ub)LQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLQQELETQNQKLQR 15 1 H7BYN4;Q02241-3;Q02241-2;Q02241;A0A2U3TZL8 H7BYN4 KIF23 Kinesin-like protein;Kinesin-like protein KIF23 1 16249700.0 5856700.0 5887000.0 4506000.0 True False 4870105.545802058 5855285.562521994 5448183.766609975 1.0 1.2022913071297077 1.1186993208609637 22.215521608316635 -10.361410442806484 5.095632355688576 0.9999105779242043 1.160495313995353 0.8309417295692352 0.03412628549075417 3.4687652953027816e-05 4.347137953339719e-06 0.03306100770076843 0.011014211281125525 4.3510047478003676e-11 10.361410442806484 0.16058473607114876 NLQSEVEGVK(ub)NIMTQNVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLQSEVEGVKNIMTQNVER 19 1 Q9BV40;B8ZZT4 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 18874200.0 7737100.0 6824900.0 4312200.0 True False 7491489.995574411 9550118.161383329 3182705.4567729603 1.0 1.2747955569619729 0.42484278276459553 22.836821256692073 -6.819670016286088 1.373248706488431 1.1481662588660924 0.4064115465519983 0.8836245975871867 0.12081085083530384 0.1939176923917548 0.7186468174841211 0.0691330078873137 0.15935873857827856 1.51471171286999e-07 6.819670016286088 -0.7417547123140941 down NLQSEVEGVK(ub)NIMTQNVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLQSEVEGVKNIMTQNVER 19 1 Q9BV40;B8ZZT4 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 19294200.0 0.0 8672200.0 10622000.0 True False 0.0 7124578.153792129 8522557.044212015 0.0 NLQSEVEGVK(ub)NIMTQNVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLQSEVEGVKNIMTQNVER 19 1 Q9BV40;B8ZZT4 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 19707600.0 7737100.0 8450300.0 3520200.0 True False 6433741.4616465075 8404776.556646785 4256257.544434184 1.0 1.306359076868447 0.6615524683121061 22.61722653212635 -6.777506656197036 1.5455554358764334 1.174031353888165 0.6568362800003147 0.7584670431525271 0.12942591219786104 0.25447413553391324 1.2004800006435572 0.06596735255346108 0.15598474913638224 1.6691422249733512e-07 6.777506656197036 -0.5171950738878504 NLQSEVEGVK(ub)NIMTQNVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLQSEVEGVKNIMTQNVER 19 1 Q9BV40;B8ZZT4 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 8719400.0 0.0 0.0 8719400.0 True False 0.0 0.0 7132558.668599197 0.0 NLQVK(ub)CAQIEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLQVKCAQIEAK 12 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 8462000.0 3708000.0 2508900.0 2245100.0 True False 4861223.908323078 2134581.8996156026 2012798.5885198987 1.0 0.43910380181437586 0.4140518162666223 22.21288815561849 -13.656041949820386 0.4466681928125072 9.999999999918305 0.41400554010917756 0.9998900271697998 0.0028367474178354274 25.28402089365358 0.2265853727005872 221.68621524790746 0.005700869278634158 2.207791465449357e-14 13.656041949820386 -9.585994459809127 NLQVK(ub)CAQIEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLQVKCAQIEAK 12 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 7870300.0 3489000.0 3156500.0 1224800.0 True False 3378243.6047820468 4416906.910930041 903988.136787608 1.0 1.3074566039813478 0.2675911634992736 21.687841933798367 -6.827507455870595 1.339015844950723 1.164588428689157 0.24100779556974014 0.9007970239063761 0.1373812690750753 0.18390629022045574 0.6457526954415538 0.08057663190989449 0.18545857086893988 1.4876218347011188e-07 6.827507455870595 -0.9235806331194168 down NLQVK(ub)CAQIEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLQVKCAQIEAK 12 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 21892100.0 7193700.0 4120400.0 10578000.0 True False 10913368.829915497 3385082.427167859 8487253.663497897 1.0 0.31017758860020767 0.7776932857096166 23.37959317778807 -10.523229524107126 6.728321416893103 1.00028259295018 0.5439354381180705 0.559241671613651 0.1908624841099374 0.0008095640099112689 5.7365727783525764e-05 0.18491275983457373 0.061600601864463755 2.9975778840084115e-11 10.523229524107126 -0.4563471548321094 NLQVK(ub)CAQIEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLQVKCAQIEAK 12 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 10099000.0 3708000.0 3286900.0 3104100.0 True False 5078947.804932214 3141673.8896752237 2370975.510946231 1.0 0.6185678629389171 0.46682415374376446 22.27609821714138 -13.999999999999929 0.12719595810845344 2.8125691855103434 0.24655117673091895 0.9996584887022596 0.004145059485122321 11.941952902315748 0.1106214384583022 5.4260427613327105 0.19571479426028707 1.0000000000001636e-14 13.999999999999929 -2.5660180087794244 NLQVK(ub)CAQIEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLQVKCAQIEAK 12 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 9239500.0 3489000.0 1651000.0 4099500.0 True False 2901258.088907305 1642105.7353021565 4956686.49605361 1.0 0.5659978137004072 1.7084610690117668 21.468247209232644 -6.803767466240539 1.4404955905993615 0.7616705310502312 1.7257343704891077 0.8429351916557253 0.18661380102617517 0.21543099550729788 0.8821046312624375 0.10189699479342446 0.236450765476467 1.5712038468945275e-07 6.803767466240539 0.9640638394388765 NLQVK(ub)CAQIEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLQVKCAQIEAK 12 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 25361700.0 7193700.0 11464700.0 6703300.0 True False 9312386.459026558 10826679.366718754 5483368.181666276 1.0 1.1626106169836177 0.5888252389215668 23.15071949988052 -6.831013220600242 1.3235516369473377 1.0868260838766273 0.5730820787531706 0.9078535734001181 0.07329741420315164 0.17956524073914557 0.614867645697113 0.04347909269836861 0.10004638948440923 1.4756616111550452e-07 6.831013220600242 -0.5137440051234566 NLQYYDISAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLQYYDISAK 10 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 70975400.0 8884400.0 33959000.0 28132000.0 False True 11647534.436651997 28892449.571145218 25221170.50119893 1.0 2.480563567189603 2.1653656092085853 23.47352126008084 -10.510554331436415 5.075655405194841 0.9956619890664222 2.322964588199117 0.9591656873419426 0.12867902750354884 0.006321047274735709 0.0006095384793162005 0.12467809708628692 0.04153097754393692 3.0863535102022656e-11 10.510554331436415 1.327302599132695 NLQYYDISAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLQYYDISAK 10 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 57201900.0 16275000.0 8498900.0 32428000.0 False True 15758359.033484612 11892555.091178006 23934133.980852846 1.0 0.7546823286553987 1.5188214667527056 23.909613974544353 -6.820314077017157 1.3704485018645265 0.867811520515286 1.5356231855014308 0.8851002476326532 0.10797835852132498 0.19308726401836326 0.712477531691898 0.06191265877235701 0.14269153120718225 1.5124670532057912e-07 6.820314077017157 0.6678116649861449 NLQYYDISAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLQYYDISAK 10 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 114913400.0 8884400.0 27541000.0 78488000.0 False True 12169202.771882365 26324147.55409206 59950750.91110069 1.0 2.1631776581877245 4.926432078987156 23.53673132160373 -6.956545801920422 0.48165243848961026 0.9346946638396151 6.270444966135394 0.9996198666000288 0.0321062771855855 0.08095888356200531 0.025871721550394397 0.039092637858022104 0.2279329632494363 1.1052339021530073e-07 6.956545801920422 5.3357503022957795 NLQYYDISAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLQYYDISAK 10 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 28665600.0 16275000.0 7800500.0 4590100.0 False True 13533383.60474818 7758477.158221969 5549868.687775507 1.0 0.5732843599807451 0.4100872959684922 23.69001924997863 -13.999999999999998 0.13317278806802318 3.029506808809653 0.19049002084019825 0.9996314966523838 0.004774371401193551 11.93314199798045 0.11378608232042825 6.322373745063155 0.19555512109687473 1.0000000000000041e-14 13.999999999999998 -2.839016787969455 NLQYYDISAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLQYYDISAK 10 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 30450700.0 9156700.0 11294000.0 10000000.0 False True 11853528.655541455 10665478.971776107 8180102.608664808 1.0 0.8997724881518769 0.6900985222523301 23.49881326055396 -6.959155874832069 0.4471710705877878 1.0069605054773025 0.574637508305699 0.9997375986501212 0.0020915811805706113 0.08000404226362083 0.022255909223987912 0.0027909901153162545 0.017351062810981744 1.098611460459072e-07 6.959155874832069 -0.4323229971716035 NLREDGEK(ub)AAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLREDGEKAAR 11 2 P04899-4;P04899;P63096;A0A3B3IUA8;A0A3B3IU77;A0A3B3ITG4;F8WE78;A0A3B3ITX3;A0A3B3IS42;A0A3B3IRK0 P04899-4 GNAI2;GNAI1 Guanine nucleotide-binding protein G(i) subunit alpha-2;Guanine nucleotide-binding protein G(i) subunit alpha-1 1 2711250.0 692840.0 926410.0 1092000.0 True False 1051088.9333887524 761084.8974256337 876165.7213593973 1.0 0.724091818731138 0.8335790564691841 20.00345331125113 -10.112469309282558 4.814376538681967 1.000011798005806 0.7788354375983896 0.8447337590231139 0.0446979776402694 5.660579386274328e-06 1.0434739322818743e-06 0.04328093883578531 0.014426210249958667 7.718460584661367e-11 10.112469309282558 -0.2211763604074165 NLREDGEK(ub)AAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLREDGEKAAR 11 2 P04899-4;P04899;P63096;A0A3B3IUA8;A0A3B3IU77;A0A3B3ITG4;F8WE78;A0A3B3ITX3;A0A3B3IS42;A0A3B3IRK0 P04899-4 GNAI2;GNAI1 Guanine nucleotide-binding protein G(i) subunit alpha-2;Guanine nucleotide-binding protein G(i) subunit alpha-1 1 3688580.0 692840.0 2024130.0 971610.0 True False 896895.0379181748 1911485.386146728 794786.9495604828 1.0 2.131225288728954 0.8861538039114366 19.774579633343578 -6.667547303218375 1.9459087223634581 1.72359260650544 0.8912297728308212 0.2681612857654283 0.4807975350665498 0.4668599459868936 3.4056930880170855 0.19907338701179403 0.5336119360785642 2.1500704815855e-07 6.667547303218375 -0.8323628336746189 NLSFFLTPPCAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLSFFLTPPCAR 12 0 J3KPM9;A0A669KBI6;A0A669KB68;A0A669KB56;A0A669KBA4;A0A669KB53;P42224-2;P42224;A0A669KB52;A0A669KB75 J3KPM9 STAT1 Signal transducer and activator of transcription;Signal transducer and activator of transcription 1-alpha/beta 0 4361000.0 1330900.0 1455900.0 1574200.0 False True 1744822.788453932 1238685.3950537515 1411316.8847926708 1.0 0.709920459115127 0.808859727263892 20.734649087019086 -10.817595778270507 10.228531828272363 1.0032778276721934 0.7593900931895096 0.8874568893306752 0.04039178708147903 0.0030422436079238606 5.425186777868571e-05 0.03940742647635932 0.013036393224177005 1.5219634456731105e-11 10.817595778270507 -0.24388773448268386 NLSFFLTPPCAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLSFFLTPPCAR 12 0 J3KPM9;A0A669KBI6;A0A669KB68;A0A669KB56;A0A669KBA4;A0A669KB53;P42224-2;P42224;A0A669KB52;A0A669KB75 J3KPM9 STAT1 Signal transducer and activator of transcription;Signal transducer and activator of transcription 1-alpha/beta 0 3510810.0 1330900.0 851310.0 1328600.0 False True 1822969.6962201395 813696.3092942943 1014812.0433759104 1.0 0.44635756204914634 0.5566806982475275 20.797859148541978 -10.013696228941424 6.077150308796408 1.0000005055128864 0.5015191301485108 0.9645652723984108 0.0450392317517188 3.085375635035805e-07 5.004301666746151e-08 0.04360909281096002 0.01453634954168133 9.689553635592042e-11 10.013696228941424 -0.49848137536437565 NLSSDK(ub)YGDTSYHDEEEDEYEAEDDEEEEDEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLSSDKYGDTSYHDEEEDEYEAEDDEEEEDEGR 33 1 Q9Y3S2 Q9Y3S2 ZNF330 Zinc finger protein 330 1 13456200.0 3146300.0 3959300.0 6350600.0 True False 3046422.428697551 5540269.13747674 4687187.346083757 1.0 1.8186148727395608 1.5385874598118974 21.538684574685746 -10.046921260012976 4.31205246143091 0.9999486349927084 1.6786011663843157 0.886750890864506 0.11432071302655254 10180510.633932766 3388602.795391468 4935.937583200707 0.039135020890177896 8.975915180462003e-11 10.046921260012976 0.6786525313916073 NLTALGLNLVASGGTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLTALGLNLVASGGTAK 17 0 P31939-2;P31939;F8WEF0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 19859000.0 6198800.0 7157400.0 6502800.0 False True 8126686.8292645905 6089543.819326681 5829952.635262214 1.0 0.7493267486816325 0.7173836961784074 22.95423586883045 -13.999999999999998 0.2904751664230407 3.165838623496875 0.7087207054524768 0.9996285240394073 0.0024356546408482254 15.994118508820609 0.17092489691633497 20.705842458357644 0.012038283646385971 1.0000000000000041e-14 13.999999999999998 -2.457117918044398 NLTALGLNLVASGGTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLTALGLNLVASGGTAK 17 0 P31939-2;P31939;F8WEF0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 45125500.0 18285000.0 8898500.0 17942000.0 False True 17704552.683702968 12451717.455064464 13242451.9515376 1.0 0.7033059618911617 0.7479687393473246 24.07761705783272 -10.09568994751551 5.035033020388304 1.0000076275415466 0.7256373506191376 0.9805125091559739 0.018233502547010637 1.5710160330426489e-06 2.8213136506907165e-07 0.01765500671112925 0.0058848376418468564 8.02250603527748e-11 10.09568994751551 -0.274370276922409 NLTALGLNLVASGGTAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLTALGLNLVASGGTAK 17 0 P31939-2;P31939;F8WEF0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 103056000.0 27126000.0 45203000.0 30727000.0 False True 41152125.17623586 37136171.477349035 24653794.981877472 1.0 0.9024119973953151 0.5990892299315398 25.29446360037602 -6.950651385482113 0.5516451192778754 1.0041545327519228 0.4830567417977986 0.9992514206130463 0.004670478294677715 0.08322520380536251 0.034887854084794556 0.005058578589489986 0.025171104441557256 1.1203368333429692e-07 6.950651385482113 -0.5210977909541241 NLTALGLNLVASGGTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLTALGLNLVASGGTAK 17 0 P31939-2;P31939;F8WEF0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 43080800.0 6198800.0 11031000.0 25851000.0 False True 8490663.876271253 10543613.945361085 19745526.218057077 1.0 1.2417891108405767 2.3255574011402853 23.017445930353343 -6.942269528694305 0.638099145739767 0.9881497689160009 2.6384223501693116 0.9984463270331937 0.022719706002607424 0.08674631952937639 0.05000775368826274 0.022516626020386017 0.09238536362205438 1.1421692699694358e-07 6.942269528694305 1.6502725812533106 up NLTALGLNLVASGGTAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLTALGLNLVASGGTAK 17 0 P31939-2;P31939;F8WEF0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 36535300.0 18285000.0 8677200.0 9573100.0 False True 15204787.662846094 8630454.201310657 11574790.948986663 1.0 0.5676142536603614 0.7612596246424691 23.858022333266998 -10.072248334508744 4.887744753084327 1.0000083485803348 0.6644369391978352 0.8001520368546016 0.07905539167430595 8.4413323455271e-06 1.6022351603050184e-06 0.07654728795074507 0.025515017946421092 8.467430983812195e-11 10.072248334508744 -0.33557140938249963 NLTALGLNLVASGGTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLTALGLNLVASGGTAK 17 0 P31939-2;P31939;F8WEF0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 85228000.0 27126000.0 34072000.0 24030000.0 False True 35115141.7333993 32175863.24830491 19656786.568621565 1.0 0.9162959811636262 0.5597809263553469 25.06558992246847 -6.943434294042094 0.6267984968605245 1.0038901365177981 0.45307767855590253 0.9985800240690131 0.007192688444728922 0.08623420471172687 0.04773288224286859 0.007199308222035577 0.030251173880436716 1.1391101088620828e-07 6.943434294042094 -0.5508124579618956 NLTEDNSQNQDLIAK(ub)MEEQGLADASLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLTEDNSQNQDLIAKMEEQGLADASLLK 28 1 Q9UBB4;Q9UBB4-2;B1AHE3 Q9UBB4 ATXN10 Ataxin-10 1 44185000.0 28743000.0 4596000.0 10846000.0 True False 27830569.198122732 6431206.767823375 8005107.2269745255 1.0 0.23108427003559748 0.2876372082075309 24.73016707956131 -10.377255706640565 8.874543384131712 1.000002203106447 0.25936073912156493 0.9956462524747998 0.023087640329400368 1.0063999814885259e-06 7.064175608954837e-08 0.02235457820091614 0.0074515038749161985 4.195119083969591e-11 10.377255706640565 -0.7406414639848822 NLTEDNSQNQDLIAK(ub)MEEQGLADASLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLTEDNSQNQDLIAKMEEQGLADASLLK 28 1 Q9UBB4;Q9UBB4-2;B1AHE3 Q9UBB4 ATXN10 Ataxin-10 1 161713000.0 48538000.0 74023000.0 39152000.0 True False 73635694.60311644 60813017.30566125 31413590.03906881 1.0 0.8258632940645542 0.4266081851795191 26.13390194059632 -6.957288421531222 0.4721037922632177 1.0103326965621728 0.2257132877029975 0.9996560192824644 0.004451665184647894 0.08068442045990126 0.024821457178676374 0.005542408339490319 0.03294800227353152 1.1033456280212513e-07 6.957288421531222 -0.7846194088591754 down NLTEDNSQNQDLIAK(ub)MEEQGLADASLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLTEDNSQNQDLIAKMEEQGLADASLLK 28 1 Q9UBB4;Q9UBB4-2;B1AHE3 Q9UBB4 ATXN10 Ataxin-10 1 48756700.0 28743000.0 14722000.0 5291700.0 True False 23901078.030800387 14642689.66391179 6398170.003943639 1.0 0.6126372059470425 0.26769378333891747 24.510572354995585 -7.64574572410358 0.2900609555342595 1.1055841342241746 1.1481913040805758e-12 0.9996206692158859 0.005825975614263614 0.12681549689187596 0.03731624093063039 0.03216557017365636 0.0748976261576499 2.2607590388809945e-08 7.64574572410358 -1.1055841342230264 down NLTEDNSQNQDLIAK(ub)MEEQGLADASLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLTEDNSQNQDLIAKMEEQGLADASLLK 28 1 Q9UBB4;Q9UBB4-2;B1AHE3 Q9UBB4 ATXN10 Ataxin-10 1 127724000.0 48538000.0 48925000.0 30261000.0 True False 62833397.82701966 46202280.741468504 24753808.50408059 1.0 0.7353140581170443 0.39395941267139206 25.90502826268877 -6.9676462228107585 0.3092860312539039 1.0530338725972639 0.0654001416426553 0.9999577651163127 0.0016121828328656547 0.07707409438070421 0.011750100461041912 0.00541843028130689 0.030326817478393477 1.0773424616897996e-07 6.9676462228107585 -0.9876337309546086 down NLTEDNSQNQDLIAK(ub)MEEQGLADASLLKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLTEDNSQNQDLIAKMEEQGLADASLLKK 29 2 Q9UBB4;Q9UBB4-2;B1AHE3 Q9UBB4 ATXN10 Ataxin-10 1 43493000.0 13747000.0 12923000.0 16823000.0 True False 20855204.040319774 10616789.682140145 13497926.676217163 1.0 0.5090714845855498 0.6472210317444681 24.313904091352004 -10.51110912983104 9.380306039281777 1.000010945003976 0.5781462581650233 0.9255545105410524 0.0563993164559852 1.2909835672039071e-05 6.727704531078543e-07 0.05460981782125717 0.018202801114292705 3.08241330188586e-11 10.51110912983104 -0.42186468683895273 NLTEDNSQNQDLIAK(ub)MEEQGLADASLLKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLTEDNSQNQDLIAKMEEQGLADASLLKK 29 2 Q9UBB4;Q9UBB4-2;B1AHE3 Q9UBB4 ATXN10 Ataxin-10 1 45728000.0 13747000.0 17183000.0 14798000.0 True False 17795762.493881885 16226750.944929045 12104915.840302179 1.0 0.9118322943738848 0.6802133847573996 24.085030413444454 -6.954390968048508 0.5083585920646999 1.0043209541371152 0.5775916423937768 0.9995023360329134 0.003008497217783516 0.08176901020304322 0.02902517410474043 0.0034750991085487023 0.019114058030092515 1.1107313553774652e-07 6.954390968048508 -0.4267293117433384 NLTHMQDEVNVKSHQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLTHMQDEVNVKSHQR 16 1 H0YN48;F5H2B9;H0YNH8;Q9BZF9-2;Q9BZF9 H0YN48 UACA Uveal autoantigen with coiled-coil domains and ankyrin repeats 0 2894320.0 831830.0 881390.0 1181100.0 False True 1090537.1854531784 749890.0476313105 1058891.1019112067 1.0 0.6876336338037752 0.9709811971896942 20.056607533575413 -10.355938025756389 7.926326261672566 1.0000013401990968 0.8293074158837521 0.32608671064623307 0.11567615835940251 2.739620187576098e-06 2.225663331323308e-07 0.11200383820783506 0.037334319573268146 4.406177355985359e-11 10.355938025756389 -0.1706939243153447 NLTHMQDEVNVKSHQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLTHMQDEVNVKSHQR 16 1 H0YN48;F5H2B9;H0YNH8;Q9BZF9-2;Q9BZF9 H0YN48 UACA Uveal autoantigen with coiled-coil domains and ankyrin repeats 0 15033100.0 3684600.0 4416800.0 6931700.0 False True 5589807.580342062 3628587.531384094 5561646.456727961 1.0 0.6491435490811738 0.9949620584949764 22.414367190914245 -10.85988145829439 10.079161878917102 1.0068867399740908 0.8220528037880751 0.26092383920177675 0.14117981527894627 0.02212992641548652 0.0003076452335748129 0.13846034671578616 0.045565589449666516 1.3807610951775187e-11 10.85988145829439 -0.18483393618601573 NLTHMQDEVNVKSHQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLTHMQDEVNVKSHQR 16 1 H0YN48;F5H2B9;H0YNH8;Q9BZF9-2;Q9BZF9 H0YN48 UACA Uveal autoantigen with coiled-coil domains and ankyrin repeats 0 3919030.0 831830.0 1170400.0 1916800.0 False True 1139380.0303605078 1118687.8580047695 1464091.3177351663 1.0 0.9818390951180783 1.2849894492813936 20.119817595098304 -6.892665464968185 1.0065047504516393 0.9847368409038076 1.3124642840468177 0.9825494325356495 0.01833873304551572 0.11700626226582361 0.2094392701113126 0.01383229741827987 0.0348312655732852 1.2803671853230788e-07 6.892665464968185 0.32772744314301006 NLTNPNTVIILIGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLTNPNTVIILIGNK 15 0 P61106;X6RFL8 P61106 RAB14 Ras-related protein Rab-14 0 16243000.0 4838400.0 6619000.0 4785600.0 False True 6343189.255132258 5631471.000659927 4290432.018716676 1.0 0.8877980419870838 0.676384046912253 22.59677695632667 -6.961194545862215 0.4182649413892229 1.009521272079265 0.5467084893542183 0.9998119520406185 0.001839861381527451 0.0792772239246751 0.019575394759486192 0.002731947872387881 0.017607160380056486 1.0934664290700746e-07 6.961194545862215 -0.46281278272504667 NLTNPNTVIILIGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLTNPNTVIILIGNK 15 0 P61106;X6RFL8 P61106 RAB14 Ras-related protein Rab-14 0 11640300.0 5745300.0 2899700.0 2995300.0 False True 5562918.596318224 4057565.331735734 2210741.0729261274 1.0 0.7293950579145995 0.3974066912266682 22.407410563726184 -6.9683822854526785 0.2942711914237237 1.061642024927756 0.05484108348070635 0.9999668710330537 0.001418400297805378 0.07683118004877491 0.010899099706083024 0.005670473235236451 0.02996050936505328 1.0755180776566337e-07 6.9683822854526785 -1.0068009414470498 down NLTNPNTVIILIGNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLTNPNTVIILIGNK 15 0 P61106;X6RFL8 P61106 RAB14 Ras-related protein Rab-14 0 27403100.0 4677100.0 11159000.0 11567000.0 False True 7095502.641811284 9167589.26433506 9280777.380003793 1.0 1.2920281658854869 1.3079802585535603 22.75847345701563 -12.14473201480005 0.44675166874983724 2.866484981620944e-10 1.3080590684388331 0.9998396298973617 0.0017928358367470115 6.7163327790251905 0.22415703550236146 6.330967325855801 0.0036271081902579994 7.165854491215901e-13 12.14473201480005 1.3080590681521846 NLTNPNTVIILIGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLTNPNTVIILIGNK 15 0 P61106;X6RFL8 P61106 RAB14 Ras-related protein Rab-14 0 18773200.0 4838400.0 4539400.0 9395400.0 False True 6627287.2328435965 4338834.298211594 7176400.024336917 1.0 0.6546923568830912 1.082856344111965 22.659987017849563 -6.692110877492642 1.8591476334113919 0.7839369149187762 1.0814044801627722 0.3801729845860111 0.1459798988846374 0.4121724955351405 2.7638098809221634 0.06277991502011399 0.16303561660647967 2.0318382065400693e-07 6.692110877492642 0.2974675652439961 NLTNPNTVIILIGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLTNPNTVIILIGNK 15 0 P61106;X6RFL8 P61106 RAB14 Ras-related protein Rab-14 0 11156300.0 5745300.0 2675500.0 2735500.0 False True 4777471.509945296 2661086.5504548284 3307480.4024770497 1.0 0.5570073091833674 0.6923077187570548 22.18781583916046 -10.742052275847776 10.298946862524083 1.0008276330437471 0.6246575139702132 0.9111991087415455 0.05523616090751836 0.0010515879328990526 2.6338029774173653e-05 0.05357947356890803 0.01782739427527097 1.8111220754808457e-11 10.742052275847776 -0.3761701190735339 NLTNPNTVIILIGNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLTNPNTVIILIGNK 15 0 P61106;X6RFL8 P61106 RAB14 Ras-related protein Rab-14 0 16749000.0 4677100.0 6547000.0 5524900.0 False True 6054598.149424243 6182653.694724463 4519424.890261218 1.0 1.021150131212655 0.7464450618726841 22.52959977910808 -6.888316243653758 1.0323309017622784 1.0153616111473263 0.7235862126863011 0.9797970757541765 0.0177402741573395 0.12051830407284223 0.2299325105548422 0.013122274004002229 0.03252071095917433 1.2932537796462668e-07 6.888316243653758 -0.2917753984610252 NLTNPNTVIILIGNK(ub)ADLEAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLTNPNTVIILIGNKADLEAQR 22 1 P61106;X6RFL8 P61106 RAB14 Ras-related protein Rab-14 1 29259900.0 0.0 9478900.0 19781000.0 True False 0.0 7787316.2360162735 15871276.6796797 0.0 NLTNPNTVIILIGNK(ub)ADLEAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLTNPNTVIILIGNKADLEAQR 22 1 P61106;X6RFL8 P61106 RAB14 Ras-related protein Rab-14 1 24770600.0 0.0 7869600.0 16901000.0 True False 0.0 7431649.842065626 13825191.418904409 0.0 NLTPMNYNIFFHLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLTPMNYNIFFHLLK 15 0 Q9H5Q4 Q9H5Q4 TFB2M Dimethyladenosine transferase 2, mitochondrial 0 27018300.0 8236900.0 9473400.0 9308000.0 False True 12495979.498051234 7782797.753987958 7468269.7201586645 1.0 0.6228241455743182 0.5976538070763762 23.5749606557999 -13.999999999999998 0.3846401785837518 6.763326093183915 0.5956197855091641 0.9998148907372547 0.0025037053087496163 24.63265233482994 0.2027297029179026 117.77811606877567 0.006728940056217354 1.0000000000000041e-14 13.999999999999998 -6.1677063076747505 NLTPMNYNIFFHLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLTPMNYNIFFHLLK 15 0 Q9H5Q4 Q9H5Q4 TFB2M Dimethyladenosine transferase 2, mitochondrial 0 20138800.0 8236900.0 7095600.0 4806300.0 False True 10662829.423572851 6700723.622466304 3931602.716802572 1.0 0.6284189079919705 0.3687203987443315 23.346086977892348 -8.065531953762124 0.18737007345974513 1.281519121771573 3.4406203521452745e-14 0.9998648440729587 0.003011789833771319 0.09587564838545364 0.03436522073016489 0.08987977002852861 0.10942859980826541 8.599397934105026e-09 8.065531953762124 -1.2815191217715385 down NLTVILSDASAPGEGEHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLTVILSDASAPGEGEHK 18 0 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 0 26282200.0 4466200.0 11633000.0 10183000.0 False True 6775551.922956004 9557000.260956151 8170325.586632556 1.0 1.4105124378984422 1.2058538816522046 22.691907039640125 -10.14492976375374 4.449128201002345 0.9999524875964123 1.308183159739496 0.7514544759516515 0.08355150575379919 4.008575876772094e-05 7.704097346246225e-06 0.08091107157664147 0.026966132522652904 7.162592378242385e-11 10.14492976375374 0.30823067214308364 NLTVK(ub)DFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLTVKDFR 8 1 Q5T6K7;E9PI99;A0A0A0MT00;Q5T6K5;Q13952-6;Q13952-7;Q13952-2;Q13952-5;Q13952-3;Q13952;E9PQR2;Q13952-4;E9PJA8 Q5T6K7 NFYC Nuclear transcription factor Y subunit gamma 1 11382500.0 1432400.0 1747300.0 8202800.0 True False 1877890.271381333 1486609.6509220551 7354052.942813697 1.0 0.791638187586189 3.9161249487725525 20.840681335426122 -6.890949205029035 1.0167308648821491 0.8359183433351245 4.189931362152029 0.9814995989645474 0.19400322300825318 0.11837714720703268 0.21736654993870325 0.1452015885951602 0.36325603105859433 1.2854369955324064e-07 6.890949205029035 3.3540130188169046 up NLTVK(ub)DFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLTVKDFR 8 1 Q5T6K7;E9PI99;A0A0A0MT00;Q5T6K5;Q13952-6;Q13952-7;Q13952-2;Q13952-5;Q13952-3;Q13952;E9PQR2;Q13952-4;E9PJA8 Q5T6K7 NFYC Nuclear transcription factor Y subunit gamma 1 20350700.0 4541100.0 3721600.0 12088000.0 True False 4396945.266172462 5207654.287887615 8921790.167773193 1.0 1.1843800576623675 2.029088293732527 22.06807014310443 -6.941774044145635 0.6428563951685187 0.9907323470468511 2.2692742228682374 0.9983870558666936 0.017993409582337166 0.08696671784866344 0.050995212013644105 0.01776021030629734 0.07215321520443606 1.1434731091925979e-07 6.941774044145635 1.2785418758213862 up NLTVK(ub)DFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLTVKDFR 8 1 Q5T6K7;E9PI99;A0A0A0MT00;Q5T6K5;Q13952-6;Q13952-7;Q13952-2;Q13952-5;Q13952-3;Q13952;E9PQR2;Q13952-4;E9PJA8 Q5T6K7 NFYC Nuclear transcription factor Y subunit gamma 1 46368700.0 7421700.0 14657000.0 24290000.0 True False 11259261.49894823 12041343.834336296 19489070.853314806 1.0 1.0694612462337005 1.7309368696282037 23.42460886758479 -6.927004605007477 0.7709715202715521 0.9887460264136086 1.8569303294466246 0.9959164365154058 0.021050694713179604 0.09422253907211577 0.08551657042433677 0.018847154376217843 0.060867261935042966 1.1830290115033205e-07 6.927004605007477 0.868184303033016 NLTVK(ub)DFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLTVKDFR 8 1 Q5T6K7;E9PI99;A0A0A0MT00;Q5T6K5;Q13952-6;Q13952-7;Q13952-2;Q13952-5;Q13952-3;Q13952;E9PQR2;Q13952-4;E9PJA8 Q5T6K7 NFYC Nuclear transcription factor Y subunit gamma 1 17629000.0 4541100.0 4483000.0 8604900.0 True False 3776125.854840051 4458849.189194168 10404144.80543769 1.0 1.1807999416860102 2.7552431262591983 21.848475418538705 -6.92855279908259 0.7585764439619416 0.9747282135965883 3.066871021678646 0.9962461348533003 0.048296835953798786 0.09339614208436478 0.08141248873646112 0.043627875646283766 0.1436101797959953 1.1788192003177688e-07 6.92855279908259 2.0921428080820577 up NLTVK(ub)DFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLTVKDFR 8 1 Q5T6K7;E9PI99;A0A0A0MT00;Q5T6K5;Q13952-6;Q13952-7;Q13952-2;Q13952-5;Q13952-3;Q13952;E9PQR2;Q13952-4;E9PJA8 Q5T6K7 NFYC Nuclear transcription factor Y subunit gamma 1 42253700.0 7421700.0 13357000.0 21475000.0 True False 9607536.95357847 12613671.208253361 17566770.35210768 1.0 1.312893332515907 1.828436407477431 23.19573518967724 -6.963649941890539 0.3805117565507662 0.9647902982466858 2.1947851890239574 0.9998825537999529 0.003701613457157023 0.07842212400290671 0.016493993811043627 0.006705797512085263 0.043552257949607175 1.0873016776081475e-07 6.963649941890539 1.2299948907772715 NLTWTLSNLCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLTWTLSNLCR 11 0 P52292 P52292 KPNA2 Importin subunit alpha-1 0 87312000.0 20389000.0 32671000.0 34252000.0 False True 26730176.447356857 27796614.150560565 30707931.608384296 1.0 1.0398963959442609 1.1488114067956618 24.67196602513284 -6.953550531140132 0.5184093302303829 0.9981262348714465 1.1954288188099373 0.9994512174470752 0.0014733118571679826 0.08209071572280258 0.030299570782742907 0.0016733317954176698 0.00899505254267261 1.1128828988392147e-07 6.953550531140132 0.19730258393849087 NLTWTLSNLCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLTWTLSNLCR 11 0 P52292 P52292 KPNA2 Importin subunit alpha-1 0 80370000.0 16723000.0 34864000.0 28783000.0 False True 25370013.615062743 28642246.806324672 23094027.43396295 1.0 1.1289803482533067 0.9102883342660687 24.59662095784982 -6.746869977543694 1.6612607705574973 1.0761245314603984 0.9099506518004443 0.6354846603942026 0.054192168511450284 0.3055255248156858 1.657931362455364 0.025779433160378666 0.06279666707405829 1.7911420197849748e-07 6.746869977543694 -0.16617387965995412 NLTWTLSNLCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLTWTLSNLCR 11 0 P52292 P52292 KPNA2 Importin subunit alpha-1 0 86133000.0 20389000.0 27610000.0 38134000.0 False True 27927364.29200725 26390098.90593957 29127534.594382748 1.0 0.9449548704276529 1.0429747071662965 24.73517608665573 -6.754281021340108 1.6336347300449714 0.9678017428549727 1.0432397289162987 0.6673775661838713 0.023137101904805772 0.29261176189767724 1.5375984451384126 0.011181475412656667 0.027028628418777446 1.7608362835909674e-07 6.754281021340108 0.07543798606132601 NLTWTLSNLCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLTWTLSNLCR 11 0 P52292 P52292 KPNA2 Importin subunit alpha-1 0 85257000.0 16723000.0 36372000.0 32162000.0 False True 21648253.15961204 34347866.22644237 26308846.009987786 1.0 1.5866345415122591 1.215287248167938 24.367747279942268 -10.382268657792661 6.188250452928029 0.999939689105658 1.4009608948400514 0.6085293087948382 0.15160189767620205 0.00012617257235788277 1.2595149158983105e-05 0.14680987674910442 0.048929302079447554 4.1469742836103526e-11 10.382268657792661 0.40102120573439337 NLTYSAPLYVDITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLTYSAPLYVDITK 14 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 3940600.0 1163700.0 1519600.0 1257300.0 False True 1525621.9692868316 1292881.6033544058 1127206.6568732196 1.0 0.847445585723164 0.7388505668938057 20.540966093358165 -6.974793836689958 0.08580178087304939 1.342754877636198 0.24080835203805392 0.9999998627847652 3.925627691321622e-05 0.07477554801910766 0.002496845527798764 0.011957928185910864 0.019958175419505043 1.0597566813618882e-07 6.974793836689958 -1.101946525598144 NLTYSAPLYVDITK(ub)TVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLTYSAPLYVDITKTVIK 18 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 12312100.0 1100500.0 7467400.0 3744200.0 True False 1442766.1572571588 6353293.0276972195 3356786.1009025006 1.0 4.403550080336967 2.3266321323228727 20.460406056884516 -9.949882625916134 9.011706715355864 0.9999999991918661 3.36509110632992 0.6335658439910976 0.8478982017104685 1.22950840233601e-08 2.715016101967215e-09 0.8209738975092332 0.27365796787532176 1.1223217362720624e-10 9.949882625916134 2.365091107138054 NLTYSAPLYVDITK(ub)TVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLTYSAPLYVDITKTVIK 18 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 32388400.0 7804400.0 12456000.0 12128000.0 True False 7556653.593912573 17429745.757181875 8951312.967798902 1.0 2.3065429082554196 1.1845604481605227 22.84931605875781 -6.609103822041102 2.1566794572372743 1.873424050685964 1.1885170133526708 0.0476596011957896 0.5634205651210916 0.6151833241589278 5.420751286644793 0.21581295005273662 0.6257193300180887 2.459779501219943e-07 6.609103822041102 -0.6849070373332933 NLTYSAPLYVDITK(ub)TVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLTYSAPLYVDITKTVIK 18 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 91015000.0 15187000.0 18441000.0 57387000.0 True False 23039789.31842123 15150059.469809357 46044434.29638439 1.0 0.6575606773320745 1.9984746240526612 24.45762418868887 -6.83896584060577 1.2871583868060217 0.8177991354344321 2.041692817075659 0.9226713323815842 0.15818473242342035 0.17000546076591347 0.5475715193121015 0.09638125653000551 0.22198984589880885 1.4488858110489233e-07 6.83896584060577 1.223893681641227 NLTYSAPLYVDITK(ub)TVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLTYSAPLYVDITKTVIK 18 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 13005300.0 1100500.0 5083900.0 6820900.0 True False 1507384.5898942552 4859276.48779089 5209943.900845058 1.0 3.2236474489445155 3.4562804580684627 20.523616118407407 -10.212377191121437 0.492913802090262 3.6925219230564454e-12 3.4505909131809025 0.999396217410364 0.027204887733273245 1.5331867079553636 0.22941470640905906 2.176702506698497 0.04778278524602409 6.13229175288361e-11 10.212377191121437 3.45059091317721 NLTYSAPLYVDITK(ub)TVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLTYSAPLYVDITKTVIK 18 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 25601800.0 7804400.0 9160400.0 8637000.0 True False 6489704.39354203 9111051.107002962 10442956.767024038 1.0 1.4039239007664912 1.6091575415077348 22.629721334192087 -11.042940163590991 0.12320580316752823 9.15734226234739e-19 1.98907942074349 0.9997900147125359 0.0036670357136501025 3.3764178904525033 0.0743533154260992 1.208993887375044 0.25632264810333766 9.058573999050834e-12 11.042940163590991 1.98907942074349 NLTYSAPLYVDITK(ub)TVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLTYSAPLYVDITKTVIK 18 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 87077000.0 15187000.0 19899000.0 51991000.0 True False 19659870.880525526 18791603.15737318 42529171.47270918 1.0 0.9558355327749163 2.163247751277822 24.22875051078132 -6.898406900059138 0.9712568652340089 0.9475824308685153 2.2859762456570643 0.9857577354937525 0.0667188434131944 0.11258841864821477 0.18409500707991708 0.05166951235176683 0.13339622775659576 1.263551943083626e-07 6.898406900059138 1.338393814788549 up NLVCTDLFTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLVCTDLFTR 10 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 5997000.0 1572400.0 2353300.0 2071300.0 False True 2061431.6271432606 2002196.8130915524 1856981.7453125736 1.0 0.9712652055630892 0.9008214101604649 20.97521518052969 -6.955880336153881 0.4900609505690995 1.0015407582884372 0.8675584374938756 0.9995855485734622 0.0008482176666982394 0.08120699491667376 0.026829429695290088 0.0010143750970760803 0.005809989838810032 1.106928740888326e-07 6.955880336153881 -0.13398232079456163 NLVDSYVAIINK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLVDSYVAIINK 12 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 0 8007500.0 2023000.0 3386400.0 2598100.0 False True 2652172.590759866 2881162.320083811 2329273.534735001 1.0 1.086340432791494 0.8782511148973333 21.33874323155124 -6.794002242944389 1.4801433272220537 1.0480055658124834 0.875782228522292 0.814083071695803 0.036806062885260574 0.2294329801811018 0.9928286262410323 0.019568010199108372 0.04568680684008921 1.606932953873216e-07 6.794002242944389 -0.17222333729019135 NLVDSYVAIINK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLVDSYVAIINK 12 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 0 7611200.0 2023000.0 2721800.0 2866400.0 False True 2770957.7695193803 2601541.8762110253 2189415.3553610626 1.0 0.9388601677109861 0.7901294561197207 21.401953293074133 -6.9560444390373695 0.487998448475233 1.0033146812286111 0.7193894595032494 0.9995941969701849 0.0017753615545223675 0.08114558963171405 0.026591611319615918 0.00213224991696242 0.012266952959582838 1.1065105548628609e-07 6.9560444390373695 -0.2839252217253617 NLVDSYVAIINK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLVDSYVAIINK 12 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 0 5320100.0 2676600.0 1074600.0 1568900.0 False True 2225711.493485036 1068810.9165086013 1896949.7362260097 1.0 0.48021089868887235 0.8522891406988924 21.085835165645637 -9.994881888632293 6.782785802215945 1.00000005080663 0.6662500196938852 0.5175572914456239 0.1519003062193942 1.1665369765993793e-07 1.7448182765042365e-08 0.14707686317555949 0.04902561302262613 1.0118546023130897e-10 9.994881888632293 -0.3337500311127448 NLVDSYVAIINK(ub)SIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLVDSYVAIINKSIR 15 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 1 4769000.0 1061800.0 1613400.0 2093800.0 True False 1028093.7401999347 2257639.033769851 1545370.9673464166 1.0 2.195946678296869 1.5031420841506984 19.97154038284036 -10.246880115617028 5.489211994235464 0.9999376075462744 1.849544381223814 0.6672085087451378 0.2828362911858455 0.0002159881465782552 2.963236463892787e-05 0.2738749993602525 0.09128502045546427 5.663956175684408e-11 10.246880115617028 0.8496067736775396 NLVDSYVAIINK(ub)SIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLVDSYVAIINKSIR 15 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 1 9277650.0 991750.0 2095600.0 6190300.0 True False 1504557.2566368778 1721623.8070024692 4966784.491695125 1.0 1.1442727084051278 3.301160171728745 20.520907579481165 -6.9204657732693216 0.8212646045064291 0.9532039094853755 3.6527318422108657 0.9943093182355865 0.07939109618211387 0.09789856903561173 0.1041998138841064 0.06857270941063007 0.20633151705097572 1.2009757181332509e-07 6.9204657732693216 2.6995279327254904 up NLVDSYVAIINK(ub)SIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLVDSYVAIINKSIR 15 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 1 3967900.0 1061800.0 1503500.0 1402600.0 True False 882933.7457156127 1495400.347078615 1695877.1751103294 1.0 1.6936722085150362 1.9207298207135926 19.751945658274636 -10.875751089903668 0.22134056860271822 6.601228197809458e-15 2.0680155170685595 0.9992909544392246 0.010428714097807747 2.8072609255675167 0.11844708686097936 1.5800239626744277 0.12251724451822481 1.3312171687618693e-11 10.875751089903668 2.068015517068553 NLVGK(ub)VIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLVGKVIGK 9 1 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85;P51116;A8MQB8;Q06787-2;A0A087WXI3;Q06787-11;Q06787-8;Q06787-9;R9WNI0;Q06787-6;Q06787-4;Q06787-7;Q06787-10;Q06787-5;Q06787-3;Q06787 B4DXZ6;A8MQB8;Q06787-6 FXR1;FXR2;FMR1 Fragile X mental retardation syndrome-related protein 1;Fragile X mental retardation syndrome-related protein 2;Fragile X mental retardation protein 1 1 3593060.0 845360.0 1505500.0 1242200.0 True False 818524.50952667 2106654.001078783 916830.5547987976 1.0 2.573721344394443 1.1201015291881429 19.642666091188993 -6.627320033024702 2.0898876051209876 2.038789932445564 1.1258500046525097 0.10802910565920165 0.6754968672402867 0.5660148678508615 4.707350027096423 0.2646634243339489 0.7485635252743117 2.3587394297908294e-07 6.627320033024702 -0.9129399277930541 NLVGK(ub)VIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLVGKVIGK 9 1 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85;P51116;A8MQB8;Q06787-2;A0A087WXI3;Q06787-11;Q06787-8;Q06787-9;R9WNI0;Q06787-6;Q06787-4;Q06787-7;Q06787-10;Q06787-5;Q06787-3;Q06787 B4DXZ6;A8MQB8;Q06787-6 FXR1;FXR2;FMR1 Fragile X mental retardation syndrome-related protein 1;Fragile X mental retardation syndrome-related protein 2;Fragile X mental retardation protein 1 1 3285430.0 845360.0 1980500.0 459570.0 True False 702954.2957978448 1969830.6534015306 555663.9621884036 1.0 2.802217249651766 0.7904695447628378 19.42307136662327 -6.670538864005532 1.935324470775776 2.1498075347950647 0.7985599189636385 0.28148776099672557 0.7654464833112573 0.45988618219070426 3.321284831790285 0.3183412529880567 0.8499736393054291 2.135310993470912e-07 6.670538864005532 -1.3512476158314262 NLVLLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLVLLVR 7 0 Q9H2W6 Q9H2W6 MRPL46 39S ribosomal protein L46, mitochondrial 0 3715480.0 1300900.0 1456900.0 957680.0 False True 1705492.4979335188 1239536.1989517212 858588.460315236 1.0 0.7267907659832105 0.5034255274388808 20.701756978208113 -7.01327504621002 0.15861023306698635 1.2331652207918113 1.6537360734759332e-08 0.9999982668665848 0.00026727079727019025 0.07224541232685242 0.0048470681123775755 0.010536395611504632 0.02633250998642936 9.698955210806563e-08 7.01327504621002 -1.2331652042544505 NLVLLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLVLLVR 7 0 Q9H2W6 Q9H2W6 MRPL46 39S ribosomal protein L46, mitochondrial 0 9596600.0 2212900.0 4928500.0 2455200.0 False True 3357131.0846601906 4048970.668453741 1969928.6438476108 1.0 1.2060805986858205 0.5867893133064858 21.678797439841016 -6.817006391646705 1.3848807261581002 1.1114215516809363 0.5741289972318576 0.8773406941668779 0.09018189988445681 0.19739725730952565 0.7447132955664922 0.05118383372314747 0.11806908740112747 1.5240303240048652e-07 6.817006391646705 -0.5372925544490786 NLVLLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLVLLVR 7 0 Q9H2W6 Q9H2W6 MRPL46 39S ribosomal protein L46, mitochondrial 0 5890600.0 1300900.0 2203900.0 2385800.0 False True 1781877.8855006234 2106524.4106773 1822323.1770933669 1.0 1.1821934756687695 1.0226981275887939 20.764967039731005 -10.738282391826017 3.0840089270451423 0.9840287883715386 1.102445801661234 0.3548747269076904 0.06511370336488588 24285034.30681288 14795368.481628004 2807881.953576821 0.023829173872830747 1.82691191470629e-11 10.738282391826017 0.11841701328969534 NLVNDDDAIVAASK(ub)CLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLVNDDDAIVAASKCLK 17 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 84669000.0 15574000.0 25753000.0 43342000.0 True False 23626896.611911003 21157175.94089261 34775434.702526584 1.0 0.8954699505573942 1.471857911503929 24.493926808265762 -6.859968901213416 1.1860270070289807 0.9432965441555315 1.4997335440617103 0.9535849385448609 0.05401812282633603 0.14683800945550496 0.3925246838490274 0.035525301847299684 0.08291633026535497 1.3804831141496084e-07 6.859968901213416 0.5564369999061788 NLVNDDDAIVAASK(ub)CLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLVNDDDAIVAASKCLK 17 1 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 63799000.0 15574000.0 17650000.0 30575000.0 True False 20160850.009436008 16667761.984403074 25010663.72599268 1.0 0.8267390500203096 1.2405560139719696 24.26505313035821 -6.792958277741354 1.4843280548925144 0.9035358081636434 1.2453333327188307 0.8108183108178026 0.07380367814292267 0.23096725136835244 1.0051775445606077 0.0391292688733801 0.09142431032892531 1.610800375808398e-07 6.792958277741354 0.3417975245551873 NLVNK(ub)HSETFTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLVNKHSETFTR 12 1 Q9UNS2;Q9UNS2-2 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 20826200.0 9870900.0 6291900.0 4663400.0 True False 12940845.489931587 5353173.045634103 4180876.1024915087 1.0 0.41366486059964563 0.32307596174796854 23.62542854307853 -13.999999999999998 0.26290767622872885 5.358112885345921 0.2908769645301822 0.9995683226196312 0.006233903277632481 14.547610704964361 0.162268367057627 33.742319886849195 0.039006804761388354 1.0000000000000041e-14 13.999999999999998 -5.067235920815739 NLVNK(ub)HSETFTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLVNKHSETFTR 12 1 Q9UNS2;Q9UNS2-2 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 25558900.0 6703600.0 9290100.0 9565200.0 True False 6490797.887365123 12999685.377231488 7059787.170150893 1.0 2.002786961297386 1.0876609151385463 22.629964403078855 -6.624391133578057 2.100674225278671 1.6633317187926946 1.091246277756325 0.09767396991580712 0.430755726098992 0.5737983225244822 4.8174860752186905 0.16813859539735201 0.47742573610482814 2.3747006243109385e-07 6.624391133578057 -0.5720854410363696 NLVNK(ub)HSETFTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLVNKHSETFTR 12 1 Q9UNS2;Q9UNS2-2 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 46555000.0 12972000.0 16723000.0 16860000.0 True False 19679472.38023049 13738649.99260462 13527613.6099995 1.0 0.6981208503540027 0.6873971694276217 24.23018820579169 NLVPGESVYGEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLVPGESVYGEKR 13 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 10251600.0 2673700.0 2965800.0 4612100.0 True False 3505246.5921476353 2523314.200597852 4134884.134387163 1.0 0.7198678136512611 1.1796271747756708 21.741084509923713 -6.741799196844267 1.680199087218109 0.8336708723711149 1.1799993994147178 0.6129673150706678 0.11769567138057918 0.3145642197047071 1.7443552724376652 0.05540126432283807 0.1356774247343778 1.8121777889786802e-07 6.741799196844267 0.34632852704360284 NLVPGESVYGEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLVPGESVYGEKR 13 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 14523500.0 4708700.0 2492200.0 7322600.0 True False 4559224.895912064 3487348.456651312 5404591.386708792 1.0 0.7648994152006345 1.1854189056465954 22.1203571450578 -6.75500411413458 1.6314742736659973 0.8625938286996687 1.1865767714443294 0.6701643785529693 0.09882509625323349 0.29139330886653597 1.5274326165493979 0.04782339687713198 0.11549216037242918 1.7579069609723586e-07 6.75500411413458 0.32398294274466066 NLVPGESVYGEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLVPGESVYGEKR 13 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 9175000.0 2673700.0 2259300.0 4242000.0 True False 3662239.144025695 2159476.6554939994 3240126.966732353 1.0 0.5896601971001291 0.8847393191179379 21.804294571446604 -9.934035092204647 6.296044895021893 1.0000000510814062 0.7371997581090136 0.5139922014847602 0.12046554711541953 8.643109934740124e-08 1.463109499287842e-08 0.11664028703733238 0.03888008814747155 1.1640319685827851e-10 9.934035092204647 -0.2628002929723926 NLVPGESVYGEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLVPGESVYGEKR 13 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 12689900.0 4708700.0 4269900.0 3711300.0 True False 3915492.6807789635 4246897.201191205 4487315.670887618 1.0 1.0846392899772475 1.1460411337034844 21.900762420492075 -6.974615366754697 0.09781065581703166 0.8426413197583669 1.3895945631969646 0.9999997585575119 2.8847144455682747e-05 0.07483116822966687 0.002867056354476337 0.005705411350299773 0.010229468502139178 1.0601922696118877e-07 6.974615366754697 0.5469532434385977 NLVPGESVYGEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLVPGESVYGEKR 13 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 28084100.0 7677100.0 4740000.0 15667000.0 True False 9938157.288265124 4476214.83320513 12815766.756995171 1.0 0.45040692186373416 1.28955161256382 23.244546944499014 -6.729974393215312 1.7230781968426492 0.6692581002676672 1.2890755702584153 0.5592910852664607 0.23103573962555915 0.33626785351913036 1.9558592604030338 0.10625090265991435 0.26368675085689663 1.8621969319103394e-07 6.729974393215312 0.6198174699907482 NLVVINKPYGLPVHGGPGVQLCITDVLPILAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLVVINKPYGLPVHGGPGVQLCITDVLPILAK 32 1 Q96CM3;Q96CM3-2;E9PJV3 Q96CM3 RPUSD4 RNA pseudouridylate synthase domain-containing protein 4 0 27209300.0 14763000.0 5868700.0 6577600.0 False True 19110994.52223602 5542101.685998085 5380544.291875372 1.0 0.28999546201270376 0.28154182586442594 24.18789952127963 NLVVIPK(ub)SVTPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLVVIPKSVTPER 13 1 P15121 P15121 AKR1B1 Aldose reductase 1 56656600.0 17462500.0 20320200.0 18873900.0 True False 22893506.60709057 17288505.367519233 16921009.879232854 1.0 0.7551706981474233 0.7391183085072727 24.44843512217715 -13.999999999999998 0.38724200219278193 4.80351031083781 0.737883292029365 0.9998189288996294 0.0016063615121869157 24.975178509962625 0.20366938963848 79.42462050710319 0.004258462393984364 1.0000000000000041e-14 13.999999999999998 -4.065627018808445 NLVVIPK(ub)SVTPER ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLVVIPKSVTPER 13 1 P15121 P15121 AKR1B1 Aldose reductase 1 91138200.0 28592000.0 26720200.0 35826000.0 True False 27684362.61046953 37389715.20400217 26442095.843037874 1.0 1.350571646892904 0.9551274925519917 24.722567970645482 -6.672790177349397 1.927779674748585 1.2232314905915336 0.9567147001924199 0.29138090607891065 0.14882037503217752 0.45471473556796915 3.260610853804767 0.06209449937545767 0.1652817464174801 2.124270522510225e-07 6.672790177349397 -0.2665167903991137 NLVVIPK(ub)SVTPER ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLVVIPKSVTPER 13 1 P15121 P15121 AKR1B1 Aldose reductase 1 160989000.0 55787000.0 39247000.0 65955000.0 True False 84632957.5760034 32243066.211789403 52918965.340896524 1.0 0.380975297747736 0.6252760964116539 26.334716248033033 -10.284118493145467 5.659368272763867 1.000044137674723 0.5031256970797118 0.846518983543314 0.09973538341352492 5.5547796371925804e-05 7.026595427518887e-06 0.09657691547707015 0.03218945658234595 5.198541398926313e-11 10.284118493145467 -0.49691844059501133 NLVVIPK(ub)SVTPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLVVIPKSVTPER 13 1 P15121 P15121 AKR1B1 Aldose reductase 1 67110900.0 17462500.0 28961000.0 20687400.0 True False 23918858.156318463 27681407.258780055 15801462.190376949 1.0 1.1573047123684568 0.6606277811051275 24.51164518370004 -6.821545170495072 1.3651942389318816 1.084658420778493 0.6494239012162086 0.8878825385328768 0.06939845581006793 0.19149194333834368 0.7008555105881619 0.03994226912932988 0.09202388131681331 1.5081857376300011e-07 6.821545170495072 -0.4352345195622844 NLVVIPK(ub)SVTPER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLVVIPKSVTPER 13 1 P15121 P15121 AKR1B1 Aldose reductase 1 76551100.0 28592000.0 32341000.0 15618100.0 True False 23775514.84036618 32166772.613814127 18883772.500064652 1.0 1.3529369534072604 0.7942529373960683 24.50297324607976 -6.735953313244601 1.7013383024555098 1.21097019010142 0.794194090047885 0.5867374356331989 0.1483100204294763 0.32517698254295724 1.846463500129668 0.06900545292983706 0.17010257035062123 1.8367357822493633e-07 6.735953313244601 -0.41677610005353505 NLVVIPK(ub)SVTPER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLVVIPKSVTPER 13 1 P15121 P15121 AKR1B1 Aldose reductase 1 124797000.0 55787000.0 41335000.0 27675000.0 True False 72217371.22617213 39034670.913614735 22638433.96947987 1.0 0.5405163640111601 0.31347629503960023 26.105842570125482 -10.357187590395005 0.15254617591272424 1.7972557533302507 4.482491739424857e-21 0.9996907398737895 0.005022092026029634 2.075327579127731 0.0770483299821262 0.8286969255537713 0.1979313268577185 4.3935179957877335e-11 10.357187590395005 -1.7972557533302507 NLVVK(ub)ENCSPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLVVKENCSPK 11 1 P53794 P53794 SLC5A3 Sodium/myo-inositol cotransporter 1 2305900.0 1218800.0 1087100.0 0.0 True False 1597858.6028759878 924908.917482611 0.0 1.0 0.5788427810933122 0.0 20.60770831679208 -7.7053557571490225 0.6456755445141424 1.0004614613181209 4.848261507889859e-19 0.9875086865466973 0.045816380492154835 0.1199880061828909 0.15136249909152022 0.042821994849687725 0.07786457596130514 1.9708076657125075e-08 7.7053557571490225 -1.0004614613181209 down NLVVK(ub)ENCSPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLVVKENCSPK 11 1 P53794 P53794 SLC5A3 Sodium/myo-inositol cotransporter 1 2717730.0 1218800.0 752040.0 746890.0 True False 1669423.296831547 718812.386136284 570489.9646823975 1.0 0.4305752696158856 0.3417287669131904 20.670918378314973 -13.999999999999998 0.2615046166583692 5.201363824120583 0.3097209014532184 0.9995654194923747 0.0060795957981334995 14.484103157525933 0.16182868629268424 32.186725393600454 0.038536952780465025 1.0000000000000041e-14 13.999999999999998 -4.891642922667365 NLVVK(ub)ENCSPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLVVKENCSPK 11 1 P53794 P53794 SLC5A3 Sodium/myo-inositol cotransporter 1 1765110.0 916130.0 0.0 848980.0 True False 1185948.3446221005 0.0 694474.3512704256 1.0 0.0 0.585585666036507 20.177609742293694 -10.030197340156864 6.3875577992292945 1.0000004517270629 0.2927928330182451 0.6604060857054714 0.23906434707957766 1.537676093795473e-06 2.343559547474692e-07 0.2314732035844833 0.07715768624259159 9.328303333700074e-11 10.030197340156864 -0.7072076187088178 NLYHNLCTSLFPTIHGNDEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLYHNLCTSLFPTIHGNDEVK 21 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 40418700.0 8460300.0 14683200.0 17275200.0 False True 11091535.229661755 12492523.794665327 15487728.019419596 1.0 1.126311510173718 1.396355662108996 23.402955733491826 -6.958719839794875 0.4531154467744604 0.9915636552653849 1.5418647433734618 0.999719731207127 0.0027676537886171374 0.08016162891989338 0.02284524532140575 0.0036265824098353164 0.022327200094020866 1.0997150288118092e-07 6.958719839794875 0.5503010881080769 NLYHNLCTSLFPTIHGNDEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLYHNLCTSLFPTIHGNDEVK 21 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 62830800.0 8460300.0 20790200.0 33580300.0 False True 11588301.541010803 19871620.22000239 25649324.74798742 1.0 1.714800063639789 2.2133808528553467 23.466165795014717 -7.83313931042365 0.12606286738999392 3.820726569867121e-19 3.509389968523661 0.9999817645826635 0.0021264936833196454 0.12983311174620515 0.01795495834089266 0.20282812855629076 0.2628646327965757 1.4684551596974026e-08 7.83313931042365 3.509389968523661 NLYHNLCTSLFPTIHGNDEVKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLYHNLCTSLFPTIHGNDEVKR 22 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 66827600.0 12425500.0 36795000.0 17607100.0 False True 16289950.82871315 31305329.425786648 15785286.19122921 1.0 1.9217571467807593 0.9690198796306736 23.957478913300335 -6.653715328099261 1.9952307966947835 1.596374645964854 0.9730277147744473 0.2091935313999509 0.39306182983580845 0.4995488158382877 3.815964286036513 0.15953547189843376 0.4354779624237144 2.219650882652257e-07 6.653715328099261 -0.6233469311904067 NLYHNLCTSLFPTIHGNDEVKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLYHNLCTSLFPTIHGNDEVKR 22 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 30413700.0 16409600.0 8293400.0 5710700.0 False True 15888686.230160903 11604997.869509665 4214896.352672269 1.0 0.7303937972845312 0.2652765805565024 23.92149650333537 -7.059839928702372 0.4165538233794679 1.0226556043382198 6.0543802446317025e-15 0.9998176946991622 0.004097446787700316 0.07371523493125434 0.019746420342665022 0.0063187218807482974 0.03640845442664049 8.71284666953069e-08 7.059839928702372 -1.0226556043382138 down NLYHNLCTSLFPTIHGNDEVKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLYHNLCTSLFPTIHGNDEVKR 22 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 79726000.0 11034000.0 41082000.0 27610000.0 False True 16739384.693452284 33750596.124868944 22152871.39810708 1.0 2.016238753272138 1.3233981895865214 23.996743162468977 -10.50120025210835 4.954255060711609 0.9977365237429693 1.6698184714293616 0.5548028815229473 0.2828509756887836 0.00709066058934884 0.0007138945969838256 0.27460997920924746 0.09128975985841553 3.153550193911375e-11 10.50120025210835 0.6720819476863923 NLYHNLCTSLFPTIHGNDEVKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLYHNLCTSLFPTIHGNDEVKR 22 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 166706500.0 12425500.0 38709000.0 115572000.0 False True 17019543.136511642 36998708.38645475 88276273.88005462 1.0 2.1738955088096494 5.186759313807755 24.020688974823226 -6.95489611154695 0.5022254743780874 0.9408082975868035 6.550286784332474 0.9995316025345864 0.03816308589616395 0.08157725665072336 0.02827168273090286 0.04457034799297283 0.24855470651126552 1.1094401749293432e-07 6.95489611154695 5.609478486745671 NLYHNLCTSLFPTIHGNDEVKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLYHNLCTSLFPTIHGNDEVKR 22 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 45622000.0 16409600.0 2088400.0 27124000.0 False True 13645309.468539193 2077149.3746850572 32795502.99279383 1.0 0.15222442403920267 2.4034268382411974 23.701901778769646 -6.804672150882401 1.4366534990089566 0.534981921272594 2.4382492513369693 0.8455074517300385 0.3648868452034309 0.2141505906098555 0.8720487550760331 0.19976038622805684 0.4633340442227793 1.5679342577984418e-07 6.804672150882401 1.9032673300643754 NLYHNLCTSLFPTIHGNDEVKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLYHNLCTSLFPTIHGNDEVKR 22 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 52037000.0 11034000.0 16067000.0 24936000.0 False True 14283730.512656787 15172857.325971916 20397903.86496657 1.0 1.0622475208788962 1.4280515756644965 23.767869484561427 -6.936276010441992 0.6933400026630924 0.9955122689903737 1.5167535458757704 0.9976343627748883 0.009184342845281244 0.089507234394518 0.06265793651110721 0.008705641112851567 0.03203441755192829 1.1580411436273809e-07 6.936276010441992 0.5212412768853967 NLYIISVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLYIISVK 8 0 P62829;C9JD32;J3KT29;B9ZVP7 P62829 RPL23 60S ribosomal protein L23 0 247569500.0 64412000.0 69691500.0 113466000.0 False True 84444755.76669529 59293799.855339386 101725626.76272716 1.0 0.7021608306755818 1.2046411389213512 26.331504495002488 -6.746113336504242 1.6641847468832438 0.8240529799281636 1.2053537031019557 0.6320945127900542 0.12513748935220745 0.3068752176288849 1.670893890728904 0.05943160311348724 0.1448800774184193 1.7942653217892844e-07 6.746113336504242 0.38130072317379204 NLYIISVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLYIISVK 8 0 P62829;C9JD32;J3KT29;B9ZVP7 P62829 RPL23 60S ribosomal protein L23 0 200122000.0 65699100.0 29692900.0 104730000.0 False True 63613518.0323692 41549429.81642796 77298071.16734654 1.0 0.6531540952551294 1.2151202064946962 25.922830038619917 -6.739736626666838 1.68765551996237 0.7935657527270789 1.2154312911165321 0.6037666583576546 0.14573068749524878 0.3182905502596166 1.7799146434383 0.06831498621587977 0.16768765872120356 1.820804731790862e-07 6.739736626666838 0.4218655383894533 NLYIISVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NLYIISVK 8 0 P62829;C9JD32;J3KT29;B9ZVP7 P62829 RPL23 60S ribosomal protein L23 0 160135700.0 40352400.0 59633800.0 60149500.0 False True 61217540.95559767 48991682.468993984 48260924.96053765 1.0 0.800288311229761 0.7883512504290606 25.867441758693946 NLYIISVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLYIISVK 8 0 P62829;C9JD32;J3KT29;B9ZVP7 P62829 RPL23 60S ribosomal protein L23 0 198762700.0 64412000.0 67022700.0 67328000.0 False True 88226857.06884944 64061415.4995697 51426513.06368607 1.0 0.7260988051470336 0.5828895505543675 26.39471455652538 -13.99999999999293 0.08182910619052072 2.4611230793420478 0.1693386602113462 0.9998790151023157 0.0019034053555109878 12.240521774634177 0.08101397796988703 3.2110226325612836 0.3747415229766793 1.0000000000162791e-14 13.99999999999293 -2.2917844191307015 NLYIISVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLYIISVK 8 0 P62829;C9JD32;J3KT29;B9ZVP7 P62829 RPL23 60S ribosomal protein L23 0 121685400.0 65699100.0 27148300.0 28838000.0 False True 54631712.61362279 27002046.719384395 34867892.468153246 1.0 0.4942559079257429 0.6382353911317563 25.703235314054194 -10.588405779056037 9.73781550178979 1.0000425809413753 0.5662456495287683 0.9236705881734446 0.058779377880725445 5.434336743024512e-05 2.296929825827775e-06 0.05691842334439031 0.018970962636040187 2.579848606364354e-11 10.588405779056037 -0.433796931412607 NLYIISVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NLYIISVK 8 0 P62829;C9JD32;J3KT29;B9ZVP7 P62829 RPL23 60S ribosomal protein L23 0 169133500.0 40352400.0 78157000.0 50624100.0 False True 52236977.26472108 73807494.2444753 41411033.24713081 1.0 1.4129357805380165 0.7927532452207622 25.638568080786396 -6.727229317035762 1.7334507563551536 1.249265454715441 0.7933119165051168 0.5463533418110476 0.17362895994604816 0.3414407756763371 2.008702005773087 0.07942032221980097 0.19768845644039448 1.8740047310745663e-07 6.727229317035762 -0.45595353821032414 NLYIISVK(ub)GIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLYIISVKGIK 11 1 P62829;C9JD32;J3KT29;B9ZVP7 P62829 RPL23 60S ribosomal protein L23 1 15616000.0 3324800.0 3602300.0 8688900.0 True False 3219256.043903505 5040717.175746327 6413016.428587391 1.0 1.5658018831065739 1.992080263616216 21.61829589562084 -6.974252657462809 0.11864886130448563 0.2170006239836559 3.351824031347715 0.9999994736358654 0.0002947528236360251 0.07494531241718873 0.003529537404171781 0.030505159439536685 0.06191983588456416 1.0610780791874789e-07 6.974252657462809 3.134823407364059 NLYIISVK(ub)GIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLYIISVKGIK 11 1 P62829;C9JD32;J3KT29;B9ZVP7 P62829 RPL23 60S ribosomal protein L23 1 12655100.0 3324800.0 4124100.0 5206200.0 True False 2764718.513613927 4101882.654730247 6294792.349250971 1.0 1.483652905180728 2.276829383625994 21.398701171055116 -6.963732610950676 0.379180704121975 0.945012037051295 2.843482308851712 0.9998845805235244 0.005654692906941267 0.07839377890483608 0.016393232866949315 0.01033128935685604 0.06704908719279942 1.0870947266635075e-07 6.963732610950676 1.898470271800417 NLYVTFPIPDLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NLYVTFPIPDLQK 13 0 A0A3B3ISG5;P14735 A0A3B3ISG5 IDE Insulin-degrading enzyme 0 2952870.0 943400.0 1340200.0 669270.0 False True 1236806.535898595 1140247.3840586825 600020.3604911638 1.0 0.9219286533202561 0.4851367963181261 20.238188417635193 -6.937332306091255 0.6839292123197807 1.0052022079677077 0.37605012885687294 0.9977932219119172 0.010642978830738793 0.08900496376976134 0.06031106475272878 0.01016161512922884 0.03805666976301542 1.155227966171181e-07 6.937332306091255 -0.6291520791108347 down NLYVTFPIPDLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NLYVTFPIPDLQK 13 0 A0A3B3ISG5;P14735 A0A3B3ISG5 IDE Insulin-degrading enzyme 0 6092300.0 1909500.0 1857100.0 2325700.0 False True 1848883.9677074566 2598649.7146485597 1716529.4004955401 1.0 1.4055234184710808 0.9284138055585874 20.818223256226506 -6.681544953878464 1.8965853425649042 1.2562254227780234 0.9302155241756754 0.3311365383864665 0.1718130516300172 0.43509398951501094 3.0272378501182757 0.07265873895736898 0.19124097602056503 2.0818768987174441e-07 6.681544953878464 -0.32600989860234797 NLYVTFPIPDLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NLYVTFPIPDLQK 13 0 A0A3B3ISG5;P14735 A0A3B3ISG5 IDE Insulin-degrading enzyme 0 5235730.0 943400.0 951230.0 3341100.0 False True 1292200.4744263885 909201.5133030408 2552000.9921144443 1.0 0.7036071656811904 1.974926524653448 20.301398479158085 -6.845293502627355 1.2575508640230393 0.8422589681822539 2.0213280012108545 0.9331809491326195 0.14038706011501045 0.16270765357022166 0.4975229183423702 0.08744983669473821 0.20185180341476983 1.427928617095482e-07 6.845293502627355 1.1790690330286007 NLYVTFPIPDLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NLYVTFPIPDLQK 13 0 A0A3B3ISG5;P14735 A0A3B3ISG5 IDE Insulin-degrading enzyme 0 5751800.0 1909500.0 2180400.0 1661900.0 False True 1587833.8551930347 2168653.7524244874 2009395.6062425931 1.0 1.3657938740453683 1.2654948750908883 20.598628531660783 -10.15525101294266 4.428163708653614 0.9999468359835955 1.3156443745779536 0.929602739494237 0.04094689496644557 2.3186247580934183e-05 4.423228812591983e-06 0.039653849477438434 0.013215553507781325 6.99437619135127e-11 10.15525101294266 0.3156975385943581 NMACVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NMACVQR 7 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 16429530.0 684730.0 9444700.0 6300100.0 False True 897687.6609347524 8035587.57515225 5648226.086826508 1.0 8.95142923852254 6.291972511847908 19.775854039221223 -9.46675990975594 9.394197677226732 0.9999682145420298 7.621700875185495 0.8920778121829276 1.0857186623826758 0.0 0.0 1.051242574448576 0.3504141914828586 3.41381584838029e-10 9.46675990975594 6.621732660643466 NMACVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NMACVQR 7 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 6260500.0 3226900.0 1016600.0 2017000.0 False True 3124463.825815756 1422533.681498965 1488687.1912970305 1.0 0.45528889460820066 0.4764616504748152 21.57517720639354 -10.147143185295132 4.966085350532458 1.0000310658292322 0.46587527254013966 0.9988228837564636 0.008643741391693216 2.9732177220145536e-06 5.106004262173639e-07 0.00836975229024865 0.0027897555375686355 7.126180438406189e-11 10.147143185295132 -0.5341557932890926 NMACVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NMACVQR 7 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 14363730.0 684730.0 8020900.0 5658100.0 False True 937893.1851324799 7666510.116430669 4321773.312227333 1.0 8.174182559336705 4.6079589666885905 19.839064100744114 -9.19911096218412 10.042793290155206 1.000000010978551 6.3910707824803055 0.75290304663596 1.4559046851124846 0.0 4.173708064813956e-17 1.4096736707813766 0.46989121659186733 6.322502908699712e-10 9.19911096218412 5.391070771501754 NMAQFSVLLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NMAQFSVLLPR 11 0 B4DUC8;Q13126 B4DUC8 MTAP S-methyl-5-thioadenosine phosphorylase 0 18135700.0 6249200.0 6239800.0 5646700.0 False True 8192761.717338891 5308846.162549905 5062433.650971143 1.0 0.6479922577650998 0.6179154021112533 22.965918424644972 -13.999999999999998 0.3483846320566876 5.286024211711743 0.6136707504151601 0.9997516187195847 0.002733780926230838 20.500478959333833 0.18989365288940943 64.97426178823635 0.009023792623557427 1.0000000000000041e-14 13.999999999999998 -4.6723534612965825 NMAQFSVLLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NMAQFSVLLPR 11 0 B4DUC8;Q13126 B4DUC8 MTAP S-methyl-5-thioadenosine phosphorylase 0 14726600.0 6429300.0 2498000.0 5799300.0 False True 6225205.390720888 3495464.426897909 4280289.354729243 1.0 0.5615018633936396 0.6875739973349825 22.569690006711507 -10.48492710862306 9.168218432295383 1.0000071164809816 0.6245379303643145 0.9220325070082086 0.05146873315668438 7.4868988061069095e-06 4.2070984943660477e-07 0.04983533005016909 0.016611462197186014 3.273956398929369e-11 10.48492710862306 -0.37546918611666713 NMAQFSVLLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NMAQFSVLLPR 11 0 B4DUC8;Q13126 B4DUC8 MTAP S-methyl-5-thioadenosine phosphorylase 0 16796500.0 3347200.0 7050400.0 6398900.0 False True 5077947.113098019 5792201.034973366 5134154.610262496 1.0 1.1406580072551378 1.011068941033178 22.275813938695464 -10.813671577874686 3.105730215898556 0.9799857684773304 1.0758634741649125 0.3136340427296488 0.05290451481966355 39428267.66356697 48458.868307664074 5642875.67121723 0.0181106226786381 1.5357779295953565e-11 10.813671577874686 0.09587770568758203 NMAQFSVLLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NMAQFSVLLPR 11 0 B4DUC8;Q13126 B4DUC8 MTAP S-methyl-5-thioadenosine phosphorylase 0 21660700.0 6249200.0 6354400.0 9057100.0 False True 8559698.118280048 6073641.596809228 6917999.516829712 1.0 0.7095625935496942 0.8082060162911199 23.029128486167863 -10.800260317437836 10.148754547473693 1.002265251722729 0.758884304920407 0.8884705379870435 0.04027100869969118 0.0020776448645005814 4.0890421227497554e-05 0.03924872959226091 0.01299741216907316 1.5839434873012842e-11 10.800260317437836 -0.24338094680232203 NMAQFSVLLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NMAQFSVLLPR 11 0 B4DUC8;Q13126 B4DUC8 MTAP S-methyl-5-thioadenosine phosphorylase 0 12296300.0 6429300.0 2413300.0 3453700.0 False True 5346247.816283093 2400299.073897456 4175852.701895439 1.0 0.4489689135970939 0.7810810208193164 22.350095282145784 -10.312703777548139 6.176739274280892 1.000021886836537 0.6150249672082156 0.6417789938810936 0.13558420001582433 4.086746031714529e-05 4.547456985525395e-06 0.13128628750320176 0.043759612389178436 4.867390862258081e-11 10.312703777548139 -0.3849969196283213 NMAQFSVLLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NMAQFSVLLPR 11 0 B4DUC8;Q13126 B4DUC8 MTAP S-methyl-5-thioadenosine phosphorylase 0 14446900.0 3347200.0 6758400.0 4341300.0 False True 4333016.383176078 6382289.098888931 3551227.9454996563 1.0 1.4729436804507872 0.8195740868389297 22.046940260787913 -6.712529840582366 1.7861890355837 1.2899999778472802 0.820991553147597 0.4771162434708417 0.19921872578519736 0.37000922609557446 2.3027172789482986 0.08870537064524074 0.22466454572937186 1.9385194347750102e-07 6.712529840582366 -0.4690084246996832 NMDPLNDNIATLLHQSSDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NMDPLNDNIATLLHQSSDK 19 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 19691900.0 6883200.0 2169700.0 10639000.0 False True 6664696.583673197 3036072.5248360247 7852326.736841417 1.0 0.4555454980911849 1.1781971824610307 22.66810776613969 -6.7051131416591 1.812346263579346 0.6636343802165258 1.1762890385128357 0.44203997599740563 0.22961199291593232 0.3849610751674068 2.4615676708577543 0.10093443513492856 0.25797871156111735 1.9719089508295526e-07 6.7051131416591 0.51265465829631 NMDSMPELQK(ub)LQQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NMDSMPELQKLQQLK 15 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 1 18121500.0 8714100.0 5683300.0 3724100.0 True False 11424269.48746444 4835373.793329888 3338765.8560896805 1.0 0.4232545283210993 0.292252021869164 23.445598580872815 -13.999999999999948 0.20825659584226383 4.311855563257284 0.21377484643468472 0.9994891069926518 0.006949168818313477 12.70644029551652 0.14465614958101566 17.204667671277715 0.07855819717054612 1.0000000000001186e-14 13.999999999999948 -4.098080716822599 NMEK(ub)IQVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NMEKIQVIK 9 1 B1AK44;Q9UI95;B1AK45;B1AK43 B1AK44 MAD2L2 Mitotic spindle assembly checkpoint protein MAD2B 1 11453400.0 1144100.0 2787600.0 7521700.0 True False 1735683.34491379 2290131.000381791 6035032.698121768 1.0 1.3194405575721764 3.477035552485251 20.727072338309178 -6.933384608156658 0.7184743573841335 0.9709507742192915 3.9607285206837677 0.9971625096123102 0.05860288113536681 0.09091826450741443 0.06934916713585712 0.05450844853021979 0.19172190495968455 1.1657767560369895e-07 6.933384608156658 2.989777746464476 up NMEK(ub)IQVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NMEKIQVIK 9 1 B1AK44;Q9UI95;B1AK45;B1AK43 B1AK44 MAD2L2 Mitotic spindle assembly checkpoint protein MAD2B 1 2870220.0 778560.0 845060.0 1246600.0 True False 647407.1360560823 840507.4940487231 1507258.2963728341 1.0 1.2982672683668308 2.3281459416015244 19.304313742201973 -6.948254854268608 0.577683926327439 0.9875796426098764 2.6895708537454177 0.999057129834366 0.0174710304790455 0.08419414366664964 0.03892136736881832 0.018351268722392414 0.08597801420370485 1.126536184105541e-07 6.948254854268608 1.7019912111355413 up NMEK(ub)IQVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NMEKIQVIK 9 1 B1AK44;Q9UI95;B1AK45;B1AK43 B1AK44 MAD2L2 Mitotic spindle assembly checkpoint protein MAD2B 1 13677200.0 1144100.0 3681200.0 8851900.0 True False 1481060.00358262 3476337.98396513 7240945.028164013 1.0 2.3471959107369176 4.889028810884421 20.498198660401627 -6.961168657687343 0.4186387434788724 0.8859863647933872 6.445908842466394 0.9998111148400758 0.022160995057652795 0.07928627756522769 0.019608195506003474 0.032853395651000546 0.21166879556546547 1.0935316122465613e-07 6.961168657687343 5.559922477673006 NMFEK(ub)IHQETFGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NMFEKIHQETFGK 13 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 14985100.0 2028300.0 4387300.0 8569500.0 True False 2659120.942085139 3732731.941561455 7682810.344448478 1.0 1.4037465850028048 2.8892293775942486 21.342517964638784 -6.946796800135886 0.5929683797550865 0.9829751233103834 3.38513042609439 0.9989253371175354 0.026629703623676587 0.0847980574891644 0.04148622053064878 0.027524225478618446 0.12455860434133477 1.130324652894176e-07 6.946796800135886 2.402155302784007 up NMFEK(ub)IHQETFGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NMFEKIHQETFGK 13 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 18772200.0 3380800.0 3405400.0 11986000.0 True False 3273478.3545563594 4765193.978926398 8846507.027707592 1.0 1.455697415042845 2.7024791581084155 21.64239300865157 -6.953501267147214 0.5189844227404596 0.9786464313515613 3.2350733051008835 0.9994481778979214 0.01690430513693183 0.08210953624644655 0.030374038829836768 0.019181520615347128 0.10297470979681883 1.1130091453543709e-07 6.953501267147214 2.256426873749322 up NMFEK(ub)IHQETFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NMFEKIHQETFGK 13 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 78773000.0 8724000.0 29571000.0 40478000.0 True False 13234945.80983124 24293824.010722473 32477505.55786231 1.0 1.8355816759503791 2.4539205543053475 23.657848951976636 -7.38729642516868 0.1339908605412206 1.0583366273191618e-13 4.050092318886379 0.9999943318378537 0.0014183800256456758 0.12309030887358573 0.00967034261401566 0.1016708465703725 0.17579090477340722 4.0992421609417e-08 7.38729642516868 4.050092318886273 NMFEK(ub)IHQETFGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NMFEKIHQETFGK 13 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 14879100.0 2028300.0 3526300.0 9324500.0 True False 2778217.3227464953 3370496.406085292 7122245.144105577 1.0 1.2131867361453497 2.5636025971735914 21.405728026161675 -6.934698658364204 0.7071666972036786 0.9826017870927114 2.8772050211087694 0.9973837234896603 0.035412520489501005 0.09027046354464663 0.06626053705396788 0.033217247465554885 0.1191909168350985 1.1622547817556834e-07 6.934698658364204 1.8946032340160581 up NMFEK(ub)IHQETFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NMFEKIHQETFGK 13 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 21210600.0 3380800.0 7126800.0 10703000.0 True False 2811284.9948345697 7088406.513840951 12940947.814919341 1.0 2.5214115704615954 4.603214486861675 21.422798284085847 -6.966738980708641 0.326834969127369 0.7368254590430671 6.455630390575286 0.9999446334264962 0.010989603648515058 0.07737571144836451 0.012805327865170094 0.03072887663186023 0.1820502198650012 1.0795953847591176e-07 6.966738980708641 5.718804931532219 NMFEK(ub)IHQETFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NMFEKIHQETFGK 13 1 Q15393;Q15393-2;J3QL37 Q15393 SF3B3 Splicing factor 3B subunit 3 1 71370000.0 8724000.0 22453000.0 40193000.0 True False 11293389.975749316 21203470.812226716 32878286.415006496 1.0 1.8775116114610102 2.911285848235753 23.428975274069085 -6.968960748888091 0.28190437850722105 0.7774136974499579 4.042967367251315 0.9999731038619086 0.00405114540954843 0.07664136659300388 0.010231728805283552 0.018887980923049514 0.09466154313100901 1.0740864828438721e-07 6.968960748888091 3.2655536698013568 NMGGPYGGGNYGPGGSGGSGGYGGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 NMGGPYGGGNYGPGGSGGSGGYGGR 25 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 114811900.0 14359400.0 65817800.0 34634700.0 False True 18825312.456627402 55998040.795775026 31051033.48350186 1.0 2.9746141491564493 1.6494299127858791 24.166170474706927 -10.162872567096239 5.657094264998992 0.9999836060593871 2.312022030377649 0.5665326026998849 0.5410041990666068 0.00016452633618281449 2.4344525967948583e-05 0.5238346349825301 0.17460835443162842 6.872700727236846e-11 10.162872567096239 1.3120384243182621 NMGGPYGGGNYGPGGSGGSGGYGGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 NMGGPYGGGNYGPGGSGGSGGYGGR 25 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 89430200.0 28256200.0 11694400.0 49479600.0 False True 27359222.397661917 16364034.90549035 36519408.40381788 1.0 0.5981176901756097 1.334811635835775 24.705523890817684 -6.758523532175252 1.6176714513187254 0.766149148649852 1.3373466379942964 0.6851153471363114 0.16899986501969141 0.28537009625064713 1.4714185558965043 0.08243663114030791 0.19842626531365493 1.7437188717850222e-07 6.758523532175252 0.5711974893444445 NMGGPYGGGNYGPGGSGGSGGYGGR ddPTM_RPMI8226_Bortezomib_8h_R1 2 NMGGPYGGGNYGPGGSGGSGGYGGR 25 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 322010000.0 14124400.0 296771900.0 11113700.0 False True 21427747.431955528 243810635.7555622 8917072.323692258 1.0 11.378267199097357 0.41614604390912746 24.352976860490337 -6.658623879242208 1.9783124027921133 7.6884024927809875 0.4627697753379786 0.2294228475625456 4.42039624092755 0.48781551173003945 3.668820908535862 1.80637064708514 4.89782453924963 2.1947048367605786e-07 6.658623879242208 -7.225632717443009 NMGGPYGGGNYGPGGSGGSGGYGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NMGGPYGGGNYGPGGSGGSGGYGGR 25 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 106176260.0 14359400.0 46522960.0 45293900.0 False True 19668458.228194073 44467421.796344474 34596413.67715194 1.0 2.2608493904520652 1.7589794418943905 24.22938053622982 -10.417458684710393 5.469062584350142 0.9993418428337765 2.009914416173234 0.8437292767274464 0.20488754853388244 0.0016451768225561353 0.0001752372158443509 0.1984970144589279 0.06612717194307895 3.8242063235580654e-11 10.417458684710393 1.0105725733394575 NMGGPYGGGNYGPGGSGGSGGYGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NMGGPYGGGNYGPGGSGGSGGYGGR 25 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 31702900.0 22154000.0 6344000.0 3204900.0 False True 18422032.588607714 6309823.6128145885 3875029.772216667 1.0 0.3425150608362629 0.21034756906319918 24.134928913682348 -13.999999999999948 0.22553899026179555 5.0666464119192725 0.14329687150466652 0.999504037001974 0.007690684043455428 13.156259316766246 0.15040411145660337 23.899763175022073 0.07056255730114362 1.0000000000001186e-14 13.999999999999948 -4.9233495404146055 NMGGPYGGGNYGPGGSGGSGGYGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NMGGPYGGGNYGPGGSGGSGGYGGR 25 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 64458800.0 14124400.0 16260900.0 34073500.0 False True 18284314.233548068 15355966.6205201 27872472.623634074 1.0 0.8398437274910189 1.5243925622593846 24.124103182582786 -6.845060299145829 1.2586566810121944 0.9147705608217115 1.5492640836411955 0.9328122928441601 0.07578022846164356 0.1629718988974369 0.4993177965328238 0.047165828214189257 0.10885672599636702 1.4286955790529832e-07 6.845060299145829 0.634493522819484 NMLQFNLQILPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NMLQFNLQILPK 12 0 O15371-2;O15371-3;O15371;B0QYA5;B0QYA6 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 0 7259900.0 3695500.0 2221900.0 1342500.0 False True 4844836.287272902 1890401.1808983672 1203590.9781693304 1.0 0.3901888668280369 0.24842758491780054 22.208016485422736 -13.999999999999691 0.20497713008939342 4.455983261076145 0.1607482456280585 0.9994878151667261 0.0073791896909738254 12.633755426341727 0.1435329854658101 17.543005256020543 0.08702780537191701 1.0000000000007117e-14 13.999999999999691 -4.295235015448087 NMLQFNLQILPK ddPTM_RPMI8226_Bortezomib_2h_R1 2 NMLQFNLQILPK 12 0 O15371-2;O15371-3;O15371;B0QYA5;B0QYA6 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 0 78517800.0 45711500.0 14524700.0 18281600.0 False True 44260413.45371003 20324488.455309898 13493100.523755984 1.0 0.45920240841325094 0.3048570826810692 25.399513592188036 -13.999999999999998 0.17585148994423658 3.7715439454625996 0.176854562169538 0.9995037329905377 0.0066396890716211915 12.153864347062893 0.13289026884668506 11.49972767016655 0.11943506961392962 1.0000000000000041e-14 13.999999999999998 -3.5946893832930615 NMLQFNLQILPK ddPTM_RPMI8226_Bortezomib_8h_R1 2 NMLQFNLQILPK 12 0 O15371-2;O15371-3;O15371;B0QYA5;B0QYA6 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 0 871515000.0 296649500.0 298589500.0 276276000.0 False True 450038979.48344016 245303870.83458835 221669927.50392726 1.0 0.5450724982003802 0.49255717306612534 28.745474722923447 -13.999999999999998 0.30470533378615067 5.263959991704728 0.48025494278385467 0.9996603009479255 0.004199368092673844 16.90151465516414 0.17545304620738308 45.55728620602914 0.018602830721965228 1.0000000000000041e-14 13.999999999999998 -4.783705048920873 NMLQFNLQILPK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NMLQFNLQILPK 12 0 O15371-2;O15371-3;O15371;B0QYA5;B0QYA6 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 0 23369100.0 4871800.0 7603000.0 10894300.0 False True 6673036.115444643 7267074.320241172 8321290.715151407 1.0 1.0890206788213892 1.2470021997770853 22.669911881272196 -6.9623143306277715 0.4015009810145233 0.9914580227780593 1.350347246834421 0.9998466087734118 0.0012650011673427724 0.07888469352843651 0.01815211040856041 0.0020324558952108116 0.013228909079776951 1.0906506671878445e-07 6.9623143306277715 0.3588892240563618 NMLQFNLQILPK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NMLQFNLQILPK 12 0 O15371-2;O15371-3;O15371;B0QYA5;B0QYA6 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 0 84300400.0 45711500.0 12379400.0 26209500.0 False True 38011137.612807706 12312709.715081498 31689785.270964112 1.0 0.32392373626125776 0.8336973650661369 25.179918867622312 -9.994167818555512 6.769543997742165 1.0000000653811059 0.5788105506639502 0.4764958383368715 0.20811421248315723 2.0550248835225242e-07 3.01617903774258e-08 0.2015057497905635 0.06716857325469419 1.0135196693310996e-10 9.994167818555512 -0.4211895147171557 NMLQFNLQILPK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NMLQFNLQILPK 12 0 O15371-2;O15371-3;O15371;B0QYA5;B0QYA6 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 0 666734100.0 296649500.0 201894800.0 168189800.0 False True 384018625.5858605 190659176.90020734 137580982.17308113 1.0 0.49648419164392577 0.3582664303409424 28.516601045015896 -13.999999999999995 0.18140195335280962 3.623859315765729 0.2500474788859939 0.9994965144016805 0.0061879145607565186 12.223181816915433 0.13502910031122312 11.307932004870917 0.10198172362074615 1.0000000000000123e-14 13.999999999999995 -3.373811836879735 NMMAACDPR ddPTM_RPMI8226_Bortezomib_1h_R1 2 NMMAACDPR 9 0 A0A0B4J269;Q13509;Q13509-2;P04350;A6NNZ2;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q3ZCM7;A0A075B736;Q5SQY0;Q9BUF5;K7ESM5;Q9BVA1 A0A0B4J269;P04350;P07437;P68371;Q13885;Q3ZCM7;Q9BUF5;Q9BVA1 TUBB3;TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB8;TUBB6;TUBB2B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-8 chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 42227690.0 1474690.0 25816500.0 14936500.0 False True 1933332.870918274 21964778.831928793 13391014.261025108 1.0 11.361095216622576 6.926388343392096 20.882658623779093 -9.645329065933698 12.461250244141604 0.9997823117861476 9.143741780007336 0.81805997190634 1.8104615040671248 0.0 0.0 1.7529718115792423 0.5843239371930806 2.2629290312783195e-10 9.645329065933698 8.143959468221189 NMMAACDPR ddPTM_RPMI8226_Bortezomib_2h_R1 2 NMMAACDPR 9 0 A0A0B4J269;Q13509;Q13509-2;P04350;A6NNZ2;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q3ZCM7;A0A075B736;Q5SQY0;Q9BUF5;K7ESM5;Q9BVA1 A0A0B4J269;P04350;P07437;P68371;Q13885;Q3ZCM7;Q9BUF5;Q9BVA1 TUBB3;TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB8;TUBB6;TUBB2B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-8 chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 15470650.0 7491700.0 2466250.0 5512700.0 False True 7253880.084249259 3451036.4863238493 4068758.4925449397 1.0 0.4757504185680255 0.5609078789956363 22.790321465268033 -10.772035150617668 7.0833058573179315 1.0116951450475984 0.5183291487818309 0.9770943588085383 0.034765387639816174 0.0063457986106647225 0.00020422913175370837 0.03326813433354505 0.011220480612787758 1.690304117475064e-11 10.772035150617668 -0.4933659962657675 NMMAACDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NMMAACDPR 9 0 A0A0B4J269;Q13509;Q13509-2;P04350;A6NNZ2;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q3ZCM7;A0A075B736;Q5SQY0;Q9BUF5;K7ESM5;Q9BVA1 A0A0B4J269;P04350;P07437;P68371;Q13885;Q3ZCM7;Q9BUF5;Q9BVA1 TUBB3;TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB8;TUBB6;TUBB2B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-8 chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 31945010.0 900620.0 30490000.0 554390.0 False True 1366306.3841414726 25048821.280542664 444814.5735022305 1.0 18.333238848387765 0.32555990271664625 20.381849602965403 -6.530074097152014 2.4739920320829563 9.999999999999998 0.3281185257980289 0.2769112300006652 7.0871969272770015 0.5519658149674432 6.314564224377945 2.7531597221422515 8.91418761773715 2.9507057490627155e-07 6.530074097152014 -9.67188147420197 NMMAACDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NMMAACDPR 9 0 A0A0B4J269;Q13509;Q13509-2;P04350;A6NNZ2;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q3ZCM7;A0A075B736;Q5SQY0;Q9BUF5;K7ESM5;Q9BVA1 A0A0B4J269;P04350;P07437;P68371;Q13885;Q3ZCM7;Q9BUF5;Q9BVA1 TUBB3;TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB8;TUBB6;TUBB2B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-8 chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 40587490.0 1474690.0 21809600.0 17303200.0 False True 2019922.7449987824 20845979.757297378 13216540.530590124 1.0 10.320186655113854 6.543092087711548 20.945868685301985 -10.446637374102224 11.845726209713517 0.999997929375243 8.4316393714127 0.8377069741133575 1.5419924000623357 8.432629838909812e-05 3.951593705748724e-06 1.4930281615388201 0.4976759071183195 3.5757127732728894e-11 10.446637374102224 7.431641442037457 NMMAACDPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NMMAACDPR 9 0 A0A0B4J269;Q13509;Q13509-2;P04350;A6NNZ2;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q3ZCM7;A0A075B736;Q5SQY0;Q9BUF5;K7ESM5;Q9BVA1 A0A0B4J269;P04350;P07437;P68371;Q13885;Q3ZCM7;Q9BUF5;Q9BVA1 TUBB3;TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB8;TUBB6;TUBB2B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-8 chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 5627700.0 1354300.0 1763200.0 2510200.0 False True 1753168.0472440706 1665076.3700226326 2053369.356827042 1.0 0.9497528617636424 1.1712336190788324 20.741532859378204 -6.847073276871624 1.249047921948308 0.9732379539427762 1.1796039923284494 0.935947374430643 0.02399495802393598 0.16070746126498953 0.48393857205924706 0.015042524131586193 0.03475212647008178 1.4220888231902034e-07 6.847073276871624 0.20636603838567313 NMQFSNTPDSGVSLLHKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 NMQFSNTPDSGVSLLHKK 18 1 E7EPJ2;A0A087WVF7;Q9NZM3-4;Q9NZM3-3;Q9NZM3-2;Q9NZM3 E7EPJ2 ITSN2 Intersectin-2 1 20497000.0 0.0 10186000.0 10311000.0 True False 0.0 8666288.504717022 9244116.63009605 0.0 NMQFSNTPDSGVSLLHKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 NMQFSNTPDSGVSLLHKK 18 1 E7EPJ2;A0A087WVF7;Q9NZM3-4;Q9NZM3-3;Q9NZM3-2;Q9NZM3 E7EPJ2 ITSN2 Intersectin-2 1 27339000.0 11621000.0 15718000.0 0.0 True False 11252097.716013784 21994279.368287165 0.0 1.0 1.9546825777192907 0.0 23.42369065075357 -6.780648256863025 1.5777176577069003 1.5444842238072831 1.3811678243551677e-19 0.7449650323956039 0.40303186476666997 0.2554736372273698 1.2631825153305951 0.20263434309824013 0.46924316979579256 1.6571115454135977e-07 6.780648256863025 -1.5444842238072831 NMQFSNTPDSGVSLLHKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NMQFSNTPDSGVSLLHKK 18 1 E7EPJ2;A0A087WVF7;Q9NZM3-4;Q9NZM3-3;Q9NZM3-2;Q9NZM3 E7EPJ2 ITSN2 Intersectin-2 1 19245400.0 0.0 11924000.0 7321400.0 True False 0.0 11397158.252604978 5592236.1089661205 0.0 NMQFSNTPDSGVSLLHKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NMQFSNTPDSGVSLLHKK 18 1 E7EPJ2;A0A087WVF7;Q9NZM3-4;Q9NZM3-3;Q9NZM3-2;Q9NZM3 E7EPJ2 ITSN2 Intersectin-2 1 31570000.0 11621000.0 19949000.0 0.0 True False 9663376.397590065 19841530.77743355 0.0 1.0 2.0532710267171006 0.0 23.204095926187847 -6.7725518977004695 1.5994133111494429 1.6059580184789997 6.28197110131777e-10 0.7197801589903463 0.44378110904115126 0.26703648451213585 1.3541204619109815 0.2199172743684237 0.5149972951122129 1.6882940981924403e-07 6.7725518977004695 -1.6059580178508026 NMQITILTCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NMQITILTCR 10 0 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 0 18139800.0 4975000.0 7276900.0 5887900.0 False True 6522273.177968538 6191214.885134034 5278676.58872491 1.0 0.94924188487646 0.8093308030328522 22.636943437311334 -6.953337155604019 0.5209198098745899 1.0023606683855733 0.7499584388126108 0.9994378181245805 0.0019116847645930762 0.08217272889790891 0.030625799565015828 0.00216253697373047 0.011557792628151849 1.113429809608242e-07 6.953337155604019 -0.25240222957296243 NMQITILTCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NMQITILTCR 10 0 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 0 20963000.0 4975000.0 6148000.0 9840000.0 False True 6814391.944319792 5876361.031282748 7515994.661161342 1.0 0.8623456178186303 1.102958961353313 22.700153498834226 -6.751533516052704 1.6440518787459284 0.9192071230619069 1.1034968728713137 0.6555746281091472 0.057848414855188074 0.297386551135128 1.581930108766076 0.027789684746063855 0.06736070435731024 1.7720112874328297e-07 6.751533516052704 0.18428974980940682 NMSGSLYEMVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NMSGSLYEMVSR 12 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 9578700.0 1967000.0 2865300.0 4746400.0 False True 2578756.048455093 2437808.408851924 4255288.058683727 1.0 0.9453427788613004 1.6501320709390201 21.298243869271488 -6.888170899683756 1.0331668728118615 0.960453515088381 1.7086164661820127 0.9797005880040106 0.04561178553032379 0.12063873782364667 0.23062940370560056 0.03371682222127814 0.08351979239885014 1.293686661257707e-07 6.888170899683756 0.7481629510936317 NMSGSLYEMVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NMSGSLYEMVSR 12 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 5756100.0 2142200.0 0.0 3613900.0 False True 2074197.0335809973 0.0 2667311.175323921 1.0 0.0 1.285948794709701 20.98412151548519 -6.699195066601748 1.8340121724401235 0.3785281549975947 1.2820272283874972 0.4135806439822276 0.4221781738922571 0.3972280170864615 2.5971043102507054 0.18369393780811966 0.472834549434054 1.9989638184746587e-07 6.699195066601748 0.9034990733899024 NMSGSLYEMVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NMSGSLYEMVSR 12 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 8324700.0 1967000.0 3439600.0 2918100.0 False True 2694253.056176282 3287627.0987638505 2228904.880155983 1.0 1.2202369377395057 0.8272811921086852 21.36145393079438 -6.754594796729795 1.6325909547522055 1.128780208350253 0.8262055685070707 0.6686123516498865 0.09257464183587849 0.2920918742333571 1.5330114977428388 0.044766458948932546 0.10817246969179187 1.7595645484654815e-07 6.754594796729795 -0.3025746398431822 NMSGSLYEMVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NMSGSLYEMVSR 12 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 3588800.0 2142200.0 0.0 1446600.0 False True 1781334.2155509398 0.0 1749077.3716773158 1.0 0.0 0.9818917508056468 20.764526790919465 -11.95438509561659 13.998363687012144 0.8647220786069016 0.5418512878625575 0.0 0.48205762782011335 0.0 0.0 0.0 0.1376636564692404 1.1107463745375844e-12 11.95438509561659 -0.3228707907443441 NMSVHLSPCFR ddPTM_RPMI8226_Bortezomib_1h_R1 2 NMSVHLSPCFR 11 0 P62280;M0QZC5;M0R1H5 P62280 RPS11 40S ribosomal protein S11 0 326647300.0 121248900.0 127910400.0 77488000.0 False True 158958482.0760177 108826666.91083407 69470285.07738177 1.0 0.684623214121978 0.43703414986159367 27.244074760302784 -7.457179442980064 0.17753032997079127 1.2348036125133661 1.6983339536949325e-14 0.9999746754747705 0.0011593608788678653 0.1265030023686807 0.01494097482467478 0.031896764250372286 0.062330946019031185 3.4899608652806376e-08 7.457179442980064 -1.2348036125133492 down NMSVHLSPCFR ddPTM_RPMI8226_Bortezomib_2h_R1 2 NMSVHLSPCFR 11 0 P62280;M0QZC5;M0R1H5 P62280 RPS11 40S ribosomal protein S11 0 82852000.0 56853400.0 14340000.0 11658600.0 False True 55048619.93697771 20066036.782112077 8604862.90949707 1.0 0.3645148017349869 0.15631387161655147 25.714203060243953 -11.789361858635255 0.19491193762083708 2.424454052738626 3.2113767070523815e-23 0.9994058578722905 0.008747111663550081 4.780414022625352 0.12119096903083411 2.9340070813415218 0.13503861504625472 1.6241948958884793e-12 11.789361858635255 -2.424454052738626 NMSVHLSPCFR ddPTM_RPMI8226_Bortezomib_8h_R1 2 NMSVHLSPCFR 11 0 P62280;M0QZC5;M0R1H5 P62280 RPS11 40S ribosomal protein S11 0 174814500.0 77897500.0 47485200.0 49431800.0 False True 118176202.57007438 39011095.056439005 39661583.06327236 1.0 0.33010956696892324 0.3356139578080825 26.81636430484522 -9.98783180197318 5.760130278261339 1.0000009862684298 0.33286176238823006 0.9999489461124265 0.002247158151097701 2.8460676816065223e-08 5.003917315232222e-09 0.002175804732844357 0.0007252671744837837 1.0284145159433113e-10 9.98783180197318 -0.6671392238801997 NMSVHLSPCFR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NMSVHLSPCFR 11 0 P62280;M0QZC5;M0R1H5 P62280 RPS11 40S ribosomal protein S11 0 270405200.0 121248900.0 65967300.0 83189000.0 False True 166077894.9583185 63052646.56131078 63541471.53123481 1.0 0.3796570674088533 0.38260041498708885 27.307284821825675 -10.640469915119308 10.088850041629609 1.0001460007887926 0.38112874119798196 0.9999830352917555 0.0012016166170556169 3.946957168835367e-06 1.4065404372039925e-07 0.0011637213717079166 0.0003878200955318719 2.2883902297357975e-11 10.640469915119308 -0.6190172595908106 NMSVHLSPCFR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NMSVHLSPCFR 11 0 P62280;M0QZC5;M0R1H5 P62280 RPS11 40S ribosomal protein S11 0 88489840.0 56853400.0 8566140.0 23070300.0 False True 47276121.13266904 8519992.503574334 27894193.06498493 1.0 0.18021767225075486 0.5900271087534148 25.49460833567823 -9.816140145894343 9.90738735546877 1.000000396721805 0.38512238818908123 0.7500996871400019 0.16730400186832675 0.0 0.0 0.1619914032474002 0.05399713441580005 1.527073195486839e-10 9.816140145894343 -0.6148780085327237 NMSVHLSPCFR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NMSVHLSPCFR 11 0 P62280;M0QZC5;M0R1H5 P62280 RPS11 40S ribosomal protein S11 0 229798300.0 77897500.0 98727800.0 53173000.0 False True 100839849.33928615 93233511.14128897 43496059.601053365 1.0 0.9245701154074034 0.43133800661191346 26.58749062693767 -6.9340428174926245 0.7128245335435961 1.0064937185870046 0.31880022595712765 0.9972748917040721 0.013164342417237235 0.09059226390325359 0.06778981545359744 0.012296081117812298 0.04367947227900957 1.1640112628115457e-07 6.9340428174926245 -0.687693492629877 down NMSVIAHVDHGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 NMSVIAHVDHGK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 317142110.0 111505490.0 92950800.0 112685820.0 False True 146184777.21070102 79082902.95938061 101026172.30511206 1.0 0.5409790572474983 0.6910854483808506 27.12321784476629 -10.375815725655732 5.099401499872177 1.000251958213833 0.6160322528141399 0.8971646784597256 0.061280677568011345 0.0001756523769817052 2.150044759427084e-05 0.059373170319228105 0.019778253638750597 4.209051836671111e-11 10.375815725655732 -0.3842197053996931 NMSVIAHVDHGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 NMSVIAHVDHGK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 237223230.0 50915730.0 31778200.0 154529300.0 False True 49299438.0210115 44467400.981123805 114053440.55037 1.0 0.9019859610199152 2.3134835837633734 25.555067865197667 -6.890251616411891 1.0209121903716787 0.924615202481833 2.435476965178026 0.981058163826813 0.08856853595478471 0.11893846897162771 0.22066653248790855 0.06608142742886482 0.16488900674216075 1.2875033970402935e-07 6.890251616411891 1.5108617626961929 up NMSVIAHVDHGK ddPTM_RPMI8226_Bortezomib_8h_R1 2 NMSVIAHVDHGK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 484224800.0 105068900.0 236548000.0 142607900.0 False True 159397202.86549488 194334161.24204025 114421386.05773705 1.0 1.2191817531831248 0.7178381050656827 27.24805107194368 -6.787896940402748 1.5049073367941233 1.1228384568289942 0.7128246600198497 0.7943669158045352 0.09305627485049134 0.23851046408060564 1.0671740025975947 0.04867931246404682 0.11413834846080283 1.6296827161571562e-07 6.787896940402748 -0.4100137968091445 NMSVIAHVDHGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NMSVIAHVDHGK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 288590590.0 111505490.0 105808030.0 71277070.0 False True 152732082.97556373 101133081.37423496 54442894.0633357 1.0 0.6621600347741979 0.35646010322563504 27.186427906289182 -7.376861773669575 0.24124613730468983 1.133299788654738 1.4826299270031823e-16 0.9999290829901762 0.0022133701427848487 0.11593320935248123 0.018482011899532243 0.020234818635070637 0.054460615634852 4.198926052570763e-08 7.376861773669575 -1.1332997886547378 down NMSVIAHVDHGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NMSVIAHVDHGK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 149426630.0 50915730.0 66457800.0 32053100.0 False True 42338685.44428779 66099778.640559584 38755255.01321045 1.0 1.5612147129021827 0.9153627375655612 25.335473140631944 -6.677012433714434 1.912833853338899 1.356049775870599 0.9178975404696041 0.3102962345950868 0.23801578902677364 0.445232528203143 3.147096385698872 0.09994800668305535 0.2645872944009563 2.103718210113554e-07 6.677012433714434 -0.4381522354009948 NMSVIAHVDHGK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NMSVIAHVDHGK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 388475870.0 105068900.0 172698070.0 110708900.0 False True 136013762.26765326 163087270.59069574 90561016.16924115 1.0 1.1990497716677093 0.6658224481066232 27.01917739403613 -6.805579446709933 1.4327754185308335 1.1090591072591065 0.6573844158810916 0.8480542126708835 0.08575913353493327 0.21287846188928092 0.862043001583632 0.047073406855533385 0.10913751647769925 1.5646620650148043e-07 6.805579446709933 -0.45167469137801486 NNALNQVVLWDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNALNQVVLWDK 12 0 P61009 P61009 SPCS3 Signal peptidase complex subunit 3 0 5146900.0 1125900.0 0.0 4021000.0 False True 1476065.8032311092 0.0 3604945.492155586 1.0 0.0 2.442266113248039 20.49332560771373 -6.7955285697110215 1.474105857196718 0.44508985564867676 2.472369860105992 0.8187618441300619 0.4267788943340327 0.2272051590175197 0.97511080384886 0.22781454386013486 0.5313189899276433 1.601295304963704e-07 6.7955285697110215 2.027280004457315 NNALNQVVLWDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNALNQVVLWDK 12 0 P61009 P61009 SPCS3 Signal peptidase complex subunit 3 0 1125900.0 1125900.0 0.0 0.0 False True 1542175.656303446 0.0 0.0 1.0 0.0 0.0 20.55653566923662 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 NNASLSK(ub)SVGVSNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNASLSKSVGVSNR 14 1 I1E4Y6;Q6Y7W6-4;Q6Y7W6-5;Q6Y7W6;Q6Y7W6-3;C9JH18 I1E4Y6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 3217810.0 946340.0 1533600.0 737870.0 True False 1240660.9043695957 1304792.8579259787 661522.2905488297 1.0 1.0516917663243122 0.5332015284909475 20.24267742336329 -6.882373683786283 1.0665050910600513 1.0331619856468666 0.4947469233884746 0.9755488636079255 0.036463844476517404 0.12554676279085372 0.2597741242925527 0.026279207945757072 0.06394919560206862 1.3110713170306806e-07 6.882373683786283 -0.538415062258392 NNASTDYDLSDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNASTDYDLSDK 12 0 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 0 30541500.0 1418500.0 15748000.0 13375000.0 False True 1859667.2367735382 13398459.785223221 11991083.302059425 1.0 7.204761970463657 6.447972553876662 20.826613062267317 -9.339399662218266 8.736177904794125 1.0000108266741858 6.8263672621711216 0.9875044688925974 0.30895798563075016 0.0 0.0 0.29914727876812996 0.09971576107524113 4.5772047270674245e-10 9.339399662218266 5.826356435496936 NNASTDYDLSDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNASTDYDLSDK 12 0 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 0 32386500.0 8959300.0 2477200.0 20950000.0 False True 8674891.925572868 3466358.8784273416 15462566.513471883 1.0 0.39958525226219826 1.7824506225708134 23.048414353595902 -6.788717211459876 1.5016215855535464 0.6638686836690523 1.7966086907291205 0.7970913275313448 0.2550381980082816 0.2372691533999187 1.0569801043247011 0.13370019450651283 0.3132974530718368 1.6266075678524485e-07 6.788717211459876 1.1327400070600682 NNASTDYDLSDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NNASTDYDLSDK 12 0 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 0 112914300.0 1458300.0 110030000.0 1426000.0 False True 2212347.7160106436 90394286.8316861 1144150.474961996 1.0 40.85898711920708 0.5171657541361331 21.077146721958258 -3.9869655153349552 15.531833874207885 9.999999999999998 18.456565898174336 0.0 19.34942920224364 0.0 0.0 6.626790252271207 0.0 0.00010304679403413803 3.9869655153349552 8.456565898174338 NNASTDYDLSDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNASTDYDLSDK 12 0 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 0 24691500.0 1418500.0 11779000.0 11494000.0 False True 1942957.7835211267 11258564.832055865 8779353.926360609 1.0 5.794549386272574 4.518551046667735 20.889823123790208 -10.045478911498373 6.731672188273128 0.9999984453986218 5.156550216470162 0.9339860374623647 0.5209241407784322 1.2195442251358794e-05 1.7328036591073176e-06 0.5043828406121544 0.16812754348935202 9.005774919933642e-11 10.045478911498373 4.15655177107154 NNASTDYDLSDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NNASTDYDLSDK 12 0 P39023;G5E9G0;B5MCW2 P39023 RPL3 60S ribosomal protein L3 0 4218200.0 1458300.0 2759900.0 0.0 False True 1887798.097390554 2606309.138852918 0.0 1.0 1.3806079911064324 0.0 20.848273044050707 -6.862208358866646 1.3786741336221646 1.2006659511788278 6.756180243838941e-21 0.9111745779694228 0.17352588981256217 0.16349101880905925 0.6247759525066164 0.10155644675126284 0.21134137571096057 1.373382917219229e-07 6.862208358866646 -1.2006659511788278 down NNCPDK(ub)TSAAAGSSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNCPDKTSAAAGSSSR 16 1 Q9ULT8;A0A087X2H1;H0YJP0 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 8850000.0 2686800.0 3598100.0 2565100.0 True False 3522420.81900821 3061277.505283949 2299688.058176649 1.0 0.8690834123975842 0.6528714700318402 21.74813584567935 -6.963608946616313 0.3811770225245218 1.0146565280326096 0.499638292737094 0.9998815289839131 0.0015579179541753098 0.07843627599794571 0.016544539089451072 0.002810472847745452 0.01825946672180536 1.0874043184110087e-07 6.963608946616313 -0.5150182352955157 NNCPDK(ub)TSAAAGSSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNCPDKTSAAAGSSSR 16 1 Q9ULT8;A0A087X2H1;H0YJP0 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 4431040.0 2060500.0 1552900.0 817640.0 True False 1995090.5553606774 2172981.06826652 603475.5553257827 1.0 1.0891641296320422 0.3024802827642502 20.92802279988449 -6.878721760044419 1.0868669060659217 1.0543859004015026 0.2480692462531712 0.9726412810392331 0.05817595837327921 0.12877008993427663 0.27915904586736107 0.041277762559710315 0.09950700764677724 1.3221424214388525e-07 6.878721760044419 -0.8063166541483314 down NNCPDK(ub)TSAAAGSSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NNCPDKTSAAAGSSSR 16 1 Q9ULT8;A0A087X2H1;H0YJP0 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 7703500.0 0.0 3224200.0 4479300.0 True False 0.0 2648816.3192104227 3593964.3916530684 0.0 NNCPDK(ub)TSAAAGSSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNCPDKTSAAAGSSSR 16 1 Q9ULT8;A0A087X2H1;H0YJP0 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 8119200.0 2686800.0 3063300.0 2369100.0 True False 3680182.568039878 2927953.2770215417 1809567.3731460676 1.0 0.7956000070347095 0.491705870480733 21.81134590720224 -6.965404169782181 0.35104743303611985 1.0290160410328753 0.24801886162049352 0.9999212345235992 0.0018533654387781699 0.0778240799370112 0.014377901466932795 0.0041604410760176505 0.02610249094103378 1.0829186425948765e-07 6.965404169782181 -0.7809971794123818 down NNCPDK(ub)TSAAAGSSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NNCPDKTSAAAGSSSR 16 1 Q9ULT8;A0A087X2H1;H0YJP0 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 4785900.0 2060500.0 1149900.0 1575500.0 True False 1713397.045627257 1143705.2604627195 1904929.765711055 1.0 0.6675074311477062 1.1117853684717192 20.708428075318768 -6.70643556542965 1.8081933116290307 0.7948428633356257 1.1106216259079509 0.44797711734397794 0.1401922417731583 0.38231335832323277 2.434429167425518 0.06175541404782954 0.15755304073898213 1.9659136338458645e-07 6.70643556542965 0.3157787625723252 NNCPDK(ub)TSAAAGSSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NNCPDKTSAAAGSSSR 16 1 Q9ULT8;A0A087X2H1;H0YJP0 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 3720000.0 0.0 2330400.0 1389600.0 True False 0.0 2200711.1914137644 1136707.0585000634 0.0 NNCPFSADENYRPLAK(ub)TR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNCPFSADENYRPLAKTR 18 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 64546570.0 44581000.0 15313970.0 4651600.0 True False 58446122.72301816 13029185.36938752 4170297.0532979188 1.0 0.22292642800505505 0.0713528435934298 25.800603984711636 -13.999999999997053 0.23126090993779252 5.938919964766797 2.7447609869132837e-11 0.9995053319278709 0.00904716707854254 13.390146707523495 0.15293421459108728 30.387595286711097 0.077683183388476 1.0000000000067856e-14 13.999999999997053 -5.93891996473935 NNCPFSADENYRPLAK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNCPFSADENYRPLAKTR 18 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 68935100.0 54413000.0 8214100.0 6308000.0 True False 52685689.099170305 11494032.965965625 4655745.564056359 1.0 0.21816233520891032 0.0883683148813494 25.65090780312423 -13.999999999999993 0.2526761027598387 6.51150296585508 0.037492761315078844 0.9995477831445277 0.008562641980311904 14.105690876945891 0.159059265637524 39.52264332530668 0.05902109513286155 1.0000000000000164e-14 13.999999999999993 -6.474010204540001 NNCPFSADENYRPLAK(ub)TR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NNCPFSADENYRPLAKTR 18 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 104694000.0 57190000.0 33909000.0 13595000.0 True False 86761411.14904265 27857674.01777376 10907942.291099831 1.0 0.32108368972835855 0.1257234310350448 26.370550182426534 -12.196012670484537 0.20642459844255637 2.764937536782505 1.5127520020121834e-15 0.999388310149196 0.009266671313666954 5.820330912504692 0.13169751804767327 4.448849603208664 0.11718152795749796 6.367769427531399e-13 12.196012670484537 -2.7649375367825035 NNCPFSADENYRPLAK(ub)TR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNCPFSADENYRPLAKTR 18 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 94559700.0 44581000.0 41572600.0 8406100.0 True False 61063800.45622524 39735785.06979585 6420752.3090638565 1.0 0.6507257126631221 0.10514825905188617 25.863814046234527 -7.468078901938341 0.5376674955644803 1.0082497523434863 4.789246420208931e-23 0.9963575148517891 0.022224395495831193 0.11386686616459325 0.07601312972202173 0.023028238754728245 0.06809366659547501 3.40346350494142e-08 7.468078901938341 -1.0082497523434863 down NNCPFSADENYRPLAK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NNCPFSADENYRPLAKTR 18 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 70422800.0 54413000.0 12302000.0 3707800.0 True False 45246820.40461821 12235726.684244186 4483083.837069786 1.0 0.27042180146199446 0.0990806380863883 25.431313078558507 -13.904544185380304 0.2080235638411764 5.019107065036524 9.757876607081609e-19 0.9994660142207097 0.009026634765863508 12.40349633142344 0.1464679789206745 20.355435463352038 0.10241463142180941 1.245821480200268e-14 13.904544185380304 -5.019107065036524 NNEDISIIPPLFTVSVDHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNEDISIIPPLFTVSVDHR 19 0 P51571;A6NLM8 P51571 SSR4 Translocon-associated protein subunit delta 0 11905100.0 6171200.0 3959800.0 1774100.0 False True 8090502.961985813 3369013.2751795095 1590533.1503688695 1.0 0.41641580146614093 0.1965926170279126 22.94779796273436 -11.32088935685768 0.1825682970838199 2.143708001367912 4.268510454715046e-22 0.9994594066961398 0.007882228398005219 3.7587361234990415 0.10833802734407111 1.8924373580981366 0.1553162492334529 4.77650947020961e-12 11.32088935685768 -2.143708001367912 NNEDISIIPPLFTVSVDHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNEDISIIPPLFTVSVDHR 19 0 P51571;A6NLM8 P51571 SSR4 Translocon-associated protein subunit delta 0 35869300.0 12923000.0 8834300.0 14112000.0 False True 12512766.438692559 12361882.060265884 10415643.849074725 1.0 0.9879415651873671 0.832401363847645 23.576897453407707 -6.922380022631944 0.8068947395122638 1.0031466085730172 0.8058940717811278 0.9948164755453247 0.005495035514123699 0.09679192551404125 0.09851110508109094 0.0047951794992331515 0.014707217930944158 1.1956938001475521e-07 6.922380022631944 -0.19725253679188937 NNEDISIIPPLFTVSVDHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NNEDISIIPPLFTVSVDHR 19 0 P51571;A6NLM8 P51571 SSR4 Translocon-associated protein subunit delta 0 146144800.0 30390000.0 71062800.0 44692000.0 False True 46103851.806599095 58381088.12380933 35858606.610800505 1.0 1.266295240768862 0.7777789751976399 25.45838395174554 -6.7586605612444135 1.6172735091211752 1.1549352764423895 0.776096743937237 0.6855619030334534 0.11198487240631494 0.2851768721547898 1.469750678605569 0.05463862410614487 0.1314919665386685 1.7431687784901094e-07 6.7586605612444135 -0.3788385325051524 NNEDISIIPPLFTVSVDHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNEDISIIPPLFTVSVDHR 19 0 P51571;A6NLM8 P51571 SSR4 Translocon-associated protein subunit delta 0 16776100.0 6171200.0 2321500.0 8283400.0 False True 8452859.410409302 2218928.4538261048 6327031.521978033 1.0 0.262506253338793 0.7485078379733359 23.01100802425725 -9.812261016904284 5.81606983516313 1.000000061120551 0.50550704565718 0.5798905505250043 0.19840931609559956 268350824.18573946 80.34243914148983 219.85971197188988 0.06792078627704898 1.540774148348337e-10 9.812261016904284 -0.4944930154633711 NNEDISIIPPLFTVSVDHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NNEDISIIPPLFTVSVDHR 19 0 P51571;A6NLM8 P51571 SSR4 Translocon-associated protein subunit delta 0 28375610.0 12923000.0 6639100.0 8813510.0 False True 10746047.085969923 6603333.850541824 10656374.19193401 1.0 0.6144895697659057 0.9916552669722627 23.357302728841983 -10.812969932630386 10.092155543040125 1.0025513497152203 0.8030724186751625 0.2665856912432195 0.15397725110610622 0.008922419099499947 0.00016535193487057827 0.1504915748398063 0.0496959441023956 1.5382611345529114e-11 10.812969932630386 -0.19947893104005776 NNEDISIIPPLFTVSVDHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NNEDISIIPPLFTVSVDHR 19 0 P51571;A6NLM8 P51571 SSR4 Translocon-associated protein subunit delta 0 93534000.0 30390000.0 34624000.0 28520000.0 False True 39340454.07645816 32697143.963057898 23329652.639912017 1.0 0.8311328562581155 0.5930194042643951 25.229510273837988 -6.966264347712532 0.33564512833998267 1.0271650836299533 0.3891259003387708 0.9999368848801172 0.0013263131668457763 0.07753449738616289 0.013361276259221176 0.0034079959350108097 0.020676983733399573 1.08077590101795e-07 6.966264347712532 -0.6380391832911825 NNESQWK(ub)DSPLATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNESQWKDSPLATR 14 1 O95155-3;O95155-2;O95155;O95155-4;K7EP75 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 38612400.0 13872400.0 12436000.0 12304000.0 True False 18186850.740512695 10580597.275148334 11030900.108301999 1.0 0.5817718210871544 0.606531623626831 24.116392409818058 -10.592799479642677 6.412637052871589 1.000993423804617 0.5941517223569929 0.9972163301469251 0.010108147059045778 0.0001438840664099855 9.136584549223057e-06 0.00980901225428855 0.0032623904350583114 2.5538801957525e-11 10.592799479642677 -0.4068417014476241 NNESQWK(ub)DSPLATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNESQWKDSPLATR 14 1 O95155-3;O95155-2;O95155;O95155-4;K7EP75 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 38431530.0 14789000.0 9973400.0 13669130.0 True False 14319531.290089313 13955830.630593935 10088774.78788992 1.0 0.9746010779174665 0.7045464396500505 23.77148093498895 -6.925214462944064 0.7850772856308067 1.0049154163872334 0.655306763143223 0.9955112156362901 0.008957299055670949 0.09519992433916 0.09041875252746942 0.007939087096906263 0.02510885906815145 1.1879154671326822e-07 6.925214462944064 -0.34960865324401036 NNESQWK(ub)DSPLATR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NNESQWKDSPLATR 14 1 O95155-3;O95155-2;O95155;O95155-4;K7EP75 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 58285700.0 18443700.0 21035000.0 18807000.0 True False 27980441.315083012 17281139.90279488 15089788.206599085 1.0 0.6176149871331509 0.5392977200279129 24.73791538146977 -13.999999999999998 0.22289385015568836 3.337185984032469 0.49854984151587134 0.9995009564983055 0.004496297290241863 13.079996560334353 0.14954072090756243 13.476534662159281 0.042530299562850184 1.0000000000000041e-14 13.999999999999998 -2.838636142516598 NNESQWK(ub)DSPLATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNESQWKDSPLATR 14 1 O95155-3;O95155-2;O95155;O95155-4;K7EP75 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 37812400.0 13872400.0 12404000.0 11536000.0 True False 19001401.167513926 11855950.265457248 8811434.39137777 1.0 0.6239513686878513 0.46372550706641524 24.17960247134095 -13.999999999999998 0.11656566954317939 2.7978564169867775 0.1957477917342222 0.9997099464232485 0.0038279654775717443 11.978210590332644 0.10461508529748828 5.012900774598388 0.2377909101849286 1.0000000000000041e-14 13.999999999999998 -2.6021086252525554 NNESQWK(ub)DSPLATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NNESQWKDSPLATR 14 1 O95155-3;O95155-2;O95155;O95155-4;K7EP75 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 44005960.0 14789000.0 18979600.0 10237360.0 True False 12297708.763786206 18877353.12764436 12377944.64379545 1.0 1.5350301011545846 1.0065244576490149 23.551886210423227 -10.70973625383414 2.9643805694127 0.9626696457225443 1.2707772790784033 0.2592574266497756 0.21576152667054804 59543548.45211671 45389643.049596615 16277531.751083696 0.07896063214303052 1.951029096098701e-11 10.70973625383414 0.308107633355859 NNESQWK(ub)DSPLATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NNESQWKDSPLATR 14 1 O95155-3;O95155-2;O95155;O95155-4;K7EP75 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 53897100.0 18443700.0 25887300.0 9566100.0 True False 23875733.229679905 24446648.998234387 7825167.956474855 1.0 1.023911967982821 0.327745660466142 24.509041703562218 -6.898943516088924 0.9679016734560567 1.0297890556291442 0.25621376335287355 0.9860339407044112 0.03813459385026014 0.11218786253911825 0.1818289712667729 0.029606825230684055 0.07663335609481609 1.2619916573052652e-07 6.898943516088924 -0.7735752922762706 down NNFCGVGICYGSMNR ddPTM_RPMI8226_Bortezomib_1h_R1 2 NNFCGVGICYGSMNR 15 0 Q14258 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 0 50239400.0 17217300.0 13615200.0 19406900.0 False True 22572047.03257038 11583865.231633916 17398860.152129874 1.0 0.5131951574847844 0.7708144559075282 24.428033925001838 -10.14136396682309 5.1066100502484755 1.0000147624249063 0.6420048066956695 0.7202607487307784 0.105172638173282 1.7677132991358706e-05 2.97233990919488e-06 0.10183716472266223 0.033944323009908024 7.221643295780231e-11 10.14136396682309 -0.3580099557292368 NNFCGVGICYGSMNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNFCGVGICYGSMNR 15 0 Q14258 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 0 28596600.0 14312000.0 5654900.0 8629700.0 False True 19603533.167257242 5405047.819746385 6591542.5942504015 1.0 0.27571804396842886 0.33624258127406903 24.22461036056776 -10.419928955394074 5.418249837723878 1.000499346427391 0.3059803126212427 0.9943283362080282 0.024709038886165813 0.00014914678964630712 1.596747589528198e-05 0.023940698631752372 0.007974808008906134 3.802515951657009e-11 10.419928955394074 -0.6945190338061483 NNFEGEVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNFEGEVTK 9 0 P07237;H7BZ94;I3L398;I3L312;I3NI03;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 21603200.0 1567800.0 10440000.0 9595400.0 False True 2055400.9825967953 8882392.694801275 8602560.053576158 1.0 4.321488979527125 4.185343943305737 20.970988442146773 -10.17421501340631 4.4810175377666654 0.9993559561150902 4.253416461172922 0.9986883572477491 0.05558097859522155 9743363.211109014 80.41545142579908 65205.29782099001 0.019026847294777813 6.695530405643084e-11 10.17421501340631 3.2540605050578315 NNFEGEVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNFEGEVTK 9 0 P07237;H7BZ94;I3L398;I3L312;I3NI03;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 24483600.0 7067700.0 2150900.0 15265000.0 False True 6843339.732163387 3009765.5867953184 11266638.559816144 1.0 0.4398094650554255 1.6463655175357512 22.706269139922195 -6.780474030554129 1.534125268883536 0.6829932322727745 1.6560455064699595 0.7690007275270764 0.23694421110298716 0.24985552670591268 1.1615493176764002 0.12164545465725185 0.28690647014467197 1.6577764637104617e-07 6.780474030554129 0.973052274197185 NNFEGEVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNFEGEVTK 9 0 P07237;H7BZ94;I3L398;I3L312;I3NI03;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 21913300.0 1567800.0 10479000.0 9866500.0 False True 2147458.02820192 10016003.130580993 7536235.906945971 1.0 4.664120555113925 3.5093751812491107 21.034198503669664 -9.1158537219757 12.394884993700016 1.0000000000066407 4.086747867983607 0.9050086337380413 0.47142282480138326 0.0 0.0 0.45645318736944523 0.15215106245648172 7.658545167534238e-10 9.1158537219757 3.0867478679769658 NNFIPQPIGK(ub)CK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NNFIPQPIGKCK 12 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 10122000.0 2341500.0 2151800.0 5628700.0 True False 3031117.907865313 2032050.4384157779 4604334.355339165 1.0 0.6703963686608497 1.5190218577085315 21.531418542127398 -6.801387623297989 1.4503056508463206 0.81846334562532 1.5311335120942808 0.8361769599517828 0.14138537112710742 0.21877972402767587 0.9083660825297436 0.07668842471187691 0.17819517936653054 1.579837348698633e-07 6.801387623297989 0.7126701664689609 NNGAGYFLEHLAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNGAGYFLEHLAFK 14 0 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 9608280.0 917980.0 1510100.0 7180200.0 False True 1203480.6697309662 1284798.9663236975 6437261.781341841 1.0 1.0675692585996497 5.3488701092148565 20.198781538799867 -6.910330767282514 0.8934788974619832 0.8688252068356119 5.9060895396948645 0.9910458049785625 0.1925024895285197 0.10419969819306435 0.13758367157155252 0.15786257802311549 0.43677751016059035 1.2293321304672248e-07 6.910330767282514 5.037264332859253 up NNGAGYFLEHLAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNGAGYFLEHLAFK 14 0 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 10894480.0 917980.0 6626600.0 3349900.0 False True 1257382.0134767196 6333814.90076419 2558722.613356136 1.0 5.037303566360789 2.034960406568207 20.26199160032276 -6.57034571039929 2.3047212532760315 3.764950675214519 2.041078143394856 0.0 1.7581640750177003 0.7287066550741135 7.2664135873509315 0.6444531676295158 1.971095767425234 2.6893931204372926e-07 6.57034571039929 -1.723872531819663 NNGVLFENQLLQIGVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNGVLFENQLLQIGVK 16 0 O95782;O95782-2 O95782 AP2A1 AP-2 complex subunit alpha-1 0 4179500.0 3116100.0 1063400.0 0.0 False True 3017181.111166905 1488021.1655577424 0.0 1.0 0.4931825802734941 0.0 21.524769868506855 -7.949973548623499 0.5887730749391828 1.0116578945545651 1.2499211017442277e-18 0.9891680004270555 0.042490529591821896 0.11202678382752142 0.1625279542367172 0.04523430269568185 0.07678088629677397 1.1220867946508557e-08 7.949973548623499 -1.0116578945545651 NNHFSTMTK(ub)HK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNHFSTMTKHK 11 1 Q8N5J2-2;Q8N5J2-4;Q8N5J2;Q8N5J2-3 Q8N5J2-2 FAM63A Protein FAM63A 1 16235800.0 2336900.0 3991400.0 9907500.0 True False 3063698.5305717895 3395898.6783553455 8882366.93945074 1.0 1.1084310823890222 2.8992300811636946 21.546842911676162 -6.919293399826353 0.8299493038296304 0.9594717261795319 3.1833718014853405 0.9939823907925615 0.06755652451440405 0.0985894110202973 0.10778143747491623 0.057990065171810004 0.17255195461665235 1.2042221194519357e-07 6.919293399826353 2.2239000753058087 up NNHFSTMTK(ub)HK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNHFSTMTKHK 11 1 Q8N5J2-2;Q8N5J2-4;Q8N5J2;Q8N5J2-3 Q8N5J2-2 FAM63A Protein FAM63A 1 14164100.0 1889300.0 2832700.0 9442100.0 True False 1829325.2056505366 3963811.8823353555 6968930.753071747 1.0 2.1668164141026867 3.809563620260448 20.802880140241086 -6.966289008310598 0.33519366917175536 0.8116021511724149 5.218976001466633 0.9999373033671592 0.009125410868925942 0.07752622489160974 0.013332343527762693 0.02354674706815152 0.14270000179794232 1.0807145329266876e-07 6.966289008310598 4.407373850294218 NNHFSTMTK(ub)HK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNHFSTMTKHK 11 1 Q8N5J2-2;Q8N5J2-4;Q8N5J2;Q8N5J2-3 Q8N5J2-2 FAM63A Protein FAM63A 1 16362000.0 2336900.0 3060100.0 10965000.0 True False 3200915.082347919 2924894.6636025244 8375292.831263626 1.0 0.9137682782440673 2.6165307781674185 21.610052973199053 -6.894976395217897 0.992505629165717 0.9191212883771752 2.778083712790494 0.9838961261246203 0.09938338172665001 0.11519727323815061 0.19901740309098848 0.0757553243570996 0.19257112984250968 1.2735723003619068e-07 6.894976395217897 1.8589624244133187 up NNHFSTMTK(ub)HK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NNHFSTMTKHK 11 1 Q8N5J2-2;Q8N5J2-4;Q8N5J2;Q8N5J2-3 Q8N5J2-2 FAM63A Protein FAM63A 1 9438400.0 1889300.0 2070800.0 5478300.0 True False 1571036.660181305 2059644.1893783852 6623787.201202716 1.0 1.3110096292346818 4.216188819195537 20.583285415675363 -6.927332678540256 0.7683731692277523 0.951176310051961 4.774016343021523 0.9959875140103052 0.09174747832847246 0.09404664317161243 0.08464066828073279 0.08229651977295932 0.2668278188357551 1.1821356684750332e-07 6.927332678540256 3.8228400329695615 up NNIFYILLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NNIFYILLR 9 0 O14802 O14802 POLR3A DNA-directed RNA polymerase III subunit RPC1 0 17776800.0 3553900.0 5487600.0 8735300.0 False True 5391526.124892165 4508294.905185502 7008764.126181993 1.0 0.8361815932544835 1.299959225612057 22.36226226923575 -6.811247293873456 1.4093619733035558 0.910850513538599 1.30829981442375 0.8630310409442012 0.07107134917107849 0.20511156962129995 0.8027501560271901 0.03964969671950327 0.09166379043058924 1.5443747986575718e-07 6.811247293873456 0.39744930088515107 NNIFYILLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NNIFYILLR 9 0 O14802 O14802 POLR3A DNA-directed RNA polymerase III subunit RPC1 0 13945100.0 3553900.0 6175200.0 4216000.0 False True 4600593.607842217 5831544.6915629385 3448731.259813083 1.0 1.267563533893198 0.74962745110421 22.1333885913282 -6.766290066455456 1.5884916853212285 1.1541956901574557 0.7471042017732922 0.7161953808518158 0.11266525358671767 0.27248948141990037 1.3563275575815423 0.0559229517283746 0.1335868490319621 1.7128129330093277e-07 6.766290066455456 -0.40709148838416354 NNIK(ub)LYVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNIKLYVR 8 1 P08238;Q58FF7;P07900;P07900-2 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1 Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha 1 16771400.0 4433600.0 5214400.0 7123400.0 True False 5812492.535043474 4436431.845572007 6386338.90047777 1.0 0.7632580719587668 1.0987263832124652 22.470725527587014 -6.717119915726285 1.7700277047100976 0.8555260650401935 1.0981089362994192 0.498765778481456 0.09965853665912039 0.3609270335138852 2.2083941431088205 0.044736763373140365 0.11267340682159925 1.9181390383511407e-07 6.717119915726285 0.24258287125922573 NNIK(ub)LYVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNIKLYVR 8 1 P08238;Q58FF7;P07900;P07900-2 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1 Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha 1 20954600.0 7035700.0 6426500.0 7492400.0 True False 6812355.554647462 8992634.963754764 5529915.67281799 1.0 1.3200478001504035 0.8117479524458207 22.699722304331843 -6.736471772525989 1.699295670557706 1.1911930144369542 0.811653103937668 0.5891899285791096 0.13448611157165374 0.3242113570208849 1.8367471885771738 0.06264144290192841 0.15433472729172268 1.8345444015858458e-07 6.736471772525989 -0.37953991049928626 NNIK(ub)LYVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NNIKLYVR 8 1 P08238;Q58FF7;P07900;P07900-2 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1 Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha 1 71953000.0 18574000.0 22422000.0 30957000.0 True False 28178115.94128898 18420618.916114397 24838335.381064903 1.0 0.6537207439452307 0.8814760870747094 24.748071816915605 -10.3879116323095 6.76636175279463 1.0000167736572407 0.7675984155099701 0.581290132918132 0.09298072947662019 2.3529222698738083e-05 2.128470969027341e-06 0.09003469538641952 0.030009401398430578 4.093439421580251e-11 10.3879116323095 -0.23241835814727063 NNIK(ub)LYVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNIKLYVR 8 1 P08238;Q58FF7;P07900;P07900-2 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1 Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha 1 14056700.0 4433600.0 4356100.0 5267000.0 True False 6072821.733534914 4163633.098303642 4023043.0772699923 1.0 0.6856175400821527 0.6624668488215656 22.533935589109905 -13.999999999999998 0.37015968675409466 5.383497833691568 0.660072822200945 0.9997911733220904 0.0022246752890909003 22.83813590435628 0.1974919929588912 79.44363056985469 0.006466835738811644 1.0000000000000041e-14 13.999999999999998 -4.723425011490623 NNIK(ub)LYVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NNIKLYVR 8 1 P08238;Q58FF7;P07900;P07900-2 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1 Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha 1 21063900.0 7035700.0 8065800.0 5962400.0 True False 5850496.284358007 8022347.9344640495 7209110.272977212 1.0 1.3712251994608977 1.2322220069178782 22.48012757976612 -10.151791066235793 5.247561958692899 0.9999893197762414 1.301723603189568 0.8626777681886946 0.056747815725336284 7.090974795092875e-06 1.1460930020704566e-06 0.05494777999016721 0.0183152787697322 7.05032169746934e-11 10.151791066235793 0.30173428341332664 NNIK(ub)LYVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NNIKLYVR 8 1 P08238;Q58FF7;P07900;P07900-2 P08238;Q58FF7;P07900 HSP90AB1;HSP90AB3P;HSP90AA1 Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha 1 56018000.0 18574000.0 21615000.0 15829000.0 True False 24044409.14827688 20412106.24888797 12948284.419255525 1.0 0.8489335763258207 0.5385153920566791 24.519198139008054 -6.9595122909797995 0.44225446769043025 1.0108419158286794 0.36445890039022405 0.999751678003256 0.003027274038331764 0.07987581120243317 0.021778606643601126 0.0041044258746566155 0.025709374152564243 1.0977102235075798e-07 6.9595122909797995 -0.6463830154384553 NNLK(ub)ECGLY ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNLKECGLY 9 1 P08754 P08754 GNAI3 Guanine nucleotide-binding protein G(k) subunit alpha 1 8407900.0 2877100.0 4191500.0 1339300.0 True False 3771905.961876037 3566144.5383390365 1200722.0834727613 1.0 0.9454489519047657 0.31833298486464834 21.846862277673804 -6.924022758081482 0.7943249574026491 1.0119358109848553 0.20721703438667927 0.9952272593659781 0.02136702649545358 0.09586243845853534 0.09377120588236872 0.018813561993860917 0.0587180641720574 1.1911795856998974e-07 6.924022758081482 -0.804718776598176 down NNLK(ub)ECGLY ddPTM_RPMI8226_Bortezomib_8h_R1 1 NNLKECGLY 9 1 P08754 P08754 GNAI3 Guanine nucleotide-binding protein G(k) subunit alpha 1 14199400.0 4609200.0 7033500.0 2556700.0 True False 6992493.377656366 5778316.972013671 2051367.1243585793 1.0 0.8263600206583759 0.2933670457112573 22.737375551700744 -6.950934556853643 0.5484893258973639 1.007438000967731 0.08731469630523389 0.9992725871661693 0.00810894905886073 0.08311266166759573 0.03442619893428934 0.008818442190779778 0.04420380664294256 1.1196065824957066e-07 6.950934556853643 -0.9201233046624971 down NNLK(ub)ECGLY ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNLKECGLY 9 1 P08754 P08754 GNAI3 Guanine nucleotide-binding protein G(k) subunit alpha 1 7852400.0 2877100.0 3373200.0 1602100.0 True False 3940841.6207040153 3224160.870319285 1223716.9762852208 1.0 0.8181401793415138 0.3105217347117362 21.910072339196695 -6.9530599627835095 0.5241772882452843 1.0083556368252713 0.09749081725753696 0.999420043808154 0.0070263108471378495 0.08227983285150775 0.031053837031106788 0.007908006065609664 0.041947911610231495 1.1141406942218025e-07 6.9530599627835095 -0.9108648195677344 down NNLK(ub)ECGLY ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NNLKECGLY 9 1 P08754 P08754 GNAI3 Guanine nucleotide-binding protein G(k) subunit alpha 1 11668200.0 4609200.0 4368000.0 2691000.0 True False 5966700.260915147 4124916.96021941 2201265.6119917003 1.0 0.6913229724710099 0.3689251203736652 22.508501873793193 -7.113360966032093 0.26133336204643415 1.0963228334608348 2.7062979948554067e-12 0.9999754442478462 0.001276767037692999 0.07791680359105993 0.01061855833641049 0.008337507896743685 0.032402316772300446 7.702629949915603e-08 7.113360966032093 -1.0963228334581285 down NNLNPVWRPFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNLNPVWRPFK 11 1 O75131;A0A087WYQ3;H0YB26 O75131 CPNE3 Copine-3 0 33270500.0 8440800.0 9128700.0 15701000.0 False True 11065970.540823475 7766733.5433939025 14076411.134626929 1.0 0.7018574208870016 1.2720448769222399 23.39962665245206 -6.764613540244372 1.5948830789551611 0.8278138528690621 1.2746306180188558 0.7095384538382725 0.12549832767876265 0.27526585524990893 1.3808929501451104 0.06205327865940131 0.14846575195569683 1.71943775941479e-07 6.764613540244372 0.44681676514979374 NNLNPVWRPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNLNPVWRPFK 11 1 O75131;A0A087WYQ3;H0YB26 O75131 CPNE3 Copine-3 0 23235900.0 7432500.0 2348400.0 13455000.0 False True 7196559.355844803 3286128.3667442123 9930731.858652228 1.0 0.45662492369709 1.3799277359654962 22.778875894398997 -6.747220126759881 1.6600419247380307 0.67942304869504 1.3813891375734948 0.636934128552407 0.22830623960817703 0.3049324810758965 1.6524138497115897 0.10868178399781181 0.26463410302026713 1.7896984964564737e-07 6.747220126759881 0.7019660888784548 NNLNPVWRPFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNLNPVWRPFK 11 1 O75131;A0A087WYQ3;H0YB26 O75131 CPNE3 Copine-3 0 30129800.0 8440800.0 8747200.0 12941800.0 False True 11561591.864043104 8360719.7808777485 9885213.384737583 1.0 0.7231460753150989 0.855004527143091 23.46283671397495 -10.103349702600187 4.644661903511706 1.0000140479118969 0.7890753012255225 0.7733327640629953 0.053830987557105574 8.048377121883279e-06 1.5536713244569008e-06 0.05212519613837318 0.017373876524407306 7.88225167350875e-11 10.103349702600187 -0.21093874668637436 NNLNPVWRPFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NNLNPVWRPFK 11 1 O75131;A0A087WYQ3;H0YB26 O75131 CPNE3 Copine-3 0 17172400.0 7432500.0 3600900.0 6139000.0 False True 6180453.065578535 3581501.236977308 7422636.516471062 1.0 0.5794884612786965 1.2009858238080884 22.559281169833273 -6.724459751060163 1.743211341007258 0.7453931472159068 1.2002728695335063 0.5335011799600546 0.17686299774487452 0.3467231381598615 2.061381207032061 0.08048547781508013 0.20100088930845417 1.885993748896311e-07 6.724459751060163 0.45487972231759954 NNLNPVWRPFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NNLNPVWRPFK 11 1 O75131;A0A087WYQ3;H0YB26 O75131 CPNE3 Copine-3 0 22093900.0 5613900.0 5250300.0 11229700.0 False True 7267304.216512962 4958116.18961538 9186009.826452315 1.0 0.6822497093694545 1.2640188923947369 22.79298886954595 -6.758402121423318 1.61841753614827 0.8150621902016489 1.2659811424643654 0.6843907374259469 0.13361847517504474 0.28563423438306695 1.4741593391585661 0.06515169365920054 0.15682202781697654 1.7442064115146552e-07 6.758402121423318 0.4509189522627165 NNLSLGDALAK(ub)WEECQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NNLSLGDALAKWEECQR 17 1 Q96AD5;Q96AD5-2 Q96AD5 PNPLA2 Patatin-like phospholipase domain-containing protein 2 1 49969600.0 2253600.0 18789000.0 28927000.0 True False 3418875.9602287505 15435956.15087296 23209565.770845503 1.0 4.514921374872041 6.788653943822108 21.70509065082345 -8.266026822656492 0.30294709549578946 5.871850766048524e-18 8.080228204579939 0.9988299215834772 0.08145391743906549 0.10310410018586529 0.07464576108729835 0.6318919481939054 0.6928179653704782 5.419674166749803e-09 8.266026822656492 8.080228204579939 NNLSLGDALAK(ub)WEECQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NNLSLGDALAKWEECQR 17 1 Q96AD5;Q96AD5-2 Q96AD5 PNPLA2 Patatin-like phospholipase domain-containing protein 2 1 40698600.0 2253600.0 16293000.0 22152000.0 True False 2917329.6250972725 15386280.227301916 18120563.298714306 1.0 5.274097275445483 6.211352718879038 21.4762169729159 -9.46185645641192 0.4613291632022256 2.143096754129949e-19 6.249531578914425 0.9982265543668009 0.09552114718422998 0.7971667641460789 0.19351869955571796 1.6018027936820693 0.20412398506009832 3.452578355568572e-10 9.46185645641192 6.249531578914425 NNPAIVIIGNNGQIHYDHQNDGASQALASCQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNPAIVIIGNNGQIHYDHQNDGASQALASCQR 32 0 P49257 P49257 LMAN1 Protein ERGIC-53 0 6837600.0 1624200.0 2100600.0 3112800.0 False True 2224710.632354613 2007788.5462447216 2377620.750128355 1.0 0.9024942466875779 1.0687325873081766 21.08518626656461 -6.747767252089589 1.6583482990904659 0.9425107615983671 1.0690025053911776 0.6391901274268406 0.04096872522390397 0.3039650995423472 1.644046856262994 0.01952234534985019 0.04750215239066533 1.7874452492083945e-07 6.747767252089589 0.12649174379281047 NNPHYDPSSK(ub)EDNPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NNPHYDPSSKEDNPK 15 1 Q9P016-2;Q9P016 Q9P016-2 THYN1 Thymocyte nuclear protein 1 1 2093720.0 1003800.0 691430.0 398490.0 True False 834704.175879952 687705.1293518904 481812.4165904149 1.0 0.8238908456722479 0.5772253578131249 19.670905462910415 -6.966371190876627 0.3336833307437694 1.0287898700531142 0.36420672601827614 0.9999386820932401 0.0013577809897497206 0.07749870077076101 0.013235910403201 0.003553524438722969 0.021452034076307556 1.0805100461227538e-07 6.966371190876627 -0.664583144034838 NNPLYHAGAVAFSISAGIPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NNPLYHAGAVAFSISAGIPK 20 0 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 0 15859100.0 4179200.0 4386600.0 7293300.0 False True 5410056.784347952 4142481.8538686987 5965994.235577503 1.0 0.7657002539887336 1.1027600029703857 22.367212306087403 -6.719792812062338 1.7603270349195175 0.8574195183354896 1.1022182867339754 0.5113946557800741 0.09859695994494865 0.3557327935911644 2.154253171080814 0.044477625033297864 0.11167145625759622 1.9063699688939587e-07 6.719792812062338 0.2447987683984858 NNPSKPLHVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNPSKPLHVIK 11 1 O75083;O75083-3 O75083 WDR1 WD repeat-containing protein 1 0 3412450.0 955090.0 564760.0 1892600.0 False True 924771.1907398346 790271.6131844938 1396871.283217037 1.0 0.8545590748261324 1.5105047575060306 19.81873692891017 -6.848549092930344 1.2421463974207458 0.9224758466708366 1.5359912115484724 0.9381567500816486 0.06994794004290217 0.1590611784680957 0.4730137534020609 0.04408131762202533 0.10191225907276438 1.4172644938884138e-07 6.848549092930344 0.6135153648776358 NNQETK(ub)PSDDENSDNSNECVVCLSDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNQETKPSDDENSDNSNECVVCLSDLR 27 1 O60291-4;O60291;O60291-3;O60291-2;B4DR12;K7EIM7 O60291-4 MGRN1 E3 ubiquitin-protein ligase MGRN1 1 6877400.0 1711600.0 3085400.0 2080400.0 True False 2243924.175157976 2625070.346795003 1865140.1646059384 1.0 1.1698569746057457 0.8311957174197429 21.097592495729085 -6.770325719911283 1.5730900971892032 1.0973834644177525 0.8292617517166331 0.7318620835378129 0.07159285877645515 0.2658949962918432 1.2985862082591997 0.035871155766174945 0.08536681403890574 1.6969704509466516e-07 6.770325719911283 -0.2681217127011194 NNQETK(ub)PSDDENSDNSNECVVCLSDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNQETKPSDDENSDNSNECVVCLSDLR 27 1 O60291-4;O60291;O60291-3;O60291-2;B4DR12;K7EIM7 O60291-4 MGRN1 E3 ubiquitin-protein ligase MGRN1 1 8876900.0 1711600.0 2511100.0 4654200.0 True False 2344424.774250801 2400151.298902753 3554973.816257834 1.0 1.02376980710322 1.5163522648722578 21.160802557251976 -6.916950729690553 0.8470245266290863 0.9878917168303867 1.590472032235477 0.9932912922246748 0.019494293968347082 0.09999958446579045 0.11515344774320252 0.016530537791922803 0.0481617488259431 1.2107354825859687e-07 6.916950729690553 0.6025803154050904 NNQFQALLQYADPVNAHYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNQFQALLQYADPVNAHYAK 20 0 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2 O95758-1 PTBP3 Polypyrimidine tract-binding protein 3 0 6505800.0 1295300.0 2292300.0 2918200.0 False True 1774207.414166315 2191018.6063775932 2228981.2622155496 1.0 1.2349281086772677 1.2563250747449553 20.758743247450962 -12.629183382144543 0.36015115927123237 5.733602415911311e-21 1.259026710312306 0.9997082444889799 0.0019833948265593378 8.225851672432224 0.19083101122429588 6.130699916266499 0.006171389411033409 2.348640890796245e-13 12.629183382144543 1.259026710312306 NNQFQALLQYADPVSAQHAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNQFQALLQYADPVSAQHAK 20 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68;K7EKJ7 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 121354500.0 22411600.0 64229300.0 34713600.0 False True 29381824.634243138 54646538.80385053 31121769.66836414 1.0 1.8598756028297356 1.0592184132803373 24.80842065537583 -10.445608925276787 4.387094379359448 0.9983011176481381 1.4595470080559356 0.30519057022639384 0.3268669288846565 0.005449875068177444 0.0006886923614684355 0.31756277396148685 0.10549584766586236 3.584190420232818e-11 10.445608925276787 0.4612458904077975 NNQFQALLQYADPVSAQHAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNQFQALLQYADPVSAQHAK 20 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68;K7EKJ7 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 123705400.0 47400400.0 22274000.0 54031000.0 False True 45895700.24766723 31168124.35737553 39878660.20474461 1.0 0.6791077200954077 0.8688975217623255 25.451855664867303 -10.247666908024906 5.472611684240678 1.0000172534462806 0.7740026220404421 0.6540511360004204 0.07748136207804102 1.63118927482218e-05 2.242327108981824e-06 0.07502672999387516 0.025007002080803285 5.653704322057299e-11 10.247666908024906 -0.22601463140583844 NNQFQALLQYADPVSAQHAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NNQFQALLQYADPVSAQHAK 20 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68;K7EKJ7 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 145734400.0 15357000.0 114921400.0 15456000.0 False True 23297691.74708599 94412778.28500351 12401114.82539455 1.0 4.0524520330136315 0.5322894199141273 24.47368368904842 -6.677407969425131 1.911037427690056 2.9358223550114353 0.5459483293214945 0.31227197586358 1.294446944848297 0.4443416500276264 3.1351435676739023 0.5439577931802397 1.4394651521903028 2.1018031112359196e-07 6.677407969425131 -2.3898740256899407 NNQFQALLQYADPVSAQHAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNQFQALLQYADPVSAQHAK 20 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68;K7EKJ7 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 109897940.0 22411600.0 42358340.0 45128000.0 False True 30697774.170717057 40486808.47850119 34469695.84033423 1.0 1.3188841722968307 1.122872806628933 24.87163071689872 -10.23183019564204 4.063753016814172 0.9998369009203716 1.220878489455887 0.6286809502831727 0.08002130505259936 56428790.58625838 26.039428587994337 88132.80458998175 0.02739342114540668 5.863673828870924e-11 10.23183019564204 0.22104158853551548 NNQFQALLQYADPVSAQHAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NNQFQALLQYADPVSAQHAK 20 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68;K7EKJ7 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 78959400.0 47400400.0 14142000.0 17417000.0 False True 39415532.793763794 14065814.239032766 21058814.172890797 1.0 0.35685967541350133 0.5342770395386526 25.23226094030158 -10.824294647958519 10.85939129393341 1.006851644764313 0.4455683574767191 0.9286781312972067 0.0724303356026977 0.011816630518139241 0.00019119311583454878 0.06897263096601763 0.023376790295788517 1.4986677164031627e-11 10.824294647958519 -0.5612832872875939 NNQFQALLQYADPVSAQHAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NNQFQALLQYADPVSAQHAK 20 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EK45;A0A087WU68;K7EKJ7 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 64783000.0 15357000.0 30345000.0 19081000.0 False True 19879939.231726516 28656274.07460119 15608453.787593326 1.0 1.4414668848116228 0.7851358902890256 24.24481001114087 -6.725489290981155 1.7395881811692668 1.2669995820391573 0.7858315580710865 0.5382487131509328 0.18565749624679556 0.3447723803234223 2.041801712747513 0.08464800141535699 0.2111365699650614 1.8815281011699614e-07 6.725489290981155 -0.4811680239680708 NNQGTVNWSVDDIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNQGTVNWSVDDIVK 15 0 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 0 23873400.0 7347900.0 9545000.0 6980500.0 False True 9633168.057164812 8120923.2061185865 6258224.82168417 1.0 0.8430168723235892 0.6496538609673193 23.199578904124206 -6.968324365298723 0.2954793101316041 1.0353892796573834 0.45126122669167235 0.9999662026446917 0.0008329745205064541 0.07685024469948973 0.010965888532364562 0.003282118007101057 0.01742682209832638 1.0756615248552178e-07 6.968324365298723 -0.584128052965711 NNQGTVNWSVDDIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNQGTVNWSVDDIVK 15 0 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 0 18114100.0 4641200.0 2706900.0 10766000.0 False True 4493867.6464644335 3787779.28629702 7946061.626923083 1.0 0.8428773573865863 1.7682010802375712 22.099526204166594 -6.863185394218243 1.169444618070741 0.9139092068137018 1.8158337434453278 0.9574012527659116 0.0834430271265612 0.14356154252198708 0.3712675823266242 0.05557249805842991 0.13023227489434336 1.3702966808728332e-07 6.863185394218243 0.901924536631626 NNQGTVNWSVDDIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNQGTVNWSVDDIVK 15 0 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 0 13568400.0 7347900.0 6220500.0 0.0 False True 10064617.199531117 5945657.741557301 0.0 1.0 0.5907485226397178 0.0 23.262788965647097 -7.6748935374825535 0.6544520774241096 0.9992540168626689 4.887956468383582e-15 0.9873690252031525 0.046133262873386455 0.12064061710965299 0.1499612579936858 0.042673526388897876 0.07773677345348054 2.11400720194657e-08 7.6748935374825535 -0.999254016862664 down NNQGTVNWSVDDIVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NNQGTVNWSVDDIVK 15 0 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 0 9797300.0 4641200.0 2515000.0 2641100.0 False True 3859363.4400219438 2501451.195811587 3193341.798933334 1.0 0.6481512391062512 0.8274270740656592 21.87993147960087 -10.27897952427678 4.680954322249145 1.0001105561256682 0.7377891565853292 0.7404154009096762 0.07318905314596119 8.447955347408914e-05 1.3012530249994493e-05 0.07089477211103092 0.023621665329590858 5.2604206716140284e-11 10.27897952427678 -0.26232139954033906 NNQGTVNWSVDDIVK(ub)GINSSNVENQLQATQAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NNQGTVNWSVDDIVKGINSSNVENQLQATQAAR 33 1 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 1 66600400.0 4517000.0 7467400.0 54616000.0 True False 5847345.54338143 7051832.625627843 44676448.40748377 1.0 1.205988695778337 7.640466614471371 22.47935041786585 -6.913718144485265 0.8700380968976684 0.8234322914155355 8.54168353583928 0.9922505600720978 0.27139409259248487 0.10201016300404264 0.1258125285969904 0.22636262780505617 0.6421903392817188 1.2197809754448037e-07 6.913718144485265 7.718251244423744 up NNQK(ub)CDSVEEETGINR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NNQKCDSVEEETGINR 16 1 P04035-2;P04035;P04035-3 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 66712200.0 1940200.0 22297000.0 42475000.0 True False 2943425.2476197323 18317926.142743856 34079797.63254615 1.0 6.223336623736942 11.57827862627242 21.489064558191846 -7.395611360161967 0.31393413060737096 1.0464029272113152e-19 15.679272466366033 0.999663028112857 0.07927703770165935 0.13126510496500346 0.03127503230262687 0.28162876969041867 0.9524973578289848 4.021505248479226e-08 7.395611360161967 15.679272466366033 NNQK(ub)CDSVEEETGINR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NNQKCDSVEEETGINR 16 1 P04035-2;P04035;P04035-3 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 56742200.0 1940200.0 16626000.0 38176000.0 True False 2511627.1470596977 15700748.484571418 31228359.718838774 1.0 6.251225825040119 12.433517353639482 21.260190880284295 -7.1450140875021 0.3128579145323125 2.207621346063512e-25 17.799242867668482 0.999919131250222 0.0420217420749849 0.09034945017159966 0.016436257210999214 0.1470060669752927 0.673194386823657 7.161201805643773e-08 7.1450140875021 17.799242867668482 NNQLDPTSK(ub)EDFLNICIEPDTISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NNQLDPTSKEDFLNICIEPDTISK 24 1 A0A3B3ISZ0;Q53H12;A0A3B3ISY9;E9PC15;A0A3B3ITD0;A0A0G2JLG5 A0A3B3ISZ0 AGK Acylglycerol kinase, mitochondrial 1 32122600.0 4440600.0 10070000.0 17612000.0 True False 6736714.851345325 8272929.822730881 14130980.480386164 1.0 1.228036217248942 2.097607037288242 22.68361380419096 -6.945973633736931 0.6014255989670355 0.9902354278192994 2.3800306335318795 0.9988462344700929 0.01606379200869363 0.08514394387241535 0.04297210537628129 0.0164638533728112 0.07311065492138058 1.132469113987551e-07 6.945973633736931 1.3897952057125802 up NNQSK(ub)FFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNQSKFFR 8 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y8B3;K7EMY3;Q8TDI0;Q12873-3;Q12873;Q12873-2;A0A5F9ZHX5;F2Z2R5 A0A2R8YFD8 CHD4;CHD5;CHD3 Chromodomain-helicase-DNA-binding protein 4;Chromodomain-helicase-DNA-binding protein 5;Chromodomain-helicase-DNA-binding protein 3 1 3218000.0 1177600.0 1027700.0 1012700.0 True False 1543845.0038946236 874371.1659432241 907915.5185043422 1.0 0.5663594232176594 0.588087221329838 20.55809648816261 -10.145975667151951 5.238996432390999 1.0000141866739878 0.5772233222734745 0.9980229785586046 0.008870336435827816 1.4698791261737582e-06 2.396357427101561e-07 0.008588954155715613 0.002862888774125975 7.145363593209609e-11 10.145975667151951 -0.4227908644005133 NNQVLGIGSGSTIVHAVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNQVLGIGSGSTIVHAVQR 19 0 P49247 P49247 RPIA Ribose-5-phosphate isomerase 0 9155500.0 2095200.0 3506900.0 3553400.0 False True 2746827.4899456613 2983684.189789138 3185728.2546196594 1.0 1.0862291864743796 1.159784611986201 21.389334876456193 -6.972971896937633 0.173056362101605 0.9376260558087866 1.3103633131850962 0.9999972423030475 0.00010828569425581329 0.07534966540305735 0.005415864129418222 0.0030144495031630596 0.00843662910109126 1.0642118808197884e-07 6.972971896937633 0.3727372573763097 NNQVLGIGSGSTIVHAVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNQVLGIGSGSTIVHAVQR 19 0 P49247 P49247 RPIA Ribose-5-phosphate isomerase 0 8832700.0 2095200.0 3345000.0 3392500.0 False True 2869852.0606510174 3197206.839564217 2591261.3707306767 1.0 1.114066778354749 0.9029250692953339 21.452544937979084 -6.759956857258281 1.6124546892788045 1.0662585658227393 0.9021502696093048 0.6908801375266329 0.04797667350811589 0.2829796379522617 1.4500539913436623 0.023475280837751304 0.05642120999116237 1.7379734701700894e-07 6.759956857258281 -0.16410829621343448 NNSDK(ub)DQSLGNWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNSDKDQSLGNWR 13 1 Q03252 Q03252 LMNB2 Lamin-B2 1 8930300.0 3985200.0 3270200.0 1674900.0 True False 5224635.792731692 2782298.907139758 1501597.4147752794 1.0 0.5325345186759971 0.2874070986659477 22.31689904032946 -9.505026020744246 0.17859134611189095 1.5401292718223611 1.5887658025306003e-20 0.9996331610751382 0.0056615845522228776 0.937076579504541 0.07060777751925681 0.42452168610527846 0.16029949331260962 3.125892073758936e-10 9.505026020744246 -1.5401292718223611 NNSDK(ub)DQSLGNWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NNSDKDQSLGNWR 13 1 Q03252 Q03252 LMNB2 Lamin-B2 1 21268300.0 8790400.0 5776800.0 6701100.0 True False 13335679.464321446 4745884.905655591 5376624.647803532 1.0 0.35587874756234433 0.40317590582379137 23.668787997524376 -9.963175081599713 7.279786602813135 1.0000000175735098 0.37952732669306755 0.9956609211566104 0.01930898400403582 5.494523049640827e-09 7.845134973735726e-10 0.01869584406642628 0.00623194778998449 1.0884911902247163e-10 9.963175081599713 -0.6204726908804422 NNSDK(ub)DQSLGNWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NNSDKDQSLGNWR 13 1 Q03252 Q03252 LMNB2 Lamin-B2 1 21435100.0 8790400.0 7854200.0 4790500.0 True False 11379346.08468897 7417106.865603311 3918678.1546808807 1.0 0.6518043137455065 0.3443676047390371 23.439914319616825 -7.460316488222747 0.24305504882706033 1.1375193320253039 1.1927605760456461e-15 0.9998986382684091 0.002696499579556982 0.12392795228880027 0.02200677023227839 0.024889094891913502 0.061791193467489604 3.4648426111856045e-08 7.460316488222747 -1.1375193320253028 down NNSELLNNLGNFINR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNSELLNNLGNFINR 15 0 P56192 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 7977800.0 1283000.0 4939800.0 1755000.0 False True 1682025.4245896728 4202801.095189587 1573409.435148734 1.0 2.4986549155253424 0.9354254770153456 20.68176808208264 -6.655700362355852 1.987770234034894 1.9680217754381866 0.9419212157436332 0.21770106244716103 0.6387463862026828 0.49467938796738137 3.7525975297576277 0.26000641481373776 0.7079621462356114 2.2095286520405447e-07 6.655700362355852 -1.0261005596945534 NNSELLNNLGNFINR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNSELLNNLGNFINR 15 0 P56192 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 13786200.0 6009600.0 3169100.0 4607500.0 False True 5818828.537488728 4434538.15663818 3400657.5279628523 1.0 0.7621015343669199 0.5844230511439846 22.472297304370404 -6.996714981985725 0.11515500383353283 1.3459424207942734 3.320072056430608e-15 0.9999995620404226 0.00011252175420182834 0.07288456356270002 0.003381762736564937 0.013194503054077178 0.025924897914930887 1.0075927130768219e-07 6.996714981985725 -1.34594242079427 NNSELLNNLGNFINR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNSELLNNLGNFINR 15 0 P56192 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 14665300.0 1283000.0 5780300.0 7602000.0 False True 1757359.7717713127 5524907.23310405 5806564.168104519 1.0 3.1438680467433695 3.3041408261279663 20.744978143605532 -10.332212983561185 0.5388749054988724 2.6999075932057317e-18 3.292927933576264 0.9996199825139558 0.020477423631714592 1.6715110915696063 0.255810004121698 2.480307990679796 0.030383439215420558 4.653578201344149e-11 10.332212983561185 3.292927933576264 NNSELLNNLGNFINR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NNSELLNNLGNFINR 15 0 P56192 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 9877800.0 6009600.0 1463800.0 2404400.0 False True 4997248.670420558 1455914.2188584483 2907148.9233104796 1.0 0.29134315998245525 0.5817499018046304 22.25270257980468 -10.435500154968254 6.06163299100039 1.0002133374860311 0.4365465308942219 0.833867185517766 0.11855805588808384 0.00034194020234078036 3.184382622033592e-05 0.11483578086340976 0.03826444800110635 3.668595635357038e-11 10.435500154968254 -0.5636668065918092 NNSLHDMK(ub)TVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNSLHDMKTVVK 12 1 H0Y4W2;F2Z2U4;Q9Y4A5-2;Q9Y4A5;A0A2R8YFJ4 H0Y4W2 TRRAP Transformation/transcription domain-associated protein 1 3322740.0 805180.0 989360.0 1528200.0 True False 1055598.7773742124 841751.344495074 1370076.5235295102 1.0 0.7974159903717576 1.2979140871473507 20.00963015412981 -6.796804150778425 1.4687518833575093 0.8877710196651062 1.304304963616275 0.8227250527387144 0.08654872924181471 0.2253374055161161 0.9599615392928562 0.04636352989348991 0.10804943386120902 1.5965989863929085e-07 6.796804150778425 0.4165339439511687 NNTQVLINCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNTQVLINCR 10 0 P62316;K7ERG4;P62316-2 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 56749000.0 15821000.0 19014000.0 21914000.0 False True 20741484.210781958 16177185.315991491 19646549.493931226 1.0 0.7799434771202233 0.9472103970128832 24.30601579784778 -10.519071878391168 5.0064349625514355 1.0005335221241098 0.8635769370665493 0.4700414223528152 0.06828643409734804 0.00040822166013937346 3.9214548936800896e-05 0.0663741516711985 0.022039351835907973 3.026412496883156e-11 10.519071878391168 -0.1369565850575606 NNTQVLINCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNTQVLINCR 10 0 P62316;K7ERG4;P62316-2 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 17102600.0 8382800.0 3164400.0 5555400.0 False True 8116692.60251272 4427961.422128003 4100274.081572399 1.0 0.5455376517224787 0.5051656237792053 22.952460545751595 -13.999999999999998 0.3427046687945105 6.343906685054927 0.49903709613539277 0.9997405664245033 0.0036137101739275508 19.95489858251307 0.18795742319320366 77.35588277593017 0.01235447330322495 1.0000000000000041e-14 13.999999999999998 -5.844869588919535 NNTQVLINCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NNTQVLINCR 10 0 P62316;K7ERG4;P62316-2 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 115721800.0 9564800.0 89263000.0 16894000.0 False True 14510500.880544903 73333320.23499784 13554893.495096743 1.0 5.05381039832472 0.9341437354013465 23.790593984126616 -6.649876603812539 2.0089810968224455 3.6308191003034946 0.9514777346653241 0.19350155584650386 1.730273076885051 0.5088676534665866 3.936527326190807 0.6985292255202974 1.9164764566440955 2.2393573172764612e-07 6.649876603812539 -2.6793413656381704 NNTQVLINCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNTQVLINCR 10 0 P62316;K7ERG4;P62316-2 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 50797000.0 15821000.0 15246000.0 19730000.0 False True 21670451.24644893 14572381.308220046 15070180.352105007 1.0 0.6724539854982474 0.6954253135164645 24.369225859370673 -10.651987413256991 6.574927609025005 1.0016278427607408 0.683939649507356 0.9960538243970121 0.009378005393121773 0.00022479312513669112 1.1898337997159007e-05 0.00912143954254491 0.0030267382256836646 2.2284997348180436e-11 10.651987413256991 -0.3176881932533848 NNTQVLINCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NNTQVLINCR 10 0 P62316;K7ERG4;P62316-2 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 15034100.0 8382800.0 2311100.0 4340200.0 False True 6970669.621006623 2298649.6455825698 5247715.753182565 1.0 0.3297602340319531 0.752828069396402 22.73286582118587 -10.385694742018982 5.990934797776483 1.0000957792717808 0.5412941517145754 0.6105049646984742 0.17271672053778428 0.0002209999723096138 2.2661456009557956e-05 0.16726686962624587 0.05574408185453309 4.114388126255294e-11 10.385694742018982 -0.45880162755720544 NNTQVLINCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NNTQVLINCR 10 0 P62316;K7ERG4;P62316-2 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 34638800.0 9564800.0 13730000.0 11344000.0 False True 12381822.150395114 12965913.430360008 9279508.399269352 1.0 1.0471732894294767 0.7494461062803455 23.561720306219065 -6.866366711145115 1.1532131989677858 1.0261722250061653 0.7331777128060543 0.9609166912808662 0.02583046756429422 0.1403822857503419 0.3512246396592223 0.017419496927995146 0.04099849975034864 1.3602955860890945e-07 6.866366711145115 -0.2929945122001111 NNTVTPGGK(ub)PNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNTVTPGGKPNK 12 1 P18077;C9K025 P18077 RPL35A 60S ribosomal protein L35a 1 6125700.0 0.0 2230900.0 3894800.0 True False 0.0 1898058.4159800927 3491803.457559702 0.0 NNTVTPGGK(ub)PNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNTVTPGGKPNK 12 1 P18077;C9K025 P18077 RPL35A 60S ribosomal protein L35a 1 4447000.0 1121800.0 1945200.0 1380000.0 True False 1086189.073042274 2721928.5040839915 1018536.6008874078 1.0 2.5059435522217366 0.9377157496480972 20.050843824398413 -6.655328682406584 1.989092316707016 1.9730216962937313 0.9442341749065891 0.21615355843871087 0.6419106170861778 0.4955727643688243 3.7639694625325726 0.26115751361343104 0.7114473567925144 2.211420430659609e-07 6.655328682406584 -1.0287875213871422 NNTVTPGGK(ub)PNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNTVTPGGKPNK 12 1 P18077;C9K025 P18077 RPL35A 60S ribosomal protein L35a 1 20631800.0 0.0 1723300.0 18908500.0 True False 0.0 1647158.9078089702 14442701.732781406 0.0 NNTVTPGGK(ub)PNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NNTVTPGGKPNK 12 1 P18077;C9K025 P18077 RPL35A 60S ribosomal protein L35a 1 5126500.0 1121800.0 1934500.0 2070200.0 True False 932826.4041662969 1924078.4645318165 2503069.248476693 1.0 2.0626329357083755 2.68331732174089 19.83124909983269 -8.864405330803718 0.18293506794928346 9.585670430647268e-22 3.4693078415458465 0.9997077761462138 0.0118817674299413 0.3734591605886357 0.0569308108173916 0.5796047463066399 0.3635863649873514 1.3664529079347948e-09 8.864405330803718 3.4693078415458465 NNTVTPGGK(ub)PNK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNTVTPGGKPNKTR 14 2 P18077;C9K025 P18077 RPL35A 60S ribosomal protein L35a 2 2640980.0 943120.0 709870.0 987990.0 True False 913181.1718377868 993324.7929231472 729205.7799353276 1.0 1.0877631115894237 0.7985335248073427 19.800541588515106 -6.825300430716724 1.3487427598506503 1.0470679669145815 0.791469840858968 0.8961502468678821 0.039019141581385655 0.18668331487514395 0.6657846800948366 0.02272471888504855 0.05231889553779296 1.495200967132957e-07 6.825300430716724 -0.2555981260556135 NNTVTPGGK(ub)PNK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NNTVTPGGKPNKTR 14 2 P18077;C9K025 P18077 RPL35A 60S ribosomal protein L35a 2 3445830.0 943120.0 829110.0 1673600.0 True False 784246.0673001586 824643.4198645509 2023542.0221479053 1.0 1.0515110680802826 2.580238660442558 19.580946863949382 -6.9140590448130395 0.8676275848920283 0.9585248604104161 2.795970859121202 0.9923654880038453 0.06405442731301526 0.10179490438458567 0.12465730603859716 0.05351829801159483 0.15224115457547113 1.2188238815983073e-07 6.9140590448130395 1.8374459987107858 up NNTVTPGGKPNK(ub)TR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNTVTPGGKPNKTR 14 2 P18077;C9K025 P18077 RPL35A 60S ribosomal protein L35a 1 16712000.0 1392300.0 4030700.0 11289000.0 True False 1825318.7830523774 3429335.2715455405 10120922.571734501 1.0 1.8787596464716465 5.544742466743181 20.799717014996943 -6.943909524240916 0.6221291315740115 0.9599294175659081 6.65850086782187 0.998632443994637 0.0727871037817666 0.08602746890188015 0.046821414267298404 0.07316041381420697 0.3105042833035584 1.137864310281812e-07 6.943909524240916 5.698571450255962 NNTVTPGGKPNK(ub)TR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNTVTPGGKPNKTR 14 2 P18077;C9K025 P18077 RPL35A 60S ribosomal protein L35a 1 17246400.0 1392300.0 3026100.0 12828000.0 True False 1907070.9354927493 2892396.8960254933 9798290.600953003 1.0 1.516669800894509 5.13787422302743 20.862927076519835 -6.932642627833151 0.7247712947917573 0.9499696406238771 5.93392464732753 0.9970326253158787 0.10028352953619198 0.09128868274253789 0.07112676438843687 0.09284391016526715 0.3230272347566816 1.1677701563033148e-07 6.932642627833151 4.9839550067036535 up NNTVTPGGKPNK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NNTVTPGGKPNKTR 14 2 P18077;C9K025 P18077 RPL35A 60S ribosomal protein L35a 1 5693960.0 1020200.0 961760.0 3712000.0 True False 848341.5025231385 956578.8079855872 4488162.037651178 1.0 1.1275869507038487 5.290513341976645 19.69428561754785 -6.913438396379703 0.87198942010421 0.8846976480223228 5.870034503405273 0.9921557980458653 0.1765305751428943 0.10218802183558551 0.1267576718886047 0.14703144276280483 0.41622761757319177 1.220566942929909e-07 6.913438396379703 4.9853368553829505 up NNVSLLQSCIDLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NNVSLLQSCIDLFK 14 0 Q9Y5X3 Q9Y5X3 SNX5 Sorting nexin-5 0 6827200.0 2484500.0 2373400.0 1969300.0 False True 3257203.559932225 2019297.9714407404 1765535.7268594857 1.0 0.6199483496459022 0.5420403405478971 21.63520245354307 -13.999999999999998 0.22276912444136315 3.321633519793048 0.5014570419397167 0.9995008177040479 0.004469938055690533 13.07642117582881 0.14949940449205193 13.374810216266027 0.04234219691152015 1.0000000000000041e-14 13.999999999999998 -2.820176477853331 NNVSLLQSCIDLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NNVSLLQSCIDLFK 14 0 Q9Y5X3 Q9Y5X3 SNX5 Sorting nexin-5 0 9473800.0 5588700.0 2137100.0 1748000.0 False True 5411289.777599721 2990455.174829275 1290146.3611240517 1.0 0.552632606593792 0.23841753336970992 22.367541069841025 -8.149382003549103 0.2652528418504058 1.1744482475533966 4.1834659479869375e-20 0.9994062135239624 0.007614786127543219 0.08899463509957614 0.05582114806992135 0.0809188781337764 0.09900014975314422 7.0895390084137664e-09 8.149382003549103 -1.1744482475533966 down NNVSLLQSCIDLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NNVSLLQSCIDLFK 14 0 Q9Y5X3 Q9Y5X3 SNX5 Sorting nexin-5 0 29194200.0 4050200.0 14461000.0 10683000.0 False True 6144449.509282256 11880321.565691294 8571500.367474768 1.0 1.933504628485271 1.3949989099147178 22.550852332435724 -10.297217364172477 4.996181438260276 0.9997953069206231 1.6642517692002552 0.6698282441041961 0.21984403901234628 0.0005014053237350925 7.052970966347037e-05 0.21292746554602768 0.07095435848801993 5.044087780329861e-11 10.297217364172477 0.6644564622796321 NNVSLLQSCIDLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNVSLLQSCIDLFK 14 0 Q9Y5X3 Q9Y5X3 SNX5 Sorting nexin-5 0 14791400.0 2484500.0 3905100.0 8401800.0 False True 3403086.7910879413 3732559.769561201 6417467.880502575 1.0 1.0968159199865513 1.8857784930166177 21.69841251506596 -6.929753173408124 0.7488117955660547 0.9878923649403479 2.0467371481126855 0.9964896454357637 0.02350461448089137 0.09276581832551423 0.07830824536376035 0.021382626256671974 0.0714843952384483 1.1755654850998948e-07 6.929753173408124 1.0588447831723375 NNVSLLQSCIDLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NNVSLLQSCIDLFK 14 0 Q9Y5X3 Q9Y5X3 SNX5 Sorting nexin-5 0 20010700.0 4050200.0 9837700.0 6122800.0 False True 5243063.741377786 9290223.346966691 5008513.225233291 1.0 1.771907381870849 0.9552646071621363 22.321978654528174 -6.65891285067608 1.976968588820229 1.4973149162510286 0.9586897474402248 0.23093736852350144 0.3287468092292274 0.48700283351031914 3.6579383981708524 0.1344083675195397 0.3643397408937139 2.1932450068938278e-07 6.65891285067608 -0.5386251688108038 NNVVITVTQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NNVVITVTQR 10 0 Q6YHK3;Q6YHK3-2;Q6YHK3-4;Q6YHK3-3 Q6YHK3 CD109 CD109 antigen 0 5787900.0 2238100.0 1764500.0 1785300.0 False True 3065586.052378313 1686538.5555787901 1363648.9094076543 1.0 0.5501520840592148 0.44482486745062055 21.547731471637466 -13.999999999999886 0.20396295669423806 3.5392459436247092 0.37903090642280385 0.9994875271068865 0.0054502264277303735 12.61206217567308 0.1431830782232315 12.797909855677487 0.06513792532714031 1.0000000000002617e-14 13.999999999999886 -3.1602150372019056 NPAK(ub)VWTDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPAKVWTDLR 10 1 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 21952200.0 5949900.0 8270800.0 7731500.0 True False 7702262.840063136 7810522.709382486 6324446.331889199 1.0 1.014055592696245 0.8211153609290951 22.876850925331766 -6.889380276063122 1.026067579682792 1.0105214883305882 0.8047223836827055 0.9804977281770872 0.01226517181105951 0.11964635142586509 0.2248090427052099 0.009115504212016796 0.022674441270796365 1.290089153632045e-07 6.889380276063122 -0.20579910464788265 NPDDITNEEYGEFYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPDDITNEEYGEFYK 15 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 87241900.0 7241900.0 45071000.0 34929000.0 False True 9494201.030659355 38346582.48538198 31314882.1426268 1.0 4.0389478126227205 3.298316734762887 23.178615167107612 -9.881578382408689 7.182738996479932 0.9999999797697782 3.668632273692813 0.9453868512578669 0.3023613714007187 1.2008109624622076e-07 1.700591490947485e-08 0.2927601389927898 0.09758671299761329 1.3134744148592248e-10 9.881578382408689 2.668632293923035 NPDDITNEEYGEFYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPDDITNEEYGEFYK 15 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 120547000.0 33148000.0 8786000.0 78613000.0 False True 32095734.884297866 12294295.618384706 58021896.96055202 1.0 0.3830507593206542 1.807775929409797 24.935878258440756 -6.789007150963655 1.500274947380301 0.6547520027718136 1.8225256616819603 0.798128698886226 0.2621123094255119 0.23681688724322222 1.0530406724860584 0.1375251439255387 0.3222175598727302 1.625521990168936e-07 6.789007150963655 1.1677736589101468 NPDDITNEEYGEFYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPDDITNEEYGEFYK 15 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 331252200.0 2151200.0 322980000.0 6121000.0 False True 3263527.6737859817 265341695.5457419 4911181.667070391 1.0 81.30517711771752 1.50486901230195 21.638000842321393 -3.0634738418139484 1.0993817809606028e-15 8.872301044525994 65.8567404724867 0.0 38.89761892726928 0.0 0.2524014659894691 2435803820.1112323 2435803824.3250656 0.0008640247005770706 3.0634738418139484 56.98443942796071 NPDDITNEEYGEFYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPDDITNEEYGEFYK 15 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 119960900.0 7241900.0 69472000.0 43247000.0 False True 9919426.13498883 66402497.326817594 33032949.299923167 1.0 6.694187387775973 3.3301270507379375 23.241825228630503 -9.39629952283709 9.308127863807332 0.9999279042669946 5.012157219257081 0.6547631418929611 1.3733718822440126 0.0 0.0 1.3297616067350564 0.44325386891168533 4.015138005750935e-10 9.39629952283709 4.012229314990087 NPDDITNEEYGEFYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPDDITNEEYGEFYK 15 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 45153400.0 33148000.0 7074200.0 4931200.0 False True 27564030.705388173 7036089.8804812385 5962291.1207073005 1.0 0.25526346112746984 0.21630693944705995 24.716283533875032 -13.492227657082665 0.42513617510721574 9.999939798134049 0.21524934490886286 0.9998625368726587 0.004227899738106005 19.644338102143486 0.21764287858618034 161.96250491327723 0.009333717846136071 3.2193807501256806e-14 13.492227657082665 -9.784690453225187 NPDDITNEEYGEFYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPDDITNEEYGEFYK 15 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 17735100.0 2151200.0 8680500.0 6903400.0 False True 2784770.806491504 8197422.544227248 5647052.034865667 1.0 2.943661476599244 2.027833680855163 21.409127164413842 -10.079687364248024 5.931202084089895 0.9999948314443696 2.4857475787272825 0.7782284048800467 0.37388513197208945 2.555538151526062e-05 3.964524492331702e-06 0.36201397743518643 0.12067090746016443 8.323627488069104e-11 10.079687364248024 1.4857527472829128 NPDDITQEEYGEFYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPDDITQEEYGEFYK 15 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 292379000.0 21573000.0 173950000.0 96856000.0 False True 28282411.913229205 147997338.0517892 86834270.2283565 1.0 5.232840059958354 3.070256896574632 24.753401822084406 -9.315850509672531 8.882690623856202 0.9999616135014532 4.151548478267215 0.7390165005669157 0.8828708797181437 0.0 0.0 0.8548360533730899 0.28494535112436326 4.832251063591774e-10 9.315850509672531 3.151586864765762 NPDDITQEEYGEFYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPDDITQEEYGEFYK 15 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 483595200.0 5753200.0 471150000.0 6692000.0 False True 8728025.015259178 387069601.38824785 5369323.2667922 1.0 44.34790238473599 0.6151819291769935 23.05722380587784 -6.243771401510304 23.215984701792966 9.999999999999998 0.6151603667905505 0.0024802256837911374 20.50023087862958 1084.5298674484811 4041837.160371375 8.69138760150105 53.07675171667641 5.704644672083785e-07 6.243771401510304 -9.384839633209447 NPDDITQEEYGEFYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPDDITQEEYGEFYK 15 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 229939000.0 21573000.0 124320000.0 84046000.0 False True 29549121.088404197 118827131.32873636 64196065.78170387 1.0 4.021342325994497 2.172520312521105 24.816611883607298 -9.889253384358978 6.300437622303579 0.9999997896666167 3.0969313192581 0.6317041699337146 0.7547784263735394 2.2332109738218515e-06 3.9408457587970647e-07 0.7308111341874385 0.2436036896182893 1.290466145593571e-10 9.889253384358978 2.096931529591483 NPDDITQEEYGEFYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPDDITQEEYGEFYK 15 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 82204000.0 56627000.0 13175000.0 12402000.0 False True 47087859.501448534 13104023.65996727 14995200.859630933 1.0 0.2782887945790817 0.3184515290861681 25.48885180696296 -9.994258538743019 5.998784119482719 1.0000006499532859 0.2983701618325375 0.9975485344137531 0.016396367703183836 1.4251883283674367e-07 2.3917830330203306e-08 0.015875729547144987 0.005291904921014684 1.0133079763542686e-10 9.994258538743019 -0.7016304881207484 NPDDITQEEYGEFYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPDDITQEEYGEFYK 15 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 34753200.0 5753200.0 15265000.0 13735000.0 False True 7447630.812526473 14415489.330986544 11235370.933001125 1.0 1.935580548211459 1.508583228119189 22.82835012797029 -10.17541027076264 4.639402159569933 0.9998923097549323 1.722081888150561 0.792227307723309 0.17432092598418006 0.0001945632850614055 3.4580018415704e-05 0.1688104973245999 0.05626183693264473 6.677128423329264e-11 10.17541027076264 0.7221895783956288 NPDGGFATYETK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPDGGFATYETKR 13 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 63505400.0 21754800.0 19284800.0 22465800.0 True False 28520753.473782886 16407583.011561617 20141254.523170587 1.0 0.5752857485565361 0.7061964383824929 24.76550876024758 -10.740158425479075 10.251400877564699 1.0007792331117682 0.6407410934695158 0.9094335441578503 0.053444065324891876 0.0009535562704722503 2.4169675494635286e-05 0.051841695638755604 0.017248997913077286 1.8190371743660756e-11 10.740158425479075 -0.3600381396422524 NPDGGFATYETK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPDGGFATYETKR 13 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 90975000.0 2712600.0 24369600.0 63892800.0 True False 2626489.99780217 34100508.36578511 47157358.93708621 1.0 12.98330029595399 17.954516855783645 21.324704659756765 -8.675333054432876 0.47551302704186404 3.950506853481458e-15 18.370954837909764 0.9955258495763817 0.4759989653683884 0.289133154804459 0.17013092471687064 1.7814691937475386 1.0713796323774203 2.1118688556445276e-09 8.675333054432876 18.37095483790976 NPDGGFATYETK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPDGGFATYETKR 13 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 223007200.0 51787600.0 9106600.0 162113000.0 True False 78565575.38069876 7481456.079809453 130071294.49334797 1.0 0.09522562577257503 1.6555761714093251 26.227393977884937 -6.749522096124305 1.651908318064349 0.4676732090154674 1.6585125743047198 0.6468087388665439 0.38018057365142405 0.30087018857051206 1.6152517183787387 0.1818288903332413 0.44160208836610776 1.7802373312670887e-07 6.749522096124305 1.1908393652892524 NPDGGFATYETK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPDGGFATYETKR 13 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 53423200.0 21754800.0 2128300.0 29540100.0 True False 29798137.46136444 2034264.6686530681 22563336.777456492 1.0 0.06826818190535054 0.7572062786377699 24.828718821770472 -10.586729072176032 8.70879798445868 1.0001478221265143 0.4127372305697441 0.49208165327191056 0.2812578002264377 0.0008074393358949355 3.831603852800691e-05 0.2723928467148112 0.09077556468899385 2.589828035054467e-11 10.586729072176032 -0.5874105915567702 NPDGGFATYETK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPDGGFATYETKR 13 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 104947900.0 2712600.0 40689500.0 61545800.0 True False 2255647.0885554454 40470297.58726666 74414742.22437292 1.0 17.941768369973392 32.99041884784795 21.10510993519104 -7.758695826792898 0.39809766232015126 6.66017837820607e-18 38.82377753950432 0.9968166374758962 0.737293976285213 0.14422299291002233 0.08464684605691103 1.4580589445546348 3.5772881054707875 1.7430272355743986e-08 7.758695826792898 38.82377753950432 NPDGGFATYETK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPDGGFATYETKR 13 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 216906300.0 51787600.0 54578700.0 110540000.0 True False 67040069.08621218 51541347.36646687 90422854.2361808 1.0 0.7688140550718368 1.348788201872209 25.998520299977386 -6.798539445790908 1.4618356568105777 0.8722035224030463 1.3565105487731575 0.8278470899720497 0.09891133881037487 0.2228617222192397 0.9403694426877479 0.05323290023372344 0.12391368868899555 1.590232240777779e-07 6.798539445790908 0.48430702637011114 NPDMEKDCPTIIHFVLANINFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPDMEKDCPTIIHFVLANINFR 22 1 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 0 21724100.0 3118800.0 7372300.0 11233000.0 False True 4731447.614821369 6056655.464957186 9012792.626401195 1.0 1.2800850729033908 1.9048700017661433 22.173850221641878 -6.957855368434878 0.46467810148811556 0.9826149335725274 2.2277247698237312 0.9996821851557708 0.006743029748656518 0.08047637938962361 0.02403123243629352 0.008554784946421529 0.051589250055475065 1.1019062123974655e-07 6.957855368434878 1.2451098362512039 NPDMEKDCPTIIHFVLANINFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPDMEKDCPTIIHFVLANINFR 22 1 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 0 14130800.0 3118800.0 4795700.0 6216300.0 False True 4037348.080738988 4528815.079240894 5084997.18462431 1.0 1.1217301527323225 1.2594894180373872 21.944976543734327 -6.969517076572327 0.2694743815370198 0.9655350928813059 1.419823006377579 0.9999783629514821 0.0004930480906784893 0.07645974607117002 0.00958966352076634 0.0027091084364644835 0.01282165924452491 1.0727114677115098e-07 6.969517076572327 0.45428791349627307 NPDTQWITK(ub)PVHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPDTQWITKPVHK 13 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 258165000.0 38201000.0 43344000.0 176620000.0 True False 50081880.93901026 36877244.153588735 158345056.65867203 1.0 0.7363390404305673 3.1617234354976547 25.577785411195 -6.879971207387605 1.0799980359557777 0.8366655124242196 3.3334879210204296 0.9736605480132375 0.17633872703276693 0.12765382737763714 0.2724611649416473 0.12578251344573935 0.3041423854814733 1.3183441385007173e-07 6.879971207387605 2.49682240859621 up NPDTQWITK(ub)PVHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPDTQWITKPVHK 13 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 257443000.0 29845000.0 30618000.0 196980000.0 True False 28897586.81132707 42843927.070760705 145385028.72666794 1.0 1.482612626116138 5.031043930273131 24.784445684941158 -6.931701480834058 0.732691091464012 0.9493006841536932 5.792121233348321 0.996862209714221 0.10067927247059612 0.09176393057476843 0.07342226509308149 0.09267000938820653 0.3181210388365243 1.1703035412237138e-07 6.931701480834058 4.842820549194628 up NPDTQWITK(ub)PVHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPDTQWITKPVHK 13 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 468921000.0 76091000.0 120850000.0 271980000.0 True False 115435609.99723391 99283373.29464029 218223033.78693122 1.0 0.8600757885458338 1.890430810667179 26.782513099559978 -6.872615746409236 1.1201131652844802 0.9194555518830522 1.9538648774505827 0.9672273695872342 0.08260914796055444 0.1343742268640536 0.3135017124503231 0.05713875675110552 0.13593289168198677 1.3408625265211438e-07 6.872615746409236 1.0344093255675304 NPDTQWITK(ub)PVHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPDTQWITKPVHK 13 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 295327000.0 38201000.0 29386000.0 227740000.0 True False 52324942.0432081 28087629.35349297 173952502.45252892 1.0 0.5367923643431691 3.3244662231806212 25.64099547271789 -6.864214886072359 1.1643376658389821 0.7452970058218947 3.470686491046486 0.9585561855804263 0.2483018299547874 0.14251811185529825 0.36478396156387627 0.16602817244546522 0.38956701005467603 1.3670522497049138e-07 6.864214886072359 2.725389485224591 up NPDTQWITK(ub)PVHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPDTQWITKPVHK 13 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 218692000.0 29845000.0 53237000.0 135610000.0 True False 24817439.85767799 52950201.71428283 163965424.01020402 1.0 2.133588396625092 6.60686295405594 24.564850960375434 -6.945186309662214 0.60940609439678 0.9504778235965443 8.02269033690742 0.9987673154574243 0.08498501112984923 0.08547821617603343 0.044419533881499676 0.0864339395654881 0.37711943910463513 1.1345240074380287e-07 6.945186309662214 7.072212513310876 NPDTQWITK(ub)PVHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPDTQWITKPVHK 13 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 397627000.0 76091000.0 94046000.0 227490000.0 True False 98501299.47784743 88812257.42692193 186089154.2445159 1.0 0.9016353885452595 1.8892050686739077 26.553639421652427 -6.88239343002848 1.0663248916345647 0.9368642632930386 1.9624972129349123 0.9755667935029778 0.06943017917365593 0.125532687728405 0.25963466528058166 0.05004277032636825 0.1217905225512294 1.3110117073780036e-07 6.88239343002848 1.0256329496418737 NPDTQWITK(ub)PVHK(ub)HR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPDTQWITKPVHKHR 15 2 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 2 23776200.0 3754300.0 3055900.0 16966000.0 True False 4921923.656692919 2599971.631804906 15210521.069363771 1.0 0.5282429824504528 3.090361031642625 22.23079084984176 -6.859172869916438 1.1898646862809275 0.7445715546348967 3.2125079227874878 0.9526271253865568 0.24233145807307763 0.14766228267587148 0.39771244468384875 0.15889534643518205 0.37058127577655803 1.3830157631599963e-07 6.859172869916438 2.467936368152591 up NPDTQWITK(ub)PVHK(ub)HR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPDTQWITKPVHKHR 15 2 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 2 40335500.0 3016800.0 3378700.0 33940000.0 True False 2921033.3353128326 4727832.529687738 25050095.82182512 1.0 1.6185479544283952 8.575765130438795 21.478047391858293 -6.924349950087678 0.7918012203024356 0.8691970625280273 9.818154622228992 0.9953063568438635 0.2353154351973719 0.09567931124755692 0.09284464387815174 0.20756875756165172 0.6501560210703398 1.1902825039334919e-07 6.924349950087678 8.948957559700965 up NPDTQWITK(ub)PVHK(ub)HR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPDTQWITKPVHKHR 15 2 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 2 28371100.0 3016800.0 8537300.0 16817000.0 True False 2508602.8669004166 8491307.87037862 20333356.94697737 1.0 3.3848752954947883 8.105450733260499 21.25845266729257 -6.960247049246215 0.43193832403533766 0.8163011952539415 10.855631545356646 0.9997792515944267 0.04386807897955637 0.07961299678574305 0.020806136997250826 0.06167303615319963 0.39178071863257075 1.0958546397977386e-07 6.960247049246215 10.039330350102704 NPDTQWITKPVHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPDTQWITKPVHK 13 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 20337200.0 3574300.0 1981900.0 14781000.0 False True 3460835.802972902 2773283.0054719625 10909412.679504914 1.0 0.8013333088757568 3.1522479830258314 21.722689064755276 -6.88636776209551 1.0436592249954963 0.8624651869733705 3.340604329289612 0.9784686734095263 0.15619999086030353 0.12213847266336174 0.23947406865378387 0.11454870416774057 0.28207430727234994 1.2990690558882337e-07 6.88636776209551 2.4781391423162415 up NPDTQWITKPVHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPDTQWITKPVHK 13 1 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 7052300.0 3574300.0 1364900.0 2113100.0 False True 2972188.818338025 1357547.0127885633 2554939.4401295045 1.0 0.45674992262021574 0.8596154538923823 21.503094340189552 -9.758434709540335 6.059219622870745 1.0000000102536233 0.6581826882554382 0.48975874092264016 0.16446916443176807 221226132.30284062 71.55504250261008 31.754826019918983 0.056302169607828995 1.7440755365611423e-10 9.758434709540335 -0.34181732199818504 NPDTQWITKPVHK(ub)HR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPDTQWITKPVHKHR 15 2 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 109267700.0 7809800.0 10732000.0 90725900.0 True False 7561882.173868393 15017343.566640643 66962065.07134131 1.0 1.9859266808647322 8.855211378820767 22.850313939344893 -6.93276065824358 0.7237725915784581 0.9054857265620405 10.369987285239741 0.9970535270420771 0.1896516518982441 0.09122963839509231 0.07084216202648849 0.17571101879527926 0.6123907888364732 1.1674528286176765e-07 6.93276065824358 9.4645015586777 NPDTQWITKPVHK(ub)HR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPDTQWITKPVHKHR 15 2 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 143334600.0 24750000.0 33089000.0 85495600.0 True False 37547559.467368476 27184009.424463026 68597357.18594727 1.0 0.7239887175113973 1.8269458297432966 25.16221580207758 -6.8404249259779295 1.2803462158955004 0.8531711506897262 1.8635453559861432 0.9251914334358016 0.1281760189484493 0.16830524178230535 0.5357442538710785 0.07849212582798702 0.1808591708883072 1.444026203330338e-07 6.8404249259779295 1.010374205296417 NPDTQWITKPVHK(ub)HR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPDTQWITKPVHKHR 15 2 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 71319400.0 7809800.0 17653000.0 45856600.0 True False 6494194.7328026 17557899.785153855 55445003.0430375 1.0 2.7036300122735404 8.537625575497634 22.63071921477917 -6.948444307429557 0.575669316273989 0.9290727291155528 10.598603012795639 0.9990734788135223 0.09824275537754608 0.08411651035582413 0.038594505825413294 0.10342153779771174 0.48678443753845624 1.1260448601190109e-07 6.948444307429557 9.669530283680086 NPDTQWITKPVHK(ub)HR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPDTQWITKPVHKHR 15 2 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 153899500.0 24750000.0 40344700.0 88804800.0 True False 32039362.895437308 38099481.97915842 72643237.61419572 1.0 1.1891460546047288 2.267312176314866 24.93334212417003 -6.936930084683936 0.6875366314835807 0.9870176110971127 2.533548376921245 0.9977334351993593 0.026575101391834135 0.08919556832647382 0.06120067092136026 0.0253025125108911 0.09411914082859214 1.1562983750185109e-07 6.936930084683936 1.5465307658241323 up NPENK(ub)EEAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPENKEEAER 10 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q7Z6W7;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJB7 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily B member 7 1 4879960.0 903960.0 1907400.0 2068600.0 True False 875264.2846026875 2669034.7669595946 1526771.6033302112 1.0 3.0494044072313096 1.7443549681948525 19.73935917654308 -10.074614239378388 4.813291962130858 0.9999703801004735 2.396879687698117 0.6043640150685906 0.5327842026349886 184965852.34283894 10.68930401275785 100635.57879902904 0.18238620376315806 8.421428400879605e-11 10.074614239378388 1.3969093075976433 NPENK(ub)EEAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPENKEEAER 10 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q7Z6W7;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJB7 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily B member 7 1 3231430.0 903960.0 880170.0 1447300.0 True False 751682.7922180125 875428.3495099343 1749923.7384408838 1.0 1.1646247041611557 2.328008245708715 19.519764451977355 -6.932479151058736 0.7261574523176069 0.9838337946072653 2.582654566404643 0.997003415133608 0.032355262875062005 0.09137077842223133 0.07152346014068975 0.02992452261194194 0.10386833055706145 1.1682098101343157e-07 6.932479151058736 1.5988207717973777 up NPENWAYYK(ub)GLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPENWAYYKGLEK 13 1 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 80068000.0 19561000.0 31847000.0 28660000.0 True False 25644660.42899343 27095551.738633737 25694538.12613258 1.0 1.0565767409421398 1.0019449544780386 24.612155132362382 -6.638029704824793 2.051880745232743 1.0370533039159324 1.0021723558334588 0.14704033995263754 0.024219504257272494 0.5383094716924395 4.3292325817109 0.009621078337947864 0.026814351253441695 2.3012844090349634e-07 6.638029704824793 -0.03488094808247366 NPENWAYYK(ub)GLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPENWAYYKGLEK 13 1 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 85205000.0 25673000.0 33123000.0 26409000.0 True False 24858024.6676897 46349186.63416313 19491690.646982323 1.0 1.8645563054093957 0.7841206575161822 24.567208322011655 -6.693614888742534 1.8535944443151386 1.5401716624795057 0.7876845013368423 0.3874103319281281 0.36538184282968555 0.4089313661306248 2.7267972371267253 0.15753260786303608 0.4083629531364957 2.0248138894628809e-07 6.693614888742534 -0.7524871611426633 NPENWAYYK(ub)GLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPENWAYYKGLEK 13 1 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 170780000.0 61514000.0 48194000.0 61072000.0 True False 93321235.27578616 39593404.1585593 49001092.43119145 1.0 0.4242700393061825 0.5250797665331124 26.47570206834522 -10.087392951643851 5.416911911170196 1.0000059829582846 0.4746749029196774 0.9731231928142238 0.04115539880357962 114447821.4970081 20.303410242937698 8540.57058485259 0.01408858767973618 8.177245723574947e-11 10.087392951643851 -0.5253310800386072 NPENWAYYK(ub)GLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPENWAYYKGLEK 13 1 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 68688000.0 19561000.0 20060000.0 29067000.0 True False 26793230.31614858 19173682.870450843 22201973.253656138 1.0 0.7156166928813601 0.8286411526972454 24.675365193885273 -10.048084300360618 5.622434510350627 1.0000010129901646 0.7721289229169356 0.8442285766453752 0.04614204250072079 5.85899039460392e-07 9.922612770976053e-08 0.04467703925646104 0.014892280180399243 8.951909842776321e-11 10.048084300360618 -0.22787209007322906 NPENWAYYK(ub)GLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPENWAYYKGLEK 13 1 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 74349000.0 25673000.0 27298000.0 21378000.0 True False 21348237.00674037 27150940.255771253 25848040.95929608 1.0 1.2718118244236643 1.2107810565872474 24.347613597445932 -10.050994472513421 4.487525347402246 0.9999868935121121 1.2412964404828284 0.9542169971466979 0.024915706696769582 17259333.95194019 0.0689453112006873 2371.9780764537873 0.008529309112040848 8.89212435244486e-11 10.050994472513421 0.24130954697071627 NPENWAYYK(ub)GLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPENWAYYKGLEK 13 1 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 142067000.0 61514000.0 42651000.0 37902000.0 True False 79631085.62221953 40277434.35675782 31004224.907361377 1.0 0.5058003924226191 0.3893482634966142 26.24682839043767 -13.999999999999941 0.2030602797207822 3.7797575736119065 0.31595918775842846 0.9994873165959134 0.0059939223089121325 12.59304332742451 0.14287031017154136 13.921499904167426 0.07249344138143601 1.000000000000135e-14 13.999999999999941 -3.4637983858534778 NPESPFMFSLHLNEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPESPFMFSLHLNEAR 16 0 Q9HBM1 Q9HBM1 SPC25 Kinetochore protein Spc25 0 19350400.0 4450700.0 7997300.0 6902400.0 False True 6752037.289754216 6570119.331809899 5538137.614570614 1.0 0.973057323273323 0.8202172732331297 22.68689144102255 -6.937036938110824 0.6866115505405159 1.0018350820456 0.7823663958780999 0.9977489378493122 0.0037561387355795717 0.08914558644363432 0.06097092018863471 0.0035788371339415363 0.013335493045495016 1.1560139153934006e-07 6.937036938110824 -0.21946868616750004 NPESPFMFSLHLNEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPESPFMFSLHLNEAR 16 0 Q9HBM1 Q9HBM1 SPC25 Kinetochore protein Spc25 0 15511600.0 4450700.0 6102700.0 4958200.0 False True 5761518.886413042 5763079.38029556 4055858.475428182 1.0 1.0002708476555022 0.7039564662354589 22.458017763115 -6.906689777468999 0.9179903824793809 1.0101623153041628 0.668256087702745 0.9896110765518514 0.014230931142439802 0.10664764585623918 0.15094549164852203 0.01146362773651999 0.03096369561667245 1.2396817921166726e-07 6.906689777468999 -0.34190622760141776 NPFDTFFGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPFDTFFGQR 10 0 P25685;M0R080;P25685-2;M0QXK0;M0QYT3;M0QZD0;M0R1D6;M0R128;A0A1B0GX60 P25685 DNAJB1 DnaJ homolog subfamily B member 1 0 10145500.0 2112700.0 2709600.0 5323200.0 False True 2769770.159415905 2305338.241938074 4772406.327740018 1.0 0.8323211346981328 1.7230333396134334 21.40133483309739 -6.858012186450588 1.1957170241223216 0.9094602012821399 1.7645612378297488 0.9511797920408771 0.08539264392497048 0.14886472286916902 0.40556500536601037 0.05574319136396 0.12984569898201467 1.3867169165785307e-07 6.858012186450588 0.8551010365476089 NPFDTFFGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPFDTFFGQR 10 0 P25685;M0R080;P25685-2;M0QXK0;M0QYT3;M0QZD0;M0R1D6;M0R128;A0A1B0GX60 P25685 DNAJB1 DnaJ homolog subfamily B member 1 0 7962100.0 2400100.0 1169400.0 4392600.0 False True 2323910.1392483157 1636347.51834044 3242046.2848246642 1.0 0.7041354528750099 1.3950824647089521 21.148122853140936 -6.790345317633437 1.4948174303719575 0.8347097064791048 1.4025125034024437 0.8024445394396176 0.12580591567429397 0.23485960301047104 1.0367101433828863 0.0662409603993263 0.1550564481103553 1.620521071002915e-07 6.790345317633437 0.5678027969233389 NPFDTFFGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPFDTFFGQR 10 0 P25685;M0R080;P25685-2;M0QXK0;M0QYT3;M0QZD0;M0R1D6;M0R128;A0A1B0GX60 P25685 DNAJB1 DnaJ homolog subfamily B member 1 0 8859000.0 2112700.0 3438100.0 3308200.0 False True 2893822.2835707376 3286193.373723688 2526871.2945176777 1.0 1.1355892144381434 0.8731950503193054 21.464544894620282 -6.7662706993483885 1.5888697148777993 1.07814019189794 0.8719273143841344 0.7160514013897818 0.05709255987359518 0.27249762626531276 1.3570602914143202 0.02833395391174803 0.0676761029140695 1.7128893165981167e-07 6.7662706993483885 -0.20621287751380568 NPFDTFFGQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPFDTFFGQR 10 0 P25685;M0R080;P25685-2;M0QXK0;M0QYT3;M0QZD0;M0R1D6;M0R128;A0A1B0GX60 P25685 DNAJB1 DnaJ homolog subfamily B member 1 0 5014340.0 2400100.0 1687500.0 926740.0 False True 1995789.4924581284 1678409.1025574773 1120517.0492383766 1.0 0.8409750171047613 0.5614404993475959 20.928528128575213 -6.962488463990758 0.39881595357979194 1.0155684888147023 0.37665965658660744 0.9998516483515627 0.002207980924664912 0.0788238790863645 0.017932536453960722 0.0035974204441345903 0.023430834819165233 1.0902134509511141e-07 6.962488463990758 -0.6389088322280949 NPFGNAGLLLGEAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPFGNAGLLLGEAGK 15 0 P49748-2;P49748;P49748-3;G3V1M7 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 15163800.0 3426700.0 3695600.0 8041500.0 False True 4492436.88421 3144230.8853359693 7209442.719514833 1.0 0.6998942815172986 1.6047955497949353 22.099066804283236 -6.817317146289882 1.383470495122665 0.8377941670502073 1.6234322725552064 0.8780971040297709 0.13139765168710335 0.19698950754426878 0.74157308763287 0.07464939745430904 0.1721877100445511 1.5229402109129395e-07 6.817317146289882 0.7856381055049991 NPFGNAGLLLGEAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPFGNAGLLLGEAGK 15 0 P49748-2;P49748;P49748-3;G3V1M7 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 11566200.0 3999400.0 1310400.0 6256400.0 False True 3872441.236160876 1833649.553645723 4617661.152023182 1.0 0.4735125575368566 1.192441891410369 21.884811915778002 -6.710382847110287 1.7936205567502461 0.6764609309008522 1.190789133930848 0.4670366989220087 0.22184488165971333 0.37429838119143244 2.3474665795379397 0.09841447536143035 0.24992356692809517 1.948126494952281e-07 6.710382847110287 0.5143282030299958 NPFGNAGLLLGEAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPFGNAGLLLGEAGK 15 0 P49748-2;P49748;P49748-3;G3V1M7 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 12029100.0 3426700.0 3233500.0 5368900.0 False True 4693643.593085545 3090633.2782454086 4100876.3959663697 1.0 0.6584720839900123 0.8737085197537341 22.162276865806128 -10.449342782255114 5.880396772451441 1.0001351964545122 0.7660903018718731 0.611608397466264 0.08786990694607484 0.00015583441700242314 1.4592772244643058e-05 0.08512856045715986 0.02835989051957855 3.5535073473810425e-11 10.449342782255114 -0.2340448945826391 NPGFEIIHGLLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPGFEIIHGLLDR 13 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 5069700.0 1087300.0 2275700.0 1706700.0 False True 1425460.8294281792 1936174.430609122 1530107.055822417 1.0 1.3582796458783188 1.073412207641101 20.442996964989973 -10.013416960055336 5.1596268744945455 0.9999982471551403 1.2158459267607433 0.43358575042249003 0.11629664467276667 2.344982232822266e-06 4.484623179622388e-07 0.11260465643497096 0.0375345806692677 9.695786413535334e-11 10.013416960055336 0.21584767960560303 NPGFEIIHGLLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPGFEIIHGLLDR 13 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 9118100.0 3470700.0 2572100.0 3075300.0 False True 3360524.528265128 3599152.9433243065 2269786.6729775732 1.0 1.0710092763948282 0.675426307377483 21.680255003300324 -6.860477850473999 1.183408850516042 1.0385724903760736 0.6561027386656451 0.9542139763482185 0.03684683552668005 0.14630447285085657 0.3890781748393072 0.02428116342499146 0.056706874019268445 1.378866274966662e-07 6.860477850473999 -0.3824697517104285 NPGFEIIHGLLDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPGFEIIHGLLDR 13 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 9792300.0 1087300.0 2527800.0 6177200.0 False True 1489304.1931776702 2416113.4376832345 4718272.583427419 1.0 1.6223102363849977 3.1681053508351606 20.506207026512865 -6.955599842162715 0.4935606136597217 0.9672377651055689 3.889123086820002 0.9995705816208407 0.01888840626707532 0.08131212214806308 0.027237372155702724 0.022429014950735078 0.12749516247987577 1.107643894224877e-07 6.955599842162715 2.921885321714433 NPGFEIIHGLLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPGFEIIHGLLDR 13 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 8793700.0 3470700.0 1528100.0 3794900.0 False True 2886040.828079842 1519867.8219958993 4588396.044364895 1.0 0.5266272767898114 1.5898583276168252 21.4606602787346 -6.785663478177418 1.5135326098988586 0.7339346937334634 1.5998673061925268 0.7870000640600148 0.20072840511466752 0.24187429265562352 1.0946160838690617 0.10441565020677594 0.24526556691938686 1.6380853331807433e-07 6.785663478177418 0.8659326124590634 NPGVWLNTTQPLCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPGVWLNTTQPLCK 14 0 A0A0A0MTS6;K7EIE8;O95983-2;O95983 A0A0A0MTS6 MBD3 Methyl-CpG-binding domain protein 3 0 4486000.0 0.0 1979500.0 2506500.0 False True 0.0 1684166.3160305666 2247151.424045753 0.0 NPGYIK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPGYIKLR 8 1 Q99623;J3KPX7;F5GY37;Q99623-2;U3KPZ5 Q99623 PHB2 Prohibitin-2 1 4333210.0 891460.0 774950.0 2666800.0 True False 863161.0902605323 1084391.5763108633 1968285.0777148856 1.0 1.2563026630215175 2.280321830911989 19.71927030664761 -6.9449012520797195 0.612268884662819 0.9887077602116768 2.601452619802742 0.998737956896515 0.0196499183720117 0.08560004691393623 0.044949741145639585 0.019931018407057573 0.0864174223034683 1.135268918653812e-07 6.9449012520797195 1.6127448595910652 up NPGYIK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPGYIKLR 8 1 Q99623;J3KPX7;F5GY37;Q99623-2;U3KPZ5 Q99623 PHB2 Prohibitin-2 1 3992960.0 891460.0 1713600.0 1387900.0 True False 741288.488374119 1704368.4966770308 1678103.473075452 1.0 2.299197307670664 2.2637657260212762 19.499675582081885 -10.55842541109629 6.424384065439006 0.9981341892371441 2.28148151684597 0.9994269813091653 0.014464882636793332 0.00038682581533899314 2.6588143591314935e-05 0.01401522884807134 0.004668520796428803 2.764232627888524e-11 10.55842541109629 1.2833473276088259 NPHAAK(ub)DSSDPNELYVNHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPHAAKDSSDPNELYVNHK 19 1 A0A2R8YEZ4;A0A2R8Y5D3;O15160-2;O15160;A0A2R8YEY5;E7EQB9;D6RDJ3 A0A2R8YEZ4 POLR1C DNA-directed RNA polymerases I and III subunit RPAC1 1 9865100.0 2521800.0 4530500.0 2812800.0 True False 3306104.221145938 3854567.0597506794 2521758.438282825 1.0 1.1658939954453815 0.7627583008888785 21.656700773978727 -6.794956367895142 1.47632045658074 1.0921264005598383 0.7578571949444508 0.817008875004736 0.0707694939633146 0.22805222163443872 0.9817110371776088 0.03772018826954 0.08801008535277069 1.6034064714497618e-07 6.794956367895142 -0.33426920561538753 NPHAAK(ub)DSSDPNELYVNHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPHAAKDSSDPNELYVNHK 19 1 A0A2R8YEZ4;A0A2R8Y5D3;O15160-2;O15160;A0A2R8YEY5;E7EQB9;D6RDJ3 A0A2R8YEZ4 POLR1C DNA-directed RNA polymerases I and III subunit RPAC1 1 70463500.0 7812500.0 10537000.0 52114000.0 True False 11852133.670255223 8656590.02404324 41813645.05762242 1.0 0.730382415933116 3.5279424128130006 23.49864346666006 -6.883248464877183 1.0614872055457203 0.8244681627782658 3.739004391376809 0.9762138385172398 0.19433448548097412 0.12479276217386351 0.25521239872041895 0.14058797862219186 0.3429735739409047 1.308433139150785e-07 6.883248464877183 2.914536228598543 up NPHAAK(ub)DSSDPNELYVNHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPHAAKDSSDPNELYVNHK 19 1 A0A2R8YEZ4;A0A2R8Y5D3;O15160-2;O15160;A0A2R8YEY5;E7EQB9;D6RDJ3 A0A2R8YEZ4 POLR1C DNA-directed RNA polymerases I and III subunit RPAC1 1 8704500.0 2521800.0 3029100.0 3153600.0 True False 3454177.609082539 2895264.3461058177 2408784.6304307287 1.0 0.8381920890497655 0.6973540167989577 21.71991083550162 -6.972750581504185 0.18078892901537202 1.107743546141405 0.4239910391194919 0.9999966481258664 0.00022631278233035533 0.07541984605833701 0.00570655026556188 0.00538581625570064 0.01576739511360498 1.0647543388651272e-07 6.972750581504185 -0.683752507021913 NPHAAK(ub)DSSDPNELYVNHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPHAAKDSSDPNELYVNHK 19 1 A0A2R8YEZ4;A0A2R8Y5D3;O15160-2;O15160;A0A2R8YEY5;E7EQB9;D6RDJ3 A0A2R8YEZ4 POLR1C DNA-directed RNA polymerases I and III subunit RPAC1 1 64025500.0 7812500.0 10725000.0 45488000.0 True False 10113435.25739816 10128144.321967302 37209650.74629453 1.0 1.0014544083384902 3.6792296385221825 23.26976978875251 -6.907011433585598 0.9158260465499972 0.9090522642497127 4.004068274265886 0.9897445438413489 0.12786842837025458 0.10642819573303358 0.1497249183688672 0.1031646461184307 0.27922254647069794 1.2387639734050407e-07 6.907011433585598 3.095016010016173 up NPHAPTIHFNYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPHAPTIHFNYR 12 0 P36551;P36551-2 P36551 CPOX Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial 0 25060800.0 9201000.0 5205800.0 10654000.0 False True 12062600.102610761 4429114.9320494635 9551626.280384395 1.0 0.36717746541981866 0.7918380945346182 23.524037578981137 -9.97978196596378 5.47909839265712 1.0000010811425857 0.579507779976647 0.5665903904510585 0.17336697586586478 2.2896117670493012e-06 4.2639502454674246e-07 0.16786228277491438 0.05595395085888287 1.047654382463706e-10 9.97978196596378 -0.42049330116593864 NPHAPTIHFNYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPHAPTIHFNYR 12 0 P36551;P36551-2 P36551 CPOX Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial 0 18756100.0 4791700.0 1647400.0 12317000.0 False True 4639590.10634397 2305215.41107751 9090808.19792045 1.0 0.4968575581548596 1.9593989963660974 22.145565922593804 -6.813828182699129 1.3983825828299983 0.7270071386380437 1.987289143868767 0.8695912910691896 0.21908783294232387 0.20162373776112777 0.7763113265307954 0.12316694620001468 0.2844486910583465 1.535224234154192e-07 6.813828182699129 1.2602820052307233 NPHAPTIHFNYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPHAPTIHFNYR 12 0 P36551;P36551-2 P36551 CPOX Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial 0 25414500.0 9201000.0 6714200.0 9499300.0 False True 12602858.347675662 6417544.443109729 7255760.984224576 1.0 0.5092134074722273 0.5757234417827723 23.587247640504028 -10.477656300367927 6.127385064867851 1.0002882836999332 0.5424684246276537 0.9843985681701869 0.02715260780597302 0.00010699781981545038 9.121310500893187e-06 0.02630652653419938 0.0087634664865529 3.3292292348401986e-11 10.477656300367927 -0.4578198590722795 NPHAPTIHFNYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPHAPTIHFNYR 12 0 P36551;P36551-2 P36551 CPOX Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial 0 13361600.0 4791700.0 4618400.0 3951500.0 False True 3984510.858302412 4593519.7625193745 4777740.380328304 1.0 1.1528440819650392 1.1990782683834484 21.92597119802808 -13.999999999997929 0.16752590439602819 0.23406719630680042 1.2409551552935105 0.9995186145204732 0.0018664539065172995 12.06858875586318 0.12956141922807055 3.003369473969981 0.038561027114918094 1.0000000000047691e-14 13.999999999997929 1.0068879589867101 NPHAPTIHFNYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPHAPTIHFNYR 12 0 P36551;P36551-2 P36551 CPOX Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial 0 12102900.0 2465300.0 4466200.0 5171400.0 False True 3191379.448328144 4217652.043894669 4230258.263044918 1.0 1.3215764882186463 1.3255265729247607 21.605748721556555 NPHLNK(ub)DLAFTLEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPHLNKDLAFTLEER 15 1 P48163 P48163 ME1 NADP-dependent malic enzyme 1 74149500.0 2375500.0 12230000.0 59544000.0 True False 3603807.1723124767 10047460.94657387 47775102.300937645 1.0 2.788012916941573 13.256842005306712 21.781090388746726 -6.936354603424365 0.6926443545500881 0.871860441803789 15.800910354731613 0.997646410708772 0.26226564291089144 0.0894697105190937 0.062481640927651995 0.24872778218521538 0.9164319786741274 1.1578315953226712e-07 6.936354603424365 14.929049912927823 NPHLNK(ub)DLAFTLEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPHLNKDLAFTLEER 15 1 P48163 P48163 ME1 NADP-dependent malic enzyme 1 52008500.0 2375500.0 8492000.0 41141000.0 True False 3075131.5781055074 8019412.7349320585 33653760.14230787 1.0 2.607827512822254 10.943843958391172 21.552216710839176 -6.938999752295665 0.6688059656070048 0.9046176037382887 13.127151345087828 0.9980299025508242 0.1934472807924149 0.08822601080835588 0.056710406894631575 0.18690843178217187 0.7206842447286411 1.1508010453154892e-07 6.938999752295665 12.22253374134954 NPHPSSAFLNLIGFVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPHPSSAFLNLIGFVSR 17 0 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 69732100.0 21421000.0 22870040.0 25441060.0 False True 28083138.44125908 19457919.178717703 22808663.15907979 1.0 0.6928683992858359 0.8121835530166331 24.743200837768093 -10.114278707976716 4.680712772333991 1.0000171289744701 0.7525259761484008 0.8515432493378743 0.0487102075509348 67908897.18612516 1.0418934529033925 12947.139803569977 0.01667479965815611 7.686370100705942e-11 10.114278707976716 -0.24749115282606937 NPHPSSAFLNLIGFVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPHPSSAFLNLIGFVSR 17 0 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 225820000.0 67443000.0 57127000.0 101250000.0 False True 65302058.88143174 79938109.01336941 74729587.56510873 1.0 1.2241284636754286 1.1443680160344478 25.96062514283172 -10.109047267329712 4.180342736604416 0.9999732585024373 1.1842482397507295 0.8767702504135831 0.03256206683873383 4607361.127038495 5570839.39252148 1143.8194889660724 0.011146861592056873 7.779518764456947e-11 10.109047267329712 0.1842749812482921 NPHPSSAFLNLIGFVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPHPSSAFLNLIGFVSR 17 0 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 177022000.0 47765000.0 52470000.0 76787000.0 False True 72462997.08924669 43106318.550018884 61610015.793062314 1.0 0.5948735255447465 0.8502272645055289 26.11074114149561 -10.521824020502434 5.819764431787237 1.0004574172653975 0.7225503950251377 0.6115093409104249 0.10424772739429518 0.0006197055125786516 5.0917560861962146e-05 0.10110002884169679 0.033645809339839634 3.0072946349187426e-11 10.521824020502434 -0.27790702224025976 NPHPSSAFLNLIGFVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPHPSSAFLNLIGFVSR 17 0 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 133681000.0 21421000.0 30614000.0 81646000.0 False True 29340922.580758616 29261372.25304001 62362896.352152295 1.0 0.9972887584737783 2.1254579224802237 24.806410899290984 -6.90635645886628 0.9201879899068514 0.9609184457599254 2.2604403971051035 0.9894724717148681 0.0545016876169602 0.10687705214012436 0.15220084939928583 0.043832512538003895 0.11815078242783839 1.2406336062160238e-07 6.90635645886628 1.2995219513451781 up NPHPSSAFLNLIGFVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPHPSSAFLNLIGFVSR 17 0 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 185868750.0 67443000.0 49018750.0 69407000.0 False True 56081842.73149189 48754676.264289945 83919682.79829077 1.0 0.8693486855936086 1.4963788404757066 25.741030418265996 -6.852324654665455 1.2237404259477633 0.9301127621591576 1.522603136003378 0.9436296550354875 0.06413040249046696 0.15491908317416125 0.44526124615282275 0.04098000663664517 0.0949865767367814 1.4049968331115992e-07 6.852324654665455 0.5924903738442204 NPHPSSAFLNLIGFVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPHPSSAFLNLIGFVSR 17 0 P53004;C9J1E1 P53004 BLVRA Biliverdin reductase A 0 140931000.0 47765000.0 53646000.0 39520000.0 False True 61832734.088911645 50660552.941375986 32327765.509443324 1.0 0.8193160740479185 0.5228260723997421 25.88186746358806 -6.963722072372379 0.3793473839833014 1.0205160315911843 0.3111523463826875 0.9998843275197791 0.0021156140486426013 0.07839735277534052 0.016405825768427192 0.0038611591167466877 0.02506099364197936 1.0871211063951702e-07 6.963722072372379 -0.7093636852084968 NPIDHVSFYCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPIDHVSFYCK 11 0 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-3;A0A2R8YFV6 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 8977400.0 2175800.0 2126400.0 4675200.0 False True 2852494.8704771707 1809149.4086422808 4191455.1516851024 1.0 0.6342340620369434 1.4693997156895668 21.443792861502004 -6.787656591967024 1.5056120657532948 0.7949496209622908 1.4777265437521625 0.7936669132283442 0.15527198820916682 0.2388613478203802 1.0697062179135892 0.08118462606692634 0.19040839304396984 1.6305848692201563e-07 6.787656591967024 0.6827769227898717 NPIDHVSFYCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPIDHVSFYCK 11 0 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-3;A0A2R8YFV6 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 6655900.0 2175800.0 1988000.0 2492100.0 False True 2980252.0587841165 1900163.586563125 1903517.306410588 1.0 0.6375848582882462 0.6387101724500395 21.507002923024896 -10.162438834432612 5.247235666991745 1.0000145763932253 0.638147515589645 0.9999927454387751 0.0004594075834516526 7.834300309489002e-08 1.250482735738752e-08 0.00044483738238896377 0.0001482731598900187 6.87956796580873e-11 10.162438834432612 -0.36186706080358033 NPIHAIGLLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPIHAIGLLIR 11 0 Q12769;G3V198;E9PR16;Q12769-3 Q12769 NUP160 Nuclear pore complex protein Nup160 0 10328800.0 4257700.0 2969100.0 3102000.0 False True 5581885.931625453 2526121.8534611515 2781034.796485112 1.0 0.45255705408611624 0.49822494234941683 22.412321211900895 -9.981414448136565 7.367987170489518 1.0000000164024776 0.4753909996270684 0.9943486736609132 0.018643837312587758 5.012587160797895e-09 7.301670241218702e-10 0.018051818393247706 0.006017272618421005 1.0437237160787097e-10 9.981414448136565 -0.5246090167754092 NPIHAIGLLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPIHAIGLLIR 11 0 Q12769;G3V198;E9PR16;Q12769-3 Q12769 NUP160 Nuclear pore complex protein Nup160 0 8757900.0 4191700.0 1844500.0 2721700.0 False True 4058636.777920572 2581018.4689404313 2008805.1207501914 1.0 0.635932361077851 0.49494577383182226 21.95256380314145 -13.999999999999998 0.13128876300181508 2.7305408510637696 0.3006976642404848 0.9996398210989356 0.004038335840453738 11.934955780397098 0.11280394479505336 5.323762233045447 0.17283781460265438 1.0000000000000041e-14 13.999999999999998 -2.429843186823285 NPIHAIGLLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPIHAIGLLIR 11 0 Q12769;G3V198;E9PR16;Q12769-3 Q12769 NUP160 Nuclear pore complex protein Nup160 0 14274000.0 4257700.0 3431300.0 6585000.0 False True 5831886.750016153 3279693.820208274 5029758.6223320495 1.0 0.5623726867122703 0.8624582125704204 22.475531273423787 -10.082477643705976 5.497948325426767 1.0000025958228367 0.712415449641227 0.5504727155284102 0.12250940292495639 3.898099149079041e-06 6.507180743324988e-07 0.11862029033997414 0.03953973977345372 8.27032080825359e-11 10.082477643705976 -0.28758714618160963 NPIHAIGLLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPIHAIGLLIR 11 0 Q12769;G3V198;E9PR16;Q12769-3 Q12769 NUP160 Nuclear pore complex protein Nup160 0 7908600.0 4191700.0 1443400.0 2273500.0 False True 3485584.273795565 1435624.1177075314 2748878.338523695 1.0 0.41187474034137583 0.7886420532676872 21.732969078575728 -10.167980376444966 5.427039419797026 1.0000122004557697 0.6002583968044864 0.6001435296577688 0.15381461140510982 2.270668510728065e-05 3.480955548477104e-06 0.1489348986352375 0.04964345236457246 6.792343230623664e-11 10.167980376444966 -0.3997538036512832 NPIIEK(ub)QSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPIIEKQSK 9 1 P86790;P86791 P86790 CCZ1B;CCZ1 Vacuolar fusion protein CCZ1 homolog B;Vacuolar fusion protein CCZ1 homolog 1 2100320.0 443990.0 544530.0 1111800.0 True False 582075.1896052756 463288.24656131596 996761.6011386664 1.0 0.7959250880895421 1.7124275676731786 19.150845999845593 -6.848268980881256 1.2433423171890428 0.8912335969909322 1.7478742490397832 0.9377552430529724 0.09801867584980901 0.15937469389106623 0.474974222442327 0.06171306326058548 0.14266500520740785 1.4181788985887955e-07 6.848268980881256 0.856640652048851 NPIIEK(ub)QSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPIIEKQSK 9 1 P86790;P86791 P86790 CCZ1B;CCZ1 Vacuolar fusion protein CCZ1 homolog B;Vacuolar fusion protein CCZ1 homolog 1 1918800.0 0.0 615900.0 1302900.0 True False 0.0 861832.0818760704 961631.4038378292 0.0 NPIIEK(ub)QSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPIIEKQSK 9 1 P86790;P86791 P86790 CCZ1B;CCZ1 Vacuolar fusion protein CCZ1 homolog B;Vacuolar fusion protein CCZ1 homolog 1 11352330.0 764230.0 1458100.0 9130000.0 True False 1159392.782696849 1197890.6628127033 7325451.49817884 1.0 1.0332052093909925 6.318351819595771 20.14493797919718 -6.908278928499127 0.9073838684094119 0.8273217635565158 6.9767897329348045 0.9902555118383739 0.24671685948342467 0.10556690419907988 0.14502543860786404 0.20028706696343343 0.5465012336457138 1.2351538928986657e-07 6.908278928499127 6.149467969378289 up NPIIEK(ub)QSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPIIEKQSK 9 1 P86790;P86791 P86790 CCZ1B;CCZ1 Vacuolar fusion protein CCZ1 homolog B;Vacuolar fusion protein CCZ1 homolog 1 1968920.0 443990.0 458030.0 1066900.0 True False 608145.1013786008 437792.7200973383 814920.1934952264 1.0 0.719882013527542 1.3400094675561611 19.214056061368485 -6.783880670182953 1.5204870883759145 0.8421882600146297 1.345555707361393 0.7809525351415123 0.11867207955621918 0.24459848401214748 1.1170872261465323 0.06145463938879083 0.1445601308326073 1.6448236044735845e-07 6.783880670182953 0.5033674473467634 NPIIEK(ub)QSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPIIEKQSK 9 1 P86790;P86791 P86790 CCZ1B;CCZ1 Vacuolar fusion protein CCZ1 homolog B;Vacuolar fusion protein CCZ1 homolog 1 2179300.0 0.0 1023300.0 1156000.0 True False 0.0 1017787.2797908538 1397714.255259906 0.0 NPIIEK(ub)QSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPIIEKQSK 9 1 P86790;P86791 P86790 CCZ1B;CCZ1 Vacuolar fusion protein CCZ1 homolog B;Vacuolar fusion protein CCZ1 homolog 1 8451050.0 764230.0 864720.0 6822100.0 True False 989310.8002254567 816597.5718500302 5580547.800657219 1.0 0.8254206581631713 5.640843908087785 19.91606430128963 -6.898488258628903 0.9707891588328839 0.7914033989143578 6.1310443610447845 0.9857986692057445 0.2657479507766332 0.11252614023447136 0.1837681225929679 0.20588231686941022 0.5317133002317166 1.2633152577129758e-07 6.898488258628903 5.339640962130426 up NPK(ub)TDK(ub)LVNER ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPKTDKLVNER 11 2 P05023-4;P05023;P05023-3;Q5TC05 P05023-4 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 2 7919400.0 1177800.0 1762000.0 4979600.0 True False 1140411.3836951253 2465575.7887086114 3675293.375202132 1.0 2.1620055919818424 3.222778576002601 20.121122914903957 -6.97221327123015 0.19831860359236136 0.35474031082401014 5.059278712240444 0.9999948905507542 0.0020518990272831816 0.07559087312065808 0.00639023889907044 0.03492117039341909 0.11309775536546025 1.0660724709607151e-07 6.97221327123015 4.704538401416434 NPK(ub)TDK(ub)LVNER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPKTDKLVNER 11 2 P05023-4;P05023;P05023-3;Q5TC05 P05023-4 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 2 7957800.0 1177800.0 3139800.0 3640200.0 True False 979392.8853869367 3122885.274198499 4401348.989616878 1.0 3.1885929750905992 4.493956465568975 19.901528190338233 -8.511579025018479 0.25746797470392263 4.646765147462772e-17 5.454667099025738 0.9992461262549159 0.03957928573286083 0.17282997625456242 0.07003160589679451 0.6080095107398025 0.4902698320739688 3.079080015492097e-09 8.511579025018479 5.454667099025738 NPK(ub)TDK(ub)LVNER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPKTDKLVNER 11 2 P05023-4;P05023;P05023-3;Q5TC05 P05023-4 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 2 16597400.0 2307200.0 11756000.0 2534200.0 True False 2986715.88171123 11101768.265645474 2073001.6030878345 1.0 3.717048659909609 0.6940739210520802 21.51012857378179 -6.669819777087178 1.937600062672036 2.7345257120611732 0.7061997268149458 0.27837337066483847 1.1541873558011784 0.4615641262428314 3.3404752703602374 0.47953653163232723 1.281694793305047 2.1388494821126421e-07 6.669819777087178 -2.0283259852462274 NPK(ub)VLNPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPKVLNPR 8 1 Q9ULX3 Q9ULX3 NOB1 RNA-binding protein NOB1 1 4601230.0 618860.0 812170.0 3170200.0 True False 938855.8647262888 667231.9179868264 2543608.5804519802 1.0 0.7106862118620829 2.7092641970059335 19.840544163513155 -6.870150313106536 1.1332368581689787 0.8362085677479766 2.826677583964237 0.9648362229031033 0.16537243904785467 0.1367141338428335 0.3280441474409492 0.11323792629949922 0.2681784133453094 1.348496075564853e-07 6.870150313106536 1.9904690162162604 up NPK(ub)VLNPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPKVLNPR 8 1 Q9ULX3 Q9ULX3 NOB1 RNA-binding protein NOB1 1 2978010.0 618860.0 849650.0 1509500.0 True False 801126.4695543566 802366.2305976241 1234786.4887779548 1.0 1.0015475222581987 1.541312808531755 19.611670485605604 -6.907527911227169 0.9124068306869929 0.9819530562311841 1.607501554195049 0.989954616610973 0.0255390887430241 0.10607571629193667 0.1478037587191498 0.02065687209610011 0.056091205880017606 1.237291669149248e-07 6.907527911227169 0.6255484979638649 NPLIINSIIDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPLIINSIIDK 11 0 Q9UNQ2;A0A494C0G7;A0A0C4DGB1;D6RCL3 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 0 3097520.0 543820.0 760000.0 1793700.0 False True 712953.2863603722 646610.9624567975 1608105.1303853453 1.0 0.9069471658623632 2.255554692222158 19.443448026920784 -6.890359276589515 1.020215332103239 0.9281609580725192 2.3723844761993433 0.9811286444332502 0.08448186670073599 0.11885369310452279 0.22012947678061992 0.06306331925089079 0.15742856472943606 1.2871842687281082e-07 6.890359276589515 1.4442235181268241 up NPLIINSIIDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPLIINSIIDK 11 0 Q9UNQ2;A0A494C0G7;A0A0C4DGB1;D6RCL3 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 0 3164720.0 543820.0 1037400.0 1583500.0 False True 744884.9501829126 991564.2377769557 1209509.9132061966 1.0 1.3311642791728695 1.623753994370797 19.506658088443675 -6.972584236793669 0.1863942677657047 0.7921083679128097 2.170773329329614 0.9999961517225802 0.0004998256971242316 0.07547273087990876 0.005921338983401812 0.010654499086757552 0.03222114705013304 1.0651622422204959e-07 6.972584236793669 1.378664961416804 NPLK(ub)NLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPLKNLR 7 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 9397700.0 2090800.0 3162700.0 4144200.0 True False 2741059.047336001 2690837.4881080426 3715397.9379734322 1.0 0.9816780454705024 1.355460744847645 21.38630197606549 -6.895373734511514 0.9900269956265679 0.9824261408133019 1.3912121916452078 0.984121516117061 0.02167961738040522 0.11489214146663423 0.1972341101444621 0.016555597669493154 0.04215829160471999 1.2724076323317944e-07 6.895373734511514 0.4087860508319059 NPLK(ub)NLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPLKNLR 7 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 15338000.0 3061000.0 4886700.0 7390300.0 True False 2963830.230506689 6837984.793803843 5454558.725752334 1.0 2.3071445602452196 1.8403748870662666 21.499031381130983 -10.269598246093624 5.1687700976357585 0.9998198524493175 2.073759723655977 0.8758661939728651 0.19055792111649802 0.0003956536663165274 5.5909887453788614e-05 0.18453700361660755 0.061502304580891516 5.3752881960253795e-11 10.269598246093624 1.0739398712066595 NPLK(ub)NLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPLKNLR 7 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 9229300.0 2090800.0 2807300.0 4331200.0 True False 2863825.2617454883 2683264.203500332 3308259.763864019 1.0 0.9369510910260267 1.155189112986471 21.44951203758838 -6.829455427479319 1.3305753873538342 0.966299172566793 1.1609869418197374 0.904734764186385 0.028304509330288698 0.1814873177678941 0.6286295179587044 0.01670417440398326 0.038437226456061284 1.480964241822203e-07 6.829455427479319 0.1946877692529444 NPLK(ub)NLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPLKNLR 7 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 12487100.0 3061000.0 6076800.0 3349300.0 True False 2545357.125292421 6044063.072249636 4049623.144586507 1.0 2.3745442288595435 1.5909842687089617 21.27943665656526 -10.224672056878195 5.1355312352020706 0.999897498910923 1.9827642487846857 0.6771544659842794 0.31988701420891613 0.00037545455788797453 5.668315197202194e-05 0.30976110582683714 0.10324308989137897 5.961121079727686e-11 10.224672056878195 0.9828667498737627 NPLPSK(ub)ETIEQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPLPSKETIEQEK 13 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 17035800.0 7426100.0 5776400.0 3833300.0 True False 9735689.014454702 4914583.6362308515 3436666.8876100522 1.0 0.5048008034083779 0.35299678148178204 23.21485165433662 -13.999999999999998 0.16561049083589996 3.4699169208976945 0.21263323667787284 0.9995227470159811 0.0060352222442301125 12.051843224892325 0.128770726250771 9.560283259802553 0.12889106712998513 1.0000000000000041e-14 13.999999999999998 -3.257283684219822 NPLPSK(ub)ETIEQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPLPSKETIEQEK 13 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 26939500.0 11574000.0 7732300.0 7633200.0 True False 11206589.70528729 10819847.713411823 5633835.928908526 1.0 0.9654897696760503 0.5027252783467634 23.41784398037425 -6.921856555549133 0.8108588069969893 1.0095440759825116 0.42482317112519974 0.9946807254898724 0.016535564950205615 0.09709216857417895 0.10005088895394915 0.014388837878882553 0.04389561648299888 1.197135871677956e-07 6.921856555549133 -0.5847209048573119 NPLPSK(ub)ETIEQEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPLPSKETIEQEK 13 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 34131600.0 15198000.0 11489000.0 7444600.0 True False 23056477.122628953 9438698.186033286 5973171.54691591 1.0 0.4093729556268423 0.25906696479027563 24.45866875976954 -13.99999999999983 0.19216044993039294 4.1901062023837525 0.15354893885035512 0.9994883648087334 0.007233532041492716 12.386709153393983 0.139014472060674 14.806670231208342 0.10161907841850762 1.0000000000003927e-14 13.99999999999983 -4.036557263533397 NPLPSK(ub)ETIEQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPLPSKETIEQEK 13 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 19240400.0 7426100.0 6724100.0 5090200.0 True False 10171729.85280667 6427007.028374805 3887999.5959597 1.0 0.6318499528967937 0.3822358293252244 23.27806171585951 -8.19422800305777 0.17529569456441427 1.3218183652539564 2.331206545574797e-14 0.9998751073155181 0.0028357204309803754 0.085971833180594 0.035461852691060294 0.1105783625084491 0.11986102231363992 6.393990651170461e-09 8.19422800305777 -1.321818365253933 down NPLPSK(ub)ETIEQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPLPSKETIEQEK 13 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 32005400.0 11574000.0 15976000.0 4455400.0 True False 9624293.815137034 15889934.117012277 5387003.540557938 1.0 1.6510233812709125 0.5597297468293507 23.198249255808527 -6.745116971816525 1.6678443375358627 1.3850477938725387 0.5583374627969993 0.6276977594200666 0.2735248377508397 0.308654957022604 1.687641697519026 0.1296378673833395 0.31636504782291447 1.798386476865535e-07 6.745116971816525 -0.8267103310755395 NPLPSK(ub)ETIEQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPLPSKETIEQEK 13 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 31966700.0 15198000.0 10939000.0 5829700.0 True False 19674110.597367942 10330235.03384619 4768754.417773327 1.0 0.5250674475332164 0.24238729340127346 24.22979508186199 -8.643533484692616 0.23144130504470678 1.2840856389155784 2.2385242907393827e-22 0.9994528254301576 0.007312167892191734 0.23139848070157798 0.06508691189675593 0.1663031215410811 0.11838695427544636 2.2723044307682256e-09 8.643533484692616 -1.2840856389155784 down NPLVAVYYTNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPLVAVYYTNR 11 0 Q9UNE7 Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP 0 37495000.0 13028000.0 11301000.0 13166000.0 False True 17079834.163331456 9614934.850952987 11803708.617189877 1.0 0.5629407615441141 0.6910903527700025 24.025790631388862 -10.560523298532475 9.493227470756715 1.000025097959992 0.6270155571570611 0.9186660351907409 0.05231685154161181 2.779238544025799e-05 1.2865202141781295e-06 0.05065896736134841 0.016885191228889034 2.750912023257269e-11 10.560523298532475 -0.3730095408029309 NPLVAVYYTNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPLVAVYYTNR 11 0 Q9UNE7 Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP 0 33520100.0 11783000.0 6131100.0 15606000.0 False True 11408955.11468812 8579280.203264125 11518320.430035427 1.0 0.7519777330194757 1.0095859186268958 23.443663333148795 -11.064918285167021 10.83630552173324 1.6023055129942252 0.8807818258231858 0.22213165359445175 0.1051681013837268 0.04237642243139204 0.0002538695866809097 0.002819753312078198 0.03394285876761891 8.611557680124045e-12 11.064918285167021 -0.7215236871710394 NPLVAVYYTNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPLVAVYYTNR 11 0 Q9UNE7 Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP 0 60226000.0 15918000.0 22614000.0 21694000.0 False True 24148769.761679642 18578355.016011547 17406171.391182 1.0 0.7693292535958713 0.720789156671778 24.525446358285734 -13.999999999999998 0.2190656588985579 2.3862920089067545 0.6945913538876108 0.9994969717575956 0.002731827986223211 12.974308422722913 0.1482802040900807 7.776943674252005 0.02702964110802283 1.0000000000000041e-14 13.999999999999998 -1.6917006550191438 NPLVAVYYTNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPLVAVYYTNR 11 0 Q9UNE7 Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP 0 37509000.0 13028000.0 10630000.0 13851000.0 False True 17844803.668461934 10160331.451290762 10579679.07029936 1.0 0.5693719942264007 0.5928716990592274 24.089000692911753 -10.412146566843557 5.927290759689144 1.0001373123145971 0.5811218466428153 0.9976450219978119 0.009593714324407745 1.7413856335279038e-05 1.7270621219796384e-06 0.009292086065937335 0.003096357983891771 3.871269742442516e-11 10.412146566843557 -0.41901546567178183 NPLVAVYYTNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPLVAVYYTNR 11 0 Q9UNE7 Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP 0 22971700.0 11783000.0 6017900.0 5170800.0 False True 9798086.57540693 5985480.378240381 6251990.37292207 1.0 0.6108825771415267 0.6380827853281563 23.22406860858307 -10.743250776409079 6.880384893367478 1.0064283050401246 0.6244826812349342 0.9960804131273489 0.011104438492452707 0.0011022971999298974 4.1133394239199446e-05 0.01082363791658283 0.0035839421125211652 1.8061309034133966e-11 10.743250776409079 -0.38194562380519037 NPLVAVYYTNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPLVAVYYTNR 11 0 Q9UNE7 Q9UNE7 STUB1 E3 ubiquitin-protein ligase CHIP 0 58570000.0 15918000.0 24026000.0 18626000.0 False True 20606164.790689733 22688931.97944862 15236259.118899085 1.0 1.1010749554764272 0.7394029540995967 24.296572680378183 -6.832117673681319 1.3184519675809057 1.0539327726692373 0.7292448532673558 0.9100404259684829 0.0456989881993529 0.1782109033679648 0.6051149823723654 0.0272086325110286 0.06261275980353799 1.471913628005664e-07 6.832117673681319 -0.3246879194018816 NPNAGDK(ub)FK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPNAGDKFK 9 1 O60884 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 2913960.0 561630.0 852230.0 1500100.0 True False 543801.363070719 1192529.8833207374 1107178.807964638 1.0 2.1929512581336694 2.035998589103673 19.05272024200563 -10.157685293816547 5.0361642672529054 0.9999361684962214 2.114474923620454 0.9853429859143246 0.06407565882142456 4.592554752574869e-05 7.681028116461313e-06 0.06204450793249487 0.020680329958500807 6.955281409807734e-11 10.157685293816547 1.1145387551242325 NPNAGDK(ub)FK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPNAGDKFK 9 1 O60884 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 2877970.0 560280.0 785690.0 1532000.0 True False 767430.6569976858 750975.6178706144 1170173.1525304045 1.0 0.9785582723637257 1.5247933371704399 19.54967687270447 -6.897764042987134 0.9753043910291136 0.9758744815697964 1.5795940015801582 0.9854199818928213 0.03050034094885215 0.11307053423601322 0.18685302584865632 0.02354984917280278 0.06061281607264227 1.2654236794684713e-07 6.897764042987134 0.6037195200103618 NPNAGDK(ub)FK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPNAGDKFK 9 1 O60884 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 2131350.0 561630.0 654920.0 914800.0 True False 467020.22942763194 651391.8159685588 1106080.4504427009 1.0 1.3947828700415996 2.3683780289309624 18.833125517439907 -6.955753124659389 0.4916465264640667 0.9790081149687448 2.8255530683875434 0.9995788304702912 0.011801526429403793 0.0812545545643508 0.027013578291558798 0.014067711184132328 0.08029958106527155 1.1072530247339712e-07 6.955753124659389 1.8465449534187985 up NPNEGEK(ub)FK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPNEGEKFK 9 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 3749220.0 688320.0 1139800.0 1921100.0 True False 902394.1857003609 969746.282905603 1722323.0004924394 1.0 1.0746371134394768 1.9086149132883874 19.783398246641294 -6.924448289464344 0.7910268487221509 0.9843781358889232 2.05790093496247 0.9953302194021056 0.02814489702256618 0.09562448232279386 0.09256298119822176 0.024839788533108885 0.07789046033412521 1.1900130130854869e-07 6.924448289464344 1.073522799073547 NPNEGEK(ub)FK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPNEGEKFK 9 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 4934750.0 815750.0 1149000.0 2970000.0 True False 789854.4627689737 1607801.6919558437 2192067.901909855 1.0 2.0355670161303037 2.775280770365183 19.591227323695854 -7.830207919215802 0.15859996232324483 3.7232614628226208e-09 4.188804478354268 0.9999533326052047 0.004973921411912724 0.12882341391549096 0.023107288948968883 0.22854329152329605 0.31826900495390703 1.4784004320134584e-08 7.830207919215802 4.188804474631007 NPNEGEK(ub)FK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPNEGEKFK 9 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 3734420.0 688320.0 962600.0 2083500.0 True False 942810.5051485809 920069.1491074773 1591420.2110294362 1.0 0.975879186838802 1.6879534141154258 19.846608308164186 -6.899061268356629 0.9672058019687362 0.9696261870204812 1.7612827912904607 0.9860924551603609 0.038933089674552876 0.11209962725467146 0.18135370379530716 0.03024314556646902 0.0783214769585087 1.2616495340643302e-07 6.899061268356629 0.7916566042699795 NPNEGEK(ub)FK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPNEGEKFK 9 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 3409650.0 815750.0 1180700.0 1413200.0 True False 678332.2688524304 1174339.3347493985 1708693.5861014668 1.0 1.7312154952263863 2.5189625564948455 19.37163259913013 -6.970175757367301 0.25395707578867094 0.7618661218944126 3.5115008783964936 0.9999837200743379 0.0025026304909330863 0.07624575288134837 0.008826046777534503 0.017108998944276393 0.07501963831693488 1.0710857530802948e-07 6.970175757367301 2.749634756502081 NPNGPYPYTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPNGPYPYTLK 11 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 17105360.0 733460.0 8373000.0 7998900.0 False True 961573.1628367435 7123781.037698378 7171250.558866785 1.0 7.408464912521542 7.457831432931042 19.875037105944898 -10.19766480865136 1.0084993805409883 2.767342649802003e-15 7.444453642866508 0.9999901658230597 0.00951033503371039 1.581192272369363 0.5983378081589074 4.775864537070429 0.006476939002030493 6.343591249273688e-11 10.19766480865136 7.444453642866505 NPNGPYPYTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPNGPYPYTLK 11 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 20133500.0 6081100.0 2159400.0 11893000.0 False True 5888058.809125851 3021659.6811222364 8777866.517647786 1.0 0.5131843582198928 1.4907912441436637 22.489360650231756 -6.771307516690441 1.5694366021494053 0.7212427386847804 1.4965654067020502 0.7355439544584992 0.20524215850942568 0.2643190657541958 1.2850526614334825 0.10306817537753692 0.24505312057447348 1.6931384927212292e-07 6.771307516690441 0.7753226680172698 NPNGPYPYTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPNGPYPYTLK 11 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 25217460.0 733460.0 10471000.0 14013000.0 False True 1004639.983011214 10008356.597033445 10703418.006794075 1.0 9.962132471609713 10.653983703408509 19.93824716746779 -9.626158614323792 0.7085270761744921 1.0152167027778614e-16 10.537881900953394 0.999398682691554 0.10782080572315751 0.9338716354918691 0.3456074953041152 2.6576613621172833 0.10642884213449612 2.36505576702255e-10 9.626158614323792 10.537881900953394 NPNLLFTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPNLLFTLK 9 0 Q96S59;Q96S59-2;Q96S59-3 Q96S59 RANBP9 Ran-binding protein 9 0 6242000.0 1890400.0 1972700.0 2378900.0 False True 2478332.70665964 1678380.8495243746 2132754.248020127 1.0 0.6772217648640642 0.86056010247902 21.240938446079443 -10.165618833887853 5.20859129361639 1.0000104199621072 0.768890934704123 0.6793518991305749 0.0748475629082877 9.056974177918695e-06 1.4510294248462771e-06 0.07247410681886575 0.02415694705392954 6.829378234542636e-11 10.165618833887853 -0.2311194852579842 NPNLLFTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPNLLFTLK 9 0 Q96S59;Q96S59-2;Q96S59-3 Q96S59 RANBP9 Ran-binding protein 9 0 4593800.0 1842800.0 1022600.0 1728400.0 False True 1784301.3226977207 1430929.5127885528 1275680.1891114472 1.0 0.8019550815694638 0.7149466140521159 20.76692783932084 -13.999999999999547 0.11170075806924326 1.9529001729644955 0.559170959420437 0.9997344321480679 0.001943795017912054 12.002923561234416 0.10169249044886239 2.571543615377897 0.13830874099045914 1.000000000001043e-14 13.999999999999547 -1.3937292135440584 NPNLLFTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPNLLFTLK 9 0 Q96S59;Q96S59-2;Q96S59-3 Q96S59 RANBP9 Ran-binding protein 9 0 6026100.0 1890400.0 1748200.0 2387500.0 False True 2589331.9661391196 1670958.7434756833 1823621.6721059661 1.0 0.6453242632952942 0.7042826860184781 21.304148507602335 -10.570814410663274 6.379577153175636 1.0005944609297506 0.6748034746568937 0.9759406107472229 0.024069675285185586 0.00020386713656576108 1.3715134205863318e-05 0.023346181296203722 0.007768454294011995 2.6864922331996783e-11 10.570814410663274 -0.32579098627285685 NPPGFAFVEFEDPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPPGFAFVEFEDPR 14 0 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629;P84103;P84103-2;A0A087X2D0 A0A0B4J1Z1;P84103 SRSF7;SRSF3 Serine/arginine-rich splicing factor 7;Serine/arginine-rich splicing factor 3 0 86687000.0 18106000.0 31425000.0 37156000.0 False True 23737141.33875344 26736512.493690602 33311453.545519244 1.0 1.1263577240465923 1.4033473142418673 24.500642866051884 -6.958212205660848 0.45993802199665534 0.9919212496303282 1.5489486005298978 0.9996980348202954 0.0029271740995759133 0.08034606152869708 0.023538604828990634 0.003761435334561183 0.022882278798836236 1.1010012051265119e-07 6.958212205660848 0.5570273508995696 NPPGFAFVEFEDPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPPGFAFVEFEDPR 14 0 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629;P84103;P84103-2;A0A087X2D0 A0A0B4J1Z1;P84103 SRSF7;SRSF3 Serine/arginine-rich splicing factor 7;Serine/arginine-rich splicing factor 3 0 74872000.0 28063000.0 13896000.0 32913000.0 False True 27172155.425909564 19444745.266682696 24292097.931164704 1.0 0.715612911890732 0.894007028533385 24.695625675812366 -10.43075462283236 5.660727050109361 1.0001169808912056 0.804809970212058 0.614824734156084 0.07282909314817548 0.00010758530245055102 1.08187681441815e-05 0.07055856354252091 0.023505488740189144 3.708902162375104e-11 10.43075462283236 -0.19530701067914757 NPPGFAFVEFEDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPPGFAFVEFEDPR 14 0 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629;P84103;P84103-2;A0A087X2D0 A0A0B4J1Z1;P84103 SRSF7;SRSF3 Serine/arginine-rich splicing factor 7;Serine/arginine-rich splicing factor 3 0 82411000.0 18106000.0 31566000.0 32739000.0 False True 24800277.49625209 30171309.745197017 25006722.480870016 1.0 1.216571457708754 1.0083243013973986 24.563852927574775 -10.849593626241402 2.929093769062981 0.9592257664602619 1.1124478796010044 0.2799338888838516 0.08501654584074275 64073497.19333497 22154228.57494281 17831219.24482684 0.031112869106989773 1.4138598889218618e-11 10.849593626241402 0.15322211314074252 NPPGFAFVEFEDPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPPGFAFVEFEDPR 14 0 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629;P84103;P84103-2;A0A087X2D0 A0A0B4J1Z1;P84103 SRSF7;SRSF3 Serine/arginine-rich splicing factor 7;Serine/arginine-rich splicing factor 3 0 22275200.0 5553200.0 16722000.0 0.0 False True 7188726.869937077 15791406.000180606 0.0 1.0 2.1966902187116797 0.0 22.777304860007856 -6.762376467414689 1.6272197769902874 1.695986881734275 5.920125412722095e-11 0.6857795821597514 0.5033730139080967 0.28223111654145316 1.477331458341582 0.24500542500888775 0.5819080495660758 1.728317520645737e-07 6.762376467414689 -1.6959868816750736 NPPINTK(ub)SQAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPPINTKSQAVK 12 1 O15511;B1ALC0;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 22242200.0 18988900.0 1952700.0 1300600.0 True False 24894631.78876919 1661364.7715649856 1166026.3882361494 1.0 0.06673586440890776 0.04683846694861273 24.569331341176245 NPPINTK(ub)SQAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPPINTKSQAVK 12 1 O15511;B1ALC0;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 105542500.0 33823500.0 33939100.0 37779900.0 True False 32749791.506547812 47491159.62006839 27884210.817294333 1.0 1.450120975902191 0.8514317048925126 24.964982386329503 -6.7055773248471455 1.8113386065341173 1.2779749978666457 0.8530366111898703 0.44389402405344913 0.18981602442049222 0.3840429910382924 2.4534173249005558 0.08348918052920383 0.21321777168584355 1.9698024584949802e-07 6.7055773248471455 -0.4249383866767754 NPPINTK(ub)SQAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPPINTKSQAVK 12 1 O15511;B1ALC0;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 139967900.0 34740700.0 4942000.0 100285200.0 True False 52704181.78537412 4060061.487977761 80463786.26343542 1.0 0.0770349021736348 1.5267059185380398 25.65141410048903 -6.734712165107916 1.7062614887823724 0.4475023280798086 1.5265820506056038 0.5809202084862061 0.38786817043923405 0.3274520802637886 1.8697104699993718 0.17999922381459002 0.4442566765469513 1.8419924038693438e-07 6.734712165107916 1.0790797225257953 NPPINTK(ub)SQAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPPINTKSQAVK 12 1 O15511;B1ALC0;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 21742300.0 18988900.0 1418900.0 1334500.0 True False 26009609.48572744 1356208.3063251604 1019318.584890223 1.0 0.05214258626487139 0.03919007647729451 24.632541402699136 NPPINTK(ub)SQAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPPINTKSQAVK 12 1 O15511;B1ALC0;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 99937700.0 33823500.0 45704400.0 20409800.0 True False 28125738.885112077 45458181.32558692 24677394.815747067 1.0 1.61624843035322 0.8773954318693353 24.74538766176378 -6.6854025945578455 1.8829466126627474 1.3880120638078914 0.8800971649138841 0.3488611310958667 0.26087989493659486 0.4266552321573068 2.9291671272357247 0.11099312522965617 0.2906991728630559 2.06346641857548e-07 6.6854025945578455 -0.5079148988940073 NPPINTK(ub)SQAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPPINTKSQAVK 12 1 O15511;B1ALC0;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 1 172362100.0 34740700.0 46164300.0 91457100.0 True False 44972520.991576575 43595216.123318866 74812846.22909184 1.0 0.9693745238672371 1.6635235156842643 25.42254042258148 -6.896579696027387 0.9826423769716962 0.9683682699636028 1.7315285170448387 0.9847858331894294 0.03950154443393612 0.11396782727707978 0.19196217291556392 0.030332985982292098 0.07765002230781247 1.2688792749965422e-07 6.896579696027387 0.7631602470812359 NPPINTK(ub)SQAVK(ub)DR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPPINTKSQAVKDR 14 2 O15511;B1ALC0;O15511-2 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 2 6620850.0 543750.0 1763400.0 4313700.0 True False 824908.5034497622 1448707.4924929147 3461095.3042381275 1.0 1.7562038534388105 4.195732362757625 19.653874582959336 -6.949807171462889 0.5609558917859738 0.9682524504046398 5.100464339476318 0.9991860691613823 0.03890418896495274 0.0835632516439456 0.03628342299046027 0.041655087100447456 0.20283333901150738 1.1225167457263771e-07 6.949807171462889 4.132211889071678 NPPLAEALLSGDLEK(ub)FSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPPLAEALLSGDLEKFSR 18 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2;H0YII4;H0YI90 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 108655020.0 43865400.0 39822900.0 24966720.0 True False 57507964.19313783 33881478.54844837 22383403.312089186 1.0 0.5891615017818922 0.38922266900138497 25.777258430812864 -12.367717806283183 0.11179508770352203 2.4213527169886944 8.38308115969067e-15 0.9997900275161241 0.003684266393176995 6.538157008491616 0.08448987040560901 2.4432508447453305 0.30261632557400936 4.2882707101967755e-13 12.367717806283183 -2.421352716988686 NPPLAEALLSGDLEK(ub)FSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPPLAEALLSGDLEKFSR 18 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2;H0YII4;H0YI90 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 463060900.0 172157900.0 162185300.0 128717700.0 True False 166692841.69896987 226946736.07516637 95002672.92177193 1.0 1.3614665978579263 0.5699265304585603 27.312616911010895 -6.782527470420063 1.5257907777918756 1.2040029101748255 0.5631277114336992 0.7762819051707515 0.1530350583917094 0.24668124646327988 1.1344214122828056 0.0789805966356788 0.18598943068471624 1.649956633345977e-07 6.782527470420063 -0.6408751987411263 NPPLAEALLSGDLEK(ub)FSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPPLAEALLSGDLEKFSR 18 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2;H0YII4;H0YI90 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 331325000.0 113134000.0 147707000.0 70484000.0 True False 171632549.20328352 121347531.80994165 56552806.50576532 1.0 0.7070193408723207 0.3294993098237068 27.354747937351032 -7.045825685103174 0.32153212487864363 1.053473620212355 8.718751992619657e-11 0.9999507002336633 0.0019270444051807795 0.07285415675908398 0.012603221538074572 0.005991297073390897 0.03177436533368729 8.998586897315403e-08 7.045825685103174 -1.0534736201251673 down NPPLAEALLSGDLEK(ub)FSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPPLAEALLSGDLEKFSR 18 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2;H0YII4;H0YI90 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 149712500.0 43865400.0 44940500.0 60906600.0 True False 60083623.797862306 42954880.1116399 46521715.49080171 1.0 0.7149182655186017 0.7742827837301133 25.840468492335756 -10.770732496168215 7.001532504810995 1.0063386403976533 0.7446005246244277 0.9610574375134221 0.024235463074060458 0.0024321314505652597 7.964086872840226e-05 0.02380025417285774 0.00782196207278842 1.6953817498612637e-11 10.770732496168215 -0.2617381157732256 NPPLAEALLSGDLEK(ub)FSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPPLAEALLSGDLEKFSR 18 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2;H0YII4;H0YI90 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 360986700.0 172157900.0 141425000.0 47403800.0 True False 143156921.73811808 140663115.45433533 57315715.40959291 1.0 0.9825799112365328 0.40036985088602656 27.09302218644517 -6.913289461414119 0.8730325913047654 1.0162057761534227 0.31958411901111466 0.9921048202973278 0.024759678120816832 0.1022830269469367 0.1272650520566154 0.020606679234365845 0.05826783981149812 1.2209855903616685e-07 6.913289461414119 -0.6966216571423081 down NPPLAEALLSGDLEK(ub)FSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPPLAEALLSGDLEKFSR 18 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2;H0YII4;H0YI90 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 338949000.0 113134000.0 179494000.0 46321000.0 True False 146454193.20454168 169505001.11209294 37891053.293596245 1.0 1.1573926113222166 0.25872289802366144 27.12587425944348 -6.861703017497957 1.1771932928194846 1.0858022490465966 0.2137871541991835 0.9556719114453718 0.08249964229977048 0.14505225275561598 0.3810103689012175 0.05462402530206381 0.1277551669428295 1.3749819040145794e-07 6.861703017497957 -0.8720150948474131 down NPQLYTK(ub)ECLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPQLYTKECLER 12 1 Q9BTT4 Q9BTT4 MED10 Mediator of RNA polymerase II transcription subunit 10 1 4420500.0 1089500.0 1192000.0 2139000.0 True False 1428345.050733007 1014158.2463796072 1917676.798736832 1.0 0.7100232859414153 1.3425865113984234 20.445913108108865 -6.782092667468763 1.5279985519894097 0.8362521879486763 1.347904434193022 0.7746251475392831 0.12273859399699447 0.24734166806686644 1.1408135246225652 0.06326188213170615 0.148994900816052 1.6516093489259713e-07 6.782092667468763 0.5116522462443457 NPQLYTK(ub)ECLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPQLYTKECLER 12 1 Q9BTT4 Q9BTT4 MED10 Mediator of RNA polymerase II transcription subunit 10 1 5045570.0 1103000.0 894170.0 3048400.0 True False 1067985.868751676 1251216.7440349506 2249932.589960272 1.0 1.1715667600522144 2.10670632991626 20.026461127195375 -6.937900900504683 0.6788174743675627 0.9890246815534921 2.3440326424923823 0.9978757478331323 0.0224151187068362 0.08873753877904163 0.0590706905787568 0.021486818150569718 0.08125806934502301 1.1537164886080541e-07 6.937900900504683 1.3550079609388903 up NPQLYTK(ub)ECLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPQLYTKECLER 12 1 Q9BTT4 Q9BTT4 MED10 Mediator of RNA polymerase II transcription subunit 10 1 28376400.0 2757400.0 13160000.0 12459000.0 True False 4183177.3929422954 10811495.180450702 9996473.189026318 1.0 2.584517500666231 2.389684263902364 21.996167747916132 -9.89186659306291 5.941234241655619 0.9999996121758898 2.4871008822852803 0.9872898358294018 0.07954033583788311 4.086057685584205e-07 7.629811566278608e-08 0.07701461851851346 0.025671533003811156 1.282724550528462e-10 9.89186659306291 1.4871012701093904 NPQLYTK(ub)ECLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPQLYTKECLER 12 1 Q9BTT4 Q9BTT4 MED10 Mediator of RNA polymerase II transcription subunit 10 1 5637900.0 1089500.0 1231200.0 3317200.0 True False 1492317.5926304322 1176801.5129660584 2533745.679878495 1.0 0.7885731018501031 1.697859552410952 20.509123169631756 -6.845494623405055 1.256793607406973 0.8874754457740411 1.731137153031411 0.9334587940724992 0.1002202957176385 0.1624913371520425 0.49619931823125957 0.06246704255782701 0.1441832617665906 1.4272674997233217e-07 6.845494623405055 0.8436617072573699 NPQLYTK(ub)ECLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPQLYTKECLER 12 1 Q9BTT4 Q9BTT4 MED10 Mediator of RNA polymerase II transcription subunit 10 1 6245000.0 1103000.0 1133600.0 4008400.0 True False 917193.371185084 1127493.0717980172 4846537.907252419 1.0 1.2292861104536876 5.28409609087157 19.80686640262965 -6.918540449058985 0.8354742320597138 0.9057405881173827 5.91652491512753 0.9937659197263915 0.15536420752092509 0.09903828066275688 0.11011837825550701 0.1328377506148672 0.3925295075783796 1.2063117302262807e-07 6.918540449058985 5.010784327010147 up NPQLYTK(ub)ECLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPQLYTKECLER 12 1 Q9BTT4 Q9BTT4 MED10 Mediator of RNA polymerase II transcription subunit 10 1 25988000.0 2757400.0 9269600.0 13961000.0 True False 3569508.6564799524 8753738.611366726 11420241.251956932 1.0 2.452365144282678 3.199387465057706 21.76729407000858 -9.061921752463661 0.22913847443890542 3.551576788343275e-22 3.8042660252991753 0.9993330912596341 0.023581908746825996 0.5189923427767605 0.0789189377390193 0.7501734168447138 0.34892183211824046 8.671180917482407e-10 9.061921752463661 3.8042660252991753 NPQNSSQSADGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPQNSSQSADGLR 13 0 P0DN76;Q01081 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 0 8048000.0 2668200.0 950200.0 4429600.0 False True 2583499.4514988405 1329619.8152275388 3269354.8748484575 1.0 0.5146584468814762 1.2654753508663266 21.300895146789294 -6.732209620398352 1.715296772436705 0.7086391771690741 1.2652003053224425 0.5693992618190399 0.20399322680768994 0.3321246322688009 1.9154149412155408 0.09420817003089926 0.2331776640205554 1.852637197395291e-07 6.732209620398352 0.5565611281533684 NPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQK 41 0 P11940;E7EQV3;E7ERJ7;H0YAS6;H0YB75;H0YAS7 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 0 18925600.0 2590400.0 11870000.0 4465200.0 False True 3396039.485469283 10099042.26889761 4003183.9372228645 1.0 2.9737705677771498 1.1787801509232696 21.695421802408163 -6.623538301156201 2.1040303512492837 2.3064068761722782 1.1857986772525575 0.09473375906612769 0.8480305968526042 0.5759760292298972 4.850160444576271 0.3306408156414119 0.9398506143204282 2.3793684512226499e-07 6.623538301156201 -1.1206081989197207 NPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPQQHLNAQPQVTMQQPAVHVQGQEPLTASMLASAPPQEQK 41 0 P11940;E7EQV3;E7ERJ7;H0YAS6;H0YB75;H0YAS7 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 0 24236700.0 2590400.0 12128000.0 9518300.0 False True 3548140.882927833 11592144.858067194 7270273.575541871 1.0 3.267103883570051 2.04903745804553 21.758631863931054 -10.218865907984357 5.855710707375671 0.9999557912994643 2.6580706708078097 0.711865586026251 0.49727353589188267 0.0002870101300445227 3.8285904679824486e-05 0.4814956924505463 0.16049434358490142 6.041351323048449e-11 10.218865907984357 1.6581148795083454 NPQQQESLK(ub)HATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPQQQESLKHATR 13 1 O95816;O95816-2 O95816 BAG2 BAG family molecular chaperone regulator 2 1 23357500.0 1357200.0 8532300.0 13468000.0 True False 1779302.3431434978 7259314.098644912 12074460.554178433 1.0 4.079865418386324 6.786064549797903 20.762880246816575 -7.536567087811248 0.2636526440500531 4.231743927478275e-19 9.399854580587169 0.9997906960788747 0.03419778641889497 0.13597514041690195 0.02981164528792129 0.24795676564554192 0.6073011814774407 2.9069188773198595e-08 7.536567087811248 9.399854580587169 NPQQQESLK(ub)HATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPQQQESLKHATR 13 1 O95816;O95816-2 O95816 BAG2 BAG family molecular chaperone regulator 2 1 53122700.0 13140800.0 12853600.0 27128300.0 True False 12723652.496910267 17986109.510638483 20022584.398444843 1.0 1.413596411486884 1.5736506795754603 23.601009539454477 -11.78160785829356 0.16306222783403346 4.8058190844962885e-20 1.7467995158339542 0.9995408958172336 0.005178757605000691 4.83978745351245 0.10553424124079606 1.8102109037163217 0.13644115308870178 1.6534540936579056e-12 11.78160785829356 1.7467995158339542 NPQQQESLK(ub)HATR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPQQQESLKHATR 13 1 O95816;O95816-2 O95816 BAG2 BAG family molecular chaperone regulator 2 1 24918900.0 1540800.0 19492900.0 3885200.0 True False 2337506.247568544 16014239.696277171 3117288.5170563487 1.0 6.850993323733385 1.333595801208629 21.156538790291982 -6.6323356901922415 2.0717303076761566 4.848126800632917 1.3558898415136877 0.12600962152314743 2.508281582251949 0.5529833402669952 4.525949386851178 0.9891352415915354 2.7786960951535264 2.331655100556014e-07 6.6323356901922415 -3.4922369591192295 NPQQQESLK(ub)HATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPQQQESLKHATR 13 1 O95816;O95816-2 O95816 BAG2 BAG family molecular chaperone regulator 2 1 9737900.0 1357200.0 5618100.0 2762600.0 True False 1858993.5169509193 5369873.7654277105 2110130.777532958 1.0 2.8885919808022034 1.135093134156782 20.826090308339467 -6.628601900600541 2.085359018702588 2.2455040340793535 1.1420991234405269 0.1124873015971547 0.8103940362079197 0.5627038147695956 4.661321929363398 0.31802948157385186 0.8979018537507092 2.3517876174206926e-07 6.628601900600541 -1.1034049106388266 NPQQQESLK(ub)HATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPQQQESLKHATR 13 1 O95816;O95816-2 O95816 BAG2 BAG family molecular chaperone regulator 2 1 42303900.0 13140800.0 12008600.0 17154500.0 True False 10927157.43614592 11943907.288279533 20741426.636553645 1.0 1.0930479731874558 1.8981539121915756 23.381414814888753 -6.928666137951701 0.7576553283240355 0.9871324704825925 2.057963604440603 0.9962697330961844 0.02462918763297855 0.09333587422201156 0.08111480770995952 0.022263066364936513 0.07338944905272135 1.1785116011923124e-07 6.928666137951701 1.0708311339580106 NPQQQESLK(ub)HATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPQQQESLKHATR 13 1 O95816;O95816-2 O95816 BAG2 BAG family molecular chaperone regulator 2 1 26532300.0 1540800.0 13623300.0 11368200.0 True False 1994595.973708683 12865151.379156843 9299304.24758233 1.0 6.450003684323008 4.662249583453998 20.92766511238443 -9.528533241567587 7.397991678155111 0.9999999999210156 5.55612663389191 0.8964796584827485 0.7298475554586842 0.0 2.9800125510559025e-17 0.7066718568863357 0.23555728562877853 2.961193302430245e-10 9.528533241567587 4.556126633970894 NPSAAFFCVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPSAAFFCVAR 11 0 O75223;B8ZZK2;O75223-3;O75223-2;O75223-4;A0A0B4J1Y4 O75223 GGCT Gamma-glutamylcyclotransferase 0 39200000.0 10563000.0 12177000.0 16460000.0 False True 13848195.292237516 10360239.06557424 14756877.095469039 1.0 0.7481291855684314 1.0656173446471306 23.723194639577248 -6.695253822289189 1.8473701679643395 0.8428839660842937 1.0646076855918902 0.39534102950903016 0.10641178013536813 0.4054463097316471 2.6865424182010855 0.046008446491849285 0.11903845113217766 2.0171870793174125e-07 6.695253822289189 0.2217237195075965 NPSAAFFCVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPSAAFFCVAR 11 0 O75223;B8ZZK2;O75223-3;O75223-2;O75223-4;A0A0B4J1Y4 O75223 GGCT Gamma-glutamylcyclotransferase 0 35656000.0 10563000.0 11800000.0 13293000.0 False True 14468426.554341696 11278636.982618168 10153467.177928621 1.0 0.7795344531941288 0.7017671990657313 23.78640470110014 -13.999999999999998 0.1452087816378954 2.0589685436932386 0.6113086534545883 0.9995830072202239 0.002579363214373579 11.942938055903008 0.11974342371505704 3.5745225365434847 0.08118488985076282 1.0000000000000041e-14 13.999999999999998 -1.4476598902386502 NPSLPSK(ub)LDPFESSDPFSSSSVSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPSLPSKLDPFESSDPFSSSSVSSK 25 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 177096000.0 38046000.0 82321000.0 56729000.0 True False 49878674.43798806 70039027.68474473 50859227.26299282 1.0 1.4041878312508314 1.0196587586990478 25.57191978921969 -10.53423906053445 6.662621870306528 0.9998328948438051 1.2119232949749443 0.2882480775107147 0.1569833365029204 0.0003899686941211323 2.7261312569277978e-05 0.15211731646537668 0.050666153992323784 2.922543199978375e-11 10.53423906053445 0.21209040013113922 NPSLPSK(ub)LDPFESSDPFSSSSVSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPSLPSKLDPFESSDPFSSSSVSSK 25 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 376212300.0 125173700.0 125668600.0 125370000.0 True False 121200129.41011938 175848727.33309156 92531835.98061913 1.0 1.4508955410274453 0.7634631780590604 26.852815998332517 -6.729742606054666 1.723967880495569 1.2714234695176132 0.7638769129364974 0.5581384456754832 0.1895500504679439 0.3367323339013738 1.9604863471097043 0.08713130189978047 0.21629001347101867 1.8631910696701734e-07 6.729742606054666 -0.5075465565811158 NPSLPSK(ub)LDPFESSDPFSSSSVSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPSLPSKLDPFESSDPFSSSSVSSK 25 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 467276800.0 186928800.0 180980000.0 99368000.0 True False 283584655.9258112 148682704.9968061 79727871.24545841 1.0 0.5242974254421688 0.2811431069328239 28.07920423307755 -9.653104016591444 0.17771600766162143 1.5756344295559475 8.75947872746704e-19 0.9996174659882149 0.0058391194914518725 1.101292049292829 0.07371240510013727 0.48329299876118015 0.1627009873155919 2.2227774560153196e-10 9.653104016591444 -1.5756344295559475 NPSLPSK(ub)LDPFESSDPFSSSSVSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPSLPSKLDPFESSDPFSSSSVSSK 25 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 213329400.0 38046000.0 79355600.0 95927800.0 True False 52112634.354490526 75849407.19812323 73271629.33505608 1.0 1.4554897893314296 1.4060242826458127 25.635129850742583 -10.448495253932093 5.980663824957447 0.9997832955169844 1.4307570359886213 0.9902067387401855 0.020194208541332245 5.837952178207303e-05 5.383412949620273e-06 0.019562619575683338 0.006517652780868219 3.560448809533421e-11 10.448495253932093 0.43097374047163683 NPSLPSK(ub)LDPFESSDPFSSSSVSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPSLPSKLDPFESSDPFSSSSVSSK 25 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 397881200.0 125173700.0 169205800.0 103501700.0 True False 104087477.68514085 168294254.7706783 125143426.93220946 1.0 1.6168540012061738 1.202290897189014 26.633221273766793 -10.103213991 4.579482277827196 0.9999685091129834 1.4095724491709336 0.5654864683642813 0.1692446785437343 117846411.38804844 1.4280668265848724 39798.152056844265 0.05793695510418889 7.884715163572874e-11 10.103213991 0.4096039400579502 NPSLPSK(ub)LDPFESSDPFSSSSVSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPSLPSKLDPFESSDPFSSSSVSSK 25 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 514096200.0 186928800.0 235674400.0 91493000.0 True False 241983016.51751998 222558912.46555254 74842212.797457 1.0 0.9197294738634638 0.30928704780419286 27.85033055517 -6.931052419424661 0.738111758849102 1.0089303136131311 0.18054434070242795 0.9967408682028303 0.01760796240408394 0.09209537034551933 0.07503266901326486 0.016143192706033097 0.05491851314230367 1.1720538898879457e-07 6.931052419424661 -0.8283859729107031 down NPSLPSKLDPFESSDPFSSSSVSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPSLPSKLDPFESSDPFSSSSVSSK 25 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 0 16702900.0 3834600.0 5307700.0 7560600.0 False True 3712872.7219539187 7427092.289289843 5580252.046861839 1.0 2.000362750216037 1.5029473038130976 21.82410442947961 -10.178972059912185 4.761310999900338 0.9999073491949577 1.7516550270183346 0.7527598008719601 0.20306900565726813 0.0001997443355391652 3.444348973751684e-05 0.1966447464949794 0.06554023975162057 6.622591083933244e-11 10.178972059912185 0.7517476778233769 NPSLPSKLDPFESSDPFSSSSVSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPSLPSKLDPFESSDPFSSSSVSSK 25 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 0 12748200.0 3834600.0 4842500.0 4071100.0 False True 3188639.801583245 4816412.491339009 4922348.187360384 1.0 1.5104912411077387 1.5437140892854395 21.604509704913887 -11.594586198547445 0.44474818482291223 6.036680436516411e-10 1.544057934540912 0.9997799602665998 0.0036913481631712336 4.357211412286842 0.22093839422685113 4.173844069144799 0.007584449860375432 2.5433949312992867e-12 11.594586198547445 1.544057933937244 NPSTNFQEPVQPLTQQQVAQMQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPSTNFQEPVQPLTQQQVAQMQLK 24 0 P19623;K7EL89 P19623 SRM Spermidine synthase 0 8256000.0 2218100.0 1312800.0 4725100.0 False True 2147687.629626554 1837007.886161561 3487454.560038477 1.0 0.8553422112325455 1.623818339282834 21.034352745161527 -6.858031045694543 1.1957583667033598 0.9218942040092791 1.659634638616399 0.9511855712009949 0.07366984796365812 0.1488483597256124 0.405559047373016 0.048090867675421076 0.11201294468021551 1.3866566996844892e-07 6.858031045694543 0.7377404346071198 NPSTNFQEPVQPLTQQQVAQMQLK(ub)YYNSDVHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPSTNFQEPVQPLTQQQVAQMQLKYYNSDVHR 32 1 P19623;K7EL89 P19623 SRM Spermidine synthase 1 67456000.0 19363000.0 16006000.0 32087000.0 True False 18748332.16377032 22397279.27018734 23682452.11063352 1.0 1.1946278247335687 1.2631764737131121 24.16025892456244 -13.999999999999998 0.14543328976297448 0.06487745764104634 1.342702038747573 0.9995821867515514 0.0022786022259799563 11.943467225245696 0.11984945292264616 3.1612118785026064 0.0713858868008066 1.0000000000000041e-14 13.999999999999998 1.2778245811065267 NPSTNFQEPVQPLTQQQVAQMQLK(ub)YYNSDVHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPSTNFQEPVQPLTQQQVAQMQLKYYNSDVHR 32 1 P19623;K7EL89 P19623 SRM Spermidine synthase 1 196807000.0 43686000.0 54040000.0 99081000.0 True False 66274855.8744025 44396139.7835528 79497596.92125504 1.0 0.669879084576026 1.1995136899567305 25.98195829192933 -6.73816577082801 1.6933838272064543 0.8031577575893774 1.199701521312319 0.5966300693445126 0.1387107478324498 0.32117557267482916 1.8076386989913928 0.06481984458770833 0.15938518596219872 1.8274025608189677e-07 6.73816577082801 0.39654376372294164 NPSTNFQEPVQPLTQQQVAQMQLK(ub)YYNSDVHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPSTNFQEPVQPLTQQQVAQMQLKYYNSDVHR 32 1 P19623;K7EL89 P19623 SRM Spermidine synthase 1 67638000.0 19363000.0 21875000.0 26400000.0 True False 16101192.426343381 21757155.033152465 31920117.940191627 1.0 1.351276008449864 1.9824691920311868 23.940664199996718 -6.962084162962005 0.4049915117840995 0.9671562056053756 2.3898232947243936 0.9998398574425639 0.005143917126184643 0.07896484758841775 0.018440987449127963 0.008120588103505577 0.052788601206115456 1.0912288441199419e-07 6.962084162962005 1.422667089119018 NPSTNFQEPVQPLTQQQVAQMQLK(ub)YYNSDVHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPSTNFQEPVQPLTQQQVAQMQLKYYNSDVHR 32 1 P19623;K7EL89 P19623 SRM Spermidine synthase 1 207642000.0 43686000.0 46836000.0 117120000.0 True False 56552388.17980107 44229535.42784709 95805361.75268237 1.0 0.7820984551036987 1.6940993092649157 25.75308461402178 -6.843665292722061 1.2653986141701343 0.8840832443225942 1.7263125312188328 0.930551346662965 0.10248016128214917 0.16456441517291354 0.5102922983213093 0.06346469697172404 0.14637510110209434 1.4332921004586728e-07 6.843665292722061 0.8422292868962385 NPTIVNFPITNVDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPTIVNFPITNVDLR 15 0 A0A087X1B2;B9A018;Q53GS9;Q53GS9-2 A0A087X1B2 USP39 U4/U6.U5 tri-snRNP-associated protein 2 0 5155000.0 1403200.0 1895800.0 1856000.0 False True 1839608.7886081315 1612954.0297705214 1663958.9240091427 1.0 0.8767918699664946 0.9045178161320443 20.81096756455033 -10.405021914798255 5.889954026583436 1.000034229927842 0.8906548430492695 0.9539974165604029 0.011319070123579075 5.089401099159378e-06 5.141049495547421e-07 0.010963071015950907 0.003653214173597924 3.9353021714933145e-11 10.405021914798255 -0.10937938687857252 NPTIVNFPITNVDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPTIVNFPITNVDLR 15 0 A0A087X1B2;B9A018;Q53GS9;Q53GS9-2 A0A087X1B2 USP39 U4/U6.U5 tri-snRNP-associated protein 2 0 5262000.0 1620400.0 1347500.0 2294100.0 False True 1568961.288962116 1885563.7771196682 1693206.3884752204 1.0 1.2017911406641448 1.079189397716303 20.581378326403065 -10.282458871102534 4.010589637709959 0.9998142400032285 1.1404902692020618 0.6364701325724815 0.05005195200715879 35469885.64676087 18.769594570366436 60977.041238604 0.017134114469995135 5.218445220291614e-11 10.282458871102534 0.14067602919883326 NPTIVNFPITNVDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPTIVNFPITNVDLR 15 0 A0A087X1B2;B9A018;Q53GS9;Q53GS9-2 A0A087X1B2 USP39 U4/U6.U5 tri-snRNP-associated protein 2 0 7024000.0 1403200.0 2612300.0 3008500.0 False True 1922000.9600541776 2496879.948279104 2297954.2620024295 1.0 1.2991044230325055 1.1956051582501055 20.874177626073223 -10.080822752143376 4.27117396574013 0.9999718884016079 1.2473547906101567 0.8839316438422221 0.04225339804840243 14678085.33131046 0.11328438011037284 4234.329634646362 0.014464462006253922 8.301895221975197e-11 10.080822752143376 0.24738290220854886 NPVFDDEEK(ub)SK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPVFDDEEKSK 11 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 18031400.0 3541600.0 8193700.0 6296100.0 True False 4643071.896903193 6971231.898792449 5644639.968455804 1.0 1.5014266532125162 1.2157123761578257 22.146648190203464 -10.132721426002645 4.688685143499802 0.9999692272238947 1.3585695146894397 0.6774205033027143 0.11664236518334722 3.752518514742287e-05 6.94112186840734e-06 0.11294816433738697 0.03764616148270537 7.366794819079672e-11 10.132721426002645 0.35860028746554495 NPVFDDEEK(ub)SK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPVFDDEEKSK 11 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 24270100.0 5316400.0 7396900.0 11556800.0 True False 5147633.792050231 10350520.74432391 8529727.383431597 1.0 2.0107337006585 1.6570190747843243 22.295477991727882 -10.108199112496486 4.851525891936939 0.9999743278996619 1.8338763877231405 0.8810982401366594 0.14440339155999438 100598838.92460577 3.096240190105988 44176.01449872489 0.04943312179870426 7.794726610562203e-11 10.108199112496486 0.8339020598234786 NPVFDDEEK(ub)SK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPVFDDEEKSK 11 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 48449000.0 10942000.0 15946000.0 21561000.0 True False 16599813.96735136 13100311.713333348 17299458.89947799 1.0 0.78918424863671 1.0421477574087694 23.984663737718463 -6.685526320143723 1.8821605730074116 0.8672824681597349 1.0412327947364883 0.349621213654282 0.08924274595137076 0.42636733393855436 2.924756514019056 0.03798039874858318 0.0994704981080294 2.0628786440604564e-07 6.685526320143723 0.17395032657675347 NPVFDDEEK(ub)SK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPVFDDEEKSK 11 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 14392300.0 3541600.0 3383300.0 7467400.0 True False 4851025.228141303 3233814.618923053 5703753.915930503 1.0 0.6666249847894745 1.17578318967348 22.209858251726356 -6.730065439759828 1.722929033025085 0.7993840335522332 1.1754848339443285 0.5595070966420663 0.1401433012716584 0.33616013827289204 1.9549709362178984 0.06445674470703357 0.15993700172258624 1.8618065773650115e-07 6.730065439759828 0.37610080039209526 NPVFDDEEK(ub)SK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPVFDDEEKSK 11 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 17672600.0 5316400.0 8032000.0 4324200.0 True False 4420822.15645365 7988730.021772826 5228370.227158204 1.0 1.8070688525912846 1.1826692054385564 22.07588326716216 -10.457412376213034 5.476980193001811 0.9994718605590529 1.4948690290149222 0.455787551526179 0.25491008851634767 0.001645592763124901 0.00016302384960210833 0.24706799133911744 0.08227187730033836 3.488089531580199e-11 10.457412376213034 0.49539716845586934 NPVFDDEEKSK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPVFDDEEKSK 11 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 30045800.0 7220600.0 16108000.0 6717200.0 True False 9347209.039304843 15211575.639929999 5494738.524292328 1.0 1.6273922596537214 0.587848041183957 23.156104227776144 -6.743309107392648 1.6747717814718484 1.3718553142726433 0.5868055700090766 0.6196668773871612 0.26359097907050705 0.31183881440337424 1.7186540936615207 0.12445392349405063 0.304273956145368 1.8058883345536918e-07 6.743309107392648 -0.7850497442635667 NPVGYPLAWQFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPVGYPLAWQFLR 13 0 Q9NZ08;Q9NZ08-2;H0Y9X5 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 3208600.0 667700.0 1202900.0 1338000.0 False True 875361.1660159973 1023432.0088674757 1199556.5950022829 1.0 1.1691540002001555 1.370356193046335 19.739518856998576 -6.9688250590420875 0.2848527731340662 0.9581858028997474 1.5874964757300392 0.9999717119347395 0.0008051480963714368 0.07668580028871848 0.010388190085698598 0.0036155921977034065 0.018357396104311956 1.0744221200799465e-07 6.9688250590420875 0.6293106728302917 NPVGYPLAWQFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPVGYPLAWQFLR 13 0 Q9NZ08;Q9NZ08-2;H0Y9X5 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 4382500.0 667700.0 1663000.0 2051800.0 False True 914566.7339140339 1589523.161194406 1567207.0981474423 1.0 1.7380067547305036 1.7136060606975394 19.802728918521467 -10.189884434923172 4.437748432306345 0.9998156158192136 1.7258064077297972 0.999153053073332 0.009961541681804815 1115318.7450534198 2560982.123678692 1220.5579016541096 0.0034101007583871236 6.458260594678071e-11 10.189884434923172 0.7259907919105836 NPVIAQK(ub)IQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPVIAQKIQK 10 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 3045940.0 1069100.0 863040.0 1113800.0 True False 1035162.0056957537 1207656.3726941438 822062.3667162281 1.0 1.1666351412139138 0.7941388518830953 19.981425140453236 -6.785106452693045 1.5159898706768424 1.0937282443888716 0.7907025470803987 0.7850316090778857 0.07063741831466101 0.2427235753539217 1.1020600136123968 0.03668808328481869 0.08620596366975555 1.6401876870474837e-07 6.785106452693045 -0.30302569730847295 NPVIAQK(ub)IQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPVIAQKIQK 10 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 6994900.0 2705500.0 2435300.0 1854100.0 True False 4104441.2985440562 2000701.6879142518 1487636.3223191025 1.0 0.48744799654558313 0.36244551063424946 21.968754423318334 -13.999999999999998 0.19819147313130947 3.8298342622398405 0.2798011160657012 0.9994869442445492 0.006248074158176739 12.495733753981034 0.14116845630889202 13.697381634898301 0.0806819972499349 1.0000000000000041e-14 13.999999999999998 -3.5500331461741395 NPVIAQK(ub)IQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPVIAQKIQK 10 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 3222030.0 1069100.0 1620300.0 532630.0 True False 889004.0191604468 1611571.122295632 644000.4703971306 1.0 1.8127827181451435 0.7244067029137939 19.761830415887513 -6.706800168284312 1.8066787596394405 1.5013058543314486 0.7272033967801877 0.4498777245539778 0.3426783844346172 0.38153556522016024 2.425594751447025 0.15105813790644398 0.38524537722947594 1.964263884749161e-07 6.706800168284312 -0.7741024575512608 NPVTIFSLATNEMWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPVTIFSLATNEMWR 15 0 Q04837;A0A0G2JLD8;E7EUY5;C9K0U8 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 0 4679400.0 1917400.0 1571700.0 1190300.0 False True 1856533.1865316953 2199288.0063072224 878524.721765422 1.0 1.1846208956899116 0.47320711966730233 20.82417967369904 -6.837803645565034 1.2926398786690587 1.0982573002719531 0.4508190640407064 0.9205972609454982 0.08493659748230495 0.17138048367720032 0.5572228043971483 0.051542733722821484 0.1186783585241808 1.4527682987898695e-07 6.837803645565034 -0.6474382362312467 down NPVTIFSLATNEMWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPVTIFSLATNEMWR 15 0 Q04837;A0A0G2JLD8;E7EUY5;C9K0U8 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 0 56938000.0 12242000.0 23824000.0 20872000.0 False True 18572009.010081813 19572421.062238384 16746640.051477412 1.0 1.0538666577004943 0.9017139740986826 24.146626550142447 -6.811016940733202 1.4102991402275087 1.029321913034995 0.8989910094732977 0.8624485950457497 0.023362512383588913 0.20542204628120236 0.8050750471855557 0.013025030194502497 0.03011529212778086 1.5451941642327794e-07 6.811016940733202 -0.1303309035616974 NPVTIFSLATNEMWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPVTIFSLATNEMWR 15 0 Q04837;A0A0G2JLD8;E7EUY5;C9K0U8 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 0 25266000.0 12242000.0 0.0 13024000.0 False True 15847510.325896708 0.0 10653765.637525054 1.0 0.0 0.6722674677873873 23.917752872234896 -10.399686930494246 7.931526791892254 1.0000114995648453 0.3361337338936937 0.5652583556626756 0.27445204445867094 5.581019569654754e-05 4.224274599376661e-06 0.26574163889988744 0.08857901646008418 3.9839425720542704e-11 10.399686930494246 -0.6638777656711515 NPWTGVSQFLQTSQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPWTGVSQFLQTSQK 15 0 I3L1R7;Q99447;I3L1L9;Q99447-4;Q99447-3;I3L2Q1;Q99447-2;I3L3V9 I3L1R7 PCYT2 Ethanolamine-phosphate cytidylyltransferase 0 5601780.0 968380.0 2098300.0 2535100.0 False True 1269555.5578052604 1785241.8191093376 2272792.170396328 1.0 1.4061943237801802 1.7902266320076683 20.275892100360238 -6.971804454444927 0.21067495161372254 0.8006600252621962 2.406489806965541 0.999993245222079 0.0008385485347568809 0.07572140265118225 0.0068943478612931075 0.011438608178768987 0.03973315712161826 1.0670764752326189e-07 6.971804454444927 1.6058297817033451 NPWTGVSQFLQTSQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPWTGVSQFLQTSQK 15 0 I3L1R7;Q99447;I3L1L9;Q99447-4;Q99447-3;I3L2Q1;Q99447-2;I3L3V9 I3L1R7 PCYT2 Ethanolamine-phosphate cytidylyltransferase 0 5374680.0 968380.0 1920100.0 2486200.0 False True 1326416.255485507 1835263.633078399 1899010.7648962736 1.0 1.3836257098693647 1.4316853831086234 20.33910216188313 -12.079262124879428 0.32968978451988373 1.1200332543411374e-15 1.4409467875611672 0.9995658384241303 0.00402498420453514 5.565094288575164 0.17662493933552756 3.821285575675604 0.015410167058564099 8.331781557894627e-13 12.079262124879428 1.4409467875611661 NPWVQIMMFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPWVQIMMFK 10 0 E7EPW2;P82663-3;P82663-2;P82663 E7EPW2 MRPS25 28S ribosomal protein S25, mitochondrial 0 4914700.0 1378000.0 2383200.0 1153500.0 False True 1806571.3445709848 2027635.8496408383 1034146.8851533111 1.0 1.1223668833972071 0.5724362274764714 20.784822799697253 -6.848313229691934 1.2431709394402606 1.0652173540546912 0.5511529771459758 0.9378220407694459 0.05878579032850974 0.15931929895358005 0.47466291079019457 0.037017395674841885 0.08557493811882211 1.4180344124498244e-07 6.848313229691934 -0.5140643769087154 NPWVQIMMFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPWVQIMMFK 10 0 E7EPW2;P82663-3;P82663-2;P82663 E7EPW2 MRPS25 28S ribosomal protein S25, mitochondrial 0 19601200.0 5714900.0 5469500.0 8416800.0 False True 8669921.115154108 4493424.991601453 6753215.790785515 1.0 0.5182774943300719 0.7789247100508914 23.04758743620915 -10.095110575750109 5.226500177584105 1.0000065523284334 0.6486011021900209 0.7078966622353569 0.10640878023379957 8.124417189236943e-06 1.4066561052950884e-06 0.10303177918218105 0.03434328614441411 8.033215623829075e-11 10.095110575750109 -0.3514054501384125 NPWVQIMMFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPWVQIMMFK 10 0 E7EPW2;P82663-3;P82663-2;P82663 E7EPW2 MRPS25 28S ribosomal protein S25, mitochondrial 0 9802600.0 1378000.0 2789600.0 5635000.0 False True 1887483.8390497842 2666346.248026404 4304129.056467898 1.0 1.412645868993889 2.2803527995422335 20.848032861220144 -6.959053424667425 0.4485832337926425 0.9716094911513775 2.7557060254907033 0.9997334412065162 0.00871177577710492 0.08004112601325525 0.022394671510781908 0.011573616369623138 0.07178897907458869 1.0988706537170309e-07 6.959053424667425 1.7840965343393258 up NPWVQIMMFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPWVQIMMFK 10 0 E7EPW2;P82663-3;P82663-2;P82663 E7EPW2 MRPS25 28S ribosomal protein S25, mitochondrial 0 17748400.0 5714900.0 5898900.0 6134600.0 False True 7398050.707520595 5570621.029450159 5018165.746311516 1.0 0.7529849753242788 0.6783091850411659 22.818713758301598 -13.999999999998714 0.16761124876130565 2.2381068156706987 0.6107330789194608 0.9995184395843634 0.003016666170199476 12.069142984970306 0.1295941211065889 4.857573467433699 0.06223211673333501 1.0000000000029614e-14 13.999999999998714 -1.6273737367512378 NPYYGGESASITPLEDLYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPYYGGESASITPLEDLYK 19 0 P50395;P50395-2;Q5SX87;V9GYJ7;V9GYF8;Q5SX90 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 13808500.0 1140800.0 6222100.0 6445600.0 False True 1495599.8475229146 5293786.933555835 5778671.1425610725 1.0 3.539574400414431 3.863781580435428 20.512292798549485 -10.048709046060498 0.47822187056934273 1.863834789067759e-18 3.862422789809065 0.9991915706855613 0.036406677683218695 1.349036617592413 0.21855105156150254 1.99131243559505 0.06847381511917705 8.93904150865991e-11 10.048709046060498 3.862422789809065 NPYYGGESASITPLEDLYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPYYGGESASITPLEDLYK 19 0 P50395;P50395-2;Q5SX87;V9GYJ7;V9GYF8;Q5SX90 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 17237000.0 5802000.0 1883700.0 9551300.0 False True 5617818.685854232 2635871.2333657322 7049527.99714197 1.0 0.469198345614625 1.2548514630585725 22.42157863180199 -6.724712401304869 1.7422257824467684 0.6787013415701081 1.253973923852805 0.5346815666897886 0.22324474101743075 0.3462583681760462 2.056402931093986 0.10164305196011911 0.25377158054263615 1.8848968935868237e-07 6.724712401304869 0.5752725822826968 NPYYGGESASITPLEDLYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPYYGGESASITPLEDLYK 19 0 P50395;P50395-2;Q5SX87;V9GYJ7;V9GYF8;Q5SX90 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 13817900.0 1140800.0 4482300.0 8194800.0 False True 1562584.588960806 4284257.165016048 6259357.017203747 1.0 2.741776154253054 4.005771630812333 20.575502860072376 -7.931570597154145 0.21272657753608298 4.2013806808263424e-17 5.533964917381371 0.9998075429414753 0.017094974030804205 0.11498735025499222 0.036340201594177286 0.3191230833423161 0.4551920338772974 1.1706562897015896e-08 7.931570597154145 5.533964917381371 NPYYGGESASITPLEDLYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPYYGGESASITPLEDLYK 19 0 P50395;P50395-2;Q5SX87;V9GYJ7;V9GYF8;Q5SX90 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 8715500.0 5802000.0 1357100.0 1556400.0 False True 4824620.072181189 1349789.0329367414 1881836.044019478 1.0 0.2797710519673123 0.3900485459715604 22.201983907236265 -10.116007341443732 5.440560076707149 1.0000103149009198 0.3349097989864955 0.9797972647965867 0.04502059840470793 5.632871667028475e-06 9.15283577264115e-07 0.04359168175994915 0.01453033565468962 7.655836651467641e-11 10.116007341443732 -0.6651005159144243 NPYYGGESASITPLEDLYK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 NPYYGGESASITPLEDLYKR 20 1 P50395;P50395-2;Q5SX87;V9GYJ7;V9GYF8;Q5SX90 P50395 GDI2 Rab GDP dissociation inhibitor beta 1 9305500.0 1568400.0 2864000.0 4873100.0 True False 2056187.5884072054 2436702.363784562 4368878.358075952 1.0 1.185058395217781 2.124746974793403 20.971540458622187 -6.939462247573346 0.6645561365526443 0.9893483260923623 2.3741848803836185 0.9980925061987245 0.021506474059256746 0.08801297106363909 0.055735125351749064 0.02085051024885481 0.08107070594430617 1.1495761696348345e-07 6.939462247573346 1.3848365542912562 up NPYYGGESASITPLEDLYK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 NPYYGGESASITPLEDLYKR 20 1 P50395;P50395-2;Q5SX87;V9GYJ7;V9GYF8;Q5SX90 P50395 GDI2 Rab GDP dissociation inhibitor beta 1 26103500.0 4954900.0 6179600.0 14969000.0 True False 4797609.411675137 8647146.50618827 11048169.839625802 1.0 1.8023865146556453 2.302848959054425 22.193884277439718 -8.70334342201909 0.149055157877161 4.0965231263765055e-24 3.2042615177888365 0.999876797074488 0.00595636906143182 0.2654772490496344 0.042173656093115686 0.46725377159999487 0.3532991858058367 1.979960735981543e-09 8.70334342201909 3.2042615177888365 NPYYGGESASITPLEDLYK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 NPYYGGESASITPLEDLYKR 20 1 P50395;P50395-2;Q5SX87;V9GYJ7;V9GYF8;Q5SX90 P50395 GDI2 Rab GDP dissociation inhibitor beta 1 70217200.0 9873200.0 17703000.0 42641000.0 True False 14978366.22760495 14543761.335829701 34212987.6597858 1.0 0.9709844928898669 2.284160177411851 23.83637693394445 -6.901847975485708 0.9495066482998673 0.9481367125712342 2.427294502541175 0.987463609774006 0.06855819764368472 0.11005793212435076 0.1698454949649303 0.05395912900813713 0.1417406770985429 1.253579913018746e-07 6.901847975485708 1.4791577899699409 up NPYYGGESASITPLEDLYK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NPYYGGESASITPLEDLYKR 20 1 P50395;P50395-2;Q5SX87;V9GYJ7;V9GYF8;Q5SX90 P50395 GDI2 Rab GDP dissociation inhibitor beta 1 11545800.0 1568400.0 2756800.0 7220600.0 True False 2148279.864416312 2634995.4604815003 5515242.992924955 1.0 1.2265606097822963 2.5672832875633955 21.034750520145078 -6.93612857711833 0.6946532951375591 0.9834796762253868 2.8910537473905653 0.9976114734309526 0.03380202027326796 0.08957812606335214 0.06299196497859072 0.032008140872257757 0.11749553885795144 1.158434339593048e-07 6.93612857711833 1.9075740711651785 up NPYYGGESASITPLEDLYK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NPYYGGESASITPLEDLYKR 20 1 P50395;P50395-2;Q5SX87;V9GYJ7;V9GYF8;Q5SX90 P50395 GDI2 Rab GDP dissociation inhibitor beta 1 22939100.0 4954900.0 6202200.0 11782000.0 True False 4120218.889288277 6168787.517559687 14245561.72618701 1.0 1.4971989797914056 3.45747692270004 21.974289552873994 -6.945206553597537 0.6092020439575108 0.9782918163570072 4.078329540762841 0.9987693863670689 0.03721558072533682 0.08546957530207597 0.04438196715740209 0.037857408271501636 0.1652494562177737 1.1344711246676855e-07 6.945206553597537 3.1000377244058335 up NPYYGGESASITPLEDLYK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NPYYGGESASITPLEDLYKR 20 1 P50395;P50395-2;Q5SX87;V9GYJ7;V9GYF8;Q5SX90 P50395 GDI2 Rab GDP dissociation inhibitor beta 1 64899200.0 9873200.0 10189000.0 44837000.0 True False 12781052.029867947 9621973.193149172 36677126.066470385 1.0 0.7528310792150484 2.869648443708693 23.6075032560369 -6.877805298386037 1.0920122650105746 0.8508479159771373 3.013465712349451 0.9718695372507221 0.15850034180992112 0.1295897290763789 0.2842107297135966 0.1120239334177367 0.2694450193602725 1.324935393171961e-07 6.877805298386037 2.162617796372314 up NQAAQAAK(ub)PEDPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQAAQAAKPEDPR 13 1 Q9NYZ3 Q9NYZ3 GTSE1 G2 and S phase-expressed protein 1 1 2164600.0 461140.0 847110.0 856350.0 True False 604559.0056861121 720724.4900089183 767743.1166892399 1.0 1.1921491256109409 1.2699225542392354 19.20552362955446 -13.999999999999998 0.12455003734505611 0.08639245570580913 1.3867713886551938 0.9996709377345833 0.002057894898988549 11.948573067389102 0.10917297391040155 2.6870848171683637 0.10375375170891242 1.0000000000000041e-14 13.999999999999998 1.3003789329493847 NQAAQAAK(ub)PEDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQAAQAAKPEDPR 13 1 Q9NYZ3 Q9NYZ3 GTSE1 G2 and S phase-expressed protein 1 1 7799650.0 768250.0 2455200.0 4576200.0 True False 1165491.416598216 2017050.3774348428 3671712.0641802894 1.0 1.730643699909965 3.150355302398638 20.152506948928846 -6.960605410659059 0.42681550045938726 0.9416647084201031 3.9934927879026274 0.999791998699507 0.012875844990187301 0.07948555766817621 0.020337424396217788 0.018459165540522085 0.1179697937373443 1.094950759934556e-07 6.960605410659059 3.051828079482524 NQALNIAWQK(ub)VNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQALNIAWQKVNK 13 1 O95347;O95347-2;A0A0C4DGE5 O95347 SMC2 Structural maintenance of chromosomes protein 2 1 26894700.0 2344000.0 7225700.0 17325000.0 True False 3556019.369354008 5936217.380348217 13900706.156182753 1.0 1.6693433763344767 3.9090636783308566 21.76183175175813 -6.948973459038486 0.5700013346760252 0.9721002153166722 4.715200796602072 0.9991182493730474 0.03693862401617797 0.08390057489245303 0.03768852795655606 0.03913414859114931 0.18661278445400567 1.1246737038510159e-07 6.948973459038486 3.7431005812853995 NQALNIAWQK(ub)VNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NQALNIAWQKVNK 13 1 O95347;O95347-2;A0A0C4DGE5 O95347 SMC2 Structural maintenance of chromosomes protein 2 1 21314800.0 2344000.0 2974800.0 15996000.0 True False 3034354.2071476784 2809249.764940639 13084892.132820228 1.0 0.925814711520235 4.312249407797434 21.53295807385058 -6.90189473079195 0.9492371743496674 0.866430463743216 4.681680892903518 0.9874849150302092 0.1766648011707195 0.11002318977798138 0.16966909429736612 0.13907567186127454 0.3654047755642591 1.2534449622876503e-07 6.90189473079195 3.815250429160302 up NQAPPGLYTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQAPPGLYTK 10 0 P00966 P00966 ASS1 Argininosuccinate synthase 0 11874200.0 2940200.0 1750500.0 7183500.0 False True 2846864.9603841086 2449483.7787369033 5301925.849619345 1.0 0.8604144604057408 1.8623734962490075 21.440942630509475 -6.871650784925799 1.125261416364439 0.920201116156152 1.9229405813696816 0.9663063737995264 0.08133593375804254 0.13528521740829103 0.31914198925636356 0.05603606213926201 0.1330678741714537 1.3438451091982295e-07 6.871650784925799 1.0027394652135295 NQDDFECVTTLEGHENEVK(ub)SVAWAPSGNLLATCSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSR 35 1 O76071 O76071 CIAO1 Probable cytosolic iron-sulfur protein assembly protein CIAO1 1 50161200.0 7894200.0 15738000.0 26529000.0 True False 11976078.54332527 12929430.938444762 21285531.521926217 1.0 1.079604721334333 1.7773373349984802 23.513652252451823 -6.92843681041059 0.7595064231149992 0.988752201105094 1.9150417373296644 0.9962222405307894 0.021462609457730698 0.09345711748928831 0.08171394626888275 0.019374851187829098 0.06368374505018229 1.1791340740713001e-07 6.92843681041059 0.9262895362245704 NQDLAPNSAEQASILSLVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQDLAPNSAEQASILSLVTK 20 0 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 39954400.0 2543400.0 24510000.0 12901000.0 False True 3334422.0303206346 20853203.539231718 11566128.275130358 1.0 6.253918475108712 3.4687055717473685 21.669005283881848 -9.545914512001085 9.062760777283808 1.000007232823095 4.861312023428043 0.7193111979408823 1.1370584063828442 0.0 0.0 1.1009520842983493 0.3669840226310011 2.845021075931764e-10 9.545914512001085 3.8613047906049482 NQDLAPNSAEQASILSLVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQDLAPNSAEQASILSLVTK 20 0 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 39609300.0 12478000.0 8700300.0 18431000.0 False True 12081892.720111862 12174375.161465133 13603368.181852043 1.0 1.0076546318938358 1.1259302244264666 23.526343145697542 -6.920068212370237 0.8242311161921276 0.9973967134207833 1.1450325242266621 0.9941995965528545 0.00439023315981058 0.0981316690518066 0.1054098947983402 0.0037839939526604126 0.011342080107161576 1.202075616038998e-07 6.920068212370237 0.14763581080587884 NQDLAPNSAEQASILSLVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQDLAPNSAEQASILSLVTK 20 0 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 40352400.0 2543400.0 14758000.0 23051000.0 False True 3483763.71280059 14105942.761820244 17606828.550246965 1.0 4.049052669671592 5.053967490835616 21.73221534540474 -9.303015277194422 0.3658334826183724 7.019044806903454e-23 5.276603564234309 0.9981873257050796 0.07338871925904195 0.6863612648036849 0.14271404371682272 1.2224993622047433 0.2784654579524659 4.97719576369471e-10 9.303015277194422 5.276603564234309 NQDLAPNSAEQASILSLVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQDLAPNSAEQASILSLVTK 20 0 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 21741000.0 12478000.0 4369700.0 4893300.0 False True 10376009.869127337 4346159.558782465 5916466.405937105 1.0 0.4188661743387484 0.5702063202099386 23.306748421131818 -10.41629981967644 9.067181341095063 1.0000025773573253 0.49453624727454965 0.9370015535494672 0.061784355830465036 3.2190279488796934e-06 2.0724640404472457e-07 0.05982274999078207 0.019940815098962016 3.8344244065232634e-11 10.41629981967644 -0.5054663300827757 NQDNLQGWNK(ub)TMDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQDNLQGWNKTMDGK 15 1 P30085;P30085-3;Q5T0D2;P30085-2;A0A494BXC7 P30085 CMPK1 UMP-CMP kinase 1 11167900.0 2446700.0 4180400.0 4540800.0 True False 3207647.393876505 3556700.615071573 4070961.5744292717 1.0 1.1088190746468645 1.2691424818703139 21.613084129114277 -6.965554114489857 0.3484141360151637 0.98422122343288 1.399137051659789 0.9999241107488803 0.0009629940010669076 0.07777344318071655 0.014199929456709027 0.002209722296846079 0.013794849808903296 1.0825448181555733e-07 6.965554114489857 0.414915828226909 NQDNLQGWNK(ub)TMDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQDNLQGWNKTMDGK 15 1 P30085;P30085-3;Q5T0D2;P30085-2;A0A494BXC7 P30085 CMPK1 UMP-CMP kinase 1 12128400.0 4349000.0 2504900.0 5274500.0 True False 4210943.37552224 3505119.6328809336 3892950.218391769 1.0 0.8323834638232886 0.9244841051582572 22.00571204506806 -10.093801740603828 4.446627025129328 1.0000113576171452 0.8784337844836081 0.699062264344138 0.037599929399916014 52313476.45717583 0.6319866253811514 6083.451100165771 0.01287145592947549 8.057461877441585e-11 10.093801740603828 -0.12157757313353712 NQDNLQGWNK(ub)TMDGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQDNLQGWNKTMDGK 15 1 P30085;P30085-3;Q5T0D2;P30085-2;A0A494BXC7 P30085 CMPK1 UMP-CMP kinase 1 35227300.0 8225300.0 11378000.0 15624000.0 True False 12478381.44997763 9347507.00328025 12535909.551757537 1.0 0.7490961100004686 1.004610221446629 23.572927480981935 -10.994852076644099 10.161965878640107 1.1091717399628012 0.8768531657209253 0.23647229199715925 0.10431319918728797 0.06546709314128055 3.3164775772844885e-05 0.02562827367275208 0.033666940270165265 1.011924063091628e-11 10.994852076644099 -0.23231857424187585 NQDNLQGWNK(ub)TMDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQDNLQGWNKTMDGK 15 1 P30085;P30085-3;Q5T0D2;P30085-2;A0A494BXC7 P30085 CMPK1 UMP-CMP kinase 1 9606700.0 2446700.0 3957500.0 3202500.0 True False 3351311.1095813517 3782644.5642975685 2446135.457557842 1.0 1.1287058827463199 0.7299040219108202 21.67629419063717 -6.819834773790315 1.3726046492787873 1.069382829549898 0.7212294878824123 0.8840023758236051 0.05660031923499097 0.19369427588023053 0.7171120875448734 0.03240466960690143 0.07469027596852652 1.5141371884396006e-07 6.819834773790315 -0.3481533416674857 NQDNLQGWNK(ub)TMDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQDNLQGWNKTMDGK 15 1 P30085;P30085-3;Q5T0D2;P30085-2;A0A494BXC7 P30085 CMPK1 UMP-CMP kinase 1 12853500.0 4349000.0 4990100.0 3514400.0 True False 3616386.193367111 4963217.3408427015 4249244.791250351 1.0 1.37242459058876 1.1749975152111738 21.786117320502335 -10.145050103862403 4.12668581422313 0.9999309580761906 1.2737110527833853 0.7193196774546313 0.08059926647334215 26565672.348953016 3.2550663313892167 20478.666020243287 0.029083755046719076 7.160607946544231e-11 10.145050103862403 0.27378009470719467 NQDNLQGWNK(ub)TMDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NQDNLQGWNKTMDGK 15 1 P30085;P30085-3;Q5T0D2;P30085-2;A0A494BXC7 P30085 CMPK1 UMP-CMP kinase 1 44605100.0 10988400.0 10460900.0 23155800.0 True False 14224700.413746411 9878741.719129859 18941681.99857208 1.0 0.6944780158310595 1.331604986229959 23.76189493247951 -6.776286963146903 1.5500955317996346 0.826171558352448 1.3360978180050316 0.7541100782791296 0.12901553408241997 0.2563886860280236 1.2164895557852486 0.06556903534805124 0.15521802671021623 1.6738365112482313e-07 6.776286963146903 0.5099262596525835 NQDRPSLLK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQDRPSLLKK 10 2 Q96G23;Q5SZE3;H0YKH6;Q5SZE4;Q5SZE1;H0YNU7 Q96G23 CERS2 Ceramide synthase 2 1 7303260.0 812090.0 862370.0 5628800.0 True False 1064657.8542907475 733707.7574919309 5046385.771262209 1.0 0.6891488702543893 4.739913157005735 20.02195843993984 -6.888375832763039 1.0319092839611435 0.7737986698181101 5.077471201362203 0.9798394342719823 0.2613514909369619 0.12047219817755139 0.22960770087401516 0.1933721128090872 0.47936047444257496 1.2930763457682653e-07 6.888375832763039 4.303672531544093 up NQDRPSLLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQDRPSLLKK 10 2 Q96G23;Q5SZE3;H0YKH6;Q5SZE4;Q5SZE1;H0YNU7 Q96G23 CERS2 Ceramide synthase 2 1 12313100.0 739900.0 1240200.0 10333000.0 True False 716412.2795007833 1735418.3275575594 7626477.316644642 1.0 2.4223737884097254 10.645374925676862 19.450430540156916 -6.936626236428846 0.6902362109360769 0.9001360377940493 12.658807922855853 0.9976877805551974 0.2044337268166097 0.08933999362508081 0.061874639442881726 0.19423973317244178 0.7188844199693774 1.1571076465883755e-07 6.936626236428846 11.758671885061805 NQDRPSLLK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQDRPSLLKK 10 2 Q96G23;Q5SZE3;H0YKH6;Q5SZE4;Q5SZE1;H0YNU7 Q96G23 CERS2 Ceramide synthase 2 1 8551250.0 812090.0 669560.0 7069600.0 True False 1112341.6189070672 639976.6252611704 5399906.0829823315 1.0 0.5753417964257962 4.854539281096051 20.085168501462732 -6.882496641919784 1.0658260939737063 0.727039501573839 5.172644324915471 0.9756421064760687 0.30042925634529183 0.12543934577814786 0.2591433194155852 0.2166312506827689 0.5273340218169901 1.310700177008585e-07 6.882496641919784 4.4456048233416325 up NQDRPSLLK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQDRPSLLKK 10 2 Q96G23;Q5SZE3;H0YKH6;Q5SZE4;Q5SZE1;H0YNU7 Q96G23 CERS2 Ceramide synthase 2 1 9534900.0 739900.0 1440700.0 7354300.0 True False 615259.6331276905 1432938.6631434392 8892050.127558758 1.0 2.328998338244707 14.452516708037157 19.230835815591192 -6.9277401376752685 0.7651237659470023 0.7993538873102309 16.803914877635865 0.9960749530349153 0.3792025747757118 0.09382854757188763 0.08355688091960947 0.34093528465219586 1.1109147615083883 1.1810270978781634e-07 6.9277401376752685 16.004560990325633 NQEACK(ub)AVMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 NQEACKAVMR 10 1 P59045;K7EQV0;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 25826670.0 7419160.0 14562800.0 3844710.0 True False 9726590.607247632 12390087.005349802 3446896.290262495 1.0 1.2738365893715629 0.3543786748559242 23.21350276528878 -6.826884234920787 1.3416723254358849 1.146665872413529 0.331156730974352 0.8995213301017867 0.12218460889581259 0.18468455585275 0.6512516382606972 0.07152394624196905 0.16464184744973365 1.489758133146521e-07 6.826884234920787 -0.8155091414391771 down NQEACK(ub)AVMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQEACKAVMR 10 1 P59045;K7EQV0;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 29366000.0 7246700.0 6899300.0 15220000.0 True False 10993773.70473453 5668066.010523063 12211760.328837017 1.0 0.5155705550026083 1.1107887661520588 23.39018335264588 -6.690241693127101 1.8652391311353274 0.6963711092714648 1.1087566955255346 0.371724385955684 0.20486814805312065 0.41613610672238743 2.807112154724873 0.08785398439651779 0.22873501523478276 2.040601994845713e-07 6.690241693127101 0.41238558625406974 NQEACK(ub)AVMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NQEACKAVMR 10 1 P59045;K7EQV0;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 9011440.0 7419160.0 839120.0 753160.0 True False 10162223.947260208 802044.903801233 575279.1198171002 1.0 0.07892415163882201 0.056609569204799766 23.27671282681167 NQEACK(ub)AVMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NQEACKAVMR 10 1 P59045;K7EQV0;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 25836300.0 8909400.0 4966680.0 11960220.0 True False 11533393.930529684 4690279.891937397 9783582.6822205 1.0 0.4066695302517939 0.8482830588420887 23.459313781385184 -9.82165315821213 6.260632873996231 1.000000015629927 0.6274762945468016 0.4868563190014743 0.18028796809330103 3.919671257289924e-08 7.478711627583846e-09 0.17456307968884413 0.05818769149548936 1.507810772497269e-10 9.82165315821213 -0.37252372108312526 NQEQEK(ub)VER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQEQEKVER 9 1 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 6715100.0 1932500.0 1543300.0 3239300.0 True False 2646997.4738488416 1475111.9029893721 2474244.055477635 1.0 0.5572774124504545 0.9347360849120812 21.33592538732806 -10.111478443071116 7.45023223534054 1.0000000609719708 0.7460067486812679 0.37645446272492855 0.1540968577532183 1.5589468744979544e-07 1.880054682990576e-08 0.1492036765180385 0.04973454698175896 7.736090771950818e-11 10.111478443071116 -0.2539933122907029 NQEQMK(ub)PLEEK ddPTM_RPMI8226_Bortezomib_1h_R1 2 NQEQMKPLEEK 11 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 8744160.0 3570650.0 3089570.0 2083940.0 True False 4681156.728223788 2628618.199049538 1868313.8793640176 1.0 0.5615317648308985 0.39911372078177104 22.15843363756695 -13.999999999999998 0.13796134424032253 3.091024422731537 0.19308911522300282 0.9996111852753767 0.0050043863930793585 11.932471676096046 0.11621950120232227 6.725183477995214 0.18394257919724197 1.0000000000000041e-14 13.999999999999998 -2.897935307508534 NQEQMK(ub)PLEEK ddPTM_RPMI8226_Bortezomib_2h_R1 2 NQEQMKPLEEK 11 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 9397270.0 3559800.0 3371520.0 2465950.0 True False 3446796.097536006 4717785.518244535 1820043.7180857277 1.0 1.3687451722534776 0.5280392766450018 21.716824524897778 -6.787489427561869 1.50644759972123 1.2067638356674673 0.5197169984976076 0.7930709023905498 0.1565191727673149 0.23910673752649922 1.0720212100917994 0.08179532172862641 0.19185087518473598 1.631212618884062e-07 6.787489427561869 -0.6870468371698597 NQEQMK(ub)PLEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQEQMKPLEEK 11 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 11245300.0 4643400.0 3647600.0 2954300.0 True False 7044377.278011262 2996657.2811711207 2370381.31008431 1.0 0.42539704545993934 0.3364926687676651 22.748040747451284 -13.999999999999998 0.26270211143386923 5.2662953727636355 0.3048299645733184 0.9995678957610277 0.006112943502736435 14.538249465066384 0.16220394260464124 32.98029308254312 0.03832229447699242 1.0000000000000041e-14 13.999999999999998 -4.961465408190317 NQEQMK(ub)PLEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NQEQMKPLEEK 11 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 8492760.0 3570650.0 2738180.0 2183930.0 True False 4890815.79818803 2617198.153649606 1668130.713450211 1.0 0.5351250714899621 0.34107412388506375 22.221643699089842 -13.999999999999998 0.11977895351649677 3.2160299386550975 0.03043277535760723 0.9996940275985121 0.004836122578238026 11.964626806658117 0.10648437466702178 6.313273472095771 0.2756557069931796 1.0000000000000041e-14 13.999999999999998 -3.18559716329749 NQEQMK(ub)PLEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NQEQMKPLEEK 11 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 9985610.0 3559800.0 5260500.0 1165310.0 True False 2960131.425879112 5232160.642372508 1408970.933215328 1.0 1.7675433585921405 0.47598255972600473 21.497229800332054 -6.74570055275761 1.6657070118522839 1.4536336017540195 0.4742227947477219 0.6303313640385941 0.3224806968179706 0.3075820787771593 1.6776686364547555 0.15302563659108512 0.3732046304737915 1.795971527334211e-07 6.74570055275761 -0.9794108070062976 NQEQMK(ub)PLEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NQEQMKPLEEK 11 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 15282900.0 6348800.0 4968800.0 3965300.0 True False 8218646.75355768 4692281.91207377 3243656.0874138563 1.0 0.570931207140954 0.3946703374262613 22.970469434927846 -13.999999999999998 0.12226423767452482 3.042078180302808 0.12174225284482268 0.9996819077477828 0.0045338184169572806 11.955635911890246 0.10789758120628047 5.915156976017009 0.24224763431745622 1.0000000000000041e-14 13.999999999999998 -2.920335927457985 NQEQMKPLEEK(ub)QEEER ddPTM_RPMI8226_Bortezomib_1h_R1 2 NQEQMKPLEEKQEEER 16 2 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 59999300.0 25931900.0 23375800.0 10691600.0 True False 33996972.02487681 19888221.75815473 9585335.793069052 1.0 0.5849997977349807 0.2819467506122344 25.018902921185443 -8.016402879701566 0.24351823016650462 1.1869744809896117 4.5848738075556006e-11 0.9996413463061858 0.005574047730577978 0.09949784865858081 0.044874461222308794 0.07066314043596486 0.09743849162879269 9.629353279593557e-09 8.016402879701566 -1.186974480943763 down NQEQMKPLEEK(ub)QEEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQEQMKPLEEKQEEER 16 2 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 37397500.0 1886500.0 20295600.0 15215400.0 True False 1826614.0901178939 28399738.9201558 11230030.287784254 1.0 15.547749836049286 6.148003756534826 20.800740436414102 -9.833949628512315 13.174009889856839 1.0000021179123444 10.847876796292056 0.5940729059160639 3.8374302677563716 0.0 0.0 3.7155762120107836 1.2385252932710284 1.4657178318477224e-10 9.833949628512315 9.84787467837971 NQEQMKPLEEK(ub)QEEER ddPTM_RPMI8226_Bortezomib_8h_R1 2 NQEQMKPLEEKQEEER 16 2 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 137433000.0 63917200.0 48273200.0 25242600.0 True False 96967065.37323996 39658470.29976694 20253389.045775365 1.0 0.4089890742502712 0.2088687428851972 26.530991486862852 -13.981985595684073 0.15328870830987926 3.8638567204052134 1.6458890861759224e-19 0.999555939738913 0.007077533484284722 11.917008208213128 0.12354801015824847 10.161406149495606 0.19005497686124503 1.0423520006788297e-14 13.981985595684073 -3.8638567204052134 NQEQMKPLEEK(ub)QEEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQEQMKPLEEKQEEER 16 2 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 48746500.0 22238000.0 15147900.0 11360600.0 True False 30459989.559353456 14478615.690593354 8677460.258901367 1.0 0.4753322604520511 0.28488060516214947 24.860412111530124 -13.999999999999998 0.14097362605773406 3.508487653692739 0.0519286219194883 0.9995990806726027 0.006054693151584837 11.935127321641668 0.11770683296819127 8.231468346011312 0.20839552587823226 1.0000000000000041e-14 13.999999999999998 -3.456559031773251 NQEQMKPLEEK(ub)QEEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQEQMKPLEEKQEEER 16 2 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 37329300.0 1886500.0 29549100.0 5893700.0 True False 1568708.336120273 29389913.133262876 7126045.420610116 1.0 18.73510356039158 4.542619718738947 20.58114571184838 -9.718838039652702 10.325910056637639 1.0000007149216565 11.638860087237273 0.4283182445143786 5.79405726579084 0.0 0.0 5.610071824345182 1.8700239414483935 1.9105656281545334e-10 9.718838039652702 10.638859372315617 NQEQMKPLEEK(ub)QEEER ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NQEQMKPLEEKQEEER 16 2 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 131558200.0 63917200.0 42269100.0 25371900.0 True False 82742075.39637372 39916787.42747486 20754474.53767827 1.0 0.4824242954537283 0.2508333811818777 26.302117808955302 -10.512579087253476 0.17292220231837918 1.8229077809769474 1.0348948630532205e-09 0.9995555887979735 0.006602292465393651 2.2912462525076402 0.08960060562490305 0.9736152145634772 0.17152481343077253 3.0719978877496567e-11 10.512579087253476 -1.8229077799420526 NQESSFEAVK(ub)DPCFSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQESSFEAVKDPCFSAK 17 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 19337100.0 4379100.0 7357600.0 7600400.0 True False 5741042.50726472 6259874.759700175 6813983.516184865 1.0 1.090372480569326 1.186889577557115 22.452881306834243 -6.97028930711289 0.25118106830114234 0.9698116007253343 1.3102815657980096 0.9999845460892568 0.0002999345136897073 0.07620893345583571 0.008693661664073227 0.0021355758659204554 0.009232499949313532 1.0708057458000659e-07 6.97028930711289 0.34046996507267524 NQESSFEAVK(ub)DPCFSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQESSFEAVKDPCFSAK 17 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 14773800.0 6628700.0 4273000.0 3872100.0 True False 6418275.546866937 5979231.183400629 2857880.849489951 1.0 0.9315946533830842 0.44527238330941055 22.61375429748628 -6.932360070372036 0.7271577334086411 1.0067865106103562 0.33915472562737115 0.9969821156268915 0.013566915428773125 0.09143075349941208 0.0718113626634076 0.012538404456431403 0.043446813815137666 1.1685301694886983e-07 6.932360070372036 -0.667631784982985 down NQESSFEAVK(ub)DPCFSAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQESSFEAVKDPCFSAK 17 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 32878600.0 7668600.0 10946000.0 14264000.0 True False 11633826.849756043 8992600.778511658 11444714.147866715 1.0 0.7729701408354921 0.983744583417683 23.471822401523625 -10.46900611104386 7.733891163545589 1.0000095156154485 0.8783573621598758 0.3075241009306512 0.08604830585765309 1.4119340792207676e-05 9.693376806828558e-07 0.08332242923578596 0.027771971296337693 3.396204936894061e-11 10.46900611104386 -0.12165215345557268 NQESSFEAVK(ub)DPCFSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQESSFEAVKDPCFSAK 17 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 16496200.0 4379100.0 6610900.0 5506200.0 True False 5998171.610727791 6318808.5786771495 4205748.96374863 1.0 1.0534557843219918 0.7011718298000353 22.516091368357134 -6.868219518148403 1.1434101093886608 1.029933060522904 0.6812211711655058 0.9628769616023501 0.029866778008535634 0.13857683882235858 0.339714182051023 0.02029219070722444 0.04790180966020435 1.3545045924617703e-07 6.868219518148403 -0.34871188935739816 NQESSFEAVK(ub)DPCFSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQESSFEAVKDPCFSAK 17 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 15249900.0 6628700.0 2941000.0 5680200.0 True False 5512057.7512008725 2925156.249257204 6867903.557722582 1.0 0.5306831643082697 1.2459781569281128 22.394159572920557 -6.729683792676879 1.724146193982461 0.7174714597798584 1.2455466858478337 0.5578968325253626 0.1972948103242755 0.33683488839787584 1.9614552889537373 0.09068239994352743 0.22512317748866792 1.8634434053203464e-07 6.729683792676879 0.5280752260679753 NQESSFEAVK(ub)DPCFSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NQESSFEAVKDPCFSAK 17 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 26000500.0 7668600.0 10298000.0 8033900.0 True False 9927153.87070508 9724907.24733046 6571812.634775219 1.0 0.9796269277167703 0.6620037042206594 23.242948723616074 -6.919962249534503 0.8250207869057352 1.0070177593907572 0.6108309411385621 0.9941701112527478 0.011816091481639559 0.09819397989639954 0.10573410427343863 0.010178716752018098 0.030478448232454082 1.2023689443834032e-07 6.919962249534503 -0.39618681825219515 NQESSFEAVKDPCFSAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQESSFEAVKDPCFSAKR 18 2 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 6733200.0 1904100.0 1428600.0 3400500.0 True False 2608097.2263677013 1365479.728251551 2597371.9354958427 1.0 0.5235539973152211 0.9958876951505387 21.314566221632425 -10.940328747472066 10.24812830573555 1.0587756501327623 0.7597208462328807 0.25652927542394854 0.1928294246697432 0.11047222642060803 0.0006432402659060818 0.07965167468748217 0.06223542920038944 1.1472848336296448e-11 10.940328747472066 -0.2990548038998816 NQFETEINITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQFETEINITK 11 0 P15924 P15924 DSP Desmoplakin 0 2714300.0 2714300.0 0.0 0.0 False True 3558473.5853185905 0.0 0.0 1.0 0.0 0.0 21.76282709615284 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 NQFETEINITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQFETEINITK 11 0 P15924 P15924 DSP Desmoplakin 0 2291600.0 1361300.0 0.0 930300.0 False True 1131981.2658152797 0.0 1124821.4287787983 1.0 0.0 0.9936749509442414 20.11041865122273 -11.996514382879877 14.213355061186475 0.8704045715418683 0.5471537279249237 0.0 0.4843649281003944 0.0 0.0 0.0 0.13865624834796797 1.0080582241359838e-12 11.996514382879877 -0.32325084361694467 NQFETEINITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NQFETEINITK 11 0 P15924 P15924 DSP Desmoplakin 0 11717000.0 2946700.0 6219100.0 2551200.0 False True 3814561.2381408135 5873001.6179717295 2086907.777522566 1.0 1.53962703737696 0.5470898609926913 21.86308569297331 -6.759065671813857 1.6160491037018305 1.3138092095962075 0.5436376045704919 0.687125238267554 0.22693853149040066 0.28448626386642506 1.4641167647188755 0.11081165287491467 0.26653754954978365 1.7415435060834688e-07 6.759065671813857 -0.7701716050257156 NQGGGLSSSGAGEGQGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQGGGLSSSGAGEGQGPK 18 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 10701200.0 3291900.0 1053900.0 6355400.0 False True 3187400.436394954 1474727.7660158945 4690730.082086834 1.0 0.4626741432224487 1.4716475622348195 21.603948847087782 -6.762040299406813 1.604907948410209 0.688684078672167 1.4756956935454821 0.6992081676580686 0.2260703494224422 0.2794971951194026 1.419332123558819 0.11112005765518758 0.2664912160259979 1.7296558521355592e-07 6.762040299406813 0.7870116148733152 NQGGYGGSSSSSSYGSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQGGYGGSSSSSSYGSGR 18 0 P09651;F8W6I7;P09651-3;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 120753630.0 7534300.0 55560000.0 57659330.0 False True 9877540.262264986 47270664.571183704 51693295.63894835 1.0 4.785671666839071 5.233417861775917 23.23572039117016 -9.840790086419284 0.5357623220814524 3.147835821070547e-21 5.207964742400872 0.9991452439420782 0.05551768724123779 1.1192740176085765 0.24426775781404955 2.0610921431180693 0.08505204370727883 1.4428125576384202e-10 9.840790086419284 5.207964742400872 NQGGYGGSSSSSSYGSGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQGGYGGSSSSSSYGSGR 18 0 P09651;F8W6I7;P09651-3;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 129905000.0 37575000.0 15770000.0 76560000.0 False True 36382202.19251517 22067043.23946358 56506639.24923186 1.0 0.606534016899158 1.5531396079387643 25.116729535295082 -6.7938107521974915 1.4810540723909011 0.7811779006781937 1.5642943457639142 0.8134467541892972 0.16770446950121853 0.22971334852518985 0.995297626596721 0.08910913315133481 0.2080640130061132 1.6076416449878518e-07 6.7938107521974915 0.7831164450857205 NQGGYGGSSSSSSYGSGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQGGYGGSSSSSSYGSGR 18 0 P09651;F8W6I7;P09651-3;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 408562600.0 11269000.0 389070000.0 8223600.0 False True 17095896.874253567 319637418.6822155 6598201.855468077 1.0 18.69673296658625 0.3859523664654864 24.027146774733474 -6.517504926207075 2.5306603309528426 9.999999999999998 0.37758072021566347 0.27474350034684225 7.23089511559247 0.5645362533492184 6.755720903166245 2.8066025910908907 9.259016336868912 3.037351639037725e-07 6.517504926207075 -9.622419279784335 NQGGYGGSSSSSSYGSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQGGYGGSSSSSSYGSGR 18 0 P09651;F8W6I7;P09651-3;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 126255300.0 7534300.0 68887000.0 49834000.0 False True 10319934.31680172 65843344.56115401 38064235.56344656 1.0 6.380209654431184 3.6884183944344286 23.298930452693053 -9.835560186796485 8.06377172176665 0.9999999983649195 5.034314024432807 0.7496864834075415 1.0989191801792455 3.224054681803106e-08 7.864901112821258e-09 1.0640239209155293 0.3546746403051767 1.4602923604792983e-10 9.835560186796485 4.034314026067888 NQGGYGGSSSSSSYGSGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQGGYGGSSSSSSYGSGR 18 0 P09651;F8W6I7;P09651-3;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 46889800.0 37575000.0 6235800.0 3079000.0 False True 31245277.354741193 6202206.507690616 3722804.664312493 1.0 0.1985006065804529 0.11914775542063129 24.89713481072936 -13.999999999999998 0.326930359699902 9.565310437990908 0.1045842898640768 0.9997084351525989 0.006793482500774989 18.56733723548283 0.18267995310028465 109.17784627343052 0.02572410648058793 1.0000000000000041e-14 13.999999999999998 -9.460726148126831 NQGGYGGSSSSSSYGSGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NQGGYGGSSSSSSYGSGR 18 0 P09651;F8W6I7;P09651-3;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 34057000.0 11269000.0 11589000.0 11199000.0 False True 14587942.645199329 10944061.962450271 9160896.911443727 1.0 0.7502128455414374 0.6279773052479364 23.798273096825923 -13.999999999999908 0.09376776790218666 2.259608581931668 0.34051452551359485 0.9998244547370032 0.0020513177092676242 12.130750575829447 0.08987249925200695 3.008788610949134 0.2574606647312957 1.0000000000002127e-14 13.999999999999908 -1.919094056418073 NQGNLYDK(ub)AGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQGNLYDKAGK 11 1 Q8TCJ2 Q8TCJ2 STT3B Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B 1 13862170.0 1414300.0 2528270.0 9919600.0 True False 1854160.996100681 2151061.9711192735 8893214.947522145 1.0 1.1601268582625663 4.796355314465499 20.82233508739327 -6.9161271077065765 0.8529591767944715 0.9080351414895962 5.3334948987277535 0.9930357019935953 0.1463000190867882 0.1005043466619147 0.11781939107195803 0.12353248289450956 0.3573803081576771 1.2130337722572065e-07 6.9161271077065765 4.4254597572381575 up NQGNLYDK(ub)AGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQGNLYDKAGK 11 1 Q8TCJ2 Q8TCJ2 STT3B Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B 1 24859860.0 1592400.0 3791560.0 19475900.0 True False 1541850.133635691 5305549.6807242 14374577.525523974 1.0 3.441028129117637 9.322940804647883 20.55623111280798 -6.956246413917915 0.4854574925728096 0.8658187954626417 12.145654830764416 0.9996046395366512 0.06945917861025332 0.08107033537475915 0.02630121615776224 0.08387298988827042 0.4851398612485223 1.1059960758940732e-07 6.956246413917915 11.279836035301773 NQGNLYDK(ub)AGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQGNLYDKAGK 11 1 Q8TCJ2 Q8TCJ2 STT3B Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B 1 19903700.0 1414300.0 2257600.0 16231800.0 True False 1937204.930020395 2157851.7671151496 12398183.144414483 1.0 1.1138995847447237 6.400036956484493 20.88554514891616 -6.9115516520563895 0.885107948442509 0.8442535641627479 7.106335222154728 0.9914939329890188 0.23234022027674298 0.103400705111538 0.13326997282831857 0.19169166289115616 0.5350167633452698 1.2258810959783952e-07 6.9115516520563895 6.26208165799198 up NQGNLYDK(ub)AGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQGNLYDKAGK 11 1 Q8TCJ2 Q8TCJ2 STT3B Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B 1 23986180.0 1592400.0 5326180.0 17067600.0 True False 1324151.155281166 5297486.811176039 20636356.248333845 1.0 4.000666230624696 15.584592564095892 20.336636388242255 -6.945691195872439 0.604302748738218 0.8706596903671733 19.311980185347327 0.9988182721934817 0.21617352085587482 0.08526352098832453 0.04348878063957002 0.22093723967215956 0.9748720352947787 1.1332058403332009e-07 6.945691195872439 18.441320494980154 NQGSELSGVISSACDK(ub)ESNMER ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQGSELSGVISSACDKESNMER 22 1 O43683-2;O43683-3;O43683;A0A590UK50 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 20661800.0 5421600.0 12217000.0 3023200.0 True False 7107770.102849077 10394271.221493011 2710388.264582139 1.0 1.4623814601609826 0.38132750853825553 22.760965588219836 -6.790468839498671 1.494312240017682 1.2582703225931144 0.36965666955207993 0.8028808188761388 0.19662730528368527 0.2346540548991924 1.035097895462663 0.10356564178749927 0.24240533975675216 1.6200602285785372e-07 6.790468839498671 -0.8886136530410345 down NQGSELSGVISSACDK(ub)ESNMER ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQGSELSGVISSACDKESNMER 22 1 O43683-2;O43683-3;O43683;A0A590UK50 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 51877000.0 17024000.0 12811000.0 22042000.0 True False 25826652.62111035 10524776.957200134 17685389.038648196 1.0 0.40751610793716747 0.6847727925914953 24.622357332837073 -10.451713511416607 6.1642042407713005 1.000189307470383 0.5461444502643499 0.7813161084686426 0.11318956752980781 0.000294598795852489 2.620333886904293e-05 0.10964024500412307 0.0365317758339471 3.534162289970356e-11 10.451713511416607 -0.45404485720603305 NQGSELSGVISSACDK(ub)ESNMER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQGSELSGVISSACDKESNMER 22 1 O43683-2;O43683-3;O43683;A0A590UK50 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 18056400.0 5421600.0 9858100.0 2776700.0 True False 7426112.033230977 9422536.545622723 2120900.6479315734 1.0 1.268838458598252 0.2856004108799857 22.824175649742728 -6.8338474039722845 1.3107241981450517 1.1433092733102703 0.25701884573329176 0.913334602410341 0.12214708298448805 0.17611247781668107 0.5903697404154519 0.07314026735519782 0.1683173838057109 1.4660628741464898e-07 6.8338474039722845 -0.8862904275769785 down NQGSELSGVISSACDK(ub)ESNMER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQGSELSGVISSACDKESNMER 22 1 O43683-2;O43683-3;O43683;A0A590UK50 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 14246500.0 7548500.0 2906500.0 3791500.0 True False 6276912.20524986 2890842.1076049204 4584285.120084712 1.0 0.4605516236449968 0.7303408061451816 22.581623599507484 -10.466628225184412 7.389110574431237 1.000046326675666 0.5954462148950962 0.749879506876353 0.1101409725413436 8.406698682709193e-05 6.068268233949634e-06 0.10665568393502699 0.035547846032309344 3.414851125266266e-11 10.466628225184412 -0.40460011178056987 NQGSELSGVISSACDK(ub)ESNMER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NQGSELSGVISSACDKESNMER 22 1 O43683-2;O43683-3;O43683;A0A590UK50 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 68061000.0 17024000.0 15451000.0 35586000.0 True False 22037903.593209088 14591138.267479409 29109713.143194582 1.0 0.6620928440750428 1.3208930250590918 24.393483654929522 -6.76728624046825 1.5846784375979261 0.8055064795697154 1.3242350210888227 0.7200609412164776 0.14231743426478327 0.2708788962101343 1.3420103414973794 0.07080385429723865 0.16897681330169328 1.7088886272428617e-07 6.76728624046825 0.5187285415191073 NQHFEVPFIAFYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQHFEVPFIAFYR 13 0 Q7KZ85;Q7KZ85-3 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 13094000.0 3102800.0 6713400.0 3277800.0 False True 4249989.010017167 6416779.789754976 2503651.1484100255 1.0 1.50983444301402 0.5890959111915239 22.01902767993587 -6.75642069287775 1.6260779465596495 1.29746394131345 0.5863335491421467 0.6760905169625642 0.21434164590691163 0.28899529220793335 1.505206134588918 0.10404820494201525 0.25092255779351824 1.7521823734672228e-07 6.75642069287775 -0.7111303921713034 NQHFEVPFIAFYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQHFEVPFIAFYR 13 0 Q7KZ85;Q7KZ85-3 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 11912840.0 6471900.0 3762840.0 1678100.0 False True 5381671.603783081 3742568.834054737 2028982.951342253 1.0 0.6954286901162593 0.3770172356700409 22.359622927963507 -7.081059926001971 0.2574095009578266 1.0979210580373528 6.188935203762159e-15 0.9999807399343433 0.0011162441611004663 0.07463688608295334 0.009676809035520097 0.00771843620650034 0.03052451759813786 8.297362686893295e-08 7.081059926001971 -1.0979210580373466 down NQIHVK(ub)SPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQIHVKSPPR 10 1 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07 Q13098-7 GPS1 COP9 signalosome complex subunit 1 1 10052000.0 3976700.0 3206300.0 2869000.0 True False 3850461.8352355305 4486592.310633616 2117522.831844909 1.0 1.1652088769136373 0.5499399610892083 21.876600066415925 -6.835225106294755 1.3043098769171912 1.0880108467724072 0.5315331188816091 0.9159455082520771 0.07537983531521965 0.17444644747224775 0.578520095166961 0.04534894585070465 0.10438340266067833 1.461419485809684e-07 6.835225106294755 -0.5564777278907981 NQIHVK(ub)SPPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQIHVKSPPR 10 1 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07 Q13098-7 GPS1 COP9 signalosome complex subunit 1 1 9657300.0 3885900.0 2166600.0 3604800.0 True False 5895194.39734333 1779953.3022769366 2892309.699960034 1.0 0.3019329274500384 0.4906215987149556 22.491107956992153 -10.915307721537514 11.49876790578494 1.0641181050134507 0.39627726308250555 0.931739075887363 0.07703182747380027 0.0360983069537763 0.00026587564164216735 0.0212636785459048 0.024861915411162616 1.215324571165319e-11 10.915307721537514 -0.6678408419309452 NQIHVK(ub)SPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQIHVKSPPR 10 1 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07 Q13098-7 GPS1 COP9 signalosome complex subunit 1 1 7664000.0 2490300.0 2975600.0 2198100.0 True False 3411031.20782705 2844128.153006662 1678954.0512905226 1.0 0.8338030289727177 0.49221304321049497 21.701776523680756 -6.959507716846074 0.44231957638698655 1.0119225876717135 0.3007240219791182 0.9997514958143863 0.0033322721722964057 0.07987747800766902 0.02178486596308772 0.004516969266128792 0.028290738893998777 1.0977217850171198e-07 6.959507716846074 -0.7111985656925953 down NQIHVK(ub)SPPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NQIHVKSPPR 10 1 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07 Q13098-7 GPS1 COP9 signalosome complex subunit 1 1 7660200.0 3885900.0 1878300.0 1896000.0 True False 5030374.152540608 1773770.9538416013 1550947.4546028492 1.0 0.35261213183233137 0.30831652031679146 22.262234279084602 -13.914531295504759 0.38153136275913785 9.99999993118426 0.3044935812685677 0.9998082144615029 0.004378110150637146 22.629937002633838 0.20136477123855262 166.94561092728958 0.011956276425279955 1.2174992560025938e-14 13.914531295504759 -9.695506349915691 NQK(ub)DPGVLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQKDPGVLDR 10 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 31527700.0 13808000.0 9249300.0 8470400.0 True False 18102421.716862217 7869340.493489016 7593964.2618141435 1.0 0.4347120300572165 0.41949990893983236 24.109679376171915 NQK(ub)DPGVLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQKDPGVLDR 10 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 43222000.0 13928000.0 16906000.0 12388000.0 True False 13485863.263801744 23656653.963625304 9143211.167966098 1.0 1.7541816568112196 0.6779848637875461 23.684944539255092 -6.718320522467576 1.7652116179506123 1.4596527117478295 0.6798025598142603 0.504636281760549 0.31742961858996 0.3585961030127864 2.182767368078323 0.14283002027216643 0.35928689772683303 1.912843667439571e-07 6.718320522467576 -0.7798501519335692 NQK(ub)DPGVLDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQKDPGVLDR 10 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 69081000.0 21207000.0 20392000.0 27482000.0 True False 32172569.43937312 16752888.276576784 22050170.654211495 1.0 0.5207196244660033 0.6853717635379868 24.939327824616623 -10.146091866740074 5.577799362915598 1.0000068519198735 0.603045694001946 0.8857103958635183 0.06721895429752894 5.727625738037819e-06 8.768767720145131e-07 0.0650855952008071 0.021694824211958726 7.143452039470668e-11 10.146091866740074 -0.3969611579179275 NQK(ub)DPGVLDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NQKDPGVLDR 10 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 69626000.0 21207000.0 17493000.0 30926000.0 True False 27452879.552466273 16519499.172417158 25297785.327556796 1.0 0.6017401249601557 0.9214984271216142 24.710454146709072 -9.904532511729093 6.476119457011774 1.0000000191819525 0.7616192760408724 0.4256282341899498 0.13054078021908788 3.622538606197396e-08 5.961987146574319e-09 0.12639557730625653 0.04213185564911419 1.2458549678025715e-10 9.904532511729093 -0.23838074314108004 NQK(ub)FGFGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQKFGFGGK 9 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 3113310.0 749500.0 412610.0 1951200.0 True False 982601.7581683246 351050.1963411826 1749308.5412320264 1.0 0.35726599654734786 1.7802823236271486 19.90624729494082 -6.783899237053968 1.5204683273420376 0.6379016306564078 1.7930056022956868 0.7809899950528804 0.2722961244868242 0.2445740446524641 1.116957261885604 0.14101205091357086 0.33169101892413777 1.6447532868062268e-07 6.783899237053968 1.155103971639279 NQK(ub)FGFGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQKFGFGGK 9 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 8994790.0 1540370.0 1443920.0 6010500.0 True False 1491471.7975059082 2020484.7859433289 4436169.738865052 1.0 1.3546919152759407 2.974357105701477 20.50830526708912 -6.941847174434559 0.6421480379234519 0.9822403958248179 3.4359356315663607 0.9983959858086966 0.034419334242312104 0.08693393531647463 0.050847133350610724 0.03399365135588734 0.1383064744657776 1.1432805774377923e-07 6.941847174434559 2.453695235741543 up NQK(ub)FGFGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQKFGFGGK 9 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 7240170.0 1540370.0 2672390.0 3027410.0 True False 1280885.9049613469 2657993.30464212 3660427.433837706 1.0 2.0751210504750848 2.8577310591517255 20.288710542523397 -7.727403261533324 0.16049649653317213 1.4358474042297597e-18 4.358279006352164 0.9999613402214353 0.004735040908715403 0.13619934936965275 0.020723586627753966 0.2020405657305673 0.3043780944400211 1.8732543012302402e-08 7.727403261533324 4.358279006352164 NQLLLEFSFWNEPQPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQLLLEFSFWNEPQPR 16 0 Q9BPW8;C9JDV8;H7C2U6 Q9BPW8 NIPSNAP1 Protein NipSnap homolog 1 0 19131500.0 5726800.0 4350100.0 9054600.0 False True 8687974.285160655 3573790.6675135726 7264954.341227835 1.0 0.41134913044318333 0.8362080851961792 23.05058840235525 -10.310499093727083 5.944965991156254 1.000029949017926 0.6237786078197095 0.5111289476908982 0.1734479419661771 6.885550108986703e-05 7.985968195388504e-06 0.1679535869105981 0.05598008255574577 4.8921628601547074e-11 10.310499093727083 -0.37625134119821657 NQLLPELQVIHNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQLLPELQVIHNR 13 0 F8WDV0;Q9UI26;Q9UI26-2 F8WDV0 IPO11 Importin-11 0 4223560.0 1419700.0 380560.0 2423300.0 False True 1374632.400604489 532519.5925941827 1788565.032558302 1.0 0.38739054336272694 1.3011224177254863 20.390614439067924 -6.726014376771454 1.737459290067696 0.629717895193728 1.3002273977229484 0.540848207496355 0.2576166939528004 0.343750935783926 2.0309857358876404 0.11758326904862891 0.2931344960588392 1.8792546054183923e-07 6.726014376771454 0.6705095025292204 NQLLPELQVIHNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQLLPELQVIHNR 13 0 F8WDV0;Q9UI26;Q9UI26-2 F8WDV0 IPO11 Importin-11 0 3982180.0 1419700.0 1568400.0 994080.0 False True 1180543.4533739449 1559950.7178969749 1201937.5318933958 1.0 1.3213835657117912 1.0181222287568557 20.1710197145022 -10.375427813583391 3.9191997507467162 0.9993980077343496 1.1697528972027724 0.2946678309530768 0.12380592242463191 0.0006571414986574261 0.00010472332049686915 0.1202984417944858 0.039958189635819416 4.212813043614349e-11 10.375427813583391 0.1703548894684228 NQLLQQVDHLK(ub)QEISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQLLQQVDHLKQEISR 16 1 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 48376300.0 12499200.0 7390100.0 28487000.0 True False 12102419.737716181 10341005.468862386 21025400.108318556 1.0 0.854457678131548 1.7372889524559003 23.528792190603422 -6.864579731682838 1.1624691048191358 0.9198591111243252 1.7839158566687434 0.9589629283946718 0.0782877483380923 0.14215312074358522 0.362469402000211 0.05242266127660931 0.12306474472406496 1.3659042876892722e-07 6.864579731682838 0.8640567455444182 NQLLQQVDHLK(ub)QEISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQLLQQVDHLKQEISR 16 1 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 42481000.0 12499200.0 10843500.0 19138300.0 True False 10393638.608446602 10785083.913233781 23140030.044498824 1.0 1.0376620084201373 2.226364694428918 23.3091974660377 -6.913650094920247 0.8705069770901862 0.9673066939189411 2.392611813750353 0.9922276872331829 0.050202633351843357 0.10205360912758003 0.12603996922222133 0.041858230195423195 0.11869012149786456 1.219972117795586e-07 6.913650094920247 1.4253051198314117 up NQLTAMSSVLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQLTAMSSVLAK 12 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 14120000.0 3170000.0 4998200.0 5951800.0 False True 4155900.698323672 4252488.042831003 5335964.829696997 1.0 1.023241013565673 1.2839490683329648 21.98672975201973 -6.924387726452003 0.791483863274755 0.9951055725528974 1.3305512300844626 0.9953159864749218 0.00881005934692789 0.0956579606613706 0.09273005961753997 0.0077729164135900836 0.024357814835091418 1.1901789737440328e-07 6.924387726452003 0.3354456575315652 NQLTAMSSVLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQLTAMSSVLAK 12 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 10528400.0 3170000.0 3740400.0 3618000.0 False True 4342034.666028894 3575136.7601512633 2763502.9150489564 1.0 0.8233782166969629 0.6364534435134717 22.049939813542622 -6.970407346151276 0.24826524906913633 1.0606015708644443 0.3937673598415247 0.9999853859832802 0.0005674202851533074 0.07617075294023866 0.008555944045392526 0.004218607982583546 0.017966190882555758 1.0705147457751073e-07 6.970407346151276 -0.6668342110229195 NQLTSNPENTVFDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQLTSNPENTVFDAK 15 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 117645000.0 1819000.0 54444000.0 61382000.0 False True 2384726.615221059 46321167.421049796 55030779.45772049 1.0 19.424099653769296 23.076347245203724 21.185392454644447 -9.079512549332366 0.6412447493998266 9.81642489901208e-17 22.671878065457715 0.9970907278923334 0.5211343644594593 0.5407248437789591 0.2828517295420718 2.655180015075407 0.6071107553082624 8.326978640786968e-10 9.079512549332366 22.671878065457715 NQLTSNPENTVFDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQLTSNPENTVFDAK 15 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 88872000.0 27582000.0 13023000.0 48267000.0 False True 26706424.507623482 18223151.81404783 35624424.721038096 1.0 0.6823508631357948 1.333927149659024 24.67068350314195 -6.774109575598108 1.5584680701819733 0.8187688131518192 1.338200166226204 0.7461501381678878 0.13403656251210544 0.25981793850530527 1.2458818665502929 0.06776617244573617 0.1607281452847949 1.6822495639467335e-07 6.774109575598108 0.5194313530743848 NQLTSNPENTVFDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQLTSNPENTVFDAK 15 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 365619600.0 4379500.0 356380000.0 4860100.0 False True 6644021.684336986 292781204.59035105 3899499.104742501 1.0 44.06686469440203 0.5869184795009644 22.663625351208808 -4.5355613638330325 9.11730916019653 9.999999999961043 17.40371831152668 0.0 21.056727933683348 0.0 0.0 7.3267994615072425 0.0 2.9136584190154364e-05 4.5355613638330325 7.403718311565639 NQLTSNPENTVFDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQLTSNPENTVFDAK 15 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 121583000.0 1819000.0 57531000.0 62233000.0 False True 2491533.456626673 54989090.19042413 47534847.12886718 1.0 22.070380008011103 19.078550602015742 21.248602516167338 -9.462879787221459 11.160702227565311 0.9998803645270716 20.57446530501344 0.9827808469454831 1.2214092423101444 0.0 0.0 1.1826244127102823 0.394208137570094 3.444452600694401e-10 9.462879787221459 19.574584940486368 NQLTSNPENTVFDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQLTSNPENTVFDAK 15 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 31383800.0 27582000.0 2422000.0 1379800.0 False True 22935655.08977966 2408952.2052706415 1668309.8005256194 1.0 0.10503088731675655 0.0727387028622101 24.451088778576228 -13.035516832966435 0.48519049920715024 9.999999997278287 0.07392948417241738 0.9999172059356628 0.003909945008098243 16.559931200995422 0.242841569545423 156.35215445707755 0.006768099832546284 9.214741723142702e-14 13.035516832966435 -9.92607051310587 NQLTSNPENTVFDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NQLTSNPENTVFDAK 15 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 16244000.0 4379500.0 6173200.0 5691300.0 False True 5669349.0828512255 5829655.993321074 4655541.79766941 1.0 1.0282760698145663 0.8211774808066762 22.434751673301257 -6.872422653253456 1.1212579792609523 1.0162504219967265 0.8084800614602322 0.9670390158836093 0.01664683392582355 0.13455022765805927 0.3146920695564 0.011504736518484536 0.027357292143197792 1.3414588245488013e-07 6.872422653253456 -0.20777036053649434 NQLTSNPENTVFDAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQLTSNPENTVFDAKR 16 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 7166300.0 1566100.0 1821000.0 3779200.0 True False 2053172.2661339724 1549313.8982024058 3388164.636646202 1.0 0.7545951812020584 1.6502096256277403 20.969423247462785 -6.8336634694000615 1.3114153144124665 0.8691679935768736 1.676173199581293 0.9130179890986478 0.11144626806614193 0.17632869409589136 0.5917661375301181 0.06669687042236191 0.15349888574961432 1.4666839199361816e-07 6.8336634694000615 0.8070052060044194 NQLTSNPENTVFDAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQLTSNPENTVFDAKR 16 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 16549700.0 2266400.0 2575300.0 11708000.0 True False 2194454.372564638 3603630.7200120855 8641323.56752883 1.0 1.6421534049944981 3.9378005191467245 21.065430843094727 -6.947457911822499 0.586087928104267 0.9731395274652439 4.721554522591785 0.9989863948563926 0.04014938641825256 0.08452285988084186 0.040312778416677054 0.04179404725615817 0.19209678154698848 1.128605307185573e-07 6.947457911822499 3.7484149951265415 NQLTSNPENTVFDAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQLTSNPENTVFDAKR 16 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 48174300.0 0.0 9561300.0 38613000.0 True False 0.0 7855011.312222129 30981123.625320863 0.0 NQLTSNPENTVFDAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQLTSNPENTVFDAKR 16 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 11195900.0 1566100.0 1624000.0 8005800.0 True False 2145129.492261148 1552246.31015016 6114994.924626563 1.0 0.7236142693250471 2.8506413932992176 21.032633308985677 -6.874219247752097 1.1114708393077184 0.8388737962718317 2.985657002548582 0.9687187612464397 0.16701556849308777 0.13287690192480106 0.30424383847054504 0.11628821745079189 0.2775343882292924 1.3359209244964478e-07 6.874219247752097 2.1467832062767505 up NQLTSNPENTVFDAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQLTSNPENTVFDAKR 16 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 15125100.0 2266400.0 2675700.0 10183000.0 True False 1884612.018543855 2661285.4730151333 12312218.219127702 1.0 1.4121131812962622 6.53302541742291 20.845836118529004 -6.922895521093192 0.8029483415566403 0.8983639925931906 7.416473952397929 0.994948397989399 0.17887968423736306 0.0964979179712927 0.09700109387724266 0.15653550372549244 0.4827123381813585 1.1942753786147347e-07 6.922895521093192 6.518109959804739 up NQLTSNPENTVFDAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NQLTSNPENTVFDAKR 16 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 51877200.0 0.0 7956200.0 43921000.0 True False 0.0 7513430.475938109 35927828.6675167 0.0 NQMLIEEEVQK(ub)LK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQMLIEEEVQKLK 13 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;H0Y6Y4;H0Y4E0;H0Y636;H0Y4K0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 62196600.0 28299600.0 31399100.0 2497900.0 True False 37101049.6537162 26714476.672733176 2239441.26954873 1.0 0.7200463847269437 0.06036059061537678 25.144956668006113 -7.339631349780343 0.6702212277714165 0.9961094431708476 2.1425280003190565e-16 0.9938787658000384 0.030818808453638824 0.10432411664352828 0.09386204806470978 0.027862528580137606 0.065794443016905 4.574763529617695e-08 7.339631349780343 -0.9961094431708474 down NQMLIEEEVQK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 2 NQMLIEEEVQKLK 13 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;H0Y6Y4;H0Y4E0;H0Y636;H0Y4K0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 89526800.0 12699800.0 20679900.0 56147100.0 True False 12296651.800519045 28937491.914253864 41440490.133105405 1.0 2.35328220914838 3.3700629086168146 23.55176220836504 -7.678938660844551 0.18168552798907853 1.2120406807602638e-13 5.026223624943562 0.9999421899455754 0.007381421952288021 0.13728248442934782 0.02249657402624691 0.20599072863145584 0.3413571501402408 2.0944082463026817e-08 7.678938660844551 5.026223624943441 NQMLIEEEVQK(ub)LK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NQMLIEEEVQKLK 13 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;H0Y6Y4;H0Y4E0;H0Y636;H0Y4K0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 51032800.0 35738000.0 9609200.0 5685600.0 True False 48951304.38313575 9184633.770624952 4342778.378607616 1.0 0.18762796796461173 0.08871629537421989 25.54484396739105 -13.999999999999998 0.2970237596926373 8.284868153732566 0.06362047664719006 0.9996431831409033 0.007712079890573373 16.397102183537097 0.17300015241166783 73.28624911378208 0.03620973366858871 1.0000000000000041e-14 13.999999999999998 -8.221247677085376 NQMLIEEEVQK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NQMLIEEEVQKLK 13 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;H0Y6Y4;H0Y4E0;H0Y636;H0Y4K0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 85674700.0 12699800.0 44981300.0 27993600.0 True False 10560446.396533368 44738976.80881104 33846932.3322177 1.0 4.236466445537502 3.205066439552071 23.332167483799317 -9.860017467036531 8.441240524020168 1.0000006413947256 3.7207664425447855 0.9027073613798708 0.42106728922813363 4.929121770308297e-09 1.4393982134633298e-09 0.4076966436280924 0.135898883234414 1.3803287475781023e-10 9.860017467036531 2.72076580115006 NQMNLLTLDVK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQMNLLTLDVKK 12 1 Q8IWA4;Q8IWA4-3;H7C5H5 Q8IWA4 MFN1 Mitofusin-1 1 11822300.0 2259800.0 3082200.0 6480300.0 True False 2188063.885951983 4312938.53346066 4782915.025167151 1.0 1.9711209353396857 2.1859119634828215 21.061223431129488 -10.685270248590129 0.3041494319214419 7.830386276155143e-14 2.249719880684493 0.9991498187018778 0.015043243309361427 2.3438595997014 0.15048002726094012 1.8121030288177873 0.07577737616074431 2.06409533072214e-11 10.685270248590129 2.249719880684415 NQMTVK(ub)EWEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQMTVKEWEK 10 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 28367900.0 12250000.0 14421500.0 1696400.0 True False 16059868.62916874 12269868.41456672 1520872.8010178392 1.0 0.7640080188627177 0.0947002018594071 23.936956755770254 -7.218571644448059 0.6651673771772473 0.9979355227562986 4.232263189628375e-24 0.9964824493286882 0.0227413926431667 0.09013963368127849 0.07156460654214061 0.02103728979582483 0.05731786395387124 6.045446129421788e-08 7.218571644448059 -0.9979355227562986 down NQMTVK(ub)EWEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQMTVKEWEK 10 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 29058900.0 10699000.0 9497400.0 8862500.0 True False 10359366.101336515 13289761.348286726 6541145.380699032 1.0 1.2828739923162042 0.6314233242374865 23.30443239016671 -6.788711751841698 1.5016981497943103 1.1583637016034303 0.6247594544537438 0.7970558213158041 0.12015541329466894 0.23727742248182215 1.0571334785257005 0.06298730860222225 0.1475942426787254 1.626628016447668e-07 6.788711751841698 -0.5336042471496865 NQMTVK(ub)EWEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQMTVKEWEK 10 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 89466600.0 50160000.0 23124600.0 16182000.0 True False 76096387.18720026 18997834.456675526 12983620.607177444 1.0 0.2496548805916379 0.17062072309999685 26.181324625025287 -13.999999999999998 0.31794967409838365 8.600584443388314 0.15456854731969574 0.9996893165386797 0.006587618848678429 17.855588015584658 0.17973288948136118 90.17617806838098 0.026526102774157612 1.0000000000000041e-14 13.999999999999998 -8.446015896068618 NQMTVK(ub)EWEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQMTVKEWEK 10 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 29953500.0 12250000.0 9868100.0 7835400.0 True False 16779156.043802477 9432094.712557135 5984839.895128408 1.0 0.5621316523867098 0.3566830107250215 24.000166817293145 -12.259896511005575 0.1205299486363585 2.4178802633094314 1.451375439124356e-22 0.999749993622327 0.004242018351105916 6.200514125180047 0.08844582965424803 2.467010895871345 0.2762680259498187 5.496718407737358e-13 12.259896511005575 -2.4178802633094314 NQMTVK(ub)EWEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQMTVKEWEK 10 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 34572600.0 10699000.0 18288700.0 5584900.0 True False 8896692.54606456 18190175.143077265 6752676.768340004 1.0 2.044599726122228 0.7590097930637203 23.084837665600986 -6.690591333349086 1.8641665489502919 1.6545339262666443 0.7634066319608369 0.3732333871731378 0.44173949399663737 0.4154155127486235 2.7993432621535357 0.18952859822448254 0.493205009615186 2.0389598155418322e-07 6.690591333349086 -0.8911272943058074 NQMTVK(ub)EWEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NQMTVKEWEK 10 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 121696000.0 50160000.0 41683000.0 29853000.0 True False 64933108.801419735 39363304.40769816 24420060.317647044 1.0 0.606213149721202 0.37608025810575557 25.952450947117736 -9.181073021166156 0.15106046958586206 1.5306858054803476 2.867833582362216e-11 0.9998205520547843 0.00345100417807473 0.6254897334459675 0.052710717814936386 0.32390776055867504 0.17591823360427208 6.590630727443158e-10 9.181073021166156 -1.5306858054516692 NQNSWGTGEDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQNSWGTGEDVK 12 0 P20700 P20700 LMNB1 Lamin-B1 0 6434070.0 1824100.0 601270.0 4008700.0 False True 1766194.943961857 841360.2465816278 2958701.2115777964 1.0 0.47636884561243426 1.6751838304671838 20.75221315872349 -6.787982148210918 1.50438662980976 0.7065752836819469 1.687235368103925 0.7947278415497109 0.22232857555408858 0.23836835443865698 1.065771267581735 0.11633971501265296 0.2727854056189513 1.629363006658823e-07 6.787982148210918 0.980660084421978 NQNSWGTGEDVK(ub)VILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQNSWGTGEDVKVILK 16 1 P20700 P20700 LMNB1 Lamin-B1 1 8290500.0 1700300.0 2303200.0 4287000.0 True False 1413874.7860616466 2290792.2044505966 5183391.8791515725 1.0 1.6202228280989484 3.666089762863605 20.431222928844374 -6.9493002216625355 0.5664731292369476 0.9740949540583989 4.4110857237458765 0.9991452244594259 0.03330383683737646 0.08376794337628288 0.03713457277219785 0.03542698901333726 0.17031645984650395 1.1238278190266059e-07 6.9493002216625355 3.4369907696874775 NQPLVYLMLTTHPSLYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQPLVYLMLTTHPSLYR 17 0 O95486 O95486 SEC24A Protein transport protein Sec24A 0 7164200.0 4306700.0 1360500.0 1497000.0 False True 4169986.1658683945 1903754.7449137734 1104890.7909626453 1.0 0.4565374246313162 0.2649626993984411 21.991611166791195 -13.999999999999986 0.1453062711229555 3.6107450005943296 0.04237881616333458 0.9995826525320313 0.00636016568775338 11.943165730983857 0.11978949219008693 8.818235697619468 0.1997809266941527 1.0000000000000327e-14 13.999999999999986 -3.568366184430995 NQPLVYLMLTTHPSLYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQPLVYLMLTTHPSLYR 17 0 O95486 O95486 SEC24A Protein transport protein Sec24A 0 62451000.0 19105000.0 23914000.0 19432000.0 False True 28983681.76258891 19646359.85906517 15591256.68265185 1.0 0.6778421050849373 0.5379322340882338 24.788737534580758 -13.999999999999998 0.1135447643223056 2.5458859967021223 0.293890627324615 0.9997251103340576 0.0032076468546166025 11.992976755013174 0.10281357109134315 4.2238425329109885 0.21661021137418943 1.0000000000000041e-14 13.999999999999998 -2.251995369377507 NQPLVYLMLTTHPSLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQPLVYLMLTTHPSLYR 17 0 O95486 O95486 SEC24A Protein transport protein Sec24A 0 8519900.0 4306700.0 1941600.0 2271600.0 False True 3581211.8691593814 1931140.2154225726 2746581.0573083055 1.0 0.5392421018295881 0.7669417944694267 21.77201644222547 -10.14514856428102 5.152792420195651 1.0000136565872848 0.6530919481491484 0.7557920860818308 0.09295801026061329 1.4584419075157399e-05 2.4196740346552113e-06 0.09000974752159675 0.03000206880281448 7.158984724120843e-11 10.14514856428102 -0.3469217084381364 NQPLVYLMLTTHPSLYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NQPLVYLMLTTHPSLYR 17 0 O95486 O95486 SEC24A Protein transport protein Sec24A 0 50601000.0 19105000.0 14853000.0 16643000.0 False True 24731799.115851734 14026417.493163664 13614144.771600842 1.0 0.5671410085234557 0.5504712660744085 24.559863856673207 NQQITHANNTVSNFK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQQITHANNTVSNFKR 16 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;R4GN69 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 5621800.0 1081600.0 1497400.0 3042800.0 True False 1047265.200037907 2095319.6288378413 2245799.397956675 1.0 2.00075360926917 2.1444419215642663 19.998195392998813 -10.823876648838066 0.37020725249065906 1.105317439947107e-11 2.1636215695189187 0.9993575219251326 0.012902175705098974 2.499573391869737 0.18097360332459939 2.2387143579309763 0.03999666048834826 1.5001108463036223e-11 10.823876648838066 2.1636215695078653 NQQITHANNTVSNFK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NQQITHANNTVSNFKR 16 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;R4GN69 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 22293500.0 3520600.0 1803900.0 16969000.0 True False 4557486.101401079 1703511.3792444596 13880816.11664332 1.0 0.3737831210764987 3.04571770660497 22.119806825924226 -6.844958666646031 1.2592751335777774 0.6667802988218147 3.142522275659431 0.9326291953021955 0.296149258908185 0.1630900378320842 0.5002403267047332 0.18424471650574878 0.4251759037065765 1.4290299579143736e-07 6.844958666646031 2.4757419768376163 up NQSQGYNQWQQGQFWGQKPWSQHYHQGYY ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQSQGYNQWQQGQFWGQKPWSQHYHQGYY 29 1 Q00839;Q00839-2;A0A1X7SBS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 21189600.0 11733000.0 6513000.0 2943600.0 False True 15382076.622533632 5541285.7874751575 2639024.5090050222 1.0 0.36024302332219393 0.17156490464616733 23.87474694844706 -13.999999999999998 0.1711605395607159 4.2362315902289875 0.007168939360709009 0.9995115120241033 0.007835630457693426 12.10303115022268 0.13103285990965635 13.00613972498618 0.15221672070074468 1.0000000000000041e-14 13.999999999999998 -4.229062650868278 NQSQGYNQWQQGQFWGQKPWSQHYHQGYY ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQSQGYNQWQQGQFWGQKPWSQHYHQGYY 29 1 Q00839;Q00839-2;A0A1X7SBS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 64696800.0 24538000.0 8840800.0 31318000.0 False True 23759054.62142213 12370977.544162957 23114876.280139018 1.0 0.5206847554030529 0.9728870381609251 24.50197409630474 -10.620790644847968 9.563483790773327 1.0000598308771045 0.746785896781989 0.294816199913124 0.18461080887975773 0.00023556066121145877 9.34045796652228e-06 0.1787905723593902 0.05958288236009849 2.3944697516612486e-11 10.620790644847968 -0.25327393409511545 NQSQGYNQWQQGQFWGQKPWSQHYHQGYY ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQSQGYNQWQQGQFWGQKPWSQHYHQGYY 29 1 Q00839;Q00839-2;A0A1X7SBS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 143576000.0 58616000.0 53764000.0 31196000.0 False True 88924757.40360688 44169394.139950655 25030096.92630749 1.0 0.4967052531779986 0.2814750094026373 26.40608179767532 -11.877511548435434 0.14487686989104667 2.3393290244255915 7.006829166175785e-14 0.9996370034267044 0.005736544097723607 5.119561029580321 0.09718855497415002 2.3137766986995167 0.21668947391467963 1.325831861758319e-12 11.877511548435434 -2.3393290244255214 NQSQGYNQWQQGQFWGQKPWSQHYHQGYY ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQSQGYNQWQQGQFWGQKPWSQHYHQGYY 29 1 Q00839;Q00839-2;A0A1X7SBS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 44966000.0 11733000.0 12796000.0 20437000.0 False True 16071007.172402829 12230630.409286603 15610201.51322704 1.0 0.7610369579256409 0.9713268960537156 23.937957009969953 -10.23947002773298 6.896635136817902 1.0000007610567285 0.8661819270788989 0.3506166001688594 0.08585050774253804 1.0046521587862875e-06 1.1081574694554362e-07 0.08312486984208166 0.02770813222919173 5.761425789161947e-11 10.23947002773298 -0.13381883397782968 NQSQGYNQWQQGQFWGQKPWSQHYHQGYY ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQSQGYNQWQQGQFWGQKPWSQHYHQGYY 29 1 Q00839;Q00839-2;A0A1X7SBS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 58468000.0 24538000.0 18757000.0 15173000.0 False True 20404434.217714936 18655952.318026986 18345604.147974502 1.0 0.9143087291207548 0.8990988895956264 24.282379371739015 -13.999999999999998 0.24317427184816137 1.5760442742552532 0.8925735018300769 0.9995303267054835 0.0009625730535630149 13.737668665932098 0.15606178140579507 3.8499647483691044 0.007295999179576737 1.0000000000000041e-14 13.999999999999998 -0.6834707724251763 NQSQGYNQWQQGQFWGQKPWSQHYHQGYY ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NQSQGYNQWQQGQFWGQKPWSQHYHQGYY 29 1 Q00839;Q00839-2;A0A1X7SBS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 203070000.0 58616000.0 73721000.0 70733000.0 False True 75879567.49409911 69618361.54403277 57860319.781868786 1.0 0.9174849546875283 0.762528328675152 26.17720811976777 -6.961257806537366 0.4173305050468138 1.0070494121503442 0.6671440463261622 0.9998140342678301 0.0013424002115625371 0.07925485182189813 0.019493633373360443 0.002001345446140504 0.012908698130159931 1.0933071629737342e-07 6.961257806537366 -0.33990536582418196 NQTAEK(ub)EEFEHQQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQTAEKEEFEHQQK 14 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 67751000.0 18366000.0 31203000.0 18182000.0 True False 27862564.73445209 25634580.85984828 14588319.730546284 1.0 0.9200366550661108 0.5235813669553475 24.73182472758403 -6.939993703772674 0.6596213947677041 1.00445052106273 0.4166895423151119 0.9981630845673826 0.008928101855477176 0.08776948743806519 0.05462259600336746 0.008690426413046534 0.034123055489281844 1.1481702670885473e-07 6.939993703772674 -0.587760978747618 NQTAEK(ub)EEFEHQQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NQTAEKEEFEHQQK 14 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 63082000.0 18366000.0 31497000.0 13219000.0 True False 23775149.047983896 29744164.2619118 10813277.63839401 1.0 1.2510611059422176 0.4548142943949688 24.50295104967648 -6.821934547488893 1.3634775674626955 1.1350609011575055 0.4366978686717778 0.8887807271095369 0.11084612798836359 0.19097591649444903 0.6970954388765654 0.06387635417427223 0.1471546531887905 1.506834144013109e-07 6.821934547488893 -0.6983630324857277 down NQTAEKEEFEHQQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQTAEKEEFEHQQK 14 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 157456600.0 2965600.0 91364000.0 63127000.0 False True 3887930.3189112525 77732847.33408265 56595223.59694246 1.0 19.993374612704063 14.55664555551782 21.890570931924753 -9.718769053349272 8.834875927646017 1.0000004527251853 17.275010084110967 0.9227697467831653 2.219535343311513 0.0 0.0 2.149055791194229 0.7163519517470178 1.9108691395607991e-10 9.718769053349272 16.27500963138578 NQTAEKEEFEHQQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQTAEKEEFEHQQK 14 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 144455000.0 45750000.0 13585000.0 85120000.0 False True 44297691.29228389 19009561.344839092 62824518.454736345 1.0 0.4291321012512975 1.4182345991850729 25.40072817455012 -6.750184993413651 1.6489817164096015 0.6644053414145135 1.4202521061992897 0.6498601786873637 0.2398850987668866 0.2997116035119553 1.6034561966455196 0.11491217254133047 0.27894104435292116 1.777522089977056e-07 6.750184993413651 0.7558467647847762 NQTAEKEEFEHQQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQTAEKEEFEHQQK 14 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 476303100.0 2270800.0 470660000.0 3372300.0 False True 3444969.617717189 386667045.71663594 2705763.4268683996 1.0 112.2410612064733 0.7854244673023779 21.7160598287234 -13.999968582162753 1.529296468199494e-19 9.187702861447406 92.73613424495065 0.0 54.06479812406854 0.0 0.23925846327455688 77.51176768326928 77.51176567185846 1.000072344860463e-14 13.999968582162753 83.54843138350324 NQTAEKEEFEHQQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQTAEKEEFEHQQK 14 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 156033600.0 2965600.0 72191000.0 80877000.0 False True 4062062.4623265844 69001362.9162871 61775518.31410011 1.0 16.986780374806425 15.207919348122875 21.953780993447644 -9.932465158066744 10.546322045547802 1.00000000034106 16.097349945579676 0.9896950646937845 0.7262169731163549 0.0 0.0 0.7031565606532049 0.23438552021773493 1.1682474505247617e-10 9.932465158066744 15.097349945238616 NQTAEKEEFEHQQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQTAEKEEFEHQQK 14 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 48753400.0 45750000.0 1857500.0 1145900.0 False True 38043152.06864692 1847493.2788151181 1385502.3919570278 1.0 0.048563096861201485 0.03641923228277614 25.181133449984397 NQTAEKEEFEHQQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NQTAEKEEFEHQQK 14 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 10679100.0 2270800.0 4384600.0 4023700.0 False True 2939595.364159964 4140593.1556268344 3291427.8866484603 1.0 1.4085588806233795 1.11968739874137 21.487186150815848 -10.437483906416581 9.070909649391629 0.9999979142392676 1.2641231396823747 0.5271106738773688 0.11793128864209317 4.974611957807204e-06 3.085721429568722e-07 0.11418738081776557 0.03806215974230059 3.6518765970670255e-11 10.437483906416581 0.264125225443107 NQTAEKEEFEHQQK(ub)ELEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQTAEKEEFEHQQKELEK 18 2 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 687319600.0 219950000.0 358281200.0 109088400.0 True False 288356579.9988301 304827041.5291789 97800978.8178227 1.0 1.0571183828384136 0.3391668011120797 28.10327870267781 -6.887652829035502 1.0361974648232515 1.0407750883813827 0.28018961720077695 0.9793518283155093 0.04681835380716085 0.1210669802669637 0.2331525663648398 0.034529328548930635 0.08538363372756336 1.2952308231758002e-07 6.887652829035502 -0.7605854711806057 down NQTAEKEEFEHQQK(ub)ELEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQTAEKEEFEHQQKELEK 18 2 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 706655400.0 237409100.0 225497100.0 243749200.0 True False 229872678.07167086 315539267.9818415 179903972.20074275 1.0 1.3726697345191283 0.782624423702287 27.776259761244958 -6.736024703148523 1.7012695674759877 1.222758750903872 0.7825735437951856 0.5868917775211177 0.156602436007563 0.32509020138380246 1.845886824869455 0.07286820632285587 0.17959696270163594 1.8364338819953246e-07 6.736024703148523 -0.44018520710868636 NQTAEKEEFEHQQK(ub)ELEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQTAEKEEFEHQQKELEK 18 2 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 711995900.0 32689500.0 392550000.0 286756400.0 True False 49592361.422567405 322496385.4928513 230078871.85020489 1.0 6.502944732655879 4.6394014168784 25.56361458751645 -9.748199312062052 8.719762009042325 0.9999999999453647 5.571173074767136 0.8891671895612604 0.760788372871516 0.0 0.0 0.7366301690415822 0.24554339150996812 1.7856678848861142e-10 9.748199312062052 4.571173074821772 NQTAEKEEFEHQQK(ub)ELEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQTAEKEEFEHQQKELEK 18 2 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 655655000.0 219950000.0 288995000.0 146710000.0 True False 301271458.9252538 276226245.3213337 112060119.58729462 1.0 0.9168682831979319 0.37195730384502507 28.1664887642007 -6.933993626918351 0.7132507987208279 1.0071860488930866 0.24779349012260102 0.9972665462055155 0.01456291412741916 0.09061662170906251 0.06790629230255023 0.013598087924892704 0.048268252457810454 1.1641431125763622e-07 6.933993626918351 -0.7593925587704856 down NQTAEKEEFEHQQK(ub)ELEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQTAEKEEFEHQQKELEK 18 2 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 649098000.0 237409100.0 309799500.0 101889400.0 True False 197416185.65640637 308130548.6031136 123194002.45664226 1.0 1.5608170504286836 0.6240319254828256 27.556665036679235 -6.744586125246971 1.6700867469820393 1.3319008146023117 0.6229341677695249 0.6252846405302619 0.2356216949548646 0.30957531671259625 1.697096081188176 0.1115394622049714 0.2723229806718801 1.8005860235412388e-07 6.744586125246971 -0.7089666468327868 NQTFK(ub)SEQSSDDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQTFKSEQSSDDLR 14 1 Q7Z7G8-2;Q7Z7G8-6;Q7Z7G8 Q7Z7G8-2 VPS13B Vacuolar protein sorting-associated protein 13B 1 3786200.0 1162500.0 1413200.0 1210500.0 True False 1524048.7576660141 1202356.0686104537 1085249.0719359212 1.0 0.7889223114172458 0.7120829084221115 20.539477627875716 -13.999999999999998 0.14054952256530068 2.0087821132833508 0.6176167442412759 0.9996007500406309 0.0024322237969605044 11.93456641033474 0.11749900154054908 3.3009060070970615 0.08448290089557937 1.0000000000000041e-14 13.999999999999998 -1.3911653690420749 NQTFK(ub)SEQSSDDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQTFKSEQSSDDLR 14 1 Q7Z7G8-2;Q7Z7G8-6;Q7Z7G8 Q7Z7G8-2 VPS13B Vacuolar protein sorting-associated protein 13B 1 5402300.0 1354900.0 1440200.0 2607200.0 True False 1311889.441134764 2015279.3705437814 1924296.1056765607 1.0 1.5361655543172874 1.4668127094704522 20.32321471195744 -10.57223061037317 6.219369550620589 0.9989040134900377 1.50148913189384 0.9858589526670203 0.028313180347526022 0.0004311051459646096 2.9651440270664907e-05 0.02746724043574721 0.009138039663677957 2.677746064061977e-11 10.57223061037317 0.5025851184038023 NQTFK(ub)SEQSSDDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQTFKSEQSSDDLR 14 1 Q7Z7G8-2;Q7Z7G8-6;Q7Z7G8 Q7Z7G8-2 VPS13B Vacuolar protein sorting-associated protein 13B 1 4143900.0 1162500.0 1374500.0 1606900.0 True False 1592307.6653812567 1313770.0451363274 1227383.315144325 1.0 0.825072989158639 0.7708204524974415 20.602687689398607 -13.999999999992529 0.16393374553427126 1.8690387134714963 0.7197364828943877 0.9995265757136653 0.0021277391248508202 12.038180247769528 0.12807183610428002 3.3258981979635824 0.04679906627449499 1.0000000000172035e-14 13.999999999992529 -1.1493022305771086 NQTFK(ub)SEQSSDDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQTFKSEQSSDDLR 14 1 Q7Z7G8-2;Q7Z7G8-6;Q7Z7G8 Q7Z7G8-2 VPS13B Vacuolar protein sorting-associated protein 13B 1 5400200.0 1354900.0 2903800.0 1141500.0 True False 1126659.3822472072 2888156.653040831 1380182.3723003315 1.0 2.5634692246384034 1.2250218602426703 20.103619987391717 -6.608291795546705 2.1595878687222068 2.045736956986484 1.2296958145293937 0.04520248434140861 0.674351639277574 0.6174190605506912 5.453885008678322 0.2580573644975102 0.7490594331787962 2.4643830011679727e-07 6.608291795546705 -0.8160411424570904 NQVALNPQNTVFDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQVALNPQNTVFDAK 15 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 33821500.0 1484500.0 17899000.0 14438000.0 False True 1946193.875918448 15228538.969755523 12944094.259075442 1.0 7.824780027410614 6.650978825512368 20.892224004979614 -10.4518070835411 6.653280637078465 0.9985947433232523 7.237879426461491 0.9741301798224711 0.47920233401938656 0.009986367091868481 0.0008228182819391802 0.46387372482097766 0.15466188826006727 3.5334009092384575e-11 10.4518070835411 6.239284683138239 NQVALNPQNTVFDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQVALNPQNTVFDAK 15 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 34359600.0 9114500.0 4253100.0 20992000.0 False True 8825165.186525052 5951385.009623493 15493565.453498904 1.0 0.6743652819904754 1.7556119490154907 23.073191851849653 -6.825943244519492 1.3458521812095463 0.8254507604381041 1.7823849390656161 0.8975217040086418 0.14498402629017706 0.18587876769748943 0.6598642192038497 0.08461340480503288 0.19479270933658643 1.4929895071541514e-07 6.825943244519492 0.9569341786275121 NQVALNPQNTVFDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NQVALNPQNTVFDAK 15 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 294117200.0 0.0 287900000.0 6217200.0 False True 0.0 236521995.627033 4988367.694904432 0.0 NQVALNPQNTVFDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQVALNPQNTVFDAK 15 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 38663500.0 1484500.0 20943000.0 16236000.0 False True 2033359.7671040632 20017669.01076032 12401391.190916196 1.0 9.844627268921396 6.098965560127323 20.955434066502505 -9.714789067745333 8.452220424250791 0.9999999999055814 7.971796414513068 0.8220401596066063 1.5291599892711414 0.0 0.0 1.4806027820021064 0.49353426434448544 1.9284613191180781e-10 9.714789067745333 6.9717964146074864 NQVALNPQNTVFDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQVALNPQNTVFDAK 15 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 9114500.0 9114500.0 0.0 0.0 False True 7579110.590812722 0.0 0.0 1.0 0.0 0.0 22.85359712728393 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 NQVALNPQNTVFDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NQVALNPQNTVFDAK 15 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 13972800.0 0.0 6504300.0 7468500.0 False True 0.0 6142329.987260783 6109309.633281308 0.0 NQVALNPQNTVFDAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQVALNPQNTVFDAKR 16 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 109235000.0 54249000.0 36839000.0 18147000.0 True False 52526895.18940129 51549004.81284717 13393756.301669415 1.0 0.9813830538997584 0.2549885397447204 25.64655297500848 -6.91240410226415 0.8792050769350888 1.0208173628785913 0.15612257338576568 0.9917974460929855 0.03141774881530398 0.10285006312070474 0.13030386031759528 0.026031764088161623 0.07311453065570513 1.2234772485358169e-07 6.91240410226415 -0.8646947894928256 down NQVALNPQNTVFDAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NQVALNPQNTVFDAKR 16 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 102501100.0 54249000.0 32869100.0 15383000.0 True False 45110447.13818638 32692027.63429449 18599514.177044235 1.0 0.7247107867086604 0.4123105701007248 25.426958250442755 -6.969479453674692 0.27033507049212036 1.0773457064046401 0.050279823723371926 0.9999780306160669 0.0011252885941432243 0.07647203026243136 0.009633229290198077 0.006111214172665776 0.029041563607470382 1.0728044006489542e-07 6.969479453674692 -1.0270658826812682 down NQVAMNPTNTVFDAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 NQVAMNPTNTVFDAK 15 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 151984400.0 6129600.0 82131200.0 63723600.0 False True 8035964.9591308385 69877545.10491015 57130093.151933745 1.0 8.695601021195596 7.109300929320239 22.938039842529477 -9.78084692686149 10.831649536492186 1.0000000005678435 7.902450962735338 0.9618974472591539 0.6476043006707837 0.0 0.0 0.6270401678575614 0.20901338928585378 1.6563536655137648e-10 9.78084692686149 6.902450962167494 NQVAMNPTNTVFDAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 NQVAMNPTNTVFDAK 15 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 142793600.0 35554300.0 21080800.0 86158500.0 False True 34425648.20793985 29498473.37491972 63591004.15040424 1.0 0.8568748857462694 1.8471984540798787 25.036980483642974 -6.870224253118418 1.1329698543265379 0.9189500413212427 1.9054290998393708 0.9649033754726466 0.08187393565912458 0.13663682017826995 0.32767716548109405 0.05607760810106838 0.13281203802233665 1.3482665093771613e-07 6.870224253118418 0.9864790585181281 NQVAMNPTNTVFDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NQVAMNPTNTVFDAK 15 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 151724600.0 6129600.0 75145500.0 70449500.0 False True 8395878.766211571 71825323.3370621 53810779.05299645 1.0 8.554830928016303 6.409189621645431 23.00124990405237 -9.374255982003758 8.035194425826763 0.999999310177861 7.482010274841413 0.9240623179404637 0.8759543952986492 0.0 0.0 0.8481391962464205 0.2827130654154734 4.224195581913388e-10 9.374255982003758 6.4820109646635515 NQVAMNPTNTVFDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NQVAMNPTNTVFDAK 15 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 42307700.0 35554300.0 3955200.0 2798200.0 False True 29564975.772552837 3933892.552554265 3383290.682585002 1.0 0.13305921786705346 0.11443576712570619 24.81738575907725 NQVAMNPTNTVFDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NQVAMNPTNTVFDAK 15 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 0 25739900.0 7940200.0 9012200.0 8787500.0 False True 10278745.424741464 8510663.14763951 7188265.1673642015 1.0 0.8279865680060438 0.6993329312409743 23.29316085092644 -6.974323165950256 0.11487191764652341 1.2504837902933934 0.27354161800290344 0.9999995395350431 8.338156995551931e-05 0.07492301361650494 0.00340738605703863 0.00962794690507495 0.019108755190223987 1.0609058252429854e-07 6.974323165950256 -0.97694217229049 NQVAMNPTNTVFDAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 2 NQVAMNPTNTVFDAKR 16 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 88035100.0 31152300.0 43629300.0 13253500.0 True False 40840966.97930231 37119978.505679436 11882154.95654912 1.0 0.9088907842091833 0.29093716029228317 25.283513689088583 -6.933299237123321 0.719192593514544 1.0083442427021918 0.1527126018669554 0.9971479140515146 0.016821727729303033 0.0909605060526675 0.06955002123999163 0.01563807927294642 0.05493505610795159 1.1660059400422384e-07 6.933299237123321 -0.8556316408352365 down NQVAMNPTNTVFDAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 2 NQVAMNPTNTVFDAKR 16 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 156866600.0 66574300.0 57371900.0 32920400.0 True False 64460935.28742947 80280798.8605061 24297559.649169456 1.0 1.2454178410930017 0.3769346432971742 25.941921785354065 -6.831246274619765 1.3225080480090068 1.131021447765901 0.35299265307323907 0.9083113033197938 0.1106919192212598 0.17927978693060023 0.612838740845659 0.06571120714514958 0.15120268359539202 1.4748699441516092e-07 6.831246274619765 -0.7780287946926621 down NQVAMNPTNTVFDAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 2 NQVAMNPTNTVFDAKR 16 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 205419900.0 77757900.0 38103000.0 89559000.0 True False 117964419.16394734 31303221.94990222 71857624.39489588 1.0 0.26536155708440273 0.6091465961022359 26.813776533631287 -10.604183461813145 6.549249820703543 1.00143883490812 0.43725407659586085 0.7813080512847304 0.14034965446608283 0.0029547429586614118 0.00017857514589582213 0.13617612575125787 0.04529765619942534 2.487806156307132e-11 10.604183461813145 -0.5641847583122592 NQVAMNPTNTVFDAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NQVAMNPTNTVFDAKR 16 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 91133800.0 31152300.0 39657900.0 20323600.0 True False 42670147.169252895 37905682.84686204 15523584.257680744 1.0 0.8883419758668183 0.36380432896342746 25.346723750611474 -6.941206501298756 0.6482524124173704 1.0057871561464073 0.21719229876602716 0.9983175658128896 0.01137656799041979 0.08722078510574041 0.052137432195231 0.011178121658891158 0.04491143580122302 1.1449683946213519e-07 6.941206501298756 -0.7885948573803802 down NQVAMNPTNTVFDAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NQVAMNPTNTVFDAKR 16 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 147712100.0 66574300.0 67786600.0 13351200.0 True False 55359480.19155678 67421420.13121344 16142874.191025967 1.0 1.2178839089153208 0.29160089898185165 25.72232706078834 -6.844696744491855 1.2602854862586264 1.1159462317894029 0.258168545685807 0.9322388756617727 0.10293494515819425 0.16339369394605555 0.5020629500646813 0.06398634623305541 0.14766204021341836 1.4298920630329668e-07 6.844696744491855 -0.857777686103596 down NQVAMNPTNTVFDAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NQVAMNPTNTVFDAKR 16 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25 P11142 HSPA8 Heat shock cognate 71 kDa protein 1 212922900.0 77757900.0 78685000.0 56480000.0 True False 100659134.38735877 74306110.580326 46201219.5337389 1.0 0.738195406036173 0.4589868551416936 26.584902855723737 -6.970308169610609 0.25072632655028626 1.0878197699117536 0.10117739383144235 0.9999846839907818 0.0008645103749138944 0.07620291667940315 0.008672093420307458 0.0061968630535140555 0.02672783041701483 1.0707592390329769e-07 6.970308169610609 -0.9866423760803112 down NQYDNDVTVWSPQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQYDNDVTVWSPQGR 15 0 P25786;P25786-2;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 11123200.0 1130300.0 5553900.0 4439000.0 False True 1481834.2458407695 4725279.768932645 3979694.8618947156 1.0 3.1888045388312616 2.685654534618141 20.49895264984416 -10.341288407752947 5.799768491208206 0.9997070413374833 2.937229536724707 0.9518430045243015 0.20541012906691286 0.0007782143955491352 8.838667501597952e-05 0.1989144983369532 0.0662958340848694 4.5573416994440654e-11 10.341288407752947 1.9375224953872239 NQYDNDVTVWSPQGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NQYDNDVTVWSPQGR 15 0 P25786;P25786-2;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 10722400.0 2948400.0 1025800.0 6748200.0 False True 2854804.655872561 1435407.289476331 4980643.978339426 1.0 0.5028040312753392 1.7446531650051236 21.44496059979995 -6.798064756138874 1.4639665417988725 0.7249988975876308 1.7609570547696622 0.8263995554094721 0.2126296549655872 0.22353129867676913 0.9460205042569211 0.11427666694209127 0.2660653485681133 1.5919713360473965e-07 6.798064756138874 1.0359581571820313 NQYDNDVTVWSPQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQYDNDVTVWSPQGR 15 0 P25786;P25786-2;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 11626400.0 1130300.0 4227300.0 6268800.0 False True 1548202.455208975 4040523.908188286 4788238.549988635 1.0 2.609816238563515 3.0927728695161663 20.56216271136705 -9.866025364149417 0.3083886830374482 1.3794376044018937e-11 3.253545803048955 0.9988136259524183 0.030816980550257694 1.24913357805764 0.13469238252736307 1.3164622061925892 0.16552734184149012 1.3613651721810567e-10 9.866025364149417 3.2535458030351605 NQYVTLHDMILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NQYVTLHDMILK 12 0 P61289;P61289-3;P61289-2;K7ESG5;K9J957;B3KQ25;A0A087WTV2 P61289 PSME3 Proteasome activator complex subunit 3 0 8029600.0 1556000.0 3375800.0 3097800.0 False True 2039931.0683254332 2872143.798765339 2777269.3721958646 1.0 1.407961201906231 1.36145255852969 20.96008897197915 -10.093722647586025 4.490973324294858 0.9999680992040952 1.3847068802077505 0.9891573824371114 0.018987074218550285 13208430.137787519 0.37873440421017085 4471.657532412272 0.006499780521344011 8.058929423166486e-11 10.093722647586025 0.3847387810036552 NQYVTLHDMILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NQYVTLHDMILK 12 0 P61289;P61289-3;P61289-2;K7ESG5;K9J957;B3KQ25;A0A087WTV2 P61289 PSME3 Proteasome activator complex subunit 3 0 8241000.0 1556000.0 2991900.0 3693100.0 False True 2131295.2493189103 2859707.965109766 2820865.841782004 1.0 1.3417699711119948 1.3235453148424448 21.02329903350204 -10.095462195720021 4.657636016677953 0.9999796301267497 1.332657642984118 0.9977540055050117 0.007440184789942776 5176684.717436476 0.10594111272763199 1130.8947616305543 0.0025469731473719936 8.026714284302645e-11 10.095462195720021 0.3326780128573682 NREPVQLETLSIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NREPVQLETLSIR 13 1 P62314;J3QLI9 P62314 SNRPD1 Small nuclear ribonucleoprotein Sm D1 0 28063000.0 2577000.0 12029000.0 13457000.0 False True 3378471.9557034974 10234320.088674752 12064598.728658965 1.0 3.0292748387025354 3.571022310335194 21.68793944885258 -9.77691472010229 0.34859659580381336 2.6608720095211652e-24 3.6935582478862172 0.9986653350924113 0.040428463114354427 1.1262499473181842 0.14992978420415243 1.3925280843079064 0.16017323758153862 1.6714187889375616e-10 9.77691472010229 3.6935582478862172 NREPVQLETLSIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NREPVQLETLSIR 13 1 P62314;J3QLI9 P62314 SNRPD1 Small nuclear ribonucleoprotein Sm D1 0 16630500.0 7221700.0 2156200.0 7252600.0 False True 6992451.086458714 3017181.904434453 5352926.486663786 1.0 0.4314913135792112 0.7655293430697052 22.73736682613143 -10.299630937472678 5.927125505107007 1.0000283464739392 0.5985103283244748 0.6582568995800282 0.13637045448941548 5.1085422787875106e-05 6.036162739112289e-06 0.13204942743696052 0.04401337492935299 5.016133224918456e-11 10.299630937472678 -0.4015180181494644 NREPVQLETLSIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NREPVQLETLSIR 13 1 P62314;J3QLI9 P62314 SNRPD1 Small nuclear ribonucleoprotein Sm D1 0 28993000.0 2577000.0 14646000.0 11770000.0 False True 3529786.540806448 13998891.292154713 8990168.410759035 1.0 3.96593140415692 2.5469439318291065 21.75114951037547 -9.72525800081812 14.528369261969706 0.9999935192192261 3.256426076622143 0.7712476526483013 0.5792992098568633 0.0 0.0 0.5609040481610262 0.18696801605367536 1.8825304045852327e-10 9.72525800081812 2.256432557402917 NRPEDYQGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NRPEDYQGGR 10 1 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 30977760.0 704760.0 17483000.0 12790000.0 False True 923947.1849055481 14874604.548200242 11466613.490343181 1.0 16.0989770748864 12.410464231800622 19.817450860436818 -9.713955733752305 8.35137285228684 1.0000333415412572 14.25472065334346 0.9451085865851162 1.5058290626668387 0.0 0.0 1.4580128507824999 0.4860042401434466 1.9321652464051877e-10 9.713955733752305 13.254687311802202 NRPEDYQGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NRPEDYQGGR 10 1 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 14052300.0 4851800.0 2237800.0 6962700.0 False True 4697782.264741053 3131365.2099728384 5138959.993477368 1.0 0.666562440212508 1.0939119150003078 22.163548417442733 -6.69852787189789 1.836193852223609 0.7926479200293937 1.092602343437577 0.4105350974731522 0.14078682266141943 0.3986060228404531 2.6117990819305867 0.06119327615935349 0.15765520990179058 2.0020371318949628e-07 6.69852787189789 0.29995442340818324 NRPEDYQGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NRPEDYQGGR 10 1 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 25074760.0 704760.0 13174000.0 11196000.0 False True 965328.8174228766 12591929.119407753 8551735.38885796 1.0 13.044186490800337 8.858883350948123 19.88066092195971 -9.964693273511832 11.439540622062662 0.9999999794506814 10.95153492087442 0.8828786727800512 1.7086428519177046 0.0 0.0 1.6543863275234043 0.551462109174468 1.0846927228046936e-10 9.964693273511832 9.95153494142374 NRPHICSFWVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NRPHICSFWVK 11 1 E5RJW4;Q9NW64-2;Q9NW64 E5RJW4 RBM22 Pre-mRNA-splicing factor RBM22 0 20787700.0 6501300.0 3585400.0 10701000.0 False True 8523267.258678759 3050472.295779737 9593763.171240224 1.0 0.3578994067883551 1.1255968961282352 23.022975139954262 -6.684798294281972 1.884744488825418 0.5954990286281393 1.1228000134510654 0.3462386890149469 0.27185668848578454 0.42796227963579725 2.9431638167089615 0.11556497983016156 0.3029446089782649 2.0663396332233034e-07 6.684798294281972 0.5273009848229261 NRPHICSFWVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NRPHICSFWVK 11 1 E5RJW4;Q9NW64-2;Q9NW64 E5RJW4 RBM22 Pre-mRNA-splicing factor RBM22 0 16767400.0 6501300.0 4745200.0 5520900.0 False True 8905006.301026376 4535541.37372201 4216977.126504636 1.0 0.5093248921339057 0.47355127935379393 23.086185201477154 -13.999999999999993 0.3716261927356129 7.904986531346566 0.4699367945703372 0.9997936713434018 0.0034500159319706975 23.010971368575756 0.19801786510526684 126.66842250785196 0.009947373045440529 1.0000000000000164e-14 13.999999999999993 -7.435049736776229 NRPSSGSLIQVVTTEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NRPSSGSLIQVVTTEGR 17 1 P09417;P09417-2 P09417 QDPR Dihydropteridine reductase 0 12166800.0 2935400.0 3190600.0 6040800.0 False True 3848337.826454035 2714574.91686139 5415755.963445276 1.0 0.7053889339446778 1.4072974379267278 21.87580402101969 -6.7926855743027375 1.4855030594082972 0.835910780036847 1.4153324953831934 0.809912612542146 0.1254697825520159 0.23138270754003584 1.0086050803601612 0.0664706737896089 0.1553308400905572 1.6118121518329166e-07 6.7926855743027375 0.5794217153463463 NRPSSGSLIQVVTTEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NRPSSGSLIQVVTTEGR 17 1 P09417;P09417-2 P09417 QDPR Dihydropteridine reductase 0 12077800.0 2935400.0 4235800.0 4906600.0 False True 4020696.70620227 4048648.350082545 3747762.1345990035 1.0 1.0069519404030542 0.9321175926594409 21.93901408254258 -6.884165622803544 1.0562587684237343 1.0046010747020275 0.9263707975822005 0.9768944981931977 0.005131406417571111 0.12400568921100674 0.2505124442257489 0.0037270500238232793 0.009116621184444987 1.3056728609901996e-07 6.884165622803544 -0.078230277119827 NRPTSISWDGLDSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NRPTSISWDGLDSGK 15 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 92409500.0 9824500.0 42686000.0 39899000.0 False True 12880014.640593324 36317415.188724816 35770634.218233176 1.0 2.819671887193743 2.777219996745701 23.618630897563087 -10.056780567739446 4.614453016785478 0.9999207171930196 2.79844594201554 0.9995822858684921 0.01733091194293456 1372848.8156619472 1496000.5496215275 905.7003446251929 0.005932832032135578 8.774440478152413e-11 10.056780567739446 1.7985252248225203 NRPTSISWDGLDSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NRPTSISWDGLDSGK 15 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 73074100.0 21692000.0 12065100.0 39317000.0 False True 21003399.3336005 16882757.348665312 29018698.215282787 1.0 0.8038107108527366 1.3816191252841483 24.3241195066192 -6.815095226600738 1.3930045432113118 0.8937020110199987 1.3929495468208668 0.8727105099582488 0.08559216484684506 0.19993832525360838 0.7636303108530968 0.04830037185004645 0.11149379736921064 1.5307517809929282e-07 6.815095226600738 0.4992475358008681 NRPTSISWDGLDSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NRPTSISWDGLDSGK 15 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 76562500.0 9824500.0 28711000.0 38027000.0 False True 13456883.147129582 27442453.085419476 29045805.790648587 1.0 2.039287462436878 2.158434867352192 23.681840959085978 -10.836383545970726 0.40692100759293715 3.7730083367646224e-11 2.1668705580269543 0.9994805757028574 0.011857795273406087 2.4985569808623835 0.1973831306487003 2.440933312687257 0.02983001666275147 1.4575264812284388e-11 10.836383545970726 2.166870557989224 NRPTSISWDGLDSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NRPTSISWDGLDSGK 15 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 32771100.0 21692000.0 6730300.0 4348800.0 False True 18037859.11853748 6694042.538040051 5258113.973420652 1.0 0.37111070077937325 0.29150432647613356 24.104524782053478 -13.999999999999998 0.2914329622634871 6.463120512090014 0.27012282512065094 0.9996306698883624 0.006090084092145389 16.051529022523063 0.17122750283218566 52.618129360847945 0.029872116220326102 1.0000000000000041e-14 13.999999999999998 -6.192997686969363 NRPTSISWDGLDSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NRPTSISWDGLDSGK 15 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 30159700.0 10150600.0 13798900.0 6210200.0 False True 13140151.79823945 13030979.084792027 5080007.322033027 1.0 0.9916916703000302 0.386601874927629 23.64747860633314 -6.909890688238666 0.896464026504994 1.018799950438659 0.308582899083709 0.9908805024483903 0.02742841467976077 0.1044910174522481 0.13915445916688896 0.022443819744392902 0.06190945706010257 1.2305784679831213e-07 6.909890688238666 -0.71021705135495 down NSALSAQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSALSAQLR 9 0 P47897;P47897-2;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RQU2;F2Z2V6;A0A0U1RQC3 P47897 QARS Glutamine--tRNA ligase 0 5928600.0 1686200.0 1815700.0 2426700.0 False True 2309633.707841612 1735476.3702830342 1853563.439455307 1.0 0.7514076212131764 0.8025356718522655 21.139232637509956 -10.685239340445898 6.712205262680156 1.001720370245347 0.7769716465327213 0.9620797927232889 0.020872939268157944 0.0005411324518330004 2.5375739130991634e-05 0.020351677638127286 0.006736712180997887 2.0642422347908894e-11 10.685239340445898 -0.22474872371262566 NSAQGNVYVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSAQGNVYVK 10 0 Q14498-3;Q14498-2;Q14498;H0Y4X3 Q14498-3 RBM39 RNA-binding protein 39 0 4834070.0 1859700.0 282270.0 2692100.0 False True 1800664.8414483124 394981.8830186039 1986958.2487311568 1.0 0.21935335989617685 1.103458124463076 20.78009824608329 -6.6735756799806465 1.9243424195025964 0.5032727468654183 1.0999763412925492 0.29516607302952047 0.3313279296709794 0.4529404200642294 3.236853061607829 0.13843419214155273 0.36819331047735426 2.1204318552963636e-07 6.6735756799806465 0.5967035944271308 NSAQGNVYVK(ub)CPSIAAAIAAVNALHGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSAQGNVYVKCPSIAAAIAAVNALHGR 27 1 Q14498-3;Q14498-2;Q14498 Q14498-3 RBM39 RNA-binding protein 39 1 29986300.0 4222500.0 8921800.0 16842000.0 True False 6405841.206099541 7329635.083658429 13513171.317889156 1.0 1.1442111734957254 2.109507695105231 22.610956605024633 -6.933566629039762 0.7169137702060119 0.9870848064466065 2.3269642664721855 0.9971939491833267 0.02609235019676903 0.09082765297937449 0.06891511136260657 0.024297484031310074 0.08569427760601633 1.165288259723759e-07 6.933566629039762 1.339879460025579 up NSAQGNVYVK(ub)CPSIAAAIAAVNALHGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSAQGNVYVKCPSIAAAIAAVNALHGR 27 1 Q14498-3;Q14498-2;Q14498 Q14498-3 RBM39 RNA-binding protein 39 1 26383200.0 4222500.0 4768700.0 17392000.0 True False 5466109.487918555 4503317.652975801 14226834.456989834 1.0 0.8238615898436064 2.602734996149388 22.382082927117082 -6.882548256226794 1.0654420599683925 0.8866593267499181 2.735151331513038 0.975685245042368 0.1247907126071722 0.12539868394983034 0.25882595160505245 0.09000492976396952 0.21914304872584553 1.3105444143537887e-07 6.882548256226794 1.84849200476312 up NSASLFTASDYK(ub)VASAEYHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSASLFTASDYKVASAEYHR 20 1 A0A0A0MT59;Q15014 A0A0A0MT59 MORF4L2 Mortality factor 4-like protein 2 1 25167100.0 5411700.0 12465000.0 7290400.0 True False 7005552.330555076 11771311.792384384 5963622.005820992 1.0 1.6802831863867755 0.8512707812930537 22.74006736917935 -6.688647410954728 1.8711335051797182 1.427041440988674 0.8541805107792544 0.3640637624513049 0.287793053475075 0.4196281121822689 2.8473871536382713 0.12308906700446401 0.32109051089175394 2.0481067507341569e-07 6.688647410954728 -0.5728609302094196 NSATEAAK(ub)PAKPDEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSATEAAKPAKPDEK 15 2 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 1 2954420.0 1162000.0 1342100.0 450320.0 True False 1523393.2528240054 1141863.9114648257 403725.20617445983 1.0 0.7495529531511868 0.2650170633393907 20.538856980397487 -7.007598303359749 0.4377298274087674 1.0181242045629737 1.892517504191383e-11 0.9997870891957551 0.004451651346408838 0.07434258731643945 0.020757363948769442 0.0062866590075235495 0.037532011985226627 9.826564217251456e-08 7.007598303359749 -1.0181242045440486 down NSATEAAK(ub)PAKPDEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSATEAAKPAKPDEK 15 2 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 1 3998250.0 1808500.0 1456900.0 732850.0 True False 1751090.1574228506 2038647.7676331329 540894.5999712587 1.0 1.1642163363155968 0.30889020629715314 20.739821934259766 -6.856952732018638 1.2009917672955885 1.088472576873995 0.26980697466951664 0.9498384439428694 0.08300524717690286 0.14996749077306837 0.4127704624359144 0.05396798172120383 0.12557990585394513 1.3901039198741435e-07 6.856952732018638 -0.8186656022044783 down NSATEAAK(ub)PAKPDEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSATEAAKPAKPDEK 15 2 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 1 3677090.0 593860.0 509630.0 2573600.0 True False 900929.0369814724 418682.544742636 2064926.8319510475 1.0 0.46472311087387697 2.291997201987744 19.78105394892536 -6.828295318725941 1.3356264074472712 0.7136336938436942 2.3394384107803194 0.9023992516779141 0.239621816189861 0.18292511864515326 0.6388132302165311 0.14089246809242176 0.3242440119102636 1.4849255547238422e-07 6.828295318725941 1.6258047169366252 up NSATEAAK(ub)PAKPDEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSATEAAKPAKPDEK 15 2 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 1 3461760.0 1808500.0 1341200.0 312060.0 True False 1503847.8801343816 1333974.6893926437 377310.30319758336 1.0 0.8870409746984793 0.2508965887985076 20.520227209694042 -6.9371908559225215 0.6852029653216846 1.0076054959061131 0.09265660617172959 0.9977722561356877 0.015563702319355666 0.08907202964393174 0.06062380079975838 0.014845111212589399 0.055463278833923706 1.1556042864132908e-07 6.9371908559225215 -0.9149488897343836 down NSATEAAK(ub)PAKPDEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSATEAAKPAKPDEK 15 2 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 1 6197920.0 593860.0 434460.0 5169600.0 True False 768763.4767306828 410281.91907896666 4228785.844575357 1.0 0.5336907013634036 5.500763202954303 19.55218027101781 -6.8839113959472 1.0577688056385637 0.6928732308606307 5.880247111278942 0.9767049500116978 0.3418383620523919 0.12422069541885586 0.2518404919556738 0.2480070832862857 0.6061588737322777 1.3064373981744383e-07 6.8839113959472 5.187373880418312 up NSDDIDK(ub)QYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSDDIDKQYR 10 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 4420940.0 1215100.0 1039000.0 2166840.0 True False 1593007.8670451401 883985.2499902804 1942636.1825969697 1.0 0.5549158094429119 1.2194768292013227 20.603321960932522 -6.726204610422262 1.7368071707187955 0.7310278336202782 1.2188341105475569 0.5416879016222274 0.18716543504261066 0.34340611106269425 2.027525830428351 0.0854567677501865 0.2129936181545625 1.8784316173456624e-07 6.726204610422262 0.4878062769272786 NSDDIDK(ub)QYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSDDIDKQYR 10 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 7315700.0 833800.0 2958500.0 3523400.0 True False 807331.4753990441 4139844.478373684 2600515.840265725 1.0 5.127812558438231 3.2211252992215544 19.622801613525017 -9.210792839241996 10.852880436042401 1.00000000000444 4.174468928912448 0.7870489541170407 0.7784018140245307 0.0 0.0 0.7536843155936203 0.25122810519787336 6.154703853200874e-10 9.210792839241996 3.1744689289080084 NSDDIDK(ub)QYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSDDIDKQYR 10 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 21956300.0 5744100.0 10706100.0 5506100.0 True False 8714219.649960069 8795512.807858909 4417816.921590639 1.0 1.0093287937605764 0.5069664409492918 23.054940047497425 -6.902669777025267 0.9442309793932778 1.0193840877847797 0.4512792915216727 0.9878485036788484 0.025866143351533862 0.10946685030118987 0.1665419415052527 0.02043766822435981 0.05392449184331541 1.2512100468141113e-07 6.902669777025267 -0.5681047962631071 NSDDIDK(ub)QYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSDDIDKQYR 10 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 6321700.0 1215100.0 2140600.0 2966000.0 True False 1664355.30684281 2046021.2139824093 2265491.8866874515 1.0 1.2293175655284798 1.3611828420128418 20.666532022455414 -12.073467164157055 0.07614465651532125 6.275967223460136e-15 1.8287932401326616 0.999937531302876 0.0011794621510815807 5.966097665408182 0.05852613735711506 1.3249058852647215 0.3516516550788899 8.443700800566023e-13 12.073467164157055 1.8287932401326554 NSDDIDK(ub)QYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSDDIDKQYR 10 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 5113700.0 833800.0 1960300.0 2319600.0 True False 693341.6436030113 1949739.4748109165 2804617.6353813796 1.0 2.8120905368945137 4.045073105384144 19.403206888959293 -8.163730100184642 0.22316421429626138 1.0360267289755933e-17 5.342364868194521 0.999674307310978 0.022569833534500715 0.0901778684806473 0.04705199999207354 0.4138905060325899 0.4784498831998204 6.85914367366677e-09 8.163730100184642 5.342364868194521 NSDDIDK(ub)QYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSDDIDKQYR 10 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 18067500.0 5744100.0 7550200.0 4773200.0 True False 7435850.683138658 7130024.732840796 3904526.577167887 1.0 0.9588714239526964 0.525094806707414 22.826066369589874 -6.925342866050961 0.7840853332752553 1.0078577250933363 0.4457603145843473 0.9955408362624989 0.014346063081236381 0.0951294629254734 0.0900654418588692 0.012724323516623079 0.040301087117721845 1.1875643010540248e-07 6.925342866050961 -0.562097410508989 NSDEADLVPAK(ub)EANVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSDEADLVPAKEANVK 16 1 P83916;J3KS05;B5MD17 P83916 CBX1 Chromobox protein homolog 1 1 6059400.0 2427900.0 3631500.0 0.0 True False 3183000.411817048 3089694.3554761275 0.0 1.0 0.9706861312381496 0.0 21.60195591295411 -7.047185168177851 1.0547891855340148 1.0134056858584144 3.0479432422541115e-19 0.9876811183204615 0.05157163971131949 0.08544793719597515 0.18323276357692814 0.041002645183447886 0.07352572080549523 8.97046243395705e-08 7.047185168177851 -1.0134056858584144 down NSDEADLVPAK(ub)EANVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSDEADLVPAKEANVK 16 1 P83916;J3KS05;B5MD17 P83916 CBX1 Chromobox protein homolog 1 1 13252200.0 6323000.0 3947500.0 2981700.0 True False 9592453.273219028 3243037.7830417296 2392365.6880744617 1.0 0.3380822080307547 0.24940081748989676 23.19346840150988 -13.999999999999998 0.28328403912882705 6.493434502439464 0.2235568321723535 0.9996124665870759 0.0065927183532634645 15.578729127231986 0.16865640012571953 49.6779422618445 0.03454176308826343 1.0000000000000041e-14 13.999999999999998 -6.26987767026711 NSDEADLVPAK(ub)EANVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSDEADLVPAKEANVK 16 1 P83916;J3KS05;B5MD17 P83916 CBX1 Chromobox protein homolog 1 1 4135100.0 2427900.0 1707200.0 0.0 True False 3325560.241530457 1631770.259044553 0.0 1.0 0.4906752969519492 0.0 21.665165974477002 -7.957889133341747 0.5872559724247013 1.0120705161704082 9.29975767257754e-19 0.9892312090360484 0.04236751748920002 0.11191776635147849 0.16287819412785207 0.045381158667776283 0.07669466856233371 1.1018205462978068e-08 7.957889133341747 -1.0120705161704082 NSDEADLVPAK(ub)EANVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSDEADLVPAKEANVK 16 1 P83916;J3KS05;B5MD17 P83916 CBX1 Chromobox protein homolog 1 1 14101800.0 6323000.0 5478200.0 2300600.0 True False 8185248.1449636435 5173333.354275171 1881914.4061494246 1.0 0.6320313401198846 0.22991537615232355 22.96459472360233 -7.480889553147865 0.3555239373274348 1.0548372774023176 3.858610173754909e-13 0.9994004240506196 0.007700644614029064 0.11998669644108337 0.03869396281322326 0.019244668209563144 0.06434856061835573 3.304535690811242e-08 7.480889553147865 -1.0548372774019317 down NSDIEQSSDSK(ub)VK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSDIEQSSDSKVK 13 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;H7BZ48;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RGPD6;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 1 2001090.0 0.0 825590.0 1175500.0 True False 0.0 678257.0141358876 943161.9097600465 0.0 NSDIEQSSDSK(ub)VK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSDIEQSSDSKVK 13 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;H7BZ48;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RGPD6;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 1 1775050.0 0.0 1206700.0 568350.0 True False 0.0 1139546.0842254492 464916.13176346495 0.0 NSDLYGAK(ub)GAGIEIYPGSQCTLSDNGIHHCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSDLYGAKGAGIEIYPGSQCTLSDNGIHHCK 31 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 95111400.0 2926200.0 9205200.0 82980000.0 True False 4439259.3338752985 7562460.139444133 66578966.62857397 1.0 1.703540967236623 14.997764631707865 22.081887560205544 -6.917852554054694 0.8405157572683268 0.6833579973246653 17.03904133584884 0.9935629779972004 0.5166231773450537 0.0994516703390134 0.11228854887235697 0.4401344374105232 1.2924911207459153 1.2082239657771774e-07 6.917852554054694 16.355683338524173 up NSDLYGAK(ub)GAGIEIYPGSQCTLSDNGIHHCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSDLYGAKGAGIEIYPGSQCTLSDNGIHHCK 31 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 115388200.0 2926200.0 7228000.0 105234000.0 True False 3788023.5840254 6825755.446077364 86082491.79202324 1.0 1.8019305568377353 22.72490914656513 21.853013882297994 -6.914994842079142 0.8610392672840655 0.4499704536861456 25.738814025261092 0.9926736894549884 0.8608632043259444 0.10120661072608851 0.1215405244340056 0.7226934529673069 2.0712164094181804 1.2162004448280298e-07 6.914994842079142 25.288843571574947 up NSEFEGGK(ub)STVNCSTTPVAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSEFEGGKSTVNCSTTPVAER 21 1 Q99567;J3KMX1;I3L245 Q99567 NUP88 Nuclear pore complex protein Nup88 1 33096100.0 2363600.0 5772500.0 24960000.0 True False 3585754.00230595 4742352.274251649 20026645.059643388 1.0 1.3225537142821027 5.58505827414946 21.77384508602271 -6.922049397074081 0.8093772501458352 0.9127152670627761 6.305917172549801 0.9947315818020633 0.15166718676184826 0.09698106101778713 0.09947418390148573 0.13211518199232142 0.40384811421244277 1.196604420623491e-07 6.922049397074081 5.393201905487025 up NSEFEGGK(ub)STVNCSTTPVAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSEFEGGKSTVNCSTTPVAER 21 1 Q99567;J3KMX1;I3L245 Q99567 NUP88 Nuclear pore complex protein Nup88 1 29059700.0 2363600.0 5377100.0 21319000.0 True False 3059726.793521444 5077859.658149215 17439160.751412503 1.0 1.6595794333340133 5.699581017605088 21.54497140811516 -6.935399328903323 0.7010539673215106 0.949100692975634 6.6558629782800685 0.9974971144541922 0.10393314147642872 0.08992946877493503 0.06464485038013536 0.09793976217958654 0.35532750194922863 1.16038116569988e-07 6.935399328903323 5.706762285304435 NSEK(ub)EQDSEVSEDTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSEKEQDSEVSEDTK 15 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 2881950.0 1061300.0 1226000.0 594650.0 True False 1453691.290554089 1171831.2661601575 454205.91720117757 1.0 0.8061073721598087 0.3124500505386205 20.471289496852894 -6.955070111646302 0.5001048647000723 1.009877449833071 0.0873846683550811 0.9995413942720499 0.006198531544635239 0.08151163208733338 0.028015290707480222 0.007267844725109508 0.040722342534264176 1.1089957667165134e-07 6.955070111646302 -0.9224927814779899 down NSEK(ub)EQDSEVSEDTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSEKEQDSEVSEDTK 15 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 3449720.0 1529300.0 1657100.0 263320.0 True False 1271680.7094771962 1648172.8733914034 318378.99454588053 1.0 1.2960587206430045 0.2503607958925241 20.278305057024227 -6.831068766764364 1.3230154634814373 1.1580882357043645 0.22158196622307894 0.9080049826887189 0.13348156295441804 0.1795049683398528 0.6140981479593235 0.07920435826917163 0.18227841073694792 1.4754728864443268e-07 6.831068766764364 -0.9365062694812856 down NSEPEEVIPSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSEPEEVIPSR 11 0 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 0 5883400.0 1259800.0 1496700.0 3126900.0 False True 1219808.3385796563 2094340.1151873907 2307871.0850107507 1.0 1.716941956329007 1.8919948421553123 20.218223052601967 -11.06272731522701 0.26599929744793993 1.970106163828796e-10 1.9642168144430219 0.999234839963786 0.010674719973583548 3.0524122223136168 0.1405301363769541 1.9263927013254023 0.07372162268207107 8.655111852755144e-12 11.06272731522701 1.9642168142460112 NSGLVSITSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSGLVSITSR 10 0 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 0 9494000.0 1921800.0 2919300.0 4652900.0 False True 2519498.4107376738 2483751.819342273 4171462.5417683944 1.0 0.985812020661313 1.655671828960213 21.264705115601437 -6.902065584400821 0.9481523976153396 0.9737054244244675 1.7290012841902944 0.9875650305100588 0.0348458307176643 0.10990022643761944 0.16898459933114385 0.02745375666039597 0.07219657046932101 1.2529519477898018e-07 6.902065584400821 0.7552958597658269 NSGLVSITSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSGLVSITSR 10 0 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 0 6861900.0 1921800.0 1746500.0 3193600.0 False True 2632341.394692214 1669333.8550968303 2439337.4542565867 1.0 0.6341631288642242 0.9266797457104935 21.32791517712433 -9.895159335049279 6.3064011786477705 1.0000000236603666 0.7804214372873308 0.4289979378358041 0.11941940875986248 3.961314888165443e-08 7.103502037811514e-09 0.11562735739603563 0.038542448445058886 1.2730359407087915e-10 9.895159335049279 -0.21957858637303573 NSGSNSSSASSGSSK(ub)GQQPPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSGSNSSSASSGSSKGQQPPR 21 1 Q8N5U6;Q8N5U6-2;F5H510;F5H5Z1 Q8N5U6 RNF10 RING finger protein 10 1 4313900.0 1009200.0 1226700.0 2078000.0 True False 1323070.9731067037 1043681.1416391496 1862988.4935835158 1.0 0.7888323172780983 1.4080790308693958 20.3354590230819 -6.814685715937239 1.3947815988552585 0.8855341877320267 1.4201089022694575 0.8716939856387779 0.09206824727691425 0.2004859664883374 0.7677761187127818 0.051890274405540816 0.11979671250586249 1.5321958583176067e-07 6.814685715937239 0.5345747145374308 NSGSNSSSASSGSSK(ub)GQQPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSGSNSSSASSGSSKGQQPPR 21 1 Q8N5U6;Q8N5U6-2;F5H510;F5H5Z1 Q8N5U6 RNF10 RING finger protein 10 1 4927200.0 1009200.0 1389900.0 2528100.0 True False 1382328.51260453 1328489.6222153357 1931014.8478538608 1.0 0.961052029312661 1.3969290441788813 20.39866908460479 -6.8850957535098 1.050927883359003 0.9737531817009625 1.4310095470243225 0.9775703462779648 0.029494365483967118 0.12321384425218396 0.24579877520759272 0.02150950278421211 0.052760637269696105 1.3028794871257714e-07 6.8850957535098 0.45725636532336 NSHSLYLAGIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSHSLYLAGIFR 12 0 Q9UBF2 Q9UBF2 COPG2 Coatomer subunit gamma-2 0 4225200.0 1052800.0 1677500.0 1494900.0 False True 1380230.9953297016 1427223.5388437847 1340222.0880933555 1.0 1.0340468687292868 0.971012890326529 20.396478305840837 -6.7600219540292485 1.6125538013383725 1.0197759500357675 0.9707836839694474 0.6909948375389252 0.014320158340085053 0.28288000864611723 1.4497941809426125 0.007006939889303164 0.01683730683612264 1.7377129833644487e-07 6.7600219540292485 -0.04899226606632012 NSHSLYLAGIFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSHSLYLAGIFR 12 0 Q9UBF2 Q9UBF2 COPG2 Coatomer subunit gamma-2 0 4746700.0 1052800.0 1388400.0 2305500.0 False True 1442048.610850224 1327055.8971751751 1760988.3832629512 1.0 0.9202573943694937 1.2211713044990085 20.45968836736373 -6.836239368794338 1.2997970678074173 0.9575375927170532 1.2303510325075084 0.9177832958242768 0.036498455100442785 0.17323826830069738 0.5701614684511543 0.022031506655874306 0.050715176459051846 1.4580104315126226e-07 6.836239368794338 0.27281343979045525 NSIILTYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSIILTYR 8 0 Q9P2I0 Q9P2I0 CPSF2 Cleavage and polyadenylation specificity factor subunit 2 0 26952700.0 10384000.0 5937700.0 10631000.0 False True 13613524.55879903 5051818.304973321 9531006.099752812 1.0 0.3710881985891086 0.700113042628075 23.698537294992096 -10.605168930107814 6.642900305399061 1.001106797567336 0.5356006206086819 0.7264937435489075 0.13432383009904722 0.00220642875291427 0.00013114230839330248 0.13033101135593092 0.04335282974770036 2.4821674140694092e-11 10.605168930107814 -0.46550617695865415 NSIILTYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSIILTYR 8 0 Q9P2I0 Q9P2I0 CPSF2 Cleavage and polyadenylation specificity factor subunit 2 0 14996000.0 4539600.0 2248700.0 8207700.0 False True 4395492.882851409 3146617.6368155833 6057857.144277964 1.0 0.7158736734830827 1.378197464023229 22.06759351848716 -6.790128749936774 1.495729719925875 0.8412249462089981 1.3852744850363932 0.8017492967585674 0.12079734417632142 0.23517031342447686 1.039361641990603 0.06356670164022694 0.14881695368516695 1.621329370552829e-07 6.790128749936774 0.544049538827395 NSIILTYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSIILTYR 8 0 Q9P2I0 Q9P2I0 CPSF2 Cleavage and polyadenylation specificity factor subunit 2 0 19832800.0 10384000.0 4296900.0 5151900.0 False True 14223245.41704856 4107048.7500518584 3935127.3267110907 1.0 0.28875609114703055 0.27666873567366607 23.761747356514988 NSIILTYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSIILTYR 8 0 Q9P2I0 Q9P2I0 CPSF2 Cleavage and polyadenylation specificity factor subunit 2 0 10147300.0 4539600.0 2438000.0 3169700.0 False True 3774878.538378788 2424866.0100948876 3832469.6149630803 1.0 0.6423692803467802 1.0152564052058284 21.847998793921438 -10.980918435953564 12.01287010508161 1.1009826654342656 0.8288128427763229 0.21936776101747202 0.15223053125969147 0.07493212194629352 0.0001190240878015879 0.026826157999132374 0.04913219269609108 1.0449164446260098e-11 10.980918435953564 -0.27216982265794265 NSIILTYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSIILTYR 8 0 Q9P2I0 Q9P2I0 CPSF2 Cleavage and polyadenylation specificity factor subunit 2 0 23180200.0 3896700.0 12591000.0 6692500.0 False True 5044354.965440432 11890299.781621475 5474533.6708489265 1.0 2.3571496976488673 1.085279229625137 22.266238369348354 -6.630828569830045 2.0771456435727025 1.8935530725017609 1.090379558019919 0.12059265273428177 0.5820188864677154 0.5568447378144296 4.579400740582033 0.2290716671673641 0.644832717736694 2.3397606360910837e-07 6.630828569830045 -0.8031735144818419 NSILAQVLDQSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSILAQVLDQSAR 13 0 O14737;O14737-2;K7EQA1;K7ESJ4 O14737 PDCD5 Programmed cell death protein 5 0 15918600.0 2522600.0 7550800.0 5845200.0 False True 3307153.0288931495 6424250.072787875 5240394.775117588 1.0 1.942531844357371 1.584563740877592 21.65715837291711 -10.222097253990317 4.664110051500584 0.9998202746258079 1.7635477926214072 0.8584828433518081 0.146139866299693 0.00027318197229544023 4.556279637806626e-05 0.14153208090589606 0.047166439031067806 5.996567767257521e-11 10.222097253990317 0.7637275179955992 NSILAQVLDQSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSILAQVLDQSAR 13 0 O14737;O14737-2;K7EQA1;K7ESJ4 O14737 PDCD5 Programmed cell death protein 5 0 19932100.0 8139100.0 5451500.0 6341500.0 False True 7880728.725618094 7628312.379196933 4680470.909077901 1.0 0.96797043075463 0.5939134656244378 22.909897610202027 -6.9237898531593105 0.7961183835445608 1.0071815142276506 0.5280029484834122 0.9951704236066479 0.012811147089743825 0.09599305407996156 0.0944344781418824 0.011265727122914283 0.03507210468585172 1.1918185668625444e-07 6.9237898531593105 -0.47917856574423834 NSILAQVLDQSAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSILAQVLDQSAR 13 0 O14737;O14737-2;K7EQA1;K7ESJ4 O14737 PDCD5 Programmed cell death protein 5 0 16470400.0 2522600.0 6968000.0 6979800.0 False True 3455273.390701727 6660130.719905357 5331314.993493278 1.0 1.9275264116084196 1.5429502649023519 21.72036843444 -10.15748435922502 4.462451482798903 0.9998733180433269 1.7352383382771692 0.8297403057307794 0.15700255451816592 109909357.67584056 35.80587842103104 144399.78248114395 0.05374615042395026 6.958500147415998e-11 10.15748435922502 0.7353650202338423 NSILAQVLDQSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSILAQVLDQSAR 13 0 O14737;O14737-2;K7EQA1;K7ESJ4 O14737 PDCD5 Programmed cell death protein 5 0 11978500.0 8139100.0 2265900.0 1573500.0 False True 6768022.273266101 2253693.146954064 1902511.5749580085 1.0 0.3329913903883298 0.28110303100995815 22.690302885636303 -13.999999999999998 0.3621095946380729 9.842859623751208 0.2750426615229081 0.9997770870999281 0.004887378077235698 21.92617732289087 0.19464697817752383 149.98082165932684 0.014870571662207314 1.0000000000000041e-14 13.999999999999998 -9.5678169622283 NSK(ub)ITEDFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSKITEDFR 9 1 O95864;O95864-4;O95864-2;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 91814000.0 47422000.0 27969000.0 16423000.0 True False 62170701.23530126 23796134.222308114 14723705.500539973 1.0 0.38275479847405014 0.23682707783549461 25.889731515613615 -13.999999999999975 0.20259262184212573 4.465545617164992 0.14443966833502717 0.9994872247156448 0.007490286264357394 12.58335129940302 0.1427083989969534 17.29920145564685 0.09115439593767845 1.0000000000000573e-14 13.999999999999975 -4.321105948829964 NSK(ub)ITEDFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSKITEDFR 9 1 O95864;O95864-4;O95864-2;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 120531000.0 40029000.0 38177000.0 42325000.0 True False 38758301.305766866 53421275.1904249 31238812.77721706 1.0 1.3783182799726137 0.8059902453095648 25.208002006082957 -6.728481544849895 1.7291254473266573 1.2280572008188482 0.8064460220356175 0.5520819613288044 0.15905534937212462 0.33907744076718765 1.9854904859717784 0.07292210914258522 0.18123839670190242 1.8686090812773337e-07 6.728481544849895 -0.4216111787832306 NSK(ub)ITEDFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSKITEDFR 9 1 O95864;O95864-4;O95864-2;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 261475400.0 24110400.0 77045000.0 160320000.0 True False 36577239.50634516 63295717.794667505 128632681.72924784 1.0 1.7304673247331148 3.5167411063629763 25.12444286284151 -6.955933736773802 0.48939349729903203 0.9606930094839492 4.362182833076165 0.9995883777192509 0.02144822580420892 0.08118705034393563 0.02675225425417197 0.025685063885706048 0.14732650407620976 1.1067926418829868e-07 6.955933736773802 3.401489823592216 NSK(ub)ITEDFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSKITEDFR 9 1 O95864;O95864-4;O95864-2;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 97639000.0 47422000.0 21622000.0 28595000.0 True False 64955194.931363404 20666668.545607623 21841449.93251102 1.0 0.31816806288466376 0.336254089539572 25.952941577136507 -10.060035260136944 7.689415625931999 1.0000000398198203 0.32721107628520496 0.999458304937398 0.0073835894631501834 5.029993677943532e-09 6.372910598777921e-10 0.007149130076090698 0.002383043252167763 8.708928797580646e-11 10.060035260136944 -0.6727889635346154 NSK(ub)ITEDFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSKITEDFR 9 1 O95864;O95864-4;O95864-2;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 129001000.0 40029000.0 53133000.0 35839000.0 True False 33285887.08537419 52846761.982925236 43332769.19918665 1.0 1.5876627186585057 1.3018360931178865 24.988407281517233 -10.089891731536495 4.619024813531575 0.9999739905585537 1.4447494058506072 0.7634942738761163 0.11668823129102239 81143800.96591926 2.2272206443625278 24006.18136806624 0.03994548528913577 8.130331779183352e-11 10.089891731536495 0.44477541529205344 NSK(ub)ITEDFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSKITEDFR 9 1 O95864;O95864-4;O95864-2;O95864-3 O95864 FADS2 Fatty acid desaturase 2 1 261264400.0 24110400.0 66652000.0 170502000.0 True False 31211388.08703649 62942757.6081832 139472385.4982567 1.0 2.0166599906630296 4.468637700743145 24.895569184933958 -6.956227339548591 0.4857007320892158 0.9441895404687085 5.6443268857011235 0.9996036498316365 0.02898518180337762 0.08107748345667873 0.02632888461038684 0.034981781044295626 0.2022381705460665 1.1060446527049338e-07 6.956227339548591 4.700137345232415 NSK(ub)LLSTSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSKLLSTSAK 10 1 C9J2P0;P51965;P51965-3 C9J2P0 UBE2E1 Ubiquitin-conjugating enzyme E2 E1 1 5038990.0 1811400.0 2543500.0 684090.0 True False 1753898.098510231 3559132.8141772705 504906.30673990346 1.0 2.0292700112967874 0.28787664868829793 20.74213349895141 -6.746565395665689 1.662633500286478 1.6077164861841398 0.28531966012593174 0.6340186207415517 0.4324524872221784 0.306079362717912 1.6636261073554277 0.20556825277029858 0.5008619907709305 1.7923986342977905e-07 6.746565395665689 -1.322396826058208 NSK(ub)LTYLLQNSLGGSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSKLTYLLQNSLGGSAK 17 1 Q9BW19;A0A087X1W5 Q9BW19 KIFC1 Kinesin-like protein KIFC1;Kinesin-like protein 1 10416000.0 2416400.0 5359600.0 2640000.0 True False 3309808.3807546366 5122795.150172905 2016486.3725066977 1.0 1.547761852305452 0.6092456542897926 21.658316264865046 -6.748521314286924 1.6555757699090767 1.3226629154739467 0.6076171919964228 0.6424946359712094 0.2301567989050131 0.30262288614224564 1.631561884363698 0.10984708884595583 0.26706736614449195 1.7843444144087872e-07 6.748521314286924 -0.7150457234775238 NSK(ub)LTYLLQNSLGGSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSKLTYLLQNSLGGSAK 17 1 Q9BW19;A0A087X1W5 Q9BW19 KIFC1 Kinesin-like protein KIFC1;Kinesin-like protein 1 8778800.0 0.0 6117000.0 2661800.0 True False 0.0 6084046.506870571 3218370.0732273445 0.0 NSK(ub)MLQK(ub)VVLPSYEEALSLPSK(ub)TPEGGPAPPPYSEV ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSKMLQKVVLPSYEEALSLPSKTPEGGPAPPPYSEV 36 3 Q13571 Q13571 LAPTM5 Lysosomal-associated transmembrane protein 5 3 22967300.0 6560000.0 11462000.0 4945300.0 True False 5454930.657274835 11400251.930971134 5979339.365516272 1.0 2.0898985976599844 1.0961348074227255 22.379129426543713 -6.6241179788570195 2.101289373416227 1.721059875584748 1.0999825284866425 0.0969452570472622 0.4681989428569059 0.5744369244834339 4.825134083249057 0.18270714111789926 0.5190557878909863 2.3761946905444544e-07 6.6241179788570195 -0.6210773470981055 NSK(ub)NQGIEEALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSKNQGIEEALK 12 1 P18206;P18206-2;P18206-3 P18206 VCL Vinculin 1 19959200.0 8787000.0 7830300.0 3341900.0 True False 11519842.093429055 6662049.76227034 2996112.245768401 1.0 0.5783108577564955 0.2600827529986188 23.457617605593484 -7.965003602514971 0.2638194852730856 1.1574108638569645 8.103038709240386e-15 0.9995398491238203 0.006500819348582026 0.10443276823220686 0.04732506995051119 0.06146627829321657 0.0927191482622263 1.0839179227793113e-08 7.965003602514971 -1.1574108638569565 down NSK(ub)NQGIEEALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSKNQGIEEALK 12 1 P18206;P18206-2;P18206-3 P18206 VCL Vinculin 1 21096500.0 7686200.0 7950600.0 5459700.0 True False 7442205.788213173 11125316.041831262 4029640.782510862 1.0 1.494894975821729 0.5414578549941379 22.827298853032936 -6.765605599085992 1.5910202649306224 1.2854405726395266 0.5369291481193258 0.7135938904065988 0.2083592432442749 0.273579710833959 1.3659593748863499 0.10326377008950723 0.2468402406684206 1.7155145305343793e-07 6.765605599085992 -0.7485114245202008 NSK(ub)NQGIEEALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSKNQGIEEALK 12 1 P18206;P18206-2;P18206-3 P18206 VCL Vinculin 1 41617900.0 21412000.0 12629000.0 7576900.0 True False 32483569.42688059 10375256.27917264 6079322.3939267555 1.0 0.3194001294262624 0.18715068883089045 24.953206834650878 -13.999999999999998 0.23034274001211227 5.3032517580359055 0.12305921279725558 0.9995102639418286 0.007881054487425161 13.301978596703703 0.15196134188419494 26.184733401031018 0.06850323349364884 1.0000000000000041e-14 13.999999999999998 -5.18019254523865 NSK(ub)NQGIEEALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSKNQGIEEALK 12 1 P18206;P18206-2;P18206-3 P18206 VCL Vinculin 1 22797900.0 8787000.0 8723400.0 5287500.0 True False 12035791.359746335 8337971.3435738385 4038701.3994807447 1.0 0.6927646960930344 0.3355576113580839 23.520827667116375 -7.114975202519926 0.29903652359908667 1.068712890462324 5.740588541177039e-11 0.9999528080369462 0.0018651882904003943 0.07799384370732097 0.012894433029893607 0.00746490462848531 0.03379843265564603 7.674053056553623e-08 7.114975202519926 -1.0687128904049181 down NSK(ub)NQGIEEALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSKNQGIEEALK 12 1 P18206;P18206-2;P18206-3 P18206 VCL Vinculin 1 24292400.0 7686200.0 12888000.0 3718200.0 True False 6391415.8563941885 12818569.785932291 4495658.42898562 1.0 2.0055915737524983 0.7033900672396416 22.607704128467212 -6.700506486255147 1.82931194165532 1.624123299109698 0.7072557722212246 0.41991587448836887 0.4244328357819837 0.3944442857192431 2.566605622900414 0.1850852388784862 0.4756490944422345 1.9929367411244857e-07 6.700506486255147 -0.9168675268884735 NSK(ub)QQLSAEELDAQLDAYNAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSKQQLSAEELDAQLDAYNAR 21 1 Q86V81;E9PB61 Q86V81 ALYREF THO complex subunit 4 1 14139400.0 3212800.0 7617500.0 3309100.0 True False 4212011.912799459 6480998.692782441 2966706.07512859 1.0 1.5386942931210585 0.7043441795863316 22.00607808605637 -6.732395715477205 1.714626626335114 1.3233134323837683 0.7046286982230234 0.5703178420434389 0.2264137428050463 0.33174506882371835 1.9118146812671044 0.10460053513561592 0.2588450820345782 1.8518435128700867e-07 6.732395715477205 -0.6186847341607449 NSK(ub)QQLSAEELDAQLDAYNAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSKQQLSAEELDAQLDAYNAR 21 1 Q86V81;E9PB61 Q86V81 ALYREF THO complex subunit 4 1 25898300.0 8764800.0 8632500.0 8501000.0 True False 8486566.22160895 12079502.267892802 6274333.075466571 1.0 1.4233674671783418 0.7393252950163198 23.016749507422006 -6.739318747780119 1.6893935260547404 1.2521077280263373 0.739001453009735 0.6017581543712834 0.17788408765779343 0.31906811946934516 1.787816171120849 0.0833107790962429 0.20457421123025593 1.8225575563406287e-07 6.739318747780119 -0.5131062750166023 NSK(ub)QQLSAEELDAQLDAYNAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSKQQLSAEELDAQLDAYNAR 21 1 Q86V81;E9PB61 Q86V81 ALYREF THO complex subunit 4 1 13198400.0 3212800.0 6210200.0 3775400.0 True False 4400658.9826554 5935812.82961486 2883728.276803711 1.0 1.3488463552868013 0.65529464749928 22.06928814757926 -6.769929111172312 1.5745275001869725 1.200102199539318 0.6513844083989929 0.7303872095097459 0.14701987396223093 0.2665295032048742 1.303994852751915 0.07359757775278393 0.1752182770144863 1.6985208752504304e-07 6.769929111172312 -0.548717791140325 NSK(ub)QQLSAEELDAQLDAYNAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSKQQLSAEELDAQLDAYNAR 21 1 Q86V81;E9PB61 Q86V81 ALYREF THO complex subunit 4 1 23750000.0 8764800.0 11722000.0 3263200.0 True False 7288319.546475981 11658851.259365177 3945520.032667928 1.0 1.5996624715778849 0.5413483873076956 22.797154782856282 -6.75297769387092 1.6386899793138148 1.351340404354222 0.5387413802847495 0.6617314218875815 0.2520292863773214 0.2948832092244265 1.5588111300905814 0.12144616733949741 0.2939382585758572 1.7661285298268643e-07 6.75297769387092 -0.8125990240694726 NSLEFFTVLAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSLEFFTVLAQR 12 0 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 3768610.0 782710.0 1266200.0 1719700.0 False True 1026140.3897744232 1077287.8956089432 1541761.940527222 1.0 1.0498445498727165 1.5024863614092296 19.96879669381266 -6.927816080864746 0.7644946713015575 0.9925308696163803 1.5904496475673153 0.99609166741748 0.0141314932032467 0.09378715294313869 0.0833489173022792 0.012711164248507633 0.04145875382828784 1.1808205948556025e-07 6.927816080864746 0.5979187779509351 NSLEFFTVLAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSLEFFTVLAQR 12 0 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 4426170.0 1670800.0 928970.0 1826400.0 False True 1617761.3685496806 1299912.5655145533 1348011.0491744652 1.0 0.8035255327427692 0.833257039870444 20.62556738487942 -10.536813422107931 9.297789607903214 1.0000089644847363 0.8183912863261482 0.9802949023879777 0.012137836957787397 2.255641497770132e-06 1.123623077059016e-07 0.011752989877831984 0.003917470033040953 2.9052705239448735e-11 10.536813422107931 -0.1816176781585881 NSLEFFTVLAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSLEFFTVLAQR 12 0 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 3545510.0 782710.0 1222100.0 1540700.0 False True 1072099.038942421 1168103.581055734 1176818.3917125282 1.0 1.0895482027556123 1.0976769393184125 20.03200675533555 -13.956564921603743 0.3397840403900766 1.1705392310192292e-10 1.0989642552415617 0.9997333265648001 0.0007226507609166177 19.088684334853195 0.18676491744920917 13.691217273914724 0.0025146427266359438 1.1051852456355212e-14 13.956564921603743 1.0989642551245078 NSLEFFTVLAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSLEFFTVLAQR 12 0 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 3562000.0 1670800.0 0.0 1891200.0 False True 1389344.2289900598 0.0 2286641.1760791824 1.0 0.0 1.6458420658941986 20.405972660313697 -6.742235717394193 1.6783519862238843 0.406539779766376 1.647309867100462 0.6149457402360841 0.42014527664617785 0.3138159250256462 1.7364975755285235 0.1979622550988465 0.4846243728771683 1.8103572375847738e-07 6.742235717394193 1.2407700873340861 NSLEILLGSIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSLEILLGSIGR 12 0 Q9UBI1;R4GNF2;H0Y4E5 Q9UBI1 COMMD3 COMM domain-containing protein 3 0 5352240.0 741640.0 1547000.0 3063600.0 False True 972297.2220519753 1316193.6301587713 2746608.0601263023 1.0 1.3536947348065267 2.824864658493778 19.891037873899123 -6.94397737210068 0.6214592009107196 0.9839135236953058 3.2727813433441706 0.9986398330142643 0.0291424774279607 0.08599804905610588 0.046691986331198435 0.02930974127750975 0.12457447749923041 1.1376865607794518e-07 6.94397737210068 2.288867819648865 up NSLEILLGSIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSLEILLGSIGR 12 0 Q9UBI1;R4GNF2;H0Y4E5 Q9UBI1 COMMD3 COMM domain-containing protein 3 0 6502300.0 3132400.0 1646300.0 1723600.0 False True 3032963.6765890755 2303676.1753410855 1272137.453108362 1.0 0.7595462461758989 0.41943708819455106 21.532296789370463 -6.966214998388956 0.33655227397107756 1.0383945927990668 0.12934480856551608 0.9999360401736372 0.0019047923250002127 0.07755108905150457 0.01341954999599976 0.004853451748384448 0.0295135720530265 1.0808987176602901e-07 6.966214998388956 -0.9090497842335507 down NSLEILLGSIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSLEILLGSIGR 12 0 Q9UBI1;R4GNF2;H0Y4E5 Q9UBI1 COMMD3 COMM domain-containing protein 3 0 8895500.0 2061300.0 3617700.0 3216500.0 False True 3127142.8012156277 2972093.169780886 2580757.3651579656 1.0 0.9504181160596603 0.8252764677566808 21.576413670870984 -6.95525708776099 0.4977974685925192 1.002554760155857 0.7677625384523198 0.9995518546271531 0.0015563731529308058 0.08144094515694178 0.027738762154055272 0.0018328739656334955 0.010322369102069951 1.1085184152915126e-07 6.95525708776099 -0.2347922217035373 NSLEILLGSIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSLEILLGSIGR 12 0 Q9UBI1;R4GNF2;H0Y4E5 Q9UBI1 COMMD3 COMM domain-containing protein 3 0 6381740.0 741640.0 3084200.0 2555900.0 False True 1015844.3500674011 2947929.8459144877 1952249.0604128302 1.0 2.901950329023234 1.9217993979917287 19.954247935422014 -10.025535451533944 5.773249140380423 0.999996658501443 2.41187486350781 0.7345080647983373 0.40014494199134193 1.7211329403254587e-05 2.90403235938869e-06 0.38743959126833033 0.12914622469996326 9.428976394203445e-11 10.025535451533944 1.4118782050063672 NSLEILLGSIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSLEILLGSIGR 12 0 Q9UBI1;R4GNF2;H0Y4E5 Q9UBI1 COMMD3 COMM domain-containing protein 3 0 5517040.0 3132400.0 821440.0 1563200.0 False True 2604729.3888487373 817014.7396769264 1890057.8925798319 1.0 0.31366588144422874 0.7256254337481167 21.31270206480474 -10.323638410599182 5.866876251779202 1.0000516930282628 0.5196456575968379 0.6444840180288273 0.1681817829683252 0.00011372778945752681 1.3111163455185793e-05 0.1628587549010887 0.0542804370476488 4.746369989869202e-11 10.323638410599182 -0.4804060354314249 NSLEILLGSIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSLEILLGSIGR 12 0 Q9UBI1;R4GNF2;H0Y4E5 Q9UBI1 COMMD3 COMM domain-containing protein 3 0 8177600.0 2061300.0 3242400.0 2873900.0 False True 2668393.4842975778 3061957.5897013335 2350879.6887041787 1.0 1.147491030734306 0.8810093798152934 21.347539992963434 -6.756459928435766 1.6255109859340928 1.086050981228135 0.8801950126002144 0.676355729004205 0.06200861264096482 0.28896101496969767 1.5039173782049242 0.030108456419687606 0.07261874500391992 1.7520240828356911e-07 6.756459928435766 -0.20585596862792055 NSLESYAFNMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 NSLESYAFNMK 11 0 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 178148400.0 28147400.0 70146000.0 79855000.0 False True 36901513.97980932 59680490.2269664 71592370.62324911 1.0 1.6172911024631837 1.9400930450284752 25.137176671997366 -9.958626891721822 0.1487550349547435 6.639431774696187e-16 2.431491263320427 0.999740942416538 0.006277436095392206 1.5189160981613696 0.06853737434234472 0.8830304543829842 0.28589194777072047 1.0999504159421885e-10 9.958626891721822 2.4314912633204266 NSLESYAFNMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 NSLESYAFNMK 11 0 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 132285400.0 41481900.0 17348500.0 73455000.0 False True 40165079.79054405 24275846.521232355 54214931.8972352 1.0 0.604401799967233 1.3498026688844988 25.259438406736614 -6.762509692995147 1.6029087688013997 0.7709336765299457 1.3528798884280182 0.7011714637468499 0.16645557417081533 0.2787219168378967 1.4119305881230306 0.08191179145982028 0.1963712561128369 1.727787417683221e-07 6.762509692995147 0.5819462118980725 NSLESYAFNMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSLESYAFNMK 11 0 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 288258800.0 9748300.0 270180000.0 8330500.0 False True 14788883.796191866 221964268.07402524 6683973.023612144 1.0 15.008858757222841 0.4519592631685473 23.818009832100305 -6.651213894307757 2.0045977567169966 9.999999997022096 0.5136171763199749 0.2175153003112531 5.959187867033683 0.4968786525199831 3.8286509638903827 2.4154009443308486 6.614134567153903 2.2324724373721602e-07 6.651213894307757 -9.48638282070212 NSLESYAFNMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NSLESYAFNMK 11 0 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 169680400.0 28147400.0 70444000.0 71089000.0 False True 38554254.43488374 67331551.15284353 54299242.32391244 1.0 1.7464104063162016 1.4083852254391591 25.200386733520258 -10.2181658652923 4.890519694164689 0.9999133277223311 1.5773978158786073 0.79551649242311 0.13799820223013637 0.0001304351734529377 2.085249464968304e-05 0.13363611308159165 0.044538728253179796 6.051097277454609e-11 10.2181658652923 0.5774844881562762 NSLESYAFNMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NSLESYAFNMK 11 0 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 65264400.0 41481900.0 14568800.0 9213700.0 False True 34494037.809757456 14490314.982719623 11140242.070664512 1.0 0.4200817272433294 0.3229613805175696 25.03984368217089 -13.999999999999998 0.25143029620240775 5.06231333952557 0.28443869507452735 0.9995453951736175 0.00637317305897982 14.055178686693948 0.15866770400133223 28.861697171954084 0.04446696562177772 1.0000000000000041e-14 13.999999999999998 -4.7778746444510425 NSLESYAFNMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NSLESYAFNMK 11 0 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 35234300.0 9748300.0 15005000.0 10481000.0 False True 12619366.517720887 14169958.559544941 8573565.54414158 1.0 1.122874000025803 0.6793974588266418 23.589136154192754 -6.832788468389407 1.3153000632960354 1.0655412731005884 0.6667607612933786 0.9113537534424984 0.05566183598823637 0.177396651031583 0.5992048793642585 0.033215965209200234 0.07644376208041863 1.469641921150221e-07 6.832788468389407 -0.39878051180720986 NSLESYAFNMK(ub)ATVEDEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSLESYAFNMKATVEDEK 18 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 25671600.0 8216600.0 8612100.0 8842900.0 True False 7955768.530539443 12050956.441508207 6526679.208686424 1.0 1.514744476947608 0.8203706761493577 22.923569871551546 -6.708154819704108 1.8014976098213669 1.3170532058937625 0.8220728620893037 0.456358139199309 0.21697555442517216 0.37885223701068743 2.395521589627675 0.09588181023354679 0.24415739809185066 1.9581464981514373e-07 6.708154819704108 -0.49498034380445877 NSLESYAFNMK(ub)ATVEDEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSLESYAFNMKATVEDEK 18 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 23207600.0 5693700.0 11960000.0 5553900.0 True False 8637759.165226515 9825644.556093482 4456169.23063916 1.0 1.1375224022972417 0.5158941277939997 23.042225661745807 -6.848680504785166 1.241419201982496 1.0733131307591255 0.49166626570633887 0.938366291473368 0.06618713210068262 0.15891451769712509 0.471944366666067 0.04173306204235355 0.09649624384679457 1.4168357129832722e-07 6.848680504785166 -0.5816468650527866 NSLESYAFNMK(ub)ATVEDEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSLESYAFNMKATVEDEK 18 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 19706100.0 8216600.0 6546700.0 4942800.0 True False 6832466.95709823 6511431.627681791 5976316.627074969 1.0 0.953013262788938 0.8746938206362186 22.703975146985822 -6.963447620417964 0.38379914562731143 1.005155206475692 0.8197656877159558 0.9998774139001176 0.0005722351625823084 0.07849219520169007 0.016744987949814542 0.0010156205135238906 0.006606117838149484 1.0878083285901956e-07 6.963447620417964 -0.18538951875973608 NSLGGDVLFVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSLGGDVLFVGK 12 0 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 0 4920800.0 1549400.0 3371400.0 0.0 False True 2031278.404410942 2868400.2616142733 0.0 1.0 1.4121157667927313 0.0 20.953956556440648 -6.855111426616016 1.394521721281141 1.218405589038413 3.314777092064555e-21 0.9021584894288821 0.1854609174474769 0.1698603349268488 0.663952486327956 0.10708618275325288 0.224794943761194 1.3960101418078595e-07 6.855111426616016 -1.218405589038413 down NSLSSIMK(ub)NK(ub)DK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSLSSIMKNKDK 12 2 Q8IY51 Q8IY51 TIGD4 Tigger transposable element-derived protein 4 2 8781200.0 1985600.0 3222800.0 3572800.0 True False 2603140.8285777536 2741970.802376011 3203120.928717602 1.0 1.0533317184664603 1.230483150797359 21.311821932235954 -6.949141726010862 0.5681951719533773 0.9977749662208713 1.2946261118583147 0.9991321415608793 0.002902232879107216 0.08383236228681668 0.03740395748836451 0.003081105770076215 0.014753703211414363 1.1242380345294e-07 6.949141726010862 0.2968511456374434 NSLSSIMK(ub)NK(ub)DK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSLSSIMKNKDK 12 2 Q8IY51 Q8IY51 TIGD4 Tigger transposable element-derived protein 4 2 11641200.0 4757500.0 1570700.0 5313000.0 True False 4606475.766623842 2197888.7010922926 3921365.913416523 1.0 0.4771301994069014 0.8512724503683982 22.135231992765377 -9.910625224993222 6.5863670379664825 1.0000000224417578 0.6642013248876442 0.5178507896806321 0.15274293434536837 5.047679238328307e-08 8.36490523437177e-09 0.1478927212614487 0.04929757008086679 1.2284989086517082e-10 9.910625224993222 -0.3357986975541136 NSLSSIMK(ub)NK(ub)DK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSLSSIMKNKDK 12 2 Q8IY51 Q8IY51 TIGD4 Tigger transposable element-derived protein 4 2 9992700.0 1985600.0 3315400.0 4691700.0 True False 2719729.9788223864 3168914.6654383237 3583617.088594573 1.0 1.1651578245316947 1.3176370876884773 21.375031993758846 -6.972082990437692 0.2023386655593307 0.9119348514677164 1.575080732053551 0.9999943941337444 0.0003070545091559529 0.07563240770261281 0.006552148317582844 0.004856524909304773 0.016093046508065933 1.0663923221361582e-07 6.972082990437692 0.6631458805858346 NSLSSIMK(ub)NK(ub)DK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSLSSIMKNKDK 12 2 Q8IY51 Q8IY51 TIGD4 Tigger transposable element-derived protein 4 2 9200700.0 4757500.0 1407300.0 3035900.0 True False 3956072.042985527 1399718.5955728197 3670692.6535843858 1.0 0.35381524410169607 0.9278629442789991 21.915637268199653 -10.52159262444981 9.021970167311967 1.0000173425113803 0.640839094190362 0.3429440344736351 0.23435399224209613 8.17537736694685e-05 4.3355014495800455e-06 0.2269232033705121 0.075637425755905 3.008897375810224e-11 10.52159262444981 -0.3591782483210183 NSMFTAGK(ub)GVAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSMFTAGKGVAEK 13 1 A0A0U1RR27;Q7Z401;Q7Z401-2 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 2892700.0 1348600.0 1544100.0 0.0 True False 1768027.6598609772 1313726.2988546581 0.0 1.0 0.7430462365944878 0.0 20.753709414433676 -7.346710573971213 0.7900584879994633 0.9894047992918262 8.421069839357821e-23 0.9878496894646055 0.04673915678313464 0.10857747579948292 0.13785544647622092 0.04011959503160044 0.07139903062556338 4.5007970071088205e-08 7.346710573971213 -0.9894047992918262 down NSMFTAGK(ub)GVAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSMFTAGKGVAEK 13 1 A0A0U1RR27;Q7Z401;Q7Z401-2 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 6389100.0 1442000.0 4095300.0 851800.0 True False 1199086.8914314515 4073237.8060466 1029907.4417217867 1.0 3.396949658238721 0.8589097663241895 20.19350477627909 -6.659103724686905 1.9757137372263633 2.544084745941706 0.869466842015394 0.23172282661593513 1.020800255941094 0.4867262008346524 3.6512358606101674 0.41752816892499794 1.1317413507144012 2.192281279500008e-07 6.659103724686905 -1.674617903926312 NSNICHYTFQDK(ub)QVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSNICHYTFQDKQVSR 16 1 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 1 23603300.0 9090800.0 10404000.0 4108500.0 True False 11918126.835432444 8851763.75447437 3683391.8315148526 1.0 0.7427143440157211 0.30905794865046865 23.50665417034811 -6.963247378790516 0.3869559879720482 1.0275537195486537 0.008712591927557177 0.9998723321945123 0.0032216015598645997 0.07856086416628445 0.0169890642329083 0.005609776893528475 0.03652648838347564 1.0883100037056008e-07 6.963247378790516 -1.0188411276210965 down NSNICHYTFQDK(ub)QVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSNICHYTFQDKQVSR 16 1 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 1 23917100.0 13104000.0 8205900.0 2607200.0 True False 12688020.692766966 11482558.663203197 1924296.1056765607 1.0 0.9049921135255584 0.15166243437587867 23.596963693245 -6.935505788511364 0.7485898898348704 1.0110432042265312 1.5193587316925008e-18 0.996598980986311 0.02213200356155559 0.09121382336505833 0.07724817294404124 0.020211865868780408 0.06699382455605969 1.1600967536490495e-07 6.935505788511364 -1.0110432042265312 down NSNICHYTFQDK(ub)QVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSNICHYTFQDKQVSR 16 1 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 1 74949900.0 19644000.0 8089900.0 47216000.0 True False 29801384.168767132 6646194.13832281 37883736.90449202 1.0 0.2230162901389073 1.2712072932570517 24.828876004531192 -6.708188579600556 1.8018449393373568 0.521442446712819 1.2685965051444381 0.45642344434804116 0.3275109859796311 0.37872192701535334 2.395746886270393 0.14471455216157336 0.368427592159275 1.9579942874823615e-07 6.708188579600556 0.7471540584316191 NSNICHYTFQDK(ub)QVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSNICHYTFQDKQVSR 16 1 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 1 22598100.0 9090800.0 9185200.0 4322100.0 True False 12451914.42963264 8779367.492605457 3301308.996443641 1.0 0.7050616627843682 0.26512461317492664 23.569864231871 -7.141460512266863 0.3895495196726781 1.0308372221692712 6.108135667463449e-11 0.9998032761263485 0.004235123051828231 0.08082846470655074 0.02082662412583684 0.007424245195378875 0.039190644720571675 7.220038073299893e-08 7.141460512266863 -1.0308372221081898 down NSNICHYTFQDK(ub)QVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSNICHYTFQDKQVSR 16 1 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 1 24144200.0 13104000.0 7078000.0 3962200.0 True False 10896556.605629502 7039869.409126995 4790677.700857084 1.0 0.6460636753348281 0.439650604704065 23.377368968679278 -9.633428497305045 0.12277359597918351 1.6791480129177305 1.7787235232419746e-16 0.9998848631592637 0.0024828420629826194 1.1094504660455489 0.050727950603207124 0.46952748465840477 0.22060662775986983 2.325795375721172e-10 9.633428497305045 -1.6791480129177303 NSNICHYTFQDK(ub)QVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSNICHYTFQDKQVSR 16 1 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 1 58819900.0 19644000.0 7542900.0 31633000.0 True False 25429545.241130125 7123130.984258003 25876118.5819894 1.0 0.2801124014100317 1.0175612004314172 24.600002326623642 -10.939237672300328 12.94227662628873 1.057425679557266 0.6488368009696941 0.23215028125176929 0.30106221150510953 0.14790368507749513 0.0006943875883425254 0.08642626157104692 0.09716741094430534 1.1501707734205388e-11 10.939237672300328 -0.408588878587572 NSNILEDLETLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSNILEDLETLR 12 0 P48444;B0YIW6;Q6P1Q5 P48444 ARCN1 Coatomer subunit delta 0 628390.0 0.0 628390.0 0.0 False True 0.0 879309.4040105594 0.0 0.0 NSNIQAK(ub)GVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSNIQAKGVR 10 1 I3L3Z1;Q8NEM2 I3L3Z1;Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 2379360.0 502360.0 638100.0 1238900.0 True False 658598.8248611602 542897.9672943183 1110710.5123679575 1.0 0.8243227087578953 1.6864750899033372 19.329040412169512 -6.853625056555109 1.217355224288086 0.9058691382168995 1.7234497683397043 0.9454277790312999 0.08690044569443497 0.15351688199174068 0.4359597295780837 0.05579937088185771 0.12946791088139023 1.400796162898241e-07 6.853625056555109 0.8175806301228048 NSNLVGAAHEELQQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSNLVGAAHEELQQSR 16 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 20904850.0 2056100.0 2547050.0 16301700.0 False True 1990830.2309522377 3564100.3476902843 12031795.729482796 1.0 1.7902583014250957 6.0436071054274905 20.924938769083717 -6.938176074252605 0.6763175780162007 0.9504162971688 7.131571865905662 0.9979151322784017 0.10113473780406836 0.08860862721817432 0.05847300538981494 0.09713647541197214 0.3691156456022434 1.1529857127229184e-07 6.938176074252605 6.181155568736862 NSNMGFWDDAVK(ub)EVGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSNMGFWDDAVKEVGPR 17 1 I1E4Y6;Q6Y7W6-4;Q6Y7W6-5;Q6Y7W6;Q6Y7W6-3;C9JH18 I1E4Y6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 14532200.0 6632400.0 4151000.0 3748800.0 True False 6421858.092392206 5808515.947179031 2766876.818410663 1.0 0.9044914826224851 0.4308529990235231 22.614559354651945 -6.939988726569383 0.6596701462460343 1.0053174434570649 0.3031708753817718 0.9981623992245617 0.010667959472935256 0.08777182605350764 0.05463346429200896 0.010383554758017574 0.040767156326240374 1.1481834256936342e-07 6.939988726569383 -0.7021465680752931 down NSNMGFWDDAVK(ub)EVGPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSNMGFWDDAVKEVGPR 17 1 I1E4Y6;Q6Y7W6-4;Q6Y7W6-5;Q6Y7W6;Q6Y7W6-3;C9JH18 I1E4Y6 GIGYF2 PERQ amino acid-rich with GYF domain-containing protein 2 1 14578700.0 6632400.0 6086900.0 1859400.0 True False 5515134.465138658 6054108.66154494 2248191.9431057684 1.0 1.097726392676943 0.40764045868993076 22.39496463008622 -6.871026774270967 1.1287196758914828 1.0556231320953082 0.36644137107607816 0.9656937301520846 0.05647284960760748 0.1358705460607581 0.32290671969526596 0.03880622324691917 0.09203790309107152 1.3457773842726203e-07 6.871026774270967 -0.6891817610192301 down NSNPALNDNLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSNPALNDNLEK 12 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 31673600.0 7647500.0 2099100.0 21927000.0 False True 7404734.298529866 2937281.576661893 16183660.904100157 1.0 0.39667616125605754 2.1855829327074243 22.820016538049558 -6.815727733826481 1.390170294860517 0.6733321090410934 2.221195097136358 0.8742797692429143 0.26348174002264474 0.19910139873200744 0.7571741755636814 0.1489771820364221 0.3438347961780069 1.5285240141382215e-07 6.815727733826481 1.5478629880952646 up NSNPALNDNLEK(ub)GLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSNPALNDNLEKGLLK 16 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 14182500.0 5190600.0 5579300.0 3412600.0 True False 6804926.865841899 4746890.18794106 3059496.887970693 1.0 0.6975666721370091 0.44960025997166614 22.69814822615202 -7.263334701448806 0.18013196602679338 1.2121689207319193 1.963398643129019e-15 0.9999889724886141 0.0007473707038161666 0.10164334042804764 0.009902254674491559 0.018744290157812937 0.04325288635145491 5.453374192387332e-08 7.263334701448806 -1.2121689207319173 down NSNPALNDNLEK(ub)GLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSNPALNDNLEKGLLK 16 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 17350200.0 5595600.0 6230700.0 5523900.0 True False 5417970.74087659 8718651.002671264 4077024.876552145 1.0 1.6092096874743638 0.7525003495852233 22.36932117177768 -6.715711471226989 1.7745702483780323 1.372314752990552 0.7541284245799003 0.4923162791323783 0.25650071734726926 0.3637016017467246 2.2358965183965522 0.11487108195038159 0.28985333488037945 1.9243697825748292e-07 6.715711471226989 -0.6181863284106517 NSNPALNDNLEK(ub)GLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSNPALNDNLEKGLLK 16 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 11919500.0 5190600.0 3707300.0 3021600.0 True False 7109705.090690706 3543499.2275983305 2307960.3118053935 1.0 0.4984031239549038 0.3246211034586212 22.761358287674913 -13.999999999999998 0.14785097479433762 3.4177633803265888 0.1286204642058166 0.9995735707423226 0.0059130488113899515 11.95029551171869 0.12098327430752916 8.306383462050302 0.1763091772337034 1.0000000000000041e-14 13.999999999999998 -3.289142916120772 NSNPALNDNLEK(ub)GLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSNPALNDNLEKGLLK 16 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 17198600.0 5595600.0 9400300.0 2202700.0 True False 4652989.32711084 9349658.718086548 2663274.3858659132 1.0 2.009387527198991 0.5723792165927035 22.149726447211957 -6.717919169467585 1.7667110423147538 1.6154679681837592 0.5748686920218845 0.5026764416149803 0.42486790442367606 0.3593983700747438 2.1911586586537215 0.19102865556850004 0.4807476388567596 1.914612237919545e-07 6.717919169467585 -1.0405992761618745 NSNYCLPSYTAYK(ub)NYDYSEPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSNYCLPSYTAYKNYDYSEPGR 22 1 Q9Y4E8-2;Q9Y4E8-3;Q9Y4E8 Q9Y4E8-2 USP15 Ubiquitin carboxyl-terminal hydrolase 15 1 40131300.0 6064300.0 13727000.0 20340000.0 True False 9199986.45971568 11277309.600459477 16319790.084661312 1.0 1.225796325879375 1.773892837355944 23.13320030717693 -6.956090314008412 0.4874229382047124 0.9877203992106208 2.0351091343649723 0.9995965842755028 0.006526588632090987 0.08112849189876178 0.026525586504320027 0.007848070566878446 0.0452058874061195 1.106393679192328e-07 6.956090314008412 1.0473887351543514 NSNYCLPSYTAYK(ub)NYDYSEPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSNYCLPSYTAYKNYDYSEPGR 22 1 Q9Y4E8-2;Q9Y4E8-3;Q9Y4E8 Q9Y4E8-2 USP15 Ubiquitin carboxyl-terminal hydrolase 15 1 34661300.0 6064300.0 12822000.0 15775000.0 True False 7850355.895224275 12108444.428556167 12904111.865168734 1.0 1.5424070692033565 1.643761383228356 22.90432662926938 -11.594214371045146 0.28712006173409327 2.1718734255812128e-12 1.6758713539539447 0.9993681853978068 0.007104111031964249 4.137738114416518 0.15599065603665954 2.5798072776819163 0.03870031166663464 2.5455734280999785e-12 11.594214371045146 1.675871353951773 NSPDWGGVVILHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSPDWGGVVILHR 13 0 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3;K7EQ85 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 0 7553900.0 3585900.0 3968000.0 0.0 False True 4701149.625904993 3375989.8671428557 0.0 1.0 0.7181200633436469 0.0 22.164582167983003 -7.393187608047026 0.7646656140623698 0.9902363997219366 5.315025668608491e-18 0.9875058205555584 0.047058030463011755 0.11260509681118974 0.13881794527902186 0.040700485629547103 0.07285337842619043 4.0440115933426844e-08 7.393187608047026 -0.9902363997219366 down NSPDWGGVVILHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSPDWGGVVILHR 13 0 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3;K7EQ85 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 0 6768600.0 3585900.0 3182700.0 0.0 False True 4911704.1353037795 3042077.790218544 0.0 1.0 0.6193528165414217 0.0 22.227792229505894 -7.604802040944424 0.6765203809416136 0.9966196767585108 4.584958737804863e-21 0.9871380498412625 0.04673728506952945 0.12118590447919983 0.14679024069757826 0.04233833445391623 0.07716929303138247 2.4842652189936426e-08 7.604802040944424 -0.9966196767585108 down NSPVNTK(ub)NQAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSPVNTKNQAVK 12 1 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 1 3512310.0 728910.0 1010200.0 1773200.0 True False 955608.0687744799 859482.0977287575 1589726.273735462 1.0 0.8994085816280317 1.6635756077009765 19.86605950982564 -6.873756583638948 1.1139770325070117 0.9415818984247577 1.7116548857364648 0.9682933480680556 0.06036687705038443 0.13330674483445976 0.3069011092537523 0.041951225798357736 0.10002644934686246 1.3373448707851404e-07 6.873756583638948 0.7700729873117071 NSPVNTK(ub)NQAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSPVNTKNQAVK 12 1 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 1 22447000.0 1073600.0 2102200.0 19271200.0 True False 1039519.1556589287 2941619.4228281737 14223494.596392337 1.0 2.8297885679302803 13.682763342034205 19.987484912916813 -6.9360789447588775 0.6950815816954072 0.8660737584180566 16.30013640266998 0.9976039289328158 0.27399564185784125 0.0896017997110897 0.06310153408272576 0.2593689449593637 0.9513416014221588 1.158566736198246e-07 6.9360789447588775 15.434062644251924 NSPVNTK(ub)NQAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSPVNTKNQAVK 12 1 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 1 69524570.0 788070.0 7292500.0 61444000.0 True False 1195559.805634308 5991096.398437434 49299566.46813814 1.0 5.011122296185626 41.23555027176755 20.189254869289204 -6.927913249210559 0.7637243779644933 0.4043870244072733 48.29194638724787 0.9961120126248711 1.1283551351344938 0.09373600200979508 0.08309466631833458 1.0155024456953192 3.3160939792399637 1.1805564295162957e-07 6.927913249210559 47.8875593628406 NSPVNTK(ub)NQAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSPVNTKNQAVK 12 1 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 1 10452120.0 728910.0 982310.0 8740900.0 True False 998407.7250520863 938908.2961352237 6676479.4444863 1.0 0.9404056805412252 6.687127189583787 19.92926957134853 -6.904555902251822 0.9320001061061309 0.790010574833162 7.34944431839825 0.9887002017460442 0.28648984306178266 0.10812953542515415 0.15910405277024653 0.22841440017938386 0.6091115632254699 1.2457878695192242e-07 6.904555902251822 6.559433743565088 up NSPVNTK(ub)NQAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSPVNTKNQAVK 12 1 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 1 4701700.0 1073600.0 1825900.0 1802200.0 True False 892745.9685442477 1816063.5142872285 2179031.687568684 1.0 2.034244430415726 2.44081940926814 19.76789018835109 -9.985877337258493 0.22945382414423227 2.1400559173522864e-17 2.716784239646047 0.9992255365646393 0.01687927822957699 1.4652747578027046 0.10396879691256668 1.1366927204460546 0.20358843327990944 1.0330531415359582e-10 9.985877337258493 2.716784239646047 NSPVNTK(ub)NQAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSPVNTKNQAVK 12 1 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 1 21782870.0 788070.0 1308800.0 19686000.0 True False 1020172.1501821139 1235964.1294723353 16103349.995417535 1.0 1.2115250639332782 15.78493393741721 19.960381191381654 -6.910057987034364 0.8953188799668548 0.5496024869747511 17.670773140689075 0.9909438971616412 0.6585667074321112 0.10438029065217416 0.13855157002894994 0.539331424140008 1.48943790151634 1.2301045161924473e-07 6.910057987034364 17.121170653714323 up NSQEDSEDSEDKDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSQEDSEDSEDKDVK 15 1 Q9H1E3 Q9H1E3 NUCKS1 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 0 4455910.0 1614200.0 876110.0 1965600.0 False True 1562958.1045684072 1225945.2918532935 1450750.3932639791 1.0 0.7843750182874059 0.9282081132076071 20.575847676426005 -10.195200893178006 4.502731487790574 1.0000323664470436 0.8562915657471383 0.5710038243315654 0.05871961513021933 2.0148704828332174e-05 3.601281255266304e-06 0.05686853562436688 0.018951674288783374 6.379683106038879e-11 10.195200893178006 -0.14374080069990536 NSQFAGGPLGNPNTTAK(ub)VQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSQFAGGPLGNPNTTAKVQQR 21 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 117223000.0 39972000.0 46162000.0 31089000.0 True False 52403679.08939861 39274809.538066655 27872208.506745826 1.0 0.7494666447190736 0.5318750322700996 25.643164766388466 -6.972774437044664 0.17996577353984258 1.1682861508816385 0.10717161511072965 0.9999967178927804 0.0003464658263730795 0.07541220162167085 0.005675297914425484 0.008381703156456552 0.024421085786671782 1.0646958541417639e-07 6.972774437044664 -1.0611145357709089 NSQFAGGPLGNPNTTAK(ub)VQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSQFAGGPLGNPNTTAKVQQR 21 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 90637000.0 35218000.0 20621000.0 34798000.0 True False 34100023.86735851 28855072.837094404 25683359.88237682 1.0 0.84618922700272 0.7531771819949264 25.023269413235404 -13.999999999987429 0.05006631784914491 2.109947591039489 0.2144295033260336 0.9999754602085318 0.0005041557281642145 12.5641951694306 0.053334311120133225 1.9268480860083201 0.515733535625199 1.0000000000289465e-14 13.999999999987429 -1.8955180877134552 NSQFAGGPLGNPNTTAK(ub)VQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSQFAGGPLGNPNTTAKVQQR 21 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 265660000.0 99167000.0 65873000.0 100620000.0 True False 150443589.07880947 54117448.48190192 80732412.8966874 1.0 0.35971920646982597 0.5366291338236816 27.164647388859066 -10.82113474116819 10.844659636168412 1.0063397067896391 0.4481741701473471 0.928433094802199 0.07222317540829776 0.010923837755225157 0.00018017080682426224 0.06900389446829544 0.023309929630546188 1.509611719928415e-11 10.82113474116819 -0.558165536642292 NSQFAGGPLGNPNTTAK(ub)VQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSQFAGGPLGNPNTTAKVQQR 21 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 128770000.0 39972000.0 42329000.0 46469000.0 True False 54750728.60268349 40458764.816715546 35493979.25909618 1.0 0.7389630393837817 0.6482832313825413 25.706374827911358 -13.999999999999998 0.1474594762716667 2.257546413173099 0.5455434650124511 0.9995749388069423 0.0030739182589926755 11.949073102794355 0.1208009052005161 4.3090930945795085 0.09238533509855583 1.0000000000000041e-14 13.999999999999998 -1.7120029481606478 NSQFAGGPLGNPNTTAK(ub)VQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSQFAGGPLGNPNTTAKVQQR 21 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 114707000.0 35218000.0 46516000.0 32973000.0 True False 29285327.42193673 46265409.07529691 39867501.85007342 1.0 1.5798153255626886 1.3613473148403288 24.80367468866968 -10.169549848941516 4.517527559138534 0.9999222359990791 1.4705813202084959 0.8608467231789888 0.08918919198770883 62510898.933342755 8.72420844371783 54215.17796494165 0.030531832696893794 6.767841062140694e-11 10.169549848941516 0.4706590842094167 NSQFAGGPLGNPNTTAK(ub)VQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSQFAGGPLGNPNTTAKVQQR 21 1 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 1 259131000.0 99167000.0 62945000.0 97019000.0 True False 128373636.37381153 59442055.41689813 79362537.49900514 1.0 0.46303943002602693 0.6182152328217078 26.935773710951516 -10.718153233889531 10.340888076418828 1.000559267122402 0.5406273314239028 0.9211654480266432 0.06335025621269423 0.0008176718188020575 2.2286056094732273e-05 0.061402407804563894 0.020446207274144812 1.9135806294531164e-11 10.718153233889531 -0.4599319356984991 NSQSFFSGLFGGSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSQSFFSGLFGGSSK 15 0 P54920;M0R0Y2;M0R2M1 P54920 NAPA Alpha-soluble NSF attachment protein 0 74475000.0 19418000.0 18747000.0 36310000.0 False True 25457186.044179518 15950020.675233647 32552989.51011422 1.0 0.6265429591296258 1.278734792353732 24.601569621374168 -6.751429777635876 1.644851454175441 0.7807793745285478 1.2801505122736179 0.6549944948033793 0.15694020497253294 0.29755057450394895 1.5843836839127619 0.0753632876900541 0.18266646839197506 1.772434612181051e-07 6.751429777635876 0.49937113774507 NSQSFFSGLFGGSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSQSFFSGLFGGSSK 15 0 P54920;M0R0Y2;M0R2M1 P54920 NAPA Alpha-soluble NSF attachment protein 0 63890000.0 21478000.0 13367000.0 29045000.0 False True 20796192.6464628 18704512.807984132 21437243.168677405 1.0 0.8994200585637275 1.0308253791024407 24.309816089075497 -6.702151506764803 1.8230085366547604 0.9376771758158813 1.030453273887141 0.42789589958470264 0.04243941137084633 0.3910559549613184 2.5280692853069544 0.018561022408227622 0.04761103033658239 1.985402174650745e-07 6.702151506764803 0.09277609807125975 NSQSFFSGLFGGSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSQSFFSGLFGGSSK 15 0 P54920;M0R0Y2;M0R2M1 P54920 NAPA Alpha-soluble NSF attachment protein 0 27299100.0 6551100.0 10670000.0 10078000.0 False True 9938497.649562746 8765855.134909488 8086078.882655675 1.0 0.8820100828111732 0.8136117920208422 23.24459635296918 -13.999999999957872 0.06055113189422378 1.7463919823653618 0.5085945313255146 0.9999527764815298 0.0005290060503587391 12.458356414086893 0.06312776091867218 1.4044923314157602 0.2856301636545029 1.0000000000970035e-14 13.999999999957872 -1.2377974510398473 NSQSFFSGLFGGSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSQSFFSGLFGGSSK 15 0 P54920;M0R0Y2;M0R2M1 P54920 NAPA Alpha-soluble NSF attachment protein 0 92747000.0 19418000.0 34992000.0 38337000.0 False True 26597359.351718944 33445937.736930024 29282590.175299004 1.0 1.2574909145921838 1.100958549609043 24.66477968289706 -10.256921133268335 4.935784031409695 0.9999614818723183 1.1792247321006695 0.6360909278981086 0.06390407040716328 2.7095683041699556e-05 4.079234462103114e-06 0.06188813818203206 0.020624950036741696 5.534506052597257e-11 10.256921133268335 0.1792632502283512 NSQSFFSGLFGGSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSQSFFSGLFGGSSK 15 0 P54920;M0R0Y2;M0R2M1 P54920 NAPA Alpha-soluble NSF attachment protein 0 52547000.0 21478000.0 15054000.0 16015000.0 False True 17859908.63673002 14972901.114014972 19363662.45500639 1.0 0.8383526152660302 1.0841971730574147 24.090221364509773 -6.729316498226716 1.725465695634371 0.9026500732817062 1.084040144404111 0.5562331791497008 0.06795633685612151 0.33750823145318765 1.968212653584758 0.03121293122055092 0.07752036111657433 1.8650200358153282e-07 6.729316498226716 0.1813900711224048 NSQSFFSGLFGGSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSQSFFSGLFGGSSK 15 0 P54920;M0R0Y2;M0R2M1 P54920 NAPA Alpha-soluble NSF attachment protein 0 24215500.0 6551100.0 10315000.0 7349400.0 False True 8480528.091486854 9740961.18238626 6011884.611212115 1.0 1.1486267219802841 0.7089045099970982 23.015722675061628 -6.81551980172335 1.391100546394396 1.0804906779566952 0.7001936364689665 0.8737705970106328 0.06488606110724841 0.1993727245678608 0.7592768788598651 0.03666414276211 0.08462422597445825 1.529256018167029e-07 6.81551980172335 -0.3802970414877287 NSRPEANEALER ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSRPEANEALER 12 1 Q9Y696 Q9Y696 CLIC4 Chloride intracellular channel protein 4 0 8023690.0 2104000.0 973890.0 4945800.0 False True 2037209.6716713747 1362769.3557692566 3650346.609180392 1.0 0.668939174361571 1.7918364810164886 20.958163040896295 -6.827741960865033 1.3378825925011735 0.8228014253652597 1.8206994137944312 0.9012900448260621 0.14801411104713721 0.1836214377197277 0.6435686992382698 0.08688180474728485 0.19997603495914676 1.486818783784273e-07 6.827741960865033 0.9978979884291715 NSSAQAFLGPENPEEPYLDGINYNCVAPGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSSAQAFLGPENPEEPYLDGINYNCVAPGKR 31 1 Q14683;G8JLG1;V9GY57 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 6552000.0 1862500.0 3054500.0 1635000.0 True False 2441755.5364756584 2598780.5063477466 1465825.8840274534 1.0 1.064308227226847 0.6003163961872995 21.219487337229847 -6.871856840552724 1.1242961430563212 1.0368085486238274 0.5721746434081543 0.9664980419228733 0.037569149575360256 0.1350833459675447 0.3180108674862211 0.025903995366910414 0.06153112361821929 1.3432076588559086e-07 6.871856840552724 -0.46463390521567316 NSSAQAFLGPENPEEPYLDGINYNCVAPGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSSAQAFLGPENPEEPYLDGINYNCVAPGKR 31 1 Q14683;G8JLG1;V9GY57 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 102733000.0 17614000.0 37915000.0 47204000.0 True False 26721725.755888052 31148772.018752877 37874108.70975182 1.0 1.1656721689050842 1.417352646148102 24.671509847886636 -6.965045580160987 0.3572695641930632 0.9776248769421707 1.6139882725964603 0.9999140804681531 0.0015904613018776152 0.07794549856150534 0.014805446635441291 0.00339606182219487 0.021532335040250598 1.0838131594772777e-07 6.965045580160987 0.6363633956542896 NSSAQAFLGPENPEEPYLDGINYNCVAPGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSSAQAFLGPENPEEPYLDGINYNCVAPGKR 31 1 Q14683;G8JLG1;V9GY57 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 16054200.0 6747800.0 1969100.0 7337300.0 True False 5611094.678225478 1958492.0674642522 8871495.506157877 1.0 0.34903921244893876 1.5810632354119372 22.419850825503044 -6.763104503853244 1.6004581883723246 0.6233673100776699 1.5863290849719316 0.7036960442687096 0.27393349007094303 0.2776996012976986 1.4025403007746604 0.13499480666885355 0.3234695515224971 1.7254226552798302e-07 6.763104503853244 0.9629617748942617 NSSAQAFLGPENPEEPYLDGINYNCVAPGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSSAQAFLGPENPEEPYLDGINYNCVAPGKR 31 1 Q14683;G8JLG1;V9GY57 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 87754000.0 17614000.0 26915000.0 43225000.0 True False 22801670.22384782 25417156.589813527 35358493.52595366 1.0 1.114705911465653 1.5506975225425768 24.442636169979085 -6.946049103129704 0.600664211466901 0.9950962841451818 1.692650853625705 0.9988535485222115 0.008032526244338466 0.08511226722070618 0.04283626711391824 0.008238733052354211 0.036647487933318366 1.1322723366063535e-07 6.946049103129704 0.6975545694805232 NSSTYWEGK(ub)ADMETLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSSTYWEGKADMETLQR 17 1 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 1 3946200.0 1035700.0 1468600.0 1441900.0 True False 1357812.7297330678 1249490.6045579624 1292706.0196814584 1.0 0.9202230743584202 0.9520503022059539 20.372853085345835 -10.14800233120212 4.42309179095972 1.0000106929863317 0.9361366882808241 0.8429743911090496 0.01299341136765789 1.3947970414552732e-06 2.6867960760548017e-07 0.012582960363449627 0.004193605485224454 7.112096960178997e-11 10.14800233120212 -0.06387400470550764 NSSTYWEGK(ub)ADMETLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSSTYWEGKADMETLQR 17 1 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 1 6901300.0 1035700.0 2079000.0 3786600.0 True False 1418626.2787401017 1987142.9056663685 2892283.0674749515 1.0 1.4007515125344872 2.038791407447789 20.436063146868726 -6.964248245454942 0.3707335585651772 0.9513404872303307 2.5104370513546104 0.9998967925548382 0.00434562484089952 0.07821706420738607 0.015765516427297645 0.008400581776925122 0.05416702966000704 1.0858047933557013e-07 6.964248245454942 1.5590965641242795 up NSSYFVEWIPNNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSSYFVEWIPNNVK 14 0 A0A0B4J269;Q13509;Q13509-2;P04350;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BUF5;K7ESM5;Q9BVA1 A0A0B4J269;P04350;P07437;P68371;Q13885;Q9BUF5;Q9BVA1 TUBB3;TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB6;TUBB2B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 562510000.0 133110000.0 199990000.0 229410000.0 False True 174508499.03907356 170152271.55491447 205672853.8561085 1.0 0.9750371614669399 1.1785835932842277 27.3787220604217 -6.87620711787541 1.1006743904995133 0.9851823143898327 1.1920026466562448 0.9704978153618982 0.015569128458305898 0.1310457716739366 0.2930064012262172 0.010930466396555006 0.026197233154079742 1.3298200668502033e-07 6.87620711787541 0.20682033226641205 NSSYFVEWIPNNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSSYFVEWIPNNVK 14 0 A0A0B4J269;Q13509;Q13509-2;P04350;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BUF5;K7ESM5;Q9BVA1 A0A0B4J269;P04350;P07437;P68371;Q13885;Q9BUF5;Q9BVA1 TUBB3;TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB6;TUBB2B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 404425000.0 138250000.0 70405000.0 195770000.0 False True 133861329.42422387 98518083.65722482 144491964.02588996 1.0 0.7359712030425775 1.0794152773425418 26.996164006500784 -6.701378117194978 1.8263354190397594 0.8362671941638607 1.0784076746341005 0.4239666969534752 0.11142223515866455 0.3926521735024091 2.547266225321781 0.048658087980224224 0.12490566340283812 1.988940919456032e-07 6.701378117194978 0.24214048047023973 NSSYFVEWIPNNVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSSYFVEWIPNNVK 14 0 A0A0B4J269;Q13509;Q13509-2;P04350;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BUF5;K7ESM5;Q9BVA1 A0A0B4J269;P04350;P07437;P68371;Q13885;Q9BUF5;Q9BVA1 TUBB3;TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB6;TUBB2B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 519158000.0 69048000.0 347470000.0 102640000.0 False True 104750864.08496419 285461263.70449865 82353159.01128979 1.0 2.725144715493315 0.7861811903001826 26.64238690379633 -6.672016207516377 1.930409369501073 2.09923848597594 0.7939736910908141 0.28797549284616775 0.7324645526906726 0.45647647308630057 3.281419602987936 0.30527164709482646 0.8134165682631982 2.1280596270485992e-07 6.672016207516377 -1.305264794885126 NSSYFVEWIPNNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSSYFVEWIPNNVK 14 0 A0A0B4J269;Q13509;Q13509-2;P04350;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BUF5;K7ESM5;Q9BVA1 A0A0B4J269;P04350;P07437;P68371;Q13885;Q9BUF5;Q9BVA1 TUBB3;TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB6;TUBB2B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 545600000.0 133110000.0 179490000.0 233000000.0 False True 182324364.16249374 171559538.30594346 177970198.78562912 1.0 0.9409578313573259 0.9761185763797096 27.441932121944593 -10.038104248720277 5.07832383264218 1.0000005405426815 0.9585382038683004 0.6496193048247854 0.014354314047579739 8.785236951693264e-08 1.661907114956338e-08 0.01389868613405578 0.004632834937600555 9.160005855302502e-11 10.038104248720277 -0.04146233667438115 NSSYFVEWIPNNVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSSYFVEWIPNNVK 14 0 A0A0B4J269;Q13509;Q13509-2;P04350;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BUF5;K7ESM5;Q9BVA1 A0A0B4J269;P04350;P07437;P68371;Q13885;Q9BUF5;Q9BVA1 TUBB3;TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB6;TUBB2B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 321639000.0 138250000.0 90102000.0 93287000.0 False True 114961000.51345207 89616602.64215328 112792880.38964587 1.0 0.7795391675602794 0.981140385747143 26.77656928193506 -10.399207295807123 7.3863726361079936 1.000004367883219 0.8803397766878316 0.31960479830197 0.08230335268021932 5.9202016009046316e-06 4.815269513053775e-07 0.0796927875293161 0.0265632928556271 3.9883448674579447e-11 10.399207295807123 -0.1196645911953873 NSSYFVEWIPNNVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSSYFVEWIPNNVK 14 0 A0A0B4J269;Q13509;Q13509-2;P04350;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BUF5;K7ESM5;Q9BVA1 A0A0B4J269;P04350;P07437;P68371;Q13885;Q9BUF5;Q9BVA1 TUBB3;TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB6;TUBB2B Tubulin beta-3 chain;Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-6 chain;Tubulin beta-2B chain 0 311747000.0 69048000.0 152760000.0 89939000.0 False True 89383997.139562 144258771.71316785 73571024.85207053 1.0 1.613921689896299 0.8230894478482376 26.413513225888778 -6.6995272239208905 1.8330537437025793 1.3814052021493177 0.8255002669472816 0.4151510880114364 0.2591668988171457 0.396482960197789 2.589810749276435 0.11282144810322153 0.29026278685137585 1.9974355544826534e-07 6.6995272239208905 -0.5559049352020361 NSSYFVEWIPNNVK(ub)TAVCDIPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSSYFVEWIPNNVKTAVCDIPPR 23 1 P04350;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P04350;P07437;P68371;Q13885;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 62117600.0 39903400.0 7231900.0 14982300.0 True False 38636688.409016885 10119635.383860275 11057986.170634365 1.0 0.2619177729916054 0.286204295087922 25.203468108782992 -10.192529959542673 5.365508473473215 1.000033760802735 0.2740610340397668 0.9991612598468284 0.009914931127644374 4.004391386728279e-06 6.026058207510753e-07 0.009600535549454588 0.0032000302612729212 6.419039386249171e-11 10.192529959542673 -0.7259727267629682 NSSYFVEWIPNNVK(ub)TAVCDIPPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSSYFVEWIPNNVKTAVCDIPPR 23 1 P04350;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P04350;P07437;P68371;Q13885;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 322518000.0 34126000.0 60122000.0 228270000.0 True False 51771636.94478454 49392759.36466998 183152334.44570455 1.0 0.9540505628081323 3.537696415530382 25.62565859907615 -6.902851327377893 0.9430543433229448 0.90082263517874 3.825172428455504 0.9879325717191797 0.13261948773943835 0.10933719069511652 0.16581444840549278 0.10487748453132657 0.2769954911404654 1.2506871063639028e-07 6.902851327377893 2.924349793276764 up NSSYFVEWIPNNVK(ub)TAVCDIPPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSSYFVEWIPNNVKTAVCDIPPR 23 1 P04350;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P04350;P07437;P68371;Q13885;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 68224500.0 39903400.0 5862000.0 22459100.0 True False 33181445.12035075 5830420.242484099 27155193.97085444 1.0 0.17571327051419477 0.8183849097699393 24.98387338421727 -10.49216104548507 8.389941986074879 1.0000275921937685 0.49704909015358933 0.44952238630059793 0.26236959805576615 0.000135420512696222 8.197004772515231e-06 0.2540521351185879 0.08467942365175969 3.219874572982559e-11 10.49216104548507 -0.5029785020401791 NSSYFVEWIPNNVK(ub)TAVCDIPPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSSYFVEWIPNNVKTAVCDIPPR 23 1 P04350;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P04350;P07437;P68371;Q13885;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 259350000.0 34126000.0 48186000.0 177038000.0 True False 44176779.72402805 45504406.74110178 144818900.5632802 1.0 1.0300525983416493 3.2781678852094376 25.3967849211686 -6.909812207202376 0.8969922793733298 0.9299792787052086 3.5675549616247406 0.9908509572013177 0.10205211582335509 0.10454294749726738 0.13943423369160188 0.08347384586682334 0.23013290995153304 1.2308008650066618e-07 6.909812207202376 2.637575682919532 up NSSYVHGGLDSNGK(ub)PADAVYGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSSYVHGGLDSNGKPADAVYGQK 23 1 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 42141800.0 19553000.0 15850000.0 6738800.0 True False 29663330.51577602 13021443.663384773 5406873.226279042 1.0 0.4389744319660769 0.18227465130402243 24.822177252861874 -9.523225158823491 0.23022897928549985 1.456364232511649 1.4480313610623595e-20 0.9992482694581917 0.009361890831395233 0.9364538784554075 0.09243512261005284 0.4248309641281255 0.12232660529447256 2.9976080141251647e-10 9.523225158823491 -1.456364232511649 NSSYVHGGLDSNGK(ub)PADAVYGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSSYVHGGLDSNGKPADAVYGQK 23 1 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 16961100.0 2619500.0 12704600.0 1637000.0 True False 2178230.313526134 12636157.798134347 1979289.131367185 1.0 5.801111902477773 0.9086684355994928 21.054725073707328 -6.6504881853122155 2.0067711637008228 4.114269619297435 0.9292419649172876 0.19602184224311137 2.0489284361590294 0.5073484107507445 3.916833178983822 0.8278798643842911 2.2695321542645486 2.2362060323684188e-07 6.6504881853122155 -3.1850276543801472 NSSYVHGGLDSNGK(ub)PADAVYGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSSYVHGGLDSNGKPADAVYGQK 23 1 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 58928300.0 19553000.0 13188300.0 26187000.0 True False 25311743.94725197 12454359.511552583 21421234.70131054 1.0 0.49203877605220164 0.8462962783580223 24.593303574954323 -10.125724098234425 5.895965766893419 1.0000023169002874 0.6691675272051038 0.5376431870649604 0.14462501970038888 4.404686274502438e-06 6.529751937821677e-07 0.14003355377404147 0.04667752439537135 7.486449540963176e-11 10.125724098234425 -0.33083478969518365 NSSYVHGGLDSNGKPADAVYGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSSYVHGGLDSNGKPADAVYGQK 23 1 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 15501650.0 2772050.0 7869500.0 4860100.0 False True 3634184.394570383 6695401.275070738 4357223.473371147 1.0 1.842339449003726 1.1989549786964617 21.793200191533305 -10.408938196114395 5.372994758145245 0.9996526465841129 1.5206472138501008 0.4661375339194409 0.26266061011396286 0.0010936196570313131 0.00012030462301396857 0.2544849659365662 0.08477334738966802 3.899974827646535e-11 10.408938196114395 0.5209945672659879 NSSYVHGGLDSNGKPADAVYGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSSYVHGGLDSNGKPADAVYGQK 23 1 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 12705500.0 3666300.0 2242900.0 6796300.0 False True 3549915.3133311556 3138501.6665689824 5016145.1453703595 1.0 0.8841060672018927 1.4130323409499392 21.759353177464174 -6.849278402565425 1.2385071216118675 0.9381888945073711 1.4338911783050639 0.939256115824154 0.05594879914697719 0.15825345392721865 0.4674770892768483 0.035354688970933947 0.08177906567695355 1.4148864824287936e-07 6.849278402565425 0.49570228379769277 NSSYVHGGLDSNGKPADAVYGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSSYVHGGLDSNGKPADAVYGQK 23 1 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 14287050.0 2772050.0 6282700.0 5232300.0 False True 3796951.7968345014 6005109.539889419 3996538.5026010666 1.0 1.5815606468577892 1.0525649827666919 21.856410253056197 -10.164587337044157 3.856560723067479 0.9998115458608715 1.317062814656254 0.32386224060733704 0.21596157611186048 152485216.3455833 257653718.3949894 351475.40175984486 0.079033808245399 6.845618032011008e-11 10.164587337044157 0.31725126879538246 NSSYVHGGLDSNGKPADAVYGQK(ub)EIHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSSYVHGGLDSNGKPADAVYGQKEIHR 27 2 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 24813500.0 8133200.0 14473000.0 2207300.0 True False 10662703.962020827 12313684.815312142 1978909.7699166934 1.0 1.1548369774845006 0.18559173892150754 23.346070002677177 -6.865992413632414 1.1549963595415995 1.085779415064545 0.1329681664653073 0.9605219911355215 0.08447074250096118 0.1407602474142852 0.35346094582927867 0.05688321057251844 0.13382122593120235 1.3614684647391536e-07 6.865992413632414 -0.9528112485992377 down NSSYVHGGLDSNGKPADAVYGQK(ub)EIHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSSYVHGGLDSNGKPADAVYGQKEIHR 27 2 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 36775900.0 18810700.0 14433200.0 3532000.0 True False 18213564.624956608 20196452.02814369 2606863.2422712543 1.0 1.1088687164768443 0.143127569805818 24.118509967826245 -6.878893119915343 1.0860116223503995 1.0665277020819008 0.07613792300242851 0.972779038435699 0.07125609675330913 0.12861238045872175 0.27828128787859274 0.05059419671159859 0.12200723965827869 1.3216208457048614e-07 6.878893119915343 -0.9903897790794723 down NSSYVHGGLDSNGKPADAVYGQK(ub)EIHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSSYVHGGLDSNGKPADAVYGQKEIHR 27 2 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 34571200.0 18813000.0 7076700.0 8681500.0 True False 28540696.414529473 5813807.594490541 6965597.719763373 1.0 0.2037023732725335 0.24405843566652888 24.76651720230237 -10.151708657128525 6.3559420572971765 1.0000031494738717 0.2238804044695293 0.9979763200655989 0.016475293482208282 7.352932788515756e-07 9.813554315689268e-08 0.01595219894154084 0.005317378106705041 7.05165965102226e-11 10.151708657128525 -0.7761227450043424 NSSYVHGGLDSNGKPADAVYGQK(ub)EIHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSSYVHGGLDSNGKPADAVYGQKEIHR 27 2 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 18527800.0 8133200.0 8929600.0 1465000.0 True False 11140263.831465652 8535060.745761625 1118997.1726220904 1.0 0.7661452973541223 0.10044620033696915 23.40928006420007 -7.208145427531719 0.6592664852635012 0.9984225947699296 2.08059806574473e-22 0.9967840244381188 0.021611235553120337 0.08880999597727855 0.06853185509265239 0.02012820008929201 0.056309115038006285 6.19233684217963e-08 7.208145427531719 -0.9984225947699296 down NSSYVHGGLDSNGKPADAVYGQK(ub)EIHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSSYVHGGLDSNGKPADAVYGQKEIHR 27 2 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 35085500.0 18810700.0 14421000.0 1853800.0 True False 15641930.505304847 14343311.210655635 2241421.008997239 1.0 0.91697832347428 0.14329567621062358 23.89891524326052 -6.934217161130156 0.7735834967597212 1.01256224062142 5.280927278798067e-19 0.9960088417575131 0.024371740967500305 0.09229987565677962 0.08491247818000465 0.02188708016130002 0.06956098261236174 1.1635440746759e-07 6.934217161130156 -1.01256224062142 down NSSYVHGGLDSNGKPADAVYGQK(ub)EIHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSSYVHGGLDSNGKPADAVYGQKEIHR 27 2 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 37909800.0 18813000.0 11538000.0 7558800.0 True False 24353799.35967124 10895900.157282852 6183175.959837553 1.0 0.4474004239078177 0.2538895828334944 24.53764352439482 -13.999999999998584 0.14628013149817826 3.657935215561765 0.031607274427919364 0.9995791265991613 0.0064856472735886515 11.945692032747504 0.12024897728432991 9.03620001193921 0.1996743101016609 1.0000000000032599e-14 13.999999999998584 -3.626327941133846 NSSYVHGGVDASGKPQEAVYGQNDIHHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSSYVHGGVDASGKPQEAVYGQNDIHHK 28 1 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4;D6RBM9;D6REX8;D6RBR0;D6RE13;D6RBW8 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 7583330.0 1533500.0 802630.0 5247200.0 False True 1484819.881895461 1123124.3446601569 3872800.9073742153 1.0 0.7564044355510797 2.6082630995150433 20.50185650287101 -6.873782057461369 1.1138354321261146 0.8585024655142359 2.7248355058658675 0.9683170539969493 0.1462422526549244 0.13328323805064451 0.3067522655423043 0.10164008620753813 0.24235888290184476 1.337266430261316e-07 6.873782057461369 1.8663330403516316 up NSTFSEIFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSTFSEIFK 9 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 20059500.0 7934700.0 3067900.0 9056900.0 False True 7682817.2917351965 4292928.468887152 6684626.188824044 1.0 0.5587700847064627 0.8700748612120506 22.87320401405948 -10.120211076081697 5.8716294592744855 1.0000019495279453 0.7144224729592453 0.5287592985765409 0.12708964282168267 3.2434675517507724e-06 4.859289663697341e-07 0.1230548572586088 0.0410180058436461 7.582089802508738e-11 10.120211076081697 -0.2855794765687 NSTIPTK(ub)QTQIFTTYSDNQPGVLIQVYEGER ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSTIPTKQTQIFTTYSDNQPGVLIQVYEGER 31 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 1 32542400.0 11346000.0 5789400.0 15407000.0 True False 10985827.440486403 8101137.611322171 11371444.499907471 1.0 0.7374171545300996 1.035101321362462 23.38914020027491 -6.673847795803798 1.9238628406604175 0.8329493491000526 1.03391652724915 0.2961234101247461 0.11144206028607746 0.45235586858418897 3.2314567006795762 0.046574892184135366 0.12380959295666943 2.1191036727953911e-07 6.673847795803798 0.20096717814909737 NSTIPTK(ub)QTQIFTTYSDNQPGVLIQVYEGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSTIPTKQTQIFTTYSDNQPGVLIQVYEGER 31 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 1 269718000.0 39279000.0 92549000.0 137890000.0 True False 59589114.679546155 76032907.86136258 110635981.06066602 1.0 1.2759529701061445 1.8566475044248578 25.82854547758159 -6.959038667823614 0.4487831740350358 0.9810391503697987 2.174534886163975 0.999732847787231 0.005835495034196689 0.08004642485988124 0.02241438502953113 0.00774765692668248 0.04804179265886112 1.0989079927549017e-07 6.959038667823614 1.1934957357941762 NSTIPTK(ub)QTQIFTTYSDNQPGVLIQVYEGER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSTIPTKQTQIFTTYSDNQPGVLIQVYEGER 31 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 1 28504000.0 11346000.0 8460900.0 8697100.0 True False 9434701.713024436 8415319.452342845 10515623.399153039 1.0 0.8919539491879906 1.1145687186523778 23.169545475709185 -6.774762504828532 1.5565427067993705 0.9384043141650238 1.1160427949721177 0.7483205109961308 0.045599952480736894 0.2588032898382141 1.238117730436077 0.02308440654282532 0.05470680199577315 1.6797223279374408e-07 6.774762504828532 0.17763848080709388 NSTIPTK(ub)QTQIFTTYSDNQPGVLIQVYEGER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSTIPTKQTQIFTTYSDNQPGVLIQVYEGER 31 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 1 218304000.0 39279000.0 89909000.0 89116000.0 True False 50847439.80484375 84905485.11363705 72897802.40737729 1.0 1.6698084591773075 1.4336572831820926 25.599671799674038 -10.263380518493832 5.171558794071732 0.9999144425363006 1.5517328711798275 0.8791988953459307 0.0964083138915214 9.511790785936926e-05 1.3548551195537783e-05 0.09336132654633154 0.03111564951141946 5.4527989045996574e-11 10.263380518493832 0.5518184286435269 NSVCHTATVIANSFMHCGTTSDQFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSVCHTATVIANSFMHCGTTSDQFLR 26 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 4127120.0 766320.0 1935100.0 1425700.0 False True 1004652.9410534371 1646390.6229607218 1278182.2402800838 1.0 1.6387655434864754 1.27226247796561 19.938265775509485 -10.123992044085472 4.360234773600326 0.9999459632317215 1.4555140105301445 0.6731619702157141 0.14962425030020735 104398815.33948576 10.189634971667479 72328.31543010316 0.051220360594552206 7.516366632520414e-11 10.123992044085472 0.45556804729842304 NSVCHTATVIANSFMHCGTTSDQFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSVCHTATVIANSFMHCGTTSDQFLR 26 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 6896350.0 766320.0 893930.0 5236100.0 False True 1049649.213019325 854433.2167688009 3999441.0208645146 1.0 0.814017870133029 3.8102643923869466 20.001475837032377 -6.892120554275101 1.0097766067637228 0.8470962639383952 4.078913865040807 0.9822204450906458 0.182770767122546 0.11743860488358074 0.21194341847412357 0.13751826070197115 0.3455512201357151 1.2819746744275023e-07 6.892120554275101 3.231817601102412 up NSVEVALNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSVEVALNK 9 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 22736600.0 8119000.0 6527900.0 8089700.0 False True 10644087.624507854 5553962.765554908 7252655.445881873 1.0 0.5217885234960854 0.6813787805713607 23.343548956321154 -10.730509152361474 7.090434685554008 1.0048924893835884 0.6015836520337409 0.8925884513164596 0.06515244962566956 0.005068429795233421 0.0001926389971362909 0.06345333315058155 0.02102786269706966 1.8599053669944307e-11 10.730509152361474 -0.40330883734984757 NSVEVALNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSVEVALNK 9 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 19318200.0 8119000.0 4556700.0 6642500.0 False True 11120813.707725106 4355369.927008147 5073678.306581728 1.0 0.3916412990519459 0.4562326498696119 23.406759017844045 -10.172720641242709 5.329093072826847 1.0000224812937768 0.42393697446476897 0.9906589822337625 0.02636930855068434 7.043573921088173e-06 1.0934221766589888e-06 0.025532967850076006 0.008510657738894147 6.71860886666919e-11 10.172720641242709 -0.5760855068290078 NSVEVALNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSVEVALNK 9 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 2541600.0 2541600.0 0.0 0.0 False True 2113453.011970993 0.0 0.0 1.0 0.0 0.0 21.011170606864397 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 NSVFQQGMK(ub)NK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSVFQQGMKNK 11 1 P05023-4;P05023;P05023-3;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9;Q5TC05 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 1 17038260.0 2318960.0 1062000.0 13657300.0 True False 3040179.0168405846 903553.7396435766 12244173.606072234 1.0 0.2972041233882891 4.027451521192534 21.535724846645717 -6.857965394101438 1.1958990095064004 0.6205400615349864 4.2012564843337294 0.9511248226238133 0.35780034855054244 0.148915720857102 0.40584537035580515 0.2335302740910351 0.5439676270211857 1.3868663341755166e-07 6.857965394101438 3.580716422798743 up NSVFQQGMK(ub)NK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSVFQQGMKNK 11 1 P05023-4;P05023;P05023-3;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9;Q5TC05 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 1 14842450.0 843950.0 6828600.0 7169900.0 True False 817159.2692048748 9555295.590678569 5291888.097610601 1.0 11.693308698530965 6.475956765147874 19.64025777006376 -9.237938465636597 9.206930484482502 1.0001029925784588 9.084632731843033 0.7619920855696961 2.129975008395204 0.0 0.0 2.0623394334571725 0.6874464778190573 5.781779625439099e-10 9.237938465636597 8.084529739264575 NSVFQQGMK(ub)NK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSVFQQGMKNK 11 1 P05023-4;P05023;P05023-3;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9;Q5TC05 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 1 75460600.0 5398200.0 63179000.0 6883400.0 True False 8189464.061282766 51904213.83021992 5522892.972898608 1.0 6.337925588514011 0.6743900371953673 22.965337610759573 -6.65954603325722 1.9745380727359272 4.437286523696962 0.6980539834643162 0.23362722108321643 2.273024169727302 0.48554420748495986 3.638630941940268 0.9302111180957483 2.5195717096369514 2.1900496803723063e-07 6.65954603325722 -3.7392325402326456 NSVFQQGMK(ub)NK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSVFQQGMKNK 11 1 P05023-4;P05023;P05023-3;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9;Q5TC05 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 1 9320630.0 2318960.0 862770.0 6138900.0 True False 3176342.17953765 824649.9686011418 4689018.254614153 1.0 0.25962252238238964 1.4762320901133796 21.59893490816861 -6.741992706904468 1.6794888671653128 0.5604989877257043 1.4772481700941635 0.6138312616555184 0.3110639550054403 0.31421612170858926 1.741023430190044 0.14648050424773584 0.3586544670136158 1.8113705106603727e-07 6.741992706904468 0.9167491823684593 NSVFQQGMK(ub)NK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSVFQQGMKNK 11 1 P05023-4;P05023;P05023-3;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9;Q5TC05 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 1 22837050.0 843950.0 8319600.0 13673500.0 True False 701781.8183242534 8274780.663488693 16532565.630879158 1.0 11.791101518200614 23.55798511616669 19.420663045498035 -7.4405265934780065 0.36889341944184106 1.1949525585774792e-21 30.123610358931295 0.9988386834608168 0.31393185129570306 0.1499314899125299 0.048861217567862304 0.6347688527076903 2.2822018540083664 3.626380798769215e-08 7.4405265934780065 30.123610358931295 NSVFQQGMK(ub)NK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSVFQQGMKNK 11 1 P05023-4;P05023;P05023-3;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9;Q5TC05 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 1 46433100.0 5398200.0 35424000.0 5610900.0 True False 6988076.314430289 33452623.259801403 4589773.772695734 1.0 4.787100448620196 0.6568007511906975 22.736463932852022 -6.665608158882944 1.9536688605242474 3.426400567329073 0.67401606992415 0.2595503220461969 1.6103294680562212 0.4712059127882396 3.4632039854025445 0.6647027241732764 1.7856801427653193 2.15969210720447e-07 6.665608158882944 -2.752384497404923 NSVLK(ub)FEQAQMLDPYLIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSVLKFEQAQMLDPYLIK 18 1 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 84782700.0 5867700.0 29515000.0 49400000.0 True False 8901729.886330443 24247817.64825242 39636068.3472108 1.0 2.7239444420221663 4.45262537207248 23.085654293708618 -6.971091205103557 0.23063847279923244 0.3025443646040863 6.923457023545171 0.999989687899206 0.004526340175288844 0.07595017771570188 0.0077514030584013805 0.0442095249078249 0.17148021609547265 1.0688303932401326e-07 6.971091205103557 6.6209126589410845 NSVNFK(ub)NIYVLQELDNPGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSVNFKNIYVLQELDNPGAK 20 1 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 15810000.0 2079800.0 3623200.0 10107000.0 True False 2726637.940811852 3082632.6831229804 9061224.59318988 1.0 1.130561794429198 3.323222514277754 21.378691712674716 -6.919105559669984 0.8313326478605672 0.9500428979430801 3.6696363861836523 0.9939288413466224 0.08303976100156484 0.09870100411697287 0.10836215541273292 0.07121038616264885 0.21151904870891164 1.2047430797812887e-07 6.919105559669984 2.719593488240572 up NSVNFK(ub)NIYVLQELDNPGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSVNFKNIYVLQELDNPGAK 20 1 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 22476200.0 7782500.0 5025400.0 9668300.0 True False 7535448.797425115 7032068.427114794 7135882.187217203 1.0 0.9331983556862165 0.9469750746173944 22.84526200796053 -10.900781514730802 10.526009338028656 1.0054093916801925 0.9400867151518054 0.9618567704752413 0.00562432195185453 0.0007655758041636649 7.216333809865474e-06 0.0058392843180227715 0.0018152421044367877 1.2566620073806787e-11 10.900781514730802 -0.06532267652838708 NSVNFK(ub)NIYVLQELDNPGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSVNFKNIYVLQELDNPGAK 20 1 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 37080600.0 4301700.0 8729900.0 24049000.0 True False 6525993.3963951105 7171981.137979974 19295704.608948827 1.0 1.098986882509213 2.956745959872955 22.63776609690215 -6.917919943189176 0.8400054675988834 0.955856647156048 3.242451436663742 0.9935834183359749 0.07209282533221173 0.09941129142112036 0.1120689135373353 0.06144063725626631 0.1805393850384041 1.2080365011558098e-07 6.917919943189176 2.286594789507694 up NSVNFK(ub)NIYVLQELDNPGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSVNFKNIYVLQELDNPGAK 20 1 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 13311200.0 2079800.0 3574800.0 7656600.0 True False 2848758.264481669 3416853.515717236 5848268.772626824 1.0 1.199418553100339 2.0529185805419385 21.441901774197607 -6.943324366403318 0.627884324639742 0.9906887233563977 2.3074801172889883 0.9985676132859055 0.01728326070492727 0.08628242190870171 0.047947094231310466 0.017282484978367547 0.07245243321414431 1.1393984743347986e-07 6.943324366403318 1.3167913939325906 up NSVNFK(ub)NIYVLQELDNPGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSVNFKNIYVLQELDNPGAK 20 1 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 25418300.0 7782500.0 7073800.0 10562000.0 True False 6471493.5732075265 7035692.035360629 12770465.366829693 1.0 1.0871821096275096 1.9733412731336684 22.625667283394808 -6.925930426147691 0.7794669601044981 0.9842994231700781 2.137748008936058 0.9956763086699718 0.02891443071921526 0.09480652069052305 0.08843894384349082 0.02573059431185902 0.08204920218449128 1.1859587231994642e-07 6.925930426147691 1.1534485857659798 NSVNFK(ub)NIYVLQELDNPGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSVNFKNIYVLQELDNPGAK 20 1 P12956;B1AHC9 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 64204600.0 4301700.0 6500900.0 53402000.0 True False 5568635.4491839465 6139119.200249631 43683383.95079185 1.0 1.1024458785768219 7.844540076185704 22.4088924189946 -6.91020546715975 0.8943354355798846 0.7926053803420312 8.719679649674326 0.9909988478360159 0.3038517336307296 0.10428229226737969 0.13803181903186754 0.24902046047740345 0.6883907485225691 1.2296868614070154e-07 6.91020546715975 7.927074269332294 up NSVSQISVLSGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSVSQISVLSGGK 13 0 O15143 O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 11897800.0 4619000.0 7278800.0 0.0 False True 6326769.123781526 6957198.548227198 0.0 1.0 1.0996447652998695 0.0 22.593037519364888 -6.96039402164146 1.1858626000240082 1.0588697895386099 4.495875352440005e-20 0.9750391158185612 0.07845160444269499 0.10354929447393658 0.2885990748016234 0.055189728591257925 0.10400898452240458 1.0954838473094735e-07 6.96039402164146 -1.0588697895386099 down NSVVEASEAAYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSVVEASEAAYK 12 0 Q04917;A2IDB2 Q04917 YWHAH 14-3-3 protein eta 0 6294100.0 1033700.0 2746400.0 2514000.0 False True 1355190.7103650407 2336647.8253833517 2253875.3959908313 1.0 1.7242206631965038 1.6631425959108859 20.370064459676417 -10.181603340568461 4.293332542164317 0.9997886994480404 1.6936816295905373 0.9942191248551875 0.024935016686893616 8248241.42835123 6.950717813199608 17333.334979620726 0.008997649101993844 6.582587783323332e-11 10.181603340568461 0.6938929301424969 NSVVEASEAAYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSVVEASEAAYK 12 0 Q04917;A2IDB2 Q04917 YWHAH 14-3-3 protein eta 0 6276100.0 1033700.0 2114000.0 3128400.0 False True 1415886.8246921343 2020596.4899368472 2389536.3514204375 1.0 1.4270889838784955 1.6876605599744954 20.43327452119931 -9.503591140288448 0.1023049011181471 4.396196287456385e-16 2.423653834503925 0.9999425465931664 0.0021486127653696156 0.9810654574507068 0.040932558222229666 0.6124545838139523 0.3456043914303839 3.136236895844972e-10 9.503591140288448 2.4236538345039245 NSWGTGWGENGYFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSWGTGWGENGYFR 14 0 P53634 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 8309500.0 2439100.0 2543600.0 3326800.0 False True 3197683.7202779967 2164104.794875146 2982574.6489189793 1.0 0.6767726217422796 0.9327297224566298 21.608595819664753 -9.879589804329383 6.013919180355531 1.0000000356886787 0.8047511734584628 0.43689134675106134 0.10449404879911636 5.0053264422479874e-08 9.27559147518263e-09 0.10117594729329892 0.03372530923133889 1.319502433997359e-10 9.879589804329383 -0.19524886223021587 NSWGTGWGENGYFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSWGTGWGENGYFR 14 0 P53634 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 6604400.0 2439100.0 1781700.0 2383600.0 False True 3340901.1841990706 1702978.6027059956 1820642.771782944 1.0 0.5097362983258238 0.5449555887476555 21.671805881187645 -10.103222161435458 5.553550955683473 1.0000049458599325 0.5273459435366253 0.9958530289202545 0.01437821510646594 8.804805178257016e-07 1.4217323140235002e-07 0.013921792486447735 0.004640548971235714 7.884566828852897e-11 10.103222161435458 -0.47265900232330715 NSYLEVLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSYLEVLLK 9 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 64237000.0 15887000.0 27064000.0 21286000.0 False True 20828010.849926867 23026156.694645714 19083528.90972986 1.0 1.105537963301309 0.9162434688186687 24.31202172759505 -6.755383679042557 1.629766902187625 1.0616527925317487 0.9157034845780874 0.6718704414880003 0.04436508179714533 0.29074435946677873 1.520893706415124 0.021489359410295356 0.051882090038652386 1.756371255755488e-07 6.755383679042557 -0.14594930795366134 NSYLEVLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NSYLEVLLK 9 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 108702000.0 47570000.0 23996000.0 37136000.0 False True 46059916.388501465 33577727.93748692 27408967.543880325 1.0 0.7290010614493725 0.5950720212493217 25.457008456453806 -13.999999998945242 0.09204619550714212 2.3757983214435603 0.2710752233230706 0.9998327294771061 0.0021784611773210455 12.145579877944188 0.08864568524074704 3.2474719211454786 0.2905849864451498 1.0000000024286702e-14 13.999999998945242 -2.10472309812049 NSYLEVLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NSYLEVLLK 9 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 200996000.0 39822000.0 98171000.0 63003000.0 False True 60412885.378163554 80651618.036476 50550429.43480407 1.0 1.3350068868855551 0.8367491325464103 25.84835295694986 -6.725549171794794 1.7393509481236618 1.2025959839179314 0.8372720040171676 0.5385747813311776 0.1408847975622324 0.34463958637033376 2.0404843046507986 0.06424240719249331 0.16022928496322963 1.881268692701045e-07 6.725549171794794 -0.3653239799007638 NSYLEVLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSYLEVLLK 9 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 82057000.0 15887000.0 22719000.0 43451000.0 False True 21760853.230031867 21715199.458313737 33188768.70143504 1.0 0.9979020229016056 1.5251593469520606 24.37523178911794 -6.906004176594552 0.9225228422153076 0.9815409846894486 1.5877797040377168 0.9893240026959671 0.02563057044072015 0.10712016808049452 0.1535420586998694 0.02057798208408825 0.05534808542827731 1.2416403667238462e-07 6.906004176594552 0.6062387193482682 NSYLEVLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NSYLEVLLK 9 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 79608000.0 47570000.0 14639000.0 17399000.0 False True 39556562.70831763 14560136.801386012 21037050.45611337 1.0 0.3680839740487468 0.5318220041320696 25.237413731888083 -10.539157524034286 9.598967285677324 1.0000207390070044 0.44995298909113207 0.9376816174258242 0.0668457708654371 2.9669123799650314e-05 1.424431381005146e-06 0.06472556580519472 0.02157437977718623 2.8896315867849342e-11 10.539157524034286 -0.5500677499158724 NSYLEVLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NSYLEVLLK 9 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 160186000.0 39822000.0 64264000.0 56100000.0 False True 51550364.008973934 60687651.90740385 45890375.634609625 1.0 1.1772497260511932 0.8902046865589734 25.61947927904231 -6.739643560127992 1.6878681395651918 1.1055044426279061 0.8900446107187097 0.6034192904540375 0.07447337721942454 0.3184509335584095 1.7812009384989684 0.034906527051671 0.08569542428935067 1.8211949604475245e-07 6.739643560127992 -0.2154598319091965 NSYVAGQYDDAASYQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NSYVAGQYDDAASYQR 16 0 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 12126200.0 2053800.0 6652700.0 3419700.0 False True 2692551.6890274943 5660143.09202149 3065862.2480787034 1.0 2.1021483506100647 1.1386456425599922 21.360542609836592 -6.613622908568687 2.139837002903798 1.734521441617249 1.1421467809860464 0.06196581183315708 0.4747283372649735 0.6026930850097492 5.234487846880751 0.1828468395555643 0.526904723001279 2.4343167727034343e-07 6.613622908568687 -0.5923746606312026 NSYVAGQYDDAASYQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NSYVAGQYDDAASYQR 16 0 P11413;P11413-3;P11413-2;E7EUI8;E9PD92;E7EM57 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 7625200.0 2053800.0 3003500.0 2567900.0 False True 2813145.3618580885 2870795.438753699 1961414.9075605902 1.0 1.0204931027302238 0.6972319788925061 21.423752671359484 -6.891781851990196 1.0117463274256953 1.0166344726829761 0.6684343023550146 0.982015712002952 0.019819918352217008 0.11771074114558296 0.2134808130646564 0.014889987588420592 0.03736851800340414 1.2829748646920958e-07 6.891781851990196 -0.3482001703279616 NTAELQPESGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTAELQPESGKR 12 1 O15355 O15355 PPM1G Protein phosphatase 1G 1 6557060.0 1974400.0 1150900.0 3431760.0 True False 2588457.5201167986 979190.2061730629 3076674.3949663914 1.0 0.37829100866560833 1.1886130527757561 21.303661211255015 -6.701708981970981 1.8246147490424656 0.6145953718358702 1.1862941502914142 0.42575784201828937 0.2623495957469083 0.39198241718575916 2.538230935896523 0.11465216876763064 0.2942522426271017 1.9874262332022835e-07 6.701708981970981 0.571698778455544 NTAELQPESGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTAELQPESGKR 12 1 O15355 O15355 PPM1G Protein phosphatase 1G 1 13708900.0 5698000.0 4561700.0 3449200.0 True False 5517120.108927517 6383210.598951238 2545751.046218006 1.0 1.1569823518292195 0.46142751942242544 22.395483957927844 -6.847427520084311 1.247560135346481 1.083618282267788 0.43498969395402054 0.9364595132953971 0.07508298923115357 0.16031164900699152 0.4814578990007587 0.04712520914265652 0.10887867527234557 1.4209293336367674e-07 6.847427520084311 -0.6486285883137675 down NTAELQPESGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 NTAELQPESGKR 12 1 O15355 O15355 PPM1G Protein phosphatase 1G 1 13677000.0 2189100.0 1470200.0 10017700.0 True False 3321024.744647129 1207831.3232749698 8037697.204086111 1.0 0.3636923588786166 2.420246105374968 21.663197041591687 -6.823609094457463 1.3561804030683318 0.6582294731750231 2.468717275199654 0.8924859175638846 0.281882390410452 0.18883203843369167 0.6814257220199463 0.1632911259831573 0.3760480787460329 1.501035299418018e-07 6.823609094457463 1.8104878020246309 up NTAELQPESGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTAELQPESGKR 12 1 O15355 O15355 PPM1G Protein phosphatase 1G 1 6094200.0 1974400.0 2782700.0 1337100.0 True False 2704389.0361537663 2659751.1128416588 1021304.5184389036 1.0 0.9834942670172956 0.3776470414520769 21.366871272777907 -6.912738422200681 0.8768792275984347 1.0171731300539866 0.2945860963594339 0.9919145186368381 0.026037750274153705 0.10263515276841971 0.1291510658634053 0.021610345673574536 0.060849248130004335 1.2225357780434522e-07 6.912738422200681 -0.7225870336945527 down NTAELQPESGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTAELQPESGKR 12 1 O15355 O15355 PPM1G Protein phosphatase 1G 1 13036050.0 5698000.0 4975000.0 2363050.0 True False 4738139.464200009 4948198.6875398215 2857152.8294912754 1.0 1.0443336936210845 0.6030115514916949 22.17588923336212 -6.88217255381939 1.067648694999982 1.0283502131875273 0.570407650031957 0.9753943697097758 0.031124349025509066 0.12572121129463176 0.26082619831401044 0.022411588193140555 0.05450697474620468 1.3116786395094134e-07 6.88217255381939 -0.45794256315557025 NTAELQPESGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NTAELQPESGKR 12 1 O15355 O15355 PPM1G Protein phosphatase 1G 1 6811500.0 2189100.0 4622400.0 0.0 True False 2833833.103612198 4365159.376583836 0.0 1.0 1.5403727802529035 0.0 21.434323363684136 -6.830648912068432 1.451377461125984 1.2925697890693364 1.5401900137443497e-21 0.8641052162652902 0.2352352369383837 0.1940769986076289 0.8199517073592031 0.12968771724360376 0.2808124831020859 1.4768999912913466e-07 6.830648912068432 -1.2925697890693364 down NTAEWLLSHTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTAEWLLSHTK 11 0 P00491;G3V5M2;G3V2H3 P00491 PNP Purine nucleoside phosphorylase 0 8322900.0 2164700.0 2292400.0 3865800.0 False True 2837942.6629846185 1950382.855705214 3465804.0993720647 1.0 0.6872523822077603 1.2212382387342295 21.43641401120207 -6.7480057017900075 1.657653659521401 0.8156569590040847 1.2221126320698605 0.6401714910974503 0.13140663366312003 0.3035351736909747 1.6404559306422537 0.06264443529551399 0.15237807529021424 1.7864641204666946e-07 6.7480057017900075 0.4064556730657758 NTAEWLLSHTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTAEWLLSHTK 11 0 P00491;G3V5M2;G3V2H3 P00491 PNP Purine nucleoside phosphorylase 0 7687000.0 2398600.0 1561900.0 3726500.0 False True 2322457.7559272572 2185574.8152008997 2750417.8573963246 1.0 0.9410611709181741 1.1842703491061783 21.147220924438656 -6.842679042237616 1.2698869721649024 0.9686486502920859 1.1927038636752918 0.9289652657375108 0.027609454930084966 0.1656918434237895 0.5178689863279506 0.017040275694884123 0.03929046225484342 1.436550698889806e-07 6.842679042237616 0.2240552133832059 NTAEWLLSHTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTAEWLLSHTK 11 0 P00491;G3V5M2;G3V2H3 P00491 PNP Purine nucleoside phosphorylase 0 7249700.0 2164700.0 1826100.0 3258900.0 False True 2965048.0888178963 1745416.8638948305 2489214.939152303 1.0 0.5886639311103694 0.8395192471042525 21.499624072724963 -10.365478196793964 5.807134946442805 1.00005908444957 0.7140915891073104 0.6339667703774561 0.10241125390827707 7.835628753123383e-05 8.561615152980271e-06 0.09917969980520246 0.03305309007091439 4.310441974914114e-11 10.365478196793964 -0.2859674953422596 NTCTSVYTK(ub)DR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NTCTSVYTKDR 11 1 P78527;P78527-2;F5GX40 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 49551500.0 2600400.0 7267100.0 39684000.0 True False 3944996.9147048527 5970229.226888538 31840440.005884923 1.0 1.5133672740363104 8.071093766182852 21.91159274126335 -6.922511697752126 0.8058768301947229 0.8679850821615603 9.192201923591718 0.9948506968688159 0.23100351286173035 0.09671641595818889 0.09812013450849591 0.2017275894886899 0.6195773319119667 1.1953313289074892e-07 6.922511697752126 8.324216841430157 up NTCTSVYTK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NTCTSVYTKDR 11 1 P78527;P78527-2;F5GX40 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 42992100.0 2600400.0 5203700.0 35188000.0 True False 3366269.061547284 4914109.520580072 28784145.059369754 1.0 1.4598088954664048 8.550755906047304 21.6827190633558 -6.920090330164934 0.8240559440562231 0.8440509642213803 9.696616284052851 0.994205963514066 0.26307977627474505 0.09811877074119693 0.10533898071213615 0.22677825348353178 0.6798969975653658 1.2020143981654448e-07 6.920090330164934 8.85256531983147 up NTDEMVELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTDEMVELR 9 0 P61978;P61978-2;S4R457;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 33900100.0 1685100.0 16562000.0 15653000.0 False True 2209182.418531615 14091014.158170344 14033377.714178402 1.0 6.378384166001226 6.352294675378603 21.075081120405365 -10.09111060071254 5.397612951456565 0.9999333615688651 6.365339420693077 0.999982266662182 0.010650989957070707 8.542046944713938e-06 1.4384745319799586e-06 0.010312897257330261 0.003437592225393218 8.107545586819307e-11 10.09111060071254 5.365406059124212 NTDEMVELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTDEMVELR 9 0 P61978;P61978-2;S4R457;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 26857900.0 7199600.0 4047300.0 15611000.0 False True 6971052.638861797 5663407.99639067 11522010.780038644 1.0 0.8124179072782567 1.652836576761226 22.73294509087007 -6.848145038901778 1.2442122625734109 0.9000445056812373 1.685211839772644 0.9375311501641406 0.09002716392247442 0.15951361385713195 0.47615811156555904 0.05664869197028946 0.13092672289030657 1.4185836861031663e-07 6.848145038901778 0.7851673340914068 NTDEMVELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTDEMVELR 9 0 P61978;P61978-2;S4R457;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 37968100.0 1685100.0 18157000.0 18126000.0 False True 2308127.008115232 17354763.702830333 13845012.116688037 1.0 7.51898125268326 5.998375335503562 21.138291181928256 -10.468447367100179 6.707689237175362 0.9984338515953614 6.758678294093411 0.9503050761215345 0.6207847661578463 0.014534872990931966 0.0011518183475263855 0.6008819223742292 0.2003574217423836 3.40057715489904e-11 10.468447367100179 5.760244442498049 NTDEMVELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTDEMVELR 9 0 P61978;P61978-2;S4R457;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 9994700.0 7199600.0 1836100.0 959000.0 False True 5986786.396359135 1826208.5648626857 1159522.4660849888 1.0 0.305039873474239 0.19368028008985796 22.513350366304348 -13.999999999999998 0.2577118706935046 6.027328470656125 0.15207815797927632 0.9995577006190366 0.007503061476269082 14.317167372880995 0.16064052229582818 37.43308253581794 0.049278806695030125 1.0000000000000041e-14 13.999999999999998 -5.875250312676849 NTDQASMPDNTAAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTDQASMPDNTAAQK 15 0 P35579;P35579-2;P35749-2;P35749;P35749-3;P35749-4;A0A494C024 P35579 MYH9;MYH11 Myosin-9;Myosin-11 0 7202140.0 2154300.0 782040.0 4265800.0 False True 2085912.9257042008 1094312.6502847252 3148459.0087431218 1.0 0.5246204847766055 1.5093913892307884 20.992247504613935 -6.775412476829633 1.5534732845041292 0.7292289935116583 1.5161380932749 0.750931332204717 0.2006806307759346 0.25775901090732833 1.228241120303098 0.10177639998910523 0.24111376659778397 1.6772103091260952e-07 6.775412476829633 0.7869090997632417 NTETEESLVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTETEESLVKR 11 1 B1ANH0;B1ANG9;B1ANH2;Q16774;Q16774-2;Q16774-3;B1ANH5;B1ANH6;B1ANH3 B1ANH0 GUK1 Guanylate kinase 1 2054390.0 382700.0 634190.0 1037500.0 True False 370551.3979793888 887425.3742571599 765747.6256671639 1.0 2.394877955113048 2.0665085325349577 18.499314142385124 -10.50056470560245 4.997907973782943 0.996073386373491 2.2306932438240477 0.9493130121254044 0.1340562554082714 0.005871974720822672 0.0005867793425121909 0.1299456272526353 0.04326647038757399 3.1581684773561517e-11 10.50056470560245 1.2346198574505567 NTETEESLVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTETEESLVKR 11 1 B1ANH0;B1ANG9;B1ANH2;Q16774;Q16774-2;Q16774-3;B1ANH5;B1ANH6;B1ANH3 B1ANH0 GUK1 Guanylate kinase 1 2260740.0 382700.0 1063900.0 814140.0 True False 318232.00648461573 1058168.5595323832 984372.909841953 1.0 3.3251481245445946 3.093255517306178 18.2797194178194 -9.889555137369886 6.938684015462552 0.9999999569270235 3.2092018209254056 0.9918042209971708 0.09466976047636143 6.408527928842949e-08 1.023630671789118e-08 0.09166360416030944 0.030554533809522378 1.289569825672758e-10 9.889555137369886 2.2092018639983824 NTEYK(ub)GEYWAEHPTIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTEYKGEYWAEHPTIK 16 1 Q5GLZ8-6;Q5GLZ8-3;Q5GLZ8-2;Q5GLZ8 Q5GLZ8-6 HERC4 Probable E3 ubiquitin-protein ligase HERC4 1 11211100.0 1754300.0 1899600.0 7557200.0 True False 2299904.288665366 1616187.0845828068 6775253.437781205 1.0 0.7027192794708339 2.945884953200763 21.133142393476014 -6.873520892052527 1.115362392367235 0.8277163675740429 3.086319166973066 0.9680696683649797 0.17776134159346985 0.13352074365980468 0.3083249603603278 0.12340902398069749 0.29408538575473 1.3380708447326864e-07 6.873520892052527 2.258602799399023 up NTEYK(ub)GEYWAEHPTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTEYKGEYWAEHPTIK 16 1 Q5GLZ8-6;Q5GLZ8-3;Q5GLZ8-2;Q5GLZ8 Q5GLZ8-6 HERC4 Probable E3 ubiquitin-protein ligase HERC4 1 19968690.0 814390.0 2418600.0 16735700.0 True False 788537.635224548 3384359.5928323762 12352118.109761901 1.0 4.291944279702805 15.664589181269006 19.588820087862334 -6.948242911752387 0.5778120412391163 0.8629144829022132 19.65401781387105 0.9990560828506659 0.19301759942645932 0.08419907286909716 0.038942233313427846 0.20271394028905254 0.9494618665723955 1.126567162766781e-07 6.948242911752387 18.791103330968838 NTEYK(ub)GEYWAEHPTIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NTEYKGEYWAEHPTIK 16 1 Q5GLZ8-6;Q5GLZ8-3;Q5GLZ8-2;Q5GLZ8 Q5GLZ8-6 HERC4 Probable E3 ubiquitin-protein ligase HERC4 1 43377700.0 6112800.0 22424900.0 14840000.0 True False 9273564.505540604 18423001.388456587 11906867.49539694 1.0 1.9866148962946817 1.2839580172524856 23.14469254744387 -10.043037439440003 4.459600034309045 0.999967755722292 1.6352864564362783 0.5215108905420851 0.28685846985491636 42330626.329736926 31776251.826269105 12507.927430643724 0.09819928604912595 9.05654523323717e-11 10.043037439440003 0.6353187007139863 NTEYK(ub)GEYWAEHPTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTEYKGEYWAEHPTIK 16 1 Q5GLZ8-6;Q5GLZ8-3;Q5GLZ8-2;Q5GLZ8 Q5GLZ8-6 HERC4 Probable E3 ubiquitin-protein ligase HERC4 1 15452900.0 1754300.0 1742200.0 11956400.0 True False 2402912.1181749147 1665223.8433150286 9132544.569787534 1.0 0.6930023910236954 3.800615303702401 21.196352454998905 -6.8826157885221155 1.0651536518393836 0.8022871275961493 4.032156751687394 0.97573279866955 0.21781241501758924 0.12533597167586563 0.25852540581883016 0.15713933067000865 0.382642223962691 1.310340642039553e-07 6.8826157885221155 3.2298696240912443 up NTEYK(ub)GEYWAEHPTIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTEYKGEYWAEHPTIK 16 1 Q5GLZ8-6;Q5GLZ8-3;Q5GLZ8-2;Q5GLZ8 Q5GLZ8-6 HERC4 Probable E3 ubiquitin-protein ligase HERC4 1 15579990.0 814390.0 2477900.0 12287700.0 True False 677201.3685942156 2464551.060875357 14857001.258094402 1.0 3.6393178974098257 21.93882343878846 19.36922536329661 -6.932858304021504 0.7229481380524162 0.7490811502368985 25.984493047867485 0.9970707427807224 0.503942022631928 0.09118066529847545 0.07060775165821372 0.46718468650870915 1.6305479299301229 1.1671903707003957e-07 6.932858304021504 25.235411897630588 NTEYK(ub)GEYWAEHPTIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NTEYKGEYWAEHPTIK 16 1 Q5GLZ8-6;Q5GLZ8-3;Q5GLZ8-2;Q5GLZ8 Q5GLZ8-6 HERC4 Probable E3 ubiquitin-protein ligase HERC4 1 48802900.0 6112800.0 19138900.0 23551200.0 True False 7913140.101302187 18073803.390554797 19265123.255718675 1.0 2.2840241875131935 2.434573760743653 22.91581886953632 -10.624042365056471 0.42174244837816766 2.804505217516799e-14 2.4426188284915917 0.9994289863694908 0.015382275015017497 2.137429604538305 0.20128131379186506 2.275079458631806 0.03623804244654688 2.376608439189628e-11 10.624042365056471 2.4426188284915638 NTFAEVTGLSPGVTYYFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTFAEVTGLSPGVTYYFK 18 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 11057400.0 3354300.0 4388000.0 3315100.0 False True 4397519.783087407 3733327.504290035 2972085.2526846537 1.0 0.8489620714494986 0.6758548907761853 22.06825863727676 -6.969343432967428 0.27341757428844804 1.04128888215638 0.478300071459833 0.9999767954735521 0.0006379221570563844 0.0765163813391694 0.009790332326751349 0.0033237220245349685 0.016025487017233612 1.0731404548089371e-07 6.969343432967428 -0.5629888106965469 NTFAEVTGLSPGVTYYFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTFAEVTGLSPGVTYYFK 18 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 35364600.0 17283000.0 9455800.0 8625800.0 False True 16734360.625235919 13231550.251345579 6366444.211546825 1.0 0.7906815532224161 0.3804414374784081 23.99631009480438 -6.960439142868838 0.4291993774234342 1.0164344156373923 0.1389772932132263 0.9997861421066054 0.0037631443818859516 0.0795446177220753 0.020554386032020457 0.00534537946124982 0.03406900591108298 1.0953700374174372e-07 6.960439142868838 -0.8774571224241661 down NTFAEVTGLSPGVTYYFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTFAEVTGLSPGVTYYFK 18 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 17844500.0 3354300.0 4897600.0 9592600.0 False True 4594475.356549118 4681207.837802603 7327025.445798394 1.0 1.0188775593561197 1.5947469247722068 22.13146869879965 -6.913874549052886 0.8689382516848311 0.9842795428581146 1.6756808818480295 0.9923032426715446 0.024215951556753202 0.1019114413122401 0.12528389101408305 0.020213809002115647 0.057416884168728 1.2193417689271287e-07 6.913874549052886 0.691401338989915 NTFAEVTGLSPGVTYYFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTFAEVTGLSPGVTYYFK 18 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 30723200.0 17283000.0 8122800.0 5317400.0 False True 14371580.26671968 8079040.864150429 6429243.755120261 1.0 0.562153967358697 0.44735816352836877 23.776715370238655 -13.999999999999998 0.18793176513235382 3.3305933762594897 0.3632665181253775 0.9994906791481931 0.005373869339148995 12.317767800520414 0.13747137071180734 10.505434496708869 0.08026464397667306 1.0000000000000041e-14 13.999999999999998 -2.967326858134112 NTFPK(ub)WKPGSLASHVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTFPKWKPGSLASHVK 16 2 P06493;A0A024QZP7;P06493-2 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 15480400.0 1879700.0 2826700.0 10774000.0 True False 1820029.9523957619 3955416.05104577 7951966.18692822 1.0 2.173269756269194 4.369140286103973 20.795530762504878 -6.961321730306582 0.41638803517467204 0.8990806799812634 5.725674425386221 0.9998161206709266 0.018935542268552735 0.07923231463271313 0.019411463150801896 0.02834676555644762 0.1829777715592291 1.093146251024572e-07 6.961321730306582 4.826593745404958 NTFPK(ub)WKPGSLASHVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTFPKWKPGSLASHVK 16 2 P06493;A0A024QZP7;P06493-2 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 1 11796700.0 1879700.0 4425400.0 5491600.0 True False 1563053.8348291952 4401559.491826874 6639868.169710464 1.0 2.815999931510907 4.248009903277608 20.575936037939154 -7.625331121686195 0.2102484139308442 1.7012634790783215e-18 6.15929729095067 0.9999054633205778 0.012922637652107405 0.13728883793395813 0.02500167107936688 0.2159209671660073 0.4079600385532612 2.3695663743889528e-08 7.625331121686195 6.15929729095067 NTGDIQK(ub)YLTPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTGDIQKYLTPK 12 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 23951200.0 6165000.0 11921900.0 5864300.0 True False 8082374.701944924 10143198.991202211 5257518.490337732 1.0 1.2549775734551598 0.6504918027461131 22.94634780628316 -6.792117354093462 1.487925132827762 1.1421148543180495 0.6436879793026049 0.8080973190566201 0.10854602770544364 0.2322071416809916 1.0155478475480395 0.057415204343378434 0.13421506855570048 1.6139223873641419e-07 6.792117354093462 -0.4984268750154446 NTGDIQK(ub)YLTPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTGDIQKYLTPK 12 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 43447700.0 12525700.0 12988300.0 17933700.0 True False 12128078.509721523 18174595.9230897 13236325.970532272 1.0 1.4985552664852444 1.091378651607706 23.531847661983846 -9.927852106730867 5.718854683208155 0.9999997820709841 1.2949669590467965 0.4116653142811302 0.16622915694175436 4.618980984834794e-07 8.639164585476369e-08 0.16095080663985636 0.05365022970729387 1.1807226467533833e-10 9.927852106730867 0.29496717697581243 NTGDIQK(ub)YLTPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTGDIQKYLTPK 12 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 18886600.0 6165000.0 8419200.0 4302400.0 True False 8444367.102860598 8047211.905428708 3286261.7307094005 1.0 0.9529680327022554 0.38916613769623454 23.009557867806052 -6.92340869441161 0.7990395053133491 1.0109790144816926 0.29071608721170944 0.9950765597270367 0.019473461288191208 0.0962075241523804 0.09552426690471522 0.017088685011879382 0.05298287694085142 1.192865026110232e-07 6.92340869441161 -0.7202629272699832 down NTGDIQK(ub)YLTPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTGDIQKYLTPK 12 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 25471000.0 12525700.0 11334600.0 1610700.0 True False 10415674.532595633 11273538.260058057 1947489.9229646465 1.0 1.0823627624670642 0.18697684118969138 23.312252937418123 -6.8844056505334965 1.0548882843470964 1.0547576065558137 0.11789771902143129 0.9770702199237614 0.06118773875745294 0.1238006247979266 0.24929215409683156 0.04448842076006323 0.10889890231720134 1.304951435513008e-07 6.8844056505334965 -0.9368598875343824 down NTGEIK(ub)ALAGCDFLTISPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTGEIKALAGCDFLTISPK 19 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 8025800.0 1724300.0 3195000.0 3106500.0 True False 2260573.998144956 2718318.454012457 2785069.179652155 1.0 1.2024903658288246 1.2320185855174852 21.108257713262617 -13.192026883626689 0.2820362505300446 2.786086185451418e-07 1.240964099099809 0.9995619192554168 0.002158369881399977 9.933087860398498 0.16545054623671523 5.664873779609796 0.011573542210330152 6.426479349973321e-14 13.192026883626689 1.2409638204911904 NTGEIK(ub)ALAGCDFLTISPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTGEIKALAGCDFLTISPK 19 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 6555100.0 1724300.0 2161500.0 2669300.0 True False 2361820.3074554014 2065997.7828753495 2038866.3159591411 1.0 0.8747480815342943 0.8632605577669 21.17146777478551 -13.999999999999979 0.33805365500292933 2.431591971481167 0.8614130547143559 0.9997312961712691 0.001015148222161666 19.52632873297272 0.18638268168199987 19.956638943509308 0.003574000558990641 1.000000000000049e-14 13.999999999999979 -1.5701789167668112 NTGEIK(ub)ALAGCDFLTISPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTGEIKALAGCDFLTISPK 19 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 5485300.0 0.0 1809500.0 3675800.0 True False 0.0 1799751.8643423726 4444392.785021072 0.0 NTGEIK(ub)ALAGCDFLTISPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NTGEIKALAGCDFLTISPK 19 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 29720300.0 8157900.0 5225400.0 16337000.0 True False 10560562.366250027 4934601.8965042345 13363833.63177571 1.0 0.46726696224762443 1.2654471578601267 23.332183326691766 -6.726821639447919 1.734924438621338 0.6782741291411888 1.2646949294189027 0.5444412958901614 0.22400940105400052 0.34221962022374525 2.016510795077199 0.10238586251069216 0.2549726902450779 1.8757647083612737e-07 6.726821639447919 0.5864208002777139 NTGIICTIGPASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTGIICTIGPASR 13 0 P14618;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 421985000.0 47885000.0 197650000.0 176450000.0 False True 62777698.71899966 168161390.43366566 158192646.6279169 1.0 2.6786803891358897 2.5198860400411576 25.903748808334836 -9.62096839865008 9.072896455851328 0.9999993277801165 2.599283214599681 0.9926602506831764 0.06482752155440927 0.0 0.0 0.06276897783850682 0.020922992612835603 2.393489911877263e-10 9.62096839865008 1.5992838868195645 NTGIICTIGPASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTGIICTIGPASR 13 0 P14618;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 135301000.0 65900000.0 26599000.0 42802000.0 False True 63808040.57183625 37220119.41195253 31590872.167523835 1.0 0.583313937842198 0.4950923407835766 25.927234896386768 -13.999999999999998 0.2181999526917173 3.4948032077835345 0.4470807140417646 0.999496154108623 0.004942433710129503 12.95132615612041 0.1479950609182804 13.909276920399693 0.04941038708871997 1.0000000000000041e-14 13.999999999999998 -3.04772249374177 NTGIICTIGPASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTGIICTIGPASR 13 0 P14618;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 379475000.0 47885000.0 136790000.0 194800000.0 False True 65589378.54346796 130746165.49596067 148792252.03193375 1.0 1.9934045481054747 2.268541878824555 25.966958869857727 -10.492134311933226 0.27386298292833716 1.1440777234641694e-10 2.3820978919069424 0.9991005338720901 0.01634064396728499 2.093221157272906 0.13400715532192484 1.558169959641439 0.11079445369778386 3.220072782577221e-11 10.492134311933226 2.382097891792535 NTGIICTIGPASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTGIICTIGPASR 13 0 P14618;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 90759500.0 65900000.0 7131500.0 17728000.0 False True 54798769.86500179 7093081.194008075 21434842.834989246 1.0 0.12943869381524561 0.3911555476116443 25.707640171821044 -10.217003464887537 5.383420377764513 1.0000450669126002 0.2602971209366984 0.9141703829242819 0.10684545814831123 5.779614780637439e-05 8.40637561403934e-06 0.10345893907484151 0.0344842233354752 6.067314889450071e-11 10.217003464887537 -0.7397479459759018 NTGIICTIGPASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NTGIICTIGPASR 13 0 P14618;P14618-2;B4DNK4;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25;H3BU13 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 167065000.0 46021000.0 54520000.0 66524000.0 False True 59575091.70953216 51485914.07306828 54417314.59388183 1.0 0.8642187967430425 0.9134239332639572 25.828205931504723 -10.389630631312839 7.759693673820089 1.0000020405253522 0.888821365475043 0.8719110442784379 0.020087912866704437 7.091399331892233e-07 5.578496372780255e-08 0.01945039490174219 0.006483345999400997 4.0772690326651744e-11 10.389630631312839 -0.11118067505030926 NTGK(ub)SLISTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTGKSLISTK 10 1 Q8IWI9-3;Q8IWI9;H3BP52;H3BTF4 Q8IWI9-3 MGA MAX gene-associated protein 1 2649050.0 645840.0 1186900.0 816310.0 True False 625338.1627149421 1660835.3596017319 602493.9222249276 1.0 2.6558995734261894 0.9634689807018415 19.25427703819084 -6.6511482682179235 2.0042770659174804 2.073530853978949 0.9705638065296726 0.1987761820990459 0.7065558193524709 0.5057290669638548 3.8953339602633035 0.28575955236342976 0.7827256528027569 2.2328098110041277e-07 6.6511482682179235 -1.1029670474492765 NTGSGLLGMANIDLEK(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTGSGLLGMANIDLEKSR 18 1 Q02223 Q02223 TNFRSF17 Tumor necrosis factor receptor superfamily member 17 1 48644000.0 6994000.0 10697000.0 30953000.0 True False 9169201.729992343 9101049.296579419 27750280.48214173 1.0 0.9925672446282866 3.0264663489048247 23.128364707690675 -6.906076799405683 0.9220430990493236 0.9289497574685517 3.2683922926540383 0.9893548006985499 0.09874337157980975 0.10706967348584065 0.1532650408761302 0.0793060246402207 0.21340197142474826 1.2414327567292887e-07 6.906076799405683 2.3394425351854866 up NTGSGLLGMANIDLEK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTGSGLLGMANIDLEKSR 18 1 Q02223 Q02223 TNFRSF17 Tumor necrosis factor receptor superfamily member 17 1 95553800.0 16868000.0 17928400.0 60757400.0 True False 16332534.573076395 25087303.61537086 44843214.25707005 1.0 1.5360324818614737 2.745637185485742 23.961245357883126 -6.957617956861377 0.46780477619227895 0.9673598935225934 3.3637141061885596 0.9996713699957296 0.013235791580444333 0.0805633792016141 0.02436118283964442 0.016656586498905668 0.09985177335038087 1.1025087455087298e-07 6.957617956861377 2.3963542126659663 NTGSGLLGMANIDLEK(ub)SR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTGSGLLGMANIDLEKSR 18 1 Q02223 Q02223 TNFRSF17 Tumor necrosis factor receptor superfamily member 17 1 71535200.0 6994000.0 13950000.0 50591200.0 True False 9579870.80574323 13333642.873518938 38642600.51847001 1.0 1.391839529352033 4.033728773805945 23.191574769213567 -6.933420513802158 0.7181659889381664 0.9644732016840695 4.626560437817889 0.9971686950321692 0.07168912333996137 0.09090062219040157 0.0692634173904591 0.06669527008096066 0.23471255994209667 1.1656803784904027e-07 6.933420513802158 3.6620872361338197 up NTGSGLLGMANIDLEK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTGSGLLGMANIDLEKSR 18 1 Q02223 Q02223 TNFRSF17 Tumor necrosis factor receptor superfamily member 17 1 72294000.0 16868000.0 14171000.0 41255000.0 True False 14026489.379102439 14094658.010276744 49881229.75843194 1.0 1.004859992356738 3.5562162712466163 23.741650633317402 -6.907315615852936 0.9138279065514135 0.9141428930551908 3.867676106923919 0.9898683249381947 0.12117680777432832 0.1062198797239301 0.14859700266687015 0.0979106384600359 0.26550333057403835 1.2378966400155883e-07 6.907315615852936 2.9535332138687282 up NTHATTHNAYDLEVIDIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTHATTHNAYDLEVIDIFK 19 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 8794400.0 1395200.0 4701500.0 2697700.0 False True 1829120.711136021 4000054.526303466 2418567.882165662 1.0 2.1868729067198265 1.3222571191944736 20.802718856882525 -10.228776435086488 4.941261593335577 0.9998833514665263 1.7545650129580141 0.5038485467581766 0.35297791716828225 0.000453662435665252 7.080697448675439e-05 0.34182161266269145 0.11392313289721787 5.905049804670362e-11 10.228776435086488 0.7546816614914879 NTHATTHNAYDLEVIDIFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTHATTHNAYDLEVIDIFK 19 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 13615600.0 4073300.0 3774100.0 5768200.0 False True 3943995.3211116972 5281117.811671492 4257335.377709243 1.0 1.3390274028476532 1.0794473702644314 21.911226409525558 -10.026381267063586 5.050689679637612 0.9999976687497384 1.2092373865517385 0.46418414610246317 0.1059731045456933 3.0194851170410343e-06 5.821575238538081e-07 0.1026092587149996 0.03420267242022477 9.410630746354922e-11 10.026381267063586 0.20923971780200012 NTHATTHNAYDLEVIDIFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTHATTHNAYDLEVIDIFK 19 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 7703100.0 1395200.0 3147000.0 3160900.0 False True 1911043.1438623061 3007955.134262652 2414360.5207789475 1.0 1.5739859897581572 1.2633731104047257 20.865928918405416 -10.181965921518223 4.877135648356529 0.999957123612826 1.4186795500825709 0.7078156995284834 0.12680717699599692 5.912533936418912e-05 9.916781862457613e-06 0.12279306607987123 0.04092684038986687 6.577094448726718e-11 10.181965921518223 0.4187224264697449 NTHPFLYLSLEISPQNVDVNVHPTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NTHPFLYLSLEISPQNVDVNVHPTK 25 0 A0A669KBB4;A0A669KBK2;H0Y818;A0A669KAW3;P40692;P40692-3;E7EUC9;P40692-2 A0A669KBB4 MLH1 DNA mismatch repair protein Mlh1 0 30364900.0 9726800.0 11027000.0 9611100.0 False True 14756266.724331304 9059145.695655769 7711461.8723052135 1.0 0.6139185381298597 0.5225889458605368 23.81482443577574 -13.999999999772726 0.20251032458367008 3.1669755911874744 0.46472112901190854 0.9994872092009253 0.004685544195297313 12.58165783646958 0.1426799375005422 10.810803086707718 0.057083951944236044 1.0000000005233182e-14 13.999999999772726 -2.7022544621755658 NTHTLLLAGVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTHTLLLAGVFR 12 0 Q9Y678;H0Y8X7 Q9Y678 COPG1 Coatomer subunit gamma-1 0 46931500.0 14793200.0 10196900.0 21941400.0 False True 19394028.457552604 8675562.267204897 19671114.404770587 1.0 0.44733162510269386 1.0142871785418093 24.209109170187702 -10.839649336114759 12.037192723529907 1.003161462558705 0.7308094018222518 0.23111243828516348 0.23145863546051218 0.019716984659301127 0.0002626545755834914 0.22501455077509475 0.0747029533728714 1.4466073384479959e-11 10.839649336114759 -0.27235206073645324 NTHTLLLAGVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTHTLLLAGVFR 12 0 Q9Y678;H0Y8X7 Q9Y678 COPG1 Coatomer subunit gamma-1 0 31935400.0 10726200.0 7231000.0 13978200.0 False True 10385702.652225042 10118376.00916686 10316890.082988685 1.0 0.9742601293326157 0.9933742981538554 23.308095490272578 -10.08944462930689 4.8002361703928385 1.0000006889258368 0.9838172137430564 0.48868142384903024 0.007803326745525569 5.753419642405848e-08 1.0907189794780605e-08 0.007555860305183214 0.002518512877448622 8.1387061919506e-11 10.08944462930689 -0.016183475182780405 NTHTLLLAGVFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NTHTLLLAGVFR 12 0 Q9Y678;H0Y8X7 Q9Y678 COPG1 Coatomer subunit gamma-1 0 33928300.0 8419300.0 12806000.0 12703000.0 False True 12772693.633277396 10520669.246265318 10192246.482077302 1.0 0.8236844590756678 0.7979715770777501 23.606559471286126 -13.999999999999998 0.2711459401574173 2.369279492531294 0.7895308815716909 0.9995857933769196 0.0018274484075633038 14.939536827021533 0.16484850553405703 11.283939045999185 0.010618331963003255 1.0000000000000041e-14 13.999999999999998 -1.5797486109596033 NTHTLLLAGVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTHTLLLAGVFR 12 0 Q9Y678;H0Y8X7 Q9Y678 COPG1 Coatomer subunit gamma-1 0 42947300.0 14793200.0 11992800.0 16161300.0 False True 20262645.811198305 11462918.441113815 12344333.792421406 1.0 0.5657167651214998 0.6092162843610096 24.272319231710593 -10.142801677748418 7.979121939693668 1.0000000596718897 0.5874665252238728 0.9917300042655292 0.017758604365529795 1.8857607496542744e-08 1.9909084978284466e-09 0.017194697302084328 0.005731564913298606 7.197775921824075e-11 10.142801677748418 -0.4125335344480169 NTHTLLLAGVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTHTLLLAGVFR 12 0 Q9Y678;H0Y8X7 Q9Y678 COPG1 Coatomer subunit gamma-1 0 23695300.0 10726200.0 4756400.0 8212700.0 False True 8919310.551228868 4730776.329128518 9929937.5987656 1.0 0.5303970864067212 1.113307754196034 23.088500765706854 -6.692295985073815 1.8580567734608624 0.706217393544198 1.1113579890370544 0.38116076007846467 0.19851894724623453 0.4118210936754892 2.7582456955130006 0.08541164783793294 0.2217927543103607 2.0309723688903455e-07 6.692295985073815 0.4051405954928564 NTHTLLLAGVFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NTHTLLLAGVFR 12 0 Q9Y678;H0Y8X7 Q9Y678 COPG1 Coatomer subunit gamma-1 0 43517400.0 8419300.0 26083200.0 9014900.0 False True 10898949.81921436 24631646.9910245 7374280.70068525 1.0 2.2600018717032726 0.6766047025636106 23.377685793378575 -6.694679161784403 1.8495871963859982 1.786434108726683 0.681713274854726 0.39252435385923745 0.53239440755678 0.40667560205678027 2.700777053541735 0.22995656315340007 0.595359598451697 2.0198579974614887e-07 6.694679161784403 -1.1047208338719572 NTISLLVAGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTISLLVAGLK 11 0 Q14204 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 11927700.0 1837300.0 5185800.0 4904600.0 False True 2408718.0924385074 4412098.854090082 4397119.040245282 1.0 1.8317207264480744 1.8255017280971153 21.199834125026022 -10.330436960028605 4.5518173372920065 0.9992576270146539 1.8286112272750472 0.9999577541141845 0.0025388954535315008 1.91432447128327e-05 2.8159279268455408e-06 0.002460325290713308 0.000819424982931501 4.672647720200041e-11 10.330436960028605 0.8293536002603933 NTISLLVAGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTISLLVAGLK 11 0 Q14204 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 5873300.0 1597700.0 1734600.0 2541000.0 False True 1546981.8880367656 2427234.8258195026 1875435.871633989 1.0 1.569013085796268 1.2123192172689596 20.561024875230384 -10.525286098772275 6.10222979575885 0.9995045584020831 1.3906661515326137 0.6152968866178803 0.14561966204521568 0.0009827254717228564 7.644938232738283e-05 0.1411675707802011 0.04699854383178934 2.983416595704839e-11 10.525286098772275 0.39116159313053067 NTISLLVAGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTISLLVAGLK 11 0 Q14204 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 8404400.0 1837300.0 2921100.0 3646000.0 False True 2516599.4611655744 2792036.143214059 2784889.8917270587 1.0 1.109447961941832 1.1066083159841513 21.263044186548914 -10.133856595101781 4.157447295901119 0.9999732856151969 1.1080281389790343 0.9994820334798885 0.0011592806858964847 809664.5606299766 0.013586682916700461 209.86340085628024 0.00039685260214527814 7.34756446139041e-11 10.133856595101781 0.10805485336383736 NTISLLVAGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTISLLVAGLK 11 0 Q14204 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 4644510.0 1597700.0 859610.0 2187200.0 False True 1328558.3401109776 854979.1103107753 2644533.4075298123 1.0 0.6435390035181721 1.9905286261715147 20.34143015066466 -6.836334589941475 1.2992798906445753 0.8101910300582881 2.031720587459019 0.9179722190119789 0.16320871868903303 0.17312287335386978 0.5692770801831217 0.09855323439880315 0.22687672444558188 1.4576907907785676e-07 6.836334589941475 1.2215295574007312 NTISLLVAGLKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTISLLVAGLKK 12 1 Q14204 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 3865430.0 1499400.0 758430.0 1607600.0 False True 2053768.699761426 724920.0548073803 1227917.9895612774 1.0 0.3529706411883626 0.5978852388313821 20.96984228043635 -10.262974539506818 5.591624641373472 1.0000396858264706 0.4754279400099141 0.8594861372171075 0.09998596579745513 4.947052552180727e-05 6.520708704117528e-06 0.096818292292845 0.03227033169899376 5.4578985705758657e-11 10.262974539506818 -0.5246117458165565 NTIVTSYNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTIVTSYNR 9 0 Q99798;A2A274 Q99798 ACO2 Aconitate hydratase, mitochondrial 0 4227620.0 726120.0 1830600.0 1670900.0 False True 951950.3517560826 1557481.61562291 1498011.2964045668 1.0 1.6360954253021611 1.5736233445800554 19.86052680727351 -10.261060463256158 4.692512162460122 0.9997938555437519 1.604859384942877 0.9920628684981866 0.025504120162582935 5.5021806497600136e-05 8.664359710632856e-06 0.02470254893079375 0.008231419386588171 5.482006381324189e-11 10.261060463256158 0.6050655293991251 NTIVTSYNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTIVTSYNR 9 0 Q99798;A2A274 Q99798 ACO2 Aconitate hydratase, mitochondrial 0 4210220.0 726120.0 1475500.0 2008600.0 False True 994586.1866551725 1410307.53117399 1534210.0484155137 1.0 1.4179842331381083 1.5425611867535731 19.9237368687964 -11.994108841534976 0.2019679774353714 3.5976763230075105e-15 1.6307079452242292 0.999400805378449 0.005680093291516023 5.232941206580739 0.1260362544645343 2.2687795441601613 0.07766895456953352 1.0136573142510677e-12 11.994108841534976 1.6307079452242257 NTK(ub)GGDAPAAGEDA ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTKGGDAPAAGEDA 14 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 45072000.0 15157000.0 17535000.0 12380000.0 True False 19870973.780596804 14918846.35089464 11099036.357345477 1.0 0.7507858706684161 0.5585552313587788 24.244159238058025 -6.974020199735626 0.13022898764759128 1.2967502559276005 0.007614776773967957 0.9999992136319256 0.0001601527550400841 0.07501836645354458 0.0039103805737569835 0.012064196068553456 0.026232183704095056 1.0616461771772681e-07 6.974020199735626 -1.2891354791536325 NTK(ub)GGDAPAAGEDA ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTKGGDAPAAGEDA 14 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 63860000.0 24439000.0 21197000.0 18224000.0 True False 23663197.322232235 29661072.640894733 13450587.691718934 1.0 1.2534685079529522 0.5684180167437362 24.496141685027073 -6.806526523374856 1.4290494576203352 1.1387152181470979 0.5573580765433791 0.8505766310039693 0.10931882982737234 0.21157293871460064 0.8521920802285253 0.06016141983432937 0.13939970490689604 1.5612536856614916e-07 6.806526523374856 -0.5813571416037188 NTK(ub)GGDAPAAGEDA ddPTM_RPMI8226_Bortezomib_8h_R1 1 NTKGGDAPAAGEDA 14 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 71137000.0 21913000.0 14089000.0 35135000.0 True False 33243623.054886717 11574707.872140562 28190551.849782452 1.0 0.3481782913080863 0.84799878169833 24.986574286947874 -9.993746870203703 6.836108629696036 1.0000000531220319 0.5980885365033232 0.46297979411870815 0.2040508607406305 1.652642109373099e-07 2.4117004823722377e-08 0.19757142285318605 0.06585713211897867 1.0145025191788683e-10 9.993746870203703 -0.4019115166187087 NTK(ub)GGDAPAAGEDA ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTKGGDAPAAGEDA 14 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 45208000.0 15157000.0 17155000.0 12896000.0 True False 20760952.502523627 16397035.376001244 9850230.40145696 1.0 0.7898016901685064 0.47445946423988017 24.307369299580916 -6.9652549165918165 0.35365098796373906 1.029221995174967 0.22433845613689396 0.9999183024785934 0.0019521412886092987 0.0778745682354625 0.014555589431297481 0.00429003872512481 0.02704017378002449 1.0832908712222533e-07 6.9652549165918165 -0.8048835390380731 down NTK(ub)GGDAPAAGEDA ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTKGGDAPAAGEDA 14 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 61333400.0 24439000.0 27318000.0 9576400.0 True False 20322111.33127128 27170832.511801578 11578780.9637292 1.0 1.3370083486350957 0.5697626971422006 24.27654696046135 -6.787352697705312 1.5073117188310359 1.189006230894416 0.5622336496989904 0.7924983964026237 0.1430328005577133 0.23932411115166258 1.0742776804711776 0.07470995478003832 0.1752262792292089 1.631726257877282e-07 6.787352697705312 -0.6267725811954257 NTK(ub)GGDAPAAGEDA ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NTKGGDAPAAGEDA 14 1 P62851 P62851 RPS25 40S ribosomal protein S25 1 68608000.0 21913000.0 16624000.0 30071000.0 True False 28366810.469806805 15698859.786329567 24598386.554515976 1.0 0.5534235088939305 0.8671537669241355 24.757700609040324 -10.175914189407692 5.648007923899961 1.000006419812437 0.7102886379090162 0.5320522830381746 0.1280798415076785 1.0353954079304602e-05 1.5106726008417904e-06 0.12401552032812352 0.041337591095334886 6.669385340400902e-11 10.175914189407692 -0.2897177819034208 NTK(ub)IEVLEEELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTKIEVLEEELR 12 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 7825800.0 1980000.0 3041700.0 2804100.0 True False 2595799.1743472754 2587890.2164537394 2513958.630826531 1.0 0.9969531703485788 0.9684719279020021 21.30774734195993 -6.92732460288109 0.768482181626002 1.0004787683315302 0.9630050829163437 0.9959849700358352 0.0008996855943946562 0.09405034578719154 0.08467425685233823 0.000806976214396589 0.002615980741052079 1.1821576503649776e-07 6.92732460288109 -0.037473685415186475 NTK(ub)IEVLEEELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTKIEVLEEELR 12 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 12109400.0 2042900.0 4778000.0 5288500.0 True False 1978049.2577269233 6685880.316940841 3903283.1984007657 1.0 3.3800373225406557 1.9732992912857117 20.915646922111556 -10.176489575893417 6.025793388017876 0.9999817129725102 2.6766683069131982 0.6544713567657501 0.5742983963903837 0.00014109146424577223 1.928321746143216e-05 0.556068060175301 0.1853540104144575 6.660555080322441e-11 10.176489575893417 1.676686593940688 NTK(ub)IEVLEEELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NTKIEVLEEELR 12 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 25013300.0 4081000.0 9307300.0 11625000.0 True False 6191175.361063874 7646339.596733184 9327313.654581493 1.0 1.2350384459824537 1.5065497438888102 22.561781892593984 -6.9692344963685615 0.2758566474306887 0.9371208968067077 1.812694324718825 0.9999757805550247 0.0010185832368401876 0.07655188561027351 0.00991584566070515 0.005137916574398966 0.02505438032605419 1.0734096706042992e-07 6.9692344963685615 0.8755734279121172 NTK(ub)IEVLEEELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTKIEVLEEELR 12 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 12010600.0 1980000.0 3430100.0 6600500.0 True False 2712059.5074880756 3278546.840176151 5041597.84156457 1.0 1.2088771765973376 1.8589554645259703 21.370957403482823 -6.950622061489326 0.5519731049125118 0.9911129776473564 2.1073628760510204 0.9992491937185117 0.010022183456673906 0.08323693093381901 0.034936153452300354 0.010850469349782206 0.053949869708160646 1.120412482147499e-07 6.950622061489326 1.116249898403664 NTK(ub)IEVLEEELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTKIEVLEEELR 12 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 9332100.0 2042900.0 5054200.0 2235000.0 True False 1698761.8658150553 5026972.021419852 2702328.1665275837 1.0 2.9591975912456348 1.5907633794398979 20.696052197545832 -10.086022570310927 4.895284098731348 0.9999572144921092 2.27498048535202 0.5364873901766778 0.5586609276139279 194169059.3933946 8.433006951445313 93647.92125712626 0.1912444950269824 8.203089117174393e-11 10.086022570310927 1.275023270859911 NTK(ub)IEVLEEELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NTKIEVLEEELR 12 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 17238600.0 4081000.0 6006900.0 7150700.0 True False 5282934.948536556 5672610.734510526 5849345.97237795 1.0 1.0737612311660047 1.1072152183131267 22.332908214686434 -13.999999999955698 0.10655435454830695 0.6417090902678977 1.1717456379488465 0.9997605634997028 0.0006930387237521614 12.034189872220463 0.09847448209625653 0.9339151408856434 0.05737746451231301 1.00000000010201e-14 13.999999999955698 0.5300365476809488 NTKEPPLSLTIHLTSPVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTKEPPLSLTIHLTSPVVR 19 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7EQR9;K7EKY0;K7EPG3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 4337400.0 1104100.0 1878600.0 1354700.0 False True 1447485.792119609 1598320.2027254452 1214528.6391999926 1.0 1.1042044152882244 0.8390608362528462 20.465117756751688 -6.800074645744276 1.4554449204479862 1.0574877879537192 0.8353867090814167 0.8324433539743531 0.04464526509902967 0.2206395306631805 0.9227006167118436 0.024130822436476254 0.05612093254067372 1.5846208073160296e-07 6.800074645744276 -0.22210107887230257 NTKEPPLSLTIHLTSPVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NTKEPPLSLTIHLTSPVVR 19 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7EQR9;K7EKY0;K7EPG3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 394358000.0 104091000.0 159641000.0 130626000.0 False True 157913657.0714284 131151816.26917388 104807713.84459026 1.0 0.8305286490189417 0.6637026574413577 27.234560706340098 -6.9713187279673186 0.22446341490068997 1.0727255915928267 0.41677029887325445 0.9999909202262193 0.00041366379120363894 0.07587709529275308 0.007480416355473482 0.004467003806971091 0.01675260655508818 1.0682705895298759e-07 6.9713187279673186 -0.6559552927195722 NTKEPPLSLTIHLTSPVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTKEPPLSLTIHLTSPVVR 19 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7EQR9;K7EKY0;K7EPG3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 11897200.0 1104100.0 6122500.0 4670600.0 False True 1512315.6071805977 5851987.705599971 3567500.4740264365 1.0 3.8695545280457706 2.358965587002907 20.52832781827458 -9.569368072250263 6.570093451339372 1.0000000018906579 3.1142600575360686 0.7231403571397619 0.616695352816554 9.29807756794856e-09 0.0 0.5971127077668207 0.19903756925560684 2.6954540191899233e-10 9.569368072250263 2.1142600556454108 NTKEPPLSLTIHLTSPVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NTKEPPLSLTIHLTSPVVR 19 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7EQR9;K7EKY0;K7EPG3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 338424000.0 104091000.0 99627000.0 134706000.0 False True 134747851.44036224 94082669.8708285 110190890.2002801 1.0 0.6982127645461444 0.8177561944210238 27.005687028432547 -10.062668650821736 5.680813215231253 1.0000011456147482 0.7579844796856576 0.8453160142723085 0.04880340088279545 7.081183169481305e-07 1.1682365721012229e-07 0.0472539132670289 0.015751229904751706 8.656281062370496e-11 10.062668650821736 -0.24201666592909055 NTLDGYGIHPK(ub)SIDLDNYFTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTLDGYGIHPKSIDLDNYFTAR 22 1 J9JIE5;Q14494-2;Q14494;J3QLQ1;J3QQY8 J9JIE5 NFE2L1 Nuclear factor erythroid 2-related factor 1 1 28718900.0 6667800.0 3381700.0 18669400.0 True False 5544571.133624571 3363482.110885105 22573085.22244748 1.0 0.6066261988213225 4.071204909890137 22.402644443178932 -6.878674566762326 1.0872171666830437 0.7602426791978388 4.310530621445793 0.9725981705090809 0.25638838582909945 0.1288081852959806 0.27946499228431826 0.18187583555446846 0.4383602904440706 1.322286101898027e-07 6.878674566762326 3.550287942247954 up NTLEWCLPVIDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTLEWCLPVIDAK 13 0 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 0 9099800.0 1821200.0 3072400.0 4206200.0 False True 2387610.836525888 2614009.896121401 3770982.7727194307 1.0 1.0948224292384836 1.5793959028123816 21.187136276124797 -6.939319887777215 0.6658644273951932 0.9944918448301843 1.7074947483603864 0.9980734109130707 0.011137836497488741 0.08807832911688532 0.056033705889132354 0.010786759726109275 0.04183281054405921 1.149953057348886e-07 6.939319887777215 0.7130029035302021 NTLEWCLPVIDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTLEWCLPVIDAK 13 0 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 0 8541100.0 1821200.0 2944200.0 3775700.0 False True 2494546.856079437 2814115.508832575 2883957.4229824054 1.0 1.1281068952360307 1.156104731387963 21.250346337647688 -13.999999999999927 0.21370992687570575 0.24758039164928014 1.172014324285208 0.9994924100528171 0.001531054087885127 12.836254076959014 0.1465003867835717 4.062813488036066 0.016164000224311883 1.0000000000001677e-14 13.999999999999927 0.9244339326359278 NTLEWCLPVIDAKNK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTLEWCLPVIDAKNK 15 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 36073000.0 11182000.0 12325000.0 12566000.0 True False 14659710.286642047 10486158.042473722 11265790.86158345 1.0 0.7153045890701352 0.7684865963448717 23.805353256622222 -10.609769532936891 6.489257836827241 1.000757686071819 0.7418955927075048 0.9691406541728814 0.02171146355334792 0.00023866715577720247 1.4352214347987302e-05 0.02108104422470432 0.00700734473032548 2.4560119018213488e-11 10.609769532936891 -0.2588620933643142 NTLEWCLPVIDAKNK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTLEWCLPVIDAKNK 15 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 30592000.0 15693000.0 9120700.0 5778300.0 True False 15194834.304913916 12762643.07382217 4264789.884715739 1.0 0.8399330205065026 0.28067366837534596 23.857077607003145 -6.9479841432749065 0.580553831488272 1.0066712787497418 0.08624725624967224 0.9990334388888401 0.009587055902939486 0.0843054653345608 0.03939141691466147 0.010038720278620395 0.046725209498390374 1.127238612550353e-07 6.9479841432749065 -0.9204240225000696 down NTLEWCLPVIDAKNK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTLEWCLPVIDAKNK 15 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 40301000.0 11182000.0 16464000.0 12655000.0 True False 15316287.582187718 15736566.04083266 9666149.637906168 1.0 1.027439969143287 0.631102647168074 23.868563318145114 -6.890304289435959 1.02060224617548 1.0211406477608507 0.5968127584949462 0.981091574650767 0.024849753183406226 0.1188957519834051 0.22041884810924744 0.018544896776688448 0.046282723795614406 1.287347252792859e-07 6.890304289435959 -0.4243278892659045 NTLEWCLPVIDAKNK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTLEWCLPVIDAKNK 15 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 35389600.0 15693000.0 6502600.0 13194000.0 True False 13049424.817776537 6467569.203134965 15952804.397836672 1.0 0.49562101728227437 1.2224910002243943 23.63748288243742 -6.720091158548197 1.759223549549483 0.6931689716455287 1.2213458248922602 0.5128574292612232 0.21224192586008706 0.35513212161286656 2.148074684908665 0.0957971984274057 0.2404395632753318 1.9050608031324874e-07 6.720091158548197 0.5281768532467315 NTLEWCLPVIDAKNK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NTLEWCLPVIDAKNK 15 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 71165000.0 22709000.0 30195000.0 18261000.0 True False 29397248.161312614 28514621.70646176 14937685.373682795 1.0 0.9699758817557486 0.5081320976614776 24.809177776761675 -6.920120906785084 0.8238312667315931 1.0101460093881243 0.43344855343867056 0.994214375121146 0.01712381915714592 0.0981007995526559 0.10524670249482052 0.014763348064718858 0.044274370955989004 1.2019297729965592e-07 6.920120906785084 -0.5766974559494538 NTLFNLSNFLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTLFNLSNFLDK 12 0 Q13492-3;Q13492-2;Q13492-4;Q13492;Q13492-5;E9PLJ8;E9PKP6;E9PI56;E5RFU0;E5RFC6;E5RK51;E5RIJ5;E5RGY9;E5RHK9;E9PDG8;O60641-4;O60641-3;O60641 Q13492-3 PICALM;SNAP91 Phosphatidylinositol-binding clathrin assembly protein;Clathrin coat assembly protein AP180 0 4670000.0 1028200.0 2091600.0 1550200.0 False True 1347980.1571029634 1779541.432992942 1389800.1745684133 1.0 1.3201540272057688 1.031024208513075 20.362367828855923 -10.346453091284603 3.8651433950361667 0.9994790914849856 1.175589117878128 0.32964831779096293 0.11803675427044673 84168684.15830688 308.26196404208696 391716.65742433985 0.040407120570580796 4.5034662118918213e-11 10.346453091284603 0.17611002639314233 NTLFNLSNFLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTLFNLSNFLDK 12 0 Q13492-3;Q13492-2;Q13492-4;Q13492;Q13492-5;E9PLJ8;E9PKP6;E9PI56;E5RFU0;E5RFC6;E5RK51;E5RIJ5;E5RGY9;E5RHK9;E9PDG8;O60641-4;O60641-3;O60641 Q13492-3 PICALM;SNAP91 Phosphatidylinositol-binding clathrin assembly protein;Clathrin coat assembly protein AP180 0 7201900.0 3097700.0 1441700.0 2662500.0 False True 2999365.2090952555 2017378.32836618 1965111.3767121222 1.0 0.6726017632826756 0.6551757587749338 21.516225767846922 -13.999999999999998 0.4180650004620347 7.202003324010399 0.6545684513492913 0.9998617517178267 0.0018648413785241449 29.631067055856835 0.21538898223732775 167.77571941468605 0.004249392484686638 1.0000000000000041e-14 13.999999999999998 -6.547434872661108 NTLFNLSNFLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTLFNLSNFLDK 12 0 Q13492-3;Q13492-2;Q13492-4;Q13492;Q13492-5;E9PLJ8;E9PKP6;E9PI56;E5RFU0;E5RFC6;E5RK51;E5RIJ5;E5RGY9;E5RHK9;E9PDG8;O60641-4;O60641-3;O60641 Q13492-3 PICALM;SNAP91 Phosphatidylinositol-binding clathrin assembly protein;Clathrin coat assembly protein AP180 0 7843900.0 1028200.0 2675300.0 4140400.0 False True 1408353.3260602213 2557096.39996596 3162522.7942146766 1.0 1.8156639762546478 2.245546437598605 20.425577890378815 -9.518324361388691 0.17071728774659653 1.6203198477673543e-18 2.795943960831908 0.9996694553526797 0.009391486796917845 0.9660253847679457 0.06855350247406984 0.7811362258816675 0.3038251453900576 3.031626108764118e-10 9.518324361388691 2.795943960831908 NTLFNLSNFLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTLFNLSNFLDK 12 0 Q13492-3;Q13492-2;Q13492-4;Q13492;Q13492-5;E9PLJ8;E9PKP6;E9PI56;E5RFU0;E5RFC6;E5RK51;E5RIJ5;E5RGY9;E5RHK9;E9PDG8;O60641-4;O60641-3;O60641 Q13492-3 PICALM;SNAP91 Phosphatidylinositol-binding clathrin assembly protein;Clathrin coat assembly protein AP180 0 4204400.0 3097700.0 1106700.0 0.0 False True 2575874.8013780913 1100737.987437249 0.0 1.0 0.4273258882179968 0.0 21.2966310432812 -8.175295867805536 0.5513018323613414 1.0249190816241849 7.292437719961235e-16 0.991016134012828 0.038831109716651005 0.12473076216247815 0.17206349018844058 0.05254777008495751 0.07346913361564475 6.6788875611707395e-09 8.175295867805536 -1.0249190816241842 NTLIMGLGTQGAEK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTLIMGLGTQGAEKK 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 93383500.0 25948500.0 40801000.0 26634000.0 True False 34018734.785631455 34713649.84105232 23878169.171368264 1.0 1.0204274221190137 0.7019123233664093 25.019826149938346 -6.891599379807395 1.012890205951486 1.01646380722054 0.6736447264330186 0.9819018114476035 0.019583962115986175 0.11785440898297976 0.21435256493563198 0.014700507877587376 0.03686545082174359 1.283514029755583e-07 6.891599379807395 -0.34281908078752144 NTLIMGLGTQGAEK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 2 NTLIMGLGTQGAEKK 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 146182300.0 27702200.0 81791100.0 36689000.0 True False 26822808.824417647 114450712.7649517 27079050.253592823 1.0 4.266917514647594 1.0095531169331495 24.676956985155563 -6.645479664969036 2.024568381848912 3.127396510031824 1.0231615950036697 0.17601884104532073 1.3959070584845128 0.5196594796007681 4.077357027522861 0.5601732550492069 1.5460127968644606 2.2621444579946523e-07 6.645479664969036 -2.1042349150281545 NTLIMGLGTQGAEK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 NTLIMGLGTQGAEKK 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 39978600.0 12259600.0 16087000.0 11632000.0 True False 18598709.496814188 13216149.161695326 9332930.101513285 1.0 0.7105949562768937 0.5018052517628678 24.148699185161128 -7.6399992052733 0.13695411996029475 1.3464690615978618 1.013292937974055e-14 0.9999846197754767 0.0008010887295894918 0.1362089830540219 0.015065341065172396 0.05517751102635439 0.08252883489427973 2.2908718448895503e-08 7.6399992052733 -1.3464690615978516 NTLIMGLGTQGAEK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTLIMGLGTQGAEKK 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 77876500.0 25948500.0 51928000.0 0.0 True False 35542361.68184563 49633649.25706742 0.0 1.0 1.3964645822176571 0.0 25.083036211461238 -6.858576989435833 1.3867322733626883 1.2095689889252093 1.4841667519650562e-22 0.9066605172600483 0.17951587381651804 0.16671976067081434 0.6445104374067201 0.10433853310461354 0.21809660051973304 1.3849146537942442e-07 6.858576989435833 -1.2095689889252093 down NTLIMGLGTQGAEK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTLIMGLGTQGAEKK 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 26352700.0 6925200.0 11636000.0 7791500.0 True False 5758610.638377996 11573314.558434842 9420666.62617434 1.0 2.009740766514933 1.6359270000633035 22.45728934854328 -10.412522085207245 5.114891796311203 0.9991863714111112 1.8228338832891624 0.8659570801616813 0.1526088311058893 0.0014172057005214878 0.00016277486241910808 0.14789522242814787 0.049254288446418736 3.8679238455310274e-11 10.412522085207245 0.8236475118780512 NTLIMGLGTQGAEK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NTLIMGLGTQGAEKK 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 43280300.0 12259600.0 23861100.0 7159600.0 True False 15870293.872844594 22533208.809407383 5856626.263699654 1.0 1.4198356369420226 0.36903073822223503 23.919825507253577 -6.798295688118245 1.4629400167065627 1.2321518368452353 0.35514493249480916 0.8270844595766217 0.1795833825022243 0.22321696565208735 0.9433317818898393 0.0965799987492015 0.2248388241444578 1.5911250453838026e-07 6.798295688118245 -0.8770069043504262 down NTLLIAGLQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTLLIAGLQAR 11 0 A0A0C4DGS1;P39656;P39656-3;P39656-2 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 0 27648500.0 8916700.0 8367800.0 10364000.0 False True 11689880.049445633 7119356.857428928 9291632.698507953 1.0 0.6090188117684362 0.7948441437556572 23.478756790577446 -10.080256444544544 4.860788889628366 1.0000100840910835 0.7019314777593196 0.7742933313470509 0.07586287411807228 105407777.42994995 9.07215598461335 11896.893012921557 0.025969879643354152 8.312727717299349e-11 10.080256444544544 -0.29807860633176386 NTLLIAGLQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTLLIAGLQAR 11 0 A0A0C4DGS1;P39656;P39656-3;P39656-2 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 0 12876000.0 5231900.0 2871400.0 4772700.0 False True 5065816.198297263 4017964.9941531816 3522586.692069088 1.0 0.7931525418359457 0.6953640941913981 22.27236330239205 -13.9999999999999 0.09967339646573409 2.0225104252228694 0.4860265335081313 0.9997953510267578 0.0018167370857399318 12.082843003363056 0.09395420450923332 2.5434350908762746 0.18673537364829218 1.0000000000002291e-14 13.9999999999999 -1.536483891714738 NTLLIAGLQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NTLLIAGLQAR 11 0 A0A0C4DGS1;P39656;P39656-3;P39656-2 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 0 17087000.0 2935000.0 7260100.0 6891900.0 False True 4452609.577241475 5964478.431579789 5529712.944172926 1.0 1.3395466923634842 1.2419038427345677 22.086219685333297 -10.114121148489586 4.393791099059132 0.9999663558399794 1.290725267431551 0.9219978593891992 0.03986252655236431 21004663.907161932 0.3634949198254084 7915.573366381331 0.014588190944940143 7.689159176530816e-11 10.114121148489586 0.29075891159157163 NTLLIAGLQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTLLIAGLQAR 11 0 A0A0C4DGS1;P39656;P39656-3;P39656-2 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 0 23649500.0 8916700.0 6257000.0 8475800.0 False True 12213444.954757035 5980545.050867953 6473990.604580414 1.0 0.4896689732521848 0.5300708054576239 23.541966852100337 -9.961119130494662 6.070920240414486 1.0000002417399763 0.5098698893548346 0.9949297068626819 0.01649397892972691 5.3944530179583565e-08 9.251008715281215e-09 0.015970234279759698 0.005323408808924252 1.0936563263321168e-10 9.961119130494662 -0.4901303523851417 NTLLIAGLQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NTLLIAGLQAR 11 0 A0A0C4DGS1;P39656;P39656-3;P39656-2 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 0 12725900.0 2935000.0 6559800.0 3231100.0 False True 3799415.3574993345 6194741.363472366 2643072.953885688 1.0 1.6304459451228743 0.6956525426125777 21.857346007425747 -6.725040380664588 1.7413720520880722 1.3814799941148435 0.696698145823295 0.5361131160639174 0.2651432293213389 0.34560935824080535 2.0507670323665854 0.12077976465318466 0.30139765394027695 1.8834739560971445e-07 6.725040380664588 -0.6847818482915484 NTLQLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTLQLHR 7 0 P61313;E7ERA2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 28837200.0 3488200.0 15302000.0 10047000.0 False True 4573063.979776851 13019001.246728832 9007432.817629244 1.0 2.846888061112172 1.9696712876666935 22.12472967273782 -10.114437313762409 5.757224742896603 0.9999887721915058 2.4082796743895414 0.7745916070430823 0.35812224812572824 5.1612226251923e-05 7.938320373557989e-06 0.34675313221953413 0.11558345857471924 7.683563525359846e-11 10.114437313762409 1.4082909021980354 NTLQLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTLQLHR 7 0 P61313;E7ERA2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 14877700.0 4617600.0 2438000.0 7822100.0 False True 4471016.815546446 3411506.11400204 5773257.352030004 1.0 0.7630269029943444 1.2912627239413323 22.092171541207826 -6.784737346240339 1.5171383514461823 0.8666410992841083 1.296105338080055 0.7838479422491472 0.10043732239685182 0.24330144181705618 1.1063013806769737 0.052123741733707 0.12252658683492758 1.6415822734931912e-07 6.784737346240339 0.42946423879594664 NTLQLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTLQLHR 7 0 P61313;E7ERA2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 20973900.0 3488200.0 8971600.0 8514100.0 False True 4777881.805060557 8575205.046886187 6503244.933393672 1.0 1.7947712808223184 1.3611146526282156 22.187939734260713 -10.179129457466978 4.471121536671632 0.9999064418502517 1.577942966518994 0.7031047191972812 0.17703957799492 0.00021798727390302878 4.0021320436706075e-05 0.17145417702230226 0.05713927796643543 6.620191350989419e-11 10.179129457466978 0.5780365246687422 NTLQLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTLQLHR 7 0 P61313;E7ERA2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 7286800.0 4617600.0 1552200.0 1117000.0 False True 3839738.9943646737 1543837.990512423 1350559.5355755305 1.0 0.4020684720441181 0.35173211969815027 21.872576816642102 -13.999999999999998 0.3505543100278928 8.378402619019626 0.3448286775120403 0.9997557639288525 0.004601676526813171 20.715199228022872 0.190634680679723 113.846778790488 0.014990219588075619 1.0000000000000041e-14 13.999999999999998 -8.033573941507585 NTLQLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NTLQLHR 7 0 P61313;E7ERA2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 3285410.0 341810.0 1320800.0 1622800.0 False True 442479.7830824018 1247296.3189234873 1327467.0513341252 1.0 2.8188775320638926 3.00006260644662 18.755252014348677 -10.374379671580442 0.4792169709067442 5.651887295639093e-15 2.997660732529376 0.9994701446651176 0.02078962466507804 1.7461131703923218 0.22524166498539525 2.2705322696514125 0.03826341562460511 4.22299267792024e-11 10.374379671580442 2.9976607325293703 NTMTTK(ub)ECLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTMTTKECLHR 11 1 Q06587;Q06587-2;X6RFN3;Q99496-2;Q99496 Q06587;Q99496-2 RING1;RNF2 E3 ubiquitin-protein ligase RING1;E3 ubiquitin-protein ligase RING2 1 1760310.0 477660.0 708940.0 573710.0 True False 626216.8856660196 603168.9154264763 514347.9926149168 1.0 0.9631949077594252 0.8213575909373261 19.256302885082327 -6.945731226115067 0.6038963121490307 1.001584897787276 0.7756581796872344 0.9988222492232263 0.0026431162759224776 0.0852465551058195 0.0434154385883507 0.0027024247183083743 0.011935013508923807 1.1331013941196508e-07 6.945731226115067 -0.22592671810004172 NTMTTK(ub)ECLHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NTMTTKECLHR 11 1 Q06587;Q06587-2;X6RFN3;Q99496-2;Q99496 Q06587;Q99496-2 RING1;RNF2 E3 ubiquitin-protein ligase RING1;E3 ubiquitin-protein ligase RING2 1 7465150.0 989650.0 2027200.0 4448300.0 True False 1501371.403106311 1665430.3214141056 3569091.5552408486 1.0 1.109272707584785 2.377220951362508 20.517849478421034 -6.923881957867348 0.7953848039158796 0.9757420363730158 2.601148801700462 0.9951935901297964 0.04333476809098016 0.09594075631289166 0.09416364380905165 0.038126959816945666 0.1188189058286176 1.1915658340594441e-07 6.923881957867348 1.625406765327446 up NTMTTK(ub)ECLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NTMTTKECLHR 11 1 Q06587;Q06587-2;X6RFN3;Q99496-2;Q99496 Q06587;Q99496-2 RING1;RNF2 E3 ubiquitin-protein ligase RING1;E3 ubiquitin-protein ligase RING2 1 10632500.0 1651770.0 1983730.0 6997000.0 True False 2138248.8262544046 1873333.681661185 5723617.795282765 1.0 0.8761064936220382 2.6767781770790884 21.027998317385073 -6.890409512905383 1.019923808046424 0.9041958819037097 2.8329203131848706 0.9811602747823528 0.11271643162927586 0.1188128293351512 0.2198956937754619 0.08415849977273844 0.2101268972184618 1.2870353843687032e-07 6.890409512905383 1.928724431281161 up NTSGILGFSVTVGTQATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NTSGILGFSVTVGTQATK 18 0 O43847-2;G3V1R5;O43847 O43847-2 NRD1 Nardilysin 0 19624800.0 6069400.0 9969700.0 3585700.0 False True 7856957.9457603 9414877.43092936 2933139.392388942 1.0 1.1982853282305947 0.37331743565863124 22.905539407752748 -6.843242226335697 1.2672403055999222 1.1054798428040071 0.34439220562902184 0.929889600231304 0.09309865850525514 0.16504425528743397 0.5134417754851386 0.05757345937663288 0.13277720452572628 1.4346890170235182e-07 6.843242226335697 -0.7610876371749853 down NTSSHVQELVAQK(ub)AR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTSSHVQELVAQKAR 15 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 25329400.0 7664400.0 10605600.0 7059400.0 True False 10048102.622155188 9023285.820305018 6328961.006546423 1.0 0.8980089236359372 0.6298662786934139 23.260419768000204 -6.954374037948232 0.5085637796660424 1.0049938140072134 0.5111463477613527 0.9995013328204223 0.0034858161029269756 0.08177546798025552 0.029050689551097488 0.004025003107023269 0.022128407353750854 1.1107746558580115e-07 6.954374037948232 -0.49384746624586073 NTSSHVQELVAQK(ub)AR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTSSHVQELVAQKAR 15 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 43259600.0 8967900.0 8767700.0 25524000.0 True False 8683218.923280278 12268688.332951467 18838498.696413226 1.0 1.4129193840844334 2.1695293949005454 23.049798527176094 -6.961720286283027 0.41047010404600076 0.9629193662299637 2.6476294804507003 0.9998287756774841 0.006336956626759771 0.07909222382394938 0.018902225349082966 0.009744010630101916 0.06316168050316598 1.0921435209945249e-07 6.961720286283027 1.6847101142207368 up NTSSHVQELVAQK(ub)AR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NTSSHVQELVAQKAR 15 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 105188200.0 18469000.0 17147200.0 69572000.0 True False 28018823.26476074 14087148.188314894 55821063.7055091 1.0 0.5027744404252799 1.9922700956437103 24.73989303091021 -6.816727020645939 1.3862217371922427 0.731084550375897 2.022495077527122 0.8766289961433786 0.21748130828706774 0.19777414058151965 0.7476721218312063 0.12332045082572687 0.2844778856770437 1.5250110107683327e-07 6.816727020645939 1.2914105271512253 NTSSHVQELVAQK(ub)AR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTSSHVQELVAQKAR 15 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 24853700.0 7664400.0 6631100.0 10558200.0 True False 10498135.802622031 6338116.075884676 8064570.612954626 1.0 0.6037372915581505 0.7681907306762412 23.323629829523096 -10.155591196231049 5.280828797581111 1.0000109094057266 0.6859640111170443 0.829408683268306 0.06713783538139391 8.623541986179786e-06 1.3789410881523586e-06 0.06500818642328146 0.021668643194302974 6.98889963488094e-11 10.155591196231049 -0.31404689828868226 NTSSHVQELVAQK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTSSHVQELVAQKAR 15 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 39769000.0 8967900.0 19050800.0 11750300.0 True False 7457206.195331557 18948169.55911226 14207233.402751252 1.0 2.5409206964096556 1.9051683741352656 22.83020380261037 -10.435173274234742 5.6981412627477805 0.9992604291263621 2.2230445352724626 0.8314951674191967 0.2595447987269573 0.002439767309717605 0.00024184037244753023 0.25143123118438443 0.08376772358868748 3.6713579192318936e-11 10.435173274234742 1.2237841061461006 NTSSHVQELVAQK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NTSSHVQELVAQKAR 15 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 78585600.0 18469000.0 17120600.0 42996000.0 True False 23908484.57841744 16167823.559783068 35171169.176215254 1.0 0.6762379065370798 1.4710748002809353 24.51101935300266 -6.79611815537076 1.4716841912889176 0.8204745025338571 1.4810255909825203 0.8205611870888069 0.1382396996981173 0.22635598931315418 0.9682306501048313 0.07391063105732279 0.17231311923722661 1.5991229075788564e-07 6.79611815537076 0.6605510884486632 NTTIK(ub)EESKPEQCLAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTTIKEESKPEQCLAGK 17 2 Q14693;Q14693-2;Q14693-4;Q14693-3;Q14693-5;Q14693-7;A0A0A0MS66;H7C3T1 Q14693 LPIN1 Phosphatidate phosphatase LPIN1 1 5380160.0 1517100.0 2919900.0 943160.0 True False 2078012.8680859392 2790889.163181925 720405.0329899319 1.0 1.3430567279174828 0.3466797747280064 20.98677315747693 -6.813750946837493 1.398712087180501 1.1861528458526882 0.32771342625680244 0.8693905193674885 0.14936295776467878 0.20173295423724222 0.7771151466807943 0.08394924604034548 0.1938827994080491 1.5354972860023175e-07 6.813750946837493 -0.8584394195958858 down NTTIPTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTTIPTK 7 0 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6;P11142-2;P54652;P38646 A8K7Q2;P11142;P38646 HSPA8;HSPA2;HSPA9 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Stress-70 protein, mitochondrial 0 6444300.0 2684700.0 1501600.0 2258000.0 False True 2599475.6680304804 2101196.710740553 1666562.0614520067 1.0 0.8083155909409018 0.6411146993788538 21.309789220494153 -6.972726970606291 0.18159916959215686 1.126547823855644 0.3183538335038308 0.9999965801998039 0.0002710931588560745 0.07542741720598185 0.0057373850160470155 0.0063484882323600255 0.018673283436521217 1.0648122269811715e-07 6.972726970606291 -0.8081939903518132 NTTIPTK(ub)QTQTFTTYSDNQPGVLIQVYEGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 NTTIPTKQTQTFTTYSDNQPGVLIQVYEGER 31 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 8008300.0 3375000.0 3649500.0 983800.0 True False 4424657.683546497 3105008.825639584 882005.8132759669 1.0 0.7017511969764011 0.19933876841044404 22.077134413818516 -7.236377660824434 0.4627099495578227 1.0164314077135665 1.001664023013432e-24 0.999247566490484 0.00906281906133931 0.09271391138789462 0.03577538223627808 0.011171447693836689 0.04960890217801621 5.802596065223836e-08 7.236377660824434 -1.0164314077135665 down NTTIPTK(ub)QTQTFTTYSDNQPGVLIQVYEGER ddPTM_RPMI8226_Bortezomib_2h_R1 1 NTTIPTKQTQTFTTYSDNQPGVLIQVYEGER 31 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 125151000.0 49319000.0 25585000.0 50247000.0 True False 47753395.340855666 35801223.92401242 37085803.322311305 1.0 0.7497105424330425 0.7766108159974617 25.50909997887337 -10.006551897089977 5.750944930871918 1.000000458340753 0.7631606793535646 0.9904173548872619 0.010981990695963567 3760945.098033117 6543984.116111939 15.977760404640401 0.003759427514063727 9.850269275492984e-11 10.006551897089977 -0.23683977898718833 NTTIPTK(ub)QTQTFTTYSDNQPGVLIQVYEGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 NTTIPTKQTQTFTTYSDNQPGVLIQVYEGER 31 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 320967000.0 99717000.0 115260000.0 105990000.0 True False 151277979.28919542 94690952.4695096 85041030.04293266 1.0 0.6259400932933576 0.5621507534838315 27.172626756683986 -13.999999999999998 0.24885702236646262 3.586502069186173 0.5362217540676357 0.9995405535453763 0.004139736006747387 13.952934987369643 0.15785671346355853 18.028408691555008 0.029626585602785513 1.0000000000000041e-14 13.999999999999998 -3.0502803151185374 NTTIPTK(ub)QTQTFTTYSDNQPGVLIQVYEGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NTTIPTKQTQTFTTYSDNQPGVLIQVYEGER 31 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 8131000.0 3375000.0 1525600.0 3230400.0 True False 4622828.705945588 1458193.9475154453 2467446.052176377 1.0 0.3154332639753684 0.5337524293303156 22.140344475341408 -10.222802565483326 5.007485770234567 1.0000738191354976 0.4245928466524863 0.902553259781313 0.08912842603339365 7.346209259974467e-05 1.1401816869159534e-05 0.08630923540614768 0.028766075808168888 5.986837006671177e-11 10.222802565483326 -0.5754809724830113 NTTIPTK(ub)QTQTFTTYSDNQPGVLIQVYEGER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTTIPTKQTQTFTTYSDNQPGVLIQVYEGER 31 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 116654000.0 49319000.0 35215000.0 32120000.0 True False 41010933.70215508 35025289.80536982 38836143.49389975 1.0 0.8540476073952267 0.9469704780669002 25.289505254307645 -10.368966624523413 5.124698622507679 1.0000580665112002 0.9005090427335187 0.6045059961509334 0.03793560309673475 2.5182460352885898e-05 3.1008553987762075e-06 0.036752410420013114 0.012243663251828126 4.2759574556848704e-11 10.368966624523413 -0.09954902377768149 NTTIPTK(ub)QTQTFTTYSDNQPGVLIQVYEGER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NTTIPTKQTQTFTTYSDNQPGVLIQVYEGER 31 1 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 308319000.0 99717000.0 132980000.0 75622000.0 True False 129085622.21593235 125579546.1011851 61859571.947245106 1.0 0.9728391430853365 0.4792134932251975 26.943753078776435 -6.918252131146227 0.837587798699588 1.0115928177394933 0.4027264666055786 0.9936814324246482 0.01902628537611388 0.09921130492743041 0.11102395965049194 0.016243119920023873 0.04787180256662737 1.207112838158333e-07 6.918252131146227 -0.6088663511339147 down NTVLATWQPYTTSK(ub)DGTAGIPNLQLYDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NTVLATWQPYTTSKDGTAGIPNLQLYDVK 29 1 Q9BY44;Q9BY44-3;F8WAE5;C9IZE1;H7C5Q3 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 1 14309800.0 5163100.0 4330900.0 4815800.0 True False 4293346.414112146 4307568.582083653 5822761.514256623 1.0 1.003312606670815 1.356229139842366 22.033671152489333 -6.908956970669986 0.9028269641100296 0.9887083150673823 1.400831526873299 0.990520968119442 0.01627404018686394 0.10511292507375675 0.1425477434204146 0.013255260616060513 0.03633056269762611 1.2332270136978084e-07 6.908956970669986 0.4121232118059166 NVADYYPEYK(ub)LLFEGAGSNPGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVADYYPEYKLLFEGAGSNPGDK 23 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 10422700.0 2518300.0 3073400.0 4831000.0 True False 2438357.944947726 4300624.647569265 3565616.1731065772 1.0 1.7637380338190924 1.462302194185447 21.217478494911347 -10.134376273013565 4.879560050123497 0.9999645483547912 1.6130201139219438 0.8464939645254891 0.12306066622642468 4.901595449926992e-05 8.695308727220838e-06 0.1191600736387874 0.03971765923736453 7.338777604794197e-11 10.134376273013565 0.6130555655671526 NVADYYPEYK(ub)LLFEGAGSNPGDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVADYYPEYKLLFEGAGSNPGDK 23 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 46441600.0 6538600.0 11595000.0 28308000.0 True False 9919534.235690344 9525781.657851517 22712911.392162833 1.0 0.9603053360688941 2.2897155100732554 23.241840950860205 -6.900015947310242 0.9611499218576458 0.9447521690199762 2.429313113662555 0.9865747362097841 0.0715535327687931 0.1113941273759998 0.17734625866803666 0.0558322013447476 0.14528022235920957 1.2588791848528878e-07 6.900015947310242 1.484560944642579 up NVADYYPEYK(ub)LLFEGAGSNPGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVADYYPEYKLLFEGAGSNPGDK 23 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 12191100.0 2518300.0 4074800.0 5598000.0 True False 2094078.029605978 4052848.243615524 6768515.917772448 1.0 1.9353854948653029 3.232217626124473 20.997883770345624 -6.966532778008589 0.33069153707934495 0.8432730996444066 4.3668275019637255 0.9999413434694845 0.007009846244744927 0.07744460920457966 0.013046467180585506 0.01887649315348875 0.113049755745835 1.0801080975606339e-07 6.966532778008589 3.523554402319319 NVADYYPEYK(ub)LLFEGAGSNPGDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVADYYPEYKLLFEGAGSNPGDK 23 1 F5GYQ1;P61421;J3QL14;R4GN72 F5GYQ1 ATP6V0D1 V-type proton ATPase subunit d 1 1 58710600.0 6538600.0 10918000.0 41254000.0 True False 8464346.595075022 10310403.702306677 33746195.30178582 1.0 1.218098005143809 3.9868635957583582 23.012967272952654 -6.922598144243244 0.8052279228367712 0.9444384024649082 4.461162792167372 0.9948725908433738 0.09735066502727015 0.09666718778944036 0.09787057934216419 0.08505273290701112 0.26145861460198105 1.1950934214047773e-07 6.922598144243244 3.516724389702464 up NVAELPTK(ub)VEEIPHPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVAELPTKVEEIPHPK 16 1 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 16551900.0 2835900.0 0.0 13716000.0 True False 3671128.453946293 0.0 11219828.738044664 1.0 0.0 3.0562343101843434 21.807792165000823 -6.818581728493312 1.3781173768488215 0.46023469929998345 3.120882103444342 0.8810661245216788 0.4387745700003406 0.19533085754937032 0.729343161484765 0.2502285123138778 0.5769329467917881 1.5185121511833782e-07 6.818581728493312 2.6606474041443584 NVAIFTAGQESPIILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVAIFTAGQESPIILR 16 0 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 0 2166640.0 0.0 897440.0 1269200.0 False True 0.0 763545.450193721 1137875.3590260805 0.0 NVALLSQLYHSPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVALLSQLYHSPAR 14 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 0 129177500.0 35780500.0 36307000.0 57090000.0 False True 46908581.99885492 30890137.123577524 51182874.445949346 1.0 0.6585178192837204 1.0911196259822726 25.48334855442637 -6.696290806792537 1.8442016743115601 0.7871837082396388 1.0897418659403117 0.39992296562261653 0.144244527143684 0.40330211030252355 2.664057055141359 0.06246233786548818 0.16136998677523098 2.0123762965825476e-07 6.696290806792537 0.30255815770067296 NVALLSQLYHSPAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVALLSQLYHSPAR 14 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 0 118049500.0 44191000.0 18130500.0 55728000.0 False True 42788180.89393044 25370103.199308474 41131164.99583587 1.0 0.592923154695442 0.9612739811911559 25.350709009424584 -10.35413059847263 8.348771552280143 1.0000009034347108 0.777098567943299 0.3280693244425785 0.15037859520782623 2.5287095930467253e-06 1.955596331792552e-07 0.14560403773711053 0.04853448290549814 4.424552998096225e-11 10.35413059847263 -0.2229023354914118 NVALLSQLYHSPAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVALLSQLYHSPAR 14 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 0 136067100.0 25929000.0 75024000.0 35114100.0 False True 39336188.66381409 61635381.03481257 28173782.74394322 1.0 1.5668874674559363 0.7162306186989762 25.229353843938068 -6.727095293287891 1.7340736955222138 1.3422514904151521 0.7170217977067184 0.5456614492830989 0.2383647171877305 0.34169784705108575 2.0116218243247075 0.1089981770302416 0.2713395207074178 1.8745831402101665e-07 6.727095293287891 -0.6252296927084338 NVALLSQLYHSPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVALLSQLYHSPAR 14 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 0 147949500.0 35780500.0 42949000.0 69220000.0 False True 49009517.781655125 41051371.166649714 52871661.63064913 1.0 0.8376203852798518 1.0788039553092614 25.546558615949262 -6.725315607800788 1.740088007430308 0.901774856521026 1.0785476622438426 0.5374927331338397 0.06828942975168681 0.3451037261717393 2.044827093535269 0.031126891528528437 0.07765882273874342 1.8822807129387692e-07 6.725315607800788 0.17677280572281662 NVALLSQLYHSPAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVALLSQLYHSPAR 14 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 0 85016700.0 44191000.0 18649700.0 22176000.0 False True 36746774.49323664 18549230.36442439 26812899.069760915 1.0 0.5047852667405798 0.7296667378165644 25.13111428485886 -10.340127794293942 5.842337379573142 1.0000534252268423 0.6172260022785717 0.7943624342300271 0.0918074761237727 6.3895961236069e-05 7.216816088185132e-06 0.08890456735455732 0.02963073550705842 4.569537078945795e-11 10.340127794293942 -0.38282742294827055 NVALLSQLYHSPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVALLSQLYHSPAR 14 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 0 83019000.0 25929000.0 33209000.0 23881000.0 False True 33565601.63700183 31360889.95694287 19534903.03975245 1.0 0.9343163365905963 0.581991744137775 25.000480166030517 -6.938251267423061 0.6756415092388093 1.0040999632710463 0.49167884965870384 0.9979256800785444 0.008359210381208609 0.08857374527730755 0.058312263641679594 0.008033001176003186 0.03056493116959081 1.152786103586714e-07 6.938251267423061 -0.5124211136123424 NVASK(ub)NIEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVASKNIEIK 10 1 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 1 1135830.0 417570.0 718260.0 0.0 True False 547438.3137536322 611098.407755551 0.0 1.0 1.1162872462568783 0.0 19.062336883067413 -6.951922750310953 1.2005387176165028 1.0660092177761111 2.7865196080225374e-19 0.9724932208246341 0.08310292574908602 0.1068605913409296 0.305967696881943 0.057586156164536904 0.10926602580232822 1.1170619263636351e-07 6.951922750310953 -1.0660092177761111 down NVASK(ub)NIEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVASKNIEIK 10 1 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 1 3226950.0 1184600.0 633350.0 1409000.0 True False 1146995.521417258 886249.9578766173 1039940.630906058 1.0 0.7726708093694589 0.9066649446207774 20.12942832751163 -10.22855734502517 5.104453256386692 1.000018502352902 0.8396678770611953 0.6562404570008046 0.05470287664881014 1.1519652096654484e-05 1.7409630904057174e-06 0.0529719426022043 0.017655277520833793 5.908029497392236e-11 10.22855734502517 -0.16035062529170674 NVASK(ub)NIEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVASKNIEIK 10 1 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 1 1059980.0 417570.0 642410.0 0.0 True False 571956.9134049474 614026.2020342145 0.0 1.0 1.0735532478815968 0.0 19.125546944590305 -6.974725725854306 1.1618334630770863 1.0481750535119576 1.4915577059069364e-21 0.9786191875880358 0.07159936742720108 0.0986492154180029 0.2627785974580847 0.05162858057381033 0.09626253156832991 1.0599228970900677e-07 6.974725725854306 -1.0481750535119576 down NVASK(ub)NIEIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVASKNIEIK 10 1 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 1 3303160.0 1184600.0 1437100.0 681460.0 True False 985047.3866780151 1429358.0570579849 823950.1352849605 1.0 1.451055123224445 0.8364573587303847 19.909833602945906 -6.710012279035724 1.7952139344189126 1.277293850492767 0.8379029839704757 0.46515957753589376 0.19007136403623978 0.3750386440075252 2.3561208067626924 0.08425670722578518 0.21404421659319903 1.9497894715580968e-07 6.710012279035724 -0.4393908665222912 NVASK(ub)NIEIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVASKNIEIK 10 1 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 1 7909300.0 1144300.0 3310300.0 3454700.0 True False 1481318.9075252095 3126078.895012434 2825980.048215432 1.0 2.110334836834744 1.9077458836576275 20.498450835728416 -10.201060810132285 4.622585594106521 0.999795476249503 2.009040360254251 0.9706545741365706 0.08270659382898463 0.00017436393556387428 3.013584511458502e-05 0.08009615641355791 0.026693438372875744 6.294180452548182e-11 10.201060810132285 1.0092448840047479 NVASVCLQIGYPTVASVPHSIINGYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVASVCLQIGYPTVASVPHSIINGYK 26 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;F8VZS0;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 0 79385900.0 48625000.0 9686900.0 21074000.0 False True 47081425.99097934 13554929.686516168 15554087.193551641 1.0 0.28790397489475467 0.33036567746549894 25.48865468125227 -10.324463741843187 5.8922615002405445 1.0000722698269342 0.3091348261801254 0.9971748543903923 0.017334917484697034 1.6459157512105924e-05 1.8870282630149942e-06 0.016786201155831237 0.005594820560508453 4.7373585754199206e-11 10.324463741843187 -0.6909374436468088 NVASVCLQIGYPTVASVPHSIINGYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVASVCLQIGYPTVASVPHSIINGYK 26 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;F8VZS0;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 0 5073896600.0 1825570000.0 1474771000.0 1773555600.0 False True 2769523157.0442023 1211586592.6115851 1423011558.282966 1.0 0.43747119049355104 0.5138110344604185 31.366990455463903 -10.620263696198583 6.544119924322399 1.0017162822922399 0.47564111247725416 0.9843520660401482 0.0311656107937517 0.0007824300677689879 4.540210610528953e-05 0.030254457081046744 0.01005865763154854 2.3973768307056238e-11 10.620263696198583 -0.5260751698149857 NVASVCLQIGYPTVASVPHSIINGYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVASVCLQIGYPTVASVPHSIINGYK 26 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;F8VZS0;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 0 121841000.0 48625000.0 13217000.0 59999000.0 False True 40433841.952742234 13145797.397630906 72544513.49596798 1.0 0.3251186818456502 1.7941533624421757 25.269059956686547 -6.7817637187054975 1.5287618008489823 0.6187484185167141 1.8064946488390652 0.7736785423624366 0.2856247953260996 0.247831571598138 1.144116326928147 0.14713113063009742 0.34669391679661604 1.652860805442062e-07 6.7817637187054975 1.1877462303223512 NVASVCLQIGYPTVASVPHSIINGYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVASVCLQIGYPTVASVPHSIINGYK 26 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;F8VZS0;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 0 3854161900.0 1825570000.0 926238000.0 1102353900.0 False True 2363236352.36459 874692041.0713606 901736801.3061831 1.0 0.37012465562158753 0.38156860629023825 31.138116777556352 -10.010709611773791 5.151098428381802 1.0000048921676647 0.3758466309526754 0.9997479296536512 0.004671973308270102 12893386.319918545 0.008725041326241271 765.3098660772692 0.0015993407288481315 9.756417762993897e-11 10.010709611773791 -0.6241582612149894 NVASVCLQIGYPTVASVPHSIINGYK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVASVCLQIGYPTVASVPHSIINGYKR 27 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;F8VZS0;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 1 206766000.0 49759000.0 94663000.0 62344000.0 True False 75488040.87017334 77769648.04460512 50021681.07365413 1.0 1.0302247501475865 0.6626437843271488 26.169744768994974 -6.886956707011324 1.0401929938949759 1.02121534179936 0.6328482337681033 0.9788787671198773 0.02421408504668749 0.1216481126655828 0.23653708849201902 0.017803612591654406 0.04392621348466948 1.2973085877702348e-07 6.886956707011324 -0.3883671080312566 NVASVCLQIGYPTVASVPHSIINGYK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVASVCLQIGYPTVASVPHSIINGYKR 27 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;F8VZS0;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 1 130159000.0 49759000.0 31072000.0 49328000.0 True False 64414006.396527946 29342815.88551681 40350810.148021765 1.0 0.4555347125108873 0.6264291325030321 25.940871091087423 -10.405329479734615 5.138789489276422 1.0004035925775547 0.5409819225069372 0.9058316535254395 0.0697673548116883 0.00032287144229639923 3.736326820716736e-05 0.06760978682745923 0.022517316941205977 3.932516199006773e-11 10.405329479734615 -0.4594216700706175 NVASVCLQIGYPTVASVPHSIINGYKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVASVCLQIGYPTVASVPHSIINGYKR 27 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;F8VZS0;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 0 1247832000.0 194980000.0 312662000.0 740190000.0 False True 295798914.9473744 256865023.260644 593891122.0631979 1.0 0.8683771652994159 2.00775287552646 28.14004151943678 -6.878133921743526 1.0901096678359614 0.9202637521540151 2.085678850257317 0.9721507445114133 0.08493035862453147 0.12929799730253122 0.28235931940652903 0.06011124052725796 0.14470497025026294 1.3239332159735136e-07 6.878133921743526 1.165415098103302 up NVASVCLQIGYPTVASVPHSIINGYKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVASVCLQIGYPTVASVPHSIINGYKR 27 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;F8VZS0;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 0 1002162000.0 194980000.0 281154000.0 526028000.0 False True 252405453.63039905 265507532.74577105 430296301.50307304 1.0 1.0519088590477033 1.704782108762048 27.91116784152923 -6.922726685453139 0.8042417462906503 0.986961085001929 1.8169639783205624 0.9949055281261732 0.02289038443375793 0.09659377534092038 0.0974934961620093 0.020012758066251395 0.06160406901004209 1.1947397534924435e-07 6.922726685453139 0.8300028933186334 NVCTEAGMFAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVCTEAGMFAIR 12 0 A0A087X2I1;P62333 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 0 6303400.0 1569500.0 1981300.0 2752600.0 False True 2149786.564142692 1893759.6147170658 2102492.571576493 1.0 0.8809058751710421 0.9780006102210155 21.035762002097965 -10.03776232291823 4.4783094318801195 1.0000032912333026 0.9294532426898235 0.4131058008983497 0.03963875961887751 54843952.33472993 4.418271950804658 1957.6722688966636 0.013569401743511497 9.167220489041258e-11 10.03776232291823 -0.07055004854347902 NVDFNYATKDK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVDFNYATKDK 11 1 Q8WWM7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7-3;H3BUF6;Q8WWM7-7;H3BSK9;H3BSQ5;H3BUE3 Q8WWM7 ATXN2L Ataxin-2-like protein 1 7340500.0 1074800.0 1388800.0 4876900.0 True False 1040681.0623157754 1943355.082496326 3599493.5861360896 1.0 1.8673877644817283 3.4587864778920037 19.989096562729795 -6.961696242344213 0.41083008011956007 0.922312594593198 4.462999912612559 0.9998280266129018 0.013352505675049954 0.07910066814646179 0.018932872563075638 0.020497044469591247 0.13283437359502942 1.0922039872449749e-07 6.961696242344213 3.5406873180193608 NVDFNYATKDK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVDFNYATKDK 11 1 Q8WWM7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7-3;H3BUF6;Q8WWM7-7;H3BSK9;H3BSQ5;H3BUE3 Q8WWM7 ATXN2L Ataxin-2-like protein 1 5885700.0 1074800.0 1725800.0 3085100.0 True False 893743.8217132614 1716502.77285552 3730180.1461092834 1.0 1.9205758195509217 4.173656987030935 19.76950183816407 -6.955915682477828 0.4896206965688691 0.950523084506759 5.239187932146255 0.9995874230433813 0.027079211300751888 0.08119381795223923 0.02677849904088846 0.03241315487193438 0.1858272714315264 1.106838653928098e-07 6.955915682477828 4.288664847639495 NVDLLSDMVQEHDEPILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVDLLSDMVQEHDEPILK 18 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 33461700.0 11790000.0 7486700.0 14185000.0 False True 11415732.903519724 10476178.352624726 10469522.95912167 1.0 0.9176965194582196 0.9171135175993549 23.444520149471117 NVDPFHIYFCNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVDPFHIYFCNLK 13 0 Q7L0Y3;C9JVB6 Q7L0Y3 TRMT10C Mitochondrial ribonuclease P protein 1 0 9955900.0 3289700.0 3980000.0 2686200.0 False True 4312828.557500121 3386199.5139184864 2408257.7918498693 1.0 0.7851458662853169 0.5583940469096195 22.040202936878064 -6.9704436149129805 0.24736413257563178 1.0743344784693722 0.26258635309208384 0.9999856370934478 0.0006833095544953192 0.07615904818837327 0.008513658097876634 0.0051491000245769145 0.021826872008633626 1.0704253487768692e-07 6.9704436149129805 -0.8117481253772885 NVDPFHIYFCNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVDPFHIYFCNLK 13 0 Q7L0Y3;C9JVB6 Q7L0Y3 TRMT10C Mitochondrial ribonuclease P protein 1 0 16879700.0 3289700.0 4606900.0 8983100.0 False True 4505990.990799763 4403351.925018951 6861476.792751862 1.0 0.9772216442530892 1.522745342092667 22.103412998400955 -6.8971563350846585 0.9790743024588868 0.9755148497791502 1.5768112797802634 0.9850970827357249 0.03075926882004227 0.11352973008257458 0.1894631975645357 0.023682930540094002 0.06078491965941876 1.2671956252085328e-07 6.8971563350846585 0.6012964300011132 NVDSILEDYANYK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVDSILEDYANYKK 14 1 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;H0YLJ3;Q9UBU8-3;H0YM21;H0YMT8 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 1 13622800.0 5116500.0 5462500.0 3043800.0 True False 6707781.048256483 4647516.2926582275 2728856.7741912906 1.0 0.6928545012461657 0.40681959571423215 22.67740416732752 -7.138519338728143 0.2219073670548015 1.1389318887192708 7.051437982950367e-15 0.999986740522839 0.000881975910120734 0.08135264136636222 0.009126425173864326 0.010491699704288494 0.03299450884754944 7.269100298679123e-08 7.138519338728143 -1.1389318887192637 down NVDSILEDYANYK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVDSILEDYANYKK 14 1 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;H0YLJ3;Q9UBU8-3;H0YM21;H0YMT8 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 1 16844400.0 5995900.0 6435200.0 4413300.0 True False 5805563.436489728 9004808.919124663 3257324.333837969 1.0 1.5510654594740463 0.5610694585412154 22.46900465839322 -6.755631561086614 1.6289538452043069 1.3218225721971633 0.5582178618659769 0.6728698394914608 0.23165664880640136 0.29031755599674175 1.5172298688924182 0.11226421921975527 0.2709608560824639 1.7553690586519433e-07 6.755631561086614 -0.7636047103311864 NVDSILEDYANYKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVDSILEDYANYKK 14 1 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;H0YLJ3;Q9UBU8-3;H0YM21;H0YMT8 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 1 6379500.0 1723200.0 2152400.0 2503900.0 True False 2259131.8874925384 1831270.309989485 2244820.4471047954 1.0 0.8106079685423118 0.9936650708765712 21.107337066649805 -10.668326614364387 8.181968097393488 1.0001891819058564 0.9021365197144923 0.2759247154680602 0.07473274908522984 0.00025839470396140583 1.047461875919503e-05 0.07249864541569148 0.0241198910519494 2.14621578964405e-11 10.668326614364387 -0.0980526621913641 NVDSILEDYANYKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVDSILEDYANYKK 14 1 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;H0YLJ3;Q9UBU8-3;H0YM21;H0YMT8 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 1 9014100.0 3089800.0 2883900.0 3040400.0 True False 2991715.9902710076 4035456.3093398223 2244028.0299551315 1.0 1.348876805974576 0.7500805682266163 21.512541793053845 -6.7487568519900405 1.654340782026505 1.2054479869359889 0.7489948852206811 0.6436466108725569 0.14659250937378424 0.30221894597196475 1.6269648998434882 0.07000886785526887 0.170192019612232 1.783376945434536e-07 6.7487568519900405 -0.45645310171530773 NVESGEEELASK(ub)LDHYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVESGEEELASKLDHYK 17 1 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 116119000.0 26697000.0 47971000.0 41451000.0 True False 35000025.53411578 40813913.78949342 37162048.14606845 1.0 1.1661109718251674 1.061772029561672 25.06085263878139 -10.282525328785454 4.309736848593342 0.9999078373663067 1.1139415006954314 0.6139064987487041 0.04259619481465415 3.7751006124073774e-05 6.284711439612409e-06 0.04127691470297347 0.013747862759803943 5.217646731573242e-11 10.282525328785454 0.11403366332912468 NVESGEEELASK(ub)LDHYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVESGEEELASKLDHYK 17 1 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 284637000.0 48142000.0 59345000.0 177150000.0 True False 46613758.56159853 83041767.98008673 130749100.61391614 1.0 1.781486207990497 2.804946536142018 25.474252509196553 -6.96741435211454 0.31386545882891304 0.8493545092299281 3.769794166261854 0.9999546141730857 0.004979039424905043 0.07715094589302962 0.012018980277708166 0.015918255155310986 0.09052987528133989 1.0779178105703564e-07 6.96741435211454 2.920439657031926 NVESGEEELASK(ub)LDHYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVESGEEELASKLDHYK 17 1 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 487847000.0 133247000.0 181460000.0 173140000.0 True False 202145440.6605437 149077045.24654883 138918803.11004224 1.0 0.7374741906590369 0.6872220449598173 27.590818423452497 -13.999999999999998 0.23246876712139522 2.676407110371398 0.6633559545490219 0.9995132616244926 0.0030256753314571168 13.36940620154876 0.15264575882370887 10.359480990279577 0.025690603732657663 1.0000000000000041e-14 13.999999999999998 -2.0130511558223763 NVESGEEELASK(ub)LDHYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVESGEEELASKLDHYK 17 1 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 130785000.0 26697000.0 54693000.0 49395000.0 True False 36567602.359297566 52276482.41443519 37728918.321957774 1.0 1.4295846334356 1.0317580559766981 25.124062700304282 -10.590116661382421 7.321101325207924 0.9997697528339025 1.2306713447061133 0.3095204087641351 0.16241202014868625 0.0006109695274207724 3.420589536284027e-05 0.15740935853761825 0.05241825410498045 2.5697054086884184e-11 10.590116661382421 0.23090159187221082 NVESGEEELASK(ub)LDHYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVESGEEELASKLDHYK 17 1 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 206400000.0 48142000.0 82069000.0 76189000.0 True False 40032206.05221424 81626878.00757901 92119767.64186573 1.0 2.0390302223442944 2.3011414240252805 25.25465778463083 -10.51066799219643 0.29099704626004697 1.1107943701649682e-16 2.392463803621398 0.9990874506308635 0.016973133150458133 2.0957243247119504 0.1416908698804946 1.6353210049618239 0.09763617393723063 3.0855458752908e-11 10.51066799219643 2.392463803621398 NVESGEEELASK(ub)LDHYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVESGEEELASKLDHYK 17 1 Q96HS1;Q96HS1-2 Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5, mitochondrial 1 568067000.0 133247000.0 333340000.0 101480000.0 True False 172490868.19104415 314789335.97059 83011681.27273054 1.0 1.8249623256689833 0.48125261437486677 27.361944745544946 -6.740567218734462 1.6844904106459295 1.4905176286784225 0.4803444023735043 0.6075646964231074 0.3466097079586733 0.3167789298843497 1.7651165733033687 0.16276235553181406 0.39917575388914145 1.817325754360079e-07 6.740567218734462 -1.0101732263049183 NVESYTK(ub)LGNPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVESYTKLGNPTR 13 1 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 1 7429100.0 0.0 1357700.0 6071400.0 True False 0.0 1899836.6903119644 4481118.201904212 0.0 NVESYTK(ub)LGNPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVESYTKLGNPTR 13 1 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 1 5782300.0 0.0 1242000.0 4540300.0 True False 0.0 1235309.0994823012 5489655.738024699 0.0 NVFDEAILAALEPPEPK(ub)K(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVFDEAILAALEPPEPKKSR 20 2 P60953 P60953 CDC42 Cell division control protein 42 homolog 2 7965590.0 2812800.0 4568000.0 584790.0 True False 3687608.03919395 3886472.2059245408 524281.5405017824 1.0 1.053927685539502 0.14217387936283532 21.814253887249002 -6.892852613107607 1.0053320619950514 1.0456921105223849 0.05922056558315368 0.9826629751354663 0.05499527497309156 0.11686004014563957 0.2085612319726493 0.04151658150136267 0.10462543970789491 1.2798155625758411e-07 6.892852613107607 -0.9864715449392312 down NVFDEAILAALEPPEPK(ub)K(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVFDEAILAALEPPEPKKSR 20 2 P60953 P60953 CDC42 Cell division control protein 42 homolog 2 11893300.0 7152700.0 3637300.0 1103300.0 True False 6925641.453690026 5089692.858268916 814312.6317094762 1.0 0.7349056245984399 0.11757938050281325 22.723516269251327 -7.251178076525807 0.6023348285165979 1.0012336326721496 6.559283763604087e-24 0.99732565848618 0.019118134690375536 0.09376917460788549 0.0620598159983767 0.01839158793725196 0.056845083756456694 5.608179731241065e-08 7.251178076525807 -1.0012336326721496 down NVFDEAILAALEPPEPK(ub)K(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVFDEAILAALEPPEPKKSR 20 2 P60953 P60953 CDC42 Cell division control protein 42 homolog 2 15758900.0 7152700.0 5731500.0 2874700.0 True False 5947786.968336843 5700623.271886321 3475786.478888971 1.0 0.9584444268487922 0.5843831491262862 22.503921544685603 -6.92797091309976 0.7632678684013009 1.0061371967552197 0.5114142606345456 0.9961240965652326 0.011635815193766195 0.09370539448967975 0.08294401172168969 0.010475511773478418 0.0342315694639152 1.1803996903478535e-07 6.92797091309976 -0.4947229361206741 NVFDEAILAALEPPEPKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVFDEAILAALEPPEPKK 18 1 P60953 P60953 CDC42 Cell division control protein 42 homolog 1 10522770.0 3175500.0 5912270.0 1435000.0 True False 4163111.251585741 5030182.36184796 1286519.9654919845 1.0 1.2082747872596364 0.30902848560723556 21.989230681721704 -6.845725056616896 1.2554239157424558 1.1108681445324529 0.27591639835601284 0.9338608065614439 0.09884312591799213 0.16222923047884083 0.4941673569703874 0.061667536069542866 0.14237611729147676 1.4265104037663668e-07 6.845725056616896 -0.83495174617644 down NVFDEAILAALEPPEPKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVFDEAILAALEPPEPKK 18 1 P60953 P60953 CDC42 Cell division control protein 42 homolog 1 9537500.0 3175500.0 2654700.0 3707300.0 True False 4349568.164660797 2537406.576081052 2831712.094240186 1.0 0.5833697691409631 0.6510329271873861 22.052440743244595 -10.66510966694526 6.6645025706965155 1.0022443620363732 0.6172013481641877 0.9771036813642932 0.027623368599838403 0.0009254706882037653 4.650467913000756e-05 0.02687112184856968 0.008915403879443586 2.162172468456996e-11 10.66510966694526 -0.38504301387218554 NVFHIASQKNFK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVFHIASQKNFK 12 1 E5RGR5;A0A087WWE7;Q8N0T1-2;Q8N0T1 E5RGR5 C8orf59 Uncharacterized protein C8orf59 1 78582000.0 12062000.0 17145000.0 49375000.0 True False 11679098.41240498 23991087.909993865 36442206.2817506 1.0 2.0541900635507684 3.1202927653253973 23.477425571464018 -6.970985503350171 0.23345159710060448 0.5847151096972606 4.620356657612172 0.9999890817854 0.0028602066988313805 0.07598421777684543 0.007876678114578662 0.026709682789960037 0.10518843473695723 1.0690905646240059e-07 6.970985503350171 4.035641547914912 NVFHIASQKNFK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVFHIASQKNFK 12 1 E5RGR5;A0A087WWE7;Q8N0T1-2;Q8N0T1 E5RGR5 C8orf59 Uncharacterized protein C8orf59 1 59564000.0 15169000.0 15272000.0 29123000.0 True False 23012482.00244496 12546592.279319378 23366826.284935635 1.0 0.5452081300046803 1.0153979167676492 24.45591325748716 -10.85986129290566 12.067746391444684 1.0044736881115464 0.7803030233861649 0.22546597630212517 0.19195417663955036 0.023216419292868953 0.000269603907658879 0.1867612324444787 0.061952944113327926 1.3808252088879698e-11 10.85986129290566 -0.2241706647253815 NVFHIASQKNFK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVFHIASQKNFK 12 1 E5RGR5;A0A087WWE7;Q8N0T1-2;Q8N0T1 E5RGR5 C8orf59 Uncharacterized protein C8orf59 1 59729000.0 12062000.0 32659000.0 15008000.0 True False 10030087.437202597 32483059.484696094 18146103.410848327 1.0 3.238561945553254 1.8091670211709836 23.257830846898294 -10.30246257545629 6.095582404912598 0.9999146803178757 2.52386448336212 0.6024487363157702 0.5835480342767905 0.0006766548446140558 7.743222870491731e-05 0.5650487673445015 0.1883393182055062 4.983533988255833e-11 10.30246257545629 1.5239498030442444 NVFIGEK(ub)NYHCNNSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVFIGEKNYHCNNSEK 16 1 Q14586 Q14586 ZNF267 Zinc finger protein 267 1 5249850.0 798350.0 1610600.0 2840900.0 True False 1046644.5812323969 1370304.758069627 2546950.919837054 1.0 1.3092359934220732 2.4334439460223307 19.997340185475338 -6.947072150573168 0.5901120050744649 0.9870102034273001 2.812249274344884 0.9989510363758228 0.019948279897696312 0.08468314985592472 0.04099527301738889 0.020678720879472798 0.09418380283095053 1.1296082340657827e-07 6.947072150573168 1.825239070917584 up NVFIGEK(ub)NYHCNNSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVFIGEKNYHCNNSEK 16 1 Q14586 Q14586 ZNF267 Zinc finger protein 267 1 5199950.0 798350.0 1996200.0 2405400.0 True False 1093521.5695975272 1908001.2834493548 1837294.060768037 1.0 1.7448227236629623 1.680162615762812 20.06055024699823 -10.19018381318071 4.290053385986894 0.999761047653413 1.7124926697477436 0.9938609810015299 0.026397378628542436 9269463.690260319 9.761641706788788 21895.70661715865 0.009036524816387264 6.453810166162881e-11 10.19018381318071 0.7127316220943306 NVFIIGATNRPDIIDPAILRPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVFIIGATNRPDIIDPAILRPGR 23 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 19506600.0 3697500.0 10278300.0 5530800.0 False True 4847458.306640933 8744817.704499595 4958525.8711798405 1.0 1.8040006022371244 1.0229125363258404 22.20879705897939 -10.234445355635142 4.278309057519834 0.9997874344325653 1.4134565692906742 0.27198221822851365 0.3188778676806361 224921242.78096431 187.89011505905256 486029.07056108915 0.10916037575040875 5.828471059291169e-11 10.234445355635142 0.41366913485810886 NVFIIGATNRPDIIDPAILRPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVFIIGATNRPDIIDPAILRPGR 23 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 32273600.0 12233000.0 6951600.0 13089000.0 False True 11844670.111005656 9727410.132115088 9660598.238416873 1.0 0.8212478727522109 0.8156072012035676 23.49773468247362 NVFIIGATNRPDIIDPAILRPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVFIIGATNRPDIIDPAILRPGR 23 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 94330000.0 18180000.0 48346000.0 27804000.0 False True 27580389.136030715 39718278.57097791 22308527.2130739 1.0 1.4400913045527117 0.808854693929256 24.717139476417355 -6.7191899444998215 1.761830060633894 1.267964079404216 0.8098538182046944 0.5089318615624102 0.18520949684121676 0.35686339539386924 2.1643269674702297 0.08347676662627218 0.20978948949272988 1.909018141339793e-07 6.7191899444998215 -0.4581102611995216 NVFIIGATNRPDIIDPAILRPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVFIIGATNRPDIIDPAILRPGR 23 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 60804400.0 3697500.0 17911900.0 39195000.0 False True 5064565.671180382 17120493.03126765 29937948.246363696 1.0 3.3804464474991063 5.911256796752356 22.27200712050228 -6.97034826192725 0.24972921607977608 0.19415924160714387 9.171642401249999 0.9999849726823299 0.007773658689906684 0.07618986802251232 0.008624920856328789 0.05655019728860789 0.24266154369096163 1.0706603954169954e-07 6.97034826192725 8.977483159642855 NVFIIGATNRPDIIDPAILRPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVFIIGATNRPDIIDPAILRPGR 23 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 24012400.0 12233000.0 5125800.0 6653600.0 False True 10172281.513787054 5098186.298008362 8044836.997229508 1.0 0.5011841533385121 0.7908586668905985 23.278139957907896 -10.228234108220544 5.712089635512229 1.0000138223231925 0.6460214101145495 0.6656641150599879 0.11825912494861746 2.0817440559949674e-05 2.8128446195694227e-06 0.11450837198631125 0.03816796845525083 5.912428363842429e-11 10.228234108220544 -0.35399241220864297 NVFIIGATNRPDIIDPAILRPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVFIIGATNRPDIIDPAILRPGR 23 2 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 104139000.0 18180000.0 65343000.0 20616000.0 False True 23534368.381375816 61706604.60888668 16864099.538023364 1.0 2.6219783598577004 0.7165732797557871 24.488265798509804 -6.681203576921682 1.8974839197653244 2.0251229045125987 0.7237316830995221 0.3297043992006896 0.6872507501313809 0.4358505747676781 3.0349989471402115 0.2905066267258153 0.7650480343292071 2.0835140003327776e-07 6.681203576921682 -1.3013912214130765 NVFLLGFIPAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVFLLGFIPAK 11 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 34950000.0 10346000.0 13431000.0 11173000.0 False True 13563706.190806532 11427147.15362796 10016925.138983916 1.0 0.8424797022935567 0.738509445580101 23.693248103196716 -8.813239436357646 0.05165411943938176 1.7709443412161463 3.070982987545824e-08 0.9999977676634659 0.00016050700347354082 0.3345962799457989 0.01494450492287109 0.2694366833119712 0.2370681746677331 1.537306854629419e-09 8.813239436357646 -1.7709443105063165 NVFLLGFIPAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVFLLGFIPAK 11 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 17452100.0 4483100.0 6229900.0 6739100.0 False True 6801190.458511508 5118125.670569136 5407113.931147538 1.0 0.7525337956333715 0.7950246304866643 22.697355862491868 -10.266595201317887 5.521482083010694 1.000020186036458 0.7737792130600216 0.9742222581672823 0.017346810689267328 4.31090558371888e-06 5.725989491083979e-07 0.016797474886381968 0.005598659075774665 5.412585860506067e-11 10.266595201317887 -0.2262409729764363 NVFLLGFIPAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVFLLGFIPAK 11 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 43319400.0 10346000.0 9691400.0 23282000.0 False True 14171195.7901372 9263201.902825898 17783271.107841298 1.0 0.6536640972297381 1.2548885338397493 23.756458164719607 -6.750456840605419 1.647855983070164 0.7964724502665023 1.2561500768024205 0.651113671490148 0.14553622858070872 0.2992191700666211 1.5986983364026526 0.06975996559242649 0.16929699616275298 1.7764097958867334e-07 6.750456840605419 0.45967762653591826 NVFLLGFIPAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVFLLGFIPAK 11 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 35143900.0 25171000.0 3441300.0 6531600.0 False True 20930801.764369633 3422761.0338554317 7897327.361293759 1.0 0.16352746886562058 0.37730649070201067 24.31912423998699 -10.621539727145773 7.3346105379392865 1.0012224075187461 0.27041697983343654 0.9395021711982567 0.08727492020174309 0.0017467308216788176 9.012984018890986e-05 0.08460901890362449 0.028167859373577703 2.3903432683735578e-11 10.621539727145773 -0.7308054276853095 NVFLLGFIPAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVFLLGFIPAK 11 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 21772700.0 4483100.0 10463000.0 6826600.0 False True 5803461.325112532 9880724.852283807 5584228.846831127 1.0 1.7025571979825704 0.9622238409115006 22.468482184584317 -6.657980826080724 1.9797387545894214 1.4529633627137621 0.9652978879638318 0.22722259894671415 0.29927497948990617 0.4892237817719415 3.683749971370383 0.1222139553971645 0.3317583735208727 2.1979569095186935e-07 6.657980826080724 -0.4876654747499304 NVFVEFYAPWCGHCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVFVEFYAPWCGHCK 15 0 P07237;H7BZ94;H0Y3Z3 P07237 P4HB Protein disulfide-isomerase 0 5419400.0 1532500.0 2332800.0 1554100.0 False True 2009122.3407511099 1984755.3331831817 1393296.6399798542 1.0 0.9878718149344661 0.6934852157678814 20.938133985571103 -6.915565273604892 0.8569636115092937 1.007590247130133 0.6505374765186629 0.9928579280243633 0.011976894552480553 0.10085202179583563 0.11965224679448651 0.010083912852964724 0.029036575512836716 1.2146040541558167e-07 6.915565273604892 -0.3570527706114701 NVFVEFYAPWCGHCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVFVEFYAPWCGHCK 15 0 P07237;H7BZ94;H0Y3Z3 P07237 P4HB Protein disulfide-isomerase 0 38010400.0 19611000.0 6822400.0 11577000.0 False True 29751320.756143957 5604889.4163455 9288800.875620635 1.0 0.18839128058501511 0.3122147400364537 24.8264503798941 -10.135467630829256 5.502848063681138 1.0000131067526625 0.2503030103105802 0.9799506721736357 0.0505507156409141 8.128706406829346e-06 1.2770633180460821e-06 0.048946374461539544 0.01631517331793187 7.320358818286126e-11 10.135467630829256 -0.7497100964420823 NVFVEFYAPWCGHCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVFVEFYAPWCGHCK 15 0 P07237;H7BZ94;H0Y3Z3 P07237 P4HB Protein disulfide-isomerase 0 8211400.0 1532500.0 2403300.0 4275600.0 False True 2099106.66425529 2297114.259349681 3265791.338746074 1.0 1.0943294585578571 1.5558005671449262 21.001344047093994 -6.940293440184662 0.6568323046811142 0.994845116852909 1.6813244586346863 0.9982020317279228 0.01029726795927361 0.08763308327742012 0.05400284122491487 0.010046020951673883 0.03966683493633391 1.1473781094221738e-07 6.940293440184662 0.6864793417817773 NVFVEFYAPWCGHCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVFVEFYAPWCGHCK 15 0 P07237;H7BZ94;H0Y3Z3 P07237 P4HB Protein disulfide-isomerase 0 38427300.0 19611000.0 13580000.0 5236300.0 False True 25386826.090602864 12824261.062220616 4283347.128975158 1.0 0.5051541699798234 0.16872322336350162 24.59757670198655 -8.24320429398456 0.3153867470544132 1.1338658595636393 1.4380793443175809e-21 0.9987506757529346 0.012067586764502775 0.09781474649986979 0.0749663716684868 0.08146806365927228 0.09291195308219048 5.712098738918221e-09 8.24320429398456 -1.1338658595636393 down NVGLDIEAEVPAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVGLDIEAEVPAVK 14 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 20730600.0 5920600.0 4161000.0 10649000.0 False True 5732653.793772583 5822508.99932835 7859707.4368478395 1.0 1.0156742773570901 1.3710417059174038 22.450771723803033 -6.916141368587949 0.8528599296760485 0.9910166227851752 1.4235523414221414 0.9930400744320595 0.014293889019639601 0.10049566084259158 0.11777417334856499 0.012070308012160356 0.0349235440574732 1.212993940651166e-07 6.916141368587949 0.43253571863696616 NVGLDIEAEVPAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVGLDIEAEVPAVK 14 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 94614000.0 10460000.0 60558000.0 23596000.0 False True 15868584.728431296 49750951.75818642 18932240.257505797 1.0 3.1351851856737447 1.1930641945393805 23.919670128470187 -6.623527507639193 2.103548624349431 2.4132055924896205 1.200570146224744 0.09488028030935869 0.9173726736196195 0.5759919251306908 4.84783554368006 0.3577140434080997 1.017011428212806 2.3794275863810597e-07 6.623527507639193 -1.2126354462648765 NVGLDIEAEVPAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVGLDIEAEVPAVK 14 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 12284800.0 5920600.0 3192600.0 3171600.0 False True 4923241.227052037 3175400.8301185165 3834766.8961784705 1.0 0.6449817678383188 0.778911030218739 22.23117699923731 -10.040327886483698 5.6628291233431485 1.0000010592873407 0.711946399740571 0.8604883156094805 0.05467639241022106 7.312579772364117e-07 1.239142625848896e-07 0.05294038414985144 0.017646729769576205 9.11322543317198e-11 10.040327886483698 -0.2880546595467698 NVGLDIEAEVPAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVGLDIEAEVPAVK 14 0 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 0 42803000.0 10460000.0 19051000.0 13292000.0 False True 13540676.197425231 17990795.102825105 10872992.387437258 1.0 1.3286482034217808 0.8029874009914486 23.690796450562637 -6.737660325556801 1.695242445782254 1.1960727322622455 0.8028328071122557 0.5943949166141425 0.13809373023544658 0.32206945347402904 1.8164507726011707 0.06446655368566168 0.15860445906489107 1.8295305861965284e-07 6.737660325556801 -0.39323992514998984 NVGQFSGFPFEK(ub)GSVQYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVGQFSGFPFEKGSVQYK 18 1 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2 H0Y993 DEK Protein DEK 1 9368800.0 2925100.0 3702000.0 2741700.0 True False 3834834.426708695 3149676.0302829803 2458015.1842434616 1.0 0.8213329911576489 0.6409703551016388 21.870732858415362 -6.9710078859945925 0.2328595895245646 1.0707784063165724 0.38635363842568515 0.9999892101938969 0.0004814286056819181 0.07597703111301857 0.007850219954439566 0.004538241684307965 0.01781563388057626 1.0690354673148243e-07 6.9710078859945925 -0.6844247678908872 NVGQFSGFPFEK(ub)GSVQYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVGQFSGFPFEKGSVQYK 18 1 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2 H0Y993 DEK Protein DEK 1 15800900.0 5866000.0 5422100.0 4512800.0 True False 5679787.040886067 7587172.805877958 3330762.2989019575 1.0 1.3358199438221072 0.5864237998582332 22.43740540736095 -6.784880244929459 1.5167563707243226 1.188944617885773 0.5795424495330737 0.7843109062658347 0.14234026950779446 0.2430640566990665 1.1046973493578978 0.07389138140429875 0.1736626168049074 1.6410422220389378e-07 6.784880244929459 -0.6094021683526993 NVGQFSGFPFEK(ub)GSVQYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVGQFSGFPFEKGSVQYK 18 1 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2 H0Y993 DEK Protein DEK 1 15562200.0 5866000.0 5788100.0 3908100.0 True False 4877838.907861925 5756918.356452101 4725265.64098723 1.0 1.1802190406848632 0.9687211345522744 22.217810682795225 -6.68095932475485 1.8980216566968606 1.11392352570736 0.9695104977059129 0.3287572006277514 0.07636430063256566 0.43637536081571554 3.0400764203477064 0.03227073457046937 0.08502168776687762 2.084686121931415e-07 6.68095932475485 -0.14441302800144717 NVGQFSGFPFEK(ub)GSVQYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVGQFSGFPFEKGSVQYK 18 1 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2 H0Y993 DEK Protein DEK 1 26196300.0 8836700.0 9152700.0 8206900.0 True False 11439282.347398415 8643344.199130086 6713328.409905116 1.0 0.7555844795714657 0.5868662216762136 23.447493210530148 -7.772083855553022 0.10065029857423567 1.4731908145152581 1.2254016391570113e-14 0.9999938319214843 0.00042117808178960354 0.1335233066534758 0.01291965344064403 0.07994232654577788 0.10100538100987591 1.690114565132021e-08 7.772083855553022 -1.473190814515246 NVGSAGVTVVIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVGSAGVTVVIVR 13 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 3299500.0 1231100.0 2068400.0 0.0 False True 1613984.021989358 1759802.7825600505 0.0 1.0 1.0903470905436596 0.0 20.622194865715073 -6.965347619632614 1.1774443115797861 1.0549861074219669 1.4385668457298007e-20 0.9763732173416949 0.07594478913254402 0.10175769806790654 0.27918867655590945 0.05389124317835954 0.10117540680204072 1.0830596602705736e-07 6.965347619632614 -1.0549861074219669 down NVGSAGVTVVIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVGSAGVTVVIVR 13 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 5945400.0 2133900.0 1428500.0 2383000.0 False True 2066160.5125378042 1998907.49952909 1758820.8115323894 1.0 0.9674502476450345 0.8512508107959539 20.97852090564095 -6.9474903760008875 0.5857501835917593 1.0013611158161544 0.8115354998795928 0.9989893105165161 0.0020297781518891205 0.08450945970078004 0.04025596815948906 0.002113674916950543 0.009722466484322727 1.1285209453615957e-07 6.9474903760008875 -0.18982561593656155 NVGSAGVTVVIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVGSAGVTVVIVR 13 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 39911000.0 0.0 22797000.0 17114000.0 False True 0.0 18728697.23622605 13731410.398667337 0.0 NVGSAGVTVVIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVGSAGVTVVIVR 13 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 5187000.0 1231100.0 1718900.0 2237000.0 False True 1686270.9392265494 1642953.3143578265 1708666.6724611707 1.0 0.9743115866726663 1.013281218761259 20.685404927237965 -6.728910343664534 1.7270383114968342 0.9845220434542648 1.0132540881776402 0.5542436368674173 0.010799790779671942 0.3383031185314822 1.9762755882620389 0.004956376161358114 0.012314895852703952 1.8667650285353093e-07 6.728910343664534 0.028732044723375427 NVGSAGVTVVIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVGSAGVTVVIVR 13 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 4812800.0 2133900.0 1093200.0 1585700.0 False True 1774432.3977985927 1087310.7146167904 1917262.5385515846 1.0 0.6127653642740837 1.080493424787662 20.758926181075225 -6.6868544211102705 1.8774405678476083 0.7565173778225726 1.0788246501312742 0.35579071353714276 0.16387899778118245 0.4234776044174839 2.8914531404680646 0.06989189209879283 0.18273854234796041 2.0565798620267275e-07 6.6868544211102705 0.3223072723087016 NVGSAGVTVVIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVGSAGVTVVIVR 13 0 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 0 25665800.0 0.0 16024000.0 9641800.0 False True 0.0 15132250.313771952 7887091.333222431 0.0 NVHGINFVSPVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVHGINFVSPVR 12 0 P53634;H0YCY8 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 16503200.0 3728300.0 5318400.0 7456500.0 False True 4887837.404908561 4524915.450960832 6684972.907798589 1.0 0.925749994551114 1.3676749764804519 22.220764863680152 -6.863686449563725 1.1668919440084347 0.9592447468829023 1.390639990501522 0.9579702140577251 0.03961176115143068 0.14305670139207322 0.368058452508124 0.026432934121976556 0.0619848497051222 1.3687166502992378e-07 6.863686449563725 0.4313952436186198 NVHGINFVSPVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVHGINFVSPVR 12 0 P53634;H0YCY8 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 11290500.0 4318800.0 3115400.0 3856300.0 False True 4181702.0579915997 4359395.466596373 2846219.3434797903 1.0 1.0424930820370586 0.680636569513702 21.995658844362513 -6.877625470859964 1.0930044859037351 1.025591242312562 0.6561364736888344 0.971716928700938 0.027160293486652977 0.12975195311415508 0.2852001800233864 0.01918162671880035 0.04611706903271562 1.3254841203573454e-07 6.877625470859964 -0.3694547686237275 NVHGINFVSPVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVHGINFVSPVR 12 0 P53634;H0YCY8 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 7450800.0 4318800.0 1981400.0 1150600.0 False True 3591273.5552802696 1970725.8049228936 1391185.140226684 1.0 0.5487540212650536 0.38737932903529915 21.77606411979679 -13.999999999999998 0.14318206652985463 3.1623510943389572 0.195123651574133 0.9995905579072726 0.005246156224412684 11.9386147427901 0.11877674210118452 7.200929063630613 0.17226816584923624 1.0000000000000041e-14 13.999999999999998 -2.967227442764824 NVHMNDNVLHSAFEVGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVHMNDNVLHSAFEVGAR 18 0 Q13630;E9PKL9;E9PP14;A0A0J9YX13;E9PLH9 Q13630 TSTA3 GDP-L-fucose synthase 0 10898900.0 2304300.0 4374500.0 4220100.0 False True 3020959.6148729404 3721841.6516674417 3783444.534057648 1.0 1.2320064238342954 1.252398249692185 21.526575467123237 -12.625799601169556 0.3653044888827566 7.014491594449675e-22 1.254788032166138 0.9997198344653064 0.0019161470587409975 8.289534237525642 0.19275586712118778 6.275058645376864 0.005784367919957266 2.3670116684098565e-13 12.625799601169556 1.254788032166138 NVHMNDNVLHSAFEVGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVHMNDNVLHSAFEVGAR 18 0 Q13630;E9PKL9;E9PP14;A0A0J9YX13;E9PLH9 Q13630 TSTA3 GDP-L-fucose synthase 0 7594500.0 1886400.0 1331500.0 4376600.0 False True 1826517.2645631526 1863174.893680773 3230237.1648143725 1.0 1.0200696866264705 1.7685226564704535 20.80066395969639 -6.912650023525481 0.8774969064358581 0.9787225713718511 1.8709365334388353 0.9918835619980749 0.032221004545650835 0.1026920678097333 0.12945631115819806 0.02673027156654121 0.07521516496566634 1.222784644992142e-07 6.912650023525481 0.8922139620669841 NVHMNDNVLHSAFEVGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVHMNDNVLHSAFEVGAR 18 0 Q13630;E9PKL9;E9PP14;A0A0J9YX13;E9PLH9 Q13630 TSTA3 GDP-L-fucose synthase 0 8011000.0 2304300.0 2052100.0 3654600.0 False True 3156261.9813660444 1961431.4366127714 2791458.7488496173 1.0 0.6214412644427745 0.8844192165700584 21.58978552864613 -10.09736029346576 5.513320540988448 1.0000026078196733 0.7529302405063382 0.540630989352318 0.1073602993859269 3.4414236549528433e-06 5.634664418808006e-07 0.1039522602452123 0.03465038763042145 7.991709825849914e-11 10.09736029346576 -0.24707236731333515 NVICDK(ub)CEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVICDKCEGR 10 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 27553600.0 5601400.0 10839100.0 11113100.0 True False 7343489.644034762 9221948.530480888 9963223.016382547 1.0 1.2557992150192556 1.356742298190049 22.808034367508803 -13.262768143416858 0.13610942503667525 2.212255240650364e-15 1.4925494238341548 0.9996315852436459 0.002881869837606977 9.206520092839886 0.10875764853910881 2.5547720829705667 0.11608043433731319 5.460493023631544e-14 13.262768143416858 1.4925494238341526 NVICDK(ub)CEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVICDKCEGR 10 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 8837750.0 4156300.0 2873950.0 1807500.0 True False 4024360.531543598 4021533.222451255 1334061.526162313 1.0 0.9992974513416027 0.3314965236602735 21.94032812739269 -6.9071248958676374 0.9150756932999453 1.0226035513902025 0.2502941175057827 0.9897908739669712 0.03182464755904834 0.10635085131237156 0.14930180848018781 0.025690338444900325 0.0695820947472587 1.238440380463868e-07 6.9071248958676374 -0.7723094338844199 down NVICDK(ub)CEGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVICDKCEGR 10 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 51158700.0 10101000.0 16559300.0 24498400.0 True False 15323955.482015721 13604163.536598586 19656280.501969833 1.0 0.8877710165997615 1.282715844811645 23.869285403884685 -6.830801009365915 1.3245477734464215 0.9400672675596073 1.2935016688219931 0.907424824334887 0.050558431289936624 0.1798274235898714 0.6167762968517834 0.029969059578699976 0.0689580197575247 1.4763828464133392e-07 6.830801009365915 0.3534344012623858 NVICDK(ub)CEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVICDKCEGR 10 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 18511200.0 5601400.0 5841400.0 7068400.0 True False 7672388.952143286 5583307.633073371 5398989.498267565 1.0 0.7277143622279043 0.7036907972137354 22.871244429031695 -13.999999999999998 0.3437020797169789 4.2213480075204775 0.7000896715753204 0.9997425270286158 0.002156208388915045 20.04898219737918 0.1882968458740869 47.00993979966985 0.007325850787676752 1.0000000000000041e-14 13.999999999999998 -3.521258335945157 NVICDK(ub)CEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVICDKCEGR 10 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 16794520.0 4156300.0 1979120.0 10659100.0 True False 3456147.605309667 1968458.08773544 12887868.527890017 1.0 0.5695526674587928 3.7289693611726626 21.720733402826966 -6.872502782341051 1.1208298655131177 0.7524746775497956 3.922970961892588 0.96711496358118 0.253695480226714 0.1344747862512544 0.31422544057178775 0.1753882862710941 0.4171221205602747 1.3412113428040673e-07 6.872502782341051 3.1704962843427924 up NVICDK(ub)CEGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVICDKCEGR 10 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 40516600.0 10101000.0 13102000.0 17313600.0 True False 13075943.620477267 12372862.182416381 14162702.452537896 1.0 0.946230921571133 1.0831113121624918 23.640411725977135 -6.80018578735735 1.4554953481458306 0.970340124400667 1.085002095789001 0.832605250858863 0.023037609411329967 0.22049825157390707 0.9222410777921869 0.012452625197048943 0.028952533062258246 1.584215334102488e-07 6.80018578735735 0.114661971388334 NVIFEDEEK(ub)SK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVIFEDEEKSK 11 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2;B0QYS5 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 44077000.0 10481000.0 19177000.0 14419000.0 True False 15900443.263736924 15754714.51941513 11569078.329927796 1.0 0.9908349256744214 0.7275947052565899 23.922563648933824 -6.9142863152118 0.8660283972307693 1.0070876192538647 0.6902607568198018 0.9924412264306258 0.010981393739071517 0.10165152356194941 0.12389466031598632 0.009185679666185081 0.026177111947672776 1.2181862264248317e-07 6.9142863152118 -0.3168268624340629 NVIFEDEEK(ub)SK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVIFEDEEKSK 11 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2;B0QYS5 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 18442400.0 10481000.0 0.0 7961400.0 True False 13567861.111397104 0.0 6512506.890862408 1.0 0.0 0.47999510294160175 23.693689971026274 -10.09900254008366 6.334073880227018 1.000001492211953 0.23999755147079857 0.769727573108205 0.19595718020695058 4.1293546323611736e-06 5.869637319349826e-07 0.1897350969856839 0.06324490795927144 7.961546938869527e-11 10.09900254008366 -0.7600039407411543 NVIFEDEEKSK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVIFEDEEKSK 11 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2;B0QYS5 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 13825790.0 4883700.0 4410600.0 4531490.0 True False 6402577.993818079 3752555.6723841466 4062614.883921439 1.0 0.5861007356735638 0.634527980423517 22.610221491627076 -10.832447452533197 10.989062777860154 1.005616540029911 0.6103143581972424 0.9885498653379429 0.019770339881043486 0.0027050758749431695 4.124477264468738e-05 0.01903414197606841 0.006380849759011809 1.470796363665141e-11 10.832447452533197 -0.39530218183266863 NVIFEDEEKSK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVIFEDEEKSK 11 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2;B0QYS5 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 17751400.0 5949600.0 6091900.0 5709900.0 True False 5760733.204646393 8524427.438838828 4214305.896671746 1.0 1.4797469585925873 0.7315572075569554 22.45782101352451 -6.733509260306655 1.710251644472778 1.287569506108463 0.7316920234638048 0.5755578982857694 0.20162448170606656 0.32968724702948504 1.890695500551644 0.09336163429139403 0.23077206003542902 1.847101409403808e-07 6.733509260306655 -0.5558774826446583 NVIFEDEEKSK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVIFEDEEKSK 11 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2;B0QYS5 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 14349300.0 4883700.0 3190400.0 6275200.0 True False 6689335.867030062 3049437.578758049 4793127.001800773 1.0 0.455865520789277 0.7165325672201343 22.673431553149967 -10.435560192661756 6.129198943535653 1.0001436241987445 0.5861990440047096 0.7706463429806136 0.10641687608566205 0.00020892598520971437 1.9240108869385968e-05 0.10307303405476417 0.03434589906959891 3.6680885167864663e-11 10.435560192661756 -0.4139445801940349 NVIFEDEEKSK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVIFEDEEKSK 11 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2;B0QYS5 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 20749590.0 5949600.0 11112600.0 3687390.0 True False 4947356.011969877 11052734.21812159 4458406.200434962 1.0 2.2340689029413 0.9011694710564743 22.238226288958785 -6.663392461120919 1.9604035320985813 1.7920859860643177 0.9066233373567216 0.25039078776065715 0.5250071512723142 0.47639745989611615 3.522930966320063 0.2160769876796354 0.5824069307060062 2.17073864972879e-07 6.663392461120919 -0.8854626487075961 NVIFQPVAELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVIFQPVAELK 11 0 Q01813;Q01813-2;B1APP6;H0Y757 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 0 5257600.0 0.0 2062000.0 3195600.0 False True 0.0 1754357.637613048 2864949.9663597094 0.0 NVIFQPVAELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVIFQPVAELK 11 0 Q01813;Q01813-2;B1APP6;H0Y757 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 0 4235900.0 0.0 2072200.0 2163700.0 False True 0.0 1980643.3521509606 1652678.6228002845 0.0 NVIGLQMGTNR ddPTM_RPMI8226_Bortezomib_1h_R1 2 NVIGLQMGTNR 11 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 1193380700.0 322119700.0 277176000.0 594085000.0 False True 422302046.1116119 235822421.22358552 532614783.06571823 1.0 0.5584212139035174 1.2612176236649144 28.653699996311342 -6.736848972046368 1.69811688875077 0.7363078529505361 1.2613616516587418 0.5907467934364137 0.1855519586699924 0.32355628165434674 1.830684376583959 0.08648476135168465 0.21297385447512146 1.8329517291571249e-07 6.736848972046368 0.5250537987082057 NVIGLQMGTNR ddPTM_RPMI8226_Bortezomib_2h_R1 2 NVIGLQMGTNR 11 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 735504400.0 220132000.0 134605100.0 380767300.0 False True 213144030.15416497 188353618.38632348 281032921.35585254 1.0 0.883691737695347 1.3185118117199164 27.667253407233993 -6.835533302361477 1.3030319554649001 0.9380490390137208 1.3315894229134442 0.9164873465131291 0.0531158881696578 0.17408252404339827 0.5760807155246201 0.03198581285388429 0.07362202237441952 1.4603827607764743e-07 6.835533302361477 0.39354038389972334 NVIGLQMGTNR ddPTM_RPMI8226_Bortezomib_8h_R1 2 NVIGLQMGTNR 11 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 955073200.0 205124000.0 482605000.0 267344200.0 False True 311188104.5731109 396480367.13992494 214503501.68887433 1.0 1.2740858706145544 0.6893049526527729 28.21321167224632 -6.779240314414898 1.5386690338673448 1.1553478988073562 0.6847697811913724 0.764736003066411 0.11587207815728809 0.2517624391805806 1.1772351662870164 0.059314228459888964 0.14005525152686257 1.662492464926075e-07 6.779240314414898 -0.4705781176159838 NVIGLQMGTNR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NVIGLQMGTNR 11 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 904779700.0 322119700.0 252595000.0 330065000.0 False True 441216058.04757893 241434517.6800366 252110444.90205434 1.0 0.5472024720686872 0.5713990692398321 28.716910057834234 -10.454198335315361 6.041413405565356 1.0002221921939496 0.5593007706542609 0.9977441790739072 0.009878219430162906 2.9577570022143783e-05 2.6721506208234008e-06 0.009569275139889878 0.0031881816119335832 3.513999251761525e-11 10.454198335315361 -0.4409214215396887 NVIGLQMGTNR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NVIGLQMGTNR 11 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 508258800.0 220132000.0 141459500.0 146667300.0 False True 183049511.50110146 140697429.5959878 177334754.3170251 1.0 0.7686304565480426 0.9687802653106672 27.44765868266827 -10.178888298362564 6.577162835994756 1.0000005219892911 0.8687053610115353 0.3645748804602229 0.08171081726401086 6.254349765323436e-07 7.806175626872754e-08 0.07911647279614127 0.026372052872375935 6.623868493644871e-11 10.178888298362564 -0.13129516097775584 NVIGLQMGTNR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NVIGLQMGTNR 11 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 923544000.0 205124000.0 475793000.0 242627000.0 False True 265537061.5985327 449314701.2943396 198471375.56325176 1.0 1.6920978886693472 0.7474338021534711 27.98433799433877 -6.710323909417345 1.7940580971790003 1.4253419159721283 0.7496304481472258 0.46666159739226654 0.29163072023388653 0.37441172596286554 2.3493370402612586 0.12934956142275483 0.32847869340575797 1.9483908912944762e-07 6.710323909417345 -0.6757114678249025 NVIIWGNHSSTQYPDVNHAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVIIWGNHSSTQYPDVNHAK 20 0 P40925;P40925-3;A0A5K1VW95;P40925-2;B9A041;C9JF79;B8ZZ51 P40925 MDH1 Malate dehydrogenase, cytoplasmic;Malate dehydrogenase 0 178514000.0 41885000.0 42927000.0 93702000.0 False True 54911640.61491699 36522458.9281354 84006615.89305215 1.0 0.6651132349925439 1.529850773940114 25.71060868005838 -6.801697863880904 1.4489861292513226 0.8156251024525086 1.5422924399348517 0.837080539844601 0.1436956803234314 0.21834062872788645 0.9048505704592329 0.07801050105915439 0.18123801829332792 1.5787091864522906e-07 6.801697863880904 0.726667337482343 NVIIWGNHSSTQYPDVNHAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVIIWGNHSSTQYPDVNHAK 20 0 P40925;P40925-3;A0A5K1VW95;P40925-2;B9A041;C9JF79;B8ZZ51 P40925 MDH1 Malate dehydrogenase, cytoplasmic;Malate dehydrogenase 0 114707000.0 38078000.0 11688000.0 64941000.0 False True 36869234.73284342 16355079.352114791 47931003.91176031 1.0 0.4435969303573733 1.3000270892268608 25.135914136011056 -6.731358031211266 1.7183532041606362 0.6656681862136863 1.2996395217796126 0.5655413609455675 0.23387400709626077 0.3336861714861631 1.9308957441609544 0.10783158000629656 0.26715871257652857 1.856273517196731e-07 6.731358031211266 0.6339713355659263 NVIIWGNHSSTQYPDVNHAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVIIWGNHSSTQYPDVNHAK 20 0 P40925;P40925-3;A0A5K1VW95;P40925-2;B9A041;C9JF79;B8ZZ51 P40925 MDH1 Malate dehydrogenase, cytoplasmic;Malate dehydrogenase 0 172484000.0 41885000.0 56124000.0 74475000.0 False True 57371016.39956467 53644256.10275097 56885538.860771395 1.0 0.9350410620084121 0.9915379303128931 25.773818741581273 -10.317106346423639 4.448211214608204 1.000033661534835 0.963289496160445 0.36018470527982094 0.0230647499026062 7.706696847010033e-06 1.1831430230985322e-06 0.022352823810004634 0.007444116021332423 4.8182979670167705e-11 10.317106346423639 -0.03674416537439007 NVIIWGNHSSTQYPDVNHAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVIIWGNHSSTQYPDVNHAK 20 0 P40925;P40925-3;A0A5K1VW95;P40925-2;B9A041;C9JF79;B8ZZ51 P40925 MDH1 Malate dehydrogenase, cytoplasmic;Malate dehydrogenase 0 60440000.0 38078000.0 22362000.0 0.0 False True 31663544.141419403 22241531.467490554 0.0 1.0 0.702433415796818 0.0 24.916319411445333 -7.423833871078177 0.749345133566148 0.990946850875217 8.312624055895856e-18 0.9873333908434139 0.04718527393115645 0.11486108153153858 0.13968531516537488 0.04103510060327976 0.07372538938147788 3.768479255376906e-08 7.423833871078177 -0.990946850875217 down NVIVNGLVLASDGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVIVNGLVLASDGQK 15 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 5394600.0 1901400.0 1747100.0 1746100.0 False True 2492753.8131837924 1486439.4901424623 1565430.3217739053 1.0 0.5963041686190237 0.6279923486605795 21.249308977208987 -10.246591430460137 7.138557171823147 1.0000016233626294 0.6121482586398016 0.9950185516644476 0.012936645329876269 3.3423521496248164e-07 3.527220138803443e-08 0.012525905419310389 0.0041752843265335645 5.667722384350183e-11 10.246591430460137 -0.38785336472282783 NVIVNGLVLASDGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVIVNGLVLASDGQK 15 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 4954110.0 1343300.0 711710.0 2899100.0 False True 1300657.6767852453 995899.514518619 2139738.7388642672 1.0 0.7656891834753338 1.6451206009508408 20.310809874969614 -6.835817101734235 1.3016046564070933 0.8752078294008195 1.6717449846081014 0.9170364192206277 0.10710672937303567 0.17373802000284017 0.5735482579930433 0.06456469811760931 0.14862513191081658 1.4594287529762196e-07 6.835817101734235 0.7965371552072819 NVK(ub)DGLITPTIAPNGAQVLQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVKDGLITPTIAPNGAQVLQVK 22 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 1 394894400.0 1926500.0 247527900.0 145440000.0 True False 2525660.156252536 210597702.17619732 130391263.95899256 1.0 83.38323018433049 51.62660686402933 21.268229097652508 -9.524710096584418 8.296991744057935 1.0001333165076316 67.50491852418156 0.8539634253292513 12.964587181652346 0.0 0.0 12.552905129779393 4.184302520380819 2.987376108546998e-10 9.524710096584418 66.50478520767393 NVK(ub)DGLITPTIAPNGAQVLQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVKDGLITPTIAPNGAQVLQVK 22 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 1 1286962600.0 403935600.0 301239500.0 581787500.0 True False 391112885.481169 421526003.2932399 429399900.49911815 1.0 1.0777604598085664 1.0978924920124948 28.54300982652632 -13.99999999507524 0.1897216334425224 0.5835572809393518 1.1123759325195965 0.9994895444516719 0.0009536373656970737 12.345887235216376 0.13812454409319314 1.9004742615864603 0.013875432963223345 1.0000000113396773e-14 13.99999999507524 0.5288186515802448 NVK(ub)DGLITPTIAPNGAQVLQVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVKDGLITPTIAPNGAQVLQVK 22 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 1 2390644600.0 476624600.0 451787000.0 1462233000.0 True False 723074364.1256866 371162080.02205753 1173222006.630508 1.0 0.5133110762000977 1.6225468151524391 29.429568786964563 -6.78743502518782 1.506457364412307 0.7270764742421209 1.633542262433884 0.7929325117917517 0.20657953411864932 0.23920056941282325 1.072423331972186 0.10795071698029217 0.2532310845788733 1.631416967318473e-07 6.78743502518782 0.9064657881917632 NVK(ub)DGLITPTIAPNGAQVLQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVKDGLITPTIAPNGAQVLQVK 22 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 1 497390800.0 1926500.0 206514300.0 288950000.0 True False 2638779.111704936 197389815.3745339 220705961.1120498 1.0 74.80346289652066 83.63942253940685 21.3314391591754 -9.100890058236578 0.8470237712056276 1.5685822957308807e-20 81.7486568513653 0.9980936776567901 1.6176552690531396 0.6133650337851625 0.43890598281106286 6.3466042558405835 1.2635172850801537 7.927019777986235e-10 9.100890058236578 81.7486568513653 NVK(ub)DGLITPTIAPNGAQVLQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVKDGLITPTIAPNGAQVLQVK 22 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 1 1036260100.0 403935600.0 317161300.0 315163200.0 True False 335890348.78120536 315452689.1253114 381062367.9700071 1.0 0.9391537752422687 1.1344844213378285 28.323415101960595 -6.823004536343173 1.35873353215457 0.9672999534947477 1.1390331325430616 0.8911761945674633 0.02692202332914234 0.18960316601283148 0.6869543438573521 0.015566708694191397 0.03585488320286216 1.5031262653789437e-07 6.823004536343173 0.17173317904831387 NVK(ub)DGLITPTIAPNGAQVLQVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVKDGLITPTIAPNGAQVLQVK 22 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 1 1380305300.0 476624600.0 446046000.0 457634700.0 True False 616999940.3754617 421223147.99405354 374349880.32855403 1.0 0.6826956056717404 0.6067259586779727 29.200695109057012 -13.999999999999993 0.20080522931129124 2.7692780110654343 0.5577774071702954 0.9994869809579756 0.003858010055666975 12.546922795313884 0.14208589214248687 8.721853994463014 0.04808464533830406 1.0000000000000164e-14 13.999999999999993 -2.211500603895139 NVK(ub)DGLITPTIAPNGAQVLQVK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVKDGLITPTIAPNGAQVLQVKR 23 2 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 2 106653000.0 33875000.0 46642000.0 26136000.0 True False 44410453.04596667 39683195.40909204 23431697.434214998 1.0 0.8935552935705987 0.5276167169463958 25.40439595300892 -6.948355004160959 0.576620373082613 1.0044318674413868 0.39874500816929226 0.999065788984753 0.0061837721788778905 0.08415309938274221 0.03874848999883303 0.006502915379827414 0.03054127014715259 1.1262764307017322e-07 6.948355004160959 -0.6056868592720945 NVK(ub)DGLITPTIAPNGAQVLQVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVKDGLITPTIAPNGAQVLQVKR 23 2 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 2 181948000.0 65648000.0 56895000.0 59405000.0 True False 63564040.17389843 79613470.20350543 43845048.388200335 1.0 1.2524922894406805 0.6897775576921967 25.921707490496527 -6.78471184220918 1.5172785045740178 1.1420948038451544 0.6846253592483267 0.7837643899273925 0.10701305704576969 0.24333167690412472 1.1066489254762597 0.055531969225132594 0.13053868781817432 1.641678678574409e-07 6.78471184220918 -0.4574694445968277 NVK(ub)DGLITPTIAPNGAQVLQVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVKDGLITPTIAPNGAQVLQVKR 23 2 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 2 325075000.0 72232000.0 73673000.0 179170000.0 True False 109581224.86654386 60525477.54022372 143756970.9669991 1.0 0.552334376750544 1.3118759271223424 26.70742539396432 -6.747048219168762 1.6613319210089805 0.7358283668241601 1.3130006136524386 0.6359397278035495 0.18808916908410836 0.3052221354000003 1.656614000525562 0.08948213700746704 0.21786812366662314 1.790407056361271e-07 6.747048219168762 0.5771722468282785 NVK(ub)DGLITPTIAPNGAQVLQVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVKDGLITPTIAPNGAQVLQVKR 23 2 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 2 116970000.0 33875000.0 54475000.0 28620000.0 True False 46399502.93745385 52068114.375264786 21860545.447402183 1.0 1.1221696587019947 0.471137492073353 25.46760601453181 -6.858185911172933 1.194930389536109 1.0659867911329937 0.44069538957187077 0.9513932491064768 0.06229160240625796 0.14867866442181177 0.4044416235128884 0.040688938102230746 0.09479068486338002 1.3861623186169156e-07 6.858185911172933 -0.6252914015611228 down NVK(ub)DGLITPTIAPNGAQVLQVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVKDGLITPTIAPNGAQVLQVKR 23 2 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 2 180969000.0 65648000.0 73116000.0 42205000.0 True False 54589220.69950892 72722109.59561037 51029870.3661283 1.0 1.332169770217375 0.9347975609878484 25.702112765930803 -6.684908282129061 1.8843263965950368 1.2092326281842711 0.9362422932751276 0.34677995145399454 0.14063259912394888 0.42771071508054925 2.9402124785409334 0.05979319813600573 0.15672287998208567 2.0658163857945707e-07 6.684908282129061 -0.2729903349091435 NVK(ub)DGLITPTIAPNGAQVLQVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVKDGLITPTIAPNGAQVLQVKR 23 2 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 2 175052000.0 72232000.0 67203000.0 35617000.0 True False 93505747.90558498 63463093.97381521 29135071.461281456 1.0 0.6787079446484449 0.3115858876472476 26.47855171605677 -7.211307179758199 0.3096705056167419 1.0666944928244482 4.952878603046707e-12 0.9999014576019226 0.002791935217230066 0.09131894996948765 0.017454162356674185 0.00990723288151512 0.04144526376011856 6.147419073195097e-08 7.211307179758199 -1.0666944928194952 down NVK(ub)FVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVKFVLK 7 1 Q9UNL2-2;C9JA28;Q9UNL2;C9J365 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 100872000.0 21337000.0 23947000.0 55588000.0 True False 27973013.627801925 20374200.944674913 49836286.99774799 1.0 0.7283520186908043 1.781584482131611 24.737532352837146 -6.838241503778082 1.29044658497422 0.8554345382520218 1.815055977414662 0.9213991030363202 0.12516979628361163 0.17086592231605838 0.5534564237302163 0.07607766187642394 0.17520307353500075 1.451304347479489e-07 6.838241503778082 0.9596214391626402 NVK(ub)FVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVKFVLK 7 1 Q9UNL2-2;C9JA28;Q9UNL2;C9J365 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 77649500.0 15079000.0 9090500.0 53480000.0 True False 14600325.398827307 12720384.056331255 39471983.6343903 1.0 0.8712397641050488 2.7035002683954343 23.799497187155396 -6.890034514038937 1.0221447172333418 0.9016323250901167 2.861218210694752 0.9809215689644012 0.11534005496966292 0.11911649597413108 0.22166756163185253 0.08597282981259415 0.21436525357871228 1.2881471766220058e-07 6.890034514038937 1.959585885604635 up NVK(ub)FVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVKFVLK 7 1 Q9UNL2-2;C9JA28;Q9UNL2;C9J365 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 107940000.0 8821000.0 45031000.0 54088000.0 True False 13382101.9014811 36994866.22119112 43397483.092387445 1.0 2.7645034011508027 3.242949680990272 23.673801399375055 -9.880532819532586 0.33165952879810034 1.105578587465406e-22 3.3687553991586956 0.9987639674945902 0.03391092079791802 1.2474185869087437 0.14522084700960192 1.3953338087386535 0.15026070530970181 1.3166404107536015e-10 9.880532819532586 3.3687553991586956 NVK(ub)FVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVKFVLK 7 1 Q9UNL2-2;C9JA28;Q9UNL2;C9J365 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 87446000.0 21337000.0 12284000.0 53825000.0 True False 29225865.510743972 11741252.26224419 41112643.56067164 1.0 0.4017418152399246 1.4067211643589432 24.800742414360037 -6.745469801008191 1.6667590786103104 0.6463034341505217 1.40802861090222 0.6291584583473714 0.25135591827944836 0.30802944689210293 1.6821890464966103 0.11920779143181424 0.2907774034866078 1.7969260264253273e-07 6.745469801008191 0.7617251767516983 NVK(ub)FVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVKFVLK 7 1 Q9UNL2-2;C9JA28;Q9UNL2;C9J365 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 84862000.0 15079000.0 10425000.0 59358000.0 True False 12538856.612964531 10368838.455799514 71769483.35961717 1.0 0.8269365202787844 5.723766175411179 23.579902462589672 -6.898707817795452 0.9694154224784628 0.7891265291189589 6.224466695710169 0.9859119621056136 0.26927849811037496 0.11236218830980431 0.1828391904521668 0.20883121989589895 0.5398963819418748 1.2626767454704467e-07 6.898707817795452 5.43534016659121 up NVK(ub)FVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVKFVLK 7 1 Q9UNL2-2;C9JA28;Q9UNL2;C9J365 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 90030000.0 8821000.0 26355000.0 54854000.0 True False 11418958.387905147 24888321.082093053 44871134.84956992 1.0 2.179561413276935 3.9295295880136494 23.444927721467504 -6.965439544824537 0.350426524609606 0.8317144074706064 5.336465486102284 0.9999219217489789 0.010634429229807587 0.07781211722828396 0.014335781323889976 0.023995101461967087 0.1503721301978877 1.0828304380831764e-07 6.965439544824537 4.504751078631678 NVLCSACSGQGGK(ub)SGAVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVLCSACSGQGGKSGAVQK 19 1 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 30416730.0 5603970.0 6826300.0 17986460.0 True False 7346858.9389226725 5807842.648708997 16125393.657507293 1.0 0.7905205063812817 2.19486909869429 22.808696144196247 -6.868941938519569 1.139744727486108 0.8822622918326206 2.275454319427284 0.9636122799674999 0.11799793880131791 0.13786987032327527 0.3353983097260919 0.08040118257340385 0.1900021166516167 1.3522533358860532e-07 6.868941938519569 1.3931920275946634 up NVLCSACSGQGGK(ub)SGAVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVLCSACSGQGGKSGAVQK 19 1 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 18046700.0 6102000.0 4715400.0 7229300.0 True False 5908295.350065929 6598283.810486143 5335729.455648805 1.0 1.1167830007706903 0.9030911861217745 22.494310516182647 -6.758308099272204 1.6187254347656883 1.067977376055865 0.9023724970253276 0.6840377030814639 0.04910832021708922 0.28578444532571384 1.4754658322170455 0.023940497431427933 0.05763191756338498 1.7445840626218537e-07 6.758308099272204 -0.16560487903053744 NVLCSACSGQGGK(ub)SGAVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVLCSACSGQGGKSGAVQK 19 1 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 93441300.0 19743200.0 27700200.0 45997900.0 True False 29951877.821258616 22756882.887349572 36906394.90340427 1.0 0.7597815076288028 1.2321896851892746 24.836143119262058 -6.768524794606984 1.5806371735976703 0.8619537018211588 1.234665988019699 0.7246831949396562 0.1011996587529695 0.2688263032890804 1.3253665132887544 0.050478074858194596 0.12029590165271244 1.7040220310367012e-07 6.768524794606984 0.37271228619854024 NVLCSACSGQGGK(ub)SGAVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVLCSACSGQGGKSGAVQK 19 1 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 33019730.0 5603970.0 8156000.0 19259760.0 True False 7675909.150594921 7795640.951714716 14711001.355208183 1.0 1.015598386949449 1.916515824587112 22.87190620571914 -6.910657471859706 0.8912442545427494 0.9726804391662588 2.034596557179629 0.9911669194078502 0.04026486920679453 0.10398619617264648 0.13642206981678506 0.0330725380660641 0.09171659966372121 1.2284076945763948e-07 6.910657471859706 1.0619161180133703 NVLCSACSGQGGK(ub)SGAVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVLCSACSGQGGKSGAVQK 19 1 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 42539900.0 6102000.0 3266200.0 33171700.0 True False 5074083.364434611 3248604.3323100633 40107749.1013884 1.0 0.6402347180734672 7.904432430596749 22.274715791616924 -6.895248431376791 0.9907952908710208 0.6573622745801141 8.59750011473482 0.9840511404967807 0.42215897847883654 0.11498874051755968 0.19778895409726374 0.3221955179062445 0.8200174743603461 1.272774801785373e-07 6.895248431376791 7.940137840154705 up NVLCSACSGQGGK(ub)SGAVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVLCSACSGQGGKSGAVQK 19 1 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 74171900.0 19743200.0 25080700.0 29348000.0 True False 25557961.59665451 23684936.99729281 24006965.1359095 1.0 0.9267146328443159 0.9393145476457704 24.607269441354507 -10.101232386987787 6.905836973734222 1.0000000416138188 0.9330145902464287 0.9741498910909844 0.005143893677684215 3.2952347229572806e-09 4.352481863409583e-10 0.004980556717048105 0.0016601845456943663 7.920773837336608e-11 10.101232386987787 -0.06698545136739009 NVLINK(ub)DIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVLINKDIR 9 1 P27797;K7EJB9 P27797 CALR Calreticulin 1 11915900.0 1250500.0 4515900.0 6149500.0 True False 1897099.9237957282 3710002.3621122595 4934048.629578398 1.0 1.9556177909117543 2.600837503438578 20.855364239516852 -8.168730391054154 0.1565482596622739 3.1626087798340076e-14 3.7812279601687857 0.9999195302818767 0.005899185428862143 0.08864144049269865 0.03134520593785256 0.3213128227878101 0.35053296605161194 6.780623163963738e-09 8.168730391054154 3.781227960168754 NVLINK(ub)DIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVLINKDIR 9 1 P27797;K7EJB9 P27797 CALR Calreticulin 1 8815700.0 1250500.0 2222900.0 5342300.0 True False 1618796.9010401757 2099193.6609138586 4370056.216627004 1.0 1.2967616008932303 2.6995704117168597 20.6264905616093 -6.941064797827949 0.6495809185362383 0.9844975779875594 3.090016481038712 0.9983000821097712 0.030559975670084477 0.08728418690578484 0.052422375066123 0.029993583378700225 0.12018178641515012 1.1453420407860687e-07 6.941064797827949 2.1055189030511525 up NVLLDPQLVPGGGASEMAVAHALTEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVLLDPQLVPGGGASEMAVAHALTEK 26 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 18432200.0 7955700.0 3136500.0 7340000.0 False True 7703150.658230005 4388920.806631421 5417433.804719992 1.0 0.5697565842026368 0.703275068225757 22.87701721114657 -10.780486215135882 10.444965081682028 1.0018521309472987 0.6365158262141982 0.9081016899710104 0.05450869284776546 0.0023582686593174836 4.956181898027154e-05 0.052941724841551616 0.017592604968577577 1.6577299537262484e-11 10.780486215135882 -0.3653363047331005 NVLLDPQLVPGGGASEMAVAHALTEKSK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVLLDPQLVPGGGASEMAVAHALTEKSK 28 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 18499900.0 2506600.0 3944300.0 12049000.0 True False 2427029.3550434695 5519279.559252775 8893005.437748108 1.0 2.2740885056801967 3.6641524006572346 21.21076012738863 -6.97000879062472 0.2579775752971471 0.5999748787210063 5.379398615748125 0.9999824508038331 0.004557732456553541 0.07629987691931336 0.009020011508565545 0.029401407810756078 0.13155653533908007 1.0714976166618657e-07 6.97000879062472 4.779423737027118 NVLLDPQLVPGGGASEMAVAHALTEKSK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVLLDPQLVPGGGASEMAVAHALTEKSK 28 1 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 1 13066300.0 2506600.0 3092000.0 7467700.0 True False 2084348.961208094 3075342.782286055 9029161.54325639 1.0 1.475445253900085 4.331885740487076 20.991165402822908 -6.9358079621090765 0.6974812154636902 0.9644608788120141 5.0156082976574226 0.997561483041519 0.07266269241164199 0.08973251047202718 0.0637173365858998 0.06865817591671547 0.2507227169411111 1.1592898617830443e-07 6.9358079621090765 4.051147418845408 up NVLLQFIFLKPGSER ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVLLQFIFLKPGSER 15 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;Q8IWJ2 J3KNE0;Q8IWJ2 RGPD3;RGPD4;RGPD1;RGPD2;GCC2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;GRIP and coiled-coil domain-containing protein 2 0 4060800.0 2843400.0 0.0 1217400.0 False True 2753137.82339847 0.0 898526.4187828493 1.0 0.0 0.3263644889647077 21.392645403070386 -10.484227713380303 6.107729726616691 1.0005921519438707 0.16318224448238056 0.8976025027124901 0.13323774468795443 0.0010750256989279332 9.078156073664144e-05 0.1290891664099843 0.0430022971885569 3.279233081857877e-11 10.484227713380303 -0.8374099074614902 NVLLQFIFLKPGSER ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVLLQFIFLKPGSER 15 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;Q8IWJ2 J3KNE0;Q8IWJ2 RGPD3;RGPD4;RGPD1;RGPD2;GCC2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;GRIP and coiled-coil domain-containing protein 2 0 35892800.0 9697800.0 11668000.0 14527000.0 False True 14712271.604147313 9585754.237499898 11655732.08258972 1.0 0.6515482105970449 0.792245575408221 23.810516683001396 -10.240215151648611 5.021497478873835 1.0000425546930969 0.7218968930024497 0.8389509762360493 0.057439458657572794 2.7369022220464487e-05 4.141151168615394e-06 0.0556240133951234 0.01853850556623749 5.751549321295138e-11 10.240215151648611 -0.27814566169064714 NVLLQFIFLKPGSER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVLLQFIFLKPGSER 15 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;Q8IWJ2 J3KNE0;Q8IWJ2 RGPD3;RGPD4;RGPD1;RGPD2;GCC2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;GRIP and coiled-coil domain-containing protein 2 0 3486000.0 497300.0 1787700.0 1201000.0 False True 681165.2490271825 1708713.5028666493 917348.5353714195 1.0 2.508515379061068 1.3467341980254368 19.37764530943125 -6.580153783710101 2.2658351696507597 2.0271785062569334 1.3495934369224925 0.0 0.6553230568393068 0.6990814622184447 6.750689007084216 0.24279878400486474 0.732677962829868 2.629336778674241e-07 6.580153783710101 -0.677585069334441 NVLLQFIFLKPGSER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVLLQFIFLKPGSER 15 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;Q8IWJ2 J3KNE0;Q8IWJ2 RGPD3;RGPD4;RGPD1;RGPD2;GCC2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;GRIP and coiled-coil domain-containing protein 2 0 5611100.0 2843400.0 1209300.0 1558400.0 False True 2364413.083977937 1202785.2608727429 1884254.23477252 1.0 0.5087035209808398 0.7969226052506916 21.173050678504662 -10.257491766586579 5.75036077308034 1.0000186583466335 0.652813063115763 0.6592529721428462 0.11766494843224183 2.814751603304522e-05 3.6346488956666187e-06 0.1139347113830281 0.037976198809200105 5.527238864591695e-11 10.257491766586579 -0.34720559523087047 NVLLQFIFLKPGSER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVLLQFIFLKPGSER 15 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;Q8IWJ2 J3KNE0;Q8IWJ2 RGPD3;RGPD4;RGPD1;RGPD2;GCC2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;GRIP and coiled-coil domain-containing protein 2 0 30153100.0 9697800.0 9731300.0 10724000.0 False True 12553993.272217046 9189744.600499813 8772342.037532141 1.0 0.7320176457986022 0.698769056770646 23.581643005093845 -13.999999999999998 0.2943153366566259 3.3662914606065555 0.690096291044286 0.9996371215783034 0.0025687959995675585 16.227311044387324 0.17213855802718458 23.307342077740113 0.012317252731658101 1.0000000000000041e-14 13.999999999999998 -2.6761951695622694 NVMEEGK(ub)DFQPSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVMEEGKDFQPSR 13 1 P35606-2;P35606;H0YAC7 P35606-2 COPB2 Coatomer subunit beta 1 10993300.0 2743800.0 3905600.0 4343900.0 True False 4162545.1986491173 3208615.1654079203 3485326.261000996 1.0 0.7708301080908915 0.8373065263368429 21.98903450697664 -9.94447591034116 6.25564677790137 1.0000000488786045 0.8040683172138519 0.9205263104958822 0.027138884105125254 1.850605788105853e-08 3.1296498003161718e-09 0.026277118199925786 0.008759037181142208 1.1363813292748108e-10 9.94447591034116 -0.19593173166475264 NVMLLPVGSADDGAHSQNEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVMLLPVGSADDGAHSQNEK 20 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 17336400.0 6757000.0 2027700.0 8551700.0 False True 6542502.733594796 2837371.18431581 6311753.224499175 1.0 0.4336828427669313 0.9647306973353247 22.641411191385842 -10.674196214816075 9.780738532050385 1.0001957340676921 0.6992067700511284 0.2996057313785877 0.21679937878204875 0.000925917515326215 3.0842809349256424e-05 0.2100476115286475 0.069971698624249 2.1174042730835135e-11 10.674196214816075 -0.3009889640165637 NVMLLPVGSADDGAHSQNEK(ub)LNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVMLLPVGSADDGAHSQNEKLNR 23 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 1 9626800.0 1336300.0 1872600.0 6417900.0 True False 1293879.887953637 2620338.945479996 4736859.457127032 1.0 2.0251794388923137 3.6609730943563177 20.30327226617817 -6.964210287821572 0.3713627340977522 0.8761336595879956 4.867079902833237 0.9998959207913373 0.011179571044300255 0.07823005039259494 0.01581158232517542 0.02151735971277559 0.13882593483482983 1.0858996975811024e-07 6.964210287821572 3.9909462432452414 NVMLLPVGSADDGAHSQNEK(ub)LNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVMLLPVGSADDGAHSQNEKLNR 23 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 1 10133200.0 1336300.0 1717200.0 7079700.0 True False 1111192.6581274932 1707949.102762487 8560032.53716569 1.0 1.5370413854611022 7.703463908401337 20.083677541612445 -6.924040475372511 0.7941892323868854 0.882716464195192 8.796525754695828 0.9952316224594558 0.21001734409371517 0.0958522043605926 0.09372082080384544 0.18493807619184738 0.5773116123937445 1.1911309918406884e-07 6.924040475372511 7.9138092905006365 up NVNIFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVNIFK 6 0 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2 P00338 LDHA L-lactate dehydrogenase A chain 0 52191100.0 3253800.0 47082000.0 1855300.0 False True 4936252.484643379 38679849.24665495 1488599.1417931227 1.0 7.835873340552876 0.30156462750317903 22.234984758184886 -6.667855164553571 1.9450563645589947 5.371460700715044 0.3324233710034671 0.2694772618042408 2.9052020039178763 0.46610535079240323 3.3975839828282437 1.2033613845270459 3.2240049414059975 2.1485468863268558e-07 6.667855164553571 -5.039037329711577 NVNIFK(ub)FIIPNVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVNIFKFIIPNVVK 14 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2 P00338 LDHA L-lactate dehydrogenase A chain 1 32458000.0 4682200.0 11440100.0 16335700.0 True False 7103239.714671223 9398524.773090718 13106941.734808348 1.0 1.3231321411944963 1.8452061680724243 22.760045742429448 -6.963993709612738 0.37492777297792973 0.9620292847547858 2.2246230550567723 0.9998908667940473 0.0036377974126796217 0.07830419187422909 0.01607468501508451 0.006834098116934224 0.04422535142085226 1.0864413596848301e-07 6.963993709612738 1.2625937703019865 NVNIFK(ub)FIIPNVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVNIFKFIIPNVVK 14 1 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2 P00338 LDHA L-lactate dehydrogenase A chain 1 26230300.0 4682200.0 12184700.0 9363400.0 True False 6061200.199960269 11506610.73378789 7659357.276597212 1.0 1.8984046647829445 1.2636700692789224 22.531172064521897 -10.139706162539138 5.870046968636508 0.9999948210880122 1.5810373670309519 0.5276961978769849 0.25912931351285384 1.756319332855061e-05 2.5744518037443042e-06 0.25090311345376104 0.08363362631244411 7.249262689768455e-11 10.139706162539138 0.5810425459429397 NVNIFKFIIPNVVKYSPNCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVNIFKFIIPNVVKYSPNCK 20 2 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2 P00338 LDHA L-lactate dehydrogenase A chain 0 11319300.0 7067500.0 1355500.0 2896300.0 False True 9265560.941767365 1153264.6836976164 2596618.659271383 1.0 0.1244678752798356 0.2802440862016595 23.143446889711498 -9.889923883856358 6.0785124184393275 1.0000001094771114 0.20235598074138167 0.9721902818142547 0.06359537180483443 1.2292899867945136e-07 2.2491601285081593e-08 0.06157596498391695 0.020525317991177006 1.2884753551177714e-10 9.889923883856358 -0.7976441287357297 NVNIFKFIIPNVVKYSPNCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVNIFKFIIPNVVKYSPNCK 20 2 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2 P00338 LDHA L-lactate dehydrogenase A chain 0 22782900.0 7067500.0 12099000.0 3616400.0 False True 9680545.742006054 11564426.17395739 2762280.8020959212 1.0 1.1946047756147422 0.28534349981011575 23.20665695123439 -6.85072132983385 1.2315046497902076 1.1039234205858695 0.24846708247256902 0.9413550600225996 0.09466781864813283 0.15667224380165656 0.4568625584389283 0.06013797934244426 0.13923698800825274 1.4101933753525106e-07 6.85072132983385 -0.8554563381133005 down NVNLVLLCSEKPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVNLVLLCSEKPSK 14 1 Q96KR1;H0Y8W1 Q96KR1 ZFR Zinc finger RNA-binding protein 0 6670600.0 2171800.0 1369400.0 3129400.0 False True 2847250.831741115 1165090.857879391 2805599.7073244723 1.0 0.40919853105001264 0.9853714593908213 21.44113816383347 -10.936190432789822 10.448880263374772 1.0652071803150522 0.697284995220417 0.2690298988889809 0.23522161300669298 0.12568206721263858 0.0007675183339774749 0.08011095373831666 0.07591744915358066 1.1582693579174967e-11 10.936190432789822 -0.36792218509463526 NVNLVLLCSEKPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVNLVLLCSEKPSK 14 1 Q96KR1;H0Y8W1 Q96KR1 ZFR Zinc finger RNA-binding protein 0 6708100.0 2171800.0 1908800.0 2627500.0 False True 2974773.1506881807 1824462.9044425031 2006938.6150611192 1.0 0.6133116079861195 0.6746526586730945 21.504348225356363 -10.558498591262353 6.345972189779079 1.0005619738818547 0.643982133329622 0.978220059699194 0.02504237907821473 0.00019941018407169727 1.387330443996841e-05 0.02428381145280235 0.008082393093278217 2.7637668840923358e-11 10.558498591262353 -0.3565798405522328 NVNNEVHFFENNNFNTIANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVNNEVHFFENNNFNTIANK 20 0 Q9BY44;Q9BY44-3;F8WAE5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 8230600.0 1450100.0 3684200.0 3096300.0 False True 1901095.1427883746 3134531.7208991176 2775924.5778068514 1.0 1.6488031820972604 1.4601713061742647 20.858399304674226 -10.379051547455703 5.246478969320071 0.9996937341581374 1.554487244135784 0.9201344300064642 0.07700864087262921 0.0002760204456668656 3.2668633978177816e-05 0.07460344653602465 0.02485443196780263 4.177807762993806e-11 10.379051547455703 0.5547935099776465 NVNNEVHFFENNNFNTIANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVNNEVHFFENNNFNTIANK 20 0 Q9BY44;Q9BY44-3;F8WAE5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 8013700.0 2852300.0 0.0 5161400.0 False True 2761755.297770085 0.0 3809474.501319037 1.0 0.0 1.3793671381367163 21.39715406620722 -6.712237238790973 1.7870075878028937 0.38663314487231276 1.3763738479085383 0.47578112698758723 0.4212509322356179 0.37061830202243223 2.3083975114403024 0.18748548569259557 0.4750531445035799 1.9398259339442262e-07 6.712237238790973 0.9897407030362255 NVNNEVHFFENNNFNTIANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVNNEVHFFENNNFNTIANK 20 0 Q9BY44;Q9BY44-3;F8WAE5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 7772200.0 1450100.0 1915200.0 4406900.0 False True 1986241.1574790182 1830580.1312805328 3366080.9829544644 1.0 0.9216303490578889 1.6946990400837176 20.921609366197117 -6.881928843291319 1.0690269138847692 0.9500753350913909 1.7515437375200724 0.9752064589844208 0.054706591120180365 0.12593325030939512 0.2621013252002669 0.03935098811774128 0.09564110866672626 1.312414913207684e-07 6.881928843291319 0.8014684024286816 NVNSNLITWNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVNSNLITWNR 11 0 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 11074900.0 2392700.0 4160000.0 4522200.0 False True 3136852.8709397605 3539344.2155529945 4054286.124005468 1.0 1.12831055875842 1.2924693285952096 21.580886432792138 -6.967765888985977 0.30689571065447024 0.9737647483957101 1.4522099284478358 0.9999593358862313 0.0007632778628887417 0.07703448648755168 0.011611516493844289 0.0026345841662262165 0.014618689141955115 1.0770456499705968e-07 6.967765888985977 0.47844518005212566 NVNSNLITWNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVNSNLITWNR 11 0 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 6512190.0 2049300.0 635390.0 3827500.0 False True 1984246.0932301069 889104.5405150779 2824962.9274612726 1.0 0.44808178962707484 1.4236958495720573 20.920159534295564 -6.753216920267794 1.6377961833647041 0.6767272993512066 1.4261376735015532 0.6627476178511817 0.2319672236337641 0.29447043930574524 1.5549979654793977 0.111836442030259 0.2706133038112575 1.7651559450081636e-07 6.753216920267794 0.7494103741503466 NVNSNLITWNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVNSNLITWNR 11 0 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 8640400.0 2392700.0 2649900.0 3597800.0 False True 3277345.8502862216 2532818.6559525314 2748073.7390168966 1.0 0.7728261744885215 0.8385058716878776 21.64409649431503 -9.927405629475805 6.176888103635448 1.0000000460525125 0.8056660230881719 0.9210906502420338 0.02681362409991996 1.701022103299486e-08 2.943673228359556e-09 0.02596218608742632 0.008654059965856827 1.1819371150417696e-10 9.927405629475805 -0.19433402296434055 NVNSNLITWNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVNSNLITWNR 11 0 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 3364700.0 2049300.0 0.0 1315400.0 False True 1704083.749383129 0.0 1590444.0582775758 1.0 0.0 0.9333133179946759 20.70056480972984 -10.038948691323839 16.612254963879057 1.0000000035916894 0.4666566719857297 0.30333452956182083 0.38102356653848235 0.0 0.0 0.3689244819290241 0.12297482730967467 9.142212435584725e-11 10.038948691323839 -0.5333433316059597 NVNVFKFIIPQIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVNVFKFIIPQIVK 14 1 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 2642960.0 282120.0 422080.0 1938760.0 False True 369862.0520539659 359107.3092549535 1738155.7130991204 1.0 0.970922286459809 4.699470257753043 18.49662776159241 -6.905142856437662 0.9281910441075547 0.8660863226197427 5.134413262347283 0.9889555821925896 0.1840001192125613 0.10771783212666264 0.15684335962141208 0.14711534863883347 0.39365030259721606 1.244105309571765e-07 6.905142856437662 4.26832693972754 up NVNVFKFIIPQIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVNVFKFIIPQIVK 14 1 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;C9J7H8 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain;L-lactate dehydrogenase 0 2746070.0 282120.0 1543550.0 920400.0 False True 386427.3880063308 1475350.8571627345 703020.4762330177 1.0 3.817925185827056 1.8192822197724252 18.559837823115302 -9.335797879407295 9.55905831791538 1.0000131102263718 2.818603702799602 0.5247006831641731 0.8159425741746623 0.0 0.0 0.7900330002940988 0.2633443334313662 4.615323216644856e-10 9.335797879407295 1.8185905925732302 NVNVQNFHISWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVNVQNFHISWK 12 0 O43707 O43707 ACTN4 Alpha-actinin-4 0 115708000.0 38893000.0 57817000.0 18998000.0 False True 50989099.64034776 49190928.96890082 17032269.201684117 1.0 0.9647342140941818 0.3340374574530917 25.603685527459955 -6.918422462471383 0.8363521692942135 1.014723111837453 0.2359358482051909 0.9937311297454251 0.024225100766277187 0.09910905548795526 0.11049275161918864 0.02069983425138739 0.06110007662411733 1.2066394984706823e-07 6.918422462471383 -0.778787263632262 down NVNVQNFHISWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVNVQNFHISWK 12 0 O43707 O43707 ACTN4 Alpha-actinin-4 0 137581200.0 42331000.0 27929200.0 67321000.0 False True 40987225.57581794 39081475.2088539 49687610.513290755 1.0 0.9535037968491232 1.2122706481164207 25.28867100150125 -6.860414629948124 1.1835304125207182 0.9747422182969719 1.2249074400697775 0.9541496136184104 0.02411832650486554 0.14638099771228222 0.38936705157892093 0.015890546695711008 0.03711343621195693 1.3790670120237612e-07 6.860414629948124 0.25016522177280553 NVNVQNFHISWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVNVQNFHISWK 12 0 O43707 O43707 ACTN4 Alpha-actinin-4 0 80497000.0 12132000.0 17699000.0 50666000.0 False True 18405130.968004633 14540475.167081816 40651842.89230328 1.0 0.7900229122171903 2.208723369747936 24.133604679960055 -6.869262001959251 1.1380536427119436 0.8817686792138351 2.2906307315215355 0.9639379166859358 0.11872455752720101 0.13756120559298485 0.33345852333795517 0.0810010689273386 0.19152304897256375 1.3512571284101216e-07 6.869262001959251 1.4088620523077005 up NVNVQNFHISWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVNVQNFHISWK 12 0 O43707 O43707 ACTN4 Alpha-actinin-4 0 155223000.0 38893000.0 45967000.0 70363000.0 False True 53272793.1438049 43936025.94745834 53744708.57147308 1.0 0.8247366686566849 1.0088584697707568 25.666895588982847 -13.816083311493776 13.099421729901614 9.592448267566299 0.9251187600532298 0.0 0.08697912269176196 0.0 0.0 0.0 0.02517022557887931 1.527273050590929e-14 13.816083311493776 -8.667329507513069 NVNVQNFHISWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVNVQNFHISWK 12 0 O43707 O43707 ACTN4 Alpha-actinin-4 0 95729400.0 42331000.0 21355400.0 32043000.0 False True 35200102.08126544 21240354.221484993 38743043.14990755 1.0 0.6034174040872953 1.1006514430118022 25.069076276935526 -6.694218657059644 1.8510837518845673 0.7523659443217287 1.0990432777739958 0.3904235915687364 0.1675844575948179 0.407648161331352 2.7112413469024053 0.07233305137300718 0.1873885120682462 2.0220008924541454e-07 6.694218657059644 0.34667733345226714 NVNVQNFHISWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVNVQNFHISWK 12 0 O43707 O43707 ACTN4 Alpha-actinin-4 0 135055000.0 12132000.0 74188000.0 48735000.0 False True 15705113.157472555 70059372.58350681 39865730.063327916 1.0 4.460927589698536 2.5383917749334803 23.904731002052504 -9.487049730582662 8.428695036008122 1.000000001677711 3.49965968231609 0.692684806342716 0.7848719597336825 0.0 1.6950524474673464e-17 0.7599490072382987 0.25331633574609946 3.2579939193650113e-10 9.487049730582662 2.499659680638379 NVPNLHVMK(ub)AMQSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVPNLHVMKAMQSLK 15 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783;Q9NQ39 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 72838600.0 1339500.0 22609100.0 48890000.0 True False 2032119.4305672795 18574329.45929543 39226870.07075178 1.0 9.140372942603223 19.303427485953097 20.954553763178264 -7.2061825603860665 0.35199426384079735 1.4157881247590555e-15 26.372057632647863 0.9997031597803869 0.12900315034422039 0.11132116045505255 0.0258533743437769 0.2832773602331066 1.3286449345800524 6.220387494823336e-08 7.2061825603860665 26.372057632647863 NVPNLHVMK(ub)AMQSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVPNLHVMKAMQSLK 15 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783;Q9NQ39 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3;RPS10P5 40S ribosomal protein S10;Putative 40S ribosomal protein S10-like 1 65240400.0 1339500.0 24788900.0 39112000.0 True False 1734009.1554924587 23409375.923805587 31994017.323009834 1.0 13.500145515181737 18.45089296193683 20.725680085270714 -8.709915589427093 0.4861524574236328 6.555149852035192e-17 18.77495770257334 0.9954924480630702 0.4930069132548695 0.30837917238343177 0.1772890430116233 1.8593398947753856 1.0459764235814677 1.950223613313277e-09 8.709915589427093 18.77495770257334 NVPNWHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVPNWHR 7 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 8024240.0 628140.0 4460100.0 2936000.0 False True 823497.6229164136 3794670.465333631 2632210.8841006695 1.0 4.607992008398058 3.196379456177062 19.651404959954135 -9.645440020782182 10.14185225991587 1.0000000451256532 3.9021857322872857 0.8493030198919465 0.5762884112415526 0.0 0.0 0.5579888465230345 0.18599628494590523 2.2623509652717774e-10 9.645440020782182 2.9021856871616327 NVPNWHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVPNWHR 7 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 8822000.0 1989200.0 1794000.0 5038800.0 False True 1926053.9348330314 2510353.555586411 3718987.119240196 1.0 1.3033661779590988 1.9308842042175693 20.877216672519392 -6.959381152315749 0.44407652285761595 0.978492786570268 2.2803896491981943 0.9997465341296122 0.006171400134008745 0.07992303763774346 0.02195442218339473 0.008317231363105389 0.051955401675896 1.0980417358665315e-07 6.959381152315749 1.3018968626279264 NVPNWHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVPNWHR 7 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 7365940.0 628140.0 3631200.0 3106600.0 False True 860380.3328452329 3470761.5772273745 2372885.0624353434 1.0 4.033985255973654 2.7579489812236133 19.714615021477027 -9.21766294598756 12.088544058132143 0.9999393525362609 3.395962059772466 0.8245868976989004 0.5209396289297142 0.0 0.0 0.5043976262965452 0.16813254209884834 6.058108594626912e-10 9.21766294598756 2.396022707236205 NVPNWHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVPNWHR 7 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 3803540.0 1989200.0 1211100.0 603240.0 False True 1654107.9365016941 1204575.563915472 729374.6949333784 1.0 0.7282327454779359 0.44094746106831906 20.65762194795367 -6.97042270040895 0.2478900669747658 1.0935702727910257 0.06721830764232141 0.9999854916428091 0.0008694253646357754 0.07616583720239901 0.008538320589165534 0.006500240802771388 0.027629500253746685 1.0704768989467963e-07 6.97042270040895 -1.0263519651487043 down NVQDIK(ub)NVVLQTLEGHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVQDIKNVVLQTLEGHLR 18 1 E7EMK3;J3QLD9;Q14254 E7EMK3 FLOT2 Flotillin-2 1 54246100.0 19116500.0 18097400.0 17032200.0 True False 29001128.103351537 14867777.574368408 13665778.20452156 1.0 0.5126620427103387 0.47121540085684677 24.78960568436404 -13.999999999999998 0.34906437655249367 6.958692396151914 0.4654180888496888 0.9997529223642525 0.003774045975774549 20.567251965672984 0.19012453927435188 90.8318250994485 0.012405883704839697 1.0000000000000041e-14 13.999999999999998 -6.493274307302225 NVQDIK(ub)NVVLQTLEGHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVQDIKNVVLQTLEGHLR 18 1 E7EMK3;J3QLD9;Q14254 E7EMK3 FLOT2 Flotillin-2 1 35396000.0 19116500.0 10924600.0 5354900.0 True False 24746686.092550635 10316636.406504797 4380363.145913917 1.0 0.41688961374146816 0.17700807007175454 24.56073200645649 -10.102282366053807 0.21566897276350439 1.6396268275412371 4.650093318941601e-17 0.9993075447277432 0.009093976424867319 1.6340787722290888 0.10084425490711721 0.733990205568581 0.12904010774680028 7.901647180836326e-11 10.102282366053807 -1.6396268275412371 NVQGIIEILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVQGIIEILK 10 0 P42704;B8ZZ38;A0A0C4DG06 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 17651200.0 3921400.0 7222800.0 6507000.0 False True 5140993.374891616 6145186.394253881 5833718.059551458 1.0 1.1953305414215663 1.134745298066922 22.293615722237707 -10.062776507388536 4.264144536163224 0.9999836840102161 1.1650379197767902 0.9082064617412992 0.024733822135362443 8576712.518809747 0.13749607051224955 1401.178996361344 0.00846704518204823 8.654131551217825e-11 10.062776507388536 0.16505423576657408 NVQGIIEILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVQGIIEILK 10 0 P42704;B8ZZ38;A0A0C4DG06 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 17288300.0 3921400.0 4938100.0 8428800.0 False True 5371247.551850371 4719918.413887015 6438091.036585029 1.0 0.8787378292145599 1.1986211721645812 22.3568257837606 -6.803962508164572 1.439479214949522 0.9334274678065838 1.2034919156525188 0.8435614564684406 0.05215312938815724 0.21514075093410975 0.8796139142940763 0.028496003462748165 0.06612383970745003 1.5704983766874904e-07 6.803962508164572 0.270064447845935 NVQGIIEILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVQGIIEILK 10 0 P42704;B8ZZ38;A0A0C4DG06 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 4999000.0 0.0 1923400.0 3075600.0 False True 0.0 1913038.2624349936 3718693.740032319 0.0 NVQGIIEILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVQGIIEILK 10 0 P42704;B8ZZ38;A0A0C4DG06 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 9102500.0 2575300.0 4378300.0 2148900.0 False True 3333776.6167523153 4134643.7561649824 1757822.2495759807 1.0 1.240228195071106 0.5272765549865812 21.66872600757155 -6.815801169484497 1.3898029701155876 1.1300561875565631 0.5130518078946842 0.8744935348171272 0.1049256232218591 0.19898671239514604 0.7563123764379499 0.05934216883206687 0.13695990922948326 1.528265575033287e-07 6.815801169484497 -0.6170043796618789 NVQLYK(ub)MR ddPTM_RPMI8226_Bortezomib_1h_R1 2 NVQLYKMR 8 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 8215640.0 1803240.0 3455700.0 2956700.0 True False 2364065.1026010006 2940123.0302130943 2650769.04666909 1.0 1.2436726158591407 1.1212758243216954 21.17283833491845 -10.221760856007107 4.291265145504953 0.999916522201056 1.182474220096895 0.7476963362187065 0.04996828092520898 35201560.13459653 4.332986073446477 29035.89046261402 0.017105471635843524 6.001214417970903e-11 10.221760856007107 0.18255769789583898 NVQLYK(ub)MR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVQLYKMR 8 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 5406870.0 923670.0 1796100.0 2687100.0 True False 894348.6014413951 2513292.0965377614 1983267.898727938 1.0 2.8101929074268837 2.2175557668805697 19.770477752760634 -10.237753334589192 5.181007357519198 0.9998298295116268 2.5138743371541783 0.8969117741799311 0.24194309949499973 0.00047561999653166577 6.997455905429161e-05 0.23428574618568926 0.07808679958926826 5.7842448077916797e-11 10.237753334589192 1.5140445076425515 NVQLYK(ub)MR ddPTM_RPMI8226_Bortezomib_8h_R1 2 NVQLYKMR 8 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 234964800.0 15928600.0 11446200.0 207590000.0 True False 24164850.73664348 9403536.180431219 166559745.5100708 1.0 0.389141082761655 6.892645327103151 24.526406747652146 -6.883899139400561 1.0578422932927694 0.5977620638445278 7.389387985237677 0.9766957514087595 0.44765587697038306 0.12423104079475353 0.25190502643525126 0.32476120226830835 0.7937241530173333 1.306474268633355e-07 6.883899139400561 6.79162592139315 up NVQLYK(ub)MR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVQLYKMR 8 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 4069950.0 1040200.0 824150.0 2205600.0 True False 1424790.0503480278 787736.3279004022 1684682.7057578694 1.0 0.5528788804413569 1.182407685501705 20.442317916224688 -6.715961207214306 1.7739891332020046 0.7268086994577908 1.1812020298337647 0.49334096660455495 0.18824925116660568 0.363217988826409 2.231669980201625 0.08433407831743404 0.21271108834716126 1.9232635142318325e-07 6.715961207214306 0.45439333037597385 NVQLYK(ub)MR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVQLYKMR 8 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 8766370.0 923670.0 2785500.0 5057200.0 True False 768072.5305190617 2770493.958621541 6114637.138149126 1.0 3.607073353800646 7.961015262473803 19.55088302819491 -6.963411294290732 0.384344323896374 0.7151569078459019 11.007965822447058 0.9998765581795758 0.03190357008061164 0.07850428816952189 0.016786963642024123 0.05643482610631003 0.36715803855907486 1.0878993210344313e-07 6.963411294290732 10.292808914601157 NVQLYK(ub)MR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NVQLYKMR 8 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 205704500.0 15928600.0 52851900.0 136924000.0 True False 20619886.699647 49910645.30444607 112005236.95888202 1.0 2.4205101624200736 5.431903607928141 24.297533069744595 -6.958889864603342 0.4508063512779293 0.9036852354646422 7.0682703093508135 0.9997267855482608 0.030542071542236926 0.08010008894829829 0.022614707025388404 0.0402989543463415 0.24906241526970593 1.0992845783941335e-07 6.958889864603342 6.164585073886172 NVQVFLISGGFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVQVFLISGGFR 12 0 C9JBI3;P78330 C9JBI3 PSPH Phosphoserine phosphatase 0 25453300.0 12315000.0 6005300.0 7133000.0 False True 11924067.065890184 8403247.60722578 5264653.314586873 1.0 0.7047299852299548 0.44151490305240443 23.507373058990314 -7.0763847680977685 0.19861756132014038 1.1661902221154707 1.8388598627299092e-10 0.9999943962432508 0.0005399942057613821 0.07424436109867755 0.00685642961378011 0.009693457270423405 0.028691318624568894 8.387165868303414e-08 7.0763847680977685 -1.1661902219315847 down NVQVFLISGGFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVQVFLISGGFR 12 0 C9JBI3;P78330 C9JBI3 PSPH Phosphoserine phosphatase 0 88733000.0 19689000.0 39579000.0 29465000.0 False True 29869652.458707836 32515818.217861526 23641229.83503171 1.0 1.0885904435216238 0.7914799098420588 24.832177115820212 -6.826790860072068 1.3420884394940915 1.0474536719603642 0.7839913269103326 0.8993122654033848 0.03951984919215261 0.1848123021467299 0.6521375667040425 0.02312679290593579 0.05323631909775898 1.4900784708466643e-07 6.826790860072068 -0.26346234505003163 NVQVFLISGGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVQVFLISGGFR 12 0 C9JBI3;P78330 C9JBI3 PSPH Phosphoserine phosphatase 0 75586000.0 19689000.0 31768000.0 24129000.0 False True 25487798.62821277 30000082.87368366 19737769.584447313 1.0 1.1770370329462736 0.7744007190404951 24.60330343791266 -6.787201114429011 1.507668581351718 1.0993065688945305 0.7704520154400348 0.7920849710353836 0.07513298697149945 0.2395440156748863 1.0757349890257109 0.039233203178102555 0.09203857525829075 1.6322958842319942e-07 6.787201114429011 -0.32885455345449566 NVSIGIVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVSIGIVGK 9 0 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 0 80449000.0 24151000.0 18019000.0 38279000.0 False True 31662194.878616698 15330635.437511886 34318256.27809591 1.0 0.48419370470950973 1.0838874692566876 24.91625793329175 -6.679110319577426 1.9054206863907857 0.673379668319135 1.0815709177954838 0.31994914740752345 0.21865390097175402 0.44046807091546236 3.091179150075575 0.0921138167145347 0.24318809821799306 2.0935805765126922e-07 6.679110319577426 0.40819124947634877 NVSIGIVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVSIGIVGK 9 0 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 0 51080000.0 16947000.0 11420000.0 22713000.0 False True 16409026.761318782 15980065.554513263 16763783.924605608 1.0 0.9738582176112531 1.0216196346344624 23.96798633766053 -6.758109205394308 1.6197869317226827 0.9847795748419429 1.0217767979641723 0.683123016004042 0.01099245770154274 0.2861061219626513 1.4790698073191542 0.005355841088730475 0.012894058649320276 1.7453832129011593e-07 6.758109205394308 0.03699722312222942 NVSIGIVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVSIGIVGK 9 0 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 0 87522000.0 14013000.0 48643000.0 24866000.0 False True 21258745.48752462 39962276.60050634 19951224.200845044 1.0 1.8798040845805135 0.9384948990782699 24.34155312785723 -6.661428114680925 1.9681991681117674 1.565676978466905 0.9424448695243184 0.24147797118048975 0.37447824866269064 0.481107021433314 3.5843335315866054 0.1536514975317026 0.4150960628179472 2.180579301303225e-07 6.661428114680925 -0.6232321089425865 NVSIGIVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVSIGIVGK 9 0 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 0 71843000.0 24151000.0 14200000.0 33492000.0 False True 33080277.35623461 13572597.046879474 25581879.38939184 1.0 0.41029272217759866 0.7733272340466167 24.97946799481464 -10.645546172405103 5.1641063238912235 1.0060314971736528 0.5918099781121623 0.6276508088779822 0.1482082188499133 0.010390372017475894 0.0007131737486234592 0.1448754189626845 0.04783399694806435 2.2617980619087454e-11 10.645546172405103 -0.4142215190614905 NVSIGIVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVSIGIVGK 9 0 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 0 34028800.0 16947000.0 8338700.0 8743100.0 False True 14092181.379395816 8293777.767997634 10571241.786473066 1.0 0.5885375404069074 0.7501494269673027 23.748391613094807 -10.087527067226807 5.092780767371043 1.0000074533666032 0.669343483686198 0.8480575811470785 0.06597777641007609 5.5836455672744616e-06 1.0004240616229706e-06 0.06388414709732355 0.02129423577088243 8.174720877408212e-11 10.087527067226807 -0.33066396968040523 NVSIGIVGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVSIGIVGK 9 0 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 0 69169000.0 14013000.0 31445000.0 23711000.0 False True 18140104.737525776 29695058.107623488 19395841.29540514 1.0 1.6369838287754976 1.069224327866292 24.11267944994968 -10.259110337470426 4.130968652100405 0.9996954840101889 1.3531040783416357 0.3402482668721717 0.2317868457127991 163885402.65200603 250.7989762440391 478757.6415097806 0.0793468024454695 5.506677751979232e-11 10.259110337470426 0.3534085943314468 NVSLGNVLAVAYATQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVSLGNVLAVAYATQR 16 0 G3V1D3;G3V180;Q9NY33;Q9NY33-4 G3V1D3 DPP3 Dipeptidyl peptidase 3 0 8452300.0 1835100.0 4747100.0 1870100.0 False True 2405833.871133679 4038851.1840508683 1676599.9912658953 1.0 1.678773930532318 0.6968893452629987 21.198105593564506 -6.720744412900979 1.75679767362199 1.4126306572085268 0.6983718582663379 0.5159721415125464 0.2856043615452646 0.35386508832338914 2.134844920343502 0.12906829732557068 0.3237066418890177 1.9021974147661684e-07 6.720744412900979 -0.7142587989421889 NVSLGNVLAVAYATQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVSLGNVLAVAYATQR 16 0 G3V1D3;G3V180;Q9NY33;Q9NY33-4 G3V1D3 DPP3 Dipeptidyl peptidase 3 0 17394500.0 9771100.0 3728200.0 3895200.0 False True 9460921.778929735 5216889.702306159 2874930.2665048097 1.0 0.5514145264285568 0.30387422427564303 23.17354932171602 -9.241418253567167 0.17826109225419534 1.4852514895738917 2.595488987854758e-24 0.9996766171953787 0.005181138574025797 0.6749860999425693 0.06407907171658922 0.33453498474874077 0.15651316671538532 5.73563817223636e-10 9.241418253567167 -1.4852514895738917 NVSLGNVLAVAYATQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVSLGNVLAVAYATQR 16 0 G3V1D3;G3V180;Q9NY33;Q9NY33-4 G3V1D3 DPP3 Dipeptidyl peptidase 3 0 18246800.0 2609000.0 9225500.0 6412300.0 False True 3958043.7434490663 7579137.4458395 5144906.094389062 1.0 1.9148695509956613 1.2998608473957278 21.916356126153335 -10.42595344898806 5.385690025620619 0.9995081774114684 1.6073651991955817 0.565292460552179 0.2510762518650908 0.0014838742817280075 0.00015816234130663134 0.24329124992018303 0.08103451184180313 3.750131968806115e-11 10.42595344898806 0.6078570217841134 NVSLGNVLAVAYATQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVSLGNVLAVAYATQR 16 0 G3V1D3;G3V180;Q9NY33;Q9NY33-4 G3V1D3 DPP3 Dipeptidyl peptidase 3 0 14933500.0 1835100.0 4001000.0 9097400.0 False True 2513586.061712812 3824222.5904623126 6948781.486834269 1.0 1.5214209884090477 2.7644891864570647 21.261315655087397 -6.9564720309263235 0.48259791143345515 0.9708802423654662 3.3670843719712464 0.9996161278568195 0.014501682524061088 0.08098639256217513 0.02597783686128768 0.01762030823464306 0.10253434953245488 1.1054216575409422e-07 6.9564720309263235 2.3962041296057803 NVSLGNVLAVAYATQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVSLGNVLAVAYATQR 16 0 G3V1D3;G3V180;Q9NY33;Q9NY33-4 G3V1D3 DPP3 Dipeptidyl peptidase 3 0 16059000.0 9771100.0 2178400.0 4109500.0 False True 8125102.583124723 2166664.5268214564 4968777.449818842 1.0 0.26666303651617507 0.6115341189831436 22.953954597150297 -10.607484730640998 6.560706100244625 1.0014917952469533 0.4390985777521066 0.7791003049355005 0.1407930298475618 0.0030787555080279846 0.00018419603682500612 0.13661525543401898 0.04544075498847423 2.4689669097838884e-11 10.607484730640998 -0.5623932174948467 NVSQSQMAK(ub)LNQQMAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVSQSQMAKLNQQMAK 16 1 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 1 33344400.0 12900000.0 14676000.0 5768400.0 True False 19570243.11632541 12056953.135888634 4628273.21162046 1.0 0.61608601713439 0.23649543769640632 24.222158342533863 -7.57458381785585 0.33153680364732874 1.0720380387356587 3.3398544596947085e-13 0.9994279804405817 0.007454931231779462 0.12440174477257047 0.040610739340802414 0.024843339807849144 0.07012247654991678 2.663276040891483e-08 7.57458381785585 -1.0720380387353248 down NVSQSQMAK(ub)LNQQMAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVSQSQMAKLNQQMAK 16 1 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 1 11611900.0 5141200.0 3152600.0 3318100.0 True False 7042040.5757059045 3013307.707745933 2534433.1184145766 1.0 0.42790263352662866 0.3599003855726181 22.747562109249024 -13.999999999999998 0.30048572914852983 6.233087057875931 0.3432524344675381 0.9996509144107683 0.00536343646572175 16.62011573722446 0.17410296319956467 54.090101329983966 0.02452429191437736 1.0000000000000041e-14 13.999999999999998 -5.889834623408393 NVSVK(ub)DVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVSVKDVR 8 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 14073400.0 4201200.0 5112100.0 4760100.0 True False 5507813.884478677 4349394.606809728 4267570.51410341 1.0 0.7896771201849361 0.7748211184349673 22.39304837925526 -13.999999999999998 0.37628012656823184 4.047905989077277 0.7734300638965492 0.9998014515662044 0.0014489059033818375 23.572506774616077 0.19969423816320964 58.10919230664879 0.004072311751954184 1.0000000000000041e-14 13.999999999999998 -3.274475925180728 NVSVK(ub)DVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVSVKDVR 8 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 18909400.0 3121700.0 7831400.0 7956300.0 True False 3022603.342232191 10958518.860211486 5872306.346116291 1.0 3.6255233053896596 1.9427975427895863 21.52736023511029 -10.35397408907979 6.17022852627495 0.9998157935405954 2.7841604240896207 0.5998278979278501 0.6869699159009823 0.001740961143568353 0.00018228084880848473 0.665219829654033 0.22171858696916746 4.426147789014743e-11 10.35397408907979 1.7843446305490254 NVSVK(ub)DVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVSVKDVR 8 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 115224000.0 5266900.0 4027100.0 105930000.0 True False 7990272.3619669955 3308432.5411240915 84992889.06923161 1.0 0.4140575428782558 10.637045299455673 22.929813250019617 -6.893314672594185 1.0025849153073387 0.49355466314818686 11.575554434642624 0.9829359197667457 0.6122819731104434 0.11649425560581045 0.20647551048475266 0.46318773173728317 1.1693823487900352 1.2784546508453295e-07 6.893314672594185 11.081999771494438 up NVSVK(ub)DVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVSVKDVR 8 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 13786500.0 4201200.0 3354200.0 6231100.0 True False 5754497.173161066 3206000.3531438806 4759442.51353276 1.0 0.5571295382847077 0.8270822576350834 22.45625844077815 -10.301354326628344 6.033311997847743 1.0000187609163185 0.6921058979598954 0.6342980293617497 0.11020773618086349 2.7813166684908304e-05 3.2205706267344763e-06 0.1067146756878475 0.03556939390430851 4.9962673957085644e-11 10.301354326628344 -0.30791286295642306 NVSVK(ub)DVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVSVKDVR 8 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 21137300.0 3121700.0 12826000.0 5189600.0 True False 2595831.864758365 12756903.792238344 6274721.366000696 1.0 4.914379843097361 2.4172295021059784 21.307765510544566 -9.780532063335041 7.9252826127182905 0.9999999919290324 3.665804672601672 0.6030987747701926 1.0194573577409929 1.2031016580324893e-08 0.0 0.9870853495292259 0.32902844739162224 1.6575549574402393e-10 9.780532063335041 2.6658046806726396 NVSVK(ub)DVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVSVKDVR 8 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 51552400.0 5266900.0 3356500.0 42929000.0 True False 6818105.876120358 3169707.8243993693 35116362.48873714 1.0 0.4648956589983314 5.150457198344223 22.700939572112066 -6.878496273592075 1.0882003456082787 0.6745424897248434 5.473027705411726 0.9724499463863943 0.34758232146204554 0.12896813650115418 0.28043329325079774 0.24638068391570725 0.5935773690477233 1.3228290583257764e-07 6.878496273592075 4.798485215686882 up NVSVMTMIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVSVMTMIFK 10 0 A0A3B3IUB1;Q13144;A0A3B3ISX3;A0A3B3ITG6;A0A3B3ITK8;A0A3B3IST9;A0A3B3ISI2;A0A3B3ISS1;A0A3B3IS56;A0A3B3ISV1;A0A3B3IRP4;A0A3B3ITQ2;A0A3B3IUF2;A0A3B3ISM8 A0A3B3IUB1 EIF2B5 Translation initiation factor eIF-2B subunit epsilon 0 4310630.0 899630.0 2241600.0 1169400.0 False True 1179423.6420293117 1907162.0176883636 1048401.705676883 1.0 1.6170288179122032 0.8889102001321655 20.16965058829868 -6.682192394929946 1.8946006057791127 1.389647084130703 0.8916682599659722 0.33394014207267975 0.2613897187190882 0.43368455475134854 3.011753579988041 0.11064151034238161 0.29093884762279254 2.0787755736662152e-07 6.682192394929946 -0.4979788241647307 NVSVMTMIFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVSVMTMIFK 10 0 A0A3B3IUB1;Q13144;A0A3B3ISX3;A0A3B3ITG6;A0A3B3ITK8;A0A3B3IST9;A0A3B3ISI2;A0A3B3ISS1;A0A3B3IS56;A0A3B3ISV1;A0A3B3IRP4;A0A3B3ITQ2;A0A3B3IUF2;A0A3B3ISM8 A0A3B3IUB1 EIF2B5 Translation initiation factor eIF-2B subunit epsilon 0 4045230.0 899630.0 1280200.0 1865400.0 False True 1232247.522586614 1223636.5309447248 1424830.9391189383 1.0 0.9930119627071242 1.156286308555989 20.23286064982157 -6.896901766850622 0.9806562076018825 0.9926226211510845 1.1723854850218791 0.9849605511452024 0.009243665440185058 0.1137215907444869 0.19056448468539874 0.007108767590428174 0.01822422999698007 1.267938628698649e-07 6.896901766850622 0.17976286387079465 NVSVSWRPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVSVSWRPR 9 1 Q96EK9 Q96EK9 KTI12 Protein KTI12 homolog 0 10312100.0 3449700.0 3827800.0 3034600.0 False True 4522590.106942321 3256707.16064754 2720608.701938657 1.0 0.7200977943255105 0.6015598667149683 22.108717816348427 -13.999999999710985 0.11752038312740183 2.33688605722349 0.40588698694481273 0.9997051901720303 0.0028682455054285646 11.973985368403698 0.10517583219263557 3.7515306178291823 0.1736269922480469 1.0000000006654816e-14 13.999999999710985 -1.9309990702786775 NVSVSWRPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVSVSWRPR 9 1 Q96EK9 Q96EK9 KTI12 Protein KTI12 homolog 0 5942190.0 1365500.0 672190.0 3904500.0 False True 1322152.9499369098 940598.9724245426 2881794.3175107846 1.0 0.7114146456878729 2.1796224995363036 20.334457650369277 -6.855674945439627 1.207417080091646 0.8448975291926438 2.2450596662362217 0.9481634341509417 0.14460243078188975 0.15132065038045303 0.42168018278958047 0.093559863904875 0.21743744452367153 1.3941999234669361e-07 6.855674945439627 1.4001621370435777 up NVSVSWRPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVSVSWRPR 9 1 Q96EK9 Q96EK9 KTI12 Protein KTI12 homolog 0 5746100.0 1647300.0 1650300.0 2448500.0 False True 2499074.5337614594 1355791.071147249 1964552.9017843239 1.0 0.5425172610224603 0.78611216882251 21.25296249911394 -10.041234807639887 5.096823271316262 1.0000043578829383 0.6643147149209309 0.7168758022969588 0.09944720468048075 4.924652137063083e-06 9.264839715940826e-07 0.09629059136801107 0.03209644729542248 9.09421447730892e-11 10.041234807639887 -0.33568964296200743 NVSVSWRPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVSVSWRPR 9 1 Q96EK9 Q96EK9 KTI12 Protein KTI12 homolog 0 7133700.0 3449700.0 1375300.0 2308700.0 False True 4725147.3146371795 1314534.6984910804 1763432.6091690222 1.0 0.2781997281691136 0.37320161504941934 22.17192787787132 -10.758023402071055 7.067723478421858 1.0131410190447805 0.32570067160926647 0.9853309361331106 0.03878435790972612 0.00782914306640624 0.0002680448029171227 0.03660912945238924 0.012517597689809767 1.745728081374513e-11 10.758023402071055 -0.687440347435514 NVSVSWRPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVSVSWRPR 9 1 Q96EK9 Q96EK9 KTI12 Protein KTI12 homolog 0 2348700.0 1365500.0 983200.0 0.0 False True 1135473.7519068273 977903.3064500793 0.0 1.0 0.8612293369246657 0.0 20.114862925803553 -7.163494487003246 0.9249772530112745 0.9930294423455525 5.904591540753894e-17 0.9896260135105337 0.04505344060193371 0.08907650646697318 0.14435286094482433 0.037770690932886646 0.0663113709424916 6.862865901770788e-08 7.163494487003246 -0.9930294423455523 down NVSVSWRPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVSVSWRPR 9 1 Q96EK9 Q96EK9 KTI12 Protein KTI12 homolog 0 5059200.0 1647300.0 3411900.0 0.0 False True 2132462.3231375315 3222024.765698856 0.0 1.0 1.5109410050247598 0.0 21.02408882120639 -6.835700495990265 1.4394548479335887 1.2752915808606557 3.751774281333752e-21 0.8729585256448811 0.22366528086198698 0.1887403739308546 0.7848436467309984 0.12448566054032498 0.2677841891919743 1.4598206543946344e-07 6.835700495990265 -1.2752915808606557 down NVTDVVNTCHDAGISK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVTDVVNTCHDAGISKK 17 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 33524700.0 9956700.0 13316000.0 10252000.0 True False 13053330.120819954 11329304.70536146 9191221.384128097 1.0 0.8679244760148456 0.7041284713598237 23.637914573374964 -6.968225674948067 0.29753950579272426 1.0292512989846987 0.5376871896177261 0.9999650387438568 0.0007155455841804109 0.07688282967059352 0.011080440283267453 0.0027511472113229815 0.014728887514271361 1.0759059891074103e-07 6.968225674948067 -0.4915641093669726 NVTDVVNTCHDAGISK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVTDVVNTCHDAGISKK 17 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 31138200.0 9956700.0 9152500.0 12029000.0 True False 13637961.05970026 8748112.286729895 9187997.945031473 1.0 0.6414530917367324 0.6737075949118021 23.701124634897855 -9.93223098968247 5.791622347232786 1.0000002241010315 0.6575803437328729 0.993389349682871 0.013167845781884471 3.811295065615934e-08 7.019959243246312e-09 0.012749720213520811 0.0042499039514240595 1.1688775307931833e-10 9.93223098968247 -0.3424198803681586 NVTDVVNTCHDAGISKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVTDVVNTCHDAGISKK 17 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 8422800.0 2005800.0 3054400.0 3362600.0 True False 2629623.2241948275 2598695.42595795 3014670.4083368243 1.0 0.9882386959651425 1.1464267506459582 21.326424672444155 -6.888994725718066 1.028331413702285 0.9912943818845461 1.1597664034666004 0.9802462951013501 0.010113650635735967 0.11996173596797402 0.2266523878108949 0.007503584193274217 0.018639776849636507 1.2912349548992161e-07 6.888994725718066 0.16847202158205432 NVTDVVNTCHDAGISKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVTDVVNTCHDAGISKK 17 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 37475100.0 20025700.0 3504800.0 13944600.0 True False 19389995.115014 4904284.917290548 10292090.930967063 1.0 0.25292863088413453 0.5307938898343364 24.208809104193325 -10.381093767034141 5.883434604639777 1.0001389019432745 0.3918612603615792 0.8646212951590508 0.11343801694572095 0.00020672707459778555 2.1746659605735135e-05 0.10986058229902128 0.03661196253813065 4.1582082235186674e-11 10.381093767034141 -0.6082776415816953 NVTDVVNTCHDAGISKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVTDVVNTCHDAGISKK 17 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 63954800.0 8894600.0 42314200.0 12746000.0 True False 13493758.482361848 34762900.40764638 10226747.513229746 1.0 2.5762207359118037 0.7578872503607855 23.685788909357512 -6.677510775812948 1.9112219854067347 1.999536949948065 0.7650126498296006 0.3125915592841858 0.6684098486472703 0.4440527293435996 3.133956408786273 0.28088286594883555 0.7430472467478786 2.101305630329173e-07 6.677510775812948 -1.2345243001184645 NVTDVVNTCHDAGISKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVTDVVNTCHDAGISKK 17 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 7680200.0 2005800.0 2402000.0 3272400.0 True False 2747398.4647068563 2295871.6976482053 2499526.5171935307 1.0 0.8356529739464537 0.9097793965100096 21.389634733967046 -10.167821392983772 4.858296951907448 1.0000115292854548 0.872716185227789 0.7972147654989107 0.030261985291300583 42412815.92451265 0.6759737693940614 5470.177959589208 0.010359482486603615 6.79483017890689e-11 10.167821392983772 -0.12729534405766574 NVTDVVNTCHDAGISKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVTDVVNTCHDAGISKK 17 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 37695100.0 20025700.0 14478300.0 3191100.0 True False 16652256.838931223 14400302.524182476 3858344.2560206586 1.0 0.8647658190399805 0.23170098163512923 23.9892143796276 -6.941285021134041 0.6475007251267849 1.0069783493826778 0.05433171404642576 0.9983273863400195 0.01369606666126046 0.08718532297406545 0.051976963369496774 0.013465641083766324 0.054185599473475635 1.144761404648317e-07 6.941285021134041 -0.952646635336252 down NVTDVVNTCHDAGISKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVTDVVNTCHDAGISKK 17 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 52020200.0 8894600.0 34712000.0 8413600.0 True False 11514235.03877805 32780246.685699668 6882411.130826222 1.0 2.846932216973267 0.5977306445150192 23.456915231449962 -6.6885297362991984 1.8717153714445345 2.1595370023029132 0.6056731562319977 0.3634340487513136 0.7813638599647168 0.41988641311996167 2.850861402808109 0.3341093983823684 0.8716357382843068 2.048661772547579e-07 6.6885297362991984 -1.5538638460709155 NVTELNEPLSNEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVTELNEPLSNEER 14 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 61331100.0 2510100.0 34127000.0 24694000.0 False True 3290765.407842974 29035384.626004074 22138901.761574227 1.0 8.823292160785215 6.7275843209029595 21.64999175257622 -9.353459995294825 8.824248361667234 1.000000000793001 7.775438240844277 0.9330496701164803 0.8555691429467979 0.0 0.0 0.8284012605390588 0.27613375351301955 4.431390320234996e-10 9.353459995294825 6.775438240051276 NVTELNEPLSNEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVTELNEPLSNEER 14 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 47032900.0 10963000.0 4508900.0 31561000.0 False True 10614985.565842798 6309327.283602877 23294227.290295325 1.0 0.5943792617019856 2.19446622379329 23.33959907369306 -6.839505021912271 1.284716850491003 0.784208786976775 2.2465746280061083 0.923602146835456 0.1877261503299977 0.16937188684910862 0.543242728303822 0.11459021523247882 0.2639559668164044 1.447088119767876e-07 6.839505021912271 1.4623658410293334 up NVTELNEPLSNEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVTELNEPLSNEER 14 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 70500100.0 2510100.0 32322000.0 35668000.0 False True 3438151.802901925 30893907.16543929 27243953.005518526 1.0 8.985614637307087 7.9240110871555 21.71320181409911 -9.501197234213805 7.412421306829622 1.0000043628195812 8.45481286218339 0.9850184461485463 0.43339783452976466 0.0 0.0 0.4196356550936293 0.13987854961353266 3.153572107878483e-10 9.501197234213805 7.454808499363809 NVTELNEPLSNEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVTELNEPLSNEER 14 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 3526300.0 0.0 3526300.0 0.0 False True 0.0 3330058.305133178 0.0 0.0 NVTLCGHLHHGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVTLCGHLHHGK 12 0 Q15029-2;Q15029;Q15029-3;K7EIT3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 70893000.0 14108000.0 21627000.0 35158000.0 False True 18495724.62206635 18400335.901385706 31520187.419349976 1.0 0.994842661067367 1.7041877549228202 24.14068848741921 -6.905262888056628 0.9274067067374588 0.9746130244357186 1.7871402590400958 0.9890072421810512 0.034932659349481344 0.1076344422140964 0.1563826374112195 0.02794611472532382 0.07483102898237488 1.2437615075061528e-07 6.905262888056628 0.8125272346043771 NVTLCGHLHHGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVTLCGHLHHGK 12 0 Q15029-2;Q15029;Q15029-3;K7EIT3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 17734900.0 7528600.0 2506000.0 7700300.0 False True 7289608.713947292 3506658.8686173614 5683360.425951679 1.0 0.4810489844136669 0.7796523310061403 22.797409946071433 -10.214596661363172 5.684227658859419 1.0000126875730848 0.6303506577098961 0.6714078698506328 0.12190430577320457 1.9601364196290856e-05 2.708415281855049e-06 0.11803738477448744 0.039344445507544165 6.101032502329447e-11 10.214596661363172 -0.36966202986318875 NVTLCGHLHHGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVTLCGHLHHGK 12 0 Q15029-2;Q15029;Q15029-3;K7EIT3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 31227800.0 6184800.0 11735000.0 13308000.0 False True 9382793.769445695 9640797.564026525 10677667.966896385 1.0 1.0274975450724493 1.1380051857973628 23.1615861250293 -6.944766585233623 0.6136159449565372 0.998783379031638 1.1725100923713834 0.9987239382252535 0.0021304898968352785 0.0856577427159929 0.04520126509556558 0.0021582447687035246 0.00933030327181648 1.1356209995498512e-07 6.944766585233623 0.17372671333974532 NVTLCGHLHHGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVTLCGHLHHGK 12 0 Q15029-2;Q15029;Q15029-3;K7EIT3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 46954000.0 14108000.0 15695000.0 17151000.0 False True 19324108.854364537 15001543.003575604 13100287.03593272 1.0 0.7763122799935668 0.6779245104994269 24.203898548942103 -13.999999999999998 0.11151592416581614 2.0765945973965154 0.5013117945546394 0.9997353692322081 0.002192242042584449 12.003963222585023 0.1015792372579328 2.9017416979431045 0.1568152223734129 1.0000000000000041e-14 13.999999999999998 -1.5752828028418762 NVTLCGHLHHGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVTLCGHLHHGK 12 0 Q15029-2;Q15029;Q15029-3;K7EIT3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 15434900.0 7528600.0 1690900.0 6215400.0 False True 6260364.473530389 1681790.786082627 7515011.403237389 1.0 0.2686410341112647 1.200411163760801 22.57781522150571 -6.6974022740968 1.8403768152772149 0.5446888679464551 1.1974830533947134 0.4050977922545266 0.30886716283244814 0.40097799765859876 2.638560388858929 0.13399027497139332 0.34566574264681216 2.0072327111403387e-07 6.6974022740968 0.6527941854482583 NVTLCGHLHHGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVTLCGHLHHGK 12 0 Q15029-2;Q15029;Q15029-3;K7EIT3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 43094800.0 6184800.0 14695000.0 22215000.0 False True 8006345.520634385 13877210.332056837 18172097.945148863 1.0 1.733276473803403 2.269711930157742 22.932712447121748 -7.349979787061729 0.12311774286054929 1.8682733620870018e-19 3.815381782730698 0.9999966936197245 0.0009463037902337478 0.1180616458167549 0.008109541385492287 0.08965968941738077 0.15139895125801436 4.467043821871328e-08 7.349979787061729 3.815381782730698 NVTLPAVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVTLPAVFK 9 0 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 27434300.0 4582300.0 11361000.0 11491000.0 False True 6007439.67505632 9665983.084831148 10302021.549455322 1.0 1.609002105333755 1.7148772366754963 22.51831882563245 -11.423874181063724 0.30525799348246957 1.944778630611315e-10 1.743170475710433 0.9993708879183957 0.00790138161167649 3.734194288236021 0.1613396527362584 2.5178384547256516 0.03733316016832452 3.768129492022637e-12 11.423874181063724 1.7431704755159552 NVTLPAVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVTLPAVFK 9 0 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 27608700.0 10452000.0 5454700.0 11702000.0 False True 10120206.981135545 7632790.155884727 8636895.147524975 1.0 0.7542128505980699 0.8534306821613905 23.270735460924012 -10.057525184165534 5.493797058379065 1.0000013028228172 0.8038217664229662 0.8390388192021041 0.040505510119655204 6.463622155605172e-07 1.1089937027819124e-07 0.03921955216930788 0.013073097176864007 8.759409214989097e-11 10.057525184165534 -0.19617953639985097 NVTLPAVFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVTLPAVFK 9 0 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 58718300.0 4596500.0 51352000.0 2769800.0 False True 6973226.549161989 42187834.38499273 2222347.815953533 1.0 6.0499732925015435 0.3186972057032343 22.733394922602862 -6.67409573336009 1.9229867294791236 4.212083813917254 0.341561071537908 0.2971473018636389 2.143142265237858 0.45185528406510744 3.22517011934019 0.8960131229116113 2.3810951165271286 2.1178942274528368e-07 6.67409573336009 -3.8705227423793462 NVTLPAVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVTLPAVFK 9 0 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 31900300.0 4582300.0 11520000.0 15798000.0 False True 6276500.142001314 11011008.308454342 12066837.77002304 1.0 1.7543229601431014 1.9225424196637442 22.58152888715534 -11.031570555357307 0.2830261263099318 1.688297358271776e-10 1.9814861530531085 0.9992346097148205 0.011098447530021658 2.9666180832538926 0.14714917025909685 1.9897493044854446 0.06526319801846778 9.298854335604311e-12 11.031570555357307 1.9814861528842787 NVTLPAVFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVTLPAVFK 9 0 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 15364100.0 10452000.0 3078000.0 1834100.0 False True 8691301.102109237 3061418.203064838 2217601.8300797525 1.0 0.3522393445006619 0.25515188163732777 23.05114073635829 -13.999999999999998 0.2672368273738291 5.926304966921877 0.22205208024367573 0.9995774220113686 0.006796565873885539 14.74945162650363 0.16362408068112505 39.409780189013965 0.04088721228540668 1.0000000000000041e-14 13.999999999999998 -5.704252886678201 NVTLPAVFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVTLPAVFK 9 0 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 11478200.0 4596500.0 4207200.0 2674500.0 False True 5950259.8605607115 3973065.621573968 2187768.4426874025 1.0 0.6677129595478832 0.36767611733872113 22.50452124469531 -7.343290625374703 0.23511666968957212 1.1378269988149334 4.4116694498427775e-12 0.9999455254821928 0.0019061052169779666 0.11201638314272018 0.016620581530775308 0.01887484469425895 0.05133460696502406 4.5363794523438623e-08 7.343290625374703 -1.1378269988105219 down NVTLPAVFK(ub)APIRPDIVNFVHTNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVTLPAVFKAPIRPDIVNFVHTNLR 25 2 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 17034500.0 4544800.0 7274900.0 5214800.0 True False 4400527.811697745 10179805.508102313 3848887.4393533743 1.0 2.313314662173421 0.8746422256716644 22.06924514435832 -6.666553334889464 1.9501378179380906 1.8407674310328939 0.8806006398373049 0.2637163205637044 0.5583162313989168 0.46903067604605164 3.435648897686852 0.23078919143543328 0.6192724104849787 2.1549969761845346e-07 6.666553334889464 -0.960166791195589 NVTLPAVFK(ub)APIRPDIVNFVHTNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVTLPAVFKAPIRPDIVNFVHTNLR 25 2 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 14607400.0 4544800.0 3876400.0 6186200.0 True False 3779202.568777847 3855517.06379484 7479705.818242917 1.0 1.0201932798330184 1.9791756811442294 21.849650419792596 -6.911449491417965 0.8858145331869237 0.9716501235672 2.107024594420016 0.9914566301045278 0.04223166932495216 0.10346814260764912 0.1336302704189608 0.034825030200049255 0.09712514927248685 1.226169498276192e-07 6.911449491417965 1.135374470852816 NVTVQPDDPISFMQLTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVTVQPDDPISFMQLTAK 18 0 P53618 P53618 COPB1 Coatomer subunit beta 0 8069600.0 1214900.0 3742000.0 3112700.0 False True 1592745.6651083373 3183708.186201756 2790627.6631267546 1.0 1.998880459037509 1.7520861768830733 20.60308448026682 -10.154508194712037 5.470974200081457 0.9999792707388357 1.875483317960457 0.9437536498920909 0.10075334378638799 2.54753389374574e-05 3.936878915893695e-06 0.09755630876435252 0.03251800187986474 7.006349624443196e-11 10.154508194712037 0.8755040472216213 NVTVQPDDPISFMQLTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVTVQPDDPISFMQLTAK 18 0 P53618 P53618 COPB1 Coatomer subunit beta 0 8372100.0 1214900.0 3962200.0 3195000.0 False True 1664081.3614380134 3787136.9027567473 2440406.803090495 1.0 2.2758123433845197 1.4665189212753522 20.66629454178971 -10.27544674952311 5.473458293739625 0.999971420517414 1.8711656315881007 0.6070725215454394 0.33039265823497815 0.00038001059431652174 5.0305985508380706e-05 0.31993546715826526 0.10663377159347727 5.303386154514669e-11 10.27544674952311 0.8711942110706867 NVTWVIVNLCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVTWVIVNLCR 11 0 O00505 O00505 KPNA3 Importin subunit alpha-4 0 23032800.0 4463900.0 6785900.0 11783000.0 False True 6772062.654803479 5574903.126521305 9454084.885327645 1.0 0.8232208428501442 1.3960421465713677 22.69116389036578 -6.823821094476745 1.3551380831709936 0.9050668005379028 1.4096159262217416 0.8929769323531208 0.07834959344034123 0.18855786917837408 0.6793088943485278 0.04541996917383864 0.10460088596965611 1.500302750723089e-07 6.823821094476745 0.5045491256838388 NVTWVMVNLCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVTWVMVNLCR 11 0 O00629 O00629 KPNA4 Importin subunit alpha-3 0 54042000.0 15447000.0 16973000.0 21622000.0 False True 23434228.326967336 13944035.539345719 17348402.222740754 1.0 0.5950285772072718 0.7403018345936652 24.482113952854498 -10.119971411679018 5.595329515601124 1.0000039584565086 0.6676652059004156 0.8746522836789874 0.05930755897829833 2.928613417092582e-06 4.606334157956296e-07 0.05742498060481877 0.019141432352236542 7.58627511590439e-11 10.119971411679018 -0.332338752556093 NVTWVMVNLCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVTWVMVNLCR 11 0 O00629 O00629 KPNA4 Importin subunit alpha-3 0 30537000.0 15447000.0 0.0 15090000.0 False True 19996446.005891744 0.0 12343774.83647519 1.0 0.0 0.6172984355739127 24.253240274946947 -10.160525779382619 6.924965232984467 1.000001062597199 0.3086492177869564 0.6258072928336452 0.2520110310290673 4.134330763579377e-06 5.011698798424547e-07 0.24400900417938726 0.08133621051967813 6.909939113264828e-11 10.160525779382619 -0.6913518448102425 NVVDK(ub)SCPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVVDKSCPR 9 1 Q9BZQ6;Q9BZQ6-2 Q9BZQ6 EDEM3 ER degradation-enhancing alpha-mannosidase-like protein 3 1 1812650.0 315430.0 570180.0 927040.0 True False 413531.7846284648 485111.36654423276 831118.7935956015 1.0 1.1730933015948901 2.0098063183760235 18.65763869564366 -6.940562589829368 0.6543172144309646 0.9906914976032558 2.2392186622321635 0.9982365633120635 0.018516024592084967 0.08751106630749587 0.05344962257768756 0.018101644167025394 0.07183763796419974 1.1466672536545099e-07 6.940562589829368 1.2485271646289076 up NVVEELLSGNPHIEK(ub)ESAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVVEELLSGNPHIEKESAR 19 1 Q96BS2-3;Q96BS2 Q96BS2-3 TESC Calcineurin B homologous protein 3 1 16347500.0 2380500.0 4966200.0 9000800.0 True False 3611392.5378614436 4079942.8089022953 7221787.934809218 1.0 1.1297422714724645 1.999723890188282 21.784123810892222 -6.933530733748738 0.7172198281200313 0.9883458045415872 2.1955217144155106 0.9971878054932137 0.0235382416575797 0.09084543562250817 0.06900006023077787 0.02191408824819037 0.07724702697421483 1.1653845770650984e-07 6.933530733748738 1.2071759098739234 NVVEELLSGNPHIEK(ub)ESAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVVEELLSGNPHIEKESAR 19 1 Q96BS2-3;Q96BS2 Q96BS2-3 TESC Calcineurin B homologous protein 3 1 9532200.0 2949500.0 2919800.0 3662900.0 True False 2452639.935004897 2904070.457865076 4428795.454663928 1.0 1.184059028158684 1.8057259002655377 21.225904020866867 -6.948759883060017 0.5722948276611143 0.9923340621471984 2.0277952965523034 0.9991003484571246 0.010339860829353698 0.08398753699244237 0.03805272317085811 0.010925994172563899 0.05182661847899166 1.1252269283787558e-07 6.948759883060017 1.0354612344051048 NVVEELLSGNPHIEK(ub)ESAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVVEELLSGNPHIEKESAR 19 1 Q96BS2-3;Q96BS2 Q96BS2-3 TESC Calcineurin B homologous protein 3 1 23675700.0 2380500.0 6026200.0 15269000.0 True False 3081604.1766702454 5690836.672544459 12490198.673170302 1.0 1.8467124089549873 4.053148281576608 21.55525013298467 -6.954566615052679 0.5062342975346733 0.9581014490598092 5.03793980502372 0.9995126353074677 0.028411936114157023 0.08170220198872388 0.028762149300909937 0.032941809586944856 0.1820609895657593 1.1102822196048429e-07 6.954566615052679 4.079838355963911 NVVFVDMGHSAYQVSVCAFNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVVFVDMGHSAYQVSVCAFNR 21 0 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 0 97839000.0 27610000.0 27573000.0 42656000.0 False True 41886388.56137549 22652382.721167717 34225022.90321107 1.0 0.5408053427183278 0.8170917588911172 25.319978164811314 -10.298219031686529 5.906132338441505 1.0000230018815754 0.678948550804722 0.6429081212919603 0.11279345708093215 3.416513437523901e-05 4.059578108444076e-06 0.10921960923786515 0.036403931736300424 5.032467377698064e-11 10.298219031686529 -0.3210744510768534 NVVFVDMGHSAYQVSVCAFNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVVFVDMGHSAYQVSVCAFNR 21 0 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 0 68767000.0 27610000.0 25380000.0 15777000.0 False True 35741689.27446561 23967580.68918697 12905747.885690477 1.0 0.670577725219881 0.36108388125097746 25.091104486903763 -7.296096495402633 0.2458105722884248 1.1226113096471297 9.215726412917107e-13 0.9999468464923514 0.0019019653088111382 0.10523623210819814 0.015765630515697317 0.01580724625407602 0.04716412505490838 5.05712285875015e-08 7.296096495402633 -1.1226113096462083 down NVVHQLSVTLEDLYNGATR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVVHQLSVTLEDLYNGATR 19 0 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 83211000.0 16524000.0 32319000.0 34368000.0 False True 25068116.066214014 26551421.940500468 27575149.735970512 1.0 1.0591710151001577 1.100008858389458 24.579350242192003 -6.975077439427119 0.0619467460912306 0.7934380416987953 1.3667587707199262 0.9999999451078829 7.693810050883912e-06 0.07468687555463134 0.0017817086577744223 0.006720660515875776 0.009728545279668883 1.0590648655618391e-07 6.975077439427119 0.573320729021131 NVVHQLSVTLEDLYNGATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVVHQLSVTLEDLYNGATR 19 0 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 57932100.0 46967000.0 4273800.0 6691300.0 False True 39055141.49088834 4250776.191117115 8090419.892924393 1.0 0.10884037360634916 0.20715377243766758 25.219009151506665 -10.22435601235299 5.304238554821306 1.0000647310806088 0.15799707302186164 0.9898785806711045 0.0401362770031244 3.072615796294376e-05 4.4930946515867105e-06 0.03886474584357422 0.012953927700910141 5.965460682072341e-11 10.22435601235299 -0.8420676580587472 NVVHQLSVTLEDLYNGATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVVHQLSVTLEDLYNGATR 19 0 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 41052000.0 16524000.0 13561000.0 10967000.0 False True 21390643.7367356 12806318.428922929 8971118.530922692 1.0 0.598687846262886 0.419394509175803 24.350476564284453 -13.999999999994392 0.10900157604910053 2.9398585883180774 0.08570914654412726 0.9997481358704811 0.0038523199192627383 12.018596919494055 0.10002050690595474 5.140630184496592 0.2964601679169558 1.0000000000129129e-14 13.999999999994392 -2.8541494417739504 NVVTIFSAPNYCYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVVTIFSAPNYCYR 14 0 P67775;P67775-2;H0YC23;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0 53425000.0 18365000.0 18015000.0 17045000.0 False True 24076692.846912976 15327232.221920019 15281346.907185253 1.0 0.6366003968807211 0.6346945988117537 24.52113390261198 NVVTIFSAPNYCYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVVTIFSAPNYCYR 14 0 P67775;P67775-2;H0YC23;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0 21952300.0 14179000.0 3335700.0 4437600.0 False True 13728895.4061922 4667662.405445696 3275259.434853599 1.0 0.3399881976914487 0.23856685756206905 23.71071221860294 -13.999999999999998 0.26367963886791684 5.925722417882053 0.20278401128015616 0.9995699300744744 0.007000911127741535 14.582955317806503 0.16251025663446986 38.359680733312 0.043497030079902264 1.0000000000000041e-14 13.999999999999998 -5.722938406601897 NVVTIFSAPNYCYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NVVTIFSAPNYCYR 14 0 P67775;P67775-2;H0YC23;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0 57228000.0 11791000.0 26620000.0 18817000.0 False True 17887809.037565343 21869453.01699067 15097811.702215923 1.0 1.222589808011907 0.84402800088651 24.0924733560055 -6.74733474835663 1.6596843837720214 1.131295753726676 0.8434219941452559 0.6375429053487167 0.09352322840509235 0.30466107646897117 1.6502809192193286 0.0445304709581267 0.10841323160066545 1.7892262108538364e-07 6.74733474835663 -0.28787375958142003 NVVTIFSAPNYCYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVVTIFSAPNYCYR 14 0 P67775;P67775-2;H0YC23;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0 62912000.0 18365000.0 17818000.0 26729000.0 False True 25155036.795463882 17030741.843753424 20416160.701034676 1.0 0.6770310845589587 0.8116132314589279 24.58434396413487 -10.265813562291283 5.072422940908281 1.0000482600939071 0.7443221580088487 0.8279501896900014 0.0549429313992043 2.999162688116889e-05 4.340972735460882e-06 0.0532082889749153 0.01773275485836314 5.4223361520271515e-11 10.265813562291283 -0.2557261020850584 NVVTIFSAPNYCYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVVTIFSAPNYCYR 14 0 P67775;P67775-2;H0YC23;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0 24068100.0 14179000.0 0.0 9889100.0 False True 11790466.736204252 0.0 11956865.087967757 1.0 0.0 1.0141129571446528 23.491117494037216 -12.064990023495096 14.575881218092317 0.8819324384125774 0.5563508307151052 0.0 0.4885000841480193 0.0 0.0 0.0 0.14040670125976262 8.610135309462713e-13 12.064990023495096 -0.32558160769747224 NVVTIFSAPNYCYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NVVTIFSAPNYCYR 14 0 P67775;P67775-2;H0YC23;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0 43667000.0 11791000.0 21355000.0 10521000.0 False True 15263681.935357647 20166575.47744631 8606285.954576254 1.0 1.321213031223569 0.563840755528335 23.86359967809795 -6.79145753105164 1.4903375156344136 1.1791859156714843 0.5554396254909012 0.8060670540841135 0.13668487755893924 0.2331818080324667 1.0231072117032993 0.0721812349753588 0.16882849069743505 1.6163762811761667e-07 6.79145753105164 -0.6237462901805831 NVVVFDK(ub)SSEQILATLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVVVFDKSSEQILATLK 17 1 Q9UMS4 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 1 5816000.0 0.0 2890200.0 2925800.0 True False 0.0 4044271.932193886 2159445.2078814367 0.0 NVWSFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NVWSFLK 7 0 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3;O94979-5;H0Y8V7;H0Y9K1 D6REX3 SEC31A Protein transport protein Sec31A 0 13895300.0 2895500.0 4038900.0 6960900.0 False True 3796028.540061889 3436311.86350889 6240652.841667694 1.0 0.9052386796472467 1.6439952376032316 21.856059408482714 -6.874676208369498 1.1090207993297563 0.9445425390369021 1.6912941704725242 0.9691333810625268 0.0576621253131322 0.13245234016171575 0.30165091604744737 0.0402244716233835 0.09608903570974803 1.3345160201593844e-07 6.874676208369498 0.7467516314356221 NVWSFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVWSFLK 7 0 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3;O94979-5;H0Y8V7;H0Y9K1 D6REX3 SEC31A Protein transport protein Sec31A 0 13405600.0 3064500.0 1764900.0 8576200.0 False True 2967219.124922489 2469633.773831913 6329835.939514928 1.0 0.8323058290804276 2.133255305059507 21.500680041058374 -6.874503748425448 1.1099462268699887 0.9020044408978793 2.216278408038081 0.9689773686391494 0.10177241277563677 0.13261238607929887 0.30262797860950225 0.0709446585967536 0.16941445405315533 1.335046066638515e-07 6.874503748425448 1.3142739671402017 up NVWSFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVWSFLK 7 0 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3;O94979-5;H0Y8V7;H0Y9K1 D6REX3 SEC31A Protein transport protein Sec31A 0 14141000.0 2895500.0 5421500.0 5824000.0 False True 3966044.597945317 5181960.203496983 4448491.149045078 1.0 1.3065814252773642 1.121644257694354 21.919269470005606 -10.173314549546111 3.82428531544944 0.9998535610712443 1.214112841608455 0.6412183675970555 0.07550028293915742 22561895.828147884 27701300.950476483 36748.664488025206 0.027630277316206462 6.709427284519245e-11 10.173314549546111 0.21425928053721066 NVWSFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVWSFLK 7 0 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3;O94979-5;H0Y8V7;H0Y9K1 D6REX3 SEC31A Protein transport protein Sec31A 0 7576600.0 3064500.0 2431600.0 2080500.0 False True 2548267.5303687076 2418500.4881651895 2515522.9308548747 1.0 0.949076366332407 0.9871502504648344 21.28108531649265 -10.091898060518346 4.811014209644241 1.0000013636975635 0.968113308398513 0.48325681616206917 0.015543598109505743 2.2737341877194354e-07 4.2912282392822036e-08 0.015050667925181106 0.005016674718028398 8.092858359624251e-11 10.091898060518346 -0.03188805529905059 NVYK(ub)FELDTSER ddPTM_RPMI8226_Bortezomib_2h_R1 1 NVYKFELDTSER 12 1 P04844;P04844-2 P04844 RPN2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 1 41873300.0 1265800.0 4597500.0 36010000.0 True False 1225617.8718638897 6433305.725645777 26577900.723156232 1.0 5.249030610056431 21.685307740117405 20.225077809119245 -6.945644642767258 0.6047732843986214 0.8166401494172378 26.966002259314013 0.9988136458892447 0.3072337615312569 0.08528322311576307 0.043573843826874396 0.31386108974194044 1.3834532362142233 1.1333273179950323e-07 6.945644642767258 26.149362109896774 NVYK(ub)FELDTSER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NVYKFELDTSER 12 1 P04844;P04844-2 P04844 RPN2 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 1 42067200.0 1265800.0 3914400.0 36887000.0 True False 1052568.7844479405 3893312.350252438 44599901.15378214 1.0 3.698867387839582 42.37243381407538 20.00548308455352 -6.920993330389735 0.8173252732955101 0.17684929482003953 48.75365387146417 0.994452385397042 1.4076536903916386 0.09759104910589388 0.10261153936789504 1.219256768500892 3.6876706468121707 1.199517724415661e-07 6.920993330389735 48.57680457664413 up NVYPEEMIVALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NVYPEEMIVALR 12 0 Q5VT52-2;Q5VT52-3;Q5VT52;Q5VT52-5;Q5VT52-4 Q5VT52-2 RPRD2 Regulation of nuclear pre-mRNA domain-containing protein 2 0 2529750.0 882070.0 836990.0 810690.0 False True 1208195.1160454573 800009.0142442015 619221.7186846423 1.0 0.6621521669965945 0.512517978645218 20.204422029136396 -13.99999999999976 0.1104028402821131 2.629017168409187 0.239604764228494 0.9997410164959514 0.003281321340285693 12.010253250328098 0.10089274649769613 4.3578744759889165 0.24237893447810607 1.0000000000005522e-14 13.99999999999976 -2.389412404180693 NWMNSLGVNPR ddPTM_RPMI8226_Bortezomib_1h_R1 2 NWMNSLGVNPR 11 0 P13796 P13796 LCP1 Plastin-2 0 88250600.0 19207900.0 22624400.0 46418300.0 False True 25181742.90956819 19248927.709220495 41615379.59177458 1.0 0.7644001361759026 1.6526012413526063 24.585874804296697 -6.836152108114315 1.3000666308194995 0.874537746510863 1.6796732067723967 0.9176504412176132 0.10781073295185768 0.17333789044028927 0.5707406698129757 0.06506283616234998 0.14977931899096406 1.458303411896768e-07 6.836152108114315 0.8051354602615337 NWMNSLGVNPR ddPTM_RPMI8226_Bortezomib_2h_R1 2 NWMNSLGVNPR 11 0 P13796 P13796 LCP1 Plastin-2 0 69222800.0 20593600.0 9481900.0 39147300.0 False True 19939867.44036674 13268072.117455278 28893447.736173697 1.0 0.6654042288463301 1.4490290781813882 24.249152482986702 -6.7906739914260825 1.4935241858289345 0.8131562778096523 1.4575320434626318 0.8035286252194245 0.14230504886822393 0.23435150510183675 1.0326730180790151 0.07499268824535635 0.17549912789387212 1.619295125624414e-07 6.7906739914260825 0.6443757656529795 NWMNSLGVNPR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NWMNSLGVNPR 11 0 P13796 P13796 LCP1 Plastin-2 0 72329600.0 19207900.0 22641200.0 30480500.0 False True 26309579.7039799 21640836.91956392 23281633.66560246 1.0 0.8225459001266474 0.8849108928213173 24.64908486581959 -10.483471824517927 8.342192396828056 1.0000071809613644 0.8537283974086058 0.8800183766379193 0.0254604016523903 3.4005591304738644e-06 2.1059254714138408e-07 0.024653137505717668 0.008217309298954959 3.284945551707177e-11 10.483471824517927 -0.14627878355275858 NWMNSLGVNPR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NWMNSLGVNPR 11 0 P13796 P13796 LCP1 Plastin-2 0 43207800.0 20593600.0 12771000.0 9843200.0 False True 17124490.85116695 12702200.08815498 11901367.610185383 1.0 0.7417563651119816 0.6949910343976367 24.029557758420978 -13.999999999999998 0.24033019602227398 2.7120647035511807 0.6743785696371738 0.9995255082154658 0.002921631117503639 13.635050392377531 0.15515815856999782 11.205529224260001 0.022807015015850755 1.0000000000000041e-14 13.999999999999998 -2.037686133914007 NWMNSLGVNPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NWMNSLGVNPR 11 0 P13796 P13796 LCP1 Plastin-2 0 63918000.0 20063000.0 22568000.0 21287000.0 False True 25971949.000854902 21312070.961133614 17412984.423064783 1.0 0.8205803484533294 0.6704535120753399 24.630450945781288 -6.973179544709039 0.16545586960539746 1.1410439058306427 0.34598668363335255 0.9999977498043657 0.000201997050952921 0.0752838129534334 0.005136213036330976 0.0065990356991321355 0.0176658346644549 1.0637031743672027e-07 6.973179544709039 -0.7950572221972902 NWQDYGVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NWQDYGVR 8 0 Q8WU39 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 30106300.0 3204300.0 11961000.0 14941000.0 False True 4200868.330485342 10176465.423612824 13395048.644192157 1.0 2.422467124180752 3.188638060132815 22.002256136883243 -8.95298293918049 0.22164187637424138 2.999129167171325e-16 3.865862342669405 0.9994222669109436 0.02179590236277403 0.43615485860218656 0.07285959636367745 0.6921126561126332 0.36638854712167096 1.1143383083853896e-09 8.95298293918049 3.8658623426694048 NWQDYGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NWQDYGVR 8 0 Q8WU39 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 21423200.0 7513000.0 3248200.0 10662000.0 False True 7274503.927408283 4545223.199139232 7869302.346856206 1.0 0.6248155536783905 1.0817648083475342 22.79441743853138 -6.688524181060527 1.87168805028477 0.7644597206805932 1.0801573771268718 0.3635384119092977 0.1587242118285254 0.4198346681139472 2.850410113068187 0.06787085597026046 0.17706808206896163 2.04868797798736e-07 6.688524181060527 0.31569765644627856 NWQDYGVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NWQDYGVR 8 0 Q8WU39 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 90062100.0 6684500.0 77295000.0 6082600.0 False True 10140875.20240909 63501103.34140854 4880371.443901713 1.0 6.261895751002149 0.4812574207344865 23.273678832892795 -6.667137619138467 1.9475655051644296 4.36689074199858 0.5049180691461089 0.26640532409619466 2.236626446544001 0.46772671472798616 3.4174875808008975 0.9254653605436246 2.481836255187522 2.1520996698008905e-07 6.667137619138467 -3.861972672852471 NWQDYGVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NWQDYGVR 8 0 Q8WU39 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 26795300.0 3204300.0 10675000.0 12916000.0 False True 4389016.302951538 10203343.202495666 9865506.813369894 1.0 2.3247448854619415 2.2477717402725323 22.065466198406135 -10.187850569095804 5.3317994837370914 0.9999398734729831 2.2862583128673166 0.9973213346267097 0.03142415493633848 2.2463068139234365e-05 3.4215991836616514e-06 0.03042771301539551 0.010142102394592708 6.488576523798759e-11 10.187850569095804 1.2863184393943334 NWQDYGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NWQDYGVR 8 0 Q8WU39 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 10516700.0 7513000.0 1770800.0 1232900.0 False True 6247392.38233321 1761260.3489237223 1490693.6897144793 1.0 0.2819192778581238 0.23861054316517108 22.574822713965656 -13.661713013786304 0.4024783815268691 9.99999999999877 0.2361704395280021 0.9998350713930728 0.0044840981855551985 20.43556365622156 0.2089324033302269 159.07797837787 0.011010082654621238 2.179149300709592e-14 13.661713013786304 -9.763829560470768 NWQDYGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NWQDYGVR 8 0 Q8WU39 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 19449300.0 6684500.0 6215900.0 6548900.0 False True 8653217.021193981 5869979.700784764 5357067.3973885 1.0 0.6783580819026792 0.6190839065133403 23.044805154985244 -13.999999999363398 0.23784923234061306 3.106991525554987 0.5923354541159133 0.9995214591616738 0.003660944449526646 13.54844726046669 0.1543684779522564 13.54176183539257 0.029334172755403547 1.00000000146583e-14 13.999999999363398 -2.5146560714390738 NWQYQETIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NWQYQETIK 9 0 Q15008;Q15008-4;Q15008-3;Q15008-2 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 0 5707660.0 883760.0 2465300.0 2358600.0 False True 1158617.9183440139 2097486.8496641316 2114554.6972887777 1.0 1.8103352420632521 1.8250664553082887 20.14397345129372 -11.127067889947194 0.6670294352099401 1.2353056509014554e-14 1.8227224965791302 0.9999658635705556 0.0022524163044207843 3.3690705104694154 0.33703114689178304 5.078707085294554 0.0023712618987188554 7.463320808832181e-12 11.127067889947194 1.8227224965791178 NWQYQETIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NWQYQETIK 9 0 Q15008;Q15008-4;Q15008-3;Q15008-2 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 0 5973560.0 883760.0 2857200.0 2232600.0 False True 1210509.9547159905 2730959.456503102 1705305.8618403266 1.0 2.256040477704158 1.4087499695452113 20.207183512816613 -10.14255238164654 5.1732636272537516 0.9999694841066927 1.8323952236254877 0.5627202699541276 0.34590490148494857 0.00012174867363281834 2.0179401091715692e-05 0.33493321285828215 0.11164032690149078 7.201908814739022e-11 10.14255238164654 0.832425739518795 NWSAAGNAFCQAAQLHLQLQSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NWSAAGNAFCQAAQLHLQLQSK 22 0 P54920;M0R058 P54920 NAPA Alpha-soluble NSF attachment protein 0 120808000.0 25989000.0 40297000.0 54522000.0 False True 39427213.0504016 33105685.50810192 43745702.802158475 1.0 0.8396658791424446 1.1095306875034854 25.232688400006857 -6.745774811038448 1.665749121750973 0.9052447790438708 1.1098906468353764 0.6305038261626321 0.06736367924913225 0.30746160684610774 1.6771774895861398 0.031966742109501296 0.07794588899526517 1.795664467580009e-07 6.745774811038448 0.20464586779150562 NWSAAGNAFCQAAQLHLQLQSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NWSAAGNAFCQAAQLHLQLQSK 22 0 P54920;M0R058 P54920 NAPA Alpha-soluble NSF attachment protein 0 82677000.0 25989000.0 31608000.0 25080000.0 False True 33643272.8197786 29848987.014334988 20515697.34253137 1.0 0.8872200744033149 0.6098008791365377 25.003814722099307 -6.955808045004225 0.4909627189051865 1.0060184750669818 0.4792194723597941 0.9995817455407101 0.0033531170000210987 0.08123401539971972 0.026934021409324965 0.004002559631371822 0.0228807336203527 1.107113011734474e-07 6.955808045004225 -0.5267990027071877 NWTIHTWIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NWTIHTWIR 9 0 D6RJC7;D6RH20;G5EA06;Q92552;Q92552-2 D6RJC7 MRPS27 28S ribosomal protein S27, mitochondrial 0 3172060.0 838880.0 679280.0 1653900.0 False True 812250.2135796953 950520.0463984035 1220693.9740635406 1.0 1.170230589671789 1.5028546052130647 19.63156469234562 -6.96049784092427 0.42836094875937847 0.9865556666615954 1.699250643283179 0.9997882164250445 0.0030390149275051547 0.07952377739054975 0.020477849410118053 0.004330705992610533 0.027628754132673152 1.0952220002007376e-07 6.96049784092427 0.7126949766215837 NWTIHTWIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NWTIHTWIR 9 0 D6RJC7;D6RH20;G5EA06;Q92552;Q92552-2 D6RJC7 MRPS27 28S ribosomal protein S27, mitochondrial 0 5019400.0 1285500.0 1518200.0 2215700.0 False True 1760784.0893312714 1451120.903983972 1692397.293773899 1.0 0.8241333578468975 0.9611611690656832 20.747786583349505 -10.037411704740332 4.884967725774846 1.000001172762559 0.8926472634775776 0.4500556818374968 0.05594136968369733 1.2983724666012795e-06 2.558618853408587e-07 0.05416607335851647 0.018054999427974 9.174624432867939e-11 10.037411704740332 -0.10735390928498145 NWVK(ub)ELQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NWVKELQR 8 1 P51148;P51148-2;K7ENY4;K7ERI8;K7ERQ8;F8VVK3;P20339-2;P20339 P51148 RAB5C;RAB5A Ras-related protein Rab-5C;Ras-related protein Rab-5A 1 4241300.0 1530600.0 1570000.0 1140700.0 True False 1272761.717076962 1561542.098379398 1379215.0959991117 1.0 1.2268927305306228 1.0836396770061811 20.279530916474535 -10.356373016735636 4.931208001774056 0.9998959556732155 1.155266203768446 0.6103393530844281 0.058482814205233755 6.694096697761498e-05 8.737204499106183e-06 0.056663607647544995 0.018875247121329364 4.401766321670115e-11 10.356373016735636 0.15537024809523048 NYDIGAALDTIQYSK(ub)HPPPL ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYDIGAALDTIQYSKHPPPL 20 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 112700200.0 24953800.0 52488400.0 35258000.0 True False 32714673.452942938 44657335.31818075 31609840.378617667 1.0 1.3650552062644377 0.9662282102276071 24.96343453447819 -6.665951694556899 1.9518625981983564 1.2338220705019616 0.967870746950705 0.2611721553514621 0.1552141633046669 0.4704864921579755 3.4516862381662654 0.0641106710225889 0.17218829945436248 2.157984422786276e-07 6.665951694556899 -0.2659513235512566 NYDIGAALDTIQYSK(ub)HPPPL ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYDIGAALDTIQYSKHPPPL 20 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 557390500.0 240476200.0 115890000.0 201024300.0 True False 232842414.66101676 162165481.35836628 148370005.23026857 1.0 0.6964602286677649 0.6372121052183417 27.794778643150273 -13.999999999999998 0.2297046571262837 2.9135415174160215 0.6083240914749397 0.999509390963927 0.0035197283297354253 13.282028399519712 0.1517545880499814 11.589836893211174 0.030811508549623043 1.0000000000000041e-14 13.999999999999998 -2.305217425941082 NYDIGAALDTIQYSK(ub)HPPPL ddPTM_RPMI8226_Bortezomib_8h_R1 1 NYDIGAALDTIQYSKHPPPL 20 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 1970172200.0 213260000.0 927492200.0 829420000.0 True False 323531011.39438397 761973970.3803648 665484773.4523005 1.0 2.3551806273418388 2.0569427659627824 28.26932876448698 -10.07806022482739 4.873538781554167 0.999963159217093 2.206061696657089 0.9561495945872965 0.1217550971012937 5.1263270232956746e-05 9.697524016016767e-06 0.11789263027350382 0.03929628860978332 8.354871508635767e-11 10.07806022482739 1.206098537439996 NYDIGAALDTIQYSK(ub)HPPPL ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYDIGAALDTIQYSKHPPPL 20 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 191363100.0 24953800.0 55664200.0 110745100.0 True False 34179894.21108884 53204771.58710626 84589388.24692865 1.0 1.5566101889761044 2.474828848928551 25.02664459600108 -6.963628952821372 0.38085633612319036 0.9375313546904136 3.1264221105058345 0.9998820248296991 0.006604949402084215 0.0784294181643397 0.01652015450917045 0.011939395570101916 0.0775568931069558 1.0873542272088148e-07 6.963628952821372 2.1888907558154207 NYDIGAALDTIQYSK(ub)HPPPL ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYDIGAALDTIQYSKHPPPL 20 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 575913900.0 240476200.0 167237700.0 168200000.0 True False 199966615.20197484 166336757.31601578 203369842.33106893 1.0 0.8318226377338465 1.0170189765209392 27.57518391858455 -11.764435678725036 15.794367859798005 0.9313466256744487 0.9319787268862156 0.0 0.08542048904927815 0.0 0.0 0.0 0.02493159695785383 1.7201420843761177e-12 11.764435678725036 0.0006321012117669333 NYDIGAALDTIQYSK(ub)HPPPL ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYDIGAALDTIQYSKHPPPL 20 1 Q13501;Q13501-2 Q13501 SQSTM1 Sequestosome-1 1 1825490000.0 213260000.0 1040670000.0 571560000.0 True False 276069273.9830692 982755799.67755 467541944.7008459 1.0 3.5598159313369315 1.6935674802025211 28.040455086579428 -6.564776851138538 2.326487789330848 2.7588153808631297 1.6968867370323029 0.0 1.1163282337825573 0.7465125598442804 7.577519170733763 0.40679858721173145 1.254123212879357 2.724100643872051e-07 6.564776851138538 -1.0619286438308269 NYEDEDSLK(ub)TLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYEDEDSLKTLR 12 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 7692600.0 2743000.0 1900300.0 3049300.0 True False 3757161.2267877758 1816338.4625482422 2329118.1423048037 1.0 0.4834337290606876 0.6199143453569885 21.84121159536413 -10.326546165071447 8.620033647774633 1.0000007021003223 0.5516740372088784 0.9350120767882867 0.055717978284419295 7.517779767859479e-07 5.875354142995276e-08 0.053948784893835526 0.01798290016499187 4.7146975190700123e-11 10.326546165071447 -0.4483266648914439 NYEIK(ub)NEADR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYEIKNEADR 10 1 O15145;C9JZD1;F8VR50 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 1 2248870.0 0.0 758870.0 1490000.0 True False 0.0 1061890.748454771 1099724.3009581454 0.0 NYEIK(ub)NEADR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NYEIKNEADR 10 1 O15145;C9JZD1;F8VR50 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 1 17179020.0 957420.0 4156600.0 12065000.0 True False 1452476.136777697 3414822.2543359715 9680347.461722637 1.0 2.351035013843132 6.664720484288566 20.470083030623318 -6.950041973520511 0.5583819382971559 0.9430977983178137 8.278244104849406 0.9992045781832763 0.06813167982874317 0.0834688785627122 0.03589254586444012 0.07317682413098851 0.35845944506731053 1.1219100191483327e-07 6.950041973520511 7.335146306531593 NYEIK(ub)NEADR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYEIKNEADR 10 1 O15145;C9JZD1;F8VR50 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 1 2093690.0 0.0 1187200.0 906490.0 True False 0.0 1180804.3179592518 1096032.8678637971 0.0 NYEIK(ub)NEADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYEIKNEADR 10 1 O15145;C9JZD1;F8VR50 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 1 20404520.0 957420.0 3327100.0 16120000.0 True False 1239399.0635696827 3141943.960244044 13186325.405167688 1.0 2.5350543280182127 10.6392894691955 20.241209352715767 -6.938599829160419 0.6724648128189888 0.9064535820540806 12.737560829709723 0.9979746692044056 0.19031519339620986 0.08841132820306404 0.05756267611519067 0.18334791715784587 0.7019280135145801 1.1518612566473282e-07 6.938599829160419 11.831107247655643 NYFAK(ub)VDCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYFAKVDCK 9 1 F5H0F9;Q9UJX4-3;Q9UJX4;F5H0N1 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 7067900.0 1324600.0 2240900.0 3502400.0 True False 1736563.4274446468 1906566.4549597867 3140005.2453931146 1.0 1.0978962385297377 1.8081719307043294 20.727803674998803 -6.931960541880384 0.7305184163984524 0.9899461548069519 1.9615462098474856 0.9969097924550502 0.020019276255352967 0.09163232939448128 0.07278567347082038 0.01845609507931281 0.0635888920728345 1.1696056515071029e-07 6.931960541880384 0.9716000550405337 NYFAK(ub)VDCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYFAKVDCK 9 1 F5H0F9;Q9UJX4-3;Q9UJX4;F5H0N1 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 1080700.0 0.0 1080700.0 0.0 True False 0.0 1512229.1457760483 0.0 0.0 NYFAK(ub)VDCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYFAKVDCK 9 1 F5H0F9;Q9UJX4-3;Q9UJX4;F5H0N1 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 5227800.0 1324600.0 0.0 3903200.0 True False 1814340.415969043 0.0 2981344.548927333 1.0 0.0 1.6432112313030247 20.791013736521695 -6.741992119419877 1.6795112061818405 0.40638179206616487 1.6445813970607752 0.6138241179970437 0.42014217120015696 0.3142145680205756 1.7410645545541508 0.19784387772318449 0.4844131597929971 1.8113729609631678e-07 6.741992119419877 1.2381996049946102 NYFAK(ub)VDCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYFAKVDCK 9 1 F5H0F9;Q9UJX4-3;Q9UJX4;F5H0N1 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 5175700.0 0.0 0.0 5175700.0 True False 0.0 0.0 6257914.940267037 0.0 NYFAK(ub)VDCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYFAKVDCK 9 1 F5H0F9;Q9UJX4-3;Q9UJX4;F5H0N1 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 27583700.0 3362200.0 5348500.0 18873000.0 True False 4352434.178870282 5050851.273290639 15438307.653333109 1.0 1.1604658601871465 3.547051378348535 22.053391049731175 -6.920530796751859 0.8207958645094764 0.9483421586578058 3.936628256707199 0.9943267817288989 0.08772708999348378 0.09786036690272228 0.10400827912552861 0.07579899166850373 0.22821360793451365 1.2007959189850693e-07 6.920530796751859 2.988286098049393 up NYFHLWTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYFHLWTR 8 0 A6NHR9-2;A6NHR9 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 0 20423700.0 5213200.0 6849200.0 8361300.0 False True 6834555.684700618 5827326.057972491 7496152.883253042 1.0 0.8526269046307071 1.096801786257069 22.704416120423296 -6.743296234195399 1.6747105688931467 0.9126503239221021 1.0970482601834706 0.6196301441382195 0.06191719302116102 0.31187594819969133 1.7187088755147957 0.02923445008163173 0.07147850768812644 1.8059418648246475e-07 6.743296234195399 0.18439793626136847 NYFHLWTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYFHLWTR 8 0 A6NHR9-2;A6NHR9 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 0 12875300.0 4399200.0 1093400.0 7382700.0 False True 4259549.804000332 1530000.3220056726 5448949.393747442 1.0 0.35919296461066885 1.279231290741123 22.02226952797767 -6.719418644408516 1.7614823537159279 0.6098999109059867 1.2777438943885626 0.509756544768222 0.26967293641054924 0.35643912402004785 2.1611227846200256 0.1215760591666014 0.305401597917553 1.908013115123666e-07 6.719418644408516 0.6678439834825759 NYFHLWTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYFHLWTR 8 0 A6NHR9-2;A6NHR9 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 0 13978500.0 5213200.0 4355600.0 4409700.0 False True 7140660.921432749 4163155.1899569225 3368219.680622269 1.0 0.5830209886400263 0.4716957880624931 22.767626181946188 -13.999999999999998 0.18535581606830664 3.2005749087257365 0.38798759862528603 0.9994926463340289 0.005121923954530877 12.27875105949507 0.13651693628623374 9.74480446720858 0.07948517480565769 1.0000000000000041e-14 13.999999999999998 -2.8125873101004504 NYFHLWTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYFHLWTR 8 0 A6NHR9-2;A6NHR9 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 0 9313900.0 4399200.0 2879700.0 2035000.0 False True 3658129.717604184 2864186.4845243054 2460509.0912231016 1.0 0.7829647130173789 0.6726139533495168 21.802674803411946 -13.999999999949303 0.08698100520726017 2.1268034270317506 0.381767793644764 0.9998563472102735 0.001630017291903272 12.191256514495452 0.0849377969858811 2.567664659486449 0.262071155615204 1.0000000001167347e-14 13.999999999949303 -1.7450356333869865 NYFK(ub)DLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYFKDLPK 8 1 P48449;P48449-3;C9J315 P48449 LSS Lanosterol synthase 1 11803700.0 4469000.0 7334700.0 0.0 True False 5785208.597159972 6926517.497280512 0.0 1.0 1.19728050958799 0.0 22.463937548823342 -6.916802237426187 1.2652616212708072 1.1036607825696196 7.838597937330744e-22 0.9574249313917363 0.10814733192659792 0.12411958829821515 0.3978463342110862 0.07022330664801686 0.1375670588176033 1.2111495232888092e-07 6.916802237426187 -1.1036607825696196 down NYGFVHIEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYGFVHIEDK 10 0 Q9BQ04;E9PLB0;E9PM61;U3KQD5;Q9BWF3;E9PB51;D6R9K7;J3QRR5;Q9BWF3-3;Q9BWF3-4;Q9BWF3-2 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 0 5254400.0 1338700.0 2086300.0 1829400.0 False True 1755048.6639892396 1775032.172333707 1640111.2368439247 1.0 1.0113862987132476 0.9345104044670413 20.74307960345662 -6.869233997285557 1.1382201037391797 1.0064100582855298 0.9300747702997283 0.9639085017266528 0.006435738017148089 0.1375872669600781 0.3336392592528368 0.004390327089323005 0.010380083061698273 1.3513442645277371e-07 6.869233997285557 -0.07633528798580147 NYGFVHIEDK(ub)TAAEDAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYGFVHIEDKTAAEDAIR 18 1 Q9BQ04;E9PLB0;E9PM61;U3KQD5;Q9BWF3;E9PB51;D6R9K7;J3QRR5;Q9BWF3-3;Q9BWF3-4;Q9BWF3-2 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 1 8470700.0 1268900.0 2756000.0 4445800.0 True False 1663540.1880450784 2344815.542803862 3985791.2631249237 1.0 1.4095334514036535 2.395969326000387 20.66582528880194 -6.956254372928475 0.48535504317406325 0.9774756383963047 2.8695282595707163 0.9996050555795124 0.011643701038931906 0.0810673399567022 0.026289572899207626 0.01406303602246352 0.08136134243072031 1.1059758072649409e-07 6.956254372928475 1.8920526211744115 up NYGFVHIEDK(ub)TAAEDAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYGFVHIEDKTAAEDAIR 18 1 Q9BQ04;E9PLB0;E9PM61;U3KQD5;Q9BWF3;E9PB51;D6R9K7;J3QRR5;Q9BWF3-3;Q9BWF3-4;Q9BWF3-2 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 1 12228500.0 2707000.0 3155800.0 6365700.0 True False 2621067.766736888 4415927.397279594 4698332.203093461 1.0 1.6847818485735782 1.7925260318403267 21.321723223818957 -11.271645253867884 0.3280622559549717 8.690415748813631e-11 1.815360226309565 0.9993902377860991 0.008666678897256308 3.388622595129674 0.16884637750245643 2.4969565054515557 0.03469792840818046 5.350011876731541e-12 11.271645253867884 1.8153602262226607 NYGSYSTQASAAAATAELLK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYGSYSTQASAAAATAELLKK 21 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 493190000.0 174890000.0 195510000.0 122790000.0 True False 229282483.63716945 166340670.092011 110084868.68485051 1.0 0.725483549607909 0.4801276876390414 27.772550901479168 -6.972454424746897 0.1906526136315135 1.1648772285286852 0.0340266974290136 0.9999957341231562 0.00043854605035325444 0.07551405116447511 0.006086883271800719 0.008614092167552491 0.02669831598265376 1.0654806702996899e-07 6.972454424746897 -1.1308505310996717 down NYGSYSTQASAAAATAELLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYGSYSTQASAAAATAELLKK 21 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 703060000.0 259270000.0 282720000.0 161070000.0 True False 251039615.76722258 395611570.3653231 118880935.00357608 1.0 1.575892988667396 0.4735544811931551 27.903339808378817 -6.764727236225782 1.594508113852974 1.332536067223032 0.46853453042073906 0.7100282913428736 0.24241682672977177 0.2750463318045025 1.3791733822612147 0.11989346196311075 0.2868137537875087 1.718987678687602e-07 6.764727236225782 -0.8640015368022929 down NYGSYSTQASAAAATAELLK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 NYGSYSTQASAAAATAELLKK 21 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 1278340000.0 469060000.0 346360000.0 462920000.0 True False 711598312.8793479 284549351.8769682 371423659.0949567 1.0 0.3998735617087021 0.5219569135739813 29.406487849238143 -10.000153467073194 6.132913706455499 1.0000003978180965 0.46091523764196485 0.9629602204993318 0.04984031969321758 2.7105929354280865e-07 4.420401458869035e-08 0.04825771798854462 0.01608589401177297 9.996466914331756e-11 10.000153467073194 -0.5390851601761316 NYGSYSTQASAAAATAELLK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYGSYSTQASAAAATAELLKK 21 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 519210000.0 174890000.0 205920000.0 138400000.0 True False 239551559.22454044 196821773.51362106 105712770.43747255 1.0 0.8216259336852524 0.44129443690401576 27.83576096300206 -6.958774223321172 0.4523850034339977 1.0119702960105226 0.235812579249202 0.9997219788536387 0.003885110369690207 0.08014203492774678 0.022772082157774678 0.005101915920345809 0.0314488678929954 1.0995773281518213e-07 6.958774223321172 -0.7761577167613206 down NYGSYSTQASAAAATAELLK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYGSYSTQASAAAATAELLKK 21 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 647840000.0 259270000.0 278700000.0 109870000.0 True False 215594492.60848257 277198587.7823811 132843309.01851694 1.0 1.2857405791240268 0.6161720896078688 27.683745083813093 -6.790745426992685 1.4933057447626195 1.1595473586089289 0.6089000166319966 0.8037345292332904 0.12153158184167624 0.23424820223132947 1.0319245187196666 0.06405534072593153 0.14989129747648486 1.619028795388528e-07 6.790745426992685 -0.5506473419769323 NYGSYSTQASAAAATAELLK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYGSYSTQASAAAATAELLKK 21 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 1222360000.0 469060000.0 461780000.0 291520000.0 True False 607207416.5549021 436081537.0627563 238466351.24779686 1.0 0.7181755775266078 0.3927263481081598 29.177614171330593 -6.969239291819268 0.27575385118531964 1.0754641605681565 0.02557780138381004 0.9999758243441729 0.0012200181643217197 0.07655035469166369 0.009910532224823755 0.006162351172610199 0.030035668503941612 1.0733978181517374e-07 6.969239291819268 -1.0498863591843466 down NYGSYSTQASAAAATAELLK(ub)K(ub)QEELNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYGSYSTQASAAAATAELLKKQEELNR 27 2 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 2 23486600.0 7477900.0 9809100.0 6199600.0 True False 9803599.316086601 8345620.515572331 5558124.862762444 1.0 0.8512812739988371 0.5669473714253281 23.224880090196844 -6.960916517062303 0.4223205806680721 1.0122584978679785 0.3952034635043344 0.999802689283555 0.0025236215372388656 0.07937536558745148 0.019933711924093746 0.0036838638840348426 0.023653710396596035 1.0941666739624858e-07 6.960916517062303 -0.6170550343636441 NYGSYSTQASAAAATAELLK(ub)K(ub)QEELNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYGSYSTQASAAAATAELLKKQEELNR 27 2 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 2 48843000.0 17339000.0 18699000.0 12805000.0 True False 16788582.935888752 26165608.2139968 9450986.358234258 1.0 1.5585358403336649 0.5629412794590899 24.00097712690796 -6.754473768907302 1.6332884869101634 1.326647392106978 0.5602661461780861 0.6680084450348385 0.23477148220502547 0.2922978116871695 1.5354128054645235 0.1134877954141126 0.27423614429223236 1.7600549667195914e-07 6.754473768907302 -0.7663812459288918 NYGSYSTQASAAAATAELLK(ub)K(ub)QEELNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NYGSYSTQASAAAATAELLKKQEELNR 27 2 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 2 202607100.0 52754400.0 85637700.0 64215000.0 True False 80032281.66324621 70354983.34459594 51522877.10356567 1.0 0.8790825637163554 0.643776186718751 26.25407870423027 -6.96057658612219 0.42723065545817845 1.009625953622411 0.5042503109242228 0.9997909867693299 0.00213831135904216 0.07949580301492616 0.020375064074183668 0.0030605660163121854 0.01955060152161014 1.0950234352672366e-07 6.96057658612219 -0.5053756426981882 NYGSYSTQASAAAATAELLK(ub)K(ub)QEELNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYGSYSTQASAAAATAELLKKQEELNR 27 2 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 2 27297100.0 7477900.0 9978800.0 9840400.0 True False 10242681.71264902 9537903.6205212 7516300.189399591 1.0 0.931192034283613 0.733821512789709 23.288090151719736 -6.952454259213497 0.5312156809267631 1.0030859148085773 0.6529491056354932 0.999380082781289 0.0028088237723163656 0.08251493298663566 0.03199750842880182 0.003128072421296874 0.016324097240252897 1.1156956525198176e-07 6.952454259213497 -0.3501368091730841 NYGSYSTQASAAAATAELLK(ub)K(ub)QEELNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYGSYSTQASAAAATAELLKKQEELNR 27 2 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 2 44851400.0 17339000.0 18868000.0 8644400.0 True False 14418146.747940306 18766354.33899521 10451904.072810307 1.0 1.3015788136347042 0.7249131428283879 23.781382402342235 -6.764571115292109 1.5950163377375572 1.1741719593442221 0.7222975611563734 0.7094527184282005 0.12694324288029582 0.27529732659543654 1.381268966900582 0.06276303038895488 0.15017162853821336 1.7196057344432773e-07 6.764571115292109 -0.4518743981878487 NYGSYSTQASAAAATAELLK(ub)K(ub)QEELNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYGSYSTQASAAAATAELLKKQEELNR 27 2 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 2 160154400.0 52754400.0 79797000.0 27603000.0 True False 68291610.74468921 75356226.80279954 22579537.230697475 1.0 1.1034477878186482 0.33063412891390037 26.02520502632272 -6.8731483531588635 1.1172538327718329 1.0597882145135804 0.2825709727781403 0.9677281513855646 0.06153485738418096 0.13387465895865197 0.31041029456657154 0.04265561288007715 0.1015827954217442 1.3392191376865098e-07 6.8731483531588635 -0.7772172417354402 down NYGTK(ub)LGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYGTKLGVK 9 1 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 1 11456300.0 4352100.0 3775200.0 3329000.0 True False 5705645.245796355 3211954.875614345 2984547.0140228663 1.0 0.5629433196851414 0.5230866773958189 22.44395861802423 -13.999999999999998 0.3388851907023969 6.02078270365216 0.5167417467840478 0.9997329737064861 0.0035302660507642494 19.60199168712299 0.1866655923402288 70.4639292816488 0.0123634331819414 1.0000000000000041e-14 13.999999999999998 -5.504040956868113 NYGTK(ub)LGVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYGTKLGVK 9 1 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 1 16262100.0 4428000.0 4897200.0 6936900.0 True False 4287435.563764662 6852677.49856062 5119917.787460776 1.0 1.5983161488130915 1.1941678682548265 22.031683558385545 -10.169477862145168 4.650360440457319 0.9999457654414806 1.39624200853687 0.5617257048363968 0.16499284464504024 9.309930690078485e-05 1.6626942993479787e-05 0.15977551852725397 0.053251211627600714 6.768962963515189e-11 10.169477862145168 0.39629624309538947 NYGTK(ub)LGVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NYGTKLGVK 9 1 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 1 24408800.0 8365200.0 7543100.0 8500500.0 True False 12690619.97803763 6196974.870490696 6820372.4490984995 1.0 0.48831143641643776 0.5374341411926152 23.59725921545453 -10.388110284137069 9.118342503178129 1.0000012829873148 0.5128727894956634 0.9924309502050456 0.0200542602478355 5.230588951498037e-07 3.507983376361892e-08 0.019417505044988157 0.006472484663364697 4.0915674584138065e-11 10.388110284137069 -0.48712849349165144 NYGTK(ub)LGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYGTKLGVK 9 1 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 1 12795100.0 4352100.0 3170400.0 5272600.0 True False 5961188.981080233 3030321.2448892025 4027320.472605612 1.0 0.5083417510343843 0.6755901356906516 22.50716867954712 -10.207203701475384 6.960218340675953 1.0000012378302041 0.5919659433625181 0.8880944879674003 0.06827886711876381 1.3115214946267676e-06 1.49322169817366e-07 0.06611092975209269 0.022036909604073455 6.205778901147206e-11 10.207203701475384 -0.40803529446768605 NYGTK(ub)LGVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYGTKLGVK 9 1 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 1 15514800.0 4428000.0 6609200.0 4477600.0 True False 3682078.1936605186 6573594.927776518 5413845.457916734 1.0 1.78529476617155 1.4703233264404383 21.81208883381982 -10.06557490066986 4.635279812557355 0.9999719915116709 1.627809046298325 0.8412008479011268 0.12858655188552257 89202273.09597668 0.018621548817000688 27872.466120276276 0.04401859690163332 8.598547591066021e-11 10.06557490066986 0.6278370547866541 NYGTK(ub)LGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYGTKLGVK 9 1 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 1 22377900.0 8365200.0 7430600.0 6582100.0 True False 10828916.302743945 7017080.577977637 5384225.338049264 1.0 0.6479947191206543 0.497208140456765 23.36838553754698 -13.999999999999998 0.11572166377437876 2.6844824181125158 0.24206089444932696 0.9997141664912773 0.0035617437970300145 11.982195186915751 0.10411654357074025 4.670298988306124 0.22641728135673467 1.0000000000000041e-14 13.999999999999998 -2.4424215236631888 NYHCNNSEK(ub)TLNQSSSPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYHCNNSEKTLNQSSSPK 18 1 Q14586 Q14586 ZNF267 Zinc finger protein 267 1 7540900.0 1106300.0 2246000.0 4188600.0 True False 1450370.0134244396 1910905.5548394297 3755203.851888306 1.0 1.3175296904599048 2.5891350601092267 20.46798957193265 -6.944847666270688 0.6128058281101666 0.9859868766295374 2.987218884524516 0.9987323876833969 0.024446485657759733 0.08562300847874404 0.04504984308386661 0.024783724110523406 0.10733196573503842 1.1354090034562015e-07 6.944847666270688 2.0012320078949783 up NYHCNNSEK(ub)TLNQSSSPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYHCNNSEKTLNQSSSPK 18 1 Q14586 Q14586 ZNF267 Zinc finger protein 267 1 6647900.0 1106300.0 2044500.0 3497100.0 True False 1515329.0066333625 1954167.2297426104 2671157.0050352938 1.0 1.2895993023219583 1.762757126236142 20.531199633455543 -6.96379834816768 0.3781141679707724 0.96680155887873 2.1022368330365304 0.9998861835939906 0.0033540102003208187 0.07837119546758461 0.016312865641465113 0.006170177544849862 0.04001792991304216 1.086930190440472e-07 6.96379834816768 1.1354352741578004 NYILDQTNVYGSAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYILDQTNVYGSAQR 15 0 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;Q9BUJ2-3 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 0 8773200.0 2127700.0 3458600.0 3186900.0 False True 2789435.3046761127 2942590.36151721 2857150.1589034176 1.0 1.054905398445468 1.0242754704200487 21.41154166069751 -10.388596384665904 3.982104641494505 0.9998544818741335 1.0395904344342703 0.6901673485763749 0.012504615758402787 1.6214172317138597e-05 2.4895026618802136e-06 0.01215203135052255 0.004035847381235585 4.08699037875891e-11 10.388596384665904 0.039735952560136845 NYILDQTNVYGSAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYILDQTNVYGSAQR 15 0 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;Q9BUJ2-3 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 0 5628500.0 2111300.0 0.0 3517200.0 False True 2044277.9371671928 0.0 2595939.8062617374 1.0 0.0 1.2698565880229555 20.96315992573342 -6.696751118331536 1.84255597417633 0.37706359276604273 1.265842760583589 0.40210278432243207 0.42237006809787453 0.402333507242441 2.6532490708025707 0.1830393494322637 0.4726083767880857 2.0102444958441314e-07 6.696751118331536 0.8887791678175462 NYILDQTNVYGSAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYILDQTNVYGSAQR 15 0 M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;Q9BUJ2-3 M0R3F1 HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U-like protein 1 0 7910700.0 2127700.0 2436400.0 3346600.0 False True 2914368.188930497 2328751.791902615 2556202.005390502 1.0 0.7990588837566235 0.877103316972646 21.4747517222204 -10.335630109113628 4.804829841350213 1.0001040181280987 0.8380811003779145 0.8516140242861543 0.03186150644105878 3.5525291286633556e-05 4.91212779989749e-06 0.030869548334627947 0.010283256985885404 4.6171064852421106e-11 10.335630109113628 -0.16202291775018418 NYIMTQK(ub)MDLDEDTAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NYIMTQKMDLDEDTAEK 17 1 P56937-3;P56937-2;P56937 P56937-3 HSD17B7 3-keto-steroid reductase 1 15401100.0 2076800.0 4316700.0 9007600.0 True False 3150657.434417409 3546351.158468958 7227243.911828673 1.0 1.1255908432725938 2.2938843915175027 21.58722147044766 -6.927402580876868 0.7678077544012304 0.9804186734800735 2.5186039573364956 0.9960028652236153 0.036833749218258785 0.09400866657309395 0.0844512046960015 0.033052971654934565 0.10725936616472095 1.1819454118657665e-07 6.927402580876868 1.538185283856422 up NYIQGINLVQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYIQGINLVQAK 12 0 B4DLN1;P52815 B4DLN1 MRPL12 39S ribosomal protein L12, mitochondrial 0 28865300.0 5610300.0 12199000.0 11056000.0 False True 7355157.630222478 10378956.751329565 9912031.176640665 1.0 1.4111127555828635 1.347630013517582 22.810324829893794 -10.134518170635431 4.82264571998389 0.9999745813595817 1.379371384552507 0.979430806638305 0.025916720929979885 7.083486749603033e-06 1.2712092769693945e-06 0.025095436735086175 0.008364585711390368 7.336380187765525e-11 10.134518170635431 0.37939680319292535 NYIQGINLVQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYIQGINLVQAK 12 0 B4DLN1;P52815 B4DLN1 MRPL12 39S ribosomal protein L12, mitochondrial 0 22398200.0 7756200.0 3337000.0 11305000.0 False True 7509983.676529236 4669481.5022251075 8343881.357269669 1.0 0.6217698604084215 1.1110385477063809 22.840378341269325 -6.700305615607959 1.8298987783093912 0.7652001275429996 1.1095846943699492 0.4189408929683185 0.15964736965340498 0.3949048670224612 2.571081732818812 0.06959750146527967 0.17891098713842052 1.9938587309329843e-07 6.700305615607959 0.3443845668269496 NYIQGINLVQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYIQGINLVQAK 12 0 B4DLN1;P52815 B4DLN1 MRPL12 39S ribosomal protein L12, mitochondrial 0 26283300.0 5610300.0 10422000.0 10251000.0 False True 7684579.522656736 9961521.579054775 7829924.925972032 1.0 1.2963001488480723 1.0189139045131577 22.873534891416686 -10.553539348454159 3.384474091273627 0.9951426233553108 1.1576070265194187 0.3009179980008164 0.11324246020239336 41183117.76058478 7789.178212946153 1559381.6612807226 0.038765896914511336 2.7955074342879466e-11 10.553539348454159 0.16246440316410793 NYIQGINLVQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYIQGINLVQAK 12 0 B4DLN1;P52815 B4DLN1 MRPL12 39S ribosomal protein L12, mitochondrial 0 13395300.0 7756200.0 2691500.0 2947600.0 False True 6449623.957919988 2677000.355279082 3563929.5318374527 1.0 0.4150630134012368 0.5525794302257002 22.6207836167036 -10.080196321690368 7.6194260519577295 1.0000000506318805 0.4838212218138171 0.9494587284322258 0.05614084207930322 4.8293673651652834e-08 5.846893641907741e-09 0.0543581422737528 0.018119378867933494 8.313878594258154e-11 10.080196321690368 -0.5161788288180633 NYIQGINLVQAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYIQGINLVQAK 12 0 B4DLN1;P52815 B4DLN1 MRPL12 39S ribosomal protein L12, mitochondrial 0 13865500.0 0.0 6196200.0 7669300.0 False True 0.0 5851376.023102455 6273566.093663311 0.0 NYK(ub)HCFPEIFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYKHCFPEIFGK 12 1 P43355 P43355 MAGEA1 Melanoma-associated antigen 1 1 46136100.0 2830800.0 6460300.0 36845000.0 True False 3664526.4034102634 6100778.625939893 30139588.061625473 1.0 1.6648204854691226 8.224688470951422 21.80519532850159 -6.926415278193208 0.775654532052283 0.8858780333828044 9.456173040080571 0.995785566654538 0.2116587253530661 0.0945422555788373 0.08711599701811401 0.1888678151615223 0.6056744911948742 1.1846354421555225e-07 6.926415278193208 8.570295006697767 up NYK(ub)TAPFDSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYKTAPFDSR 10 1 P14854;A0A494C160;K7EQD3 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 1 8127700.0 905800.0 1431900.0 5790000.0 True False 1187512.5717796767 1218266.1015024837 5190906.341601796 1.0 1.0258974350702814 4.371243273511115 20.179511356155707 -6.908596593572311 0.9052381054506993 0.8917684605836232 4.790843203648068 0.9903811321840881 0.1552687980731366 0.10535335194359378 0.14385505845023278 0.12624512328542362 0.3451967106682589 1.2342507688546018e-07 6.908596593572311 3.899074743064445 up NYK(ub)TAPFDSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYKTAPFDSR 10 1 P14854;A0A494C160;K7EQD3 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 1 44860700.0 8170600.0 10721800.0 25968300.0 True False 7911228.7753603235 15003070.653448364 19166423.197698925 1.0 1.8964273540130352 2.4226860001057133 22.915470361422948 -8.958750632381323 0.16619556493621043 1.0288630559281739e-19 3.1908172880025485 0.9997764773992642 0.008780915424756766 0.4444743862412061 0.053700598101324035 0.5782392442863652 0.350885635941223 1.0996370589755737e-09 8.958750632381323 3.1908172880025485 NYK(ub)TAPFDSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NYKTAPFDSR 10 1 P14854;A0A494C160;K7EQD3 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 1 57406100.0 7794600.0 15270500.0 34341000.0 True False 11824978.061589917 12545359.96603892 27553486.29780503 1.0 1.0609203586422675 2.3301088724472736 23.49533417120413 -6.916901532443011 0.8473858494285028 0.9687486234227325 2.5208713046099653 0.9932761181864372 0.05027907687966117 0.10002941834330883 0.11531347764335079 0.042624262722900534 0.12413184542112544 1.2108726434978232e-07 6.916901532443011 1.5521226811872328 up NYK(ub)TAPFDSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYKTAPFDSR 10 1 P14854;A0A494C160;K7EQD3 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 1 10452100.0 905800.0 4769100.0 4777200.0 True False 1240698.7383245942 4558385.392695271 3648923.749522355 1.0 3.674046931691726 2.941023180574651 20.2427214176786 -10.129326771906413 5.639574646170161 0.9999716259676111 3.3075350561334504 0.9296415493117801 0.29925569326387774 0.00010676282024789399 1.64822353992933e-05 0.28975659658749275 0.09658435968892844 7.424602856196334e-11 10.129326771906413 2.3075634301658394 NYK(ub)TAPFDSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYKTAPFDSR 10 1 P14854;A0A494C160;K7EQD3 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 1 36258700.0 8170600.0 18308300.0 9779800.0 True False 6794215.918952712 18209669.553986993 11824710.963313846 1.0 2.680172336470859 1.740408474556775 22.695875636857224 -10.077212054575712 4.640832916205742 0.9999376204613056 2.2102904055477706 0.688615812411518 0.3836569901796005 133227937.80271967 9.96958981139411 89906.4741656147 0.13133599239918753 8.371204384232436e-11 10.077212054575712 1.210352785086465 NYK(ub)TAPFDSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYKTAPFDSR 10 1 P14854;A0A494C160;K7EQD3 P14854 COX6B1 Cytochrome c oxidase subunit 6B1 1 40499400.0 7794600.0 11488200.0 21216600.0 True False 10090263.354536394 10848871.571060594 17355396.500699762 1.0 1.075182201878125 1.720014224692867 23.26646049329658 -6.92882292921177 0.7563845364334314 0.9897544941498274 1.8485155054890936 0.9963020312985872 0.019651550421918993 0.09325312455168498 0.08070592525212732 0.017779898562745512 0.05872808207136138 1.1780862055782974e-07 6.92882292921177 0.8587610113392662 NYLEPGK(ub)ECVQPATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYLEPGKECVQPATK 15 1 P16615;P16615-4;H7C5W9 P16615 ATP2A2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 1 11200100.0 2499100.0 2544200.0 6156800.0 True False 3276344.301318825 2164615.277213927 5519753.396195852 1.0 0.6606800379137826 1.684729347270978 21.643655542818607 -6.817417510203444 1.3832054518359234 0.8166211900929442 1.7058359105661243 0.8782964520950765 0.14858654288914913 0.19686023276102835 0.7408034232938902 0.08443356355287866 0.1947341858204811 1.5225883054983548e-07 6.817417510203444 0.8892147204731801 NYLEPGK(ub)ECVQPATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYLEPGKECVQPATK 15 1 P16615;P16615-4;H7C5W9 P16615 ATP2A2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 1 11330000.0 2499100.0 1860000.0 6970900.0 True False 3423084.8056381047 1777819.0498025238 5324516.990192032 1.0 0.5193616725108032 1.5554732916409524 21.7068656043415 -6.780573469129361 1.5337278710584286 0.7280550276233101 1.5638159235876803 0.7693902861108917 0.2033044977308117 0.24968122232541373 1.1601421754031778 0.10440200041204116 0.24621760871095338 1.657396933079151e-07 6.780573469129361 0.8357608959643702 NYLHYSLYDQAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYLHYSLYDQAEK 13 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 21810700.0 5122200.0 7312300.0 9376200.0 False True 6715253.803455368 6221333.343122148 8406040.766861282 1.0 0.9264479832349641 1.2517830320182257 22.67901049676048 -6.847305045430108 1.248034052945943 0.9608228256568744 1.264127443352532 0.9362909102204775 0.0351609509322274 0.1604457757084193 0.48226888880685537 0.022060000510731464 0.05096773609480689 1.4213301040287275e-07 6.847305045430108 0.30330461769565764 NYLHYSLYDQAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYLHYSLYDQAEK 13 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 14907400.0 5122200.0 4420700.0 5364500.0 False True 7016015.76225022 4225378.856700007 4097515.585345526 1.0 0.6022476288372558 0.5840231442170172 22.74222055828337 NYLHYSLYDQAEK(ub)LVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYLHYSLYDQAEKLVSK 17 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 7876400.0 3740100.0 0.0 4136300.0 True False 3621372.5727272322 0.0 3052878.943659845 1.0 0.0 0.8430170832604339 21.788105180597007 -9.732910028406682 11.071346979313274 1.0000039513126984 0.42150854165090396 0.38569496099081824 0.34416028308046503 0.0 0.0 0.3332317611957515 0.11107725373191714 1.849651766558028e-10 9.732910028406682 -0.5784954096617945 NYLHYSLYDQAEK(ub)LVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYLHYSLYDQAEKLVSK 17 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 6855800.0 3740100.0 0.0 3115700.0 True False 3110058.8645234155 0.0 3767178.464630869 1.0 0.0 1.2112884767562593 21.568510456031284 -10.756686174832529 6.239754390290817 1.0119583065283462 0.6056442383781296 0.12382561614372045 0.4945064498943195 0.08232885158690266 0.0032103388868428427 0.4791800424631489 0.1596012704194043 1.7511116008207216e-11 10.756686174832529 -0.40631406815021653 NYMSEHLLK(ub)AGANITPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYMSEHLLKAGANITPR 17 1 P53350 P53350 PLK1 Serine/threonine-protein kinase PLK1 1 9296300.0 2381400.0 3812900.0 3102000.0 True False 1980239.613907666 3792359.1508986093 3750613.8579725153 1.0 1.9151011444594999 1.8940202143372524 20.917243579871894 -10.631098362399047 6.358946451811254 0.9959204533430651 1.9045606793983672 0.9995928178674881 0.008606253683795672 0.0004982138662653693 2.890286098118221e-05 0.008340700330218364 0.0027776564325480823 2.3383075805560246e-11 10.631098362399047 0.908640226055302 NYMSEHLLK(ub)AGANITPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYMSEHLLKAGANITPR 17 1 P53350 P53350 PLK1 Serine/threonine-protein kinase PLK1 1 20028200.0 4382100.0 6110500.0 9535600.0 True False 5672714.834104889 5770445.303438809 7800218.643518411 1.0 1.0172281653832402 1.3750415579896191 22.43560791125241 -6.916931294946049 0.8471796104689442 0.9911986155954485 1.4288562722676987 0.9932850540531255 0.014166504780803899 0.10001113801062826 0.11522079419175964 0.012011549898524035 0.03498903574093546 1.2107896643963483e-07 6.916931294946049 0.4376576566722502 NYNK(ub)AVEEEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYNKAVEEEDK 11 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 6239000.0 1119800.0 1360300.0 3758900.0 True False 1468068.6441586274 1157348.5424078694 3369965.085914857 1.0 0.7883477022773439 2.295509204779887 20.48548799681859 -6.8713532606314605 1.1269904495794765 0.8792739023340109 2.3860459911226926 0.9660113070347119 0.12282500460403689 0.13555989637968402 0.32098079397411716 0.08451355482870179 0.2005612469524399 1.3447660593169962e-07 6.8713532606314605 1.5067720887886815 up NYNK(ub)AVEEEDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NYNKAVEEEDK 11 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 26314720.0 911520.0 6654200.0 18749000.0 True False 1382842.481038213 5466706.020498096 15043251.932021378 1.0 3.9532384168540964 10.878500001480413 20.399205398431814 -6.956819027582424 0.478167878884441 0.8308739408829013 14.28870070517535 0.9996333964919453 0.07927050726079073 0.08085773378212605 0.025483908519937447 0.09728417292351248 0.5713150354067963 1.1045387901817742e-07 6.956819027582424 13.457826764292449 NYNK(ub)AVEEEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYNKAVEEEDK 11 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 5895930.0 1119800.0 934130.0 3842000.0 True False 1533820.3214571467 892857.0478451778 2934598.7284737686 1.0 0.5821131949777231 1.9132610824231788 20.548698058341483 -6.8223282808552055 1.3617951655143614 0.7752784402314079 1.9437934296210502 0.8896522639139096 0.18464266161862627 0.19047112143281053 0.6934296437329469 0.10653150300805195 0.2453957643671762 1.5054686603474192e-07 6.8223282808552055 1.1685149893896423 NYNK(ub)AVEEEDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYNKAVEEEDK 11 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 15789120.0 911520.0 3532600.0 11345000.0 True False 1179980.6087454169 3336007.7045950256 9280326.409530219 1.0 2.827171633050773 7.864812642469845 20.170331720524263 -6.953332217002742 0.5209804309944559 0.9150412614820141 10.002131884147603 0.9994374967397116 0.06884878120980203 0.0821746759871204 0.03063370623392825 0.07787569738773346 0.4161524526914448 1.1134424711026289e-07 6.953332217002742 9.08709062266559 NYPATFWVNPQFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYPATFWVNPQFK 13 0 P07384 P07384 CAPN1 Calpain-1 catalytic subunit 0 12791600.0 3204400.0 4232100.0 5355100.0 False True 4200999.43145374 3600687.176596594 4801005.621746425 1.0 0.8571025146153352 1.1428246302059257 22.00230115990011 -6.770735681954948 1.5717475602598938 0.9181146518848451 1.1444724160995468 0.7333306988317095 0.06023580887042252 0.2652399810220866 1.2932714529628817 0.030206854559705947 0.07185319573175795 1.6953693133576903e-07 6.770735681954948 0.22635776421470166 NYPATFWVNPQFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYPATFWVNPQFK 13 0 P07384 P07384 CAPN1 Calpain-1 catalytic subunit 0 8660600.0 2369300.0 1396200.0 4895100.0 False True 2294087.868389252 1953709.9410868152 3612926.4601477906 1.0 0.851628208320797 1.5748858227843445 21.129489219989885 -6.853241103683227 1.2193139814312404 0.9205456700999203 1.6056638011149726 0.9448949021802655 0.073220022664479 0.1539271482648823 0.4387477612445889 0.046946543415885854 0.10888883891520516 1.402035132192003e-07 6.853241103683227 0.6851181310150524 NYPATFWVNPQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYPATFWVNPQFK 13 0 P07384 P07384 CAPN1 Calpain-1 catalytic subunit 0 11097200.0 3204400.0 3297700.0 4595100.0 False True 4389153.275653932 3151996.7099643964 3509832.0190551304 1.0 0.7181332052011298 0.7996603897438981 22.065511221423 -10.102626403127543 7.098547806256849 1.0000001028379952 0.758896797472514 0.9210179667043306 0.03328333371591718 5.416427914349049e-08 6.8325810843714095e-09 0.03222646274283722 0.010742149765667574 7.895390174993686e-11 10.102626403127543 -0.2411033053654812 NYPATFWVNPQFK(ub)IR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYPATFWVNPQFKIR 15 1 P07384 P07384 CAPN1 Calpain-1 catalytic subunit 1 4018800.0 0.0 1711100.0 2307700.0 True False 0.0 1635497.944148976 1762668.7885733733 0.0 NYPATVHGALLSGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYPATVHGALLSGLR 15 0 R4GMQ1;O60341;O60341-2;R4GMP9 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 6132600.0 1844600.0 1293000.0 2995000.0 False True 1786044.1826829906 1809301.6429059242 2210519.651925936 1.0 1.0130217720526915 1.2376623564851008 20.76833633922856 -6.918810024952772 0.8335131914498599 0.9948276483342849 1.272913398059892 0.9938437444933013 0.008559824430641422 0.09887699717920721 0.10928251709545121 0.007329059677165362 0.021710110128726156 1.2055631790236055e-07 6.918810024952772 0.27808574972560696 NYPPWQHTTLSVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYPPWQHTTLSVLR 14 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;Q9P2J5-3 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 25455400.0 7428500.0 8391800.0 9635100.0 False True 9738835.437696323 7139776.150980191 8638152.278405445 1.0 0.7331242217466889 0.8869800022464247 23.21531783560414 -10.193861620194316 5.11875372632618 1.0000141974437762 0.8100521122250771 0.6702133665071741 0.06281135936745733 1.0177629293933892e-05 1.6028362806782259e-06 0.060821381451617154 0.02027227906516868 6.399387074889672e-11 10.193861620194316 -0.18996208521869906 NYPPWQHTTLSVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYPPWQHTTLSVLR 14 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;Q9P2J5-3 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 23106500.0 7428500.0 7096900.0 8581100.0 False True 10175017.197664218 6783335.491690066 6554420.913301991 1.0 0.6666657519996381 0.6441680427632719 23.27852789712703 -13.999999999999998 0.38297403432492133 6.039772180300266 0.6422935407643302 0.9998122682042636 0.0022291962562516945 24.41524662809725 0.2021161371123499 101.57180023273075 0.006044034194958435 1.0000000000000041e-14 13.999999999999998 -5.397478639535937 NYQFDFLRPQHSLFNYFTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYQFDFLRPQHSLFNYFTK 19 1 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 23972600.0 7925400.0 14424000.0 1623200.0 False True 10390276.14968277 12271995.424311623 1455246.8348338583 1.0 1.1811038751541079 0.14005853298502458 23.308730662484802 -6.862032209948184 1.1755103078910119 1.0988306208893575 0.0876744836017593 0.9560582950124307 0.0951951370507637 0.14471797674510095 0.3788553210389763 0.06311081411713858 0.14766437247050457 1.373940071392997e-07 6.862032209948184 -1.0111561372875981 down NYQFDFLRPQHSLFNYFTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYQFDFLRPQHSLFNYFTK 19 1 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 747865000.0 257690000.0 212682400.0 277492600.0 False True 249509772.00237456 297607591.44406426 204808963.46044132 1.0 1.192769281361982 0.8208454595457374 27.89452107864255 -6.76580524858995 1.590236726330709 1.1111545262600855 0.8190627703611002 0.7143982619358769 0.08116256526154367 0.2732471763155051 1.3629872598038386 0.04024342932153214 0.09618007544103606 1.7147260726430686e-07 6.76580524858995 -0.2920917558989853 NYQFDFLRPQHSLFNYFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NYQFDFLRPQHSLFNYFTK 19 1 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 1986911500.0 658860000.0 500102400.0 827949100.0 False True 999538789.1179974 410855219.40211415 664304597.4820185 1.0 0.4110447977358205 0.6646111233644141 29.896687313845014 -10.357967476046987 5.880978822206595 1.0000774504581975 0.5378279605501282 0.8158238185520714 0.10351801895707914 0.00010513897687986938 1.1477924832673426e-05 0.10024757599456247 0.033410296954428875 4.385635402044423e-11 10.357967476046987 -0.46224948990806936 NYQFDFLRPQHSLFNYFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYQFDFLRPQHSLFNYFTK 19 1 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 70850400.0 7925400.0 11078000.0 51847000.0 False True 10855634.55588181 10588537.329952873 39601806.42248286 1.0 0.975395521601801 3.648041597073271 23.371940724007693 -6.904820824910278 0.9302686938036836 0.9030951057534721 3.957765521062697 0.9888163436778402 0.13262865021954778 0.10794383449494536 0.15807554604767338 0.10587767954562942 0.2827803926974377 1.245028161979958e-07 6.904820824910278 3.054670415309225 up NYQFDFLRPQHSLFNYFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYQFDFLRPQHSLFNYFTK 19 1 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 868954800.0 257690000.0 340624800.0 270640000.0 False True 214280652.60261473 338789786.5936708 327229572.7020251 1.0 1.581056350532772 1.5271074113670686 27.674926354076828 -10.098468690180525 4.800732549482833 0.9999739648519174 1.55408188095546 0.9929400400176266 0.022024562205806498 6.137616092793739e-06 1.1526433987769385e-06 0.021326191117459935 0.007108396883173022 7.971339567145156e-11 10.098468690180525 0.5541079161035426 NYQFDFLRPQHSLFNYFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYQFDFLRPQHSLFNYFTK 19 1 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 1487440400.0 658860000.0 507770400.0 320810000.0 False True 852907258.0722368 479512530.87394553 262425871.78857586 1.0 0.5622094622078282 0.30768394723444803 29.667813635937463 -8.923480970732376 0.18569940289977727 1.410918663020214 1.8003659072991067e-09 0.9996913315789652 0.005023290677900418 0.40980459628307836 0.05850322952692058 0.24420394432826487 0.1449096177830846 1.1926665231931554e-09 8.923480970732376 -1.410918661219848 down NYQQNYQNSESGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYQQNYQNSESGEK 14 0 P67809;H0Y449;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 0 14995500.0 1082200.0 7746700.0 6166600.0 False True 1418774.680039707 6590922.55640009 5528539.38620409 1.0 4.645503369298662 3.8967000637827587 20.436214058088048 -10.526243163254204 6.137763463527713 0.9959553325272178 4.271101716540484 0.9621847361870627 0.30569766937055814 0.016885045721450942 0.0013033078190162807 0.29538556878663197 0.09866349853721597 2.976849212699499e-11 10.526243163254204 3.275146384013266 NYQQNYQNSESGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYQQNYQNSESGEK 14 0 P67809;H0Y449;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 0 14216700.0 3588100.0 2053400.0 8575200.0 False True 3474197.729526645 2873333.3283395404 6329097.86951428 1.0 0.8270494519985275 1.8217437124330316 21.728248434854827 -6.862046401113892 1.1752713730193887 0.9055969612514517 1.8718473807438907 0.956084565545795 0.09093264452037725 0.144713145263436 0.3786548026370351 0.06029152559691645 0.14108635760579255 1.3738951767570244e-07 6.862046401113892 0.966250419492439 NYQQNYQNSESGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYQQNYQNSESGEK 14 0 P67809;H0Y449;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 0 14558800.0 1082200.0 7372100.0 6104500.0 False True 1482318.5853553505 7046376.245725368 4662742.826123919 1.0 4.753617957259955 3.145574016402242 20.49942411961094 -9.661555328650335 8.149292532300848 0.9999555564605321 3.9495959868311084 0.8177208165644324 0.6564811903474369 0.0 0.0 0.6356351791019086 0.21187839303396946 2.1799406573970888e-10 9.661555328650335 2.949640430370576 NYQQNYQNSESGEK(ub)NEGSESAPEGQAQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 P67809;H0Y449;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 469874000.0 190800000.0 182270000.0 96804000.0 True False 250140647.70982864 155076026.48289514 86787650.68953735 1.0 0.6199553247450946 0.3469554088234946 27.898164272773197 -7.986322668273834 0.20342196134601925 1.2432723541149415 8.786222497721948e-18 0.9998339678017143 0.0034506341809037904 0.10503216958913561 0.03516692416438328 0.07630769444190788 0.10183614977982858 1.03199437879927e-08 7.986322668273834 -1.2432723541149415 down NYQQNYQNSESGEK(ub)NEGSESAPEGQAQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 P67809;H0Y449;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 607940000.0 182510000.0 250450000.0 174980000.0 True False 176716319.95092306 350455991.07949656 129147488.71252097 1.0 1.9831557785767822 0.7308181199585149 27.396860039650797 -6.697355841108815 1.84052316337271 1.6120859008448107 0.7347508644405039 0.4049341791696537 0.4152076951315423 0.4010495657026243 2.639412901740443 0.18010970490064848 0.4646739045685543 2.007447327716873e-07 6.697355841108815 -0.8773350364043069 NYQQNYQNSESGEK(ub)NEGSESAPEGQAQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 P67809;H0Y449;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 980750000.0 357010000.0 470710000.0 153030000.0 True False 541610270.92708 386708122.82598376 122783553.42456834 1.0 0.7139970262455536 0.2267009324147388 29.012679857086887 -7.165764736204007 0.44280397893637663 1.0190259337250513 4.652600086791906e-12 0.9995827357091857 0.006521195915570418 0.08361177898510011 0.0276776938110273 0.008725905199931468 0.0432736604322511 6.827084273216117e-08 7.165764736204007 -1.0190259337203988 down NYQQNYQNSESGEK(ub)NEGSESAPEGQAQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 P67809;H0Y449;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 486600000.0 190800000.0 171520000.0 124280000.0 True False 261343916.17612395 163941679.25920886 94927623.62694412 1.0 0.6273024513366742 0.3632287486002576 27.96137433429609 -8.016231897638972 0.19260679810175255 1.2658215946353202 8.497328889389278e-13 0.999860211912187 0.0030884336691093966 0.10177234168754462 0.03393563144041966 0.08247293023098444 0.10544810477602835 9.633145109561451e-09 8.016231897638972 -1.2658215946344704 down NYQQNYQNSESGEK(ub)NEGSESAPEGQAQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 P67809;H0Y449;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 525090000.0 182510000.0 286910000.0 55670000.0 True False 151765151.56390703 285364358.8828242 67310339.61100258 1.0 1.8803022692772764 0.4435164391652768 27.177265315085073 -6.740866376787629 1.683200557928592 1.5232248375319999 0.44245308769370223 0.6090269226848584 0.3698585930207819 0.31621841594777406 1.7593735661346595 0.17379827368795114 0.4261338135501579 1.8160743444271382e-07 6.740866376787629 -1.0807717498382976 NYQQNYQNSESGEK(ub)NEGSESAPEGQAQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 P67809;H0Y449;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 1026860000.0 357010000.0 546490000.0 123360000.0 True False 462156482.71919525 516077351.0966812 100909745.78048912 1.0 1.1166723185623864 0.21834540800285937 28.783806179179336 -6.8742450836659375 1.1114526352982685 1.0680170194418923 0.1613237905820164 0.9687365720043821 0.07051897664458691 0.13284688139669495 0.30416669495869153 0.049104068257734876 0.11718729768640061 1.335841453739321e-07 6.8742450836659375 -0.9066932288598759 down NYQQNYQNSESGEKNEGSESAPEGQAQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 P67809;H0Y449;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 0 25212900.0 7988700.0 2724200.0 14500000.0 False True 7735103.091293302 3811987.2665153285 10702015.009324227 1.0 0.4928166078104549 1.3835646251916804 22.882989088963125 -6.752249098034213 1.641459580748663 0.7025814359456528 1.385650357752602 0.6586241249579053 0.21314997720535186 0.29613488122371706 1.570526226777508 0.1025487815996718 0.2483817057469919 1.7690939690596065e-07 6.752249098034213 0.6830689218069492 NYQQNYQNSESGEKNEGSESAPEGQAQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NYQQNYQNSESGEKNEGSESAPEGQAQQR 29 1 P67809;H0Y449;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 0 171499300.0 3266800.0 165070000.0 3162500.0 False True 4955974.435070689 135611968.8022032 2537430.4888270074 1.0 27.363330981401425 0.5119942651178779 22.240737314814822 -8.409979206168702 7.888450189542009e-12 8.800154600952343 16.487635709707355 0.0 12.902520485491634 0.0 0.6566984555417512 589954682.41393 589954678.9478219 3.890637727529082e-09 8.409979206168702 7.687481108755012 NYQVQFVTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYQVQFVTLK 10 0 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 0 12301300.0 4010000.0 3709100.0 4582200.0 False True 5257148.832895235 3155716.737958564 4108077.8995661135 1.0 0.6002715232660888 0.7814269730886996 22.32584914833524 -10.213975085425053 5.814468093276437 1.0000083148312375 0.6908492481773895 0.7952112950454638 0.07395640269830987 7.971713942596528e-06 1.0776579621898593e-06 0.07160990414488913 0.02386932633299449 6.109770743895494e-11 10.213975085425053 -0.30915906665384807 NYQVQFVTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYQVQFVTLK 10 0 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 0 9225800.0 3482600.0 1031200.0 4712000.0 False True 3372046.7692788583 1442963.5376369604 3477785.8430300495 1.0 0.42791919459217664 1.0313575347514543 21.685193115491106 -10.102266498476222 13.54433323581556 1.0000295440536382 0.7296383646718154 0.21113711352437925 0.2463526713608921 0.0 0.0 0.23852994810178754 0.07950998270059584 7.901935884228628e-11 10.102266498476222 -0.2703911793818228 NYQVQFVTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYQVQFVTLK 10 0 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 0 11637800.0 4010000.0 3694000.0 3933800.0 False True 5492605.3661753405 3530786.8655755455 3004717.4591541113 1.0 0.6428255136112453 0.5470477594581645 22.389059209858132 -13.999999999999998 0.18473230890841671 2.8811264422936604 0.4745713095422543 0.9994931871959073 0.0043879310060299945 12.269673887757824 0.13628455397523517 8.294551701711443 0.068735840942084 1.0000000000000041e-14 13.999999999999998 -2.4065551327514063 NYQVQFVTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYQVQFVTLK 10 0 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 0 7788500.0 3482600.0 2042500.0 2263400.0 False True 2895936.205339228 2031496.6470954914 2736666.475220818 1.0 0.7014991018621294 0.9450023347113915 21.465598390925383 -9.969682021099485 6.2362810041889585 1.0000000663750326 0.8232507189763961 0.41262751578233625 0.0994097785331728 9.171366976397406e-08 1.5179359545799634e-08 0.09625314075140962 0.03208436805908998 1.0723041305312211e-10 9.969682021099485 -0.17674934739863646 NYSNTSK(ub)IFSEENSDEIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYSNTSKIFSEENSDEIIK 19 1 Q9UJX5-2;Q9UJX5;Q9UJX5-3 Q9UJX5-2 ANAPC4 Anaphase-promoting complex subunit 4 1 8368100.0 2055200.0 2784100.0 3528800.0 True False 2694387.1025851127 2368723.1323368014 3163673.6266397974 1.0 0.8791324491065686 1.1741719011364145 21.361525707006415 -6.795501313453697 1.4745135739490003 0.9329266816809456 1.177792510231189 0.8185867739144388 0.051580888800318934 0.2272492406739874 0.9758881048230217 0.027528008200677665 0.06419479642842912 1.6013958051733992e-07 6.795501313453697 0.24486582855024341 NYSWMDIITICK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYSWMDIITICK 12 0 Q9BV57;Q9BV57-2 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 0 1324380.0 366400.0 600310.0 357670.0 False True 480353.9482226474 510746.0879900531 320661.7394129043 1.0 1.0632703028253632 0.6675530420836165 18.87373832020254 -6.86596539128035 1.1553013184842282 1.0350400302372327 0.6460949908705348 0.9604837348261617 0.03450201571259152 0.14077787425419291 0.35373321548192826 0.023230242272684158 0.05464201280419515 1.3615531796648482e-07 6.86596539128035 -0.3889450393666979 NYSWMDIITICK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYSWMDIITICK 12 0 Q9BV57;Q9BV57-2 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 0 6695700.0 3174400.0 1628200.0 1893100.0 False True 3073630.4095787103 2278348.750950834 1397240.3182173565 1.0 0.7412565752377227 0.45458956739332573 21.551512267103504 -6.969803957852368 0.2628292384334041 1.077752207591617 0.10955742241600161 0.9999808114589722 0.0009757775799731543 0.076366396112082 0.009257653156875678 0.005876657078227452 0.026934346369394475 1.0720031022309284e-07 6.969803957852368 -0.9681947851756154 down NYSWMDIITICK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYSWMDIITICK 12 0 Q9BV57;Q9BV57-2 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 0 2846720.0 366400.0 969720.0 1510600.0 False True 501867.98158769245 926874.5639647869 1153827.3917835695 1.0 1.8468493667050807 2.299065559299799 18.936948381725433 -9.422560129110668 0.17240191095729518 6.605004167546281e-22 2.8765728879954544 0.9996731133269722 0.009734934052574648 0.8637865863962949 0.06702228881121344 0.750671223449319 0.31193992814468463 3.7795480493160305e-10 9.422560129110668 2.8765728879954544 NYTDEAIETDDLTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYTDEAIETDDLTIK 15 0 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 0 20662900.0 9193600.0 3786900.0 7682400.0 False True 8901754.200322207 5299028.918422616 5670148.972940168 1.0 0.5952791774716508 0.636969842723239 23.085658234249152 -10.099976227396082 7.755067479759581 1.0000000402202915 0.616124510492358 0.9912313401965739 0.017020142817262045 1.1840707505038871e-08 1.3616074395499149e-09 0.01647968413928827 0.005493227473443982 7.943717162054445e-11 10.099976227396082 -0.3838755297279336 NYTK(ub)AMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYTKAMR 7 1 Q9BV57;Q9BV57-2;A0A0G2JQN5 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 7716300.0 1937800.0 3330700.0 2447800.0 True False 2540474.5656818966 2833772.5429669153 2194525.136955595 1.0 1.1154500742684246 0.8638248800442353 21.276666589787972 -6.781957914285635 1.5282943530030915 1.065204537924881 0.8617097106506919 0.7742399537219123 0.048864394626815605 0.2475442534179575 1.1421467726696606 0.025179842632980284 0.05931606183839851 1.6521218908943194e-07 6.781957914285635 -0.203494827274189 NYTK(ub)AMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYTKAMR 7 1 Q9BV57;Q9BV57-2;A0A0G2JQN5 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 7853800.0 2257400.0 2962400.0 2634000.0 True False 2185740.07263829 4145301.768711913 1944076.381693793 1.0 1.8965209178364657 0.8894362170645489 21.05969041579967 -6.671873430232119 1.9305586345594683 1.5713143000084662 0.8934562376538328 0.28745145613458034 0.38065759714395797 0.4568274139740968 3.28421124642976 0.15862961271331344 0.42281262887358684 2.1287593562345104e-07 6.671873430232119 -0.6778580623546334 NYTK(ub)AMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYTKAMR 7 1 Q9BV57;Q9BV57-2;A0A0G2JQN5 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 6708500.0 1937800.0 2136200.0 2634500.0 True False 2654257.027075959 2041815.6205312617 2012285.359230645 1.0 0.7692607007169202 0.7581350783678487 21.339876651310863 NYTK(ub)AMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYTKAMR 7 1 Q9BV57;Q9BV57-2;A0A0G2JQN5 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 1 6923700.0 2257400.0 2415700.0 2250600.0 True False 1877128.1197762548 2402686.14462109 2721190.054401334 1.0 1.2799798369157027 1.4496560068183773 20.840095691233945 -10.535197489690255 0.07829976092665314 4.6678108213025485e-18 2.0878412232199848 0.999961336208465 0.0011528268476823404 2.5093556754946142 0.043382092581807453 0.8411612146650455 0.3738425209991209 2.916100654122763e-11 10.535197489690255 2.0878412232199848 NYTLVTVFGNLHQAQLGGVPGTYQLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYTLVTVFGNLHQAQLGGVPGTYQLVR 27 0 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 0 23755200.0 14713000.0 2106300.0 6935900.0 False True 14245943.868489036 2947356.5742093925 5119179.717460131 1.0 0.20689092989680558 0.3593429655990274 23.764047875152137 -10.015455968168524 7.096432888128098 1.0000000739090675 0.2831169479738746 0.9671946276362868 0.06223828295316932 7.289257026838235e-08 9.996556776128331e-09 0.06026196462926427 0.020087319447847262 9.650371491046352e-11 10.015455968168524 -0.7168831259351929 NYTLVTVFGNLHQAQLGGVPGTYQLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NYTLVTVFGNLHQAQLGGVPGTYQLVR 27 0 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 0 116014000.0 33642000.0 37344000.0 45028000.0 False True 51037373.5596449 30679671.42999627 36128196.06352654 1.0 0.6011216739854849 0.7078772582469447 25.605050752523354 -10.13430937683361 7.560236982883783 1.0000000985422461 0.6544994661162172 0.9331794285640465 0.04358278477221185 7.237883081552083e-08 8.275774547190548e-09 0.04219886216273776 0.014066283300343234 7.339908114206984e-11 10.13430937683361 -0.3455006324260289 NYTLVTVFGNLHQAQLGGVPGTYQLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYTLVTVFGNLHQAQLGGVPGTYQLVR 27 0 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 0 39285300.0 14713000.0 6477300.0 18095000.0 False True 12234511.396415357 6442405.499256616 21878580.83817299 1.0 0.5265764435140585 1.7882676413692575 23.544453150586413 -6.80504080767832 1.4350323348801044 0.7404378276496177 1.8079760266903382 0.846559917026996 0.2038487414092741 0.21363092610561804 0.8679021177420002 0.11172060632264366 0.2590901573679489 1.5666038601558128e-07 6.80504080767832 1.0675381990407204 NYTLVTVFGNLHQAQLGGVPGTYQLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYTLVTVFGNLHQAQLGGVPGTYQLVR 27 0 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 0 79920000.0 33642000.0 25589000.0 20689000.0 False True 43550232.18296173 24164949.655461185 16923814.287066612 1.0 0.5548753346237106 0.3886044560214253 25.376177074615804 -13.999999999999998 0.1367103307511167 3.1209279708114566 0.17444602307877222 0.9996163689207254 0.005055466898850521 11.932085142436744 0.11559221862990508 6.764739714389845 0.19106316132227943 1.0000000000000041e-14 13.999999999999998 -2.9464819477326842 NYVNGK(ub)TFLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYVNGKTFLEK 11 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 34523100.0 3388200.0 4972000.0 26162900.0 True False 4441963.011375472 4230196.980704207 23455814.08025798 1.0 0.9523260256492566 5.280506393274713 22.082765948808042 -6.9044087819374225 0.9329586392998356 0.8411631669434766 5.77781839897158 0.988635360926959 0.21632088670728022 0.10823297800613178 0.15967637103465615 0.17234786049009465 0.45920816005505327 1.2462099604229715e-07 6.9044087819374225 4.936655232028103 up NYVNGK(ub)TFLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYVNGKTFLEK 11 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 81743700.0 4808000.0 15109700.0 61826000.0 True False 4655372.671766142 21143082.006044593 45631915.85975724 1.0 4.541651871239642 9.80198988933909 22.150465232315177 -6.965420597301125 0.3507584991802574 0.49606756591139395 14.025283837450282 0.9999215553255026 0.032027961142669543 0.07781852238984406 0.01435829042158831 0.07206823613202282 0.45191404424263476 1.0828776811486505e-07 6.965420597301125 13.529216271538887 NYVNGK(ub)TFLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NYVNGKTFLEK 11 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 281128900.0 9231900.0 24327000.0 247570000.0 True False 14005467.24229493 19985656.782281473 198637680.98621437 1.0 1.4269896488656262 14.182867129655696 23.73948677878407 -6.914014853908787 0.8679483941336709 0.6534211775374205 15.981157896055473 0.9923505638353299 0.5349385162178643 0.10182233509013615 0.12480919131128174 0.44684925900098915 1.2706724352609629 1.218947907281464e-07 6.914014853908787 15.327736718518052 up NYVNGK(ub)TFLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYVNGKTFLEK 11 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 29766900.0 3388200.0 6127700.0 20251000.0 True False 4640909.102662168 5856957.9524058765 15468130.882436793 1.0 1.2620281550108674 3.332995872201806 22.145976010330934 -6.9303223669893335 0.744143086695011 0.9688798887355686 3.761663414230356 0.9966011585088729 0.060836874288807574 0.09247097595226356 0.07686329748719137 0.055531754935339406 0.18705612185908135 1.1740257785988284e-07 6.9303223669893335 2.7927835254947877 up NYVNGK(ub)TFLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYVNGKTFLEK 11 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 40230900.0 4808000.0 16121900.0 19301000.0 True False 3998065.0305148517 16035048.124753406 23336749.862258993 1.0 4.010702177770352 5.837011075143467 21.930870507749454 -8.41163877241577 0.2918629075048991 1.0584859544218434e-18 6.904976229961952 0.9988945027644864 0.06630973592960569 0.13856716686577064 0.07741917416570879 0.6557028411388398 0.5939430637130494 3.875798832691042e-09 8.41163877241577 6.904976229961952 NYVNGK(ub)TFLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYVNGKTFLEK 11 1 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 119025900.0 9231900.0 39185000.0 70609000.0 True False 11950876.537955074 37004320.30361665 57758886.50952137 1.0 3.096368721247663 4.83302511962897 23.51061310087652 -7.519591583109552 0.22291315814697746 4.5703856012041485e-15 7.021751256072306 0.9999104967732856 0.014825928131792197 0.13463849324286695 0.022920268857784167 0.19363723277729594 0.4217512369436413 3.022793063033774e-08 7.519591583109552 7.021751256072301 NYVNGK(ub)TFLEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYVNGKTFLEKR 12 2 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 2 5025800.0 1050100.0 1025300.0 2950400.0 True False 1376691.269182865 872329.2365880975 2645120.9102352276 1.0 0.6336418746273218 1.9213609975206996 20.39277363253173 -6.830682762221722 1.324874544400255 0.8043357309965897 1.956494305092078 0.9072324187153451 0.16500208003414402 0.17996837947348027 0.6175746928608327 0.09777894166271084 0.22501106161365184 1.4767848819705475e-07 6.830682762221722 1.1521585740954883 NYVNGK(ub)TFLEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYVNGKTFLEKR 12 2 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 2 13345100.0 1321100.0 1704000.0 10320000.0 True False 1279162.4036335794 2384416.086242608 7616882.406636279 1.0 1.864044846431894 5.954585895426428 20.28676801105956 -6.94103090319276 0.649901617083761 0.9547768954093331 7.091954787262471 0.998295841677759 0.08920681167162334 0.08729944698698607 0.05249134282419181 0.08753006766789101 0.3504963504884209 1.1454314328165743e-07 6.94103090319276 6.1371778918531374 NYVNGK(ub)TFLEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYVNGKTFLEKR 12 2 A0A024RA52;P25787;C9JCK5 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 2 10328800.0 1321100.0 2590100.0 6417600.0 True False 1098553.1846533215 2576146.617205403 7759490.488370207 1.0 2.3450358646207707 7.0633726220719355 20.067173286493837 -6.947891967275393 0.581526323313751 0.9439162989487785 8.698481406361 0.9990253027220565 0.08116990837154513 0.08434342946917307 0.03955190118595238 0.08490507299209477 0.3943150810481884 1.1274778865393194e-07 6.947891967275393 7.754565107412221 NYYEQWGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYYEQWGK 8 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 61140900.0 5575900.0 27260000.0 28305000.0 False True 7310058.8970924085 23192914.258647755 25376270.120732125 1.0 3.1727397255134 3.4714180115327924 22.80145159933237 -10.127845193882889 0.4503463903303417 9.434511874050126e-22 3.4796126617901857 0.9991728834392987 0.031676115896435354 1.4506805283000412 0.20626016648837722 1.9479573871451537 0.06697956335487704 7.449974841071413e-11 10.127845193882889 3.4796126617901857 NYYEQWGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYYEQWGK 8 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 52692500.0 19233000.0 5795500.0 27664000.0 False True 18622458.942611933 8109673.373133242 20417968.497789353 1.0 0.4354781180146236 1.0964163519280976 24.150540245706114 -6.680534675022391 1.8995963081932898 0.6429779457350975 1.0939266791644762 0.3265186921467107 0.23923309292548678 0.4374709806265523 3.052421217923624 0.10102732286513974 0.26630860826248637 2.0867255085291436e-07 6.680534675022391 0.4509487334293787 NYYEQWGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NYYEQWGK 8 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 210899200.0 16431000.0 184590000.0 9878200.0 False True 24927028.267003283 151648472.29174718 7925769.4402311435 1.0 6.083696406462105 0.3179588579647395 24.571207563085576 -6.673923445481138 1.923588632761244 4.233878452515124 0.34087154336884273 0.29653258300717134 2.157506528614372 0.45214412078492244 3.2290909036095288 0.9017927611649155 2.396996975823629 2.1187345786566365e-07 6.673923445481138 -3.893006909146281 NYYEQWGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYYEQWGK 8 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 69671900.0 5575900.0 31975000.0 32121000.0 False True 7637460.913031696 30562238.77281485 24534681.35276047 1.0 4.0016229373648144 3.2124133441910354 22.864661660855262 -10.776412609994566 11.735235596958425 0.9938014036921708 3.607018140777925 0.9356884277950626 0.3221934672308761 0.050946601276166494 0.0009706649619297575 0.30416792598771897 0.10398749440350069 1.673352319369577e-11 10.776412609994566 2.613216737085754 NYYEQWGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 NYYEQWGK 8 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 26884100.0 19233000.0 4715600.0 2935500.0 False True 15993091.666366909 4690196.126826691 3549299.477781535 1.0 0.2932638807223285 0.2219270389880668 23.93094552114039 -13.999999999999998 0.32412385683484735 8.426742033799412 0.20840727241290988 0.9997025179893988 0.00605707623330151 18.339115181578883 0.18175527726359533 92.56208669104264 0.023374268622296236 1.0000000000000041e-14 13.999999999999998 -8.218334761386503 NYYEQWGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYYEQWGK 8 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 44760000.0 16431000.0 12201000.0 16128000.0 False True 21270253.403431527 11522003.624459036 13192869.487254603 1.0 0.5416956444251949 0.6202497561747995 24.342333885178025 -10.765054162264429 7.033371725524454 1.0093278360918905 0.5809727002999971 0.9743187853145275 0.03206958183068333 0.004688161767364382 0.0001566052485006688 0.03103429499283953 0.010350413029172703 1.7176941546254555e-11 10.765054162264429 -0.4283551357918933 NYYEQWGK(ub)LTDCVVMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 NYYEQWGKLTDCVVMR 16 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 59472000.0 18958600.0 28832800.0 11680600.0 True False 24854908.19534359 24531058.629374128 10472003.560226943 1.0 0.9869703978214599 0.4213253767796578 24.567027438730555 -6.911862225868812 0.8829473770947309 1.0164991508018497 0.345234353434835 0.9916057046546025 0.024716538798012524 0.10319989860586055 0.13217944193797185 0.0204239059705367 0.05713464853448105 1.2250047540473632e-07 6.911862225868812 -0.6712647973670147 down NYYEQWGK(ub)LTDCVVMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 NYYEQWGKLTDCVVMR 16 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 161560800.0 77887800.0 55285200.0 28387800.0 True False 75415294.42262617 77360868.66850936 20952183.564254746 1.0 1.0257981389687378 0.27782406373485763 26.168353799775574 -6.898908837270715 0.9681138284173902 1.0320359190894002 0.2010212322483022 0.9860163600927755 0.04099548392362035 0.1122138503030497 0.18197267489447713 0.03182281523720846 0.0823558025774904 1.2620924325360095e-07 6.898908837270715 -0.8310146868410979 down NYYEQWGK(ub)LTDCVVMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 NYYEQWGKLTDCVVMR 16 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 524485000.0 110333000.0 194550000.0 219602000.0 True False 167383227.42275444 159831032.4739119 176197568.44502398 1.0 0.9548808141345716 1.052659643131432 27.31857972948216 -6.78122543560137 1.530953115316807 0.974492783986962 1.053466003423084 0.7717316414562536 0.01909071037640608 0.248684992876979 1.1513359789601754 0.009820382399501868 0.023149743961807773 1.6549107017231286e-07 6.78122543560137 0.07897321943612201 NYYEQWGK(ub)LTDCVVMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 NYYEQWGKLTDCVVMR 16 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 63439300.0 18958600.0 31221100.0 13259600.0 True False 25968106.756900754 29841648.567628767 10127955.570034036 1.0 1.1491653529843358 0.39001516994852303 24.630237500253447 -6.8556843291034 1.2072288124481099 1.0801814847890692 0.3561507123559835 0.9481851513746398 0.07475411963447526 0.1513190625654268 0.42151709505071056 0.04837113227355839 0.11242786948138912 1.3941697997547465e-07 6.8556843291034 -0.7240307724330857 down NYYEQWGK(ub)LTDCVVMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 NYYEQWGKLTDCVVMR 16 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 146734000.0 77887800.0 53569000.0 15277200.0 True False 64767156.71458702 53280413.16438604 18471591.886208158 1.0 0.8226455485637537 0.28519998133634206 25.94875907520985 -6.951224583572977 0.5452390562187608 1.0076512271310487 0.0751514139411174 0.9992938806554286 0.008075720379955525 0.08299781231832237 0.033956617701522564 0.008819816617612221 0.044547045166245525 1.118859146280669e-07 6.951224583572977 -0.9324998131899314 down NYYEQWGK(ub)LTDCVVMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 NYYEQWGKLTDCVVMR 16 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 501964000.0 110333000.0 183588000.0 208043000.0 True False 142828243.48857737 173371166.4131779 170181308.70144528 1.0 1.2138437201115841 1.1915101981566796 27.08970605157461 -10.0871766796039 4.803918896788896 0.9999918523474347 1.2026769591334605 0.990975358346685 0.00911762216665624 8.154032814253456e-07 1.5492218911597637e-07 0.008828463237501503 0.0029426998994872802 8.181318881549704e-11 10.0871766796039 0.2026851067860258 NYYEQWGK(ub)LTDCVVMRDPASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 NYYEQWGKLTDCVVMRDPASK 21 2 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 129011000.0 10201000.0 38831000.0 79979000.0 True False 15475662.792994993 31901304.662012216 64171115.59395905 1.0 2.0613853563966407 4.14658269906255 23.883497862839473 -6.960392616579384 0.4298646111057589 0.9170537427535141 5.370860371633059 0.9997844850199505 0.01918814812808531 0.07956116571204559 0.020615285637231227 0.0271869359480063 0.17314134971353753 1.0954873915067021e-07 6.960392616579384 4.453806628879545 NYYEQWGK(ub)LTDCVVMRDPASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYYEQWGKLTDCVVMRDPASK 21 2 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 1 149184000.0 10201000.0 72449000.0 66534000.0 True False 13205395.591771968 68417149.46221066 54425494.69649042 1.0 5.180999613888136 4.121458862648683 23.654624184931922 -9.929806235112398 6.151999786224178 0.9999990576598181 4.651229238268969 0.9405952498802073 0.4325557003723047 5.647726587477194e-06 9.819900111831749e-07 0.41882036821929125 0.1396067519871247 1.1754218643534526e-10 9.929806235112398 3.6512301806091507 NYYGYQGYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 NYYGYQGYR 9 0 Q1KMD3 Q1KMD3 HNRNPUL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 9597000.0 2792800.0 4331000.0 2473200.0 False True 3661387.845513668 3684831.682105773 2217296.9886096013 1.0 1.0064029918657296 0.6055892142992925 21.80395917365835 -6.903270496823589 0.9403543777211744 1.0152022158111016 0.5606062864478046 0.9881245075937718 0.020427798231024672 0.10903801096918041 0.16415132934474985 0.01618691015342233 0.04285079725353747 1.2494805588981743e-07 6.903270496823589 -0.45459592936329696 NYYGYQGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 NYYGYQGYR 9 0 Q1KMD3 Q1KMD3 HNRNPUL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 7978000.0 2203100.0 1208200.0 4566700.0 False True 2133163.7964159683 1690640.560679764 3370544.2719366127 1.0 0.7925507471673253 1.5800681961692895 21.02456331756443 -6.8367013331172215 1.2977954563720688 0.8895564916237253 1.6042968943616458 0.9186012047667038 0.09508722051581929 0.17269041829990822 0.5664407648759714 0.0574838692660929 0.13232545607882418 1.4564603526473366e-07 6.8367013331172215 0.7147404027379205 NYYGYQGYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 NYYGYQGYR 9 0 Q1KMD3 Q1KMD3 HNRNPUL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 25621300.0 3967700.0 19583000.0 2070600.0 False True 6019290.977724364 16088260.647322657 1661345.0024237786 1.0 2.6727833405729355 0.2760034377091805 22.52116212887339 -6.719052878886166 1.7626151034858366 2.018738901449434 0.27991613110568936 0.508043997203453 0.7039989080507618 0.3571860845881218 2.1682007416670084 0.3171888266188817 0.7971835236158248 1.909620732551567e-07 6.719052878886166 -1.7388227703437447 NYYGYQGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 NYYGYQGYR 9 0 Q1KMD3 Q1KMD3 HNRNPUL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 8296800.0 2792800.0 2113000.0 3391000.0 False True 3825373.632582166 2019640.673243404 2590115.639837206 1.0 0.5279590615780257 0.6770882764957136 21.86716923518124 -10.91265851394321 11.312243894271315 1.0408585622024604 0.6025236690368696 0.9045060889568803 0.06088174704836407 0.03245574267581578 0.000250589367363958 0.03049602790339825 0.019649499367193884 1.2227607398969158e-11 10.91265851394321 -0.4383348931655908 NYYGYQGYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 NYYGYQGYR 9 0 Q1KMD3 Q1KMD3 HNRNPUL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 11768900.0 3967700.0 3094100.0 4707100.0 False True 5136265.8650596645 2921910.6150675104 3850456.098924617 1.0 0.5688783820448844 0.7496605900247512 22.292288450965838 -10.19645902949393 5.4116054550359625 1.0000152744059605 0.6592694860347663 0.8256749856636999 0.07380402735424385 1.3601643631751932e-05 2.0196351939148974e-06 0.07146364271263514 0.023820147402142434 6.36122812609285e-11 10.19645902949393 -0.3407457883711942 PAAGTAAASANGAAIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PAAGTAAASANGAAIKK 17 1 A0A0G2JH30;A0A0G2JPX0;P49918-2;P49918 A0A0G2JH30 CDKN1C Cyclin-dependent kinase inhibitor 1C 1 9009560.0 728460.0 1326800.0 6954300.0 True False 605746.7662497602 1319652.2650508198 8408411.976949781 1.0 2.178554370534937 13.881067874298553 19.20835527237528 -6.926312676424503 0.7764729195004384 0.7956145556051096 16.072415465709305 0.9957623447647951 0.3784981733018435 0.09459837628281662 0.087398174655967 0.3375445987210727 1.0811400286807118 1.1849153445152656e-07 6.926312676424503 15.276800910104196 PAANTK(ub)IGPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PAANTKIGPR 10 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 47246000.0 8930000.0 13623000.0 24693000.0 True False 11707316.478243008 11590501.502038078 22138005.231981583 1.0 0.9900220536087821 1.8909547096572532 23.480907087001544 -6.904396780637228 0.933055306693395 0.966925238249072 1.994440270950929 0.9886294465245553 0.04503865910023166 0.10824119395570274 0.15973114877171593 0.03588116874896906 0.09559402320121846 1.2462443986834482e-07 6.904396780637228 1.027515032701857 PAANTK(ub)IGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PAANTKIGPR 10 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 62478000.0 11004000.0 19449000.0 32025000.0 True False 10654684.043285077 27215087.125195142 23636691.77059365 1.0 2.5542838262150966 2.218431975511301 23.344984475920203 -10.42141577533825 5.737804459490635 0.9993361466569928 2.3863579008632 0.957840148824987 0.13711094389895642 0.0011648393282237181 0.00011745888946844963 0.13281035128517638 0.044252366858618754 3.789520184741063e-11 10.42141577533825 1.387021754206207 PAANTK(ub)IGPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PAANTKIGPR 10 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 29275100.0 4206400.0 8050700.0 17018000.0 True False 6381416.329031877 6613989.684593804 13654384.840745635 1.0 1.0364454133017225 2.139710706324835 22.605445229066568 -6.913927664677459 0.8685818423927918 0.9699355143874883 2.294937990858311 0.9923206876218617 0.046346982414030076 0.10187763003158858 0.1251108991866585 0.03869763917550799 0.10996309905639401 1.2191926485907373e-07 6.913927664677459 1.3250024764708228 up PAANTK(ub)IGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PAANTKIGPR 10 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 51394000.0 8930000.0 11096000.0 31368000.0 True False 12231662.324176012 10605742.030434836 23959524.44423869 1.0 0.8670728270083513 1.9588117959144795 23.544117148524435 -6.8764462775129225 1.0993645301583568 0.9209084647726399 2.0311160606344236 0.9707069604697691 0.08324093090118782 0.1308275603808457 0.29166947904302676 0.058498763389597655 0.1402796804614396 1.329087955933146e-07 6.8764462775129225 1.1102075958617839 PAANTK(ub)IGPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PAANTKIGPR 10 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 47805000.0 11004000.0 21932000.0 14869000.0 True False 9150313.559855541 21813847.96283884 17978039.153511718 1.0 2.3839454047281 1.9647456926924745 23.12538975135448 -10.109713586509425 4.819212782259946 0.9999398388384049 2.1743455487197587 0.9127687370665377 0.17113756583411524 0.00011062691163310837 2.043704046671789e-05 0.16571164867671453 0.05523441194497822 7.767592137959305e-11 10.109713586509425 1.1744057098813538 PAANTK(ub)IGPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PAANTKIGPR 10 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 17986300.0 4206400.0 6332900.0 7447000.0 True False 5445267.720540108 5980468.547933499 6091722.412672681 1.0 1.0982873303684517 1.1187186241907041 22.376571551159017 -13.999999997693413 0.2207952750452441 0.4048157041969668 1.1295644352711802 0.9994986896391986 0.00116033273621433 13.021530753809351 0.148853123875941 3.380610772350115 0.011248283884120277 1.0000000053111127e-14 13.999999997693413 0.7247487310742134 PAASITSKPATLTTTSATSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PAASITSKPATLTTTSATSK 20 1 J3QRS9;O43670-2;O43670;O43670-4;X6R4W8;O43670-3;J3KS31 J3QRS9 ZNF207 BUB3-interacting and GLEBS motif-containing protein ZNF207 0 13909800.0 3611800.0 3924400.0 6373600.0 False True 4735104.776720958 3338894.8171913885 5714121.011888302 1.0 0.7051364171720738 1.206757037348033 22.174964918815785 -6.7473818440829065 1.6593564176244038 0.8260770730403195 1.207569763813851 0.6377257462883796 0.1238911082225588 0.30462205865030023 1.6494057418623997 0.0589987850538892 0.14363903644086665 1.7890321942530628e-07 6.7473818440829065 0.38149269077353143 PAASITSKPATLTTTSATSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PAASITSKPATLTTTSATSK 20 1 J3QRS9;O43670-2;O43670;O43670-4;X6R4W8;O43670-3;J3KS31 J3QRS9 ZNF207 BUB3-interacting and GLEBS motif-containing protein ZNF207 0 10232000.0 2030700.0 1072200.0 7129100.0 False True 1966236.5400489792 1500335.0514491335 5261774.841584361 1.0 0.7630491148393367 2.6760640108200255 20.90700545897223 -6.875884213762996 1.1025634495922663 0.8598217719957594 2.8013421442131086 0.9702080417377726 0.14696613506157086 0.13133501654001836 0.294887524632956 0.10303653490501449 0.24674956607976192 1.3308091746099119e-07 6.875884213762996 1.941520372217349 up PAASITSKPATLTTTSATSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PAASITSKPATLTTTSATSK 20 1 J3QRS9;O43670-2;O43670;O43670-4;X6R4W8;O43670-3;J3KS31 J3QRS9 ZNF207 BUB3-interacting and GLEBS motif-containing protein ZNF207 0 9666800.0 3611800.0 2926800.0 3128200.0 False True 4947180.06522497 2797484.2983666817 2389383.587301313 1.0 0.5654704824736287 0.4829789002621754 22.238174980338677 -13.999999999999979 0.23364050712077303 3.7900818681840005 0.4442352606723142 0.999514975717813 0.004994805719587549 13.407438357037318 0.15302282009434787 17.38929455319285 0.04187172868740785 1.000000000000049e-14 13.999999999999979 -3.345846607511686 PAASITSKPATLTTTSATSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PAASITSKPATLTTTSATSK 20 1 J3QRS9;O43670-2;O43670;O43670-4;X6R4W8;O43670-3;J3KS31 J3QRS9 ZNF207 BUB3-interacting and GLEBS motif-containing protein ZNF207 0 4987000.0 2030700.0 1801200.0 1155100.0 False True 1688617.0252634145 1791496.5780897944 1396626.0694210336 1.0 1.0609253319652698 0.827082783441182 20.687410734406505 -6.837512604593334 1.2939903376350996 1.0324278510667353 0.819766987680214 0.9200758745348768 0.028001722568227846 0.1717253531736281 0.559634085268947 0.016975550706781296 0.039084196117347515 1.4537421928195272e-07 6.837512604593334 -0.21266086338652124 PAASLAVHTDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PAASLAVHTDK 11 0 Q13610;B4DJV5 Q13610 PWP1 Periodic tryptophan protein 1 homolog 0 8201900.0 2886200.0 2454100.0 2861600.0 False True 3783836.15000056 2087957.846006876 2565509.0824054778 1.0 0.5518097938798346 0.6780180168227152 21.85141818688636 -10.424437362929988 8.926259736514448 1.0000028050218177 0.6149139053512801 0.9254458359931768 0.05152429125891309 2.8762499346586873e-06 1.853871997128114e-07 0.04988854384658952 0.0166293934975759 3.7632462459465326e-11 10.424437362929988 -0.3850888996705376 PAASLAVHTDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PAASLAVHTDK 11 0 Q13610;B4DJV5 Q13610 PWP1 Periodic tryptophan protein 1 homolog 0 3548300.0 736330.0 588470.0 2223500.0 False True 712955.6071966642 823449.1398305086 1641098.6464298198 1.0 1.1549795408276597 2.301824447222747 19.44345272323627 -6.93157694004483 0.7337351975855694 0.9835404437970354 2.5470061059663 0.9968391789986726 0.03264283145222642 0.09182714160536255 0.07372976772083582 0.030023202179750335 0.1028845079337786 1.1706391923380221e-07 6.93157694004483 1.5634656621692644 up PAASLAVHTDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PAASLAVHTDK 11 0 Q13610;B4DJV5 Q13610 PWP1 Periodic tryptophan protein 1 homolog 0 4961070.0 2886200.0 909770.0 1165100.0 False True 3953306.1366222664 869573.3531929264 889927.3759877095 1.0 0.21996104605647773 0.2251096538524259 21.91462824840925 -10.081238958176622 5.731979464378512 1.0000041392779315 0.22253534995462976 0.9999671096441025 0.0021019103317432334 1.1310335105659781e-07 1.8131515931862464e-08 0.0020351769443625926 0.0006783886423898091 8.293942913440455e-11 10.081238958176622 -0.7774687893233018 PAASLAVHTDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PAASLAVHTDK 11 0 Q13610;B4DJV5 Q13610 PWP1 Periodic tryptophan protein 1 homolog 0 2384400.0 736330.0 1035000.0 613070.0 False True 612291.0199498748 1029424.2495685852 741260.102484594 1.0 1.6812662868269062 1.2106336338972883 19.223857998670546 -10.57281823443776 5.596788575223436 0.9981868234042117 1.4459499603620973 0.5448639761685506 0.1921349759949898 0.004362258042089936 0.00033295465295114264 0.18668792544250798 0.06201129685437968 2.6741253779823846e-11 10.57281823443776 0.4477631369578856 PAATSIPGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PAATSIPGK 9 0 Q8N799 Q8N799 SPATA24 0 86491000.0 35489000.0 32437000.0 18565000.0 False True 46526422.675964884 27597526.0384357 16644071.888054835 1.0 0.5931581336188205 0.35773375494550985 25.471546929620708 -9.170854605634894 0.1581629055613135 1.5131705660252357 2.64078500214632e-10 0.9997912502348774 0.003833078553535193 0.6149087817349157 0.05503167093463423 0.3190516613274258 0.16997001375925327 6.747538859502446e-10 9.170854605634894 -1.5131705657611572 PAATSIPGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PAATSIPGK 9 0 Q8N799 Q8N799 SPATA24 0 99000000.0 38753000.0 29415000.0 30832000.0 False True 37522807.22731974 41160562.897198565 22756174.25982649 1.0 1.0969478548830494 0.6064624675324956 25.161264429736253 -6.855359619158221 1.2089175673151378 1.0520798960671778 0.5847270558574911 0.9477519399449392 0.04847960479237332 0.15165799594045218 0.4238328508070447 0.031330522669031344 0.07279587908052111 1.3952125716439237e-07 6.855359619158221 -0.4673528402096867 PAATSIPGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PAATSIPGK 9 0 Q8N799 Q8N799 SPATA24 0 76479000.0 36363000.0 27784000.0 12332000.0 False True 55165329.49139076 22825728.122617163 9894574.794692382 1.0 0.41376945144829425 0.1793621987925687 25.717258505751268 -10.348348728463396 0.2083944249389689 1.7307979970561915 1.3082378570830398e-14 0.9993434043198696 0.008843762913250465 1.9898275393893932 0.10295332899117758 0.907321268736276 0.13350745490474197 4.483852023540352e-11 10.348348728463396 -1.7307979970561784 PAATSIPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PAATSIPGK 9 0 Q8N799 Q8N799 SPATA24 0 83745000.0 35489000.0 28008000.0 20248000.0 False True 48610242.35416381 26770513.94992958 15465839.420649875 1.0 0.5507175577296108 0.31816009696000036 25.5347569911436 -9.895368640120559 0.1584519478508439 1.6676900350459154 2.4262241341945993e-21 0.9997026565951584 0.004880092358256674 1.4103498485424975 0.07077321684938662 0.586032090930548 0.18516633209307895 1.272422558102723e-10 9.895368640120559 -1.6676900350459154 PAATSIPGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PAATSIPGK 9 0 Q8N799 Q8N799 SPATA24 0 101207000.0 38753000.0 45183000.0 17271000.0 False True 32224836.54898961 44939590.21087671 20882286.2479185 1.0 1.3945637906512753 0.6480183760178996 24.94166970517053 -6.7630719451200365 1.6006139132284782 1.2282992416875385 0.644838472444648 0.7035313235124958 0.16603719145254534 0.2777661277005927 1.403148142637265 0.08181592562668755 0.19604789724902894 1.7255520137775596e-07 6.7630719451200365 -0.5834607692428905 PAATSIPGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PAATSIPGK 9 0 Q8N799 Q8N799 SPATA24 0 72779200.0 36363000.0 30375000.0 6041200.0 False True 47072620.32189042 28684604.54822909 4941763.587946589 1.0 0.609369190669204 0.10498169751660277 25.488384827843717 -7.592644131546736 0.5007829162650652 1.015936861989741 1.7814922607121876e-22 0.9963640313619342 0.02209187087027411 0.11778338432326058 0.08083307523166296 0.025563278625573095 0.07254331225674997 2.554793887747519e-08 7.592644131546736 -1.015936861989741 down PAAVVLQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PAAVVLQTK 9 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 23504900.0 7062000.0 8198100.0 8244800.0 False True 9258350.388505273 6974975.4359435085 7391707.185706134 1.0 0.7533712965328366 0.7983827437427002 23.14232373275256 -10.431883856875794 5.981581549029966 1.0000895887235066 0.7758770201377712 0.9706375971507357 0.018375846374731507 2.196298578975339e-05 2.0859684371935e-06 0.017799421792689868 0.005930778915150052 3.6992709594422677e-11 10.431883856875794 -0.22421256858573546 PAAVVLQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PAAVVLQTK 9 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 12053200.0 2998200.0 1736000.0 7319000.0 False True 2903023.782131706 2429193.853120406 5401934.334706477 1.0 0.8367805555270499 1.860795756464595 21.469124960173673 -6.8661038749395145 1.1545884457964082 0.9095520630403044 1.9164686406621085 0.9606331335202964 0.08913084884435166 0.1406408444027557 0.352870892645827 0.06004484032687959 0.141265282227621 1.3611190898581567e-07 6.8661038749395145 1.006916577621804 PAAVVLQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PAAVVLQTK 9 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 17069700.0 7062000.0 3605900.0 6401800.0 False True 9673012.243374126 3446579.4148832895 4889826.689209612 1.0 0.3563088031077544 0.5055123022881598 23.20553379427545 -10.17980981433918 8.045305342032796 1.0000001433837893 0.43091055269953005 0.9509739568734744 0.06091207347162689 1.5669181804893544e-07 1.5948493918864223e-08 0.05897787647448113 0.019659287178214455 6.609828413627288e-11 10.17980981433918 -0.5690895906842592 PAAVVLQTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PAAVVLQTK 9 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 8409800.0 2998200.0 3281600.0 2130000.0 False True 2493136.1427807035 3263921.369453402 2575373.1519927285 1.0 1.3091629106996971 1.0329853664229913 21.24953023560795 -9.765652285408924 5.62703271946254 0.9999999806148407 1.1710741385636398 0.3384494261773101 0.1127490103235775 2.748534969256108e-08 5.926427872457234e-09 0.10916877120479326 0.03638958660587007 1.7153301239531435e-10 9.765652285408924 0.1710741579487991 PADSEK(ub)NNAVEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PADSEKNNAVEDR 13 1 G5EA30;Q92879-2;Q92879-3;Q92879 G5EA30 CELF1 CUGBP Elav-like family member 1 1 6927000.0 1654700.0 3015900.0 2256400.0 True False 2169327.724137595 2565939.4758861274 2022929.3729171522 1.0 1.1828270331566446 0.9325144146771818 21.048816589264963 -6.710914267697713 1.7923072716955617 1.1122934899229429 0.9330951074631496 0.4693352033424564 0.07703117212249784 0.3732114838327437 2.3376764155082608 0.0341977369557826 0.08677039438857567 1.9457441451286667e-07 6.710914267697713 -0.17919838245979325 PADSEK(ub)NNAVEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PADSEKNNAVEDR 13 1 G5EA30;Q92879-2;Q92879-3;Q92879 G5EA30 CELF1 CUGBP Elav-like family member 1 1 7448400.0 2001100.0 2381800.0 3065500.0 True False 1937576.1758467585 3332865.1609229147 2262553.5869712704 1.0 1.7201208409090742 1.1677236823901855 20.885821600410917 -10.221834678224553 4.265768246191286 0.9997997557590206 1.443922261619989 0.4626811397099363 0.2255151957979211 23564418.066761002 56466317.27927247 27714.051800593163 0.07719984816289815 6.000194406611448e-11 10.221834678224553 0.44412250586096835 PADSEK(ub)NNAVEDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PADSEKNNAVEDR 13 1 G5EA30;Q92879-2;Q92879-3;Q92879 G5EA30 CELF1 CUGBP Elav-like family member 1 1 8361500.0 2628600.0 1730800.0 4002100.0 True False 3987778.3764010076 1421925.2171978776 3211083.180817257 1.0 0.3565707727421836 0.8052311030672867 21.92715380249263 -9.897002663727912 6.95717646937447 1.0000000088832028 0.5809009379047322 0.5377690432620028 0.1831648128541863 2.5099899087412735e-08 4.17837561988274e-09 0.1773485700915566 0.05911618914962021 1.267644090789445e-10 9.897002663727912 -0.41909907097847066 PADSEK(ub)NNAVEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PADSEKNNAVEDR 13 1 G5EA30;Q92879-2;Q92879-3;Q92879 G5EA30 CELF1 CUGBP Elav-like family member 1 1 5898500.0 1654700.0 2226700.0 2017100.0 True False 2266487.306586121 2128317.031287782 1540702.5234785099 1.0 0.9390377016907026 0.6797754917935901 21.112026650787854 -6.9434691657564 0.6264613679134239 1.0028291693297087 0.6020957885142252 0.9985838623096754 0.005224589961172543 0.08621911136077008 0.047666500189587666 0.005230969308319703 0.02199609261768411 1.1390186475859031e-07 6.9434691657564 -0.4007333808154835 PADSEK(ub)NNAVEDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PADSEKNNAVEDR 13 1 G5EA30;Q92879-2;Q92879-3;Q92879 G5EA30 CELF1 CUGBP Elav-like family member 1 1 7397100.0 2001100.0 4104300.0 1291700.0 True False 1664003.313761077 4082189.3212602385 1561788.497853995 1.0 2.453233889320471 0.9385729493073846 20.666226875845194 -6.655551152533966 1.9885225943241929 1.9388160452110463 0.9448982546574729 0.2169679208786197 0.619413851450276 0.49505318499510104 3.7581869028103356 0.2520690240220089 0.6864305479300911 2.2102879064893832e-07 6.655551152533966 -0.9939177905535734 PADSEK(ub)NNAVEDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PADSEKNNAVEDR 13 1 G5EA30;Q92879-2;Q92879-3;Q92879 G5EA30 CELF1 CUGBP Elav-like family member 1 1 7275500.0 2628600.0 1574400.0 3072500.0 True False 3402774.5174523895 1486783.2559911706 2513336.5265122657 1.0 0.4369326408099191 0.7386138909944483 21.69828012458508 -10.082041977011436 5.300300991882503 1.000005619301492 0.5877732659017523 0.7134270627577113 0.123160854654386 8.178238127727613e-06 1.4164995835272898e-06 0.11925160832555333 0.03974999491486861 8.278621422992946e-11 10.082041977011436 -0.4122323533997396 PAINVGLSVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PAINVGLSVSR 11 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 12402600.0 5540500.0 2526500.0 4335600.0 False True 5364619.860216372 3535344.6255234485 3199976.294788006 1.0 0.6590112100470167 0.596496374052297 22.355044513798777 -13.999999999999998 0.23858372223649546 3.241630550406153 0.5684815248391657 0.9995226413620318 0.003874282567743257 13.573977528962331 0.1546043823781552 14.484979655372383 0.03080371069556576 1.0000000000000041e-14 13.999999999999998 -2.673149025566987 PAINVGLSVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PAINVGLSVSR 11 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 27228300.0 7530200.0 10002000.0 9696100.0 False True 11423863.931360748 8217064.954017317 7779661.585048392 1.0 0.7192894631263824 0.6810008970512766 23.44554736497969 -13.99999999905629 0.2807159262736372 3.2968107531604813 0.669555468647102 0.9996067618366592 0.0028201421718649887 15.436993317174254 0.16784763593620924 20.363891148217895 0.015094579835448213 1.0000000021729746e-14 13.99999999905629 -2.6272552845133794 PAINVGLSVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PAINVGLSVSR 11 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 3975150.0 1232700.0 821650.0 1920800.0 False True 1688462.5024649247 785346.7861667967 1467146.6001177542 1.0 0.4651253936763758 0.8689245973635307 20.6872787095173 -9.794684092713352 6.213411984165965 1.0000000107966083 0.6670249955196893 0.47551496412589167 0.1648503345969101 2.476882261997158e-08 4.593531679321838e-09 0.15961565726258695 0.053205216709071725 1.6044120211067307e-10 9.794684092713352 -0.332975015276919 PAINVGLSVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PAINVGLSVSR 11 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 9550900.0 5540500.0 1683600.0 2326800.0 False True 4607171.235766958 1674530.112631563 2813323.1220923387 1.0 0.3634616616008637 0.6106400170785063 22.135449789233054 -10.28364306477157 5.653093982654197 1.0000457552827577 0.4870508393397191 0.851677025368298 0.10091014106344244 5.819720768443794e-05 7.374847190535782e-06 0.09771450435272883 0.032568607983509086 5.204235432566125e-11 10.28364306477157 -0.5129949159430387 PAINVGLSVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PAINVGLSVSR 11 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 22596000.0 7530200.0 9716100.0 5349700.0 False True 9747992.342433227 9175390.493861685 4376109.492557415 1.0 0.9412595098091128 0.44892418241940063 23.216673687072138 -6.929239363394705 0.7530096739377344 1.0077020307795506 0.34978066060515384 0.9963866286142204 0.014853553042152695 0.09303470549467432 0.07962922287591288 0.013471578185326454 0.0447356345261 1.1769571094184553e-07 6.929239363394705 -0.6579213701743967 down PALLHSTFFPALQGAQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PALLHSTFFPALQGAQTK 18 0 P23381;P23381-2;H0YJP3 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 17813400.0 6325500.0 7308600.0 4179300.0 False True 8292791.756229131 6218185.36869967 3746866.1266764086 1.0 0.7498301599131414 0.4518220445921544 22.983426433993248 -6.96880428353522 0.28530551443447477 1.0615970491506443 0.13090778171264345 0.9999714940983242 0.0011963515529137326 0.07669264101300283 0.010412358314405772 0.005341706510157722 0.0271749568263886 1.0744735188404146e-07 6.96880428353522 -0.930689267438001 down PALLHSTFFPALQGAQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PALLHSTFFPALQGAQTK 18 0 P23381;P23381-2;H0YJP3 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 18386100.0 6314100.0 5037400.0 7034600.0 False True 6113662.3516636 7048860.089693964 5192027.226523602 1.0 1.152968496497993 0.8492499140242494 22.543605445881443 -6.7697998960748205 1.5754743228993369 1.0877620550296905 0.8475648461614959 0.7297029919103151 0.06446444064834361 0.2667534241527923 1.3067149818679495 0.03225449136112189 0.07678520828185327 1.699026309242491e-07 6.7697998960748205 -0.24019720886819462 PALLHSTFFPALQGAQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PALLHSTFFPALQGAQTK 18 0 P23381;P23381-2;H0YJP3 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 22653500.0 6325500.0 6167000.0 10161000.0 False True 8664208.290210005 5894521.548458151 7761181.072363854 1.0 0.6803300833751399 0.8957749874427058 23.04663649551614 -10.141016288510828 5.029195352984219 1.000010144516097 0.7880525354084972 0.5633941223043006 0.08795501377621243 1.0004889933646633e-05 1.7089382159384552e-06 0.08516615091939282 0.028387358630681273 7.227426961359433e-11 10.141016288510828 -0.21195760910759975 PALLHSTFFPALQGAQTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PALLHSTFFPALQGAQTK 18 0 P23381;P23381-2;H0YJP3 P23381 WARS Tryptophan--tRNA ligase, cytoplasmic;T1-TrpRS;T2-TrpRS 0 12601400.0 6314100.0 3536400.0 2750900.0 False True 5250453.912057782 3517348.711279558 3326100.471275498 1.0 0.6699132627756031 0.6334881758769534 22.32401072131572 -13.999999999999998 0.31121336960304935 4.213475990213642 0.6255259836739723 0.9996746593704191 0.002973641326084143 17.35655913098091 0.1775469536043828 36.1419409468796 0.012560132662910978 1.0000000000000041e-14 13.999999999999998 -3.5879500065396694 PANK(ub)QEDEVMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PANKQEDEVMR 11 1 O15145 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 1 2275870.0 729980.0 754460.0 791430.0 True False 957010.8491363751 641897.5088620466 709540.4155326282 1.0 0.6707316948823592 0.7414131367193287 19.868175754327346 -10.099908344384826 5.142494804814735 1.0000069107229796 0.7060724158002978 0.9584325901470175 0.028855577799371052 2.2863249506187717e-06 4.0019595666529964e-07 0.027939949849100247 0.009313097688238991 7.944958913008698e-11 10.099908344384826 -0.29393449492268187 PANK(ub)QEDEVMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PANKQEDEVMR 11 1 O15145 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 1 8202600.0 1650600.0 2280900.0 4271100.0 True False 1598202.6064927601 3191675.2647363623 3152370.779746528 1.0 1.9970404576804328 1.9724475275787308 20.608018881753996 -10.592990153291966 6.519660618842245 0.9978134607835157 1.9847439926295818 0.9995324455725279 0.010040021671517137 0.0003194571641069374 1.9943066807181175e-05 0.009732270002665787 0.003240403060778943 2.5527591804156832e-11 10.592990153291966 0.986930531846066 PANK(ub)QEDEVMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PANKQEDEVMR 11 1 O15145 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 1 2180390.0 729980.0 302510.0 1147900.0 True False 999873.3329677494 289144.1079332046 876789.6617425915 1.0 0.2891807375990203 0.8769007361564188 19.931385815850238 -10.368108634863916 8.21085024349513 1.0000027022669977 0.583040736877987 0.4015905556558784 0.239935684682482 1.186887727037356e-05 9.136439948237026e-07 0.23231823300853138 0.07743890924467724 4.2844133624032174e-11 10.368108634863916 -0.41696196538901076 PANK(ub)QEDEVMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PANKQEDEVMR 11 1 O15145 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 1 6595200.0 1650600.0 2780200.0 2164400.0 True False 1372547.03397833 2765222.5107735097 2616966.0329451007 1.0 2.014665029553492 1.9066494394438491 20.388424157188272 -10.37308709392627 6.874468856485055 0.9999529206424252 1.9606572344986524 0.9906071218879544 0.04409718000570716 3.182352740955114e-05 2.9021021004806803e-06 0.04269897907301742 0.014232303648067856 4.2355801670899566e-11 10.37308709392627 0.9607043138562271 PAPAVGEAEDK(ub)ENQQATSGPNQPSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PAPAVGEAEDKENQQATSGPNQPSVR 26 1 P16989;P16989-3;P16989-2 P16989;P16989-2 YBX3 Y-box-binding protein 3 1 12316300.0 3879900.0 5911400.0 2525000.0 True False 5086586.473005053 5029442.162456722 2263737.221510287 1.0 0.9887656858186525 0.44504054605660065 22.278266380726404 -6.911363682863066 0.886381040754317 1.0161176834486296 0.37268052428843346 0.991426374788785 0.023982094954487297 0.10352376540579983 0.13392135768773433 0.019767768598282165 0.05509874382436326 1.226411790619587e-07 6.911363682863066 -0.6434371591601962 down PAPAVGEAEDK(ub)ENQQATSGPNQPSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PAPAVGEAEDKENQQATSGPNQPSVR 26 1 P16989;P16989-3;P16989-2 P16989;P16989-2 YBX3 Y-box-binding protein 3 1 14813700.0 5303500.0 5419900.0 4090300.0 True False 5135143.295489123 7584094.334405117 3018927.7236302686 1.0 1.4769002339364574 0.5878955172063441 22.291973104642153 -6.7609991249151005 1.6086650222557086 1.2766747053313534 0.5844863633609085 0.6949949598243019 0.20061625871919722 0.28127181761805564 1.4347878224270427 0.09838473567392356 0.23620552928609276 1.7338074912989306e-07 6.7609991249151005 -0.6921883419704449 PAPAVGEAEDK(ub)ENQQATSGPNQPSVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PAPAVGEAEDKENQQATSGPNQPSVR 26 1 P16989;P16989-3;P16989-2 P16989;P16989-2 YBX3 Y-box-binding protein 3 1 25675500.0 8841200.0 11678000.0 5156300.0 True False 13412746.778298937 9593969.659369554 4137155.044913424 1.0 0.7152874663146592 0.3084495005606984 23.677101379279286 -7.040674474128548 0.3532241658465411 1.0398955002656782 2.7759300205717026e-16 0.9999229613445708 0.002490847534396832 0.07291570695567996 0.014539055239877635 0.005752357964994686 0.03308492237883467 9.105955547236195e-08 7.040674474128548 -1.039895500265678 down PAPAVGEAEDK(ub)ENQQATSGPNQPSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PAPAVGEAEDKENQQATSGPNQPSVR 26 1 P16989;P16989-3;P16989-2 P16989;P16989-2 YBX3 Y-box-binding protein 3 1 11883400.0 3879900.0 4980200.0 3023300.0 True False 5314403.880355049 4760158.296680925 2309258.8068179935 1.0 0.8957087951627238 0.43452828554379924 22.341476442249295 -6.942577943774062 0.6351297968128184 1.0050357273877473 0.3001268513366129 0.9984824173400199 0.009571580153102414 0.08661004998369598 0.0494003816912911 0.009510415115441886 0.03926430382307749 1.1413584441567354e-07 6.942577943774062 -0.7049088760511344 down PAPAVGEAEDK(ub)ENQQATSGPNQPSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PAPAVGEAEDKENQQATSGPNQPSVR 26 1 P16989;P16989-3;P16989-2 P16989;P16989-2 YBX3 Y-box-binding protein 3 1 14636800.0 5303500.0 8194300.0 1139000.0 True False 4410095.234886748 8150155.67945879 1377159.6338590232 1.0 1.8480679544028233 0.31227435248218377 22.07237838007643 -6.756808796738146 1.6245157273492876 1.4945619355223876 0.30754021883469473 0.6777712817790571 0.35655530005338687 0.2883229370155115 1.49889945454442 0.17323841180854202 0.4176361200097415 1.7506172488550152e-07 6.756808796738146 -1.1870217166876929 PAPAVGEAEDK(ub)ENQQATSGPNQPSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PAPAVGEAEDKENQQATSGPNQPSVR 26 1 P16989;P16989-3;P16989-2 P16989;P16989-2 YBX3 Y-box-binding protein 3 1 28274800.0 8841200.0 16717000.0 2716600.0 True False 11445107.686106697 15786684.254575998 2222206.674669883 1.0 1.379339075484591 0.19416214644860325 23.448227701371735 -6.820591343144869 1.369288667323919 1.2043465936675881 0.16795730240815446 0.88572752355766 0.16705336259784806 0.19272638770568065 0.7098729765052187 0.09586541392432377 0.22092295408725635 1.511501758769322e-07 6.820591343144869 -1.0363892912594337 down PAPQPPVPRPEHCEGAAAGLK(ub)AAQGPPAPAVPPNTDVMACTQTALLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PAPQPPVPRPEHCEGAAAGLKAAQGPPAPAVPPNTDVMACTQTALLQK 48 2 O60232;G3V1B8;H0YEB6 O60232 SSSCA1 Sjoegren syndrome/scleroderma autoantigen 1 1 85691000.0 24237000.0 43730000.0 17724000.0 True False 31774941.711441845 37205654.45820494 15890090.500613201 1.0 1.1709118083073478 0.5000824437355722 24.921386142936942 -6.839139054881151 1.2863721499089142 1.090933492217626 0.47838918231684296 0.9229695725966143 0.07899789018897363 0.16980360117704968 0.5461822110792877 0.04816128361314537 0.11093093853598816 1.4483080517751525e-07 6.839139054881151 -0.612544309900783 PAPQPPVPRPEHCEGAAAGLK(ub)AAQGPPAPAVPPNTDVMACTQTALLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PAPQPPVPRPEHCEGAAAGLKAAQGPPAPAVPPNTDVMACTQTALLQK 48 2 O60232;G3V1B8;H0YEB6 O60232 SSSCA1 Sjoegren syndrome/scleroderma autoantigen 1 1 90267000.0 24237000.0 45663000.0 20367000.0 True False 33198073.880297188 43645457.6726519 15556734.07153182 1.0 1.3146984921482194 0.46860351379495624 24.984596204459834 -6.805983671913011 1.4313280137185063 1.1723379731794774 0.45511936760719957 0.8490930575022926 0.13564221491925843 0.21232427833566073 0.8580368327330093 0.07453165037009923 0.17274345809826158 1.5632064131101889e-07 6.805983671913011 -0.7172186055722778 down PAPQPPVPRPEHCEGAAAGLK(ub)AAQGPPAPAVPPNTDVMACTQTALLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 PAPQPPVPRPEHCEGAAAGLKAAQGPPAPAVPPNTDVMACTQTALLQK 48 2 O60232;G3V1B8;H0YEB6 O60232 SSSCA1 Sjoegren syndrome/scleroderma autoantigen 1 1 204913100.0 146253900.0 35540000.0 23119200.0 True False 121616597.99634264 35348538.96586231 27953317.82889686 1.0 0.290655548241247 0.2298478849880137 26.85776489752593 -13.999999999999998 0.347906821085194 9.611567750601113 0.2212125576327272 0.9997507010211371 0.00551995296570509 20.453252442479062 0.18972687245819672 130.0383757401602 0.01827352707938761 1.0000000000000041e-14 13.999999999999998 -9.390355192968386 PASESPHHHTAPAK(ub)SPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PASESPHHHTAPAKSPK 17 1 P0DN79;P35520;P35520-2;C9JMA6 P0DN79 CBS Cystathionine beta-synthase 1 21143200.0 10439000.0 10406000.0 298200.0 True False 13685630.091419818 8853465.362270294 267345.12453638314 1.0 0.6469168977335548 0.019534732617389295 23.706158522651368 -7.53039667115101 0.6665451298150676 0.9965740289172258 8.203360775317546e-18 0.9895468389140354 0.04145462510802282 0.11838403370388265 0.1282099225751851 0.03757335604940728 0.07479104913295925 2.9485149140509124e-08 7.53039667115101 -0.9965740289172258 down PASGPIRPIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PASGPIRPIVR 11 1 P26373;J3QSB4;P26373-2 P26373 RPL13 60S ribosomal protein L13 0 24611300.0 6353300.0 2390000.0 15868000.0 False True 6151617.969120589 3344339.4636853505 11711694.770203916 1.0 0.5436520083777966 1.9038397424861826 22.552534480431316 -6.816250824493619 1.3882489895451373 0.7530635910296801 1.9311574130327742 0.8754849767277537 0.19944836591191825 0.19840304705529066 0.7523590822903239 0.11293296658018175 0.2605591783537108 1.5266840752130317e-07 6.816250824493619 1.178093822003094 PAVAILSFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PAVAILSFK 9 0 O75717;O75717-2 O75717 WDHD1 WD repeat and HMG-box DNA-binding protein 1 0 6376600.0 2412900.0 1916200.0 2047500.0 False True 3163335.2665568385 1630310.4292891 1835644.341006856 1.0 0.5153770599420612 0.5802876351468367 21.59301503753047 -10.434624864106883 6.008467921902945 1.0001812429499954 0.5478323475446297 0.9847793861463491 0.02649963136037607 6.436321457417126e-05 6.056368125714459e-06 0.025668279955281297 0.008552719244947622 3.6759968951176575e-11 10.434624864106883 -0.4523488954053657 PAVAILSFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PAVAILSFK 9 0 O75717;O75717-2 O75717 WDHD1 WD repeat and HMG-box DNA-binding protein 1 0 5690960.0 2102900.0 972860.0 2615200.0 False True 2036144.590569262 1361328.0713978768 1930200.6656817035 1.0 0.6685812381414814 0.947968368563679 20.957408582943337 -10.063240317757986 6.834501318010708 1.0000000759265566 0.8082748045460104 0.38570829347092705 0.11405931837246716 1.3196919395692194e-07 1.8058900420393203e-08 0.11043750456639101 0.03681248671136118 8.644894193740783e-11 10.063240317757986 -0.19172527138054618 PAVAILSFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PAVAILSFK 9 0 O75717;O75717-2 O75717 WDHD1 WD repeat and HMG-box DNA-binding protein 1 0 8712800.0 2412900.0 2799600.0 3500300.0 False True 3305014.3361706957 2675904.4149608323 2673601.2309413613 1.0 0.8096498661670642 0.8089529905153418 21.656225099053362 PAVAILSFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PAVAILSFK 9 0 O75717;O75717-2 O75717 WDHD1 WD repeat and HMG-box DNA-binding protein 1 0 4483600.0 2102900.0 751700.0 1629000.0 False True 1748654.524265739 747650.4428992317 1969616.3683550043 1.0 0.42755754926100714 1.1263610627616953 20.737813858377613 -6.688924613364554 1.8697548751541664 0.6407734879879651 1.1239502958238752 0.36568268492799416 0.24215278645602858 0.41894552198244406 2.838685126501978 0.10362811880301642 0.27026920436438406 2.0467998978960757e-07 6.688924613364554 0.4831768078359101 PAVAILSFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PAVAILSFK 9 0 O75717;O75717-2 O75717 WDHD1 WD repeat and HMG-box DNA-binding protein 1 0 3726000.0 1999500.0 0.0 1726500.0 False True 2588392.1660374515 0.0 1412294.7153859811 1.0 0.0 0.5456262516618768 21.303624785238462 -10.384393807883933 9.503078936838618 1.0000010268137856 0.2728131258309384 0.7031160461674815 0.2227509844731667 4.845826606882894e-06 3.1384140467520826e-07 0.21567801529652192 0.07189257110132352 4.126731301225449e-11 10.384393807883933 -0.7271879009828471 PAVVYIGSAGKPHER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PAVVYIGSAGKPHER 15 1 Q9BUQ8 Q9BUQ8 DDX23 Probable ATP-dependent RNA helicase DDX23 0 3830720.0 1424100.0 1509600.0 897020.0 False True 1184202.2483269959 1501467.4851678605 1084582.7346481315 1.0 1.267914739470464 0.9158762670653567 20.175484067301493 -6.703262070848522 1.8193508436641417 1.1658294615058675 0.9168604119500252 0.4330499800195179 0.1130239098662328 0.3887592035302576 2.503961719420769 0.049520064900579225 0.12683682618890496 1.980331652990758e-07 6.703262070848522 -0.24896904955584231 PCSEETPAISPSK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 PCSEETPAISPSKR 14 1 P33316-2;H0YNJ9 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 11161820.0 5322500.0 4946200.0 893120.0 True False 6977849.04316332 4208246.240136593 800708.5098119868 1.0 0.6030864545944429 0.11475004759475216 22.734350956332616 -7.61155338142791 0.48098398824154526 1.020119757939623 4.7903329344313845e-21 0.9968186311892211 0.020420571798556428 0.11814081528120396 0.07729878794854565 0.025366983000118037 0.07292250726091948 2.445944613606242e-08 7.61155338142791 -1.020119757939623 down PCSEETPAISPSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 PCSEETPAISPSKR 14 1 P33316-2;H0YNJ9 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 26004700.0 12115000.0 11527000.0 2362700.0 True False 11730415.956415726 16129791.212510895 1743837.990519334 1.0 1.375040004756951 0.14865951872453212 23.4837508359427 -6.824646844374382 1.3517892499780322 1.2012492900927514 0.11915475862828123 0.8947046019006482 0.1664971219157083 0.18751698261973562 0.6720150230146799 0.09675841164920125 0.22276933816578945 1.497452846182867e-07 6.824646844374382 -1.08209453146447 down PCSEETPAISPSK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PCSEETPAISPSKR 14 1 P33316-2;H0YNJ9 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 11430340.0 5322500.0 5646500.0 461340.0 True False 7290372.085154183 5397018.959521471 352380.99359554617 1.0 0.7402940338959846 0.04833511780737783 22.797561017855507 -7.31038067391658 0.709362689751858 0.9941298690241366 2.4844497320830957e-18 0.9930875316224975 0.033393867374946054 0.10184129141293487 0.10043733128593663 0.029649877059469514 0.06560561633617919 4.893496996353721e-08 7.31038067391658 -0.9941298690241366 down PCSEETPAISPSK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PCSEETPAISPSKR 14 1 P33316-2;H0YNJ9 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 23123260.0 12115000.0 10404000.0 604260.0 True False 10074159.28550071 10347951.586967697 730607.97221743 1.0 1.0271776823958942 0.07252297204283453 23.264156111376977 -6.929224405966103 0.9980412119663264 1.0366923217095068 5.289512640949872e-15 0.9866257069582787 0.05131980167066338 0.10257945205082557 0.18305265258816908 0.039888549114391283 0.09428579809697894 1.1769976454045686e-07 6.929224405966103 -1.0366923217095014 down PCSEETPAISPSK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PCSEETPAISPSKR 14 1 P33316-2;H0YNJ9 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 13630500.0 7199500.0 4907500.0 1523500.0 True False 9319894.673361667 4634393.310960799 1246238.6324300852 1.0 0.49725812076041237 0.133718102629648 23.151882220010872 -8.151409878978203 0.36097514649806406 1.0921612623317192 3.0737557058691713e-20 0.998067387831653 0.015614098756097268 0.09447737402318918 0.08465223930953078 0.06385902563098386 0.08640601953590414 7.056512594839685e-09 8.151409878978203 -1.0921612623317192 PDPAK(ub)SAPAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PDPAKSAPAPK 11 1 Q93079;Q5QNW6;Q5QNW6-2 Q93079 HIST1H2BH;HIST2H2BF Histone H2B type 1-H;Histone H2B type 2-F 1 2784430.0 950980.0 1283300.0 550150.0 True False 1246743.9893034196 1091836.642264221 493225.7554114389 1.0 0.8757504761456694 0.3956110954960479 20.249733816944765 -6.945668988595916 0.6045366444409178 1.0053586812182898 0.24123260801628982 0.9988159761849792 0.008967493111227083 0.08527313500608154 0.0435309875497181 0.0091630270984157 0.040410344977945524 1.1332637873252072e-07 6.945668988595916 -0.7641260732019999 down PDPAK(ub)SAPAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PDPAKSAPAPK 11 1 Q93079;Q5QNW6;Q5QNW6-2 Q93079 HIST1H2BH;HIST2H2BF Histone H2B type 1-H;Histone H2B type 2-F 1 6416800.0 2666400.0 2140800.0 1609600.0 True False 2581756.591513569 2995632.604124515 1187997.4730350515 1.0 1.1603079136009133 0.4601508433986728 21.299921558826878 -6.846493383467053 1.2519605719316373 1.085352218761811 0.43400850352844755 0.935035838875451 0.07633928872729363 0.16135726434254719 0.4884681850736331 0.04775464013547263 0.11028326858100043 1.4239889411378055e-07 6.846493383467053 -0.6513437152333634 down PDPAK(ub)SAPAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PDPAKSAPAPK 11 1 Q93079;Q5QNW6;Q5QNW6-2 Q93079 HIST1H2BH;HIST2H2BF Histone H2B type 1-H;Histone H2B type 2-F 1 3621220.0 1070700.0 768520.0 1782000.0 True False 1624330.1786550097 631371.6015258334 1429786.9189216543 1.0 0.38869659002988327 0.8802317027105643 20.6314134892187 -10.068137264353558 7.236069291372869 1.0000000660551456 0.6344641463702492 0.42441969542242786 0.20066836945485048 2.1394820523065198e-07 2.7607762874053862e-08 0.19429635089020295 0.06476543775076939 8.547965007630473e-11 10.068137264353558 -0.3655359196848964 PDPAK(ub)SAPAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PDPAKSAPAPK 11 1 Q93079;Q5QNW6;Q5QNW6-2 Q93079 HIST1H2BH;HIST2H2BF Histone H2B type 1-H;Histone H2B type 2-F 1 3204780.0 950980.0 1425000.0 828800.0 True False 1302583.0052681863 1362038.7881551571 633054.5096718002 1.0 1.045644525259816 0.4859993621223868 20.312943878467657 -6.887134291614226 1.0392204088687336 1.0321687212169142 0.4404887272264407 0.9789984802701589 0.03677260286256356 0.1214976429424978 0.23569386368088177 0.027058292300859463 0.06679493921931082 1.2967782219829864e-07 6.887134291614226 -0.5916799939904734 down PDPAK(ub)SAPAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PDPAKSAPAPK 11 1 Q93079;Q5QNW6;Q5QNW6-2 Q93079 HIST1H2BH;HIST2H2BF Histone H2B type 1-H;Histone H2B type 2-F 1 7201020.0 2666400.0 3928700.0 605920.0 True False 2217229.741548419 3907535.3133141045 732615.0705424579 1.0 1.7623502157179471 0.3304191066961021 21.080326834261154 -6.762072644933347 1.604602111876393 1.4416793385890967 0.3246380125048535 0.6993690191562225 0.3207502182249616 0.27946440454279153 1.418601139001299 0.15768056975941316 0.3781698505966569 1.7295270350581232e-07 6.762072644933347 -1.1170413260842431 PEFLEDPSVLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PEFLEDPSVLTK 12 0 G5E972;P42167;P42167-2;P42167-3;P42166 G5E972;P42166 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 0 6931280.0 2736600.0 869680.0 3325000.0 False True 2649728.130939108 1216947.7593212875 2454082.7521381434 1.0 0.45927268730395404 0.9261639801772326 21.33741291229554 -10.233766119140704 8.00704167215489 1.000000225045345 0.6927183337405947 0.366100805742135 0.19060757214797874 7.656027737748304e-07 7.350014879173763e-08 0.18455512289850387 0.061518329382512546 5.837593919233959e-11 10.233766119140704 -0.30728189130475037 PEPAK(ub)SAPAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PEPAKSAPAPK 11 1 P57053;O60814;P62807;Q16778 P57053;P62807;Q16778 H2BFS;HIST1H2BK;HIST1H2BC;HIST2H2BE Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E 1 8166300.0 2619100.0 3941800.0 1605400.0 True False 3433665.4634004827 3353698.805016059 1439288.6080842013 1.0 0.9767109931830023 0.4191697250141608 21.71131805601323 -6.915679313004479 0.8561544468652459 1.0143194532845115 0.337625527060058 0.9928941702718994 0.02263224542286702 0.10078139710007247 0.11927976163857487 0.019066257597921146 0.054952852843707496 1.2142851587087754e-07 6.915679313004479 -0.6766939262244535 down PEPAK(ub)SAPAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PEPAKSAPAPK 11 1 P57053;O60814;P62807;Q16778 P57053;P62807;Q16778 H2BFS;HIST1H2BK;HIST1H2BC;HIST2H2BE Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E 1 16111000.0 6742200.0 6256900.0 3111900.0 True False 6528172.551493697 8755312.799302464 2296800.035001108 1.0 1.3411582996989226 0.3518289409301202 22.638247760195817 -6.813597388655765 1.3993405588727577 1.1851545028423625 0.3330568477652613 0.8690151414386496 0.14850353185400963 0.20193697946253486 0.7786303594273877 0.08342910474334864 0.1926952071246813 1.5360403043253892e-07 6.813597388655765 -0.8520976550771011 down PEPAK(ub)SAPAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PEPAKSAPAPK 11 1 P57053;O60814;P62807;Q16778 P57053;P62807;Q16778 H2BFS;HIST1H2BK;HIST1H2BC;HIST2H2BE Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E 1 7912200.0 2376200.0 1353600.0 4182400.0 True False 3604869.1234893347 1112039.504274929 3355746.8067889553 1.0 0.30848262896116735 0.930892826295108 21.781515452002374 -10.680005555713239 9.568278140963029 1.0003298712707427 0.6196877276281747 0.33235980369042284 0.2540978990288569 0.0017895137768922345 5.984721799815417e-05 0.24622962149635297 0.0820097442704214 2.08926940369905e-11 10.680005555713239 -0.380642143642568 PEPAK(ub)SAPAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PEPAKSAPAPK 11 1 P57053;O60814;P62807;Q16778 P57053;P62807;Q16778 H2BFS;HIST1H2BK;HIST1H2BC;HIST2H2BE Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E 1 7381000.0 2619100.0 3288400.0 1473500.0 True False 3587452.0485161752 3143107.614715382 1125489.6476850845 1.0 0.8761392688204486 0.3137295307265791 21.77452811753612 -6.941975656059192 0.6409210120985019 1.0061608932893829 0.1528246514669282 0.9984113820687627 0.01190259384470343 0.08687680715126508 0.05059136414171773 0.011767693007767888 0.047999929323495116 1.1429423994819987e-07 6.941975656059192 -0.8533362418224546 down PEPAK(ub)SAPAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PEPAKSAPAPK 11 1 P57053;O60814;P62807;Q16778 P57053;P62807;Q16778 H2BFS;HIST1H2BK;HIST1H2BC;HIST2H2BE Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E 1 16766600.0 6742200.0 8901000.0 1123400.0 True False 5606438.030103419 8853048.546289826 1358297.7459852737 1.0 1.5790861325415415 0.2422746383161606 22.418653035630093 -6.78894848484976 1.5003830995762617 1.3240806742773863 0.22842626475766162 0.7979896238521497 0.2460198219728722 0.2368948893761121 1.0535203753363962 0.12907002142077803 0.3024369019515601 1.625741586556816e-07 6.78894848484976 -1.0956544095197247 down PEPAK(ub)SAPAPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PEPAKSAPAPK 11 1 P57053;O60814;P62807;Q16778 P57053;P62807;Q16778 H2BFS;HIST1H2BK;HIST1H2BC;HIST2H2BE Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E 1 5356800.0 2376200.0 2061300.0 919300.0 True False 3076037.741904573 1946586.8429716756 751996.832814556 1.0 0.6328228085284865 0.24446931276888245 21.552641774094823 -7.479575451474503 0.33869049311963273 1.0631375461200272 2.0579147073035964e-10 0.9995203325906344 0.006756212274867149 0.12069180964230329 0.03590800010619571 0.01975737674226133 0.06399592929666119 3.314549799953257e-08 7.479575451474503 -1.0631375459142358 down PEPPSTSTLK(ub)QVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PEPPSTSTLKQVTK 14 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 8137200.0 1893500.0 1907400.0 4336300.0 True False 1833391.878949496 2669034.7669595946 3200492.9437884605 1.0 1.4557906564356053 1.7456676777810816 20.80608375748841 -8.92686588215966 0.10143305087337072 3.129103987362455e-05 2.6238293394332692 0.9999644584210625 0.0018297431752152887 0.4229049201404977 0.03170987899797287 0.45248478546736126 0.3352618653970607 1.1834069563627725e-09 8.92686588215966 2.623798048393396 PEPPSTSTLK(ub)QVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PEPPSTSTLKQVTK 14 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 6018400.0 1893500.0 3009500.0 1115400.0 True False 1574529.1462728493 2993287.226161021 1348624.9829730955 1.0 1.9010681594853853 0.8565258929410716 20.586489032922685 -6.678437023052619 1.9070781201020535 1.5708949348519263 0.8605113268351647 0.3171751492992352 0.3820218595012779 0.4419859916154207 3.106433786183527 0.16080405821191235 0.42501741244967745 2.0968288189333752e-07 6.678437023052619 -0.7103836080167616 PEPTK(ub)SAPAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PEPTKSAPAPK 11 1 P58876 P58876 HIST1H2BD Histone H2B type 1-D 1 28614700.0 10232000.0 12361600.0 6021100.0 True False 9907190.760713635 17297651.344892398 4443993.280871872 1.0 1.7459693431446972 0.44856240161381145 23.24004460048563 -6.7508064416756035 1.6471236609638973 1.43821588977608 0.44586372153589254 0.6523400461046966 0.31347227549684525 0.2986337327046201 1.5943548597510595 0.1503336984339241 0.36462335398384305 1.774980385897791e-07 6.7508064416756035 -0.9923521682401875 PEPTK(ub)SAPAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PEPTKSAPAPK 11 1 P58876 P58876 HIST1H2BD Histone H2B type 1-D 1 18962800.0 5620900.0 3115900.0 10226000.0 True False 8527316.242833592 2559843.3003621805 8204826.617784982 1.0 0.30019331140832123 0.9621815802457623 23.02366033051916 -10.931595751000518 10.293191808392793 1.0728966617067435 0.6311874458270417 0.2927145284686071 0.27025557906001746 0.1360742022737074 0.0009042910344678388 0.07875929887739976 0.08722461307659077 1.1705884885736526e-11 10.931595751000518 -0.4417092158797018 PEPTK(ub)SAPAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PEPTKSAPAPK 11 1 P58876 P58876 HIST1H2BD Histone H2B type 1-D 1 14947630.0 5038200.0 7257940.0 2651490.0 True False 6900958.692235571 6937260.212002006 2025262.671150677 1.0 1.0052603589421971 0.2934755533936679 22.718365366643717 -6.905235174326769 0.927583765248475 1.025494762075098 0.21028425233216563 0.9889955284927969 0.035069391770228754 0.10765355571729139 0.1564869204878192 0.028051826868240225 0.07510215438824915 1.243840878466837e-07 6.905235174326769 -0.8152105097429324 down PEPTK(ub)SAPAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PEPTKSAPAPK 11 1 P58876 P58876 HIST1H2BD Histone H2B type 1-D 1 30274100.0 10232000.0 17895700.0 2146400.0 True False 8508361.354456728 17799292.31208166 2595202.3161676973 1.0 2.091976535852969 0.30501787689216037 23.020449875919905 -6.7412916555825495 1.6817793190642285 1.648713316532937 0.30361195282475245 0.6109014469542078 0.4587880780305065 0.31543402127944603 1.7522305715692414 0.21576178486688238 0.5287496770878644 1.8142968411156046e-07 6.7412916555825495 -1.3451013637081846 PEPTK(ub)SAPAPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PEPTKSAPAPK 11 1 P58876 P58876 HIST1H2BD Histone H2B type 1-D 1 15442500.0 5620900.0 6288200.0 3533400.0 True False 7276365.854503576 5938256.142227948 2890357.455745622 1.0 0.8161019196901116 0.3972254163054057 22.79478665261161 -6.957424234537955 0.4703306284060416 1.0110282092744982 0.1851176559302949 0.9996624183952413 0.0046344530114797175 0.08063438545264674 0.024630695998194528 0.005795253524657083 0.0345713701944774 1.1030006426127857e-07 6.957424234537955 -0.8259105533442033 down PFGLVINLNYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PFGLVINLNYK 11 0 C9J3L8;C9J5W0;A0A3B3IRT8;E9PAL7;C9IZQ1;P43307;P43307-2;C9JY01;C9JBX5 C9J3L8 SSR1 Translocon-associated protein subunit alpha 0 12233900.0 4859800.0 7374100.0 0.0 False True 7372671.898970394 6058134.240893726 0.0 1.0 0.8217013212997794 0.0 22.813756124441092 -7.217900594459366 0.8778001141193842 0.9900701832970389 7.940714536892749e-16 0.9891681335550216 0.04532575523072962 0.09479106537506207 0.13948738230691665 0.03826938095409216 0.06724034965745222 6.054794469130998e-08 7.217900594459366 -0.9900701832970381 down PFGVALLFGGVDEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PFGVALLFGGVDEK 14 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 21081100.0 7059300.0 10118000.0 3903800.0 False True 9254810.662358439 8608433.839655092 3499872.2238938 1.0 0.9301577475450343 0.37816789036307674 23.141772044641993 -6.930322937131031 0.7441391761328751 1.0082943793513262 0.2639106456028303 0.9966012779850666 0.01621503424787246 0.09247057801166075 0.07686197510230076 0.014801123473096825 0.04985720343154646 1.1740242373390641e-07 6.930322937131031 -0.7443837337484959 down PFGVALLFGGVDEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PFGVALLFGGVDEK 14 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 82681000.0 35563000.0 24347000.0 22771000.0 False True 34434072.031202026 34068884.06792768 16806591.984642882 1.0 0.9893945751480269 0.4880802935364074 25.037333462367375 -6.911469118416568 0.885674075148886 1.0148097782028065 0.42121668831213943 0.9914641889370233 0.022068216533376407 0.10345444616323217 0.1335581532872942 0.018199821606473203 0.05076591383663299 1.2261140854532459e-07 6.911469118416568 -0.5935930898906671 down PFGVALLFGGVDEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PFGVALLFGGVDEK 14 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 228864000.0 70095000.0 93637000.0 65132000.0 False True 106339239.6309169 76926745.76077984 52258631.651630275 1.0 0.7234088378643464 0.4914331890373672 26.6640988148092 -6.991139411179781 0.1676407242197941 1.212798317453559 4.362377715474197e-08 0.9999977296970026 0.00031318205671067604 0.07348926627551526 0.005163723963864784 0.00995853849888429 0.026638650142202912 1.0206118084969117e-07 6.991139411179781 -1.2127982738297818 down PFGVALLFGGVDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PFGVALLFGGVDEK 14 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 39792300.0 7059300.0 11599000.0 21134000.0 False True 9669313.980409373 11086517.827236282 16142584.468392655 1.0 1.1465671556118926 1.6694653313666852 23.204982106164884 -6.947505669201516 0.5855976724103513 0.99387189293497 1.8482734182080556 0.9989906400507825 0.009128972389074454 0.08450326948290893 0.040230295226841045 0.00950783275002871 0.04374915268927947 1.1284812064423124e-07 6.947505669201516 0.8544015252730855 PFGVALLFGGVDEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PFGVALLFGGVDEK 14 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 63164000.0 35563000.0 13109000.0 14492000.0 False True 29572210.20802822 13038379.215067241 17522210.196562734 1.0 0.4408997204925725 0.5925228474064421 24.81773873780165 -10.51652167863751 9.486117103432829 1.0000125277962615 0.5167112839496029 0.9312540631225202 0.06189988235737262 1.6400853412946972e-05 8.358815144733952e-07 0.059935852876885555 0.019978101125191872 3.044236027381432e-11 10.51652167863751 -0.4833012438466586 PFGVALLFGGVDEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PFGVALLFGGVDEK 14 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 166736000.0 70095000.0 65650000.0 30991000.0 False True 90739359.27901728 61996519.78901196 25350955.99451314 1.0 0.6832373545682302 0.27938213577815435 26.43522513690165 -7.211561969719906 0.3503921742485434 1.0464411637654731 6.877141340525136e-14 0.9998226306707819 0.003927560598163902 0.09078191242990703 0.021043189723946802 0.009247955432189595 0.04296114826177222 6.143813590348384e-08 7.211561969719906 -1.0464411637654043 down PFGVSLLYIGWDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PFGVSLLYIGWDK 13 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0;H0YLC2;H0YMV3 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 39526000.0 11973000.0 16200000.0 11353000.0 False True 18163916.343547616 13308983.428822285 9109074.573803328 1.0 0.7327155210968611 0.5014928719950393 24.114571961568313 -6.972818325012403 0.17845963260061795 1.1824381353358449 0.04552714487306037 0.999996840386819 0.0003620228089256861 0.0753983303320732 0.005618309455123687 0.00902662649940973 0.026070942449440852 1.064588265907763e-07 6.972818325012403 -1.1369109904627845 PFGVSLLYIGWDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PFGVSLLYIGWDK 13 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0;H0YLC2;H0YMV3 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 29394500.0 11973000.0 10800000.0 6621500.0 False True 15499284.523114001 10198970.506036991 5416454.9423274025 1.0 0.658028471625727 0.34946483718328236 23.885698283660762 -7.404506607002999 0.24438068999739973 1.1318564392271024 5.257914382890959e-13 0.9999158099188178 0.002437896176755976 0.11883661506989204 0.019897850679337303 0.02152547156592942 0.056953456546496736 3.939974336426683e-08 7.404506607002999 -1.1318564392265766 down PFISSK(ub)FSQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PFISSKFSQK 10 1 J3KN59;Q12982;Q12982-2;H7C096 J3KN59 BNIP2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 1 9019400.0 3579300.0 2295500.0 3144600.0 True False 3465677.080709764 3212105.120874357 2320934.924022136 1.0 0.9268333563889121 0.6696916273419257 21.724705804964152 -6.947850107623724 0.5819747292776606 1.0030515320773064 0.5807117474823223 0.9990215319743493 0.004430830481242165 0.08436085022163993 0.03962606798048513 0.004632492950427396 0.021492177123654366 1.1275865641949887e-07 6.947850107623724 -0.422339784594984 PFLAILGGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PFLAILGGAK 10 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 30168500.0 7225500.0 10557000.0 12386000.0 False True 9472700.471841544 8981936.750863684 11104415.534901533 1.0 0.948191783067912 1.17225447673664 23.175344336301094 -6.845836086580777 1.254929977196084 0.9724213436832387 1.1805214322985713 0.9340345284992204 0.024599220815347884 0.16209912273448615 0.49333515529458105 0.015353223737072727 0.035448227945877514 1.4261457545229482e-07 6.845836086580777 0.20810008861533258 PFLAILGGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PFLAILGGAK 10 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 19084600.0 6656800.0 4427900.0 7999900.0 False True 6445483.5277481 6195983.561193462 5904486.19814434 1.0 0.9612907293175866 0.9160656718344338 22.619857160171456 -6.969077572761352 0.27934938289071415 1.0100416643410075 0.8659378745739057 0.9999742348374963 0.00017401123687434955 0.07660322666762437 0.01009744948101867 0.0008385037157010069 0.004154508345176551 1.0737975957565161e-07 6.969077572761352 -0.1441037897671018 PFLAILGGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PFLAILGGAK 10 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 15445000.0 7225500.0 8219500.0 0.0 False True 9896962.611795511 7856335.311748308 0.0 1.0 0.793812770635799 0.0 23.238554397823986 -7.260454289455766 0.8455215328227466 0.9891475908439518 4.750127932140829e-17 0.9887068289214681 0.045813078716869855 0.09957540604531741 0.13791440914456013 0.03886967213132453 0.06850916244110739 5.489663326001743e-08 7.260454289455766 -0.9891475908439518 down PFLAILGGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PFLAILGGAK 10 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 14854100.0 6656800.0 3072600.0 5124700.0 False True 5535424.146241945 3056047.2939366517 6196251.076064395 1.0 0.5520890925786478 1.1193814443778607 22.400262435605732 -6.696162170541751 1.844036727228942 0.720843114694618 1.117609423776377 0.3997034260605411 0.18920218572163888 0.40351594559960907 2.6647473366211223 0.08192954579941755 0.21174581567741063 2.0129724425016122e-07 6.696162170541751 0.3967663090817589 PFLAILGGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PFLAILGGAK 10 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 8055800.0 1989100.0 3935000.0 2131700.0 False True 2574929.161022801 3716013.7908570045 1743752.4730890768 1.0 1.4431518533041692 0.6772040565172022 21.29610131212609 -6.749846423910155 1.6503990386266765 1.2606330702930695 0.6757013434449363 0.6482603763200929 0.1862147438771787 0.3003416145569614 1.6095150644172769 0.08913208490243557 0.2164246992887072 1.7789083599860632e-07 6.749846423910155 -0.5849317268481332 PFLELDTNLPANR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PFLELDTNLPANR 13 0 P30046;B5MC82;P30046-2;A6NHG4 P30046 DDT;DDTL D-dopachrome decarboxylase;D-dopachrome decarboxylase-like protein 0 51861600.0 19235000.0 9731600.0 22895000.0 False True 18624395.453706674 13617478.629623592 16898112.66472261 1.0 0.7311635249300619 0.9073106671690385 24.150690260787968 -10.180735087335028 4.685940285688364 1.000026186776778 0.8192370964017556 0.5840484616814727 0.0719117696936168 1.9676350885564842e-05 3.4401400596809006e-06 0.06963835257959557 0.023209423867675657 6.5957610340065e-11 10.180735087335028 -0.18078909037502233 PFLELDTNLPANR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PFLELDTNLPANR 13 0 P30046;B5MC82;P30046-2;A6NHG4 P30046 DDT;DDTL D-dopachrome decarboxylase;D-dopachrome decarboxylase-like protein 0 44395000.0 19235000.0 13473000.0 11687000.0 False True 15994754.754981928 13400418.274818879 14130697.665417384 1.0 0.8378007965795796 0.8834582262673367 23.931095536222244 -10.807084661650208 11.352180466516502 1.0008998312815038 0.8606295114234582 0.9255059171320559 0.018639567617000863 0.00042700615545837974 7.256382397034248e-06 0.01815420191374875 0.0060158945800959495 1.559248512273567e-11 10.807084661650208 -0.1402703198580456 PFLNGLTGKPVMVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PFLNGLTGKPVMVK 14 1 P62306;A0A0B4J254;F8W0W6 P62306 SNRPF Small nuclear ribonucleoprotein F 0 19699600.0 5148000.0 7397600.0 7154000.0 False True 6749077.853302913 6293906.915618947 6413772.706013693 1.0 0.932558054955432 0.9503183761430273 22.68625896521366 -10.440008861932721 5.963580380913517 1.000026795429233 0.9414382166958295 0.9354696155717834 0.007250620762925011 2.58430987225958e-06 2.426757205559156e-07 0.007023594723500423 0.002340127788706208 3.6307064610938747e-11 10.440008861932721 -0.05858857873340351 PFLNGLTGKPVMVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PFLNGLTGKPVMVK 14 1 P62306;A0A0B4J254;F8W0W6 P62306 SNRPF Small nuclear ribonucleoprotein F 0 19066700.0 5995200.0 2839500.0 10232000.0 False True 5804885.65760656 3973327.1577968835 7551932.246579687 1.0 0.6844798316725407 1.300961412854678 22.46883621904574 -6.7676067105587645 1.5838157380817781 0.8184688498086363 1.304102024245969 0.7212251080237841 0.13289592759460678 0.2703302554817193 1.3379458098633674 0.06615601240844818 0.15781420473011118 1.7076280869682454e-07 6.7676067105587645 0.4856331744373328 PFLNGLTGKPVMVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PFLNGLTGKPVMVK 14 1 P62306;A0A0B4J254;F8W0W6 P62306 SNRPF Small nuclear ribonucleoprotein F 0 18535800.0 5148000.0 5197800.0 8190000.0 False True 7051354.719468994 4968144.009173952 6255690.678344653 1.0 0.7045658893682888 0.8871615352256369 22.749469026736552 -10.385237590673068 5.614730012268481 1.0000721426424302 0.7958637129447652 0.6249727870141946 0.07454436026741072 6.734319029063677e-05 7.37352614096626e-06 0.07220271127599466 0.02405908882244681 4.118721334343672e-11 10.385237590673068 -0.20420842969766495 PFLNGLTGKPVMVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PFLNGLTGKPVMVK 14 1 P62306;A0A0B4J254;F8W0W6 P62306 SNRPF Small nuclear ribonucleoprotein F 0 11647200.0 5995200.0 3454700.0 2197300.0 False True 4985274.432392389 3436088.8453957397 2656745.27083269 1.0 0.689247681746337 0.5329185598229427 22.249241494480017 -13.999999999712157 0.08889632415228385 2.5989960236872762 0.13420978920805074 0.9998475564998275 0.0023968519756025377 12.173705197065775 0.08635768304422412 3.692700963641228 0.3585954106378676 1.0000000006627822e-14 13.999999999712157 -2.4647862344792255 PFLWLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PFLWLAR 7 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 18669500.0 3100400.0 4683100.0 10886000.0 False True 4064654.4243163094 3984399.73458082 9759621.145885529 1.0 0.9802554703653586 2.4010949338029235 21.95470126934447 -6.903749456018308 0.9372546404785833 0.9468489193696128 2.562135665057979 0.9883412828547953 0.07182372603805807 0.10869792147278566 0.16226131416344935 0.05704319331525841 0.15141387505581375 1.2481033359542716e-07 6.903749456018308 1.6152867456883662 up PFLWLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PFLWLAR 7 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 9426300.0 3612900.0 1506400.0 4307000.0 False True 3498210.4671014734 2107913.375772221 3178867.492769619 1.0 0.6025690551199978 0.9087124753255759 21.73818565981566 -9.794398749973059 6.009080350918265 1.000000013914704 0.7556407652223245 0.45930361005461806 0.12498252793733267 2.3289912142198595e-08 4.801391049776221e-09 0.12101381952930618 0.040337937438775055 1.6054665077979756e-10 9.794398749973059 -0.24435924869237957 PFLWLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PFLWLAR 7 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 12300200.0 3100400.0 4043900.0 5155900.0 False True 4246701.665159611 3865227.1266109804 3938182.6090936703 1.0 0.9101715711093417 0.9273508994999429 22.01791133086736 -10.791878299514517 10.111696178753467 1.0006387043991616 0.9187612353053419 0.9675495651542408 0.007013431446780252 0.00010175671738912362 2.094381238104736e-06 0.006842624214389139 0.002263575266095603 1.6148110050122074e-11 10.791878299514517 -0.08187746909381965 PFSQFWQPLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PFSQFWQPLLR 11 0 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 0 5029210.0 892410.0 1824800.0 2312000.0 False True 1222358.0934734512 1744174.3021933583 1765953.2171346566 1.0 1.4268930778190496 1.4447102093597843 20.221235558243738 -11.700333379682176 0.503825966875496 2.9486957038409034e-13 1.4438007723747208 0.9998844734199082 0.0022095006233227143 5.010873829471535 0.24889734125115692 5.420467382438758 0.00360094824299068 1.9937312693265267e-12 11.700333379682176 1.443800772374426 PFSVDFFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PFSVDFFR 8 0 Q9NYH9;J3QSA7;J3KRR8 Q9NYH9 UTP6 U3 small nucleolar RNA-associated protein 6 homolog 0 3043620.0 874420.0 1047100.0 1122100.0 False True 1146373.0878953263 890876.7615638319 1005995.8559432435 1.0 0.7771263744505983 0.8775466439029834 20.128645215914325 -10.02843956145427 4.385823629113891 1.000008986336478 0.8273365091562996 0.7976454785325675 0.04099640342227591 18889899.40223854 1.0226711850241414 1805.5234142823317 0.014034159318442556 9.366135545515558e-11 10.02843956145427 -0.17267247718017842 PFSVDFFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PFSVDFFR 8 0 Q9NYH9;J3QSA7;J3KRR8 Q9NYH9 UTP6 U3 small nucleolar RNA-associated protein 6 homolog 0 3056730.0 874420.0 945010.0 1237300.0 False True 1197716.704311982 903256.3334698289 945075.222993387 1.0 0.7541485646964378 0.7890640746605244 20.191855277437217 -10.607889475408266 9.72179288054492 1.0000352100608945 0.7716063197151679 0.982774032596739 0.014254197253512353 1.0879890756644574e-05 4.388152451677935e-07 0.013803686372315074 0.004600522381367397 2.4666670050661938e-11 10.607889475408266 -0.22842889034572655 PFVPNVHAAEFVPSFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PFVPNVHAAEFVPSFLR 17 0 P15170-2;P15170-3;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 49705000.0 16519000.0 21869000.0 11317000.0 False True 21656568.97022354 18606230.44469433 10146025.400329474 1.0 0.8591495019491204 0.4684964370062331 24.368301360448207 -6.953200608307018 0.5225253915533407 1.0065110211431183 0.303625996943232 0.9994291148220583 0.005371952843058256 0.08222541399651259 0.030836102091111043 0.0060615601415288 0.03227649561564059 1.1137799400857659e-07 6.953200608307018 -0.7028850241998863 down PFVPNVHAAEFVPSFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PFVPNVHAAEFVPSFLR 17 0 P15170-2;P15170-3;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 350713900.0 128940000.0 99499000.0 122274900.0 False True 124846870.27818762 139229469.58043033 90247435.52162889 1.0 1.1152019211230122 0.7228650211297791 26.895584414640293 -6.828093635847709 1.336478735291781 1.0616413994727547 0.7127179365953396 0.9019944864187147 0.051546839802033145 0.18317537739165413 0.6405652776215148 0.0302893633883328 0.06970935553808376 1.4856153023998664e-07 6.828093635847709 -0.34892346287741516 PFVPNVHAAEFVPSFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PFVPNVHAAEFVPSFLR 17 0 P15170-2;P15170-3;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 52226000.0 14593000.0 26929000.0 10704000.0 False True 22138647.8912044 22123309.552762695 8588349.708270146 1.0 0.9993071691407224 0.38793469910519074 24.400063777016573 -6.907143729863117 0.9149617634348752 1.0206813970291495 0.31356718876683076 0.989798414623764 0.029125920946074798 0.10633736568795296 0.14923534185856943 0.023514012749942116 0.0636942148068735 1.23838667433647e-07 6.907143729863117 -0.7071142082623187 down PFVPNVHAAEFVPSFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PFVPNVHAAEFVPSFLR 17 0 P15170-2;P15170-3;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 123828000.0 16519000.0 23417000.0 83892000.0 False True 22626520.709189642 22382359.51033636 64078437.40997427 1.0 0.9892090701000213 2.8320057791275506 24.4315114219711 -6.905582275464707 0.9253085039016545 0.9346698860041848 3.048945181885607 0.9891445843381761 0.09024571586920578 0.10741192240462584 0.15515553088956 0.07230805096800286 0.19398828837165247 1.2428471607958267e-07 6.905582275464707 2.114275295881422 up PFVPNVHAAEFVPSFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PFVPNVHAAEFVPSFLR 17 0 P15170-2;P15170-3;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 291803600.0 128940000.0 64574000.0 98289600.0 False True 107219323.01052094 64226127.04506461 118841500.92023706 1.0 0.5990163455775821 1.1083963000640817 26.67598969007457 -6.696790975956604 1.842130051063909 0.750228915060965 1.1068021768751144 0.40243989188168405 0.16936131827912732 0.40223926935352383 2.6513614247154407 0.07340638549225706 0.18954614261525823 2.0100600129686405e-07 6.696790975956604 0.3565732618141494 PFVPNVHAAEFVPSFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PFVPNVHAAEFVPSFLR 17 0 P15170-2;P15170-3;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 33469300.0 14593000.0 9915100.0 8961200.0 False True 18890926.171035044 9363315.968926627 7330353.549676711 1.0 0.49565150401588837 0.38803568884389306 24.171190099109022 -13.999999999999998 0.21709924655571633 4.005327318007811 0.3288470023240915 0.9994951578042814 0.005993749731675849 12.922343943626943 0.1476295427602015 16.62428982773407 0.06071770983948793 1.0000000000000041e-14 13.999999999999998 -3.676480315683719 PGDGEFVEVISLPK(ub)NDLLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGDGEFVEVISLPKNDLLQR 20 1 A6NFX8;Q9UKK9;A6NJU6 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 1 51214000.0 21431000.0 13661000.0 16122000.0 True False 20750684.635736313 19115908.54117386 11899164.55036726 1.0 0.9212182092658725 0.5734347930802637 24.306655600877715 -6.942617509100515 0.6347546092089276 1.0037970359768102 0.4719592795842703 0.998486927699529 0.0072089235357111715 0.08659280288013375 0.04932409612890685 0.007165187860314378 0.029605177562902367 1.1412544682501251e-07 6.942617509100515 -0.5318377563925399 PGDGEFVEVISLPK(ub)NDLLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PGDGEFVEVISLPKNDLLQR 20 1 A6NFX8;Q9UKK9;A6NJU6 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 1 44265700.0 21431000.0 16478000.0 6356700.0 True False 17820826.05427699 16389229.743373068 7685856.57993999 1.0 0.9196672305456716 0.43128509063110393 24.08706087631199 -6.935556733884626 0.6996760649939541 1.0061230384178141 0.3151844110865746 0.9975221043451307 0.012509788279136486 0.08985334773470989 0.06428569561135672 0.01180070245818954 0.042920731875175235 1.1599606752546709e-07 6.935556733884626 -0.6909386273312396 down PGEVLGLVGTNGIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PGEVLGLVGTNGIGK 15 0 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 19087200.0 1730900.0 5863300.0 11493000.0 False True 2269226.662059442 4988518.494964395 10303814.608640682 1.0 2.198334163074328 4.540672283168677 21.113769289351232 -6.960490839650279 0.428460224239951 0.9054249064290945 5.923178451326205 0.9997879723682961 0.02141086667925917 0.07952625262856647 0.02048690034826586 0.03049958276178574 0.1945570837699115 1.0952396564488172e-07 6.960490839650279 5.0177535448971105 PGEVLGLVGTNGIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGEVLGLVGTNGIGK 15 0 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 8564900.0 2108500.0 1839700.0 4616700.0 False True 2041566.8216345494 2574301.8039087583 3407447.7719687647 1.0 1.2609441810225357 1.66903563276006 20.961245357883126 -6.96455477305796 0.3656159406149245 0.9670154957032171 1.9770720225500127 0.9999036672230598 0.002702297262164187 0.07811241041390928 0.015394854927982867 0.005417532366939663 0.03474264258239467 1.085038696327622e-07 6.96455477305796 1.0100565268467956 PGEVLGLVGTNGIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PGEVLGLVGTNGIGK 15 0 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 9468400.0 1730900.0 3703300.0 4034200.0 False True 2370860.5058136904 3539675.960824558 3081405.0469570197 1.0 1.4929920812062811 1.299699007765734 21.176979350874124 -10.157346915248645 4.490815962223228 0.9999360761423234 1.3963455444947435 0.8486227655754628 0.07891156682692806 55241153.79814764 4.703482204014794 37211.44216278111 0.027013528244049095 6.960702697356991e-11 10.157346915248645 0.3964094683524201 PGEVLGLVGTNGIGK(ub)STALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PGEVLGLVGTNGIGKSTALK 20 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 10955500.0 3089800.0 3933500.0 3932200.0 True False 4050757.7216657586 3346637.1326629096 3525333.6643258394 1.0 0.8261755855609899 0.870289932540361 21.949760368442814 -10.836655933026801 7.134756367077313 1.0103695024064574 0.8482327590507278 0.9404088654015554 0.018009606739257934 0.0030847126255647375 7.062172314483048e-05 0.018107623322534606 0.005812575581074241 1.4566126154339282e-11 10.836655933026801 -0.16213674335572958 PGEVLGLVGTNGIGK(ub)STALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGEVLGLVGTNGIGKSTALK 20 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 22184200.0 5645100.0 6635400.0 9903700.0 True False 5465899.390471512 9284949.823153883 7309623.865368573 1.0 1.6987048534665623 1.3373140160814436 22.382027474080342 -10.18345945361308 4.73207302435268 0.9999291415187895 1.5180094347768438 0.7325793808208168 0.1475371915616194 0.00011031162404406402 1.9035128748910218e-05 0.1428717277180189 0.0476174238206354 6.554514769140447e-11 10.18345945361308 0.5180802932580543 PGEVLGLVGTNGIGK(ub)STALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PGEVLGLVGTNGIGKSTALK 20 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 11288000.0 5645100.0 5642900.0 0.0 True False 4694150.7703326475 5612500.577672047 0.0 1.0 1.1956370496540998 0.0 22.16243274951462 -6.9174290260213525 1.2640493719293235 1.1028560994562504 2.5262602416644966e-21 0.9577711120736411 0.10760698569683907 0.12375971049786552 0.39589012616399855 0.06995506465805039 0.1369566191363933 1.2094028117860162e-07 6.9174290260213525 -1.1028560994562504 down PGFCFHLCSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PGFCFHLCSR 10 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 5929200.0 1415100.0 2384200.0 2129900.0 False True 1855209.8038478945 2028486.6535388085 1909518.379443467 1.0 1.0934001369179487 1.0292735492680831 20.82315091835635 -10.414799734864483 6.266855136903895 0.9999868071012977 1.0613368430930052 0.5495184638259787 0.02617956978133869 4.82684683598855e-06 4.5073013700201576e-07 0.025353710987641474 0.008449419814499981 3.8476916879417465e-11 10.414799734864483 0.06135003599170752 PGFCFHLCSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PGFCFHLCSR 10 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 16447500.0 5420100.0 3741000.0 7286400.0 False True 8222687.962387242 3073389.3214335875 5846239.846257431 1.0 0.3737694213245214 0.7109888971829753 22.971178651321253 -10.634711732387249 6.742634864640748 1.0015757974226318 0.5423791592538373 0.710599219040924 0.13766927453033376 0.0032704044626226626 0.00017717684378474132 0.1336765490755192 0.0444325672950366 2.3189333560916966e-11 10.634711732387249 -0.4591966381687945 PGFCFHLCSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PGFCFHLCSR 10 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 5043600.0 1415100.0 2059700.0 1568800.0 False True 1938300.711639585 1968695.6434829338 1198281.7504501932 1.0 1.015681226169307 0.618212511224113 20.886360979879242 -6.897715805570403 0.9756109870156311 1.0175768750450336 0.5783761711388327 0.9853947457640058 0.022210697746393972 0.11310568985841046 0.1870608812736412 0.017145514920749012 0.044119070717699174 1.2655642388399562e-07 6.897715805570403 -0.4392007039062009 PGFSIADK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PGFSIADK 8 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 34353900.0 9840900.0 13749000.0 10764000.0 False True 12901515.199411163 11697702.79318225 9650244.53557889 1.0 0.9066921685071645 0.747993114484672 23.621037175000172 -6.963085522680201 0.38951521937984 1.0097995162353288 0.6391879785388924 0.9998680762977306 0.0011948484153256572 0.0786167643133635 0.017189057920052618 0.0020495529598173806 0.013352233730082513 1.0887156787943142e-07 6.963085522680201 -0.3706115376964364 PGFSIADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGFSIADK 8 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 25313300.0 8256600.0 2300700.0 14756000.0 False True 7994498.752434345 3219381.507992001 10890960.929488849 1.0 0.40269960727827886 1.362306914635833 22.930576150240903 -6.738373255900286 1.6925608797140086 0.6439395337129636 1.362681208844089 0.5976357157881905 0.25097213007880137 0.3207779812179949 1.8037169334773557 0.11733181461718614 0.2884476268367451 1.8265297240441664e-07 6.738373255900286 0.7187416751311253 PGFSIADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PGFSIADK 8 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 30471300.0 9840900.0 9744400.0 10886000.0 False True 13479346.670322932 9313860.187578341 8314951.004207551 1.0 0.6909726721462238 0.6168660253033128 23.684247236523063 -13.999999999999998 0.2005782660945289 2.7216303426973445 0.5690110778463251 0.9994869625484707 0.0037582620201924272 12.542366983509456 0.14200639796008974 8.473484761306958 0.04698448972780659 1.0000000000000041e-14 13.999999999999998 -2.1526192648510194 PGFSIADK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PGFSIADK 8 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 15891700.0 8256600.0 4957200.0 2677900.0 False True 6865728.729398694 4930494.579672845 3237836.508789361 1.0 0.7181312827814946 0.4715940050070888 22.71098142567518 -6.975537947808169 0.18284377853022007 1.1837365354111318 6.957769469486127e-10 0.9999965066959098 0.00040344952739385966 0.0750978782746894 0.00577178595683835 0.009248874986756923 0.027337795676194532 1.0579424709994991e-07 6.975537947808169 -1.1837365347153548 down PGFSIADK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 PGFSIADKK 9 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 15745300.0 7610300.0 6727800.0 1407200.0 True False 9977176.998250028 5724038.464759005 1261596.4428155522 1.0 0.5737132322863459 0.12644823711525144 23.250200237917564 -7.724490331363398 0.4382440688305961 1.0340814330298918 3.2798598796182004e-21 0.9973697966855581 0.01829150322635913 0.11637462238998922 0.07631139551513302 0.02927207838835687 0.0762988106190562 1.885860953678638e-08 7.724490331363398 -1.0340814330298918 down PGFSIADK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGFSIADKK 9 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 33451800.0 13917000.0 14011000.0 5523800.0 True False 13475212.452780653 19605665.366399758 4076951.0695520756 1.0 1.4549429506288836 0.30255189547759476 23.683804683174984 -6.799590978320369 1.457489093718863 1.2511404263600805 0.2867863431754127 0.8309992033456369 0.19482763135833608 0.22133608068814006 0.9282762835525213 0.10516071155883558 0.24463638117130113 1.5863865594377535e-07 6.799590978320369 -0.9643540831846678 down PGFSIADK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 PGFSIADKK 9 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 28915700.0 7569100.0 6681600.0 14665000.0 True False 11482878.075331684 5489216.276420921 11766456.32210217 1.0 0.4780348829282823 1.0246957465637199 23.452980949484004 -10.984611057872895 12.9019715633402 1.157403367287361 0.751365314744737 0.21619054477851818 0.22317336304266633 0.07276483485586564 8.679084013674706e-05 0.015560928912065876 0.07202889319844567 1.0360696266175824e-11 10.984611057872895 -0.40603805254262393 PGFSIADK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PGFSIADKK 9 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 15331400.0 7610300.0 4784400.0 2936700.0 True False 10424033.57062449 4573009.388104941 2243111.943235008 1.0 0.43869864358379823 0.2151865617121786 23.313410299440456 -11.121841615271277 0.17758723687883185 2.050373469479943 4.763418825651091e-12 0.9994918276094562 0.007442303232509614 3.368402286419309 0.10268446830047198 1.5872901968590727 0.16342725259711857 7.553676557288736e-12 11.121841615271277 -2.0503734694751796 PGFSIADK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PGFSIADKK 9 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 40475400.0 13917000.0 23426000.0 3132400.0 True False 11572602.127636265 23299799.48830309 3787370.357418798 1.0 2.013358727045612 0.32727041988026756 23.46420995860926 -6.743934748291279 1.6720616208554548 1.60017246708345 0.3253633643756384 0.6225666407877584 0.42575434793651845 0.3107447412815575 1.7072340500043133 0.2013081022133422 0.4919183190441565 1.8032886603211453e-07 6.743934748291279 -1.2748091027078117 PGFSIADK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PGFSIADKK 9 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 47440900.0 7569100.0 8683800.0 31188000.0 True False 9798349.159266865 8200538.896326303 25512104.0159038 1.0 0.8369306668940838 2.603714523867067 23.224107271576454 -6.884323727543799 1.0553567527382943 0.8917540571190045 2.7398064573211993 0.977010345970488 0.12087698677655657 0.12387053897103643 0.24970846500138724 0.08785595132741592 0.21500182786586397 1.3051976177951692e-07 6.884323727543799 1.848052400202195 up PGFSIADK(ub)K(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGFSIADKKR 10 2 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 2 41440200.0 16822000.0 18248000.0 6370200.0 True False 16287994.817897245 25534521.562062882 4701653.518096354 1.0 1.5676896909376197 0.2886576015440635 23.95730567173759 -6.786018767810753 1.511992965583556 1.3189197123806362 0.2764599784748281 0.7882738258977762 0.24077103119049634 0.24131354983842887 1.0898412518863045 0.12536752524102393 0.2944159806219318 1.6367457887792524e-07 6.786018767810753 -1.0424597339058082 down PGFSIADK(ub)K(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PGFSIADKKR 10 2 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 2 47126500.0 16822000.0 27360000.0 2944500.0 True False 13988238.340956895 27212606.24946522 3560181.336170233 1.0 1.9453919490196279 0.254512487519332 23.737710947171866 -6.754938049636914 1.6312701580782103 1.552557417383007 0.24976866352532787 0.6701173038752437 0.3973984272183483 0.29147837436583623 1.527402015702871 0.1923177659391156 0.46455605501801595 1.7581743925857046e-07 6.754938049636914 -1.3027887538576792 PGGDTIFGK(ub)IIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGGDTIFGKIIR 12 1 P49773;D6REP8;D6RE99;D6RD60;D6RC06 P49773 HINT1 Histidine triad nucleotide-binding protein 1 1 5422500.0 1213900.0 1394400.0 2814200.0 True False 1175365.4089552672 1951191.1916999388 2077076.5958096716 1.0 1.660071988535268 1.767175195036493 20.164677914823166 -11.317656143683513 0.32094385280451204 1.3088886329058697e-13 1.7916263890332658 0.9993835960713532 0.008422351118778886 3.4912580420733517 0.16647023004801556 2.5033629687334376 0.03544570381374632 4.8122020781101494e-12 11.317656143683513 1.791626389033135 PGGFDISLFYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PGGFDISLFYR 11 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 56606000.0 0.0 35246000.0 21360000.0 False True 0.0 28956075.921745103 17138186.6375794 0.0 PGGFDISLFYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PGGFDISLFYR 11 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 47756000.0 0.0 31256000.0 16500000.0 False True 0.0 29516576.12376786 13497169.304296946 0.0 PGGLLLGDVAPNFEANTTVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PGGLLLGDVAPNFEANTTVGR 21 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 25089400.0 7115600.0 10502000.0 7471800.0 False True 9328620.50756843 8935142.536475362 6698689.810566553 1.0 0.9578203475236414 0.7180793564420184 23.153232324138123 -6.9369912797177005 0.6869825025985982 1.0028818834442024 0.6587760477251744 0.9977426760486365 0.005898846795781987 0.08916645692492464 0.06106340130133307 0.005618751962801323 0.02092217111521649 1.1561354562248763e-07 6.9369912797177005 -0.344105835719028 PGGLLLGDVAPNFEANTTVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGGLLLGDVAPNFEANTTVGR 21 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 75868000.0 27105000.0 23115000.0 25648000.0 False True 26244566.61152686 32344940.043132573 18930019.376492955 1.0 1.232443290906788 0.721292892989847 24.64551543807711 -6.783053929294472 1.5237758618013197 1.131094316476937 0.7168356190046771 0.7780967238875198 0.0984344404856794 0.24586606862590674 1.1277171598969749 0.05086760084035634 0.11973338065047719 1.6479577407178116e-07 6.783053929294472 -0.41425869747225985 PGGLLLGDVAPNFEANTTVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PGGLLLGDVAPNFEANTTVGR 21 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 278232000.0 45872000.0 163080000.0 69280000.0 False True 69591177.69240916 133977099.85014437 55586777.63349725 1.0 1.9252023646203975 0.7987618470718958 26.052401086576406 -6.68845992276634 1.8720050407700317 1.580876443262985 0.8027358322413461 0.3632145576530086 0.3914180144836102 0.41996428085450355 2.85222836255474 0.16734965002887447 0.4366192063420865 2.0489911246767084e-07 6.68845992276634 -0.7781406110216388 PGGLLLGDVAPNFEANTTVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PGGLLLGDVAPNFEANTTVGR 21 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 28300600.0 7115600.0 10646000.0 10539000.0 False True 9746429.611859681 10175624.518385833 8049905.257518215 1.0 1.0440361161592855 0.8259337601661745 23.216442385661015 -6.8541579244264526 1.2148206428500072 1.0236118396113307 0.8164879641910264 0.9461443255265604 0.02185317849432575 0.1529425073043371 0.4322532871516196 0.014059510547785873 0.032633905796012316 1.399078476956602e-07 6.8541579244264526 -0.2071238754203043 PGGLLLGDVAPNFEANTTVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PGGLLLGDVAPNFEANTTVGR 21 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 53884000.0 27105000.0 15321000.0 11458000.0 False True 22539008.4550967 15238462.732019618 13853814.82419376 1.0 0.6760928619543499 0.6146594625843457 24.425920713511385 -13.999999999999998 0.23377305499049075 3.0810829523713723 0.5858424860916123 0.9995151715798659 0.0037221040722313177 13.41166990573209 0.15306427413091125 12.982865734099507 0.031157506647842257 1.0000000000000041e-14 13.999999999999998 -2.49524046627976 PGGLLLGDVAPNFEANTTVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PGGLLLGDVAPNFEANTTVGR 21 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 142596000.0 45872000.0 53631000.0 43093000.0 False True 59382208.27230304 50646387.704562075 35250516.17151924 1.0 0.8528882501694449 0.5936208368990672 25.823527408668856 -6.962440793674551 0.39954852738257135 1.0143234222512438 0.4227257153980668 0.9998502871168595 0.0020555505668833378 0.07884046964968684 0.01799222824418557 0.0033362022167712987 0.02172603070830522 1.0903331247542543e-07 6.962440793674551 -0.591597706853177 PGHLQEGFGCVVTNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PGHLQEGFGCVVTNR 15 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 47076600.0 8232600.0 16784000.0 22060000.0 False True 10793018.324611807 14279892.623519586 19777442.814462144 1.0 1.3230675788770323 1.8324292815627625 23.363595042754792 -6.96441603806889 0.36794038769212706 0.9599035901626028 2.213266065830066 0.999900592246639 0.003416461595737204 0.07815972432190377 0.015562323926936449 0.006735535561060099 0.043308174026519076 1.0853853663506111e-07 6.96441603806889 1.2533624756674628 PGHLQEGFGCVVTNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGHLQEGFGCVVTNR 15 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 17182800.0 7688100.0 1702500.0 7792200.0 False True 7444045.473753167 2382317.12842021 5751189.059010773 1.0 0.3200298999811301 0.772589189478865 22.827655437799933 -10.557866650358674 5.604090248310029 1.0015100956255385 0.5463095447304845 0.5726508435385816 0.18475655627099163 0.003496139112669016 0.0002758263993610936 0.1794167550138514 0.05962992212834857 2.767791362235417e-11 10.557866650358674 -0.45520055089505396 PGHLQEGFGCVVTNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PGHLQEGFGCVVTNR 15 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 44029600.0 8232600.0 14170000.0 21627000.0 False True 11276414.697649661 13543922.546076195 16519148.022046344 1.0 1.2010841131001637 1.4649290989173558 23.426805104277683 -6.967385650007749 0.3144277450847049 0.961420392670515 1.713033801931589 0.9999542134949685 0.0012882213052657456 0.07716046991993258 0.012052304299635845 0.004093703716005379 0.02332608312216562 1.077989051481238e-07 6.967385650007749 0.7516134092610739 PGIVELPTLEELK(ub)VDEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGIVELPTLEELKVDEVK 18 1 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 9951000.0 2714300.0 2721700.0 4515000.0 True False 2628136.0322327027 3808489.003478003 3332386.052903367 1.0 1.449121718498926 1.2679655893125048 21.325608520763872 -10.3030537882494 4.97944284768194 0.9998786224936848 1.3585436539058593 0.8393047834923566 0.07395668004790575 9.968832789527796e-05 1.395285224697757e-05 0.0716323473652374 0.023869415847122818 4.976754430522291e-11 10.3030537882494 0.35866503141217454 PGIVELPTLEELK(ub)VDEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PGIVELPTLEELKVDEVK 18 1 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 47597400.0 5391400.0 14650000.0 27556000.0 True False 8179147.964136191 12035593.039027568 22109544.52177614 1.0 1.4714971647170416 2.703159866861652 22.963519132303112 -6.954513791501867 0.5068747800833758 0.9767368813249742 3.2516679893441554 0.9995095487567258 0.015901505844834473 0.08172229229404199 0.028841222144594388 0.018415801306538426 0.10163252943741523 1.1104172722444557e-07 6.954513791501867 2.274931108019181 PGIVELPTLEELK(ub)VDEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PGIVELPTLEELKVDEVK 18 1 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 10268700.0 2714300.0 4182100.0 3372300.0 True False 2257060.713878215 4159570.1972181494 4077432.3382465155 1.0 1.842914624157775 1.8065231090928124 21.106013796198148 -10.241721725732308 4.741375372094941 0.9997905771840256 1.8247188666275986 0.9985418036916238 0.014856773820576728 10486710.307138603 8.77094728546208 23976.39387528284 0.0050858688446111374 5.73163167755017e-11 10.241721725732308 0.824928289443573 PGIVELPTLEELK(ub)VDEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PGIVELPTLEELKVDEVK 18 1 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 43708100.0 5391400.0 5899700.0 32417000.0 True False 6979273.580382262 5571376.508746894 26517438.626508713 1.0 0.7982745545907864 3.799455390464336 22.73464545439556 -6.890819475140168 1.0175601339217841 0.8418959402710853 4.061730828831042 0.9814163060472606 0.18672042541214534 0.11847928298973133 0.21800251099203086 0.13966814749560172 0.3492253719467219 1.2858210310537594e-07 6.890819475140168 3.219834888559957 up PGLGLPPGAPPLVVPSAPPQEEAEAEAAAGGPHFLDPVFLSTK(ub)SHSQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PGLGLPPGAPPLVVPSAPPQEEAEAEAAAGGPHFLDPVFLSTKSHSQR 48 1 Q8N5I2 Q8N5I2 ARRDC1 Arrestin domain-containing protein 1 1 38541800.0 25060000.0 11253000.0 2228800.0 True False 20838500.346235894 11192377.855454382 2694831.775193147 1.0 0.5371009271056344 0.12931985173683194 24.31274812124749 -7.898316271497984 0.40222775399510313 1.0544836522811567 9.833326619050822e-19 0.9976592490302922 0.01720879556221675 0.10589823878799173 0.08020829020476945 0.039760038964511045 0.08086481205876055 1.263815648584216e-08 7.898316271497984 -1.0544836522811567 down PGLGLPPGAPPLVVPSAPPQEEAEAEAAAGGPHFLDPVFLSTK(ub)SHSQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PGLGLPPGAPPLVVPSAPPQEEAEAEAAAGGPHFLDPVFLSTKSHSQR 48 1 Q8N5I2 Q8N5I2 ARRDC1 Arrestin domain-containing protein 1 1 84192200.0 52383000.0 23608000.0 8201200.0 True False 67810826.12330069 22294194.046900135 6708665.751418193 1.0 0.3287704238606755 0.09893207522969563 26.015012284882108 -10.004668270527501 0.2713866674351156 1.5363114845818566 8.738575409981393e-12 0.9989487267886912 0.012395059405912597 1.470208157137921 0.12456321525878133 0.6942661547469284 0.09173407417814201 9.893084749007411e-11 10.004668270527501 -1.536311484573118 PGLVVVHAEDGTTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PGLVVVHAEDGTTSK 15 0 P30049;A0A087WTL3 P30049 ATP5D ATP synthase subunit delta, mitochondrial 0 6196000.0 1706800.0 1344400.0 3144800.0 False True 2237631.328674712 1143820.7604301546 2819406.263051701 1.0 0.5111748060426059 1.2599958835585119 21.09354092730671 -6.730539112611424 1.7210938994617635 0.7060078185496809 1.2596088762826128 0.5618429420983155 0.2054818897281761 0.3352264163676178 1.9455840443024897 0.09459921180532066 0.23461366395160776 1.859777063942052e-07 6.730539112611424 0.5536010577329319 PGMVVTFAPVNVTTEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGMVVTFAPVNVTTEVK 17 0 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 12471800.0 4810600.0 2591400.0 5069800.0 False True 4657890.136189309 3626159.5339724743 3741867.2892601374 1.0 0.7784982959986881 0.8033395335342572 22.151245180997453 -9.979581653334268 5.787632146271144 1.0000002597220015 0.7909189148621701 0.9895237801503924 0.010141392757200798 3.397909730172219e-08 5.991724715047065e-09 0.00981937345830845 0.003273120437955456 1.0481377107526339e-10 9.979581653334268 -0.20908134485983132 PGMVVTFAPVNVTTEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PGMVVTFAPVNVTTEVK 17 0 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 10147700.0 4810600.0 1867100.0 3470000.0 False True 4000227.0457143798 1857041.5617096676 4195560.956532756 1.0 0.4642340398401132 1.0488307060039619 21.93165045643173 -6.665645351912136 1.9526290247907305 0.6567562068015852 1.0464381237014422 0.25998810626302593 0.22781152697606696 0.47118902265124213 3.4591510711260134 0.09406288951839963 0.25276482676164375 2.15950715884456e-07 6.665645351912136 0.389681916899857 PGPALWPLPLSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PGPALWPLPLSVK 13 0 P07686 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 5533400.0 1221400.0 2434200.0 1877800.0 False True 1601267.2280544268 2071026.8484372853 1683503.2691295084 1.0 1.2933674106061774 1.0513568501461183 20.61078266194885 -10.353258585409236 5.184217310829365 0.9999235170731426 1.1723621303759835 0.4034560611417177 0.09880039758206494 8.738350460313639e-05 1.0901394574685386e-05 0.0957054464713452 0.03188769120282768 4.43344591349487e-11 10.353258585409236 0.17243861330284083 PGPALWPLPLSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGPALWPLPLSVK 13 0 P07686 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 6766900.0 2119700.0 1277100.0 3370100.0 False True 2052411.2837651158 1787052.6899885202 2487369.7091671415 1.0 0.8707088604142735 1.2119255671816915 20.968888431649646 -6.804010185926062 1.4392851824372808 0.929023836452968 1.2171270615328573 0.8436948830878693 0.05560904790337622 0.21507336494908763 0.8790951607460064 0.0303883386591227 0.07051300810861287 1.5703259735367008e-07 6.804010185926062 0.2881032250798893 PGPALWPLPLSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PGPALWPLPLSVK 13 0 P07686 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 7419900.0 1221400.0 2334100.0 3864400.0 False True 1672984.5870939083 2230971.74416348 2951708.3098162436 1.0 1.3335279723280862 1.7643368221004165 20.67399272347174 -6.967622771387728 0.30975162892084546 0.9334353624757907 2.1781186683131977 0.999957453309188 0.00204084336526541 0.07708186421187012 0.011777235984205074 0.006823923942050019 0.03825682467098463 1.0774006385652363e-07 6.967622771387728 1.244683305837407 PGPALWPLPLSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PGPALWPLPLSVK 13 0 P07686 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 3936920.0 2119700.0 831190.0 986030.0 False True 1762624.4686319295 826712.214491703 1192204.3141123909 1.0 0.46902345292719105 0.6763802133291198 20.749293707083922 -10.180171663634239 5.378707772886491 1.0000166384928506 0.5727018331280631 0.8498933198275244 0.08465304295053973 1.6890891146837102e-05 2.57455588740127e-06 0.08196814435242139 0.027321652129387773 6.604323472317461e-11 10.180171663634239 -0.4273148053647875 PGPMGPLGIPGSSGFPGNPGMKGEAGPTGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PGPMGPLGIPGSSGFPGNPGMKGEAGPTGAR 31 1 P05997 P05997 COL5A2 Collagen alpha-2(V) chain 0 21436300.0 2318500.0 7985800.0 11132000.0 False True 3039575.952385937 6794349.768404597 9980167.42568415 1.0 2.235295276326727 3.28340781149099 21.535438638367484 -6.973029584461596 0.17096902758048063 0.0859662439809763 5.460831349118888 0.9999973960405466 0.0015059398823707105 0.0753313091384525 0.005338477390925252 0.043779275405705 0.12104191805563903 1.0640705304831647e-07 6.973029584461596 5.374865105137912 PGPMGPLGIPGSSGFPGNPGMKGEAGPTGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGPMGPLGIPGSSGFPGNPGMKGEAGPTGAR 31 1 P05997 P05997 COL5A2 Collagen alpha-2(V) chain 0 28633800.0 2021900.0 2849900.0 23762000.0 False True 1957715.891232103 3987879.932032167 17538019.355280142 1.0 2.0370064675331236 8.958408844626817 20.900739981839497 -6.933624890309131 0.7164130990336515 0.9075760409946905 10.520056872586482 0.9972039183685962 0.18680019016284985 0.09079898057690558 0.06877662633447475 0.1740140406132765 0.6142642131026937 1.1651319450055844e-07 6.933624890309131 9.61248083159179 PGPMGPLGIPGSSGFPGNPGMKGEAGPTGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PGPMGPLGIPGSSGFPGNPGMKGEAGPTGAR 31 1 P05997 P05997 COL5A2 Collagen alpha-2(V) chain 0 23174200.0 2318500.0 7105700.0 13750000.0 False True 3175712.1051066164 6791746.678592357 10502533.19013905 1.0 2.1386531441786163 3.3071427265874447 21.598648699890376 -6.9708016573453575 0.23826185553624254 0.5712797646388789 4.908240505348668 0.9999879778319148 0.003265890813412578 0.07604342249709914 0.008093591586927693 0.028278324460801536 0.11427154717620135 1.069543228990268e-07 6.9708016573453575 4.336960740709789 PGPMGPLGIPGSSGFPGNPGMKGEAGPTGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PGPMGPLGIPGSSGFPGNPGMKGEAGPTGAR 31 1 P05997 P05997 COL5A2 Collagen alpha-2(V) chain 0 13292800.0 2021900.0 7819400.0 3451500.0 False True 1681299.4353573145 7777275.34017063 4173192.692067099 1.0 4.625752662860903 2.4821234125854565 20.681145257273773 -9.880256652980831 8.420350802424073 1.000000011816064 3.55393803772318 0.6542909166476193 0.8751329768132837 1.27794330478886e-08 5.9980435626051076e-09 0.8473438738550995 0.2824479537428974 1.3174779246795326e-10 9.880256652980831 2.553938025907116 PGPMGPLGIPGSSGFPGNPGMKGEAGPTGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PGPMGPLGIPGSSGFPGNPGMKGEAGPTGAR 31 1 P05997 P05997 COL5A2 Collagen alpha-2(V) chain 0 66137900.0 8406100.0 4014800.0 53717000.0 False True 10881862.159003474 3791372.8507071626 43941057.18296473 1.0 0.34841213712399793 4.0380089860455195 23.375422123160128 -6.861292452858273 1.1792714595842468 0.64522533780081 4.221067686237545 0.9551876372818756 0.34036871651263373 0.1454711948663147 0.3836970288239001 0.22500382647891834 0.525983986210676 1.3762823715416977e-07 6.861292452858273 3.5758423484367348 up PGPWRPLVKPGGWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PGPWRPLVKPGGWR 14 2 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 17229100.0 2632300.0 4521800.0 10075000.0 False True 3450970.7912294623 3847165.0658383486 9032535.64622421 1.0 1.114806614885238 2.617389770200352 21.718570832281394 -6.922180471558125 0.8083952925149136 0.969379699307383 2.872274886474411 0.9947654149581667 0.0533133524814022 0.09690561925688744 0.09909174158032569 0.04647349981163659 0.14224823301314232 1.1962433277536716e-07 6.922180471558125 1.902895187167028 up PGPWRPLVKPGGWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGPWRPLVKPGGWR 14 2 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 11587500.0 2995400.0 1940400.0 6651700.0 False True 2900312.666599062 2715211.839052324 4909420.223277376 1.0 0.936179009360467 1.692721022742081 21.46777700688738 -6.886402151003127 1.0434089589235185 0.9557754613609474 1.7533878626021353 0.9784946209081391 0.05023936666611138 0.12211179348257596 0.2392772564799693 0.036848774871757764 0.09075364060059396 1.298966195274165e-07 6.886402151003127 0.7976124012411879 PGPWRPLVKPGGWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PGPWRPLVKPGGWR 14 2 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 10055600.0 2632300.0 3790400.0 3632900.0 False True 3605532.4452327597 3622927.5948233777 2774883.8419240876 1.0 1.0048245716422877 0.7696183251916213 21.781780893804285 -6.902217514947881 0.9471340283137089 1.0091929565251956 0.7437860405544373 0.9876378450589696 0.012203444620408678 0.10979166198247246 0.16835349001510633 0.009621636970931375 0.025324445134752564 1.2525137004961303e-07 6.902217514947881 -0.2654069159707583 PGPWRPLVKPGGWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PGPWRPLVKPGGWR 14 2 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 9518300.0 2995400.0 3826700.0 2696200.0 False True 2490807.81871967 3806084.8075595223 3259962.9541797177 1.0 1.5280523768051817 1.308797463087863 21.248182282321658 -10.095485216376616 4.483889855863059 0.9999647371223148 1.4184249199367767 0.8292338213969697 0.08951044377396003 10261408.205201874 23103578.80252685 2128.129782604369 0.03064180860925089 8.026288823368675e-11 10.095485216376616 0.41846018281446185 PGQFIHTNWTGHGGTVSSSSYNA ddPTM_RPMI8226_Bortezomib_1h_R1 1 PGQFIHTNWTGHGGTVSSSSYNA 23 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 257397000.0 76894000.0 94656000.0 85847000.0 False True 100808778.64255516 80533693.76619816 76964375.94257168 1.0 0.798875800804533 0.7634689853298365 26.587046036355584 -13.999999999999998 0.24433947605511236 2.359796086480256 0.7484457282868259 0.9995323764203534 0.002252501014785317 13.78058543092613 0.15642975056873754 9.166489536504981 0.01687068161937013 1.0000000000000041e-14 13.999999999999998 -1.6113503581934303 PGQFIHTNWTGHGGTVSSSSYNA ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGQFIHTNWTGHGGTVSSSSYNA 23 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 223172000.0 49026000.0 28946000.0 145200000.0 False True 47469696.46547567 40504288.75139588 107167764.09337087 1.0 0.8532662259775418 2.257603736129072 25.500503489012523 -6.881101146617868 1.073692690219842 0.9076754491744166 2.359232341572481 0.9745605640252972 0.10052785316689711 0.12665670215496344 0.2664590947747682 0.07205373745832508 0.17473421704946365 1.3149185537131468e-07 6.881101146617868 1.4515568923980644 up PGQFIHTNWTGHGGTVSSSSYNA ddPTM_RPMI8226_Bortezomib_8h_R1 1 PGQFIHTNWTGHGGTVSSSSYNA 23 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 187947000.0 38635000.0 95179000.0 54133000.0 False True 58612119.59683973 78193563.8130788 43433588.82266328 1.0 1.3340852429656012 0.7410342625623991 25.80469567483865 -6.753854045360533 1.6355702141574395 1.1955291457964126 0.7394980946928476 0.665413771825659 0.14041990202592494 0.29335819014355746 1.5451174809031183 0.06778861693260185 0.1639128127844861 1.76256829846149e-07 6.753854045360533 -0.456031051103565 PGQFIHTNWTGHGGTVSSSSYNA ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PGQFIHTNWTGHGGTVSSSSYNA 23 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 278476000.0 76894000.0 90562000.0 111020000.0 False True 105323789.78221612 86560671.39151408 84799362.52867189 1.0 0.8218529884891193 0.8051301866749788 26.650256097878476 -13.999999999999998 0.33467175324800474 2.9947732671647826 0.8023281456112725 0.9997244510583349 0.0014638397182730194 19.226038856829312 0.1852567656786265 27.05970293479244 0.005267253251822895 1.0000000000000041e-14 13.999999999999998 -2.19244512155351 PGQFIHTNWTGHGGTVSSSSYNA ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PGQFIHTNWTGHGGTVSSSSYNA 23 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 151114000.0 49026000.0 53665000.0 48423000.0 False True 40767291.22005433 53375895.993331484 58548025.41734467 1.0 1.3092823780029492 1.436151965587147 25.2809087644468 -12.559149179533376 0.1390286559922377 3.1357755277395237e-18 1.6077558733753134 0.9996362921755698 0.003493361891191951 6.9849639930013945 0.10290715796301902 2.0967509127145476 0.13972154890895952 2.759629764518494e-13 12.559149179533376 1.6077558733753134 PGQFIHTNWTGHGGTVSSSSYNA ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PGQFIHTNWTGHGGTVSSSSYNA 23 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 152168000.0 38635000.0 72662000.0 40871000.0 False True 50013769.109705955 68618295.82496855 33432897.371873934 1.0 1.3719880954073524 0.6684738616387493 25.5758219969311 -6.763036740743092 1.6009741858494404 1.2152518242595776 0.6655040792820217 0.7032778940052533 0.15653502037525144 0.27783896346384895 1.4041786544093744 0.07711992345847653 0.18478474207747614 1.7256918945456458e-07 6.763036740743092 -0.5497477449775559 PGQVFIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGQVFIVK 8 0 Q9BX84-7;Q9BX84-6;Q9BX84-5;Q9BX84-4;Q9BX84-3;Q9BX84-2;Q9BX84 Q9BX84-7 TRPM6 Transient receptor potential cation channel subfamily M member 6 0 6430740.0 2011700.0 771340.0 3647700.0 False True 1947839.684648906 1079340.0844849616 2692257.941345655 1.0 0.554121621502701 1.3821763477577615 20.893443511795944 -6.760460157997198 1.6106835610001666 0.7411478729444534 1.3852727286067912 0.6928028381219891 0.18755125085285582 0.2821772638378959 1.4429005629042748 0.09186724044542131 0.22067604845461103 1.7359605118925936e-07 6.760460157997198 0.6441248556623378 PGQVFIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PGQVFIVK 8 0 Q9BX84-7;Q9BX84-6;Q9BX84-5;Q9BX84-4;Q9BX84-3;Q9BX84-2;Q9BX84 Q9BX84-7 TRPM6 Transient receptor potential cation channel subfamily M member 6 0 7947200.0 1216800.0 3175100.0 3555300.0 False True 1666683.8427835805 3034813.5833483837 2715611.363701921 1.0 1.820869384729768 1.6293500266772214 20.668549031352985 -10.029844818849027 4.482113026676585 0.9999690553621835 1.7251097056391873 0.950280037442682 0.07818745075717175 10291014.986108925 5757178.455181697 3034.9677262981368 0.026765643661688786 9.335878287593984e-11 10.029844818849027 0.7251406502770038 PGSGFTNTMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGSGFTNTMR 10 0 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 5722920.0 2082600.0 458420.0 3181900.0 False True 2016489.0029576046 641469.4966287193 2348464.935046118 1.0 0.3181120728592467 1.164630668256361 20.94341410726643 -6.692330349461003 1.8582432121698946 0.5734296367588466 1.1617796774996265 0.3812799244572421 0.28825668332760435 0.41169341629263373 2.758047611946997 0.12401648839843424 0.3219893245746758 2.030811670648538e-07 6.692330349461003 0.5883500407407799 PGTYVIYVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PGTYVIYVR 9 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 5329100.0 1713300.0 1507700.0 2108100.0 False True 2246152.891620799 1282757.0369685704 1889974.0343231016 1.0 0.5710907043567044 0.8414271536784468 21.0990247020831 -10.478476222863218 6.031021835083453 1.000210205166732 0.7062589290175758 0.6115292293125664 0.11036439328567221 0.0003121562157575721 2.6993125944217343e-05 0.10693542006060222 0.035619954767474475 3.322949774911501e-11 10.478476222863218 -0.2939512761491563 PGTYVIYVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PGTYVIYVR 9 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 9302900.0 2581800.0 1578800.0 5142300.0 False True 2499842.1722058677 2209223.073333233 3795377.3643067586 1.0 0.8837450211441983 1.518246794339703 21.253405582386094 -6.859425267764339 1.1885565617462526 0.9370127293206787 1.5486477070702935 0.9529397237873595 0.059834568889430215 0.14740377506973507 0.3959958158585155 0.039271686805258756 0.09161818114523201 1.3822122328314037e-07 6.859425267764339 0.6116349777496148 PGTYVIYVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PGTYVIYVR 9 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 5883300.0 1713300.0 2076800.0 2093200.0 False True 2346753.310191573 1985040.1089407941 1598829.2708072057 1.0 0.8458665426485534 0.6812941368245852 21.16223476360599 -6.970292600285303 0.2511014779387946 1.051524964368461 0.47080885848123233 0.9999845731683603 0.0005110962933284052 0.07620788646454547 0.008689885726842024 0.0036433498418118855 0.015744469916809625 1.0707976261146476e-07 6.970292600285303 -0.5807161058872287 PGTYVIYVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PGTYVIYVR 9 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 5983600.0 2581800.0 2071400.0 1330400.0 False True 2146881.0931329518 2060240.957059293 1608580.4889254135 1.0 0.9596437192768676 0.7492638945261779 21.03381085782037 -6.93887878774536 0.6699135647597285 1.0024134379158927 0.6943547958708216 0.9980133133498972 0.004899723022694598 0.08828192609303727 0.056967161494082055 0.00472992590922296 0.018198250549872147 1.1511216239209314e-07 6.93887878774536 -0.30805864204507105 PHASIMFCTVGVLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PHASIMFCTVGVLLR 15 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 21347400.0 5577800.0 7316200.0 8453400.0 False True 8461930.391801547 6010566.94826849 6782581.784743151 1.0 0.7103068295257908 0.8015407206982634 23.012555387396628 -10.462437290320052 8.669496937943064 1.0000053349114089 0.7559237751120271 0.9051488265994129 0.03724608010352806 3.840709295650917e-06 2.381599725619168e-07 0.03606414993672628 0.012021120662705975 3.447963896377858e-11 10.462437290320052 -0.24408155979938173 PHPLLVEK(ub)GEYCQTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PHPLLVEKGEYCQTR 15 1 Q06587;Q06587-2 Q06587 RING1 E3 ubiquitin-protein ligase RING1 1 6902400.0 2291800.0 3075600.0 1535000.0 True False 3004571.9938227693 2616732.4685949003 1376172.924759718 1.0 0.8709168806654508 0.45802627714997407 21.518728060637354 -6.9500014405121835 0.5588324206556106 1.005433414013303 0.3038167112387433 0.9992013638261723 0.006532356754090916 0.08348525709042949 0.03596064883310906 0.007012228082549399 0.03431372033191005 1.122014732683015e-07 6.9500014405121835 -0.7016167027745597 down PHPLLVEK(ub)GEYCQTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PHPLLVEKGEYCQTR 15 1 Q06587;Q06587-2 Q06587 RING1 E3 ubiquitin-protein ligase RING1 1 5779500.0 2291800.0 2324200.0 1163500.0 True False 3139140.393566247 2221509.1588983987 888705.2630346754 1.0 0.7076807279634392 0.283104656566524 21.581938122160246 -7.10712569782455 0.3724163689391404 1.0351548673742823 2.2610327961589373e-12 0.9998693036216173 0.0033648129788651105 0.07700266729659215 0.017798785433215836 0.006669499160461752 0.036306605117408755 7.814016108372668e-08 7.10712569782455 -1.0351548673720212 down PIDVQVITHHMQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PIDVQVITHHMQR 13 0 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 0 20917700.0 7152000.0 5858600.0 7907100.0 False True 9376341.260066524 4984519.716643941 7088949.142258995 1.0 0.5316060474326822 0.7560464093228514 23.160593648176278 -10.079135312064405 5.034359001593061 1.0000082356603472 0.6438262283763384 0.7705287981221483 0.09162739405771231 8.469910969815375e-06 1.549383719766653e-06 0.08871989242606783 0.02957261426944829 8.33421477082116e-11 10.079135312064405 -0.35618200728400884 PIDVQVITHHMQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PIDVQVITHHMQR 13 0 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 0 18739300.0 5491800.0 4436000.0 8811500.0 False True 5317465.815059337 6207317.933434403 6503503.81066624 1.0 1.1673451507398427 1.2230457208108385 22.342307422737598 -13.99999999152049 0.15370668934127263 0.18584856128338875 1.2817906196911115 0.9995543391624749 0.0020009499760070912 11.97372181914527 0.12365316394822626 2.908862719235765 0.05315044992464233 1.0000000195247944e-14 13.99999999152049 1.0959420584077229 PIDVQVITHHMQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PIDVQVITHHMQR 13 0 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 0 25962100.0 7152000.0 4994100.0 13816000.0 False True 9796287.675532687 4773444.14871978 10552945.349451717 1.0 0.4872707199730348 1.0772392256108265 23.22380370969917 -6.676945902250471 1.9129145526372522 0.6747046403006236 1.0749353428448827 0.3101640873845225 0.21745334257092203 0.44532001845514674 3.1478769262937694 0.09130863531831411 0.24175120528067645 2.1040405125591754e-07 6.676945902250471 0.4002307025442591 PIDVQVITHHMQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PIDVQVITHHMQR 13 0 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 0 15616100.0 3813500.0 7538800.0 4263800.0 False True 4936650.925323239 7119259.152862191 3487832.150282502 1.0 1.4421232654597795 0.7065178808554563 22.235101203848206 -6.743949044483587 1.6722398602585204 1.261850078066714 0.7057039936711647 0.6225449644621175 0.18575366406931176 0.310713085547874 1.707470562381021 0.0878241295020079 0.21458528346473266 1.803229300282656e-07 6.743949044483587 -0.5561460843955492 PIFFNLNIAAAKPTPPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PIFFNLNIAAAKPTPPK 17 1 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;H7C1M2;J3QSZ5;H7C2G8;P18583-3 P18583-2;P18583-3 SON Protein SON 0 33708000.0 10346000.0 11345000.0 12017000.0 False True 15695638.393914945 9320396.11111041 9641834.682761801 1.0 0.5938207721913268 0.6143002559551737 23.90386037353964 -10.096339651646824 6.748463178068417 1.0000003157007902 0.6040605140732608 0.9979975056172563 0.008360714236174066 3.971429740987606e-08 5.317798927050412e-09 0.008095233203192853 0.002698408916591619 8.010513346651203e-11 10.096339651646824 -0.3959398016275294 PIFFNLNIAAAKPTPPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PIFFNLNIAAAKPTPPK 17 1 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;H7C1M2;J3QSZ5;H7C2G8;P18583-3 P18583-2;P18583-3 SON Protein SON 0 7222900.0 3222100.0 1104100.0 2896700.0 False True 2679318.9132325076 1098151.9941533087 3502386.577172458 1.0 0.4098623679061876 1.3071928690067534 21.353434881432396 -6.729340637354026 1.7259706714099285 0.6445914834907313 1.3065618430361299 0.5560714560736553 0.2480923223089284 0.33746878097959926 1.9692604992131146 0.1139314199249012 0.2828880634135962 1.8649163764164144e-07 6.729340637354026 0.6619703595453986 PIFFNLNIAAAKPTPPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PIFFNLNIAAAKPTPPK 17 1 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;H7C1M2;J3QSZ5;H7C2G8;P18583-3 P18583-2;P18583-3 SON Protein SON 0 26930100.0 10346000.0 11133000.0 5451100.0 False True 13393100.95014929 10513438.763306467 4459055.733009274 1.0 0.7849891374998764 0.3329367671912881 23.67498669563209 -6.959056009403192 0.4485407201891577 1.014797142800373 0.08525163292012183 0.9997335666006113 0.004537726010948685 0.08004008884566084 0.02239049666432941 0.006029178029613396 0.037400445196076784 1.0988641137264278e-07 6.959056009403192 -0.9295455098802512 down PIFGLTSNYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PIFGLTSNYK 10 0 Q96ST2-2;Q96ST2-3;Q96ST2;A0A1B0GW95 Q96ST2-2 IWS1 Protein IWS1 homolog 0 19912600.0 4828700.0 6120200.0 8963700.0 False True 6330472.46119732 5207090.016352746 8036222.3098818865 1.0 0.822543664516297 1.2694506388172404 22.593881745437542 -6.798985608061351 1.4603194924833776 0.9019653151672771 1.2754484922540905 0.829121888043143 0.07595044362609313 0.22219970409266276 0.9356375367241524 0.0409202987251902 0.0952135657973805 1.5885993917860227e-07 6.798985608061351 0.37348317708681344 PIGEQEEEEYETK(ub)GGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PIGEQEEEEYETKGGR 16 1 Q9ULT8;A0A087X2H1;H0YJP0;H0YJD4 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 13405800.0 4811400.0 4306100.0 4288300.0 True False 6307791.993663874 3663646.665046331 3844587.8522782396 1.0 0.5808128531705602 0.6094981978067915 22.588703655790987 -9.949631508596463 5.242312859501339 1.0000011932121287 0.5951555255363936 0.9962487769997879 0.011710742919120444 101911773954.06502 20412251437.144627 1614195.1612248078 0.0040128118058628095 1.122970871673696e-10 9.949631508596463 -0.40484566767573504 PIGEQEEEEYETK(ub)GGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PIGEQEEEEYETKGGR 16 1 Q9ULT8;A0A087X2H1;H0YJP0;H0YJD4 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 13574200.0 3197000.0 6247000.0 4130200.0 True False 3095512.984949321 8741459.677674629 3048376.7166559272 1.0 2.823913102667131 0.9847727118178554 21.56174708038451 -6.648032917374132 2.015145697763248 2.18532991962979 0.9924260001996227 0.1863209764499566 0.7788338620471967 0.5133307020347547 3.993164535657622 0.31366009211004997 0.8628053163474826 2.248884145078409e-07 6.648032917374132 -1.1929039194301674 PIGEQEEEEYETK(ub)GGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PIGEQEEEEYETKGGR 16 1 Q9ULT8;A0A087X2H1;H0YJP0;H0YJD4 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 20826400.0 7146000.0 9129500.0 4550900.0 True False 10841004.442578405 7500269.3958909325 3651412.6202696743 1.0 0.6918426641754131 0.33681497315217673 23.369995095921155 -7.1195802714615635 0.29664024942443085 1.0704234348711072 1.0586122603777362e-16 0.9999533876163268 0.0018499878283924432 0.07854146796039396 0.012887639729275466 0.007616897855741443 0.03399799129909021 7.593110648123464e-08 7.1195802714615635 -1.0704234348711072 down PIGEQEEEEYETK(ub)GGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PIGEQEEEEYETKGGR 16 1 Q9ULT8;A0A087X2H1;H0YJP0;H0YJD4 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 10180700.0 4811400.0 3166000.0 2203300.0 True False 6590304.603196019 3026115.651438056 1682925.9183878845 1.0 0.45917690207680506 0.25536390496605216 22.651913717313878 -13.831653511070106 0.13863399742815255 3.4682584247824773 9.935369734950985e-19 0.9996140218180101 0.006172934226853194 11.248987874082408 0.11500886285936705 7.571514143040703 0.22653935428525188 1.4734876118546325e-14 13.831653511070106 -3.4682584247824773 PIGEQEEEEYETK(ub)GGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PIGEQEEEEYETKGGR 16 1 Q9ULT8;A0A087X2H1;H0YJP0;H0YJD4 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 1 13154400.0 3197000.0 5161500.0 4795900.0 True False 2658447.151113969 5133693.975022462 5798700.516263824 1.0 1.9310874669339546 2.181235957176728 21.342152355818786 -10.606757281668333 0.27268292717660336 7.759021294284293e-14 2.2838849503119403 0.9991300045126654 0.014991032822250368 2.2679684842828656 0.13569161876138872 1.6270283547815405 0.1014629862490167 2.473105927337009e-11 10.606757281668333 2.2838849503118626 PIIGILMQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PIIGILMQK 9 0 Q92820 Q92820 GGH Gamma-glutamyl hydrolase 0 2932310.0 907720.0 746690.0 1277900.0 False True 1190029.7103729842 635286.7625748239 1145675.166482373 1.0 0.5338410940813483 0.962728204595237 20.182566161742017 -10.467524261026572 8.930906628563422 1.0000044199626017 0.7482846493382926 0.31472787846719474 0.17509242966928096 1.540949062410875e-05 9.187742901971676e-07 0.16953549057594874 0.056510838679676545 3.407812871769506e-11 10.467524261026572 -0.25171977062430906 PIIGILMQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PIIGILMQK 9 0 Q92820 Q92820 GGH Gamma-glutamyl hydrolase 0 4093980.0 1475700.0 906080.0 1712200.0 False True 1428854.711257341 1267882.4691447779 1263723.4551010304 1.0 0.8873417704093137 0.8844310377708025 20.446427797161114 PIIGILMQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PIIGILMQK 9 0 Q92820 Q92820 GGH Gamma-glutamyl hydrolase 0 4374320.0 907720.0 1803500.0 1663100.0 False True 1243328.6142106445 1723815.4066230378 1270310.0326196577 1.0 1.3864519700750564 1.0217009550818896 20.245776223264908 -9.804362569721528 6.207829584631187 0.9999999922824686 1.2040764625786198 0.2944728616916297 0.14890897831644342 1.5996691357223154e-08 3.1147944169079956e-09 0.14418050365099613 0.0480601660932852 1.5690523377548287e-10 9.804362569721528 0.20407647029615117 PIIGTVSMDDMMLEMLCTKI ddPTM_RPMI8226_Bortezomib_2h_R1 1 PIIGTVSMDDMMLEMLCTKI 20 1 P51843 P51843 NR0B1 Nuclear receptor subfamily 0 group B member 1 0 64118900.0 8277900.0 26618000.0 29223000.0 False True 8015122.595593373 37246706.21103629 21568619.628791824 1.0 4.6470538368950365 2.6909906082596935 22.934293156666186 -10.223700097050301 6.78291315340589 0.9999855439188108 3.669022222577352 0.7128443463169218 0.7985594691296042 0.0001748663193501211 2.0009983833561827e-05 0.7732060350471753 0.25773396040793267 5.974477129162068e-11 10.223700097050301 2.669036678658541 PIIGTVSMDDMMLEMLCTKI ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PIIGTVSMDDMMLEMLCTKI 20 1 P51843 P51843 NR0B1 Nuclear receptor subfamily 0 group B member 1 0 38803100.0 8277900.0 26186000.0 4339200.0 False True 6883440.623148685 26044930.820485994 5246506.657806039 1.0 3.7837082131424395 0.7621924768497726 22.714698432100462 -6.664537654852723 1.9569598598059765 2.7851049672399366 0.7747024446096258 0.2550410306180927 1.1839662776122002 0.4737491872823755 3.492399465251074 0.4880137559156155 1.3131022007044777 2.16502215616586e-07 6.664537654852723 -2.0104025226303106 PIKPSPPYFGLLLASVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PIKPSPPYFGLLLASVGR 18 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 58913000.0 19796000.0 22947000.0 16170000.0 False True 19167586.815782577 32109856.767024126 11934591.910398126 1.0 1.6752164513784746 0.6226444687638608 24.192165378470996 -6.733484578450508 1.7108290497219143 1.404761928713629 0.6228956081733358 0.5752300918292399 0.28377453110359724 0.32973395940930333 1.8923218060326272 0.13137079886443986 0.3246717575311466 1.847206386990871e-07 6.733484578450508 -0.7818663205402933 PIKPSPPYFGLLLASVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PIKPSPPYFGLLLASVGR 18 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 202737000.0 56421000.0 60052000.0 86264000.0 False True 85594781.92761202 49335251.411582485 69213882.58914563 1.0 0.5763815305155585 0.8086226873932595 26.351019513213917 -10.09533720198571 5.211259906379217 1.000005934842164 0.6925021089539761 0.7003711620526589 0.09481205527218282 6.537723602668366e-06 1.1350866683604892e-06 0.09180314880905513 0.030600459257187476 8.02902477505479e-11 10.09533720198571 -0.3075038258881878 PIKPSPPYFGLLLASVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PIKPSPPYFGLLLASVGR 18 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 62988800.0 2985800.0 15120000.0 44883000.0 False True 4089730.948211061 14451948.404846318 34282559.79440081 1.0 3.533716175429076 8.382595390387909 21.963574504801876 -6.960897914518216 0.42258962334818756 0.791552598111568 11.308449835936068 0.9998020630211545 0.043092436618415546 0.0793819270974213 0.019957681375084184 0.06283480003084864 0.40334902400517825 1.0942135424366958e-07 6.960897914518216 10.5168972378245 PIKPSPPYFGLLLASVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PIKPSPPYFGLLLASVGR 18 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 53485000.0 19796000.0 15916000.0 17773000.0 False True 16461251.111495852 15830257.348921334 21489252.126932796 1.0 0.9616679340895384 1.3054446458158697 23.972570653905272 -6.879214767757029 1.0841136465148096 0.976477433905513 1.329449344658634 0.9730489354133007 0.025252459888996225 0.12833054333185134 0.27647777196489615 0.01795506283967174 0.043336644212102635 1.320642387236464e-07 6.879214767757029 0.35297191075312095 PIKPSPPYFGLLLASVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PIKPSPPYFGLLLASVGR 18 1 A0A3B3IRI2;P17812;B4E1E0;P17812-2 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 191293000.0 56421000.0 77195000.0 57677000.0 False True 73038096.72418056 72899030.39014125 47180377.81599608 1.0 0.9980959753844013 0.6459694314621451 26.122145835306366 -6.908086647152142 0.9086685122833287 1.011573197789337 0.6022777407733486 0.990179205673118 0.01649464992747544 0.10569683180043159 0.1457320883755445 0.013377914322189504 0.036457286864604366 1.235700871152215e-07 6.908086647152142 -0.40929545701598835 PILSATVTK(ub)RK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 PILSATVTKRK 11 2 Q8IZT6;Q8IZT6-2 Q8IZT6 ASPM Abnormal spindle-like microcephaly-associated protein 2 2992230.0 984150.0 929680.0 1078400.0 True False 1290230.1805221566 790975.3678642568 966817.5127432445 1.0 0.6130498106501809 0.7493372324866662 20.299197038596002 -10.592853242555067 7.103355459314067 1.000408713512164 0.6811935215684235 0.8794591582753587 0.055639106976472445 0.00036057991532117457 2.066751193475494e-05 0.053938984923026914 0.017957444559810902 2.5535640610913298e-11 10.592853242555067 -0.3192151919437405 PIMSNHTATHILNFALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PIMSNHTATHILNFALR 17 0 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 52889000.0 10771000.0 25078000.0 17040000.0 False True 14120885.306512367 21336460.153278388 15276864.259221867 1.0 1.5109860104478217 1.0818630650711665 23.75132720517732 -12.342915131679547 11.747408236465573 1.0361170467920584 1.2667820839835793 0.0 0.2345231201045389 0.0 0.0 0.0 0.06477114864216507 4.5403033301358357e-13 12.342915131679547 0.23066503719152087 PIMSNHTATHILNFALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PIMSNHTATHILNFALR 17 0 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 199246000.0 43655000.0 62061000.0 93530000.0 False True 42269195.920538835 86842280.94383954 69031687.16014446 1.0 2.0545051556479312 1.6331440818016978 25.333103332707882 -10.145059420409629 4.800467041285821 0.9999364385130468 1.8438246186519072 0.842452618582489 0.1720199380908973 22003218.669637598 46500484.87753197 10070.401285452173 0.05888699586512594 7.16045433780793e-11 10.145059420409629 0.8438881801388604 PIMSNHTATHILNFALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PIMSNHTATHILNFALR 17 0 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 96741300.0 10771000.0 34029000.0 51941300.0 False True 14753329.775330326 32525486.261145152 39673834.704652384 1.0 2.204620025204914 2.6891444378199085 23.81453726670021 -9.762863514244659 0.2407442196540227 2.4779933425619087e-16 2.9971468083903607 0.9991538296676702 0.020658160697389287 1.1889731730784214 0.10326986022196562 1.0679870312129354 0.22564245483050335 1.7263803564135293e-10 9.762863514244659 2.9971468083903603 PIMSNHTATHILNFALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PIMSNHTATHILNFALR 17 0 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 102400000.0 43655000.0 27289000.0 31456000.0 False True 36301066.74441049 27141988.74055757 38033304.163888894 1.0 0.7476912161193389 1.0477186368013587 25.11350860814216 -6.683720928450944 1.8888044932357138 0.8408947928622679 1.0466076678919711 0.34114588134646784 0.10684903002060729 0.4303251087454236 2.9713430060047297 0.045340736699953206 0.11901010994028577 2.0714720201060608e-07 6.683720928450944 0.20571287502970326 PINGAIFIFNPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PINGAIFIFNPR 12 0 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 2101690.0 563960.0 771060.0 766670.0 False True 739357.021396409 656020.8535683389 687342.3428179369 1.0 0.8872856205914231 0.9296487663291099 19.49591165696603 -10.405158214816382 7.711922370014855 1.0000023670264526 0.9084671937103385 0.8615852388174358 0.017294681826082098 7.03882577385716e-07 5.426392586243586e-08 0.016745936833284604 0.005581834557531004 3.934067300642323e-11 10.405158214816382 -0.09153517331611416 PINGAIFIFNPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PINGAIFIFNPR 12 0 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 3032390.0 563960.0 758230.0 1710200.0 False True 772471.2524459473 724728.8914686923 1306285.9826746066 1.0 0.938195290988391 1.6910480209307366 19.55912171848892 -6.886996214212185 1.0400303825773416 0.9565873688731468 1.752104467914515 0.978903408368216 0.04956755829730036 0.12161238923032984 0.2363766938342134 0.03645089597359302 0.08994003970886162 1.2971905786728333e-07 6.886996214212185 0.7955170990413682 PIPTCISSATGLIENRPQSPATGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PIPTCISSATGLIENRPQSPATGR 24 1 Q92558 Q92558 WASF1 Wiskott-Aldrich syndrome protein family member 1 0 77246000.0 24730000.0 31432000.0 21084000.0 False True 37517218.00517262 25822714.020663083 16916738.15855451 1.0 0.6882896812099134 0.4509059855190261 25.161049516613183 -7.526319411345894 0.16627866304689626 1.2643074262295615 2.5349525564836946e-16 0.9999755451735097 0.0011119102879389735 0.13183648533574227 0.015669291693100735 0.039025941004213374 0.0693982400830305 2.9763266199490902e-08 7.526319411345894 -1.2643074262295613 down PIPTCISSATGLIENRPQSPATGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PIPTCISSATGLIENRPQSPATGR 24 1 Q92558 Q92558 WASF1 Wiskott-Aldrich syndrome protein family member 1 0 61346000.0 24730000.0 25650000.0 10966000.0 False True 32013472.501178365 24222554.95183791 8970300.520661829 1.0 0.7566362865180063 0.28020392103142344 24.932175838705632 -6.9615443932004055 0.4291615734376906 1.0191035805038693 1.387439967602544e-18 0.9997871297045953 0.004361645401580022 0.0793626870400413 0.02052395034281013 0.006201656288983582 0.039478279125381856 1.0925859383058775e-07 6.9615443932004055 -1.0191035805038693 down PISINYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PISINYR 7 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 4960900.0 2109800.0 1388800.0 1462300.0 False True 2889850.0752011864 1327438.223852552 1116934.8570138435 1.0 0.45934501420809454 0.3865027001222838 21.46256321728392 -13.999999999999998 0.2824802430321018 5.467081829946057 0.36510480360948605 0.9996106788691796 0.005399581475673782 15.534009524744272 0.16840329062447248 40.14716391108637 0.028479253850260053 1.0000000000000041e-14 13.999999999999998 -5.101977026336571 PITVSYAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PITVSYAFK 9 0 Q15427;Q5SZ64 Q15427 SF3B4 Splicing factor 3B subunit 4 0 12248700.0 4945000.0 3873600.0 3430100.0 False True 6482942.887448113 3295673.979174542 3075186.155842549 1.0 0.508360791756384 0.4743503389173057 22.62821743263943 -13.999999999999998 0.37934498798621763 8.264097093687676 0.47132799174697265 0.9998064613533099 0.0033413206804124547 23.952712304203757 0.20079725969778234 142.05417007658127 0.00923647406449178 1.0000000000000041e-14 13.999999999999998 -7.792769101940703 PK(ub)EISEIQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PKEISEIQR 9 1 Q8NBR6-2;Q8NBR6;H0YM15;J3KNL7 Q8NBR6-2 FAM63B Protein FAM63B 1 28634400.0 10145300.0 8308400.0 10180700.0 True False 13300586.54722494 7068819.105889536 9127298.82417021 1.0 0.5314667199669016 0.6862328057310033 23.664986533254826 -10.403373284484132 5.2362287951590964 1.0002939473911947 0.6088497628489407 0.8949222045239684 0.06318298993501972 0.00021697555124376705 2.4722659965608037e-05 0.061221863021606315 0.02039222231515419 3.950269408334463e-11 10.403373284484132 -0.39144418454225405 PK(ub)EISEIQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PKEISEIQR 9 1 Q8NBR6-2;Q8NBR6;H0YM15;J3KNL7 Q8NBR6-2 FAM63B Protein FAM63B 1 31621100.0 7659400.0 10679900.0 13281800.0 True False 7416256.539543581 14944439.76494276 9802898.134540858 1.0 2.015092073104376 1.3218121679410186 22.82225971915681 -10.502538902935749 4.964618907972455 0.9977334487909679 1.668452120522727 0.5534806295713098 0.28303033609599276 0.007119707297120464 0.000713402910808874 0.2747860045469969 0.0913476481809242 3.143844790454561e-11 10.502538902935749 0.670718671731759 PK(ub)EISEIQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PKEISEIQR 9 1 Q8NBR6-2;Q8NBR6;H0YM15;J3KNL7 Q8NBR6-2 FAM63B Protein FAM63B 1 58430300.0 22793900.0 26208900.0 9427500.0 True False 34580012.75730303 21531717.023929637 7564150.492779958 1.0 0.6226636518340296 0.21874342690005133 25.04343506543275 -7.527541813101378 0.3599959328432472 1.0548552523443304 1.789155902474718e-11 0.9992726227235345 0.008603627862203903 0.12181330525476267 0.04263077251446771 0.021244134633746272 0.06740985060044122 2.967960979695248e-08 7.527541813101378 -1.054855252326439 down PK(ub)EISEIQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PKEISEIQR 9 1 Q8NBR6-2;Q8NBR6;H0YM15;J3KNL7 Q8NBR6-2 FAM63B Protein FAM63B 1 26935200.0 10145300.0 6615000.0 10174900.0 True False 13896291.576423608 6322727.427120255 7771798.178643337 1.0 0.4549938659784146 0.5592713808501931 23.728196594777717 -9.942778925468378 5.836813676331357 1.000000332604135 0.5071326234142108 0.9675180895386251 0.042571117181144126 1.8421340744383794e-07 3.3358369288535204e-08 0.04121933460646008 0.013739768989200214 1.1408303714021554e-10 9.942778925468378 -0.49286770918992406 PK(ub)EISEIQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PKEISEIQR 9 1 Q8NBR6-2;Q8NBR6;H0YM15;J3KNL7 Q8NBR6-2 FAM63B Protein FAM63B 1 33351300.0 7659400.0 16117000.0 9574900.0 True False 6369130.468952872 16030174.522025978 11576967.32066441 1.0 2.516854474903141 1.8176684206891025 22.602664994591088 -10.137700266727935 5.0269161276320355 0.9999459918215775 2.167261447798586 0.787961203958546 0.28544151135760715 0.000172782370854982 2.963860717839336e-05 0.276390231846497 0.09212585164913267 7.282822634084168e-11 10.137700266727935 1.1673154559770085 PK(ub)EISEIQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PKEISEIQR 9 1 Q8NBR6-2;Q8NBR6;H0YM15;J3KNL7 Q8NBR6-2 FAM63B Protein FAM63B 1 66164100.0 22793900.0 37883200.0 5487000.0 True False 29507152.88494174 35774966.617990784 4488422.301374379 1.0 1.2124167573025206 0.1521130255730276 24.8145613875252 -6.854602278721543 1.21263412423234 1.1139729249547832 0.10579953262337984 0.9467423185833866 0.10570675656801669 0.15246793402338557 0.4291261756659986 0.06812072910442618 0.15817558915271462 1.3976477228917191e-07 6.854602278721543 -1.0081733923314034 down PK(ub)FSVCVLGDQQHCDEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PKFSVCVLGDQQHCDEAK 18 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 16455300.0 3517800.0 3351500.0 9586000.0 True False 4553861.446204827 3164986.0787947206 7841446.360666093 1.0 0.6950115009389249 1.7219334521477654 22.1186589666586 -6.827125892347198 1.3406299577907375 0.8366794188958947 1.7479932947142853 0.9000139262154262 0.13615930979391494 0.18438724310279134 0.6491181567192477 0.07976475492448373 0.18360412884678903 1.4889294075046172e-07 6.827125892347198 0.9113138758183906 PK(ub)GGSGDTLAPQ ddPTM_RPMI8226_Bortezomib_1h_R1 1 PKGGSGDTLAPQ 12 1 Q96F44-3;Q96F44;R4GMV1 Q96F44-3 TRIM11 E3 ubiquitin-protein ligase TRIM11 1 5489300.0 2332600.0 1764100.0 1392600.0 True False 3058061.188930534 1500903.1564079435 1248507.1107624646 1.0 0.4908021990668015 0.4082675373801441 21.54418584328367 -13.999999999999998 0.25607890998852567 4.652611108506775 0.37694918274641387 0.9995544402090779 0.005523406893676107 14.2473299443715 0.16012827595466844 26.866578906608495 0.036844020482015634 1.0000000000000041e-14 13.999999999999998 -4.275661925760361 PK(ub)GGSGDTLAPQ ddPTM_RPMI8226_Bortezomib_8h_R1 1 PKGGSGDTLAPQ 12 1 Q96F44-3;Q96F44;R4GMV1 Q96F44-3 TRIM11 E3 ubiquitin-protein ligase TRIM11 1 11712200.0 2789900.0 3809700.0 5112600.0 True False 4232482.269010564 3129829.2696780376 4102092.3690678165 1.0 0.7394784126076691 0.9691930428397921 22.013072593626045 -10.242414971828737 7.0912025008279675 1.000000618250131 0.8543357278817018 0.3490120701411331 0.09378060508680264 9.1661233301283e-07 9.788585710351004e-08 0.09080306604037777 0.030267560141536764 5.722489812231104e-11 10.242414971828737 -0.14566489036842933 PK(ub)GGSGDTLAPQ ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PKGGSGDTLAPQ 12 1 Q96F44-3;Q96F44;R4GMV1 Q96F44-3 TRIM11 E3 ubiquitin-protein ligase TRIM11 1 4964400.0 2332600.0 1172700.0 1459100.0 True False 3195025.256144792 1120886.2363996862 1114490.6311077748 1.0 0.3508223398998039 0.348820601328376 21.607395904806562 PK(ub)GGSGDTLAPQ ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PKGGSGDTLAPQ 12 1 Q96F44-3;Q96F44;R4GMV1 Q96F44-3 TRIM11 E3 ubiquitin-protein ligase TRIM11 1 12506600.0 2789900.0 3635900.0 6080800.0 True False 3611580.5471507343 3433558.9687870336 4974156.794276904 1.0 0.9507081245898984 1.3772797614056096 21.784198915718495 -6.878124582931856 1.0901503479837742 0.9701417831033513 1.4064505891525452 0.9721433725210337 0.03180091034288987 0.12930691958694013 0.28240435758642796 0.02250693053473689 0.054179901012913256 1.3239616853564256e-07 6.878124582931856 0.43630880604919386 PK(ub)GLEGERPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PKGLEGERPAR 11 2 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 531404700.0 135895700.0 258099000.0 137410000.0 True False 178160578.71583092 219591635.26202217 123192131.32979329 1.0 1.2325489558061802 0.6914668341209577 27.408602908625426 -6.78990995400447 1.496538204981441 1.129992658464966 0.6857164866296194 0.8010314582767983 0.09885588334058859 0.23551429830547382 1.042001789926464 0.05199199186405171 0.12174206943604977 1.6221463960030836e-07 6.78990995400447 -0.4442761718353466 PK(ub)GLEGERPAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PKGLEGERPAR 11 2 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 835036700.0 284477000.0 345449700.0 205110000.0 True False 275446433.34983695 483389566.7063875 151385537.831896 1.0 1.7549312976307365 0.5496006464517382 28.037196541218396 -6.737357524321342 1.696406616790248 1.450534522504224 0.5492921022376847 0.5930902313908798 0.3172134802592643 0.32257596994317134 1.821695895812797 0.1479940808680867 0.36421794410715486 1.8308066265694855e-07 6.737357524321342 -0.9012424202665394 PK(ub)GLEGERPAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PKGLEGERPAR 11 2 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 361769600.0 202504600.0 71088000.0 88177000.0 True False 307214283.26932013 58401790.98692087 70748777.30064791 1.0 0.1901011579455855 0.2302913020441365 28.194670051729528 -10.062534087223854 5.380518821284506 1.0000071361866338 0.21019622999412674 0.998061706978194 0.016407557624305756 91029692.71444465 0.12397082534626554 8048.012204620262 0.00561674338985374 8.658963575843702e-11 10.062534087223854 -0.7898109061925072 PK(ub)GLEGERPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PKGLEGERPAR 11 2 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 462524600.0 135895700.0 224468900.0 102160000.0 True False 186140012.7332058 214551121.77861172 78031912.05124415 1.0 1.1526330025889036 0.41921084513455564 27.471812970148317 -6.852395628566004 1.2233836749244007 1.0816528566100507 0.38849324672848545 0.9437302345310955 0.07495151181266425 0.15484201280055299 0.4447417223628937 0.047907628717930445 0.1110505396522255 1.4047672424491195e-07 6.852395628566004 -0.6931596098815653 down PK(ub)GLEGERPAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PKGLEGERPAR 11 2 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 829474680.0 284477000.0 480435000.0 64562680.0 True False 236555229.96792278 477846801.29611945 78062437.88389587 1.0 2.020022137582484 0.329996668830705 27.817601816652672 -6.743270817037824 1.6744996656343702 1.6045902799778904 0.32823772609558793 0.6196271487226409 0.42855361497087535 0.3119308043313364 1.718514783298022 0.20235630731016183 0.4948351614612673 1.8060475609688472e-07 6.743270817037824 -1.2763525538823024 PK(ub)GLEGERPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PKGLEGERPAR 11 2 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 359873900.0 202504600.0 123821300.0 33548000.0 True False 262146196.66243958 116930535.80732957 27442608.231548708 1.0 0.4460508574835388 0.10468436536916843 27.965796373821977 -8.404568304521176 0.36457193331664767 1.1118170406410846 1.4380014827136735e-15 0.9977236812766842 0.01760191428055491 0.1457547174498656 0.10171989674802913 0.09158367972495395 0.08553295880184077 3.939414648513802e-09 8.404568304521176 -1.1118170406410832 PK(ub)HCQYTWDTQMNSNLGITAACK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PKHCQYTWDTQMNSNLGITAACK 23 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 14932300.0 3592400.0 6838700.0 4501200.0 True False 4920607.360959683 6536543.621443282 3438109.265123924 1.0 1.3284017890361481 0.6987164414706273 22.230404970775776 -6.764945319675003 1.5935445423061643 1.189570085984675 0.6958090211479141 0.7109795406128899 0.13824405445409724 0.27466725685188453 1.3756264344157705 0.06841047628608914 0.1636290801522423 1.7181246959218764e-07 6.764945319675003 -0.49376106483676085 PK(ub)KPVCGVCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PKKPVCGVCR 10 2 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 4427100.0 1671500.0 2081400.0 674200.0 True False 2191352.686829025 1770863.2332336546 604440.2513830632 1.0 0.808114204471652 0.2758297443474115 21.063390266610362 -6.953197328491055 0.5225661271107334 1.0088688534063668 0.05121674402846044 0.9994288930539283 0.007320740609230347 0.08222672247928547 0.030841444994272497 0.008259991479690986 0.04397852073287726 1.1137883514452757e-07 6.953197328491055 -0.9576521093779063 down PK(ub)LIGEELAQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PKLIGEELAQLK 12 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 132008400.0 53412200.0 30829200.0 47767000.0 True False 70023911.44448054 26229603.531280402 42824529.05341856 1.0 0.37458066809188345 0.6115700789918399 26.06134431529452 -10.237434991996302 5.525929503829973 1.0000309786803532 0.4930753735418621 0.859165460609931 0.09675052185803475 3.692753646311762e-05 5.09580305864988e-06 0.0936839999808398 0.031226096657740787 5.788486276666824e-11 10.237434991996302 -0.5069556051384911 PK(ub)LIGEELAQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PKLIGEELAQLK 12 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 183270100.0 43091400.0 52545700.0 87633000.0 True False 41723487.094039775 73527472.03220552 64679288.36635244 1.0 1.762256157221072 1.5501889432341314 25.314356402199707 -10.12919038310992 4.631389015012933 0.9999402127855358 1.656222550237718 0.9273633268874127 0.08657607761251589 5.4367945693329984e-05 1.0222170959331543e-05 0.08383465795082441 0.02794230889225562 7.426934895201828e-11 10.12919038310992 0.6562823374521821 PK(ub)LIGEELAQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PKLIGEELAQLK 12 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 118444200.0 33902800.0 53147700.0 31393700.0 True False 51433026.22667885 43663077.69012462 25188721.434652492 1.0 0.8489307531252386 0.48973827290735694 25.61619170597848 -6.956527595949848 0.48188479491648645 1.0084705438427752 0.31517498635748975 0.999618949729818 0.004177608839013907 0.08096564993976062 0.025897764429141573 0.005084033354592902 0.02962855838734328 1.1052802354096021e-07 6.956527595949848 -0.6932955574852855 down PK(ub)LIGEELAQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PKLIGEELAQLK 12 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 118247900.0 53412200.0 26404300.0 38431400.0 True False 73160133.75043158 25237670.718656316 29354694.83952805 1.0 0.3449647974229877 0.4012389444183443 26.12455437681741 -10.697994871848099 10.471417153016205 1.0004312958640535 0.37310187264490446 0.9939928504312452 0.022973824308166507 0.0002314557103774858 6.675369710526128e-06 0.02225720511426567 0.007414769912018694 2.0044956963228724e-11 10.697994871848099 -0.6273294232191491 PK(ub)LIGEELAQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PKLIGEELAQLK 12 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 135106400.0 43091400.0 57555700.0 34459300.0 True False 35832408.37269705 57245636.020188 41664580.30819866 1.0 1.5975938715804274 1.1627624879366332 25.094761677633983 -10.228520100102449 4.123626873204669 0.9997654922787044 1.380178179669736 0.5047612244372033 0.17751916935078602 125141065.41864704 132.3474353355989 297556.09456155176 0.06076953334920371 5.908536189387991e-11 10.228520100102449 0.38041268739103173 PK(ub)MQEVVANLQYDDGSGMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PKMQEVVANLQYDDGSGMK 19 1 Q16531;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 11408100.0 2999300.0 5128700.0 3280100.0 True False 2494050.8415189655 5101070.675132758 3965953.744531152 1.0 2.0452953846065243 1.5901655565753203 21.25005944429916 -10.201653943412706 5.113951222010735 0.9999324061802471 1.81773047059145 0.8114687667002513 0.18580597423468925 0.00014320587774825113 2.2356177896155422e-05 0.17992061592704628 0.05996862031946903 6.285590106907143e-11 10.201653943412706 0.817798064411203 PK(ub)NVIFEDEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PKNVIFEDEEK 11 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2;B0QYS5 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 16151300.0 5213800.0 5160600.0 5776900.0 True False 6835342.2905110195 4390658.595861244 5179161.8039377285 1.0 0.6423465584095851 0.7577033576105707 22.704582154186696 -10.771248263733254 10.22255528813639 1.001376124894868 0.700024958010078 0.9001615402557919 0.0470942160671855 0.001482243723654661 3.316833016458325e-05 0.04575997775968517 0.015199592877575266 1.6933695117899197e-11 10.771248263733254 -0.30135116688479 PK(ub)NVIFEDEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PKNVIFEDEEK 11 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2;B0QYS5 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 20668200.0 6307600.0 7123700.0 7236900.0 True False 6107368.69060568 9968230.55960473 5341338.787653685 1.0 1.632164531828217 0.8745728411434701 22.54211950997823 -6.685244950200596 1.8829856542165984 1.3980676464619097 0.8773054463214806 0.3484370883953509 0.26762269083656653 0.4269559137252882 2.931085741715985 0.11385172294300715 0.29830289760590967 2.0642155712750744e-07 6.685244950200596 -0.5207622001404292 PK(ub)NVIFEDEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PKNVIFEDEEK 11 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2;B0QYS5 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 16461900.0 5213800.0 6595900.0 4652200.0 True False 7141482.757647133 6304471.328275509 3553446.175066543 1.0 0.8827958481765781 0.4975782054870182 22.767792215709587 -6.949382679992612 0.565581389502021 1.0048985879353243 0.35688807908136677 0.9991519355092121 0.0062500743146462 0.08373460491599917 0.03699575428082047 0.00665543996544491 0.03206228779167084 1.1236144611041256e-07 6.949382679992612 -0.6480105088539575 down PK(ub)NVIFEDEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PKNVIFEDEEK 11 1 B0QYR6;Q9UJY5-4;Q9UJY5;Q9UJY5-6;Q9UJY5-3;Q9UJY5-2;B0QYS5 B0QYR6 GGA1 ADP-ribosylation factor-binding protein GGA1 1 23818800.0 6307600.0 12615600.0 4895600.0 True False 5245048.874058958 12547637.258799467 5919247.3253031075 1.0 2.392282237989766 1.128539975018843 22.322524785412508 -6.623089707054819 2.10605344554654 1.921833068729782 1.1335037961005205 0.09311051450314278 0.5982647820515153 0.5771237921842932 4.868720733625625 0.23310703432610072 0.6629213326225168 2.3818274327296262e-07 6.623089707054819 -0.7883292726292614 PK(ub)PINVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PKPINVR 7 1 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PNP4;P15311 A0A2R8Y5S7;P15311 RDX;EZR Radixin;Ezrin 1 7111530.0 3058500.0 3418500.0 634530.0 True False 4009723.118556136 2908473.1252086316 568874.9224415526 1.0 0.7253551028869908 0.1418738665043783 21.935071187730713 -7.244601737426073 0.5596678093032504 1.0046042500133274 6.478346944803132e-25 0.9981288102627243 0.015477934017405373 0.09300262499999848 0.052539936190173046 0.01561002944930114 0.05447546430000846 5.6937482728023035e-08 7.244601737426073 -1.0046042500133274 down PK(ub)PINVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PKPINVR 7 1 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PNP4;P15311 A0A2R8Y5S7;P15311 RDX;EZR Radixin;Ezrin 1 8476600.0 3514600.0 3774400.0 1187600.0 True False 3403030.9467947707 5281537.603235971 876531.9327636856 1.0 1.552009865855178 0.2575738941161464 21.69838884039916 -6.790836102369089 1.493060927737466 1.3081802344386793 0.24350096183703376 0.8040081169734248 0.23479275215103748 0.23410339550424644 1.0309644391490762 0.12377496816348339 0.28960323329689946 1.6186907972629237e-07 6.790836102369089 -1.0646792726016454 down PK(ub)PINVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PKPINVR 7 1 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PNP4;P15311 A0A2R8Y5S7;P15311 RDX;EZR Radixin;Ezrin 1 5588500.0 3058500.0 1900700.0 629300.0 True False 4189310.10285469 1816720.78922562 480672.3008403277 1.0 0.43365631682115524 0.11473781817029653 21.998281249253605 -8.579365924476692 0.336708188096224 1.151953071722393 3.984556840965765e-24 0.9981600227812069 0.01570306377653882 0.21365300177425645 0.10037080402069457 0.12358947464516966 0.08901235021630104 2.6341110217105013e-09 8.579365924476692 -1.151953071722393 PK(ub)PINVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PKPINVR 7 1 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3;E9PNP4;P15311 A0A2R8Y5S7;P15311 RDX;EZR Radixin;Ezrin 1 8954760.0 3514600.0 4925500.0 514660.0 True False 2922545.6231795913 4898965.353864797 622273.0264810226 1.0 1.6762665106096633 0.21292157821099095 21.478794115833438 -6.7810100433544855 1.5317093605064775 1.3824004940354433 0.20090252670020486 0.7710687339515572 0.2861134690525 0.24898040263229435 1.1538176707837418 0.1471075097820209 0.3468528763875813 1.6557316731087247e-07 6.7810100433544855 -1.1814979673352384 PK(ub)RPANQFVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PKRPANQFVPR 11 2 Q5SRQ6;P67870 Q5SRQ6 CSNK2B Casein kinase II subunit beta 1 17455600.0 7447000.0 6288100.0 3720500.0 True False 9763089.11685058 5349939.99082182 3335538.349556042 1.0 0.5479761504571442 0.3416478442052811 23.218906269205252 -12.452709942311838 0.12307917621337361 2.5086376117809075 5.849717894398443e-22 0.9997290244991337 0.004525863575450125 6.721036508798525 0.09223453286720687 2.8150224352873803 0.270220850823844 3.5260629199190786e-13 12.452709942311838 -2.5086376117809075 PK(ub)RPANQFVPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PKRPANQFVPR 11 2 Q5SRQ6;P67870 Q5SRQ6 CSNK2B Casein kinase II subunit beta 1 22742900.0 7781000.0 10657000.0 4304900.0 True False 7533996.414104071 14912395.675520811 3177317.5457682656 1.0 1.97934732854451 0.4217306952549308 22.84498391594164 -6.736759930274953 1.6987249929583066 1.5848883971104715 0.42147667913217085 0.590245520021178 0.41152265577769387 0.32370655338741927 1.832862866813846 0.1917545403761174 0.47220220803396856 1.8333275709140884e-07 6.736759930274953 -1.1634117179783006 PK(ub)RPANQFVPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PKRPANQFVPR 11 2 Q5SRQ6;P67870 Q5SRQ6 CSNK2B Casein kinase II subunit beta 1 20639300.0 5601000.0 10091000.0 4947300.0 True False 8497126.487948727 8290182.20865714 3969463.986521381 1.0 0.9756453808725701 0.4671536892090729 23.018543610283242 -6.916881447379262 0.8475307195543106 1.0125295033083619 0.39076048466237123 0.9932699227926405 0.020152155734333516 0.10004180720646351 0.11537815577014741 0.0170822634862929 0.04973891668819978 1.2109286447081532e-07 6.916881447379262 -0.6217690186459907 down PK(ub)RPANQFVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PKRPANQFVPR 11 2 Q5SRQ6;P67870 Q5SRQ6 CSNK2B Casein kinase II subunit beta 1 15857000.0 7447000.0 5669700.0 2740300.0 True False 10200357.14760792 5419193.906809339 2093097.5782500424 1.0 0.5312749179650235 0.2051984600108726 23.282116330728144 -8.186947139009437 0.28853617019814165 1.1532517159425513 9.838393749784772e-14 0.9991474445125968 0.009524966922883649 0.0904727493373505 0.06398300799757183 0.08034304808441972 0.09620266919975724 6.502088269484021e-09 8.186947139009437 -1.153251715942453 down PK(ub)RPANQFVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PKRPANQFVPR 11 2 Q5SRQ6;P67870 Q5SRQ6 CSNK2B Casein kinase II subunit beta 1 25336400.0 7781000.0 15167000.0 2388400.0 True False 6470246.256746272 15085292.360586224 2887803.397286123 1.0 2.331486586751993 0.4463204772577433 22.625389191375916 -6.716937379413126 1.7702714441372374 1.81269462902533 0.4497394353325535 0.4980546796627553 0.5605149333640772 0.361302635625604 2.2111122293857766 0.2515675950629848 0.6338303199982158 1.9189454119843757e-07 6.716937379413126 -1.3629551936927766 PK(ub)RPANQFVPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PKRPANQFVPR 11 2 Q5SRQ6;P67870 Q5SRQ6 CSNK2B Casein kinase II subunit beta 1 20269500.0 5601000.0 10781000.0 3887500.0 True False 7250604.91221594 10181027.872739354 3180014.889118444 1.0 1.4041625486428297 0.4385861493791645 22.78966993237569 -6.793001928750014 1.48420024669974 1.225012075443129 0.42743519288660564 0.8109204361173893 0.17216491089259028 0.2309162127157129 1.004787785654541 0.09128651052212247 0.21327718770212112 1.6106384821380575e-07 6.793001928750014 -0.7975768825565235 down PK(ub)VQVEYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PKVQVEYK 8 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 13636300.0 3200900.0 6803400.0 3632000.0 True False 4196410.897559689 5788359.239445492 3256195.480604103 1.0 1.3793595004749315 0.7759477229690869 22.000724517698913 -6.7367586253546 1.6985674323162907 1.2265599941897904 0.7758381132412278 0.590310160589025 0.15940743788586284 0.3237087361680569 1.8325046467349304 0.07428240771445978 0.18293470821195768 1.833333079503663e-07 6.7367586253546 -0.4507218809485627 PK(ub)VQVEYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PKVQVEYK 8 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 26704100.0 6936000.0 11246400.0 8521700.0 True False 6715820.476574445 15737146.169201227 6289611.124479884 1.0 2.3432946464388387 0.9365365179755433 22.679132234825826 -6.656617865014958 1.984881281712397 1.867038647975196 0.942420221726153 0.22141786100371885 0.5724053005080139 0.49245428449905254 3.7259858308842637 0.2332816266035486 0.6343356151288061 2.2048656673737299e-07 6.656617865014958 -0.9246184262490429 PK(ub)VQVEYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PKVQVEYK 8 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 32061700.0 15419100.0 12613200.0 4029400.0 True False 23391901.987204086 10362275.912618596 3232987.3238512427 1.0 0.4429856075101119 0.13820968152225338 24.479505835690155 -8.685771832815659 0.3054465534505258 1.195388037616364 2.0779690232396656e-24 0.9986074502066774 0.013315126393587609 0.2639126072611157 0.09315428899343417 0.15117513808854424 0.09556979605261783 2.0617127998219754e-09 8.685771832815659 -1.195388037616364 PK(ub)VQVEYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PKVQVEYK 8 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 16764000.0 3200900.0 7012600.0 6550500.0 True False 4384359.231069986 6702760.144432894 5003406.811782244 1.0 1.528788995421142 1.1411945390617961 22.063934579221804 -10.50640846300264 10.293998131182995 0.9999972202625741 1.334991767241469 0.49899370848309477 0.1582347742019733 1.0094909324433402e-05 4.839333491578535e-07 0.15321143229944148 0.0510700537729278 3.115957582522351e-11 10.50640846300264 0.33499454697889497 PK(ub)VQVEYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PKVQVEYK 8 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 23877300.0 6936000.0 14061900.0 2879400.0 True False 5767591.316899123 13986145.753631385 3481469.227158625 1.0 2.424954367458697 0.6036261995467452 22.459537510260102 -6.697982331491961 1.8379293150754017 1.88657959398027 0.6092233688966557 0.4080563002916645 0.6017158233534752 0.3997413550264293 2.6237528863046093 0.2613161094644654 0.6737488151302876 2.0045535774470414e-07 6.697982331491961 -1.2773562250836143 PKPGDGEFVEVISLPK(ub)NDLLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PKPGDGEFVEVISLPKNDLLQR 22 2 A6NFX8;Q9UKK9;A6NJU6 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 1 9134900.0 2205700.0 3138500.0 3790700.0 True False 2891694.060029188 2670248.0337771843 3398474.7269619917 1.0 0.9234199671006107 1.1752539018348602 21.463483493180743 -6.825128369231018 1.3496301113911846 0.9589242635402289 1.1813762025818295 0.8957556772963712 0.034033158620576286 0.18690157670023888 0.6675151802449876 0.019808798477342907 0.045603788989031675 1.4957934625019003e-07 6.825128369231018 0.22245193904160065 PKPGDGEFVEVISLPK(ub)NDLLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PKPGDGEFVEVISLPKNDLLQR 22 2 A6NFX8;Q9UKK9;A6NJU6 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 1 34941800.0 7638800.0 13393000.0 13910000.0 True False 7396310.475267719 18740894.743572317 10266553.708944818 1.0 2.5338166652467313 1.3880641900140362 22.818374355414 -10.445329233462791 5.082113380097778 0.9985418683370713 1.960940427630426 0.4839737763519073 0.4677514893086342 0.007737284967938892 0.0008444597061944443 0.45345212552263287 0.150966144021317 3.5864994332032314e-11 10.445329233462791 0.9623985592933548 PKPGDGEFVEVISLPK(ub)NDLLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PKPGDGEFVEVISLPKNDLLQR 22 2 A6NFX8;Q9UKK9;A6NJU6 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 1 24429300.0 7638800.0 8323500.0 8467000.0 True False 6352000.656218143 8278659.653414604 10237410.553015247 1.0 1.3033153019766148 1.6116828550692248 22.598779630848277 -6.970919364935859 0.2351936477983442 0.882459354546203 2.0414053533813594 0.999988691538097 0.0008397444186588396 0.0760054964694788 0.007954835418707966 0.007628819557674534 0.030326525693516484 1.0692533881042799e-07 6.970919364935859 1.1589459988351565 PLADTMRPDTLQDYFGQSK(ub)AVGQDTLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PLADTMRPDTLQDYFGQSKAVGQDTLLR 28 2 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 31347200.0 9304100.0 8691100.0 13352000.0 True False 9008746.438306862 12161501.553487746 9854710.648586001 1.0 1.3499660176664294 1.0939047642280109 23.10289493917446 -10.349782921174059 4.406249022658329 0.9996971637189072 1.2219353909483952 0.5004053275444018 0.10453656897428637 0.0003114118935107879 4.5954032052760756e-05 0.10135424382851023 0.03373903255836097 4.4690691938992375e-11 10.349782921174059 0.22223822722948805 PLADTMRPDTLQDYFGQSK(ub)AVGQDTLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PLADTMRPDTLQDYFGQSKAVGQDTLLR 28 2 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 32321100.0 9304100.0 11824000.0 11193000.0 True False 7736771.3915169 11760301.765119758 13533404.549415307 1.0 1.5200528967437914 1.7492315417583895 22.883300214608735 -10.92816576767906 0.15916925310033078 1.0378115121273487e-17 2.0285994053494556 0.9996008994763241 0.00626218437208722 3.05555305750573 0.09083381188990816 1.3266167985272512 0.19734243948641658 1.1798702000964406e-11 10.92816576767906 2.0285994053494556 PLADTMRPDTLQDYFGQSK(ub)AVGQDTLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PLADTMRPDTLQDYFGQSKAVGQDTLLR 28 2 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 23800800.0 4265500.0 7115300.0 12420000.0 True False 5521773.835575267 6719327.300148612 10159687.439961685 1.0 1.21687839818028 1.839931830330612 22.396700367613064 -6.95242044095071 0.5316098124162878 0.9902856774761762 2.094886634862786 0.9993777842774965 0.008880515114275404 0.08252817820302447 0.03205110468335673 0.00988417789948295 0.05153410084042933 1.1157825344845202e-07 6.95242044095071 1.10460095738661 PLESSQVK(ub)YLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PLESSQVKYLR 11 1 Q92734-2;Q92734;Q92734-4;Q92734-3;C9JJP5;C9JTY3;C9JUE0 Q92734-2 TFG Protein TFG 1 48314000.0 14850000.0 22006000.0 11458000.0 True False 19468493.80760458 18722790.578716148 10272436.072896967 1.0 0.961696922409213 0.5276441092163203 24.21463793756845 -6.924237883081324 0.792669905114068 1.008195315539183 0.4503412062861051 0.9952792096300529 0.014718221771697465 0.09574232767772105 0.0931627730455551 0.012974640647477848 0.04058954151302764 1.1905896886074479e-07 6.924237883081324 -0.5578541092530779 PLESSQVK(ub)YLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PLESSQVKYLR 11 1 Q92734-2;Q92734;Q92734-4;Q92734-3;C9JJP5;C9JTY3;C9JUE0 Q92734-2 TFG Protein TFG 1 67796000.0 24577000.0 19435000.0 23784000.0 True False 23796816.587769635 27195496.85218612 17554256.89529429 1.0 1.1428207950370655 0.7376724878535348 24.50426525454235 -6.811425340132944 1.4084146466948537 1.0777066522525427 0.7303429897153801 0.8635429575633327 0.06197900391172306 0.20486432411579836 0.8006386940602371 0.03459868224207914 0.07998788551957615 1.5437417862408666e-07 6.811425340132944 -0.34736366253716255 PLESSQVK(ub)YLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PLESSQVKYLR 11 1 Q92734-2;Q92734;Q92734-4;Q92734-3;C9JJP5;C9JTY3;C9JUE0 Q92734-2 TFG Protein TFG 1 50189000.0 24031000.0 14994000.0 11164000.0 True False 36456783.90142759 12318203.551343296 8957430.506644972 1.0 0.337885085657842 0.24569996439796252 25.119683961350745 -13.999999999999998 0.2777755930764284 6.330623283840763 0.21733445835081386 0.9996002661822401 0.006717096061694467 15.279270630673617 0.16692609920102455 46.20853699126461 0.036855471729486396 1.0000000000000041e-14 13.999999999999998 -6.113288825489949 PLESSQVK(ub)YLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PLESSQVKYLR 11 1 Q92734-2;Q92734;Q92734-4;Q92734-3;C9JJP5;C9JTY3;C9JUE0 Q92734-2 TFG Protein TFG 1 45538000.0 14850000.0 12687000.0 18001000.0 True False 20340446.306160584 12126446.389701415 13749534.542232238 1.0 0.5961740567132312 0.6759701500781655 24.277847999091343 -10.07320076432551 5.159581506223851 1.0000060133845483 0.6360721033948483 0.9651975318507899 0.03257661870491532 45231946.68325357 3.3829236436739767 3231.4560126165507 0.011151843069498733 8.448881825437797e-11 10.07320076432551 -0.3639339099897 PLESSQVK(ub)YLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PLESSQVKYLR 11 1 Q92734-2;Q92734;Q92734-4;Q92734-3;C9JJP5;C9JTY3;C9JUE0 Q92734-2 TFG Protein TFG 1 67322000.0 24577000.0 30060000.0 12685000.0 True False 20436864.44570787 29898060.813557144 15337374.851186763 1.0 1.4629475521053479 0.7504759300004998 24.284670529976626 -6.73128877568013 1.7182045205890353 1.2781879445724598 0.7507707919579156 0.5654203209872776 0.19459266187707994 0.3338040100181819 1.931135641698568 0.08972162925082634 0.22234178101212662 1.856569554711756e-07 6.73128877568013 -0.5274171526145441 PLESSQVK(ub)YLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PLESSQVKYLR 11 1 Q92734-2;Q92734;Q92734-4;Q92734-3;C9JJP5;C9JTY3;C9JUE0 Q92734-2 TFG Protein TFG 1 45540400.0 24031000.0 13458000.0 8051400.0 True False 31108603.22182848 12709050.469467226 6586127.814340382 1.0 0.4085381262167843 0.2117140318829547 24.890810283443194 -13.99999999996825 0.15373853342688362 3.877684577134881 0.004207249712907388 0.99955424453919 0.007072604551477559 11.973738908242973 0.12366587835027558 10.28369045470529 0.18774924241757354 1.0000000000731085e-14 13.99999999996825 -3.873477327421974 PLFINKPLIVVANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PLFINKPLIVVANK 14 1 Q9BZE4;Q9BZE4-2;Q9BZE4-3 Q9BZE4 GTPBP4 Nucleolar GTP-binding protein 1 0 6080600.0 1683400.0 1511400.0 2885800.0 False True 1629961.3884465746 2114909.901846879 2129922.4078557133 1.0 1.2975214731083182 1.306731817669389 20.636406358715234 -11.961732718467852 0.5347351047296937 3.242990186287653e-13 1.3060157507626933 0.9999289571444315 0.0012008513680176627 6.635975286261156 0.26491396935935324 7.590954610124583 0.0017642122530833406 1.0921122575630595e-12 11.961732718467852 1.3060157507623689 PLFLVHPIEGSTTVFHSLASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PLFLVHPIEGSTTVFHSLASR 21 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 5508700.0 1970200.0 1271700.0 2266800.0 False True 2582951.2794439415 1081967.3170477743 2032253.2806809952 1.0 0.4188880083253837 0.7867950498541727 21.300589000403967 -10.19291353449683 7.157884450995036 1.0000006636394099 0.6028415290898063 0.6084239585804809 0.15019742075374562 1.5907028241113441e-06 1.7922835140691338e-07 0.14542827216454374 0.04847600910188043 6.413372503882932e-11 10.19291353449683 -0.3971591345496036 PLFLVHPIEGSTTVFHSLASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PLFLVHPIEGSTTVFHSLASR 21 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 9168800.0 2419700.0 1718000.0 5031100.0 False True 2342887.947976814 2404006.3592516463 3713303.9802352525 1.0 1.0260867837608754 1.5849259813905536 21.159856526186832 -6.9166442058091056 0.8492354847504626 0.9861162303947792 1.6684392712322105 0.9931970005829532 0.022253044375234437 0.1001868816960747 0.11614042118915076 0.018840045529251233 0.054745495568845566 1.2115903180797032e-07 6.9166442058091056 0.6823230408374312 PLFLVHPIEGSTTVFHSLASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PLFLVHPIEGSTTVFHSLASR 21 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 8224900.0 1970200.0 1740500.0 4514200.0 False True 2698636.1826530346 1663598.9549361786 3448038.932867331 1.0 0.6164591454119952 1.2776968436988632 21.36379906192686 -6.7494067190146225 1.6517388665880621 0.7743243738992309 1.2789796119429613 0.6465987659440826 0.16116203279071992 0.3010493937042833 1.6157425952606503 0.07707882890114152 0.1872654112228269 1.78071034193723e-07 6.7494067190146225 0.5046552380437304 PLFPHVLCHNCAVEFNFGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PLFPHVLCHNCAVEFNFGQK 20 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 110273300.0 86623800.0 19751000.0 3898500.0 False True 83873974.88447088 27637677.300104335 2877365.8975069285 1.0 0.32951433788815704 0.03430582491732686 26.321719892879017 -8.825521141386067 0.4180632512892566 1.1223523055193918 1.1575421874103899e-24 0.9966936633255749 0.023232836523727346 0.37097793562189346 0.1531522192335298 0.1480959583228685 0.06899772584655213 1.4944412914321603e-09 8.825521141386067 -1.1223523055193918 PLFPHVLCHNCAVEFNFGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PLFPHVLCHNCAVEFNFGQK 20 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 996442000.0 184880000.0 361473000.0 450089000.0 False True 280476476.53846794 296965318.94856036 361128711.8689829 1.0 1.0587886820798353 1.2875543657917186 28.063304536690875 -6.945508380970401 0.60616011843439 0.9974542217809995 1.3607238335819407 0.9987999291678386 0.004297057670024466 0.08534119867864844 0.043825371615307425 0.004383888535955695 0.01926442230871918 1.133682960196737e-07 6.945508380970401 0.3632696118009412 PLFPHVLCHNCAVEFNFGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PLFPHVLCHNCAVEFNFGQK 20 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 255856900.0 38486000.0 67155600.0 150215300.0 False True 52715314.24504343 64188443.53812805 114737539.9212143 1.0 1.2176431926356843 2.1765504306370045 25.651718802086407 -6.94266227573177 0.6343227073229689 0.9895324579301307 2.4567243818782156 0.9984921183645253 0.019847318314361772 0.086573005406553 0.04923639985005047 0.019734371332289613 0.0816126349000244 1.1411368349690007e-07 6.94266227573177 1.4671919239480848 up PLFPHVLCHNCAVEFNFGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PLFPHVLCHNCAVEFNFGQK 20 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 216493000.0 86623800.0 1657200.0 128212000.0 False True 72031527.78500675 1648272.3346715565 155020536.41469115 1.0 0.02288265132444743 2.1521206224777374 26.102125168313293 -6.781914002196494 1.5282548752569733 0.44810857576526997 2.170058369562332 0.7741541884796035 0.4135642712053958 0.24761281566766147 1.1423686258748322 0.2131065184187023 0.5020768653699733 1.6522889475680966e-07 6.781914002196494 1.7219497937970618 PLFPHVLCHNCAVEFNFGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PLFPHVLCHNCAVEFNFGQK 20 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 665719000.0 184880000.0 289904000.0 190935000.0 False True 239330804.52963424 273770587.55390304 156186789.15854162 1.0 1.143900335320205 0.652597936423192 27.834430858783325 -6.828289077440882 1.3354599442737625 1.076988305797025 0.6398265021986924 0.9024206632406325 0.0644211737258568 0.182934500184847 0.6386583538839351 0.03788099844546209 0.08718649951612312 1.484946894875882e-07 6.828289077440882 -0.4371618035983327 PLHISTFINELDSGFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PLHISTFINELDSGFR 16 0 E9PGT1;Q15631 E9PGT1 TSN Translin 0 20424730.0 12630330.0 3196600.0 4597800.0 False True 12229387.087643102 4473019.050048787 3393498.2489566165 1.0 0.36575987152851225 0.27748718923007165 23.543848764906294 -13.999999999999998 0.2778266345263371 6.107634380529471 0.25033915017960234 0.9996003785869962 0.006433227764597697 15.281917465563806 0.1669415121911105 44.29270814478309 0.03528250832399108 1.0000000000000041e-14 13.999999999999998 -5.857295230349869 PLHISTFINELDSGFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PLHISTFINELDSGFR 16 0 E9PGT1;Q15631 E9PGT1 TSN Translin 0 63052000.0 15947000.0 28707000.0 18398000.0 False True 24192764.88186363 23584011.561185244 14761627.235870147 1.0 0.9748373811901613 0.6101670192701439 24.52807232205393 -6.920852386136509 0.8183947235611163 1.0078018226359207 0.5501949539494353 0.99441408443389 0.013313596686141497 0.09767294797985596 0.10303934710660516 0.01152306061955438 0.03480259993707593 1.1999070744391703e-07 6.920852386136509 -0.45760686868648537 PLHISTFINELDSGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PLHISTFINELDSGFR 16 0 E9PGT1;Q15631 E9PGT1 TSN Translin 0 20597230.0 12630330.0 3716500.0 4250400.0 False True 10502679.013490561 3696478.4768325053 5139138.988370848 1.0 0.35195576976925835 0.4893169620598409 23.32425404034057 -9.931120943886473 6.969561968339861 1.0000000205746569 0.4206363659167226 0.959546783175168 0.0560774719287165 1.792332683326448e-08 2.7861209873169966e-09 0.05429678114657874 0.018098926239776526 1.171868973823935e-10 9.931120943886473 -0.5793636546579343 PLHISTFINELDSGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PLHISTFINELDSGFR 16 0 E9PGT1;Q15631 E9PGT1 TSN Translin 0 44975000.0 15947000.0 18336000.0 10692000.0 False True 20643705.862365197 17315585.481360607 8746165.709184408 1.0 0.8387828036693756 0.4236722692861668 24.29919864414638 -6.954826384138095 0.5030776854852173 1.0080961577444552 0.23636089253129866 0.9995276203041757 0.005276561293677074 0.08160367437331131 0.028375303768233353 0.0061528093318285555 0.03424694868900555 1.1096183135019139e-07 6.954826384138095 -0.7717352652131565 down PLISVYSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PLISVYSEK 9 0 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 338201000.0 97285000.0 77576000.0 163340000.0 False True 127541577.10928024 66001963.188879624 146439143.6679168 1.0 0.5174937042869384 1.1481678914981954 26.926392385096026 -6.702248547853823 1.822675728527835 0.7010465934314419 1.1463832244751115 0.4283086643302446 0.20358938303461385 0.39087812079237727 2.5260663328211015 0.08905459360252893 0.2284062426743315 1.9849585952969105e-07 6.702248547853823 0.4453366310436696 PLISVYSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PLISVYSEK 9 0 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 181304000.0 53084000.0 34233000.0 93987000.0 False True 51398877.47671248 47902415.422736675 69368985.15043825 1.0 0.9319739608017712 1.3496206251171061 25.615233516306485 -6.865132520625455 1.1596251081026263 0.9624596657441898 1.3719109114736354 0.9595740588116983 0.03678762818627672 0.14160231398929812 0.3589751483495985 0.024687364874049485 0.05799928152435991 1.3641668111898558e-07 6.865132520625455 0.4094512457294456 PLISVYSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PLISVYSEK 9 0 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 351489000.0 97285000.0 98104000.0 156100000.0 False True 133253893.52827154 93769440.89345522 119232394.9804151 1.0 0.7036900642123513 0.8947760686266057 26.989602446618917 -10.698795750996968 5.908123429155871 1.0033353414850676 0.7992330664194791 0.5954457028988622 0.07801053463368958 0.003477054422148038 0.0001772647898921247 0.07663117361789686 0.025177791788751402 2.0008026272913714e-11 10.698795750996968 -0.20410227506558853 PLISVYSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PLISVYSEK 9 0 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 119913000.0 53084000.0 40724000.0 26105000.0 False True 44141698.01993555 40504611.728918925 31563434.804117475 1.0 0.9176042958434898 0.715048043459103 25.39563879174076 -6.95582079840575 0.49080099150792517 1.0044007805743835 0.6196505788991065 0.9995824315630921 0.0024465982367884317 0.08122919745485552 0.026915243063644147 0.002921427751941758 0.016706252777747097 1.1070805009611436e-07 6.95582079840575 -0.38475020167527707 PLISVYSEK(ub)GESSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PLISVYSEKGESSGK 15 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 20865700.0 3149300.0 8654000.0 9062400.0 True False 4128762.7978645824 7362856.933027792 8124709.78067914 1.0 1.7833082919745111 1.9678315704843308 21.977278105742247 -10.94709237100684 0.27783915784026264 2.501759059346838e-10 2.036600141199534 0.99921072557586 0.011787290262976598 2.822488587610583 0.1436965647448415 1.8946143244209175 0.0732936595496858 1.1295556415563228e-11 10.94709237100684 2.036600140949358 PLISVYSEK(ub)GESSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PLISVYSEKGESSGK 15 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 25162900.0 6507200.0 5630700.0 13025000.0 True False 6300632.497861198 7879067.873712601 9613361.758375723 1.0 1.250520146411843 1.525777255162725 22.587065232178762 -6.96991500968357 0.2602070506830881 0.9229164407909257 1.8615496436239232 0.9999817119633676 0.0009182507463041386 0.07633027900049506 0.009128722414630246 0.0057383835098923554 0.025962881534710863 1.0717290193374891e-07 6.96991500968357 0.9386332028329974 PLISVYSEK(ub)GESSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PLISVYSEKGESSGK 15 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 40600200.0 12493000.0 8215200.0 19892000.0 True False 18952794.360639784 6749133.37434944 15960337.481026683 1.0 0.35610228475679045 0.8421099906076285 24.175907236250726 -9.935483809769016 6.617980756445516 1.0000000361477894 0.5991061376823067 0.47567584933998863 0.19841181506589406 1.0574270180106539e-07 1.7302459773894156e-08 0.19211143103627737 0.06403713795341238 1.1601554652235856e-10 9.935483809769016 -0.40089389846548273 PLISVYSEK(ub)GESSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PLISVYSEKGESSGK 15 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 21581000.0 3149300.0 6621700.0 11810000.0 True False 4313681.316632422 6329131.398966328 9020721.234584901 1.0 1.46722275810289 2.0911886095533694 22.04048816726514 -6.9671158290969 0.3196625546226355 0.9142089428747613 2.6643181407005794 0.9999503521457898 0.0031496486871291102 0.07725011714052575 0.01236585284332033 0.009471061326337037 0.054901870423422414 1.0786589986562523e-07 6.9671158290969 1.750109197825818 PLISVYSEK(ub)GESSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PLISVYSEKGESSGK 15 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 27666200.0 6507200.0 10539000.0 10620000.0 True False 5411025.117838236 10482224.315172277 12840592.89866797 1.0 1.9371974971278718 2.373042560149477 22.36747050761304 -9.745140143192856 0.19874614082746078 5.717239749419247e-23 2.7831773171488505 0.9994540498728621 0.013385267528878116 1.203225986531384 0.08530482753326592 0.9424551041343052 0.2594300143317475 1.7982905281949014e-10 9.745140143192856 2.7831773171488505 PLISVYSEK(ub)GESSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PLISVYSEKGESSGK 15 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 56370000.0 12493000.0 10127000.0 33750000.0 True False 16172434.773846406 9563423.547651539 27607846.304243755 1.0 0.5913409873890622 1.7070927593963998 23.947033558343175 -6.807575227659794 1.424634697975129 0.7766327057981885 1.7255587732712239 0.8534047977832717 0.17646941076355876 0.21013512592512743 0.8410015222770753 0.09741037694698132 0.22559485003609853 1.5574882263317377e-07 6.807575227659794 0.9489260674730353 PLISVYSEKGESSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PLISVYSEKGESSGK 15 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 12021300.0 3384900.0 2564000.0 6072400.0 False True 4437636.679418228 2181461.1943937186 5444086.298573883 1.0 0.4915817476701827 1.226798562357205 22.081360124588215 -6.7206613807486795 1.7567926673794143 0.6909064215576997 1.2257065323125844 0.5157001496883555 0.21392696625683028 0.35403484680345326 2.135750554355566 0.09667179994461449 0.24250687516583078 1.9025611279872506e-07 6.7206613807486795 0.5348001107548848 PLISVYSEKGESSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PLISVYSEKGESSGK 15 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 36816300.0 5936800.0 22180000.0 8699500.0 False True 9006559.638217099 18221805.706869036 6980040.011873689 1.0 2.0231704933756647 0.774995147120952 23.10254469414981 -6.688937572439437 1.8712185042797713 1.6421362913948467 0.7794803829157891 0.3650581732866982 0.43282716617757744 0.4189184153386166 2.8433464871183167 0.18514461734335283 0.48259343577893576 2.0467388235824056e-07 6.688937572439437 -0.8626559084790576 PLISVYSEKGESSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PLISVYSEKGESSGK 15 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 12052100.0 3384900.0 6930600.0 1736600.0 False True 4636389.003483023 6624383.17557063 1326450.8463996714 1.0 1.428780710719949 0.28609567605375513 22.144570186111107 -6.8050438412466 1.4350822916046144 1.2350828988911189 0.2682570634176268 0.8465528992928351 0.18462508304349481 0.21362686907700593 0.8679554058411733 0.10118287337807497 0.2346451213045859 1.5665929173891467e-07 6.8050438412466 -0.9668258354734921 down PLISVYSEKGESSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PLISVYSEKGESSGK 15 1 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 19748600.0 5936800.0 8224700.0 5587100.0 False True 7685304.631823525 7766988.214907639 4570305.128487116 1.0 1.0106285420028605 0.594681063072278 22.87367101624226 -6.901035467369068 0.9546842486218731 1.016805677553372 0.5500882601351083 0.9870748610940747 0.022012759359372566 0.11064758613111551 0.17314625779038062 0.01725885502462947 0.045143146199198333 1.2559273921422925e-07 6.901035467369068 -0.4667174174182638 PLLGLILLNEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PLLGLILLNEK 11 0 E7ESC6;Q9UIA9;Q9H2T7 E7ESC6 XPO7;RANBP17 Exportin-7;Ran-binding protein 17 0 5809600.0 0.0 1831300.0 3978300.0 False True 0.0 1750387.110700731 3038707.47566038 0.0 PLLSLQWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PLLSLQWK 8 0 A0A0C4DFL8;F5GX28;O94953;K7EQ54 A0A0C4DFL8 KDM4B Lysine-specific demethylase 4B 0 125821900.0 34453800.0 26828100.0 64540000.0 False True 45169265.45107382 22825452.055114742 57862019.91139561 1.0 0.5053314865135162 1.2810042256292669 25.42883811686875 -6.734443680038811 1.7071376794178759 0.7037888128490116 1.2809195738254078 0.579669239141007 0.20788459325364905 0.3279816414383375 1.874524557456828 0.09642594287458452 0.2380701209426729 1.8431314935354253e-07 6.734443680038811 0.5771307609763962 PLLSLQWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PLLSLQWK 8 0 A0A0C4DFL8;F5GX28;O94953;K7EQ54 A0A0C4DFL8 KDM4B Lysine-specific demethylase 4B 0 111213100.0 42728000.0 13436100.0 55049000.0 False True 41371623.02812471 18801204.798335876 40630015.46539924 1.0 0.4544468749885565 0.9820744870893433 25.302138220496126 -10.842801162624786 10.490383700175336 1.0063207896721595 0.7182606810389499 0.27545193508773336 0.21540307064167644 0.03181663205527301 0.00047677281947230336 0.20838909888781812 0.06952104210976263 1.4361468082762868e-11 10.842801162624786 -0.28806010863320963 PLLSLQWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PLLSLQWK 8 0 A0A0C4DFL8;F5GX28;O94953;K7EQ54 A0A0C4DFL8 KDM4B Lysine-specific demethylase 4B 0 117708800.0 34453800.0 33084000.0 50171000.0 False True 47192300.93893569 31622239.485842302 38321643.10417945 1.0 0.6700720002349491 0.8120316734241376 25.49204817839164 -10.155810532408967 4.724007082504278 1.0000259953555255 0.7410518368287558 0.8160560290069834 0.057954793902347486 1.6251756864815485e-05 2.9041804457585957e-06 0.05612025226407041 0.018704829300238306 6.98537085068027e-11 10.155810532408967 -0.25897415852676975 PLLSLQWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PLLSLQWK 8 0 A0A0C4DFL8;F5GX28;O94953;K7EQ54 A0A0C4DFL8 KDM4B Lysine-specific demethylase 4B 0 85780100.0 42728000.0 20579200.0 22472900.0 False True 35530225.17134743 20468335.764948606 27171879.48705043 1.0 0.5760823542839477 0.7647539343196337 25.082543495930402 -10.04892256693788 4.88082936710399 1.0000068031273002 0.6704181443422392 0.8027095441255322 0.07702485002322224 6.298682338519268e-06 1.2274161543372314e-06 0.07458069012670275 0.024859663446591213 8.934647709192025e-11 10.04892256693788 -0.32958865878506094 PLPASGK(ub)TLEFAGQDLSAYLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PLPASGKTLEFAGQDLSAYLLK 22 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 101332000.0 16976000.0 21049000.0 63307000.0 True False 16437106.172192585 29453975.46908491 46724997.53070954 1.0 1.7919197674170633 2.8426535085449767 23.970452992518755 -6.967215715298399 0.31773583925903387 0.8522249956749647 3.8161265618362266 0.999951803463725 0.005239610522449794 0.07721692304123512 0.01224975193524301 0.01607580103159347 0.09261219347401005 1.0784109394124573e-07 6.967215715298399 2.9639015661612618 PLPASGK(ub)TLEFAGQDLSAYLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PLPASGKTLEFAGQDLSAYLLK 22 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 132668000.0 10823000.0 19475000.0 102370000.0 True False 16419282.267286051 15999534.091130476 82136524.62963499 1.0 0.974435656241084 5.002443060089457 23.968887728473515 -6.9054715277745125 0.9260368969509127 0.8567306361404798 5.475538478275018 0.9890971410781297 0.19764255191475016 0.10748885334014895 0.15558029382258529 0.15827357210076062 0.4243349770573418 1.2431641346681074e-07 6.9054715277745125 4.618807842134538 up PLPASGK(ub)TLEFAGQDLSAYLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PLPASGKTLEFAGQDLSAYLLK 22 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 92424800.0 16976000.0 22044000.0 53404800.0 True False 14116296.164313652 21925244.596608598 64571496.76410387 1.0 1.553186780824007 4.574252056806673 23.75085826795303 -6.9378575821126995 0.6792003479331141 0.9645048556656327 5.340038322531015 0.9978696355928542 0.07250395146835024 0.0887577190229654 0.059162918428327604 0.06948025375098021 0.26256573605451755 1.1538315709720358e-07 6.9378575821126995 4.375533466865383 up PLPASGK(ub)TLEFAGQDLSAYLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PLPASGKTLEFAGQDLSAYLLK 22 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 80242000.0 10823000.0 15735000.0 53684000.0 True False 14010586.853224995 14859333.417823369 43914062.844356164 1.0 1.0605789445859655 3.134348568293405 23.740014050565964 -6.913143094331734 0.87404733245454 0.941997128284362 3.421188526054083 0.9920548266199349 0.08843788057544533 0.1023763533009899 0.12776105054712217 0.07354981228038765 0.20773947798635173 1.2213971595257733e-07 6.913143094331734 2.479191397769721 up PLPDHVSIVEPK(ub)DEILPTTPISEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PLPDHVSIVEPKDEILPTTPISEQK 25 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 124423800.0 31122000.0 59292800.0 34009000.0 True False 40801243.38587675 50446545.361524224 30490074.91736369 1.0 1.2363972559470129 0.7472829842219404 25.282109782077555 -6.775251482339838 1.554081303962796 1.1346768473562467 0.7439498488357104 0.7503469243582856 0.0997892450978184 0.2580130286435802 1.230395620074779 0.050589415242491546 0.11986661876622161 1.6778321721347584e-07 6.775251482339838 -0.3907269985205364 PLPDHVSIVEPK(ub)DEILPTTPISEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PLPDHVSIVEPKDEILPTTPISEQK 25 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 269190100.0 83951100.0 77694100.0 107544900.0 True False 81286118.28300877 108717759.29937896 79375664.41215666 1.0 1.3374701805893003 0.9764971693665996 26.276505659879152 -6.661346252439403 1.9684061409653113 1.2169872030555615 0.9780071928058495 0.24125165493889678 0.1436415622219758 0.4812399249202438 3.58596613294093 0.0589319209168742 0.15922911809735268 2.1809903678531053e-07 6.661346252439403 -0.23898001024971205 PLPDHVSIVEPK(ub)DEILPTTPISEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PLPDHVSIVEPKDEILPTTPISEQK 25 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 139371500.0 31122000.0 64285000.0 43964500.0 True False 42628644.440426245 61444676.13793293 33580990.57729954 1.0 1.4413940894555581 0.7877564726279099 25.345319843600446 -6.724812437712119 1.7420418121903483 1.2671530233431647 0.7884928942860434 0.5350767267226729 0.1856396667915121 0.3460642312611645 2.0549013256052038 0.08453202957147946 0.2110119135719459 1.884462772025732e-07 6.724812437712119 -0.4786601290571213 PLPDHVSIVEPK(ub)DEILPTTPISEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PLPDHVSIVEPKDEILPTTPISEQK 25 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 212381600.0 83951100.0 104681500.0 23749000.0 True False 69809059.31432092 104117559.98184903 28714806.09703066 1.0 1.4914620108695538 0.4113335200198004 26.05691093531343 -6.782969267911382 1.5241209158185685 1.2771936284777694 0.4019351125782017 0.7778575460142703 0.20811385843290173 0.24596324861468535 1.1286727313312384 0.10752408723662615 0.25310867565918005 1.6482790249780543e-07 6.782969267911382 -0.8752585158995677 down PLPDHVSIVEPK(ub)DEILPTTPISEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PLPDHVSIVEPKDEILPTTPISEQK 25 1 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;E9PSF4 P23396;E9PSF4 RPS3 40S ribosomal protein S3 1 181123500.0 97819900.0 73315000.0 9988600.0 True False 126629788.86850055 69234955.80093545 8170777.291690936 1.0 0.5467509376710159 0.0645249223322636 26.91604158880603 -7.803677989231696 0.5116737081735868 1.019406406480993 1.5818451135453137e-25 0.9944297973040305 0.028507657112522664 0.11188627621947764 0.10866331681171101 0.034585955555761834 0.07731784165389065 1.5715275929004667e-08 7.803677989231696 -1.019406406480993 down PLSHQPGPEAPALPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PLSHQPGPEAPALPK 15 0 P26640;A0A140T936;A0A140T954 P26640 VARS Valine--tRNA ligase 0 6168920.0 2389000.0 489520.0 3290400.0 False True 2313162.5026724865 684987.8888130765 2428545.53011589 1.0 0.2961261424658594 1.0498810729078034 21.141435190060324 -11.928739476948994 18.17531176946921 0.9341456299545077 0.7057032469321645 0.0 0.3525253462578213 0.0 0.0 0.0 0.10237767625683332 1.1783126035872704e-12 11.928739476948994 -0.2284423830223432 PLVVFCGLPYSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PLVVFCGLPYSGK 13 0 Q96EK9 Q96EK9 KTI12 Protein KTI12 homolog 0 7822100.0 2769100.0 3435400.0 1617600.0 False True 3630316.916002546 2922851.7110843183 1450226.269114865 1.0 0.8051230178280856 0.3994764927332443 21.791664066081836 -6.959255666354585 0.4458006431934688 1.013657524117337 0.17497313471053202 0.9997415869728457 0.0040211412323447075 0.07996810078006643 0.02212195259683846 0.005389206756414594 0.033575778972985436 1.0983590521963025e-07 6.959255666354585 -0.8386843894068049 down PLVVFCGLPYSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PLVVFCGLPYSGK 13 0 Q96EK9 Q96EK9 KTI12 Protein KTI12 homolog 0 10713400.0 2769100.0 3287300.0 4657000.0 False True 3792911.102113753 3142056.2163526006 3557112.513925642 1.0 0.8284022830383667 0.9378317651429523 21.854874127604727 -10.424456288080222 5.241659476759815 1.0001124468020062 0.8831170240906568 0.6033558985173076 0.04467439899555229 5.87615656475841e-05 6.452025697105985e-06 0.04329733639984784 0.014418600275965261 3.763082259407916e-11 10.424456288080222 -0.11699542271134933 PLVVFVLGGPGAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PLVVFVLGGPGAGK 14 0 P30085;P30085-3;Q5T0D2;P30085-2;A0A494BXC7;E9PJD2 P30085 CMPK1 UMP-CMP kinase 0 3778900.0 1012200.0 1591200.0 1175500.0 False True 1327004.002158743 1353799.162449021 1053870.536192213 1.0 1.0201922226660116 0.7941728393266319 20.33974129111432 -6.885099949519009 1.0509006002308914 1.0136087125120563 0.7764991051108031 0.9775734871776061 0.015293033339365674 0.12321041727256642 0.24577596900086177 0.011153038197217842 0.02735770269616702 1.3028668991972025e-07 6.885099949519009 -0.2371096074012532 PLVVFVLGGPGAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PLVVFVLGGPGAGK 14 0 P30085;P30085-3;Q5T0D2;P30085-2;A0A494BXC7;E9PJD2 P30085 CMPK1 UMP-CMP kinase 0 3585300.0 2160500.0 0.0 1424800.0 False True 2091916.110097908 0.0 1051602.1369162172 1.0 0.0 0.5026980440754859 20.996393567193724 -9.290941380033582 9.415489374444217 1.0000000000378895 0.25134900780188446 0.7472971290471606 0.20522561711355908 0.0 0.0 0.19870884932389266 0.06623628310796421 5.117509057165738e-10 9.290941380033582 -0.748650992236005 PLVVFVLGGPGAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PLVVFVLGGPGAGK 14 0 P30085;P30085-3;Q5T0D2;P30085-2;A0A494BXC7;E9PJD2 P30085 CMPK1 UMP-CMP kinase 0 6206800.0 1012200.0 2093600.0 3101000.0 False True 1386437.6936764794 2001097.8293906262 2368607.6670997245 1.0 1.4433377269801608 1.7084126303712797 20.40295135263721 -9.653108406616438 0.10743176919483402 2.4135817373229103e-16 2.3965915738105306 0.999924667796135 0.0025365038231069214 1.156088056160235 0.045339567411070265 0.6684522598851428 0.34087233274511025 2.2227549873916643e-10 9.653108406616438 2.39659157381053 PLVVFVLGGPGAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PLVVFVLGGPGAGK 14 0 P30085;P30085-3;Q5T0D2;P30085-2;A0A494BXC7;E9PJD2 P30085 CMPK1 UMP-CMP kinase 0 4515560.0 2160500.0 614260.0 1740800.0 False True 1796551.4763783962 610950.8594589359 2104793.231450207 1.0 0.3400686634877448 1.171574129171731 20.776798842628 -6.695200716193669 1.8477699639595973 0.5883046657435171 1.1689083898200183 0.3949523407848815 0.2788161255087908 0.40558149166498864 2.6886139572980956 0.12053074710150406 0.31184763005536403 2.0174337586654943e-07 6.695200716193669 0.5806037240765012 PLYSVTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PLYSVTVK 8 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 138647000.0 44361000.0 24009000.0 70277000.0 False True 58157700.59253505 20426950.78634899 63005410.18458554 1.0 0.35123381045382895 1.0833545608347648 25.7934668941065 -6.67282572169086 1.9270665197476509 0.5869174340538074 1.0804554458280098 0.2917824284743389 0.27540130667069856 0.4546413410283774 3.2575346287659066 0.11493496905899481 0.30598275760114313 2.1240966711024845e-07 6.67282572169086 0.4935380117742024 PLYSVTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PLYSVTVK 8 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 75530300.0 22770000.0 9361300.0 43399000.0 False True 22047178.81366784 13099315.9085346 32031499.95790776 1.0 0.5941493022415122 1.4528616213721766 24.394090722627976 -6.778173675153401 1.5428199300064616 0.7696488722567406 1.459296568739669 0.7609064155945854 0.17150344924504282 0.25343581566317125 1.191383859084916 0.08756184071169526 0.20694116778214772 1.666580610654171e-07 6.778173675153401 0.6896476964829285 PLYSVTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PLYSVTVK 8 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 58397000.0 16381000.0 24950000.0 17066000.0 False True 24851174.611513644 20497477.56476025 13692897.61970648 1.0 0.8248092046024935 0.5509959924937515 24.566810707796144 -6.964565055589595 0.36543976816346035 1.0221756929877548 0.34416634693477355 0.9999038965392322 0.0018113659345865096 0.07810886199814969 0.015382223903017888 0.003636067968584283 0.0233132610809823 1.0850130068171447e-07 6.964565055589595 -0.6780093460529812 PLYSVTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PLYSVTVK 8 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 106636000.0 44361000.0 30777000.0 31498000.0 False True 60762460.5109487 29417170.37407113 24058821.121672727 1.0 0.4841339558454926 0.3959487637492495 25.856676955629393 -13.999999999999998 0.24851295090063505 4.560895134672024 0.35998592931944295 0.9995399163896443 0.005714390858449722 13.939505041488966 0.1577483760230781 24.756878240713323 0.04103611816754948 1.0000000000000041e-14 13.999999999999998 -4.200909205352581 PLYSVTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PLYSVTVK 8 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 49371000.0 22770000.0 13541000.0 13060000.0 False True 18934263.882034753 13468051.945321936 15790785.617382662 1.0 0.711305812004697 0.8339793781138388 24.174495998062252 -10.089732001396744 4.6591633528075445 1.0000130503377456 0.7726425950542921 0.8207849669613754 0.050081273666194435 69650907.70299813 2.575152811599014 9751.536367313689 0.01714415205717352 8.133322602076746e-11 10.089732001396744 -0.22737045528345345 PLYSVTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PLYSVTVK 8 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 63608000.0 16381000.0 30395000.0 16832000.0 False True 21205527.417784173 28703491.530647624 13768748.710904624 1.0 1.35358536315278 0.6492999886132217 24.337937029888593 -6.770237907135833 1.5738532248108372 1.2027483753167207 0.645332025032991 0.7313574697138734 0.14902586244865001 0.26604569000041906 1.3006398818232432 0.07463921867601021 0.1776110869932857 1.6973136069331921e-07 6.770237907135833 -0.5574163502837297 PLYVALAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PLYVALAQR 9 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;Q4VXU2;H0YB86;A0A6I8PS38;A0A6I8PLA1;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC1L;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 4 0 30255000.0 13956000.0 0.0 16299000.0 False True 18296451.150096267 0.0 14612535.83104797 1.0 0.0 0.7986541057155276 24.125060509187335 -9.80055901713715 9.744689844786102 1.000018360816594 0.3993270528577735 0.42994572254230645 0.326049173502635 0.0 0.0 0.31569575467723454 0.10523191822574482 1.582854454864491e-10 9.80055901713715 -0.6006913079588205 PLYVALAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PLYVALAQR 9 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;Q4VXU2;H0YB86;A0A6I8PS38;A0A6I8PLA1;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC1L;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 4 0 25933400.0 10728000.0 4874400.0 10331000.0 False True 10387445.512210296 6820773.339660197 7625001.176643355 1.0 0.6566362568778313 0.7340593187882692 23.308337573508464 -9.96779706624763 5.610139593671029 1.0000004931758346 0.6953477878327301 0.9537991239608713 0.0316078326685494 1.9496882707956888e-07 3.588879790274093e-08 0.030604201862090247 0.010201384127751838 1.076968333471843e-10 9.96779706624763 -0.3046527053431045 PLYVALAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PLYVALAQR 9 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;Q4VXU2;H0YB86;A0A6I8PS38;A0A6I8PLA1;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC1L;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 4 0 27133000.0 9675400.0 8699700.0 8757900.0 False True 14678289.166487973 7147170.5639336575 7026897.226276074 1.0 0.486921226504474 0.47872726491307954 23.807180488328655 PLYVALAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PLYVALAQR 9 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;Q4VXU2;H0YB86;A0A6I8PS38;A0A6I8PLA1;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC1L;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 4 0 42367000.0 13956000.0 13193000.0 15218000.0 False True 19115910.346719 12610089.63658317 11623821.824548095 1.0 0.6596646148608627 0.60807053463416 24.188270570710227 -13.999999999999998 0.2656123184605097 3.5660418232756688 0.5902029054632609 0.9995739831033481 0.003588846905110132 14.672514751183003 0.16311382816285136 20.276990709875474 0.021908466886881802 1.0000000000000041e-14 13.999999999999998 -2.975838917812408 PLYVALAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PLYVALAQR 9 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;Q4VXU2;H0YB86;A0A6I8PS38;A0A6I8PLA1;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC1L;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 4 0 16605400.0 10728000.0 5877400.0 0.0 False True 8920807.330982376 5845737.279627441 0.0 1.0 0.6552924037855773 0.0 23.08874284894274 -7.522558626938825 0.7063547070037333 0.993802423954874 5.746189743042878e-17 0.9870654129043022 0.047170770592924544 0.11978968687189126 0.14327283325982018 0.04186483839709182 0.07597227425400031 3.002212114337754e-08 7.522558626938825 -0.9938024239548738 down PMCVESFSDYPPLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PMCVESFSDYPPLGR 15 0 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 24037800.0 5112700.0 9007500.0 9917600.0 False True 6702799.211457227 7663616.1109600095 8891421.888336793 1.0 1.1433456186275786 1.3265236817982715 22.67633228655335 -6.967783494245398 0.30654245781432843 0.9706025247039195 1.505060482347542 0.9999595646299785 0.0008497364291188782 0.07702867738288381 0.011591139724156955 0.0029446753384265697 0.01631815262915429 1.077001990001288e-07 6.967783494245398 0.5344579576436225 PMCVESFSDYPPLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PMCVESFSDYPPLGR 15 0 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 20566800.0 5112700.0 7742600.0 7711500.0 False True 7003003.355522363 7400506.330645709 5890202.523327811 1.0 1.0567617856144373 0.8410966301598256 22.73954234807624 -6.8367569995298725 1.2974563665052066 1.0302193336405456 0.8344503712924796 0.9187176189576375 0.026023170371986287 0.17262228398409146 0.5658856402121345 0.015735647403514193 0.03622478384679211 1.456273680399403e-07 6.8367569995298725 -0.19576896234806607 PMFIVNTNVPR ddPTM_RPMI8226_Bortezomib_1h_R1 2 PMFIVNTNVPR 11 0 P14174 P14174 MIF Macrophage migration inhibitory factor 0 1664196800.0 538037700.0 555255000.0 570904100.0 False True 705372635.0644988 472413118.36703783 511832420.2308239 1.0 0.6697355339335509 0.7256198990254594 29.393810366586155 -10.540274255264274 6.290946475024839 1.0003875788822747 0.6976777164795112 0.9750131175462466 0.02281469651243004 0.00012417530546727728 9.074381270837378e-06 0.022117855826024452 0.0073634116367848335 2.8822108234651215e-11 10.540274255264274 -0.30270986240276354 PMFIVNTNVPR ddPTM_RPMI8226_Bortezomib_2h_R1 2 PMFIVNTNVPR 11 0 P14174 P14174 MIF Macrophage migration inhibitory factor 0 1406146500.0 491113300.0 285313000.0 629720200.0 False True 475523177.11332965 399239968.7876393 464777588.4189412 1.0 0.8395804621159191 0.9774025973673466 28.824940419199613 -10.168160383446352 5.809257076901005 1.0000013461427595 0.9084915297483923 0.37019442558595606 0.05626565110448407 9.809518020566829e-07 1.4058508845588823e-07 0.05447978366282956 0.018159660807597244 6.789528513798097e-11 10.168160383446352 -0.09150981639436717 PMFIVNTNVPR ddPTM_RPMI8226_Bortezomib_8h_R1 2 PMFIVNTNVPR 11 0 P14174 P14174 MIF Macrophage migration inhibitory factor 0 2368105400.0 448665800.0 1137344600.0 782095000.0 False True 680658820.463614 934376570.0160799 627513580.4455844 1.0 1.3727531942943931 0.9219208825034677 29.342356589103527 -6.687122512717872 1.8764832390961557 1.234319935199433 0.9235251756054407 0.35702549454657684 0.15774179875838923 0.42290452744183216 2.884810594092824 0.06730328196166867 0.17591095547842503 2.0553107193514548e-07 6.687122512717872 -0.3107947595939923 PMFIVNTNVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 PMFIVNTNVPR 11 0 P14174 P14174 MIF Macrophage migration inhibitory factor 0 1794247700.0 538037700.0 481882800.0 774327200.0 False True 736964777.61213 460591624.5226773 591447063.1292685 1.0 0.6249845834085304 0.8025445463562594 29.457020428109047 -10.104939626324976 4.858504881644532 1.000011550555462 0.7137645648828808 0.7760327117334782 0.07248855133890432 1.007070151735671e-05 1.8553161616785504e-06 0.07018988155812388 0.023395579342306728 7.853448021411898e-11 10.104939626324976 -0.28624698567258133 PMFIVNTNVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 PMFIVNTNVPR 11 0 P14174 P14174 MIF Macrophage migration inhibitory factor 0 1075651600.0 491113300.0 232818100.0 351720200.0 False True 408382468.9581429 231563862.68452516 425263267.6495371 1.0 0.5670269423545193 1.041335757468875 28.60534569463389 -6.666627352119134 1.9506385620197928 0.7228200631812076 1.0393399534247534 0.26373638169131297 0.18406476683620823 0.4688456678539346 3.436364691978393 0.07607850391783083 0.20406364183068276 2.1546297292562776e-07 6.666627352119134 0.31651989024354577 PMFIVNTNVPR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 PMFIVNTNVPR 11 0 P14174 P14174 MIF Macrophage migration inhibitory factor 0 2505977900.0 448665800.0 1285780100.0 771532000.0 False True 580806722.6251189 1214225307.1434555 631121092.5868374 1.0 2.0905841131718033 1.0866284221613494 29.113482911195977 -6.626583865816253 2.0934858742785734 1.72030099694404 1.0906586223929324 0.10512576652761396 0.46821450236380946 0.5679438751267185 4.739057520224888 0.1832378234452093 0.5186080530585313 2.3627410904691545e-07 6.626583865816253 -0.6296423745511075 PMHVK(ub)MDER ddPTM_RPMI8226_Bortezomib_1h_R1 1 PMHVKMDER 9 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 6785000.0 1509600.0 2557700.0 2717700.0 True False 1979100.2189871948 2176101.1298365123 2436498.4740192085 1.0 1.0995406442580926 1.231114246082034 20.916413239706042 -6.967273526175569 0.3166138628140805 0.9812498328037151 1.3536278547790044 0.9999526288017602 0.000651444313498373 0.07719769831376536 0.012182516755030287 0.0020224988907459533 0.011608781246785568 1.0782673968723068e-07 6.967273526175569 0.37237802197528924 PMHVK(ub)MDER ddPTM_RPMI8226_Bortezomib_2h_R1 1 PMHVKMDER 9 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 9455700.0 2683600.0 3172900.0 3599200.0 True False 2598410.5869283746 4439855.516454915 2656461.546314462 1.0 1.7086812756960568 1.0223409493781006 21.309197985068717 -10.175474500394559 4.712467516873964 0.9999524280502455 1.3655111125395147 0.27438809870188274 0.2801972649040721 0.00014006205363708922 2.4507127540220116e-05 0.2713350742808849 0.0904332783843445 6.676140987829426e-11 10.175474500394559 0.3655586844892692 PMHVK(ub)MDER ddPTM_RPMI8226_Bortezomib_8h_R1 1 PMHVKMDER 9 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 25871900.0 5467900.0 7187000.0 13217000.0 True False 8295204.057035324 5904423.697712707 10604654.156783106 1.0 0.7117876374246696 1.2784078708454547 22.98384604037294 -6.768416507217037 1.5803796812372704 0.8343553854846831 1.2814160646404553 0.7245150251203625 0.12141912046651714 0.2689982262362579 1.3256556880234205 0.06056561907917176 0.1443897026964987 1.7044469664491024e-07 6.768416507217037 0.4470606791557722 PMHVK(ub)MDER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PMHVKMDER 9 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 4474800.0 1509600.0 1550000.0 1415200.0 True False 2067739.9154060595 1481515.8748354341 1080958.9069588957 1.0 0.7164904366342885 0.5227731490334068 20.979623301228933 -8.023215940995987 0.11984289668390781 1.439640414574199 6.383311218389845e-11 0.9999789166152107 0.0008998247973314039 0.10415666072412631 0.020282225218447948 0.10560875759810696 0.12175728708944882 9.47947005503577e-09 8.023215940995987 -1.4396404145103658 PMHVK(ub)MDER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PMHVKMDER 9 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 7649900.0 2683600.0 3757800.0 1208500.0 True False 2231532.3036376163 3737555.9855351034 1461191.7625273322 1.0 1.6748832089244332 0.6547930138163119 21.089603260502994 -6.728320605275025 1.7292956576802962 1.406914367782538 0.65558744633541 0.5513856573701492 0.28374685632011853 0.3394491631719689 1.9879022066635448 0.13006767644964842 0.3233767129930797 1.869301673269546e-07 6.728320605275025 -0.751326921447128 PMINLYTDKDTGKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PMINLYTDKDTGKPK 15 2 Q92804-2;Q92804;A0A075B7D9 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 0 11677000.0 2576300.0 3701100.0 5399600.0 False True 3377554.248924689 3148910.306774805 4840901.188620572 1.0 0.9323048794189828 1.43325638371664 21.687547511051623 -6.872798898397104 1.1191272693437173 0.9609791337843838 1.4642057176414025 0.9674003793439712 0.0400689066264168 0.13420238043526636 0.31243450541958356 0.027735611675286473 0.06600646029580556 1.3402971731238935e-07 6.872798898397104 0.5032265838570187 PMINLYTDKDTGKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PMINLYTDKDTGKPK 15 2 Q92804-2;Q92804;A0A075B7D9 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 0 9434800.0 2576300.0 2607000.0 4251500.0 False True 3528827.7318896605 2491814.119803859 3247383.2623909977 1.0 0.706130848294346 0.9202442026412121 21.750757572574514 -9.823200554914205 5.733713626776783 1.0000000334175676 0.8131875262474991 0.5037203161948592 0.0874114108802744 3.736061526123681e-08 7.588520987327286e-09 0.08463575041539564 0.0282119115502587 1.5024479832640434e-10 9.823200554914205 -0.18681250717006848 PMLEGVK(ub)YLCIPAADSPSQNLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PMLEGVKYLCIPAADSPSQNLTR 23 1 Q9NRW4;Q9NRW4-2 Q9NRW4 DUSP22 Dual specificity protein phosphatase 22 1 6913600.0 1147500.0 2584300.0 3181800.0 True False 1571761.760021497 2470117.0808627196 2430324.371227961 1.0 1.5715594714741856 1.546242206067363 20.58395112681702 -10.03603711523682 4.800704179037472 0.9999869884070952 1.5589008387814505 0.9984634113425039 0.01033573036032542 1.457110843223377e-06 2.925641636419011e-07 0.010007763571561603 0.003335842624189002 9.203709125817753e-11 10.03603711523682 0.5589138503743553 PMSAYMLWLNASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PMSAYMLWLNASR 13 0 Q08945;A0A0U1RRK2 Q08945 SSRP1 FACT complex subunit SSRP1 0 6513600.0 3138900.0 1673800.0 1700900.0 False True 2610134.4268475557 1664782.9071767142 2056550.325926966 1.0 0.6378150067877502 0.7879097355191808 21.31569267954929 -10.150278480959296 5.1770059622938955 1.0000114571537888 0.7128623721300098 0.8299216537272243 0.06127591641310883 8.103287839119388e-06 1.3300791493205247e-06 0.05933251658750063 0.019776716982506274 7.074919765781273e-11 10.150278480959296 -0.287149085023779 PMVYLVNLSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PMVYLVNLSEK 11 0 J3KQ32;Q9NTK5;Q9NTK5-2;Q9NTK5-3;C9JCJ9 J3KQ32 OLA1 Obg-like ATPase 1 0 8728800.0 2635200.0 3066400.0 3027200.0 False True 3454772.719313098 2608905.072733583 2713974.3829528447 1.0 0.7551596833415726 0.7855724828961993 21.72015937183195 -9.964510095476536 6.869154391999016 1.0000000177049813 0.7703660832116785 0.9870154754688605 0.012415973426399487 3.3707917136025925e-09 5.085315834274477e-10 0.012021715562103815 0.004007238192282807 1.0851503242674502e-10 9.964510095476536 -0.22963393449330272 PMVYLVNLSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PMVYLVNLSEK 11 0 J3KQ32;Q9NTK5;Q9NTK5-2;Q9NTK5-3;C9JCJ9 J3KQ32 OLA1 Obg-like ATPase 1 0 8530600.0 3312400.0 1487500.0 3730700.0 False True 3207249.6751160882 2081466.5072100265 2753517.7513990263 1.0 0.6489879859866808 0.8585292790775202 21.61290523711402 -10.28134893203845 5.591974218592707 1.0000235875465409 0.7537586325320955 0.6480468376529083 0.08554487468594002 2.5158468484215284e-05 3.2332313063795234e-06 0.08283639529796616 0.027609489584334634 5.2317992101445266e-11 10.28134893203845 -0.24626495501444534 PMVYLVNLSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PMVYLVNLSEK 11 0 J3KQ32;Q9NTK5;Q9NTK5-2;Q9NTK5-3;C9JCJ9 J3KQ32 OLA1 Obg-like ATPase 1 0 12389400.0 2635200.0 4511800.0 5242400.0 False True 3609504.6536023086 4312453.757472597 4004253.0906170956 1.0 1.1947494660157152 1.1093636038454266 21.783369433354842 -10.117196108366217 4.210409471603144 0.9999714742895628 1.1520565349512262 0.8087372194701105 0.03485863233846948 24305933.046547357 0.4752834913367533 6875.285221086721 0.01193303702329103 7.634909466558124e-11 10.117196108366217 0.15208506066166338 PMVYLVNLSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PMVYLVNLSEK 11 0 J3KQ32;Q9NTK5;Q9NTK5-2;Q9NTK5-3;C9JCJ9 J3KQ32 OLA1 Obg-like ATPase 1 0 7483200.0 3312400.0 1710500.0 2460300.0 False True 2754407.3642007858 1701285.196992333 2974737.354858081 1.0 0.6176592537124497 1.0799917955204952 21.393310512548297 -6.6870881902015915 1.8766542786710676 0.7596436552015532 1.0783437438197188 0.35683180997820274 0.16180053064630803 0.42298507169901894 2.8858711527643055 0.0690301501858274 0.18042905739040338 2.055473158033459e-07 6.6870881902015915 0.31870008861816557 PNGLILQYGTAGFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PNGLILQYGTAGFR 14 0 D6RCD1;D6RC77;D6RCQ8;D6RF77;A0A494C163;A0A494C099;A0A494C0G1;H0Y987;O95394;O95394-3;O95394-4 D6RCD1 PGM3 Phosphoacetylglucosamine mutase 0 5799300.0 1468100.0 1826400.0 2504800.0 False True 2010896.2439107301 1745703.608902863 1913217.8279752976 1.0 0.8681221690025496 0.9514254322015787 20.939407214240877 -10.322940663679878 4.995179738147314 1.0000374367743161 0.9097738006031166 0.6100081048307808 0.03400841479115671 1.4184653236862802e-05 1.9226153242298688e-06 0.032942162916425426 0.010976168676408844 4.754001739703573e-11 10.322940663679878 -0.09026363617119948 PNHTIYINNLNEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PNHTIYINNLNEK 13 0 P09012;M0QXK2;M0R221;M0R2B8;M0R268;M0R0G9 P09012 SNRPA U1 small nuclear ribonucleoprotein A 0 11587000.0 2529400.0 3382600.0 5675000.0 False True 3316067.8947444404 2877929.265271532 5087805.438443907 1.0 0.8678740474019533 1.5342886816362995 21.661042114881706 -6.855184074149053 1.2097315993556925 0.9290403135123735 1.563728954368048 0.9475236588061952 0.06599781777793222 0.1518467866548117 0.42501860139920605 0.04262464607551414 0.09902562706388308 1.3957766407728517e-07 6.855184074149053 0.6346886408556744 PNHTIYINNLNEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PNHTIYINNLNEK 13 0 P09012;M0QXK2;M0R221;M0R2B8;M0R268;M0R0G9 P09012 SNRPA U1 small nuclear ribonucleoprotein A 0 8503800.0 2529400.0 2741100.0 3233300.0 False True 3464587.5344648142 2619989.138394457 2469661.131903752 1.0 0.7562196400961118 0.7128297690089244 21.724252176404597 -13.999999999999998 0.2427816650593734 2.635616851450097 0.6941449618128851 0.9995296626803021 0.002741126977808296 13.72332088801792 0.1559375073951068 10.900006599647137 0.020860951410866593 1.0000000000000041e-14 13.999999999999998 -1.9414718896372118 PNIVLFSGSSHQDLSQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PNIVLFSGSSHQDLSQR 17 0 P11908;P11908-2;D3YTJ7;A6NMS2 P11908 PRPS2 Ribose-phosphate pyrophosphokinase 2 0 67201000.0 20205000.0 17373000.0 29623000.0 False True 26488950.665498305 14781016.11942359 26557896.12388089 1.0 0.5580068575036373 1.0026028006640666 24.65888735806378 -10.940832624502674 11.199084971819122 1.047774928428808 0.7803048290838519 0.2456094217330932 0.18150553374241404 0.1048767250524873 0.0005540874681464573 0.08512953331938734 0.0585806591190715 1.1459545030061311e-11 10.940832624502674 -0.26747009934495614 PNIVLFSGSSHQDLSQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PNIVLFSGSSHQDLSQR 17 0 P11908;P11908-2;D3YTJ7;A6NMS2 P11908 PRPS2 Ribose-phosphate pyrophosphokinase 2 0 47102000.0 13190000.0 8111000.0 25801000.0 False True 12771290.669840975 11349764.59830623 19042944.086591344 1.0 0.8886936247648299 1.4910743619327915 23.6064009957429 -6.858988722753112 1.1907696938637806 0.9397599097500124 1.5196945406331863 0.952400807435833 0.057096811430790026 0.14785433576228146 0.39893623403441975 0.037411894933452816 0.08723728823839735 1.383602306258154e-07 6.858988722753112 0.5799346308831739 PNIVLFSGSSHQDLSQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PNIVLFSGSSHQDLSQR 17 0 P11908;P11908-2;D3YTJ7;A6NMS2 P11908 PRPS2 Ribose-phosphate pyrophosphokinase 2 0 42460600.0 9527600.0 19144000.0 13789000.0 False True 14454065.760860614 15727603.627245303 11063598.106066607 1.0 1.0881093172990284 0.7654315601652463 23.784972027386186 -6.833951060667297 1.3102535988032742 1.0469657417022384 0.7560321439152586 0.9135307001599355 0.04004482398709713 0.17598709219115014 0.5894860167910906 0.02398668011421532 0.05520089304882122 1.4657129984185132e-07 6.833951060667297 -0.2909335977869798 PNIVLFSGSSHQDLSQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PNIVLFSGSSHQDLSQR 17 0 P11908;P11908-2;D3YTJ7;A6NMS2 P11908 PRPS2 Ribose-phosphate pyrophosphokinase 2 0 68015000.0 20205000.0 19766000.0 28044000.0 False True 27675334.519594196 18892672.762578852 21420584.7843098 1.0 0.6826538175790721 0.7739955146393617 24.72209741958667 -10.189757647630085 7.579960408346323 1.0000001960853993 0.7283246661092171 0.921844976062764 0.0372900916729313 1.2357898143405662e-07 1.3202185491226215e-08 0.036106001831545935 0.012035325335650899 6.460146285028625e-11 10.189757647630085 -0.27167552997618216 PNIVLFSGSSHQDLSQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PNIVLFSGSSHQDLSQR 17 0 P11908;P11908-2;D3YTJ7;A6NMS2 P11908 PRPS2 Ribose-phosphate pyrophosphokinase 2 0 33328700.0 13190000.0 9337700.0 10801000.0 False True 10968069.416075474 9287395.956711663 13059439.161818529 1.0 0.8467667010841021 1.190678018747567 23.386806271177175 -6.785626950890332 1.514219667825729 0.9138673040686204 1.1938847055189015 0.7866918246097057 0.0649727080239007 0.24193849547334062 1.095985961882122 0.033786214080286654 0.07934558591956518 1.638223113723828e-07 6.785626950890332 0.2800174014502811 PNIVLFSGSSHQDLSQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PNIVLFSGSSHQDLSQR 17 0 P11908;P11908-2;D3YTJ7;A6NMS2 P11908 PRPS2 Ribose-phosphate pyrophosphokinase 2 0 40371600.0 9527600.0 19428000.0 11416000.0 False True 12333666.017073486 18346814.72141546 9338405.138051756 1.0 1.4875394465861145 0.7571475605975229 23.556098349478635 -6.726790126710944 1.7348810361162663 1.2944406737665255 0.7578258262211539 0.5443567147123793 0.20500669040280842 0.3422833183299022 2.016739129960216 0.09370016771810873 0.23336503009407708 1.8759008202092164e-07 6.726790126710944 -0.5366148475453716 PNLPIPSTVLRK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PNLPIPSTVLRK 12 1 Q5VUA4 Q5VUA4 ZNF318 Zinc finger protein 318 0 27955000.0 4058800.0 19541700.0 4354500.0 False True 5321126.105475106 16626154.532949999 3903938.111313482 1.0 3.124555630403633 0.7336676549154837 22.34330016370912 -6.672210450532244 1.9291449931071896 2.3534299252212993 0.7431095599876233 0.2891673421034793 0.9019914861061672 0.45597872368115283 3.2735623215631837 0.3760980576814545 1.002095729188417 2.127108041636339e-07 6.672210450532244 -1.610320365233676 PNLPIPSTVLRK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PNLPIPSTVLRK 12 1 Q5VUA4 Q5VUA4 ZNF318 Zinc finger protein 318 0 74521400.0 43920000.0 20732000.0 9869400.0 False True 42525783.640592515 29010395.715951737 7284308.064346515 1.0 0.6821836832245975 0.17129156574538368 25.341834485496552 -7.323931143716499 0.47800741665307034 1.0150308677922084 6.450293066493128e-29 0.9986879396010891 0.012365079321403209 0.10310673492983637 0.04647135645766596 0.01452082217430034 0.05700135347967604 4.7431718107950974e-08 7.323931143716499 -1.0150308677922084 down PNLPIPSTVLRK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PNLPIPSTVLRK 12 1 Q5VUA4 Q5VUA4 ZNF318 Zinc finger protein 318 0 13668300.0 4058800.0 0.0 9609500.0 False True 5559448.044945752 0.0 7339934.013864819 1.0 0.0 1.3202630826881736 22.40651022523201 -6.704162463796008 1.815923836414462 0.38157372877842616 1.3166634788323879 0.4372981859540035 0.42180297665908023 0.38697970812032656 2.483667577811123 0.18510411680627323 0.47362616533260626 1.9762302203460328e-07 6.704162463796008 0.9350897500539617 PNLPIPSTVLRK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PNLPIPSTVLRK 12 1 Q5VUA4 Q5VUA4 ZNF318 Zinc finger protein 318 0 90966500.0 43920000.0 40119000.0 6927500.0 False True 36521425.98590103 39902870.98400201 8376008.22085898 1.0 1.092587978339246 0.2293450486871052 25.122239760930828 -6.880360319222407 1.0778282783317001 1.0576563112407904 0.1677532136238125 0.973973168892712 0.06242825011404627 0.12730951209827807 0.27038365825198024 0.044604122683190195 0.1079599033452526 1.3171634797782222e-07 6.880360319222407 -0.889903097616978 down PNTLTLVHVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PNTLTLVHVR 10 0 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 0 14270400.0 4171100.0 4272200.0 5827100.0 False True 5468352.492989861 3634804.412905169 5224167.589490128 1.0 0.6646982647085747 0.9553458004375603 22.382674812176283 -10.162682873574825 7.26785607503688 1.0000001560280678 0.8100220336135215 0.3629173318423371 0.11865635958889291 3.000219533487274e-07 3.4508715670731205e-08 0.114888621166091 0.0382961753841151 6.875703278773792e-11 10.162682873574825 -0.18997812241454626 PNTLTLVHVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PNTLTLVHVR 10 0 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 0 13017500.0 4171100.0 4437100.0 4409300.0 False True 5713268.38973915 4241054.250472456 3367914.1523840087 1.0 0.7423166497987834 0.5894899246169979 22.445884873699175 -11.515626600143444 0.07336273079107068 2.090747036520972 9.472678920495911e-23 0.9999553179451894 0.0011323509660957091 4.519584169245364 0.050557472661631 1.2094490436963412 0.4064190778081175 3.050516650720096e-12 11.515626600143444 -2.090747036520972 PNTLTLVHVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PNTLTLVHVR 10 0 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 0 4292700.0 1361100.0 1456500.0 1475100.0 False True 1131814.9569537772 1448653.5454073865 1783536.5899082078 1.0 1.2799385062964395 1.5758199509118578 20.110206677222806 -6.970424700355298 0.247844746657324 0.9035760731179896 1.9608245571450715 0.9999855043003831 0.0008951114660662519 0.07616523678551704 0.008536192982179962 0.006696817774820384 0.028458374316272152 1.0704719693620916e-07 6.970424700355298 1.057248484027082 PNVIVVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PNVIVVQK 8 0 E9PMC9;Q7Z589-2;Q7Z589-6;Q7Z589;Q7Z589-5;Q7Z589-4;Q7Z589-7 E9PMC9 C11orf30;EMSY Protein EMSY 0 95103000.0 34518000.0 30379000.0 30206000.0 False True 45253432.27278754 25846571.61641452 27080572.876411755 1.0 0.5711516302368287 0.5984203079485806 25.431523882598356 -10.715000604235495 6.780288433680301 1.0048516996788157 0.5847859690927194 0.9967756445312073 0.011132391059032756 0.0008212811481597842 3.452129435864867e-05 0.010842602935420225 0.003592963764591851 1.927522231420366e-11 10.715000604235495 -0.4200657305860963 PNVIVVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PNVIVVQK 8 0 E9PMC9;Q7Z589-2;Q7Z589-6;Q7Z589;Q7Z589-5;Q7Z589-4;Q7Z589-7 E9PMC9 C11orf30;EMSY Protein EMSY 0 49886700.0 18136000.0 7898700.0 23852000.0 False True 17560282.607144497 11052692.10117635 17604445.655338008 1.0 0.6294142496704183 1.0025149394905264 24.065812727344777 -10.951883056987608 10.530892433808077 1.0573042760341949 0.8159645945807723 0.24494474685072098 0.15231771878994718 0.09198055783482216 0.0004202700355062263 0.06619538186629585 0.049160332350480805 1.1171640274227576e-11 10.951883056987608 -0.24133968145342255 PNVIVVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PNVIVVQK 8 0 E9PMC9;Q7Z589-2;Q7Z589-6;Q7Z589;Q7Z589-5;Q7Z589-4;Q7Z589-7 E9PMC9 C11orf30;EMSY Protein EMSY 0 86790000.0 12869000.0 57259000.0 16662000.0 False True 19523213.849921837 47040684.08339106 13368748.39678597 1.0 2.409474405443722 0.6847616637073047 24.218687228571955 -6.689424179556305 1.868189240885746 1.8840993974308315 0.6907076386826712 0.36790326421755604 0.5961735419131401 0.41787732318623017 2.827152852918003 0.2553180259735034 0.6654157059727414 2.044446830556462e-07 6.689424179556305 -1.1933917587481604 PNVIVVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PNVIVVQK 8 0 E9PMC9;Q7Z589-2;Q7Z589-6;Q7Z589;Q7Z589-5;Q7Z589-4;Q7Z589-7 E9PMC9 C11orf30;EMSY Protein EMSY 0 92340000.0 34518000.0 25830000.0 31992000.0 False True 47280237.4138755 24688745.191612463 24436148.495922092 1.0 0.5221789597944567 0.5168364169159338 25.494733944121247 PNVIVVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PNVIVVQK 8 0 E9PMC9;Q7Z589-2;Q7Z589-6;Q7Z589;Q7Z589-5;Q7Z589-4;Q7Z589-7 E9PMC9 C11orf30;EMSY Protein EMSY 0 36212200.0 18136000.0 12134000.0 5942200.0 False True 15080887.5610269 12068631.733589571 7184686.546371456 1.0 0.8002600433662928 0.47641005990513674 23.846218002779054 -6.963932052164709 0.37593018169075054 1.0232887805632722 0.24200273848352077 0.9998894101172252 0.002268826326593915 0.07832524635900118 0.016149309041768808 0.004233976055069348 0.027419741452176793 1.0865956143664465e-07 6.963932052164709 -0.7812860420797514 down PPFTNLHVSYQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PPFTNLHVSYQK 12 0 Q9H488;Q9H488-2 Q9H488 POFUT1 GDP-fucose protein O-fucosyltransferase 1 0 14116600.0 3431200.0 2962400.0 7723000.0 False True 4498336.427788068 2520421.4673447553 6923898.044247108 1.0 0.5603007929275985 1.5392130302827844 22.100960132741154 -6.784579064379507 1.5178008129122187 0.7525118813526986 1.548142620237929 0.7833297989406112 0.18634359019728874 0.24352438133110701 1.1082846493072775 0.09666660081193146 0.22725751924697554 1.6421806694261841e-07 6.784579064379507 0.7956307388852303 PPFTNLHVSYQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PPFTNLHVSYQK 12 0 Q9H488;Q9H488-2 Q9H488 POFUT1 GDP-fucose protein O-fucosyltransferase 1 0 15554300.0 4229100.0 2028900.0 9296300.0 False True 4094849.5353922998 2839050.3505737283 6861320.146977977 1.0 0.6933222639893014 1.675597622739181 21.965379010560056 -6.822834249205589 1.3597645646677652 0.8351639566613952 1.698338045259518 0.8907358684181993 0.13563562774608826 0.18982609530177152 0.6889018846944358 0.07837344396189308 0.18049838895899634 1.5037157576889435e-07 6.822834249205589 0.8631740885981228 PPFTNLHVSYQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PPFTNLHVSYQK 12 0 Q9H488;Q9H488-2 Q9H488 POFUT1 GDP-fucose protein O-fucosyltransferase 1 0 14777700.0 3431200.0 2790200.0 8556300.0 False True 4699807.364693479 2666919.738042475 6535478.162529951 1.0 0.5674529892602123 1.3905842634374004 22.164170194264045 -6.763896036843361 1.597676661285585 0.7499831236949 1.3942020954356735 0.7067736944544526 0.1820467687683043 0.2763903801876966 1.3912705397578324 0.08986582560675609 0.21515031251173167 1.7222808121377918e-07 6.763896036843361 0.6442189717407736 PPSAFFLFCSEHRPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PPSAFFLFCSEHRPK 15 1 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 136500000.0 29066000.0 37594000.0 69840000.0 False True 38105807.475544356 31985121.74026427 62613626.75258547 1.0 0.8393765638162047 1.6431518159737148 25.183507551108182 -6.854737653277565 1.2118813686831296 0.9137925724461803 1.678366494657983 0.946929834347456 0.08000527828888888 0.15232812472764462 0.42811484198987415 0.05158565140357404 0.11980160317840469 1.3972121280083377e-07 6.854737653277565 0.7645739222118028 PPSAFFLFCSEHRPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PPSAFFLFCSEHRPK 15 1 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 99652300.0 51116000.0 15883300.0 32653000.0 False True 49493350.55948374 22225584.520315304 24100199.730997484 1.0 0.4490620309409729 0.4869381332757536 25.560731376085663 -9.925916930451715 5.845705857830734 1.0000002799872867 0.4680000838758722 0.9962127771265161 0.015462854028806696 5.642680370220992e-08 1.0380727829603738e-08 0.014971851842283678 0.004990614678025431 1.1859955774256185e-10 9.925916930451715 -0.5320001961114145 PPSAFFLFCSEHRPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PPSAFFLFCSEHRPK 15 1 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 137063000.0 47312000.0 55554000.0 34197000.0 False True 71775762.97051068 45639954.65461684 27437947.96092245 1.0 0.6358686103186137 0.38227316332667094 26.09699342545621 -8.067149637613424 0.18018688009113096 1.295772866899033 5.298851112947544e-12 0.9998840658120132 0.002729801075349351 0.09592696833801109 0.03291968327778534 0.09209366158809414 0.11100289884699416 8.567426008466248e-09 8.067149637613424 -1.295772866893734 down PPSAFFLFCSEHRPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PPSAFFLFCSEHRPK 15 1 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 111861000.0 29066000.0 20798000.0 61997000.0 False True 39812485.67911531 19879075.590211228 47354585.46829459 1.0 0.49931761986515 1.1894405652027824 25.246717612631073 -6.712107921152796 1.787606265661856 0.6928597625580514 1.1879287237634928 0.4751575467539575 0.2109162418759121 0.37084886952477253 2.3113333723053158 0.09384663311860898 0.23781467427185238 1.940403631958185e-07 6.712107921152796 0.4950689612054414 PPSAFFLFCSEHRPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PPSAFFLFCSEHRPK 15 1 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 91693600.0 51116000.0 9500600.0 31077000.0 False True 42505218.822753094 9449418.382078553 37575057.01618693 1.0 0.22231195706773466 0.8840104358214234 25.34113665151994 -10.659559526210902 9.239643537751153 1.0003195966781475 0.5531611964456393 0.37811846514794756 0.27013727275373217 0.0017796492081734044 6.557224142722205e-05 0.26173425779912346 0.08718642988042459 2.1899816394896978e-11 10.659559526210902 -0.4471584002325082 PPSAFFLFCSEHRPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PPSAFFLFCSEHRPK 15 1 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 192314000.0 47312000.0 128548000.0 16454000.0 False True 61246316.65894673 121394190.79722635 13459540.832297074 1.0 1.9820651660281248 0.21976082100164848 25.868119747548658 -6.755425506375476 1.6295173065053914 1.5736394071048794 0.21467760064153008 0.6721768529789801 0.4128310679501669 0.2906213779430156 1.5197796625501172 0.19999342531473835 0.48284455138303145 1.7562021060409376e-07 6.755425506375476 -1.3589618064633493 PPSAFFLFCSEYRPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PPSAFFLFCSEYRPK 15 1 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 44211000.0 11342000.0 18528000.0 14341000.0 False True 14869471.836084232 15763694.62157833 12857130.888585735 1.0 1.0601381673371921 0.8646662793620494 23.825850067957305 -6.824093402124684 1.3539293802551366 1.032287713698819 0.8600074696228728 0.893566214923346 0.026668837176396155 0.188216843132104 0.6767859757145982 0.015473486029394167 0.035633528060763156 1.4993623384540937e-07 6.824093402124684 -0.17228024407594633 PPSAFFLFCSEYRPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PPSAFFLFCSEYRPK 15 1 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 66304000.0 35005000.0 15227000.0 16072000.0 False True 33893785.435768284 21307220.507756017 11862261.05033509 1.0 0.6286468222363383 0.3499833641425247 25.014517437782626 -7.8386307601126886 0.20992961591335665 1.2164779777654218 3.9487139122681813e-16 0.999854659371521 0.0032100255593625424 0.1214998260765474 0.03140666598273773 0.05929496216968053 0.09176512254335728 1.4500041322156277e-08 7.8386307601126886 -1.2164779777654213 down PPSAFFLFCSEYRPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PPSAFFLFCSEYRPK 15 1 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 235076000.0 86688000.0 77505000.0 70883000.0 False True 131512033.7417068 63673627.20067114 56872943.98087749 1.0 0.48416578611907 0.43245429610325614 26.9706195755379 -13.999999999999998 0.3251194625219586 6.453021680569252 0.4227645114014473 0.9997046231373867 0.0044036371614528825 18.419348343473644 0.18208176306970314 68.50591295396414 0.016879265083524005 1.0000000000000041e-14 13.999999999999998 -6.030257169167805 PPSAFFLFCSEYRPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PPSAFFLFCSEYRPK 15 1 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 60224000.0 11342000.0 17165000.0 31717000.0 False True 15535443.90602512 16406593.54293563 24226097.832119316 1.0 1.0560749755320897 1.55940814943329 23.889060129480196 -6.928018365924649 0.7628724579933986 0.9917573987331325 1.6577152613127555 0.9961345476220534 0.0156385898153841 0.09367930422488259 0.08281393369730712 0.014083201640644957 0.04604894805721784 1.1802707220046527e-07 6.928018365924649 0.665957862579623 PPSAFFLFCSEYRPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PPSAFFLFCSEYRPK 15 1 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 72140900.0 35005000.0 8490900.0 28645000.0 False True 29108208.48443687 8445157.836388309 34634537.06048439 1.0 0.29012977012665125 1.1898546445756788 24.794922713216902 -6.696350123628419 1.8436608482323154 0.5576352679427079 1.1870223988499635 0.4003640565892843 0.29984958183404675 0.4031696749234178 2.6615834084648813 0.12987041095689397 0.33553339238518964 2.0121014608475506e-07 6.696350123628419 0.6293871309072556 PPSAFFLFCSEYRPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PPSAFFLFCSEYRPK 15 1 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 256659000.0 86688000.0 123020000.0 46951000.0 False True 112219324.87594642 116173828.85672882 38406399.75794215 1.0 1.03523906408414 0.34224408140397167 26.74174589763035 -6.894924272684021 0.9928163120623332 1.03296016343439 0.2765611810543051 0.9838668432401065 0.04048010324726379 0.1152378980394438 0.19924555585921744 0.030848755758883777 0.07840123392961004 1.2737251593130433e-07 6.894924272684021 -0.7563989823800847 down PQAPATVGLAFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PQAPATVGLAFR 12 0 B8ZZU8;Q15370;Q15370-2;I3L0M9 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 0 71927000.0 26181000.0 19973000.0 25773000.0 False True 34323544.537164666 16993106.254144233 23106257.192073114 1.0 0.4950859966034256 0.673189715795647 25.03269520953558 -10.223251366091173 4.8605215146085605 1.0000697502750249 0.5841378561987673 0.8790705205282259 0.0727105388881336 5.496677993030854e-05 8.78404652502679e-06 0.07041344053441535 0.023467225516914457 5.980653395420417e-11 10.223251366091173 -0.4159318940762575 PQAPATVGLAFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PQAPATVGLAFR 12 0 B8ZZU8;Q15370;Q15370-2;I3L0M9 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 0 47461600.0 13735000.0 5870600.0 27856000.0 False True 13298989.943158897 8214761.194774568 20559677.93791279 1.0 0.6176981281950893 1.5459578528735445 23.66481334156721 -6.794865257753933 1.4766740087929728 0.7876669993648323 1.5572171591765127 0.8167178719078604 0.16307682148135874 0.22819385031694295 0.9827947120964378 0.08689904835047398 0.20276962736028495 1.6037428835407702e-07 6.794865257753933 0.7695501598116804 PQAPATVGLAFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PQAPATVGLAFR 12 0 B8ZZU8;Q15370;Q15370-2;I3L0M9 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 0 33727400.0 9107500.0 20061000.0 4558900.0 False True 13816743.347436726 16480957.81269158 3657831.416763146 1.0 1.1928250672579164 0.26473904340430154 23.71991427196603 -6.852495366935003 1.222904379402272 1.1031670761092651 0.22579594240216735 0.9438659571842661 0.09474198927600065 0.15473666953669518 0.4440402333662527 0.06057920173406702 0.1404332534290911 1.4044446661508029e-07 6.852495366935003 -0.8773711337070977 down PQAPATVGLAFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PQAPATVGLAFR 12 0 B8ZZU8;Q15370;Q15370-2;I3L0M9 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 0 65411000.0 26181000.0 17472000.0 21758000.0 False True 35860823.214921884 16700029.267822407 16619208.520076033 1.0 0.4656900698496356 0.463436336095059 25.09590527105847 PQAPATVGLAFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PQAPATVGLAFR 12 0 B8ZZU8;Q15370;Q15370-2;I3L0M9 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 0 32440700.0 13735000.0 9484700.0 9221000.0 False True 11421261.063669195 9433604.038534453 11149068.466913145 1.0 0.8259686899673943 0.9761679034181358 23.445218617001487 -10.182220410709883 6.017138893386112 1.000001187523227 0.9010682967043636 0.3664716816749666 0.06131857212028507 9.76851640137043e-07 1.3269830743895446e-07 0.05937216477931277 0.019790484052923104 6.573241512053101e-11 10.182220410709883 -0.09893289081886347 PQAPATVGLAFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PQAPATVGLAFR 12 0 B8ZZU8;Q15370;Q15370-2;I3L0M9 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 0 25941600.0 9107500.0 11420000.0 5414100.0 False True 11789838.285664476 10784466.961013202 4428789.3533572145 1.0 0.914725605195643 0.37564462260201453 23.49104059405848 -6.934739854180837 0.7068043330018637 1.006936062162971 0.2503139404262854 0.9973905315301517 0.014120632243485993 0.09025034693147034 0.06616389435067896 0.013248828272723187 0.04757067241186728 1.1621445391298587e-07 6.934739854180837 -0.7566221217366856 down PQATAVYK(ub)VSEYAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PQATAVYKVSEYAR 14 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 14440400.0 2184900.0 5025400.0 7230100.0 True False 2115541.545453795 7032068.427114794 5336319.911649318 1.0 3.324003937538545 2.5224368309461154 21.012595587247993 -10.159361321406923 5.672339472703988 0.9999672175740066 2.9232203842424553 0.8847353089425696 0.3272384009588673 0.00013566809201400468 2.010451512904747e-05 0.3168525612919482 0.1056157397627054 6.928491341916235e-11 10.159361321406923 1.9232531666684487 PQATAVYK(ub)VSEYAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PQATAVYKVSEYAR 14 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 6014700.0 1829100.0 1998600.0 2187000.0 True False 2505367.699568906 1910295.243513614 1670475.6426788447 1.0 0.762480989853232 0.6667586729749412 21.256590925006112 -13.999999999999998 0.12521434698378953 2.1291036935683594 0.524187128949884 0.999667786671304 0.002553381581497029 11.94675093402543 0.10953936702886083 3.3356528613140983 0.12661177814928848 1.0000000000000041e-14 13.999999999999998 -1.6049165646184753 PQATAVYK(ub)VSEYAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PQATAVYKVSEYAR 14 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 8881300.0 2184900.0 2741200.0 3955200.0 True False 1816841.1574816764 2726432.6115143984 4782214.033221428 1.0 1.500644456609243 2.6321585756291737 20.79300086268227 -6.957585691060317 0.4682273875749995 0.9695929533536767 3.2094578348557428 0.9996698857794019 0.012404297520680199 0.080575217087977 0.024406092800026043 0.015593415399495185 0.09340236720817115 1.1025906591659826e-07 6.957585691060317 2.239864881502066 PQGGQDILSMMGQLMKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PQGGQDILSMMGQLMKPK 18 1 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3 Q9Y265 RUVBL1 RuvB-like 1 0 3018620.0 619820.0 1080000.0 1318800.0 False True 812590.0223454176 918868.2098070269 1182343.2268228761 1.0 1.130789431987921 1.4550304511618566 19.632168124507707 -6.955641195850513 0.49304033295473726 0.9930958749436182 1.6065444125715747 0.9995728353516574 0.003953354409914647 0.08129650504262378 0.027176388119402373 0.004699285481348452 0.026742848472016967 1.1075384289680568e-07 6.955641195850513 0.6134485376279565 PQGGQDILSMMGQLMKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PQGGQDILSMMGQLMKPK 18 1 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3 Q9Y265 RUVBL1 RuvB-like 1 0 5278740.0 2139500.0 846540.0 2292700.0 False True 2071582.7436030926 1184567.8366477801 1692173.090474319 1.0 0.5718177757106954 0.8168503506314846 20.982302015227482 -10.185346216925764 5.481677485807563 1.000010461109369 0.694334063171053 0.6747801106799621 0.1000341298195015 1.278961559517646e-05 1.9005840076502644e-06 0.09686094330959615 0.03228587657025436 6.526100884169907e-11 10.185346216925764 -0.305676397938316 PQGGQDILSMMGQLMKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PQGGQDILSMMGQLMKPK 18 1 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3 Q9Y265 RUVBL1 RuvB-like 1 0 6909520.0 619820.0 2483100.0 3806600.0 False True 848984.2040056858 2373388.4314863663 2907559.479387881 1.0 2.7955625325986295 3.4247509737747825 19.6953781860306 -9.589087570576027 0.29905934364756276 2.3697052627374732e-15 3.6691172268199876 0.9987521533608708 0.03629159594737939 0.9659512973348992 0.12300177441354318 1.153965998179932 0.2220789615942516 2.5758017233168384e-10 9.589087570576027 3.6691172268199854 PQGGQDILSMMGQLMKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PQGGQDILSMMGQLMKPK 18 1 Q9Y265;Q9Y265-2;E7ETR0;H7C4G5;H7C4I3 Q9Y265 RUVBL1 RuvB-like 1 0 4074970.0 2139500.0 872170.0 1063300.0 False True 1779089.0459206596 867471.4470978099 1285631.1138562784 1.0 0.4875930460517802 0.7226344947736879 20.76270729066176 -10.364157390741365 5.914068284183678 1.0000685575643857 0.6051137704127347 0.7900710454693216 0.0959552696288702 8.675361059959763e-05 9.327149961337299e-06 0.09292433897680263 0.030969430104454475 4.32357114010722e-11 10.364157390741365 -0.394954787151651 PQGSEGTAPSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PQGSEGTAPSR 11 0 Q8IZ96-8;E9PAX0;E9PIL3;Q8IZ96-17 Q8IZ96-8 CMTM1 0 24430300.0 5276400.0 10828000.0 8325900.0 False True 4387560.384153194 10769667.414810292 10066807.195387919 1.0 2.4545912698336245 2.294397413138014 22.06498755008471 -10.209886558574778 4.625441639993618 0.9996955476421842 2.3744943414956756 0.9899152512108732 0.06539886817248296 0.00020536946645182295 3.508073145039119e-05 0.06333552218684137 0.021107393936314285 6.167560827753255e-11 10.209886558574778 1.3747987938534916 PQIAGTK(ub)STTV ddPTM_RPMI8226_Bortezomib_2h_R1 1 PQIAGTKSTTV 11 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 6531600.0 2725100.0 2425000.0 1381500.0 True False 2638593.1921443264 3393315.146207938 1019643.7058883739 1.0 1.2860319492639432 0.3864346004242253 21.331337508121518 -6.821190160000798 1.3667674524181463 1.1539847925471713 0.3662973602125211 0.8870908053364104 0.1261032618951535 0.19193762247405768 0.7042121636327007 0.0724983437765025 0.16704213121912148 1.5094190958332906e-07 6.821190160000798 -0.7876874323346503 down PQIAGTK(ub)STTV ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PQIAGTKSTTV 11 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 5113200.0 2478200.0 1607000.0 1028000.0 True False 3394457.5108368406 1535997.4263616404 785207.572324578 1.0 0.4525015916263358 0.23132048930286936 21.694749596235457 -11.349771240139713 0.16804067856279314 2.14419489223811 1.2177482971500194e-13 0.9995346065915528 0.006970231791710984 3.8526896064000464 0.1015783346737497 1.8129430884476279 0.1763015486449987 4.46918939817301e-12 11.349771240139713 -2.1441948922379885 PQIAGTK(ub)STTV ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PQIAGTKSTTV 11 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 9287600.0 2725100.0 5076500.0 1486000.0 True False 2266041.39239934 5049151.88689364 1796715.7295123008 1.0 2.228181666861555 0.7928874271841497 21.111742783555794 -6.680185198045197 1.901490847580077 1.7769844347336856 0.7983857289060781 0.32479317269970864 0.5205167107938731 0.43815026497040477 3.0631403080324544 0.21965270423373565 0.579126351188494 2.088405373346738e-07 6.680185198045197 -0.9785987058276076 PQIAGTK(ub)STTV ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PQIAGTKSTTV 11 1 Q96GG9;C9JVE2 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 10553100.0 3291300.0 4561200.0 2700600.0 True False 4260652.731222342 4307365.210382956 2209118.510496019 1.0 1.0109636908021868 0.5184929751038976 22.022643037324652 -6.901808672309287 0.9497554033172293 1.0194714461264949 0.4648569786883207 0.9874450638905055 0.02572779408048554 0.11008641682945108 0.1700032882033628 0.02024544416493798 0.05317009511713624 1.2536933657657307e-07 6.901808672309287 -0.5546144674381741 PQYQTWEEFSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PQYQTWEEFSR 11 0 P49458;Q6P2S0;Q659G3;E9PE20;P49458-2 P49458 SRP9;DKFZp564M2223 Signal recognition particle 9 kDa protein 0 31035200.0 5052200.0 13461000.0 12522000.0 False True 6623483.125574399 11452671.270567048 11226343.559505664 1.0 1.7291009961731962 1.694930499054015 22.659158663467952 -10.099465309470524 5.295810117081721 0.9999878821128391 1.712015747614238 0.9982756111936848 0.013950047035419461 1.9959061135984735e-06 3.3940267595282646e-07 0.013507304714340194 0.004502358320263108 7.953067904293697e-11 10.099465309470524 0.7120278655013988 PQYQTWEEFSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PQYQTWEEFSR 11 0 P49458;Q6P2S0;Q659G3;E9PE20;P49458-2 P49458 SRP9;DKFZp564M2223 Signal recognition particle 9 kDa protein 0 22809000.0 9146900.0 1939100.0 11723000.0 False True 8856536.666259926 2713392.742272916 8652394.617538469 1.0 0.30637176184342146 0.9769501266223893 23.078311214918507 -10.77530281035245 9.934768305237615 1.0020988414234326 0.6416609442329054 0.27575042961308927 0.2737624710430664 0.012771738669735883 0.0002888611869467028 0.2660089059418394 0.08835645759719885 1.6776338857057208e-11 10.77530281035245 -0.3604378971905272 PQYQTWEEFSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PQYQTWEEFSR 11 0 P49458;Q6P2S0;Q659G3;E9PE20;P49458-2 P49458 SRP9;DKFZp564M2223 Signal recognition particle 9 kDa protein 0 29120200.0 5052200.0 13052000.0 11016000.0 False True 6920134.870571344 12475319.482807798 8414247.6816416 1.0 1.8027566971072349 1.2159080478942887 22.722368724990844 -9.988976915477648 5.131229746988089 0.9999966947189706 1.5093323725044783 0.5010874391094582 0.2395799578151554 164935173.63232392 11.724840906913466 6440.975729213749 0.08201459201146359 1.0257064452818592e-10 9.988976915477648 0.5093356777855077 PRPK(ub)GLEGERPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PRPKGLEGERPAR 13 3 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 32433800.0 7353600.0 16696000.0 8384200.0 True False 9640640.812363701 14205021.88049826 7516683.410925355 1.0 1.4734520408934788 0.7796871138779008 23.20069761475171 -6.722983851569311 1.7485019498079082 1.287124657310401 0.7805798795442088 0.5265430155291984 0.19916175401124353 0.34957898456191816 2.0902311334861348 0.09038442584243188 0.2261128715111987 1.892413983222868e-07 6.722983851569311 -0.5065447777661921 PRPK(ub)GLEGERPAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PRPKGLEGERPAR 13 3 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 56254020.0 17681000.0 23009020.0 15564000.0 True False 17119726.33309008 32196641.676454213 11487321.490008427 1.0 1.8806750207345617 0.6709991308567247 24.02915630397341 -6.711486626468304 1.7900410604224284 1.5405901309466543 0.6737245725369672 0.4721524507664323 0.37102488236545744 0.3720660331905721 2.324911027045864 0.16489388446519662 0.4181333053619779 1.9431815286459094e-07 6.711486626468304 -0.8668655584096872 PRPK(ub)GLEGERPAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PRPKGLEGERPAR 13 3 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 21537600.0 11224000.0 4987000.0 5326600.0 True False 17027628.58431289 4097030.886391154 4273795.175268287 1.0 0.24061077360858352 0.2509918015950631 24.021374190955783 -10.504943577940026 6.184993202502987 1.0006539810757484 0.24580128760182401 0.9998579276663111 0.00423803692873792 3.824806368200622e-05 3.0614268717023e-06 0.004106661461646898 0.0013678205371344852 3.1264855230912006e-11 10.504943577940026 -0.7548526934739244 PRPK(ub)GLEGERPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PRPKGLEGERPAR 13 3 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 29782000.0 7353600.0 15418000.0 7010400.0 True False 10072424.643567838 14736781.779492099 5354687.903720068 1.0 1.4630818597290651 0.5316185618861418 23.263907676274602 -6.771550707566902 1.5686704126092117 1.2650919588051592 0.5260914974521436 0.7363734378618263 0.19524820414831737 0.26394561794881977 1.2820437525907924 0.09809815737854119 0.23316914315296255 1.6921906552798086e-07 6.771550707566902 -0.7390004613530157 PRPK(ub)GLEGERPAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PRPKGLEGERPAR 13 3 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 57133990.0 17681000.0 34806190.0 4646800.0 True False 14702534.901109202 34618682.1459822 5618424.395624327 1.0 2.3546063572595544 0.38213984414350594 23.809561579407685 -6.721864827209572 1.752469936422849 1.822464168090124 0.38485233945778013 0.5213910958031815 0.5698951453161051 0.35169238248610696 2.111825587374286 0.25810315557773306 0.6465517238972864 1.897296356839555e-07 6.721864827209572 -1.4376118286323438 PRPK(ub)GLEGERPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PRPKGLEGERPAR 13 3 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;A0A2R8Y6L3;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 19446200.0 11224000.0 5447100.0 2775100.0 True False 14529689.258116709 5143964.096614271 2270060.2749305717 1.0 0.3540312531970154 0.15623598238086542 23.792500513048232 -12.889342716726508 0.1830200426749504 3.2163279801443956 1.3154172643525072e-22 0.9994626546695141 0.008351977543168767 7.916016526520691 0.12809914532045383 6.473658789560672 0.14225449151958822 1.290200729970539e-13 12.889342716726508 -3.2163279801443956 PRYELALILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PRYELALILK 10 1 P82932 P82932 MRPS6 28S ribosomal protein S6, mitochondrial 0 12988900.0 4045600.0 8943300.0 0.0 False True 6137470.972977206 7347298.240678172 0.0 1.0 1.1971214646924992 0.0 22.549212865575804 -6.9168627600703 1.2651444685732538 1.1035828474573164 8.85562897019625e-22 0.9574584995317401 0.10809499200944059 0.12408475606550906 0.3976568724764937 0.07019733159215726 0.13750792622499222 1.2109807510219955e-07 6.9168627600703 -1.1035828474573164 down PRYELALILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PRYELALILK 10 1 P82932 P82932 MRPS6 28S ribosomal protein S6, mitochondrial 0 16573800.0 4045600.0 7742700.0 4785500.0 False True 5237108.950698227 7311811.938619695 3914588.1033765445 1.0 1.3961542537022955 0.7474711983707424 22.320339187668253 -6.741430256072396 1.6815311971979754 1.2353176679597404 0.7469756210125269 0.6113361696724965 0.1664422955162712 0.3152245306946376 1.7506488405176523 0.07828912746514154 0.19180838529663913 1.8137179198539634e-07 6.741430256072396 -0.4883420469472135 PSAAGINLMIGSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PSAAGINLMIGSTR 14 0 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 0 51516000.0 12878000.0 18797000.0 19841000.0 False True 16883182.710729387 15992560.870132135 17788043.648311116 1.0 0.9472479889688539 1.053595400410296 24.009083561631122 -6.7717833419583915 1.5672811133367333 0.9698135119129777 1.0542397362057365 0.7375171945235756 0.022243661084307653 0.2635232214194118 1.2776755985355994 0.011184545686865378 0.02658430302017948 1.6912844583464433e-07 6.7717833419583915 0.08442622429275881 PSAAGINLMIGSTR ddPTM_RPMI8226_Bortezomib_2h_R1 2 PSAAGINLMIGSTR 14 0 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 0 73636300.0 23638800.0 16221800.0 33775700.0 False True 22888399.23322492 22699249.335569438 24928830.920719463 1.0 0.9917359927302861 1.089146980822173 24.448113231559304 -6.886277560730635 1.0441275960089582 0.994289472543263 1.0969395308755459 0.9784076863709261 0.006480395557542425 0.12221644137679942 0.23989429893776495 0.004750534563940702 0.011695331214857507 1.2993388957695421e-07 6.886277560730635 0.1026500583322828 PSAAGINLMIGSTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PSAAGINLMIGSTR 14 0 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 0 83256000.0 18577000.0 35976000.0 28703000.0 False True 28182667.160618342 29555801.718229074 23029839.469028167 1.0 1.0487226616907825 0.8171632350400607 24.74830481657279 -6.851752227082242 1.2266060681742967 1.026044286286851 0.8075887647021234 0.9428167232527205 0.02383623974390745 0.15553986414883816 0.4494515173925574 0.015198932643956711 0.035212867440089675 1.4068499287417486e-07 6.851752227082242 -0.2184555215847277 PSAAGINLMIGSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PSAAGINLMIGSTR 14 0 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 0 90511000.0 12878000.0 20373000.0 57260000.0 False True 17639344.61486435 19472853.495498296 43736367.30671727 1.0 1.1039442746126114 2.4794780226619895 24.072293623154014 -6.92203125265791 0.8095223527535271 0.9718144287370869 2.7119984451970534 0.9947267696120674 0.04896342683241933 0.0969911932212017 0.09952983021046603 0.042647304783466816 0.1303379873642273 1.1966544146783482e-07 6.92203125265791 1.7401840164599665 up PSAAGINLMIGSTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PSAAGINLMIGSTR 14 0 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 0 45116200.0 19679000.0 8958200.0 16479000.0 False True 16363960.427516988 8909940.398536522 19924682.709712796 1.0 0.5444855747483915 1.2175953857849864 23.964018617727472 -6.724414553314866 1.7432275199116576 0.7241892180851803 1.2168311948646326 0.5333555998626849 0.1915857661755647 0.34680939366790126 2.0618801444470365 0.08718261295521929 0.21774959612468636 1.8861900376001107e-07 6.724414553314866 0.4926419767794523 PSAAGINLMIGSTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PSAAGINLMIGSTR 14 0 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 0 69305000.0 18577000.0 29800000.0 20928000.0 False True 24048292.707415704 28141603.80369471 17119318.7394137 1.0 1.1702121288226321 0.7118725203363258 24.51943113866524 -6.806142492277466 1.4305600558102483 1.093198544497894 0.7045339094673275 0.8495300170553897 0.07337959617963632 0.21212009323978198 0.8562505187369026 0.04034000765716901 0.0934937545115289 1.5626348570981762e-07 6.806142492277466 -0.3886646350305665 PSDSSPPFK(ub)ELLLAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PSDSSPPFKELLLAEK 16 1 P47712 P47712 PLA2G4A Cytosolic phospholipase A2;Phospholipase A2;Lysophospholipase 1 6596100.0 1717200.0 1774700.0 3104200.0 True False 1427927.8848585896 1765139.3388496288 3753273.867800862 1.0 1.2361544007696397 2.6284757848065667 20.44549168959873 -6.93620758994758 0.6939556867009223 0.9828839477143845 2.9654418178781823 0.997623666110327 0.03502549461689081 0.08954025215799678 0.06281422797963955 0.03318435336438244 0.12197024881862718 1.1582236004455691e-07 6.93620758994758 1.9825578701637978 up PSDTIENVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PSDTIENVK 9 0 M0R2S1 M0R2S1 UBA52 0 11512100.0 2045100.0 3434800.0 6032200.0 False True 2681145.9047765746 2922341.228745537 5408045.808948258 1.0 1.0899597905280958 2.017065091203577 21.354418300532014 -6.925708437507485 0.7812095126122426 0.9834361184077698 2.1881429586739465 0.9956255980782363 0.030405189877082354 0.09492806668087721 0.08904958298700856 0.027023506807836394 0.08595119718008017 1.1865650782684589e-07 6.925708437507485 1.2047068402661767 up PSDTIENVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PSDTIENVK 9 0 M0R2S1 M0R2S1 UBA52 0 22801900.0 5932000.0 6114900.0 10755000.0 False True 5743691.907012634 8556611.458782246 7937942.856916002 1.0 1.489740675041299 1.3820279683219683 22.453546934058622 -10.007958444776317 4.760805152847509 0.999991750011174 1.4358843216959107 0.956207011961703 0.043973528428470944 30330431.799772847 3.797281404858618 2743.020535795824 0.015053308400968867 9.818418855150924e-11 10.007958444776317 0.4358925716847367 PSDTIENVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PSDTIENVK 9 0 M0R2S1 M0R2S1 UBA52 0 15309900.0 2045100.0 3622200.0 9642600.0 False True 2801228.736749429 3462159.226986397 7365216.475580725 1.0 1.2359430636870867 2.629280636370805 21.417628362054906 -6.936172991219917 0.6942614569822727 0.9828539276575566 2.966169969615769 0.9976183285548681 0.03508500187158075 0.08955684145819993 0.06289207251681683 0.03323297155700649 0.12207994570129295 1.1583158757584684e-07 6.936172991219917 1.9833160419582123 up PSDTIENVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PSDTIENVK 9 0 M0R2S1 M0R2S1 UBA52 0 25994100.0 5932000.0 6770100.0 13292000.0 False True 4932720.832157672 6733628.1275403565 16071295.744735844 1.0 1.3650941045846559 3.2580995948448868 22.233952209492898 -6.938997996124918 0.6688189455455107 0.9783392767982548 3.7538815700450026 0.9980297098244119 0.04393130881651902 0.08822671709908161 0.05671343092119464 0.042445939822264946 0.16365958857146617 1.1508056988565803e-07 6.938997996124918 2.7755422932467475 up PSDTIENVK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PSDTIENVKAK 11 1 M0R2S1 M0R2S1 UBA52 1 10202300.0 2618200.0 4206700.0 3377400.0 True False 3432485.5546848634 3579076.757588171 3027939.046308451 1.0 1.0427070123290776 0.8821418176620546 21.710822218253472 -6.835956358937011 1.3010484126134543 1.0227439212267402 0.8772698633519568 0.9172744277645082 0.019529888155255866 0.17357511138980117 0.5724778489034958 0.011777788973343514 0.027111288517534842 1.4589608598903624e-07 6.835956358937011 -0.1454740578747834 PSDTIENVK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PSDTIENVKAK 11 1 M0R2S1 M0R2S1 UBA52 1 21672700.0 5054900.0 5482800.0 11135000.0 True False 4894434.9664123645 7672110.632424275 8218409.457160364 1.0 1.567517126098001 1.6791334471820518 22.222710888150825 -11.51478318604975 0.2822073167381435 1.2682359001057163e-24 1.7165595101861562 0.9993430056893496 0.00762165737797372 3.956636336171262 0.15315344087566468 2.450790333746694 0.043580982279624404 3.0564466100905796e-12 11.51478318604975 1.7165595101861562 PSDTIENVK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PSDTIENVKAK 11 1 M0R2S1 M0R2S1 UBA52 1 30230000.0 0.0 30230000.0 0.0 True False 0.0 24835220.311931945 0.0 0.0 PSDTIENVK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PSDTIENVKAK 11 1 M0R2S1 M0R2S1 UBA52 1 12981600.0 2618200.0 0.0 10363400.0 True False 3586219.294194582 0.0 7915778.360922711 1.0 0.0 2.207276720008973 21.774032279776364 -6.783522465715743 1.5220848120109693 0.4363698015224846 2.2267604894988633 0.7797016711241785 0.42356895002341843 0.2451227245353077 1.1218538717094328 0.2191312749788355 0.5155700589825579 1.646180808472963e-07 6.783522465715743 1.7903906879763787 PSDTIENVK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PSDTIENVKAK 11 1 M0R2S1 M0R2S1 UBA52 1 14434800.0 5054900.0 7951500.0 1428400.0 True False 4203373.320039413 7908663.69125083 1727071.8358246086 1.0 1.8815039943148981 0.41087757482564374 22.0031161635851 -6.744376945738088 1.6706670218833133 1.5218165584244807 0.409165372412162 0.6244211186574741 0.370356273043493 0.30995753159528233 1.7002658334864178 0.17525773844646494 0.42801868754051237 1.801453491208344e-07 6.744376945738088 -1.1126511860123187 PSDTIENVK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PSDTIENVKAK 11 1 M0R2S1 M0R2S1 UBA52 1 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 PSIEIYRPPASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PSIEIYRPPASR 12 1 Q6PJT7;Q6PJT7-5;Q6PJT7-9;Q6PJT7-2;Q6PJT7-11;Q6PJT7-10;Q6PJT7-3;Q6PJT7-4;G3V256;H0YJA2;G3V5I6;A0A3B3IT62;G3V3Y4;G3V3R9 Q6PJT7 ZC3H14 Zinc finger CCCH domain-containing protein 14 0 9059200.0 3126900.0 1717500.0 4214800.0 False True 4099396.180942671 1461255.6947625652 3778692.9272164586 1.0 0.3564563243620294 0.9217681727818594 21.966979993466456 -10.464976463642897 8.79439948659629 1.0000071147792347 0.6391122485719613 0.3520731061420328 0.23078759569636206 3.2195086975937424e-05 1.958716656300933e-06 0.2234635293916178 0.07448637622027181 3.427863631666353e-11 10.464976463642897 -0.3608948662072734 PSIEIYRPPASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PSIEIYRPPASR 12 1 Q6PJT7;Q6PJT7-5;Q6PJT7-9;Q6PJT7-2;Q6PJT7-11;Q6PJT7-10;Q6PJT7-3;Q6PJT7-4;G3V256;H0YJA2;G3V5I6;A0A3B3IT62;G3V3Y4;G3V3R9 Q6PJT7 ZC3H14 Zinc finger CCCH domain-containing protein 14 0 10229700.0 3126900.0 2005400.0 5097400.0 False True 4282999.43129518 1916794.79702902 3893499.1042483505 1.0 0.4475356179184411 0.9090589823101974 22.030190054989347 -10.11883897576149 7.530027071420132 1.0000000745226583 0.6782973001143224 0.393141122526833 0.18841612452206505 2.3574389585969105e-07 2.7617789460488398e-08 0.18243317024363806 0.06081104270257507 7.606082369112574e-11 10.11883897576149 -0.32170277440833583 PSK(ub)ASASGFADFTSFGNEEQQLAWAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PSKASASGFADFTSFGNEEQQLAWAK 26 1 Q9UBC2-2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 141938000.0 53660000.0 31197000.0 57081000.0 True False 51956592.67199904 43654124.790205754 42129773.706705965 1.0 0.8402037652044159 0.810864830430094 25.630803485751876 -13.999999999999991 0.23837646952000136 2.0494389643477686 0.7976912461717608 0.9995223025710563 0.0018165003337239558 13.566696168310653 0.15453716252178806 6.770931590976061 0.014474194699870907 1.0000000000000205e-14 13.999999999999991 -1.251747718176008 PSK(ub)ASASGFADFTSFGNEEQQLAWAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PSKASASGFADFTSFGNEEQQLAWAK 26 1 Q9UBC2-2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 201910000.0 54657000.0 109360000.0 37893000.0 True False 82918664.96193771 89843853.56641996 30403431.940908067 1.0 1.0835178497828097 0.36666571941147635 26.305193552628268 -6.877867941595258 1.0915718007555053 1.0504435307648516 0.31788536997517786 0.9719267935075551 0.05362679681480324 0.12953776665876623 0.28381350015092743 0.03791291640661938 0.09121031316587934 1.3247442965246418e-07 6.877867941595258 -0.7325581607896738 down PSK(ub)ASASGFADFTSFGNEEQQLAWAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PSKASASGFADFTSFGNEEQQLAWAK 26 1 Q9UBC2-2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 132178000.0 53660000.0 42585000.0 35933000.0 True False 44620667.5410622 42355586.152539335 43446424.164579704 1.0 0.9492369452689514 0.9736838680102243 25.411208761186153 -10.15042847166593 4.5094104481925426 1.0000056302724345 0.9614604066761911 0.7681768641659895 0.009980414419439776 5.706572989612752e-07 1.0751692157547888e-07 0.009664920531640404 0.0032211649024429592 7.072476748350119e-11 10.15042847166593 -0.03854522359624335 PSK(ub)ASASGFADFTSFGNEEQQLAWAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PSKASASGFADFTSFGNEEQQLAWAK 26 1 Q9UBC2-2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 172237000.0 54657000.0 97355000.0 20225000.0 True False 70754563.95054208 91937108.66807707 16544257.526024565 1.0 1.2993806128512322 0.23382601209427442 26.076319874720717 -6.831681356817678 1.320285760646004 1.1597960819841737 0.20413644811306694 0.9092098875599102 0.1352022943972148 0.17874780427663756 0.6087682548456843 0.08038682688882334 0.18499807276159969 1.47339313897862e-07 6.831681356817678 -0.9556596338711068 down PSK(ub)GPLQSVQVFGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PSKGPLQSVQVFGR 14 1 P62249;M0R210;M0R3H0;Q6IPX4 P62249 RPS16 40S ribosomal protein S16 1 20227800.0 5914800.0 8811600.0 5501400.0 True False 5727037.911597836 12330117.83188696 4060418.301537672 1.0 2.152965987341766 0.7089909939857235 22.449357723109017 -6.694029987808658 1.8519779611604161 1.720084256998514 0.7137086874387306 0.3893967449115624 0.48723140732510145 0.4080682303975715 2.716572675940711 0.2102193019576154 0.5446849966465827 2.0228794950761453e-07 6.694029987808658 -1.0063755695597834 PSK(ub)GPLQSVQVFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PSKGPLQSVQVFGR 14 1 P62249;M0R210;M0R3H0;Q6IPX4 P62249 RPS16 40S ribosomal protein S16 1 12239100.0 4048000.0 4701700.0 3489400.0 True False 5544654.993086733 4493963.347557272 2665275.586448818 1.0 0.8105036928646598 0.4806927734497413 22.40266626321016 -6.96266932041507 0.39602306871394505 1.0189448247818809 0.26028602434678205 0.9998567464212211 0.0025681562483281547 0.0787610262030852 0.017706501392858093 0.004247248214632794 0.02767486354019593 1.0897595399172943e-07 6.96266932041507 -0.7586588004350988 down PSQMEHAMETMMFTFHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PSQMEHAMETMMFTFHK 17 0 P60903 P60903 S100A10 Protein S100-A10 0 2876440.0 855930.0 971310.0 1049200.0 False True 1122132.5188379108 826394.3341367266 940638.8486370652 1.0 0.736449857983393 0.8382600386727924 20.097811631171798 -10.341636996613873 6.166949077842057 1.0000185166981894 0.7873549484019094 0.853298628556935 0.041563832218264624 1.0582532218174498e-05 1.1298007828010122e-06 0.04024750918377715 0.013414669165491472 4.553685191650771e-11 10.341636996613873 -0.21266356829627997 PSQMEHAMETMMFTFHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PSQMEHAMETMMFTFHK 17 0 P60903 P60903 S100A10 Protein S100-A10 0 3778330.0 855930.0 1617900.0 1304500.0 False True 1172390.4516385195 1546415.8283201628 996403.9670208292 1.0 1.319027996312073 0.8498908922605659 20.16102169269469 -6.723641018649757 1.7467201346184162 1.1933401350219102 0.8504935099724943 0.5294252201384273 0.13419162599631426 0.348285155697896 2.0787064908042963 0.06096150041777637 0.15235545541300244 1.8895525797813315e-07 6.723641018649757 -0.3428466250494159 PSQVVAETR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PSQVVAETR 9 0 P13639 P13639 EEF2 Elongation factor 2 0 17004300.0 1281900.0 7619100.0 8103300.0 False True 1680583.3139372577 6482359.979019183 7264848.24834229 1.0 3.8572083426392942 4.322813506533192 20.680530634507864 -9.860071259261668 0.4561501475188951 5.009968272437672e-19 4.336358258794155 0.998889527979553 0.04895241593812605 1.1587335407256427 0.20286563135493607 1.7877964381241438 0.10287439735648463 1.3801577890243317e-10 9.860071259261668 4.336358258794155 PSQVVAETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PSQVVAETR 9 0 P13639 P13639 EEF2 Elongation factor 2 0 9636500.0 2511000.0 1174100.0 5951400.0 False True 2431289.679451908 1642924.2528506157 4392549.801827044 1.0 0.6757418775458235 1.8066748026575215 21.21329036487549 -6.830045371404744 1.3276415089293274 0.8267410639183816 1.8371496833678198 0.9059770856335608 0.14580239724603425 0.18075550783225963 0.6230837128824 0.08622492634009417 0.19843450787726907 1.4789538715377702e-07 6.830045371404744 1.0104086194494382 PSQVVAETR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PSQVVAETR 9 0 P13639 P13639 EEF2 Elongation factor 2 0 15668600.0 1281900.0 6380800.0 8005900.0 False True 1755853.0720449304 6098875.157516098 6115071.306686128 1.0 3.4734541600414923 3.4826782514121715 20.743740696030756 -10.606894126256446 1.0035015251330304 9.996078023612232e-11 3.480184412584479 0.9999976931690666 0.0017742486710641693 2.2646140366913263 0.5954664407204902 5.771115388989687 0.0012126881023472036 2.4723267835475288e-11 10.606894126256446 3.480184412484518 PSSEVIK(ub)DANLYISGLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PSSEVIKDANLYISGLPR 18 1 Q15717;Q15717-2;M0QZR9;M0R055 Q15717 ELAVL1 ELAV-like protein 1 1 27514500.0 7667000.0 12118000.0 7729500.0 True False 7423615.281703613 16956780.594535165 5704912.069970456 1.0 2.284167477849664 0.7684816431733597 22.82369051610971 -6.682142687355118 1.8939532524213532 1.81091366709241 0.7741013990920673 0.33413517978957963 0.5440029508906498 0.43375986421868296 3.009952695123025 0.23030551139824143 0.6058244238418218 2.0790135154553147e-07 6.682142687355118 -1.0368122680003427 PSSEVIK(ub)DANLYISGLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PSSEVIKDANLYISGLPR 18 1 Q15717;Q15717-2;M0QZR9;M0R055 Q15717 ELAVL1 ELAV-like protein 1 1 20720900.0 7667000.0 8515100.0 4538800.0 True False 6375450.20568996 8469227.466184983 5487842.094959907 1.0 1.328412456053122 0.8607771871643072 22.604095791543987 -6.717950962665554 1.766589788016766 1.2002387451507377 0.8615848041035347 0.5028451502015523 0.13823331441976547 0.3593294793677143 2.1904538242142597 0.06215619830126973 0.15641841928265005 1.9144720809053474e-07 6.717950962665554 -0.33865394104720303 PSSEVIK(ub)DANLYISGLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PSSEVIKDANLYISGLPR 18 1 Q15717;Q15717-2;M0QZR9;M0R055 Q15717 ELAVL1 ELAV-like protein 1 1 35618200.0 7335100.0 8714100.0 19569000.0 True False 9495431.546437258 8229152.674690465 16007642.79489616 1.0 0.8666433573288296 1.6858257275207593 23.17880213849906 -6.865144134152335 1.1593794224868927 0.926386236905834 1.7295924893820054 0.9595971285029312 0.07213801260013915 0.14160106758470767 0.3587846374523014 0.04841523594729888 0.11376106791242947 1.364130332310279e-07 6.865144134152335 0.8032062524761714 PSSSWFWKPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PSSSWFWKPR 10 1 G3V1A6;P57764;E9PIB2;E9PNZ0;E9PQR9;E9PQ48 G3V1A6 GSDMD Gasdermin-D 0 15171700.0 2613700.0 3997400.0 8560600.0 False True 3426586.011106804 3401003.501743155 7674831.231073647 1.0 0.992534111421477 2.2397894598871133 21.708340470022456 -6.905552469647831 0.9254991077007175 0.9557435790363172 2.3865315436185224 0.9891319628102958 0.06111232177735539 0.1074327977089674 0.15526760709046947 0.04895830179623911 0.13132285427268947 1.2429324608574843e-07 6.905552469647831 1.4307879645822053 up PSSSWFWKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PSSSWFWKPR 10 1 G3V1A6;P57764;E9PIB2;E9PNZ0;E9PQR9;E9PQ48 G3V1A6 GSDMD Gasdermin-D 0 17856900.0 3322900.0 1474000.0 13060000.0 False True 3217416.358363499 2062575.8868084524 9639194.208398232 1.0 0.6410658917198884 2.9959424378948256 21.617471213203665 -6.86804073455821 1.1444916563061007 0.7992396819700981 3.128768469475419 0.9626840004751389 0.20011116107781274 0.1387429207297975 0.3408960091563264 0.13585678353229869 0.32057819071009996 1.3550623086103581e-07 6.86804073455821 2.3295287875053208 up PSSSWFWKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PSSSWFWKPR 10 1 G3V1A6;P57764;E9PIB2;E9PNZ0;E9PQR9;E9PQ48 G3V1A6 GSDMD Gasdermin-D 0 12654600.0 2613700.0 3028000.0 7012900.0 False True 3580055.522586657 2894212.947743033 5356597.455209177 1.0 0.808426832903393 1.4962330671729178 21.771550531545348 -6.832392813716782 1.3172887069725892 0.8977963347178968 1.5156487334028617 0.9105578057132264 0.08667982611527172 0.17787700669976828 0.6028260792829503 0.05165308008710826 0.11886065419503133 1.4709814169671903e-07 6.832392813716782 0.6178523986849649 PSSSWFWKPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PSSSWFWKPR 10 1 G3V1A6;P57764;E9PIB2;E9PNZ0;E9PQR9;E9PQ48 G3V1A6 GSDMD Gasdermin-D 0 9971100.0 3322900.0 3138900.0 3509300.0 False True 2763138.5794296567 3121990.1226771283 4243078.404830088 1.0 1.129870990155529 1.53560101415757 21.39787648863794 -6.950535808854614 0.5529283532729764 0.9944838332781363 1.6901448192863662 0.9992426740321486 0.006277779684273839 0.08327127195317456 0.03507720719818892 0.00678840156091896 0.03367777268803523 1.1206350226807374e-07 6.950535808854614 0.6956609860082299 PSWITTMYGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PSWITTMYGGK 11 0 P42785;P42785-2 P42785 PRCP Lysosomal Pro-X carboxypeptidase 0 4192400.0 0.0 1599200.0 2593200.0 False True 0.0 1360605.5936327768 2324880.5397308785 0.0 PTEAFISGLLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PTEAFISGLLDK 12 0 Q96C90;F5GXC4;F5H2U0;B5MC51;P53671-3 Q96C90 PPP1R14B;LIMK2 Protein phosphatase 1 regulatory subunit 14B 0 2318730.0 632870.0 566360.0 1119500.0 False True 829698.6987217974 481861.29565398936 1003664.8790022831 1.0 0.5807666040652187 1.2096739220496446 19.66222799791154 -6.727015543571703 1.7339324807950067 0.7468719688679818 1.2091117457375902 0.5454220277925084 0.17628148719043354 0.34187865178062515 2.0122355344803684 0.08060907287420181 0.2007190629479572 1.8749274024714238e-07 6.727015543571703 0.4622397768696084 PTGK(ub)QLADIGYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PTGKQLADIGYK 12 1 Q96I36 Q96I36 COX14 Cytochrome c oxidase assembly protein COX14 1 3160680.0 778660.0 1419700.0 962320.0 True False 1020830.8005541662 1207886.2939472552 862748.357625259 1.0 1.1832384889753957 0.8451433451624981 19.96131233325784 -6.759523305286743 1.6141943764945101 1.1065016090941178 0.843935601384545 0.6889868507653825 0.07706588348642762 0.28374992535711524 1.4570598600182492 0.03767041205235736 0.09057312462559265 1.7397093385447893e-07 6.759523305286743 -0.2625660077095727 PTGK(ub)QLADIGYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PTGKQLADIGYK 12 1 Q96I36 Q96I36 COX14 Cytochrome c oxidase assembly protein COX14 1 3986730.0 994530.0 1431600.0 1560600.0 True False 962959.1895281987 2003245.3456953776 1151832.0430035433 1.0 2.080301395406867 1.1961379625733493 19.87711513199373 -10.277144055424499 4.227276366948592 0.9994504863593351 1.6382196789717327 0.4099343731831817 0.3609582100715479 255664928.07119897 1305.4339023316643 1397004.4713757003 0.12356559621359521 5.2826999562010005e-11 10.277144055424499 0.6387691926123976 PTGK(ub)QLADIGYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PTGKQLADIGYK 12 1 Q96I36 Q96I36 COX14 Cytochrome c oxidase assembly protein COX14 1 2998660.0 778660.0 834900.0 1385100.0 True False 1066551.644495285 798011.3573549076 1057967.9070299366 1.0 0.7482163301454975 0.9919518782708262 20.024522394780732 -10.699098594261233 8.884493756279099 1.0002756167653721 0.8700841042353791 0.27473880823429375 0.09950462084743807 0.0005443651035229503 1.843652350266052e-05 0.09654628150907835 0.032114978284400936 1.9994079091703727e-11 10.699098594261233 -0.13019151252999306 PTGK(ub)QLADIGYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PTGKQLADIGYK 12 1 Q96I36 Q96I36 COX14 Cytochrome c oxidase assembly protein COX14 1 3149330.0 994530.0 2154800.0 0.0 True False 826995.7601493205 2143191.6647056895 0.0 1.0 2.591538878408179 0.0 19.657520407428006 -6.741227765054444 1.6867917196302948 1.9463369002133104 6.7416222053169784e-09 0.6073180606475842 0.6687155673086798 0.3162536055097024 1.7681129794187793 0.3138307411839474 0.7677133796526704 1.814563768085651e-07 6.741227765054444 -1.9463368934716883 PTWGNHTPIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PTWGNHTPIFR 11 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 8971700.0 0.0 0.0 8971700.0 False True 0.0 0.0 8043394.546623302 0.0 PTWGNHTPIFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PTWGNHTPIFR 11 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 20499000.0 0.0 0.0 20499000.0 False True 0.0 0.0 15657558.390157148 0.0 PVAVALDTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PVAVALDTK 9 0 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 93181000.0 30723000.0 33245000.0 29213000.0 False True 40278150.52195527 28284975.587994996 26190318.990883145 1.0 0.7022411709936162 0.6502363850248544 25.263494103910208 -13.999999999999998 0.24546518380351093 3.0243743662049676 0.6284051658687935 0.9995343741880358 0.0033250506899767255 13.822771225861228 0.15678671528331264 13.760435398235545 0.024620460819459605 1.0000000000000041e-14 13.999999999999998 -2.3959692003361743 PVAVALDTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PVAVALDTK 9 0 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 53806900.0 14793000.0 7734900.0 31279000.0 False True 14323404.312278809 10823485.906970637 23086091.55011393 1.0 0.7556503796860744 1.6117740620030718 23.771871089826266 -6.830445222488189 1.3261370950128306 0.8694808236627195 1.6349859182206592 0.9067195638937885 0.10997524606609113 0.18026559744231543 0.6198906097845411 0.06511324538072455 0.1498251260287408 1.4775928384473284e-07 6.830445222488189 0.7655050945579397 PVAVALDTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PVAVALDTK 9 0 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 51640400.0 8706700.0 34814000.0 8119700.0 False True 13208700.44503181 28601169.6969765 6514837.736009059 1.0 2.1653280590320496 0.4932232177662478 23.654985196372714 -6.719286146460861 1.7618218318941716 1.7094863715187136 0.49591497465513784 0.5092543689766948 0.49041419203561304 0.35666567089651 2.163229660262436 0.22105031348217402 0.5553984407701467 1.9085953154522505e-07 6.719286146460861 -1.2135713968635757 PVAVALDTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PVAVALDTK 9 0 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 69610000.0 30723000.0 17685000.0 21202000.0 False True 42082123.35785668 16903618.223525587 16194524.268896626 1.0 0.4016816851132038 0.3848314432991444 25.3267041654331 PVAVALDTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PVAVALDTK 9 0 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 32170600.0 14793000.0 9901000.0 7476600.0 False True 12301034.941016259 9847661.347805379 9039922.492107438 1.0 0.8005555138266933 0.7348912132559635 23.552276365260543 -13.999999999999998 0.15529375002021525 1.973104964350834 0.6668666096740617 0.9995495408792902 0.0023925780716662253 11.981642693763318 0.12435745278711823 3.513947251937228 0.06165307705873624 1.0000000000000041e-14 13.999999999999998 -1.3062383546767724 PVAVALDTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PVAVALDTK 9 0 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 27294800.0 8706700.0 13706000.0 4882100.0 False True 11270994.78471532 12943249.05145771 3993607.8945762464 1.0 1.1483679390048291 0.3543261239009717 23.426111518465163 -6.8584063251249825 1.193721887943174 1.0801857099572243 0.31702203580656857 0.9516747957450736 0.07577706061737213 0.14845682585452574 0.40288283114499057 0.04954093304974885 0.11544679288931302 1.3854589894031822e-07 6.8584063251249825 -0.7631636741506558 down PVAYSQK(ub)PGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PVAYSQKPGGR 11 1 A0A087WV34;Q8WWB7-2;Q8WWB7 A0A087WV34 GLMP Glycosylated lysosomal membrane protein 1 13302930.0 595230.0 7895300.0 4812400.0 True False 903007.4271418889 6486322.028739539 3861227.0306501477 1.0 7.183021793374849 4.275963756877756 19.784378328207957 -9.325976837017024 9.274648608126665 1.000000000625852 5.729492775151994 0.7792041953561423 1.1868014736801444 0.0 0.0 1.1491155857039677 0.38303852856798914 4.720882192942606e-10 9.325976837017024 4.7294927745261415 PVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGR 41 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 1423890000.0 566490000.0 468950000.0 388450000.0 False True 859406745.9664472 385262208.5769264 311672687.2363169 1.0 0.4482885553146074 0.36266027547389673 29.67876586077922 -13.999999999999998 0.2622590248326328 5.0868066918945996 0.33203431526066135 0.9995669774298527 0.005877216933508101 14.518138571460218 0.1620650998238003 31.48747335475443 0.03699520889411861 1.0000000000000041e-14 13.999999999999998 -4.754772376633938 PVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLALSGR 41 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 857613000.0 566490000.0 43093000.0 248030000.0 False True 733332472.1873245 40694836.66820853 202891085.00271347 1.0 0.05549302425791576 0.27666998625813805 29.449892182871668 -10.78466626407043 10.213838710381108 1.0052691378190977 0.16608150525805823 0.9498853150792562 0.09029511662658153 0.010737667046057234 0.00022637691849669705 0.08664926450163152 0.02914262357821724 1.6418509777589124e-11 10.78466626407043 -0.8391876325610395 PVFLALNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PVFLALNR 8 0 Q7L0X2-3;Q7L0X2-2;Q7L0X2 Q7L0X2-3 ERICH6 Glutamate-rich protein 6 0 23262450.0 2550900.0 809550.0 19902000.0 False True 3344254.6029507364 688768.2956011847 17842731.95346444 1.0 0.20595569936375768 5.335338983378018 21.673253255388897 -6.867367967535222 1.1478380869406035 0.5572732615887372 5.6212019343205855 0.9619897810694804 0.4395002997863967 0.13940838527940602 0.3449213348314392 0.2975909566812022 0.7015599820635404 1.3571630668546614e-07 6.867367967535222 5.063928672731848 up PVHGLIFLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PVHGLIFLFK 10 0 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 5442100.0 1239400.0 1880600.0 2322100.0 False True 1624865.402366675 1600021.810521387 2081831.3671560525 1.0 0.9847103693579158 1.2812331188317445 20.63188878507721 -6.894747036038711 0.9938884429628703 0.9858327841731362 1.3092399273064723 0.9837664342753137 0.017368839389939238 0.11537562109551666 0.20003022101555698 0.01322557883119786 0.03358755671912935 1.2742450757630134e-07 6.894747036038711 0.3234071431333361 PVHGLIFLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PVHGLIFLFK 10 0 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 7432800.0 2041700.0 2012400.0 3378700.0 False True 1976887.351070078 2815961.814527361 2493717.1111726733 1.0 1.424442223783311 1.2614361206888385 20.914799233672603 -10.096586954416429 5.1032906884297775 0.9999915891921489 1.3429391722368784 0.8551047566371028 0.06654696292629142 6.3683742065236134e-06 1.1273967789396551e-06 0.06443539956748795 0.021477939929116015 8.005953173096581e-11 10.096586954416429 0.3429475830447295 PVHGLIFLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PVHGLIFLFK 10 0 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 6960600.0 1239400.0 2075000.0 3646200.0 False True 1697639.6735256184 1983319.6388925985 2785042.655846185 1.0 1.1682806839532012 1.6405381538134494 20.6950988466001 -6.952940420711125 0.5255741223889271 0.9923070726125744 1.8377886537095274 0.9994122828166072 0.006573124938143021 0.08232610206275495 0.031239063181981237 0.007382130034621719 0.039031992503233255 1.1144474101137857e-07 6.952940420711125 0.8454815810969529 PVHGLIFLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PVHGLIFLFK 10 0 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 0 5552000.0 2041700.0 1470600.0 2039700.0 False True 1697764.0126460427 1462677.585908755 2466191.83949276 1.0 0.8615317411688478 1.452611682850485 20.69520450910688 -6.8449754328738495 1.2590803566635171 0.9263148665170617 1.4740490508581767 0.9326756746246216 0.06549316458749661 0.1630672093938315 0.4999895524783364 0.04075047254098844 0.09404562735427648 1.4289747903256678e-07 6.8449754328738495 0.547734184341115 PVHLTAFLGYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PVHLTAFLGYK 11 0 P39023;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 1941700.0 0.0 1941700.0 0.0 False True 0.0 1855909.2736567517 0.0 0.0 PVHLTAFLGYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PVHLTAFLGYK 11 0 P39023;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 5317800.0 3892000.0 0.0 1425800.0 False True 3236370.4448344014 0.0 1723928.1878456508 1.0 0.0 0.5326733194579834 21.62594532181938 -10.195165775506844 5.5662107988348914 1.0000243007606076 0.26633665972894116 0.7166624356978093 0.2174629720446139 6.558136197034668e-05 9.482544194159269e-06 0.21056457285715105 0.07018587242877022 6.380198997170584e-11 10.195165775506844 -0.7336876410316664 PVIACSVTIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PVIACSVTIK 10 0 P55769;B1AHD1;A0A3B3IUA2;A0A3B3IRU2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 0 48611000.0 14188000.0 13591000.0 20832000.0 False True 18600605.39678744 11563275.777303075 18676504.474654347 1.0 0.6216612594394482 1.0040804627724653 24.148846241928148 -10.958328908780285 10.980379269167651 1.0652494766951832 0.8128708611060084 0.2419983227682394 0.15612198600125668 0.0907081382888849 0.00034424157516167606 0.05498392727989711 0.05038815431330786 1.1007053850823688e-11 10.958328908780285 -0.25237861558917485 PVIACSVTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PVIACSVTIK 10 0 P55769;B1AHD1;A0A3B3IUA2;A0A3B3IRU2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 0 17206100.0 7191400.0 2460100.0 7554600.0 False True 6963112.94337334 3442430.7592520188 5575823.626857981 1.0 0.4943810027565492 0.8007659321631978 22.731300993779445 -10.312769738220519 6.092989579917331 1.000022897168121 0.6475734674598758 0.6382281215195933 0.1250811236541568 3.890761928406578e-05 4.3882950268932635e-06 0.12111713326733067 0.04036975906978815 4.866651658773828e-11 10.312769738220519 -0.35244942970824533 PVILLPEDTPPFLELK(ub)GSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PVILLPEDTPPFLELKGSR 19 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WYT6 P52701 MSH6 DNA mismatch repair protein Msh6 1 5529300.0 1471600.0 1192500.0 2865200.0 True False 1223700.6029337875 1186075.7658072817 3464300.0728120096 1.0 0.969253233154988 2.831002995754393 20.22281919312388 -6.9031459616492645 0.9411617108579925 0.929133993430925 3.039408411706619 0.9880676003454977 0.09508741273423678 0.10912661289203968 0.16464617928343062 0.07530216630098187 0.19920507842472707 1.249838902367455e-07 6.9031459616492645 2.110274418275694 up PVIVEPLEQLDDEDGLPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PVIVEPLEQLDDEDGLPEK 19 0 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 16894100.0 5738200.0 2470600.0 8685300.0 False True 5556043.9819318745 3457123.464008797 6410359.376585075 1.0 0.6222275193017337 1.1537632526724795 22.405626589137334 -6.715821953669448 1.7742176152384428 0.7691489563286085 1.1527537071674832 0.4927739876863313 0.1590549736826315 0.36350795937962 2.2338902913619543 0.0712439391641387 0.17974271154099983 1.923880294355294e-07 6.715821953669448 0.3836047508388747 PVLFSFQPNHFFNNNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PVLFSFQPNHFFNNNK 16 0 Q96RL7-4;Q96RL7-2;Q96RL7-3;Q96RL7 Q96RL7-4 VPS13A Vacuolar protein sorting-associated protein 13A 0 4543300.0 1987400.0 1091700.0 1464200.0 False True 1652611.1567481733 1085818.7954145174 1770357.450304111 1.0 0.657032231073081 1.0712486376938335 20.656315881841433 -6.686881361152801 1.8778330621770378 0.7843489793822721 1.0697517975646862 0.3556963827236703 0.14514540439423995 0.42341918650635 2.892412757183608 0.061895797050680205 0.16179745235661855 2.0564522927554622e-07 6.686881361152801 0.2854028181824141 PVLLLHPLGGWTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PVLLLHPLGGWTK 13 0 O43252 O43252 PAPSS1 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 0 13808600.0 4991900.0 6896100.0 1920600.0 False True 6544429.241628363 5867228.760787263 1721874.7356961009 1.0 0.8965226063514438 0.263105409520429 22.641835945424695 -6.935412572610753 0.7009396434310347 1.007977085831053 0.1131199100880552 0.9974991939261898 0.016289450696685647 0.08992312233251093 0.06461497519292791 0.015351429209817873 0.05570686746107823 1.16034578069042e-07 6.935412572610753 -0.8948571757429978 down PVLLLHPLGGWTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PVLLLHPLGGWTK 13 0 O43252 O43252 PAPSS1 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 0 27577800.0 8278000.0 8021800.0 11278000.0 False True 8015219.421148112 11224946.573134372 8323953.467252307 1.0 1.4004540591262433 1.0385184771473133 22.934310584834282 -10.571043719767875 6.984510469731806 0.9997785086000063 1.2194862681367613 0.32900889829427793 0.14775958260094155 0.0005101334651553002 3.133006838585301e-05 0.1432101600429523 0.0476892002213338 2.685074129705747e-11 10.571043719767875 0.21970775953675503 PVLLLHPLGGWTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PVLLLHPLGGWTK 13 0 O43252 O43252 PAPSS1 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 0 27379300.0 4991900.0 9125400.0 13262000.0 False True 6837540.331025111 8722209.65433761 10129788.739463571 1.0 1.2756355695279595 1.481496013047264 22.705046006947587 -6.974337701436183 0.11411874140520957 0.5944755003489127 2.167924210408606 0.9999995535457473 0.00013167496308221787 0.07491841413486115 0.0033831315121728486 0.01554575802650008 0.030715966231805038 1.0608703181751375e-07 6.974337701436183 1.5734487100596932 PVLLLHPLGGWTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PVLLLHPLGGWTK 13 0 O43252 O43252 PAPSS1 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 0 18716700.0 8278000.0 6105600.0 4333100.0 False True 6883523.777579437 6072707.920933288 5239131.176009247 1.0 0.8822091877873531 0.7611118004812887 22.71471586026856 -6.9707788217514235 0.2388569889700538 1.044103682519712 0.5957197062421291 0.9999878316420234 0.000340162459501639 0.07605083710808103 0.008120668990113962 0.002918254203148353 0.011829925784077221 1.0695994680124292e-07 6.9707788217514235 -0.448383976277583 PVLVLSQNTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PVLVLSQNTK 10 0 P49368;P49368-2;E9PRC8;Q5SZX9;E9PM09 P49368 CCT3 T-complex protein 1 subunit gamma 0 14002400.0 3168200.0 4573400.0 6260800.0 False True 4153540.880892444 3891066.546973576 5612992.473834296 1.0 0.9368070902765565 1.3513752807046573 21.985910323430094 -6.868026918264967 1.1444009945994735 0.9646492052351966 1.3747693988878633 0.9626782762499467 0.03523147910988746 0.13876512286004913 0.3408802500618739 0.023918707641610686 0.05644585304290126 1.3551054181519362e-07 6.868026918264967 0.4101201936526667 PVLVLSQNTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PVLVLSQNTK 10 0 P49368;P49368-2;E9PRC8;Q5SZX9;E9PM09 P49368 CCT3 T-complex protein 1 subunit gamma 0 10751200.0 3168200.0 2490000.0 5093000.0 False True 4339569.157385719 2379983.566671122 3890138.293627509 1.0 0.5484377550754121 0.8964342202051782 22.049120384952985 -9.801038790080622 6.183992084436885 1.0000000106904634 0.7224359876400642 0.4589428024866028 0.1420689619775197 2.1018366128145346e-08 3.9775652899449344e-09 0.13755768708691785 0.04585256031253783 1.581106812516781e-10 9.801038790080622 -0.2775640230503992 PVPLELHIQGFNISHTQTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PVPLELHIQGFNISHTQTR 19 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 14621700.0 4234800.0 6510100.0 3876800.0 False True 5551863.809861542 5538818.456171048 3475665.9248915175 1.0 0.9976502749099642 0.6260358762255368 22.40454074760648 -6.9082871954342515 0.9073220815713068 1.012138440239835 0.5797300607191244 0.9902589350546513 0.01734470038771343 0.10556151444254121 0.14499261202025224 0.014081159928208447 0.03842408965757412 1.235130381570883e-07 6.9082871954342515 -0.43240837952071065 PVPLELHIQGFNISHTQTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PVPLELHIQGFNISHTQTR 19 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 13912000.0 4634500.0 5450300.0 3827200.0 False True 4487380.334297046 7626633.212939023 2824741.506461081 1.0 1.699573614174994 0.6294856455272094 22.097442036188973 -6.730323261706662 1.722224843078377 1.4208500915843145 0.6301035779154153 0.5607078964138121 0.2940758820712783 0.3356219359586985 1.9504084201586092 0.1353125063498956 0.3356237759432176 1.8607016309229425e-07 6.730323261706662 -0.7907465136688993 PVPLELHIQGFNISHTQTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 PVPLELHIQGFNISHTQTR 19 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 23618000.0 5546900.0 9128900.0 8942200.0 False True 8415052.832708945 7499776.470578745 7174770.250494505 1.0 0.8912334384197137 0.8526114325279676 23.00454089866287 -13.999999999996234 0.1442300821278474 1.5218261552570413 0.8071657068721918 0.9995866130713126 0.0012687234852027062 11.94066247239487 0.11927790099596558 1.7499381509625653 0.04075422209182082 1.0000000000086713e-14 13.999999999996234 -0.7146604483848495 PVPLELHIQGFNISHTQTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PVPLELHIQGFNISHTQTR 19 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 28129400.0 4234800.0 7311600.0 16583000.0 False True 5800520.001166927 6988549.335772103 12666436.93760554 1.0 1.2048142811965432 2.1836726595300684 22.46775080912937 -6.94081839568488 0.6519152940272203 0.9891487908822795 2.4541095538245172 0.998269024404637 0.021490067955107404 0.08739544075421656 0.052926271118494045 0.021050904143106553 0.08394932498034353 1.1459920486016118e-07 6.94081839568488 1.4649607629422379 up PVQVIGALIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PVQVIGALIGK 11 0 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 0 2994290.0 763540.0 811150.0 1419600.0 False True 1001008.3341318781 690129.5818379349 1272713.409764752 1.0 0.6894344015991116 1.2714313821058338 19.93302255504721 -6.761737029959021 1.6058200466532029 0.8199954023761151 1.273749870817594 0.698046605222412 0.13065982943707588 0.28001669367743337 1.423484553025474 0.06418529884514501 0.1539908550908527 1.7308640990460683e-07 6.761737029959021 0.45375446844147893 PVQVIGALIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PVQVIGALIGK 11 0 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 0 2714930.0 763540.0 944690.0 1006700.0 False True 1045841.3718926492 902950.4721279265 768938.1936373088 1.0 0.863372301378617 0.7352340558547312 19.9962326165701 -6.971899720769433 0.20787306536301914 1.068935313077359 0.5261024603172764 0.9999936491409575 0.00027238274982961343 0.07569106037201401 0.006778344338963539 0.0039027528915175887 0.013344350490468723 1.0668424282686497e-07 6.971899720769433 -0.5428328527600825 PVSQARPPPNQKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 PVSQARPPPNQKK 13 2 A0A3B3IRP5;Q6P1J9;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 1 2490670.0 1268000.0 1025600.0 197070.0 True False 1662360.2793294655 872584.4777574879 176679.08682892364 1.0 0.5249069582614523 0.10628206714623224 20.664801657132365 -7.92643897850823 0.4271494138579946 1.0463219318246606 4.4168040962263817e-23 0.9969276084517885 0.020237267826544142 0.10372533021253884 0.09057032779237985 0.04029179243450135 0.08021590669002768 1.184570796003518e-08 7.92643897850823 -1.0463219318246606 down PVSSAASVYAGAGGSGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PVSSAASVYAGAGGSGSR 18 0 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 0 3042120.0 869380.0 1252400.0 920340.0 False True 1139765.599087897 1065546.801816965 825112.0453246644 1.0 0.9348824027235724 0.7239313469234063 20.120305723710224 -6.9497125707824425 0.5619961216059165 1.0027306754113001 0.6459668861133664 0.9991784899774054 0.0033772295673891242 0.08360148562381875 0.036442479677724245 0.0036115314293634266 0.01754343534016968 1.1227612858225412e-07 6.9497125707824425 -0.35676378929793373 PVTLLASLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PVTLLASLFK 10 0 Q96Q11-2;Q96Q11 Q96Q11-2 TRNT1 CCA tRNA nucleotidyltransferase 1, mitochondrial 0 4071040.0 1159600.0 1914900.0 996540.0 False True 1520246.8295823731 1629204.3842217382 893427.600286677 1.0 1.071670963240421 0.5876858829115996 20.535874150166993 -6.8692399903335 1.138164982615472 1.040350820620592 0.5597545729119157 0.963915844011607 0.04051361276219697 0.13758268312751998 0.333588625091102 0.027638411861972693 0.06534746822047714 1.351325616777365e-07 6.8692399903335 -0.48059624770867637 PVTLLASLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PVTLLASLFK 10 0 Q96Q11-2;Q96Q11 Q96Q11-2 TRNT1 CCA tRNA nucleotidyltransferase 1, mitochondrial 0 5257100.0 3153300.0 2103800.0 0.0 False True 3053200.2175291544 2943858.3111720686 0.0 1.0 0.9641877706776883 0.0 21.541890768552868 -7.052812650427222 1.0474118511751846 1.0116800826655157 1.3342335253168252e-19 0.9879903239258017 0.050760845040006684 0.0850883313483684 0.17961669683876225 0.040567521607447525 0.07259609455347796 8.854975207487126e-08 7.052812650427222 -1.0116800826655157 down PVTLLASLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PVTLLASLFK 10 0 Q96Q11-2;Q96Q11 Q96Q11-2 TRNT1 CCA tRNA nucleotidyltransferase 1, mitochondrial 0 10466600.0 2833300.0 4080100.0 3553200.0 False True 4298323.241975559 3351974.277033197 2850908.462577116 1.0 0.7798329926189058 0.6632606023521874 22.035342549544477 -13.999999999999662 0.07944299691169962 2.191234591377277 0.31153445132218494 0.9998889686531099 0.0014712361456578353 12.264008511198082 0.07914295835650471 2.57393384573271 0.31964698461784014 1.0000000000007772e-14 13.999999999999662 -1.8797001400550921 PVTLLASLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PVTLLASLFK 10 0 Q96Q11-2;Q96Q11 Q96Q11-2 TRNT1 CCA tRNA nucleotidyltransferase 1, mitochondrial 0 10275600.0 1159600.0 2913700.0 6202300.0 False True 1588335.4570117025 2784963.0996825895 4737444.480378146 1.0 1.7533847068567145 2.9826473113502003 20.599084211689885 -6.963821416054113 0.3777334417168255 0.9133799234772602 3.8659660835220495 0.9998867517507025 0.008695927934985947 0.07836320515206188 0.016284261131517826 0.016037000822420936 0.10398596637044755 1.0868724588381617e-07 6.963821416054113 2.952586160044789 PVTLLASLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PVTLLASLFK 10 0 Q96Q11-2;Q96Q11 Q96Q11-2 TRNT1 CCA tRNA nucleotidyltransferase 1, mitochondrial 0 6459300.0 3153300.0 1508200.0 1797800.0 False True 2622108.6648757234 1500075.027245739 2173711.6679119845 1.0 0.5720872850694142 0.828993739668302 21.322296043987144 -10.29567733895934 5.8109422330615645 1.0000241857623093 0.7005405123688567 0.6443319737901494 0.10488162089913357 3.286575133016622e-05 3.983361994262968e-06 0.10155938418566898 0.03385039758879787 5.062006063506104e-11 10.29567733895934 -0.2994836733934526 PVTLLASLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PVTLLASLFK 10 0 Q96Q11-2;Q96Q11 Q96Q11-2 TRNT1 CCA tRNA nucleotidyltransferase 1, mitochondrial 0 7853200.0 2833300.0 2817300.0 2202600.0 False True 3667762.702692627 2660514.7783942646 1801749.4005845094 1.0 0.7253781103235201 0.4912393594225125 21.806468871636927 -6.972977162819547 0.17285733450855373 1.1990764843161081 0.011253563688784426 0.999997263544866 0.0003438972266488833 0.07534795931669656 0.005408468779542075 0.009612851244059124 0.02687254440331006 1.0641989771786984e-07 6.972977162819547 -1.1878229206273236 down PVTQVTWHGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PVTQVTWHGR 10 0 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 3697200.0 1626200.0 1166700.0 904300.0 False True 2131963.948143204 992632.9077609795 810731.710658119 1.0 0.46559554096845557 0.3802745873654248 21.02375161141996 -13.999999999999998 0.2582305697012741 4.876272220185602 0.34855775767416275 0.9995587443032216 0.005760958272811581 14.339578226640127 0.16080283249500654 28.97478583033119 0.037651986571111414 1.0000000000000041e-14 13.999999999999998 -4.527714462511439 PVTVEPMDQLDDEEGLPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PVTVEPMDQLDDEEGLPEK 19 0 Q15233;Q15233-2;H7C367 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 11561600.0 3294800.0 1678500.0 6588300.0 False True 3190208.37748234 2348733.8032618673 4862626.585236606 1.0 0.7362320968874921 1.5242347865295591 21.605219230098676 -6.816434613482575 1.3871093002706594 0.8572939618751014 1.5401735346679648 0.8760073489930261 0.11532347920346145 0.19815849371504268 0.7500988033245226 0.06534663464115648 0.15078407267497396 1.526038134792942e-07 6.816434613482575 0.6828795727928634 PVTVEPMDQLDDEEGLPEK(ub)LVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PVTVEPMDQLDDEEGLPEKLVIK 23 1 Q15233;Q15233-2;H7C367 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 8099300.0 2129000.0 4324300.0 1646000.0 True False 2061416.0603556817 6051015.540926595 1214863.2210584588 1.0 2.9353683893791622 0.5893343146113081 20.975204286056286 -6.687582597216445 1.8750789217388921 2.216086469007405 0.5976834750653913 0.35913178563550596 0.8189293623803623 0.4218689373163472 2.87386856440397 0.349644024163883 0.9132568529571679 2.0531345095847514e-07 6.687582597216445 -1.6184029939420137 PWALTFSYGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PWALTFSYGR 10 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68;P09972;A8MVZ9 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 0 30977000.0 5091000.0 7941000.0 17945000.0 False True 6674350.301314128 6756233.753775564 16088223.540594874 1.0 1.0122683780090647 2.4104553723269855 22.67019597725678 -6.908821492495998 0.9037222162377733 0.9550793117425697 2.5866660837697495 0.9904691986046849 0.06463047197771542 0.10520251857609622 0.14303243936549526 0.052607420218871985 0.14406156338039805 1.2336117789047816e-07 6.908821492495998 1.63158677202718 up PWALTFSYGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PWALTFSYGR 10 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68;P09972;A8MVZ9 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 0 16514800.0 5091000.0 4622100.0 6801700.0 False True 6973280.279101912 4417880.338759267 5195278.545408638 1.0 0.6335440656241978 0.7450264921916687 22.73340603877967 -10.544232629430258 9.251414335265022 1.0000188742213585 0.6892852789079337 0.9119514598097862 0.04551251006293313 1.771889654433348e-05 8.729317057621789e-07 0.04406996788049106 0.0146890994598198 2.8560602875679984e-11 10.544232629430258 -0.3107335953134248 PWLGLDHFNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PWLGLDHFNK 10 0 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 0 18889100.0 4590700.0 4348500.0 9949900.0 False True 6018452.156402041 3699720.750320241 8920379.79418027 1.0 0.6147296105668493 1.482171754857492 22.52096106737035 -6.785974434462205 1.512466780013712 0.7835410554514552 1.4903909669858593 0.7879960968272389 0.1633947905059695 0.24140242554783745 1.0909727016511213 0.08505650555864445 0.1997301430789567 1.6369128784576188e-07 6.785974434462205 0.706849911534404 PWLGLDHFNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PWLGLDHFNK 10 0 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 0 15955000.0 6243800.0 2124200.0 7587000.0 False True 6045593.986683331 2972404.1375566586 5599737.094878812 1.0 0.49166453190604464 0.9262509369986455 22.527452662238318 -10.16210661049175 7.723219917260101 1.0000000983379493 0.7089577344523457 0.37421637246432826 0.17741915693789015 3.005129942797289e-07 3.248136210502629e-08 0.17178541890456628 0.05726178667655076 6.884832669126523e-11 10.16210661049175 -0.29104236388560367 PWLGLDHFNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PWLGLDHFNK 10 0 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 0 16020700.0 4590700.0 6019600.0 5410400.0 False True 6288005.849002784 5753634.167844767 4132574.950685698 1.0 0.9150173053285624 0.6572155067796389 22.584171128893242 -6.95119999387078 0.5455090837420916 1.0036639620421814 0.5565505773969333 0.999292128889511 0.003877772311630449 0.08300740284901549 0.03399542522687331 0.004233556496871149 0.02136935649603927 1.1189224977466523e-07 6.95119999387078 -0.4471133846452482 PWLGLDHFNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PWLGLDHFNK 10 0 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 0 10340700.0 6243800.0 2357500.0 1739400.0 False True 5191996.347239735 2344799.6795728863 2103100.4979230794 1.0 0.4516181296659564 0.40506586624260027 22.307857937672594 -13.999999999999998 0.3493339397268412 7.716225433985532 0.3985774704610282 0.9997534380775136 0.004241993094012565 20.593887464542686 0.19021685078226785 102.60431813788858 0.013921255469941858 1.0000000000000041e-14 13.999999999999998 -7.317647963524504 PWVSDFSHPHYLAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 PWVSDFSHPHYLAGR 15 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 11130400.0 3322600.0 4506100.0 3301700.0 False True 4355960.776104168 3833807.44464023 2960071.7561427727 1.0 0.8801290098091895 0.6795450896576177 22.054559532475693 -6.96337651862017 0.38490124488438765 1.0130410008463406 0.539484430750705 0.9998756648169886 0.0014741067809688221 0.07851629759360207 0.016829890778271284 0.0025987514527866557 0.016910510648861104 1.0879864369078894e-07 6.96337651862017 -0.4735565700956357 PWVSDFSHPHYLAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 PWVSDFSHPHYLAGR 15 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 6906600.0 2509900.0 1157800.0 3238900.0 False True 2430224.5983498013 1620115.5778472386 2390534.925082772 1.0 0.6666526126627752 0.9836683106187059 21.212658221407043 -10.607021384980571 9.061055125873501 1.0000480660857727 0.8251604618961481 0.2885404548834737 0.12942111674071705 0.00012570255245002228 5.451699397712235e-06 0.12534578344989833 0.04177048581536356 2.471602438492872e-11 10.607021384980571 -0.17488760418962457 PWWTGWFGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PWWTGWFGK 9 0 Q15637-6;Q15637-2 Q15637-6 SF1 Splicing factor 1 0 12003300.0 2375900.0 1317400.0 8310000.0 False True 2300478.3550019083 1843444.690150242 6133361.705343743 1.0 0.8013310301929413 2.6661245005883374 21.1335024516387 -6.880546803647375 1.0767075106255204 0.8759449657405295 2.7996947505220957 0.9741254182128237 0.13450568902910398 0.12714853169456344 0.2693481393417489 0.09618077639212155 0.23292348440060862 1.3165980161228165e-07 6.880546803647375 1.9237497847815663 up PWWTGWFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 PWWTGWFGK 9 0 Q15637-6;Q15637-2 Q15637-6 SF1 Splicing factor 1 0 5343710.0 2375900.0 704410.0 2263400.0 False True 1975666.1202163545 700615.203515562 2736666.475220818 1.0 0.3546222695962605 1.3851867211860305 20.913907727072978 -6.737378508972187 1.6960933820905593 0.614841332695559 1.3854759486491801 0.5931863221255327 0.27118325085138384 0.3225866512087858 1.8210482183021353 0.12653428053284954 0.3114258494255326 1.8307181660634018e-07 6.737378508972187 0.7706346159536211 PYIQVDIGGGQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 PYIQVDIGGGQTK 13 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 12322200.0 5142400.0 3562500.0 3617300.0 False True 6741736.199072435 3030988.8865162395 3243016.495591746 1.0 0.4495858035698964 0.48103580440272026 22.68468874578069 -9.916796598124922 5.125215913053539 1.0000014286726886 0.46531080397669516 0.997411939520144 0.012839409107892134 35378370.236252226 55609572.28030466 826.4630864884074 0.004698741377403225 1.2111652501323856e-10 9.916796598124922 -0.5346906246959935 PYIQVDIGGGQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 PYIQVDIGGGQTK 13 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 9209300.0 3108100.0 1941600.0 4159600.0 False True 3009435.066787925 2716891.005310238 3070075.9746748325 1.0 0.9027910371929275 1.0201502629367682 21.521061258024314 -6.686738037154455 1.8777342407219244 0.9388723582842164 1.0197326541207845 0.35534421145980544 0.04113993030604886 0.42370707466068397 2.8937996039140783 0.017542972112302102 0.04587645522561618 2.0571310662994113e-07 6.686738037154455 0.08086029583656806 PYIQVDIGGGQTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 PYIQVDIGGGQTK 13 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 14110900.0 3486700.0 6240300.0 4383900.0 False True 5289578.811914093 5126669.70931356 3517420.243468374 1.0 0.9692018762942711 0.6649717054117502 22.334721420178713 -6.926396652626468 0.7757992172041052 1.0052964962866981 0.6078841400647945 0.9957814021805955 0.009820442330607953 0.09455254712989103 0.08716615000491079 0.008762056390494832 0.028092722591042608 1.1846862486487106e-07 6.926396652626468 -0.39741235622190363 PYIQVDIGGGQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PYIQVDIGGGQTK 13 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 12990000.0 5142400.0 3394900.0 4452700.0 False True 7043684.248134683 3244902.09256698 3401063.966235067 1.0 0.4606825033967556 0.4828529852308103 22.74789880730358 -10.088329170295921 5.77667478030916 1.0000028602157065 0.47176774431376456 0.9986805635818804 0.00905106130769926 3.334091927440338e-07 5.262777679847472e-08 0.008763699948859099 0.0029212174758246256 8.159636832741535e-11 10.088329170295921 -0.5282351159019419 PYIQVDIGGGQTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PYIQVDIGGGQTK 13 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 8902800.0 3486700.0 5416100.0 0.0 False True 4513601.883132177 5114689.273865462 0.0 1.0 1.133172443271883 0.0 22.105847742271163 -6.94380764388388 1.21494628700362 1.0734791007150448 2.8124398128250913e-22 0.9697095370872335 0.08801706405421711 0.11032979642848982 0.324213961199527 0.06010049173163234 0.1148195838286182 1.1381312711241032e-07 6.94380764388388 -1.0734791007150448 down PYQYPALTPEQKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 PYQYPALTPEQKK 13 1 P04075;J3KPS3;H3BQN4;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 11803500.0 2889900.0 3585100.0 5328500.0 True False 3958374.1266110027 3426698.4276596904 4070018.04390225 1.0 0.8656833129094568 1.0282044884390027 21.91647654479657 -6.687234478352548 1.8763580490815839 0.9155730976847218 1.0276227039493 0.35742814192807415 0.05683906932678952 0.42265904476432264 2.882911708435432 0.02425370592150945 0.06337670566282129 2.054780907168517e-07 6.687234478352548 0.11204960626457816 PYQYPALTPEQKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 PYQYPALTPEQKK 13 1 P04075;J3KPS3;H3BQN4;H3BUH7;H3BR04;H3BMQ8 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 49865400.0 8904400.0 14746000.0 26215000.0 True False 11526921.331964936 13925372.137224237 21444138.9886148 1.0 1.2080738417645163 1.8603526797002377 23.458503906412535 -6.950458272278725 0.5537904822674855 0.9911752969344302 2.108094191344644 0.9992367520209332 0.010125561453383503 0.08330226137466841 0.035204940238907745 0.010937287074147714 0.05415188160145411 1.1208351126266484e-07 6.950458272278725 1.116918894410214 QAAEEQK(ub)TSGIM ddPTM_RPMI8226_Bortezomib_1h_R1 1 QAAEEQKTSGIM 12 1 Q96I36 Q96I36 COX14 Cytochrome c oxidase assembly protein COX14 1 2505120.0 550480.0 974050.0 980590.0 True False 721684.6108559025 828725.536817163 879127.9532834738 1.0 1.1483209207333827 1.218160869802734 19.46100896561642 -13.999999999997545 0.10034591224540869 0.2682485169780659 1.3661180498889178 0.9997919797682858 0.0013119599246171278 12.077769880586573 0.09440731499903238 1.8285707936617797 0.13193188740683867 1.0000000000056527e-14 13.999999999997545 1.0978695329108519 QAAEEQK(ub)TSGIM ddPTM_RPMI8226_Bortezomib_8h_R1 1 QAAEEQKTSGIM 12 1 Q96I36 Q96I36 COX14 Cytochrome c oxidase assembly protein COX14 1 9552600.0 2296400.0 2966400.0 4289800.0 True False 3483806.689327882 2437022.743411015 3441919.1497138645 1.0 0.6995286939646989 0.9879765029034665 21.732233142719792 -10.658191039329834 9.073332955051896 1.0001237275165784 0.843752598537334 0.2812105213405962 0.11775832488729887 0.00029496309479455765 1.111172629284791e-05 0.11410853641906232 0.038006335930482596 2.1968932813143002e-11 10.658191039329834 -0.15637112897924443 QAAEEQK(ub)TSGIM ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QAAEEQKTSGIM 12 1 Q96I36 Q96I36 COX14 Cytochrome c oxidase assembly protein COX14 1 2342780.0 550480.0 853170.0 939130.0 True False 754007.3321626439 815474.1283440955 717326.8359894765 1.0 1.0815201571119375 0.9513526001558097 19.52421902713931 -6.737380867503254 1.6962100290790718 1.048650720694807 0.9513179969632201 0.5931492659310502 0.03425410725393431 0.32258107928136603 1.821291675054865 0.015982333752815114 0.0393336778007413 1.8307082239754274e-07 6.737380867503254 -0.09733272373158697 QAAEEQK(ub)TSGIM ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QAAEEQKTSGIM 12 1 Q96I36 Q96I36 COX14 Cytochrome c oxidase assembly protein COX14 1 9086000.0 2296400.0 3194300.0 3595300.0 True False 2972735.0688114073 3016534.3969846317 2940992.2908932623 1.0 1.0147336803177476 0.9893220293153009 21.50335946481224 -6.749476245415116 1.6515096087309253 1.0086686932653426 0.9892726296476704 0.6468636253688176 0.006191050181416375 0.3009404403776499 1.6147353618075155 0.002961382913029644 0.007194158999187375 1.7804252900289642e-07 6.749476245415116 -0.01939606361767221 QAASSLQQASLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QAASSLQQASLK 12 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 14090450.0 741250.0 7289000.0 6060200.0 False True 971785.9282752118 6201509.612299461 5433148.637543215 1.0 6.381559386547507 5.5908904208834524 19.890279016426327 -10.514617243369704 5.653079248976003 0.9910078265784266 5.986224903715483 0.9814905696391889 0.32278925355519344 0.03614933174678497 0.003103836258398635 0.3088406114331564 0.1041797836128305 3.057614692749336e-11 10.514617243369704 4.995217077137056 QAASSLQQASLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAASSLQQASLK 12 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 13775500.0 4586400.0 1244400.0 7944700.0 False True 4440807.242468433 1741295.40946027 5863744.734108831 1.0 0.39211236029518964 1.3204231604633787 22.08239052041524 -6.73004087097748 1.723244484266521 0.6341954706066577 1.3198604231519278 0.5594290125210141 0.25553946799625404 0.33613848997366463 1.9555932733767891 0.11751744154747014 0.29157989360189007 1.8619119059297638e-07 6.73004087097748 0.68566495254527 QAASSLQQASLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QAASSLQQASLK 12 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 15002250.0 741250.0 7043300.0 7217700.0 False True 1015310.1565280494 6732103.716921562 5513027.913197582 1.0 6.630588371087154 5.429895365225057 19.953489077949218 -10.236770320403341 6.681709957367083 0.9999600246966571 6.030241868156099 0.9590197104153282 0.49018086701512065 0.00029198465274324066 3.335047652679025e-05 0.4746191641804939 0.15820519454825588 5.7973521228639964e-11 10.236770320403341 5.030281843459442 QADFEAHNILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QADFEAHNILR 11 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 10515700.0 2467800.0 3750500.0 4297400.0 False True 3235309.698209197 3190940.019334493 3852746.271571599 1.0 0.9862858016655213 1.190843112702368 21.625472389327136 -6.890858276825925 1.017267454991741 0.9892340033874999 1.208737271145242 0.9814428031274821 0.012718599645902657 0.11845049364323845 0.2177904291008424 0.00951534344081878 0.023796944003221198 1.285706155555792e-07 6.890858276825925 0.2195032677577421 QADFEAHNILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QADFEAHNILR 11 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 9220800.0 2467800.0 3195900.0 3557100.0 False True 3380212.3497874127 3054694.570571983 2716986.240774086 1.0 0.9036990148752334 0.8037915845567992 21.688682450850028 -6.970665301227754 0.24181865822470425 1.0350745409802806 0.669520055910656 0.9999870988861433 0.0002876687017056939 0.07608778125076372 0.008256202553821663 0.0023577317495006257 0.009708675488931479 1.0698790878726633e-07 6.970665301227754 -0.3655544850696246 QADFEAHNILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QADFEAHNILR 11 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 1306400.0 0.0 746130.0 560270.0 False True 0.0 742110.4495947913 677419.8666042106 0.0 QADFVQTPITGIFGGHIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QADFVQTPITGIFGGHIR 18 0 Q14694;Q14694-3;Q14694-2;H3BNA1 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 0 3309930.0 630930.0 1379200.0 1299800.0 False True 827155.3399348109 1173428.7360794926 1165309.1645620067 1.0 1.4186316395805072 1.4088153800153742 19.657798767688874 -10.0589433549842 4.681984924028131 0.9999838973767695 1.4137235098087977 0.9995779630138784 0.004007471225748044 2778206.746477422 0.1473059250371964 486.53145831114097 0.0013718639871184355 8.730852374424133e-11 10.0589433549842 0.41373961243202817 QADFVQTPITGIFGGHIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QADFVQTPITGIFGGHIR 18 0 Q14694;Q14694-3;Q14694-2;H3BNA1 Q14694 USP10 Ubiquitin carboxyl-terminal hydrolase 10 0 4095130.0 630930.0 1246300.0 2217900.0 False True 864201.8712421467 1191234.3450370338 1694077.6990843206 1.0 1.3784213905077898 1.9602800635566378 19.721008829211765 -6.964842844323734 0.36074425151133593 0.9502855921187375 2.4083783956022287 0.9999098629682119 0.0037497123561185137 0.07801438626997252 0.01504857642205604 0.00779483873582544 0.049675999694731424 1.084319219470503e-07 6.964842844323734 1.458092803483491 QADNPHVALYQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QADNPHVALYQAR 13 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 14635700.0 1853600.0 6492500.0 6289600.0 False True 2538926.0116565134 6205639.882173599 4804126.018378084 1.0 2.444198788654243 1.8921882702850596 21.27578692249331 -9.860222627948398 5.75083449487992 0.9999996743031091 2.1681935294723527 0.8565560702816869 0.22535735045185323 9.411199398210201e-07 1.8657815460385473e-07 0.21820137808058793 0.07273377210239379 1.3796768336408275e-10 9.860222627948398 1.1681938551692435 QADVNLVNAK(ub)LLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QADVNLVNAKLLVK 14 1 A0A2C9F2M7;O43175 A0A2C9F2M7 PHGDH D-3-phosphoglycerate dehydrogenase 1 10004000.0 2751900.0 4354800.0 2897300.0 True False 2664542.4408139046 6093694.349981996 2138410.2128631067 1.0 2.2869571362956527 0.8025431233926652 21.345456381841945 -6.677484293347203 1.9111341218048379 1.816138789459522 0.8083507688614573 0.3124413928743558 0.5457520120734975 0.44418058991696174 3.134495836045155 0.22934048904894433 0.6067581406366973 2.1014337679256102e-07 6.677484293347203 -1.0077880205980647 QADVNLVNAK(ub)LLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QADVNLVNAKLLVK 14 1 A0A2C9F2M7;O43175 A0A2C9F2M7 PHGDH D-3-phosphoglycerate dehydrogenase 1 9861600.0 4053500.0 1723700.0 4084400.0 True False 5247335.65643052 1627774.5797459236 3341081.10948306 1.0 0.3102097304850536 0.6367195331574839 22.3231536471607 -10.562650807115313 6.460839486587286 1.0007866555551943 0.4734646318217929 0.7761551291369331 0.1332970687607129 0.0015124627743108045 0.0001023818464363237 0.12923939104379023 0.04302144395070882 2.7374688934896586e-11 10.562650807115313 -0.5273220237334014 QAEEEK(ub)MALPELVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QAEEEKMALPELVR 14 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 23713700.0 3652100.0 8624600.0 11437000.0 True False 5540502.704273796 7085472.745692642 9176471.936984826 1.0 1.2788501556414904 1.6562525869550322 22.401585451024626 -6.966909686503199 0.3236063895036039 0.9504540647495587 1.9968865379425407 0.9999472701953045 0.001952755514368061 0.07731876472159625 0.012606070377549147 0.005639465057340268 0.03309315932846528 1.0791711173994935e-07 6.966909686503199 1.046432473192982 QAEILQESR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAEILQESR 9 0 E5RJD8;O75347;E5RIW3;O75347-2 E5RJD8 TBCA Tubulin-specific chaperone A 0 12146500.0 3604700.0 0.0 8541800.0 False True 3490270.771613018 0.0 6304446.331492802 1.0 0.0 1.806291472503499 21.734907532896685 -6.7564171771621515 1.6259133388954017 0.4165707010789188 1.8117589616838452 0.6762060878743368 0.42041422097351094 0.2889697511626836 1.5047374817319803 0.20409712542905756 0.4922369067042797 1.7521965578515356e-07 6.7564171771621515 1.3951882606049264 QAEVANQETK(ub)EDLPAENGETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QAEVANQETKEDLPAENGETK 21 1 A6NEL0;P05114;A6NL93 A6NEL0 HMGN1 Non-histone chromosomal protein HMG-14 1 20483900.0 7226700.0 8982700.0 4274500.0 True False 10963432.242538674 7379667.002844564 3429643.2014200925 1.0 0.6731164875732146 0.31282568501795477 23.386196187338037 -7.244540098254727 0.3021851771402494 1.0728700883632882 8.697029401383438e-12 0.9998942987749482 0.002885369520077478 0.09641684608443278 0.018372750734351937 0.011231870365527953 0.044042673873931425 5.6945564406396256e-08 7.244540098254727 -1.0728700883545912 down QAFPNTNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QAFPNTNR 8 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 8925990.0 247890.0 5594900.0 3083200.0 False True 324986.1905701746 4760162.728749391 2764180.0401427746 1.0 14.647276920898964 8.505530758993595 18.31001889036497 -9.35361713064419 9.534849103215585 0.9999956350771814 11.576403839946426 0.7981408357941949 2.5073573710626604 0.0 0.0 2.4277383352782103 0.8092461117594032 4.429787255635972e-10 9.35361713064419 10.576408204869244 QAFPNTNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAFPNTNR 8 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 7242030.0 2110400.0 937930.0 4193700.0 False True 2043406.5071745575 1312450.3402403337 3095244.1616967567 1.0 0.6422854853560559 1.514747139557947 20.962544805968175 -6.795377525461906 1.4747385970723699 0.8014624339625203 1.5254566638158786 0.8182942803936963 0.15264666803173832 0.227423709235177 0.9769003523767487 0.08144890322888318 0.18997594347597094 1.6018523198960664e-07 6.795377525461906 0.7239942298533584 QAFPNTNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QAFPNTNR 8 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 8240790.0 247890.0 4005100.0 3987800.0 False True 339541.63197536295 3828141.4389054226 3045963.7713190243 1.0 11.27443906255122 8.970810894671198 18.37322895188786 -9.600450026331208 9.33444121944996 0.9999941725121576 10.122624978611219 0.9543586988698848 0.9404522614074428 0.0 0.0 0.9105889865808113 0.30352966219360367 2.5092849028165885e-10 9.600450026331208 9.12263080609906 QAFYFALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QAFYFALR 8 0 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 13356100.0 3268500.0 4931200.0 5156400.0 False True 4285035.152199026 4195484.1816670485 4622865.191681438 1.0 0.9791014618664163 1.0788395024738693 22.030875608830023 -6.851996752462257 1.22535658036019 0.9888253100730221 1.0829841541811136 0.9431654215033294 0.010238592534638899 0.15527752834169772 0.4476445456353639 0.006534567590720982 0.015142499619280981 1.4060580382157845e-07 6.851996752462257 0.0941588441080915 QAFYFALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAFYFALR 8 0 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 8399000.0 4038500.0 1979200.0 2381300.0 False True 3910300.028063139 2769504.881391649 1757566.092531296 1.0 0.7082589216979978 0.44947090502460973 21.898847875678452 -7.05056059653476 0.19437807987665554 1.1707120002381435 3.212318964071703e-12 0.9999954067782294 0.00048193823042752245 0.07262129485762409 0.006389363123161295 0.009334928965556476 0.027627888876881095 8.901012346972199e-08 7.05056059653476 -1.1707120002349312 down QAFYFALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QAFYFALR 8 0 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 81054000.0 19489000.0 22011000.0 39554000.0 False True 29566237.836749267 18082965.077272043 31736134.562865954 1.0 0.6116085914318079 1.0733910326399263 24.817447343260852 -6.683680591423064 1.8886571831466872 0.7550716314622673 1.0716910341913704 0.3410079202476395 0.16447982562132749 0.4304609317899953 2.9717059786257582 0.0697973654497558 0.18323271314121065 2.0716644262005285e-07 6.683680591423064 0.31661940272910305 QAFYFALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QAFYFALR 8 0 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 13114400.0 3268500.0 3412600.0 6433300.0 False True 4476952.777891302 3261820.048040909 4913887.037972487 1.0 0.7285804005235154 1.0975963521971717 22.094085670352914 -6.709650841486094 1.7969660664561062 0.8330735186133422 1.0967014225937504 0.4632392023197476 0.11438108535999272 0.37576126038190444 2.365148349145704 0.050664038493775425 0.12874011316823844 1.9514128411631587e-07 6.709650841486094 0.26362790398040814 QAFYFALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QAFYFALR 8 0 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 72928000.0 19489000.0 33170000.0 20269000.0 False True 25228894.685623348 31324060.341226578 16580249.977502717 1.0 1.241594637083984 0.657192880786448 24.5885736653533 -6.794444958423505 1.4786230404891885 1.1342492267882078 0.650201387027397 0.8153905118895606 0.10302039383073848 0.22878008007343306 0.9879871507004108 0.054829225629194255 0.1279603071419119 1.605295697032148e-07 6.794444958423505 -0.4840478397608108 QAGEVTYADAHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QAGEVTYADAHK 12 0 Q08170;A0A0D9SEM4;A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247 Q08170;A0A590UJK4 SRSF4;SRSF6 Serine/arginine-rich splicing factor 4;Serine/arginine-rich splicing factor 6 0 11367860.0 569390.0 5148500.0 5649970.0 False True 746475.8039806037 4380363.868695811 5065365.30273919 1.0 5.868058743950433 6.785705947504238 19.509735972515415 -9.493042716258064 0.49870012450509743 2.6384808008044642e-14 6.779575527155568 0.9983656546775068 0.10264051087232358 0.8178728980472243 0.21389011575072858 1.746928551745902 0.1855423338562041 3.213344465542969e-10 9.493042716258064 6.779575527155542 QAGEVTYADAHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAGEVTYADAHK 12 0 Q08170;A0A0D9SEM4;A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247 Q08170;A0A590UJK4 SRSF4;SRSF6 Serine/arginine-rich splicing factor 4;Serine/arginine-rich splicing factor 6 0 8297690.0 3544290.0 1040300.0 3713100.0 False True 3431778.4539962593 1455697.2150928339 2740527.719387711 1.0 0.4241815824088802 0.7985736131061735 21.710524988817316 -10.140364397543161 7.43854031381927 1.0000001567089039 0.611377597757551 0.589595033291286 0.15284490649546412 3.973214905554655e-07 4.5951643269691514e-08 0.14799150389292304 0.04933048145079686 7.23828372417724e-11 10.140364397543161 -0.3886225589513529 QAGEVTYADAHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QAGEVTYADAHK 12 0 Q08170;A0A0D9SEM4;A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247 Q08170;A0A590UJK4 SRSF4;SRSF6 Serine/arginine-rich splicing factor 4;Serine/arginine-rich splicing factor 6 0 11418080.0 569390.0 5553690.0 5295000.0 False True 779908.8701861796 5308309.612203103 4044430.0539480955 1.0 6.8063203473194305 5.185772605692522 19.572946034038306 -9.79956439423138 7.149349639615909 0.9999999869295247 5.996046476506053 0.9268613786610853 0.6615858451345371 1.3636823367472833e-07 2.670271439113826e-08 0.6405777353003259 0.21352591335767732 1.586483668505423e-10 9.79956439423138 4.996046489576528 QAGEVTYADAHK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QAGEVTYADAHKER 14 1 A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247 A0A590UJK4 SRSF6 Serine/arginine-rich splicing factor 6 1 14756600.0 2146200.0 4093700.0 8516700.0 True False 2778298.207926769 3865881.996348491 6966747.9887215635 1.0 1.3914568224961361 2.5075594725018067 21.40577002825735 -6.952589336217103 0.5296609570728726 0.9823544057460981 2.96729862143542 0.999389097161298 0.015786867562373845 0.08246247541779618 0.031786797976153726 0.017621418726354973 0.09229159585322477 1.1153486957938986e-07 6.952589336217103 1.984944215689322 up QAGLEAAAK(ub)ATSSHPNSTSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QAGLEAAAKATSSHPNSTSLK 21 1 Q14258;A0A3B3IUA7 Q14258 TRIM25 E3 ubiquitin/ISG15 ligase TRIM25 1 9545000.0 3865300.0 1335000.0 4344700.0 True False 3214168.2118238485 1327808.090023246 5253156.682376914 1.0 0.4131109520462198 1.6343751590387552 21.61601400300854 -6.776038947499634 1.5513248911415238 0.6659722504937071 1.642868578057234 0.7530928503074379 0.24780510086764554 0.2567914007534429 1.2203533913808984 0.12585011524572973 0.29794909896363647 1.674792673998254e-07 6.776038947499634 0.976896327563527 QAGLSYIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QAGLSYIR 8 0 Q5VTU8;P56381 Q5VTU8 ATP5EP2;ATP5E ATP synthase subunit epsilon-like protein, mitochondrial;ATP synthase subunit epsilon, mitochondrial 0 4477050.0 730750.0 1984800.0 1761500.0 False True 958020.3265930655 1688675.5766898054 1579236.8775011369 1.0 1.7626719703277207 1.6484377561353591 19.86969674079901 -10.058199955762907 4.282519142925899 0.999935607795526 1.7055548633568212 0.9807186895216384 0.046635923101589205 3005732.0219315747 1766831.8405154648 1686.5548432021335 0.015964716746992156 8.745810121597308e-11 10.058199955762907 0.7056192555612951 QAGLSYIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QAGLSYIR 8 0 Q5VTU8;P56381 Q5VTU8 ATP5EP2;ATP5E ATP synthase subunit epsilon-like protein, mitochondrial;ATP synthase subunit epsilon, mitochondrial 0 4091850.0 730750.0 1806900.0 1554200.0 False True 1000928.022776217 1727065.1833807416 1187129.969753754 1.0 1.7254639135694088 1.1860293075430932 19.932906802321902 -10.025317233769988 5.308972804892536 0.99999695102235 1.4557466105571908 0.48763074780204374 0.22022325573058155 7.947579475882621e-06 1.4591432941212666e-06 0.21323167681834534 0.07107675015720163 9.433715315018587e-11 10.025317233769988 0.4557496595348408 QAGPASVPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAGPASVPLR 10 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 10060600.0 3106400.0 1208800.0 5745400.0 False True 3007789.032357388 1691480.143808726 4240507.381694578 1.0 0.5623666173431751 1.409842025513017 21.520271948625105 -6.766333702253212 1.588329836665522 0.7478145522259365 1.4139810173190879 0.716408010327888 0.18427918570785715 0.27239466586859135 1.3555876291870173 0.09147912920172806 0.21851286352476135 1.712640846539834e-07 6.766333702253212 0.6661664650931514 QAHLCVLASNCDEPMYVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QAHLCVLASNCDEPMYVK 18 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 138642000.0 42515000.0 54071000.0 42056000.0 False True 55737576.71584564 46003817.56710721 37704448.54963823 1.0 0.8253645077115235 0.676463721088169 25.732146944442466 -6.972976811909023 0.17288093985792738 1.1265628697023258 0.3712668212891275 0.9999972607294388 0.0002187616076998696 0.07534811520662646 0.005409343363673851 0.00611198909625179 0.017088300552255086 1.0641998370532487e-07 6.972976811909023 -0.7552960484131983 QAHLCVLASNCDEPMYVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAHLCVLASNCDEPMYVK 18 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 26047000.0 18382000.0 4047000.0 3618000.0 False True 17798473.471798074 5662988.204826192 2670337.2623265563 1.0 0.31817269125912817 0.15003181405179172 24.08525017455448 -13.99999999999964 0.19661998525898877 4.74249737666984 0.037123460017294 0.9994871085480427 0.00832315043595585 12.466070617009876 0.14061187456716573 17.917455139567103 0.10982558894139763 1.0000000000008304e-14 13.99999999999964 -4.705373916652547 QAHLCVLASNCDEPMYVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QAHLCVLASNCDEPMYVK 18 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 363618000.0 45201000.0 242130000.0 76287000.0 False True 68573221.63573836 198920009.7296753 61208841.01222002 1.0 2.9008409548896563 0.8926055908144727 26.031141967204604 -6.65858113149568 1.97782555342179 2.2249635641869094 0.9009780435126122 0.2296441889596864 0.8096078523201068 0.4878074147072185 3.6667004855791725 0.33088013142093214 0.8974125442968935 2.1949208729006385e-07 6.65858113149568 -1.3239855206742972 QAHLCVLASNCDEPMYVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QAHLCVLASNCDEPMYVK 18 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 156929000.0 42515000.0 44110000.0 70304000.0 False True 58233944.42467449 42161074.34773622 53699643.15632998 1.0 0.7239948240544052 0.9221364564406311 25.795357005965357 -10.490502955362999 5.344107369002318 1.0003349695024344 0.8230656402475172 0.5153140879405942 0.08089098269139948 0.00032344197502782676 3.083624483404266e-05 0.07846930629304295 0.026107452401844717 3.2321912083415765e-11 10.490502955362999 -0.17726932925491723 QAHLCVLASNCDEPMYVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QAHLCVLASNCDEPMYVK 18 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 32762000.0 18382000.0 0.0 14380000.0 False True 15285447.460674692 0.0 17386791.514392223 1.0 0.0 1.137473506034005 23.865655449988758 -10.692134005067103 4.416162561090156 1.0188432655166781 0.5687367530169325 0.16083744023169688 0.4643716142865565 0.08672611025908794 0.0060459720871540576 0.4526188469338436 0.14987529404857405 2.0317300075180403e-11 10.692134005067103 -0.45010651249974565 QAHLCVLASNCDEPMYVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QAHLCVLASNCDEPMYVK 18 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 199767000.0 45201000.0 88599000.0 65967000.0 False True 58513585.54491569 83668387.76521963 53961682.87857919 1.0 1.4298967835596885 0.9222077638219178 25.802268289297054 -6.682309096975951 1.8935271550327644 1.2714426889562236 0.9241004848864329 0.33465903027957467 0.18211086036578625 0.4334923179711444 3.006928026735651 0.07711293718501208 0.20279213635237703 2.0782170476413304e-07 6.682309096975951 -0.34734220406979066 QAHLTNQYMQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAHLTNQYMQR 11 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YB86 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 0 2234000.0 594810.0 251590.0 1387600.0 False True 575928.0821325324 352051.1990245174 1024145.9328922947 1.0 0.6112763206839139 1.7782531615755084 19.135529143693617 -6.816919203312804 1.3852658671817188 0.7898034748903036 1.8020596026788591 0.8771130174640153 0.1700819081829664 0.1975244836693759 0.7456310678971855 0.09650513602829862 0.2226198467095581 1.5243363168492578e-07 6.816919203312804 1.0122561277885556 QAIGIALETR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QAIGIALETR 10 0 Q99460;A0A087WW66;Q99460-2;H7BZR6;C9J9M4 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 28282300.0 8717800.0 10279000.0 9285500.0 False True 11429120.22329528 8745413.267228182 8324725.532805455 1.0 0.765186916959972 0.7283785077208019 23.446211018040472 -13.999999999999998 0.26084157798361796 2.726511645360072 0.7150333239231577 0.9995640542458177 0.0025119818367204307 14.454531051798174 0.1616221673893247 13.161122671470157 0.01602118134637809 1.0000000000000041e-14 13.999999999999998 -2.0114783214369143 QAIGIALETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAIGIALETR 10 0 Q99460;A0A087WW66;Q99460-2;H7BZR6;C9J9M4 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 16913300.0 5312800.0 3730200.0 7870300.0 False True 5144148.072079694 5219688.312736027 5808832.32606099 1.0 1.0146846940635972 1.1292117265420347 22.294500739941146 -6.930572477830848 0.7420780823782761 0.9982948357794739 1.153069991533482 0.9966495281580574 0.003343431994212874 0.09234179288261393 0.07623202061441164 0.003056456492876074 0.010330304495410723 1.1733498500502622e-07 6.930572477830848 0.15477515575400824 QAIGIALETR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QAIGIALETR 10 0 Q99460;A0A087WW66;Q99460-2;H7BZR6;C9J9M4 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 25022900.0 8717800.0 6872300.0 9432800.0 False True 11941006.249686627 6568659.062342946 7204966.914614096 1.0 0.5500925906068704 0.6033802146953218 23.509421079563364 -10.207733468949904 6.716494675127661 1.000002020020498 0.57673640265221 0.9882521086804564 0.021754581436991497 6.580290605268666e-07 7.762249203007531e-08 0.02106388332169838 0.0070212609674317255 6.19821349198009e-11 10.207733468949904 -0.42326561736828794 QAIGIALETR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QAIGIALETR 10 0 Q99460;A0A087WW66;Q99460-2;H7BZR6;C9J9M4 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 14058600.0 5312800.0 5013300.0 3732500.0 False True 4417828.596946611 4986292.357837857 4512948.492869895 1.0 1.1286749244377974 1.0215309158868286 22.074906015375422 -10.136513793957594 4.411808817962739 0.9999883555748701 1.0751029201657107 0.3958118531601654 0.043741358335880096 5.010747134295348e-06 9.806109018678556e-07 0.04235895387885092 0.01411746269633742 7.302746176970417e-11 10.136513793957594 0.07511456459084065 QAINYSK(ub)SLDMEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAINYSKSLDMEK 13 1 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 6234520.0 2526400.0 969820.0 2738300.0 True False 2446200.8148814416 1357074.183544489 2021057.0827608646 1.0 0.5547681021479267 0.8262024403171568 21.222111412576865 -10.302112082682488 6.039345441044044 1.0000188753541412 0.6904852712325417 0.6341942651497715 0.11081260453077986 2.8164529123993908e-05 3.2544720022310805e-06 0.10730037968077866 0.03576461432479802 4.987557520071848e-11 10.302112082682488 -0.3095336041215996 QAINYSK(ub)SLDMEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QAINYSKSLDMEK 13 1 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 18939700.0 1516700.0 5722000.0 11701000.0 True False 2300944.785622541 4700864.393809948 9388292.221269524 1.0 2.0430148620615802 4.080190137517549 21.133794933823037 -6.960505690155736 0.4282473125191759 0.9175598351566232 5.283541939765718 0.9997884970759326 0.01860254845660005 0.07952096884005393 0.020467496553066605 0.02652093433116921 0.16921855103358868 1.0952022058592052e-07 6.960505690155736 4.365982104609095 QAINYSK(ub)SLDMEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QAINYSKSLDMEK 13 1 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 7186800.0 2526400.0 1816200.0 2844200.0 True False 2100813.53849682 1806415.770112527 3438909.0699050347 1.0 0.8598648747308907 1.63694159757065 21.00251668801114 -6.860243838325964 1.184582699380362 0.9239259978855731 1.674733126693092 0.9539321730506437 0.07258107912350258 0.14654543563475728 0.39062461678116916 0.04778610582931059 0.11157185414592065 1.3796094536643433e-07 6.860243838325964 0.750807128807519 QAINYSK(ub)SLDMEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QAINYSKSLDMEK 13 1 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 31965700.0 1516700.0 5298000.0 25151000.0 True False 1963398.048626661 5003161.642683705 20573776.071052868 1.0 2.548215654071404 10.478657695235878 20.904921255915486 -6.939267729135849 0.6663429627733328 0.9097593680306668 12.571937425142782 0.9980663769706752 0.1825651647712133 0.0881023683414467 0.05614333119572367 0.17674220063808133 0.6847893480675681 1.1500911746714385e-07 6.939267729135849 11.662178057112115 QAITQVVVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QAITQVVVSR 10 0 Q9H9B4 Q9H9B4 SFXN1 Sideroflexin-1 0 3666800.0 2485300.0 1181500.0 0.0 False True 3258252.3676794395 1005224.8054509279 0.0 1.0 0.3085165579628994 0.0 21.63566692134567 -8.707112071723058 0.49409071363528073 1.072602171586601 4.150478114111443e-20 0.9947535269085015 0.030284654611138113 0.32431732697465426 0.19067298667070695 0.10965803991577619 0.061998316566540305 1.962853687896956e-09 8.707112071723058 -1.072602171586601 QAITQVVVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QAITQVVVSR 10 0 Q9H9B4 Q9H9B4 SFXN1 Sideroflexin-1 0 10556400.0 1736500.0 6443400.0 2376500.0 False True 2634397.4551549642 5293524.927486014 1906783.7333430476 1.0 2.009387352363135 0.7238026022276445 21.329041592717974 -6.697330237038352 1.8406083723066402 1.6284322369606108 0.727840685922743 0.4048158747037319 0.4262878736666265 0.40110320655130105 2.6399906201190086 0.18490856783913076 0.4770709556287648 2.00756568136889e-07 6.697330237038352 -0.9005915510378678 QAITQVVVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QAITQVVVSR 10 0 Q9H9B4 Q9H9B4 SFXN1 Sideroflexin-1 0 5880400.0 2485300.0 1718100.0 1677000.0 False True 3404182.572707132 1642188.6610030727 1280927.1388991426 1.0 0.48240322777316363 0.37628038788780416 21.698876982868562 -13.999999999999998 0.22274376988882033 4.1615026980758305 0.32098621578525366 0.9995007899458921 0.006087958768436416 13.075716284773911 0.14949120864460635 18.209950112351528 0.05768617194508706 1.0000000000000041e-14 13.999999999999998 -3.840516482290577 QAITQVVVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QAITQVVVSR 10 0 Q9H9B4 Q9H9B4 SFXN1 Sideroflexin-1 0 8489900.0 1736500.0 3076900.0 3676500.0 False True 2247933.4815323995 2905667.8101875237 3007414.724075617 1.0 1.2925951030395932 1.3378575250480653 21.100167914810424 -12.591927531096985 0.2854130358127733 1.2651169994210113e-08 1.3514642057764095 0.999515218346551 0.0032970130568931145 7.199714702003761 0.16355079850260856 4.182567114329872 0.01745471123205189 2.5590128630497977e-13 12.591927531096985 1.3514641931252396 QAK(ub)FIMNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QAKFIMNR 8 1 Q9UHA3 Q9UHA3 RSL24D1 Probable ribosome biogenesis protein RLP24 1 1606420.0 212900.0 966540.0 426980.0 True False 279113.961726533 822335.9995434106 382800.2054813709 1.0 2.946237423798632 1.3714835442607718 18.090494766557892 -6.593503001467436 2.2148741859110093 2.3143094451298865 1.376185121689063 0.00246708525861683 0.8426074960376916 0.6593648051974325 6.102899351091143 0.3169007217221372 0.9387591487857622 2.549746466098449e-07 6.593503001467436 -0.9381243234408234 QAK(ub)FIMNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QAKFIMNR 8 1 Q9UHA3 Q9UHA3 RSL24D1 Probable ribosome biogenesis protein RLP24 1 5171460.0 806260.0 2994300.0 1370900.0 True False 1223155.3655014348 2459943.7704273183 1099941.0141131852 1.0 2.0111457953821423 0.8992651670724287 20.222176236314873 -6.667268951920229 1.9465269031909609 1.646882956014633 0.9037512154542197 0.267300247723261 0.4297777031349457 0.46737302989145957 3.411216358130785 0.1778954795594737 0.4770827550990304 2.1514489626970737e-07 6.667268951920229 -0.7431317405604133 QAK(ub)FIMNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QAKFIMNR 8 1 Q9UHA3 Q9UHA3 RSL24D1 Probable ribosome biogenesis protein RLP24 1 1571550.0 212900.0 516750.0 841900.0 True False 291614.8834061676 493918.2763362654 643060.5594747693 1.0 1.6937348003885149 2.2051705727896627 18.153704828080784 -7.180584484110281 0.11733000290934778 8.382123256312141e-12 3.806738904951185 0.9999990373246386 0.00048454250465812976 0.08967381384828578 0.0049548036165792874 0.055871790819138324 0.10077118959367914 6.598048687146928e-08 7.180584484110281 3.8067389049428026 QAK(ub)FIMNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QAKFIMNR 8 1 Q9UHA3 Q9UHA3 RSL24D1 Probable ribosome biogenesis protein RLP24 1 4174800.0 965890.0 2439800.0 769110.0 True False 803180.3311821948 2426656.313137619 929927.3450371498 1.0 3.021309435660411 1.157806421465024 19.615364414475806 -6.6268653443635435 2.091609677695807 2.3346814222788854 1.1651731798582514 0.10639294074053895 0.8677195639121449 0.5672170949234061 4.724539090785446 0.33977416503365554 0.9615716792951913 2.3612102272378203e-07 6.6268653443635435 -1.169508242420634 QALDK(ub)LNGFQLENFTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QALDKLNGFQLENFTLK 17 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 5947300.0 1151000.0 3113000.0 1683300.0 True False 1508972.146299855 2648552.5343789584 1509128.2633537678 1.0 1.7552030638030425 1.0001034592018783 20.52513474512519 -10.215035082120071 4.032122945241955 0.9997431935280342 1.3776532615556298 0.25010275953239713 0.3082681228901941 108512625.31102839 121.42171685695517 260163.60386630963 0.10552837789026658 6.094876611023824e-11 10.215035082120071 0.37791006802759564 QALDK(ub)LNGFQLENFTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QALDKLNGFQLENFTLK 17 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 18252300.0 5561400.0 8193400.0 4497500.0 True False 5384856.401156451 11465067.348016541 3319469.8278921163 1.0 2.129131492820181 0.6164453758096925 22.360476442022765 -6.706851931971713 1.8062222929844984 1.6963641190502536 0.6202823788438855 0.4502843179270667 0.47604789146657694 0.38141154736083444 2.4235532769496544 0.2098877252742863 0.5352997280946246 1.9640297775092778e-07 6.706851931971713 -1.076081740206368 QALDK(ub)LNGFQLENFTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QALDKLNGFQLENFTLK 17 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 28784600.0 4400400.0 9734200.0 14650000.0 True False 6675728.512331649 7997055.9563482655 11754421.078676905 1.0 1.1979300748339021 1.7607697881907136 22.670493853881343 -6.952647753198222 0.5289800531453592 0.991057667387801 1.993148251986794 0.9993930098116797 0.007939878213455383 0.08243968534660963 0.031694945444499995 0.008871502544400835 0.046537757187829355 1.1151986802523884e-07 6.952647753198222 1.0020905845989931 QALDK(ub)LNGFQLENFTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QALDKLNGFQLENFTLK 17 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 8354300.0 1151000.0 2743100.0 4460200.0 True False 1576555.8046054416 2621900.771781345 3406792.6207024213 1.0 1.663056115186178 2.160908361600956 20.58834480664808 -6.974285449885053 0.11689882791340502 0.06061854104875127 3.7761105694128365 0.9999995060716015 0.00033415686148846645 0.07493487110903856 0.003472815536433581 0.03636876369133073 0.07305746105681785 1.0609979630261236e-07 6.974285449885053 3.715492028364085 QALDK(ub)LNGFQLENFTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QALDKLNGFQLENFTLK 17 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 13080300.0 5561400.0 4923800.0 2595100.0 True False 4624550.511793944 4897274.51210222 3137723.4116133004 1.0 1.0589730828137245 0.6784926240098786 22.14088171745704 -6.867314941846039 1.1481243107050192 1.032872010811386 0.6573104864862198 0.9619334416978924 0.0326223065111967 0.13945973926099484 0.34525401613003104 0.022084207844817468 0.052058081811402195 1.3573287813719466e-07 6.867314941846039 -0.3755615243251662 QALDK(ub)LNGFQLENFTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QALDKLNGFQLENFTLK 17 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 24686900.0 4400400.0 8051500.0 12235000.0 True False 5696404.544851813 7603426.947162677 10008355.541701399 1.0 1.3347765045996172 1.756960107537755 22.441620175973792 -6.967979660640164 0.3025774552575834 0.9289862235171303 2.1760278692440105 0.9999620574869328 0.0019077497460536052 0.07696386606525087 0.01136418160474506 0.006916166163154674 0.037761659641392296 1.0765156290206541e-07 6.967979660640164 1.2470416457268803 QALHSLELHYQAFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QALHSLELHYQAFLR 15 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 22564700.0 5753600.0 6375100.0 10436000.0 False True 8728631.844503094 5237413.59611636 8373320.025738706 1.0 0.6000268643950943 0.9592935267411756 23.05732410796297 -10.317080040265564 8.176839073007343 1.000000574071979 0.779660195568135 0.3340095161173372 0.1466700007234456 1.5349607474241451e-06 1.2810587767936235e-07 0.14201298785839 0.04733753918251124 4.8185898306073074e-11 10.317080040265564 -0.22034037850384403 QALHSLELHYQAFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QALHSLELHYQAFLR 15 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 19799400.0 5753600.0 8984300.0 5061500.0 False True 7448148.62041165 8484315.807165585 4140358.9353756956 1.0 1.1391174155567088 0.5558910202233401 22.82845043005542 -6.843772967810381 1.2648456326715616 1.0740087576318509 0.535241091795802 0.9307333122187308 0.06545863725895722 0.1644402823044821 0.5094051019490947 0.04055407621870544 0.09354045085132658 1.432936786887044e-07 6.843772967810381 -0.5387676658360488 QALPCVAESPTVHVEVHQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QALPCVAESPTVHVEVHQR 19 0 Q15645;Q15645-2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 57296000.0 21891000.0 18337000.0 17068000.0 False True 28699312.99274556 15601191.077066189 15301967.087816844 1.0 0.5436085205597 0.5331823480124692 24.774512866136124 QALPCVAESPTVHVEVHQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QALPCVAESPTVHVEVHQR 19 0 Q15645;Q15645-2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 18801300.0 5612400.0 4394300.0 8794600.0 False True 5434237.434072442 6148966.905971766 6491030.42765536 1.0 1.13152341622359 1.194469418460973 22.373646170856727 -13.999999999931823 0.09759520522799649 0.3456213095657579 1.333679774935854 0.9998056976937567 0.0011293498033982281 12.099142708464399 0.09253985121020604 1.6047592392487138 0.1243396226248262 1.0000000001569824e-14 13.999999999931823 0.9880584653700961 QALPCVAESPTVHVEVHQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QALPCVAESPTVHVEVHQR 19 0 Q15645;Q15645-2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 101482000.0 20637000.0 51404000.0 29441000.0 False True 31307837.76679129 42230554.57871484 23621973.44555128 1.0 1.3488812256306453 0.7545067028106129 24.90002053835899 -6.747623552893224 1.658485314536178 1.2057338047362343 0.7535272709900646 0.6386923429515456 0.1465892808913162 0.30423575153454085 1.6456671947717572 0.06984209241237907 0.16999320270636464 1.788036776283229e-07 6.747623552893224 -0.4522065337461697 QALPCVAESPTVHVEVHQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QALPCVAESPTVHVEVHQR 19 0 Q15645;Q15645-2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 57808000.0 21891000.0 18762000.0 17155000.0 False True 29984694.282031044 17933032.80236285 13103342.318315333 1.0 0.598072891245371 0.4370010310949805 24.837722927659016 -13.999999999988985 0.12607658164859165 2.9102757670955643 0.1997743370630617 0.9996637221660741 0.0043414991836837925 11.944584659101002 0.11001257728789904 5.676008509528667 0.2107152384345175 1.0000000000253635e-14 13.999999999988985 -2.7105014300325028 QALPCVAESPTVHVEVHQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QALPCVAESPTVHVEVHQR 19 0 Q15645;Q15645-2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 17809400.0 5612400.0 4405400.0 7791600.0 False True 4666959.271477029 4381667.23579657 9420787.535712002 1.0 0.9388698252791549 2.0186136170694398 22.154051446291003 -6.893490649305017 1.0015301056308719 0.9467450187323687 2.1180808622498253 0.9830392368582034 0.06449381634845588 0.11635567558713018 0.2056815535510525 0.04882820870089782 0.12336010257764538 1.277936724232886e-07 6.893490649305017 1.1713358435174566 up QALPCVAESPTVHVEVHQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QALPCVAESPTVHVEVHQR 19 0 Q15645;Q15645-2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 70575000.0 20637000.0 31461000.0 18477000.0 False True 26715003.316086497 29710167.69355834 15114375.590029955 1.0 1.1121154409765055 0.5657635678049421 24.67114686045144 -6.853227281887451 1.2194470119886518 1.0600344205130101 0.5425275231243613 0.9448715179432077 0.05532121054724912 0.15393798643314496 0.43889184531103553 0.035467690531591115 0.08226029532541768 1.4020797538771736e-07 6.853227281887451 -0.5175068973886489 QALQK(ub)QALQEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QALQKQALQEK 11 1 P27469 P27469 G0S2 G0/G1 switch protein 2 1 16261000.0 1431600.0 6447400.0 8382000.0 True False 2171841.8639791845 5296811.096233872 6725294.026038893 1.0 2.438856706873313 3.0965855008048364 21.050487630864907 -9.340989750092774 0.24228892673116378 5.2125303287911885e-21 3.544416630492018 0.9991694204359407 0.02523186854134881 0.7554600361761342 0.09232885636150334 0.89224370630666 0.2957172834684512 4.560476791348858e-10 9.340989750092774 3.544416630492018 QALQK(ub)QALQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QALQKQALQEK 11 1 P27469 P27469 G0S2 G0/G1 switch protein 2 1 11545700.0 1431600.0 7906400.0 2207700.0 True False 1853234.4210548745 7466401.889715833 1805921.25291493 1.0 4.028849132570019 0.9744699496175915 20.821613952957357 -6.648083522966153 2.015226738959916 2.968368346319431 0.9872552082752892 0.18639347817619234 1.2933514321939232 0.5132281217043189 3.9928395473238854 0.5208731068446213 1.4325674944811024 2.2486221120846827e-07 6.648083522966153 -1.9811131380441416 QALVAIFTHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QALVAIFTHLR 11 0 Q14204 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 48570000.0 9833000.0 15913000.0 22824000.0 False True 14917379.8885913 13073200.821163526 18312826.39588545 1.0 0.876373794781603 1.2276168155971519 23.8304908248931 -6.811599794722064 1.4078646499211145 0.9327506810085818 1.2339848549665677 0.8639392401109426 0.053660192275822985 0.20463323693050212 0.799105094557362 0.029967460433999747 0.06926983953739678 1.5431217950448666e-07 6.811599794722064 0.3012341739579859 QALVAIFTHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QALVAIFTHLR 11 0 Q14204 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 27698000.0 9833000.0 17865000.0 0.0 False True 12729012.337407494 16870797.045402877 0.0 1.0 1.3253814670148192 0.0 23.60161714698555 -6.87601305313562 1.348474782178509 1.1702149408274611 1.2795322114369892e-20 0.9263985048240129 0.1530014349263401 0.15199666031024195 0.5556621069201972 0.09193142655445709 0.1882068559139297 1.33041443050025e-07 6.87601305313562 -1.1702149408274611 down QALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQK 40 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;B4DVF8;M0R1W6;M0QYL7 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 48359200.0 9510200.0 26870000.0 11979000.0 False True 14427668.68875022 22074838.56373176 9611345.399417777 1.0 1.5300350347623601 0.6661745294242924 23.78233486335449 -6.74068859189496 1.6841206936427098 1.3151244366241093 0.6655901912886275 0.6080010078611117 0.22269621111781007 0.3165979055209087 1.7633931636441742 0.10459638851308985 0.25648180471407933 1.816817933606395e-07 6.74068859189496 -0.6495342453354818 QAMFLNLVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QAMFLNLVYK 10 0 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 0 3779080.0 863480.0 1565800.0 1349800.0 False True 1132030.6419522152 1332188.7434405945 1210135.6441958754 1.0 1.1768133247199049 1.0689954841760874 20.11048157907895 -10.139343641292927 4.723207248104877 0.9999894194320863 1.1229044044491454 0.6340449824509629 0.04401644908746311 4.904531440400499e-06 8.93755772717214e-07 0.04262241210961834 0.014206247855685313 7.255316436724145e-11 10.139343641292927 0.12291498501705911 QAMFLNLVYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QAMFLNLVYK 10 0 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 0 12611000.0 2798700.0 3798600.0 6013700.0 False True 4245832.512376741 3120710.1514027333 4825089.55910166 1.0 0.7350054770897724 1.136429556520745 22.017616030927957 -6.728665807358391 1.728018790401409 0.8402931814818251 1.1361370042396743 0.5531240196911256 0.11140938234681429 0.33873444513163387 1.9809457899006049 0.0511039771730612 0.127006726813615 1.8678164357833868e-07 6.728665807358391 0.29584382275784926 QAMFLNLVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QAMFLNLVYK 10 0 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 0 4980480.0 863480.0 1699600.0 2417400.0 False True 1182731.8906695982 1624506.0521743929 1846459.9079157931 1.0 1.3735201231909677 1.561182143207814 20.17369164060184 -11.326833066135947 0.12008193558575038 2.054625134726457e-19 1.9146159955390727 0.9997899532645845 0.0033805181138357497 3.9760050097805926 0.07671631504176728 1.3113595463146468 0.24720292317454132 4.711583951890787e-12 11.326833066135947 1.9146159955390727 QAMFLNLVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QAMFLNLVYK 10 0 Q03701 Q03701 CEBPZ CCAAT/enhancer-binding protein zeta 0 9163800.0 2798700.0 3027500.0 3337600.0 False True 3622972.3206246686 2859016.963613613 2730191.046667969 1.0 0.789135745624649 0.7535776718816424 21.788742353020407 -13.999999999999998 0.25045106957624147 2.469802809987078 0.7393415515144502 0.9995435357103863 0.002323581300827051 14.015903157170143 0.15835905517167873 10.366783373008552 0.016368779961302208 1.0000000000000041e-14 13.999999999999998 -1.7304612584726278 QANGGAYQK(ub)PTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QANGGAYQKPTK 12 1 P18827 P18827 SDC1 Syndecan-1 1 11275300.0 3617400.0 4357500.0 3300400.0 True False 4742446.430951431 3707377.985401964 2958906.2676722948 1.0 0.781743777052678 0.6239198082156677 22.17720004686452 -7.01986135927425 0.09760883023644987 1.408791677871189 2.822941834886917e-08 0.9999997850312738 7.125783732439607e-05 0.07194322643810876 0.0028488877486417138 0.01479282238290577 0.02596120568370611 9.552974989463747e-08 7.01986135927425 -1.4087916496417707 QANGGAYQK(ub)PTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QANGGAYQKPTK 12 1 P18827 P18827 SDC1 Syndecan-1 1 10582900.0 3617400.0 3199900.0 3765600.0 True False 4954850.536559275 3058517.8373457496 2876242.8349663764 1.0 0.6172775172083458 0.5804903324013652 22.24041010838741 -13.999999999999998 0.33122823781946137 5.197155839969564 0.5740686564981475 0.9997173852280044 0.0031887910404332876 18.92715254053395 0.18410071468274408 55.37621980175322 0.011734553661721532 1.0000000000000041e-14 13.999999999999998 -4.623087183471416 QANGGAYQKPTK(ub)QEEFYA ddPTM_RPMI8226_Bortezomib_1h_R1 1 QANGGAYQKPTKQEEFYA 18 2 P18827 P18827 SDC1 Syndecan-1 1 17449700.0 7460300.0 6308300.0 3681100.0 True False 9780525.545647979 5367126.229560806 3300215.0836045602 1.0 0.5487564246431529 0.33742717282437346 23.22148055819587 -11.70979485240035 0.12990730369808368 2.235851157691505 1.6156345672691581e-15 0.9997256587604528 0.004577116099884868 4.770571595697425 0.08677020979157288 1.895176055651848 0.2490724301965413 1.950765865042879e-12 11.70979485240035 -2.235851157691503 QANGGAYQKPTK(ub)QEEFYA ddPTM_RPMI8226_Bortezomib_2h_R1 1 QANGGAYQKPTKQEEFYA 18 2 P18827 P18827 SDC1 Syndecan-1 1 14698600.0 5361700.0 3999700.0 5337200.0 True False 5191495.768346197 5596801.068159954 3939227.2074320875 1.0 1.0780710064881496 0.7587846322538693 22.30771883559021 -6.842055647983892 1.272782634638493 1.0415270736051605 0.7478460910085052 0.9279395249222435 0.0364815939521266 0.16640794522407285 0.5227596139768778 0.022467315299330708 0.05179332113574862 1.43861423073579e-07 6.842055647983892 -0.2936809825966553 QANGGAYQKPTK(ub)QEEFYA ddPTM_RPMI8226_Bortezomib_8h_R1 1 QANGGAYQKPTKQEEFYA 18 2 P18827 P18827 SDC1 Syndecan-1 1 26466900.0 12652000.0 6460700.0 7354200.0 True False 19194008.985096805 5307737.607320504 5900639.146539633 1.0 0.27653095356169205 0.3074208807092456 24.194152737853276 -10.694786238294943 6.756513651259247 1.0061357415881451 0.2919759171355254 0.9985744596443845 0.012610759950542016 0.0011650234610888946 5.2627833988549576e-05 0.012204744981517942 0.004070105272622389 2.0193600572499002e-11 10.694786238294943 -0.7141598244526197 QANGGAYQKPTK(ub)QEEFYA ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QANGGAYQKPTKQEEFYA 18 2 P18827 P18827 SDC1 Syndecan-1 1 16793900.0 7460300.0 4709500.0 4624100.0 True False 10218574.517026925 4501418.717766122 3531982.8163288715 1.0 0.4405133720232243 0.34564339775999353 23.284690619718763 -13.999999999999998 0.24966445579740384 4.884398812290092 0.30737573859731787 0.9995420594310531 0.006178371347596001 13.984737472672917 0.1581117960397666 27.237826153607724 0.04386385129647961 1.0000000000000041e-14 13.999999999999998 -4.577023073692774 QANGGAYQKPTK(ub)QEEFYA ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QANGGAYQKPTKQEEFYA 18 2 P18827 P18827 SDC1 Syndecan-1 1 14411300.0 5361700.0 6626300.0 2423300.0 True False 4458491.113583916 6590602.806682436 2930000.8259267523 1.0 1.478213736167939 0.657173189602143 22.088124111024488 -6.748840760841813 1.6543695019746838 1.281591919018853 0.6557087578353513 0.6438564590149892 0.20093740815786534 0.3020791627275846 1.6263544568787995 0.09596649350043339 0.23324355787343778 1.783032417325017e-07 6.748840760841813 -0.6258831611835016 QANGGAYQKPTK(ub)QEEFYA ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QANGGAYQKPTKQEEFYA 18 2 P18827 P18827 SDC1 Syndecan-1 1 27686100.0 12652000.0 7999300.0 7034800.0 True False 16378263.408204962 7554131.923050165 5754538.583143526 1.0 0.4612291141480725 0.35135218183514466 23.965279059945725 -13.999999999999936 0.22349799675277932 4.301931451783649 0.2945131327426844 0.9995016374827874 0.006327726912712794 13.09714113815002 0.1497380116584986 19.122251077304547 0.05943581308523124 1.0000000000001472e-14 13.999999999999936 -4.007418319040965 QAPGQTQGGQPWTYHLVQFADLLLNHSHNVTTVTPFTAQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QAPGQTQGGQPWTYHLVQFADLLLNHSHNVTTVTPFTAQQR 41 0 I3L1L3;Q9BQG0;Q9BQG0-2;I3L2H8 I3L1L3 MYBBP1A Myb-binding protein 1A 0 1545030000.0 590380000.0 372520000.0 582130000.0 False True 895649622.5593957 306040895.4879554 467071750.3433568 1.0 0.34169711880569686 0.5214893621108879 29.738359220559985 -10.836979362706952 10.91688255039645 1.0094402193018837 0.4315932404592787 0.9301991608114004 0.07339987596800716 0.016230849595336844 0.00024237306933983882 0.06839809178523802 0.023689708103148473 1.4555282443648095e-11 10.836979362706952 -0.5778469788426049 QAPGQTQGGQPWTYHLVQFADLLLNHSHNVTTVTPFTAQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QAPGQTQGGQPWTYHLVQFADLLLNHSHNVTTVTPFTAQQR 41 0 I3L1L3;Q9BQG0;Q9BQG0-2;I3L2H8 I3L1L3 MYBBP1A Myb-binding protein 1A 0 1885840000.0 590380000.0 768320000.0 527140000.0 False True 764258548.1296289 725562316.5924395 431205928.91315687 1.0 0.9493676169774081 0.5642147280765754 29.509485542652435 -6.93104676460677 0.738153625306623 1.005635594287506 0.48299619958033446 0.9967398932779715 0.011111023507554602 0.0920981710750147 0.07504537099196333 0.010186393078640246 0.03465134595387307 1.1720691509486577e-07 6.93104676460677 -0.5226393947071715 QAQGAQSTSDEK(ub)RPVGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QAQGAQSTSDEKRPVGQK 18 2 O60331-4;O60331;O60331-2;O60331-3 O60331-4 PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1 7659140.0 1409900.0 1943800.0 4305440.0 True False 1848392.5534910217 1653792.616873056 3859954.3694967274 1.0 0.8947193677823313 2.0882763037572887 20.81783975185339 -6.885397228758667 1.049205821080909 0.9286157897502199 2.1821409670243663 0.9777858342948657 0.0804164715787398 0.12295804954679428 0.2442886447613807 0.058723016147246426 0.14417314152285698 1.3019753779672335e-07 6.885397228758667 1.2535251772741465 up QAQGAQSTSDEK(ub)RPVGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAQGAQSTSDEKRPVGQK 18 2 O60331-4;O60331;O60331-2;O60331-3 O60331-4 PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1 6572500.0 2034700.0 3253700.0 1284100.0 True False 1970109.56223847 4552919.377821343 947755.6878257414 1.0 2.3109980607617797 0.48106750304226037 20.90984443276362 -6.714320553449596 1.7793148856789645 1.8023204879442671 0.484663045021573 0.48598177122385045 0.5520805866264822 0.3663651469774351 2.2634713506859794 0.24664982435579894 0.623460080222833 1.9305428542544017e-07 6.714320553449596 -1.3176574429226942 QAQGAQSTSDEK(ub)RPVGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QAQGAQSTSDEKRPVGQK 18 2 O60331-4;O60331;O60331-2;O60331-3 O60331-4 PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1 25457500.0 19050700.0 3636800.0 2770000.0 True False 28901304.692727175 2987784.6255519087 2222508.285865873 1.0 0.10337888400947398 0.076899929241781 24.784631286046174 -12.917792848815816 0.5161157942709635 9.999999999639902 0.07859689420016412 0.999938378596552 0.0033679965858442887 16.552778054397624 0.25714457034749794 166.89795571688032 0.0052378162791700605 1.2083900794680378e-13 12.917792848815816 -9.921403105439738 QAQGAQSTSDEK(ub)RPVGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QAQGAQSTSDEKRPVGQK 18 2 O60331-4;O60331;O60331-2;O60331-3 O60331-4 PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1 12714130.0 1409900.0 10573100.0 731130.0 True False 1931178.1311148675 10105945.481433889 558452.1520950091 1.0 5.233046770056233 0.2891769242294677 20.881049813376283 -6.680025587674151 1.9015991286003957 3.678289796955613 0.3079329783011316 0.3242139053687383 1.794067814585764 0.4385341523299274 3.065908736032839 0.7569909323328643 1.9965916314198389 2.089173037754818e-07 6.680025587674151 -3.3703568186544812 QAQGAQSTSDEK(ub)RPVGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QAQGAQSTSDEKRPVGQK 18 2 O60331-4;O60331;O60331-2;O60331-3 O60331-4 PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1 6175710.0 2034700.0 3789200.0 351810.0 True False 1691943.2024934615 3768786.82750269 425371.84441434895 1.0 2.2274901556674767 0.2514102387050979 20.690249708197896 -6.738712627326524 1.691411050494246 1.731447792133314 0.25058326519603624 0.5991202000758992 0.5157581684309469 0.32016574405014475 1.7979794764502273 0.24127686507868068 0.5929101845716096 1.825102973549679e-07 6.738712627326524 -1.4808645269372778 QAQGAQSTSDEK(ub)RPVGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QAQGAQSTSDEKRPVGQK 18 2 O60331-4;O60331;O60331-2;O60331-3 O60331-4 PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1 23791280.0 19050700.0 4181600.0 558980.0 True False 24661506.69543872 3948890.2840781775 457251.3756191462 1.0 0.16012364260000977 0.01854109650582368 24.555757608138624 -10.890161357785543 0.3490816979800921 1.9153347819428 2.4326022680846364e-14 0.999196374417438 0.012279530453987319 2.818391076337972 0.18498890686665145 2.154298415175877 0.04266228211939049 1.2877710043192105e-11 10.890161357785543 -1.9153347819427755 QAQGAQSTSDEKRPVGQK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAQGAQSTSDEKRPVGQK 18 2 O60331-4;O60331;O60331-2;O60331-3 O60331-4 PIP5K1C Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1 36611300.0 11277000.0 16048000.0 9286300.0 True False 10919017.807717722 22456050.089214418 6853939.44697156 1.0 2.056599822865217 0.6277065911667526 23.380339752368165 -6.708601478972536 1.800054174270132 1.650482605746563 0.6311758717233752 0.45856806125137306 0.44534145537205305 0.3778681328495793 2.385786297954075 0.19694217756088092 0.5012014992970144 1.956133636579226e-07 6.708601478972536 -1.0193067340231878 QAQIEVVPSASALIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QAQIEVVPSASALIIK 16 0 P30050 P30050 RPL12 60S ribosomal protein L12 0 87449000.0 18213000.0 39500000.0 29736000.0 False True 23877419.374942917 33606753.96979409 26659203.96785341 1.0 1.407470105628801 1.1165027321097232 24.50914358556487 -10.117876855365987 4.611635353421561 0.9999775999765419 1.2619864188746186 0.5194514574264302 0.11878693283822021 82832323.93056715 0.4361453843129239 19702.50282802007 0.040663926654977006 7.622951289286045e-11 10.117876855365987 0.2620088188980767 QAQIEVVPSASALIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAQIEVVPSASALIIK 16 0 P30050 P30050 RPL12 60S ribosomal protein L12 0 95780000.0 42849000.0 18577000.0 34354000.0 False True 41488781.94935677 25994892.97777518 25355656.802091334 1.0 0.6265523294828421 0.6111448832853585 25.30621796660264 QAQIEVVPSASALIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QAQIEVVPSASALIIK 16 0 P30050 P30050 RPL12 60S ribosomal protein L12 0 168294000.0 14586000.0 129680000.0 24028000.0 False True 22128028.379435852 106537590.80553544 19278855.26815349 1.0 4.814599338843201 0.871241438124231 24.39937157608577 -6.653716398124775 1.994973287150935 3.4679747037153303 0.8877203643907713 0.20932445238697817 1.6266332841237237 0.49952574554496404 3.814718248862834 0.6602614677617868 1.8024536004290626 2.2196454138281052e-07 6.653716398124775 -2.580254339324559 QAQIEVVPSASALIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QAQIEVVPSASALIIK 16 0 P30050 P30050 RPL12 60S ribosomal protein L12 0 85851000.0 18213000.0 31247000.0 36391000.0 False True 24946838.28781837 29866404.21998894 27796195.29617097 1.0 1.1972019810852268 1.1142171595245378 24.572353647087763 -10.160333668705967 4.367489839465487 0.9999671755773614 1.1557095703099503 0.8243861779749093 0.033878411562202754 23910711.957939096 13569675.23227984 8661.337557268382 0.012398229300932028 6.912996409136498e-11 10.160333668705967 0.15574239473258888 QAQIEVVPSASALIIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QAQIEVVPSASALIIK 16 0 P30050 P30050 RPL12 60S ribosomal protein L12 0 69788000.0 42849000.0 12887000.0 14052000.0 False True 35630842.03255632 12817575.173130786 16990208.230892897 1.0 0.359732592382162 0.4768399302876071 25.086623242036918 -9.992062649329743 6.079691863734712 1.0000004332721866 0.4182862613367144 0.9705010304154722 0.047808870500855784 2.807591403031221e-07 4.651758588150072e-08 0.046290774300170916 0.015430246604206495 1.0184444613307505e-10 9.992062649329743 -0.5817141719354721 QAQIEVVPSASALIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QAQIEVVPSASALIIK 16 0 P30050 P30050 RPL12 60S ribosomal protein L12 0 61952000.0 14586000.0 32056000.0 15310000.0 False True 18881864.533044413 30272055.420511283 12523737.093865825 1.0 1.6032344352186905 0.6632680301221588 24.17049789817822 -6.733368957667899 1.7107751036307253 1.3616481017017819 0.663454591514327 0.5749062822141724 0.25352509785306365 0.32994873145241077 1.893295226774466 0.11736130880100581 0.29013902694495014 1.847698228101614e-07 6.733368957667899 -0.6981935101874549 QAQIEVVPSASALIIK(ub)ALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAQIEVVPSASALIIKALK 19 1 P30050 P30050 RPL12 60S ribosomal protein L12 1 21707300.0 5573300.0 9698800.0 6435200.0 True False 5396378.642170179 13571581.418573832 4749628.0681381505 1.0 2.514942393500386 0.880151001825933 22.36356014926642 -6.663227346974352 1.9611977340854359 1.9725259108198046 0.8868843183145901 0.2495390082707033 0.6445295002445587 0.47682213928009043 3.5288259367565313 0.2651895614525948 0.7148845361183461 2.171564098397414e-07 6.663227346974352 -1.0856415925052145 QAQIEVVPSASALIIK(ub)ALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QAQIEVVPSASALIIKALK 19 1 P30050 P30050 RPL12 60S ribosomal protein L12 1 22600200.0 10857000.0 6292400.0 5450800.0 True False 16470862.753018972 5169472.057254404 4373446.990829487 1.0 0.3138555723990161 0.26552628459173283 23.973412790429578 -13.87491260549533 0.3776393489766433 9.999999999132378 0.26106079207580335 0.9998009531087435 0.004732287520481941 21.51660476366295 0.19990799341937585 156.66476598961043 0.013198618612589011 1.3337898080621275e-14 13.87491260549533 -9.738939207056575 QAQIEVVPSASALIIK(ub)ALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QAQIEVVPSASALIIKALK 19 1 P30050 P30050 RPL12 60S ribosomal protein L12 1 5279900.0 1626500.0 2322300.0 1331100.0 True False 2227861.0045097778 2219693.1071808576 1016721.5948650262 1.0 0.9963337491376768 0.45636670905721394 21.087227795556984 -6.9083890019871586 0.9066351528679957 1.017582168859605 0.388937126951744 0.9902992941815311 0.025156023372331124 0.10549301844226279 0.14461707941010907 0.02043290560723777 0.05579394856677048 1.2348408784007028e-07 6.9083890019871586 -0.628645041907861 down QAQYLGMSCDGPFKPDHYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QAQYLGMSCDGPFKPDHYR 19 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 11076200.0 1526300.0 4667800.0 4882100.0 False True 2000994.0807102246 3971382.43494189 4376947.124410043 1.0 1.9847047391226185 2.187386342920368 20.93228546883038 -10.706700518196744 0.3157635486615031 6.233223809300477e-16 2.2405695887105543 0.9991719426314551 0.01492352096495507 2.362514398095453 0.15578200684644344 1.8787683804507773 0.06823761666645554 1.9647146423213533e-11 10.706700518196744 2.240569588710554 QAQYLGMSCDGPFKPDHYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QAQYLGMSCDGPFKPDHYR 19 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 7514500.0 1526300.0 3179200.0 2809000.0 False True 2090614.3567065902 3038732.4317914955 2145572.0531709557 1.0 1.4535117019757318 1.0262878212273172 20.99549553035327 -10.48754286601869 3.4825536332097653 0.9960952408772226 1.2398997616253329 0.29598476775876514 0.17441342025263692 59427734.62724332 8721.45209828936 1876736.035825067 0.06293597572805364 3.2542966114101576e-11 10.48754286601869 0.24380452074811032 QASESK(ub)LLEIQTEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QASESKLLEIQTEK 14 1 B3KVZ3;Q9H3R5;H0Y9E6 B3KVZ3 CENPH Centromere protein H 1 12477700.0 1502300.0 3276700.0 7698700.0 True False 1944756.964760222 3094348.764549207 6297615.595332774 1.0 1.5911236317031128 3.238253267348106 20.8911584429711 -6.953097965022408 0.523729160813979 0.9727960088213715 3.930556644345779 0.9994225161395895 0.02275860892519983 0.08226507466678237 0.030994636725584338 0.025632195234137855 0.13610667505336635 1.1140432074007464e-07 6.953097965022408 2.9577606355244077 QASLADCLNHAVGFASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QASLADCLNHAVGFASR 17 0 O43592 O43592 XPOT Exportin-T 0 12170100.0 3753500.0 3749100.0 4667500.0 False True 4920874.848945711 3189748.893877337 4184551.8738214904 1.0 0.6482076849730766 0.8503674655977125 22.230483394651937 -10.191473900440533 5.353193244230433 1.0000117755012572 0.7492875752853403 0.6722057710375622 0.0825313848407472 1.1599347881482261e-05 1.7520982618416613e-06 0.0799144214578078 0.026636889918943307 6.434667339009755e-11 10.191473900440533 -0.2507242002159169 QASLADCLNHAVGFASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QASLADCLNHAVGFASR 17 0 O43592 O43592 XPOT Exportin-T 0 8834500.0 3753500.0 2648100.0 2432900.0 False True 5141270.384523486 2531098.1859043334 1858299.1271483165 1.0 0.49230987608112853 0.36144746106765036 22.29369345617483 -13.99999999999999 0.19034658283985623 3.7247905066623543 0.26789215939385774 0.9994892205665112 0.006224233865381838 12.35638534667638 0.13835605920840136 12.489020851253391 0.08974842818817996 1.0000000000000246e-14 13.99999999999999 -3.4568983472684964 QASPNIVIALAGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QASPNIVIALAGNK 14 0 P51148;P51148-2;K7ENY4;K7ERI8;K7ERQ8 P51148 RAB5C Ras-related protein Rab-5C 0 20040800.0 6958000.0 5312200.0 7770600.0 False True 9122005.381367851 4519640.466793417 6966572.852858536 1.0 0.4954656654802032 0.7637106712399125 23.12091959061285 -10.044302868990084 5.159699881559247 1.0000043408469805 0.6295881683588311 0.7177061011967583 0.1095105650311522 5.468436330146436e-06 1.0130083317075454e-06 0.10603439183971897 0.03534438288266919 9.030195048767511e-11 10.044302868990084 -0.3704161724881494 QASPNIVIALAGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QASPNIVIALAGNK 14 0 P51148;P51148-2;K7ENY4;K7ERI8;K7ERQ8 P51148 RAB5C Ras-related protein Rab-5C 0 17545600.0 6958000.0 3847500.0 6740100.0 False True 9530560.632879814 3677504.7280189293 5148227.196716823 1.0 0.38586447006399366 0.540180939509033 23.18412965213574 -10.371655209966773 8.881377947278951 1.0000014105495958 0.46302270478706287 0.9416724362853951 0.06299943484135627 1.7595687693426328e-06 1.244508610214395e-07 0.06099910041555723 0.020332980163421 4.249568068332594e-11 10.371655209966773 -0.5369787057625329 QASPQNLGTPGLLHPQTSPLLHSLVGQHILSVQQFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QASPQNLGTPGLLHPQTSPLLHSLVGQHILSVQQFTK 37 0 F8VPD4;P27708;H7BZB3 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 167186000.0 108410000.0 24478000.0 34298000.0 False True 90147718.37731181 24346132.155497417 41469553.22396557 1.0 0.2700693106130216 0.4600177793784578 26.42578764197683 -10.91274808088802 11.425349155374432 1.0639529087005914 0.36504354499575303 0.9371026781828617 0.07754613764971781 0.03631407992774279 0.0002773191035173679 0.021583845180289277 0.025027908306672068 1.2225085892118435e-11 10.91274808088802 -0.6989093637048385 QASPSIVIALAGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QASPSIVIALAGNK 14 0 P61020 P61020 RAB5B Ras-related protein Rab-5B 0 4368000.0 1394600.0 1515000.0 1458400.0 False True 1828334.10532561 1288967.905423747 1307498.7579606322 1.0 0.7049958219721517 0.715131197384615 20.802098298392394 -9.936023942281706 5.294289777784814 1.0000006750023902 0.7100635096764809 0.9990843316933249 0.004137749692005779 3.296813107335064e-08 6.61915256732568e-09 0.004006368281636604 0.0013354529696987336 1.1587134755157903e-10 9.936023942281706 -0.2899371653259093 QASQGMVGQLAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QASQGMVGQLAAR 13 0 Q9Y230;X6R2L4 Q9Y230 RUVBL2 RuvB-like 2 0 8523100.0 0.0 4396800.0 4126300.0 False True 0.0 3740814.578592161 3699350.058264513 0.0 QATENAK(ub)EEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QATENAKEEVR 11 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 11816200.0 2338500.0 3585900.0 5891800.0 True False 3065796.1460662107 3050897.6977287196 5282173.054136359 1.0 0.9951404308611296 1.722936817215988 21.5478303404119 -6.905396976161677 0.926525301408412 0.974055803551511 1.8082852591291922 0.9890650225477391 0.03575753301950711 0.10754111398542693 0.15586652643385512 0.028624512910864434 0.07670890550986822 1.2433775563217483e-07 6.905396976161677 0.8342294555776812 QATENAK(ub)EEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QATENAKEEVR 11 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 13383900.0 2338500.0 2945500.0 8099900.0 True False 3203106.6455862923 2815358.0705340463 6186870.442676905 1.0 0.8789460926670853 1.9315218402740595 21.61104040193479 -6.878273257295982 1.0893484625060799 0.9265504414948611 2.0037009670670707 0.9722673000352627 0.07831309461960034 0.12917233112579724 0.281602405336094 0.05546028789238082 0.13355216487146868 1.32350852400799e-07 6.878273257295982 1.0771505255722096 QATENAK(ub)EEVRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QATENAKEEVRR 12 2 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 2673200.0 657620.0 1288700.0 726880.0 True False 862146.1884011396 1096430.9833132569 651669.4303253058 1.0 1.2717460194849335 0.7558688295471497 19.717572992706458 -6.763569834437017 1.598969946745998 1.1571409648174353 0.7536393940855212 0.7054100994205006 0.11436336777210576 0.276952206536992 1.3963021768009796 0.05641102029426287 0.13509449494033354 1.723574918355111e-07 6.763569834437017 -0.40350157073191417 QATENAK(ub)EEVRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QATENAKEEVRR 12 2 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 5574830.0 422620.0 1490510.0 3661700.0 True False 409204.1594304917 2085678.4159069685 2702590.9213546584 1.0 5.096914016733612 6.604505010691922 18.64246128413209 -9.05016285908345 0.385447328194518 1.6209689777530553e-20 6.908252616208466 0.9977553480371611 0.11219185984079165 0.49628535601967605 0.14193993720971465 1.1906028583276769 0.3924278944682563 8.909167844539871e-10 9.05016285908345 6.908252616208466 QATENAK(ub)EEVRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QATENAKEEVRR 12 2 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 5232960.0 657620.0 1058100.0 3517240.0 True False 900759.8855122776 1011349.6433312087 2686540.351831618 1.0 1.1227738486112055 2.9825266367226564 19.78078305422935 -6.920305741975171 0.8224553270835555 0.9594161886640231 3.2845484380815275 0.994265427677022 0.06868585774867782 0.09799228907403366 0.10468438010069592 0.059275834096834235 0.1780817623388519 1.201418342023464e-07 6.920305741975171 2.3251322494175044 up QATENAK(ub)EEVRR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QATENAKEEVRR 12 2 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 1 4722470.0 422620.0 1927330.0 2372520.0 True False 351427.25524047087 1916947.0907449487 2868602.962706943 1.0 5.45474792338813 8.162721928736136 18.422866559566366 -8.354585731145754 0.3349991307035614 1.6076336268668123e-17 9.33627364200447 0.9982364643037638 0.12401015562988592 0.12810985487664042 0.09020261806999341 0.7761685595398425 0.7695795124124475 4.4199185763048445e-09 8.354585731145754 9.33627364200447 QATINIGTIGHVAHGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QATINIGTIGHVAHGK 16 0 P41091;Q2VIR3;Q2VIR3-2;H7BZU1 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 73986000.0 16790000.0 31151000.0 26045000.0 False True 22011852.594591275 26503392.225646973 23350113.241281323 1.0 1.2040509589892199 1.0607972746019063 24.39177723681735 -10.48466808392288 4.865277612874558 0.999588155176133 1.132424116795502 0.5325706792667044 0.05848307175381478 0.00026206753796881733 2.7758179567885193e-05 0.056800908184730506 0.018875330244791884 3.275909655430831e-11 10.48466808392288 0.13283596161936906 QATINIGTIGHVAHGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QATINIGTIGHVAHGK 16 0 P41091;Q2VIR3;Q2VIR3-2;H7BZU1 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 48608400.0 11448000.0 8766400.0 28394000.0 False True 11084589.506318389 12266869.236172078 20956759.598258782 1.0 1.106659766622821 1.8906211715204342 23.40205200833066 -6.931707733921783 0.7326378759744386 0.9888017418883276 2.058795324292671 0.9968634142510103 0.02223953625645325 0.09176054950555478 0.07340648762571778 0.020471197380865266 0.07028057351394337 1.1702866910026542e-07 6.931707733921783 1.0699935824043432 QATINIGTIGHVAHGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QATINIGTIGHVAHGK 16 0 P41091;Q2VIR3;Q2VIR3-2;H7BZU1 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 67703000.0 15039000.0 32462000.0 20202000.0 False True 22815262.498171937 26668902.47323636 16209065.845148843 1.0 1.1689062300016577 0.7104483608920821 24.443495916839385 -6.806967247211637 1.427132270786247 1.0923903702814255 0.7029648703101499 0.8517723622733571 0.07288596986315764 0.2109764836080359 0.8474272638595649 0.040163224416589115 0.09304471069401019 1.5596701226019174e-07 6.806967247211637 -0.3894254999712756 QATINIGTIGHVAHGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QATINIGTIGHVAHGK 16 0 P41091;Q2VIR3;Q2VIR3-2;H7BZU1 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 52397000.0 16790000.0 15624000.0 19983000.0 False True 22997716.732689273 14933680.0183412 15263426.962803561 1.0 0.6493548986588856 0.663693145724676 24.454987298340242 -9.802405560934659 6.301896638038422 1.0000000097449453 0.6565240221989206 0.9986947496009972 0.005853564853471512 8.012655877445888e-10 1.4741701710926996e-10 0.005667689966999201 0.0018892299326963315 1.5761387231265522e-10 9.802405560934659 -0.3434759875460247 QATINIGTIGHVAHGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QATINIGTIGHVAHGK 16 0 P41091;Q2VIR3;Q2VIR3-2;H7BZU1 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 30202600.0 11448000.0 9858700.0 8895900.0 False True 9519519.232390605 9805589.226301277 10755991.56000571 1.0 1.0300508867020621 1.1298881064715904 23.182457283764936 -6.949136942195276 0.5682380884833391 0.9987462883301298 1.166032066100938 0.9991318039675963 0.0016358726518530193 0.08383415273774834 0.037410745642820334 0.0017366101139719 0.00831484752025523 1.1242504182397097e-07 6.949136942195276 0.16728577777080822 QATINIGTIGHVAHGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QATINIGTIGHVAHGK 16 0 P41091;Q2VIR3;Q2VIR3-2;H7BZU1 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 58224000.0 15039000.0 25765000.0 17420000.0 False True 19468281.96300939 24331155.100744788 14249738.744294114 1.0 1.2497844004404228 0.7319463921556744 24.214622238931835 -6.775534561436205 1.5530315093773805 1.1422598595188294 0.7283898875584631 0.751296125588543 0.10545074355768799 0.25760677178934477 1.2268347565761715 0.05349431212407693 0.12671580201043917 1.6767388944715827e-07 6.775534561436205 -0.41386997196036623 QATK(ub)DAGTIAGLNVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QATKDAGTIAGLNVLR 16 1 P11142;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 56560000.0 13131000.0 27849000.0 15580000.0 True False 17214868.160784908 23694037.754551746 13967931.053912956 1.0 1.376370561380554 0.811387628615803 24.037151796353164 -6.727160015506706 1.7338518018104379 1.2272132780972578 0.8119101594385425 0.5459576813523489 0.1582552656854532 0.34157507159583134 2.010418214335402 0.07237470186156571 0.180154952696106 1.8743037948694072e-07 6.727160015506706 -0.4153031186587153 QATK(ub)DAGTIAGLNVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QATKDAGTIAGLNVLR 16 1 P11142;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 90527000.0 20352000.0 25806000.0 44369000.0 True False 19705936.900121585 36110470.37651223 32747427.858531468 1.0 1.8324665586587476 1.661805171939296 24.232127006888348 -10.03461873119061 4.492468468471802 0.999967346751933 1.7471358651484035 0.9623415969856919 0.06967221960437864 48564847.153595775 86969340.37991726 23775.74636317674 0.025497422466836915 9.23381711811381e-11 10.03461873119061 0.7471685183964705 QATK(ub)DAGTIAGLNVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QATKDAGTIAGLNVLR 16 1 P11142;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 206525000.0 26759000.0 34776000.0 144990000.0 True False 40595359.34494199 28569951.093871843 116332662.94862539 1.0 0.7037738193449823 2.865664076529968 25.274811479486615 -6.872289967883015 1.1219840261697243 0.8299254516731221 2.9978687322985555 0.9669120906495853 0.17407466154995468 0.13467439820009328 0.31547605173562226 0.12023807051357999 0.2858403061485195 1.341868728798679e-07 6.872289967883015 2.1679432806254333 up QATK(ub)DAGTIAGLNVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QATKDAGTIAGLNVLR 16 1 P11142;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 57088000.0 13131000.0 14791000.0 29166000.0 True False 17985885.551932305 14137484.71270384 22277591.492625177 1.0 0.7860321734997912 1.2386152145970812 24.100361857876056 -6.77815446987513 1.5431578164439437 0.8785552299395679 1.2419889221966143 0.7607712396992907 0.09041571327263301 0.25345348059368883 1.1920293551476726 0.04615481597301827 0.10907082463696077 1.6666543114572907e-07 6.77815446987513 0.36343369225704636 QATK(ub)DAGTIAGLNVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QATKDAGTIAGLNVLR 16 1 P11142;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 106980000.0 26759000.0 35134000.0 45087000.0 True False 34640052.998747796 33178762.01473184 36881628.63168707 1.0 0.9578149899462111 1.064710513953899 25.045937801579065 -6.799654559433108 1.4574379855269843 0.9767144662750089 1.0661716395394776 0.8311188677247724 0.018066125179752996 0.22125195359960084 0.9278845752762674 0.009752144857854026 0.02268352236228832 1.5861543279820504e-07 6.799654559433108 0.08945717326446867 QATVGDINTERPGMLDFTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QATVGDINTERPGMLDFTGK 20 1 P07108;B8ZWD1;A0A0A0MTI5;P07108-3;P07108-2;P07108-4;P07108-5 P07108 DBI Acyl-CoA-binding protein 0 36819800.0 2843800.0 17584000.0 16392000.0 False True 3728249.3393983776 14960535.741895163 14695913.083166959 1.0 4.012750859712973 3.9417731340732747 21.8300669176974 -10.249096245270627 4.756491706330245 0.9992017304668598 3.9772619969002188 0.999573924806416 0.02897653517780092 0.0002453391220845027 3.873154731785903e-05 0.02806173354221996 0.009352136511075226 5.635127602759174e-11 10.249096245270627 2.978060266433359 QATVGDINTERPGMLDFTGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 QATVGDINTERPGMLDFTGK 20 1 P07108;B8ZWD1;A0A0A0MTI5;P07108-3;P07108-2;P07108-4;P07108-5 P07108 DBI Acyl-CoA-binding protein 0 48214200.0 14214500.0 5571500.0 28428200.0 False True 13763268.47812391 7796229.004988672 20982001.59228076 1.0 0.5664518582472197 1.524492646905108 23.714319783759656 -6.7836577261278315 1.521435727975688 0.7556810915214207 1.5329958824455543 0.7801790888059044 0.18365136233990004 0.2449317144470869 1.120009726758587 0.09504809180438879 0.22361519286381473 1.645668187582422e-07 6.7836577261278315 0.7773147909241336 QATVGDINTERPGMLDFTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QATVGDINTERPGMLDFTGK 20 1 P07108;B8ZWD1;A0A0A0MTI5;P07108-3;P07108-2;P07108-4;P07108-5 P07108 DBI Acyl-CoA-binding protein 0 39080800.0 2843800.0 17479000.0 18758000.0 False True 3895229.7108053514 16706719.98467652 14327746.733136626 1.0 4.289020475052381 3.6782803061374056 21.893276979220293 -10.542838322004236 8.629076885462478 0.999661261614761 3.9836503905948932 0.9695322334606198 0.24933362987714972 0.0016249549748172819 8.608856903234981e-05 0.24143268978021318 0.08047208301363708 2.865244436969286e-11 10.542838322004236 2.983989128980132 QAVDFLSNEGHIYSTVDDDHFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAVDFLSNEGHIYSTVDDDHFK 22 0 P15927;P15927-2;P15927-3;Q5TEJ0 P15927 RPA2 Replication protein A 32 kDa subunit 0 12609900.0 4195500.0 2088700.0 6325700.0 False True 4062316.1490005916 2922728.8024266036 4668809.403067738 1.0 0.7194734962087211 1.149297403703145 21.95387109080134 -6.730581674074243 1.7210124218638196 0.831291318244136 1.1490737110844225 0.5620081109917054 0.11792131210381138 0.33514648930019625 1.9449694765166563 0.05429130550838478 0.13463652822743133 1.8595948121356356e-07 6.730581674074243 0.3177823928402864 QAVEMK(ub)NDKSEEEQSSSSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QAVEMKNDKSEEEQSSSSVK 20 2 B2R5W2;P07910-2;G3V4W0;B4DY08;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 40985600.0 15977100.0 16596800.0 8411700.0 True False 20946132.82245648 14120622.13381969 7541337.974723989 1.0 0.6741398163331077 0.36003485887566195 24.32018057530283 -7.258675049959527 0.25109839302510517 1.114696652988303 5.602715985640147e-11 0.999951810025745 0.0018137660191464519 0.09954260895157481 0.014770266825717108 0.01382016518731397 0.043864369199336645 5.5121997878046084e-08 7.258675049959527 -1.1146966529322757 down QAVEMK(ub)NDKSEEEQSSSSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAVEMKNDKSEEEQSSSSVK 20 2 B2R5W2;P07910-2;G3V4W0;B4DY08;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 18595000.0 6296600.0 5207500.0 7090900.0 True False 6096717.879584586 7286881.906753743 5233580.567559799 1.0 1.1952138922410251 0.8584259056967224 22.539601357381667 -6.749553266510648 1.6514321617321897 1.1148502415513084 0.8577772011361808 0.647050551780551 0.08202865506903803 0.30083691701217075 1.6140885398424054 0.03923985303686274 0.09531095018179107 1.7801095638272378e-07 6.749553266510648 -0.2570730404151276 QAVEMK(ub)NDKSEEEQSSSSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QAVEMKNDKSEEEQSSSSVK 20 2 B2R5W2;P07910-2;G3V4W0;B4DY08;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 70257700.0 31608800.0 13726000.0 24922900.0 True False 47952860.51281442 11276488.058272516 19996877.890904877 1.0 0.23515777656807577 0.4170111579800567 25.51511354253233 -10.749940819892117 10.308010016283584 1.001782349764445 0.32608446731297247 0.9482154595313451 0.07424133207651407 0.003043588457529147 7.383343161285124e-05 0.07194517241088377 0.02396128689438278 1.7785217477667564e-11 10.749940819892117 -0.6756978824514724 QAVEMK(ub)NDKSEEEQSSSSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QAVEMKNDKSEEEQSSSSVK 20 2 B2R5W2;P07910-2;G3V4W0;B4DY08;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 28226400.0 15977100.0 4002000.0 8247300.0 True False 21884265.63489278 3825178.4071557503 6299457.598475187 1.0 0.1747912619492608 0.2878532779473845 24.383390636825723 -10.758468370239147 7.1002147667402955 1.0148189643997882 0.23132226994832267 0.984033272782398 0.04615737474763194 0.010424002875002487 0.00035459821077505065 0.043025799966143745 0.014897228641852773 1.743940364393955e-11 10.758468370239147 -0.7834966944514656 QAVEMK(ub)NDKSEEEQSSSSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QAVEMKNDKSEEEQSSSSVK 20 2 B2R5W2;P07910-2;G3V4W0;B4DY08;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 16562600.0 6296600.0 5934800.0 4331200.0 True False 5235901.886676333 5902828.054434431 5236833.894793853 1.0 1.1273756044694436 1.0001780033579108 22.320006632815943 -6.6458897602545255 2.023845521400791 1.0829224369248105 1.000717082414841 0.1774237799025733 0.05442078874208135 0.5185911748858356 4.066823291459852 0.02184708105027856 0.06024613775567367 2.2600093700478631e-07 6.6458897602545255 -0.08220535450996946 QAVEMK(ub)NDKSEEEQSSSSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QAVEMKNDKSEEEQSSSSVK 20 2 B2R5W2;P07910-2;G3V4W0;B4DY08;P07910-4;P07910-3;G3V2D6;G3V5V7;P07910 B2R5W2;P07910 HNRNPC Heterogeneous nuclear ribonucleoproteins C1/C2 1 92272900.0 31608800.0 32425000.0 28239100.0 True False 40918214.70259793 30620520.24613425 23099873.55763465 1.0 0.7483347078725341 0.5645376692392208 25.28623986462478 -7.291820461900806 0.11757048487135015 1.3664182749341998 3.760515601544049e-10 0.9999979473910087 0.00025566335259804017 0.10733201796391545 0.0066037983249284254 0.027457529582054194 0.04671385402728915 5.107160872651242e-08 7.291820461900806 -1.3664182745581481 QAVLGAGLPISTPCTTINK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QAVLGAGLPISTPCTTINK 19 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;H0YEL7;P24752-2;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 65872000.0 12390000.0 28570000.0 24912000.0 False True 16243409.984930659 24307467.36498776 22334345.21277789 1.0 1.4964510153679733 1.3749788519465995 23.95335119402092 -9.990319858812402 4.621139893878099 0.9999908814118518 1.4357149336879087 0.9449186789267867 0.04959080316887012 17072311.469207287 1.3755731826051785 1708.390977553466 0.016976250945800356 1.022539612275994e-10 9.990319858812402 0.43572405227605693 QAVLGAGLPISTPCTTINK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAVLGAGLPISTPCTTINK 19 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;H0YEL7;P24752-2;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 21772700.0 12127000.0 3242800.0 6402900.0 False True 11742035.022984203 4537666.950978595 4725788.407117383 1.0 0.386446381917311 0.4024675789049331 23.48517912914497 -10.098558984552312 6.113976751822828 1.0000018653292984 0.39445698045849625 0.9994752728059637 0.006540626281418027 1.6629942741852434e-07 2.4526065138767378e-08 0.006332953695164969 0.002110978055136193 7.969682414429348e-11 10.098558984552312 -0.605544884870802 QAVLGAGLPISTPCTTINK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QAVLGAGLPISTPCTTINK 19 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;H0YEL7;P24752-2;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 51690000.0 12390000.0 17294000.0 22006000.0 False True 16970917.82716021 16529893.89638968 16808636.02779637 1.0 0.974012959389579 0.9904376533422297 24.016561255543813 -9.976141950002505 4.538998623144889 1.000000400416334 0.9822253063643553 0.6096070907334461 0.006705353235342716 9220533.765536629 4.633909335992637 38.59147952151042 0.0022954207632368525 1.0564721427846283e-10 9.976141950002505 -0.017775094051978746 QAVLGAGLPISTPCTTINK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QAVLGAGLPISTPCTTINK 19 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;H0YEL7;P24752-2;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 13731200.0 4240300.0 4979400.0 4511500.0 False True 5489151.938809008 4702292.01275562 3690453.291899126 1.0 0.8566518225720466 0.6723175698247935 22.388151842747142 -6.967690031743911 0.30841878487137075 1.0289337398879939 0.494189639472627 0.9999583400136468 0.0008656790164358094 0.07705966648411493 0.011699681248314055 0.0029376171192205193 0.01639063302620083 1.0772337915467255e-07 6.967690031743911 -0.5347441004153668 QAVTNPNNTFYATK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QAVTNPNNTFYATK 14 0 P38646;A0A3B3ITI4;D6RJI2;D6RA73 P38646 HSPA9 Stress-70 protein, mitochondrial 0 17280800.0 4504800.0 1653000.0 11123000.0 False True 4361797.589802846 2313051.520281123 8209552.617152644 1.0 0.5302977666108695 1.88214891868096 22.056491392268658 -6.812851857623508 1.4024008574197386 0.7448629019184737 1.9073986865819406 0.8671668926133654 0.20424041723091255 0.20293868499940368 0.7860647130611741 0.11449377608924455 0.26453600468159943 1.53867941038752e-07 6.812851857623508 1.1625357846634667 QAWNFLSHLPVINVGISVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QAWNFLSHLPVINVGISVK 19 0 Q8N3C0 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 0 33443600.0 9754600.0 13029000.0 10660000.0 False True 14798441.356783545 10703873.153958358 8553046.32755603 1.0 0.7233108471286233 0.5779694037599 23.818941896467525 -13.999999999996763 0.08095234056891934 2.483515258163655 0.15149258571342045 0.9998827154219226 0.001895776390967674 12.249098002628674 0.08033037167170688 3.2400404475987585 0.38685867262789564 1.0000000000074524e-14 13.999999999996763 -2.3320226724502344 QAWNFLSHLPVINVGISVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QAWNFLSHLPVINVGISVK 19 0 Q8N3C0 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 0 17695600.0 9754600.0 2545200.0 5395800.0 False True 12627521.991912441 2403557.382589388 4413819.765583355 1.0 0.1903427595793376 0.3495396617333375 23.590068218559974 -10.093736709912305 7.415868303843502 1.0000001388763373 0.26994121105661856 0.9655652869742751 0.06499186315151342 1.492893436061133e-07 1.8081686545587618e-08 0.06292811309596524 0.020976033635400237 8.058668481650991e-11 10.093736709912305 -0.7300589278197187 QCLAEAEQDEQLPPELQEEAAAAAQPEHK(ub)QQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QCLAEAEQDEQLPPELQEEAAAAAQPEHKQQK 32 1 Q14CZ0 Q14CZ0 C16orf72 UPF0472 protein C16orf72 1 47035000.0 13851000.0 22178000.0 11006000.0 True False 21012979.64373824 18220162.62249511 8830659.275898835 1.0 0.8670908615249444 0.42024783850824915 24.324777415106407 -6.94886621270647 0.5711648033704586 1.0055374487103432 0.260032935590091 0.9991092063958619 0.007401245705846408 0.08394443943234117 0.03787282569420981 0.007830788602670245 0.03724143362670652 1.1249514693500768e-07 6.94886621270647 -0.7455045131202522 down QCLAEAEQDEQLPPELQEEAAAAAQPEHK(ub)QQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QCLAEAEQDEQLPPELQEEAAAAAQPEHKQQK 32 1 Q14CZ0 Q14CZ0 C16orf72 UPF0472 protein C16orf72 1 46258000.0 13851000.0 20462000.0 11945000.0 True False 17930392.544028394 19323271.712456413 9771132.56605012 1.0 1.077682580847451 0.5449480563270955 24.095903737198856 -6.869857879592101 1.1347817972336922 1.0439013795961694 0.5138238791283802 0.9645445028693255 0.0442446413811919 0.13699465832961466 0.32979474428299954 0.030260381403272786 0.07162859626174296 1.349404395287245e-07 6.869857879592101 -0.5300775004677891 QCLNQSQNFAEEMK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QCLNQSQNFAEEMKAK 16 1 P49454 P49454 CENPF Centromere protein F 1 21004400.0 4081300.0 8503700.0 8419400.0 True False 6191630.482996817 6986148.295288639 6755301.899645882 1.0 1.1283212579422646 1.0910376383404976 22.561887943220025 -10.106341046534292 4.488042341635538 0.9999895542252402 1.1096794481435168 0.9202462679091572 0.01522097398119554 10601765.113092564 0.09181832972324572 1172.1741619082377 0.005210544245478023 7.828146658460415e-11 10.106341046534292 0.10968989391827666 QCLYLYLALLPQNHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QCLYLYLALLPQNHK 15 0 Q92797;A0A087WUE9 Q92797 SYMPK Symplekin 0 52243000.0 18200000.0 15718000.0 18325000.0 False True 27610730.598226547 12913000.094705472 14703055.717867171 1.0 0.46768049287094493 0.5325123746928868 24.718725727309305 -10.32363797703522 5.715539458568283 1.0000680945578704 0.5000964337826098 0.9875427558258388 0.02646750492137367 2.296905151850987e-05 2.7180931476501343e-06 0.02563052153551224 0.008542350481343696 4.7463747282577584e-11 10.32363797703522 -0.49997166077526056 QCLYLYLALLPQNHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QCLYLYLALLPQNHK 15 0 Q92797;A0A087WUE9 Q92797 SYMPK Symplekin 0 34919000.0 18200000.0 5515000.0 11204000.0 False True 23560258.775634736 5208085.401925379 9164986.96274806 1.0 0.22105382846267438 0.3890019651323268 24.489852049401755 -10.379053237405216 8.685656335502317 1.0000028095527593 0.3050278968966017 0.9580376798815654 0.06856453968197683 3.7303512259592228e-06 2.6662913765643104e-07 0.06638759894741977 0.02212911002738949 4.177791506120291e-11 10.379053237405216 -0.6949749126561576 QCMMFSATLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QCMMFSATLSK 11 0 O00148;O00148-2;O00148-3;K7EQN7 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 9175600.0 1950300.0 3385900.0 3839400.0 False True 2556862.186732064 2880736.918134832 3442135.718125384 1.0 1.1266688259865556 1.346234355526526 21.285942971641582 -6.962743442194097 0.39487387618712433 0.987226183982071 1.4936281412023331 0.9998588016787971 0.0016996360237260674 0.07873530933796584 0.017614190395611358 0.0028285715556738526 0.018432413844424064 1.089573564671068e-07 6.962743442194097 0.5064019572202622 QCMMFSATLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QCMMFSATLSK 11 0 O00148;O00148-2;O00148-3;K7EQN7 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 46304200.0 9681200.0 17779000.0 18844000.0 False True 14687088.190524751 14606198.542038975 15119475.140381405 1.0 0.9944924652567987 1.0294399369192597 23.8080450649059 -6.866603839351625 1.1519897420362364 0.9969410835612461 1.0313580774661866 0.961170072093981 0.003023166325397916 0.14014833760042544 0.3497547685484084 0.002040677275900124 0.004804609493181272 1.3595530567207755e-07 6.866603839351625 0.03441699390494046 QCMMFSATLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QCMMFSATLSK 11 0 O00148;O00148-2;O00148-3;K7EQN7 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 9806400.0 1950300.0 3199700.0 4656400.0 False True 2671378.6148757525 3058326.6740070614 3556654.2215682524 1.0 1.1448495757870347 1.3313927878896623 21.349153033164473 -6.967667389843723 0.3088647278825923 0.9708734594669247 1.5112888345544329 0.9999580445622968 0.0008786075050231828 0.07706709528757828 0.011725588434000695 0.0029667542227560396 0.016579800002638354 1.0772899544887283e-07 6.967667389843723 0.5404153750875081 QCPLALDAILGLLSLSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QCPLALDAILGLLSLSVK 18 0 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 0 666020000.0 226540000.0 268070000.0 171410000.0 False True 343677742.29243094 220230814.05953008 137530738.36832795 1.0 0.6408061592540913 0.4001735388825524 28.356481180130846 -8.253008827309532 0.164806095150852 1.3522235694994047 3.7128479380333997e-08 0.9998938804900445 0.002538961731163453 0.08717021516722652 0.034644826229761616 0.12257267446338836 0.1263349688155179 5.584588435928979e-09 8.253008827309532 -1.3522235323709253 down QDAFANFANFSK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 QDAFANFANFSK 12 0 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 156903000.0 64205000.0 70813000.0 21885000.0 True False 84173376.76210448 60247976.426912054 19620550.135743592 1.0 0.7157604784846432 0.2330968637648492 26.32686065894171 -7.15173257312347 0.43723613816227114 1.019876629232651 5.232050462903902e-11 0.999637075228227 0.006030665624111764 0.08188344317803295 0.026121351908710577 0.008277134025063958 0.04201996769990649 7.051271336594856e-08 7.15173257312347 -1.0198766291803305 down QDAFANFANFSK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDAFANFANFSK 12 0 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 291489000.0 145590000.0 90998000.0 54901000.0 True False 140968325.14193675 127333975.94830091 40520781.10530406 1.0 0.9032807605544876 0.2874459994080579 27.070795791976707 -6.934590667946336 0.7080937444936525 1.0079620765355815 0.14484578664325487 0.9973661128172392 0.016196223305534673 0.09032316588782549 0.06650910089233983 0.015181579307737827 0.05438473349144582 1.1625438206241227e-07 6.934590667946336 -0.8631162898923266 down QDAFANFANFSK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 QDAFANFANFSK 12 0 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 218645000.0 92592000.0 39927000.0 86126000.0 True False 140468833.38192257 32801714.898925133 69103158.34963316 1.0 0.23351596300184338 0.49194655273990684 27.065674826106143 -10.292838375114979 5.62343011324279 1.0000672432414863 0.36273125787512783 0.890202449148327 0.1055038464641656 8.895407072544799e-05 1.1186193388237845e-05 0.1021643606339911 0.034051220026373306 5.095204563888233e-11 10.292838375114979 -0.6373359853663585 QDAFANFANFSK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QDAFANFANFSK 12 0 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 144760000.0 64205000.0 54638000.0 25917000.0 True False 87943323.57488482 52223912.496295765 19795938.377369735 1.0 0.5938360113468587 0.22509882015674848 26.3900707204646 -7.707246676448219 0.32363323595098664 1.0847951600252836 8.415528756961365e-22 0.9993027453054171 0.008356705609641519 0.1227799256591987 0.047083738247811854 0.03313335994778249 0.07745305215698187 1.9622454175825638e-08 7.707246676448219 -1.0847951600252836 down QDAFANFANFSK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QDAFANFANFSK 12 0 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 299241000.0 145590000.0 111010000.0 42641000.0 True False 121064535.73058581 110411967.09624021 51557035.950292096 1.0 0.9120091728757662 0.42586407025940215 26.851201067410983 -6.937605068833011 0.6814799170242689 1.0057487215349903 0.3035144237993045 0.9978330811958429 0.01175294745424466 0.08887642662564835 0.05971379343724595 0.011242774533820738 0.0423019680905386 1.1545026421583418e-07 6.937605068833011 -0.7022342977356858 down QDAFANFANFSK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QDAFANFANFSK 12 0 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 231041000.0 92592000.0 49924000.0 88525000.0 True False 119862169.26118517 47145685.513276935 72414358.34320518 1.0 0.39333249017498023 0.6041469029766262 26.836801148198592 -10.119184985233671 5.470029286190027 1.0000076204283257 0.4987396965756543 0.8828786063648331 0.08606462363193867 7.998387543645685e-06 1.2879678521567712e-06 0.08333297868207194 0.02777723783526644 7.600024893035116e-11 10.119184985233671 -0.5012679238526714 QDDCMVLK(ub)EFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QDDCMVLKEFLR 12 1 O95466;O95466-2;O95466-3;K7EK60;K7EJE6;A0A0A0MR62;K7EMY8;K7ERL1 O95466 FMNL1 Formin-like protein 1 1 15647100.0 2191900.0 4530400.0 8924800.0 True False 2837457.75880845 4278279.257458341 7300577.976181164 1.0 1.5077860610178542 2.5729292193047266 21.436167484507926 -6.959102674294172 0.44790932893269025 0.9649078013358706 3.157885375519633 0.9997354328538252 0.01066116557435018 0.08002335281518508 0.022328347884775907 0.014193199873799453 0.0881329226641214 1.0987460472499324e-07 6.959102674294172 2.1929775741837623 QDDIDLQK(ub)DDEDTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDDIDLQKDDEDTR 14 1 Q9NYB0 Q9NYB0 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 1 4095500.0 1506800.0 1309700.0 1279000.0 True False 1458967.4587806198 1832670.0399952708 943991.5308224609 1.0 1.2561418206866555 0.6470271321962403 20.47651627466402 -6.792475048332287 1.4864970353593594 1.1426972524301973 0.6401057455291626 0.8092302510641334 0.10906860333422046 0.23167787518327415 1.0112760630709021 0.05774604425629354 0.13495402580370033 1.6125936735658778e-07 6.792475048332287 -0.5025915069010347 QDDIDLQK(ub)DDEDTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QDDIDLQKDDEDTR 14 1 Q9NYB0 Q9NYB0 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 1 4808320.0 1506800.0 2806300.0 495220.0 True False 1252970.9625581894 2791181.904893064 598768.2123614276 1.0 2.227650909957491 0.4778787619618281 20.256921550098298 -6.718060254168566 1.765919461751777 1.7483734992652649 0.4807983292533695 0.5036620054828169 0.5167194142166288 0.3590212711538872 2.1869173700606592 0.2324128798728412 0.5848614034324566 1.9139903589062208e-07 6.718060254168566 -1.2675751700118953 QDDIVQEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 QDDIVQEKR 9 1 Q5SZ59;Q6GQQ9-2;Q6GQQ9 Q5SZ59 OTUD7B OTU domain-containing protein 7B 1 6145100.0 1651200.0 1906700.0 2587200.0 True False 2164739.190243544 1622227.7922583881 2319501.3621748136 1.0 0.749387177711639 1.0714922946047178 21.04576178752885 -6.6990680840950345 1.8343899893633864 0.8442374256491753 1.070511908919217 0.4131059674986769 0.10580479293122222 0.39744258086087275 2.5994706664224734 0.046028266012764205 0.11850026752985064 1.9995483770164393e-07 6.6990680840950345 0.22627448327004174 QDDIVQEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDDIVQEKR 9 1 Q5SZ59;Q6GQQ9-2;Q6GQQ9 Q5SZ59 OTUD7B OTU domain-containing protein 7B 1 6500900.0 1649600.0 2366200.0 2485100.0 True False 1597234.3509453896 3311035.9995699897 1834177.7585980422 1.0 2.072980710445036 1.1483460504793224 20.60714457408474 -6.61004988418221 2.1537225011525716 1.7168558138399184 1.1516682812755152 0.05043172354545011 0.4625960079491243 0.6125610838516877 5.384502541501525 0.1773750797565533 0.5135093390202582 2.4544269776921073e-07 6.61004988418221 -0.5651875325644031 QDDIVQEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 QDDIVQEKR 9 1 Q5SZ59;Q6GQQ9-2;Q6GQQ9 Q5SZ59 OTUD7B OTU domain-containing protein 7B 1 17524300.0 3261300.0 6795300.0 7467700.0 True False 4947630.53296682 5582625.623078764 5991705.8217908135 1.0 1.1283432717703707 1.2110253144140737 22.23830633961458 QDDIVQEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QDDIVQEKR 9 1 Q5SZ59;Q6GQQ9-2;Q6GQQ9 Q5SZ59 OTUD7B OTU domain-containing protein 7B 1 5293400.0 1651200.0 1717400.0 1924800.0 True False 2261693.2620021747 1641519.5893176636 1470201.882500341 1.0 0.7257923153843154 0.6500447727375894 21.10897184905174 -13.999999999999998 0.18050413394597606 2.424943635444347 0.5901866949281335 0.9994975377204018 0.003369777791585326 12.211318080424167 0.13468754463771931 6.103374733056921 0.05631450714300868 1.0000000000000041e-14 13.999999999999998 -1.8347569405162139 QDDIVQEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QDDIVQEKR 9 1 Q5SZ59;Q6GQQ9-2;Q6GQQ9 Q5SZ59 OTUD7B OTU domain-containing protein 7B 1 6454600.0 1649600.0 2841000.0 1964000.0 True False 1371715.48967082 2825694.9691056553 2374663.31949001 1.0 2.059971612468819 1.7311631583746816 20.387549849519015 -10.292738434476393 5.006243791473408 0.9997421456586898 1.8955673854221011 0.9081828183571754 0.13423548927521387 0.00038643508754236346 5.459400220592286e-05 0.1300092055856872 0.04332431786923485 5.096377216580463e-11 10.292738434476393 0.8958252397634113 QDDIVQEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QDDIVQEKR 9 1 Q5SZ59;Q6GQQ9-2;Q6GQQ9 Q5SZ59 OTUD7B OTU domain-containing protein 7B 1 13038100.0 3261300.0 4391100.0 5385700.0 True False 4221817.139833926 4146731.424912882 4405557.861948604 1.0 0.9822148348841092 1.043521714946163 22.00943266170703 -6.829083987346951 1.3318995236717528 0.9904901990379037 1.0451418346170218 0.9040392740996838 0.007977662511397381 0.18195182020805825 0.6315704987094412 0.004703151893488225 0.010824283129092489 1.4822314116396025e-07 6.829083987346951 0.05465163557911812 QDEHGYISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QDEHGYISR 9 0 P04792 P04792 HSPB1 Heat shock protein beta-1 0 40810820.0 888820.0 21699000.0 18223000.0 False True 1165251.6273451236 18461593.78203953 16337458.76735919 1.0 15.843439604630207 14.020541472730654 20.152210097014247 -9.61147025080835 12.363128041052315 0.9999999968004988 14.93199053868043 0.9873229283742713 0.744195046037762 0.0 0.0 0.7205637602771968 0.24018791830285943 2.446412849702644e-10 9.61147025080835 13.931990541879932 QDEHGYISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDEHGYISR 9 0 P04792 P04792 HSPB1 Heat shock protein beta-1 0 30363300.0 10368000.0 3750300.0 16245000.0 False True 10038873.515156278 5247814.347556141 11989947.160446348 1.0 0.522749324377203 1.1943518505681359 23.259094054488617 -6.715795279576759 1.7740008554867819 0.7083693373214812 1.193102899146952 0.49290227287023936 0.2009371286483612 0.36350147412757927 2.233223435924315 0.09000987127418568 0.22712155304506895 1.9239984614962956e-07 6.715795279576759 0.48473356182547067 QDEHGYISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QDEHGYISR 9 0 P04792 P04792 HSPB1 Heat shock protein beta-1 0 32307820.0 888820.0 15791000.0 15628000.0 False True 1217440.7734573488 15093301.406146059 11936988.268763158 1.0 12.397565232913427 9.804984791879367 20.21542015853714 -9.16661749381584 9.760596782896746 0.9998386220170125 11.101275012401018 0.9529206874564742 1.0584165370600387 0.0 0.0 1.024807403485402 0.34160246782846726 6.813692124970854e-10 9.16661749381584 10.101436390384006 QDFCK(ub)DHFPYAAHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QDFCKDHFPYAAHK 14 1 J3KQ25;Q8N6M9;A8MYA3;I3L1X3 J3KQ25 ZFAND2A AN1-type zinc finger protein 2A 1 87869200.0 1926200.0 49033000.0 36910000.0 True False 2922186.2240826315 40282678.053422384 29614722.321772266 1.0 13.785116677862792 10.134440467109274 21.478616689970597 -9.528240025951167 7.35672965654831 0.9999939969013423 11.959778572493098 0.9231773186924748 1.490382322106825 0.0 0.0 1.4430564782371849 0.48101882607906155 2.963193238715381e-10 9.528240025951167 10.959784575591756 QDFCK(ub)DHFPYAAHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QDFCKDHFPYAAHK 14 1 J3KQ25;Q8N6M9;A8MYA3;I3L1X3 J3KQ25 ZFAND2A AN1-type zinc finger protein 2A 1 57078200.0 1926200.0 10480000.0 44672000.0 True False 2493503.871078437 9896778.787339617 36542154.37342742 1.0 3.969024833740993 14.654941906155127 21.249743012063046 -6.947302865762879 0.5877090986945377 0.8756179047817976 18.283937340397056 0.9989722684362475 0.18798440184418513 0.08458719870886702 0.04058644726817417 0.19535347166650185 0.8946058969283154 1.1290082988244556e-07 6.947302865762879 17.408319435615258 QDFSPEVLK(ub)LANEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QDFSPEVLKLANEER 15 1 Q9H2M9 Q9H2M9 RAB3GAP2 Rab3 GTPase-activating protein non-catalytic subunit 1 28538600.0 2136200.0 4972400.0 21430000.0 True False 2765353.0107973004 4695681.568909115 17529959.89036869 1.0 1.6980405577786493 6.339140001990014 21.39903222859746 -6.933702947865238 0.7157430173687426 0.9381913729149399 7.388481933595485 0.9972172979261228 0.12499760933550735 0.09076018756474387 0.06859132720653371 0.11649992192134084 0.4117241735202152 1.1649225498065319e-07 6.933702947865238 6.450290560680545 QDGNEAVGGFFSQIGQLYMVHHLWAYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QDGNEAVGGFFSQIGQLYMVHHLWAYR 27 0 O75323-2;O75323 O75323-2 GBAS Protein NipSnap homolog 2 0 199592000.0 33364000.0 78430000.0 87798000.0 False True 50615627.235122584 64433553.72361311 70444686.81676951 1.0 1.2729972390602355 1.3917576579568174 25.59307954031483 -12.898492971727128 0.1244872444382257 3.4651435965155953e-22 1.5808864984009063 0.9996998839850988 0.002841350727422854 8.080121929742198 0.09861267078025719 2.154072641998843 0.1561994531892776 1.2633015478989222e-13 12.898492971727128 1.5808864984009063 QDGNEAVGGFFSQIGQLYMVHHLWAYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QDGNEAVGGFFSQIGQLYMVHHLWAYR 27 0 O75323-2;O75323 O75323-2 GBAS Protein NipSnap homolog 2 0 113489000.0 33364000.0 30724000.0 49401000.0 False True 43190355.702762514 29014182.391433414 40410524.89706504 1.0 0.6717745644678177 0.9356376959516527 25.364205862407278 -9.918630603821862 6.209394930364869 1.0000000378666685 0.8037061302097078 0.4245913661150298 0.10772167234481496 5.648882733573425e-08 9.761674677662375e-09 0.10430108095888868 0.034767020251408993 1.2060613391548728e-10 9.918630603821862 -0.19629390765696064 QDHPSSMGVYGQESGGFSGPGENR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDHPSSMGVYGQESGGFSGPGENR 24 0 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;Q01844-4 B0QYK0 EWSR1 RNA-binding protein EWS 0 8929800.0 1890200.0 1290600.0 5749000.0 False True 1830196.6356431684 1805943.3103900882 4243164.433696889 1.0 0.9867482407186499 2.3184199725106343 20.803567228777315 -6.904654490234243 0.9313929776534458 0.9514801435067 2.4721915070920857 0.9887425646301988 0.0662766682567288 0.10805924380482601 0.1587357749899664 0.05286645265653554 0.1410535032861927 1.245505098776624e-07 6.904654490234243 1.5207113635853857 up QDIAFAYQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QDIAFAYQR 9 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YM50;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8 P07355 ANXA2 Annexin A2;Annexin 0 98978000.0 26554000.0 20159000.0 52265000.0 False True 34812551.14930179 17151355.779166527 46857119.16128126 1.0 0.4926773595422213 1.3459834919975704 25.053104206385278 -6.745621091226462 1.66585046159043 0.7001339058878864 1.347151694693678 0.6300277831384189 0.21315039169200278 0.3077310381961229 1.678716840309032 0.10113461918304367 0.24668621888590414 1.7963001608072773e-07 6.745621091226462 0.6470177888057915 QDIAFAYQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDIAFAYQR 9 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YM50;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8 P07355 ANXA2 Annexin A2;Annexin 0 53466100.0 13997000.0 4366100.0 35103000.0 False True 13552672.896570453 6109506.498910717 25908471.232572973 1.0 0.4507971634478647 1.9116871948653902 23.692074076258518 -6.804892828574183 1.4360950214366213 0.6988372901741764 1.934316836106788 0.8460162597230841 0.23642344646169036 0.2138515048249792 0.8701775274253348 0.12949057398043004 0.30026257648518867 1.5671377470579813e-07 6.804892828574183 1.2354795459326116 QDIAFAYQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QDIAFAYQR 9 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YM50;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8 P07355 ANXA2 Annexin A2;Annexin 0 66388000.0 26554000.0 12911000.0 26923000.0 False True 36371731.39486785 12340549.329032445 20564341.89659009 1.0 0.3392895761562159 0.5653935380016518 25.11631426790817 -10.133807669650654 5.228210606906669 1.0000162133910706 0.45234155707855583 0.8866526082721854 0.09230655589206688 1.7445102432661213e-05 2.890116991414074e-06 0.0893780812518759 0.029791812809420067 7.348392247997135e-11 10.133807669650654 -0.5476746563125148 QDIAFAYQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QDIAFAYQR 9 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YM50;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8 P07355 ANXA2 Annexin A2;Annexin 0 28347900.0 13997000.0 8214700.0 6136200.0 False True 11639125.67223719 8170445.780609712 7419251.049416803 1.0 0.7019810603212816 0.6374405825958169 23.472479351692794 -13.999999999999995 0.21500082930825787 2.7599681408546366 0.6012194095887482 0.9994934004944516 0.0035542755818425845 12.86843433242728 0.14693049834123884 9.590839460823483 0.036933893499998066 1.0000000000000123e-14 13.999999999999995 -2.1587487312658884 QDIAFAYQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QDIAFAYQR 9 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YM50;H0YKS4;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4;H0YKV8 P07355 ANXA2 Annexin A2;Annexin 0 22246700.0 8538700.0 13708000.0 0.0 False True 11053515.472940225 12945137.749699572 0.0 1.0 1.1711330916747862 0.0 23.39800194321994 -6.9271518129771845 1.2455444077521074 1.0910325497650808 2.640224528443542e-21 0.9627472611361221 0.09968719826163192 0.11841490843981022 0.3671109585473448 0.06600203762984294 0.1280073394999828 1.1826280812718439e-07 6.9271518129771845 -1.0910325497650808 down QDIAMAK(ub)SAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QDIAMAKSAK 10 1 Q9Y5M8;H7C4H2 Q9Y5M8 SRPRB Signal recognition particle receptor subunit beta 1 5821700.0 1012000.0 1788800.0 3020900.0 True False 1326741.800221941 1521918.012687787 2708326.2465189784 1.0 1.1471094167932272 2.041336336931513 20.33945620168727 -6.935560067048359 0.6996513679093308 0.9887899406340117 2.2539327882527815 0.9975225778448155 0.022903504672979868 0.08985173790332643 0.06427912240338682 0.021605750069998778 0.07858647947690439 1.1599517727146243e-07 6.935560067048359 1.2651428476187698 up QDIAMAK(ub)SAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDIAMAKSAK 10 1 Q9Y5M8;H7C4H2 Q9Y5M8 SRPRB Signal recognition particle receptor subunit beta 1 4575910.0 656700.0 708510.0 3210700.0 True False 635853.4179594063 991421.7378308398 2369721.3510646424 1.0 1.5591985665698402 3.7268359092408443 19.27833469661873 -6.945596634380215 0.6052604416608907 0.9758396066042269 4.422163866221314 0.9988088417867624 0.04058780960177987 0.08530359772703114 0.04366205826094782 0.04144383500952939 0.18248169184109622 1.1334526067707277e-07 6.945596634380215 3.4463242596170867 QDIAMAK(ub)SAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QDIAMAKSAK 10 1 Q9Y5M8;H7C4H2 Q9Y5M8 SRPRB Signal recognition particle receptor subunit beta 1 4913040.0 1012000.0 956640.0 2944400.0 True False 1386163.7482716832 914372.4816145613 2248993.361821487 1.0 0.6596424720777992 1.622458648644945 20.40266626321016 -6.81115940491034 1.409670761113433 0.814762248244178 1.6397508000771834 0.8628317031370315 0.1476458219853845 0.20522220862593735 0.803542890809199 0.08235114221661942 0.19039551426936155 1.5446873682172074e-07 6.81115940491034 0.8249885518330055 QDIAMAK(ub)SAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QDIAMAKSAK 10 1 Q9Y5M8;H7C4H2 Q9Y5M8 SRPRB Signal recognition particle receptor subunit beta 1 5045400.0 656700.0 1306600.0 3082100.0 True False 546075.1467427418 1299561.0864602046 3726552.8599797185 1.0 2.379820971915488 6.8242491572965 19.058739972053008 -6.949842472053801 0.5605696976627121 0.9420452937822207 8.474639231175713 0.9991888682231326 0.07077481545321317 0.08354904880298482 0.03622452679181725 0.07581446860450718 0.3694983739207468 1.1224255083386255e-07 6.949842472053801 7.532593937393492 QDIEASSLK(ub)QLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDIEASSLKQLR 12 1 Q96AP4;Q96AP4-2 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 10948500.0 3362000.0 4692100.0 2894400.0 True False 3255275.150265754 6565679.998978258 2136269.809861246 1.0 2.0169354957421186 0.6562486153242209 21.634348060840157 -6.706685809195451 1.8074517427938186 1.6273057460475617 0.6598050087027938 0.44919048236187675 0.4287600992110241 0.3817562357851771 2.4290835569148506 0.18894441214203792 0.4818687183298215 1.964781185832287e-07 6.706685809195451 -0.9675007373447679 QDLGFFQETK(ub)TGELNSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QDLGFFQETKTGELNSR 17 1 X5CMH5;A0A0G2JLV0;A0A087WYD6;Q03519;A0A140T9S0;E7ENX8;Q03519-2 X5CMH5 TAP2 Antigen peptide transporter 2 1 136151400.0 18802000.0 21970000.0 95379400.0 True False 24649604.078827012 18692161.638389263 85510454.63180913 1.0 0.7583148832173355 3.4690396794348133 24.555061138478006 -6.885147173055143 1.0506314581655063 0.8369597587157218 3.681198716352056 0.9776073267083495 0.18329067847647398 0.1231702899535494 0.24553928917961038 0.13369939551502508 0.3280028195642315 1.3027252380899914e-07 6.885147173055143 2.8442389576363345 up QDLGFFQETK(ub)TGELNSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDLGFFQETKTGELNSR 17 1 X5CMH5;A0A0G2JLV0;A0A087WYD6;Q03519;A0A140T9S0;E7ENX8;Q03519-2 X5CMH5 TAP2 Antigen peptide transporter 2 1 188502200.0 17267000.0 27278000.0 143957200.0 True False 16718868.536477957 38170247.65289081 106250490.69657165 1.0 2.283064046446044 6.355124478953208 23.9949738793309 -6.950178773151996 0.5568769195790687 0.9458466569146801 7.885911969272287 0.9992152424928344 0.06395247918683518 0.08341402591854849 0.035665805415227306 0.06881491245670858 0.33827361608970125 1.1215566812311918e-07 6.950178773151996 6.940065312357607 QDLGFFQETK(ub)TGELNSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QDLGFFQETKTGELNSR 17 1 X5CMH5;A0A0G2JLV0;A0A087WYD6;Q03519;A0A140T9S0;E7ENX8;Q03519-2 X5CMH5 TAP2 Antigen peptide transporter 2 1 437912800.0 24842000.0 245771000.0 167299800.0 True False 37687130.19346943 201911244.8324122 134232921.19989264 1.0 5.357564871506193 3.561770835582303 25.167568604788695 -9.233557445879239 11.542106982343338 0.9999602544662639 4.459667853544251 0.8318971302944831 0.7331298455502617 0.0 0.0 0.7098499204436716 0.23661664014789047 5.840399486684202e-10 9.233557445879239 3.459707599077987 QDLGFFQETK(ub)TGELNSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QDLGFFQETKTGELNSR 17 1 X5CMH5;A0A0G2JLV0;A0A087WYD6;Q03519;A0A140T9S0;E7ENX8;Q03519-2 X5CMH5 TAP2 Antigen peptide transporter 2 1 136568900.0 18802000.0 17512000.0 100254900.0 True False 25753607.504944853 16738261.935560117 76576757.43447793 1.0 0.6499385351099362 2.973438087063131 24.618271200000898 -6.868527356157776 1.1419207899393262 0.8036933674457544 3.1057223403762677 0.9631878804755339 0.19624533191637816 0.1382713270789838 0.3379144692117777 0.133494015710963 0.3152551161462201 1.3535448283583531e-07 6.868527356157776 2.3020289729305135 up QDLGFFQETK(ub)TGELNSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QDLGFFQETKTGELNSR 17 1 X5CMH5;A0A0G2JLV0;A0A087WYD6;Q03519;A0A140T9S0;E7ENX8;Q03519-2 X5CMH5 TAP2 Antigen peptide transporter 2 1 174394200.0 17267000.0 43227000.0 113900200.0 True False 14358275.557799494 42994127.57111228 137716205.2049775 1.0 2.9943796104231777 9.591416786131349 23.775379154765176 -6.949236606359444 0.5671621430603904 0.9167397053560918 11.988240737641002 0.9991400097745013 0.10766521206395076 0.08379373018662138 0.037242155021746666 0.11443740242298928 0.5492864494780324 1.1239924489877807e-07 6.949236606359444 11.07150103228491 QDLGFFQETK(ub)TGELNSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QDLGFFQETKTGELNSR 17 1 X5CMH5;A0A0G2JLV0;A0A087WYD6;Q03519;A0A140T9S0;E7ENX8;Q03519-2 X5CMH5 TAP2 Antigen peptide transporter 2 1 312480000.0 24842000.0 182532600.0 105105400.0 True False 32158458.709028453 172374500.35094905 85977295.67247584 1.0 5.360160507398792 2.6735515047659235 24.938694926881144 -9.604991462341793 8.898308737322354 0.9999999997575533 4.016856006082359 0.6270432195898243 1.0968035324696992 0.0 0.0 1.0619754538291497 0.3539918179430498 2.4831819209057216e-10 9.604991462341793 3.016856006324806 QDLLAEK(ub)VLAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QDLLAEKVLAGK 12 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A0A0MR13;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 70513200.0 8073900.0 8605300.0 53834000.0 True False 10584961.087758822 7321422.783196682 48263774.09219195 1.0 0.6916815964173623 4.559655315880897 23.335512629957552 -6.887608741278967 1.0363975589639625 0.780100300547593 4.877191570300572 0.9793240982420676 0.25238628997313395 0.12110588357009798 0.23333899758994722 0.1861046342502051 0.460153695823137 1.2953623162574212e-07 6.887608741278967 4.097091269752979 up QDLLAEK(ub)VLAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDLLAEKVLAGK 12 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A0A0MR13;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 101457000.0 10882000.0 17172000.0 73403000.0 True False 10536556.866505649 24028869.150796983 54176552.257201746 1.0 2.2805238423931113 5.141770024458559 23.328900164663843 -6.957820563479717 0.4651319153760323 0.9207393260070418 6.617895050110742 0.9996806332584877 0.030942145855538738 0.08048903270717292 0.024078887607378974 0.03920910711287373 0.2362470713486576 1.1019945242106146e-07 6.957820563479717 5.6971557241037 QDLLAEK(ub)VLAGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QDLLAEKVLAGK 12 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A0A0MR13;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 206910000.0 25372000.0 134500000.0 47038000.0 True False 38491178.94165958 110497424.14670345 37740918.68251218 1.0 2.870720699778578 0.9805082546241425 25.198024524168755 -6.6485450819256755 2.013535626323324 2.2153078949228986 0.9884438266011916 0.1882018860508562 0.7987316190757062 0.5121460438954428 3.9782570320344823 0.3218808486529716 0.8847430397385642 2.2462335936784742e-07 6.6485450819256755 -1.226864068321707 QDLLAEK(ub)VLAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QDLLAEKVLAGK 12 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A0A0MR13;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 90742900.0 8073900.0 10351000.0 72318000.0 True False 11059039.018943423 9893658.593820387 55237977.83596192 1.0 0.894621908546772 4.994826199757756 23.398722691480444 -6.901004676993684 0.9549290565836199 0.8341960826507957 5.434048783064307 0.9870585803807138 0.21711186611243172 0.11066840037878645 0.17329310674713874 0.17019891142184862 0.4450857304471447 1.2560164373600487e-07 6.901004676993684 4.5998527004135115 up QDLLAEK(ub)VLAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QDLLAEKVLAGK 12 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A0A0MR13;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 77381000.0 10882000.0 19021000.0 47478000.0 True False 9048865.154339146 18918530.097627085 57405430.28653097 1.0 2.0907074837506228 6.343936980760919 23.10930544009812 -6.945459489606808 0.606649277494125 0.9527080856786557 7.702160824443954 0.9987950589096175 0.08002852801473097 0.08536186231612126 0.04391447144786375 0.08160729831045643 0.358226160091256 1.133810593468952e-07 6.945459489606808 6.7494527387652985 QDLLAEK(ub)VLAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QDLLAEKVLAGK 12 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A0A0MR13;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 147273000.0 25372000.0 78774000.0 43127000.0 True False 32844554.15689037 74390157.65208876 35278328.52038871 1.0 2.264916043516537 1.0740997838446154 24.969150846261204 -6.63193914145277 2.0731965633909386 1.832163623058026 1.0789092844801924 0.1245524887118803 0.5423156592328817 0.5540092461964397 4.54025869612805 0.21374907343218644 0.6007823717783862 2.3337850773000891e-07 6.63193914145277 -0.7532543385778336 QDLMNIAGTTLSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QDLMNIAGTTLSSK 14 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 28467200.0 11639000.0 9382900.0 7445300.0 False True 9678344.19512528 9332352.455340171 9002077.806822293 1.0 0.9642509366468517 0.9301258175294485 23.206328816636674 -6.971692418981421 0.21399880563659215 1.0169797351570056 0.8764401284157367 0.9999926950511594 7.688965606191694e-05 0.07575764107261385 0.0070332726095873365 0.0009901799969374056 0.0035041830334331474 1.0673517857283476e-07 6.971692418981421 -0.14053960674126886 QDLPALEEK(ub)PR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QDLPALEEKPR 11 1 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 1 8502100.0 2549600.0 3223800.0 2728700.0 True False 3342550.290361522 2742821.6062739757 2446360.2995386613 1.0 0.820577513577909 0.7318843658367422 21.67251783588345 -13.999999999999003 0.0920033307628814 1.9110437303474639 0.5171685042574046 0.9998329325907804 0.0014415286586157 12.146013463900195 0.08861533531590719 2.1498252041569796 0.19258126573310635 1.0000000000022946e-14 13.999999999999003 -1.3938752260900593 QDLPALEEK(ub)PR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QDLPALEEKPR 11 1 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 1 8640500.0 2367900.0 4387300.0 1885300.0 True False 1969013.7657562622 4363664.744089133 2279507.5133577 1.0 2.2161677180622092 1.1576899831790575 20.909041766759106 -6.612528529643761 2.1440136752266588 1.8111326069860791 1.1615245171397637 0.05837972662881319 0.5239909823634271 0.6057492575021527 5.2800583493294475 0.2015447971898724 0.5816246192823873 2.440458744325114e-07 6.612528529643761 -0.6496080898463155 QDLPALEEK(ub)PR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QDLPALEEKPR 11 1 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 1 27273900.0 5553500.0 8586400.0 13134000.0 True False 7189115.225850953 8108559.29194779 10743746.766220363 1.0 1.127893911449723 1.4944463162292214 22.77738279648086 -6.952472707443278 0.5310040359105078 0.9942602661806346 1.6447486116383878 0.9993813177138728 0.005212161492665754 0.08250776528752343 0.03196874552657216 0.005806368842956157 0.030315909686744948 1.1156482603159861e-07 6.952472707443278 0.6504883454577532 QDLPNAMAISEMTDK(ub)LGLQSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDLPNAMAISEMTDKLGLQSLR 22 1 P18085;C9JAK5;U3KQF2 P18085 ARF4 ADP-ribosylation factor 4 1 23736900.0 9108600.0 9757500.0 4870800.0 True False 8819452.478795553 13653720.63469029 3594991.35913217 1.0 1.5481369923493187 0.40762069615722085 23.072257663809346 -6.776016657699492 1.5512700142834788 1.3119832359267665 0.39967403558546655 0.7530446974152963 0.23144294123923578 0.25683482485891934 1.2204486661198388 0.11754104015024831 0.2782990688808061 1.6748786335338718e-07 6.776016657699492 -0.9123092003412999 down QDLPNAMNAAEITDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QDLPNAMNAAEITDK 15 0 H0YGG7;P84077;P61204;P61204-2 H0YGG7;P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 0 33179900.0 3241900.0 17312000.0 12626000.0 False True 4250162.294604257 14729117.081647469 11319582.637144092 1.0 3.465542268902683 2.6633295042673395 22.019086501668692 -10.038177653360266 5.6544307396670295 0.9999924795558628 3.064435886585724 0.8982709571671398 0.32750198975318595 3.1049073466939e-05 5.283095674778032e-06 0.3171035973140468 0.10570081267995714 9.158457758009621e-11 10.038177653360266 2.064443407029861 QDLPNAMNAAEITDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDLPNAMNAAEITDK 15 0 H0YGG7;P84077;P61204;P61204-2 H0YGG7;P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 0 28807400.0 8591400.0 3367000.0 16849000.0 False True 8318670.709694604 4711460.658673047 12435741.440834738 1.0 0.5663718186587547 1.494919305597959 22.987921579211147 -6.779706039258619 1.5368845343703657 0.7543751354273783 1.5022238027090873 0.7663865567913433 0.1833549123160994 0.2510345423002847 1.1711463640106348 0.09396489540561334 0.2217844172147986 1.6607106116563868e-07 6.779706039258619 0.747848667281709 QDLPNAMNAAEITDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QDLPNAMNAAEITDK 15 0 H0YGG7;P84077;P61204;P61204-2 H0YGG7;P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 0 39732900.0 3241900.0 14370000.0 22121000.0 False True 4440518.039053327 13735085.884764642 16896475.396295734 1.0 3.0931269198701017 3.8050685185140893 22.082296563191584 -9.506360678711046 0.31944795414951555 1.9208167799246994e-21 4.038694503990721 0.9986003829866917 0.04453980105254599 0.8768708949815724 0.12920760101853374 1.174361130717741 0.23164308320445437 3.1163004420875127e-10 9.506360678711046 4.038694503990721 QDLPNAMNAAEITDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QDLPNAMNAAEITDK 15 0 H0YGG7;P84077;P61204;P61204-2 H0YGG7;P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 0 13356500.0 8591400.0 2551800.0 2213300.0 False True 7144129.763553518 2538052.946907357 2676090.796857047 1.0 0.3552641162616452 0.3745859727393794 22.768326854645423 -10.309201797524906 8.82076383408169 1.0000005122207634 0.3649250445447559 0.9993062422828097 0.007888114875623086 7.945223833762874e-08 6.231901970829865e-09 0.0076376405314548396 0.002545878128854932 4.906798258624944e-11 10.309201797524906 -0.6350754676760075 QDLPNAMNAAEITDK(ub)LGLHSLR ddPTM_RPMI8226_Bortezomib_1h_R1 2 QDLPNAMNAAEITDKLGLHSLR 22 1 H0YGG7;P84077;P61204;P61204-2 H0YGG7;P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 1 233728400.0 141275000.0 80914300.0 11539100.0 True False 185212893.10904625 68842201.84147106 10345144.622863097 1.0 0.37169227630896845 0.05585542371919147 27.46460929061845 -8.674725987497357 0.3988452656014557 1.1170503001074783 9.129410492403348e-20 0.9969397604363969 0.021708383305415847 0.27658721412663156 0.13367350921866483 0.12444298803564352 0.07586974442159584 2.1148229392495878e-09 8.674725987497357 -1.1170503001074783 QDLPNAMNAAEITDK(ub)LGLHSLR ddPTM_RPMI8226_Bortezomib_2h_R1 2 QDLPNAMNAAEITDKLGLHSLR 22 1 H0YGG7;P84077;P61204;P61204-2 H0YGG7;P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 1 863756000.0 276396000.0 434200000.0 153160000.0 True False 267621960.27152133 607578324.3230877 113042801.2984895 1.0 2.2702857557229486 0.42239732936639285 27.99562126325062 -6.721708201495701 1.7531033367979727 1.7714100355268942 0.4249849217821253 0.5205922727706036 0.5344318489979819 0.3520112086846554 2.1152001773996454 0.241965369892225 0.606221599624629 1.897980728851189e-07 6.721708201495701 -1.346425113744769 QDLPNAMNAAEITDK(ub)LGLHSLR ddPTM_RPMI8226_Bortezomib_8h_R1 2 QDLPNAMNAAEITDKLGLHSLR 22 1 H0YGG7;P84077;P61204;P61204-2 H0YGG7;P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 1 1199159000.0 572585000.0 407240000.0 219334000.0 True False 868653306.5706336 334564840.2193573 175982538.76249272 1.0 0.3851534757177057 0.20259237768547292 29.694205248346307 -13.99999999999998 0.17019240380557862 4.102253038252427 0.041882015046917166 0.9995133123074941 0.007525295088446736 12.093420706730456 0.13064358053513525 12.386082291665998 0.14857972369336298 1.000000000000045e-14 13.99999999999998 -4.06037102320551 QDLPNAMNAAEITDK(ub)LGLHSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QDLPNAMNAAEITDKLGLHSLR 22 1 H0YGG7;P84077;P61204;P61204-2 H0YGG7;P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 1 294425500.0 141275000.0 61297500.0 91853000.0 True False 193508185.3133223 58589173.76627432 70159213.17191584 1.0 0.30277361999653185 0.36256457605819764 27.527819352141343 -10.416313190103748 5.296515780570725 1.0005405487116548 0.33266909802735234 0.9940152932151324 0.024409555597418406 0.00015592625926661962 1.7183384771602683e-05 0.023652555275422604 0.00787815019308753 3.834306359654689e-11 10.416313190103748 -0.6678714506843024 QDLPNAMNAAEITDK(ub)LGLHSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 QDLPNAMNAAEITDKLGLHSLR 22 1 H0YGG7;P84077;P61204;P61204-2 H0YGG7;P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 1 813060000.0 276396000.0 426118000.0 110546000.0 True False 229835520.4189232 423822417.75619966 133660657.49304612 1.0 1.8440248791122227 0.5815491759038015 27.776026538684896 -6.726541940088551 1.7357330984781885 1.5098934385017073 0.5827608971583733 0.5431061959765671 0.3549180745240611 0.34281364395304376 2.0217183769612928 0.16214356097506566 0.4039492741303396 1.8769731491567244e-07 6.726541940088551 -0.927132541343334 QDLPNAMNAAEITDK(ub)LGLHSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 QDLPNAMNAAEITDKLGLHSLR 22 1 H0YGG7;P84077;P61204;P61204-2 H0YGG7;P84077 ARF1;ARF3 ADP-ribosylation factor 1;ADP-ribosylation factor 3 1 1216234000.0 572585000.0 497927000.0 145722000.0 True False 741222569.8377362 470216924.7369895 119202091.23398551 1.0 0.6343802035600811 0.1608182158566495 29.465331570438757 -7.487071094817039 0.44553830012461115 1.0247232915713878 5.2008981014271615e-23 0.9983172014108586 0.0140925875944544 0.11672429563393906 0.05611718632853533 0.019315288736990815 0.06657931918074128 3.257833652917718e-08 7.487071094817039 -1.0247232915713878 down QDLPSLDEK(ub)PR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QDLPSLDEKPR 11 1 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 14264300.0 4459300.0 6044700.0 3760300.0 True False 5846185.483922626 5142854.322056052 3371220.2273446023 1.0 0.8796940049540375 0.5766529708329761 22.479064172072352 -6.9553001008079285 0.49726992618922744 1.0062152562519446 0.43712190545622925 0.9995542259015181 0.0037606386363165604 0.08142478788603107 0.02767587418789236 0.004433235263654695 0.024996137180432844 1.1084086317333185e-07 6.9553001008079285 -0.5690933507957154 QDLPSLDEK(ub)PR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDLPSLDEKPR 11 1 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 14478400.0 5570700.0 4139500.0 4768200.0 True False 5393861.177747007 5792423.937207328 3519265.37706619 1.0 1.0738919201526056 0.6524575366502428 22.362886960613444 -6.861634630701798 1.1773348165257862 1.0402827122969096 0.6313921286218893 0.9556034963610953 0.03871548365405265 0.14513377072989753 0.3813238585122528 0.025628905623036234 0.05994450829896128 1.3751984345366816e-07 6.861634630701798 -0.4088905836750203 QDLPSLDEK(ub)PR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QDLPSLDEKPR 11 1 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 10236700.0 4459300.0 2782000.0 2995400.0 True False 6108023.718051298 2659082.0411562463 2287948.2121994565 1.0 0.43534245508866476 0.37458076749731467 22.542274233595244 -13.999999999999998 0.314852573469045 6.615942767407809 0.36181259043959213 0.9996826077727162 0.005016815900849211 17.62257427651111 0.1787258185108501 65.01016627206747 0.020646137863896023 1.0000000000000041e-14 13.999999999999998 -6.254130176968217 QDLPSLDEK(ub)PR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QDLPSLDEKPR 11 1 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 14369400.0 5570700.0 5934300.0 2864400.0 True False 4632283.873853795 5902330.748033683 3463332.796510786 1.0 1.2741729368850794 0.7476512430637139 22.14329223604772 -6.765173206227178 1.592962611337544 1.158215932024263 0.7452133962735319 0.7118445588732256 0.11541928500870786 0.27425527622733603 1.3726486128107762 0.057139080457213054 0.13662406921381054 1.7172233839732925e-07 6.765173206227178 -0.4130025357507312 QDLPSLDEK(ub)PR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QDLPSLDEKPR 11 1 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 56311100.0 8329100.0 15606000.0 32376000.0 True False 10782184.141106548 14737512.381223459 26483900.205813173 1.0 1.3668392403944778 2.456264877247329 23.362146117846322 -6.951678553056595 0.5401059553186514 0.9839720014636448 2.8894505795337087 0.9993264851149459 0.016049656375568246 0.08281872617870448 0.03322704391490852 0.017650228299338846 0.09022131451587627 1.1176902101022681e-07 6.951678553056595 1.9054785780700638 up QDLSK(ub)QACEGNLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QDLSKQACEGNLPK 14 1 Q9H1A4;H0Y564 Q9H1A4 ANAPC1 Anaphase-promoting complex subunit 1 1 3735500.0 1088600.0 961000.0 1685900.0 True False 1427165.1420173966 817622.5459486613 1511459.2402947291 1.0 0.5728997450098139 1.0590640114417151 20.44472085283069 -6.674666776202855 1.9206271981274294 0.7284881986142379 1.0571531557228377 0.29996118566916874 0.1812296287576505 0.45049465552642426 3.207998538170471 0.07584236649416025 0.20142166735010342 2.1151112918438881e-07 6.674666776202855 0.3286649571085999 QDLSK(ub)QACEGNLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QDLSKQACEGNLPK 14 1 Q9H1A4;H0Y564 Q9H1A4 ANAPC1 Anaphase-promoting complex subunit 1 1 18977000.0 2610700.0 4375300.0 11991000.0 True False 3960622.767735719 3594493.5306250737 9620973.594158 1.0 0.9075576598475292 2.4291567660856255 21.917295866619735 -6.892448716814027 1.0077585263004907 0.9229774620776916 2.5664969495473366 0.9824207688899135 0.09234967961719089 0.11717983303620463 0.21040976469409772 0.06958838000491029 0.1750908691761216 1.2810063518309413e-07 6.892448716814027 1.643519487469645 up QDLSK(ub)QACEGNLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QDLSKQACEGNLPK 14 1 Q9H1A4;H0Y564 Q9H1A4 ANAPC1 Anaphase-promoting complex subunit 1 1 14082700.0 2610700.0 2620000.0 8852000.0 True False 3379602.6145906392 2474194.696834904 7241026.8291900875 1.0 0.7320963376442989 2.1425675308477565 21.688422188712185 -6.857546526795064 1.1981301714106212 0.8554960146656246 2.2077159342698063 0.9505787318870208 0.13596760283787848 0.14935365712540286 0.4088136918559426 0.08859673752620796 0.20626521467848163 1.3882045809614538e-07 6.857546526795064 1.3522199196041815 up QDLTTLDVTK(ub)LTPLSHEVISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDLTTLDVTKLTPLSHEVISR 21 1 P41091;Q2VIR3;Q2VIR3-2;H7BZU1 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 58597600.0 15846000.0 13914000.0 28837600.0 True False 15342977.403661875 19469932.760551453 21284167.450543996 1.0 1.2689800843938286 1.3872253664053595 23.87107513849224 -12.93371368765484 0.12226983844943419 4.031794627857097e-22 1.580744803737551 0.9997102422501734 0.0027580673619272077 8.203001063314685 0.09770714290381036 2.150132067410177 0.16005547455493516 1.164893742467465e-13 12.93371368765484 1.580744803737551 QDLTTLDVTK(ub)LTPLSHEVISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QDLTTLDVTKLTPLSHEVISR 21 1 P41091;Q2VIR3;Q2VIR3-2;H7BZU1 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 223444600.0 24115600.0 30826000.0 168503000.0 True False 36585128.28651608 25324859.455362692 135198308.19251132 1.0 0.6922173200277255 3.6954444203039847 25.124753981915937 -6.881632971409631 1.0706825554673094 0.804807683762654 3.915032052225141 0.9749775730055246 0.21339984343935506 0.12619193810902357 0.2636462194598144 0.15330564571270974 0.37230891830543156 1.3133093269914943e-07 6.881632971409631 3.1102243684624873 up QDLTTLDVTK(ub)LTPLSHEVISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QDLTTLDVTKLTPLSHEVISR 21 1 P41091;Q2VIR3;Q2VIR3-2;H7BZU1 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 56922600.0 15846000.0 13231000.0 27845600.0 True False 13176651.096825777 13159721.976852115 33667986.216492385 1.0 0.9987152183169106 2.555124664764245 23.651480413926517 -6.906709402588558 0.9178589466950986 0.9466534072728175 2.742721078387802 0.9896192448197927 0.0747227588303313 0.10663422088790038 0.15087102363343477 0.06019813002084485 0.1626175689940825 1.2396257740121035e-07 6.906709402588558 1.7960676711149843 up QDLTTLDVTK(ub)LTPLSHEVISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QDLTTLDVTKLTPLSHEVISR 21 1 P41091;Q2VIR3;Q2VIR3-2;H7BZU1 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 240547900.0 24115600.0 31591300.0 184841000.0 True False 31218119.589543812 29833216.384015422 151201834.62882125 1.0 0.9556378403396133 4.843399814493143 24.895880304008386 -6.904319028755835 0.9335517159773942 0.8569520080296 5.2892654257347855 0.9885954729608961 0.1946115433474778 0.10829581702487448 0.16002960966029242 0.15498480449697058 0.4127277473142167 1.2464675341941559e-07 6.904319028755835 4.432313417705186 up QDPAHPHVVATGGK(ub)ENALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDPAHPHVVATGGKENALK 19 1 Q6RFH5;Q6RFH5-2;E9PS41 Q6RFH5 WDR74 WD repeat-containing protein 74 1 12147400.0 1381500.0 2278500.0 8487400.0 True False 1337645.038694868 3188316.932220532 6264295.323457823 1.0 2.383529890210151 4.683077454965075 20.351263898416484 -6.96349600340941 0.38298797491729764 0.8472549790724528 6.301057455131941 0.9998787077078 0.016729524548426303 0.07847509356568884 0.016682793720386096 0.029840817630423257 0.19403637639815308 1.087687147014946e-07 6.96349600340941 5.453802476059488 QDPAHPHVVATGGK(ub)ENALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QDPAHPHVVATGGKENALK 19 1 Q6RFH5;Q6RFH5-2;E9PS41 Q6RFH5 WDR74 WD repeat-containing protein 74 1 60282100.0 3730500.0 7252600.0 49299000.0 True False 5659441.236081542 5958316.865177564 39555031.041480705 1.0 1.0528100949596495 6.989211371133104 22.432228190273946 -6.908848658852551 0.903547632278877 0.8094378495480581 7.7377738276257935 0.9904795963020794 0.27427416578690034 0.105184077988263 0.1429365682903406 0.22328141395382092 0.6115439661476527 1.233534615388566e-07 6.908848658852551 6.928335978077735 up QDPAHPHVVATGGK(ub)ENALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QDPAHPHVVATGGKENALK 19 1 Q6RFH5;Q6RFH5-2;E9PS41 Q6RFH5 WDR74 WD repeat-containing protein 74 1 10625400.0 1381500.0 2460000.0 6783900.0 True False 1148778.4608270107 2446747.491728233 8202382.124790366 1.0 2.129868878257701 7.1400904565058045 20.13166917385076 -6.942514417198252 0.6357404691899226 0.9452794469827986 8.597373392934593 0.9984750516234995 0.10419966660927404 0.08663801748645193 0.04952474325306274 0.10347895950138714 0.42667220840159903 1.141525408969719e-07 6.942514417198252 7.652093945951794 QDPSVLHTEEMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDPSVLHTEEMR 12 0 P50502;Q8NFI4;Q3KNR6;F8WAQ7 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 0 8190360.0 2798900.0 470660.0 4920800.0 False True 2710050.451540403 658596.9924594755 3631894.859164321 1.0 0.24302019620525014 1.3401576554045103 21.369888279024956 -6.7211112818771355 1.7557655081797425 0.5399993640987721 1.338502928832968 0.5175729117434745 0.3184969062520187 0.3531534793607792 2.1283024596253775 0.14401553215227367 0.36099988701705304 1.9005912176495983e-07 6.7211112818771355 0.7985035647341958 QDQIQQVVNHGLVPFLVSVLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QDQIQQVVNHGLVPFLVSVLSK 22 0 P52292 P52292 KPNA2 Importin subunit alpha-1 0 2778460000.0 1221300000.0 769890000.0 787270000.0 False True 1852801388.9897852 632497114.3219743 631665739.4273014 1.0 0.34137340250313325 0.3409246901372999 30.787061093971776 QDQIQQVVNHGLVPFLVSVLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QDQIQQVVNHGLVPFLVSVLSK 22 0 P52292 P52292 KPNA2 Importin subunit alpha-1 0 147578000.0 82305000.0 0.0 65273000.0 False True 68440254.22972643 0.0 78921282.51174714 1.0 0.0 1.1531412821296674 26.02834178311666 -10.687573608754262 4.498607801110682 1.016645508212504 0.5765706410690498 0.15238263405284624 0.47076795709288977 0.07931959407311519 0.005508708376241596 0.46003319378568996 0.15193970481238353 2.053177003131506e-11 10.687573608754262 -0.44007486714345434 QDQIQQVVNHGLVPFLVSVLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QDQIQQVVNHGLVPFLVSVLSK 22 0 P52292 P52292 KPNA2 Importin subunit alpha-1 0 2293270000.0 1221300000.0 568810000.0 503160000.0 False True 1580996925.4221268 537155223.475825 411590042.8575788 1.0 0.3397572853169239 0.2603357642505751 30.558187416064225 -13.999999999999998 0.29876702729653803 6.980045791778789 0.2405433427280134 0.9996470788385261 0.006228569369925029 16.50854509548424 0.1735551532375847 60.984881196601606 0.028855414322861626 1.0000000000000041e-14 13.999999999999998 -6.739502449050775 QDQK(ub)APDKEAILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QDQKAPDKEAILR 13 2 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 1917430.0 537170.0 511420.0 868840.0 True False 704235.0719616797 435118.12949954683 778940.7713017811 1.0 0.6178592160817906 1.1060806289184166 19.4256975518015 -6.6979291240887004 1.8382300238162432 0.7622166851055148 1.1045711288144702 0.40764397797206053 0.16137003558060517 0.39991152455835344 2.6257177710781954 0.07007145184681511 0.18066903683510585 2.0047991795184178e-07 6.6979291240887004 0.3423544437089554 QDQK(ub)APDKEAILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QDQKAPDKEAILR 13 2 Q9BSL1 Q9BSL1 UBAC1 Ubiquitin-associated domain-containing protein 1 1 7661600.0 1633600.0 3889100.0 2138900.0 True False 2114727.4030701597 3672668.1662063464 1749642.1469673184 1.0 1.7367099706914326 0.8273606065856002 21.012040275418773 -6.691199996816416 1.8621174054612364 1.4613631106089466 0.8304634857907314 0.37596706156292803 0.3115036138901198 0.41415084790769074 2.7851862831854577 0.13377740259563203 0.3478440493885204 2.036104216057576e-07 6.691199996816416 -0.6308996248182153 QDSLVINLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QDSLVINLNR 10 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 25574600.0 7865900.0 8688400.0 9020300.0 False True 10312271.07348396 7392124.587117944 8086965.8848274145 1.0 0.7168279939930383 0.7842080398392073 23.297858756921233 -9.965866555688091 5.431743452427756 1.000000602409237 0.7505180169155148 0.9481303224766398 0.02750778853021257 2.0067478897471217e-07 3.821430492880819e-08 0.026634366009645263 0.008878100572066268 1.0817662911936052e-10 9.965866555688091 -0.24948258549372215 QDSLVINLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDSLVINLNR 10 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 18631400.0 3886200.0 3869200.0 10876000.0 False True 3762834.70819833 5414191.737611439 8027249.32699382 1.0 1.4388598377215962 2.1332984171492666 21.843388486181446 -6.964353932842609 0.3689786138622002 0.945974946670795 2.6503166833297866 0.9998991934537778 0.004684498218239777 0.07818095646772064 0.01563759889929212 0.009167679150489464 0.05901072870719894 1.0855405903439702e-07 6.964353932842609 1.7043417366589917 QDSLVINLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QDSLVINLNR 10 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 23390500.0 7865900.0 7429100.0 8095500.0 False True 10774135.797954781 7100857.797251564 6183509.6320560565 1.0 0.6590651844762804 0.5739216349240607 23.361068818444124 -13.999999999999998 0.19483154896094274 2.859160475980643 0.5157218086079981 0.9994874693209616 0.004167817045051495 12.433387374238945 0.13997445552194673 8.790704871251043 0.05638095774999128 1.0000000000000041e-14 13.999999999999998 -2.343438667372645 QDSLVINLNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QDSLVINLNR 10 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 11146600.0 3886200.0 3486300.0 3774100.0 False True 3231547.487850833 3467518.6099236337 4563246.860533219 1.0 1.0730210906570137 1.412093394167648 21.623793761615723 -6.941468287686044 0.6457627247699723 0.9962695205145505 1.5076191080555277 0.9983499246070472 0.007293259009896784 0.08710319545674337 0.051607535476158435 0.007181049553404037 0.028999710861008585 1.1442784323224238e-07 6.941468287686044 0.5113495875409771 QDSNPLYK(ub)SAITTTINPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QDSNPLYKSAITTTINPR 18 1 P26010;P26010-2 P26010 ITGB7 Integrin beta-7 1 46734500.0 4027400.0 7473100.0 35234000.0 True False 5279960.401397077 6358142.609915638 31588323.668393437 1.0 1.2042027073220614 5.982681926939295 22.332095679036257 -6.91586905611733 0.8547919412503072 0.8780691377057106 6.684539630856041 0.9929546001844468 0.19324264071905117 0.1006639831635059 0.11865615274164014 0.16295349358778163 0.47041397891892256 1.2137547538072671e-07 6.91586905611733 5.80647049315033 up QDSNPLYK(ub)SAITTTINPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDSNPLYKSAITTTINPR 18 1 P26010;P26010-2 P26010 ITGB7 Integrin beta-7 1 111687700.0 4729700.0 6888000.0 100070000.0 True False 4579558.262406889 9638414.320445474 73858664.96435006 1.0 2.1046602681237183 16.127901586196216 22.12677701407213 -6.922598430411353 0.8052244583955964 0.7185979432294456 18.530159137716723 0.9948727190986548 0.4930560964672477 0.09666691047923091 0.09786922079415561 0.4307716376397116 1.3242316612526972 1.1950926339264052e-07 6.922598430411353 17.811561194487275 up QDSNPLYK(ub)SAITTTINPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QDSNPLYKSAITTTINPR 18 1 P26010;P26010-2 P26010 ITGB7 Integrin beta-7 1 598629300.0 4979300.0 121210000.0 472440000.0 True False 7553962.135590626 99579128.48194759 379062026.9221916 1.0 13.182370614856376 50.18055692074947 22.848802121578228 -6.951174392153225 0.5457967724833946 0.47510901937634376 64.6134612365478 0.9992902623770265 0.55712850104236 0.08301753812074623 0.03403680026954286 0.6080137193814252 3.066959224796402 1.1189884603211635e-07 6.951174392153225 64.13835221717146 QDSNPLYK(ub)SAITTTINPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QDSNPLYKSAITTTINPR 18 1 P26010;P26010-2 P26010 ITGB7 Integrin beta-7 1 56392200.0 4027400.0 5840800.0 46524000.0 True False 5516438.616392663 5582734.143057293 35535989.391856715 1.0 1.0120178128090878 6.441835369337362 22.39530574055915 -6.907381615782275 0.9133629683061945 0.8176451607761492 7.105664759827329 0.9898958245007096 0.25757906538313174 0.1061755651655947 0.1483408266641302 0.20819047236191454 0.5648023580346638 1.2377085305958e-07 6.907381615782275 6.28801959905118 up QDSNPLYK(ub)SAITTTINPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QDSNPLYKSAITTTINPR 18 1 P26010;P26010-2 P26010 ITGB7 Integrin beta-7 1 80974600.0 4729700.0 8883900.0 67361000.0 True False 3932955.1112367082 8836040.667383919 81445873.65792589 1.0 2.246667052501763 20.708569346553116 21.907182289506405 -6.920582856698708 0.8203986806875452 0.6011461436436184 23.725937104660364 0.9943411745876581 0.677872803750676 0.09782999165921348 0.10384811456134317 0.585866294489077 1.7648292112399857 1.200651985254253e-07 6.920582856698708 23.124790961016746 up QDSNPLYK(ub)SAITTTINPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QDSNPLYKSAITTTINPR 18 1 P26010;P26010-2 P26010 ITGB7 Integrin beta-7 1 425998300.0 4979300.0 96389000.0 324630000.0 True False 6445802.006676813 91024867.41725925 265550670.98508564 1.0 14.121573595182127 41.1974601003906 22.619928443670677 -6.959429507380157 0.4434046270928201 0.0655385723089389 56.315127355023975 0.999748441116485 0.2654574469034253 0.07990560948827903 0.021889444666866844 0.35854586950450157 2.242013113178717 1.0979194848933075e-07 6.959429507380157 56.24958878271504 QDSSTGSYSINFVQNPNNNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QDSSTGSYSINFVQNPNNNR 20 0 Q99614 Q99614 TTC1 Tetratricopeptide repeat protein 1 0 5815700.0 1924000.0 1910500.0 1981200.0 False True 2522382.6320425035 1625460.8470706735 1776204.4290123477 1.0 0.64441485856349 0.7041772356218863 21.266355710763 -10.594595041750539 6.448499255473646 1.0007917160659452 0.6742960470926945 0.9753713310167186 0.02439788826814706 0.00027834051919538717 1.749873926918305e-05 0.0236772991179551 0.007874384578763579 2.5433431426400383e-11 10.594595041750539 -0.32649566897325066 QDSSTGSYSINFVQNPNNNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QDSSTGSYSINFVQNPNNNR 20 0 Q99614 Q99614 TTC1 Tetratricopeptide repeat protein 1 0 5982100.0 1924000.0 1380300.0 2677800.0 False True 2635354.7941449783 1319313.7819582932 2045358.7910221345 1.0 0.5006209353250802 0.7761227427769308 21.329565772285893 -10.117729445889871 5.369713302880711 1.000006617932171 0.6383718390508282 0.6967199075908639 0.11247314191254984 8.911155282531584e-06 1.4639407662579268e-06 0.1089036434075064 0.036300550460153375 7.625539132393306e-11 10.117729445889871 -0.36163477888134277 QDTEEDEEEDEK(ub)DKGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QDTEEDEEEDEKDKGK 16 2 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 1 2342700.0 687320.0 1019700.0 635680.0 True False 941440.7781245982 974646.282303028 485545.4762405522 1.0 1.0352709431649827 0.5157472328825458 19.8445108185666 -6.89064189660413 1.0185430481995617 1.0274864591098352 0.4704915033630619 0.9813071832117854 0.032407160213709645 0.11862524616678434 0.21880101414159717 0.024221704728174323 0.060528350202431705 1.2863468975197957e-07 6.89064189660413 -0.5569949557467733 QDVVNWLNEEK(ub)IVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QDVVNWLNEEKIVQR 15 1 Q9UPN7 Q9UPN7 PPP6R1 Serine/threonine-protein phosphatase 6 regulatory subunit 1 1 68000400.0 5208400.0 25298000.0 37494000.0 True False 6742376.472912964 23890144.061270736 30670476.720927835 1.0 3.5432824253062334 4.548911922101113 22.68482575440969 -9.189959085506873 0.321797308199085 3.4110943228216734e-19 4.903975825702863 0.9984480060311758 0.05883618779558699 0.6050210227329103 0.11970244261933265 1.0438532034521883 0.32037574068548147 6.457150584050463e-10 9.189959085506873 4.903975825702863 QDWGPITSISFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDWGPITSISFR 12 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 5468700.0 2073200.0 0.0 3395500.0 False True 2007387.4008123053 0.0 2506116.687183475 1.0 0.0 1.2484469545685875 20.93688763510133 -6.6933960339294165 1.8541509727095138 0.3750838260718953 1.2443446786102688 0.38648415718488627 0.42264032421625497 0.4093937881625094 2.731300806244031 0.18216668374116085 0.47238861009334626 2.0258345147732327e-07 6.6933960339294165 0.8692608525383735 QDWGPITSISFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QDWGPITSISFR 12 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 7334400.0 1722900.0 1630800.0 3980700.0 False True 2359902.6896218196 1558745.8636655686 3040540.645089934 1.0 0.6605127705140086 1.2884178057262134 21.170295940735674 -6.759883857745447 1.613154399328581 0.8027781630310058 1.2906797718055774 0.690418978422487 0.1427853965060699 0.2831019833800273 1.4519948988485272 0.06984215939581656 0.16784441569039663 1.738265626495494e-07 6.759883857745447 0.48790160877457156 QDYK(ub)EGEMTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QDYKEGEMTLK 11 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 1 9885400.0 3437100.0 3189700.0 3258600.0 True False 4506071.3849237515 2713809.1933532204 2921431.33069838 1.0 0.6022561476573548 0.6483322346984555 22.103438738170425 -10.647120854233382 10.134332950327888 1.000099425016348 0.6252941913568233 0.9887866793807725 0.0188104837657935 4.226743694978711e-05 1.4717445677664412e-06 0.01821790723857066 0.00607105752991859 2.253611996149044e-11 10.647120854233382 -0.3748052336595247 QDYK(ub)EGEMTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QDYKEGEMTLK 11 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 1 14733200.0 3021500.0 2571300.0 9140400.0 True False 2925584.136385481 3598033.499152363 6746255.033877735 1.0 1.2298513156410822 2.3059514679391997 21.480293278303662 -6.941283576069875 0.6475230358774834 0.9881378612120989 2.6074266174351313 0.9983271101607153 0.023282569883132632 0.08718612488885667 0.05198160587144339 0.02289048101116314 0.09210673449856979 1.1447652137145282e-07 6.941283576069875 1.6192887562230323 up QDYK(ub)EGEMTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QDYKEGEMTLK 11 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 1 13337300.0 3021500.0 5369300.0 4946500.0 True False 2512511.125145719 5340374.515177389 5980790.279968091 1.0 2.1255127834976895 2.3804035015451808 21.26069855373794 -10.48808417708575 0.31345097626505813 1.00957607902614e-14 2.4514838023387098 0.9990814883991559 0.01817648823988049 2.0331262925199223 0.15088420457903004 1.7061547513599638 0.08644189189602337 3.250242934776716e-11 10.48808417708575 2.4514838023386996 QDYQLGFTLIWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QDYQLGFTLIWK 12 0 A8MU58;Q13155-2;Q13155 A8MU58 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 0 38113900.0 9771900.0 12294000.0 16048000.0 False True 14824686.721582968 10100039.646539584 12876105.76591172 1.0 0.6812986902337124 0.868558372108171 23.821498281968033 -10.237421714234747 5.412285204000855 1.0000167891466873 0.7749285322032861 0.6582545154694772 0.07644844499812596 1.5488616632056974e-05 2.182359583009654e-06 0.0740264072212376 0.02467362952675597 5.788663251780854e-11 10.237421714234747 -0.2250882569434013 QEAEQLK(ub)NQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QEAEQLKNQIR 11 1 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5 P62873 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 1 16759200.0 5670200.0 0.0 11089000.0 True False 7433687.1102949055 0.0 9941616.653199036 1.0 0.0 1.3373735678800498 22.825646534639027 -6.706545223623827 1.8073760296118675 0.3830712029323889 1.3339431684042566 0.44875154250288307 0.42162877966221524 0.38205951809044264 2.4305888825368998 0.18579173951055195 0.4740117338401078 1.9654173085786394e-07 6.706545223623827 0.9508719654718678 QEAEQLK(ub)NQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QEAEQLKNQIR 11 1 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5 P62873 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 1 131107000.0 12754000.0 39152000.0 79201000.0 True False 19348750.442295674 32165019.704027798 63546887.63496858 1.0 1.6623822711422345 3.284288968659049 24.20573706319554 -6.955905800192329 0.4897433745688277 0.9644230970040744 4.050993680601914 0.9995869066615196 0.019503365251802927 0.08119749275796581 0.026792683290183864 0.02333914177201867 0.1337699247865022 1.1068638401104778e-07 6.955905800192329 3.0865705835978394 QEAEQLK(ub)NQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QEAEQLKNQIR 11 1 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5 P62873 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 1 25730300.0 5670200.0 4462100.0 15598000.0 True False 7766626.171393373 4264949.66780851 11914073.65089376 1.0 0.5491380135582548 1.5340088975540733 22.88885659616192 -6.782263590623554 1.527328449410384 0.7454589725775407 1.5423320811904955 0.7752218550373844 0.19085168737980507 0.24707729172842255 1.1386025399171598 0.0984108211672617 0.23174575175877815 1.650959461008737e-07 6.782263590623554 0.7968731086129548 QEAEQLK(ub)NQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QEAEQLKNQIR 11 1 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5 P62873 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 1 32871410.0 5756900.0 320510.0 26794000.0 True False 4787117.423912425 318783.34901374596 32396501.51854145 1.0 0.06659192177350229 6.767434063078481 22.19072576389625 -6.871663294669338 1.125311052567496 0.46643943593809745 7.172387230807883 0.9663126384892592 0.5439065110639955 0.13526739265866755 0.3191376268877491 0.37472928720781634 0.8898057768720884 1.3438064006346758e-07 6.871663294669338 6.705947794869785 up QEAEQLK(ub)NQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QEAEQLKNQIR 11 1 P62873;P62873-2;F6UT28;B1AKQ8;F6X3N5 P62873 GNB1 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 1 116631000.0 12754000.0 28439000.0 75438000.0 True False 16510304.418925567 26856344.650109842 61709058.059245616 1.0 1.6266413973157716 3.737608737759508 23.976863385287988 -6.948819892640238 0.5716519399090484 0.9738961215364874 4.493279426046106 0.9991053959148932 0.035027645742996855 0.08396309294438317 0.03795030579190788 0.037040108076356014 0.1759570165043825 1.1250714584534206e-07 6.948819892640238 3.519383304509619 QEAK(ub)PEAFVLSPLEMSST ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QEAKPEAFVLSPLEMSST 18 1 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 1 5021400.0 1742000.0 1854100.0 1425300.0 True False 2386064.47577991 1772179.7313112153 1088673.4949749247 1.0 0.7427208062900144 0.456263234303038 21.186201597114714 -6.969737440254649 0.2643832182451975 1.0762389994701327 0.1141972743636613 0.9999802608112064 0.0009866852334617427 0.07638800283956061 0.009334612515714486 0.005814795700284638 0.02685393425302061 1.072167305404443e-07 6.969737440254649 -0.9620417251064713 down QECPVCK(ub)AGISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QECPVCKAGISR 12 1 Q99942;A0A140TA09 Q99942 RNF5 E3 ubiquitin-protein ligase RNF5 1 19163700.0 9986800.0 7111900.0 2065000.0 True False 13092791.512308776 6050832.241969074 1851333.6088787084 1.0 0.4621498964739929 0.1414009844377523 23.64226939110537 -8.495516066776744 0.3177181690175608 1.158933963463272 5.552961489966282e-20 0.9985182363817281 0.013635886704271913 0.17193286733209584 0.08873617660240167 0.11501255338579458 0.09344168235692552 3.1950961596538945e-09 8.495516066776744 -1.158933963463272 QEDVIATANLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QEDVIATANLSR 12 0 Q9Y490;Q9Y4G6;H0YMT1;A0A1B0GVU7 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 5928800.0 1275400.0 2158100.0 2495300.0 False True 1672061.75099117 1836119.8922079147 2237110.2926077708 1.0 1.098117274149411 1.3379352115923049 20.673196697965253 -6.955943707072006 0.4892638192630776 0.994716582194891 1.4514925576237037 0.9995889199488811 0.002877979516284075 0.08118324312606452 0.026737293352676703 0.0034474152546273657 0.01977948515582322 1.1067672330268261e-07 6.955943707072006 0.45677597542881265 QEDVIATANLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QEDVIATANLSR 12 0 Q9Y490;Q9Y4G6;H0YMT1;A0A1B0GVU7 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 5017470.0 1168200.0 770570.0 3078700.0 False True 1131116.1304403497 1078262.6194694645 2272296.110979758 1.0 0.9532731347838626 2.0088972739652657 20.10931562615808 -6.896540395737323 0.982846338014787 0.9518486824865277 2.1122490268272065 0.9847661385449354 0.06010652113827132 0.11399808080008601 0.19211381149724252 0.04614749797486237 0.11811787497834299 1.2689941039478947e-07 6.896540395737323 1.1604003443406787 up QEEEMMAK(ub)EEELVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QEEEMMAKEEELVK 14 1 P35579;P35579-2 P35579 MYH9 Myosin-9 1 5521800.0 2488500.0 1726000.0 1307300.0 True False 3262447.598668281 1468487.5278953055 1172033.1365070876 1.0 0.45011834933218137 0.3592496434227809 21.63752329866998 -13.999999999999998 0.25332871835499426 4.8892549902598 0.32385247383954324 0.9995490447117572 0.006011315528361232 14.132461440095065 0.1592645720266004 28.02563240073765 0.04117343354100205 1.0000000000000041e-14 13.999999999999998 -4.5654025164202565 QEEIDVIQEVLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QEEIDVIQEVLEK 13 0 Q9NU22 Q9NU22 MDN1 Midasin 0 6329900.0 1673600.0 1411600.0 3244700.0 False True 1620472.4840823251 1975259.2413967527 2394815.7310865014 1.0 1.2189403157409018 1.4778502903384303 20.62798309296357 -6.968907304568421 0.28307023205644316 0.9450287372386558 1.7596846952648917 0.9999725600574035 0.001023073281520745 0.07665887623363007 0.010293402133972656 0.004699365047846383 0.023673978336289935 1.0742186681603784e-07 6.968907304568421 0.8146559580262359 QEEIDVIQEVLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QEEIDVIQEVLEK 13 0 Q9NU22 Q9NU22 MDN1 Midasin 0 22722600.0 4989500.0 8049500.0 9683600.0 False True 7569436.281310509 6613003.83396944 7769632.215527337 1.0 0.8736454853708763 1.0264479317582904 22.851754431696275 -6.687147723365328 1.877080294057417 0.9205710381306047 1.0258950649218397 0.35691840561111376 0.05347062913335112 0.42280142298573636 2.8861422702978308 0.022810436767385305 0.05960279770671569 2.0551914127238008e-07 6.687147723365328 0.10532402679123498 QEEIDVIQEVLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QEEIDVIQEVLEK 13 0 Q9NU22 Q9NU22 MDN1 Midasin 0 6297800.0 1673600.0 2291300.0 2332900.0 False True 1391672.5530510936 2278956.3121125586 2820698.6038891287 1.0 1.6375664714491853 2.026840723203923 20.408388368397848 -9.009616718152692 0.13188568528730413 2.534281632744545e-16 2.8329223277134026 0.9998982649114595 0.004269271810629989 0.4880092024982752 0.04320177249156785 0.5288617573957951 0.3425447684568833 9.78100051666936e-10 9.009616718152692 2.832922327713402 QEENK(ub)AGLLDLPDASVNGWSSDEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QEENKAGLLDLPDASVNGWSSDEEK 25 1 Q13488;Q13488-2 Q13488 TCIRG1 V-type proton ATPase 116 kDa subunit a isoform 3 1 19805600.0 3181600.0 3749000.0 12875000.0 True False 3080601.84951979 5245995.250776722 9502651.258279255 1.0 1.702912452511342 3.0846736197865186 21.55478080352184 -6.960381096463106 0.43002884506013994 0.9451311271571627 3.895445780883599 0.999784074185891 0.012724993842933217 0.07956526572752669 0.020630347303029584 0.01801832151691876 0.11472817581152049 1.0955164508432574e-07 6.960381096463106 2.950314653726436 QEENK(ub)AGLLDLPDASVNGWSSDEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QEENKAGLLDLPDASVNGWSSDEEK 25 1 Q13488;Q13488-2 Q13488 TCIRG1 V-type proton ATPase 116 kDa subunit a isoform 3 1 32256000.0 3576000.0 15192000.0 13488000.0 True False 5425053.440618578 12480868.904362217 10822090.887999577 1.0 2.3005983334496176 1.9948358124865984 22.371205918519202 -10.06897923271888 5.318001719557427 0.9999871572785715 2.1477170729694373 0.9494598324483556 0.12482702647572871 1.9007491219174453e-05 3.327762852618769e-06 0.12086459816050588 0.04028774955741873 8.531409089026872e-11 10.06897923271888 1.1477299156908658 QEENK(ub)AGLLDLPDASVNGWSSDEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QEENKAGLLDLPDASVNGWSSDEEK 25 1 Q13488;Q13488-2 Q13488 TCIRG1 V-type proton ATPase 116 kDa subunit a isoform 3 1 22039700.0 3181600.0 3835100.0 15023000.0 True False 2645641.3687782953 3814439.555092249 18164239.84149614 1.0 1.441782548499263 6.865722639453595 21.335186078956117 -6.9230666062425845 0.8016545622438419 0.8930301964711141 7.805203437563908 0.9949912556424696 0.18875758182923066 0.09640077244172901 0.09650937107591548 0.1653333856759635 0.5107526723764992 1.1938050006797234e-07 6.9230666062425845 6.912173241092794 up QEENK(ub)AGLLDLPDASVNGWSSDEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QEENKAGLLDLPDASVNGWSSDEEK 25 1 Q13488;Q13488-2 Q13488 TCIRG1 V-type proton ATPase 116 kDa subunit a isoform 3 1 21338600.0 3576000.0 8644700.0 9117900.0 True False 4629202.49349834 8163614.845697968 7458535.757554482 1.0 1.763503509981183 1.6111923745029315 22.14233224061165 -10.04419164627989 4.894568678844343 0.9999855819999809 1.6873479422500797 0.964480664607425 0.06218076070531845 43044018.15955726 2.1127335831692946 6994.427862188424 0.021286128296517416 9.032507975659902e-11 10.04419164627989 0.6873623602500988 QEEPLPEHPQDGAK(ub)LSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QEEPLPEHPQDGAKLSR 17 1 J3KRZ3;I3L345;J3KSS8;Q96FL8;Q96FL8-3 J3KRZ3 SLC47A1 Multidrug and toxin extrusion protein 1 1 3633990.0 757950.0 983640.0 1892400.0 True False 993679.7899982409 836884.7461986891 1696592.6011825982 1.0 0.8422076755734065 1.7073836242413682 19.922421497444706 -6.859665068783627 1.1874289169905656 0.9144638068784432 1.749011903123235 0.9532314377942921 0.0813597655422578 0.14714793809757942 0.39443593062520477 0.05344765734207893 0.12471594513163292 1.3814492380796039e-07 6.859665068783627 0.8345480962447918 QEIEEFQK(ub)LQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QEIEEFQKLQR 11 1 Q96AP4 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 11707300.0 4233600.0 5134700.0 2339000.0 True False 5550290.598240717 4368622.77490384 2096982.7172722977 1.0 0.7870980262346207 0.3778149414261266 22.404131878384273 -6.960811324004579 0.4238439252047703 1.0173596716278532 0.1320163224305665 0.9997991170174543 0.003659390922396265 0.0794125519636718 0.020069750851710717 0.005308693605033902 0.034034600703809696 1.0944317307002343e-07 6.960811324004579 -0.8853433491972867 down QEIEEFQK(ub)LQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QEIEEFQKLQR 11 1 Q96AP4 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 16719500.0 6433300.0 3744900.0 6541300.0 True False 6229078.412910387 5240258.099395503 4827937.295206381 1.0 0.8412573661835024 0.7750644598083721 22.570587302802437 -13.999999996464192 0.1199445865963282 1.7566221824006318 0.6693376785364161 0.9996932104809748 0.001653181378657834 11.96400044222258 0.10657958717689968 2.1579418462385282 0.09382051671473671 1.0000000081414991e-14 13.999999996464192 -1.0872845038642156 QEIEEFQK(ub)LQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QEIEEFQKLQR 11 1 Q96AP4 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 64541000.0 10462000.0 16792000.0 37287000.0 True False 15871618.874650877 13795336.403505156 29917208.106527343 1.0 0.8691826909691093 1.884950006852116 23.91994595201388 -6.874542672237803 1.1098413197019135 0.9235433971565821 1.9497931363327163 0.9690076975326246 0.07942775766461817 0.13257109390932875 0.3024674738754912 0.05537582285203886 0.13223612656332306 1.3349264179758603e-07 6.874542672237803 1.0262497391761343 QEIEEFQK(ub)LQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QEIEEFQKLQR 11 1 Q96AP4 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 22937500.0 6433300.0 9182200.0 7322000.0 True False 5349573.9935131455 9132733.666076 8852996.34689707 1.0 1.7071889606817827 1.654897447466312 22.350992578236713 -10.292054640074992 4.867704332325169 0.9997561594282459 1.6810432040746088 0.9955979155885171 0.021347920877921752 5.651187229409449e-05 8.218914106199741e-06 0.020677278620863604 0.006890011836086075 5.104407756345576e-11 10.292054640074992 0.6812870446463629 QEIEEFQK(ub)LQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QEIEEFQKLQR 11 1 Q96AP4 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 60528000.0 10462000.0 17957000.0 32109000.0 True False 13543265.236851122 16957677.164528362 26265491.46616187 1.0 1.252111427190147 1.9393765836242849 23.69107227410633 -6.953581571224746 0.518036048963495 0.988141793640949 2.23391370806062 0.999453195656127 0.009282865302659055 0.08207868524088 0.03025136111642326 0.010549481964906529 0.05675782659797759 1.1128033612297268e-07 6.953581571224746 1.245771914419671 QEILVEPEPLFGAPK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 QEILVEPEPLFGAPKR 16 1 O94888;C9JD50 O94888 UBXN7 UBX domain-containing protein 7 1 112574000.0 40797000.0 44966000.0 26811000.0 True False 53485262.07870995 38257248.07609515 24036854.909272194 1.0 0.7152857925571168 0.44941080916644083 25.672638074321256 -6.971950027948325 0.20636391001789597 1.1458237849466097 0.011480678309790096 0.9999938618142312 0.0005569721308207981 0.07567490511423017 0.0067162796677623345 0.008196488726111633 0.027787647591077255 1.0667188560687246e-07 6.971950027948325 -1.1343431066368197 down QEILVEPEPLFGAPK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 QEILVEPEPLFGAPKR 16 1 O94888;C9JD50 O94888 UBXN7 UBX domain-containing protein 7 1 176059000.0 64483000.0 48843000.0 62733000.0 True False 62436022.46120967 68346264.6128801 46301345.35034047 1.0 1.0946607730391915 0.7415806376696502 25.895875296366118 -6.835342445492955 1.3037017154012676 1.0504283642263263 0.7309885094568275 0.9161613376606882 0.043207302191461405 0.17431767101204326 0.5774962521451585 0.026004600294960146 0.05986011420360047 1.461024687731062e-07 6.835342445492955 -0.3194398547694989 QEILVEPEPLFGAPK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 QEILVEPEPLFGAPKR 16 1 O94888;C9JD50 O94888 UBXN7 UBX domain-containing protein 7 1 290963000.0 72823000.0 157315000.0 60825000.0 True False 110477815.07443145 129240909.14229496 48802912.089455396 1.0 1.1698358539696172 0.4417440013325368 26.719181451833816 -6.845271692857065 1.2577706071596437 1.0903833446351363 0.4151992527617389 0.9331266533107929 0.0804298999947759 0.16273576649670865 0.49781141928788675 0.05009445554155561 0.11561910264326726 1.4280003278318992e-07 6.845271692857065 -0.6751840918733973 down QEILVEPEPLFGAPK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QEILVEPEPLFGAPKR 16 1 O94888;C9JD50 O94888 UBXN7 UBX domain-containing protein 7 1 128903000.0 40797000.0 48114000.0 39992000.0 True False 55880753.39747017 45988164.38827876 30546713.261093907 1.0 0.8229696557806383 0.5466410419312067 25.735848135844147 -6.964587256535444 0.3650666781535528 1.0224746205472783 0.3375915592893542 0.9999043819553444 0.001824228672117212 0.07810130365830711 0.01535549690800912 0.003671879918469175 0.023532394897223568 1.0849575428397453e-07 6.964587256535444 -0.6848830612579242 QEILVEPEPLFGAPK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QEILVEPEPLFGAPKR 16 1 O94888;C9JD50 O94888 UBXN7 UBX domain-containing protein 7 1 188472000.0 64483000.0 83491000.0 40498000.0 True False 53620471.58125813 83041217.41133413 48965944.55840457 1.0 1.5486849511476393 0.913194962938736 25.676280571800394 -6.678268170620565 1.907787244773925 1.347689706573753 0.9156297453473858 0.3163437820757673 0.23263288726692374 0.4423719455928379 3.111341329504812 0.09789326833341083 0.25878519237217185 2.0976442183848158e-07 6.678268170620565 -0.43205996122636714 QEILVEPEPLFGAPK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QEILVEPEPLFGAPKR 16 1 O94888;C9JD50 O94888 UBXN7 UBX domain-containing protein 7 1 279442000.0 72823000.0 155309000.0 51310000.0 True False 94270809.05593674 146665917.6224167 41972106.485059194 1.0 1.5557935599703052 0.44522908952817547 26.490307773926265 -6.770689367019425 1.5723634437536618 1.318515131566448 0.43889896438707277 0.732994106101113 0.23427645047267465 0.2653162138721001 1.2947216148101723 0.11744919777892726 0.27933884853134267 1.695550124099601e-07 6.770689367019425 -0.8796161671793753 down QEIQEGQINIAMASASSPASSGGSGK(ub)LPSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QEIQEGQINIAMASASSPASSGGSGKLPSR 30 1 J3KNN7;Q7Z569;Q7Z569-2 J3KNN7 BRAP BRCA1-associated protein 1 25176100.0 11320000.0 9112000.0 4744100.0 True False 10960652.796254719 12750469.118452255 3501477.8900506906 1.0 1.1632946828503792 0.31945888216139406 23.385830389323235 -6.8565443067607745 1.20316579210246 1.0879021648714857 0.28123192675431796 0.9492843400105292 0.08229562850766536 0.15040992549627355 0.41573526272795347 0.0534191412706314 0.12424305504093595 1.391411835647094e-07 6.8565443067607745 -0.8066702381171678 down QEIQEGQINIAMASASSPASSGGSGK(ub)LPSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QEIQEGQINIAMASASSPASSGGSGKLPSR 30 1 J3KNN7;Q7Z569;Q7Z569-2 J3KNN7 BRAP BRCA1-associated protein 1 14890900.0 2400600.0 8775700.0 3714600.0 True False 3288166.693775695 8387960.556640862 2837287.9845884047 1.0 2.550953567080031 0.8628783905509484 21.648852007695247 -6.66512482738237 1.9547964861649878 1.9940801946359819 0.869842924735291 0.25762866680559116 0.6595588028509487 0.47237564843205415 3.4751430998961315 0.2720996948645934 0.7315977159145661 2.1620969922329876e-07 6.66512482738237 -1.1242372699006908 QEISAAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QEISAAFK 8 0 P08758;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 0 14766100.0 2848200.0 4467800.0 7450100.0 False True 3734017.782008034 3801221.6553479964 6679235.11840546 1.0 1.0179977378961014 1.788752895229541 21.832297367256185 -6.911929416260093 0.88249265572398 0.9775664196769452 1.892582786315104 0.9916293079063934 0.03363711904960346 0.10315667078915212 0.1319496817497289 0.027804424944936842 0.0778186802088196 1.2248152462698987e-07 6.911929416260093 0.9150163666381587 QEISAAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QEISAAFK 8 0 P08758;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 0 8280940.0 2327700.0 841740.0 5111500.0 False True 2253808.437618561 1177851.1716161116 3772644.8082869477 1.0 0.5226048283236809 1.673897721437778 21.103933468222838 -6.794077388723602 1.4798774191324726 0.7345923535389679 1.6875790520596976 0.814307750648267 0.20351926816091898 0.22932166854612535 0.9919920587380329 0.10822129422768008 0.25265486252351027 1.6066549310394675e-07 6.794077388723602 0.9529866985207297 QEISAAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QEISAAFK 8 0 P08758;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 0 10306600.0 2848200.0 2812200.0 4646200.0 False True 3901256.5097108767 2687947.705298203 3548863.251492661 1.0 0.6889953784396011 0.9096718564029178 21.895507428779077 -10.04246390568481 5.687681317514321 1.0000007183143476 0.7993336186144687 0.5243741881513002 0.09009079487430831 8.206774807126025e-07 1.3803555723806807e-07 0.08723035030038431 0.029076679016203227 9.068513300765602e-11 10.04246390568481 -0.20066709969987884 QEISAAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QEISAAFK 8 0 P08758;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 0 4637940.0 2327700.0 1654300.0 655940.0 False True 1935585.6845943038 1645387.957547161 793094.0212761083 1.0 0.8500723944401521 0.4097436902889369 20.884338743657114 -6.9519271922096015 0.5372690477908394 1.0066018041553388 0.23297476276893597 0.9993439774004071 0.006416140173314397 0.08272097048357022 0.03283006670220131 0.007083794810132916 0.03644999155745261 1.1170505012806703e-07 6.9519271922096015 -0.7736270413864028 down QEISAAFK(ub)TLFGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QEISAAFKTLFGR 13 1 P08758;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 1 4870400.0 1528400.0 1714500.0 1627500.0 True False 1479881.778603864 2399108.7909993874 1201208.9260465624 1.0 1.6211489496564597 0.8116924901797193 20.497050499074142 -6.701715538872598 1.8250770234756428 1.385062549176358 0.8140461569803235 0.42561327846737307 0.26211330507177005 0.3919440157097314 2.53938658607597 0.11453245830675474 0.293889546634322 1.9873962276174708e-07 6.701715538872598 -0.5710163921960345 QEISAAFK(ub)TLFGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QEISAAFKTLFGR 13 1 P08758;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 1 10287400.0 2473400.0 2198500.0 5615500.0 True False 3201865.058003022 2076151.5423631826 4593536.619895723 1.0 0.6484194382814066 1.4346440392340192 21.61048107635006 -6.785124264941701 1.515622611915525 0.8022502369676696 1.4419343789342924 0.7851870801033265 0.14904163556287894 0.2426956053383019 1.1013525777102962 0.0774240079859917 0.1819435117948417 1.6401204174112655e-07 6.785124264941701 0.6396841419666228 QEK(ub)MATVWDEAEQDGIGEEVLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 QEKMATVWDEAEQDGIGEEVLK 22 1 P17980;E9PM69 P17980 PSMC3 26S protease regulatory subunit 6A 1 103461900.0 37411000.0 43728000.0 22322900.0 True False 49046183.288639314 37203952.850408986 20013140.44437701 1.0 0.758549398868854 0.40804684691974186 25.547637536338097 -6.965796124660655 0.34411791653962986 1.0362485085716888 0.11862650881861175 0.9999286250019995 0.002053174242727074 0.07769186394443107 0.013913304525633476 0.00488805055187372 0.03024795526776733 1.0819417391737964e-07 6.965796124660655 -0.917621999753077 down QEK(ub)MATVWDEAEQDGIGEEVLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 QEKMATVWDEAEQDGIGEEVLK 22 1 P17980;E9PM69 P17980 PSMC3 26S protease regulatory subunit 6A 1 377278200.0 120833900.0 154358000.0 102086300.0 True False 116998093.98563269 215993954.36633626 75346835.50664657 1.0 1.8461322488968086 0.6440005382985053 26.801909786173614 -6.717532402468869 1.7679895243763069 1.5161166578569063 0.6461008278499661 0.5009644622858802 0.35616655456762336 0.3601212868102062 2.1985062611893236 0.1600337998401583 0.40294651579696156 1.9163180819791986e-07 6.717532402468869 -0.8700158300069402 QEK(ub)MATVWDEAEQDGIGEEVLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 QEKMATVWDEAEQDGIGEEVLK 22 1 P17980;E9PM69 P17980 PSMC3 26S protease regulatory subunit 6A 1 578900000.0 222538000.0 240721000.0 115641000.0 True False 337606415.7070407 197762456.7882424 92784505.66274923 1.0 0.5857781356852281 0.2748303981973593 28.330767079674754 -7.957588562695895 0.25319402996615176 1.1689448323111982 4.25921553942671e-11 0.999614814665168 0.005829908267400028 0.10582670645123458 0.044610807054751137 0.06268178947283656 0.09359792243654694 1.102583368656367e-08 7.957588562695895 -1.168944832268606 down QEK(ub)MATVWDEAEQDGIGEEVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QEKMATVWDEAEQDGIGEEVLK 22 1 P17980;E9PM69 P17980 PSMC3 26S protease regulatory subunit 6A 1 132667400.0 37411000.0 54927400.0 40329000.0 True False 51242857.69426077 52500525.84737799 30804120.801826756 1.0 1.0245432868053743 0.6011397917270496 25.61084759786099 -6.893148601822693 1.0035474803670628 1.0210626170742823 0.5623915536050119 0.9828390237147868 0.025422922066899837 0.11662654469846352 0.2072115863442497 0.019217872650162445 0.048487839400212875 1.2789436152641592e-07 6.893148601822693 -0.45867106346927033 QEK(ub)MATVWDEAEQDGIGEEVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 QEKMATVWDEAEQDGIGEEVLK 22 1 P17980;E9PM69 P17980 PSMC3 26S protease regulatory subunit 6A 1 325152000.0 120833900.0 163302300.0 41015800.0 True False 100478741.6994026 162422558.09693152 49592014.14436778 1.0 1.6164867846657878 0.4935572769484894 26.58231506160789 -6.75763199512157 1.6212301618948357 1.3591371044255305 0.4899053233926001 0.6812991840942644 0.2592163963442752 0.2869072760775944 1.4856815615574435 0.1261832602082814 0.30397010619878245 1.7473021241745506e-07 6.75763199512157 -0.8692317810329304 QEK(ub)MATVWDEAEQDGIGEEVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 QEKMATVWDEAEQDGIGEEVLK 22 1 P17980;E9PM69 P17980 PSMC3 26S protease regulatory subunit 6A 1 598846700.0 222538000.0 292195700.0 84113000.0 True False 288079827.87979144 275934752.4343365 68805297.07226236 1.0 0.9578412847062558 0.23884107949749644 28.101893401767203 -6.9189367146040395 0.8325907284107539 1.01648119602755 0.125691023652546 0.9938799428169981 0.027326104753290795 0.09880186284004468 0.1088917995635211 0.02341246007152361 0.06943254232098671 1.2052115510149687e-07 6.9189367146040395 -0.8907901723750039 down QEK(ub)PAEKPAETPVATSPTATDSTSGDSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QEKPAEKPAETPVATSPTATDSTSGDSSR 29 2 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 193898600.0 70557000.0 79188500.0 44153100.0 True False 92500910.27496 67373884.4743554 39584560.758441895 1.0 0.7283591509973877 0.4279369861418265 26.46296422705896 -6.969827756082164 0.26227006240158646 1.0820401417103993 0.06531643764807679 0.9999810065502976 0.00101823103314981 0.07635865535047887 0.009230061300172782 0.00618062999345926 0.028249903193672377 1.0719443608048795e-07 6.969827756082164 -1.0167237040623225 down QEK(ub)PAEKPAETPVATSPTATDSTSGDSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QEKPAEKPAETPVATSPTATDSTSGDSSR 29 2 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 281559200.0 90302700.0 113507500.0 77749000.0 True False 87436090.21769889 158831636.68379283 57384204.47999649 1.0 1.8165455052751431 0.6562988388103924 26.381725555275704 -6.717574372222978 1.7677709539280022 1.4980681653227956 0.6583224202455343 0.5010651454912771 0.3437141594938326 0.3601055312281368 2.1978757494942194 0.15445275531668806 0.38888467650794983 1.9161328999979349e-07 6.717574372222978 -0.8397457450772613 QEK(ub)PAEKPAETPVATSPTATDSTSGDSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QEKPAEKPAETPVATSPTATDSTSGDSSR 29 2 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 745700500.0 286249000.0 406088500.0 53363000.0 True False 434260660.60504156 333618834.3910679 42815779.66016628 1.0 0.7682455830243693 0.09859465418882847 28.6939860249908 -7.206319555684849 0.6641645346781506 0.9982209614610972 2.7905299447167216e-23 0.9967097385795202 0.021923151350677413 0.08863033062718242 0.06939967368395641 0.020366092360054 0.05640682282604474 6.218425624506468e-08 7.206319555684849 -0.9982209614610972 down QEK(ub)PAEKPAETPVATSPTATDSTSGDSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QEKPAEKPAETPVATSPTATDSTSGDSSR 29 2 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 284191400.0 70557000.0 107210400.0 106424000.0 True False 96643829.63123043 102473490.03061749 81288843.07108076 1.0 1.0603210822835938 0.8411177762849361 26.526174288581853 -6.833353097027615 1.3130300548046658 1.0321632439609894 0.8348120178243067 0.9123840884144446 0.027366832848838774 0.1767117718274217 0.5946648406318281 0.016359442034517637 0.03764533359956968 1.4677324731378127e-07 6.833353097027615 -0.19735122613668266 QEK(ub)PAEKPAETPVATSPTATDSTSGDSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QEKPAEKPAETPVATSPTATDSTSGDSSR 29 2 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 576163700.0 90302700.0 416300000.0 69561000.0 True False 75090696.13791041 414057309.2709193 84105883.48627524 1.0 5.514096027428859 1.1200573148477366 26.16213083070998 -6.639887830704922 2.044718943879294 3.9521834795207496 1.1382714761207282 0.15423466073205638 1.931495763338332 0.5336493991304255 4.263972433136843 0.7692645171981627 2.1389907015698 2.2914594129850273e-07 6.639887830704922 -2.8139120034000213 QEK(ub)PAEKPAETPVATSPTATDSTSGDSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QEKPAEKPAETPVATSPTATDSTSGDSSR 29 2 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 599923400.0 286249000.0 256925900.0 56748500.0 True False 370554973.3113556 242627747.8089824 46420855.28878147 1.0 0.6547685641372206 0.12527386928302472 28.46511234708325 -7.44278386092771 0.5129439910318104 1.0112734532857075 7.274864192341062e-21 0.997245370430734 0.01888062935240583 0.11272649265390267 0.06668596828209553 0.02050245497850893 0.06598659319765887 3.6075813996019566e-08 7.44278386092771 -1.0112734532857075 down QEKPAEK(ub)PAETPVATSPTATDSTSGDSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QEKPAEKPAETPVATSPTATDSTSGDSSR 29 2 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 312341000.0 142219300.0 108160000.0 61961700.0 True False 186450879.55366018 92022949.60437778 55550497.66259552 1.0 0.4935506328780485 0.2979363669164575 27.47422036192089 -13.999999999999991 0.13168250407009457 3.40756784104844 0.029756840449093415 0.9996380671035907 0.005628063349326049 11.934493494954873 0.11301025919060222 7.425994277222102 0.23865941775410343 1.0000000000000205e-14 13.999999999999991 -3.3778110005993467 QEKPAEK(ub)PAETPVATSPTATDSTSGDSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QEKPAEKPAETPVATSPTATDSTSGDSSR 29 2 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 403824300.0 133400000.0 171123300.0 99301000.0 True False 129165290.01946825 239453726.0862204 73291089.13385542 1.0 1.853855056959413 0.5674209311403143 26.9446431925633 -6.72777136844445 1.7315383531897839 1.5151197666802378 0.5685157483438537 0.548842635062023 0.35900686294157336 0.3404212200168841 1.9985568233925 0.16438082339792795 0.4089047128872964 1.8716672082965357e-07 6.72777136844445 -0.9466040183363842 QEKPAEK(ub)PAETPVATSPTATDSTSGDSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QEKPAEKPAETPVATSPTATDSTSGDSSR 29 2 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 518782900.0 418018000.0 15497000.0 85267900.0 True False 634163867.2093114 12731439.271386348 68414662.19075178 1.0 0.020075945555542388 0.10788167810918643 29.24028043836503 -10.81927808046552 2.815135894189661 1.2900771541389595 0.06397881000875776 0.9934433963407195 0.03584654628594478 36385913.26843774 27232023.451444622 71705436.47107202 0.01288068446209136 1.5160793050608446e-11 10.81927808046552 -1.2260983441302018 QEKPAEK(ub)PAETPVATSPTATDSTSGDSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QEKPAEKPAETPVATSPTATDSTSGDSSR 29 2 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 299857000.0 142219300.0 155880000.0 1757700.0 True False 194801618.54207 148992706.17377257 1342567.460967814 1.0 0.764843266133313 0.006891972823510544 27.53743042344378 -7.302474699806954 0.8018357684768427 0.9896940468185617 8.044447449772059e-18 0.9890803501115218 0.04428032693335559 0.10357802419437266 0.13144078356046757 0.03794837510444148 0.06921924277092503 4.983394863139748e-08 7.302474699806954 -0.9896940468185617 down QEKPAEK(ub)PAETPVATSPTATDSTSGDSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QEKPAEKPAETPVATSPTATDSTSGDSSR 29 2 P54727;P54727-2;H0Y579 P54727 RAD23B UV excision repair protein RAD23 homolog B 1 817729000.0 418018000.0 330123000.0 69588000.0 True False 541132541.3666638 311751364.84856063 56923698.03317673 1.0 0.5761090694365066 0.10519363313359865 29.01140676045748 -7.708636177082659 0.4717438263459495 1.0248455796819476 4.359888063008013e-21 0.9965040772604102 0.0216089741980047 0.11622102240714957 0.08470605259818272 0.029051565202141756 0.0757796521627352 1.9559773568385814e-08 7.708636177082659 -1.0248455796819476 down QELEIVIGDEHISFTTSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QELEIVIGDEHISFTTSK 18 0 P61326;Q96A72;F5H6P7 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 0 29015300.0 5742300.0 10556000.0 12717000.0 False True 8711488.918362422 8672199.32559555 10203479.375940884 1.0 0.995489910721914 1.1712669867987302 23.054487886490517 -6.9010113832091085 0.9548465737178194 0.9928932546582863 1.19010180680968 0.9870629450561578 0.009306277290886572 0.11066483339663498 0.17324865289335423 0.0072956490591076185 0.019080300228505265 1.2559970425665987e-07 6.9010113832091085 0.19720855215139377 QELELSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QELELSVK 8 0 A0A087WYS1;E7EUC7;Q16851-2;Q16851;C9JVG3;C9JQU9;C9JNZ1;C9JWG0;C9JUW1;C9JTZ5;C9J3M0;F2Z3P4;C9J6Q0;F8WC70;F2Z3H1 A0A087WYS1 UGP2 UTP--glucose-1-phosphate uridylyltransferase 0 4506400.0 1401600.0 1200500.0 1904300.0 False True 1919809.3968158 1147457.9404773812 1454543.560289585 1.0 0.5976936785394203 0.7576499847860386 20.87253165322966 -10.098375334461249 5.119745529312903 1.0000078020622263 0.6776718316620466 0.8440953745613338 0.06530188857647337 5.815601633973796e-06 1.0242555463985883e-06 0.06322981177078398 0.021076093910706455 7.973053266394957e-11 10.098375334461249 -0.3223359704001797 QELILSNSEDK(ub)SIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QELILSNSEDKSIR 14 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 7025000.0 1840200.0 2402700.0 2782100.0 True False 2412520.020522147 2044226.5256512451 2494234.9797876272 1.0 0.8473407508588504 1.033871204620219 21.20210948409377 -6.689161620298025 1.8692818529427282 0.90421763475566 1.033221996155249 0.366544975662381 0.06457510334401875 0.41847886353961034 2.834370500971818 0.027641902091390422 0.07206059010183412 2.0456832053211987e-07 6.689161620298025 0.12900436139958893 QELILSNSEDK(ub)SIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QELILSNSEDKSIR 14 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 20175300.0 5589600.0 3958700.0 10627000.0 True False 8479831.854497084 3252239.0555357267 8526568.79202043 1.0 0.3835263612934703 1.005511540597183 23.015604227380543 -10.919993057884739 11.098442792124207 1.0395395562347505 0.6945189509458206 0.24335461970824546 0.25392438614460006 0.13893211163232597 0.0010015382293633729 0.1374967399911577 0.08195374322783146 1.2022836527409089e-11 10.919993057884739 -0.34502060528892986 QELILSNSEDK(ub)SIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QELILSNSEDKSIR 14 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 5659100.0 1840200.0 2197600.0 1621300.0 True False 2520571.6695351275 2100502.765508613 1238382.3317216327 1.0 0.8333437969236605 0.4913101050405876 21.265319545616663 -6.959536687084442 0.4419178437215239 1.0119879840025463 0.29928803440400376 0.9997526194900465 0.003330404583208952 0.07986708135915215 0.021746254503160777 0.004520479971530528 0.028329540823303183 1.0976485623480619e-07 6.959536687084442 -0.7126999495985425 down QELILSNSEDK(ub)SIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QELILSNSEDKSIR 14 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 7201200.0 2521100.0 3477800.0 1202300.0 True False 2096406.3536670113 3459064.4011107525 1453695.3711928912 1.0 1.6499970986350974 0.6934225173712639 20.999486955855875 -6.723749217845334 1.74581857165544 1.3938747527966486 0.6945986780630584 0.5300414123581627 0.2734055890615006 0.34814105801259226 2.0756547667671197 0.12425119372797927 0.3105506743598951 1.889081879342137e-07 6.723749217845334 -0.6992760747335902 QELILSNSEDK(ub)SIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QELILSNSEDKSIR 14 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 18960700.0 5589600.0 4975000.0 8396100.0 True False 7235847.387488338 4698136.876623531 6868095.951261059 1.0 0.6492863413270963 0.9491764521093734 22.786730549472992 -10.110319419925503 7.131944878246804 1.0000000906865627 0.7992313967182348 0.37405864018676116 0.1224296250538832 1.7654852833455775e-07 2.204320228945145e-08 0.11854202772117238 0.03951399157634234 7.756764033299496e-11 10.110319419925503 -0.20076869396832786 QEMLLSLK(ub)PSEAPELDEDEGFGDWSQRPEQR ddPTM_RPMI8226_Bortezomib_2h_R1 2 QEMLLSLKPSEAPELDEDEGFGDWSQRPEQR 31 2 P33241;P33241-3;E7EMG9;C9JU59;C9JDV1 P33241 LSP1 Lymphocyte-specific protein 1 1 521212100.0 305275400.0 190784200.0 25152500.0 True False 295584599.52630585 266965325.98645973 18564305.691174295 1.0 0.9031773861503257 0.0628053887818406 28.13899586361064 -7.048965615111006 0.8728574207725334 1.004385642985466 5.279738753561122e-24 0.9944979227650573 0.03121599422815299 0.07962357475916465 0.1066421377757367 0.027385964446086007 0.06172273298676266 8.933762132202516e-08 7.048965615111006 -1.004385642985466 down QEMLLSLK(ub)PSEAPELDEDEGFGDWSQRPEQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QEMLLSLKPSEAPELDEDEGFGDWSQRPEQR 31 2 P33241;P33241-3;E7EMG9;C9JU59;C9JDV1 P33241 LSP1 Lymphocyte-specific protein 1 1 467036000.0 302998000.0 138096000.0 25942000.0 True False 459670118.1209588 113451689.85102741 20814552.3292175 1.0 0.24681110513512527 0.04528149972920429 28.77602364269995 -10.056825624376012 0.327791849513883 1.4903452074795465 6.592120510720765e-18 0.9987349917495478 0.014613719002089484 1.518561012713239 0.1547683549366127 0.7575651147831916 0.06432116179848027 8.773530205779854e-11 10.056825624376012 -1.4903452074795465 QEMLLSLK(ub)PSEAPELDEDEGFGDWSQRPEQR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 QEMLLSLKPSEAPELDEDEGFGDWSQRPEQR 31 2 P33241;P33241-3;E7EMG9;C9JU59;C9JDV1 P33241 LSP1 Lymphocyte-specific protein 1 1 571020100.0 305275400.0 251106800.0 14637900.0 True False 253850021.0932683 249754037.82760262 17698617.211997356 1.0 0.9838645541645996 0.06972076321197003 27.919401139044915 -6.9640634228793585 0.9555333302102709 1.022965341034549 1.53610691304206e-19 0.9907812434564129 0.04174556104964716 0.09125673183170531 0.14788688000501032 0.03407780741702228 0.0791613957224321 1.086266977322662e-07 6.9640634228793585 -1.022965341034549 down QEMLLSLK(ub)PSEAPELDEDEGFGDWSQRPEQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QEMLLSLKPSEAPELDEDEGFGDWSQRPEQR 31 2 P33241;P33241-3;E7EMG9;C9JU59;C9JDV1 P33241 LSP1 Lymphocyte-specific protein 1 1 570901000.0 302998000.0 249868000.0 18035000.0 True False 392236883.9835041 235962626.1483752 14752815.054726982 1.0 0.6015819413818789 0.03761200350385056 28.5471499647924 -7.63583884394091 0.5991120391185597 1.0035826920327515 1.3932500325263281e-22 0.9916544029737014 0.036069048500980805 0.11828258709252104 0.11966942751306392 0.034925846009226574 0.07569429866077566 2.3129229000664704e-08 7.63583884394091 -1.0035826920327515 down QEMQEVQSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QEMQEVQSSR 10 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 72011000.0 1147000.0 37078000.0 33786000.0 False True 1503728.1075637995 31546106.92891198 30290148.818196617 1.0 20.978597640247646 20.143368116773384 20.520112303008784 -9.35269396639784 9.11425576325707 1.0000000000034848 20.560982878651693 0.9986344797372275 0.340981025107059 0.0 0.0 0.3301534579014087 0.11005115263380288 4.439213510938315e-10 9.35269396639784 19.560982878648208 QEMQEVQSSR ddPTM_RPMI8226_Bortezomib_2h_R1 2 QEMQEVQSSR 10 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 64263280.0 18457400.0 6179280.0 39626600.0 False True 17871479.940069962 8646698.728519503 29247204.687481854 1.0 0.4838266756595007 1.6365295311613326 24.09115577334154 -6.7849948629122165 1.5165412591251777 0.7096221777376701 1.6471099060792933 0.784617568833026 0.2187935710555564 0.24289387096721962 1.103650749802603 0.11360040606993715 0.26693758809601387 1.6406091791645647e-07 6.7849948629122165 0.9374877283416232 QEMQEVQSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QEMQEVQSSR 10 0 P22626;P22626-2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 71004000.0 1147000.0 35954000.0 33903000.0 False True 1571076.8965095056 34365433.39602147 25895809.6542025 1.0 21.873807368927565 16.48284034456605 20.583322364531675 -9.837909230176107 7.749444965120835 0.9999999737666947 19.178323856746818 0.9381206641591796 2.2008530716426895 7.230061784552096e-07 6.556109290067739e-08 2.1309668234801276 0.7103222744934581 1.452415148248449e-10 9.837909230176107 18.178323882980123 QENGASVILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QENGASVILR 10 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;E9PK06;E9PK72;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4 E9PI39;P29692 EEF1D Elongation factor 1-delta 0 28952000.0 12080000.0 16872000.0 0.0 False True 15836996.982886396 14354763.366540886 0.0 1.0 0.9064069016400506 0.0 23.9167954612054 -7.109651630297419 0.9795199717035524 0.999179646717435 1.7929214057207898e-18 0.9895652313661546 0.04606650088687405 0.08509945068931671 0.15509239554405035 0.038105573268077585 0.06722442934879222 7.768700337428643e-08 7.109651630297419 -0.999179646717435 down QENGASVILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QENGASVILR 10 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;E9PK06;E9PK72;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4 E9PI39;P29692 EEF1D Elongation factor 1-delta 0 26474800.0 9356800.0 3102000.0 14016000.0 False True 9059773.505653376 4340644.776716302 10344789.129012976 1.0 0.4791118424768238 1.1418374998621919 23.111043552669067 -6.697060452418216 1.8409627886932358 0.6756354664753462 1.1397882414587062 0.40386024870759085 0.2199919457694666 0.40164532155153354 2.64423601390074 0.09540050975475053 0.24627466670380715 2.0088131727068796e-07 6.697060452418216 0.46415277498335994 QENGASVILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QENGASVILR 10 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;E9PK06;E9PK72;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4 E9PI39;P29692 EEF1D Elongation factor 1-delta 0 25642000.0 12080000.0 13562000.0 0.0 False True 16546302.449725218 12962785.996463344 0.0 1.0 0.7834249395506858 0.0 23.98000552272829 -7.277183608157231 0.8337957036455508 0.98901523761171 1.3770682168901372e-17 0.9885251065769706 0.046014356753374605 0.10143154723791196 0.1376398901062709 0.03911958138174658 0.06906166014096408 5.2822188639611044e-08 7.277183608157231 -0.98901523761171 down QENGASVILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QENGASVILR 10 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;E9PK06;E9PK72;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4 E9PI39;P29692 EEF1D Elongation factor 1-delta 0 14507900.0 9356800.0 5151100.0 0.0 False True 7780593.7765227435 5123350.001886708 0.0 1.0 0.6584780222488886 0.0 22.891448828103343 -7.515566826515099 0.7091186657541974 0.9935785556957359 5.578608115148762e-17 0.987070779781701 0.04719142117740503 0.11955963221533605 0.14299032924781307 0.041817066797687076 0.07584248731996075 3.050936534013171e-08 7.515566826515099 -0.9935785556957358 down QENQEAVGGFFSQIGELYVVHHLWAYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QENQEAVGGFFSQIGELYVVHHLWAYK 27 0 Q9BPW8 Q9BPW8 NIPSNAP1 Protein NipSnap homolog 1 0 58159000.0 13264000.0 19245000.0 25650000.0 False True 20122457.728289932 15810579.388128696 20580266.257205646 1.0 0.7857181066853869 1.022751123898354 24.262303188831634 -6.668585760119535 1.9421243552975098 0.8630612172332264 1.0217928867032777 0.27290704710173674 0.09105160184745571 0.4643739365257527 3.3753720944850194 0.0377589665588934 0.10107854142012175 2.144935513635165e-07 6.668585760119535 0.15873166947005135 QENQEAVGGFFSQIGELYVVHHLWAYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QENQEAVGGFFSQIGELYVVHHLWAYK 27 0 Q9BPW8 Q9BPW8 NIPSNAP1 Protein NipSnap homolog 1 0 31364600.0 13264000.0 9048700.0 9051900.0 False True 17170509.472528517 8545131.89055342 7404547.080337294 1.0 0.4976632699352904 0.43123630619021497 24.033429510924083 -13.999999999999998 0.2851593413458348 5.212752952830934 0.41223536763299384 0.9996166442630537 0.004971481637695929 15.68437956175462 0.16924715230716345 38.65151205043563 0.025649096240364013 1.0000000000000041e-14 13.999999999999998 -4.80051758519794 QEPIASK(ub)SFLYPGSSTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QEPIASKSFLYPGSSTR 17 1 F5GZ90;Q9NZJ0 F5GZ90 DTL Denticleless protein homolog 1 90084000.0 0.0 11803000.0 78281000.0 True False 0.0 9696662.432740094 62808726.03821891 0.0 QEPIASK(ub)SFLYPGSSTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QEPIASKSFLYPGSSTR 17 1 F5GZ90;Q9NZJ0 F5GZ90 DTL Denticleless protein homolog 1 68326800.0 0.0 8829800.0 59497000.0 True False 0.0 8338413.867981987 48669156.49077303 0.0 QEPVKPEEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QEPVKPEEGR 10 1 P61586 P61586 RHOA Transforming protein RhoA 0 2942487.0 71987.0 1734200.0 1136300.0 False True 94375.6541230997 1475464.1198586556 1018726.5761592621 1.0 15.633948538614856 10.794378970136487 16.526127118311685 -9.520985711439387 7.440237304556251 1.0000642773876625 13.214163754382309 0.8946574028658715 1.9757460032848158 0.0 0.0 1.9130078986046795 0.6376692805320887 3.013105155603205e-10 9.520985711439387 12.214099476994646 QEPVKPEEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QEPVKPEEGR 10 1 P61586 P61586 RHOA Transforming protein RhoA 0 2214017.0 71987.0 1179400.0 962630.0 False True 98602.53927552736 1127290.2082457505 735276.6199871686 1.0 11.432669143496774 7.4569744895977585 16.589337179834576 -9.634630456485953 7.854795536949743 1.0000229236248621 9.444821816546845 0.8574646600481527 1.6230705459150532 0.0 0.0 1.5715311579849751 0.5238437661625298 2.3193673727403385e-10 9.634630456485953 8.444798892921984 QEQAGK(ub)NLGTTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QEQAGKNLGTTK 12 1 P30520 P30520 ADSS Adenylosuccinate synthetase isozyme 2 1 2985450.0 402480.0 214570.0 2368400.0 True False 610591.5852293523 176278.3070569382 1900284.7018934048 1.0 0.28870084573917604 3.112202571837956 19.21984818184666 -6.839944663122082 1.2825155185822614 0.6215782571187535 3.2050430278060165 0.9243736783313565 0.32974188697438345 0.1688695512291129 0.539562843753471 0.2015964777738644 0.4644676252882718 1.4456239573370827e-07 6.839944663122082 2.583464770687263 up QEQAGK(ub)NLGTTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QEQAGKNLGTTK 12 1 P30520 P30520 ADSS Adenylosuccinate synthetase isozyme 2 1 3715330.0 1301500.0 1673300.0 740530.0 True False 1082254.9162260976 1664285.600775956 895371.3991761399 1.0 1.5377944473372707 0.8273202419799263 20.04560892344238 -6.7043038711172125 1.8157592107079075 1.332542327021741 0.8292741002288967 0.4378616742955991 0.2268376441845833 0.38666514290726905 2.481370378192407 0.099558761964446 0.2546648159401905 1.9755868598089512e-07 6.7043038711172125 -0.5032682267928442 QEQAHDDAIWSVAWGTNKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QEQAHDDAIWSVAWGTNKK 19 1 H0YN81;Q9GZS3;H0YMF9;H0YM76 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 1 21728200.0 6150200.0 4268000.0 11310000.0 True False 7961555.138566414 4030482.048126475 9251696.050399892 1.0 0.5062430615599829 1.1620463451397745 22.924618830691337 -6.705199840400997 1.8117675276471807 0.694994393278095 1.1603406652791877 0.4426419373803706 0.20822656060553882 0.38474715901015416 2.458624160978641 0.09155582020924169 0.23400659334495438 1.971515335509186e-07 6.705199840400997 0.4653462720010927 QEQETTHK(ub)NIEEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QEQETTHKNIEEDR 14 1 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 1 3983650.0 1016600.0 945850.0 2021200.0 True False 984328.589458706 1323532.8375425888 1491787.085299734 1.0 1.3446046896498407 1.5155376987679343 19.908780472165073 -11.64241790564375 0.11729696892117121 1.5643420109190833e-11 1.8415895681603551 0.999788157804007 0.0031207072718688156 4.698182534701697 0.07942029066449262 1.4322916809239543 0.2367275505338607 2.278148837903949e-12 11.64241790564375 1.8415895681447116 QEQETTHK(ub)NIEEDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QEQETTHKNIEEDR 14 1 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 1 4417400.0 1725600.0 1488600.0 1203200.0 True False 2617861.3582582287 1222947.6995151138 965386.9926187064 1.0 0.4671552584926772 0.36876933515723626 21.319957263608977 -13.999999999999998 0.23757522836139885 4.48593998150084 0.32425542511635247 0.9995210226656093 0.00606885107157435 13.53907560347605 0.15428146917666802 22.359513392526733 0.048769736820660776 1.0000000000000041e-14 13.999999999999998 -4.161684556384487 QEQETTHK(ub)NIEEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QEQETTHKNIEEDR 14 1 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 1 3819200.0 1318400.0 1233000.0 1267800.0 True False 1805848.1084203438 1178521.9830142532 968371.751160603 1.0 0.6526141249194868 0.5362420829555157 20.784245120811708 -13.999999999999998 0.15277095824044656 2.6873285054513247 0.4122006475553942 0.9995572550256632 0.004145230836302009 11.969223774788693 0.1232325121395425 5.9908859750289265 0.11211603267783735 1.0000000000000041e-14 13.999999999999998 -2.2751278578959306 QEQETTHK(ub)NIEEDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QEQETTHKNIEEDR 14 1 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 1 3053210.0 1016600.0 1363000.0 673610.0 True False 845347.9430160974 1355657.2484656833 814458.7365792596 1.0 1.6036677674152315 0.9634597721659688 19.68918574759935 -8.708332413831917 18.37828760070167 0.9999981214037106 1.2835637697906033 0.2073407117440781 0.26136381960407007 0.0 0.0 0.2530644301559088 0.08435481005196958 1.9573459256352863e-09 8.708332413831917 0.2835656483868927 QEQETTHK(ub)NIEEDRK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QEQETTHKNIEEDRK 15 2 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 1 19125400.0 6208100.0 6448700.0 6468600.0 True False 8138879.219325912 5486579.096835724 5799291.323192645 1.0 0.6741197343004852 0.7125417599787113 22.95639870828159 -10.226592479039766 8.191904394909576 1.0000001415760444 0.6933307473058032 0.9883641436964294 0.015685726299294434 4.056414394797513e-08 3.8124574688294124e-09 0.015187646424507704 0.005062546394194584 5.934819581774415e-11 10.226592479039766 -0.3066693942702412 QEQETTHK(ub)NIEEDRK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QEQETTHKNIEEDRK 15 2 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 1 20121900.0 5847500.0 6150300.0 8124100.0 True False 5661874.31325968 8606146.863390805 5996154.492224206 1.0 1.5200172923718676 1.059040550967666 22.432848292843783 -10.360756550599591 3.259733065565276 0.9976171726112667 1.2895289216039207 0.34468099888792536 0.18819296904316965 29537712.609892864 41182267.2603543 672707.1715610124 0.07713737763296807 4.357560739491355e-11 10.360756550599591 0.29191174899265404 QEQETTHK(ub)NIEEDRK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QEQETTHKNIEEDRK 15 2 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 1 21629000.0 6326200.0 5796400.0 9506400.0 True False 9597307.90717036 4761987.132520088 7627455.873196862 1.0 0.4961794680946208 0.7947495221548765 23.194198348736474 -10.273111565692606 5.880116266135417 1.0000188569403723 0.6454644951247492 0.652781880370193 0.12189071415380874 3.0133733318815123e-05 3.72516474737606e-06 0.11802644549453561 0.0393400588312516 5.331979049490909e-11 10.273111565692606 -0.35455436181562305 QEQETTHK(ub)NIEEDRK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QEQETTHKNIEEDRK 15 2 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 1 21187700.0 6208100.0 6929900.0 8049700.0 True False 8503402.337594297 6623714.10388522 6148526.648775455 1.0 0.778948689114849 0.7230666508148477 23.01960876980448 -13.999999999999998 0.19310203784389926 2.1979442484594545 0.6842039716875272 0.9994879981656023 0.002705618866168251 12.402839830477474 0.1393536692218676 5.596595737161845 0.037503632198179704 1.0000000000000041e-14 13.999999999999998 -1.5137402767719272 QEQETTHK(ub)NIEEDRK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QEQETTHKNIEEDRK 15 2 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 1 19009400.0 5847500.0 7922400.0 5239500.0 True False 4862455.338172964 7879720.458726726 6335055.225289166 1.0 1.6205229479161611 1.3028510875062396 22.21325356827806 -10.133668733043926 4.710209588557501 0.9999616521318692 1.4616870177160968 0.7379650477713784 0.12968899395762434 90575682.08516149 2.8817121224491116 37671.6180659634 0.04439599215418916 7.350743472922363e-11 10.133668733043926 0.4617253655842276 QEQETTHK(ub)NIEEDRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QEQETTHKNIEEDRK 15 2 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 1 19399100.0 6326200.0 5141000.0 7931900.0 True False 8189390.6080450695 4854898.830697794 6488375.58816685 1.0 0.592827850454276 0.7922904033656446 22.965324670828924 -10.215672241099004 4.985010321579315 1.0000307647352016 0.6925591269148423 0.7600574692359863 0.08143024634100846 3.424338046936185e-05 5.38770693731929e-06 0.07885418477951169 0.026281498980795032 6.085941295896143e-11 10.215672241099004 -0.30747163782035924 QEQLQK(ub)EQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QEQLQKEQEK 10 1 C9JFL6;K7ER33;C9J0Y1;K7EIW5;C9JBM0;C9J1A8;Q16236-3;Q16236-2;Q16236 C9JFL6 NFE2L2 Nuclear factor erythroid 2-related factor 2 1 15035750.0 667650.0 1081100.0 13287000.0 True False 875295.6155317973 919804.0940947928 11912188.697903823 1.0 1.0508496532750868 13.609332077673457 19.739410818279023 -6.907785463704101 0.9106533763746021 0.5834076406133336 15.157873129340938 0.9900594064528611 0.5914500452311111 0.10590157790010486 0.1468340016247448 0.4789871666132255 1.3028359796813613 1.2365581275656243e-07 6.907785463704101 14.574465488727604 up QEQLQK(ub)EQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QEQLQKEQEK 10 1 C9JFL6;K7ER33;C9J0Y1;K7EIW5;C9JBM0;C9J1A8;Q16236-3;Q16236-2;Q16236 C9JFL6 NFE2L2 Nuclear factor erythroid 2-related factor 2 1 12814700.0 800590.0 334110.0 11680000.0 True False 775175.7086708097 467521.8653606327 8620657.60751082 1.0 0.6031172805482906 11.12090782913286 19.564163836818743 -6.898127619251711 0.9729982210076022 0.5399610845893785 12.184007242879964 0.9856124530196065 0.5838216481365169 0.11279774173960787 0.18528097499408758 0.45154549516624726 1.1642255618825645 1.2643647540003639e-07 6.898127619251711 11.644046158290585 up QEQLQK(ub)EQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QEQLQKEQEK 10 1 C9JFL6;K7ER33;C9J0Y1;K7EIW5;C9JBM0;C9J1A8;Q16236-3;Q16236-2;Q16236 C9JFL6 NFE2L2 Nuclear factor erythroid 2-related factor 2 1 18038850.0 667650.0 1184200.0 16187000.0 True False 914498.2475628353 1131878.1283742737 12363963.98172953 1.0 1.2377039883791598 13.51994278248193 19.802620879801914 -6.911087635039044 0.8882807900269007 0.6326769566031267 15.144786056940797 0.9913259716739805 0.5445325894065285 0.10370336580118815 0.1348928210797243 0.4482281102866541 1.2468617598906275 1.2271915747009306e-07 6.911087635039044 14.51210910033767 up QEQLQK(ub)EQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QEQLQKEQEK 10 1 C9JFL6;K7ER33;C9J0Y1;K7EIW5;C9JBM0;C9J1A8;Q16236-3;Q16236-2;Q16236 C9JFL6 NFE2L2 Nuclear factor erythroid 2-related factor 2 1 10353690.0 800590.0 1555300.0 7997800.0 True False 665726.057150558 1546921.2901971196 9670103.002350917 1.0 2.3236604209519083 14.525648948969959 19.34456911225302 -6.9275597430993425 0.7665676522236802 0.7966779415388624 16.881704541755642 0.9960363144994405 0.3832929244567834 0.09392507158314574 0.08403678643042875 0.3442558120509228 1.119252066369107 1.1815177675628343e-07 6.9275597430993425 16.08502660021678 QEQMCNVGVSMGLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QEQMCNVGVSMGLTR 15 0 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 8039200.0 2327700.0 2771500.0 2940000.0 False True 3188313.5937272687 2649045.965875101 2245632.5512006404 1.0 0.8308611709609963 0.7043323955393623 21.604362105134697 -6.9743220900023575 0.11497610701788585 1.2459486600727212 0.2860051017719784 0.9999995376864692 8.215324602551975e-05 0.07492362195444909 0.003410743959505179 0.009457123864471456 0.018781356061780326 1.0609084535996766e-07 6.9743220900023575 -0.9599435583007427 QETAQISSNPPTSVPTAPALSSVIAPK(ub)NSTVTLVPEQIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QETAQISSNPPTSVPTAPALSSVIAPKNSTVTLVPEQIGK 40 1 I3NI44;J3KQU4;I3L4I4;O75674-2;O75674-3;O75674;I3L3T4;I3L367;I3L1G1 I3NI44 TOM1L1 TOM1-like protein 1 1 128646000.0 50215000.0 38514000.0 39917000.0 True False 48620952.31130126 53892841.04785668 29461540.215668656 1.0 1.10842833153085 0.6059432984166526 25.53507481511287 -6.850225302342324 1.2339865007412067 1.0578723681623938 0.585766342136019 0.9406372112314006 0.05260374630034049 0.15720687238592587 0.4605366368994526 0.03335528466238592 0.0771980720423249 1.4118049415275068e-07 6.850225302342324 -0.47210602602637486 QETAQISSNPPTSVPTAPALSSVIAPK(ub)NSTVTLVPEQIGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QETAQISSNPPTSVPTAPALSSVIAPKNSTVTLVPEQIGK 40 1 I3NI44;J3KQU4;I3L4I4;O75674-2;O75674-3;O75674;I3L3T4;I3L367;I3L1G1 I3NI44 TOM1L1 TOM1-like protein 1 1 268771000.0 94175000.0 125370000.0 49226000.0 True False 142870360.11472458 102996743.97971909 39496459.52347776 1.0 0.7209105086388313 0.2764496393217053 27.090131405058003 -7.071102487960453 0.3940112543487799 1.0280883058181827 6.798525261194234e-13 0.9998550706460725 0.003586900222123725 0.07415618750173016 0.018220990087322336 0.006212714375241407 0.035658689796198545 8.489801029148609e-08 7.071102487960453 -1.0280883058175028 down QETAQISSNPPTSVPTAPALSSVIAPK(ub)NSTVTLVPEQIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QETAQISSNPPTSVPTAPALSSVIAPKNSTVTLVPEQIGK 40 1 I3NI44;J3KQU4;I3L4I4;O75674-2;O75674-3;O75674;I3L3T4;I3L367;I3L1G1 I3NI44 TOM1L1 TOM1-like protein 1 1 109152000.0 50215000.0 42362000.0 16575000.0 True False 41755997.401685305 42133787.49780133 20040755.865858935 1.0 1.0090475648918587 0.4799491597116077 25.315480090547148 -6.9030106505463955 0.9420352718272944 1.020217944087256 0.4208862217804344 0.9880056201377841 0.027085593174039274 0.10922311152143056 0.16518369869245259 0.021435949207782794 0.056664397046056865 1.2502283695045745e-07 6.9030106505463955 -0.5993317223068217 down QETAQISSNPPTSVPTAPALSSVIAPK(ub)NSTVTLVPEQIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QETAQISSNPPTSVPTAPALSSVIAPKNSTVTLVPEQIGK 40 1 I3NI44;J3KQU4;I3L4I4;O75674-2;O75674-3;O75674;I3L3T4;I3L367;I3L1G1 I3NI44 TOM1L1 TOM1-like protein 1 1 271201000.0 94175000.0 138920000.0 38106000.0 True False 121911393.96678038 131188979.87950543 31171099.000578146 1.0 1.0761010567663027 0.2556865112138079 26.861257727150452 -6.884202086608661 1.0560508421705315 1.0504009777409617 0.19263965831675683 0.9769212777899825 0.056226877233532466 0.12397449248419719 0.25032680556986303 0.040845249814747034 0.09992100259518952 1.305563239974724e-07 6.884202086608661 -0.8577613194242049 down QETEVELYNEFPEPIK(ub)LDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QETEVELYNEFPEPIKLDK 19 1 P51149;C9J8S3;C9J4V0;C9J4S4 P51149 RAB7A Ras-related protein Rab-7a 1 14562500.0 4365700.0 7725100.0 2471700.0 True False 5723474.977498938 6572545.19220395 2215952.1942205834 1.0 1.1483487248643551 0.38716901933393566 22.448459906990006 -6.856135124555553 1.2049967177247676 1.0798063975197627 0.35291997151586585 0.948775985759867 0.07456838930541271 0.15084138046417453 0.41839032860181313 0.04833301162052225 0.11238528841171992 1.3927234094321806e-07 6.856135124555553 -0.7268864260038969 down QETEVELYNEFPEPIK(ub)LDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QETEVELYNEFPEPIKLDK 19 1 P51149;C9J8S3;C9J4V0;C9J4S4 P51149 RAB7A Ras-related protein Rab-7a 1 50669800.0 25953000.0 18174000.0 6542800.0 True False 25129136.220953938 25430972.976157997 4829044.400207347 1.0 1.012011425802705 0.19216913616714956 24.582857745650415 -6.9035759357438975 0.9383797298323165 1.0308230067152189 0.0995787379997869 0.9882630481346005 0.041566559414715265 0.10882091860935407 0.16294490264602346 0.03298524484875041 0.08746943197882197 1.248602109282357e-07 6.9035759357438975 -0.931244268715432 down QETEVELYNEFPEPIK(ub)LDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QETEVELYNEFPEPIKLDK 19 1 P51149;C9J8S3;C9J4V0;C9J4S4 P51149 RAB7A Ras-related protein Rab-7a 1 31890100.0 17499000.0 9583000.0 4808100.0 True False 26547262.348261856 7872838.777679248 3857776.9275349057 1.0 0.29655934666252737 0.1453173166003495 24.662059756870804 -13.999999999999998 0.2160245590288615 5.172387575988494 0.06127019200166688 0.9994942346833744 0.008375152277343588 12.89450806223336 0.14727184866479476 22.903647710617616 0.08595146079326649 1.0000000000000041e-14 13.999999999999998 -5.111117383986827 QETEVELYNEFPEPIK(ub)LDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QETEVELYNEFPEPIKLDK 19 1 P51149;C9J8S3;C9J4V0;C9J4S4 P51149 RAB7A Ras-related protein Rab-7a 1 13262800.0 4365700.0 5833900.0 3063200.0 True False 5979817.268606409 5576139.007872542 2339735.2485842905 1.0 0.9324932113138059 0.3912720311484641 22.511669968512898 -6.930055791834179 0.7463359443507097 1.0082133534230717 0.28000481422502654 0.9965491578438036 0.016004361816085232 0.09260893225619539 0.07753887083231263 0.014585563900137034 0.04895619703899212 1.1747466308959624e-07 6.930055791834179 -0.7282085391980452 down QETEVELYNEFPEPIK(ub)LDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QETEVELYNEFPEPIKLDK 19 1 P51149;C9J8S3;C9J4V0;C9J4S4 P51149 RAB7A Ras-related protein Rab-7a 1 51541200.0 25953000.0 18734000.0 6854200.0 True False 21581069.41284355 18633076.223592125 8287381.52975989 1.0 0.8633991146195478 0.38401162478203316 24.36326302108469 -6.947882508995783 0.581625578325041 1.0056961061552796 0.2179370305038389 0.9990244686244728 0.00824991150056227 0.0843473169012905 0.039568318080583954 0.008628625624108531 0.04006389272715006 1.1275024415766809e-07 6.947882508995783 -0.7877590756514408 down QETEVELYNEFPEPIKLDK(ub)NDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QETEVELYNEFPEPIKLDKNDR 22 2 P51149;C9J8S3;C9J4V0;C9J4S4 P51149 RAB7A Ras-related protein Rab-7a 1 31509300.0 12881000.0 7634300.0 10994000.0 True False 16674708.422469847 7209444.493910959 8993204.807966096 1.0 0.43235805456099846 0.53933205787559 23.991158198566847 -9.958588274313438 5.821473931113825 1.0000004451873372 0.4858450562183485 0.9685548299462713 0.043671953978089664 2.523286158488838e-07 4.51889918563559e-08 0.04228522447222476 0.014095062537668379 1.1000482277375846e-10 9.958588274313438 -0.5141553889689887 QETK(ub)EAQLYAAQAHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QETKEAQLYAAQAHLK 16 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 1 198639000.0 70933000.0 55647000.0 72059000.0 True False 92993849.91614908 47344684.51030712 64603025.918736525 1.0 0.5091162969701436 0.694702133280727 26.470631971949828 -10.095981758158135 5.1393765691594195 1.000008992738284 0.6019092151246469 0.8598454861646696 0.07576510041084913 7.806947878607491e-06 1.3732438133710104e-06 0.07336089939273577 0.02445308100918458 8.017117372937563e-11 10.095981758158135 -0.39809977761363713 QETK(ub)EAQLYAAQAHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QETKEAQLYAAQAHLK 16 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 1 125431000.0 25564000.0 77841000.0 22026000.0 True False 24752484.813026145 108923317.23545249 16256729.83416383 1.0 4.400500315755408 0.6567716314932805 24.56107002364582 -6.667562498375315 1.9458761938189846 3.1749931921760717 0.6719897150246612 0.2684267601902903 1.4452615014632506 0.4666900607463012 3.404361512899607 0.5984232817737387 1.604016370953733 2.1499952559305023e-07 6.667562498375315 -2.5030034771514105 QETK(ub)EAQLYAAQAHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QETKEAQLYAAQAHLK 16 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 1 458293000.0 164552000.0 164872000.0 128869000.0 True False 249637414.3626027 135449303.44918436 103397985.66471082 1.0 0.5425841466713874 0.4141926639030295 27.895258933163834 -13.999999999999998 0.17822810697748667 3.3606349958224335 0.3103170288917939 0.9995003819695855 0.005619651424421289 12.182320957071607 0.133813621443355 9.954944669244561 0.09732494981056355 1.0000000000000041e-14 13.999999999999998 -3.0503179669306397 QETK(ub)EAQLYAAQAHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QETKEAQLYAAQAHLK 16 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 1 216612000.0 70933000.0 79824000.0 65855000.0 True False 97158846.99224827 76297111.73733157 50301405.32629882 1.0 0.7852821858149353 0.5177233662551808 26.53384203347272 -6.968155510649584 0.2989775144725457 1.0469711313019996 0.24766283587473445 0.9999642089145445 0.0011802391769683855 0.0769058574060459 0.011160911704509786 0.004461552077705945 0.024022283812087143 1.0760798257332548e-07 6.968155510649584 -0.7993082954272651 QETK(ub)EAQLYAAQAHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QETKEAQLYAAQAHLK 16 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 1 205392000.0 25564000.0 119520000.0 60308000.0 True False 21257598.677221652 118876122.03713746 72918123.96731345 1.0 5.592170773480538 3.430214535259247 24.341475299080095 -9.128268994931286 10.938439937107326 1.0000000066675931 4.51119265621934 0.7786069360287584 0.8826149383121792 0.0 0.0 0.8545882392989445 0.28486274643298143 7.442708418700095e-10 9.128268994931286 3.5111926495517465 QETK(ub)EAQLYAAQAHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QETKEAQLYAAQAHLK 16 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 1 421715000.0 164552000.0 183137000.0 74026000.0 True False 213015807.80484846 172945264.95963868 60554027.570902064 1.0 0.8118893463440993 0.2842701121335456 27.666385255256284 -6.952952342078431 0.5254327119398322 1.008603786639086 0.06379018963699774 0.9994130721839843 0.007339571295826082 0.08232143844318102 0.0312202717389232 0.008244687903692467 0.04360693589272209 1.1144168189938712e-07 6.952952342078431 -0.9448135970020882 down QEVENNTLGSPAASELLEHLKPTYWFSAHLHVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QEVENNTLGSPAASELLEHLKPTYWFSAHLHVK 33 1 Q9UK59 Q9UK59 DBR1 Lariat debranching enzyme 0 33627400.0 8178400.0 11852000.0 13597000.0 False True 12407230.721128346 9736917.999901349 10909546.990223186 1.0 0.7847777009030946 0.8792894430217417 23.564677807824328 -10.116026019549162 4.628530799712723 1.000013605718466 0.8320335719591967 0.8081078664548683 0.03858425715971686 53801187.87105637 0.8845972714781399 7801.377976260578 0.013208417505198203 7.65550739688315e-11 10.116026019549162 -0.1679800337592694 QEVISTSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QEVISTSSK 9 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;D6RF23;H0Y9P0;D6RHJ5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 6763500.0 4817700.0 1945800.0 0.0 False True 4664764.750575654 2722768.087212951 0.0 1.0 0.5836881885366134 0.0 22.153372895473936 -7.692863816773785 0.6492194204121989 0.9999617298897368 4.758707500484694e-19 0.9874488474586872 0.04594989765878456 0.12028231078808474 0.1507868983161925 0.04276003751017181 0.07782044942553645 2.0283186467205434e-08 7.692863816773785 -0.9999617298897368 down QEVPIIIVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QEVPIIIVFR 10 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 3179020.0 791120.0 1267200.0 1120700.0 False True 1037165.9812169785 1078138.6995069133 1004740.7145134956 1.0 1.0395044949718257 0.9687366657885982 19.98421536136998 -6.755175494014653 1.6303565620048837 1.0230828827887954 0.9685354599084227 0.6710997896774399 0.01660625500038799 0.2910861510557736 1.523696898859951 0.00804066845602362 0.019418263990682125 1.7572133982828742e-07 6.755175494014653 -0.05454742288037273 QEVPIIIVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QEVPIIIVFR 10 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 2009750.0 692880.0 475070.0 841800.0 False True 670884.9036633376 664767.9284573222 621307.3265413187 1.0 0.9908822285721233 0.9261012181801934 19.355705754786406 -6.932375712339335 0.7270560326997851 1.0009035460311868 0.9119613300112313 0.9969843921589319 0.001806591693603436 0.09142331473563062 0.07178118682412996 0.0016697781466753915 0.005786916513032105 1.1684880833413886e-07 6.932375712339335 -0.08894221601995556 QEVPIIIVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QEVPIIIVFR 10 0 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 0 3688020.0 791120.0 1604200.0 1292700.0 False True 1083618.443214125 1533321.1396200026 987390.8839922007 1.0 1.4150009620286756 0.9111979315002213 20.04742542289287 -6.687848073467378 1.8738157155171085 1.2606958962915482 0.912970306488681 0.360506313498575 0.17559262176440804 0.42129744119024315 2.8662384097084432 0.07500882155317423 0.19587744153346004 2.051879849632132e-07 6.687848073467378 -0.34772558980286716 QEVQDLQASLK(ub)EEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QEVQDLQASLKEEK 14 1 Q15075 Q15075 EEA1 Early endosome antigen 1 1 18132600.0 5697400.0 9073800.0 3361400.0 True False 8643372.335732743 7454509.496077018 2697017.8166460395 1.0 0.8624538208610055 0.3120330481999766 23.04316287972107 -6.944865098945601 0.6126355226148286 1.0060669227428893 0.13962597082744818 0.9987341574533759 0.010575511629514384 0.08561563533547638 0.0450180433960227 0.010723111508483426 0.04645629399231354 1.1353634288066744e-07 6.944865098945601 -0.8664409519154411 down QEVQDLQASLK(ub)EEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QEVQDLQASLKEEK 14 1 Q15075 Q15075 EEA1 Early endosome antigen 1 1 6816400.0 3100000.0 2202700.0 1513700.0 True False 2577787.353285362 2190833.617898285 1830207.6714419709 1.0 0.8498891947414092 0.7099917179395698 21.297701827199866 -6.971973446293902 0.20566011223733643 1.0774243083566633 0.4785700504122942 0.9999939562829564 0.00029106579462105794 0.07566741033760328 0.0066874335788887984 0.00433732542693523 0.01464592472035143 1.0666613372230078e-07 6.971973446293902 -0.598854257944369 QEYDESGPSIVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QEYDESGPSIVHR 13 0 P60709;A0A2R8YFE2;Q9BYX7;P63261;Q6S8J3;A5A3E0;P0CG38;P0CG39 P60709;P63261;Q6S8J3 ACTB;POTEKP;ACTG1;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 283298900.0 5438000.0 150586100.0 127274800.0 False True 7129270.6616669195 128119240.8600203 114105624.60209 1.0 17.97087625651518 16.005231112295935 22.76532306301772 -9.838566957969038 7.867188844645412 0.9999999883431996 16.988053684405564 0.9887905421791388 0.8024712697861219 1.694594890744246e-07 2.354700362179533e-08 0.7769894659228451 0.2589964886409608 1.4502171677748845e-10 9.838566957969038 15.988053696062364 QEYDESGPSIVHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QEYDESGPSIVHR 13 0 P60709;A0A2R8YFE2;Q9BYX7;P63261;Q6S8J3;A5A3E0;P0CG38;P0CG39 P60709;P63261;Q6S8J3 ACTB;POTEKP;ACTG1;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 308919800.0 77887800.0 24952000.0 206080000.0 False True 75415294.42262617 34915463.722961016 152101465.73251954 1.0 0.46297589885806567 2.0168517128653667 26.168353799775574 -6.813390397732293 1.4003144127486569 0.7084803087557336 2.046174837839575 0.8684776281440433 0.23368724913071662 0.20221336394149245 0.780841752715475 0.13119855163343275 0.30303869379019116 1.5367725774609223e-07 6.813390397732293 1.3376945290838416 up QEYDESGPSIVHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QEYDESGPSIVHR 13 0 P60709;A0A2R8YFE2;Q9BYX7;P63261;Q6S8J3;A5A3E0;P0CG38;P0CG39 P60709;P63261;Q6S8J3 ACTB;POTEKP;ACTG1;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 1252745600.0 6465700.0 1240691000.0 5588900.0 False True 9808939.60598644 1019279997.4869711 4484251.465298104 1.0 103.91337274264589 0.45715965694817257 23.225665751857115 -13.949171386074797 4.0075559793177693e-16 9.068140431165656 85.06533872842992 0.0 50.08704801991842 0.0 0.24384091994835227 71.32567842914824 71.32568124207906 1.1241612575157542e-14 13.949171386074797 75.99719829726426 QEYDESGPSIVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QEYDESGPSIVHR 13 0 P60709;A0A2R8YFE2;Q9BYX7;P63261;Q6S8J3;A5A3E0;P0CG38;P0CG39 P60709;P63261;Q6S8J3 ACTB;POTEKP;ACTG1;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 241639500.0 5438000.0 112554000.0 123647500.0 False True 7448575.55642433 107580992.11369511 94444507.10019788 1.0 14.443163165728711 12.679539381021696 22.828533124540613 -9.427250801327043 9.559584061099576 1.0000005711738225 13.561351273375235 0.9854311020307052 0.7199963951282391 0.0 0.0 0.6971335742437381 0.23237783730505823 3.738946049960619e-10 9.427250801327043 12.561350702201413 QEYDESGPSIVHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QEYDESGPSIVHR 13 0 P60709;A0A2R8YFE2;Q9BYX7;P63261;Q6S8J3;A5A3E0;P0CG38;P0CG39 P60709;P63261;Q6S8J3 ACTB;POTEKP;ACTG1;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 82587900.0 77887800.0 2849500.0 1850600.0 False True 64767156.71458702 2834149.1779185366 2237551.9037923724 1.0 0.043759048902022014 0.03454763212244618 25.94875907520985 QEYDESGPSIVHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QEYDESGPSIVHR 13 0 P60709;A0A2R8YFE2;Q9BYX7;P63261;Q6S8J3;A5A3E0;P0CG38;P0CG39 P60709;P63261;Q6S8J3 ACTB;POTEKP;ACTG1;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 28490300.0 6465700.0 13277000.0 8747600.0 False True 8369976.108001174 12538123.278579006 7155626.557955631 1.0 1.4979879412789892 0.8549160075995078 22.996792073949564 -6.699961356870891 1.8309298158379268 1.3092461841135898 0.8568285469528869 0.4173728992351755 0.21020922813951007 0.3956342939124277 2.5784481386269285 0.09159223356906444 0.2355690709250848 1.9954398594987866e-07 6.699961356870891 -0.45241763716070293 QEYEEGGK(ub)QCVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 QEYEEGGKQCVER 13 1 O96019;O96019-2;O94805 O96019 ACTL6A;ACTL6B Actin-like protein 6A;Actin-like protein 6B 1 18096700.0 4470000.0 5445500.0 8181200.0 True False 5860213.287541575 4633052.626392748 7334687.903611863 1.0 0.7905945396633107 1.2516076708683834 22.48252174306364 -6.783248698513063 1.5235678368946315 0.8819276229407947 1.2556148221097487 0.7785915622864658 0.08868301963523047 0.2455661177449887 1.1261292214787493 0.045839431609349106 0.10785573841417136 1.6472188423617527e-07 6.783248698513063 0.373687199168954 QEYEEGGK(ub)QCVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 QEYEEGGKQCVER 13 1 O96019;O96019-2;O94805 O96019 ACTL6A;ACTL6B Actin-like protein 6A;Actin-like protein 6B 1 10890500.0 4240200.0 3001100.0 3649200.0 True False 4105597.1719681364 4199454.880529754 2693365.0463466193 1.0 1.022860915143466 0.6560227254481172 21.969160651102484 -6.89205384317618 1.0101216703401827 1.0187510847165002 0.6231678698426452 0.9821817278686128 0.02239887361606412 0.11749381571246674 0.21222495790579574 0.016848141656711432 0.042326807661627726 1.2821716110952379e-07 6.89205384317618 -0.39558321487385506 QEYEEGGK(ub)QCVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 QEYEEGGKQCVER 13 1 O96019;O96019-2;O94805 O96019 ACTL6A;ACTL6B Actin-like protein 6A;Actin-like protein 6B 1 79188100.0 9167100.0 17748000.0 52273000.0 True False 13907160.904780373 14580730.734243063 41941218.637930155 1.0 1.0484333095787481 3.0158001999900286 23.72932459331873 -6.912192090591924 0.8806583624020421 0.9432276431478624 3.282355452770598 0.9917231785872961 0.08543195806833707 0.10298667678888646 0.1310307237058032 0.07071131119155043 0.1982952469343907 1.2240746652489193e-07 6.912192090591924 2.3391278096227355 up QEYEEGGK(ub)QCVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QEYEEGGKQCVER 13 1 O96019;O96019-2;O94805 O96019 ACTL6A;ACTL6B Actin-like protein 6A;Actin-like protein 6B 1 19807500.0 4470000.0 4189500.0 11148000.0 True False 6122679.797207927 4004394.0371761676 8515072.000266928 1.0 0.6540263691402345 1.3907426620856413 22.54573180458653 -6.779000605955614 1.5396721420646535 0.8038436234334634 1.3964047569865479 0.7638444243816019 0.14624831796997315 0.252143897982362 1.180550980110266 0.07481701838906765 0.1766916053753069 1.6634103294713967e-07 6.779000605955614 0.5925611335530845 QEYEEGGK(ub)QCVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QEYEEGGKQCVER 13 1 O96019;O96019-2;O94805 O96019 ACTL6A;ACTL6B Actin-like protein 6A;Actin-like protein 6B 1 78250100.0 9167100.0 12684000.0 56399000.0 True False 11866991.660556119 11978124.249867894 46134960.70260864 1.0 1.0093648493645748 3.887671115161686 23.50045091541118 -6.907611121196625 0.9118289370526946 0.9040096375280818 4.241270055924629 0.9899889011372706 0.13598132698636628 0.10601957598503357 0.14748524003855734 0.11003112237541335 0.2989434925566062 1.2370546292053168e-07 6.907611121196625 3.337260418396547 up QFAALVASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFAALVASK 9 0 Q99460;A0A087WW66;Q99460-2;C9J9M4 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 7388400.0 1943700.0 2368700.0 3076000.0 False True 2548209.522817577 2015299.193120285 2757725.0270754998 1.0 0.7908687158864204 1.0822206739209812 21.281052475294512 -6.714068621468264 1.780770165514164 0.8719661957299131 1.0816189145127462 0.48433316579501706 0.08807323786377169 0.3669752266392954 2.2709217944709366 0.03932228113931298 0.09940477791597042 1.9316630770592602e-07 6.714068621468264 0.2096527187828331 QFAALVASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFAALVASK 9 0 Q99460;A0A087WW66;Q99460-2;C9J9M4 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 2419550.0 771150.0 443700.0 1204700.0 False True 746670.2653561693 620871.7238649324 889152.9297746827 1.0 0.8315206225183888 1.1908240772793433 19.510111754188113 -6.779210753143079 1.5390815541665566 0.9045044944763555 1.1935932901529867 0.7645392037334636 0.07122374853131717 0.2518043567533613 1.1781079453797012 0.03645162253752504 0.08606256903637563 1.6626056302236703e-07 6.779210753143079 0.28908879567663115 QFAEILHFTLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFAEILHFTLR 11 0 Q9NUQ9;A0A1W2PRQ0;E5RI16;A0A087X178 Q9NUQ9 FAM49B Protein FAM49B 0 2680100.0 771770.0 993240.0 915090.0 False True 1011797.9438313113 845052.4636191961 820405.2649631075 1.0 0.8351988346796687 0.8108390316119153 19.948489781750226 -13.999999999999982 0.2692207266009106 2.2666899528937443 0.8026918670043609 0.9995816511058495 0.0017185061329711446 14.844902442538102 0.16424438950153783 10.286877953425998 0.010156623940682556 1.0000000000000409e-14 13.999999999999982 -1.4639980858893833 QFAEILHFTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFAEILHFTLR 11 0 Q9NUQ9;A0A1W2PRQ0;E5RI16;A0A087X178 Q9NUQ9 FAM49B Protein FAM49B 0 8548200.0 3977700.0 2107200.0 2463300.0 False True 3851430.0907828943 2948615.948902833 1818087.8325840235 1.0 0.7655898924296602 0.4720552599241011 21.876962807803956 -6.968083652241342 0.3004562656231399 1.0506334783657008 0.1778080531964205 0.9999633375223872 0.001307752099008464 0.07692956438682133 0.01124408758135944 0.004858840659985667 0.02631310021236156 1.0762578887391805e-07 6.968083652241342 -0.8728254251692802 down QFAEILHFTLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFAEILHFTLR 11 0 Q9NUQ9;A0A1W2PRQ0;E5RI16;A0A087X178 Q9NUQ9 FAM49B Protein FAM49B 0 65789000.0 17977000.0 26446000.0 21366000.0 False True 27272423.29474278 21726504.67645888 17143000.734949537 1.0 0.7966473841232521 0.6285836997203743 24.700939561017016 -6.973310862248615 0.16046371585482277 1.169018061416452 0.25175190178982954 0.9999980372222245 0.00021267349111877632 0.07524229178917552 0.004955672764116994 0.0077444032688001934 0.020133388084520497 1.0633815912624153e-07 6.973310862248615 -0.9172661596266225 QFAEILHFTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFAEILHFTLR 11 0 Q9NUQ9;A0A1W2PRQ0;E5RI16;A0A087X178 Q9NUQ9 FAM49B Protein FAM49B 0 4905270.0 771770.0 1763500.0 2370000.0 False True 1057114.2253000364 1685582.7388853494 1810254.8116821514 1.0 1.5945133444845445 1.7124495805250888 20.011699843273117 -11.438763951386111 0.28387585289787165 1.332870927215906e-18 1.7516274351397478 0.9993301369270022 0.008069760750781271 3.784845702659369 0.1529321088412618 2.3806868139625696 0.04567918148577765 3.6411288572552815e-12 11.438763951386111 1.7516274351397478 QFAEILHFTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QFAEILHFTLR 11 0 Q9NUQ9;A0A1W2PRQ0;E5RI16;A0A087X178 Q9NUQ9 FAM49B Protein FAM49B 0 8402200.0 3977700.0 1903600.0 2520900.0 False True 3307633.7919881237 1893344.928964982 3048008.5346753434 1.0 0.5724167329379432 0.9215072545389836 21.657368083238232 -9.958016764480364 6.785815435472219 1.0000000215020481 0.7469619937384621 0.41195216579342053 0.14251560866076837 4.6253374852186154e-08 7.272395019602971e-09 0.13799015706670542 0.045996714909813316 1.1014967891353863e-10 9.958016764480364 -0.2530380277635861 QFAEILHFTLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFAEILHFTLR 11 0 Q9NUQ9;A0A1W2PRQ0;E5RI16;A0A087X178 Q9NUQ9 FAM49B Protein FAM49B 0 52850000.0 17977000.0 20144000.0 14729000.0 False True 23271580.87964756 19022968.692000866 12048473.132302413 1.0 0.8174334520022931 0.5177333329700669 24.472065883109465 -6.96371499971226 0.3794621348132659 1.020711407939848 0.3038662856537076 0.9998841536530645 0.0021398321492313286 0.07839978623798954 0.01641449757663428 0.00390249081916714 0.025330927414633077 1.0871388107433079e-07 6.96371499971226 -0.7168451222861405 QFAEMYVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFAEMYVAK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 32369800.0 7399800.0 13221000.0 11749000.0 False True 9701209.459765142 11248478.335054364 10533326.184366075 1.0 1.1594923686274763 1.0857745344074943 23.209733190111848 -10.024605071055987 4.99974529297357 0.9999983711438949 1.1226334515185743 0.7867746370176403 0.030095179800782117 5.464729065299169e-07 1.0656409632703184e-07 0.029139919419219045 0.009713177513588663 9.449197555785237e-11 10.024605071055987 0.1226350803746794 QFAEMYVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFAEMYVAK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 22986900.0 4546900.0 2979000.0 15461000.0 False True 4402561.148347227 4168530.235279776 11411300.279942185 1.0 0.9468420982283667 2.591968605416445 22.069911611496423 -6.899433782528055 0.9648543016722042 0.9305349538188817 2.762671959323217 0.9862820991969244 0.08940022992232168 0.11182278908470457 0.17978579899041786 0.06956743785807884 0.18049115280766861 1.260567823737877e-07 6.899433782528055 1.8321370055043351 up QFAEMYVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFAEMYVAK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 29307800.0 7399800.0 8545000.0 13363000.0 False True 10135706.032075897 8167453.645463732 10206934.619623885 1.0 0.8058100362832794 1.0070274914566952 23.27294325163474 -11.073789070352012 10.126360952693842 1.5228818230994279 0.9064187638655271 0.22383941813858654 0.082146682086036 0.04435946914080458 0.00032324034159048466 0.003638432217804126 0.026512727638784376 8.43744450992562e-12 11.073789070352012 -0.6164630592339008 QFAEMYVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QFAEMYVAK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 12010500.0 4546900.0 5118900.0 2344700.0 False True 3780948.8118236214 5091323.469677898 2834965.929332089 1.0 1.3465729696621465 0.7498027797855145 21.8503168869307 -6.749239540554244 1.652623518212424 1.2039650143058995 0.7486792298899193 0.6457933677283486 0.1456261856314074 0.30132940056329854 1.6189727387788742 0.06961680158147068 0.16914830115513108 1.7813959452113333e-07 6.749239540554244 -0.4552857844159802 QFAEMYVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFAEMYVAK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 20025500.0 4731300.0 9929500.0 5364700.0 False True 6124761.117865967 9376914.596268 4388379.646470412 1.0 1.530984542224101 0.7164980906225845 22.54622214555516 -6.73077617397364 1.7204492447617936 1.3192637031763856 0.7169154775846449 0.5628762456910595 0.22319908889948017 0.3347659406606791 1.9416053651556884 0.10279490349632249 0.25484995198319316 1.8587621742852496e-07 6.73077617397364 -0.6023482255917407 QFAEWICHLHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFAEWICHLHK 11 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 3719500.0 0.0 1645600.0 2073900.0 False True 0.0 1400082.89449856 1859312.7222535368 0.0 QFAIVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFAIVFK 7 0 P19838;P19838-2;P19838-3;A0A494C1E9;D6RF93 P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit;Nuclear factor NF-kappa-B p50 subunit 0 6320900.0 1671900.0 2157700.0 2491300.0 False True 2191877.090702632 1835779.5706487242 2233524.1742370613 1.0 0.8375376422499327 1.0190006473041235 21.06373547090486 -6.670655985901533 1.9348189279169505 0.8963616873024735 1.0182732535003565 0.2820750342971069 0.06899962663362069 0.4595999887089834 3.3175688786011572 0.028702021282740568 0.07662547163627788 2.134735213757363e-07 6.670655985901533 0.12191156619788301 QFAIVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFAIVFK 7 0 P19838;P19838-2;P19838-3;A0A494C1E9;D6RF93 P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit;Nuclear factor NF-kappa-B p50 subunit 0 4990100.0 1671900.0 1678000.0 1640200.0 False True 2290046.6113986443 1603860.4115960381 1252818.5409793528 1.0 0.700361470204522 0.5470711970417906 21.12694553242775 -13.99999999999975 0.08586206822337433 2.5642467227793264 0.13510998379546263 0.999861397707868 0.0022144531797115632 12.201793823041324 0.08409917842263451 3.5366801616508714 0.37163137579847233 1.0000000000005767e-14 13.99999999999975 -2.4291367389838636 QFAK(ub)FVVDLSDQVAPTDIEEGMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFAKFVVDLSDQVAPTDIEEGMR 23 1 P35998 P35998 PSMC2 26S protease regulatory subunit 7 1 68264000.0 20656000.0 25563000.0 22045000.0 True False 26739599.190632436 24140396.57831702 18033036.200801574 1.0 0.902795752704252 0.6743944092893885 24.672474504735522 -6.956776363403753 0.4787096860338547 1.0055494043713882 0.562138878153645 0.9996313164641512 0.0026205153368999254 0.08087343886090945 0.025543872091487632 0.0032120113078542498 0.01884208108094161 1.1046473030849447e-07 6.956776363403753 -0.44341052621774313 QFAPIHAEAPEFMEMSVEQEILVTGIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFAPIHAEAPEFMEMSVEQEILVTGIK 27 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 84903000.0 9277000.0 55569000.0 20057000.0 False True 14073887.239546584 45652277.78742137 16092725.158704625 1.0 3.243757535525923 1.143445651140735 23.746517523465453 -6.630502519508958 2.0779505283034725 2.4776027782434453 1.151791332112714 0.11957503252682344 0.9623118738870495 0.5576677396855128 4.58913989728491 0.3786217049191097 1.0664272480478714 2.341517891086012e-07 6.630502519508958 -1.3258114461307313 QFAPIHAEAPEFMEMSVEQEILVTGIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFAPIHAEAPEFMEMSVEQEILVTGIK 27 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 24748400.0 9277000.0 5441400.0 10030000.0 False True 12009259.377008986 5138581.306624979 8204642.916490797 1.0 0.4278849465490343 0.6831930811818503 23.517643845557902 -10.382635631416179 5.958991241386722 1.0000931032369234 0.5555390138654496 0.8016222201096594 0.10422910950536604 0.00012894911661353505 1.3359501505112175e-05 0.10094037517530872 0.03363980044202583 4.143471620187671e-11 10.382635631416179 -0.4445540893714738 QFASQANVVGPWIQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFASQANVVGPWIQTK 16 0 O43707;O43707-2;O43707-3;F5GXS2;H7C144 O43707 ACTN4 Alpha-actinin-4 0 12904500.0 4202800.0 5026700.0 3675000.0 False True 5509911.499973099 4276735.953923134 3294746.2530892296 1.0 0.7761895910567737 0.5979671820691341 22.39359771578389 -6.973697786069737 0.14474892512879614 1.2230810833337369 0.14640887324436797 0.9999987544868781 0.0001834737054316524 0.07511993957596738 0.004402553623113543 0.009591125977159325 0.02272810379396044 1.0624346198970266e-07 6.973697786069737 -1.0766722100893689 QFASQANVVGPWIQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFASQANVVGPWIQTK 16 0 O43707;O43707-2;O43707-3;F5GXS2;H7C144 O43707 ACTN4 Alpha-actinin-4 0 10600100.0 3174900.0 1150500.0 6274700.0 False True 3074114.537352392 1609900.6497782401 4631167.833034942 1.0 0.523695727734589 1.5065046460577152 21.5517394882214 -6.7748977518727145 1.555470570329724 0.7285205319320646 1.5131187078217556 0.7490294431206459 0.20103570018134254 0.2585771060350525 1.235258317204865 0.10182965539114565 0.24134791945564116 1.6791993139009308e-07 6.7748977518727145 0.784598175889691 QFASQANVVGPWIQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFASQANVVGPWIQTK 16 0 O43707;O43707-2;O43707-3;F5GXS2;H7C144 O43707 ACTN4 Alpha-actinin-4 0 10520100.0 4202800.0 3044600.0 3272700.0 False True 5756688.73639944 2910079.5048541757 2499755.6633722237 1.0 0.5055127414573929 0.43423498782664993 22.456807777306782 -13.999999999999998 0.2728114438326521 4.874905414931336 0.41121255892598435 0.9995894038891511 0.005098054814433576 15.022785526547045 0.16536987779789428 32.339660545959205 0.02919310247089541 1.0000000000000041e-14 13.999999999999998 -4.463692856005351 QFASQANVVGPWIQTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QFASQANVVGPWIQTK 16 0 O43707;O43707-2;O43707-3;F5GXS2;H7C144 O43707 ACTN4 Alpha-actinin-4 0 7011300.0 3174900.0 1981800.0 1854600.0 False True 2640070.021917966 1971123.6500435004 2242388.285298457 1.0 0.7466179433420908 0.849366973861322 21.332144763655677 -10.160205833840301 4.647799248488385 1.000025244838527 0.797992458599509 0.837495919306952 0.04194711606381417 10165899.225569488 22222911.911681674 1661.7083720646406 0.014359614050448354 6.915031553673143e-11 10.160205833840301 -0.202032786239018 QFAYQNSWGLTTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFAYQNSWGLTTR 13 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 31895200.0 12063000.0 10990000.0 8842200.0 False True 15814709.81825819 9350334.838684473 7927293.964371585 1.0 0.5912428964007577 0.5012607917231254 23.914763748514478 -13.999999999999996 0.21268764179138178 3.3904941271552853 0.4496219481315803 0.9994916901006105 0.004893106325891105 12.810924275477555 0.1461551426553499 12.814251548963995 0.05231467381415224 1.0000000000000082e-14 13.999999999999996 -2.940872179023705 QFAYQNSWGLTTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFAYQNSWGLTTR 13 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 28591900.0 11071000.0 3979900.0 13541000.0 False True 10719557.16495902 5569094.82490432 9994205.878707534 1.0 0.519526575510884 0.9323338385075667 23.353741972142142 -10.160788152280057 7.703958801250158 1.0000000938874776 0.7259302070092256 0.3701638501985176 0.16852785940946202 2.7184959279186187e-07 2.9668231208218078e-08 0.16317645414067453 0.05439213273873594 6.905765831566205e-11 10.160788152280057 -0.27406988687825196 QFAYQNSWGLTTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFAYQNSWGLTTR 13 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 31986400.0 9213400.0 22773000.0 0.0 False True 13977401.389763761 18708980.22373888 0.0 1.0 1.3385163452085058 0.0 23.73659283103522 -6.872563132914813 1.3559142797628645 1.1773822733496817 5.537611950531187e-20 0.9228537124411689 0.15783396032090957 0.1547718485255359 0.5721085993466926 0.0942131157155864 0.19365735377252236 1.341024977897992e-07 6.872563132914813 -1.1773822733496817 down QFAYQNSWGLTTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFAYQNSWGLTTR 13 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 36702000.0 12063000.0 10498000.0 14141000.0 False True 16523017.090317521 10034163.647756396 10801187.04303684 1.0 0.6072839840876525 0.6537054936151055 23.97797381003737 -10.730820767772434 10.495193756340845 1.0005527546806232 0.6304947390001077 0.988301024971237 0.01895150190533464 0.0002454372042848916 6.294924414769794e-06 0.018373884118674667 0.006116570938748268 1.8585713244945467e-11 10.730820767772434 -0.37005801568051555 QFAYQNSWGLTTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QFAYQNSWGLTTR 13 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 21499300.0 11071000.0 5254300.0 5174000.0 False True 9206027.028458804 5225994.043003108 6255859.47812695 1.0 0.5676709428342837 0.6795395515120765 23.13414724757642 -10.091115359329839 7.450731474356267 1.000000063648499 0.6236052471731864 0.9378657179966663 0.04567016824927983 4.832045930821163e-08 5.925355301807149e-09 0.04421995751014976 0.01473998342066262 8.107456751945906e-11 10.091115359329839 -0.3763948164753125 QFAYQNSWGLTTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFAYQNSWGLTTR 13 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 39297400.0 9213400.0 30084000.0 0.0 False True 11926927.923265552 28409798.954038657 0.0 1.0 2.3819879802090855 0.0 23.50771915312767 -6.751419953306026 1.6576212645175126 1.8131289299943156 1.1077659164260688e-09 0.6463311553887139 0.580785636747208 0.29950070600207995 1.6218240282006267 0.27736558333474154 0.668947866191858 1.7724747075079453e-07 6.751419953306026 -1.8131289288865498 QFCFNCGENWHDPVK(ub)CK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFCFNCGENWHDPVKCK 17 1 Q9Y4X5 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 987150000.0 222869000.0 438207000.0 326074000.0 True False 292183417.2664664 372828223.7175073 292334990.4026711 1.0 1.2760074723114563 1.0005187602281567 28.122299060079758 -10.406130508460661 3.742664748414288 0.9991728604244049 1.138263116287032 0.2514122845341856 0.11246779580737819 80660189.95814145 651.5607224254156 575578.6700162969 0.03850059055272167 3.925269606393792e-11 10.406130508460661 0.13909025586262713 QFCFNCGENWHDPVK(ub)CK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFCFNCGENWHDPVKCK 17 1 Q9Y4X5 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 109233680.0 91145800.0 14358480.0 3729400.0 True False 88252426.46968853 20091895.942484017 2752558.2603981923 1.0 0.22766394926699093 0.031189604303328646 26.395132609537693 -9.932822355334475 0.3554304269543861 1.4172026693311293 2.208587986052257e-17 0.9985876670305001 0.015714771167557325 1.3644750374618486 0.16649034198800436 0.6596684642360983 0.057132043596156416 1.1672869887780172e-10 9.932822355334475 -1.4172026693311293 QFCFNCGENWHDPVK(ub)CK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFCFNCGENWHDPVKCK 17 1 Q9Y4X5 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 1954878000.0 714530000.0 627531000.0 612817000.0 True False 1083994249.1401532 515543190.12791777 491693451.3427667 1.0 0.475595871967824 0.45359415119848484 30.01370995684134 QFCFNCGENWHDPVK(ub)CK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFCFNCGENWHDPVKCK 17 1 Q9Y4X5 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 948297000.0 222869000.0 350781000.0 374647000.0 True False 305269692.1082629 335282335.5423545 286163094.6971656 1.0 1.0983151757608736 0.9374107620080372 28.18550912160265 -6.741378613056544 1.6820208811941793 1.0584043476795488 0.9372945897288903 0.6109781641208265 0.041306523314718374 0.31531737465734927 1.7522196734980284 0.019424984763357935 0.04758837508228955 1.8139336062981354e-07 6.741378613056544 -0.12110975795065848 QFCFNCGENWHDPVK(ub)CK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QFCFNCGENWHDPVKCK 17 1 Q9Y4X5 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 244608900.0 91145800.0 3069100.0 150394000.0 True False 75791771.14357333 3052566.149131347 181840690.05671138 1.0 0.040275693562416316 2.399214153634808 26.17553788497197 -6.796259678070397 1.4712300838826025 0.46794394474270057 2.428813600289468 0.820974448885066 0.40982318342503565 0.2261412066959227 0.9667234607022105 0.2191870224298931 0.5109320639487163 1.598601889397854e-07 6.796259678070397 1.9608696555467673 QFCFNCGENWHDPVK(ub)CK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFCFNCGENWHDPVKCK 17 1 Q9Y4X5 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 1475039000.0 714530000.0 402688000.0 357821000.0 True False 924973170.4919925 380278058.8087986 292701249.5535055 1.0 0.4111233395088952 0.31644296168916763 29.78483627893379 -13.999999999999998 0.2572306797985361 5.249335583514986 0.2809088831122904 0.9995567356559 0.006366596548107082 14.296438673812025 0.16048939369114062 31.526308497428115 0.04200566272394496 1.0000000000000041e-14 13.999999999999998 -4.968426700402696 QFEQAK(ub)DACLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFEQAKDACLR 11 1 Q99747;J3KTJ6 Q99747 NAPG Gamma-soluble NSF attachment protein 1 6551300.0 2841500.0 1639900.0 2069900.0 True False 2751298.137858465 2294720.6219655233 1527731.0943310477 1.0 0.8340501490513388 0.5552764614307455 21.391681051655322 -6.963307116377104 0.3860064448784064 1.0179017729629831 0.3614719987838432 0.9998738812320132 0.002060686705514629 0.07854022271847254 0.0169153492386889 0.003608694047268657 0.02349074430396166 1.0881603160059041e-07 6.963307116377104 -0.65642977417914 QFEQAK(ub)DACLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFEQAKDACLR 11 1 Q99747;J3KTJ6 Q99747 NAPG Gamma-soluble NSF attachment protein 1 10497600.0 3400700.0 3447800.0 3649100.0 True False 5159110.524471918 2832513.152215647 2927853.7855426525 1.0 0.5490312988604912 0.5675113513568979 22.29869092323859 -10.371140673900973 9.00971503913271 1.0000009534814909 0.5582713251187624 0.9986890473043194 0.007544449839340487 1.4449338838436394e-07 1.0088128562167376e-08 0.007304897817740865 0.0024349607153385812 4.2546057833243946e-11 10.371140673900973 -0.44172962836272844 QFESK(ub)IIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFESKIIK 8 1 Q9UHC7-2;Q9UHC7;Q9UHC7-3;Q9UHC7-4 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 8031970.0 3610200.0 3649700.0 772070.0 True False 4733007.161226533 3105178.9864191716 692183.6026183941 1.0 0.6560689389733526 0.14624605014098868 22.174325674256607 -7.423860196142552 0.48550475610056204 1.0153027996418906 4.543838814073028e-27 0.9979647305773193 0.015822818018054276 0.1119832792086964 0.058337684691375985 0.018390290680447334 0.06401592514417706 3.768250833288931e-08 7.423860196142552 -1.0153027996418906 down QFESK(ub)IIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFESKIIK 8 1 Q9UHC7-2;Q9UHC7;Q9UHC7-3;Q9UHC7-4 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 11922000.0 4068100.0 4402400.0 3451500.0 True False 3938960.39226536 6160301.278212716 2547448.607219489 1.0 1.5639409043841201 0.6467312065949488 21.90938347950547 -6.740367693963218 1.6855752763431993 1.335400482518797 0.6461731023352791 0.6065196228314201 0.2369408894441418 0.31713980783359286 1.7693929692840236 0.11120378693162172 0.2727502951129035 1.8181608670013323e-07 6.740367693963218 -0.6892273801835179 QFESK(ub)IIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFESKIIK 8 1 Q9UHC7-2;Q9UHC7;Q9UHC7-3;Q9UHC7-4 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 15497900.0 4695000.0 5416000.0 5386900.0 True False 7122658.250476566 4449472.484598856 4322176.853837853 1.0 0.6246926818791494 0.6068207545334163 22.76398433987702 QFESK(ub)IIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFESKIIK 8 1 Q9UHC7-2;Q9UHC7;Q9UHC7-3;Q9UHC7-4 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 6456500.0 3610200.0 1842900.0 1003400.0 True False 4944988.501986593 1761474.584344662 766417.5856716754 1.0 0.35621409102104273 0.15498874979462052 22.2375357357795 -12.439081350944859 0.1879451725900032 2.8633653165911044 6.978182028003121e-20 0.9994408523667763 0.008522134692634372 6.513196085862244 0.12578608195685034 4.733448125983241 0.13863919338532374 3.638468748663744e-13 12.439081350944859 -2.8633653165911044 QFESK(ub)IIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QFESKIIK 8 1 Q9UHC7-2;Q9UHC7;Q9UHC7-3;Q9UHC7-4 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 14338200.0 4068100.0 8680800.0 1589300.0 True False 3382805.3973871614 8634034.807396103 1921615.281907067 1.0 2.5523297361606816 0.5680537471624291 21.689788754939745 -6.69797763844969 1.837901746222513 1.9658095654524763 0.5741275865523823 0.4081254121921556 0.6554985527637361 0.3997105906787271 2.623458552652773 0.2846761822261345 0.7339941560182146 2.0045752390289712e-07 6.69797763844969 -1.391681978900094 QFESK(ub)IIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFESKIIK 8 1 Q9UHC7-2;Q9UHC7;Q9UHC7-3;Q9UHC7-4 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 20403900.0 4695000.0 10810000.0 4898900.0 True False 6077770.052285987 10208413.997246288 4007350.466958807 1.0 1.6796314946806308 0.6593455218746803 22.53511066196947 -6.727160872911984 1.7334851292489888 1.4103002107488587 0.6602592953739803 0.5459988902852333 0.2857728442832602 0.3416381871008674 2.009868408046152 0.13070829797921943 0.3254035427905911 1.8743000945313934e-07 6.727160872911984 -0.7500409153748784 QFFLQFHFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFFLQFHFK 9 0 Q15428 Q15428 SF3A2 Splicing factor 3A subunit 2 0 21760600.0 4859500.0 13560000.0 3341100.0 False True 6370851.55946494 11536900.856466006 2995395.0220942614 1.0 1.8108883480931302 0.47017184345538754 22.603054792434797 -6.742947154537646 1.6758200481474552 1.480810799730943 0.46885309121447993 0.6181686646204829 0.34068655696786043 0.31249317645955244 1.724236528606219 0.16075277332126978 0.39321709814796607 1.8073940384592608e-07 6.742947154537646 -1.011957708516463 QFFLQFHFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFFLQFHFK 9 0 Q15428 Q15428 SF3A2 Splicing factor 3A subunit 2 0 51941800.0 28033000.0 14608000.0 9300800.0 False True 27143107.759488404 20441050.57971363 6864641.46198088 1.0 0.7530843837352436 0.2529055081977933 24.694082576291798 -7.020002240519668 0.4549130793279129 1.01563778245891 4.1549057134052935e-15 0.9997425179460789 0.004986959938721433 0.07390355661606512 0.022404797313532857 0.006671389903023507 0.03818657212547556 9.549876592396284e-08 7.020002240519668 -1.0156377824589058 down QFFLQFHFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFFLQFHFK 9 0 Q15428 Q15428 SF3A2 Splicing factor 3A subunit 2 0 1269160000.0 330120000.0 407480000.0 531560000.0 False True 500816175.0047547 334762010.3442289 426496933.0089752 1.0 0.6684329042308802 0.8516037506275154 28.89970591726061 -10.112686078041843 5.062187882790681 1.0000077344250937 0.7600183286072125 0.6959252234453402 0.07477918490622348 6.527764991351552e-06 1.1441651319953571e-06 0.07240696704971933 0.024134878148447142 7.714609042188543e-11 10.112686078041843 -0.2399894058178812 QFFLQFHFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFFLQFHFK 9 0 Q15428 Q15428 SF3A2 Splicing factor 3A subunit 2 0 28318900.0 4859500.0 8040400.0 15419000.0 False True 6656188.473049647 7685148.541952802 11777349.764273046 1.0 1.1545869791802514 1.7693834560061743 22.66626485395769 -6.945007818165231 0.6112096283002915 0.9932110915987469 1.9628420610397552 0.9987488922637945 0.011753860001166787 0.08555463583573218 0.044752799535619475 0.011933899511317025 0.05186324063574254 1.1349903834020605e-07 6.945007818165231 0.9696309694410084 QFFLQFHFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QFFLQFHFK 9 0 Q15428 Q15428 SF3A2 Splicing factor 3A subunit 2 0 68874000.0 28033000.0 19083000.0 21758000.0 False True 23310681.572467305 18980196.091321055 26307497.202374544 1.0 0.8142274189759827 1.1285597600649668 24.474487851726074 -6.746582024030221 1.6626769221386175 0.8903169182987992 1.1290188522250384 0.6340842435523915 0.07805285824888158 0.3060315121797246 1.6634770437583088 0.03710267702218011 0.09039445499924391 1.792330007850662e-07 6.746582024030221 0.23870193392623917 QFFLQFHFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFFLQFHFK 9 0 Q15428 Q15428 SF3A2 Splicing factor 3A subunit 2 0 1142940000.0 330120000.0 431060000.0 381760000.0 False True 427346847.63805103 407071132.06780624 312283597.18838763 1.0 0.9525544281365154 0.7307497385657136 28.67083223935306 -6.941315473933792 0.6472112556412299 1.002444175081429 0.6685483310403629 0.9983311529531025 0.004794017748904919 0.08717165551536288 0.05191528510326426 0.0047145060123798006 0.01898238202421059 1.1446811366065534e-07 6.941315473933792 -0.3338958440410661 QFFVAVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFFVAVER 8 0 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 8563200.0 2349000.0 2622600.0 3591600.0 False True 3079561.747748355 2231318.3028147295 3219975.685059938 1.0 0.7245570914258092 1.0455954284450533 21.554293625005155 -6.679621897039829 1.9033799574873431 0.8256611784973101 1.0443647032752543 0.3222920880053288 0.11674958067148443 0.43938508083364497 3.0773595961398783 0.04922581224983001 0.12988559498052676 2.0911158938573726e-07 6.679621897039829 0.2187035247779442 QFFVAVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFFVAVER 8 0 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 5635290.0 2679900.0 735390.0 2220000.0 False True 2594828.041403095 1029035.0620081886 1638515.401427569 1.0 0.39657158223546907 0.6314543296447417 21.307207504040264 -10.248560834048844 5.56245563697853 1.000032120157567 0.514012955940101 0.8509248295558274 0.09589048008935258 3.819883207511949e-05 5.16042474278649e-06 0.09285167819259112 0.030948519370482413 5.6420790406361175e-11 10.248560834048844 -0.48601916421746605 QFFVAVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFFVAVER 8 0 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 7920400.0 2349000.0 3089600.0 2481800.0 False True 3217488.7793381223 2953091.2560590706 1895649.9542754258 1.0 0.9178248810137446 0.5891706496224004 21.617503686528046 -6.944878834912851 0.612504609689118 1.0036231379070295 0.4861836788257964 0.9987355155498023 0.0063117228741844285 0.08560992425639354 0.044993597740054 0.006400596244077485 0.027737541834615374 1.1353275198349948e-07 6.944878834912851 -0.5174394590812331 QFFVAVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFFVAVER 8 0 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 14200500.0 3136800.0 6009000.0 5054700.0 False True 4060649.4355720337 5674593.867664475 4134796.465601806 1.0 1.3974596816839178 1.0182598944346761 21.95327905105756 -10.832463901480965 9.314914607925624 0.9942827652049366 1.2078597880592965 0.28603559755199237 0.15480766488876346 0.018607017267110337 0.00033466126588015626 0.15173838448802493 0.049963958998286616 1.470740658157886e-11 10.832463901480965 0.21357702285435987 QFGFIVLTTSAGIMDHEEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFGFIVLTTSAGIMDHEEAR 20 0 P62244 P62244 RPS15A 40S ribosomal protein S15a 0 34022300.0 10994300.0 10280000.0 12748000.0 False True 10645291.964475563 14384857.60949178 9408916.368197598 1.0 1.3512882180681878 0.8838570515112335 23.343712182806318 -6.705633506399184 1.8108876870374977 1.2169249806254188 0.8850968485324603 0.44426332942319824 0.14813664648422384 0.38393505934055894 2.45148659254493 0.06516844932262787 0.16643373478652365 1.969547655806532e-07 6.705633506399184 -0.33182813209295847 QFGFIVLTTSAGIMDHEEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFGFIVLTTSAGIMDHEEAR 20 0 P62244 P62244 RPS15A 40S ribosomal protein S15a 0 30299700.0 12123400.0 4290000.0 13886300.0 False True 18392084.13926043 3524415.9820770137 11141666.718418498 1.0 0.19162678657790955 0.6057859802106429 24.13258163537027 -10.617948713070122 5.607940057455632 1.004330777555415 0.39870638343722464 0.7375644496015461 0.16907978278045593 0.009192176446337864 0.0006262328794782049 0.1643739462611625 0.05457026524075603 2.41019003729686e-11 10.617948713070122 -0.6056243941181905 QFGFIVLTTSAGIMDHEEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QFGFIVLTTSAGIMDHEEAR 20 0 P62244 P62244 RPS15A 40S ribosomal protein S15a 0 23422700.0 10994300.0 10264000.0 2164400.0 False True 9142247.580072677 10208705.79475551 2616966.0329451007 1.0 1.1166516445045076 0.2862497443899126 23.124117458240594 -6.871338989563137 1.1270399485663631 1.066534332869793 0.2363745314106458 0.9659987736318177 0.06768421340378143 0.1355748189729865 0.3210492535812214 0.04656984864249282 0.11051539867684315 1.3448102495253234e-07 6.871338989563137 -0.8301598014591471 down QFGFIVLTTSAGIMDHEEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFGFIVLTTSAGIMDHEEAR 20 0 P62244 P62244 RPS15A 40S ribosomal protein S15a 0 27858500.0 9046900.0 11249000.0 7562600.0 False True 11711390.391059889 10622983.261334281 6186284.398828844 1.0 0.907064226075457 0.5282280064330586 23.481409028796197 -6.9444404662118195 0.6168701490529842 1.0041566729439075 0.41117294832068757 0.9986895784781802 0.007386507677558416 0.08579796609362517 0.04581429433367938 0.007460167237739452 0.03202362682835707 1.1364740766896322e-07 6.9444404662118195 -0.5929837246232199 QFIAAQGSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFIAAQGSSR 10 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 6710900.0 1436100.0 2963500.0 2311300.0 False True 1882741.007212184 2521357.3516325247 2072148.8475551393 1.0 1.3391950045035426 1.1006021750295947 20.84440312354652 -10.284501614353282 4.260240291420037 0.9998031990944567 1.2198985897715167 0.5310843912120653 0.09740511476630972 69040956.9206463 43.2160559409781 133285.90819951872 0.03334436160624307 5.193957428129388e-11 10.284501614353282 0.22009539067705997 QFIAAQGSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFIAAQGSSR 10 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 6553700.0 1436100.0 2408600.0 2709000.0 False True 1967064.9791432463 2302180.0878249253 2069189.9936063082 1.0 1.1703630089676236 1.0519174585211426 20.907613185069412 -10.324606812291133 3.749129885173381 0.9996777137141357 1.1111402337448864 0.5400045230741786 0.04835519362814274 5940677.630088318 8179974.5938336635 12586.008381232888 0.016553267273881987 4.735798195508483e-11 10.324606812291133 0.11146252003075063 QFIDSNPNQPLVILEMESGASAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFIDSNPNQPLVILEMESGASAK 23 0 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 2992400.0 1162500.0 1829900.0 0.0 False True 1125597.0738203283 2560588.6128024384 0.0 1.0 2.274871419229692 0.0 20.102259052486747 -6.757498023279522 1.6405819085690028 1.745333168059548 5.316081884623306e-10 0.6685295301699421 0.5359914392299712 0.28984875222504924 1.5401096244036208 0.2586816432304703 0.6186186848987982 1.7478412178167054e-07 6.757498023279522 -1.74533316752794 QFILVMNALDNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFILVMNALDNR 12 0 Q9UBT2;Q9UBT2-2;K7EPL2 Q9UBT2 UBA2 SUMO-activating enzyme subunit 2 0 23322200.0 5958500.0 9189400.0 8174300.0 False True 9039480.124699606 7549479.772890084 6558646.022077029 1.0 0.8351674729901531 0.7255556659896945 23.107808372596846 -8.39039316261105 0.05643127647608738 1.7086112007235288 0.005296750711999178 0.9999981113810393 0.0001549031270011713 0.10765425495871485 0.01259289102375392 0.189831240558864 0.1842177657310661 4.0701164724680065e-09 8.39039316261105 -1.7033144500115296 QFILVMNALDNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFILVMNALDNR 12 0 Q9UBT2;Q9UBT2-2;K7EPL2 Q9UBT2 UBA2 SUMO-activating enzyme subunit 2 0 22457200.0 5958500.0 8145000.0 8353700.0 False True 7713395.709594478 7691723.58996957 6833412.316200324 1.0 0.9971903270050114 0.8859149165263793 22.878934694689296 -6.9123241570422564 0.879750548540597 1.0031972474288098 0.8707955362951167 0.9917696432638128 0.004820052727347593 0.10290131894401462 0.13057625706773868 0.003992160322829538 0.011206089432699351 1.2237024877854877e-07 6.9123241570422564 -0.13240171113369303 QFK(ub)K(ub)AVTDAIMSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFKKAVTDAIMSR 13 2 Q86TM6-2;Q86TM6-3;Q86TM6;E9PMA1 Q86TM6-2 SYVN1 E3 ubiquitin-protein ligase synoviolin 2 3420440.0 508640.0 1205700.0 1706100.0 True False 666831.9656767674 1025814.259781789 1529569.1380668115 1.0 1.5383399605636643 2.293784966523692 19.346963738356212 -6.9663411097397185 0.33423582225692566 0.9123920334735786 2.9446209530500065 0.999938181219947 0.004172294711241568 0.07750876254196691 0.01327112415970086 0.01086291985754414 0.06567146910849231 1.0805848895703633e-07 6.9663411097397185 2.032228919576428 QFK(ub)K(ub)AVTDAIMSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFKKAVTDAIMSR 13 2 Q86TM6-2;Q86TM6-3;Q86TM6;E9PMA1 Q86TM6-2 SYVN1 E3 ubiquitin-protein ligase synoviolin 2 8286500.0 1337700.0 1998000.0 4950800.0 True False 1295235.4457199594 2795811.819432353 3654036.959183611 1.0 2.1585355995861395 2.821137246713092 20.30478294175169 -8.890899139962901 0.19385914191693182 2.3720269295487524e-21 3.5773529357256044 0.9996378846816206 0.014321647560269827 0.3921433168063543 0.0613383853059044 0.6104912545689359 0.3653738870091468 1.2855851880617543e-09 8.890899139962901 3.5773529357256044 QFK(ub)K(ub)AVTDAIMSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QFKKAVTDAIMSR 13 2 Q86TM6-2;Q86TM6-3;Q86TM6;E9PMA1 Q86TM6-2 SYVN1 E3 ubiquitin-protein ligase synoviolin 2 4468300.0 1337700.0 1492500.0 1638100.0 True False 1112356.8201580103 1484459.6062619453 1980619.1362813564 1.0 1.3345174672018263 1.7805609678376488 20.085188217185966 -6.967139797588015 0.3192001824240552 0.9383382838413663 2.19111016476676 0.9999507034439666 0.0022449708445674878 0.07724213761226868 0.012337916856762872 0.006783191387983541 0.03926287942475448 1.0785994696585664e-07 6.967139797588015 1.2527718809253936 QFLDYFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFLDYFK 7 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 12300000.0 2885200.0 3502200.0 5912600.0 False True 3782525.1403165455 2979685.411468678 5300820.869664043 1.0 0.7877503257570733 1.4013973927534655 21.850918240580324 -6.813315673314461 1.4006309253025122 0.8847695816508782 1.4129575198259072 0.8682794320089869 0.0923506947967595 0.20232135853797178 0.7816281278365435 0.05183647911011633 0.11973399565883014 1.5370370162707883e-07 6.813315673314461 0.5281879381750291 QFLDYFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFLDYFK 7 0 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 9103700.0 2885200.0 3234000.0 2984500.0 False True 3951936.4095982816 3091111.186592125 2279622.5677069137 1.0 0.7821763475456174 0.5768368545025854 21.914128302103215 -6.971839476519946 0.20966161041641557 1.1079723826205146 0.24531080561082025 0.9999933938165079 0.0004440519820220288 0.07571033692109229 0.006852275753167952 0.00616552533808682 0.0212948332253709 1.0669904282595801e-07 6.971839476519946 -0.8626615770096944 QFLFRPWDVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFLFRPWDVTK 11 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 84115600.0 24633000.0 25635000.0 33847600.0 False True 32294101.546311293 21810357.92444736 30345375.04110557 1.0 0.6753666112423119 0.9396568905188102 24.944767347800227 -9.95554915644996 6.344106744815782 1.0000000455297102 0.8075117521376537 0.414269320582457 0.10789605470087818 6.942713969748575e-08 1.1532909898548484e-08 0.10446993065200702 0.0348233019148276 1.107773172856826e-10 9.95554915644996 -0.19248829339205653 QFLFRPWDVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFLFRPWDVTK 11 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 58376800.0 27624000.0 8071800.0 22681000.0 False True 26747091.24061314 11294911.833880924 16740165.684585007 1.0 0.42228561349993 0.6258686424625687 24.67287867045738 -10.06957752476097 5.068423169189505 1.000009157179895 0.5240771279794422 0.8793241769426519 0.08311242354774705 8.600180617123257e-06 1.5788346913171907e-06 0.08047480522650495 0.0268244193543776 8.519664155297723e-11 10.06957752476097 -0.47593202920045286 QFLFRPWDVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFLFRPWDVTK 11 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 54000900.0 14593900.0 24487000.0 14920000.0 False True 22140013.25700321 20117103.53219575 11971055.460331695 1.0 0.9086310517827905 0.5406977548464238 24.400152750188592 -6.944720608142651 0.6140771136585796 1.0040485876420837 0.425984834759519 0.9987191214755191 0.00710480224563057 0.08567750858295144 0.045287666290610894 0.007194262347924189 0.03107024923408502 1.1357412297532046e-07 6.944720608142651 -0.5780637528825647 QFLFRPWDVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFLFRPWDVTK 11 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 90332000.0 24633000.0 27785000.0 37914000.0 False True 33740485.781794794 26557366.827291995 28959494.06334057 1.0 0.7871068306201281 0.8583010407919532 25.007977409323118 -10.427214707565453 8.247003827986699 1.0000033491653986 0.8227039357060406 0.8921122920945661 0.02906491459357258 1.789831593372143e-06 1.243294087305498e-07 0.0281425137535819 0.009380660848320635 3.739256802781553e-11 10.427214707565453 -0.17729941345935796 QFLFRPWDVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QFLFRPWDVTK 11 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 57792000.0 27624000.0 10406000.0 19762000.0 False True 22970579.950695157 10349940.812570708 23894142.830835868 1.0 0.45057377022200473 1.0402063370678092 24.453283945891656 -11.894240949161821 14.301152698208 0.9109661218280533 0.7708510482804228 0.0 0.27546267049724193 0.0 0.0 0.0 0.0800292660996575 1.275730829381489e-12 11.894240949161821 -0.14011507354763042 QFLFRPWDVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFLFRPWDVTK 11 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 71313400.0 14593900.0 33832500.0 22887000.0 False True 18892091.238776688 31949691.63384229 18721800.840451136 1.0 1.6911675488981555 0.9909861541439084 24.171279072281042 -10.439178403420332 5.453963543933293 0.9997020442968179 1.3410768515210338 0.24034643068138384 0.2858478574230314 0.0010365107123655023 0.00010658244489206972 0.2770088684745136 0.09225699927903838 3.637655745136805e-11 10.439178403420332 0.341374807224216 QFLPFLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFLPFLQR 8 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 49485000.0 14192000.0 13989000.0 21304000.0 False True 18605849.43552352 11901895.728694921 19099666.44239808 1.0 0.63968569507883 1.0265409546920083 24.149252921294025 -11.804012922246919 17.171410386115696 0.9015366976390848 0.8498019923968771 0.0 0.1806884617970512 0.0 0.0 0.0 0.052499123166479374 1.5703160795538016e-12 11.804012922246919 -0.05173470524220769 QFLPFLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFLPFLQR 8 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 31643400.0 12424000.0 4996400.0 14223000.0 False True 12029606.920553759 6991488.575881792 10497569.619146097 1.0 0.581190110537706 0.8726444420399119 23.52008616599129 -10.138256720096663 5.5229618431244445 1.0000047524654945 0.72691727628876 0.5392850976534906 0.11898573258423645 6.962977917627811e-06 1.086402839396752e-06 0.11520944491429623 0.03840248006122799 7.273497265614298e-11 10.138256720096663 -0.27308747617673446 QFLPFLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFLPFLQR 8 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 32924400.0 6661000.0 21184000.0 5079400.0 False True 10105223.984328946 17403549.688652564 4075454.3636198943 1.0 1.7222329475963887 0.4033017348195406 23.268597963910317 -6.758048701504008 1.6200059132511337 1.4205408545275617 0.3989768589653229 0.6828484387486856 0.3036929262503595 0.28622296723070445 1.4800581435014024 0.14794817965565524 0.35620420588672064 1.7456263885232538e-07 6.758048701504008 -1.0215639955622389 QFLPFLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFLPFLQR 8 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 49254000.0 14192000.0 16095000.0 18967000.0 False True 19439165.924379196 15383869.680952469 14487385.237626739 1.0 0.7913852755204447 0.7452678419426272 24.212462982816916 -13.99999999999997 0.21209185714207096 2.2169876101388195 0.7186492099085499 0.9994912868215083 0.0024995668827727012 12.796509259289445 0.1459554511520157 6.4961607814034625 0.026922872439719147 1.0000000000000696e-14 13.99999999999997 -1.4983384002302698 QFLPFLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QFLPFLQR 8 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 27387700.0 12424000.0 7904400.0 7059300.0 False True 10331106.476521723 7861817.428299451 8535366.991484635 1.0 0.7609850354525015 0.8261813011880139 23.300491441425567 -10.098325719093978 5.644289174347191 1.0000016804853284 0.7935831683202236 0.930388522004507 0.026616264031271503 5.628425633783208e-07 8.99120355820563e-08 0.025771296688083832 0.008590362277596925 7.97396418877599e-11 10.098325719093978 -0.20641851216510487 QFLPFLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFLPFLQR 8 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 26031800.0 6661000.0 8700800.0 10670000.0 False True 8622795.807939714 8216592.8313821 8728169.483445352 1.0 0.9528919638589157 1.0122203607568454 23.039724286002766 -6.695129390793506 1.847878517637976 0.9706086704326738 1.0120302581633394 0.39452156404812444 0.019903312621413902 0.40582039041301043 2.6904263564773996 0.00860340514007417 0.022262665963455514 2.017765114675902e-07 6.695129390793506 0.04142158773066551 QFLSQFEMQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFLSQFEMQSR 11 0 Q16630;Q16630-2;F8WJN3;Q16630-3 Q16630 CPSF6 Cleavage and polyadenylation specificity factor subunit 6 0 14235400.0 4448000.0 3910900.0 5876500.0 False True 5831371.07449327 3327408.964568802 5268456.151368395 1.0 0.570604909559446 0.9034678267025237 22.475403699716466 -9.811536120052905 6.179411969812487 1.000000011909342 0.7370363681307927 0.45419182933329494 0.1358907168831624 2.218102203941005e-08 4.441978655158679e-09 0.13157562672975132 0.043858540282622135 1.543348058507371e-10 9.811536120052905 -0.2629636437785493 QFLSQFEMQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFLSQFEMQSR 11 0 Q16630;Q16630-2;F8WJN3;Q16630-3 Q16630 CPSF6 Cleavage and polyadenylation specificity factor subunit 6 0 9325200.0 4448000.0 0.0 4877200.0 False True 6092545.80268028 0.0 3725305.809086999 1.0 0.0 0.6114530657197741 22.538613761239358 -10.13605368844043 6.823424580509906 1.0000008840118155 0.305726532859887 0.6322165184947659 0.24962466877898662 3.3571081726101297e-06 4.2490108251459455e-07 0.24169835233308526 0.08056601541529639 7.310487040460771e-11 10.13605368844043 -0.6942743511519285 QFLTQLMQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFLTQLMQK 9 0 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 4971200.0 1048800.0 1724200.0 2198200.0 False True 1374986.9565936471 1466956.0808789614 1970751.35062333 1.0 1.0668872703441172 1.4332873058706044 20.39098650232735 -6.937791313101613 0.6798008040235434 0.9956879127601714 1.5259880801137955 0.9978600666055688 0.008810372869297041 0.08878881403703566 0.0593075026446936 0.008438994895002352 0.03185433877121009 1.1540076476076348e-07 6.937791313101613 0.5303001673536241 QFLTQLMQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFLTQLMQK 9 0 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 7234100.0 1048800.0 3250900.0 2934400.0 False True 1436569.7027542891 3107264.4887113026 2241355.155865023 1.0 2.1629750945978072 1.5602132994784341 20.454196563850243 -10.147573279011334 5.595201994299361 0.9999853511654013 1.8615941970382168 0.731492217350624 0.24607647241475225 4.4967538822759026e-05 6.850426160923681e-06 0.23826656227087542 0.07942083996293443 7.11912668014811e-11 10.147573279011334 0.8616088458728155 QFMAETQFTSGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFMAETQFTSGEK 13 0 Q14444-2;Q14444;G3V153 Q14444-2 CAPRIN1 Caprin-1 0 10783900.0 2228200.0 3989500.0 4566200.0 False True 2921191.777919493 3394282.1509492 4093733.42608327 1.0 1.161951151788688 1.4013915337660148 21.47812564435919 -6.96549633238191 0.349429050752912 0.9767084380544486 1.5947067486298105 0.9999230132123793 0.0014466991169406957 0.07779293545616302 0.014268319180762023 0.0032914929918057404 0.020588377653624135 1.0826888583990677e-07 6.96549633238191 0.6179983105753619 QFMAETQFTSGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFMAETQFTSGEK 13 0 Q14444-2;Q14444;G3V153 Q14444-2 CAPRIN1 Caprin-1 0 8044300.0 2228200.0 1862400.0 3953700.0 False True 3052025.7548408727 1780113.0098667839 3019917.4890074744 1.0 0.5832562215581945 0.9894796871283046 21.54133570588208 -10.799258017309 10.150593953493118 1.0019589170425287 0.7863679549434563 0.2694106944037329 0.16584003536530337 0.007403811644644533 0.0001464202441355091 0.1617079475604707 0.05352464125868909 1.5876032624508484e-11 10.799258017309 -0.21559096209907236 QFMAETQFTSGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QFMAETQFTSGEK 13 0 Q14444-2;Q14444;G3V153 Q14444-2 CAPRIN1 Caprin-1 0 6714600.0 3241000.0 1748400.0 1725200.0 False True 2695035.100644471 1738981.0221697725 2085931.3435764618 1.0 0.6452535708176584 0.7739904178159488 21.361872632356107 -10.330559404801884 6.340764284593064 1.0000165271567831 0.7096219950059 0.8715247958259605 0.05255659770676012 1.227989926867987e-05 1.2964329254931954e-06 0.05089060069514025 0.016962568970967033 4.6713305018896296e-11 10.330559404801884 -0.2903945321508832 QFNTLIPWCLPHTGNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFNTLIPWCLPHTGNR 16 0 P26358;P26358-2;P26358-3;K7ENW7 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 0 7640900.0 1702900.0 2398000.0 3540000.0 False True 2232518.3909070604 2040227.7473307883 3173714.7580777863 1.0 0.9138682824027509 1.4215850453927605 21.090240629266923 -6.863230153336048 1.169224966027328 0.9527997449362897 1.4477417769086345 0.9574518303069867 0.045760020381892176 0.143515927391445 0.37098548782782487 0.030481117434803338 0.07143517081781971 1.3701554630755177e-07 6.863230153336048 0.49494203197234476 QFNYTHICAGASAFGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFNYTHICAGASAFGK 16 0 P13804;P13804-2;H0YL12;H0YLU7;H0YNX6;H0YKF0 P13804 ETFA Electron transfer flavoprotein subunit alpha, mitochondrial 0 65860000.0 17407000.0 22362000.0 26091000.0 False True 22820745.569627807 19025676.766393308 23391353.602544468 1.0 0.8337009283217562 1.0250039172110172 24.443842590458363 -6.67690730439718 1.9130286737135758 0.8944876519411451 1.0242561158994774 0.3099228019114415 0.07053007371548274 0.4454530083068006 3.1491518671602288 0.02961390751144182 0.07841113554808873 2.1042275171363442e-07 6.67690730439718 0.1297684639583323 QFNYTHICAGASAFGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFNYTHICAGASAFGK 16 0 P13804;P13804-2;H0YL12;H0YLU7;H0YNX6;H0YKF0 P13804 ETFA Electron transfer flavoprotein subunit alpha, mitochondrial 0 27535400.0 13108000.0 3867400.0 10560000.0 False True 12691893.714956433 5411672.988224574 7794019.206790598 1.0 0.4263881426809719 0.6140942700777535 23.59740400914675 -10.128411231785224 5.515661161111012 1.0000074754032748 0.5202412063792643 0.897015423302112 0.07663070561968492 7.044429325416336e-06 1.1131461874444347e-06 0.0741985174786931 0.024732453889378492 7.440271238085458e-11 10.128411231785224 -0.47976626902401054 QFNYTHICAGASAFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFNYTHICAGASAFGK 16 0 P13804;P13804-2;H0YL12;H0YLU7;H0YNX6;H0YKF0 P13804 ETFA Electron transfer flavoprotein subunit alpha, mitochondrial 0 83070000.0 15335000.0 36527000.0 31208000.0 False True 23264316.138670534 30008471.46324638 25039725.12104767 1.0 1.2898926959372574 1.07631468605372 24.471615443490265 -10.287215980351581 3.6074423559737747 0.9995256138606806 1.1831036907318089 0.4949459069858505 0.08719285838169646 9329124.703930773 5320812.947975401 33780.03106166376 0.029848434364449346 5.161596124765454e-11 10.287215980351581 0.18357807687112826 QFNYTHICAGASAFGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFNYTHICAGASAFGK 16 0 P13804;P13804-2;H0YL12;H0YLU7;H0YNX6;H0YKF0 P13804 ETFA Electron transfer flavoprotein subunit alpha, mitochondrial 0 56475000.0 17407000.0 20330000.0 18738000.0 False True 23842838.306487355 19431753.37768027 14312470.3212237 1.0 0.8149932960117888 0.6002838310290199 24.507052651981255 -6.969170626439032 0.2772901585349912 1.0488716507840752 0.35988702689777735 0.9999751661437545 0.0008139290884464866 0.07657283408496589 0.009990109936446081 0.004028886548432599 0.019775941163164185 1.073567544223328e-07 6.969170626439032 -0.6889846238862978 QFNYTHICAGASAFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QFNYTHICAGASAFGK 16 0 P13804;P13804-2;H0YL12;H0YLU7;H0YNX6;H0YKF0 P13804 ETFA Electron transfer flavoprotein subunit alpha, mitochondrial 0 24477400.0 13108000.0 3702900.0 7666500.0 False True 10899882.782859528 3682951.7427318958 9269529.704109041 1.0 0.33788911459887205 0.8504247145378225 23.377809284581026 -10.040989681959875 7.002006056833267 1.0000000782279765 0.59415691456849 0.4553380838240123 0.2092417824769478 2.555622700043311e-07 3.492342807208139e-08 0.2025975239618609 0.06753249490533106 9.099348907590675e-11 10.040989681959875 -0.4058431636594866 QFNYTHICAGASAFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFNYTHICAGASAFGK 16 0 P13804;P13804-2;H0YL12;H0YLU7;H0YNX6;H0YKF0 P13804 ETFA Electron transfer flavoprotein subunit alpha, mitochondrial 0 96599000.0 15335000.0 47792000.0 33472000.0 False True 19851459.798041668 45132333.18745562 27380439.451722868 1.0 2.2735019815473665 1.379265793562644 24.242741765582714 -10.122925044574929 4.5999016780482895 0.9999249078678198 1.826383887572595 0.5324197143912202 0.36507039507431904 43590112.817747034 95928056.40930969 20454.880544768093 0.12497330517647215 7.53485597528968e-11 10.122925044574929 0.8264589797047752 QFQFGHALKPQVSSIFTSFLDGLKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFQFGHALKPQVSSIFTSFLDGLKK 25 2 A0A1B0GWA2;A0A2R8YEL0;O00116 A0A1B0GWA2 AGPS Alkyldihydroxyacetonephosphate synthase, peroxisomal 0 132615200.0 8311700.0 32353500.0 91950000.0 False True 12609456.566663709 26579765.145950712 73776042.19688334 1.0 2.107923129393304 5.850850257252877 23.588002764978906 -6.948754636643532 0.5723519624609782 0.9538563926415597 7.18763214535466 0.9990998992959826 0.06226723286237557 0.08398969668757604 0.03806183423954227 0.06579273066235548 0.31204173915628536 1.1252405215626675e-07 6.948754636643532 6.2337757527131 QFQFGHALKPQVSSIFTSFLDGLKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFQFGHALKPQVSSIFTSFLDGLKK 25 2 A0A1B0GWA2;A0A2R8YEL0;O00116 A0A1B0GWA2 AGPS Alkyldihydroxyacetonephosphate synthase, peroxisomal 0 51021100.0 8311700.0 20642000.0 22067400.0 False True 10759659.498101272 19493254.554223668 18051359.630644973 1.0 1.811698089299535 1.6776887441308388 23.359129087071356 -10.426618582021504 5.705374799988676 0.999601322598442 1.744693416715188 0.9762887369699941 0.054709086071306284 0.00027757944945733595 2.7896342075873387e-05 0.052998736021207866 0.01765728160336583 3.744392942268045e-11 10.426618582021504 0.7450920941167459 QFQYLHVLLDLSSHEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFQYLHVLLDLSSHEK 16 0 Q92797;A0A087WUE9 Q92797 SYMPK Symplekin 0 20580600.0 2859800.0 10552000.0 7168800.0 False True 4338525.679385064 8668913.156847706 5751883.537803338 1.0 1.9981242010480447 1.325769158203669 22.048773437708828 -10.498094787708377 4.972173601719925 0.9978852299074628 1.6619466796258864 0.5637705587119042 0.2744877968260766 0.006451528257745857 0.0006512347518225857 0.26646310339075724 0.08859055548703196 3.1761807720558044e-11 10.498094787708377 0.6640614497184236 QFSSASSQQGQEEKEEDLK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFSSASSQQGQEEKEEDLKK 20 2 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 34447400.0 6126500.0 6922900.0 21398000.0 True False 7930875.021369575 6537634.529281813 17503783.562020972 1.0 0.8243270145685432 2.2070431717631913 22.919048618021105 -6.875008968391173 1.1072113612052743 0.8968874752568577 2.296136600737476 0.969433812322279 0.10745356820769278 0.13214519810246025 0.29975858443382786 0.07506231754412213 0.17943630625388837 1.333493894584895e-07 6.875008968391173 1.399249125480618 up QFSSASSQQGQEEKEEDLKKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFSSASSQQGQEEKEEDLKKK 21 3 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 1 37934300.0 3599900.0 4733400.0 29601000.0 True False 5461311.487942625 3888687.787777001 23750349.375420783 1.0 0.7120428483821823 4.348836250753383 22.38081601313407 -6.887751372002828 1.0356304418332474 0.7939262217652009 4.6481510254226075 0.9794181752406104 0.2368183556450045 0.12098500530480694 0.23267575592371423 0.17473354025165466 0.4322172734847009 1.2949369640212806e-07 6.887751372002828 3.8542248036574067 up QFTEK(ub)MQSDMEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFTEKMQSDMEK 12 1 P14373;A0A140T9V9;H0Y551;P14373-2 P14373 TRIM27 Zinc finger protein RFP 1 43342300.0 6020300.0 24857000.0 12465000.0 True False 7793397.027854607 23473686.098940883 10196497.901700698 1.0 3.011996696054737 1.308350885404285 22.893820884385757 -6.605532618167859 2.1704879472607788 2.3482667657246994 1.3142435794532314 0.03661979375779467 0.8684347905867728 0.6251283566610862 5.574051401249889 0.33118770672143183 0.9647465269833458 2.4800896608181625e-07 6.605532618167859 -1.034023186271468 QFTLALGTTQDENGK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFTLALGTTQDENGKK 16 1 Q9NXE4-3;Q9NXE4-2;Q9NXE4;Q9NXE4-4;H7C1Q6;Q9NXE4-6;Q9NXE4-9;Q9NXE4-10;Q9NXE4-7;Q9NXE4-8;Q9NXE4-5;H7C235 Q9NXE4-3 SMPD4 Sphingomyelin phosphodiesterase 4 1 5879200.0 1972600.0 1607600.0 2299000.0 True False 2701923.527510594 1536570.916377708 1756023.5493912508 1.0 0.5686951909380726 0.6499160807149696 21.36555541199573 -10.83655064377031 7.360361112753912 1.0244788415394956 0.6093056358265216 0.9686043916244396 0.033158289401372054 0.0120770048578057 0.00026819012906701073 0.029110726560834695 0.010701791886686659 1.456965795725087e-11 10.83655064377031 -0.415173205712974 QFVFDLHSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFVFDLHSGK 10 0 Q9BS26 Q9BS26 ERP44 Endoplasmic reticulum resident protein 44 0 9518600.0 3086900.0 2968800.0 3462900.0 False True 4046955.7935821223 2525866.612291764 3104592.326482364 1.0 0.6241399069140853 0.7671426338300487 21.948405659317878 -10.196497574834517 4.837921651122025 1.0000394551271452 0.6956412703712158 0.8579502466751495 0.05838061879804956 2.4847893720405903e-05 4.12687664914244e-06 0.05653410787305074 0.018842263695092853 6.360663567172188e-11 10.196497574834517 -0.3043981847559294 QFVFDLHSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFVFDLHSGK 10 0 Q9BS26 Q9BS26 ERP44 Endoplasmic reticulum resident protein 44 0 8892300.0 3519100.0 1544900.0 3828300.0 False True 3407388.0967579526 2161786.6265470674 2825553.383461791 1.0 0.6344409750694249 0.8292431925057897 21.700234847072686 -10.064843650841466 4.939759689758607 1.0000062934668537 0.7318420837867646 0.7164387504290779 0.07952767225392143 5.641319632816379e-06 1.0679742989441856e-06 0.07700418680259218 0.025667445849179637 8.613037719718185e-11 10.064843650841466 -0.268164209680089 QFVFDLHSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFVFDLHSGK 10 0 Q9BS26 Q9BS26 ERP44 Endoplasmic reticulum resident protein 44 0 15028200.0 3275800.0 7635000.0 4117400.0 False True 4969628.093058812 6272474.597472722 3303594.0852794726 1.0 1.262161771468095 0.6647568034102339 22.244706459667917 -6.78742367331103 1.5066158195058514 1.1470144495850951 0.658846708110565 0.7928675617376788 0.11127504335857702 0.2392139328638412 1.0727267518474295 0.058143608604878154 0.13638800347596172 1.6314596109329334e-07 6.78742367331103 -0.4881677414745301 QFVFDLHSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFVFDLHSGK 10 0 Q9BS26 Q9BS26 ERP44 Endoplasmic reticulum resident protein 44 0 8747500.0 3086900.0 3191500.0 2469100.0 False True 4228210.350335828 3050488.977120837 1885949.4327107149 1.0 0.7214610259110099 0.4460396424129945 22.01161572084077 -6.97126438916399 0.22596690073478123 1.1178195855691018 0.04184936554482734 0.9999906326758874 0.0006921464878308109 0.07589460435856431 0.007545890153458828 0.0072920326619815 0.027573650627167257 1.068404259607544e-07 6.97126438916399 -1.0759702200242744 down QFVFDLHSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QFVFDLHSGK 10 0 Q9BS26 Q9BS26 ERP44 Endoplasmic reticulum resident protein 44 0 6459000.0 3519100.0 1585500.0 1354400.0 False True 2926287.5725633977 1576958.5968028896 1637598.7779619514 1.0 0.5388939253914441 0.559616489273278 21.480640122506962 -10.52570279013511 6.819237031856606 1.0002627759534342 0.5492552073323611 0.998417298184843 0.008459951278786888 3.38171356588848e-05 2.3520731639243337e-06 0.00819594790900093 0.0027304375343723177 2.980555477772061e-11 10.52570279013511 -0.45100756862107305 QFVFDLHSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFVFDLHSGK 10 0 Q9BS26 Q9BS26 ERP44 Endoplasmic reticulum resident protein 44 0 13572000.0 3275800.0 6083100.0 4213100.0 False True 4240587.675671657 5744570.137525336 3446359.0300565725 1.0 1.3546636874134355 0.8127078824070562 22.015832781760366 -6.730130055682396 1.7226180440297147 1.2134031620251517 0.8130149189078216 0.5599182554273823 0.14909083550701355 0.33600031989344764 1.9533512823041017 0.0685829266893402 0.17016778221233228 1.8615295915740693e-07 6.730130055682396 -0.4003882431173301 QFVVFEGNHYFYSPYPTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFVVFEGNHYFYSPYPTK 18 0 P04843 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 12532900.0 4345900.0 4404600.0 3782400.0 False True 5697516.985755462 3747450.8489963305 3391033.5313427765 1.0 0.6577340371894367 0.5951774325238176 22.44190188986409 -13.999999999999998 0.23901910847436747 3.254753904018154 0.5672594796112145 0.9995233488316189 0.003884684800338492 13.588983527698137 0.15474137339095048 14.616199408478634 0.030744667485511776 1.0000000000000041e-14 13.999999999999998 -2.68749442440694 QFVVFEGNHYFYSPYPTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFVVFEGNHYFYSPYPTK 18 0 P04843 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 13529100.0 4345900.0 4061400.0 5121800.0 False True 5952696.673531525 3881953.9187462144 3912136.3267821306 1.0 0.6521336684274873 0.6572040440389512 22.505111951386983 -9.934383822313741 5.673478565260049 1.0000003108029936 0.6546688562329364 0.9998383397669944 0.0020699721768842215 8.138012644390304e-09 1.5292122267437698e-09 0.002004243748225359 0.0006680806471312384 1.1630976484895669e-10 9.934383822313741 -0.3453314545700572 QFYDQALQQAVVDDDANNAK(ub)AVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFYDQALQQAVVDDDANNAKAVVK 24 1 E9PJK1;E9PRJ8;H0YDL9;H0YDJ9;E9PIF1;A6NMH8;P60033;E9PM31;H0YEE2 E9PJK1 CD81 Tetraspanin;CD81 antigen 1 46987200.0 7764200.0 21856000.0 17367000.0 True False 11778859.039052222 17955626.038292598 13934404.837773478 1.0 1.5243943389390782 1.1830012390482516 23.489696463276218 -10.201411567333764 5.003459480751551 0.9999642855411441 1.3536977889923711 0.5886769299836964 0.1393731494079849 5.554208895221153e-05 8.86481754442271e-06 0.13496107734672813 0.04498249054693389 6.289099020665609e-11 10.201411567333764 0.353733503451227 QFYDQALQQAVVDDDANNAK(ub)AVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFYDQALQQAVVDDDANNAKAVVK 24 1 E9PJK1;E9PRJ8;H0YDL9;H0YDJ9;E9PIF1;A6NMH8;P60033;E9PM31;H0YEE2 E9PJK1 CD81 Tetraspanin;CD81 antigen 1 34663200.0 7764200.0 14606000.0 12293000.0 True False 10050909.955262808 13793163.2602941 10055800.136831652 1.0 1.3723298011511675 1.0004865411779242 23.260822785368667 -10.195092681166873 13.420604927175207 0.9999998927167675 1.18640817109173 0.2509813413274906 0.151804375204599 1.074159727886273e-10 0.0 0.14698395426220284 0.04899465142073427 6.381272912915535e-11 10.195092681166873 0.18640827837496254 QFYINVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 QFYINVER 8 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;Q14240-2;Q14240;E7EQG2;J3KTN0 P60842;Q14240-2;J3KTN0 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 47731000.0 13893000.0 14336000.0 19502000.0 False True 18213857.54000338 12197124.681290317 17484120.116393473 1.0 0.669661803080516 0.9599350427548269 24.11853316941781 -10.216775792634948 7.462931420244569 1.0000002645429682 0.8147984237426351 0.3518143285146793 0.11850355386444458 5.216284960158102e-07 5.4755382868346975e-08 0.11474073678135893 0.03824685754861561 6.070496420524374e-11 10.216775792634948 -0.18520184080033308 QFYINVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 QFYINVER 8 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;Q14240-2;Q14240;E7EQG2;J3KTN0 P60842;Q14240-2;J3KTN0 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 26201400.0 9300500.0 3878900.0 13022000.0 False True 9005260.71833631 5427764.998196281 9611147.548373803 1.0 0.6027326879214487 1.067281431264261 23.10233661465127 -6.680295217603224 1.9009722888791265 0.7487057975652912 1.0655104470625174 0.32538006022011945 0.1683613798062362 0.4378891128853675 3.0597047686979555 0.07106166199793683 0.18734031110641586 2.0878763858854214e-07 6.680295217603224 0.3168046494972262 QFYINVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 QFYINVER 8 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;Q14240-2;Q14240;E7EQG2;J3KTN0 P60842;Q14240-2;J3KTN0 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 86645000.0 18055000.0 41856000.0 26734000.0 False True 27390754.997306626 34386469.77757932 21450013.18207155 1.0 1.2554042333247328 0.7831114251571657 24.707185697171887 -6.759802403422129 1.6129471050058881 1.148384859899268 0.7813856867128027 0.6902952807900868 0.1074213144420444 0.2832328964414795 1.4521888422722975 0.052545872232428 0.12631409149840245 1.7385916783681433e-07 6.759802403422129 -0.36699917318646536 QFYINVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QFYINVER 8 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;Q14240-2;Q14240;E7EQG2;J3KTN0 P60842;Q14240-2;J3KTN0 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 38610800.0 13893000.0 9742800.0 14975000.0 False True 19029617.544207998 9312330.880868828 11438213.419806 1.0 0.4893598549332486 0.6010742671645245 24.1817432309407 -9.760290274115794 6.161771785416307 1.0000000104470999 0.5452170610482141 0.9567038886728902 0.04560721781623741 6.5395572231627384e-09 1.3882800606300533e-09 0.044158999424140255 0.014719666255373638 1.736639704030996e-10 9.760290274115794 -0.45478294939888575 QFYINVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QFYINVER 8 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;Q14240-2;Q14240;E7EQG2;J3KTN0 P60842;Q14240-2;J3KTN0 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 20203400.0 9300500.0 6356300.0 4546600.0 False True 7733777.832009848 6322057.350273232 5497273.038896779 1.0 0.8174604297664781 0.7108134159406221 22.882741890085548 -13.999999999996561 0.05872535661451361 2.1782283778338405 0.21445401561581875 0.9999573924219306 0.0007794042667086513 12.477283482256645 0.06146815928178455 2.1866825606979567 0.46647017679049246 1.0000000000079186e-14 13.999999999996561 -1.9637743622180217 QFYINVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QFYINVER 8 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;Q14240-2;Q14240;E7EQG2;J3KTN0 P60842;Q14240-2;J3KTN0 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 72866000.0 18055000.0 29051000.0 25760000.0 False True 23372553.41725744 27434286.31211864 21071944.31992053 1.0 1.1737821633070764 0.9015679178793436 24.478312019264337 -6.734242972443835 1.7076349801850483 1.1040832138044332 0.9015963542373219 0.5788730264082067 0.073032824906788 0.3283420899361571 1.8775483178856993 0.03386548910371924 0.08363827892291698 1.8439834868231283e-07 6.734242972443835 -0.20248685956711132 QGAAIGIPYFTAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGAAIGIPYFTAYR 14 0 Q08257-3;Q08257;C9JH92;A6NP24 Q08257-3 CRYZ Quinone oxidoreductase 0 12056800.0 4047600.0 4277800.0 3731400.0 False True 5306442.797014163 3639568.914733802 3345310.5221162294 1.0 0.6858773483399689 0.6304243068442336 22.33931363584488 -13.999999999999998 0.2439461212481361 3.1196627724845833 0.6068073140624389 0.9995316874624546 0.003521594152042401 13.76608237962314 0.15630611689016483 14.247492150585023 0.026482183773851517 1.0000000000000041e-14 13.999999999999998 -2.5128554584221443 QGAAIGIPYFTAYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGAAIGIPYFTAYR 14 0 Q08257-3;Q08257;C9JH92;A6NP24 Q08257-3 CRYZ Quinone oxidoreductase 0 15127500.0 4700800.0 2882200.0 7544500.0 False True 4551575.677087831 4033077.4904744457 5568369.1198514905 1.0 0.886083804071752 1.2233937244814128 22.11793463727291 -6.815607872862479 1.3908116755036273 0.9383136901537872 1.2300837197814383 0.8739654267069437 0.04973845132445338 0.19925604690189902 0.7585103006357451 0.02811118618636363 0.06487847545852707 1.5289459298058537e-07 6.815607872862479 0.2917700296276511 QGAAIGIPYFTAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGAAIGIPYFTAYR 14 0 Q08257-3;Q08257;C9JH92;A6NP24 Q08257-3 CRYZ Quinone oxidoreductase 0 11652200.0 4047600.0 3673600.0 3931000.0 False True 5544107.102277145 3511288.205029323 3002578.7614863007 1.0 0.6333370081517947 0.5415802231261089 22.402523697367773 -13.999999999999995 0.19454087102443435 2.9973551452515723 0.47867812607642607 0.9994875460526036 0.004483313996335366 12.428243738969783 0.13987114842420967 9.425108560136342 0.06089683697874958 1.0000000000000123e-14 13.999999999999995 -2.518677019175146 QGAAIGIPYFTAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGAAIGIPYFTAYR 14 0 Q08257-3;Q08257;C9JH92;A6NP24 Q08257-3 CRYZ Quinone oxidoreductase 0 10393300.0 4700800.0 3031400.0 2661100.0 False True 3908923.48074963 3015069.246514214 3217523.706463781 1.0 0.7713298204384401 0.8231227145553496 21.898339912707186 -10.785644052127044 7.0295280908784195 1.0063123422193994 0.7972262674969408 0.9533521518054138 0.021144360481404157 0.0021346868399642893 6.509433962079889e-05 0.02089302142486321 0.006824313000890378 1.6381586065959657e-11 10.785644052127044 -0.20908607472245855 QGAIVAVTGDGVNDSPALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGAIVAVTGDGVNDSPALK 19 0 P05023-4;P05023;P05023-3;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 0 6341100.0 1164600.0 2591300.0 2585200.0 False True 1526801.8780024434 2204688.140808285 2317708.3029894615 1.0 1.443990980475305 1.5180150983451648 20.542081435540418 -11.915703123112822 0.2930547734290067 5.635167923017501e-23 1.5395050906702346 0.9994409189952563 0.005408813132666963 4.969933034193921 0.16143522397632792 3.0648019261432586 0.027545831691421965 1.2142185875920505e-12 11.915703123112822 1.5395050906702346 QGAIVAVTGDGVNDSPALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGAIVAVTGDGVNDSPALK 19 0 P05023-4;P05023;P05023-3;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 0 4665500.0 1164600.0 1594800.0 1906100.0 False True 1595184.0921316233 1524336.462701645 1455918.4373617491 1.0 0.9555865496782221 0.9126961863167935 20.60529149706331 -6.971551604490499 0.2179726099307046 1.0202925431079042 0.8467819431342851 0.9999920596910756 0.0001002719850138101 0.07580243878662257 0.007201323914620651 0.001206681781050529 0.004366030264847656 1.0676979171517224e-07 6.971551604490499 -0.17351059997361906 QGAIVAVTGDGVNDSPALK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGAIVAVTGDGVNDSPALKK 20 1 P05023-4;P05023;P05023-3;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 1 20181500.0 2661800.0 6012700.0 11507000.0 True False 3489645.576907864 5115628.597321031 10316366.022938158 1.0 1.4659450321181133 2.9562790247826185 21.734649087019086 -6.9500017825626665 0.5588226914195102 0.9803870262046768 3.5129188587320033 0.9992014328618063 0.02357777847175973 0.08348500622191309 0.035959205695815274 0.025310119263002043 0.12385572771335172 1.1220138489841745e-07 6.9500017825626665 2.5325318325273267 up QGAIVAVTGDGVNDSPALK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGAIVAVTGDGVNDSPALKK 20 1 P05023-4;P05023;P05023-3;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 1 20818300.0 2016100.0 5256200.0 13546000.0 True False 1952100.0090573442 7355028.070720899 9997896.228710752 1.0 3.7677516708135217 5.121610666626998 20.89659553558312 -8.830563084288446 0.30570725732088083 1.660461682123634e-21 5.7384306385408514 0.998573697453272 0.0647816847711138 0.35126697318722616 0.09976601498918991 0.8547954856374339 0.44536812613556964 1.4771918936273165e-09 8.830563084288446 5.7384306385408514 QGAIVAVTGDGVNDSPALK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGAIVAVTGDGVNDSPALKK 20 1 P05023-4;P05023;P05023-3;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 1 15755100.0 2661800.0 3500000.0 9593300.0 True False 3645939.392440279 3345358.427047761 7327560.120215345 1.0 0.9175573335048406 2.0097865958520242 21.797859148541978 -6.888699273790624 1.0300070415828193 0.9394705010276017 2.1013825335426515 0.9800540532213686 0.07013371579073077 0.12020646224096786 0.22804335831712616 0.051966150099914524 0.1289652065597144 1.2921136850435011e-07 6.888699273790624 1.1619120325150498 up QGAIVAVTGDGVNDSPALK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGAIVAVTGDGVNDSPALKK 20 1 P05023-4;P05023;P05023-3;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9 P05023-4 ATP1A1;ATP1A3;ATP1A2 Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2 1 15541600.0 2016100.0 4134000.0 9391500.0 True False 1676476.4783737487 4111729.321465247 11355219.228610195 1.0 2.4526018554425493 6.7732648653831555 20.677000811017397 -6.951642937096058 0.5405060071836885 0.9365995687137112 8.488968616336361 0.9993239880645683 0.06375140331013607 0.0828326551435208 0.03328339662267512 0.0700706723021197 0.3578410566558397 1.1177818742711814e-07 6.951642937096058 7.55236904762265 QGAK(ub)INEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGAKINEIR 9 1 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0;Q15366-6;Q15366;H3BRU6;H3BSS4 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 1 48788000.0 14214800.0 20035400.0 14537800.0 True False 18635740.456318993 17046196.417377517 13033567.912424626 1.0 0.9147045408435867 0.6993855673711754 24.151568807208356 -6.955253247986932 0.49784477344023564 1.0043939045893393 0.6004432917517044 0.9995516460906684 0.00267842466035114 0.0814423872461632 0.027744404163244363 0.0031539796380551425 0.017760709886993638 1.1085282161967684e-07 6.955253247986932 -0.4039506128376349 QGAK(ub)INEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGAKINEIR 9 1 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0;Q15366-6;Q15366;H3BRU6;H3BSS4 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 1 56591300.0 13521300.0 18937700.0 24132300.0 True False 13092073.732685415 26499622.36880084 17811326.676518284 1.0 2.0240966335716855 1.3604664196208178 23.64219029678171 -10.212674567639954 4.94250603885152 0.99991109670622 1.6922815265971904 0.5919946481883772 0.27092590034888353 0.0002654462681285125 4.228557452962501e-05 0.26235628732770305 0.08744095834182211 6.128094196963704e-11 10.212674567639954 0.6923704298909704 QGAK(ub)INEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QGAKINEIR 9 1 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0;Q15366-6;Q15366;H3BRU6;H3BSS4 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 1 135241000.0 22247000.0 24875000.0 88119000.0 True False 33750325.47355746 20435861.90073793 70702241.0260702 1.0 0.6055011800330317 2.0948610134578898 25.008398079169766 -6.836265065409994 1.2996104872448915 0.7899333309466813 2.1403409413102605 0.9178469597746433 0.18058400368915475 0.1732026670748657 0.5698593859551401 0.1090193597469375 0.25096624467271306 1.4579241655643793e-07 6.836265065409994 1.3504076103635794 up QGAK(ub)INEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGAKINEIR 9 1 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0;Q15366-6;Q15366;H3BRU6;H3BSS4 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 1 40846900.0 14214800.0 12513200.0 14118900.0 True False 19470395.700525988 11960325.44838115 10784306.607873052 1.0 0.6142826079316942 0.5538822514830408 24.214778868731248 -13.999999999999998 0.2609906883035309 3.8382786033124723 0.5320148978809579 0.999564361798637 0.004124500059565347 14.461110139459588 0.1616679311348428 21.660236019638955 0.026269052798354613 1.0000000000000041e-14 13.999999999999998 -3.3062637054315145 QGAK(ub)INEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGAKINEIR 9 1 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0;Q15366-6;Q15366;H3BRU6;H3BSS4 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 1 53171600.0 13521300.0 26070700.0 13579600.0 True False 11243560.045153994 25930251.964471225 16419031.5750237 1.0 2.3062314658645184 1.4603054111940592 23.422595572215986 -10.07460640011248 4.859565874872805 0.9999723411355589 1.883268438536948 0.5924436350018176 0.3453478657080373 0.00010523351176845942 2.0038336553714294e-05 0.3343922421537875 0.1114605443736879 8.421580413891852e-11 10.07460640011248 0.8832960974013891 QGAK(ub)INEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QGAKINEIR 9 1 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0;Q15366-6;Q15366;H3BRU6;H3BSS4 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 1 92947500.0 22247000.0 16075000.0 54625500.0 True False 28799180.053931084 15180412.11893932 44684219.504962 1.0 0.5271126501001613 1.55157957349076 24.779524401262215 -6.7812050114208455 1.5312328998288267 0.732652941329794 1.5599933139477244 0.7715879632134448 0.20008220333429527 0.24872048424518495 1.1519520286256386 0.102909048134771 0.24257287763089322 1.6549885313781895e-07 6.7812050114208455 0.8273403726179305 QGANINEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGANINEIR 9 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 15380100.0 4243600.0 1307300.0 9829200.0 False True 4108889.240829197 1829311.707479439 7254637.650320664 1.0 0.44520832766722945 1.7655958155875326 21.970317011083065 -6.792562092023012 1.4860861254899949 0.6909609768844956 1.780647433437747 0.8095282379809298 0.2362534981738892 0.2315466036833796 1.0101310036303806 0.12511624391546486 0.29238992546411774 1.6122705010520638e-07 6.792562092023012 1.0896864565532511 QGDTGDWIGTFLGHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGDTGDWIGTFLGHK 15 0 Q9Y3F4;Q9Y3F4-2 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 0 18772500.0 6864200.0 5840900.0 6067400.0 False True 8999032.673007354 4969460.48764988 5439603.650610499 1.0 0.5522216296153478 0.6044653740314355 23.101338500448886 -10.235087497038641 4.9949031036522555 1.0000637225346396 0.5783435018243567 0.9886174241551718 0.021328419346478868 1.513725770833303e-05 2.3181162572406085e-06 0.02065426282784409 0.0068837177439845815 5.81985953611286e-11 10.235087497038641 -0.4217202207102829 QGDTGDWIGTFLGHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGDTGDWIGTFLGHK 15 0 Q9Y3F4;Q9Y3F4-2 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 0 13902200.0 5825200.0 2113200.0 5963800.0 False True 5640282.21455327 2957011.7801924194 4401701.869835017 1.0 0.5242666355528498 0.7804045440275275 22.427335919776315 -10.064222386201761 5.18720172897361 1.000004865113525 0.6523355897893914 0.7106875041046357 0.10456786326055982 5.883364838487241e-06 1.061345691642546e-06 0.1012488145718748 0.03374913274598647 8.625367613716957e-11 10.064222386201761 -0.3476692753241335 QGDTGDWIGTFLGHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGDTGDWIGTFLGHK 15 0 Q9Y3F4;Q9Y3F4-2 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 0 26261500.0 6864200.0 9846400.0 9550900.0 False True 9402080.238030123 9411353.490309445 7295174.126959938 1.0 1.0009862979303041 0.775910643418247 23.164548561971777 -6.9059141114737725 0.9231242300418919 1.0079008727894823 0.7492301292946842 0.9892858162490639 0.010958529786894294 0.10718191451421981 0.15388768408748893 0.008794449166640317 0.02364105772836942 1.2418978880387532e-07 6.9059141114737725 -0.258670743494798 QGDTGDWIGTFLGHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGDTGDWIGTFLGHK 15 0 Q9Y3F4;Q9Y3F4-2 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 0 11126900.0 5825200.0 2715700.0 2586000.0 False True 4843911.900115454 2701069.9850757564 3126720.643686951 1.0 0.5576216167373682 0.6454949446154102 22.20774119521059 -9.949851943997256 5.442899250774287 1.0000006362253306 0.6015582806789819 0.9648046569288745 0.03587413588762684 3.3368375070722985e-07 6.437944738354865e-08 0.034735049477412294 0.01157832757044368 1.1224010285548501e-10 9.949851943997256 -0.39844235554634877 QGELHLTPLHGILQLRPSFSYLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGELHLTPLHGILQLRPSFSYLDK 24 1 Q9NVU0-4;Q9NVU0;A0A0C4DH01;Q9NVU0-5;Q9NVU0-3;Q9NVU0-2 Q9NVU0-4 POLR3E DNA-directed RNA polymerase III subunit RPC5 0 16337800.0 2783300.0 9006100.0 4548400.0 False True 2314437.271096501 8957582.351729121 5499449.410574525 1.0 3.870306818678791 2.3761496927367896 21.142230030677506 -10.284430808674083 6.545796438166353 0.9999560459124754 3.123228255707786 0.7291734301005195 0.6099870923502217 0.00039130873719733425 4.277598062878632e-05 0.5906294336663225 0.1968724875061577 5.1948042997328724e-11 10.284430808674083 2.123272209795311 QGEVSK(ub)AASADSTTEGTPADGFTVLSTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGEVSKAASADSTTEGTPADGFTVLSTK 28 1 O75367-2;O75367-3;O75367 O75367-2 H2AFY Core histone macro-H2A.1 1 13372600.0 3599200.0 5231100.0 4542300.0 True False 3484945.3661024696 7319905.509826131 3352535.3639209247 1.0 2.100436230945177 0.9620051426144361 21.732704608295673 -6.6539316520636484 1.9949287302805276 1.7118533068491821 0.966825661127606 0.21002890191414714 0.4692294266361108 0.4989314923349338 3.810493086175705 0.190485937586403 0.5197247647854266 2.218545540234743e-07 6.6539316520636484 -0.7450276457215761 QGEYGLASICNGGGGASAMLIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGEYGLASICNGGGGASAMLIQK 23 0 P24752;A0A5F9ZHL1;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 9613200.0 1925700.0 4837400.0 2850100.0 False True 2524611.3485053265 4115678.776037513 2555198.992089687 1.0 1.630222718627231 1.0121157831293397 21.26762987847941 -10.155122846352969 4.64588750661992 0.9999698330812521 1.3211692507629555 0.2646955383655393 0.2523410997957283 176609865.9471718 5.7642031683699475 72080.54923538658 0.08638307033122607 6.99644063764483e-11 10.155122846352969 0.32119941768170346 QGEYGLASICNGGGGASAMLIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGEYGLASICNGGGGASAMLIQK 23 0 P24752;A0A5F9ZHL1;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 17036700.0 6798800.0 2250900.0 7987000.0 False True 6582975.815474965 3149696.1082884306 5894965.095136034 1.0 0.4784608354301205 0.8954863667094772 22.650308466919792 -9.942025051139098 6.823862074221264 1.000000018884515 0.6869736010697991 0.42897416368887586 0.17024996022458877 4.891962940733471e-08 7.559305118503784e-09 0.16484382498601635 0.05494793838685791 1.1428124127492893e-10 9.942025051139098 -0.31302641781471596 QGEYGLASICNGGGGASAMLIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGEYGLASICNGGGGASAMLIQK 23 0 P24752;A0A5F9ZHL1;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 11584900.0 1925700.0 3333500.0 6325700.0 False True 2637683.33008575 3186214.947589628 4831699.941880918 1.0 1.2079596179144239 1.8317968221468954 21.330839940002303 -6.951452234387146 0.5426672899381078 0.9909732126134257 2.077723984062121 0.9993103703824896 0.009281728922958622 0.08290780782034456 0.03358927918186743 0.010171859342880948 0.05168505417481511 1.118272810371632e-07 6.951452234387146 1.086750771448695 QGEYGLASICNGGGGASAMLIQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGEYGLASICNGGGGASAMLIQK 23 0 P24752;A0A5F9ZHL1;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 11398200.0 6798800.0 1801200.0 2798200.0 False True 5653503.43790856 1791496.5780897944 3383290.682585002 1.0 0.3168825486294451 0.5984414301225942 22.43071374235407 -10.410285439908478 6.000350095459358 1.000156955387253 0.45766198937628794 0.8318474913738081 0.1149459320344963 0.00024141925425258227 2.3726795235493754e-05 0.11132760153373437 0.03709864004032436 3.887895292088235e-11 10.410285439908478 -0.542494966010965 QGFDFLCMPVFHPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGFDFLCMPVFHPR 14 0 O14744-2;O14744;O14744-3;O14744-5;O14744-4;G3V580;G3V2L6;C9JSX3 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 9790200.0 1960400.0 4912100.0 2917700.0 False True 2570103.384540606 4179233.827215834 2615804.3925546734 1.0 1.6260956085869103 1.0177817780751401 21.293394963515354 -10.140897940702361 4.109594551586001 0.9999128420060518 1.321938693319116 0.2719052556620206 0.24834308162124835 31449189.65106453 19460406.66884508 24584.76069403266 0.08501444431721338 7.229396746221884e-11 10.140897940702361 0.32202585131306416 QGFDFLCMPVFHPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGFDFLCMPVFHPR 14 0 O14744-2;O14744;O14744-3;O14744-5;O14744-4;G3V580;G3V2L6;C9JSX3 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 4326790.0 2799100.0 1067800.0 459890.0 False True 2710244.1026498736 1494178.1085034385 339431.0125957319 1.0 0.55130757670224 0.12524001519415232 21.36999136548737 -7.8230134163756135 0.42057568037853765 1.0437877853398396 3.1714321735233557e-20 0.9974399376218129 0.018071198220093756 0.111127784132114 0.07972757506438174 0.034527595718777344 0.07890167397257722 1.5030955312248273e-08 7.8230134163756135 -1.0437877853398396 down QGFDFLCMPVFHPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGFDFLCMPVFHPR 14 0 O14744-2;O14744;O14744-3;O14744-5;O14744-4;G3V580;G3V2L6;C9JSX3 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 18510700.0 1960400.0 5951300.0 10599000.0 False True 2685212.8578179926 5688351.887682669 8095734.49325701 1.0 2.1183988714790494 3.014932119696319 21.356605025038245 -7.0893235124189555 0.15539544052981824 7.392972059960665e-12 5.053592485097059 0.9999982562772917 0.001088411743585764 0.07606717742640848 0.00530941686108446 0.05027305107400518 0.11695431232937606 8.140976246651844e-08 7.0893235124189555 5.053592485089665 QGFGNLPICMAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGFGNLPICMAK 12 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 5972040.0 912040.0 3120700.0 1939300.0 False True 1195693.2722079225 2655103.7243933277 1738639.8390791684 1.0 2.2205558784239976 1.4540851566962998 20.18941591586839 -10.180013397332473 4.736394034058844 0.999890583512699 1.8373205175647982 0.6140818530965009 0.312910361852097 0.0003616078656888227 6.260249111933213e-05 0.30301330517728114 0.10099138502345094 6.606730669214253e-11 10.180013397332473 0.8374299340520992 QGFHHLWLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGFHHLWLQR 10 0 Q969X6;H3BSH7;Q969X6-3;Q969X6-2;A0A0J9YWM9;A0A0J9YWK2;A0A0J9YXV4 Q969X6 CIRH1A Cirhin 0 9642800.0 1631900.0 1842800.0 6168100.0 False True 2139436.7033420797 1567861.4231781387 5529884.180593107 1.0 0.7328384245857493 2.584738390228935 21.02879956582457 -6.870295631571158 1.1325862623913578 0.8486418479283677 2.6937798162870195 0.96497452004 0.1529647208548531 0.13656880309105657 0.3272474003874579 0.10480011280411158 0.24823660676922746 1.3480449332963357e-07 6.870295631571158 1.8451379683586517 up QGFHHLWLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGFHHLWLQR 10 0 Q969X6;H3BSH7;Q969X6-3;Q969X6-2;A0A0J9YWM9;A0A0J9YWK2;A0A0J9YXV4 Q969X6 CIRH1A Cirhin 0 5695710.0 1966700.0 964910.0 2764100.0 False True 1904268.1850171506 1350203.5949391744 2040099.288777453 1.0 0.7090406727175426 1.0713298183675106 20.860805242270498 -6.692931486855738 1.8562077729553288 0.8180853381801807 1.0701155676459742 0.38404502047061795 0.1229838510158905 0.41042077402398597 2.74398133335526 0.05296144537252055 0.13739726823130163 2.0280026265960935e-07 6.692931486855738 0.25203022946579345 QGFHHLWLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGFHHLWLQR 10 0 Q969X6;H3BSH7;Q969X6-3;Q969X6-2;A0A0J9YWM9;A0A0J9YWK2;A0A0J9YXV4 Q969X6 CIRH1A Cirhin 0 5396600.0 1631900.0 2227200.0 1537500.0 False True 2235257.530439288 2128794.939634506 1174374.165806459 1.0 0.9523712192644491 0.5253865157880323 21.092009627347462 -6.92804255556237 0.7626971851844515 1.0069867941994972 0.4419464649162329 0.9961391261503723 0.013259585609391894 0.09366740242639628 0.08275620672936085 0.011942262752319998 0.03905899492227522 1.1802049842914767e-07 6.92804255556237 -0.5650403292832643 QGFHHLWLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGFHHLWLQR 10 0 Q969X6;H3BSH7;Q969X6-3;Q969X6-2;A0A0J9YWM9;A0A0J9YWK2;A0A0J9YXV4 Q969X6 CIRH1A Cirhin 0 4822100.0 1966700.0 1860700.0 994700.0 False True 1635398.1895826845 1850676.039779967 1202687.1710268403 1.0 1.1316363510541836 0.735409381450849 20.641210517704774 -6.81714812592139 1.3841191667424222 1.0711631070437384 0.7272739900369156 0.8777048613744344 0.05762005067016223 0.19721638509293343 0.7431536390469303 0.03271930070006755 0.07547786861919335 1.5235330298925917e-07 6.81714812592139 -0.3438891170068228 QGFYVALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGFYVALR 8 0 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R1V5 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 0 19298400.0 5055800.0 5453800.0 8788800.0 False True 6628202.760436849 4640114.298745891 7879419.284122611 1.0 0.7000561790961374 1.188771612593713 22.660186305408356 -6.740644907833569 1.6843086952672144 0.8216646317501671 1.1890987583758368 0.6078001623782903 0.12602239483646008 0.3166736727470309 1.7641975295231038 0.05918467855941435 0.14513268106354635 1.817000689734216e-07 6.740644907833569 0.36743412662566965 QGFYVALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGFYVALR 8 0 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R1V5 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 0 13417600.0 5273000.0 3242500.0 4902100.0 False True 5105611.501294271 4537247.159414124 3618092.9501522924 1.0 0.8886784978183186 0.7086502663265912 22.283652332983824 -6.963977003746418 0.37519669874975525 1.0130538481803204 0.577956905436625 0.9998904755675733 0.0012562567353789627 0.07830985891507913 0.016094681343064524 0.0023558174432973507 0.01524827709155651 1.0864831522794032e-07 6.963977003746418 -0.43509694274369537 QGFYVALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QGFYVALR 8 0 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R1V5 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 0 26544700.0 5858700.0 10390000.0 10296000.0 False True 8888076.228342306 8535823.322559483 8260991.087102885 1.0 0.960367924764241 0.9294464713027808 23.083439759338738 -6.973905641090615 0.13557248627017585 1.0441465174598454 0.8448641573775625 0.999999025112269 2.7920880051449226e-05 0.07505463719609942 0.00408953389825244 0.0018314953179900673 0.004110607775916284 1.0619262562356963e-07 6.973905641090615 -0.19928236008228295 QGFYVALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGFYVALR 8 0 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R1V5 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 0 14813900.0 5055800.0 4623200.0 5134900.0 False True 6925065.887857687 4418931.737122054 3922142.3765851 1.0 0.6381068149647713 0.5663689616963976 22.723396366931247 -13.999999999999998 0.2275175839223169 3.2585912106660855 0.5306552247015942 0.9995065054073126 0.0042159145161044945 13.21512622336574 0.15104693487553672 13.464808934375693 0.037821955602822005 1.0000000000000041e-14 13.999999999999998 -2.7279359859644914 QGFYVALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGFYVALR 8 0 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R1V5 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 0 11165500.0 5273000.0 2987700.0 2904800.0 False True 4384733.133507654 2971604.6670879847 3512180.249722295 1.0 0.6777161976812921 0.801002054807531 22.0640576084181 -10.06588644394403 5.607350127407218 1.0000015070950732 0.7393591265761811 0.8563079566730343 0.05033124041043628 9.482884077759011e-07 1.5793287130224e-07 0.04873329535226948 0.01624433799192484 8.592381592696894e-11 10.06588644394403 -0.2606423805188921 QGFYVALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QGFYVALR 8 0 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R1V5 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 0 27525000.0 5858700.0 12824000.0 8842300.0 False True 7584202.6422423795 12110333.126798019 7233092.129659692 1.0 1.596783959772655 0.9537050196118076 22.854566081431187 -6.662933877706629 1.9623082587409595 1.383209951825612 0.9563621889265775 0.24819391919356137 0.25391985752931534 0.4775456130003929 3.5379049748676485 0.10442785061818338 0.28161296121663343 2.1730320025971278e-07 6.662933877706629 -0.4268477628990345 QGGASQSDK(ub)TPEELFHPLGADSQV ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGGASQSDKTPEELFHPLGADSQV 24 1 P11166 P11166 SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 1 116143000.0 42769000.0 43339000.0 30035000.0 True False 56070573.17558515 36872990.134098865 26927266.316063926 1.0 0.6576174996219675 0.4802388274459246 25.7407404818907 -13.761034689322729 0.0859125421636533 2.7260799372847857 1.5454466672158077e-19 0.9998697013083195 0.002462475905983964 11.206950989450633 0.08134173606967948 3.6622278385419267 0.42230270520763025 1.7336655154869824e-14 13.761034689322729 -2.7260799372847857 QGGGGGGGSVPGIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGGGGGGGSVPGIER 15 0 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 12461220.0 2758500.0 705420.0 8997300.0 False True 2670932.927426559 987097.8847167017 6640637.216785709 1.0 0.3695704503024602 2.4862613166343928 21.348912316737085 -6.826890695696297 1.341755771588436 0.6623537172521404 2.539684461705595 0.8995150757518536 0.28128988455073806 0.18467523840050304 0.6513153146432715 0.16465502785535813 0.37899948358104 1.4897359709462866e-07 6.826890695696297 1.8773307444534546 up QGGLGPMNIPLVSDPK ddPTM_RPMI8226_Bortezomib_1h_R1 2 QGGLGPMNIPLVSDPK 16 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 75130470.0 5077870.0 39768900.0 30283700.0 False True 6657136.744163037 33835535.13795805 27150233.22576279 1.0 5.082595782282071 4.078364959164772 22.666470372265504 -9.92394122139752 5.994495412001908 0.9999987382283809 4.580480370724624 0.94428782013824 0.4099755167730389 6.952280877020021e-06 1.251211151130139e-06 0.39695722903907277 0.13231902906726933 1.1914032448882998e-10 9.92394122139752 3.580481632496243 QGGLGPMNIPLVSDPK ddPTM_RPMI8226_Bortezomib_2h_R1 2 QGGLGPMNIPLVSDPK 16 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 59170800.0 19567000.0 9374400.0 30229400.0 False True 18945856.29543428 13117646.80685018 22311413.27743902 1.0 0.6923755042949087 1.1776407954079013 24.17537901098656 -6.735415382263257 1.7034245632851859 0.8159941529197304 1.1776513066254644 0.584141826415393 0.12927320042941856 0.32621132184570095 1.8566813839207177 0.060080916350789236 0.14818490335257528 1.839012231255362e-07 6.735415382263257 0.3616571537057339 QGGLGPMNIPLVSDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QGGLGPMNIPLVSDPK 16 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 70441870.0 5077870.0 35096300.0 30267700.0 False True 6955295.763277015 33545629.418056082 23119092.642848898 1.0 4.823034211596334 3.3239553614548587 22.729680433788396 -9.785202543258466 7.1954473649814865 0.9999999997059542 4.073494786525598 0.8485933708841114 0.6119963778409699 5.2337477231663356e-08 1.2271476089368946e-08 0.5925629492441881 0.19752098160975157 1.6398248246710471e-10 9.785202543258466 3.0734947868196434 QGGLGPMNIPLVSDPK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGGLGPMNIPLVSDPKR 17 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 12127700.0 2731400.0 5414800.0 3981500.0 True False 3580891.8509152276 4606932.946725084 3569532.5732448287 1.0 1.2865322770213277 0.9968278076682222 21.771887516772228 -6.648720077171213 2.013447189080032 1.18612057768136 0.9980522195611311 0.18880470992846843 0.12233399213734779 0.511627716373709 3.9742735817273847 0.04930477614455764 0.13546447614354337 2.245328675398087e-07 6.648720077171213 -0.18806835812022882 QGGLGPMNIPLVSDPK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 QGGLGPMNIPLVSDPKR 17 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 15340400.0 5729700.0 4847900.0 4762800.0 True False 8692373.797179038 3982754.368184415 3821430.4923906 1.0 0.45818949588626184 0.4396302530881473 23.051318785230983 QGGLGPMNIPLVSDPK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QGGLGPMNIPLVSDPKR 17 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 14727000.0 5729700.0 4485800.0 4511500.0 True False 7417209.599272208 4236161.2866648855 3690453.291899126 1.0 0.571126004997964 0.49755278484529286 22.822445107323432 -13.999999999999998 0.24801204639783475 3.952994541562659 0.46740566542921413 0.9995389922234739 0.004757129538779714 13.92010963000636 0.15759133492411764 20.454517261751835 0.03433318408342979 1.0000000000000041e-14 13.999999999999998 -3.485588876133445 QGGLLVNFHPSILTCLLPQLTSPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QGGLLVNFHPSILTCLLPQLTSPR 24 0 Q86VP6;Q86VP6-2;H0YH27;Q86VP6-3 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 4898300000.0 1996000000.0 1391300000.0 1511000000.0 False True 3028077927.146162 1143011644.7234833 1212350187.7051725 1.0 0.3774710137003391 0.4003695469118136 31.49575518733523 -10.127625316418639 5.12566194084354 1.000020178889663 0.3889202803058034 0.9989479802587892 0.00934828704452121 26100056.29474704 1.9211061140741221 6356.342200843521 0.0032001673041336352 7.453747618263847e-11 10.127625316418639 -0.6110998985838596 QGGLLVNFHPSILTCLLPQLTSPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QGGLLVNFHPSILTCLLPQLTSPR 24 0 Q86VP6;Q86VP6-2;H0YH27;Q86VP6-3 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 4562600000.0 1996000000.0 1183100000.0 1383500000.0 False True 2583861347.042137 1117259444.9715152 1131717195.9087756 1.0 0.43239914798465967 0.4379945530762722 31.26688150942768 -9.842659122488486 5.766418890289733 1.0000001197249886 0.4351968505295081 0.9999263960840625 0.002284314568564673 3.5159177148446094e-09 7.058665778269391e-10 0.0022117785458844346 0.0007372593559994349 1.4366165905531668e-10 9.842659122488486 -0.5648032691954805 QGGPTYYIDTNALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGGPTYYIDTNALR 14 0 O96019;O96019-2;H7C5S0;C9JQT2 O96019 ACTL6A Actin-like protein 6A 0 24135300.0 5543200.0 6258100.0 12334000.0 False True 7267188.880425168 5324415.873882743 11057795.99608232 1.0 0.7326651283585788 1.5216056962366145 22.792965973005867 -6.815268873597585 1.3920768456826738 0.8551798844675079 1.5371621295461049 0.873183139687948 0.11666713570497224 0.19970269667913618 0.7616452720380108 0.06587668163689255 0.15206998938003585 1.5301398521579572e-07 6.815268873597585 0.681982245078597 QGGPTYYIDTNALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGGPTYYIDTNALR 14 0 O96019;O96019-2;H7C5S0;C9JQT2 O96019 ACTL6A Actin-like protein 6A 0 17568000.0 7122600.0 2669900.0 7775500.0 False True 6896496.961714122 3736004.993344569 5738863.290000034 1.0 0.5417250256304015 0.8321417847146619 22.71743230813164 -10.650039905222481 5.075434326871901 1.005241278664864 0.6869334051725394 0.6077537491780749 0.11856214541820952 0.007122645395044426 0.000491118288248988 0.1162826117312941 0.03826576789127829 2.2385154427453456e-11 10.650039905222481 -0.3183078734923245 QGGPTYYIDTNALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGGPTYYIDTNALR 14 0 O96019;O96019-2;H7C5S0;C9JQT2 O96019 ACTL6A Actin-like protein 6A 0 19300900.0 5543200.0 6749800.0 7007900.0 False True 7592670.839347433 6451571.517396279 5352778.352230943 1.0 0.8497104186266518 0.7049928102363249 22.856176034528758 -6.971586410622434 0.21698742785169906 1.0693288999637487 0.48130218497045607 0.9999922490724062 0.00033527043039199107 0.07579132331041263 0.007159467220784532 0.004102609681413817 0.014763011431238477 1.0676123509127195e-07 6.971586410622434 -0.5880267149932926 QGGSPDEPDSK(ub)ATR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QGGSPDEPDSKATR 14 1 V9GZ50;Q9ULX6-2;Q9ULX6 V9GZ50 AKAP8L A-kinase anchor protein 8-like 1 3025920.0 573070.0 651450.0 1801400.0 True False 869389.087028884 535193.6576979181 1445352.500418332 1.0 0.6155973955538474 1.6624921131202473 19.72964246079571 -6.807322738113065 1.4257913731295726 0.7898320404032295 1.6797008449567021 0.85271326086887 0.1659424227163715 0.21047456567984069 0.8437869335354309 0.09152907044594384 0.21199064319449956 1.5583939800271766e-07 6.807322738113065 0.8898688045534726 QGGSPDEPDSK(ub)ATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QGGSPDEPDSKATR 14 1 V9GZ50;Q9ULX6-2;Q9ULX6 V9GZ50 AKAP8L A-kinase anchor protein 8-like 1 3660070.0 573070.0 515100.0 2571900.0 True False 741850.4118985164 486434.23219070956 2103840.589922503 1.0 0.6557039322062853 2.8359364046700892 19.50076878288816 -6.866514033987041 1.152455269748988 0.808854619183997 2.9553983075795136 0.9610742223871153 0.18881214447652805 0.14023685364627872 0.35031258835948176 0.12740521552845757 0.29992514520264224 1.359834220280482e-07 6.866514033987041 2.1465436883955165 up QGHIYMEMNFTNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QGHIYMEMNFTNK 13 0 P63010;P63010-2;A0A087X253;P63010-3 P63010 AP2B1 AP-2 complex subunit beta 0 11558200.0 2895700.0 0.0 8662500.0 False True 4392988.604026625 0.0 6950353.078091376 1.0 0.0 1.5821468491224093 22.06677132622455 -6.735906813050236 1.7017871733721752 0.40218919973493195 1.582249186572212 0.5863569107526053 0.4202183733635721 0.3252866281982159 1.8480935375123837 0.19547924668426508 0.48184128199868487 1.8369324532801276e-07 6.735906813050236 1.1800599868372799 QGHIYMEMNFTNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QGHIYMEMNFTNK 13 0 P63010;P63010-2;A0A087X253;P63010-3 P63010 AP2B1 AP-2 complex subunit beta 0 12413500.0 2895700.0 5841300.0 3676500.0 False True 3748540.7327805203 5516226.520084621 3007414.724075617 1.0 1.4715663809775121 0.8022894610097606 21.837897648317 -6.717398331481807 1.7689816657104729 1.2876931734537704 0.8035027072695836 0.5000962040023982 0.19850264632253733 0.360385260611969 2.2026195561248167 0.0891542750011229 0.2244725668098184 1.9169097595824e-07 6.717398331481807 -0.4841904661841868 QGIEMHLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGIEMHLFR 9 0 Q13425 Q13425 SNTB2 Beta-2-syntrophin 0 7598300.0 3071200.0 1661700.0 2865400.0 False True 4026372.941543103 1413780.8372558665 2568915.894857652 1.0 0.3511301257439 0.638022342230702 21.941049376952545 -10.446954396704136 6.125511579689839 1.0002069990786184 0.4945762339874023 0.8053796933933359 0.11712325692812561 0.00033123020062565906 2.9905224992757734e-05 0.11344957855114694 0.03780136862801685 3.5731035572368916e-11 10.446954396704136 -0.5056307650912162 QGIEMHLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGIEMHLFR 9 0 Q13425 Q13425 SNTB2 Beta-2-syntrophin 0 5224370.0 2101000.0 467170.0 2656200.0 False True 2034304.9050292582 653713.4172593654 1960461.5357080686 1.0 0.32134485624216863 0.963700933356336 20.95610449827704 -10.90449046891845 10.592602559742703 1.0347979550464528 0.6425228947994263 0.2922542316756881 0.2622407703509322 0.1375176511173447 0.001239943175238808 0.16202634804168153 0.08463784468881366 1.2459755813081693e-11 10.90449046891845 -0.3922750602470265 QGIEMHLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGIEMHLFR 9 0 Q13425 Q13425 SNTB2 Beta-2-syntrophin 0 7216100.0 3071200.0 1521000.0 2623900.0 False True 4206705.636059278 1453797.1907256104 2004188.8609167908 1.0 0.3455904255015776 0.47642716993011613 22.004259438475437 -10.062576203198356 6.408753010606623 1.0000005786170185 0.41100879771859666 0.9643121210701245 0.053413877242822747 4.4155876604796776e-07 6.463468668536399e-08 0.05171781549916189 0.017239254751482844 8.658123908239413e-11 10.062576203198356 -0.5889917808984219 QGIEMHLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGIEMHLFR 9 0 Q13425 Q13425 SNTB2 Beta-2-syntrophin 0 2935920.0 2101000.0 834920.0 0.0 False True 1747074.5900814703 830422.1202413562 0.0 1.0 0.4753215031320624 0.0 20.736509773711315 -8.007427410241617 0.5781308900940415 1.0147347357048984 1.3657114115001598e-16 0.9896325922837763 0.041584905601438314 0.11189736824565086 0.1650466137080462 0.046452083008688506 0.07609780465642879 9.830431691304842e-09 8.007427410241617 -1.0147347357048981 QGILGAQPQLIFQPHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGILGAQPQLIFQPHR 16 0 Q8N163;Q8N163-2;H0YC69;E5RFJ3;H0YC58 Q8N163;H0YC58 CCAR2 Cell cycle and apoptosis regulator protein 2 0 25570000.0 5972100.0 8445900.0 11152000.0 False True 7829480.933898672 7185804.641860341 9998098.0175377 1.0 0.9177881270198311 1.2769809521151958 22.90048523457831 -6.84650267838597 1.2517807156795875 0.9562255652852235 1.290405254026806 0.9350694000358626 0.03915430953461097 0.16134642119839754 0.48826924353748147 0.02449568716793048 0.05657445180848313 1.4239584647659913e-07 6.84650267838597 0.33417968874158255 QGILGAQPQLIFQPHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGILGAQPQLIFQPHR 16 0 Q8N163;Q8N163-2;H0YC69;E5RFJ3;H0YC58 Q8N163;H0YC58 CCAR2 Cell cycle and apoptosis regulator protein 2 0 20765700.0 7642500.0 2944200.0 10179000.0 False True 7399893.020792994 4119834.413800171 7512814.536545599 1.0 0.5567424288734755 1.0152598848977015 22.819072983378323 -10.950530766505324 12.160781532091868 1.0535583124414474 0.7860011568857671 0.22506787238331194 0.18718896756972975 0.1048266970483718 0.000426427227046456 0.06989840200766709 0.06041497949927701 1.1206480338200676e-11 10.950530766505324 -0.26755715555568027 QGILGAQPQLIFQPHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGILGAQPQLIFQPHR 16 0 Q8N163;Q8N163-2;H0YC69;E5RFJ3;H0YC58 Q8N163;H0YC58 CCAR2 Cell cycle and apoptosis regulator protein 2 0 18162700.0 5972100.0 4783000.0 7407600.0 False True 8180146.759934113 4571671.244734123 5658077.444310842 1.0 0.5588739883159438 0.6916840993640577 22.9636952961012 -10.67827367854193 10.01441301283719 1.0002248059084564 0.6252790438400031 0.9138994363886254 0.05421950079170831 0.0002722949756410481 8.747871068740947e-06 0.052527888954028615 0.017499268633830504 2.0976176152695965e-11 10.67827367854193 -0.3749457620684533 QGILGAQPQLIFQPHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGILGAQPQLIFQPHR 16 0 Q8N163;Q8N163-2;H0YC69;E5RFJ3;H0YC58 Q8N163;H0YC58 CCAR2 Cell cycle and apoptosis regulator protein 2 0 14299900.0 7642500.0 2885700.0 3771700.0 False True 6355077.370155933 2870154.1613334008 4560345.031629571 1.0 0.45163166302458035 0.7175907964622742 22.5994782588126 -10.452055356183706 6.1801424016057895 1.0001706392071383 0.5846112297434322 0.7648446709230392 0.10857736155918907 0.0002553843651238232 2.2642963383486474e-05 0.10517214037502264 0.03504319275782336 3.5313815511344576e-11 10.452055356183706 -0.4155594094637062 QGILK(ub)NENGAPEDEENFEEAIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QGILKNENGAPEDEENFEEAIK 22 1 Q13564;Q13564-4;Q13564-3;Q13564-2 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 1 58501100.0 2066500.0 9471600.0 46963000.0 True False 3135031.5813865424 7781318.978051425 37680742.46538583 1.0 2.482054415097774 12.019254507388608 21.580048545710422 -6.934371635698589 0.7099888840118692 0.875803441477721 14.214629601600175 0.9973298821739847 0.25231159165510614 0.09043052778810771 0.0670194337912869 0.23616970689308225 0.8431738929084114 1.1631302863030505e-07 6.934371635698589 13.338826160122453 QGIPLCALINQHLSGLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGIPLCALINQHLSGLAR 18 0 Q9H2J4;H7BZP2 Q9H2J4 PDCL3 Phosducin-like protein 3 0 20642200.0 1945500.0 5441700.0 13255000.0 False True 2664803.9251606315 5201267.700704505 10124441.995294066 1.0 1.9518388019452417 3.7993196796585234 21.345597953488706 -6.960626651306083 0.42651032615609896 0.9238404753539013 4.897759377926543 0.9997927390137981 0.016730990446299197 0.07947802362018301 0.020309792958650017 0.02401477954628773 0.15352649140254385 1.0948972089574274e-07 6.960626651306083 3.973918902572642 QGK(ub)EGQENGHITTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGKEGQENGHITTK 14 1 P11717 P11717 IGF2R Cation-independent mannose-6-phosphate receptor 1 2682750.0 830610.0 1347100.0 505040.0 True False 690689.0172620501 1339842.9049215843 610641.5289588774 1.0 1.939864210137343 0.8841048774447179 19.397676757782975 -6.67192810614902 1.9309234428056614 1.5989325346490484 0.8883724087296956 0.2874410342379462 0.39906057507470355 0.456710571498339 3.284827970124182 0.16628586826162664 0.4430978660215527 2.1284913709199656e-07 6.67192810614902 -0.7105601259193528 QGLYELSASNFELHVAQGDHFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGLYELSASNFELHVAQGDHFIK 23 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 17821300.0 10462000.0 5561400.0 1797900.0 False True 13715783.314152114 4731660.798167409 1611870.5546745923 1.0 0.34497926146771535 0.11751939482825195 23.709333681670955 -10.24025835684905 0.2490899861245188 1.6461866611952933 1.400829787694724e-17 0.9991019590550718 0.011210798902083211 1.7962260018731937 0.1197128162945744 0.8661249638755909 0.10199984552400226 5.750977164633375e-11 10.24025835684905 -1.6461866611952933 QGLYELSASNFELHVAQGDHFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGLYELSASNFELHVAQGDHFIK 23 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 134219900.0 61977000.0 26913400.0 45329500.0 False True 60009574.05949462 37660060.97152686 33456344.094149157 1.0 0.6275675433754948 0.5575167732565458 25.838689354037047 -13.999999999999998 0.23495363281325787 3.4062425241715197 0.5250240317956788 0.9995169439859238 0.004268112534294142 13.450624671720384 0.15344332658520857 15.141222770716103 0.03527460325814672 1.0000000000000041e-14 13.999999999999998 -2.881218492375841 QGLYELSASNFELHVAQGDHFIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QGLYELSASNFELHVAQGDHFIK 23 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 510056000.0 89337000.0 247914000.0 172805000.0 False True 135530760.40954733 203671809.73907703 138650016.0068779 1.0 1.5027718366193832 1.023015111756953 27.014045085614345 -10.433729129405272 4.394639410330388 0.9991464667705199 1.2628934741883253 0.2859005092446322 0.19585986276580042 0.0016431186079014972 0.00021172377504176311 0.19024188808959275 0.06321349888989782 3.683586482550341e-11 10.433729129405272 0.26374700741780543 QGLYELSASNFELHVAQGDHFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGLYELSASNFELHVAQGDHFIK 23 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 22407400.0 10462000.0 3058900.0 8886500.0 False True 14330084.124919314 2923747.6835704 6787691.7232124265 1.0 0.20402864756991523 0.4736672628047566 23.772543743193847 -10.333325010442287 5.725344353188844 1.0001007760794278 0.33884795520121275 0.8890905063040863 0.1100795037126791 0.00014162279182402957 1.6490758717539716e-05 0.10660007739356094 0.03552800705316358 4.641677786638719e-11 10.333325010442287 -0.6612528208782151 QGLYELSASNFELHVAQGDHFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGLYELSASNFELHVAQGDHFIK 23 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 122346200.0 61977000.0 22406000.0 37963200.0 False True 51536621.54663454 22285294.430757232 45901129.59799554 1.0 0.4324166730757017 0.8906507299175686 25.619094629471324 -10.019699018712455 7.109357017179808 1.0000000363250132 0.6615337014966423 0.42110739863011215 0.18707327033801338 1.0788608638993557e-07 1.442682839896747e-08 0.18113293672758346 0.060377638378306904 9.556546587263799e-11 10.019699018712455 -0.33846633482837096 QGLYELSASNFELHVAQGDHFIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QGLYELSASNFELHVAQGDHFIK 23 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 306414000.0 89337000.0 135475000.0 81602000.0 False True 115648507.5955427 127935697.15790406 66751273.30722656 1.0 1.106245984646281 0.5771909616047589 26.785171407706795 -6.85446641980945 1.2133441141932115 1.0569923592033923 0.5541466940492908 0.946558642253191 0.05282573884979764 0.1526088379528772 0.43010493933882793 0.034024862588955374 0.0789942601019887 1.3980850128190672e-07 6.85446641980945 -0.5028456651541015 QGNLFDFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGNLFDFLR 9 0 Q9H857;Q9H857-2;Q9H857-4;Q9H857-3;H7C519 Q9H857 NT5DC2 5-nucleotidase domain-containing protein 2 0 3094080.0 705380.0 773700.0 1615000.0 False True 924760.0109096369 658266.975858979 1447895.2921739055 1.0 0.7118246551464494 1.565698424556322 19.818719487641193 -6.815658469156281 1.3904518626034688 0.8439563813198768 1.58267411328025 0.8741199450231445 0.12583780645025638 0.19918879977688148 0.7578275608062514 0.07113675095412733 0.16418657817958973 1.5287678145070867e-07 6.815658469156281 0.7387177319603732 QGNLFDFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGNLFDFLR 9 0 Q9H857;Q9H857-2;Q9H857-4;Q9H857-3;H7C519 Q9H857 NT5DC2 5-nucleotidase domain-containing protein 2 0 5682580.0 705380.0 2197700.0 2779500.0 False True 966178.0481777468 2100598.347177961 2123039.345599381 1.0 2.174131725658412 2.1973582918837 19.881929549164084 -10.887414774709775 0.6821859158160298 9.476073283049306e-14 2.1935030860165465 0.9999585015767014 0.0036013287523316293 2.695659437906333 0.34560457675056544 4.3264153381303885 0.003681503375886238 1.2959409860585303e-11 10.887414774709775 2.193503086016452 QGNLSSQVPLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGNLSSQVPLKR 12 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 9998000.0 3507300.0 3048600.0 3442100.0 True False 4804043.591218649 2913902.771627943 2629146.872274739 1.0 0.6065521089263823 0.547277896703639 22.195817811239838 -13.999999999999998 0.2665040348428535 3.980575712663644 0.5269262625415561 0.9995758672899102 0.004137568108498432 14.714584160943666 0.1633939079357473 23.712178090195618 0.02505562759839331 1.0000000000000041e-14 13.999999999999998 -3.453649450122088 QGNLSSQVPLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGNLSSQVPLKR 12 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 14913200.0 3302700.0 7945600.0 3664900.0 True False 2746341.3844179274 7902795.475721875 4431213.64541698 1.0 2.877572147643557 1.6134970220958718 21.389079540400783 -10.449240668702572 4.91291114870971 0.9975479793011041 2.245534584869851 0.5641766131863775 0.5160565090232079 0.013876438909164764 0.001555609941857925 0.5002636004979868 0.16655652209566774 3.5543429645408096e-11 10.449240668702572 1.2479866055687467 QGNMTAALQAALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGNMTAALQAALK 13 0 O15511;B1ALC0 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 0 21441300.0 4470600.0 5205700.0 11765000.0 False True 5860999.893351979 4429029.851659666 10547670.657848898 1.0 0.755678200349983 1.79963672577659 22.482715380409193 -6.845054584043293 1.2588241596200747 0.8699872152908731 1.8375301861966429 0.9327798367595447 0.11559232942657337 0.16298195097340704 0.49950630224660936 0.0719383495532251 0.16601668848740653 1.4287143801103126e-07 6.845054584043293 0.9675429709057698 QGNMTAALQAALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGNMTAALQAALK 13 0 O15511;B1ALC0 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 0 11952800.0 4930900.0 2213700.0 4808200.0 False True 4774371.278538206 3097641.954292995 3548788.177091915 1.0 0.6488062560650742 0.7432995823019584 22.18687933115196 -10.043834253287967 7.047847003667272 1.0000000554482806 0.6960529191835171 0.9324111508083893 0.038576738896452537 3.360954922366547e-08 4.5803950970179995e-09 0.037351773503224335 0.012450588941412632 9.039944136647932e-11 10.043834253287967 -0.30394713626476355 QGNMTAALQAALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGNMTAALQAALK 13 0 O15511;B1ALC0 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 0 12315100.0 4470600.0 3136100.0 4708400.0 False True 6123501.633422313 2997536.7323041335 3596372.892541874 1.0 0.48951350252663606 0.5873065947941827 22.545925441932084 -9.90922073418493 5.627593149784258 1.000000335578727 0.5384100486595204 0.9674324136641097 0.03992386274079591 1.6805348752550858e-07 3.26517850577526e-08 0.03865614210064427 0.012885371292120707 1.2324782555443682e-10 9.90922073418493 -0.46159028691920667 QGNMTAALQAALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGNMTAALQAALK 13 0 O15511;B1ALC0 O15511 ARPC5 Actin-related protein 2/3 complex subunit 5 0 9600400.0 4930900.0 2768400.0 1901100.0 False True 4100261.8259080066 2753486.0797156254 2298611.2203067495 1.0 0.671539086191371 0.5606010830290624 21.967284606586237 -13.999999999999842 0.15157531708878913 2.592221995179592 0.44073050847783685 0.9995610661845011 0.0039087138934581775 11.964005564663198 0.12269297294377488 5.608140543000521 0.10821301913723957 1.000000000000364e-14 13.999999999999842 -2.151491486701755 QGQDNLSSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGQDNLSSVK 10 0 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 22529060.0 724060.0 11120000.0 10685000.0 False True 949249.6718070147 9460939.345420497 9579418.69775738 1.0 9.966755455822726 10.091569143786762 19.856428069484785 -10.007945050489186 0.9645564877163969 6.2455329164918044e-18 10.059071014066548 0.9999694097205544 0.02354312074331226 1.3492458340318756 0.5563521958393056 4.267472166331385 0.016605033839624764 9.818721674447095e-11 10.007945050489186 10.059071014066548 QGQDNLSSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGQDNLSSVK 10 0 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 18247900.0 5725100.0 2637300.0 9885500.0 False True 5543359.8342612935 3690387.643337809 7296190.991356866 1.0 0.6657312088111251 1.3162037481785005 22.402329229168952 -6.767025056957711 1.5856794016533946 0.8075370383813142 1.3194685221213152 0.719040975192063 0.1407766595815194 0.2713052562067596 1.3457785001062186 0.06999490173010424 0.16708674843473126 1.7099166572735844e-07 6.767025056957711 0.511931483740001 QGQDNLSSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGQDNLSSVK 10 0 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 18614360.0 724060.0 8797100.0 9093200.0 False True 991764.5489857662 8408415.03388052 6945573.440332538 1.0 8.478237140538482 7.003248349051667 19.919638131007677 -10.066210244620738 10.229122820268579 0.9999999981083868 7.7407427447950745 0.9653342259382013 0.6021616525778517 2.7618674560021672e-08 0.0 0.583040517383678 0.19434683767989624 8.585977684366559e-11 10.066210244620738 6.740742746686688 QGQETAVAPSLVAPALNK(ub)PK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGQETAVAPSLVAPALNKPK 20 1 Q15691 Q15691 MAPRE1 Microtubule-associated protein RP/EB family member 1 1 8247700.0 3510800.0 1959900.0 2777000.0 True False 3399351.57571476 2742498.29074348 2049620.3917857474 1.0 0.8067710060754255 0.6029445163684745 21.69682814871185 -6.970450320184007 0.2472018548148875 1.0669528411462261 0.33681406920253476 0.9999856816158135 0.0006134157182266216 0.0761569290284123 0.00850605617922271 0.004633665584584566 0.019625429361743683 1.070408822118189e-07 6.970450320184007 -0.7301387719436914 QGQETAVAPSLVAPALNKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGQETAVAPSLVAPALNKPK 20 1 Q15691 Q15691 MAPRE1 Microtubule-associated protein RP/EB family member 1 0 15130100.0 3701700.0 1152400.0 10276000.0 False True 3584191.5597081343 1612559.3296866077 7584407.326607981 1.0 0.4499088016986237 2.11607197892782 21.773216314659322 -6.817735072787735 1.3816732440295831 0.7028138534642975 2.150703158286896 0.8790980557649622 0.241020584386952 0.19643417603435778 0.737457302736384 0.13710310512536558 0.3162030954195875 1.5214753732303055e-07 6.817735072787735 1.4478893048225987 up QGQHIK(ub)QLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGQHIKQLSR 10 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 3776980.0 758080.0 1338900.0 1680000.0 True False 734015.1653520127 1873529.7522712592 1239957.6010803243 1.0 2.5524401139215804 1.68928063017019 19.4854503450695 -10.497207998069722 7.177659163069995 0.9997241444956956 2.120860372045884 0.6921493170139954 0.3523833836391757 0.00155589363044589 0.00010898964266819772 0.34127058760321355 0.11373124802622887 3.182672868776034e-11 10.497207998069722 1.1211362275501884 QGQHIK(ub)QLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGQHIKQLSR 10 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 3271240.0 758080.0 1859200.0 653960.0 True False 630377.1086382484 1849184.120577693 790700.0124305945 1.0 2.933456966056925 1.2543285623722575 19.265855620503775 -6.611994461611073 2.1463753666624825 2.290004881889296 1.2604232068211376 0.05664578558454125 0.8331519387041587 0.6071328143862815 5.303187138457755 0.3202246292924501 0.924659462577878 2.443461713013915e-07 6.611994461611073 -1.0295816750681583 QGQHWLEK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGQHWLEKK 9 1 H0YNG3;P67812-2;P67812-4;P67812;P67812-3;H0YKT4 H0YNG3 SEC11A Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11A 1 14325600.0 1044400.0 2483200.0 10798000.0 True False 1011246.0936756564 3474754.709716933 7969679.866943657 1.0 3.436111873705209 7.881048853277277 19.94770269902947 -6.961799475420287 0.4092855610027973 0.7793258673765864 10.702598781968927 0.9998312226232435 0.037009995351174906 0.07906448417408769 0.018801676434409373 0.05722596859710675 0.3712051174173775 1.0919443979976498e-07 6.961799475420287 9.92327291459234 QGSATVGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGSATVGLK 9 0 P25786;P25786-2;F5GX11;B4DEV8;F5H112 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 10894200.0 2125500.0 4393900.0 4374800.0 False True 2786551.083371281 3738347.2472880543 3922137.662044829 1.0 1.341567814635306 1.4075240484375653 21.410049170632135 -12.408830655562015 0.2576586427414318 1.1154013572394733e-22 1.4338593658632017 0.99943576436818 0.004242493103691988 6.405760372964682 0.15220004359441763 3.374623643062445 0.02917410508322595 3.900940663953124e-13 12.408830655562015 1.4338593658632017 QGSATVGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGSATVGLK 9 0 P25786;P25786-2;F5GX11;B4DEV8;F5H112 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 8210900.0 2125500.0 2339100.0 3746300.0 False True 2911354.7894777316 2235750.827630691 2861501.0974703967 1.0 0.7679417279237764 0.9828761193285281 21.473259232155026 -10.457854230543546 7.733918265918376 1.000007990535174 0.8754089236659662 0.3094034690851426 0.08774659785288073 1.2090280141767488e-05 8.475597512612547e-07 0.0849657255324144 0.02832009268088055 3.484542528873967e-11 10.457854230543546 -0.12459906686920774 QGSATVGLK(ub)SK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGSATVGLKSK 11 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 1 22948100.0 5422100.0 9288300.0 8237700.0 True False 7108425.607691086 7902521.845509832 7385341.825598119 1.0 1.1117119713484178 1.0389560548551593 22.76109863275647 -10.757034661570817 6.224721259395891 0.9976847409248466 1.0753340131017874 0.5883927488890404 0.02970247852950437 0.000982659408747053 3.8355426463788804e-05 0.029611973291204893 0.009586433723821139 1.74970703680513e-11 10.757034661570817 0.07764927217694084 QGSATVGLK(ub)SK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGSATVGLKSK 11 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 1 40150300.0 8989300.0 13650000.0 17511000.0 True False 8703939.591994042 19100516.183809616 12924343.781260442 1.0 2.194467916732606 1.4848843612320524 23.053237113201828 -10.07092943038172 4.85362328686977 0.9999744451383493 1.8396761389901848 0.6512090794902683 0.2896862735049247 201066285.82878718 3.5995404159144413 58394.893948743724 0.09916731661929593 8.493184717494381e-11 10.07092943038172 0.8397016938518355 QGSATVGLK(ub)SK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGSATVGLKSK 11 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 1 22057100.0 5422100.0 7064000.0 9571000.0 True False 7426796.896742972 6751889.122475823 7310526.920932432 1.0 0.9091253223091196 0.9843445327202188 22.824308694279363 -10.117904800900824 4.36353603078514 1.0000075402923931 0.9467349275109762 0.400695111935788 0.030708114072843094 2.2529200574494915e-06 4.5541662635315316e-07 0.029737212605257215 0.0099110011980563 7.622460791234595e-11 10.117904800900824 -0.05327261278141693 QGSATVGLK(ub)SK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGSATVGLKSK 11 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 1 29872800.0 8989300.0 15395000.0 5488500.0 True False 7475001.243512296 15312064.07933177 6636119.974043243 1.0 2.0484363253613393 0.8877750996767879 22.833642388636104 -6.66878413702156 1.9412852722075482 1.6699318465746862 0.8924638957556587 0.27363352051843426 0.44548315076301725 0.464047616956419 3.370237692225358 0.1848008022572063 0.4945972178992198 2.143955974374164e-07 6.66878413702156 -0.7774679508190275 QGSATVGLK(ub)SK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QGSATVGLKSK 11 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 1 13852600.0 6087100.0 5026000.0 2739500.0 True False 7879870.944679456 4746298.681790922 2240939.1096437257 1.0 0.6023320324802598 0.2843877933250701 22.909740570960697 -7.803698514382331 0.25902358675331244 1.1478971292036544 1.8793474114501464e-11 0.9996736191752449 0.005288843127638881 0.1211219189563182 0.03914363997599723 0.04764348031201314 0.08539901729855338 1.5714533228378537e-08 7.803698514382331 -1.147897129184861 down QGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVKR 36 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 23783700.0 6084100.0 8546500.0 9153100.0 True False 7976314.018508204 7271395.513996072 8206025.014734967 1.0 0.9116235264965192 1.028799141519973 22.92729077745882 -6.704961371153217 1.813142713015535 0.9453891930224244 1.0284847461151985 0.44107780261603535 0.03727233511539069 0.3853368196342548 2.4660953792191767 0.01637866486052442 0.04186607553344922 1.9725981834379319e-07 6.704961371153217 0.08309555309277405 QGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVKR 36 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 44626000.0 17248000.0 10694000.0 16684000.0 True False 16700471.68107787 14964169.96847329 12313959.890728636 1.0 0.8960327740580009 0.7373420419424871 23.993385514356497 -6.964966515221971 0.3586327789888852 1.013889743666082 0.6140585141032854 0.999912443289885 0.0010105830479540585 0.07797239583732048 0.014900452907476006 0.0021350842174084252 0.013565351091105586 1.0840104896890191e-07 6.964966515221971 -0.3998312295627967 QGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 QGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVKR 36 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 79973000.0 20061000.0 25728000.0 34184000.0 True False 30434003.655550666 21136637.386218518 27427517.416620556 1.0 0.6945072894595496 0.9012129237757459 24.859180800037947 -10.06697859077459 5.000593019853876 1.000004365074677 0.7978601076216536 0.5604554344706281 0.08438722184264155 117097498.1107367 8.582288711341628 5885.3908621217815 0.028887990604676828 8.570800952921231e-11 10.06697859077459 -0.20214425745302345 QGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVKR 36 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 26849300.0 6084100.0 9982200.0 10783000.0 True False 8333556.186620297 9541153.397278905 8236277.482855963 1.0 1.1449077900977533 0.9883268677157877 22.99050083898171 -6.663561431308863 1.9603499846913044 1.093001699728319 0.9889763392363857 0.25079762152050766 0.06164654896369818 0.47606633683652894 3.5206347068785835 0.025374198913914254 0.06836404497008035 2.1698942485471883e-07 6.663561431308863 -0.10402536049193323 QGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVKR 36 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 40921600.0 17248000.0 15306000.0 8367600.0 True False 14342476.215956766 15223543.539996877 10117226.472588914 1.0 1.0614306282104813 0.7054030503695702 23.773790789790773 -6.862418361309313 1.1733715217544154 1.0335715751999999 0.687341918042604 0.9565177528209639 0.03240270751989815 0.1443360753678311 0.37623246833461416 0.021515324953289193 0.05037080626711827 1.3727189805136857e-07 6.862418361309313 -0.34622965715739584 QGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QGSGSSQPMEVQEGYGFGSGDDPYSSAEPHVSGVKR 36 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 98352000.0 20061000.0 21206000.0 57085000.0 True False 25969359.961429004 20025867.45842784 46696115.741563074 1.0 0.7711344248826795 1.798123473621163 24.630307122130397 -6.848213643787729 1.2435932773890925 0.8780257214192665 1.8378047019006725 0.937677092240725 0.10989721219813706 0.15943317017794326 0.47536532158150974 0.06917880039633638 0.15992024612367514 1.4183596121405324e-07 6.848213643787729 0.959778980481406 QGSK(ub)VQESTKGPDEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGSKVQESTKGPDEAK 16 2 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 4056910.0 1129900.0 1962800.0 964210.0 True False 1481309.841967166 1669957.890934474 864442.7985554175 1.0 1.1273521876535872 0.583566499097478 20.498442006518456 -6.844999982457219 1.2590029863417092 1.0677698871379029 0.5638396702482787 0.9327063089746871 0.0602404500158382 0.16304210106699024 0.49984575026083616 0.03748461979144928 0.08650753654132788 1.428894016229483e-07 6.844999982457219 -0.5039302168896241 QGSK(ub)VQESTKGPDEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QGSKVQESTKGPDEAK 16 2 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 9214000.0 3793300.0 2077900.0 3342800.0 True False 5754713.427376526 1707082.5102932001 2682094.114798711 1.0 0.2966407505493161 0.4660691012065619 22.456312656292155 -10.52681166463933 9.468842344597538 1.0000204595375126 0.38135492588421815 0.9467423361327726 0.06916883451193252 2.987577210434558e-05 1.4930689706065887e-06 0.06697463769508612 0.022324145345107634 2.97295499852771e-11 10.52681166463933 -0.6186655336532945 QGSK(ub)VQESTKGPDEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGSKVQESTKGPDEAK 16 2 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 3655870.0 1129900.0 1586700.0 939270.0 True False 1547654.5643993833 1516594.3474847635 717433.7708728667 1.0 0.979930781952836 0.46356195198590056 20.561652068041347 -6.915100948649986 0.8602678163275479 1.0135259519007338 0.3890009916616049 0.9927084509693939 0.021201126557717838 0.10114099580969257 0.12118305905584108 0.01780789506192069 0.051082306922470046 1.2159033397507276e-07 6.915100948649986 -0.624524960239129 down QGSK(ub)VQESTKGPDEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGSKVQESTKGPDEAK 16 2 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 4801390.0 2269000.0 1973200.0 559190.0 True False 1886774.0337433836 1962569.979950468 676114.0435975654 1.0 1.0401722436558576 0.35834394130183495 20.847490220710604 -6.8929106118917165 1.0049899597365237 1.0341202240817138 0.2962402656888486 0.9826973257983789 0.04109022659321534 0.11681395356320645 0.20829984683906239 0.03102763293767179 0.07820978186413746 1.279644658285375e-07 6.8929106118917165 -0.7378799583928652 down QGSK(ub)VQESTKGPDEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QGSKVQESTKGPDEAK 16 2 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 8860000.0 3793300.0 2815200.0 2251500.0 True False 4910501.627121717 2658531.645240314 1841750.102340883 1.0 0.5413971620652142 0.3750635357024456 22.227438978384605 -13.999999999999954 0.14109556858904984 3.19288048794169 0.1719088025767078 0.999598602060491 0.00529454598542002 11.935282877344129 0.1177663240483876 7.201671969250851 0.1817548536804686 1.0000000000001063e-14 13.999999999999954 -3.020971685364982 QGSPGSVSK(ub)QKPCDLPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGSPGSVSKQKPCDLPLR 18 2 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 16066500.0 4364100.0 7103500.0 4598900.0 True False 5721377.362004518 6043685.489226126 4123049.943763826 1.0 1.0563340095974172 0.7206393990273859 22.44793107194424 -6.86375361214712 1.1667068426843934 1.030923039455637 0.7031850847148111 0.9580371407431127 0.03006822030459886 0.14298027936773852 0.36773018779171385 0.020068810498832274 0.04706008172710242 1.368504997970559e-07 6.86375361214712 -0.3277379547408259 QGSPGSVSK(ub)QKPCDLPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QGSPGSVSKQKPCDLPLR 18 2 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 33429400.0 7992400.0 9114000.0 16323000.0 True False 12125055.122706907 7487535.491992984 13096751.895374935 1.0 0.6175258929727158 1.080139575683108 23.531487970280384 -6.687167284994353 1.8766687489342477 0.7595731107180478 1.0784789829101622 0.35707647454493496 0.16185489127114894 0.4228084259755746 2.884851185012861 0.06905590305893172 0.1804586662344883 2.055098844228772e-07 6.687167284994353 0.3189058721921144 QGSPGSVSK(ub)QKPCDLPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGSPGSVSKQKPCDLPLR 18 2 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 20051500.0 7538200.0 7136600.0 5376700.0 True False 6268347.2988824975 7098153.719295804 6500943.11094803 1.0 1.1323804155780013 1.0371064015720697 22.579653684121098 -10.028936351434586 4.581908031883169 0.9999974101760362 1.0847434085745942 0.5133527717174504 0.03889545336179763 1.19660056721438e-06 2.5354755165558275e-07 0.037661698641592176 0.012553453590207105 9.355427737302309e-11 10.028936351434586 0.08474599839855801 QGSPGSVSK(ub)QKPCDLPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QGSPGSVSKQKPCDLPLR 18 2 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 25842000.0 7992400.0 12681000.0 5168600.0 True False 10346319.353757303 11975291.202505121 4227967.8343144925 1.0 1.1574445745439175 0.4086446290466658 23.302614292372834 -6.851790932352653 1.2263628851255035 1.0841679403907973 0.37765173636160293 0.9428749190803172 0.07704463349830022 0.1555014028343725 0.44913366133550486 0.049134688916238 0.11384218156470462 1.406724552798011e-07 6.851790932352653 -0.7065162040291944 down QGTFHSQQALEYGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGTFHSQQALEYGTK 15 0 P53597;A0A494C0D1 P53597 SUCLG1 Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial 0 6368100.0 1736900.0 2182600.0 2448600.0 False True 2277092.7201635237 1856964.5877081638 2195242.360629734 1.0 0.8154980125599851 0.9640548850694531 21.11876160660313 -9.978719839067226 5.288304448287846 1.00000043795952 0.8897764488368141 0.4233020898370673 0.060648089240194075 3.131858615955669e-07 6.047797688534288e-08 0.05872249309557621 0.019574086633658085 1.050219701011242e-10 9.978719839067226 -0.11022398912270592 QGTFHSQQALEYGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGTFHSQQALEYGTK 15 0 P53597;A0A494C0D1 P53597 SUCLG1 Succinyl-CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial 0 5703900.0 1736900.0 1595800.0 2371200.0 False True 2379078.8679575925 1525292.27939509 1811171.3963969252 1.0 0.6411272446400792 0.7612910277126675 21.18197166812602 -10.912220158554103 11.009463561304592 1.0322818444901056 0.7012091361765825 0.8918190986484386 0.049056659015054675 0.025808319501477748 0.00020577261319375284 0.03153688625498463 0.015832968615490214 1.223995557241272e-11 10.912220158554103 -0.3310727083135231 QGTGLQGQAVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGTGLQGQAVFK 12 0 Q8WVC0;Q8WVC0-2 Q8WVC0 LEO1 RNA polymerase-associated protein LEO1 0 8710500.0 2393200.0 2735000.0 3582300.0 False True 3137508.3757817666 2326948.6609464977 3211637.9598480393 1.0 0.7416549638267329 1.0236268959912505 21.581187879760552 -6.665793397681767 1.9531247265613916 0.8345005643457648 1.022448726876756 0.260267308234129 0.1098479201464089 0.47080206803363145 3.4585279846208423 0.04535320540017181 0.12180378645284176 2.1587711342646577e-07 6.665793397681767 0.18794816253099111 QGTGLQGQAVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGTGLQGQAVFK 12 0 Q8WVC0;Q8WVC0-2 Q8WVC0 LEO1 RNA polymerase-associated protein LEO1 0 5831300.0 2393200.0 1342700.0 2095400.0 False True 3278030.7137982124 1283375.0742848632 1600509.6761176288 1.0 0.3915079467934066 0.48825341061650357 21.644397941283444 -10.81884501500795 7.350004878955211 1.0261090175512924 0.4398806787049582 0.978114765617895 0.03949617021591283 0.014796794395417246 0.00036469495261661915 0.03348676967567469 0.012747334123766982 1.517591847968806e-11 10.81884501500795 -0.5862283388463342 QGTGLQGQAVFK(ub)TK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGTGLQGQAVFKTK 14 1 Q8WVC0;Q8WVC0-2 Q8WVC0 LEO1 RNA polymerase-associated protein LEO1 1 8836000.0 2158700.0 5357700.0 1319600.0 True False 2830076.604880537 4558352.044151032 1183060.450497018 1.0 1.6106815046243066 0.4180312463828014 21.432409673966312 -6.767518633831593 1.5839334326908356 1.3513799934701474 0.4119404780304727 0.7209839197521186 0.2572136700761327 0.27046226224764464 1.3387480389679058 0.12802798360257367 0.3054610656707732 1.7079744361656903e-07 6.767518633831593 -0.9394395154396746 QGTGLQGQAVFK(ub)TK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGTGLQGQAVFKTK 14 1 Q8WVC0;Q8WVC0-2 Q8WVC0 LEO1 RNA polymerase-associated protein LEO1 1 21891000.0 10070000.0 8484300.0 3336700.0 True False 9750333.362039307 11872125.235040003 2462718.1711456613 1.0 1.2176122389067647 0.25257784320828364 23.217020114498137 -6.847463005871984 1.2471768873748357 1.1159271093146443 0.21582785247238434 0.9365415635694394 0.10411200590097147 0.1602730835671845 0.48099551267500007 0.0653598662443305 0.15103026003840078 1.4208132356000913e-07 6.847463005871984 -0.90009925684226 down QGTGLQGQAVFK(ub)TK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QGTGLQGQAVFKTK 14 1 Q8WVC0;Q8WVC0-2 Q8WVC0 LEO1 RNA polymerase-associated protein LEO1 1 21701100.0 8003100.0 7485700.0 6212300.0 True False 12141287.80498169 6149818.348958955 4984436.182052182 1.0 0.5065210913158342 0.4105360372074385 23.53341811803945 -13.999999999999938 0.2302015435341511 4.118094833850364 0.3639566871790546 0.9995100696185023 0.005716030629009628 13.297512430654406 0.15191522279644948 18.953705916627243 0.04976227948430046 1.0000000000001431e-14 13.999999999999938 -3.7541381466713095 QGTGLQGQAVFK(ub)TK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGTGLQGQAVFKTK 14 1 Q8WVC0;Q8WVC0-2 Q8WVC0 LEO1 RNA polymerase-associated protein LEO1 1 4802700.0 2158700.0 1405100.0 1238900.0 True False 2956829.726673994 1343018.035955659 946297.3359464208 1.0 0.4542087844423697 0.32003781868456405 21.495619735489203 -13.999999999999998 0.1970658627983855 4.000747821330365 0.23033796956070368 0.9994870473932651 0.006659989576979577 12.474412170912146 0.14077028704735114 14.411028316870084 0.08734065117216472 1.0000000000000041e-14 13.999999999999998 -3.7704098517696614 QGTPLIAFSLLPHEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGTPLIAFSLLPHEQK 16 0 Q2NL82;I3L4E8 Q2NL82 TSR1 Pre-rRNA-processing protein TSR1 homolog 0 31138100.0 7329300.0 8740800.0 15068000.0 False True 9608783.277042152 7436706.711371541 13508907.90246216 1.0 0.7739488441933893 1.4058916215477983 23.19592232901103 -6.809986027959904 1.4146990052988428 0.876803782134504 1.416932654545512 0.859768081107267 0.09790613928947046 0.20681803743794896 0.8158214405369659 0.05441876613703437 0.1258763009714142 1.5488664479499369e-07 6.809986027959904 0.540128872411008 QGTPLIAFSLLPHEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGTPLIAFSLLPHEQK 16 0 Q2NL82;I3L4E8 Q2NL82 TSR1 Pre-rRNA-processing protein TSR1 homolog 0 18740000.0 7474800.0 5713600.0 5551600.0 False True 7237516.565498649 7995070.27603038 4097469.415569957 1.0 1.1046703940054523 0.5661430103113899 22.787063314524204 -6.856290249298207 1.2043246670057852 1.056319806089619 0.5418514888891987 0.9489727593590306 0.052665085882691816 0.15067056230604123 0.41738124995573544 0.03415484348247282 0.07942424392925815 1.3922260342879269e-07 6.856290249298207 -0.5144683172004204 QGTPLIAFSLLPHEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QGTPLIAFSLLPHEQK 16 0 Q2NL82;I3L4E8 Q2NL82 TSR1 Pre-rRNA-processing protein TSR1 homolog 0 41418000.0 10045000.0 15570000.0 15803000.0 False True 15238999.387867324 12791411.851034766 12679530.123299044 1.0 0.839386597864081 0.8320447951060339 23.861264840956537 QGTPLIAFSLLPHEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGTPLIAFSLLPHEQK 16 0 Q2NL82;I3L4E8 Q2NL82 TSR1 Pre-rRNA-processing protein TSR1 homolog 0 53724300.0 7329300.0 18624000.0 27771000.0 False True 10039140.276885014 17801130.09866783 21212061.761698328 1.0 1.773172762577558 2.1129360858258766 23.25913239053392 -10.168031121895483 0.18947616601693776 2.52099488920445e-16 2.4421102189832413 0.9994729853349049 0.010690907774593236 1.7570372302206452 0.09073359638519592 1.0939489194817218 0.22143664610275635 6.79154962076853e-11 10.168031121895483 2.442110218983241 QGTYGGYFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGTYGGYFR 9 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 6550000.0 1243600.0 2109500.0 3196900.0 False True 1630371.643039533 1794770.8227665967 2866115.4548301864 1.0 1.100835401810946 1.757952223388057 20.636769433446663 -6.934112645728847 0.7122244910948295 0.9913689627173431 1.9081633947587122 0.9972866312100781 0.017505667687503865 0.0905577690299244 0.06762599981785866 0.016358435011010412 0.05817184569466234 1.163824121775284e-07 6.934112645728847 0.9167944320413691 QGVLLLNAVLTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QGVLLLNAVLTVR 13 0 P13051;P13051-2;F5GYA2 P13051 UNG Uracil-DNA glycosylase 0 27935800.0 6740800.0 9691000.0 11504000.0 False True 10226286.41849042 7961565.333871414 9230229.357617674 1.0 0.7785392475880488 0.9025983607234247 23.285779003010777 -10.122131023606778 4.785233212188146 1.0000100407292378 0.8405688041990472 0.6877004715777956 0.050646920858536705 5.425631519451542e-06 9.953093974793752e-07 0.0490417578855242 0.016346223417835933 7.54864455983414e-11 10.122131023606778 -0.1594412365301906 QGVLLLNAVLTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QGVLLLNAVLTVR 13 0 P13051;P13051-2;F5GYA2 P13051 UNG Uracil-DNA glycosylase 0 16515200.0 6740800.0 4294300.0 5480100.0 False True 8726098.481032897 4055318.430006912 4482778.0305744 1.0 0.4647344330139727 0.5137207699773495 23.056905325103227 -10.29434587814485 8.725288786640972 1.0000003557878652 0.4892276024377717 0.9931487362915974 0.01999858832138533 1.3840699199044174e-07 1.1210515661334732e-08 0.019363563439456045 0.006454516626365302 5.077548984509025e-11 10.29434587814485 -0.5107727533500934 QGVQVQVSTSNISSLEGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGVQVQVSTSNISSLEGAR 19 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 11039200.0 4237300.0 4765900.0 2036000.0 False True 5555141.334071577 4054846.297332692 1825334.250691063 1.0 0.7299267567618732 0.32858466435330197 22.405392186495753 -6.965412225901293 0.3509086893874369 1.038381628376839 0.006568228899668884 0.9999213886924065 0.0024457171495857358 0.07782139101478572 0.014368480604829724 0.0054964453499847295 0.03447576065091948 1.082898554748906e-07 6.965412225901293 -1.03181339947717 down QGVQVQVSTSNISSLEGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGVQVQVSTSNISSLEGAR 19 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 13902300.0 5607300.0 3709500.0 4585500.0 False True 5429299.330780837 5190722.694786951 3384419.9879487087 1.0 0.9560575644372192 0.6233622023308051 22.37233459475125 -6.931136363647905 0.737405918312074 1.004852062498253 0.5530424162609013 0.9967568646774736 0.009575957361543477 0.09205218913230925 0.07482130955065984 0.008783856799088647 0.02991733594333833 1.1718273669880817e-07 6.931136363647905 -0.45180964623735176 QGVQVQVSTSNISSLEGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QGVQVQVSTSNISSLEGAR 19 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 44575000.0 12971000.0 18515000.0 13089000.0 False True 19677955.307120703 15210853.59164474 10501953.412887495 1.0 0.7729895385086331 0.5336912930728752 24.230076985420755 -6.970458741514039 0.24698309040951122 1.0788168820101691 0.22088195281376724 0.9999857421064862 0.000718888991353297 0.07615413835403881 0.008495816317908376 0.00544823457130881 0.023049281616493385 1.0703880662050015e-07 6.970458741514039 -0.8579349291964019 QGVQVQVSTSNISSLEGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGVQVQVSTSNISSLEGAR 19 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 12138300.0 4237300.0 3536000.0 4365000.0 False True 5803944.318726887 3379767.828011678 3334076.8999968735 1.0 0.5823225796819913 0.574450187132087 22.468602248018644 QGVQVQVSTSNISSLEGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGVQVQVSTSNISSLEGAR 19 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 12300900.0 5607300.0 4000200.0 2693400.0 False True 4662718.395508715 3978650.128622463 3256577.487125456 1.0 0.8532898174710338 0.6984289444248444 22.152739870185528 -6.9704414657212155 0.24741931897550573 1.0507324454631972 0.49646548834218174 0.9999856206780249 0.0004668774508009026 0.07615975663124648 0.008516244133927098 0.0035152643116918214 0.014905356309093773 1.0704306460006029e-07 6.9704414657212155 -0.5542669571210155 QGYNMLNLLIHR ddPTM_RPMI8226_Bortezomib_1h_R1 2 QGYNMLNLLIHR 12 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 51158600.0 15021600.0 14205100.0 21931900.0 False True 19693463.06938132 12085754.451046105 19662597.373640154 1.0 0.613693711891465 0.9984326933443639 24.231213493770632 -10.93710816983817 10.077294908819761 1.0450692882526216 0.8060632026179145 0.25305521541248444 0.15706903145295387 0.09380097923439838 0.0005854060295920525 0.08969464349509093 0.050693811918518274 1.155824324876259e-11 10.93710816983817 -0.23900608563470704 QGYNMLNLLIHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGYNMLNLLIHR 12 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 26247600.0 9351500.0 6440100.0 10456000.0 False True 9054641.7512523 9011665.514677837 7717259.926723736 1.0 0.9952536789687435 0.8522987588831334 23.11022613110524 -6.913959064283268 0.8683347046916967 1.0038914125725067 0.8321696138534715 0.9923319187790071 0.006001503676416128 0.10185792037273644 0.12499519165312982 0.005011797155595638 0.014245539346435966 1.2191045038265423e-07 6.913959064283268 -0.17172179871903515 QGYNMLNLLIHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QGYNMLNLLIHR 12 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 22963000.0 10399000.0 0.0 12564000.0 False True 15776043.268733948 0.0 10080719.893003166 1.0 0.0 0.6389891128773608 23.911232077905 -10.253018720071735 7.311267217035395 1.0000023520787589 0.3194945564386805 0.6019457163082099 0.26086621295720297 1.0001603138324462e-05 1.021867158551134e-06 0.2525834973894836 0.08419420819762033 5.5844612264467786e-11 10.253018720071735 -0.6805077956400784 QGYNMLNLLIHR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QGYNMLNLLIHR 12 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 67403130.0 15021600.0 19476630.0 32904900.0 False True 20575491.463476192 18616088.085997485 25133440.317687757 1.0 0.9047700327860032 1.2215232069815896 24.294423555293523 -6.826091133049581 1.3452409966398333 0.9489619319630279 1.2293886590124976 0.8978371381360046 0.042413496155186976 0.1856842357088009 0.6585340282650565 0.024764098361467975 0.057008353687799 1.4924811920736435e-07 6.826091133049581 0.2804267270494697 QGYNMLNLLIHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QGYNMLNLLIHR 12 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 20997600.0 9351500.0 4075700.0 7570400.0 False True 7776186.59169293 4053743.395136887 9153335.638425251 1.0 0.5213022279413126 1.177098251243545 22.890631406539516 -6.710969857506979 1.7914699904391833 0.7060076802667232 1.1756219449044611 0.46985808558891196 0.20168936585032587 0.37311730077613015 2.3347976566263067 0.08956723023813629 0.22729929996202702 1.9454951052991755e-07 6.710969857506979 0.4696142646377379 QGYNMLNLLIHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QGYNMLNLLIHR 12 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 34852000.0 10399000.0 12927000.0 11526000.0 False True 13461710.494935472 12207601.086253725 9428386.26674706 1.0 0.9068387773490179 0.7003854577242752 23.68235839999745 -6.957990235738134 0.4628949050876879 1.0058468994729455 0.5930143651508581 0.9996882226178363 0.002210641025436462 0.08042709563422121 0.023844835526746943 0.002817922258394669 0.017049980538335716 1.1015640757763874e-07 6.957990235738134 -0.41283253432208733 QGYSLSGYYTHPFQGYEHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGYSLSGYYTHPFQGYEHR 19 0 P55265;P55265-3;P55265-2 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 6632900.0 2082800.0 2764100.0 1786000.0 False True 2730570.969863889 2351707.0543774106 1601201.8525217301 1.0 0.8612510278370961 0.5863981819895878 21.380771223495845 -6.960231770628114 0.43215554789892746 1.010671226154935 0.42640024202879223 0.9997786964342589 0.0025568181310861933 0.07961845131253548 0.020826217796106394 0.0035916727702695363 0.022810106541233173 1.09589319299091e-07 6.960231770628114 -0.5842709841261429 QGYSLSGYYTHPFQGYEHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QGYSLSGYYTHPFQGYEHR 19 0 P55265;P55265-3;P55265-2 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 5288810.0 1394200.0 646110.0 3248500.0 False True 1349941.884146496 904105.0924191385 2397620.3970889463 1.0 0.6697363071972251 1.7760915675305886 20.36446586900148 -6.8266957673662345 1.3425325373594272 0.823080801436502 1.8039173309550363 0.8991092565616174 0.14729614018662926 0.18493101036408838 0.653023219370503 0.08616968244879741 0.1983565715735587 1.490404772730524e-07 6.8266957673662345 0.9808365295185343 QGYTLSCNLLHHLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGYTLSCNLLHHLLR 15 0 Q14997;Q14997-2 Q14997 PSME4 Proteasome activator complex subunit 4 0 11026800.0 1694300.0 4099200.0 5233300.0 False True 2221243.707624541 3487615.338556452 4691808.317358325 1.0 1.570118274993879 2.1122438304511277 21.082936258693838 -6.971736154294633 0.21266886691799497 0.7256538816536297 2.9718879848052966 0.9999929433617684 0.0012063245782500452 0.07574326376933584 0.0069775220753922704 0.015895395417747853 0.05583562307045455 1.0672443042470173e-07 6.971736154294633 2.246234103151667 QGYTLSCNLLHHLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGYTLSCNLLHHLLR 15 0 Q14997;Q14997-2 Q14997 PSME4 Proteasome activator complex subunit 4 0 15202500.0 1694300.0 3866000.0 9642200.0 False True 2320728.4967358834 3695187.336847612 7364910.947342471 1.0 1.5922531834486078 3.173534068160604 21.14614632021673 -6.954037483269743 0.5126071681698346 0.9715105586312951 3.8639588898282318 0.9994812199057727 0.02089656889556719 0.08190388050868083 0.029557799868815536 0.023961843850906574 0.13053094856079273 1.1116357796154114e-07 6.954037483269743 2.8924483311969365 QGYVLSSIEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QGYVLSSIEGR 11 0 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 11337100.0 1699000.0 4409500.0 5228600.0 False True 2227405.453139406 3751619.788096374 4687594.628272746 1.0 1.6843003516978334 2.104508912674986 21.08693276417718 -8.909116633115557 0.13704614234568577 2.1605426053623456e-16 2.937607305650408 0.9998919924960599 0.004730634968220139 0.40785679507129324 0.04288066144280941 0.5083098274832297 0.34499258448523523 1.2327737179278138e-09 8.909116633115557 2.937607305650408 QGYVLSSIEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QGYVLSSIEGR 11 0 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 10973300.0 1699000.0 5633400.0 3640900.0 False True 2327166.2137486083 5384497.760837384 2780994.4066892574 1.0 2.313757276565138 1.1950132269278786 21.150142825700073 -6.606991798368955 2.165440037077792 1.8795007810643138 1.1989467118265271 0.041056342351986186 0.5668399778268183 0.6208910035036109 5.512888088661887 0.21653211195258004 0.62941236891955 2.4717708238521467e-07 6.606991798368955 -0.6805540692377867 QHALCVGVMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QHALCVGVMK 10 0 Q9ULC4;Q9ULC4-3;A0A3B3IRV3;Q9ULC4-2 Q9ULC4 MCTS1 Malignant T-cell-amplified sequence 1 0 17186400.0 6734400.0 5666300.0 4785700.0 False True 8828863.61602236 4820910.127064407 4290521.671675946 1.0 0.5460397098348605 0.4859653357754484 23.07379632644665 -13.999999999999998 0.28505300869644906 4.80479692973605 0.4687632989591131 0.9996164070039962 0.00449434569437722 15.678267994086456 0.16921290536309275 34.87976577196726 0.02320752339321505 1.0000000000000041e-14 13.999999999999998 -4.336033630776937 QHALCVGVMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QHALCVGVMK 10 0 Q9ULC4;Q9ULC4-3;A0A3B3IRV3;Q9ULC4-2 Q9ULC4 MCTS1 Malignant T-cell-amplified sequence 1 0 14238900.0 6734400.0 3423700.0 4080800.0 False True 9224289.67031701 3272429.6133381175 3116999.0867141443 1.0 0.3547622343071599 0.3379120992637933 23.137006387969542 QHATNVGIMFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QHATNVGIMFR 11 0 P16930;P16930-2;H0YLC7 P16930 FAH Fumarylacetoacetase 0 33821300.0 10991000.0 4969100.0 17861200.0 False True 14409307.4369954 4227729.64940009 16013094.360728495 1.0 0.29340269599255964 1.1113021518033148 23.780497660291623 -6.678200452221555 1.9084639139380226 0.5521958333370237 1.1081307856451252 0.3157825919809024 0.29959339963543813 0.4425595589344333 3.1149316868375996 0.12604112070703094 0.3331710455130827 2.0979713240454432e-07 6.678200452221555 0.5559349523081015 QHATNVGIMFR ddPTM_RPMI8226_Bortezomib_2h_R1 2 QHATNVGIMFR 11 0 P16930;P16930-2;H0YLC7 P16930 FAH Fumarylacetoacetase 0 22667970.0 10869200.0 2818470.0 8980300.0 False True 10524163.195499286 3943899.769126881 6628090.026774781 1.0 0.3747471125128039 0.6297973438505133 23.32720218950339 -10.33194255460666 5.794492336982209 1.0000669789177399 0.5022722281816899 0.8354653399862554 0.10412382092603892 9.010805221892227e-05 1.0388731158600464e-05 0.10083094201454994 0.03360581869916842 4.65647682021867e-11 10.33194255460666 -0.49779475073604995 QHATNVGIMFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QHATNVGIMFR 11 0 P16930;P16930-2;H0YLC7 P16930 FAH Fumarylacetoacetase 0 12323200.0 2301800.0 4472100.0 5549300.0 False True 3491998.884120761 3674018.8143232195 4452478.422655403 1.0 1.052124853484393 1.2750515021359974 21.735621667273858 -6.943340614934372 0.6277188018951553 0.997567910916103 1.3415760276656465 0.9985695035074478 0.0045116953077247 0.08627518775724546 0.04791443208580482 0.004512151490559744 0.01892272941567244 1.1393558461045555e-07 6.943340614934372 0.34400811674954357 QHATNVGIMFR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QHATNVGIMFR 11 0 P16930;P16930-2;H0YLC7 P16930 FAH Fumarylacetoacetase 0 27580800.0 12320800.0 3532800.0 11727200.0 False True 16876132.71710056 3376709.214592662 8957476.889265371 1.0 0.2000878560981597 0.5307778173721502 24.008481002552802 -10.560291818898571 6.346850467147545 1.0010273431284242 0.3654328367608373 0.8307856846249664 0.13500361136366773 0.001965283764659836 0.00013615398196575282 0.13089868193872156 0.04357222820744528 2.7523786544652028e-11 10.560291818898571 -0.635594506367587 QHATNVGIMFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QHATNVGIMFR 11 0 P16930;P16930-2;H0YLC7 P16930 FAH Fumarylacetoacetase 0 13093400.0 9692300.0 1850000.0 1551100.0 False True 8059576.891692821 1840033.682803751 1875427.8385239085 1.0 0.22830400497826545 0.232695569969306 22.94227267206266 -10.03383751653114 5.011249734687424 1.000011003233642 0.23049978746826058 0.9999755726526088 0.0017928489207835168 2287273.2545055863 1526573.7243951424 254.7931348364885 0.0006137399326502671 9.250441978529675e-11 10.03383751653114 -0.7695112157653814 QHATNVGIMFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QHATNVGIMFR 11 0 P16930;P16930-2;H0YLC7 P16930 FAH Fumarylacetoacetase 0 28298900.0 2301800.0 15215000.0 10782100.0 False True 2979725.4752613194 14368271.87494008 8819868.433688482 1.0 4.822011958561382 2.9599600724677453 21.506747989366307 -9.597404351242343 12.708622721303648 1.0000275141309307 3.8909860155145637 0.7626963130838204 0.7601794994187147 0.0 0.0 0.736040657204365 0.2453468784230824 2.526944181530514e-10 9.597404351242343 2.8909585013836328 QHFISFDTDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QHFISFDTDR 10 0 C9J0K6;P30626-3;P30626-2;P30626 C9J0K6 SRI Sorcin 0 29891300.0 2712400.0 7495600.0 19683300.0 False True 3555982.6669189665 6377285.697619956 17646660.931545902 1.0 1.7933961706133594 4.962527263057672 21.761816861317786 -6.944906852569482 0.6122132972589869 0.96505036131527 5.956539787489656 0.998738532665915 0.06080073044301463 0.08559766491443217 0.044939391364461644 0.061673732362355564 0.2674390217531698 1.1352542787695253e-07 6.944906852569482 4.991489426174386 QHFISFDTDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QHFISFDTDR 10 0 C9J0K6;P30626-3;P30626-2;P30626 C9J0K6 SRI Sorcin 0 15573500.0 5072300.0 0.0 10501200.0 False True 4911282.612936641 0.0 7750620.690752794 1.0 0.0 1.578125573620453 22.22766841212842 -6.735475082511725 1.7030967279189348 0.40189259570380087 1.5781900675420877 0.5844552907218774 0.4202298047429303 0.32610495461907024 1.8553657280932396 0.19533665092344496 0.4817708851465856 1.8387594489936471e-07 6.735475082511725 1.1762974718382868 QHFISFDTDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QHFISFDTDR 10 0 C9J0K6;P30626-3;P30626-2;P30626 C9J0K6 SRI Sorcin 0 13227700.0 2140900.0 6984900.0 4101900.0 False True 3247901.8207551227 5738390.021727207 3291157.6670733597 1.0 1.7667991024411744 1.013318089248209 21.631076591979497 -10.376430747305697 4.551072642223133 0.9994334726445169 1.390058595845408 0.2632524923809342 0.30760733553544745 0.0017707112358827778 0.00024261499047562073 0.29826143121292725 0.09927984064132535 4.2030954498703615e-11 10.376430747305697 0.39062512320089104 QHFISFDTDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QHFISFDTDR 10 0 C9J0K6;P30626-3;P30626-2;P30626 C9J0K6 SRI Sorcin 0 26354100.0 2712400.0 7249800.0 16391900.0 False True 3715247.579853869 6929479.864117386 12520470.821777495 1.0 1.8651461888281322 3.3700232764218527 21.825026922840678 -6.962680174753719 0.39585905149370965 0.9134004361620036 4.37635149924641 0.9998570421126943 0.011708243792974157 0.0787573191852128 0.017693299190432256 0.019380499881162902 0.1262842978705267 1.0897323038556586e-07 6.962680174753719 3.4629510630844065 QHFISFDTDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QHFISFDTDR 10 0 C9J0K6;P30626-3;P30626-2;P30626 C9J0K6 SRI Sorcin 0 12849300.0 5072300.0 5236700.0 2540300.0 False True 4217842.190990111 5208488.857696436 3071464.9849798772 1.0 1.2348704910824977 0.7282076583000064 22.008073687562696 -6.780649190264011 1.533179526263694 1.132881117028263 0.7241022654884137 0.7696941200581132 0.0993527689661064 0.24958951313317754 1.158851177798489 0.051034969761513 0.12036406798140167 1.6571079838949683e-07 6.780649190264011 -0.4087788515398494 QHFPATPLLDYALEVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QHFPATPLLDYALEVEK 17 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 7176000.0 2232100.0 1550000.0 3393900.0 False True 2161243.20728977 2168923.083143216 2504935.7751824474 1.0 1.0035534528587724 1.1590254010901777 21.043429998859857 -6.911824779909793 0.8832070660468231 0.9954595989304859 1.1799226199274666 0.9915923321432106 0.006798318453768927 0.10322400552426374 0.13231011657329292 0.005616578975401561 0.01570769951026495 1.2251103815820504e-07 6.911824779909793 0.18446302099698075 QHGCTANDANTK(ub)YNSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QHGCTANDANTKYNSR 16 1 Q8N6H7;G5E9L0;Q8N6H7-2;E9PIY6;E9PK28;E9PJT7;H0YDX1;H0YF45;E9PN48 Q8N6H7;E9PN48 ARFGAP2 ADP-ribosylation factor GTPase-activating protein 2 1 4031000.0 1553300.0 1529000.0 948700.0 True False 1503991.3417334312 2139537.673629663 700207.0096100606 1.0 1.4225731320791584 0.4655658514649654 20.520364830971243 -6.786682939016069 1.5096807996659922 1.2371947379110435 0.4563122919756326 0.790379641804777 0.17928461310813684 0.24032133735268246 1.0820993270032695 0.09349696053985924 0.2194285798693031 1.634244608932243e-07 6.786682939016069 -0.7808824459354109 down QHGCTANDANTK(ub)YNSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QHGCTANDANTKYNSR 16 1 Q8N6H7;G5E9L0;Q8N6H7-2;E9PIY6;E9PK28;E9PJT7;H0YDX1;H0YF45;E9PN48 Q8N6H7;E9PN48 ARFGAP2 ADP-ribosylation factor GTPase-activating protein 2 1 13680000.0 1881000.0 1751000.0 10048000.0 True False 2853614.519520007 1438520.3693745565 8062008.395805145 1.0 0.5041046572809431 2.825191819237455 21.44435903085908 -6.850835286804635 1.2310796242463107 0.7351791708688277 2.9194735467047055 0.9415116442356444 0.24136868232019618 0.156537520234698 0.4561166135765291 0.15338748323744766 0.3551365410137264 1.4098233953270937e-07 6.850835286804635 2.184294375835878 up QHGCTANDANTK(ub)YNSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QHGCTANDANTKYNSR 16 1 Q8N6H7;G5E9L0;Q8N6H7-2;E9PIY6;E9PK28;E9PJT7;H0YDX1;H0YF45;E9PN48 Q8N6H7;E9PN48 ARFGAP2 ADP-ribosylation factor GTPase-activating protein 2 1 4725680.0 1553300.0 933880.0 2238500.0 True False 1291637.7728574686 928849.0030793343 2706560.0003454117 1.0 0.7191249920048848 2.09544816450957 20.30077010640552 -6.853560862272406 1.2178817579496932 0.8495321915938846 2.1543322852282247 0.9453097344053952 0.13886089079727176 0.1535910147996305 0.4366146867924848 0.08913262493157853 0.2067710285736093 1.401003233802565e-07 6.853560862272406 1.30480009363434 up QHGCTANDANTK(ub)YNSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QHGCTANDANTKYNSR 16 1 Q8N6H7;G5E9L0;Q8N6H7-2;E9PIY6;E9PK28;E9PJT7;H0YDX1;H0YF45;E9PN48 Q8N6H7;E9PN48 ARFGAP2 ADP-ribosylation factor GTPase-activating protein 2 1 9828800.0 1881000.0 2029400.0 5918400.0 True False 2434991.580053238 1916462.106014025 4841311.927912178 1.0 0.787050814349068 1.988225325939866 21.21548535295153 -6.861088477502414 1.180120160919734 0.8841002695223219 2.047641589247599 0.9549563701387923 0.11106634419413361 0.14569037680846222 0.3849169797681472 0.07336784622097679 0.17148960078254002 1.3769289227489842e-07 6.861088477502414 1.1635413197252773 QHGEQLGGGGSGGGGYNNSK(ub)HR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QHGEQLGGGGSGGGGYNNSKHR 22 1 H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;E9PMX1 H0YEH2 PUM1 Pumilio homolog 1 1 7346970.0 762770.0 1800400.0 4783800.0 True False 1157177.855956553 1479104.5534105934 3838279.8331859736 1.0 1.278199842657659 3.316931631061288 20.14217919019712 -6.931766299182096 0.7321538577213849 0.9709385200485476 3.7549345568224544 0.9968740419183648 0.05774987488901501 0.0917311452332432 0.07326427869286085 0.05317670283353772 0.1827115562594647 1.1701288867326794e-07 6.931766299182096 2.7839960367739067 up QHGEQLGGGGSGGGGYNNSK(ub)HR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QHGEQLGGGGSGGGGYNNSKHR 22 1 H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;E9PMX1 H0YEH2 PUM1 Pumilio homolog 1 1 7522170.0 762770.0 1443400.0 5316000.0 True False 987420.8014445554 1363073.521149426 4348542.546766212 1.0 1.3804383289832525 4.403940589872602 19.91330551228957 -6.9302187872332786 0.7449951162671473 0.9543932428502234 5.02812039649588 0.996581061218631 0.08904673407532271 0.09252435380241718 0.07712503624663532 0.08123170803524862 0.27324633898866335 1.1743058185520763e-07 6.9302187872332786 4.073727153645657 up QHHPPYHQQHHQGPPPGGPGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QHHPPYHQQHHQGPPPGGPGGR 22 0 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 6524400.0 1271000.0 1442300.0 3811100.0 False True 1230652.8007102269 2018217.9114951384 2812858.5794507274 1.0 1.6399571920938194 2.2856638182819617 20.23099236660895 -6.97101418103556 0.23269365505810097 0.7460848103730504 3.1980459555551093 0.9999892478116219 0.001721072768286519 0.07597498620429682 0.00784281026392143 0.016266776133896953 0.0638008357310343 1.0690199718996838e-07 6.97101418103556 2.451961145182059 QHHPPYHQQHHQGPPPGGPGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QHHPPYHQQHHQGPPPGGPGGR 22 0 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 3877040.0 1271000.0 1148740.0 1457300.0 False True 1056892.8148470006 1142551.5096129638 1762014.6922061045 1.0 1.0810476649690948 1.6671649834814892 20.011397642043228 -6.932024225367716 0.7299821094575129 0.9917225508235377 1.79394020166945 0.9969214309799708 0.01649280222855138 0.09160006595588192 0.0726293925555977 0.015210954695411966 0.052455550677590536 1.169434157028178e-07 6.932024225367716 0.8022176508459122 QHIVNDMNPGNLHLFINAYNSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QHIVNDMNPGNLHLFINAYNSR 22 0 Q92597;Q92597-3;Q92597-2 Q92597 NDRG1 Protein NDRG1 0 12573900.0 5757800.0 2180500.0 4635600.0 False True 5575021.790660374 3051185.0211572824 3421397.294980918 1.0 0.5472956224617488 0.613701151933192 22.410546013319667 -10.557150329882418 6.346939120057704 1.0006486250829871 0.580498387197519 0.98155339573763 0.02710994388406435 0.0002491841247954938 1.7386450195647345e-05 0.026287306056115064 0.008749696764966565 2.7723602933848536e-11 10.557150329882418 -0.4201502378854681 QHIVNDMNPGNLHLFINAYNSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QHIVNDMNPGNLHLFINAYNSR 22 0 Q92597;Q92597-3;Q92597-2 Q92597 NDRG1 Protein NDRG1 0 35753100.0 6349100.0 11530000.0 17874000.0 False True 9632048.881384622 9472381.415698826 14341196.06554749 1.0 0.9834233123552376 1.4889039956248562 23.19941128292846 -6.899318969565049 0.9655752314906194 0.9785887705446865 1.5412325498896877 0.9862237482899687 0.02752102826504214 0.1119087005101245 0.18026711133255416 0.021404080093577225 0.05550118099409623 1.2609011198433052e-07 6.899318969565049 0.5626437793450012 QHIVNDMNPGNLHLFINAYNSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QHIVNDMNPGNLHLFINAYNSR 22 0 Q92597;Q92597-3;Q92597-2 Q92597 NDRG1 Protein NDRG1 0 8523400.0 5757800.0 1223000.0 1542600.0 False True 4787865.813789183 1216411.4562535058 1865150.527823469 1.0 0.25406130905970836 0.3895578114264992 22.190951288753944 -9.833625559522206 6.362638896885738 1.000000025711757 0.3218095602882525 0.9709327945008268 0.05531621545567158 2.0127797891343783e-08 3.763069398383239e-09 0.053559697702793015 0.017853231769498618 1.4668119534190048e-10 9.833625559522206 -0.6781904654235045 QHLEIELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QHLEIELK 8 0 P15924;P15924-3 P15924 DSP Desmoplakin 0 5974300.0 2636100.0 1619300.0 1718900.0 False True 3455952.628028713 1377706.751981964 1541044.716853081 1.0 0.3986474643223951 0.4459102547745563 21.720652011427276 -10.006707389160871 7.487935676245551 1.0000000210864217 0.42227886173544404 0.9950055347285373 0.019294953404646906 6.802008629236673e-09 8.736857934226904e-10 0.018682258996477262 0.0062274194335038046 9.846743178165314e-11 10.006707389160871 -0.5777211593509777 QHLEIELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QHLEIELK 8 0 P15924;P15924-3 P15924 DSP Desmoplakin 0 4891000.0 2636100.0 1133500.0 1121400.0 False True 3610737.4079238973 1083418.2220167527 856548.4159579589 1.0 0.30005455939253606 0.23722257234165842 21.783862072950168 -13.999999999999998 0.34118250973482334 9.15424548458097 0.2275008137409432 0.9997375560661667 0.005600703044441388 19.812879416094123 0.18744121844727893 116.5888169107122 0.019331262837184154 1.0000000000000041e-14 13.999999999999998 -8.926744670840026 QHLENDPGSNEDTDIPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QHLENDPGSNEDTDIPK 17 0 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 0 6948570.0 1520800.0 777070.0 4650700.0 False True 1472523.036443833 1087358.1033665163 3432542.1519906307 1.0 0.7384319813376256 2.331061767481937 20.48985877336518 -6.86475334796868 1.1615735954958208 0.8558722881852491 2.4154550778858686 0.9591557118650433 0.14093325361366363 0.14198011968396862 0.3613679393727436 0.0944357512856789 0.2217459956174907 1.365358354354847e-07 6.86475334796868 1.5595827897006194 up QHLSNMEVQVASQSSQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QHLSNMEVQVASQSSQR 17 0 P12270 P12270 TPR Nucleoprotein TPR 0 5641700.0 1595100.0 2406800.0 1639800.0 False True 2091191.5469703726 2047714.8216329184 1470129.226072302 1.0 0.9792095920622664 0.7030103140012025 20.995893783909594 -6.9219794064309 0.8099164679548781 1.0056703973265588 0.6563785682390334 0.9947131924622544 0.00984268544817341 0.0970211280282266 0.09968341052999526 0.008570594283055321 0.026179363834764137 1.1967972802280336e-07 6.9219794064309 -0.34929182908752543 QHLSNMEVQVASQSSQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QHLSNMEVQVASQSSQR 17 0 P12270 P12270 TPR Nucleoprotein TPR 0 5284900.0 1595100.0 1361400.0 2328400.0 False True 2184851.575956681 1301248.8464522348 1778479.8749032558 1.0 0.5955776862702707 0.814004893730373 21.059103845432485 -10.067463977494645 5.08955329870523 1.000005295870753 0.7047912899992813 0.7089194009727001 0.08917253404000133 5.358672533272454e-06 9.8186548909551e-07 0.08634248353739826 0.028780311605817382 8.561227197747229e-11 10.067463977494645 -0.29521400587147173 QHLSSVVFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QHLSSVVFIK 10 0 O43324 O43324 EEF1E1 Eukaryotic translation elongation factor 1 epsilon-1 0 29054400.0 6297800.0 8749600.0 14007000.0 False True 8256476.787981964 7444193.785673673 12557690.00463152 1.0 0.9016186900094432 1.5209501978992244 22.977094854014094 -6.866253672693298 1.1537999701310855 0.9454448349267374 1.5547191379584373 0.9607951827775925 0.05380734163305823 0.140493699071502 0.3519290774479176 0.03627016160980133 0.08535105067828357 1.360649690795301e-07 6.866253672693298 0.6092743030316999 QHLSSVVFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QHLSSVVFIK 10 0 O43324 O43324 EEF1E1 Eukaryotic translation elongation factor 1 epsilon-1 0 19869100.0 7212400.0 3038500.0 9618200.0 False True 6983446.309868157 4251788.895568177 7098904.8801849885 1.0 0.6088382020722443 1.016533179349239 22.735507747181323 -10.977411587823134 12.237777074560062 1.0991149124607822 0.8126856907122425 0.21963743054177476 0.16644077750403655 0.07872581251934001 0.00014531153301612892 0.02818769819540701 0.053718529950245654 1.0533881104315795e-11 10.977411587823134 -0.2864292217485397 QHLSSVVFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QHLSSVVFIK 10 0 O43324 O43324 EEF1E1 Eukaryotic translation elongation factor 1 epsilon-1 0 20646700.0 6297800.0 6236000.0 8112900.0 False True 8626266.851645667 5960472.900305664 6196800.110420309 1.0 0.6909678314865209 0.7183640637361133 23.040304915536986 -10.05266723187208 5.089274038015741 1.0000044573561495 0.7046659476100773 0.9935875770221041 0.01118446498535884 15497737.633548398 5.184829189197078 809.492094770306 0.0038287398531602333 8.857940691416381e-11 10.05266723187208 -0.29533850974607223 QHPFYFK(ub)AAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QHPFYFKAAR 10 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 3838600.0 1154100.0 1159600.0 1524900.0 True False 1513036.276320297 986592.2000853968 1367117.9758736782 1.0 0.6520611670229006 0.9035592849092211 20.529015147123367 -9.856115761695472 6.1998779584079085 1.0000000179796569 0.7778102259659819 0.5099673710499093 0.10267367668225126 2.5626159673379333e-08 4.5397862104849685e-09 0.09941336885917768 0.03313778665697891 1.392785504878473e-10 9.856115761695472 -0.22218979201367495 QHPFYFK(ub)AAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QHPFYFKAAR 10 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 3222930.0 1154100.0 837430.0 1231400.0 True False 1580801.9583797907 800429.5735893161 940568.6814790724 1.0 0.5063439916342838 0.5949946332575956 20.59222520864626 -10.434969399048255 6.685934581428996 1.0000749557172761 0.5506693124459975 0.9716341595861759 0.03619147289124163 4.044363237677018e-05 3.4179233446668977e-06 0.03504804170575674 0.011680747648541332 3.6730818059648795e-11 10.434969399048255 -0.44940564327127863 QHPFYFK(ub)AAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QHPFYFKAAR 10 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 3858280.0 805380.0 1545100.0 1507800.0 True False 669709.1543835379 1536776.2396216623 1823074.008720486 1.0 2.2946920010915077 2.722187679215183 19.3531751630983 -9.97849345178448 0.2737864699484837 6.557467050812974e-15 2.9150161138151263 0.9989815018198014 0.023367028280769746 1.4094035372420786 0.12267766878202832 1.268663274891136 0.17039082496602945 1.0507672980299086e-10 9.97849345178448 2.9150161138151196 QHPFYFK(ub)AAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QHPFYFKAAR 10 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 10977600.0 3166400.0 3006800.0 4804400.0 True False 4098967.219075268 2839468.9368103733 3930048.4973069187 1.0 0.6927278958456664 0.9587899310386635 21.966829021588484 -10.16306184626209 7.102608251151526 1.0000001980190165 0.8257589140194744 0.36380268017869233 0.10861937102487726 3.4063179109057057e-07 4.0157582200807716e-08 0.1051703744339581 0.03505675125457284 6.869706041191846e-11 10.16306184626209 -0.17424128399954208 QHQLYVGVLGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QHQLYVGVLGSK 12 0 O94760 O94760 DDAH1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 0 19072900.0 6227100.0 3198000.0 9647800.0 False True 8163788.4033221835 2720870.8657063656 8649538.20423245 1.0 0.3332853243230962 1.059500537852328 22.960807359064496 -12.085056628827871 15.135922200249109 0.9286580985782154 0.7267536379792222 0.0 0.33674985156351495 0.0 0.0 0.0 0.09809742435481215 8.221354425017765e-13 12.085056628827871 -0.20190446059899314 QHQLYVGVLGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QHQLYVGVLGSK 12 0 O94760 O94760 DDAH1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 0 13303800.0 5484800.0 1296700.0 6522300.0 False True 5310688.026227733 1814479.072201169 4813913.965194169 1.0 0.34166553622431906 0.9064576833396801 22.34046735082913 -10.39287179339301 8.461008772399124 1.0000027428344485 0.6240616097820381 0.37136090320915915 0.2305754285272608 1.192991297639794e-05 8.559756022893752e-07 0.22325532482550656 0.07441789956089333 4.046953428103178e-11 10.39287179339301 -0.3759411330524104 QHQLYVGVLGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QHQLYVGVLGSK 12 0 O94760 O94760 DDAH1 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 0 23566900.0 6227100.0 6290200.0 11049600.0 False True 8529427.151050001 6012278.165090231 8439912.053655306 1.0 0.7048865133164423 0.9895051454441842 23.024017420587388 -10.685862494116142 9.149789888147474 1.0002041000133195 0.8471958294618775 0.2776188274980719 0.11619507000031377 0.00048441281345743746 1.663111842798761e-05 0.11265359188499183 0.03750179758521837 2.061282451146645e-11 10.685862494116142 -0.15300827055144195 QHQQQK(ub)ALQSGPPQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QHQQQKALQSGPPQSR 16 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 10185200.0 2848500.0 3507800.0 3828900.0 True False 2758075.926690069 4908482.832935337 2825996.2254621736 1.0 1.7796764713529636 1.024625971357364 21.395230742474645 -10.436607939661613 4.935653930992212 0.9993336826057948 1.4021512213552083 0.27443607665049763 0.3082480758372434 0.0022637150054121108 0.000258397385078936 0.2989371109616287 0.09948663868482159 3.659249821664453e-11 10.436607939661613 0.4028175387494135 QHQQQK(ub)ALQSGPPQSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QHQQQKALQSGPPQSR 16 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 9931300.0 4375300.0 2037500.0 3518500.0 True False 6637649.977275861 1673892.2059398377 2823066.9327866635 1.0 0.2521814515183 0.42531120840229514 22.662241123211235 -10.585759172396939 9.618159799092917 1.000068569916428 0.33874632998630233 0.9511015167732426 0.07067992727631522 0.00010393647165378752 4.476355445246878e-06 0.06844248404606088 0.02281184843769335 2.5956183010780377e-11 10.585759172396939 -0.6613222399301257 QHQQQK(ub)ALQSGPPQSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QHQQQKALQSGPPQSR 16 1 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 8999800.0 4375300.0 2514900.0 2109600.0 True False 5663912.100056852 2374943.6042252276 1725674.4463239277 1.0 0.41931152219000517 0.3046788890503096 22.433367445303684 -13.999999999999998 0.2281052624590968 4.633863175267335 0.24792913231098984 0.9995072655680091 0.006756455236639338 13.232937894119676 0.1512376280599122 21.75594592622042 0.06021382766094577 1.0000000000000041e-14 13.999999999999998 -4.385934042956345 QHWTMTK(ub)IQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QHWTMTKIQK 10 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 10158800.0 3685300.0 6473500.0 0.0 True False 4831463.988495967 5507679.033505362 0.0 1.0 1.1399606923738865 0.0 22.204028977622748 -6.9406744996790275 1.2205942343895382 1.0765443015178686 5.399400701760156e-22 0.9685345415495141 0.09004414025841943 0.11175086811540573 0.33170618174171945 0.06113244163176638 0.11711036069243004 1.1463718162648467e-07 6.9406744996790275 -1.0765443015178686 down QHWTMTK(ub)IQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QHWTMTKIQK 10 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 13512500.0 6369900.0 7142600.0 0.0 True False 6167691.011206969 9994677.428166945 0.0 1.0 1.620489322504349 0.0 22.55629906029608 -6.8181724011797264 1.481714518667279 1.3401063943409914 1.0954734493481333e-18 0.8399953005767453 0.2670367582044146 0.2078215567242535 0.9134571527191239 0.14381930682701516 0.3165382512903431 1.5199440402241462e-07 6.8181724011797264 -1.3401063943409914 QHWTMTK(ub)IQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QHWTMTKIQK 10 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 33849800.0 9959100.0 7485700.0 16405000.0 True False 15108682.807736136 6149818.348958955 13162544.559433071 1.0 0.40703868280364247 0.8711907402472849 23.848874554391312 -9.957637456762502 6.818357778116694 1.0000000281947612 0.6391147115254816 0.44630237265761386 0.1894892839666584 8.126917899699545e-08 1.2430035779715155e-08 0.18347222394161486 0.06115740342396873 1.1024592437771178e-10 9.957637456762502 -0.3608853166692796 QHWTMTK(ub)IQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QHWTMTKIQK 10 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 16055800.0 3685300.0 4994700.0 7375800.0 True False 5047855.001487781 4774017.638735841 5633787.9493692815 1.0 0.9457517375853247 1.116075629689998 22.26723903914564 -6.821027354705968 1.367288110112445 0.9707887673943796 1.1198801356430188 0.8867360926755125 0.023910016643938235 0.1921665540483559 0.7056060282180882 0.013740254557978867 0.03166284110143776 1.5099850424382673e-07 6.821027354705968 0.14909136824863922 QHWTMTK(ub)IQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QHWTMTKIQK 10 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 20287400.0 6369900.0 10533000.0 3384500.0 True False 5296854.084416912 10476256.638363194 4092183.3018400925 1.0 1.9778261721771482 0.7725686297228949 22.336704335730357 -6.690978444463268 1.8638191666762114 1.612500943697557 0.7767818856567078 0.37466751164794054 0.41347307303992326 0.4145362588293934 2.7929369613238713 0.17745656735410106 0.461390348039109 2.0371431856563572e-07 6.690978444463268 -0.8357190580408492 QHWTMTK(ub)IQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QHWTMTKIQK 10 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 35321100.0 9959100.0 10509000.0 14853000.0 True False 12892251.273210088 9924164.91184657 12149906.404649844 1.0 0.7697774966943781 0.9424192987843151 23.62000087648376 -10.483175944594098 5.2203167952664105 1.0002884565021712 0.8560983977393448 0.48088524090390705 0.07048072056582373 0.00023709026511610615 2.3472525399323625e-05 0.06837864446219889 0.02274755474834356 3.287184310531948e-11 10.483175944594098 -0.14419005876282642 QHYIDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QHYIDLK 7 0 Q32Q12;P22392-2;J3KPD9;P22392;O60361;F6XY72 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 9211500.0 6867000.0 2344500.0 0.0 False True 6649010.843805767 3280671.076405986 0.0 1.0 0.4934073884782827 0.0 22.664708299880836 -7.949266152774505 0.5889094757149662 1.0116211910270263 1.278675419667035e-18 0.9891623666106714 0.04250149258699923 0.11203773638376859 0.1624966090060112 0.04522148185021602 0.07678846416588038 1.1239159828590512e-08 7.949266152774505 -1.0116211910270263 QHYIDLK(ub)DRPFFPGLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QHYIDLKDRPFFPGLVK 17 2 Q32Q12;P22392-2;J3KPD9;P22392;O60361;F6XY72 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 1 56086200.0 25339000.0 23254000.0 7493200.0 True False 24534627.31486735 32539443.468008004 5530506.128818502 1.0 1.3262660585958825 0.22541634962872079 24.548316021002787 -6.8273037944800015 1.339903731638405 1.1746849660492458 0.19738881092782914 0.9003800837242785 0.14571693668959676 0.18415844500289602 0.6475613920193558 0.08541051406902207 0.1965898505317278 1.4883196151106591e-07 6.8273037944800015 -0.9772961551214167 down QHYIDLK(ub)DRPFFPGLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QHYIDLKDRPFFPGLVK 17 2 Q32Q12;P22392-2;J3KPD9;P22392;O60361;F6XY72 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 1 121973000.0 78164000.0 23197000.0 20612000.0 True False 118580502.55383392 19057314.11101177 16538029.165439453 1.0 0.160712036975556 0.1394666813621524 26.82129157521137 QHYIDLK(ub)DRPFFPGLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QHYIDLKDRPFFPGLVK 17 2 Q32Q12;P22392-2;J3KPD9;P22392;O60361;F6XY72 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 1 37957700.0 11529000.0 21064000.0 5364700.0 True False 15791582.859510109 20133322.830666866 4097668.3494646563 1.0 1.274940138033221 0.25948433326282627 23.91265245029981 -6.834589419275482 1.3072063932382876 1.1465113988610738 0.2294916853791103 0.9147592090874758 0.12520318873451053 0.17521342249446586 0.583898384466118 0.07516211055006694 0.1729949491224531 1.463560166087529e-07 6.834589419275482 -0.9170197134819635 down QHYIDLK(ub)DRPFFPGLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QHYIDLKDRPFFPGLVK 17 2 Q32Q12;P22392-2;J3KPD9;P22392;O60361;F6XY72 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 1 115909000.0 78164000.0 24823000.0 12922000.0 True False 101184838.84278633 23441578.228829328 10570328.590916678 1.0 0.23167085599900153 0.10446553764186045 26.592417897303818 -13.999999999999998 0.25306253504101295 6.426942787299797 0.05478789886885467 0.9995485293836981 0.008405638521463133 14.121489426722926 0.1591805258515062 39.02844772093136 0.057721660307703364 1.0000000000000041e-14 13.999999999999998 -6.372154888430942 QIAEEDFYEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QIAEEDFYEK 10 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 10297430.0 696330.0 3606000.0 5995100.0 False True 912895.3732693127 3067998.8560779057 5374784.561059918 1.0 3.3607343688144833 5.887623837780485 19.800089997170918 -6.97026012435709 0.2518966342401325 0.21656365431734814 9.105982847948049 0.9999843408501065 0.007897502232875492 0.07621840018172354 0.008727668242776546 0.05564242639873753 0.24143504158898837 1.0708777018432981e-07 6.97026012435709 8.889419193630701 QIAEEDFYEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QIAEEDFYEK 10 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 10003030.0 696330.0 3993000.0 5313700.0 False True 953782.0186106933 3816576.0569147733 4058713.499086687 1.0 4.00151814821809 4.255388988145035 19.86330005869381 -10.087859538059295 0.5577211057465312 1.5860510559952534e-21 4.234748374360713 0.9994983731234421 0.03311186714660689 1.3708863450853896 0.2620470775518534 2.3267545388607416 0.046670260461288235 8.168465176916917e-11 10.087859538059295 4.234748374360713 QIAEEDFYEK(ub)LAASIAPEIYGHEDVKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIAEEDFYEKLAASIAPEIYGHEDVKK 27 2 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 126735500.0 9550500.0 18238000.0 98947000.0 True False 14488806.73507487 14983286.405855596 79390082.07998934 1.0 1.03412839164896 5.479407899602927 23.788435446940877 -6.90858262440162 0.9053313829547696 0.8561197813859426 6.036806530381075 0.9903756449183956 0.2063726332626783 0.10536280437600504 0.14390600855575988 0.1677847889365003 0.4587381906906095 1.2342904694210927e-07 6.90858262440162 5.180686748995133 up QIAEEDFYEK(ub)LAASIAPEIYGHEDVKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QIAEEDFYEKLAASIAPEIYGHEDVKK 27 2 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 8828600.0 2089700.0 1881600.0 4857300.0 True False 1737678.1394065893 1871463.4473316418 5872938.972382292 1.0 1.0769908447894383 3.379762246642453 20.728729453729933 -6.914006356014987 0.8680025754252538 0.9374145678331829 3.7043462484455776 0.9923477623641096 0.0965861643363693 0.10182806923687866 0.12483613471287837 0.08067747186096356 0.2294030075160136 1.2189717588191633e-07 6.914006356014987 2.7669316806123945 up QIAEEDFYEK(ub)LAASIAPEIYGHEDVKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIAEEDFYEKLAASIAPEIYGHEDVKK 27 2 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 243210500.0 9550500.0 10020000.0 223640000.0 True False 12363310.518499974 9462378.191712111 182939814.7401799 1.0 0.7653595837096365 14.796992639344932 23.559561769033326 -6.903100265003307 0.9414829251027439 0.46519780907094693 16.366083505442237 0.9880459941998814 0.7172301630037407 0.10915835407018859 0.16483841518988268 0.5678687186977721 1.5018196750950146 1.249970417855359e-07 6.903100265003307 15.90088569637129 up QIAK(ub)CQQLQQEYSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIAKCQQLQQEYSR 14 1 Q96JB5;Q96JB5-4;Q96JB5-2;J3QQY1;J3QS62;J3QL86 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 25230600.0 2013900.0 4932700.0 18284000.0 True False 3055233.5358114485 4052421.145638995 14670159.385838099 1.0 1.326386706004358 4.801649109269092 21.54285123024541 -6.925192124724074 0.7852507038714936 0.9366907120580453 5.434961240893927 0.9955059832792359 0.11532800301821082 0.09521240793702748 0.09048080365483947 0.10220525265085968 0.3231620518927434 1.1879765699110921e-07 6.925192124724074 4.498270528835882 up QIAK(ub)CQQLQQEYSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIAKCQQLQQEYSR 14 1 Q96JB5;Q96JB5-4;Q96JB5-2;J3QQY1;J3QS62;J3QL86 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 1 24373100.0 2013900.0 4333200.0 18026000.0 True False 2607033.249903886 4092053.61081107 14745452.962379191 1.0 1.5696207982625203 5.656027963173394 21.31397755233786 -6.93218224617335 0.7286564328944807 0.9426126246575537 6.543553565098376 0.9969500232788748 0.1145229484283008 0.09152048191595438 0.07224442442514044 0.10572443917901883 0.3654137711319351 1.1690087283847068e-07 6.93218224617335 5.600940940440823 up QIATLHAQVADMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 QIATLHAQVADMK 13 0 P35579 P35579 MYH9 Myosin-9 0 64353700.0 25801100.0 34250000.0 4302600.0 False True 33825491.95820778 29140033.505454317 3857408.2254535267 1.0 0.8614814395443986 0.11403849588409383 25.01160758113339 -7.0392255194312225 0.748124360526054 1.0030254212840677 3.9905002207148015e-25 0.997257459909 0.020378352633155135 0.07710551740488283 0.07000501966037903 0.019191001908004705 0.054564717508227986 9.13638686090165e-08 7.0392255194312225 -1.0030254212840677 down QIATLHAQVADMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QIATLHAQVADMK 13 0 P35579 P35579 MYH9 Myosin-9 0 10933300.0 1794100.0 2058500.0 7080700.0 False True 1737147.2775406877 2880469.784935686 5226052.253553246 1.0 1.6581609528315995 3.0084105827525844 20.72828864206581 -6.9595440008354075 0.44181303854637527 0.9526233755536532 3.7667512595579624 0.9997529125432639 0.0131410948406457 0.07986440844848741 0.02173619749600903 0.01784313133408992 0.11183897599348169 1.0976300775158328e-07 6.9595440008354075 2.8141278840043094 QIATLHAQVADMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIATLHAQVADMK 13 0 P35579 P35579 MYH9 Myosin-9 0 77209000.0 16186000.0 61023000.0 0.0 False True 24555345.355104093 50132968.87512481 0.0 1.0 2.0416315938600365 0.0 24.54953377746324 -6.773461111999226 1.5969787015512782 1.5986825598088517 3.450641934506817e-12 0.7226767691121897 0.43896002618449026 0.2657178237662078 1.343655911030056 0.21787829089203814 0.5095762189010696 1.6847632786618974e-07 6.773461111999226 -1.598682559805401 QIATLHAQVADMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QIATLHAQVADMK 13 0 P35579 P35579 MYH9 Myosin-9 0 15908500.0 7955100.0 3349100.0 4604300.0 False True 10896315.448494129 3201125.6880073315 3516859.168535073 1.0 0.29378056308471934 0.3227567323246963 23.377337039321603 -10.028754196286902 5.16746541377391 1.000005576681576 0.30826864772093826 0.9986856918074625 0.01182947158111374 32704996.834699053 5.238681766733405 2577.283333448495 0.004049542763834626 9.359352486116236e-11 10.028754196286902 -0.6917369289606379 QIATLHAQVADMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 QIATLHAQVADMK 13 0 P35579 P35579 MYH9 Myosin-9 0 80799500.0 22649000.0 35708900.0 22441600.0 False True 29319576.97853578 33721668.3243541 18357459.07026121 1.0 1.1501417073323055 0.6261160958666049 24.805360952697885 -6.830104974346161 1.327403578732245 1.0802203687957315 0.6119808946052966 0.9060920274317444 0.06752089160734409 0.18068112118426 0.622587510332144 0.0399378957011383 0.09190989788646949 1.4787509125870541e-07 6.830104974346161 -0.4682394741904349 QIATLHAQVADMKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIATLHAQVADMKK 14 1 P35579 P35579 MYH9 Myosin-9 0 16661800.0 3361300.0 5502800.0 7797700.0 False True 4351269.1111286245 5196564.342650044 6378598.611158563 1.0 1.1942640663983588 1.4659168275400216 22.053004814721266 -6.966396915995253 0.33320812723721105 0.9681179375792774 1.7009987147998769 0.9999391112627355 0.0014910281456722745 0.07749007572186208 0.01320567982511008 0.003919806402650088 0.023633890396168672 1.080446044789461e-07 6.966396915995253 0.7328807772205994 QICLVMLETLSQSPQGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 QICLVMLETLSQSPQGR 17 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 9574890.0 4015490.0 3191400.0 2368000.0 False True 5264346.276060474 2715255.559979765 2122982.075459944 1.0 0.5157820966921086 0.4032755377650914 22.327822958534977 -13.999999999999977 0.20505052995343354 3.7450065841476214 0.333740110356967 0.9994878378928719 0.005858880582852279 12.635326562223714 0.14355811137748795 13.941183945378352 0.0690315303042255 1.0000000000000532e-14 13.999999999999977 -3.4112664737906546 QICLVMLETLSQSPQGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QICLVMLETLSQSPQGR 17 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 63644000.0 0.0 42585000.0 21059000.0 False True 0.0 34985374.03187636 16896679.419512425 0.0 QICLVMLETLSQSPQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QICLVMLETLSQSPQGR 17 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 6238990.0 676490.0 2445900.0 3116600.0 False True 926606.6344548534 2337832.05049032 2380523.2683918094 1.0 2.523003789915369 2.5690764342436774 19.821597486465723 -10.6976578482469 0.6408239289630276 1.0939067983939327e-11 2.5624596459829814 0.9999123878915374 0.006824031042767873 2.252468176490852 0.3185980762466139 3.549346015348205 0.007621308373079208 2.0060518398636226e-11 10.6976578482469 2.562459645972042 QICVVMLESPPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QICVVMLESPPK 12 0 Q15366-3;E9PFP8;P57721-5;P57721-4;P57721;Q15366-4;Q15366-7;F8VRH0;Q15366-6 Q15366-3;Q15366-4;Q15366-6 PCBP2;PCBP3 Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 0 34328000.0 10491000.0 13645000.0 10192000.0 False True 13753802.59498853 11609219.187793417 9137429.608567452 1.0 0.8440734195227918 0.6643566057794704 23.713327208411833 -6.969265974806056 0.2751581852596167 1.041973033254885 0.4610166032417033 0.99997607417913 0.0006707847103193509 0.07654162734364069 0.009879787606728798 0.00341495706468486 0.016599009906965133 1.0733318707792791e-07 6.969265974806056 -0.5809564300131818 QICVVMLESPPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QICVVMLESPPK 12 0 Q15366-3;E9PFP8;P57721-5;P57721-4;P57721;Q15366-4;Q15366-7;F8VRH0;Q15366-6 Q15366-3;Q15366-4;Q15366-6 PCBP2;PCBP3 Poly(rC)-binding protein 2;Poly(rC)-binding protein 3 0 38848000.0 10491000.0 13634000.0 14723000.0 False True 14369806.208614862 13031604.798391173 11245730.629703088 1.0 0.9068740809168726 0.7825944530108656 23.776537269934725 -6.967127660433933 0.3194531713179676 1.0171296622279378 0.6683336338019176 0.999950507613641 0.0006265085564473779 0.07724636486145332 0.012353184662065676 0.0018880257804068151 0.010937204983865845 1.0786296135158585e-07 6.967127660433933 -0.3487960284260202 QIEIQFAQGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QIEIQFAQGDR 11 0 Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3;O75494-2;O75494;Q8WXF0 Q5JRI1 SRSF10;SRSF12 Serine/arginine-rich splicing factor 10;Serine/arginine-rich splicing factor 12 0 32029000.0 11223000.0 10991000.0 9815000.0 False True 14713461.683686605 9351185.64258244 8799437.952128105 1.0 0.6355530631483187 0.5980535472413259 23.810633378264942 -13.999999999999998 0.3213404427985201 4.766733113101239 0.5907196031211499 0.9996965958634673 0.0031577633722367406 18.117833499662037 0.18083984256391344 45.9134221785548 0.01241977116885941 1.0000000000000041e-14 13.999999999999998 -4.1760135099800895 QIEIQFAQGDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QIEIQFAQGDR 11 0 Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3;O75494-2;O75494;Q8WXF0 Q5JRI1 SRSF10;SRSF12 Serine/arginine-rich splicing factor 10;Serine/arginine-rich splicing factor 12 0 19022300.0 6127000.0 3511200.0 9384100.0 False True 5932501.738750233 4913240.470666111 6926122.693034438 1.0 0.8281903127939337 1.1674876802469385 22.50020918758132 -6.769014968123656 1.5780221275500241 0.9013338236013188 1.1693355817606763 0.7268882907884795 0.07239136544434127 0.2680056249118326 1.3169071823408873 0.03616155819366657 0.08616461063164542 1.7020998438688138e-07 6.769014968123656 0.26800175815935756 QIEIQFAQGDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIEIQFAQGDR 11 0 Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3;O75494-2;O75494;Q8WXF0 Q5JRI1 SRSF10;SRSF12 Serine/arginine-rich splicing factor 10;Serine/arginine-rich splicing factor 12 0 50205600.0 7917600.0 27893000.0 14395000.0 False True 12011578.054094426 22915276.22099629 11549821.940447368 1.0 1.9077656672417895 0.9615574147237334 23.51792236573461 -6.655599976643972 1.988685652137052 1.586422625948422 0.9655367569258932 0.2170408393144032 0.3869161250948588 0.4949329282243814 3.7580567359314947 0.15745161538945515 0.4286898146040812 2.210039436203425e-07 6.655599976643972 -0.6208858690225287 QIEIQFAQGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QIEIQFAQGDR 11 0 Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3;O75494-2;O75494;Q8WXF0 Q5JRI1 SRSF10;SRSF12 Serine/arginine-rich splicing factor 10;Serine/arginine-rich splicing factor 12 0 18391500.0 11223000.0 7168500.0 0.0 False True 15372446.390171051 6851771.966940532 0.0 1.0 0.44571773373179363 0.0 23.873843439787834 -8.108481525842961 0.5612927117744796 1.0206386665133518 4.374851597347037e-17 0.9904665159465345 0.03993940943353134 0.11676465963924436 0.16933488363767504 0.049603752079285544 0.07461336560913714 7.789659497506604e-09 8.108481525842961 -1.0206386665133518 QIEIQFAQGDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QIEIQFAQGDR 11 0 Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3;O75494-2;O75494;Q8WXF0 Q5JRI1 SRSF10;SRSF12 Serine/arginine-rich splicing factor 10;Serine/arginine-rich splicing factor 12 0 13232200.0 6127000.0 4522900.0 2582300.0 False True 5094871.972122394 4498534.239974643 3122246.990793815 1.0 0.8829533430063148 0.6128214816540652 22.280614463015596 -6.957151688858736 0.4738780676749317 1.006872561329926 0.477755664501807 0.999649518389141 0.0030352752104980526 0.08073480810223302 0.0250136682642828 0.0037627736545240665 0.022289879107763057 1.1036930585182665e-07 6.957151688858736 -0.529116896828119 QIEIQFAQGDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIEIQFAQGDR 11 0 Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3;O75494-2;O75494;Q8WXF0 Q5JRI1 SRSF10;SRSF12 Serine/arginine-rich splicing factor 10;Serine/arginine-rich splicing factor 12 0 21455600.0 7917600.0 0.0 13538000.0 False True 10249489.279228881 0.0 11074222.91161042 1.0 0.0 1.0804658271171526 23.28904868782706 -10.601115279089663 5.0608117701771675 1.004404102189683 0.5402329135585728 0.1944777647696737 0.44109832682521427 0.022070273787825147 0.0017395405676615776 0.43004517302875683 0.14236387281949905 2.505444119889383e-11 10.601115279089663 -0.4641711886311102 QIESK(ub)TAFQEALDAAGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QIESKTAFQEALDAAGDK 18 1 P10599;P10599-2 P10599 TXN Thioredoxin 1 10414500.0 4087400.0 4068800.0 2258300.0 True False 3398854.2025221274 4046880.5668064323 2730500.088800553 1.0 1.1906602418554568 0.8033589927965664 21.6966170465878 -6.772845531569115 1.563483837908938 1.1089608977762289 0.8009389022426578 0.7413337602122976 0.08041932177667409 0.2618633166379687 1.263661621034272 0.040532909714878516 0.09623857672826869 1.6871529997059204e-07 6.772845531569115 -0.308021995533571 QIEYEYK(ub)LAQALHEMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QIEYEYKLAQALHEMR 16 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 16346800.0 3748400.0 6762100.0 5836300.0 True False 4914188.699557232 5753221.038459353 5232415.661742758 1.0 1.1707366953527278 1.0647567648784424 22.228521826024778 -10.083852676935834 4.140500152170797 0.9999814432044939 1.1177467299938826 0.6220490422046532 0.04326612555338034 15034406.4695535 0.26185642452272767 2716.4087096397266 0.014811145571743662 8.24417729774753e-11 10.083852676935834 0.11776528678938869 QIEYEYK(ub)LAQALHEMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 QIEYEYKLAQALHEMR 16 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 46451300.0 19923900.0 13118700.0 13408700.0 True False 19291426.700291477 18357065.32311672 9896559.217622457 1.0 0.9515659784166901 0.513002971287392 24.201456506267437 -6.927868833329596 0.764093244196672 1.0072233781381432 0.42767025071732273 0.9961022954667118 0.013675693541194358 0.09376004516256203 0.08321605825057715 0.01230467886479597 0.04015762261102113 1.1806771727848441e-07 6.927868833329596 -0.5795531274208205 QIEYEYK(ub)LAQALHEMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIEYEYKLAQALHEMR 16 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 69333000.0 19444000.0 22623000.0 27266000.0 True False 29497969.546808608 18585748.89569424 21876863.14888769 1.0 0.6300687532476295 0.741639627574114 24.814112316124465 -10.517295776257535 9.143762852966917 1.000012117089647 0.6858541904108721 0.9135740510574603 0.045548618709345796 1.1251695127661102e-05 5.939909105602275e-07 0.04410395902197381 0.014700753475337322 3.0388147359905135e-11 10.517295776257535 -0.31415792667877485 QIEYEYK(ub)LAQALHEMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QIEYEYKLAQALHEMR 16 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 16211100.0 3748400.0 6431400.0 6031300.0 True False 5134284.776701159 6147239.482204278 4606831.158522596 1.0 1.1972922713792193 0.8972683360743658 22.29173188754767 -6.729325448673538 1.7257224958273059 1.1188174004595883 0.8974692639518087 0.5561534911568125 0.08294121961175155 0.33748786781784473 1.9687402179384348 0.03809225785592088 0.09459443960568209 1.8649815997049533e-07 6.729325448673538 -0.22134813650777962 QIEYEYK(ub)LAQALHEMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QIEYEYKLAQALHEMR 16 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 30488000.0 15931000.0 10958000.0 3599000.0 True False 13247332.362964232 10898967.079007303 4351534.260104154 1.0 0.8227291941038417 0.32848381401449583 23.65919853526892 -6.953085011264511 0.5238818660503214 1.0081535826631167 0.1208561611320881 0.9994216743624263 0.0068331930942499425 0.0822701050796136 0.031014799134598096 0.007694161044511782 0.04084148350658603 1.1140764366076964e-07 6.953085011264511 -0.8872974215310286 down QIEYEYK(ub)LAQALHEMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIEYEYKLAQALHEMR 16 1 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 1 59223000.0 19444000.0 22515000.0 17264000.0 True False 25170641.29854074 21262020.457724363 14122129.143598923 1.0 0.8447150871343521 0.5610555955289724 24.585238638216914 -6.961778270145827 0.409607652734901 1.0140332041399418 0.3812174141561231 0.999830559223313 0.0023656261359477197 0.07907197616029199 0.018828967530810016 0.0036522460870424293 0.02368644157777208 1.0919977156125911e-07 6.961778270145827 -0.6328157899838187 QIFFGLAPGWVVNMADKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIFFGLAPGWVVNMADKK 18 1 Q9P015;E5RIZ4 Q9P015 MRPL15 39S ribosomal protein L15, mitochondrial 0 25004000.0 4055400.0 9374600.0 11574000.0 False True 6152338.289453183 7701629.385915897 9286393.826935587 1.0 1.2518215064861808 1.509408844252769 22.552703402126262 -6.970842484552093 0.23720429591862757 0.9042408560459642 1.8644141796358906 0.9999882273345493 0.0007135481987712244 0.07603026513474856 0.008045603086114577 0.006281087088652911 0.025238969165602164 1.0694426879705103e-07 6.970842484552093 0.9601733235899265 QIFFGLAPGWVVNMADKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIFFGLAPGWVVNMADKK 18 1 Q9P015;E5RIZ4 Q9P015 MRPL15 39S ribosomal protein L15, mitochondrial 0 16464700.0 4055400.0 8000800.0 4408500.0 False True 5249795.243885116 7555548.446731558 3606198.2350298814 1.0 1.4392082158884483 0.6869216926565522 22.32382972421871 -6.748475343364319 1.6557663612916294 1.2587335453030033 0.6856234407718395 0.6422846782927394 0.18454473717921513 0.30270454922290074 1.632366903313537 0.08806854921450355 0.21412664617569527 1.7845333007611504e-07 6.748475343364319 -0.5731101045311638 QIFILLFQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QIFILLFQR 9 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 7519500.0 1635300.0 2920700.0 2963500.0 False True 2143894.1362677254 2484942.944799434 2656865.4478992997 1.0 1.1590791274449006 1.2392708217041903 21.031802237782024 -13.999999999996964 0.0885288620183925 0.18007953849172811 1.4450798408285717 0.9998492546353601 0.001220843902979751 12.176889055553174 0.08608581955475736 1.888647327774948 0.18516482195241943 1.0000000000069901e-14 13.999999999996964 1.2650003023368435 QIFILLFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QIFILLFQR 9 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 10931900.0 5279000.0 3261200.0 2391700.0 False True 5111421.03457851 4563414.166933332 1765242.0205379834 1.0 0.8927877660756297 0.34535249759239334 22.28529300227462 -6.9393391854582465 0.6656949080533109 1.0062205093246088 0.20055874153433292 0.9980758879411403 0.012575763685211896 0.0880697425459845 0.05599490301072318 0.012180998171840103 0.04725562228488923 1.1499019608344212e-07 6.9393391854582465 -0.8056617677902759 down QIFILLFQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIFILLFQR 9 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 137385000.0 22924000.0 47616000.0 66845000.0 False True 34777383.9688871 39118552.77449398 53633056.45079573 1.0 1.124827353589638 1.5421820255019034 25.05164607825169 -6.9489928011274795 0.5698038558727405 0.9947964591404475 1.6924972008001717 0.9991197800530904 0.006878201131304127 0.08389291957960857 0.03765726397537762 0.007288667381850669 0.03477209067568601 1.1246236155920909e-07 6.9489928011274795 0.6977007416597243 QIFILLFQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QIFILLFQR 9 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 14606400.0 1635300.0 3999600.0 8971500.0 False True 2239914.6023208317 3822884.4470914854 6852616.473842368 1.0 1.706709908998539 3.0593204163865 21.095012299304916 -6.960895730341494 0.42262043955685846 0.9418721456131559 3.8754020155892794 0.9998019910192786 0.012022562325081261 0.0793826885864995 0.01996042973845373 0.017528362696795464 0.1125146096434521 1.0942190455270133e-07 6.960895730341494 2.9335298699761236 QIFILLFQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QIFILLFQR 9 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 14373400.0 5279000.0 2512700.0 6581700.0 False True 4389722.3993527265 2499163.5863681003 7957903.039657538 1.0 0.5693215558998918 1.8128488126791222 22.065698277708897 -6.813166458776571 1.401057213165857 0.766138843591067 1.8362423960328005 0.8679562271363966 0.18735693606649856 0.20251804182530098 0.7828641143876962 0.10512750460957726 0.24286591764495305 1.537565200905449e-07 6.813166458776571 1.0701035524417335 QIFILLFQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIFILLFQR 9 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 83072000.0 22924000.0 31175000.0 28973000.0 False True 29675569.899596184 29440083.844972536 23700211.28808453 1.0 0.9920646492916433 0.7986438463783988 24.82277240034414 -6.9155312806155 0.8572072269848483 1.0049928035930775 0.770447304724629 0.9928470369793561 0.007874472448229022 0.10087306422643103 0.11976432153200788 0.0066287384005782515 0.019082011077124796 1.2146991270621813e-07 6.9155312806155 -0.23454549886844855 QIFNGTFVK(ub)LNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QIFNGTFVKLNK 12 1 P18124;A8MUD9;C9JIJ5;C9JZ88 P18124 RPL7 60S ribosomal protein L7 1 21104600.0 5697100.0 7804900.0 7602600.0 True False 7468953.270794873 6640439.343261915 6815955.88128875 1.0 0.8890722839607772 0.9125717666410532 22.83247464140897 -10.169944983812917 5.218729804390052 1.0000046193661027 0.9008220253008608 0.9595949626103016 0.009593623631199703 5.156427327902045e-07 8.201693730381126e-08 0.009289418680313959 0.0030963287127572336 6.76168626637993e-11 10.169944983812917 -0.09918259406524199 QIFNGTFVK(ub)LNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QIFNGTFVKLNK 12 1 P18124;A8MUD9;C9JIJ5;C9JZ88 P18124 RPL7 60S ribosomal protein L7 1 38057000.0 12023000.0 10392000.0 15642000.0 True False 11641336.446057482 14541579.793564092 11544890.9500586 1.0 1.249133195397752 0.991715255679983 23.472753355913195 -6.6536335151651445 1.9957385059611894 1.1611965483614892 0.9928000096652981 0.2088820604094882 0.10623847855123657 0.49966365800924484 3.818766516120969 0.04311279737214172 0.1176869621092927 2.2200690626308651e-07 6.6536335151651445 -0.1683965386961911 QIFNGTFVK(ub)LNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIFNGTFVKLNK 12 1 P18124;A8MUD9;C9JIJ5;C9JZ88 P18124 RPL7 60S ribosomal protein L7 1 24273000.0 13514000.0 10759000.0 0.0 True False 20501726.005738076 8838972.389549328 0.0 1.0 0.43113308543268275 0.0 24.289242037117734 -8.161193630373115 0.5533418275363168 1.0239891804574337 4.449217772946013e-16 0.9909007451300705 0.03906574402326263 0.12269853907476262 0.17149484031834325 0.05186298071018046 0.07371994726749434 6.899321287338621e-09 8.161193630373115 -1.0239891804574333 QIFNGTFVK(ub)LNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QIFNGTFVKLNK 12 1 P18124;A8MUD9;C9JIJ5;C9JZ88 P18124 RPL7 60S ribosomal protein L7 1 27354400.0 5697100.0 7279300.0 14378000.0 True False 7803471.828338536 6957676.456573922 10982212.524205044 1.0 0.8916129396798635 1.4073495446376596 22.895684702931863 -6.851817459493588 1.2262083327601545 0.9420551452929745 1.42870979909832 0.9429156992860549 0.0530475082831594 0.15547238124481752 0.44891895672997 0.033834406325071696 0.07839505344421334 1.4066386312807334e-07 6.851817459493588 0.48665465380534545 QIFNGTFVK(ub)LNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QIFNGTFVKLNK 12 1 P18124;A8MUD9;C9JIJ5;C9JZ88 P18124 RPL7 60S ribosomal protein L7 1 31417900.0 12023000.0 10817000.0 8577900.0 True False 9997657.20920967 10758726.673993621 10371499.230271574 1.0 1.0761247809219612 1.037392962495006 23.25315863134747 -10.071286081272818 4.398474832734138 0.9999953322372389 1.0567588717137961 0.7411555070091727 0.01581219867732898 7.238386758188973e-07 1.528269974797357e-07 0.015311354696816732 0.0051033651761731875 8.48621281574043e-11 10.071286081272818 0.05676353947655721 QIFVK(ub)TLTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QIFVKTLTGK 10 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 107496000.0 19906300.0 24003700.0 63586000.0 True False 26097352.07288342 20422441.525689766 57006730.67998132 1.0 0.7825484159716649 2.1843875394245242 24.637400097630604 -6.867281367253019 1.1483057308245295 0.8788118744545155 2.262378966871453 0.9618977230584747 0.12024389646743533 0.13949225536030477 0.3454649203218857 0.08138999899435069 0.1918460277654638 1.357433718286671e-07 6.867281367253019 1.3835670924169376 up QIFVK(ub)TLTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QIFVKTLTGK 10 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 96656100.0 20135300.0 24369800.0 52151000.0 True False 19496115.92300597 34100788.22682812 38491088.60353571 1.0 1.7491067637009803 1.9742952265745988 24.216683398609096 -10.835254150096857 0.2392586506219275 3.29035628544819e-11 2.0977984305028716 0.9992323630754015 0.011539182392689211 2.6994070625012085 0.12550951586431922 1.6349500840535214 0.10911146527537663 1.461321755442719e-11 10.835254150096857 2.097798430469968 QIFVK(ub)TLTGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIFVKTLTGK 10 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 95627100.0 5072100.0 49407000.0 41148000.0 True False 7694746.520179395 40589934.831347115 33015079.764190897 1.0 5.275019095807824 4.2906000447979915 22.875442371497748 -9.732379017403307 6.452083786063767 0.9999999749378878 4.782809570305771 0.951663443089091 0.4018873946850859 1.441804877550276e-07 2.6960714212635737e-08 0.389125796661912 0.12970859888732245 1.851914715281311e-10 9.732379017403307 3.7828095953678833 QIFVK(ub)TLTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QIFVKTLTGK 10 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 91617200.0 19906300.0 21519900.0 50191000.0 True False 27266197.057530247 20569079.661207184 38336919.51609237 1.0 0.7543802173001062 1.40602370896108 24.700610159153495 -6.8045897280443 1.4370006827823543 0.8652533003041346 1.4160810258928684 0.8452437533126178 0.10570622627861871 0.21428730998936685 0.8730400518490008 0.05785536054282886 0.13419815613387742 1.5682318573788678e-07 6.8045897280443 0.5508277255887338 QIFVK(ub)TLTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QIFVKTLTGK 10 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 95976500.0 20135300.0 16932200.0 58909000.0 True False 16743394.095034441 16840982.877821464 71226599.53555861 1.0 1.005828494642909 4.254012008036182 23.997088674043372 -6.90729062866225 0.9139890576156988 0.890611055514766 4.650336891355625 0.9898583180207531 0.1543402819056268 0.10623693364624721 0.14868805608727764 0.12469161647859756 0.3380736564131686 1.237967864612091e-07 6.90729062866225 3.759725835840859 up QIFVK(ub)TLTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIFVKTLTGK 10 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 59894600.0 5072100.0 41006300.0 13816200.0 True False 6565933.4360382985 38724263.35756528 11301793.366183465 1.0 5.89775448301383 1.7212774811501368 22.646568693590197 -6.607291922276815 2.1633464801753406 4.278096942822841 1.7357493282646437 0.04212431921001014 2.1130292781777915 0.620205044088521 5.496120160523308 0.8076249042297735 2.3474492911028624 2.470063269919279e-07 6.607291922276815 -2.542347614558197 QIGFESLK(ub)GADAGNGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIGFESLKGADAGNGIR 17 1 E7EVM7;Q9H5I5-2;Q9H5I5;Q9H5I5-4;J3KRQ5 E7EVM7 PIEZO2 Piezo-type mechanosensitive ion channel component;Piezo-type mechanosensitive ion channel component 2 1 32339500.0 2759500.0 14560000.0 15020000.0 True False 3572227.1478771446 13749723.200731378 12286514.118214559 1.0 3.849061840566992 3.439454886153033 21.76839238962003 -9.881354651795103 6.127203354538628 0.9999996316035812 3.6442583633609105 0.982321645130193 0.16722133890481272 8.452947113702992e-07 1.5435523035518722e-07 0.16191138929791782 0.05397045505860022 1.3141512370511598e-10 9.881354651795103 2.644258731757329 QIGNVAALPGIVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QIGNVAALPGIVHR 14 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 9141600.0 1189400.0 5365000.0 2587200.0 False True 1559314.9181659827 4564562.9126062095 2319501.3621748136 1.0 2.9272874000172493 1.4875130963942411 20.5724808924818 -6.571729324079941 2.2998408702540725 2.318929612132907 1.4906147502900424 0.0 0.8390289038150874 0.724606592275826 7.197228356467234 0.3079689474016479 0.939928862262243 2.6808386485654e-07 6.571729324079941 -0.8283148618428644 QIGNVAALPGIVHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QIGNVAALPGIVHR 14 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 10592300.0 4689300.0 0.0 5903000.0 False True 4540440.738293044 0.0 4356827.21379592 1.0 0.0 0.9595604182324042 22.114400915317862 -11.869631864963502 17.136856279516625 0.8557845347463505 0.5318021882046071 0.0 0.4778423246587085 0.0 0.0 0.0 0.1358169541280907 1.3501068322731495e-12 11.869631864963502 -0.3239823465417434 QIGNVAALPGIVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QIGNVAALPGIVHR 14 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 9406900.0 1189400.0 4620300.0 3597200.0 False True 1629153.322326421 4416159.868711071 2747615.446659509 1.0 2.7107085675673677 1.6865296893824155 20.63569095400469 -10.151534313271076 4.831506635300442 0.999904651676875 2.1986191284806083 0.6461686187131281 0.41811927616790473 0.0004294695581359073 7.541986422853946e-05 0.4048739835421287 0.13494741610774655 7.05449104860636e-11 10.151534313271076 1.1987144768037332 QIGVEHVVVYVNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QIGVEHVVVYVNK 13 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 45662000.0 13193000.0 17738000.0 14731000.0 False True 17296150.76119375 15091559.542182451 13206777.429729892 1.0 0.8725386214857935 0.7635674325504309 24.043947667644115 -6.972947214276617 0.17392546920765709 1.0913370312225756 0.5418397536903982 0.9999971838488013 0.00016204155778258252 0.07535746457793162 0.005448223047242366 0.004430802073879794 0.012463660450619009 1.0642723658792505e-07 6.972947214276617 -0.5494972775321775 QIGVEHVVVYVNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QIGVEHVVVYVNK 13 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 37270000.0 12762000.0 10873000.0 13635000.0 False True 12356877.295565631 15214645.60194595 10063584.458767984 1.0 1.2312694573252623 0.8144116201897857 23.55881087028582 -6.756119345040258 1.6271509803351183 1.134980009352773 0.8131772869299942 0.674911419702955 0.09722561236702386 0.28947920082284223 1.5096307867598129 0.047166725758372545 0.11378435298008133 1.7533985979952094e-07 6.756119345040258 -0.32180272242277885 QIGVEHVVVYVNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIGVEHVVVYVNK 13 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 215839000.0 39238000.0 111260000.0 65341000.0 False True 59526914.68204473 91404783.72165222 52426322.710022315 1.0 1.5355202635627763 0.8807162775032218 25.82703878471119 -6.689350582446481 1.868999256334861 1.3359541211542652 0.8830168790079918 0.3672063267641269 0.22651941776061787 0.41809809179861357 2.831182917485631 0.09698117889324534 0.25272696431627395 2.044793319250447e-07 6.689350582446481 -0.4529372421462734 QIGVEHVVVYVNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QIGVEHVVVYVNK 13 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 49347000.0 13193000.0 16938000.0 19216000.0 False True 18070808.627419293 16189623.153524276 14677576.565942712 1.0 0.8958992089019941 0.8122257763093156 24.107157729167007 -6.973601807598925 0.14880229895888683 1.098914439761115 0.607012074915475 0.9999985896095649 9.103603269052645e-05 0.07515026546576928 0.004543094612814213 0.00432180373820506 0.010489612315485546 1.0626694424032805e-07 6.973601807598925 -0.49190236484564 QIGVEHVVVYVNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QIGVEHVVVYVNK 13 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 23513700.0 12762000.0 4390000.0 6361700.0 False True 10612168.452460602 4366350.198653229 7691902.056822618 1.0 0.41144750181955697 0.7248190689094391 23.339216145720098 -10.084136882431011 5.315325038810044 1.0000058511276362 0.5681332853641031 0.7169001456174249 0.12793340654589988 8.870734887010008e-06 1.5286979751660545e-06 0.1238726654551755 0.0412903294144417 8.238784012535313e-11 10.084136882431011 -0.43187256576353306 QIGVEHVVVYVNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIGVEHVVVYVNK 13 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 151808000.0 39238000.0 69860000.0 42710000.0 False True 50794364.49661299 65972229.58812447 34937218.241607405 1.0 1.2988100204014474 0.6878168195988956 25.598165106803638 -6.773692531622931 1.5600727034887896 1.1705756209386564 0.6838683813194043 0.7445917877158346 0.12607031956162876 0.2604875060678792 1.251618623168876 0.06367498760308825 0.1510806955685483 1.6838657691600656e-07 6.773692531622931 -0.4867072396192521 QIILEK(ub)EETEELKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QIILEKEETEELKR 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 39477500.0 10586100.0 14576700.0 14314700.0 True False 13878479.615938231 12401913.179531572 12833552.160298314 1.0 0.8936074788256381 0.9247087948711681 23.726346193893722 -10.875669237327255 6.839681196788588 1.0128204495291662 0.9091581368484031 0.9191922226683823 0.012697059106763942 0.0027238826579823114 4.951429338027833e-05 0.013490659222656977 0.004097958205525667 1.3314680902645181e-11 10.875669237327255 -0.10366231268076309 QIILEK(ub)EETEELKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QIILEKEETEELKR 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 40218400.0 10300400.0 8878000.0 21040000.0 True False 9973419.440153895 12423031.698158385 15528992.813529778 1.0 1.2456140817804302 1.5570379754619201 23.24965679446594 -6.967899552796358 0.3042033617085186 0.9486169647468852 1.8638520336925708 0.999961051220374 0.0014225268522744465 0.0769903316427317 0.011456856820902892 0.005061941307827544 0.027808378234400234 1.0767142161623446e-07 6.967899552796358 0.9152350689456856 QIILEK(ub)EETEELKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIILEKEETEELKR 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 124886900.0 19817300.0 28944600.0 76125000.0 True False 30064292.93869425 23779209.98480797 61078860.383227214 1.0 0.7909452596572771 2.031608077654661 24.841547693397953 -6.863549410843346 1.1675838526206719 0.8853069643157544 2.095915663784779 0.9578155335383737 0.1113897924586142 0.1431949932017043 0.3689301367868279 0.07429070547705004 0.17418032523418173 1.3691486078350423e-07 6.863549410843346 1.2106086994690246 up QIILEK(ub)EETEELKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QIILEKEETEELKR 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 34730400.0 10586100.0 8092500.0 16051800.0 True False 14500067.24859572 7734946.59168114 12260695.437198129 1.0 0.5334421185136394 0.8455612809923715 23.789556255416613 -9.970965636929341 5.454671619125995 1.0000007568584977 0.6895016997523656 0.5688765151081281 0.1274221145052042 1.1728456403468803e-06 2.214366181824193e-07 0.12337623334724374 0.0411253106177734 1.0691394703544137e-10 9.970965636929341 -0.310499057106132 QIILEK(ub)EETEELKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QIILEKEETEELKR 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 34874300.0 10300400.0 10524600.0 14049300.0 True False 8565238.985090503 10467901.890830474 16986943.67337628 1.0 1.2221377487600675 1.9832422309459694 23.030062069900215 -6.948432021654606 0.5757991530622246 0.9907517020331877 2.2520031277963346 0.9990724316804221 0.012822867518609749 0.08412151729740326 0.03861549909966827 0.013496874728154272 0.06350818396080031 1.1260767153002178e-07 6.948432021654606 1.2612514257631469 QIILEK(ub)EETEELKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIILEKEETEELKR 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 207850900.0 19817300.0 26819600.0 161214000.0 True False 25653885.507383876 25327065.683676835 131874706.19532886 1.0 0.9872604162198755 5.1405353842938055 24.612674015490402 -6.906208659063282 0.9211751309197312 0.8554850997009456 5.635912992074832 0.9894102440702321 0.20116960358786865 0.10697858749631803 0.15276518935137157 0.16167312789969612 0.4353901804944451 1.2410558925111052e-07 6.906208659063282 4.780427892373886 up QIILEKEETEELK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 QIILEKEETEELKR 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 11899000.0 1689400.0 4983800.0 5225800.0 True False 2214819.760172871 4240236.466700246 4685084.345413248 1.0 1.9144837620417867 2.1153343624889676 21.078757867795204 -10.767993340103741 0.30022168281467043 1.4831089889134363e-24 2.1766735653940854 0.9991743196932594 0.013948042330713444 2.4826683946809505 0.15021552851725556 1.858568811823014 0.07208341489172734 1.706108551939366e-11 10.767993340103741 2.1766735653940854 QIILEKEETEELK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 QIILEKEETEELKR 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 25906500.0 10056900.0 6760100.0 9089500.0 True False 9737649.214368746 9459443.183455791 6708687.2708450025 1.0 0.9714298569615306 0.688943206225354 23.21514209973139 -6.926381165931176 0.7759209884933632 1.0049208153926443 0.635955700656732 0.9957779461081379 0.009121834890768654 0.09456095513335465 0.0872081483226736 0.008138030263181373 0.026087247093320397 1.184728494642703e-07 6.926381165931176 -0.3689651147359123 QIILEKEETEELK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIILEKEETEELKR 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 110294700.0 7861700.0 8847000.0 93586000.0 True False 11926773.66725702 7268183.728073501 75088686.07979909 1.0 0.6094006586229681 6.295808755551606 23.507700494021226 -6.8904432692268625 1.0197827375172905 0.6977004793369984 6.789113787501288 0.9811795726885624 0.3557877590202459 0.11878319591140286 0.21976552011983705 0.26568297212231323 0.6634013176700211 1.286935351111084e-07 6.8904432692268625 6.091413308164289 up QIILEKEETEELK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QIILEKEETEELKR 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 10129200.0 1689400.0 1752800.0 6687000.0 True False 2314016.83431836 1675355.5002655173 5107668.323087996 1.0 0.7240031599679467 2.207273623656486 21.141967929318096 -6.858623608261242 1.1925924575159816 0.8507554252950742 2.277260222575769 0.9519475189688089 0.1411922086916269 0.14823448966750408 0.4013911041270907 0.09238524697447797 0.2153427031490769 1.3847659997540913e-07 6.858623608261242 1.4265047972806948 up QIILEKEETEELK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QIILEKEETEELKR 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 27597100.0 10056900.0 11692400.0 5847800.0 True False 8362757.946211485 11629410.720440306 7070547.942827746 1.0 1.3906190750993441 0.845480401119449 22.995547375165668 -6.714362493043052 1.7796503772351093 1.2390639676637145 0.8465881051193936 0.485822419814963 0.16449683537517726 0.3663597673366467 2.2644201277985156 0.07348390866423433 0.18570305186260114 1.9303564317311488e-07 6.714362493043052 -0.3924758625443209 QIILEKEETEELK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIILEKEETEELKR 14 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 261673700.0 7861700.0 32751000.0 221061000.0 True False 10177125.627275148 30928378.059557185 180830166.2774054 1.0 3.0390091654826152 17.768294595162757 23.278826816113675 -6.93204674680731 0.7297995779777191 0.7921439207215419 20.955991222244158 0.9969253711623395 0.41423829528932743 0.09158901337499895 0.07257625360103412 0.38209331491414994 1.3180682496014349 1.1693735146324274e-07 6.93204674680731 20.163847301522615 QIK(ub)QVEDDIQQLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIKQVEDDIQQLLK 14 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 86692000.0 13132000.0 30307000.0 43253000.0 True False 19922204.077797286 24898479.06032819 34704025.59153665 1.0 1.2497853632609264 1.7419772157746978 24.247873931908863 -6.960335400828735 0.43068895430511656 0.9805916385780873 2.0300669058107177 0.9997824166118089 0.004546937115939337 0.07958164061717186 0.020690958068381088 0.0064223410997782115 0.04086061610360792 1.0956317250523222e-07 6.960335400828735 1.0494752672326304 QIK(ub)QVEDDIQQLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIKQVEDDIQQLLK 14 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 72928000.0 13132000.0 29422000.0 30374000.0 True False 16999632.870419502 27784639.835983396 24846243.663558498 1.0 1.6344258754158465 1.4615753088875598 24.019000254001313 -10.08239021362495 4.459595448451302 0.9999615997106066 1.548000592030748 0.9305636457779465 0.07056594848931565 24517177.67976201 1.0232989674059398 11158.09934065598 0.024156601081670708 8.27198591715174e-11 10.08239021362495 0.5480389923201414 QIKPYTLMSMVANLLYEK ddPTM_RPMI8226_Bortezomib_8h_R1 3 QIKPYTLMSMVANLLYEK 18 1 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 6348241300.0 2351261300.0 1948178000.0 2048802000.0 False True 3567035292.326153 1600510414.7158096 1643855386.6781833 1.0 0.4486948638156245 0.4608464037949521 31.732078343918275 -9.95970730367766 5.281656948760886 1.0000016063817914 0.45477063380236316 0.999627604644128 0.00496084543365239 1.0201242042587607e-07 2.0090407394257445e-08 0.004803333318721579 0.001601105977438893 1.0972174256790075e-10 9.95970730367766 -0.5452309725794282 QIKPYTLMSMVANLLYEK ddPTM_RPMI8226_Carfilzomib_8h_R1 3 QIKPYTLMSMVANLLYEK 18 1 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 5463378300.0 2351261300.0 1941310000.0 1170807000.0 False True 3043754103.1393065 1833274391.9513595 957732139.4943019 1.0 0.6023069965016337 0.3146548988653531 31.503204666010724 -8.00481585233964 0.22225508041171516 1.2153385879670213 4.351450355315781e-15 0.9997557617690307 0.004391351597067922 0.10178962857982167 0.039732886241277306 0.07400406325241457 0.09995240439056945 9.889723455256824e-09 8.00481585233964 -1.2153385879670169 down QIKPYTLMSMVANLLYEKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIKPYTLMSMVANLLYEKR 19 2 P49720;A0A087WXQ8;A0A087WY10;A0A087WUL2 P49720 PSMB3 Proteasome subunit beta type-3 0 516220000.0 116690000.0 183320000.0 216210000.0 False True 151057505.3037811 173118080.84876868 176861998.50194183 1.0 1.1460409100535793 1.170825627937302 27.170522625359716 -13.975876622721984 0.24962693964212018 1.7837842127236813e-11 1.1808581893512993 0.9995400761433587 0.0016163289965601178 13.814119139925543 0.15796916518715642 6.922745834511027 0.011471880202925838 1.0571177796418532e-14 13.975876622721984 1.1808581893334615 QILLYSATFPLSVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QILLYSATFPLSVQK 15 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 25203600.0 5392500.0 13498000.0 6313100.0 False True 7069619.721044285 11484151.014791911 5659880.971531316 1.0 1.6244368817472314 0.8005919971456781 22.753201183040776 -6.704081755420626 1.8169898366721073 1.3862045275471593 0.802900720948513 0.436687210691601 0.26339217013240035 0.387076189420629 2.487329364376519 0.11554252449847856 0.29558239413532666 1.9765975129515054e-07 6.704081755420626 -0.5833038065986463 QILLYSATFPLSVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QILLYSATFPLSVQK 15 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 32885500.0 13252000.0 8519500.0 11114000.0 False True 12831322.51377807 11921380.778605575 8202909.987146862 1.0 0.9290843376280649 0.6392879594709515 23.613166539685007 -6.9443838637637825 0.6174390804966393 1.0031780946076412 0.549908756967733 0.9986834932417347 0.005661547906980437 0.08582251936934505 0.045922228257175235 0.005715005650010993 0.024502068319765497 1.1366222052283997e-07 6.9443838637637825 -0.4532693376399082 QILLYSATFPLSVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QILLYSATFPLSVQK 15 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 36806500.0 5392500.0 11830000.0 19584000.0 False True 7386252.976833057 11307311.48342142 14958662.545140622 1.0 1.5308589509304302 2.025203116121041 22.816411244563668 -6.971982720558539 0.20537863856238792 0.7254230398490211 2.8443683919331715 0.999993996590261 0.0010256949293546273 0.07566441279292613 0.0066759152152818645 0.015361298703977355 0.051788176161702455 1.0666385591442929e-07 6.971982720558539 2.1189453520841504 QILLYSATFPLSVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QILLYSATFPLSVQK 15 0 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 26629300.0 13252000.0 6798500.0 6578800.0 False True 11019625.163141191 6761875.131103403 7954396.663065624 1.0 0.6136211559827596 0.7218391320307115 23.393571815119284 -10.267220608076812 8.103454832810456 1.0000003832182984 0.6677301440067369 0.9263059141832959 0.04417980371903564 3.058864208451593e-07 2.7688726247893816e-08 0.04277696009024446 0.014258970336878134 5.404797063379629e-11 10.267220608076812 -0.3322702392115615 QILMENAELK(ub)K(ub)VLQQMK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 QILMENAELKKVLQQMK 17 2 S4R403;Q9Y2D8-2;Q9Y2D8-3;Q9Y2D8 S4R403 SSX2IP Afadin- and alpha-actinin-binding protein 3 53670000.0 13055000.0 21605000.0 19010000.0 True False 17115231.42479982 18381618.215630382 17043027.556796234 1.0 1.0739918006013978 0.9957813092787655 24.028777464193162 -6.658740936887869 1.9776584259429546 1.0476785231075536 0.9961103344814899 0.2301008776297282 0.031513871263845396 0.4874641484102643 3.6638026436037183 0.012880993523709909 0.03492334469287902 2.1941133662902173e-07 6.658740936887869 -0.051568188626063716 QILMENAELK(ub)K(ub)VLQQMK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 QILMENAELKKVLQQMK 17 2 S4R403;Q9Y2D8-2;Q9Y2D8-3;Q9Y2D8 S4R403 SSX2IP Afadin- and alpha-actinin-binding protein 3 56752000.0 20571000.0 18346000.0 17835000.0 True False 19917984.864996083 25671653.473126102 13163478.46146881 1.0 1.2888680078395647 0.6608840477935266 24.24756835919101 -6.781594680861276 1.5293636445407357 1.163220322996515 0.6556307186482586 0.7731175437837638 0.12224646430098782 0.24808764358011046 1.1461826987713208 0.06294688603198799 0.1483497666006624 1.653504263786279e-07 6.781594680861276 -0.5075896043482564 QILMENAELK(ub)K(ub)VLQQMK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QILMENAELKKVLQQMK 17 2 S4R403;Q9Y2D8-2;Q9Y2D8-3;Q9Y2D8 S4R403 SSX2IP Afadin- and alpha-actinin-binding protein 3 63694000.0 13055000.0 28740000.0 21899000.0 True False 17881786.298109487 27470171.769529283 16726907.224062208 1.0 1.5362095996211245 0.9354159000228419 24.091987525716053 -6.6713616890913885 1.9326526303316922 1.3418639562897048 0.9378362693619363 0.2850245488525963 0.2276998728844309 0.4580123874817893 3.2994759664805318 0.0948079415160932 0.2528443024600787 2.1312692103966433e-07 6.6713616890913885 -0.40402768692776847 QILMENAELK(ub)K(ub)VLQQMK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QILMENAELKKVLQQMK 17 2 S4R403;Q9Y2D8-2;Q9Y2D8-3;Q9Y2D8 S4R403 SSX2IP Afadin- and alpha-actinin-binding protein 3 51031000.0 20571000.0 19685000.0 10775000.0 True False 17105697.949817155 19578952.997833434 13028002.682028968 1.0 1.144586619924662 0.7616177206126936 24.027973634625287 -6.804399286116622 1.4377258442190206 1.0793347513529612 0.7557286529502855 0.8447650942491027 0.06221305832544357 0.2145307509661328 0.8749316777874542 0.03403372653865678 0.0789531877902421 1.5689196915601904e-07 6.804399286116622 -0.32360609840267573 QILSK(ub)IPDEINDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QILSKIPDEINDR 13 1 Q9BUL8;C9J363;C9J5C3;C9J6F3;C9JND6;H7C5M9;C9JSA3 Q9BUL8 PDCD10 Programmed cell death protein 10 1 7069760.0 567260.0 4302900.0 2199600.0 True False 743683.3533536548 3660924.0925728306 1972006.4920530773 1.0 4.922691997963677 2.6516749140077898 19.504328953584196 -9.490610787512336 8.403216889311674 1.0000000360594568 3.787183455881079 0.6675865778436765 0.9271388421395577 0.0 0.0 0.8976983238069813 0.29923277460232706 3.23138877848366e-10 9.490610787512336 2.787183419821622 QILSK(ub)IPDEINDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QILSKIPDEINDR 13 1 Q9BUL8;C9J363;C9J5C3;C9J6F3;C9JND6;H7C5M9;C9JSA3 Q9BUL8 PDCD10 Programmed cell death protein 10 1 6745660.0 567260.0 3294800.0 2883600.0 True False 776991.3516250945 3149224.8415534175 2202553.069606183 1.0 4.053101537059254 2.834720187038755 19.567539015107087 -8.955735815053144 11.96128615467847 1.000000000003756 3.4439108620486487 0.8428826517850767 0.49740210328261336 0.0 0.0 0.48160751559385934 0.16053583853128642 1.1072971572215484e-09 8.955735815053144 2.4439108620448926 QILVDEAGMATEPETLIPLVQFPQAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QILVDEAGMATEPETLIPLVQFPQAEK 27 0 Q9BYK8-2;Q9BYK8-4;Q9BYK8 Q9BYK8-2 HELZ2 Helicase with zinc finger domain 2 0 31349100.0 8174000.0 8606100.0 14569000.0 False True 12400555.599445274 7070274.215233794 11689430.764180455 1.0 0.5701578577293808 0.9426537924400235 23.563901425356544 -10.170264117471811 7.662741300880364 1.0000001068108775 0.7564058250847021 0.363139649627939 0.1520708285503586 2.774346974010261e-07 3.006472067949197e-08 0.14724201023257252 0.04908064886829189 6.756719385330673e-11 10.170264117471811 -0.24359428172617537 QILVDEAGMATEPETLIPLVQFPQAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QILVDEAGMATEPETLIPLVQFPQAEK 27 0 Q9BYK8-2;Q9BYK8-4;Q9BYK8 Q9BYK8-2 HELZ2 Helicase with zinc finger domain 2 0 18604200.0 8174000.0 5512500.0 4917700.0 False True 10581404.133628488 5205724.529123051 4022729.059863091 1.0 0.4919691624459246 0.3801696834429147 23.335027747448994 -13.999999999999943 0.21273361193656418 3.9716389938745227 0.31603879298449133 0.9994917220231766 0.006081045468697452 12.812071146602797 0.1461708656233383 15.93471286318797 0.06497860948606636 1.000000000000131e-14 13.999999999999943 -3.6556002008900315 QIMK(ub)EIQEHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QIMKEIQEHK 10 1 E7ES33;E7EPK1;Q16181-2;Q16181;G3V1Q4 E7ES33 SEPT7 Septin-7 1 4222580.0 644580.0 1420200.0 2157800.0 True False 845050.6221216001 1208311.695896241 1934531.555079166 1.0 1.4298690093412758 2.2892493117421706 19.688678241981073 -6.960052920870397 0.4346866580841818 0.9675133163246472 2.784817180668979 0.9997721587635814 0.00809032308750154 0.07968221482154897 0.02106144058365323 0.011260210589543358 0.0712809742503974 1.0963445931441517e-07 6.960052920870397 1.817303864344332 up QIMK(ub)EIQEHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QIMKEIQEHK 10 1 E7ES33;E7EPK1;Q16181-2;Q16181;G3V1Q4 E7ES33 SEPT7 Septin-7 1 9148200.0 2655900.0 2096000.0 4396300.0 True False 2571589.908266159 2932943.730495607 3244777.143827039 1.0 1.1405176700483646 1.2617786115107141 21.29422916359095 -6.972845119336984 0.1775216322761358 0.9031228482139821 1.5024445260760786 0.9999969126000499 0.00018786302510704424 0.07538980798236496 0.005582945680200095 0.004773622916068881 0.013712285104523294 1.0645225868701307e-07 6.972845119336984 0.5993216778620964 QIMK(ub)EIQEHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QIMKEIQEHK 10 1 E7ES33;E7EPK1;Q16181-2;Q16181;G3V1Q4 E7ES33 SEPT7 Septin-7 1 8479200.0 2655900.0 3001800.0 2821500.0 True False 2208498.5263195485 2985628.707589354 3411462.6048579733 1.0 1.3518816843246388 1.5446977048896466 21.074634439025225 -10.973379001439941 0.10462498348278226 5.673495750290452e-17 2.007292450358487 0.9998750245578124 0.002521028250839117 3.287546677222615 0.0632760092355951 1.0944700369887561 0.30174752335898514 1.0632147637275903e-11 10.973379001439941 2.007292450358487 QINIHNLSAFYDSELFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QINIHNLSAFYDSELFR 17 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 7990400.0 3679100.0 0.0 4311300.0 False True 4823335.728455078 0.0 3865208.0329098147 1.0 0.0 0.8013557941047258 22.20159980175865 -9.751832078392667 10.799576541888188 0.9999999961587528 0.4006778970523629 0.4271889162379 0.3271521329965657 0.0 0.0 0.3167636930530567 0.10558789689766104 1.7707935099882992e-10 9.751832078392667 -0.5993220991063899 QINIHNLSAFYDSELFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QINIHNLSAFYDSELFR 17 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 67155000.0 16985000.0 22656000.0 27514000.0 False True 16445820.472118951 31702658.94947922 20307257.997692883 1.0 1.9277030904736923 1.2347974995908737 23.971217649370555 -10.185205427713747 4.643136035996145 0.9999098840530086 1.5812502950336247 0.48406976490233833 0.2828775229664415 0.00028043952018141075 4.9212471279889634e-05 0.27393980695852516 0.0912983279502375 6.52821685290553e-11 10.185205427713747 0.5813404109806161 QINIHNLSAFYDSELFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QINIHNLSAFYDSELFR 17 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 14669100.0 3679100.0 0.0 10990000.0 False True 5039362.693939077 0.0 8394388.346154783 1.0 0.0 1.665763878486232 22.264809863281542 -6.7441628290878395 1.6716313058914147 0.4078712256808681 1.6676148282405916 0.6233611522185865 0.42014107985146654 0.31035943923999443 1.70439274350613 0.19871466642384283 0.48538443419025207 1.802341866039936e-07 6.7441628290878395 1.2597436025597235 QINIHNLSAFYDSELFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QINIHNLSAFYDSELFR 17 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 51617000.0 16985000.0 13628000.0 21004000.0 False True 14123780.063081268 13554583.259053797 25395839.28847665 1.0 0.9596994004802355 1.7980908209452993 23.75162292480483 -6.895611423693591 0.9886168581156037 0.9608225632028405 1.8786484099169156 0.984252815426463 0.04844748233228415 0.11470752571201524 0.19620684677312053 0.037037045578131554 0.09440611836446233 1.2717114347167467e-07 6.895611423693591 0.9178258467140751 QININNPFVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QININNPFVFK 11 0 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 9954500.0 2595200.0 2992300.0 4367000.0 False True 3402332.331952547 2545860.503894042 3915144.731221947 1.0 0.748269203447569 1.1507237827573136 21.69809263632287 -6.737592976117206 1.6953848615494171 0.8498009938915135 1.1508418341684263 0.5940621458256272 0.10577503121180186 0.3222289352958754 1.817609590593067 0.04937415164234324 0.12148715935135378 1.8298143278039157e-07 6.737592976117206 0.3010408402769128 QININNPFVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QININNPFVFK 11 0 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 8430300.0 3045500.0 1199200.0 4185600.0 False True 2948822.269522414 1678046.813745386 3089265.7946915478 1.0 0.5690566132414482 1.047626988788266 21.491707440687666 -6.669467277813618 1.9392232777923177 0.7247975205164172 1.0456868639936958 0.2766060094948317 0.18307940809165557 0.46240425461859747 3.3519379947289845 0.07601701795057501 0.20324241626540065 2.1405862044874532e-07 6.669467277813618 0.3208893434772786 QININNPFVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QININNPFVFK 11 0 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 9541600.0 2595200.0 2933200.0 4013200.0 False True 3554715.572642954 2803601.5252047107 3065364.814448445 1.0 0.7886992553725515 0.8623375771719836 21.76130269784576 -10.60944161802705 9.020398543030915 1.0000523307949503 0.8255184176005232 0.8821541395817963 0.030062718987245985 3.164777304316834e-05 1.3702765371741438e-06 0.029116798145123374 0.009702700831609776 2.4578670187452296e-11 10.60944161802705 -0.17453391319442702 QININNPFVFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QININNPFVFK 11 0 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 6454000.0 3045500.0 1299300.0 2109200.0 False True 2532468.1885259906 1292300.413009141 2550223.968161066 1.0 0.5102928514025353 1.0070112547575218 21.272112716121942 -10.793872495824377 11.067961765090962 1.0012625025708615 0.7586520530800301 0.2394157763385346 0.2027844390116128 0.006343862717957618 0.00011814655913771617 0.19716839091938207 0.0654483962634992 1.6074131028940554e-11 10.793872495824377 -0.24261044949083133 QINWTVLYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QINWTVLYR 9 0 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 131078000.0 40251000.0 44676000.0 46151000.0 False True 52769450.79123842 38010514.94568403 41375737.23165196 1.0 0.7203128775407893 0.7840850456325346 25.653199632679463 -10.113975982514834 7.137586161150453 1.0000001174978956 0.7521989615866623 0.9526779532690397 0.026034878602629197 4.869030499264855e-08 6.0258156900484734e-09 0.0252081748322265 0.008402720937376219 7.691729761476616e-11 10.113975982514834 -0.2478011559112333 QINWTVLYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QINWTVLYR 9 0 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 132964000.0 60710000.0 23336000.0 48918000.0 False True 58782794.280973844 32654186.49563234 36104908.29145674 1.0 0.5555058566891142 0.6142087788287187 25.808890604342107 -10.27581051908814 5.575222900611306 1.000038078480395 0.5848573177591614 0.9852252048221879 0.023965367608761553 1.1344036861439469e-05 1.4735099381291202e-06 0.023206490294437443 0.007734789136200968 5.29894584311965e-11 10.27581051908814 -0.41518076072123367 QINWTVLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QINWTVLYR 9 0 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 115308000.0 40251000.0 30215000.0 44842000.0 False True 55132882.44237496 28880001.392356556 34251243.149979316 1.0 0.5238253491016366 0.6212489104987176 25.716409694202355 -10.027155026410906 5.892412830919076 1.0000007915788676 0.5725371298001213 0.9625031620819616 0.03977300239145767 4.1359573981650625e-07 6.826853493243668e-08 0.03851011512483076 0.01283668132420298 9.393879253828689e-11 10.027155026410906 -0.4274636617787463 QINWTVLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QINWTVLYR 9 0 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 104647000.0 60710000.0 21618000.0 22319000.0 False True 50483054.909017555 21501539.543162975 26985799.70860367 1.0 0.4259159748140015 0.5345516383118748 25.589295879776383 -9.964659036142907 5.917987109833845 1.0000003878587111 0.4802338065631373 0.968275909336885 0.044350323906915345 2.2697014812146138e-07 3.9736217960363685e-08 0.042942048785392234 0.014314005490792378 1.084778237335378e-10 9.964659036142907 -0.5197665812955738 QIPAITCIQSQWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QIPAITCIQSQWR 13 0 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 9907500.0 2381400.0 2899600.0 4626500.0 False True 3122038.461510403 2466990.982552277 4147794.1605217187 1.0 0.790185967586952 1.3285531910183668 21.574056879826585 -6.801028882048961 1.451878528201751 0.8843878070266046 1.3361607586599558 0.8351107695756674 0.08996878839141241 0.21929125850858625 0.9125229830832404 0.04874875128058183 0.11329266501474258 1.5811428844350544e-07 6.801028882048961 0.4517729516333512 QIPAITCIQSQWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QIPAITCIQSQWR 13 0 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 6934200.0 2381400.0 1870200.0 2682600.0 False True 3261867.934915202 1787568.3800756317 2049025.1298812395 1.0 0.5480198511231579 0.6281753801091605 21.637266941349477 -10.793854490593771 7.15724139052844 1.0137835515101292 0.5880976156161593 0.9723829695931758 0.0327233576797622 0.007073245582137573 0.00020372599224187195 0.031138358334551707 0.01056141827714229 1.6074797453331258e-11 10.793854490593771 -0.42568593589396997 QIPVLQTNNGPSLTGLTTIAAHLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QIPVLQTNNGPSLTGLTTIAAHLVK 25 0 O43324;D6RBD7;C9J1V9;O43324-2;H0YAL7 O43324 EEF1E1;EEF1E1-BLOC1S5 Eukaryotic translation elongation factor 1 epsilon-1 0 248188000.0 79187000.0 51381000.0 117620000.0 False True 76673252.02977231 71897701.24837528 86811793.47563559 1.0 0.9377155571861922 1.132230486870786 26.192220036017176 -6.820544797063542 1.3694594073648885 0.966447084178809 1.1365286818423488 0.8856417940167376 0.0274267532273841 0.19277579777084516 0.7102400428373111 0.015737255711248274 0.0362676818232661 1.5116637646363622e-07 6.820544797063542 0.1700815976635398 QIPVLQTNNGPSLTGLTTIAAHLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QIPVLQTNNGPSLTGLTTIAAHLVK 25 0 O43324;D6RBD7;C9J1V9;O43324-2;H0YAL7 O43324 EEF1E1;EEF1E1-BLOC1S5 Eukaryotic translation elongation factor 1 epsilon-1 0 205521000.0 79187000.0 40363000.0 85971000.0 False True 65847499.07890585 40145556.50757174 103947138.61500806 1.0 0.6096747343352378 1.5786042001450495 25.972625311451452 -6.797373743088018 1.4667331725645418 0.7839179273848541 1.5911099358278318 0.8243379503566879 0.16682899486161656 0.2245290199411694 0.953890404011787 0.08949448023156915 0.20846176761887358 1.5945063638961702e-07 6.797373743088018 0.8071920084429777 QIPVLQTNNGPSLTGLTTIAAHLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIPVLQTNNGPSLTGLTTIAAHLVK 25 0 O43324;D6RBD7;C9J1V9;O43324-2;H0YAL7 O43324 EEF1E1;EEF1E1-BLOC1S5 Eukaryotic translation elongation factor 1 epsilon-1 0 32965100.0 14246000.0 10338000.0 8381100.0 False True 18441727.830642432 9762681.21216764 6855825.797348064 1.0 0.5293799638418993 0.37175615323617084 24.136470494378024 -13.999999999999998 0.15279951268779848 3.2860149724592325 0.20379877906768668 0.9995571656162142 0.00561609662896409 11.969332035823458 0.12324512982268539 8.118069080492514 0.1518141478586571 1.0000000000000041e-14 13.999999999999998 -3.0822161933915457 QIQELVEAIVLPMNHK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIQELVEAIVLPMNHKEK 18 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 40096000.0 13406000.0 14779000.0 11911000.0 True False 20337882.109880477 12141571.981145965 9556785.629223246 1.0 0.5969929373937806 0.46990072897415425 24.27766611584264 -13.999999999999998 0.1615291287371407 2.9913024403432464 0.3470470424299388 0.9995324290724026 0.004886288916502308 12.0202172494177 0.12705849366571764 7.498411604100245 0.11218891465850699 1.0000000000000041e-14 13.999999999999998 -2.644255397913308 QIQELVEAIVLPMNHK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIQELVEAIVLPMNHKEK 18 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 47266200.0 13406000.0 13023000.0 20837200.0 True False 17354331.27176697 12298258.601862952 17045043.407727055 1.0 0.7086564390914024 0.9821780592293358 24.048792437935088 -10.528393920945563 8.489668918014498 1.0000153243322616 0.8454172492989082 0.29867399959038043 0.11166473382621742 3.239166079791106e-05 1.7993905190178301e-06 0.10812962186047755 0.03603963787230202 2.962143398483658e-11 10.528393920945563 -0.15459807503335343 QIQELVEAIVLPMNHKEK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 QIQELVEAIVLPMNHKEK 18 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 31439700.0 8129500.0 16746000.0 6564200.0 True False 10657853.226189978 14247562.075396756 5884999.552252603 1.0 1.3368135001508221 0.5521749481209924 23.345413534594584 -6.7900657500578125 1.4961823583113787 1.1882278358013814 0.5438275416621312 0.8015082018329908 0.14318890250233254 0.2352510303748409 1.0403807033756653 0.07533087963620533 0.17635107746831355 1.6215645818376148e-07 6.7900657500578125 -0.6444002941392502 QIQELVEAIVLPMNHKEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 2 QIQELVEAIVLPMNHKEK 18 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 79376600.0 32008100.0 30592200.0 16776300.0 True False 30992020.38584811 42807824.99621547 12382083.751787996 1.0 1.3812531246192266 0.3995248969777404 24.88539347223773 -6.801409909645326 1.4503284783289485 1.2099758211635532 0.38552061676516053 0.8362179786036378 0.16354164573701405 0.2187429529548441 0.9082572716507707 0.08870716431574739 0.20610896096230946 1.5797562795117574e-07 6.801409909645326 -0.8244552043983926 down QIQELVEAIVLPMNHKEK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIQELVEAIVLPMNHKEK 18 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 83274000.0 28425000.0 37025000.0 17824000.0 True False 43122803.14585654 30417599.472354632 14301078.587463275 1.0 0.7053715726566192 0.33163610767815765 25.361947626002856 -7.051078414280442 0.31740253421174686 1.0557264802944193 2.164830632109638e-16 0.999953015329283 0.0018746708526521402 0.07298539226253974 0.01243951826638206 0.006093855789544718 0.03170993548215915 8.890405821514286e-08 7.051078414280442 -1.055726480294419 down QIQELVEAIVLPMNHKEK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QIQELVEAIVLPMNHKEK 18 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 45015600.0 14538400.0 16406200.0 14071000.0 True False 19913639.365487207 15681319.835951688 10747719.60134158 1.0 0.7874662962476537 0.539716493006733 24.24725357259932 -6.969108601780888 0.27865509776944136 1.0554718215202403 0.26417534308721924 0.9999745700368816 0.0009485012366003733 0.07659302467786482 0.010061178175312132 0.004611982643321394 0.02277918216332082 1.0737208789255947e-07 6.969108601780888 -0.7912964784330211 QIQELVEAIVLPMNHKEK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QIQELVEAIVLPMNHKEK 18 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 58529100.0 17830000.0 30765000.0 9934100.0 True False 14826435.00292841 30599262.83862565 12011274.379911272 1.0 2.0638314492042023 0.8101255883520814 23.821668409550625 -6.6818903107947065 1.89546445721775 1.6719608935178745 0.8148558916766122 0.3326995905686202 0.45069266049509826 0.4343171773595805 3.018584859138427 0.19069232085429386 0.5016695249562396 2.0802220197911148e-07 6.6818903107947065 -0.8571050018412623 QIQELVEAIVLPMNHKEK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIQELVEAIVLPMNHKEK 18 1 E9PMD8;P17980;R4GNH3;E9PM69;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 20912300.0 8571900.0 7783300.0 4557100.0 True False 11096493.52741008 7350152.51292942 3727754.559794644 1.0 0.6623851484951881 0.3359398670027162 23.40360052368659 -7.334987263113108 0.26452866480569676 1.1068802352849874 6.586774422375933e-17 0.9999104033020775 0.0025662393680760615 0.11004726687021507 0.019023883656990703 0.016576317862887827 0.05104866587295257 4.623945822004602e-08 7.334987263113108 -1.1068802352849874 down QIQITQLFGVPVVVALNVFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIQITQLFGVPVVVALNVFK 20 0 A0A087WVM4;B7ZM99;Q6UB35;Q4VXV2 A0A087WVM4 MTHFD1L Monofunctional C1-tetrahydrofolate synthase, mitochondrial 0 827480000.0 319460000.0 281010000.0 227010000.0 False True 484644175.6543656 230861569.95884866 182141373.9979822 1.0 0.47635271722215544 0.3758249518877541 28.85235067254021 -13.99999999999996 0.23205633116537458 4.337399523319502 0.327894079683538 0.9995126700215937 0.006040738420415521 13.356158138232527 0.1525129083517671 20.561909988859583 0.051523425470964924 1.000000000000094e-14 13.99999999999996 -4.009505443635964 QIQLAQK(ub)LEIMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QIQLAQKLEIMR 12 1 O14964;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 5380500.0 1568500.0 2269000.0 1543000.0 True False 1518708.8260534916 3175023.5326786838 1138842.0109922267 1.0 2.0906071514243334 0.74987515148089 20.534413865447593 -6.690393577609401 1.8648332019697693 1.683511937270802 0.7544756998927954 0.37220242197653153 0.46121810750416176 0.4159076068547705 2.804501588467629 0.19782363057091437 0.5149260055442036 2.039888466121885e-07 6.690393577609401 -0.9290362373780067 QIQLAQK(ub)LEIMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIQLAQKLEIMR 12 1 O14964;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 37352200.0 5904200.0 0.0 31448000.0 True False 8957103.054837875 0.0 25232289.015851937 1.0 0.0 2.8170144812862876 23.094600774351754 -6.810756229348673 1.4115033919116085 0.45550653239107375 2.867080787357643 0.8617569327288899 0.433550705301223 0.20577206532110745 0.8078926015749799 0.24151643768925965 0.5584486131457647 1.546122038447854e-07 6.810756229348673 2.4115742549665695 QIQLAQK(ub)LEIMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QIQLAQKLEIMR 12 1 O14964;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 8051400.0 1505900.0 2468800.0 4076700.0 True False 2062671.9254173203 2359720.252770147 3113867.4222719967 1.0 1.144011426971222 1.509628062466598 20.976082943523686 -6.955130656345974 0.49935221210833003 0.9926365450904445 1.676754943813225 0.999544828633113 0.004576538683983028 0.08148861921590944 0.027924835269858308 0.005373659181866002 0.030159429059397135 1.1088411731436935e-07 6.955130656345974 0.6841183987227805 QIQLAQK(ub)LEIMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QIQLAQKLEIMR 12 1 O14964;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 19477900.0 5335900.0 8289400.0 5852600.0 True False 4437037.270450119 8244743.356882921 7076351.600635048 1.0 1.858164097874825 1.5948370881989868 22.081165240955993 -10.15609098647364 4.73172746575698 0.9999342852386964 1.7265005929517425 0.9103052203275666 0.10750280165321426 8.370840264064856e-05 1.4929616363290992e-05 0.10409964679863436 0.034696380021538645 6.980861368495808e-11 10.15609098647364 0.7265663077130461 QIQLAQK(ub)LEIMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 QIQLAQKLEIMR 12 1 O14964;I3L1E3 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 52027600.0 8298300.0 22684300.0 21045000.0 True False 10742312.933947774 21421898.763897676 17215025.939935103 1.0 1.994160745047778 1.6025437022535727 23.356801318529282 -10.083157683110894 4.464212548001421 0.9999374004700466 1.7983522236850467 0.84712309681458 0.15987698840430387 37034206.89344155 3.338122091247033 24534.60353583747 0.054730145584510066 8.257380871658823e-11 10.083157683110894 0.798414823215 QIQSLCFQVNNLLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QIQSLCFQVNNLLEK 15 0 D6RFN0;Q9BT78;D6RD63 D6RFN0 COPS4 COP9 signalosome complex subunit 4 0 9135700.0 3415900.0 3359400.0 2360400.0 False True 4478277.979622657 2858190.6148386365 2116168.4505555956 1.0 0.6382343007388455 0.4725406641089987 22.094512652533883 -13.99999999999772 0.10494685681889097 2.763559375258693 0.14521234402297223 0.9997687458835705 0.0033491602602272793 12.044775402790174 0.09744030354428244 4.547042447096132 0.291223468277 1.0000000000052518e-14 13.99999999999772 -2.6183470312357207 QIQSLCFQVNNLLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QIQSLCFQVNNLLEK 15 0 D6RFN0;Q9BT78;D6RD63 D6RFN0 COPS4 COP9 signalosome complex subunit 4 0 14290300.0 3415900.0 2743900.0 8130500.0 False True 4678850.541226527 2622665.425136097 6210243.352903682 1.0 0.5605362689034696 1.3273010749507104 22.157722714056774 -6.751258395001719 1.645060672590892 0.741981345368806 1.328983313213781 0.6543989256181433 0.18467896222918637 0.2978661665586609 1.586343210096823 0.08866599847775543 0.21498416387562677 1.7731341938462507e-07 6.751258395001719 0.5870019678449749 QISQAYEVLSDAKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QISQAYEVLSDAKK 14 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 308136000.0 79276000.0 118480000.0 110380000.0 True False 102624344.76358333 111886483.84770969 90291972.59444216 1.0 1.090252845028766 0.8798299546023766 26.612797769805056 -6.790135772399669 1.4956333665727635 1.0504331357829662 0.8775786488201227 0.8018146919006803 0.03837172505600258 0.2351471108166639 1.0391142902371566 0.020193321290602115 0.04727604111219486 1.6213031541633346e-07 6.790135772399669 -0.17285448696284345 QISQEHTPVALEAYFVPLVK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 QISQEHTPVALEAYFVPLVKR 21 1 P30154;P30154-2;P30154-4;P30154-3 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 9928400.0 1589500.0 2810300.0 5528600.0 True False 2083849.8927398964 2391014.1944636037 4956553.506075943 1.0 1.1474023166418383 2.378555923507017 20.990819928130936 -6.929302626799498 0.7524944123083351 0.9807860420406187 2.6268748472527603 0.9963994547076702 0.037085866495562426 0.0930013059601429 0.07946579457323052 0.03364805720107559 0.11182815013815979 1.1767856753011572e-07 6.929302626799498 1.6460888052121416 up QISQEHTPVALEAYFVPLVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 QISQEHTPVALEAYFVPLVKR 21 1 P30154;P30154-2;P30154-4;P30154-3 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 32920300.0 3069100.0 3986200.0 25865000.0 True False 2971673.1004404034 5577910.447758388 19090180.56663249 1.0 1.8770269337269092 6.424051341247231 21.502843989940697 -6.938999719830797 0.6688037464070014 0.9479726151955417 7.6149832270482625 0.9980299393087564 0.10551830745180692 0.08822591948615544 0.05670989810979176 0.10195188683324657 0.39310941268174604 1.1508011313414627e-07 6.938999719830797 6.667010611852721 QISQEHTPVALEAYFVPLVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 QISQEHTPVALEAYFVPLVKR 21 1 P30154;P30154-2;P30154-4;P30154-3 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 162084300.0 4926300.0 14779000.0 142379000.0 True False 7473557.260771614 12141571.981145965 114237728.24306737 1.0 1.6246041285957042 15.28558947995172 22.83336366922045 -6.9164577831375 0.8505850543509531 0.6584076409787203 17.318537844703684 0.9931389880898802 0.5460238164315573 0.10030120448855982 0.116746051264391 0.4618343029505795 1.3398451433237732 1.2121105097876265e-07 6.9164577831375 16.660130203724965 up QISQEHTPVALEAYFVPLVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QISQEHTPVALEAYFVPLVKR 21 1 P30154;P30154-2;P30154-4;P30154-3 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 20846700.0 1589500.0 3577200.0 15680000.0 True False 2177181.1046223724 3419147.4757814985 11976706.939736765 1.0 1.5704469731628241 5.5010154710184755 21.054029989653827 -6.932982586178825 0.7218892408645772 0.9463387825903004 6.372858176298003 0.9970926660328997 0.10789018882868823 0.09111845691492193 0.070308085053752 0.1000987679519785 0.34999887472850383 1.1668564033366927e-07 6.932982586178825 5.426519393707703 up QISQEHTPVALEAYFVPLVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QISQEHTPVALEAYFVPLVKR 21 1 P30154;P30154-2;P30154-4;P30154-3 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 157952600.0 4926300.0 19246300.0 133780000.0 True False 6377192.461890623 18175226.486142583 109433412.69871789 1.0 2.8500357476672797 17.160123887224593 22.6044899913129 -6.930729222694929 0.7407912937347779 0.7881683770353841 20.153128912722778 0.9966794862187017 0.41613112181354306 0.0922609868313476 0.07584057973415448 0.380772621697545 1.2896635463350603 1.1729264429267898e-07 6.930729222694929 19.364960535687395 QISRPSAAGINLMIGSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QISRPSAAGINLMIGSTR 18 1 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 0 41374000.0 12521000.0 14611000.0 14242000.0 False True 16415152.253536494 12431095.753231924 12768374.45891068 1.0 0.7572939660400505 0.7778407572284229 23.968524795444598 -10.700535462530144 6.712930352402983 1.002269930335638 0.7675673616342369 0.994173370730903 0.008388192377171012 0.0002873971898376498 1.282079214793245e-05 0.00819108870020242 0.002707277448463947 1.9928037761455766e-11 10.700535462530144 -0.23470256870140105 QISRPSAAGINLMIGSTR ddPTM_RPMI8226_Bortezomib_2h_R1 2 QISRPSAAGINLMIGSTR 18 1 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 0 48172600.0 19465400.0 10267500.0 18439700.0 False True 18847481.531821243 14367366.294305176 13609789.390857644 1.0 0.7622963455381536 0.7221012190875203 24.167868422490937 -13.999999999999998 0.2500576218619234 2.653598382155008 0.7059482484944128 0.9995427952193345 0.002622143417253594 14.000207142217468 0.15823460729073907 11.629038279904375 0.018543804548681077 1.0000000000000041e-14 13.999999999999998 -1.9476501336605954 QISRPSAAGINLMIGSTR ddPTM_RPMI8226_Bortezomib_8h_R1 2 QISRPSAAGINLMIGSTR 18 1 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 0 309579000.0 66887000.0 112277000.0 130415000.0 False True 101472469.09470204 92240292.12579499 104638418.08707492 1.0 0.9090179134175709 1.0312000784115953 26.596513116182475 -6.70732047983742 1.8046619177746568 0.9439141808163121 1.0308921697386757 0.4524122509912455 0.038355774544135995 0.3804861588695821 2.413822394464015 0.01692397657327649 0.04313665517139365 1.961911984707616e-07 6.70732047983742 0.08697798892236364 QISRPSAAGINLMIGSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QISRPSAAGINLMIGSTR 18 1 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 0 67387600.0 16418500.0 27939200.0 23029900.0 False True 22488863.1432793 26704753.761420783 17590711.93567879 1.0 1.187465706526894 0.7821965843095853 24.422707396069438 -6.780911197954555 1.5321507724380723 1.1060223427967424 0.7788845126595602 0.7706495998098424 0.07930907327798968 0.24916514213833563 1.1553427452640355 0.04076589281382596 0.09612421367227128 1.656108560433592e-07 6.780911197954555 -0.32713783013718223 QISRPSAAGINLMIGSTR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 QISRPSAAGINLMIGSTR 18 1 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 0 40678400.0 19465400.0 9180300.0 12032700.0 False True 16186342.563432544 9130843.901753126 14548681.937081179 1.0 0.5641079117144794 0.8988245417435379 23.948273697925213 -9.788631823242293 6.098930800431412 1.0000000109887486 0.7314662267286294 0.46184106101942457 0.13664749200054108 2.0544029689536026e-08 3.879135913308944e-09 0.1323083711188232 0.04410278840139382 1.6269274125240965e-10 9.788631823242293 -0.2685337842601192 QISRPSAAGINLMIGSTR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 QISRPSAAGINLMIGSTR 18 1 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 0 277955000.0 66887000.0 106771000.0 104297000.0 False True 86586540.03988345 100829099.99074794 85316016.17759143 1.0 1.16448930681725 0.9853265431127426 26.367639438274924 -6.665260289281377 1.9540220685374077 1.105415707490724 0.9860609844546464 0.2583141172255893 0.06994830104795734 0.4720773195030622 3.4702427467875494 0.028865039282509945 0.07760427224146195 2.1614227122119284e-07 6.665260289281377 -0.11935472303607764 QISSAMEQLQEALK(ub)VR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QISSAMEQLQEALKVR 16 1 G5E9G4;Q9ULT0;Q9ULT0-4 G5E9G4 TTC7A Tetratricopeptide repeat protein 7A 1 9765100.0 1710200.0 1507600.0 6547300.0 True False 1422107.0747060115 1499478.2595648284 7916310.158705171 1.0 1.0544060192336866 5.566606270024843 20.439598663206773 -6.909532035940224 0.8989150878828471 0.8582172618574356 6.143934240361686 0.9907437876444237 0.20588872119097082 0.10472829929237437 0.14045158341581948 0.16817480155578246 0.4627474562936173 1.231595133181312e-07 6.909532035940224 5.28571697850425 up QISVGFIGYPNVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QISVGFIGYPNVGK 14 0 Q13823;H0YG10 Q13823 GNL2 Nucleolar GTP-binding protein 2 0 9722900.0 3217800.0 3223700.0 3281400.0 False True 4218566.961219524 2742736.5258841775 2941872.205411422 1.0 0.6501583478696978 0.6973629273768767 22.008321570850352 -10.13668172080147 4.754793240549549 1.0000256233608837 0.673760637620926 0.9845406754915732 0.019271188895097272 5.234953235361855e-06 9.504828043944217e-07 0.018660712548502184 0.006219749469718402 7.299923000279572e-11 10.13668172080147 -0.32626498573995777 QISVGFIGYPNVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QISVGFIGYPNVGK 14 0 Q13823;H0YG10 Q13823 GNL2 Nucleolar GTP-binding protein 2 0 6940600.0 2571700.0 1349500.0 3019400.0 False True 2490062.7911774106 1888362.3875495307 2228528.5599416243 1.0 0.7583593450896997 0.894968820801454 21.247750692090655 -10.146288587214345 4.915805450483328 1.000011020696111 0.8266640830390726 0.6821981956349086 0.055770584922479466 6.736556776366506e-06 1.1699434662512858e-06 0.05400306904957766 0.01799987888413333 7.140217033934683e-11 10.146288587214345 -0.17334693765703846 QISVGFIGYPNVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QISVGFIGYPNVGK 14 0 Q13823;H0YG10 Q13823 GNL2 Nucleolar GTP-binding protein 2 0 9707600.0 2512700.0 4083900.0 3111000.0 False True 3811949.6029760344 3355096.137343666 2496109.486400264 1.0 0.8801522807972861 0.6548117751744466 21.862097615115268 -6.9612345877430055 0.41767220855305986 1.0102136060427107 0.516282432592705 0.9998132762075109 0.001955399487269922 0.07926304980140628 0.019523502628900152 0.002910935785135505 0.018770196679156772 1.0933656162902026e-07 6.9612345877430055 -0.4939311734500057 QISVGFIGYPNVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QISVGFIGYPNVGK 14 0 Q13823;H0YG10 Q13823 GNL2 Nucleolar GTP-binding protein 2 0 10275600.0 3217800.0 2861800.0 4196000.0 False True 4407507.617775315 2735356.2132929377 3204991.219332619 1.0 0.6206129292349597 0.7271663482570077 22.071531632373244 -10.26087805495957 8.058201521337965 1.0000003608868149 0.6738896387459848 0.9258663859998305 0.043500251158830744 2.820389361031159e-07 2.5858208393921357e-08 0.04211898351559005 0.01403964569116594 5.484309365853394e-11 10.26087805495957 -0.32611072214083003 QITGLLWNLSSNDK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QITGLLWNLSSNDKLK 16 1 Q99959-2 Q99959-2 PKP2 Plakophilin-2 1 6066300.0 2264700.0 2009300.0 1792300.0 True False 2192808.338134106 2811623.9683610764 1322842.862152537 1.0 1.282202333631005 0.603264243001814 21.064348288445927 -6.793857824022226 1.4812880687887595 1.156936463047821 0.5952975865296452 0.8134577647576279 0.12027996313479337 0.22965248165889401 0.9954122857394682 0.06390560632738383 0.14918303465298915 1.6074674071654041e-07 6.793857824022226 -0.5616388765181758 QITGLLWNLSSNDK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QITGLLWNLSSNDKLK 16 1 Q99959-2 Q99959-2 PKP2 Plakophilin-2 1 6745800.0 2264700.0 1937900.0 2543200.0 True False 1883198.393221086 1927460.148056969 3074971.3615717925 1.0 1.0235035007438469 1.6328451493165614 20.844753563880204 -6.915044420165676 0.8606882777322697 0.9840070307591239 1.7207150201179824 0.992689417153137 0.02504723221457554 0.10117685625184787 0.12137800393170718 0.02103216934667167 0.0603017860825121 1.216061614030353e-07 6.915044420165676 0.7367079893588585 QITQVYGFYDECQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QITQVYGFYDECQTK 15 0 O00743-2;O00743;O00743-3;Q5T1S7 O00743-2 PPP6C Serine/threonine-protein phosphatase 6 catalytic subunit;Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed;Serine/threonine-protein phosphatase 0 4034500.0 1780500.0 2254000.0 0.0 False True 2334252.7423865255 1917711.9860231855 0.0 1.0 0.8215528469562935 0.0 21.15452934735602 -7.218118011011756 0.8776255819942449 0.9900628982610122 7.830223584815652e-16 0.989165873081879 0.04532794810065914 0.09481532789729179 0.13947539980130527 0.03827217817056103 0.06724603287880433 6.05176407584388e-08 7.218118011011756 -0.9900628982610115 down QITSYGETCPGLEQYAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QITSYGETCPGLEQYAIK 18 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 16957600.0 1432200.0 7553200.0 7972200.0 False True 1877628.0694445278 6426292.002142994 7147313.218742288 1.0 3.422558549651492 3.8065649608959715 20.84047988390853 -9.984534829399903 0.441539560396889 3.9648834711198e-21 3.8234787474979393 0.9989948318059381 0.03939100214355152 1.2942426886194895 0.19871925929135575 1.8161741006089713 0.08777522872400816 1.0362514961564717e-10 9.984534829399903 3.8234787474979393 QITSYGETCPGLEQYAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QITSYGETCPGLEQYAIK 18 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 9314200.0 3096300.0 1103100.0 5114800.0 False True 2998009.651328933 1543573.5825905057 3775080.439289071 1.0 0.5148661152262413 1.2591955591656234 21.51557359700687 -6.730851601244976 1.7205250578226707 0.7083211946167918 1.2587896681285167 0.5630597749882129 0.2039245688404979 0.334630738485324 1.9410937767374292 0.09391945752481047 0.23279481421582257 1.8584393767584782e-07 6.730851601244976 0.5504684735117249 QITSYGETCPGLEQYAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QITSYGETCPGLEQYAIK 18 0 P50990;P50990-2;P50990-3 P50990 CCT8 T-complex protein 1 subunit theta 0 17091400.0 1432200.0 7600300.0 8058900.0 False True 1961723.0437497066 7264493.615168879 6155553.798255401 1.0 3.703118867015636 3.137830193649282 20.90368994543142 -10.71559021415932 9.486013194816042 0.9951472766209513 3.4204745303324593 0.9607003445179575 0.23077813452039908 0.02346818582710099 0.000703621900374255 0.2214082530225688 0.07448332263886008 1.9249071507086545e-11 10.71559021415932 2.425327253711508 QITVNDLPVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QITVNDLPVGR 11 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5;P32119 Q06830;P32119 PRDX1;PRDX2 Peroxiredoxin-1;Peroxiredoxin-2 0 126143000.0 9501000.0 71899000.0 44743000.0 False True 12455903.007814895 61171949.46010692 40113423.565162204 1.0 4.911081069090481 3.220434804284751 23.570326279742307 -9.377897398570678 10.536288413840051 1.0000000000004896 4.06575793668311 0.8142778645292976 0.6902034473860584 0.0 0.0 0.6682866143052862 0.2227622047684287 4.188925161666247e-10 9.377897398570678 3.065757936682621 QITVNDLPVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QITVNDLPVGR 11 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5;P32119 Q06830;P32119 PRDX1;PRDX2 Peroxiredoxin-1;Peroxiredoxin-2 0 119722000.0 49420000.0 18894000.0 51408000.0 False True 47851189.1511403 26438472.73090836 37942702.59305792 1.0 0.5525144348534613 0.7929312367392596 25.512051441820137 -10.168041470887623 5.132714040056211 1.0000175675160707 0.672722835796075 0.7118833648909053 0.09814974836966163 1.9732082921775498e-05 3.198271888295381e-06 0.09503818201619911 0.03167769507236935 6.791387783906347e-11 10.168041470887623 -0.3272947317199958 QITVNDLPVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QITVNDLPVGR 11 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5;P32119 Q06830;P32119 PRDX1;PRDX2 Peroxiredoxin-1;Peroxiredoxin-2 0 486495700.0 14736000.0 462880000.0 8879700.0 False True 22355589.345904723 380275447.502053 7124623.402889229 1.0 17.010307427735736 0.31869539615578846 24.41413224342722 -6.574282002292689 2.289033860009186 9.999999999999998 0.3556301601949071 0.2690501377914124 6.59421887796147 0.5209047016982964 5.127584781731236 2.576358593082584 7.8373340320088225 2.6651275438819383e-07 6.574282002292689 -9.64436983980509 QITVNDLPVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QITVNDLPVGR 11 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5;P32119 Q06830;P32119 PRDX1;PRDX2 Peroxiredoxin-1;Peroxiredoxin-2 0 151673000.0 9501000.0 73303000.0 68869000.0 False True 13013776.454870826 70064231.07939476 52603560.60157719 1.0 5.383850823192138 4.042144168066496 23.6335363412652 -9.828944893311855 6.396805753353723 0.9999998963267005 4.712997495630161 0.9108027561830688 0.5477494482620601 9.375174815387673e-07 1.7049185972806024e-07 0.5303561385561092 0.17678537425065896 1.4827062105966977e-10 9.828944893311855 3.71299759930346 QITVNDLPVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QITVNDLPVGR 11 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5;P32119 Q06830;P32119 PRDX1;PRDX2 Peroxiredoxin-1;Peroxiredoxin-2 0 57638000.0 49420000.0 4839000.0 3379000.0 False True 41094919.677213766 4812931.346533703 4085533.2772692153 1.0 0.11711742921844347 0.09941699142764243 25.292456717254414 QITVNDLPVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QITVNDLPVGR 11 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5;P32119 Q06830;P32119 PRDX1;PRDX2 Peroxiredoxin-1;Peroxiredoxin-2 0 44484000.0 14736000.0 14831000.0 14917000.0 False True 19076042.489986435 14005641.812503207 12202259.061345309 1.0 0.7342005984655975 0.6396640743356818 24.185258565519668 -13.999999999999998 0.14399015623850714 2.274861934686125 0.5281092407720088 0.9995875153172629 0.003098130801659295 11.94018168460386 0.11916365188852118 4.268406181045484 0.10001988185473468 1.0000000000000041e-14 13.999999999999998 -1.7467526939141163 QIVLAK(ub)VDQALHTQTDADPAEEYAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QIVLAKVDQALHTQTDADPAEEYAR 25 1 P52888;K7EP46;K7EL02;K7EIK4;K7EL32;P52888-2 P52888 THOP1 Thimet oligopeptidase 1 19531500.0 5989900.0 4009200.0 9532400.0 True False 5799753.903205489 5610094.4677018 7035578.474129806 1.0 0.967298709795451 1.213082243065742 22.46756025401998 -6.873378465179749 1.1161345801549498 0.9810700597892421 1.2284275965060008 0.9679370620150649 0.019513475370270632 0.13365347694973564 0.3091496565377583 0.01353904926842816 0.03225447197018665 1.3385097370217515e-07 6.873378465179749 0.24735753671675864 QIVLAK(ub)VDQALHTQTDADPAEEYAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QIVLAKVDQALHTQTDADPAEEYAR 25 1 P52888;K7EP46;K7EL02;K7EIK4;K7EL32;P52888-2 P52888 THOP1 Thimet oligopeptidase 1 19318300.0 5989900.0 5045200.0 8283200.0 True False 4980867.24756258 5018020.506206208 10015178.82281043 1.0 1.0074591947138942 2.0107299241334777 22.247965529454255 -6.908528969952386 0.9056825884275057 0.9674727173270241 2.1363923188106115 0.9903547016959589 0.04662191614944023 0.10539935557886158 0.14409919078140873 0.037894440076340574 0.10357123974548879 1.234442967942531e-07 6.908528969952386 1.1689196014835874 up QIVSEDK(ub)ELFNLESR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QIVSEDKELFNLESR 15 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 15914800.0 4784000.0 4397600.0 6733200.0 True False 6271870.3283219 3741495.221710543 6036513.053415071 1.0 0.5965517502514464 0.9624741484459547 22.580464301191064 -10.364479176785943 8.379561246023211 1.000001042311254 0.7795129493487005 0.32618682909587204 0.149387193505345 2.908917216587464e-06 2.2069333995033032e-07 0.14464421133759375 0.04821450938190553 4.3203688208995434e-11 10.364479176785943 -0.22048809296255345 QIVSEDK(ub)ELFNLESR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QIVSEDKELFNLESR 15 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 13106100.0 4784000.0 3570200.0 4751900.0 True False 6552774.082738864 3412456.7589274044 3629599.0884524924 1.0 0.5207652081148965 0.5539026742907988 22.643674362713956 -10.03314730774396 5.213254689946726 1.000004215199992 0.5373339412014866 0.9961673693544254 0.013528313921368263 6.627857453434688e-07 1.2293779369198082e-07 0.013098852950281131 0.004366244542626249 9.265155065642722e-11 10.03314730774396 -0.46267027399850535 QIVSEDK(ub)ELFNLESR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIVSEDKELFNLESR 15 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 27511100.0 18660000.0 5727800.0 3123300.0 True False 24155737.843590356 5409042.894859139 2554891.4477642826 1.0 0.22392372900728472 0.10576747704033451 24.525862585167456 -13.999999999999998 0.265001511995786 6.832511154107631 0.0646071452418842 0.9995726983758914 0.008199045313328645 14.644103006066917 0.16292404211561592 45.876936507296286 0.05033051091308027 1.0000000000000041e-14 13.999999999999998 -6.767904008865747 QIYYSDK(ub)YDDEEFEYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QIYYSDKYDDEEFEYR 16 1 P61024;Q5T179 P61024 CKS1B Cyclin-dependent kinases regulatory subunit 1;Cyclin-dependent kinases regulatory subunit 1 34124900.0 2139900.0 11091000.0 20894000.0 True False 3246384.7476453246 9111724.395621471 16764291.741834495 1.0 2.806729671284468 5.163987957371353 21.630402561393094 -6.967471336004294 0.31274491554066636 0.6484176714142216 7.397529428958467 0.999955402511253 0.011385459354385069 0.0771320389445771 0.011952775582891687 0.036843154125296915 0.20873047672214207 1.0777763859778475e-07 6.967471336004294 6.749111757544246 QIYYSDK(ub)YDDEEFEYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QIYYSDKYDDEEFEYR 16 1 P61024;Q5T179 P61024 CKS1B Cyclin-dependent kinases regulatory subunit 1;Cyclin-dependent kinases regulatory subunit 1 40658400.0 2139900.0 7056500.0 31462000.0 True False 2770142.733735203 6663799.5718379645 25736238.827381223 1.0 2.4055798608083405 9.290582219450842 21.401528883485543 -6.940264616072503 0.6570977098365808 0.923055440211944 11.16178741100752 0.9981983471202959 0.15376678737568394 0.08764613864557955 0.05406159267118673 0.1499821276021837 0.591890947294597 1.147454263401134e-07 6.940264616072503 10.238731970795577 QK(ub)APAPEAEDEEVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QKAPAPEAEDEEVAR 15 1 Q8NBN7;Q8NBN7-2 Q8NBN7 RDH13 Retinol dehydrogenase 13 1 3670930.0 399630.0 762000.0 2509300.0 True False 332310.05161078373 757894.954754843 3033983.028307683 1.0 2.2806862178292553 9.1299766997756 18.342170406316324 -6.938315578903325 0.6750527472977077 0.9204182012511517 10.888942267850668 0.9979348336931931 0.16219679348493987 0.08854360374913171 0.058172684449749254 0.15593963030537566 0.5940130363102112 1.1526154085977627e-07 6.938315578903325 9.968524066599516 QK(ub)DTEPTNFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QKDTEPTNFK 10 1 E9PHA2;Q15003;Q15003-2;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 1 5050300.0 1628300.0 1431100.0 1990900.0 True False 1576610.507786358 2002545.6930879075 1469423.5642802478 1.0 1.2701587888689037 0.9320143161695617 20.588394864272715 -6.693939104258596 1.8526729779003726 1.168743961314794 0.9331318923751141 0.38885084921273905 0.11416838402429037 0.40823265484230137 2.71973197885136 0.0492457831463405 0.12759438596992284 2.0233028615138373e-07 6.693939104258596 -0.23561206893968 QK(ub)EDNHIFGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QKEDNHIFGR 10 1 Q96PZ2;E9PR18 Q96PZ2 FAM111A Protein FAM111A 1 12090000.0 2471900.0 4914200.0 4703900.0 True False 3750053.0200964906 4037222.6151801543 3774172.1032073908 1.0 1.0765774759835995 1.0064316645609133 21.8384795626099 -6.62531139466741 2.0970360518864846 1.0506223942550086 1.006706431405158 0.10086323577836886 0.03288696897203065 0.571457077455122 4.782360973864698 0.012852693424288365 0.03645318115133628 2.3696740099772133e-07 6.62531139466741 -0.043915962849850665 QK(ub)ELLLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QKELLLQK 8 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9;Q5T4C6 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 10382400.0 4118600.0 4139600.0 2124200.0 True False 5399524.484579134 3521987.816034417 1904408.1607652053 1.0 0.6522774044442431 0.35269923605386605 22.36440092957317 -7.483612621619216 0.23410862669587318 1.149850727773641 2.2579187290016984e-11 0.9999068951627688 0.002552204995936606 0.12602926976833512 0.02188703845271623 0.02718278683495566 0.06381687243987047 3.283880753818738e-08 7.483612621619216 -1.1498507277510617 down QK(ub)ELLLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QKELLLQK 8 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9;Q5T4C6 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 14770300.0 5561000.0 5352200.0 3857100.0 True False 5384469.098937496 7489361.3713542735 2846809.799480308 1.0 1.3909191851118863 0.5287076120544665 22.360372673408687 -6.783438014264729 1.5224478777300312 1.2203598239701525 0.5211227765975699 0.7793768409773004 0.16557388145439095 0.24526813962930585 1.1230570718520254 0.08563905185557502 0.20150175936047554 1.6465009504077268e-07 6.783438014264729 -0.6992370473725826 QK(ub)ELLLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QKELLLQK 8 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9;Q5T4C6 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 11396200.0 4118600.0 3991100.0 3286500.0 True False 5641357.720979992 3814760.005197234 2510296.387592149 1.0 0.6762131022130166 0.44498089143619685 22.42761099109606 -7.848519490161141 0.15710741485196641 1.3195582237883994 8.759299791889281e-13 0.9999550108091494 0.0015268166483978851 0.12404105444773424 0.02277146813271382 0.07236866206952838 0.09915555455547868 1.4173611020319169e-08 7.848519490161141 -1.3195582237875234 down QK(ub)ELLLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QKELLLQK 8 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9;Q5T4C6 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 17180900.0 5561000.0 9907000.0 1712900.0 True False 4624217.894070935 9853629.024614464 2071059.4704452332 1.0 2.130874723106919 0.4478723792623824 22.140777948842963 -6.725637998933287 1.7388330777301906 1.683824825633082 0.44958811225950257 0.5390703710818435 0.4755775888057658 0.34447428707331146 2.038296260334274 0.2169113239673801 0.540991233958622 1.880883952315443e-07 6.725637998933287 -1.2342367133735794 QK(ub)ELLLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKELLLQK 8 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9;Q5T4C6 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 8409000.0 4871200.0 2246900.0 1290900.0 True False 6305864.425707242 2121858.0398161607 1055969.4457525397 1.0 0.3364896383065167 0.16745831728440722 22.588262722145547 -13.999999999999595 0.19201137304108515 4.5818792909718296 0.04861743582682609 0.9994884275711013 0.008126895171824522 12.384164642040005 0.13896045312053285 16.607870791677104 0.11441257563656315 1.0000000000009326e-14 13.999999999999595 -4.533261855145003 QK(ub)ENADPRPPVQFPNLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QKENADPRPPVQFPNLPR 18 2 Q5TDH0;Q5TDH0-3;Q5TDH0-2 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 76796100.0 23695800.0 25923300.0 27177000.0 True False 31065423.270453647 22055644.68823198 24364984.740192074 1.0 0.7099740601058903 0.784312015583114 24.888806375533587 -10.288087665742932 12.070361416957445 1.0000000006454102 0.7471430378445024 0.9391227490017162 0.030348343240155368 5.107252509844078e-10 3.627609151574221e-11 0.02938465698852705 0.009794885662842348 5.15124652140341e-11 10.288087665742932 -0.25285696280090775 QK(ub)ENADPRPPVQFPNLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QKENADPRPPVQFPNLPR 18 2 Q5TDH0;Q5TDH0-3;Q5TDH0-2 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 105734400.0 33011400.0 37361000.0 35362000.0 True False 31963471.17652675 52279442.135041095 26099631.362739522 1.0 1.6355996458054884 0.8165455878867905 24.929920755119152 -6.699569206844537 1.8323432376131754 1.3948583361180507 0.8190032740754345 0.41546758544217677 0.2683177001591654 0.3964718665135666 2.5876275779247138 0.11683334117095774 0.3006313923559494 1.9972424732100515e-07 6.699569206844537 -0.5758550620426162 QK(ub)ENADPRPPVQFPNLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QKENADPRPPVQFPNLPR 18 2 Q5TDH0;Q5TDH0-3;Q5TDH0-2 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 106639600.0 35142000.0 29452000.0 42045600.0 True False 53312983.224333845 24196060.490473673 33735268.73075888 1.0 0.45384930700013376 0.6327777342491869 25.667983577166556 -10.257664687451882 6.831254089527028 1.000003877367935 0.5433135206246614 0.896757467546096 0.07304722453981373 4.31367064359252e-06 4.687870895750053e-07 0.07072827097916025 0.023575890344114364 5.525038549565353e-11 10.257664687451882 -0.4566903567432735 QK(ub)ENADPRPPVQFPNLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QKENADPRPPVQFPNLPR 18 2 Q5TDH0;Q5TDH0-3;Q5TDH0-2 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 85035900.0 23695800.0 26283100.0 35057000.0 True False 32456777.614917174 25121825.735411145 26777258.62157853 1.0 0.7740086225893579 0.8250128506063298 24.95201643705648 -10.77477847538204 6.993104522820013 1.0053344967719886 0.7995107365978602 0.9537079090464464 0.02082238889435785 0.0017649018578101325 5.684075719162278e-05 0.02054664265614391 0.006720397118008513 1.6796605597059827e-11 10.77477847538204 -0.2058237601741284 QK(ub)ENADPRPPVQFPNLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QKENADPRPPVQFPNLPR 18 2 Q5TDH0;Q5TDH0-3;Q5TDH0-2 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 86285400.0 33011400.0 33086500.0 20187500.0 True False 27450441.75298207 32908256.457343973 24408612.91354612 1.0 1.1988242941033542 0.8891883465188497 24.71032603055343 -6.73327532376438 1.7112332238682793 1.1192085297149983 0.8892561739654984 0.5744844780972722 0.08356112208281034 0.33009277998427133 1.8951178969626812 0.03867337872156289 0.0956135768146617 1.8480966348425516e-07 6.73327532376438 -0.2299523557494999 QK(ub)ENADPRPPVQFPNLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKENADPRPPVQFPNLPR 18 2 Q5TDH0;Q5TDH0-3;Q5TDH0-2 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 87817000.0 35142000.0 33924000.0 18751000.0 True False 45492011.75238213 32036099.578407336 15338510.401507402 1.0 0.7042137365299043 0.33716931414237183 25.439109899259005 -7.050236672215755 0.31019097296399967 1.059477818438331 2.4290826598741167e-14 0.9999580879412427 0.001755209986111547 0.07293130728561945 0.011999831050644557 0.0061709560457020324 0.031394774481178375 8.907653761973627e-08 7.050236672215755 -1.059477818438307 down QK(ub)EVEQLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QKEVEQLIK 9 1 P25789;H0YN18;P25789-2 P25789 PSMA4 Proteasome subunit alpha type-4 1 8011900.0 2689100.0 3523500.0 1799300.0 True False 3525436.141281444 2997807.5344954273 1613125.6961043389 1.0 0.8503366432857208 0.4575676970049985 21.74937031759903 -6.954413151557099 0.5080907370741191 1.007343599308342 0.2833853532724108 0.999503645212891 0.005096108058750992 0.08176055855487457 0.028991886662327007 0.00588925023252667 0.03241223123335166 1.1106746213172702e-07 6.954413151557099 -0.7239582460359311 down QK(ub)EVEQLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QKEVEQLIK 9 1 P25789;H0YN18;P25789-2 P25789 PSMA4 Proteasome subunit alpha type-4 1 10100300.0 2942700.0 3257600.0 3900000.0 True False 2849285.599252545 4558376.668159576 2878473.002507896 1.0 1.5998314347131009 1.0102437618970201 21.44216880733361 -10.43049713840108 5.497655230245535 0.9997743564170934 1.3050375983050622 0.2630269725256086 0.24069815950573778 0.0006661813922408649 6.900979664231287e-05 0.23322547325247475 0.07768499693570745 3.711101747576504e-11 10.43049713840108 0.3052632418879687 QK(ub)EVEQLIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QKEVEQLIK 9 1 P25789;H0YN18;P25789-2 P25789 PSMA4 Proteasome subunit alpha type-4 1 19929100.0 8510600.0 4632800.0 6785700.0 True False 12911202.40820148 3806040.6437683916 5444503.420722038 1.0 0.29478591717768365 0.421688333014094 23.622120027952768 -10.45709204870792 5.885604741773736 1.0004092917376595 0.3582371251080777 0.9715095733674638 0.05180769432094968 0.000278409161503246 2.5681412129307725e-05 0.050193020055004714 0.01672086144253675 3.4906632303639036e-11 10.45709204870792 -0.6421721666295818 QK(ub)EVEQLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QKEVEQLIK 9 1 P25789;H0YN18;P25789-2 P25789 PSMA4 Proteasome subunit alpha type-4 1 6961800.0 2689100.0 1925400.0 2347300.0 True False 3683332.940195043 1840329.4615536456 1792916.084160975 1.0 0.49963701121631293 0.4867645996905278 21.812580379121922 QK(ub)EVEQLIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKEVEQLIK 9 1 P25789;H0YN18;P25789-2 P25789 PSMA4 Proteasome subunit alpha type-4 1 24076700.0 8510600.0 11735000.0 3831100.0 True False 11017139.469006432 11081936.93410596 3133879.1104055755 1.0 1.0058815144604294 0.28445488225159055 23.393246350045217 -6.90506270564258 0.9287168737690631 1.0259719673648746 0.20043921909621143 0.9889208150792043 0.035651416565924764 0.10777379818253374 0.15715289286421547 0.028493705551181095 0.07620710091619391 1.2443349354038828e-07 6.90506270564258 -0.8255327482686632 down QK(ub)GADFLVTEVENGGSLGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QKGADFLVTEVENGGSLGSK 20 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 97628000.0 2950400.0 9317600.0 85360000.0 True False 4475972.503132288 7654801.481258922 68488558.58538291 1.0 1.7101985045489192 15.301380546340393 22.09376974287786 -6.917723687432427 0.8414405613782564 0.6748176779294496 17.38227202613223 0.993524822751673 0.529541401104819 0.09952965129909457 0.11269238197620085 0.4508379818865372 1.3224288459754956 1.2085825308759618e-07 6.917723687432427 16.70745434820278 up QK(ub)GADFLVTEVENGGSLGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKGADFLVTEVENGGSLGSK 20 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BQ34 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 73582900.0 2950400.0 4351500.0 66281000.0 True False 3819350.9610787225 4109335.1997240805 54218538.10049123 1.0 1.0759250044315005 14.195746516360456 21.86489606497031 -6.9081704025141555 0.908112336929195 0.5699071037020326 15.826501484301598 0.9902124151012169 0.6136485184572021 0.10564012710101871 0.14542527676379363 0.4979009494453412 1.3576036647574017 1.2354625844621886e-07 6.9081704025141555 15.256594380599566 up QK(ub)GSPDEYHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QKGSPDEYHLR 11 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 31933000.0 10366000.0 10990000.0 10577000.0 True False 13589926.384486793 9350334.838684473 9482593.501748223 1.0 0.688034252294265 0.6977663626326054 23.69603430537766 -10.011686669243073 5.425597438392743 1.0000013337950633 0.6929003074630007 0.9992473544938612 0.003973117409759339 6.41028256529074e-08 1.1674966432101231e-08 0.003846971127052707 0.001282318129822785 9.73449285654779e-11 10.011686669243073 -0.3071010263320626 QK(ub)GSPDEYHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QKGSPDEYHLR 11 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 41775700.0 9778700.0 12601000.0 19396000.0 True False 9468280.521089753 17632645.013346903 14315605.732472593 1.0 1.8622858684923576 1.5119541188694035 23.17467101941759 -10.137419641775404 4.929219060672577 0.9999615257076616 1.687119993683237 0.8368450858852605 0.14302233788695415 6.047771630136962e-05 1.0582921516066049e-05 0.1384885090898295 0.046160261063152457 7.28753004409832e-11 10.137419641775404 0.6871584679755754 QK(ub)GSPDEYHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QKGSPDEYHLR 11 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 81388000.0 21703000.0 23344000.0 36341000.0 True False 32925037.701830268 19178080.812495496 29158185.421173863 1.0 0.5824771101607397 0.8855930761638274 24.97268175669674 -10.336843286983587 5.508951152323728 1.0000590912992158 0.734035093162289 0.5065446000370722 0.12374657493307754 8.983111413751071e-05 1.0813632269164159e-05 0.11984365927727753 0.039939035322165986 4.604226848585947e-11 10.336843286983587 -0.2660239981369268 QK(ub)GSPDEYHLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QKGSPDEYHLR 11 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 37806700.0 9778700.0 16157000.0 11871000.0 True False 8131422.3198618 16069959.034086589 14353171.214697523 1.0 1.9762789831779035 1.7651489063159944 22.955076294851867 -10.287640533897054 6.16004436338438 0.999964384397972 1.8707139447469296 0.9577652849134636 0.08619349294438135 4.2168441286206734e-05 4.876238150763808e-06 0.08345988291619423 0.027818830227085853 5.156552765331143e-11 10.287640533897054 0.8707495603489577 QK(ub)GSPDEYHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKGSPDEYHLR 11 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 72144000.0 21703000.0 28112000.0 22329000.0 True False 28094961.330087952 26547542.48756597 18265351.114887662 1.0 0.9449218376084827 0.6501290711984932 24.74380807878919 -6.938298791264509 0.6752063642142058 1.0034265668963864 0.5744599759478137 0.9979324465536744 0.006984399279639257 0.08855147583317807 0.05820908499474341 0.006714143730658755 0.025568261468250607 1.152659963769346e-07 6.938298791264509 -0.4289665909485727 QK(ub)IEQELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKIEQELR 8 1 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;J3QRY6 Q5TA45-4 CPSF3L Integrator complex subunit 11 1 10083900.0 1077800.0 1459500.0 7546600.0 True False 1395233.3466142355 1378277.5419963882 6173196.234654982 1.0 0.9878473341688734 4.424490175521724 20.412074995930716 -6.906101355783426 0.9218583477765244 0.8800355277895953 4.833509659590784 0.9893657241814721 0.16676910197717632 0.1070533857824222 0.1531626734631503 0.13395703886133578 0.36052447351889494 1.2413625641960132e-07 6.906101355783426 3.9534741318011886 up QK(ub)IVQAEGEAEAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QKIVQAEGEAEAAK 14 1 Q99623;J3KPX7;F5GY37 Q99623 PHB2 Prohibitin-2 1 18032330.0 788430.0 1551900.0 15692000.0 True False 1196105.9519538323 1274951.3199499568 12590469.321952078 1.0 1.0659183811160968 10.526215759887842 20.18991375951914 -6.908425510485678 0.9063632982031818 0.6923068327967639 11.708611917290133 0.9903144008569436 0.4404332105835738 0.10546902160389662 0.1444725924092989 0.3578049657836814 0.9772868039655622 1.2347370771934123e-07 6.908425510485678 11.01630508449337 up QK(ub)IVQAEGEAEAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKIVQAEGEAEAAK 14 1 Q99623;J3KPX7;F5GY37 Q99623 PHB2 Prohibitin-2 1 12444130.0 788430.0 1585700.0 10070000.0 True False 1020638.1772787739 1497454.401057674 8237363.326925457 1.0 1.467174591734544 8.070796791952189 19.96104008161159 -6.921166823852991 0.816025184624116 0.8603323935777002 9.164808212930492 0.994498951019817 0.23947181876021426 0.09749016815382475 0.1020920935371901 0.2076143466255391 0.6290140721892058 1.199038632623108e-07 6.921166823852991 8.304475819352792 up QK(ub)MPLDDLDREDEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QKMPLDDLDREDEVR 15 2 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 7139700.0 1216900.0 2307100.0 3615700.0 True False 1011906.2678106315 2294671.194376504 4371726.15289207 1.0 2.267671687953147 4.320287651099119 19.948644229684884 -6.9639552570469165 0.37555077744455995 0.851758472860133 5.808277032431709 0.9998899637893097 0.014350797034633043 0.07831729668840029 0.016121035416084756 0.026848246075507225 0.17382418592977597 1.0865375577926574e-07 6.9639552570469165 4.956518559571577 QK(ub)MPLDDLDREDEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKMPLDDLDREDEVR 15 2 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 43747800.0 3209000.0 4466800.0 36072000.0 True False 4154113.7588468017 4218218.653367231 29507266.129975732 1.0 1.015431665631185 7.103143496524531 21.98610929371014 -6.907452714310722 0.9128890140970394 0.7959930273127557 7.848518757285742 0.9899246986326204 0.28842173916895264 0.10612717385506253 0.1480758443910511 0.23320011494636173 0.6329377463705571 1.2375059214077167e-07 6.907452714310722 7.052525729972986 up QK(ub)NTNEEDDEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QKNTNEEDDEVR 12 1 F8W7U8;P49959-2;P49959;P49959-3 F8W7U8 MRE11A Double-strand break repair protein MRE11A 1 3063200.0 1096600.0 1216800.0 749800.0 True False 1437653.2194895062 1035258.1830492506 672217.8885894697 1.0 0.7201028516576888 0.467579997371109 20.455284290402396 -6.972347944968376 0.19407367339750708 1.1622971972459752 0.018457559017692915 0.9999953727286627 0.0004677344913587058 0.07554788569450364 0.0062213934717292385 0.008612844825067224 0.02722445539394967 1.0657419355463945e-07 6.972347944968376 -1.1438396382282823 down QK(ub)NTNEEDDEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QKNTNEEDDEVR 12 1 F8W7U8;P49959-2;P49959;P49959-3 F8W7U8 MRE11A Double-strand break repair protein MRE11A 1 3104680.0 1096600.0 1345700.0 662380.0 True False 1502042.6545007192 1286242.5243651906 505939.486144313 1.0 0.8563288935311489 0.3368343000302398 20.518494351925288 -6.947196518790312 0.5888203813894507 1.0060259799440754 0.16104998499793965 0.9989624931149192 0.009175425647637146 0.08463145142124713 0.04077503487883052 0.009524101101150767 0.04350539687230581 1.129284796273352e-07 6.947196518790312 -0.8449759949461357 down QK(ub)NVSEELDRTPPEVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKNVSEELDRTPPEVSK 17 2 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 1 27936500.0 1724500.0 5287100.0 20924900.0 True False 2232399.244977038 4992868.237265574 17116782.907605045 1.0 2.2365480764695964 7.667438047257136 21.090163632889187 -6.9427332169844975 0.6336250849809687 0.9407272203723966 9.257778890831123 0.9985004408589953 0.11214288757033622 0.08654153362920956 0.04909526437300221 0.11157233064759248 0.4620920736507968 1.1409504474634775e-07 6.9427332169844975 8.317051670458726 QK(ub)PCDLPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKPCDLPLR 9 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 9575500.0 3125400.0 3811300.0 2638800.0 True False 4045891.910844434 3599197.804598041 2158565.4763744725 1.0 0.8895931685547275 0.5335203025539923 21.948026347012828 -6.9498137210116075 0.5608848145867761 1.0046355649379817 0.4014347446030556 0.9991865842328963 0.0056769337969768555 0.08356062665436836 0.03627257262625509 0.006078866141905575 0.029605027788156064 1.1224998172988173e-07 6.9498137210116075 -0.6032008203349261 QK(ub)PVQTFTEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QKPVQTFTEEK 11 1 Q9NYL9 Q9NYL9 TMOD3 Tropomodulin-3 1 6061900.0 1988600.0 3002900.0 1070400.0 True False 2607073.857629792 2554879.025212523 959645.2760018244 1.0 0.9799795344253417 0.36809286134850094 21.31400002389956 -6.913861840488076 0.8690261006307927 1.016710745997878 0.2821204948905726 0.9922990053634466 0.02573678269313615 0.1019194933996729 0.12532624905023076 0.02148191710221124 0.061012958632024515 1.21937745050097e-07 6.913861840488076 -0.7345902511073052 down QK(ub)PVQTFTEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QKPVQTFTEEK 11 1 Q9NYL9 Q9NYL9 TMOD3 Tropomodulin-3 1 7963500.0 2661400.0 3578500.0 1723600.0 True False 2576915.313776704 5007413.711630968 1272137.453108362 1.0 1.9431813241437677 0.4936667675135698 21.297213695422784 -6.731065908809365 1.7191273380864553 1.5669081906846334 0.4943207867635004 0.5643418752737188 0.3964574626546715 0.3342205793291703 1.9355442632283335 0.18270991485003776 0.4528736003109868 1.857522534887731e-07 6.731065908809365 -1.072587403921133 QK(ub)PVQTFTEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QKPVQTFTEEK 11 1 Q9NYL9 Q9NYL9 TMOD3 Tropomodulin-3 1 19426000.0 4574100.0 9483500.0 5368400.0 True False 6939244.111502642 7791095.330076308 4307333.386946694 1.0 1.1227585029270868 0.6207208332398574 22.72634708861486 -6.842059779888562 1.2728030342634364 1.0652965760644246 0.6035242634436825 0.9279382155878262 0.05736318049486109 0.16640532295561364 0.5227725797579676 0.035327055797569736 0.08143681904116183 1.4386005437357721e-07 6.842059779888562 -0.46177231262074214 QK(ub)PVQTFTEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QKPVQTFTEEK 11 1 Q9NYL9 Q9NYL9 TMOD3 Tropomodulin-3 1 5191900.0 1988600.0 2073300.0 1130000.0 True False 2723839.1598943346 1981694.7505137485 863117.27308052 1.0 0.7275373596547544 0.31687527141433813 21.37721008542245 -6.980603613416582 0.35788013624678044 1.036635668230624 6.903879187768654e-11 0.9999174152293496 0.0025516179080638675 0.07589823278029247 0.014652775686350403 0.00550114551693609 0.034265277455003885 1.0456741851044713e-07 6.980603613416582 -1.0366356681615851 down QK(ub)PVQTFTEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKPVQTFTEEK 11 1 Q9NYL9 Q9NYL9 TMOD3 Tropomodulin-3 1 18084700.0 4574100.0 8612600.0 4898000.0 True False 5921262.618990706 8133301.238916135 4006614.2577240267 1.0 1.3735754960151516 0.6766486331604329 22.49747341070731 -6.761110392818449 1.608348245196748 1.21669707696138 0.6739681562537349 0.6954427233110394 0.1571526302183625 0.2810664972936954 1.4332168476129403 0.07708591356361234 0.18504276559235153 1.7333633401032242e-07 6.761110392818449 -0.5427289207076452 QK(ub)SILYDER ddPTM_RPMI8226_Bortezomib_2h_R1 1 QKSILYDER 9 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 29229300.0 4675900.0 4663400.0 19890000.0 True False 4527466.113958259 6525519.93930973 14680212.312790254 1.0 1.441318339013391 3.242478672017201 22.110272412618375 -6.94441233665404 0.6171496972376718 0.9802422888289537 3.7985116616465917 0.9986865916136138 0.035152814898800476 0.0858100896460845 0.045867322159929294 0.035494210884779616 0.1522706880502242 1.136547689295529e-07 6.94441233665404 2.818269372817638 up QK(ub)SILYDER ddPTM_RPMI8226_Bortezomib_8h_R1 1 QKSILYDER 9 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 87165400.0 5447400.0 10603000.0 71115000.0 True False 8264104.058284564 8710811.80838288 57059089.07918819 1.0 1.0540539841884617 6.904449493467817 22.97842698947898 -6.908923230049962 0.9030441470190453 0.8126341367750031 7.643336864516131 0.9905086591734233 0.26993438733334163 0.10513415137884667 0.1426644531322377 0.21982902014575997 0.602388476659453 1.2333228276263667e-07 6.908923230049962 6.830702727741128 up QK(ub)SILYDER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QKSILYDER 9 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 23760400.0 4675900.0 8893500.0 10191000.0 True False 3888218.0274925954 8845588.950278472 12321890.982139861 1.0 2.27497246495273 3.169032933599639 21.89067768805265 -8.003841012340244 0.18191160261002662 1.1475183227642558e-23 4.522463357270491 0.9998859786732966 0.009503955125868158 0.10669925521518128 0.03227489038528621 0.3029840213968384 0.38538079488909444 9.911947376445089e-09 8.003841012340244 4.522463357270491 QK(ub)SILYDER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKSILYDER 9 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 44296400.0 5447400.0 10199000.0 28650000.0 True False 7051766.684307278 9631416.684358459 23435993.973824676 1.0 1.3658161302743936 3.323421636450084 22.74955331157143 -6.938302198193917 0.6751718186621471 0.9772476310416145 3.825966072243616 0.9979329857063401 0.04637552192477434 0.08854976025680782 0.05820091300885661 0.04458229710901601 0.16978613497689973 1.1526509214814785e-07 6.938302198193917 2.848718441202002 up QK(ub)TNVFAPDYIAGVSPFVENDISSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QKTNVFAPDYIAGVSPFVENDISSR 25 1 Q9ULX3 Q9ULX3 NOB1 RNA-binding protein NOB1 1 17062800.0 6745200.0 6013500.0 4304100.0 True False 5608932.663025948 5981104.081913707 5204067.410090104 1.0 1.06635334051006 0.927817772603206 22.41929483244698 -6.776467480446923 1.5496737300703474 1.0377434274708934 0.926840275434724 0.7546767417286431 0.028020967127480253 0.25610281427760273 1.2145328411773797 0.014245492957488523 0.03371344334035416 1.673140914890608e-07 6.776467480446923 -0.1109031520361694 QK(ub)VDSLLENLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QKVDSLLENLEK 12 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 17778200.0 5361100.0 5945700.0 6471400.0 True False 7028454.016966244 5058624.73615708 5801801.6060521435 1.0 0.7197350546714654 0.8254733675495295 22.74477595743618 -10.540951012201447 6.8812188837685655 1.0001577487237714 0.7726042111104974 0.860461892001835 0.043167485469002745 0.00010454136596970281 6.974013980811222e-06 0.04182547207753715 0.01393224602659153 2.8777229994816634e-11 10.540951012201447 -0.22755353761327402 QK(ub)VDSLLENLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QKVDSLLENLEK 12 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 18886100.0 6686400.0 5576300.0 6623400.0 True False 6474143.891950313 7802945.67002035 4888532.842259178 1.0 1.2052474891270513 0.7550856026442941 22.626258000039037 -6.78270721221437 1.525029403718438 1.1158050339286751 0.7511926061197488 0.7769671811200284 0.08690380210286165 0.24637912244724802 1.1318999343734306 0.044872368753792094 0.1056559615180526 1.6492739058037392e-07 6.78270721221437 -0.36461242780892633 QK(ub)VDSLLENLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QKVDSLLENLEK 12 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 15669200.0 5361100.0 5354700.0 4953400.0 True False 7343243.548279953 5118111.648375032 3783508.9384752573 1.0 0.69698241856269 0.5152367497550164 22.80798601895907 -9.878747871151816 0.0993961095011576 1.7732831499113135 0.00010698764828388866 0.9999369854810513 0.0015872848012318734 1.4367225411581852 0.04473237516392624 0.5461598359452831 0.26399102478936665 1.3220629325979445e-10 9.878747871151816 -1.7731761622630295 QK(ub)VDSLLENLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QKVDSLLENLEK 12 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 16221400.0 6686400.0 5858300.0 3676700.0 True False 5560037.857744275 5826740.175118491 4445480.970859944 1.0 1.047967716083577 0.7995414931695249 22.406663275473313 -6.856647529587781 1.2024987565214522 1.0258285139745449 0.7882559932046079 0.9494393957513062 0.024194627237669915 0.15029682528664728 0.4148817934696173 0.015712411499215338 0.03655135346696564 1.3910811650948772e-07 6.856647529587781 -0.23757252076993696 QK(ub)VWSEVNQAVLDYENR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKVWSEVNQAVLDYENR 17 1 Q9NWU2 Q9NWU2 GID8 Glucose-induced degradation protein 8 homolog 1 38044000.0 8875000.0 17332000.0 11837000.0 True False 11488862.45240429 16367458.963947514 9682787.457876526 1.0 1.4246370371091241 0.8427977528663158 23.4537326235951 -6.71103565944309 1.7915580087496907 1.260779964312953 0.844124698473928 0.47001586765048653 0.17891072086212662 0.37298926286480766 2.3343367280979574 0.07945208451852952 0.20158914357881383 1.9452003567997073e-07 6.71103565944309 -0.4166552658390249 QK(ub)YFLVGAGAIGCELLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QKYFLVGAGAIGCELLK 17 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 49240000.0 16431000.0 15238000.0 17571000.0 True False 24927028.267003283 12518659.844962582 14098084.1483571 1.0 0.5022122858316785 0.5655742031238915 24.571207563085576 -10.34157896337059 5.758666611382228 1.000075310955473 0.5338932444781626 0.9863299739568301 0.02586739441506488 2.5015236429750574e-05 2.8601076098663444e-06 0.02505001878735206 0.008348665648276167 4.5542937252351674e-11 10.34157896337059 -0.4661820664773104 QK(ub)YFLVGAGAIGCELLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QKYFLVGAGAIGCELLK 17 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 14599000.0 2284900.0 7953400.0 4360700.0 True False 3129689.2771007614 7601992.489623333 3330792.471435593 1.0 2.428992726289289 1.064256600745083 21.577587999441125 -6.6353702560401215 2.0608135170977255 1.9377208830014414 1.0698321631323835 0.1372126965398448 0.6121307853237026 0.5451572490109953 4.418894973681957 0.2423504266109971 0.6780228786174894 2.3154198062820297e-07 6.6353702560401215 -0.8678887198690579 QK(ub)YFLVGAGAIGCELLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKYFLVGAGAIGCELLK 17 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 40016000.0 16431000.0 12799000.0 10786000.0 True False 21270253.403431527 12086724.39877478 8823058.673705855 1.0 0.568245435046149 0.4148074076203734 24.342333885178025 -13.999999999994152 0.14410893026675733 3.071123190212857 0.2340015844262291 0.9995870726428432 0.005034360665186073 11.940456065276571 0.11922059977444249 6.93990624026244 0.1621257052897663 1.0000000000134649e-14 13.999999999994152 -2.8371216057866278 QK(ub)YPEHAIHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QKYPEHAIHK 10 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 5705200.0 1026800.0 2590900.0 2087500.0 True False 1346144.7435453446 2204347.8192490977 1871505.5247139463 1.0 1.637526595723653 1.3902706478539282 20.360402112681015 -10.226107314833872 4.98594938751685 0.9999288352286303 1.5138986217892332 0.8520645227583958 0.10094181802650674 7.986716572063117e-05 1.2396570598168014e-05 0.09774996439480475 0.03257883167914122 5.941453262519105e-11 10.226107314833872 0.5139697865606029 QK(ub)YPEHAIHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QKYPEHAIHK 10 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 7112700.0 1853600.0 2481000.0 2778100.0 True False 1794758.4826093423 3471676.2382440823 2050432.2687864557 1.0 1.9343417356059645 1.1424558171222 20.77535828558145 -10.160193320362183 4.276169502310584 0.99986468379872 1.5383987763896052 0.3813189764859698 0.3232860725944626 46371449.748438515 36726312.60803499 53216.525735657786 0.11066942186668284 6.915230801755446e-11 10.160193320362183 0.5385340925908852 QK(ub)YPEHAIHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QKYPEHAIHK 10 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 2363460.0 430880.0 394780.0 1537800.0 True False 653676.4615474644 324328.4245697815 1233853.1559583154 1.0 0.4961604763952963 1.8875594097994357 19.31821722206283 -6.808753468893604 1.419852050535692 0.7250019422034455 1.9111918761998359 0.8565154551663565 0.2178788092221372 0.20851364026782823 0.8287378354919466 0.12066985600138301 0.2792841282627515 1.553268486349025e-07 6.808753468893604 1.1861899339963904 QK(ub)YPEHAIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QKYPEHAIHK 10 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 5956500.0 1026800.0 2269400.0 2660300.0 True False 1406435.7082266444 2169130.404097765 2031991.9305983223 1.0 1.5422890583692532 1.4447812429054672 20.423612174203907 -10.046281919003418 4.826343905366787 0.9999878942309735 1.4935351506439138 0.9715572016090669 0.039807398996938984 5.273975565661997e-06 1.0422643929771567e-06 0.03854430962733668 0.012847782777075129 8.989138689028155e-11 10.046281919003418 0.4935472564129404 QK(ub)YPEHAIHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKYPEHAIHK 10 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 1380480.0 430880.0 280680.0 668920.0 True False 557782.6539145875 265059.91126245086 547183.4236988066 1.0 0.4752028579630932 0.9809975621482773 19.08934354415528 -10.797982126747758 10.308468945488574 1.0022486087651217 0.7281002100556853 0.27813882184809935 0.2064898233092767 0.010728807168196968 0.00021025482735181084 0.20101425815922197 0.06664430390317841 1.5922742552468598e-11 10.797982126747758 -0.2741483987094364 QK(ub)YPHLQVIGGNVVTAAQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QKYPHLQVIGGNVVTAAQAK 20 1 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 1 17034500.0 2859500.0 7129300.0 7045700.0 True False 3748832.1914373934 6065636.229793738 6316678.551126737 1.0 1.618006867218035 1.684972340334276 21.838009817196248 -11.423478706634535 0.37788402449767444 2.7369702875741e-14 1.6921704984154864 0.9995789465874106 0.0063267919844164295 3.74077080222836 0.1909185699203268 3.0952001602965593 0.018239584312293448 3.7715623644760185e-12 11.423478706634535 1.692170498415459 QK(ub)YPHLQVIGGNVVTAAQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QKYPHLQVIGGNVVTAAQAK 20 1 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 1 25290900.0 6191700.0 7221200.0 11878000.0 True False 5995147.872665234 10104662.818060523 8766795.467638144 1.0 1.6854734916769187 1.462315134479032 22.515363908039536 -10.203627245260828 4.895321120574189 0.9999275040705067 1.573894313079054 0.8981475619043218 0.0911040178325839 7.209526473055363e-05 1.1728293099259973e-05 0.0882221682259057 0.02940369531930335 6.25709508530304e-11 10.203627245260828 0.5739668090085472 QK(ub)YPHLQVIGGNVVTAAQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QKYPHLQVIGGNVVTAAQAK 20 1 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 1 13143000.0 2859500.0 3544900.0 6738600.0 True False 3916734.425081898 3388274.596583315 5147081.465823357 1.0 0.8650764205215337 1.3141257249566347 21.90121987871914 -6.82616496981197 1.3451354890174945 0.927694954957467 1.3252749043366339 0.8979473235731077 0.06009833592738607 0.1855942572105221 0.6581225975900733 0.03509423394368731 0.08077909210803509 1.4922274688134532e-07 6.82616496981197 0.39757994937916685 QK(ub)YPHLQVIGGNVVTAAQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QKYPHLQVIGGNVVTAAQAK 20 1 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 1 16835100.0 6191700.0 6506500.0 4136900.0 True False 5148672.888818391 6471448.1930608675 5001906.663135552 1.0 1.256915778649525 0.9714943580895229 22.295769183473812 -6.669512117467427 1.9388626741808153 1.164054752397272 0.9726444956280607 0.27698105381661986 0.10914409805313659 0.46224419293195723 3.3495141884657222 0.04532385024412558 0.12118164223669042 2.1403652065389758e-07 6.669512117467427 -0.1914102567692113 QKEQDVEK(ub)ELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QKEQDVEKELR 11 2 J9JIE5;Q14494-2;Q14494;J3QRG7;J3QQQ1;J3QKY3;B4DYE1;F5H1B7 J9JIE5 NFE2L1 Nuclear factor erythroid 2-related factor 1 1 6435900.0 1538200.0 2048100.0 2849600.0 True False 1489370.6829681112 2865917.0107004032 2103204.2738324343 1.0 1.9242469611319488 1.4121429257899967 20.50627143400609 -10.291524191194139 5.007821880861024 0.9998107732512919 1.668194943461236 0.6941909968344846 0.2090655969689105 0.00044181077958541554 6.250524958003887e-05 0.20248323917367608 0.06747563127699453 5.110646107789411e-11 10.291524191194139 0.6683841702099441 QKEQDVEK(ub)ELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QKEQDVEKELR 11 2 J9JIE5;Q14494-2;Q14494;J3QRG7;J3QQQ1;J3QKY3;B4DYE1;F5H1B7 J9JIE5 NFE2L1 Nuclear factor erythroid 2-related factor 1 1 44875200.0 4346400.0 33670000.0 6858800.0 True False 6593806.564402842 27661325.43508929 5503155.173681168 1.0 4.195046543285183 0.8345945729421853 22.652680134119844 -6.657629334243151 1.981603948208553 3.0606638607719003 0.8487457171931451 0.22544414263595747 1.3611631234004848 0.49009556409912114 3.697096189614848 0.5554842752635322 1.5082665884952602 2.199736523727447e-07 6.657629334243151 -2.2119181435787554 QKEQDVEK(ub)ELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKEQDVEKELR 11 2 J9JIE5;Q14494-2;Q14494;J3QRG7;J3QQQ1;J3QKY3;B4DYE1;F5H1B7 J9JIE5 NFE2L1 Nuclear factor erythroid 2-related factor 1 1 65176100.0 4346400.0 54883000.0 5946700.0 True False 5626500.480352676 51828712.80396563 4864461.6182947075 1.0 9.211536191092078 0.8645625527414507 22.423806456212294 -6.649920280413995 2.0086892720370586 6.328853027077944 0.899582867610996 0.1937259314376678 3.5048539212942407 0.508764260148423 3.9345868082204722 1.4150801601483798 3.882361525000537 2.2391321184698983e-07 6.649920280413995 -5.429270159466948 QKLEEDAEMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QKLEEDAEMK 10 1 P05455 P05455 SSB Lupus La protein 0 3681900.0 395500.0 1897200.0 1389200.0 False True 518504.3300274481 1614145.1552276781 1245458.910147361 1.0 3.1130794127451744 2.402022197348728 18.98399651146575 -10.151850838676843 5.46573361245402 0.9999593415790202 2.7575508050473045 0.8906628114340698 0.2902878926088368 0.0001438274509799988 2.2317333102472156e-05 0.28107646840433226 0.09369001447312598 7.049351420486722e-11 10.151850838676843 1.7575914634682843 QKLEEDAEMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QKLEEDAEMK 10 1 P05455 P05455 SSB Lupus La protein 0 2571710.0 395500.0 786310.0 1389900.0 False True 541727.0379856231 751568.2242205485 1061634.2458890378 1.0 1.3873559403924276 1.959721725975975 19.047206572988642 -6.965506218019801 0.3492624533594373 0.9442162306055457 2.422153032315023 0.9999231955762666 0.003454900651402684 0.07778967871487198 0.014257070585084552 0.007871464424111824 0.04922054216316551 1.0826642139501174e-07 6.965506218019801 1.4779368017094772 QKLSMIIK(ub)EEK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 QKLSMIIKEEK 11 2 Q6NT04-2;Q6NT04 Q6NT04-2 TIGD7 Tigger transposable element-derived protein 7 2 9713700.0 2800900.0 3573400.0 3339400.0 True False 3672007.0239541857 3040262.6490041064 2993870.921786715 1.0 0.8279566539963238 0.8153227655220489 21.80813738772028 -13.999999999999943 0.3705675912394284 3.404995208914265 0.8140246501102452 0.9997918667675784 0.0012152715431714288 22.885713303265458 0.19763567965143947 43.73322455017817 0.0035246068114475615 1.000000000000131e-14 13.999999999999943 -2.59097055880402 QKLSMIIK(ub)EEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 QKLSMIIKEEK 11 2 Q6NT04-2;Q6NT04 Q6NT04-2 TIGD7 Tigger transposable element-derived protein 7 2 24568900.0 8893500.0 8772100.0 6903300.0 True False 8611180.710555783 12274845.275897173 5095118.635439165 1.0 1.4254543817493444 0.5916864140585799 23.03777963371495 -6.767999817414013 1.5820825634917377 1.2446591713086281 0.5873472449407445 0.7228178435093362 0.17921848632647172 0.26969978415673235 1.331931104685327 0.08930545137315037 0.2129788946133268 1.7060831062740448e-07 6.767999817414013 -0.6573119263678836 QKLSMIIK(ub)EEK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QKLSMIIKEEK 11 2 Q6NT04-2;Q6NT04 Q6NT04-2 TIGD7 Tigger transposable element-derived protein 7 2 10233900.0 2800900.0 3803900.0 3629100.0 True False 3836468.421476442 3635831.1201848486 2771981.323660632 1.0 0.9477026058214291 0.722534638404205 21.87134744924317 -6.943187372158089 0.6292142232970561 1.0024562333343665 0.6556620559690545 0.9985522653845057 0.004580357784223932 0.08634221504845599 0.04821089290148732 0.004574746280637564 0.01912437237057161 1.139757943915576e-07 6.943187372158089 -0.34679417736531204 QKLSMIIK(ub)EEK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKLSMIIKEEK 11 2 Q6NT04-2;Q6NT04 Q6NT04-2 TIGD7 Tigger transposable element-derived protein 7 2 15850800.0 7059100.0 5971300.0 2820400.0 True False 9138144.105663914 5638991.905805444 2307116.139747821 1.0 0.6170828387692354 0.25247097365403187 23.12346976289783 -7.585039385025179 0.3130465924582746 1.0843238721716075 4.765053223691353e-10 0.9995440186623639 0.006517322308750338 0.12558626714930293 0.03800753405537617 0.02658195920860128 0.07082509065728877 2.599923772219853e-08 7.585039385025179 -1.0843238716951022 down QKVDSLLENLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QKVDSLLENLEK 12 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 38382700.0 1179900.0 17646000.0 19556800.0 False True 1546860.3261678529 15013285.58356927 17533249.93807221 1.0 9.705650425958464 11.334733745165329 20.560911503769663 -9.280226631247245 0.5705506510630838 1.0777582028549696e-21 11.22590234617132 0.9979267334440001 0.20657807818577384 0.658321220145978 0.24620806804120865 1.9883113409757842 0.29306834626117384 5.245336673591779e-10 9.280226631247245 11.22590234617132 QKVDSLLENLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QKVDSLLENLEK 12 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 41375500.0 14690000.0 3603900.0 23081600.0 False True 14223673.99089946 5042956.06409022 17035836.526842624 1.0 0.35454665702523736 1.1977099965692712 23.761790827047633 -6.702169491341369 1.8232673173765552 0.600045698436829 1.1952932697136454 0.42778195277406184 0.27234845381515377 0.39104631867149875 2.5288124609232727 0.11910331503356704 0.3054693847788367 1.985319958828076e-07 6.702169491341369 0.5952475712768164 QKVDSLLENLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QKVDSLLENLEK 12 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 40511800.0 1179900.0 23120400.0 16211500.0 False True 1616140.9155985753 22098864.279061448 12382677.586322878 1.0 13.673847413779894 7.66187989352195 20.624121565292555 -9.783113107508232 6.277702115943108 0.999999799461924 10.667863653657966 0.7751795599539644 2.454375462494834 60333060.21433557 94022485.21080732 134.45203866962225 0.8401980082125557 1.6477332005603453e-10 9.783113107508232 9.667863854196042 QKVEGTEPTTAFNLFVGNLNFNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QKVEGTEPTTAFNLFVGNLNFNK 23 1 P19338 P19338 NCL Nucleolin 0 24001400.0 9540200.0 10630000.0 3831200.0 False True 12507294.587428221 9044045.435415465 3434784.1754654306 1.0 0.7231016565729682 0.2746224734258617 23.576266422747857 -7.066951587466316 0.3983862095050091 1.0269027161676247 3.926437146882291e-13 0.9998495173703533 0.003666432538240001 0.0739503483689365 0.018446912844698383 0.006197242471945515 0.03573206312926219 8.571333879737611e-08 7.066951587466316 -1.0269027161672322 down QKVEGTEPTTAFNLFVGNLNFNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QKVEGTEPTTAFNLFVGNLNFNK 23 1 P19338 P19338 NCL Nucleolin 0 61137000.0 25712000.0 17170000.0 18255000.0 False True 24895786.634037208 24026070.540367164 13473467.861738874 1.0 0.9650657315450728 0.5411947033365926 24.569398265279084 -6.9232361088594505 0.8003706476898742 1.0083074729071049 0.46748379923585576 0.9950333489416153 0.01469653791586133 0.0963052433143925 0.09602417376387794 0.012884553429626234 0.03987411832540479 1.193339156427505e-07 6.9232361088594505 -0.5408236736712491 QKVEGTEPTTAFNLFVGNLNFNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QKVEGTEPTTAFNLFVGNLNFNK 23 1 P19338 P19338 NCL Nucleolin 0 175004000.0 32568000.0 90419000.0 52017000.0 False True 49408037.03972758 74283023.00312854 41735817.150139034 1.0 1.5034603164541773 0.8447171685161355 25.558242403475894 -6.702486054421919 1.8223786171144611 1.3118690501225891 0.8466064845924455 0.4292451962906433 0.21242195581578252 0.39035639693042284 2.5221607126742303 0.09293937677029075 0.23825157403543407 1.9838733597335138e-07 6.702486054421919 -0.46526256553014367 QKVEGTEPTTAFNLFVGNLNFNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QKVEGTEPTTAFNLFVGNLNFNK 23 1 P19338 P19338 NCL Nucleolin 0 53032200.0 9540200.0 15311000.0 28181000.0 False True 13067469.75421098 14634509.393293763 21525228.20591336 1.0 1.1199191326674243 1.647237652796317 23.639476484270748 -6.9427063763450745 0.6338922018391048 0.9942444544692346 1.8015218104897974 0.9984972618700227 0.010898473394305988 0.086553501327689 0.049149230259200476 0.010840512371188995 0.04487219318851809 1.1410209636389666e-07 6.9427063763450745 0.8072773560205628 QKVEGTEPTTAFNLFVGNLNFNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QKVEGTEPTTAFNLFVGNLNFNK 23 1 P19338 P19338 NCL Nucleolin 0 51736000.0 25712000.0 10095000.0 15929000.0 False True 21380667.234733302 10040616.231299393 19259680.252625443 1.0 0.4696119218855911 0.9007988404280352 24.34980354071336 -10.002006046506372 7.067121258228511 1.0000000278665375 0.6852053811568153 0.41543047564742197 0.17603132236533464 7.73207344106732e-08 1.0961073295703002e-08 0.17044161149147252 0.05681386499431741 9.953915588210795e-11 10.002006046506372 -0.31479464670972224 QKVEGTEPTTAFNLFVGNLNFNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QKVEGTEPTTAFNLFVGNLNFNK 23 1 P19338 P19338 NCL Nucleolin 0 110915000.0 32568000.0 41165000.0 37182000.0 False True 42159918.0112567 38874131.5630568 30415257.519537482 1.0 0.9220637372368087 0.7214259171807831 25.329368725568344 -6.954830250620183 0.5030295708728904 1.0039147708125566 0.6308764906086701 0.9995278439006818 0.0025498469787786646 0.08160220325010714 0.028369450543774734 0.00297354746696181 0.016552749497413644 1.1096084347205486e-07 6.954830250620183 -0.3730382802038865 QKYPHLQVIGGNVVTAAQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QKYPHLQVIGGNVVTAAQAK 20 1 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 12609200.0 3006300.0 5866900.0 3736000.0 False True 3941288.4130506134 4991581.38899708 3349434.558242547 1.0 1.2664846785809123 0.8498323916493178 21.9102358952661 -6.733956906923196 1.708905174993806 1.1596584361171474 0.8499000755284533 0.5774797570266771 0.11199305353489952 0.3288626297206325 1.8832437812876912 0.051897983353811815 0.128203418317073 1.8451985007961784e-07 6.733956906923196 -0.3097583605886941 QLAEEETK(ub)ITDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLAEEETKITDK 12 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 24700700.0 9315700.0 10853000.0 4532000.0 True False 12212972.91336714 9233774.704662655 4063072.114013705 1.0 0.7560628169867025 0.33268493616051986 23.54191109183487 -6.962719987723927 0.3952347648912602 1.0245327914915183 0.048874143190597734 0.999858159673154 0.003283417950067537 0.0787434128019354 0.0176431400361431 0.005453535302094467 0.03553726778869548 1.0896324096755937e-07 6.962719987723927 -0.9756586483009206 down QLAEEETK(ub)ITDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLAEEETKITDK 12 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 30227300.0 7555300.0 10766000.0 11906000.0 True False 7315461.137062129 15064919.943948332 8787461.427656155 1.0 2.059326085080997 1.2012177035753044 22.802517378210695 -10.264197093621037 4.7890224920975015 0.9998113089623801 1.6302718943292238 0.41836809199981806 0.35032127978610356 0.0007059835350699713 0.00010846981067155649 0.3392971673007273 0.11306570686894615 5.442556000801118e-11 10.264197093621037 0.6304605853668437 QLAEEETK(ub)ITDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLAEEETKITDK 12 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 21957500.0 9315700.0 8221000.0 4420800.0 True False 12759966.037326612 7857769.036788471 3376698.0892339493 1.0 0.6158142595209275 0.2646322160541905 23.60512115335776 -7.613396109094846 0.29704537482439025 1.0977607791299444 4.123580880296781e-13 0.9996109532771877 0.005923459142715931 0.1266670364206837 0.03683242654812435 0.02949188090014635 0.07276448714062972 2.4355883659932828e-08 7.613396109094846 -1.097760779129532 down QLAEEETK(ub)ITDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLAEEETKITDK 12 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 29362300.0 7555300.0 17455000.0 4352000.0 True False 6282566.706540939 17360966.450453777 5261983.078625529 1.0 2.763355689065559 0.8375530773349601 22.58292265364497 -6.665831779055216 1.9520299354735509 2.129517193320608 0.8454330627224981 0.26084123731671194 0.7497549850765762 0.4707118281203028 3.45373274640123 0.3096524198989656 0.831872626178999 2.1585803583202908e-07 6.665831779055216 -1.2840841305981097 QLAEEETK(ub)ITDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLAEEETKITDK 12 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 42231100.0 19001000.0 18914000.0 4316100.0 True False 24597169.065705255 17861419.27325777 3530614.0869258186 1.0 0.7261575194098722 0.14353741593167313 24.551988946853825 -7.24083141761917 0.5582925754936723 1.0047315692934977 2.2463984694610394e-24 0.9981829328495655 0.015223984951898802 0.09254257517224132 0.05182283445113627 0.015393308645144804 0.054131450718245364 5.7433936328364256e-08 7.24083141761917 -1.0047315692934977 down QLAHIYHYYIHGPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLAHIYHYYIHGPK 14 0 A6NHR9-2;A6NHR9 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 0 7266700.0 1895800.0 3110000.0 2260900.0 False True 2485412.158953316 2646000.1226850515 2026963.756084199 1.0 1.0646122065321206 0.8155443147658118 21.245053684842933 -6.837812139173529 1.2924045288807322 1.0343892303839248 0.8076951804606396 0.9206434618388251 0.029728735562291185 0.17137082300820822 0.556954024101588 0.018042736872697984 0.04154837687267512 1.4527398869057274e-07 6.837812139173529 -0.22669404992328523 QLAHIYHYYIHGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLAHIYHYYIHGPK 14 0 A6NHR9-2;A6NHR9 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 0 6506840.0 2290400.0 889440.0 3327000.0 False True 2217692.505701575 1244598.0303683248 2455558.8921394255 1.0 0.5612130749274421 1.1072585066803933 21.080627911715982 -6.692777807927569 1.8564026301182446 0.7256300127073142 1.105444467830976 0.3835174798550677 0.18547235994228842 0.41072825299917964 2.7464095929399974 0.0798601937447319 0.20724721813216887 2.0287203801746343e-07 6.692777807927569 0.37981445512366185 QLAHIYHYYIHGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLAHIYHYYIHGPK 14 0 A6NHR9-2;A6NHR9 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 0 9847200.0 1895800.0 3430900.0 4520500.0 False True 2596728.492068634 3279311.4935308993 3452851.0026199 1.0 1.262862676458908 1.3296927318994571 21.308263746365824 -13.099480321075612 0.20422316329202403 1.5273757337998154e-13 1.3729277891622962 0.9994491479551629 0.0033399630968737127 8.63696264543857 0.1375659758432759 3.5077868039815345 0.041223551977356374 7.952793007291187e-14 13.099480321075612 1.3729277891621434 QLAHIYHYYIHGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLAHIYHYYIHGPK 14 0 A6NHR9-2;A6NHR9 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 0 6241800.0 2290400.0 2369300.0 1582100.0 False True 1904569.0819241297 2356536.110630773 1912909.7951961008 1.0 1.2373067131017554 1.0043793177948392 20.86103318715026 -10.876200290002425 2.753848406775515 0.9449082376210135 1.120843015396284 0.2640959965952011 0.09509221238128089 17611999.928809606 9608400.209519794 6275083.420487705 0.03414623793959763 1.329840974124562e-11 10.876200290002425 0.17593477777527056 QLALETIDINK(ub)DPYFMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLALETIDINKDPYFMK 17 1 Q15428;K7EMT0 Q15428 SF3A2 Splicing factor 3A subunit 2 1 4872100.0 1200500.0 2174800.0 1496800.0 True False 1573867.1256585377 1850328.3173040038 1341925.4943194436 1.0 1.1756572630169075 0.8526294707108486 20.585882315223376 -6.759053782934571 1.6162262497507427 1.1021525899567202 0.8515121548203209 0.6870178588605026 0.07387174648558574 0.2845100582430558 1.4645796540564566 0.03606782776085776 0.08675113375729486 1.7415911817615649e-07 6.759053782934571 -0.2506404351363992 QLALLK(ub)TNSAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLALLKTNSAVR 12 1 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 23697100.0 6433100.0 7884400.0 9379600.0 True False 8433856.398229009 6708078.253150489 8409088.967476385 1.0 0.795374966848984 0.997063332646045 23.0077610266388 -10.795907798751927 8.831616480605518 1.001635509895466 0.8962191497521912 0.2609180327285625 0.0823389305431004 0.0026903998147120743 6.217308979146321e-05 0.08089227845744011 0.02657477556149642 1.599897652784633e-11 10.795907798751927 -0.10541636014327471 QLALLK(ub)TNSAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLALLKTNSAVR 12 1 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 46102700.0 9939700.0 15449000.0 20714000.0 True False 9624169.664216707 21617866.265470717 15288381.993320135 1.0 2.2462058566826144 1.5885403652185541 23.198230645292703 -10.185909200351428 5.042656907007956 0.9999280002781101 1.917373110951575 0.721781915509208 0.2684908125908329 0.00021736473881901996 3.5092368640990776e-05 0.25998533374888894 0.08665503714732352 6.517646468047314e-11 10.185909200351428 0.9174451106734649 QLALLK(ub)TNSAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLALLKTNSAVR 12 1 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 164682000.0 18054000.0 26748000.0 119880000.0 True False 27389237.924196787 21974610.416922137 96185665.45472945 1.0 0.8023082087110155 3.5118051010011877 24.707105789390376 -6.8893464761488525 1.026205735658898 0.8521271175544698 3.741915304055425 0.9804779609956533 0.1723205351565647 0.11967641390829009 0.2249402944642591 0.1280509140623885 0.31850179757393676 1.2901895615383775e-07 6.8893464761488525 2.8897881865009554 up QLALLK(ub)TNSAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLALLKTNSAVR 12 1 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 28170800.0 6433100.0 6529700.0 15208000.0 True False 8811590.917990666 6241196.263169638 11616183.618591625 1.0 0.7082939189138886 1.3182844876371655 23.07097108816169 -6.776639347073706 1.5487278450533792 0.834110760649802 1.3226379604833076 0.7554147061592212 0.12319697379210989 0.2558223898588945 1.2116933650961685 0.06266575067543122 0.14830018630961397 1.6724789212294092e-07 6.776639347073706 0.48852719983350557 QLALLK(ub)TNSAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLALLKTNSAVR 12 1 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 35201700.0 9939700.0 11499000.0 13763000.0 True False 8265300.953371146 11437052.604627218 16640779.667077906 1.0 1.3837430323650126 2.0133301571179545 22.97863592072698 -6.963725293421459 0.379298156907083 0.956410716592559 2.4629013416876364 0.9998844027630204 0.004491256491011451 0.07839628193665307 0.016402103418070246 0.008199477045842308 0.05321747509834753 1.0871130435309159e-07 6.963725293421459 1.5064906250950774 up QLALLK(ub)TNSAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLALLKTNSAVR 12 1 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 126390000.0 18054000.0 23546000.0 84790000.0 True False 23371258.89754445 22235644.40140252 69359090.01886898 1.0 0.9514097849362643 2.96770877097067 24.478232111482825 -6.901378420568482 0.9525085548487958 0.9193107814072297 3.185382263293744 0.9872398148035378 0.1060985115796572 0.11039787920641303 0.17175100099264815 0.08332013411816998 0.21832408781586363 1.25493600424052e-07 6.901378420568482 2.266071481886514 up QLANQK(ub)QQHLAFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLANQKQQHLAFR 13 1 Q2NL82;I3L1Q5 Q2NL82 TSR1 Pre-rRNA-processing protein TSR1 homolog 1 3421280.0 596580.0 1285300.0 1539400.0 True False 782122.1572889388 1093538.2500601595 1380117.6549674969 1.0 1.3981680992783516 1.7645806887141302 19.577034429733356 -6.972120765464246 0.20118765634053284 0.7852168321913532 2.387661576396918 0.9999945411829199 0.0007294712715182355 0.07562038850115554 0.0065055856878575204 0.011780754987283594 0.03878308844989 1.066299571138614e-07 6.972120765464246 1.6024447442055645 QLANQK(ub)QQHLAFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLANQKQQHLAFR 13 1 Q2NL82;I3L1Q5 Q2NL82 TSR1 Pre-rRNA-processing protein TSR1 homolog 1 4860800.0 1101600.0 1192700.0 2566500.0 True False 1066630.310985355 1668951.3298483342 1894256.6566503895 1.0 1.5646952019454183 1.7759261453019013 20.024628800851595 -11.092138029449325 0.1876897601708279 5.102239732100564e-17 1.96296454261039 0.9994379137766638 0.007765507723472561 3.286431535637712 0.10701507050267091 1.5479620573376773 0.14444470890901034 8.088387894964182e-12 11.092138029449325 1.96296454261039 QLANQK(ub)QQHLAFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLANQKQQHLAFR 13 1 Q2NL82;I3L1Q5 Q2NL82 TSR1 Pre-rRNA-processing protein TSR1 homolog 1 3433180.0 596580.0 1650000.0 1186600.0 True False 817151.7479683018 1577097.5441796589 906349.5187941093 1.0 1.9299934780789776 1.1091569234815706 19.640244491256247 -10.227716627085675 4.432811593255982 0.9998463625782426 1.5195752006796936 0.3482040603169694 0.3351051210849143 0.0006493074938535465 0.00011312229185016997 0.32458520491416404 0.10815471262758286 5.919477483271924e-11 10.227716627085675 0.5197288381014511 QLANQK(ub)QQHLAFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLANQKQQHLAFR 13 1 Q2NL82;I3L1Q5 Q2NL82 TSR1 Pre-rRNA-processing protein TSR1 homolog 1 5075300.0 1101600.0 2275100.0 1698600.0 True False 916029.209154568 2262843.5847280053 2053769.4065609649 1.0 2.4702744870073023 2.2420348456535057 19.80503407628587 -10.46603916998082 8.663947928208996 0.999967933151755 2.356154666330398 0.9791984503517385 0.0931784433987727 5.772234338738975e-05 3.5575746214322246e-06 0.09022173638736979 0.030073213292414764 3.4194860002156694e-11 10.46603916998082 1.356186733178643 QLAPGMVQQMQSVCSDCNGEGEVINEK(ub)DR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLAPGMVQQMQSVCSDCNGEGEVINEKDR 29 1 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 27368200.0 4733500.0 9933700.0 12701000.0 True False 6205664.3392792065 8451630.681259328 11386822.3565949 1.0 1.3619219827543867 1.8349078735247046 22.56515423377804 -6.967446326637827 0.3132377640452849 0.9298633127504699 2.282072201088793 0.9999550569180208 0.0022917649682827976 0.07714034199151253 0.011981860756823805 0.007376663528666186 0.04186247885591325 1.0778384528054237e-07 6.967446326637827 1.3522088883383232 QLAPGMVQQMQSVCSDCNGEGEVINEK(ub)DR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLAPGMVQQMQSVCSDCNGEGEVINEKDR 29 1 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 50730500.0 4733500.0 14067000.0 31930000.0 True False 6483602.868027681 13445473.426651651 24388791.618992034 1.0 2.0737657287670643 3.7616109615935085 22.62836429530093 -6.964467470541952 0.3670765091903774 0.8658244583200025 5.02803483471737 0.9999017444582219 0.01126717741542382 0.07814212753517244 0.01549991572954284 0.02235094008625251 0.14357653999183445 1.0852568343279458e-07 6.964467470541952 4.1622103763973675 QLAQIK(ub)EMVELPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLAQIKEMVELPLR 14 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 14409800.0 3360900.0 6082400.0 4966500.0 True False 4406172.447001897 5174929.629009505 4452614.222032008 1.0 1.1744727859053032 1.0105401628258357 22.071094529085144 -10.862757293636603 2.5556897071700857 0.9587692859531208 1.0925064741164359 0.2980351310386765 0.06692521619500695 50779237.10971298 25522817.604642518 12656647.341796804 0.025275872771994747 1.3716481003698988e-11 10.862757293636603 0.13373718816331504 QLAQIK(ub)EMVELPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLAQIKEMVELPLR 14 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 47155000.0 20339000.0 12915000.0 13901000.0 True False 19693349.57800574 18072026.850835275 10259911.07893904 1.0 0.9176715611151687 0.5209835451454986 24.231205179645485 -6.940633994346577 0.6536382402626737 1.004408655521964 0.41198411875468377 0.9982457742151343 0.008758844161077601 0.08747857432737952 0.05330132328409632 0.008567607137280766 0.03404789346577043 1.1464787398821609e-07 6.940633994346577 -0.5924245367672802 QLAQIK(ub)EMVELPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLAQIKEMVELPLR 14 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 15799400.0 3360900.0 5685400.0 6753100.0 True False 4603515.55490741 5434200.228896384 5158156.8644602215 1.0 1.180445718947002 1.120482119140785 22.134304590608036 -10.145090694925065 4.292113544204053 0.9999690784122214 1.150463919054215 0.8935620151572219 0.02448003716048859 17116296.187898263 0.30167717488168483 5449.515840478712 0.008380167843405822 7.159938716067289e-11 10.145090694925065 0.1504948406419936 QLAQIK(ub)EMVELPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLAQIKEMVELPLR 14 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 39140300.0 20339000.0 12688000.0 6113300.0 True False 16912779.670474537 12619647.225629177 7391562.765294449 1.0 0.7461604462133394 0.4370400909436703 24.01161045507976 -6.968489337112124 0.29202360319750226 1.0589566378626603 0.11466630785398434 0.9999680837367978 0.0013004702351033359 0.07679598493128147 0.010775613704464195 0.005342512690728349 0.027967428843998283 1.0752529999025196e-07 6.968489337112124 -0.9442903300086759 down QLAQYHAK(ub)DPNNLFMVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLAQYHAKDPNNLFMVR 17 1 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 37850000.0 12178000.0 10092000.0 15580000.0 True False 11791416.055900168 14121788.22908476 11499130.61001871 1.0 1.1976329358693543 0.9752120148677813 23.491233649208567 -6.672329273001123 1.9296829707945768 1.1258976975614976 0.9761120622110119 0.2892237700203133 0.08390579413895392 0.45575184065262386 3.274151197138782 0.03498234936635371 0.09316183224365478 2.1265261469382668e-07 6.672329273001123 -0.14978563535048572 QLAQYHAK(ub)DPNNLFMVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLAQYHAKDPNNLFMVR 17 1 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 141506000.0 17509000.0 57848000.0 66149000.0 True False 26562433.07935983 47524572.43151311 53074621.15586339 1.0 1.7891648814521355 1.9981084186562972 24.66288396566887 -10.860219783877982 0.2614665712025641 1.175927956384593e-13 2.0904157520641693 0.9991969488063328 0.012180129614047661 2.699556867013142 0.13540009513960227 1.7520816417631233 0.08985592247852386 1.379685868779604e-11 10.860219783877982 2.0904157520640516 QLAQYHAK(ub)DPNNLFMVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLAQYHAKDPNNLFMVR 17 1 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 34954000.0 12178000.0 12191000.0 10585000.0 True False 10126546.576873917 12125324.663275978 12798274.560489701 1.0 1.1973800319021577 1.2638340685379588 23.271638924642843 -13.999999999999998 0.15203848964615727 0.04246461582661738 1.3352605054636248 0.9995595762533466 0.0023513657126417436 11.96614111688327 0.1229041875013373 3.3831585725326847 0.06451143536087575 1.0000000000000041e-14 13.999999999999998 1.2927958896370075 QLAQYHAK(ub)DPNNLFMVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLAQYHAKDPNNLFMVR 17 1 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 113745000.0 17509000.0 49293000.0 46943000.0 True False 22665745.653988395 46549801.21797056 38399855.67585524 1.0 2.0537511506831625 1.6941801192893111 24.434010287761318 -10.424819592561777 4.820831886776032 0.9985254948053468 1.8739656349864486 0.8873486878281224 0.14679425886759812 0.0023296638500683673 0.0002779548990680553 0.1423340760754902 0.047377643325985104 3.759935608850684e-11 10.424819592561777 0.8754401401811018 QLASGLLLVTGPLVLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLASGLLLVTGPLVLNR 17 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 467470000.0 247300000.0 100640000.0 119530000.0 False True 239449596.86517635 140826076.8306668 88221507.17686372 1.0 0.5881240923949429 0.368434561309942 27.835146765768656 -10.117098099642972 0.1380774156397089 1.7547061153324008 1.7990068993941123e-11 0.9997872974146336 0.0038179464228927616 1.7337603076169708 0.06595819233799792 0.6778486371269498 0.2146726006868106 7.636632657159839e-11 10.117098099642972 -1.7547061153144108 QLASGLLLVTGPLVLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLASGLLLVTGPLVLNR 17 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 414370000.0 107650000.0 167210000.0 139510000.0 False True 163312920.26918063 137370069.0823069 111935787.3505948 1.0 0.8411463640224337 0.6854068077779552 27.283063691277842 -6.971368647563552 0.22309396890898137 1.0690724864398786 0.4530671299916622 0.9999911765325076 0.00038146148538085464 0.07586107708828851 0.007421041845919025 0.004213469945466826 0.015683248306579783 1.0681478051658375e-07 6.971368647563552 -0.6160053564482164 QLASGLLLVTGPLVLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLASGLLLVTGPLVLNR 17 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 161732000.0 63620000.0 20039000.0 78073000.0 False True 87142033.26585421 19153610.719888564 59633765.36390748 1.0 0.21979761088950545 0.6843283674822678 26.376865439942726 -10.325154817042232 5.565744610512285 1.0000960980767957 0.4520629891993594 0.6497515282603357 0.1896438872469057 0.00022617994590247212 2.742424541203108e-05 0.18365382657025994 0.061207301418104904 4.729826203380331e-11 10.325154817042232 -0.5480331088774363 QLASGLLLVTGPLVLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLASGLLLVTGPLVLNR 17 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 305979000.0 107650000.0 118220000.0 80109000.0 False True 139355047.09874058 111640953.07626809 65529983.987752885 1.0 0.8011260115836669 0.4702376078372056 27.05419001337029 -6.963478048984961 0.3832820191338904 1.0219065766500681 0.23769488639532657 0.9998782437092804 0.0024110093977586953 0.07848135211790182 0.016705323947697255 0.004292767289902999 0.02791663090782458 1.087732114660633e-07 6.963478048984961 -0.7842116902547416 down QLCDNAGFDATNILNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLCDNAGFDATNILNK 16 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 31498600.0 3401600.0 14702000.0 13395000.0 False True 4459530.541141262 12508518.907947136 12009013.893912984 1.0 2.8048958948817995 2.692887464975112 22.088460413636703 -10.40401196863947 4.644068016182744 0.9970149338675197 2.748891679929888 0.9969330770057797 0.04572725003184473 0.0014142313466958655 0.00018149277581332103 0.04430491104803902 0.014758406486074438 3.944464314509029e-11 10.40401196863947 1.751876746062368 QLCDNAGFDATNILNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLCDNAGFDATNILNK 16 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 12647900.0 6305800.0 1557400.0 4784700.0 False True 6105625.830620406 2179277.94173371 3531443.5320767993 1.0 0.3569294945662055 0.578391737398353 22.54170774929654 -10.117324052088456 5.187910863172751 1.0000140263431292 0.46766061598167086 0.8851103569697643 0.09041158204076949 1.4668193438662592e-05 2.4954389755677623e-06 0.08754294297377423 0.02918021262868978 7.632660543530197e-11 10.117324052088456 -0.5323534103614583 QLCDNAGFDATNILNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLCDNAGFDATNILNK 16 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 26703600.0 3401600.0 11861000.0 11441000.0 False True 4659263.444783559 11336941.800918125 8738871.434791341 1.0 2.4332047190014108 1.8755907534216056 22.151670475159595 -9.88400740157227 5.687676922434529 0.9999994812779286 2.154397736214074 0.8510697934148496 0.22764494819580172 1.497014087781035e-06 2.9393210214631466e-07 0.22041637182192514 0.0734720910995618 1.3061486275776657e-10 9.88400740157227 1.1543982549361456 QLCDNAGFDATNILNK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLCDNAGFDATNILNKLR 18 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 19679700.0 6817000.0 4106300.0 8756400.0 True False 6600598.066437138 5745967.004071606 6462836.153630805 1.0 0.8705221778748841 0.979128874168717 22.65416531930925 -10.070310344164731 4.7443506797955255 1.000002919418594 0.9248255260253404 0.3897981855768945 0.044338498099506234 1.3692263774708193e-06 2.6827958145141205e-07 0.042932233298002984 0.014310188727281022 8.505300374596495e-11 10.070310344164731 -0.07517739339325358 QLCDNAGFDATNILNK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLCDNAGFDATNILNKLR 18 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 101143000.0 11253000.0 15557000.0 74333000.0 True False 17071623.704496875 12780731.802604213 59641049.96868867 1.0 0.7486535565587479 3.4935780568416863 24.02509694571851 -6.884520112703592 1.0542929123173175 0.8325603228272525 3.705769505032153 0.9771513284898796 0.1872819564103357 0.12370043871566082 0.24874229695571004 0.13623546621906973 0.333573720616608 1.3046075492847567e-07 6.884520112703592 2.8732091822049006 up QLCDNAGFDATNILNK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLCDNAGFDATNILNKLR 18 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 22064600.0 6817000.0 6105100.0 9142500.0 True False 5668637.544305265 6072210.614532537 11054154.479856122 1.0 1.0711940156824284 1.9500549106303626 22.434570594743526 -6.922988877921468 0.802243706697338 0.9826173600459268 2.1020051010164815 0.9949718092770502 0.03063713984525019 0.09644481544520213 0.09673286353940144 0.026823841289366334 0.08279762356881407 1.1940186823326583e-07 6.922988877921468 1.1193877409705548 QLCDNAGFDATNILNK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLCDNAGFDATNILNKLR 18 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 89710000.0 11253000.0 14961000.0 63496000.0 True False 14567230.32979217 14128407.198224045 51940379.52397814 1.0 0.9698760078866423 3.565563140561612 23.79622326781096 -6.9042739817735495 0.9338385779656004 0.9043675315642024 3.8629772139311105 0.9885756784699139 0.13003374342590293 0.10832775185386832 0.16020279324884457 0.10353395071396235 0.2756436622113626 1.2465968301337036e-07 6.9042739817735495 2.958609682366908 up QLDDLK(ub)VELSQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLDDLKVELSQLR 13 1 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 1 47686600.0 2686400.0 5370200.0 39630000.0 True False 3521896.415134607 4568987.092875645 35529467.75780296 1.0 1.2973087661639866 10.088163753233221 21.747921047042627 -6.914085797870797 0.8674553896306237 0.761715333734129 11.329381520366427 0.9923741172819941 0.36815656605011515 0.1017775746962783 0.12457287470974865 0.30764171318923716 0.8753003303494997 1.2187488029068737e-07 6.914085797870797 10.567666186632298 up QLDDLK(ub)VELSQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLDDLKVELSQLR 13 1 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 1 72111500.0 6533500.0 15786000.0 49792000.0 True False 6326097.618757081 22089432.12290249 36749981.47201871 1.0 3.491794381643214 5.809265630529293 22.592884387748263 -7.237051819750778 0.23551898499280166 2.678173106244095e-12 8.754730038486821 0.9999684336866524 0.01103341852703454 0.10117984386229781 0.013475333088898303 0.11123606001379116 0.33777955808558724 5.793595634753204e-08 7.237051819750778 8.754730038484142 QLDDLK(ub)VELSQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLDDLKVELSQLR 13 1 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 1 126248000.0 23565000.0 41163000.0 61520000.0 True False 35749827.8322642 33817141.04201305 49360545.03482611 1.0 0.9459385706885306 1.3807211958172914 25.0914329582386 -6.875753414284149 1.1032669417638161 0.968056817861903 1.409124081219733 0.9700929067532204 0.0334596186153783 0.13145535826486748 0.29561673877988076 0.023445454025709044 0.05613108863280113 1.3312100439950312e-07 6.875753414284149 0.44106726335783 QLDDLK(ub)VELSQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLDDLKVELSQLR 13 1 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 1 53172300.0 2686400.0 7326900.0 43159000.0 True False 3679634.677230287 7003173.331181784 32965733.08750631 1.0 1.9032251692043438 8.95896902252266 21.81113110856552 -6.930541761394569 0.7423308216691968 0.8948319577053704 10.427669592753357 0.9966436705699359 0.2061378616694664 0.09235748219899337 0.07630895503065059 0.18841032881605396 0.6365317288596565 1.1734328407443166e-07 6.930541761394569 9.532837635047986 QLDDLK(ub)VELSQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLDDLKVELSQLR 13 1 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 1 61030500.0 6533500.0 10111000.0 44386000.0 True False 5432894.733125779 10056530.036123635 53666907.38232364 1.0 1.851044522325519 9.878142319802826 22.37328966318254 -6.927168426934353 0.7696845592893345 0.8642609300331298 11.41318830992167 0.9959517948963577 0.2544843407998175 0.09413495397849274 0.08508149876972708 0.22805560920527956 0.7379452169620019 1.1825828406406786e-07 6.927168426934353 10.548927379888541 up QLDDLK(ub)VELSQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLDDLKVELSQLR 13 1 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 1 148861000.0 23565000.0 40104000.0 85192000.0 True False 30505357.03559519 37872177.145750724 69687930.14373729 1.0 1.2414926696828874 2.28444892686953 24.86255928033105 -6.94311676600066 0.6298991233264809 0.9886230750019871 2.5935186140523694 0.998544317274553 0.021265313277637022 0.08637304732245224 0.04834724806997284 0.021226414117860703 0.08860663237392248 1.1399432570478391e-07 6.94311676600066 1.6048955390503823 up QLDDLKVELSQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLDDLKVELSQLR 13 1 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 0 10536800.0 2199800.0 2993100.0 5343900.0 False True 2883959.1028935043 2546541.14701242 4790964.490308438 1.0 0.8830018235894713 1.6612456416256447 21.459619275348444 -6.868607192847812 1.141354460550844 0.9343479768604486 1.7056492086032184 0.9632776228625347 0.06565971456593223 0.13820179847906847 0.3373387196362898 0.04468068608057689 0.105541545540177 1.3532960280364233e-07 6.868607192847812 0.7713012317427699 QLDFNSSK(ub)DVAVMQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLDFNSSKDVAVMQLR 16 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 13241000.0 2726900.0 4561000.0 5953100.0 True False 2640336.052129592 6382231.085300782 4393804.520828136 1.0 2.4172040828488948 1.6641080658214946 21.332290131440647 -10.058771129953751 4.930128950251546 0.9999761810005062 2.040656074343891 0.7179893449754509 0.3074501615366573 8.049531725356751e-05 1.536844451642111e-05 0.29769412997025085 0.09922911294739421 8.734315392187785e-11 10.058771129953751 1.0406798933433845 QLDFNSSK(ub)DVAVMQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLDFNSSKDVAVMQLR 16 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 14784300.0 2726900.0 5657400.0 6400000.0 True False 2267538.172152857 5626922.463294026 7738210.40974342 1.0 2.481511681874659 3.412604252830095 21.112695406874924 -8.452900812899427 0.20902829743816673 4.7488202086052573e-17 4.434117538308093 0.9996581436158195 0.018368235301438662 0.1422929427549962 0.05301095350594513 0.48881466322456685 0.4261064655894646 3.5245135706733265e-09 8.452900812899427 4.434117538308093 QLDFNSSK(ub)DVAVMQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLDFNSSKDVAVMQLR 16 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 21894700.0 5498600.0 4574100.0 11822000.0 True False 7118046.093610173 4319547.314042952 9670517.303963529 1.0 0.6068445268878749 1.3585915540283862 22.76304984451628 -6.764562530881164 1.5950353702721656 0.7729386137926807 1.3620022377013516 0.7094329880573782 0.1654901727354785 0.27530655009722266 1.3813442980888355 0.08182032013745286 0.19577223557702234 1.7196397250851077e-07 6.764562530881164 0.589063623908671 QLDK(ub)CSIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLDKCSIER 9 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 1039782440.0 364296000.0 384421000.0 291065440.0 True False 477595583.8474818 327066885.2613216 260948780.36565068 1.0 0.6848197435715174 0.5463802204020873 28.831214255687392 -13.999999999978762 0.11173641705487079 2.5164165366174673 0.29865064601321273 0.9997342529110467 0.003094346769442655 12.002681419569504 0.10171394050115151 4.093243853763668 0.21994954900697355 1.0000000000489026e-14 13.999999999978762 -2.2177658906042548 QLDK(ub)CSIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLDKCSIER 9 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 693660000.0 256582000.0 281640000.0 155438000.0 True False 248436944.85588592 394100320.73319745 114724124.75995447 1.0 1.586319301108007 0.46178367241838364 27.88830449061649 -6.765020297113908 1.5934403203825025 1.338440881476932 0.45660989107701744 0.7111303323783038 0.24682035260499213 0.27458604829471944 1.3750835418525456 0.12214996649360654 0.29212491938395324 1.7178281011560896e-07 6.765020297113908 -0.8818309903999145 down QLDK(ub)CSIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLDKCSIER 9 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 3732350000.0 1374070000.0 1434290000.0 923990000.0 True False 2084564647.972811 1178329743.341081 741362971.5007969 1.0 0.5652641881301107 0.35564402966430164 30.957098968691223 -11.585481259820172 0.12598165445036213 2.18445900645808 1.665941058865965e-11 0.9997525282158497 0.00422155447614159 4.495748578061983 0.08289622486641797 1.7160733809813378 0.2572606197440558 2.5972798138382634e-12 11.585481259820172 -2.1844590064414207 QLDK(ub)CSIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLDKCSIER 9 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 1143047000.0 364296000.0 294497000.0 484254000.0 True False 498986075.92922974 281485148.7686527 369883178.7241893 1.0 0.5641142355414647 0.7412695395064474 28.894424317210284 -10.157498096744455 5.3013299129332525 1.0000118668208589 0.6526918875238081 0.8367241247348045 0.07232334999082786 1.0144053167357301e-05 1.612178077163689e-06 0.07002917272222915 0.023342260837959174 6.958280040960288e-11 10.157498096744455 -0.3473199792970507 QLDK(ub)CSIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLDKCSIER 9 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 848728200.0 256582000.0 222724200.0 369422000.0 True False 213359301.50989205 221524340.5273079 446666432.18566155 1.0 1.0382689620730563 2.093494068572176 27.668709766050767 -6.914581129985582 0.8639697039399156 0.9718686503635077 2.244114178420482 0.9925381948683062 0.043769531110324285 0.10146592916768829 0.12291692397593393 0.03666701299386814 0.10473574853332875 1.2173595582516319e-07 6.914581129985582 1.2722455280569744 up QLDK(ub)CSIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLDKCSIER 9 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 4494963400.0 1374070000.0 2007960000.0 1112933400.0 True False 1778760701.9690344 1896215260.8613033 910390940.8610188 1.0 1.0660316808001493 0.5118119260523596 30.728225290783673 -6.877154417349859 1.0954853526803547 1.0395753838924997 0.4746073457034246 0.9713194938859362 0.041859419472680126 0.13018349234009163 0.28773756936562994 0.02950489673187199 0.07086574045539686 1.32692257446325e-07 6.877154417349859 -0.5649680381890752 QLDK(ub)MGFNIGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLDKMGFNIGVR 12 1 O43617;A6NKE1 O43617 TRAPPC3 Trafficking protein particle complex subunit 3 1 9319300.0 3354900.0 2511400.0 3453000.0 True False 3248400.5358794117 3514215.116777988 2548555.7122204537 1.0 1.0818293735524873 0.7845571025096832 21.631298100708168 -6.8333017302182215 1.3129693066030186 1.0436360053401201 0.7759976872265825 0.9123341925106914 0.03712318322794832 0.1767762381450751 0.5947999628926289 0.022190929360685962 0.05107220977066948 1.4679060815903683e-07 6.8333017302182215 -0.26763831811353767 QLDK(ub)MGFNIGVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLDKMGFNIGVR 12 1 O43617;A6NKE1 O43617 TRAPPC3 Trafficking protein particle complex subunit 3 1 23020700.0 6565300.0 8557900.0 7897500.0 True False 9960040.087721791 7030675.881822117 6336555.663402788 1.0 0.7058883116835203 0.6361978071969969 23.247720118268237 -13.999999999999998 0.2022728324526434 2.649252964447261 0.5919378487564607 0.9994871674912488 0.0035703362818823134 12.576760615226982 0.1425974190248976 8.214245338726302 0.043634840717983146 1.0000000000000041e-14 13.999999999999998 -2.0573151156908 QLDK(ub)MGFNIGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLDKMGFNIGVR 12 1 O43617;A6NKE1 O43617 TRAPPC3 Trafficking protein particle complex subunit 3 1 9107200.0 3354900.0 3973100.0 1779200.0 True False 2789747.99727002 3951696.121701397 2151222.49390867 1.0 1.4165064821512305 0.7711171389006477 21.411703376142444 -6.732419083324701 1.7140581075644785 1.2499624011009434 0.7713002804440655 0.5706551528460905 0.1750580457437941 0.33169299658120305 1.9101656337888742 0.08089306859920944 0.20021020513034635 1.8517438744118057e-07 6.732419083324701 -0.47866212065687785 QLDK(ub)MGFNIGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLDKMGFNIGVR 12 1 O43617;A6NKE1 O43617 TRAPPC3 Trafficking protein particle complex subunit 3 1 22796700.0 6565300.0 5695400.0 10536000.0 True False 8498910.27141069 5378445.983341035 8618556.108489245 1.0 0.6328394831315586 1.0140777856522416 23.018846440360687 -10.972299115888529 11.801172441095714 1.0831655705739363 0.8234586343918904 0.2223443016947818 0.15563988526341388 0.08250030907484159 0.00019365276556221512 0.03650655159840085 0.05023255696923625 1.0658617669644986e-11 10.972299115888529 -0.2597069361820459 QLDSTIGIHPVCAEVFTTLSVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLDSTIGIHPVCAEVFTTLSVTK 23 0 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;Q16881-7;E2QRB9 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 39672400.0 6877400.0 21047000.0 11748000.0 False True 10433518.605288083 17290998.409038447 9426002.650668692 1.0 1.6572547635343984 0.9034346903729347 23.31472243935982 -6.676241040595323 1.9150417355458424 1.4172409503232735 0.906367490036245 0.30710081273967216 0.27879078585583505 0.4469243290355649 3.165507503512323 0.11695058738656122 0.3099655147545461 2.1074581512708228e-07 6.676241040595323 -0.5108734602870285 QLEAIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLEAIVR 7 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 3872720.0 937620.0 1875600.0 1059500.0 False True 1229228.8999249968 1595767.7910315394 949873.1034416411 1.0 1.2981860344553464 0.7727389939331877 20.22932216041125 -6.752744196418826 1.6395320909417077 1.174754967723392 0.771462011210718 0.660756401890808 0.12532102903650313 0.29528328367740897 1.5624602533659249 0.06035930965557034 0.14612541072682056 1.7670783401702722e-07 6.752744196418826 -0.40329295651267394 QLEAIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLEAIVR 7 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 2800170.0 937620.0 812350.0 1050200.0 False True 1284283.4522277631 776457.6909177846 802164.3895479297 1.0 0.6045843614748082 0.6246007360419285 20.29253222193414 -10.179437710559787 4.819475318929694 1.000042779881304 0.6145925487569486 0.9979811017886174 0.008171650703244594 3.7566452290378846e-06 6.396013375659578e-07 0.007913043121964301 0.0026373889230225968 6.615494145534965e-11 10.179437710559787 -0.3854502311243555 QLEALENDNFQDDPHAGLPQLGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLEALENDNFQDDPHAGLPQLGKR 24 1 O43257 O43257 ZNHIT1 Zinc finger HIT domain-containing protein 1 1 16361300.0 5815200.0 6539300.0 4006800.0 True False 5630599.659079546 9150476.591998998 2957298.878576571 1.0 1.6251335818634385 0.5252191698281762 22.42485714688913 -6.752535859449697 1.6405217117207773 1.3664603502638253 0.5226102518512143 0.6597975861384625 0.2627243162627226 0.29563644623153534 1.5661956775392483 0.12647067818124777 0.306216178195111 1.7679262350384092e-07 6.752535859449697 -0.8438500984126109 QLEALENDNFQDDPHAGLPQLGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLEALENDNFQDDPHAGLPQLGKR 24 1 O43257 O43257 ZNHIT1 Zinc finger HIT domain-containing protein 1 1 22568500.0 4611500.0 6478000.0 11479000.0 True False 5969677.656254914 6117493.605380347 9389939.784486337 1.0 1.0247611274237822 1.5729391644199981 22.509221601940265 -6.916349106981483 0.8513591341794268 0.9862412283465095 1.6543196765742825 0.9931052632948859 0.021957916559218305 0.10036814134587092 0.11709595267903959 0.018561893822953236 0.05380132358489262 1.2124138615436942e-07 6.916349106981483 0.668078448227773 QLEK(ub)AVSGKEPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLEKAVSGKEPR 12 2 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 6406500.0 1100800.0 1088800.0 4216900.0 True False 1669994.0792597684 894495.1331667728 3383427.8666670686 1.0 0.5356277272331776 2.0260118935073033 20.67141155715062 -6.822993802553042 1.3588243703062395 0.7504279502378803 2.0606956570186323 0.8911281585650949 0.20545823033245095 0.18962908283372562 0.6871501933800868 0.11879122064683266 0.27360706438465454 1.5031634163028648e-07 6.822993802553042 1.310267706780752 up QLEK(ub)ELQGQNVEAVDPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLEKELQGQNVEAVDPR 17 1 Q8IZ07 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 159486700.0 50394400.0 66816300.0 42276000.0 True False 66067546.42006382 56847568.48789746 37901685.060027234 1.0 0.8604461883063607 0.5736808329318706 25.97743843191243 -6.959511943424641 0.4422581007506695 1.0100154195264426 0.41288900676749035 0.9997516676018655 0.002796653206998494 0.0798759195678631 0.02177895838437467 0.003791700578099704 0.023750394729235288 1.0977111019783403e-07 6.959511943424641 -0.5971264127589522 QLEK(ub)ELQGQNVEAVDPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLEKELQGQNVEAVDPR 17 1 Q8IZ07 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 132084100.0 48085300.0 45446800.0 38552000.0 True False 46558858.47206251 63593944.24193105 28454074.664790884 1.0 1.3658828057412615 0.6111420167628177 25.4725523509611 -6.77485963323953 1.5556285764051454 1.2085522365258856 0.6060706655179656 0.7488859819681073 0.15442753473223286 0.25863744752160056 1.2357953996146258 0.07821393306985502 0.18538135939938338 1.679346706038085e-07 6.77485963323953 -0.60248157100792 QLEK(ub)ELQGQNVEAVDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLEKELQGQNVEAVDPR 17 1 Q8IZ07 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 295144500.0 114089600.0 109593000.0 71461900.0 True False 173082264.26700145 90035272.89598277 57337424.14213659 1.0 0.5201877458518331 0.33127267189945186 27.366882658471496 -13.999999999999998 0.12877451610665397 3.2799504739181153 0.06254596995323095 0.9996511990682491 0.005257073213187679 11.938766161133158 0.11147130095596769 6.897386158585226 0.23888322553630065 1.0000000000000041e-14 13.999999999999998 -3.217404503964884 QLEK(ub)ELQGQNVEAVDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLEKELQGQNVEAVDPR 17 1 Q8IZ07 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 125955200.0 50394400.0 39077500.0 36483300.0 True False 69026571.5374531 37350926.83798822 27866695.937149107 1.0 0.5411094018731901 0.40370969202822027 26.04064849343532 -13.999999999815058 0.16899239413970624 3.3081574900936856 0.28119813896015056 0.9995156368840536 0.005611124712041119 12.08188435787559 0.13015772222619051 9.140905149845354 0.11305639721305262 1.0000000004258443e-14 13.999999999815058 -3.0269593511335353 QLEK(ub)ELQGQNVEAVDPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLEKELQGQNVEAVDPR 17 1 Q8IZ07 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 159067160.0 48085300.0 81740200.0 29241660.0 True False 39985057.489978336 81299849.31844069 35355955.90784029 1.0 2.0332557815833403 0.8842292127928474 25.252957626395375 -6.669775611123047 1.9386232881217134 1.6596603558016925 0.8889219922632325 0.27791684414595164 0.4389286961969555 0.46159604521574693 3.344452445362849 0.18230876508940425 0.48714516871513397 2.139067005376065e-07 6.669775611123047 -0.7707383635384599 QLEK(ub)ELQGQNVEAVDPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLEKELQGQNVEAVDPR 17 1 Q8IZ07 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 276939900.0 114089600.0 113423300.0 49427000.0 True False 147691236.2422338 107111193.64790623 40431793.16384761 1.0 0.7252373016380554 0.27375891889437465 27.138008980563946 -7.0616047523401075 0.40164639184463913 1.0260110648975311 4.1199636830882757e-13 0.999846455984005 0.0037099244328975592 0.07371758434894439 0.018557255040502322 0.006163990009504484 0.03573697480383266 8.67751249425808e-08 7.0616047523401075 -1.0260110648971192 down QLENVLDDLDPESAMLPAGFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLENVLDDLDPESAMLPAGFR 21 0 Q9NZR1-2;Q9NZR1 Q9NZR1-2 TMOD2 Tropomodulin-2 0 69960800.0 32491000.0 31462000.0 6007800.0 False True 31459590.989674255 44024940.672162525 4434176.949863319 1.0 1.3994123663785871 0.1409483343670525 24.906996578416997 -6.821350923583763 1.3660389465946667 1.2149909065930375 0.1126749638838971 0.8874581420344659 0.17614464631471266 0.19173187483347423 0.702657551676252 0.10131967344483911 0.23344330885022235 1.5088604548078694e-07 6.821350923583763 -1.1023159427091405 down QLENVLDDLDPESAMLPAGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLENVLDDLDPESAMLPAGFR 21 0 Q9NZR1-2;Q9NZR1 Q9NZR1-2 TMOD2 Tropomodulin-2 0 99516400.0 32491000.0 65094000.0 1931400.0 False True 27017706.095353182 64743325.701852575 2335246.8102153786 1.0 2.396329483833858 0.08643394083767243 24.687401853851274 -6.7430554352611205 1.6756613283074853 1.8278533908071273 0.08419537705702017 0.6185394301529153 0.5866518172384984 0.3123045523559565 1.7229511357453322 0.2768468279347588 0.6770522825633313 1.8069434650648894e-07 6.7430554352611205 -1.7436580137501072 QLFDQVVK(ub)TIGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLFDQVVKTIGLR 13 1 P26038;V9GZ54;P15311;E7EQR4 P26038;P15311 MSN;EZR Moesin;Ezrin 1 3368830.0 851230.0 1324500.0 1193100.0 True False 1115970.7733230449 1126889.7628605624 1069649.457023336 1.0 1.0097842970430164 0.9584923571414178 20.089867813575466 -6.857305805504826 1.1992402272722178 1.0052752161952316 0.9561329679464939 0.9502839754086798 0.004957711963045425 0.14960382536674166 0.41037683142827364 0.003227650441749061 0.007513069327776803 1.3889742500249095e-07 6.857305805504826 -0.0491422482487377 QLFDQVVK(ub)TIGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLFDQVVKTIGLR 13 1 P26038;V9GZ54;P15311;E7EQR4 P26038;P15311 MSN;EZR Moesin;Ezrin 1 23599700.0 8742800.0 8584700.0 6272200.0 True False 13263466.784295322 7052693.212432763 5032496.920797077 1.0 0.5317382949066937 0.3794254550971418 23.660954578335488 -13.999999999999998 0.1570515907902836 3.2923388422978093 0.22471430019683292 0.999544436042389 0.005636221944850256 11.991293393412276 0.12512928235584186 8.37595895307177 0.14050172597727023 1.0000000000000041e-14 13.999999999999998 -3.0676245421009765 QLFDQVVK(ub)TIGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLFDQVVKTIGLR 13 1 P26038;V9GZ54;P15311;E7EQR4 P26038;P15311 MSN;EZR Moesin;Ezrin 1 7005030.0 851230.0 1865500.0 4288300.0 True False 1165952.734625794 1783076.0416164552 3275491.8603107883 1.0 1.529286727209164 2.8092835695968748 20.153077875098358 -6.956169751963208 0.4864251615833113 0.9710591142791118 3.421460462224201 0.9996006900172941 0.015177594806242685 0.08109891225252888 0.026411465668292326 0.01828930584569324 0.10557263165524763 1.1061913242991341e-07 6.956169751963208 2.450401347945089 QLFDQVVK(ub)TIGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLFDQVVKTIGLR 13 1 P26038;V9GZ54;P15311;E7EQR4 P26038;P15311 MSN;EZR Moesin;Ezrin 1 10593400.0 4544800.0 3279900.0 2768700.0 True False 3779202.568777847 3262230.5276908246 3347622.368977594 1.0 0.863206051626334 0.8858012525272438 21.849650419792596 -10.475633925467958 8.858051162374105 1.0000028429522823 0.87450365208309 0.976264458106617 0.009224452140483976 5.179197616309197e-07 3.0651941433425654e-08 0.008931739650841646 0.0029771791264984766 3.34476857718674e-11 10.475633925467958 -0.12549919086919226 QLFDQVVK(ub)TIGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLFDQVVKTIGLR 13 1 P26038;V9GZ54;P15311;E7EQR4 P26038;P15311 MSN;EZR Moesin;Ezrin 1 24528100.0 8742800.0 9147800.0 6637500.0 True False 11317726.946352703 8638716.888437519 5429543.106501275 1.0 0.7632908029488613 0.47973794846243584 23.432080900427938 -6.968724846292946 0.28701212116547753 1.0574220643245829 0.17688238973598044 0.9999706573742673 0.0011520638958818412 0.07671865505546464 0.01050381685682971 0.005034892529009598 0.025804061897037007 1.074670069851968e-07 6.968724846292946 -0.8805396745886024 down QLFEEQAK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLFEEQAKAK 10 1 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 1 5442600.0 1898600.0 1524100.0 2019900.0 True False 1838329.9822410971 2132681.078076503 1490827.5942988973 1.0 1.160118748363427 0.8109684380393113 20.80996432453288 -6.782007474765019 1.527907435649898 1.0904287109760706 0.80802043554664 0.7744468302996043 0.06777305424107961 0.24748406581588195 1.141262862927286 0.03493060220013374 0.08228923210647872 1.651933366092492e-07 6.782007474765019 -0.2824082754294306 QLFEEQAK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLFEEQAKAK 10 1 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 1 8601800.0 3263300.0 1978200.0 3360300.0 True False 4950664.679186405 1625174.7542528554 2696135.232128188 1.0 0.3282740519844575 0.5446006560418616 22.239190804615394 -10.209258706302272 6.448872137549527 1.000004482824735 0.4364373540132501 0.90048816372462 0.08831496628828947 5.692191526474466e-06 6.977862568715676e-07 0.08551127845856263 0.028503532804617676 6.176483615549052e-11 10.209258706302272 -0.5635671288114849 QLFEEQAK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLFEEQAKAK 10 1 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 1 2459610.0 1719600.0 0.0 740010.0 True False 2355382.5904426733 0.0 565234.8789843499 1.0 0.0 0.23997582442779244 21.16752998861179 -10.409016294220585 5.353967116255886 1.0006030880957195 0.11998791221420374 0.9471738830103283 0.09796972007534789 0.0007057061149674279 7.789735512678017e-05 0.09491847352173048 0.03161959119036217 3.899273567841111e-11 10.409016294220585 -0.8806151758815157 QLFEEQAK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLFEEQAKAK 10 1 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 1 6372940.0 1898600.0 3618400.0 855940.0 True False 1578770.0222411593 3598906.961003838 1034913.0965805895 1.0 2.2795637808570577 0.6555185885221382 20.590369599967158 -6.696646830202107 1.8429612201341843 1.7971559172637164 0.6606612463668179 0.40164586382735434 0.540457949825966 0.40252458845871525 2.6556095963847324 0.23417182589719146 0.6047034594402458 2.01072727842632e-07 6.696646830202107 -1.1364946708968984 QLFEEQAK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLFEEQAKAK 10 1 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 1 9515600.0 3263300.0 1796100.0 4456200.0 True False 4224406.17925982 1696145.4561012073 3645217.324473211 1.0 0.4015109779046857 0.8628946104590511 22.010317126707843 -9.921543255096827 6.660883801084657 1.000000024106455 0.6322027941818876 0.4586659865105186 0.18835907923835066 6.738267564939363e-08 1.1016008969083683e-08 0.18237790783745034 0.060792631416421106 1.197999798215636e-10 9.921543255096827 -0.3677972299245674 QLFGK(ub)STVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLFGKSTVK 9 1 O95147 O95147 DUSP14 Dual specificity protein phosphatase 14 1 7801100.0 1805600.0 3383300.0 2612200.0 True False 2367159.0854552737 2878524.828000109 2341914.6019917466 1.0 1.2160250849581091 0.9893355357404414 21.174725235297434 -6.65713923523184 1.9835622512370583 1.1393839954284035 0.9902948130640341 0.22330669840456652 0.09204285660586253 0.4912604770502284 3.7127534618436684 0.037534002590123614 0.10197161644831991 2.2022203158959844e-07 6.65713923523184 -0.1490891823643694 QLFGK(ub)STVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLFGKSTVK 9 1 O95147 O95147 DUSP14 Dual specificity protein phosphatase 14 1 9723200.0 3095900.0 3487400.0 3139900.0 True False 2997622.3491099835 4879937.006550748 2317465.995019111 1.0 1.627935889922771 0.7731013867397886 21.515387208318792 -6.709848549417174 1.7956645593405645 1.3861059942441027 0.7751159524306896 0.4643606612238488 0.2646160620180796 0.3754118353683723 2.359518546360218 0.117272619393458 0.2979912278205228 1.9505246834567885e-07 6.709848549417174 -0.6109900418134131 QLFGK(ub)STVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLFGKSTVK 9 1 O95147 O95147 DUSP14 Dual specificity protein phosphatase 14 1 12597200.0 5636400.0 3950300.0 3010500.0 True False 8550830.876035385 3245338.1011652243 2415473.355450978 1.0 0.37953482511981734 0.28248405218966494 23.027633181427465 -13.999999999999998 0.2611510309996223 5.569487282666051 0.24740175112152632 0.9995646918078278 0.006631513991334237 14.468263013999067 0.16171803532241388 34.91394555609224 0.04217347244842959 1.0000000000000041e-14 13.999999999999998 -5.322085531544524 QLFGK(ub)STVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLFGKSTVK 9 1 O95147 O95147 DUSP14 Dual specificity protein phosphatase 14 1 6235000.0 1805600.0 1936300.0 2493100.0 True False 2473179.114505288 1850747.8635121633 1904281.1270062341 1.0 0.7483274675325607 0.7699729938028159 21.237935296820325 -10.730562755381545 6.813134840159397 1.0035158792878673 0.75915023066769 0.993978809002634 0.008836749096022313 0.0004773676069916623 1.8878309431114457e-05 0.008654775168731685 0.0028520485069589824 1.859675821382928e-11 10.730562755381545 -0.2443656486201773 QLFGK(ub)STVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLFGKSTVK 9 1 O95147 O95147 DUSP14 Dual specificity protein phosphatase 14 1 12391900.0 3095900.0 7523000.0 1773000.0 True False 2574378.021624569 7482472.105801422 2143726.1025742297 1.0 2.9065164645398838 0.8327161297086529 21.29579248375307 -6.664956522797511 1.9550495980545495 2.222119286367459 0.8412116685564066 0.2570484386011962 0.8107916411754987 0.4727639396908359 3.4786245395516167 0.3344398769113109 0.899523646936208 2.162935044226071e-07 6.664956522797511 -1.3809076178110522 QLFGK(ub)STVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLFGKSTVK 9 1 O95147 O95147 DUSP14 Dual specificity protein phosphatase 14 1 11967700.0 5636400.0 4977600.0 1353700.0 True False 7296430.91005426 4700592.184337939 1107340.4901349552 1.0 0.6442317130503717 0.1517646783455557 22.798759503519914 -7.457902813766186 0.46689772407030644 1.0193889434212366 2.100263274060422e-25 0.9980973050674264 0.01517040110671887 0.11460338794775919 0.05786329162161136 0.018879367435229437 0.06547590208979868 3.484152745342551e-08 7.457902813766186 -1.0193889434212366 down QLFHGTPVTIENFLNWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLFHGTPVTIENFLNWK 17 0 E5RGS5;E5RGQ3;Q9H446-2;Q9H446 E5RGS5 RWDD1 RWD domain-containing protein 1 0 13418900.0 6363000.0 3779700.0 3276200.0 False True 6161010.047930107 5288953.920875109 2418064.936106758 1.0 0.8584556557657327 0.3924786548463992 22.554735457855703 -6.949345254890561 0.5659849680032966 1.005914052757115 0.22252042195668642 0.9991489032325374 0.007571719576312524 0.08374970441801508 0.03705852645712211 0.008059005341813974 0.03878769437718014 1.1237112921705001e-07 6.949345254890561 -0.7833936308004287 down QLFHGTPVTIENFLNWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLFHGTPVTIENFLNWK 17 0 E5RGS5;E5RGQ3;Q9H446-2;Q9H446 E5RGS5 RWDD1 RWD domain-containing protein 1 0 12421300.0 6363000.0 3475400.0 2582900.0 False True 5291116.42869509 3456677.3303871076 3122972.4480197304 1.0 0.6532982928972522 0.5902293948934945 22.33514073328998 -13.999999999999998 0.23968854326276864 3.291375365836724 0.5622610921395981 0.9995244463063397 0.003928598717748576 13.612525868763493 0.15495550193730495 14.926809705021869 0.030874512779720073 1.0000000000000041e-14 13.999999999999998 -2.729114273697126 QLFHPEQLITGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLFHPEQLITGK 12 0 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;P68363;P68363-2;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA4A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 159906000.0 13068000.0 76138000.0 70700000.0 False True 17132274.550692037 64778507.183599524 63384642.202287935 1.0 3.78108038088748 3.6997213659366435 24.030213366431024 -10.294882807062608 4.356100933949514 0.997675917563551 3.740400873445394 0.9993393712859978 0.033214678880317726 1788773.3150431856 4228968.19639076 25741.125798618526 0.011370268405563754 5.07127536510153e-11 10.294882807062608 2.742724955881843 QLFHPEQLITGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLFHPEQLITGK 12 0 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;P68363;P68363-2;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA4A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 83351000.0 32781000.0 11306000.0 39264000.0 False True 31740385.09841222 15820544.760011112 28979580.505248714 1.0 0.4984358164199627 0.9130191840898109 24.91981629636066 -10.033205855919736 7.195819848309868 1.0000000324992389 0.7057275002548876 0.40182812584562466 0.16925295110596694 8.835049619820254e-08 1.187763164512591e-08 0.16387848232627586 0.05462615507748901 9.263906094295723e-11 10.033205855919736 -0.29427253224435124 QLFHPEQLITGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLFHPEQLITGK 12 0 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;P68363;P68363-2;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA4A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 127411000.0 13068000.0 48014000.0 66329000.0 False True 17899592.749421317 45892582.718934596 50663456.288635224 1.0 2.563889768967971 2.830425082731178 24.093423427953915 -10.302331454834555 0.38525100488192404 1.728548986294405e-22 2.862895788492028 0.9991104468260693 0.02408141057591775 1.706328827972496 0.17898485705650105 1.84077714368495 0.07070113939032296 4.985038825998154e-11 10.302331454834555 2.862895788492028 QLFHPEQLITGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLFHPEQLITGK 12 0 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;P68363;P68363-2;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA4A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 48456100.0 32781000.0 9452600.0 6222500.0 False True 27258853.94453148 9401676.967605805 7523595.980410693 1.0 0.3449036040450232 0.276005586871712 24.700221571794938 -13.999999999999998 0.31816720348554595 7.644324169294059 0.2620457454183176 0.9996897855973979 0.005746550789791493 17.872320228887727 0.17980515216013088 78.96787577234191 0.02310446233925909 1.0000000000000041e-14 13.999999999999998 -7.382278423875741 QLFHPEQLITGK(ub)EDAANNYAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLFHPEQLITGKEDAANNYAR 21 1 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;P68363;P68363-2;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 961142000.0 268020000.0 416214000.0 276908000.0 True False 351376815.5093724 354116493.58946455 248256216.4490969 1.0 1.0077969802194278 0.7065241800009285 28.388443761904735 -6.9009580349434 0.9551745783480354 1.0121986788405912 0.6742760664972706 0.9870374231397769 0.0159644795777315 0.11070407036251263 0.1734621100492044 0.012512202078775795 0.03271452283693694 1.256151337365044e-07 6.9009580349434 -0.33792261234332066 QLFHPEQLITGK(ub)EDAANNYAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLFHPEQLITGKEDAANNYAR 21 1 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;P68363;P68363-2;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 735136000.0 351533000.0 334568000.0 49035000.0 True False 340373777.33443564 468162747.1490715 36191262.48153195 1.0 1.375437176199024 0.1063279984872985 28.34254465403462 -6.827458849467059 1.3391906940502596 1.2009891456794057 0.07390751209395052 0.9007034611075141 0.16773990678235054 0.18396743281979275 0.646145877383724 0.09836904324535174 0.22641610939452286 1.4877883392199117e-07 6.827458849467059 -1.1270816335854552 down QLFHPEQLITGK(ub)EDAANNYAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLFHPEQLITGKEDAANNYAR 21 1 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;P68363;P68363-2;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 5474403000.0 1257380000.0 1056670000.0 3160353000.0 True False 1907537386.7911046 868098982.6996086 2535707844.3180737 1.0 0.45508884319166143 1.3293096438773813 30.82906418743377 -6.738149604153677 1.6933665562884428 0.675082641699423 1.329627611739232 0.5966172058501422 0.228961578971565 0.32119021652474494 1.8076637314333233 0.1069941087797327 0.2630997125686907 1.8274705874073422e-07 6.738149604153677 0.654544970039809 QLFHPEQLITGK(ub)EDAANNYAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLFHPEQLITGKEDAANNYAR 21 1 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;P68363;P68363-2;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 904727000.0 268020000.0 325917000.0 310790000.0 True False 367114236.96815896 311516909.276607 237387802.92096862 1.0 0.8485557842956275 0.6466319717847338 28.451653823427627 -6.967140696024463 0.3191841269325198 1.0279195112567094 0.4607631087045703 0.9999507143614732 0.0010161946707793403 0.07724185368945873 0.012336947661869397 0.00307095111431153 0.017774551504810856 1.0785972383337068e-07 6.967140696024463 -0.5671564025521392 QLFHPEQLITGK(ub)EDAANNYAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLFHPEQLITGKEDAANNYAR 21 1 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;P68363;P68363-2;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 998807000.0 351533000.0 398339000.0 248935000.0 True False 292315265.05240774 396193068.7428996 300986157.5546057 1.0 1.3553622273946868 1.0296628111455055 28.122949929468895 -9.799246103904128 10.524272122773752 1.0000042779473401 1.19251251935653 0.3177902914079008 0.1329662299117456 0.0 0.0 0.1287439985036793 0.04291466616789309 1.5876468135910318e-10 9.799246103904128 0.19250824140918987 QLFHPEQLITGK(ub)EDAANNYAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLFHPEQLITGKEDAANNYAR 21 1 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;P68363;P68363-2;P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 1 4626620000.0 1257380000.0 785630000.0 2583610000.0 True False 1627703196.6652532 741908999.8757263 2113419490.0772507 1.0 0.45580115674387556 1.2984059344523657 30.600190509526218 -6.732345595416487 1.7148522393239458 0.6733643065033289 1.2981088088089696 0.5700726975868304 0.22872796536733953 0.3318366487632419 1.912831882519662 0.10565772469792412 0.2614716413624586 1.852057238507967e-07 6.732345595416487 0.6247445023056407 QLFLQTYAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLFLQTYAR 9 0 P53621;P53621-2;A0A3B3IS84;A0A3B3ISC6;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 8012500.0 2953600.0 2734400.0 2324500.0 False True 3872198.202703088 2326438.178607718 2083983.0381784774 1.0 0.6008055519946494 0.5381912105438454 21.88472136975137 -13.999999999999998 0.2607547753439931 3.933828242164772 0.5154709823632704 0.9995638776818595 0.0042715986482280265 14.450608405506511 0.16159435189908067 22.34977028124865 0.02726575202092082 1.0000000000000041e-14 13.999999999999998 -3.4183572598015015 QLFLQTYAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLFLQTYAR 9 0 P53621;P53621-2;A0A3B3IS84;A0A3B3ISC6;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 9115600.0 2953600.0 3025400.0 3136600.0 False True 4045625.738038779 2891727.8243400804 2395799.680304739 1.0 0.7147788776284383 0.5921950856151525 21.947931431274263 -13.999999999998316 0.11519849276159388 2.3657345964002556 0.3832591283312458 0.9997167889164823 0.0028750721471338296 11.984698346943304 0.10380547426056229 3.7732877721764915 0.185416809575588 1.0000000000038776e-14 13.999999999998316 -1.9824754680690098 QLFLYLSAEYSTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLFLYLSAEYSTK 13 0 P61009 P61009 SPCS3 Signal peptidase complex subunit 3 0 27842400.0 5400800.0 5145600.0 17296000.0 False True 8193408.451368243 4227327.477243695 13877438.018893892 1.0 0.515942480145459 1.693731992157239 22.966032306042248 -6.795134956812432 1.4759524517304035 0.7312500247643704 1.708053591234856 0.8174584320807177 0.2065165632160965 0.22779203823726193 0.9801463241764616 0.11010823842556432 0.25683790591921835 1.6027472603160585e-07 6.795134956812432 0.9768035664704856 QLGEVTEQTEGTAACIPQK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLGEVTEQTEGTAACIPQKAK 21 1 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 105996000.0 10081000.0 25351000.0 70564000.0 True False 15293614.01981989 20826915.981732957 56616994.47070014 1.0 1.3618047346259778 3.702002312685992 23.866426033132228 -6.934267433692976 0.7108991876094984 0.969418887445064 4.239165349323064 0.9973123531940662 0.06208667785457847 0.09048197231328714 0.06726566138013472 0.05807517929802821 0.2070048403678798 1.1634093942698723e-07 6.934267433692976 3.2697464618779994 up QLGEVTEQTEGTAACIPQK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLGEVTEQTEGTAACIPQKAK 21 1 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 86950000.0 10081000.0 19288000.0 57581000.0 True False 13050053.226218347 18214605.84448535 47101848.83095289 1.0 1.395749544368992 3.6093223540515855 23.637552355224678 -6.937337690849021 0.683880150346997 0.9736400550320756 4.162236734508928 0.9977940244675443 0.05392802596087302 0.08900241336683101 0.060299063418568534 0.05149089876687613 0.19285855522874165 1.1552136427467369e-07 6.937337690849021 3.188596679476853 up QLGGLYINFNADK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLGGLYINFNADK 13 0 Q5QJE6 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 0 37314000.0 10214000.0 12975000.0 14125000.0 False True 15495384.743422294 10659509.875862287 11333187.55879257 1.0 0.6879151471464554 0.7313911688190541 23.8853352410483 -10.331863375191206 5.4289867311639775 1.000068487256291 0.7096531579830142 0.9834619518661553 0.017749011524034238 1.4716650102572738e-05 1.8111704917563449e-06 0.017189447470075555 0.00572846883701525 4.6573258540886547e-11 10.331863375191206 -0.29041532927327685 QLGGLYINFNADK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLGGLYINFNADK 13 0 Q5QJE6 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 0 28637500.0 10214000.0 10211000.0 8212500.0 False True 13222224.348040275 9642748.87380962 6717909.267365972 1.0 0.7292834110199329 0.508077089794779 23.65646156314075 -6.9894647566827235 0.15680395151019025 1.2350418525567608 6.1582011204289565e-09 0.9999983072391307 0.00026166492786129165 0.07357684937775448 0.004780077528362005 0.010520143043565872 0.02646483735044608 1.0245549203237685e-07 6.9894647566827235 -1.2350418463985597 QLGGSVELVDIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLGGSVELVDIGK 13 0 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;A0A087WYZ1;J3KSV5;J3QRD0;J3QKQ0;J3QLU1;J3QR27;J3QL02;J3QQN6;A0A087WVS2;J3KRD5 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 49650000.0 13678000.0 18647000.0 17325000.0 False True 17931990.457940407 15864940.28543671 15532375.193134934 1.0 0.8847283475110042 0.8661824368893244 24.096032301018948 -13.999999999999995 0.2571356152302224 1.8313921231337624 0.8592157265411458 0.9995565362883899 0.001246592896396614 14.292275087033524 0.16045868132110844 6.163766740724493 0.008232174422875476 1.0000000000000123e-14 13.999999999999995 -0.9721763965926167 QLGGSVELVDIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLGGSVELVDIGK 13 0 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;A0A087WYZ1;J3KSV5;J3QRD0;J3QKQ0;J3QLU1;J3QR27;J3QL02;J3QQN6;A0A087WVS2;J3KRD5 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 45945600.0 20796000.0 7761600.0 17388000.0 False True 20135842.363154884 10860847.356209297 12833561.171181353 1.0 0.5393788429771765 0.637349108109058 24.263262491485317 -10.773463083147242 8.094583563229587 1.0060365853100597 0.588363975543242 0.9592475442200095 0.03999619325638201 0.00436582802189869 0.00012218290688235069 0.038802920928189856 0.012908715866138407 1.6847556319834447e-11 10.773463083147242 -0.41767260976681764 QLGGSVELVDIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLGGSVELVDIGK 13 0 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;A0A087WYZ1;J3KSV5;J3QRD0;J3QKQ0;J3QLU1;J3QR27;J3QL02;J3QQN6;A0A087WVS2;J3KRD5 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 50367000.0 13678000.0 21535000.0 15154000.0 False True 18735126.23405145 20583512.493278146 11574937.306426708 1.0 1.0986588633636862 0.6178200862820469 24.15924236254184 -6.853232223634134 1.219380622447589 1.0528310534525551 0.5973640393828056 0.9448809695365685 0.04868392265503355 0.15393546881248674 0.4388277235840899 0.031213412075133725 0.072395520000125 1.4020637999937106e-07 6.853232223634134 -0.45546701406974954 QLGGSVELVDIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLGGSVELVDIGK 13 0 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;A0A087WYZ1;J3KSV5;J3QRD0;J3QKQ0;J3QLU1;J3QR27;J3QL02;J3QQN6;A0A087WVS2;J3KRD5 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 32545000.0 20796000.0 0.0 11749000.0 False True 17292795.419007245 0.0 14205661.578761786 1.0 0.0 0.8214786120205725 24.043667766919594 -9.572854462405438 10.848882362271373 1.000000273853322 0.41073930601028624 0.4069007752861996 0.335367239010063 0.0 0.0 0.3247179328873672 0.10823931096245572 2.6739023171533357e-10 9.572854462405438 -0.5892609678430358 QLGGSVELVDIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLGGSVELVDIGK 13 0 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;A0A087WYZ1;J3KSV5;J3QRD0;J3QKQ0;J3QLU1;J3QR27;J3QL02;J3QQN6;A0A087WVS2;J3KRD5 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 12268000.0 12268000.0 0.0 0.0 False True 15881167.83843334 0.0 0.0 1.0 0.0 0.0 23.920813670695352 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 QLGGSVELVDIGKQK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLGGSVELVDIGKQK 15 1 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;A0A087WYZ1;J3KSV5;J3QRD0;J3QKQ0;J3QLU1;J3QR27;J3QL02;J3QQN6;A0A087WVS2;J3KRD5 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 1 32967600.0 3638800.0 5452800.0 23876000.0 True False 5520325.631913552 4479705.237079144 19156898.134777464 1.0 0.811492932804819 3.4702478462555777 22.396321940257092 -6.889875141086755 1.0230960492470713 0.8567144912658657 3.6983882066046965 0.9808191435688642 0.16776789801578698 0.11924550842311396 0.22242757905766894 0.12496247403753415 0.3114012598766771 1.2886199744590233e-07 6.889875141086755 2.841673715338831 up QLGGSVELVDIGKQK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLGGSVELVDIGKQK 15 1 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;A0A087WYZ1;J3KSV5;J3QRD0;J3QKQ0;J3QLU1;J3QR27;J3QL02;J3QQN6;A0A087WVS2;J3KRD5 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 1 32597300.0 3638800.0 4799500.0 24159000.0 True False 4710498.331471405 4532403.605900421 19762309.892273314 1.0 0.9621919565534899 4.195375627295938 22.16744826234954 -6.904254402355333 0.9339734695938986 0.8808125874260665 4.565674612579724 0.9885668129870534 0.16202558076034887 0.10834128008202583 0.1602822241177166 0.12899401751157835 0.34338558744388326 1.2466530320701734e-07 6.904254402355333 3.6848620251536577 up QLGISATMLNASSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLGISATMLNASSSK 15 0 P46063;F8WA66;F8WD97 P46063 RECQL ATP-dependent DNA helicase Q1 0 15501200.0 4978400.0 5168600.0 5354200.0 False True 6526730.610894177 4397465.027045 4800198.745113021 1.0 0.6737622998726062 0.7354675765383524 22.63792906299297 -10.715189142361137 6.818141322947413 1.0033768195252797 0.7046149382054823 0.9683085151240621 0.025191073711390587 0.0013041907938165453 5.447924704386336e-05 0.02460090399142129 0.008130384079774936 1.9266856272907014e-11 10.715189142361137 -0.2987618813197974 QLGISATMLNASSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLGISATMLNASSSK 15 0 P46063;F8WA66;F8WD97 P46063 RECQL ATP-dependent DNA helicase Q1 0 6699200.0 2421800.0 0.0 4277400.0 False True 2344921.284626297 0.0 3157020.620750585 1.0 0.0 1.3463226426612054 21.16110806384081 -6.707781128951279 1.8029130626386516 0.3838390251624367 1.342984809529352 0.45463688915378964 0.42154351667023315 0.37955909745895505 2.40354539187053 0.18615556945351389 0.47423515303787395 1.9598321197169345e-07 6.707781128951279 0.9591457843669153 QLGISATMLNASSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLGISATMLNASSSK 15 0 P46063;F8WA66;F8WD97 P46063 RECQL ATP-dependent DNA helicase Q1 0 13140000.0 4978400.0 3621500.0 4540100.0 False True 6819049.0162013285 3461490.155300991 3467821.8862945675 1.0 0.5076206589917248 0.5085491947712056 22.701139124515862 -10.005097984676905 6.965440827930041 1.000000057804149 0.5080849268814648 0.9999973271298548 0.0003790731446097514 3.4001487019733017e-10 4.868239722647325e-11 0.00036703603776983864 0.00012234533133868568 9.883300843876093e-11 10.005097984676905 -0.49191513092268424 QLGLVVCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLGLVVCR 8 0 Q9UK45;A0A087X2I5 Q9UK45 LSM7 U6 snRNA-associated Sm-like protein LSm7 0 40022000.0 18945000.0 21077000.0 0.0 False True 24837078.463640947 17932393.757502526 0.0 1.0 0.7220009303330017 0.0 24.56599214638903 -7.385772693282516 0.7685348597876295 0.9900817709099793 4.434138961369954e-18 0.987554093100606 0.04701729999114239 0.11201002664170645 0.1386328714853013 0.04061365544899332 0.07263123670173739 4.11364970339911e-08 7.385772693282516 -0.9900817709099793 down QLGPQVQQIILVSPMGVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLGPQVQQIILVSPMGVSR 19 0 O60763;O60763-2 O60763 USO1 General vesicular transport factor p115 0 3517900.0 0.0 2032000.0 1485900.0 False True 0.0 1728833.5206739623 1332153.321759259 0.0 QLGPQVQQIILVSPMGVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLGPQVQQIILVSPMGVSR 19 0 O60763;O60763-2 O60763 USO1 General vesicular transport factor p115 0 3469200.0 0.0 1244200.0 2225000.0 False True 0.0 1189227.1299808065 1699500.8253134112 0.0 QLGSILK(ub)TNVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLGSILKTNVR 11 1 O14980 O14980 XPO1 Exportin-1 1 3096390.0 752970.0 1407100.0 936320.0 True False 987150.9617718523 1197166.1648328416 839438.5882156473 1.0 1.2127488207923434 0.8503649600957954 19.912911202629804 -6.747584139748901 1.6586578250011852 1.1254593118613887 0.8497695629634345 0.6385715487946335 0.08938999582568267 0.3042735302921246 1.6462057111372845 0.04258594710444168 0.10365595612837064 1.7881990517720952e-07 6.747584139748901 -0.27568974889795417 QLGSILK(ub)TNVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLGSILKTNVR 11 1 O14980 O14980 XPO1 Exportin-1 1 4549720.0 634120.0 1136100.0 2779500.0 True False 613990.2076997387 1589750.6546832332 2051465.5667873546 1.0 2.5892117410782443 3.3412024183137925 19.22785612121194 -9.191228972972235 0.24843710645471628 2.7231302753128517e-21 3.8426720825928626 0.999136347681253 0.02868119291019476 0.6213515650689666 0.09023064807673159 0.8474074122463543 0.3238279094301344 6.43829729827232e-10 9.191228972972235 3.8426720825928626 QLGSILK(ub)TNVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLGSILKTNVR 11 1 O14980 O14980 XPO1 Exportin-1 1 3973170.0 752970.0 1804300.0 1415900.0 True False 1031363.3572491395 1724580.0599777906 1081493.5813758476 1.0 1.6721362532964175 1.04860578357216 19.976121264152695 -10.339616412164908 5.094004527366737 0.9998441334686087 1.3603710184343398 0.3081366783545557 0.25455524831723536 0.00045079826628867755 5.844103751648748e-05 0.2465778266162116 0.08215735311850338 4.5749208819129404e-11 10.339616412164908 0.36052688496573115 QLGTESNQVLIK(ub)TLGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLGTESNQVLIKTLGTK 17 1 Q5XUX1;Q5XUX1-2 Q5XUX1 FBXW9 F-box/WD repeat-containing protein 9 1 14403800.0 1410500.0 2866300.0 10127000.0 True False 1365724.4495686647 4010828.5375570417 7474434.896512157 1.0 2.936777282433347 5.472871851179644 20.381235002189563 -6.96741667054077 0.3138216944356601 0.6265138555128481 7.864198690443664 0.9999546452354338 0.012334395246228286 0.07715019469159096 0.012016388415248462 0.03945230419592282 0.22433863965228337 1.0779120562576513e-07 6.96741667054077 7.237684834930816 QLGTESNQVLIK(ub)TLGTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLGTESNQVLIKTLGTK 17 1 Q5XUX1;Q5XUX1-2 Q5XUX1 FBXW9 F-box/WD repeat-containing protein 9 1 9351800.0 1410500.0 2974000.0 4967300.0 True False 1172893.2457448407 2957978.47170722 6005939.4637997635 1.0 2.521950298919804 5.1206190210309535 20.16164027762384 -6.963015833196379 0.39061858345912737 0.8414950492797999 6.894538615152728 0.9998662108702335 0.019678135344717514 0.07864096401875487 0.01727588224234661 0.0335403343519061 0.21853798619220927 1.0888903946256476e-07 6.963015833196379 6.053043565872928 QLHEAIVTLGLAEPSTNISFPLVTVHLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLHEAIVTLGLAEPSTNISFPLVTVHLEK 29 0 P42704 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 147074000.0 29135000.0 55021000.0 62918000.0 False True 44199925.05380934 45202072.668964855 50482229.72206091 1.0 1.0226730614121065 1.1421338307837274 25.397540587570568 -6.938643292099982 0.6720604435001887 0.9986224641981212 1.173102942227179 0.9979808287660615 0.0028016737446828486 0.08839087997310004 0.05746794274776758 0.0026999751760993884 0.010344706811192326 1.151745987461884e-07 6.938643292099982 0.17448047802905786 QLHEAIVTLGLAEPSTNISFPLVTVHLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLHEAIVTLGLAEPSTNISFPLVTVHLEK 29 0 P42704 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 70191000.0 29135000.0 12983000.0 28073000.0 False True 37715831.83670976 12260484.63702577 22964002.05330475 1.0 0.325075281120867 0.6088690328434786 25.168666909663017 -10.422272883703142 6.039478797437845 1.000172814120587 0.46697215698238603 0.8246729644026117 0.11585831398508269 0.0002696783421303102 2.5796755359464022e-05 0.11221504714870967 0.03739311004865786 3.782048695709082e-11 10.422272883703142 -0.533200657138201 QLHLCYNIVK(ub)DR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLHLCYNIVKDR 12 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 3590690.0 824780.0 2048500.0 717410.0 True False 1081294.567180881 1742871.784990458 643179.2950826506 1.0 1.611838103963124 0.5948233854161762 20.04432816614362 -6.743783115708179 1.672670382664682 1.3624319752155951 0.5936993872069499 0.6218856724189372 0.2570582837602772 0.3110091133742624 1.709886585054105 0.1215039361067215 0.29695083246958875 1.8039183829390726e-07 6.743783115708179 -0.7687325880086452 QLHLCYNIVK(ub)DR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLHLCYNIVKDR 12 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 13893700.0 8087500.0 3017900.0 2788300.0 True False 12269328.775448184 2479332.166039679 2237191.282844695 1.0 0.20207561566049176 0.1823401527328436 23.548552989103115 QLHLNQLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLHLNQLIR 9 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 20178300.0 6256900.0 5297300.0 8624100.0 False True 8202856.491905801 4506963.48871367 7731760.860208646 1.0 0.5494382954475593 0.942569319338695 22.967694958211563 -10.206788149510798 7.852930042352955 1.0000001498959974 0.7460038073931272 0.35756114203356504 0.16049506843186426 4.2107244079655503e-07 4.2756704087309875e-08 0.1553987721043584 0.051799560598752514 6.211719703715304e-11 10.206788149510798 -0.2539963425028702 QLHLNQLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLHLNQLIR 9 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 15999300.0 4158300.0 0.0 11841000.0 False True 4026297.042638343 0.0 8739486.877614355 1.0 0.0 2.1706016185749584 21.941022181258763 -6.781426255359466 1.5302616159275495 0.4348294164441435 2.1885938526827386 0.7724424722387675 0.4231523688571717 0.24835130442773884 1.1487781167554376 0.2177735668247543 0.5132561544597782 1.6541456403304726e-07 6.781426255359466 1.7537644362385951 QLHLNQLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLHLNQLIR 9 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 22127100.0 6256900.0 11510000.0 4360200.0 False True 8570245.016364727 11001450.141519906 3330410.561137769 1.0 1.2836797688412451 0.38860155745587327 23.030905019734455 -6.821478929816437 1.36550489209406 1.1526754748352197 0.36844057641543093 0.8877449633795328 0.12513560606514942 0.19156477912175776 0.7014636062910812 0.07200689495626801 0.16589901001651686 1.508415790900719e-07 6.821478929816437 -0.7842348984197888 down QLHLNQLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLHLNQLIR 9 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 11256800.0 3650800.0 4199800.0 3406200.0 False True 4726032.568026776 3966077.4380790917 2786306.5505634053 1.0 0.8391980759741182 0.5895656685511903 22.172198140567552 -6.964680092516019 0.3635017361538409 1.0206683919943715 0.399493988620898 0.9999063961748775 0.0016337157331061203 0.07806969112240206 0.0152437983295807 0.003326539748024947 0.021277943224959135 1.0847256441237532e-07 6.964680092516019 -0.6211744033734735 QLIAQVMLYSQGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLIAQVMLYSQGFR 14 0 Q14204;A0A2R8YFZ7 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 14144900.0 4608500.0 4339600.0 5196800.0 False True 5965794.097116081 4098097.445185019 4251035.7236709315 1.0 0.6869324315376685 0.7125682942570748 22.508282754808942 -10.027453937414723 6.039584905953541 1.0000004015206818 0.699750362897352 0.9945621874660866 0.010465797129833618 5.65832041402512e-08 9.113173968120981e-09 0.010133478011351253 0.003377821499042363 9.387415971630617e-11 10.027453937414723 -0.3002500386233298 QLIVGVNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLIVGVNK 8 0 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 1113810000.0 344760000.0 288500000.0 480550000.0 False True 451983698.66058916 245456924.5641923 430827295.76109636 1.0 0.5430658789057672 0.9531921107726058 28.751695500134 -10.336501571903753 8.389017992339715 1.0000006840343705 0.7481289948391865 0.33460863877769376 0.16743333303402277 2.142181704856953e-06 1.693231082344974e-07 0.1621170672447987 0.054038875870064174 4.607851009022375e-11 10.336501571903753 -0.251871689195184 QLIVGVNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLIVGVNK 8 0 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 541899000.0 164440000.0 75579000.0 301880000.0 False True 159219942.2099052 105758088.83927834 222808571.79412365 1.0 0.664226398850552 1.3993760373332338 27.24644580305529 -6.782516391075058 1.526019290762177 0.8104986607816519 1.405670763597812 0.7762110188563296 0.14215449108380251 0.2466827387018127 1.1347970823278697 0.07335752705982522 0.1727358936331176 1.64999872614873e-07 6.782516391075058 0.5951721028161602 QLIVGVNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLIVGVNK 8 0 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 1393310000.0 215850000.0 905450000.0 272010000.0 False True 327460230.7487473 743865373.186861 218247104.2737819 1.0 2.27162050025431 0.6664843049024719 28.286744464572063 -6.695543644306255 1.8464911297498792 1.7930259759512128 0.6715918201749667 0.3966184472991837 0.5372134676639899 0.40484565942436723 2.6802595829496996 0.23237053508016572 0.6009652271862417 2.0158413790517888e-07 6.695543644306255 -1.1214341557762462 QLIVGVNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLIVGVNK 8 0 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 922990000.0 344760000.0 237150000.0 341080000.0 False True 472227088.78868127 226671928.8498219 260523928.7631004 1.0 0.4800061966611496 0.5516920459420812 28.814905561656893 -10.5752354577467 6.40575731247165 1.000920538913146 0.5158491213017614 0.9838235245118673 0.029265625419390484 0.00038540457243112995 2.555613960043737e-05 0.028384946737901158 0.00944543998880365 2.6592829080906255e-11 10.5752354577467 -0.4850714176113845 QLIVGVNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLIVGVNK 8 0 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 366297000.0 164440000.0 114430000.0 87427000.0 False True 136739145.92717594 113813542.87742326 105707581.48322463 1.0 0.8323406008257334 0.7730601267578635 27.026851078489567 -13.99999999773701 0.1448601169775394 1.8049793486175654 0.7038220409409999 0.9995842854714567 0.0019594840860147214 11.94211439851652 0.11957811895133157 2.710872834631336 0.06212215859665991 1.0000000052107265e-14 13.99999999773701 -1.1011573076765655 QLIVGVNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLIVGVNK 8 0 P68104;Q5VTE0;A0A087WV01;A0A2U3TZH3;Q05639;A0A2R8Y488 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 866480000.0 215850000.0 421950000.0 228680000.0 False True 279422080.0396021 398468111.5761397 187062586.4549469 1.0 1.4260437525898646 0.6694624362843293 28.057870786664513 -6.753919444578265 1.635395169745334 1.249331305548743 0.6675018830949702 0.6656555524709796 0.17907188495048235 0.29324967957338927 1.5442450000404617 0.08645782780007942 0.20903526191654118 1.762302898107546e-07 6.753919444578265 -0.5818294224537728 QLIVGVNK(ub)MDSTEPPYSQK ddPTM_RPMI8226_Bortezomib_1h_R1 2 QLIVGVNKMDSTEPPYSQK 19 1 P68104;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 148093100.0 40483400.0 58426600.0 49183100.0 True False 53074129.44180329 49709579.02510304 44094104.6096089 1.0 0.9366065830549413 0.8308022208439397 25.661505466464778 -6.963423889804724 0.38416825573363245 1.0069355959887503 0.7567069702602179 0.9998768324490062 0.0007745615549588336 0.07850025093784233 0.01677338445332684 0.0013716113993468087 0.008922931915244852 1.0878677699717565e-07 6.963423889804724 -0.25022862572853233 QLIVGVNK(ub)MDSTEPPYSQK ddPTM_RPMI8226_Bortezomib_2h_R1 2 QLIVGVNKMDSTEPPYSQK 19 1 P68104;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 173474800.0 59354000.0 56445100.0 57675700.0 True False 57469839.75873695 78983922.78730798 42568703.936088376 1.0 1.3743543242662393 0.7407138094484906 25.77630169077136 -6.7466228958475325 1.6622687226358315 1.221016447146901 0.7397672772626923 0.634316090761893 0.15728751125930138 0.3059866040227238 1.6623844357381137 0.07478062786124899 0.18220083552388272 1.7921613381099158e-07 6.7466228958475325 -0.4812491698842086 QLIVGVNK(ub)MDSTEPPYSQK ddPTM_RPMI8226_Bortezomib_8h_R1 2 QLIVGVNKMDSTEPPYSQK 19 1 P68104;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 685886600.0 150535600.0 109493000.0 425858000.0 True False 228373510.82650512 89953118.67728639 341686979.6398081 1.0 0.3938859561765181 1.496176060013313 27.766820080484905 -6.757452602342606 1.6223309411595945 0.6468110556537321 1.4996631455852012 0.6803452271788005 0.2548470999494523 0.2872346615393461 1.4894255630956765 0.1239850025329062 0.2986775543389881 1.7480240263500804e-07 6.757452602342606 0.8528520899314691 QLIVGVNK(ub)MDSTEPPYSQK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QLIVGVNKMDSTEPPYSQK 19 1 P68104;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 182086200.0 40483400.0 65465900.0 76136900.0 True False 55451207.002748884 62573400.07121883 58154932.30867624 1.0 1.128440722094956 1.0487586375855322 25.72471552798767 -10.856791345027817 7.875245122654668 0.9933987088014365 1.088599679840244 0.6224238405637669 0.03253007478156929 0.003995068247789481 7.264885772404092e-05 0.03337451746473128 0.01049903648999166 1.3906205886026919e-11 10.856791345027817 0.09520097103880742 QLIVGVNK(ub)MDSTEPPYSQK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 QLIVGVNKMDSTEPPYSQK 19 1 P68104;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 170268200.0 59354000.0 77143800.0 33770400.0 True False 49355480.82803207 76728211.03755455 40831634.50331232 1.0 1.5546036579989266 0.8272968638595752 25.556706966205635 -6.702925512229 1.8209155885746642 1.3434036655995576 0.8293713365053771 0.43127995868596103 0.23398279039330902 0.38945344663163284 2.5126080269405264 0.1024457734042938 0.2624694469092335 1.9818669154328224e-07 6.702925512229 -0.5140323290941805 QLIVGVNK(ub)MDSTEPPYSQK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 QLIVGVNKMDSTEPPYSQK 19 1 P68104;Q5VTE0;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 506492300.0 150535600.0 90490700.0 265466000.0 True False 194871301.70029894 85454812.99728172 217153911.91118112 1.0 0.43851922911002256 1.1143452628296782 27.537946402577354 -6.686162154556065 1.8799450977662178 0.6467257131139488 1.1119123503826909 0.3525182951058222 0.2376558099492711 0.425001978556058 2.909059174930007 0.10124342409067658 0.2649379462511724 2.0598606698863494e-07 6.686162154556065 0.4651866372687421 QLK(ub)ELDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLKELDLR 8 1 Q5VWM4;Q5VXH5;O95522 Q5VWM4 PRAMEF8;PRAMEF7;PRAMEF12 PRAME family member 8;PRAME family member 7;PRAME family member 12 1 27191400.0 4168600.0 4640800.0 18382000.0 True False 5465074.968779827 3948410.7296967134 16480006.972594863 1.0 0.7224806159572711 3.0155134315155263 22.381809855952376 -6.8766458576061975 1.0982949840386027 0.8345517630563916 3.1679431427713935 0.9708795315769946 0.17437319329825804 0.13064458026090858 0.2905707030400235 0.12264519286361195 0.29422844548363974 1.3284773136878925e-07 6.8766458576061975 2.333391379715002 up QLK(ub)ELDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLKELDLR 8 1 Q5VWM4;Q5VXH5;O95522 Q5VWM4 PRAMEF8;PRAMEF7;PRAMEF12 PRAME family member 8;PRAME family member 7;PRAME family member 12 1 30336500.0 2462200.0 3396300.0 24478000.0 True False 2384038.808740138 4752460.301470522 18066477.475740574 1.0 1.993449219051091 7.578097055092795 21.184976290326105 -6.937229395781313 0.6848528589948293 0.9333026400690382 8.968798511766012 0.9977780338003994 0.1364794574325097 0.08905364303924448 0.060537723942608396 0.13021339844748994 0.4868163706149692 1.1555017411316827e-07 6.937229395781313 8.035495871696973 QLK(ub)ELDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLKELDLR 8 1 Q5VWM4;Q5VXH5;O95522 Q5VWM4 PRAMEF8;PRAMEF7;PRAMEF12 PRAME family member 8;PRAME family member 7;PRAME family member 12 1 60008300.0 5008300.0 13803000.0 41197000.0 True False 7597957.255774611 11339746.806668773 33054394.892713446 1.0 1.4924730983515764 4.350431804231512 22.857180165105017 -6.936545747470503 0.6909626358604531 0.9652098888256672 5.048620898883401 0.9976753680943944 0.07121651291834057 0.08937877510500397 0.062057049062175705 0.06762750845624205 0.24995142483445318 1.157322116318021e-07 6.936545747470503 4.083411010057734 up QLK(ub)ELDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLKELDLR 8 1 Q5VWM4;Q5VXH5;O95522 Q5VWM4 PRAMEF8;PRAMEF7;PRAMEF12 PRAME family member 8;PRAME family member 7;PRAME family member 12 1 35285700.0 4168600.0 5118100.0 25999000.0 True False 5709844.072179191 4891965.41870661 19858571.66621278 1.0 0.856759896919491 3.477953410842208 22.445019917475268 -6.893981795669463 0.9985543806217572 0.8723071230778967 3.721783042855581 0.9833261002845907 0.15537935458961435 0.11597098746559839 0.20346313802909693 0.1179011172422856 0.2984641951934815 1.2764923144439687e-07 6.893981795669463 2.849475919777684 up QLK(ub)ELDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLKELDLR 8 1 Q5VWM4;Q5VXH5;O95522 Q5VWM4 PRAMEF8;PRAMEF7;PRAMEF12 PRAME family member 8;PRAME family member 7;PRAME family member 12 1 33236600.0 2462200.0 7450400.0 23324000.0 True False 2047428.3939545874 7410263.216411394 28200940.562008638 1.0 3.6193027498747075 13.773834848279506 20.96538156576038 -6.945593844318967 0.6052892637780799 0.8868238700469897 17.030870086957336 0.9988085573784241 0.1901572261326248 0.08530479028807636 0.04366727757325235 0.19416239120980552 0.8548634735287473 1.1334598884942687e-07 6.945593844318967 16.144046216910347 QLK(ub)ELDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLKELDLR 8 1 Q5VWM4;Q5VXH5;O95522 Q5VWM4 PRAMEF8;PRAMEF7;PRAMEF12 PRAME family member 8;PRAME family member 7;PRAME family member 12 1 44542300.0 5008300.0 10782000.0 28752000.0 True False 6483343.0783522725 10181972.221860284 23519431.020433065 1.0 1.5704817867586933 3.627670283092666 22.628306487197467 -6.947258696084771 0.5881697375119512 0.9760892293010021 4.325252797534827 0.9989682253329046 0.03624964368335585 0.08460554989211368 0.04066452878802174 0.03765258366958752 0.1722475014156776 1.129123129823235e-07 6.947258696084771 3.349163568233825 QLK(ub)EQQMVMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLKEQQMVMR 10 1 B4DR61;P61619;Q8TC24;Q9H9S3-2;Q9H9S3-3;Q9H9S3;F8W776;P61619-3;H7C1S8 B4DR61 SEC61A1;SEC61A2 Protein transport protein Sec61 subunit alpha isoform 1;Protein transport protein Sec61 subunit alpha isoform 2 1 44271400.0 1738100.0 0.0 42533300.0 True False 2278665.9317843425 0.0 38132362.12422315 1.0 0.0 16.73451188799889 21.119758000340042 -6.892703430775172 1.0062800810302013 0.15824371624071426 18.25229660353024 0.9825721952377268 1.0117457087001254 0.11697580632422919 0.2092667115467598 0.7632581437665915 1.9222493573191242 1.2802552611546183e-07 6.892703430775172 18.094052887289525 up QLK(ub)EQQMVMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLKEQQMVMR 10 1 B4DR61;P61619;Q8TC24;Q9H9S3-2;Q9H9S3-3;Q9H9S3;F8W776;P61619-3;H7C1S8 B4DR61 SEC61A1;SEC61A2 Protein transport protein Sec61 subunit alpha isoform 1;Protein transport protein Sec61 subunit alpha isoform 2 1 109842800.0 0.0 3971700.0 105871100.0 True False 0.0 5557620.522141881 78140282.84508047 0.0 QLK(ub)EQQMVMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLKEQQMVMR 10 1 B4DR61;P61619;Q8TC24;Q9H9S3-2;Q9H9S3-3;Q9H9S3;F8W776;P61619-3;H7C1S8 B4DR61 SEC61A1;SEC61A2 Protein transport protein Sec61 subunit alpha isoform 1;Protein transport protein Sec61 subunit alpha isoform 2 1 62288000.0 1738100.0 1842000.0 58707900.0 True False 2380722.5403863755 1760614.3493205619 44842303.14715387 1.0 0.7395294157356219 18.835585578097756 21.182968061862933 -6.903633788435653 0.9379925234803442 0.3208054423993141 20.881828167438943 0.9882896817948957 0.9165568052005105 0.10877979264418035 0.1627110485707517 0.7275397401813767 1.9299276226496063 1.2484357931421845e-07 6.903633788435653 20.561022725039628 up QLK(ub)EQQMVMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLKEQQMVMR 10 1 B4DR61;P61619;Q8TC24;Q9H9S3-2;Q9H9S3-3;Q9H9S3;F8W776;P61619-3;H7C1S8 B4DR61 SEC61A1;SEC61A2 Protein transport protein Sec61 subunit alpha isoform 1;Protein transport protein Sec61 subunit alpha isoform 2 1 66304600.0 0.0 6618900.0 59685700.0 True False 0.0 6583242.67195121 72165703.91450362 0.0 QLK(ub)LDPSIFESLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLKLDPSIFESLQK 14 1 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 1 12573100.0 5078100.0 4897500.0 2597500.0 True False 4916898.495111406 6853097.290125096 1917136.8266703235 1.0 1.3937845771961213 0.38990774948403434 22.22931714166575 -6.800289920332009 1.4546175223532807 1.217187085987465 0.3759314655939868 0.8330511762354149 0.16874516610013393 0.22033617149625653 0.9203702273290915 0.09125874177544524 0.21220734613256875 1.5838355243513532e-07 6.800289920332009 -0.8412556203934781 down QLK(ub)LDPSIFESLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLKLDPSIFESLQK 14 1 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 1 12922800.0 5078100.0 5309100.0 2535600.0 True False 4222665.147973682 5280498.824526158 3065782.236710218 1.0 1.2505132752617374 0.726030156139988 22.009722417100026 -6.776795192430522 1.5480925451587575 1.1424358545259197 0.7222659201135332 0.7559822489727019 0.10580625129023857 0.2555822876078075 1.2095721606159453 0.053840730535530325 0.12740006124048348 1.6718788645299032e-07 6.776795192430522 -0.4201699344123865 QLK(ub)LDPSIFESLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLKLDPSIFESLQK 14 1 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 1 15482600.0 4799400.0 2822900.0 7860300.0 True False 6212917.910317658 2665803.133471467 6429806.0534887975 1.0 0.42907425656540954 1.0349092240235394 22.56683956177211 -11.766778442990232 17.540769917913682 0.915982957532471 0.7587925662648938 0.0 0.2846843857865309 0.0 0.0 0.0 0.08253704641464031 1.7108879085770659e-12 11.766778442990232 -0.15719039126757728 QLKPWCWYCNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLKPWCWYCNR 11 1 J3QRS9;O43670-2;O43670;O43670-4;O43670-3 J3QRS9 ZNF207 BUB3-interacting and GLEBS motif-containing protein ZNF207 0 37764900.0 9494900.0 14359000.0 13911000.0 False True 12447905.848742405 12216693.17094363 12471623.163734492 1.0 0.9814255762689487 1.0019053257054062 23.56939971768924 -9.922940790695005 4.260578576065887 1.0000002146985887 0.9916654509868302 0.18088355816822166 0.008360822718388209 388575465664.20386 98370938079.4183 871166.997832773 0.0030719213834554367 1.1941508972882647e-10 9.922940790695005 -0.008334763711758453 QLKPWCWYCNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLKPWCWYCNR 11 1 J3QRS9;O43670-2;O43670;O43670-4;O43670-3 J3QRS9 ZNF207 BUB3-interacting and GLEBS motif-containing protein ZNF207 0 19873400.0 8085800.0 5526200.0 6261400.0 False True 12266749.751161532 4540006.433602326 5023831.545530886 1.0 0.37010671332660344 0.4095487107377553 23.54824970139083 -9.950808254681643 5.9413700977796715 1.0000003563001598 0.38982771203199945 0.9968759693380922 0.01610212801622245 7.599450045184332e-08 1.3451210504347283e-08 0.015590827471202565 0.005196939470350548 1.1199322355108677e-10 9.950808254681643 -0.6101726442681603 QLKPWCWYCNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLKPWCWYCNR 11 1 J3QRS9;O43670-2;O43670;O43670-4;O43670-3 J3QRS9 ZNF207 BUB3-interacting and GLEBS motif-containing protein ZNF207 0 30296100.0 9494900.0 11684000.0 9117200.0 False True 13005421.120024519 11167762.24617885 6963905.134628068 1.0 0.8587005482647375 0.5354617178759175 23.63260977921213 -6.9573347576445705 0.4714963320770441 1.0084146554397704 0.3724629419125701 0.9996582218595641 0.003594562224286886 0.08066728346232585 0.02475596484275907 0.004481965754048804 0.026675931243367715 1.1032279152181008e-07 6.9573347576445705 -0.6359517135272003 QLKPWCWYCNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLKPWCWYCNR 11 1 J3QRS9;O43670-2;O43670;O43670-4;O43670-3 J3QRS9 ZNF207 BUB3-interacting and GLEBS motif-containing protein ZNF207 0 30428000.0 8085800.0 9175200.0 13167000.0 False True 10467227.494946541 8664592.054350985 10770741.104828944 1.0 0.8277829118106158 1.0289965618908097 23.31937602348328 -6.6800969416270535 1.9014838789390094 0.8910458257035387 1.0282322414874545 0.32458383541550095 0.07298812826443005 0.43831377221827167 3.064096680818159 0.030799004327895358 0.0812219715217475 2.088829817853647e-07 6.6800969416270535 0.13718641578391577 QLLCGAAIGTHEDDKYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLLCGAAIGTHEDDKYR 17 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 34272200.0 6331200.0 14303000.0 13638000.0 False True 8300264.5114280125 12169048.152657343 12226870.58493356 1.0 1.466103656805478 1.4730699929019488 22.984725882078298 -11.49074309122965 0.6644908597876319 3.783380477368728e-07 1.4719658682413748 0.9999769041020985 0.0010639139826250628 4.909320242357822 0.33648186279966275 7.1342876659707555 0.00112474341413692 3.2304045163039377e-12 11.49074309122965 1.471965489903327 QLLCGAAIGTHEDDKYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLLCGAAIGTHEDDKYR 17 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 12766900.0 6238000.0 1482900.0 5046000.0 False True 6039978.104508564 2075029.7032213395 3724301.2232448324 1.0 0.3435492095033301 0.616608398044492 22.526111888978143 -10.389229436046035 5.95008978039128 1.0001207251718913 0.48007880377401696 0.8285889072226221 0.11147594691738028 0.00017856798526052283 1.8329854839717564e-05 0.10796088619835444 0.03597870715947612 4.081037297965109e-11 10.389229436046035 -0.5200419213978744 QLLCGAAIGTHEDDKYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLLCGAAIGTHEDDKYR 17 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 27224800.0 6331200.0 8995600.0 11898000.0 False True 8672015.734246718 8598144.6475288 9087937.447001778 1.0 0.9914816705848222 1.0479613650967607 23.04793594360119 -6.868483762877919 1.1421598079023938 0.9952243003858918 1.0511741313195466 0.9631424816712388 0.0047729689832293485 0.1383130194625243 0.3381861566247698 0.003246187895925497 0.0076654890341248585 1.3536807002666136e-07 6.868483762877919 0.0559498309336548 QLLCGAAVGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLLCGAAVGTR 11 0 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 10982800.0 2677900.0 5155800.0 3149100.0 False True 3510752.8328204914 4386574.737150993 2823261.340300211 1.0 1.2494684035124393 0.8041754788052229 21.743348999203842 -6.754677059125645 1.6325091892109487 1.145859971646945 0.8029629901381419 0.6688689591120202 0.10486197888529115 0.2919508188284231 1.5321782598736857 0.05071267192869749 0.12251953756092862 1.759231290057443e-07 6.754677059125645 -0.3428969815088032 QLLCGAAVGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLLCGAAVGTR 11 0 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4;C9K0R9 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 9019700.0 2677900.0 2651600.0 3690200.0 False True 3667991.9975264254 2534443.544331385 2818650.7620546296 1.0 0.690962124792129 0.7684451776218258 21.806559060726734 -10.39630804614921 5.647708259916405 1.000105284428731 0.7297036512069771 0.9419474827201968 0.03163232385764813 4.195056513608221e-05 4.4841496643576585e-06 0.03063973829009617 0.01020928862520876 4.0150592068252305e-11 10.39630804614921 -0.2704016332217539 QLLDDEEQLTAK(ub)TLYMSHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLLDDEEQLTAKTLYMSHR 19 1 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 17661400.0 5436000.0 7806100.0 4419300.0 True False 7126648.64229888 6641460.307939476 3962033.228918974 1.0 0.9319191447885252 0.5559461996488886 22.76479236776035 -6.9376156041961154 0.6813912845198387 1.004444830399961 0.4612977211160218 0.9978345086486015 0.009086870709840333 0.08887169962417331 0.059692249590543214 0.008693017007045035 0.03271376051317922 1.1544746359148398e-07 6.9376156041961154 -0.5431471092839391 QLLDDEEQLTAK(ub)TLYMSHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLLDDEEQLTAKTLYMSHR 19 1 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 30404300.0 9963200.0 9573100.0 10868000.0 True False 9646923.669579957 13395688.753056984 8021344.766988662 1.0 1.3885969467446047 0.8314925090868812 23.201637520593902 -6.719139358070743 1.7622277243178723 1.2366326049260044 0.8323920695091358 0.5085227697105565 0.16354057613328235 0.35699928069193576 2.1661456160659243 0.07369749871034445 0.18520871686175325 1.9092405158789557e-07 6.719139358070743 -0.40424053541686855 QLLDDEEQLTAK(ub)TLYMSHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLLDDEEQLTAKTLYMSHR 19 1 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 24052100.0 9963200.0 9186600.0 4902300.0 True False 8284842.244597664 9137109.962402675 5927348.264325802 1.0 1.102870723743805 0.7154449160683628 22.98204279602818 -6.8360746009717195 1.3003693874848201 1.0547846715629883 0.7036512764326899 0.9175091876787966 0.04706275997237939 0.1734378091533287 0.571358639974645 0.028394994343256937 0.06536842621188965 1.4585636938523513e-07 6.8360746009717195 -0.3511333951302984 QLLDDEEQLTAK(ub)TLYMSHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLLDDEEQLTAKTLYMSHR 19 1 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 81680000.0 23452000.0 32028000.0 26200000.0 True False 30359076.308032207 30245613.645125296 21431868.834701814 1.0 0.9962626444310859 0.7059460115732016 24.855624560824808 -6.909707819972592 0.897723519755941 1.0090720464134835 0.6686611557068535 0.9908108120560336 0.013204358030178292 0.10461151272401853 0.1398181027830578 0.01079499250336159 0.029739038039340342 1.2310967364488493e-07 6.909707819972592 -0.34041089070663 QLLDQVEQIQK(ub)EQDYQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLLDQVEQIQKEQDYQR 17 1 Q7Z7H5;Q7Z7H5-2;Q7Z7H5-3 Q7Z7H5 TMED4 Transmembrane emp24 domain-containing protein 4 1 25259800.0 2584400.0 3647400.0 19028000.0 True False 2149043.1083324854 3627750.7322477885 23006666.824468378 1.0 1.688077227572546 10.705539937874965 21.035262991854285 -6.922164070857276 0.8085327822986246 0.8161185884954293 12.234525790723138 0.9947607945706538 0.3200737164460605 0.09691540200905265 0.09914455313318905 0.27898318590838367 0.853763008436644 1.1962885035508175e-07 6.922164070857276 11.418407202227709 up QLLHEK(ub)IR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLLHEKIR 8 1 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 46415100.0 4256800.0 5694300.0 36464000.0 True False 5510511.514072625 5377407.199308014 29827926.152235396 1.0 0.9758453794308037 5.4129142233096665 22.393754812723927 -6.905672730814662 0.9246855401396005 0.8431203175318973 5.936294750837834 0.9891839152822742 0.21694321899351895 0.10735000827064116 0.1547981196897734 0.173898525835774 0.4668049525701433 1.2425883261279732e-07 6.905672730814662 5.093174433305936 up QLLHNFPPDQLTSSGAPFWSGPK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLLHNFPPDQLTSSGAPFWSGPKR 24 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 43958100.0 22003900.0 18312900.0 3641300.0 True False 21305398.238825932 25625336.470511913 2687534.293341538 1.0 1.2027626136465985 0.1261433493622243 24.344715682721784 -6.857983696578319 1.1957764439865957 1.109485168583617 0.07595503633946593 0.9511497317648621 0.10324429520349193 0.14889858562299152 0.4057005055158749 0.06739121371959857 0.15698205243147606 1.38680788868467e-07 6.857983696578319 -1.033530132244151 down QLLHNFPPDQLTSSGAPFWSGPK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLLHNFPPDQLTSSGAPFWSGPKR 24 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 95844000.0 38826000.0 21710000.0 35308000.0 True False 58901880.56081011 17835680.878995806 28329358.323953867 1.0 0.3028032502388834 0.48095846947886034 25.81181035993865 -10.732062150120516 10.37081146560276 1.0010121753281809 0.3918808598627974 0.9395232358483494 0.07273156369193531 0.0017039705470349592 4.4023274091352535e-05 0.07049804461041556 0.023474011243540795 1.853266391006237e-11 10.732062150120516 -0.6091313154653835 QLLHNFPPDQLTSSGAPFWSGPK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLLHNFPPDQLTSSGAPFWSGPKR 24 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 35913500.0 3129300.0 23256800.0 9527400.0 True False 4286286.776152741 22229237.676046968 7277224.342962252 1.0 5.186129355534944 1.6977922204015705 22.031296946798427 -6.60135934974844 2.185995300353741 3.812849831151811 1.709369190488385 0.024332246810557456 1.8087676557395165 0.6368704617751927 5.7538098598090945 0.6864073818492259 2.011016573297928 2.504036472259694e-07 6.60135934974844 -2.1034806406634257 QLLHNFPPDQLTSSGAPFWSGPK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLLHNFPPDQLTSSGAPFWSGPKR 24 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 39262800.0 22003900.0 11928000.0 5330900.0 True False 18297217.788050286 11863741.496477379 6445566.542703308 1.0 0.6483904620857417 0.35227030783405977 24.12512095815606 -7.53317458709399 0.23011872517386456 1.1588979139106008 2.47685445456836e-11 0.9998985164243829 0.0026671387150901922 0.12896805681220325 0.023314968488350234 0.030886399685258355 0.06801685441540228 2.9297152581511534e-08 7.53317458709399 -1.1588979138858322 down QLLHNFPPDQLTSSGAPFWSGPK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLLHNFPPDQLTSSGAPFWSGPKR 24 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 126365300.0 38826000.0 47938100.0 39601200.0 True False 50261022.37487881 45270302.59402336 32394187.942625724 1.0 0.9007039740729611 0.6445190808298562 25.5829366820311 -6.954783065489907 0.5036056309158279 1.0049740951696475 0.52913151917719 0.9995251391296137 0.0032634972861800824 0.0816200855789951 0.028439671104234992 0.003801779431301831 0.021135956606136853 1.1097289977603043e-07 6.954783065489907 -0.4758425759924575 QLLLESQSQLDAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLLLESQSQLDAAK 14 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5;A0A087WU26 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 986790.0 986790.0 0.0 0.0 False True 1293691.2460879532 0.0 0.0 1.0 0.0 0.0 20.30306191239811 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 QLLLESQSQLDAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLLLESQSQLDAAK 14 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5;A0A087WU26 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 2439090.0 986790.0 0.0 1452300.0 False True 1351632.9299970493 0.0 1109296.6510573796 1.0 0.0 0.8207085122288351 20.366271973921002 -9.569407565508788 10.81701151780339 0.9999838639686346 0.41035425611438875 0.40766898354128744 0.33505284721608 0.0 0.0 0.3244135242832917 0.10813784142776388 2.6952089149419967e-10 9.569407565508788 -0.5896296078542458 QLLLFQFAHHLELWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLLLFQFAHHLELWR 15 0 Q969X6;H3BSH7;Q969X6-3;Q969X6-2;A0A0J9YWM9;A0A0J9YWK2;A0A0J9YXV4 Q969X6 CIRH1A Cirhin 0 28485800.0 3449000.0 12177300.0 12859500.0 False True 5232385.155674909 10004165.673320832 10317814.188480921 1.0 1.9119704256615309 1.9719141235790885 22.319037310796737 -11.027404150210549 0.48059406965720947 1.1194235229680124e-20 1.9704573509393313 0.9997479495924625 0.0070602511220618485 2.8709644347578633 0.23375339788583444 3.1749717047830877 0.012654206915606302 9.38849219987162e-12 11.027404150210549 1.9704573509393313 QLLLFQFAHHLELWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLLLFQFAHHLELWR 15 0 Q969X6;H3BSH7;Q969X6-3;Q969X6-2;A0A0J9YWM9;A0A0J9YWK2;A0A0J9YXV4 Q969X6 CIRH1A Cirhin 0 24108300.0 3449000.0 10930200.0 9729100.0 False True 4464798.489954076 10321924.76158201 7958503.628996076 1.0 2.3118456039632327 1.7825000718180086 22.090163632889187 -9.896145126982397 5.648595728779225 0.9999993907673006 2.047172837892978 0.8391743762715329 0.21610440857129665 1.6582010954319084e-06 3.2401677022336507e-07 0.20924231544257213 0.06974739795200843 1.2701495919172137e-10 9.896145126982397 1.0471734471256773 QLLLSFK(ub)PVMQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLLLSFKPVMQK 12 1 D3DQV9;P78344;H0Y3P2;P78344-2;H0YE22 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 1 16272100.0 2081500.0 2692600.0 11498000.0 True False 3157787.6780334353 2212084.4926201794 9225415.260247564 1.0 0.7005171715654397 2.9214805429834487 21.5904827404761 -6.8728871491561945 1.118778508961868 0.8272935548544548 3.05885253691615 0.9674773290959437 0.1774565285764969 0.1341132441137711 0.31199552749976456 0.12287552985129394 0.29244692796308813 1.3400248458645964e-07 6.8728871491561945 2.2315589820616952 up QLLLSFK(ub)PVMQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLLLSFKPVMQK 12 1 D3DQV9;P78344;H0Y3P2;P78344-2;H0YE22 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 1 14266900.0 2081500.0 3146700.0 9038700.0 True False 2694542.7824991024 2971583.378828395 7393749.34489386 1.0 1.1028154379765855 2.743971776182523 21.36160906256855 -6.919684286641271 0.8270646333559794 0.9633751504153218 3.0067109267385095 0.9940927650686715 0.061408869434581057 0.09835796627633456 0.10657944036099971 0.052821711021222274 0.15775182096056178 1.2031387467669946e-07 6.919684286641271 2.043335776323188 up QLLLSFKPVMQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLLLSFKPVMQK 12 1 D3DQV9;P78344;H0Y3P2;P78344-2;H0YE22 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 11376500.0 2491700.0 3656400.0 5228400.0 False True 3266642.829657127 3110879.37253557 4687415.322354202 1.0 0.9523169610992009 1.4349335286362488 21.639377290383642 -6.882611052412176 1.0651606629396206 0.9692918585524684 1.470891743556458 0.9757300109901033 0.033828328828460236 0.12534095348081825 0.2585394261285787 0.02440482728441289 0.05942721864593105 1.3103549317702234e-07 6.882611052412176 0.5015998850039896 QLLLSFKPVMQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLLLSFKPVMQK 12 1 D3DQV9;P78344;H0Y3P2;P78344-2;H0YE22 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 6438200.0 2407600.0 1637600.0 2393000.0 False True 2331172.0558536113 2291502.2199711846 1766201.5115388192 1.0 0.9829828794563596 0.7576452828112186 21.152624058117958 -6.9220227806287395 0.8095865456723279 1.004618815048221 0.7195617791892537 0.9947245233481797 0.008022605732396269 0.09699620990179367 0.09955498798829289 0.006987382973264708 0.021352871386097656 1.1966777587234977e-07 6.9220227806287395 -0.28505703585896724 QLLLSFKPVMQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLLLSFKPVMQK 12 1 D3DQV9;P78344;H0Y3P2;P78344-2;H0YE22 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 10070700.0 2471100.0 7599600.0 0.0 False True 3748839.361608657 6243392.004054191 0.0 1.0 1.6654199878479459 0.0 21.838012576551723 -6.811921241084376 1.4971716341407157 1.367091594748405 3.6821970951075115e-20 0.8265610427832767 0.28505151953155544 0.21510986050164604 0.9642817691100791 0.15174749109247632 0.33677923107694707 1.541980064299833e-07 6.811921241084376 -1.367091594748405 QLLLSFKPVMQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLLLSFKPVMQK 12 1 D3DQV9;P78344;H0Y3P2;P78344-2;H0YE22 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 12756900.0 2491700.0 3981200.0 6284000.0 False True 3412948.8256606283 3805297.419932155 4799848.6230424605 1.0 1.1149588271941293 1.4063640764122436 21.702587351906534 -6.955164304304064 0.49894157270177525 0.9941101350003935 1.5397586634866884 0.999546694115369 0.0036414124671615075 0.08147596663141658 0.027875572177329236 0.004278984938937164 0.024037472039334658 1.1087552664661596e-07 6.955164304304064 0.545648528486295 QLLLSFKPVMQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLLLSFKPVMQK 12 1 D3DQV9;P78344;H0Y3P2;P78344-2;H0YE22 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 6176000.0 2407600.0 1355900.0 2412500.0 False True 2002026.0747644664 1348595.4975749217 2916942.5958603113 1.0 0.673615351255393 1.4569953072182054 20.933029333552234 -6.793544113697422 1.4820726807851234 0.8184147302241789 1.466166660679896 0.8125992348485046 0.13908661111041734 0.2301224480353502 0.9984472750641885 0.07385187489809482 0.17247504698988655 1.608628972230068e-07 6.793544113697422 0.6477519304557171 QLLLSFKPVMQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLLLSFKPVMQK 12 1 D3DQV9;P78344;H0Y3P2;P78344-2;H0YE22 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 16347200.0 2471100.0 8346200.0 5529900.0 False True 3198887.662663238 7881726.633100566 4523514.9415655555 1.0 2.4638960364549423 1.4140899645720904 21.609138898644172 -10.200263571954606 5.780125682142127 0.9999776099395875 1.9389930005135336 0.516138556284127 0.428581534164831 0.00012367103705922486 1.711116921252995e-05 0.4149821424759273 0.1383240953593573 6.305745346278652e-11 10.200263571954606 0.9390153905739461 QLLLTADDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLLLTADDR 9 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 106439000.0 17075000.0 50961000.0 38403000.0 False True 22385490.354535215 43357817.4444221 34429425.94758789 1.0 1.9368714626185517 1.5380242023875355 24.416060585057775 -10.593634085284624 7.858964850186164 0.9995278202491468 1.737447832502933 0.820083852214799 0.16282871214550795 0.0013479081953458572 6.969650381218454e-05 0.1577476257439323 0.05255274086866276 2.5489769880646136e-11 10.593634085284624 0.7379200122537862 QLLLTADDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLLLTADDR 9 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 73966000.0 23548000.0 12209000.0 38209000.0 False True 22800481.62952353 17084117.369093902 28200916.65457032 1.0 0.7492875653544216 1.2368561819349446 24.44256096391674 -6.766953258714336 1.5863299021529107 0.8556396062001534 1.239275348760217 0.7187122140849591 0.10558300214495796 0.27137462517704186 1.3472769203732242 0.052480051178549 0.12526589673981306 1.7101993667395512e-07 6.766953258714336 0.3836357425600636 QLLLTADDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLLLTADDR 9 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 299072000.0 15308000.0 267720000.0 16044000.0 False True 23223355.164706126 219943274.2940929 12872896.367664978 1.0 9.470779425892491 0.5543082072494272 24.46907308300438 -6.65775546608793 1.9808116546806696 6.462458531315219 0.5915343830008916 0.22620034010894363 3.6085817364275488 0.4897357805915621 3.691450687832932 1.4730487791666567 3.999493887470818 2.1990977485404994e-07 6.65775546608793 -5.8709241483143275 QLLLTADDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLLLTADDR 9 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 95346000.0 17075000.0 33331000.0 44940000.0 False True 23388088.934524693 31858326.209122542 34326097.56835269 1.0 1.3621602987020618 1.467674321935799 24.479270646580666 -12.340851788234994 0.19777502615071071 4.90004712959478e-09 1.54368141737726 0.9994230881621288 0.004810545373014239 6.171179604391241 0.1281189491605707 2.540455453992548 0.0680099484590625 4.561925743204039e-13 12.340851788234994 1.543681412477213 QLLLTADDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLLLTADDR 9 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 37008000.0 23548000.0 13460000.0 0.0 False True 19581205.353278648 13387488.308399174 0.0 1.0 0.6836907160139452 0.0 24.222966239351017 -7.461881104092692 0.7317097863269331 0.9919607055234348 2.2463194447019738e-17 0.987179543167744 0.04725329831962564 0.11718901195418184 0.14094992711942797 0.04139723922939794 0.07469618355134351 3.4523824156293476e-08 7.461881104092692 -0.9919607055234348 down QLLLTADDRVNPCIGGVILFHETLYQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLLLTADDRVNPCIGGVILFHETLYQK 27 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 272082900.0 61862900.0 107410000.0 102810000.0 False True 93850542.08379267 88241846.30183959 82489558.43677616 1.0 0.9402380033463689 0.8789459986616479 26.483861742345372 -6.970809213024339 0.23806987882359829 1.0225417963006616 0.79487365135461 0.9999880099711314 0.00017103220726294931 0.07604104481558774 0.008084869428570722 0.0014853449749359202 0.005996087704805638 1.0695246216734916e-07 6.970809213024339 -0.2276681449460516 QLLLTADDRVNPCIGGVILFHETLYQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLLLTADDRVNPCIGGVILFHETLYQK 27 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 186509300.0 61862900.0 42638600.0 82007800.0 False True 80082743.55006659 40265724.427658245 67083221.87108626 1.0 0.5028015105711843 0.8376738720139725 26.25498806443782 -9.935010298401668 5.586880530848792 1.0000003700247597 0.6702376912919903 0.5638808316812577 0.13671106908469696 6.301573617333242e-07 1.2003833105085352e-07 0.13237007335530074 0.04412330781696776 1.1614210727984334e-10 9.935010298401668 -0.32976267873276943 QLLLVSLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLLLVSLTR 9 0 Q14146 Q14146 URB2 Unhealthy ribosome biogenesis protein 2 homolog 0 2837400.0 0.0 1029900.0 1807500.0 False True 0.0 984395.6125761399 1380605.7266310079 0.0 QLLNLVVIGHVDAGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLLNLVVIGHVDAGK 15 0 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;E9PHZ9;E9PS53 Q9Y450 HBS1L HBS1-like protein 0 17946700.0 3591000.0 7872800.0 6482900.0 False True 5447809.537265469 6467837.329532844 5201551.973443987 1.0 1.187236316778317 0.9547969579081336 22.377244835000543 -6.6923217049897 1.8583160499855618 1.1171292157295911 0.9555801063334735 0.3812751138528955 0.07915081370325018 0.41168131387253215 2.75818722596094 0.03405217846830604 0.08841071646737995 2.0308520936072853e-07 6.6923217049897 -0.16154910939611766 QLLNLVVIGHVDAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLLNLVVIGHVDAGK 15 0 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;E9PHZ9;E9PS53 Q9Y450 HBS1L HBS1-like protein 0 15277200.0 3591000.0 5156200.0 6530000.0 False True 4648620.289192546 4869252.9373359205 5341607.003458123 1.0 1.0474619638554514 1.1490736328533184 22.148371157092992 -6.958691608808926 0.4534965582971078 0.9968378411656467 1.2037495561036902 0.9997185457421296 0.0010432030725432665 0.0801718508214814 0.022883500341094404 0.00136541583000187 0.00840080277174598 1.0997865172831207e-07 6.958691608808926 0.2069117149380435 QLLQANPILEAFGNAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLLQANPILEAFGNAK 16 0 P35579;P35579-2;P35749-2;P35749;P35749-3;P35749-4;A0A494C024;A0A2R8Y4C3;Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4;M0QY43 P35579;Q7Z406 MYH9;MYH11;MYH14 Myosin-9;Myosin-11;Myosin-14 0 18978700.0 1292700.0 12870000.0 4816000.0 False True 1694742.218524607 10949846.166867068 4317686.518334076 1.0 6.461068855887525 2.547695142741489 20.692634415937135 -6.559773439838425 2.347536122905463 4.762641527714855 2.5538014404611635 0.0 2.3844621808970707 0.7618219853895188 7.867965131896069 0.8642614278843677 2.682398509426394 2.755665887820747e-07 6.559773439838425 -2.2088400872536917 QLLQANPILEAFGNAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLLQANPILEAFGNAK 16 0 P35579;P35579-2;P35749-2;P35749;P35749-3;P35749-4;A0A494C024;A0A2R8Y4C3;Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4;M0QY43 P35579;Q7Z406 MYH9;MYH11;MYH14 Myosin-9;Myosin-11;Myosin-14 0 18089400.0 7750400.0 4730800.0 5608200.0 False True 7504367.794354476 6619833.110796084 4139244.1776063526 1.0 0.8821306860487533 0.551577999777716 22.83929910641096 -6.952955947139701 0.5253926818915592 1.0053918666778452 0.41342885292430986 0.999413295149189 0.004597501738091226 0.08232007864124082 0.031214945130050138 0.00516478151459231 0.027319545213800936 1.1144075683024499e-07 6.952955947139701 -0.5919630137535353 QLLQANPILEAFGNAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLLQANPILEAFGNAK 16 0 P35579;P35579-2;P35749-2;P35749;P35749-3;P35749-4;A0A494C024;A0A2R8Y4C3;Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4;M0QY43 P35579;Q7Z406 MYH9;MYH11;MYH14 Myosin-9;Myosin-11;Myosin-14 0 21471100.0 1292700.0 9370400.0 10808000.0 False True 1770646.1239039567 8956384.744230937 8255372.9977471195 1.0 5.058257899937519 4.662350588465133 20.755844477460027 -10.24353496183397 4.65282248536918 0.9988333950026232 4.860304244218101 0.9921730480883403 0.16162848314814557 28526569.284275725 724.4867533597943 356536.81230830407 0.05532972883863695 5.7077512544200273e-11 10.24353496183397 3.8614708492154777 QLLQANPILEAFGNAK(ub)TVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLLQANPILEAFGNAKTVK 19 1 P35579;P35579-2;P35749-2;P35749;P35749-3;P35749-4;A0A494C024;A0A2R8Y4C3;Q7Z406;Q7Z406-6;Q7Z406-2;Q7Z406-5;Q7Z406-4;M0QY43 P35579;Q7Z406 MYH9;MYH11;MYH14 Myosin-9;Myosin-11;Myosin-14 1 27613600.0 8514300.0 9395000.0 9704300.0 True False 7080017.697444381 9344387.270238511 11733424.262386413 1.0 1.3198254113985453 1.6572591713466671 22.755321535844782 -6.970447372838945 0.24726654729622274 0.8892482834436498 2.097685120058957 0.999985664580287 0.001016040851998493 0.07615779496470364 0.00850908638117751 0.007667605439305973 0.03248629403887619 1.0704160864860158e-07 6.970447372838945 1.208436836615307 QLLQLYLQALEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLLQLYLQALEK 12 0 O00273-2;O00273 O00273-2 DFFA DNA fragmentation factor subunit alpha 0 3369370.0 1984300.0 1064100.0 320970.0 False True 2601436.5159885352 905340.427829314 287759.103361646 1.0 0.3480155761115271 0.11061546249276766 21.31087707034009 -9.885156566911187 0.2660440434221405 1.5045134852255038 4.530931060960389e-26 0.998964484034034 0.012099767012838453 1.326016929220337 0.11877234033995092 0.6116619901815301 0.09664788834879545 1.3026970602486604e-10 9.885156566911187 -1.5045134852255038 QLLQLYLQALEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLLQLYLQALEK 12 0 O00273-2;O00273 O00273-2 DFFA DNA fragmentation factor subunit alpha 0 28501800.0 14879000.0 8397600.0 5225200.0 False True 14406674.289352834 11750805.472905485 3856563.36736006 1.0 0.8156501102818606 0.2676928269427338 23.780233999029445 -6.951658432045013 0.5403300122490186 1.0080498769543345 0.049974053794404664 0.9993250870197312 0.008079618768085984 0.0828265530210123 0.03325860194012884 0.008882640988345344 0.04538101432192112 1.1177419942707777e-07 6.951658432045013 -0.9580758231599298 down QLLQLYLQALEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLLQLYLQALEK 12 0 O00273-2;O00273 O00273-2 DFFA DNA fragmentation factor subunit alpha 0 182152000.0 51761000.0 71825000.0 58566000.0 False True 78525221.23597823 59007267.57871366 46990404.429610334 1.0 0.7514435063021262 0.5984116146377764 26.226652766725504 -10.241442971836236 0.07720281366862075 1.8736520957837672 3.276656526646712e-11 0.9999691720370383 0.000918812011554961 1.9920103237487319 0.03907518929343199 0.6515139771066617 0.32493492894523784 5.735311732415043e-11 10.241442971836236 -1.8736520957510008 QLLQLYLQALEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLLQLYLQALEK 12 0 O00273-2;O00273 O00273-2 DFFA DNA fragmentation factor subunit alpha 0 7649800.0 1984300.0 1088200.0 4577300.0 False True 2717949.333691207 1040119.725803821 3496236.012452616 1.0 0.3826854727977028 1.28635069429511 21.374087131862982 -6.722790639671135 1.7491109819248878 0.6255617380227416 1.285184230766123 0.5257285903944293 0.2596831195968745 0.34992250627227134 2.0936255444022276 0.11781228708691749 0.29480478525958426 1.8932560805983961e-07 6.722790639671135 0.6596224927433814 QLLQLYLQALEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLLQLYLQALEK 12 0 O00273-2;O00273 O00273-2 DFFA DNA fragmentation factor subunit alpha 0 25149000.0 14879000.0 4055300.0 6214700.0 False True 12372547.751462243 4033453.2939859712 7514165.036473824 1.0 0.32600022040806265 0.6073256040240997 23.56063927446372 -10.413219142532848 6.013143323951611 1.0001579808293746 0.4666629122162823 0.8273505847376026 0.11485060692533829 0.00024331430570498957 2.3743168018924582e-05 0.11123602474588877 0.037067873993637326 3.8617206764761584e-11 10.413219142532848 -0.5334950686130923 QLLQLYLQALEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLLQLYLQALEK 12 0 O00273-2;O00273 O00273-2 DFFA DNA fragmentation factor subunit alpha 0 144729000.0 51761000.0 45224000.0 47744000.0 False True 67005634.86184775 42707244.64490902 39055081.894809306 1.0 0.6373679576794226 0.5828626499149376 25.997779088817953 -13.999999999715506 0.26683457723933657 3.7519636504746474 0.5642079911887219 0.9995765675302346 0.0038096168099781393 14.73027885884391 0.16349768431312944 21.948329161247514 0.023001094212449377 1.0000000006550721e-14 13.999999999715506 -3.1877556592859255 QLLSLAANGIQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLLSLAANGIQR 12 0 Q5JRG1;H7BYF2;Q9BVL2-2;Q9BVL2-3;Q9BVL2 Q5JRG1 NUPL1 Nucleoporin p58/p45 0 5363100.0 1685700.0 1689900.0 1987500.0 False True 2209969.0243420233 1437773.5071786058 1781852.5654462143 1.0 0.6505853662843423 0.8062794300823865 21.075594717790956 -10.169056992907223 5.148167521061663 1.0000142065236277 0.7284323982729961 0.8022344032722066 0.06356183538171432 1.0450033502769071e-05 1.6867609941348204e-06 0.061546726294072866 0.020514494157199133 6.775525858601748e-11 10.169056992907223 -0.2715818082506316 QLLSLAANGIQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLLSLAANGIQR 12 0 Q5JRG1;H7BYF2;Q9BVL2-2;Q9BVL2-3;Q9BVL2 Q5JRG1 NUPL1 Nucleoporin p58/p45 0 4532420.0 1586100.0 924920.0 2021400.0 False True 1535750.1236872443 1294245.379394081 1491934.6992998617 1.0 0.842744766503209 0.9714696917736954 20.550512068818726 -10.150394609698369 4.7234423387745235 1.0000090140468518 0.9071072291376828 0.4098025175504689 0.05255173068440507 4.988936976452859e-06 8.973307256706678e-07 0.050887931136279145 0.016960998145882315 7.073028211297253e-11 10.150394609698369 -0.092901784909169 QLLTLSSELSQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLLTLSSELSQAR 13 0 P15311;E7EQR4 P15311 EZR Ezrin 0 119859000.0 41420000.0 50512000.0 27927000.0 False True 54302021.11185056 42975806.494233884 25037381.934700117 1.0 0.7914218589711957 0.46107642813383426 25.694502560100833 -6.96433807547012 0.3692365101479089 1.0256247055865908 0.21538853606445935 0.9998988429035903 0.0022315797252915447 0.07818631094025989 0.01565635091231596 0.004359319661164847 0.02806758334282572 1.0855802273563631e-07 6.96433807547012 -0.8102361695221314 down QLLTLSSELSQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLLTLSSELSQAR 13 0 P15311;E7EQR4 P15311 EZR Ezrin 0 98759000.0 27018000.0 23142000.0 48599000.0 False True 26160328.378905464 32382721.28393575 35869463.961251564 1.0 1.237856070264307 1.3711396677334953 24.64087731466699 -12.215892915578214 0.0814669490805206 1.86781259723595e-21 1.7964576181959115 0.9999186436211589 0.0013846034986405697 6.3304563767230935 0.06367243821994248 1.4170307999289813 0.3253288878328205 6.082849682180298e-13 12.215892915578214 1.7964576181959115 QLLTLSSELSQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLLTLSSELSQAR 13 0 P15311;E7EQR4 P15311 EZR Ezrin 0 122218000.0 23787000.0 68991000.0 29440000.0 False True 36086618.06263818 56679017.02085673 23621171.09598962 1.0 1.5706380942230391 0.6545687117309975 25.104960608419766 -6.738252888037993 1.6931006008013552 1.3402113504422826 0.654233971330619 0.5970792157109281 0.23976937220712569 0.32098193597193697 1.80598547661131 0.11206351498550485 0.27552213122917457 1.8270360301510716e-07 6.738252888037993 -0.6859773791116636 QLLTLSSELSQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLLTLSSELSQAR 13 0 P15311;E7EQR4 P15311 EZR Ezrin 0 95628000.0 41420000.0 27841000.0 26367000.0 False True 56734093.333412156 26610892.562124744 20139657.645410676 1.0 0.4690458769780482 0.35498333474820715 25.757712621623725 -13.99999999999991 0.2161414770071933 4.150877570663087 0.2916685811733917 0.999494332547554 0.006320281329579527 12.89750568832118 0.1473107103885483 17.31065207800735 0.06477101739128117 1.0000000000002086e-14 13.99999999999991 -3.8592089894896953 QLLTLSSELSQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLLTLSSELSQAR 13 0 P15311;E7EQR4 P15311 EZR Ezrin 0 51475000.0 27018000.0 12712000.0 11745000.0 False True 22466664.1003432 12643517.932865547 14200825.197255706 1.0 0.5627679247971845 0.632084279794737 24.421282590101267 -10.663718175475589 6.662192091863958 1.0023145762920118 0.5974261022959803 0.9782484279711217 0.02829828342893706 0.0009772206175395124 4.932630797043242e-05 0.02752249233645863 0.009133231703877545 2.1691112386075494e-11 10.663718175475589 -0.40488847399603156 QLLTLSSELSQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLLTLSSELSQAR 13 0 P15311;E7EQR4 P15311 EZR Ezrin 0 82202000.0 23787000.0 35822000.0 22593000.0 False True 30792740.411869418 33828474.20993128 18481305.823756397 1.0 1.0985860224668962 0.6001838607593549 24.876086930512216 -6.8553182320843895 1.2091253259666788 1.0529560867887884 0.5781154755618773 0.9476969464033088 0.04928541143869703 0.15170176379396177 0.4241237900378423 0.03184630008507511 0.07399141742893466 1.3953455379136272e-07 6.8553182320843895 -0.4748406112269111 QLLYLEK(ub)YRPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLLYLEKYRPK 11 2 A0A0D9SGK2;Q93096;Q12974-3;Q12974-4;Q12974 A0A0D9SGK2;Q12974-4 PTP4A1;PTP4A2 Protein tyrosine phosphatase type IVA 1;Protein tyrosine phosphatase type IVA 2 1 15352300.0 7681300.0 5707900.0 1963100.0 True False 7437461.3360310355 7987094.236305275 1448905.2182623718 1.0 1.0739006060591567 0.1948117983811359 22.826378832738165 -6.88648355552658 1.0430008134211601 1.0512929582282091 0.12422348305358279 0.9785489034074712 0.05831127573610664 0.1220409364677936 0.23890628534836433 0.04278407131054815 0.10539281623377164 1.2987227387740837e-07 6.88648355552658 -0.9270694751746263 down QLMLYYHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLMLYYHR 8 0 P57076;H7C2R6;H7BZW1 P57076 C21orf59 UPF0769 protein C21orf59 0 4910900.0 1269300.0 1641600.0 2000000.0 False True 1664064.5919186855 1396679.6789066817 1793059.185354681 1.0 0.8393181885423655 1.0775177802967753 20.666280003183104 -6.725045201034878 1.7417834301290152 0.9027698096715144 1.0772401220507015 0.5359439649459784 0.0675770422599838 0.34560028791872954 2.0517698361454 0.030778672500094577 0.076793145309417 1.8834530509466216e-07 6.725045201034878 0.1744703123791871 QLMLYYHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLMLYYHR 8 0 P57076;H7C2R6;H7BZW1 P57076 C21orf59 UPF0769 protein C21orf59 0 4837800.0 1269300.0 2035500.0 1533000.0 False True 1738594.511542735 1945564.8795016322 1170936.9731260494 1.0 1.1190446458819445 0.673496301381409 20.729490064705995 -6.835626632563815 1.3026805063520097 1.0634051488442078 0.6600774896654197 0.9166449414455123 0.05437973960300259 0.17397243069217697 0.5753805289261948 0.03275595283234099 0.07539250521119925 1.4600689571707835e-07 6.835626632563815 -0.4033276591787881 QLNDVK(ub)TTVVYPATEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLNDVKTTVVYPATEK 16 1 Q96C86 Q96C86 DCPS m7GpppX diphosphatase 1 54924000.0 17569000.0 22668000.0 14687000.0 True False 23033129.138438027 19286022.759171933 13167330.127652105 1.0 0.8373166599837767 0.5716691834839874 24.457207084280384 -6.9638080359427965 0.37795292655688045 1.0186726486334785 0.3809496839255178 0.999886423619943 0.0018814318477541317 0.07836782032008098 0.016300747864022015 0.0034647837841422667 0.022469262146257225 1.0869059446389558e-07 6.9638080359427965 -0.6377229647079607 QLNDVK(ub)TTVVYPATEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLNDVKTTVVYPATEK 16 1 Q96C86 Q96C86 DCPS m7GpppX diphosphatase 1 61866000.0 21752000.0 23665000.0 16449000.0 True False 21061494.66644285 33114557.911344666 12140513.440577535 1.0 1.5722795763448778 0.576431712603994 24.328104487628753 -6.750832174868035 1.6465221188744061 1.3361587766806151 0.5742940060690246 0.6526787434711485 0.24048677578233013 0.2985772982881196 1.5928095674264406 0.1153614946816808 0.27984895246350067 1.7748752163399277e-07 6.750832174868035 -0.7618647706115905 QLNDVK(ub)TTVVYPATEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLNDVKTTVVYPATEK 16 1 Q96C86 Q96C86 DCPS m7GpppX diphosphatase 1 85001900.0 35980900.0 20323000.0 28698000.0 True False 54585655.85613901 16696201.865676267 23025827.721219745 1.0 0.30587159948538967 0.4218292765759657 25.702018550447985 -10.210034736138942 7.758180793318527 1.0000004730051355 0.3638504380389657 0.9756862469223988 0.04733952343838831 3.872635274842421e-07 3.944104239699882e-08 0.04583632993796053 0.015278765491189472 6.16545686767626e-11 10.210034736138942 -0.6361500349661697 QLNDVK(ub)TTVVYPATEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLNDVKTTVVYPATEK 16 1 Q96C86 Q96C86 DCPS m7GpppX diphosphatase 1 45398000.0 17569000.0 12943000.0 14886000.0 True False 24064734.084372733 12371135.463222604 11370233.38679345 1.0 0.5140773806121642 0.4724853117814879 24.520417145803275 -13.999999999999998 0.34812799115864534 6.907222745714449 0.4665958273023125 0.9997511261459691 0.0037778459544227914 20.475121091650518 0.18980447128254652 89.36324626229991 0.012489571126731871 1.0000000000000041e-14 13.999999999999998 -6.4406269184121365 QLNDVK(ub)TTVVYPATEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLNDVKTTVVYPATEK 16 1 Q96C86 Q96C86 DCPS m7GpppX diphosphatase 1 58769000.0 21752000.0 24475000.0 12542000.0 True False 18087751.77698817 24343148.317092847 15164474.212344052 1.0 1.3458360451442615 0.8383835868223707 24.10850976306303 -6.7232324167743505 1.7477777550088858 1.2096769146430255 0.8390333515947639 0.5276491543779273 0.1454747918806343 0.34909254883747914 2.085756181141365 0.06604656709819152 0.16516870351090845 1.891331184100558e-07 6.7232324167743505 -0.3706435630482616 QLNDVK(ub)TTVVYPATEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLNDVKTTVVYPATEK 16 1 Q96C86 Q96C86 DCPS m7GpppX diphosphatase 1 79613900.0 35980900.0 21632000.0 22001000.0 True False 46577984.33957341 20428160.18394373 17997043.749323435 1.0 0.438579738337617 0.38638519902701873 25.473144872540434 -13.999999999999998 0.3360771769262422 7.340236498061725 0.3777865092285137 0.9997273128320558 0.004586993755039212 19.349591988251248 0.18572197445891608 86.98535757001315 0.016355566466979318 1.0000000000000041e-14 13.999999999999998 -6.962449988833211 QLNVNAKPFVPNVHAAEFVPSFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLNVNAKPFVPNVHAAEFVPSFLR 24 1 P15170-2;P15170-3 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 0 70734000.0 28250000.0 21760000.0 20724000.0 False True 27353219.213268194 30448881.476900943 15295762.693326565 1.0 1.1131735990377007 0.5591942423328026 24.705207298681266 -6.85348649202565 1.218181039067469 1.0606218074866374 0.5355166462374731 0.9452270853810077 0.0559303994090439 0.15365848911124777 0.4370502664053026 0.035892795643200984 0.08326304982186614 1.401243167493311e-07 6.85348649202565 -0.5251051612491643 QLNVNAKPFVPNVHAAEFVPSFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLNVNAKPFVPNVHAAEFVPSFLR 24 1 P15170-2;P15170-3 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 0 252870000.0 63245000.0 78325000.0 111300000.0 False True 95947288.82883713 64347291.79398183 89301506.21547712 1.0 0.6706525278559214 0.9307350661547552 26.51573870514545 -9.870408730949185 6.0112577638643065 1.000000032304017 0.8006937970052078 0.4391453571096109 0.10617825164046552 4.594074517176567e-08 8.664729889462728e-09 0.102806666934336 0.0342688833610106 1.3476939198727266e-10 9.870408730949185 -0.1993062352988092 QLNVNAKPFVPNVHAAEFVPSFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLNVNAKPFVPNVHAAEFVPSFLR 24 1 P15170-2;P15170-3 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 0 62194000.0 28250000.0 18805000.0 15139000.0 False True 23491126.687197275 18703693.732499734 18304494.905172758 1.0 0.7962024972898935 0.7792088965723707 24.485612574115542 -13.999999999999998 0.3519488496795524 3.536588873947644 0.7769212988157056 0.9997584017425333 0.001559254648794715 20.85588246853546 0.19111818165969935 39.587619197441455 0.00503687936386014 1.0000000000000041e-14 13.999999999999998 -2.7596675751319384 QLNVNAKPFVPNVHAAEFVPSFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLNVNAKPFVPNVHAAEFVPSFLR 24 1 P15170-2;P15170-3 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 0 170530000.0 63245000.0 67732000.0 39553000.0 False True 81871899.2453306 63962654.65878683 32354759.848051935 1.0 0.7812528504697516 0.39518760583653156 26.286865027237898 -6.962414761129153 0.39994871422933653 1.0212345048078095 0.14111039959121643 0.9998495400249848 0.0030670784806663565 0.07884953767421839 0.018024904411857758 0.0049675376265563 0.0323465606651871 1.0903984836258767e-07 6.962414761129153 -0.8801241052165931 down QLPNGDWPQENIAGVFNK(ub)SCAISYTSYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLPNGDWPQENIAGVFNKSCAISYTSYR 28 1 P48449;P48449-3;P48449-2;A0A0G2JQD0 P48449 LSS Lanosterol synthase 1 30875700.0 6925900.0 9715800.0 14234000.0 True False 8965714.079899363 9175107.189125396 11643558.053173488 1.0 1.0233548725020667 1.2986760395669659 23.09598706134176 -6.9236497175792415 0.7971721107993306 0.9946868141557795 1.3470311743514782 0.995136608238105 0.009458426235559444 0.09607127656922691 0.09482715181415359 0.008311145912474758 0.02583587728346702 1.1922031978950855e-07 6.9236497175792415 0.3523443601956987 QLQAETEPIVK(ub)MFEDPETTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLQAETEPIVKMFEDPETTR 20 1 P60228;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 9774100.0 3635300.0 0.0 6138800.0 True False 3519899.3913626154 0.0 4530864.119947558 1.0 0.0 1.287214097955675 21.747102762488858 -6.699348235811111 1.833264284928387 0.37864557657537634 1.2833319693255631 0.4144767263901591 0.4221623600337027 0.39686643365601004 2.5926840604421697 0.1837469642437123 0.4729169047297432 1.998258937951862e-07 6.699348235811111 0.9046863927501868 QLQAETEPIVK(ub)MFEDPETTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLQAETEPIVKMFEDPETTR 20 1 P60228;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 15441100.0 3635300.0 5203000.0 6602800.0 True False 3022913.021096222 5174970.406285354 7983414.952102159 1.0 1.7119150865970714 2.6409674695857017 21.527508037923134 -6.967468001839121 0.31281209985606473 0.8615426101406111 3.5209925202707364 0.9999553555091271 0.004489227414054193 0.07713315767227745 0.01195673622289065 0.014516492115668378 0.08226048251896172 1.0777846603134296e-07 6.967468001839121 2.6594499101301254 QLQAQDEEGGGHVPERPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLQAQDEEGGGHVPERPK 18 1 P33241;P33241-3;E7EMG9;C9JU59;C9JDV1 P33241 LSP1 Lymphocyte-specific protein 1 0 10217900.0 2424100.0 1366000.0 6427800.0 False True 2347148.272385257 1911450.923595896 4744166.350133394 1.0 0.8143716126009417 2.0212469770016703 21.162477550971463 -6.867655557872451 1.1465038979832651 0.8963769597229492 2.0888251271358347 0.9622826291167128 0.1030501418680381 0.13911837708314162 0.34325566924239204 0.06985341911638492 0.16473116001964416 1.356264649310876e-07 6.867655557872451 1.1924481674128855 up QLQDMQDVGK(ub)VDAAWEPSK ddPTM_RPMI8226_Bortezomib_1h_R1 2 QLQDMQDVGKVDAAWEPSK 19 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 228252600.0 46084600.0 69929000.0 112239000.0 True False 60417356.88390127 59495865.78110702 100625584.95251209 1.0 0.9847479077152449 1.6655078961146121 25.848459735170863 -6.901779399677961 0.9499852300068152 0.9730610774614731 1.739595287798481 0.9874297621101423 0.03558365642990469 0.11010679217940551 0.17014063897371445 0.027997061384017124 0.07351300180211158 1.2537778709622093e-07 6.901779399677961 0.766534210337008 QLQDMQDVGK(ub)VDAAWEPSK ddPTM_RPMI8226_Bortezomib_2h_R1 2 QLQDMQDVGKVDAAWEPSK 19 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 424453400.0 80805700.0 119611900.0 224035800.0 True False 78240567.28430386 167373555.43781826 165354103.05006605 1.0 2.1392170487418705 2.113406239108882 26.221413494819743 -10.338631200066764 5.747512472377864 0.9998219946122622 2.126311643925381 0.9996062899675269 0.01053721890817246 2.4038472901554734e-05 2.766108075607354e-06 0.01020417336240352 0.003400872778888698 4.585311029389552e-11 10.338631200066764 1.1264896493131187 QLQDMQDVGK(ub)VDAAWEPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLQDMQDVGKVDAAWEPSK 19 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 390521000.0 75789000.0 218880000.0 95852000.0 True False 114977453.91807632 179819153.8827545 76906810.18657589 1.0 1.5639514335643505 0.6688860082201289 26.776775748011875 -6.73638007743466 1.6997549574003985 1.3369407198614716 0.6687431195954909 0.5886915463989391 0.23697725532753888 0.3243931549772113 1.8387564627175428 0.11035463605927257 0.27190425545024 1.8349317803880244e-07 6.73638007743466 -0.6681976002659806 QLQDMQDVGK(ub)VDAAWEPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QLQDMQDVGKVDAAWEPSK 19 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 242399600.0 46084600.0 72177000.0 124138000.0 True False 63123322.00948739 68987981.48257887 94819161.10236232 1.0 1.0929079662855834 1.5021256499794333 25.911669796693754 -6.942668601455665 0.6342563525118476 0.9955330061340599 1.621716484759495 0.9984929064986704 0.008468038240092658 0.08657012226732501 0.04922300818534827 0.00842032815253251 0.034827639889383394 1.1411202138414602e-07 6.942668601455665 0.626183478625435 QLQDMQDVGK(ub)VDAAWEPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 QLQDMQDVGKVDAAWEPSK 19 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 359274000.0 80805700.0 173386300.0 105082000.0 True False 67193519.84947453 172452233.58741412 127054160.35572791 1.0 2.566500965773751 1.8908692481113043 26.00181877025402 -10.56326640912868 5.945186015080526 0.9968884405635223 2.228685106942521 0.8151436811570643 0.2758254937188577 0.011383790184290088 0.0008362532637831285 0.26725579772899954 0.08902229530271445 2.733591345794521e-11 10.56326640912868 1.2317966663789988 QLQDMQDVGK(ub)VDAAWEPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLQDMQDVGKVDAAWEPSK 19 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 358079000.0 75789000.0 214900000.0 67390000.0 True False 98110354.52453728 202940626.08771792 55125711.4797922 1.0 2.068493453837869 0.5618745518446305 26.547902070104325 -6.716202764376024 1.772849200735016 1.652680243635211 0.564688987249284 0.4945866873284276 0.44984854136668373 0.3627528037026205 2.226028107422669 0.20163465856605825 0.5084779344470041 1.9221940811202025e-07 6.716202764376024 -1.087991256385927 QLQEEDLK(ub)AQAQLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLQEEDLKAQAQLQK 15 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 6885100.0 2903200.0 1712800.0 2269100.0 True False 2811039.505131334 2396729.9721340043 1674754.6384591456 1.0 0.8526134078724117 0.5957776955471494 21.422672298195963 -6.962646883812713 0.39636909702675915 1.0146965981356566 0.424371223875041 0.9998561220914263 0.0020034693767943543 0.07876880933359581 0.0177343814767326 0.0033071562646270107 0.021548502032556406 1.0898158407317743e-07 6.962646883812713 -0.5903253742606156 QLQEEDLK(ub)AQAQLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLQEEDLKAQAQLQK 15 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 22577300.0 3075200.0 7086100.0 12416000.0 True False 4665303.227234415 5821530.091047995 9961972.157873886 1.0 1.2478353083383584 2.1353321901391884 22.153539423222274 -6.94741884299799 0.5864959997545933 0.9896295514246287 2.437927633614607 0.9989828535169207 0.015544602543237104 0.08453904850471988 0.04038151107781127 0.016174440297397924 0.07427338796282697 1.128706840287842e-07 6.94741884299799 1.4482980821899785 up QLQEEDLK(ub)AQAQLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLQEEDLKAQAQLQK 15 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 9111800.0 2903200.0 4421000.0 1787600.0 True False 2414139.433567119 4397183.195500212 2161378.895071457 1.0 1.821428843073475 0.8952999420906753 21.20307757363024 -6.67266604926478 1.9277988641056865 1.5231102222670936 0.898990756337607 0.29092285396977224 0.34871277576127696 0.4550512792955833 3.2628500805117406 0.14548812261976643 0.38737895740767747 2.1248777586780624e-07 6.67266604926478 -0.6241194659294865 QLQEEDLK(ub)AQAQLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLQEEDLKAQAQLQK 15 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 21358500.0 3075200.0 10410000.0 7873300.0 True False 3980907.0212545055 9830674.34887456 6440440.186880068 1.0 2.469455904492995 1.617832356418736 21.924665745314723 -9.949944714850442 5.77554156548295 0.9999991006796168 2.043644130456524 0.6669318142155631 0.34767385762241654 4.026124266020792e-06 7.321724788248465e-07 0.3366340560118996 0.11221125503993573 1.1221612949528055e-10 9.949944714850442 1.0436450297769069 QLQEFEK(ub)HEVHQYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLQEFEKHEVHQYR 14 1 Q9NRW4;Q9NRW4-2;S4R3M1 Q9NRW4 DUSP22 Dual specificity protein phosphatase 22 1 4677000.0 1713800.0 1558400.0 1404800.0 True False 2246808.3964628074 1325892.7945956204 1259444.7717931268 1.0 0.5901227700070012 0.5605483644158952 21.099445668804563 -13.999999999999998 0.3731506072009067 6.823610693786637 0.5576325684021041 0.9997962441834576 0.0028627418949857503 23.192258780573045 0.19856183806895233 108.18531971844611 0.00818478522537318 1.0000000000000041e-14 13.999999999999998 -6.2659781253845335 QLQEFEK(ub)HEVHQYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLQEFEKHEVHQYR 14 1 Q9NRW4;Q9NRW4-2;S4R3M1 Q9NRW4 DUSP22 Dual specificity protein phosphatase 22 1 23166400.0 1453800.0 7054600.0 14658000.0 True False 2205520.8870165786 5795651.512158625 11760839.875170358 1.0 2.62779262090709 5.332454543688007 21.072687992621024 -6.963501721748781 0.38289649279596066 0.8201612827939306 7.236171036059459 0.9998788516129848 0.01966725071158368 0.07847313026626784 0.01667578763071252 0.03510076943217945 0.22822969466084964 1.0876728255728194e-07 6.963501721748781 6.416009753265529 QLQEKIYAVEGTQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLQEKIYAVEGTQSR 15 1 Q13349 Q13349 ITGAD Integrin alpha-D 0 89926000.0 21913000.0 36967000.0 31046000.0 False True 28728155.20579387 31451667.696237374 27833657.7342607 1.0 1.0948029022724797 0.9688633862799249 24.77596201660495 -6.705239989583001 1.8116408215741333 1.0585601077222306 0.969191340508846 0.44280461783064506 0.039979969252077294 0.38467782996249883 2.45786694892229 0.017580017395931326 0.04493010520678816 1.9713330834368367e-07 6.705239989583001 -0.0893687672133846 QLQEKIYAVEGTQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLQEKIYAVEGTQSR 15 1 Q13349 Q13349 ITGAD Integrin alpha-D 0 54774000.0 21060000.0 19495000.0 14219000.0 False True 20391461.827661164 27279455.165081974 10494617.33914353 1.0 1.3377881093388408 0.5146574300478794 24.28146186751707 -6.795277232086655 1.4751686427870307 1.1875010272725646 0.5045822704315753 0.8179851168444854 0.14413192730912855 0.22756612279100102 0.9780927469991305 0.07688415820944644 0.17933894104270023 1.6022222848261147e-07 6.795277232086655 -0.6829187568409892 QLQEKIYAVEGTQSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLQEKIYAVEGTQSR 15 1 Q13349 Q13349 ITGAD Integrin alpha-D 0 139864000.0 24562000.0 31360000.0 83942000.0 False True 37262349.7227275 25763562.98320166 67350826.90691432 1.0 0.6914100472705198 1.8074766462146883 25.151215316119682 -6.8329523230957685 1.314571627100733 0.8354131306104345 1.8393815614868536 0.9116660856749198 0.13985560986136975 0.177197408496692 0.5978093144618652 0.08350313900732789 0.1921757554910169 1.4690875454119007e-07 6.8329523230957685 1.003968430876419 QLQEKIYAVEGTQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLQEKIYAVEGTQSR 15 1 Q13349 Q13349 ITGAD Integrin alpha-D 0 68861000.0 21913000.0 22454000.0 24494000.0 False True 30014828.276558693 21461908.034551512 18709021.669764824 1.0 0.7150435057232384 0.6233259606677943 24.83917207812784 -13.999999999842304 0.15857757631981634 2.399234425931865 0.5317329024239696 0.9995401810697471 0.003439085462092026 12.000514484649855 0.12579328541862278 5.16534724506171 0.08333241444957662 1.0000000003631086e-14 13.999999999842304 -1.8675015235078956 QLQEKIYAVEGTQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLQEKIYAVEGTQSR 15 1 Q13349 Q13349 ITGAD Integrin alpha-D 0 58459000.0 21060000.0 16332000.0 21067000.0 False True 17512323.116190244 16244016.27435181 25472012.2971976 1.0 0.9275763224888263 1.4545193192357544 24.061867142951346 -6.872165045822871 1.1225149289638117 0.9584467560343093 1.4866853176600399 0.9667998010973549 0.042493870013225854 0.1347991801810482 0.3161250621118346 0.029337721996698363 0.06973492038244486 1.3422547643668337e-07 6.872165045822871 0.5282385616257306 QLQEKIYAVEGTQSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLQEKIYAVEGTQSR 15 1 Q13349 Q13349 ITGAD Integrin alpha-D 0 100488000.0 24562000.0 24840000.0 51086000.0 False True 31795993.189403318 23457632.16388508 41788872.18662507 1.0 0.7377543460948667 1.3142810774205378 24.92234163821213 -6.783039979184055 1.5240746827924747 0.8520957574400223 1.319286930114449 0.7779815790055535 0.11105220242344191 0.24588098836273223 1.1282661473831839 0.057379905227877566 0.13504982967306695 1.6480106761398102e-07 6.783039979184055 0.46719117267442667 QLQGFPFYGKPMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLQGFPFYGKPMR 13 1 P08579 P08579 SNRPB2 U2 small nuclear ribonucleoprotein B 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 QLQQAQAAGAEQEVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLQQAQAAGAEQEVEK 16 0 P39748;P39748-2;F5H1Y3 P39748 FEN1 Flap endonuclease 1 0 11389200.0 2482300.0 1083500.0 7823400.0 False True 2403500.7452423205 1516147.2003778545 5774216.843030836 1.0 0.6308078761277841 2.40241941029591 21.196705820129807 -6.852336082993185 1.2238756738659584 0.8025334646774429 2.476452109493627 0.9436207499105571 0.18120662753208866 0.1549079992384332 0.44535179180409784 0.1157872178391316 0.2683509930198042 1.4049598615320017e-07 6.852336082993185 1.6739186448161842 up QLSAQGQMTQLCELINK(ub)SGELLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLSAQGQMTQLCELINKSGELLAK 24 1 Q9UNS2;C9JLV5;J3KTQ1;J3QKR0 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 57021000.0 21019000.0 20722000.0 15280000.0 True False 31887359.69473204 17023997.19827501 12259901.302538073 1.0 0.5338791722253337 0.38447527233066814 24.926481310155015 -13.999999999999998 0.15918089313694833 3.2916502259279548 0.23626835147567407 0.9995385461010342 0.005631171842983608 12.004309414635628 0.12605362285050598 8.494107951585663 0.1349396510404219 1.0000000000000041e-14 13.999999999999998 -3.0553818744522805 QLSAQGQMTQLCELINK(ub)SGELLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLSAQGQMTQLCELINKSGELLAK 24 1 Q9UNS2;C9JLV5;J3KTQ1;J3QKR0 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 49500300.0 21019000.0 18504000.0 9977300.0 True False 27209509.846432194 17474236.133676715 8161533.775743146 1.0 0.6422106179897981 0.299951517752655 24.697607632247465 -7.45815962624415 0.28325836556508005 1.0986279777264716 1.1093525990101792e-21 0.9998004616221593 0.0040373917228982755 0.12190656344949505 0.02682511465353994 0.021632627277742275 0.06175400018043166 3.482093061337644e-08 7.45815962624415 -1.0986279777264716 down QLSAQSYGVTSSTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLSAQSYGVTSSTAR 15 0 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 2895400.0 0.0 1150400.0 1745000.0 False True 0.0 978764.8042240781 1564444.1392219611 0.0 QLSAQSYGVTSSTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLSAQSYGVTSSTAR 15 0 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 2841200.0 0.0 1413800.0 1427400.0 False True 0.0 1351333.6411886062 1090277.5182257812 0.0 QLSDAISIIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLSDAISIIGR 11 0 P55060-3;P55060;P55060-4;P55060-2 P55060-3 CSE1L Exportin-2 0 5561750.0 719250.0 1751000.0 3091500.0 False True 942943.715226908 1489757.6253445416 2771621.2357620005 1.0 1.5799009010692113 2.9393283936306247 19.846812132732246 -6.956825502817155 0.4780840545377068 0.9667742224102699 3.6089493422167003 0.9996337170185631 0.015555171537020865 0.08085532737099889 0.025474647961604795 0.01909366083327815 0.11214944255193653 1.1045223218753224e-07 6.956825502817155 2.6421751198064305 QLSDAISIIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLSDAISIIGR 11 0 P55060-3;P55060;P55060-4;P55060-2 P55060-3 CSE1L Exportin-2 0 5328050.0 719250.0 2191600.0 2417200.0 False True 985176.1620004033 2094767.8653479633 1846307.1437966651 1.0 2.126287608395366 1.8740883255312764 19.910022194255138 -10.069885847618526 4.502280484118105 0.9999361155932965 2.000187966974114 0.9544849728820629 0.10295992628305363 7937304.618237155 8876366.625113461 4108.45917142964 0.035245921244001874 8.513617854710053e-11 10.069885847618526 1.0002518513808174 QLSDAISIIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLSDAISIIGR 11 0 P55060-3;P55060;P55060-4;P55060-2 P55060-3 CSE1L Exportin-2 0 2791970.0 1540700.0 573480.0 677790.0 False True 1281160.3145828273 570390.5494131319 819512.7552531228 1.0 0.44521403209313665 0.6396644868913016 20.289019584100068 -10.363208016059586 6.281356015400962 1.000045764700635 0.5424392594922219 0.880707442313811 0.0793840657512718 5.0881928682567055e-05 5.1583782984145314e-06 0.07687094519104835 0.025621097050742482 4.333032873735728e-11 10.363208016059586 -0.4576065052084132 QLSESQVK(ub)SLCEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLSESQVKSLCEK 13 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 44915000.0 16645000.0 17289000.0 10981000.0 True False 21821756.19040928 14709548.59199418 9844791.457189878 1.0 0.6740772128349168 0.4511456993327004 24.379263877020584 -8.097875945481416 0.14682209245312997 1.374626909350364 5.727415708512768e-15 0.9999461858185993 0.0016533356587246219 0.09328976678338577 0.026956211048296565 0.1064471838721521 0.12091795234399892 7.982226638851771e-09 8.097875945481416 -1.3746269093503583 down QLSESQVK(ub)SLCEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLSESQVKSLCEK 13 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 117385000.0 36032000.0 34592000.0 46761000.0 True False 54663178.29204937 28418787.33147039 37518667.85392562 1.0 0.5198890408391024 0.686360892765407 25.704066009416113 -10.325909669712825 10.117615274181563 1.00000006004366 0.6031249668022547 0.8834250968831494 0.06796184895926721 9.201667241518136e-08 6.20258724177614e-09 0.06580378710457509 0.02193459243305882 4.721612373649604e-11 10.325909669712825 -0.39687509324140535 QLSESQVK(ub)SLCEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLSESQVKSLCEK 13 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 110842000.0 36032000.0 32886000.0 41924000.0 True False 46644134.296904966 31055865.190882668 34294262.17656632 1.0 0.6658043001334758 0.7352320435035254 25.475192331508563 -10.840345649646334 7.315724324809593 1.0203415134022062 0.7005181718185006 0.9612541959546166 0.028343757541586568 0.008988804548845371 0.0001961665372895935 0.026232829830928624 0.00914790841062547 1.4442898206542677e-11 10.840345649646334 -0.3198233415837056 QLSEVFIQLPSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLSEVFIQLPSR 12 0 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8YG32;A0A2R8Y7F3;A0A2R8Y6N0;A0A2R8YF80;A0A2R8YF58;A0A2R8Y526;A0A2R8Y7Y7;A0A2R8Y6V2;A0A2R8Y523;A0A2R8Y5K3;K7EQF0;A0A2R8YFK5;K7EP28;A0A0U1RRF5;P51531;P51531-2;F6VDE0;A0A0U1RRG6;A0A1W2PS06;A0A0U1RQX3;B1ALF6;B4DNT1;A0A0U1RR26;B1ALG2;F6T8Q0;A0A0U1RR83;A0A0U1RRD6;B1ALG1;A0A0U1RRN2;A0A0U1RQW7;F6XE55;A0A0U1RR09;A0A0U1RQU0;F6UH26;A0A0A0MSS5;A0A0U1RRF8 P51532;P51531 SMARCA4;SMARCA2 Transcription activator BRG1;Probable global transcription activator SNF2L2 0 8802400.0 2594000.0 3723900.0 2484500.0 False True 3400759.1203317377 3168308.6356485086 2227427.7730068527 1.0 0.9316474715031996 0.6549795778507157 21.69742539124466 -6.944603018696147 0.6152566121400675 1.0030404658026366 0.569048139460594 0.9987067124000458 0.005364374958954918 0.0857281634025063 0.04550934165422852 0.005425962924191049 0.02337330245578187 1.1360487843501799e-07 6.944603018696147 -0.43399232634204266 QLSEVFIQLPSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLSEVFIQLPSR 12 0 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8YG32;A0A2R8Y7F3;A0A2R8Y6N0;A0A2R8YF80;A0A2R8YF58;A0A2R8Y526;A0A2R8Y7Y7;A0A2R8Y6V2;A0A2R8Y523;A0A2R8Y5K3;K7EQF0;A0A2R8YFK5;K7EP28;A0A0U1RRF5;P51531;P51531-2;F6VDE0;A0A0U1RRG6;A0A1W2PS06;A0A0U1RQX3;B1ALF6;B4DNT1;A0A0U1RR26;B1ALG2;F6T8Q0;A0A0U1RR83;A0A0U1RRD6;B1ALG1;A0A0U1RRN2;A0A0U1RQW7;F6XE55;A0A0U1RR09;A0A0U1RQU0;F6UH26;A0A0A0MSS5;A0A0U1RRF8 P51532;P51531 SMARCA4;SMARCA2 Transcription activator BRG1;Probable global transcription activator SNF2L2 0 6068900.0 1801300.0 1176900.0 3090700.0 False True 1744118.717481771 1646842.3074524212 2281152.9509874717 1.0 0.9442260385979909 1.307911513203122 20.734066813162084 -6.8677795804634485 1.1458374097636201 0.9688451236984574 1.328325465228099 0.9624132255789571 0.03100537597661208 0.13899838676758858 0.34248309880056327 0.021027829381139007 0.0495990373446939 1.3558773926279985e-07 6.8677795804634485 0.3594803415296415 QLSEVFIQLPSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLSEVFIQLPSR 12 0 P51532;P51532-4;P51532-3;P51532-2;P51532-5;A0A0A0MT49;Q9HBD4;A0A2R8Y4P4;A0A2R8Y7S2;A0A2R8YGG3;A0A2R8Y440;A0A2R8YG32;A0A2R8Y7F3;A0A2R8Y6N0;A0A2R8YF80;A0A2R8YF58;A0A2R8Y526;A0A2R8Y7Y7;A0A2R8Y6V2;A0A2R8Y523;A0A2R8Y5K3;K7EQF0;A0A2R8YFK5;K7EP28;A0A0U1RRF5;P51531;P51531-2;F6VDE0;A0A0U1RRG6;A0A1W2PS06;A0A0U1RQX3;B1ALF6;B4DNT1;A0A0U1RR26;B1ALG2;F6T8Q0;A0A0U1RR83;A0A0U1RRD6;B1ALG1;A0A0U1RRN2;A0A0U1RQW7;F6XE55;A0A0U1RR09;A0A0U1RQU0;F6UH26;A0A0A0MSS5;A0A0U1RRF8 P51532;P51531 SMARCA4;SMARCA2 Transcription activator BRG1;Probable global transcription activator SNF2L2 0 8550000.0 2594000.0 2500400.0 3455600.0 False True 3553071.9002141804 2389924.0602829154 2639458.4503159695 1.0 0.6726359970758965 0.7428666023214622 21.760635452767552 -10.096580102391625 5.122116111740506 1.000006891770076 0.7077512996980554 0.9584859890637383 0.02867152453192109 2.2565522975717957e-06 3.9797357703995906e-07 0.027761738920756774 0.0092536947515631 8.006079486979799e-11 10.096580102391625 -0.29225559207202056 QLSILVHPDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLSILVHPDK 10 0 O75937 O75937 DNAJC8 DnaJ homolog subfamily C member 8 0 34600000.0 9468100.0 8987900.0 16144000.0 False True 12412770.789210835 7646940.354559802 14473573.74418299 1.0 0.6160542625347205 1.166022799419079 23.565321855237315 -6.719003459562552 1.7627027313089665 0.7661594246609905 1.165126635238757 0.5078094685844368 0.161586944904098 0.35730380327322814 2.1690853766326565 0.07279899268219779 0.18298094528061135 1.909838044855789e-07 6.719003459562552 0.3989672105777665 QLSILVHPDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLSILVHPDK 10 0 O75937 O75937 DNAJC8 DnaJ homolog subfamily C member 8 0 8803500.0 0.0 0.0 8803500.0 False True 0.0 0.0 6497599.250661083 0.0 QLSILVHPDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLSILVHPDK 10 0 O75937 O75937 DNAJC8 DnaJ homolog subfamily C member 8 0 35482600.0 9468100.0 7750500.0 18264000.0 False True 12968712.43578175 7408057.282523894 13950419.358887278 1.0 0.5712253486386552 1.075698102488333 23.628531916760206 -6.681546801449764 1.8962888302414536 0.7290789624999394 1.0738029685948491 0.33114069651301437 0.18166538065401583 0.43516812489108386 3.026729952535085 0.07683154872628925 0.20224501852976087 2.0818680420361194e-07 6.681546801449764 0.3447240060949097 QLSILVHPDKNQDDADR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLSILVHPDKNQDDADR 17 1 O75937 O75937 DNAJC8 DnaJ homolog subfamily C member 8 0 8841800.0 2819200.0 2461400.0 3561200.0 False True 3695998.5011716345 2094168.7144620528 3192721.185442542 1.0 0.5666043191841662 0.863831839875056 21.81753274102601 -10.100756095400522 5.426223692490807 1.0000037584937636 0.7152180795294794 0.5503620535403646 0.12134262720133193 5.517391904134418e-06 9.143927279693304e-07 0.11749104448000629 0.039163164527917335 7.929465330240121e-11 10.100756095400522 -0.2847856789642842 QLSILVHPDKNQDDADR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLSILVHPDKNQDDADR 17 1 O75937 O75937 DNAJC8 DnaJ homolog subfamily C member 8 0 32368300.0 5585800.0 20606000.0 6176500.0 False True 8474066.976679878 16928698.30458716 4955712.067743878 1.0 1.9977064556102657 0.5848091691252498 23.014623100733324 -6.717049823240784 1.7707161440694263 1.6089207498122182 0.5874788801626798 0.49824941630351716 0.41999724300556407 0.36105614176166806 2.210954889287489 0.18848466436823763 0.47467636866069135 1.918448639297953e-07 6.717049823240784 -1.0214418696495384 QLSILVHPDKNQDDADR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLSILVHPDKNQDDADR 17 1 O75937 O75937 DNAJC8 DnaJ homolog subfamily C member 8 0 12113700.0 2819200.0 4569300.0 4725200.0 False True 3861534.4260153435 4367413.21734552 3609205.0785487317 1.0 1.1310046047814688 0.9346556783835315 21.8807428025489 -6.7268985875577005 1.7347354716099133 1.0791109768515665 0.9348416790098427 0.5447151184667562 0.0550860517464864 0.34209652692785175 2.0154012432734745 0.02518042787919464 0.06269942392253683 1.8754323906166812e-07 6.7268985875577005 -0.14426929784172382 QLSILVHPDKNQDDADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLSILVHPDKNQDDADR 17 1 O75937 O75937 DNAJC8 DnaJ homolog subfamily C member 8 0 19560000.0 5585800.0 7713000.0 6261200.0 False True 7230928.212579145 7283764.7697280925 5121725.845337211 1.0 1.007307022777108 0.7083082136574527 22.785749422825774 -6.901297772100955 0.9530130528020775 1.0119924971823122 0.6760812034917696 0.9872013673859775 0.015754521785232442 0.11045677847198691 0.17207526955240526 0.012367461151491177 0.0323931863577514 1.2551690674444233e-07 6.901297772100955 -0.3359112936905426 QLSQATAAATNHTTDNGVGPEEESVDPNQYYK(ub)IR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLSQATAAATNHTTDNGVGPEEESVDPNQYYKIR 34 1 Q15046;Q15046-2;H3BVA8 Q15046 KARS Lysine--tRNA ligase 1 29294700.0 7964600.0 5686100.0 15644000.0 True False 12082880.490254672 4671371.029297926 12551956.542991208 1.0 0.38661071199583363 1.038821542025088 23.526461090200886 -11.809623391130877 17.728943557758992 0.9212846099558727 0.7414445143103833 0.0 0.3061541349590792 0.0 0.0 0.0 0.08879485746125404 1.5501602948817102e-12 11.809623391130877 -0.17984009564548942 QLSQATAAATNHTTDNGVGPEEESVDPNQYYK(ub)IR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLSQATAAATNHTTDNGVGPEEESVDPNQYYKIR 34 1 Q15046;Q15046-2;H3BVA8 Q15046 KARS Lysine--tRNA ligase 1 29948500.0 7964600.0 9150900.0 12833000.0 True False 10310331.705737378 8641644.370712403 10497525.677699551 1.0 0.838153865205287 1.01815596018681 23.297587412293336 -6.669800927529353 1.9383158191838668 0.8966736734727823 1.0174234189501337 0.2780249263364679 0.06875242756593908 0.4615988125103859 3.3433707655670584 0.028558964376050325 0.07631562335714961 2.1389423159928874e-07 6.669800927529353 0.1207497454773514 QLSVSLLCYNFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLSVSLLCYNFLR 13 0 Q9NYH9 Q9NYH9 UTP6 U3 small nucleolar RNA-associated protein 6 homolog 0 21562300.0 5461300.0 9227600.0 6873400.0 False True 8285191.3745107 7580862.684432125 5514869.477281763 1.0 0.9149894482527664 0.6656297034065137 22.982103591076132 -6.951955083980446 0.5369500128321775 1.0037466927537897 0.5654169986133397 0.9993459204472361 0.003628985621361703 0.08271002949031998 0.03278569717014063 0.004008404323278791 0.020640771954168986 1.1169787630536438e-07 6.951955083980446 -0.43832969414045 QLSVSLLCYNFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLSVSLLCYNFLR 13 0 Q9NYH9 Q9NYH9 UTP6 U3 small nucleolar RNA-associated protein 6 homolog 0 14049600.0 5461300.0 3437500.0 5150800.0 False True 7069760.508317256 3246200.103194644 4213407.251671075 1.0 0.4591669122844593 0.5959759523274077 22.753229913168582 -10.223834838255486 8.205761147393691 1.0000002019808623 0.5275714323060241 0.9408263923135698 0.055852056717535875 2.0634840315136182e-07 1.9542472028404445e-08 0.05407854474797366 0.018026173793204044 5.972623816681622e-11 10.223834838255486 -0.47242876967483816 QLTANTGHTIHVHYPGNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLTANTGHTIHVHYPGNR 18 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 9490600.0 2949200.0 3064100.0 3477300.0 False True 3866429.760093431 2606948.223768252 3117502.3526169145 1.0 0.674252058236086 0.8063000095834099 21.88257057373741 -10.058560313647138 4.959863614579954 1.0000055603173135 0.7402760342919263 0.8376152855566896 0.05390835040333562 3.3146081036368183e-06 6.29253581845644e-07 0.05219765292546496 0.017398845276868895 8.738556254491623e-11 10.058560313647138 -0.2597295260253871 QLTANTGHTIHVHYPGNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLTANTGHTIHVHYPGNR 18 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 7532500.0 2949200.0 2238000.0 2345300.0 False True 4039598.939133254 2139117.7599236793 1791388.4429696836 1.0 0.5295371625141216 0.44345700401487087 21.945780635260302 -13.999999999999998 0.238866213101391 4.096994750125547 0.4049850934543243 0.999523100305106 0.005341692604368892 13.583672774746868 0.1546929387595173 20.053470157856065 0.04234411883647594 1.0000000000000041e-14 13.999999999999998 -3.692009656671223 QLTDCISEFLK(ub)EEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLTDCISEFLKEEK 14 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;Q86UV5-7;Q86UV5-4 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 12349800.0 1941400.0 6149900.0 4258500.0 True False 2545194.2005443457 5232358.892122448 3817871.270416457 1.0 2.0557798265465927 1.5000314198421172 21.27934430871878 -10.223700330758202 4.9243627451682945 0.9998830108167638 1.7779056231953847 0.7231740825888247 0.22688333696867918 0.00029145048899815025 4.594529652066662e-05 0.21971148800869458 0.07322628213379669 5.974473914103641e-11 10.223700330758202 0.7780226123786209 QLTDCISEFLK(ub)EEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLTDCISEFLKEEK 14 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;Q86UV5-7;Q86UV5-4 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 11285900.0 5577800.0 2668900.0 3039200.0 True False 5400735.792133363 3734605.6881296397 2243142.345954356 1.0 0.6914994237580395 0.4153401373978868 22.364724541664735 -7.181401782727302 0.21081954678316184 1.156548467876105 1.870495855978851e-14 0.9999862917031471 0.0008841613308649088 0.08790811225075626 0.00961121111265977 0.012631400474299356 0.036148159065165254 6.585643498203387e-08 7.181401782727302 -1.1565484678760865 down QLTDCISEFLK(ub)EEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLTDCISEFLKEEK 14 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;Q86UV5-7;Q86UV5-4 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 33132000.0 10243000.0 12156000.0 10733000.0 True False 15539379.863606304 9986666.824738491 8611617.845558984 1.0 0.6426682990180044 0.554180277536535 23.889425594884344 -13.999999999999988 0.19602820272802593 2.9571004213033225 0.4944096693819439 0.9994872067419963 0.004364143912935732 12.455163000145399 0.14040182866973863 9.331217270943666 0.058060032837112134 1.0000000000000286e-14 13.999999999999988 -2.4626907519213788 QLTDCISEFLK(ub)EEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLTDCISEFLKEEK 14 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;Q86UV5-7;Q86UV5-4 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 10850300.0 1941400.0 3257600.0 5651300.0 True False 2659188.0443623 3113668.460557362 4316579.332176937 1.0 1.1709094688352704 1.623269682386112 21.342554370241672 -6.954227692179788 0.5103249423831125 0.9916968844590371 1.8223389939770085 0.9994926508941756 0.005922889102881548 0.08183122413360683 0.02927059014844895 0.006818188525152743 0.03733518232640278 1.1111490206477278e-07 6.954227692179788 0.8306421095179713 QLTDCISEFLK(ub)EEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLTDCISEFLKEEK 14 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;Q86UV5-7;Q86UV5-4 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 15909900.0 5577800.0 1997300.0 8334800.0 True False 4638187.838437137 1986540.1484669924 10077568.144238967 1.0 0.42830092649640683 2.1727382536612962 22.14512981709901 -6.818425471569016 1.3787829304607744 0.6913723098135716 2.2095211792672407 0.8807182783947749 0.25078046729123865 0.19552196878041317 0.7308014597688749 0.14295105371564448 0.3296079422568527 1.5190586023564145e-07 6.818425471569016 1.5181488694536691 up QLTDCISEFLK(ub)EEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLTDCISEFLKEEK 14 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;Q86UV5-7;Q86UV5-4 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 27276300.0 10243000.0 8809800.0 8223500.0 True False 13259765.419715757 8319526.8855634155 6726907.380235505 1.0 0.6274264002584261 0.5073172237446495 23.660551916976793 -13.999999999999998 0.15834745510022327 2.828610069847688 0.3870643011702097 0.9995408124417012 0.004494760649153237 11.999110672794956 0.12569388455417477 6.739992444106287 0.1093772114282719 1.0000000000000041e-14 13.999999999999998 -2.441545768677478 QLTLNGIYTHITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLTLNGIYTHITK 13 0 E9PM37;E9PPI7;Q01167-3;Q01167-2;Q01167 E9PM37 FOXK2 Forkhead box protein K2 0 8756900.0 2688300.0 2351800.0 3716800.0 False True 3524387.333534235 2000920.6072446003 3332221.1900631366 1.0 0.5677357276273288 0.9454753052700381 21.7489410558587 -10.205399951659837 7.811342132346586 1.000000151153391 0.7566055164486835 0.356322657731725 0.1542115368131777 4.0584122130497773e-07 4.130146810747152e-08 0.149314769689999 0.04977155948920745 6.231606883081879e-11 10.205399951659837 -0.24339463470470746 QLTLNGIYTHITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLTLNGIYTHITK 13 0 E9PM37;E9PPI7;Q01167-3;Q01167-2;Q01167 E9PM37 FOXK2 Forkhead box protein K2 0 9538700.0 2688300.0 3372700.0 3477700.0 False True 3682237.1585758585 3223682.961972566 2656338.8854797534 1.0 0.8754685869335361 0.7213926673063933 21.812151117381593 -6.968259848938431 0.29682662328123866 1.0277499648970942 0.5643051495303968 0.9999654446083002 0.0006698400825749634 0.0768715190858387 0.01104070481259621 0.0025972747802397718 0.01386557289652964 1.075821330987482e-07 6.968259848938431 -0.46344481536669746 QLTLSGIYAHITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLTLSGIYAHITK 13 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 0 17498800.0 3704900.0 6839000.0 6954900.0 False True 4857159.778302637 5818647.8582132 6235273.664111631 1.0 1.197952738595427 1.2837283409874947 22.211681514523246 -13.999999999970546 0.11390248485141802 0.05057637154514052 1.4325955796314875 0.9997233052774486 0.0019763109890100893 11.991147898517575 0.10302925364687752 2.600366058403882 0.1321275597090277 1.0000000000678198e-14 13.999999999970546 1.382019208086347 QLTLSGIYAHITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLTLSGIYAHITK 13 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 0 19468600.0 7692600.0 3562700.0 8213300.0 False True 7448402.623716348 4985304.689235061 6061990.336281557 1.0 0.6693119237890588 0.8138644810874835 22.828499629269665 -10.136506257883562 5.034867769156232 1.0000116074153744 0.7415882024377395 0.8099221793390534 0.059013334401107495 7.689466129063874e-06 1.3186647167483941e-06 0.05714198146344605 0.01904647177804047 7.302872898620373e-11 10.136506257883562 -0.25842340497763494 QLTLSGIYAHITK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLTLSGIYAHITK 13 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 0 10812300.0 3816800.0 0.0 6995500.0 False True 5790364.645456657 0.0 5612836.358763435 1.0 0.0 0.9693407414621948 22.465222773432828 -11.907512494826225 13.764655088537197 0.8594111740207349 0.5362033336579991 0.0 0.47966285964732436 0.0 0.0 0.0 0.13662011169141045 1.2373355907826242e-12 11.907512494826225 -0.32320784036273575 QLTLSGIYAHITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLTLSGIYAHITK 13 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 0 20700000.0 3704900.0 4114100.0 12881000.0 False True 5074701.651157864 3932325.4584906213 9838773.092522284 1.0 0.7748880089518969 1.9387884783881688 22.274891576046137 -6.856574652087319 1.2030356336959873 0.8788175449427257 1.9915396315485707 0.9493223597784982 0.11347183243696612 0.1503767477483782 0.41554026149953244 0.0736638949619374 0.17133123686498125 1.3913146173466257e-07 6.856574652087319 1.112722086605845 QLTLSGIYAHITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLTLSGIYAHITK 13 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 0 16135600.0 7692600.0 3348900.0 5094100.0 False True 6396737.739962255 3330858.8109953944 6159252.75754281 1.0 0.520712110829019 0.9628740473545121 22.60890490470394 -10.491445495505403 9.042043474588924 1.0000065102241227 0.7417930790917656 0.31256652429361853 0.18051185469472364 2.3690852497961528e-05 1.332515931044921e-06 0.17478425530698893 0.05825995058547316 3.2251840585063355e-11 10.491445495505403 -0.25821343113235706 QLTLSGIYAHITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLTLSGIYAHITK 13 0 P85037;P85037-2 P85037 FOXK1 Forkhead box protein K1 0 19299400.0 3816800.0 9361100.0 6121500.0 False True 4940922.840375973 8840146.555931762 5007449.811894171 1.0 1.7891691170913089 1.0134644829857606 22.236349095525277 -10.257734203406722 4.853727332292865 0.9998998314110727 1.4013168000390575 0.2630144541961257 0.31668009078028986 0.00034334985855398047 5.2507810229730216e-05 0.3067003196234229 0.1022080598053695 5.524154247302894e-11 10.257734203406722 0.4014169686279847 QLTPPEGSSK(ub)SEQDQAENEGEDSAVLMER ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLTPPEGSSKSEQDQAENEGEDSAVLMER 29 1 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 13129500.0 3424300.0 4574700.0 5130500.0 True False 4489290.460968368 3892172.5920409337 4599645.075231094 1.0 0.8669905914711894 1.0245817496600391 22.098056012212073 -6.682967567091273 1.89147109144344 0.9160687040213025 1.0239949468717295 0.33773499366020954 0.0563362707132306 0.4319441353553576 2.9903150960913107 0.0238778166855328 0.06273479576156776 2.0750684768117334e-07 6.682967567091273 0.10792624285042707 QLTPPEGSSK(ub)SEQDQAENEGEDSAVLMER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLTPPEGSSKSEQDQAENEGEDSAVLMER 29 1 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 12886600.0 3424300.0 4958200.0 4504100.0 True False 4690356.248227985 4739130.329425192 3440324.344851295 1.0 1.0103988009899323 0.7334889212628676 22.161266073734964 -6.898175361794542 0.9727476294341275 1.012096363375798 0.7054776824435605 0.9856359516917261 0.015359495229271103 0.11276029407672186 0.18509873719248998 0.011882094766040227 0.030641113724250157 1.2642257684200402e-07 6.898175361794542 -0.30661868093223754 QLTVQMMQNPQILAALQER ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLTVQMMQNPQILAALQER 19 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8W020;F8VUX1;F8VXI6;F8VVB5 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 27172500.0 12426000.0 7617200.0 7129300.0 False True 12031543.431648502 10658787.68317323 5261922.455584492 1.0 0.8859036036171143 0.4373439272756321 23.520318390545658 -6.945272532387237 0.6085411057522401 1.0049723523229552 0.2949741755811572 0.9987760763739595 0.008496177233102059 0.08544152966421535 0.044260456687741 0.008648137476236542 0.03780437643773934 1.134298786889035e-07 6.945272532387237 -0.709998176741798 down QLTVQMMQNPQILAALQER ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLTVQMMQNPQILAALQER 19 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8W020;F8VUX1;F8VXI6;F8VVB5 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 85005000.0 16005000.0 47182000.0 21818000.0 False True 24280755.122231655 38762003.46535146 17505662.736830886 1.0 1.5964084836002757 0.7209686292170774 24.53330995376883 -6.723281581380314 1.7474328429429007 1.3615748045178564 0.7220714840470573 0.5279414193434093 0.250876191982385 0.34900589009746974 2.0844068959524784 0.11391664728285311 0.28488358524102414 1.891117086769871e-07 6.723281581380314 -0.639503320470799 QLTVQMMQNPQILAALQER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLTVQMMQNPQILAALQER 19 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8W020;F8VUX1;F8VXI6;F8VVB5 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 2211400.0 2211400.0 0.0 0.0 False True 3029014.340837944 0.0 0.0 1.0 0.0 0.0 21.530416977898795 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 QLTVQMMQNPQILAALQER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLTVQMMQNPQILAALQER 19 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8W020;F8VUX1;F8VXI6;F8VVB5 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 23995700.0 12426000.0 5684600.0 5885100.0 False True 10332769.565136744 5653975.93149525 7115647.20037203 1.0 0.5471888147561167 0.6886485908270482 23.300723665979934 -10.851652463859892 10.842056547678501 1.009413766114883 0.6179187027915846 0.9067783503926867 0.057750711750358674 0.01276048635139452 0.00017459627255927233 0.054296974336770644 0.01863896207006366 1.4071731380149146e-11 10.851652463859892 -0.3914950633232984 QLTVQMMQNPQILAALQER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLTVQMMQNPQILAALQER 19 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8W020;F8VUX1;F8VXI6;F8VVB5 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 40444000.0 16005000.0 13858000.0 10581000.0 False True 20718788.00571616 13086790.11783897 8655366.570228228 1.0 0.631638786700671 0.4177544829282619 24.304436275861278 -9.51424944967198 0.1311173276412486 1.6381159454659477 1.5992929370498256e-09 0.9998650886264961 0.0027931230637538405 0.9681484677790393 0.05192698999194857 0.42982129028613486 0.20642888491866393 3.060205210892734e-10 9.51424944967198 -1.6381159438666548 QLVAEQVTYQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLVAEQVTYQR 11 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 9130300.0 1324600.0 4420900.0 3384800.0 False True 1736563.4274446468 3761318.9525332293 3034573.3652942595 1.0 2.165955411181272 1.7474589855664726 20.727803674998803 -10.06301221291183 4.729213836099121 0.9999652707685592 1.9567071983953446 0.8744992987254362 0.1708504503914171 118491150.32091643 4.598906533945031 45735.68352900776 0.0584866535141908 8.64943595122423e-11 10.06301221291183 0.9567419276267853 QLVAEQVTYQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLVAEQVTYQR 11 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 5612800.0 1324600.0 2096400.0 2191800.0 False True 1814340.415969043 2003774.1161322617 1674141.9815379505 1.0 1.1044091276895476 0.9227276021648825 20.791013736521695 -6.750848244308871 1.6465869281460201 1.0613306043715596 0.9223404202513331 0.6526593595086192 0.04387547132697165 0.29856910367913175 1.5929176669531986 0.021046650787732952 0.05105253087061429 1.7748095449445606e-07 6.750848244308871 -0.13899018412022646 QLVEQVEQIQK(ub)EQNYQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLVEQVEQIQKEQNYQR 17 1 Q9BVK6 Q9BVK6 TMED9 Transmembrane emp24 domain-containing protein 9 1 45130200.0 5164200.0 4134000.0 35832000.0 True False 5000265.297740161 5784727.758525203 26446524.26304176 1.0 1.1568841679539632 5.28902421937374 22.253573210927605 -6.914921987638941 0.8615498119013388 0.8911045101073352 5.883303439717221 0.9926501035954328 0.17025601806241633 0.10125225212570996 0.12177997904147242 0.14287658539351494 0.4092409699874979 1.2164044838813446e-07 6.914921987638941 4.992198929609885 up QLVEQVEQIQK(ub)EQNYQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLVEQVEQIQKEQNYQR 17 1 Q9BVK6 Q9BVK6 TMED9 Transmembrane emp24 domain-containing protein 9 1 42181500.0 5164200.0 5633300.0 31384000.0 True False 4294261.112850413 5602952.294777503 37946249.296779305 1.0 1.304753518133977 8.83650255528864 22.03397848636188 -6.915419130863583 0.8580041386731386 0.8048342322034366 9.931745357116627 0.9928111000290153 0.307309117891105 0.10094292796373644 0.12013263208780818 0.25854425419179794 0.7435789923572297 1.2150128446025748e-07 6.915419130863583 9.12691112491319 up QLVESK(ub)YTVENGYSTSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLVESKYTVENGYSTSAK 18 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 10204100.0 2171000.0 4124100.0 3909000.0 True False 2846202.0239939033 3508800.355615894 3504534.1777757234 1.0 1.2328008785167703 1.2313019765399584 21.440606637608102 -10.033244153673182 4.795540321082964 0.9999946362671487 1.2320514275332537 0.9999687057656278 0.0006119241864336914 423136.7834374314 0.036464823993987094 25.061261454508784 0.00020947792270935563 9.263089203537111e-11 10.033244153673182 0.232056791266105 QLVESK(ub)YTVENGYSTSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLVESKYTVENGYSTSAK 18 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 13360100.0 2306300.0 2632500.0 8421300.0 True False 2233087.7689047926 3683670.978306142 6215508.896415323 1.0 1.6495862946366775 2.7833697282143506 21.090608525041326 -6.962617767708418 0.39682064058833477 0.9354463404809902 3.5386965609578844 0.9998553059122253 0.008864664560491996 0.07877893108787247 0.01777080769671864 0.014597417923117759 0.09510759149022399 1.0898889069499601e-07 6.962617767708418 2.603250220476894 QLVESK(ub)YTVENGYSTSAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLVESKYTVENGYSTSAK 18 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 53820400.0 7105400.0 8675000.0 38040000.0 True False 10779411.274320805 7126878.471915629 30521377.3264757 1.0 0.6611565595324855 2.8314512314030624 23.36177505057548 -6.867010591795992 1.1498566327284967 0.8114408437756517 2.951502965072158 0.9616040092516791 0.1868001824296857 0.1397499227282768 0.34722367933810094 0.12629816539849847 0.2975460392393316 1.358280319747919e-07 6.867010591795992 2.140062121296506 up QLVESK(ub)YTVENGYSTSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLVESKYTVENGYSTSAK 18 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 10978100.0 2171000.0 3729200.0 5077900.0 True False 2973677.369068993 3564431.613184713 3878604.6026332495 1.0 1.198661176313379 1.304312513178783 21.503816699130994 -13.572447157209412 0.081545153126767 4.746995552349043e-18 1.6172392311974928 0.9998891025085723 0.0013284935049756252 10.64167477969544 0.07692894695697895 1.986144259395149 0.2740513272525734 2.676411225782711e-14 13.572447157209412 1.6172392311974928 QLVESK(ub)YTVENGYSTSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLVESKYTVENGYSTSAK 18 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 14667600.0 2306300.0 4022200.0 8339100.0 True False 1917790.6364135589 4000531.610255812 10082767.254358023 1.0 2.0860106073607523 5.257491126984386 20.871013800475602 -6.952054404545057 0.5358155771597485 0.9519786346326597 6.536936111619679 0.9993527980851034 0.04595214524773535 0.0826711434227121 0.03262836036054177 0.050837711324766784 0.262475213719989 1.1167233458621876e-07 6.952054404545057 5.584957476987019 QLVESK(ub)YTVENGYSTSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLVESKYTVENGYSTSAK 18 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 66175000.0 7105400.0 8936600.0 50133000.0 True False 9198080.368373342 8439270.354097243 41009308.408019334 1.0 0.9175034372514086 4.458463806103026 23.13290137266793 -6.901566453527809 0.9513080929247945 0.8590405292298314 4.842206340697177 0.987329758394262 0.18574151534894723 0.11026153270132785 0.17098660147415826 0.14599424834776026 0.38292777857319327 1.2543927823830421e-07 6.901566453527809 3.983165811467346 up QLWIWLHPTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLWIWLHPTLK 11 0 Q99575 Q99575 POP1 Ribonucleases P/MRP protein subunit POP1 0 4004930.0 614920.0 2438900.0 951110.0 False True 806166.0748937515 2075025.6267577412 852698.2608913458 1.0 2.5739431258394476 1.057720347514905 19.620717547364883 -6.637396818396472 2.053353123876102 2.0312546929105366 1.0639197021238396 0.14490914976722857 0.6738742153297491 0.5399435562053028 4.347500409626242 0.2675203754194415 0.7464424314384357 2.30464045768813e-07 6.637396818396472 -0.967334990786697 QLWIWLHPTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLWIWLHPTLK 11 0 Q99575 Q99575 POP1 Ribonucleases P/MRP protein subunit POP1 0 5045800.0 2321200.0 1373200.0 1351400.0 False True 2247514.776560639 1921525.9211433982 997427.7988690168 1.0 0.8549558566568803 0.4437914309935598 21.099899170269982 -6.952716922596224 0.5281737899647645 1.006570878763136 0.273569347345502 0.9993976167465908 0.005781841507998648 0.08241274287516097 0.03158648672952505 0.006468021016140481 0.03399325540665536 1.1150210784588766e-07 6.952716922596224 -0.733001531417634 down QLWIWLHPTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLWIWLHPTLK 11 0 Q99575 Q99575 POP1 Ribonucleases P/MRP protein subunit POP1 0 29779800.0 8225800.0 10847000.0 10707000.0 False True 12479139.98653251 8911268.102002172 8590756.756955191 1.0 0.7140931275407773 0.6884093588361327 23.573015176943986 -13.999999999999998 0.3410759211171415 4.328598839613623 0.6844301177610685 0.9997373430909441 0.002288723170053251 19.80297394011619 0.18740486881273571 47.55090384656095 0.007905024892187956 1.0000000000000041e-14 13.999999999999998 -3.6441687218525542 QLWIWLHPTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLWIWLHPTLK 11 0 Q99575 Q99575 POP1 Ribonucleases P/MRP protein subunit POP1 0 6239320.0 614920.0 1774800.0 3849600.0 False True 842272.5415881661 1696383.4675212447 2940403.765000682 1.0 2.014055289422816 3.4910360005994456 19.683927608887775 -6.965741564096858 0.3450881261964928 0.8489544949433214 4.705602178358998 0.9999276261087294 0.008701231190133413 0.07771021256583369 0.013977635009962845 0.020541429286488326 0.127375193692145 1.0820776724217769e-07 6.965741564096858 3.856647683415676 QLWIWLHPTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLWIWLHPTLK 11 0 Q99575 Q99575 POP1 Ribonucleases P/MRP protein subunit POP1 0 19107800.0 8225800.0 10882000.0 0.0 False True 10648460.25475912 10276407.133953214 0.0 1.0 0.9650603832005079 0.0 23.344141499036436 -7.052048579604135 1.048406156005108 1.0119081675140669 1.4923796295934346e-19 0.9879504915665014 0.05086630152475025 0.085132584496728 0.18009192084182346 0.040624095059467125 0.07271707964249972 8.8705678149433e-08 7.052048579604135 -1.0119081675140669 down QLYHLGVVEAYSGLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLYHLGVVEAYSGLTK 16 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 35615000.0 12035000.0 13120000.0 10460000.0 False True 15778001.547105795 11162547.141359441 9377699.53940498 1.0 0.7074753483851077 0.5943528089668086 23.91141114835482 -13.999999999999998 0.13150078807583282 2.3905435326437345 0.43891103941459664 0.9996388749966622 0.0032480012895706 11.934714748253285 0.11291524331121634 4.283860686804604 0.13832100837577666 1.0000000000000041e-14 13.999999999999998 -1.951632493229138 QLYHLGVVEAYSGLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLYHLGVVEAYSGLTK 16 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 37135400.0 4498800.0 24776000.0 7860600.0 False True 6825008.506335255 20354529.22422844 6306948.964576632 1.0 2.9823448872385327 0.9240939346408523 22.70239941345777 -6.654761191043095 1.9919630727489996 2.2815116418319192 0.9328114726792004 0.21340472297907898 0.8451126544351562 0.49697388537287424 3.785175606103624 0.343477376969674 0.9361207797719833 2.214311976218331e-07 6.654761191043095 -1.348700169152719 QLYHLGVVEAYSGLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLYHLGVVEAYSGLTK 16 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 35115800.0 12035000.0 9364800.0 13716000.0 False True 16484664.733645963 8951032.170747675 10476563.28988709 1.0 0.5429914599644968 0.6355339013054927 23.97462120987771 -9.938594852590493 5.678530976327139 1.0000003857821742 0.5892626806345506 0.9633235716199904 0.03778029347445872 1.8453019501449418e-07 3.446119567606077e-08 0.03658064619958732 0.012193537286544497 1.1518744558731346e-10 9.938594852590493 -0.41073770514762364 QLYHLGVVEAYSGLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLYHLGVVEAYSGLTK 16 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 21301200.0 4498800.0 9533600.0 7268800.0 False True 5823785.284605802 9003046.779292073 5945952.9841862805 1.0 1.5459098059624752 1.0209773701484854 22.47352573555022 -10.522058084877425 3.0739871123234432 0.9903879182538592 1.2834435880222475 0.279925560244467 0.21430277172017825 27447010.084334683 33128937.56074434 2212368.985082955 0.08221931709543129 3.00567428071709e-11 10.522058084877425 0.29305566976838826 QLYLNPK(ub)GDSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLYLNPKGDSAR 12 1 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 12749900.0 1182800.0 3045100.0 8522000.0 True False 1145252.6614319873 4261024.309986714 6289832.545480066 1.0 3.720597605648753 5.492091620739358 20.127234484836954 -8.271227967998412 0.27340152858395644 5.766004366916269e-17 6.736262155557324 0.9992038838981689 0.05212770098319589 0.10018100126226599 0.0654125166999431 0.5544063285919966 0.5921940015496238 5.3551548323071935e-09 8.271227967998412 6.736262155557324 QLYLNPK(ub)GDSAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLYLNPKGDSAR 12 1 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 82579700.0 6155700.0 17234000.0 59190000.0 True False 9338646.941950714 14158458.050143424 47491070.55610137 1.0 1.5161145011855346 5.085433773362155 23.154782105175038 -6.932908858560237 0.7225150153895987 0.9511452512216755 5.875606984907248 0.9970797205496635 0.09816317141746422 0.09115528418931479 0.07048508697841212 0.09103217806609541 0.3179539313507507 1.1670545104971892e-07 6.932908858560237 4.924461733685572 up QLYLNPK(ub)GDSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLYLNPKGDSAR 12 1 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 5978400.0 1182800.0 4795600.0 0.0 True False 983550.6069244941 4769765.150947931 0.0 1.0 4.849537092822007 0.0 19.90763976027123 -6.695187018009092 1.8478224739340072 3.40162198752411 0.015579632766370742 0.3947890260368282 1.6264190831621146 0.40566391929834217 2.6893040605385092 0.7030720716109881 1.8190778304841777 2.0174973920225315e-07 6.695187018009092 -3.3860423547577394 QLYLNPK(ub)GDSAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLYLNPKGDSAR 12 1 Q15021;E7EN77 Q15021 NCAPD2 Condensin complex subunit 1 1 62469700.0 6155700.0 11247000.0 45067000.0 True False 7968674.996987615 10621094.563092427 36865268.42646966 1.0 1.3328557843189115 4.626273306466355 22.925908427267487 -6.92636972978692 0.7760121892702595 0.942604812433848 5.243862298840361 0.9957753589545815 0.10637693866565778 0.09456721670631617 0.0872395905030894 0.0948977977589796 0.3041627039368703 1.1847596921479023e-07 6.92636972978692 4.301257486406513 up QLYLPMLFK ddPTM_RPMI8226_Bortezomib_1h_R1 2 QLYLPMLFK 9 0 O14980 O14980 XPO1 Exportin-1 0 10309730.0 2869880.0 3944810.0 3495040.0 False True 3762440.471957454 3356259.7247489486 3133406.78759101 1.0 0.8920432761033997 0.8328123224660131 21.843237325551023 -13.999999994419529 0.07243256480048134 1.612931876399568 0.6282112994249397 0.9999159213347044 0.0006346236629802595 12.335172848720239 0.07345003051808424 1.2593080680039763 0.18775015723840793 1.00000001284951e-14 13.999999994419529 -0.9847205769746282 QLYLPMLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLYLPMLFK 9 0 O14980 O14980 XPO1 Exportin-1 0 6370000.0 2894300.0 1259400.0 2216300.0 False True 2802422.03075972 1762284.987684239 1635784.5424251934 1.0 0.6288435390320186 0.5837038549050165 21.418242804120773 -13.999999999999998 0.29718654020417534 4.331408219300362 0.5722701669171176 0.999643546346649 0.0035214318007235 16.407561559961646 0.17305324366723912 33.557076742255376 0.016513200043704285 1.0000000000000041e-14 13.999999999999998 -3.759138052383244 QLYLPMLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QLYLPMLFK 9 0 O14980 O14980 XPO1 Exportin-1 0 20070350.0 2869880.0 6355630.0 10844840.0 False True 3930952.191590848 6074817.251342153 8283512.14849075 1.0 1.5453805987102804 2.107253343403912 21.906447387073914 -6.970752027995955 0.23954543266490938 0.7971066649011458 2.8717694435159524 0.9999876681473178 0.001587445135353274 0.07605945397428177 0.008152060291126861 0.013474202631626641 0.05482128625167321 1.0696654588823387e-07 6.970752027995955 2.0746627786148064 QLYLPMLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLYLPMLFK 9 0 O14980 O14980 XPO1 Exportin-1 0 5782500.0 2894300.0 1291200.0 1597000.0 False True 2406738.6892302674 1284244.0493168663 1930925.3163062872 1.0 0.5336034423112208 0.8022995287967234 21.19864807955505 -10.206023744501204 5.589803217955597 1.000012106831934 0.6679514855539548 0.6706402732773624 0.10969471796209995 1.6551245647761045e-05 2.351048813565781e-06 0.10621532423280096 0.03540381798616855 6.222662626186595e-11 10.206023744501204 -0.3320606212779793 QLYPSCSFIQNLVSASLGSTSK(ub)NTSPMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QLYPSCSFIQNLVSASLGSTSKNTSPMR 28 1 E9PMH5;Q13490-2;Q13490;A0A087X2B2;H0YDY3;E9PNM6 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 62354700.0 5252700.0 15944000.0 41158000.0 True False 7968729.923807941 13098668.628959408 33023103.259807795 1.0 1.6437586358429463 4.144086143658305 22.92591837150266 -6.945551447286814 0.6057183577254125 0.9721540992040802 4.944946328511919 0.9988043115894806 0.046892602736119275 0.08532278392273782 0.04374513346513977 0.047860476112894415 0.2105218612651961 1.1335705453942838e-07 6.945551447286814 3.9727922293078386 QLYVLGHEAMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLYVLGHEAMK 11 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 16714400.0 2864100.0 5248900.0 8601400.0 False True 3754862.835983856 4465784.580051953 7711409.638454883 1.0 1.189333612204191 2.053712738732925 21.84032877680801 -6.941853254573955 0.6421000553840789 0.9905225692159179 2.300084105232923 0.9983966035707131 0.018365803469370823 0.08693142400330243 0.05083699162437965 0.018139440751442453 0.07380930373999507 1.1432645715779217e-07 6.941853254573955 1.309561536017005 up QLYVLGHEAMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLYVLGHEAMK 11 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 11965800.0 3136000.0 1594200.0 7235600.0 False True 3036449.3965596147 2230772.373643174 5340379.296652856 1.0 0.7346647621299744 1.758757877771209 21.5339538957192 -6.837911271163773 1.2920371229610146 0.858786916860642 1.7910771342360061 0.9208084989104484 0.12212030946565923 0.17125084919244724 0.5562205633649646 0.07413846799524375 0.170719241045719 1.45240832257011e-07 6.837911271163773 0.9322902173753641 QLYVLGHEAMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLYVLGHEAMK 11 0 P22314-2;P22314;Q5JRR9;Q5JRS0;Q5JRS1;Q5JRS3;Q5JRS2 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 16989600.0 2864100.0 6813700.0 7311800.0 False True 3923035.1693922225 6512648.204107226 5584903.431247916 1.0 1.6601044657767368 1.4236179871191823 21.903538838330903 -10.283048321567573 5.218532334106847 0.999901722848613 1.5418612264480367 0.8750010620704066 0.09654520063003502 0.00011041060100613091 1.516904706047094e-05 0.09349631118580368 0.031159829516326152 5.211367238511376e-11 10.283048321567573 0.5419595035994237 QLYYFAQQNSGHFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QLYYFAQQNSGHFLR 15 0 Q15306;Q15306-2 Q15306 IRF4 Interferon regulatory factor 4 0 16223300.0 6558400.0 6020600.0 3644300.0 False True 8598125.91163595 5122349.94811499 3267222.7945940355 1.0 0.5957519116093486 0.37999243418527545 23.035590806740377 -10.256092875825496 0.13273144739803508 1.7960835884164512 2.2509921973075567e-05 0.9998015686677968 0.0036200510815742834 1.9466318267053868 0.06592771198929591 0.7416034926494596 0.2253793139027707 5.5450711643986224e-11 10.256092875825496 -1.7960610784944782 QLYYFAQQNSGHFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QLYYFAQQNSGHFLR 15 0 Q15306;Q15306-2 Q15306 IRF4 Interferon regulatory factor 4 0 13875700.0 5147200.0 1797700.0 6930800.0 False True 4983804.953434831 2515530.984881656 5115415.56045685 1.0 0.5047410579637462 1.0264076560482793 22.248816177369367 -11.013002500530222 13.089473658348004 1.3468973674557283 0.7655743570060148 0.21213591878248428 0.21296949686010974 0.04941372495151205 4.908542146972622e-05 0.00472616545858607 0.06873560954911483 9.705043793722411e-12 11.013002500530222 -0.5813230104497135 QLYYFAQQNSGHFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QLYYFAQQNSGHFLR 15 0 Q15306;Q15306-2 Q15306 IRF4 Interferon regulatory factor 4 0 19748000.0 6558400.0 4385700.0 8803900.0 False True 8983217.714095863 4191925.272429532 6724600.142012016 1.0 0.466639616877129 0.7485736576839527 23.098800868263268 -10.150367984985863 5.172476028138338 1.000015813220075 0.6076066372801988 0.7208869444450432 0.11509909018416238 2.0989887021352913e-05 3.447924572969924e-06 0.11144870131411802 0.0371480716204002 7.073461841295092e-11 10.150367984985863 -0.3924091759398761 QLYYFAQQNSGHFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QLYYFAQQNSGHFLR 15 0 Q15306;Q15306-2 Q15306 IRF4 Interferon regulatory factor 4 0 13108300.0 5147200.0 4399200.0 3561900.0 False True 4280124.859622718 4375500.636427167 4306676.821635163 1.0 1.0222834099313767 1.0062035484672254 22.029221452803643 -6.561716892845427 2.3380875522884765 1.0153360571867496 1.0062288131543529 0.0 0.009724803017455114 0.7559904020003986 7.746035324031587 0.003532858682950713 0.010941052857990347 2.743361927312523e-07 6.561716892845427 -0.00910724403239671 QLYYFAQQNSGHFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QLYYFAQQNSGHFLR 15 0 Q15306;Q15306-2 Q15306 IRF4 Interferon regulatory factor 4 0 33009700.0 2538700.0 16728000.0 13743000.0 False True 3286397.1952584544 15797072.094906216 11241915.015088048 1.0 4.806805494386955 3.4207414220373753 21.64807542484035 -9.592221916922663 11.184948302570346 1.0000000223962242 4.113773457214526 0.8706160201435227 0.5658582880100963 0.0 0.0 0.547889947772528 0.18262997714804519 2.5572788280125477e-10 9.592221916922663 3.1137734348183015 QMADTGK(ub)LNTLLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QMADTGKLNTLLQR 14 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4;A0A1W2PPE9 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 18479200.0 5068500.0 6884100.0 6526600.0 True False 6644852.583423821 5857019.114011633 5851290.039567924 1.0 0.8814370282077425 0.8805748458836379 22.663805762877917 QMADTGK(ub)LNTLLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QMADTGKLNTLLQR 14 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4;A0A1W2PPE9 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 36995200.0 7303200.0 12464000.0 17228000.0 True False 7071363.913569558 17440940.198901337 12715469.971078476 1.0 2.466418135465088 1.7981637102112915 22.75355707595238 -10.140655394989386 5.186801073500792 0.9999604911833557 2.132290922839231 0.7928745833462114 0.27281372670841914 0.0001246497297201441 2.0652044531272277e-05 0.2641599134145929 0.08805025167934961 7.233435362852458e-11 10.140655394989386 1.1323304316558753 QMADTGK(ub)LNTLLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QMADTGKLNTLLQR 14 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4;A0A1W2PPE9 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 45991400.0 6142100.0 5666300.0 34183000.0 True False 9318014.747657547 4655104.493996031 27426715.06705884 1.0 0.49958114684957716 2.9434075615681583 23.151591183131305 -6.853345235528819 1.218766999000937 0.7319758015846469 3.047630464282999 0.9450398950953904 0.24711125271506554 0.1538178679574504 0.43798244167869665 0.15850377674491725 0.36767568971369213 1.4016990031127442e-07 6.853345235528819 2.315654662698352 up QMADTGK(ub)LNTLLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QMADTGKLNTLLQR 14 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4;A0A1W2PPE9 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 31310700.0 8637300.0 13088100.0 9585300.0 True False 11830743.224255927 12509824.465441061 7321449.555450175 1.0 1.0573997109321798 0.6188495022391668 23.49603737290763 -6.873961249012487 1.1128671396077292 1.0333907773720818 0.5911487448037617 0.9684821347268547 0.034551630324806515 0.13311652116082726 0.3057228034812372 0.024031609786158606 0.05732375229824784 1.3367147828718045e-07 6.873961249012487 -0.4422420325683202 QMADTGK(ub)LNTLLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QMADTGKLNTLLQR 14 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4;A0A1W2PPE9 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 21807300.0 7303200.0 10262000.0 4242100.0 True False 6072934.386617308 10206716.569152474 5129103.496745715 1.0 1.6806894195406794 0.84458404623118 22.533962351386656 -6.690236137839262 1.8658534095595252 1.4266585199851796 0.8474863371888434 0.3714433219900598 0.28787014381397247 0.41614045713842024 2.809138360766987 0.12342428624630986 0.32127701206631615 2.0406280974199368e-07 6.690236137839262 -0.5791721827963362 QMCICADFEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QMCICADFEK 10 0 P14868;P14868-2 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 5175000.0 1143700.0 2458800.0 1572500.0 False True 1499401.775606556 2091956.6243273348 1409792.7844851182 1.0 1.3951941756778774 0.9402368380648422 20.51595558503747 -6.677038171145343 1.9122833892756852 1.2507064759235718 0.9420022493816286 0.31063458626569473 0.16760246860805753 0.44516282978679417 3.144685886200007 0.0703921222664164 0.18637061026029395 2.10359354194482e-07 6.677038171145343 -0.3087042265419432 QMCICADFEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QMCICADFEK 10 0 P14868;P14868-2 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 18078900.0 2764100.0 10515000.0 4799800.0 False True 4193341.782777908 8638516.095930027 3851117.4261729266 1.0 2.0600553313847416 0.918388632662737 21.999668992693156 -6.662764947851951 1.9625885608151135 1.6807531023164068 0.9230684094822564 0.24768524488259402 0.4510443480097697 0.47788465935495567 3.541154366822443 0.18546918834431952 0.5003282570922497 2.1738774229269875e-07 6.662764947851951 -0.7576846928341504 QMCICADFEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QMCICADFEK 10 0 P14868;P14868-2 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 4605000.0 1143700.0 1696200.0 1765100.0 False True 1566556.7973303609 1621256.2754166883 1348219.7333755959 1.0 1.0349170091882678 0.8606261424246839 20.579165646560362 -6.8546023139605285 1.2126464818546978 1.0187346019282648 0.8530136580066264 0.9467419515456714 0.01737593891877435 0.15246666804371126 0.4291333339123698 0.01119755954598427 0.02600040607026125 1.39764760948552e-07 6.8546023139605285 -0.1657209439216384 QMEQISQFLQAAER ddPTM_RPMI8226_Bortezomib_1h_R1 2 QMEQISQFLQAAER 14 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 57778500.0 6933600.0 29417100.0 21427800.0 False True 9090016.745077923 25028183.34695771 19210656.805971507 1.0 2.753370433614439 2.1133796938684104 23.11585152139137 -10.261635976150501 5.430675501032603 0.9998598657060697 2.4333750637415115 0.8699310104248179 0.2612751254143247 0.0004433422508265251 6.027792558902768e-05 0.2530024927510439 0.08432618412561689 5.4747466163832383e-11 10.261635976150501 1.4335151980354417 QMEQISQFLQAAER ddPTM_RPMI8226_Bortezomib_2h_R1 2 QMEQISQFLQAAER 14 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 68664300.0 21358600.0 11938200.0 35367500.0 False True 20680582.934106562 16705185.516890546 26103690.74774305 1.0 0.8077715009348329 1.2622318641073054 24.301773516416212 -6.791786110477493 1.4891214573639107 0.8928107672342811 1.267309912164612 0.8070644749564295 0.08181579580924797 0.23270807506769914 1.0193675947151328 0.04324088553784787 0.10111034711403208 1.6151538223381737e-07 6.791786110477493 0.374499144930331 QMEQISQFLQAAER ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QMEQISQFLQAAER 14 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 75805100.0 6933600.0 33601400.0 35270100.0 False True 9497139.293494616 32116779.043029293 26940028.790510815 1.0 3.381731914264831 2.8366466951752822 23.17906158291426 -9.998303227039823 5.276851582506166 0.9999914280472949 3.1091893047129746 0.9522984980755946 0.22253010887912922 2.8594803441526313e-05 5.427364326726529e-06 0.2154649583805209 0.0718212838057168 1.0039146062579052e-10 9.998303227039823 2.1091978766656796 QMEQISQFLQAAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QMEQISQFLQAAER 14 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 22164200.0 15993000.0 2828700.0 3342500.0 False True 13298888.110029945 2813461.231647013 4041401.2960261516 1.0 0.2115561247203153 0.3038901645452713 23.664802294509258 -10.620855388643566 6.578148323911201 1.002379558736681 0.25772314477878233 0.9885279230538111 0.037695213910160535 0.0013179918737852027 7.596494700471361e-05 0.03656759773887396 0.01216607797548149 2.3941128152698593e-11 10.620855388643566 -0.7446564139578987 QMFFVISLDPPIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QMFFVISLDPPIK 13 0 Q08945;E9PMD4 Q08945 SSRP1 FACT complex subunit SSRP1 0 1379390.0 422160.0 489200.0 468030.0 False True 553455.8482032558 416213.26688666444 419602.745260776 1.0 0.7520261430751216 0.7581503504262865 19.078108705411353 -10.116915561800568 4.727834582279268 1.0000163053262467 0.755088246748248 0.9995312508662313 0.002500197191608601 4.313197785042614e-07 8.055941148605298e-08 0.0024209671967955907 0.0008069351723513429 7.639843076581591e-11 10.116915561800568 -0.2449280585779987 QMFFVISLDPPIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QMFFVISLDPPIK 13 0 Q08945;E9PMD4 Q08945 SSRP1 FACT complex subunit SSRP1 0 256077000.0 72646000.0 95400000.0 88031000.0 False True 110209293.1339982 78375124.63639799 70631634.264642 1.0 0.7111480566444195 0.6408863740625247 26.715670639932238 -13.999999999999998 0.19856240662210284 2.5969900166299964 0.5946034131353856 0.9994869252524712 0.0035199221875557075 12.502868569116776 0.1412993497783393 7.750044839908063 0.04522337859779963 1.0000000000000041e-14 13.999999999999998 -2.0023866034946107 QMFFVISLDPPIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QMFFVISLDPPIK 13 0 Q08945;E9PMD4 Q08945 SSRP1 FACT complex subunit SSRP1 0 157254000.0 72646000.0 41442000.0 43166000.0 False True 94041679.06674518 39135716.26955417 35310230.920562506 1.0 0.4161528872934943 0.37547427131220623 26.486796962024687 -13.999999999999998 0.37829447516662906 9.569311277283406 0.37179321017767314 0.9998047558258703 0.003986486447534286 23.821259044154896 0.20041751022841742 166.12460062448176 0.011082510973952471 1.0000000000000041e-14 13.999999999999998 -9.197518067105733 QMFGNADMNTFPTFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QMFGNADMNTFPTFK 15 0 A8MUH2;P18859;P18859-2 A8MUH2 ATP5J ATP synthase-coupling factor 6, mitochondrial 0 13076200.0 2531800.0 4998600.0 5545800.0 False True 3319214.317986077 4252828.364390189 4971973.815069995 1.0 1.2812756143359187 1.497936963011995 21.662410354966138 -6.974033945602501 0.12957100638853514 0.6622735605570301 2.1225447312584507 0.9999992308608655 0.00017868579546108615 0.07501403157533014 0.003888474097036757 0.013696198184393268 0.02966471416577906 1.0616125755159883e-07 6.974033945602501 1.4602711707014207 QMFGNADMNTFPTFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QMFGNADMNTFPTFK 15 0 A8MUH2;P18859;P18859-2 A8MUH2 ATP5J ATP synthase-coupling factor 6, mitochondrial 0 8419610.0 4107300.0 750410.0 3561900.0 False True 3976916.009722354 1050052.626336454 2628931.5352904764 1.0 0.2640369129670814 0.661047789006239 21.923218662863682 -10.753500703074835 6.795364661660808 1.0113577325199599 0.4625423509898669 0.7096025758646249 0.1620790114385467 0.027606039015566478 0.0010013972009562564 0.1553400641822998 0.05231077600593771 1.76400290874808e-11 10.753500703074835 -0.5488153815300929 QMFGNADMNTFPTFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QMFGNADMNTFPTFK 15 0 A8MUH2;P18859;P18859-2 A8MUH2 ATP5J ATP synthase-coupling factor 6, mitochondrial 0 11033900.0 2531800.0 4201200.0 4300900.0 False True 3467874.8793223794 4015577.0924894433 3285115.999815932 1.0 1.1579359787265695 0.9472994597941901 21.72562041648903 -6.706068798006519 1.8093809223278243 1.0974854836836525 0.9478533783481875 0.4463035748112214 0.06659608416827624 0.3830520689536594 2.4420730920503497 0.029318559848071322 0.0748355997721185 1.967574575106559e-07 6.706068798006519 -0.149632105335465 QMFGNADMNTFPTFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QMFGNADMNTFPTFK 15 0 A8MUH2;P18859;P18859-2 A8MUH2 ATP5J ATP synthase-coupling factor 6, mitochondrial 0 7285500.0 4107300.0 1571200.0 1607000.0 False True 3415401.934241608 1562735.6337412181 1943016.2700715093 1.0 0.4575554104112272 0.5688982753659292 21.70362393829796 -10.32676457824331 7.87380534385736 1.0000024344561664 0.5132268428887342 0.9622413191243995 0.04545553427310584 1.9425694676357767e-06 1.6608764712010934e-07 0.04401235142611009 0.014670710602724943 4.7123270235030926e-11 10.32676457824331 -0.4867755915674322 QMGQPCDAYQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 2 QMGQPCDAYQKR 12 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 13153900.0 4359200.0 5266400.0 3528300.0 True False 5714953.414552854 4480673.648266412 3163225.361843459 1.0 0.7840262768995793 0.5534997632331451 22.446310307682126 -6.970296753053878 0.25099813232332213 1.0722658687044204 0.25849978069150314 0.9999846043686631 0.0007153318355500837 0.0762065372140361 0.008684982967953954 0.005107017916962408 0.02205792362187751 1.0707873870863908e-07 6.970296753053878 -0.8137660880129173 QMGQPCDAYQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 QMGQPCDAYQKR 12 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 3458100.0 1421300.0 1313900.0 722900.0 True False 1376181.6094802865 1838547.1218979857 533550.8034648609 1.0 1.3359771044988102 0.3877037738255751 20.392239438933796 -6.810943213006122 1.4106264557564443 1.1829033312100976 0.3707654858103111 0.8622497429674499 0.14570172258717073 0.20552557987352477 0.8058719704527333 0.08121299166860987 0.18777789811094098 1.5454565054068195e-07 6.810943213006122 -0.8121378453997865 down QMGQPCDAYQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 QMGQPCDAYQKR 12 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 30538100.0 2259500.0 5487600.0 22791000.0 True False 3427826.6915765274 4508294.905185502 18286348.860349823 1.0 1.3152050295495088 5.334677189277489 21.708862739006886 -6.922535853989904 0.8056972282651723 0.9191556420133178 6.022227637756431 0.9948568098629998 0.14151669472529085 0.09670256061997921 0.09805078768616868 0.12359800044969975 0.3797063456619889 1.1952648442847502e-07 6.922535853989904 5.103071995743113 up QMGQPCDAYQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QMGQPCDAYQKR 12 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 10764730.0 4359200.0 2750430.0 3655100.0 True False 5970914.04295052 2628906.9081442775 2791840.6591474363 1.0 0.44028550557482254 0.4675734132270059 22.509520369205017 -10.65003648915893 6.583034743617027 1.0027128563432885 0.45392945940091506 0.9981306451573307 0.011140241649339622 0.00044500651337055534 2.365716621962925e-05 0.010821743110379286 0.0035954975317182185 2.2385330504779e-11 10.65003648915893 -0.5487833969423734 QMGQPCDAYQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 2 QMGQPCDAYQKR 12 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 11848300.0 3347200.0 3328000.0 5173100.0 True False 2783345.106102187 3310071.403443722 6254771.292288073 1.0 1.1892421806360784 2.2472137136624397 21.408388368397848 -6.937349512481266 0.6837838061780859 0.9874051890603318 2.5115572292833885 0.997795630672447 0.025766670911046452 0.08899698473654165 0.06027527385465095 0.024604136192034345 0.09217116953768942 1.1551821978964059e-07 6.937349512481266 1.5241520402230568 up QMGYQCFVSFFDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QMGYQCFVSFFDLR 14 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 19054600.0 5426900.0 8736900.0 4890800.0 False True 7025229.030191881 8250683.834647664 4000724.583845788 1.0 1.174436278047196 0.5694795951352088 22.74411382886926 -6.829595310316794 1.3297894517887967 1.0932320202436139 0.5533429352902411 0.9050508050908048 0.07834152018631334 0.18131033709122008 0.6272007160177809 0.04625884102428989 0.10645239039807974 1.4804873116975624e-07 6.829595310316794 -0.5398890849533727 QMK(ub)EDGACLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QMKEDGACLFR 11 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 61528000.0 20529000.0 26811000.0 14188000.0 True False 26913717.803118803 22810903.308459476 12719961.860906102 1.0 0.8475567543409448 0.47262002053956637 24.68183835974741 -6.955810530093141 0.4909289950919097 1.0081365445506973 0.29611613332932846 0.9995818893192122 0.004531152682525214 0.08123304634503561 0.026930113303232913 0.005409133621665836 0.030923711666062566 1.1071066767094662e-07 6.955810530093141 -0.7120204112213688 down QMK(ub)EDGACLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QMKEDGACLFR 11 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 48646500.0 29967000.0 13495000.0 5184500.0 True False 29015713.98810649 18883623.8754953 3826523.9183338913 1.0 0.650806796732132 0.13187764119478085 24.790331093858516 -7.449909210760924 0.5000932527999545 1.0133299462522833 7.491057768446732e-16 0.9974824151493538 0.017895627548004583 0.1133841743157594 0.06447059304621076 0.02006729681245024 0.06598878615385115 3.548875707078685e-08 7.449909210760924 -1.0133299462522827 down QMK(ub)EDGACLFR ddPTM_RPMI8226_Bortezomib_8h_R1 2 QMKEDGACLFR 11 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 145056900.0 49679000.0 64644300.0 30733600.0 True False 75366675.02138987 53108019.59677883 24659090.488984566 1.0 0.7046618360396847 0.3271882497401677 26.167423410396204 -7.0600933101881465 0.321365022985659 1.0540859073650235 7.066303217859262e-12 0.9999485922232128 0.0019742699791297546 0.07335984824706351 0.012844586570682296 0.006162549142867765 0.03210822109140214 8.70776479481819e-08 7.0600933101881465 -1.0540859073579572 down QMK(ub)EDGACLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QMKEDGACLFR 11 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 74355000.0 20529000.0 33067000.0 20759000.0 True False 28119126.07536501 31605990.60205374 15856151.74502523 1.0 1.124003303564386 0.5638920534915453 24.7450484212703 -6.848634332262573 1.2416071851766959 1.0661063572284548 0.5420778439547163 0.9382969980086084 0.05966745685388057 0.1589709887314739 0.4722726800287077 0.03761620891866335 0.08697655728158105 1.4169863535264078e-07 6.848634332262573 -0.5240285132737386 QMK(ub)EDGACLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QMKEDGACLFR 11 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 49742600.0 29967000.0 12062000.0 7713600.0 True False 24918888.263194375 11997019.61188045 9326478.09634326 1.0 0.48144281097805847 0.3742734426125514 24.570736369292792 -13.999999999999995 0.2216176176561005 4.151572716810545 0.3178293523251341 0.9994995649867546 0.006112394263599155 13.044089960627735 0.1491213419155232 18.006421222143903 0.05868358560684158 1.0000000000000123e-14 13.999999999999995 -3.833743364485411 QMK(ub)EDGACLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QMKEDGACLFR 11 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 126688700.0 45634000.0 71215000.0 9839700.0 True False 59074112.580621645 67251822.64698382 8048975.563847907 1.0 1.1384313654344211 0.13625216211014654 25.816022716211716 -6.871976937522642 1.1235371358225632 1.0793169763933805 0.07529924631780306 0.966619095293487 0.08101468013718009 0.13497587818534787 0.3172365397530247 0.05588906960648551 0.13279792059663825 1.3428362683039842e-07 6.871976937522642 -1.0040177300755775 down QMK(ub)NIVHNYSEAEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QMKNIVHNYSEAEIK 15 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 8684900.0 3115400.0 3248700.0 2320800.0 True False 4084319.5695765135 2764006.62333342 2080665.8786855729 1.0 0.6767361310123949 0.5094277867442456 21.961664320800942 -13.999999999908136 0.0837264028993601 2.7064001965614732 0.04250954795857435 0.999870845596175 0.002314063657727221 12.222088334182894 0.08247710293510936 3.8006099337201125 0.42217907861798815 1.0000000002115253e-14 13.999999999908136 -2.663890648602899 QMK(ub)NIVHNYSEAEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QMKNIVHNYSEAEIK 15 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 17131300.0 3798200.0 5396600.0 7936500.0 True False 3677628.2200295627 7551490.522897216 5857692.560103568 1.0 2.053358869112798 1.5927908449801054 21.810344211056098 -10.184086234093957 4.607531351191247 0.9998617551115841 1.8230748570533493 0.8098221934789335 0.18802610854573124 131972064.68406741 54.146477274341436 200564.73757192786 0.06436633814861302 6.545062015360151e-11 10.184086234093957 0.8232131019417651 QMK(ub)NIVHNYSEAEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QMKNIVHNYSEAEIK 15 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 9766800.0 3115400.0 2477700.0 4173700.0 True False 4267247.570519366 2368227.0213417825 3187958.020049705 1.0 0.5549776482861869 0.7470759470516727 22.024874382323834 -10.243918768677407 5.552614695443961 1.0000221087568177 0.6510267976689158 0.8148228675862126 0.07842380207207543 2.146538982015041e-05 2.9228442689158563e-06 0.07593832444018929 0.02531117328094406 5.702709269392275e-11 10.243918768677407 -0.34899531108790194 QMK(ub)NIVHNYSEAEIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QMKNIVHNYSEAEIK 15 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 19890400.0 3798200.0 11349200.0 4743000.0 True False 3158371.5887898267 11288059.606960181 5734739.370845783 1.0 3.5740125218405208 1.8157266203889348 21.590749486490374 -9.348601768752788 8.803813635227733 0.9999999999999938 2.6948695711150012 0.5533498510820112 0.7178172134152496 0.0 0.0 0.6950235282941525 0.23167450943138412 4.4812402824500477e-10 9.348601768752788 1.6948695711150075 QMLISLAPPVLTLHLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 QMLISLAPPVLTLHLK 16 0 Q9Y5T5-2;Q9Y5T5;Q9Y5T5-3;Q9Y5T5-4 Q9Y5T5-2 USP16 Ubiquitin carboxyl-terminal hydrolase 16 0 102515300.0 42430700.0 36872100.0 23212500.0 False True 64370473.99967969 30291985.671967763 18624539.20059984 1.0 0.47058820278562025 0.2893335724185054 25.939895756555657 -13.99999999999995 0.14959012013751907 3.558324512142619 0.08897469924736569 0.9995676137456807 0.0062695749407989795 11.956210956603229 0.12178710734098808 8.892067644080466 0.18052103988003954 1.0000000000001145e-14 13.99999999999995 -3.469349812895253 QMLISLAPPVLTLHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 QMLISLAPPVLTLHLK 16 0 Q9Y5T5-2;Q9Y5T5;Q9Y5T5-3;Q9Y5T5-4 Q9Y5T5-2 USP16 Ubiquitin carboxyl-terminal hydrolase 16 0 79195200.0 42430700.0 24660500.0 12104000.0 False True 54927377.58413869 23288121.4966783 9901196.197527891 1.0 0.4239802175336909 0.18025976540316477 25.711022078648107 -9.95671097804936 0.21781028633460617 1.5919071154192026 1.3985290518759141e-24 0.9993017398288189 0.00908216024602573 1.4419840861177247 0.09835855741585707 0.6429864619332201 0.12840561184421137 1.104813626157909e-10 9.95671097804936 -1.5919071154192026 QMLLFTHIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QMLLFTHIR 9 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 3287930.0 799100.0 896630.0 1592200.0 False True 1047627.8384954085 762856.2990363651 1427454.417460862 1.0 0.7281749023889732 1.3625586921315076 19.998694871205934 -6.790262312444457 1.495205634841216 0.8481285121177724 1.3693617615902567 0.8021938502780112 0.11557715878949149 0.2349625883149968 1.0377143510776063 0.06084094225331217 0.14242123988272534 1.6208308251410425e-07 6.790262312444457 0.5212332494724843 QMLQGK(ub)PLADTMRPDTLQDYFGQSK ddPTM_RPMI8226_Bortezomib_1h_R1 3 QMLQGKPLADTMRPDTLQDYFGQSK 25 2 Q96S55-2;Q96S55 Q96S55-2 WRNIP1 ATPase WRNIP1 1 116276600.0 23467800.0 55880100.0 36928700.0 True False 30766513.062498495 47543006.898923814 33107672.36910367 1.0 1.5452842121674912 1.076094398538092 24.874857608614143 -10.311991716908127 3.738683013814011 0.9991694404983952 1.310689305429429 0.36894487899554795 0.19154593960766794 20988996.219832186 11810524.172119942 134750.90058578088 0.06557126992967931 4.875377885908245e-11 10.311991716908127 0.3115198649310339 QMLQGK(ub)PLADTMRPDTLQDYFGQSK ddPTM_RPMI8226_Bortezomib_2h_R1 3 QMLQGKPLADTMRPDTLQDYFGQSK 25 2 Q96S55-2;Q96S55 Q96S55-2 WRNIP1 ATPase WRNIP1 1 266058500.0 74029000.0 82433500.0 109596000.0 True False 71678989.91642591 115349626.43502343 80889519.79047562 1.0 1.6092529564034772 1.1284969261535176 26.095046971628946 -10.19747708822387 4.27891671030181 0.9998671688244858 1.3688749412969838 0.43976337586549874 0.19626782754688354 139028344.84007463 77172660.41198522 199377.8655605914 0.07182667217364855 6.346333810161696e-11 10.19747708822387 0.36900777247249805 QMLQGK(ub)PLADTMRPDTLQDYFGQSK ddPTM_RPMI8226_Bortezomib_8h_R1 3 QMLQGKPLADTMRPDTLQDYFGQSK 25 2 Q96S55-2;Q96S55 Q96S55-2 WRNIP1 ATPase WRNIP1 1 445918200.0 176109200.0 138459000.0 131350000.0 True False 267170531.70709896 113749909.6648953 105388614.92724979 1.0 0.42575769467569935 0.39446197248575343 27.99318564975319 -13.816277328282528 0.41589172377688693 9.999915022773218 0.3932621008903717 0.9998563914784208 0.0033358942150899964 24.90494150945691 0.21426415104973592 202.28364005616652 0.007677107936449963 1.526590908756858e-14 13.816277328282528 -9.606652921882846 QMLQGK(ub)PLADTMRPDTLQDYFGQSK ddPTM_RPMI8226_Carfilzomib_1h_R1 3 QMLQGKPLADTMRPDTLQDYFGQSK 25 2 Q96S55-2;Q96S55 Q96S55-2 WRNIP1 ATPase WRNIP1 1 159118600.0 23467800.0 80393200.0 55257600.0 True False 32144479.853448834 76841162.59923878 42206892.94599475 1.0 2.3904932650821653 1.3130370483025968 24.938067670137034 -6.58189173984726 2.260363079685857 1.9458377069830952 1.3158432910424318 0.0 0.6037916374852392 0.6935949102171158 6.66868799775272 0.22408613367249924 0.6742822696491718 2.618835745556065e-07 6.58189173984726 -0.6299944159406634 QMLQGK(ub)PLADTMRPDTLQDYFGQSK ddPTM_RPMI8226_Carfilzomib_2h_R1 3 QMLQGKPLADTMRPDTLQDYFGQSK 25 2 Q96S55-2;Q96S55 Q96S55-2 WRNIP1 ATPase WRNIP1 1 242278400.0 74029000.0 93293900.0 74955500.0 True False 61558393.54076205 92791307.2433107 90628348.4949254 1.0 1.5073705128751806 1.4722338138163746 25.875452247063222 -10.187305303806276 5.000851828442828 0.9999577487803912 1.4898021633464307 0.9961552431526475 0.014344497325605382 6.75806403789345e-06 1.0982678772683646e-06 0.01389019465050899 0.004629666603985803 6.496728175836258e-11 10.187305303806276 0.48984441456603944 QMLQGK(ub)PLADTMRPDTLQDYFGQSK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 QMLQGKPLADTMRPDTLQDYFGQSK 25 2 Q96S55-2;Q96S55 Q96S55-2 WRNIP1 ATPase WRNIP1 1 305111300.0 130867200.0 97370800.0 76873300.0 True False 169410170.17817295 91952029.3841877 62883148.18666725 1.0 0.5427775043698937 0.37118874339439867 27.335945245487967 -13.999999999999998 0.13601215499240293 3.177625818138933 0.14827908277583243 0.9996193005500054 0.005178208509401631 11.932006525308475 0.11523921929249237 6.913325244463003 0.19879194950521778 1.0000000000000041e-14 13.999999999999998 -3.0293467353631005 QMLQGKPLADTMRPDTLQDYFGQSK(ub)AVGQDTLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QMLQGKPLADTMRPDTLQDYFGQSKAVGQDTLLR 34 3 Q96S55-2;Q96S55 Q96S55-2 WRNIP1 ATPase WRNIP1 1 12408800.0 2146400.0 2888900.0 7373500.0 True False 2078263.706879958 4042452.83541448 5442159.149741528 1.0 1.9451106334736061 2.6186085681646705 20.98694729597715 -7.801285651091519 0.1497756055598016 6.079924169555768e-14 4.018388309474112 0.999965474344703 0.0039009052873286176 0.13175619492175378 0.020952845447896183 0.21320200953094182 0.29703253171059696 1.5802083375588654e-08 7.801285651091519 4.018388309474052 QMNDEK(ub)TAADYK ddPTM_RPMI8226_Bortezomib_1h_R1 2 QMNDEKTAADYK 12 1 Q15843;S4R3E9 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 29583300.0 2691600.0 24022300.0 2869400.0 True False 3528713.6654914813 20438266.478192013 2572502.0132283596 1.0 5.791987793757519 0.7290197667171898 21.750710937913027 -6.658615081608949 1.9777996001997553 4.088109081731554 0.7502083220717646 0.22968336795044098 2.041009606162802 0.4877718069032339 3.6664037801685305 0.8341601640345873 2.2622284853063257 2.1947492960034152e-07 6.658615081608949 -3.3379007596597896 QMNDEK(ub)TAADYK ddPTM_RPMI8226_Bortezomib_2h_R1 2 QMNDEKTAADYK 12 1 Q15843;S4R3E9 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 84514000.0 44180700.0 25263200.0 15070100.0 True False 42778207.86179254 35350927.50584761 11122788.716690825 1.0 0.8263770099967506 0.2600106286038497 25.350372708120243 -6.949554264245954 0.5637147049743196 1.0072682941705355 0.05187856866822448 0.9991658466775849 0.009125583913465147 0.0836652007503352 0.036706744429498804 0.009738792165374304 0.04711934257876743 1.123170622934274e-07 6.949554264245954 -0.955389725502311 down QMNDEK(ub)TAADYK ddPTM_RPMI8226_Bortezomib_8h_R1 2 QMNDEKTAADYK 12 1 Q15843;S4R3E9 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 100394200.0 37109500.0 21949500.0 41335200.0 True False 56297824.56785102 18032440.232773732 33165279.602138255 1.0 0.3203043878017125 0.5891041058285821 25.74657583969981 -10.359435383995663 5.854220002429176 1.0000969674394176 0.4547042468153532 0.8458486561596597 0.10973702536164136 0.00013890770381290828 1.5199360984205289e-05 0.10627112922811208 0.035417472640664346 4.370837052287895e-11 10.359435383995663 -0.5453927206240643 QMNDEK(ub)TAADYK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QMNDEKTAADYK 12 1 Q15843;S4R3E9 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 70487700.0 2691600.0 27808500.0 39987600.0 True False 3686757.2577550057 26579828.51958789 30543352.45047305 1.0 7.209541247576812 8.284611737381365 21.81392099943592 -9.437085957703601 0.5409991925263765 1.3545457408809437e-16 8.233554880706828 0.99834690166437 0.13054332844902092 0.7716391771585941 0.23500784998506993 1.8860815247311764 0.20205435993582843 3.6552243845118827e-10 9.437085957703601 8.233554880706828 QMNDEK(ub)TAADYK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 QMNDEKTAADYK 12 1 Q15843;S4R3E9 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 90512500.0 44180700.0 36583500.0 9748300.0 True False 36738209.5868693 36386417.424243845 11786624.458953409 1.0 0.9904243520143892 0.3208274053498268 25.13077798355452 -6.910014140820738 0.895637884573647 1.0207231540853794 0.2342669849692591 0.9909268097275165 0.030284076268236912 0.10440900840294119 0.13871674226783623 0.024795642901671144 0.06845395690520385 1.2302287133683015e-07 6.910014140820738 -0.7864561691161203 down QMNDEK(ub)TAADYK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 QMNDEKTAADYK 12 1 Q15843;S4R3E9 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 135313700.0 37109500.0 86791400.0 11412800.0 True False 48038979.28760537 81961382.29422781 9335787.505216978 1.0 1.7061432925860442 0.194337757455761 25.517702161792258 -6.779668052871705 1.5369513534875168 1.400000800881347 0.18243920115400566 0.7663000895010074 0.29858157731231 0.2510814345624857 1.1714515432602808 0.1530075536457526 0.36116594741951374 1.6608558751986436e-07 6.779668052871705 -1.2175615997273412 QMQVLHPAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QMQVLHPAAR 10 0 P50991 P50991 CCT4 T-complex protein 1 subunit delta 0 4322610.0 1311700.0 536710.0 2474200.0 False True 1270060.8014882791 751021.1019056748 1826132.7955910326 1.0 0.5913268884651942 1.437831002619039 20.276466133964078 -6.775378279614828 1.5534785780536151 0.7672213864722393 1.4436418817381649 0.7508861935715351 0.17251950713201814 0.2577924492956861 1.2283850461753014 0.08749256325229597 0.2072916482382061 1.6773423812150193e-07 6.775378279614828 0.6764204952659256 QMSGAQIK(ub)IANPVEGSSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QMSGAQIKIANPVEGSSGR 19 1 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 78524000.0 19513000.0 25516000.0 33495000.0 True False 25581731.964160822 21709112.260588992 30029258.70672753 1.0 0.8486177672021095 1.1738555758772529 24.60861060675474 -6.780153320029879 1.5354123448226011 0.914300254442438 1.1764379358035335 0.7678833201758396 0.06402121236456013 0.25033804087574824 1.1657322765048401 0.03284161833995261 0.07747799311458686 1.6590011228698522e-07 6.780153320029879 0.2621376813610955 QMSGAQIK(ub)IANPVEGSSGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QMSGAQIKIANPVEGSSGR 19 1 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 115456000.0 21597000.0 31286000.0 62573000.0 True False 20911415.056600098 43778662.9543347 46183254.150237575 1.0 2.093529435279283 2.208518841275695 24.317787355314778 -10.802486191690315 0.4240846431090406 6.083980872204871e-14 2.213863661827843 0.9995208007765454 0.011922176066621298 2.431460743168323 0.2047653067330622 2.489943144206716 0.02753568391709531 1.5758461256724792e-11 10.802486191690315 2.2138636618277823 QMSGAQIK(ub)IANPVEGSSGR ddPTM_RPMI8226_Bortezomib_8h_R1 2 QMSGAQIKIANPVEGSSGR 19 1 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 292357800.0 36890000.0 33691800.0 221776000.0 True False 55964827.02025149 27679235.054765124 177941876.3921259 1.0 0.4945826964630676 3.1795305349150045 25.738017065918065 -6.858022735487365 1.1957315939326965 0.7271034695734285 3.3046917668225158 0.9511844877283387 0.2573948607802984 0.14885506589738942 0.4055531623975271 0.16802501421745716 0.39137696483283674 1.3866832335576772e-07 6.858022735487365 2.577588297249087 up QMSGAQIK(ub)IANPVEGSSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QMSGAQIKIANPVEGSSGR 19 1 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 78126000.0 19513000.0 32825000.0 25788000.0 True False 26727483.418997407 31374682.96224076 19697405.52053136 1.0 1.1738734421939705 0.7369719480035597 24.671820668277633 -6.798716052176347 1.461115297610356 1.0960919064414196 0.7311285364865885 0.8283801504279907 0.07440206810982285 0.2226030380372452 0.9383359591072093 0.040061799513966635 0.09324419802221691 1.589585702347118e-07 6.798716052176347 -0.36496336995483114 QMSGAQIK(ub)IANPVEGSSGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QMSGAQIKIANPVEGSSGR 19 1 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 82929000.0 21597000.0 37796000.0 23536000.0 True False 17958862.409323867 37592385.4460814 28457268.781831432 1.0 2.0932498166790463 1.5845808121486031 24.098192630749054 -10.521963005919968 5.5914335698408 0.9982184349061629 1.838915314413429 0.7838604195252066 0.2076632515115114 0.004619360816800043 0.000394929997727926 0.20138940227250154 0.06702302622694675 3.0063323771778966e-11 10.521963005919968 0.840696879507266 QMSGAQIK(ub)IANPVEGSSGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 QMSGAQIKIANPVEGSSGR 19 1 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 1 172698100.0 36890000.0 37647100.0 98161000.0 True False 47754832.21061347 35552005.79053944 80296705.21691464 1.0 0.7444692849876257 1.6814362337780087 25.509143388010514 -6.834025746432792 1.309706869646363 0.86379072029777 1.7088087298848447 0.9137080777999766 0.1161708107193248 0.17589593861390285 0.5886275732770061 0.0696102383635958 0.1602137941997552 1.4654609609421743e-07 6.834025746432792 0.8450180095870746 QMSGAQIK(ub)IANPVEGSTDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QMSGAQIKIANPVEGSTDR 19 1 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0;Q15366-6;Q15366;H3BRU6;H3BSS4 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 1 22902400.0 5968800.0 8215600.0 8718000.0 True False 7825154.601941424 6989864.504157976 7815944.988961055 1.0 0.8932557706174633 0.998823075907269 22.89968782504366 -10.051508311391512 4.578294477806217 1.0000018046937504 0.9460394233909055 0.25836039319529513 0.043097671923987425 59711341.59838487 15.691012141035142 1543.7415511731062 0.01475347942885765 8.881609788104969e-11 10.051508311391512 -0.05396238130284492 QMSGAQIK(ub)IANPVEGSTDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QMSGAQIKIANPVEGSTDR 19 1 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0;Q15366-6;Q15366;H3BRU6;H3BSS4 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 1 27980700.0 7437600.0 8352100.0 12191000.0 True False 7201497.459136411 11687137.085626122 8997811.377839431 1.0 1.6228759576661185 1.2494361664217586 22.779865497024 -10.25962021417782 4.888403779003782 0.999895198724069 1.4361560620444025 0.6452372289230832 0.15245615636829404 0.00017417440431201123 2.6379757745835844e-05 0.14765029890092865 0.04920501288653789 5.500216515885802e-11 10.25962021417782 0.43626086332033354 QMSGAQIK(ub)IANPVEGSTDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QMSGAQIKIANPVEGSTDR 19 1 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0;Q15366-6;Q15366;H3BRU6;H3BSS4 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 1 55179000.0 11951000.0 20561000.0 22667000.0 True False 16369607.663631316 19652547.0338654 17313521.44151869 1.0 1.2005508890434715 1.0576625779483089 23.964516408838726 -10.358539400898236 4.024732804343899 0.999661747217853 1.1291067335010239 0.521195889847312 0.05833390874887151 0.00017751425806248063 2.829227079154247e-05 0.056628993676876564 0.01882718808963396 4.379863735266906e-11 10.358539400898236 0.12944498628317092 QMSGAQIK(ub)IANPVEGSTDR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 QMSGAQIKIANPVEGSTDR 19 1 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0;Q15366-6;Q15366;H3BRU6;H3BSS4 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 1 77277600.0 25725600.0 33986500.0 17565500.0 True False 21391976.2373155 33803407.97870795 21238364.836304396 1.0 1.5801909839326735 0.9928192047659838 24.35056643217849 -10.30381379783788 4.70781990498566 0.9998487786577963 1.2865050943498153 0.24083241325847105 0.2397935247131873 0.00038080240474249583 5.631300385559701e-05 0.23230099739253396 0.07739302731164298 4.968052792312505e-11 10.30381379783788 0.286656315692019 QMSGAQIK(ub)IANPVEGSTDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QMSGAQIKIANPVEGSTDR 19 1 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;Q15366-7;Q15366-8;F8VRH0;Q15366-6;Q15366;H3BRU6;H3BSS4 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 1 69617000.0 15405000.0 11988000.0 42224000.0 True False 19942076.17794795 11320857.26170108 34539665.25482628 1.0 0.5676869931035436 1.731999464179182 24.249312281355046 -6.806166320233427 1.430553916389852 0.763300661371472 1.750635730771209 0.8495806844838729 0.18637556848748463 0.21208103899701508 0.8560963627073592 0.1024617089615505 0.23745667941309584 1.562549124088253e-07 6.806166320233427 0.987335069399737 QMSLLLR ddPTM_RPMI8226_Bortezomib_1h_R1 2 QMSLLLR 7 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 93757700.0 34501700.0 29944800.0 29311200.0 False True 45232062.81493803 25477152.56391621 26278358.196884077 1.0 0.5632542709394696 0.5809674943280625 25.43084245600265 -10.221097276735357 8.328717481557169 1.0000001393383071 0.5721108826443044 0.9987163801323926 0.007231393166997581 1.871082580305484e-08 1.7537913174037692e-09 0.007001768621722862 0.0023339221088049815 6.010390968832759e-11 10.221097276735357 -0.4278892566940027 QMSLLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QMSLLLR 7 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 46141400.0 21402000.0 7050400.0 17689000.0 False True 20722605.224862516 9865661.487350278 13055720.241374912 1.0 0.47608210359157344 0.6300231124275316 24.30470205279196 -10.756214326569077 10.49503205474109 1.001235145016086 0.553052608009575 0.9182966076753973 0.06284615368956235 0.0018196771940174493 4.226857722327549e-05 0.06096437061879808 0.020283508884405558 1.7530151663001753e-11 10.756214326569077 -0.4481825370065109 QMSLLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QMSLLLR 7 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 102898000.0 34501700.0 34305000.0 34091300.0 False True 47257910.86338446 32789291.668535203 26039637.072362743 1.0 0.6938370966783557 0.5510111766819196 25.494052517525542 -13.999999999999998 0.10190549596222888 2.503918200628588 0.2555976046675148 0.9997841381596386 0.0027518252613289934 12.066181146238364 0.09544790286650824 3.7982924284888138 0.26319708018222765 1.0000000000000041e-14 13.999999999999998 -2.248320595961073 QMSLLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 QMSLLLR 7 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 52970730.0 24950400.0 19322000.0 8698330.0 False True 20747363.09013263 19217908.550883308 10517110.586466169 1.0 0.9262819794204726 0.5069131214784623 24.306424651344262 -6.936972103964017 0.6871523744799998 1.0050437755518928 0.4032315365667611 0.9977398426087577 0.01032418530962795 0.08917547829869885 0.06110550688644657 0.009832681826395741 0.0366016222758557 1.1561865051308706e-07 6.936972103964017 -0.6018122389851317 QMSLLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QMSLLLR 7 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 116687000.0 22582000.0 56330000.0 37775000.0 False True 29232844.15776831 53195185.98195037 30900337.60423132 1.0 1.8197061392609768 1.0570417793583007 24.80108686464158 -10.268851117871145 5.2458574561573466 0.9999359763974917 1.4383739593096998 0.30580413377398274 0.31135642112820816 0.000233174699162314 3.249907522665341e-05 0.3015134054154896 0.10048985281365874 5.384543404426781e-11 10.268851117871145 0.43843798291220815 QMTDPNVALTFLEK(ub)TR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QMTDPNVALTFLEKTR 16 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;E9PQG3 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 13364200.0 3082700.0 6321500.0 3960000.0 True False 4041449.552909261 5378356.8410140015 3550257.1870022686 1.0 1.3307989548310357 0.8784613393099501 21.946441408764272 -6.710658626110942 1.7928588824886595 1.2032299112195646 0.8795030305262101 0.4682413109785749 0.13938236631720058 0.37374708120985933 2.342236414630853 0.06185789747709358 0.15702263396786562 1.946889818324927e-07 6.710658626110942 -0.3237268806933544 QMTDPNVALTFLEK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QMTDPNVALTFLEKTR 16 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;E9PQG3 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 20687900.0 6510600.0 5773400.0 8403900.0 True False 6303924.566722264 8078748.727883272 6202666.478404126 1.0 1.2815427345895147 0.9839372937847848 22.587818840814716 -6.658662982900768 1.9772487926662103 1.1814180633309637 0.985169981067971 0.23013611577305038 0.11991153055066546 0.4875931315433636 3.6629465943205344 0.04901638406692271 0.13294150767714813 2.1945072355277074e-07 6.658662982900768 -0.19624808226299262 QMTDPNVALTFLEK(ub)TR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QMTDPNVALTFLEKTR 16 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;E9PQG3 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 36658000.0 8319000.0 16082000.0 12257000.0 True False 12620531.200365191 13212041.45076048 9834398.577566063 1.0 1.0468688869750722 0.7792380860546894 23.589269299096518 -6.861706949639805 1.1771718319086857 1.0255508235432327 0.7658547801597729 0.9556766273528166 0.024567859175348393 0.14504831994939688 0.38098367408867273 0.016266937659691682 0.03804547944021487 1.3749694548593774e-07 6.861706949639805 -0.25969604338345975 QMTDPNVALTFLEK(ub)TR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QMTDPNVALTFLEKTR 16 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;E9PQG3 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 15714700.0 3082700.0 7482000.0 5150000.0 True False 4222457.496835092 7151420.500334658 3933676.0675793546 1.0 1.6936631110425493 0.9316082093254482 22.009651470287164 -6.667180096984364 1.9479997851629804 1.4438414306121263 0.9347633821231512 0.2664218799096447 0.2948474318090762 0.46757778520184634 3.418143708008113 0.12198951841705813 0.3270535732673379 2.1518891856906646e-07 6.667180096984364 -0.5090780484889751 QMTDPNVALTFLEK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 QMTDPNVALTFLEKTR 16 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;E9PQG3 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 28701200.0 9285600.0 13042000.0 6373600.0 True False 7721387.821827932 12971740.157365678 7706290.291803231 1.0 1.6799752138722126 0.9980447128970752 22.88042874631528 -10.238566687727046 4.2796800017542145 0.999829710829063 1.339009963394187 0.24784955500851003 0.27839696143890974 196447017.03282824 118.4769142535985 361720.5313592508 0.09530268479398878 5.773422126050376e-11 10.238566687727046 0.33918025256512396 QMTDPNVALTFLEK(ub)TR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 QMTDPNVALTFLEKTR 16 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;E9PQG3 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 48261200.0 14694700.0 18373100.0 15193400.0 True False 19022578.82584174 17350620.83374708 12428357.097448787 1.0 0.912106659806643 0.653347646038672 24.181209504892497 -6.951873314613989 0.5378834476723262 1.0038635442578412 0.5496844824290175 0.9993402190885504 0.0037794409165986353 0.08274209542738178 0.03291567499848756 0.004169145374464106 0.021421829362195048 1.1171890886470647e-07 6.951873314613989 -0.4541790618288237 QMTDVLLTPATDALK(ub)NR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QMTDVLLTPATDALKNR 17 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9;H3BMX0;H3BP95 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 19555500.0 0.0 8727500.0 10828000.0 True False 0.0 7425391.019528552 9707622.429510254 0.0 QMTDVLLTPATDALK(ub)NR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QMTDVLLTPATDALKNR 17 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9;H3BMX0;H3BP95 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 34231700.0 8242700.0 10084000.0 15905000.0 True False 7981040.000325866 14110593.787365297 11739003.360227706 1.0 1.7680144175181631 1.4708613613950565 22.92814532398614 -10.130327881718575 4.61789053065418 0.9999439408884073 1.6194378894664827 0.8528099673144198 0.1213122272232988 84697358.77980886 6.426666710184362 53761.703157975215 0.04152840208621622 7.407507814040912e-11 10.130327881718575 0.6194939485780754 QMTDVLLTPATDALK(ub)NR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QMTDVLLTPATDALKNR 17 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9;H3BMX0;H3BP95 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 114385000.0 20198000.0 25263000.0 68924000.0 True False 30641842.6715923 20754620.26928009 55301141.189537585 1.0 0.6773293790363809 1.8047589951503353 24.86899972169744 -6.830192412442756 1.326982165232887 0.8276065658513625 1.8352311582241865 0.9062706803013669 0.14514377519439475 0.1805744527727396 0.621789173047393 0.08587668921314227 0.19763242404561482 1.4784532202256293e-07 6.830192412442756 1.007624592372824 QMTDVLLTPATDALK(ub)NR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QMTDVLLTPATDALKNR 17 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9;H3BMX0;H3BP95 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 27741000.0 0.0 16319000.0 11422000.0 True False 0.0 15597972.620283524 8724358.84347406 0.0 QMTDVLLTPATDALK(ub)NR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QMTDVLLTPATDALKNR 17 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9;H3BMX0;H3BP95 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 30613500.0 8242700.0 13559000.0 8811800.0 True False 6854170.263524282 13485954.975749211 10654306.63884015 1.0 1.9675547086300413 1.5544269005891185 22.708550599420416 -10.147994219640792 4.506242338206113 0.999890218491052 1.7609908046121985 0.8189738419661566 0.16865872144094385 117958923.08946998 29.00178830053967 134833.00054054527 0.05773636639853055 7.112229798038627e-11 10.147994219640792 0.7611005861211465 QMTDVLLTPATDALK(ub)NR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 QMTDVLLTPATDALKNR 17 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9;H3BMX0;H3BP95 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 149910900.0 26454600.0 24274000.0 99182300.0 True False 34246001.19812674 22923130.561439108 81132139.0963375 1.0 0.6693666343354857 2.3690981795788595 25.02943220298729 -6.856244317809524 1.2044849147756544 0.8220972687525507 2.445724320290688 0.948913073936746 0.16631235351589235 0.15072805463189784 0.4176661479689658 0.1078412694944901 0.2507760805614064 1.3923732855164783e-07 6.856244317809524 1.6236270515381372 up QMVETELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QMVETELK 8 0 P62258;P62258-2;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 0 10234800.0 1057700.0 5532500.0 3644600.0 False True 1386654.9427813697 4707072.565516088 3267491.7534718313 1.0 3.3945521847523104 2.356384167872258 20.40317739932803 -10.546319698856205 6.649670903252836 0.9981957987007715 2.875468176312284 0.8131308556533164 0.42383031810554017 0.011338713862370202 0.0007735941159287395 0.41045205242146604 0.1367906469700456 2.8423679739332033e-11 10.546319698856205 1.8772723776115126 QMVETELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QMVETELK 8 0 P62258;P62258-2;K7EIT4 P62258 YWHAE 14-3-3 protein epsilon 0 9964100.0 1057700.0 4179700.0 4726700.0 False True 1448760.2732677457 3995027.033580429 3610350.809442206 1.0 2.757548717545561 2.4920277537006816 20.46638746085092 -10.179026435653828 4.826694832117111 0.9998229043894585 2.6247882356289693 0.9803640134513758 0.10839847959213911 0.00020659904575724559 3.5140624888998164e-05 0.10496739835464591 0.03498545884834692 6.62176195583217e-11 10.179026435653828 1.624965331239511 QMVIDVLHPGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QMVIDVLHPGK 11 0 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4 E7ETK0 RPS24 40S ribosomal protein S24 0 15942800.0 7140600.0 2792800.0 6009400.0 False True 6913925.56156683 3907979.6042595957 4435357.861864347 1.0 0.5652331037498142 0.6415107918603637 22.721073640304223 -10.765334679883486 7.028083265828572 1.0088947965262949 0.603371947805089 0.9730097649947955 0.031140235771667593 0.00434734355195952 0.00014515614078476776 0.03020193868946396 0.010050467878386763 1.7165850272638034e-11 10.765334679883486 -0.4055228487212059 QMVIDVLHPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QMVIDVLHPGK 11 0 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4 E7ETK0 RPS24 40S ribosomal protein S24 0 33667600.0 8123600.0 12084000.0 13460000.0 False True 11127114.452035429 11550088.923555752 10281025.217401575 1.0 1.0380129523555814 0.9239614872048806 23.40757617733397 -6.816836471624194 1.385384792762352 1.0205567717901372 0.9216341526741364 0.8769803122650766 0.01663079820784275 0.1976232960576216 0.7461156796702839 0.00943515539668071 0.02176826403263107 1.5246267256280494e-07 6.816836471624194 -0.09892261911600075 QNFLLFDMTTHPLTNNNIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QNFLLFDMTTHPLTNNNIK 19 0 Q9H4A6 Q9H4A6 GOLPH3 Golgi phosphoprotein 3 0 4091620.0 787120.0 2131000.0 1173500.0 False True 1031921.9424809221 1813063.10657294 1052077.4770068582 1.0 1.756976988214842 1.019532034058195 19.97690241464468 -10.401742180233239 4.422742628748356 0.9991226434545607 1.3882545111376352 0.269851001637612 0.30106064184944387 215825053.18468362 2330.8687013079266 1928346.5166320873 0.10306034328888208 3.965133553263564e-11 10.401742180233239 0.3891318676830745 QNFLLFDMTTHPLTNNNIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QNFLLFDMTTHPLTNNNIK 19 0 Q9H4A6 Q9H4A6 GOLPH3 Golgi phosphoprotein 3 0 7591200.0 2367200.0 2255700.0 2968300.0 False True 2292054.53173977 3156412.773320104 2190813.1829087664 1.0 1.377110679353797 0.9558294327516907 21.12820993791055 -6.670733572829239 1.9350396982051765 1.240558148036375 0.9575360423030643 0.2822265930546741 0.16016159819680031 0.45940944297438213 3.317171069370386 0.06662147434454303 0.17780848040723932 2.1343538763014154e-07 6.670733572829239 -0.28302210573331066 QNFLLFDMTTHPLTNNNIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QNFLLFDMTTHPLTNNNIK 19 0 Q9H4A6 Q9H4A6 GOLPH3 Golgi phosphoprotein 3 0 6237620.0 787120.0 1887700.0 3562800.0 False True 1078139.5351181882 1804295.1722108729 2721340.018169271 1.0 1.673526583006792 2.524107436493321 20.04011247616757 -6.967958879609356 0.30300243758177103 0.8576467492383109 3.3667537986255467 0.9999617968888173 0.003854459314022334 0.07697074726403172 0.011388351007149137 0.013905492693854358 0.0760456600623692 1.0765671416247088e-07 6.967958879609356 2.509107049387236 QNGHIK(ub)FLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QNGHIKFLTK 10 1 H0YNG3;P67812-2;P67812-4;P67812;P67812-3;H0YKT4;H0YNX5;P0C7V7 H0YNG3;P0C7V7 SEC11A;SEC11B Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11A;Putative signal peptidase complex catalytic subunit SEC11B 1 4088370.0 647850.0 901120.0 2539400.0 True False 849337.6237883243 766676.4085382479 2276647.247644839 1.0 0.9026756699163045 2.6804973474391085 19.695978634033775 -6.893954412463168 0.9986798677712113 0.9133328297023079 2.8458092353957234 0.9833115356549786 0.10542711041080952 0.1159939077596661 0.20356736619847218 0.07998798432408226 0.2024733818678251 1.276572802582401e-07 6.893954412463168 1.9324764056934156 up QNGHIK(ub)FLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QNGHIKFLTK 10 1 H0YNG3;P67812-2;P67812-4;P67812;P67812-3;H0YKT4;H0YNX5;P0C7V7 H0YNG3;P0C7V7 SEC11A;SEC11B Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11A;Putative signal peptidase complex catalytic subunit SEC11B 1 5149330.0 647850.0 719180.0 3782300.0 True False 887377.6524879544 687404.249589773 2888998.6389136687 1.0 0.7746467895179545 3.2556585471966066 19.759188695556666 -6.884714157735134 1.0531890743907197 0.8493148362583837 3.4481642007394795 0.9772920519001002 0.16880892617047125 0.1235348694800414 0.2477629924271537 0.12290137791196595 0.30109786078327927 1.30402477405489e-07 6.884714157735134 2.598849364481096 up QNGHIK(ub)FLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QNGHIKFLTK 10 1 H0YNG3;P67812-2;P67812-4;P67812;P67812-3;H0YKT4;H0YNX5;P0C7V7 H0YNG3;P0C7V7 SEC11A;SEC11B Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11A;Putative signal peptidase complex catalytic subunit SEC11B 1 7486800.0 795600.0 1999900.0 4691300.0 True False 661576.6510560764 1989126.1417509299 5672229.139879577 1.0 3.0066450177400954 8.573804911078684 19.33554879298465 -6.953194189054824 0.5226032735344874 0.9072668721586795 10.922733118375048 0.9994286906624954 0.0765788886136517 0.08222793675059721 0.030846325572108223 0.08639895416085912 0.45997285539628 1.1137964028488471e-07 6.953194189054824 10.015466246216368 QNGTVYTCSSDGK(ub)VR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QNGTVYTCSSDGKVR 15 1 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 5761400.0 2035600.0 1888700.0 1837100.0 True False 2668691.312778438 1606913.3220949362 1647014.5147075425 1.0 0.6021353291782332 0.6171618676244711 21.347701008082794 -9.778892223143322 6.283372789724591 1.0000000082942957 0.6096485984116933 0.9988898398051409 0.006134558633325242 7.150337277689666e-10 1.4086278453130994e-10 0.005939761032351659 0.001979920285111026 1.6638255030343142e-10 9.778892223143322 -0.3903514098826024 QNGTVYTCSSDGK(ub)VR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QNGTVYTCSSDGKVR 15 1 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 17897000.0 4745000.0 0.0 13152000.0 True False 7198511.905966196 0.0 10552501.43527361 1.0 0.0 1.4659281769788552 22.779267269244354 -6.723078381080146 1.7484141450823787 0.39360261360691223 1.464016172811764 0.5268763468413942 0.42065432266535147 0.3493951700023093 2.089021719274087 0.1909195537660761 0.4775211246858064 1.8920021209766039e-07 6.723078381080146 1.0704135592048518 QNGTVYTCSSDGK(ub)VR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QNGTVYTCSSDGKVR 15 1 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 21915200.0 4745000.0 4226200.0 12944000.0 True False 6142496.037933333 3991008.2548716315 10588324.81665573 1.0 0.6497372127267048 1.723782115815286 22.550393591336803 -6.818875273549047 1.3767059993492343 0.8109917898516684 1.7466738040361998 0.881781006254667 0.15377039993851876 0.1949485526061869 0.7263260679887429 0.08777855752879794 0.20238137047308452 1.5174861166791916e-07 6.818875273549047 0.9356820141845313 QNHVVDVSVAVSTPAGLITPIVFNAHIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QNHVVDVSVAVSTPAGLITPIVFNAHIK 28 0 P10515;H0YDD4;E9PEJ4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 28081500.0 5358700.0 13594000.0 9128800.0 False True 8129539.673445965 11168044.489593223 7324488.6787048215 1.0 1.3737609924055256 0.900972130393713 22.95474223286204 -6.695988922087749 1.8452607099751688 1.2329960423012138 0.9024827377879442 0.39856143697357005 0.15788761663568968 0.4039064397290368 2.670890205303366 0.06833660774594973 0.17661346506490022 2.0137756162646386e-07 6.695988922087749 -0.33051330451326966 QNIEDK(ub)VHMPMDCINIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QNIEDKVHMPMDCINIR 17 1 A0A0A0MSE9;B7WPA5;Q96CS7-5;Q96CS7-3;Q96CS7;Q96CS7-6;Q96CS7-2;A0A0A0MSI4;Q96CS7-4 A0A0A0MSE9 PLEKHB2 Pleckstrin homology domain-containing family B member 2 1 187153900.0 5332900.0 76715000.0 105106000.0 True False 8090399.187213311 63024608.87296925 84331753.03040363 1.0 7.790049343001293 10.423682574734757 22.947779457542463 -8.839738961395122 0.4341836347182837 1.6737670755969303e-13 10.766327710218416 0.9968262079845922 0.22365438765157117 0.36735197584282736 0.15576897331209033 1.355164722455441 0.6082296781723405 1.44630883313325e-09 8.839738961395122 10.766327710218249 QNIEDK(ub)VHMPMDCINIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QNIEDKVHMPMDCINIR 17 1 A0A0A0MSE9;B7WPA5;Q96CS7-5;Q96CS7-3;Q96CS7;Q96CS7-6;Q96CS7-2;A0A0A0MSI4;Q96CS7-4 A0A0A0MSE9 PLEKHB2 Pleckstrin homology domain-containing family B member 2 1 186414900.0 5332900.0 96166000.0 84916000.0 True False 6903544.177174857 90814277.56329209 69462159.31173806 1.0 13.154732588450834 10.061811372396274 22.718905779634913 -9.587141613514108 10.31700284641611 0.9999631478164828 11.608271980423554 0.9400666786099897 1.2626797991729457 0.0 2.5552140280864856e-18 1.2225844583663383 0.4075281527887794 2.5873690956019077e-10 9.587141613514108 10.608308832607072 QNIGVATFIGLDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QNIGVATFIGLDK 13 0 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 18675500.0 4176100.0 9726400.0 4773000.0 False True 6335449.013805162 7990647.92728994 3829614.4579197858 1.0 1.2612599217321523 0.6044740395787139 22.595015440787176 -6.798743308684127 1.4608624959263223 1.144376672223832 0.5956668899245627 0.828532519880061 0.11180034338592167 0.22254281606990003 0.9377326612228071 0.06020800289532056 0.14014111875970503 1.5894859423978183e-07 6.798743308684127 -0.5487097822992693 QNIGVATFIGLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QNIGVATFIGLDK 13 0 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 13940500.0 4176100.0 6061800.0 3702600.0 False True 5406043.773237817 5724455.501249542 3028764.7918842337 1.0 1.058899213799932 0.5602553214381817 22.366141762879625 -6.877438912047319 1.094022369557252 1.0354005745817567 0.5266128117872665 0.9715584417846533 0.03752101048555371 0.1299210219309017 0.28622296348531634 0.02647798256685092 0.0636320937835586 1.3260536276236714e-07 6.877438912047319 -0.5087877627944902 QNLFLGSLTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QNLFLGSLTSR 11 0 Q3ZCQ8;Q3ZCQ8-2;M0R0C3;M0R2F8;Q3ZCQ8-3 Q3ZCQ8 TIMM50 Mitochondrial import inner membrane translocase subunit TIM50 0 9417400.0 2811800.0 2485800.0 4119800.0 False True 3686297.029509932 2114928.3295725076 3693522.6159121073 1.0 0.5737270525521577 1.0019601205069295 21.81374089252721 -10.898705639350744 10.855941602906707 1.0168659377776292 0.7878435865297004 0.24656715084354897 0.17482541791263087 0.06543068655727954 0.000610518009863206 0.1551983280310483 0.056424661005780946 1.2626830791414615e-11 10.898705639350744 -0.2290223512479288 QNLFLGSLTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QNLFLGSLTSR 11 0 Q3ZCQ8;Q3ZCQ8-2;M0R0C3;M0R2F8;Q3ZCQ8-3 Q3ZCQ8 TIMM50 Mitochondrial import inner membrane translocase subunit TIM50 0 7646400.0 2811800.0 2069900.0 2764700.0 False True 3851398.4460378624 1978444.9737560425 2111734.8007838144 1.0 0.5136952204442451 0.5483033839192275 21.876950954050102 -10.082634748101057 5.452098017271219 1.0000046731322667 0.5309993021814956 0.995932744298853 0.01412872357560146 8.025730448560612e-07 1.3503342858860074e-07 0.013680214002964583 0.004560025925833504 8.267329591876109e-11 10.082634748101057 -0.4690053709507711 QNLFTTWSHHLQQANIQFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QNLFTTWSHHLQQANIQFR 19 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y6H2;A0A2R8YFZ7;H0YJ21 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 7608500.0 1160300.0 4286400.0 2161800.0 False True 1521164.5363611823 3646885.8282563323 1938117.6734498763 1.0 2.3974302194686605 1.2741012738083537 20.536744779555562 -6.59179818884879 2.2219217024470543 1.9447320770266037 1.2774283272618956 0.0 0.6052738658899969 0.6642760870447695 6.18529088817694 0.2271717750742804 0.6743959722032441 2.5597751056830867e-07 6.59179818884879 -0.6673037497647081 QNLFTTWSHHLQQANIQFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QNLFTTWSHHLQQANIQFR 19 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y6H2;A0A2R8YFZ7;H0YJ21 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 29075800.0 9886400.0 8625400.0 10564000.0 False True 9572561.643541755 12069567.200866781 7796971.486793173 1.0 1.2608502979983065 0.8145125387678745 23.19047361481963 -6.748271417099354 1.6560443014690944 1.1536970521240961 0.813729538785037 0.6416047021749357 0.10960313746884254 0.30305752810270775 1.6346709313472314 0.05229240422309048 0.12719293091099232 1.7853714386569215e-07 6.748271417099354 -0.33996751333905917 QNLFTTWSHHLQQANIQFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QNLFTTWSHHLQQANIQFR 19 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y6H2;A0A2R8YFZ7;H0YJ21 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 33383900.0 1160300.0 6608600.0 25615000.0 False True 1589294.2659284908 6316610.200282235 19565264.557484493 1.0 3.9744749199053904 12.310662019568891 20.599954841078453 -6.952970376191903 0.5252242252530276 0.863852267251985 15.79663517907004 0.9994142351551153 0.11586681092700937 0.08231449342943309 0.031192569504198367 0.13019696650558224 0.6889565324899357 1.1143705437061658e-07 6.952970376191903 14.932782911818055 QNLFTTWSHHLQQANIQFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QNLFTTWSHHLQQANIQFR 19 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y6H2;A0A2R8YFZ7;H0YJ21 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 35183500.0 9886400.0 10326000.0 14971100.0 False True 8220979.6417807825 10270371.788449483 18101487.791454654 1.0 1.2492880697883315 2.2018650550427115 22.970878890253907 -6.945926104298395 0.6019103806090126 0.9893140586742044 2.5107621145395718 0.9988415608647568 0.01762732451528548 0.08516403333016628 0.043058762123805924 0.018057753049453763 0.08010236073802857 1.1325930588426002e-07 6.945926104298395 1.5214480558653674 up QNLLSQSHAYQQFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QNLLSQSHAYQQFLR 15 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 11893100.0 2774100.0 2305600.0 6813400.0 False True 2686037.7139655696 3226238.103545167 5028766.142381352 1.0 1.2011142236651864 1.8721874664064424 21.357048130742218 -6.949037450128286 0.5693113526230986 0.9916144066010961 2.1142758984716776 0.9991235776756867 0.011039523888814108 0.08387454396556569 0.037579599912081284 0.011704906064960295 0.055904193194168596 1.1245080010914883e-07 6.949037450128286 1.1226614918705815 QNLLSQSHAYQQFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QNLLSQSHAYQQFLR 15 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 12641900.0 1856600.0 4675600.0 6109700.0 False True 2543035.1927284673 4469016.531858424 4666714.693221285 1.0 1.7573553620638405 1.8350963866191268 21.278119996756644 -11.188893930675842 0.399555313563243 1.9357680694965954e-20 1.8409891324539196 0.9995811420889551 0.007709217308595977 3.1983645687299918 0.19802238362153052 2.8799921268918114 0.019878408261526478 6.47300689050846e-12 11.188893930675842 1.8409891324539196 QNLLSQSHAYQQFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QNLLSQSHAYQQFLR 15 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 7409800.0 2774100.0 2397900.0 2237800.0 False True 2306787.0634673983 2384982.036754117 2705713.6335818497 1.0 1.0338977855932578 1.172936018426778 21.137453406176494 -6.944298117630192 0.6182850164728791 0.9984763143281954 1.2157018504128947 0.9986743981227663 0.0027242438281916744 0.0858593356958911 0.04608322730694238 0.0027478307653721716 0.011759287141817523 1.1368466395359578e-07 6.944298117630192 0.2172255360846993 QNLQLCVQVASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QNLQLCVQVASK 12 0 A0A087WX41;P53675-2;P53675 A0A087WX41 CLTCL1 Clathrin heavy chain 2 0 28774500.0 5356300.0 9371200.0 14047000.0 False True 8125898.697982463 7698836.142480214 11270604.292981189 1.0 0.9474442678434716 1.386997883173157 22.954095948558532 -6.877047606929225 1.0961748694457873 0.9685432751906954 1.4164324469292164 0.9712229989507796 0.03324867470457614 0.13027543328248828 0.28838705673729237 0.023424437901809526 0.056243121033281634 1.3272489580442122e-07 6.877047606929225 0.44788917173852105 QNLQLCVQVASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QNLQLCVQVASK 12 0 A0A087WX41;P53675-2;P53675 A0A087WX41 CLTCL1 Clathrin heavy chain 2 0 18802300.0 5356300.0 8339400.0 5106600.0 False True 6933835.938457819 7875305.059078242 4177251.198140769 1.0 1.1357789727037901 0.6024444817005358 22.72522227065098 -6.83918934328459 1.286088901959018 1.07224179908598 0.5851749873691823 0.9230638247087551 0.06277149457812546 0.1697457640510856 0.5457263958908463 0.03827631162873003 0.0881661994111498 1.4481403570748592e-07 6.83918934328459 -0.4870668117167978 QNLVIMGK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 QNLVIMGKK 9 1 P00374;B4DM58 P00374 DHFR Dihydrofolate reductase 1 8148540.0 1639340.0 1400900.0 5108300.0 True False 1587300.0490293498 1960286.6755969885 3770282.984284892 1.0 1.2349818024611816 2.3752805820112326 20.598143437465936 -6.940475558970309 0.6551355250454826 0.9872977527007306 2.687121461482398 0.9982253928279441 0.02530252918612422 0.08755056535038659 0.05362899087840498 0.02471960561908306 0.09793953595308572 1.1468970641638953e-07 6.940475558970309 1.6998237087816674 up QNLVIMGK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 QNLVIMGKK 9 1 P00374;B4DM58 P00374 DHFR Dihydrofolate reductase 1 30620600.0 1606600.0 2286000.0 26728000.0 True False 2437329.6581928986 1878045.439400477 21445199.084701456 1.0 0.7705340281268764 8.798645276651456 21.21686996362528 -6.900322598037394 0.959252915157751 0.66916878924005 9.646793530919618 0.9867253660426659 0.4299360302639532 0.11116730848999419 0.17609515354738028 0.33595573394929923 0.8754968368791787 1.257990617354233e-07 6.900322598037394 8.977624741679568 up QNLVIMGK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QNLVIMGKK 9 1 P00374;B4DM58 P00374 DHFR Dihydrofolate reductase 1 4702790.0 531990.0 1149400.0 3021400.0 True False 728681.0794891821 1098615.707442484 2307807.5476862644 1.0 1.50767700488756 3.167102334129599 19.47492800543433 -6.9495080942651555 0.5642170123016828 0.9787571133728863 3.7759052029283193 0.9991621217606885 0.026787569307866313 0.08368384913055314 0.03678431118975806 0.028570663208104707 0.13807317748288808 1.1232900338980496e-07 6.9495080942651555 2.7971480895554333 QNNK(ub)QAFDGFAALGVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QNNKQAFDGFAALGVSR 17 1 Q8N3D4;E9PIH6;H0YDZ9;A0A0U1RQH4 Q8N3D4 EHBP1L1 EH domain-binding protein 1-like protein 1 1 26429000.0 6551600.0 4419400.0 15458000.0 True False 9939256.186117625 3630723.5410701977 12402719.524517909 1.0 0.365291272614676 1.2478518806911383 23.244706459667917 -6.713663773422361 1.781925887700784 0.6112867807539563 1.2460384056592924 0.4827052290079985 0.26731178553081497 0.3676952139688387 2.2780307272780043 0.11927441132363373 0.3016992978819396 1.933464607290544e-07 6.713663773422361 0.6347516249053361 QNPFWWTHQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QNPFWWTHQR 10 0 Q6P2Q9;I3L3Z8 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 9312500.0 2501300.0 2556600.0 4254600.0 False True 3279228.5226236605 2175165.2455487484 3814374.805005016 1.0 0.6633161521199602 1.1631927383801826 21.644925012978895 -6.725255292768644 1.7405168390069812 0.7963245851386073 1.162648693922959 0.5371732962520006 0.14159397909180113 0.3451898302807858 2.0463575791114232 0.06452777766496591 0.1609894083619799 1.8825421431671962e-07 6.725255292768644 0.36632410878435173 QNPGLAYGNPYSGIQESSSPSPLSIK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 QNPGLAYGNPYSGIQESSSPSPLSIKK 27 1 Q13137-5;Q13137-2;Q13137;Q13137-3;Q13137-4 Q13137-5 CALCOCO2 Calcium-binding and coiled-coil domain-containing protein 2 1 36424100.0 14581000.0 12856000.0 8987100.0 True False 19115832.202604875 10937934.912295494 8057201.102350526 1.0 0.5721924526416906 0.42149360890772974 24.18826467309121 -13.999999999999998 0.14541040132772057 3.055415422705859 0.24661589859577637 0.9995822723088389 0.005008208391442528 11.94342074150863 0.11983874626564574 6.947342209920336 0.1569756339482813 1.0000000000000041e-14 13.999999999999998 -2.808799524110083 QNPGLAYGNPYSGIQESSSPSPLSIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 QNPGLAYGNPYSGIQESSSPSPLSIKK 27 1 Q13137-5;Q13137-2;Q13137;Q13137-3;Q13137-4 Q13137-5 CALCOCO2 Calcium-binding and coiled-coil domain-containing protein 2 1 60810000.0 22240000.0 18548000.0 20022000.0 True False 21534003.373560496 25954313.12654219 14777637.552875156 1.0 1.2052711554048032 0.6862466442732695 24.36011321921486 -6.799407567714215 1.4583455910515988 1.1133431377522334 0.6791877512926621 0.8304163389434358 0.08789082356196529 0.2216075790251403 0.9305428175193154 0.04741366712214611 0.1103059854264138 1.587056661362053e-07 6.799407567714215 -0.4341553864595713 QNPGLAYGNPYSGIQESSSPSPLSIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QNPGLAYGNPYSGIQESSSPSPLSIKK 27 1 Q13137-5;Q13137-2;Q13137;Q13137-3;Q13137-4 Q13137-5 CALCOCO2 Calcium-binding and coiled-coil domain-containing protein 2 1 69676000.0 22240000.0 35551000.0 11885000.0 True False 18493545.399053697 35359479.706679 14370098.549968846 1.0 1.9119903157394755 0.7770331886012595 24.140518494649136 -6.6928041954394635 1.8563923611845172 1.5702601589375065 0.7808201335818704 0.38354394817873816 0.3854929681050049 0.41070716026648496 2.746278767149731 0.1659867499498013 0.43072887955811484 2.0285971199005323e-07 6.6928041954394635 -0.7894400253556361 QNPLLAEAYSNLGNVYK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 QNPLLAEAYSNLGNVYKER 19 1 O15294;O15294-3;C9JZL3 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 8513000.0 1246100.0 2752300.0 4514600.0 True False 1633649.1672495669 2341667.568381371 4047472.4991011247 1.0 1.4333968488006719 2.4775653060904763 20.63966676148975 -6.956248999863728 0.485419847856136 0.9761716328880612 2.978725619858821 0.9996047921268607 0.012328560104239326 0.08106929672038399 0.02629694949057578 0.01488812318685014 0.08612309153453292 1.1059894904145748e-07 6.956248999863728 2.00255398697076 up QNPLLAEAYSNLGNVYK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 QNPLLAEAYSNLGNVYKER 19 1 O15294;O15294-3;C9JZL3 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 21010800.0 4557700.0 6148100.0 10305000.0 True False 4413018.308258847 8603068.391917944 7605811.356626622 1.0 1.9494748924602303 1.7234941768522798 22.07333430194953 -10.156262124742739 5.766173167727769 0.999988592402576 1.836484534656286 0.9481028346110513 0.09225624082487215 1.3533413867486637e-05 1.9804429520141383e-06 0.08932793825969629 0.02977557369151752 6.978111029217761e-11 10.156262124742739 0.8364959422537099 QNPLLAEAYSNLGNVYK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 QNPLLAEAYSNLGNVYKER 19 1 O15294;O15294-3;C9JZL3 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 64865000.0 13007000.0 29327000.0 22531000.0 True False 19732569.939073205 24093367.717103165 18077737.974311892 1.0 1.220994923190161 0.9161370277733303 24.23407552685726 -6.712289168161244 1.787382838225314 1.135544850451937 0.9168137706819013 0.4758611735258871 0.09309323051155974 0.37046830877795317 2.308585146817405 0.041429005424151205 0.10494471963934039 1.9395939993441926e-07 6.712289168161244 -0.2187310797700357 QNPLLAEAYSNLGNVYK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QNPLLAEAYSNLGNVYKER 19 1 O15294;O15294-3;C9JZL3 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 10854000.0 1246100.0 1959900.0 7648000.0 True False 1706816.84458631 1873305.1374774002 5841699.915504262 1.0 1.0975431508185303 3.4225698756331084 20.70287682301264 -6.915715198384842 0.8558960429457586 0.9403597140273089 3.762894915266837 0.9929056831617491 0.0943121544769907 0.10075905919123374 0.11916121967486608 0.07946685146340927 0.2291088393381491 1.2141848275133102e-07 6.915715198384842 2.8225352012395284 up QNPLLAEAYSNLGNVYK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QNPLLAEAYSNLGNVYKER 19 1 O15294;O15294-3;C9JZL3 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 16838600.0 4557700.0 5278100.0 7002800.0 True False 3789929.4903447437 5249665.827679175 8467053.10271113 1.0 1.3851618720224923 2.2340925139324797 21.853739577383806 -6.9581013354507855 0.4614201717366712 0.9756029997312373 2.6779546688206888 0.9996931494819552 0.009030758722523409 0.08038655697477684 0.02369166067987505 0.011557517415305635 0.07011952650649574 1.1012823135047853e-07 6.9581013354507855 1.7023516690894516 up QNPLLAEAYSNLGNVYK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QNPLLAEAYSNLGNVYKER 19 1 O15294;O15294-3;C9JZL3 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 47942000.0 13007000.0 23280000.0 11655000.0 True False 16837817.906301137 21984447.535235293 9533909.59039885 1.0 1.305658943312848 0.5662200199249702 24.00520184894971 -6.794449864182986 1.478537941490426 1.1698478342085794 0.5573648097648888 0.8154230986488291 0.1303399663489964 0.2287735168553451 0.9878345148053504 0.06937215952328481 0.16190465123156697 1.605277563828909e-07 6.794449864182986 -0.6124830244436906 QNRPIPQWIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QNRPIPQWIR 10 1 Q59GN2;P62891 Q59GN2 RPL39P5;RPL39 Putative 60S ribosomal protein L39-like 5;60S ribosomal protein L39 0 52136600.0 5278600.0 21196000.0 25662000.0 False True 6920295.71803512 18033639.421360865 23006742.407285888 1.0 2.6059058971082756 3.324531688339208 22.722402257739244 -9.29554145912352 0.2562998301634078 1.1596369206920324e-12 3.761909360447307 0.9990530213506533 0.029903894140845728 0.7095186884981313 0.09653543454554546 0.9096847924945247 0.3007909720137186 5.06359008585553e-10 9.29554145912352 3.7619093604461473 QNRPIPQWIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QNRPIPQWIR 10 1 Q59GN2;P62891 Q59GN2 RPL39P5;RPL39 Putative 60S ribosomal protein L39-like 5;60S ribosomal protein L39 0 83237000.0 14866000.0 0.0 68371000.0 False True 14394086.967236975 0.0 50462584.01396599 1.0 0.0 3.5057856833035768 23.77897294428238 -6.830460465011791 1.3257206396449717 0.4658148148853296 3.601098384618974 0.9068114536915968 0.45014229905054853 0.18024762580859757 0.6193792500559635 0.26657456719804723 0.6134976229289949 1.477540979974739e-07 6.830460465011791 3.1352835697336445 QNRPIPQWIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QNRPIPQWIR 10 1 Q59GN2;P62891 Q59GN2 RPL39P5;RPL39 Putative 60S ribosomal protein L39-like 5;60S ribosomal protein L39 0 173807000.0 15016000.0 146130000.0 12661000.0 False True 22780369.81664668 120051959.78109892 10158547.800486557 1.0 5.269974137705672 0.44593427948053904 24.441287832166758 -6.673105259550559 1.92614006679272 3.7182551335884466 0.46510236481230804 0.2928418941308899 1.8125184360030193 0.45410991101139014 3.250877691474274 0.756728793928344 2.0138040096446814 2.1227299155678967e-07 6.673105259550559 -3.253152768776139 QNRPIPQWIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QNRPIPQWIR 10 1 Q59GN2;P62891 Q59GN2 RPL39P5;RPL39 Putative 60S ribosomal protein L39-like 5;60S ribosomal protein L39 0 55230600.0 5278600.0 20553000.0 29399000.0 False True 7230241.068801296 19644900.50031787 22455561.691410795 1.0 2.7170464045917084 3.1057832619588863 22.785612319262135 -10.049386588412096 0.35396689247382407 1.5045155184375137e-25 3.1824088645175443 0.9988671625675846 0.030794016909104095 1.4207318151941697 0.15933725028872742 1.5623427014440527 0.11334868050442085 8.925106592418619e-11 10.049386588412096 3.1824088645175443 QNRPIPQWIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QNRPIPQWIR 10 1 Q59GN2;P62891 Q59GN2 RPL39P5;RPL39 Putative 60S ribosomal protein L39-like 5;60S ribosomal protein L39 0 144235000.0 15016000.0 53183000.0 76036000.0 False True 19438508.00961159 50223319.29838577 62198228.195243835 1.0 2.5837023743567293 3.1997429105407273 24.212414154259207 -9.548946988967817 0.2724007996861065 1.6033086716750482e-23 3.507205195882696 0.9989221422090259 0.030419392599670143 0.9408400890447022 0.11063826257809288 1.0609036630615485 0.24320294125744665 2.825224807625509e-10 9.548946988967817 3.507205195882696 QNSLTQFMSIPSSVIHPAMVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QNSLTQFMSIPSSVIHPAMVR 21 0 A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2;H7C2L8;A0A087WW69 A0A087WTA5 EIF2B4 Translation initiation factor eIF-2B subunit delta 0 4464070.0 998670.0 1904000.0 1561400.0 False True 1309266.0411340378 1619930.62173387 1399841.3060063983 1.0 1.2372814774381118 1.0691801834208634 20.320326850126527 -10.224591336087958 3.7667681089012057 0.9998185005410332 1.1532308304774865 0.5255875113574988 0.06862706618254252 48741949.10633084 71454673.88232712 100630.447172562 0.025114935783757657 5.962229155342942e-11 10.224591336087958 0.15341232993645337 QNSLTQFMSIPSSVIHPAMVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QNSLTQFMSIPSSVIHPAMVR 21 0 A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2;H7C2L8;A0A087WW69 A0A087WTA5 EIF2B4 Translation initiation factor eIF-2B subunit delta 0 17314500.0 4316700.0 6143900.0 6853900.0 False True 4179668.7213421147 8597191.310015246 5058657.977407404 1.0 2.0569073491677687 1.2103011780759125 21.994957168803346 -10.177956766378115 4.554470261674529 0.9998893454860234 1.633604263629553 0.42752898364198544 0.3456255220817742 0.0004010213029367128 7.238123096883019e-05 0.334710316968263 0.11155015758192506 6.638091487116944e-11 10.177956766378115 0.6337149181435295 QNSLTQFMSIPSSVIHPAMVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QNSLTQFMSIPSSVIHPAMVR 21 0 A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2;H7C2L8;A0A087WW69 A0A087WTA5 EIF2B4 Translation initiation factor eIF-2B subunit delta 0 16239470.0 998670.0 6592600.0 8648200.0 False True 1367905.287041979 6301317.133187159 6605673.27526986 1.0 4.606544906930958 4.829042871494613 20.38353691164942 -10.075177116227659 0.626051639845968 1.6947657046533206e-21 4.80026556435974 0.9996680419642754 0.03197445591059649 1.3499660351002534 0.30205526363532187 2.59971989895366 0.037336931676004055 8.410520694769365e-11 10.075177116227659 4.80026556435974 QNSLTQFMSIPSSVIHPAMVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QNSLTQFMSIPSSVIHPAMVR 21 0 A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2;H7C2L8;A0A087WW69 A0A087WTA5 EIF2B4 Translation initiation factor eIF-2B subunit delta 0 12795800.0 4316700.0 3277200.0 5201900.0 False True 3589527.312234493 3259545.0731267356 6289593.239131925 1.0 0.9080708376328408 1.7522065419852264 21.775362444237622 -6.8799129438007105 1.0802398770250408 0.9430836061109525 1.8119408350259825 0.9736170762959618 0.0614187421114414 0.12770929415575666 0.2727276502556369 0.043799959723867445 0.10590008266420788 1.3185210152838546e-07 6.8799129438007105 0.8688572289150299 QNVDVEAEDK(ub)DGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QNVDVEAEDKDGDR 14 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 28048000.0 8795700.0 11621000.0 7631300.0 True False 11531247.877679974 9887192.098303203 6841686.280598595 1.0 0.8574260308323589 0.593317076622856 23.45904530985734 -6.96151603175618 0.4135183312437818 1.0125215344712626 0.42836391682113195 0.999822346957533 0.002245614397149509 0.07916400855255944 0.019163072812038814 0.003404942959595597 0.022026656713812095 1.0926572915656389e-07 6.96151603175618 -0.5841576176501306 QNVDVEAEDK(ub)DGDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QNVDVEAEDKDGDR 14 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 32257500.0 6503500.0 10893000.0 14861000.0 True False 6297049.952335915 15242631.706244584 10968458.279556377 1.0 2.420598823515807 1.7418407607656956 22.58624468112537 -10.089442407966379 4.883519700574745 0.9999613467249294 2.081219792148747 0.7718598416639875 0.27710181878390355 0.00011662147528265299 2.174395371394679e-05 0.2683122214907466 0.08943422744221875 8.138747820119404e-11 10.089442407966379 1.0812584454238174 QNVDVEAEDK(ub)DGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QNVDVEAEDKDGDR 14 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 29410900.0 8795700.0 8559200.0 12056000.0 True False 12047707.984854994 8181026.242510628 9208621.101113927 1.0 0.6790525013384191 0.7643463065912584 23.522255371380233 -9.931876136964345 6.483752438156447 1.00000003304178 0.7216994039648298 0.9341883994748187 0.03482105018166314 1.6642260693582246e-08 2.711997847704033e-09 0.03371534088191685 0.011238445620914516 1.1698329858728089e-10 9.931876136964345 -0.2783006290769502 QNVDVEAEDK(ub)DGDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QNVDVEAEDKDGDR 14 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 28399600.0 6503500.0 15513000.0 6383100.0 True False 5407948.403900438 15429428.389910592 7717776.697880185 1.0 2.8531019968278994 1.4271172950381337 22.366649956559645 -6.57984820009956 2.2668776272444178 2.2619698239528825 1.4305641939611675 0.0 0.8050575330347886 0.6997459064905521 6.762792199938047 0.2981853538097515 0.9002414705457046 2.6311875159135347e-07 6.57984820009956 -0.831405629991715 QPAENVNQYLTDPK(ub)FVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 QPAENVNQYLTDPKFVER 18 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 30180900.0 11006000.0 12148000.0 7026900.0 True False 14428972.582255613 10335565.75253313 6299823.794784409 1.0 0.7163064240099498 0.43660931219259325 23.78246524032232 -6.9713004484611565 0.22498291895619926 1.121136677225839 0.023835055744740756 0.9999908224665469 0.0006967640913394749 0.0758830463733476 0.007502997424007013 0.007460079370615281 0.02805740091490926 1.068315554111744e-07 6.9713004484611565 -1.0973016214810984 down QPAENVNQYLTDPK(ub)FVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 QPAENVNQYLTDPKFVER 18 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 38250500.0 15164000.0 13427000.0 9659500.0 True False 14682627.120353939 18788471.12088002 7129387.171211535 1.0 1.27963960174636 0.4855661805460108 23.807606792774635 -6.811544159385595 1.4081422890245958 1.1521219097954496 0.47119057506963546 0.863804211501549 0.12136814291343527 0.2046959174993024 0.7996831483872718 0.06776824009836885 0.15664697786660792 1.5433194894737364e-07 6.811544159385595 -0.6809313347258141 down QPAENVNQYLTDPK(ub)FVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 QPAENVNQYLTDPKFVER 18 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 81626000.0 34469000.0 47157000.0 0.0 True False 52291993.02144347 38741464.91067733 0.0 1.0 0.7408680119495645 0.0 25.64008672134137 -7.35066382569833 0.7877889238106958 0.9894614589320271 8.627142569856888e-23 0.9878167100627152 0.04677204792136891 0.10894652260588752 0.1379171251624791 0.04017228251787759 0.07152788376680903 4.460013510505951e-08 7.35066382569833 -0.9894614589320271 down QPAENVNQYLTDPK(ub)FVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QPAENVNQYLTDPKFVER 18 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 33757000.0 11006000.0 10677000.0 12074000.0 True False 15075215.625966547 10205254.835882556 9222369.871835575 1.0 0.676955812048509 0.6117570786815384 23.845675301845212 -13.999999999999998 0.22497249508056413 2.9929736828368143 0.578501449832402 0.9995033548658147 0.003783004978576065 13.13971526203673 0.15021981459599426 11.665023409568224 0.03493512734743932 1.0000000000000041e-14 13.999999999999998 -2.414472233004412 QPAENVNQYLTDPK(ub)FVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QPAENVNQYLTDPKFVER 18 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 43687400.0 15164000.0 20851000.0 7672400.0 True False 12609537.879102988 20738671.524400547 9276663.36683053 1.0 1.6446813295806402 0.7356862286130385 23.58801206820891 -6.716207785761141 1.7728860468702814 1.393799889080207 0.7373923995666736 0.4945570365785532 0.27141885130626664 0.36276009387802705 2.2261797579869405 0.12165617455208345 0.30678175248396666 1.9221718565206395e-07 6.716207785761141 -0.6564074895135334 QPAENVNQYLTDPK(ub)FVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QPAENVNQYLTDPKFVER 18 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 148998000.0 34469000.0 55359000.0 59170000.0 True False 44620799.985568896 52278222.985527985 48401667.13546966 1.0 1.1716110648494789 1.0847332892087 25.41121304343382 -10.300303074253092 5.6661707448391505 0.9999860943467638 1.1281721770290907 0.7437261949602096 0.035467703384655797 6.231078888878782e-06 7.694510826257561e-07 0.034345180789897324 0.011447152044748991 5.008375999934603e-11 10.300303074253092 0.1281860826823269 QPDSPTALYHFNASLYLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QPDSPTALYHFNASLYLLR 19 0 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 0 34894000.0 11397000.0 0.0 23497000.0 False True 17290082.232307028 0.0 18852807.650899068 1.0 0.0 1.0903827638061803 24.043441394722063 -10.434518097056486 4.338530261558846 1.001601283900368 0.5451913819015762 0.1882941501510771 0.44514689928024087 640246969.7304902 21353.048197035492 10241714.015119148 0.15238543302419547 3.676900714091149e-11 10.434518097056486 -0.45640990199879183 QPDSPTALYHFNASLYLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QPDSPTALYHFNASLYLLR 19 0 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 0 31566300.0 11397000.0 7851300.0 12318000.0 False True 14753641.16845654 7414368.253152628 10076250.393353317 1.0 0.5025449764228126 0.6829670234149696 23.814567716814512 -10.198920349869784 4.970278481478226 1.000042487883134 0.5927559999183272 0.8716815918706128 0.0736569922484958 3.468225910498818e-05 5.589872008627324e-06 0.07132549886380021 0.023772692025566356 6.325278471067841e-11 10.198920349869784 -0.4072864879648068 QPGITFIAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QPGITFIAAK 10 0 A0A1B0GW44;A0A1B0GVD5;A0A1B0GWE8;A0A1B0GU92;A0A1B0GU03;P07339;C9JH19;A0A1B0GVP3;A0A1B0GV23;F8WD96;F8W787 A0A1B0GW44 CTSD Cathepsin D;Cathepsin D light chain;Cathepsin D heavy chain 0 7904700.0 1526900.0 3779400.0 2598400.0 False True 2001780.6865206347 3215528.251985812 2329542.493612803 1.0 1.6063339373979248 1.1637351230827702 20.932852491649506 -10.321003708491391 8.893677007404808 0.999999648020675 1.3850345302403475 0.5022551378142148 0.18069020930549462 1.2616960232172964e-06 9.61465412127123e-08 0.17495270449048872 0.058317514288576115 4.7752519599676466e-11 10.321003708491391 0.3850348822196725 QPGITFIAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QPGITFIAAK 10 0 A0A1B0GW44;A0A1B0GVD5;A0A1B0GWE8;A0A1B0GU92;A0A1B0GU03;P07339;C9JH19;A0A1B0GVP3;A0A1B0GV23;F8WD96;F8W787 A0A1B0GW44 CTSD Cathepsin D;Cathepsin D light chain;Cathepsin D heavy chain 0 6212700.0 1526900.0 2407400.0 2278400.0 False True 2091436.1929209824 2301033.1077927914 1740288.8451209352 1.0 1.100216738899922 0.8321022898099412 20.996062553172397 -6.805444047921202 1.4333450597312978 1.0549179462364349 0.8278735403981105 0.847676070344373 0.04317106308935091 0.2130695531895845 0.8635248140000642 0.023687460768233165 0.0549219996430079 1.5651499514262233e-07 6.805444047921202 -0.22704440583832441 QPLALNVAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QPLALNVAYR 10 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 48545000.0 13665000.0 16014000.0 18866000.0 False True 17914947.332048237 13624773.622083096 16913927.295450695 1.0 0.7605254634329622 0.944123752191735 24.09466046640353 -10.548666148560207 5.218107619504341 1.0006519278342505 0.8523246078123478 0.46312081930826066 0.07495368751786272 0.0005709445816983614 4.938318152098326e-05 0.07288955241120619 0.024191198624459318 2.827052355330119e-11 10.548666148560207 -0.14832732002190274 QPLALNVAYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QPLALNVAYR 10 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 19764300.0 7876600.0 2761700.0 9126000.0 False True 7626561.644432854 3864461.2120752465 6735626.825868475 1.0 0.5067108078640103 0.883180014782319 22.862601348985294 -9.793224077047896 6.20321261126752 1.0000000099652897 0.6949454113229038 0.4667966962085598 0.15369291013762243 2.117120264573754e-08 4.289672999671144e-09 0.14881252478283405 0.0496041734492928 1.6098148264906447e-10 9.793224077047896 -0.30505459864238593 QPLALNVAYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QPLALNVAYR 10 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 58062000.0 12357000.0 28570000.0 17135000.0 False True 18746472.417708 23471460.281571157 13748259.739462713 1.0 1.2520467722449966 0.733378495597713 24.160115808925298 -6.774538608770611 1.5568181283348848 1.143725782765353 0.7299281889232221 0.7477130424837084 0.10636986488642572 0.25914940624830196 1.240093815154251 0.05383342976476436 0.12763376584011527 1.6805885147827255e-07 6.774538608770611 -0.413797593842131 QPLALNVAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QPLALNVAYR 10 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 41002500.0 13665000.0 9712500.0 17625000.0 False True 18717319.78273967 9283369.635057526 13462337.998269161 1.0 0.49597750868253376 0.7192449642647858 24.15787052792642 -10.31856179119117 5.777811188943817 1.0000453414343822 0.6076112364736587 0.8046237267208821 0.0911485570576773 5.324262570469434e-05 6.279627827874803e-06 0.08826437630608125 0.029418070292934126 4.802177502491173e-11 10.31856179119117 -0.3924341049607235 QPLALNVAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QPLALNVAYR 10 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 17851200.0 7876600.0 4955400.0 5019200.0 False True 6549741.892544352 4928704.276630118 6068691.513841274 1.0 0.7525035883078872 0.9265542999105563 22.64300662441957 -9.973947783018819 5.368261932850435 1.0000004980577346 0.8395289443180649 0.5312631224364972 0.07105590546746673 4.2358849831806553e-07 8.097310488098868e-08 0.06879979889395646 0.02293319487685921 1.0618232168218011e-10 9.973947783018819 -0.1604715537396697 QPLALNVAYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QPLALNVAYR 10 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 46105000.0 12357000.0 16512000.0 17236000.0 False True 15996380.092885632 15593092.684785478 14099224.856294677 1.0 0.974788833113592 0.8814009653699894 23.931242131017747 -6.946641359410965 0.5945764007397113 1.0010657008614459 0.8503878760034022 0.9989106342183415 0.0016837626370271581 0.08486313774798938 0.041764997962308745 0.001737489817609669 0.007834522446418617 1.1307292860109248e-07 6.946641359410965 -0.1506778248580437 QPLCQLWAEK(ub)HGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QPLCQLWAEKHGAR 14 1 Q96BD0;E1P5H9;Q96BD0-3;Q96BD0-4;Q96BD0-2 Q96BD0 SLCO4A1 Solute carrier organic anion transporter family member 4A1 1 8544300.0 1536700.0 1746300.0 5261300.0 True False 2014628.5814239667 1485758.8470240857 4716911.145953293 1.0 0.737485242055849 2.34133040176533 20.942082456152356 -6.864898069207745 1.160665332234157 0.8552379473721153 2.426614048244024 0.959324949735608 0.14166216264134204 0.1418449487998082 0.360349120190753 0.0949832564632371 0.22310193252526384 1.3649034477375886e-07 6.864898069207745 1.571376100871909 up QPLWNHLLNYYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QPLWNHLLNYYK 12 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 25330500.0 5129600.0 8397900.0 11803000.0 False True 6724955.27511707 7144966.054757809 10581738.782370657 1.0 1.062455549882215 1.5735032203892905 22.681093242260147 -6.929677313171716 0.7494290907293585 0.9921352310373287 1.677564268668485 0.9964746479819079 0.015253325554136764 0.09280527412465214 0.0785012931491931 0.013870052632675099 0.04632312969077654 1.1757708445239947e-07 6.929677313171716 0.6854290376311564 QPLWNHLLNYYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QPLWNHLLNYYK 12 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 15267600.0 6456100.0 3293400.0 5518100.0 False True 6251154.639390473 4608471.794854111 4072744.07054841 1.0 0.7372192915873004 0.6515186882251769 22.575691261286167 -13.999999999999998 0.15667002287189646 2.2854699570875616 0.5640968175542957 0.9995455248189008 0.0031607302657456035 11.989152870711422 0.12496282108510817 4.684970850934508 0.07935764426959589 1.0000000000000041e-14 13.999999999999998 -1.7213731395332659 QPLWNHLLNYYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QPLWNHLLNYYK 12 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 30967100.0 5129600.0 9517500.0 16320000.0 False True 7026151.7422277015 9096985.379836291 12465552.1209505 1.0 1.2947322679017481 1.7741649452333332 22.744303303783038 -6.963875274719048 0.3768626417447067 0.965883573531019 2.11988336828015 0.9998880419881581 0.003375718902926169 0.07834479275395788 0.016218971631543563 0.006261013525146022 0.04057368558100775 1.0867376796216684e-07 6.963875274719048 1.1539997947491312 QPLWNHLLNYYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QPLWNHLLNYYK 12 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 13130400.0 6456100.0 1366200.0 5308100.0 False True 5368533.203724404 1358840.0094305312 6417999.168118606 1.0 0.2531119689243684 1.1954846742246352 22.356096536720443 -6.695512000047184 1.847009886229754 0.5341785617081717 1.1924432864255459 0.3962223779714684 0.31553831176104963 0.4049467058478017 2.682511423061262 0.13646038174754266 0.3528797395150013 2.0159882658613998e-07 6.695512000047184 0.6582647247173742 QPLWNHLLNYYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QPLWNHLLNYYK 12 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 24195500.0 4053300.0 11243000.0 8899200.0 False True 5247076.752487923 10617317.166608712 7279636.913502982 1.0 2.0234728149487173 1.3873700075096695 22.32308246272091 -10.145731306704345 4.896259395462309 0.9999536858665248 1.7054214112317863 0.621178277959541 0.25968788370523654 181583687.5506645 10.500858583825769 94816.81580761557 0.08889806988372666 7.149385139939133e-11 10.145731306704345 0.7054677253652615 QPPSQFEPLDMK(ub)LMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 QPPSQFEPLDMKLMR 15 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 50266600.0 10445900.0 11678300.0 28142400.0 True False 13694676.05823948 9935943.161656866 25230494.40896279 1.0 0.7255332743470663 1.8423578843095538 23.707111804318437 -6.841701152090666 1.2743703247556688 0.8539999122364871 1.880367620487866 0.9273495209104557 0.1280798416754523 0.1668263965068304 0.5255300862944629 0.07878259563331881 0.18160138020556704 1.4397889890004103e-07 6.841701152090666 1.026367708251379 QPPSQFEPLDMK(ub)LMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QPPSQFEPLDMKLMR 15 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 62416100.0 7843700.0 8831400.0 45741000.0 True False 7594706.036924312 12357824.075142581 33760059.89941375 1.0 1.6271629231020541 4.445209562460673 22.856562693725127 -6.942213631517075 0.6386368461176902 0.9691770680777124 5.257337391963673 0.9984397174857713 0.05918355881232764 0.08677110322646521 0.05011847345392151 0.05862741760624302 0.2402777454754468 1.1423162857607165e-07 6.942213631517075 4.28816032388596 QPPSQFEPLDMK(ub)LMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QPPSQFEPLDMKLMR 15 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 235663000.0 19583000.0 24760000.0 191320000.0 True False 29708842.709069822 20341384.549237024 153505518.1414651 1.0 0.6846912465905983 5.166997571891326 24.824389071121487 -6.890021807210327 1.0222890851169584 0.7592850946662193 5.552631435595702 0.9809109792151195 0.2822284195380451 0.11912403522209827 0.2217617519455909 0.21035486274390944 0.5244417042980698 1.2881848664972814e-07 6.890021807210327 4.7933463409294825 up QPPSQFEPLDMK(ub)LMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QPPSQFEPLDMKLMR 15 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 58845400.0 10445900.0 16961600.0 31437900.0 True False 14308031.519833159 16212180.427489484 24012915.50387436 1.0 1.1330825211711952 1.6782822620001028 23.77032186584133 -6.944326764099289 0.6180082723003999 0.9940239448737856 1.8461256426444794 0.9986773889625292 0.01067213621866907 0.08584715048623613 0.04603045309625735 0.010767283101987508 0.04610593451812415 1.1367716545443326e-07 6.944326764099289 0.8521016977706938 QPPSQFEPLDMK(ub)LMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 QPPSQFEPLDMKLMR 15 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 82193700.0 10860400.0 20397700.0 50935600.0 True False 9030903.797296897 20287813.541473553 61585998.460394874 1.0 2.2464876159511347 6.8194723189088355 23.106438946690307 -6.946862857406544 0.592284868126082 0.9474904864862708 8.349480581551587 0.9989315330017251 0.0817782050644315 0.0847704650960501 0.04136824228802329 0.08458407786531275 0.38336711212265345 1.1301527407781531e-07 6.946862857406544 7.401990095065316 QPPSQFEPLDMK(ub)LMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QPPSQFEPLDMKLMR 15 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 196204000.0 19583000.0 26251000.0 150370000.0 True False 25350579.5386404 24790108.773516424 123004202.92649287 1.0 0.9778912050405127 4.852125875031961 24.595515393213937 -6.905615596398537 0.925085867731025 0.8627879688784206 5.308534362752241 0.9891589168856603 0.18961836107943061 0.10738889273450873 0.15502650935221968 0.15195336876546353 0.4077443348222323 1.2427518078933908e-07 6.905615596398537 4.44574639387382 up QPQPSPAEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QPQPSPAEGR 10 0 P56192;P56192-2;H0YHV5 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 1539530.0 561430.0 341840.0 636260.0 False True 543607.7119612446 478338.49467205076 469604.41860914644 1.0 0.8799332388907554 0.8638663659036279 19.052206397667433 -13.999999999999897 0.2834556683819858 1.9974165754687598 0.8591920427971799 0.9996128398055498 0.001195173152134873 15.588162894218637 0.16870896718560552 9.031629667334157 0.0062530740265449155 1.0000000000002373e-14 13.999999999999897 -1.1382245326715799 QPQQRPWWTGWFGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QPQQRPWWTGWFGK 14 1 Q15637-6;Q15637-2 Q15637-6 SF1 Splicing factor 1 0 9021500.0 1875000.0 3444200.0 3702300.0 False True 2568238.16996977 3292023.855553685 2827892.9912619493 1.0 1.2818218707466817 1.1011023137683666 21.292347568786457 -10.227107439652292 3.560372194396752 0.9996620931907438 1.191462092411733 0.59944877359189 0.07377845111424915 52413582.701500304 78312819.25880772 192847.4257004079 0.02700015375058253 5.927786595538081e-11 10.227107439652292 0.19179999922098911 QPSLHMSAAAASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QPSLHMSAAAASR 13 0 O94776;O94776-2;E9PCS8;F6RRE2;E7EV10;E7ESY4;Q13330-2;Q9BTC8;Q13330-3;Q13330;H0Y4T7;E7EQY4;Q9BTC8-2 O94776;E7EQY4 MTA2;MTA3;MTA1 Metastasis-associated protein MTA2;Metastasis-associated protein MTA1;Metastasis-associated protein MTA3 0 8459500.0 3788400.0 1946700.0 2724400.0 False True 4966629.086917785 1656259.948177167 2442505.2222901452 1.0 0.3334776805740927 0.49178329598313675 22.243835578139738 -10.33271520082302 8.685050612237346 1.000000940825652 0.41263048828119003 0.9483354001527194 0.064627996861572 1.1773097695851065e-06 9.050718388875721e-08 0.06257588863605201 0.02085859629530113 4.648199923224115e-11 10.33271520082302 -0.5873704525444621 QPSLHMSAAAASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QPSLHMSAAAASR 13 0 O94776;O94776-2;E9PCS8;F6RRE2;E7EV10;E7ESY4;Q13330-2;Q9BTC8;Q13330-3;Q13330;H0Y4T7;E7EQY4;Q9BTC8-2 O94776;E7EQY4 MTA2;MTA3;MTA1 Metastasis-associated protein MTA2;Metastasis-associated protein MTA1;Metastasis-associated protein MTA3 0 9827900.0 2906600.0 3069500.0 3851800.0 False True 3762650.99765164 2898679.6266926434 3150811.922805516 1.0 0.770382272632189 0.8373914893440856 21.843318048656194 -9.965497063537825 6.345990006062838 1.0000000534024707 0.8038868809881298 0.9194875700117211 0.027356398167981244 2.0654764891123096e-08 3.3897059452193223e-09 0.0264877259310845 0.008829239543063572 1.082687035641172e-10 9.965497063537825 -0.1961131724143409 QPVVASVSLLIFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QPVVASVSLLIFK 13 0 Q9BV79-2;Q9BV79 Q9BV79-2 MECR Trans-2-enoyl-CoA reductase, mitochondrial 0 17811800.0 4387700.0 7411800.0 6012300.0 False True 6656461.683837292 6089106.381342291 4823966.269715297 1.0 0.9147662332568354 0.7247042796668508 22.666324069792832 -6.9578628095717745 0.4645800115775001 1.0052937240998427 0.6264559631280519 0.9996825175038211 0.0020503663037745776 0.08047366456433301 0.02402094564307699 0.002601942054565139 0.015693787421120896 1.1018873326624652e-07 6.9578628095717745 -0.3788377609717909 QPVVASVSLLIFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QPVVASVSLLIFK 13 0 Q9BV79-2;Q9BV79 Q9BV79-2 MECR Trans-2-enoyl-CoA reductase, mitochondrial 0 15282500.0 4387700.0 5717700.0 5177100.0 False True 5679964.1444973955 5399504.968737753 4234920.921531862 1.0 0.950623072853137 0.7455893758826885 22.43745039188528 -6.9440163731230085 0.6210770687340562 1.0022424516104862 0.6830876234077821 0.9986440312319309 0.004056185201811993 0.08598122814073765 0.04661828639230042 0.0040808814605696655 0.017359134166121212 1.1375843975042037e-07 6.9440163731230085 -0.31915482820270413 QPYFGAVIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QPYFGAVIGR 10 0 Q96C23;H7C320 Q96C23 GALM Aldose 1-epimerase 0 17483500.0 6314100.0 5537000.0 5632400.0 False True 8277846.24583138 4710901.183056959 5049613.27779585 1.0 0.5690974491618892 0.6100153503501919 22.98082402127041 -9.92266847923555 7.009985721227189 1.0000000115126721 0.5895564003370858 0.9926012922461296 0.016704663209499444 3.0118732578401825e-09 4.813426973231751e-10 0.016174220844610374 0.005391406867865427 1.1948998889426647e-10 9.92266847923555 -0.41044361117558636 QPYFGAVIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QPYFGAVIGR 10 0 Q96C23;H7C320 Q96C23 GALM Aldose 1-epimerase 0 5958400.0 4498300.0 1460100.0 0.0 False True 4355503.928744927 2043125.5443209107 0.0 1.0 0.4690905065742079 0.0 22.054408216608028 -8.028071656928027 0.5745067407029373 1.0158881198689818 1.8780957607301597e-15 0.9898020343163563 0.04125319440258421 0.11229220968795307 0.1659377474914707 0.046982991485464615 0.07582170711571402 9.374073255428513e-09 8.028071656928027 -1.01588811986898 QPYFGAVIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QPYFGAVIGR 10 0 Q96C23;H7C320 Q96C23 GALM Aldose 1-epimerase 0 15957300.0 6314100.0 3803100.0 5840100.0 False True 8648593.402136596 3635066.4668300943 4460788.660634996 1.0 0.4203072450986154 0.5157819836382849 23.044034082793303 -10.827970714522676 7.3906242791272305 1.028475502440547 0.46804461436845846 0.9764104197371388 0.038977398791304366 0.015603697384270965 0.0003632019865860494 0.03220021489626192 0.012579901366433903 1.4860358457286957e-11 10.827970714522676 -0.5604308880720885 QPYFGAVIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QPYFGAVIGR 10 0 Q96C23;H7C320 Q96C23 GALM Aldose 1-epimerase 0 10754500.0 4498300.0 3971500.0 2284700.0 False True 3740535.7584785633 3950104.741218975 2762420.2067407495 1.0 1.0560264615210235 0.738509236405307 21.834813492042304 -6.861321395887834 1.1789285364931283 1.0305142513614314 0.722732671125945 0.9552334356288114 0.029277943274217767 0.14545302777789437 0.3833791824460349 0.019357862978087014 0.04525978157122628 1.3761906539267718e-07 6.861321395887834 -0.3077815802354864 QPYTLVVFFNKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QPYTLVVFFNKR 12 1 Q8WV28-2;Q8WV28 Q8WV28-2 BLNK B-cell linker protein 0 13401300.0 1707200.0 3284900.0 8409200.0 False True 2589947.213038042 2698683.9299591575 6747117.934116702 1.0 1.0419841440681588 2.6051179345088826 21.304491263272947 -6.912657397636942 0.8774289322591544 0.9555742444220185 2.8190545236394877 0.9918866447315099 0.06728186749155125 0.1026872748840647 0.12942436317303432 0.05581874346594987 0.15707822005214464 1.2227638828731432e-07 6.912657397636942 1.8634802792174692 up QPYTLVVFFNKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QPYTLVVFFNKR 12 1 Q8WV28-2;Q8WV28 Q8WV28-2 BLNK B-cell linker protein 0 12780500.0 1707200.0 5299600.0 5773700.0 False True 2210004.053943056 5004672.601277193 4722945.843164797 1.0 2.264553584120324 2.137075646869601 21.075617585365396 -10.326698036610809 6.29088306277751 0.9999302143583175 2.2008146154949326 0.9916184566653751 0.05204264995446856 5.0945939970052045e-05 5.452568662309947e-06 0.050392955621920636 0.01679669304717971 4.7130490910615195e-11 10.326698036610809 1.200884401136615 QQAK(ub)FDECVLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQAKFDECVLDK 12 1 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 373203200.0 105598200.0 125114000.0 142491000.0 True False 138440262.81442335 106447478.89055236 127747398.19018683 1.0 0.7689054956016896 0.9227618872800746 27.044688344523806 -10.09091365700071 4.564773615142091 1.0000109198360299 0.8458336915467964 0.5724139006845832 0.06281160889760293 87365947.27007756 3.335918055760787 10027.497840206424 0.021502084413822346 8.111223027554313e-11 10.09091365700071 -0.15417722828923341 QQAK(ub)FDECVLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQAKFDECVLDK 12 1 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 264546100.0 163324000.0 59984600.0 41237500.0 True False 158139369.01903751 83936763.59555668 30436161.65151779 1.0 0.5307771500305658 0.19246416525067678 27.23662133247536 -8.122270563572075 0.30566914516441973 1.130788523507476 1.49058985302007e-22 0.9990006881100272 0.010467200611118076 0.09091094115555721 0.06569203403033282 0.06986284255250255 0.09247350551199335 7.546219549980591e-09 8.122270563572075 -1.130788523507476 down QQAK(ub)FDECVLDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQAKFDECVLDK 12 1 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 781819000.0 251890000.0 235179000.0 294750000.0 True False 382135545.6256752 193209469.9880862 236492533.3064856 1.0 0.505604548437759 0.6188708064811753 28.509509220177605 -9.847761022470403 6.516567430010763 1.0000000135704852 0.5622376774594645 0.9521909969648109 0.04624075621362605 9.078163527450911e-09 1.6380675011060194e-09 0.04477242101710095 0.014924139894260249 1.4198385958128667e-10 9.847761022470403 -0.43776233611102067 QQAK(ub)FDECVLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QQAKFDECVLDK 12 1 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 303446600.0 105598200.0 103926500.0 93921900.0 True False 144640708.22405407 99334683.59102249 71739481.60224883 1.0 0.6867685094375313 0.49598403162629423 27.107898406046697 -9.420557250756936 0.10893591153463693 1.6725876887170157 1.7361948987673728e-09 0.9999338988540323 0.0016892784534476262 0.8745706219830371 0.0416915201887108 0.40044113595764014 0.22718173201877243 3.797018815703842e-10 9.420557250756936 -1.6725876869808207 QQAK(ub)FDECVLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQAKFDECVLDK 12 1 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 261852700.0 163324000.0 43254200.0 55274500.0 True False 135811142.47999305 43021181.03931351 66832142.38958791 1.0 0.3167721017121342 0.4920961650803671 27.017026607909635 -10.688888297800966 10.20203632564212 1.0003989853156496 0.40443413339894574 0.9389709144836821 0.07157574914725906 0.0006499269211598381 1.9819504487977243e-05 0.0693432536994387 0.023100973703304502 2.0469710577951325e-11 10.688888297800966 -0.5959648519167039 QQAK(ub)FDECVLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QQAKFDECVLDK 12 1 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 716344000.0 251890000.0 235581000.0 228873000.0 True False 326076570.4942108 222470710.25765765 187220462.43529418 1.0 0.6822652419352755 0.5741610387754558 28.280635542270055 -13.999999999999998 0.1505053703001792 2.537587557900869 0.45591324787894627 0.9995645609486941 0.003771389137825867 11.959668367456471 0.12220630202925103 5.37707045365517 0.1066343341582996 1.0000000000000041e-14 13.999999999999998 -2.0816743100219224 QQALTVSTDPEHRFELALQLGELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QQALTVSTDPEHRFELALQLGELK 24 1 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 0 25245900.0 8916300.0 7331200.0 8998400.0 False True 11542326.116549008 6923212.275357268 7360783.531380951 1.0 0.5998108358271903 0.6377209807672392 23.460430662773213 -9.78841410028367 6.375145375103522 1.0000000071969957 0.6187659088010086 0.9926382719739264 0.01547675186362981 1.585470112982568e-09 2.9772439643890985e-10 0.01498530088998027 0.004995100185010957 1.6277432374285497e-10 9.78841410028367 -0.3812340983959871 QQANTIFWSPQGQFVVLAGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQANTIFWSPQGQFVVLAGLR 21 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 261015000.0 79373000.0 84504000.0 97138000.0 False True 120414643.94357328 69423600.96723449 77938631.72290216 1.0 0.5765378586325981 0.6472521046478739 26.84343561182841 -10.702512500473873 6.789158432046859 1.0037090227026255 0.6118949816402499 0.975706188698913 0.028868970047177367 0.0016307263528577472 7.145516553043432e-05 0.028124799428468347 0.009317420017906558 1.9837525568618877e-11 10.702512500473873 -0.3918140410623756 QQANTIFWSPQGQFVVLAGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QQANTIFWSPQGQFVVLAGLR 21 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 191973000.0 79373000.0 51126000.0 61474000.0 False True 102749913.17573923 48280793.15663404 50286362.77650612 1.0 0.46988646184115557 0.4894054040756063 26.61456193392086 -10.443519447475085 9.39733932181942 1.0000030680495635 0.47964593297474534 0.9989458119889844 0.007968574798877403 5.122119246487896e-07 3.032935203877664e-08 0.007715584751630517 0.0025718464574216947 3.601476228153256e-11 10.443519447475085 -0.5203571350748182 QQASHYLYVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQASHYLYVR 10 0 Q9Y3A4 Q9Y3A4 RRP7A Ribosomal RNA-processing protein 7 homolog A 0 4761000.0 1496800.0 1445000.0 1819200.0 False True 1962319.2950318197 1229411.6325658844 1630966.634998619 1.0 0.6265094756385958 0.8311423319986121 20.90412837534638 -10.095828331887756 5.111044130431776 1.000006486148747 0.7288259038179864 0.7007284919659658 0.08354101378386326 6.174486372885367e-06 1.0924087871552068e-06 0.0808901728793999 0.026962746258873665 8.019950136802623e-11 10.095828331887756 -0.2711805823307606 QQEEEK(ub)AEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QQEEEKAEAR 10 1 O43818 O43818 RRP9 U3 small nucleolar RNA-interacting protein 2 1 3974600.0 1478900.0 1589300.0 906400.0 True False 2025689.2957697548 1519079.4708877166 692326.9878939668 1.0 0.7499074384507086 0.34177353325594045 20.94998147701345 -6.963818495361526 0.37778199151949327 1.0287434615696358 0.048555526299944425 0.9998866790726049 0.0028879328154186893 0.07836422847995834 0.016287907890912577 0.005324234433565414 0.03452409943339623 1.0868797682356798e-07 6.963818495361526 -0.9801879352696914 down QQEEEK(ub)AEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQEEEKAEAR 10 1 O43818 O43818 RRP9 U3 small nucleolar RNA-interacting protein 2 1 3405510.0 1356000.0 1705700.0 343810.0 True False 1127574.0809854693 1696511.0555450593 415699.081402169 1.0 1.5045672689304408 0.3686667584970198 20.10479079017461 -6.785958178484585 1.512403868319249 1.2835000604035642 0.35789334971660103 0.787940653630693 0.21398976222710664 0.24145105545245685 1.091081379309443 0.11139482158426584 0.26159536764067887 1.6369741505166534e-07 6.785958178484585 -0.9256067106869632 down QQEELASILSK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQEELASILSK 11 0 Q9Y264-2;Q9Y264 Q9Y264-2 ANGPT4 Angiopoietin-4 1 16087800.0 4700700.0 6953800.0 4433300.0 True False 6162663.221643561 5916320.145700097 3974584.6432164526 1.0 0.9600265230982775 0.6449459430555163 22.55512252192017 -6.930372983209305 0.7437249990613789 1.0047257735386796 0.5796430255771512 0.9966110088045623 0.00924414115713119 0.09244473547051332 0.07673508089954778 0.008440599053130366 0.028451142078496083 1.1738889560354516e-07 6.930372983209305 -0.42508274796152845 QQEELASILSK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQEELASILSK 11 0 Q9Y264-2;Q9Y264 Q9Y264-2 ANGPT4 Angiopoietin-4 1 9473300.0 4042700.0 2260900.0 3169700.0 True False 3914366.7013621 3163689.160437743 2339460.4810382756 1.0 0.8082250340359936 0.5976600200037986 21.900347484577452 -6.969924286070365 0.25998769447219705 1.0591251757606222 0.3405128278055324 0.999981785188573 0.0007012502025059969 0.07632727617200478 0.009117989504564975 0.004395944651680212 0.019867503582896098 1.0717061278038364e-07 6.969924286070365 -0.7186123479550898 QQEELASILSK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQEELASILSK 11 0 Q9Y264-2;Q9Y264 Q9Y264-2 ANGPT4 Angiopoietin-4 1 25041200.0 4458600.0 9109600.0 11473000.0 True False 6764022.16732158 7483920.706370334 9205356.521205457 1.0 1.1064305410657487 1.360929383951235 22.689449957137196 -6.956408012448678 0.4834077977225714 0.9940829735982825 1.4839489627398286 0.9996129000120297 0.0029792694486924587 0.08101014043051774 0.026069067572931863 0.0036135328357563383 0.020991904711807213 1.1055846175386357e-07 6.956408012448678 0.4898659891415461 QQEELASILSK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QQEELASILSK 11 0 Q9Y264-2;Q9Y264 Q9Y264-2 ANGPT4 Angiopoietin-4 1 18385400.0 4700700.0 4966900.0 8717800.0 True False 6438675.821641016 4747445.934658145 6658835.188726853 1.0 0.7373326544413864 1.0341932678681942 22.61833258344306 -6.673133228858993 1.9258847167428945 0.8328003577419497 1.0330221864295281 0.29320140393954397 0.11149430628024551 0.4539407112062474 3.248785137336222 0.046553408406167486 0.12389033446417064 2.12259321252782e-07 6.673133228858993 0.20022182868757843 QQEELASILSK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQEELASILSK 11 0 Q9Y264-2;Q9Y264 Q9Y264-2 ANGPT4 Angiopoietin-4 1 8407000.0 4042700.0 2414100.0 1950200.0 True False 3361684.171976369 2401094.764138665 2357977.803294 1.0 0.7142535233246009 0.701427523427259 21.68075276001173 QQEGESRLNLVQRNVNIFKFIIPNVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQEGESRLNLVQRNVNIFKFIIPNVVK 27 3 P00338;P00338-3;P00338-5;P00338-2;F5GXY2;F5GYU2 P00338 LDHA L-lactate dehydrogenase A chain 0 75222000.0 27920000.0 21375000.0 25927000.0 False True 23216717.06571854 21259848.632394683 31348215.827096485 1.0 0.9157129568412005 1.3502432638671724 24.468660648135284 -6.8563981467718 1.203743022916732 0.9546366641983521 1.3698885708942738 0.9491152975377332 0.042441358274896465 0.1505601995440413 0.4166068142719767 0.027536085768107867 0.06404119684666763 1.391880188279516e-07 6.8563981467718 0.4152519066959217 QQEK(ub)AHMMNAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQEKAHMMNAIK 12 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 7733000.0 1051000.0 1724100.0 4957900.0 True False 1017636.5802883146 2412542.121062722 3659277.2561881766 1.0 2.370730541525154 3.595858607157614 19.95679100556617 -6.972454396245618 0.19065374147559547 0.17673560099030136 5.823344995717442 0.9999957347177266 0.0021898047431059653 0.07551404926924526 0.006086927244125745 0.043012081243699096 0.13331147799964665 1.0654807402235888e-07 6.972454396245618 5.646609394727141 QQELDNLLHEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQELDNLLHEKR 12 1 Q12788;J3KNP2 Q12788 TBL3 Transducin beta-like protein 3 1 8468200.0 3451600.0 1391200.0 3625400.0 True False 4525081.025341945 1183638.3828551266 3250278.385292427 1.0 0.26157285940878444 0.7182807041663557 22.109512194406747 -10.78296600557092 7.787398381350481 1.0104112372741771 0.4899267817875701 0.6245023403098298 0.1864501968637138 0.033231886140639356 0.0009261676886320616 0.17800982206424362 0.06017654227918813 1.648291406594164e-11 10.78296600557092 -0.520484455486607 QQELDNLLHEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QQELDNLLHEKR 12 1 Q12788;J3KNP2 Q12788 TBL3 Transducin beta-like protein 3 1 9476500.0 3451600.0 1249200.0 4775700.0 True False 4727749.7959827455 1194006.213448017 3647778.01862888 1.0 0.2525527502454943 0.7715674847532039 22.17272225592964 -9.949858056514262 6.349019682455649 1.0000001049528933 0.5120601175023566 0.5409584982492586 0.21188687808841128 3.149321419035124e-07 5.200284302509562e-08 0.2051586333850649 0.0683861958430126 1.1223852313311222e-10 9.949858056514262 -0.4879399874505367 QQELDNLLHEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQELDNLLHEKR 12 1 Q12788;J3KNP2 Q12788 TBL3 Transducin beta-like protein 3 1 8925500.0 1586200.0 2547500.0 4791800.0 True False 1318995.5805745965 2533776.1118608434 5793743.2252200795 1.0 1.9209890837974224 4.392541802676958 20.331008300029026 -6.95392584556965 0.5139404581233238 0.9559471833913782 5.46674564821317 0.9994744465366227 0.032837884926591863 0.08194656907368687 0.029726779299576723 0.03757055632679938 0.20404174986720203 1.1119215682188984e-07 6.95392584556965 4.510798464821791 QQELIQK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQELIQKK 8 1 P46063;F8WA66;F8WD97;F5H2L2;F5H4P4;F5H3W0;F5GYB7 P46063 RECQL ATP-dependent DNA helicase Q1 1 112929000.0 30686000.0 44129000.0 38114000.0 True False 40229643.16364674 37545125.21349478 34170328.89530413 1.0 0.9332701525779923 0.849381853980299 25.261755605547677 -6.968026080920194 0.3016327224074663 1.0142696065717913 0.7657477116769361 0.9999626237594119 0.00037669149729158374 0.07694855735104934 0.011310581532269078 0.0013805856113962307 0.007510653931261424 1.076400570026226e-07 6.968026080920194 -0.2485218948948552 QQELIQK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQELIQKK 8 1 P46063;F8WA66;F8WD97;F5H2L2;F5H4P4;F5H3W0;F5GYB7 P46063 RECQL ATP-dependent DNA helicase Q1 1 80470000.0 23507000.0 31779000.0 25184000.0 True False 22760783.15208124 44468520.42529565 18587554.89619455 1.0 1.953734198343235 0.8166483012468273 24.4400468629011 -6.684158012804733 1.8865288561634366 1.6011300953045242 0.8207559530294852 0.3436059712034545 0.4038457471947051 0.42929933594405517 2.9572907195767835 0.17152561885441317 0.45008850375714865 2.06938828985463e-07 6.684158012804733 -0.780374142275039 QQELIQK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQELIQKK 8 1 P46063;F8WA66;F8WD97;F5H2L2;F5H4P4;F5H3W0;F5GYB7 P46063 RECQL ATP-dependent DNA helicase Q1 1 69955000.0 26168000.0 20646000.0 23141000.0 True False 39698769.1370545 16961559.99206572 18567171.206939396 1.0 0.4272565714445272 0.46770143282878135 25.242590941418662 -10.065374978910654 6.161131332805685 1.0000009638317437 0.4474790042257638 0.9959973407203673 0.016511545518212236 2.1859939569219648e-07 3.3175831256959595e-08 0.015987263072712463 0.0053290784010089475 8.602506730685303e-11 10.065374978910654 -0.5525219596059799 QQELIQK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QQELIQKK 8 1 P46063;F8WA66;F8WD97;F5H2L2;F5H4P4;F5H3W0;F5GYB7 P46063 RECQL ATP-dependent DNA helicase Q1 1 104969000.0 30686000.0 35029000.0 39254000.0 True False 42031443.45796927 33481302.95458743 29983013.661506817 1.0 0.7965775191153776 0.7133472275699815 25.32496566707057 -13.99999999995194 0.12288594435705479 1.9678521309954213 0.5855289297207081 0.999678904823791 0.0021575575694726006 11.953601149356505 0.10824675503431942 2.815181316106339 0.11346007862271235 1.0000000001106608e-14 13.99999999995194 -1.3823232012747133 QQELIQK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQELIQKK 8 1 P46063;F8WA66;F8WD97;F5H2L2;F5H4P4;F5H3W0;F5GYB7 P46063 RECQL ATP-dependent DNA helicase Q1 1 78821000.0 23507000.0 36382000.0 18932000.0 True False 19547112.036670655 36186002.94473839 22890593.668322243 1.0 1.8512199079256793 1.171047345785872 24.220452138335375 -10.254883862800998 4.808365156040469 0.9998664192177755 1.511133626856647 0.42953492826803585 0.27767928571700295 0.00039773972232999853 6.163506668672374e-05 0.26893147669852296 0.08962060409696702 5.56052934721188e-11 10.254883862800998 0.5112672076388716 QQELIQK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QQELIQKK 8 1 P46063;F8WA66;F8WD97;F5H2L2;F5H4P4;F5H3W0;F5GYB7 P46063 RECQL ATP-dependent DNA helicase Q1 1 48970100.0 26168000.0 14995000.0 7807100.0 True False 33874991.84839612 14160515.068335645 6386287.907610712 1.0 0.4180226856351584 0.1885251496499794 25.01371726351111 -10.634085210906058 0.19775392764859903 1.8458409230875863 1.3877477590010695e-24 0.9993967225177361 0.008388851592442632 2.4522138100645305 0.10373460645849122 1.1375772139260452 0.1419686266871572 2.3222811076487788e-11 10.634085210906058 -1.8458409230875863 QQELMDENFDLSK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QQELMDENFDLSKR 14 1 Q13137-5;Q13137-2;Q13137;Q13137-3;Q13137-4;D6REB0;H0Y9G3 Q13137-5 CALCOCO2 Calcium-binding and coiled-coil domain-containing protein 2 1 10891200.0 3272700.0 4279900.0 3338600.0 True False 4482705.631392028 4090799.866263339 2550091.440625332 1.0 0.9125738343414288 0.5688732766138481 22.095938333474184 -6.945272638887379 0.6085358896134386 1.0038099997504641 0.4597831779722729 0.9987761275406415 0.006509922275449656 0.08544139195464788 0.044259527064185615 0.006626390308466245 0.028966881797041984 1.1342985087299238e-07 6.945272638887379 -0.5440268217781912 QQELMDENFDLSK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQELMDENFDLSKR 14 1 Q13137-5;Q13137-2;Q13137;Q13137-3;Q13137-4;D6REB0;H0Y9G3 Q13137-5 CALCOCO2 Calcium-binding and coiled-coil domain-containing protein 2 1 17461300.0 5843300.0 8003600.0 3614400.0 True False 4858962.852081405 7960483.018209789 4370154.328902596 1.0 1.6383090919906507 0.8994006461750533 22.21221697207721 -6.678192961951099 1.9082162432139258 1.4045237784782727 0.9022491478577563 0.31584857439356007 0.2706392201305187 0.44258994391079043 3.1142534568026923 0.11386755320333157 0.3010251407853192 2.0980075080376265e-07 6.678192961951099 -0.5022746306205164 QQEQK(ub)YPQGVASQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQEQKYPQGVASQR 14 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 9678900.0 3658400.0 3494700.0 2525800.0 True False 4796197.827996 2973304.38223391 2264454.4451844296 1.0 0.6199294709818608 0.4721353301914548 22.193459735912562 -13.999999999994355 0.13066247772545142 2.8063713332511817 0.26689068871655314 0.9996426273458283 0.004203283259891563 11.935800059201364 0.1124747426641243 5.533917748254004 0.18257690434279292 1.0000000000129987e-14 13.999999999994355 -2.5394806445346285 QQEQK(ub)YPQGVASQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQEQKYPQGVASQR 14 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 17837000.0 6438300.0 6688300.0 4710400.0 True False 6233919.690647243 9358973.06902373 3476604.931029026 1.0 1.501298305633454 0.5576916456342838 22.57170813868411 -6.762400140756756 1.6036875333983172 1.2903150329951207 0.5538590696502607 0.7005968658888848 0.21092411829883984 0.2789018362279743 1.4142531916454186 0.10375313786413694 0.24872269704315703 1.7282233128248816e-07 6.762400140756756 -0.7364559633448601 QQEQK(ub)YPQGVASQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQEQKYPQGVASQR 14 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 29901700.0 6169400.0 7184300.0 16548000.0 True False 9359430.843554875 5902205.533807898 13277280.546753932 1.0 0.6306158603514118 1.418599140127947 23.15798937005733 -6.77922561823082 1.5387739418216009 0.790633756333461 1.4247019653701904 0.7646654095107916 0.15615878838069105 0.25178668697750417 1.1775157117500819 0.07993214634591195 0.18873771973540138 1.6625487233168708e-07 6.77922561823082 0.6340682090367294 QQEQK(ub)YPQGVASQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QQEQKYPQGVASQR 14 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 9370300.0 3658400.0 2978600.0 2733300.0 True False 5011009.344542618 2846995.6030869843 2087750.8340805185 1.0 0.5681481329081107 0.41663279601628417 22.256669797435453 -13.999999999999998 0.1459999837029096 3.076399084317604 0.24201855000008657 0.9995801340668488 0.005064357912020455 11.944952004856715 0.1201172512827794 7.045961040086867 0.1568171083747973 1.0000000000000041e-14 13.999999999999998 -2.8343805343175172 QQEQK(ub)YPQGVASQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQEQKYPQGVASQR 14 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 18001100.0 6438300.0 8246200.0 3316600.0 True False 5353731.715050698 8201776.08385746 4010085.7257742253 1.0 1.531973681236246 0.7490262753549747 22.352113414118385 -6.723751349917526 1.74575648534597 1.322351049115593 0.7499799667077489 0.5301085133609342 0.2237611443026157 0.3481187595900366 2.0753643051061554 0.1016925607045944 0.25417274074896434 1.88907260533746e-07 6.723751349917526 -0.5723710824078441 QQEQK(ub)YPQGVASQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QQEQKYPQGVASQR 14 1 F8W930;Q9Y6M1-1;Q9Y6M1;Q9Y6M1-5;Q9Y6M1-6;Q9Y6M1-3;Q9Y6M1-4 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 1 25494300.0 6169400.0 10541000.0 8783900.0 True False 7986409.917054989 9954384.08371629 7185320.330425089 1.0 1.2464153714998636 0.8996934048026796 22.92911569214978 -6.715825572824391 1.7741870504315025 1.1505801128214028 0.9003513270071405 0.49279591898526176 0.10374916368976587 0.36350257259658225 2.2337785593026487 0.04647192538721931 0.1172451692913547 1.9238642619345406e-07 6.715825572824391 -0.25022878581426233 QQEQPAATK(ub)IR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQEQPAATKIR 11 1 P40937 P40937 RFC5 Replication factor C subunit 5 1 5305500.0 1604500.0 1918800.0 1782200.0 True False 1553566.025758895 2684986.84640981 1315388.3551460446 1.0 1.7282734057590063 0.8466897018448224 20.567152125885798 -6.687277577807064 1.875860406514539 1.4577311623020597 0.8498122578104584 0.3578357126137408 0.30817914864046436 0.42253590695809196 2.880488456691571 0.1315257697858348 0.3437112125745358 2.054577000497505e-07 6.687277577807064 -0.6079189044916012 QQEQPAATK(ub)IR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQEQPAATKIR 11 1 P40937 P40937 RFC5 Replication factor C subunit 5 1 11841400.0 1572200.0 1744000.0 8525200.0 True False 2385142.3432160285 1432769.5740658068 6840190.483272106 1.0 0.6007061080194983 2.86783323549951 21.185643936906725 -6.861414202017293 1.1784674864733422 0.7824705934135352 2.9806745119709825 0.9553426762060246 0.20882026220159206 0.14535772703764474 0.3827766192509085 0.1381161442792407 0.3229570128013398 1.3758966016468175e-07 6.861414202017293 2.1982039185574473 up QQEQPAATK(ub)IR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQEQPAATKIR 11 1 P40937 P40937 RFC5 Replication factor C subunit 5 1 6700800.0 1604500.0 3651000.0 1445300.0 True False 1334212.8414020534 3631331.338333242 1747505.547687836 1.0 2.721703183816811 1.3097651989704095 20.347557401320074 -6.597126955477833 2.20192396257927 2.160031025974783 1.3142352918958053 0.012333796818190357 0.7447186526787493 0.6488361380688074 5.941203091287619 0.28121837920854775 0.8286964918957153 2.5285587254685867e-07 6.597126955477833 -0.8457957340789775 QQEQPAATK(ub)IR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QQEQPAATKIR 11 1 P40937 P40937 RFC5 Replication factor C subunit 5 1 10431200.0 1572200.0 1875900.0 6983100.0 True False 2035243.8926952132 1771504.5159513725 5712247.45265673 1.0 0.8704138714330799 2.8066648292908867 20.956770258999175 -6.890888250511602 1.0170923638497587 0.8981677902351467 2.9761409301442767 0.9814614864355607 0.12033465454775687 0.11842623266073664 0.21765148639040133 0.0900397331232768 0.2252049187045119 1.2856174230851992e-07 6.890888250511602 2.07797313990913 up QQEQQVPILEK(ub)FCFTPHTEEGCLSER ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQEQQVPILEKFCFTPHTEEGCLSER 26 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 9820000.0 1947200.0 4750300.0 3122500.0 True False 2552798.0567116225 4041573.756524374 2799413.653134994 1.0 1.5831936826724602 1.0966059950472733 21.283647984819325 -10.180180467841115 3.9739302923686055 0.9998252270564566 1.339899838843 0.39416209612954656 0.19864859207465144 140476107.59654045 219344741.25811225 317120.39781332755 0.07269793217453449 6.604189587952871e-11 10.180180467841115 0.3400746117865433 QQEQQVPILEK(ub)FCFTPHTEEGCLSER ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQEQQVPILEKFCFTPHTEEGCLSER 26 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 46247400.0 9228100.0 9779300.0 27240000.0 True False 13999702.364477696 8034107.508980362 21856002.060283843 1.0 0.5738770225119783 1.5611761944125626 23.7388928198206 -6.789430694163623 1.4988148565508594 0.7616635737876893 1.5714820782925547 0.79941059916307 0.18108285234970653 0.23620226934870356 1.0482939955079675 0.09510465434197116 0.22273607062695114 1.6239374819478397e-07 6.789430694163623 0.8098185045048654 QQEQQVPILEK(ub)FCFTPHTEEGCLSER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QQEQQVPILEKFCFTPHTEEGCLSER 26 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 9802600.0 1947200.0 3484200.0 4371200.0 True False 2667132.4611014035 3330256.5232913713 3338812.587689877 1.0 1.2486280947276718 1.2518360585327286 21.346858046342216 QQEQQVPILEK(ub)FCFTPHTEEGCLSER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QQEQQVPILEKFCFTPHTEEGCLSER 26 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 34022100.0 9228100.0 6313000.0 18481000.0 True False 11945957.363045856 5961676.000426995 15117647.63107345 1.0 0.4990538488668227 1.2655032302257363 23.510019141913048 -6.730361573475505 1.721883704481047 0.6986470608798832 1.2650768336684672 0.5608909008047109 0.21058096558122735 0.3355926440180355 1.9494443568406348 0.0969078625773461 0.2403744963074785 1.860537494307095e-07 6.730361573475505 0.5664297727885841 QQEVETELK(ub)MWDPHNDPNAQGDAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQEVETELKMWDPHNDPNAQGDAFK 25 1 P08621-2;P08621;P08621-3;M0QYR1 P08621-2 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 1 16864600.0 5621200.0 6706500.0 4536900.0 True False 5442758.082889311 9384440.423935475 3348549.7859174544 1.0 1.7242067865257213 0.6152303179603865 22.37590648259237 -6.730517926380391 1.721507659724459 1.43558520125578 0.615852255696563 0.561549572755244 0.3044278861388863 0.33529022879883746 1.9469453174873412 0.14012809998628986 0.3474926283201086 1.859867791845056e-07 6.730517926380391 -0.8197329455592169 QQEYDFK(ub)MAQALEELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQEYDFKMAQALEELR 16 1 Q03252 Q03252 LMNB2 Lamin-B2 1 7947700.0 2007800.0 3100600.0 2839300.0 True False 2632245.2435628576 2638002.5660441387 2545516.472488771 1.0 1.002187228752853 0.9670514093296659 21.327862479061956 -6.8920761185234785 1.0100521550771737 1.0017950055321811 0.9639039256384858 0.9821930082708364 0.002144748779071062 0.11747353779388642 0.21215251864174767 0.0016133998287098967 0.004053365471570856 1.282105849068132e-07 6.8920761185234785 -0.037891079893695334 QQEYDFK(ub)MAQALEELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQEYDFKMAQALEELR 16 1 Q03252 Q03252 LMNB2 Lamin-B2 1 24828100.0 11686000.0 7463300.0 5678800.0 True False 11315034.326592991 10443434.61059534 4191351.9196517477 1.0 0.922969768288799 0.37042326153629823 23.43173762554903 -6.932184708745285 0.728638348180264 1.0077590474816163 0.2504091668798628 0.9969504205858803 0.015484425883005781 0.09151930033730059 0.07223912086593927 0.014294994515689323 0.04940906776801681 1.1690020997950187e-07 6.932184708745285 -0.7573498806017535 down QQEYDFK(ub)MAQALEELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQEYDFKMAQALEELR 16 1 Q03252 Q03252 LMNB2 Lamin-B2 1 45548000.0 16261000.0 14232000.0 15055000.0 True False 24669125.83833855 11692188.404876465 12079372.651159078 1.0 0.47396038601033486 0.4896554799029967 24.556203258202295 -10.566223030545421 6.025233507420339 1.0012614883061453 0.48180793295666574 0.9993124421787378 0.006407495250349077 0.0001088102000334524 7.833615541007079e-06 0.0062172215564969095 0.0020680101996254155 2.715044608262664e-11 10.566223030545421 -0.5194535553494795 QQEYDFK(ub)MAQALEELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQEYDFKMAQALEELR 16 1 Q03252 Q03252 LMNB2 Lamin-B2 1 21656000.0 11686000.0 6256200.0 3713800.0 True False 9717426.777578311 6222496.608841528 4490338.409328924 1.0 0.6403440696048386 0.4620913038099542 23.212142900983306 -13.999999999995993 0.09154340603965742 2.829631161364474 0.027257386139373466 0.9998351250222263 0.002872693168787209 12.149987022903325 0.08828424768550233 4.303706225317387 0.39015772084548545 1.0000000000092275e-14 13.999999999995993 -2.8023737752251003 QQEYDFK(ub)MAQALEELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QQEYDFKMAQALEELR 16 1 Q03252 Q03252 LMNB2 Lamin-B2 1 49085000.0 16261000.0 15292000.0 17532000.0 True False 21050185.05223056 14440986.757251656 14341355.893511157 1.0 0.6860265941330256 0.6812935780814664 24.327329580294744 QQGVLALRPYLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQGVLALRPYLQK 13 1 P56192;P56192-2;H0YHV5 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 43351000.0 15863000.0 10696000.0 16792000.0 False True 20796546.617510512 9100198.492681453 15054524.920237884 1.0 0.437582193815735 0.7238954234623792 24.309840644913088 -10.39887715850282 5.011295129801894 1.0004074559799911 0.5807388086390101 0.7408704056681086 0.11688688654059301 0.0005326111942226553 6.388862195158749e-05 0.11328269472090617 0.037725080413456034 3.991377837165948e-11 10.39887715850282 -0.4196686473409811 QQGVLALRPYLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQGVLALRPYLQK 13 1 P56192;P56192-2;H0YHV5 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 21905600.0 7092800.0 2449800.0 12363000.0 False True 6867642.946402438 3428017.9155382332 9124759.417950017 1.0 0.49915494184711134 1.3286595545462876 22.711383603881895 -6.743169035237305 1.6746575635049945 0.7031190495926942 1.329540121918153 0.6193601028364314 0.21042481627015489 0.31206421374691695 1.7194988402660027 0.09934786762360007 0.24298901705414028 1.8064708781473758e-07 6.743169035237305 0.6264210723254588 QQGVLALRPYLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQGVLALRPYLQK 13 1 P56192;P56192-2;H0YHV5 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 21685700.0 5319900.0 12910000.0 3455800.0 False True 8070677.236786001 10606109.633709619 2772759.6152690547 1.0 1.314153610971724 0.3435597204446321 22.944258309141723 -6.81956822401358 1.3737406204930727 1.1694011655699612 0.32256598692624894 0.8833877687216442 0.1380875003767681 0.19404309661258023 0.7196624560297367 0.07899313909836649 0.18208782337703908 1.5150667807438633e-07 6.81956822401358 -0.8468351786437123 down QQGVLALRPYLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QQGVLALRPYLQK 13 1 P56192;P56192-2;H0YHV5 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 32576600.0 15863000.0 6834500.0 9879100.0 False True 21727979.78145623 6532529.191330836 7545860.046451114 1.0 0.300650555506593 0.3472876964332937 24.37305070643598 -9.901391934127577 6.9356335723976255 1.0000000162339255 0.3239691259699385 0.9964433209275937 0.019039533055465765 4.771932181200413e-09 7.525398940246276e-10 0.018434949160241187 0.006144982870279386 1.2548969561090781e-10 9.901391934127577 -0.6760308902639871 QQGVLALRPYLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQGVLALRPYLQK 13 1 P56192;P56192-2;H0YHV5 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 16234500.0 7092800.0 5274400.0 3867300.0 False True 5897977.464316921 5245985.7603135705 4675934.549625116 1.0 0.8894550364174947 0.7928030545919801 22.49178887931617 -6.972700776097041 0.18248388828849685 1.0723019705265895 0.6073359597954048 0.9999965009390616 0.00015824128179350101 0.0754357229950511 0.005771134851836588 0.00364139886856298 0.01076581510957699 1.0648764531596501e-07 6.972700776097041 -0.4649660107311847 QQHTETK(ub)SLYPSSEIQLNNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQHTETKSLYPSSEIQLNNK 20 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 17251600.0 6132600.0 4680800.0 6438200.0 True False 8039897.988182882 3982442.8856154988 5772036.82357525 1.0 0.49533500194516533 0.7179241368558462 22.938745765644256 -10.314069798792515 5.764472456033132 1.0000437296457876 0.6066295694005044 0.8063601192904065 0.09087163380312299 5.107567974994156e-05 6.077515890834475e-06 0.08799583251174976 0.029328693696845105 4.8521051199756644e-11 10.314069798792515 -0.3934141602452832 QQHTETK(ub)SLYPSSEIQLNNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQHTETKSLYPSSEIQLNNK 20 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 25502100.0 7923000.0 8256200.0 9322900.0 True False 7671488.7018309375 11552943.715514231 6880952.808995097 1.0 1.505958512688276 0.8969514362124831 22.87107513849224 -6.686187515845381 1.8801087480471024 1.3183375180816543 0.8991576927066701 0.3525367094967633 0.2141545543540168 0.42493868312204514 2.9092196892139617 0.09122843874232078 0.23870035217146593 2.0597403846898588e-07 6.686187515845381 -0.4191798253749842 QQHTETK(ub)SLYPSSEIQLNNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQHTETKSLYPSSEIQLNNK 20 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 67995000.0 11026000.0 23163000.0 33806000.0 True False 16727248.108573964 19029381.676654987 27124229.28230382 1.0 1.137627752822116 1.6215595719179072 23.995696783426997 -6.947838799795641 0.5820967199138233 0.9942596555869013 1.788949664354491 0.9990205084365209 0.008342347942709643 0.08436554765906741 0.03964625094839637 0.008720906249715945 0.040448868776244165 1.1276159238151168e-07 6.947838799795641 0.7946900087675898 QQHTETK(ub)SLYPSSEIQLNNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QQHTETKSLYPSSEIQLNNK 20 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 16993600.0 6132600.0 5364900.0 5496100.0 True False 8399987.947283525 5127860.978648154 4198034.375732599 1.0 0.6104605162328185 0.4997667141998939 23.001955827167148 -13.999999999935923 0.17647172643983894 2.9999500624364934 0.4085580296153179 0.9995028201794437 0.004783597415273204 12.161105249035115 0.13313225960872843 8.333384150487952 0.08519449753292654 1.0000000001475422e-14 13.999999999935923 -2.5913920328211755 QQHTETK(ub)SLYPSSEIQLNNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQHTETKSLYPSSEIQLNNK 20 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 21002300.0 7923000.0 8099000.0 4980300.0 True False 6588325.548412888 8055369.079474373 6021657.703694548 1.0 1.2226731997806168 0.9139890947169651 22.651480413926517 -6.713169693901898 1.7840370877310001 1.1364502407647972 0.914648614526529 0.48008424201757804 0.09378821764439127 0.36873936471046376 2.2896973843696413 0.041806237727193246 0.10579607238372402 1.9356654845914072e-07 6.713169693901898 -0.22180162623826816 QQHTETK(ub)SLYPSSEIQLNNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QQHTETKSLYPSSEIQLNNK 20 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 58430000.0 11026000.0 23238000.0 24166000.0 True False 14273374.35495323 21944784.872156307 19768035.964099366 1.0 1.5374629941336122 1.384958838218893 23.766823105519446 -10.006265734019209 4.749127681886006 0.9999915347336245 1.4612109160437747 0.9242125440551673 0.062259560996943956 42935831.09818799 3.3552415772588144 4132.156929358632 0.021313103728049242 9.856761902717873e-11 10.006265734019209 0.4612193813101503 QQIAK(ub)ENQQVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQIAKENQQVAK 12 1 Q9HD47-2;Q9HD47 Q9HD47-2 RANGRF Ran guanine nucleotide release factor 1 3850740.0 1915100.0 1146900.0 788740.0 True False 1854306.1987727394 1604863.1510044876 582145.3323071992 1.0 0.8654790411996983 0.3139423967263273 20.822448063005027 -6.94430778277188 0.6181914658588061 1.0060446293914587 0.14424800598834728 0.9986754112684108 0.0108030363066829 0.08585524843729345 0.046065399146643086 0.01089750392784842 0.04664508397194169 1.1368213395101855e-07 6.94430778277188 -0.8617966234031114 down QQIAK(ub)ENQQVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QQIAKENQQVAK 12 1 Q9HD47-2;Q9HD47 Q9HD47-2 RANGRF Ran guanine nucleotide release factor 1 2842690.0 1133700.0 1314300.0 394690.0 True False 1552859.5270905206 1256229.8801911063 301472.35089570796 1.0 0.8089784415624589 0.19414013027988092 20.566495897609606 -7.00468122471965 0.5843652609896544 1.0058490097175654 1.6846337505416244e-12 0.9991415128834527 0.010073982150764134 0.07627603780640482 0.037910120763176784 0.010744742660303194 0.046157825869824205 9.892789661193043e-08 7.00468122471965 -1.0058490097158808 down QQIAK(ub)ENQQVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQIAKENQQVAK 12 1 Q9HD47-2;Q9HD47 Q9HD47-2 RANGRF Ran guanine nucleotide release factor 1 4077140.0 1915100.0 1676600.0 485440.0 True False 1592490.5033150967 1667567.8230209546 586943.2595790385 1.0 1.0471445949282392 0.3685693938878727 20.602853338439303 -6.890238400185867 1.0209400331164111 1.0362524017832462 0.30992544001069694 0.9810515439715949 0.04258591208282076 0.11895117465000032 0.22070419697237112 0.031771918036701007 0.07927857151371906 1.2875425782768152e-07 6.890238400185867 -0.7263269617725492 down QQIESEVANLK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQIESEVANLKK 12 1 Q9UBW8 Q9UBW8 COPS7A COP9 signalosome complex subunit 7a 1 5369500.0 2115900.0 2110200.0 1143400.0 True False 1759464.6002633874 2098831.9337580944 1382479.6535157235 1.0 1.1928810238318546 0.7857388283394675 20.74670505724624 -6.777867756063845 1.5440278912261878 1.1095168828281656 0.7827184493354079 0.7598143259986953 0.0814973612749102 0.25390640918645235 1.195444762706009 0.041577486748148776 0.09828786736391365 1.6677549714921424e-07 6.777867756063845 -0.3267984334927577 QQIK(ub)PAVTIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQIKPAVTIK 10 1 Q86X83;Q86X83-2 Q86X83 COMMD2 COMM domain-containing protein 2 1 12310800.0 1686000.0 1927400.0 8697400.0 True False 2557785.2631104337 1583440.4111550662 6978355.077794166 1.0 0.619066985017147 2.7282802737349545 21.286463718277965 -6.860154721028751 1.1848241680217146 0.7932105854903964 2.830783459603721 0.9538368085494404 0.1971902418346159 0.14664933196677749 0.3910793373591096 0.12979094935905966 0.30304982969119554 1.3798925787927646e-07 6.860154721028751 2.0375728741133248 up QQILDEK(ub)PKIQTVNSVMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQILDEKPKIQTVNSVMR 18 2 A0A1B0GTC7 A0A1B0GTC7 1 25902300.0 10301000.0 12925000.0 2676300.0 True False 13504710.75502589 10996640.38125541 2399382.1488823663 1.0 0.8142818147484514 0.17767001399785007 23.686959404631647 -7.021149302705733 0.6103404803432333 1.0047164122765717 1.1022781633916842e-10 0.9989459210203568 0.0114326232411196 0.0755936698147323 0.04194876295954513 0.01189952078331693 0.046989411392032894 9.524686659741625e-08 7.021149302705733 -1.0047164121663439 down QQILDEK(ub)PKIQTVNSVMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQILDEKPKIQTVNSVMR 18 2 A0A1B0GTC7 A0A1B0GTC7 1 27679800.0 9544800.0 9215600.0 8919400.0 True False 9241805.54855938 12895437.138719115 6583141.563735619 1.0 1.395337423078466 0.7123220164226247 23.139743304242998 -6.749782076701515 1.650722464054138 1.2325263945743437 0.7109940334342789 0.6479855826569624 0.16612157994840787 0.30043492011259715 1.6106412443412081 0.07950127289116803 0.19304638844274757 1.7791719513339513e-07 6.749782076701515 -0.5215323611400647 QQILDEK(ub)PKIQTVNSVMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQILDEKPKIQTVNSVMR 18 2 A0A1B0GTC7 A0A1B0GTC7 1 79773000.0 20121000.0 38367000.0 21285000.0 True False 30525028.04213825 31520109.087260764 17078010.420453068 1.0 1.03259885768979 0.559475666881542 24.863489284771806 -6.890388775599887 1.0200981083873517 1.0251851010056434 0.5184741236085401 0.981145318073624 0.029626460434889017 0.11882754624386209 0.22001859171044866 0.022118051580112288 0.05521744648288964 1.2870968410168518e-07 6.890388775599887 -0.5067109773971034 QQILDEK(ub)PKIQTVNSVMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QQILDEKPKIQTVNSVMR 18 2 A0A1B0GTC7 A0A1B0GTC7 1 23011500.0 10301000.0 7551100.0 5159400.0 True False 14109558.074057901 7217467.433851523 3940855.9811784322 1.0 0.5115303679937144 0.2793039980766063 23.75016946615454 -10.30520147232222 0.16554782942040192 1.7666584617714303 3.055009652494352e-22 0.9996190192484912 0.005862603481907441 1.9778953988109285 0.08214666395603848 0.8159229221866067 0.18036667105118917 4.952204012156203e-11 10.30520147232222 -1.7666584617714303 QQILDEK(ub)PKIQTVNSVMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQILDEKPKIQTVNSVMR 18 2 A0A1B0GTC7 A0A1B0GTC7 1 28516500.0 9544800.0 14700000.0 4271700.0 True False 7936924.106334896 14620808.18227847 5164892.71989077 1.0 1.842125234712626 0.6507423594700099 22.920148579677274 -6.716857699231443 1.77123705471352 1.5140660574803366 0.6529927224410332 0.4974060088654436 0.3545125584409125 0.36143907019407734 2.2144584695008804 0.1590506010304338 0.4006669701064618 1.91929751396307e-07 6.716857699231443 -0.8610733350393034 QQILLSFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQILLSFK 8 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 68645000.0 21487000.0 21180000.0 25978000.0 False True 28169665.080404017 18020026.55899337 23290045.75857198 1.0 0.639696159239353 0.8267775173079177 24.747639075289925 -10.10405719821995 4.792859891582483 1.0000135518151543 0.7332368382710299 0.730530809272969 0.07637564461811583 1.106033614944045e-05 2.0675990105097596e-06 0.07395415488697084 0.024650133303877605 7.869421396242355e-11 10.10405719821995 -0.26677671354412436 QQILLSFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQILLSFK 8 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 52705900.0 23474000.0 9623900.0 19608000.0 False True 22728830.719017956 13466773.45797551 14472076.572608935 1.0 0.5924974154832972 0.6367277204673655 24.438020131065713 -10.356269194333692 8.87859400131998 1.0000007421182466 0.6146125682732669 0.9902177939444764 0.018056946396441176 2.652490236074537e-07 1.9249141706021646e-08 0.01748359677296768 0.005827854389731395 4.4028187333426975e-11 10.356269194333692 -0.3853881738449797 QQILLSFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQILLSFK 8 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 101785000.0 30325000.0 33540000.0 37920000.0 False True 46005242.05446262 27554524.95078391 30425095.379073583 1.0 0.5989431577854518 0.6613397521755301 25.45529492223112 -10.554797586024277 6.33626701145749 1.0005586171795955 0.6301414549805109 0.9791003529389496 0.025473302990516523 0.0002013081455937405 1.414442161933927e-05 0.02470002597076259 0.00822147318793051 2.787420013832952e-11 10.554797586024277 -0.3704171621990846 QQILLSFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QQILLSFK 8 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 72905000.0 21487000.0 24004000.0 27414000.0 False True 29431324.564341582 22943423.90938694 20939377.80905255 1.0 0.7795579794320485 0.7114656957853093 24.810849136812816 -13.999999999999998 0.16451714726679711 2.096650237739704 0.6477552534037293 0.9995252207377263 0.0026832636645688934 12.042868377420548 0.12831614561307567 4.2135654526820145 0.05841358539607204 1.0000000000000041e-14 13.999999999999998 -1.4488949843359746 QQILLSFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQILLSFK 8 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 51230000.0 23474000.0 11697000.0 16059000.0 False True 19519671.074522782 11633985.93932728 19416862.651573345 1.0 0.5960134212769621 0.9947330863026875 24.21842540649999 -10.894627889790355 10.391473077058112 1.016443374594126 0.7953732537898665 0.25990546829817807 0.1627766216210765 0.05802975699006638 0.000588435019125598 0.1474912555389578 0.0525359287241946 1.2745947056896771e-11 10.894627889790355 -0.22107012080425947 QQILLSFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QQILLSFK 8 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 136940000.0 30325000.0 63242000.0 43373000.0 False True 39256310.29511665 59722527.105814055 35479559.0445619 1.0 1.5213484572757552 0.903792505659286 25.226421244323568 -6.682913835981748 1.8914399084217326 1.3289983471040574 0.9060834259054492 0.3375100030985353 0.22082090747896654 0.4321073902900964 2.9912415629824824 0.09359166755001895 0.24593266580690884 2.0753252211031802e-07 6.682913835981748 -0.4229149211986082 QQIQSIQQSIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQIQSIQQSIER 12 0 P55769;B1AHD1;A0A3B3IUA2;A0A3B3IRU2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 0 19800600.0 4885500.0 3899100.0 11016000.0 False True 4730412.476687498 5456030.963537882 8130579.127083843 1.0 1.15339433726475 1.718788618783902 22.17353455672105 -6.9467562447675135 0.5933977988364756 0.9935277053275875 1.9072711506757885 0.9989214348581321 0.010151147329876969 0.08481521254929146 0.04156043270927343 0.010487570307379575 0.04741479246406835 1.1304302100103952e-07 6.9467562447675135 0.913743445348201 QQIQSIQQSIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQIQSIQQSIER 12 0 P55769;B1AHD1;A0A3B3IUA2;A0A3B3IRU2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 0 5885230.0 4885500.0 999730.0 0.0 False True 4062509.714346986 994344.2560591326 0.0 1.0 0.24476107775140793 0.0 21.953939832155328 -9.102925681053101 0.4676813704284296 1.129125557516249 4.521056035702401e-24 0.9965895873042705 0.024855078678422564 0.5845195636324815 0.20126827206436193 0.20320852750666488 0.052965881359218536 7.889951234089483e-10 9.102925681053101 -1.129125557516249 QQIQSIQQSIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QQIQSIQQSIER 12 0 P55769;B1AHD1;A0A3B3IUA2;A0A3B3IRU2 P55769 NHP2L1 NHP2-like protein 1;NHP2-like protein 1, N-terminally processed 0 8126100.0 2362800.0 3260200.0 2503100.0 False True 3058691.177751087 3078767.0040538707 2047561.4839748887 1.0 1.006563534903038 0.6694240657143965 21.544483021163682 -6.902460644677538 0.9455728057869733 1.0130864353108673 0.6322116040943332 0.9877514671009819 0.01742047900042224 0.10961689499545153 0.16737739287151723 0.013750802462560304 0.03624013722975907 1.2518127058811587e-07 6.902460644677538 -0.3808748312165341 QQISLATQMVR ddPTM_RPMI8226_Bortezomib_1h_R1 2 QQISLATQMVR 11 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 97324800.0 31605800.0 32694300.0 33024700.0 False True 41435509.87100257 27816437.881383263 29607620.839291383 1.0 0.6713188269670547 0.7145470378297772 25.304364339103508 -10.864400777127738 11.042295766812925 1.0097702689060148 0.6929329323984159 0.9853539134950249 0.017647843184517873 0.004125489631772229 5.0660835205564614e-05 0.016607072282147292 0.005695816895843149 1.3664672355780553e-11 10.864400777127738 -0.31683733650759893 QQISLATQMVR ddPTM_RPMI8226_Bortezomib_2h_R1 2 QQISLATQMVR 11 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 46131790.0 16235400.0 6295090.0 23601300.0 False True 15720016.11380865 8808752.265460664 17419411.506176826 1.0 0.5603526231581245 1.1081039217813147 23.90609936064393 -6.6930053388406545 1.8555931061595405 0.7251514311105932 1.1062899487443136 0.38458891627787106 0.18582768964410126 0.4102433038552738 2.7409464814026716 0.08004294477097394 0.20766227423528386 2.027657793097279e-07 6.6930053388406545 0.3811385176337204 QQISLATQMVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQISLATQMVR 11 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 77080000.0 17088000.0 45585000.0 14407000.0 False True 25923745.300137073 37450000.59276937 11559450.135187568 1.0 1.4446215297668177 0.4459020099663781 24.627770829023437 -6.785665456559955 1.5135073459946942 1.2499009733462711 0.43649585864551216 0.7870281687809845 0.18853717452423513 0.24186198655871724 1.0945211278114615 0.09807560057672263 0.23037455949122423 1.6380778710734158e-07 6.785665456559955 -0.813405114700759 down QQISLATQMVR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QQISLATQMVR 11 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 67314210.0 31605800.0 16310500.0 19397910.0 False True 43291318.374629594 15589848.178389274 14816523.170496743 1.0 0.3601148859334701 0.3422516044043557 25.3675744006264 QQISLATQMVR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 QQISLATQMVR 11 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 31161260.0 16235400.0 8680160.0 6245700.0 False True 13500454.450170713 8633398.255203148 7551646.99314601 1.0 0.6394894547489829 0.5593624289477543 23.686504636078205 -13.999999999999998 0.21132945389271343 3.0964379181579567 0.5127714363045104 0.9994907991090405 0.004324553706147796 12.778108785476412 0.14569766642782456 11.130159952525931 0.04702496836941486 1.0000000000000041e-14 13.999999999999998 -2.583666481853446 QQISLATQMVR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 QQISLATQMVR 11 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 71238100.0 25142400.0 29477200.0 16618500.0 False True 32547332.43079775 27836767.907458678 13594103.520209633 1.0 0.8552703348775299 0.417671818392904 24.956035969612724 -6.9512745474014945 0.5446701899162184 1.0062519980321538 0.24631939728171068 0.9992975542202227 0.0065610833498162685 0.08297792713753173 0.03387506817543279 0.007171037260747444 0.03626751627723579 1.1187304334526354e-07 6.9512745474014945 -0.7599326007504431 down QQLGTAVELEMAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQLGTAVELEMAK 13 0 Q9NYL9;H0YNJ8;H0YKU1 Q9NYL9 TMOD3 Tropomodulin-3 0 5978000.0 1848300.0 1472000.0 2657700.0 False True 2423139.198962661 1252383.3378110607 2382706.6984585696 1.0 0.5168433321318076 0.9833140000700742 21.208445853141434 -10.772642444293425 10.182315887562387 1.0012099763410118 0.7500786661009409 0.27679495182007285 0.19043585273733368 0.00525197719442185 0.00011726942749515907 0.18513259886072234 0.0614629071810418 1.6879421403619315e-11 10.772642444293425 -0.25113131024007096 QQLLIGAYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQLLIGAYAK 10 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 102848000.0 27798000.0 26195000.0 48855000.0 False True 36443447.196214885 22286808.107310265 43799953.25025147 1.0 0.6115450052602333 1.2018608726674094 25.119156094747385 -6.7292078983113175 1.7260673171173617 0.7660238358329641 1.2014622760243863 0.555606791305491 0.1633077308369637 0.33772785029124347 1.9708564178854742 0.07498715298498038 0.18624624967786016 1.865486462059308e-07 6.7292078983113175 0.4354384401914222 QQLLIGAYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQLLIGAYAK 10 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 60413000.0 22119000.0 8723000.0 29571000.0 False True 21416844.452328455 12206139.389844075 21825467.989015643 1.0 0.5699317384040212 1.0190795398265482 24.35224259395696 -10.985827082032275 12.259499267814316 1.137735861501642 0.7945056391114995 0.21820036015749533 0.18336382209634924 0.07217412235848682 8.343878023227767e-05 0.01856290155781754 0.05918041910634168 1.0331726901956852e-11 10.985827082032275 -0.34323022239014245 QQLLIGAYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQLLIGAYAK 10 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 134293000.0 32700000.0 59325400.0 42267600.0 False True 49608290.69022024 48738318.858534195 33913390.33345281 1.0 0.9824631766266934 0.6836234399855766 25.564077912608692 -6.918945438245958 0.8325266175470124 1.0068477059597203 0.6365851699091686 0.9938825923257021 0.011355438634249058 0.09879614829505295 0.10886413195371557 0.009729618438727453 0.028856715094194553 1.205187342260655e-07 6.918945438245958 -0.3702625360505517 QQLLIGAYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QQLLIGAYAK 10 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 73273000.0 27798000.0 19393000.0 26082000.0 False True 38075671.81270376 18536153.135924917 19921968.775651395 1.0 0.4868240599169263 0.523220414170198 25.182366156270277 -10.130918147922474 5.689306901754344 1.0000056248653406 0.5050222370435191 0.995961238984071 0.014858749403167408 1.0601340626863687e-06 1.619400982257044e-07 0.014387085633178302 0.004795640748639254 7.397446826170618e-11 10.130918147922474 -0.4949833878218215 QQLLIGAYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQLLIGAYAK 10 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 46538000.0 22119000.0 12342000.0 12077000.0 False True 18392928.537844826 12275511.19630482 14602244.86226114 1.0 0.6674038433328895 0.7939053768526274 24.132647869391235 -10.0675733901127 5.621082719133022 1.0000015454762274 0.7306546105169227 0.8580469275829088 0.051644034800752636 1.0002442930543217e-06 1.658982415290476e-07 0.05000440890274978 0.01666804055948442 8.559070623493287e-11 10.0675733901127 -0.26934693495930473 QQLLIGAYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QQLLIGAYAK 10 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 140398500.0 32700000.0 66494000.0 41204500.0 False True 42330794.61336572 62793550.44707628 33705703.7938729 1.0 1.483401174502157 0.7962454780669416 25.33520423470114 -6.71766618842403 1.7678032803526555 1.2948302555218056 0.7974621986050874 0.5014165446154342 0.2034778407172738 0.3598841463044261 2.1967316441235214 0.09143983646822106 0.23017286935910247 1.9157278443158428e-07 6.71766618842403 -0.49736805691671826 QQMFEFDTK(ub)TSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQMFEFDTKTSAK 13 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 141983000.0 36138000.0 49640000.0 56205000.0 True False 47377267.96088981 42233905.49520447 50389445.756429896 1.0 0.8914381793831757 1.0635785456862277 25.49769167129711 -6.736260551544954 1.7005244127735082 0.9351278885559039 1.0635968857117906 0.5879994949651122 0.04561874332965669 0.32461476049002763 1.8416917730175666 0.021235861414783296 0.05232357649727073 1.8354368571187424e-07 6.736260551544954 0.12846899715588667 QQMFEFDTK(ub)TSAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 QQMFEFDTKTSAK 13 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 216568700.0 68798900.0 62282000.0 85487800.0 True False 66614916.57811382 87151527.39633937 63095980.60097284 1.0 1.308288471608967 0.9471749548314061 25.989341929551284 -6.680634149563453 1.8998066726343064 1.1949471700830825 0.9485477139608071 0.3269851140481891 0.1306418825691061 0.43709641078028333 3.0507235693952106 0.05516968855234482 0.14537904050583528 2.0862476017164986e-07 6.680634149563453 -0.24639945612227543 QQMFEFDTK(ub)TSAK ddPTM_RPMI8226_Bortezomib_8h_R1 2 QQMFEFDTKTSAK 13 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 558656900.0 158527900.0 182449000.0 217680000.0 True False 240498414.24190092 149889550.46945652 174655452.5874666 1.0 0.6232454835177951 0.7262228864918527 27.841452140525035 -10.157079605558783 7.603216344759789 1.0000001268622183 0.6747341850048252 0.930081919080608 0.04204034872056737 9.038283800830952e-08 1.0011952508463929e-08 0.040705408689455644 0.013568464205292473 6.964988351668784e-11 10.157079605558783 -0.3252659418573931 QQMFEFDTK(ub)TSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QQMFEFDTKTSAK 13 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 178295600.0 43161400.0 68567200.0 66567000.0 True False 59119335.97297775 65537674.38259109 50845245.590399005 1.0 1.1085658068376654 0.8600442605383682 25.817126729469077 -6.787975107474297 1.5044859735552893 1.0608374111024823 0.857549099550874 0.7946775185688187 0.04609548150810157 0.2383819974986653 1.0659843077004756 0.02411951420958244 0.05655235610640001 1.6293894219352268e-07 6.787975107474297 -0.20328831155160831 QQMFEFDTK(ub)TSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 QQMFEFDTKTSAK 13 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 197604700.0 68798900.0 66556100.0 62249700.0 True False 57209333.65804656 66197549.078948505 75265824.45990697 1.0 1.157110996513726 1.315621414327044 25.76974720498556 -6.971015127228136 0.23266844840293116 0.9376483631418653 1.539627751946533 0.999989251413158 0.00042240337634219543 0.075974682522116 0.007841685503885799 0.0039939615348757495 0.01566281109416447 1.0690176428402527e-07 6.971015127228136 0.6019793888046676 QQMFEFDTK(ub)TSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 QQMFEFDTKTSAK 13 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 554402800.0 158527900.0 188114900.0 207760000.0 True False 205217491.60208485 177646140.44871306 169949811.79762033 1.0 0.8656481426698636 0.8281448646061405 27.612578462617485 -13.9999999998706 0.1790157648615457 1.6950066129478267 0.7980493860020086 0.9994993521776544 0.0016508243792508195 12.192167866701244 0.13411725584830217 2.9467110507658365 0.028237296933549476 1.0000000002979556e-14 13.9999999998706 -0.8969572269458181 QQNELAELHANLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQNELAELHANLAR 14 0 Q14980;Q14980-2;A0A087WY61;Q14980-3;Q14980-4 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 0 6486600.0 1868800.0 1802600.0 2815200.0 False True 2450014.897484945 1533659.1064797675 2523910.109305251 1.0 0.625979502432471 1.0301611275491274 21.224359090985615 -11.908297842292058 13.867317583490788 0.8985016195038711 0.8452632835562887 0.0 0.18816308599451328 0.0 0.0 0.0 0.054735187780263504 1.2351001023550455e-12 11.908297842292058 -0.05323833594758243 QQNQHPEK(ub)PGGK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQNQHPEKPGGKER 14 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 2 15094500.0 5490100.0 6367400.0 3237000.0 True False 5315819.780628804 8909936.025552342 2389132.592081554 1.0 1.6761170230075768 0.4494382222639883 22.34186076385542 -6.757059849289849 1.623401550992692 1.3941577160461305 0.44557547749314813 0.6789004934969092 0.2842706567064071 0.2878865073909199 1.4946114968667823 0.13820378033466862 0.333114830644757 1.7496055622225616e-07 6.757059849289849 -0.9485822385529823 QQNQHPEK(ub)PGGK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQNQHPEKPGGKER 14 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 2 13051500.0 5490100.0 5790300.0 1771100.0 True False 4565261.402668381 5759106.504615442 2141428.8213588363 1.0 1.2615064060185606 0.46907036256613427 22.122266039289695 -6.817765451452213 1.3814034679336404 1.1412774404775017 0.4525695515180935 0.8791971137357079 0.11458748048672254 0.19639623916221752 0.7369975052700286 0.06519269771202728 0.15036367964440994 1.5213689505717337e-07 6.817765451452213 -0.6887078889594082 down QQPDTEAVLNGK(ub)GLGTGTLYIAESR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQPDTEAVLNGKGLGTGTLYIAESR 25 1 P54105;E9PMI6;E9PJF4;J3KN38 P54105 CLNS1A Methylosome subunit pICln 1 49573000.0 19683000.0 18405000.0 11485000.0 True False 19058173.93892947 25754212.480807077 8476733.957385428 1.0 1.3513473307219557 0.44478206487927463 24.183906558094396 -6.801632620256663 1.449396645519653 1.1934537229928859 0.43177969368504765 0.8368505993378179 0.1507461439055151 0.2184360358367872 0.905789038498033 0.08181764485937909 0.19007802529686474 1.5789463721649189e-07 6.801632620256663 -0.7616740293078382 down QQPDTEAVLNGK(ub)GLGTGTLYIAESR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQPDTEAVLNGKGLGTGTLYIAESR 25 1 P54105;E9PMI6;E9PJF4;J3KN38 P54105 CLNS1A Methylosome subunit pICln 1 76893000.0 24729000.0 19833000.0 32331000.0 True False 37515700.9320629 16293646.194063742 25940763.678819302 1.0 0.43431538767114786 0.6914641879088271 25.160991177583238 -10.397220333201364 6.0049047870965655 1.000104943717944 0.5628897877899939 0.7939240458994081 0.1049805580918667 0.0001475286744018127 1.4809090538846685e-05 0.10167117531504563 0.03388232943044657 4.0066339511308626e-11 10.397220333201364 -0.43721515592795 QQPDTEAVLNGK(ub)GLGTGTLYIAESR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQPDTEAVLNGKGLGTGTLYIAESR 25 1 P54105;E9PMI6;E9PJF4;J3KN38 P54105 CLNS1A Methylosome subunit pICln 1 44601100.0 19683000.0 18102000.0 6816100.0 True False 16367286.604747033 18004480.93303431 8241314.995914399 1.0 1.100028451130833 0.5035235952625254 23.964311833528672 -6.863791769718295 1.1665366800144454 1.0549148744559003 0.4724902593799195 0.9580757703102551 0.05340696156487957 0.14294447332563973 0.36751237507802037 0.03565082008119233 0.08360167440005951 1.3683847649602244e-07 6.863791769718295 -0.5824246150759808 QQPDTEAVLNGK(ub)GLGTGTLYIAESR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QQPDTEAVLNGKGLGTGTLYIAESR 25 1 P54105;E9PMI6;E9PJF4;J3KN38 P54105 CLNS1A Methylosome subunit pICln 1 97920000.0 24729000.0 29231000.0 43960000.0 True False 32012177.98146548 27604269.15388586 35959731.06769051 1.0 0.8623052505164839 1.123314105291761 24.932117499675687 -6.763369035238943 1.5997999041175477 0.9203553022052591 1.1244295543800236 0.7045729163580827 0.057946122720211705 0.27728956614240896 1.3994268695299765 0.028568712138553384 0.06842838193650666 1.7243720099539223e-07 6.763369035238943 0.2040742521747645 QQPTQFINPETPGYVGFANLPNQVHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQPTQFINPETPGYVGFANLPNQVHR 26 0 Q15019;Q15019-2;Q15019-3;C9JB25;C9J938;C9IZU3;C9JZI2;F8WB65;C9JFT1;A0A1B0GXJ2;C9JSE7;C9JT15 Q15019 SEPT2 Septin-2 0 8687800.0 1723800.0 1368800.0 5595200.0 False True 1669078.9125604157 1915368.9781977024 4129649.267597993 1.0 1.1475604681024163 2.4742085209518287 20.67062073497031 -6.927991166726761 0.7630983464456004 0.9782517039245923 2.7331371804050764 0.9961286086878715 0.04124666219496493 0.09369408640929462 0.08288811095635484 0.037138295825441335 0.12139139423145393 1.1803446428660732e-07 6.927991166726761 1.7548854764804842 up QQQELFAK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQQELFAKAR 10 1 Q01658 Q01658 DR1 Protein Dr1 1 10456200.0 4356100.0 4983200.0 1116900.0 True False 3622290.1579504465 4956354.512512245 1350438.626037879 1.0 1.3682930677526495 0.3728134873662302 21.788470685095884 -6.80653900111814 1.429035631680932 1.201551125884428 0.3567418103783186 0.8506036004257814 0.15884299824870762 0.21155367837370545 0.8521020603101925 0.08741771909948826 0.20255029469625926 1.5612088298236872e-07 6.80653900111814 -0.8448093155061094 down QQQFNVQALVAVGDHASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQQFNVQALVAVGDHASK 18 0 P14868;C9J7S3;C9JLC1;H7C278;C9JQM9 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 12694200.0 4685200.0 2497300.0 5511700.0 False True 4536470.890548814 3494484.9132474596 4068020.422544294 1.0 0.7703091230074449 0.8967368072436044 22.113138970671258 -10.416268404583803 7.632950512647584 1.0000058311857027 0.8335229651255248 0.6980555966131388 0.05161388595671718 5.121970243340876e-06 3.916893328436072e-07 0.04997668009325861 0.016658310061951204 3.8347017831877375e-11 10.416268404583803 -0.16648286606017793 QQQFNVQALVAVGDHASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQQFNVQALVAVGDHASK 18 0 P14868;C9J7S3;C9JLC1;H7C278;C9JQM9 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 49575400.0 9262400.0 25143000.0 15170000.0 False True 14051737.972143607 20656035.20684436 12171642.85075279 1.0 1.4699986042860476 0.866201951308945 23.7442452436774 -6.698915527256714 1.8343151321218092 1.2921455990703117 0.8680066575291653 0.4126835388356841 0.19842987082508248 0.3977506628894312 2.6010183342917053 0.08631806483755375 0.22231972572320266 2.0002508919568107e-07 6.698915527256714 -0.4241389415411464 QQSAQSQVSTTAENK(ub)TTTTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QQSAQSQVSTTAENKTTTTAR 21 1 A0A087WV29;Q9H0A0-2;Q9H0A0 A0A087WV29 NAT10 N-acetyltransferase 10 1 2991710.0 619010.0 0.0 2372700.0 True False 847874.7251162592 0.0 1812317.1272903974 1.0 0.0 2.137482193542089 19.693491594408428 -6.779477451907029 1.5378572313401124 0.4333959935335427 2.1541579283291914 0.7655716905966551 0.4227962722075466 0.25137547257140685 1.1742197018582265 0.21654368903624935 0.5111863561444054 1.6615849431943102e-07 6.779477451907029 1.7207619347956487 QQSHFAMMHGGTGFAGIDSSSPEVK ddPTM_RPMI8226_Bortezomib_1h_R1 2 QQSHFAMMHGGTGFAGIDSSSPEVK 25 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 116114100.0 31268700.0 40762000.0 44083400.0 False True 40993568.50652152 34680468.4890315 39522072.64583225 1.0 0.8459977931297761 0.9641042262408753 25.288894246830633 -10.207119664840056 5.127740111606148 1.0000081621598131 0.9050510097919806 0.46286582108199803 0.04821674941057746 4.4995430328586366e-06 6.957576637265035e-07 0.04668967938438325 0.01556188895625842 6.206979844885126e-11 10.207119664840056 -0.09495715236783253 QQSHFAMMHGGTGFAGIDSSSPEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQSHFAMMHGGTGFAGIDSSSPEVK 25 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 49237900.0 12796000.0 4483900.0 31958000.0 False True 12389797.984176276 6274344.6532295905 23587241.080550574 1.0 0.50641218373721 1.9037631695589545 23.562649328719665 -6.811248092980299 1.409377711035288 0.7313916624053839 1.9288888019731676 0.863027681179888 0.21413871339159052 0.20511124165664188 0.8027695951972047 0.11946408400221693 0.27617939068996833 1.5443719569927897e-07 6.811248092980299 1.1974971395677838 QQSHFAMMHGGTGFAGIDSSSPEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQSHFAMMHGGTGFAGIDSSSPEVK 25 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 91484500.0 8264600.0 77109000.0 6110900.0 False True 12538002.423192475 63348296.494633205 4903077.93649738 1.0 5.052503130598631 0.39105734478307264 23.57980417792437 -6.676862056066358 1.9129831255348841 3.5712404504105186 0.4091839589985334 0.3098488398912431 1.7187354883863986 0.44553004704973825 3.1494476662131143 0.7216508390526047 1.9110287379247037 2.1044467640919984e-07 6.676862056066358 -3.162056491411985 QQSHFAMMHGGTGFAGIDSSSPEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QQSHFAMMHGGTGFAGIDSSSPEVK 25 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 106044800.0 31268700.0 28467100.0 46309000.0 False True 42829583.39484463 27209329.393888906 35371767.96379271 1.0 0.6352928802282974 0.8258723330951285 25.352104308353525 -10.506322055531207 7.571208640358742 1.0000492815744388 0.7305826066617181 0.7271215800784948 0.07780373583042215 6.473417217631488e-05 4.221036979318741e-06 0.07534686648640289 0.02511104776199552 3.116577596851482e-11 10.506322055531207 -0.2694666749127207 QQSHFAMMHGGTGFAGIDSSSPEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQSHFAMMHGGTGFAGIDSSSPEVK 25 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 27200500.0 12796000.0 8556500.0 5848000.0 False True 10640440.958915977 8510404.436167736 7070789.761903046 1.0 0.7998168937760598 0.6645203698985988 23.34305460415394 -7.920561648513997 0.07456765870853241 1.5893035629625032 2.2951791286080258e-07 0.999997424017875 0.00022110826033314813 0.12013198934081118 0.011203130036101608 0.10922083928940109 0.12336538044739624 1.2007106189046655e-08 7.920561648513997 -1.5893033334445903 QQSHFAMMHGGTGFAGIDSSSPEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QQSHFAMMHGGTGFAGIDSSSPEVK 25 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 38869600.0 8264600.0 20129000.0 10476000.0 False True 10698687.619621469 19008803.45518694 8569475.49283725 1.0 1.77674160897311 0.8009838026414353 23.35093050001682 -6.69465484526418 1.8501933343727737 1.484829850089351 0.8041813863324291 0.39220566172850957 0.32820305876459543 0.4067096878131918 2.7028840678802797 0.14173188114806617 0.3668857271769346 2.0199710942079014e-07 6.69465484526418 -0.680648463756922 QQTDIAVNWAGGLHHAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQTDIAVNWAGGLHHAK 17 0 Q13547;Q5TEE2 Q13547 HDAC1 Histone deacetylase 1 0 10739100.0 3160200.0 4477100.0 3101800.0 False True 4143052.8034203365 3809134.131599115 2780855.4905665726 1.0 0.9194027477647517 0.6712092803332873 21.98226277698071 -6.950861553527428 0.549302009123435 1.003446725248633 0.5755194512854043 0.9992671814105036 0.003787725604694339 0.08314159262017956 0.03454455912638886 0.004114803927308442 0.02058706007987235 1.1197948001177224e-07 6.950861553527428 -0.4279272739632287 QQTDIAVNWAGGLHHAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQTDIAVNWAGGLHHAK 17 0 Q13547;Q5TEE2 Q13547 HDAC1 Histone deacetylase 1 0 8572500.0 2958500.0 1522300.0 4091700.0 False True 2864584.0369010237 2130162.328689629 3019961.0216311663 1.0 0.7436201211936133 1.054240679529246 21.449894231354005 -6.687466596876528 1.8752307526424565 0.8388863438665154 1.0531405226719948 0.35864352413521294 0.10848709108511677 0.4221565708927958 2.876133028539579 0.0463137590551391 0.12099913353209965 2.053682976398594e-07 6.687466596876528 0.21425417880547937 QQTDIAVNWAGGLHHAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQTDIAVNWAGGLHHAK 17 0 Q13547;Q5TEE2 Q13547 HDAC1 Histone deacetylase 1 0 27015200.0 4600800.0 15291000.0 7123400.0 False True 6979749.963534107 12562201.580871709 5715456.867702869 1.0 1.7998068192275183 0.8188626953061969 22.73474392483783 -6.68987547690547 1.8665035045512623 1.5014687647836427 0.8222220584455712 0.3700422156651825 0.33826771225049934 0.41691370990952037 2.8158768091341857 0.1449759515107063 0.37763611459648944 2.0423234459599218e-07 6.68987547690547 -0.6792467063380715 QQTDIAVNWAGGLHHAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QQTDIAVNWAGGLHHAK 17 0 Q13547;Q5TEE2 Q13547 HDAC1 Histone deacetylase 1 0 18633100.0 4600800.0 7755300.0 6277000.0 False True 5955826.295326392 7323710.737543396 5134650.407458909 1.0 1.2296716482967944 0.8621222569046599 22.50587024693028 -6.737732071323074 1.6948726427147889 1.1370092584406573 0.8620057881495466 0.5947901052251334 0.09650471127998732 0.32192637390154 1.81486067916135 0.04505984931906927 0.11085472109204003 1.8292283713683883e-07 6.737732071323074 -0.2750034702911106 QQTNNQTEVVK(ub)IIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQTNNQTEVVKIIEK 15 1 Q5BKZ1;A0A0A0MRN4;Q5BKZ1-3 Q5BKZ1 ZNF326 DBIRD complex subunit ZNF326 1 6860300.0 2874500.0 2706800.0 1279000.0 True False 2783250.5709217465 3787639.3557755277 943991.5308224609 1.0 1.3608689764936082 0.3391687190096698 21.408339367017494 -6.811228973682765 1.4093153077162641 1.1963794891073227 0.32077487802196286 0.8630484981315572 0.15656056903290416 0.20511124332291186 0.8026799037215411 0.08734485743580767 0.20194075445900062 1.5444399476261977e-07 6.811228973682765 -0.8756046110853599 down QQTNNQTEVVK(ub)IIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QQTNNQTEVVKIIEK 15 1 Q5BKZ1;A0A0A0MRN4;Q5BKZ1-3 Q5BKZ1 ZNF326 DBIRD complex subunit ZNF326 1 5058980.0 2874500.0 1223800.0 960680.0 True False 2390274.11194154 1217207.1464947192 1161553.746317549 1.0 0.5092332885227219 0.4859500174120438 21.18874464245177 QQTNTLLNLVWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QQTNTLLNLVWR 12 0 Q15386;Q15386-2;Q15386-3 Q15386 UBE3C Ubiquitin-protein ligase E3C 0 4883590.0 933990.0 2009600.0 1940000.0 False True 1224469.934772026 1709775.5133594463 1739267.409794041 1.0 1.396339317778166 1.4204247571973752 20.223725920206217 -11.849512895397812 0.44272524627753634 1.0860436283216271e-12 1.4206913046300989 0.9998072973854281 0.002675894081176533 5.287653741494569 0.2212979564173441 4.971185124562419 0.005526148452401041 1.4141227352528251e-12 11.849512895397812 1.4206913046290128 QQTNTLLNLVWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QQTNTLLNLVWR 12 0 Q15386;Q15386-2;Q15386-3 Q15386 UBE3C Ubiquitin-protein ligase E3C 0 5141590.0 933990.0 1468900.0 2738700.0 False True 1279311.3431307008 1403999.1409972731 2091875.4652970072 1.0 1.097464779419089 1.6351574435178684 20.28693598172911 -6.937637400022395 0.6811907579608906 0.9936470754266651 1.7706031672060398 0.9978377612522893 0.012987057457626823 0.08886118776230181 0.059643572539871424 0.012426140120427634 0.04678022382982425 1.1544166980449147e-07 6.937637400022395 0.7769560917793747 QQVPSGESAILDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQVPSGESAILDR 13 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 12692900.0 3511700.0 1022600.0 8158600.0 False True 3400223.0057073943 1430929.5127885528 6021617.907246379 1.0 0.4208340189413127 1.7709479340439969 21.697197938827596 -6.790129175547573 1.4956735087213706 0.6763493988552243 1.7853829314680107 0.8017552821711129 0.2462358206266821 0.23517729020299047 1.0393057106781485 0.129578699693336 0.30336567012356885 1.621327781642586e-07 6.790129175547573 1.1090335326127865 QQVSLLK(ub)EK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QQVSLLKEK 9 1 Q12904;Q12904-2;A0A5F9ZHC5;D6R937 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 1 8106260.0 2681070.0 2449940.0 2975250.0 True False 2595960.9003935186 3428213.818268318 2195942.7694132314 1.0 1.3205953208881687 0.8459074900089408 21.307837223372637 -6.724797315882124 1.7421634710012681 1.1940446160586735 0.8464467224399961 0.5349662369932082 0.1348349504076418 0.34609797285712096 2.055394461203974 0.06139456081101074 0.15325412191124851 1.8845283888433034e-07 6.724797315882124 -0.34759789361867743 QQVSLLK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QQVSLLKEK 9 1 Q12904;Q12904-2;A0A5F9ZHC5;D6R937 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 1 17345100.0 6852300.0 7729800.0 2763000.0 True False 10395440.070232281 6350356.796796938 2216891.8389340807 1.0 0.6108790733142134 0.21325618001321855 23.309447497319145 -7.588421558366425 0.35531735476214693 1.0599541107300883 7.621526355005896e-12 0.9991952409157098 0.009111691863010613 0.12321946632274149 0.045902915860006215 0.024387958994124343 0.07093164868310466 2.579754873899197e-08 7.588421558366425 -1.0599541107224668 down QQVSLLK(ub)EK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QQVSLLKEK 9 1 Q12904;Q12904-2;A0A5F9ZHC5;D6R937 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 1 4997060.0 2446330.0 816950.0 1733780.0 True False 3350804.3105824804 780854.4477076188 1324296.8723199505 1.0 0.2330349299245949 0.3952176103324112 21.6760760038833 -10.295122917577991 8.333970467573186 1.0000009158395489 0.3141262701984945 0.9597523026066876 0.06621080201933806 1.1266640735390524e-06 9.536897665296954e-08 0.06410841839076906 0.02136944446332772 5.068472359201878e-11 10.295122917577991 -0.6858746456410544 QQWQQLYDTLNAWK(ub)QNLNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QQWQQLYDTLNAWKQNLNK 19 1 Q7L2H7;Q7L2H7-2;H0YCQ8 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 1 27935400.0 9679900.0 10478000.0 7777500.0 True False 12530821.369355319 9894890.089097755 6362074.803889062 1.0 0.7896441739482576 0.5077141087852229 23.57897764763892 -6.967061033225165 0.32071831531979167 1.0382862545586102 0.2499689355746739 0.9999495413287879 0.001432619467695135 0.07726837791627224 0.012429817427306417 0.0042611389892326995 0.024783500448382904 1.0787951039753982e-07 6.967061033225165 -0.7883173189839363 QREEIK(ub)FSHTE ddPTM_RPMI8226_Bortezomib_1h_R1 1 QREEIKFSHTE 11 2 A0A494C105;Q9H3U5-4;Q9H3U5-3;Q9H3U5;Q9H3U5-5;Q9H3U5-6 A0A494C105 MFSD1 Major facilitator superfamily domain-containing protein 1 1 28424600.0 7895700.0 11693000.0 8835900.0 True False 10351339.162067555 9948449.97895701 7921645.827937717 1.0 0.9610785448334134 0.7652773910612996 23.303314086766665 -6.939668962605443 0.6626367876831527 1.002210796726324 0.7129864380069466 0.9981202032194921 0.004453238941922783 0.08791800969003544 0.05530000146036847 0.00432409259960208 0.016876946629701767 1.1490291257760614e-07 6.939668962605443 -0.28922435871937746 QREEIK(ub)FSHTE ddPTM_RPMI8226_Bortezomib_2h_R1 1 QREEIKFSHTE 11 2 A0A494C105;Q9H3U5-4;Q9H3U5-3;Q9H3U5;Q9H3U5-5;Q9H3U5-6 A0A494C105 MFSD1 Major facilitator superfamily domain-containing protein 1 1 31096900.0 8649900.0 12010000.0 10437000.0 True False 8375313.659215874 16805655.631322615 7703236.596711502 1.0 2.0065702987529686 0.9197549978603078 22.997711790363645 -6.663339612275538 1.960714254736836 1.646106976431835 0.9242209141832612 0.2500714943782689 0.42823092802969054 0.47655032788674256 3.5251634323444168 0.17622709570307002 0.47500857412781894 2.1710028207382482e-07 6.663339612275538 -0.7218860622485738 QREEIK(ub)FSHTE ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QREEIKFSHTE 11 2 A0A494C105;Q9H3U5-4;Q9H3U5-3;Q9H3U5;Q9H3U5-5;Q9H3U5-6 A0A494C105 MFSD1 Major facilitator superfamily domain-containing protein 1 1 26770800.0 7895700.0 9104700.0 9770400.0 True False 10814953.663269483 8702424.24878335 7462832.747704336 1.0 0.8046658838991742 0.6900475933660393 23.366524148289557 -13.99999949975052 0.057691921124120187 2.2758843786394234 0.1432596819750539 0.9999598781529977 0.0008104995946680983 12.487747522630103 0.06051919918467828 2.349359136356609 0.5149179495237919 1.0000011518676569e-14 13.99999949975052 -2.1326246966643696 QREEIK(ub)FSHTE ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QREEIKFSHTE 11 2 A0A494C105;Q9H3U5-4;Q9H3U5-3;Q9H3U5;Q9H3U5-5;Q9H3U5-6 A0A494C105 MFSD1 Major facilitator superfamily domain-containing protein 1 1 31967900.0 8649900.0 13241000.0 10077000.0 True False 7192775.105542925 13169668.104867268 12184054.109216306 1.0 1.8309578586321162 1.693929523783801 22.77811706579792 -10.395559056041874 5.635339580207566 0.9997007888323679 1.7624436912079615 0.9763478272560172 0.05594158344694436 0.00021037704041135255 2.2564705538911405e-05 0.054185635424598116 0.018055068420872556 4.0219896063721725e-11 10.395559056041874 0.7627429023755936 QREEIK(ub)FSHTE ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QREEIKFSHTE 11 2 A0A494C105;Q9H3U5-4;Q9H3U5-3;Q9H3U5;Q9H3U5-5;Q9H3U5-6 A0A494C105 MFSD1 Major facilitator superfamily domain-containing protein 1 1 44071000.0 16570000.0 14409000.0 13092000.0 True False 21450191.64353117 13607126.483471045 10709390.335263966 1.0 0.6343592033861668 0.4992678160287507 24.354487201537147 -13.999999999999998 0.13834691266327098 2.7442215348931973 0.3287081552712074 0.9996096056237621 0.0041793405635126655 11.932719776074409 0.11641212137814863 5.624243738588358 0.15231557223994638 1.0000000000000041e-14 13.999999999999998 -2.41551337962199 QRHELLLGAGSGPGAGQQQATPGALLQAGPPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QRHELLLGAGSGPGAGQQQATPGALLQAGPPR 32 1 Q96DI7;Q96DI7-2 Q96DI7 SNRNP40 U5 small nuclear ribonucleoprotein 40 kDa protein 0 10048000.0 3068100.0 3582000.0 3397900.0 False True 4022308.8115226626 3047579.5625266386 3046317.9029583335 1.0 0.75766921569927 0.7573555501834123 21.939592417687855 QRHELLLGAGSGPGAGQQQATPGALLQAGPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QRHELLLGAGSGPGAGQQQATPGALLQAGPPR 32 1 Q96DI7;Q96DI7-2 Q96DI7 SNRNP40 U5 small nuclear ribonucleoprotein 40 kDa protein 0 10923600.0 3289400.0 1510400.0 6123800.0 False True 3184979.797526527 2113510.5966319465 4519793.069937911 1.0 0.6635868140429997 1.4190963074390635 21.602852790753715 -6.785650008504797 1.513557970109547 0.8109073187532005 1.426207678513687 0.7869435780712815 0.142651658362829 0.24190586594414948 1.0947910602008055 0.07420309631855623 0.17430213789717933 1.6381361392956065e-07 6.785650008504797 0.6153003597604865 QRHELLLGAGSGPGAGQQQATPGALLQAGPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QRHELLLGAGSGPGAGQQQATPGALLQAGPPR 32 1 Q96DI7;Q96DI7-2 Q96DI7 SNRNP40 U5 small nuclear ribonucleoprotein 40 kDa protein 0 11096200.0 3068100.0 3614900.0 4413200.0 False True 4202459.482284931 3455181.765124271 3370893.0527070304 1.0 0.8221808632990425 0.8021238674439838 22.002802479210747 -13.999999998564748 0.30804782260482433 2.6993730916948944 0.7975885283271461 0.999667693013271 0.0016211202814727897 17.132157211492014 0.17652831556889495 18.641073189465512 0.007006630526612366 1.0000000033047897e-14 13.999999998564748 -1.9017845633677481 QRPLQAYKPGALTFLLSMGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QRPLQAYKPGALTFLLSMGR 20 2 Q9BRQ8-2;Q9BRQ8 Q9BRQ8-2 AIFM2 Apoptosis-inducing factor 2 0 35307100.0 8403100.0 11654000.0 15250000.0 False True 12748117.048898764 9574252.646882402 12235830.81568754 1.0 0.751032690565817 0.9598147529359659 23.603780834838634 -10.07062363357408 6.280364371845334 1.0000002105109747 0.8554237219179455 0.3900063967954641 0.08523492004213873 2.511900873921767e-07 3.710641029555456e-08 0.08252847636141962 0.027509452153209487 8.499167071557367e-11 10.07062363357408 -0.14457648859302918 QRPLQAYKPGALTFLLSMGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QRPLQAYKPGALTFLLSMGR 20 2 Q9BRQ8-2;Q9BRQ8 Q9BRQ8-2 AIFM2 Apoptosis-inducing factor 2 0 32239100.0 8403100.0 11984000.0 11852000.0 False True 10877978.599864628 11317079.865217349 9695057.611789543 1.0 1.0403660718139476 0.8912554407774064 23.374907156931084 -6.834598477194236 1.307072567277604 1.0215115842761233 0.886848125496807 0.9147794664084128 0.0183830130900491 0.17521339547468198 0.5837605654367024 0.011036405439601759 0.02540294537113509 1.463529641474892e-07 6.834598477194236 -0.1346634587793163 QSDENNLK(ub)DPGGSEFDSISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QSDENNLKDPGGSEFDSISK 20 1 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 160669810.0 68444810.0 58991000.0 33234000.0 True False 89731808.73048286 50189772.74511695 29795264.483038764 1.0 0.5593308934166947 0.33204796498119615 26.419116156190118 -10.091875466774873 0.15029610310482774 1.7297228958309279 1.1258962112612398e-21 0.9997274716655622 0.0045776162739199905 1.684328395785416 0.07103478611448172 0.676765428881176 0.19780182954131748 8.093279393576302e-11 10.091875466774873 -1.7297228958309279 QSDENNLK(ub)DPGGSEFDSISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QSDENNLKDPGGSEFDSISK 20 1 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 253471100.0 117310000.0 110631100.0 25530000.0 True False 113586058.2622475 154806675.16356486 18842927.116417084 1.0 1.3629020808711152 0.1658911965490741 26.759210526069495 -6.825358205856519 1.3483438248519977 1.1946186509265102 0.13658896765786047 0.8963092045802429 0.16137232414171077 0.1866043941567297 0.6650686677843621 0.09400745233490322 0.21644643254561835 1.4950020705254012e-07 6.825358205856519 -1.0580296832686498 down QSDENNLK(ub)DPGGSEFDSISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QSDENNLKDPGGSEFDSISK 20 1 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 386551500.0 164831300.0 174866200.0 46854000.0 True False 250061132.88216788 143659960.37414327 37593286.36316227 1.0 0.5744993582902695 0.15033638346698497 27.89770559528359 -7.73424726388682 0.4047935586321029 1.0455262289991996 2.977873366248051e-18 0.9980900681585663 0.015159346473236864 0.11710856848027033 0.06794910840557485 0.030188132754964406 0.0769296108913464 1.8439652657514103e-08 7.73424726388682 -1.0455262289991996 down QSDENNLK(ub)DPGGSEFDSISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QSDENNLKDPGGSEFDSISK 20 1 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 124804810.0 68444810.0 56360000.0 0.0 True False 93750705.90844184 53869828.842403345 0.0 1.0 0.5746071810383307 0.0 26.48232621771301 -7.716383364489295 0.6426086553237005 1.0009079451782108 4.494814299976785e-19 0.9875643143939679 0.0456945996344021 0.11969977365348493 0.15187143853125123 0.042878430960622445 0.07789419814885282 1.9213949084092894e-08 7.716383364489295 -1.0009079451782108 down QSDENNLK(ub)DPGGSEFDSISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QSDENNLKDPGGSEFDSISK 20 1 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 219349200.0 117310000.0 88846200.0 13193000.0 True False 97548462.71416329 88367567.88601007 15951595.302460149 1.0 0.9058837569275171 0.16352482508311328 26.53961580150377 -6.9303603202823165 0.7438320388078503 1.0111396180288152 0.009716310429201744 0.9966085070074554 0.021787045446487678 0.09245130952797397 0.07676778250971855 0.019891692762333664 0.06703817361445694 1.173923184162853e-07 6.9303603202823165 -1.0014233075996135 down QSDENNLK(ub)DPGGSEFDSISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QSDENNLKDPGGSEFDSISK 20 1 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 381174900.0 164831300.0 192773600.0 23570000.0 True False 213377367.16067463 182045579.69838646 19280501.848622955 1.0 0.8531625547769782 0.09035870160542661 27.66883191737604 -7.079565263254404 0.7721763562507259 1.0004357569944369 4.248606421225488e-22 0.9965134486334848 0.023543883855789025 0.07800012199455433 0.07856873045553524 0.021643020105062718 0.05547882595112104 8.32596798768662e-08 7.079565263254404 -1.0004357569944369 down QSDENNLKDPGGSEFDSISK(ub)NTWAPAPDTWAPAPDQTEQDQNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QSDENNLKDPGGSEFDSISKNTWAPAPDTWAPAPDQTEQDQNR 43 2 Q5TH58;Q9H6K1-2;Q9H6K1 Q5TH58 C6orf106 Uncharacterized protein C6orf106 1 135895000.0 45153000.0 69931000.0 20811000.0 True False 68500402.12646826 57451266.67660318 16697696.728214677 1.0 0.8386996994635783 0.24376056504583293 26.029609121542492 -6.946739700078786 0.5935590234089889 1.0068075561278982 0.04553260575386178 0.998919959724236 0.010687770563879324 0.0848219360467195 0.041588419289415965 0.011040162820315188 0.04989507394335073 1.1304732751953788e-07 6.946739700078786 -0.9612749503740364 down QSEENNNLQSQVQK(ub)LTEENTTLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QSEENNNLQSQVQKLTEENTTLR 23 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7;B4DSP0;A0A087WZG9;Q86TG7-2 A0A087WUL4;B4DSP0 PEG10 Retrotransposon-derived protein PEG10 1 106246000.0 0.0 26587000.0 79659000.0 True False 0.0 21842342.12482087 63914363.73422003 0.0 QSEENNNLQSQVQK(ub)LTEENTTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QSEENNNLQSQVQKLTEENTTLR 23 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7;B4DSP0;A0A087WZG9;Q86TG7-2 A0A087WUL4;B4DSP0 PEG10 Retrotransposon-derived protein PEG10 1 10440600.0 5154600.0 5286000.0 0.0 True False 4286278.287498308 5257523.268811152 0.0 1.0 1.2265940091070737 0.0 22.03129408965134 -6.906129824546211 1.2862035280895279 1.1182566977303554 1.0330857316320024e-22 0.9509990564425115 0.11796441037266751 0.13055806183550295 0.43316106176515357 0.07506600239350687 0.1486565534521485 1.2412811933760596e-07 6.906129824546211 -1.1182566977303554 down QSEENNNLQSQVQK(ub)LTEENTTLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QSEENNNLQSQVQKLTEENTTLR 23 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7;B4DSP0;A0A087WZG9;Q86TG7-2 A0A087WUL4;B4DSP0 PEG10 Retrotransposon-derived protein PEG10 1 139086000.0 0.0 25096000.0 113990000.0 True False 0.0 23699385.538843006 93244989.63617028 0.0 QSFTMVADTPENLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QSFTMVADTPENLR 14 0 Q14847;Q14847-2;C9J9W2;F6S2S5 Q14847 LASP1 LIM and SH3 domain protein 1 0 14378300.0 4474700.0 4120400.0 5783200.0 False True 5866375.033056436 3505652.3811934027 5184809.940371597 1.0 0.5975840892270614 0.8838183565073341 22.484037873803903 -10.050038687078407 6.007455360138009 1.0000005092725723 0.7407012228671834 0.5224905230490531 0.11685465028939894 7.970228197035338e-07 1.2601122945018288e-07 0.1131442511680234 0.037714676208136975 8.911715487777511e-11 10.050038687078407 -0.2592992864053889 QSFTMVADTPENLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QSFTMVADTPENLR 14 0 Q14847;Q14847-2;C9J9W2;F6S2S5 Q14847 LASP1 LIM and SH3 domain protein 1 0 13261100.0 3926700.0 0.0 9334400.0 False True 3802049.0578669137 0.0 6889440.614002485 1.0 0.0 1.8120335927142688 21.858345716535442 -6.756902009834129 1.6242927792272712 0.4169118475679398 1.8176240098169636 0.6781453579024851 0.4204341432094793 0.2881457683790176 1.4976118781427412 0.20430709803495456 0.4924643429983776 1.7502415522945013e-07 6.756902009834129 1.4007121622490237 QSFTMVADTPENLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QSFTMVADTPENLR 14 0 Q14847;Q14847-2;C9J9W2;F6S2S5 Q14847 LASP1 LIM and SH3 domain protein 1 0 15331800.0 4474700.0 5917900.0 4939200.0 False True 6129117.5142206475 5656427.610121687 3772662.6860170783 1.0 0.9228779831676851 0.6155311392323327 22.547247935326794 -6.944960562293102 0.611683132448991 1.0033917878096448 0.5189655912552462 0.9987440103566125 0.005885662691122671 0.08557487520547417 0.04484072521134102 0.005973143541150373 0.025931661332966885 1.1351138891816518e-07 6.944960562293102 -0.48442619655439856 QSGDGQESTEPVENK(ub)VGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QSGDGQESTEPVENKVGK 18 1 O15234;J3KSY7 O15234 CASC3 Protein CASC3 1 8741400.0 2205200.0 4848300.0 1687900.0 True False 2891038.555187175 4124952.538525383 1513252.2994800843 1.0 1.426806477943467 0.5234286124496571 21.463156418196707 -6.778252871466599 1.5428464653421927 1.2422227627547706 0.5166836360781414 0.761077747996636 0.18036059671461854 0.2533124466630098 1.1909043201565024 0.09208815188751446 0.21759361466008828 1.6662767269717625e-07 6.778252871466599 -0.7255391266766292 QSGDGQESTEPVENK(ub)VGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QSGDGQESTEPVENKVGK 18 1 O15234;J3KSY7 O15234 CASC3 Protein CASC3 1 12885630.0 3368400.0 8605400.0 911830.0 True False 2800973.8454214255 8559041.002161842 1102489.4371744285 1.0 3.0557375664727338 0.39360932947538874 21.417497081384585 -6.700473711011831 1.8290660850096745 2.2759101924923772 0.4014138667842556 0.41992275216604047 0.867672777799844 0.39451233918113626 2.5662504755095665 0.378395045722241 0.9726048129276081 1.9930871493247435e-07 6.700473711011831 -1.8744963257081215 QSGEAFVELGSEDDVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QSGEAFVELGSEDDVK 16 0 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 19254300.0 3649800.0 8151200.0 7453300.0 False True 4784923.144713473 6935072.733128749 6682104.013102019 1.0 1.4493592735738767 1.3964913982964615 22.190064321698756 -10.500426197245428 6.071487664767555 0.9996081611255115 1.422925335935169 0.9884160311045765 0.021583219702461576 0.00011458026052366266 9.427878472043086e-06 0.020916593625569045 0.0069659542054307695 3.1591758640655357e-11 10.500426197245428 0.42331717480965747 QSGEAFVELGSEDDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QSGEAFVELGSEDDVK 16 0 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 24430600.0 6877400.0 2992200.0 14561000.0 False True 6659080.701498427 4187001.0641168677 10747037.279363459 1.0 0.6287656287413228 1.6138920312146328 22.666891593627927 -6.804618868038128 1.4370160589028202 0.7963575384461379 1.6290871827224414 0.8453131343965435 0.1597684336414989 0.21423184229805503 0.8728498201957418 0.08744718547127048 0.20282201779390102 1.5681266367613668e-07 6.804618868038128 0.8327296442763035 QSGEAFVELGSEDDVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QSGEAFVELGSEDDVK 16 0 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 25493800.0 3649800.0 10013000.0 11831000.0 False True 4999229.692136347 9570592.551436909 9036761.46709347 1.0 1.9144134478340116 1.8076307798595552 22.253274383221648 -10.030844188542774 4.6078312245167075 0.9999725715008276 1.861022113867068 0.9885961080309862 0.0435938418218272 15187774.322269045 14799923.507362282 5172.795028730376 0.015953712187009778 9.314419881694516e-11 10.030844188542774 0.8610495423662403 QSGEAFVELGSEDDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QSGEAFVELGSEDDVK 16 0 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 12699000.0 6877400.0 2816700.0 3004900.0 False True 5718862.820478954 2801525.8780288254 3633210.6969121895 1.0 0.4898746422097598 0.6353029983341878 22.447296869062203 -10.603383703067069 9.808923998755313 1.0000563003073377 0.5625888202719944 0.9234422045310883 0.05937087777276759 7.310766326324248e-05 2.956052393893436e-06 0.05749291116306136 0.01916186840530374 2.492391703483014e-11 10.603383703067069 -0.4374674800353433 QSHLLLQSSIPDQQLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QSHLLLQSSIPDQQLLK 17 0 A0MZ66-2;A0MZ66-8;A0MZ66-4;A0MZ66-5;A0MZ66-6;A0MZ66;A0MZ66-3 A0MZ66-2 KIAA1598 Shootin-1 0 5519400.0 1815800.0 1907700.0 1795900.0 False True 2380531.3842322137 1623078.596156357 1610077.4954892371 1.0 0.681813567721496 0.6763521397591366 21.1828522184149 QSIWTSTISSHLATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QSIWTSTISSHLATK 15 0 P09417;P09417-2;H0Y8F7;B7Z415;D6RGG7 P09417 QDPR Dihydropteridine reductase 0 36479000.0 10576000.0 11343000.0 14560000.0 False True 13865238.418129679 9650668.6146677 13053470.869382089 1.0 0.6960333694694235 0.9414530407435221 23.72496908850065 -9.93852640795741 6.1415316989320745 1.0000000548556243 0.8187432059254668 0.4210589661864793 0.10019216124394593 7.519834844207834e-08 1.3181082659319342e-08 0.09701067189091418 0.03233688099318076 1.1520560051228903e-10 9.93852640795741 -0.18125684893015748 QSIWTSTISSHLATK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QSIWTSTISSHLATK 15 0 P09417;P09417-2;H0Y8F7;B7Z415;D6RGG7 P09417 QDPR Dihydropteridine reductase 0 39051100.0 12646000.0 5785100.0 20620000.0 False True 12244559.652070422 8095120.598897953 15219003.41325969 1.0 0.6611197812678511 1.2429196186476434 23.545637555777986 -6.748806582834118 1.6542270367392518 0.800449675640485 1.2439737756846578 0.6438310638631164 0.14239221090596055 0.302132841889431 1.6263056840988497 0.0680081149543816 0.16531495479101174 1.7831727435235367e-07 6.748806582834118 0.44352410004417286 QSIWTSTISSHLATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QSIWTSTISSHLATK 15 0 P09417;P09417-2;H0Y8F7;B7Z415;D6RGG7 P09417 QDPR Dihydropteridine reductase 0 18536600.0 10576000.0 7960600.0 0.0 False True 14486233.005653469 7608874.369816111 0.0 1.0 0.5252486527620144 0.0 23.78817915002354 -7.852776748723607 0.6088768024204588 1.0068657129315706 7.007437123409792e-18 0.9884252512291246 0.04394046545088772 0.11483997542838195 0.15815403325043811 0.043874499953384244 0.07760737270106062 1.4035350134268005e-08 7.852776748723607 -1.0068657129315706 down QSIWTSTISSHLATK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QSIWTSTISSHLATK 15 0 P09417;P09417-2;H0Y8F7;B7Z415;D6RGG7 P09417 QDPR Dihydropteridine reductase 0 23830700.0 12646000.0 7032000.0 4152700.0 False True 10515709.312789261 6994117.220257288 5021010.370084604 1.0 0.6651113122489042 0.4774770983806128 23.326042831212263 -10.88551945755971 0.10086882536865456 1.973347495607268 4.032691954323928e-14 0.9998954288049562 0.002210080274872675 3.0914421505139997 0.05940976968336045 1.0075258969328718 0.30272825590881786 1.3016089986924194e-11 10.88551945755971 -1.9733474956072277 QSK(ub)LQVLDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QSKLQVLDLR 10 1 Q5VWM4;Q5VXH5 Q5VWM4 PRAMEF8;PRAMEF7 PRAME family member 8;PRAME family member 7 1 13956800.0 2267900.0 3249300.0 8439600.0 True False 2195906.755885697 4546762.434875652 6229015.57742709 1.0 2.070562615051367 2.8366484873419315 21.066385364251367 -7.834049949375153 0.16177663707534207 1.979417356445253e-23 4.259573226998641 0.9999489109989055 0.005383863856854237 0.12831914786560444 0.023738138751625226 0.23246219068583304 0.325064834875271 1.4653792940540378e-08 7.834049949375153 4.259573226998641 QSK(ub)LQVLDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QSKLQVLDLR 10 1 Q5VWM4;Q5VXH5 Q5VWM4 PRAMEF8;PRAMEF7 PRAME family member 8;PRAME family member 7 1 13470200.0 2267900.0 3423900.0 7778400.0 True False 1885859.3350051225 3405454.7711090646 9404827.476741914 1.0 1.8057840836256298 4.98702490804616 20.846790639685643 -6.945175305761349 0.6095167841757176 0.9647872521275354 5.993553505071186 0.998766190650747 0.06046183058930065 0.08548290732106492 0.04443992545486752 0.06148620117356102 0.26820492629402615 1.1345527537113229e-07 6.945175305761349 5.028766252943651 QSK(ub)LQVLDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QSKLQVLDLR 10 1 Q5VWM4;Q5VXH5 Q5VWM4 PRAMEF8;PRAMEF7 PRAME family member 8;PRAME family member 7 1 12156500.0 1642100.0 2573600.0 7940800.0 True False 2125730.8206302105 2430376.8976237797 6495655.879488555 1.0 1.1433135719899152 3.0557283247945772 21.019527490591745 -6.921919089011702 0.8103648942273636 0.9606511151171703 3.3781606832052926 0.9946976333300737 0.06823921284646105 0.09705577144563242 0.09985888922982047 0.05940057631780684 0.18133304895375535 1.1969635101467145e-07 6.921919089011702 2.4175095680881222 up QSKPVTTPEEIAQVATISANGDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QSKPVTTPEEIAQVATISANGDK 23 1 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 41431500.0 3825500.0 17354000.0 20252000.0 False True 5015267.5461947 14764850.84536217 18156517.31090149 1.0 2.9439806968154474 3.6202489984163706 22.25789523472247 -9.534777897416062 0.3084903282934502 1.444431495851947e-16 3.8642960986178916 0.9986770610474512 0.040397203290551666 0.9085747021982096 0.12539292335183827 1.1559003564642254 0.22953724454585345 2.9189193972163053e-10 9.534777897416062 3.8642960986178916 QSKPVTTPEEIAQVATISANGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QSKPVTTPEEIAQVATISANGDK 23 1 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 46239700.0 12536000.0 6127700.0 27576000.0 False True 12138051.54185947 8574522.565533362 20353018.337732762 1.0 0.7064167206707874 1.6767945223780796 23.53303351607657 -6.8255520870980115 1.3475709098470725 0.8425779944227418 1.700627953190821 0.8966889947509322 0.130600001851665 0.18637411015665975 0.6634379551579261 0.07612398392641097 0.17525874940576644 1.494334808609937e-07 6.8255520870980115 0.8580499587680792 QSKPVTTPEEIAQVATISANGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QSKPVTTPEEIAQVATISANGDK 23 1 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 47871500.0 3825500.0 16176000.0 27870000.0 False True 5239890.730250321 15461290.833121277 21287680.000667315 1.0 2.9506895523339773 4.062619069090847 22.32110529624536 -8.655582402259139 0.2493947874030671 4.05600675239368e-16 4.90095921845866 0.9992675716021648 0.034258016575732964 0.24379506553450958 0.07266754422001824 0.6435679199091471 0.4441423927552775 2.2101288706103537e-09 8.655582402259139 4.90095921845866 QSKPVTTPEEIAQVATISANGDKEIGNIISDAMKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QSKPVTTPEEIAQVATISANGDKEIGNIISDAMKK 35 3 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 10206800.0 5044200.0 2367700.0 2794900.0 True False 4194475.7959490465 2354944.730148344 3379300.6678424836 1.0 0.5614395802266184 0.8056550644793694 22.0000590906353 -10.129813492878233 5.324054961219122 1.000007368650945 0.6835473223528252 0.6912410135421354 0.09970055395158162 8.72047170848772e-06 1.4252908032077765e-06 0.09653689383679867 0.032178215421758735 7.416286642538972e-11 10.129813492878233 -0.31646004629811975 QSLDLSSEWWDDK(ub)LHAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QSLDLSSEWWDDKLHAR 17 1 E9PJF5;H0YCF7;G5E9I4;Q9HCU9 E9PJF5 BRMS1 Breast cancer metastasis-suppressor 1 1 11336300.0 3174200.0 2610100.0 5552000.0 True False 3073436.7584692333 3652326.541491691 4097764.6435702117 1.0 1.1883525930466132 1.3332841914766318 21.551421368635094 -6.974044595729072 0.12906764523921058 0.7723975109575629 1.7529876768106751 0.9999992426868289 0.00011860090015157456 0.07501076767230115 0.003871741316909455 0.009212845978915479 0.019894647986091397 1.061586542098249e-07 6.974044595729072 0.9805901658531122 QSLDLSSEWWDDK(ub)LHAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QSLDLSSEWWDDKLHAR 17 1 E9PJF5;H0YCF7;G5E9I4;Q9HCU9 E9PJF5 BRMS1 Breast cancer metastasis-suppressor 1 1 11308900.0 3174200.0 3263900.0 4870800.0 True False 2639487.94090271 3246316.722866577 5889261.759965355 1.0 1.2299039796924893 2.231213739870778 21.33182664406937 -6.9429254744933715 0.6317719486126817 0.9890759042995257 2.5261700800662394 0.998522408683931 0.020546492895939315 0.08645721101668705 0.048721774396732684 0.020475169094382403 0.08513254192835269 1.1404454727199758e-07 6.9429254744933715 1.5370941757667138 up QSLETICLLLAYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QSLETICLLLAYK 13 0 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62140;E7ETD8;C9J9S3;C9JP48;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 0 104440000.0 21755000.0 43961000.0 38724000.0 False True 33003925.50353944 36115816.08113926 31070184.42666786 1.0 1.094288498417138 0.9414087552505171 24.976134293763774 -6.739888966957736 1.6874944586743459 1.0561093230482557 0.941328064036357 0.6042986189015451 0.03961585947806899 0.31800609002286895 1.7781159130768531 0.018573852195480942 0.04557722656940268 1.8201661483176074e-07 6.739888966957736 -0.11478125901189862 QSLETICLLLAYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QSLETICLLLAYK 13 0 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62140;E7ETD8;C9J9S3;C9JP48;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 0 60212000.0 21755000.0 16960000.0 21497000.0 False True 28162276.355161157 16016161.090961799 17584766.57784676 1.0 0.568709748067883 0.6244085654185441 24.747260615856224 -10.162705139179492 5.272647897496852 1.000015524544818 0.5965591567434148 0.9859061677837591 0.022738946964917284 4.14990814752315e-06 6.58924554935423e-07 0.022017737368952975 0.007338963575357651 6.87535078116429e-11 10.162705139179492 -0.40345636780140315 QSLGELIGTLNAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QSLGELIGTLNAAK 14 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 75394000.0 10003000.0 38773000.0 26618000.0 False True 13114029.869189806 32988219.53597028 23863824.697885472 1.0 2.5154906512355164 1.8197171224957562 23.64460775014638 -10.094927315677216 4.583960574278003 0.9999180923379387 2.1676038869015732 0.789688960475214 0.2840483537774785 98811448.0323815 14.17569238950354 86445.33527810485 0.09723730672346909 8.03660613048422e-11 10.094927315677216 1.1676857945636345 QSLGELIGTLNAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QSLGELIGTLNAAK 14 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 97031000.0 32440000.0 22890000.0 41701000.0 False True 31410209.956758264 32030096.369773064 30778257.096815795 1.0 1.0197351884584083 0.9798806547039175 24.904730250708628 -6.772081939696396 1.5666805325125588 1.0112895378645272 0.9796396898021972 0.7383904132408987 0.00832215083274496 0.2630766783554972 1.2746610414175203 0.004186469637461787 0.009945828092193793 1.6901220209585726e-07 6.772081939696396 -0.031649848062330066 QSLGELIGTLNAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QSLGELIGTLNAAK 14 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 73112300.0 5628500.0 61023000.0 6460800.0 False True 8538845.998468034 50132968.87512481 5183820.048130757 1.0 5.871164427150839 0.6070867244895614 23.02560967608051 -6.663637694454275 1.9603934332024797 4.126265493126197 0.6291730977697119 0.2508841877582939 2.0722836386899948 0.4759723183436912 3.5202705342541973 0.8529854792235948 2.2976500917960734 2.1695132434026373e-07 6.663637694454275 -3.4970923953564848 QSLGELIGTLNAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QSLGELIGTLNAAK 14 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 127813000.0 10003000.0 50575000.0 67235000.0 False True 13701379.42091073 48340429.270840146 51355477.74829085 1.0 3.5281432464430624 3.748197620884311 23.707817811669273 -10.183789986369437 0.5340965194185913 1.547758323663284e-21 3.7342669489265217 0.9995057175317223 0.027721347956015847 1.486394641705556 0.25074289632498326 2.315283310321407 0.04200871982638147 6.54952815821215e-11 10.183789986369437 3.7342669489265217 QSLGELIGTLNAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QSLGELIGTLNAAK 14 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 52125000.0 32440000.0 9699800.0 9985200.0 False True 26975297.3356701 9647545.252140447 12073059.15365155 1.0 0.35764370387062466 0.44755981754043717 24.685135526142904 -10.737875305776686 6.965461413643183 1.008921635895579 0.4026017607055309 0.983293267516231 0.03670809969085534 0.005058090402057704 0.00019034620937941255 0.035348905652447374 0.011847488231133692 1.828625173917078e-11 10.737875305776686 -0.6063198751900482 QSLGELIGTLNAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QSLGELIGTLNAAK 14 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 21208400.0 5628500.0 8064000.0 7515900.0 False True 7286204.204321989 7615231.311174291 6148083.319646391 1.0 1.0451575467315521 0.8437978331707346 22.79673599817296 -6.847815542018598 1.2455483411217685 1.0240601016572397 0.8360793616500996 0.9370742954098072 0.02164105816956166 0.15987313849858056 0.4783804589969269 0.013602940815615264 0.031437941617638306 1.4196603662857123e-07 6.847815542018598 -0.18798074000714016 QSLVLPHSTK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QSLVLPHSTKER 12 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 29591500.0 8996400.0 9675100.0 10920000.0 True False 11646017.145556051 9136672.17990358 8932672.04866197 1.0 0.7845319189994495 0.7670151895723892 23.473333312069986 -13.99999999999929 0.35565873295397366 3.74416674765571 0.7647733209051437 0.999765338063509 0.0016228964036556805 21.236408406109344 0.1923971166125987 44.14500811299227 0.005127563226824355 1.0000000000016361e-14 13.99999999999929 -2.9793934267505664 QSMWSLLTALSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QSMWSLLTALSGK 13 0 E9PHA2;Q15003;Q15003-2;H7C415 E9PHA2 NCAPH Condensin complex subunit 2 0 8735600.0 3153000.0 1740600.0 3842000.0 False True 4133613.533695431 1480909.264805658 3444466.695066346 1.0 0.3582602129429676 0.8332822280042733 21.978972081676293 -9.880601537298496 6.398643081658081 1.0000000277968766 0.5957712204736882 0.4912313436013783 0.1939269255816303 7.6741418238657e-08 1.3555568064016441e-08 0.18776894948151623 0.0625896460965491 1.3164320971928887e-10 9.880601537298496 -0.40422880732318833 QSMWSLLTALSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QSMWSLLTALSGK 13 0 E9PHA2;Q15003;Q15003-2;H7C415 E9PHA2 NCAPH Condensin complex subunit 2 0 7434300.0 3153000.0 1801500.0 2479800.0 False True 4318749.30662116 1721903.7732361518 1894122.313084135 1.0 0.3987042662087996 0.43858121382044996 22.042182143199184 -9.989268309472525 6.067414975901586 1.00000042846441 0.41864274266198515 0.9964836740900405 0.016279695691575568 9.43600471842384e-08 1.5717193517674595e-08 0.01576275908231274 0.005254249191203496 1.0250184686582224e-10 9.989268309472525 -0.5813576858024248 QSNPEFCPEK(ub)VALAEA ddPTM_RPMI8226_Bortezomib_1h_R1 1 QSNPEFCPEKVALAEA 16 1 Q9NWD8 Q9NWD8 TMEM248 Transmembrane protein 248 1 16751400.0 4949100.0 6423400.0 5378900.0 True False 6488318.027152572 5465053.758217087 4822343.0260521425 1.0 0.8422912895679145 0.7432346882306646 22.62941310480895 QSNPEFCPEK(ub)VALAEA ddPTM_RPMI8226_Bortezomib_2h_R1 1 QSNPEFCPEKVALAEA 16 1 Q9NWD8 Q9NWD8 TMEM248 Transmembrane protein 248 1 5279100.0 2746900.0 2532200.0 0.0 True False 2659701.1630770396 3543320.665248552 0.0 1.0 1.3322251065037858 0.0 21.34283272679266 -6.874201542625621 1.3523733161776204 1.1739428424844396 2.879302188985757e-20 0.9245581694204614 0.15551511619365257 0.15344545062828766 0.5642308871132349 0.09311947001180013 0.19104211633292734 1.3359753878434456e-07 6.874201542625621 -1.1739428424844396 down QSNPEFCPEK(ub)VALAEA ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QSNPEFCPEKVALAEA 16 1 Q9NWD8 Q9NWD8 TMEM248 Transmembrane protein 248 1 15814200.0 4949100.0 5651400.0 5213700.0 True False 6778916.014398599 5401702.461319341 3982331.43952204 1.0 0.7968386759543827 0.5874584418900398 22.692623166331842 -6.970747489905946 0.23966300962062226 1.0754974105987096 0.30274623755462615 0.9999876384546914 0.0005921398200653065 0.07606091534351633 0.00815742769547327 0.0050169384572459775 0.02042469844830312 1.0696766362370963e-07 6.970747489905946 -0.7727511730440835 QSNPEFCPEK(ub)VALAEA ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QSNPEFCPEKVALAEA 16 1 Q9NWD8 Q9NWD8 TMEM248 Transmembrane protein 248 1 7780300.0 2746900.0 2293400.0 2740000.0 True False 2284169.058303086 2281044.998995744 3312921.3316714005 1.0 0.9986322994368627 1.4503835955700128 21.123238002226937 -6.906216913329144 0.9211109694145734 0.9842847575410251 1.5042767817486782 0.9894138385400567 0.021877916822138275 0.10697349238671554 0.15273050110069586 0.017583194860977897 0.04735497533653165 1.2410323050413948e-07 6.906216913329144 0.5199920242076531 QSSFALLGDLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QSSFALLGDLTK 12 0 Q92973-2;Q92973;Q92973-3;O14787-2;O14787;A0A075B780 Q92973-2;O14787-2 TNPO1;TNPO2 Transportin-1;Transportin-2 0 20369200.0 5216100.0 5510500.0 9642600.0 False True 6838357.61278426 4688354.879760763 8644876.250350527 1.0 0.6855966220596473 1.2641743441713247 22.705218439989597 -6.759119034551015 1.6157848314527714 0.8171844889933862 1.2661994365704148 0.6874312080327646 0.13222200415060764 0.2843638835503786 1.463010063913262 0.064572440722821 0.15531312662400856 1.7413295318724328e-07 6.759119034551015 0.44901494757702853 QSSGASSSSFSSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QSSGASSSSFSSSR 14 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 0 7852720.0 529020.0 3966400.0 3357300.0 False True 693550.343036967 3374628.5809061048 3009918.801495638 1.0 4.865729812963604 4.339870683814522 19.40364108231188 -10.205219222851822 4.941413570817525 0.9995741078199225 4.602800248394453 0.9842733772200867 0.21468109051858023 0.0010073656845764186 0.0001620242851506524 0.20788363605321183 0.06928802402434538 6.234200665181939e-11 10.205219222851822 3.60322614057453 QSSGASSSSFSSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QSSGASSSSFSSSR 14 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 0 5782450.0 1901300.0 785050.0 3096100.0 False True 1840944.272219001 1098524.5589816677 2285138.5289909453 1.0 0.5967179862851306 1.2412860962035153 20.812014524414952 -6.7375818707506525 1.6959604967359394 0.7593737926644621 1.241437923403992 0.5938694094331218 0.1694535015132555 0.32220478974266614 1.818801846270231 0.07908112231539192 0.19454467163269773 1.8298611186785307e-07 6.7375818707506525 0.4820641307395299 QSSGASSSSFSSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QSSGASSSSFSSSR 14 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 0 8422320.0 529020.0 3950800.0 3942500.0 False True 724612.9902279498 3776240.592451506 3011362.6983362357 1.0 5.211389587790264 4.1558221270486975 19.46685114383477 -9.762527378420643 6.215380457550884 0.999999925026117 4.683605857424153 0.9419861787457315 0.43093361133371394 4.483596438600731e-07 8.803007582609357e-08 0.4172496749962668 0.1390832249989223 1.727717059816008e-10 9.762527378420643 3.683605932398036 QSSGPGASSGTSGDHGELVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QSSGPGASSGTSGDHGELVVR 21 0 P29692-3;E9PL71;E9PN91 P29692-3 EEF1D Elongation factor 1-delta 0 8657500.0 1064700.0 4368700.0 3224100.0 False True 1395832.0105694677 3716906.98905922 2890501.0597510114 1.0 2.662861261895553 2.070808691779287 20.4126938918877 -10.206189835178582 5.273032107110315 0.9999108936653331 2.3668349768377723 0.8766408565620563 0.24170444961600027 0.00025322382941597596 3.8119725511850404e-05 0.2340443013702717 0.07800977567206266 6.220283299050014e-11 10.206189835178582 1.3669240831724392 QSSGPGASSGTSGDHGELVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QSSGPGASSGTSGDHGELVVR 21 0 P29692-3;E9PL71;E9PN91 P29692-3 EEF1D Elongation factor 1-delta 0 8276500.0 1064700.0 3752600.0 3459200.0 False True 1458348.3624356342 3586797.7238112655 2642208.204460294 1.0 2.4594930924603227 1.811781240010074 20.47590395341059 -10.588857329541312 5.942677541496249 0.9959078548306523 2.1356371662351514 0.8038745195523929 0.26442725647599613 0.014342927863984748 0.0009923106658328324 0.2561463744948386 0.08534353005123746 2.5771676455435603e-11 10.588857329541312 1.139729311404499 QSSQPAETDSMSLSEK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QSSQPAETDSMSLSEKSR 18 1 C9J0I9;Q86WB0-3;Q86WB0-2;Q86WB0 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 1790670.0 719770.0 1070900.0 0.0 True False 696921.2953321794 1498515.9546697242 0.0 1.0 2.1501939526119287 0.0 19.41063621339242 -6.765497329274049 1.6185873956627455 1.6667406167363474 1.2186245120538404e-09 0.6964584284566626 0.4840207521594179 0.2775121158218547 1.4384759792326964 0.23688464619792796 0.5601946940223178 1.715942262402064e-07 6.765497329274049 -1.666740615517723 QSSQPAETDSMSLSEK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QSSQPAETDSMSLSEKSR 18 1 C9J0I9;Q86WB0-3;Q86WB0-2;Q86WB0 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 3983370.0 719770.0 2131300.0 1132300.0 True False 598520.6462174868 2119818.2638700744 1369058.6948363248 1.0 3.5417629738703913 2.287404291712344 19.191041488826695 -8.978711273184 10.857818975165697 1.0000013949190458 2.9145836326145886 0.7564719933917744 0.5120897876386243 158442581.96786907 0.0 0.49582880481320596 0.17530195509551946 1.0502404154076102e-09 8.978711273184 1.9145822376955428 QSSQPAETDSMSLSEK(ub)SR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QSSQPAETDSMSLSEKSR 18 1 C9J0I9;Q86WB0-3;Q86WB0-2;Q86WB0 C9J0I9 ZC3HC1 Nuclear-interacting partner of ALK 1 10194400.0 1919700.0 2467300.0 5807400.0 True False 2485089.4929442867 2329992.586068989 4750512.788956002 1.0 0.9375890054198643 1.9116063234115908 21.244866376323856 -6.89161499201635 1.0128103529776311 0.9496729163243753 1.9980707386183982 0.9819109534487402 0.05987411155882687 0.11784141613265589 0.21428659524096308 0.04494699432398103 0.1127217953994791 1.2834678902583242e-07 6.89161499201635 1.048397822294023 QSTQVMAASMSAFDPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QSTQVMAASMSAFDPLK 17 0 Q92734-2;Q92734;Q92734-4;Q92734-3;C9JJP5 Q92734-2 TFG Protein TFG 0 7622500.0 2377100.0 2691100.0 2554300.0 False True 3116401.119869147 2289598.3698256398 2290005.5385757326 1.0 0.7346930904458719 0.734823743957545 21.571449507602402 -10.150411929619276 5.069063464541598 1.0000130925803576 0.7347584172042324 0.9999998158893658 5.3339074145141055e-05 14896.670449172723 29829.44325430456 1.5124903829080756 1.8259386121485685e-05 7.072746140371741e-11 10.150411929619276 -0.26525467537612524 QSTQVMAASMSAFDPLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QSTQVMAASMSAFDPLK 17 0 Q92734-2;Q92734;Q92734-4;Q92734-3;C9JJP5 Q92734-2 TFG Protein TFG 0 6379500.0 2130900.0 1186500.0 3062100.0 False True 2063255.7458956891 1660275.637515762 2260044.148969081 1.0 0.8046872719576565 1.095377610586982 20.97649122742085 -6.725668691819625 1.7388796189841775 0.8818988540183018 1.0950767959054755 0.5391258024978087 0.08213660001342718 0.34442473708835286 2.0381585658935726 0.037462560416451136 0.09342519900865619 1.8807510293338017e-07 6.725668691819625 0.21317794188717365 QSTQVMAASMSAFDPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QSTQVMAASMSAFDPLK 17 0 Q92734-2;Q92734;Q92734-4;Q92734-3;C9JJP5 Q92734-2 TFG Protein TFG 0 7287900.0 2377100.0 2382800.0 2528000.0 False True 3255978.1087120743 2277520.017134112 1930938.4657942934 1.0 0.699488737666913 0.5930440566008873 21.634659569125294 -13.999999999999998 0.144595559023883 2.442378207755717 0.4683314621115101 0.999585264336256 0.0035093219832513854 11.941502120724136 0.11945231519697859 4.848824830299962 0.11187120276987418 1.0000000000000041e-14 13.999999999999998 -1.9740467456442068 QSVAQPLGPENLHGEQK(ub)IEAETR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QSVAQPLGPENLHGEQKIEAETR 23 1 Q9Y2K6 Q9Y2K6 USP20 Ubiquitin carboxyl-terminal hydrolase 20 1 15256300.0 2920200.0 7074200.0 5261900.0 True False 3828410.4792570253 6018756.935015622 4717449.063708899 1.0 1.5721294692996646 1.2322213329184095 21.868314092105255 -10.312894505780392 5.185570164536163 0.999890002768931 1.4021754011090848 0.6511522515350352 0.1387669155925716 0.00017651585065751378 2.3389116423172947e-05 0.13439700201137803 0.044786829424526046 4.8652537293383475e-11 10.312894505780392 0.40228539834015375 QSVAQPLGPENLHGEQK(ub)IEAETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QSVAQPLGPENLHGEQKIEAETR 23 1 Q9Y2K6 Q9Y2K6 USP20 Ubiquitin carboxyl-terminal hydrolase 20 1 14294200.0 3925200.0 3952900.0 6416100.0 True False 3800596.6745458483 5531313.584101176 4735530.931125872 1.0 1.4553803146612865 1.2459967043705693 21.857794501520562 -10.112490112427631 4.339256425925461 0.9999545253340697 1.3506885095123862 0.7890390550033469 0.085480501080037 12633852.958114736 14721386.370950462 4750.3012669551945 0.029262249088443413 7.718090871445229e-11 10.112490112427631 0.35073398417831647 QSVAQPLGPENLHGEQK(ub)IEAETR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QSVAQPLGPENLHGEQKIEAETR 23 1 Q9Y2K6 Q9Y2K6 USP20 Ubiquitin carboxyl-terminal hydrolase 20 1 23826900.0 12227000.0 4625500.0 6974400.0 True False 18549252.91343494 3800043.385803544 5595906.78301189 1.0 0.20486234154752564 0.3016782837091439 24.144857746486874 -10.652998024098299 6.687150509204736 1.0035703350781437 0.2532703128247058 0.9875494923461741 0.0395249428771289 0.0021075659711221233 0.00010936331915117533 0.03833671379651146 0.01275662046024331 2.2233200060269652e-11 10.652998024098299 -0.750300022253438 QSVAQPLGPENLHGEQK(ub)IEAETR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QSVAQPLGPENLHGEQKIEAETR 23 1 Q9Y2K6 Q9Y2K6 USP20 Ubiquitin carboxyl-terminal hydrolase 20 1 18091800.0 2920200.0 3560600.0 11611000.0 True False 3999876.8554377146 3403280.9186703563 8868720.936051251 1.0 0.8508464239452013 2.2172484945366473 21.931524153628146 -6.879845299784735 1.080624631036221 0.9077375066980706 2.313812072581758 0.9735620335092707 0.0995111722525541 0.1277689205734203 0.2730944684616565 0.07094447935952161 0.17149999524615808 1.318726398973141e-07 6.879845299784735 1.4060745658836873 up QSVAQPLGPENLHGEQK(ub)IEAETR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QSVAQPLGPENLHGEQKIEAETR 23 1 Q9Y2K6 Q9Y2K6 USP20 Ubiquitin carboxyl-terminal hydrolase 20 1 14248100.0 3925200.0 6020700.0 4302200.0 True False 3263977.715843776 5988265.294084614 5201770.128874714 1.0 1.8346526279933804 1.593690454326523 21.63819977695484 -10.104948481119402 4.503284872167508 0.9999375843343726 1.7141715410539757 0.9213366766832854 0.09837239559160203 15165102.755810445 17014540.964765158 8130.991551133155 0.0336754868002496 7.853287899739295e-11 10.104948481119402 0.7142339567196031 QSVAQPLGPENLHGEQK(ub)IEAETR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QSVAQPLGPENLHGEQKIEAETR 23 1 Q9Y2K6 Q9Y2K6 USP20 Ubiquitin carboxyl-terminal hydrolase 20 1 26351700.0 12227000.0 5322500.0 8802200.0 True False 15828092.530202517 5026298.196146477 7200289.918198947 1.0 0.3175555226604533 0.45490572565580145 23.915984068579323 -9.887839575775741 6.745743175072717 1.0000000193044116 0.3862306241640417 0.9638009801023005 0.05607298556776159 1.6200306706837746e-08 2.638471069299206e-09 0.05429243643703263 0.01809747827299896 1.2946739933118352e-10 9.887839575775741 -0.61376939514037 QSVDGK(ub)APLATGEDDDDEVPDLVENFDEASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QSVDGKAPLATGEDDDDEVPDLVENFDEASK 31 1 P20290;P20290-2 P20290;P20290-2 BTF3 Transcription factor BTF3 1 40139200.0 12347000.0 23182000.0 4610200.0 True False 11955051.24340609 32438693.49253297 3402650.3169645853 1.0 2.7133880760590467 0.28462030381018616 23.511116978154796 -6.717154937700332 1.7695170281795332 2.0455621552967784 0.28899062120192665 0.49905818745997854 0.7212637356800493 0.36088306957394745 2.2067901493644744 0.323838351688957 0.8156993515518925 1.917984363793028e-07 6.717154937700332 -1.7565715340948518 QSVQIPVFVMIRPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QSVQIPVFVMIRPR 14 1 Q5TCZ7;A0A0B4J226;Q9NTM9 Q5TCZ7 CUTC Copper homeostasis protein cutC homolog 0 4120600.0 1218300.0 1607500.0 1294800.0 False True 1597203.0980339807 1367667.2659859222 1160826.5165986218 1.0 0.8562888887890354 0.7267870429424406 20.607116344751077 -6.972361757646414 0.19364181506604716 1.0836998668849378 0.4958247716333302 0.9999954177160831 0.00023880062898236611 0.07554358242663363 0.0062043398888716895 0.004433023303596583 0.013977716591281174 1.0657080403053814e-07 6.972361757646414 -0.5878750952516076 QSVQIPVFVMIRPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QSVQIPVFVMIRPR 14 1 Q5TCZ7;A0A0B4J226;Q9NTM9 Q5TCZ7 CUTC Copper homeostasis protein cutC homolog 0 5327500.0 1763100.0 1507100.0 2057300.0 False True 1707131.3555721461 2108892.8894226737 1518431.4123229464 1.0 1.2353430698458918 0.8894637236711308 20.703142640426528 -6.723472479327464 1.746545183452337 1.1426447576172807 0.8898846497557336 0.5289528942034532 0.098993556427007 0.3486254665988166 2.080077441236454 0.044969794334860126 0.1124442945799726 1.8902860123406244e-07 6.723472479327464 -0.2527601078615471 QSVQIPVFVMIRPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QSVQIPVFVMIRPR 14 1 Q5TCZ7;A0A0B4J226;Q9NTM9 Q5TCZ7 CUTC Copper homeostasis protein cutC homolog 0 7160200.0 1218300.0 2018800.0 3923100.0 False True 1668738.433319555 1929602.7407211468 2996544.578780696 1.0 1.1563242640026363 1.7956945911647693 20.67032640627397 -6.944364279635605 0.6176364271990972 0.9929895130926931 1.992764475992215 0.9986813848906708 0.012499423021346661 0.08583098321840728 0.045959696106546946 0.012615175383719618 0.05406218215647998 1.136673461364004e-07 6.944364279635605 0.9997749628995218 QSVQIPVFVMIRPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QSVQIPVFVMIRPR 14 1 Q5TCZ7;A0A0B4J226;Q9NTM9 Q5TCZ7 CUTC Copper homeostasis protein cutC homolog 0 9414700.0 2611400.0 4242900.0 2560400.0 False True 3380508.7783897007 4006778.885191149 2094433.471922537 1.0 1.185259127503219 0.6195616131250565 21.688808962820175 -6.818505636120765 1.3785064457303067 1.100004588210483 0.6076202314433631 0.8808763697354363 0.0812751091126435 0.1954283481507911 0.7301486458642313 0.046338247497690575 0.1068378133891147 1.5187782317351576e-07 6.818505636120765 -0.4923843567671199 QSVYEEK(ub)LK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QSVYEEKLK 9 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 224925000.0 23426000.0 100367000.0 101132000.0 True False 30711712.857706733 85392634.8275017 90667830.76664487 1.0 2.7804582317874025 2.952223185555503 24.87228564094759 -10.39969957673182 0.48182504358413963 6.823619668103064e-21 2.949371288189553 0.999494800691638 0.019837690233070693 1.7795552368128305 0.22696213115883257 2.30659279906879 0.03608926114093991 3.9838265651676624e-11 10.39969957673182 2.949371288189553 QSVYEEK(ub)LK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QSVYEEKLK 9 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 846521000.0 189070000.0 573220000.0 84231000.0 True False 286833012.86849964 470924412.4116978 67582705.93024129 1.0 1.641806874676577 0.23561690216329803 28.095635838789818 -6.782578495933332 1.5255268576768741 1.362183512388855 0.22350261343610087 0.7765178712390146 0.27173092633952245 0.24658064999428422 1.133558637320934 0.1402620125238013 0.3302947330210452 1.6497627903614815e-07 6.782578495933332 -1.1386808989527542 QSVYEEK(ub)LK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QSVYEEKLK 9 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 160691000.0 23426000.0 90511000.0 46754000.0 True False 32087225.263846327 86511924.7401485 35711668.12885536 1.0 2.6961485148304227 1.1129559454021352 24.935495702470483 -6.629833127340401 2.080535005546422 2.117542473112418 1.1192520003851452 0.11709167099320894 0.7275781818600512 0.559422800447014 4.614215614786119 0.28600731945681673 0.8062526015364928 2.3451297313521035e-07 6.629833127340401 -0.9982904727272728 QSVYEEK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QSVYEEKLK 9 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 262567000.0 100236000.0 126000000.0 36331000.0 True False 83350675.20771345 125321212.99095827 43927644.12443562 1.0 1.503541665123317 0.52702205488997 26.31269055046431 -6.766574004306381 1.5878073821116496 1.2900829520742643 0.5222563288068507 0.7171987795035304 0.21203955203072192 0.2720045034928036 1.3528612014852186 0.10530045061605543 0.25143051138346606 1.71169347720632e-07 6.766574004306381 -0.7678266232674136 QTAISQPASGNTFSHHSMVSMLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTAISQPASGNTFSHHSMVSMLGK 24 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 48789000.0 10441000.0 14602000.0 23746000.0 False True 13688252.110787835 12423438.518150212 21288991.707716122 1.0 0.9075986048181556 1.5552746643918163 23.706434901012535 -6.8707366552998765 1.1302543823056532 0.9475058425273691 1.5937302509654554 0.9654096980589333 0.053198419289935475 0.13614722669932564 0.3246242423978227 0.036513008877546695 0.086554311334463 1.346676695697114e-07 6.8707366552998765 0.6462244084380863 QTAISQPASGNTFSHHSMVSMLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTAISQPASGNTFSHHSMVSMLGK 24 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 24667800.0 6628600.0 3315200.0 14724000.0 False True 6418178.721312199 4638976.64853961 10867342.689468253 1.0 0.7227870786981092 1.6932128507706032 22.61373253294839 -6.830367502345824 1.3264201104734268 0.8519180169203943 1.719494350337735 0.9065790994580655 0.12474368487358402 0.18035924588928304 0.6204948847609489 0.07384092639886429 0.16991352714189592 1.4778572880472436e-07 6.830367502345824 0.8675763334173406 QTAISQPASGNTFSHHSMVSMLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTAISQPASGNTFSHHSMVSMLGK 24 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 36751000.0 10441000.0 14847000.0 11463000.0 False True 14301319.857415661 14191010.447536588 8755675.487895563 1.0 0.9922867671670266 0.6122284918587765 23.769644962535427 -6.9112880002428225 0.886921271215083 1.0112934078167914 0.5617353133971652 0.9913985416745948 0.016787284441146605 0.10357235898201106 0.1341940978102178 0.013832107567969772 0.0385321974547426 1.2266255307191054e-07 6.9112880002428225 -0.44955809441962624 QTAISQPASGNTFSHHSMVSMLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTAISQPASGNTFSHHSMVSMLGK 24 0 Q14157-4;Q14157-1;F8W726;Q14157-3;Q14157;Q14157-5 Q14157-4 UBAP2L Ubiquitin-associated protein 2-like 0 15779200.0 6628600.0 5080400.0 4070200.0 False True 5511974.596770122 5053030.876819557 4921260.0015215045 1.0 0.9167369675071626 0.8928306753092148 22.394137808382666 -13.999998723011705 0.17499611716177832 1.4256714362225247 0.8728263405881311 0.9995050202964112 0.0010219328615995392 12.14415492149342 0.13255606582440954 1.7559495014041426 0.01863850362741386 1.000002940378534e-14 13.999998723011705 -0.5528450956343935 QTASVTLQAIAAQNAAVQAVNAHSNILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTASVTLQAIAAQNAAVQAVNAHSNILK 28 0 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 0 16749000.0 8861700.0 3363800.0 4523500.0 False True 8580390.184149338 4706982.881985257 3338659.6479088343 1.0 0.5485744565183674 0.389103476212117 23.032611823568583 -13.999999999999998 0.14499185045160828 3.167767211599256 0.2031338702320153 0.9995838041447936 0.005278051888850483 11.942388893192186 0.11964032005821254 7.30663895923304 0.1668742049319106 1.0000000000000041e-14 13.999999999999998 -2.9646333413672408 QTASVTLQAIAAQNAAVQAVNAHSNILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTASVTLQAIAAQNAAVQAVNAHSNILK 28 0 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 0 17824900.0 8861700.0 3936600.0 5026600.0 False True 7368896.189873845 3915392.754446078 6077638.819627536 1.0 0.5313404685801537 0.8247692277140879 22.81301709900286 -10.461411968498544 6.081782709710222 1.0001706893842954 0.6780548481471216 0.6161348891057354 0.11979178928936139 0.00027739207463111564 2.4565019256573976e-05 0.11604872926695559 0.03866263374417372 3.456113779124498e-11 10.461411968498544 -0.32211584123717385 QTATQLLK(ub)LAHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTATQLLKLAHK 12 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 41950300.0 6990600.0 9343700.0 25616000.0 True False 9164744.297066698 7949656.381457331 22965502.04602278 1.0 0.8674171503073717 2.505853005999655 23.127663198425388 -6.887300545931134 1.0382589668493782 0.9061832117374147 2.6395202476840836 0.9791119920562941 0.10739643769520296 0.12135905808245971 0.2348806936922544 0.07908323789483464 0.19532679614993897 1.2962818912091456e-07 6.887300545931134 1.7333370359466689 up QTATQLLK(ub)LAHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTATQLLKLAHK 12 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 65999800.0 10627000.0 9614800.0 45758000.0 True False 10289651.701925697 13454039.780519633 33772607.08942464 1.0 1.3075311167239727 3.282191474285192 23.294690812973165 -6.934418072885684 0.7095988018380361 0.9743241881016053 3.7372924924953574 0.9973374115743274 0.0521768597657353 0.09040794131641805 0.06691382912957662 0.048853213257633185 0.17453667117456176 1.163005924577504e-07 6.934418072885684 2.7629683043937523 up QTATQLLK(ub)LAHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QTATQLLKLAHK 12 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 47717300.0 6058300.0 7829000.0 33830000.0 True False 9190884.021056911 6431853.781743812 27143485.67178429 1.0 0.6998079582995519 2.953305210858586 23.13177220248781 -6.873333945032798 1.1163735346751034 0.8262870063945544 3.093882178206565 0.9678956426018036 0.179015221644948 0.13369511292465833 0.3094063791116798 0.12418345648944777 0.2958199216566841 1.3386469565977203e-07 6.873333945032798 2.2675951718120104 up QTATQLLK(ub)LAHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTATQLLKLAHK 12 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 42752900.0 6990600.0 6105300.0 29657000.0 True False 9575213.733861687 5835547.658472766 22652627.405087557 1.0 0.6094430704806093 2.3657568420618165 23.19087325994828 -6.84837474980749 1.2430663793273957 0.791854874718959 2.4337339608102675 0.9378833256824726 0.18766048752777867 0.1592566872041366 0.4743961679270292 0.11818432505649386 0.2731910453547301 1.4178335545849304e-07 6.84837474980749 1.6418790860913086 up QTATQLLK(ub)LAHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTATQLLKLAHK 12 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 44556000.0 10627000.0 15371000.0 18558000.0 True False 8836821.355923729 15288193.372095378 22438391.997502875 1.0 1.7300557243750319 2.539192668239399 23.07509608840744 -6.969798960285744 0.2629434173089043 0.7808442476797669 3.512502745756664 0.9999807720184279 0.002756603120547736 0.07636799387464169 0.009263294829626323 0.016575214995826086 0.07601132563197237 1.0720154381872258e-07 6.969798960285744 2.731658498076897 QTATQLLK(ub)LAHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTATQLLKLAHK 12 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 43555300.0 6058300.0 11659000.0 25838000.0 True False 7842588.776946584 11010166.400915321 21135749.120268118 1.0 1.4038943917702127 2.6949964764692234 22.90289852458026 -6.950015568460697 0.5586756375289206 0.9829956190808857 3.1774586505509133 0.9992024837984265 0.02041456135893305 0.08347955881904465 0.03593693538366141 0.021918407530679904 0.10729488705033367 1.1219782332357449e-07 6.950015568460697 2.1944630314700273 up QTEATNAIAEMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTEATNAIAEMK 12 0 F5GXC2;S4R3G4;F8WBN2;F6SRV7;Q8NHM5-5;Q8NHM5-4;Q8NHM5-2;Q8NHM5-3;Q8NHM5 F5GXC2 KDM2B Lysine-specific demethylase 2B 0 953070000.0 203830000.0 429160000.0 320080000.0 False True 267223103.8925276 365131000.85257745 286961192.02416337 1.0 1.36639008953143 1.0738637035649958 27.993469506544884 -10.018745374783078 5.375439033988043 0.9999988305041279 1.2201268965485734 0.43020389713185136 0.11942339698763359 1.6737420917737462e-06 3.0547715551234753e-07 0.11563182029998242 0.03854373563986897 9.577554351157243e-11 10.018745374783078 0.22012806604444557 QTEATNAIAEMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTEATNAIAEMK 12 0 F5GXC2;S4R3G4;F8WBN2;F6SRV7;Q8NHM5-5;Q8NHM5-4;Q8NHM5-2;Q8NHM5-3;Q8NHM5 F5GXC2 KDM2B Lysine-specific demethylase 2B 0 795580000.0 191750000.0 290050000.0 313780000.0 False True 185663001.20864338 405868477.5907683 231591604.80177626 1.0 2.1860493202663656 1.24737617777448 27.46811110376901 -10.45758990762344 5.170259491997036 0.9988755399791229 1.7167127490204275 0.4373553287976222 0.38321170572671204 0.004973925034676017 0.0005218121164287235 0.37155801184731047 0.12368104619593269 3.4866639576222884e-11 10.45758990762344 0.7178372090413045 QTEATNAIAEMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QTEATNAIAEMK 12 0 F5GXC2;S4R3G4;F8WBN2;F6SRV7;Q8NHM5-5;Q8NHM5-4;Q8NHM5-2;Q8NHM5-3;Q8NHM5 F5GXC2 KDM2B Lysine-specific demethylase 2B 0 1061670000.0 400300000.0 269770000.0 391600000.0 False True 607284365.850005 221627435.77736944 314200088.3556224 1.0 0.3649483639631682 0.517385439218153 29.177796987498148 -10.27046524865155 8.440288811958736 1.0000003888643447 0.44116690159177946 0.9471440046201531 0.06223217537615879 4.5539219331636725e-07 3.936096701257488e-08 0.060256086904674704 0.02008534823584353 5.364567958889542e-11 10.27046524865155 -0.5588334872725653 QTEATNAIAEMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTEATNAIAEMK 12 0 F5GXC2;S4R3G4;F8WBN2;F6SRV7;Q8NHM5-5;Q8NHM5-4;Q8NHM5-2;Q8NHM5-3;Q8NHM5 F5GXC2 KDM2B Lysine-specific demethylase 2B 0 1024760000.0 203830000.0 427170000.0 393760000.0 False True 279191459.29863334 408296216.93771195 300761997.74175686 1.0 1.4624237358958159 1.0772607389112534 28.056679568067775 -10.159337152019456 5.802760567252966 0.9999964277264868 1.2698422374035438 0.3955656750855827 0.1572421350689182 7.26694226220661e-06 1.0529018594566636e-06 0.15225105914826786 0.05074968087033004 6.928876937539821e-11 10.159337152019456 0.26984580967705707 QTEATNAIAEMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTEATNAIAEMK 12 0 F5GXC2;S4R3G4;F8WBN2;F6SRV7;Q8NHM5-5;Q8NHM5-4;Q8NHM5-2;Q8NHM5-3;Q8NHM5 F5GXC2 KDM2B Lysine-specific demethylase 2B 0 611250000.0 191750000.0 302830000.0 116670000.0 False True 159448620.96531245 301198594.6829512 141065157.57886952 1.0 1.8890009387317062 0.8847060371225023 27.248516379203288 -6.673117409212883 1.92655300731929 1.565933441975412 0.8887295249074443 0.292791965335341 0.3773620575045964 0.4540220787685253 3.251786921858617 0.15753227029697797 0.41914798187198293 2.1226705316889767e-07 6.673117409212883 -0.6772039170679678 QTEATNAIAEMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTEATNAIAEMK 12 0 F5GXC2;S4R3G4;F8WBN2;F6SRV7;Q8NHM5-5;Q8NHM5-4;Q8NHM5-2;Q8NHM5-3;Q8NHM5 F5GXC2 KDM2B Lysine-specific demethylase 2B 0 774920000.0 400300000.0 255450000.0 119170000.0 False True 518196241.09266967 241233982.9414031 97482282.78745851 1.0 0.46552630801168415 0.1881184675942596 28.948923309590597 -8.998699579048973 0.24819723012849576 1.3178199304473786 1.1836923977776904e-13 0.9991853103165985 0.009617254455282494 0.464533983121519 0.08336477694159271 0.2415448968299512 0.11432663763008118 1.0029988173801017e-09 8.998699579048973 -1.3178199304472602 QTEDLTSTEMTEK(ub)SIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTEDLTSTEMTEKSIR 16 1 A0A087WTF1;Q6IPU0 A0A087WTF1 CENPP Centromere protein P 1 8052400.0 1625900.0 3860000.0 2566500.0 True False 2131570.6452379967 3284103.046162155 2300943.199606397 1.0 1.5406963186976494 1.079459038689046 21.023485439707223 -10.06478204324826 4.258333923164729 0.9999689225131783 1.3100776787381743 0.3760149551022969 0.18829933126713475 26863901.73918573 21164720.896434378 7032.619060155755 0.06445986706167803 8.614259623713315e-11 10.06478204324826 0.310108756224996 QTEDLTSTEMTEK(ub)SIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTEDLTSTEMTEKSIR 16 1 A0A087WTF1;Q6IPU0 A0A087WTF1 CENPP Centromere protein P 1 10340200.0 3440600.0 2348800.0 4550800.0 True False 3331380.0362892253 3286688.088830186 3358808.9589263927 1.0 0.986584554457251 1.0082335015334125 21.667688512107247 -6.739081960516374 1.689919825462828 0.9920094393214981 1.0082440078061947 0.6008665750795357 0.0056367408207153675 0.3194828448180944 1.7911003326645205 0.0026390230486850056 0.006482802049665368 1.8235515272610638e-07 6.739081960516374 0.01623456848469662 QTEDLTSTEMTEK(ub)SIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTEDLTSTEMTEKSIR 16 1 A0A087WTF1;Q6IPU0 A0A087WTF1 CENPP Centromere protein P 1 10990500.0 3440600.0 5829200.0 1720700.0 True False 2861011.3444237527 5797796.942594386 2080490.4143821106 1.0 2.0264851287271433 0.727187055177913 21.448093787541524 -6.696112836350344 1.8445636335786246 1.639827806461735 0.7313058978522173 0.39914973181557556 0.4336100465119659 0.403707557463734 2.6675864150642563 0.18772677438425606 0.48514400695972826 2.0132011214571414e-07 6.696112836350344 -0.9085219086095178 QTEEQVNDLK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTEEQVNDLKER 12 1 P12270 P12270 TPR Nucleoprotein TPR 1 6105700.0 2439300.0 1665800.0 2000600.0 True False 3341175.1296038697 1592199.4479360438 1528099.4836503442 1.0 0.47653875842324234 0.4573539022575916 21.671924173664006 QTEEQVNDLK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTEEQVNDLKER 12 1 P12270 P12270 TPR Nucleoprotein TPR 1 9692200.0 3208000.0 4165500.0 2318700.0 True False 2667594.138496596 4143059.6247129873 2803529.4495425127 1.0 1.5531071855810625 1.0509580183447724 21.347107753493187 -10.382024930893747 3.4163228021762997 0.9976744545523653 1.3020326019340496 0.32540488551529967 0.20500154011178012 112916935.69258094 143522658.06955272 2551705.1913569034 0.0810339734781059 4.149302226719902e-11 10.382024930893747 0.3043581473816843 QTEEQVNDLK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTEEQVNDLKER 12 1 P12270 P12270 TPR Nucleoprotein TPR 1 18190500.0 7443600.0 6091700.0 4655200.0 True False 9635886.935292011 5752691.5399653325 3808001.3663856434 1.0 0.5970069572833775 0.39518950273675496 23.19998603483388 -11.778252264685996 0.11427545466442407 2.226647089313366 7.007609193259292e-25 0.9998020256345431 0.003537625380442879 4.993968306767304 0.07877244675593556 1.7918383260704653 0.28867358479339245 1.6662790550351965e-12 11.778252264685996 -2.226647089313366 QTELFAHFIQPAAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTELFAHFIQPAAQK 15 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 3888800.0 2245700.0 1643100.0 0.0 False True 2174411.482734033 2299198.3986533033 0.0 1.0 1.0573888230954187 0.0 21.052193549213797 -6.984312336811616 1.1463166788484358 1.04188223293608 1.5198654034180412e-18 0.9805790914667147 0.06765831440449213 0.09584022162278798 0.24776676932507 0.04956340499031912 0.09180487395719417 1.0367825122196072e-07 6.984312336811616 -1.04188223293608 down QTESTSFLEK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTESTSFLEKK 11 1 G3V5Z7;P60900;G3V295;P60900-2;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 34059550.0 4186590.0 9644760.0 20228200.0 True False 4053688.9920735015 13495962.964758944 14929827.58700776 1.0 3.329303997210607 3.6830224558917153 21.950803975641314 -10.033029579522644 0.4434218837297662 8.868302608854516e-19 3.697077554474763 0.9990538594421563 0.036610120615031196 1.346367981786839 0.2007731161828618 1.8553334226403695 0.08052979679069606 9.2676669973561e-11 10.033029579522644 3.697077554474763 QTESTSFLEK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 QTESTSFLEKK 11 1 G3V5Z7;P60900;G3V295;P60900-2;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 60284200.0 2012600.0 32284600.0 25987000.0 True False 3053261.3407687233 26523160.88926889 20850658.059493255 1.0 8.686829566509076 6.828979157821996 21.541919650154355 -9.847400901989042 7.750093308692459 0.999999972834969 7.757904362165539 0.9463569291246731 0.758464253284103 1.066818361684911e-07 1.1295980228620141e-08 0.7343798554157224 0.2447932851385792 1.4210164256746587e-10 9.847400901989042 6.75790438933057 QTESTSFLEK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTESTSFLEKK 11 1 G3V5Z7;P60900;G3V295;P60900-2;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 14740340.0 3902040.0 2786800.0 8051500.0 True False 5344729.636666046 2663669.9612847664 6149901.52584761 1.0 0.4983731904812157 1.1506478239157139 22.34968554033704 -6.701275191291391 1.8261949785475478 0.6888972896591085 1.1487609689813139 0.42363666727944604 0.2116945475784428 0.3929044753349074 2.5483210290985423 0.09244568888798836 0.2373836093895345 1.9894123456653776e-07 6.701275191291391 0.4598636793222054 QTESTSFLEK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTESTSFLEKK 11 1 G3V5Z7;P60900;G3V295;P60900-2;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 27408590.0 4186590.0 14637700.0 8584300.0 True False 3481335.0823841835 14558843.804744048 10379237.440681325 1.0 4.181971416199747 2.9813956987941337 21.73120925107559 -9.017486506824362 10.69641976940786 0.9999988133662748 3.5816835575006998 0.8604416625795961 0.49013298421753015 0.0 0.0 0.47456922131892615 0.158189740439642 9.60535660983364e-10 9.017486506824362 2.581684744134425 QTFEAAILTQLHPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTFEAAILTQLHPR 14 0 Q9NPD3;E9PI41 Q9NPD3 EXOSC4 Exosome complex component RRP41 0 8238600.0 2695400.0 2613200.0 2930000.0 False True 3533695.502290732 2223320.7461738163 2626831.7065446107 1.0 0.6291772295412946 0.7433667402416978 21.75274629787764 -10.606779928769864 9.535032808243137 1.000055871074253 0.6862719848914965 0.9096209930250992 0.04661767253234459 5.5378164336665076e-05 2.2837594698057154e-06 0.04514533791538663 0.01504578911306013 2.4729769659454797e-11 10.606779928769864 -0.31378388618275654 QTFEAAILTQLHPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTFEAAILTQLHPR 14 0 Q9NPD3;E9PI41 Q9NPD3 EXOSC4 Exosome complex component RRP41 0 7230200.0 3087000.0 1765000.0 2378200.0 False True 2989004.8747383654 2469773.7043534094 1755278.0755293001 1.0 0.8262862751502185 0.5872449691748809 21.511233819219115 -6.9666507087870215 0.3284911640206883 1.029639982261024 0.37608352267232625 0.9999432383462598 0.0012748100267092168 0.07740518160239147 0.012908464781479893 0.003506987521186505 0.020875262824713265 1.0798148387209771e-07 6.9666507087870215 -0.6535564595886978 QTFEAAILTQLHPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QTFEAAILTQLHPR 14 0 Q9NPD3;E9PI41 Q9NPD3 EXOSC4 Exosome complex component RRP41 0 26440600.0 2571300.0 14662000.0 9207300.0 False True 3900850.087209888 12045451.545271128 7387473.119297057 1.0 3.0879042454786383 1.8938110806972854 21.895357124827207 -10.406403902777665 5.968587674549623 0.9995729233721694 2.4908576630879624 0.6751587238857928 0.4874864931765739 0.0027710925972113227 0.0002755947310243465 0.4721255586055692 0.15733558913116008 3.9227993730878276e-11 10.406403902777665 1.491284739715793 QTFEAAILTQLHPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTFEAAILTQLHPR 14 0 Q9NPD3;E9PI41 Q9NPD3 EXOSC4 Exosome complex component RRP41 0 7493600.0 2695400.0 2638900.0 2159300.0 False True 3691962.220446143 2522304.672324668 1649317.8121794402 1.0 0.683188104785067 0.44673203941402573 21.81595635940053 -7.627186207104736 0.16435243132950708 1.2788385383029723 2.687897642748533e-12 0.9999682599968264 0.0012769692777778968 0.13476133764638235 0.018103619326489392 0.048201282585497544 0.07901037599564892 2.359466376890071e-08 7.627186207104736 -1.2788385383002845 down QTFEAAILTQLHPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTFEAAILTQLHPR 14 0 Q9NPD3;E9PI41 Q9NPD3 EXOSC4 Exosome complex component RRP41 0 6736700.0 3087000.0 1347800.0 2301900.0 False True 2566977.277287714 1340539.133882645 2783216.6472169324 1.0 0.5222247760989407 1.0842389108164208 21.29163909465339 -6.681466520477782 1.8964538275605716 0.6981110796295227 1.0821371034595568 0.3309642075733681 0.20242678219788174 0.43526393979550165 3.0278220550908896 0.08560504588166473 0.22537269109851776 2.0822529187628134e-07 6.681466520477782 0.38402602383003415 QTFLLQTTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTFLLQTTK 9 0 O94776;O94776-2 O94776 MTA2 Metastasis-associated protein MTA2 0 10523900.0 1897500.0 1832000.0 6794400.0 False True 2487640.875416141 1558672.7410800685 6091380.664486925 1.0 0.6265666224106116 2.4486575713899774 21.24634679729579 -6.853309586533218 1.2190989697326167 0.8000194591716007 2.526246393738166 0.9449723356978955 0.18434508010898168 0.15385564223826848 0.4383720770125085 0.11821963135700794 0.2741953374576938 1.401814066081742e-07 6.853309586533218 1.7262269345665655 up QTFLLQTTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTFLLQTTK 9 0 O94776;O94776-2 O94776 MTA2 Metastasis-associated protein MTA2 0 6338800.0 1897500.0 1657300.0 2784000.0 False True 2599057.028009408 1584075.0060417843 2126476.538279793 1.0 0.609480665091451 0.8181723276416295 21.30955685881868 -10.120713858288502 5.720934598112996 1.000002668645441 0.713826496366516 0.7148715113423532 0.08519801447025785 2.899971645310132e-06 4.456409564943068e-07 0.08249339219609926 0.027497540931091392 7.573317105184067e-11 10.120713858288502 -0.2861761722789251 QTFSPFGQIMEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTFSPFGQIMEIR 13 0 Q01085;Q01085-2;F8WE16;P31483-2;C9JTN7;F8W8I6;P31483 Q01085;P31483-2;F8W8I6 TIAL1;TIA1 Nucleolysin TIAR;Nucleolysin TIA-1 isoform p40 0 10281400.0 1800200.0 5838200.0 2643000.0 False True 2360079.6331616 4967163.317125359 2369527.713446212 1.0 2.1046592018894157 1.004003288766979 21.17040410875412 -6.645322735043797 2.0251041833147725 1.719439924890535 1.0086019138911477 0.17537536054607172 0.4720246749132752 0.520075194125677 4.082582623284853 0.1893825866190822 0.5227884983332952 2.2629620191691848e-07 6.645322735043797 -0.7108380109993873 QTGGEEGDGASGYDAYWK(ub)NLSSDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTGGEEGDGASGYDAYWKNLSSDK 24 1 Q9Y3S2 Q9Y3S2 ZNF330 Zinc finger protein 330 1 22627400.0 6130500.0 7716100.0 8780800.0 True False 8037144.86784645 6564887.957122228 7872247.047381189 1.0 0.8168184181158461 0.9794830349363299 22.938251655734774 -10.281236754889163 6.52406963937237 1.0000020830345342 0.898150726539621 0.34328008110621233 0.0664075517359219 2.0120939692664366e-06 2.2162136606492595e-07 0.0643001499964801 0.02143294516130273 5.23315074498527e-11 10.281236754889163 -0.10185135649491317 QTGGEEGDGASGYDAYWK(ub)NLSSDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTGGEEGDGASGYDAYWKNLSSDK 24 1 Q9Y3S2 Q9Y3S2 ZNF330 Zinc finger protein 330 1 38596600.0 6847600.0 10915000.0 20834000.0 True False 6630226.686186734 15273416.42097307 15376950.393397288 1.0 2.303603955622417 2.3192194054893 22.660626765973753 -10.844416721271731 0.7665896190117483 4.461948859397204e-07 2.3160620382321273 0.9999821841321587 0.0026095060549586025 2.665198081691723 0.40241461932348555 4.849747450769211 0.002305583444651655 1.4308143222596724e-11 10.844416721271731 2.3160615920372414 QTGGEEGDGASGYDAYWK(ub)NLSSDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QTGGEEGDGASGYDAYWKNLSSDK 24 1 Q9Y3S2 Q9Y3S2 ZNF330 Zinc finger protein 330 1 72253000.0 18527000.0 35774000.0 17952000.0 True False 28106813.505128708 29389850.196462266 14403779.33135887 1.0 1.0456486001552414 0.5124657524315441 24.74441656755876 -6.886074752189676 1.0453030123470644 1.031401843191276 0.46998095024513753 0.9782654550830395 0.035574879572402664 0.12238661270100279 0.24090403586466252 0.026055360080317367 0.06410435652161346 1.2999458078426445e-07 6.886074752189676 -0.5614208929461384 QTGGEEGDGASGYDAYWK(ub)NLSSDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTGGEEGDGASGYDAYWKNLSSDK 24 1 Q9Y3S2 Q9Y3S2 ZNF330 Zinc finger protein 330 1 25657300.0 6130500.0 5215800.0 14311000.0 True False 8397111.520533156 4985348.709655916 10931036.544296747 1.0 0.593698046937381 1.3017615066284967 23.001461717257666 -6.751114926070235 1.646042883782047 0.7614081994234798 1.3032618857123976 0.6536374862119102 0.17073954272995995 0.29809738475025893 1.5895062803664064 0.08193412623710196 0.19865630743292392 1.7737200444663684e-07 6.751114926070235 0.5418536862889178 QTGGEEGDGASGYDAYWK(ub)NLSSDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTGGEEGDGASGYDAYWKNLSSDK 24 1 Q9Y3S2 Q9Y3S2 ZNF330 Zinc finger protein 330 1 28727600.0 6847600.0 10542000.0 11338000.0 True False 5694082.800115116 10485208.15357683 13708723.379011085 1.0 1.8414217919986786 2.407538467606045 22.44103204140803 -8.184211506234822 0.144838354303727 2.7236472631956973e-21 3.5619808722075543 0.9999395676004386 0.004495425626348871 0.08768928005297517 0.029125327382102096 0.31196623812938823 0.33417740924494693 6.543174366024738e-09 8.184211506234822 3.5619808722075543 QTGGEEGDGASGYDAYWK(ub)NLSSDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTGGEEGDGASGYDAYWKNLSSDK 24 1 Q9Y3S2 Q9Y3S2 ZNF330 Zinc finger protein 330 1 66466000.0 18527000.0 31064000.0 16875000.0 True False 23983566.721768353 29335261.092549417 13803923.152121877 1.0 1.2231400538904695 0.5755575604020955 24.515542889651208 -6.813678709243302 1.3990993224538888 1.1210895000481595 0.5632577701344322 0.869203162925792 0.09714088555806315 0.20182154302453595 0.7779154395143826 0.05458437500915767 0.12606265639080977 1.5357527114333402e-07 6.813678709243302 -0.5578317299137273 QTGIVLNRPVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTGIVLNRPVLR 12 1 Q13435;E9PPJ0;E9PJ04;H0YCG1;E9PJT3 Q13435 SF3B2 Splicing factor 3B subunit 2 0 33231000.0 0.0 0.0 33231000.0 False True 0.0 0.0 24526804.19136919 0.0 QTGIVLNRPVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTGIVLNRPVLR 12 1 Q13435;E9PPJ0;E9PJ04;H0YCG1;E9PJT3 Q13435 SF3B2 Splicing factor 3B subunit 2 0 7907500.0 0.0 0.0 7907500.0 False True 0.0 0.0 6039911.360074526 0.0 QTIDNSQGAYQEAFDISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTIDNSQGAYQEAFDISK 18 0 P27348 P27348 YWHAQ 14-3-3 protein theta 0 30321800.0 3070800.0 14249000.0 13002000.0 False True 4025848.5376694994 12123104.742166983 11656677.763990782 1.0 3.011316652559626 2.895458598335309 21.9408614648662 -10.412469833798394 6.27403866006338 0.9995976523669968 2.953387625447468 0.9973685656304454 0.047298852573547615 0.00026624148235304695 2.4932108089462136e-05 0.04580478916690914 0.015265639026005718 3.868389236267261e-11 10.412469833798394 1.9537899730804709 QTIDNSQGAYQEAFDISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTIDNSQGAYQEAFDISK 18 0 P27348 P27348 YWHAQ 14-3-3 protein theta 0 25498700.0 7317600.0 2839100.0 15342000.0 False True 7085306.79345172 3972767.4357109135 11323469.94986566 1.0 0.5607050691697031 1.598162264523376 22.756398892447532 -6.7916565535706175 1.4896181734926917 0.7550045917173485 1.6097183309070495 0.8066669644808179 0.1869555277065852 0.23289485602750357 1.0208673678796798 0.09877634175806971 0.2309926437062748 1.615635720122079e-07 6.7916565535706175 0.8547137391897011 QTIDNSQGAYQEAFDISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTIDNSQGAYQEAFDISK 18 0 P27348 P27348 YWHAQ 14-3-3 protein theta 0 25901200.0 3070800.0 13412000.0 9418400.0 False True 4206157.745249686 12819413.492447002 7193967.898036783 1.0 3.047772877021762 1.71034191624445 22.00407152638909 -10.20442007171632 5.590583191822899 0.9999746221401955 2.3790573960138035 0.5863705372439585 0.5460039035240326 0.00033472578267907543 4.763546663555046e-05 0.5286846421682904 0.17622200208330832 6.245682862969242e-11 10.20442007171632 1.379082773873608 QTIDNSQGAYQEAFDISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTIDNSQGAYQEAFDISK 18 0 P27348 P27348 YWHAQ 14-3-3 protein theta 0 13241600.0 7317600.0 2890700.0 3033300.0 False True 6084908.6246454725 2875127.225340978 3667549.005605419 1.0 0.4725012983261507 0.6027286902470295 22.536804167881808 -10.11816474258594 7.73400253869146 1.0000000699660925 0.5376149942866633 0.9438485735101214 0.05316511012326625 6.413590295149289e-08 7.339390707322735e-09 0.0514769041972484 0.017158965508891132 7.61789982503865e-11 10.11816474258594 -0.4623850756794292 QTIDNSQGAYQEAFDISK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTIDNSQGAYQEAFDISKK 19 1 P27348 P27348 YWHAQ 14-3-3 protein theta 1 27439400.0 9699600.0 8817800.0 8922000.0 True False 9391691.50729261 12338793.524219515 6585060.545737284 1.0 1.3137988523833533 0.7011580970929477 23.162953589760154 -6.767483239884271 1.584215770510505 1.1805639868234032 0.6980444347829857 0.7208095287582936 0.13216720115081115 0.27051052947526527 1.33948254241179 0.0657768330600268 0.15693230270283393 1.7081136376134442e-07 6.767483239884271 -0.4825195520404175 QTIDNSQGAYQEAFDISK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTIDNSQGAYQEAFDISKK 19 1 P27348 P27348 YWHAQ 14-3-3 protein theta 1 23359100.0 9699600.0 7808700.0 5850800.0 True False 8065647.165137655 7766632.98319441 7074175.228957311 1.0 0.9629274408090052 0.8770747199969511 22.94335886519443 -6.957080616264122 0.47479942108090745 1.0021650100292305 0.8342890661556821 0.9996460930906645 0.0009685265551478765 0.08076107096657295 0.02511400557363179 0.0011980234560559813 0.007083756573963295 1.1038736934365451e-07 6.957080616264122 -0.16787594387354843 QTIDNSQGAYQEAFDISK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTIDNSQGAYQEAFDISKK 19 1 P27348 P27348 YWHAQ 14-3-3 protein theta 1 51905000.0 10433000.0 16882000.0 24590000.0 True False 13505724.165175669 15942501.859529337 20114872.314706754 1.0 1.1804255487933677 1.489359035376473 23.687067662184884 -6.962964968060274 0.3914102887446552 0.9813220336145636 1.699587976223861 0.9998648560354246 0.002349005709425029 0.07865848014787838 0.017338417881719904 0.00398569210692898 0.025971508594234933 1.0890179343574046e-07 6.962964968060274 0.7182659426092974 QTIDNSQGAYQEAFDISKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTIDNSQGAYQEAFDISKK 19 1 P27348 P27348 YWHAQ 14-3-3 protein theta 1 16269500.0 5269000.0 5032500.0 5968000.0 True False 6907710.025068586 4281670.616531359 5350488.609098372 1.0 0.6198393680384473 0.7745676338006455 22.719776091366437 -10.11459109363553 5.155325898905001 1.000008252383142 0.6972035023385301 0.8362330655094661 0.06316754998540694 5.9915332337588e-06 1.0291173841462813e-06 0.06116338271154575 0.020387239092627484 7.680843324425092e-11 10.11459109363553 -0.3028047500446118 QTK(ub)EQSQLTATQTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTKEQSQLTATQTR 14 1 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 8819100.0 3004800.0 4134200.0 1680100.0 True False 3939321.898524593 3517393.47498538 1506259.3686572004 1.0 0.892893133791062 0.38236513985347187 21.909515879759372 -6.940878103281842 0.6513497195260232 1.0056551076584828 0.2410643306269759 0.9982765827172443 0.01118727877984044 0.08736848506371268 0.052803809369063814 0.010963780092756632 0.04377296009604518 1.1458345063558108e-07 6.940878103281842 -0.7645907770315068 down QTK(ub)NDPFTSDPFTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTKNDPFTSDPFTK 14 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 77941000.0 21647000.0 27227000.0 29067000.0 True False 20959827.83396871 38098883.08692931 21453480.708691515 1.0 1.8177097344847486 1.0235523344291388 24.321123530700465 -10.238876000316726 4.01807916726976 0.9996677220285682 1.4206310344136635 0.27222377053306546 0.32421340175392793 152522450.02851367 137610578.58123866 597777.0445357198 0.11864994737687173 5.769311651620457e-11 10.238876000316726 0.4209633123850952 QTK(ub)NDPFTSDPFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QTKNDPFTSDPFTK 14 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 102945000.0 32256000.0 42524000.0 28165000.0 True False 48934710.22947224 34935259.95847155 22598175.404841952 1.0 0.7139157419068736 0.46180257937302743 25.5443548208358 -7.006302702217065 0.18812493257593013 1.1772947644480651 8.27504582423547e-09 0.9999962583402849 0.0004252519366069377 0.07262714807411674 0.005920345137743741 0.009069214772553463 0.02692922361105866 9.85592290698774e-08 7.006302702217065 -1.1772947561730194 down QTK(ub)NDPFTSDPFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTKNDPFTSDPFTK 14 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 58796000.0 16965000.0 20933000.0 20898000.0 True False 23237418.96188647 20008110.843825933 15962322.807820093 1.0 0.8610298276518067 0.6869232264564822 24.46994649811419 -6.968076924042516 0.30060230630382834 1.0299805976858591 0.5125123709729557 0.9999632492343893 0.0007764369486578528 0.07693187482123713 0.011252324935093181 0.0028798870453406763 0.015604894615963861 1.076274562524957e-07 6.968076924042516 -0.5174682267129035 QTK(ub)NDPFTSDPFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTKNDPFTSDPFTK 14 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 85042000.0 21647000.0 43592000.0 19803000.0 True False 18000439.624699432 43357161.24366549 23943715.741273247 1.0 2.408672351767045 1.330173942441867 24.10152880613474 -10.224032734573756 5.718114324124443 0.999968219432732 1.8694231471044753 0.4642341836569428 0.4402951318750675 0.00017839271982767556 2.4208381756057534e-05 0.4263294293797382 0.14210464276401802 5.969902872575463e-11 10.224032734573756 0.8694549276717434 QTK(ub)NDPFTSDPFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTKNDPFTSDPFTK 14 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 102140000.0 32256000.0 45482000.0 24402000.0 True False 41756027.86081722 42950886.71810878 19961086.385663893 1.0 1.0286152423615176 0.4780408340611072 25.31548114292825 -6.894646451493817 0.994515565587351 1.0263728548454336 0.4261451716323432 0.9837086427845492 0.03230103867884624 0.11545313664429584 0.20048524775097767 0.024584412596806434 0.062407005916843915 1.274540230801392e-07 6.894646451493817 -0.6002276832130904 down QTLGYHVYPTCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTLGYHVYPTCR 12 0 O43847-2;G3V1R5;O43847 O43847-2 NRD1 Nardilysin 0 6402100.0 1454800.0 2656100.0 2291200.0 False True 1907256.8883032398 2259820.2333967085 2054128.6027423234 1.0 1.1848536226324085 1.0770067814880173 20.863067742561213 -10.785246550304368 5.614992881620176 0.9918491904286652 1.1309302020602128 0.6627529691468614 0.044028288529125485 0.004720532161897003 0.00018054328573959835 0.04479452247564948 0.014210069019609823 1.639658669692613e-11 10.785246550304368 0.13908101163154762 QTLK(ub)MIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTLKMIR 7 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 31029200.0 13776000.0 14218000.0 3035200.0 True False 18060469.406973764 12096729.821329925 2721146.619694266 1.0 0.6697904439105533 0.1506686541958615 24.106332054389803 -7.379201926486889 0.4927459497963558 1.0134274381634896 5.250658185151055e-26 0.9981342975684924 0.015099912617593424 0.10829189084494203 0.05504262591769548 0.017095890741424195 0.0614232914998733 4.176361403547129e-08 7.379201926486889 -1.0134274381634896 down QTLK(ub)MIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTLKMIR 7 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 39090200.0 20239000.0 15497000.0 3354200.0 True False 19596524.023268472 21685032.91578738 2475634.396156916 1.0 1.10657547685697 0.1263302814936671 24.224094440025496 -6.879967979380749 1.0800242432453422 1.066018017181372 0.05691638883040934 0.9736575847821407 0.07127275917689058 0.12765631502418742 0.2724829850880589 0.05083810499135769 0.1229248022732049 1.3183539374733297e-07 6.879967979380749 -1.0091016283509626 down QTLK(ub)MIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTLKMIR 7 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 26880300.0 13776000.0 11084000.0 2020300.0 True False 18869359.482401878 10594272.230113523 1543146.7493845783 1.0 0.5614537281985673 0.08178055809598427 24.169542115912694 -7.756940893815445 0.4955953741515065 1.0211582058638402 6.2826035145773805e-22 0.99538872367564 0.02546399741109928 0.11397153813223812 0.09759042200333201 0.031925864420482376 0.07675727491533674 1.7500848537499054e-08 7.756940893815445 -1.0211582058638402 down QTLK(ub)MIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTLKMIR 7 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 49426340.0 20239000.0 28513000.0 674340.0 True False 16829625.23972337 28359394.809612617 815341.3762041213 1.0 1.6850877191653237 0.04844679335340465 24.004499715459772 -6.792996669807069 1.484304325917303 1.3814060233622156 0.02956534870090216 0.8109038642630962 0.29182963122141053 0.2309093037673064 1.0049118581316834 0.15472897246623238 0.36148922170908665 1.610657985741073e-07 6.792996669807069 -1.3518406746613134 QTLLALEK(ub)EEEEEVFESSVPQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTLLALEKEEEEEVFESSVPQR 22 1 O60566;O60566-3;O60566-2;H0YMK5 O60566 BUB1B Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 1 30851600.0 13876000.0 6346600.0 10629000.0 True False 13435513.9753384 8880830.477081766 7844946.036834984 1.0 0.6609967056997599 0.5838962358444046 23.679548176890375 -13.999999999999998 0.20807493221770587 2.9452305816212365 0.5376275005905783 0.9994890206062099 0.004085649433425892 12.70229591831598 0.14459408942217006 10.092253338338207 0.04629429592988843 1.0000000000000041e-14 13.999999999999998 -2.407603081030658 QTLLALEK(ub)EEEEEVFESSVPQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTLLALEKEEEEEVFESSVPQR 22 1 O60566;O60566-3;O60566-2;H0YMK5 O60566 BUB1B Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 1 32450100.0 13876000.0 9659000.0 8915100.0 True False 11538508.811028307 9606965.04983861 10779206.19123492 1.0 0.8326002265263636 0.9341940425553379 23.45995345232465 -10.260290415353014 4.984980643197079 1.0000239480708293 0.8833971345468871 0.6372075261052469 0.041475501715786144 1.1041203128347393e-05 1.6384082944515716e-06 0.040166726405745964 0.013386160618366293 5.491735153847235e-11 10.260290415353014 -0.11662681352394222 QTLLALEK(ub)EEEEEVFESSVPQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTLLALEKEEEEEVFESSVPQR 22 1 O60566;O60566-3;O60566-2;H0YMK5 O60566 BUB1B Mitotic checkpoint serine/threonine-protein kinase BUB1 beta 1 51101000.0 12884000.0 20326000.0 17891000.0 True False 16678591.981608663 19194840.23200999 14635021.577162212 1.0 1.150866946872732 0.8774734457980699 23.991494164811147 -6.756875746455329 1.624028956995392 1.0879697657181298 0.8766187503409502 0.6781802766204768 0.06343008596057058 0.28818941010867893 1.4972846227222454 0.03082621872538236 0.0743165475230787 1.7503473990153974e-07 6.756875746455329 -0.2113510153771796 QTLLFSATFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTLLFSATFR 10 0 Q86XP3;A0A0A0MSJ0;Q86XP3-2 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 6338600.0 1677800.0 2446000.0 2214800.0 False True 2199612.0478383102 2081066.3344333214 1985633.7418617762 1.0 0.9461060810602985 0.9027199791041228 21.06881766306749 -6.973585977640249 0.14947225346864568 1.0508090848202987 0.7968763945194587 0.999998546156162 4.7630203993268e-05 0.07515531908286908 0.00456645994295096 0.002225933287865523 0.005424056531373015 1.0627081772264115e-07 6.973585977640249 -0.25393269030084 QTLLFSATFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTLLFSATFR 10 0 Q86XP3;A0A0A0MSJ0;Q86XP3-2 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 12219200.0 6051500.0 2437800.0 3729900.0 False True 5859398.444923624 3411226.2529590554 2752927.295398511 1.0 0.5821802843796058 0.4698310451619056 22.482321127303877 -13.999999999999998 0.18434044120606055 3.197728533454147 0.3844742845354951 0.9994935405882465 0.005133353607198979 12.26399234282238 0.13613763762672162 9.664465096367094 0.08088922930762463 1.0000000000000041e-14 13.999999999999998 -2.813254248918652 QTLLFSATFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QTLLFSATFR 10 0 Q86XP3;A0A0A0MSJ0;Q86XP3-2 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 95729000.0 26460000.0 31704000.0 37565000.0 False True 40141754.48511392 26046173.49551737 30140261.2846756 1.0 0.6488548851340386 0.7508456386940623 25.25860033850192 -10.316872671131923 8.224685710582763 1.0000007224875846 0.6998502619140509 0.9203037093996058 0.04163755078400084 5.516104370548683e-07 4.5870486345202655e-08 0.04031548190351618 0.013438461730275068 4.82089118472555e-11 10.316872671131923 -0.3001504605735338 QTLLFSATFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTLLFSATFR 10 0 Q86XP3;A0A0A0MSJ0;Q86XP3-2 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 7878700.0 1677800.0 2466000.0 3734900.0 False True 2298128.000840146 2357043.9660285064 2852793.542680031 1.0 1.025636502913163 1.2413553734331209 21.132027724590383 -6.9291668593665845 0.7535882782073549 0.9966163323700092 1.2847178243457171 0.9963722151672748 0.006519448275048648 0.09307233972157133 0.07981309855569264 0.005910407041027802 0.019608949582403726 1.1771536149197601e-07 6.9291668593665845 0.2881014919757079 QTLLFSATFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTLLFSATFR 10 0 Q86XP3;A0A0A0MSJ0;Q86XP3-2 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 12366100.0 6051500.0 2669000.0 3645600.0 False True 5032090.376905283 2654621.567244977 4407878.104650098 1.0 0.5275385313881346 0.8759536841547998 22.262726402738153 -10.271477330020698 5.805443273684811 1.0000175868572185 0.701746107771466 0.4941959657346743 0.1422398904887047 3.237971592437232e-05 4.0632764565230605e-06 0.1377312950830093 0.045907727252425486 5.352080906670479e-11 10.271477330020698 -0.2982714790857526 QTLLFSATFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTLLFSATFR 10 0 Q86XP3;A0A0A0MSJ0;Q86XP3-2 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 84595000.0 26460000.0 32516000.0 25619000.0 False True 34252991.604576595 30706456.01613879 20956604.87313837 1.0 0.8964605594343489 0.6118182351797362 25.02972666059437 -6.953395783003499 0.5202299645078512 1.0048282360285345 0.49074296007666335 0.9994415305976344 0.003878539572558692 0.08215014514739913 0.030535838976810604 0.004392282140180202 0.023512137886272547 1.1132795127679524e-07 6.953395783003499 -0.5140852759518713 QTLMWSATWPK ddPTM_RPMI8226_Bortezomib_1h_R1 2 QTLMWSATWPK 11 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 187866800.0 51073400.0 65479800.0 71313600.0 False True 66957721.99550908 55710469.07826136 63934752.76035484 1.0 0.8320245584519425 0.9548525674849423 25.996747110234697 -10.324044843553452 5.100505633589236 1.0000380089108178 0.8934385629796182 0.500888821893557 0.05014432470886303 2.1680987286451404e-05 2.8732763399478527e-06 0.04856934183064954 0.016184011208678226 4.7419301941153835e-11 10.324044843553452 -0.10659944593119963 QTLMWSATWPK ddPTM_RPMI8226_Bortezomib_2h_R1 2 QTLMWSATWPK 11 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 153257100.0 55180500.0 19891000.0 78185600.0 False True 53428825.23177858 27833580.030194707 57706445.8422772 1.0 0.5209468841856504 1.080062037522666 25.67111496041172 -6.679889505287498 1.9024330428089962 0.6968668762325531 1.0779249574474667 0.3235816937145819 0.20303893130411346 0.438750380949871 3.07009027590797 0.0856441812396322 0.2259000833249379 2.0898277644691022e-07 6.679889505287498 0.3810580812149137 QTLMWSATWPK ddPTM_RPMI8226_Bortezomib_8h_R1 2 QTLMWSATWPK 11 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 143580300.0 31056900.0 52544400.0 59979000.0 False True 47115587.863519855 43167441.288729005 48124124.3602704 1.0 0.9162029647973939 1.0214055802438884 25.48970110861224 -6.694522372808075 1.8504595704362699 0.9476887189495066 1.0210620523861662 0.3916352136424823 0.03540839050444602 0.40701166133154515 2.7055205080004834 0.015288454279684147 0.03958509349659468 2.0205873381595585e-07 6.694522372808075 0.07337333343665964 QTLMWSATWPK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QTLMWSATWPK 11 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 158090200.0 51073400.0 46813100.0 60203700.0 False True 69956616.18673804 44744742.4517798 45984825.994121805 1.0 0.6396070149010757 0.6573334803869392 26.05995717175759 -10.608975328934726 9.93924725804963 1.000045653197299 0.6484702476477611 0.9980964942528648 0.007236799230570416 7.321991768022209e-06 2.880498628474681e-07 0.007007903100636902 0.0023356669083204867 2.46050737477889e-11 10.608975328934726 -0.3515754055495379 QTLMWSATWPK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 QTLMWSATWPK 11 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 105455100.0 55180500.0 23308100.0 26966500.0 False True 45885030.66063323 23182534.63900439 32605070.47099155 1.0 0.5052308847838191 0.7105818608281952 25.451520235845997 -10.232024494874992 5.525416663452493 1.0000223874758571 0.6079063728059864 0.829380370873734 0.08383418491527661 2.3121558727260074e-05 3.2137188705042797e-06 0.08117672778630941 0.02705736683496749 5.861051063546822e-11 10.232024494874992 -0.3921160146698708 QTLMWSATWPK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 QTLMWSATWPK 11 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 198141900.0 31056900.0 93615000.0 73470000.0 False True 40203769.27302252 88405242.95580138 60099213.8658603 1.0 2.198929218687039 1.4948651569888498 25.26082743070469 -10.278496750874185 5.416204568659327 0.9998952819620266 1.8468971878379892 0.6586090886098079 0.28743294956548715 0.0003635031426121858 4.842238135399675e-05 0.2783396822133773 0.09276858556817784 5.266271547815873e-11 10.278496750874185 0.8470019058759626 QTLQSEQPLQVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTLQSEQPLQVAR 13 0 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 0 5992000.0 1905300.0 0.0 4086700.0 False True 1844817.2944084932 0.0 3016270.6716279536 1.0 0.0 1.6349969619051439 20.815046512166532 -6.741168726745281 1.6823465739412355 0.4058312592289794 1.6362219987542033 0.6102713070479142 0.42014602682348107 0.31567396054367275 1.754721782646324 0.1975302241787828 0.48411422901322626 1.8148104579772175e-07 6.741168726745281 1.2303907395252238 QTLSIYQALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTLSIYQALK 10 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 9206400.0 1843900.0 3055400.0 4307100.0 False True 2417370.7563529997 2599546.2298559174 3861442.608620574 1.0 1.0753609983177588 1.5973729302683357 21.205007328042637 -6.9328766120207295 0.7227865148394054 0.9928471210793318 1.7128380374939407 0.9970741053495458 0.014368294703661475 0.09117123737985405 0.07056196260050797 0.013321880870569628 0.046508454746498076 1.1671411679799194e-07 6.9328766120207295 0.7199909164146089 QTLSTPGTIILGTIPVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTLSTPGTIILGTIPVPK 18 0 Q5TDF0;Q9BSD7 Q5TDF0 NTPCR Cancer-related nucleoside-triphosphatase 0 7432580.0 986980.0 3755800.0 2689800.0 False True 1293940.3379279156 3195449.279993739 2411485.2983835125 1.0 2.4695491641530034 1.8636758030476166 20.303339667211098 -9.920745423850812 5.421261854263561 0.9999983556273541 2.166612483605551 0.831746946059235 0.24734676392727617 4.9163422030016404e-06 9.782089641818765e-07 0.23949281327277058 0.07983082478305545 1.2002026356653845e-10 9.920745423850812 1.166614127978197 QTLSTPGTIILGTIPVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTLSTPGTIILGTIPVPK 18 0 Q5TDF0;Q9BSD7 Q5TDF0 NTPCR Cancer-related nucleoside-triphosphatase 0 3886680.0 986980.0 2899700.0 0.0 False True 1351893.1781316062 2771581.665974394 0.0 1.0 2.0501484220853 0.0 20.36654972873399 -6.7727974389786665 1.5987767965118171 1.604005830052821 3.811062198226849e-12 0.7205556643053876 0.4424871244904656 0.26667943202574285 1.3513244323039506 0.21936935746550887 0.5135339779525396 1.6873398407881197e-07 6.7727974389786665 -1.60400583004901 QTMLFSATQTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTMLFSATQTR 11 0 Q9NVP1;H7C452 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 28559100.0 7554500.0 6724600.0 14280000.0 False True 9904022.657882078 5721315.892285494 12802442.583432425 1.0 0.5776759696457486 1.2926507769288726 23.23958318439904 -6.746663723945192 1.662312090859425 0.7506765098433082 1.2937081519179259 0.6344529057250612 0.17744133039401913 0.305894791834267 1.6620199868217698 0.08436360662822075 0.20552499594765994 1.7919928646387976e-07 6.746663723945192 0.5430316420746176 QTMLFSATQTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTMLFSATQTR 11 0 Q9NVP1;H7C452 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 16787400.0 3535200.0 2507200.0 10745000.0 False True 3422977.011070644 3508338.0348752765 7930562.15690958 1.0 1.0249376561772272 2.316861063121498 21.706820172473634 -6.911076999563732 0.8883530065570352 0.9613487602256278 2.4877334903841697 0.9913220030708707 0.057288995857744475 0.10371064107217344 0.13493043104953634 0.047154398984669034 0.1311622456766701 1.227221627870045e-07 6.911076999563732 1.5263847301585418 up QTNFMTK(ub)LGSISCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTNFMTKLGSISCK 14 1 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 1 250788900.0 71503600.0 120259100.0 59026200.0 True False 93741912.04184741 102316911.04630032 52918735.043291196 1.0 1.0914745476988452 0.5645152087325432 26.48219088579569 -6.862124581709996 1.1748535252013292 1.0499438354777901 0.5379298632571162 0.9561769747997435 0.048127891294000934 0.14463487392520227 0.37813268825268215 0.0319203980943537 0.0747041661202243 1.3736478738762695e-07 6.862124581709996 -0.5120139722206739 QTNFMTK(ub)LGSISCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTNFMTKLGSISCK 14 1 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 1 290279400.0 147788900.0 107107500.0 35383000.0 True False 143097422.2650539 149876083.30823362 26115130.83275301 1.0 1.0473709514530867 0.18249896063383272 27.092422442911076 -6.893947199535202 0.9987225954909229 1.0421693976231132 0.1020894874903702 0.9833073770364671 0.05129372075673133 0.115999591166691 0.20359937264967204 0.03891548045205768 0.09850384162316725 1.2765940045651938e-07 6.893947199535202 -0.9400799101327431 down QTNFMTK(ub)LGSISCK ddPTM_RPMI8226_Bortezomib_8h_R1 2 QTNFMTKLGSISCK 14 1 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 1 430257500.0 104270400.0 155456400.0 170530700.0 True False 158185819.98732516 127713990.83360314 136825232.39873913 1.0 0.8073668729841675 0.8649652188148244 27.237045039371957 -9.91537595432585 6.0069740633343205 1.0000000500144388 0.8361660458994373 0.9151653890020179 0.02351442621912083 1.575653958273534e-08 2.8239346604793957e-09 0.022767752070785203 0.00758924842849259 1.2151336443316334e-10 9.91537595432585 -0.16383400411500149 QTNFMTK(ub)LGSISCK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 QTNFMTKLGSISCK 14 1 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 1 370383000.0 94761800.0 192091700.0 83529500.0 True False 129797798.30135535 183604453.53169402 63801552.444052406 1.0 1.414542125787174 0.49154572172266336 26.951690670890066 -6.784605973155886 1.5178317737293103 1.2333216699306697 0.48313807942627396 0.7833729611044753 0.17568260458094723 0.24348627123021943 1.1081787156612648 0.09113666191061505 0.21423997806675496 1.6420789234788958e-07 6.784605973155886 -0.7501835905043958 down QTNFMTK(ub)LGSISCK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 QTNFMTKLGSISCK 14 1 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 1 346794300.0 189849600.0 80160200.0 76784500.0 True False 157868354.16331786 79728361.09204601 92839783.93858495 1.0 0.5050306726423808 0.5880835613357975 27.234146760776436 -10.77782371788643 7.100376300746619 1.0119946445264394 0.5465571169890892 0.9754566657526647 0.03390619982717289 0.006363565208717082 0.00019912062039608997 0.0324500613657212 0.01094317893865178 1.6679240931739126e-11 10.77782371788643 -0.46543752753735024 QTNFMTK(ub)LGSISCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTNFMTKLGSISCK 14 1 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 1 313490100.0 99551000.0 168733000.0 45206100.0 True False 128870731.94358304 159342860.22177252 36979053.65375626 1.0 1.236454995006388 0.28694687378624445 26.941349407015924 -6.840781392724834 1.2788030403482569 1.1257764777421766 0.2552385648671645 0.9257831477017001 0.10994749836903803 0.16788797473491285 0.5329913912514969 0.0674090993248041 0.1553278159699938 1.442841440107794e-07 6.840781392724834 -0.8705379128750121 down QTPLTCSGHTRPVVDLAFSGITPYGYFLISACK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QTPLTCSGHTRPVVDLAFSGITPYGYFLISACK 33 1 Q9Y3F4;Q9Y3F4-2;F5H1G1 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 0 165319000.0 44480000.0 49439000.0 71400000.0 False True 67479411.92357776 40616224.18132996 57287758.70426827 1.0 0.6019054260183673 0.8489664783852621 26.007944064946752 -10.466097504861397 5.7323561746137965 1.0002388495372496 0.7254359522018144 0.6221726365125058 0.10086225226898855 0.0003081494375217811 2.8700301333359323e-05 0.09774343588166884 0.03255315194156354 3.419026722192345e-11 10.466097504861397 -0.27480289733543517 QTPLTCSGHTRPVVDLAFSGITPYGYFLISACK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTPLTCSGHTRPVVDLAFSGITPYGYFLISACK 33 1 Q9Y3F4;Q9Y3F4-2;F5H1G1 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 0 80995400.0 44480000.0 9769400.0 26746000.0 False True 57580236.83188086 9225724.302007213 21878502.437134888 1.0 0.16022379916470125 0.3799654819241949 25.7790703870392 -10.142546936467584 5.772320635758588 1.0000081992200132 0.2700946406021814 0.9363509799749457 0.08970916633034366 9.46604819150291e-06 1.4061727575455313e-06 0.08686150166837607 0.02895350893327903 7.201999112750634e-11 10.142546936467584 -0.7299135586178318 QTPSFWILAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTPSFWILAR 10 0 Q13564;Q13564-4;Q13564-3;Q13564-2 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 0 14117700.0 2784100.0 6776800.0 4556800.0 False True 3649982.0612627524 5765727.85575951 4085306.047912109 1.0 1.57965923091819 1.1192674318236928 21.79945794285358 -9.660342496152456 10.375338406596994 0.9999993232065221 1.3494633313704754 0.43446018847857093 0.18795416492431694 0.0 0.0 0.18198583765036688 0.060661945883455616 2.1860369772210066e-10 9.660342496152456 0.3494640081639533 QTPSFWILAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTPSFWILAR 10 0 Q13564;Q13564-4;Q13564-3;Q13564-2 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 0 13357700.0 2784100.0 4958000.0 5615600.0 False True 3813457.007473511 4738939.166086506 4289310.93691236 1.0 1.2426884993850094 1.124782822647871 21.86266800437647 -10.221451036569741 4.403821898891265 0.9999319239437963 1.183735661018719 0.7640310762315753 0.048134790976874314 33908878.78200181 2.9348957491174845 23548.343793630447 0.01647781925984137 6.005497125456539e-11 10.221451036569741 0.1838037370749228 QTPSFWILAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTPSFWILAR 10 0 Q13564;Q13564-4;Q13564-3;Q13564-2 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 0 8087900.0 3891300.0 2557500.0 1639100.0 False True 3235788.363819143 2543722.2398759965 1981828.2316578825 1.0 0.7861213262024612 0.6124715243486339 21.62568582095693 -6.973497479400974 0.15309133819762816 1.1933400176050974 0.20067348159979234 0.9999984064386276 0.00019999084241140784 0.07518328707797907 0.0046933906161258235 0.008594757382710047 0.0213952413780988 1.0629247523601056e-07 6.973497479400974 -0.9926665360053051 QTQATTLVHQIFGGYLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTQATTLVHQIFGGYLR 17 0 K7EMM6;E9PEW0;A0A075B784;Q9P275 K7EMM6 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 0 14440800.0 4851900.0 3071600.0 6517300.0 False True 4697879.09029578 4298105.898182389 4810223.61519095 1.0 0.9149034735825393 1.0239138817189304 22.163578152390038 -6.698444433381811 1.8365722671964875 0.9470768906295246 1.023578380083555 0.41008952949210997 0.03593080976770952 0.3987875019772722 2.6140250173380792 0.015614803809108764 0.040232120431758 2.0024218087957843e-07 6.698444433381811 0.07650148945403035 QTQATTLVHQIFGGYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTQATTLVHQIFGGYLR 17 0 K7EMM6;E9PEW0;A0A075B784;Q9P275 K7EMM6 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 0 10665600.0 1498000.0 2636700.0 6530900.0 False True 2051851.081927846 2520201.8755990947 4988435.9281075755 1.0 1.2282576926738773 2.431188097442539 20.9684945969746 -6.938639911371003 0.6721078174005805 0.9861272425458507 2.7429893002376824 0.9979801398417822 0.02821610548068525 0.08839282620123992 0.057478822074250764 0.027190925563925335 0.10416967353194052 1.1517549531668475e-07 6.938639911371003 1.7568620576918317 up QTQATTLVHQIFGGYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTQATTLVHQIFGGYLR 17 0 K7EMM6;E9PEW0;A0A075B784;Q9P275 K7EMM6 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 0 13314200.0 4851900.0 4309900.0 4152400.0 False True 4034569.825614596 4286681.713251826 5020647.641471646 1.0 1.0624879227610904 1.2444071756043629 21.943983427824314 -6.952123491768798 0.5350220553066183 0.9972304140185788 1.3179944204119907 0.99935756963839 0.0026277303631891884 0.08264407199584975 0.03251873162306849 0.0029103800765374623 0.015054103416232872 1.1165457125221221e-07 6.952123491768798 0.32076400639341185 QTQIFTTYSDNQPGVLIQVYEGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 QTQIFTTYSDNQPGVLIQVYEGER 24 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 150521000.0 15343000.0 76508000.0 58670000.0 False True 23276452.723548904 62854549.64026766 47073848.78402552 1.0 2.7003491634563974 2.0223807013514854 24.4723678758906 -10.41496069857907 5.721178456587992 0.9993878465354216 2.361364932403944 0.843164783625461 0.27677946564275313 0.0021619627135096085 0.00022107817244303228 0.2680934536289364 0.08933018841721299 3.8462658720194124e-11 10.41496069857907 1.3619770858685223 QTQIFTTYSDNQPGVLIQVYEGER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTQIFTTYSDNQPGVLIQVYEGER 24 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 60336000.0 15343000.0 18153000.0 26840000.0 False True 19861815.95574527 17142769.592230514 21955395.401656337 1.0 0.8631018246482021 1.105407252316497 24.24349419798305 -6.753423790655792 1.6370619958430386 0.9198332620941629 1.1060199746125825 0.6635643472134267 0.05753838582995381 0.2941370880401006 1.5519091323832634 0.027752301244544517 0.06713764831639867 1.7643153367226567e-07 6.753423790655792 0.18618671251841956 QTQTALENEVYCNPK(ub)QSVIDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTQTALENEVYCNPKQSVIDR 21 1 O75665;O75665-3;A6NF31 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 7678800.0 1818300.0 3103500.0 2757000.0 True False 2383808.9084422477 2640469.897348248 2471732.0870114258 1.0 1.1076684410386406 1.0368834843505277 21.184837160035208 -10.435104087830094 5.551404864317388 0.999947152095432 1.0722759626945828 0.581606626301137 0.02889783755848159 1.891540886362993e-05 1.9247448634416034e-06 0.028000657890105102 0.009326736967117048 3.671942840981932e-11 10.435104087830094 0.07232881059915086 QTQTALENEVYCNPK(ub)QSVIDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QTQTALENEVYCNPKQSVIDR 21 1 O75665;O75665-3;A6NF31 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 71333900.0 4624900.0 8004000.0 58705000.0 True False 7016311.4254801 6575623.6644625645 47101931.01868443 1.0 0.9371909634146005 6.713204155623896 22.7422813538834 -6.9044409522613925 0.9327499107378958 0.7882296963729977 7.377313665076274 0.988649554505037 0.28852278415946325 0.10821028734101887 0.15955139345573716 0.2299083435520483 0.6126870847632182 1.2461176509532432e-07 6.9044409522613925 6.589083968703276 up QTQTFTTYSDNQPGVLIQVYEGER ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTQTFTTYSDNQPGVLIQVYEGER 24 0 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 48639700.0 18220200.0 5464900.0 24954600.0 False True 17641809.72423325 7647063.069077016 18418241.638047054 1.0 0.43346250688628674 1.0440108994457227 24.07249522659552 -11.951007088786898 18.277724561287815 0.9124454558927871 0.7648630328494108 0.0 0.28462796381398464 0.0 0.0 0.0 0.08275505172633124 1.1194196115521963e-12 11.951007088786898 -0.14758242304337632 QTQTFTTYSDNQPGVLIQVYEGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 QTQTFTTYSDNQPGVLIQVYEGER 24 0 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 321293000.0 53078000.0 175474000.0 92741000.0 False True 80523206.52157526 144159293.71538028 74410700.70017578 1.0 1.7902825774424975 0.9240901339446572 26.262901287298746 -6.666663373076101 1.9494309929062927 1.5058857048570335 0.927657353071282 0.26422723130070025 0.33595743227804503 0.46884219696658896 3.431791189050949 0.1389074329505829 0.37271691833388665 2.154451028836476e-07 6.666663373076101 -0.5782283517857515 QTQTFTTYSDNQPGVLIQVYEGER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTQTFTTYSDNQPGVLIQVYEGER 24 0 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 29467000.0 18220200.0 5904000.0 5342800.0 False True 15150903.591719365 5872193.980147754 6459954.777683932 1.0 0.38758044657859 0.4263742250471834 23.852900502029797 -9.985272734752497 5.862863451358126 1.000000666597828 0.40697733581273016 0.9968007273960171 0.0158374937409925 1.3801382311261814e-07 2.3852550905869283e-08 0.015334604740858496 0.0051115291252962075 1.0344923066755676e-10 9.985272734752497 -0.5930233307850978 QTQTFTTYSDNQPGVLIQVYEGER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTQTFTTYSDNQPGVLIQVYEGER 24 0 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 151260000.0 53078000.0 56310000.0 41872000.0 False True 68710517.32379897 53176298.99953184 34251725.64300131 1.0 0.7739178959887324 0.49849319983416407 26.034027609391195 -6.968483738306942 0.2921413089257128 1.0524562688873977 0.21141982922185654 0.9999680209737453 0.0011596528359007273 0.07679783631977224 0.010782057961452828 0.004757189478809423 0.024915512740811944 1.0752668618582291e-07 6.968483738306942 -0.8410364396655412 down QTTSNLGHLNK(ub)PSIQALIHGLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QTTSNLGHLNKPSIQALIHGLNR 23 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 330224600.0 5736600.0 60338000.0 264150000.0 True False 8702841.601636613 49570212.47705419 211940636.7189419 1.0 5.695865183589262 24.353038515498824 23.053055107668687 -6.9450299246653975 0.6109817361730137 0.7939132633636621 30.228231396684627 0.9987512275983006 0.3564108458837926 0.08554508080924207 0.04471060762716418 0.3619474733706521 1.573764786335835 1.1349326114809974e-07 6.9450299246653975 29.434318133320964 QTTSNLGHLNK(ub)PSIQALIHGLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTTSNLGHLNKPSIQALIHGLNR 23 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 1 239249600.0 5736600.0 83535000.0 149978000.0 True False 7426141.785291548 78886203.81683336 122683542.90423304 1.0 10.622771029375965 16.52049562899862 22.824181429761136 -8.275406043386166 0.40429695236531865 3.593520818969553e-15 18.07892500921905 0.9964327720539687 0.38205455239805086 0.1234459310602217 0.11572066203306222 1.2435025228153995 1.4494898836269596 5.303883260716915e-09 8.275406043386166 18.078925009219045 QTTSNLGHLNKPSIQALIHGLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTTSNLGHLNKPSIQALIHGLNR 23 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 48363900.0 5975200.0 23903700.0 18485000.0 False True 7833545.063919104 20337361.135892827 16572349.52064064 1.0 2.596188694894428 2.1155619052952166 22.901233914987625 -10.338296811120207 6.185674892554164 0.9998905728327498 2.3558753000948065 0.9138758561929092 0.19621506520501464 0.0002961381111678144 3.167844038632793e-05 0.18999928704257626 0.06332813998450175 4.588842890420574e-11 10.338296811120207 1.3559847272620567 QTTSNLGHLNKPSIQALIHGLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTTSNLGHLNKPSIQALIHGLNR 23 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 140223700.0 33595800.0 18235900.0 88392000.0 False True 32529319.718411148 25517589.96896221 65239483.49684039 1.0 0.7844489276091319 2.0055594172144873 24.95523731600537 -6.861303006924968 1.179035771161511 0.882610476223597 2.0662079339962744 0.9552108502923908 0.11262283580202474 0.14547097549279142 0.38350894620866033 0.07445782651930853 0.17408117103069284 1.376248926033981e-07 6.861303006924968 1.1835974577726773 up QTTSNLGHLNKPSIQALIHGLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QTTSNLGHLNKPSIQALIHGLNR 23 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 70195600.0 13003000.0 28083000.0 29109600.0 False True 19726501.646634035 23071369.236519538 23356074.80080907 1.0 1.169562127629267 1.183994771054317 24.233631791354835 -13.0214138103534 0.3617058712596859 4.219241099475057e-11 1.1857459270189452 0.9997388250456771 0.001350105479123246 10.801144776256109 0.19261032441868134 8.123320458907202 0.0041424377727114475 9.51888740251806e-14 13.0214138103534 1.1857459269767527 QTTSNLGHLNKPSIQALIHGLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTTSNLGHLNKPSIQALIHGLNR 23 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 381435800.0 5975200.0 26770600.0 348690000.0 False True 8184392.913708451 25587786.37346423 266336603.49597043 1.0 3.1264122633464924 32.54201091077505 22.964443976510516 -6.921444769841852 0.8139365551875154 0.3841384775737886 37.44689045208968 0.994572958882642 1.0603872531807932 0.09732927794206142 0.10126301203797529 0.9206906345141564 2.7971890903336516 1.1982715002503633e-07 6.921444769841852 37.06275197451589 up QTTSNLGHLNKPSIQALIHGLNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTTSNLGHLNKPSIQALIHGLNR 23 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 80599000.0 33595800.0 28812700.0 18190500.0 False True 27936396.24629174 28657480.266226865 21994049.446630877 1.0 1.025811633454005 0.7872901448249737 24.735642591439646 -6.880097683654458 1.0792153303380982 1.0160197162468598 0.7703519415205541 0.973765823376256 0.01731083111000071 0.1275453634034236 0.27174205739419216 0.01235470486478229 0.029885237835632593 1.3179602630998795e-07 6.880097683654458 -0.24566777472630574 QTTSNLGHLNKPSIQALIHGLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTTSNLGHLNKPSIQALIHGLNR 23 1 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 82241000.0 13003000.0 39746000.0 29492000.0 False True 16832639.82744935 37534100.16045804 24124758.61347428 1.0 2.229840390171622 1.4332130230775515 24.004758113447284 -10.105734352439185 4.721561883455865 0.9999619410152035 1.8315267066390029 0.592288698877872 0.32522176086272336 226510981.1090065 12.393697085602074 122724.22937594035 0.11133205911785933 7.839089945543906e-11 10.105734352439185 0.8315647656237993 QTTVSNSQQAYQEAFEISK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTTVSNSQQAYQEAFEISKK 20 1 P31946;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 21783000.0 5770000.0 0.0 16013000.0 True False 7469378.743703971 0.0 13098798.307254951 1.0 0.0 1.7536663699502568 22.832556822961177 -6.752032805120631 1.6423459732500607 0.41343358008842046 1.757696836374025 0.6576771435467714 0.4202549259756758 0.29650494515598724 1.5741393945800277 0.20208927420169132 0.4895708869327339 1.7699752553871982e-07 6.752032805120631 1.3442632562856045 QTVADQVLVGSYCVFSNQGGLVHPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTVADQVLVGSYCVFSNQGGLVHPK 25 0 P56537;P56537-2 P56537;P56537-2 EIF6 Eukaryotic translation initiation factor 6 0 15224800.0 7225000.0 2588700.0 5411100.0 False True 6995646.329765051 3622381.4098921632 3993770.58047961 1.0 0.5178051089403517 0.5708937233557576 22.738025923879395 -10.381927149702756 5.294325241565058 1.000243418307621 0.5443494161480417 0.9899213835301565 0.021673336078230254 6.230448838977982e-05 7.273602776909268e-06 0.020996140870704144 0.006995039140638595 4.1502365452712434e-11 10.381927149702756 -0.4558940021595793 QTVADQVLVGSYCVFSNQGGLVHPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTVADQVLVGSYCVFSNQGGLVHPK 25 0 P56537;P56537-2 P56537;P56537-2 EIF6 Eukaryotic translation initiation factor 6 0 15181300.0 2388100.0 4977500.0 7815700.0 False True 3271045.1059758994 4757577.591608629 5969792.62939417 1.0 1.454451845655375 1.8250413662862388 21.641320222880932 -6.973451816746733 0.15492724161546248 0.5977701577670368 2.6915116345329824 0.9999983212971074 0.0004371149954730349 0.07519775667878613 0.004758234938467077 0.018014860966379057 0.04533284043746759 1.0630365164260814e-07 6.973451816746733 2.0937414767659455 QTVAVGVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTVAVGVIK 9 0 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 0 1772130000.0 614670000.0 600890000.0 556570000.0 False True 805838322.4727471 511239554.2508744 498981475.3964271 1.0 0.6344195107054669 0.6192079248170805 29.585915175067832 QTVAVGVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTVAVGVIK 9 0 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 0 997750000.0 355970000.0 151250000.0 490530000.0 False True 344669927.1981264 211644913.75833035 362045477.415435 1.0 0.6140510008483294 1.050412144623574 28.360640186684833 -6.673253841398377 1.925773163745652 0.7543438921439836 1.048678323627465 0.2935702060479318 0.16382061604740766 0.45368785408059253 3.24680333358716 0.06840794747407024 0.1820012788585087 2.1220038064414432e-07 6.673253841398377 0.2943344314834815 QTVAVGVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QTVAVGVIK 9 0 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 0 1868960000.0 261810000.0 1297600000.0 309550000.0 False True 397184910.8748181 1066033141.8049262 248367306.81941527 1.0 2.6839719048161697 0.6253190894698765 28.565235574765865 -6.689260005340779 1.8689465669309053 2.056464158106324 0.6324760071322042 0.3670213946567995 0.7123071553916819 0.41825388050988943 2.831911018614505 0.3049561921278051 0.7948975560501903 2.0452198288739105e-07 6.689260005340779 -1.42398815097412 QTVAVGVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTVAVGVIK 9 0 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 0 1683960000.0 614670000.0 441280000.0 628010000.0 False True 841930109.8321692 421782790.4821813 479686972.27194434 1.0 0.5009712630021745 0.5697467838126913 29.649125236590724 -10.532689640121141 6.281864111406265 1.0005389361665256 0.53535902340756 0.9838335131030971 0.02807748879665534 0.0002121596839955704 1.5782659182912298e-05 0.02721578344262303 0.009061970542730951 2.932988498155789e-11 10.532689640121141 -0.46517991275896553 QTVAVGVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTVAVGVIK 9 0 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 0 731060000.0 355970000.0 247140000.0 127950000.0 False True 296004827.14483565 245808607.7665509 154703753.42604214 1.0 0.8304209432580515 0.5226392924678398 28.14104546211911 -6.961897975408249 0.4078038923691569 1.0155295107813598 0.32614937689368967 0.9998342425818021 0.0025438422602437876 0.07902996711405876 0.018676552057518985 0.003961234416319718 0.025716032855610874 1.091696768063803e-07 6.961897975408249 -0.6893801338876702 QTVAVGVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTVAVGVIK 9 0 P68104;Q5VTE0;A0A087WVQ9;A0A2U3TZH3;Q05639 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 2 0 951380000.0 261810000.0 436920000.0 252650000.0 False True 338918206.04664433 412605017.916453 206670292.40791646 1.0 1.2174176853151033 0.6097940114184158 28.336361896858314 -6.809951993481012 1.4148098888294307 1.1184959162019865 0.5991827228857992 0.8596884851926332 0.09416324294882253 0.20686325721779736 0.8161290968415817 0.05233400946825091 0.12105772837593592 1.5489878331625986e-07 6.809951993481012 -0.5193131933161873 QTVAVGVIK(ub)AVDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTVAVGVIKAVDKK 14 2 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 19360300.0 5219100.0 7051150.0 7090050.0 True False 6842290.641836294 5999145.905167433 6356439.638561973 1.0 0.8767744925195721 0.9289929310655634 22.7060479564803 -10.134795080327788 4.384132068946984 1.000011889881808 0.9028837118592952 0.8218056140918607 0.021318088394099006 17288490744.021667 7480326003.91836 2961726.6316905683 0.007801417825649107 7.331703943079287e-11 10.134795080327788 -0.09712817802251283 QTVAVGVIK(ub)AVDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTVAVGVIKAVDKK 14 2 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 37790200.0 9412900.0 10616000.0 17761300.0 True False 9114092.641860971 14855024.161708662 13109082.7024214 1.0 1.6298961120363895 1.438331078862581 23.119667604497366 -10.424911613234594 5.288945457600872 0.9995146863356096 1.5341135954494944 0.9120113375564881 0.07820609730589319 0.00044793307013374595 4.8705498565955436e-05 0.0757888570713156 0.025240909369795356 3.7591390176754154e-11 10.424911613234594 0.5345989091138849 QTVAVGVIK(ub)AVDKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QTVAVGVIKAVDKK 14 2 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 47568700.0 8627900.0 0.0 38940800.0 True False 13089155.08398016 0.0 31244133.811641015 1.0 0.0 2.387024495559745 23.641868637316442 -6.792906326433389 1.4846862563663068 0.44320625705868366 2.4144892931949804 0.8106098257078777 0.42594595396471563 0.2310448190747615 1.0060262503595534 0.22578151172934893 0.5275162404740841 1.6109930749912526e-07 6.792906326433389 1.9712830361362967 QTVAVGVIK(ub)AVDKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTVAVGVIKAVDKK 14 2 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 29544000.0 9412900.0 16111100.0 4020000.0 True False 7827243.41217414 16024306.306497024 4860563.413620086 1.0 2.0472477298423533 0.62098022990574 22.900072879931642 -6.709943490375592 1.7956474922907146 1.643869159729413 0.624370060726213 0.46473921260361895 0.44130830303108887 0.3751806831208882 2.358150548555763 0.19559144041820398 0.49688339334672355 1.950098326571133e-07 6.709943490375592 -1.0194990990032 QTVAVGVIK(ub)AVDKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTVAVGVIKAVDKK 14 2 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 30990700.0 8627900.0 12576000.0 9786800.0 True False 11168986.63133511 11876134.54480753 8005702.821048079 1.0 1.0633135249252141 0.7167796941029286 23.41299495940889 -6.859568803852625 1.1878298928580513 1.034315608727994 0.7001301219228654 0.9531184197969962 0.032622901768471664 0.14725268279985365 0.3950248076126108 0.021423612674959912 0.04998781851936208 1.3817554815637804e-07 6.859568803852625 -0.3341854868051287 QTVMFSATFPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTVMFSATFPR 11 0 A0A0C4DG89;Q7L014 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 14103800.0 4614500.0 4312700.0 5176600.0 False True 6049654.186881573 3669261.970772932 4640975.0894535165 1.0 0.6065242503827039 0.767147170084082 22.52842124607008 -10.129946775591323 5.205999283909572 1.0000092528552933 0.6868357102330942 0.8352110573591804 0.06557403237844478 7.042463253066709e-06 1.1769717199551598e-06 0.06349365824685349 0.02116392794529843 7.414010972033295e-11 10.129946775591323 -0.3131735426221991 QTVMFSATFPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTVMFSATFPR 11 0 A0A0C4DG89;Q7L014 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 12792800.0 5964000.0 0.0 6828800.0 False True 5774676.0845285505 0.0 5040132.420391262 1.0 0.0 0.8727991573232531 22.461308593887434 -9.07260634340422 11.650177324373512 1.0000232235410902 0.436399578661861 0.3573148054409432 0.3563187641478625 0.0 0.0 0.34500415975744875 0.11500138658581623 8.460453767623725e-10 9.07260634340422 -0.5636236448792291 QTVMFSATFPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTVMFSATFPR 11 0 A0A0C4DG89;Q7L014 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 15685100.0 4614500.0 5865900.0 5204700.0 False True 6320605.352173605 5606725.142062694 3975457.0541612227 1.0 0.8870550888190775 0.6289677701193755 22.591631307592973 -6.95735820243339 0.47119607280059406 1.0067381675939058 0.4986831168541699 0.9996593064132936 0.00286629088029164 0.08065874951977926 0.02472363374561196 0.003576544648185681 0.021299583804970695 1.1031683605876811e-07 6.95735820243339 -0.5080550507397359 QTVMFSATFPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTVMFSATFPR 11 0 A0A0C4DG89;Q7L014 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 11273400.0 5964000.0 3043500.0 2265900.0 False True 4959330.24999804 3027104.06141255 2739689.213662125 1.0 0.6103856587114251 0.5524312912339742 22.24171386932171 -13.999999999999973 0.2683206325940625 3.9802539911526353 0.5328788647146435 0.999579729721571 0.0040742499037614375 14.801406587253734 0.16396359779767555 24.038273614151006 0.02427346145941897 1.0000000000000614e-14 13.999999999999973 -3.4473751264379917 QTVQSK(ub)ILTTGENYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QTVQSKILTTGENYK 15 1 E9PMH5;Q13490-2;Q13490;A0A087X2B2;E9PIW1 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 6670800.0 2638300.0 2006400.0 2026100.0 True False 3458836.849333544 1707052.9408859436 1816458.607723561 1.0 0.49353381360409126 0.5251645818661728 21.721855533827558 -9.943051622663907 5.2201056558068 1.0000014166601863 0.5093491977317111 0.996892692610002 0.012913207083537428 2.2402194225402144e-07 4.5363730796802625e-08 0.012503196992361945 0.004167719662969453 1.1401142591679517e-10 9.943051622663907 -0.4906522189284752 QTVQSK(ub)ILTTGENYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QTVQSKILTTGENYK 15 1 E9PMH5;Q13490-2;Q13490;A0A087X2B2;E9PIW1 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 7894300.0 2638300.0 2962300.0 2293700.0 True False 3613750.807376662 2831415.7909838757 1751975.3002343227 1.0 0.7835116315170861 0.48480799967116106 21.78506559535045 -6.966608522381154 0.32928072249993445 1.0366981743621855 0.22185349633685975 0.9999425642545391 0.0016007272127330128 0.07741929527901503 0.012957855203671336 0.004369796085603894 0.026068751410186542 1.0799197346418353e-07 6.966608522381154 -0.8148446780253258 down QTVQSK(ub)ILTTGENYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTVQSKILTTGENYK 15 1 E9PMH5;Q13490-2;Q13490;A0A087X2B2;E9PIW1 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 34841500.0 6187500.0 11062000.0 17592000.0 True False 8009840.723859327 10446389.975720486 14390436.509163126 1.0 1.3041944697605887 1.7965945897397921 22.93334212417003 -6.963961017893562 0.37546283110427153 0.9644031516901768 2.1536736058558725 0.9998900914463299 0.003440963981809287 0.07831539404856484 0.016114480347956494 0.006441305845026193 0.04170034286679359 1.0865231451418162e-07 6.963961017893562 1.1892704541656958 QTYFLPVIGLVDAEK(ub)LKPGDLVGVNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QTYFLPVIGLVDAEKLKPGDLVGVNK 26 2 E9PMD8;E9PLG2;P17980;R4GNH3;E9PM69;E9PKD5 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 31994000.0 7775000.0 14017000.0 10202000.0 True False 11795243.428637981 11515556.834679142 8185570.22830455 1.0 0.9762881880606397 0.693972131887553 23.49170185724121 -6.923507377472021 0.7982830249751814 1.0054774256815708 0.6445590040928552 0.99510101640782 0.009729790864101908 0.09615183732899847 0.09524096635790398 0.008542866212597222 0.02651483730086875 1.1925940067827414e-07 6.923507377472021 -0.3609184215887157 QTYSTEPNNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTYSTEPNNLK 11 0 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 17054700.0 4249600.0 1611100.0 11194000.0 False True 4114698.7741134376 2254420.6317755072 8261955.58719831 1.0 0.5478944524344312 2.007912617850975 21.972355388063555 -6.823559951580311 1.3565677335848587 0.7571562426410822 2.0422387422638093 0.8923297806163936 0.2002509949421199 0.18890610029056448 0.6821243687780739 0.11597428979294562 0.2670601599945522 1.5012051596626828e-07 6.823559951580311 1.2850824996227272 up QTYSTEPNNLK(ub)AR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QTYSTEPNNLKAR 13 1 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 1 57354200.0 5681300.0 9392900.0 42280000.0 True False 5500950.2412863895 13143533.953326404 31205599.627188157 1.0 2.3893206404013587 5.67276529661733 22.39124942250301 -6.956654786611695 0.4802640823026647 0.9213836197264507 7.277658708143844 0.9996253043192145 0.03792422307919955 0.08091847618893516 0.025716578442630773 0.0463204519724385 0.2708538542726603 1.1049565823430841e-07 6.956654786611695 6.356275088417393 QTYSTEPNNLK(ub)AR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QTYSTEPNNLKAR 13 1 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 1 53859100.0 7105400.0 9269700.0 37484000.0 True False 10779411.274320805 7615449.610503322 30075270.9701792 1.0 0.7064810328413006 2.7900661923741468 23.36177505057548 -6.8712225650060015 1.1275546856862613 0.8326885213398882 2.914988739237269 0.9658908825520749 0.1700701026304052 0.13569079107922 0.3216742163951978 0.11696383396480882 0.2775310103715242 1.3451708111544333e-07 6.8712225650060015 2.0823002178973806 up QTYSTEPNNLK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QTYSTEPNNLKAR 13 1 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 1 44412770.0 5681300.0 11750000.0 26981470.0 True False 4724252.6742645595 11686700.417807596 32623170.62877806 1.0 2.47376701112349 6.905466933742408 22.171654697937285 -6.95139780530818 0.5432811515208523 0.9361253021967139 8.648918785433585 0.9993064628613553 0.06609268570510134 0.08292926029691192 0.033676633013736045 0.07237125987861003 0.3672053271801819 1.1184129695860041e-07 6.95139780530818 7.712793483236871 QTYSTEPNNLK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QTYSTEPNNLKAR 13 1 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 1 73131200.0 7105400.0 10292000.0 55733800.0 True False 9198080.368373342 9719241.152604882 45590820.27708028 1.0 1.0566597337009034 4.956558156834512 23.13290137266793 -6.91006137000292 0.895300252244019 0.8794851910998727 5.461244811371934 0.9909450819162782 0.17622462873332517 0.1043779033384199 0.13854106298418611 0.1443211809170634 0.3985698289767381 1.2300949342408812e-07 6.91006137000292 4.581759620272061 up QVADQMWQAGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVADQMWQAGKR 12 1 D6RFI3;E7EQR8;Q9GZM5;D6RGY8 D6RFI3 YIPF3 Protein YIPF3;Protein YIPF3, 36 kDa form III 1 9200700.0 1943400.0 1500500.0 5756800.0 True False 2661927.4984102654 1434202.9485100445 4397162.405017643 1.0 0.5387836255369718 1.6518715884048984 21.34403984714483 -6.794171731850241 1.4796088354668318 0.7436191346880091 1.6651120191155513 0.8145697370530383 0.1966334708555449 0.22918342227558475 0.9910464650186688 0.10458074079002762 0.24412796822966176 1.6063059503515268e-07 6.794171731850241 0.9214928844275422 QVAEAYEVLSDAK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVAEAYEVLSDAKK 14 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 163958200.0 44301700.0 53076000.0 66580500.0 True False 58079957.7182731 45157267.68862755 59691388.54525368 1.0 0.7775017314521938 1.0277450413238436 25.791537067275573 -6.672123317634213 1.9298069781036076 0.8582450461990161 1.0267459374437644 0.2886130582735449 0.09446541867497846 0.4561924052770722 3.277366219247788 0.03937957884549021 0.10492341820473945 2.1275348480767517e-07 6.672123317634213 0.16850089124474832 QVAEAYEVLSDAK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVAEAYEVLSDAKK 14 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 27890900.0 5689900.0 11782000.0 10419000.0 True False 5509277.238993798 16486614.042318307 7689951.336699939 1.0 2.9925184969143763 1.3958185444492923 22.3934316336535 -6.5909558639431784 2.2244141631188805 2.3477722508093253 1.4004433676696226 0.0 0.8632165842959593 0.6669782916675947 6.222723947563317 0.32371392388912734 0.9623562411687027 2.564744670648369e-07 6.5909558639431784 -0.9473288831397026 QVAEAYEVLSDAK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVAEAYEVLSDAKK 14 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 358978000.0 160877000.0 165822000.0 32279000.0 True False 244062170.68411508 136229768.5268005 25899041.50161171 1.0 0.558176501278111 0.10611657443271835 27.86267345570987 -7.778970406912418 0.45517176083801564 1.0313395404356003 5.763060385475856e-20 0.9966550476459343 0.021106183191024714 0.11319208442740482 0.08649015358211444 0.031924185050095935 0.07741741734666238 1.6635260001718947e-08 7.778970406912418 -1.0313395404356003 down QVAEAYEVLSDAK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVAEAYEVLSDAKK 14 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 132050900.0 44301700.0 10759000.0 76990200.0 True False 60681235.69842654 10283631.80474482 58806700.422941394 1.0 0.16946971640215747 0.9691084854500788 25.854747128798465 -9.015460784390243 11.889582934926805 1.0000258224689034 0.56928910092697 0.27893230307788397 0.3264511607930187 0.0 0.0 0.31608497712147127 0.1053616590404904 9.650264471332803e-10 9.015460784390243 -0.4307367215419333 QVAEAYEVLSDAK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVAEAYEVLSDAKK 14 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 72461800.0 5689900.0 56029900.0 10742000.0 True False 4731403.955309164 55728055.80763565 12988102.534603717 1.0 11.77833394358614 2.745084261940817 22.173836909087775 -6.602842343393703 2.1802490867182582 8.235400946897855 2.775414696800994 0.028696999350036556 4.6553976396769645 0.6327065703172322 5.688286223011244 1.7698323669469167 5.175040303854267 2.495500473502657e-07 6.602842343393703 -5.459986250096861 QVAEAYEVLSDAK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVAEAYEVLSDAKK 14 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 364233000.0 160877000.0 166417000.0 36939000.0 True False 208258447.85976872 157155747.6576998 30216481.026146967 1.0 0.7546188367039063 0.14509126201926417 27.63379977780232 -7.177272914897447 0.5860223310584569 1.0029786841403638 1.135959703518257e-28 0.9983676658199966 0.014521092470770828 0.08471775036737887 0.049346826814326845 0.014505423336676022 0.05072595593985651 6.648552233779493e-08 7.177272914897447 -1.0029786841403638 down QVAEAYEVLSDAKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVAEAYEVLSDAKK 14 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;Q8WWF6;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3 1 212489000.0 39723000.0 75835000.0 96931000.0 True False 38462015.10827089 106116310.97430067 71541863.23233154 1.0 2.758989893680359 1.8600653925942416 25.19693101478719 -10.11631409207609 6.154531985288206 0.9999952308662233 2.3095276431373146 0.7388746102369271 0.3669843908245389 2.4015189347382137e-05 3.4490344936787127e-06 0.35533240408110633 0.11844370283178532 7.650431094511968e-11 10.11631409207609 1.3095324122710914 QVAIVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVAIVFR 7 0 Q2TAM5;E9PKH5;A0A087X0W8;Q04206-2;Q04206-3;Q04206-4;Q04206 Q2TAM5 RELA Transcription factor p65 0 8119900.0 2718700.0 2335900.0 3065300.0 False True 3564242.02792825 1987392.8252668867 2748132.1604338493 1.0 0.557591995631699 0.7710284932673968 21.765163874937205 -10.109595853634167 4.9868646269529116 1.0000121790378675 0.6643102444483546 0.767344696431562 0.08713508528650422 1.1799208879861068e-05 2.106692608315372e-06 0.0843712431645445 0.028122727848157936 7.769698139673735e-11 10.109595853634167 -0.3357019345895129 QVAIVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVAIVFR 7 0 Q2TAM5;E9PKH5;A0A087X0W8;Q04206-2;Q04206-3;Q04206-4;Q04206 Q2TAM5 RELA Transcription factor p65 0 5604500.0 1869200.0 1275400.0 2459900.0 False True 1809863.2691483486 1784673.8711231367 1815578.394581839 1.0 0.9860821541303145 1.003157766407503 20.787449278581427 -6.689955083963417 1.8663297032553359 0.9912742436088746 1.0030991486241179 0.37035278254093285 0.005886288017873783 0.41675012384302307 2.814334277842921 0.0025230049063624145 0.006571040007934547 2.041949118245284e-07 6.689955083963417 0.011824905015243248 QVAIVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVAIVFR 7 0 Q2TAM5;E9PKH5;A0A087X0W8;Q04206-2;Q04206-3;Q04206-4;Q04206 Q2TAM5 RELA Transcription factor p65 0 10079200.0 2718700.0 2778800.0 4581700.0 False True 3723876.8601049636 2656023.4277372295 3499596.8230734672 1.0 0.7132414758908986 0.9397724346273967 21.828373936460096 -9.887291263195555 5.803644629775789 1.0000000604666965 0.8265069558405771 0.43885601682621966 0.09248087664210417 7.23344937123234e-08 1.4024487757811481e-08 0.08954425445818323 0.029848074589679197 1.2963095986084618e-10 9.887291263195555 -0.17349310462611944 QVAIVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVAIVFR 7 0 Q2TAM5;E9PKH5;A0A087X0W8;Q04206-2;Q04206-3;Q04206-4;Q04206 Q2TAM5 RELA Transcription factor p65 0 4001470.0 1869200.0 853070.0 1279200.0 False True 1554322.619600322 848474.3425888624 1546674.8056474666 1.0 0.5458804574349171 0.9950796482941089 20.567854554015703 -10.945728561911489 10.578174991218669 1.0611966524289154 0.7704800528645135 0.25821423069106664 0.18338480174601557 0.10430619141111812 0.0005351433893136753 0.06997702721976409 0.059187190259155614 1.1331083452142986e-11 10.945728561911489 -0.2907165995644019 QVAPEKPVK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVAPEKPVKK 10 2 P53999;D6RC37;D6R970 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 1 6174200.0 2474900.0 2644500.0 1054800.0 True False 2396335.6541917687 3700462.6408853168 778516.2366782886 1.0 1.5442171610693667 0.3248777921892853 21.19239856957198 -6.785365348615247 1.5147109574115045 1.3060069577395461 0.3134998108509455 0.7859798757858938 0.23073258361784618 0.24233503970026976 1.0984046483136036 0.11993180970866713 0.2817773699987013 1.63921021351976e-07 6.785365348615247 -0.9925071468886006 down QVAPEKPVK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVAPEKPVKK 10 2 P53999;D6RC37;D6R970 P53999 SUB1 Activated RNA polymerase II transcriptional coactivator p15 1 5695650.0 2474900.0 2830330.0 390420.0 True False 2057989.0066599844 2815082.45051348 472055.016901879 1.0 1.3678802177287728 0.2293768408743841 20.972803845006258 -6.819717549712708 1.3730042839995917 1.1983478318556522 0.20465542069798642 0.8837420601671452 0.1617498705765202 0.19385620709696386 0.7181443756391216 0.09257528463540757 0.21339692129308674 1.5145459371094475e-07 6.819717549712708 -0.9936924111576657 down QVASHVGLHSASIPGILALDLCPSDTNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVASHVGLHSASIPGILALDLCPSDTNK 28 0 Q9UMS4;F5GY56 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 37741200.0 25346700.0 9103100.0 3291400.0 False True 33229769.157792 7744952.96360588 2950837.5013382006 1.0 0.23307272845709123 0.08880102318274044 24.98597293509085 -13.999999999999998 0.23493353718123208 5.954555558188718 0.021868454039040253 0.9995169141557828 0.008789471244958005 13.449973205539226 0.15343708827334004 31.17188474739366 0.07265806830966588 1.0000000000000041e-14 13.999999999999998 -5.932687104149678 QVASHVGLHSASIPGILALDLCPSDTNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVASHVGLHSASIPGILALDLCPSDTNK 28 0 Q9UMS4;F5GY56 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 58931000.0 22250000.0 20246000.0 16435000.0 False True 21543685.929034226 28330333.381495234 12130180.460568538 1.0 1.3150179349446747 0.5630503758978777 24.360761767232475 -6.792918460612374 1.4847529795949268 1.1753965139090896 0.5544083955832326 0.8106174578131407 0.13418015438702974 0.2310251559953652 1.0060486053224413 0.07112355602564323 0.16616342996585945 1.610948064506325e-07 6.792918460612374 -0.620988118325857 QVASHVGLHSASIPGILALDLCPSDTNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVASHVGLHSASIPGILALDLCPSDTNK 28 0 Q9UMS4;F5GY56 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 471662000.0 100333000.0 211067000.0 160262000.0 False True 152212496.32482776 173400444.77600187 128586145.45467019 1.0 1.1391997960926818 0.8447804783403725 27.181511565021776 -6.778137502442794 1.5431252249294576 1.0790089351892032 0.8425828711356996 0.7607466656580474 0.058821197713092806 0.25347812850174023 1.192077771948984 0.030026733401896783 0.07096164559309244 1.6667194271745162e-07 6.778137502442794 -0.23642606405350353 QVASHVGLHSASIPGILALDLCPSDTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVASHVGLHSASIPGILALDLCPSDTNK 28 0 Q9UMS4;F5GY56 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 89472100.0 25346700.0 16012000.0 48113400.0 False True 34718059.95881216 15304536.895396758 36750005.84657723 1.0 0.44082350550558774 1.058527057392483 25.04918299661374 -6.668286625507212 1.9431868279818216 0.6425651273027866 1.0560280331631642 0.27162075125893226 0.23761830273771545 0.46504382960023544 3.3836501299800537 0.09849644058705354 0.2637721119866199 2.146413417455707e-07 6.668286625507212 0.4134629058603776 QVASHVGLHSASIPGILALDLCPSDTNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVASHVGLHSASIPGILALDLCPSDTNK 28 0 Q9UMS4;F5GY56 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 67395900.0 22250000.0 10898100.0 34247800.0 False True 18501860.842128813 10839389.772196515 41408856.63606412 1.0 0.5858540319098704 2.2380914541188193 24.14116704266675 -6.8403044647383595 1.2808469051472684 0.7796779308332239 2.292806015954444 0.9249902298837381 0.1922423269491851 0.168449867469155 0.5366671688697793 0.11767855195943212 0.27115123077352926 1.4444267916874174e-07 6.8403044647383595 1.5131280851212203 up QVASHVGLHSASIPGILALDLCPSDTNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVASHVGLHSASIPGILALDLCPSDTNK 28 0 Q9UMS4;F5GY56 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 128470000.0 100333000.0 15407000.0 12730000.0 False True 129883046.35910773 14549586.906158531 10413270.620830296 1.0 0.11202067794076095 0.08017420989679529 26.952637887114225 QVATALQNLQTK(ub)TNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVATALQNLQTKTNR 15 1 P18206;P18206-2 P18206 VCL Vinculin 1 12234100.0 3442400.0 6063400.0 2728300.0 True False 4513019.736249023 5158764.354948089 2446001.6877015866 1.0 1.143084820461205 0.5419878109672461 22.105661657053908 -6.843898145152472 1.2641280252265352 1.0761237902803018 0.5206364287044795 0.9309577479687359 0.06736554655164799 0.16429373208461498 0.5082960468464325 0.04175666705211343 0.09632620851152275 1.432523828910124e-07 6.843898145152472 -0.5554873615758223 QVATALQNLQTK(ub)TNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVATALQNLQTKTNR 15 1 P18206;P18206-2 P18206 VCL Vinculin 1 13157400.0 4391400.0 3410500.0 5355500.0 True False 4251997.410730832 4772330.435522551 3952733.888443855 1.0 1.1223737868415784 0.9296181315793558 22.019709287659108 -6.735195376107935 1.7045295165992258 1.0732164827724515 0.9296251512777227 0.5830467281984228 0.051425493783750845 0.3265958318686674 1.8612463779674664 0.023887481604527975 0.05892424592517268 1.8399440794020958e-07 6.735195376107935 -0.1435913314947288 QVATALQNLQTK(ub)TNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVATALQNLQTKTNR 15 1 P18206;P18206-2 P18206 VCL Vinculin 1 12165300.0 3442400.0 4483300.0 4239600.0 True False 4715148.307362099 4285212.9817094905 3238293.7973028054 1.0 0.9088182814989467 0.6867851414655665 22.1688717185768 -6.956023224251323 0.4882649213019961 1.0049363073302084 0.5812795700066808 0.99959309203309 0.0026533402661474415 0.08115351675882475 0.026622234962330724 0.0031849450807654987 0.01831273183989305 1.1065646079512953e-07 6.956023224251323 -0.4236567373235276 QVATALQNLQTK(ub)TNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVATALQNLQTKTNR 15 1 P18206;P18206-2 P18206 VCL Vinculin 1 11522900.0 4391400.0 4461200.0 2670300.0 True False 3651643.6720055994 4437166.630121132 3228647.3839277914 1.0 1.2151148985695253 0.8841627699546366 21.800114563093384 -6.731279307758374 1.7184893213148515 1.1292725957192449 0.884311631751762 0.5651667403724714 0.09042083797895784 0.3338725353956403 1.9322159978436348 0.04168575397216522 0.10329389399369657 1.8566100296604766e-07 6.731279307758374 -0.2449609639674829 QVCPVCK(ub)AGISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVCPVCKAGISR 12 1 A9X3U0;Q96GF1 A9X3U0 RNF185 E3 ubiquitin-protein ligase RNF185 1 16082200.0 5141800.0 6805100.0 4135300.0 True False 6740949.593262038 5789805.606072036 3707418.8245986053 1.0 0.8589005934504057 0.5499846532459434 22.684520406575793 -6.958237785385883 0.45959565343295233 1.0090407963133927 0.3873998848124148 0.9996991548497888 0.0032595825668018685 0.08033671943751032 0.02350337170418526 0.004192552145817625 0.025520697216099158 1.1009363586228655e-07 6.958237785385883 -0.621640911500978 QVCPVCK(ub)AGISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVCPVCKAGISR 12 1 A9X3U0;Q96GF1 A9X3U0 RNF185 E3 ubiquitin-protein ligase RNF185 1 17725600.0 8460300.0 4121900.0 5143400.0 True False 10952025.1274452 3892512.641558696 4207353.975740662 1.0 0.3554148749900385 0.38416219162949633 23.3846943259272 -10.698399717685929 6.735059135148344 1.005863953918552 0.3697885333098112 0.9984418610898762 0.011736042873482028 0.0010344177539323867 4.632184708727399e-05 0.011374904874468994 0.003787791549947678 2.002627992153156e-11 10.698399717685929 -0.6360754206087409 QVDGDNSHVEMK(ub)LAVDEEENADNNTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVDGDNSHVEMKLAVDEEENADNNTK 26 1 P02786;F8WBE5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 1 53723600.0 23304000.0 25034000.0 5385600.0 True False 30551769.67625704 21299024.78176771 4828349.774323088 1.0 0.6971453702179486 0.1580383010701794 24.86475261313331 -7.295854537665188 0.5099397104644717 1.0100686938681571 2.6689499451906284e-24 0.998440090336046 0.013752825262018478 0.0994981395183273 0.04923889471557143 0.014928744746427186 0.05619804554774203 5.059941109897843e-08 7.295854537665188 -1.0100686938681571 down QVDGDNSHVEMK(ub)LAVDEEENADNNTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVDGDNSHVEMKLAVDEEENADNNTK 26 1 P02786;F8WBE5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 1 41744000.0 10225000.0 13916000.0 17603000.0 True False 9900412.971882034 19472731.37098131 12992246.221319607 1.0 1.9668605164537507 1.312293361723256 23.239057274320466 -10.495097659089371 5.121834697764541 0.9983409232874824 1.6395769390885158 0.5600457056898713 0.2672259219125629 0.005073758020685784 0.0005001626682530314 0.25931142385812317 0.0862467954368504 3.1981758602547066e-11 10.495097659089371 0.6412360158010334 QVDGDNSHVEMK(ub)LAVDEEENADNNTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVDGDNSHVEMKLAVDEEENADNNTK 26 1 P02786;F8WBE5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 1 91230800.0 46909800.0 30475000.0 13846000.0 True False 71165596.16575204 25036498.147738237 11109332.031082619 1.0 0.351806202668852 0.1561053743610583 26.08467662679995 -13.1764521990005 0.1806659150650817 3.4721022430102453 1.2765418274315143e-19 0.9994734942201261 0.008275356751790527 8.906947574794554 0.12964374352043176 7.909244270631747 0.1437621168528812 6.661128335515556e-14 13.1764521990005 -3.4721022430102453 QVDGDNSHVEMK(ub)LAVDEEENADNNTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVDGDNSHVEMKLAVDEEENADNNTK 26 1 P02786;F8WBE5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 1 52248000.0 23304000.0 17614000.0 11330000.0 True False 31920118.56692028 16835755.238291215 8654087.348674579 1.0 0.5274339818943713 0.2711170176430063 24.9279626746562 -9.175057294108948 0.19494881460310579 1.4401225820895043 3.03057499421089e-13 0.9995833418137471 0.006162423519909431 0.6121510184756411 0.06860235801811274 0.30949046679946096 0.14396925669799338 6.682557524062756e-10 9.175057294108948 -1.4401225820892012 QVDGDNSHVEMK(ub)LAVDEEENADNNTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVDGDNSHVEMKLAVDEEENADNNTK 26 1 P02786;F8WBE5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 1 46588100.0 10225000.0 27807000.0 8556100.0 True False 8502540.544304153 27657198.17174264 10345140.95106339 1.0 3.252815794012318 1.2167117459961534 23.019462549754742 -6.6219638272805605 2.1097139810333454 2.4926992599930546 1.2245739947031953 0.08950670667597116 0.9682932757512571 0.5800322423397264 4.908515787232566 0.37678939136754525 1.0733443615133025 2.388010173823316e-07 6.6219638272805605 -1.2681252652898594 QVDGDNSHVEMK(ub)LAVDEEENADNNTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVDGDNSHVEMKLAVDEEENADNNTK 26 1 P02786;F8WBE5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 1 86156800.0 46909800.0 26594000.0 12653000.0 True False 60725660.83039944 25114020.521995172 10350283.830743598 1.0 0.41356520750158754 0.17044332970950918 25.8558029488924 -9.96320501424954 0.22314735673115246 1.5863188420914034 6.83297714878257e-21 0.9992632844157727 0.009450971414718925 1.4464384395184666 0.10093264150569436 0.648928828427031 0.12417550273128063 1.0884161713050106e-10 9.96320501424954 -1.5863188420914034 QVDMDHVMK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVDMDHVMKAK 11 1 J3KTE1;Q8WU67;J3KSP1 J3KTE1 ABHD3 Phospholipase ABHD3 1 50145400.0 1978400.0 11895000.0 36272000.0 True False 3001377.440413812 9772244.313940808 29102823.30141764 1.0 3.2559198261293885 9.696488988537581 21.51719332683846 -6.952559165187718 0.5300050022636117 0.8984261420441666 12.346361251055932 0.9993871118271981 0.09122276612798798 0.08247411533362844 0.03183332828303767 0.10177182445459187 0.5326009613320626 1.11542618327901e-07 6.952559165187718 11.447935109011764 QVDNGEK(ub)FEFSGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVDNGEKFEFSGLR 14 1 P55160;P55160-2 P55160 NCKAP1L Nck-associated protein 1-like 1 13518600.0 2426100.0 3960200.0 7132300.0 True False 3680571.0716679906 3253471.3688161727 5722597.778801855 1.0 0.8839583057804501 1.5548124645256318 21.811498199286884 -6.86230899969509 1.174101069310542 0.9366185854966119 1.588747106497842 0.9563808401728434 0.06114161375182888 0.14443705199624654 0.3770540027855724 0.040578334922127424 0.09497621999747438 1.373064694477287e-07 6.86230899969509 0.6521285210012301 QVDVPTLTGAFGILAAHVPTLQVLRPGLVVVHAEDGTTSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVDVPTLTGAFGILAAHVPTLQVLRPGLVVVHAEDGTTSK 40 1 P30049 P30049 ATP5D ATP synthase subunit delta, mitochondrial 0 14876555000.0 5489783000.0 3878770300.0 5508001700.0 False True 8328402167.896934 3186573434.9943233 4419342749.752091 1.0 0.3826152208736323 0.5306351279225091 32.955392590205435 -10.21820582173394 8.220011461570712 1.0000002035834197 0.4566251743987958 0.9472793720730226 0.06042887400732386 2.2547112235759268e-07 2.1425428790034564e-08 0.05851002746091087 0.01950333522170264 6.050540583314184e-11 10.21820582173394 -0.5433750291846239 QVDVPTLTGAFGILAAHVPTLQVLRPGLVVVHAEDGTTSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVDVPTLTGAFGILAAHVPTLQVLRPGLVVVHAEDGTTSK 40 1 P30049 P30049 ATP5D ATP synthase subunit delta, mitochondrial 0 13633943000.0 5489783000.0 3754650000.0 4389510000.0 False True 7106632313.301097 3545700426.897391 3590664220.1760263 1.0 0.4989283630533546 0.5052553814351104 32.72651891229788 -9.847443645539244 6.592428228745941 1.0000000125604225 0.5020918722446127 0.9998789093523257 0.002582994438219816 4.768439463168302e-10 8.479594503806801e-11 0.002500973647850655 0.0008336578701944455 1.420876575180221e-10 9.847443645539244 -0.49790814031580977 QVEDDIQQLLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVEDDIQQLLKK 12 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 17906600.0 4517100.0 7477200.0 5912300.0 True False 4373707.133035534 10462884.953082897 4363691.264801899 1.0 2.392223492527544 0.9977099819606157 22.06042518891845 -6.6465321931546875 2.020766884399616 1.905865735400243 1.003538923293643 0.1802000303593968 0.5947221593624955 0.5170561519257031 4.042937402204773 0.2390050736961787 0.6587062011273138 2.2566687081368114e-07 6.6465321931546875 -0.9023268121066002 QVEDDIQQLLK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVEDDIQQLLKK 12 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 14988700.0 4517100.0 6362000.0 4109600.0 True False 3756168.7914597834 6327726.643241874 4968898.359356495 1.0 1.6846225488132789 1.3228634375148516 21.840830464352727 -10.047590252865945 4.328868895498392 0.9999628762457465 1.5037429930743482 0.7210864929534537 0.14768753902956192 25567458.7737588 0.7942449595733124 9674.490560762857 0.050557372826354294 8.962099208178737e-11 10.047590252865945 0.5037801168286017 QVEDDIQQLLK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVEDDIQQLLKK 12 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 50233900.0 7796900.0 17247000.0 25190000.0 True False 10093240.749876177 16287189.288668538 20605678.471226636 1.0 1.613672921540918 2.0415324455110637 23.266886135296147 -7.742986266947829 0.11305606437894923 1.1064169725533859e-19 3.3357746591615545 0.9999905939561871 0.0013109559922057056 0.13699394842428275 0.014329824871709347 0.17254693894861073 0.22791215568547496 1.807231272509407e-08 7.742986266947829 3.3357746591615545 QVEPLDPPAGSAPGEHVFVK(ub)GYEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVEPLDPPAGSAPGEHVFVKGYEK 24 1 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 1 7286100.0 2062700.0 3577000.0 1646400.0 True False 1715226.4431037824 3557729.9910210897 1990654.6279064957 1.0 2.074204257592491 1.160578322419233 20.709967621977263 -10.275972688300497 4.2364048605136855 0.9994719370018882 1.61739129002307 0.3784448302175648 0.3729862262157026 38373287.771372475 93081149.90117918 115880.41539368869 0.12768308876664997 5.296967541553046e-11 10.275972688300497 0.6179193530211818 QVFK(ub)ELEFLGWYTTGGPPDPSDIHVHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVFKELEFLGWYTTGGPPDPSDIHVHK 27 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 32568100.0 4799100.0 13979000.0 13790000.0 True False 7280585.561205986 11484338.231574493 11064400.455628287 1.0 1.5773921115312297 1.5197129904748397 22.795623057148553 -10.162958954038405 4.931812623935563 0.9999591605071099 1.548552551004423 0.9917761395014472 0.023547402571547464 1.057479001340027e-05 1.7947934960534557e-06 0.02280136693635677 0.007599891499815913 6.87133379171189e-11 10.162958954038405 0.548593390497313 QVFK(ub)ELEFLGWYTTGGPPDPSDIHVHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVFKELEFLGWYTTGGPPDPSDIHVHK 27 1 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 28775400.0 4799100.0 15726000.0 8250300.0 True False 6212529.554403769 14850834.275735002 6748830.055226727 1.0 2.390464970135707 1.086325625677354 22.566749379241003 -6.631115821950067 2.077051347338276 1.915353277086846 1.0916630280252775 0.12129552335493754 0.5962765616660606 0.5561048354585627 4.573661890301633 0.23471861831097787 0.6602481559861851 2.3382135775659475e-07 6.631115821950067 -0.8236902490615685 QVGSISMDLQLTNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVGSISMDLQLTNK 14 0 Q10567-3;Q10567-2;Q10567 Q10567-3 AP1B1 AP-1 complex subunit beta-1 0 21730400.0 8050800.0 7843600.0 5836000.0 False True 12213652.192318797 6443848.297673487 4682512.041990327 1.0 0.5275938921632337 0.383383444055757 23.541991331521764 -13.999999999999998 0.16621372778883267 3.3596727327731672 0.250906751671651 0.9995214181983841 0.005761182037179969 12.056929921540513 0.12902002627613776 9.170856354360286 0.12175324108559289 1.0000000000000041e-14 13.999999999999998 -3.1087659811015165 QVGVGYVDSIQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVGVGYVDSIQR 12 0 A0A2R8YFH0;E9PHA6;A0A2R8Y6P0;A0A2R8YG02;P43246;P43246-2;A0A2R8Y7S8 A0A2R8YFH0 MSH2 DNA mismatch repair protein Msh2 0 7749300.0 1218500.0 3736700.0 2794100.0 False True 1597465.299970786 3179198.92554252 2504993.3348997566 1.0 1.9901521025844255 1.5681050066912672 20.6073531627163 -10.216245490551755 4.756257892655598 0.9998541623620524 1.7791285546405073 0.8196237382921268 0.1723000054027733 0.00026650359886524284 4.391517903051798e-05 0.16685955277266573 0.05560958762173365 6.07791342271453e-11 10.216245490551755 0.779274392278455 QVHPDTGISSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVHPDTGISSK 11 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 653935000.0 15695000.0 350780000.0 287460000.0 False True 20576296.990596227 298444991.3297308 257716396.7110282 1.0 14.504310054725885 12.524916258197948 24.29448003546244 -9.398326307356214 12.132146456765446 0.9999580998135026 13.514613156461916 0.9815830435156062 0.808084133949402 0.0 0.0 0.7824240981165067 0.2608080327055022 3.996443639533662e-10 9.398326307356214 12.514655056648413 QVHPDTGISSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVHPDTGISSK 11 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 491876000.0 172160000.0 58726000.0 260990000.0 False True 166694875.0356196 82175598.05204436 192628889.46782935 1.0 0.4929701530085131 1.1555777550249708 27.312634509047978 -6.702249151627144 1.8230058755883543 0.685843486441576 1.1536799935473647 0.4281464248112167 0.21393787700722164 0.390883846160192 2.527096165215936 0.09357117074946475 0.2399604977130921 1.9849558357310856e-07 6.702249151627144 0.4678365071057887 QVHPDTGISSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVHPDTGISSK 11 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 1853668000.0 13012000.0 1828400000.0 12256000.0 False True 19740155.304622203 1502107734.6455975 9833596.228004383 1.0 76.09401807967922 0.4981519180703621 24.234630004377017 -13.948143310945845 4.834989747184003e-12 9.540784448987035 59.592141192798145 0.0 36.56909022605243 0.0 0.27134203082170116 3290681326.5880547 3290681469.018424 1.126825558556813e-14 13.948143310945845 50.05135674381111 QVHPDTGISSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVHPDTGISSK 11 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 657625000.0 15695000.0 354340000.0 287590000.0 False True 21497865.641426966 338684087.1543153 219667165.10197055 1.0 15.754312209564747 10.21809182203958 24.35769009698533 -9.547253386618433 11.303908494005418 1.000000004540433 12.986202015802164 0.8620676416469053 2.2601525088383343 0.0 0.0 2.188383256654945 0.7294610855516481 2.8362637438315034e-10 9.547253386618433 11.986202011261732 QVHPDTGISSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVHPDTGISSK 11 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 187852600.0 172160000.0 10041000.0 5651600.0 False True 143158667.98116404 9986907.140017541 6833323.429954041 1.0 0.06976110689526364 0.04773251613973615 27.093039784482254 QVHPDTGISSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVHPDTGISSK 11 0 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 0 39953000.0 13012000.0 11570000.0 15371000.0 False True 16844290.5048659 10926119.329152593 12573635.719778677 1.0 0.6486541731155911 0.7464627682683616 24.005756326469466 -10.160086716805859 7.548756587301629 1.000000138146694 0.6975584706919771 0.9272661044518371 0.0399301917637906 9.282368348860409e-08 1.0379370652713457e-08 0.03866225921115661 0.012887413976002465 6.91692844865377e-11 10.160086716805859 -0.302441667454717 QVHPDTGISSK(ub)AMGIMNSFVNDIFER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVHPDTGISSKAMGIMNSFVNDIFER 26 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 22280300.0 7729900.0 9922300.0 4628100.0 True False 10006507.929108724 9370115.282597318 3785833.288316157 1.0 0.9364021243954495 0.37833710972268825 23.25443525453585 -6.928418049866861 0.7596677537761165 1.0090033205490878 0.2682529711083008 0.9962180371148666 0.017174701740023585 0.0934676789825523 0.08176639046223715 0.015502179115220121 0.05094161523555584 1.1791850111084506e-07 6.928418049866861 -0.740750349440787 down QVILTLQPTLVAVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVILTLQPTLVAVGK 15 0 J3QKR4;J3QQX6;J3QRQ1;J3QRT5;P13598;J3QQR8 J3QKR4 ICAM2 Intercellular adhesion molecule 2 0 3510550.0 509920.0 907830.0 2092800.0 False True 698451.2040698588 867719.0688076472 1598523.7425689467 1.0 1.2423474449631822 2.288669177251591 19.41379980251898 -6.94312388795964 0.6298297531806601 0.9885863713098658 2.5988049881129096 0.9985451241326647 0.02132889636405901 0.08636993407502468 0.04833342779667633 0.021291185779041415 0.0888900855137352 1.1399245633667392e-07 6.94312388795964 1.610218616803044 up QVISLQTK(ub)NPEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVISLQTKNPEGR 13 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 5967600.0 2121100.0 1714100.0 2132400.0 True False 2780782.640761619 1458362.961509468 1911759.703425159 1.0 0.5244433491968441 0.6874898006776803 21.407059550488256 -10.210384605442616 6.199527657280567 1.0000050152269033 0.6059665749372614 0.8861982988976091 0.06656343508325373 4.614124264978599e-06 5.876706746684297e-07 0.06445058919879582 0.0214832562953162 6.16049195207503e-11 10.210384605442616 -0.39403844028964197 QVISLQTK(ub)NPEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVISLQTKNPEGR 13 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 5291660.0 924060.0 1624800.0 2742800.0 True False 894726.221104871 2273591.113220063 2024378.3977637582 1.0 2.5411025848918034 2.262567420080651 19.771086771474735 -10.113923084907734 4.714624024642479 0.9999072425607515 2.4018350024456505 0.9712422376166261 0.11371150493029188 7074466.569809272 15176323.181734327 4269.5261247432445 0.038926472184555326 7.692666680769142e-11 10.113923084907734 1.4019277598848991 QVISLQTK(ub)NPEGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVISLQTKNPEGR 13 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 25944800.0 5567900.0 3626900.0 16750000.0 True False 8446911.368014585 2979651.3579009557 13439355.15821421 1.0 0.35275039929788105 1.5910377856105147 23.009992482480655 -6.7646694757834025 1.5949056907098236 0.626233806639961 1.5966363348723567 0.7097457608723345 0.2724483711685694 0.2751346363752082 1.3803227571024848 0.13471875798121516 0.3222740177366494 1.7192163163882037e-07 6.7646694757834025 0.9704025282323957 QVISLQTK(ub)NPEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVISLQTKNPEGR 13 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 6316700.0 2121100.0 1596400.0 2599200.0 True False 2905327.9905722006 1525865.7694111548 1985322.4922043257 1.0 0.5251957005758368 0.683338507268957 21.470269612011148 -10.287317725358328 5.241195332538788 1.000072793925844 0.6042671039223494 0.893038820604298 0.0645615304817895 5.492633473564762e-05 7.468713653616728e-06 0.06252288229224877 0.020837144363445526 5.160387025543351e-11 10.287317725358328 -0.39580569000349464 QVISLQTK(ub)NPEGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVISLQTKNPEGR 13 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 41006700.0 5567900.0 4553800.0 30885000.0 True False 7207756.309717391 4300377.026888085 25264246.906861257 1.0 0.5966318563087906 3.5051472082651256 22.781118804573104 -6.871823028360966 1.124338985496161 0.7691241195955084 3.68154228080234 0.9664723907968618 0.2355824868298529 0.13512238649096187 0.31812761869879164 0.1624182090007847 0.3858163135410398 1.3433122389619022e-07 6.871823028360966 2.9124181612068316 up QVK(ub)PYVEEGLHPQIIIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVKPYVEEGLHPQIIIR 17 1 Q99832;Q99832-3;Q99832-4;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 1 6520800.0 1591800.0 2934100.0 1994900.0 True False 2086865.2150131261 2496343.71703222 1788486.884432025 1.0 1.1962170336029672 0.8570207944267142 20.992905993055448 -6.749874289464076 1.650481091787093 1.1153956771743583 0.8563599663948924 0.6483687718119007 0.08245080947161605 0.30026015595070826 1.6092793368232374 0.039464947623028795 0.09581644277408333 1.7787942238902992e-07 6.749874289464076 -0.25903571077946586 QVK(ub)PYVEEGLHPQIIIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVKPYVEEGLHPQIIIR 17 1 Q99832;Q99832-3;Q99832-4;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 1 10613800.0 2548300.0 3689600.0 4375900.0 True False 2467405.611368897 5162876.521009825 3229720.5158139197 1.0 2.0924312148846504 1.308954028852231 21.234563465914828 -10.243122456377323 4.959657999735023 0.9998765072527701 1.7006926218689593 0.5160786534672783 0.31985322181731823 0.00043687113716266016 6.666956989162355e-05 0.3097505096665842 0.10323218344379852 5.713175217113063e-11 10.243122456377323 0.7008161146161892 QVK(ub)PYVEEGLHPQIIIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVKPYVEEGLHPQIIIR 17 1 Q99832;Q99832-3;Q99832-4;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 1 8110000.0 2548300.0 3386900.0 2174800.0 True False 2119024.3588313214 3368654.0974529902 2629540.624860936 1.0 1.5897193835519954 1.2409204329822678 21.014968741349104 -10.275547448175915 5.078522463465701 0.9999130662586259 1.4153199082671284 0.6540272216504899 0.14239657528615174 0.00014020488547985546 2.000020483168521e-05 0.13790360954193925 0.045958297053285455 5.3021566156776156e-11 10.275547448175915 0.41540684200850253 QVKPYVEEGLHPQIIIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVKPYVEEGLHPQIIIR 17 1 Q99832;Q99832-3;Q99832-4;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 0 71848000.0 16970000.0 26062000.0 28816000.0 False True 22247834.337713778 22173651.188880347 25834396.742590226 1.0 0.9966656013476476 1.1612095069764443 24.407161571422986 -6.902275872883829 0.9467670302199532 0.9935794811044455 1.1793022252776661 0.9876649784597357 0.008528856814212846 0.10974940552931371 0.16812200294767296 0.006726320204784942 0.01770929609726302 1.2523454063855804e-07 6.902275872883829 0.18572274417322066 QVKPYVEEGLHPQIIIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVKPYVEEGLHPQIIIR 17 1 Q99832;Q99832-3;Q99832-4;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 0 54362000.0 12332000.0 11613000.0 30417000.0 False True 11940527.41019551 16250131.460994966 22449875.20955966 1.0 1.3609224201537085 1.8801410053621805 23.509363225711166 -6.9659426186654105 0.3414878810441362 0.9446451566949199 2.3137123250228337 0.9999312782108322 0.002994690087811026 0.07764252883155565 0.013740087359324783 0.007296633955479701 0.04489200472021781 1.0815768456372065e-07 6.9659426186654105 1.3690671683279139 QVKPYVEEGLHPQIIIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVKPYVEEGLHPQIIIR 17 1 Q99832;Q99832-3;Q99832-4;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 0 146875000.0 10300000.0 117920000.0 18655000.0 False True 15625853.030864457 96876254.68683492 14967831.073223032 1.0 6.199741831404868 0.9578888937236458 23.897431614293826 -6.648123877088058 2.016507630071542 4.379293156321653 0.980418153219234 0.1861046544307371 2.220370558161833 0.5130516186757069 3.9970935347531564 0.8939440458068169 2.457235754152772 2.2484131825243007e-07 6.648123877088058 -3.398875003102419 QVKPYVEEGLHPQIIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVKPYVEEGLHPQIIIR 17 1 Q99832;Q99832-3;Q99832-4;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 0 93374000.0 16970000.0 31757000.0 44647000.0 False True 23244267.597006395 30353870.7336445 34102298.133828275 1.0 1.3058647947055015 1.4671272386409917 24.470371632945877 -11.714300430949205 0.10229830744189423 1.8968931656460173e-21 1.8458220279681483 0.999854759902129 0.002334689353935967 4.93165979487626 0.07149332454551842 1.367428339266066 0.27402455331460784 1.930632305654189e-12 11.714300430949205 1.8458220279681483 QVKPYVEEGLHPQIIIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVKPYVEEGLHPQIIIR 17 1 Q99832;Q99832-3;Q99832-4;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 0 32624600.0 12332000.0 11959000.0 8333600.0 False True 10254604.400230678 11894574.493324356 10076117.229787145 1.0 1.1599252422703685 0.9825944362671349 23.289768501145442 -6.669140555573697 1.9402990916660163 1.1021577688059148 0.9833132788159226 0.2751712509218648 0.06794686671593851 0.4631730587796246 3.3608975489382176 0.028199384156103457 0.07542952211669442 2.1421971857163864e-07 6.669140555573697 -0.1188444899899922 QVKPYVEEGLHPQIIIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVKPYVEEGLHPQIIIR 17 1 Q99832;Q99832-3;Q99832-4;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 0 44219000.0 10300000.0 23049000.0 10870000.0 False True 13333553.043353708 21766302.888300654 8891771.535618642 1.0 1.6324458167697742 0.6668718762888837 23.668557936386275 -6.73000660509225 1.7233858433310913 1.3806022371094901 0.667463828789442 0.5592343672508111 0.26586439202440537 0.3362168889555663 1.956357880479468 0.12225658369570117 0.3033482976543148 1.8620588167916765e-07 6.73000660509225 -0.7131384083200482 QVLDSK(ub)APKPEDIDEEDDDVPDLVENFDEASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVLDSKAPKPEDIDEEDDDVPDLVENFDEASK 32 2 Q96K17;Q96K17-2 Q96K17 BTF3L4 Transcription factor BTF3 homolog 4 1 9812600.0 4641400.0 3067800.0 2103400.0 True False 4494061.297573912 4292788.538365653 1552456.43935259 1.0 0.9552136150619674 0.34544620924300096 22.09958837188 -6.921653848651386 0.8123734332446695 1.0126692289835861 0.2432776600164993 0.9946279359851482 0.021883039304431615 0.09720859662522506 0.10064570759122834 0.019021441204599573 0.05791050514997723 1.197694765125181e-07 6.921653848651386 -0.7693915689670868 down QVLGQMVIDEELLGDGHSYSPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVLGQMVIDEELLGDGHSYSPR 22 0 P28070 P28070 PSMB4 Proteasome subunit beta type-4 0 16533100.0 6490800.0 2295100.0 7747200.0 False True 6284753.106884286 3211545.3987883893 5717975.908981841 1.0 0.511005817439428 0.9098171100338691 22.583424639591282 -9.980124253787833 6.972161780846346 1.0000000224410242 0.7104114637366487 0.4128072176278823 0.16281402841936593 5.6960929683292125e-08 8.086143377468148e-09 0.15764401924373783 0.052548001716428545 1.0468290022746381e-10 9.980124253787833 -0.2895885587043755 QVLK(ub)YDDFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVLKYDDFLK 10 1 Q07960;H0YE29 Q07960 ARHGAP1 Rho GTPase-activating protein 1 1 5508700.0 1278300.0 1904000.0 2326400.0 True False 1237721.0662060445 2664277.1292288294 1717046.0494959916 1.0 2.152566682407347 1.3872641392128922 20.239254793616006 -10.12071148347 4.825901044888191 0.9999560384106534 1.7699154108154354 0.5743693985494908 0.31243345496510805 217926659.00278687 9.475670070253017 106460.66807545895 0.10695428187452521 7.573358517874085e-11 10.12071148347 0.769959372404782 QVLK(ub)YDDFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVLKYDDFLK 10 1 Q07960;H0YE29 Q07960 ARHGAP1 Rho GTPase-activating protein 1 1 4749900.0 1278300.0 1851500.0 1620100.0 True False 1062963.0882918336 1841525.6020060265 1958855.4195039566 1.0 1.7324454840340051 1.8428254387006129 20.019660069050282 -11.18915128481588 0.3392122076470474 1.5025395432425746e-10 1.8635854845327486 0.9993975355555128 0.009180361753483354 3.20976748747247 0.17247737885202352 2.4716523559055457 0.03411652565120884 6.469172253614402e-12 11.18915128481588 1.8635854843824946 QVLLSAAEAAEVILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVLLSAAEAAEVILR 15 0 P78371;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 0 23194300.0 0.0 16995000.0 6199300.0 False True 0.0 13962109.467458935 4974005.637750285 0.0 QVLQLQASHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVLQLQASHR 10 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 37437000.0 13749000.0 9646000.0 14042000.0 False True 18025072.145505413 8206854.399813505 12589068.54037522 1.0 0.45530216653584377 0.6984198697653662 24.10350169808843 -10.359440305704574 5.895471712734388 1.00007080786157 0.5768610181506073 0.8015471155972116 0.09925238672495544 9.238788451930742e-05 1.0038048865679682e-05 0.0961167021285018 0.03203357007142389 4.370787519386442e-11 10.359440305704574 -0.4232097897109628 QVLQLQASHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVLQLQASHR 10 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 20972400.0 5985800.0 1884600.0 13102000.0 False True 5795784.055461267 2637130.608059169 9670193.148425248 1.0 0.4550084307530827 1.6684874826061182 22.46657241199008 -6.784612515350243 1.517863528650082 0.6932603361534105 1.6795349687641157 0.7833851513796772 0.23096658604426026 0.24347139712441715 1.1081665715639457 0.11981476230699752 0.28164686969207575 1.6420541874552983e-07 6.784612515350243 0.9862746326107051 QVLQLQASHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVLQLQASHR 10 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 20116200.0 5574300.0 9163400.0 5378500.0 False True 8456620.635917269 7528119.676029025 4315437.117519708 1.0 0.890204255356486 0.5103027915419341 23.011649830091923 -6.9482072560867785 0.5781910071682276 1.004572560212221 0.37720227530716005 0.9990529782798026 0.006456643084231696 0.0842137215024627 0.03900403363510284 0.006778187973314556 0.03171983851169691 1.1266596579576738e-07 6.9482072560867785 -0.6273702849050611 QVLQLQASHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVLQLQASHR 10 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 28922600.0 13749000.0 6647300.0 8526300.0 False True 18832376.852754336 6353600.306318444 6512563.54466056 1.0 0.3373764424955842 0.34581739711246606 24.16671175961132 -10.09030534451341 5.235114567918312 1.0000113798388124 0.3415969198031478 0.9998767439138446 0.0034460052952901142 4.577067584293381e-07 7.95322853843341e-08 0.003336637888237071 0.0011121934261918793 8.122592307365244e-11 10.09030534451341 -0.6584144600356645 QVLQLQASHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVLQLQASHR 10 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 13305700.0 5985800.0 4714000.0 2605900.0 False True 4977457.915901788 4688604.746344262 3150781.641679744 1.0 0.9419677324373333 0.6330102021784554 22.246977687424355 -6.938415554769022 0.674145257000358 1.003581393310593 0.5534399626931961 0.9979488745091997 0.007294942923931094 0.08849707570117635 0.057958085608985334 0.007018544731071463 0.026782333811202836 1.1523501036824609e-07 6.938415554769022 -0.450141430617397 QVLQLQASHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVLQLQASHR 10 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 18855100.0 5574300.0 7899100.0 5381700.0 False True 7216041.23588026 7459508.14113305 4402285.820905145 1.0 1.0337396776562475 0.6100693825051466 22.782776152184372 -6.8876331592688675 1.03632275314932 1.0240728296057355 0.5752810893178136 0.9793381130189306 0.027636152255914946 0.12108284318161548 0.2332539228046074 0.020380317742141177 0.05039237441472075 1.2952894872068675e-07 6.8876331592688675 -0.4487917402879219 QVLVAPGNAGTACSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVLVAPGNAGTACSEK 16 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 4672600.0 2261300.0 0.0 2411300.0 False True 2189516.269273041 0.0 1779708.192550585 1.0 0.0 0.812831682288198 21.062180739147774 -9.733319791375424 10.581701216695311 0.9999999998110115 0.40641584213508397 0.41556463568985047 0.3318371447290227 0.0 0.0 0.32129993619100233 0.10709997793237706 1.8479074170683196e-10 9.733319791375424 -0.5935841576759275 QVLVAPGNAGTACSEK(ub)ISNTAISISDHTALAQFCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVLVAPGNAGTACSEKISNTAISISDHTALAQFCK 35 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 108152000.0 15129000.0 13694000.0 79329000.0 True False 22951799.078053284 11250198.708289662 63649588.37886406 1.0 0.4901663120189651 2.7731851504279836 24.452103908014365 -6.848093837498652 1.2443139149139684 0.7283262598622103 2.861122217650397 0.9374813591982836 0.24464913669428537 0.15956233721048235 0.47638394326264705 0.15392695599751632 0.35577693542698474 1.418750940719466e-07 6.848093837498652 2.1327959577881868 up QVMEEK(ub)LNATNIELATVQPGQNFHMFTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVMEEKLNATNIELATVQPGQNFHMFTK 28 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 52584000.0 10886000.0 11539000.0 30159000.0 True False 10540429.888695134 16146582.875090057 22259453.149393756 1.0 1.5318713795921794 2.1118164424458206 23.329430372329085 -6.970016512908841 0.2577915409614457 0.8327264416923768 2.8281180931173378 0.9999825111408772 0.0018987661611253926 0.07629734812892068 0.009010976098144968 0.012281388082540588 0.054901958589878716 1.0714785643003665e-07 6.970016512908841 1.995391651424961 QVMEEK(ub)LNATNIELATVQPGQNFHMFTK ddPTM_RPMI8226_Bortezomib_8h_R1 2 QVMEEKLNATNIELATVQPGQNFHMFTK 28 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 328499800.0 31194700.0 204975000.0 92330100.0 True False 47324640.53804927 168395609.77301538 74081015.26527953 1.0 3.558307212869887 1.565379354666582 25.496088211958938 -6.583177278781284 2.253625318461162 2.7386693662496744 1.5704244155500613 0.0 1.110479775468655 0.6897455918977875 6.592989028071055 0.4128578673628663 1.2408774730843424 2.611095289093497e-07 6.583177278781284 -1.168244950699613 QVMEEK(ub)LNATNIELATVQPGQNFHMFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVMEEKLNATNIELATVQPGQNFHMFTK 28 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 34233000.0 10886000.0 10629000.0 12718000.0 True False 9052191.331569187 10571739.467308696 15377274.998612005 1.0 1.167865225124014 1.6987350836238204 23.10983564776336 -6.950259163144848 0.555990486477162 0.992905677625005 1.8988917868986037 0.9992214690474519 0.008309621064120896 0.08338183350849093 0.03553287912966964 0.008951203848836723 0.044092246438439016 1.1213490949201625e-07 6.950259163144848 0.9059861092735987 QVMEEK(ub)LNATNIELATVQPGQNFHMFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVMEEKLNATNIELATVQPGQNFHMFTK 28 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 169936300.0 24762100.0 138749000.0 6425200.0 True False 32055026.583963986 131027496.17982662 5255879.528119312 1.0 4.087580331172619 0.16396428542500865 24.934047269390785 -6.696889785345161 1.8420122695355192 2.923110102217257 0.176348293425476 0.4027613719244566 1.3040687274513278 0.40205709634945086 2.649949760756049 0.5652728984750679 1.4593123737961304 2.0096027421145654e-07 6.696889785345161 -2.7467618087917813 QVMMFSATLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVMMFSATLSK 11 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;A0A140T996;A0A140T9X9;F6UJC5;A0A140TA18;A0A140T9K1;A0A140T973;H0YCC6 Q13838-2 DDX39B Spliceosome RNA helicase DDX39B 0 100481000.0 0.0 51719000.0 48762000.0 False True 0.0 42489340.36760859 39124169.32685619 0.0 QVMMFSATLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVMMFSATLSK 11 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;A0A140T996;A0A140T9X9;F6UJC5;A0A140TA18;A0A140T9K1;A0A140T973;H0YCC6 Q13838-2 DDX39B Spliceosome RNA helicase DDX39B 0 121333000.0 0.0 79714000.0 41619000.0 False True 0.0 75277845.82576236 34044769.04700211 0.0 QVNITVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVNITVQK 8 0 H3BPZ1;H3BS72;Q9P035 H3BPZ1 HACD3 Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 0 3717530.0 1544500.0 954830.0 1218200.0 False True 2024854.456959275 812373.0858981898 1092152.3497995357 1.0 0.40120072981350513 0.5393732601599531 20.949386782620596 -10.054108379537434 7.51143884989176 1.0000000415942778 0.47028699498724713 0.9514478562078378 0.05640869930300372 3.930045451291069e-08 4.984098280625487e-09 0.05461749231473019 0.01820582941514628 8.828595525808236e-11 10.054108379537434 -0.5297130466070307 QVQEFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVQEFLK 7 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 5191840.0 2242300.0 722440.0 2227100.0 False True 2171119.413872967 1010914.0594748294 1643755.6984321356 1.0 0.4656188199577208 0.7571005481913637 21.050007647218514 -10.104872742585634 5.359485626975329 1.0000061962107385 0.6113596840743103 0.7032945675765612 0.11899691725366776 8.810370282327664e-06 1.4713928554006555e-06 0.11522010608808933 0.03840608989766971 7.854657588747983e-11 10.104872742585634 -0.3886465121364282 QVQHILASASPSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVQHILASASPSGR 14 0 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-5;H0Y9T9 D6REX3 SEC31A Protein transport protein Sec31A 0 2578300.0 707130.0 803170.0 1068000.0 False True 927054.277856662 683340.1667321393 957493.6049793989 1.0 0.7371091240871174 1.0328344605594315 19.8222942837323 -6.672212697224673 1.9297153442820205 0.8325142175092252 1.031645738990609 0.28877353068773026 0.11161441995989119 0.4560761331391721 3.2763697985518827 0.046531417696717106 0.12395425593150522 2.127097037708429e-07 6.672212697224673 0.1991315214813839 QVQHILASASPSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVQHILASASPSGR 14 0 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-5;H0Y9T9 D6REX3 SEC31A Protein transport protein Sec31A 0 2434130.0 707130.0 661300.0 1065700.0 False True 968575.0704697197 632081.5793733374 814003.6087804503 1.0 0.6525891473407461 0.8404135452151288 19.885504345255193 -10.235718771160837 5.338045594455118 1.0000201377086926 0.7465013463417294 0.7083500573599175 0.07667898934173874 1.9253177036930004e-05 2.7565028062162217e-06 0.07425028632055486 0.024748037393395993 5.811406152463359e-11 10.235718771160837 -0.2535187913669632 QVQQLLGK(ub)VQENSAYICSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVQQLLGKVQENSAYICSR 19 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 21119400.0 4040200.0 8383200.0 8696000.0 True False 5296741.325352451 7132459.2374576675 7796221.337922149 1.0 1.3465749598377954 1.4718901413225765 22.336673623410917 -12.355088744951432 0.163322076501006 4.208861219972928e-18 1.601508135809062 0.999528021189617 0.00433593959959117 6.305183516053854 0.11282177725821899 2.1983598700905587 0.10755961370337994 4.4148022482918663e-13 12.355088744951432 1.601508135809062 QVQQLLGK(ub)VQENSAYICSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVQQLLGKVQENSAYICSR 19 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 13202200.0 3937300.0 2960800.0 6304100.0 True False 3812312.5666690543 4143062.8803680222 4652867.091053851 1.0 1.0867584459340267 1.220484157498979 21.86223497815675 -6.964801822923743 0.3614469155148126 0.9886656525654548 1.3231698244048502 0.9999089860710884 0.0008651789233802404 0.07802838359057486 0.015098126105700313 0.0017889692809488354 0.011412041346583175 1.0844216439659501e-07 6.964801822923743 0.3345041718393954 QVQQLLGK(ub)VQENSAYICSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVQQLLGKVQENSAYICSR 19 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 58921000.0 11257000.0 12897000.0 34767000.0 True False 17077691.996936068 10595429.585279077 27895287.21108256 1.0 0.6204251480340562 1.6334342612624289 24.02560967608051 -6.80519362469272 1.4344236988006092 0.7919298957748138 1.649311557955886 0.8469688102289017 0.16346560947383715 0.2134225505742779 0.8663015068777252 0.0896259871700307 0.20783149456615058 1.5660527096817083e-07 6.80519362469272 0.8573816621810721 QVQQLLGK(ub)VQENSAYICSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVQQLLGKVQENSAYICSR 19 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 21914400.0 4040200.0 5747200.0 12127000.0 True False 5533971.1222996535 5493269.700551107 9262852.36340484 1.0 0.9926451691111042 1.6738165340399611 22.39988368493381 -6.904461864128755 0.9326502523690063 0.9750405396177918 1.7521595505388243 0.9886576632441756 0.034014932941014445 0.10819488318688691 0.1594855113862453 0.027107289273291004 0.07224434647769228 1.2460576501456096e-07 6.904461864128755 0.7771190109210325 QVQQLLGK(ub)VQENSAYICSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVQQLLGKVQENSAYICSR 19 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 23574700.0 3937300.0 3061400.0 16576000.0 True False 3274039.401964665 3044907.630559678 20041964.961235438 1.0 0.9300155730357152 6.121479463322519 21.642640253591026 -6.903844182894756 0.9366310076890638 0.80632819998789 6.711060254508451 0.9883840647232991 0.262001313595722 0.1086311622751382 0.16188525627135453 0.20817868774408024 0.5528861899426657 1.2478311334683762e-07 6.903844182894756 5.904732054520561 up QVQQLLGK(ub)VQENSAYICSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVQQLLGKVQENSAYICSR 19 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 61884000.0 11257000.0 13782000.0 36845000.0 True False 14572408.408643978 13015019.58464832 30139588.061625473 1.0 0.8931275613252883 2.068264024479814 23.79673599817296 -6.884679305727939 1.05332304086439 0.9285726909610874 2.1594064173958145 0.9772693640744664 0.07999258734044942 0.12356738091754045 0.24790510984192685 0.058230497101309994 0.14265312961643858 1.3041294258668288e-07 6.884679305727939 1.230833726434727 up QVQSLTCEVDALK(ub)GTNESLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVQSLTCEVDALKGTNESLER 21 1 B0YJC4;P08670;B0YJC5 B0YJC4 VIM Vimentin 1 107762000.0 12029000.0 28240000.0 67493000.0 True False 18248872.437695988 23200351.359872945 54152978.96676725 1.0 1.2713306775025113 2.967469861584738 24.121303989639838 -6.934974022909908 0.704776479421191 0.9783407276268947 3.3643086668578146 0.997428577227686 0.04414725561575161 0.09013621154133131 0.06562424078660023 0.04148494492207271 0.14949759345800703 1.1615180873402067e-07 6.934974022909908 2.3859679392309197 up QVQSLTCEVDALK(ub)GTNESLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVQSLTCEVDALKGTNESLER 21 1 B0YJC4;P08670;B0YJC5 B0YJC4 VIM Vimentin 1 100450000.0 12029000.0 23719000.0 64702000.0 True False 15571777.627039015 22399016.79932328 52926899.898583114 1.0 1.4384367241688172 3.398899031712361 23.892430311732287 -6.94232447688711 0.6375709143475614 0.9785699121376025 3.9658039316181948 0.9984527982127335 0.04102527089571881 0.08672199652472194 0.04989919983898916 0.04067707760116249 0.16708156852794362 1.142024768554501e-07 6.94232447688711 2.987234019480592 up QVRPVTEK(ub)LPANHPLLTGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVRPVTEKLPANHPLLTGQR 20 2 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 36472200.0 6315200.0 15696800.0 14460200.0 True False 8279288.35648379 13354898.625647167 12963997.216032887 1.0 1.6130490992246327 1.5658347261066639 22.9810753359987 -10.064959713555778 4.479129670255534 0.9999633868442663 1.5894419127052903 0.9952110211935893 0.019275187268588245 2855373.6858925093 2142372.1337850187 949.2086099296565 0.006598409876718975 8.610736242232142e-11 10.064959713555778 0.589478525861024 QVRPVTEK(ub)LPANHPLLTGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVRPVTEKLPANHPLLTGQR 20 2 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 45512400.0 6739600.0 3036000.0 35736800.0 True False 6525655.087070523 4248290.632530841 26376259.99898053 1.0 0.6510136646584506 4.041932901302217 22.63769130524873 -6.881518648714693 1.071341592385234 0.7790651234149595 4.289307786322223 0.9748878793484204 0.24133364655500278 0.12629116576916063 0.2642554470665528 0.17328740221766675 0.42070051837781747 1.313655085067951e-07 6.881518648714693 3.510242662907264 up QVRPVTEK(ub)LPANHPLLTGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVRPVTEKLPANHPLLTGQR 20 2 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 29753300.0 6315200.0 5511000.0 17927100.0 True False 8650100.101862973 5267505.797560058 13693088.20021397 1.0 0.6089531607184054 1.5829976577109077 23.04428539752159 -6.7977553498753025 1.4651789960437078 0.7836241706667766 1.5956921412306022 0.8254844745232209 0.16719109134886162 0.2239785253829976 0.9495037187984159 0.08978204155994897 0.20908089182937908 1.5931059150609857e-07 6.7977553498753025 0.8120679705638256 QVRPVTEK(ub)LPANHPLLTGQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVRPVTEKLPANHPLLTGQR 20 2 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 23938500.0 6739600.0 2401400.0 14797500.0 True False 5604276.014903884 2388463.18155942 17891588.834090337 1.0 0.4261858579426844 3.1924888757280785 22.418096580683006 -6.852589232562932 1.2224144220061066 0.6929483816480736 3.308792261662244 0.9439977522761475 0.2820945638622913 0.15463816916567402 0.4433482095806342 0.18043917018552225 0.4183274972330826 1.404141151276329e-07 6.852589232562932 2.6158438800141703 up QVSCHENSK(ub)SCIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVSCHENSKSCIR 13 1 A0A0A0MTP7;Q99590;A0A087WUE7 A0A0A0MTP7 SCAF11 Protein SCAF11 1 14505830.0 910430.0 1458400.0 12137000.0 True False 1193582.5466166623 1240812.4047986737 10881179.66632489 1.0 1.0395698297666043 9.116403132040393 20.186866914106968 -6.9079724681078085 0.9094028212255943 0.7336066299875356 10.116263040947592 0.9901343518239307 0.37910901001990643 0.1057749225343084 0.1461420598818469 0.3073029762810657 0.8368683142613859 1.2360257882280185e-07 6.9079724681078085 9.382656410960056 up QVSCHENSK(ub)SCIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVSCHENSKSCIR 13 1 A0A0A0MTP7;Q99590;A0A087WUE7 A0A0A0MTP7 SCAF11 Protein SCAF11 1 1769110.0 607950.0 548040.0 613120.0 True False 588650.9600250049 766875.2299908444 452525.4787942664 1.0 1.3027673138565319 0.7687500905036219 19.167052917484625 -6.752888220241236 1.63900770190294 1.1774104482279548 0.7674414028723014 0.6613482324906881 0.127247910620067 0.2950424550832357 1.560230006864455 0.06130590594033687 0.14839432952042309 1.766492426251169e-07 6.752888220241236 -0.40996904535565337 QVSCHENSK(ub)SCIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVSCHENSKSCIR 13 1 A0A0A0MTP7;Q99590;A0A087WUE7 A0A0A0MTP7 SCAF11 Protein SCAF11 1 17820730.0 910430.0 1445300.0 15465000.0 True False 1247040.5744456416 1381441.867032034 11812485.511672756 1.0 1.107776198578093 9.472414734319186 20.25007697562986 -6.909708048486733 0.8976966400065658 0.7386151289915868 10.546767604986394 0.9908114720360011 0.38043415004579506 0.10461208036267654 0.13980781176242202 0.31101738227087855 0.8568483373382086 1.2310960886788433e-07 6.909708048486733 9.808152475994808 up QVSDLISVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVSDLISVLR 10 0 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 26719900.0 4628900.0 11504000.0 10587000.0 False True 6068532.726331362 9787648.042240776 9491558.79767501 1.0 1.6128524774649684 1.564061565737487 22.53291630749668 -10.112537086300014 4.700741954781214 0.9999618442838986 1.5884570215502025 0.9948704860211808 0.019918806349198997 8.272550343542644e-06 1.561827125411636e-06 0.019287596421910205 0.006428767098848489 7.717256117552245e-11 10.112537086300014 0.588495177266304 QVSDLISVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVSDLISVLR 10 0 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 23593000.0 7367400.0 6747500.0 9478100.0 False True 7133525.919710876 9441811.93774765 6995501.2730948925 1.0 1.3235827617389984 0.9806512728530776 22.766183909602027 -6.659341930865729 1.9759369763054335 1.2084066206513742 0.9821030336909183 0.23257022744519018 0.1377973298349615 0.4859702444331416 3.646988316021841 0.05636570116410198 0.15267616133284154 2.191079164852933e-07 6.659341930865729 -0.22630358696045583 QVSDLISVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVSDLISVLR 10 0 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 26074900.0 4628900.0 8342000.0 13104000.0 False True 6340329.421318962 7973422.856694966 10009105.085351449 1.0 1.2575723321070398 1.5786411746519757 22.596126369019572 -6.968150634030988 0.29908009028322374 0.9437036538327798 1.9025571299116806 0.999964149279922 0.0014172579305294865 0.07690747608731353 0.011166664386739711 0.005351086078631567 0.028823415396542616 1.0760919089177533e-07 6.968150634030988 0.9588534760789008 QVSDLISVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVSDLISVLR 10 0 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 13405500.0 7367400.0 3469000.0 2569100.0 False True 6126319.531159553 3450311.808457415 3106286.9318237198 1.0 0.5631948824916028 0.5070396534207188 22.546589185036304 -13.999999999999998 0.28920700803169264 4.747171910260249 0.49161453461593196 0.9996256875282418 0.004263019734104958 15.918842564803874 0.1705243732972439 35.47317874750397 0.021284770797763173 1.0000000000000041e-14 13.999999999999998 -4.255557375644317 QVSDLISVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVSDLISVLR 10 0 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 10988800.0 4027800.0 3933900.0 3027100.0 False True 5214066.499807772 3714975.0068239784 2476198.860668926 1.0 0.7124909141379265 0.4749074183768497 22.31397755233786 -7.123569881773383 0.17136218887684265 1.2165902719408905 2.291926697192423e-14 0.9999962758187246 0.0004142732152077166 0.07953228680619277 0.006407148717766801 0.012549452428502597 0.030973886351765637 7.523676579089791e-08 7.123569881773383 -1.2165902719408677 down QVSISFCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVSISFCK 8 0 C9JA08;Q96D46;C9IY70;C9IZW9;C9K0C2;C9J0B9 C9JA08 NMD3 60S ribosomal export protein NMD3 0 14862600.0 6193000.0 3873700.0 4795900.0 False True 8119082.973097307 3295759.0595643334 4299666.273521259 1.0 0.4059275007392924 0.5295753581738557 22.952885357710485 -10.349111591482815 8.852405750026533 1.0000009208443192 0.4677514294571279 0.9610978970141375 0.050479026417179926 9.173664390981209e-07 6.746379400954656e-08 0.048876191628437426 0.016292035720541845 4.4759827952048967e-11 10.349111591482815 -0.5322494913871914 QVSISFCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVSISFCK 8 0 C9JA08;Q96D46;C9IY70;C9IZW9;C9K0C2;C9J0B9 C9JA08 NMD3 60S ribosomal export protein NMD3 0 12686900.0 2557700.0 4848700.0 5280500.0 False True 3880217.892916702 3983411.6019339846 4236806.860474635 1.0 1.0265948232457929 1.0918992122089026 21.887706238283997 -6.95584547654858 0.4904969551312671 0.9985772779760113 1.122688272103951 0.9995837015873321 0.000787778019920046 0.08122004935713946 0.02687995758734368 0.0009412532378031796 0.005386110405506857 1.1070175945332431e-07 6.95584547654858 0.1241109941279398 QVSISFCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVSISFCK 8 0 C9JA08;Q96D46;C9IY70;C9IZW9;C9K0C2;C9J0B9 C9JA08 NMD3 60S ribosomal export protein NMD3 0 15573400.0 6193000.0 2852600.0 6527800.0 False True 8482719.459532144 2726562.699713265 4986068.084261077 1.0 0.3214255419763282 0.5877912275712674 23.016095419233377 -10.349258234865916 5.82547319622062 1.0000882733780352 0.45460838477399035 0.8482511641785719 0.10874333578237337 0.00012469107637592494 1.3928607717338959e-05 0.10530717595343558 0.03509676070801378 4.4744716950540074e-11 10.349258234865916 -0.5454798886040448 QVSISFCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVSISFCK 8 0 C9JA08;Q96D46;C9IY70;C9IZW9;C9K0C2;C9J0B9 C9JA08 NMD3 60S ribosomal export protein NMD3 0 10043500.0 2557700.0 3472200.0 4013600.0 False True 3310993.069804446 3278969.0176908923 3283165.9830137095 1.0 0.9903279615999181 0.9915955466519959 21.658832560376446 -10.65085212982934 6.5655875117238685 1.0000461022852498 0.9909617541280309 0.9854607974955295 0.0005174894305283117 3.5100249137199304e-07 1.8665509130303273e-08 0.0005036132577698195 0.00016701899552287166 2.2343328471376933e-11 10.65085212982934 -0.009084348157218924 QVSSHIQVLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVSSHIQVLAR 11 0 A0A0A0MRF3;H0YEJ9;P28347-2;Q15561-3;Q15561;P28347;Q99594;A0A1X7SBS4;Q53GI4;H0YE88;H0YGS2;Q15562-2;H0YG62;Q15562;Q15562-4 A0A0A0MRF3 TEAD4;TEAD1;TEAD3;TEAD2 Transcriptional enhancer factor TEF-1;Transcriptional enhancer factor TEF-3;Transcriptional enhancer factor TEF-5;Transcriptional enhancer factor TEF-4 0 3846190.0 1505400.0 749090.0 1591700.0 False True 2061987.0619053256 715992.7268906308 1215773.2420904979 1.0 0.3472343450249568 0.5896124493463573 20.975603849758816 -10.244255292952053 5.537328112462225 1.000034734371515 0.468423397185698 0.8651078781784131 0.09895044673516473 4.2433478141823964e-05 5.791223612967581e-06 0.09581459941861517 0.03193611935874465 5.6982920897129234e-11 10.244255292952053 -0.5316113371858171 QVSVALSSSSIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVSVALSSSSIR 12 0 Q8IVD9 Q8IVD9 NUDCD3 NudC domain-containing protein 3 0 23512900.0 8110600.0 8450900.0 6951400.0 False True 10633075.14316212 7190058.661350201 6232135.810537261 1.0 0.6761974842220464 0.5861085082752379 23.342055556677835 -13.99999999962118 0.17948638691009805 2.677431998662774 0.5141654141496063 0.9994987656440336 0.003978912759204691 12.198119920816747 0.13429779993083177 7.134946561144844 0.0675583787103125 1.0000000008722665e-14 13.99999999962118 -2.163266584513168 QVSVALSSSSIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVSVALSSSSIR 12 0 Q8IVD9 Q8IVD9 NUDCD3 NudC domain-containing protein 3 0 17597000.0 5802000.0 1806600.0 9988400.0 False True 5617818.685854232 2527984.801294544 7372138.39442304 1.0 0.4499940177243624 1.3122777374403727 22.42157863180199 -6.734426036222785 1.70730221007386 0.6706411218960342 1.312171142456079 0.5795280368267333 0.2311405853911366 0.32802262945609995 1.8751315365347814 0.10720520061121151 0.2646785419960872 1.8432063748312513e-07 6.734426036222785 0.6415300205600447 QVSVALSSSSIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVSVALSSSSIR 12 0 Q8IVD9 Q8IVD9 NUDCD3 NudC domain-containing protein 3 0 29820500.0 6307100.0 14481000.0 9032400.0 False True 9568331.810773324 11896752.409430582 7247142.180958444 1.0 1.2433465566103807 0.7574091622531975 23.189835989530852 -6.770561965021946 1.5724562156394204 1.1394765335035077 0.754627016177428 0.7326641198176971 0.10257310339751503 0.26551448547747336 1.2957602167189692 0.051416152533256314 0.12232111588663934 1.6960475933730516e-07 6.770561965021946 -0.38484951732607975 QVSVALSSSSIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVSVALSSSSIR 12 0 Q8IVD9 Q8IVD9 NUDCD3 NudC domain-containing protein 3 0 20894900.0 8110600.0 4107200.0 8677100.0 False True 11109308.00072362 3925730.323305872 6627747.690484052 1.0 0.35337307445703764 0.5965941073964592 23.405265618200726 -10.253916518903536 5.56628574685026 1.0000369197737082 0.4749835909267846 0.8613561729334989 0.09929457090243476 4.549700947246338e-05 6.098318884964141e-06 0.09614829374241676 0.032047184956152934 5.572928627683719e-11 10.253916518903536 -0.5250533288469237 QVSVALSSSSIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVSVALSSSSIR 12 0 Q8IVD9 Q8IVD9 NUDCD3 NudC domain-containing protein 3 0 11266600.0 5802000.0 2415300.0 3049300.0 False True 4824620.072181189 2402288.299500484 3686894.531629783 1.0 0.4979227925846646 0.7641833919500638 22.201983907236265 -10.038812883123363 5.141738543607746 1.0000042149364237 0.6310530922659441 0.7191070345919228 0.10870043451376056 5.252141984018669e-06 9.818789119810553e-07 0.10524994422497219 0.03508291438239707 9.145071743311593e-11 10.038812883123363 -0.3689511226704796 QVSVALSSSSIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVSVALSSSSIR 12 0 Q8IVD9 Q8IVD9 NUDCD3 NudC domain-containing protein 3 0 25751600.0 6307100.0 10985000.0 8459500.0 False True 8164665.281527785 10373675.093408938 6919957.801799992 1.0 1.2705573021932628 0.8475494785384661 22.9609623116233 -6.7339726038498116 1.7090557552942889 1.1620978888203626 0.8476273903015338 0.5774602705498062 0.11370437295783149 0.3288338635486939 1.883456823070174 0.052688548925555606 0.13014369071765033 1.8451318100523588e-07 6.7339726038498116 -0.3144704985188288 QVTAAQLHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVTAAQLHLR 10 0 Q9BYD1;E5RJI7 Q9BYD1 MRPL13 39S ribosomal protein L13, mitochondrial 0 3947270.0 1928300.0 873970.0 1145000.0 False True 2641244.62034811 835355.1155676938 874574.5820152158 1.0 0.31627328613644123 0.3311221441882005 21.332786493025324 -10.002210865470584 6.060821226426166 1.0000006063442375 0.3236977152418926 0.9996385825900123 0.006062020915173602 4.966795603296314e-08 8.182302703968787e-09 0.005869531759453838 0.0019565088373727146 9.94922229808077e-11 10.002210865470584 -0.6763028911023449 QVTDAETK(ub)PK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVTDAETKPK 10 1 O43684-2;O43684 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 39769100.0 15896100.0 21865700.0 2007300.0 True False 20839941.038051393 18603422.791831024 1799603.851381224 1.0 0.8926811624784956 0.08635359611120538 24.31284786005103 -7.0340576923323495 0.8247229719261207 1.004696884981857 3.52536262045315e-26 0.9957843285998632 0.026475275748358635 0.07881423557548888 0.09082157991467621 0.023866873677366732 0.05947624527187149 9.245753438002871e-08 7.0340576923323495 -1.004696884981857 down QVTDAETK(ub)PK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVTDAETKPK 10 1 O43684-2;O43684 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 41394600.0 20493200.0 19669700.0 1231700.0 True False 19842654.58341055 27523913.786130395 909080.8197920453 1.0 1.38710844712994 0.0458144758792547 24.242101708995555 -6.829534645630034 1.3300804203454444 1.2069205414384678 0.01009843228765399 0.904896899911639 0.1738252919512728 0.1814095501889609 0.6278429886138767 0.10261592140480956 0.23614133554144032 1.4806941289053877e-07 6.829534645630034 -1.1968221091508138 down QVTDAETK(ub)PK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVTDAETKPK 10 1 O43684-2;O43684 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 16427560.0 13736400.0 1983860.0 707300.0 True False 20839123.065355968 1629824.683031071 567501.844979397 1.0 0.07820984971006652 0.027232520447217922 24.312791232812543 -13.302003088211936 0.41937243771514776 9.998312291156186 0.025466485353526483 0.9998506264712234 0.005463604803235387 16.2767472118256 0.2151235283659367 131.3080463518067 0.012392360664049246 4.9888093996950616e-14 13.302003088211936 -9.97284580580266 QVTDAETK(ub)PK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVTDAETKPK 10 1 O43684-2;O43684 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 33386860.0 15896100.0 17053300.0 437460.0 True False 21773317.74595012 16299828.818278145 334140.9577715081 1.0 0.7486148417280111 0.015346350136908231 24.37605792157392 -7.323975329448477 0.7705913668906593 0.9907502927477593 1.598938137839461e-19 0.9898485932542065 0.0420871737792925 0.10513120080099576 0.12465828484573191 0.036398904922533865 0.06915652581179345 4.742689258365942e-08 7.323975329448477 -0.9907502927477593 down QVTDAETK(ub)PK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVTDAETKPK 10 1 O43684-2;O43684 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 17833620.0 13736400.0 2624510.0 1472710.0 True False 17782040.584924642 2478453.711370296 1204691.8912806741 1.0 0.1393796004195094 0.06774767415062558 24.083917554904993 -13.76660326961635 0.35437051772644956 9.999999999717323 0.05832000663438752 0.9997561590980379 0.006614602253616102 17.821957601349443 0.1914933612817568 120.12483092329565 0.02106892275502609 1.7115781371444043e-14 13.76660326961635 -9.941679993082936 QVTDAETKPK(ub)ST ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVTDAETKPKST 12 2 O43684-2 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 5982740.0 3014600.0 458440.0 2509700.0 True False 4573368.596780973 376627.8001919311 2013656.694959411 1.0 0.08235238254293031 0.4403005470358874 22.124825769098386 -10.594560841271024 6.415957638916016 1.0018500014598524 0.2613264664650179 0.8502569558134805 0.14613172622892737 0.003873832020076074 0.00024479620214669313 0.14173954991461246 0.04716381183643147 2.543543437563692e-11 10.594560841271024 -0.7405235349948345 QVTITGSAASISLAQYLINAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVTITGSAASISLAQYLINAR 21 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 6930240.0 3503400.0 2431800.0 995040.0 False True 4592991.326973861 2068984.919082156 892082.8058976606 1.0 0.45046567079962846 0.19422697374989784 22.131002628619235 -9.522143977208778 0.22334076754287485 1.4669396712541327 8.5118006932899e-18 0.9993049027376618 0.008862251525125044 0.9376747379943754 0.08947789724878219 0.42548704528586995 0.12679098586661933 3.005079894063463e-10 9.522143977208778 -1.4669396712541327 QVTITGSAASISLAQYLINAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVTITGSAASISLAQYLINAR 21 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 41176400.0 24618000.0 6182400.0 10376000.0 False True 23836515.06521188 8651064.560790094 7658214.326672294 1.0 0.3629332785066329 0.3212807873013723 24.50666999121768 -13.884469292166965 0.38848181302638857 9.999785448457645 0.31811880826979116 0.9998186086267885 0.004183200866012995 22.88752361052089 0.20388892577322348 172.24036780504076 0.01101525001794605 1.3047602215794172e-14 13.884469292166965 -9.681666640187855 QVTITGSAASISLAQYLINAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVTITGSAASISLAQYLINAR 21 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 403915000.0 96125000.0 163570000.0 144220000.0 False True 145828652.67881995 134379655.52175677 115714853.78612839 1.0 0.9214900710748593 0.7934987511746704 27.119698969959796 -6.963836464233367 0.37748957482716616 1.009043731272272 0.701436968967279 0.9998871098014933 0.0009042385444727936 0.07835804829495743 0.016265954655645582 0.0016702449451176066 0.01082836068356849 1.0868347996715926e-07 6.963836464233367 -0.30760676230499295 QVTITGSAASISLAQYLINAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVTITGSAASISLAQYLINAR 21 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 5920960.0 3503400.0 954860.0 1462700.0 False True 4798701.655825114 912671.1279002343 1117240.3852521023 1.0 0.19019126283717774 0.2328213890721652 22.194212690142127 -10.03485192773621 5.497169119377457 1.000003901359705 0.2115063259540928 0.9978125050241661 0.01740367615979029 22226219.1904995 40573025.35529711 745.7260085434596 0.0059577420975175845 9.22886030577366e-11 10.03485192773621 -0.7884975754056123 QVTITGSAASISLAQYLINAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVTITGSAASISLAQYLINAR 21 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 44691100.0 24618000.0 7653100.0 12420000.0 False True 20470957.762315817 7611871.231278589 15016964.576408302 1.0 0.3718375720207378 0.7335741078051777 24.287075266651957 -10.711192002141727 6.981674500791468 1.0043075447086431 0.5527058399130651 0.6709053544054224 0.1476783223323176 0.00994927483503442 0.0004115669452195648 0.14367652136301864 0.04766297358240975 1.9445002255469435e-11 10.711192002141727 -0.45160170479557804 QVTITGSAASISLAQYLINAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVTITGSAASISLAQYLINAR 21 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 293280000.0 96125000.0 120520000.0 76635000.0 False True 124435707.40702668 113812956.05440553 62688216.34150276 1.0 0.9146326116998367 0.503779965154623 26.890825292052245 -6.940660152218456 0.6533927118382702 1.0045643914888105 0.3908006072655928 0.9982491007219836 0.009064231626082463 0.08746673784892232 0.05324774033003297 0.008868125430622908 0.03525967099932968 1.1464096887150041e-07 6.940660152218456 -0.6137637842232178 QVTITGSAASISLAQYLINVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVTITGSAASISLAQYLINVR 21 0 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6;H3BSS4 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 280371700.0 74052200.0 105499500.0 100820000.0 False True 112342601.3409886 86672289.95364432 80892882.80902418 1.0 0.7714997598335087 0.7200552759455296 26.743329873735618 -13.999999999999998 0.20950842508691522 2.31883542338057 0.689609716653901 0.9994897396787985 0.0027483456285485653 12.735215745389135 0.14508163848564185 6.9120820282820965 0.030578435939785133 1.0000000000000041e-14 13.999999999999998 -1.629225706726669 QVTITGSAASISLAQYLINVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVTITGSAASISLAQYLINVR 21 0 Q15366-3;Q15366-2;F8VZX2;Q15366-4;Q15366-5;Q15366-7;Q15366-8;Q15366-6;Q15366;H3BRU6;H3BSS4 Q15366-3;Q15366-4;Q15366-6 PCBP2 Poly(rC)-binding protein 2 0 184533200.0 74052200.0 63256000.0 47225000.0 False True 95862032.68709116 59735747.99350702 38630534.56941957 1.0 0.6231429307210077 0.40298054909304654 26.514456195828068 -9.340204400456605 0.1386617018640879 1.5881955749619523 1.128663362045035e-18 0.99985249302775 0.002993974382435017 0.7808619882317405 0.051479067789098866 0.37359776570227843 0.19236576742422604 4.568731119294672e-10 9.340204400456605 -1.5881955749619523 QVTQLAIDTEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVTQLAIDTEER 12 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 15163800.0 3326300.0 6016100.0 5821400.0 False True 4360811.511935023 5118521.330574125 5219057.370811869 1.0 1.1737543153528514 1.196808749134864 22.056165203248995 -13.366356796393815 0.2926658490824567 3.592087110836499e-06 1.203047828030321 0.9995995301629568 0.001757986035476146 11.201800744427073 0.1696855324051315 6.668040974235473 0.008607957123751321 4.301730548603607e-14 13.366356796393815 1.20304423594321 QVTQLAIDTEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVTQLAIDTEER 12 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 7754000.0 2081300.0 0.0 5672700.0 False True 2015230.270746022 0.0 4186849.6926478297 1.0 0.0 2.077603613555235 20.94251326737398 -6.775820273862216 1.5520910462905007 0.4306964877335502 2.0919712847226943 0.7523326188202726 0.4222040915309246 0.25712991297889437 1.2231354230417026 0.2143149170939145 0.5075021236842157 1.6756361689965308e-07 6.775820273862216 1.6612747969891442 QVTQLAIDTEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVTQLAIDTEER 12 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 14034900.0 3326300.0 5472900.0 5235700.0 False True 4556122.99987757 5231089.181539905 3999135.4926262614 1.0 1.1481448551060787 0.8777496772439471 22.119375264771886 -6.75793670800891 1.6201175497342213 1.086271236884824 0.8768574629832195 0.682524085023019 0.062293325555579385 0.28640320202647296 1.4811152326971608 0.030343477384047836 0.07307295942093954 1.7460765991931641e-07 6.75793670800891 -0.20941377390160443 QVTQLAIDTEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVTQLAIDTEER 12 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 4902090.0 2081300.0 1829200.0 991590.0 False True 1730693.1672234945 1819345.7365322295 1198926.8844058542 1.0 1.051223735661335 0.6927437555723762 20.722918542808255 -6.870665177037608 1.130501364390343 1.0290934099384563 0.6714759523633639 0.9653461000783478 0.029468960651132317 0.13622226558121145 0.3249696001311441 0.020221042261812268 0.04793272125296087 1.3468983564268755e-07 6.870665177037608 -0.35761745757509245 QVVESAYEVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVVESAYEVIK 11 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 55678700.0 6466700.0 21287000.0 27925000.0 False True 8477906.323611883 18111062.576076105 25035588.875514705 1.0 2.136265946420621 2.953039101857954 23.015276594786865 -7.833396903234298 0.1674247963881325 1.8069059350734827e-09 4.398717117069365 0.9999411615273329 0.006143194205204825 0.12813796608758657 0.02467502969627482 0.2375008123812449 0.3363741060972034 1.4675844340717354e-08 7.833396903234298 4.39871711526246 QVVESAYEVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVVESAYEVIK 11 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 49088600.0 16806000.0 4975600.0 27307000.0 False True 16272502.72913929 6962383.027411216 20154477.50755977 1.0 0.42786184419828827 1.238560401128033 23.955932820399653 -6.717105457932027 1.7699981506235194 0.6508436232547155 1.2370741521881752 0.49873023940971717 0.24084690367287107 0.3609575317627734 2.208481879521311 0.10811647877935886 0.2723137623938257 1.9182028948410135e-07 6.717105457932027 0.5862305289334597 QVVESAYEVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVVESAYEVIK 11 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 138219400.0 3868800.0 130520000.0 3830600.0 False True 5869252.447165872 107227686.24258558 3073480.230988377 1.0 18.269394136277675 0.5236578693207327 22.484745331697646 -6.5267447220381065 2.4893430451291674 9.999999999999998 0.5236017957416429 0.26824969199964044 7.0618986220543505 0.5591640615562117 6.4762393918588 2.7347252394338826 8.896367105328395 2.9734132882098837e-07 6.5267447220381065 -9.476398204258356 QVVESAYEVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVVESAYEVIK 11 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 53689700.0 6466700.0 24770000.0 22453000.0 False True 8857613.745996537 23675579.496563733 17150063.83405033 1.0 2.6729071932341393 1.9361945921159427 23.078486656309757 -10.081804550990958 4.998492407032659 0.999966437467688 2.304550892681074 0.8069814820553094 0.3007616599906073 104489472.42186806 1.5265312509930373 40364.201467903345 0.10295871600279749 8.283148529826999e-11 10.081804550990958 1.3045844552133858 QVVESAYEVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVVESAYEVIK 11 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 25248000.0 16806000.0 3815900.0 4626100.0 False True 13974933.632036714 3795342.9893031563 5593396.121330322 1.0 0.2715821834461207 0.40024491483149444 23.73633809583393 -10.37996731937926 7.693524550056961 1.000011271662313 0.33591354916427385 0.97261832502766 0.052526340134490056 1.0155448281655574e-05 8.184059189479647e-07 0.05085927129971342 0.016952803381508855 4.1690075403428565e-11 10.37996731937926 -0.6640977224980392 QVVESAYEVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVVESAYEVIK 11 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 17202700.0 3868800.0 7947200.0 5386700.0 False True 5008237.8654492125 7504931.333849754 4406375.872209479 1.0 1.4985173499095776 0.8798255974637599 22.255871653790095 -6.692254258952654 1.8580825251907707 1.3118835164355795 0.881889759383316 0.380994041597412 0.21074404612207173 0.4119247698732209 2.75895435059524 0.09066859780299015 0.2354667293166989 2.0311675099152586e-07 6.692254258952654 -0.4299937570522635 QVVK(ub)QGLQER ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVVKQGLQER 10 1 Q9UKN8 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 3359400.0 1145600.0 1151800.0 1062000.0 True False 1109233.5550697364 1611719.7465576516 783830.3406829184 1.0 1.453003057103086 0.7066413895436473 20.081131733980886 -6.74241923921457 1.6779973098448164 1.2687780180498158 0.7059818601754348 0.6156997858820482 0.19032491636859855 0.3134499051974825 1.7338634888011188 0.08969956994559726 0.21951939335560433 1.809592388199399e-07 6.74241923921457 -0.562796157874381 QVVMAVLEALTGVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVVMAVLEALTGVLR 15 0 Q8TEX9;Q8TEX9-2;H0YN14;H0YN07;H0YMR4 Q8TEX9 IPO4 Importin-4 0 713120000.0 192310000.0 330200000.0 190610000.0 False True 291748329.7442277 271273230.1356247 152935849.95266926 1.0 0.9298193082148807 0.5242047146825015 28.120149155642945 -6.936633183865288 0.6901833022608539 1.0049252314706518 0.4248722160848206 0.9976886694907697 0.010082398965197671 0.08933705197732304 0.06186133834844588 0.00958000781003641 0.03545921084792749 1.1570891364118316e-07 6.936633183865288 -0.5800530153858312 QVVMAVLEALTGVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVVMAVLEALTGVLR 15 0 Q8TEX9;Q8TEX9-2;H0YN14;H0YN07;H0YMR4 Q8TEX9 IPO4 Importin-4 0 275629000.0 192310000.0 0.0 83319000.0 False True 248949085.9968304 0.0 68155796.92513433 1.0 0.0 0.2737740395881674 27.891275477735395 -10.290294670569173 6.645119037586995 1.000016595534797 0.13688701979418577 0.9298356224061839 0.1117677836352555 2.7480332560711636e-05 2.9347449251892757e-06 0.10822076596170578 0.036072897055154846 5.125135234858776e-11 10.290294670569173 -0.8631295757406112 QVVNIPSFIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVVNIPSFIVR 11 0 P46781 P46781 RPS9 40S ribosomal protein S9 0 66193000.0 18382000.0 23725000.0 24086000.0 False True 24098980.011541203 20185322.479325693 21593811.769226436 1.0 0.8376006980236829 0.8960467106443916 24.52246874994345 -10.514174907951732 8.405791188928863 1.0000109820306227 0.8668237049797068 0.8737822534014158 0.023860484736833693 4.911097643457657e-06 2.8384413110215263e-07 0.023104719057963748 0.007700938334849431 3.0607305054747647e-11 10.514174907951732 -0.13318727705091582 QVVNIPSFIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QVVNIPSFIVR 11 0 P46781 P46781 RPS9 40S ribosomal protein S9 0 56799000.0 21608000.0 11252000.0 23939000.0 False True 20922065.867621202 15744982.278404852 17668657.745393965 1.0 0.7525539006533596 0.8444987152410135 24.318521976112958 -10.330314190486265 4.868193718243285 1.0001106760186715 0.7985263079986353 0.8649027942573504 0.03753631337279891 4.511459783652839e-05 6.206115121066628e-06 0.036364287915212436 0.012114793047519695 4.67396880517052e-11 10.330314190486265 -0.2015843680200362 QVVNIPSFIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QVVNIPSFIVR 11 0 P46781 P46781 RPS9 40S ribosomal protein S9 0 29566500.0 5923500.0 19747000.0 3896000.0 False True 8986382.565856855 16222993.565984806 3125953.8923225407 1.0 1.805286325959787 0.34785453094322827 23.099309050517387 -6.756705823665227 1.6248085254853757 1.4696647705512054 0.3433685447561257 0.6774005564541962 0.33856504978627494 0.2884871676892695 1.5002522678420744 0.1644671361815228 0.3965464609338245 1.7510323768794133e-07 6.756705823665227 -1.1262962257950797 QVVNIPSFIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVVNIPSFIVR 11 0 P46781 P46781 RPS9 40S ribosomal protein S9 0 64587000.0 18382000.0 22711000.0 23494000.0 False True 25178322.1548716 21707552.924766168 17945201.074118353 1.0 0.8621524814577887 0.7127242619161677 24.58567881146634 -6.970095054384385 0.2559305253390845 1.0440924192296404 0.5263745283302603 0.9999831044886826 0.0004821647496124952 0.07627205893285877 0.00892091120699275 0.003203282550496856 0.014186587565248007 1.0712848066043261e-07 6.970095054384385 -0.51771789089938 QVVNIPSFIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QVVNIPSFIVR 11 0 P46781 P46781 RPS9 40S ribosomal protein S9 0 41469100.0 21608000.0 8973100.0 10888000.0 False True 17968009.396706503 8924760.129279103 13164630.459576 1.0 0.49670277503945387 0.7326705017189632 24.098927251547234 -10.048369143923058 4.9584606897907335 1.000007362535018 0.6146866383760327 0.7804697317019618 0.09633342103251827 7.843774677026752e-06 1.5053127783285516e-06 0.09327621640813052 0.03109147794361087 8.94604042013461e-11 10.048369143923058 -0.38532072415898544 QVVNIPSFIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QVVNIPSFIVR 11 0 P46781 P46781 RPS9 40S ribosomal protein S9 0 17563300.0 5923500.0 8364200.0 3275600.0 False True 7668087.51964133 7898724.917277296 2679474.410494244 1.0 1.0300775645876763 0.34943190249601835 22.870435372609837 -6.89656216050911 0.9827539351778763 1.0310294055045401 0.28277372468239925 0.9847766814083321 0.03874346961800428 0.11397997131320513 0.19203809701556457 0.029748631157757867 0.0761478688021055 1.2689305095985328e-07 6.89656216050911 -0.7482556808221409 down QVVQGLLSETYLEAHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QVVQGLLSETYLEAHR 16 0 P33993;P33993-3;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 0 23132200.0 7860100.0 8188500.0 7083600.0 False True 10304667.21731667 6966807.718523002 6350657.022689214 1.0 0.6760827469338845 0.6162893850678781 23.296794578920906 -13.999999999999998 0.2376122405976367 3.1194851672651125 0.5892458687089084 0.9995210808692638 0.0036889383140539414 13.540388224164621 0.15429386007933 13.598526045965459 0.029633076591672056 1.0000000000000041e-14 13.999999999999998 -2.530239298556204 QVVQGLLSETYLEAHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QVVQGLLSETYLEAHR 16 0 P33993;P33993-3;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 0 17144200.0 7860100.0 9284100.0 0.0 False True 10766191.381215664 8873897.763586892 0.0 1.0 0.8242374159416899 0.0 23.360004640443798 -7.214202006388019 0.8807851777521901 0.9901987762023351 1.0063625642233581e-15 0.9892062912573106 0.045289250502507435 0.09437921769171892 0.1396985169643129 0.038222422183682436 0.06714537103919205 6.106579193065275e-08 7.214202006388019 -0.9901987762023341 down QWDSVVLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 QWDSVVLER 9 0 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 0 19006100.0 9423000.0 2966500.0 6616600.0 False True 12353644.252461808 2523909.7633264298 5931977.702908894 1.0 0.204304876500185 0.4801803890157175 23.55843335536608 -10.36279463371684 5.807178301793933 1.0001311295419697 0.342242632772441 0.8834438769390354 0.1126257063653133 0.00019124510952522034 2.098469513982523e-05 0.10907077237856404 0.036349790425641335 4.3371592260162606e-11 10.36279463371684 -0.6578884967695287 QWDSVVLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 QWDSVVLER 9 0 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 0 5855840.0 1963400.0 560940.0 3331500.0 False True 1901072.9417108237 784926.2672634555 2458880.207142318 1.0 0.41288592880454156 1.293417076847935 20.858382456716022 -6.726961680119994 1.734067125240903 0.6454920067621223 1.2926324620799783 0.5452246743287132 0.24687353902168682 0.34196718773610024 2.01303139690478 0.11288020840579062 0.2810990370172132 1.8751599551026983e-07 6.726961680119994 0.647140455317856 QWDSVVLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QWDSVVLER 9 0 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 0 15011200.0 9423000.0 2382500.0 3205700.0 False True 12906937.747000072 2277233.2721260814 2448579.683463911 1.0 0.17643482263291874 0.1897103504689196 23.621643416888972 -10.613793931497408 6.428447321918716 1.0026883022946307 0.18307258655092104 0.9998019784736323 0.005419711544052778 0.00020917012662892084 1.2566441358659096e-05 0.005256531487533216 0.0017492043792803758 2.4333583400295538e-11 10.613793931497408 -0.8196157157437096 QWFINITDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QWFINITDIK 10 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 5355300.0 1445500.0 1966600.0 1943200.0 False True 1895064.4982419105 1673190.945746761 1742136.30449061 1.0 0.8829203160626005 0.9193018528429111 20.853815520470008 -10.035996184193632 4.983911700786198 1.0000015510926001 0.9011110844519258 0.9078409577174952 0.014852700197886412 2.5598294306481647e-07 4.9534401743681273e-08 0.014381290563463945 0.004793688375640802 9.204576590600878e-11 10.035996184193632 -0.09889046664067436 QWFINITDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QWFINITDIK 10 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 4743970.0 1535000.0 867170.0 2341800.0 False True 1486272.2652165198 1213435.50323181 1728412.327505893 1.0 0.8164288143094945 1.1629177021977857 20.503266991861533 -6.762765987318614 1.6020815010144236 0.8937392914031748 1.1643587441348764 0.7021559434796734 0.07724407631287508 0.27829123037753 1.4083698307651198 0.038031127086469045 0.09114609388257117 1.726768082904516e-07 6.762765987318614 0.2706194527317016 QWFINITDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QWFINITDIK 10 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 6610900.0 1445500.0 2322400.0 2843000.0 False True 1979940.4131686918 2219788.6888502035 2171541.9534229366 1.0 1.1211391383731892 1.0967713669461427 20.9170255819929 -10.121443312384347 4.452910858068687 0.9999866613161269 1.1089552526643573 0.9638421494198547 0.009948101043414311 1.3175003155954348e-06 2.599590395843343e-07 0.00963338648315038 0.0032107358033983137 7.560607410393136e-11 10.121443312384347 0.10896859134823045 QWGWTQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QWGWTQGR 8 0 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 10210900.0 2905300.0 3980600.0 3325000.0 False True 3808876.43496522 3386709.996257271 2980960.8956521605 1.0 0.8891624745732126 0.7826352328700263 21.860934055032075 -6.971608656394658 0.21634237382710125 1.0514520543324226 0.6173503136448821 0.9999923539122181 0.00024532476485802896 0.07578412357213579 0.007132134428020929 0.003035083199770845 0.010882421062879278 1.0675576662369632e-07 6.971608656394658 -0.4341017406875405 QWGWTQGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QWGWTQGR 8 0 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 5865000.0 2462400.0 1421700.0 1980900.0 False True 2384232.459849617 1989392.224067557 1462042.8642738168 1.0 0.8343952435716087 0.6132132201429863 21.18509347304484 -6.967114418971813 0.3196899400398215 1.0304012497219939 0.41007635545161825 0.9999503301054746 0.0011166733499602417 0.07725059025007598 0.01236750970324532 0.0033569072422049485 0.0194610201192618 1.0786625009954415e-07 6.967114418971813 -0.6203248942703756 QWGWTQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QWGWTQGR 8 0 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 11385700.0 2905300.0 3978500.0 4501900.0 False True 3979467.922780355 3802716.7148598563 3438643.9395408733 1.0 0.9555842109170698 0.8640964084309991 21.924144116554967 -6.959465547254177 0.44291707054202584 1.0031734883272891 0.8129229195126645 0.9997498078095327 0.0008949474973376427 0.07989282629470415 0.02184238022519091 0.0012107229739831574 0.007576267531808318 1.0978283779605586e-07 6.959465547254177 -0.19025056881462465 QWGWTQGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QWGWTQGR 8 0 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 17880100.0 4628100.0 6047600.0 7204400.0 False True 5991166.683489832 5711045.743732345 5893273.123386479 1.0 0.9532443421196358 0.9836603511010429 22.514405541384882 -10.001820784885066 4.685718674389759 1.0000006634070286 0.9684523466087724 0.5892200661248247 0.012417283674762414 8.605469154933288e-08 1.8334244790830196e-08 0.012023236101167473 0.004007661072364154 9.958162641758829e-11 10.001820784885066 -0.031548316798256204 QWHLEGSFPVLATEPPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QWHLEGSFPVLATEPPK 17 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 27135400.0 5111400.0 10861000.0 11163000.0 False True 6701094.898868008 9240581.135846417 10007959.843057157 1.0 1.3789658668178832 1.493481288370915 22.675965407598085 -12.220949631176566 0.19463063221830187 2.726877539305003e-09 1.57933424602022 0.9994253058624225 0.005055498390539165 5.845411192962348 0.12548076894352914 2.3977854515031143 0.07550980389311905 6.012434647561414e-13 12.220949631176566 1.5793342432933424 QWHLEGSFPVLATEPPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QWHLEGSFPVLATEPPK 17 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 25892800.0 10586000.0 5189800.0 10117000.0 False True 10249953.224483442 7262114.204449475 7467054.19650574 1.0 0.7085021800004807 0.7284964168099461 23.289113990238867 -10.439078706633444 5.976865444907594 1.000125005288273 0.7184992984052135 0.9962306014559297 0.008162612996594225 1.3602674624485422e-05 1.2765899277731435e-06 0.007906902135968587 0.002634472016445428 3.6384909024652255e-11 10.439078706633444 -0.28162570688305955 QWHLEGSFPVLATEPPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QWHLEGSFPVLATEPPK 17 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 25496100.0 5111400.0 9009700.0 11375000.0 False True 7001222.710391182 8611621.662906334 8688459.275478678 1.0 1.2300168155092401 1.2409917002901945 22.739175469120976 -12.34456231734943 0.45980079916469896 5.917683877643132e-14 1.2408800714375527 0.9998700183591708 0.0012667251760955167 8.128820037154162 0.2304291939098398 7.904308610622619 0.002424060216631592 4.5231155503853634e-13 12.34456231734943 1.2408800714374935 QWHLEGSFPVLATEPPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QWHLEGSFPVLATEPPK 17 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 22026000.0 10586000.0 4987200.0 6452800.0 False True 8802728.03931577 4960332.963718308 7802050.645623803 1.0 0.5634995130559403 0.8863219005264477 23.069519265673144 -9.851551182476681 5.730817983622079 1.0000000720978892 0.7249107067904168 0.49191795138498806 0.13179168781104847 1.2130945780829951e-07 2.438735622149949e-08 0.12760678628992733 0.042535584337995584 1.4075013417282744e-10 9.851551182476681 -0.2750893653074724 QWTFNYILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QWTFNYILR 9 0 G3V154;Q3YEC7;Q3YEC7-2;F2Z2T0;Q3YEC7-3;H0Y7H6;Q3YEC7-4;Q3YEC7-5;Q3YEC7-6 G3V154 RABL6 Rab-like protein 6 0 3957400.0 1424100.0 1212700.0 1320600.0 False True 1867008.891004017 1031769.8870675752 1183956.9800896968 1.0 0.552632551477954 0.6341464070120217 20.832297367256185 -10.817145195144693 7.26939861775123 1.0190517180569136 0.5933894792449879 0.9707402924906167 0.03327789217090146 0.009764242949057918 0.0002456099710679213 0.030618909842207904 0.01074039351456563 1.5235433112808046e-11 10.817145195144693 -0.4256622388119258 QWTFNYILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QWTFNYILR 9 0 G3V154;Q3YEC7;Q3YEC7-2;F2Z2T0;Q3YEC7-3;H0Y7H6;Q3YEC7-4;Q3YEC7-5;Q3YEC7-6 G3V154 RABL6 Rab-like protein 6 0 6587500.0 2153000.0 1827300.0 2607200.0 False True 2084654.1934926186 2556950.4192436165 1924296.1056765607 1.0 1.226558547324204 0.9230768880917392 20.991376655771226 -6.706873982324552 1.806530832822675 1.139726770036681 0.9238588948417402 0.45017896667389157 0.09551855760340042 0.38138408030961024 2.424307805099003 0.04210988265936413 0.1073790613301699 1.9639300607226694e-07 6.706873982324552 -0.21586787519494088 QWTFNYILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QWTFNYILR 9 0 G3V154;Q3YEC7;Q3YEC7-2;F2Z2T0;Q3YEC7-3;H0Y7H6;Q3YEC7-4;Q3YEC7-5;Q3YEC7-6 G3V154 RABL6 Rab-like protein 6 0 5655000.0 1424100.0 1782100.0 2448800.0 False True 1950628.2548554384 1703360.9293833738 1870443.8746190947 1.0 0.8732370840745411 0.9588930489257749 20.895507428779077 -10.145997344128185 4.889741103619668 1.0000055987471417 0.9160650664998394 0.5614596564909959 0.034968901219649254 2.134471744109639e-06 3.7279292819024685e-07 0.033860751554378045 0.011286164338082624 7.145006954988787e-11 10.145997344128185 -0.08394053224730225 QWTFNYILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QWTFNYILR 9 0 G3V154;Q3YEC7;Q3YEC7-2;F2Z2T0;Q3YEC7-3;H0Y7H6;Q3YEC7-4;Q3YEC7-5;Q3YEC7-6 G3V154 RABL6 Rab-like protein 6 0 2792780.0 2153000.0 639780.0 0.0 False True 1790314.8940720633 636333.3781536125 0.0 1.0 0.3554309804719744 0.0 20.771781931205503 -8.472681989808498 0.5153041294453242 1.0482602862879822 3.0571525039626597e-19 0.9932815701035409 0.03392553548690249 0.21038395907946938 0.1831369087332833 0.0763039542161071 0.0673669170762455 3.3675806870474008e-09 8.472681989808498 -1.0482602862879822 QWVAAGGHITFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QWVAAGGHITFK 12 0 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 0 9429200.0 2885200.0 2866300.0 3677700.0 False True 3782525.1403165455 2438659.2127498947 3297166.882989456 1.0 0.6447172516468225 0.8716840630736769 21.850918240580324 -10.757040945054761 5.812548052926616 1.0093593120233995 0.7582006573605176 0.6021163095733073 0.09265881275704727 0.011493496104983767 0.0004804167669378878 0.09175411268772947 0.02990550322394959 1.7496817217781186e-11 10.757040945054761 -0.2511586546628819 QWVAAGGHITFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QWVAAGGHITFK 12 0 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 0 7233500.0 1848700.0 1252700.0 4132100.0 False True 1790014.030427219 1752909.6427441994 3049779.0496571483 1.0 0.9792714542722528 1.7037738240125768 20.771539464941327 -6.900316500438745 0.9592929389343318 0.9701380125597691 1.7803054638271603 0.9867220181888224 0.038804236476924776 0.11117245851688659 0.17612211491392687 0.030320956384652403 0.07901350000532166 1.2580082799681003e-07 6.900316500438745 0.8101674512673912 QWVAAGGHITFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QWVAAGGHITFK 12 0 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 0 21404400.0 5550100.0 9899200.0 5955100.0 False True 8419907.46666029 8132610.417197384 4778071.874786948 1.0 0.9658788352959347 0.5674732048667209 23.005372947731775 -6.92379295316688 0.7960964520226504 1.0076481551814742 0.4972676190704048 0.9951711309347379 0.013644192578387719 0.09599137036743222 0.09442627903694989 0.011998473341691539 0.037354402733025927 1.1918100596547701e-07 6.92379295316688 -0.5103805361110694 QWVAAGGHITFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QWVAAGGHITFK 12 0 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 0 10180100.0 2885200.0 3577100.0 3717800.0 False True 3951936.4095982816 3419051.894112153 2839732.2104944726 1.0 0.8651586310468248 0.7185672835214305 21.914128302103215 -6.970056305440594 0.25684575533366555 1.0427733875133294 0.5366212260267718 0.9999828135836043 0.0004764154846424881 0.07628451709388656 0.00896513596245976 0.00312361521179399 0.013897588548660014 1.0713803938346713e-07 6.970056305440594 -0.5061521614865576 QWVAAGGHITFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QWVAAGGHITFK 12 0 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 0 3033700.0 1848700.0 0.0 1185000.0 False True 1537275.9612963411 0.0 1432778.0211790549 1.0 0.0 0.9320239548732902 20.551944740375603 -10.035451263996915 16.58392922021222 1.0000000037169574 0.46601199066428944 0.3044304942213967 0.38049718624838946 0.0 0.0 0.36841481640469875 0.12280493880156622 9.216133052660412e-11 10.035451263996915 -0.533988013052668 QWVAAGGHITFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QWVAAGGHITFK 12 0 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 0 30443100.0 5550100.0 13951000.0 10942000.0 False True 7184713.8588269465 13174614.586085398 8950668.274401037 1.0 1.8337006657404205 1.245793284224463 22.776499269824225 -10.13877515362947 5.557808310572875 0.9999911760783688 1.5397469749825226 0.5291529364738876 0.24001218345526162 2.624312400249392e-05 4.0668979820130296e-06 0.23239459317635505 0.07746359911738412 7.26481980078705e-11 10.13877515362947 0.5397557989041537 QWVDTDDTSSENTVVPPETYVK(ub)VAGHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QWVDTDDTSSENTVVPPETYVKVAGHLR 28 1 P15927;P15927-2;P15927-3;Q5TEJ7 P15927 RPA2 Replication protein A 32 kDa subunit 1 36775200.0 9399200.0 10410000.0 16966000.0 True False 9100827.540861966 14566767.287432848 12522095.630909992 1.0 1.6005981018791162 1.375929339907477 23.117566305274597 -10.096571261738168 4.53302738436687 0.9999636474352993 1.4882637209009557 0.8629651592036588 0.09172063807286743 63823815.91956887 2.1022887810952144 26119.894674179624 0.03139841402660888 8.006242463249707e-11 10.096571261738168 0.4883000734656564 QWVDTDDTSSENTVVPPETYVK(ub)VAGHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QWVDTDDTSSENTVVPPETYVKVAGHLR 28 1 P15927;P15927-2;P15927-3;Q5TEJ7 P15927 RPA2 Replication protein A 32 kDa subunit 1 169132000.0 34259000.0 73132000.0 61741000.0 True False 51973407.66838697 60081023.21707604 49537864.28795842 1.0 1.155995458300891 0.9531386628337248 25.631270317504665 -6.7013258323711655 1.8265551807506628 1.0967430683809885 0.9537350921859234 0.42370287436608345 0.06583196071777234 0.39276050409136526 2.5485541140984442 0.028745964665740923 0.0737949352668821 1.989180382976545e-07 6.7013258323711655 -0.143007976195065 QWVDTDDTSSENTVVPPETYVK(ub)VAGHLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QWVDTDDTSSENTVVPPETYVKVAGHLR 28 1 P15927;P15927-2;P15927-3;Q5TEJ7 P15927 RPA2 Replication protein A 32 kDa subunit 1 31928200.0 9399200.0 9956000.0 12573000.0 True False 7815851.255161231 9902365.051888736 15201956.169016233 1.0 1.2669592509644636 1.9450160542624906 22.897971580708873 -6.955121377433946 0.4994693299578777 0.9863579448869387 2.2548359914870137 0.9995442962029573 0.008491564506298793 0.08149216721516966 0.027938886828224388 0.009968379459098975 0.05593254618001412 1.1088648643256916e-07 6.955121377433946 1.268478046600075 QWVDTDDTSSENTVVPPETYVK(ub)VAGHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QWVDTDDTSSENTVVPPETYVKVAGHLR 28 1 P15927;P15927-2;P15927-3;Q5TEJ7 P15927 RPA2 Replication protein A 32 kDa subunit 1 125566000.0 34259000.0 45129000.0 46178000.0 True False 44348950.845850006 42617531.478420675 37774077.826292396 1.0 0.9609591808959027 0.8517468193912673 25.402396639597114 -6.953011173014693 0.5247449133345006 1.0017900600050236 0.8060024798609989 0.9994168916190515 0.001515092214117608 0.08229866551518335 0.031128997789224126 0.0017037256007227228 0.009025530239686436 1.1142658667088502e-07 6.953011173014693 -0.19578758014402464 QWYESHYALPLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QWYESHYALPLGR 13 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 97268300.0 26788200.0 26414000.0 44066100.0 False True 35119589.61729779 22473134.160965562 39506562.683878995 1.0 0.6399030969854116 1.1249152713453248 25.065772650868734 -6.707917237180643 1.8031067000627483 0.7781458223642235 1.1236843470693667 0.45501850415941447 0.15179340286798765 0.3792604168743596 2.4024079676663272 0.06703355617572292 0.17069776624556493 1.959218003039357e-07 6.707917237180643 0.34553852470514324 QWYESHYALPLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QWYESHYALPLGR 13 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 64308100.0 21156000.0 9277000.0 33875100.0 False True 20484414.360208914 12981354.478915906 25002195.078783404 1.0 0.6337186043322897 1.2205472238127688 24.28802331164533 -6.737962821507547 1.6945328471600856 0.7815478711993413 1.2207157109737874 0.5956181979684612 0.1539041352383718 0.3215051475976826 1.811943967573779 0.07188005962770604 0.17675743547851527 1.8282567203632096e-07 6.737962821507547 0.43916783977444607 QWYESHYALPLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QWYESHYALPLGR 13 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 100453900.0 20811500.0 71237000.0 8405400.0 False True 31572567.024450056 58524200.77277851 6744069.005782308 1.0 1.853640875240106 0.2136053429092302 24.91216822872322 -6.765255494419016 1.592644368371074 1.492586851576107 0.20599568671833068 0.7120747353591284 0.35936781368300036 0.27417131360057256 1.3716943323479096 0.17793879926248246 0.42543340356246373 1.7168980429274128e-07 6.765255494419016 -1.2865911648577764 QWYESHYALPLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QWYESHYALPLGR 13 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 96866800.0 26788200.0 40012100.0 30066500.0 False True 36692521.46388486 38244233.11967927 22965411.93900479 1.0 1.0422895891011934 0.6258880835324666 25.128982712391625 -6.88187983845174 1.0693051596160443 1.0269197082179298 0.5952986533651359 0.9751684969220472 0.029487018982590357 0.12597587607249883 0.26235892400256833 0.02120582087240382 0.05153300358314852 1.3125630115917613e-07 6.88187983845174 -0.4316210548527939 QWYESHYALPLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QWYESHYALPLGR 13 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 46434000.0 21156000.0 13515000.0 11763000.0 False True 17592151.369711347 13442192.01248254 14222588.914033107 1.0 0.7641016570392949 0.8084621724276622 24.068428587079605 -10.46400034953697 6.070936297288256 1.000119075260774 0.7862819147334801 0.9686988210164884 0.018110104571396918 2.9203887374202593e-05 2.578369880294615e-06 0.01754475448139487 0.0058450111169245705 3.43557671391282e-11 10.46400034953697 -0.21383716052729396 QWYESHYALPLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QWYESHYALPLGR 13 0 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 65933900.0 20811500.0 21836800.0 23285600.0 False True 26940897.00599569 20621562.883910067 19047859.730432533 1.0 0.7654371300005617 0.7070239616072708 24.68329455081567 -13.999999996867956 0.19523256003362313 2.280966516517588 0.6672546707755701 0.9994873707744956 0.0028665712526341797 12.440687623847117 0.14011859992810918 6.073774181706058 0.038561504062739074 1.0000000072117978e-14 13.999999996867956 -1.613711845742018 QYADK(ub)LEFMHILTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QYADKLEFMHILTR 14 1 P42574 P42574 CASP3 Caspase-3;Caspase-3 subunit p17;Caspase-3 subunit p12 1 6329900.0 1899100.0 1965600.0 2465200.0 True False 1838814.1100147814 2750474.3304685876 1819490.1655852478 1.0 1.4957870485595077 0.9894910832344123 20.810344211056098 -10.626945794541053 2.895921272866715 0.9798452401925357 1.2426390659221547 0.23443947348240024 0.2066944650526197 50108668.83332579 46640477.50292603 7541441.334043488 0.0729856029236981 2.360772869185801e-11 10.626945794541053 0.26279382572961896 QYADK(ub)LEFMHILTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QYADKLEFMHILTR 14 1 P42574 P42574 CASP3 Caspase-3;Caspase-3 subunit p17;Caspase-3 subunit p12 1 32295500.0 3049500.0 10592000.0 18654000.0 True False 4626314.448312735 8701774.844326282 14967028.723661343 1.0 1.8809302613444077 3.2351948599429883 22.14143189790177 -6.96484564493617 0.3606913318555271 0.8842207902982818 4.278363313841459 0.9999099285704371 0.008724792365063022 0.07801337749121971 0.015044854509397902 0.01814424771277439 0.11562360858275855 1.0843122270995981e-07 6.96484564493617 3.3941425235431772 QYADK(ub)LEFMHILTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QYADKLEFMHILTR 14 1 P42574 P42574 CASP3 Caspase-3;Caspase-3 subunit p17;Caspase-3 subunit p12 1 4846040.0 1899100.0 837440.0 2109500.0 True False 1579185.7943949134 832928.5445011738 2550586.6967740217 1.0 0.5274417661667997 1.6151276853090701 20.590749486490374 -6.788643712778356 1.501951775496135 0.7354207295795419 1.626235033120808 0.7968385833761862 0.2007190278375242 0.23737913664827193 1.0579418054275498 0.1052022635710102 0.24652822679292496 1.6268828732813182e-07 6.788643712778356 0.8908143035412661 QYADK(ub)LEFMHILTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QYADKLEFMHILTR 14 1 P42574 P42574 CASP3 Caspase-3;Caspase-3 subunit p17;Caspase-3 subunit p12 1 28152700.0 3049500.0 9876200.0 15227000.0 True False 3947637.8646317613 9326580.788122477 12455842.242213923 1.0 2.362572532724571 3.1552646593574547 21.91255821999422 -8.743891300582794 0.20848826601454312 3.368359085147232e-12 3.9750087742001456 0.9995775029399918 0.018295290406948484 0.2931220767514694 0.06195135326366524 0.5886660169729174 0.3912101439744161 1.803469074032369e-09 8.743891300582794 3.9750087741967772 QYAHIYATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QYAHIYATR 9 0 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7;C9IZD2;C9JHC7 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 0 5059200.0 1670500.0 1265900.0 2122800.0 False True 2190041.6771450136 1077032.6544395522 1903153.019335458 1.0 0.49178637360161825 0.86900310582968 21.06252689432793 -9.734578957785514 5.96599277364816 1.0000000090182275 0.6803947397140068 0.48905564804856705 0.15399808607231957 1.848795802988462e-08 3.7242461559914725e-09 0.14910801011767208 0.04970266855796985 1.842557468634585e-10 9.734578957785514 -0.31960526930422073 QYAHIYATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QYAHIYATR 9 0 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7;C9IZD2;C9JHC7 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 0 4188000.0 1670500.0 1036100.0 1481400.0 False True 2288128.9935650676 990321.6760754803 1131523.8303906904 1.0 0.4328084993724452 0.4945192485095413 21.125736955850822 -10.114269517458371 5.172825249122441 1.0000140510263016 0.4636638739430992 0.9901685415934789 0.025193307840996746 4.082578742816795e-06 6.990013379389061e-07 0.02439395410700246 0.008131105141640489 7.686532761010923e-11 10.114269517458371 -0.5363501770832024 QYAHIYATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QYAHIYATR 9 0 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7;C9IZD2;C9JHC7 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 0 6186100.0 1816600.0 2003800.0 2365700.0 False True 2351624.5105394544 1892286.7685182358 1935166.8741318325 1.0 0.8046721574968411 0.8229064059584547 21.165226289350095 -10.720091606457924 6.76632275660782 1.0023771366192196 0.813789281727648 0.9928597108628129 0.007444100762347072 0.00026998367856801976 1.11686379815048e-05 0.007289780373778685 0.002402573190005011 1.9050588383485448e-11 10.720091606457924 -0.1885878548915716 QYAK(ub)DIGFIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QYAKDIGFIK 10 1 A0A2R8Y851;P62273;P62273-2;A0A2R8Y6P7;A0A087WTT6 A0A2R8Y851 RPS29 40S ribosomal protein S29 1 7400200.0 3552200.0 1407800.0 2440200.0 True False 5388947.10060551 1156567.0908083953 1957893.4004223435 1.0 0.21461837891829402 0.36331650021250933 22.361571994227994 -9.967827928126237 6.899016188383272 1.000000053816871 0.2889674397399938 0.9682402988714167 0.06070575381355925 5.026100508016849e-08 7.490322532120053e-09 0.058778097763982566 0.01959269779490572 1.076891804557872e-10 9.967827928126237 -0.7110326140768772 QYAK(ub)DIGFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QYAKDIGFIK 10 1 A0A2R8Y851;P62273;P62273-2;A0A2R8Y6P7;A0A087WTT6 A0A2R8Y851 RPS29 40S ribosomal protein S29 1 6176900.0 2290600.0 2287500.0 1598800.0 True False 3137496.7211374715 2186430.6862490717 1221196.368319587 1.0 0.6968710665158563 0.38922634088900443 21.581182520689996 -7.0723333462444415 0.24594785479145462 1.1080828679992405 6.678420433685889e-11 0.9999850861965254 0.0009629306986492526 0.07395153778862651 0.00894691277490343 0.007877577701697195 0.029782023114097035 8.465773673882811e-08 7.0723333462444415 -1.1080828679324564 down QYASLTGTQALPPLFSLGYHQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QYASLTGTQALPPLFSLGYHQSR 23 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 281351000.0 57351000.0 164490000.0 59510000.0 False True 75187716.38787398 139948733.17699814 53352476.0602285 1.0 1.8613244277168737 0.7095903243689019 26.163993648537005 -6.7065659008409435 1.8078771343490807 1.5313799088880318 0.7126091864792574 0.4486213019430224 0.3631586556308234 0.38199996103790107 2.4317006303529944 0.16000235837214538 0.4081172569514119 1.965323735220743e-07 6.7065659008409435 -0.8187707224087744 QYASLTGTQALPPLFSLGYHQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QYASLTGTQALPPLFSLGYHQSR 23 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 420080100.0 193937100.0 81733000.0 144410000.0 False True 187780672.91630125 114369413.13196443 106584688.79286286 1.0 0.6090584901830758 0.567602017489683 27.484473342204147 -13.999999999999998 0.316973735877454 4.937213838355428 0.5590908448662223 0.9996872077576988 0.003445207730844685 17.78175197866556 0.17941781991292272 46.35213891868049 0.01396803762991062 1.0000000000000041e-14 13.999999999999998 -4.378122993489205 QYASLTGTQALPPLFSLGYHQSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QYASLTGTQALPPLFSLGYHQSR 23 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 502611200.0 116270000.0 187171300.0 199169900.0 False True 176390090.47559333 153769119.13895825 159803881.9657317 1.0 0.8717559967476456 0.905968592310708 27.394194272243226 -10.776028105625864 6.901163951860857 1.0031636953959462 0.8888622945291769 0.9336423388927306 0.013967233650951786 0.0006974940052509826 2.2636610733843416e-05 0.013874177967563033 0.004507905276893676 1.67483448460873e-11 10.776028105625864 -0.11430140086676932 QYASLTGTQALPPLFSLGYHQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QYASLTGTQALPPLFSLGYHQSR 23 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 394475580.0 57351000.0 73836280.0 263288300.0 False True 78555214.55249925 70573949.0056736 201105026.13274845 1.0 0.8983992903298395 2.560046806292508 26.227203710059896 -6.892350358982694 1.0083504315464298 0.9156833454268921 2.7097363744643936 0.9823613524832465 0.101001458059695 0.11725783104593505 0.21086234565526005 0.0760738701735343 0.1913353094830431 1.2812965035154485e-07 6.892350358982694 1.7940530290375016 up QYASLTGTQALPPLFSLGYHQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QYASLTGTQALPPLFSLGYHQSR 23 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 363908100.0 193937100.0 80618000.0 89353000.0 False True 161267291.52027053 80183694.83257982 108036299.1784069 1.0 0.4972099058444292 0.6699207146095539 27.264878617638423 -10.084502513920803 5.609764274140339 1.0000030466446979 0.5835653102268943 0.8857356794040631 0.07050889242333763 2.6866141878627633e-06 4.3849806562370973e-07 0.06827044091741587 0.022756647176209698 8.23185071887179e-11 10.084502513920803 -0.4164377364178036 QYASLTGTQALPPLFSLGYHQSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QYASLTGTQALPPLFSLGYHQSR 23 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 456975900.0 116270000.0 193175900.0 147530000.0 False True 150513807.02434334 182425491.34973657 120681053.78563185 1.0 1.21201831882594 0.8017939096186273 27.165320594335675 -6.766203992744526 1.5887542055893744 1.1221929585888046 0.7997969971607699 0.7159468429176818 0.0892745612610149 0.2725958453846827 1.357279774286128 0.04430554472873086 0.10584695294700903 1.7131524325469161e-07 6.766203992744526 -0.3223959614280347 QYATLDVYNPFETR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QYATLDVYNPFETR 14 0 O14828 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 0 8729400.0 1914200.0 3309600.0 3505600.0 False True 2509534.7371391696 2815820.5807197564 3142874.140089685 1.0 1.122048855928469 1.2523732361929816 21.258988485436166 -6.970291951313092 0.25112500227162354 0.9592093289366895 1.4190352110935756 0.9999845651148369 0.000404811668573371 0.07620810802327022 0.008690992882160742 0.002884697198359235 0.012467508036866347 1.0707992262234475e-07 6.970291951313092 0.459825882156886 QYATLDVYNPFETR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QYATLDVYNPFETR 14 0 O14828 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 0 5839700.0 1914200.0 1721300.0 2204200.0 False True 2621931.469309937 1645247.2744220889 1683613.3569239653 1.0 0.6274943848380214 0.6421271404805532 21.322198546959058 -9.782352851074128 6.253088726720968 1.000000008881022 0.6348107626677628 0.9987973054798582 0.005973797476906201 7.401030998493324e-10 1.3783568560043644e-10 0.005784104621137503 0.0019280348449825756 1.6506201745370946e-10 9.782352851074128 -0.3651892462132591 QYATLDVYNPFETR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QYATLDVYNPFETR 14 0 O14828 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 0 5975700.0 2155200.0 1425100.0 2395400.0 False True 1792144.2915485885 1417422.7034397963 2896267.0649217754 1.0 0.7909088069102985 1.616090333005004 20.77325536761321 -6.839543868898578 1.2845803825989117 0.8887634405730089 1.642975504120676 0.9236567260889101 0.09678101326319635 0.16933199414319977 0.5429896227446966 0.059082512773597766 0.1360932582551799 1.4469586857073094e-07 6.839543868898578 0.754212063547667 QYFEQFGK(ub)VEDAMLMFDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QYFEQFGKVEDAMLMFDK 18 1 Q96DH6;B4DHE8;Q96DH6-2;B4DM51;Q96DH6-3 Q96DH6 MSI2 RNA-binding protein Musashi homolog 2 1 16133300.0 3915800.0 5433000.0 6784500.0 True False 5069080.291957719 5130648.7740091635 5549790.614848638 1.0 1.012145888110931 1.0948318620349302 22.273292585074767 -6.9332253534684805 0.7198296363856653 0.9988806160036552 1.113290469688258 0.9971349477438953 0.0022552725379759277 0.09099744319670497 0.06972823780063439 0.0020955974451881357 0.0073534828509725725 1.1662043218140162e-07 6.9332253534684805 0.11440985368460277 QYFQTAEK(ub)NVQLSLLTER ddPTM_RPMI8226_Bortezomib_1h_R1 1 QYFQTAEKNVQLSLLTER 18 1 F8W7U8;P49959-2;P49959;P49959-3 F8W7U8 MRE11A Double-strand break repair protein MRE11A 1 7523200.0 1977600.0 3509300.0 2036300.0 True False 2592652.75110564 2985726.1191442595 1825603.2095688672 1.0 1.151610495416709 0.7041448989998126 21.30599756000997 -6.8152887468206975 1.3920896646074783 1.0821273682313919 0.6953258367643395 0.8732066168968561 0.06616474269003411 0.19967920075529946 0.7615802937876699 0.03736066330703647 0.08623886484463324 1.5300698348858007e-07 6.8152887468206975 -0.38680153146705243 QYFQTAEK(ub)NVQLSLLTER ddPTM_RPMI8226_Bortezomib_2h_R1 1 QYFQTAEKNVQLSLLTER 18 1 F8W7U8;P49959-2;P49959;P49959-3 F8W7U8 MRE11A Double-strand break repair protein MRE11A 1 17163900.0 6869300.0 6016700.0 4277900.0 True False 6651237.831564717 8419199.686675997 3157389.655750902 1.0 1.26580944778746 0.4747070749397815 22.665191428325183 -6.816074130392459 1.3886567016734366 1.143864588796863 0.45883164606729177 0.8751430746330207 0.11614868590088245 0.19863038167669136 0.7536514037682839 0.06574270151446338 0.1517162595778228 1.527305337892324e-07 6.816074130392459 -0.6850329427295713 down QYFQTAEK(ub)NVQLSLLTER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QYFQTAEKNVQLSLLTER 18 1 F8W7U8;P49959-2;P49959;P49959-3 F8W7U8 MRE11A Double-strand break repair protein MRE11A 1 7868300.0 1977600.0 3634100.0 2256600.0 True False 2708772.1626305124 3473533.445638361 1723637.5561358423 1.0 1.2823276514571023 0.6363169187555453 21.369207621532862 -6.787939002703964 1.504770187875278 1.1582173353676868 0.6298511468497578 0.7945102622237049 0.1198682356076006 0.23843919832180113 1.0666650781528924 0.06271125706635902 0.14703250184088984 1.629524885724717e-07 6.787939002703964 -0.5283661885179289 QYFQTAEK(ub)NVQLSLLTER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QYFQTAEKNVQLSLLTER 18 1 F8W7U8;P49959-2;P49959;P49959-3 F8W7U8 MRE11A Double-strand break repair protein MRE11A 1 15429800.0 6869300.0 5941900.0 2618600.0 True False 5712127.311588117 5909889.805325189 3166137.1529615778 1.0 1.0346215136584707 0.5542833659429259 22.44559670375946 -6.889577798969134 1.0248991403464316 1.0260710664316681 0.5133133255674717 0.9806258781797897 0.030445285985098526 0.11948549573870233 0.22386489331812331 0.022646983025431368 0.056373001556065006 1.2895025373387542e-07 6.889577798969134 -0.5127577408641965 QYFVQWCADR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QYFVQWCADR 10 0 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YFV6;A0A2R8YF18 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 9621500.0 2443200.0 3391000.0 3787300.0 False True 3203058.8599824575 2885076.0180144743 3395426.526346893 1.0 0.9007252579898813 1.0600574871625958 21.61101887890245 -6.738225015381873 1.6933140584398052 0.940810676504986 1.060113124849016 0.596907899291485 0.04171301346039474 0.32103132527744227 1.8067284526432181 0.019493939686862548 0.04792768803918532 1.827153291556144e-07 6.738225015381873 0.11930244834403014 QYFVQWCADR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QYFVQWCADR 10 0 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YFV6;A0A2R8YF18 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 10411400.0 2443200.0 3253400.0 4714800.0 False True 3346517.0649974085 3109654.030444911 3601261.344354007 1.0 0.9292210289228928 1.076122211364488 21.67422894042534 -6.7756892666043145 1.5526467996616113 0.9596987230761124 1.0771327783031863 0.7518469406663627 0.029881694249401857 0.25733075434596286 1.2249626457227563 0.015163145900053313 0.035910007007250486 1.6761417098725644e-07 6.7756892666043145 0.11743405522707395 QYGLDNSGGYK(ub)QQQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QYGLDNSGGYKQQQLR 16 1 Q96AP4 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 24016700.0 7068100.0 8791900.0 8156700.0 True False 9266347.547577761 7480182.790557791 7312722.928591261 1.0 0.8072417694405519 0.7891699389694075 23.14356936304479 -13.999999999843054 0.33485312729058714 3.160754219287745 0.786148447801037 0.9997248214067215 0.0015827379173875146 19.24154098856649 0.18531340084369222 29.353519117280086 0.005688298044283003 1.0000000003613825e-14 13.999999999843054 -2.374605771486708 QYGLDNSGGYK(ub)QQQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QYGLDNSGGYKQQQLR 16 1 Q96AP4 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 51661000.0 10939000.0 15427000.0 25295000.0 True False 10591747.432705875 21587081.550742205 18669480.666265927 1.0 2.0381038811484715 1.7626440570719342 23.33643728985232 -10.314123831326159 6.614417077309791 0.9999738331233397 1.9003739691102028 0.9344055147980238 0.11245600227072301 4.339487835468221e-05 4.4999138759188515e-06 0.10888820413541045 0.0362950186646311 4.851501485262889e-11 10.314123831326159 0.9004001359868632 QYGLDNSGGYK(ub)QQQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QYGLDNSGGYKQQQLR 16 1 Q96AP4 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 85353000.0 11808000.0 20169000.0 53376000.0 True False 17913599.280431807 16569684.368883723 42826210.20446815 1.0 0.9249779516383327 2.3907094009437855 24.09455190339628 -6.8948386576194824 0.9933017179131359 0.9301343869404878 2.5294154278521375 0.9838194481558676 0.08573034095900008 0.11530560123035408 0.1996092264148179 0.06530734401512704 0.16592282612304712 1.2739762811113031e-07 6.8948386576194824 1.5992810409116496 up QYGLDNSGGYK(ub)QQQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QYGLDNSGGYKQQQLR 16 1 Q96AP4 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 21051900.0 7068100.0 5665000.0 8318800.0 True False 9681367.578220433 5414701.568350152 6354070.77106391 1.0 0.5592909808043306 0.6563195457383795 23.20677942456768 -10.550535432010593 15.352964858711593 1.0000000493046686 0.6078052632713686 0.9561100728199972 0.03961174576048738 6.684524346301377e-08 1.9357128692906896e-09 0.038353913054686266 0.012784635970380832 2.814910350686248e-11 10.550535432010593 -0.39219478603329994 QYGLDNSGGYK(ub)QQQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QYGLDNSGGYKQQQLR 16 1 Q96AP4 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 56071000.0 10939000.0 27646000.0 17486000.0 True False 9096263.1798673 27497065.51069865 21142241.753870863 1.0 3.022896871712961 2.3242777100672343 23.116842565286596 -10.194394901431648 5.469040440360103 0.9999342703217926 2.6735872908902913 0.8844149684375012 0.2852100784278465 0.00022858924614317818 3.3671093565524615e-05 0.27616412527388223 0.09205115699336464 6.391533927306831e-11 10.194394901431648 1.6736530205684987 QYGLDNSGGYK(ub)QQQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QYGLDNSGGYKQQQLR 16 1 Q96AP4 Q96AP4 ZUFSP Zinc finger with UFM1-specific peptidase domain protein 1 66154000.0 11808000.0 32120000.0 22226000.0 True False 15285688.770477736 30332493.764250763 18181096.058018398 1.0 1.9843720632879769 1.1894194845267787 23.86567822548873 -10.098393773803709 4.428121321673616 0.9999437818163458 1.5868957732733642 0.4208735627048289 0.32453803140774906 49098315.857407406 55984723.100118846 22956.620981967015 0.11109800321092178 7.972714752449357e-11 10.098393773803709 0.5869519914570184 QYIGPPSAAAIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QYIGPPSAAAIFK 13 0 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 6836800.0 1727500.0 2238300.0 2871000.0 False True 2264769.229133799 1904354.3648250625 2573936.460576647 1.0 0.8408602255486385 1.1365115824896181 21.11093262226858 -6.760510788447487 1.6104906518751805 0.9076185981780721 1.1376200439424058 0.6930165542237994 0.06693994052356093 0.28208899831221196 1.4421145926959185 0.032792606518463024 0.07876789686866537 1.7357581438152392e-07 6.760510788447487 0.23000144576433368 QYIGPPSAAAIFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QYIGPPSAAAIFK 13 0 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 6141300.0 1727500.0 1410400.0 3003400.0 False True 2366203.433932149 1348083.8644309011 2294058.7769646277 1.0 0.5697244138432594 0.9695103743266776 21.174142683791473 -10.501134129502637 9.002220071652035 1.0000074395956862 0.7696173940849685 0.3068912043961637 0.16321193491880895 2.4370652370084394e-05 1.3503740330283057e-06 0.15803437572127377 0.05267642548690296 3.154030367709397e-11 10.501134129502637 -0.23039004551071762 QYIISEELISEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QYIISEELISEGK 13 0 A6NFX8;Q9UKK9;A6NJU6;A6NCQ0;C9JYY9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 14429600.0 2176100.0 7619900.0 4633600.0 False True 2852888.173382377 6483040.622137571 4154159.5206297273 1.0 2.2724482097212015 1.4561242040218374 21.44399176704347 -10.138452297416698 4.946950704282069 0.9999529987287447 1.8642862068729253 0.5991362238840767 0.33326287980072195 0.0001737692438383384 3.0263800503217368e-05 0.3226979517640554 0.10756013194677509 7.270222504125998e-11 10.138452297416698 0.8643332081441807 QYIISEELISEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QYIISEELISEGK 13 0 A6NFX8;Q9UKK9;A6NJU6;A6NCQ0;C9JYY9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 14280900.0 2176100.0 7843900.0 4260900.0 False True 2980662.976891314 7497330.561691397 3254563.1759900716 1.0 2.515323141132429 1.0918923746905536 21.507201828566362 -6.63139363028252 2.0750975579261324 1.997283967501251 1.0976148158629242 0.12263631646052053 0.6497597658061398 0.5553845147605512 4.559132780759637 0.2559207104398612 0.7198629653842944 2.336718353640745e-07 6.63139363028252 -0.8996691516383268 QYISVK(ub)TQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QYISVKTQR 9 1 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 6957100.0 961400.0 1284700.0 4711000.0 True False 1244551.2520272105 1213205.3156579377 3853646.3389419955 1.0 0.974813462829904 3.096414336223528 20.247194212678867 -6.904215835191591 0.9342486843543355 0.9217019248954736 3.3391888002435484 0.9885490591045616 0.1063936481337742 0.10836771658763697 0.16044275555117277 0.08468783910220075 0.22538499370328802 1.2467637449816433e-07 6.904215835191591 2.4174868753480747 up QYK(ub)IPDWFLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QYKIPDWFLNR 11 1 P62269;J3JS69 P62269 RPS18 40S ribosomal protein S18 1 44488000.0 2766900.0 3126100.0 38595000.0 True False 4197589.587485333 2568223.030669216 30966681.333210558 1.0 0.6118328095548217 7.377253227789212 22.00112968568161 -6.893296075720643 1.0026495181462414 0.6646869746302466 7.998224365619401 0.9829265092641225 0.40529957547603845 0.11651073981169048 0.2065375021773634 0.3065825913568785 0.773989663784737 1.27850939657549e-07 6.893296075720643 7.333537390989155 up QYK(ub)IPDWFLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QYKIPDWFLNR 11 1 P62269;J3JS69 P62269 RPS18 40S ribosomal protein S18 1 84558100.0 2766900.0 5255200.0 76536000.0 True False 3581806.593752954 4962743.500307927 62607233.32567702 1.0 1.3855420080368022 17.47923336644435 21.77225600777406 -6.912056609108555 0.8816258713153962 0.5335340441287805 19.653134944044396 0.9916745292215942 0.7006742374797345 0.10307335418040221 0.1315112641293995 0.5795498496197858 1.6235328232909991 1.2244565842657295e-07 6.912056609108555 19.119600899915614 up QYK(ub)YDLVAVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QYKYDLVAVGK 11 1 O43292;O43292-2;E9PQ31 O43292 GPAA1 Glycosylphosphatidylinositol anchor attachment 1 protein 1 36894900.0 5115200.0 5185700.0 26594000.0 True False 6706076.73566726 4412013.773700277 23842307.98766118 1.0 0.6579128076829676 3.5553288349434387 22.677037560886117 -6.877446720668209 1.0938926702865177 0.7943386013820165 3.750909830211189 0.9715690289809341 0.2179835677095496 0.12991808824673548 0.28613103677611407 0.1538358481766222 0.3697320958839986 1.3260297853751492e-07 6.877446720668209 2.956571228829173 up QYK(ub)YDLVAVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QYKYDLVAVGK 11 1 O43292;O43292-2;E9PQ31 O43292 GPAA1 Glycosylphosphatidylinositol anchor attachment 1 protein 1 63611500.0 5598500.0 11012000.0 47001000.0 True False 5420778.681963965 15409149.026821379 34690028.10022397 1.0 2.842608033065573 6.399454789704801 22.370068675500566 -6.960732363229763 0.4249870935333284 0.8509705748805001 8.526369080473618 0.9997964024990232 0.03197690746954795 0.07944054712807405 0.020172362229704376 0.04617613878311145 0.2956885219017108 1.0946307316948112e-07 6.960732363229763 7.675398505593118 QYK(ub)YDLVAVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QYKYDLVAVGK 11 1 O43292;O43292-2;E9PQ31 O43292 GPAA1 Glycosylphosphatidylinositol anchor attachment 1 protein 1 145953200.0 8175200.0 67748000.0 70030000.0 True False 12402376.087176995 55657840.08246 56188539.80476062 1.0 4.487675562427548 4.5304657276805855 23.56411320746847 -10.367117923557904 0.8636158399841051 3.68959772796036e-09 4.520450629127867 0.9999786566849882 0.007642595662546808 1.757116379871763 0.4734736971327886 4.183981628578017 0.005949506421741056 4.2941981099006335e-11 10.367117923557904 4.5204506254382695 QYK(ub)YDLVAVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QYKYDLVAVGK 11 1 O43292;O43292-2;E9PQ31 O43292 GPAA1 Glycosylphosphatidylinositol anchor attachment 1 protein 1 60551700.0 5115200.0 4252500.0 51184000.0 True False 7006427.673082322 4064610.4888630267 39095393.36756929 1.0 0.5801259469898862 5.57993248367754 22.740247622409008 -6.88650645812798 1.042871698159086 0.7084249409153281 5.981575850423964 0.9785647058150405 0.33153546024044317 0.12202159411731181 0.23879464261668876 0.24327813853882477 0.5993249093426561 1.2986542521913927e-07 6.88650645812798 5.273150909508636 up QYK(ub)YDLVAVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QYKYDLVAVGK 11 1 O43292;O43292-2;E9PQ31 O43292 GPAA1 Glycosylphosphatidylinositol anchor attachment 1 protein 1 49840500.0 5598500.0 11111000.0 33131000.0 True False 4655400.8056026185 11051142.837639187 40058538.919563964 1.0 2.3738327373100736 8.604745454216285 22.150473950934842 -6.942001726507484 0.6406699118449412 0.9317564043481936 10.388829784371191 0.9984145178045567 0.13175714545450118 0.08686516985189936 0.0505391809323431 0.13029180745384394 0.5317320433271618 1.1428737913655326e-07 6.942001726507484 9.457073380022997 QYK(ub)YDLVAVGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QYKYDLVAVGK 11 1 O43292;O43292-2;E9PQ31 O43292 GPAA1 Glycosylphosphatidylinositol anchor attachment 1 protein 1 103674200.0 8175200.0 44060000.0 51439000.0 True False 10582957.557284 41608022.26814722 42077629.808710955 1.0 3.9316062681843986 3.9759802097807637 23.33523952956092 -10.418642855172044 0.8122052374583636 1.553157494947192e-08 3.9663223708470996 0.9999697476923504 0.007659311235986432 1.8187342600032605 0.43369365179444636 3.982399185188563 0.00635080750213835 3.8137932418305125e-11 10.418642855172044 3.9663223553155245 QYLFSLYECR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QYLFSLYECR 10 0 Q15008;Q15008-4;Q15008-3;Q15008-2;H7C531 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 0 4379600.0 1360300.0 1439900.0 1579400.0 False True 1783366.4731639377 1225072.5326862412 1415978.8386745923 1.0 0.6869437948515393 0.7939920706047876 20.766171769588787 -10.890430393968426 10.698205492139635 1.0174579347131423 0.7404679327281636 0.8868421013426185 0.0437022755733678 0.01639358191498705 0.00016790060462220974 0.03812006267168693 0.014104848790585057 1.286973504648704e-11 10.890430393968426 -0.2769900019849787 QYLFSLYECR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QYLFSLYECR 10 0 Q15008;Q15008-4;Q15008-3;Q15008-2;H7C531 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 0 4486000.0 1360300.0 1020000.0 2105700.0 False True 1863239.6707252662 974933.0273110602 1608377.028252787 1.0 0.5232461731193 0.863215319812682 20.82938183111168 -10.024771413521279 5.519913823888608 1.0000012695040001 0.6932307464657552 0.5205294592434646 0.13879182294886547 2.168246024568608e-06 3.8345632301722904e-07 0.13438515937175932 0.04479486823910604 9.445579039073111e-11 10.024771413521279 -0.3067705230382449 QYMFSSLK(ub)NSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 QYMFSSLKNSK 11 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 13865600.0 1552500.0 4905900.0 7407200.0 True False 2355256.0029531126 4030403.81502835 5943163.6733089015 1.0 1.7112381031933985 2.5233620743805045 21.167452450443726 -6.9693945076955215 0.2722582801894495 0.8035593060750168 3.455529799278071 0.999977267794771 0.002967322181935595 0.07649967954112327 0.009731052437403343 0.015702314230108292 0.07529995455067294 1.0730142567189566e-07 6.9693945076955215 2.6519704932030543 QYMFSSLK(ub)NSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QYMFSSLKNSK 11 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 15553400.0 1552500.0 2633900.0 11367000.0 True False 2009741.8543501575 2487321.149615823 9298322.635269295 1.0 1.2376321586933805 4.626625362427889 20.938578772536175 -6.921054076576426 0.8168758689673103 0.9280272500507524 5.186595577186745 0.9944686467819766 0.12319455984449927 0.0975555106906072 0.10243111077579158 0.10674141671626487 0.3230329679875103 1.199349955689858e-07 6.921054076576426 4.258568327135992 up QYPISLVLAPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QYPISLVLAPTR 12 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;A0A2R8YDH3;O15523-3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 27456800.0 11309000.0 6428300.0 9719500.0 False True 10950001.985233625 8995153.713141652 7173671.371250123 1.0 0.8214750760111149 0.6551296868186886 23.38442779559839 -6.971975696892072 0.20559048656596426 1.0921437403322554 0.37984005229795886 0.9999939664266942 0.00034585753327311326 0.0756666642419607 0.0066845836829164266 0.005160203452055618 0.017417683945785994 1.0666558095915656e-07 6.971975696892072 -0.7123036880342966 QYPISLVLAPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QYPISLVLAPTR 12 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;A0A2R8YDH3;O15523-3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 28013000.0 11309000.0 9352100.0 7351900.0 False True 9403934.57364651 9301718.381053489 8889148.298655096 1.0 0.9891304866284937 0.945258415936448 23.164833071032668 -6.944680206627684 0.6146150819504292 1.0004824567631168 0.9316041035344129 0.998713483728215 0.0008487348906753245 0.08569784316587803 0.04538768770757831 0.0008589968527954592 0.0037053860247929066 1.1358468903190081e-07 6.944680206627684 -0.06887835322870384 QYPK(ub)FNFVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QYPKFNFVGK 10 1 Q07666;Q07666-2;Q5VWX1 Q07666 KHDRBS1;KHDRBS2 KH domain-containing, RNA-binding, signal transduction-associated protein 1;KH domain-containing, RNA-binding, signal transduction-associated protein 2 1 10894800.0 3171900.0 5315500.0 2407400.0 True False 4158391.6167232897 4522448.119656719 2158305.341411429 1.0 1.0875474309512718 0.5190240699629248 21.987594199790806 -6.867604974592514 1.1467665775590412 1.0488591921301322 0.48722033086211186 0.9622297455646103 0.04857438494994119 0.13916785321448782 0.3435655402589821 0.032919902611241454 0.0776269668520405 1.3564226257823492e-07 6.867604974592514 -0.5616388612680203 QYPK(ub)FNFVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 QYPKFNFVGK 10 1 Q07666;Q07666-2;Q5VWX1 Q07666 KHDRBS1;KHDRBS2 KH domain-containing, RNA-binding, signal transduction-associated protein 1;KH domain-containing, RNA-binding, signal transduction-associated protein 2 1 17469300.0 6805400.0 6648700.0 4015200.0 True False 6589366.302087631 9303560.582512457 2963498.666581976 1.0 1.4119052054466785 0.4497395547191064 22.651708297562816 -6.790390808870449 1.494877290190631 1.2301008001582006 0.4394136263045273 0.8025374793400741 0.17514917345540698 0.23478110064722663 1.0364834968757481 0.09222302996102251 0.21584551607992675 1.620351334452336e-07 6.790390808870449 -0.7906871738536733 down QYPK(ub)FNFVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QYPKFNFVGK 10 1 Q07666;Q07666-2;Q5VWX1 Q07666 KHDRBS1;KHDRBS2 KH domain-containing, RNA-binding, signal transduction-associated protein 1;KH domain-containing, RNA-binding, signal transduction-associated protein 2 1 11908800.0 3171900.0 7338600.0 1398300.0 True False 4344637.147374454 7014356.3864950575 1068050.3388924685 1.0 1.614486123595837 0.24583188484173216 22.050804261313697 -6.784614931461036 1.5175664210367097 1.3458411622447541 0.2333070575027965 0.7835183076010472 0.26042419173887216 0.24344729986525454 1.1075778730253278 0.13511539777457074 0.31765191929352316 1.642045052239506e-07 6.784614931461036 -1.1125341047419577 QYPK(ub)FNFVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QYPKFNFVGK 10 1 Q07666;Q07666-2;Q5VWX1 Q07666 KHDRBS1;KHDRBS2 KH domain-containing, RNA-binding, signal transduction-associated protein 1;KH domain-containing, RNA-binding, signal transduction-associated protein 2 1 17558600.0 6805400.0 9458300.0 1294900.0 True False 5658991.630338143 9407346.260574449 1565657.6030588672 1.0 1.6623714744763336 0.2766672413271115 22.432113572997093 -6.7767128244290475 1.5484386227560636 1.3766646098414133 0.2667607236063207 0.7556181300530466 0.27974958620414786 0.2557432008201592 1.2108718634903433 0.14232219503389248 0.33678856094844495 1.672195982030291e-07 6.7767128244290475 -1.1099038862350925 QYSGEEGFMK(ub)HNTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QYSGEEGFMKHNTSR 15 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;E7ERV5 G3V394 MYO5A Unconventional myosin-Va 1 3356080.0 1248800.0 1380000.0 727280.0 True False 1710515.1075510632 1319027.0369502576 555511.4428017697 1.0 0.7711285513512375 0.32476266380195434 20.705999415606396 -6.960534099108278 0.42783990387374493 1.0181419452415 0.06069274970159973 0.999789497814688 0.004068097474922143 0.07951087853031329 0.020430413191262924 0.0058088813993858995 0.03708114880779902 1.0951305666116946e-07 6.960534099108278 -0.9574491955399002 down QYTSPEEIDAQLQAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 QYTSPEEIDAQLQAEK 16 0 Q13442;F8WBW6 Q13442 PDAP1 28 kDa heat- and acid-stable phosphoprotein 0 10820600.0 1037100.0 4984700.0 4798800.0 False True 1359648.143290686 4241002.190208421 4302266.209340027 1.0 3.1191909547599153 3.164249685163012 20.37480192108915 -10.540633213715072 0.7261856053973932 5.39336033414564e-09 3.1559166749684424 0.9999482382679565 0.007264953464369289 1.9928665051682246 0.37260438235923443 3.728261314998812 0.00686010236254528 2.8798295671281425e-11 10.540633213715072 3.155916669575082 QYTSPEEIDAQLQAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QYTSPEEIDAQLQAEK 16 0 Q13442;F8WBW6 Q13442 PDAP1 28 kDa heat- and acid-stable phosphoprotein 0 8605500.0 1037100.0 4272600.0 3295800.0 False True 1420543.896573678 4083822.4044012097 2517399.9191316566 1.0 2.8748301367182694 1.7721380699347429 20.438011982612043 -10.614881367265717 6.179087160455983 0.9944787536001868 2.3234841033265057 0.6576205545543757 0.4501721511724386 0.03417182442658701 0.0021297943571067855 0.4350012810708206 0.1452924370347685 2.4272730432074775e-11 10.614881367265717 1.329005349726319 QYYLASCGDDCK(ub)VK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QYYLASCGDDCKVK 14 1 C9JVR6;A8MUM1;Q53HC9 C9JVR6 TSSC1 Protein TSSC1 1 23819000.0 2723100.0 2897700.0 18198200.0 True False 3525106.630325877 2736440.4477169802 14886314.32930041 1.0 0.7762716804580777 4.222940152004494 21.74923546732232 -6.8914036173150715 1.0140745602880308 0.8209892192138805 4.527631938639524 0.9817804666612313 0.21255166388483188 0.11801044303785126 0.2152701575316973 0.1594087237841063 0.3994578236660517 1.2840927166931617e-07 6.8914036173150715 3.7066427194256435 up QYYTLLNK(ub)APEYLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QYYTLLNKAPEYLHR 15 1 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4;D6RBM9;D6REX8;D6RBR0;D6RE13;D6RBW8;D6R9X5;D6R9A4 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 12239800.0 4054400.0 6164900.0 2020500.0 True False 5315357.662865446 5245120.950591983 1811438.0420045652 1.0 0.986786079746965 0.34079325548678896 22.341735341246405 -6.9113219737772935 0.8866877583881214 1.0191749796516032 0.2549062399821622 0.9914107783801196 0.028515718896525037 0.10355051115190873 0.1340751680475053 0.02349982089013138 0.06547965490927052 1.2265295792931456e-07 6.9113219737772935 -0.764268739669441 down QYYTLLNK(ub)APEYLHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 QYYTLLNKAPEYLHR 15 1 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4;D6RBM9;D6REX8;D6RBR0;D6RE13;D6RBW8;D6R9X5;D6R9A4 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 33647900.0 20656000.0 6558200.0 6433700.0 True False 31336662.155877292 5387837.970549531 5162076.3750091195 1.0 0.17193400955561008 0.1647296176386468 24.901348182643073 QYYTLLNK(ub)APEYLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QYYTLLNKAPEYLHR 15 1 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4;D6RBM9;D6REX8;D6RBR0;D6RE13;D6RBW8;D6R9X5;D6R9A4 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 12973400.0 4054400.0 6605900.0 2313100.0 True False 5553421.246040224 6314029.495209939 1766793.4197898672 1.0 1.1369621023638454 0.3181450391593561 22.404945402769297 -6.863905858539371 1.1659237948716101 1.0752239464665199 0.27544726658708074 0.9582090635228525 0.07320659483410193 0.14282766513954448 0.36675513873776794 0.048890467581564824 0.11466847168527876 1.368025338564191e-07 6.863905858539371 -0.7997766798794391 down QYYTLLNK(ub)APEYLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 QYYTLLNKAPEYLHR 15 1 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4;D6RBM9;D6REX8;D6RBR0;D6RE13;D6RBW8;D6R9X5;D6R9A4 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 18291200.0 8175500.0 8213700.0 1902000.0 True False 6798290.486059524 8169451.167808196 2299699.406145622 1.0 1.2016919819122696 0.3382761314570703 22.69674057784157 -6.845176258567459 1.2581960616368546 1.1073363773688 0.30685266686846224 0.932974720869615 0.09547656014962624 0.16284892022891712 0.4985353991264628 0.05944616679524555 0.13719927902854073 1.4283141590618707e-07 6.845176258567459 -0.8004837105003378 down QYYTLLNK(ub)APEYLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 QYYTLLNKAPEYLHR 15 1 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4;D6RBM9;D6REX8;D6RBR0;D6RE13;D6RBW8;D6R9X5;D6R9A4 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 1 33717700.0 20656000.0 8676400.0 4385300.0 True False 26739599.190632436 8193550.712831421 3587220.396977781 1.0 0.30642010205230863 0.13415385815635097 24.672474504735522 -13.999999999998481 0.19560707947481323 4.792873551361518 0.017306153100602597 0.9994872902078816 0.008473674867855635 12.447444735968416 0.14025167897022783 18.030995497501177 0.1133947514436837 1.0000000000034972e-14 13.999999999998481 -4.7755673982609155 QYYTLLNQAPDMLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 QYYTLLNQAPDMLHR 15 0 Q13283;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46;E5RH00 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 17165700.0 2749400.0 8384200.0 6032100.0 False True 3604490.025227473 7133310.041355627 5407956.155988981 1.0 1.9790067364399089 1.500338776952974 21.781363726121718 -10.2032196061901 4.8259293832498225 0.9998943587091143 1.7396727566984838 0.7609842993679017 0.19541537616740476 0.00022214472766587606 3.6677546319292005e-05 0.18923688217352594 0.06307004145643354 6.262970899873125e-11 10.2032196061901 0.7397783979893695 QYYTLLNQAPDMLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 QYYTLLNQAPDMLHR 15 0 Q13283;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46;E5RH00 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 12394900.0 4021800.0 1601000.0 6772100.0 False True 3894130.160422021 2240287.6491047074 4998283.851354794 1.0 0.5752986050322261 1.2835430880443686 21.892869675944542 -6.744280276909009 1.6707577211786921 0.7485721185892191 1.2843825312272046 0.6241357511111649 0.17843477219298143 0.31011393940994947 1.701227405084015 0.08443000177300884 0.20623971447529219 1.801854518137247e-07 6.744280276909009 0.5358104126379855 QYYTLLNQAPDMLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 QYYTLLNQAPDMLHR 15 0 Q13283;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46;E5RH00 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 17282600.0 2749400.0 10250000.0 4283200.0 False True 3765927.4797412693 9797121.107782733 3271596.3752729944 1.0 2.6015161365921537 0.8687358938461989 21.84457378764461 -6.663810051819685 1.9591847330164787 2.0276083004565697 0.8758708808625356 0.25202406737313576 0.6812696519560651 0.475461401508584 3.512144983906025 0.2805392481142464 0.7556690057982427 2.1686524049356483e-07 6.663810051819685 -1.151737419594034 RAAAASAAEAGIATTGTEDSDDALLK(ub)MTISQQEFGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RAAAASAAEAGIATTGTEDSDDALLKMTISQQEFGR 36 2 P55036;H0Y3Y9 P55036 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 100130000.0 10572000.0 47992000.0 41566000.0 True False 16038496.916728081 39427452.63679258 33350461.88097501 1.0 2.4583009767997597 2.0794007103116146 23.935035606977454 -10.163639751497872 5.207053695945851 0.9999439692595838 2.268850843556486 0.9373133931525013 0.15468538605289386 0.00010062362398653015 1.61621849848151e-05 0.14978002480403224 0.049924493673306265 6.860570767758252e-11 10.163639751497872 1.2689068742969023 RAAAASAAEAGIATTGTEDSDDALLK(ub)MTISQQEFGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RAAAASAAEAGIATTGTEDSDDALLKMTISQQEFGR 36 2 P55036;H0Y3Y9 P55036 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 102395000.0 10572000.0 59746000.0 32077000.0 True False 13685662.405275298 56421082.57904512 26239315.1378141 1.0 4.122641704014046 1.9172849921900639 23.706161929069903 -9.255390344116936 11.646852974478762 1.0000000402298237 3.0199633481019252 0.5279862851264053 0.9003331074651492 0.0 2.76032543721448e-17 0.8717437698229288 0.29058126093764103 5.554048346953776e-10 9.255390344116936 2.0199633078721018 RAAEDDEDDDVDTKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RAAEDDEDDDVDTKK 15 2 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 20329300.0 249200.0 10891000.0 9189100.0 False True 326703.61325623264 9266105.252785496 8238300.080071343 1.0 28.36242048390851 25.216433935213534 18.317622885129598 -9.63489474273086 9.220845936724459 1.0000000200103583 26.789425489090885 0.9889624823862084 1.2843436303278104 0.0 0.0 1.2435603912983266 0.41452012425594426 2.3179563706532607e-10 9.63489474273086 25.789425469080527 RAAEDDEDDDVDTKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RAAEDDEDDDVDTKK 15 2 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 11153900.0 4742400.0 1500400.0 4911100.0 False True 4591855.107858513 2099517.5444826335 3624735.5801580804 1.0 0.4572264357578517 0.7893837011439447 22.13064568902246 -10.374342751208737 6.2175474125155725 1.0000485217178872 0.6233050684509067 0.6316580094748789 0.13560263575902443 9.121822416617704e-05 9.178754441369672e-06 0.13131353672434962 0.04376556249971093 4.223351699490597e-11 10.374342751208737 -0.37674345326698044 RAAEDDEDDDVDTKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RAAEDDEDDDVDTKK 15 2 B8ZZQ6;P06454-2;P06454;B8ZZA1;B8ZZW7;H7C2N1 B8ZZQ6 PTMA Prothymosin alpha;Prothymosin alpha, N-terminally processed;Thymosin alpha-1 0 23921200.0 249200.0 13448000.0 10224000.0 False True 341335.97437678184 12853822.893410914 7809301.769889588 1.0 37.65739288652386 22.878636757077743 18.38083294665249 -9.843382439715798 11.992150008713292 1.0000000789221792 30.26801706783027 0.8394701641528044 6.033401925028993 0.0 0.0 5.841816729402875 1.947272098051214 1.434225897791411e-10 9.843382439715798 29.26801698890809 RAEAEK(ub)QLQQAQAAGAEQEVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RAEAEKQLQQAQAAGAEQEVEK 22 2 P39748;P39748-2;F5H1Y3 P39748 FEN1 Flap endonuclease 1 1 12472300.0 3790400.0 3338600.0 5343300.0 True False 3670075.826760062 4671720.390569005 3943729.434436007 1.0 1.272922035154024 1.074563475141473 21.80737843995686 -10.385059295638776 4.401383110866443 0.9996585579727907 1.17374275514841 0.5056700159753105 0.08097954302625761 0.0002718508948636312 3.798165575302034e-05 0.07856125226885428 0.026136035126699257 4.1204125792296164e-11 10.385059295638776 0.1740841971756194 RAEAEK(ub)QLQQAQAAGAEQEVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RAEAEKQLQQAQAAGAEQEVEK 22 2 P39748;P39748-2;F5H1Y3 P39748 FEN1 Flap endonuclease 1 1 58896800.0 5892800.0 10043000.0 42961000.0 True False 8939808.421386233 8250748.183682846 34469739.519524775 1.0 0.9229222590436073 3.8557581879567615 23.09181248434826 -6.900864289596565 0.9557806185836243 0.8809383487166519 4.169077688852255 0.986991630118389 0.15565524356404176 0.11077211282984753 0.17385045485318656 0.12194121722696116 0.3186708732433218 1.256422515236468e-07 6.900864289596565 3.288139340135603 up RAEAEK(ub)QLQQAQAAGAEQEVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RAEAEKQLQQAQAAGAEQEVEK 22 2 P39748;P39748-2;F5H1Y3 P39748 FEN1 Flap endonuclease 1 1 11207400.0 3790400.0 4881500.0 2535500.0 True False 3151885.543191241 4855202.390598116 3065661.3271725676 1.0 1.5404120245059059 0.9726436081395987 21.587783715391136 -8.765940981970656 18.630911245212687 1.0000164780500178 1.2565278163227522 0.2139511936720806 0.23179048555615844 0.0 0.0 0.22443017250386482 0.07481005750128826 1.7141902399087515e-09 8.765940981970656 0.2565113382727344 RAEAEK(ub)QLQQAQAAGAEQEVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RAEAEKQLQQAQAAGAEQEVEK 22 2 P39748;P39748-2;F5H1Y3 P39748 FEN1 Flap endonuclease 1 1 89392000.0 5892800.0 9303200.0 74196000.0 True False 7628345.764453867 8785468.741829952 60693089.315249406 1.0 1.15168727442429 7.956258301513235 22.86293880644071 -6.91170781206343 0.8840283887147636 0.8005260649847141 8.868519299166548 0.9915501603703463 0.29820280949487654 0.10329939045232303 0.1327230718631932 0.24622319636106366 0.6880016573618085 1.2254403830621008e-07 6.91170781206343 8.067993234181834 up RAEDGSVIDYELIDQDAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RAEDGSVIDYELIDQDAR 18 1 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33;H0YNA0 P07355 ANXA2 Annexin A2;Annexin 0 21542200.0 1998700.0 10268000.0 9275500.0 False True 2620315.05543833 8736054.424350513 8315760.236878672 1.0 3.333971007119651 3.17357266624093 21.32130885497701 -10.274213121924522 5.3407466820837 0.9997003142542907 3.253771836680478 0.9962156224019282 0.0654823484576354 0.00023369297758691092 3.1758030051594666e-05 0.06341056460186872 0.02113433708715273 5.3184720111360594e-11 10.274213121924522 2.2540715224261874 RAEDGSVIDYELIDQDAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RAEDGSVIDYELIDQDAR 18 1 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33;H0YNA0 P07355 ANXA2 Annexin A2;Annexin 0 23675800.0 9266000.0 2017800.0 12392000.0 False True 8971855.901951969 2823518.06268799 9146163.447968675 1.0 0.31470836062733565 1.019428259651248 23.096975018637263 -10.941426817004647 12.835362369000029 1.0589585922390121 0.6670683101683511 0.22933957152925788 0.2877006940323784 0.1417306474295752 0.0006467757216070912 0.08133774079764484 0.09285499972330975 1.1443877044270266e-11 10.941426817004647 -0.391890282070661 RAEDGSVIDYELIDQDAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RAEDGSVIDYELIDQDAR 18 1 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;H0YM50;H0YNP5;H0YN28;H0YL33;H0YNA0 P07355 ANXA2 Annexin A2;Annexin 0 21471000.0 1998700.0 9120300.0 10352000.0 False True 2737673.402836571 8717334.989201052 7907070.806132333 1.0 3.1842129087307516 2.888244740201524 21.3845189164999 -9.869433976362156 5.914557502897365 0.9999995812105527 3.0362288244681905 0.984401940459449 0.12082849884107026 6.673367139746571e-07 1.279212757492302e-07 0.1169917153389051 0.038997230312159174 1.350722155842703e-10 9.869433976362156 2.0362292432576377 RAEEQMLK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 2 RAEEQMLKER 10 2 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 32183500.0 11292000.0 13581500.0 7310000.0 True False 14803921.351883546 11555193.140272362 6553631.322471355 1.0 0.7805494818305125 0.44269563223784064 23.81947604044265 -6.964821270997141 0.36110865308565165 1.0287466294132115 0.182900694165105 0.9999094105636188 0.002181709620119333 0.07802167603464649 0.015074259641859886 0.004522777121311407 0.028837943980409272 1.0843730837368891e-07 6.964821270997141 -0.8458459352481065 down RAEEQMLK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 2 RAEEQMLKER 10 2 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 37374200.0 13057200.0 15391900.0 8925100.0 True False 12642706.333149914 21537965.937698144 6587348.562739281 1.0 1.7035882484452194 0.5210394348452806 23.59180198812922 -6.745523287467582 1.6663154018822894 1.415931560524161 0.5194553505017927 0.6295227061192759 0.29561084129151227 0.30792082771614526 1.680675241969291 0.14022544154357777 0.3420579349866898 1.796704735810785e-07 6.745523287467582 -0.8964762100223682 RAEEQMLK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 RAEEQMLKER 10 2 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 19955800.0 12163000.0 4837000.0 2955800.0 True False 18452160.23440823 3973799.558346505 2371584.8344268394 1.0 0.21535687463500647 0.12852613484270978 24.137286389821305 -13.999999999999998 0.31080439120490155 8.62041232582988 0.10946204911938429 0.999673763212315 0.007079531381153374 17.327189390505982 0.17741487233712028 85.42995142724747 0.02999106922014658 1.0000000000000041e-14 13.999999999999998 -8.510950276710496 RAEEQMLK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 2 RAEEQMLKER 10 2 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 29059000.0 11292000.0 10162500.0 7604500.0 True False 15466957.554825928 9713487.147106523 5808473.719593631 1.0 0.628015374883845 0.3755408068460948 23.882686101965543 -8.192074077692762 0.17867783906002235 1.3145594243125158 1.2275572326711556e-07 0.999865791863615 0.0029713385354304318 0.08606961006087191 0.03616686965031173 0.10921079157650172 0.11884515678282549 6.425781032989813e-09 8.192074077692762 -1.3145593015567925 down RAEEQMLK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 2 RAEEQMLKER 10 2 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 39842600.0 13057200.0 21719700.0 5065700.0 True False 10857640.332037946 21602691.665077098 6124914.448849562 1.0 1.9896304357525478 0.5641110095327623 23.372207263563496 -6.719981780992149 1.7592679250230145 1.6020892887122653 0.5663192845868203 0.5124709995473231 0.41644141263273426 0.3553582645242774 2.149420449254419 0.18794923799196323 0.4718531323521123 1.9055406552717123e-07 6.719981780992149 -1.035770004125445 RAEEQMLK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RAEEQMLKER 10 2 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 26277300.0 12163000.0 10826000.0 3288300.0 True False 15745243.268573929 10223523.583181163 2689863.1408072496 1.0 0.649308709226893 0.17083655647137388 23.908412711913755 -7.429032897675178 0.4465749444946128 1.0230667912499924 2.0270989879421685e-28 0.998576231539343 0.01282320031491317 0.11332967351409044 0.05087881253057028 0.0171686099230415 0.06314085473577202 3.7236349876422375e-08 7.429032897675178 -1.0230667912499924 down RAEIK(ub)FSSYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RAEIKFSSYR 10 2 Q9H7Z7;X6RJ95 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 5015200.0 1459500.0 1453300.0 2102400.0 True False 1413168.9713899076 2033610.2688593788 1551718.3693519488 1.0 1.439042541996406 1.0980416360442533 20.430502547106258 -9.98288524593676 5.075931181379887 0.9999981541028801 1.268542089023045 0.4526243248633913 0.13921303691103432 2.9081954911146563e-06 5.824836089563652e-07 0.13479336926821114 0.04493081445959581 1.0401949812753685e-10 9.98288524593676 0.26854393492016493 RAEIK(ub)FSSYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RAEIKFSSYR 10 2 Q9H7Z7;X6RJ95 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 19177700.0 4659500.0 7462400.0 7055800.0 True False 7068802.155078924 6130676.416002677 5661218.037333004 1.0 0.8672864626148569 0.8008737425569942 22.7530343329672 -13.99999999606739 0.08983700362027262 1.6800377143680372 0.6341694401110373 0.9998431703042199 0.001036668809173486 12.165215538328429 0.08704716910235846 1.5807836708282315 0.14980233139317764 1.0000000090551707e-14 13.99999999606739 -1.0458682742569998 RAEIK(ub)FSSYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RAEIKFSSYR 10 2 Q9H7Z7;X6RJ95 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 5376370.0 1459500.0 3492200.0 424670.0 True False 1213638.916812899 3473386.825452575 513466.5335477717 1.0 2.8619606518336873 0.42308014882727296 20.210907822540534 -6.702648274144657 1.8213431087040262 2.1531776999897168 0.42993764559303366 0.4302108310642755 0.7855806018364042 0.39002821074994154 2.517180582888035 0.3438547000863634 0.8814511893646744 1.983132472379979e-07 6.702648274144657 -1.723240054396683 RAEIK(ub)FSSYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RAEIKFSSYR 10 2 Q9H7Z7;X6RJ95 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 15556100.0 4659500.0 7141600.0 3755000.0 True False 6031814.602476369 6744163.68202906 3071628.5295536397 1.0 1.1180986363971193 0.509237888096325 22.52416065505965 -6.856406845819287 1.2037933594522285 1.0635567476394137 0.48171916089461253 0.9491192948061987 0.059466324448434346 0.15054692776428363 0.4166147189236907 0.03858183798008993 0.08972585291894143 1.3918523087850792e-07 6.856406845819287 -0.5818375867448011 RAPFDLFENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RAPFDLFENK 10 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 22852400.0 1902700.0 11489000.0 9460700.0 False True 2494458.125773011 9774885.983771242 8481797.517442517 1.0 3.9186410398218614 3.4002565245764877 21.250295020491848 -10.592542765635717 8.716784347647238 0.9992534346956848 3.6594487821991373 0.9722936390932948 0.21162959215186222 0.003070673571901929 0.00014353553875558913 0.2049208824674014 0.0683031571640692 2.555390255523756e-11 10.592542765635717 2.6601953475034525 RAPFDLFENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RAPFDLFENK 10 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 19422600.0 6578000.0 2805600.0 10039000.0 False True 6369184.990615152 3925890.711010718 7409484.736455573 1.0 0.6163882375524384 1.163333259651475 22.602677344439392 -6.718160845537632 1.765704166996467 0.7661626088537533 1.1624074883230395 0.5039349346231838 0.16146246002869472 0.3588995466334387 2.1857288261086203 0.07263236211446113 0.1827457726181721 1.9135470914384024e-07 6.718160845537632 0.3962448794692862 RAPFDLFENK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RAPFDLFENK 10 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 22197600.0 1902700.0 8964900.0 11330000.0 False True 2606179.6085341224 8568801.075040117 8654087.348674579 1.0 3.287878182678186 3.3206028166041004 21.31350508201474 -10.541039900486227 0.7937082748397273 4.0552755438972703e-07 3.3136809459717136 0.9999736485512583 0.005576431988965101 2.0177172473164964 0.42063005044762347 4.1327651862038595 0.004739978375809466 2.8771340680153223e-11 10.541039900486227 3.3136805404441594 RAPFDLFENK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RAPFDLFENKK 11 2 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 10743800.0 5071500.0 4644000.0 1028300.0 True False 4217176.955544106 4618981.850238178 1243312.7756779923 1.0 1.0952781680564387 0.2948211063430651 22.0078461286528 -6.87718581478192 1.0953212721106023 1.0571219258462259 0.24105628528758918 0.9713460622146844 0.06043228616766219 0.13015461940566003 0.28756858687060155 0.04260164472961897 0.10232856956711213 1.326826647719592e-07 6.87718581478192 -0.8160656405586367 down RAPFDLFENK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RAPFDLFENKK 11 2 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 22945500.0 8049400.0 6769500.0 8126600.0 True False 10420106.977395294 6392771.374131255 6647642.1859575445 1.0 0.6135034302430215 0.6379629499369354 23.312866753244986 -10.633917654610132 6.526374595966735 1.0015275336865035 0.6257331900899785 0.9968069502560445 0.009985557100607544 0.00022272898910399204 1.2493464354655548e-05 0.009702815137141513 0.003222824696104686 2.3231772458883565e-11 10.633917654610132 -0.37579434359652497 RAPFDLFENKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RAPFDLFENKK 11 2 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 0 8788630.0 2361200.0 965830.0 5461600.0 False True 2286244.9984555338 1351490.9557369126 4031043.1155120856 1.0 0.5911400382067138 1.7631719777343395 21.124548583164195 -6.812467852217799 1.4041371962538916 0.7778177675843604 1.784854187446502 0.8661758013164302 0.17768359520093419 0.20345241690359273 0.7901057989778839 0.09948826073549251 0.2298900202082545 1.54004052026604e-07 6.812467852217799 1.0070364198621418 RAPSSAQYLEEK(ub)SDQQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RAPSSAQYLEEKSDQQK 17 2 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2;I3L442 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 15694900.0 2157200.0 3033700.0 10504000.0 True False 3272630.112444739 2492312.532593715 8427879.795933258 1.0 0.7615625496802306 2.5752619472285594 21.64201912095908 -6.87380425234882 1.1137339361414325 0.8614781514803601 2.6894718500454604 0.9683366575269418 0.14318902977506295 0.13326164555935488 0.3066353346855707 0.09952671825713472 0.23732686975642356 1.3371980901816206e-07 6.87380425234882 1.8279936985651002 up RAPSSAQYLEEK(ub)SDQQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RAPSSAQYLEEKSDQQK 17 2 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2;I3L442 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 17110000.0 2157200.0 2811800.0 12141000.0 True False 2792537.9247691864 2655320.858229151 9931462.577179952 1.0 0.9508629532573396 3.5564288989918817 21.41314544305153 -6.902602036200188 0.9446587019758266 0.899267768616225 3.8448641571963074 0.9878173205406942 0.13431104940124788 0.10951566156141697 0.16680932927751385 0.10608930580196771 0.27981425977691315 1.2514052245449573e-07 6.902602036200188 2.9455963885800824 up RDDNSAANNSANEK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 RDDNSAANNSANEKER 16 2 D3DQV9;P78344;H0Y3P2;P78344-2;H0YCH5;H0YD77;H0YEC5;H0YEN8;H0YDC0;H0YCF8;H0YEI7;H0YD99 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 1 3892690.0 759490.0 1939100.0 1194100.0 True False 995698.7449116221 1649793.8385526007 1070545.986616012 1.0 1.6569206770457823 1.0751705694989433 19.92534978604358 -10.279114207877733 4.138205939201237 0.999625717493275 1.3660456232387383 0.3454988685959868 0.2374984869656819 22720684.291700825 58775538.93489905 45254.231307005 0.0813020473383313 5.258789560512088e-11 10.279114207877733 0.36641990574546335 RDEEGNEIK(ub)ESNAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RDEEGNEIKESNAR 14 2 Q8WVC0 Q8WVC0 LEO1 RNA polymerase-associated protein LEO1 1 43892900.0 22624000.0 11756000.0 9512900.0 True False 34322262.035949305 9658049.949952774 7632671.145347818 1.0 0.28139316516600466 0.22238252063204111 25.032641302145283 -13.991498274212955 0.35407670050190015 9.999954996419895 0.21461871786831083 0.999762107809588 0.005452067936226468 20.928386368179517 0.19170422908741738 141.90420776601192 0.01737455685807835 1.0197688123649337e-14 13.991498274212955 -9.785336278551584 RDEEGNEIK(ub)ESNAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RDEEGNEIKESNAR 14 2 Q8WVC0 Q8WVC0 LEO1 RNA polymerase-associated protein LEO1 1 41861600.0 22624000.0 9046600.0 10191000.0 True False 29287213.985712096 8543148.757399483 8336342.568490304 1.0 0.2917023367797052 0.28464102364114346 24.803767624237732 RDFNHINVELSLLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RDFNHINVELSLLGK 15 1 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7 P32969 RPL9 60S ribosomal protein L9 0 16924100.0 7625300.0 4877900.0 4420900.0 False True 7383239.025378198 6825670.907912449 3262933.6658428586 1.0 0.9244819088818287 0.4419379698567619 22.81582243448447 -6.934517650586397 0.7087267298785079 1.0062537150201094 0.3304225550505263 0.9973540595160215 0.0127158122027589 0.09035893612267264 0.06667913267269428 0.011913555442195444 0.042629538177522346 1.1627392940192687e-07 6.934517650586397 -0.6758311599695831 down RDFNHINVELSLLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RDFNHINVELSLLGK 15 1 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7 P32969 RPL9 60S ribosomal protein L9 0 194186000.0 40016000.0 84509000.0 69661000.0 False True 60707197.561463304 69427708.67816932 55892472.81649913 1.0 1.1436487182245054 0.9206893920594921 25.855364239516852 -6.732717506280673 1.713103652227055 1.0861827637746644 0.920749131898135 0.5719255707257844 0.060374669644399186 0.3311612028111205 1.9051358091491353 0.02791345630124055 0.06905903355115381 1.8504718963226147e-07 6.732717506280673 -0.16543363187652937 RDFNHINVELSLLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RDFNHINVELSLLGK 15 1 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7 P32969 RPL9 60S ribosomal protein L9 0 15718600.0 7625300.0 3081100.0 5012200.0 False True 6340774.808066744 3064501.5027495353 6060227.846205623 1.0 0.48330079454183916 0.9557550977044306 22.596227709918747 -10.475977791692287 8.997511869837115 1.0000054074629878 0.7195279461231351 0.31967803692456986 0.19287866158842362 2.09224386114204e-05 1.2183448458007769e-06 0.18675755975364164 0.0622513203475617 3.342121300338457e-11 10.475977791692287 -0.28047746133985274 RDFNHINVELSLLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RDFNHINVELSLLGK 15 1 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7 P32969 RPL9 60S ribosomal protein L9 0 142085000.0 40016000.0 58658000.0 43411000.0 False True 51801500.83328562 55393630.73547392 35510643.43447479 1.0 1.069344127957778 0.685513795223034 25.6264905616093 -6.860139254022655 1.1849195098929228 1.0376412121760943 0.6668674796003736 0.9538170124737482 0.0358911747149826 0.14666427390563735 0.3911936040569385 0.023622087040651572 0.05515378435686711 1.379941723296954e-07 6.860139254022655 -0.37077373257572066 RDLDAITDISPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RDLDAITDISPK 12 1 Q9Y2L8 Q9Y2L8 ZKSCAN5 Zinc finger protein with KRAB and SCAN domains 5 0 7169600.0 1864800.0 2450800.0 2854000.0 False True 2444770.858748887 2085150.1931435762 2558695.457501132 1.0 0.8529020974221907 1.0465992951218936 21.221267821234463 -6.7036787671132805 1.8180171834782328 0.9089882717267901 1.0460596060609761 0.4349543122202226 0.06205110849072821 0.38790636342825896 2.495120851858419 0.02720492551398849 0.06964103350154272 1.9784324783882814e-07 6.7036787671132805 0.13707133433418606 RDLDAITDISPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RDLDAITDISPK 12 1 Q9Y2L8 Q9Y2L8 ZKSCAN5 Zinc finger protein with KRAB and SCAN domains 5 0 8055100.0 1864800.0 2346000.0 3844300.0 False True 2554266.954325132 2242345.9628154384 2936355.5158437486 1.0 0.8778823838355976 1.1495883430945333 21.284477882757354 -6.784557810139888 1.518411615571327 0.9312618631141042 1.1520444431381083 0.7830777139603342 0.0517504664342805 0.24356423724468027 1.1094411629071734 0.026837914158851874 0.06308134815493821 1.6422610392144096e-07 6.784557810139888 0.22078258002400408 RDPNNYRPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RDPNNYRPR 9 2 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 8422490.0 372590.0 4496700.0 3553200.0 False True 488469.09816669254 3825809.8879993116 3185548.9487011265 1.0 7.832245483610377 6.521495342606181 18.89790777085397 -10.458777954523818 6.6668665133522955 0.9984776541932832 7.176870413108278 0.9673307544769227 0.5351115042902306 0.012104575021126187 0.0009826584235069474 0.5179624435415012 0.17270649537333846 3.477138946781962e-11 10.458777954523818 6.178392758914995 RDPNNYRPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RDPNNYRPR 9 2 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 4375300.0 1252900.0 700000.0 2422400.0 False True 1213127.3753027858 979513.6504517749 1787900.7695577256 1.0 0.8074285276163166 1.4737947605143125 20.210299607062037 -6.829428951917166 1.3306800246809771 0.8970650171661635 1.4914898564261332 0.9046843276339587 0.08644562541442473 0.18151972390280727 0.6288478709513111 0.05101266784539767 0.11738391893266295 1.481054527463938e-07 6.829428951917166 0.5944248392599697 RDPNNYRPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RDPNNYRPR 9 2 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 8491290.0 372590.0 4150600.0 3968100.0 False True 510346.59186615254 3967212.7678012615 3030916.505584788 1.0 7.773565712067562 5.938937486584998 18.96111783237686 -9.156822631186085 11.183914976444976 1.0000158647865312 6.856251599326354 0.9314397019586432 0.7489838367462904 0.0 0.0 0.725200492354956 0.24173349384959927 6.969110792122584e-10 9.156822631186085 5.856235734539823 RDSHLTLLNQLLQGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RDSHLTLLNQLLQGLR 16 1 E9PKV2;Q9NRX2 E9PKV2 MRPL17 39S ribosomal protein L17, mitochondrial 0 8948200.0 4990100.0 1793700.0 2164400.0 False True 4831692.00694264 2509933.7640219294 1597478.7093918163 1.0 0.5194730459672129 0.33062511167856007 22.204097063263188 -13.999999689022166 0.12905497763819723 3.2833741277942594 0.06295498254544178 0.9996499158841201 0.0052723720676179555 11.938261172872329 0.11162118673120328 6.92066835681479 0.23796652383274464 1.0000007160531805e-14 13.999999689022166 -3.2204191452488176 RDSHLTLLNQLLQGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RDSHLTLLNQLLQGLR 16 1 E9PKV2;Q9NRX2 E9PKV2 MRPL17 39S ribosomal protein L17, mitochondrial 0 45795100.0 8158900.0 9400900.0 28235300.0 False True 12377647.795487385 7723235.945433044 22654580.579028394 1.0 0.6239663684927894 1.8302815650714952 23.561233840136026 -6.822950243077264 1.3589999898612621 0.7978977819820563 1.8583328225793014 0.8910395212612622 0.16635966855483855 0.18968116683879 0.6875272086441795 0.09617317009064105 0.221515381033474 1.5033141902521414e-07 6.822950243077264 1.0604350405972451 RDSHLTLLNQLLQGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RDSHLTLLNQLLQGLR 16 1 E9PKV2;Q9NRX2 E9PKV2 MRPL17 39S ribosomal protein L17, mitochondrial 0 14208400.0 4990100.0 7311100.0 1907200.0 False True 4149489.2489126767 7271713.653160278 2305986.702103537 1.0 1.752435834136874 0.5557278411331691 21.984502338697464 -6.7367462678929355 1.6985678248922877 1.4493806963347167 0.5555111243709152 0.5902320225060284 0.31617611428898357 0.3237528861445695 1.8327418801269406 0.14733348553373488 0.3628482348917965 1.8333852461014768e-07 6.7367462678929355 -0.8938695719638015 RDSHLTLLNQLLQGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RDSHLTLLNQLLQGLR 16 1 E9PKV2;Q9NRX2 E9PKV2 MRPL17 39S ribosomal protein L17, mitochondrial 0 25334600.0 8158900.0 12626700.0 4549000.0 False True 10561856.885962972 11924013.045238651 3721128.6766816243 1.0 1.1289693823712028 0.3523176574781199 23.332360162228476 -6.8642441287046925 1.1641876770177062 1.0709239763668394 0.3115578134699367 0.9585889123964421 0.06915288923279175 0.14248883619044914 0.36459789130209963 0.046244721363692454 0.1085124771392463 1.3669602041870852e-07 6.8642441287046925 -0.7593661628969027 down RDVK(ub)PDEDMSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RDVKPDEDMSGK 12 2 Q5T5P2-3;Q5T5P2;Q5T5P2-4;Q5T5P2-8;Q5T5P2-6;Q5T5P2-9;Q5T5P2-2;Q5T5P2-7;Q5T5P2-10;Q5T5P0;Q5T5P1 Q5T5P2-3 KIAA1217 Sickle tail protein homolog 1 2363560.0 198280.0 185680.0 1979600.0 True False 256677.3686831235 175346.74477416198 1619333.1124112848 1.0 0.6831406511363812 6.308826994445326 17.969596573123933 -6.893563508421612 1.0010887531644814 0.7230378455205247 6.827821150548554 0.9830820279550435 0.3356477172381354 0.11629852422210755 0.2053513369849152 0.25420286992513347 0.6424108256340297 1.2777223500354332e-07 6.893563508421612 6.10478330502803 up REDAVSK(ub)EVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 REDAVSKEVTR 11 2 Q9UNL2-2;C9JA28;Q9UNL2;C9J365 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 50683700.0 2324900.0 2539800.0 45819000.0 True False 3047966.41436363 2160871.740062861 41078089.40688304 1.0 0.70895523319407 13.477211957881606 21.539415575141632 -6.901687187496843 0.9505685595402799 0.4934381786224935 14.864202838467614 0.9873863824512797 0.6684263771740349 0.11017307610191633 0.17051046606847198 0.52568761106622 1.3796543467458782 1.2540441093596903e-07 6.901687187496843 14.37076465984512 up REDAVSK(ub)EVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 REDAVSKEVTR 11 2 Q9UNL2-2;C9JA28;Q9UNL2;C9J365 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 87695500.0 2531400.0 3831100.0 81333000.0 True False 2451042.0926183024 5360878.20892257 60029447.36230115 1.0 2.187183249552382 24.491397982551682 21.224963829657135 -6.917910597842238 0.8400882900603679 0.46984327369833495 27.920679227119045 0.9935803503240187 0.8657263428297297 0.09941667317947081 0.11210332355320878 0.7377741598969333 2.1676741249438005 1.208062496516458e-07 6.917910597842238 27.45083595342071 up REDAVSK(ub)EVTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 REDAVSKEVTR 11 2 Q9UNL2-2;C9JA28;Q9UNL2;C9J365 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 162704400.0 1749400.0 59505000.0 101450000.0 True False 2653967.6982712923 48885867.83531301 81398363.03288545 1.0 18.419918172762866 30.67044225365127 21.339719380941318 -8.075699031732796 0.42089411647024244 4.829602735040115e-20 33.93218256696386 0.9954506096123712 0.8211285059473753 0.1113716900423222 0.11489761183248728 1.8598705992188336 2.976735695741521 8.400419381499917e-09 8.075699031732796 33.93218256696386 REDAVSK(ub)EVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 REDAVSKEVTR 11 2 Q9UNL2-2;C9JA28;Q9UNL2;C9J365 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 74121200.0 2324900.0 2632300.0 69164000.0 True False 3184478.3580601183 2515996.2821479477 52828887.67729291 1.0 0.7900811370816198 16.58949496189215 21.602625636664524 -6.903888773275279 0.9363529954092126 0.41139816812483265 18.385385879285813 0.9884044177576133 0.7967377218620534 0.10859752779440639 0.16171224100321452 0.6332074493726941 1.682091727095469 1.2477030212978234e-07 6.903888773275279 17.97398771116098 up REDAVSK(ub)EVTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 REDAVSKEVTR 11 2 Q9UNL2-2;C9JA28;Q9UNL2;C9J365 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 66231000.0 2531400.0 5782600.0 57917000.0 True False 2104971.2600343763 5751447.986043773 70027176.92204843 1.0 2.7323166331258344 33.267521629204964 21.00536910509141 -6.918575484176703 0.8352169574513312 0.291039230240301 38.033901564252275 0.993776075216501 1.1691480172678657 0.09901751377650174 0.11000885208014365 0.9998127973187543 2.9553488228675597 1.2062144193679516e-07 6.918575484176703 37.742862334011974 up REDAVSK(ub)EVTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 REDAVSKEVTR 11 2 Q9UNL2-2;C9JA28;Q9UNL2;C9J365 Q9UNL2-2 SSR3 Translocon-associated protein subunit gamma 1 106505400.0 1749400.0 25659000.0 79097000.0 True False 2264632.785829418 24231054.09392623 64702157.603756025 1.0 10.699771833008965 28.57070603614836 21.110845703033768 -6.9616176763996425 0.4120018123548577 0.1386508377323244 39.797202481086366 0.9998255697190639 0.15081678512256771 0.07912824404406647 0.0190329250972692 0.23026395545661935 1.4911370260066021 1.0924015900322272e-07 6.9616176763996425 39.658551643354045 REDIQQFFEEFQSK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 REDIQQFFEEFQSKK 15 2 Q8N806;H0YJY4;H0YJM2 Q8N806 UBR7 Putative E3 ubiquitin-protein ligase UBR7 1 9456600.0 3034700.0 2123800.0 4298100.0 True False 2938365.109610797 2971844.4154706914 3172298.6697638887 1.0 1.0113938549536918 1.0796135100392876 21.486582239928406 -6.93587921372083 0.6968434796395971 0.9991530983068199 1.0959753385994806 0.9975727973113224 0.0017318960661837227 0.08969784291721396 0.06355321946500068 0.0016372446008937514 0.005985824941727736 1.1590996809286884e-07 6.93587921372083 0.09682224029266073 REDIQQFFEEFQSK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 REDIQQFFEEFQSKK 15 2 Q8N806;H0YJY4;H0YJM2 Q8N806 UBR7 Putative E3 ubiquitin-protein ligase UBR7 1 10391200.0 3034700.0 3377700.0 3978800.0 True False 2523487.510004871 3359503.659679046 4810748.684107361 1.0 1.331293951866067 1.9063889419044817 21.266987515362683 -6.962716839052947 0.39528406909160985 0.9666941087504468 2.2918286125399985 0.999858071838112 0.004461158519115403 0.0787445122561987 0.017647098451304105 0.007407685631789136 0.04827107279892473 1.0896403096294919e-07 6.962716839052947 1.3251345037895517 REDLVVAPAGITLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 REDLVVAPAGITLK 14 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 6771100.0 1298000.0 3108100.0 2365000.0 False True 1701690.5698498788 2644383.59527891 2120292.486681908 1.0 1.5539744076458004 1.2459917944241519 20.698537294992096 -10.156257741839104 4.579130644175909 0.9999599981593835 1.3999831010367778 0.6922032575412251 0.12573337565066392 7.029336879593258e-05 1.2952110283196265e-05 0.12175744193273694 0.04058027244992613 6.97818145272945e-11 10.156257741839104 0.4000231028773943 REDLVVAPAGITLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 REDLVVAPAGITLK 14 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 8439000.0 4301500.0 1332300.0 2805200.0 False True 4164951.2370220567 1864294.337852717 2070433.9658038819 1.0 0.4476149255436875 0.4971088130396081 21.989868174034257 -10.291156768880448 8.719126779370232 1.0000003482106514 0.4723618703856852 0.9934440520003702 0.02020579495862037 1.3676826445432574e-07 1.1117340911325283e-08 0.019564189814985245 0.0065213922809682166 5.114971651940504e-11 10.291156768880448 -0.5276384778249662 REDLVVAPAGITLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 REDLVVAPAGITLK 14 1 P12268;H0Y4R1;E7ETK5 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 11389200.0 1298000.0 6657200.0 3434000.0 False True 1777905.67713107 6363062.891583525 2622959.9254500004 1.0 3.578965393626126 1.4753088193534305 20.761747356514988 -6.595695686384526 2.206762064090291 2.7392272455671747 1.4818206801274971 0.008366414673439126 1.1159346752332167 0.6531241117155442 6.004307334462904 0.4207424419660289 1.2425368680034223 2.53690563790554e-07 6.595695686384526 -1.2574065654396775 REDYYDIQLSIK(ub)GK ddPTM_RPMI8226_Bortezomib_8h_R1 1 REDYYDIQLSIKGK 14 2 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 44704000.0 17238000.0 16611000.0 10855000.0 True False 26151306.266606 13646637.267664619 8709504.492084492 1.0 0.5218338666734494 0.3330428087718939 24.640379675589564 -13.999999709491462 0.12835148517790632 3.2721151157280195 0.06303417974509022 0.9996531424402129 0.005227727637462314 11.939545483125436 0.11124441602096424 6.85431719852841 0.23998926189022943 1.000000668920853e-14 13.999999709491462 -3.209080935982929 REEDAEK(ub)AVIDLNNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 REEDAEKAVIDLNNR 15 2 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 1 5628600.0 1948800.0 1743200.0 1936600.0 True False 2554895.6722060437 1483121.3549403793 1736219.2091789364 1.0 0.5805017289256931 0.6795655995142005 21.28483295001193 -9.804458190961329 6.184104427879073 1.000000014955702 0.6300336642196604 0.9489706293547738 0.040442655815538964 8.33201205564146e-09 1.6512266339682954e-09 0.03915843457079723 0.013052811037344575 1.5687069080515157e-10 9.804458190961329 -0.36996635073604156 REEDAEK(ub)AVIDLNNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 REEDAEKAVIDLNNR 15 2 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 1 7725000.0 2051500.0 1841400.0 3832100.0 True False 1986376.255434326 2576680.622774145 2828358.0494642337 1.0 1.297176512115902 1.4238783018707635 20.921707490496527 -12.62934179199785 0.13142507930542768 2.532219574875027e-21 1.6114093412361552 0.9996729252336686 0.003212856621799966 7.227831480705529 0.09957206271591457 2.063103627666892 0.15238815573859482 2.3477843751597325e-13 12.62934179199785 1.6114093412361552 REEDAEK(ub)AVIDLNNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 REEDAEKAVIDLNNR 15 2 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 1 39470700.0 4623300.0 9711400.0 25136000.0 True False 7013884.10850444 7978324.794485479 20167858.582499817 1.0 1.1375045083524606 2.87541942103748 22.741782162237794 -6.92265957987358 0.8047621292635824 0.9652046430337665 3.173560277089589 0.9948882753243853 0.061023480053362084 0.096631935851005 0.09769179390318436 0.05333255531474228 0.1640529151164268 1.1949243745302707e-07 6.92265957987358 2.2083556340558226 up REEDAEK(ub)AVIDLNNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 REEDAEKAVIDLNNR 15 2 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 1 6148400.0 1948800.0 2257500.0 1942100.0 True False 2669324.024339777 2157756.1854458023 1483415.9788050216 1.0 0.8083530383612741 0.5557272048199264 21.34804301153482 -6.967315923162531 0.3157990368067573 1.0363476901778983 0.31963442284422006 0.9999532263078458 0.0012443128902492008 0.07718373604897219 0.012133859404449502 0.00389668000546009 0.022305888205614435 1.0781621386677496e-07 6.967315923162531 -0.7167132673336782 REEDAEK(ub)AVIDLNNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 REEDAEKAVIDLNNR 15 2 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 1 59144200.0 4623300.0 7098900.0 47422000.0 True False 5984952.988867696 6703839.9745653765 38791682.59081028 1.0 1.120115728065842 6.481535053485749 22.512908484330243 -6.911731424856653 0.8838676031960913 0.8429520544396013 7.200680299320775 0.9915585886526654 0.23485447400347745 0.10328400259425523 0.13264140821297826 0.19394000420028065 0.542002996089911 1.2253737571090704e-07 6.911731424856653 6.357728244881173 up REESLEK(ub)EPEYVPWTATSGPGGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 REESLEKEPEYVPWTATSGPGGIR 24 2 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 11399100.0 3622300.0 4237600.0 3539200.0 True False 4748870.378403098 3605366.598035428 3172997.5344036464 1.0 0.7592050973705043 0.6681583790607967 22.179152947338242 -13.999999999999998 0.13488850983410108 2.1461261679270542 0.5482300815978315 0.9996240738738768 0.002714355188385221 11.932176103450194 0.11466752258651294 3.6114718219134843 0.10688806747962763 1.0000000000000041e-14 13.999999999999998 -1.5978960863292229 REESLEK(ub)EPEYVPWTATSGPGGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 REESLEKEPEYVPWTATSGPGGIR 24 2 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 11037000.0 3622300.0 3386700.0 4028000.0 True False 4961562.198976796 3237064.395680753 3076669.3592640087 1.0 0.6524284622186779 0.6201009351245256 22.242363008861133 -13.999999999999998 0.3360130537062133 4.923670399826372 0.614771063860617 0.9997271820936722 0.0028405169108477487 19.34397342221628 0.18570114533418566 53.803453029845464 0.010132452056945702 1.0000000000000041e-14 13.999999999999998 -4.308899335965755 REFTK(ub)EDYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 REFTKEDYK 9 2 Q92575 Q92575 UBXN4 UBX domain-containing protein 4 1 13254100.0 4288500.0 4840000.0 4125600.0 True False 4152363.9149062196 6772637.240266563 3044981.594652969 1.0 1.6310317156822518 0.7333127965306816 21.985501456956246 -6.717807978351912 1.7674213423342673 1.384809556085139 0.7349011298739331 0.5020816420014531 0.2656138838603628 0.3595799643599682 2.1940319645199082 0.1193887143785314 0.3004610599715029 1.9151024931139708e-07 6.717807978351912 -0.6499084262112059 REFTK(ub)EDYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 REFTKEDYK 9 2 Q92575 Q92575 UBXN4 UBX domain-containing protein 4 1 12335700.0 4288500.0 5109600.0 2937600.0 True False 3566077.762762675 5082073.570623807 3551838.5780722285 1.0 1.4251157458458434 0.9960070459373788 21.765906732390523 -10.280567125128357 14.965928855103877 0.9998166269686126 1.210561395891611 0.2430214126336564 0.17518292515180972 0.0 0.0 0.16962012345814065 0.056540041152713535 5.2412258566906424e-11 10.280567125128357 0.21074476892299843 REPFAVVK(ub)TASEMER ddPTM_RPMI8226_Bortezomib_1h_R1 1 REPFAVVKTASEMER 15 2 A0A075B6T1;Q9C0C7-4;Q9C0C7-2;Q9C0C7-3;Q9C0C7;Q9C0C7-5;Q9C0C7-6 A0A075B6T1 AMBRA1 Activating molecule in BECN1-regulated autophagy protein 1 1 23407400.0 5981300.0 7285100.0 10141000.0 True False 7841542.2229915885 6198191.477097381 9091706.599340905 1.0 0.7904301603993327 1.15942838038719 22.902705991349933 -6.752653170852043 1.6402174193068233 0.8771651402663629 1.1603046313106389 0.6602542022829191 0.0880761099800685 0.29542833584665623 1.5645686966719912 0.04240668437663367 0.10265907337912152 1.767448748204172e-07 6.752653170852043 0.28313949104427594 REPFAVVK(ub)TASEMER ddPTM_RPMI8226_Bortezomib_2h_R1 1 REPFAVVKTASEMER 15 2 A0A075B6T1;Q9C0C7-4;Q9C0C7-2;Q9C0C7-3;Q9C0C7;Q9C0C7-5;Q9C0C7-6 A0A075B6T1 AMBRA1 Activating molecule in BECN1-regulated autophagy protein 1 1 43369700.0 5336200.0 8570500.0 29463000.0 True False 5166805.2518882 11992745.344567059 21745756.428946164 1.0 2.321114259180628 4.208743192130034 22.30084107580224 -6.96605259131868 0.3395020411384631 0.7940749671174724 5.798466326215523 0.9999332280046049 0.010759721980923741 0.07760556365053449 0.01361041473829392 0.026687244839773784 0.1634421073750185 1.0813030019157476e-07 6.96605259131868 5.004391359098051 REPFAVVK(ub)TASEMER ddPTM_RPMI8226_Bortezomib_8h_R1 2 REPFAVVKTASEMER 15 2 A0A075B6T1;Q9C0C7-4;Q9C0C7-2;Q9C0C7-3;Q9C0C7;Q9C0C7-5;Q9C0C7-6 A0A075B6T1 AMBRA1 Activating molecule in BECN1-regulated autophagy protein 1 1 186751600.0 22857500.0 78409300.0 85484800.0 True False 34676498.60708591 64416547.80034289 68588691.8106812 1.0 1.8576427952036596 1.9779589798799797 25.047454896761636 -11.006803631529433 0.3615048161176745 3.3869935884943284e-18 1.9954861788744966 0.9994032755230748 0.01063677475770152 2.83591845085786 0.17963888376253445 2.3925547168739167 0.034453488874289215 9.844561320167799e-12 11.006803631529433 1.9954861788744966 REPFAVVK(ub)TASEMER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 REPFAVVKTASEMER 15 2 A0A075B6T1;Q9C0C7-4;Q9C0C7-2;Q9C0C7-3;Q9C0C7;Q9C0C7-5;Q9C0C7-6 A0A075B6T1 AMBRA1 Activating molecule in BECN1-regulated autophagy protein 1 1 24300400.0 5981300.0 5829100.0 12490000.0 True False 8192748.248554754 5571551.087744019 9540119.239624497 1.0 0.680058866538084 1.1644589764255757 22.965916052872824 -6.7286030465484705 1.728416084154741 0.8071580272564896 1.164092038583417 0.5527023085846475 0.13451140601055456 0.33888037002510923 1.9827140195549098 0.06168949144377552 0.15331558052905467 1.8680863773733686e-07 6.7286030465484705 0.3569340113269275 REPFAVVK(ub)TASEMER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 REPFAVVKTASEMER 15 2 A0A075B6T1;Q9C0C7-4;Q9C0C7-2;Q9C0C7-3;Q9C0C7;Q9C0C7-5;Q9C0C7-6 A0A075B6T1 AMBRA1 Activating molecule in BECN1-regulated autophagy protein 1 1 27966000.0 5336200.0 9041800.0 13588000.0 True False 4437286.733742373 8993090.028743224 16429187.976186505 1.0 2.026709241112873 3.702530163591717 22.081246351236516 -6.963815281283139 0.3778332746805123 0.8820458849816009 4.90625165300478 0.9998866030743438 0.011861280769993442 0.07836531684484846 0.016291759998126296 0.021860335881114138 0.14175434117864158 1.0868878119245682e-07 6.963815281283139 4.0242057680231795 REPFAVVK(ub)TASEMER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 REPFAVVKTASEMER 15 2 A0A075B6T1;Q9C0C7-4;Q9C0C7-2;Q9C0C7-3;Q9C0C7;Q9C0C7-5;Q9C0C7-6 A0A075B6T1 AMBRA1 Activating molecule in BECN1-regulated autophagy protein 1 1 157957000.0 17424000.0 61560000.0 78973000.0 True False 22555711.47838788 58134131.884410925 64600724.331408545 1.0 2.5773574883733144 2.8640517233653555 24.42698945814524 -10.261942686388087 0.37678267852596026 2.0247456992690237e-14 2.9039803529748762 0.999059330334082 0.025135832113536382 1.66108742716958 0.17432242103892098 1.7802896438263327 0.07795594756468273 5.4708815706341815e-11 10.261942686388087 2.903980352974856 REPLGVCVGIGAWNYPFQIASWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 REPLGVCVGIGAWNYPFQIASWK 23 1 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 311046000.0 110020000.0 79796000.0 121230000.0 False True 166908383.539389 65555780.351006426 97268837.36300343 1.0 0.3927650544619635 0.5827678352660385 27.314481179868572 -10.35911431691322 6.4635580676417 1.0000369033844194 0.4877664448640097 0.9064607009440517 0.0775683104466438 4.125300524105502e-05 4.090352795581878e-06 0.07511058208243783 0.02503506454610817 4.3740695381176086e-11 10.35911431691322 -0.5122704585204096 REPLGVCVGIGAWNYPFQIASWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 REPLGVCVGIGAWNYPFQIASWK 23 1 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 240615000.0 110020000.0 42764000.0 87831000.0 False True 142423058.8184247 40384145.80742282 71846659.22216387 1.0 0.283550614222579 0.5044594591509318 27.08560750196102 -10.217587603618824 6.462303935996121 1.0000053245299068 0.39400503668721226 0.9093665672747228 0.09018565829034782 6.918472580956711e-06 8.374375001864191e-07 0.08732265530972715 0.02910729605210567 6.059159659893275e-11 10.217587603618824 -0.6060002878426944 REPVSLEEWTK(ub)NIDSEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 REPVSLEEWTKNIDSEGR 18 2 Q8TC07-2;Q8TC07-3;Q8TC07;C9JA93 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 9666900.0 2505100.0 1941600.0 5220200.0 True False 2425576.9717224147 2716891.005310238 3852873.0173568535 1.0 1.1201009231964136 1.5884356844882594 21.209896531153444 -6.945460270097492 0.6066493903287818 0.9947925741513893 1.7379932085818204 0.9987950624774855 0.008812147144429718 0.08536169371437072 0.04391442923069803 0.008985995684949696 0.03944518158948277 1.1338085558473683e-07 6.945460270097492 0.743200634430431 REPVSLEEWTK(ub)NIDSEGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 REPVSLEEWTKNIDSEGR 18 2 Q8TC07-2;Q8TC07-3;Q8TC07;C9JA93 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 45431500.0 4110500.0 15337000.0 25984000.0 True False 6235929.017802764 12599992.521472067 20848251.010808226 1.0 2.0205477781258785 3.3432470047829583 22.57217307557559 -6.967571891128086 0.3107650775166144 0.7980594832077677 4.607826395641627 0.9999567679863794 0.006307324471144422 0.07709875991039573 0.011836452761579293 0.020855805410180086 0.11734369022903306 1.0775268700459379e-07 6.967571891128086 3.80976691243386 REPVSLEEWTK(ub)NIDSEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 REPVSLEEWTKNIDSEGR 18 2 Q8TC07-2;Q8TC07-3;Q8TC07;C9JA93 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 8393100.0 2505100.0 2084400.0 3803600.0 True False 2083101.6447468302 2073170.9234789934 4598915.174140631 1.0 0.9952327236201458 2.2077248058145336 20.99030180658772 -6.906014362569979 0.9224528076578021 0.9575648156549823 2.3517601089552556 0.9893284945082399 0.05892958818523405 0.10711290109012998 0.15350170871362978 0.04731516588927444 0.12727075688127804 1.2416112455388487e-07 6.906014362569979 1.3941952933002733 up REPVSLEEWTK(ub)NIDSEGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 REPVSLEEWTKNIDSEGR 18 2 Q8TC07-2;Q8TC07-3;Q8TC07;C9JA93 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 36310500.0 4110500.0 10083000.0 22117000.0 True False 5321123.280068497 9521872.186330657 18091932.939583942 1.0 1.7894477697964715 3.4000213840847247 22.34329939766804 -6.959654391436602 0.44027711847913725 0.9425788531445235 4.30971317255017 0.9997571669650944 0.015563416190176219 0.07982480277503966 0.02158919462549273 0.02124178102274213 0.1334391131498543 1.0973511132392304e-07 6.959654391436602 3.3671343194056464 REQQLVSK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 REQQLVSKR 9 2 D6R986;Q96DC7;Q96DC7-2 D6R986 TMCO6 Transmembrane and coiled-coil domain-containing protein 6 1 27002300.0 4882600.0 20685000.0 1434700.0 True False 4060098.235855198 20573565.79934899 1734689.1366966993 1.0 5.067258131259349 0.42725299633823105 21.95308320379536 -6.675168195658541 1.9189907343003358 3.5845590654643606 0.4455547032047971 0.30205216510503863 1.725668602682033 0.4494315067773491 3.195473404434903 0.7226880893265091 1.917966390395343 2.112670676102755e-07 6.675168195658541 -3.1390043622595636 RESSLK(ub)YQTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RESSLKYQTR 10 2 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 5747250.0 2000000.0 2916500.0 830750.0 True False 2622019.3680275506 2481369.56842796 744791.9591166999 1.0 0.9463582148497262 0.2840528060923439 21.322246911655046 -6.922987976630047 0.8022651034744579 1.0131005366528383 0.16955196222631924 0.9949711917921198 0.02308924038450765 0.09644570405012515 0.096740395467518 0.0202151638653467 0.06239646156236206 1.1940211602824285e-07 6.922987976630047 -0.843548574426519 down RESSLK(ub)YQTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RESSLKYQTR 10 2 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 4937630.0 2000000.0 2191300.0 746330.0 True False 2739454.047967753 2094481.1203399305 570062.2251488353 1.0 0.7645615088501698 0.20809337012669823 21.385456973177938 -7.067689499626531 0.5185062480544425 1.0087505784284243 2.932675702674766e-13 0.9994604600258828 0.007712425179601359 0.07459820390037024 0.03046806654234899 0.008856551504075015 0.041719159629876844 8.556782644399956e-08 7.067689499626531 -1.008750578428131 down RESSLK(ub)YQTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RESSLKYQTR 10 2 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 6355700.0 2836000.0 2878700.0 641000.0 True False 2358259.6561023504 2863191.871722789 775030.1363508634 1.0 1.214112222254174 0.3286449540640517 21.169291144277782 -6.842820157197462 1.2692082267208582 1.1138892420113513 0.2978480241937471 0.9292155555002835 0.10035910243975668 0.16551411057099738 0.5166942170179373 0.0619731158851856 0.14290259147456671 1.436083997442803e-07 6.842820157197462 -0.8160412178176042 down RFALTFGLDQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RFALTFGLDQLK 12 1 Q8N3U4-2;Q8N3U4 Q8N3U4-2 STAG2 Cohesin subunit SA-2 0 23788300.0 5298900.0 6497400.0 11992000.0 False True 8038818.7014803635 5337888.205582099 9621775.943719681 1.0 0.664014005515402 1.1969141612744436 22.93855208332423 -6.736262243083544 1.7001243085357933 0.7992360480754386 1.196995903957766 0.5882000979321882 0.1411847887108104 0.3246004708111954 1.8406713223804303 0.06573265769611407 0.16198459581704483 1.8354297082684655e-07 6.736262243083544 0.39775985588232743 RFALTFGLDQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RFALTFGLDQLK 12 1 Q8N3U4-2;Q8N3U4 Q8N3U4-2 STAG2 Cohesin subunit SA-2 0 18538200.0 5298900.0 7211600.0 6027700.0 False True 6859530.506934662 6810268.120494121 4930720.449424889 1.0 0.9928184026019361 0.718813108920525 22.70967840541668 -6.91252294804155 0.8783643386325493 1.0078218975464308 0.6814212178808257 0.9918396272424944 0.011824179462173632 0.10277357421485446 0.12988765727623558 0.009803023604823645 0.027558526642548098 1.223142486715507e-07 6.91252294804155 -0.32640067966560515 RFDAMPFTLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RFDAMPFTLR 10 1 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 11737600.0 3948600.0 3566500.0 4222500.0 False True 5176652.838296796 3034392.102108114 3785596.2050800733 1.0 0.5861687458853198 0.7312826112414362 22.30358813935585 -10.333634842240572 6.978528387082821 1.0000076358157814 0.658725678563378 0.8805888098020938 0.05924248745423775 7.038229971332087e-06 6.720933034687376e-07 0.05736257395313067 0.01912043060818039 4.6383675292831004e-11 10.333634842240572 -0.3412819572524034 RFDAMPFTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RFDAMPFTLR 10 1 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 10168200.0 3948600.0 4409500.0 1810100.0 False True 5408504.126902738 4214673.70973345 1382591.660179687 1.0 0.7792679104688133 0.2556329121212022 22.36679820087874 -6.956575496419192 0.48127477019973075 1.012419159172884 0.000602826006382048 0.9996213516910488 0.006074296920401364 0.0809478705110787 0.02582943507390252 0.007402301749172268 0.043193639337660523 1.1051583353518073e-07 6.956575496419192 -1.011816333166502 down RFDAMPFTLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RFDAMPFTLR 10 1 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 17117400.0 4870400.0 6691400.0 5555600.0 False True 6304828.809936891 6319017.707786671 4544537.8052698225 1.0 1.002250481064199 0.7208027279197945 22.588025768044517 -6.905095972757048 0.9284734417052164 1.0101224265809454 0.688000426063096 0.9889359102054459 0.013900167241759135 0.1077513056111571 0.15701417404438342 0.011111227927979694 0.029723988447720354 1.244239622548102e-07 6.905095972757048 -0.32212200051784945 RFDDAVVQSDMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RFDDAVVQSDMK 12 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 45630500.0 3257500.0 21507000.0 20866000.0 False True 4270614.045674876 18298239.4336294 18706986.480805393 1.0 4.284685817525748 4.380397357553571 22.026012090448457 -10.275784098551048 0.7270421723012241 1.4969066614241826e-17 4.362789643209184 0.9999039450388933 0.015401516493726385 1.5949616409595158 0.3707719462946929 3.2911379315272566 0.014548718111784795 5.2992682171299864e-11 10.275784098551048 4.362789643209184 RFDDAVVQSDMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RFDDAVVQSDMK 12 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 36468400.0 12408000.0 3190400.0 20870000.0 False True 12014114.831795823 4464343.35771621 15403520.913420433 1.0 0.37159153380997756 1.2821186686724864 23.518227022640083 -6.721032708986697 1.7556686178288814 0.6181007071916882 1.2807739805262266 0.5173278436301603 0.2644042004076844 0.35332908006447605 2.1290067157865136 0.11955462127930104 0.2997550252028949 1.900935105176258e-07 6.721032708986697 0.6626732733345384 RFDDAVVQSDMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RFDDAVVQSDMK 12 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 35971500.0 3257500.0 15699000.0 17015000.0 False True 4461885.780627482 15005366.270349365 12996407.434924794 1.0 3.363009948730498 2.9127611225173697 22.08922215197135 -10.100215379867617 4.921561518067778 0.9999202669019679 3.1378855356355695 0.9678052169031168 0.18381331362510386 0.00016081860742435196 2.9401551892470087e-05 0.17798296114223883 0.05932549186769382 7.939344008127009e-11 10.100215379867617 2.1379652687336015 RFDDAVVQSDMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RFDDAVVQSDMK 12 1 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 12408000.0 12408000.0 0.0 0.0 False True 10317801.767601557 0.0 0.0 1.0 0.0 0.0 23.29863229807436 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 RFDDAVVQSDMK(ub)HWPFMVVNDAGRPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RFDDAVVQSDMKHWPFMVVNDAGRPK 26 3 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 81186000.0 19719000.0 26573000.0 34894000.0 True False 29915164.652001582 21830840.534203384 27997185.605416484 1.0 0.729758327863414 0.9358860608358119 24.834373667768418 -10.525889090452877 5.356234988943539 1.0004827576650719 0.8328221943496124 0.4672484352948638 0.08415129460317515 0.0004865061708924811 4.306331759236971e-05 0.0817115455902284 0.027159713546657333 2.97927717612825e-11 10.525889090452877 -0.16766056331545953 RFDDAVVQSDMK(ub)HWPFMVVNDAGRPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RFDDAVVQSDMKHWPFMVVNDAGRPK 26 3 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 75163000.0 19719000.0 26438000.0 29006000.0 True False 25526634.219601147 24966702.059130196 23727205.626693174 1.0 0.978064786933759 0.9295078004633198 24.605499989860867 -6.958012443345438 0.46259670208281245 1.001379238892436 0.9042273830843552 0.9996891870346876 0.0005192466822398791 0.08041894147326233 0.02381380732757914 0.0006624181735237602 0.004010207870691834 1.1015077488415862e-07 6.958012443345438 -0.09715185580808083 RFDSEK(ub)AGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RFDSEKAGDR 10 2 P17980;R4GNH3;E9PM69;E9PKD5 P17980 PSMC3 26S protease regulatory subunit 6A 1 32254900.0 7815900.0 13673000.0 10766000.0 True False 10246720.589283265 11633041.696936565 9652037.594764259 1.0 1.1352941261132083 0.9419635785579078 23.288658920616026 -6.718553525472442 1.7644471870339014 1.0824348044146626 0.9422865886832109 0.5058099523924525 0.05694211405999291 0.35808728787509153 2.1779258459190487 0.025631979344954186 0.06445737237424015 1.9118176843758628e-07 6.718553525472442 -0.14014821573145164 RFDSEK(ub)AGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RFDSEKAGDR 10 2 P17980;R4GNH3;E9PM69;E9PKD5 P17980 PSMC3 26S protease regulatory subunit 6A 1 32268900.0 7815900.0 10108000.0 14345000.0 True False 10705649.446755579 9661395.13731392 10957006.444548706 1.0 0.9024576402734606 1.0234789116758631 23.351868982138917 -6.692221484888643 1.8586862839401803 0.9389735260005984 1.0230700316317134 0.38073676651341426 0.04123534484213748 0.4119290711475398 2.7608738887587654 0.01773719857282105 0.04605718361142445 2.0313207978999437e-07 6.692221484888643 0.08409650563111504 RFDSEK(ub)AGDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RFDSEKAGDR 10 2 P17980;R4GNH3;E9PM69;E9PKD5 P17980 PSMC3 26S protease regulatory subunit 6A 1 27519500.0 8180100.0 12095000.0 7244400.0 True False 6802115.589874075 12029841.834330475 8759170.54567894 1.0 1.768544164735839 1.2877126873171962 22.697552091618267 -10.24940685185205 4.527621140276904 0.9997889730444679 1.5281284260306613 0.6166438892262478 0.1962986286714795 0.0004183101470864392 6.934764292156814e-05 0.1901403333321672 0.06335510997534965 5.631098811157359e-11 10.24940685185205 0.5283394529861934 RFDSEK(ub)AGDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RFDSEKAGDR 10 2 P17980;R4GNH3;E9PM69;E9PKD5 P17980 PSMC3 26S protease regulatory subunit 6A 1 9043800.0 2671400.0 4894200.0 1478200.0 True False 3458179.9611665197 4621833.467652431 1209182.767612832 1.0 1.3364930453455595 0.349658716779143 21.721581517057093 -6.814664979347574 1.3946570674641554 1.1824017256542696 0.33045826288513136 0.871710283859862 0.14671180490962846 0.2004995003834089 0.7676622165682709 0.08269188222764128 0.19092782976816175 1.532269018987773e-07 6.814664979347574 -0.8519434627691382 down RFEHSAK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RFEHSAKLR 9 2 Q9UPT9;Q9UPT9-2 Q9UPT9 USP22 Ubiquitin carboxyl-terminal hydrolase 22 1 11434700.0 3265200.0 6068600.0 2100900.0 True False 4280708.820241775 5163188.535217526 1883519.021255824 1.0 1.206152707888669 0.44000166802969853 22.02941827407643 -6.8350673187486315 1.3049859408591389 1.1098353297626204 0.41714884342555586 0.9156476073242589 0.09401621176403593 0.17464709997763497 0.5798416791095239 0.0565311769270928 0.13012315714390452 1.4619505441094987e-07 6.8350673187486315 -0.6926864863370645 down RFEHSAK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RFEHSAKLR 9 2 Q9UPT9;Q9UPT9-2 Q9UPT9 USP22 Ubiquitin carboxyl-terminal hydrolase 22 1 16639700.0 5872500.0 6502900.0 4264300.0 True False 5686080.701943986 9099541.882175503 3147351.9037421593 1.0 1.6003188064257523 0.5535186833817055 22.439003144503552 -6.751169288236856 1.6454226073929912 1.352496891848977 0.5512405074038681 0.654016505136374 0.25227457635461464 0.29801497760655055 1.5878133067396087 0.12109489649522852 0.2936365951418643 1.7734980355897982e-07 6.751169288236856 -0.8012563844451089 RFEHSAK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RFEHSAKLR 9 2 Q9UPT9;Q9UPT9-2 Q9UPT9 USP22 Ubiquitin carboxyl-terminal hydrolase 22 1 11126600.0 3265200.0 4819500.0 3041900.0 True False 4472432.67871215 4606558.554044759 2323465.8698970163 1.0 1.0299894676941745 0.5195082937650981 22.092628335599322 -6.892953128944819 1.0047292229073808 1.025518562811102 0.4729717450603655 0.9827228118169783 0.03074382020603159 0.11678055635008369 0.20810365000826309 0.023219454836922712 0.058538249829322195 1.2795193883152123e-07 6.892953128944819 -0.5525468177507367 RFEHSAK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RFEHSAKLR 9 2 Q9UPT9;Q9UPT9-2 Q9UPT9 USP22 Ubiquitin carboxyl-terminal hydrolase 22 1 15265800.0 5872500.0 7789600.0 1603700.0 True False 4883243.945860748 7747635.878685451 1939026.255328985 1.0 1.5865756379532683 0.3970774912796623 22.219408419937828 -6.772607592350222 1.564338805893628 1.3353252093063694 0.3896959881293863 0.7404715185507313 0.24739694191979353 0.2622381149704081 1.2668158489449262 0.12462574229747325 0.29597327439657745 1.688077602419551e-07 6.772607592350222 -0.9456292211769832 down RFELYFQGPSSNK(ub)PR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RFELYFQGPSSNKPR 15 2 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 40720100.0 13930000.0 17963000.0 8827100.0 True False 18262364.89831189 15282990.419225583 7913756.367522148 1.0 0.8368571378528468 0.4333368877244189 24.122370264481575 -6.955690405958198 0.4924291260582671 1.0086394139130728 0.24437289785609695 0.9995754727178172 0.004907393997028737 0.08127807321501294 0.027104883107337614 0.005840496320128825 0.03328146975567626 1.1074129403884987e-07 6.955690405958198 -0.7642665160569758 down RFELYFQGPSSNK(ub)PR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RFELYFQGPSSNKPR 15 2 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 76187900.0 19299000.0 31585000.0 25303900.0 True False 18686363.80873851 44197055.213599116 18676049.48927165 1.0 2.365203614034891 0.9994480296128003 24.155482525671786 -6.646178068046972 2.0215449772883924 1.888479938774415 1.0050812324168252 0.1790696924100167 0.5832196265625 0.5178600480662933 4.051748355128265 0.23429879137353227 0.6461553575109076 2.2585095534229734e-07 6.646178068046972 -0.8833987063575897 RFELYFQGPSSNK(ub)PR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RFELYFQGPSSNKPR 15 2 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 240184000.0 73089000.0 43165000.0 123930000.0 True False 110881356.5216362 35461868.50031566 99435181.1795514 1.0 0.3198181336588898 0.8967709658219114 26.724441571714316 -10.393820234758426 8.406855807103785 1.0000031397403546 0.6082945497404831 0.38064329797004526 0.23554000740883768 1.3861056437171646e-05 9.996958774156377e-07 0.22806245560159824 0.07602021050499999 4.038125063760322e-11 10.393820234758426 -0.39170858999987146 RFELYFQGPSSNK(ub)PR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RFELYFQGPSSNKPR 15 2 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 49591000.0 13930000.0 16883000.0 18778000.0 True False 19080297.4440954 16137053.235384962 14343023.145049565 1.0 0.8457443225225372 0.7517190540175863 24.185580326004466 RFELYFQGPSSNK(ub)PR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RFELYFQGPSSNKPR 15 2 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 84546000.0 19299000.0 50501000.0 14746000.0 True False 16047973.590662664 50228941.089336395 17829320.422199458 1.0 3.1299242116500956 1.1110013561197067 23.935887801106063 -6.633602907214013 2.0675554244873284 2.3995320427765177 1.1192536142400764 0.13057296275781216 0.9127956408848084 0.5496637794736933 4.482470515338887 0.3605206930601058 1.010902875260208 2.3248615385761478e-07 6.633602907214013 -1.2802784285364412 RFELYFQGPSSNK(ub)PR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RFELYFQGPSSNKPR 15 2 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 1 222487000.0 73089000.0 42508000.0 106890000.0 True False 94615151.29958054 40142392.432464875 87437116.78401822 1.0 0.42427023453528884 0.9241344074710142 26.495567893806765 -10.300655127031318 8.245785694937762 1.0000005575708184 0.6742023210031548 0.361597418863846 0.20406869406514264 2.0917567677347897e-06 1.7746306122389975e-07 0.1975890019718309 0.06586288779971615 5.004317697805901e-11 10.300655127031318 -0.3257982365676636 RFELYFQGPSSNKPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RFELYFQGPSSNKPR 15 2 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 280628000.0 65666000.0 96200000.0 118762000.0 False True 86088761.91044863 81847334.98466294 106473647.48554623 1.0 0.9507319325814243 1.2367891594991505 26.359321583665757 -6.862517227050034 1.173033763037592 0.9730715487835627 1.2513169385244842 0.9566226969257349 0.02600625526790415 0.14422643835138932 0.3756985453371046 0.017273833533380058 0.04044122968481674 1.372406521023387e-07 6.862517227050034 0.2782453897409215 RFELYFQGPSSNKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RFELYFQGPSSNKPR 15 2 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 166630000.0 40990000.0 37176000.0 88464000.0 False True 39688794.88679161 52020570.67027883 65292624.53688671 1.0 1.3107117718908423 1.6451148169937513 25.242228421126132 -6.970188491933292 0.2536421318611572 0.8985195830055439 2.0671469369231494 0.9999838158331326 0.0010597360731550336 0.07624156261182086 0.008810964304111426 0.007278109619651574 0.0318621248712193 1.0710543467124987e-07 6.970188491933292 1.1686273539176055 RFELYFQGPSSNKPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RFELYFQGPSSNKPR 15 2 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 524155000.0 135370000.0 156704000.0 232081000.0 False True 205366186.87263307 128738946.86605954 186210088.62528434 1.0 0.6268750899382609 0.9067222382658873 27.613623423486846 -9.81581418882951 6.725504990921108 1.000000002532115 0.7667986641020579 0.48075933705607254 0.11424711989599895 4.282179602523767e-09 7.352708833246934e-10 0.11061929982567148 0.036873099392438526 1.528219761145737e-10 9.81581418882951 -0.23320133843005708 RFELYFQGPSSNKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RFELYFQGPSSNKPR 15 2 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 184040000.0 65666000.0 57036000.0 61338000.0 False True 89944494.75692528 54515960.9271702 46851227.695763655 1.0 0.6061067002988834 0.5208904427378124 26.42253164518865 -13.999999999999998 0.21514557399142786 3.3275921692644594 0.47313230636127795 0.9994935160460763 0.004696582727335646 12.87208062816604 0.14697868284979762 12.6971385235029 0.048717870706391164 1.0000000000000041e-14 13.999999999999998 -2.8544598629031817 RFELYFQGPSSNKPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RFELYFQGPSSNKPR 15 2 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 90474200.0 40990000.0 32139000.0 17345200.0 False True 34085001.16489261 31965860.82790795 20972001.124856513 1.0 0.937827775720678 0.6152853280949152 25.02263369656041 -6.938986147093216 0.6689328349297385 1.0036916822823212 0.5308412290526026 0.9980280078935037 0.007488073087682699 0.08823236366926897 0.05673974829220703 0.0072342305875797526 0.027886912904642548 1.1508370971814413e-07 6.938986147093216 -0.47285045322971864 RFELYFQGPSSNKPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RFELYFQGPSSNKPR 15 2 P33993;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 504256000.0 135370000.0 239636000.0 129250000.0 False True 175239133.54163018 226300045.9430262 105727826.21699277 1.0 1.2913784801912747 0.6033345639196273 27.384749745579295 -6.791629127427582 1.4896557727227477 1.1625053918503543 0.5956672972716106 0.8066199226305506 0.12400372761796075 0.23292353865003487 1.0210342906638086 0.06551406626869069 0.15321518076214946 1.6157377524005474e-07 6.791629127427582 -0.5668380945787437 RFFPYYVYNIIGGLDEEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RFFPYYVYNIIGGLDEEGK 19 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 65236000.0 18501000.0 16253000.0 30482000.0 False True 28067369.6042741 13352525.164731396 24457219.33926478 1.0 0.4757312620666125 0.8713755397848337 24.742390529035056 -9.785270013146176 6.177597828574295 1.000000010225836 0.6735534009253772 0.4758148365798759 0.16152110001152123 2.2624856503027684e-08 4.526855710094572e-09 0.15639213726172685 0.05213071086696048 1.6395700892146077e-10 9.785270013146176 -0.32644660930045877 RFFPYYVYNIIGGLDEEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RFFPYYVYNIIGGLDEEGK 19 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 42258000.0 18501000.0 11894000.0 11863000.0 False True 23949909.209231734 11232088.444333723 9704055.724659072 1.0 0.4689825062052511 0.4051813157153241 24.513516851127505 -13.999999999999998 0.29893769831314027 5.814318540091198 0.38930958152157413 0.9996474598182722 0.005006394384377714 16.519478684073206 0.1736088202095742 49.162097812439285 0.023163064751972103 1.0000000000000041e-14 13.999999999999998 -5.425008958569624 RFLDFIGHILT ddPTM_RPMI8226_Bortezomib_2h_R1 1 RFLDFIGHILT 11 1 P48426;P48426-2;H7BXS3 P48426 PIP4K2A Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 0 11707600.0 5085100.0 2742800.0 3879700.0 False True 4923676.283943013 3838014.343513047 2863490.181494841 1.0 0.7795017629468242 0.5815756390876454 22.231304481653776 -6.97240582687206 0.19222713137860997 1.1303014412753365 0.2253563492454607 0.9999955703552238 0.00035965025612019893 0.07552950437445087 0.006148618199927766 0.0068566647995858074 0.021444721659636536 1.0655999050485485e-07 6.97240582687206 -0.9049450920298758 RFLDFIGHILT ddPTM_RPMI8226_Bortezomib_8h_R1 1 RFLDFIGHILT 11 1 P48426;P48426-2;H7BXS3 P48426 PIP4K2A Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 0 54448000.0 16635000.0 17432000.0 20381000.0 False True 25236511.181400992 14321123.403162336 16352686.416690348 1.0 0.5674763559915854 0.6479773015828781 24.58900914310611 -10.825543077738779 7.301969059553488 1.0208789934386266 0.6077268287872318 0.969381715690245 0.03286437341836971 0.010475198262946251 0.0002502706701202099 0.02983983972421529 0.010606930911073965 1.4943658086325267e-11 10.825543077738779 -0.4131521646513948 RFLDFIGHILT ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RFLDFIGHILT 11 1 P48426;P48426-2;H7BXS3 P48426 PIP4K2A Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 0 10768300.0 5085100.0 2573300.0 3109900.0 False True 4228485.958126262 2559437.122139939 3760165.71144704 1.0 0.6052845267751779 0.8892463516925702 22.011709757088052 -9.916713634274721 6.266931667938072 1.000000041094434 0.747265439233846 0.5136670927473557 0.11592692957962458 6.653795724967789e-08 1.147634838937479e-08 0.11224578530814391 0.03741525563655575 1.211396642735498e-10 9.916713634274721 -0.25273460186058805 RFLDFIGHILT ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RFLDFIGHILT 11 1 P48426;P48426-2;H7BXS3 P48426 PIP4K2A Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 0 38865000.0 16635000.0 11954000.0 10276000.0 False True 21534335.424872708 11288749.391589481 8405873.44066396 1.0 0.5242209322397146 0.3903474741530663 24.36013546519856 -13.999999999996211 0.17787867797506882 3.45284859708383 0.2816429980655272 0.9995008500826116 0.005844827656681743 12.178021403301164 0.13367857612930917 10.319151759509635 0.10178629203481439 1.0000000000087245e-14 13.999999999996211 -3.1712055990183026 RFPGYDSESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RFPGYDSESK 10 1 P46777;A0A2R8Y6J3 P46777 RPL5 60S ribosomal protein L5 0 6530210.0 1842400.0 771910.0 3915900.0 False True 1783914.0204787725 1080137.6884574709 2890208.3155181184 1.0 0.6054875268975015 1.620150008542696 20.766614652509475 -6.80127451715122 1.450774879639544 0.7826807104078152 1.6345898305408564 0.8358432822614894 0.16920981270252808 0.2189442008098643 0.9096511639159757 0.09175134424896259 0.21320945035578742 1.5802488496343183e-07 6.80127451715122 0.8519091201330412 RFPVAPLIPYPLITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RFPVAPLIPYPLITK 15 1 P49756;P49756-2;P49756-3;H0YE46 P49756 RBM25 RNA-binding protein 25 0 18682400.0 3484400.0 5029000.0 10169000.0 False True 4568082.142977596 4278692.802888463 9116809.427935869 1.0 0.9366497074633379 1.995763023208968 22.123157162713397 -6.892689337641665 1.0063681261216735 0.9467068401710264 2.091794374785698 0.9825635170616792 0.06404675913178669 0.11698708732206353 0.20933325093496663 0.04831353166108366 0.12166944138843566 1.280296806930179e-07 6.892689337641665 1.1450875346146718 RFPVAPLIPYPLITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RFPVAPLIPYPLITK 15 1 P49756;P49756-2;P49756-3;H0YE46 P49756 RBM25 RNA-binding protein 25 0 20191800.0 8125000.0 3611200.0 8455600.0 False True 7867076.322400153 5053170.992159221 6240824.697437374 1.0 0.6423187960908912 0.7932838632399808 22.907396149294534 -10.147911131143085 5.2381247028048215 1.0000097097312475 0.7178013305819243 0.8232913454853014 0.06163123058402447 6.9886926505574924e-06 1.1369488331232713e-06 0.05967623393605736 0.019891394138089873 7.113590628182128e-11 10.147911131143085 -0.2822083791493232 RFPVAPLIPYPLITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RFPVAPLIPYPLITK 15 1 P49756;P49756-2;P49756-3;H0YE46 P49756 RBM25 RNA-binding protein 25 0 19571300.0 3484400.0 6058900.0 10028000.0 False True 4772676.842369417 5791197.763897051 7659592.9331428725 1.0 1.2134066384896878 1.6048840485374731 22.18636722423629 -6.961699073258355 0.4107869653624455 0.9808802467740826 1.8519572039268064 0.9998281159647685 0.003283958718555034 0.07909967113372543 0.018929201961878073 0.005042121355190384 0.0326771557609828 1.0921968678230958e-07 6.961699073258355 0.8710769571527238 RFPVAPLIPYPLITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RFPVAPLIPYPLITK 15 1 P49756;P49756-2;P49756-3;H0YE46 P49756 RBM25 RNA-binding protein 25 0 14625400.0 8125000.0 2975200.0 3525200.0 False True 6756297.498530197 2959172.00706904 4262303.021316791 1.0 0.43798722713332194 0.6308637270996483 22.68780142472881 -10.327624861909236 6.182292367877101 1.000032446579677 0.5344254771164875 0.885960374358266 0.07874150138190684 3.521722245190681e-05 3.830170085682201e-06 0.07624642808922831 0.025413710292291013 4.7030017255531014e-11 10.327624861909236 -0.4656069694631896 RGDQGPK(ub)TIDQIHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RGDQGPKTIDQIHK 14 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;H7C044 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 3480300.0 1291500.0 1133600.0 1055200.0 True False 1250502.0394313594 1586252.3916459044 778811.464678547 1.0 1.2684924467354093 0.6227990360037284 20.254075979721993 -6.793781159146045 1.4813160992724554 1.1493255594453735 0.6152100330181983 0.8133098751825607 0.11443356819518903 0.22975865873652201 0.9958701925540472 0.06079498853871145 0.14194638181469924 1.6077511942564254e-07 6.793781159146045 -0.5341155264271752 RGDQGPK(ub)TIDQIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RGDQGPKTIDQIHK 14 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;H7C044 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 2291190.0 832290.0 802920.0 655980.0 True False 1140010.1047915418 767444.3394986242 501051.0343321765 1.0 0.6731908219699125 0.43951455537650425 20.12061518149317 -7.853335197056851 0.15958609582735925 1.314403887874972 1.435833487577698e-14 0.999951555278096 0.0015999208907594806 0.12340500912973909 0.023294256448117966 0.07226452084369378 0.0991847609602245 1.4017314029689656e-08 7.853335197056851 -1.3144038878749575 down RGDQGPK(ub)TIDQIHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGDQGPKTIDQIHK 14 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;H7C044 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 11652900.0 1661100.0 3582300.0 6409500.0 True False 2150326.6951762 3382941.8559052204 5243036.767023706 1.0 1.5732222752450267 2.438251256790581 21.036124431792523 -6.965156883052774 0.35534911919562473 0.921385991484348 3.1195182220513877 0.9999163434301831 0.0054071476952496774 0.07790775656769157 0.014672422440600892 0.011722113030179424 0.07409533853530599 1.0835354306845709e-07 6.965156883052774 2.19813223056704 RGEAHLAVNDFELAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RGEAHLAVNDFELAR 15 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 21848300.0 4817500.0 6451600.0 10579200.0 False True 6315789.1527363695 5489046.428139838 9484565.866852127 1.0 0.8690990619535901 1.5017230052309232 22.590531578176044 -6.8527345994818525 1.221741443649968 0.9299446693575554 1.5283903668003753 0.9442006355316065 0.06440661486018975 0.15447481447186703 0.44232235393248964 0.04121899387383842 0.09556983948031583 1.4036712362199847e-07 6.8527345994818525 0.59844569744282 RGEAHLAVNDFELAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RGEAHLAVNDFELAR 15 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 16588100.0 3792000.0 4133100.0 8663000.0 False True 3671625.03563586 5783468.383831764 6393900.415570745 1.0 1.575179471677769 1.741436108947175 21.80798730050225 -11.339612509756888 0.22596549436702437 4.5604184528184304e-11 1.8395762678262813 0.9993120395785247 0.008332036505882538 3.6750896754617797 0.12777510486460325 1.9173627123372552 0.08774617007908114 4.574961990628098e-12 11.339612509756888 1.839576267780677 RGEAHLAVNDFELAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RGEAHLAVNDFELAR 15 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 75198800.0 8737600.0 51749000.0 14712200.0 False True 13255578.004124392 42513986.63321754 11804327.22141368 1.0 3.207252570954626 0.8905177290451488 23.660096243922784 -6.657122464672309 1.983016379937206 2.4241134701909264 0.9001944866078307 0.2235152633290225 0.9404436641491752 0.49127827009459496 3.7106273967637833 0.38355480188934615 1.0422853862080121 2.202305357685697e-07 6.657122464672309 -1.5239189835830955 RGEAHLAVNDFELAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RGEAHLAVNDFELAR 15 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 20324800.0 4817500.0 8449400.0 7057900.0 False True 6598659.938042332 8076077.569570672 5390969.382013277 1.0 1.2238966161918408 0.8169794219783133 22.653741639698936 -6.757291341638611 1.6224042783804817 1.1304844864135621 0.8156742638395189 0.6799484719276296 0.0941389909117297 0.28747479434177814 1.490676241857975 0.04579343634213123 0.11035665580165985 1.748673217021549e-07 6.757291341638611 -0.31481022257404323 RGEAHLAVNDFELAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RGEAHLAVNDFELAR 15 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 7916900.0 3792000.0 3034200.0 1090700.0 False True 3153216.014083261 3017854.162358455 1318760.327172993 1.0 0.9570718114077065 0.41822708031514233 21.588392575936528 -6.922755088197161 0.8040301569188057 1.0107505299875585 0.3255779654318645 0.9949125897370321 0.018880932605661073 0.09657781813625413 0.09741258364441986 0.01650983813508343 0.050835950364322084 1.1946616203841577e-07 6.922755088197161 -0.6851725645556941 down RGEAHLAVNDFELAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGEAHLAVNDFELAR 15 1 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 41115100.0 8737600.0 20495300.0 11882200.0 False True 11310995.44384537 19354718.538183358 9719761.521667715 1.0 1.7111419268332215 0.8593197274212068 23.431222566015233 -6.6852211096412395 1.883890208366787 1.4478310458908712 0.862459222951776 0.34798576736652487 0.3010619503107785 0.4269938666790391 2.9343612621324153 0.12804119316452714 0.335389849142667 2.0643288893269347e-07 6.6852211096412395 -0.5853718229390952 RGEEGHDPK(ub)EPEQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RGEEGHDPKEPEQLR 15 2 P51991 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 4217000.0 1505800.0 1224900.0 1486300.0 True False 1457999.2032332462 1714008.9577691166 1096993.4419557643 1.0 1.175589776707796 0.7523964618931761 20.475558500585898 -6.7940124960961 1.4801299576400213 1.0976294637072197 0.7473768532362591 0.8140850134988181 0.07485249791103532 0.22943147547634943 0.9928078818381539 0.03979578299837678 0.0929122450260732 1.606895016635782e-07 6.7940124960961 -0.35025261047096057 RGEEGHDPK(ub)EPEQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGEEGHDPKEPEQLR 15 2 P51991 P51991 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 12080500.0 1261000.0 3365300.0 7454200.0 True False 1632389.3580261199 3178018.096663548 6097612.0865509305 1.0 1.9468505360181947 3.7353907366341472 20.638553779756553 -6.961146697726611 0.41896002862052145 0.9200526647282936 4.829541890973879 0.9998103913770149 0.015617809201321385 0.07929401781687351 0.01963641806244617 0.02312143800483529 0.14892553850301274 1.0935869077186487e-07 6.961146697726611 3.9094892262455856 RGEFCIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RGEFCIAK 8 1 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 14976800.0 2859500.0 6110400.0 6006900.0 False True 3748832.1914373934 5198752.138152654 5385363.6102535175 1.0 1.3867657640229893 1.4365443250711731 21.838009817196248 -12.07492882283143 0.32590950958628334 8.087782762561683e-07 1.4465681458345325 0.9995546386891029 0.004117669102365271 5.535693537555687 0.1751612184118525 3.757462799215978 0.016190319053158948 8.41533050447107e-13 12.07492882283143 1.4465673370562562 RGEIIAK(ub)QGGGGGGGSVPGIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 RGEIIAKQGGGGGGGSVPGIER 22 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 7856400.0 1359600.0 3936000.0 2560800.0 True False 1782448.766385131 3348764.142407838 2295832.980928132 1.0 1.8787435608593954 1.2880218630823046 20.76542917864727 -10.61685501411621 7.949842318548529 0.999475178845688 1.58338271197085 0.5652947122003887 0.24116112325740807 0.002245068382919815 0.00010820112634947444 0.2336917090824781 0.0778344178440513 2.416267352146698e-11 10.61685501411621 0.5839075331251619 RGEIIAK(ub)QGGGGGGGSVPGIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 RGEIIAKQGGGGGGGSVPGIER 22 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 23580000.0 4103500.0 6688500.0 12788000.0 True False 3973236.638642339 9359252.930066714 9438439.168223312 1.0 2.3555740020722213 2.3755039094395447 21.921883289563446 -10.814313338473063 0.7391162171068103 1.1862586806388348e-09 2.371692281219618 0.9999744252564229 0.003255648327728591 2.5638888533939013 0.38306283634909266 4.528698525554475 0.003004378287586898 1.533510173621751e-11 10.814313338473063 2.3716922800333595 RGEIIAK(ub)QGGGGGGGSVPGIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 RGEIIAKQGGGGGGGSVPGIER 22 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 75223900.0 8233900.0 10202000.0 56788000.0 True False 12491428.27872184 8381373.3914101785 45563826.90893545 1.0 0.6709699807256777 3.6476074546695214 23.574435109357644 -6.879482160043894 1.0827380973408929 0.7974625447248559 3.8564304811304253 0.9732629330875849 0.217872813055691 0.12808724106646843 0.27509653200280293 0.15508473768458841 0.3745292433038767 1.319829526573304e-07 6.879482160043894 3.0589679364055695 up RGEIIAK(ub)QGGGGGGGSVPGIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RGEIIAKQGGGGGGGSVPGIER 22 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 7009100.0 1359600.0 2048500.0 3601000.0 True False 1862280.8618084807 1957990.4965163793 2750517.9649229664 1.0 1.0513937702259122 1.4769619456068024 20.828639240170162 -6.929459012439253 0.7512108435455458 0.9933972447020326 1.5631399202598475 0.9964310858164049 0.012770139385970823 0.09291922347766986 0.07906074214008205 0.011597099472348209 0.03862159389840127 1.176362001369976e-07 6.929459012439253 0.5697426755578149 RGEIIAK(ub)QGGGGGGGSVPGIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RGEIIAKQGGGGGGGSVPGIER 22 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 16132800.0 4103500.0 8276700.0 3752600.0 True False 3412242.065873064 8232111.774303683 4537251.309937996 1.0 2.4125227974403383 1.3296979588044215 21.702288564997723 -10.225084468298812 5.714728778671098 0.9999675181260517 1.8711103781223992 0.4632072423946233 0.4420613892449898 0.0001829515879949171 2.4808806095433605e-05 0.4280399785266427 0.14267469987892006 5.955463012206989e-11 10.225084468298812 0.8711428599963476 RGEIIAK(ub)QGGGGGGGSVPGIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGEIIAKQGGGGGGGSVPGIER 22 2 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 16785800.0 8233900.0 8551900.0 0.0 True False 10658945.864433998 8075979.247275734 0.0 1.0 0.7576714761469123 0.0 23.345561431450093 -7.320704543719959 0.8055428848145744 0.989112739964426 1.914900003985997e-15 0.9880827656464779 0.0464977072343558 0.10603885225808683 0.1375646618739292 0.03975961714794687 0.0705340499248542 4.7785425366995435e-08 7.320704543719959 -0.9891127399644241 down RGEK(ub)EECFER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGEKEECFER 10 2 E9PF19;Q96E41;Q9Y4P3 E9PF19 TBL2 Transducin beta-like protein 2 1 7449150.0 853950.0 868400.0 5726800.0 True False 1105455.1088710583 820072.7766150488 4684581.16193017 1.0 0.7418417718043249 4.23769461494848 20.076209009653272 -6.889124163536465 1.027572813421241 0.8082001382190195 4.53323585489319 0.9803309295428393 0.22307712140064892 0.11985571151291427 0.22603295429219278 0.16560218925161127 0.4115597125440645 1.2908501705224777e-07 6.889124163536465 3.7250357166741708 up RGERPDYK(ub)GEEELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RGERPDYKGEEELR 14 3 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 35960000.0 12441000.0 12527000.0 10992000.0 True False 16310271.478815362 10658020.429863542 9854653.282709336 1.0 0.6534545083266541 0.6041992186033861 23.959277459620075 -13.999999999999998 0.27482186074004283 3.7453786916946505 0.5885986947634362 0.9995937837869495 0.0035497477024887003 15.125254239678199 0.16600101774186707 23.266935983881744 0.019975785760260344 1.0000000000000041e-14 13.999999999999998 -3.1567799969312142 RGERPDYK(ub)GEEELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RGERPDYKGEEELR 14 3 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 63354000.0 14573000.0 16624000.0 32157000.0 True False 14110388.091856912 23262049.893014777 23734117.010678567 1.0 1.648576193764598 1.682031483200345 23.75025433255051 -11.338215379580319 0.49412966182445733 1.0685452978511007e-18 1.6806854290242939 0.9998324921134355 0.004062958545320793 3.678833069537685 0.2425068724056142 4.006963361461135 0.006882085724357304 4.5897033931287105e-12 11.338215379580319 1.6806854290242939 RGERPDYK(ub)GEEELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RGERPDYKGEEELR 14 3 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 73767000.0 18459000.0 37005000.0 18303000.0 True False 28003652.533662837 30401168.62861532 14685404.02751013 1.0 1.0856144066232238 0.5244103071860713 24.739111675258048 -6.868002897850229 1.1446770504671344 1.0478776417302729 0.49277675017650474 0.962645371307357 0.047711775819224825 0.1387804182962009 0.341119684456843 0.032387036397397324 0.07641904268710906 1.355180369816509e-07 6.868002897850229 -0.5551008915537681 RGERPDYK(ub)GEEELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RGERPDYKGEEELR 14 3 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 32574900.0 12441000.0 8317900.0 11816000.0 True False 17040773.90538339 7950387.674383013 9025304.158158775 1.0 0.46655085728655715 0.5296299456979223 24.022487521142967 -10.24618793688636 5.510909245269106 1.0000351913261736 0.4980904014932429 0.9882924351819375 0.02575193000804441 1.1135263614114906e-05 1.5231423077811185e-06 0.024935942337302654 0.008311399671142153 5.672990589068816e-11 10.24618793688636 -0.5019447898329307 RGERPDYK(ub)GEEELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RGERPDYKGEEELR 14 3 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 55874000.0 14573000.0 24419000.0 16882000.0 True False 12118095.19336376 24287450.00020798 20411948.146451328 1.0 2.0042300058435365 1.6844188645777876 23.530659607984788 -10.150704984078189 4.8005825974666285 0.9999293034159636 1.8443244352154042 0.9028494902715689 0.13056235170936323 9.879802431509738e-05 1.7478480302943892e-05 0.1264269576763446 0.04213881781534996 7.067975182586903e-11 10.150704984078189 0.8443951317994406 RGERPDYK(ub)GEEELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGERPDYKGEEELR 14 3 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 79813000.0 18459000.0 48756000.0 12598000.0 True False 23895539.38128799 46042685.74003145 10305293.266395932 1.0 1.9268318243565723 0.4312643084535583 24.510237997350497 -6.739087434882122 1.6901696955768808 1.5520361496400594 0.43057528412158397 0.6008288807356956 0.3894220469545141 0.3194451847776964 1.7914708683349065 0.1823048285343878 0.4477857207679957 1.8235285411870525e-07 6.739087434882122 -1.1214608655184755 RGFAFVTFDDHDSVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RGFAFVTFDDHDSVDK 16 1 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 14371800.0 4552900.0 5504400.0 4314500.0 False True 5968895.990346319 4683164.975983147 3868076.927606382 1.0 0.7845948368940211 0.6480389227526067 22.509032683973185 -9.85884695303804 0.06804425454190205 1.8361502949191078 5.560432046145753e-10 0.9999845977724259 0.0005685793968430823 1.4313495479795013 0.03064509866533309 0.5171871613458909 0.3154236686079535 1.3840540387395853e-10 9.85884695303804 -1.8361502943630645 RGFAFVTFDDHDSVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RGFAFVTFDDHDSVDK 16 1 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 20922200.0 7275900.0 2946300.0 10700000.0 False True 7044930.5371263055 4122772.9547515246 7897349.0068806335 1.0 0.5852112995330175 1.1209974271942271 22.748154050985068 -6.700040936167172 1.8311667731017474 0.7424411309039024 1.1193832301286704 0.41764290371512724 0.17508589789021098 0.39539778100877754 2.577752160326983 0.07628633273740179 0.19614612715464166 1.9950742523852196e-07 6.700040936167172 0.37694209922476796 RGFAFVTFDDHDSVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RGFAFVTFDDHDSVDK 16 1 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 53967000.0 11055000.0 23485000.0 19427000.0 False True 16771243.22875793 19293918.260857493 15587244.93484341 1.0 1.1504166982548967 0.9294030694227665 23.99948630203947 -6.723457005575989 1.746792669134025 1.0911734299015698 0.9296774133653356 0.5287655683506409 0.06327081354732257 0.3486697505524839 2.080961874572975 0.028739171553930225 0.0718566475523485 1.890353363730698e-07 6.723457005575989 -0.16149601653623424 RGFAFVTFDDHDSVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RGFAFVTFDDHDSVDK 16 1 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 17100100.0 4552900.0 5752200.0 6795000.0 False True 6236230.167496192 5498048.78401832 5190160.947417808 1.0 0.8816301894491737 0.8322593631116129 22.572242745496077 -13.99999999858091 0.1199045627929979 1.5642081843366273 0.7533591329923773 0.9996934039900819 0.00123241101057628 11.96412842545539 0.10655638014027397 1.6087287701202662 0.07001464633641864 1.0000000032675769e-14 13.99999999858091 -0.81084905134425 RGFAFVTFDDHDSVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RGFAFVTFDDHDSVDK 16 1 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 13028900.0 7275900.0 2964500.0 2788500.0 False True 6050233.227022257 2948529.65009282 3371562.457432737 1.0 0.4873414857668219 0.5572615684258703 22.528559326419344 -10.540328315125896 6.304966455258723 1.0006038642223736 0.5223015270965008 0.9841862548069067 0.02854475421464849 0.00024258575484076088 1.7685999392177793e-05 0.02767114176560849 0.009212779807909808 2.8818520755932456e-11 10.540328315125896 -0.4783023371258728 RGFAFVTFDDHDSVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGFAFVTFDDHDSVDK 16 1 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;Q32P51;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 56749000.0 11055000.0 24332000.0 21362000.0 False True 14310915.426628673 22977902.81045299 17474335.19262975 1.0 1.6056207534912434 1.2210494347632594 23.77061262413192 -10.494622219853609 5.801326279667563 0.9995164505646926 1.4133350941272516 0.6063370226713334 0.15700058343213338 0.00098301636546819 8.563438457294077e-05 0.15218661320562601 0.05067172041479168 3.201678946180349e-11 10.494622219853609 0.41381864356255893 RGFCFITFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RGFCFITFK 9 1 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 202483000.0 61679000.0 101340000.0 39464000.0 False True 80861766.30028556 86220467.02022603 35380643.84541859 1.0 1.0662698944769593 0.43754478122615087 26.268954381608324 -6.8808552710308915 1.0750575305032142 1.0415520062481143 0.3922572688183867 0.9743670941960889 0.045159296297569054 0.1268733587756561 0.26775260269578127 0.032334105598423424 0.07836219292712016 1.3156632049160386e-07 6.8808552710308915 -0.6492947374297275 down RGFCFITFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RGFCFITFK 9 1 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 226620000.0 153800000.0 40446000.0 32374000.0 False True 148917703.18586355 56596298.72310364 23894278.200818103 1.0 0.3800508436022952 0.16045290579720906 27.14994002934054 -11.021795317199048 0.20460282609117184 2.0096652593230706 8.456992660855799e-15 0.999354931745194 0.00902896593520135 3.1259026590390406 0.11411955680492987 1.61262477832718 0.13108879047852665 9.510529188755355e-12 11.021795317199048 -2.009665259323062 RGFCFITFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RGFCFITFK 9 1 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 276326000.0 54432000.0 70304000.0 151590000.0 False True 82577323.5122345 57757701.91234091 121628170.05574259 1.0 0.6994378051473615 1.4729003663786997 26.29924232299927 -6.801324915014313 1.4504351606155454 0.8344412597488147 1.4839371466835067 0.8360164767097119 0.1289222470290216 0.2188770873965037 0.9089199124103763 0.06992000449340144 0.16248321355723858 1.5800654797144127e-07 6.801324915014313 0.6494958869346921 RGFCFITFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RGFCFITFK 9 1 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 322755000.0 61679000.0 85306000.0 175770000.0 False True 84483393.11230142 81536898.8507817 134256746.0967813 1.0 0.9651233910834638 1.5891495494069179 26.332164443131216 -6.893669504639743 1.0004073245474383 0.9693585059048534 1.6468477575965343 0.9831447426307937 0.03717002603271726 0.11621836712623379 0.2048556996188645 0.028164238577162135 0.07120897995318763 1.2774105403842066e-07 6.893669504639743 0.677489251691681 RGFCFITFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RGFCFITFK 9 1 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 270888000.0 153800000.0 24752000.0 92336000.0 False True 127891514.49525446 24618656.063112702 111643030.68657312 1.0 0.19249639947008526 0.8729510407878995 26.930345304774818 -10.711036031468746 9.383687671513565 1.0009078751034943 0.5327237201317203 0.3860376079408411 0.2777944440561988 0.005284465864189294 0.00016273109391081863 0.26939219821575394 0.08965777129155046 1.9451986905014735e-11 10.711036031468746 -0.468184154971774 RGFCFITFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGFCFITFK 9 1 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 459792000.0 54432000.0 234270000.0 171090000.0 False True 70463297.01512913 221232668.5601192 139953375.5316462 1.0 3.139686587651703 1.9861882917797173 26.07036864509172 -10.333655341497545 5.88655850924356 0.9998131621911545 2.5629374397157134 0.7099657025362525 0.470913707342729 0.001154830845662449 0.00013072414070925266 0.456011778727609 0.15198674550326355 4.638148597549237e-11 10.333655341497545 1.563124277524559 RGFCFITYTDEEPVKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RGFCFITYTDEEPVKK 16 2 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 60477000.0 18830000.0 20997000.0 20650000.0 False True 24686312.34997942 17864329.445664946 18513336.088787075 1.0 0.7236532209590971 0.7499433623913663 24.55720800649455 -10.086365042361754 5.190350433317609 1.000004766536995 0.7367982916747751 0.9925726798576153 0.010732905297370218 5.920111254636442e-07 1.0420259180488764e-07 0.01039227913826309 0.0034640302891987868 8.196622948517995e-11 10.086365042361754 -0.26320647486222004 RGFCFITYTDEEPVKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RGFCFITYTDEEPVKK 16 2 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 137867000.0 26345000.0 62676000.0 48846000.0 False True 39967291.07748781 51490978.110176854 39191566.69003764 1.0 1.288327948230145 0.9805910191424729 25.252316456596724 -6.660876577211283 1.9700165501455495 1.1854645295978754 0.9818793516781339 0.2391992154082605 0.12273893944270887 0.48239590802293975 3.5999555408779407 0.050322790144975565 0.13605506393845718 2.1833503132249745e-07 6.660876577211283 -0.2035851779197415 RGFCFITYTDEEPVKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RGFCFITYTDEEPVKK 16 2 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 52653000.0 18830000.0 15665000.0 18158000.0 False True 25791959.861616425 14972868.502772333 13869454.37574873 1.0 0.580524651213301 0.5377433297106375 24.620418068017443 -13.999999999999998 0.3226237477754835 5.3687568166984 0.5294964149258337 0.999699332544409 0.0036163563815394444 18.21912170118669 0.1812605053993938 53.7999324806578 0.014098782254072446 1.0000000000000041e-14 13.999999999999998 -4.839260401772567 RGFCFITYTDEEPVKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RGFCFITYTDEEPVKK 16 2 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 16047900.0 10317000.0 0.0 5730900.0 False True 8579042.620595206 0.0 6929204.693312276 1.0 0.0 0.8076897387918017 23.032385228286216 -9.734336564067677 10.413322895045043 1.0000030641084363 0.40384486939590086 0.42075566525359875 0.32973795509170273 0.0 0.0 0.3192674021685191 0.10642246738950636 1.8435861462592525e-10 9.734336564067677 -0.5961581947125354 RGFCFITYTDEEPVKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGFCFITYTDEEPVKK 16 2 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 0 154456000.0 26345000.0 71423000.0 56688000.0 False True 34104121.83758774 67448247.26413713 46371365.667999074 1.0 1.9777154088688274 1.359699742125922 25.023442778689173 -10.219478090939056 4.974499631332896 0.9999123961691659 1.668707575498079 0.609532652525618 0.25230383943016116 177702838.39986175 28.55369427747966 178316.03839877088 0.08637031512528208 6.032841413218854e-11 10.219478090939056 0.668795179328913 RGFGFVTFDDHDPVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RGFGFVTFDDHDPVDK 16 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 29898800.0 10947000.0 8148800.0 10803000.0 False True 14351623.010898806 6933030.80377362 9685209.189693304 1.0 0.4830833975020517 0.674851142782822 23.774710563298598 -10.089896091499222 5.125280381830099 1.0000091154507778 0.5789672701414778 0.8653590911392116 0.07828885418032552 8.154695192030046e-06 1.4480122293582682e-06 0.07580449746172514 0.025267619035691906 8.130250157686747e-11 10.089896091499222 -0.4210418453093 RGFGFVTFDDHDPVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RGFGFVTFDDHDPVDK 16 1 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 29835700.0 10947000.0 6791700.0 12097000.0 False True 14994401.731551504 6491620.236851498 9239937.745535426 1.0 0.43293626201782415 0.616225836212763 23.83792062482149 -10.25546698346283 6.2371649743159026 1.0000107969536343 0.5245810491152954 0.8997040310936715 0.07482765532493482 1.1234653275370312e-05 1.3411024706375566e-06 0.07245320985130674 0.024150521909101517 5.553068318206875e-11 10.25546698346283 -0.4754297478383389 RGFVFITFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RGFVFITFK 9 1 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 50947000.0 13923000.0 26898000.0 10126000.0 False True 18253187.83052381 22884923.24758281 9078258.655450745 1.0 1.2537493976429477 0.4973519551620275 24.12164510988431 -6.816217821599369 1.3880165692218818 1.137314148189395 0.4821210932086868 0.8755036552686745 0.11090525094610318 0.19843472954903807 0.7521767358917661 0.06280306869868515 0.14492701840830627 1.5268000953552705e-07 6.816217821599369 -0.6551930549807081 down RGFVFITFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RGFVFITFK 9 1 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 81126000.0 40646000.0 18953000.0 21527000.0 False True 39355714.978495575 26521031.738589317 15888432.903842922 1.0 0.6738800642570137 0.40371348640278926 25.230069813857007 -7.409909620887032 0.20196865024015923 1.188099781806155 4.86610328701165e-13 0.9999631020118197 0.0014808593695917606 0.1210095464002724 0.015870136212354922 0.02569861504863385 0.057435016590627 3.891261158918773e-08 7.409909620887032 -1.1880997818056684 down RGFVFITFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RGFVFITFK 9 1 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 386501000.0 99581000.0 131640000.0 155280000.0 False True 151071657.34626353 108147813.49198563 124588839.93835835 1.0 0.71587096740526 0.8247002920792397 27.170657780015716 -10.212210551695536 6.2636270090756225 1.0000026715829575 0.7702856298695343 0.8559182152068951 0.04442938575049022 1.6575905052233437e-06 2.0847371702565607e-07 0.04301906835518695 0.014339522591155958 6.134645173646592e-11 10.212210551695536 -0.22971704171342322 RGFVFITFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RGFVFITFK 9 1 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 78687000.0 13923000.0 26528000.0 38236000.0 False True 19070709.354927532 25355905.24363512 29205444.295138724 1.0 1.3295732618925162 1.5314293638266034 24.1848551714072 -9.944405270320978 0.08572904093180451 4.8761251553706714e-17 2.232245459992388 0.9999605055269517 0.001376496614365963 1.5549239858218962 0.03997091431525915 0.695673596531249 0.361489680129053 1.1365661820238172e-10 9.944405270320978 2.232245459992388 RGFVFITFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RGFVFITFK 9 1 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 73543000.0 40646000.0 14556000.0 18341000.0 False True 33798949.92310872 14477583.938860208 22176018.300797515 1.0 0.4283441932899141 0.6561155997818596 25.010475089291283 -10.246502400293553 5.562627784598639 1.0000294591859773 0.5422298965358746 0.8433979747563807 0.092987287316946 3.3974505150453236e-05 4.602149908674197e-06 0.09004033407756515 0.030011517932286014 5.668884383900725e-11 10.246502400293553 -0.4577995626501027 RGFVFITFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGFVFITFK 9 1 D6R9P3;D6RD18;D6RBZ0;Q99729-3;Q99729-2;Q99729-4;Q99729 D6R9P3 HNRNPAB Heterogeneous nuclear ribonucleoprotein A/B 0 357941000.0 99581000.0 163320000.0 95040000.0 False True 128909567.53497149 154231098.43018162 77743695.19275028 1.0 1.1964286389242655 0.603087084065032 26.941784102108166 -6.817489715019389 1.382795768119507 1.106148513474523 0.5908273463525688 0.8784946853601237 0.08602749777897026 0.1967612762252749 0.7399588610633325 0.04889792278206266 0.11277905088322271 1.5223351844608864e-07 6.817489715019389 -0.5153211671219542 RGGFEEPVLLK(ub)NIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RGGFEEPVLLKNIR 14 2 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8YG48;A0A2R8Y7R5;A0A2R8Y755 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 23371600.0 6077200.0 3355400.0 13939000.0 True False 9219556.702831998 2756602.6541401446 11183950.54031926 1.0 0.2989951407634806 1.213068144250781 23.13626595360124 -6.7017873579937675 1.8243191916409571 0.5654749962317167 1.2104587081306322 0.42615119044197713 0.2958064268534311 0.39181303075680163 2.5363621201478685 0.12929145359421573 0.33179361054382817 1.9870675997964327e-07 6.7017873579937675 0.6449837118989155 RGGFEEPVLLK(ub)NIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGGFEEPVLLKNIR 14 2 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8YG48;A0A2R8Y7R5;A0A2R8Y755 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 1 37683600.0 6077200.0 8308400.0 23298000.0 True False 7867055.199521286 7846030.2363294205 19058003.05766727 1.0 0.9973274671832549 2.422507860225381 22.907392275693688 -6.906475177008453 0.9194105602859727 0.9508054213681235 2.593446405909175 0.9895218763573552 0.068706610320133 0.10679510021649147 0.15175484164477446 0.05528852134692707 0.14913817608311286 1.2402945146689115e-07 6.906475177008453 1.6426409845410515 up RGIFVIGFSYPVVPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RGIFVIGFSYPVVPK 15 1 O75600;O75600-2 O75600 GCAT 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial 0 11068100.0 3515000.0 3673100.0 3880000.0 False True 5332511.980921226 3017606.606938712 3113116.2993355882 1.0 0.5658883876370402 0.5837992132926774 22.34638387129578 -10.28007998139935 8.58685270714702 1.0000002797057197 0.5748438004746363 0.9986707152282045 0.007312063954710175 3.915626570595476e-08 3.2803754397605566e-09 0.0070798801224609366 0.0023599584935830066 5.2471081851951826e-11 10.28007998139935 -0.42515647923108335 RGIFVIGFSYPVVPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGIFVIGFSYPVVPK 15 1 O75600;O75600-2 O75600 GCAT 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial 0 9714900.0 3515000.0 2415400.0 3784500.0 False True 4550236.791008576 2280980.866692759 3095759.8322491962 1.0 0.5012883881559869 0.6803513694862043 22.11751019338823 -10.077414283908611 4.959935535357833 1.0000100061218 0.5908198788206283 0.874409016271475 0.0731021560233964 8.781511100416515e-06 1.6333244188979408e-06 0.07078273662069473 0.02359361940276795 8.367307238264633e-11 10.077414283908611 -0.40919012730117177 RGILTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RGILTLK 7 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38;P0CG39 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 232168000.0 64800000.0 65998000.0 101370000.0 False True 84953427.52409266 56151355.65818901 90881204.80970198 1.0 0.6609663352578043 1.0697767878044497 26.34016881965231 -6.6865633194223655 1.8790087017883175 0.7867596319007798 1.0682929005546558 0.3542014777224357 0.14349004283845085 0.4241075101287139 2.9004984621992542 0.06115808114165993 0.15993080687412867 2.0579588216507089e-07 6.6865633194223655 0.28153326865387596 RGILTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RGILTLK 7 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38;P0CG39 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 172039000.0 59144000.0 18518000.0 94377000.0 False True 57266506.093788825 25912333.970094293 69656832.45068914 1.0 0.4524867280650245 1.2163625337401922 25.77118824960349 -6.714320378441598 1.7797948166815938 0.6648937969516747 1.2148060544868997 0.4855723585179259 0.23057028077844946 0.3664706278128823 2.265446953143481 0.10299229992284815 0.26028819643699563 1.9305436322069726e-07 6.714320378441598 0.549912257535225 RGILTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RGILTLK 7 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38;P0CG39 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 228153000.0 64800000.0 60193000.0 103160000.0 False True 88758311.15415521 57533474.22836727 78795732.64689064 1.0 0.6482037961317592 0.8877561055667047 26.4033788811752 -10.300606346630225 5.2081463732028705 1.0000528420316193 0.7679799508492082 0.5557141876684462 0.09779682080358561 6.001908205603391e-05 8.05985948341469e-06 0.09471289155869676 0.03156378819034564 5.004879819464522e-11 10.300606346630225 -0.23207289118241103 RGILTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RGILTLK 7 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38;P0CG39 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 122206000.0 59144000.0 39208000.0 23854000.0 False True 49180856.523454726 38996778.72182133 28841761.11156555 1.0 0.7929259772697018 0.5864428387458176 25.551593525037767 -6.971160511460578 0.22877462981572558 1.0852735814169527 0.2882040365691427 0.9999900728946843 0.0005319193658008234 0.07592790113766629 0.007669036448772373 0.0053537449394240955 0.020556985873187147 1.068659838850181e-07 6.971160511460578 -0.79706954484781 RGILTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGILTLK 7 1 C9JTX5;C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65;P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6;Q6S8J3;A5A3E0;P0CG38;P0CG39 C9JTX5;C9JUM1;K7EM38;P60709;P63261;P68133;Q6S8J3 ACTB;ACTG1;ACTA1;ACTC1;ACTG2;ACTA2;POTEE;POTEF;POTEI;POTEJ Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle;POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member J 0 242069000.0 59266000.0 85777000.0 97026000.0 False True 76721005.30751471 81003434.54595694 79368263.57083115 1.0 1.0558182106878984 1.0345049996764986 26.193118288929725 -10.53185095132361 6.8966523520215475 0.9999733248187784 1.045161605182196 0.8568686582397791 0.008701081959699559 3.570900452291645e-06 2.4238466257065393e-07 0.008429761193472439 0.002808262126991859 2.9386580182984395e-11 10.53185095132361 0.04518828036341749 RGLCGTVLIHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RGLCGTVLIHK 11 1 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 21379300.0 9120000.0 5218400.0 7040900.0 False True 11956408.318205623 4439835.061163886 6312375.209081894 1.0 0.37133518218874295 0.527949116581294 23.511280736045062 -10.382059771509384 8.92333662793452 1.0000016848315731 0.44964214938583463 0.9427434397331782 0.06393737097857854 2.1430828569732637e-06 1.484534704060148e-07 0.061907283208271664 0.020635697750026685 4.1489693685982867e-11 10.382059771509384 -0.5503595354457385 RGLCGTVLIHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RGLCGTVLIHK 11 1 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 11174700.0 5127200.0 1300800.0 4746700.0 False True 4964439.842487391 1820216.223582388 3503396.8720523617 1.0 0.3666508773063073 0.7056983231157483 22.243199511235634 -10.635234668481086 6.738911778600681 1.0016152254117519 0.5361746002111378 0.7139034391990029 0.13841554013784352 0.003368574425045504 0.0001823348599726456 0.1344023973699339 0.044673423484181025 2.316142797580612e-11 10.635234668481086 -0.465440625200614 RGLCGTVLIHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RGLCGTVLIHK 11 1 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 22239300.0 7024300.0 15215000.0 0.0 False True 10656376.645116637 12499764.374662401 0.0 1.0 1.1729844759560475 0.0 23.34521364407935 -6.9263906200367265 1.2469766487522813 1.0919130458236572 2.9038005747257233e-21 0.9623840280169857 0.1002757946054201 0.11881617560879003 0.3692595374055227 0.06629721762344366 0.12867243912802798 1.184702704708008e-07 6.9263906200367265 -1.0919130458236572 down RGLCGTVLIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RGLCGTVLIHK 11 1 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 21917000.0 9120000.0 7214500.0 5582500.0 False True 12491910.458732946 6895739.534838868 4264028.475196456 1.0 0.5520164075478254 0.34134318279679343 23.574490797567954 -11.731558438721864 0.12864023761566787 2.2412768956936233 4.085130003118628e-13 0.999731297536762 0.00450212485957263 4.826682980956093 0.08635894514814178 1.9061461848986656 0.2521584561519092 1.8554171274657957e-12 11.731558438721864 -2.2412768956932148 RGLCGTVLIHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGLCGTVLIHK 11 1 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 59428300.0 7024300.0 28315000.0 24089000.0 False True 9093094.819653358 26739245.359114613 19705049.17401265 1.0 2.940609978169561 2.167034388712537 23.1163399661718 -10.460279237507901 5.930860088418678 0.9990218781114834 2.5538221834410493 0.8432460607454789 0.3158109119404069 0.004086342446983007 0.00037186521506071623 0.3059200598815299 0.10192753354131413 3.4651398136712396e-11 10.460279237507901 1.5548003053295658 RGPCIIYNEDNGIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RGPCIIYNEDNGIIK 15 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 40795900.0 3444900.0 17586000.0 19765000.0 False True 4718572.624922056 16808992.37087483 15096914.072952624 1.0 3.5623044736229934 3.199466294789095 22.169919077559456 -9.962057843609559 13.410117014772618 1.000000000044191 3.3808853842060462 0.9828797295302121 0.1481280662239604 0.0 1.9572448583103246e-18 0.14342438339782704 0.04780812779927569 1.091294977372902e-10 9.962057843609559 2.3808853841618554 RGPCIIYNEDNGIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGPCIIYNEDNGIIK 15 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 16452700.0 5446200.0 5859600.0 5146900.0 False True 7050213.260651754 5533508.108997635 4210217.011653695 1.0 0.7848710250909618 0.5971758379496854 22.74923546732232 -6.972724233585646 0.18168812383134675 1.1418921845423506 0.23507048099579833 0.9999965729229346 0.0003046206153688729 0.07542825241660193 0.0057407738181466435 0.007121066317679774 0.02095653946964501 1.064818937686357e-07 6.972724233585646 -0.9068217035465523 RGPCIIYNEDNGIIK(ub)AFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RGPCIIYNEDNGIIKAFR 18 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 15535900.0 2450400.0 3149200.0 9936300.0 True False 3212498.1297073527 2679351.635485456 8908186.991719862 1.0 0.834039905177948 2.772978109883403 21.615264183704554 -6.886078986464546 1.0452591203072457 0.8858174756505236 2.9274997647771066 0.9782691764145677 0.1293595076629217 0.12238387570363897 0.24087296921906493 0.09474616108068083 0.2331124430879204 1.2999331337211363e-07 6.886078986464546 2.041682289126583 up RGPCIIYNEDNGIIK(ub)AFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RGPCIIYNEDNGIIKAFR 18 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 24956600.0 2450400.0 5068800.0 17437400.0 True False 3356379.0995700886 4844843.655719912 13319045.254525898 1.0 1.4434733121596657 3.9682779743896948 21.678474245227445 -6.936955310360544 0.6873019248086684 0.9696198931958985 4.592198931333634 0.9977373387407468 0.0621862907951813 0.08918344263019504 0.06114260694656923 0.05921893352724995 0.2203773430738885 1.1562312142255707e-07 6.936955310360544 3.6225790381377356 up RGPCIIYNEDNGIIK(ub)AFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGPCIIYNEDNGIIKAFR 18 2 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 151733900.0 14981900.0 22289000.0 114463000.0 True False 19394364.887400106 21048597.55639434 93631908.48955998 1.0 1.0852945006757573 4.827789362176516 24.2091341965232 -6.91181242938796 0.8833076412948013 0.8906618651489657 5.330663941896806 0.9915876360701905 0.1636883008707328 0.10323146403589678 0.13235852887145175 0.13522659716390603 0.3781418057679668 1.2251452219226327e-07 6.91181242938796 4.440002076747841 up RGQTCVVHYTGMLEDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RGQTCVVHYTGMLEDGK 17 1 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 17599800.0 3402000.0 8743400.0 5454400.0 False True 4460054.945014866 7438918.801506255 4890031.010299285 1.0 1.6678984660987084 1.096406001850945 22.088630052656345 -10.297677639903247 4.832654987162895 0.9998457750114808 1.382152233975183 0.37351131200499543 0.23331082154335853 0.000387838865869349 5.636378378346996e-05 0.2259927206690715 0.07530074386044165 5.0387447666861287e-11 10.297677639903247 0.3823064589637023 RGQTCVVHYTGMLEDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RGQTCVVHYTGMLEDGK 17 1 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 19594800.0 3402000.0 6786800.0 9406000.0 False True 4659811.335593151 6486936.735053636 7184496.522650757 1.0 1.3921028702394684 1.5417998724054 22.151840114179237 -11.946324631062637 0.16197400350714677 4.273119918678497e-18 1.7036273652141236 0.9995417193289455 0.0048905188205896 5.242170679371259 0.1071743016546653 1.9056465373474847 0.1292961371444622 1.1315542208381805e-12 11.946324631062637 1.7036273652141236 RGQTCVVHYTGMLEDGK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 RGQTCVVHYTGMLEDGKK 18 2 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 1 18393500.0 4786400.0 5540400.0 8066700.0 True False 7261318.732711619 4551672.332657225 6472313.209239782 1.0 0.6268382507646072 0.8913412904026049 22.791800150103477 -10.098342966518256 5.794064852962322 1.000001437460482 0.7590897705835867 0.5251850000522271 0.10798291375477631 2.0050516026518775e-06 3.1218701545527435e-07 0.10455462981586013 0.03485133555392339 7.973647519745201e-11 10.098342966518256 -0.24091166687689525 RGQTCVVHYTGMLEDGK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RGQTCVVHYTGMLEDGKK 18 2 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 1 7057670.0 3719600.0 2412400.0 925670.0 True False 3093012.2062194315 2399403.9223760907 1119223.3171854988 1.0 0.7757499041068662 0.3618554478818298 21.5605810961938 -6.961584494553844 0.41249814594737777 1.0198416395197862 0.10234106125205006 0.9998245200921093 0.003501521692873759 0.07913992491161102 0.019075435799073167 0.005333905094057966 0.03452966030263691 1.0924850570975448e-07 6.961584494553844 -0.9175005782677361 down RGQTCVVHYTGMLEDGKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RGQTCVVHYTGMLEDGKK 18 2 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 22879700.0 7234600.0 6603300.0 9041800.0 False True 9484630.659966066 5618113.379461805 8106241.271069982 1.0 0.592338656177246 0.8546712636144953 23.177160164214488 -10.101747826752899 5.04730424652962 1.0000080897543955 0.7235049598950696 0.5969665328577829 0.10709683852196736 9.749502528285141e-06 1.735314357108902e-06 0.10369910034057361 0.03456535600185501 7.911378691458884e-11 10.101747826752899 -0.2765031298593259 RGQTCVVHYTGMLEDGKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RGQTCVVHYTGMLEDGKK 18 2 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 12626200.0 3488600.0 1343500.0 7794100.0 False True 3377856.3025630945 1879966.5562599439 5752591.392011991 1.0 0.5565561077401184 1.7030302288605241 21.68767652505697 -6.801824956181419 1.4483865669872351 0.7558952157635604 1.7195907652505753 0.8374639651996212 0.19030180890615145 0.2181615383069657 0.9033330488933874 0.10335261972687702 0.24010474766234446 1.5782472592678918e-07 6.801824956181419 0.9636955494870149 RGQTCVVHYTGMLEDGKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RGQTCVVHYTGMLEDGKK 18 2 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 21647000.0 7234600.0 5835300.0 8577100.0 False True 9909427.12771376 5577477.151243362 6551365.630919398 1.0 0.5628455691091158 0.6611245581086267 23.24037022573738 -10.345927442710114 5.832994727787762 1.000059380884946 0.6119850636088824 0.9540932478964146 0.040122229247570404 3.098786593264482e-05 3.4747592465791223e-06 0.03885410155408339 0.012949393807379212 4.508920284800652e-11 10.345927442710114 -0.3880743172760637 RGQTCVVHYTGMLEDGKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RGQTCVVHYTGMLEDGKK 18 2 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 0 7792000.0 3488600.0 1844100.0 2459300.0 False True 2900925.471184298 1834165.467274809 2973528.2594815586 1.0 0.6322690760221475 1.025027457278184 21.468081800491245 -9.188539953057916 14.928904684029366 1.000001690843965 0.8286482666501656 0.2024146661748667 0.1603429377161027 0.0 0.0 0.15525138186276696 0.05175046062092231 6.478284953404966e-10 9.188539953057916 -0.1713534241937995 RGQTCVVHYTGMLEDGKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 RGQTCVVHYTGMLEDGKK 18 2 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 1 22596600.0 10487000.0 9275400.0 2834200.0 True False 13748558.556252478 7891546.475226017 2540944.1715661217 1.0 0.5739908255063693 0.18481531435966922 23.712777033921082 -7.772849734264429 0.35700677170340306 1.0688981078120814 2.8006029079859264e-12 0.9988036195712174 0.011514967342758727 0.11715079580634899 0.05868764296443208 0.034714116985354426 0.0792719648462032 1.6871366730980712e-08 7.772849734264429 -1.0688981078092807 down RGQTCVVHYTGMLEDGKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 RGQTCVVHYTGMLEDGKK 18 2 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 1 34469800.0 20010000.0 9342500.0 5117300.0 True False 19374793.50292022 13073008.970493894 3776925.6142906775 1.0 0.6747431382184019 0.1949401738770227 24.207677598397094 -7.324313084074817 0.44087644812038396 1.0220720944142199 7.928360702428673e-12 0.9990922254490651 0.00996305751366999 0.10387590029808035 0.04030824155079529 0.013355076801579586 0.055609963692299445 4.739002261238062e-08 7.324313084074817 -1.0220720944062915 down RGQTCVVHYTGMLEDGKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 RGQTCVVHYTGMLEDGKK 18 2 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 1 96030000.0 28796000.0 29294000.0 37940000.0 True False 43685637.26958966 24066256.824933313 30441142.370307263 1.0 0.5508963203722395 0.6968226692551392 25.380655700325516 -10.362409148377449 4.970633522016643 1.0002547531971526 0.6238594948136091 0.8985670654987565 0.05957418246535497 0.00016829900687441993 2.1587996483051804e-05 0.0577210245931703 0.019227484712647087 4.3410106530788886e-11 10.362409148377449 -0.3763952583835435 RGQTCVVHYTGMLEDGKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RGQTCVVHYTGMLEDGKK 18 2 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 1 36929000.0 20010000.0 11848000.0 5071000.0 True False 16639201.593303265 11784172.472356142 6131322.654345135 1.0 0.7082174229500824 0.3684865899342666 23.98808287383137 -6.993531615655146 0.2815217382978141 1.0745392068579316 5.351179972638213e-10 0.9999749080233638 0.0012926677791027614 0.07398201730483975 0.010064420163007537 0.006213178410158271 0.030223420806447368 1.0150054737823421e-07 6.993531615655146 -1.0745392063228136 down RGQTCVVHYTGMLEDGKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGQTCVVHYTGMLEDGKK 18 2 P62942;Q5W0X3;A0A087WZM5 P62942 FKBP1A Peptidyl-prolyl cis-trans isomerase FKBP1A;Peptidyl-prolyl cis-trans isomerase 1 94648000.0 28796000.0 38646000.0 27206000.0 True False 37276989.654020764 36495316.12743577 22254787.157133464 1.0 0.979030669218734 0.597011383260478 25.151782022417965 -6.918226804472219 0.8377715015730808 1.0089797242456233 0.53785143615807 0.9936740295191671 0.01473213396845327 0.09922647268874035 0.11110305717984753 0.012575463202263262 0.03705405233516484 1.2071832351955264e-07 6.918226804472219 -0.47112828808755336 RGTGQSDDSDIWDDTALIK(ub)AYDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGTGQSDDSDIWDDTALIKAYDK 23 2 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;Q16637-4;Q16637-2;B4DP61 A0A1W2PRV5 SMN1;SMN2 Survival motor neuron protein 1 14355500.0 4542200.0 4671700.0 5141600.0 True False 5879967.440147694 4411715.788245659 4205881.557271101 1.0 0.7502959554032573 0.7152899399669901 22.487376735598822 -13.999999999999998 0.27679032963336675 2.9995329989854467 0.7044139687886668 0.9995980968382994 0.0025414324066839232 15.227327838369257 0.16661661995861066 17.20267470471983 0.014061858785396862 1.0000000000000041e-14 13.999999999999998 -2.29511903019678 RGVLLMLFGGVPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RGVLLMLFGGVPK 13 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 4754200.0 2008700.0 2745500.0 0.0 False True 3047344.7556405314 2255544.074310593 0.0 1.0 0.7401670159359742 0.0 21.539121295182813 -7.351940466201312 0.7870605724385681 0.9894803834843766 7.988059632034191e-23 0.9878062032897924 0.046782446763119094 0.10906470324425863 0.13793793729081963 0.04018917361298941 0.07156931796427447 4.4469222242909466e-08 7.351940466201312 -0.9894803834843766 down RGVLLMLFGGVPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RGVLLMLFGGVPK 13 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 2008700.0 2008700.0 0.0 0.0 False True 2600301.747396566 0.0 0.0 1.0 0.0 0.0 21.310247617275262 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 RIEVNVELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RIEVNVELR 9 1 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 0 7172800.0 3026500.0 1175300.0 2971000.0 False True 2930425.41412234 1644603.4191085338 2192805.971910502 1.0 0.5612166107974774 0.7482892966130126 21.482678687314188 -10.223743777363008 5.492524128886456 1.0000188158541803 0.6547529537052206 0.8195361560452901 0.0763721041767617 1.7597662710791603e-05 2.4871238249768605e-06 0.07395099741527532 0.024648990632605512 5.973876260588199e-11 10.223743777363008 -0.3452658621489597 RIEVNVELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RIEVNVELR 9 1 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 0 124971000.0 26793000.0 55842000.0 42336000.0 False True 40646939.83067497 45876558.80446262 33968271.04347199 1.0 1.1286595988670474 0.8356907355135553 25.276643405016234 -6.787333763253058 1.506986127105537 1.0721573379815268 0.832800137185896 0.7925730252522026 0.05460690822841603 0.23934465480982778 1.0738425476362468 0.028526566772701316 0.06691920476971831 1.631797399735442e-07 6.787333763253058 -0.23935720079563083 RIEVNVELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RIEVNVELR 9 1 P52292;J3QLL0;J3KS65 P52292 KPNA2 Importin subunit alpha-1 0 95663000.0 26793000.0 45367000.0 23503000.0 False True 34684066.66898802 42842286.56920192 19225695.161144886 1.0 1.23521520639644 0.5543091398314924 25.047769727108683 -6.813430665077856 1.400120083316302 1.1276786152258451 0.5414443043469543 0.8685897427770968 0.10236098907668743 0.20215473776333215 0.7803863090654639 0.05747602832144599 0.13275586168932957 1.5366300960657207e-07 6.813430665077856 -0.5862343108788908 RILGLLDAYLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RILGLLDAYLK 11 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 26545800.0 7520400.0 7081400.0 11944000.0 False True 11408996.614884786 5817668.842769273 9583263.164758818 1.0 0.5099194117718671 0.8399742315863239 23.443668580957944 -9.935940247561547 5.5581367624928415 1.0000003960634707 0.6749468216784432 0.5639336364645744 0.1347443159509153 6.613403100059763e-07 1.2661833785394498e-07 0.13046578232948425 0.04348854097249908 1.1589367975916123e-10 9.935940247561547 -0.32505357438502747 RILGLLDAYLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RILGLLDAYLK 11 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 28601400.0 7520400.0 10083000.0 10998000.0 False True 9735306.049246352 9521872.186330657 8996476.849009551 1.0 0.9780763068119243 0.9241082718407198 23.214794903050393 -6.955792542777885 0.4911578636058626 1.0011687509429994 0.8987228553451199 0.9995808835538544 0.0006528372961503631 0.08123983192467255 0.02695669814321894 0.000778971154042344 0.004451128983737857 1.1071525310549441e-07 6.955792542777885 -0.10244589559787953 RILVATNLFGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RILVATNLFGR 11 1 O00148;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 317459000.0 44038000.0 98056000.0 175365000.0 False True 66808865.60904947 80557140.68497524 140704030.88478988 1.0 1.2057851895941116 2.1060682530991977 25.993536226813927 -6.9428232680518684 0.632762872518181 0.9901763911355987 2.3704268750452457 0.9985107006152159 0.018535697660459195 0.0865021170261726 0.04892110937647398 0.01845532208638151 0.07657407667230856 1.1407138956336667e-07 6.9428232680518684 1.380250483909647 up RILVATNLFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RILVATNLFGR 11 1 O00148;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 24038900.0 8197200.0 14028300.0 1813400.0 False True 11227926.361000637 13408483.320615435 1385112.2681453223 1.0 1.1942083417280684 0.12336314147520652 23.420588171207424 -6.859950983806849 1.1859592645000563 1.1053583489166194 0.07155073389513254 0.9535809717615809 0.10036188903024429 0.14685557268751073 0.39251249693253 0.06600381407372613 0.154066539492284 1.380540069023512e-07 6.859950983806849 -1.033807615021487 down RILVATNLFGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RILVATNLFGR 11 1 O00148;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 0 336130000.0 44038000.0 138984000.0 153108000.0 False True 57008059.11875836 131249418.22324498 125243915.02074523 1.0 2.3022958552198403 2.1969510444100355 25.764662548906376 -10.10335648268116 4.496118935259032 0.9998912159508352 2.249623449816905 0.9946982336027909 0.04300683931601194 3309146.234213085 3718043.1143699596 3089.9633820358968 0.014722385162622257 7.8821286190154e-11 10.10335648268116 1.24973223386607 RINVELSTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RINVELSTK 9 1 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 0 27177900.0 6156900.0 10229000.0 10792000.0 False True 9340467.429682475 8403555.030458212 8658956.46969837 1.0 0.8996931999091492 0.9270367393158103 23.15506331857506 -10.699488280789682 6.679226541920213 1.0008521335821225 0.9133649696124797 0.9304828218290204 0.011162953218000673 0.0001430188067532337 6.434708894621042e-06 0.010912973489234848 0.0036028276589840937 1.997614672306556e-11 10.699488280789682 -0.08748716396964284 RINVELSTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RINVELSTK 9 1 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 0 27424900.0 6156900.0 12477000.0 8791000.0 False True 7970228.420643159 11782643.981835518 7191128.203277235 1.0 1.4783320326576932 0.9022486964930605 22.92618964066751 -6.686265202684971 1.8794908557081937 1.300924849573518 0.9043145496871757 0.353070823136148 0.20245649397435617 0.4247584465794952 2.9060478582954565 0.08626478999690557 0.22571905318410718 2.0593719701310262e-07 6.686265202684971 -0.3966102998863422 RISVFIQTDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RISVFIQTDK 10 1 Q6YHK3;Q6YHK3-4;Q6YHK3-3 Q6YHK3 CD109 CD109 antigen 0 19407500.0 3553000.0 7496300.0 8358200.0 False True 5390160.759093347 6158526.696140777 6706198.1064707935 1.0 1.1425497255812225 1.244155491124686 22.361896870667106 -6.974781236512618 0.08667622131946368 0.684295501603392 1.7049679408520395 0.9999998565811988 3.748246392864834e-05 0.0747795054201473 0.0025235522980668248 0.011044324932231023 0.01852975184179623 1.0597874285078647e-07 6.974781236512618 1.0206724392486475 RISVFIQTDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RISVFIQTDK 10 1 Q6YHK3;Q6YHK3-4;Q6YHK3-3 Q6YHK3 CD109 CD109 antigen 0 19148000.0 3553000.0 9938300.0 5656700.0 False True 4599428.5401005605 9385224.868532175 4627238.642643425 1.0 2.0405197703815134 1.006046425615791 22.133023192759556 -6.644795496703715 2.0268907319772405 1.677932277764195 1.0103530870145405 0.17337255396102358 0.4446730909982195 0.5213553620139075 4.099189351606275 0.178285737084374 0.49252130784500897 2.2657109485529509e-07 6.644795496703715 -0.6675791907496544 RIVDGK(ub)VVSETNDTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RIVDGKVVSETNDTK 15 2 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 4846450.0 580810.0 779440.0 3486200.0 True False 562372.504469321 1090674.4567259036 2573059.636241802 1.0 1.9394163975977294 4.575365288653029 19.10116653428919 -6.952943666311279 0.5255349510064441 0.957048723890652 5.676484209594453 0.9994125018856697 0.03668282408950129 0.0823248178356491 0.031233858283663436 0.04120012221287046 0.21785974475535486 1.1144390815779166e-07 6.952943666311279 4.7194354857038014 RIVDGK(ub)VVSETNDTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RIVDGKVVSETNDTK 15 2 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 32274730.0 296230.0 1922500.0 30056000.0 True False 449402.5673138815 1579414.8544389403 24115418.425987218 1.0 3.5144767059948974 53.661060661329074 18.777648840700127 -6.916423037568899 0.8518036058753795 1.803406534028515e-11 61.09278140836583 0.9934591518723425 1.9615326022005406 0.09878201375214066 0.1154090710378188 1.6724291502251023 4.8438069925896565 1.2122074881177362e-07 6.916423037568899 61.0927814083478 up RIVDGK(ub)VVSETNDTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RIVDGKVVSETNDTK 15 2 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 3882410.0 580810.0 1808500.0 1493100.0 True False 482969.2492457015 1798757.2515408562 1805300.3066856076 1.0 3.7243722128275136 3.737919773370903 18.881571809723468 -10.550045567690868 0.9708804899640242 7.88659429358631e-09 3.7343579329175944 0.9999960244632075 0.002567080314914144 2.122860424475921 0.5655403760593043 5.33104690072873 0.0018002201382805074 2.818087232216388e-11 10.550045567690868 3.734357925031 RIVDGK(ub)VVSETNDTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RIVDGKVVSETNDTK 15 2 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 14037530.0 296230.0 3337300.0 10404000.0 True False 383475.57456627866 3151576.32127753 8510578.754054876 1.0 8.218453873736413 22.19327466600858 18.548775162792577 -6.960676103719055 0.4257984994453659 0.41951769103539505 30.52442294801755 0.9997944575439984 0.12612689845795247 0.07946048354221574 0.02024546689701833 0.18154552133575932 1.1615196551833658 1.0947725418741637e-07 6.960676103719055 30.104905256982153 RK(ub)ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RKELEQVCNPIISGLYQGAGGPGPGGFGAQGPK 33 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 72988000.0 21700000.0 37267000.0 14021000.0 True False 28448910.143098924 31706908.865628272 12570241.418928985 1.0 1.1145210381045008 0.4418531801640298 24.761870049212163 -6.8630740768981 1.1701801824898215 1.0627132715521095 0.4073264800021913 0.9572611707285836 0.06074849050486729 0.143668476187208 0.37210227561824377 0.04043794432373412 0.09474049491982826 1.3706479570492495e-07 6.8630740768981 -0.6553867915499182 down RK(ub)ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RKELEQVCNPIISGLYQGAGGPGPGGFGAQGPK 33 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 117116000.0 65671000.0 35389000.0 16056000.0 True False 63586310.05148796 49520012.25119701 11850451.930324806 1.0 0.7787841787186425 0.1863679763887714 25.92221285508626 -7.071898495236259 0.5600417451943756 1.0057887472869302 5.357048035660327e-11 0.999210809709574 0.009649601866678787 0.07507141276972135 0.036093613385404816 0.010428958329793509 0.043976836398155396 8.474254541173864e-08 7.071898495236259 -1.0057887472333598 down RK(ub)ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RKELEQVCNPIISGLYQGAGGPGPGGFGAQGPK 33 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 629860100.0 169441100.0 277257000.0 183162000.0 True False 257054536.50369006 227778322.13117146 146959950.41724348 1.0 0.8861089371511701 0.5717072821048379 27.93749923212324 -6.953304386666146 0.5213077277701762 1.0052890275391162 0.43846517427947723 0.9994357284648213 0.0043024961251195365 0.08218541300752369 0.030676484321867994 0.004864093681441524 0.025973151030505032 1.1135138246954746e-07 6.953304386666146 -0.566823853259639 RK(ub)ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RKELEQVCNPIISGLYQGAGGPGPGGFGAQGPK 33 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 118533000.0 21700000.0 53218000.0 43615000.0 True False 29723076.420450117 50866652.791607894 33314035.27912113 1.0 1.7113522191333648 1.120813835279862 24.825080110735055 -10.227205299243723 4.8584877835034295 0.9999267913463019 1.4160830272073486 0.39828464818942155 0.2410862856640515 0.00019121319024953954 3.0414539430678325e-05 0.2334717052751155 0.07781026411429075 5.926451037644831e-11 10.227205299243723 0.41615623586104666 RK(ub)ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RKELEQVCNPIISGLYQGAGGPGPGGFGAQGPK 33 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 117420000.0 65671000.0 18482000.0 33267000.0 True False 54608346.218581654 18382433.79761024 40222975.89077096 1.0 0.33662315507652607 0.7365719468919613 25.702618130520538 -10.811670480175602 6.965301171167253 1.022604062510288 0.5365975509845544 0.6415736594591435 0.16327841053173886 0.053128733694261056 0.001436505992399332 0.14655035187789087 0.05269788039872022 1.5428706581034915e-11 10.811670480175602 -0.4860065115257335 RK(ub)ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RKELEQVCNPIISGLYQGAGGPGPGGFGAQGPK 33 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 570664100.0 169441100.0 288543000.0 112680000.0 True False 219344844.1334175 272485328.4003182 92173396.19443515 1.0 1.2422691286720091 0.4202213941184333 27.70862555421569 -6.827775936183862 1.3377780591288373 1.1296669286684429 0.3990829448274609 0.9013577647920877 0.1083237845695858 0.1835739407135388 0.6432975669014817 0.06359008660499062 0.14636152414571052 1.486702472920449e-07 6.827775936183862 -0.730583983840982 down RK(ub)ELEQVCNPIISGLYQGAGGPGPGGFGAQGPK(ub)GGSGSGPTIEEVD ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD 46 3 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 2 26198600.0 4992600.0 11090000.0 10116000.0 True False 6463019.118859003 10472831.751106517 8274991.798925325 1.0 1.6204240709341142 1.2803600990099209 22.623776828716952 -10.262648331542433 5.136229423840566 0.9999264856668949 1.4503920849721201 0.7004940466702456 0.13883053518684269 0.00011689202692329915 1.6780608014636284e-05 0.13444392508536443 0.04480736256024551 5.461999656075176e-11 10.262648331542433 0.45046559930522523 RK(ub)EVTEEEAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 RKEVTEEEAER 11 2 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 6645200.0 1627300.0 3392700.0 1625200.0 True False 2133406.058795619 2886522.3846410173 1457039.8940192151 1.0 1.3530112435653991 0.6829641680317362 21.024727154438523 -6.763543830833831 1.5989349605843959 1.204143757341733 0.6800620027095726 0.7053200747527757 0.1485639792666748 0.27701446682203484 1.3965280248134917 0.07328026958906789 0.17550719294570521 1.7236781213703842e-07 6.763543830833831 -0.5240817546321604 RK(ub)EVTEEEAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 RKEVTEEEAER 11 2 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 12520900.0 3816700.0 5306300.0 3397900.0 True False 3695540.947655951 7425133.261988938 2507888.055185017 1.0 2.009214176533109 0.6786254274291693 21.81735412865617 -6.703860765353787 1.8168360664285501 1.6242784490382611 0.6822452340029946 0.43606988814366243 0.4257063714496023 0.3875283678113016 2.489450153961126 0.1867320633093584 0.47799742545993557 1.9776035574402075e-07 6.703860765353787 -0.9420332150352665 RK(ub)EVTEEEAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 RKEVTEEEAER 11 2 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 4618200.0 1057700.0 1126000.0 2434500.0 True False 1604608.2282277031 925056.5025218452 1953320.0079207446 1.0 0.5764999120960349 1.2173189527254233 20.613789669670954 -6.728475151952515 1.7286898805512243 0.7447116037886652 1.216840804746562 0.5522474924479311 0.1780514392690463 0.3390934958991815 1.9844922861851895 0.08164384979409045 0.2029520915236658 1.8686365877608865e-07 6.728475151952515 0.4721292009578968 RK(ub)EVTEEEAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RKEVTEEEAER 11 2 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 5929300.0 1627300.0 2454000.0 1848000.0 True False 2228956.7861289643 2345574.1657072 1411540.4607546902 1.0 1.052319264466659 0.6332740363289486 21.087937215961414 -6.875607005420214 1.103966054294562 1.0308771117247655 0.6059644949465248 0.96996773840846 0.03230895325923481 0.13159450897266425 0.2963838930814475 0.022625896811965748 0.05415602215302679 1.331658895671505e-07 6.875607005420214 -0.42491261677824066 RK(ub)EVTEEEAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RKEVTEEEAER 11 2 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 9675700.0 3816700.0 4496800.0 1362200.0 True False 3173755.158478788 4472574.84585509 1647029.7218988244 1.0 1.4092375191282362 0.5189529877560757 21.597759404090446 -6.781684590622686 1.529025345071927 1.2312068893785053 0.5114866940803413 0.7734248687693146 0.17319275624328034 0.24794992380573022 1.1450463560377098 0.08919945407753196 0.21020370231576 1.6531619827021166e-07 6.781684590622686 -0.719720195298164 RK(ub)EVTEEEAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RKEVTEEEAER 11 2 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 4989600.0 1057700.0 1385200.0 2546700.0 True False 1369213.5003840022 1308112.4023113386 2083226.73134867 1.0 0.9553750397176718 1.5214769141294762 20.384915991763403 -6.887840915531472 1.0350943840909732 0.9679895607406909 1.5681518491531639 0.9794790883478189 0.03681432070651161 0.12091143426964171 0.2322326540820985 0.027173835805583465 0.06723757534811298 1.2946699993761574e-07 6.887840915531472 0.600162288412473 RK(ub)PEDVLDDDDAGSAPLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RKPEDVLDDDDAGSAPLK 18 2 P35613-2;P35613;A0A087WUV8;P35613-3;P35613-4 P35613-2 BSG Basigin 1 43330100.0 3154100.0 13269000.0 26907000.0 True False 4785000.2955970485 10901043.278829798 21588819.65624296 1.0 2.278169823492063 4.511769764383936 22.190087583159066 -6.962595737181618 0.3971603150985839 0.8733037097913325 5.997820302603095 0.9998546886313963 0.017494150580665842 0.07878657165503888 0.017798254598206793 0.028755027555700884 0.18734117964048783 1.0899441953240568e-07 6.962595737181618 5.124516592811763 RK(ub)PEDVLDDDDAGSAPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RKPEDVLDDDDAGSAPLK 18 2 P35613-2;P35613;A0A087WUV8;P35613-3;P35613-4 P35613-2 BSG Basigin 1 34234500.0 3154100.0 7137400.0 23943000.0 True False 4083044.6266060146 6740197.415721152 19585619.675926168 1.0 1.6507773076494308 4.796817440667185 21.961213905251515 -6.9405598406295415 0.6543338169482805 0.9649987013926384 5.659363556422713 0.9982363216968806 0.06962433927413708 0.08751213743909568 0.053453382415366985 0.06806509763712792 0.27011237964742735 1.146674512386832e-07 6.9405598406295415 4.6943648550300745 RK(ub)VDWLTEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RKVDWLTEK 9 2 P38919;I3L3H2;P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3QL43;J3QL52;Q14240-2;Q14240;E7EQG2;J3KTN0 P38919;P60842;Q14240-2;J3KTN0 EIF4A3;EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed;Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 1 33808300.0 3130000.0 4885300.0 25793000.0 True False 4051846.701523997 4613428.760476163 21098938.65852913 1.0 1.138599038986579 5.207240108712235 21.950148161248315 -6.914135713631587 0.8671068598253129 0.8899001694559031 5.782333480621602 0.992390743183295 0.17022829535642678 0.10174596770473528 0.12440604756104984 0.14228350494283115 0.4049823294636586 1.2186087337133974e-07 6.914135713631587 4.892433311165698 up RKEEEVQQQK(ub)LAEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 RKEEEVQQQKLAEER 15 3 Q96CS3 Q96CS3 FAF2 FAS-associated factor 2 1 4207600.0 1095100.0 2010100.0 1102400.0 True False 1435686.7049634857 1710200.9153084324 988334.2229674994 1.0 1.191207600791935 0.6884052206868044 20.453309528437515 -6.803653485737668 1.4410051695827597 1.1050127410726873 0.6808260807534101 0.8426225499099143 0.08220596491410527 0.21557943998907214 0.8833586904681234 0.04487210285281481 0.10412991222358797 1.5716162631575118e-07 6.803653485737668 -0.4241866603192772 RKEEEVQQQK(ub)LAEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RKEEEVQQQKLAEER 15 3 Q96CS3 Q96CS3 FAF2 FAS-associated factor 2 1 3042310.0 1095100.0 680310.0 1266900.0 True False 1499988.0639647436 650251.6547156752 967684.3126245225 1.0 0.43350455269419996 0.6451280085967853 20.516519589960406 -10.149772277012605 5.291560001447855 1.000014600638671 0.5393162806452695 0.8633607574939848 0.08639491409507713 1.4881964109831561e-05 2.3911331564802595e-06 0.0836541645211708 0.027883838623823598 7.08317094197751e-11 10.149772277012605 -0.4606983199934015 RKELEQVCNPIISGLYQGAGGPGPGGFGAQGPK(ub)GGSGSGPTIEEVD ddPTM_RPMI8226_Bortezomib_8h_R1 1 RKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD 46 3 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 98780000.0 14211000.0 37772000.0 46797000.0 True False 21559125.963263564 31031291.486016963 37547552.438146256 1.0 1.439357585223716 1.7416082870022995 24.36179535463843 -7.688687170406417 0.08905759430766264 2.8532738932646575e-16 2.972315578533304 0.9999969329609726 0.0005332037197927912 0.13967462122713226 0.010358758550804398 0.1472662974909395 0.18731424196949129 2.047919256125303e-08 7.688687170406417 2.9723155785333035 RKELEQVCNPIISGLYQGAGGPGPGGFGAQGPK(ub)GGSGSGPTIEEVD ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RKELEQVCNPIISGLYQGAGGPGPGGFGAQGPKGGSGSGPTIEEVD 46 3 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 105624000.0 14211000.0 36840000.0 54573000.0 True False 18396419.64068927 34789821.61503729 44641273.96626649 1.0 1.891119157669628 2.4266283786834673 24.13292167673088 -8.848550827212376 0.1629278242570262 1.8447769194279304e-20 3.24807450636717 0.9998075686747978 0.008162523521917098 0.3625352389371559 0.04993668566718116 0.5363974342817712 0.3562173333230919 1.4172588342921214e-09 8.848550827212376 3.24807450636717 RKPDTIEVQQMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RKPDTIEVQQMK 12 2 P26038;A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-4;P15311;E7EQR4 P26038;A0A2R8Y5S7;P15311 MSN;RDX;EZR Moesin;Radixin;Ezrin 0 16416080.0 3706500.0 440580.0 12269000.0 False True 3588839.1863355283 616505.8915943484 9055380.837889582 1.0 0.17178420642019537 2.5232060752033303 21.775085847653934 -6.811532665017025 1.4081767043157327 0.5494386874921877 2.5657600209222475 0.8637582850091676 0.3594535338886626 0.20472591685675406 0.7998395372626954 0.20070041913533052 0.4639264433570663 1.5433603366834698e-07 6.811532665017025 2.01632133343006 RKPEDVLDDDDAGSAPLK(ub)SSGQHQNDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RKPEDVLDDDDAGSAPLKSSGQHQNDK 27 3 P35613-2;P35613;A0A087WUV8;P35613-3;P35613-4 P35613-2 BSG Basigin 1 9974900.0 4423500.0 3233600.0 2317800.0 True False 5799251.337234935 2751159.484474076 2077976.2899075376 1.0 0.47439907748261523 0.3583180257364583 22.467435234775852 -13.999999999999856 0.21222700303686173 4.06790696138366 0.29140439173458305 0.9994913786982966 0.006296302958771799 12.79975864534761 0.14600064979679425 16.391874873308545 0.06770343939589778 1.0000000000003313e-14 13.999999999999856 -3.7765025696490766 RKPEDVLDDDDAGSAPLK(ub)SSGQHQNDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RKPEDVLDDDDAGSAPLKSSGQHQNDK 27 3 P35613-2;P35613;A0A087WUV8;P35613-3;P35613-4 P35613-2 BSG Basigin 1 10461900.0 4423500.0 1995700.0 4042700.0 True False 6058987.490592677 1907523.3751026334 3087897.522020013 1.0 0.3148254354484636 0.5096391974425354 22.530645296298744 -10.403564293440205 5.270208992255848 1.0004225371319642 0.41223231644560737 0.9238790430857474 0.07953238529296537 0.0003951290853887944 4.471722088743513e-05 0.07706020994918314 0.025668966976976435 3.948532405071528e-11 10.403564293440205 -0.5881902206863567 RKPLSLGITR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RKPLSLGITR 10 2 Q9NX02;A0A0G2JPQ2;A0A0G2JMG8;Q9NX02-5;J3KN39;A0A0G2JLX3;Q9NX02-2;A0A0G2JNC8;Q9NX02-3;A0A0G2JPB6;A0A0G2JP37;F5GYZ4;K7ELX1;K7EPE6;F5H5B1;K7EJ90 Q9NX02 NLRP2 NACHT, LRR and PYD domains-containing protein 2 0 5680800.0 1607800.0 1423400.0 2649600.0 False True 2107841.369957349 1211034.2683697434 2375444.808757884 1.0 0.5745376694994121 1.1269561564805752 21.007334867330076 -6.700967098379941 1.8271720973850383 0.7360623806200227 1.1253575288231379 0.42230473953397274 0.17956045908152227 0.3935023707717592 2.554690194597788 0.07837550203102463 0.20133944150012884 1.990824155683267e-07 6.700967098379941 0.38929514820311517 RKPLSLGITR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RKPLSLGITR 10 2 Q9NX02;A0A0G2JPQ2;A0A0G2JMG8;Q9NX02-5;J3KN39;A0A0G2JLX3;Q9NX02-2;A0A0G2JNC8;Q9NX02-3;A0A0G2JPB6;A0A0G2JP37;F5GYZ4;K7ELX1;K7EPE6;F5H5B1;K7EJ90 Q9NX02 NLRP2 NACHT, LRR and PYD domains-containing protein 2 0 3914850.0 1607800.0 873550.0 1433500.0 False True 2202247.109161278 834953.6725564491 1094936.823859224 1.0 0.3791371409153262 0.4971907191088238 21.070544928852968 -9.976309341425926 5.9840812504110685 1.0000004204956858 0.43816393001311427 0.9679481973545921 0.04819517148097946 2.7037081006430916e-07 4.636447438045627e-08 0.046664808894577185 0.015554924709403591 1.0560650220250923e-10 9.976309341425926 -0.5618364904825716 RKPLSLGITR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RKPLSLGITR 10 2 Q9NX02;A0A0G2JPQ2;A0A0G2JMG8;Q9NX02-5;J3KN39;A0A0G2JLX3;Q9NX02-2;A0A0G2JNC8;Q9NX02-3;A0A0G2JPB6;A0A0G2JP37;F5GYZ4;K7ELX1;K7EPE6;F5H5B1;K7EJ90 Q9NX02 NLRP2 NACHT, LRR and PYD domains-containing protein 2 0 2206800.0 404530.0 1107500.0 694770.0 False True 336384.61871759023 1101533.6776784624 840043.1947464751 1.0 3.274625581508079 2.497269934484515 18.35975221389675 -10.15438858226952 5.615717510465423 0.9999663631893889 2.8859477579964707 0.8869800030432222 0.317354113980414 0.00013365142595048093 2.0126023752912306e-05 0.30728222102860936 0.10242559985795696 7.008279563790133e-11 10.15438858226952 1.8859813948070818 RKTPVIVTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RKTPVIVTLK 10 2 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 14758200.0 4552700.0 3113700.0 7091800.0 False True 5968633.788409513 2649148.097107537 6358008.565349159 1.0 0.44384497206913853 1.0652368348843537 22.50896930780726 -6.67073422109999 1.934576354456682 0.645234791424321 1.0627435066904118 0.2823644894284497 0.23620233846975675 0.45944670305911284 3.315715400242425 0.09826422400115295 0.2623048031741067 2.1343506903568202e-07 6.67073422109999 0.4175087152660908 RKTPVIVTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RKTPVIVTLK 10 2 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 6213080.0 1728200.0 991680.0 3493200.0 False True 1673339.2369688544 1387662.9955428815 2578226.1262463047 1.0 0.8292777488780716 1.5407671494732857 20.67429852269779 -6.843355698804584 1.2666942685001619 0.9091810996379631 1.565770878741222 0.9300770612161908 0.08019536875255798 0.1649135976122518 0.51253952984841 0.04961403138700181 0.11442675314581464 1.4343142104220342e-07 6.843355698804584 0.6565897791032588 RKTPVIVTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RKTPVIVTLK 10 2 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 18171200.0 5564500.0 6785100.0 5821600.0 False True 8441753.319441292 5574245.8927717395 4670958.208302071 1.0 0.6603185004155825 0.5533161218469735 23.00911124154581 -13.999999999999998 0.16169022249408527 2.6789985585917053 0.45006483626324795 0.9995320237827581 0.004119441607948585 12.02139318789803 0.12712712103789106 6.329282209592661 0.094308090285083 1.0000000000000041e-14 13.999999999999998 -2.2289337223284575 RKTPVIVTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RKTPVIVTLK 10 2 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 10800300.0 4552700.0 3861900.0 2385700.0 False True 6235956.222091393 3691268.4884045008 1822246.795033799 1.0 0.5919330343160325 0.29221609808265464 22.57217936933015 -7.9892322088680086 0.2382842697511061 1.191008070191287 2.575642468647376e-09 0.9996841059885778 0.005155670318869367 0.10288847147243776 0.04261960572044984 0.0688560487930589 0.0969104667319859 1.0251036765664694e-08 7.9892322088680086 -1.1910080676156447 down RKTPVIVTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RKTPVIVTLK 10 2 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 25392000.0 5564500.0 10476000.0 9351500.0 False True 7203354.942693373 9893001.390855884 7649622.954492897 1.0 1.3733880212151308 1.0619528005144587 22.78023756363826 -10.272351104585885 5.953932821334679 0.999989874260367 1.2176704108647955 0.39442806960247734 0.1271428964412879 1.7090077303909778e-05 2.0886608313493667e-06 0.12311130504685609 0.04103519337547314 5.3413236645604555e-11 10.272351104585885 0.21768053660442854 RLDLDACK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RLDLDACKAR 10 2 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 1 5256700.0 1073400.0 1761600.0 2421700.0 True False 892579.6596827445 1752109.9111497784 2928066.2733243187 1.0 1.9629731555529086 3.28045372932323 19.76762140492397 -6.966741209253589 0.3267923733846169 0.8333656202872295 4.452985052186576 0.9999446688811449 0.0069530029752796 0.07737497175832912 0.012802685935353624 0.019450026257346802 0.11521559627542574 1.0795898449220518e-07 6.966741209253589 3.6196194318993467 RLDVTVQSFGWSDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RLDVTVQSFGWSDR 14 1 Q8NCA5;E9PH82;Q52LJ0;Q52LJ0-1 Q8NCA5;Q52LJ0 FAM98A;FAM98B Protein FAM98A;Protein FAM98B 0 36805100.0 9022100.0 11754000.0 16029000.0 False True 13687185.30386041 9656406.865578838 12860861.124239715 1.0 0.7055071332200998 0.9396278956355159 23.706322458822754 -9.900416717740887 5.91481611061881 1.0000000556160478 0.8225675151185285 0.4336899833907889 0.09557940101860603 7.006237205862247e-08 1.3056209454317449e-08 0.09254438605554177 0.030848119032067606 1.257718016895707e-10 9.900416717740887 -0.17743254049751922 RLDVTVQSFGWSDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RLDVTVQSFGWSDR 14 1 Q8NCA5;E9PH82;Q52LJ0;Q52LJ0-1 Q8NCA5;Q52LJ0 FAM98A;FAM98B Protein FAM98A;Protein FAM98B 0 36147600.0 9022100.0 8827500.0 18298000.0 False True 11679286.302178785 8336241.865003864 14967951.753334863 1.0 0.7137629517180967 1.281581028674892 23.477448780915203 -6.769636331496839 1.5757067480499174 0.8357487517332765 1.2847424935478695 0.7292368537861483 0.12062386270940421 0.26700761871141765 1.3082583664514895 0.060340871174877034 0.14369242324916076 1.6996663193532315e-07 6.769636331496839 0.44899374181459306 RLEAALVK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 RLEAALVKR 9 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 5481600.0 2043900.0 1867600.0 1570100.0 True False 2679572.6931557544 1588961.3598477822 1407641.1134626935 1.0 0.5929905779030945 0.5253229804356989 21.353571524254797 -13.999999999999998 0.2524671414329154 3.866133041639284 0.4987463692817438 0.9995473801508687 0.004460134805919401 14.097151110220926 0.15899345540536694 20.52086914838592 0.030805682415217084 1.0000000000000041e-14 13.999999999999998 -3.36738667235754 RLEAALVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 RLEAALVKR 9 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 11820500.0 1982900.0 4227300.0 5610300.0 True False 1919953.9248845861 5915282.935078281 4140794.124607699 1.0 3.080950463659624 2.1567153622484008 20.872640258844505 -10.142052116997233 5.255270568049261 0.9999687819678837 2.618832912587297 0.8035561783191513 0.37731740030014627 0.00022180250362571326 3.6211051197499354e-05 0.365347181882409 0.12177866727530441 7.210209487222005e-11 10.142052116997233 1.6188641306194134 RLEAALVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 RLEAALVKR 9 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 6839600.0 1625400.0 2520600.0 2693600.0 True False 2465850.6326570003 2070779.236462313 2161208.7793531776 1.0 0.8397829167093587 0.876455674456013 21.233653981371692 -10.605306306768773 6.462240491668188 1.0003993169725416 0.8581192955826858 0.9522835550437192 0.014971590656667028 8.637262013844993e-05 5.275353745613683e-06 0.01453647051474577 0.004832060106625505 2.4813823754385794e-11 10.605306306768773 -0.14228002138985574 RLEAALVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RLEAALVKR 9 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 5107700.0 2043900.0 1408400.0 1655400.0 True False 2799585.064320644 1346172.2310440175 1264428.6140331791 1.0 0.48084705415825035 0.4516485782652971 21.416781585777688 -13.960956193377609 0.4100401855196909 9.999055958140016 0.4503119246950508 0.9998509235469397 0.003075558484462903 27.35381386030377 0.21209989101843274 219.54844308973176 0.0072735599835225305 1.0940667175486234e-14 13.960956193377609 -9.548744033444965 RLEAALVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RLEAALVKR 9 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 9336800.0 1982900.0 4652200.0 2701700.0 True False 1648869.2073643727 4627137.675210603 3266612.9787505935 1.0 2.8062490672664264 1.981123162565511 20.65304553427878 -10.524034745402455 7.320286432279398 0.9995429666744249 2.393686114915861 0.791835476628033 0.3368562400115972 0.002513356203127744 0.0001634181969308445 0.32624717289687893 0.10871988396924705 2.992025252308883e-11 10.524034745402455 1.3941431482414361 RLEAALVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RLEAALVKR 9 2 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 4710500.0 1625400.0 3085100.0 0.0 True False 2104112.3414239935 2913411.4729791437 0.0 1.0 1.3846273393403716 0.0 21.00478030346414 -6.861272511837753 1.3807581064623293 1.202913750614347 1.406060873825639e-20 0.9100365216281217 0.17503963089725458 0.16431010000730625 0.6297917206248245 0.10226004624991443 0.21304675662675865 1.3763455662315558e-07 6.861272511837753 -1.202913750614347 down RLEAALVK(ub)RPNPDILDHER ddPTM_RPMI8226_Bortezomib_8h_R1 1 RLEAALVKRPNPDILDHER 19 3 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 44662600.0 7788600.0 16845000.0 20029000.0 True False 11815875.622931167 13838878.139414294 16070259.370977443 1.0 1.1712105459672466 1.3600565784383984 23.494223209312725 -6.969863335404054 0.2614287850034495 0.9478976933395522 1.5889826903167905 0.9999812959700617 0.0006359433057885505 0.07634706370029401 0.009188649071655786 0.0039061248612091404 0.01778001587226104 1.0718565459860577e-07 6.969863335404054 0.6410849969772383 RLEAALVK(ub)RPNPDILDHER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RLEAALVKRPNPDILDHER 19 3 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 8377300.0 1470300.0 3124700.0 3782300.0 True False 2013909.6433634916 2986640.4219988952 2888998.6389136687 1.0 1.4830061675511998 1.4345224714693081 20.9415675257594 -10.145564818685012 4.989015434807266 0.9999749508188016 1.45876431951132 0.9916928764792581 0.019793386044502464 5.515187218743916e-06 9.445305432390695e-07 0.019165908414409485 0.006388287875755067 7.152126402377654e-11 10.145564818685012 0.4587893686925184 RLEAALVK(ub)RPNPDILDHER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RLEAALVKRPNPDILDHER 19 3 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 17660800.0 6747500.0 7159000.0 3754300.0 True False 5610845.214933222 7120433.04604976 4539306.772078082 1.0 1.2690482045554885 0.8090237028811187 22.41978668339248 -6.748164814552499 1.6564858974244447 1.1585489103665796 0.8082270209346691 0.6411112193966718 0.11304727992204198 0.30325049878232946 1.636558642094057 0.05392249974724354 0.13117022578798157 1.7858097322826223e-07 6.748164814552499 -0.35032188943191045 RLEAALVK(ub)RPNPDILDHER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RLEAALVKRPNPDILDHER 19 3 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 1 40116600.0 7788600.0 22234000.0 10094000.0 True False 10082496.236258717 20996658.354743198 8256995.573186257 1.0 2.082486108870036 0.8189435810045148 23.265349531405175 -6.679887088638381 1.9021134332897565 1.6849624502018494 0.8237362036148941 0.3236862813503756 0.4587931688885799 0.43877289514089013 3.0691233898484107 0.1935419155683331 0.5105604095819392 2.0898393934321312e-07 6.679887088638381 -0.8612262465869553 RLEAAYLDLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RLEAAYLDLQR 11 1 E5RJD8;O75347;E5RIW3;E5RHG6;O75347-2 E5RJD8 TBCA Tubulin-specific chaperone A 0 16717700.0 5043600.0 5461800.0 6212300.0 False True 6908355.218165078 5220479.616242694 4745082.686334609 1.0 0.755676199526593 0.6868614216387886 22.71991083550162 -13.999999998167455 0.1777385168398276 2.2590716095241947 0.6309027936735564 0.9995010388338532 0.0030013623952831066 12.176327968350504 0.13362455906612652 5.291863557842864 0.05238444046451921 1.0000000042195903e-14 13.999999998167455 -1.6281688158506382 RLEAFLTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RLEAFLTQK 9 1 Q02750;Q02750-2;P36507;A0A1B0GUL7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 0 29287700.0 8060300.0 5717400.0 15510000.0 False True 10567131.356056243 4864386.206250654 13905173.982425556 1.0 0.46033176293041655 1.3158891958370718 23.33308044773555 -6.736240738621784 1.7006900553655364 0.6775053758246433 1.3159685487463324 0.5878574991991548 0.22677414836896456 0.32465681782859945 1.8422981865319445 0.10555706950782145 0.2600811190849618 1.8355205933863525e-07 6.736240738621784 0.6384631729216891 RLEAFLTQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RLEAFLTQK 9 1 Q02750;Q02750-2;P36507;A0A1B0GUL7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 0 18646400.0 6172400.0 2022000.0 10452000.0 False True 5976460.540600942 2829395.144590698 7714307.646721156 1.0 0.4734232118440789 1.2907819928391044 22.510859894499628 -6.732769731953972 1.713364517434051 0.6840881140201941 1.2905264551478184 0.5719783306602624 0.22131549501477238 0.33105906808875735 1.9052367624451987 0.10231575385456791 0.2530747531907639 1.8502493829494022e-07 6.732769731953972 0.6064383411276243 RLEAFLTQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RLEAFLTQK 9 1 Q02750;Q02750-2;P36507;A0A1B0GUL7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 0 22051800.0 4082600.0 13596000.0 4373200.0 False True 6193602.678039549 11169687.573967153 3508835.103158345 1.0 1.8034233312335555 0.566525701688858 22.56234740587121 -6.7313910272583755 1.7180811882242115 1.4827543868885313 0.5670686473945666 0.5656886830911028 0.33770631610957486 0.33366121231961476 1.9301257519619555 0.1557228456172823 0.38581997547144686 1.856132489934646e-07 6.7313910272583755 -0.9156857394939647 RLEAFLTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RLEAFLTQK 9 1 Q02750;Q02750-2;P36507;A0A1B0GUL7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 0 27273700.0 8060300.0 7614400.0 11599000.0 False True 11040410.73141725 7277970.630546406 8859555.088903498 1.0 0.659211944881342 0.8024660770719535 23.396290509258442 -10.127688407199113 5.169132426187804 1.0000083352373732 0.7308390115777039 0.824778070533661 0.05848325456980458 81642002.13031562 5.964808349361626 8099.613162271976 0.02002037360245591 7.452664876902952e-11 10.127688407199113 -0.2691693236596693 RLEAFLTQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RLEAFLTQK 9 1 Q02750;Q02750-2;P36507;A0A1B0GUL7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 0 13381400.0 6172400.0 4207400.0 3001600.0 False True 5132624.083683416 4184733.9010964893 3629220.6821696665 1.0 0.8153205519959538 0.7070887372614992 22.291265169933904 -13.999999999962538 0.05798925711750072 2.202129249712699 0.19443919602730866 0.9999591720794428 0.0007726846588732112 12.484802797922882 0.06079316471979996 2.2185854115184673 0.4824848915128918 1.0000000000862585e-14 13.999999999962538 -2.0076900536853906 RLEAFLTQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RLEAFLTQK 9 1 Q02750;Q02750-2;P36507;A0A1B0GUL7 Q02750;P36507 MAP2K1;MAP2K2 Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2 0 21910800.0 4082600.0 14919000.0 2909200.0 False True 5285006.180077277 14088744.53514499 2379755.4509127676 1.0 2.6657952810452503 0.450284326985966 22.33347372796366 -6.705486327025612 1.8108409762533406 2.028751772074793 0.45604867985470726 0.4438474395907962 0.7024705682799268 0.38422363934497755 2.452976705502732 0.3090120919053467 0.7894963074770286 1.9702152348950134e-07 6.705486327025612 -1.572703092220086 RLELYFRPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RLELYFRPK 9 2 Q9Y5Q8;Q9Y5Q8-3;Q5T7U1;Q5T7U4 Q9Y5Q8 GTF3C5 General transcription factor 3C polypeptide 5 0 10865700.0 4882800.0 4061500.0 1921400.0 False True 6401398.085102458 3455540.0316029983 1722591.959370241 1.0 0.5398102079676694 0.2690962093701239 22.609955597900463 -8.748603737175143 0.21128962478460858 1.3337396408448285 8.59380574010389e-23 0.9995715488453408 0.00624519031262973 0.2911822428659101 0.06195606628668312 0.19474883040243504 0.12828614773546196 1.7840058034633248e-09 8.748603737175143 -1.3337396408448285 down RLELYFRPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RLELYFRPK 9 2 Q9Y5Q8;Q9Y5Q8-3;Q5T7U1;Q5T7U4 Q9Y5Q8 GTF3C5 General transcription factor 3C polypeptide 5 0 16032700.0 4882800.0 4598700.0 6551200.0 False True 6688103.112708468 4395514.228132719 5003941.486199199 1.0 0.657213884723239 0.7481854573520118 22.673165659423354 -9.980042519037982 6.750847161390343 1.0000000386917454 0.7026996710376248 0.9343843472169251 0.037138989006510845 2.1610729574019263e-08 3.2940164181521583e-09 0.03595967603393134 0.011986557159765631 1.0470260353067729e-10 9.980042519037982 -0.2973003676541206 RLELYFRPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RLELYFRPK 9 2 Q9Y5Q8;Q9Y5Q8-3;Q5T7U1;Q5T7U4 Q9Y5Q8 GTF3C5 General transcription factor 3C polypeptide 5 0 5818700.0 2728200.0 1248200.0 1842300.0 False True 2268619.1797526255 1241475.6988516992 2227516.412167235 1.0 0.5472384743688327 0.9818820329334108 21.113383021616603 -10.712828064182775 9.898255189103706 1.0003383597359226 0.7645602536511217 0.2812114284436138 0.17744248974511895 0.0013267678902349415 3.849264668670115e-05 0.1720446433200539 0.05726931730770217 1.937188739073727e-11 10.712828064182775 -0.23577810608480088 RLELYFRPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RLELYFRPK 9 2 Q9Y5Q8;Q9Y5Q8-3;Q5T7U1;Q5T7U4 Q9Y5Q8 GTF3C5 General transcription factor 3C polypeptide 5 0 27822200.0 5386200.0 11652000.0 10784000.0 False True 6972542.077874931 11003555.957068818 8821422.653184135 1.0 1.5781268630826888 1.265165925807177 22.733253304975513 -10.14028203554435 4.565206999175583 0.9999503578060566 1.4216463944525584 0.707621339804678 0.12776576765419576 89290720.96966219 4.441637713723702 47058.788678933015 0.04373762063381801 7.239656562362815e-11 10.14028203554435 0.4216960366465018 RLGVLYWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RLGVLYWK 8 1 Q9BV57 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 0 9304500.0 4485800.0 1856500.0 2962200.0 False True 5880927.240548992 1579517.4365803222 2655699.9594288184 1.0 0.26858306045508434 0.45157844176642215 22.48761221075949 -10.806880082638425 10.650101950532596 1.0056153698445844 0.3600807511216449 0.9422117314484714 0.0747075515831364 0.00986129843151685 0.00017881610763290776 0.07161194016633786 0.024111758593118243 1.5599831858108853e-11 10.806880082638425 -0.6455346187229396 RLGVLYWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RLGVLYWK 8 1 Q9BV57 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 0 9574700.0 4485800.0 3119400.0 1969500.0 False True 6144321.484186871 2981574.5935236486 1504344.6631257362 1.0 0.4852569321441072 0.24483495321612694 22.55082227228238 -10.017977230284886 0.18491088293729355 1.6576013634734796 1.6495743557033945e-11 0.9995248621366315 0.006866307297345044 1.548426718183977 0.08503329969969672 0.6625800728473906 0.15772071694113401 9.594509334484814e-11 10.017977230284886 -1.657601363456984 RLGVLYWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RLGVLYWK 8 1 Q9BV57 Q9BV57 ADI1 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase 0 26785000.0 3775000.0 11617000.0 11393000.0 False True 4886811.916374779 10970503.737836272 9319590.90205182 1.0 2.244920395048599 1.9070901564317708 22.220462148528135 -10.107366848291255 4.687743178819839 0.9999315897075038 2.0760052757542797 0.931158088133776 0.13791861744502593 48036649.97932336 5.143691533284215 36486.41749915675 0.04721321116214623 7.809678428193276e-11 10.107366848291255 1.076073686046776 RLLSVNIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RLLSVNIR 8 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 21673100.0 9714600.0 3048800.0 8909700.0 False True 12735934.676320212 2593930.9241293203 7987809.711877294 1.0 0.20367024408127568 0.6271867683750721 23.602401505520547 -10.235203343234158 5.329690947977381 1.0000490577713705 0.41542850625505184 0.717532589971946 0.17289989702643116 0.00010079588528936807 1.446350169083582e-05 0.16742359363181591 0.055803201811986634 5.8183073205065024e-11 10.235203343234158 -0.5846205515163188 RLLSVNIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RLLSVNIR 8 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 115705000.0 22564000.0 40494000.0 52647000.0 False True 34231237.649361745 33267529.3189339 42241297.374000154 1.0 0.9718471081793967 1.2339985426962137 25.028810118940747 -6.880323574076748 1.0780276858314857 0.9824771503055535 1.2526901388472662 0.9739440011246717 0.018967844092226196 0.12734224600419355 0.27057635408669123 0.013550153180911408 0.03279388018341631 1.3172749281467905e-07 6.880323574076748 0.2702129885417127 RLLSVNIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RLLSVNIR 8 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 29174600.0 9714600.0 13499000.0 5961000.0 False True 13306350.147193758 12902569.544776486 4553134.570648654 1.0 0.969655044550107 0.34217757088023776 23.665611567043438 -6.916972587464277 0.8468822829639874 1.015412580203024 0.24771848287344042 0.9932976230238192 0.024822495690917146 0.09998612237870869 0.11508869294782315 0.021051038759613006 0.061342485296321886 1.210674548548413e-07 6.916972587464277 -0.7676940973295836 down RLLSVNIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RLLSVNIR 8 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 115858000.0 22564000.0 43174000.0 50120000.0 False True 29209542.802935276 40771328.94700383 40998674.27462806 1.0 1.3958222222809562 1.403605477539624 24.799936441033196 -11.642215418835756 0.6153027614231975 1.6160804474560722e-10 1.4025788029721595 0.999964247775622 0.0011268095381511394 5.437853047617018 0.3075627363602208 7.253583792952235 0.0013286104066350455 2.2792112567466744e-12 11.642215418835756 1.4025788028105515 RLNPDGK(ub)SIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RLNPDGKSIR 10 2 P25685;M0R080;P25685-2;M0QXK0;M0QYT3;M0QZD0 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 2029760.0 458190.0 515770.0 1055800.0 True False 443645.00925052585 721719.6507050176 779254.306678933 1.0 1.6267953784136076 1.7564816247913406 18.7590462135354 -11.344653702127028 0.2810567247934118 1.1287842657238643e-10 1.8012172983698878 0.9993055649979271 0.00870442998726137 3.585529359949975 0.1506386787783424 2.2648364797516884 0.050870254940164075 4.522163890991274e-12 11.344653702127028 1.8012172982570094 RLNPDGK(ub)SIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RLNPDGKSIR 10 2 P25685;M0R080;P25685-2;M0QXK0;M0QYT3;M0QZD0 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 7979940.0 799440.0 1191100.0 5989400.0 True False 1212808.92689265 978538.8988932243 4805592.464752725 1.0 0.8068368208670336 3.9623656770610864 20.209920846956667 -6.892333394154859 1.008459392633974 0.8398123382966387 4.246529035398811 0.9823508561163286 0.19185627043206868 0.11727102028241619 0.21094375346141647 0.14449409665949958 0.3633941863104228 1.2813465557266883e-07 6.892333394154859 3.406716697102172 up RLNPDGK(ub)SIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RLNPDGKSIR 10 2 P25685;M0R080;P25685-2;M0QXK0;M0QYT3;M0QZD0 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 4446340.0 799440.0 1343100.0 2303800.0 True False 1034890.8393183205 1268355.3043202113 1884532.0389841998 1.0 1.225593324563268 1.820995961492456 19.981047169049116 -6.954289816543736 0.509579783391598 0.9890041298151976 2.083687569257113 0.9994963396338942 0.007772217768203873 0.08180757804297133 0.029177361294739218 0.008958579644698908 0.04913862464434507 1.1109900858878873e-07 6.954289816543736 1.0946834394419152 RLNVWDLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RLNVWDLSK 9 1 Q09028-3;Q09028;Q09028-2;Q09028-4;H0YF10;H0YCT5;Q16576;E9PC52;Q16576-2;Q5JP02;H0YDK2;H0YEU5 Q09028-3;Q16576;H0YDK2 RBBP4;RBBP7 Histone-binding protein RBBP4;Histone-binding protein RBBP7 0 8620600.0 1773000.0 3001200.0 3846400.0 False True 2324420.1697564223 2553432.658585975 3448411.4252741258 1.0 1.0985245661732281 1.4835576932872199 21.148439447891647 -6.945410252984333 0.6071544795089587 0.9957224091122842 1.6063131976822105 0.9987900170680745 0.007257590968369912 0.08538294872679227 0.044006562235593266 0.007397188735407539 0.03243478880163566 1.1339391425780875e-07 6.945410252984333 0.6105907885699263 RLNVWDLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RLNVWDLSK 9 1 Q09028-3;Q09028;Q09028-2;Q09028-4;H0YF10;H0YCT5;Q16576;E9PC52;Q16576-2;Q5JP02;H0YDK2;H0YEU5 Q09028-3;Q16576;H0YDK2 RBBP4;RBBP7 Histone-binding protein RBBP4;Histone-binding protein RBBP7 0 6444820.0 3880800.0 1746600.0 817420.0 False True 3227057.148590273 1737190.7191270462 988338.7426769477 1.0 0.5383204074603795 0.30626626587902217 21.621787696345724 -10.066847803219714 0.15973513614337617 1.7088567404807973 1.945552610658741e-12 0.999677180808277 0.005180664602526576 1.6393328030772032 0.07479693039445803 0.6717236891873202 0.18573869872044274 8.573382433808045e-11 10.066847803219714 -1.7088567404788517 RLNVWDLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RLNVWDLSK 9 1 Q09028-3;Q09028;Q09028-2;Q09028-4;H0YF10;H0YCT5;Q16576;E9PC52;Q16576-2;Q5JP02;H0YDK2;H0YEU5 Q09028-3;Q16576;H0YDK2 RBBP4;RBBP7 Histone-binding protein RBBP4;Histone-binding protein RBBP7 0 27738400.0 7828900.0 9408500.0 10501000.0 False True 10134665.380690474 8884908.704263814 8589925.749358913 1.0 0.876684959050763 0.847578625114279 23.27279511990456 -13.999999999999998 0.20282355351879636 1.6929788654442806 0.8291929690914561 0.9994872613778141 0.0014960383650607734 12.588130151938646 0.14278840294939174 3.4647981300195654 0.01815062953228329 1.0000000000000041e-14 13.999999999999998 -0.8637858963528244 RLPFGK(ub)CR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RLPFGKCR 8 2 A0A087WZ50;A0A087WT77;Q8TCT7-2;Q8TCT7-4;Q8TCT7 A0A087WZ50 SPPL2B Signal peptide peptidase-like 2B 1 3677330.0 182050.0 992380.0 2502900.0 True False 235667.31374199482 937153.1806278693 2047397.8819227135 1.0 3.9765938082268426 8.687661642225766 17.846392149985487 -6.964349905737562 0.3690390190457528 0.6337455246112934 12.19424796592212 0.9998991116365346 0.03179016413632653 0.07818224726441761 0.01564199230815659 0.062187600744805165 0.4003155983346951 1.085550656339375e-07 6.964349905737562 11.560502441310826 RLPNNHIGISFIPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RLPNNHIGISFIPR 14 1 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 42592700.0 17422200.0 11795500.0 13375000.0 False True 22840672.91682482 10035657.378498893 11991083.302059425 1.0 0.43937660746879575 0.5249881798896824 24.445101819267162 -10.745553787328756 6.97950797675127 1.0086749592181727 0.48218239367923904 0.979910958693073 0.03495077808475017 0.004705456800623324 0.00017154277244982487 0.033751517760927705 0.011280315121602377 1.7965785603167204e-11 10.745553787328756 -0.5264925655389336 RLPNNHIGISFIPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RLPNNHIGISFIPR 14 1 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 40542400.0 11551000.0 4699200.0 24292200.0 False True 11184319.827697719 6575615.0660042595 17929344.069621116 1.0 0.587931601322764 1.603078626669768 23.41497418604933 -6.796501297438377 1.4700857781308878 0.7716235089851874 1.6159220096926206 0.8217527577813333 0.17599988009693293 0.22579139596895914 0.9636834795974067 0.09419919171313923 0.21956263932965944 1.5977127559449397e-07 6.796501297438377 0.8442985007074332 RLPNNHIGISFIPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RLPNNHIGISFIPR 14 1 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 38040700.0 14252200.0 9415300.0 14373200.0 False True 21621629.375387054 7735066.152925331 11532330.720002646 1.0 0.35774668128066844 0.5333701045273884 24.365971910837107 -10.78788934215717 10.682281982210242 1.0030062836519595 0.4455583929046972 0.9300150747181667 0.07169796230588489 0.005133138627723151 0.00010192495964726001 0.06941805972600762 0.023140417830641587 1.629711228694914e-11 10.78788934215717 -0.5574478907472624 RLPNNHIGISFIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RLPNNHIGISFIPR 14 1 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 37297800.0 17422200.0 7355600.0 12520000.0 False True 23863658.15725192 7030605.270283563 9563033.857493902 1.0 0.2946155708380793 0.40073629091052804 24.508311880790053 -10.54578958094454 6.674806565886965 1.0006063127706484 0.34767593087430365 0.9805374814069718 0.04332360255237134 0.0003912257996251999 2.662229958075075e-05 0.04198322684240333 0.013982632598586939 2.8458396049048814e-11 10.54578958094454 -0.6529303818963448 RLPNNHIGISFIPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RLPNNHIGISFIPR 14 1 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 24716400.0 11551000.0 6627500.0 6537900.0 False True 9605168.296064263 6591796.342044256 7904944.662165863 1.0 0.6862759858924343 0.8229886680283292 23.195379461483608 -10.127185832047875 4.810914457126506 1.0000155161141233 0.7546323269586834 0.811139992904403 0.05581271877255726 9.289066379595051e-06 1.685257498336952e-06 0.054043847841782996 0.01801347752522451 7.461294257131353e-11 10.127185832047875 -0.24538318915543988 RLPNNHIGISFIPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RLPNNHIGISFIPR 14 1 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 54946800.0 14252200.0 25945600.0 14749000.0 False True 18449753.852862712 24501704.551984623 12064833.337519735 1.0 1.3280233843435736 0.6539292303700693 24.137098232929556 -6.774400265262794 1.5576850423187416 1.1870905321558722 0.649499230075733 0.7470490515269985 0.1384251387990701 0.2593898318212599 1.2426658300776894 0.07002264357915854 0.16601426757744647 1.6811239476626893e-07 6.774400265262794 -0.5375913020801393 RLPPFETFSQGPTLQFTLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RLPPFETFSQGPTLQFTLR 19 1 J3QQW9;Q15022 J3QQW9 SUZ12 Polycomb protein SUZ12 0 25593400.0 6639600.0 8010800.0 10943000.0 False True 10072758.619779384 6581210.15133392 8780111.253512716 1.0 0.6533672055250802 0.8716689821467221 23.2639555116125 -10.429926574844062 5.9367929672196365 1.0000979992213195 0.7625180938359011 0.6120905128038835 0.08912132711100974 0.00011564751859321297 1.110497104042821e-05 0.08632680810268169 0.028763784641070295 3.715980490027559e-11 10.429926574844062 -0.2375799053854184 RLSELLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RLSELLR 7 1 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 13494700.0 3024900.0 5040900.0 5428900.0 False True 3915792.6796932654 4760369.483692772 4440895.905218044 1.0 1.2156847599157534 1.1340988322103691 21.900872953291284 -10.164347795596361 4.370333545956606 0.9999615580558344 1.1748917960689882 0.8596882878404479 0.0333073155378311 23332481.690315075 0.7836830967550035 9149.151037270365 0.011401980027362544 6.849394873845958e-11 10.164347795596361 0.17493023801315377 RLSFLVSYIASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RLSFLVSYIASK 12 1 P47897;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9;A0A0U1RQU2;A0A0U1RQL2 P47897 QARS Glutamine--tRNA ligase 0 36426000.0 0.0 13686000.0 22740000.0 False True 0.0 11243626.370793927 18245429.032703932 0.0 RLSFLVSYIASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RLSFLVSYIASK 12 1 P47897;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9;A0A0U1RQU2;A0A0U1RQL2 P47897 QARS Glutamine--tRNA ligase 0 33928000.0 0.0 17892000.0 16036000.0 False True 0.0 16896294.47166795 13117612.543254877 0.0 RLSLMLHGLVTPSLP ddPTM_RPMI8226_Bortezomib_8h_R1 1 RLSLMLHGLVTPSLP 15 1 Q6P2E9;Q6P2E9-2;I3L0V0;I3L2F4 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 0 22808000.0 0.0 10102000.0 12706000.0 False True 0.0 8299219.172713755 10194653.530762356 0.0 RLSLMLHGLVTPSLP ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RLSLMLHGLVTPSLP 15 1 Q6P2E9;Q6P2E9-2;I3L0V0;I3L2F4 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 0 10340600.0 0.0 5483400.0 4857200.0 False True 0.0 5178243.969704003 3973239.439080677 0.0 RLTGPGLSEGPEPSISVMVTGGPWPTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RLTGPGLSEGPEPSISVMVTGGPWPTR 27 1 Q8WU39;Q8WU39-3 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 87517000.0 20040000.0 32556000.0 34921000.0 False True 30402145.120245058 26746127.438811038 28018849.04358196 1.0 0.8797447460705842 0.9216076343548522 24.857669785418455 -10.123273698215721 6.581540892957131 1.0000001685943383 0.9006761907688824 0.882430788921294 0.0170904525759325 4.227313219755348e-08 5.638579476289228e-09 0.016547787661584157 0.005515919850477789 7.528809385120621e-11 10.123273698215721 -0.09932397782545588 RLTGPGLSEGPEPSISVMVTGGPWPTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RLTGPGLSEGPEPSISVMVTGGPWPTR 27 1 Q8WU39;Q8WU39-3 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 55062000.0 20040000.0 16637000.0 18385000.0 False True 25942175.04745715 15711136.324901624 15039118.64603026 1.0 0.6056213982120064 0.5797169519717813 24.628796107510905 -13.999999999999998 0.3869757297006759 7.11642852228698 0.5777137477431054 0.9998185200262971 0.0025906692550092367 24.94105947900803 0.2035832683938365 127.44706564741946 0.006877772631524567 1.0000000000000041e-14 13.999999999999998 -6.538714774543875 RLVMSIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RLVMSIR 7 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 0 3890600.0 1383800.0 1101200.0 1405600.0 False True 1814175.2007382633 936905.2524439814 1260161.9954672684 1.0 0.5164359275017736 0.6946197891771733 20.790882357622184 -10.048583566757737 5.005134645143155 1.0000068241566247 0.6055278583368829 0.8672831055621995 0.0727432569262162 123047508618.55038 23388087067.655136 10026917.723114848 0.024907965999153438 8.941624610213572e-11 10.048583566757737 -0.39447896581974173 RLVMSIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RLVMSIR 7 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 0 16035600.0 3284600.0 3229000.0 9522000.0 False True 4982978.336424999 2652759.721707848 7639972.526359141 1.0 0.5323642895086417 1.533214076110229 22.24857687122036 -6.779639762178055 1.5371417028747187 0.7350885137716873 1.5410713452693123 0.7661518179643363 0.19772919862927746 0.2511372676785801 1.172013175968863 0.10131483440115933 0.2391457904538363 1.660964069746704e-07 6.779639762178055 0.8059828314976251 RLVMSIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RLVMSIR 7 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 0 3293920.0 1383800.0 1191400.0 718720.0 False True 1895428.2557888892 1138760.008567056 548973.1385030367 1.0 0.6007929897051666 0.2896301333624208 20.854092419145076 -7.848892001456568 0.2510055573706528 1.1611333006409204 1.1323232482470598e-09 0.9996890385673995 0.00512709017282429 0.11768516774403188 0.039531059186671554 0.05281555826879941 0.08846677602120796 1.4161458974388977e-08 7.848892001456568 -1.161133299508597 down RLVMSIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RLVMSIR 7 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 0 25149600.0 3284600.0 11594000.0 10271000.0 False True 4251979.449145599 10948783.708054896 8401783.389359629 1.0 2.5749850955312037 1.9759698958676526 22.01970319331281 -9.859473770770675 5.826372114630654 0.9999997112898806 2.27547749570158 0.8580588210291764 0.2445469312321459 9.168399935932505e-07 1.798566066771614e-07 0.23678160092484135 0.07892718266790513 1.3820578728108444e-10 9.859473770770675 1.2754777844116996 RLYIMTLGCLAPYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RLYIMTLGCLAPYR 14 1 E7EQ69;Q9GZZ1 E7EQ69 NAA50 N-alpha-acetyltransferase 50 0 19844400.0 2933300.0 8246900.0 8664200.0 False True 3797214.6739873276 7787952.765392273 7087404.502199367 1.0 2.050964571148253 1.8664745374422356 21.85651013276422 -10.224065730404487 4.726672739615844 0.9997938875500474 1.9587195542987492 0.972977428110613 0.07531774088013249 0.00016362502539971817 2.6860921217092515e-05 0.07294139104428891 0.02430869634018812 5.96944932220782e-11 10.224065730404487 0.9589256667487018 RMEELHNQEVQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RMEELHNQEVQKR 13 2 Q15233;Q15233-2;H7C367;C9JYS8 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 8871720.0 203020.0 1093800.0 7574900.0 True False 262813.39212249225 1032929.0684725255 6196345.925037505 1.0 3.9302756230591824 23.576979373065996 18.003679267054576 -6.93353300311118 0.7172005480232908 0.7368305894709529 27.998924937619794 0.997188173639999 0.5315316566234008 0.09084442186405009 0.0689947924621756 0.49486168609093456 1.744442981858432 1.1653784874802888e-07 6.93353300311118 27.262094348148842 RNDFQLIGIQDGYLSLLQDSGEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RNDFQLIGIQDGYLSLLQDSGEVR 24 1 I3L397;I3L504;P63241;P63241-2 I3L397 EIF5A Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1 0 463498700.0 65187000.0 248121700.0 150190000.0 False True 98893444.80805467 203842444.0513096 120504880.66938445 1.0 2.061233122649875 1.2185325418006834 26.559371558741525 -10.166518844892147 4.519966384172635 0.9998967057837899 1.6398828322373793 0.43463346642157485 0.3440310715644311 241052546.19041678 57.396346356323775 274316.99431249016 0.11777098647746562 6.815240014176051e-11 10.166518844892147 0.6399861264535894 RNDFQLIGIQDGYLSLLQDSGEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RNDFQLIGIQDGYLSLLQDSGEVR 24 1 I3L397;I3L504;P63241;P63241-2 I3L397 EIF5A Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1 0 33454100.0 28146000.0 5308100.0 0.0 False True 23404646.079216115 5279504.21172465 0.0 1.0 0.22557505009285211 0.0 24.480291613255407 -9.246900580502205 0.46021728859658534 1.1556090943093467 9.974617503215289e-25 0.9970847334533844 0.023122839712431842 0.6982058958879673 0.2045343708303828 0.2521893586535833 0.049859312969276245 5.663689284239459e-10 9.246900580502205 -1.1556090943093467 RNDFQLIGIQDGYLSLLQDSGEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RNDFQLIGIQDGYLSLLQDSGEVR 24 1 I3L397;I3L504;P63241;P63241-2 I3L397 EIF5A Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1 0 161951000.0 65187000.0 51571000.0 45193000.0 False True 84385856.52787375 48701028.51544758 36968337.71933886 1.0 0.577123116589579 0.4380868932358082 26.330497880833974 -13.999999999999998 0.15549221419199719 3.0640099413250885 0.2943738767481962 0.9995489553063448 0.005074912061000302 11.982648044242994 0.12444461425884713 7.463176866377807 0.13028058175490634 1.0000000000000041e-14 13.999999999999998 -2.7696360645768925 RNEFLGELQK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RNEFLGELQKK 11 2 D6RDU5;D6RGI3;D6RER5;Q9NVA2;Q9NVA2-2;H0Y961;Q14141;B1AMS2;Q14141-2;Q14141-4 D6RDU5;Q14141 SEPT11;SEPT6 Septin-11;Septin-6 1 42227000.0 13737000.0 17500000.0 10990000.0 True False 17782817.296752438 16526109.616263669 8989932.766922627 1.0 0.9293302259412926 0.505540411111596 24.083980569823037 -6.935845913749293 0.6971343521930379 1.0052663356414007 0.4039908935858728 0.9975676541278446 0.010768659692914531 0.08971379452037508 0.063628085201878 0.010177880296569375 0.03719084320223956 1.1591885594841393e-07 6.935845913749293 -0.6012754420555279 RNEFLGELQKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 RNEFLGELQKK 11 2 D6RDU5;D6RGI3;D6RER5;Q9NVA2;Q9NVA2-2;H0Y961;Q14141;B1AMS2;Q14141-2;Q14141-4 D6RDU5;Q14141 SEPT11;SEPT6 Septin-11;Septin-6 1 14931300.0 4645600.0 3055100.0 7230600.0 True False 4498127.97087287 4275017.362136028 5336688.946649639 1.0 0.9503992304839769 1.1864244372785253 22.100893275419317 -6.851819729064671 1.226211410405762 0.9734833791255548 1.1961997443501506 0.9429200681893622 0.02427617227901804 0.15546668253376372 0.44890576834908497 0.01548377494701682 0.03587598710893239 1.406631280374486e-07 6.851819729064671 0.2227163652245958 RNEWGYACSLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RNEWGYACSLKR 12 2 Q53HC5 Q53HC5 KLHL26 Kelch-like protein 26 1 11437000.0 3184000.0 2104400.0 6148600.0 True False 4121750.7660231274 1987288.2900837276 5029617.889963645 1.0 0.4821466417779461 1.220262498990562 21.97482583997198 -6.71814313891254 1.7661613063996988 0.6843195745799252 1.2189812074623905 0.5036804148819376 0.2179655060406817 0.3589304006836787 2.1871206548772033 0.09803316997814146 0.2466237380898971 1.9136251102783302e-07 6.71814313891254 0.5346616328824653 RNK(ub)TPVQDCPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RNKTPVQDCPR 11 2 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4 A3QJZ7 LOC101929983;PRAMEF25;PRAMEF6 PRAME family member 6 1 2478080.0 528080.0 770500.0 1179500.0 True False 692317.9939339937 655544.4033854761 1057456.6545629243 1.0 0.946883381811937 1.5274146618002582 19.401075319950934 -6.8845343607818466 1.0541534558064078 0.9645993976848334 1.572314002013799 0.9771640050855099 0.03959901757555568 0.12369078970909482 0.24863972900027057 0.028807830567091165 0.07054282666513552 1.3045647491887012e-07 6.8845343607818466 0.6077146043289655 RNK(ub)TPVQDCPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RNKTPVQDCPR 11 2 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4 A3QJZ7 LOC101929983;PRAMEF25;PRAMEF6 PRAME family member 6 1 2353190.0 528080.0 571310.0 1253800.0 True False 723325.4468254048 546067.6351304725 957678.2628215533 1.0 0.7549404455865653 1.323993600701727 19.464285381473825 -6.789724708755786 1.49791765808827 0.8629856543805025 1.3299586379915147 0.8002741309195996 0.10415559829556698 0.23576901288066587 1.0451571128912909 0.054737381136427114 0.12815262698388402 1.622838458695931e-07 6.789724708755786 0.46697298361101225 RNK(ub)TPVQDCPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RNKTPVQDCPR 11 2 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4 A3QJZ7 LOC101929983;PRAMEF25;PRAMEF6 PRAME family member 6 1 1911910.0 419670.0 415340.0 1076900.0 True False 543271.0879324521 392225.9638867971 880915.2499271134 1.0 0.7219709875957263 1.6215021735827078 19.051312745435816 -6.823709814674685 1.3558295355076815 0.8506820338541763 1.6427333852959582 0.8926873160928323 0.12318872293158821 0.18870454625370833 0.6805971629754146 0.07138123747677458 0.16437550353755206 1.500687224372308e-07 6.823709814674685 0.792051351441782 RNPDTQWITK(ub)PVHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RNPDTQWITKPVHK 14 2 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 124898400.0 19927400.0 22221000.0 82750000.0 True False 26125014.377216123 18905713.41677959 74187823.7940499 1.0 0.7236632732063659 2.8397237499225962 24.638928495354634 -6.8740414675377135 1.1124288925436734 0.839140362954164 2.973590619328434 0.9685560570363282 0.16654084928338725 0.13304216888867565 0.30525998120147435 0.11587238746534839 0.27644210146365306 1.336467901111965e-07 6.8740414675377135 2.13445025637427 up RNPDTQWITK(ub)PVHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RNPDTQWITKPVHK 14 2 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 194556200.0 17954000.0 21909200.0 154693000.0 True False 17384060.097522743 30657657.814968612 114174262.6094753 1.0 1.7635499211911594 6.567755861920042 24.05126173131738 -6.934837676422339 0.705951895879685 0.9383827837509807 7.687660557718737 0.9974065627439985 0.12550602491398508 0.09020251510317218 0.06593667657351146 0.11783270012501214 0.4237327962934631 1.1618828024829727e-07 6.934837676422339 6.749277773967757 RNPDTQWITK(ub)PVHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RNPDTQWITKPVHK 14 2 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 407164000.0 56904000.0 97195000.0 253065000.0 True False 86327528.23964195 79849792.86199884 203046591.82767004 1.0 0.9249632705843128 2.3520491779171575 26.36331734553905 -6.894492392961056 0.9954110346738488 0.9313731740561466 2.4861721137344084 0.9836219071955515 0.08392270059031454 0.11557445312346609 0.20115350412830188 0.06382911379532694 0.16193122908822394 1.2749924323300278e-07 6.894492392961056 1.5547989396782618 up RNPDTQWITK(ub)PVHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RNPDTQWITKPVHK 14 2 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 131760600.0 19927400.0 20320200.0 91513000.0 True False 27295098.297736317 19422386.37408454 69899514.16939607 1.0 0.7115704864743172 2.5608815695378206 24.702138556877525 -6.86704655710133 1.149538146893379 0.8394392898326554 2.663306881938332 0.9616491685174264 0.15908926433835466 0.13972178294255963 0.34691989732492123 0.10758213124715262 0.2534906892163759 1.3581678408982603e-07 6.86704655710133 1.8238675921056768 up RNPDTQWITK(ub)PVHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RNPDTQWITKPVHK 14 2 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 129694000.0 17954000.0 40728000.0 71012000.0 True False 14929546.497059831 40508590.18012494 85860280.87760939 1.0 2.7133168571531994 5.751030742596125 23.831667006751655 -6.962330632743261 0.4012378726391189 0.8352759343832395 7.740212455851955 0.9998471113081931 0.024291419913515612 0.07887884053597612 0.018130511426018858 0.03908139089896099 0.2543941882193071 1.090609728193273e-07 6.962330632743261 6.9049365214687155 RNPDTQWITK(ub)PVHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RNPDTQWITKPVHK 14 2 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 1 394964000.0 56904000.0 100244000.0 237816000.0 True False 73663349.74553402 94665333.27844201 194535928.19822285 1.0 1.2851076363681286 2.6408781146966094 26.134443667631498 -6.940930499146312 0.6508482532496639 0.9849924462158283 3.0167177660799287 0.9982832692810955 0.029659844505362246 0.08734466289109549 0.05269545942792242 0.02907941906171527 0.11621835333419048 1.1456962744174897e-07 6.940930499146312 2.0317253198641003 up RNPDTQWITKPVHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RNPDTQWITKPVHK 14 2 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 7263710.0 670610.0 4789600.0 1803500.0 False True 879176.204196477 4075010.3497145735 1616891.1203935838 1.0 4.6350325796623775 1.8390979108349974 19.745792813234964 -6.579740990166575 2.267460611802887 3.4756582612316804 1.8458819858902664 0.0 1.5792458003367467 0.7000781151182175 6.769433798656592 0.5848500641559524 1.7658587765027756 2.631837131025338e-07 6.579740990166575 -1.629776275341414 RNPDTQWITKPVHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RNPDTQWITKPVHK 14 2 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 5855920.0 2169500.0 481220.0 3205200.0 False True 2100630.41002426 673373.6555291474 2365661.966061102 1.0 0.3205578917242137 1.1261676279521162 21.002390922420734 -6.683085565689869 1.8906885755649925 0.5713157242878596 1.1231982638556581 0.33843036261653814 0.2877696711565632 0.43169097272600077 2.9860911790602573 0.1220053112368289 0.3205421675966631 2.0745047535279443e-07 6.683085565689869 0.5518825395677985 RNPDTQWITKPVHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RNPDTQWITKPVHK 14 2 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 8170010.0 670610.0 2091800.0 5407600.0 False True 918552.6395538264 1999377.3593424293 4130436.253017895 1.0 2.1766606215552304 4.496678878440973 19.809002874757855 -6.960322641814545 0.4308625932442026 0.908684031272356 5.853751180174156 0.9997819789948106 0.02145031026932035 0.07958606973887485 0.020706943599389495 0.030277818094848055 0.19259505305703783 1.0956639137783059e-07 6.960322641814545 4.9450671489018 RNPDTQWITKPVHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RNPDTQWITKPVHK 14 2 P61313;A0A2R8YEM3;E7EQV9;E7ENU7 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 5906300.0 1096800.0 1793600.0 3015900.0 False True 1419829.22116023 1693784.5832988855 2467037.1457472234 1.0 1.19294951678399 1.7375590732885855 20.437285980320198 -6.952813008837183 0.5270601608221565 0.9912253295992969 1.9638822618058607 0.9994039353526357 0.007624803401425579 0.08237551127001091 0.03143722127753953 0.008543975828112225 0.045019763852753816 1.1147744109616595e-07 6.952813008837183 0.9726569322065638 RNPGVVIYVNSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RNPGVVIYVNSR 12 1 H0Y6Y8;B1AL05;Q8N983-4;Q8N983-3;Q8N983-2;Q8N983;Q8N983-6;Q8N983-7;H0YBU8 H0Y6Y8 MRPL43 39S ribosomal protein L43, mitochondrial 0 4391820.0 1759400.0 815620.0 1816800.0 False True 2409897.7259972347 779583.2115053402 1387709.2581705193 1.0 0.32349223915000064 0.575837407206264 21.200540490332312 -10.282844597578602 5.63775347531536 1.0000498289701039 0.44966482317827716 0.8637911152013702 0.10301948346581602 6.452801869153484e-05 8.20821476890791e-06 0.09975717509362832 0.03324939531649525 5.213812421717328e-11 10.282844597578602 -0.5503850057918267 RNPGVVIYVNSRPCCVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RNPGVVIYVNSRPCCVPR 18 2 H0Y6Y8;B1AL05;Q8N983-4;Q8N983-3;Q8N983-2;Q8N983;Q8N983-6;Q8N983-7;H0YBU8 H0Y6Y8 MRPL43 39S ribosomal protein L43, mitochondrial 0 13230400.0 3677500.0 4163500.0 5389400.0 False True 5037171.1307007065 3979542.8031466682 4116534.7181771225 1.0 0.7900352598489314 0.817231460151818 22.264182314658044 -9.930650960947997 6.629171787431782 1.0000000160018176 0.8036333600600536 0.9858179456710903 0.011102802280778987 2.629349525542838e-09 4.1079777334454977e-10 0.010750243043563005 0.0035834140274723482 1.1731378283984483e-10 9.930650960947997 -0.19636665594176406 RPAEDMEEEQAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPAEDMEEEQAFK 13 1 P61978;P61978-2;S4R457;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 10050500.0 3172200.0 1140100.0 5738200.0 False True 3071500.2473744885 1595347.875542957 4235193.277689946 1.0 0.5194034664026665 1.3788679591708253 21.550512068818726 -6.754943845657952 1.6313461764870438 0.719094594072056 1.3812627859964264 0.6700375498667135 0.20202088632606982 0.29150364923775923 1.5276949490384975 0.09776293436166954 0.23614222128455994 1.7581509284428433e-07 6.754943845657952 0.6621681919243704 RPAEDMEEEQAFK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPAEDMEEEQAFKR 14 2 P61978;P61978-2;S4R457;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 25771200.0 8685900.0 12265800.0 4819500.0 True False 11387299.014375258 10435790.451713936 4320824.371908439 1.0 0.9164412419960042 0.3794424267294515 23.440922254921805 -6.934399319120891 0.7097530360576795 1.0069866693762768 0.25573938986214123 0.9973344177254335 0.014196135975699234 0.0904170370318061 0.06695566921512588 0.013290270071451666 0.04746885024790109 1.1630561467456315e-07 6.934399319120891 -0.7512472795141356 down RPAEDMEEEQAFK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 2 RPAEDMEEEQAFKR 14 2 P61978;P61978-2;S4R457;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 41899800.0 14593500.0 13130800.0 14175500.0 True False 14130237.33057804 18373996.916217387 10462511.294115543 1.0 1.3003317981401337 0.7404342226775282 23.75228236150211 -6.760979339035888 1.6085864328290678 1.1742345047203853 0.7382744984554691 0.6950386052010145 0.12633938942149478 0.28126987035019574 1.4346077841736138 0.06196018163974713 0.14876817564880307 1.7338864830625489e-07 6.760979339035888 -0.43596000626491616 RPAEDMEEEQAFK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 2 RPAEDMEEEQAFKR 14 2 P61978;P61978-2;S4R457;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 109062400.0 27133100.0 32474500.0 49454800.0 True False 41162896.395315364 26679171.75057339 39680037.10319118 1.0 0.6481364064947012 0.9639758272138269 25.294841164133942 -10.307332917479664 7.944903613701292 1.0000006088397184 0.8060561178480655 0.33455647725934357 0.12894090356967988 1.390494141781554e-06 1.2129427926078557e-07 0.1248468855635134 0.041615497680858884 4.927958961697868e-11 10.307332917479664 -0.1939444909916529 RPAEDMEEEQAFK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPAEDMEEEQAFKR 14 2 P61978;P61978-2;S4R457;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 25240100.0 8685900.0 7764600.0 8789600.0 True False 11897311.957621561 7421534.297901431 6713677.507494275 1.0 0.6237992518257124 0.5643020483457537 23.504132316444696 -13.999999999999998 0.25957793755995834 3.7479188404002928 0.5424681401382051 0.9995614732868997 0.0040395562462531495 14.398477444264808 0.161225498998727 20.749199129348774 0.02606931503777951 1.0000000000000041e-14 13.999999999999998 -3.205450700262088 RPAEDMEEEQAFK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 2 RPAEDMEEEQAFKR 14 2 P61978;P61978-2;S4R457;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 43516930.0 14593500.0 21464400.0 7459030.0 True False 12135141.851667741 21348767.016850177 9018678.686341943 1.0 1.7592515421578034 0.7431869191625889 23.532687636936387 -6.706678926235535 1.8070817739467901 1.468342753011721 0.7458009143074049 0.44933110224468986 0.320114913642447 0.3817728899300886 2.4281018579651095 0.14108373545451863 0.3598646853224094 1.964812325111913e-07 6.706678926235535 -0.7225418387043161 RPAEDMEEEQAFK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 2 RPAEDMEEEQAFKR 14 2 P61978;P61978-2;S4R457;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 126370000.0 27133100.0 32930900.0 66306000.0 True False 35124332.823361196 31098266.466412384 54238988.35701285 1.0 0.8853767165572729 1.5441998181083882 25.06596748622639 -6.86202722378334 1.175538318514615 0.937449829674546 1.5773473959081317 0.9560523215584457 0.06024769153667572 0.14472287805645023 0.37888947846160675 0.039941156406126374 0.09345210973221216 1.373955845784095e-07 6.86202722378334 0.6398975662335856 RPAESK(ub)NNTVVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPAESKNNTVVGK 13 2 Q8WWK9-6;Q8WWK9-5;Q8WWK9;Q8WWK9-4;C9J7Y4;C9J649 Q8WWK9-6 CKAP2 Cytoskeleton-associated protein 2 1 5665880.0 3081300.0 1831900.0 752680.0 True False 4039614.1393516427 1558587.6606902708 674799.89381638 1.0 0.38582587517639094 0.16704563122573018 21.945786063828525 -11.141861281281727 0.19914185974258458 2.066542997008338 2.2770639423781304e-11 0.9993810422498808 0.008772076094271924 3.3654861143965387 0.11351942118220817 1.7506068145989178 0.136028380642849 7.213378461036629e-12 11.141861281281727 -2.0665429969855675 RPAESK(ub)NNTVVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPAESKNNTVVGK 13 2 Q8WWK9-6;Q8WWK9-5;Q8WWK9;Q8WWK9-4;C9J7Y4;C9J649 Q8WWK9-6 CKAP2 Cytoskeleton-associated protein 2 1 9379100.0 3197700.0 5038400.0 1143000.0 True False 3096190.7638324862 7050259.394908891 843614.0107350056 1.0 2.2770752620494323 0.2724683571146548 21.562062931490164 -6.734575203551162 1.7064614872609933 1.7645694933972174 0.27259152928716585 0.5804493523723947 0.5366838496002732 0.3276899049162467 1.8713927458723039 0.24902201171778002 0.6147769351905688 1.8425733965883834e-07 6.734575203551162 -1.4919779641100515 RPAESK(ub)NNTVVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPAESKNNTVVGK 13 2 Q8WWK9-6;Q8WWK9-5;Q8WWK9;Q8WWK9-4;C9J7Y4;C9J649 Q8WWK9-6 CKAP2 Cytoskeleton-associated protein 2 1 7173700.0 3081300.0 3009200.0 1083200.0 True False 4220539.879001515 2876243.5939063216 827370.4692042643 1.0 0.681487126378433 0.19603427355838696 22.008996125351416 -7.301427358684791 0.446258739297683 1.0205031379183718 1.195004581698255e-11 0.9991310580398222 0.009744417777254745 0.10113248005021233 0.0391193539136011 0.012739740295547352 0.05405912440060403 4.9954272814101497e-08 7.301427358684791 -1.0205031379064218 down RPAESK(ub)NNTVVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPAESKNNTVVGK 13 2 Q8WWK9-6;Q8WWK9-5;Q8WWK9;Q8WWK9-4;C9J7Y4;C9J649 Q8WWK9-6 CKAP2 Cytoskeleton-associated protein 2 1 7457630.0 3197700.0 3691400.0 568530.0 True False 2659029.2321292306 3671513.695514472 687406.994414285 1.0 1.3807722198580306 0.2585180283497074 21.34246820692444 -6.815145331669282 1.3927227827441686 1.2062848837880684 0.23646872259934634 0.8728843687491786 0.16613720203630972 0.1998456465403554 0.7629453511956059 0.09377151173995273 0.21645987752844972 1.5305751865348303e-07 6.815145331669282 -0.969816161188722 down RPAVK(ub)QFHDSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPAVKQFHDSK 11 2 Q02543;M0R3D6;M0R1A7;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 1 23235600.0 1745500.0 5664100.0 15826000.0 True False 2288367.403446047 4819038.358488872 14188477.333711585 1.0 2.1058848990908947 6.20026194759862 21.125887268545714 -6.946652863592177 0.5944563379895967 0.9532620932574896 7.5604912095069015 0.9989117491152266 0.07378913911558584 0.0848582856042899 0.041744125979926765 0.07615290028070187 0.34347390544685963 1.1306993341168452e-07 6.946652863592177 6.607229116249412 RPAVK(ub)QFHDSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPAVKQFHDSK 11 2 Q02543;M0R3D6;M0R1A7;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 1 20363200.0 3422600.0 5117600.0 11823000.0 True False 3313951.436436517 7161084.367931437 8726201.617602775 1.0 2.160889954269134 2.6331712413341926 21.66012103038518 -9.783553374138855 0.23573238573773042 6.727072566783847e-17 2.946262201953104 0.9991881322846797 0.0195523950402773 1.2166669239479255 0.101697397851096 1.0629544368889305 0.22617661024134716 1.6460636551483577e-10 9.783553374138855 2.946262201953104 RPAVK(ub)QFHDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPAVKQFHDSK 11 2 Q02543;M0R3D6;M0R1A7;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 1 25450300.0 1745500.0 4741800.0 18963000.0 True False 2390858.520363859 4532291.596964303 14484329.955244137 1.0 1.8956753644605224 6.058212910498695 21.189097330068606 -6.941448963030649 0.6459424078233964 0.9541948067932358 7.230242119514889 0.998347601569185 0.08958777386333171 0.0871117694479479 0.05164565968647608 0.08819599921083782 0.35603645191919203 1.1443293500275338e-07 6.941448963030649 6.276047312721653 RPAVK(ub)QFHDSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPAVKQFHDSK 11 2 Q02543;M0R3D6;M0R1A7;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 1 14150200.0 3422600.0 3934400.0 6793200.0 True False 2846043.546888542 3913204.606282745 8213626.711792025 1.0 1.37496301156772 2.885980687390266 21.440526305819457 -6.944704163125267 0.6142412669488273 0.9833764305553215 3.356831335860719 0.9987174008074201 0.029194432612862586 0.08568456270792518 0.04531846242369529 0.029557511745419308 0.12760598056970168 1.1357842366037808e-07 6.944704163125267 2.3734549053053975 up RPAVVYIGSAGKPHER ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPAVVYIGSAGKPHER 16 2 Q9BUQ8 Q9BUQ8 DDX23 Probable ATP-dependent RNA helicase DDX23 0 9358800.0 1562800.0 3700200.0 4095800.0 False True 2048845.9341767263 3148144.5832666303 3672005.9056878537 1.0 1.5365452964288542 1.7922313456738028 20.96638007228927 -10.61177198876462 0.15066181784538976 1.0486597977339379e-16 2.146290390273728 0.9996727057002905 0.005972514182065706 2.5124910568758185 0.0813605130826614 1.1481492330754695 0.23419914928678162 2.4447137278630896e-11 10.61177198876462 2.146290390273728 RPAVVYIGSAGKPHER ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPAVVYIGSAGKPHER 16 2 Q9BUQ8 Q9BUQ8 DDX23 Probable ATP-dependent RNA helicase DDX23 0 6664200.0 2742900.0 1229300.0 2692000.0 False True 2655828.1408875524 1720165.9007148123 1986884.4417310895 1.0 0.6476947337940132 0.7481223694945456 21.340730361976174 -10.248708356187379 7.933538987832705 1.0000003309305672 0.6979085516442799 0.923456660791567 0.04099941059006996 2.3999360631596767e-07 2.2741400239099703e-08 0.039697552377371985 0.013232502868305086 5.640162851846252e-11 10.248708356187379 -0.3020917792862873 RPAVVYIGSAGKPHER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPAVVYIGSAGKPHER 16 2 Q9BUQ8 Q9BUQ8 DDX23 Probable ATP-dependent RNA helicase DDX23 0 5181800.0 2742900.0 1286900.0 1152000.0 False True 2280842.881073042 1279967.2142703508 1392877.8737538166 1.0 0.561181668799641 0.6106855870311091 21.12113563741045 -10.799436230061527 10.856380186950318 1.0027521583755723 0.5859336281157832 0.9893935608357771 0.02020988998925969 0.001348811564690706 2.4918258024445357e-05 0.01960542525864735 0.006522713946423901 1.5869519230563903e-11 10.799436230061527 -0.4168185302597891 RPDQQLQGEGK(ub)IIDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPDQQLQGEGKIIDR 15 2 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 13246500.0 4612800.0 5451300.0 3182400.0 True False 4466369.188919062 7628032.5181539515 2348833.9700464425 1.0 1.7078822183080808 0.5258933757365679 22.090671078211535 -6.744500349452174 1.6700895479464875 1.418976033013457 0.5244802084075254 0.6250149870261501 0.29741154876990195 0.30973885475588014 1.6979128298717512 0.14078171211920593 0.3437913134966245 1.8009416853255566e-07 6.744500349452174 -0.8944958246059317 RPELGVTLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPELGVTLTK 10 1 P46976-2;P46976;C9JQ42;G5E9W8;C9J8R8;C9J7C7;P46976-3 P46976-2;P46976-3 GYG1 Glycogenin-1 0 22844300.0 8285500.0 6795700.0 7763100.0 False True 10862370.736896133 5781808.049431126 6959848.880913455 1.0 0.5322786516383667 0.6407301913635657 23.37283567316389 -9.836551503328659 6.421588503240683 1.0000000139727974 0.5865044215009128 0.9509382224301438 0.044275155691257735 8.83205795274246e-09 1.591634651577045e-09 0.0428692364382263 0.014289745053541806 1.4569629120921482e-10 9.836551503328659 -0.4134955924718846 RPELGVTLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPELGVTLTK 10 1 P46976-2;P46976;C9JQ42;G5E9W8;C9J8R8;C9J7C7;P46976-3 P46976-2;P46976-3 GYG1 Glycogenin-1 0 14742500.0 4436300.0 1738600.0 8567600.0 False True 4295472.084807847 2432832.0466792244 6323488.537509391 1.0 0.5663712855412618 1.4721288865720252 22.034385265759802 -6.77650688692976 1.54930698570029 0.7533541313485896 1.4785545240428615 0.7548868385668785 0.18312617159489558 0.25604417297979293 1.213649559521865 0.09311647765624162 0.22038186256042536 1.6729891063590052e-07 6.77650688692976 0.7252003926942718 RPELGVTLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPELGVTLTK 10 1 P46976-2;P46976;C9JQ42;G5E9W8;C9J8R8;C9J7C7;P46976-3 P46976-2;P46976-3 GYG1 Glycogenin-1 0 23837200.0 5353800.0 14031000.0 4452400.0 False True 8122106.015207972 11527058.425296636 3572381.1884437553 1.0 1.419220384923956 0.4398343461356903 22.95342242773842 -6.790393159256448 1.494800028346833 1.2341806981685626 0.4293100766027243 0.8025902837329778 0.17826105799449804 0.23476249053505832 1.0362834774938015 0.0938656814880348 0.2196961442989327 1.6203425651933595e-07 6.790393159256448 -0.8048706215658383 down RPELGVTLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPELGVTLTK 10 1 P46976-2;P46976;C9JQ42;G5E9W8;C9J8R8;C9J7C7;P46976-3 P46976-2;P46976-3 GYG1 Glycogenin-1 0 21950000.0 8285500.0 4878500.0 8786000.0 False True 11348873.257218406 4662951.738957856 6710927.753349941 1.0 0.4108735407712835 0.5913298704857315 23.436045734686783 -10.39821170905301 5.212208760802049 1.0003642216998787 0.5011017056284935 0.9106428048270205 0.07367098810937105 0.00031202857642559194 3.602606453086347e-05 0.07138232323470924 0.023777209170510617 3.997498329632704e-11 10.39821170905301 -0.49926251607138517 RPELGVTLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPELGVTLTK 10 1 P46976-2;P46976;C9JQ42;G5E9W8;C9J8R8;C9J7C7;P46976-3 P46976-2;P46976-3 GYG1 Glycogenin-1 0 10057500.0 4436300.0 3024100.0 2597100.0 False True 3688980.0114128585 3007808.573063146 3140141.6023663487 1.0 0.815349653226007 0.8512221786649617 21.81479054119408 -10.326654570128543 5.680546323345131 1.0000249460842476 0.8332859159454848 0.9664404780709525 0.014644897185078814 4.627491302374869e-06 5.48514718015326e-07 0.014181980892934166 0.00472662024206024 4.7135208214779344e-11 10.326654570128543 -0.1667390301387628 RPELGVTLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPELGVTLTK 10 1 P46976-2;P46976;C9JQ42;G5E9W8;C9J8R8;C9J7C7;P46976-3 P46976-2;P46976-3 GYG1 Glycogenin-1 0 17832200.0 5353800.0 8083300.0 4395100.0 False True 6930599.639175444 7633457.249208231 3595236.8975342675 1.0 1.1014136794253504 0.5187483168428995 22.72454874983087 -6.862008575437969 1.1756453874662331 1.0553376581395173 0.4894445297938516 0.9560298082360953 0.05329549765266658 0.14474114253462053 0.3790189800269286 0.035329500070404675 0.08265943836186321 1.374014843893233e-07 6.862008575437969 -0.5658931283456656 RPENPK(ub)PQDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPENPKPQDGK 11 2 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 2571960.0 838710.0 1319400.0 413850.0 True False 1099556.9320791934 1122550.6629809197 371028.7719295176 1.0 1.0209118147782004 0.3374347986037662 20.068490874291864 -6.899840972043002 0.9622610310853572 1.028540603843172 0.26592069445098737 0.9864873627952421 0.0368934829808179 0.11152283103805331 0.17807573678569716 0.02876381887035366 0.07477997449582456 1.2593864837258191e-07 6.899840972043002 -0.7626199093921846 down RPENPKPQDGK(ub)ETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPENPKPQDGKETK 14 3 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 83557000.0 20926000.0 46888000.0 15743000.0 True False 27434188.647672255 39892493.16799252 14114065.377519364 1.0 1.4541160185314002 0.5144699396355911 24.70947157367019 -6.775295660336014 1.5542366809063568 1.2587028439741004 0.5081001834603077 0.7503829907618572 0.19169317638855832 0.257951209777433 1.2304037276483868 0.09717754110917064 0.23021270322298865 1.677661505694225e-07 6.775295660336014 -0.7506026605137927 RPENPKPQDGK(ub)ETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPENPKPQDGKETK 14 3 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 69401530.0 23326000.0 32044530.0 14031000.0 True False 22585528.898006864 44840077.9390164 10355860.179022634 1.0 1.9853454900927057 0.45851749701272315 24.428895362782065 -6.7324698588626175 1.7140117842439526 1.5913613160127897 0.4589845281272971 0.5706486574752339 0.4141460234372282 0.3316900183549936 1.9100941155177338 0.19138019006714316 0.473613425362848 1.8515273904382066e-07 6.7324698588626175 -1.1323767878854927 RPENPKPQDGK(ub)ETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPENPKPQDGKETK 14 3 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 5409600.0 2128800.0 2058400.0 1222400.0 True False 3229545.2361266296 1691062.4376473934 980792.1042030466 1.0 0.5236224650860061 0.30369356441632145 21.62289959747074 -11.128830493852465 0.14567022821975442 2.0434764161702925 4.583685555071045e-12 0.9996720972405229 0.005262593106510501 3.4578214455050387 0.0867517478598892 1.4056286504615327 0.21393239822004254 7.433091965979417e-12 11.128830493852465 -2.0434764161657086 RPENPKPQDGK(ub)ETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPENPKPQDGKETK 14 3 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 34939400.0 20926000.0 172400.0 13841000.0 True False 28662907.703886595 164782.7979494381 10572040.86434288 1.0 0.005748990983461671 0.36884048797705704 24.77268163519308 -10.600676769223432 6.431142709736886 1.0021969915494642 0.1872947394802673 0.8697906908629967 0.14823148292960017 0.004677030740344053 0.0002904066225984736 0.14375981708438626 0.047841505397497555 2.5079751601428073e-11 10.600676769223432 -0.8149022520691969 RPENPKPQDGK(ub)ETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPENPKPQDGKETK 14 3 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 58510100.0 23326000.0 27676000.0 7508100.0 True False 19396602.517011102 27526903.894744117 9078008.996467898 1.0 1.4191611067248824 0.4680205715669201 24.20930063821634 -6.786919893568385 1.5087279634668367 1.2352076510103835 0.4587595084999036 0.7911710580482514 0.1778608619066075 0.23996549503431197 1.0791328604888943 0.0928113726031945 0.2177813740255359 1.633353195170528e-07 6.786919893568385 -0.7764481425104799 down RPEPPSTSTLK(ub)QVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPEPPSTSTLKQVTK 15 2 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 122894000.0 59714000.0 13826000.0 49354000.0 True False 78285632.27119863 11763214.693325903 44247321.516997464 1.0 0.15026019912026184 0.5652036042030678 26.222244218814726 -9.656996990860405 12.463252461187768 0.9999999988143385 0.35773190182519393 0.7615887206241598 0.16939993576430976 0.0 0.0 0.16402078129389439 0.05467359417198147 2.2029417267431572e-10 9.656996990860405 -0.6422680969891446 RPEPPSTSTLK(ub)QVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPEPPSTSTLKQVTK 15 2 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 192163000.0 72569000.0 86390000.0 33204000.0 True False 70265336.8172623 120885977.5178985 24506876.3013518 1.0 1.7204212346164982 0.3487761876825035 26.066309821008048 -6.7639842151960545 1.5974150113161139 1.4163777773197315 0.34274203176955437 0.7070548174657978 0.3032099392015101 0.276267394062291 1.3902250051104528 0.1497014867400422 0.3583637599247323 1.7219311589076156e-07 6.7639842151960545 -1.073635745550177 RPEPPSTSTLK(ub)QVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPEPPSTSTLKQVTK 15 2 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 162431000.0 59714000.0 47186000.0 55531000.0 True False 81791879.51017325 45101166.49676448 42415721.49684455 1.0 0.5514137438442751 0.5185810834872537 26.285454280337618 -13.999999999999998 0.37105421455199017 7.290013933640073 0.515233437065805 0.9997926998022291 0.0031619766521984 22.94304929830802 0.19781010171438143 114.84102981709417 0.00914570511842198 1.0000000000000041e-14 13.999999999999998 -6.774780496574268 RPEPPSTSTLK(ub)QVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPEPPSTSTLKQVTK 15 2 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 254635000.0 72569000.0 122214000.0 59852000.0 True False 60344338.85179539 121555608.9244203 72366776.47561914 1.0 2.0143664051562267 1.1992305799115743 25.846715096442324 -10.255519936899956 4.811454138446808 0.9998411406385217 1.6067984925349115 0.4249137276822623 0.3327778071554609 0.0005672282407779253 8.776689442615662e-05 0.3222940576499117 0.10740357542454866 5.552391275002196e-11 10.255519936899956 0.6069573518963898 RPEPPSTSTLK(ub)QVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPEPPSTSTLKQVTK 15 2 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 250328000.0 109361000.0 124104000.0 16863000.0 True False 141569970.32759297 117197503.30381632 13794107.028991463 1.0 0.8278415474173036 0.09743667387279868 27.076940034025313 -7.107592220115811 0.7324761594808789 0.9992201490249427 5.384314937626457e-23 0.9969080454273883 0.02175607515827801 0.07901239562337009 0.07151236609133671 0.02020599544146739 0.05401959361888815 7.805626742200334e-08 7.107592220115811 -0.9992201490249427 down RPETISEPK(ub)TYVDLTNEETTDSTTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPETISEPKTYVDLTNEETTDSTTSK 26 2 O95551;O95551-2 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 378493600.0 114152000.0 156359700.0 107981900.0 True False 149654377.44954067 133031442.24533677 96808968.82352531 1.0 0.8889244973150973 0.6468836426529964 27.15705923795082 -6.958334171770693 0.45831428228083215 1.007175082610623 0.5189035739216653 0.999703316386342 0.0025393521510224393 0.08030174341451747 0.02337190852533547 0.0032778747500105993 0.01999877962104595 1.100692046283411e-07 6.958334171770693 -0.48827150868895763 RPETISEPK(ub)TYVDLTNEETTDSTTSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPETISEPKTYVDLTNEETTDSTTSK 26 2 O95551;O95551-2 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 452832200.0 128982000.0 153713200.0 170137000.0 True False 124887537.01117724 215091682.36374837 125573015.69940656 1.0 1.7222830036635122 1.005488767771663 26.896054271358626 -10.56590190791556 5.773045234480289 0.9988652584374931 1.3638858857175484 0.2557427027732825 0.2926300214171986 0.004286234834808789 0.0003222979415393439 0.2841564906376957 0.09444593329576081 2.7170528876983674e-11 10.56590190791556 0.36502062728005535 RPETISEPK(ub)TYVDLTNEETTDSTTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPETISEPKTYVDLTNEETTDSTTSK 26 2 O95551;O95551-2 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 363412200.0 114152000.0 123690200.0 125570000.0 True False 156357079.24180767 118225157.9752065 95912952.19532812 1.0 0.75612283465829 0.613422511218682 27.22026929947371 -13.083902720686066 0.06394500472471762 2.358834599314122 1.5724006406267817e-11 0.9999554129060673 0.001065765277849202 9.018091529911743 0.058151369927427816 2.1287457191294332 0.5185105059241729 8.243227375983693e-14 13.083902720686066 -2.3588345992983983 RPETISEPK(ub)TYVDLTNEETTDSTTSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPETISEPKTYVDLTNEETTDSTTSK 26 2 O95551;O95551-2 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 384234600.0 128982000.0 177801600.0 77451000.0 True False 107254247.8714364 176843747.48994544 93645646.00703707 1.0 1.648827445062359 0.8731182947577825 26.676459546792902 -6.684830548964775 1.88518625069104 1.4087341661024182 0.8759815459281041 0.3462089432907737 0.27470360016273754 0.42785169706278514 2.9439572700049497 0.11676205792857221 0.3060075340634279 2.0661861736301383e-07 6.684830548964775 -0.5327526201743141 RPFGISALIVGFDFDGTPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPFGISALIVGFDFDGTPR 19 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 0 132927000.0 33115000.0 55323000.0 44489000.0 False True 50237876.03078412 45450178.40942812 35695729.649778605 1.0 0.9046994419425244 0.7105342118346212 25.58227213511645 -6.959680957169334 0.43990883157080374 1.006949125562725 0.6007154768178645 0.9997581761359622 0.0018730638351272598 0.0798153069641243 0.021554072642914552 0.0025596627406697108 0.016088076582603892 1.0972839904780389e-07 6.959680957169334 -0.40623364874486045 RPFGISALIVGFDFDGTPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPFGISALIVGFDFDGTPR 19 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 0 80004000.0 33115000.0 26058000.0 20831000.0 False True 42868020.29423864 24607849.393177036 17039971.744109664 1.0 0.5740374578595661 0.39749845285950364 25.3533984572089 -13.999999999956296 0.12089331192583093 3.028939677293478 0.11909341069420037 0.9996885698044041 0.004462990969296827 11.960377402920653 0.10712104431314368 5.823479124515116 0.2470695749383921 1.0000000001006315e-14 13.999999999956296 -2.9098462665992777 RPFGVSLLYIGWDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPFGVSLLYIGWDK 14 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0;H0YLC2;H0YMV3 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 7603400.0 2752700.0 3749500.0 1101200.0 False True 3608816.3571847174 3190089.215436531 987258.3874562884 1.0 0.8839710585675685 0.27356847501834675 21.78309429961395 -6.938677949782184 0.6717526226325661 1.007033436728859 0.11517399577419128 0.9979855235092512 0.014301286934317087 0.0883750555013752 0.05739583075498151 0.0137855213531376 0.05284952226036003 1.151654079193673e-07 6.938677949782184 -0.8918594409546676 down RPFGVSLLYIGWDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPFGVSLLYIGWDK 14 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0;H0YLC2;H0YMV3 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 25019000.0 10756000.0 8897900.0 5365100.0 False True 10414556.667536743 12450877.871935526 3959819.3604500294 1.0 1.1955264414419298 0.3802196758689881 23.312098091476866 -6.843394683066803 1.266520057130915 1.1040146436383176 0.3515474693412366 0.9301376386024464 0.09186113335378443 0.1648704776015632 0.512248195229131 0.05683866065726448 0.13109046146633382 1.4341854655862947e-07 6.843394683066803 -0.752467174297081 down RPFGVSLLYIGWDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPFGVSLLYIGWDK 14 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0;H0YLC2;H0YMV3 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 130659000.0 20304000.0 57001000.0 53354000.0 False True 30802652.421230342 46828726.19915423 42808558.514111094 1.0 1.5202822652661598 1.3897685799488433 24.87655125117699 -10.008029909870983 4.6113609824507265 0.9999896257688009 1.455025422576786 0.9418835264023889 0.053281989024672634 18375569.815959483 1.0056572839164277 2365.8344144071284 0.01823984204415318 9.816803323447126e-11 10.008029909870983 0.4550357968079851 RPFGVSLLYIGWDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPFGVSLLYIGWDK 14 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0;H0YLC2;H0YMV3 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 22647300.0 2752700.0 8124500.0 11770100.0 False True 3770447.578920415 7765532.72587129 8990244.792818595 1.0 2.059578488582191 2.3843972378984124 21.84630436113684 -10.306043591785128 0.2653172290421055 7.14297474054305e-11 2.534155728937318 0.9990795914187114 0.017933434136870555 1.8404787925446686 0.1265379371286668 1.4167417876836566 0.13586105868721063 4.942610736374463e-11 10.306043591785128 2.5341557288658887 RPFGVSLLYIGWDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPFGVSLLYIGWDK 14 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0;H0YLC2;H0YMV3 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 21443100.0 10756000.0 6115500.0 4571600.0 False True 8944090.571592715 6082554.5876682885 5527500.4233098505 1.0 0.6800640645329624 0.6180058642144926 23.092503366911142 -13.999999999999998 0.23059245118352423 3.025214197610841 0.5880022219211346 0.9995106078345011 0.0037027020308683495 13.30977607930623 0.15204151643642175 12.345491548370218 0.03209536750272491 1.0000000000000041e-14 13.999999999999998 -2.4372119756897064 RPFGVSLLYIGWDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPFGVSLLYIGWDK 14 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0;H0YLC2;H0YMV3 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 89514000.0 20304000.0 34151000.0 35059000.0 False True 26283928.251675166 32250466.828858282 28678621.73571797 1.0 1.2270033048352598 1.0911086600569373 24.64767757326944 -10.326723043984236 4.406068965102569 0.9998281912383139 1.1590559824471747 0.6462131281216978 0.055478756417585276 39484899.43661231 18.363739695824272 68824.55981626212 0.01899185396961688 4.7127777139423876e-11 10.326723043984236 0.15922779120886077 RPFSQCLSTIISPLFAELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPFSQCLSTIISPLFAELK 19 1 B4DR80;Q9Y6E0-2;Q9Y6E0;H0Y630;Q5JV99 B4DR80 STK24 Serine/threonine-protein kinase 24;Serine/threonine-protein kinase 24 36 kDa subunit;Serine/threonine-protein kinase 24 12 kDa subunit 0 86924000.0 39095000.0 21674000.0 26155000.0 False True 59309973.22734433 17806105.36026508 20985452.785856247 1.0 0.30022109927467877 0.3538267114944691 25.821771384764165 -10.413966487022522 9.17998997975563 1.000002806841316 0.327023905384574 0.9952639007887907 0.021884399547998163 1.2571845252825692e-06 8.024473411913189e-08 0.02118956708242986 0.007063159582595499 3.8550810482238666e-11 10.413966487022522 -0.672978901456742 RPFSQCLSTIISPLFAELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPFSQCLSTIISPLFAELK 19 1 B4DR80;Q9Y6E0-2;Q9Y6E0;H0Y630;Q5JV99 B4DR80 STK24 Serine/threonine-protein kinase 24;Serine/threonine-protein kinase 24 36 kDa subunit;Serine/threonine-protein kinase 24 12 kDa subunit 0 61826100.0 39095000.0 14179000.0 8552100.0 False True 50609248.17766153 13389926.185657281 6995705.55195623 1.0 0.26457469074925866 0.13822978613312165 25.592897706856615 -13.999999999999998 0.24780627712123676 6.058533266858501 0.08635776980341854 0.9995386145864084 0.008161918344751438 13.912080357587135 0.15752568334768946 34.985424159644964 0.05902721054924166 1.0000000000000041e-14 13.999999999999998 -5.972175497055082 RPGAPESK(ub)CSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPGAPESKCSR 11 2 E7EQJ3;H0YBZ8;E7ESL3;H0YBZ2;P04233-3;P04233-2;P04233 E7EQJ3 CD74 HLA class II histocompatibility antigen gamma chain 1 7419700.0 2333400.0 3463700.0 1622600.0 True False 3059109.9966777405 2946929.4613968497 1454708.9170782513 1.0 0.9633290285727806 0.4755333801851181 21.54468055226096 -6.921961803178796 0.8100447161113108 1.010020957996395 0.3932096720958413 0.9947087030040539 0.01738966039752628 0.09703127433769161 0.09973378832609586 0.015140746188077812 0.04624031574236527 1.1968457909784338e-07 6.921961803178796 -0.6168112859005537 down RPGAPESK(ub)CSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPGAPESKCSR 11 2 E7EQJ3;H0YBZ8;E7ESL3;H0YBZ2;P04233-3;P04233-2;P04233 E7EQJ3 CD74 HLA class II histocompatibility antigen gamma chain 1 6533700.0 2333400.0 2618800.0 1581500.0 True False 3196121.037763974 2503092.756786476 1207982.2720149027 1.0 0.7831658210721754 0.37795260496768124 21.60789061378385 -6.961350135043109 0.4159687017782808 1.0187077558135444 0.1272255986808844 0.999817040936761 0.003487088660429389 0.07922230839863949 0.019374998706480445 0.005229847806061999 0.03376982948962068 1.093074756872236e-07 6.961350135043109 -0.8914821571326601 down RPGEK(ub)TYTQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPGEKTYTQR 10 2 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 11452300.0 3318100.0 4677100.0 3457100.0 True False 4350061.23252611 3979294.911193009 3099392.4548448375 1.0 0.9147675626814581 0.7124939832272199 22.052604278156807 -6.956567376366068 0.48138045394693674 1.0047926186394969 0.6140159313817849 0.999620934667328 0.0023474852574890265 0.08095092912838606 0.025841258557417264 0.002860033585362839 0.016685098766305088 1.1051789988155664e-07 6.956567376366068 -0.390776687257712 RPGEK(ub)TYTQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPGEKTYTQR 10 2 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 19059400.0 4993900.0 7808400.0 6257100.0 True False 4835371.378022657 10926334.840268066 4618177.801023624 1.0 2.259668179765792 0.9550823380420781 22.20519526867587 -6.654115556733215 1.9935662296957293 1.8147055924468372 0.9605285159444029 0.2110406163783225 0.5370959928453991 0.49850948795046074 3.802035823039018 0.21813279181480785 0.5951637515353346 2.2176062823614725e-07 6.654115556733215 -0.8541770765024342 RPGEK(ub)TYTQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPGEKTYTQR 10 2 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 11176800.0 3318100.0 4074000.0 3784700.0 True False 4544891.238280902 3893997.2090835916 2890831.8083432186 1.0 0.8567855653585431 0.6360618234368731 22.115814339679698 -6.964802853229435 0.36141974702051144 1.0187139341430362 0.4665527909498346 0.9999090224043673 0.0014278224496125044 0.07802791639436708 0.015096215700122163 0.002952978112082636 0.01883670035625942 1.084419071323391e-07 6.964802853229435 -0.5521611431932016 RPGEK(ub)TYTQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPGEKTYTQR 10 2 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 13229600.0 4993900.0 6081900.0 2153800.0 True False 4152649.1172812213 6049135.597537364 2604149.621953964 1.0 1.4566931678296455 0.6271056254468533 21.985600544110145 -6.757250464228283 1.6228472762929467 1.2661767959516734 0.6244822117530171 0.6796422588571844 0.19201780988909697 0.28755628950876416 1.4919521950281924 0.09338635609385133 0.22503321881452854 1.748837816388442e-07 6.757250464228283 -0.6416945841986563 RPHTPTPGIYMGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPHTPTPGIYMGR 13 1 P62995-3;P62995;H7BXF3;H7C2L4 P62995-3 TRA2B Transformer-2 protein homolog beta 0 7944700.0 1989900.0 2243100.0 3711700.0 False True 2608778.170219013 1908438.2235353158 3327648.889140483 1.0 0.7315448455224914 1.2755583924796179 21.314942843364136 -6.772507725417166 1.5646569431631503 0.8465150207917187 1.2789269802316061 0.7401231461839808 0.11322184538923069 0.2623967906783213 1.2680749138223264 0.057023439893658344 0.1354405770127842 1.6884658240628107e-07 6.772507725417166 0.4324119594398874 RPHTPTPGIYMGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPHTPTPGIYMGR 13 1 P62995-3;P62995;H7BXF3;H7C2L4 P62995-3 TRA2B Transformer-2 protein homolog beta 0 6639890.0 1127100.0 709990.0 4802800.0 False True 1091320.8274433468 993492.7095489389 3544802.5990884393 1.0 0.9103580583872927 3.2481764389972283 20.057643858079555 -6.897980642236205 0.9739195745174402 0.897343639017992 3.4837720259324345 0.9855353755675018 0.13007674139601538 0.11290793614848754 0.185909753293479 0.1005365288750184 0.2590340527812256 1.2647927216921758e-07 6.897980642236205 2.5864283869144424 up RPHTPTPGIYMGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPHTPTPGIYMGR 13 1 P62995-3;P62995;H7BXF3;H7C2L4 P62995-3 TRA2B Transformer-2 protein homolog beta 0 6200500.0 1989900.0 1645900.0 2564700.0 False True 2725619.8050255175 1573178.695736543 1958970.6816545217 1.0 0.577182001993053 0.7187248485803329 21.378152904887028 -10.393102363000912 5.091137896764383 1.0002862862988504 0.6479534252866659 0.8918717264335121 0.05778462514674007 0.0001879219611414364 2.240158233034254e-05 0.055994584112421274 0.01864990757166669 4.0448054459105164e-11 10.393102363000912 -0.35233286101218453 RPHTPTPGIYMGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPHTPTPGIYMGR 13 1 P62995-3;P62995;H7BXF3;H7C2L4 P62995-3 TRA2B Transformer-2 protein homolog beta 0 3256980.0 1127100.0 1253700.0 876180.0 False True 937233.588996107 1246946.0692600347 1059385.1870014044 1.0 1.330453884602736 1.1303320745643963 19.83804913351383 -10.230981096738894 4.268606597627858 0.9998822536855201 1.2303929795290327 0.6386252980590499 0.08169938687296234 9.348849388462609e-05 1.6842543351412348e-05 0.0791462410610458 0.02636836372379272 5.875149243635999e-11 10.230981096738894 0.23051072584351262 RPHTPTPGIYMGRPTYGSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPHTPTPGIYMGRPTYGSSR 20 2 P62995-3;P62995;H7BXF3;H7C2L4 P62995-3 TRA2B Transformer-2 protein homolog beta 0 38194100.0 10934600.0 8604400.0 18655100.0 False True 14335366.49081703 7320657.059688515 16724849.20435506 1.0 0.5106710780207812 1.1666844524043865 23.773075452482022 -6.707031895268254 1.8060166446093073 0.6982607875316718 1.1649976500100838 0.45091166142537553 0.20629888495545876 0.3810610948361311 2.4209888052760546 0.09097141962284945 0.23192573685334933 1.963216089871098e-07 6.707031895268254 0.46673686247841206 RPHTPTPGIYMGRPTYGSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPHTPTPGIYMGRPTYGSSR 20 2 P62995-3;P62995;H7BXF3;H7C2L4 P62995-3 TRA2B Transformer-2 protein homolog beta 0 32433700.0 2598300.0 4654400.0 25181000.0 False True 2515818.3887375114 6512926.192375357 18585340.68619263 1.0 2.588790280543134 7.387393608931816 21.262596350394922 -6.951299007818508 0.544395698063327 0.9313235814902106 9.26813576610515 0.9992993224834976 0.07187157109266147 0.08296828141058452 0.033835765055827145 0.07858185498932585 0.39768217234599434 1.1186674258772106e-07 6.951299007818508 8.336812184614939 RPHTPTPGIYMGRPTYGSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPHTPTPGIYMGRPTYGSSR 20 2 P62995-3;P62995;H7BXF3;H7C2L4 P62995-3 TRA2B Transformer-2 protein homolog beta 0 28652800.0 9272100.0 8206700.0 11174000.0 False True 14066453.581308587 6742150.265760239 8965454.002261812 1.0 0.4793070425881308 0.6373642048749978 23.74575530795475 -10.871522768129886 11.074156283078032 1.0166845856897746 0.5583356237315786 0.9123657528607962 0.06452656629918281 0.02335838203371061 0.0002709926219501333 0.05490351738299975 0.02082585972205699 1.344241292226216e-11 10.871522768129886 -0.45834896195819597 RPHTPTPGIYMGRPTYGSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPHTPTPGIYMGRPTYGSSR 20 2 P62995-3;P62995;H7BXF3;H7C2L4 P62995-3 TRA2B Transformer-2 protein homolog beta 0 32273600.0 10934600.0 10253800.0 11085200.0 False True 14977417.116454098 9800753.211217796 8467104.066860324 1.0 0.6543687162488617 0.5653247152713945 23.836285514004913 -13.999999999999998 0.19041996056313498 2.8554872880762723 0.5017128994772155 0.9994891814751934 0.00423724440184734 12.357554662437712 0.13838239248623502 8.50888308327332 0.0610326940868945 1.0000000000000041e-14 13.999999999999998 -2.3537743885990565 RPHTPTPGIYMGRPTYGSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPHTPTPGIYMGRPTYGSSR 20 2 P62995-3;P62995;H7BXF3;H7C2L4 P62995-3 TRA2B Transformer-2 protein homolog beta 0 16559300.0 2598300.0 9006300.0 4954700.0 False True 2160601.57420689 8957781.27428941 5990704.862055579 1.0 4.145966281440676 2.7727022573584104 21.0430016258292 -8.988124335548488 12.72519117531318 1.0000000090426255 3.4593342693999465 0.810472402514342 0.5606326901873778 0.0 2.2019644363293986e-17 0.5428302761974745 0.18094342270289104 1.0277220261969341e-09 8.988124335548488 2.4593342603573207 RPHTPTPGIYMGRPTYGSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPHTPTPGIYMGRPTYGSSR 20 2 P62995-3;P62995;H7BXF3;H7C2L4 P62995-3 TRA2B Transformer-2 protein homolog beta 0 79966100.0 9272100.0 19206000.0 51488000.0 False True 12002916.230415536 18137169.216569133 42117712.311493374 1.0 1.5110635505902579 3.5089566154570484 23.516881630047198 -6.94540192806071 0.6072310646489644 0.9778068096875168 4.145764014203539 0.998789246619644 0.037668987352712895 0.08538634028844003 0.04402060855464279 0.038390698227169485 0.16830521214931465 1.13396087909012e-07 6.94540192806071 3.167957204516022 RPIMSNHTATHILNFALR ddPTM_RPMI8226_Bortezomib_1h_R1 2 RPIMSNHTATHILNFALR 18 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 120551800.0 37756000.0 54312000.0 28483800.0 False True 49498481.62962412 46208861.30651785 25536569.611902837 1.0 0.933540985201908 0.5159061201711604 25.560880935282395 -6.9348647262987795 0.7057268883793388 1.0053520311730604 0.41848342014870327 0.9974107803878342 0.010902701515872132 0.09018969404995743 0.06587672429582143 0.010237839459427103 0.03683065250310579 1.1618104372819177e-07 6.9348647262987795 -0.5868686110243571 RPIMSNHTATHILNFALR ddPTM_RPMI8226_Bortezomib_2h_R1 2 RPIMSNHTATHILNFALR 18 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 201706100.0 57910100.0 44453000.0 99343000.0 False True 56071775.57388604 62203314.71933263 73322088.07388248 1.0 1.109351613760956 1.3076469814526495 25.740771419249963 -6.961914510754624 0.4075567588721314 0.9899676811720127 1.4343606390286798 0.9998347409969043 0.0016369077089250367 0.07902419429292895 0.018655745393205813 0.002551999572307978 0.016569507584144223 1.0916552035463974e-07 6.961914510754624 0.4443929578566671 RPIMSNHTATHILNFALR ddPTM_RPMI8226_Bortezomib_8h_R1 2 RPIMSNHTATHILNFALR 18 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 283588000.0 45205000.0 83405000.0 154978000.0 False True 68579289.92817748 68520726.10376059 124346530.37072948 1.0 0.999146042129071 1.8131790297181054 26.031269630858947 -6.906659333391498 0.918186213697016 0.9720560561379121 1.911194229777021 0.9895984890029811 0.039116166081795536 0.10666901697438985 0.15105829703854945 0.031505021724255566 0.08508078586371194 1.239768696954246e-07 6.906659333391498 0.9391381736391089 RPIMSNHTATHILNFALR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 RPIMSNHTATHILNFALR 18 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 271940200.0 37756000.0 107992000.0 126192200.0 False True 51715413.51753526 103220556.35821189 96388201.36993946 1.0 1.995934081107418 1.8638196006545882 25.624090996805286 -10.14117179724301 5.057541669498863 0.9999578433580599 1.9298768408826228 0.985086295791029 0.05393551079601654 2.5639110151092135e-05 4.353785390269551e-06 0.052225188157521266 0.0174076112560403 7.22483948477175e-11 10.14117179724301 0.9299189975245629 RPIMSNHTATHILNFALR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 RPIMSNHTATHILNFALR 18 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 143846810.0 57910100.0 41428710.0 44508000.0 False True 48154814.002416335 41205525.31627487 53814417.0182594 1.0 0.8556885987392089 1.1175293297895217 25.52117669468424 -6.757111418813512 1.6235867097641807 0.9158730399598096 1.1183432130880295 0.6789420977236212 0.06067491914592857 0.2878118872580509 1.4946417919020796 0.029496992607325863 0.07108272206813004 1.7493978207647922e-07 6.757111418813512 0.2024701731282199 RPIMSNHTATHILNFALR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 RPIMSNHTATHILNFALR 18 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 524251800.0 45205000.0 363878600.0 115168200.0 False True 58518763.62376743 343628436.0350037 94208769.32552318 1.0 5.87210690650065 1.6098899479697866 25.802395952951397 -6.61387694908042 2.1398831631133177 4.246560540132561 1.6257105885048342 0.06254389549163408 2.0984593908167484 0.6019311499442352 5.228918501392903 0.8083276054783077 2.3277108944166893 2.4328932357515224e-07 6.61387694908042 -2.6208499516277266 RPK(ub)EAENPEGEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPKEAENPEGEEK 13 2 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 7831200.0 2773500.0 3041200.0 2016500.0 True False 3798937.9010192812 2906829.72809647 1540244.2311211212 1.0 0.7651690561502854 0.40544074982322376 21.857164698641203 -6.964905552016193 0.3596694609552199 1.0311150660931823 0.127173597550526 0.9999111849546163 0.0023042641606876224 0.07799301780346589 0.014973034951788283 0.004829539219605668 0.03073141551887004 1.0841626661401983e-07 6.964905552016193 -0.9039414685426562 down RPK(ub)EAENPEGEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPKEAENPEGEEK 13 2 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 9442300.0 3678600.0 4686900.0 1076800.0 True False 3058918.8896114645 4661650.7394231865 1301953.90143933 1.0 1.5239536933309457 0.4256255064038984 21.54459042218083 -6.776975757387855 1.547591751998164 1.2978395279359496 0.4177262732004307 0.7565688404337281 0.22130798088975717 0.2552992488971763 1.2074987967435526 0.11265469046718189 0.26650448656595727 1.6711838983242603e-07 6.776975757387855 -0.8801132547355188 down RPK(ub)EEDPATGTGDPPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPKEEDPATGTGDPPR 16 2 P45974-2;P45974;F5H571 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 3934170.0 781170.0 1890800.0 1262200.0 True False 1024121.4348610406 1608700.0102806746 1131599.6518773383 1.0 1.570809823445355 1.1049467508029271 19.96595536189319 -10.15248765125983 4.645311662280854 0.999963300476338 1.3378782871240817 0.41223588681154755 0.19018780301524885 133075135.65418507 2.813916741511683 55606.52939943763 0.06510634366826794 7.039022424258898e-11 10.15248765125983 0.3379149866477438 RPK(ub)EEDPATGTGDPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPKEEDPATGTGDPPR 16 2 P45974-2;P45974;F5H571 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 6589800.0 1947600.0 1479600.0 3162600.0 True False 1885774.504062342 2070411.996012067 2334220.1840337124 1.0 1.0979106948110595 1.2378045089724816 20.846725741985757 -6.966053868412418 0.33949691970469664 0.9847378002931786 1.355622785701115 0.9999332296315193 0.000797387349304702 0.07760532995400996 0.013610068596297632 0.0019778450936991368 0.012112861787728912 1.0812998222224287e-07 6.966053868412418 0.37088498540793635 RPK(ub)EEDPATGTGDPPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPKEEDPATGTGDPPR 16 2 P45974-2;P45974;F5H571 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 6129800.0 1724000.0 2110700.0 2295100.0 True False 2231751.9851205624 1993237.689545583 1877415.349714662 1.0 0.8931268809593578 0.8412293849100089 21.08974527851743 -13.999999978471248 0.09510354546883422 1.5362843378779498 0.7217967353929025 0.9998179553092429 0.0008918334440193884 12.11946536848232 0.09081254892212934 1.292844158249926 0.10685926999781263 1.000000049571785e-14 13.999999978471248 -0.8144876024850474 RPK(ub)NFGIGQDIQPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPKNFGIGQDIQPK 14 2 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 18801900.0 5789600.0 5742000.0 7270300.0 True False 7590221.66656616 4885315.9821407 6518039.097642073 1.0 0.643632847201264 0.8587415999130965 22.85571058837545 -10.30684521604909 5.685718671379664 1.0000284963725656 0.751187223557178 0.6407903276993373 0.08781778055842727 3.172556434968516e-05 3.867691291291931e-06 0.08503892771098431 0.028343066800306054 4.933496040116901e-11 10.30684521604909 -0.2488412728153876 RPK(ub)NFGIGQDIQPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPKNFGIGQDIQPK 14 2 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 25212000.0 5296600.0 6239400.0 13676000.0 True False 5128462.332212262 8730824.958041154 10093845.32879435 1.0 1.7024254820401388 1.9682011244177695 22.29009489647655 -10.64610176729213 0.20203326245159497 1.8595090606885628e-13 2.1821529617327275 0.9993732710179879 0.010225257264505771 2.460719637402309 0.1057803245912819 1.368326677339756 0.16186086483187104 2.2589063835225967e-11 10.64610176729213 2.1821529617325415 RPK(ub)NFGIGQDIQPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPKNFGIGQDIQPK 14 2 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 28775300.0 8146200.0 4408100.0 16221000.0 True False 12358380.966993025 3621440.1143575036 13014912.240083128 1.0 0.2930351576011217 1.0531243756640598 23.558986416848278 -11.966560324971766 18.33377060535046 0.934918914246893 0.7057717899803712 0.0 0.35476545588142355 0.0 0.0 0.0 0.10310320867045145 1.0800395893119142e-12 11.966560324971766 -0.22914712426652184 RPK(ub)NFGIGQDIQPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPKNFGIGQDIQPK 14 2 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 16497100.0 5789600.0 3766100.0 6941400.0 True False 7930171.578057058 3599701.2491727346 5301984.282620454 1.0 0.4539247623762869 0.6685838043266491 22.918920649898343 -10.203447421408471 5.443686137631844 1.0000202316200155 0.5612542833514182 0.8477962505810375 0.08763418690902727 2.151875653841909e-05 3.148892345300688e-06 0.08485534315854124 0.028283812204731317 6.259686432802627e-11 10.203447421408471 -0.4387659482685973 RPK(ub)NFGIGQDIQPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPKNFGIGQDIQPK 14 2 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 23885500.0 5296600.0 10201000.0 8387900.0 True False 4404357.579164927 10146045.188260034 10141771.108732317 1.0 2.303637932636646 2.3026675119905256 22.070500171910826 -10.184463707831751 5.129243346895844 0.9999145108075108 2.3031527223145396 0.9999995840101451 0.0003961725731306583 3.8732698631596657e-07 6.158469975479888e-08 0.0003836172112707618 0.00012786414768620893 6.539375745417324e-11 10.184463707831751 1.3032382115070287 RPK(ub)NFGIGQDIQPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPKNFGIGQDIQPK 14 2 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 28804900.0 8146200.0 8044700.0 12614000.0 True False 10545416.485608552 7597005.3731403565 10318381.430569798 1.0 0.720408281978059 0.9784707360445563 23.330112738940727 -10.440347927252834 8.049604632369547 1.000004706879779 0.8494395091540607 0.3121705357554503 0.1053535557055567 8.899699510018014e-06 6.186591521404221e-07 0.1020113300313011 0.034002713892613036 3.627872977664422e-11 10.440347927252834 -0.1505651977257183 RPK(ub)VEYSEEELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPKVEYSEEELK 12 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 6705000.0 1633400.0 2989800.0 2081800.0 True False 2141403.2178681027 2543733.4941491196 1866395.306035686 1.0 1.18788160628691 0.871575838899596 21.030125044471898 -6.745796943289874 1.6653552552543944 1.1110344647475427 0.8711427542792237 0.6306568768794362 0.07893854935745793 0.30746004676254424 1.676327974760678 0.03746548835445563 0.09136267426828383 1.7955729603504897e-07 6.745796943289874 -0.23989171046831903 RPK(ub)VEYSEEELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPKVEYSEEELK 12 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 13608200.0 3395800.0 2206200.0 8006200.0 True False 3288002.187766941 3087147.1651810114 5909136.039148385 1.0 0.9389127466723673 1.797181297851142 21.64877982828278 -6.889809325938492 1.023540038103119 0.9536729958055571 1.8707169551524612 0.9807748902685842 0.05421249854124673 0.11929678546125408 0.22276724816388288 0.04036813392112948 0.10056674569429462 1.2888152731442504e-07 6.889809325938492 0.9170439593469041 RPK(ub)VEYSEEELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPKVEYSEEELK 12 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 22869300.0 5418500.0 5687800.0 11763000.0 True False 8220260.645411569 4672767.651015766 9438037.894093955 1.0 0.5684451932341145 1.1481433863489636 22.97075270847214 -6.7074030121616115 1.804779294952275 0.7339857460982046 1.1466621610792869 0.4526491140738237 0.18193040845543476 0.38030150831612247 2.4131096263207175 0.08027503193170726 0.20455690221780629 1.9615391828919893e-07 6.7074030121616115 0.4126764149810823 RPK(ub)VEYSEEELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPKVEYSEEELK 12 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 6679300.0 1633400.0 2314900.0 2731000.0 True False 2237312.120975266 2212620.0636493885 2085994.0467105284 1.0 0.9889635169387478 0.9323661312849024 21.09333510599479 -6.93924381031558 0.6665792890109229 1.000644339037666 0.917438143600747 0.9980628982396741 0.0013039111313820988 0.08811365843028272 0.05619724960336643 0.0012620890767706073 0.00488768876041474 1.1501545178240351e-07 6.93924381031558 -0.08320619543691898 RPK(ub)VEYSEEELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPKVEYSEEELK 12 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 13834100.0 3395800.0 6989100.0 3449200.0 True False 2823758.159447238 6951448.331072273 4170411.7727010907 1.0 2.4617718439574325 1.476901185304575 21.429185103717057 -10.504132868654949 5.56292585657678 0.9983095606186507 1.969336514630792 0.5636244888386261 0.4020717627230525 0.008440393330614929 0.0007523577964991168 0.389799079366131 0.1297681034172196 3.13232726916698e-11 10.504132868654949 0.9710269540121412 RPK(ub)VEYSEEELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPKVEYSEEELK 12 2 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 29537700.0 5418500.0 6647200.0 17472000.0 True False 7014355.064603121 6277277.476641587 14292275.277859159 1.0 0.8949186944240841 2.037575107935861 22.74187903056459 -6.884411873247359 1.054853378449953 0.9301301960782172 2.12574154639594 0.977074738299641 0.07807851591318912 0.12379527923978248 0.24926087880963935 0.05677090878519221 0.13896649776457579 1.3049327378745375e-07 6.884411873247359 1.1956113503177228 up RPLDPK(ub)SEAQLQEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPLDPKSEAQLQEIR 15 2 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A0A0MSW3;A0A494BZU9 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 1 20110100.0 2392000.0 2874100.0 14844000.0 True False 3628838.8786240583 2361194.3995542037 11910076.89364368 1.0 0.6506749069138872 3.28206274569005 21.79107657153399 -6.873451226741762 1.1156278387176914 0.7976280704283139 3.446658966947527 0.9680102877436907 0.2087005362849905 0.13359130099208044 0.3086624726007496 0.14485079785371816 0.34516270965723395 1.3382855023026128e-07 6.873451226741762 2.6490308965192133 up RPLDPK(ub)SEAQLQEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPLDPKSEAQLQEIR 15 2 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A0A0MSW3;A0A494BZU9 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 1 14376000.0 2392000.0 4046500.0 7937500.0 True False 3096491.1533691348 3821308.717840621 6492956.445627701 1.0 1.2340770661278488 2.096875503281527 21.562202893626438 -6.946754849683573 0.5934019671987616 0.9901232877176294 2.3844986021351193 0.9989213916681005 0.015491037220762 0.08481558898958913 0.04156122262818767 0.016004349301343 0.07235581903690039 1.1304338412966096e-07 6.946754849683573 1.39437531441749 up RPLEATFDLGIPQAVLPPLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPLEATFDLGIPQAVLPPLPK 21 1 Q9NR56;C9JP00;A0A0A0MQX8;Q86VM6 Q9NR56 MBNL1 Muscleblind-like protein 1 0 4667590.0 2601700.0 500190.0 1565700.0 False True 2519110.457598576 699918.4754563906 1155596.2000068226 1.0 0.27784350358483717 0.45873184977701703 21.264482951871088 -10.767399809659286 10.482723970420082 1.002302691502392 0.3682876766893621 0.942067060750277 0.07384735809779285 0.003976374866974436 8.82311421243236e-05 0.0715419682454732 0.02383413233951392 1.7084418066328387e-11 10.767399809659286 -0.6340150148130299 RPLEATFDLGIPQAVLPPLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPLEATFDLGIPQAVLPPLPK 21 1 Q9NR56;C9JP00;A0A0A0MQX8;Q86VM6 Q9NR56 MBNL1 Muscleblind-like protein 1 0 23311000.0 5146100.0 10782000.0 7382900.0 False True 7807009.930304049 8857867.859849507 5923666.578959972 1.0 1.1346044053903914 0.7587625264784659 22.896338674068197 -6.809847526195334 1.4150796414532283 1.0733723736975698 0.7522044942784633 0.8594469868594172 0.05829070528928081 0.20701188636223822 0.8170200811704734 0.03238940146687164 0.07493182754609622 1.549360478971123e-07 6.809847526195334 -0.3211678794191065 RPLEATFDLGIPQAVLPPLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPLEATFDLGIPQAVLPPLPK 21 1 Q9NR56;C9JP00;A0A0A0MQX8;Q86VM6 Q9NR56 MBNL1 Muscleblind-like protein 1 0 12497000.0 5146100.0 4511000.0 2839900.0 False True 6661727.8947963705 4259958.8845123025 2323067.3398347213 1.0 0.6394675603366891 0.34871843709637595 22.667464996160646 -7.643539727749874 0.22393136492788834 1.1767292211563745 1.7956976049341137e-14 0.9998766983441387 0.0029580546657647848 0.13113516210630535 0.026654580426880504 0.03976496262050066 0.0769328257032385 2.272271766239211e-08 7.643539727749874 -1.1767292211563565 down RPLEVLLGCPVPLGVKQK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPLEVLLGCPVPLGVKQK 18 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 37883100.0 6801900.0 21683000.0 9398200.0 True False 8917356.769693308 18447980.919671997 8425764.417900192 1.0 2.0687723275096097 0.9448724140471927 23.088184707679545 -6.6575267721417175 1.981415802735506 1.6893351791953717 0.9495487581166789 0.22527610894783712 0.45532587547923076 0.4903143692577518 3.6977520542833546 0.1858167607808344 0.504704504021738 2.2002560703754608e-07 6.6575267721417175 -0.7397864210786927 RPLEVLLGCPVPLGVKQK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPLEVLLGCPVPLGVKQK 18 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 106788000.0 21633000.0 30743000.0 54412000.0 True False 32818842.584144793 25256671.453844637 43657444.35037315 1.0 0.7695783722137252 1.3302554542695733 24.968021024709767 -6.7950834524594 1.4757182569360234 0.8720663494392523 1.337105035033469 0.8174714521909123 0.09830722371517807 0.22783833489486158 0.9799684079102985 0.05241856030837457 0.12229918567160418 1.6029373464423887e-07 6.7950834524594 0.4650386855942167 RPLEVLLGCPVPLGVKQK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPLEVLLGCPVPLGVKQK 18 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 36080900.0 6801900.0 15862000.0 13417000.0 True False 9316746.244435938 15161164.391380446 10248180.931788787 1.0 1.6273024931246634 1.0999742466860802 23.151394769202437 -10.277054122929098 4.578550328988741 0.9998219157059738 1.363638369907006 0.38801955639619023 0.2152808551274326 0.00039153595208585366 6.182279877009495e-05 0.20854612226440475 0.06948159722136765 5.283793996310868e-11 10.277054122929098 0.36381645420103226 RPLEVLLGCPVPLGVKQK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPLEVLLGCPVPLGVKQK 18 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 26709200.0 4374200.0 2188000.0 20147000.0 True False 3637341.1099164034 2176212.8097160025 24359644.550796974 1.0 0.5982976971236053 6.697102035436217 21.794452797429685 -6.891161137156512 1.0155132474734974 0.6813666409497975 7.233697281253086 0.9816302720717953 0.37748577687696966 0.11820512885252303 0.21639714531912851 0.28279669039122246 0.7080117556895809 1.284809865903347e-07 6.891161137156512 6.552330640303288 up RPLILQLIFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPLILQLIFSK 11 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 0 9190800.0 3359400.0 3582800.0 2248600.0 False True 4404205.932475876 3048260.205645019 2015936.44209427 1.0 0.6921248125950832 0.45772983212004065 22.070450497539746 -7.504011311895326 0.16346168949679782 1.26808655198984 6.346553296478833e-11 0.9999789276529805 0.0010193294671726396 0.1306401683891024 0.01479252897750523 0.03762850072889016 0.06735651107923062 3.1332041139336214e-08 7.504011311895326 -1.2680865519263746 down RPLILQLIFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPLILQLIFSK 11 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 0 7623900.0 3948700.0 1619500.0 2055700.0 False True 3823350.679909098 2266174.7955809324 1517250.500321917 1.0 0.5927195764409483 0.3968379119118601 21.866406100379095 -13.036695399987913 0.10626163659550282 2.645269879565691 2.858694837952636e-20 0.9997942261126573 0.0036038538039758388 8.569393162407835 0.0883843093336651 3.3053619761477115 0.32721968782676464 9.189769109966182e-14 13.036695399987913 -2.645269879565691 RPLILQLIFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPLILQLIFSK 11 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 0 281057000.0 62072000.0 95698000.0 123287000.0 False True 94167762.07105048 78619944.20811324 98919270.41138834 1.0 0.8348923504074965 1.0504579086922847 26.488729908120938 -6.702057940738763 1.8237088364955094 0.8976819575505617 1.049838517384439 0.42730017762868555 0.06966802662880203 0.39124023526211665 2.5312260451433835 0.030461109313696305 0.07813436501839376 1.9858299631947702e-07 6.702057940738763 0.15215655983387721 RPLILQLIFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPLILQLIFSK 11 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 0 21960200.0 3359400.0 6786600.0 11814200.0 False True 4601460.964371434 6486745.571714942 9023929.281086618 1.0 1.4097143541890376 1.9611009092455267 22.133660559062637 -6.966997311665117 0.3219351080830879 0.9261820863382887 2.46246867102416 0.9999485948314158 0.0028233384808397026 0.07728955992769646 0.01250384983314706 0.008293411221637148 0.048418986787019606 1.0789534010599974e-07 6.966997311665117 1.5362865846858713 RPLILQLIFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPLILQLIFSK 11 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 0 8025100.0 3948700.0 2209300.0 1867100.0 False True 3283519.0070702937 2197398.062388286 2257501.9775049905 1.0 0.6692204484447024 0.6875251742548119 21.64681137581337 -10.421518524068933 6.946078821565085 1.0000308442021915 0.6783728113497649 0.9975765798538903 0.007472873019386932 3.5698152686960993e-06 2.9730732341413324e-07 0.007236270275800906 0.0024118593960340247 3.788623736941588e-11 10.421518524068933 -0.32165803285242656 RPLILQLIFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPLILQLIFSK 11 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 0 218343000.0 62072000.0 78561000.0 77710000.0 False True 80353427.62204394 74189011.28933091 63567577.37193431 1.0 0.9232837165116539 0.7910997608084034 26.259856230213387 -6.962852700687363 0.39318238873146805 1.007835885087955 0.7017738951724438 0.9998617820847333 0.001014337586536762 0.07869755059087755 0.01747904214108839 0.0017039750951221367 0.01110433665613528 1.0892994875236887e-07 6.962852700687363 -0.30606198991551115 RPLILQLVHVSQEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPLILQLVHVSQEDK 15 1 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;F8W1W3;F8VZ52;B4DDQ3;B4DPZ9;F8VYL3;F8VR28;H0YHY4 O00429-9 DNM1L Dynamin-1-like protein 0 10099300.0 5148100.0 1863800.0 3087400.0 False True 6749208.954271314 1585728.3050354973 2767945.464432022 1.0 0.23495024613691226 0.41011405680073015 22.68628698932067 -10.594119890794733 9.625876050148076 1.000083933835019 0.32253215151638176 0.9522552071574425 0.07151032625463943 0.0001288251243418816 5.431965006471684e-06 0.0692479139529206 0.023079858555506448 2.5461272748279324e-11 10.594119890794733 -0.6775517823186372 RPLILQLVHVSQEDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPLILQLVHVSQEDK 15 1 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;F8W1W3;F8VZ52;B4DDQ3;B4DPZ9;F8VYL3;F8VR28;H0YHY4 O00429-9 DNM1L Dynamin-1-like protein 0 8315800.0 2911500.0 1849700.0 3554600.0 False True 2819076.0261745253 2588294.856058073 2623543.624285782 1.0 0.9181358828305098 0.9306395428596937 21.42679095503881 -9.804344307020948 5.5732279144623424 1.0000000164032783 0.924387712847461 0.979902853178158 0.005104597834168935 1.0403960386448866e-09 2.1804423467651768e-10 0.004942506666934904 0.001647501866341116 1.5691183200243168e-10 9.804344307020948 -0.07561230355581727 RPLILQLVHVSQEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPLILQLVHVSQEDK 15 1 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;F8W1W3;F8VZ52;B4DDQ3;B4DPZ9;F8VYL3;F8VR28;H0YHY4 O00429-9 DNM1L Dynamin-1-like protein 0 11947000.0 5148100.0 3393800.0 3405100.0 False True 7051491.692171392 3243850.6942041963 2600885.5102358228 1.0 0.4600233306387553 0.3688418881813817 22.749497050843562 -13.999999999999998 0.2502559564344499 4.760135665254785 0.33226842711222626 0.9995431702147276 0.005953344841413737 14.00816099808175 0.15829789020505758 26.482535961823913 0.0420199490255803 1.0000000000000041e-14 13.999999999999998 -4.427867238142558 RPLILQLVHVSQEDKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPLILQLVHVSQEDKR 16 2 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;F8W1W3;F8VZ52;B4DDQ3;B4DPZ9;F8VYL3;F8VR28;H0YHY4 O00429-9 DNM1L Dynamin-1-like protein 0 8374100.0 2927500.0 2827900.0 2618700.0 False True 3837980.849950332 2405988.343067866 2347742.044344153 1.0 0.626889095368728 0.6117128084092799 21.87191608238154 RPLILQLVHVSQEDKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPLILQLVHVSQEDKR 16 2 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;F8W1W3;F8VZ52;B4DDQ3;B4DPZ9;F8VYL3;F8VR28;H0YHY4 O00429-9 DNM1L Dynamin-1-like protein 0 7917400.0 2927500.0 2177800.0 2812100.0 False True 4009875.8627128038 2081577.5949784613 2147939.8970174585 1.0 0.5191127272379475 0.535662442069793 21.93512614390443 -9.871303391496754 6.8203071908206425 1.0000000094721346 0.5273875846721584 0.9990811743013955 0.006756392787798644 9.677701601495027e-10 1.715133627217603e-10 0.006541849284361214 0.0021806163956267373 1.344920484880792e-10 9.871303391496754 -0.4726124247999762 RPLLGLVLTPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPLLGLVLTPTR 12 1 G3V529;Q9GZR7-2;Q9GZR7;A0A087WXU8;A0A1W2PRR2;F5GYL3 G3V529 DDX24 ATP-dependent RNA helicase DDX24 0 15027200.0 5038800.0 4546900.0 5441500.0 False True 6605915.595808605 3868520.243677383 4878465.778553744 1.0 0.5856145431425017 0.738499562672143 22.65532710566177 -10.087295827302976 4.813500307373867 1.0000126911674478 0.662057052905004 0.8669278126916029 0.06241504787540754 9.151895583756409e-06 1.735334040546882e-06 0.06043555244524282 0.020144370079043235 8.179074663264831e-11 10.087295827302976 -0.3379556382624438 RPLLGLVLTPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPLLGLVLTPTR 12 1 G3V529;Q9GZR7-2;Q9GZR7;A0A087WXU8;A0A1W2PRR2;F5GYL3 G3V529 DDX24 ATP-dependent RNA helicase DDX24 0 8499800.0 4532600.0 2498400.0 1468800.0 False True 4388715.0940198 3496024.148983882 1084077.2169445115 1.0 0.7965940085169058 0.24701471700036048 22.065367185890803 -6.953777180322318 0.5157155778544794 1.0096577138886453 0.009604066181410707 0.9994653188451414 0.007354306961326677 0.08200360294626274 0.029953109577623697 0.008389484715273357 0.04537770203412887 1.1123022601181873e-07 6.953777180322318 -1.0000536477072346 down RPLLGLVLTPTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPLLGLVLTPTR 12 1 G3V529;Q9GZR7-2;Q9GZR7;A0A087WXU8;A0A1W2PRR2;F5GYL3 G3V529 DDX24 ATP-dependent RNA helicase DDX24 0 23456300.0 2614000.0 7972300.0 12870000.0 False True 3965629.108998035 6549580.7771358015 10326238.858878601 1.0 1.6515868219432739 2.603934602822111 21.91911832313132 -6.965684800405985 0.3460976996344176 0.9037349552767475 3.383730634888154 0.9999265740766692 0.005643724435972283 0.07772934178411418 0.01404482074833777 0.013207994869989673 0.08207326324171493 1.0822191127101217e-07 6.965684800405985 2.4799956796114064 RPLLGLVLTPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPLLGLVLTPTR 12 1 G3V529;Q9GZR7-2;Q9GZR7;A0A087WXU8;A0A1W2PRR2;F5GYL3 G3V529 DDX24 ATP-dependent RNA helicase DDX24 0 16717100.0 5038800.0 4623800.0 7054500.0 False True 6901780.528449951 4419505.227138126 5388372.3919880735 1.0 0.6403427650184479 0.7807220716127626 22.71853716718466 -10.193002591928115 4.904360726878368 1.0000319001758962 0.7105324183150049 0.8500600991904604 0.057309611935707806 1.9991866600344306e-05 3.2895535146544405e-06 0.05549590091668485 0.018496597716754368 6.412057497712388e-11 10.193002591928115 -0.28949948186089125 RPLLGLVLTPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPLLGLVLTPTR 12 1 G3V529;Q9GZR7-2;Q9GZR7;A0A087WXU8;A0A1W2PRR2;F5GYL3 G3V529 DDX24 ATP-dependent RNA helicase DDX24 0 8823300.0 4532600.0 1599800.0 2690900.0 False True 3769057.7282262067 1591181.559864562 3253554.7486841474 1.0 0.42216959107532787 0.8632276243259703 21.84577246132508 -9.867257709258851 6.471862265516194 1.0000000166756449 0.6426986077006311 0.46667161075133845 0.18006118807004848 4.344235638093594e-08 7.626938355706508e-09 0.17434350346710248 0.05811449855778392 1.35750766588455e-10 9.867257709258851 -0.3573014089750137 RPLLGLVLTPTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPLLGLVLTPTR 12 1 G3V529;Q9GZR7-2;Q9GZR7;A0A087WXU8;A0A1W2PRR2;F5GYL3 G3V529 DDX24 ATP-dependent RNA helicase DDX24 0 19203400.0 2614000.0 7802300.0 8787100.0 False True 3383874.5296433643 7368095.146227087 7187937.963259861 1.0 2.177413814159247 2.1241739019257952 21.690244645223768 -10.055829396612415 4.894907617793197 0.9999724976593954 2.1507938580542816 0.9983973292996281 0.021735103194381884 6.523615366796836e-06 1.2583027550994584e-06 0.021045423763720532 0.007014974385868577 8.793678900381795e-11 10.055829396612415 1.150821360394886 RPLQEGDIVNVDITLYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPLQEGDIVNVDITLYR 17 1 P53582 P53582 METAP1 Methionine aminopeptidase 1 0 22129700.0 5993100.0 10936000.0 5200600.0 False True 9091970.854298439 8984385.356642 4172699.1304960432 1.0 0.9881669772835254 0.45894330254295784 23.116161628707992 -6.911720297127837 0.8839230268801137 1.0155080040466495 0.3879687816004148 0.991555001432552 0.023186793793140516 0.10329196925707869 0.13267273185525433 0.01914625935244749 0.05350509507629496 1.2254051547024694e-07 6.911720297127837 -0.6275392224462347 down RPLTSCTIFLGYTSNLISSGIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPLTSCTIFLGYTSNLISSGIR 22 1 P49366;P49366-3;A0A087WZK0;P49366-2;Q5J8M5;M0R253;M0QX43;B4E3M2;M0R264;M0R0J4;M0QYZ7;M0QZT3 P49366 DHPS Deoxyhypusine synthase 0 52133000.0 11325000.0 19971000.0 20837000.0 False True 17180852.968401954 16407019.0158648 16718557.816818446 1.0 0.9549595148762204 0.9730924214045872 24.034298327156844 -10.148333025020513 4.685078050826239 1.0000036801274863 0.9640259681400348 0.8399450783165392 0.00740272809261103 2.845889680809706e-07 5.172593564276789e-08 0.0071683938920501025 0.0023892202180864548 7.10668351057797e-11 10.148333025020513 -0.03597771198745148 RPMSAYMLWLNASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPMSAYMLWLNASR 14 1 Q08945;A0A0U1RRK2 Q08945 SSRP1 FACT complex subunit SSRP1 0 15039100.0 3288900.0 7919500.0 3830700.0 False True 4311779.749752911 6737941.469969211 3434335.91066909 1.0 1.5626822010923291 0.7965007746200156 22.039852054915823 -6.709894009381409 1.7956793550634311 1.345962108976134 0.7983133831451816 0.4645710972986081 0.23711481623034936 0.375280177345897 2.3587972583458066 0.10508723504995715 0.2669956159848681 1.9503205221206926e-07 6.709894009381409 -0.5476487258309524 RPMSAYMLWLNASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPMSAYMLWLNASR 14 1 Q08945;A0A0U1RRK2 Q08945 SSRP1 FACT complex subunit SSRP1 0 19787800.0 7590200.0 4939100.0 7258500.0 False True 7349253.255665431 6911308.387066247 5357281.099667583 1.0 0.9404096098795373 0.7289558426276485 22.809166237085567 -6.947628951234424 0.5842989394635927 1.0024889921536884 0.6563401726155679 0.9990017992310745 0.003674375651623559 0.08445213431502482 0.040012746243441165 0.0038321120757758807 0.01768508977443971 1.1281609129113753e-07 6.947628951234424 -0.3461488195381205 RPMSAYMLWLNASR ddPTM_RPMI8226_Bortezomib_8h_R1 2 RPMSAYMLWLNASR 14 1 Q08945;A0A0U1RRK2 Q08945 SSRP1 FACT complex subunit SSRP1 0 129094600.0 25572500.0 40621800.0 62900300.0 False True 38795352.10017293 33372522.410427965 50468028.134819105 1.0 0.8602196037364798 1.3008782084128616 25.209380484054524 -6.821393000595239 1.3656984625800115 0.9247590555504248 1.3107982560638631 0.8875644440641373 0.06165143710168242 0.1916937700070411 0.7021310763522088 0.03546922167099626 0.08172761259935586 1.5087142745871783e-07 6.821393000595239 0.3860392005134383 RPMSAYMLWLNASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPMSAYMLWLNASR 14 1 Q08945;A0A0U1RRK2 Q08945 SSRP1 FACT complex subunit SSRP1 0 29624900.0 3288900.0 10423000.0 15913000.0 False True 4504895.209180577 9962477.395748224 12154677.138522398 1.0 2.2114781661170673 2.698104300795331 22.103062116438714 -9.759017017591807 0.24146530631078703 9.691062972682768e-16 3.005635808327995 0.9991488844713019 0.0208298769611792 1.1840502508289392 0.10347306154716915 1.068315031062708 0.2257149929998195 1.7417386229788624e-10 9.759017017591807 3.005635808327994 RPMSAYMLWLNASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPMSAYMLWLNASR 14 1 Q08945;A0A0U1RRK2 Q08945 SSRP1 FACT complex subunit SSRP1 0 19760900.0 7590200.0 4919400.0 7251300.0 False True 6311587.602873095 4892898.215775556 8767513.303776953 1.0 0.7752246381795068 1.3891137785659344 22.589571512519843 -6.807617400808453 1.42461835917522 0.8771510346071927 1.3992688065686976 0.8534938783912116 0.09706628432942681 0.21006675814222378 0.840726486376655 0.05358296057109671 0.12408224572257895 1.55733699025544e-07 6.807617400808453 0.5221177719615049 RPMSAYMLWLNASR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 RPMSAYMLWLNASR 14 1 Q08945;A0A0U1RRK2 Q08945 SSRP1 FACT complex subunit SSRP1 0 169651900.0 25572500.0 79635000.0 64444400.0 False True 33104105.35933617 75203242.24520895 52716180.45538382 1.0 2.271719517228995 1.5924363423558452 24.980506806146973 -10.287186961942394 5.385609571292407 0.9998649422518519 1.9320779297924722 0.7151314957226427 0.2773161948830116 0.0004497726912629994 5.9528869273543226e-05 0.26854838940038833 0.08950341703459977 5.1619410204957785e-11 10.287186961942394 0.9322129875406203 RPNKPLFTALVTQCQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPNKPLFTALVTQCQK 16 2 Q8NCW5-2;Q8NCW5;Q5T3I4;Q5T3I3 Q8NCW5-2 APOA1BP NAD(P)H-hydrate epimerase 0 56365000.0 28128000.0 28237000.0 0.0 False True 36876080.39193948 24024149.666963898 0.0 1.0 0.6514832761948092 0.0 25.136181982136364 -7.530981372132579 0.703075901738455 0.9940756776320195 6.930633766585955e-15 0.9870615063002683 0.04714227192229675 0.1200430188168849 0.1436173707857772 0.04192051913653258 0.07612268718197591 2.9445479293756397e-08 7.530981372132579 -0.9940756776320127 down RPNKPLFTALVTQCQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPNKPLFTALVTQCQK 16 2 Q8NCW5-2;Q8NCW5;Q5T3I4;Q5T3I3 Q8NCW5-2 APOA1BP NAD(P)H-hydrate epimerase 0 22710300.0 17145000.0 5565300.0 0.0 False True 16600741.359698525 7787553.3126560915 0.0 1.0 0.4691087671278264 0.0 23.98474433542699 -8.02801068712631 0.5745172969120622 1.0158846751854613 1.8667412245782196e-15 0.989801532601333 0.04125417817049831 0.11229064314959687 0.16593512888370426 0.046981344147091327 0.07582254551677084 9.375389356672632e-09 8.02801068712631 -1.0158846751854596 RPNPDILDHER ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPNPDILDHER 11 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 3261440.0 1162500.0 948240.0 1150700.0 False True 1524048.7576660141 806766.2882105706 1031636.6022938163 1.0 0.5293572690194525 0.6769052480143113 20.539477627875716 -10.89148440151591 11.130066049715623 1.0245958089855638 0.603131258516932 0.9060716777180046 0.060236210186049084 0.027945018240582868 0.0002724570653405156 0.044333197758231975 0.01944115324076813 1.2838538816149053e-11 10.89148440151591 -0.42146455046863185 RPNPDILDHER ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPNPDILDHER 11 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 5637300.0 2011400.0 1412300.0 2213600.0 False True 1947549.2079846973 1976238.7550472033 1633791.7534234563 1.0 1.0147311025286974 0.838896263429506 20.893228350098216 -6.886553338952791 1.042533695883655 1.010243074334855 0.8247546854721157 0.97859983409579 0.011651039109190735 0.12198512471863275 0.2385285794354351 0.008551309699861549 0.021070905649597252 1.2985140738121447e-07 6.886553338952791 -0.18548838886273922 RPNPDILDHER ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPNPDILDHER 11 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 7837800.0 1359100.0 3915300.0 2563400.0 False True 2061854.0635192113 3216584.1246214733 2056742.8664218672 1.0 1.5600445160174659 0.9975210674762208 20.975510792773193 -10.451777326936634 3.3327501435224556 0.995854155838535 1.2787827916091088 0.24669495351940496 0.2296492370120619 83365557.52832241 132247316.18080935 3337602.3555298494 0.08404300490191025 3.533643015965005e-11 10.451777326936634 0.2829286357705738 RPNPDILDHER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPNPDILDHER 11 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 3597800.0 1162500.0 1053600.0 1381700.0 False True 1592307.6653812567 1007048.4682107196 1055370.9170047368 1.0 0.6324459086049776 0.6627933407279317 20.602687689398607 -10.064902316889372 5.240992525915868 1.0000044276329831 0.6476196246658347 0.9944681207295055 0.012389287286330878 17188092.00459824 5.744079305456916 918.3972658470491 0.004241182573502612 8.611874318437055e-11 10.064902316889372 -0.35238480296714847 RPNPDILDHER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPNPDILDHER 11 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 5384690.0 2011400.0 2413800.0 959490.0 False True 1672568.2201284477 2400796.3802982112 1160114.9228194866 1.0 1.4353951913027727 0.6936129174631774 20.673633625532492 -6.747658266026735 1.658828062076767 1.2567383458397283 0.6924256592283715 0.6387177026805069 0.18293741928661866 0.3041398892701838 1.6459226896208168 0.0871508355200234 0.21207524194461874 1.7878938643158176e-07 6.747658266026735 -0.5643126866113568 RPNPDILDHER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPNPDILDHER 11 1 Q9UQ35;Q9UQ35-2;I3L4D8;I3L0N7 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 4620800.0 1359100.0 1362700.0 1899000.0 False True 1759381.7418662154 1286864.5470904273 1553401.485385446 1.0 0.7314299770585441 0.8829246367748017 20.746637114865642 -10.149272997483497 4.996475871598302 1.0000108273173807 0.8071773071393944 0.6835476021147102 0.06184743584500336 7.459921509311131e-06 1.2701151508946737e-06 0.05988688377895639 0.01996117408590531 7.091318675850712e-11 10.149272997483497 -0.19283352017798627 RPNQALLENIALYLTHMLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPNQALLENIALYLTHMLK 19 1 B4DKY1;P49589-2;P49589;P49589-3 B4DKY1 CARS Cysteine--tRNA ligase, cytoplasmic 0 412614000.0 98204000.0 167340000.0 147070000.0 False True 148982647.67407915 137476869.56661233 118001550.036929 1.0 0.9227710187253663 0.79204895254026 27.150569065810593 -6.9631716343443 0.3881548049116349 1.0081953816440425 0.7019414653814882 0.9998703497151995 0.000977242312818941 0.07858700036287823 0.017082504497394683 0.0016896532266529834 0.011004825273566186 1.0884998302655104e-07 6.9631716343443 -0.3062539162625544 RPNQALLENIALYLTHMLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPNQALLENIALYLTHMLK 19 1 B4DKY1;P49589-2;P49589;P49589-3 B4DKY1 CARS Cysteine--tRNA ligase, cytoplasmic 0 347934000.0 98204000.0 125190000.0 124540000.0 False True 127127013.89024362 118223066.44914551 101874997.88831152 1.0 0.9299602250644743 0.8013638861703014 26.921695387903043 -6.961682574183884 0.41103497019485924 1.0062637007639739 0.7202800279668657 0.9998275941408682 0.0010800733627771885 0.07910548484631721 0.018950337500752843 0.0016564120291170821 0.010733261545449423 1.0922383617414247e-07 6.961682574183884 -0.2859836727971081 RPPGDIMFLLVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPPGDIMFLLVQR 13 1 A0A087X1B2;B9A018;Q53GS9;Q53GS9-2;Q53GS9-3 A0A087X1B2 USP39 U4/U6.U5 tri-snRNP-associated protein 2 0 1607890.0 328280.0 518430.0 761180.0 False True 449653.9874334276 495524.0483812488 581404.9609941851 1.0 1.1020119074438595 1.2930052379003167 18.778455736700582 -6.9613149183362735 0.41648981184267414 0.9912318551933127 1.410948708502845 0.9998158944517386 0.0016478035612852411 0.07923471495290596 0.019420317680462033 0.0024656846046755445 0.015914635076797128 1.093163397312437e-07 6.9613149183362735 0.41971685330953223 RPPSAFFLFCSEHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPPSAFFLFCSEHR 14 1 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 4083200.0 1473500.0 925400.0 1684300.0 False True 2018292.7698402428 884512.7681114278 1286503.0292473622 1.0 0.4382479991648789 0.6374214130238374 20.94470403363985 -10.098369158000656 5.4143797042736885 1.0000060677208666 0.5378347060941243 0.8777373213080516 0.08131220571459229 5.955776221256943e-06 9.916482355691283e-07 0.07873123716614 0.026243401547881795 7.973166658578226e-11 10.098369158000656 -0.4621713616267423 RPPSAFFLFCSEHRPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPPSAFFLFCSEHRPK 16 2 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 375102000.0 90212000.0 159220000.0 125670000.0 False True 118268805.61425076 135464996.63469893 112666873.91176136 1.0 1.145399210984981 0.9526339031379006 26.817494360078452 -6.704970158528362 1.8134140865240624 1.0898472952832416 0.9531566200576169 0.4410128034383598 0.06132131137817719 0.38530206962887237 2.46668621116661 0.026944336511929567 0.06886486419644008 1.972558270923252e-07 6.704970158528362 -0.13669067522562472 RPPSAFFLFCSEHRPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPPSAFFLFCSEHRPK 16 2 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 134296590.0 49225000.0 33479590.0 51592000.0 False True 47662379.31940276 46848164.88075534 38078507.47317627 1.0 0.982917041694644 0.798921665618044 25.50634763728027 -6.925012654821659 0.7866478675117169 1.00337446437469 0.7655360840592224 0.9954640159219932 0.006130861325273893 0.09531138609951635 0.09098040497556603 0.005427844060059999 0.01712756420360498 1.1884675964084647e-07 6.925012654821659 -0.23783838031546767 RPPSAFFLFCSEHRPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPPSAFFLFCSEHRPK 16 2 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 480380000.0 72920000.0 142350000.0 265110000.0 False True 110624971.16608134 116946530.31437354 212710892.29815906 1.0 1.057144052393032 1.922810827031232 26.72110183826238 -6.920304976611368 0.8224627038030824 0.9811090139071114 2.063390974856437 0.9942652260557694 0.03197197212869626 0.09799255924421359 0.10468706842210189 0.027591726042879332 0.0828927084270369 1.201420459303237e-07 6.920304976611368 1.0822819609493255 RPPSAFFLFCSEHRPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPPSAFFLFCSEHRPK 16 2 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 318917000.0 90212000.0 133380000.0 95325000.0 False True 123565814.28763354 127486830.57132293 72811198.28000036 1.0 1.031732209319336 0.5892503416075274 26.880704421601344 -6.8896708593139735 1.0243510056173546 1.023963093965045 0.5514405717242806 0.980685951149119 0.028006991998273046 0.1194096727197213 0.22342226828232106 0.02084190000771706 0.05189688729850218 1.28922625315881e-07 6.8896708593139735 -0.4725225222407644 RPPSAFFLFCSEHRPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPPSAFFLFCSEHRPK 16 2 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 97762000.0 49225000.0 19227000.0 29310000.0 False True 40932768.5372491 19123420.334739294 35438585.48587177 1.0 0.46719098214275073 0.8657754349946403 25.286752912714547 -10.361691433416812 6.114389343695058 1.0000417108036583 0.6664832085687028 0.48281419569975803 0.1627214214822586 9.253467016429508e-05 9.660027942960682e-06 0.1575739879701513 0.0525181129559987 4.348190537386545e-11 10.361691433416812 -0.33355850223495553 RPPSAFFLFCSEHRPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPPSAFFLFCSEHRPK 16 2 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 549370000.0 72920000.0 270540000.0 205910000.0 False True 94396377.4680926 255484211.17622665 168436492.81501707 1.0 2.7065044022752267 1.7843533547879116 26.49222816035483 -9.769150544396 6.3107850946908615 0.9999999787453168 2.245428878532542 0.7086289406668784 0.37646658868963645 1.1286816215086096e-07 2.323874054842292e-08 0.36451221796135824 0.12150406903269464 1.7015685722413449e-10 9.769150544396 1.2454288997872252 RPPSAFFLFCSEYRPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPPSAFFLFCSEYRPK 16 2 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 229122000.0 78718000.0 90473000.0 59931000.0 False True 103200060.3061964 76974781.06099193 53729915.01874571 1.0 0.7458792255799696 0.520638407180462 26.62086857291651 -6.9725482666945195 0.1875819462053249 1.1575642129634443 0.102815539066338 0.9999960384642879 0.00038970350031053387 0.07548415214975389 0.005967301442259211 0.008118442137052335 0.02472063735895313 1.0652504670996182e-07 6.9725482666945195 -1.0547486738971061 RPPSAFFLFCSEYRPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPPSAFFLFCSEYRPK 16 2 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 108305000.0 56650000.0 23161000.0 28494000.0 False True 54851676.75864229 32409308.083019376 21030566.598323047 1.0 0.590853552674906 0.3834079073072187 25.709032387199233 -11.204870326938167 0.12184572368689668 2.058574281251755 5.820171382460277e-11 0.999793292177964 0.0036830775181335026 3.6778619645850874 0.07528596394705982 1.3312010808225903 0.26223113339877124 6.239211000687965e-12 11.204870326938167 -2.058574281193553 RPPSAFFLFCSEYRPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPPSAFFLFCSEYRPK 16 2 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 1391240000.0 291860000.0 380230000.0 719150000.0 False True 442772957.82408786 312374985.7494507 577009687.2853574 1.0 0.7054969826625143 1.3031728272678325 28.721991871903935 -6.772717734808937 1.5639752714753694 0.8316667634309949 1.306890795122908 0.7408595237543578 0.12421468286313724 0.26206520678074413 1.2654154791429784 0.06258766763087992 0.14862091271735112 1.6876495393185412e-07 6.772717734808937 0.4752240316919132 RPPSAFFLFCSEYRPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPPSAFFLFCSEYRPK 16 2 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 219577000.0 78718000.0 75107000.0 65752000.0 False True 107822171.87396283 71788524.39436458 50222731.8049472 1.0 0.665804844649955 0.46579224784726403 26.684078634439402 -9.469816106868738 0.11707363791356722 1.661647749442773 5.63848085695854e-13 0.9999116026412836 0.0020719147695146193 0.925039332424685 0.04563832726895121 0.4153038987320256 0.22030604122554043 3.389876631592681e-10 9.469816106868738 -1.6616477494422093 RPPSAFFLFCSEYRPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPPSAFFLFCSEYRPK 16 2 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 121709000.0 56650000.0 18359000.0 46700000.0 False True 47106985.02052131 18260096.42302381 56464754.0835965 1.0 0.38763033582109163 1.1986492886139632 25.48943766263351 -6.704705910902513 1.8137920073074036 0.6215201353339085 1.1964870276772817 0.4400908806584546 0.2582720558710032 0.38580226812994356 2.4706143175645514 0.11345378444744512 0.290122206504006 1.973758844427937e-07 6.704705910902513 0.5749668923433732 RPPSAFFLFCSEYRPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPPSAFFLFCSEYRPK 16 2 Q5T7C4;P09429 Q5T7C4 HMGB1 High mobility group protein B1 0 1119420000.0 291860000.0 420200000.0 407360000.0 False True 377818523.42070067 396815500.6145139 333224659.86656946 1.0 1.0502806930211308 0.881970150244656 28.493118193996384 -6.826657868861604 1.3429435082760772 1.0269348418591246 0.8777479981021723 0.8989795223834288 0.02242138795378806 0.18498171855030995 0.6536529609716747 0.013113556028385388 0.03018287500798089 1.4905348378801768e-07 6.826657868861604 -0.14918684375695235 RPPSGFFLFCSEFRPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPPSGFFLFCSEFRPK 16 2 E9PES6;E7ES08;E7EQU1;O15347 E9PES6 HMGB3 High mobility group protein B3 0 60505000.0 13976000.0 17773000.0 28756000.0 False True 21202613.782462317 14601269.288917203 23072363.99579745 1.0 0.6886542121044813 1.0881848923212332 24.337738790252644 -6.698727531203522 1.8351859499281813 0.8064306516569151 1.0869777469789 0.4116636349952032 0.1314531546840701 0.3981635046431996 2.606106193903044 0.05716103921616961 0.14724655417256174 2.0011169418143595e-07 6.698727531203522 0.28054709532198485 RPPSGFFLFCSEFRPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPPSGFFLFCSEFRPK 16 2 E9PES6;E7ES08;E7EQU1;O15347 E9PES6 HMGB3 High mobility group protein B3 0 58747000.0 13976000.0 23566000.0 21205000.0 False True 18092207.50814676 22254531.38382113 17345907.58167375 1.0 1.2300616922396073 0.9587502008178406 24.108865112345093 -6.68193816160053 1.8944274881150196 1.145299440559783 0.9597508647068963 0.3333492228910764 0.09746292624088163 0.4341867242191503 3.014181389620706 0.04125125242960855 0.10855083576946842 2.079992832406552e-07 6.68193816160053 -0.18554857585288664 RPQYSNPPVQGEVMEGADNQGAGEQGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPQYSNPPVQGEVMEGADNQGAGEQGR 27 1 P67809;H0Y449;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 0 15506200.0 4113900.0 1407800.0 9984500.0 False True 3983306.496335007 1969941.881580014 7369259.921420534 1.0 0.49454941099625005 1.8500358755222335 21.925535061762975 -6.805728942381584 1.4324370740914518 0.7231079819617056 1.8714945696250205 0.8483630962485436 0.21779609225751878 0.21269113616161106 0.8608990905016134 0.11958231515391668 0.2771885911628338 1.5641235595498865e-07 6.805728942381584 1.1483865876633148 RPQYSNPPVQGEVMEGADNQGAGEQGRPVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPQYSNPPVQGEVMEGADNQGAGEQGRPVR 30 2 P67809;H0Y449;C9J5V9 P67809 YBX1 Nuclease-sensitive element-binding protein 1 0 49251900.0 12274000.0 3174900.0 33803000.0 False True 11884368.588447928 4442654.1268847715 24948980.23173699 1.0 0.3738233204247136 2.0993105393910767 23.502561919741503 -6.808531082295189 1.4207753270067154 0.6581393886486111 2.128469467346524 0.855928413943788 0.27070760080868206 0.20881805988685195 0.8310657482028346 0.14983266906599002 0.34681792747707085 1.5540640630020693e-07 6.808531082295189 1.470330078697913 up RPRPPNAPSQDGK(ub)EAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPRPPNAPSQDGKEAK 16 3 P16989;P16989-2 P16989;P16989-2 YBX3 Y-box-binding protein 3 1 2998830.0 1284500.0 1012800.0 701530.0 True False 1948680.4095286806 832057.9269574826 562872.2880084784 1.0 0.4269853193416816 0.28884792255114733 20.8940660722367 -13.999999999999917 0.19983327457818156 4.18329216996891 0.1989876826219768 0.9994869232161842 0.00697407003690578 12.527595783177953 0.14174566462304447 15.586011323584268 0.0880680489245567 1.0000000000001922e-14 13.999999999999917 -3.984304487346933 RPSSVK(ub)VFSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPSSVKVFSGK 11 2 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 15343800.0 6274600.0 6123300.0 2945900.0 True False 8226061.363312829 5209727.508436461 2641086.5270681796 1.0 0.6333197964789289 0.32106331455866405 22.971770403163067 -7.5950974388639345 0.24910498099981712 1.14130832232591 4.5037807165501897e-13 0.9998281628953699 0.0036372753922058465 0.12954983917046656 0.028400048343313875 0.03301300432559553 0.07244345469123105 2.540402673620826e-08 7.5950974388639345 -1.1413083223254596 down RPSSVK(ub)VFSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPSSVKVFSGK 11 2 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 16465900.0 5945900.0 7529800.0 2990200.0 True False 5757150.6591211045 10536488.407388255 2206976.9159228452 1.0 1.8301567965214187 0.3833453467864893 22.45692353602067 -6.751059051904234 1.6456438832785836 1.4875000106743375 0.38018130720289817 0.6536748990266938 0.3488581006465247 0.29817814104719836 1.589044817445627 0.1674305187064414 0.4060699972674333 1.7739482571372466e-07 6.751059051904234 -1.1073187034714393 RPSSVK(ub)VFSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPSSVKVFSGK 11 2 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 28361600.0 13611000.0 8452500.0 6298100.0 True False 20648882.097387977 6944085.335316078 5053277.774444706 1.0 0.33629352439348204 0.24472403642054455 24.299560342407784 -13.999999999999998 0.27907868094994986 6.381786018289689 0.21690643076319352 0.9996031406074218 0.0067043235671270995 15.348701290938706 0.16733519355102872 47.120368304110535 0.036381734917327 1.0000000000000041e-14 13.999999999999998 -6.164879587526495 RPSSVK(ub)VFSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPSSVKVFSGK 11 2 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 13169500.0 6274600.0 4168100.0 2726800.0 True False 8594489.184689226 3983939.559936502 2082786.0002088135 1.0 0.4635458227155312 0.2423397080909965 23.034980464685958 -11.352065265700192 0.16388116148894796 2.141353322914553 7.388609089735013e-13 0.9995572411615488 0.006693684126717376 3.8680031897902403 0.09951976391634718 1.7817017267213366 0.1828763118098168 4.445644533790868e-12 11.352065265700192 -2.141353322913814 RPSSVK(ub)VFSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPSSVKVFSGK 11 2 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 17338800.0 5945900.0 9084100.0 2308800.0 True False 4944279.298032076 9035162.150247334 2791559.405314935 1.0 1.8273972010123927 0.5646039062611273 22.237328811454947 -6.729937280341007 1.7233720925927771 1.4979653331063336 0.565358596435171 0.5589695841851081 0.3478213337226095 0.3363786723801733 1.9571849175430995 0.1599374823621061 0.396915319521049 1.862356073775156e-07 6.729937280341007 -0.9326067366711627 RPSSVK(ub)VFSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPSSVKVFSGK 11 2 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 29013500.0 13611000.0 7733600.0 7668900.0 True False 17619707.812921103 7303218.3616192425 6273238.88955895 1.0 0.414491456905066 0.3560353529221739 24.070686664500233 -13.999999999999998 0.3257144415391963 7.211656715409978 0.34515606275557825 0.9997058781606512 0.00498670671846983 18.467806346389324 0.1822789516180645 78.40962066286563 0.019037660117370903 1.0000000000000041e-14 13.999999999999998 -6.8665006526544 RPTPNDDTLDEGVGLVHSNIATEHIPSPAKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPTPNDDTLDEGVGLVHSNIATEHIPSPAKK 31 2 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 69597000.0 27640000.0 22661000.0 19296000.0 True False 41931900.75466935 18616967.49879889 15482137.14226275 1.0 0.44398100643519683 0.36922097170943835 25.321544892611506 -13.999999999999998 0.2827719077118105 5.601458128526289 0.347323100999246 0.9996113272888124 0.005547561019686186 15.550154622265598 0.16849468044339336 41.44771661050654 0.02918905180345809 1.0000000000000041e-14 13.999999999999998 -5.2541350275270435 RPTPNDDTLDEGVGLVHSNIATEHIPSPAKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPTPNDDTLDEGVGLVHSNIATEHIPSPAKK 31 2 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 29819100.0 6938100.0 15758000.0 7123000.0 True False 9503303.06510254 15061759.455262447 5440694.1027898565 1.0 1.5848973090810223 0.5725055873224593 23.179997607757898 -6.7500637768256615 1.6497353613410524 1.3438997297360376 0.5704981413693935 0.6492053012583989 0.24577751576060178 0.2999280512446901 1.6060974385310214 0.11769023595925279 0.28568674613085376 1.7780182860928332e-07 6.7500637768256615 -0.7734015883666441 RPTPNDDTLDEGVGLVHSNIATEHIPSPAKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPTPNDDTLDEGVGLVHSNIATEHIPSPAKK 31 2 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 41796800.0 16367000.0 21695000.0 3734800.0 True False 13609885.681039201 21578124.728879657 4515729.412235898 1.0 1.585474355522436 0.33179774746580337 23.698151612898375 -6.779688796749449 1.5368917874091128 1.3316345591433436 0.32192692660651995 0.7663788535455647 0.24756025964154904 0.25104239114534266 1.171183355031693 0.12686739035034453 0.2994556667797265 1.6607765470702253e-07 6.779688796749449 -1.0097076325368237 down RPTPNDDTLDEGVGLVHSNIATEHIPSPAKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPTPNDDTLDEGVGLVHSNIATEHIPSPAKK 31 2 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 79492000.0 27640000.0 28945000.0 22907000.0 True False 35780524.865854084 27334185.30530009 18738161.045668464 1.0 0.763940311322418 0.5236972100303253 25.092671214703955 -6.970906213213424 0.23553825788705293 1.0911815636313702 0.1895452934077625 0.9999886127527102 0.0006561538006106409 0.07600974982894655 0.007970352220446984 0.005928707545501599 0.02361172191015551 1.069285768752177e-07 6.970906213213424 -0.9016362702236077 RPVGASFSFGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPVGASFSFGGK 12 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3;O94979-5 D6REX3 SEC31A Protein transport protein Sec31A 0 122082000.0 39522000.0 41152000.0 41408000.0 False True 51813724.73159246 35012282.00923962 37123497.37358332 1.0 0.6757337402514807 0.7164799976433261 25.626830962500257 -10.54861179624918 9.601336631537375 1.0000140861006714 0.6961068690501676 0.9866961170308522 0.01663458992302145 5.01598362391654e-06 2.358175918792512e-07 0.016107117307573613 0.005368790811904318 2.8274061853943955e-11 10.54861179624918 -0.30390721705050383 RPVGASFSFGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RPVGASFSFGGK 12 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3;O94979-5 D6REX3 SEC31A Protein transport protein Sec31A 0 61699800.0 19706000.0 7650800.0 34343000.0 False True 19080443.816519056 10705804.338394938 25347538.032084238 1.0 0.5610878049454121 1.3284564172526947 24.185591393439886 -6.751594936211968 1.6440773592528324 0.7424045899702028 1.330154729184876 0.6557201537315794 0.18445003521118059 0.29728731816882287 1.581512922821211 0.08861003700214104 0.21475078900986522 1.7717606982031005e-07 6.751594936211968 0.5877501392146733 RPVGASFSFGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPVGASFSFGGK 12 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3;O94979-5 D6REX3 SEC31A Protein transport protein Sec31A 0 54116000.0 14530000.0 13756000.0 25830000.0 False True 22043072.28528747 11301134.32388144 20724689.17830883 1.0 0.5126841747656166 0.9401905918596207 24.39382197985609 -10.252094430356964 8.08032362138889 1.0000002475926273 0.7264373833126189 0.35315595962961777 0.1745287639409584 7.783648161218669e-07 7.198744849401445e-08 0.16898690264489305 0.05632891634812477 5.5963590442971365e-11 10.252094430356964 -0.2735628642800084 RPVGASFSFGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPVGASFSFGGK 12 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3;O94979-5 D6REX3 SEC31A Protein transport protein Sec31A 0 85532000.0 39522000.0 21380000.0 24630000.0 False True 54134351.4418908 20435360.905794594 18812901.27077273 1.0 0.377493409664849 0.34752242835987385 25.69004102402315 -13.613219819341897 0.4360222054442449 9.999999999864674 0.34710348321447043 0.9998777853436095 0.0033249812575009336 23.035492542527717 0.22216396909938038 196.23855113394058 0.006992608579302439 2.4365772259633387e-14 13.613219819341897 -9.652896516650204 RPVGASFSFGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPVGASFSFGGK 12 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3;O94979-5 D6REX3 SEC31A Protein transport protein Sec31A 0 42507000.0 19706000.0 11559000.0 11242000.0 False True 16386412.123819815 11496729.372718142 13592650.22286493 1.0 0.7016013808175938 0.8295074065119 23.965996668874162 -10.081583893366906 4.754501123734642 1.0000100793300248 0.765554393661215 0.8175055051819409 0.052217416341863894 5.579189934485667e-06 1.0777704901682095e-06 0.05056146893802192 0.016853098654446216 8.287358125736748e-11 10.081583893366906 -0.2344556856688098 RPVGASFSFGGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPVGASFSFGGK 12 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3;O94979-5 D6REX3 SEC31A Protein transport protein Sec31A 0 87862000.0 14530000.0 45385000.0 27947000.0 False True 18809371.42911939 42859284.85337869 22860932.760435525 1.0 2.2786133505251995 1.215401208200067 24.164948301948538 -6.600790818150712 2.188000899459533 1.8594707194685607 1.2188978173662872 0.02271663396334689 0.5525494613989053 0.638484913686082 5.778066463885218 0.20955166248063262 0.6144445282421382 2.507316633878197e-07 6.600790818150712 -0.6405729021022735 RPVHGESDTEQLQDDDIETTK(ub)VEMLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPVHGESDTEQLQDDDIETTKVEMLR 26 2 J3KT10;Q9BW27;Q9BW27-3;J3QL54;F5H0W7;J3KS87 J3KT10 NUP85 Nuclear pore complex protein Nup85 1 39291300.0 4671900.0 6600300.0 28019100.0 True False 6047866.64691692 6232987.502870006 22919911.30024401 1.0 1.0306092820428598 3.7897514344050753 22.527994898375113 -6.909322905984954 0.9003192691783601 0.9127310363295096 4.141224690101061 0.9906638597408806 0.12637863175580813 0.10486786968607646 0.14120322722998152 0.10312269528971166 0.2833525126047806 1.2321883377217537e-07 6.909322905984954 3.2284936537715514 up RPVLLLHPLGGWTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPVLLLHPLGGWTK 14 1 O43252 O43252 PAPSS1 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 0 10600400.0 2892900.0 3454500.0 4253000.0 False True 3962483.307682952 3301868.7674961397 3248528.993284469 1.0 0.8332826944896068 0.8198214960264488 21.917973427106503 -13.999999999994216 0.35665848790741417 3.1365006390968424 0.8181223895530274 0.9997671828119796 0.0012503869397927027 21.34158992769474 0.1927500523758987 34.65294997135557 0.003927489652353189 1.0000000000133177e-14 13.999999999994216 -2.318378249543815 RPVLLLHPLGGWTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPVLLLHPLGGWTK 14 1 O43252 O43252 PAPSS1 Bifunctional 3-phosphoadenosine 5-phosphosulfate synthase 1;Sulfate adenylyltransferase;Adenylyl-sulfate kinase 0 5260560.0 2132100.0 978160.0 2150300.0 False True 1772935.6180450728 972890.4579304426 2599917.788136139 1.0 0.5487455088770794 1.4664479418620615 20.75770871683345 -6.772981606684993 1.5628370279401065 0.7421580850350183 1.4722270181578312 0.7418967298282952 0.19034560360974906 0.26163909873662455 1.2615316795445473 0.09597421881062654 0.22785842394316302 1.6866244560867682e-07 6.772981606684993 0.7300689331228128 RPVVGSSEPFCHSK(ub)YSTPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPVVGSSEPFCHSKYSTPR 19 2 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 34484200.0 3900600.0 12796600.0 17787000.0 True False 5917495.372057271 10512946.749707848 14271391.653680962 1.0 1.776587236443064 2.41172840135562 22.496555241984506 -6.973420971957531 0.1561515832798434 0.3222103568580329 3.882899777875009 0.9999982619579837 0.0007610594478203963 0.0752074616814505 0.004801647833023165 0.03050883232572823 0.07732840456827261 1.0631120188859199e-07 6.973420971957531 3.560689421016976 RPVVGSSEPFCHSK(ub)YSTPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPVVGSSEPFCHSKYSTPR 19 2 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 5490890.0 766260.0 2277530.0 2447100.0 True False 1049567.029397885 2176901.193815451 1869145.3796064926 1.0 2.0740944911963313 1.7808728049306033 20.001362874965146 -10.074781414352938 4.440631790829662 0.9999301724361385 1.9274836481250794 0.9302654789843652 0.11970725238468505 36941571.331809 49234038.974651106 33819.029798486205 0.04380836838103174 8.418187325511357e-11 10.074781414352938 0.927553475688941 RPVVGSSEPFCHSK(ub)YSTPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPVVGSSEPFCHSKYSTPR 19 2 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 8179840.0 2621740.0 2433100.0 3125000.0 True False 2180092.972774959 2419992.407367463 3778423.0516325245 1.0 1.1100409191664633 1.7331476679286344 21.055958231161803 -6.937072586483378 0.6862593728602011 0.9925265441287086 1.887631837915572 0.9977547573539957 0.01529618716581194 0.08912786999158756 0.060884310232107816 0.014578067422773242 0.054357233690261644 1.1559190297221152e-07 6.937072586483378 0.8951052937868635 RPVVGSSEPFCHSK(ub)YSTPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPVVGSSEPFCHSKYSTPR 19 2 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 39888600.0 3900600.0 14896400.0 21091600.0 True False 5049403.59232092 14067402.245011985 17253145.218091484 1.0 2.7859532294874474 3.4168679335377123 22.267681564076955 -9.583078186434221 0.2974329424940006 1.6499453327796744e-15 3.6659676920576763 0.9987601693821592 0.03604053183660928 0.9609207002458429 0.12213555381077705 1.146559092728029 0.22411054674648762 2.6116911269218504e-10 9.583078186434221 3.6659676920576745 RPWILTSLHNGVIQLWDYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPWILTSLHNGVIQLWDYR 19 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ITV3;A0A3B3ISK1;A0A3B3ITX2;A0A3B3IS23;A0A3B3IU84 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 24148100.0 5132500.0 11883000.0 7132600.0 False True 7786377.736010871 9762385.80769723 5722838.483670364 1.0 1.253777576516434 0.7349808444564748 22.89252090433185 -6.773686393426902 1.560175285831439 1.144876991625791 0.7316371734366237 0.7444780978600811 0.10707045661693726 0.2605322798997749 1.252010357667329 0.05407538206620315 0.1283004032225209 1.6838895686133183e-07 6.773686393426902 -0.41323981818916733 RPWILTSLHNGVIQLWDYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPWILTSLHNGVIQLWDYR 19 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ITV3;A0A3B3ISK1;A0A3B3ITX2;A0A3B3IS23;A0A3B3IU84 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 16320800.0 5132500.0 4044900.0 7143400.0 False True 6644122.426700294 3819797.759247138 5843374.497473615 1.0 0.5749138131315538 0.8794802567139994 22.6636472264243 -9.943584818440321 6.286741791505315 1.000000062293053 0.727197034922758 0.5168444038366151 0.12433872992525934 1.0842860296308965e-07 1.8262773042917436e-08 0.12039048448151664 0.04013015252408268 1.138715367137404e-10 9.943584818440321 -0.27280302737029494 RPYEPINSIK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPYEPINSIKR 11 2 Q8WUA4;H7C3X9;H0Y4Q6 Q8WUA4 GTF3C2 General transcription factor 3C polypeptide 2 1 1598730.0 460520.0 393350.0 744860.0 True False 603746.1796820237 334663.7132662911 667789.0324016438 1.0 0.5543119352615186 1.1060757895865274 19.203582629488764 -6.691801142360068 1.860245066422072 0.7210461410998847 1.1041974633860454 0.3787201516642198 0.18842767520572684 0.412833884904978 2.771275865236515 0.08099422518069435 0.21041920068742032 2.0332878131385086e-07 6.691801142360068 0.38315132228616067 RPYEPINSIK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPYEPINSIKR 11 2 Q8WUA4;H7C3X9;H0Y4Q6 Q8WUA4 GTF3C2 General transcription factor 3C polypeptide 2 1 2127720.0 460520.0 598700.0 1068500.0 True False 630786.6890850547 572247.4543638552 816142.3064482609 1.0 0.9071964647730445 1.2938483334707989 19.266792691011656 -6.843358552499491 1.2668731351417253 0.9506339484905026 1.3074210279603895 0.9300474060722045 0.043589679405124655 0.16491641705183377 0.5127220593976014 0.02696496022674469 0.06218353535169749 1.434304785753105e-07 6.843358552499491 0.35678707946988686 RPYEPINSIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RPYEPINSIKR 11 2 Q8WUA4;H7C3X9;H0Y4Q6 Q8WUA4 GTF3C2 General transcription factor 3C polypeptide 2 1 3859110.0 814810.0 1499700.0 1544600.0 True False 677550.6172033711 1491620.8184328552 1867568.718576511 1.0 2.2014898674133088 2.7563530622774834 19.369969203132847 -9.482859902044849 0.22296515215030244 1.4869274614161343e-19 3.192544947007692 0.9993084639562516 0.019277001516890723 0.9011186433924354 0.08859464154335407 0.9002706342120645 0.2795662481041252 3.2895773140174987e-10 9.482859902044849 3.192544947007692 RPYEPINSIK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPYEPINSIKR 11 2 Q8WUA4;H7C3X9;H0Y4Q6 Q8WUA4 GTF3C2 General transcription factor 3C polypeptide 2 1 6625100.0 1989300.0 2247400.0 2388400.0 True False 2575188.064965395 2122330.2143766247 1953735.7070535047 1.0 0.8241457170644134 0.7586769034982145 21.296246364915365 -13.999999999999998 0.1372102851634528 1.8381887261535543 0.6748666618842907 0.999614283831606 0.002001221875944476 11.932234061577386 0.11584401545479062 2.6823481516650958 0.0747939286860985 1.0000000000000041e-14 13.999999999999998 -1.1633220642692637 RPYGVGLLIAGYDDMGPHIFQTCPSANYFDCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RPYGVGLLIAGYDDMGPHIFQTCPSANYFDCR 32 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 0 269805600.0 56916600.0 89299000.0 123590000.0 False True 86346643.36082527 73362895.7537284 99162382.32857859 1.0 0.849632283297448 1.1484219706630507 26.363636759732778 -6.76988338369291 1.574848802735314 0.9137387773972558 1.1500965314341396 0.7301062216890295 0.06337084285800869 0.2666326579192457 1.3050492089647967 0.031717542038058495 0.07551057671328125 1.698699724327863e-07 6.76988338369291 0.23635775403688375 RPYGVGLLIAGYDDMGPHIFQTCPSANYFDCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RPYGVGLLIAGYDDMGPHIFQTCPSANYFDCR 32 1 P25786;P25786-2;F5GX11 P25786 PSMA1 Proteasome subunit alpha type-1 0 147357600.0 56916600.0 33556000.0 56885000.0 False True 73679660.69391708 31688579.101905372 46532513.689389765 1.0 0.43008584463421057 0.6315516826644595 26.134763081825227 -10.07632682319261 5.058806583836498 1.0000099008646046 0.5308187636482462 0.8785127028863358 0.08224808396873341 9.247873128027125e-06 1.688549346596771e-06 0.07963805597358475 0.026545454954835613 8.388284984418977e-11 10.07632682319261 -0.4691911372163584 RPYWCISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RPYWCISR 8 1 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 18348200.0 4748000.0 5858800.0 7741400.0 False True 6224673.97969741 4984689.877423529 6940394.188752358 1.0 0.8007953338089269 1.1149811558628393 22.569566846634867 -6.735361971641537 1.7036541021746423 0.8808456226577225 1.114987524105016 0.5840284864145862 0.08371107292612429 0.3262363280747309 1.857308026686454 0.038901377611317775 0.09595166814353825 1.8392384114874508e-07 6.735361971641537 0.23414190144729352 RPYWCISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RPYWCISR 8 1 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 15831400.0 4748000.0 4885100.0 6198300.0 False True 6503463.909875451 4669260.129134578 4734389.197995562 1.0 0.717965101958104 0.7279796218760337 22.63277690815776 -9.99046897271256 5.265252876940681 1.0000013399449068 0.7229723619159988 0.9990208465651034 0.004088410640053282 6.430523600313213e-08 1.2334812096277585e-08 0.003958605689677894 0.0013195288595757456 1.0221885861794826e-10 9.99046897271256 -0.277028978028908 RQETK(ub)EAQLYAAQAHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RQETKEAQLYAAQAHLK 17 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 1 26170400.0 9291600.0 10437000.0 6441800.0 True False 12181377.579982411 8879840.283107348 5775264.330108893 1.0 0.7289684787129117 0.47410601076838405 23.53817395964188 -6.971868358280735 0.20879427376021475 1.1355050699428595 0.06046424868681643 0.9999935199082677 0.0005465845417287787 0.07570099410465961 0.006816373139422086 0.0077055312334542115 0.02648410215194659 1.0669194728619717e-07 6.971868358280735 -1.0750408212560432 down RQETK(ub)EAQLYAAQAHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RQETKEAQLYAAQAHLK 17 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 1 35052600.0 9640600.0 12497000.0 12915000.0 True False 9334564.429997649 17487117.270994067 9532174.058304993 1.0 1.873372603738991 1.0211696678285602 23.154151274224155 -10.278257481233005 4.597820386880391 0.9997976348832552 1.4472711356483696 0.2686196216375224 0.34791039179439526 0.0007665550475335293 0.00012033018114038628 0.33702281684815155 0.11228759610392335 5.269173740055207e-11 10.278257481233005 0.4474735007651144 RQETK(ub)EAQLYAAQAHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RQETKEAQLYAAQAHLK 17 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 1 110403000.0 39377000.0 29364000.0 41662000.0 True False 59737787.84430579 24123764.778020818 33427487.4388967 1.0 0.40382755452703456 0.559570225901544 25.832140478272347 -10.466417701928295 9.288384974604092 1.0000057340878041 0.4816988902145806 0.9365757777383398 0.06358167934091871 7.549950039009094e-06 4.336811866161117e-07 0.061563376973171456 0.020520898767606523 3.416506867809824e-11 10.466417701928295 -0.5183068438732235 RQETK(ub)EAQLYAAQAHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RQETKEAQLYAAQAHLK 17 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 1 27866600.0 9291600.0 9383400.0 9191600.0 True False 12726955.616048604 8968810.361245684 7020733.386944165 1.0 0.7047098011354794 0.5516427964980932 23.601384021164773 -13.999999999787176 0.08343936045744267 2.5611555652311213 0.122272649947199 0.9998720953385007 0.002104523875761832 12.224868689924072 0.0822571805540138 3.4700905140309533 0.38835411374597406 1.0000000004900443e-14 13.999999999787176 -2.4388829152839224 RQETK(ub)EAQLYAAQAHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RQETKEAQLYAAQAHLK 17 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 1 34980000.0 9640600.0 19243000.0 6096400.0 True False 8016586.050994488 19139334.13956354 7371129.053431215 1.0 2.387466936401092 0.9194848039480344 22.93455654965843 -6.658870211879419 1.9765264468020614 1.8938947726103328 0.9255651631706956 0.2310020425123861 0.5909055726765888 0.4871025215767058 3.6568122263715326 0.24161562683699814 0.6551235235615288 2.1934603490698472e-07 6.658870211879419 -0.9683296094396372 RQETK(ub)EAQLYAAQAHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RQETKEAQLYAAQAHLK 17 2 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;E9PRH9;E9PI86 P49321 NASP Nuclear autoantigenic sperm protein 1 105953000.0 39377000.0 45466000.0 21110000.0 True False 50974302.736712515 42935777.13217396 17268196.606891416 1.0 0.8423023921276891 0.3387627820253553 25.603266800364796 -6.950041046674703 0.5583974178708994 1.0066416920002113 0.15042482235075724 0.9992044683377961 0.007953518975131989 0.08346936016830195 0.0358948625561381 0.008542314005312971 0.04184332215317353 1.1219124134654406e-07 6.950041046674703 -0.856216869649454 down RQPVLDFESGHK(ub)SNVFQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RQPVLDFESGHKSNVFQAK 19 2 Q5TAQ9;V9GY54 Q5TAQ9 DCAF8 DDB1- and CUL4-associated factor 8 1 6735300.0 1683500.0 1391000.0 3660800.0 True False 1630058.2140013112 1946433.553969172 2701926.658354077 1.0 1.1940883689001835 1.6575645183380572 20.63649205743164 -6.956436549278635 0.4830428504752434 0.9891876662838224 1.8818884626570396 0.9996143573957448 0.00541720860084877 0.08099948542258743 0.026027931808090852 0.006575750917264425 0.038229389995301295 1.1055119736414101e-07 6.956436549278635 0.8927007963732172 RQPVLDFESGHK(ub)SNVFQAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RQPVLDFESGHKSNVFQAK 19 2 Q5TAQ9;V9GY54 Q5TAQ9 DCAF8 DDB1- and CUL4-associated factor 8 1 19951300.0 3647600.0 4774700.0 11529000.0 True False 5533675.875279731 3922617.4800986266 9250288.096659789 1.0 0.7088628912332773 1.6716353297783602 22.39980671258157 -6.825595212842437 1.3473788839011536 0.8438949482955702 1.6953034101302271 0.8967800687510699 0.12952418430127596 0.18632062401281232 0.6630445008772484 0.07550728192934288 0.17383803404604806 1.4941864274903255e-07 6.825595212842437 0.8514084618346569 RQPVLDFESGHK(ub)SNVFQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RQPVLDFESGHKSNVFQAK 19 2 Q5TAQ9;V9GY54 Q5TAQ9 DCAF8 DDB1- and CUL4-associated factor 8 1 4762700.0 1683500.0 1739100.0 1340100.0 True False 1399904.8416954565 1729731.1231156786 1620308.7140776792 1.0 1.2356062152201446 1.1574420387854982 20.416897332865915 -10.080368869103452 4.307302668653774 0.9999797339529661 1.1965241269787623 0.8939396093228068 0.031910391500637 4678534.543518086 5474581.096422331 748.1195634816568 0.010923776308780277 8.310576103973428e-11 10.080368869103452 0.19654439302579618 RQPVLDFESGHK(ub)SNVFQAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RQPVLDFESGHKSNVFQAK 19 2 Q5TAQ9;V9GY54 Q5TAQ9 DCAF8 DDB1- and CUL4-associated factor 8 1 17083300.0 3647600.0 7253000.0 6182700.0 True False 4721890.104945341 6849364.174100596 5057512.039859198 1.0 1.4505556084261901 1.0710778792929452 22.170933034674018 -10.23895018109216 5.985306269159573 0.9999927352743858 1.2608167438595688 0.3864465802298025 0.15492113418776038 1.5018599160101615e-05 1.9095455396586314e-06 0.15000591935512286 0.05000058105706279 5.7683262938009765e-11 10.23895018109216 0.26082400858518295 RRPTLGVQLDDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RRPTLGVQLDDK 12 2 Q13769;H7C072 Q13769 THOC5 THO complex subunit 5 homolog 0 10261200.0 3019600.0 2236000.0 5005600.0 False True 3958724.841847992 1902397.5158597329 4487668.529105701 1.0 0.4805581574524551 1.1336146634052973 21.916604363113738 -6.6947960179437915 1.8494923175704676 0.675818880242366 1.1314909948230898 0.39294062531321816 0.2194778639316241 0.40642268620499883 2.6989859029545253 0.09480759847049099 0.245392763953432 2.019314584855643e-07 6.6947960179437915 0.45567211458072376 RSAVPPGADKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 RSAVPPGADKK 11 2 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 18719360.0 947760.0 13659300.0 4112300.0 True False 1242522.5381208959 11621385.68353439 3686798.6439670315 1.0 9.353058256077802 2.9671885465696968 20.24484059039974 -6.578057475240489 2.273715146275795 6.694672873467625 2.982151746037398 0.0 3.6305505999006034 0.7052834261285835 6.854819268529028 1.3421033607184731 4.062154166331739 2.64205907977364e-07 6.578057475240489 -3.712521127430227 RSAVPPGADKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 RSAVPPGADKK 11 2 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 15350300.0 7545400.0 7804900.0 0.0 True False 7305875.4071431495 10921437.272015808 0.0 1.0 1.4948841395977854 0.0 22.800625719817234 -6.838591674467944 1.4326346187603056 1.2659322995329862 2.0201665321810042e-22 0.8777668494088646 0.21738882574897156 0.18578218767592938 0.7654757800414894 0.12165413754927151 0.2607256067088917 1.4501346355932157e-07 6.838591674467944 -1.2659322995329862 down RSAVPPGADKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 RSAVPPGADKK 11 2 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 2827880.0 1456800.0 637320.0 733760.0 True False 2210072.1063459595 523585.2665961121 588732.0143815668 1.0 0.23690868053250355 0.26638588518948897 21.07566200942536 -10.611576918555105 6.472756475630757 1.0022905423400437 0.25164728286101196 0.9988377054393538 0.012034018408867718 0.0003985289826534288 2.391526435872143e-05 0.011673904024224304 0.0038839627404581812 2.4458120562014018e-11 10.611576918555105 -0.7506432594790318 RSAVPPGADKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RSAVPPGADKK 11 2 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 2402950.0 947760.0 1024300.0 430890.0 True False 1298172.484250959 979043.0390928616 329122.65645811055 1.0 0.7541702285099395 0.25352767867978127 20.30805065192263 -7.0162598624425625 0.455415283918978 1.0155462810259592 1.4362130808021576e-14 0.9997416434825753 0.004992546372715606 0.0740595764417449 0.022422633356709274 0.006666155481748854 0.0382834119496051 9.632524838410895e-08 7.0162598624425625 -1.0155462810259448 down RSDPNFK(ub)NR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RSDPNFKNR 9 2 Q15388 Q15388 TOMM20 Mitochondrial import receptor subunit TOM20 homolog 1 4179440.0 657440.0 1081100.0 2440900.0 True False 636569.9270644612 1512788.8678620197 1801555.06456962 1.0 2.3764692668380323 2.830097665589516 19.279959476996922 -9.914959699132908 0.28000906790299024 1.471317181038455e-15 3.02561072674132 0.9989395899608159 0.025339736810587724 1.3286371557829797 0.12375667788114628 1.2554900317686046 0.1754373605943619 1.2162988632928214e-10 9.914959699132908 3.0256107267413186 RSGMYTVAMAYCGSGNNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RSGMYTVAMAYCGSGNNK 18 1 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 4006400.0 1074900.0 1609700.0 1321800.0 False True 1409204.3093464056 1369539.0345614552 1185032.8156009074 1.0 0.9718527153785478 0.8409233549324939 20.426449361037488 -6.94142861689336 0.646136896596854 1.0014410664214068 0.8040808778612191 0.9983450822940937 0.00281974356249863 0.08712092398120576 0.05168689598683861 0.002775482663614938 0.011199806054931321 1.1443829616399782e-07 6.94142861689336 -0.19736018856018778 RSIQFVDWCPTGFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RSIQFVDWCPTGFK 14 1 P68363;P68363-2;P68366-2;P68366 P68363;P68366-2 TUBA1B;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 11921700.0 4612400.0 2297500.0 5011800.0 False True 6046901.066545141 1954721.9555848571 4493227.012580295 1.0 0.32326011854228587 0.7430627627495603 22.527764544547754 -10.373813194047434 5.739914988187402 1.0001188249628683 0.5331614406464125 0.622478051484463 0.17138371182983364 0.0002606717067277345 2.8437769845833094e-05 0.16598338913004973 0.055313855144012394 4.228504586131228e-11 10.373813194047434 -0.46695738431645584 RSIQFVDWCPTGFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RSIQFVDWCPTGFK 14 1 P68363;P68363-2;P68366-2;P68366 P68363;P68366-2 TUBA1B;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 23857400.0 4361900.0 11164000.0 8331500.0 False True 6617321.197604636 9171696.975269873 6684775.373173829 1.0 1.3860135697493239 1.0101935773638449 22.657815877433347 -9.441926663301977 9.460918155837945 0.9999729727367778 1.1981035735565848 0.27032810445313504 0.15342787020701876 0.0 0.0 0.14855589618042056 0.04951863206014018 3.6147089690328924e-10 9.441926663301977 0.19813060081980705 RSIQFVDWCPTGFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RSIQFVDWCPTGFK 14 1 P68363;P68363-2;P68366-2;P68366 P68363;P68366-2 TUBA1B;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 12259600.0 4612400.0 4465800.0 3181400.0 False True 6317728.925423236 4268486.189574254 2430018.8429897055 1.0 0.6756361724222444 0.38463486985189294 22.590974606070645 -7.295905269472406 0.22555328667187374 1.1458346461676354 1.584242779687608e-11 0.9999640874389235 0.001506225202109978 0.1057028856192939 0.01411564929004337 0.017073388598377714 0.04680367407719925 5.059350070925245e-08 7.295905269472406 -1.145834646151793 down RSIQFVDWCPTGFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RSIQFVDWCPTGFK 14 1 P68363;P68363-2;P68366-2;P68366 P68363;P68366-2 TUBA1B;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 23651000.0 4361900.0 6722100.0 12567000.0 False True 5646565.53590336 6348009.22579919 10279934.948309071 1.0 1.124224838166801 1.8205641788702709 22.428942199525796 -6.937291467407599 0.6843008055762273 0.9916975214532967 1.9942687339737308 0.9977871421586489 0.01698728656564487 0.08902431519071347 0.060402032388930896 0.01621434564430507 0.06068226171612248 1.1553366026141409e-07 6.937291467407599 1.0025712125204342 RSPGTGAGLAEK(ub)SDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RSPGTGAGLAEKSDR 15 2 P08034 P08034 GJB1 Gap junction beta-1 protein 1 1999380.0 753510.0 671060.0 574810.0 True False 729590.2375005209 939017.7575316706 424250.01706963097 1.0 1.2870481391700368 0.5814908084886868 19.476726899657923 -6.796240170592469 1.4711163069146802 1.1591385826587117 0.5726202411778816 0.8209783836153055 0.12257667012706526 0.226163283206331 0.9666395024162628 0.06556063660729 0.15283889132563971 1.5986736964153373e-07 6.796240170592469 -0.5865183414808302 RSPSKPLPEVTDEYK(ub)NDVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RSPSKPLPEVTDEYKNDVK 19 3 P05455;E7ERC4;E9PFL9;E9PGX9 P05455 SSB Lupus La protein 1 14086800.0 3215800.0 2590900.0 8280100.0 True False 4162916.4928948414 2446714.137415856 6773206.761000548 1.0 0.5877403838371115 1.627034021114976 21.989163187976498 -6.799062747907608 1.4596373704265608 0.7722695371406254 1.6410694925901301 0.8294490018668808 0.1764652278372283 0.22208948622682373 0.9342351040338346 0.09511170726895199 0.22133200359162847 1.588317248136099e-07 6.799062747907608 0.8687999554495047 RSYVTMTATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RSYVTMTATK 10 1 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 4581890.0 614090.0 2375400.0 1592400.0 False True 794951.6105236013 2243206.901855582 1302599.5394037846 1.0 2.8218156579091342 1.638589723147824 19.60050751925855 -10.252715401014852 4.972677737443288 0.999763423740363 2.2302026905293895 0.5903834733227994 0.483049965101966 170664324.5001443 188.07833484810928 462296.11799891427 0.165360851429775 5.5883628766785176e-11 10.252715401014852 1.2304392667890265 RTDEAAFQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RTDEAAFQK 9 1 P26447 P26447 S100A4 Protein S100-A4 0 11626800.0 4013200.0 1943500.0 5670100.0 False True 3885803.1627146197 2719549.6852186066 4184930.710646161 1.0 0.6998681022532112 1.0769795935115176 21.8897813916659 -6.694657729437797 1.849693494891841 0.812666753265505 1.0757610063741567 0.3923946446851071 0.12681683533756313 0.40672970325495966 2.7014385575406323 0.05477338514232598 0.14181100465779087 2.0199576795129575e-07 6.694657729437797 0.26309425310865175 RTELSIDISSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RTELSIDISSK 11 1 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;K7EPY1;K7ENL0;K7EJV0 Q9UHD8 SEPT9 Septin-9 0 26758800.0 4967800.0 10161000.0 11630000.0 False True 7536515.794828015 8347690.161744643 9331325.402389912 1.0 1.1076325438703787 1.2381484569824157 22.84546627487676 -6.96855049282862 0.2907304945506458 0.9747198613065295 1.3750976581409404 0.99996876197674 0.0005441977762090291 0.07677589402505657 0.010705018662766793 0.002271268622577321 0.011825798183272547 1.0751015974769925e-07 6.96855049282862 0.4003777968344109 RTTVVAQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RTTVVAQLK 9 1 P60228;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 11660300.0 4485900.0 3062600.0 4111800.0 False True 5881058.341517398 2605672.017921297 3686350.379170689 1.0 0.44306175293765165 0.6268175156751731 22.487644371777826 -10.156770299309313 5.5282586813364745 1.0000101371860102 0.5349396343063497 0.8951819964970752 0.07501797600070292 9.373032189743912e-06 1.4296953142486745e-06 0.0726374252022443 0.02421194764304298 6.96995061080917e-11 10.156770299309313 -0.46507050287966045 RTTVVAQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RTTVVAQLK 9 1 P60228;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 8171300.0 2015000.0 1216600.0 4939700.0 False True 1951034.9279552375 1702394.7244851873 3645844.3821764733 1.0 0.8725598399559996 1.8686720211603098 20.895808175019322 -6.8747738885384395 1.1085835835844942 0.9253668541797756 1.9325425650092742 0.9692173630124554 0.07765449925164264 0.13235746450273023 0.3011487905107146 0.05419163711016539 0.1294711530919118 1.3342158987044055e-07 6.8747738885384395 1.0071757108294985 RTTVVAQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RTTVVAQLK 9 1 P60228;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 14085000.0 3242500.0 5724200.0 5118300.0 False True 4919109.558502726 4702671.786621263 4106665.761569414 1.0 0.9560006197651466 0.8348392555052986 22.229965756474947 -6.953358974419679 0.5206631623526448 1.0020483477739024 0.7833783771912124 0.9994391984950627 0.0016538028122812592 0.08216431659043777 0.030592301515609002 0.0018715754330678991 0.010008652781943952 1.113373872656394e-07 6.953358974419679 -0.21866997058269 RTTVVAQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RTTVVAQLK 9 1 P60228;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 9182700.0 4485900.0 2303500.0 2393300.0 False True 6144458.4568892745 2201723.753344144 1828051.831560712 1.0 0.3583267376273873 0.2975122778332187 22.550854433300717 -13.999999999999932 0.33327736786910234 8.12462559034463 0.2871509660255922 0.9997216037915304 0.005302440899042005 19.103832163518927 0.18478655900472338 95.56533770871079 0.01925281112485517 1.0000000000001554e-14 13.999999999999932 -7.837474624319038 RTTVVAQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RTTVVAQLK 9 1 P60228;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 6341000.0 2015000.0 2601100.0 1724900.0 False True 1675561.7796354885 2587087.3580220756 2085568.614963505 1.0 1.544011918548826 1.2446981306873757 20.6762134504536 -10.090201066350316 4.490164955802002 0.999971741532612 1.3943550246345378 0.6982967566874942 0.12219434229655332 64235288.47539642 0.7359687502044795 21527.179592676977 0.04471855032083854 8.124542851837266e-11 10.090201066350316 0.3943832831019257 RTTVVAQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RTTVVAQLK 9 1 P60228;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 16404800.0 3242500.0 7979200.0 5183100.0 False True 4197480.169230531 7535150.505719485 4239828.98309706 1.0 1.795160477696981 1.010089103976468 22.001092078567396 -10.211700931078248 4.533059963013089 0.9998924847420968 1.402624790841176 0.259636823481463 0.32050404622901013 0.0003483658858698808 6.05799837489592e-05 0.3104091765931305 0.10344223611757497 6.141848066621333e-11 10.211700931078248 0.4027323060990792 RVAIFIEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RVAIFIEK 8 1 Q9P258 Q9P258 RCC2 Protein RCC2 0 26153800.0 11132000.0 6394500.0 8627300.0 False True 14594159.802441342 5440465.525565781 7734629.754905228 1.0 0.37278374358047583 0.5299811609306458 23.798887820324566 -10.399645757786772 8.999528504600159 1.000002169524601 0.4513824522563266 0.9419955211910528 0.06417557689854131 2.793559909328295e-06 1.8632779893037004e-07 0.06213798038463352 0.020712578380108662 3.9843202823050424e-11 10.399645757786772 -0.5486197172682745 RVAIFIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RVAIFIEK 8 1 Q9P258 Q9P258 RCC2 Protein RCC2 0 20817500.0 8502400.0 4618400.0 7696700.0 False True 8232495.965978452 6462551.204637831 5680703.373949357 1.0 0.7850050861057107 0.6900341521484356 22.972898469207134 -13.999999999999986 0.11082750442259069 2.035911791897062 0.5178707845023205 0.9997388600279054 0.0020953836202611377 12.00782047585828 0.10115534455000831 2.779168466424817 0.1528865235940755 1.0000000000000327e-14 13.999999999999986 -1.5180410073947417 RVAIFIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RVAIFIEK 8 1 Q9P258 Q9P258 RCC2 Protein RCC2 0 106776000.0 19280000.0 42753000.0 44743000.0 False True 29249169.556802593 35123393.11928636 35899526.4384464 1.0 1.2008338579006792 1.2273690837180404 24.801892328453206 -13.120721096523035 0.29727197049183174 6.760795300579661e-20 1.234276425633624 0.9995934131449526 0.002046801170048514 9.842974005292183 0.1703123436272974 5.9485360322598115 0.009707228356430501 7.573190884403301e-14 13.120721096523035 1.234276425633624 RVAIFIEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RVAIFIEK 8 1 Q9P258 Q9P258 RCC2 Protein RCC2 0 30666500.0 11132000.0 12315000.0 7219500.0 False True 15247801.230988508 11770882.579740895 5514402.790269745 1.0 0.7719724569742304 0.36165232657038304 23.862097881847458 -6.962058001334741 0.40539317123543955 1.0212569531399438 0.09725418671086376 0.9998390649794715 0.003350659260563935 0.07897406052163322 0.018474469079568685 0.0052791352840004325 0.03431151339908067 1.0912945810412075e-07 6.962058001334741 -0.9240027664290801 down RVAIFIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RVAIFIEK 8 1 Q9P258 Q9P258 RCC2 Protein RCC2 0 15101300.0 8502400.0 4211400.0 2387500.0 False True 7070122.320184989 4188712.35230255 2886715.2114472543 1.0 0.5924526001967322 0.40829777487806235 22.75330374464141 -13.999999999999998 0.10716104450798163 2.9771185317851776 0.056234471475470914 0.9997574949231077 0.0038500569825797165 12.030087005738332 0.09885954632112753 5.1746374253764 0.31296743800209387 1.0000000000000041e-14 13.999999999999998 -2.9208840603097066 RVAIFIEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RVAIFIEK 8 1 Q9P258 Q9P258 RCC2 Protein RCC2 0 106639000.0 19280000.0 49933000.0 37426000.0 False True 24958340.065617424 47154184.65536538 30614852.023188904 1.0 1.8893157369998705 1.2266381475170252 24.573018650545656 -10.160870481692012 4.68405383568842 0.999934525104876 1.557976942263458 0.4859387555235438 0.2705369930523023 0.00018500759675747533 3.3142965930965396e-05 0.2619769207288592 0.08731543904961356 6.904456826323957e-11 10.160870481692012 0.5580424171585819 RVATWFNQPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RVATWFNQPAR 11 1 P26373;J3QSB4;P26373-2;H3BTH3 P26373 RPL13 60S ribosomal protein L13 0 8825600.0 1938200.0 2147300.0 4740100.0 False True 2509038.107633801 2027800.8673715957 3877450.4375332114 1.0 0.8081985128890505 1.545393202971285 21.25870295209868 -6.83759565266912 1.2934054234472234 0.8979093535587502 1.5685246418381644 0.9202574541313461 0.088185308835921 0.1716265098124975 0.5587399768800133 0.053481169715024326 0.12314969896628288 1.453464227166707e-07 6.83759565266912 0.6706152882794142 RVEYFVDK(ub)QLQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RVEYFVDKQLQVK 13 2 A6NED2;G3V2I3 A6NED2 RCCD1 RCC1 domain-containing protein 1 1 16734400.0 2742400.0 5784800.0 8207200.0 True False 2655344.0131138666 8094700.80733347 6057488.1092776405 1.0 3.048456534202882 2.2812441926024305 21.34046735082913 -10.332173913765901 5.746665051845877 0.9997581186554069 2.664850363402664 0.8626096237361034 0.3132131268811887 0.00097077521732303 0.0001128143215533363 0.3033082153184515 0.10108910201869552 4.653996863182215e-11 10.332173913765901 1.6650922447472571 RVEYFVDK(ub)QLQVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 RVEYFVDKQLQVK 13 2 A6NED2;G3V2I3 A6NED2 RCCD1 RCC1 domain-containing protein 1 1 47336300.0 3003800.0 6652500.0 37680000.0 True False 4556984.207195215 5465309.398780258 30232531.484269317 1.0 1.1993259467853434 6.6343287818583825 22.119647940051966 -6.9146606961384665 0.8633794389540614 0.855497065670873 7.411541310096702 0.9925650043015326 0.22507985986940732 0.1014164170173996 0.12264176230209542 0.18863243904913055 0.5391754377482071 1.2171365488686156e-07 6.9146606961384665 6.556044244425829 up RVEYFVDK(ub)QLQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RVEYFVDKQLQVK 13 2 A6NED2;G3V2I3 A6NED2 RCCD1 RCC1 domain-containing protein 1 1 11763500.0 2742400.0 3709600.0 5311500.0 True False 2280427.1089192866 3689615.6485020514 6422110.092398783 1.0 1.6179493894240675 2.816187400719979 21.120872626263406 -6.960645538997194 0.4262380318384308 0.9504608358912047 3.529342325419867 0.9997933977066468 0.010837243716192779 0.07947131225941512 0.020285166495246483 0.015571905683998107 0.09958084530304252 1.0948495923482939e-07 6.960645538997194 2.578881489528662 RVEYFVDK(ub)QLQVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RVEYFVDKQLQVK 13 2 A6NED2;G3V2I3 A6NED2 RCCD1 RCC1 domain-containing protein 1 1 29660700.0 3003800.0 9314900.0 17342000.0 True False 3888478.313750089 8796517.62654482 14185933.94394652 1.0 2.2622005105285945 3.648196749299974 21.890774262144415 -6.969923142784014 0.2600163638343449 0.6109581825961411 5.340560312877925 0.9999817767728076 0.0046168423789113965 0.07632767082916041 0.009119393167486091 0.028929953706715913 0.1307677049563904 1.071708949089054e-07 6.969923142784014 4.729602130281784 RVFEK(ub)YGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RVFEKYGR 8 2 J3QL05;J3KP15;Q01130-2;Q01130;Q9BRL6-2;Q9BRL6 J3QL05 SRSF2;SRSF8 Serine/arginine-rich splicing factor 2;Serine/arginine-rich splicing factor 8 1 3398630.0 1218100.0 1291700.0 888830.0 True False 1179432.0822542286 1807482.5461265123 656018.7586715617 1.0 1.5325024419141637 0.5562157995717092 20.169660912516907 -6.758603393102896 1.6178194583091727 1.3098445072548506 0.5529038923590708 0.6852094217478568 0.2239285625984678 0.2852675346870676 1.4712529307053892 0.10922861531431755 0.26284720288376057 1.743398254762069e-07 6.758603393102896 -0.7569406148957798 RVGIVAWHPTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RVGIVAWHPTAR 12 1 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;F8W1H8;F8VUX3;F8VSA4;F8VRE9;F8VTT6;F8VVB7;F8VV53 Q9ULV4 CORO1C Coronin-1C;Coronin 0 10408400.0 3682200.0 2343400.0 4382800.0 False True 4827399.858475522 1993773.8545016549 3929309.898786247 1.0 0.413011955287102 0.8139598984922518 22.202814900964263 -10.072531406202502 6.06213590090903 1.0000009219866908 0.6134859268896963 0.5533846022194631 0.16368631237854753 2.039744824701693e-06 3.1224683172915084e-07 0.15848896712018037 0.05282953015367865 8.461913738814991e-11 10.072531406202502 -0.3865149950969945 RVGIVAWHPTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RVGIVAWHPTAR 12 1 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;F8W1H8;F8VUX3;F8VSA4;F8VRE9;F8VTT6;F8VVB7;F8VV53 Q9ULV4 CORO1C Coronin-1C;Coronin 0 4790780.0 1554400.0 547980.0 2688400.0 False True 1505056.4228355435 766791.271677949 1984227.3897287734 1.0 0.5094767611657411 1.3183740885876334 20.521386142301974 -6.7424954901569345 1.6771999294944075 0.7090044637499727 1.319151450563513 0.6163230380304501 0.20608884764665844 0.313279246655825 1.7312076736258413 0.09716422399593613 0.2378154634043603 1.8092746982028412e-07 6.7424954901569345 0.6101469868135402 RVGIVAWHPTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RVGIVAWHPTAR 12 1 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;F8W1H8;F8VUX3;F8VSA4;F8VRE9;F8VTT6;F8VVB7;F8VV53 Q9ULV4 CORO1C Coronin-1C;Coronin 0 9077400.0 3682200.0 3508300.0 1886900.0 False True 5043608.847713429 3353291.7056033304 1441253.0819253388 1.0 0.6648595890071014 0.28575829836184574 22.266024962487155 -7.299676873980325 0.323683720049964 1.0627712221711874 3.1313687479540624e-12 0.9998068625938799 0.004054864696667553 0.10374794858699375 0.023264680759112748 0.01264761488942672 0.04949762679534867 5.015602682933672e-08 7.299676873980325 -1.062771222168056 down RVGIVAWHPTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RVGIVAWHPTAR 12 1 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;F8W1H8;F8VUX3;F8VSA4;F8VRE9;F8VTT6;F8VVB7;F8VV53 Q9ULV4 CORO1C Coronin-1C;Coronin 0 3457970.0 1554400.0 1090700.0 812870.0 False True 1292552.4715957334 1084824.182613002 982837.3587137698 1.0 0.8392883124301496 0.7603848820933344 20.30179141773625 -13.999999997063162 0.09319802990908564 1.8121926449119266 0.5730905238680257 0.9998272033892487 0.0013106279064234888 12.135577008237739 0.08946802583595585 1.9324403520456437 0.16782129517083683 1.0000000067623202e-14 13.999999997063162 -1.2391021210439008 RVGIVAWHPTAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RVGIVAWHPTAR 12 1 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;F8W1H8;F8VUX3;F8VSA4;F8VRE9;F8VTT6;F8VVB7;F8VV53 Q9ULV4 CORO1C Coronin-1C;Coronin 0 33138500.0 7005500.0 11983000.0 14150000.0 False True 9068757.849049946 11316135.516096428 11574845.1912607 1.0 1.2478153793997178 1.2763429550027399 23.112473527163022 -12.690413097093908 0.3253765727458695 2.0823379425794647e-09 1.2819176309311016 0.9996279089550929 0.002393705533886844 8.039426164844778 0.17833568893986607 5.363145465352451 0.009303306736487603 2.039796784836082e-13 12.690413097093908 1.2819176288487637 RVIISAPSADAPMFVMGVNHEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RVIISAPSADAPMFVMGVNHEK 22 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 43093700.0 18133100.0 9161600.0 15799000.0 False True 23772669.701190185 7794724.991637099 14164271.034709314 1.0 0.3278859753495357 0.5958216394181498 24.50280059308683 -10.359300130605117 5.856896441433372 1.0000951453322202 0.4618538073840029 0.8432285202007113 0.10938427681031494 0.00013592130760870522 1.4868873504027921e-05 0.10592941953155126 0.03530362353527383 4.3721984847257495e-11 10.359300130605117 -0.5382413379482174 RVIISAPSADAPMFVMGVNHEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RVIISAPSADAPMFVMGVNHEK 22 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 35690300.0 15036600.0 7906600.0 12747100.0 False True 14559271.363618702 11063746.612374315 9408252.105197027 1.0 0.7599107356444261 0.6462034994901428 23.795434820132915 -13.999999999999964 0.09937126124196859 2.187909334117111 0.40164118980943203 0.9997968622767125 0.002101922979058928 12.085289513286522 0.09375094264455906 2.948793276499841 0.21819781044653502 1.0000000000000819e-14 13.999999999999964 -1.786268144307679 RVIISAPSADAPMFVMGVNHEK ddPTM_RPMI8226_Bortezomib_8h_R1 2 RVIISAPSADAPMFVMGVNHEK 22 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 362787600.0 93194600.0 158677500.0 110915500.0 False True 141383021.63788357 130360260.3720339 88993002.80900927 1.0 0.9220361742297342 0.6294461794496236 27.075033639716374 -6.946341796312367 0.5976667289271669 1.003313244545343 0.5332514422212309 0.998881956074635 0.0053336338361792855 0.08498900548720616 0.04230563092711259 0.005486797282693623 0.024569959012997942 1.1315094976658921e-07 6.946341796312367 -0.4700618023241121 RVIISAPSADAPMFVMGVNHEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RVIISAPSADAPMFVMGVNHEK 22 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 59600800.0 18133100.0 22956000.0 18511700.0 False True 24837397.098602027 21941728.01465954 14139617.720428886 1.0 0.8834149539725533 0.5692874202677516 24.56601065460972 -6.953837872639332 0.5149920588056961 1.0055520388258126 0.4332512995121326 0.9994690536583731 0.004191336325761302 0.08198031538790924 0.0298606693129853 0.00478701828589841 0.025935338154108464 1.1121468276010577e-07 6.953837872639332 -0.57230073931368 RVIISAPSADAPMFVMGVNHEK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 RVIISAPSADAPMFVMGVNHEK 22 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 338439600.0 93194600.0 167543000.0 77702000.0 False True 120642246.84020695 158219084.76786625 63561033.28984726 1.0 1.3114732932438715 0.5268555166585641 26.846159961808823 -6.798960178603195 1.459927163904962 1.1720757518062321 0.5162697773994646 0.8292006770047494 0.13331443770403698 0.222223913274355 0.9351616620726201 0.07183871015322299 0.1671941942589186 1.5886924125499648e-07 6.798960178603195 -0.6558059744067676 RVLGLVLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RVLGLVLLR 9 1 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 57553000.0 18520000.0 18392000.0 20641000.0 False True 24279899.34793513 15647985.291454488 18505267.32245297 1.0 0.6444831202640575 0.7621640871434148 24.53325910514056 -10.870504792610822 10.70860359437019 1.0121778368595715 0.7033236037037363 0.894448789974746 0.048043053548632086 0.013339704751462145 0.00016131186495146597 0.044424928737818205 0.015505828857900262 1.3473958562178981e-11 10.870504792610822 -0.30885423315583527 RVLGLVLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RVLGLVLLR 9 1 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 70932000.0 29278000.0 19398000.0 22256000.0 False True 28348585.915966954 27143722.559233643 16426485.934311718 1.0 0.9574982907329185 0.5794463957745323 24.756773436666414 -6.928178931060952 0.7615959940364974 1.006154320047059 0.5053160419762354 0.9961679605638749 0.011701682158055088 0.09359470098022807 0.08239521604936302 0.010547481823725708 0.03455612088246519 1.1798344390004461e-07 6.928178931060952 -0.5008382780708237 RVLGLVLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RVLGLVLLR 9 1 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 208108000.0 28991000.0 62917000.0 116200000.0 False True 43981466.52599922 51688969.77723532 93233019.06773078 1.0 1.1752443440393214 2.11982515436626 25.39039237469164 -6.938145004909344 0.6766079380249068 0.9889801482928454 2.361218711095921 0.9979106072870091 0.0224808735031667 0.08862329251448522 0.05854200294759142 0.021587238730100537 0.0819848922410571 1.1530682000483977e-07 6.938145004909344 1.3722385628030755 up RVLGLVLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RVLGLVLLR 9 1 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 104093000.0 18520000.0 42189000.0 43384000.0 False True 25367344.484181404 40324950.479633644 33137592.721526794 1.0 1.5896401968593725 1.3063090912882414 24.59646916666345 -10.00692182442663 4.350339307348919 0.9999795210504434 1.4479746440692816 0.769221915970038 0.11566943982589784 80404553.47785725 208265547.4732714 27376.412834949224 0.04233069958611711 9.841882495185391e-11 10.00692182442663 0.44799512301883815 RVLGLVLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RVLGLVLLR 9 1 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 55218000.0 29278000.0 12267000.0 13673000.0 False True 24345954.23531901 12200915.236191148 16531961.0831909 1.0 0.5011475466626447 0.679043463377901 24.53717871210069 -10.181701452492753 6.3029603778399625 1.0000028508775751 0.5900955050202723 0.8762223605846978 0.07262570387950809 2.909479365884353e-06 3.777164487786349e-07 0.07032002463032987 0.02343984513599342 6.58110087193824e-11 10.181701452492753 -0.4099073458573028 RVLGLVLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RVLGLVLLR 9 1 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 285071000.0 28991000.0 133740000.0 122340000.0 False True 37529420.998045415 126297251.43309155 100075375.31440535 1.0 3.365286435931673 2.6665845795920333 25.16151869678409 -10.111939080142852 5.419572610100605 0.9999689858311618 3.015935507762692 0.9173527938575738 0.28524383839753403 0.00010689444198648987 1.7516307604509674e-05 0.27619036370600225 0.09206205297640073 7.727889790413345e-11 10.111939080142852 2.0159665219315306 RVLIAAHGNSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RVLIAAHGNSLR 12 1 P18669;P15259 P18669 PGAM1;PGAM2 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2 0 16728600.0 0.0 5819600.0 10909000.0 False True 0.0 5495734.144160459 8923673.935792442 0.0 RVNALK(ub)NLQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RVNALKNLQVK 11 2 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 5737140.0 901940.0 1926700.0 2908500.0 True False 873308.4083969959 2696041.357607767 2146676.596870313 1.0 3.0871583643131233 2.4580967917286545 19.736131705256742 -10.018487876202883 5.225931667836232 0.9999868385962819 2.7726275780267486 0.913699019152631 0.2568133116245862 3.9381432889239714e-05 7.395915658857925e-06 0.24866026224457347 0.08288613991425196 9.583234685623192e-11 10.018487876202883 1.7726407394304666 RVNQAIWLLCTGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RVNQAIWLLCTGAR 14 1 M0R0F0;P46782;M0R0R2;M0QZN2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 0 20144200.0 7828300.0 6514100.0 5801800.0 False True 10262977.10936504 5542221.671762927 5201485.390795388 1.0 0.5400208548361284 0.5068203246842473 23.290945956354946 -13.999999999999998 0.3731016669060074 7.533452461618953 0.5035444256283848 0.9997961621069192 0.003213362506851305 23.18655246654882 0.19854585280079376 121.32373230276059 0.009189816711762574 1.0000000000000041e-14 13.999999999999998 -7.029908035990569 RVNQAIWLLCTGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RVNQAIWLLCTGAR 14 1 M0R0F0;P46782;M0R0R2;M0QZN2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 0 55123000.0 10601000.0 12677000.0 31845000.0 False True 16082492.036912078 10414690.30414693 25550821.791840687 1.0 0.6475793851004825 1.5887352366285752 23.93898763855999 -6.805256835746095 1.4341350711891203 0.8068321110750472 1.6035132969344812 0.8471585625927892 0.15178281945846434 0.21332878076478848 0.8655589261619754 0.08323673690109268 0.19301148302520918 1.565824789130512e-07 6.805256835746095 0.796681185859434 RVNQAIWLLCTGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RVNQAIWLLCTGAR 14 1 M0R0F0;P46782;M0R0R2;M0QZN2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 0 23717000.0 7828300.0 8949000.0 6939700.0 False True 10722634.061852982 8553603.589614399 5300685.787607852 1.0 0.7977147723472946 0.49434548983310533 23.354156017877838 -6.9652604592957434 0.3535542309439616 1.028143725534662 0.2536236475776096 0.9999184129478701 0.00187698302291074 0.07787269162874239 0.014548956093586675 0.004128095491808666 0.02601512183969522 1.0832770457593455e-07 6.9652604592957434 -0.7745200779570524 down RVNQAIWLLCTGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RVNQAIWLLCTGAR 14 1 M0R0F0;P46782;M0R0R2;M0QZN2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 0 80440000.0 10601000.0 35159000.0 34680000.0 False True 13723203.476950768 33202370.742755126 28368595.84684954 1.0 2.419432955178519 2.0671992435656072 23.71011396065244 -10.46239821209625 5.654898768510105 0.998866302453341 2.2433160993720427 0.9432227621740571 0.14379881060971855 0.002056743592876531 0.00019553073812833395 0.13932892668257782 0.04641086655798869 3.44827416135388e-11 10.46239821209625 1.2444497969187016 RVPFSLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 RVPFSLLR 8 1 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 13012200.0 6997700.0 2260100.0 3754400.0 False True 9174052.4658232 1922901.8898008005 3365930.7027478083 1.0 0.2096022337962786 0.3668968228912106 23.12912772744892 -10.117058506718491 7.540674081628281 1.0000001564421057 0.28824952853400343 0.9646646285814582 0.0642152470972218 1.688693187916263e-07 1.972009316499834e-08 0.06217615907877291 0.020725381881677857 7.637328890741962e-11 10.117058506718491 -0.7117506279081023 RVPFSLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 RVPFSLLR 8 1 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 39158000.0 10994000.0 15712000.0 12452000.0 False True 16678701.769060584 12908070.84158368 9990856.742094513 1.0 0.7739253942131443 0.5990188493344132 23.991503661373645 -6.973990281022183 0.13164925123960294 1.2644261195952056 0.10398564411997356 0.9999991756746192 0.0001489179263229711 0.07502791719525856 0.0039577839472010965 0.01080775035338574 0.023699074238857074 1.0617193169089176e-07 6.973990281022183 -1.160440475475232 RVPFSLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RVPFSLLR 8 1 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 27053000.0 6997700.0 17263000.0 2792300.0 False True 9584938.795731977 16500263.578892969 2132816.2492236556 1.0 1.7214782410754963 0.22251746147543114 23.192337788971813 -6.775773722123733 1.5520385983071177 1.4107329116960927 0.2120966558653104 0.7523420491219115 0.30460834636545014 0.2571453484163125 1.2230843856438312 0.15462353560699102 0.3662017443360335 1.6758157889565299e-07 6.775773722123733 -1.1986362558307824 RVPFSLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RVPFSLLR 8 1 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 77562000.0 10994000.0 21296000.0 45272000.0 False True 14231949.724138914 20110858.879311472 37032960.52994737 1.0 1.4130782689037538 2.602100291791749 23.762629983466095 -6.95237720186526 0.5321121580220277 0.981527109083666 3.0878232628375146 0.9993748418256864 0.01698075392669787 0.08254510277083764 0.032119542861844874 0.018886083504085223 0.09835318796879308 1.1158936291913136e-07 6.95237720186526 2.1062961537538487 up RVYATILNAGTNTDGFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 RVYATILNAGTNTDGFK 17 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 17270600.0 5236500.0 5511500.0 6522600.0 False True 6865102.210338132 4689205.683658739 5847703.921197216 1.0 0.6830496531569888 0.851801436021037 22.71084976926687 -10.151922430340313 4.821739251377884 1.0000189388238485 0.7674255445878534 0.7169221075163861 0.06889262687097163 1.4027062775444846e-05 2.467246991772034e-06 0.06671042807288438 0.022234999711744693 7.048189459602785e-11 10.151922430340313 -0.23259339423599512 RWEQELNAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 RWEQELNAKR 10 2 O43463;O43463-2 O43463 SUV39H1 Histone-lysine N-methyltransferase SUV39H1 1 29736200.0 7367400.0 13671000.0 8697800.0 True False 9658732.746003097 11631340.089140613 7797835.091188974 1.0 1.2042304508273929 0.8073352163528714 23.203402484990995 -6.766817449738717 1.5864452923773051 1.1176142810925 0.8053558774758843 0.7183286324658054 0.0860068546065599 0.2715969153695555 1.3484879286357754 0.042743616780983706 0.1020553933709493 1.7107342497575158e-07 6.766817449738717 -0.3122584036166157 RWEQELNAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 RWEQELNAKR 10 2 O43463;O43463-2 O43463 SUV39H1 Histone-lysine N-methyltransferase SUV39H1 1 57212000.0 18387000.0 15653000.0 23172000.0 True False 17803314.749534953 21903324.52931663 17102558.054900754 1.0 1.2302947421568657 0.960638976252863 24.08564254177953 -6.680564519302638 1.9001037147917783 1.1456375564264418 0.9616660678732819 0.326636270978795 0.09759249603776994 0.4372554919390071 3.0527425878603047 0.04120794918414695 0.10859583557275186 2.0865821157767164e-07 6.680564519302638 -0.18397148855315992 RWEQELNAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 RWEQELNAKR 10 2 O43463;O43463-2 O43463 SUV39H1 Histone-lysine N-methyltransferase SUV39H1 1 76148000.0 20921000.0 22427000.0 32800000.0 True False 31738686.529972397 18424726.62704923 26317065.623249274 1.0 0.5805132045918112 0.8291794179446204 24.91973908930005 -10.27407905529173 5.679198687967931 1.0000222535313885 0.7048463112682117 0.6525918293484894 0.10151755649742121 2.8606326017217058e-05 3.6563551004289214e-06 0.09830135473161583 0.03276465047184642 5.3201140759819896e-11 10.27407905529173 -0.2951759422631768 RWEQELNAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 RWEQELNAKR 10 2 O43463;O43463-2 O43463 SUV39H1 Histone-lysine N-methyltransferase SUV39H1 1 24596900.0 7367400.0 10350000.0 6879500.0 True False 10091326.87649882 9892702.777126938 5254703.78774994 1.0 0.9803173455975895 0.5207148526708963 23.266612546513887 -6.9158875271436 0.8546637957899305 1.011720133391111 0.45318208063330007 0.9929603483966521 0.018579714632407315 0.10065254651883025 0.11859720323278004 0.015668978430292423 0.04523993737437111 1.2137031325683948e-07 6.9158875271436 -0.558538052757811 RWEQELNAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RWEQELNAKR 10 2 O43463;O43463-2 O43463 SUV39H1 Histone-lysine N-methyltransferase SUV39H1 1 60634000.0 18387000.0 30532000.0 11715000.0 True False 15289605.182212263 30367518.05587248 14164552.335960032 1.0 1.9861544947675742 0.9264171420488279 23.866047817213808 -6.662359841546183 1.96477132937773 1.633544583388414 0.9308365762973335 0.2456126045486704 0.41964754009012023 0.47885062235934067 3.5560288028283145 0.17242278323314764 0.46525613183733194 2.1759061438724428e-07 6.662359841546183 -0.7027080070910804 RWEQELNAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RWEQELNAKR 10 2 O43463;O43463-2 O43463 SUV39H1 Histone-lysine N-methyltransferase SUV39H1 1 61086000.0 20921000.0 26813000.0 13352000.0 True False 27082646.91456342 25320832.979478694 10922073.003089257 1.0 0.9349467597963134 0.40328676283173864 24.6908654113925 -6.929700617991801 0.7492468954463638 1.0081753957359132 0.2949677185657165 0.9964790483852415 0.015859922043152 0.09279362350519768 0.0784443173810694 0.01442349139920651 0.04818552192932091 1.1757077527879549e-07 6.929700617991801 -0.7132076771701967 down RWLPAGDALLQMITIHLPSPVTAQK ddPTM_RPMI8226_Bortezomib_8h_R1 2 RWLPAGDALLQMITIHLPSPVTAQK 25 1 P13639 P13639 EEF2 Elongation factor 2 0 6574635700.0 655164100.0 2144975000.0 3774496600.0 False True 993931838.611514 1762187452.4838336 3028465692.5893736 1.0 1.7729459747919376 3.0469551079277513 29.88857167781916 -6.963643637977547 0.38061305522149996 0.9130888439268332 3.951908384466527 0.9998823986428315 0.009152361129228763 0.07842429169647173 0.016501684207818813 0.016569673557946328 0.10762108343185103 1.0873174602284751e-07 6.963643637977547 3.038819540539694 RWLPAGDALLQMITIHLPSPVTAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 RWLPAGDALLQMITIHLPSPVTAQK 25 1 P13639 P13639 EEF2 Elongation factor 2 0 21999500.0 12999900.0 6394600.0 2605000.0 False True 10809992.843217563 6360151.020571279 3149693.4558408763 1.0 0.5883584857839923 0.2913686902038114 23.365862232144604 -8.03829353784709 0.23545407786099384 1.2000752329513729 5.570408032498339e-09 0.9996767641368622 0.005223850685876442 0.0973395303726591 0.04390634952654033 0.07478351612937989 0.09958047136845653 9.156014297096107e-09 8.03829353784709 -1.2000752273809647 down RWLPAGDALLQMITIHLPSPVTAQK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 RWLPAGDALLQMITIHLPSPVTAQK 25 1 P13639 P13639 EEF2 Elongation factor 2 0 6143344000.0 655164100.0 2680498000.0 2807681900.0 False True 848122842.6651555 2531325929.9528885 2296712603.449097 1.0 2.9846218054903546 2.7079952194564982 29.65969799991161 -10.253700810044826 5.160529228039378 0.9997399807571945 2.846308512473933 0.9834426963416435 0.11293233084694262 0.0003378910899717969 4.88642835740035e-05 0.10936059332830413 0.036448753051295676 5.5756973220035336e-11 10.253700810044826 1.8465685317167386 RYDDPEVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 RYDDPEVQK 9 1 P38646;A0A3B3ITI4;D6RJI2 P38646 HSPA9 Stress-70 protein, mitochondrial 0 7227400.0 2404300.0 1035400.0 3787700.0 False True 2327976.81254728 1448840.6195396716 2795587.741435681 1.0 0.6223604168781842 1.2008658017417018 21.150645257901278 -6.730559407678988 1.7212071137317932 0.7728800564807792 1.2005559273470618 0.5618544745333844 0.15874369409077718 0.33518838735006173 1.9456645793474758 0.0730798424624908 0.18122677887272584 1.8596901565074954e-07 6.730559407678988 0.42767587086628267 RYEEIVK(ub)EVSTYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RYEEIVKEVSTYIK 14 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 72186700.0 11331000.0 9165700.0 51690000.0 True False 14668202.867402034 8655620.73770217 42282950.384188384 1.0 0.5900941523612303 2.8826265062202094 23.80618878858966 -6.8606759347158235 1.1824079658957805 0.7772151900667493 2.995035782867924 0.9544518870725205 0.21304040568151886 0.14610122094939776 0.3877680923899877 0.1404958736431234 0.3281923786369368 1.3782375094330748e-07 6.8606759347158235 2.2178205928011745 up RYLSPK(ub)YIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 RYLSPKYIK 9 2 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 10874700.0 1694700.0 1838300.0 7341700.0 True False 2193822.5575312166 1735996.9890044283 6005585.932203443 1.0 0.791311486448569 2.737498487098124 21.06501541059751 -6.880360956413911 1.0777381660114125 0.8700174673185029 2.8764072083641525 0.9739773837108537 0.14073513832322435 0.12731293320718687 0.2703329514500729 0.10055552428189596 0.24340283332891477 1.3171615472536383e-07 6.880360956413911 2.0063897410456497 up RYQK(ub)STELLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 RYQKSTELLIR 11 2 Q71DI3;Q16695;P68431;Q6NXT2;Q5TEC6;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 Q71DI3;Q5TEC6;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;HIST2H3PS2;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 1 2383770.0 626390.0 622280.0 1135100.0 True False 606505.5923185513 870759.649147331 837783.2577299265 1.0 1.435699291441961 1.3813281663689965 19.2101614222938 -10.53150001334504 6.132215425677798 0.9994526516635284 1.4085137289054785 0.9868884902178088 0.022196918861634767 0.00016631489921197415 1.2706397689955948e-05 0.021519579534496982 0.007164024757352384 2.94103360337496e-11 10.53150001334504 0.4090610772419502 SAAASNLSGLSLQEAQQILNVSK(ub)LSPEEVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAAASNLSGLSLQEAQQILNVSKLSPEEVQK 31 1 P57737-3;A0A0A6YYL4;I3L3T0;I3L0X9;I3L1U7;Q9Y3D7 P57737-3 CORO7;CORO7-PAM16;PAM16 Coronin-7;Coronin;Mitochondrial import inner membrane translocase subunit TIM16 1 11653200.0 6290200.0 3747100.0 1615900.0 True False 6090521.044081402 5243336.570868352 1192647.3140391046 1.0 0.8609011499867782 0.195820243523842 22.53813422529767 -6.940807478928359 0.6520079448948738 1.0073738612772476 0.012126780344625743 0.9982677656047989 0.014605875415121946 0.08740017355331642 0.052946500570638974 0.014306264431285683 0.05704159266433211 1.146020855491704e-07 6.940807478928359 -0.9952470809326218 down SAADDSEAK(ub)SNELTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAADDSEAKSNELTR 15 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 6429800.0 1767700.0 3064700.0 1597400.0 True False 2681730.136180494 2517780.3403896056 1281673.1898347076 1.0 0.9388641707161492 0.4779277275304649 21.35473263476091 -6.931216302614978 0.7367386869340543 1.00670264397524 0.3803002129523533 0.996771962504442 0.013240231360033501 0.09201115033308158 0.07462181414075945 0.01215095839248932 0.04143135906940634 1.1716116929407186e-07 6.931216302614978 -0.6264024310228867 down SAADSISESVPVGPK(ub)VR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAADSISESVPVGPKVR 17 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 229464500.0 63340500.0 95852000.0 70272000.0 True False 83040008.89027451 81551255.22816956 63000927.53662208 1.0 0.982071850882481 0.7586816087636598 26.307303262362463 -6.922859644614937 0.8032464421193145 1.0044400049412616 0.7201786936506106 0.9949386243622891 0.0078099109179452855 0.09651911138607533 0.09711370011979248 0.006832932735255015 0.02106211982000118 1.194374040159439e-07 6.922859644614937 -0.284261311290651 SAADSISESVPVGPK(ub)VR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAADSISESVPVGPKVR 17 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 357223000.0 124677000.0 121669000.0 110877000.0 True False 120719196.87973931 170252066.19545287 81834987.46129954 1.0 1.4103147684544182 0.67789539341306 26.84707987215142 -6.754685319568319 1.6324601947678967 1.23990486356432 0.675900040029426 0.6688849133429233 0.1724729771857347 0.29195024457806124 1.532082063471845 0.08341209691688117 0.20151964112732987 1.759197829141807e-07 6.754685319568319 -0.5640048235348939 SAADSISESVPVGPK(ub)VR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAADSISESVPVGPKVR 17 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 521794000.0 237966000.0 169027000.0 114801000.0 True False 361011819.6449219 138862811.23602134 92110532.03093432 1.0 0.38464893302552183 0.2551454745208367 28.42747083129158 -13.999999999999849 0.21904927881255987 4.697891331910418 0.1852395768518962 0.9994969579063835 0.0072878024490757734 12.973921423321935 0.14827539971407275 20.74240992365016 0.07212236803220526 1.0000000000003477e-14 13.999999999999849 -4.5126517550585215 SAADSISESVPVGPK(ub)VR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAADSISESVPVGPKVR 17 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 226364800.0 63340500.0 91568000.0 71456300.0 True False 86759194.5626507 87522222.98511681 54579793.628693305 1.0 1.0087947845333571 0.6290952089150627 26.370513323885355 -6.901597544657362 0.9511017906601639 1.0151020081347857 0.5879189778443151 0.987344796425931 0.019906678372553468 0.11023927111929531 0.1708571945998049 0.015649109606266393 0.04105308097993113 1.254302983653969e-07 6.901597544657362 -0.42718303029047056 SAADSISESVPVGPK(ub)VR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAADSISESVPVGPKVR 17 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 315152800.0 124677000.0 150850000.0 39625800.0 True False 103674449.62759973 150037341.1086193 47911371.57100169 1.0 1.4471968903385146 0.46213287596992414 26.627485147585695 -6.783254751515464 1.5229523505551346 1.2521411761810661 0.45348417254323886 0.7788222440774464 0.18939649277348258 0.2455450416551064 1.1250295142831617 0.09792513749243677 0.23046473447377425 1.6471958843216637e-07 6.783254751515464 -0.7986570036378273 down SAADSISESVPVGPK(ub)VR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAADSISESVPVGPKVR 17 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 508013900.0 237966000.0 213198000.0 56849900.0 True False 308051678.0111371 201333343.88389593 46503801.52923342 1.0 0.6535700281970775 0.15096103949010836 28.19859715338403 -7.428275405891172 0.4768141277307806 1.0169141912830262 9.128067306493372e-26 0.9980950888571324 0.015213348327322148 0.1124860584520299 0.05694878023709166 0.018175807467270395 0.06401133129511652 3.7301353792159686e-08 7.428275405891172 -1.0169141912830262 down SAAEEK(ub)AAQALSVQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAAEEKAAQALSVQDK 16 1 P41440;P41440-2 P41440 SLC19A1 Folate transporter 1 1 128889400.0 51913000.0 43218000.0 33758400.0 True False 68058445.72620712 36770042.86244455 30265404.601438764 1.0 0.5402715632144621 0.4446972639250933 26.02027086857503 -13.999999999999998 0.22078178113541969 3.783745211560535 0.3939557524516969 0.999498687535125 0.005427468175705638 13.02100040347657 0.14884688668084747 15.809780807770435 0.05262172505458796 1.0000000000000041e-14 13.999999999999998 -3.389789459108838 SAAEEK(ub)AAQALSVQDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAAEEKAAQALSVQDK 16 1 P41440;P41440-2 P41440 SLC19A1 Folate transporter 1 1 78685700.0 33805300.0 19783500.0 25096900.0 True False 32732169.255585708 27683154.7195896 18523268.99913854 1.0 0.8457476344885239 0.5659041065840013 24.9642058813382 -6.96190635296745 0.4076832915207812 1.0141384948011618 0.3871671397872359 0.9998344864759027 0.002311538670988696 0.07902710399493824 0.01866638983404698 0.0036015809174083594 0.023382649158249967 1.0916757093893903e-07 6.96190635296745 -0.626971355013926 SAAEEK(ub)AAQALSVQDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAAEEKAAQALSVQDK 16 1 P41440;P41440-2 P41440 SLC19A1 Folate transporter 1 1 157859300.0 70693000.0 57069000.0 30097300.0 True False 107246449.35057288 46884591.06786785 24148555.46288479 1.0 0.4371668372405413 0.2251688108008752 26.67635464375504 -12.29598490048207 0.1598854674246667 2.6106244599232404 6.41199176511177e-17 0.9995471178949584 0.00695790521469818 6.152049519384502 0.11039015357245875 3.4156980219389528 0.18563391752424488 5.058422487826997e-13 12.29598490048207 -2.6106244599232404 SAAEEK(ub)AAQALSVQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAAEEKAAQALSVQDK 16 1 P41440;P41440-2 P41440 SLC19A1 Folate transporter 1 1 106553900.0 51913000.0 29642800.0 24998100.0 True False 71106638.99607499 28333083.080368966 19094063.632030208 1.0 0.39845903955512396 0.26852715726142223 26.08348093009792 -13.999999999999977 0.21537139080676376 4.558042246229414 0.1958670124165711 0.9994936977658351 0.0071697804556884875 12.877824413925476 0.14705418217909 19.44057829133281 0.07416797927072317 1.0000000000000532e-14 13.999999999999977 -4.3621752338128434 SAAEEK(ub)AAQALSVQDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAAEEKAAQALSVQDK 16 1 P41440;P41440-2 P41440 SLC19A1 Folate transporter 1 1 79862500.0 33805300.0 33870400.0 12186800.0 True False 28110604.77871543 33687933.43245198 14735003.534603309 1.0 1.1984065692517418 0.5241795276407658 24.744611156772475 -6.827888286208554 1.3371862605629374 1.1061814050550296 0.5067883632757415 0.9016165630168134 0.08873853222991411 0.18342567266322551 0.6421570306519853 0.052114449821937456 0.11995329030713903 1.4863179194359495e-07 6.827888286208554 -0.5993930417792881 SAAEEK(ub)AAQALSVQDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAAEEKAAQALSVQDK 16 1 P41440;P41440-2 P41440 SLC19A1 Folate transporter 1 1 143071400.0 70693000.0 52833000.0 19545400.0 True False 91513482.06735955 49892797.106060416 15988337.752739727 1.0 0.5451961391801947 0.17471018905139385 26.44748096584749 -7.939832827907925 0.34397732172287293 1.0871325025749052 2.226279070504047e-23 0.9986954450277052 0.01219035166775903 0.10372184667273604 0.0661022871841221 0.04761717218261816 0.08484877110088931 1.1485956630080232e-08 7.939832827907925 -1.0871325025749052 down SAAEEK(ub)AAQALSVQDK(ub)GLGGLQPAQSPPLSPEDSLGAVGPASLEQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAAEEKAAQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQR 46 2 P41440;P41440-2 P41440 SLC19A1 Folate transporter 1 2 26939600.0 11269000.0 6913500.0 8757100.0 True False 10911271.763338737 9674096.603426225 6463352.802631251 1.0 0.8866149440004463 0.592355588131143 23.37931592900158 -6.954655763832829 0.505154783556417 1.0056387925719326 0.4605283089874027 0.9995178013550096 0.0037724245113838696 0.08166838830916527 0.028629315800931934 0.0043823426271655105 0.024279017849572905 1.1100543324192024e-07 6.954655763832829 -0.5451104835845298 SAAEEK(ub)AAQALSVQDK(ub)GLGGLQPAQSPPLSPEDSLGAVGPASLEQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAAEEKAAQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQR 46 2 P41440;P41440-2 P41440 SLC19A1 Folate transporter 1 2 31498600.0 11269000.0 12953000.0 7276600.0 True False 9370672.801346058 12883219.618030796 8798103.416802973 1.0 1.3748446767002873 0.9388977294713738 23.159721204435858 -6.679178469770772 1.9049835191485627 1.2373494678379093 0.9405759743907417 0.3202445654169598 0.15889781497720865 0.4403776176727969 3.0891314424374334 0.06695050081244057 0.17675204528808158 2.0932520742337572e-07 6.679178469770772 -0.29677349344716764 SAAETVTK(ub)GGIMLPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAAETVTKGGIMLPEK 16 1 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 1 11095000.0 2575000.0 3448500.0 5071500.0 True False 3333388.260838427 3256587.943524874 4148539.0379843595 1.0 0.9769602844601618 1.244541203532319 21.668557936386275 -6.885951386354185 1.0460681475632378 0.9841963073344728 1.2658071947756142 0.9781766244077426 0.017885980246839895 0.12248813314277267 0.24154568509002186 0.013092630458863174 0.03219795898870152 1.3003151233341823e-07 6.885951386354185 0.2816108874411414 SAALSEK(ub)LK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAALSEKLK 9 1 Q13535;Q13535-2;Q13535-3;A0A590UJ01 Q13535 ATR Serine/threonine-protein kinase ATR 1 7670990.0 1600000.0 912690.0 5158300.0 True False 2071231.5407151415 861897.9991810103 4219542.328627574 1.0 0.41612827066326913 2.037214210812316 20.98205740920306 -6.809279159763237 1.4175207855023455 0.6815244853884371 2.065120994275509 0.8579511413042932 0.252660592171087 0.20778239264169182 0.8230072968686348 0.14015645296627854 0.32432395401439557 1.5513894731317668e-07 6.809279159763237 1.3835965088870719 up SAAPSTLDSSSTAPAQLGKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAAPSTLDSSSTAPAQLGKK 20 1 Q9Y5M8;H7C4H2 Q9Y5M8 SRPRB Signal recognition particle receptor subunit beta 1 10803600.0 1826300.0 4423500.0 4553800.0 True False 1518649.368808086 4399669.727503995 5505978.525607748 1.0 2.897093837372798 3.6255758825548536 20.534357383025963 -9.421718701972866 0.2931265757389347 1.5039177511979734e-22 3.936968996710849 0.9987497942539559 0.03913139190522639 0.8099144439158535 0.11544261099427068 1.0620555535331846 0.2615905508163772 3.7868778616569716e-10 9.421718701972866 3.936968996710849 SAAQAAAQTNSNAAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAAQAAAQTNSNAAGK 16 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 44996300.0 2919300.0 21653000.0 20424000.0 False True 3827230.5705414135 18422456.80273293 18310720.400841985 1.0 4.813521543366755 4.784326437445781 21.867869387748005 -10.158076670095475 4.3017340765597325 0.9990931418349838 4.798923990648306 0.9999557063887169 0.011918852899110322 2102555.3614737573 3561553.7832285943 25022.771234599928 0.0043618534260408464 6.949016292296187e-11 10.158076670095475 3.799830848813322 SAAQAAAQTNSNAAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAAQAAAQTNSNAAGK 16 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 28617700.0 9568700.0 4871000.0 14178000.0 False True 9264946.856141577 6816015.701929432 10464356.469117165 1.0 0.7356777980233326 1.1294567180577533 23.1433512702825 -6.725852441273979 1.7383559299577844 0.8401994285661236 1.129049671369731 0.5398974987314623 0.11115596745710113 0.34408723608170033 2.0350533306664524 0.050713210428550676 0.12643645693858507 1.879955454231164e-07 6.725852441273979 0.28885024280360727 SAAQAAAQTNSNAAGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAAQAAAQTNSNAAGK 16 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 59928300.0 4785000.0 51399000.0 3744300.0 False True 7259194.830357906 42226446.86778002 3004237.4638150125 1.0 5.816960124997513 0.41385271149512487 22.79137810670927 -6.671591526892695 1.931746914175088 4.07046836042242 0.43558068757072665 0.28606736070301164 2.0454008309444083 0.45750309633132985 3.2929089470003263 0.851962757793946 2.271504553776323 2.1301415961761092e-07 6.671591526892695 -3.6348876728516935 SAAQAAAQTNSNAAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAAQAAAQTNSNAAGK 16 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 37260300.0 2919300.0 17988000.0 16353000.0 False True 3998644.10111613 17193230.68163861 12490758.200606827 1.0 4.299765182112485 3.1237484219013933 21.931079449270896 -9.798258471109639 11.73775561625943 0.9999999993547817 3.711756802006939 0.8763823628083555 0.48010683191302883 0.0 8.944134808985998e-18 0.46486144109989114 0.15495381369996367 1.5912614032109297e-10 9.798258471109639 2.7117568026521575 SAAQAAAQTNSNAAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAAQAAAQTNSNAAGK 16 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 13887400.0 9568700.0 3112700.0 1206000.0 False True 7956798.015284415 3095931.2672774214 1458169.0240860246 1.0 0.3890926050064823 0.18326078169698298 22.923756545716778 -12.533059831456779 0.17409301025350468 2.8480343273665873 5.357305331546351e-23 0.9994861529582112 0.007862073483073245 6.797111759736836 0.12020379936529996 4.544741434043997 0.15905442639826625 2.930489492633141e-13 12.533059831456779 -2.8480343273665873 SAAQAAAQTNSNAAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAAQAAAQTNSNAAGK 16 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 12458700.0 4785000.0 3115200.0 4558500.0 False True 6194276.826451214 2941836.3815191193 3728899.774159856 1.0 0.47492814156395036 0.601991140957159 22.56250442880172 -10.051817087688656 7.444245036589488 1.0000000403370144 0.5384596412606293 0.9462139730540075 0.05187325228348838 3.469689781229211e-08 4.423655741649243e-09 0.05022606504242718 0.016742020183963854 8.875297352611141e-11 10.051817087688656 -0.4615403990763851 SAAQAAAQTNSNAAGK(ub)QLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAAQAAAQTNSNAAGKQLR 19 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 5574100.0 1624600.0 2131900.0 1817600.0 True False 2129866.332648778 1813828.8300811127 1629532.187650336 1.0 0.8516162738838969 0.7650865984739011 21.022331461148138 -13.999999947598829 0.05916690040887744 1.9530159946342827 0.36653931058660305 0.9999563016663496 0.0006412216286843217 12.47266417903812 0.06187101818609921 1.7746317064304005 0.37421946314896815 1.0000001206581634e-14 13.999999947598829 -1.5864766840476796 SAAQAAAQTNSNAAGK(ub)QLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAAQAAAQTNSNAAGKQLR 19 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 10458800.0 2847500.0 4342100.0 3269200.0 True False 2757107.671142694 6075923.173752365 2412898.4461022597 1.0 2.2037308289937676 0.8751556826586407 21.394724178199464 -6.668153601866279 1.9442322726969599 1.7695584689702804 0.8806008784081493 0.270810299128899 0.5115378920004112 0.46533882130698423 3.389484949889541 0.21196499522171616 0.5676194713841758 2.147070960831947e-07 6.668153601866279 -0.8889575905621311 SAAQAAAQTNSNAAGK(ub)QLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAAQAAAQTNSNAAGKQLR 19 1 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 1 12071200.0 2847500.0 7711100.0 1512600.0 True False 2367822.4156387323 7669558.773766488 1828877.6665277937 1.0 3.239076850996693 0.7723880196625491 21.17512945363374 -6.6677352166244015 1.9454941147989107 2.4319644737990638 0.7824674706200719 0.26904287497986434 0.9516094475610481 0.46631997865440056 3.4005649367351496 0.3940968704385796 1.0560118197812423 2.149140376119557e-07 6.6677352166244015 -1.649497003178992 SAATLITHPFHVITLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAATLITHPFHVITLR 16 0 Q9Y6C9;E9PIE4 Q9Y6C9 MTCH2 Mitochondrial carrier homolog 2 0 9520000.0 1951200.0 2038400.0 5530400.0 False True 2672611.3691973393 1948336.7479126146 4224233.422163273 1.0 0.7290011448607117 1.5805640396687866 21.349818636424672 -6.821108226896897 1.3671015615244109 0.8540961557508565 1.5995960954101098 0.8869099956909077 0.1194576423216881 0.192043253709048 0.7049639632280077 0.06866096276598105 0.15820533006110885 1.5097038865992134e-07 6.821108226896897 0.7454999396592533 SAATSGAGSTTSGVVSGSLGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAATSGAGSTTSGVVSGSLGSR 22 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 6395700.0 1280200.0 2200600.0 2914900.0 False True 1678354.5974744342 1872279.0578716155 2613294.109695178 1.0 1.1155443913276708 1.5570571997286082 20.67861612537127 -6.9459271631253925 0.6019085292039477 0.9950471337516601 1.7002295155801177 0.9988415834398242 0.008170072827603994 0.0851637643877487 0.04305836521461094 0.008369593335259487 0.037126776126025524 1.1325902975396223e-07 6.9459271631253925 0.7051823818284576 SACGVCPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SACGVCPGR 9 0 P49207 P49207 RPL34 60S ribosomal protein L34 0 14591900.0 1746000.0 7606200.0 5239700.0 False True 2289022.9082880532 6471384.608735383 4697546.106751466 1.0 2.8271384201983776 2.05220580787666 21.1263004706224 -10.608653208385952 6.1471263806028045 0.9943427495598867 2.439672114037519 0.821489430768409 0.31636491420503665 0.024467201213996127 0.0015576617271845635 0.3055558293800838 0.10210633700337042 2.4623330346106118e-11 10.608653208385952 1.4453293644776322 SACGVCPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SACGVCPGR 9 0 P49207 P49207 RPL34 60S ribosomal protein L34 0 12198100.0 1746000.0 5756200.0 4695900.0 False True 2391543.3838758497 5501872.050792089 3586825.1350962957 1.0 2.3005528931177035 1.4997951361782595 21.18951053214529 -10.100691304260687 5.338248986152523 0.9999857572879923 1.9001740146486223 0.627554852488289 0.32690798534845067 5.541502364762305e-05 9.33458729983362e-06 0.3165322901933426 0.1055090985827397 7.93064839252495e-11 10.100691304260687 0.90018825736063 SACK(ub)EDIPSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SACKEDIPSEK 11 1 B1AKZ5;Q15121;Q15121-2 B1AKZ5 PEA15 Astrocytic phosphoprotein PEA-15 1 7506220.0 623320.0 1554300.0 5328600.0 True False 945622.010795965 1276923.0211986701 4275399.874391649 1.0 1.3503524734199417 4.521256723701775 19.8509040912727 -6.9278759489856725 0.7640277074588987 0.9477898964604085 5.138357586565708 0.9961040337789377 0.0988589262828862 0.09375586234919003 0.08319450831148309 0.08895240681790276 0.2903354183580031 1.1806578282519876e-07 6.9278759489856725 4.1905676901053 up SACK(ub)EDIPSEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SACKEDIPSEK 11 1 B1AKZ5;Q15121;Q15121-2 B1AKZ5 PEA15 Astrocytic phosphoprotein PEA-15 1 3890920.0 623320.0 1017100.0 2250500.0 True False 806900.0274741008 960497.4908972443 1840932.0920800176 1.0 1.190355010773715 2.2814872095652596 19.62203041336515 -6.9368099593597625 0.6886077098122071 0.9868173685307323 2.550021880042741 0.9977154187372544 0.026986612457602355 0.08925264284431152 0.061467202658039705 0.025673116309702208 0.095306130002832 1.1566182499756758e-07 6.9368099593597625 1.5632045115120086 up SADLYK(ub)DR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SADLYKDR 8 1 Q9HBM1 Q9HBM1 SPC25 Kinetochore protein Spc25 1 1436070.0 432010.0 414450.0 589610.0 True False 566369.2935907914 352615.6755134467 528602.8131384869 1.0 0.6225896769188475 0.9333182768210043 19.11138352448845 -9.980467917959325 6.714159930408599 1.0000000317060065 0.7779539768699246 0.405068927535151 0.12685441970828978 6.024152368683536e-08 9.13197266017185e-09 0.12282628111813548 0.04094208791025036 1.0460009574034671e-10 9.980467917959325 -0.22204605483608186 SADLYK(ub)DR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SADLYKDR 8 1 Q9HBM1 Q9HBM1 SPC25 Kinetochore protein Spc25 1 2484240.0 651320.0 1353500.0 479420.0 True False 541601.4383683307 1346208.4268512866 579664.5054123729 1.0 2.485607185436906 1.0702787406893044 19.04687204481963 -6.634697320058428 2.062616480421907 1.9752921625505568 1.075950172271526 0.13504496003122113 0.6364739131348989 0.5467810740332074 4.438703701970181 0.25180409055504244 0.7052691912072597 2.3190103125946984e-07 6.634697320058428 -0.899341990279031 SADTLWDIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SADTLWDIQK 10 0 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 51245000.0 0.0 29137000.0 22108000.0 False True 0.0 24789873.17513646 19820476.234910645 0.0 SADTLWDIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SADTLWDIQK 10 0 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 51488200.0 16960000.0 8565200.0 25963000.0 False True 16421614.083434626 11985329.026927937 19162511.426695507 1.0 0.729850851812319 1.1669079135178175 23.96909260105455 -6.739510422364655 1.6886130122445067 0.8391713628860218 1.167131062174262 0.6027075882302364 0.11350616478345285 0.3186936106401739 1.7841277050300879 0.05318216052187954 0.13056816330617335 1.8217533534353165e-07 6.739510422364655 0.3279596992882403 SADTLWDIQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SADTLWDIQK 10 0 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 199082000.0 15071000.0 170280000.0 13731000.0 False True 22863808.837685272 139892203.5962874 11017061.831488905 1.0 6.118499528639781 0.48185592827954515 24.44656242356072 -6.667649671424373 1.9457198059930647 4.2737310580513554 0.5048600548594295 0.26867142262584287 2.1754191541377605 0.46652761430721884 3.402761144138652 0.9008233984483305 2.4141613887756677 2.149563744960327e-07 6.667649671424373 -3.7688710031919257 SADTLWDIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SADTLWDIQK 10 0 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 66731000.0 0.0 39887000.0 26844000.0 False True 0.0 38124660.45132973 20504000.069534022 0.0 SADTLWDIQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SADTLWDIQK 10 0 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 26310500.0 16960000.0 5750200.0 3600300.0 False True 14102991.455393469 5719222.531274667 4353106.084093626 1.0 0.40553258146429916 0.3086654415031109 23.749497876488828 -13.999999999999998 0.25532574988605405 5.247793180621601 0.27164336036020814 0.9995529505271429 0.006462217885633166 14.21553955134431 0.1598920044680456 31.068981247812072 0.04341806877372102 1.0000000000000041e-14 13.999999999999998 -4.9761498202613925 SADTLWDIQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SADTLWDIQK 10 0 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 0 41719000.0 15071000.0 12307000.0 14341000.0 False True 19509706.593823668 11622104.63127753 11731085.151086202 1.0 0.5957088373105942 0.6012948013682583 24.21768874565317 -10.145007746572965 5.758838609648888 1.000004785429907 0.5985018193396255 0.9998548456306197 0.002280460277206696 1.4011513813058464e-07 2.0802924253552414e-08 0.0022080724818751385 0.0007360153895984794 7.161306363741018e-11 10.145007746572965 -0.40150296609028147 SADTLWDIQK(ub)DLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SADTLWDIQKDLK 13 1 A0A5F9ZHM4;P07195 A0A5F9ZHM4 LDHB L-lactate dehydrogenase B chain 1 3218310.0 1454500.0 1023900.0 739910.0 True False 1906863.5853980372 871138.1111309399 663351.2109178908 1.0 0.4568434353677687 0.34787554600001624 20.862770208093266 -13.999999999999998 0.22582099091302305 4.363798223038074 0.29274287635043267 0.9995043803102438 0.006349735725670808 13.164593407021655 0.15049632233272975 19.809428252948525 0.05807217635279041 1.0000000000000041e-14 13.999999999999998 -4.071055346687642 SADTLWGIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SADTLWGIQK 10 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 45438000.0 5474000.0 22678000.0 17286000.0 False True 7176467.010291399 19294530.798151657 15497410.539020503 1.0 2.6885835008343757 2.159476315685207 22.774842346357914 -9.722596168166149 6.7506251808453035 0.9999999970547431 2.424029908260171 0.9061742435219666 0.21600710381066193 1.0898593500639976e-08 2.3083400935717784e-09 0.20914797892969028 0.06971599297656363 1.8941040462555477e-10 9.722596168166149 1.424029911205428 SADTLWGIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SADTLWGIQK 10 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 52681000.0 16538000.0 8894000.0 27249000.0 False True 16013010.24244351 12445420.581597269 20111669.447522443 1.0 0.7772068082870442 1.2559580705328706 23.932741205895695 -6.780166655097976 1.5352999973681727 0.8738776932511458 1.2597656886631903 0.7679685006107035 0.09422255009816438 0.2503070527536452 1.1654085896104172 0.048337375042323105 0.11403626820055954 1.6589501838083896e-07 6.780166655097976 0.38588799541204444 SADTLWGIQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SADTLWGIQK 10 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 145669000.0 17303000.0 118100000.0 10266000.0 False True 26249916.018742543 97024132.2804884 8236920.600252366 1.0 3.696169245311596 0.31378845533719696 24.64580947138887 -6.694355817602207 1.8508449063165184 2.6833537433936057 0.32478999129350883 0.39095100824317686 1.1392977829487232 0.4073609493134506 2.708795715767356 0.4918177186760052 1.273784372938588 2.021362397238235e-07 6.694355817602207 -2.358563752100097 SADTLWGIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SADTLWGIQK 10 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 47908000.0 5474000.0 23261000.0 19173000.0 False True 7497885.729287733 22233252.1061594 14644732.2803299 1.0 2.965269531824602 1.9531815779914647 22.838052407880806 -10.03419860335107 5.819419210069331 0.999996503064311 2.459225554908277 0.7348679506054053 0.4131831769523127 1.8747180230914965e-05 3.1121361689995083e-06 0.40006384970234615 0.13335429693898862 9.242754051053905e-11 10.03419860335107 1.4592290518439661 SADTLWGIQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SADTLWGIQK 10 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 28564500.0 16538000.0 8151800.0 3874700.0 False True 13752079.757623658 8107884.635394382 4684881.855411382 1.0 0.5895751608697342 0.3406671527493325 23.71314648132997 -8.771086977983753 0.17546839629604064 1.4058109980562346 8.822168629182935e-06 0.9997727525991345 0.004098065908715155 0.30412354365717487 0.05110823178962383 0.21268301676457077 0.14607212926191193 1.6939985022623616e-09 8.771086977983753 -1.4058021758876054 down SADTLWGIQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SADTLWGIQK 10 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 40613000.0 17303000.0 10285000.0 13025000.0 False True 22399074.593121324 9712630.70875838 10654583.647785915 1.0 0.433617499168519 0.4756707069968819 24.41693579348132 -10.563850337045384 6.183646831393469 1.0010956820128647 0.4546441030827005 0.9955601627103662 0.017168150204450724 0.0002597885890769526 1.8323581170812545e-05 0.016652317989180057 0.005540996652252088 2.729918382510549e-11 10.563850337045384 -0.5464515789301643 SADTLWGIQK(ub)ELQF ddPTM_RPMI8226_Bortezomib_8h_R1 1 SADTLWGIQKELQF 14 1 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 1 39555100.0 8839900.0 8905200.0 21810000.0 True False 13410774.583256207 7315997.483354831 17499243.940337423 1.0 0.5455313142381123 1.3048645200692437 23.676889231442722 -6.744580674018149 1.6698126185750253 0.731050777565352 1.305784799063321 0.6254603796507823 0.1909401678521385 0.30954563735265767 1.6963222141470924 0.09039800220550717 0.2207327618118352 1.8006086244916044e-07 6.744580674018149 0.5747340214979689 SAEAFGK(ub)IVAERPGTNSTGPAPMAPPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAEAFGKIVAERPGTNSTGPAPMAPPR 27 2 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 47045100.0 11240400.0 20388100.0 15416600.0 True False 14736273.252188446 17346274.952191368 13821438.11846948 1.0 1.1771140949503849 0.9379195052871929 23.81286838264825 -6.708342433167114 1.8008540032657943 1.1090666676595444 0.9385016332945837 0.45737099107381185 0.07465419352627112 0.37840319657718713 2.3910971028888377 0.03300055373935396 0.08401401114711665 1.9573007694577976e-07 6.708342433167114 -0.17056503436496073 SAEAFGK(ub)IVAERPGTNSTGPAPMAPPR ddPTM_RPMI8226_Bortezomib_2h_R1 2 SAEAFGKIVAERPGTNSTGPAPMAPPR 27 2 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 97927000.0 18356800.0 39246000.0 40324200.0 True False 17774073.432004303 54917132.46518636 29762082.319930498 1.0 3.0897325070291215 1.67446603806308 24.08327101787369 -10.480733481252095 6.194557490392724 0.9991607125195671 2.38209927254606 0.559776124737938 0.5777801165062145 0.006700213030181235 0.0005616530628274475 0.5596921532770477 0.18647773074986243 3.3057234513144575e-11 10.480733481252095 1.382938560026493 SAEAFGK(ub)IVAERPGTNSTGPAPMAPPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAEAFGKIVAERPGTNSTGPAPMAPPR 27 2 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 120938100.0 24498400.0 24599700.0 71840000.0 True False 37165863.87294467 20209691.33666666 57640792.51140938 1.0 0.5437702566461409 1.550906840439936 25.14747480621758 -6.783528868110096 1.5218779459916143 0.7428530962745721 1.5598198520590756 0.779744119675951 0.19324809334524656 0.24513640771393233 1.1215830331176984 0.09998496146573001 0.2352605401768875 1.6461565405592195e-07 6.783528868110096 0.8169667557845035 SAEAFGK(ub)IVAERPGTNSTGPAPMAPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAEAFGKIVAERPGTNSTGPAPMAPPR 27 2 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 48473700.0 11240400.0 14430000.0 22803300.0 True False 15396279.640388371 13792434.886371193 17417630.188705336 1.0 0.8958290709523173 1.1312882459613456 23.876078444171142 -6.786484714341351 1.510778540387639 0.9415109598369747 1.133540804794899 0.7895924641501798 0.04419046505700775 0.24063698730503752 1.0851448781835908 0.023030234996816803 0.054050823239102076 1.6349906961157937e-07 6.786484714341351 0.1920298449579242 SAEAFGK(ub)IVAERPGTNSTGPAPMAPPR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SAEAFGKIVAERPGTNSTGPAPMAPPR 27 2 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 68447300.0 18356800.0 35172600.0 14917900.0 True False 15264492.544125414 34983118.222585484 18037163.917423632 1.0 2.29179700022513 1.1816418963999749 23.863676293307968 -6.6093021459758035 2.1559769350957385 1.8634550432151487 1.1855672688006842 0.04825583165685832 0.5570344534958294 0.6146427154442508 5.41276787874837 0.21341634120479067 0.6185958439103577 2.4586564803203797e-07 6.6093021459758035 -0.6778877744144645 SAEAFGK(ub)IVAERPGTNSTGPAPMAPPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAEAFGKIVAERPGTNSTGPAPMAPPR 27 2 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 1 94889400.0 24498400.0 20367000.0 50024000.0 True False 31713661.735659875 19233558.545968134 40920145.289584816 1.0 0.6064754901620614 1.2903002381327942 24.91860112831003 -6.750627646544524 1.6473221683839856 0.7687826368230867 1.291741943795953 0.651762519612511 0.16536745426210914 0.2989447472881528 1.5962659624158269 0.07929084312694507 0.19238512267503924 1.7757112797949925e-07 6.750627646544524 0.5229593069728663 SAEAGIAGEAQSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAEAGIAGEAQSK 13 0 Q7Z478;A0A087WYN9 Q7Z478 DHX29 ATP-dependent RNA helicase DHX29 0 1269420.0 454770.0 814650.0 0.0 False True 596207.8739989441 693107.3954808282 0.0 1.0 1.1625264034705718 0.0 19.1854559032785 -6.930749978407829 1.2388143875823585 1.0869677263553659 2.166651920634314e-21 0.9644077378062502 0.09697320137823003 0.11655626837987763 0.35718547131972633 0.06463796673901452 0.12494053052814993 1.1728703880060331e-07 6.930749978407829 -1.0869677263553659 down SAEAILK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAEAILKR 8 1 Q9P2R3;Q9P2R3-2;Q9P2R3-4 Q9P2R3 ANKFY1 Rabankyrin-5 1 4178720.0 874220.0 1327100.0 1977400.0 True False 1146110.8859585237 1129101.852995283 1772797.6165601718 1.0 0.9851593478679721 1.5467941525374598 20.128315200577337 -6.900834006303781 0.9560099141921925 0.9771799989149268 1.6067495688243536 0.9869755752868967 0.029824119111030497 0.11079368344493944 0.17399150744867783 0.023360898679767848 0.061037362866974317 1.256510128455303e-07 6.900834006303781 0.6295695699094268 SAEAILK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAEAILKR 8 1 Q9P2R3;Q9P2R3-2;Q9P2R3-4 Q9P2R3 ANKFY1 Rabankyrin-5 1 6196400.0 758400.0 1630100.0 3807900.0 True False 734325.0071271723 2281007.4308591983 2810496.7554486664 1.0 3.1062641319855904 3.827319958016815 19.48605920561489 -9.494132249663751 0.31928622443308013 1.6142429653972335e-21 4.0651164966409095 0.9985955669942044 0.044953579392939806 0.8656188328711288 0.12875819632888313 1.1683240409006135 0.23465447748598345 3.2052931125050875e-10 9.494132249663751 4.0651164966409095 SAEAILK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAEAILKR 8 1 Q9P2R3;Q9P2R3-2;Q9P2R3-4 Q9P2R3 ANKFY1 Rabankyrin-5 1 13710000.0 1751800.0 4039900.0 7918300.0 True False 2657608.673734796 3318948.2811172344 6353244.534285827 1.0 1.2488476252800016 2.39058692014181 21.341697256321446 -6.941739590567116 0.6431749392655765 0.9874698651602629 2.714902943985628 0.9983830071555458 0.024346626768693362 0.0869818786846645 0.051062102261247334 0.024024541150135907 0.0975387874842376 1.1435638271384893e-07 6.941739590567116 1.727433078825365 up SAEAILK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAEAILKR 8 1 Q9P2R3;Q9P2R3-2;Q9P2R3-4 Q9P2R3 ANKFY1 Rabankyrin-5 1 4276320.0 874220.0 891500.0 2510600.0 True False 1197442.7589071854 852110.5822037366 1917647.987430045 1.0 0.7116086141615595 1.6014527401544738 20.191525262100228 -6.819454466132905 1.3742931377773397 0.8444744147799156 1.620643415509896 0.8831134384321224 0.126735946196583 0.1941899319314859 0.7208265276065072 0.07247204760578821 0.16705626826144004 1.515463685074344e-07 6.819454466132905 0.7761690007299805 SAEAILK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAEAILKR 8 1 Q9P2R3;Q9P2R3-2;Q9P2R3-4 Q9P2R3 ANKFY1 Rabankyrin-5 1 7338700.0 758400.0 3155200.0 3425100.0 True False 630643.2028166525 3138202.3113418333 4141272.5741269006 1.0 4.976193031694668 6.566744167907724 19.266464481049166 -8.969215350381052 0.37128045789910596 6.721954253179742e-24 6.951662391522084 0.9978115595813133 0.10952052661281407 0.44208732151278984 0.13239657086671447 1.1139534722442015 0.4294720871512122 1.073456993197649e-09 8.969215350381052 6.951662391522084 SAEAILK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAEAILKR 8 1 Q9P2R3;Q9P2R3-2;Q9P2R3-4 Q9P2R3 ANKFY1 Rabankyrin-5 1 16103300.0 1751800.0 2395500.0 11956000.0 True False 2267739.6331404913 2262188.3191862656 9780130.678919647 1.0 0.997552049682821 4.31272203210365 21.112823578413895 -6.906728364924328 0.9177286677647422 0.886436534830977 4.712469708505295 0.9896272401407449 0.1591059503069401 0.10662126812711414 0.1507977079184196 0.1281907825079097 0.3463338326783403 1.239571650167628e-07 6.906728364924328 3.826033173674318 up SAEAQK(ub)LGNGINIIVATPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAEAQKLGNGINIIVATPGR 20 1 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 1 10135300.0 1608000.0 2451700.0 6075600.0 True False 1556954.9201747007 3430676.5954465987 4484218.095906918 1.0 2.203452746763955 2.8801207008638112 20.57029574278292 -8.926375387663652 0.19961102055445892 1.483733022262892e-23 3.608790277166966 0.99959250848908 0.015695625729415977 0.41780427640751255 0.06431424931817427 0.6348084440505389 0.3632704823093718 1.1847442575041034e-09 8.926375387663652 3.608790277166966 SAEAQK(ub)LGNGINIIVATPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAEAQKLGNGINIIVATPGR 20 1 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 1 8077700.0 1608000.0 3870900.0 2598800.0 True False 1337123.2464783452 3850046.693386509 3142197.064506436 1.0 2.8793506533721467 2.3499681669451284 20.350701018217197 -10.192435194524705 4.984497414649532 0.9998476732265992 2.6146594101608818 0.9253953559976275 0.21611949509311726 0.00036587543825330186 5.927720066772502e-05 0.2092758848480535 0.0697522671060876 6.420440202469266e-11 10.192435194524705 1.6148117369342825 SAEEAYK(ub)QQIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAEEAYKQQIK 11 1 O15226;O15226-2 O15226 NKRF NF-kappa-B-repressing factor 1 10401200.0 1193100.0 1269600.0 7938500.0 True False 1544491.4695170233 1198945.6439319046 6493774.455888557 1.0 0.7762721048286695 4.204474148322244 20.55870047206734 -6.891314250393864 1.0145976003527117 0.8215597736064498 4.507012578714794 0.9817254711361196 0.21169742726214802 0.11808243902661984 0.2156815022249907 0.15870437059794124 0.39756282049725306 1.28435697798388e-07 6.891314250393864 3.685452805108344 up SAEEEAADLPTK(ub)PTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAEEEAADLPTKPTK 15 1 Q8WW12;Q8WW12-2 Q8WW12 PCNP PEST proteolytic signal-containing nuclear protein 1 8154800.0 2154500.0 4051700.0 1948600.0 True False 1791562.2105333295 4029872.6879005176 2356043.250691565 1.0 2.249362407962862 1.3150775545718814 20.77278671014865 -10.192545263846545 4.699476465597201 0.9998744795823523 1.7822199812719994 0.4831042697937732 0.3814201942190161 0.0005016924627747345 8.620140860066643e-05 0.369367081177591 0.12310283845523669 6.418813186740531e-11 10.192545263846545 0.7823455016896471 SAEEEAADLPTKPTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAEEEAADLPTKPTK 15 1 Q8WW12;Q8WW12-2 Q8WW12 PCNP PEST proteolytic signal-containing nuclear protein 0 6255650.0 1591400.0 914350.0 3749900.0 False True 1540881.8780883183 1279454.723272258 2767688.6954113706 1.0 0.8303392631624705 1.7961718771364095 20.555324840373572 -6.8615442769131585 1.1778199140864904 0.907536345696652 1.844360323831728 0.9554955127837405 0.08882393530519943 0.1452243326083296 0.3819323778583353 0.058778603127452415 0.1374623005239993 1.3754845706037055e-07 6.8615442769131585 0.9368239781350761 SAEEEAADLPTKPTK(ub)ISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAEEEAADLPTKPTKISK 18 2 Q8WW12;Q8WW12-2 Q8WW12 PCNP PEST proteolytic signal-containing nuclear protein 1 4170800.0 1236900.0 1281800.0 1652100.0 True False 1197635.286544829 1793629.4244986968 1219365.4480623822 1.0 1.497642433092722 1.0181442228378597 20.19175720332585 -10.502646493124098 4.367653762827641 0.9982655089376056 1.2578933279656075 0.27834091548386375 0.19575432461827286 0.003327451858321852 0.0003789030473670887 0.19075474902378337 0.06317943659938074 3.143066044758238e-11 10.502646493124098 0.2596278190280019 SAEFLLHMLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 SAEFLLHMLK 10 0 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 114780300.0 35971700.0 29452800.0 49355800.0 False True 47159247.050438285 25058557.04611521 44248935.270264246 1.0 0.5313604142007251 0.9382875689880847 25.491037348490398 -10.19628329865105 7.836240222871273 1.000000133480273 0.734823991594405 0.36151405792539326 0.16612731528526337 3.8740260498167356e-07 3.97633380734862e-08 0.16085216045871337 0.05361736045416451 6.363802623861106e-11 10.19628329865105 -0.265176141885868 SAEFLLHMLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAEFLLHMLK 10 0 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 83920100.0 29523000.0 19646600.0 34750500.0 False True 28585808.525073186 27491589.835665524 25648301.557346307 1.0 0.9617216113216494 0.8972389755864232 24.768795760451972 -6.963259485496914 0.38679916324989877 1.004104301382638 0.8525513365603536 0.9998725715489418 0.0004786420637110836 0.07855713052698987 0.016976836537487522 0.0008342382325533536 0.005431669209102354 1.0882796656133957e-07 6.963259485496914 -0.15155296482228442 SAEFLLHMLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAEFLLHMLK 10 0 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 56571600.0 14698800.0 23002400.0 18870400.0 False True 22299154.226220448 18897442.00142848 15140657.168809867 1.0 0.8474510651712491 0.6789789879567151 24.410485656115984 -6.969846632265963 0.2618216983767194 1.0462589887647784 0.47516081676544747 0.9999811604178468 0.0005690482952737707 0.0763524983551828 0.009207978857972506 0.003475948792902665 0.01585258214120406 1.0718977708068589e-07 6.969846632265963 -0.5710981719993309 SAEFLLHMLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SAEFLLHMLK 10 0 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 118907300.0 35971700.0 33193300.0 49742300.0 False True 49271409.58864077 31726710.250435565 37994193.21482579 1.0 0.6439172435965779 0.7711204841110355 25.55424741001329 -10.673220560813228 7.039386572333365 1.001464775491375 0.7075188638538067 0.8757636178167321 0.05193050548149093 0.0011990994547748295 5.5663985241734455e-05 0.05050484991262224 0.016760498574162265 2.1221664247506585e-11 10.673220560813228 -0.29394591163756834 SAEFLLHMLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAEFLLHMLK 10 0 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 61091000.0 29523000.0 11417500.0 20150500.0 False True 24549682.590659317 11355991.661303686 24363876.384614795 1.0 0.4625718324205309 0.9924314212471644 24.54920103588625 -10.94147033873664 10.238809776871904 1.0685630053227795 0.7275016268338614 0.26071093635830345 0.21631427132435854 0.11754661347162683 0.0006719488661027083 0.0727201252684521 0.06981513086551944 1.1442730282302342e-11 10.94147033873664 -0.34106137848891804 SAEFLLHMLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAEFLLHMLK 10 0 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 0 58902000.0 14698800.0 26609100.0 17594100.0 False True 19027886.356664814 25128280.19372125 14392154.330710951 1.0 1.320602810144474 0.7563716779120806 24.181611978208434 -6.752568299916871 1.6404049458708234 1.1879318746156378 0.7550302851813065 0.6599509605809624 0.1347395752857101 0.2955718221887306 1.5656401637183606 0.06486569326654892 0.15705005830761676 1.7677941812974245e-07 6.752568299916871 -0.4329015894343312 SAEFLLHMLK(ub)NAESNAELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAEFLLHMLKNAESNAELK 19 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 47617300.0 19564400.0 5351900.0 22701000.0 True False 18943338.831011146 7488941.579789793 16754927.084597863 1.0 0.3953337712320301 0.8844759223315612 24.175187297574222 -10.077554744896357 7.287633248205393 1.000000068229874 0.6399048467818156 0.4194850672809216 0.19969144698020025 2.21141638945854e-07 2.8465011156643885e-08 0.19335044670708898 0.06445013737786474 8.364601493079371e-11 10.077554744896357 -0.3600952214480584 SAEFLLHMLK(ub)NAESNAELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAEFLLHMLKNAESNAELK 19 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 78867000.0 29080000.0 30943000.0 18844000.0 True False 44116486.03277073 25420979.89123754 15119475.140381405 1.0 0.5762240417868788 0.3427171223281545 25.39481454614284 -9.506361170386828 0.15680887232906987 1.5826005872273134 2.690905339334217e-13 0.9997559628604036 0.0042499768283661525 0.9479394561635549 0.0619327354943785 0.4266644583225812 0.1799055309595515 3.11629691404685e-10 9.506361170386828 -1.5826005872270443 SAEFLLHMLK(ub)NAESNAELK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SAEFLLHMLKNAESNAELK 19 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 55610400.0 22162500.0 17084600.0 16363300.0 True False 18429100.7152216 16992561.868772414 19784790.374649156 1.0 0.9220505184356245 1.0735624423772245 24.135482337711682 -6.766815772184069 1.5862799661670448 0.955111177159543 1.074321860597533 0.7184266218869324 0.032826732433494515 0.27157766453613463 1.3480829318535372 0.016315431942635874 0.038957773370984036 1.7107408578445503e-07 6.766815772184069 0.11921068343799013 SAEFLLHMLK(ub)NAESNAELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAEFLLHMLKNAESNAELK 19 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 75217800.0 29080000.0 23136800.0 23001000.0 True False 37644633.25249766 21849216.74111826 18815054.01018994 1.0 0.5804072148762028 0.49980707433088334 25.16594086823529 -13.999999999999979 0.23197133502116796 3.673159271542828 0.4613464770777707 0.9995125482319565 0.004841294709645655 13.35348109847845 0.15248601015782545 16.45936405049091 0.04133163513522066 1.000000000000049e-14 13.999999999999979 -3.211812794465057 SAFAPFGK(ub)ISDAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAFAPFGKISDAR 13 1 Q01085;Q01085-2;E7ETJ9 Q01085 TIAL1 Nucleolysin TIAR 1 3661700.0 892800.0 1313300.0 1455600.0 True False 1222892.287012805 1255274.0634976637 1111817.259023012 1.0 1.0264796636864548 0.9091702276893745 20.221865905457676 -6.8474162899822 1.247592785089859 1.0141046778297884 0.9047118005311391 0.9364457625474124 0.012664427727822652 0.16032372465205239 0.48152158125817784 0.007948484068853304 0.018364394583429457 1.420966076880094e-07 6.8474162899822 -0.10939287729864933 SAFCSDK(ub)LDEYLENEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAFCSDKLDEYLENEGK 17 1 Q8IWI9-3;Q8IWI9;H3BP52;H3BTF4 Q8IWI9-3 MGA MAX gene-associated protein 1 13372900.0 6488200.0 4670000.0 2214700.0 True False 8506093.031818178 3973254.203517426 1985544.088902504 1.0 0.4671068360826689 0.2334260960320221 23.02006520324491 -10.430859762058995 0.18145819068695535 1.787669271538497 1.4415438851290705e-17 0.9995087836513928 0.0071100305598052775 2.1491690610670844 0.09204819993074936 0.9283387742803463 0.16126656577775736 3.708004375451602e-11 10.430859762058995 -1.787669271538497 SAFLAAHIPLFLYPFLHTVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAFLAAHIPLFLYPFLHTVSK 21 0 Q92600;Q92600-3;Q92600-2 Q92600 RQCD1 Cell differentiation protein RCD1 homolog 0 2679590000.0 846880000.0 1209860000.0 622850000.0 False True 1284778875.2212138 993951030.3206743 499743424.4951466 1.0 0.7736358757840996 0.3889723236686161 30.25887293085812 -6.963101494669115 0.389265873483922 1.0238187314080145 0.1249844260460121 0.9998684982386534 0.0028923761304015414 0.07861128439056987 0.01716948720708553 0.004968551964394895 0.032367333022633164 1.0886756399825731e-07 6.963101494669115 -0.8988343053620024 down SAFLAAHIPLFLYPFLHTVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAFLAAHIPLFLYPFLHTVSK 21 0 Q92600;Q92600-3;Q92600-2 Q92600 RQCD1 Cell differentiation protein RCD1 homolog 0 3547440000.0 846880000.0 1528320000.0 1172240000.0 False True 1096302854.500524 1443267648.4987473 958904348.1981237 1.0 1.3164862634206134 0.8746710311495092 30.02999925295057 -6.714411122161198 1.779281809734166 1.1936857796893852 0.8755598854357358 0.48607705398115786 0.1332778365475639 0.36629688908756425 2.2630806675149753 0.05954666814895736 0.150484141218863 1.930140296644092e-07 6.714411122161198 -0.31812589425364934 SAFLCGVMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAFLCGVMK 9 0 O60506;O60506-2;O60506-3;O60506-4;F6UXX1;O43390;O43390-3;O43390-2 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 42715400.0 8551400.0 11704000.0 22460000.0 False True 11210968.211875413 9957808.821834665 20136054.651533064 1.0 0.8882202351877765 1.796103090382827 23.418407543082093 -6.876077350442118 1.1013973539546507 0.9337344574340514 1.855804890522284 0.9703833110048822 0.06956381132539749 0.13116368031041636 0.29374058682307885 0.04881129998498691 0.11695206674820374 1.33021747719775e-07 6.876077350442118 0.9220704330882326 SAFLCGVMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAFLCGVMK 9 0 O60506;O60506-2;O60506-3;O60506-4;F6UXX1;O43390;O43390-3;O43390-2 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 9264100.0 4486100.0 2133800.0 2644200.0 False True 4343691.211066985 2985837.4676199993 1951604.6957003537 1.0 0.6873963462256697 0.4492963704988968 22.050490116274773 -7.5311244143493665 0.16696404031404277 1.2633445286462304 4.102198519406979e-11 0.9999747125963303 0.0011339909477854325 0.13205594522440545 0.01587004755600182 0.039315760915405236 0.06982836822814549 2.9435782525212622e-08 7.5311244143493665 -1.2633445286052083 down SAFLCGVMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAFLCGVMK 9 0 O60506;O60506-2;O60506-3;O60506-4;F6UXX1;O43390;O43390-3;O43390-2 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 33327200.0 8796200.0 14520000.0 10011000.0 False True 13344478.488358263 11928792.554722205 8032321.462022833 1.0 0.8939122323235709 0.601920971960818 23.66973958925223 -6.953369889504971 0.5205357150753863 1.004941234078955 0.47784948625014245 0.9994398895491419 0.003983534164182404 0.08216012986047395 0.030575677497371896 0.004508996141273893 0.0241199099511276 1.1133458906797045e-07 6.953369889504971 -0.5270917478288125 SAFLCGVMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAFLCGVMK 9 0 O60506;O60506-2;O60506-3;O60506-4;F6UXX1;O43390;O43390-3;O43390-2 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 31334400.0 8551400.0 11252000.0 11531000.0 False True 11713083.672895737 10754849.434611833 8807615.28839953 1.0 0.9181911215659396 0.7519467575204378 23.481617604604985 -6.959732177263089 0.4391927326077555 1.0059944701725116 0.657670470581303 0.9997601320569656 0.001598384990404983 0.07979693674217292 0.021485929750101468 0.002189655141576901 0.013776507893080039 1.097154585944734e-07 6.959732177263089 -0.34832399959120863 SAFLCGVMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAFLCGVMK 9 0 O60506;O60506-2;O60506-3;O60506-4;F6UXX1;O43390;O43390-3;O43390-2 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 25621300.0 8796200.0 10163000.0 6662100.0 False True 11386854.29902408 9597420.116004994 5449666.158918585 1.0 0.8428508755774233 0.47859277161258246 23.44086591134468 -6.95706109732681 0.47504477862756544 1.0091642046025933 0.29721912400108674 0.9996451909897917 0.004113660227284822 0.08076815097958448 0.02514079718434306 0.005085446667811643 0.030054775043439886 1.1039233070662807e-07 6.95706109732681 -0.7119450806015065 down SAFLLQNLLVGHPEHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAFLLQNLLVGHPEHK 16 0 Q9NZL4;Q9NZL4-3 Q9NZL4 HSPBP1 Hsp70-binding protein 1 0 37815400.0 9751400.0 14145000.0 13919000.0 False True 12784179.832691925 12034621.136778155 12478795.40047591 1.0 0.941368260950383 0.9761123172379756 23.607856271856964 -10.096622424884266 4.967113111646321 1.0000013438400452 0.9587402890939919 0.652815425132742 0.014184201583839044 2.110961901784066e-07 3.840173086664703e-08 0.013734241503280132 0.0045779313760286895 8.00529932341616e-11 10.096622424884266 -0.04126105474605335 SAFLLQNLLVGHPEHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAFLLQNLLVGHPEHK 16 0 Q9NZL4;Q9NZL4-3 Q9NZL4 HSPBP1 Hsp70-binding protein 1 0 37025800.0 12447000.0 6547800.0 18031000.0 False True 12051876.798143322 9162370.686325917 13308140.18159482 1.0 0.760244303836349 1.1042379875344424 23.522754494196796 -6.719291248364065 1.761800487559555 0.8540251920067803 1.103682574414921 0.5091839417276397 0.10089903903502453 0.3567046848319867 2.163416022797609 0.04547961337759763 0.1142689212216221 1.9085728942340063e-07 6.719291248364065 0.24965738240814073 SAFLLQNLLVGHPEHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAFLLQNLLVGHPEHK 16 0 Q9NZL4;Q9NZL4-3 Q9NZL4 HSPBP1 Hsp70-binding protein 1 0 35680000.0 10143000.0 13381000.0 12156000.0 False True 15387672.552627021 10993056.003769826 9753361.271835921 1.0 0.7144066762645702 0.6338425280677553 23.875271698950417 -13.999999999999995 0.17751588695495868 2.4707753818814884 0.5681777925074811 0.99950134410377 0.0035081468980673403 12.17363109376501 0.13353843651623343 6.172267343911875 0.06144658704476453 1.0000000000000123e-14 13.999999999999995 -1.9025975893740072 SAFLLQNLLVGHPEHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAFLLQNLLVGHPEHK 16 0 Q9NZL4;Q9NZL4-3 Q9NZL4 HSPBP1 Hsp70-binding protein 1 0 47536400.0 9751400.0 11784000.0 26001000.0 False True 13356756.10167637 11263343.915523088 19860099.30740404 1.0 0.8432694158508635 1.4868954075541931 23.671066333379855 -6.842343342389629 1.2714582830479866 0.9166327924238572 1.5090677769153502 0.9284144051330934 0.07332098632427961 0.16607532475941097 0.5205043206742437 0.045200003773852485 0.10420729906999268 1.4376615494843028e-07 6.842343342389629 0.592434984491493 SAFLLQNLLVGHPEHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAFLLQNLLVGHPEHK 16 0 Q9NZL4;Q9NZL4-3 Q9NZL4 HSPBP1 Hsp70-binding protein 1 0 29425300.0 12447000.0 9451200.0 7527100.0 False True 10350231.995594485 9400284.509683691 9100981.808621814 1.0 0.908219691470188 0.8793022042883284 23.303159769631073 -13.99999977591637 0.16166064250625944 1.4536278550986574 0.8513894398027809 0.999532087290954 0.0011130055632886317 12.021318702808037 0.12711602894248653 1.7097092990372267 0.025494403289145092 1.0000005159717588e-14 13.99999977591637 -0.6022384152958765 SAFLLQNLLVGHPEHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAFLLQNLLVGHPEHK 16 0 Q9NZL4;Q9NZL4-3 Q9NZL4 HSPBP1 Hsp70-binding protein 1 0 33239100.0 10143000.0 9641100.0 13455000.0 False True 13130313.448421046 9104564.30979197 11006328.059958495 1.0 0.6934003781064965 0.8382380286041103 23.646398021042867 -10.095140781495033 4.675587709446924 1.0000133931931166 0.7658192033514849 0.7770647032752558 0.05912972322613748 82279190.38636856 0.059740108985086526 12193.938694580738 0.020241677016388362 8.032656922684867e-11 10.095140781495033 -0.23419418984163165 SAFPFSDK(ub)LGELSDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAFPFSDKLGELSDK 15 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 93427000.0 38689000.0 40791000.0 13947000.0 True False 50721653.66480901 34705141.80207267 12503898.22907088 1.0 0.6842273327959594 0.2465199244429635 25.596098446264726 -7.239983243352247 0.38884261936317305 1.0335433521469701 2.9977316068121023e-15 0.9996610233413453 0.005688112603526889 0.09423368697337188 0.026735282195621494 0.009980290180941475 0.04682464384985835 5.7546214031407035e-08 7.239983243352247 -1.033543352146967 down SAFPFSDK(ub)LGELSDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAFPFSDKLGELSDK 15 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 170785000.0 106500000.0 38808000.0 25477000.0 True False 103119215.79515271 54304236.781046465 18803809.406382993 1.0 0.5266160759884204 0.18235019788879056 26.619737956491917 -8.113252750087263 0.315887370065686 1.121272518817487 3.358777627387273e-23 0.998875219325878 0.011241469734422692 0.09149023516213356 0.06818230853547996 0.0671418807625297 0.09103303047395443 7.704549502825544e-09 8.113252750087263 -1.121272518817487 down SAFPFSDK(ub)LGELSDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAFPFSDKLGELSDK 15 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 135007000.0 58927000.0 31509000.0 44571000.0 True False 89396567.14075245 25885972.769059315 35761522.31383673 1.0 0.2895633870180111 0.40003238891188286 26.41371609669282 -10.156388983873134 5.472259618058326 1.0000146149968892 0.3447978879789942 0.9791248489819115 0.045098781178444985 8.718787504648188e-06 1.3441786663637863e-06 0.04366776139738736 0.01455556903562614 6.976072993148196e-11 10.156388983873134 -0.655216727017895 SAFPFSDK(ub)LGELSDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAFPFSDKLGELSDK 15 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 74760000.0 38689000.0 20321000.0 15750000.0 True False 52993368.830912255 19423151.027439293 12030174.381432025 1.0 0.36652040540040776 0.2270128253181471 25.659308507787618 -13.999999999999995 0.21263086739718387 4.7038363084188735 0.14690843590284772 0.9994916515942776 0.007583861380496935 12.809568677848635 0.14613641105663353 19.84646827596991 0.08114023759035974 1.0000000000000123e-14 13.999999999999995 -4.556927872516026 SAFPFSDK(ub)LGELSDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAFPFSDKLGELSDK 15 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 173317000.0 106500000.0 47419000.0 19398000.0 True False 88559468.74996501 47163544.43506544 23454032.113781687 1.0 0.5325635429027353 0.2648393497029752 26.400143231926194 -8.859936058699699 0.20908531555515625 1.356207175592683 8.50843992748778e-13 0.9995568801271943 0.006395052347821127 0.3641693254287489 0.06464558950047603 0.22052962963470918 0.1313301158392965 1.3805875139332957e-09 8.859936058699699 -1.3562071755918321 down SAFPFSDK(ub)LGELSDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAFPFSDKLGELSDK 15 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 125636000.0 58927000.0 30544000.0 36165000.0 True False 76282163.12482566 28844199.549666125 29583341.084236324 1.0 0.37812508675804607 0.38781465905505463 26.18484241878527 -10.480446524179744 6.147770641615581 1.000394648779471 0.3829698729065505 0.999815082357274 0.003955751325579889 2.1410329114481202e-05 1.8094039010295005e-06 0.0038324691130058046 0.001276713250475713 3.3079084069674714e-11 10.480446524179744 -0.6174247758729206 SAFSCFHYSTEEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAFSCFHYSTEEIK 14 0 Q8N4Q1;Q8N4Q1-2 Q8N4Q1 CHCHD4 Mitochondrial intermembrane space import and assembly protein 40 0 11480600.0 3506400.0 3464600.0 4509600.0 False True 4596924.356025907 2947695.1849050224 4042989.851137734 1.0 0.6412320405144404 0.8794988862146395 22.132237495630253 -10.55400351816777 5.1219046280138265 1.0012450820305738 0.7603654633645376 0.5742297202576867 0.09727203243133145 0.0013898762001630651 0.00012102520609516115 0.09465217050517383 0.031394413471523365 2.7925212192645672e-11 10.55400351816777 -0.24087961866603624 SAFSGGYYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAFSGGYYR 9 0 Q96DA6-2;Q96DA6;A0A2R8Y817;F2Z3A7 Q96DA6-2 DNAJC19 Mitochondrial import inner membrane translocase subunit TIM14 0 7252900.0 2285200.0 1709400.0 3258300.0 False True 2995919.3299082806 1454364.1831890123 2921162.371820578 1.0 0.48544837929048557 0.9750470724156677 21.514567346689546 -10.704433847041763 9.923055785793823 1.0003148079494317 0.7302477258530766 0.2881303200579025 0.19987782948169708 0.0013936121433933718 4.150990677363075e-05 0.1937467129628198 0.06451029207155819 1.974995693402941e-11 10.704433847041763 -0.2700670820963551 SAFSGGYYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAFSGGYYR 9 0 Q96DA6-2;Q96DA6;A0A2R8Y817;F2Z3A7 Q96DA6-2 DNAJC19 Mitochondrial import inner membrane translocase subunit TIM14 0 9846000.0 2161700.0 6253700.0 1430600.0 False True 3279456.941438807 5137678.37461889 1147841.2829457456 1.0 1.5666247389010752 0.35000956055917887 21.645025502229004 -6.780029466314003 1.5354502213992087 1.3208205553532153 0.340310550265704 0.7676004836633403 0.23962648119938126 0.25052571384090305 1.1665851476933482 0.12291050475007995 0.29004708758936626 1.6594743104508613e-07 6.780029466314003 -0.9805100050875113 down SAFSGGYYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAFSGGYYR 9 0 Q96DA6-2;Q96DA6;A0A2R8Y817;F2Z3A7 Q96DA6-2 DNAJC19 Mitochondrial import inner membrane translocase subunit TIM14 0 5896800.0 2285200.0 1704000.0 1907600.0 False True 3130100.195207956 1628711.645625536 1457064.1682552202 1.0 0.5203385016617108 0.46550080744569156 21.577777408212437 -13.999999999999998 0.30610075941072207 5.532346617068953 0.4528421256627981 0.999663393440248 0.004404816323001985 16.99693345247534 0.17590096471442335 48.95955732246313 0.01931229141527937 1.0000000000000041e-14 13.999999999999998 -5.079504491406155 SAFSGGYYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAFSGGYYR 9 0 Q96DA6-2;Q96DA6;A0A2R8Y817;F2Z3A7 Q96DA6-2 DNAJC19 Mitochondrial import inner membrane translocase subunit TIM14 0 6234700.0 2161700.0 2610100.0 1462900.0 False True 2798363.263477449 2464845.640537705 1196667.2106215763 1.0 0.8808168948997384 0.4276311178894305 21.416151824321453 -6.946039852215392 0.600755598564453 1.0050961223655535 0.28012324322933513 0.9988526699173461 0.008352012840019027 0.08511612320514927 0.042852572372626685 0.00856564538550446 0.03809392965652636 1.1322964554159639e-07 6.946039852215392 -0.7249728791362183 down SAGGLMFNTGIGQHILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAGGLMFNTGIGQHILK 17 0 Q9UNQ2;A0A494C0G7;A0A0C4DGB1;D6RCL3 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 0 36211000.0 10263000.0 10856000.0 15092000.0 False True 13454892.387033392 9236327.116356557 13530424.612686438 1.0 0.6864660712751366 1.005613736883235 23.681627516482017 -10.952732154711045 10.769366880248281 1.0476829817735538 0.8460399040791877 0.23681181893585967 0.13029148889003878 0.08171818175192724 0.00035866894765662855 0.06911128394949874 0.04205139721864073 1.1149819717422089e-11 10.952732154711045 -0.20164307769436607 SAGGLMFNTGIGQHILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAGGLMFNTGIGQHILK 17 0 Q9UNQ2;A0A494C0G7;A0A0C4DGB1;D6RCL3 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 0 28467400.0 11536000.0 5774400.0 11157000.0 False True 11169795.994487157 8080148.033098192 8234646.997174499 1.0 0.7233926239195543 0.7372244758309553 23.413099500844815 -10.096497991969443 7.477772334403744 1.0000000472807988 0.7303085498782553 0.998031061823833 0.0056468298967788265 4.450259790425131e-09 5.338686901767414e-10 0.005467520514937769 0.001822506512424207 8.007593309380123e-11 10.096497991969443 -0.2696914974025435 SAGGLMFNTGIGQHILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAGGLMFNTGIGQHILK 17 0 Q9UNQ2;A0A494C0G7;A0A0C4DGB1;D6RCL3 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 0 33753300.0 5941300.0 15764000.0 12048000.0 False True 9013386.467211178 12950791.035305845 9666707.51917402 1.0 1.4368396476083796 1.0724834172305258 23.10363781981715 -10.222479590033952 6.016436964002869 0.9999946536078201 1.2546615324194539 0.3944340941786171 0.1487478081716207 1.0667618861964781e-05 1.3783905801881586e-06 0.14402746697513744 0.04800814865279457 5.991290944310872e-11 10.222479590033952 0.25466687881163375 SAGGLMFNTGIGQHILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAGGLMFNTGIGQHILK 17 0 Q9UNQ2;A0A494C0G7;A0A0C4DGB1;D6RCL3 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 0 10263000.0 10263000.0 0.0 0.0 False True 14057508.44714654 0.0 0.0 1.0 0.0 0.0 23.74483757800491 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 SAGGLMFNTGIGQHILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAGGLMFNTGIGQHILK 17 0 Q9UNQ2;A0A494C0G7;A0A0C4DGB1;D6RCL3 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 0 16471300.0 11536000.0 4935300.0 0.0 False True 9592695.131451612 4908712.5593196545 0.0 1.0 0.5117135999897919 0.0 23.19350477627909 -7.892914681368034 0.6002287248954604 1.0087849742226307 3.324284847406139e-18 0.9887231800544609 0.04335681949576201 0.11342875059768792 0.15997551857189207 0.0443461365670016 0.0773208338570345 1.27963266766737e-08 7.892914681368034 -1.0087849742226307 down SAGLAFSLYQAMAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAGLAFSLYQAMAK 14 0 P50454;E9PPV6;E9PR70;E9PK86;E9PMI5;E9PNX1;E9PJH8;E9PIG2;E9PRS3;E9PLA6 P50454 SERPINH1 Serpin H1 0 12114800.0 2293100.0 5911500.0 3910200.0 False True 3006276.306411988 5029527.24284652 3505610.013286939 1.0 1.6730089752958521 1.166097076908712 21.519546182560806 -10.467681593580396 5.310105435023249 0.9993746587751451 1.4195530261021312 0.4773623563931 0.2069459159323549 0.0015342744127372957 0.0001538048431484998 0.20066135563749649 0.06679150716430225 3.406578541566421e-11 10.467681593580396 0.4201783673269861 SAGLAFSLYQAMAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAGLAFSLYQAMAK 14 0 P50454;E9PPV6;E9PR70;E9PK86;E9PMI5;E9PNX1;E9PJH8;E9PIG2;E9PRS3;E9PLA6 P50454 SERPINH1 Serpin H1 0 22605500.0 9234500.0 5758400.0 7612600.0 False True 8941355.852209732 8057759.149659288 5618631.686895285 1.0 0.9011786671780796 0.628386989598084 23.092062185178317 -6.953305044217441 0.5212988700850989 1.004589353388913 0.5127755058038471 0.9994357759119104 0.003732944057042798 0.08218513219315486 0.03067532738654233 0.0042202579755702485 0.02253567633509364 1.113512138761315e-07 6.953305044217441 -0.49181384758506586 SAGLAFSLYQAMAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAGLAFSLYQAMAK 14 0 P50454;E9PPV6;E9PR70;E9PK86;E9PMI5;E9PNX1;E9PJH8;E9PIG2;E9PRS3;E9PLA6 P50454 SERPINH1 Serpin H1 0 55715600.0 9728600.0 19024000.0 26963000.0 False True 14758997.455928953 15629018.564809583 21633751.231697276 1.0 1.0589485235347829 1.4658008646113434 23.815091390048696 -6.932948719260513 0.7221728071354453 0.9944391542526634 1.5559656362564251 0.9970868203075777 0.011177417242984425 0.09113513424413568 0.07038821480136305 0.01036807940780534 0.03623465032784605 1.166947400052076e-07 6.932948719260513 0.5615264820037618 SAGLAFSLYQAMAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAGLAFSLYQAMAK 14 0 P50454;E9PPV6;E9PR70;E9PK86;E9PMI5;E9PNX1;E9PJH8;E9PIG2;E9PRS3;E9PLA6 P50454 SERPINH1 Serpin H1 0 15053600.0 2293100.0 4424200.0 8336300.0 False True 3140921.038697427 4228724.215127059 6367437.631487735 1.0 1.3463325448260093 2.0272517370027163 21.582756244083697 -6.960377934860786 0.4300737911237616 0.9729740103252117 2.4267256132804693 0.9997839615017908 0.006272098243218886 0.07956638529694222 0.02063447019982787 0.008879646432334267 0.056536400275759575 1.0955244260768918e-07 6.960377934860786 1.4537516029552577 up SAGLAFSLYQAMAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAGLAFSLYQAMAK 14 0 P50454;E9PPV6;E9PR70;E9PK86;E9PMI5;E9PNX1;E9PJH8;E9PIG2;E9PRS3;E9PLA6 P50454 SERPINH1 Serpin H1 0 16872000.0 9234500.0 3421000.0 4216500.0 False True 7678895.90771409 3402570.393984666 5098150.655106735 1.0 0.4431067219659145 0.6639171459513104 22.872467460612594 -10.225592887660985 5.505323666609352 1.0000243471455592 0.5535119339585862 0.8449982783928145 0.09014547810874052 2.694018941987432e-05 3.7894651138209556e-06 0.08728773515244118 0.029094327954240006 5.948495157006525e-11 10.225592887660985 -0.446512413186973 SAGLAFSLYQAMAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAGLAFSLYQAMAK 14 0 P50454;E9PPV6;E9PR70;E9PK86;E9PMI5;E9PNX1;E9PJH8;E9PIG2;E9PRS3;E9PLA6 P50454 SERPINH1 Serpin H1 0 48665600.0 9728600.0 18224000.0 20713000.0 False True 12593864.479375836 17209818.379816502 16943446.53332744 1.0 1.3665240250917357 1.3453731029958784 23.586217712141146 -10.219669695568575 5.039473198734677 0.9999584167351777 1.3559485640440652 0.9973588259983888 0.008634827788315204 4.034836598944866e-06 6.247584633845647e-07 0.00836161078933068 0.0027868786849904637 6.030180395311279e-11 10.219669695568575 0.35599014730888745 SAGVEQLMYIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAGVEQLMYIK 11 0 Q14320;B0S8I6 Q14320 FAM50A Protein FAM50A 0 3183700.0 0.0 1432100.0 1751600.0 False True 0.0 1218436.2622820772 1570361.2345336305 0.0 SAGVQCFGPTAEAAQLESSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAGVQCFGPTAEAAQLESSK 20 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 9222100.0 0.0 4359600.0 4862500.0 False True 0.0 3709164.673587703 4359375.144393573 0.0 SAGVQCFGPTAEAAQLESSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAGVQCFGPTAEAAQLESSK 20 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 10113900.0 0.0 3752000.0 6361900.0 False True 0.0 3586224.233795199 4859350.247443326 0.0 SAGVQCFGPTAEAAQLESSK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAGVQCFGPTAEAAQLESSKR 21 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 38690800.0 7238800.0 13205000.0 18247000.0 True False 9490136.90063892 11234865.472686838 16358975.477583453 1.0 1.183846512470274 1.7237870906248036 23.177997468419694 -6.9519275792872675 0.5372662506085993 0.9919045688696657 1.9405469777850837 0.9993439947753396 0.007867523852556102 0.08272085328308251 0.03282967281411708 0.008686240932300436 0.044695736517304616 1.117049505677166e-07 6.9519275792872675 0.948642408915418 SAGVQCFGPTAEAAQLESSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAGVQCFGPTAEAAQLESSKR 21 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 31788800.0 9386000.0 13149000.0 9253800.0 True False 9088046.567636644 18399464.271129135 6829952.17195065 1.0 2.0245785641824603 0.7515313792815199 23.115538796632254 -6.692458279234562 1.8574629628052768 1.640845353053527 0.755767224640378 0.38208067725043726 0.4331084594735789 0.4113916785045465 2.753727475824392 0.18639417421649015 0.48392366983955043 2.0302135441997309e-07 6.692458279234562 -0.8850781284131489 SAGVQCFGPTAEAAQLESSK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAGVQCFGPTAEAAQLESSKR 21 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 179599000.0 24816000.0 28603000.0 126180000.0 True False 37647686.29261485 23498571.173740998 101240467.6933413 1.0 0.6241703936624279 2.6891551025594134 25.166057868371976 -6.859771727165407 1.1868858815825147 0.7962127794931273 2.788717507583446 0.9533620031457267 0.1939441829347087 0.14703820137110207 0.39372021764518056 0.12746024098295425 0.29745468814654813 1.3811100096185855e-07 6.859771727165407 1.9925047280903188 up SAGVQCFGPTAEAAQLESSK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAGVQCFGPTAEAAQLESSKR 21 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 39198800.0 7238800.0 14607000.0 17353000.0 True False 9915179.981214488 13961614.441110441 13254578.796253324 1.0 1.4081049933094927 1.3367965908199078 23.241207529942585 -10.056050282275434 4.3366109037249965 0.9999713590821626 1.3724507920760207 0.9732436735752612 0.029111533607484988 4209999.770148411 3254151.9732046975 1049.9543630507587 0.009965652869349528 8.789207501827527e-11 10.056050282275434 0.3724794329938581 SAGVQCFGPTAEAAQLESSK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAGVQCFGPTAEAAQLESSKR 21 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 37512000.0 9386000.0 7358000.0 20768000.0 True False 7804874.870302075 7318360.993551345 25110492.779617365 1.0 0.937665384156005 3.2172831976030776 22.89594407206653 -6.900613390566931 0.9573779788931026 0.90681000158651 3.4595740004908273 0.9868690856583533 0.12149256321981197 0.11095542730009862 0.17488282242154274 0.09506544008655023 0.2481150521311471 1.2571485807952641e-07 6.900613390566931 2.552763998904317 up SAGVQCFGPTAEAAQLESSK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAGVQCFGPTAEAAQLESSKR 21 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 145688000.0 24816000.0 23847000.0 97025000.0 True False 32124801.196491856 22519893.486802243 79367445.5605704 1.0 0.7010126957380672 2.4705972521080573 24.937184190464425 -6.8634342333803 1.1683596866693604 0.8360709585012327 2.562042830461979 0.9576741454986825 0.15911573584506936 0.14330029882178108 0.36978833674858996 0.10606703167921697 0.24861286017433643 1.3695117622899927e-07 6.8634342333803 1.7259718719607464 up SAHAGTYEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAHAGTYEVR 10 0 P51571;A6NLM8 P51571 SSR4 Translocon-associated protein subunit delta 0 2981690.0 592310.0 1826700.0 562680.0 False True 898577.573661294 1500711.1129277581 451466.051368595 1.0 1.6700963354928218 0.5024230123272236 19.777283530543237 -6.751064204853058 1.6458044263870544 1.393518533471859 0.49989892011799514 0.6535726775833948 0.2815957612652095 0.2981957498725773 1.5894813884670587 0.1351397019706474 0.32773002075372876 1.7739272091830695e-07 6.751064204853058 -0.8936196133538639 SAHATAPVNIAGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAHATAPVNIAGSR 14 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 2511900.0 2511900.0 0.0 0.0 False True 3810735.9444882 0.0 0.0 1.0 0.0 0.0 21.8616382129569 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 SAHSLQPSISQK(ub)SVFQMFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAHSLQPSISQKSVFQMFQR 20 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 5736300.0 1616800.0 2124400.0 1995100.0 True False 1565475.5689915747 2972683.998599649 1472523.4582829492 1.0 1.8989015590416076 0.9406237231996524 20.578169563096363 -6.6605522894809255 1.970655820319848 1.5783351558648089 0.9445909557878033 0.23809026396706345 0.38267864137455093 0.48312092785334043 3.6072020413323482 0.1568465960048235 0.4243182073144304 2.184981229935629e-07 6.6605522894809255 -0.6337442000770056 SAIDISILQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAIDISILQR 10 0 Q92556 Q92556 ELMO1 Engulfment and cell motility protein 1 0 7613600.0 1668700.0 3034200.0 2910700.0 False True 1615728.0319001987 4245771.88314397 2148300.350871725 1.0 2.6277763332178328 1.3296175522468268 20.62375294560096 -6.589607293559526 2.2295346161855996 2.101930139346551 1.3332870845133487 0.0 0.7054266924460799 0.6707170994800278 6.284407191871028 0.2641387469451596 0.7867130116072212 2.572721088599398e-07 6.589607293559526 -0.7686430548332024 SAIDISILQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAIDISILQR 10 0 Q92556 Q92556 ELMO1 Engulfment and cell motility protein 1 0 4028200.0 0.0 0.0 4028200.0 False True 0.0 0.0 3076822.123383142 0.0 SAIDISILQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAIDISILQR 10 0 Q92556 Q92556 ELMO1 Engulfment and cell motility protein 1 0 1668700.0 1668700.0 0.0 0.0 False True 1387597.9859442858 0.0 0.0 1.0 0.0 0.0 20.404158221035235 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 SAIDLEEMASGLNK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAIDLEEMASGLNKR 15 1 P61011-2;P61011;G3V480 P61011-2 SRP54 Signal recognition particle 54 kDa protein 1 6073200.0 2532400.0 1747500.0 1793300.0 True False 3320000.923796486 1486779.8117016475 1607746.5185482737 1.0 0.44782511988023355 0.48426086481620134 21.662752212329032 -10.114491195069547 7.5549735731974 1.0000001090211157 0.46604299234821744 0.9965199135244689 0.014874830581886229 2.7318770482602704e-08 3.1957847874735827e-09 0.014402495677560505 0.004800830926775173 7.682610313235836e-11 10.114491195069547 -0.5339571166728982 SAIDLEEMASGLNK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAIDLEEMASGLNKR 15 1 P61011-2;P61011;G3V480 P61011-2 SRP54 Signal recognition particle 54 kDa protein 1 9474000.0 3378600.0 3577900.0 2517500.0 True False 3271348.192352139 5006574.1285020085 1858091.2266188762 1.0 1.530431441142993 0.5679894396331092 21.641453892989816 -6.757087942059936 1.6233626668148111 1.309224033785422 0.5649667272408874 0.6789494008159458 0.2230187119478031 0.2878613834922039 1.4944276602919095 0.10842810997145398 0.2613317667531619 1.7494923909086592e-07 6.757087942059936 -0.7442573065445346 SAIDLEEMASGLNK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAIDLEEMASGLNKR 15 1 P61011-2;P61011;G3V480 P61011-2 SRP54 Signal recognition particle 54 kDa protein 1 10236200.0 3378600.0 4795200.0 2062400.0 True False 2809455.5973580433 4769367.305827327 2493638.3045398183 1.0 1.6976126301167906 0.887587725851509 21.421859168424092 -6.6788185591844105 1.9059734308552363 1.4418576344183747 0.8906943847134232 0.31872626750568567 0.2957422093244474 0.44118295897359533 3.097602615200289 0.12455017335829688 0.32900418270917214 2.0949875230430547e-07 6.6788185591844105 -0.5511632497049515 SAIELDTPSMTAEQVAAIEQSVNEK(ub)IR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAIELDTPSMTAEQVAAIEQSVNEKIR 27 1 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3;L7N2F4;K7N799 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 1 71351300.0 5496300.0 11385000.0 54470000.0 True False 8338288.933353442 9353257.79858899 43703980.62495083 1.0 1.1217238780459666 5.2413607844810235 22.991319933734086 -6.9132125958504025 0.8735688745383197 0.8850397321286421 5.812033007654854 0.9920785664103106 0.17545339384541506 0.10233180873308571 0.1275263692672775 0.1459679263204282 0.41249843627536087 1.221201711117241e-07 6.9132125958504025 4.926993275526212 up SAIILHLSNGSVQINFFQDHTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAIILHLSNGSVQINFFQDHTK 22 0 P53350 P53350 PLK1 Serine/threonine-protein kinase PLK1 0 78282400.0 12520400.0 30399000.0 35363000.0 False True 18994362.1638481 24974060.94152891 28373487.549846463 1.0 1.314814402615843 1.4937846980642298 24.179067930912897 -10.99518110741148 0.09332438333369476 4.138129506202701e-18 2.001688938372796 0.9999133610069324 0.0018998834191865802 3.35918301470334 0.0572246514418023 1.0496426262217886 0.32877597116166274 1.0111576981707287e-11 10.99518110741148 2.001688938372796 SAIILHLSNGSVQINFFQDHTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAIILHLSNGSVQINFFQDHTK 22 0 P53350 P53350 PLK1 Serine/threonine-protein kinase PLK1 0 25562000.0 12520400.0 8562000.0 4479600.0 False True 16207904.613981148 8085517.173397108 3664358.764577492 1.0 0.4988625837804127 0.22608466990955567 23.950194253005346 -8.956392830879567 0.2266253956412087 1.3434884122845234 8.842764027082938e-14 0.9993942709496874 0.00788804313976949 0.4331332095481373 0.07386505369461824 0.23796958824788586 0.12406393269937918 1.1056232659750056e-09 8.956392830879567 -1.343488412284435 SAINEVVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAINEVVTR 9 0 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2;B8ZZK4 H7C2W9 RPL31 60S ribosomal protein L31 0 18596300.0 1948700.0 9418000.0 7229600.0 False True 2554764.571237643 8012871.111076458 6481550.343220103 1.0 3.136442082095519 2.5370440846845423 21.284758918194548 -9.980080476381236 5.156594019430847 0.9999906250915167 2.8367430833982614 0.9260356067722059 0.2447032077970472 2.844031403518065e-05 5.625325850357142e-06 0.23693416489317545 0.0789776207067636 1.0469345292168156e-10 9.980080476381236 1.8367524583067447 SAINEVVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAINEVVTR 9 0 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2;B8ZZK4 H7C2W9 RPL31 60S ribosomal protein L31 0 18244100.0 5040600.0 2424500.0 10779000.0 False True 4880588.912084942 3392615.4936004723 7955656.5369314365 1.0 0.6951242062612437 1.6300607734513854 22.21862380917853 -6.818884185990068 1.376710914621767 0.8354873516269636 1.6499848381092486 0.8817973065050256 0.13384579903304528 0.19493341119680174 0.7262792851898564 0.07640546046254337 0.17615549619405282 1.5174549756739337e-07 6.818884185990068 0.8144974864822849 SAINEVVTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAINEVVTR 9 0 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2;B8ZZK4 H7C2W9 RPL31 60S ribosomal protein L31 0 65827700.0 4011600.0 59003700.0 2812400.0 False True 6085890.487244255 48474028.73698778 2256527.9072812884 1.0 7.964985377010497 0.37078023536750565 22.53703694278708 -6.665431630965153 1.953196723772119 5.462761943102587 0.4015508510128197 0.25930185923813476 2.961658433170713 0.4715633641445105 3.463639862701594 1.222550812381702 3.28637489991287 2.1605701368819567e-07 6.665431630965153 -5.061211092089767 SAINEVVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAINEVVTR 9 0 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2;B8ZZK4 H7C2W9 RPL31 60S ribosomal protein L31 0 17000500.0 1948700.0 7164900.0 7886900.0 False True 2669187.051637379 6848331.026844139 6024176.655804201 1.0 2.5656991789478063 2.256933118309841 21.34796897971744 -10.521124805863566 5.217855868671812 0.9955236655655221 2.411316148628827 0.9653458931810756 0.1260532164087512 0.006565698875229714 0.0006025746222799678 0.12208159886759758 0.04068350065724193 3.012140282605129e-11 10.521124805863566 1.4157924830633046 SAINEVVTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAINEVVTR 9 0 H7C2W9;C9JU56;B7Z4E3;B7Z4C8;P62899-3;P62899;P62899-2;B8ZZK4 H7C2W9 RPL31 60S ribosomal protein L31 0 9093100.0 4011600.0 2242700.0 2838800.0 False True 5193095.28045803 2117891.77350826 2322167.5285477648 1.0 0.40782840659173547 0.447164437226145 22.30816326487953 -10.196810568741704 6.008203713077965 1.0000085516948292 0.4274964219089361 0.996471817866208 0.01605886726014662 1.839589856200989e-06 2.459265427550809e-07 0.015549163536744058 0.005182977121456452 6.356081119547628e-11 10.196810568741704 -0.572512129785893 SAITTTINPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAITTTINPR 10 0 P26010;P26010-2 P26010 ITGB7 Integrin beta-7 0 10092200.0 2818100.0 3169900.0 4104200.0 False True 3694556.39051922 2696963.276173426 3679536.7542663384 1.0 0.7299829779548728 0.9959346577328135 21.816969718101873 -10.823347557008477 9.478145369077799 1.0029007711754359 0.8629588178680687 0.2614618753581911 0.10857431861533705 0.006769172835573068 0.0001261627861748596 0.10692573871422802 0.03504221065191819 1.5019395134719898e-11 10.823347557008477 -0.13994195330736714 SAK(ub)EQVALQEGHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAKEQVALQEGHK 13 1 Q8N370-4;Q8N370;Q8N370-3;Q8N370-2 Q8N370-4 SLC43A2 Large neutral amino acids transporter small subunit 4 1 7019000.0 2181000.0 2470000.0 2368000.0 True False 2859312.120834047 2101485.62798459 2122982.075459944 1.0 0.7349619555949691 0.7424800041908964 21.44723668163371 -10.495553191419196 6.112899886220573 1.0002155121203757 0.7387209798929327 0.9993794248454622 0.003069230486911614 9.022029186117262e-06 7.445139752989262e-07 0.0029741933719883004 0.0009905898801233852 3.194823046046023e-11 10.495553191419196 -0.261494532227443 SAK(ub)EQVALQEGHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAKEQVALQEGHK 13 1 Q8N370-4;Q8N370;Q8N370-3;Q8N370-2 Q8N370-4 SLC43A2 Large neutral amino acids transporter small subunit 4 1 4654500.0 1451600.0 1334400.0 1868500.0 True False 1405519.752565667 1867232.8788040734 1379083.7962015371 1.0 1.3284999199730811 0.9811913305978994 20.422672298195963 -6.658696045889524 1.9770580720899174 1.2116684914406426 0.982627110657133 0.23031714970162376 0.13990953703024744 0.4875063013197739 3.6615986990977505 0.05719483186841611 0.1551203314845937 2.1943401732940102e-07 6.658696045889524 -0.22904138078350955 SAK(ub)EQVALQEGHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAKEQVALQEGHK 13 1 Q8N370-4;Q8N370;Q8N370-3;Q8N370-2 Q8N370-4 SLC43A2 Large neutral amino acids transporter small subunit 4 1 5548600.0 2181000.0 1094100.0 2273500.0 True False 2987374.6393088377 1045759.04429513 1736546.1242022647 1.0 0.3500595574906125 0.5812950613398907 21.510446743156603 -10.178379584970067 5.3546749009654775 1.0000212957727084 0.4656773094151683 0.8768365843243586 0.09440149914149015 2.4000627062323074e-05 3.6829403650512422e-06 0.09140749418444552 0.030467952835932177 6.631631946910256e-11 10.178379584970067 -0.5343439863575401 SAK(ub)EQVALQEGHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAKEQVALQEGHK 13 1 Q8N370-4;Q8N370;Q8N370-3;Q8N370-2 Q8N370-4 SLC43A2 Large neutral amino acids transporter small subunit 4 1 5154300.0 1451600.0 2033700.0 1669000.0 True False 1207069.7167835594 2022744.0544421582 2017980.1834159005 1.0 1.6757474952085623 1.671800854049382 20.20307757363024 -10.070114886832881 5.13908987134529 0.9999887862629123 1.6737741746307875 0.9999742674854055 0.0016112095126328786 2.0701159061343865e-07 3.7460088673487094e-08 0.00156007286138099 0.0005200156332313517 8.509129107255923e-11 10.070114886832881 0.6737853883678752 SAK(ub)IVDGPDPENIILILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAKIVDGPDPENIILILK 18 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 13544800.0 4178400.0 3044500.0 6321900.0 True False 4045758.9791405196 4260184.726857756 4666004.737065291 1.0 1.0530001289801967 1.1533076392149628 21.947978945088884 -6.9611099934939284 0.4194980916978126 0.9955421998607964 1.214546301661482 0.999809166691076 0.0008781951683999114 0.07930695855922601 0.019683754234828574 0.0012971547450289947 0.008350995712996126 1.0936793357052279e-07 6.9611099934939284 0.21900410180068552 SAK(ub)IVDGPDPENIILILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAKIVDGPDPENIILILK 18 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 11954400.0 4178400.0 4049700.0 3726300.0 True False 3474524.734505663 4027883.462297485 4505452.101535448 1.0 1.1592617034198638 1.2967103261034807 21.72838422052316 -6.972844283118539 0.17755602847860183 0.8902404977484157 1.5694394027278646 0.9999969105466026 0.00021302435772399908 0.07539013079330409 0.005584240870239258 0.005409213482614163 0.01554113841027641 1.0645246365721578e-07 6.972844283118539 0.6791989049794489 SAK(ub)LIQQQLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAKLIQQQLEK 11 1 Q9Y5M8;H7C4H2 Q9Y5M8 SRPRB Signal recognition particle receptor subunit beta 1 19123700.0 6655800.0 8359100.0 4108800.0 True False 8725818.254858883 7111954.863516589 3683660.790392657 1.0 0.8150473291781397 0.42215648811404566 23.056858994271177 -6.958848740859705 0.4513656402482975 1.012494546831853 0.20909830333811721 0.9997250898376491 0.003994900428044635 0.08011495588686267 0.02267035584397236 0.005262178753992797 0.032492082511799164 1.0993886755896294e-07 6.958848740859705 -0.8033962434937357 down SAK(ub)LIQQQLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAKLIQQQLEK 11 1 Q9Y5M8;H7C4H2 Q9Y5M8 SRPRB Signal recognition particle receptor subunit beta 1 25309100.0 7514900.0 12224300.0 5569900.0 True False 7276343.612948291 17105526.738882337 4110976.0965817263 1.0 2.350840978488559 0.5649782796494414 22.79478224274119 -6.704396079872012 1.8151314105898069 1.8351718466940057 0.569817317850333 0.4385042187092457 0.569760445963281 0.386440193087978 2.4782045986371193 0.25013217354847606 0.6398207434502222 1.9751674506876042e-07 6.704396079872012 -1.2653545288436727 SAK(ub)LIQQQLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAKLIQQQLEK 11 1 Q9Y5M8;H7C4H2 Q9Y5M8 SRPRB Signal recognition particle receptor subunit beta 1 15409000.0 6655800.0 5383700.0 3369500.0 True False 9116629.12623188 5145830.332484867 2573693.4970308077 1.0 0.5644444082603326 0.2823075789740474 23.12006905579407 -8.380624870821286 0.22087633750382787 1.2632211908298718 1.3689517367552344e-22 0.9996247920229265 0.005718487940176343 0.11585984344224529 0.05276095323835402 0.12398835947218871 0.11561262757522137 4.162700154926655e-09 8.380624870821286 -1.2632211908298718 down SALALAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SALALAIK 8 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 114846000.0 30607000.0 33430000.0 50809000.0 False True 40126073.398609646 28442374.30911936 45551772.07434297 1.0 0.7088252574971584 1.1352162874706133 25.258036649995088 -6.722865747386185 1.7489095027792312 0.8233961566106138 1.1346647463849349 0.5260149244740584 0.12248661076827956 0.34979604511015283 2.0924395982379282 0.05557561997521443 0.1390524915631933 1.8929286855960608e-07 6.722865747386185 0.31126858977432104 SALALAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SALALAIK 8 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 57789400.0 23487000.0 9672400.0 24630000.0 False True 22741418.0411338 13534639.76089967 18178664.11583831 1.0 0.5951537294824244 0.7993637020768646 24.438818880496544 -10.267114345150326 4.7319192041278 1.0001030661240882 0.6972587157789705 0.745573508000775 0.08336837220966639 9.067830932195729e-05 1.4044242564439707e-05 0.08074845607806132 0.026907026430376922 5.406119667847335e-11 10.267114345150326 -0.3028443503451177 SALALAIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SALALAIK 8 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 101517000.0 27410000.0 44758000.0 29349000.0 False True 41582973.93941696 36770585.204149865 23548157.28587634 1.0 0.884270212556746 0.5662932458891494 25.30948960504902 -6.95340822214052 0.520084446773228 1.005399736720459 0.4309714868811383 0.9994423107400637 0.0043302406802300745 0.08214538395081157 0.03051689400165789 0.0049049491153438625 0.026265278284530322 1.1132476264818976e-07 6.95340822214052 -0.5744282498393207 SALALAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SALALAIK 8 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 84961000.0 30607000.0 21704000.0 32650000.0 False True 41923235.02307454 20745045.51446987 24938742.447857473 1.0 0.49483408193694506 0.5948668425547599 25.32124671151798 -9.962734355413613 5.812852606632676 1.0000004252866983 0.5448504622457127 0.9650391097717026 0.040838203513328154 2.2509374300300918e-07 4.019083865126202e-08 0.03954145734823575 0.013180473507906694 1.0895963621501839e-10 9.962734355413613 -0.45514996304098565 SALALAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SALALAIK 8 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 47433500.0 23487000.0 15125000.0 8821500.0 False True 19530481.150520433 15043518.622922579 10666034.863992428 1.0 0.7702584747904028 0.5461224831989461 24.21922415593082 -6.971428562864089 0.2214368033782847 1.1015045581964826 0.20853691753485104 0.9999914800618921 0.0005408384521095001 0.07584193462112057 0.007349550941552244 0.006140665236439683 0.022648700064296434 1.0680004535760244e-07 6.971428562864089 -0.8929676406616316 SALALAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SALALAIK 8 0 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 0 89512000.0 27410000.0 39277000.0 22825000.0 False True 35482785.33187622 37091200.42274215 18671084.204277415 1.0 1.0453294485148832 0.5262011995293986 25.08061592714147 -6.885629726252906 1.0478665551438973 1.0308850095979312 0.485191079115262 0.9779513350954356 0.03485986483753066 0.12276165630465041 0.24312316431692052 0.025481882805203547 0.0626065224295413 1.301278558150521e-07 6.885629726252906 -0.5456939304826691 SALASVIMGLSPILGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SALASVIMGLSPILGK 16 0 P30153;B3KQV6 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0 313478000.0 104720000.0 74898000.0 133860000.0 False True 101395720.92083001 104805161.98791029 98798050.28607874 1.0 1.0336250981413937 0.9743808652755718 26.595421528436596 -6.752729717488553 1.639487863732657 1.019707301809014 0.9742365832951557 0.6606641966773006 0.014131981941974873 0.2953443195693372 1.562678515361182 0.006806498381084764 0.01647890692126486 1.7671372537223428e-07 6.752729717488553 -0.0454707185138582 SALASVIMGLSPILGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SALASVIMGLSPILGK 16 0 P30153;B3KQV6 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0 66160000.0 38915000.0 14835000.0 12410000.0 False True 59036900.06758169 12187578.343615964 9957158.06050377 1.0 0.2064400117496752 0.16865990675502013 25.81511363400855 -13.34754718237239 0.440591778801214 9.999999999992173 0.16831918842452648 0.9998784765695583 0.004225439564844947 18.500540013053477 0.22380437311689705 158.1514217062198 0.008718968746111395 4.492135188213182e-14 13.34754718237239 -9.831680811567647 SALASVIMGLSPILGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SALASVIMGLSPILGK 16 0 P30153;B3KQV6 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0 193116000.0 104720000.0 0.0 88396000.0 False True 87079319.88259473 0.0 106879194.90307474 1.0 0.0 1.2273774651338034 26.375826803870872 -6.690036369162881 1.8660430115857858 0.373098657471527 1.2231674909200745 0.3707245075230259 0.4229243230707659 0.41657989014025876 2.812387526602163 0.1812990874807287 0.4721361738368147 2.0415669703794465e-07 6.690036369162881 0.8500688334485476 SALASVIMGLSPILGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SALASVIMGLSPILGK 16 0 P30153;B3KQV6 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 0 76874300.0 38915000.0 20996600.0 16962700.0 False True 50376234.62933111 19828120.75250523 13875662.651999863 1.0 0.39360069084957944 0.27544064684661607 25.586239956101 -13.999999999999998 0.22994822559930775 4.827102548441322 0.21796191550985916 0.9995097232112966 0.007027865655937412 13.289667290664 0.1518340576628827 23.220883797231647 0.06135541120325269 1.0000000000000041e-14 13.999999999999998 -4.609140632931463 SALASVIMGLSTILGK ddPTM_RPMI8226_Bortezomib_8h_R1 2 SALASVIMGLSTILGK 16 0 P30154;P30154-2;P30154-3;P30154-5;H0YDG7 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 0 1566580000.0 647450000.0 509290000.0 409840000.0 False True 982228984.9352633 418403220.39906824 328834944.3607463 1.0 0.4259731964910854 0.33478440303043916 29.871484155247852 -13.999999999999998 0.25894419073119784 5.179120253161705 0.3011169052579216 0.9995601868106693 0.0061752270924462635 14.370655548905148 0.16102652464852688 31.40621037845279 0.040089322103997425 1.0000000000000041e-14 13.999999999999998 -4.878003347903784 SALASVIMGLSTILGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SALASVIMGLSTILGK 16 0 P30154;P30154-2;P30154-3;P30154-5;H0YDG7 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 0 608189000.0 385270000.0 83869000.0 139050000.0 False True 498739609.8070769 79201616.42322382 113744326.77348423 1.0 0.15880354169956684 0.22806355167475661 28.89371154522397 -10.69385902233769 10.001301014316232 1.000699571461533 0.19343354668718968 0.9945001490014969 0.028275280669881324 0.00044132786513769953 1.3509067403914509e-05 0.027394053080144205 0.009125807595315904 2.0236759837297257e-11 10.69385902233769 -0.8072660247743433 SALGITVHQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SALGITVHQGR 11 0 Q14145 Q14145 KEAP1 Kelch-like ECH-associated protein 1 0 9261300.0 4223500.0 3432700.0 1605100.0 False True 5537049.400432175 2920554.5405598017 1439019.6492063992 1.0 0.527456832935579 0.25988925601676616 22.400685962682566 -8.8983129723059 0.21021530926117662 1.360872440461648 2.0762601499467885e-19 0.9995388163532131 0.0065711292162821495 0.39109654284040996 0.06619981700130122 0.2292913549793882 0.13138993709346639 1.2638252494117525e-09 8.8983129723059 -1.360872440461648 down SALGITVHQGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SALGITVHQGR 11 0 Q14145 Q14145 KEAP1 Kelch-like ECH-associated protein 1 0 3673540.0 1183600.0 742240.0 1747700.0 False True 1146027.265869885 1038620.3027304658 1289924.940123859 1.0 0.9062788763076308 1.125562173378789 20.12820993791055 -6.790596478128229 1.4941760779348492 0.9476589808091893 1.1279250855136247 0.803165865576408 0.03985666360801451 0.23447410326490942 1.0341711747913855 0.02099627875201236 0.04913134102411361 1.6195841647728973e-07 6.790596478128229 0.18026610470443538 SALGITVHQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SALGITVHQGR 11 0 Q14145 Q14145 KEAP1 Kelch-like ECH-associated protein 1 0 6460460.0 4223500.0 1379900.0 857060.0 False True 5785042.085795897 1318931.455280916 654640.0797047692 1.0 0.2279899498949729 0.113160815426411 22.463896024205457 -13.999999999999998 0.2683278986648748 6.905520244241952 0.0744229164136093 0.9995797458647532 0.008072830725468275 14.80169259376977 0.16396512243818503 47.63544447311767 0.048092742228149 1.0000000000000041e-14 13.999999999999998 -6.831097327828343 SALGITVHQGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SALGITVHQGR 11 0 Q14145 Q14145 KEAP1 Kelch-like ECH-associated protein 1 0 9443000.0 2471800.0 5690000.0 1281200.0 False True 3199793.8264623033 5373346.498088016 1048034.7462221346 1.0 1.6792789753047295 0.32753196082662717 21.609547519710905 -6.770062912902803 1.5740478869838046 1.3895808510448493 0.31988063822752894 0.7308668896829005 0.2862893527236766 0.26632445948803 1.3022224678677632 0.1433578474802481 0.341254420040747 1.6979976587776883e-07 6.770062912902803 -1.0697002128173203 SALLALGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SALLALGLK 9 0 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 0 81351000.0 28227000.0 25340000.0 27784000.0 False True 37005870.3506568 21559370.774546385 24909178.20294721 1.0 0.5825932634540438 0.6731142374686807 25.14125081208837 -9.984443289739886 5.931952347534677 1.0000003519489193 0.6278537504612982 0.9575110300128584 0.03695503289285631 1.72060766467285e-07 2.9392076595643707e-08 0.035781590861154414 0.011927185579344054 1.0364699380462508e-10 9.984443289739886 -0.37214660148762113 SALLALGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SALLALGLK 9 0 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 0 78765000.0 31374000.0 17757000.0 29634000.0 False True 30378049.543259334 24847462.70153172 21871966.39905614 1.0 0.8179413449882001 0.7199924527053571 24.85652590717199 -13.999999999948184 0.07634485753313267 2.004976543301403 0.4066360299297218 0.9999013206721636 0.0011524884036491765 12.295173404803824 0.07666356310940688 2.1239269562476837 0.2859393910664355 1.0000000001193116e-14 13.999999999948184 -1.5983405133716813 SALLALGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SALLALGLK 9 0 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 0 122172000.0 25478000.0 50069000.0 46625000.0 False True 38651988.6912976 41133795.7591175 37409548.31353652 1.0 1.0642090394789614 0.9678557192054438 25.204039308666005 -6.727046381867119 1.7336939289724285 1.0387660887805408 0.9679398680868079 0.5456795965765322 0.026998754248574584 0.341791266121378 2.011158682318979 0.012347197036564166 0.030745286509500508 1.874794272729374e-07 6.727046381867119 -0.0708262206937329 SALLALGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SALLALGLK 9 0 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 0 138337000.0 28227000.0 29566000.0 80544000.0 False True 38663284.70599284 28259676.358312566 61521166.05574988 1.0 0.7309176282669096 1.5912038132190576 25.20446087361126 -6.822648294509532 1.3603285441214112 0.8553402729336433 1.6110804435153716 0.8903738897778424 0.11897137263399224 0.19006399319829015 0.6903533507678928 0.06871266332543365 0.15827469963056284 1.5043597513174086e-07 6.822648294509532 0.7557401705817283 SALLALGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SALLALGLK 9 0 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 0 63278000.0 31374000.0 11396000.0 20508000.0 False True 26088871.10386291 11334607.486071121 24796127.981721576 1.0 0.4344614008381848 0.9504484836850636 24.636931182606265 -10.52101674766836 9.156131764397369 1.0000126553739055 0.6924549422616251 0.32142338499545253 0.21065084447367394 5.442146329603525e-05 2.846934004254508e-06 0.2039701802442094 0.06798726770925564 3.012889836081465e-11 10.52101674766836 -0.3075577131122804 SALLALGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SALLALGLK 9 0 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 0 115614000.0 25478000.0 55904000.0 34232000.0 False True 32981773.246462747 52792893.25643451 28002127.249981415 1.0 1.600668734877573 0.8490182453420574 24.975165630758454 -6.693907727928566 1.852938820896825 1.3751988942050775 0.8515149189297773 0.38863515926404346 0.2538430292863163 0.4082981977652248 2.7209642708828685 0.10948263833654169 0.283661272860084 2.0234490436881032e-07 6.693907727928566 -0.5236839752753002 SALLVQLATAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SALLVQLATAR 11 0 B0V3J0;A9C4B9;A0A0G2JNL0;A0A0G2JNK5;A0A590UJ73;A0A590UJW4;E7EQB3;Q9BSV6 B0V3J0 TSEN34 tRNA-splicing endonuclease subunit Sen34 0 3743600.0 1149300.0 1385300.0 1209000.0 False True 1506743.4298370339 1178618.6398571064 1083904.2775469047 1.0 0.7822291549561183 0.719368842818938 20.523002343250635 -13.999999999999998 0.17423382408032917 2.1109266398649917 0.6663462279006845 0.9995062377619398 0.002671925792756982 12.135540753963543 0.13225512415523583 4.558959901735621 0.04933910945827875 1.0000000000000041e-14 13.999999999999998 -1.4445804119643073 SALQHEK(ub)EGYTIYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SALQHEKEGYTIYK 14 1 I3L2B0;A0A494C0R8;K7EIG1;O75153 I3L2B0 CLUH Clustered mitochondria protein homolog 1 3656050.0 1210700.0 967950.0 1477400.0 True False 1658328.5079372802 925182.7684173943 1128468.5480081055 1.0 0.5579007802068042 0.6804855266051938 20.66129839631855 -10.35285639210519 8.603602221888693 1.0000010302403741 0.6191931534060041 0.9278860499965629 0.05004501315408873 9.889741543428627e-07 7.435707586864294e-08 0.04845600629740357 0.016151958542209733 4.437553559898487e-11 10.35285639210519 -0.38080787683437 SALQHEK(ub)EGYTIYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SALQHEKEGYTIYK 14 1 I3L2B0;A0A494C0R8;K7EIG1;O75153 I3L2B0 CLUH Clustered mitochondria protein homolog 1 8826900.0 2425600.0 2028900.0 4372400.0 True False 3139987.0157241523 1915989.9314535635 3576668.064612603 1.0 0.6101903994694362 1.1390709728102941 21.582327162712062 -6.7092235260260695 1.7979074160262003 0.760163299960036 1.1378031816106229 0.46142142721967094 0.16428385451496277 0.37664986128974015 2.3728301488314134 0.07272765125755234 0.18494109641340614 1.9533338401158326e-07 6.7092235260260695 0.37763988165058693 SALSGHLETVILGLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SALSGHLETVILGLLK 16 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 582334000.0 340440000.0 40734000.0 201160000.0 False True 329632918.54743433 56999298.625003844 148470161.3293558 1.0 0.17291749524342975 0.4504106021437628 28.296285082486868 -10.346625797071658 5.7553067895834475 1.0001195174907735 0.3116640487379855 0.8913537249524336 0.11328608650757573 0.00017376104369728345 1.9726134537072208e-05 0.10970754913493226 0.03656292720006984 4.5016756755604595e-11 10.346625797071658 -0.6884554687527881 SALSGHLETVILGLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SALSGHLETVILGLLK 16 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 2575240000.0 1026200000.0 708800000.0 840240000.0 False True 1556820425.2692358 582309102.1203232 674166195.7097251 1.0 0.3740374243995539 0.4330404359855024 30.535955397302025 -10.410078327688453 5.452166480924457 1.0003624356714274 0.4035389301925231 0.9927143260841005 0.024087878612200634 0.00010618301028579036 1.1488986813866369e-05 0.023336671829127843 0.007774329392540686 3.8897498462994566e-11 10.410078327688453 -0.5968235054789042 SALSGHLETVILGLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SALSGHLETVILGLLK 16 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 800390000.0 340440000.0 110390000.0 349560000.0 False True 283090944.0491836 109795307.15930067 422651379.8171728 1.0 0.38784464663138457 1.4929879909678152 28.076690357921144 -6.756337378750782 1.626107470709512 0.6428079121533479 1.496330625563875 0.6758764619970106 0.2573583450559064 0.2891241262114073 1.505862808744039 0.12492177903211364 0.3013203365124549 1.7525185406397459e-07 6.756337378750782 0.8535227134105272 SALSGHLETVILGLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SALSGHLETVILGLLK 16 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YKL9;H0YMW4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 2286180000.0 1026200000.0 744240000.0 515740000.0 False True 1328436129.4261744 702822389.7604611 421880611.9392785 1.0 0.5290599782648558 0.317576888037148 30.307081719394475 -12.020342112934669 0.13285895982463583 2.3656150714247124 3.0790960526813744e-13 0.9996952766066902 0.004979083938083002 5.519833473900134 0.0925092144070468 2.3409480447098416 0.2435293321237971 9.542405924328814e-13 12.020342112934669 -2.3656150714244046 SALTQSQSAK(ub)QQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SALTQSQSAKQQK 13 1 E9PMC9;Q7Z589-2;Q7Z589-6;Q7Z589;Q7Z589-5;Q7Z589-4;Q7Z589-7;H0YET8 E9PMC9 C11orf30;EMSY Protein EMSY 1 5986962.0 72822.0 1278100.0 4636040.0 True False 95470.34720925121 1087412.4619947807 4156347.052835862 1.0 11.390054543442668 43.53547645245294 16.542765085712173 -6.950756504717939 0.5504814890970623 0.5567016875948467 55.88020642222559 0.9992592839692386 0.4927832864511952 0.08318349934734698 0.03471694782978256 0.534524995849924 2.6669749834133665 1.1200656931256869e-07 6.950756504717939 55.323504734630745 SALTQSQSAK(ub)QQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SALTQSQSAKQQK 13 1 E9PMC9;Q7Z589-2;Q7Z589-6;Q7Z589;Q7Z589-5;Q7Z589-4;Q7Z589-7;H0YET8 E9PMC9 C11orf30;EMSY Protein EMSY 1 10593200.0 1134600.0 3216500.0 6242100.0 True False 1098582.7440486408 4500865.223825906 4607106.75101398 1.0 4.096974259070127 4.193682065344726 20.067212105387547 -10.29313728591781 0.7098888409796014 1.9719031101329923e-18 4.176626959389794 0.9998933546035622 0.015317385312474391 1.615391920311922 0.359262563077127 3.2284234700266103 0.01491712750312778 5.0916989064353324e-11 10.29313728591781 4.176626959389794 SALTQSQSAK(ub)QQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SALTQSQSAKQQK 13 1 E9PMC9;Q7Z589-2;Q7Z589-6;Q7Z589;Q7Z589-5;Q7Z589-4;Q7Z589-7;H0YET8 E9PMC9 C11orf30;EMSY Protein EMSY 1 5668162.0 72822.0 1642950.0 3952390.0 True False 99746.26134055393 1570359.0364908907 3018916.884027177 1.0 15.743537806688984 30.26596529487941 16.605975147235064 -7.608229184417761 0.3868509509954671 4.556711293979606e-19 36.895741603516264 0.997725665527057 0.5697948593592135 0.15568345851848892 0.06884472533635878 1.0973927148098561 3.2495365467915684 2.4647383105978177e-08 7.608229184417761 36.895741603516264 SALTQSQSAK(ub)QQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SALTQSQSAKQQK 13 1 E9PMC9;Q7Z589-2;Q7Z589-6;Q7Z589;Q7Z589-5;Q7Z589-4;Q7Z589-7;H0YET8 E9PMC9 C11orf30;EMSY Protein EMSY 1 6859510.0 1134600.0 2821720.0 2903190.0 True False 943470.171302444 2806518.8342924365 3510233.6061660913 1.0 2.974676804480301 3.720555999476142 19.847617380821823 -9.415212629245627 0.2995578316045596 2.534791589592184e-22 4.021996390543494 0.9986998160057305 0.04138763006703333 0.8014820692974267 0.11792435977172352 1.0771013374560439 0.2609341352483655 3.844035331758502e-10 9.415212629245627 4.021996390543494 SALYYVDLIGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SALYYVDLIGGK 12 0 C9JIF9;P13798;H7C393;H7C1U0;C9JLK2 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 17530500.0 4827400.0 6583700.0 6119400.0 False True 6328768.148608099 5601437.623061595 5486223.189429711 1.0 0.8850754983485265 0.8668706232564878 22.593493285590505 -13.999999999999972 0.25934894872912584 1.8384540863772132 0.8601752510916567 0.9995609989206499 0.001234862420107939 14.388472274111612 0.16115429162681666 6.320215660483172 0.007986321098662414 1.0000000000000655e-14 13.999999999999972 -0.9782788352855565 SALYYVDLIGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SALYYVDLIGGK 12 0 C9JIF9;P13798;H7C393;H7C1U0;C9JLK2 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 13866200.0 5425600.0 2379100.0 6061500.0 False True 5253367.297823294 3329087.0368426004 4473811.308897849 1.0 0.6337053642188679 0.8516083219141274 22.32481102574206 -10.274069646196082 5.604490735946715 1.0000219807588413 0.7426568430664923 0.6503102690624842 0.08895850996612804 2.443458282090152e-05 3.1650198445089603e-06 0.08614105733241029 0.028711235633517282 5.320229338796841e-11 10.274069646196082 -0.25736513769234903 SALYYVDLIGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SALYYVDLIGGK 12 0 C9JIF9;P13798;H7C393;H7C1U0;C9JLK2 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 17067200.0 4827400.0 5167200.0 7072600.0 False True 6612220.235579765 4938896.018354622 5402197.544769271 1.0 0.7469345911648351 0.8170020586580782 22.656703347113396 -9.874283065664194 6.036115839340746 1.000000034959223 0.7819683249113353 0.9281121649355345 0.02860492382168137 1.3437611665599578e-08 2.4956402510615295e-09 0.027696602728500132 0.009232199465011926 1.3357246304517638e-10 9.874283065664194 -0.2180317100478878 SALYYVDLIGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SALYYVDLIGGK 12 0 C9JIF9;P13798;H7C393;H7C1U0;C9JLK2 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 10652100.0 5425600.0 2143600.0 3082900.0 False True 4511626.7948339 2132052.0013287156 3727520.1362809315 1.0 0.47256834358951205 0.8262031204684703 22.105216301176338 -9.941860864946266 5.613834381899018 1.0000004023571545 0.6493857320284876 0.5672220454532652 0.144370793111201 7.270225499707859e-07 1.3691557668693324e-07 0.13978657973449787 0.04659547311627531 1.1432445377226243e-10 9.941860864946266 -0.3506146703286669 SANQMGVSAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SANQMGVSAKR 11 1 Q6P2C8;A0A494C0K7;Q6P2C8-2;A0A494C0P0 Q6P2C8 MED27 Mediator of RNA polymerase II transcription subunit 27 1 4114170.0 952170.0 1604600.0 1557400.0 True False 1248304.0908273973 1365199.934681813 1396255.1876356911 1.0 1.093643724084037 1.118521679048756 20.251537991415933 -13.999999999999512 0.18605716332399605 0.5046600838136271 1.1370951167953247 0.9994920559469351 0.0011500529770308765 12.289341644822368 0.13678008538450181 2.2041655530452284 0.017661325277893977 1.0000000000011248e-14 13.999999999999512 0.6324350329816976 SANQMGVSAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 SANQMGVSAKR 11 1 Q6P2C8;A0A494C0K7;Q6P2C8-2;A0A494C0P0 Q6P2C8 MED27 Mediator of RNA polymerase II transcription subunit 27 1 4976320.0 491760.0 624460.0 3860100.0 True False 746035.8724716412 513020.2340717512 3097149.5430580676 1.0 0.6876616165548426 4.15147536109371 19.50888547729356 -6.884882302116542 1.0521611823784933 0.7904185890218345 4.421180326987776 0.9774162514579675 0.23510288787471983 0.12339466830344824 0.24687960309188925 0.17129452599314585 0.41989330319413687 1.3035199967490844e-07 6.884882302116542 3.6307617379659414 up SANQMGVSAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SANQMGVSAKR 11 1 Q6P2C8;A0A494C0K7;Q6P2C8-2;A0A494C0P0 Q6P2C8 MED27 Mediator of RNA polymerase II transcription subunit 27 1 6390670.0 952170.0 1156700.0 4281800.0 True False 1304212.9804267287 1105593.1693046116 3270527.026439088 1.0 0.847709067381671 2.5076633000301807 20.314748052938825 -6.884468744344602 1.0545214587184006 0.8986280649099398 2.635888141474326 0.9771164918525915 0.11333351513562885 0.12374706193547692 0.24896871066587856 0.08242536242341722 0.20179998415942318 1.304761867414925e-07 6.884468744344602 1.7372600765643862 up SANQMGVSAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SANQMGVSAKR 11 1 Q6P2C8;A0A494C0K7;Q6P2C8-2;A0A494C0P0 Q6P2C8 MED27 Mediator of RNA polymerase II transcription subunit 27 1 3553930.0 491760.0 437270.0 2624900.0 True False 636593.0140387979 412935.5401087782 2147195.1337484242 1.0 0.64866489421389 3.372948000364894 19.28001179938601 -6.87449382548837 1.1101001656817702 0.7947450536681481 3.546699223432485 0.968963587719975 0.21316058542632477 0.13261660665402705 0.302742635427289 0.14858238997894863 0.3547768188564529 1.3350765706628828e-07 6.87449382548837 2.751954169764337 up SANSELGGIWSVGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SANSELGGIWSVGQR 15 0 E9PGT6;Q99627-2;Q99627 E9PGT6 COPS8 COP9 signalosome complex subunit 8 0 8844900.0 2587200.0 2839800.0 3417900.0 False True 3391844.254480437 2416112.909453698 3064248.4948118795 1.0 0.7123301449534859 0.903416626740505 21.693638495579258 -10.028469410701947 4.794395027822826 1.0000042236323667 0.8078733864586125 0.5740853375206626 0.07801072953506981 3.52200977478647e-06 7.137053666078462e-07 0.0755352252268185 0.025177854690803424 9.365491829088154e-11 10.028469410701947 -0.19213083717375423 SANSELGGIWSVGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SANSELGGIWSVGQR 15 0 E9PGT6;Q99627-2;Q99627 E9PGT6 COPS8 COP9 signalosome complex subunit 8 0 9204600.0 2587200.0 3393500.0 3223900.0 False True 3543757.756451083 3243563.9491961594 2462481.218304679 1.0 0.9152894108779167 0.6948785406739385 21.75684855710215 -6.954599642178959 0.5058342935083262 1.0041995329206208 0.5963670564942198 0.9995145530770501 0.0028335560393016176 0.08168966405266073 0.028712865108657823 0.003287672045327604 0.018186505878951202 1.1101977883299304e-07 6.954599642178959 -0.40783247642640097 SAPATGGVK(ub)KPHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAPATGGVKKPHR 13 2 Q71DI3;Q16695;P68431;Q5TEC6 Q71DI3;Q5TEC6 HIST2H3A;HIST3H3;HIST1H3A;HIST2H3PS2 Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3 1 53612000.0 17023000.0 15406000.0 21183000.0 True False 16482614.1829191 21557696.141228653 15634536.823621707 1.0 1.3079051600667115 0.9485471570294806 23.974441739841616 -6.679905086307328 1.9025499936486252 1.1948352036967513 0.9499265284056846 0.323566204869819 0.1305007093085077 0.43872175673504016 3.0703290042123847 0.05504523253969247 0.1451784658452123 2.0897527898491102e-07 6.679905086307328 -0.24490867529106675 SAPATGGVK(ub)KPHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAPATGGVKKPHR 13 2 Q71DI3;Q16695;P68431;Q5TEC6 Q71DI3;Q5TEC6 HIST2H3A;HIST3H3;HIST1H3A;HIST2H3PS2 Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3 1 6689400.0 2288400.0 2621000.0 1780000.0 True False 3471670.1044495422 2153262.0720335306 1428182.219798285 1.0 0.6202381007555283 0.4113818931032139 21.727198431482435 -10.213441937584491 0.12405841269200192 1.7982856039034054 1.3612900900242703e-09 0.9998423366874893 0.0030594296519100015 1.8928019064851793 0.061142048889982675 0.7085176655243325 0.23787886837821293 6.117275815825623e-11 10.213441937584491 -1.7982856025421152 SAPELK(ub)TGISDVFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAPELKTGISDVFAK 15 1 P19338 P19338 NCL Nucleolin 1 40171200.0 15335900.0 14412300.0 10423000.0 True False 20105513.413066857 12262041.018705398 9344527.94447592 1.0 0.609884501170516 0.4647744005583454 24.26108784138578 -13.999999999999998 0.1373399621232444 2.8596057448427747 0.2793049648089197 0.999613748670021 0.0044417794920265045 11.932213818050235 0.1159085239821751 5.956173026060822 0.16552855687699133 1.0000000000000041e-14 13.999999999999998 -2.580300780033855 SAPELK(ub)TGISDVFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAPELKTGISDVFAK 15 1 P19338 P19338 NCL Nucleolin 1 41189900.0 14567500.0 13258400.0 13364000.0 True False 14105062.686346347 18552548.261642598 9863567.488593725 1.0 1.315311294546844 0.699292708435931 23.749709741838675 -6.76758213680961 1.583879812313968 1.1814117720856347 0.6961526792398647 0.721179778284702 0.13280701062354341 0.27034885536888686 1.3381371969965967 0.06610922708886673 0.15770813125522035 1.7077247126755106e-07 6.76758213680961 -0.48525909284577007 SAPELK(ub)TGISDVFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAPELKTGISDVFAK 15 1 P19338 P19338 NCL Nucleolin 1 117125000.0 33693000.0 22454000.0 60978000.0 True False 51114744.28824436 18446908.266097244 48925671.57239316 1.0 0.3608921168043437 0.9571733607135612 25.60723616757214 -10.758859107743074 10.02468589555868 1.0013042203723788 0.6590327387589558 0.30360915072404826 0.24343079846160376 0.007116461656395292 0.00017118402486329838 0.2363882501680413 0.07856695236631384 1.7423720357943135e-11 10.758859107743074 -0.3422714816134229 SAPELK(ub)TGISDVFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAPELKTGISDVFAK 15 1 P19338 P19338 NCL Nucleolin 1 36887100.0 15335900.0 12913900.0 8637300.0 True False 21005996.667114332 12343321.197443452 6597347.6307773115 1.0 0.5876094047357143 0.3140697266274304 24.324297902908672 -8.301122519953418 0.2064789523579256 1.2765764394025878 2.194736743662763e-09 0.9997317498786334 0.0046176380984596695 0.09566708091450983 0.046225520957874314 0.1163312854199466 0.11675305842436015 4.9989348882144346e-09 8.301122519953418 -1.276576437207851 down SAPELK(ub)TGISDVFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAPELKTGISDVFAK 15 1 P19338 P19338 NCL Nucleolin 1 50059400.0 14567500.0 24655000.0 10836900.0 True False 12113521.699672433 24522178.62136569 13102845.685835708 1.0 2.0243641138669695 1.081671045852011 23.53011501727295 -6.626399901660933 2.0931107572699514 1.6766057677065807 1.0853711301265323 0.10484947367227448 0.43979356368568023 0.5684134021503345 4.740588612652775 0.17211598285407528 0.4874343698127416 2.3637421433479878e-07 6.626399901660933 -0.5912346375800484 SAPELK(ub)TGISDVFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAPELKTGISDVFAK 15 1 P19338 P19338 NCL Nucleolin 1 93883000.0 33693000.0 11275000.0 48915000.0 True False 43616252.68832205 10647536.338478455 40012971.910283886 1.0 0.24411854944451153 0.9173867410438283 25.37836248966459 -10.789544201031976 9.86963096265595 1.003510340634481 0.5807526452444287 0.3408107687768748 0.2748605882441177 0.02127312313975417 0.0004536182713296334 0.26666413264483524 0.08871087339985345 1.623513106368972e-11 10.789544201031976 -0.42275769539005226 SAPGGGSK(ub)VPQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAPGGGSKVPQK 12 1 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 1 4527200.0 0.0 2784800.0 1742400.0 True False 0.0 3896785.1625401545 1286013.1691204505 0.0 SAPGGGSK(ub)VPQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAPGGGSKVPQK 12 1 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 1 3218970.0 991450.0 1296100.0 931420.0 True False 1358015.857928816 1238834.0163704562 711437.779197041 1.0 0.9122382549051153 0.523880317776328 20.373068895756365 -6.942561743156418 0.6352836139071443 1.0042408013100337 0.4107569870397459 0.9984805638302642 0.008064377974060951 0.08661713019625682 0.049431695788151965 0.008011775029449091 0.03306641887763046 1.1414010213880968e-07 6.942561743156418 -0.5934838142702878 SAPSTGGVK(ub)K(ub)PHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAPSTGGVKKPHR 13 2 K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 K7EK07 H3F3B;H3F3A Histone H3;Histone H3.3 2 6506900.0 1355900.0 1549500.0 3601500.0 True False 1777598.0305542774 1318320.6399036923 3228851.3280274384 1.0 0.741630344568183 1.8164125255137924 20.761497692766454 -6.843233365502343 1.2672674770655654 0.862554414978921 1.8540918264140112 0.9298712648792815 0.12130493271301192 0.16506031491827405 0.5135155317937634 0.07501417435109836 0.1730002192592639 1.43471828902791e-07 6.843233365502343 0.9915374114350901 SAPSTGGVK(ub)K(ub)PHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAPSTGGVKKPHR 13 2 K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 K7EK07 H3F3B;H3F3A Histone H3;Histone H3.3 2 7691900.0 2196700.0 1897400.0 3597800.0 True False 2126966.9609127855 2655041.7148102825 2655428.2483135653 1.0 1.2482759551990756 1.2484576851038585 21.020366192797898 SAPSTGGVK(ub)K(ub)PHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAPSTGGVKKPHR 13 2 K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 K7EK07 H3F3B;H3F3A Histone H3;Histone H3.3 2 3805300.0 0.0 2613500.0 1191800.0 True False 0.0 2147100.5056312974 956240.2076155039 0.0 SAPSTGGVK(ub)K(ub)PHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAPSTGGVKKPHR 13 2 K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 K7EK07 H3F3B;H3F3A Histone H3;Histone H3.3 2 10915200.0 1355900.0 2939500.0 6619800.0 True False 1857212.8718197374 2809623.170373395 5056339.579060552 1.0 1.5128169812976073 2.7225417483275574 20.824707754289346 -6.95669401932002 0.4797678054727868 0.9708996347222504 3.314875384783412 0.9996272330854287 0.013942762245704763 0.08090401247304355 0.025661313091850678 0.017048737927223556 0.0997927740431351 1.1048567687762417e-07 6.95669401932002 2.3439757500611615 SAPSTGGVK(ub)KPHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAPSTGGVKKPHR 13 2 K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 K7EK07 H3F3B;H3F3A Histone H3;Histone H3.3 1 109971000.0 34255000.0 44325000.0 31391000.0 True False 33167593.775239028 62024203.65182145 23168755.390185982 1.0 1.8700242191860499 0.6985359127101469 24.98327101626966 -6.7078326207324634 1.8028886209063288 1.5360626013152088 0.7014632839709128 0.4547514238026249 0.36675226686131923 0.37948729024151695 2.4030937935507835 0.1619648502631343 0.4125583991261406 1.9595997675489004e-07 6.7078326207324634 -0.8345993173442959 SAPSTGGVK(ub)KPHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAPSTGGVKKPHR 13 2 K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 K7EK07 H3F3B;H3F3A Histone H3;Histone H3.3 1 115830000.0 34255000.0 62555000.0 19020000.0 True False 28484550.2538033 62218003.79880461 22996994.06145621 1.0 2.184271938451869 0.8073497336818796 24.763676291703938 -6.679102532065993 1.9052108811202821 1.7499093130823038 0.8126421674515588 0.31997812769524026 0.502021758335083 0.44050976084723426 3.0907179652916015 0.21150185029752935 0.5584365507111798 2.0936181176962226e-07 6.679102532065993 -0.937267145630745 SAPWNSFLPPPPPMPGPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAPWNSFLPPPPPMPGPR 18 0 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;Q16637-4;Q16637-2;B4DP61;A0A0G2JRX5;A0A0G2JRY6;H0YBZ9 A0A1W2PRV5 SMN1;SMN2 Survival motor neuron protein 0 3664270.0 750470.0 1220000.0 1693800.0 False True 983873.4375618191 1037980.7555227531 1518541.8240768812 1.0 1.0549941851210252 1.543432077849411 19.9081132181056 -6.928203498800872 0.7613839113911932 0.9920568258575119 1.6392709592863015 0.9961735307330809 0.015108812710272075 0.09358084661319352 0.08232586669293579 0.01362068522724 0.04463951313238974 1.1797676984660535e-07 6.928203498800872 0.6472141334287896 SAPWNSFLPPPPPMPGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAPWNSFLPPPPPMPGPR 18 0 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;Q16637-4;Q16637-2;B4DP61;A0A0G2JRX5;A0A0G2JRY6;H0YBZ9 A0A1W2PRV5 SMN1;SMN2 Survival motor neuron protein 0 5345670.0 750470.0 2104500.0 2490700.0 False True 1027939.0396891809 2011516.2313491467 1902447.957576682 1.0 1.9568438921799984 1.850740057651597 19.971323279628493 -10.034862475284504 4.660988090060076 0.9999716119524286 1.9037919749522227 0.9897689479237904 0.04331670917913835 14978856.931585494 0.03549833492251815 4610.500363874685 0.014828461690754581 9.228636170603195e-11 10.034862475284504 0.9038203629997942 SASASHQADIK(ub)EAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SASASHQADIKEAR 14 1 Q14739;C9JXK0;A0A494C1L1 Q14739 LBR Lamin-B receptor 1 6799700.0 2058600.0 2605500.0 2135600.0 True False 2698844.5355107603 2216769.556159452 1914628.5981217294 1.0 0.8213772697877632 0.7094253014315933 21.36391044338441 -11.874138518953922 0.04998745415497321 2.105735795215657 2.231496013964465e-11 0.9999872934627702 0.0004265142047872805 5.492272449904823 0.03778882735992462 1.188568418038717 0.5196490237909798 1.33616927514192e-12 11.874138518953922 -2.105735795193342 SASASHQADIK(ub)EAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SASASHQADIKEAR 14 1 Q14739;C9JXK0;A0A494C1L1 Q14739 LBR Lamin-B receptor 1 6695300.0 2392300.0 1893600.0 2409400.0 True False 2316357.7459788155 2649724.354993544 1778305.8595493655 1.0 1.143918446791499 0.7677164128194338 21.143426654469963 -6.802997927498089 1.4435093296921913 1.0791059657266713 0.7621222409182397 0.840829994771497 0.061834854249269045 0.21649832049340317 0.8902655352545173 0.03369364936164566 0.07822501496561232 1.5739903757066642e-07 6.802997927498089 -0.3169837248084316 SASASHQADIK(ub)EAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SASASHQADIKEAR 14 1 Q14739;C9JXK0;A0A494C1L1 Q14739 LBR Lamin-B receptor 1 6155800.0 2058600.0 2028400.0 2068800.0 True False 2819720.0515732104 1938778.5809781926 1580192.0482734335 1.0 0.6875783927189818 0.5604074232091922 21.4271205049073 -13.999999999999998 0.1236801647467277 2.485935736395621 0.3671461402310774 0.9996750915072027 0.0033292232010535047 11.95109236779811 0.10869005245969465 4.34509422214716 0.17157380934538097 1.0000000000000041e-14 13.999999999999998 -2.1187895961645435 SASASHQADIK(ub)EAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SASASHQADIKEAR 14 1 Q14739;C9JXK0;A0A494C1L1 Q14739 LBR Lamin-B receptor 1 6544300.0 2392300.0 3088300.0 1063700.0 True False 1989303.4468595425 3071662.714920444 1286114.752006888 1.0 1.5440895755595214 0.6465151176595211 20.92383192990424 -6.742626805889346 1.6772091443500072 1.3227495127997433 0.6456976810211328 0.6165905318578517 0.22859464707471833 0.31310018485457675 1.7303732177415925 0.10778219953715476 0.2637157463310456 1.8087277183845637e-07 6.742626805889346 -0.6770518317786105 SASK(ub)TGCDVQER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SASKTGCDVQER 12 1 H0YCA5;Q9BVQ7;Q9BVQ7-2 H0YCA5 SPATA5L1 Spermatogenesis-associated protein 5-like protein 1 1 1481590.0 344390.0 0.0 1137200.0 True False 333457.527959555 0.0 839333.2047312753 1.0 0.0 2.517061797546457 18.34714349340539 -6.798914024564685 1.4604109210177483 0.4474891277031262 2.5508548118264547 0.828942951377073 0.42797843645462796 0.22231624667284627 0.9362209433539586 0.23055930856105392 0.536538274052477 1.588861257585338e-07 6.798914024564685 2.1033656841233284 SASK(ub)TGCDVQER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SASKTGCDVQER 12 1 H0YCA5;Q9BVQ7;Q9BVQ7-2 H0YCA5 SPATA5L1 Spermatogenesis-associated protein 5-like protein 1 1 2282990.0 344390.0 383300.0 1555300.0 True False 286375.5440638537 381235.086820907 1880506.0391053008 1.0 1.3312417722928964 6.56657343158465 18.127548768839667 -6.91980073723967 0.8262150747810205 0.8836546204972768 7.406928061848842 0.9941251682412042 0.1954220397833584 0.09828899381725914 0.10622661696515975 0.16819869759211636 0.5028703662123417 1.2028161835047995e-07 6.91980073723967 6.523273441351566 up SASLVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SASLVTR 7 0 Q9H2K8 Q9H2K8 TAOK3 Serine/threonine-protein kinase TAO3 0 7631460.0 1415200.0 424460.0 5791800.0 False True 1855340.904816297 361132.22253212135 5192520.094868624 1.0 0.1946446723589475 2.7986878753059945 20.823252864796057 -6.823653511606097 1.3560757993982664 0.5674594525040024 2.8600800840352196 0.8925707262457301 0.3567950252319801 0.1887710955613221 0.6811014835545087 0.20670780903478053 0.47600830755450585 1.5008817899872212e-07 6.823653511606097 2.292620631531217 SASPYHGFTIVNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SASPYHGFTIVNR 13 0 Q9NPI6-2;Q9NPI6;A0A087WXD0;A0A087WVE6;A0A087WT55 Q9NPI6-2 DCP1A mRNA-decapping enzyme 1A 0 9657600.0 2910500.0 2517500.0 4229600.0 False True 3815693.685322098 2141898.8131381385 3791961.565188082 1.0 0.5613392975902185 0.993780391695144 21.863513929240877 -10.902597941376687 10.52202385281306 1.0210061467681097 0.7775598446429739 0.2607847176112126 0.17654333739465833 0.07565370537383743 0.0007003227602193257 0.14865109796846634 0.056979117134449045 1.2514170236994335e-11 10.902597941376687 -0.24344630212513585 SASVTPK(ub)INQLCSQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SASVTPKINQLCSQTK 16 1 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 7549400.0 1365900.0 2756500.0 3427000.0 True False 1790708.127394414 2345240.9447528464 3072406.914105249 1.0 1.3096723630585796 1.7157496898033195 20.77209877684595 -6.9673948527315135 0.3142465017714214 0.9404962063458879 2.097913744746933 0.9999543432044843 0.0019803665951766036 0.07715741178476308 0.012041556546481928 0.0063054528356090486 0.035906669739717983 1.0779662090764443e-07 6.9673948527315135 1.1574175384010452 SATADQEFSK(ub)EDMAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SATADQEFSKEDMAK 15 1 Q9NVE7;H0YA26;E9PHT6 Q9NVE7 PANK4 Pantothenate kinase 4 1 5513000.0 1449800.0 1747000.0 2316200.0 True False 1900701.8398831731 1486354.4097526644 2076541.8425592585 1.0 0.7820029310036462 1.0925131964342674 20.858100805750947 -6.718049611824815 1.7666901839841678 0.8670935063696819 1.091964721387637 0.5031155920922602 0.09175686316306886 0.35913107649015974 2.189642717305792 0.04125909376013755 0.1038001489556137 1.9140372616272072e-07 6.718049611824815 0.22487121501795504 SATADQEFSK(ub)EDMAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SATADQEFSKEDMAK 15 1 Q9NVE7;H0YA26;E9PHT6 Q9NVE7 PANK4 Pantothenate kinase 4 1 7277700.0 1596100.0 2118200.0 3563400.0 True False 1545432.67916097 2964008.306267072 2630038.640291441 1.0 1.9179148637365815 1.7018137870096768 20.559579379420672 -10.19200476160311 4.707968555994081 0.9998728266555341 1.8098643253777449 0.9493059717506283 0.08822289515699021 0.00011778223437982615 2.0214069833541995e-05 0.08543469830484737 0.02847381697252661 6.426806709298674e-11 10.19200476160311 0.8099914987222108 SATADQEFSK(ub)EDMAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SATADQEFSKEDMAK 15 1 Q9NVE7;H0YA26;E9PHT6 Q9NVE7 PANK4 Pantothenate kinase 4 1 24987600.0 6039800.0 6135800.0 12812000.0 True False 9162818.168525757 5040818.550775793 10279702.584300924 1.0 0.5501384462796592 1.121893111402304 23.127359959398422 -6.696844094036172 1.8416698586163258 0.7198101484159521 1.120124230139065 0.40289693048963515 0.1900016727057676 0.4020819121125749 2.6489726002324456 0.0823672723462147 0.21269177510815387 2.009814179777276e-07 6.696844094036172 0.4003140817231129 SATADQEFSK(ub)EDMAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SATADQEFSKEDMAK 15 1 Q9NVE7;H0YA26;E9PHT6 Q9NVE7 PANK4 Pantothenate kinase 4 1 5257300.0 1449800.0 1568100.0 2239400.0 True False 1985830.2393718257 1498816.156986741 1710499.8418907223 1.0 0.7547554303840489 0.8613525003183564 20.92131086727384 -10.100917112249546 4.675581639624303 1.0000120072532501 0.8080539653477636 0.8121434779302638 0.04351807158091723 5.447247646275783e-06 1.047449268147164e-06 0.04213882686280152 0.014045397205996625 7.926525986272982e-11 10.100917112249546 -0.1919580419054865 SATADQEFSK(ub)EDMAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SATADQEFSKEDMAK 15 1 Q9NVE7;H0YA26;E9PHT6 Q9NVE7 PANK4 Pantothenate kinase 4 1 6527400.0 1596100.0 2675700.0 2255600.0 True False 1327227.8692189597 2661285.4730151333 2727235.531283944 1.0 2.0051458643505073 2.054835943799804 20.33998465485495 -10.95925639434791 0.5312132342127118 1.8702222777578935e-18 2.0513320398484476 0.9998278252616696 0.006376617734492782 2.7470050735935123 0.25864961859603985 3.392905319035174 0.009560263316618946 1.0983572110552732e-11 10.95925639434791 2.0513320398484476 SATADQEFSK(ub)EDMAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SATADQEFSKEDMAK 15 1 Q9NVE7;H0YA26;E9PHT6 Q9NVE7 PANK4 Pantothenate kinase 4 1 27657600.0 6039800.0 5060800.0 16557000.0 True False 7818640.1622570725 4779162.0311992625 13543795.889166312 1.0 0.6112523318658039 1.7322444322922403 22.89848628149087 -6.813044210469654 1.4016722313702845 0.7888869590114512 1.753257073979028 0.8676382049291087 0.16908316726103564 0.2026751936626398 0.7842010542581391 0.09483567500023524 0.21909035537502516 1.537998066639944e-07 6.813044210469654 0.9643701149675769 SATLETK(ub)PESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SATLETKPESK 11 1 A0A2R8YFL3;A0A2R8Y7R1;A0A2R8Y4U4;P15260 A0A2R8YFL3 IFNGR1 Interferon gamma receptor 1 1 2567270.0 803580.0 824920.0 938770.0 True False 1053501.1618797907 701845.1515129755 841635.0857177066 1.0 0.6662025414956867 0.7988933626005256 20.00676047459215 -10.067055389300824 4.898839362129332 1.000007192835834 0.732547952502138 0.8441609068965179 0.05417080088446275 4.255705054370388e-06 8.105221370701135e-07 0.052452062831660054 0.017483550805188996 8.569285468119935e-11 10.067055389300824 -0.26745924033369606 SATLETK(ub)PESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SATLETKPESK 11 1 A0A2R8YFL3;A0A2R8Y7R1;A0A2R8Y4U4;P15260 A0A2R8YFL3 IFNGR1 Interferon gamma receptor 1 1 3578940.0 580540.0 1225200.0 1773200.0 True False 880721.6231590353 1006553.4874687068 1422726.2427788326 1.0 1.1428735947896098 1.6154096883368168 19.748326561287612 -6.949239555845433 0.5671290834635194 0.9940352589254967 1.787109458216512 0.9991402598656923 0.007710957114436454 0.08379251326945529 0.037236992205622835 0.008196293915083155 0.03934428453520053 1.1239848154836482e-07 6.949239555845433 0.7930741992910152 SATLETK(ub)PESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SATLETKPESK 11 1 A0A2R8YFL3;A0A2R8Y7R1;A0A2R8Y4U4;P15260 A0A2R8YFL3 IFNGR1 Interferon gamma receptor 1 1 1346290.0 749310.0 0.0 596980.0 True False 623084.4650613725 0.0 721805.7578763478 1.0 0.0 1.1584396632409242 19.24906822206062 -10.683134476797827 4.528645788664249 1.015455514607326 0.5792198316231388 0.14959826679292731 0.4729310121237663 0.07456885208040742 0.005217514860089487 0.462689386923097 0.15263782782167937 2.0742711318340684e-11 10.683134476797827 -0.43623568298418725 SATLETK(ub)PESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SATLETKPESK 11 1 A0A2R8YFL3;A0A2R8Y7R1;A0A2R8Y4U4;P15260 A0A2R8YFL3 IFNGR1 Interferon gamma receptor 1 1 2819510.0 580540.0 793670.0 1445300.0 True False 751520.4741542303 749501.5668079989 1182270.230030324 1.0 0.9973135697354041 1.5731710188745882 19.519452883380062 -6.905850324766389 0.9235407225604761 0.979746746415247 1.6413432982954943 0.9892587458970147 0.02806891228793988 0.10722650344371666 0.15412986451136826 0.02251888602429372 0.06051169313366413 1.242080304344304e-07 6.905850324766389 0.6615965518802474 SATLLQLITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SATLLQLITK 10 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 15956700.0 4095800.0 5876500.0 5984400.0 False True 5369633.463783625 4999749.106417594 5365191.694418282 1.0 0.9311155296053675 0.9991727984050865 22.356392181179285 -9.91049767259893 4.41916871426326 1.0000005220311263 0.9651441641063359 0.2591145283605979 0.02778426369245855 37956794.319958344 509.8531806650723 206.2564512946346 0.00951129247239725 1.2288597720683134e-10 9.91049767259893 -0.03485635792479047 SATLLQLITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SATLLQLITK 10 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 14359300.0 5919700.0 2973200.0 5466400.0 False True 5731782.363779952 4160414.26503317 4034585.851515168 1.0 0.7258500063302284 0.7038972514047916 22.45055240072181 -13.999999999999998 0.35787263454726453 4.539865857972107 0.7011729866086109 0.9997694158095457 0.002045537520687207 21.469203906445703 0.19316716366956224 57.987250193872825 0.006379180166669875 1.0000000000000041e-14 13.999999999999998 -3.8386928713634965 SATLLQLITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SATLLQLITK 10 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 15713800.0 4095800.0 3963300.0 7654700.0 False True 5610127.944833166 3788188.301119533 5846817.513495092 1.0 0.675240981733472 1.0421896917484588 22.419602242702176 -6.67312432852033 1.926163608865199 0.7932662579509415 1.0407320098109378 0.292974986710956 0.137852244133162 0.4540097463500311 3.2502842866403445 0.05755388054036686 0.15315330990078585 2.1226367129470216e-07 6.67312432852033 0.2474657518599963 SATLLQLITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SATLLQLITK 10 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 10940300.0 5919700.0 2372400.0 2648200.0 False True 4922492.83717528 2359619.4103154726 3201926.3761066417 1.0 0.47935456451969466 0.6504684683185914 22.230957676156088 -10.511588851081926 7.0422365050848 1.0001581505715 0.5649115164191435 0.8960533372346734 0.0698569587004975 0.00017351938614032476 1.2034304011746404e-05 0.06766284939233486 0.022546236471977173 3.079010351025733e-11 10.511588851081926 -0.43524663415235654 SATNGK(ub)SETITADVNHNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SATNGKSETITADVNHNLK 19 1 Q16222 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 1 3004720.0 1043800.0 1108600.0 852320.0 True False 867965.9481804084 1102627.7517601284 1030536.171317579 1.0 1.2703583061889256 1.187300231625423 19.727278918771425 -10.071885369240036 4.320087492168448 0.9999780782612293 1.228829268938592 0.9100752658855504 0.033908317055481814 23537416.632220745 0.11914335894221506 5241.328145526992 0.011607718820825712 8.474510668568277e-11 10.071885369240036 0.2288511906773627 SATSSSVSNVVITK(ub)NVFEETSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SATSSSVSNVVITKNVFEETSVK 23 1 P42566;B1AUU8;P42566-2 P42566 EPS15 Epidermal growth factor receptor substrate 15 1 13721200.0 4463500.0 6697600.0 2560100.0 True False 3711598.016577168 6661518.699430496 3095405.073435017 1.0 1.7947845293800815 0.8339817673169242 21.823609037630558 -6.687064001888806 1.8770560801092033 1.4996588410282299 0.8374375517260199 0.3565779379235372 0.3363434673253677 0.4230380405095399 2.887531405983318 0.14347741961628566 0.37498514059187016 2.0555876421319603e-07 6.687064001888806 -0.66222128930221 SAVADK(ub)HELLSLASSNHLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAVADKHELLSLASSNHLGK 20 1 A0A087WZK9;B3KS98;O15372;E5RJT0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 21414500.0 3172600.0 4884900.0 13357000.0 True False 3071887.5495934403 6835466.044416966 9858400.998589221 1.0 2.225168055165831 3.209232382185984 21.550693974636758 -7.197766067897236 0.16491526137682672 1.887513445853851e-15 5.240492709085733 0.9999953252964096 0.001953895410032593 0.09292699788682697 0.007653835516894891 0.07084268296256578 0.16002764053994273 6.342112362448242e-08 7.197766067897236 5.240492709085731 SAVADK(ub)HELLSLASSNHLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAVADKHELLSLASSNHLGK 20 1 A0A087WZK9;B3KS98;O15372;E5RJT0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 15683400.0 1975700.0 6694400.0 7013300.0 True False 2706169.681284947 6398619.27257958 5356902.983447444 1.0 2.3644560490166233 1.9795148177492967 21.367820870823966 -10.16145406791718 5.161699794261206 0.9999449710492861 2.171985433383913 0.9251458467524476 0.15715159959727562 9.952528704756182e-05 1.6168414417090083e-05 0.15216846007647852 0.05072046067202924 6.895185145367019e-11 10.16145406791718 1.172040462334627 SAVADK(ub)HELLSLASSNHLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAVADKHELLSLASSNHLGK 20 1 A0A087WZK9;B3KS98;O15372;E5RJT0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 14704400.0 3172600.0 4150800.0 7381000.0 True False 2638157.4700106937 4128438.816530713 8924332.974111892 1.0 1.5648947659344907 3.3827901008788976 21.331099250071034 -6.949862950342369 0.5603450338812318 0.9762671898781546 4.058349451550675 0.9991904927278253 0.028924542681185855 0.08354079963534833 0.03619030599876049 0.030992551840143674 0.15112775093954703 1.1223725838541849e-07 6.949862950342369 3.0820822616725203 SAVADK(ub)HELLSLASSNHLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAVADKHELLSLASSNHLGK 20 1 A0A087WZK9;B3KS98;O15372;E5RJT0 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 1 63212900.0 5664900.0 14195000.0 43353000.0 True False 7333324.721873251 13405035.77159214 35463198.839344546 1.0 1.8279615699559408 4.835896429564584 22.806035993096945 -6.947088012641605 0.5899478239434073 0.9652275001622938 5.849972020479548 0.9989524986375422 0.053342263177685194 0.0846765587736599 0.040967211781606755 0.05530483600965782 0.25198607671391604 1.1295669772765491e-07 6.947088012641605 4.884744520317255 SAVEDEGLK(ub)GK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAVEDEGLKGK 11 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 60543200.0 2795200.0 29718000.0 28030000.0 True False 4240522.756492466 24414590.71220624 22489858.214014567 1.0 5.757448341675848 5.303557958645877 22.015810695365282 -10.244581775789438 4.688924467239587 0.9987026342917398 5.530503150070559 0.9925284054333199 0.18529997299304873 0.002519035204757844 0.00040583464015931997 0.17943114129273446 0.059805309112232204 5.694009982657963e-11 10.244581775789438 4.531800515778819 SAVEDEGLK(ub)GK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAVEDEGLKGK 11 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 5919310.0 839010.0 1420800.0 3659500.0 True False 697673.9894451472 1413145.8683932808 4424684.530383752 1.0 2.025510323979744 6.34205172806092 19.41219352278731 -6.943705058951225 0.6241426256164502 0.952862578301341 7.6450132052535995 0.99861003780084 0.08629816825490653 0.08611626414938726 0.04721244018669366 0.08658328500902827 0.36588919991855323 1.138400141476243e-07 6.943705058951225 6.692150626952259 SAVEDEGLK(ub)GK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAVEDEGLKGK 11 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 43865200.0 2795200.0 22579000.0 18491000.0 True False 3618441.5016293535 21322458.801463865 15125827.733682115 1.0 5.892718948713843 4.180205131648828 21.78693701745773 -9.580183603823482 7.7110352702773195 0.9998955448712262 5.036462040181654 0.8810587354056478 0.6991308408146681 0.0 0.0 0.6769305246480365 0.22564350821601212 2.629156245804642e-10 9.580183603823482 4.036566495310428 SAVENCQDSWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAVENCQDSWR 11 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 16727500.0 1138400.0 8008800.0 7580300.0 False True 1492453.4242812826 6813918.258057899 6795963.271372051 1.0 4.565581844766286 4.553551327502745 20.50925447863208 -10.1094737773934 4.701149768312968 0.999768359796291 4.559566586184444 0.9999914329257175 0.0049114382822615455 1.1927238195087565e-05 2.2593554380756268e-06 0.004755758154348984 0.001585159864501845 7.771882438345592e-11 10.1094737773934 3.5597982263881534 SAVENCQDSWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAVENCQDSWR 11 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 5062190.0 2730700.0 607490.0 1724000.0 False True 2644015.423209611 850063.9250184998 1272432.681108617 1.0 0.32150490407752397 0.4812500978394413 21.334299161798796 -10.344167489747901 8.720264388298032 1.0000011431945641 0.401377500962108 0.9492992998236658 0.0652157022631213 1.4494929715332905e-06 1.0903508141801125e-07 0.06314495307039183 0.021048277398024184 4.52722949372284e-11 10.344167489747901 -0.5986236422324561 SAVENCQDSWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAVENCQDSWR 11 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 51548800.0 4107400.0 43756000.0 3685400.0 False True 6231226.091162407 35947399.932811625 2956979.0746317953 1.0 5.768912796118076 0.4745420935416876 22.571084633312022 -6.669393978612492 1.939721405563814 4.045560524565034 0.49607848334582844 0.27633232697863874 2.0260116386144067 0.4624766808311597 3.3541859985012623 0.8410852714716862 2.2487823104823006 2.140947518082022e-07 6.669393978612492 -3.5494820412192056 SAVENCQDSWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAVENCQDSWR 11 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 15078200.0 1138400.0 6972600.0 6967200.0 False True 1559297.2441032457 6664527.476695204 5321690.853988142 1.0 4.274058395150941 3.4128777397080916 20.57246454015497 -9.792420118565287 7.526208611025998 0.9999999976807422 3.843468067429527 0.9356336452074046 0.35157553036513 1.243213166240097e-08 4.043890557841097e-09 0.3404115460457935 0.11347051450317676 1.612797648058908e-10 9.792420118565287 2.8434680697487846 SAVENCQDSWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAVENCQDSWR 11 0 P52209-2;P52209 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 10699700.0 4107400.0 3055700.0 3536600.0 False True 5317110.268958362 2885647.6088238214 2892975.088580399 1.0 0.5427097545203118 0.5440878488960023 22.34221095540447 -10.003964761494318 4.90106096383532 1.000005941279481 0.5433988016998216 0.99999316737004 0.0005626047019946264 775795.5498857747 0.06672682911788957 52.49984578407807 0.00019259454950290857 9.909123439195258e-11 10.003964761494318 -0.4566071395796595 SAVLISSKPGCFIAGADINMLAACK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAVLISSKPGCFIAGADINMLAACK 25 1 H0YFD6;P40939;A0A2R8Y4F5;A0A2R8YG21;A0A2R8Y688 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 41852000.0 14833000.0 13796000.0 13223000.0 False True 19201610.902142297 13028240.472341342 10816549.679437473 1.0 0.6784972645648079 0.5633146997177557 24.194724013858107 -13.999999999999998 0.1429166042237323 2.540180071981875 0.42565750061870433 0.9995915656987265 0.0037345504848424133 11.938101016881458 0.11864880617470379 5.1199269862449235 0.12332074264155152 1.0000000000000041e-14 13.999999999999998 -2.1145225713631706 SAVPPGADK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAVPPGADKK 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 55977300.0 13262000.0 29612900.0 13102400.0 True False 17386610.429390673 25194770.750180084 11746689.33509558 1.0 1.4490904280911674 0.6756169860019836 24.051473366646196 -6.749269107223306 1.6523345109688143 1.2642942609327399 0.6741421288822513 0.6459385870650964 0.18870463722180456 0.3013055582256238 1.618256424532163 0.09022203667041116 0.2192215418582285 1.7812746723107185e-07 6.749269107223306 -0.5901521320504886 SAVPPGADK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAVPPGADKK 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 70251300.0 27348100.0 33093300.0 9809900.0 True False 26479949.535093077 46307627.26927963 7240392.899308261 1.0 1.7487807976336787 0.27342925596262135 24.658397036902727 -6.768711809385305 1.5791955511089621 1.4301817503427772 0.2654944325361942 0.7256844809988174 0.3154724812357342 0.2685140562203448 1.3213241872623036 0.15747445650094652 0.3753281410077072 1.7032884073976487e-07 6.768711809385305 -1.164687317806583 SAVPPGADK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAVPPGADKK 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 35439060.0 7126300.0 14721070.0 13591690.0 True False 10811118.102315487 12093980.042255128 10905286.514050653 1.0 1.1186613565589374 1.0087103304990255 23.366012400720663 -10.861048125708153 3.302040083761805 0.9778579285080783 1.06368584353327 0.30907155597354974 0.04488731843621666 0.009623929407828894 0.00040498085079337736 0.057165764711693594 0.01448731972833095 1.377056863895384e-11 10.861048125708153 0.0858279150251916 SAVPPGADK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAVPPGADKK 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 41545300.0 13262000.0 22137000.0 6146300.0 True False 18165319.792074155 21158914.142730337 4694670.527021946 1.0 1.1647972281755445 0.2584413916605153 24.114683428169087 -6.859823152102864 1.1866348934546571 1.0893703908313 0.2147010659082989 0.9534226514771332 0.0850755654808331 0.1469865746448819 0.39338769058863987 0.05592241098205397 0.13051318475253515 1.380946481657641e-07 6.859823152102864 -0.8746693249230011 down SAVPPGADK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAVPPGADKK 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 179677160.0 27348100.0 141568100.0 10760960.0 True False 22741156.876252722 140805444.54623243 13011026.98294258 1.0 6.191657060915288 0.5721356681079511 24.438802312337003 -6.663948197400013 1.9591185721550308 4.330946042944796 0.5954899759388942 0.25241787434776874 2.2084327592055764 0.47515605924313753 3.5099253036864626 0.9094847767243693 2.4489938422964457 2.1679626837579696e-07 6.663948197400013 -3.735456067005902 SAVPPGADK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAVPPGADKK 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 15135260.0 7126300.0 3098200.0 4910760.0 True False 9225135.830373947 2925782.446463321 4017052.0686526857 1.0 0.3171533189603694 0.4354463871877594 23.137138722813113 -9.974494827511757 5.979719636773948 1.0000004599836745 0.3762998530800375 0.9737296084566162 0.048292942877954256 35108224.712948635 58562374.131416716 158.7044339112177 0.016531965581115894 1.0604865687921799e-10 9.974494827511757 -0.623700606903637 SAVPPGADK(ub)K(ub)AEAGAGSATEFQFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAVPPGADKKAEAGAGSATEFQFR 24 2 P46783 P46783 RPS10 40S ribosomal protein S10 2 1142641400.0 367987600.0 531904800.0 242749000.0 True False 482435307.196988 452546677.188671 217631662.09283164 1.0 0.938046346188935 0.45111056103521935 28.845760254342736 -6.93042664181514 0.743281455828229 1.0072888055479552 0.35005023059625157 0.9966214396636376 0.014267045620921154 0.09241689623605491 0.07659923260443174 0.013031103292536459 0.04395637595876156 1.1737439268990019e-07 6.93042664181514 -0.6572385749517036 down SAVPPGADK(ub)K(ub)AEAGAGSATEFQFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAVPPGADKKAEAGAGSATEFQFR 24 2 P46783 P46783 RPS10 40S ribosomal protein S10 2 1052123000.0 486623000.0 324263600.0 241236400.0 True False 471175419.2289636 453743746.49233514 178049349.903127 1.0 0.9630038579577138 0.3778833585896498 28.811689036209795 -6.919792478315198 0.8262702169814937 1.0130073350722706 0.28397817896914446 0.994122908586171 0.021844820198888257 0.09829419751304717 0.10625023866558836 0.01880083880297026 0.05620572178869488 1.2028390575289553e-07 6.919792478315198 -0.7290291561031261 down SAVPPGADK(ub)K(ub)AEAGAGSATEFQFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAVPPGADKKAEAGAGSATEFQFR 24 2 P46783 P46783 RPS10 40S ribosomal protein S10 2 1331469000.0 627400000.0 441311000.0 262758000.0 True False 951811669.0839202 362555604.0714191 210823766.12907726 1.0 0.3809110729020207 0.22149735391664876 29.826100900954213 -13.99999999999977 0.1904914974477336 4.324342956694473 0.10769622694353068 0.999489144836352 0.007589393778898201 12.35876566337212 0.1384088352078367 15.25234583148949 0.10920398306156706 1.0000000000005276e-14 13.99999999999977 -4.216646729750942 SAVPPGADK(ub)K(ub)AEAGAGSATEFQFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAVPPGADKKAEAGAGSATEFQFR 24 2 P46783 P46783 RPS10 40S ribosomal protein S10 2 995427800.0 367987600.0 352096000.0 275344200.0 True False 504042560.2109696 336539234.49423057 210313570.85180274 1.0 0.66768019421489 0.4172535961323879 28.908970315865627 -7.671061503824313 0.17862245691893 1.2540542769244116 7.550181227918202e-14 0.999949274488858 0.0016999629497480332 0.13354409215790708 0.02117355121712367 0.04951172202850825 0.08185183927451656 2.132742857430822e-08 7.671061503824313 -1.2540542769243361 down SAVPPGADK(ub)K(ub)AEAGAGSATEFQFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAVPPGADKKAEAGAGSATEFQFR 24 2 P46783 P46783 RPS10 40S ribosomal protein S10 2 1054915000.0 486623000.0 482154000.0 86138000.0 True False 404648585.55412436 479556540.70192474 104149057.54288729 1.0 1.1851185394487953 0.25738149411857186 28.592094311644072 -6.854821433923112 1.2115317109101111 1.0993585603806308 0.2166807630684043 0.9470452131514144 0.09225345517462932 0.1522263275152032 0.4275469073121299 0.05950128474092971 0.13818909832543233 1.396942614927754e-07 6.854821433923112 -0.8826777973122265 down SAVPPGADK(ub)K(ub)AEAGAGSATEFQFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAVPPGADKKAEAGAGSATEFQFR 24 2 P46783 P46783 RPS10 40S ribosomal protein S10 2 1248531000.0 627400000.0 526307000.0 94824000.0 True False 812181667.9029255 497017552.78896433 77567004.97640319 1.0 0.6119536705036409 0.09550450107632107 29.597227223046662 -7.587271711285728 0.5170750643198846 1.0131148075795653 5.884292560965303e-24 0.9958787072619375 0.023784900452612126 0.11754444760427656 0.08497082287408876 0.02629987715430386 0.07264390983174858 2.5865941363174428e-08 7.587271711285728 -1.0131148075795653 down SAVPPGADKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAVPPGADKK 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 0 4568000.0 1254500.0 2209100.0 1104400.0 False True 1644661.648595281 1879510.8910043552 990127.2821528547 1.0 1.1427948676310784 0.6020249107155448 20.64935938240213 -6.836501520709301 1.2985415292917377 1.0760306702018718 0.5854351434324166 0.9182709847133832 0.06541428545621863 0.17292424228847852 0.5679144877046953 0.039522098180288796 0.09098375988990594 1.4571306024875154e-07 6.836501520709301 -0.49059552676945517 SAVPPGADKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAVPPGADKK 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 0 5626760.0 2129900.0 2846600.0 650260.0 False True 2062287.490348315 3983262.2248228947 479937.3986181491 1.0 1.931477664227179 0.23272089893591358 20.97581403296564 -6.757787505803468 1.6206310552189174 1.5425053561792834 0.22712264609560506 0.6820414274047244 0.39166615617778183 0.28659245886688556 1.4829897944293329 0.19072700818002458 0.4593845787230916 1.7466765682144523e-07 6.757787505803468 -1.3153827100836784 SAVPPGADKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAVPPGADKK 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 0 3801140.0 1254500.0 1881200.0 665440.0 False True 1718322.5515877728 1798082.3637034965 508276.7771669914 1.0 1.0464172527108042 0.2957982345615676 20.712569443925023 -6.892175748998422 1.0094012103766108 1.0382531242388815 0.2284119154048298 0.9822554871864054 0.045747506325554126 0.11739642231806478 0.2116676103736541 0.034429603542788775 0.0865357867313035 1.2818117579175132e-07 6.892175748998422 -0.8098412088340516 down SAVPPGADKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAVPPGADKK 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 0 5129420.0 2129900.0 2551400.0 448120.0 False True 1771106.2205685473 2537655.101786754 541819.8201272214 1.0 1.432807966182929 0.30592169675362013 20.756219308399917 -6.802597467251946 1.4453321612932324 1.2380202546097325 0.28935972889135714 0.8396283078474119 0.18587663265407292 0.21707620708972078 0.8949764262709761 0.1011611303446284 0.23489613572940857 1.575442411816371e-07 6.802597467251946 -0.9486605257183753 down SAVPPGADKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAVPPGADKK 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 255193000.0 73791000.0 128660000.0 52742000.0 True False 96740715.59306039 109464429.5127521 47284763.776988335 1.0 1.1315238763915494 0.4887783131137007 26.527619873679633 -6.853398402242144 1.2186452758828925 1.0704434239145832 0.4613588424086272 0.9450962802318759 0.06496207120761978 0.1537601091818792 0.4377242618931125 0.04167401226689942 0.09666543603123667 1.401527416388234e-07 6.853398402242144 -0.609084581505956 down SAVPPGADKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAVPPGADKK 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 294438940.0 107500000.0 147129940.0 39809000.0 True False 104087471.34252505 205879692.31450135 29381828.65559917 1.0 1.977948831488127 0.2822801656782606 26.63322118585554 -6.750289874178048 1.6486178224120838 1.5748205652440783 0.27879011512724755 0.6503434196839395 0.41094558837884876 0.2995060879212478 1.6016856398900101 0.19689803775891365 0.4778987077674489 1.7770928757589786e-07 6.750289874178048 -1.2960304501168307 SAVPPGADKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAVPPGADKK 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 227057000.0 73791000.0 100120000.0 53146000.0 True False 101073526.82679412 95696367.34743468 40594009.37622771 1.0 0.9467995265607574 0.40162850402749006 26.590829935202525 -6.925800027765921 0.7804965962696152 1.009706837283668 0.30080647986706194 0.9956464280579332 0.017842031057454317 0.09487804298303439 0.08879913317967544 0.015865730897396457 0.050515542508184554 1.186314864766479e-07 6.925800027765921 -0.708900357416606 down SAVPPGADKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAVPPGADKK 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 132177160.0 107500000.0 563160.0 24114000.0 True False 89391013.05747643 560126.1453014918 29156125.909461334 1.0 0.006266023016668836 0.32616394995674336 26.413626461289816 -10.453219482989521 6.0209974595711 1.0004254906107184 0.16621498648672164 0.9005749519457661 0.13059778179621975 0.0007462809890420805 6.777130725173633e-05 0.12651085003048176 0.042150252829032335 3.5219283545630913e-11 10.453219482989521 -0.8342105041239968 SAVPPGADKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAVPPGADKK 10 1 A0A1W2PQS6;F6U211;A0A2R8Y7H1;A0A2R8YFH6;S4R435;P46783 A0A1W2PQS6;P46783 RPS10;RPS10-NUDT3 40S ribosomal protein S10 1 89437640.0 60301300.0 28101340.0 1035000.0 True False 78061221.56632878 26537475.72593681 846640.6199968081 1.0 0.3399572181097354 0.010845854100264314 26.21810270364604 -8.599053176992735 0.48122504506383684 1.0686517863552027 3.20144743699779e-21 0.9947682310562838 0.029748627260376102 0.2602162195538703 0.1735042886622643 0.09608635253234141 0.06671121081725856 2.517368670811051e-09 8.599053176992735 -1.0686517863552027 SAYALCTFALSTGDPSQPVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAYALCTFALSTGDPSQPVR 20 0 Q9BY32;Q9BY32-3;Q9BY32-2 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 0 6942700.0 1813600.0 3413500.0 1715600.0 False True 2377647.1629273845 2904219.1057187878 1538086.1691972457 1.0 1.2214676555048993 0.6468942041440403 21.181103207846384 -6.802213192743164 1.4469383312817694 1.1218517998851834 0.63852940940165 0.8385377303239253 0.09507622226817035 0.21761155556862638 0.8992306897516834 0.05168814373530733 0.12004494030268698 1.576837019163838e-07 6.802213192743164 -0.4833223904835333 SAYALCTFALSTGDPSQPVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAYALCTFALSTGDPSQPVR 20 0 Q9BY32;Q9BY32-3;Q9BY32-2 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 0 10206200.0 4725400.0 2982800.0 2498000.0 False True 4575394.763553187 4173847.5950965155 1843698.8616063383 1.0 0.9122376998690194 0.4029595164755899 22.125464793343948 -6.936545875838388 0.6909505656930562 1.0061992212917994 0.27853966028127375 0.9976755670075104 0.01269006198640108 0.0893783803446856 0.06205413189400734 0.012050650878061616 0.044540312703105024 1.1573217742391394e-07 6.936545875838388 -0.7276595610105256 down SAYALCTFALSTGDPSQPVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SAYALCTFALSTGDPSQPVR 20 0 Q9BY32;Q9BY32-3;Q9BY32-2 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 0 33790100.0 5703700.0 19615000.0 8471400.0 False True 8652929.896324432 16114549.997305501 6797024.076853475 1.0 1.8623229577013674 0.7855170628090603 23.044757283714137 -6.693506031023679 1.854587834875505 1.5388425447196896 0.7891335295954628 0.38670100314745515 0.36444632590578196 0.4091189916225537 2.7310421768652486 0.15707216075767028 0.4071336775345231 2.0253214811012242e-07 6.693506031023679 -0.7497090151242268 SAYALCTFALSTGDPSQPVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAYALCTFALSTGDPSQPVR 20 0 Q9BY32;Q9BY32-3;Q9BY32-2 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 0 8767400.0 1813600.0 2253100.0 4700700.0 False True 2484136.9306971603 2153550.5919946595 3590491.4739553994 1.0 0.8669210482653533 1.4453677772697282 21.244313269369275 -6.846168031352642 1.2533791706366952 0.9291507919958019 1.4668451014860167 0.9345483280949488 0.06328227691164882 0.16172462979487254 0.49082603436053446 0.03954301852359038 0.091311878839774 1.425056123465806e-07 6.846168031352642 0.5376943094902148 SAYALCTFALSTGDPSQPVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SAYALCTFALSTGDPSQPVR 20 0 Q9BY32;Q9BY32-3;Q9BY32-2 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 0 9916100.0 4725400.0 2497000.0 2693700.0 False True 3929379.470714408 2483548.165384306 3256940.2157384106 1.0 0.6320458952600899 0.8288688430354781 21.905870068778224 -10.05143517245561 4.9649139989660185 1.000005261198308 0.7304573691457098 0.7143337314692166 0.08035263196054435 4.679618512494339e-06 8.938877963090276e-07 0.07780261979831177 0.025933700449566815 8.883105653738863e-11 10.05143517245561 -0.2695478920525981 SAYALCTFALSTGDPSQPVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SAYALCTFALSTGDPSQPVR 20 0 Q9BY32;Q9BY32-3;Q9BY32-2 Q9BY32 ITPA Inosine triphosphate pyrophosphatase 0 27233800.0 5703700.0 12326000.0 9204100.0 False True 7383552.086735589 11640047.264575196 7529048.242041171 1.0 1.576483395503679 1.0197054417164555 22.815883605806587 -10.331291042457556 3.3598452989119907 0.9983155522906858 1.298094418516315 0.27651185625331265 0.22730364961441046 54375247.76850255 69682687.0131075 890493.9412813232 0.08318461705962672 4.663467532844853e-11 10.331291042457556 0.2997788662256292 SAYDSTMETMNYAQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SAYDSTMETMNYAQIR 16 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 13952900.0 2389500.0 5058300.0 6505100.0 False True 3132657.6399509143 4303621.357098967 5832014.6533253705 1.0 1.3737924317725319 1.861682738308024 21.578955679239424 -6.967465185862503 0.3128667007634802 0.9273361179933154 2.3237123077412867 0.9999553171266539 0.0023583399693131286 0.07713408404830817 0.011959957144087908 0.0076214850454349135 0.043196729890018735 1.0777916487196122e-07 6.967465185862503 1.3963761897479712 SAYDSTMETMNYAQIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SAYDSTMETMNYAQIR 16 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 12096980.0 2945600.0 937480.0 8213900.0 False True 2852093.5403399216 1311820.6528936147 6062433.178281954 1.0 0.45995008029689927 2.125608116471318 21.443589868066535 -6.819431661797586 1.3745355506206043 0.7087567351558647 2.1614689045962994 0.8830271839669932 0.2373114985437296 0.19422228773253902 0.7212296135150348 0.13568382864108844 0.31274656047980176 1.5155432625288717e-07 6.819431661797586 1.4527121694404346 up SAYDSTMETMNYAQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SAYDSTMETMNYAQIR 16 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 11593900.0 2389500.0 4323900.0 4880500.0 False True 3272962.723809471 4132855.8007748052 3727826.4170526294 1.0 1.2627262054376491 1.1389761300775625 21.642165740762316 -10.239102928335043 4.433961628363772 0.999915065211723 1.2008511677604614 0.7783854777467315 0.05052075672020985 4.243586662647936e-05 7.282189285697075e-06 0.04893716003837089 0.016305504116575345 5.7662978521660514e-11 10.239102928335043 0.2009361025487384 SCAHDWVYE ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCAHDWVYE 9 0 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 43570400.0 9179400.0 15265000.0 19126000.0 False True 12034282.293436056 12987521.502503945 17147024.989546817 1.0 1.0792103081700037 1.424848160567036 23.520646768418978 -6.942881907790295 0.6321888631974202 0.9962288979692903 1.5265274348647362 0.9985174849614016 0.007102415991497194 0.08647623235444966 0.04880560557912166 0.007075167110506217 0.029391579725051492 1.1405598834333563e-07 6.942881907790295 0.5302985368954459 SCAHDWVYE ddPTM_RPMI8226_Bortezomib_2h_R1 1 SCAHDWVYE 9 0 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 19446200.0 12117000.0 3153400.0 4175800.0 False True 11732352.46751046 4412569.064763758 3082032.708685245 1.0 0.37610266798437575 0.2626952026219883 23.483988983028233 -13.999999999999996 0.23979654640620252 5.125536287247646 0.21245547041896157 0.9995246251554235 0.0070677260422469445 13.616288439197012 0.15498944400871556 26.896399925959827 0.05548168045297836 1.0000000000000082e-14 13.999999999999996 -4.913080816828685 SCAHDWVYE ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCAHDWVYE 9 0 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 160757000.0 25625000.0 122230000.0 12902000.0 False True 38874998.43843712 100417101.51265098 10351914.044852516 1.0 2.5830766700009677 0.26628718869907925 25.212339281503418 -6.722752452297883 1.749301723648214 1.9602791790614262 0.2693017618153519 0.525509617872967 0.6659499045150158 0.3500042273655484 2.0945622317332573 0.3020987774268344 0.7559682266565553 1.8934225613120782e-07 6.722752452297883 -1.6909774172460743 SCAHDWVYE ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCAHDWVYE 9 0 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 38907400.0 9179400.0 14000000.0 15728000.0 False True 12573272.243957603 13381433.708191045 12013370.328327794 1.0 1.0642761445511388 0.9554688783662595 23.58385682994187 -6.746626932422416 1.6621752475484655 1.0379473925837304 0.9553050740794334 0.6343915985321427 0.02700604325230943 0.3059666653266876 1.6620764389162865 0.012840263507500664 0.03128576384513358 1.7921446808413426e-07 6.746626932422416 -0.08264231850429693 SCAHDWVYE ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SCAHDWVYE 9 0 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 16541600.0 12117000.0 1659200.0 2765400.0 False True 10075822.374115724 1650261.5602745865 3343632.3542350736 1.0 0.16378430454610085 0.33184709198771656 23.26439425846251 -10.17901981053682 7.750673500992056 1.0000003259679031 0.2478156993305871 0.9639095623041243 0.06861134566363121 3.86477278867207e-07 4.087074937605896e-08 0.06643267848454627 0.022144216593010354 6.621862970890389e-11 10.17901981053682 -0.752184626637316 SCAHDWVYE ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCAHDWVYE 9 0 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 61068000.0 25625000.0 15562000.0 19881000.0 False True 33172067.644265953 14695961.01990259 16262861.996286495 1.0 0.4430221588084486 0.4902577123225436 24.983465603595867 -10.084291447941036 7.820913034090346 1.000000036757057 0.4666399369647272 0.9941519496994433 0.019283833971243648 1.2360379672131201e-08 1.4585643279249583e-09 0.018671493068313318 0.00622383065180464 8.235852349054736e-11 10.084291447941036 -0.5333600997923298 SCATFSSSHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCATFSSSHR 10 0 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-5;D6RCQ9;D6RE64;D6RHE8;D6RBT0 D6REX3 SEC31A Protein transport protein Sec31A 0 7403300.0 1692500.0 2844800.0 2866000.0 False True 2218883.8901933134 2420366.9289435507 2569453.812613259 1.0 1.090803777358843 1.1579938111991084 21.081402745455318 -6.974426734308834 0.10912810932529965 0.8568327136312999 1.3936787585626256 0.9999996235829294 3.92982276884765e-05 0.07489037778512962 0.0032234420649084354 0.0053933215963969956 0.0103444299692171 1.0606528559348875e-07 6.974426734308834 0.5368460449313257 SCATFSSSHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SCATFSSSHR 10 0 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-5;D6RCQ9;D6RE64;D6RHE8;D6RBT0 D6REX3 SEC31A Protein transport protein Sec31A 0 1959410.0 933150.0 239950.0 786310.0 False True 903527.6640304849 335763.2863227192 580351.822205636 1.0 0.3716137310339073 0.6423177123507035 19.785209248353024 -10.39759862384979 5.98570031043096 1.0001222033215769 0.5069657216923504 0.8155956290528967 0.11051443759434444 0.00018027069416426427 1.8142566163614654e-05 0.10703136081433735 0.03566838135986444 4.003145506539152e-11 10.39759862384979 -0.49315648162922643 SCATFSSSHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCATFSSSHR 10 0 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-5;D6RCQ9;D6RE64;D6RHE8;D6RBT0 D6REX3 SEC31A Protein transport protein Sec31A 0 5168500.0 1692500.0 1651900.0 1824100.0 False True 2318262.98809271 1578913.595897197 1393285.1485187376 1.0 0.6810761350230617 0.6010039221930669 21.14461280697821 -13.999999999999998 0.19407621497867986 2.734390449832828 0.5458571982820709 0.9994876786886551 0.003900917079426042 12.419954061628765 0.1397043146323405 8.157820614380503 0.0533332380316109 1.0000000000000041e-14 13.999999999999998 -2.188533251550757 SCDLLLFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCDLLLFLR 9 0 Q6PJG6;Q6PJG6-3 Q6PJG6 BRAT1 BRCA1-associated ATM activator 1 0 1819320.0 397280.0 810240.0 611800.0 False True 520837.9272649923 689355.350290784 548496.8047999967 1.0 1.3235505983803928 1.0531045764663218 18.990474983395075 -10.235229865109035 4.378059411052296 0.9999155317801895 1.1883275874270094 0.3926713385176659 0.11040912612176301 9.107262364431544e-05 1.5908553832878495e-05 0.10695104589216296 0.03563439222648349 5.817952013880614e-11 10.235229865109035 0.18841205564681984 SCDLLLFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCDLLLFLR 9 0 Q6PJG6;Q6PJG6-3 Q6PJG6 BRAT1 BRCA1-associated ATM activator 1 0 1200570.0 397280.0 803290.0 0.0 False True 544165.1520883141 767797.9916751975 0.0 1.0 1.4109650144421402 0.0 19.053685044917966 -6.855362104482045 1.3939562325872021 1.2177539986421475 2.6540817778565317e-21 0.9024910450528865 0.18502265928062095 0.16963073301968393 0.6625252625489815 0.10688401722280846 0.22430118703298663 1.395204587326216e-07 6.855362104482045 -1.2177539986421475 down SCEK(ub)IHFIAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCEKIHFIAPK 11 1 P40306 P40306 PSMB10 Proteasome subunit beta type-10 1 3819750.0 504030.0 768120.0 2547600.0 True False 660788.2110334629 653519.4901083099 2283998.790304791 1.0 0.9889999234190561 3.456476299316314 19.333828422641997 -6.905896363214345 0.9232329432852463 0.9133374534190309 3.74887134861779 0.9892784789958062 0.12017359925232729 0.10719451540192983 0.15395215647192897 0.09643350399143438 0.2592052451169149 1.241948641564778e-07 6.905896363214345 2.835533895198759 up SCEK(ub)IHFIAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCEKIHFIAPK 11 1 P40306 P40306 PSMB10 Proteasome subunit beta type-10 1 125877900.0 2357300.0 9530600.0 113990000.0 True False 3576196.441714254 7829789.967082325 91459826.53640825 1.0 2.189418309283118 25.574609232754245 21.769994555762366 -6.917456644253435 0.8433846176209352 0.43522305937687733 29.133452086043988 0.9934445670605281 0.9160983596857175 0.09969134471888395 0.11354259981587929 0.7788612901688662 2.2792002746464304 1.2093259042799504e-07 6.917456644253435 28.69822902666711 up SCEK(ub)IHFIAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCEKIHFIAPK 11 1 P40306 P40306 PSMB10 Proteasome subunit beta type-10 1 3864890.0 504030.0 553960.0 2806900.0 True False 690383.5118985929 529484.2154992505 2143968.0299200956 1.0 0.7669421508099744 3.10547397637592 19.397038484164888 -6.8823787050318685 1.0664140522734527 0.8504485649256851 3.2789740943679235 0.9755552901595299 0.16444289329870065 0.1255452074305793 0.2597144637785481 0.11851683378339861 0.2884245898859552 1.311056158714652e-07 6.8823787050318685 2.4285255294422385 up SCEK(ub)IHFIAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SCEKIHFIAPK 11 1 P40306 P40306 PSMB10 Proteasome subunit beta type-10 1 7433220.0 739640.0 823980.0 5869600.0 True False 615043.4316077373 819541.0561927748 7096906.222035939 1.0 1.3324929819191405 11.538870033103949 19.230328765137006 -6.913831605694248 0.8692253541951832 0.720982527639806 12.972017392682067 0.9922891551172668 0.4295370394335115 0.10193876595936346 0.1254234842164687 0.3584705159257618 1.0179052693084392 1.2194623443016277e-07 6.913831605694248 12.25103486504226 up SCEK(ub)IHFIAPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCEKIHFIAPK 11 1 P40306 P40306 PSMB10 Proteasome subunit beta type-10 1 84417100.0 2357300.0 5818800.0 76241000.0 True False 3051571.3193298765 5494978.6648637075 62365920.298721425 1.0 1.8007046501113406 20.43731368940017 21.541120877854816 -6.915915064698559 0.8544691645329111 0.5252078716980049 23.17738715344925 0.9929690407918764 0.7529854497137126 0.10063538109244148 0.11850792733539857 0.6351117810945806 1.8341302041226788 1.2136261770496973e-07 6.915915064698559 22.652179281751245 up SCENLAPFNTALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCENLAPFNTALK 13 0 A8MU58;Q13155-2;Q13155 A8MU58 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 0 9302240.0 636040.0 4770900.0 3895300.0 False True 833854.5994201213 4059100.316822543 3492251.7223560433 1.0 4.867875430135326 4.188082340475933 19.669436314961278 -10.23286849444747 7.22619918463805 0.9999899126330235 4.527978885305628 0.9729083940262434 0.27752436672259473 4.51327603033503e-05 4.791981083211236e-06 0.2687125737479063 0.08957060420694746 5.849671869877143e-11 10.23286849444747 3.5279889726726044 SCENLAPFNTALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCENLAPFNTALK 13 0 A8MU58;Q13155-2;Q13155 A8MU58 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 0 8891540.0 636040.0 4369900.0 3885600.0 False True 871201.1763347044 4176823.368673139 2967901.3064439544 1.0 4.794327053420387 3.4066773405086916 19.73264637648417 -9.61046492108099 11.030341856122764 0.9999999999999996 4.100502196964762 0.8693912843006926 0.5665056230588701 0.0 0.0 0.548516710909965 0.18283890363665495 2.4520825058996097e-10 9.61046492108099 3.100502196964763 SCFLCMVCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCFLCMVCK 9 0 P21291;E9PS42 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 29486500.0 11321000.0 9141100.0 9024400.0 False True 14841940.632719958 7777283.511728716 8090641.656157391 1.0 0.5240071837090645 0.5451202006778737 23.823176405641654 -10.18424266028981 4.799763808893742 1.0000565480590433 0.5345636921916572 0.998459109355228 0.008619353090288053 5.216350669537301e-06 8.865562305886095e-07 0.008346663365682743 0.002781884246927525 6.542705009145449e-11 10.18424266028981 -0.4654928558673861 SCFLCMVCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCFLCMVCK 9 0 P21291;E9PS42 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 21871100.0 11321000.0 4430600.0 6119500.0 False True 15506679.638521474 4234841.44196508 4674200.135058617 1.0 0.27309788689030157 0.3014313988564667 23.886386467164545 -10.627976445556703 6.524409209840278 1.0026649827268654 0.2872646428733876 0.9988161650840278 0.011567107823024319 0.00044935084837091855 2.5622079422272368e-05 0.011223641056623738 0.003733267996863226 2.3551770160718656e-11 10.627976445556703 -0.7154003398534778 SCFVK(ub)EALHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCFVKEALHR 10 1 Q6WRX3-2;Q6WRX3 Q6WRX3-2 ZYG11A Protein zyg-11 homolog A 1 5658400.0 1182800.0 2115100.0 2360500.0 True False 1550662.2542514948 1799535.3245952267 2116258.1035148622 1.0 1.1604946980952102 1.3647447067939245 20.564453060225922 -6.967844889208405 0.3053097693402074 0.9667388806063343 1.5649492509913672 0.999960353453848 0.0009398250259299444 0.07700841535058889 0.011520231492898938 0.003302502388528858 0.018217873568865842 1.0768497480858689e-07 6.967844889208405 0.5982103703850329 SCFVK(ub)EALHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCFVKEALHR 10 1 Q6WRX3-2;Q6WRX3 Q6WRX3-2 ZYG11A Protein zyg-11 homolog A 1 25056600.0 4021600.0 8007000.0 13028000.0 True False 6101061.218342183 6578088.29102346 10453010.089624744 1.0 1.0781875571494262 1.7133101464707312 22.540628776143887 -6.9298120185720915 0.7483282704407311 0.9902745904588044 1.8430779730091384 0.9965013376627361 0.018893973428777727 0.09273514240836501 0.07815746465648205 0.017194243026696535 0.057526941083911376 1.1754062114727588e-07 6.9298120185720915 0.852803382550334 SCGK(ub)DGFHIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCGKDGFHIR 10 1 F8W7C6;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 15503000.0 2614100.0 2582900.0 10306000.0 True False 3427110.4149804143 2197541.388065344 9239633.982132664 1.0 0.6412228151329938 2.696042106418526 21.70856124282076 -6.861840609197384 1.1763002377095828 0.8042882999983539 2.799149577381996 0.9558447823763625 0.18830665952801542 0.14492337511712947 0.37998541833165705 0.12475470649780825 0.2918645707779989 1.374546355926235e-07 6.861840609197384 1.994861277383642 up SCGK(ub)DGFHIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SCGKDGFHIR 10 1 F8W7C6;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 16951500.0 2686200.0 3607300.0 10658000.0 True False 2600928.0513515375 5047713.701820994 7866350.066853619 1.0 1.9407356151962822 3.024439704422418 21.310595060341328 -6.969272917638988 0.27499746981681616 0.7464080684163976 4.251566268843313 0.9999761432649155 0.004040126646780962 0.07653932521508953 0.0098715084064102 0.020612090902331296 0.10011434793212293 1.073314712135537e-07 6.969272917638988 3.5051582004269157 SCGK(ub)DGFHIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCGKDGFHIR 10 1 F8W7C6;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 14773700.0 4121700.0 10652000.0 0.0 True False 6252920.236632441 8751067.375544142 0.0 1.0 1.3995168728167078 0.0 22.576098683414934 -6.857891487693006 1.3882682402961606 1.2112878970798413 2.747950433713977e-22 0.9057862038680271 0.180672578487479 0.16733523007159634 0.6483070814589308 0.10487403822994393 0.21939995903465057 1.3871023653383914e-07 6.857891487693006 -1.2112878970798413 down SCGK(ub)DGFHIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCGKDGFHIR 10 1 F8W7C6;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 21307800.0 2614100.0 3092700.0 15601000.0 True False 3580603.413396256 2956054.2878087433 11916365.112680677 1.0 0.825574336646482 3.328032662901873 21.771771304343652 -6.890181322689172 1.021284997437445 0.8661242674742098 3.5440532230101955 0.9810149568993687 0.15718408207053322 0.11899711780332836 0.22097736076431654 0.11723967054267176 0.29247869561808887 1.2877118057014108e-07 6.890181322689172 2.677928955535986 up SCGK(ub)DGFHIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SCGKDGFHIR 10 1 F8W7C6;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 20690200.0 2686200.0 2851000.0 15153000.0 True False 2233694.3188371416 2835641.0971208066 18321422.240444057 1.0 1.2694848499220956 8.20229611811081 21.091000335775604 -6.915101283971634 0.8602587118610028 0.8184018325096561 9.20338779739066 0.9927087143095028 0.28464369525521255 0.10114088026430307 0.12117957287411031 0.23908705214974904 0.6858343567183702 1.215902400944063e-07 6.915101283971634 8.384985964881004 up SCGK(ub)DGFHIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCGKDGFHIR 10 1 F8W7C6;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 49932700.0 4121700.0 11723000.0 34088000.0 True False 5335621.900853503 11070604.74465479 27884333.772416588 1.0 2.0748480590208054 5.226070042173738 22.347225005507383 -6.951966621083 0.5368195614077207 0.952610251088854 6.493040692583836 0.9993467158704313 0.04583717256263217 0.08270553321121941 0.03276756737714088 0.05063882635015448 0.2608374733923928 1.116949090727814e-07 6.951966621083 5.5404304414949825 SCGLHVTSIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCGLHVTSIK 10 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9 A0A3B3IRI2 CTPS1 CTP synthase 1 0 11456000.0 1491100.0 5221300.0 4743600.0 False True 1954846.5398329385 4442302.392467994 4252777.775824231 1.0 2.2724558178605845 2.175504669633901 20.898623926262513 -10.12537183221746 4.6874874123598325 0.9999027331709123 2.2239802437631377 0.9953164028484757 0.03958014057651247 13810204.29045642 2.820832175281027 14498.485815400383 0.013549334881188443 7.492524431884202e-11 10.12537183221746 1.2240775105922255 SCGLHVTSIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SCGLHVTSIK 10 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9 A0A3B3IRI2 CTPS1 CTP synthase 1 0 5147890.0 3344800.0 605690.0 1197400.0 False True 3238621.1548509505 847545.1756316242 883765.018769988 1.0 0.2616993884456456 0.2728831118287008 21.626948284760765 -10.044372021708494 5.18614395443951 1.0000081078763237 0.2672912501350313 0.999825298691169 0.004565735959625276 4.2802952670990634e-07 7.886843974342886e-08 0.004420803732467455 0.0014735849434923968 9.028757285112977e-11 10.044372021708494 -0.7327168577412924 SCGLHVTSIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCGLHVTSIK 10 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9 A0A3B3IRI2 CTPS1 CTP synthase 1 0 25821300.0 4837700.0 15895500.0 5088100.0 False True 7339144.583243987 13058823.83289165 4082434.804806544 1.0 1.7793386797020287 0.5562548548405979 22.807180488328655 -6.734557486033747 1.7064998982973696 1.46660414992746 0.556340268709805 0.5803009242629915 0.3275154095108716 0.32776450991221334 1.871890577781235 0.15196271375994685 0.3751715004356081 1.8426485679145752e-07 6.734557486033747 -0.910263881217655 SCGLHVTSIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCGLHVTSIK 10 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9 A0A3B3IRI2 CTPS1 CTP synthase 1 0 12070700.0 1491100.0 4693800.0 5885800.0 False True 2042399.965462356 4486412.395679074 4495695.2618560335 1.0 2.196637520341637 2.201182597865107 20.961833987785404 SCGLHVTSIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SCGLHVTSIK 10 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9 A0A3B3IRI2 CTPS1 CTP synthase 1 0 5876030.0 3344800.0 531160.0 2000070.0 False True 2781349.3997641546 528298.5356529948 2418275.3897211715 1.0 0.18994324686348002 0.869461201072483 21.40735356019504 -10.701780193896106 9.336744936808735 1.0007726283868246 0.5297022239711074 0.38975239789313687 0.277412043145327 0.004467726281552136 0.0001427012601758424 0.26897008361813407 0.08953435192826877 1.9871003786235966e-11 10.701780193896106 -0.4710704044157171 SCGLHVTSIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCGLHVTSIK 10 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9 A0A3B3IRI2 CTPS1 CTP synthase 1 0 9654800.0 4837700.0 1631500.0 3185600.0 False True 6262498.015323524 1540705.5907962364 2605853.4870162625 1.0 0.24602093078933177 0.41610448109365866 22.578306810421104 -10.518472366146305 9.30742242288085 1.0000220599392675 0.33106270597662973 0.9537563083046275 0.06943631864776591 3.17860260658271e-05 1.6443763028040057e-06 0.06723362843842769 0.022410475478729073 3.03059312617146e-11 10.518472366146305 -0.6689593539626377 SCGSSTPDEFPTDIPGTK(ub)GNFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCGSSTPDEFPTDIPGTKGNFK 22 1 P41091;H7BZU1 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 44680800.0 8999800.0 15515000.0 20166000.0 True False 11798824.95418717 13200222.476996338 18079415.765931252 1.0 1.1187743294989592 1.5323064657820205 23.492139852851334 -6.948065463077376 0.5797025313466392 0.9950513608212347 1.676472597953043 0.9990405192641487 0.007067013603176731 0.08427216577570652 0.039251384355500976 0.00740677234170653 0.0345418360345656 1.1270275616538954e-07 6.948065463077376 0.6814212371318084 SCGSSTPDEFPTDIPGTK(ub)GNFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SCGSSTPDEFPTDIPGTKGNFK 22 1 P41091;H7BZU1 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 37805250.0 12035250.0 13191000.0 12579000.0 True False 11653197.57651277 18458235.09015625 9284182.538088933 1.0 1.5839631113231234 0.7967068675469272 23.474222541392454 -6.708063519721593 1.8023336837954111 1.3597181925588422 0.7986771826214889 0.4558214038364867 0.2461545735200829 0.37896847992727223 2.3985376018167925 0.1087411469759119 0.2768808958353221 1.958558194688643e-07 6.708063519721593 -0.5610410099373533 SCGSSTPDEFPTDIPGTK(ub)GNFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCGSSTPDEFPTDIPGTKGNFK 22 1 P41091;H7BZU1 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 208495400.0 28932000.0 37240000.0 142323400.0 True False 43891959.2125214 30594231.04255197 114193117.6074379 1.0 0.6970349829775682 2.6016864969395384 25.387453333659565 -6.8661839986981645 1.1540185614862286 0.8320186704762071 2.7054658679525416 0.9607279493698591 0.16560337986000961 0.14057024715097743 0.3522742737493008 0.11160295360263019 0.262623952307803 1.360867997747935e-07 6.8661839986981645 1.8734471974763345 up SCGSSTPDEFPTDIPGTK(ub)GNFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCGSSTPDEFPTDIPGTKGNFK 22 1 P41091;H7BZU1 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 48845800.0 8999800.0 21709000.0 18137000.0 True False 12327269.270450087 20749824.597937096 13853414.143240165 1.0 1.6832458302567352 1.1238023474062033 23.555349914374226 -10.384128536696686 3.7972079804680305 0.9981521092213463 1.4035240888678124 0.4095730658379837 0.2283918456360855 29754021.020625867 27129648.92961461 410203.1967451107 0.07818460233444681 4.129252717805434e-11 10.384128536696686 0.4053719796464661 SCGSSTPDEFPTDIPGTK(ub)GNFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SCGSSTPDEFPTDIPGTKGNFK 22 1 P41091;H7BZU1 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 43580950.0 12035250.0 7573700.0 23972000.0 True False 10007843.626976665 7532898.974838263 28984434.365995172 1.0 0.7526995080671466 2.896171787483381 23.25462781682673 -6.878180378409383 1.0899415913886208 0.8501361141318562 3.0428494240139976 0.9721858326099169 0.15968630066461043 0.12925202413054845 0.2821546827621949 0.11304115385119773 0.27213283973670527 1.3237916018474402e-07 6.878180378409383 2.1927133098821416 up SCGSSTPDEFPTDIPGTK(ub)GNFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCGSSTPDEFPTDIPGTKGNFK 22 1 P41091;H7BZU1 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 1 176574000.0 28932000.0 38592000.0 109050000.0 True False 37453044.33498149 36444321.27490554 89204018.94748978 1.0 0.9730669942060278 2.3817561571135726 25.158579655752014 -6.902542160188883 0.9450523816295328 0.945446707590053 2.537501411660105 0.9877892890347348 0.07268895366962692 0.10955830566466482 0.1670524610330753 0.05739902871925958 0.15134110526547576 1.2515777671904619e-07 6.902542160188883 1.592054704070052 up SCGVPEESASSEKAK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 SCGVPEESASSEKAK 15 1 Q58WW2;Q58WW2-2;Q58WW2-4;Q58WW2-3 Q58WW2 DCAF6 DDB1- and CUL4-associated factor 6 1 2828820.0 1377400.0 1101200.0 350220.0 True False 1333675.1909506419 1540914.9026821386 258486.87562520907 1.0 1.1553899428719046 0.1938154637494306 20.34697591840844 -6.865487689672752 1.1577643797786656 1.0858817572859039 0.14214188923197008 0.9599648652695362 0.08433028358870821 0.1412511698006289 0.35672213723376356 0.0566722964396478 0.1332128415070791 1.3630516421441762e-07 6.865487689672752 -0.9437398680539337 down SCGVPEESASSEKAK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SCGVPEESASSEKAK 15 1 Q58WW2;Q58WW2-2;Q58WW2-4;Q58WW2-3 Q58WW2 DCAF6 DDB1- and CUL4-associated factor 6 1 2735660.0 1377400.0 785070.0 573190.0 True False 1145369.129166214 780840.6720858054 693041.37886888 1.0 0.6817371380126408 0.6050812451819687 20.127381193842716 -13.999999999999991 0.19995909618532637 2.768904072663526 0.5552773449221051 0.9994869270506155 0.0038730358582884936 12.530060731292778 0.14178955932045909 8.668508768733194 0.04882522061657302 1.0000000000000205e-14 13.999999999999991 -2.2136267277414206 SCGYSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCGYSVR 7 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 6077570.0 919270.0 3071700.0 2086600.0 False True 1205171.872223343 2613414.333392823 1870698.6480805401 1.0 2.1684992768471316 1.5522256129571048 20.200807476378944 -10.21972942643931 5.728037035628641 0.999970808077242 1.8603624449021372 0.7221210745166947 0.25159266974107247 9.379575669425742e-05 1.2776357782560315e-05 0.2436117803210921 0.0812011849945765 6.029351088993686e-11 10.21972942643931 0.8603916368248952 SCGYSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCGYSVR 7 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 3973070.0 919270.0 1612500.0 1441300.0 False True 1259148.9613376579 1541254.4181755746 1100894.6245052677 1.0 1.2240445455621245 0.8743164298334738 20.264017537901836 -6.733675264486024 1.7095975938670858 1.134276395917588 0.8743732288595157 0.5762431709910284 0.09415960990402363 0.3294298548129709 1.8878370694127808 0.043614946086196545 0.10778972976504876 1.8463955105917238e-07 6.733675264486024 -0.25990316705807237 SCIEAHEK(ub)DMELSFAVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SCIEAHEKDMELSFAVQR 18 1 Q9UHC7-2;Q9UHC7;Q9UHC7-3;Q9UHC7-4 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 10412400.0 1774800.0 3025300.0 5612300.0 True False 1718459.9454764018 4233318.066731081 4142270.2646089895 1.0 2.4634371478222006 2.410454939908794 20.71268479453685 -9.897810283432902 5.9545117202814195 0.9999996069622351 2.4369460438663233 0.998981413571015 0.021629895808585684 1.1284517178948358e-07 2.0859184728138328e-08 0.020943062177162765 0.006981018853474823 1.265288953740843e-10 9.897810283432902 1.4369464369040883 SCIEAHEK(ub)DMELSFAVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCIEAHEKDMELSFAVQR 18 1 Q9UHC7-2;Q9UHC7;Q9UHC7-3;Q9UHC7-4 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 158254700.0 10569700.0 87663000.0 60022000.0 True False 16035007.64857555 72018852.7358548 48158625.39142286 1.0 4.491351317955406 3.003342838798145 23.93472170614572 -9.305498499710003 9.99899942561976 0.999995143548771 3.7473470783800087 0.8196645283950504 0.6074769178182544 0.0 0.0 0.5881869964759092 0.19606233215863636 4.948818205090406e-10 9.305498499710003 2.747351934831238 SCIEAHEK(ub)DMELSFAVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SCIEAHEKDMELSFAVQR 18 1 Q9UHC7-2;Q9UHC7;Q9UHC7-3;Q9UHC7-4 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 11767900.0 1774800.0 1747300.0 8245800.0 True False 1475824.8369712457 1737886.9480881055 9969958.655728469 1.0 1.177569928728585 6.755516241472984 20.493090069971128 -6.9136816188976375 0.8702941987402328 0.8467498941168845 7.536142416513288 0.9922382098252354 0.23543290783303936 0.1020333281210412 0.12593606210589106 0.19633207605671793 0.556835206491723 1.2198835673319899e-07 6.9136816188976375 6.689392522396403 up SCIEAHEK(ub)DMELSFAVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCIEAHEKDMELSFAVQR 18 1 Q9UHC7-2;Q9UHC7;Q9UHC7-3;Q9UHC7-4 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 120950700.0 10569700.0 88852000.0 21529000.0 True False 13682685.009935513 83907308.09281473 17610942.906194493 1.0 6.132371536133914 1.2870970056978235 23.70584802823817 -6.632618478526258 2.070941289637835 4.374794721142418 1.3067681177909019 0.1270162591670999 2.2000553547026063 0.5522061195930229 4.516608862543849 0.8678608847889436 2.436874635744357 2.330137351045864e-07 6.632618478526258 -3.0680266033515164 SCIEQDVVNQTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCIEQDVVNQTR 12 0 Q8WW33;G3V1V4 Q8WW33 GTSF1 Gametocyte-specific factor 1 0 8827900.0 2652600.0 3119400.0 3055900.0 False True 3477584.287814941 2653997.6793259624 2739704.782262688 1.0 0.7631727830796993 0.787818369165717 21.72965405178082 -9.902110169641007 5.3471994530720055 1.000000302405031 0.7754955762438785 0.9910425947700581 0.010061518393279541 3.6276897940451825e-08 7.438658501191776e-09 0.00974203635594804 0.0032473410970009524 1.2528233247046216e-10 9.902110169641007 -0.22450472616115247 SCIEQDVVNQTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCIEQDVVNQTR 12 0 Q8WW33;G3V1V4 Q8WW33 GTSF1 Gametocyte-specific factor 1 0 10120700.0 2652600.0 3336800.0 4131300.0 False True 3633337.9038196313 3189369.142677988 3155572.02679429 1.0 0.8778069166991292 0.8685049699002455 21.79286411330371 -13.999999999999998 0.36528662355736324 2.652466566393697 0.8674683664916468 0.9997827141816746 0.0008831700938346707 22.27902190462751 0.19576428205857424 28.768729503101568 0.0026387369519889885 1.0000000000000041e-14 13.999999999999998 -1.7849981999020499 SCIILEFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCIILEFK 8 0 Q9UKF6 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 28655000.0 8323700.0 10538000.0 9793300.0 False True 12627661.443981227 8657411.566230202 7857649.962444133 1.0 0.685591041907179 0.6222569394422082 23.590084150878074 -13.999999999999998 0.22524443847931894 2.9420814383950344 0.5900361129143208 0.9995036803859005 0.0036798698229245598 13.14766503080528 0.15030862510390178 11.389464288150785 0.033877085198768045 1.0000000000000041e-14 13.999999999999998 -2.352045325480714 SCIILEFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCIILEFK 8 0 Q9UKF6 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 9722200.0 2293200.0 3375000.0 4054000.0 False True 3141058.011399826 3225881.340367484 3096528.6947508208 1.0 1.0270046999004185 0.985823465696146 21.5828191573271 -6.729785033675667 1.7239083818039813 1.0162549720470904 0.9858484054001214 0.5583316366924937 0.011352311730445172 0.3366333067569221 1.9598120612072931 0.005218625671437952 0.012953344482007616 1.8630090574489382e-07 6.729785033675667 -0.030406566646968947 SCIILEFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCIILEFK 8 0 Q9UKF6 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 0 23902900.0 8323700.0 8789600.0 6789600.0 False True 10775193.734656641 8300451.033320632 5553962.46717906 1.0 0.7703296328328273 0.5154396852574122 23.361210472970523 -6.969781071084424 0.26336469455023076 1.0686839008998836 0.20948982229552146 0.999980622985898 0.0008711683535306469 0.0763738300367445 0.009284124691295373 0.0052074744236986865 0.023929956637132984 1.0720595969223028e-07 6.969781071084424 -0.8591940786043621 SCIK(ub)IPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCIKIPR 7 1 Q7Z3T8 Q7Z3T8 ZFYVE16 Zinc finger FYVE domain-containing protein 16 1 54025000.0 12543000.0 28196000.0 13286000.0 True False 16443994.46658478 23989266.707147185 11911292.168311149 1.0 1.4588466783964729 0.7243551554651539 23.971057455758253 -6.737802852250363 1.6949010453083333 1.2737059765320258 0.7241407257311099 0.5949796746652156 0.1927998501643516 0.3218008587347676 1.8142950885963693 0.09002469757660228 0.2214338687115194 1.8289302696528492e-07 6.737802852250363 -0.5495652508009159 SCIK(ub)IPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SCIKIPR 7 1 Q7Z3T8 Q7Z3T8 ZFYVE16 Zinc finger FYVE domain-containing protein 16 1 20581600.0 9275600.0 7667900.0 3638100.0 True False 8981151.155206738 10729732.457570259 2685172.46933948 1.0 1.19469456332998 0.2989786523949969 23.098468942962036 -6.849785692433645 1.2361696357516192 1.1038753006517232 0.263328293599938 0.939986068662032 0.09423209234684987 0.15769413166216023 0.46383189754648907 0.059653382611317474 0.13801896137583178 1.413234749395494e-07 6.849785692433645 -0.8405470070517853 down SCIK(ub)IPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCIKIPR 7 1 Q7Z3T8 Q7Z3T8 ZFYVE16 Zinc finger FYVE domain-containing protein 16 1 107106000.0 57614000.0 28510000.0 20982000.0 True False 87404650.14759463 23422167.75035327 16834898.50326272 1.0 0.26797393171646766 0.19260872819506408 26.381206700990155 -13.999999999999998 0.32125599707386737 8.562036738473374 0.17785525002885716 0.9996964161876357 0.00634475747350657 18.111377884967006 0.1808139245412802 92.11388053648523 0.024969251258912677 1.0000000000000041e-14 13.999999999999998 -8.384181488444517 SCIK(ub)IPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCIKIPR 7 1 Q7Z3T8 Q7Z3T8 ZFYVE16 Zinc finger FYVE domain-containing protein 16 1 43595000.0 12543000.0 15079000.0 15973000.0 True False 17180486.061829757 14412759.920415195 12200506.374261191 1.0 0.8389029197745647 0.7101374390895325 24.034267517281144 -6.973659477486469 0.14638910896654314 1.157479793622285 0.3881842197356593 0.9999986902982969 0.00013558385697729183 0.07513220614910435 0.0044592593120535325 0.006814803135149753 0.016306361138855224 1.0625283400844036e-07 6.973659477486469 -0.7692955738866256 SCIK(ub)IPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SCIKIPR 7 1 Q7Z3T8 Q7Z3T8 ZFYVE16 Zinc finger FYVE domain-containing protein 16 1 25017900.0 9275600.0 5301300.0 10441000.0 True False 7713072.378752814 5272740.844674337 12624164.826270478 1.0 0.6836109640561842 1.6367232415770194 22.878874218396312 -6.8172246960357405 1.3838218878591553 0.8289758615676973 1.6563212246758516 0.8778887196464215 0.13850720371639413 0.19710961990904938 0.7424181974772281 0.07866817964178066 0.18146687794029737 1.5232644406750898e-07 6.8172246960357405 0.8273453631081543 SCIK(ub)IPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCIKIPR 7 1 Q7Z3T8 Q7Z3T8 ZFYVE16 Zinc finger FYVE domain-containing protein 16 1 95679000.0 57614000.0 23561000.0 14504000.0 True False 74582458.74172625 22249809.638216462 11864420.823607447 1.0 0.2983249682779428 0.15907789879511874 26.152333023082605 -13.999999999999998 0.2273604523832816 5.376042385985119 0.08965173334993401 0.9995063049889945 0.00817692156002408 13.210417447659657 0.15099619766418212 26.05862597787516 0.07348737982419054 1.0000000000000041e-14 13.999999999999998 -5.286390652635186 SCISVLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCISVLKR 8 1 Q96LD4;Q96LD4-2 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 4191100.0 1211700.0 1905100.0 1074300.0 True False 1588550.4341194914 1620866.5060216356 963141.7414132663 1.0 1.0203431198708253 0.6063022745306293 20.59927946352984 -6.895349395054416 0.9902268717229924 1.019478901907455 0.5667267118506527 0.9841062584990369 0.024024836735844702 0.11490902828584211 0.1973651042662502 0.018344373512751935 0.04670601845967899 1.2724789447249122e-07 6.895349395054416 -0.45275219005680234 SCISVLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCISVLKR 8 1 Q96LD4;Q96LD4-2 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 3415300.0 1211700.0 1046400.0 1157200.0 True False 1659698.234961263 1000166.5880179348 883893.1932821042 1.0 0.6026195406788986 0.5325625915983059 20.66248952505273 -13.999999999999998 0.24413612889456948 3.6839879013847447 0.5027796913837899 0.9995320211571254 0.004452813826689097 13.773049130589733 0.1563655065582797 18.06586019154792 0.033419793920690895 1.0000000000000041e-14 13.999999999999998 -3.181208210000955 SCISVLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SCISVLKR 8 1 Q96LD4;Q96LD4-2 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 4052500.0 1080500.0 1562100.0 1409900.0 True False 898483.6242660768 1553684.657247427 1704703.5713589443 1.0 1.7292297992815937 1.8973117876816346 19.777132683897776 -11.066682886723662 0.27568396271566536 2.791212042518582e-13 1.9603681158518134 0.9992380392593786 0.010750842505190024 3.0432765448683186 0.14462029382198258 1.9805598064432 0.06751261854306288 8.57663865909956e-12 11.066682886723662 1.9603681158515343 SCISVLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCISVLKR 8 1 Q96LD4;Q96LD4-2 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 10471100.0 1729000.0 2156100.0 6586000.0 True False 2238224.5836853012 2036111.1396357764 5387415.578066645 1.0 0.9096992118115603 2.4070040233389407 21.093923373070616 -6.8925606081302675 1.0070869993233038 0.9244170175056674 2.542449733104596 0.9824881055446522 0.09071977276563573 0.11709112186513655 0.20989673218473948 0.06839483879935536 0.17216307907262896 1.2806763567925314e-07 6.8925606081302675 1.6180327155989287 up SCLLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCLLLR 6 0 E9PLD0;Q9H0U4;Q92928;E7END7;P62820-2;P62820;P62820-3 E9PLD0;E7END7 RAB1B;RAB1C;RAB1A Ras-related protein Rab-1B;Putative Ras-related protein Rab-1C;Ras-related protein Rab-1A 0 6518000.0 1417600.0 2220600.0 2879800.0 False True 1858487.328057926 1889295.1358310052 2581825.920992208 1.0 1.0165768188504534 1.3892082458749684 20.825697420660614 -6.91621572782143 0.8523263262292793 0.990604300861992 1.4443614129763718 0.9930634083073241 0.014966097595260195 0.1004498429341034 0.11753217639229525 0.012642780890120676 0.03660292438022584 1.212786271472484e-07 6.91621572782143 0.45375711211437975 SCLLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCLLLR 6 0 E9PLD0;Q9H0U4;Q92928;E7END7;P62820-2;P62820;P62820-3 E9PLD0;E7END7 RAB1B;RAB1C;RAB1A Ras-related protein Rab-1B;Putative Ras-related protein Rab-1C;Ras-related protein Rab-1A 0 4839300.0 1417600.0 1837400.0 1584300.0 False True 1941725.0291995413 1756217.592530728 1210120.9696827137 1.0 0.9044625609295014 0.6232195349418631 20.888907482183505 -6.951874951713056 0.5378650106504477 1.0041997739298543 0.5105418999976583 0.9993403323450117 0.004107549259770108 0.08274145711185257 0.03291310022123518 0.004531201591622455 0.02328314110410381 1.1171848773438045e-07 6.951874951713056 -0.49365787393219596 SCLPQIK(ub)LYGPTNFSPIINHVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCLPQIKLYGPTNFSPIINHVAR 23 1 O75131 O75131 CPNE3 Copine-3 1 46966800.0 11543000.0 7943800.0 27480000.0 True False 14942641.046546778 7501720.5468385825 22478921.968610913 1.0 0.5020344478242164 1.504347317089957 23.832931824923403 -6.771649078687166 1.5684420681978508 0.7149793272274755 1.5102992317967379 0.7367235189807504 0.20996004046143651 0.26377052821973945 1.280857385412184 0.10550808065932832 0.25074415409830025 1.6918074041765513e-07 6.771649078687166 0.7953199045692624 SCLTGFLQEYGLSVMVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCLTGFLQEYGLSVMVK 17 0 Q13564;Q13564-4;Q13564-3;Q13564-2;J3KTE3;J3QLH4 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 0 29655600.0 8147000.0 9393600.0 12115000.0 False True 12359594.625480862 7717238.687468203 9720464.93980687 1.0 0.624392540476865 0.7864711776037464 23.559128090188523 -10.12452037575531 4.840443410702439 1.0000170402538775 0.7054318590384904 0.8149558523862126 0.06616832653402129 92341387.11035097 2.478343062924128 17537.715107768858 0.02265117814596161 7.507228316978236e-11 10.12452037575531 -0.2945851812153871 SCLTGFLQEYGLSVMVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCLTGFLQEYGLSVMVK 17 0 Q13564;Q13564-4;Q13564-3;Q13564-2;J3KTE3;J3QLH4 Q13564 NAE1 NEDD8-activating enzyme E1 regulatory subunit 0 20555900.0 8147000.0 5885400.0 6523500.0 False True 10546452.10137891 5557872.316317614 5336289.936762492 1.0 0.5269897651733461 0.5059796304450851 23.330254412280972 SCNCLLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCNCLLLK 8 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 273617000.0 37757000.0 117180000.0 118680000.0 False True 49499792.63930812 99697200.76406237 106400132.05894679 1.0 2.014093301168542 2.149506621861154 25.56091914579028 -10.828232101166382 0.38210354206044145 1.868904690367372e-12 2.164623347970811 0.9993970937538834 0.012595124382684758 2.4984846693871363 0.18623948351276806 2.303236873678959 0.03635625485303826 1.485141721878212e-11 10.828232101166382 2.1646233479689423 SCNCLLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCNCLLLK 8 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 482960000.0 69207000.0 350390000.0 63363000.0 False True 104992078.7094211 287860166.89043427 50839275.27701052 1.0 2.7417322376016937 0.48422010404913185 26.645705244726233 -6.700665739665267 1.8285735677639543 2.08083468696522 0.4908656271584896 0.42073015681907133 0.7351161539653804 0.39412484220684546 2.5625270237192304 0.3206704541258628 0.8239788531414403 1.9922060761001871e-07 6.700665739665267 -1.5899690598067306 SCNCLLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCNCLLLK 8 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 241479000.0 37757000.0 90872000.0 112850000.0 False True 51716783.24455923 86856974.56648113 86197154.21870486 1.0 1.6794736469928988 1.666715306153019 25.62412920731317 -10.058581204949354 5.666570552085673 0.999996885160285 1.673094476573127 0.9997306102087766 0.005208570837630382 2.0497296078962432e-07 3.405673869579085e-08 0.005043200315464518 0.0016810590092205327 8.738135905082671e-11 10.058581204949354 0.6730975914128421 SCNCLLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCNCLLLK 8 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 155909000.0 69207000.0 75563000.0 11139000.0 False True 89589825.77392046 71357852.62478457 9111816.29579173 1.0 0.7964950484986522 0.10170592717509418 26.416831566818683 -7.152643037389392 0.6907907622014815 0.9984968232693808 4.73805253556748e-24 0.9970265737245749 0.02097051707706904 0.08265432702298306 0.06758673158203332 0.019549200829720927 0.054131686048839986 7.036504384426312e-08 7.152643037389392 -0.9984968232693808 down SCNCLLLK(ub)VNQIGSVTESLQACK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCNCLLLKVNQIGSVTESLQACK 23 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 12361900.0 5885200.0 3756800.0 2719900.0 True False 7715554.192357861 3196300.0838917056 2438470.8391230963 1.0 0.4142670771540419 0.3160461035369779 22.87933835565374 -13.999999999999998 0.2512466094836333 5.099229977010471 0.2770186799645207 0.9995450454842306 0.00644032869314226 14.047752390963161 0.1586095552343675 29.084139110077555 0.045016428271664626 1.0000000000000041e-14 13.999999999999998 -4.82221129704595 SCNCLLLK(ub)VNQIGSVTESLQACK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SCNCLLLKVNQIGSVTESLQACK 23 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 79128000.0 52933000.0 14511000.0 11684000.0 True False 51252670.889059246 20305317.973865338 8623609.887513388 1.0 0.39618067939947793 0.16825679009353334 25.611123852790545 -10.615830054704704 0.20835379480891278 1.831017746247386 5.301812410796987e-10 0.9993364758726877 0.00903949714913773 2.407287216113845 0.10841915215443551 1.147566810586553 0.13117135628625495 2.42197661348045e-11 10.615830054704704 -1.8310177457172048 SCNCLLLK(ub)VNQIGSVTESLQACK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCNCLLLKVNQIGSVTESLQACK 23 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 606069100.0 205199100.0 149240000.0 251630000.0 True False 311302036.76365674 122606955.98255783 201895220.20665312 1.0 0.39385208415980305 0.6485509131439887 28.21373977509396 -10.346825579202296 5.843416042576952 1.0000730100915967 0.5212014986519139 0.8249250243252678 0.10398036151594535 9.891638570990398e-05 1.1056961101437453e-05 0.1006938054123398 0.03355951737365635 4.499605311858688e-11 10.346825579202296 -0.47887151143968276 SCNCLLLK(ub)VNQIGSVTESLQACK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCNCLLLKVNQIGSVTESLQACK 23 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 443389100.0 205199100.0 137820000.0 100370000.0 True False 265634280.02897543 130150195.84648314 82103689.88316865 1.0 0.4899600903629093 0.3090854458777413 27.98486609718641 -13.9999999999993 0.14442228750726663 3.4475579081338474 0.09673602799886061 0.9995859069855458 0.00595298355084591 11.941119954276973 0.11936988812403673 8.21841885306434 0.19045777669850486 1.0000000000016115e-14 13.9999999999993 -3.350821880134987 SCPVVQSSQHLFLDLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCPVVQSSQHLFLDLPK 17 0 P56192;P56192-2 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 14129400.0 3995400.0 5837400.0 4296600.0 False True 5238008.091508636 4966482.674006989 3852029.0478974627 1.0 0.9481624669610919 0.7353995985882512 22.32058685764391 -6.944283098786437 0.6184363815205992 1.0023313373727925 0.6699891665357744 0.9986727685331871 0.004170947924948258 0.08586590748250898 0.04611208772131039 0.004206474299017887 0.017995628459420234 1.1368859548346708e-07 6.944283098786437 -0.332342170837018 SCPVVQSSQHLFLDLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SCPVVQSSQHLFLDLPK 17 0 P56192;P56192-2 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 8664000.0 4192500.0 2236000.0 2235500.0 False True 4059411.3823584733 3128846.460585956 1649955.4864375393 1.0 0.7707635826670345 0.40645190423615885 21.9528391200557 -6.964279431562637 0.3702179544570841 1.027946708220018 0.13658344640280842 0.9998975023241363 0.0024743023132632667 0.07820642521803606 0.01572784560011193 0.0048003142374350586 0.030937118203440972 1.0857268259606102e-07 6.964279431562637 -0.8913632618172096 down SCPVVQSSQHLFLDLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCPVVQSSQHLFLDLPK 17 0 P56192;P56192-2 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 34643600.0 5724100.0 19470000.0 9449500.0 False True 8683878.187764207 15995426.380195666 7581802.183137012 1.0 1.8419680739803106 0.8730894214776013 23.04990805815827 -6.676994668974113 1.9131969944439304 1.5341626563946547 0.8769101100187784 0.31024180745840435 0.357083857861355 0.4451769796391769 3.147967534537128 0.14993128893540136 0.3968710761626316 2.1038042641014025e-07 6.676994668974113 -0.6572525463758763 SCPVVQSSQHLFLDLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCPVVQSSQHLFLDLPK 17 0 P56192;P56192-2 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 12689400.0 3995400.0 3501300.0 5192700.0 False True 5472607.351625178 3346600.988749234 3966291.207013464 1.0 0.6115185639538725 0.7247534771219446 22.3837969191668 -10.425265601155944 8.792804748190129 1.0000029338152758 0.6681360205379095 0.9196944934395982 0.04622795972168941 2.6587359814481643e-06 1.7378641009376302e-07 0.044760424893753134 0.01492000984427086 3.7560762395479295e-11 10.425265601155944 -0.3318669132773663 SCPVVQSSQHLFLDLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCPVVQSSQHLFLDLPK 17 0 P56192;P56192-2 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 19932400.0 5724100.0 7262200.0 6946100.0 False True 7409960.288879713 6858052.186013147 5681981.073004664 1.0 0.925518075488903 0.7668031745772964 22.82103438025072 -6.95878592766647 0.45221889223040745 1.005003727468727 0.6810022147932951 0.9997224845259319 0.0016200640084156571 0.08013769070009166 0.022755488955833916 0.0021285201876603266 0.01312414286473146 1.0995476946661448e-07 6.95878592766647 -0.32400151267543176 SCQAMFQQINDSFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCQAMFQQINDSFR 14 0 Q6P2E9;Q6P2E9-2;I3L2F4 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 0 1061800.0 1061800.0 0.0 0.0 False True 1392030.0824858262 0.0 0.0 1.0 0.0 0.0 20.408758958229328 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 SCQAMFQQINDSFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCQAMFQQINDSFR 14 0 Q6P2E9;Q6P2E9-2;I3L2F4 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 0 3913400.0 1061800.0 1201300.0 1650300.0 False True 1454376.1540660795 1148222.5938321357 1260533.1289953825 1.0 0.7894949257948066 0.866717406959156 20.47196901975222 -10.849078647727767 10.074447671519238 1.0051857435044596 0.8281061671109661 0.868533589621897 0.031525945920723504 0.003728982645660787 5.586230720042684e-05 0.03099856762271489 0.010174955293699812 1.4155374127068296e-11 10.849078647727767 -0.17707957639349348 SCQFVAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCQFVAVR 8 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 13592700.0 2794000.0 5877500.0 4921200.0 False True 3662961.0571344853 5000599.910315554 4412001.431483727 1.0 1.3651796544698993 1.204490400707457 21.80457893240242 -10.369549765237226 5.653003153148124 0.9999222579066679 1.2848350275886795 0.807299505260477 0.06560111314443563 6.429338653842497e-05 7.1703173464432115e-06 0.06353527501400472 0.021172668225088287 4.270219847458389e-11 10.369549765237226 0.2849127696820116 SCQFVAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCQFVAVR 8 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 8973100.0 2794000.0 0.0 6179100.0 False True 3827017.305010948 0.0 4719723.842559142 1.0 0.0 1.233264306482053 21.867788993925313 -6.691038424700459 1.86291558684952 0.37365784659998696 1.229030403480788 0.3751654563516418 0.42284349223275874 0.4144624018349467 2.7896039947533873 0.18153362276335241 0.47207531871960984 2.036861856053392e-07 6.691038424700459 0.855372556880801 SCQFVAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SCQFVAVR 8 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 6523300.0 3380500.0 1250000.0 1892800.0 False True 2811035.5315423156 1243266.0018944258 2288575.7286816174 1.0 0.4422804293805172 0.8141397371188535 21.4226702588503 -10.24751595227067 5.64315296434597 1.0000210821559996 0.6282100832496902 0.5713371615024707 0.15181092667728283 4.026845496684882e-05 5.369731283323473e-06 0.14699862098512356 0.04899676589944802 5.655669826062553e-11 10.24751595227067 -0.3718109989063094 SCSFTAACCSHFSSVLAQNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCSFTAACCSHFSSVLAQNR 20 0 P13489;H0YCR7 P13489 RNH1 Ribonuclease inhibitor 0 11719600.0 4418200.0 3782500.0 3518900.0 False True 5792302.98590966 3218165.7440695195 3154797.9836722934 1.0 0.555593474978436 0.544653480894671 22.46570563874058 SCSFTAACCSHFSSVLAQNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCSFTAACCSHFSSVLAQNR 20 0 P13489;H0YCR7 P13489 RNH1 Ribonuclease inhibitor 0 11430300.0 4418200.0 3511900.0 3500200.0 False True 6051727.937365561 3356732.645699724 2673524.848881798 1.0 0.5546734222756513 0.4417787574974226 22.52891570026347 -13.99999999999998 0.19270514652671067 3.409952828418244 0.3629550599696891 0.9994881470550703 0.00545212356722287 12.396023611606166 0.13921110793303287 11.227968606825721 0.07600127868339529 1.000000000000045e-14 13.99999999999998 -3.0469977684485547 SCSLLSLATIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCSLLSLATIK 11 0 Q6UWE0;Q6UWE0-2 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 0 6045950.0 868550.0 1835900.0 3341500.0 False True 1138677.4610501642 1561990.8762821495 2995753.6339313365 1.0 1.3717588427908087 2.6309062367568536 20.118927720021954 -6.948695924925541 0.5729803426139932 0.9845188753744721 3.079679330152521 0.9990949416903532 0.020995591114090273 0.0840136344681274 0.03816221246070124 0.022168672359099712 0.10498974930052977 1.1253926516788354e-07 6.948695924925541 2.095160454778049 up SCSSSCAVHDLIFWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCSSSCAVHDLIFWR 15 0 O95197-3;O95197-6;O95197-5;B7Z4M1 O95197-3 RTN3 Reticulon-3;Reticulon 0 17695700.0 5512700.0 5709700.0 6473300.0 False True 7227203.085062738 4857835.016236277 5803505.01227823 1.0 0.6721597496376578 0.8030084313353498 22.78500600405292 -10.067497219202306 4.895749665515878 1.0000071398647468 0.7375840908800566 0.8428330559426489 0.053418750620623484 4.163099773485016e-06 7.930048462267671e-07 0.05172388913509076 0.01724082762625319 8.560571930567147e-11 10.067497219202306 -0.26242304898469015 SCSSSCAVHDLIFWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCSSSCAVHDLIFWR 15 0 O95197-3;O95197-6;O95197-5;B7Z4M1 O95197-3 RTN3 Reticulon-3;Reticulon 0 14279700.0 5512700.0 3596700.0 5170300.0 False True 7550894.165115914 3437785.9013036177 3949181.625670983 1.0 0.4552819608021673 0.5230084728131478 22.848216065575812 -10.40951927100749 5.947458269166493 1.0001571947254997 0.48914521680820294 0.9869894314404344 0.027649232747564034 5.764820149409519e-05 5.723539980983409e-06 0.026779366708397773 0.008923751497227208 3.894760250481421e-11 10.40951927100749 -0.5110119779172968 SCTVSINFGPCFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCTVSINFGPCFK 13 0 H0YAQ0;H0YBF6;F5H8F7;Q9UBL3-3;Q9UBL3 H0YAQ0 ASH2L Set1/Ash2 histone methyltransferase complex subunit ASH2 0 11979400.0 3192500.0 4153400.0 4633500.0 False True 4185398.41621398 3533728.9098263946 4154069.86767046 1.0 0.844299289677404 0.9925147989682046 21.996933531583046 -10.570364180248625 7.408596580059914 1.00005353702087 0.9184070443249085 0.28778487014971876 0.06050872828820016 5.354205331562282e-05 3.1048747489103055e-06 0.05862571868152333 0.019529108080032404 2.6892787472836597e-11 10.570364180248625 -0.08164649269596158 SCTVSINFGPCFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCTVSINFGPCFK 13 0 H0YAQ0;H0YBF6;F5H8F7;Q9UBL3-3;Q9UBL3 H0YAQ0 ASH2L Set1/Ash2 histone methyltransferase complex subunit ASH2 0 20825000.0 10594000.0 0.0 10231000.0 False True 16071872.525143517 0.0 8208838.365593406 1.0 0.0 0.510758055898661 23.93803469063327 -10.08707459924703 12.84539987888392 1.0000000000254428 0.2553790219901194 0.7391664585466616 0.20851610316127459 0.0 0.0 0.20189484873992114 0.06729828291330703 8.183242116000708e-11 10.08707459924703 -0.7446209780353233 SCTVSINFGPCFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCTVSINFGPCFK 13 0 H0YAQ0;H0YBF6;F5H8F7;Q9UBL3-3;Q9UBL3 H0YAQ0 ASH2L Set1/Ash2 histone methyltransferase complex subunit ASH2 0 15008200.0 3192500.0 4601300.0 7214400.0 False True 4372853.524068528 4397999.351535668 5510507.305231952 1.0 1.0057504390048135 1.2601627918478606 22.060143593105938 -6.9117722542633535 0.8835750446765387 0.9925574802015791 1.2943193217547204 0.9915734183386109 0.01113575199805055 0.10325791364332507 0.13249518612945324 0.009197632199206794 0.025712621077729834 1.225258561236574e-07 6.9117722542633535 0.30176184155314134 SCTVSINFGPCFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCTVSINFGPCFK 13 0 H0YAQ0;H0YBF6;F5H8F7;Q9UBL3-3;Q9UBL3 H0YAQ0 ASH2L Set1/Ash2 histone methyltransferase complex subunit ASH2 0 22334000.0 10594000.0 11740000.0 0.0 False True 13714141.838960128 11086658.679710587 0.0 1.0 0.8084106763585311 0.0 23.70916101272572 -7.237750241781636 0.8622839897715838 0.9895216980571166 2.1941744111071812e-16 0.9889559276470539 0.045542494810343885 0.0970212765877804 0.1385744587376103 0.038538851601052505 0.06779863951453263 5.784286000163427e-08 7.237750241781636 -0.9895216980571164 down SCVEEPEPEPEAAEGDGDK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCVEEPEPEPEAAEGDGDKK 20 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 7625500.0 2964900.0 3090600.0 1570000.0 True False 3887012.6121324394 2629494.527064442 1407551.4605034231 1.0 0.6764821186473807 0.3621165149066063 21.89023035810018 -7.23897758089138 0.25151041310577404 1.1130087297749387 2.526531630760977e-15 0.9999564573977764 0.0017184439540544058 0.09649202625076043 0.014067407871010507 0.012964239640433311 0.04210079666642862 5.767962379445114e-08 7.23897758089138 -1.1130087297749363 down SCVEEPEPEPEAAEGDGDK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCVEEPEPEPEAAEGDGDKK 20 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 1 7306300.0 2964900.0 2845900.0 1495500.0 True False 4061103.6534097926 2720158.727867204 1142293.700789308 1.0 0.6698077567124638 0.2812766672010976 21.95344041962307 -7.274912384950397 0.334014087095758 1.0563171081955232 2.7399921609052184e-13 0.9998017962294368 0.004135404791561016 0.10013363220820781 0.022968342848629735 0.011512545283740468 0.0477181213579615 5.309915562506147e-08 7.274912384950397 -1.0563171081952492 down SCVEEPEPEPEAAEGDGDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCVEEPEPEPEAAEGDGDKK 20 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 0 12499480.0 427180.0 6599600.0 5472700.0 False True 560037.116817005 5614965.405039309 4906437.501845287 1.0 10.026059410048044 8.760914865306134 19.095162920309402 -10.198855429942265 6.882173081613067 0.9999742775786984 9.39348713767709 0.9832459857190445 0.516493097580569 0.0002038569664420425 2.3726256342672576e-05 0.5000936975106156 0.16669743044671842 6.326224067501259e-11 10.198855429942265 8.393512860098392 SCVEEPEPEPEAAEGDGDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCVEEPEPEPEAAEGDGDKK 20 1 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 0 13446380.0 427180.0 7306700.0 5712500.0 False True 585119.9901054328 6983865.833974238 4363325.152630504 1.0 11.935784030752076 7.457145929750711 19.158372981832294 -10.006789115174582 7.646116004659971 0.9999997786218123 9.696464980251394 0.8340874347696139 1.8283963483401309 6.896346745509025e-06 9.108338024146943e-07 1.770337151819612 0.590112383948982 9.844890381530076e-11 10.006789115174582 8.69646520162958 SCVIVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCVIVLR 7 0 Q96SI9-2;Q96SI9 Q96SI9-2 STRBP Spermatid perinuclear RNA-binding protein 0 66737000.0 17414000.0 14061000.0 35262000.0 False True 22829922.63741589 11963153.60934872 31613426.496988352 1.0 0.5240120082466835 1.384736470599213 24.444422634995984 -6.756576397538306 1.6252089704443564 0.7223454439897609 1.387374884047505 0.676878854318705 0.20011665824082836 0.2887157572593252 1.5021343085736765 0.09718770782389428 0.23436755414398666 1.7515542879809488e-07 6.756576397538306 0.6650294400577442 SCVIVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCVIVLR 7 0 Q96SI9-2;Q96SI9 Q96SI9-2 STRBP Spermatid perinuclear RNA-binding protein 0 39437700.0 8442000.0 21802000.0 9193700.0 False True 12807131.1928697 17911262.760196514 7376561.165258141 1.0 1.3985382433006162 0.5759729524255206 23.610444011293573 -6.774941580146454 1.5553525696002708 1.2271449467687967 0.5704358926334805 0.7491582648421918 0.16821477640544052 0.25851616031667696 1.2347925400151984 0.08521188416079252 0.20194987156195957 1.6790298604614548e-07 6.774941580146454 -0.6567090541353162 SCVIVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCVIVLR 7 0 Q96SI9-2;Q96SI9 Q96SI9-2 STRBP Spermatid perinuclear RNA-binding protein 0 56843000.0 17414000.0 19304000.0 20125000.0 False True 23852426.395655233 18451085.45020854 15371889.48738536 1.0 0.7735517193994755 0.6444581038592108 24.507632696518876 -13.999999999894559 0.06432930459997377 2.3784107361926607 0.11583260602346918 0.9999423359404289 0.0011158923737644125 12.419379725021596 0.06650226551151357 2.668302904154195 0.4915888019622383 1.0000000002427868e-14 13.999999999894559 -2.2625781301691914 SCVIVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCVIVLR 7 0 Q96SI9-2;Q96SI9 Q96SI9-2 STRBP Spermatid perinuclear RNA-binding protein 0 27737900.0 8442000.0 11232000.0 8063900.0 False True 10928335.416698268 10606929.32627847 6596352.942601219 1.0 0.9705896572383114 0.6036008862358059 23.381570333386023 -6.922838569783672 0.8034011207840975 1.007299320769113 0.5403777966284568 0.994933579232439 0.012835841816859284 0.09653042575950065 0.0971723255236261 0.011228968298612757 0.034605319872001813 1.1944320004678462e-07 6.922838569783672 -0.46692152414065624 SCVTSCTK(ub)EPETSNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCVTSCTKEPETSNK 15 1 Q9NY74 Q9NY74 ETAA1 Ewings tumor-associated antigen 1 1 5430690.0 556690.0 1654800.0 3219200.0 True False 729825.9809936287 1407910.2903598782 2886108.064746891 1.0 1.9291040974494562 3.9545153775117337 19.477192984613094 -6.958325278788723 0.45842603676578825 0.9400257928087539 5.025026838982297 0.9997029564513576 0.021260077202447235 0.08030487011280123 0.02338336112924975 0.027434560322174673 0.1673489201573653 1.1007145852175864e-07 6.958325278788723 4.085001046173543 SCVTSCTK(ub)EPETSNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCVTSCTKEPETSNK 15 1 Q9NY74 Q9NY74 ETAA1 Ewings tumor-associated antigen 1 1 8361200.0 2180700.0 3083700.0 3096800.0 True False 3308281.330524872 2533389.641941929 2484716.1226243405 1.0 0.765772130249877 0.7510595001998002 21.65765049334218 -13.999999999999991 0.39356658522057425 4.788760101260231 0.7500628241620959 0.9998284676888533 0.0014936029441574982 25.843578071325705 0.206025998919343 83.41140728114414 0.0038329966804129634 1.0000000000000205e-14 13.999999999999991 -4.0386972770981355 SCVTSCTK(ub)EPETSNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCVTSCTKEPETSNK 15 1 Q9NY74 Q9NY74 ETAA1 Ewings tumor-associated antigen 1 1 5192990.0 556690.0 1288100.0 3348200.0 True False 762513.3369815843 1231187.4828229179 2557424.1183435335 1.0 1.6146438666851182 3.3539401795477035 19.540403046135985 -6.952756038803071 0.5277190487808884 0.9721116830466549 4.075122264812077 0.9994002036122972 0.02441439117195713 0.08239754957784047 0.03152546352986296 0.027330458929722266 0.14378929119532785 1.1149206548227594e-07 6.952756038803071 3.103010581765422 SCVTSCTK(ub)EPETSNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCVTSCTKEPETSNK 15 1 Q9NY74 Q9NY74 ETAA1 Ewings tumor-associated antigen 1 1 8005400.0 2180700.0 2170200.0 3654500.0 True False 2822959.138023445 2049426.4622408783 2989418.4983365526 1.0 0.7259851673502535 1.0589662663093515 21.42877681543463 -6.68806169430001 1.8730962716064765 0.8279000601480628 1.0577954144701074 0.3614353741817057 0.11593490767746738 0.420863130148902 2.861265409856432 0.04954073575389126 0.12933345005027813 2.0508708188560878e-07 6.68806169430001 0.22989535432204455 SCYDLSCHAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCYDLSCHAR 10 0 P41250 P41250 GARS Glycine--tRNA ligase 0 8589100.0 1824300.0 3435500.0 3329300.0 False True 2391674.966546333 2922936.791474113 2984815.9729006714 1.0 1.2221296088970408 1.2480023475810578 21.18958990701481 -12.858987740262565 0.3201158556239056 0.003134884049423633 1.2533282847103577 0.9996295682111386 0.002142397883266486 8.827088297123122 0.17716931014007908 5.7651058678254055 0.00861162531900801 1.383605436341037e-13 12.858987740262565 1.250193400660934 SCYDLSCHAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCYDLSCHAR 10 0 P41250 P41250 GARS Glycine--tRNA ligase 0 27271900.0 3659000.0 19494000.0 4118900.0 False True 5550970.508731362 16015143.392682804 3304797.6096219956 1.0 2.885106913735515 0.5953549211662602 22.40430859767497 -6.687996807913959 1.8734160501629178 2.1840806192881157 0.6034469745480515 0.3610168525295524 0.7976005547203434 0.42104811249915036 2.863472085062207 0.34078077090106 0.8897026655812635 2.0511772550249973e-07 6.687996807913959 -1.5806336447400642 SCYDLSCHAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCYDLSCHAR 10 0 P41250 P41250 GARS Glycine--tRNA ligase 0 7138500.0 1824300.0 2442500.0 2871700.0 False True 2498793.009853788 2334582.2737326147 2193463.6045179907 1.0 0.9342839781151854 0.877809244650615 21.2527999685377 -6.972890640553834 0.17592546156231956 1.0460879736508037 0.7644841860138855 0.9999970253479772 8.592434897566388e-05 0.07537534609064626 0.005522975925719491 0.002255229311070321 0.006418254149344874 1.0644110132121444e-07 6.972890640553834 -0.2816037876369183 SCYLSSLDLLLEHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SCYLSSLDLLLEHR 14 0 Q9BQ69 Q9BQ69 MACROD1 O-acetyl-ADP-ribose deacetylase MACROD1 0 8175800.0 1633400.0 4165800.0 2376600.0 False True 2141403.2178681027 3544278.8781612217 2130692.229956967 1.0 1.6551198058298273 0.9949981452247002 21.030125044471898 -6.647946593029548 2.016074873466711 1.4258052274045356 0.997782919645851 0.18566837168863437 0.2797559377092462 0.513592544790769 3.999005813040264 0.11263487235371122 0.3097984324421819 2.2493311982948494e-07 6.647946593029548 -0.42802230775868466 SCYLSSLDLLLEHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SCYLSSLDLLLEHR 14 0 Q9BQ69 Q9BQ69 MACROD1 O-acetyl-ADP-ribose deacetylase MACROD1 0 25902800.0 4893500.0 12671000.0 8338300.0 False True 7423797.262770419 10409761.051025145 6690231.350193284 1.0 1.4022151578989135 0.9011872379306622 22.823725881622973 -6.692969534775704 1.855671662896814 1.2514564159521226 0.9028454684533894 0.38442728715807917 0.1700073670881765 0.4103281496658519 2.741706521801159 0.07322530992629295 0.18998664977416246 2.027824963961757e-07 6.692969534775704 -0.3486109474987332 SCYLSSLDLLLEHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SCYLSSLDLLLEHR 14 0 Q9BQ69 Q9BQ69 MACROD1 O-acetyl-ADP-ribose deacetylase MACROD1 0 11353700.0 1633400.0 2608300.0 7112000.0 False True 2237312.120975266 2493056.681505336 5432292.076237749 1.0 1.114308843246506 2.4280439127419378 21.09333510599479 -6.92402402774471 0.7942905899374337 0.9749988001351471 2.66084530797299 0.9952281780124579 0.04475769214293456 0.09586120736526679 0.093759578084935 0.03940960564762603 0.1230059703713412 1.1911761032823904e-07 6.92402402774471 1.6858465078378428 up SCYLSSLDLLLEHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SCYLSSLDLLLEHR 14 0 Q9BQ69 Q9BQ69 MACROD1 O-acetyl-ADP-ribose deacetylase MACROD1 0 20536100.0 4893500.0 8520300.0 7122300.0 False True 6334732.215305966 8046137.815054361 5826114.480969338 1.0 1.2701622644147925 0.9197096708985255 22.594852203715423 -6.700811591564179 1.827841073255462 1.1676261496771276 0.9207320216892841 0.4214655843316091 0.11402206578121343 0.3938508478328679 2.558745414373945 0.049753907555774024 0.12783225014138727 1.99153713310115e-07 6.700811591564179 -0.2468941279878435 SDALETLGFLNHYQMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDALETLGFLNHYQMK 16 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 49673100.0 9057400.0 24233300.0 16382400.0 False True 11874339.111986361 20617786.100663535 14687306.399077259 1.0 1.7363312523095489 1.2368946398247456 23.501343884064163 -10.22169903746012 4.088646363616853 0.999703468633434 1.486612946026785 0.5586435419674421 0.20389414385091717 28256376.89000495 23547392.911094125 71591.70982213321 0.06979838885044357 6.002068706422049e-11 10.22169903746012 0.486909477393351 SDALETLGFLNHYQMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 SDALETLGFLNHYQMK 16 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 86985400.0 29298800.0 14472600.0 43214000.0 False True 28368725.63135232 20251584.65361198 31894957.00778878 1.0 0.7138700876725494 1.1242999570110885 24.757798008104654 -6.7192541948764095 1.7620025516783255 0.8257828883397724 1.1236330245242485 0.5089818981587004 0.12041575724081495 0.3567747557794379 2.164331288183168 0.05427167819724427 0.13636167927152684 1.9087357383456682e-07 6.7192541948764095 0.2978501361844761 SDALETLGFLNHYQMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDALETLGFLNHYQMK 16 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 93403000.0 5116400.0 81321000.0 6965600.0 False True 7761952.858943201 66808632.186127044 5588846.106869067 1.0 8.607193756549446 0.7200309262932054 22.88798824048214 -6.6544110854737815 1.9928333165281198 5.919071791458689 0.7532448781241352 0.21206576907035468 3.2433578234667984 0.4978500487565498 3.794649111238312 1.3176701795240622 3.5933662475365047 2.2160977587958216e-07 6.6544110854737815 -5.165826913334554 SDALETLGFLNHYQMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDALETLGFLNHYQMK 16 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 61255900.0 9057400.0 22723200.0 29475300.0 False True 12406165.547031555 21719213.888426173 22513841.202858593 1.0 1.7506790318159964 1.8147300322173694 23.564553945587054 -11.205946555692986 0.4270005094757997 3.975312543280546e-11 1.8170567861724796 0.9996632627851382 0.006787734993794007 3.2478779379013014 0.21028934183660553 3.112160087320709 0.015244672333034238 6.22376870194658e-12 11.205946555692986 1.8170567861327265 SDALETLGFLNHYQMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SDALETLGFLNHYQMK 16 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 50587200.0 29298800.0 10650400.0 10638000.0 False True 24363250.35691527 10593024.181261115 12862356.615445392 1.0 0.4347951946507987 0.527940912112104 24.53820328353893 -10.817681593928548 7.326121870755218 1.0239426602382626 0.4813680533814522 0.9763796012141936 0.038026579917607904 0.013375746691318767 0.0003328693582409862 0.0331173263484224 0.012273025894510075 1.52166273867144e-11 10.817681593928548 -0.5425746068568105 SDALETLGFLNHYQMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDALETLGFLNHYQMK 16 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 22136500.0 5116400.0 10922300.0 6097800.0 False True 6623280.659321842 10314464.403526653 4988062.96871163 1.0 1.5573044438347494 0.753110614705909 22.65911456257459 -6.7203103724197755 1.758323541476321 1.338945409439315 0.7543525833357055 0.5139405726954849 0.23450654849527494 0.35470731542758166 2.1434050854048077 0.10589328969854794 0.26572220604156005 1.9040994499682043e-07 6.7203103724197755 -0.5845928261036094 SDALETLGFLNHYQMK(ub)NPNGPYPYTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDALETLGFLNHYQMKNPNGPYPYTLK 27 1 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 85338000.0 45959000.0 24441400.0 14937600.0 True False 44500056.7016847 34200978.48021719 11024994.441605631 1.0 0.7685603348663238 0.2477523683961563 25.40730383856444 -6.9929313026236235 0.4776612886300233 1.0127647430164228 6.021166243930816e-13 0.9996701461026093 0.005713478689136521 0.0759236996773185 0.02464901402306688 0.007154103649366854 0.040355968341072176 1.0164094573836243e-07 6.9929313026236235 -1.0127647430158206 down SDALETLGFLNHYQMK(ub)NPNGPYPYTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDALETLGFLNHYQMKNPNGPYPYTLK 27 1 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 108545000.0 32519000.0 36291000.0 39735000.0 True False 49333700.457347676 29814587.50712281 31881359.833530825 1.0 0.6043452494081514 0.6462389712909214 25.556070170300025 -10.166398343576688 8.033848911631166 1.000000075277138 0.6252921106891243 0.9907120265873053 0.017103040339809413 2.305874876597661e-08 2.395797990204783e-09 0.016559951056041192 0.005519982533799622 6.817131263926799e-11 10.166398343576688 -0.3747079645880138 SDALETLGFLNHYQMK(ub)NPNGPYPYTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDALETLGFLNHYQMKNPNGPYPYTLK 27 1 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 7460400.0 1297200.0 3111000.0 3052200.0 True False 1776809.8955118826 2973545.7332987394 2331333.2220321787 1.0 1.6735306015628015 1.312089283114074 20.760857902084293 -10.042420013903863 4.312677674265655 0.9999646442137975 1.4928099422405496 0.7125353929361119 0.14755780067417126 34042471.66159683 54979183.186666995 16115.603158333452 0.054000628678753076 9.06942985239153e-11 10.042420013903863 0.49284529802675214 SDALETLGFLNHYQMK(ub)NPNGPYPYTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDALETLGFLNHYQMKNPNGPYPYTLK 27 1 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 96695300.0 45959000.0 42292000.0 8444300.0 True False 38216944.828916796 42064164.60169526 10209964.087968178 1.0 1.1006679050353463 0.2671580403319635 25.187709113998718 -6.8767128487050435 1.0979128985411415 1.0600577389305 0.21167598766736948 0.9709383347952186 0.06332680256329483 0.13058433028382335 0.2901895083840813 0.04455352728331925 0.10690227127494482 1.3282724082719866e-07 6.8767128487050435 -0.8483817512631304 down SDALETLGFLNHYQMK(ub)NPNGPYPYTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SDALETLGFLNHYQMKNPNGPYPYTLK 27 1 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 143039400.0 44813000.0 56905400.0 41321000.0 True False 58011311.896292284 53738564.4661332 33801001.98926388 1.0 0.9263463057377923 0.5826622581763097 25.789830909718322 -6.9413582553750794 0.6468114894088831 1.0037855369592386 0.4861594794305574 0.9983363512978992 0.007418384412856587 0.08715263361127681 0.05183014228596628 0.007297793219083085 0.029407740884721173 1.1445683820150554e-07 6.9413582553750794 -0.5176260575286812 SDAYYCTGDVTAWTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDAYYCTGDVTAWTK 15 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 46347000.0 11727000.0 17962000.0 16658000.0 False True 15374210.564429559 15282139.615327625 14934389.954819126 1.0 0.9940113380966075 0.971392312615516 23.874008997003408 -6.946199248197145 0.5991772920878123 1.0002552366147102 0.9639922908074797 0.9988675165052147 0.00041453342040223735 0.08505003266089477 0.042571948001200705 0.0004257997756912274 0.0019003104642409498 1.1318809530415731e-07 6.946199248197145 -0.03626294580723044 SDAYYCTGDVTAWTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDAYYCTGDVTAWTK 15 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 48830000.0 11727000.0 17109000.0 19994000.0 False True 16062788.810258936 16353067.80810288 15271828.989355654 1.0 1.0180715192905077 0.9507582506222011 23.9372190585263 -6.835235215825092 1.304193013414382 1.009627495676657 0.9487432118642275 0.9159677863356134 0.008245917561722027 0.17444165404616666 0.5783854466851699 0.00496109004798987 0.01141979904006873 1.4613854672041383e-07 6.835235215825092 -0.06088428381242961 SDDNEK(ub)ALK(ub)IR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDDNEKALKIR 11 2 P54819;F8W1A4;P54819-2;P54819-5;A0A5K1VW67;P54819-6;F8VY04 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 2 2075040.0 444220.0 828190.0 802630.0 True False 582376.7218325987 704627.2802593345 719581.5469706146 1.0 1.2099166292945962 1.2355946245692402 19.151593165193475 -12.98734760309208 0.3106428107604054 4.517901173612445e-10 1.2414294001891806 0.999616276214423 0.002067204759360818 9.359413429055932 0.17437339706953203 5.934722862168084 0.00887759165712418 1.0295617440808275e-13 12.98734760309208 1.2414293997373904 SDDNEK(ub)ALK(ub)IR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDDNEKALKIR 11 2 P54819;F8W1A4;P54819-2;P54819-5;A0A5K1VW67;P54819-6;F8VY04 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 2 3286410.0 909410.0 1084300.0 1292700.0 True False 880541.2773358668 1517266.6445497996 954103.0898312702 1.0 1.7231067794350148 1.0835415833292554 19.74803110962555 -10.22840385443906 4.311004076095997 0.9998107108496499 1.4033241813938504 0.34651041042851016 0.2611013979916869 184059758.97066057 117.3592954080903 347577.89553478354 0.08938195341647556 5.9101179125453e-11 10.22840385443906 0.4035134705442005 SDDNEK(ub)ALK(ub)IR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDDNEKALKIR 11 2 P54819;F8W1A4;P54819-2;P54819-5;A0A5K1VW67;P54819-6;F8VY04 P54819 AK2 Adenylate kinase 2, mitochondrial;Adenylate kinase 2, mitochondrial, N-terminally processed;Adenylate kinase 2, mitochondrial 2 2198240.0 444220.0 705620.0 1048400.0 True False 608460.138594117 674443.3752266973 800789.5124757668 1.0 1.1084429898481738 1.316091986446373 19.214803226716366 -6.960887119791922 0.42274637214949395 0.9910884161636141 1.4413149865987027 0.9998016948813173 0.0018467921772498677 0.07938575066030448 0.019971657658981474 0.0026911511824573215 0.017272352464091315 1.094240740301247e-07 6.960887119791922 0.4502265704350886 SDEAVK(ub)PFGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDEAVKPFGLK 11 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 8590700.0 1945500.0 2608500.0 4036700.0 True False 2550569.3402488 2219321.967853364 3619021.0067606233 1.0 0.870128066244565 1.4189071238532176 21.282387891965815 -6.8442957462288625 1.2623044075323446 0.9309018385116785 1.4385465305560103 0.9315913163691903 0.06124654767462757 0.16383887466635094 0.505252091126237 0.03801631901436619 0.08770946003387323 1.4312129387316495e-07 6.8442957462288625 0.5076446920443318 SDEAVK(ub)PFGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDEAVKPFGLK 11 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 3825000.0 1264700.0 2560300.0 0.0 True False 1224552.7907617788 3582641.1417881204 0.0 1.0 2.925673085567348 0.0 20.223823539492738 -6.729248309244045 1.7266609599939158 2.159898464754906 0.002246892503488585 0.5554302291381081 0.8095577559116706 0.3376763185180304 1.9720735715613904 0.3716571522854223 0.9227850560446431 1.8653128873447987e-07 6.729248309244045 -2.157651572251418 SDEAVK(ub)PFGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDEAVKPFGLK 11 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 45381600.0 4525600.0 7451000.0 33405000.0 True False 6865666.065677699 6121310.835071286 26802487.108068354 1.0 0.8915829544452307 3.9038436841630344 22.710968258092297 -6.898547937876226 0.9703741180843767 0.8697228995489462 4.210900799189446 0.9858307761499262 0.16607003369154819 0.11248298147281503 0.18349684043305606 0.12869528367387265 0.3324791660815889 1.26314166922194e-07 6.898547937876226 3.3411778996404995 up SDEAVK(ub)PFGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDEAVKPFGLK 11 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 10962600.0 1945500.0 2330300.0 6686800.0 True False 2664803.9251606315 2227339.6407284 5107515.55896886 1.0 0.8358362203305966 1.9166571734394995 21.345597953488706 -6.868177206729599 1.1436112098017222 0.9080927360691217 1.977822938693788 0.9628342665433348 0.09167972082892048 0.138619064466757 0.3399599054667893 0.06227914748141428 0.14700853439805647 1.3546365623700786e-07 6.868177206729599 1.0697302026246662 SDEAVK(ub)PFGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDEAVKPFGLK 11 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 12008000.0 1264700.0 2750900.0 7992400.0 True False 1051654.0857096768 2736080.355689105 9663573.887317698 1.0 2.6016923177194187 9.188928202372294 20.004228814927014 -6.944236722001639 0.6188935765625905 0.9278468216561458 11.211092402303041 0.9986678315350801 0.1293384326014636 0.08588585553242471 0.04619937552369887 0.13038546034291942 0.557248415671905 1.1370073653815e-07 6.944236722001639 10.283245580646895 SDEAVK(ub)PFGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDEAVKPFGLK 11 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 44604600.0 4525600.0 6857000.0 33222000.0 True False 5858478.41291278 6475401.922212568 27175936.886506222 1.0 1.1053043923384638 4.638736369943301 22.482094580184746 -6.913265813868447 0.8732065166335915 0.9015719860645199 5.128758100427566 0.9920966199922298 0.1503353251279496 0.10229762787953146 0.12734832803892931 0.12510467062488415 0.35367989357383295 1.2210520754307015e-07 6.913265813868447 4.227186114363047 up SDEAVKPFGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDEAVKPFGLK 11 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 12422800.0 1784200.0 4973600.0 5665000.0 False True 2339103.4782173806 4231558.266940955 5078840.142517129 1.0 1.8090513337040588 2.171276384227212 21.15752425496017 -10.049765347358955 0.19081360219721535 1.2599124544839492e-16 2.5232310516692245 0.9994749807213219 0.011219093300666247 1.5933287078283334 0.08880945315924593 1.0467852138310667 0.2322496844742534 8.91732617970395e-11 10.049765347358955 2.5232310516692245 SDEAVKPFGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDEAVKPFGLK 11 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 6924700.0 1784200.0 0.0 5140500.0 False True 2443866.956192035 0.0 3926419.771920715 1.0 0.0 1.6066421954649903 21.22073431648306 -6.7384033744299545 1.692683390954663 0.40389488003008733 1.6072311711966971 0.5976689344559487 0.4201761096911654 0.3207246850784944 1.8037329418516845 0.19643067341863416 0.4828442813191404 1.8264030577279855e-07 6.7384033744299545 1.2033362911666097 SDEEEQQYVIK(ub)CGTCTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDEEEQQYVIKCGTCTK 17 1 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 31834900.0 3173800.0 3815100.0 24846000.0 True False 4108546.6649510674 3602786.3312575733 20324282.941488575 1.0 0.8769004285607847 4.946830253838832 21.97019672233936 -6.899924316275179 0.9617347811428778 0.8304356663123985 5.373399072138778 0.9865289525195331 0.21939001750547324 0.11146139834764379 0.17772928046793116 0.17111323881277085 0.4450442434491742 1.2591448215979793e-07 6.899924316275179 4.542963405826379 up SDFFELLSNHHLDSQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDFFELLSNHHLDSQSR 17 0 O14776;O14776-2;G3V220 O14776 TCERG1 Transcription elongation regulator 1 0 10570500.0 2308200.0 4215800.0 4046500.0 False True 3026072.552640594 3586819.0730596897 3627806.9967688564 1.0 1.1853050482645502 1.1988499725834993 21.529015147123367 -12.803509801909861 0.3876753096266916 7.442566082323493e-12 1.199933311370471 0.9997789576084926 0.0013486909159657664 9.892135638360589 0.20179982657163031 8.011815925193048 0.003589218615416137 1.5721363093680886e-13 12.803509801909861 1.1999333113630286 SDFFELLSNHHLDSQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDFFELLSNHHLDSQSR 17 0 O14776;O14776-2;G3V220 O14776 TCERG1 Transcription elongation regulator 1 0 7849000.0 2948500.0 2039800.0 2860700.0 False True 2854901.4814273007 2854302.7774164756 2111396.8508395706 1.0 0.9997902890818755 0.7395690760523138 21.445009530425907 -6.907071979870242 0.9154490588829282 1.008821884791758 0.7079644550497481 0.9897687742644006 0.012412958267526301 0.10638606170823721 0.1495079202317909 0.0100177633921472 0.027123280595497744 1.2385912856750706e-07 6.907071979870242 -0.3008574297420099 SDFFELLSNHHLDSQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDFFELLSNHHLDSQSR 17 0 O14776;O14776-2;G3V220 O14776 TCERG1 Transcription elongation regulator 1 0 12540000.0 2308200.0 4056100.0 6175700.0 False True 3161603.9167595813 3876888.0902709733 4717126.852533944 1.0 1.226240918326198 1.4920043676339643 21.59222520864626 -6.96900109776483 0.28102110951076587 0.9421661872223875 1.784188811386865 0.9999735085777344 0.0010349176270058407 0.07662816394370922 0.010185173678390736 0.004880270342454916 0.024362464581871742 1.073986697624933e-07 6.96900109776483 0.8420226241644774 SDFFELLSNHHLDSQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDFFELLSNHHLDSQSR 17 0 O14776;O14776-2;G3V220 O14776 TCERG1 Transcription elongation regulator 1 0 6954000.0 2948500.0 2515600.0 1489900.0 False True 2451808.390697386 2502047.9634924983 1801431.2014807386 1.0 1.020490823420676 0.7347357192820211 21.225414805860183 -6.889672888399706 1.02434364734404 1.0154746413082871 0.7103175950996883 0.9806870950737631 0.018086453160539192 0.11940782855858438 0.22341491187665366 0.013459468958135 0.033514529318375806 1.2892202297240348e-07 6.889672888399706 -0.30515704620859885 SDGAEGQGQGQLLIK(ub)TVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDGAEGQGQGQLLIKTVK 18 1 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 12705500.0 1680600.0 3700700.0 7324200.0 True False 2203282.8749535503 3148569.9852156164 6566362.042687381 1.0 1.429035745254451 2.980262823867232 21.07122330090126 -6.9471978410012944 0.5888039156457896 0.9820053356889424 3.505188681448548 0.9989626381348926 0.027396494781252858 0.0846308431355584 0.04077224913690414 0.028438073599707837 0.1299079206604351 1.129281358167299e-07 6.9471978410012944 2.5231833457596053 up SDGAEGQGQGQLLIK(ub)TVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDGAEGQGQGQLLIKTVK 18 1 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 10995400.0 1701000.0 3208100.0 6086300.0 True False 1647002.6860803266 4489111.060020494 4492115.444913794 1.0 2.7256246137060365 2.7274487667075413 20.651411477267377 SDGAEGQGQGQLLIK(ub)TVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDGAEGQGQGQLLIKTVK 18 1 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 23145900.0 5641300.0 9066800.0 8437800.0 True False 8558264.53427338 7448758.700768263 6770065.131580879 1.0 0.8703585488551018 0.791055839004359 23.02888684239472 SDGAEGQGQGQLLIK(ub)TVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDGAEGQGQGQLLIKTVK 18 1 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 6114800.0 1680600.0 0.0 4434200.0 True False 2301963.2365073026 0.0 3386933.2852156092 1.0 0.0 1.4713237950552582 21.13443336242415 -6.7236956882785615 1.7461175622078933 0.39402568499630164 1.469505850145072 0.529865125850441 0.42062368116620624 0.34818044975214324 2.0765948105128205 0.19113106244763065 0.4777193074418361 1.889314735090988e-07 6.7236956882785615 1.0754801651487704 SDGAEGQGQGQLLIK(ub)TVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDGAEGQGQGQLLIKTVK 18 1 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 10254600.0 1701000.0 3735600.0 4818000.0 True False 1414456.867076906 3715475.581341459 5825421.524084971 1.0 2.6267860603058204 4.118486508622702 20.431816752701653 -6.972161983600045 0.19991385205947929 0.1111164632522664 6.67533797048142 0.9999946988094662 0.0029321750015341925 0.07560721857737857 0.006454247799185462 0.04846498026262593 0.15839673395370965 1.0661983752985293e-07 6.972161983600045 6.564221507229154 SDGAEGQGQGQLLIK(ub)TVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDGAEGQGQGQLLIKTVK 18 1 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 18884600.0 5641300.0 9297700.0 3945600.0 True False 7302774.05664771 8780274.821664847 3227541.28527479 1.0 1.202320481717789 0.44196099458078697 22.80001316448717 -6.835911970986006 1.3010405154326177 1.1077591605794583 0.41888045274543606 0.9172147663520797 0.09251464625557308 0.17364002232284542 0.5726693959357061 0.05578889119091175 0.12843434843838783 1.4591099835736173e-07 6.835911970986006 -0.6888787078340223 down SDGAPASDSKPGSSEAAPSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDGAPASDSKPGSSEAAPSSK 21 1 P80723-2;P80723 P80723-2 BASP1 Brain acid soluble protein 1 0 3019090.0 645740.0 1475800.0 897550.0 False True 979634.789917516 1212431.959521972 720148.8490898592 1.0 1.237636690734572 0.735119716553242 19.901884483894275 -6.778102884099832 1.5431588639905294 1.1348875845717614 0.7313663130323201 0.760648449691665 0.10041668359528046 0.2535365979233462 1.1923859038769338 0.051258035987685 0.12114586113276651 1.666852289476161e-07 6.778102884099832 -0.4035212715394413 SDGIYIINLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDGIYIINLK 10 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 135052000.0 40129000.0 39751000.0 55172000.0 False True 52609507.60978878 33820305.74818438 49463330.68719427 1.0 0.6428553941054489 0.9401975599937165 25.648820211675606 -10.01785689667446 6.779766510223726 1.0000000457456693 0.7915264770495822 0.3959280193454148 0.12138943090670937 8.391763419058513e-08 1.2141432824670053e-08 0.11753483734784091 0.03917827035893985 9.59716813389556e-11 10.01785689667446 -0.20847356869608702 SDGIYIINLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDGIYIINLK 10 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 106424000.0 34373000.0 18460000.0 53591000.0 False True 33281847.929828975 25831174.26762825 39553909.40446165 1.0 0.776134015217255 1.1884529214800996 24.988232203615595 -6.759269753144892 1.6153420839923487 0.8698474359179942 1.1898987485232642 0.6879344072236488 0.09414859713495217 0.2841448404407923 1.4611376307835295 0.04599137760393529 0.11059892851734217 1.7407253215636273e-07 6.759269753144892 0.32005131260527 SDGIYIINLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDGIYIINLK 10 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 76146000.0 17980000.0 44057000.0 14109000.0 False True 27276974.514072146 36194684.13108787 11320349.96580562 1.0 1.3269317721587888 0.41501486757504835 24.701180297737693 -6.8097557588032585 1.4156229347126081 1.1782241671767584 0.3991591681260574 0.8591784913413771 0.14155796348888505 0.20713065995945817 0.8181586404783665 0.07863048630649078 0.18190332936068873 1.5496878968847282e-07 6.8097557588032585 -0.779064999050701 down SDGIYIINLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDGIYIINLK 10 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 155256000.0 40129000.0 60371000.0 54756000.0 False True 54965775.74544897 57703609.5998001 41823760.53521847 1.0 1.0498097919518186 0.760905490152777 25.712030273198497 -6.862456982253098 1.1731836811502163 1.0272240284271572 0.746239355591611 0.9565618359302609 0.026281724011379938 0.14429663889333236 0.375988295615516 0.017453578278397934 0.04086333475526174 1.3725969127749328e-07 6.862456982253098 -0.2809846728355462 SDGIYIINLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDGIYIINLK 10 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 79111000.0 34373000.0 23030000.0 21708000.0 False True 28582672.482089657 22905932.818902895 26247042.43354844 1.0 0.8013922712530155 0.9182851061248818 24.768637479049872 -10.213372282118186 4.9635269821915555 1.00001746544778 0.8598386887105245 0.6571805521083631 0.047721300004504905 9.224405708267429e-06 1.4619489467242738e-06 0.04621170554803965 0.015401983347983513 6.118257029932122e-11 10.213372282118186 -0.14017877673725554 SDGIYIINLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDGIYIINLK 10 0 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 0 55154000.0 17980000.0 22302000.0 14872000.0 False True 23275464.438786387 21060874.09496639 12165448.599606294 1.0 0.904853011649057 0.5226726466232704 24.472306619830142 -6.944778671263822 0.6134969350394487 1.00420815815394 0.40329491946897184 0.9987251897460269 0.00736505389134535 0.08565260040527319 0.045178981679652876 0.007461829999382161 0.03226658182865565 1.1355893966645065e-07 6.944778671263822 -0.600913238684968 SDGIYIINLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDGIYIINLKR 11 1 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 1 4142200.0 1249500.0 1658900.0 1233800.0 True False 1638106.600175211 1411398.5863415536 1106138.2114453036 1.0 0.86160362591213 0.6752541082045526 20.643597813079662 -6.966989391274431 0.32209059371193993 1.0249024774621953 0.5059261348616932 0.9999484711239471 0.0009551201303988087 0.07729224854793931 0.012513332086877153 0.002801162077521542 0.0163617234993055 1.0789730785156187e-07 6.966989391274431 -0.5189763426005021 SDGIYIINLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDGIYIINLKR 11 1 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 1 6276200.0 1988800.0 2148000.0 2139400.0 True False 1925666.632614083 3005707.6016720245 1579026.9593757412 1.0 1.5608660142756856 0.8199897804908318 20.876926537769116 -6.704254058026973 1.8156271549523593 1.3468180374461074 0.8220068701122876 0.43776574384294475 0.23657038047999343 0.38676823985909287 2.4815668439546865 0.10383212591137958 0.2656426429566702 1.975813470402922e-07 6.704254058026973 -0.5248111673338198 SDGIYIINLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDGIYIINLKR 11 1 C9J9K3;A0A0C4DG17;P08865;F8WD59 C9J9K3 RPSA 40S ribosomal protein SA 1 6924000.0 1988800.0 2446900.0 2488300.0 True False 1653775.3187786902 2433718.064028378 3008592.0254007117 1.0 1.4716134872696456 1.8192265849163543 20.657331813203392 -6.974464926598607 0.10698058507405003 0.23347302161300348 3.0662215956665637 0.9999996609993738 0.00019538497786049445 0.07487877829099188 0.0031552237400710725 0.028663263748227467 0.054277709185560054 1.0605595851663846e-07 6.974464926598607 2.8327485740535603 SDIDEIVLVGGSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDIDEIVLVGGSTR 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 63673000.0 17044000.0 22973000.0 23656000.0 False True 22344849.054330774 19545517.94805262 21208304.044375174 1.0 0.8747214134464872 0.9491361518177129 24.413438963171178 -10.166669631492338 4.609919358626975 1.000012683756099 0.9119287826317442 0.6512789099217876 0.030379689729063797 3.960851833925634e-06 7.160268008208225e-07 0.02941924359844165 0.009805002698113026 6.812874180540789e-11 10.166669631492338 -0.08808390112435482 SDIDEIVLVGGSTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDIDEIVLVGGSTR 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 53227300.0 13490000.0 7876300.0 31861000.0 False True 13061767.33405267 11021347.664361903 23515648.290488213 1.0 0.8437868614937512 1.8003419973024446 23.63884677943962 -6.865012985778086 1.160242746085574 0.913835467847513 1.8512785267143628 0.959442358778563 0.08437939915678913 0.141721117588256 0.35973030352224433 0.05659837269232862 0.13294696990770133 1.3645423349909112e-07 6.865012985778086 0.9374430588668498 SDIDEIVLVGGSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDIDEIVLVGGSTR 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 68491000.0 17044000.0 21897000.0 29550000.0 False True 23345627.396781176 20929518.136304215 22570898.601353396 1.0 0.8965069895354327 0.9668148222251419 24.47664902469407 -10.067242502946469 4.729370647303913 1.000002650411195 0.9316609058789285 0.5574648590252087 0.028703052506458125 8.021753940307435e-07 1.581546338158775e-07 0.027792689074247045 0.009263870361241185 8.565594228774553e-11 10.067242502946469 -0.06834174453226649 SDIGEVILVGGMTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDIGEVILVGGMTR 14 0 P38646;H0YBG6 P38646 HSPA9 Stress-70 protein, mitochondrial 0 15483100.0 3460100.0 5630200.0 6392800.0 False True 4536224.607656061 4790196.106347706 5731334.380067706 1.0 1.0559874169949615 1.263459126427423 22.113060645302973 -6.9466327425279415 0.5946699935420614 0.9976330055315161 1.3323371936059305 0.9989097865045712 0.0037419138554105956 0.08486684556322567 0.04178124517587039 0.003860950616774517 0.01740576459808836 1.1307517211535632e-07 6.9466327425279415 0.3347041880744144 SDIGEVILVGGMTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDIGEVILVGGMTR 14 0 P38646;H0YBG6 P38646 HSPA9 Stress-70 protein, mitochondrial 0 17275200.0 3460100.0 6252500.0 7562600.0 False True 4739392.475686607 5976243.8757474655 5776469.636636042 1.0 1.2609725627084034 1.2188206961693315 22.176270706825864 -10.137177791094068 4.626886466861507 0.9999755745909391 1.2398966294425717 0.9773689257908608 0.017208427467099358 4.3362920857205306e-06 8.086199564835237e-07 0.016663683527183226 0.005553996081086776 7.29158946695865e-11 10.137177791094068 0.23992105485163262 SDIIAK(ub)NSLTDTWNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDIIAKNSLTDTWNK 15 1 E9PPJ1;Q8NG31-3;Q8NG31-4;Q8NG31-2;Q8NG31 E9PPJ1 CASC5 Protein CASC5 1 16876800.0 5202000.0 6599700.0 5075100.0 True False 6734091.546750106 6232420.893397446 4151483.874923475 1.0 0.9255028462458655 0.6164875909545653 22.683051903371325 -6.944041168988648 0.6208367317389066 1.0033802080682375 0.5222158226044824 0.9986466698136494 0.006108197792244186 0.08597061181295472 0.046571975844879 0.006146729510656702 0.026160296830186933 1.1375194494428754e-07 6.944041168988648 -0.48116438546375506 SDIK(ub)GQHTETLLAGSLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDIKGQHTETLLAGSLAK 18 1 F5H6X0;F5GXG6;F5GX35;F5H4K7;F5GWD3;Q13889-2;Q13889;H0YFF7 F5H6X0 GTF2H3 General transcription factor IIH subunit 3 1 13518900.0 4101600.0 3910300.0 5507000.0 True False 5377237.319950907 3326898.4822300174 4937188.466874116 1.0 0.6187003258878653 0.9181645095997347 22.358433714502894 -9.844818466097571 6.1607657882318145 1.000000017695991 0.7684324177436859 0.44360003793052605 0.12225574105593438 2.9652776015242813e-08 5.5830945984172964e-09 0.11837362020935262 0.039457870757263536 1.42949135711396e-10 9.844818466097571 -0.23156759995230503 SDIK(ub)GQHTETLLAGSLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDIKGQHTETLLAGSLAK 18 1 F5H6X0;F5GXG6;F5GX35;F5H4K7;F5GWD3;Q13889-2;Q13889;H0YFF7 F5H6X0 GTF2H3 General transcription factor IIH subunit 3 1 12110700.0 3318900.0 4536500.0 4255300.0 True False 3213543.336174014 6347948.107534976 3140709.2737363726 1.0 1.9753734253643913 0.9773352792172529 21.61573349726484 -6.651552106657761 2.0045640338011683 1.6321930940689577 0.9816574599214088 0.19985375322170973 0.416152028930533 0.5046614336412012 3.889277177237524 0.16832910345151464 0.46053588993606365 2.230734547864414e-07 6.651552106657761 -0.6505356341475489 SDIK(ub)GQHTETLLAGSLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDIKGQHTETLLAGSLAK 18 1 F5H6X0;F5GXG6;F5GX35;F5H4K7;F5GWD3;Q13889-2;Q13889;H0YFF7 F5H6X0 GTF2H3 General transcription factor IIH subunit 3 1 26568200.0 4674500.0 4959700.0 16934000.0 True False 7091558.25172582 4074602.784687033 13586987.477564149 1.0 0.5745708686374291 1.9159382177051967 22.757671239811522 -6.821407525472529 1.3657215596218897 0.7710140347959313 1.9461270805261275 0.887597552591092 0.187641763189253 0.19166113408587793 0.702044670617973 0.10795540558777614 0.24873765511579643 1.508663816835194e-07 6.821407525472529 1.1751130457301961 SDIK(ub)GQHTETLLAGSLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDIKGQHTETLLAGSLAK 18 1 F5H6X0;F5GXG6;F5GX35;F5H4K7;F5GWD3;Q13889-2;Q13889;H0YFF7 F5H6X0 GTF2H3 General transcription factor IIH subunit 3 1 15122400.0 4101600.0 7035500.0 3985300.0 True False 5618072.361572273 6724648.346712714 3044054.2198299025 1.0 1.196967200477773 0.5418325048020552 22.421643776025785 -6.826094078346202 1.3452898014265435 1.1055617952964836 0.5255707640098352 0.8978337973610011 0.08772431635215372 0.1856786742926361 0.6585709264043219 0.051218901705121556 0.1179050639045881 1.492471070404847e-07 6.826094078346202 -0.5799910312866484 SDIK(ub)GQHTETLLAGSLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDIKGQHTETLLAGSLAK 18 1 F5H6X0;F5GXG6;F5GX35;F5H4K7;F5GWD3;Q13889-2;Q13889;H0YFF7 F5H6X0 GTF2H3 General transcription factor IIH subunit 3 1 13622200.0 3318900.0 6962100.0 3341200.0 True False 2759812.402199615 6924593.785431342 4039829.472036678 1.0 2.5090813346270675 1.463805825648464 21.396138772699118 -10.436785607303124 5.708377490580561 0.999398782134609 1.986443580137767 0.5428503257735793 0.42673193960426414 0.0032669225161042355 0.0003223290888067501 0.4134071927140413 0.13772714128184135 3.6577531475222494e-11 10.436785607303124 0.9870447980031579 SDILK(ub)DPPSEANSIQSANATTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDILKDPPSEANSIQSANATTK 22 1 Q8N488 Q8N488 RYBP RING1 and YY1-binding protein 1 12709700.0 5922500.0 3395100.0 3392100.0 True False 5734493.479312592 4750781.135212608 2503607.2491812864 1.0 0.8284569774734656 0.4365873390933562 22.451234629731584 -6.957364387819255 0.47111431381945595 1.010239070709682 0.23871041434997603 0.9996596020713804 0.0043505112483303516 0.08065645312678578 0.024714843324718246 0.005429643274135894 0.03234063484180645 1.1031526489595644e-07 6.957364387819255 -0.7715286563597059 down SDILK(ub)DPPSEANSIQSANATTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDILKDPPSEANSIQSANATTK 22 1 Q8N488 Q8N488 RYBP RING1 and YY1-binding protein 1 12273700.0 5922500.0 4686400.0 1664800.0 True False 4924821.161236309 4661153.433022433 2012901.982834505 1.0 0.9464614613238694 0.40872590433907113 22.23163990516586 -6.926124479098929 0.7779456837806159 1.0094581661169355 0.3084903971944532 0.9957201861669647 0.017467623262707014 0.09470070198531702 0.08790884128333333 0.015561161155709272 0.04973286258521795 1.1854289274230349e-07 6.926124479098929 -0.7009677689224822 down SDILKDPPSEANSIQSANATTK(ub)TSETNHTSRPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDILKDPPSEANSIQSANATTKTSETNHTSRPR 33 3 Q8N488 Q8N488 RYBP RING1 and YY1-binding protein 1 7241500.0 2114900.0 3670300.0 1456300.0 True False 1758633.055955875 3650527.3654024894 1760805.596829584 1.0 2.0757754740475454 1.0012353576923574 20.746023060901454 -6.645928967056075 2.0232655281097283 1.700315472495979 1.0057577539676823 0.1776437043168705 0.4596170986661256 0.5185733424748274 4.0642425137688525 0.184541483606924 0.508950771613955 2.2598053523984037e-07 6.645928967056075 -0.6945577185282967 SDIPSGTSK(ub)HLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDIPSGTSKHLQK 13 1 Q9Y5T5-2;Q9Y5T5;Q9Y5T5-3;Q9Y5T5-4 Q9Y5T5-2 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 2730960.0 863120.0 1010500.0 857340.0 True False 1131558.6784659708 859737.3388981484 768630.680985991 1.0 0.7597814901333048 0.6792671874763108 20.109879968720737 -13.999999999999998 0.1526937472658667 2.166639879573355 0.5933713397536722 0.9995574971953418 0.002865947605595729 11.968848363419221 0.12319751533112137 4.140022948950927 0.07763132219301495 1.0000000000000041e-14 13.999999999999998 -1.5732685398196828 SDIPSGTSK(ub)HLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDIPSGTSKHLQK 13 1 Q9Y5T5-2;Q9Y5T5;Q9Y5T5-3;Q9Y5T5-4 Q9Y5T5-2 USP16 Ubiquitin carboxyl-terminal hydrolase 16 1 2323530.0 863120.0 881560.0 578850.0 True False 1182238.7889409645 842609.7642709203 442137.5517899631 1.0 0.7127238356184542 0.3739832899460393 20.17309003024363 -6.968948178406932 0.28218343766859855 1.0726913674321377 0.0036627477130339154 0.9999729742555259 0.0013300981186494636 0.07664553353264847 0.010246466938140388 0.00617928346366549 0.031007353290263336 1.0741175723001332e-07 6.968948178406932 -1.0690286197191037 down SDK(ub)PLLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDKPLLVK 8 1 Q9BSC4;Q9BSC4-4;H7C1Z3;Q9BSC4-3 Q9BSC4 NOL10 Nucleolar protein 10 1 1944190.0 497050.0 680700.0 766440.0 True False 651637.3634390468 579142.2133478187 687136.1410116217 1.0 0.888749242817153 1.0544762770894973 19.313709801601078 -6.725846191147709 1.738568286676793 0.9327418825821092 1.0543020572904434 0.5398509141228022 0.04678426987580656 0.3440649886947005 2.035453502353076 0.021343004582074623 0.05320820451775161 1.8799825097062167e-07 6.725846191147709 0.12156017470833413 SDK(ub)PLLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDKPLLVK 8 1 Q9BSC4;Q9BSC4-4;H7C1Z3;Q9BSC4-3 Q9BSC4 NOL10 Nucleolar protein 10 1 2790560.0 643550.0 999010.0 1148000.0 True False 623120.8575114607 1397919.9027683255 847304.360738222 1.0 2.243416964649774 1.3597753156940957 19.249152482986702 -10.136368621827216 4.660446349409977 0.9999243083698264 1.8015961401825056 0.5231805433982717 0.3607451926050065 252014039.2468363 29.519434351074356 204699.16830749225 0.12349267468289346 7.305187682616272e-11 10.136368621827216 0.8016718318126792 SDK(ub)PLLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDKPLLVK 8 1 Q9BSC4;Q9BSC4-4;H7C1Z3;Q9BSC4-3 Q9BSC4 NOL10 Nucleolar protein 10 1 3199950.0 643550.0 1298000.0 1258400.0 True False 535140.3390989671 1291007.416367171 1521525.6218157988 1.0 2.4124651461350894 2.8432273006696525 19.029557758420978 -9.977720382472947 0.29303760593539496 1.1222113499458118e-10 3.0053978233431495 0.9989063023577909 0.026035777284192724 1.3898520384373898 0.13090960576194802 1.3277194334500744 0.15762974069358454 1.0526393903530362e-10 9.977720382472947 3.005397823230928 SDLDSLK(ub)GR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDLDSLKGR 9 1 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8;E9PQR1 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 1 6447800.0 1491600.0 2390300.0 2565900.0 True False 1955502.0446749472 2033676.5573164255 2300405.281850788 1.0 1.039976696958388 1.1763757998182875 20.899107613879238 -6.948528276436877 0.5747774046403894 0.9983356267286593 1.224703091799503 0.9990806382369944 0.0022894279707375035 0.08408222378545076 0.03845059489062116 0.002412498048415039 0.011378398762369698 1.1258271651379968e-07 6.948528276436877 0.2263674650708437 SDLDSLK(ub)GR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDLDSLKGR 9 1 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8;E9PQR1 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 1 10764600.0 2813900.0 2871600.0 5079100.0 True False 2724574.2847509896 4018244.85519617 3748731.340266117 1.0 1.4748156721898351 1.3758961762383106 21.377599395449064 -10.042756919402533 4.673269219969324 0.9999882925964307 1.425355924209518 0.9610190785282818 0.04038371519282408 4969042.608732369 10696468.707671233 427.4245486399386 0.013824420551780247 9.062396937981128e-11 10.042756919402533 0.4253676316130872 SDLDSLK(ub)GR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDLDSLKGR 9 1 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8;E9PQR1 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 1 6078200.0 1491600.0 1973100.0 2613500.0 True False 2043084.82897435 1885921.9178308386 1996245.126722067 1.0 0.9230756800135368 0.9770740296300878 20.96231767540213 -10.06064652735602 4.7384562467239215 1.0000017669892858 0.9500748548218849 0.5326595850412799 0.022044733922334265 4.1152194648272253e-07 8.156066441416159e-08 0.021345477250545666 0.007114907278900537 8.696679648031454e-11 10.06064652735602 -0.04992691216740086 SDLDSLK(ub)GR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDLDSLKGR 9 1 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8;E9PQR1 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 1 12607400.0 2813900.0 6019500.0 3774000.0 True False 2339882.5269063534 5987071.758722804 4563125.950995568 1.0 2.5587061272851743 1.950151727073516 21.15800467088334 -10.19686598638956 6.1846960761152365 0.9999864701474113 2.2544289271793483 0.8499719246872487 0.24844129354068425 4.6350274186690925e-05 6.0190371677323414e-06 0.24055483423012844 0.0801840826994396 6.355270110871887e-11 10.19686598638956 1.254442457031937 SDLDSLK(ub)GR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDLDSLKGR 9 1 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8;E9PQR1 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 1 10133100.0 3567100.0 0.0 6566000.0 True False 4617681.268053108 0.0 5371055.372849311 1.0 0.0 1.1631498713452428 22.13873716494192 -10.676183853934402 4.557741604166076 1.0139877326483862 0.5815749356740557 0.1471543787939661 0.4748539465300696 0.06827464619777017 0.004850739441277094 0.46510002334694844 0.1532584522326364 2.1077356736314272e-11 10.676183853934402 -0.43241279697433044 SDLGNLLK(ub)ALGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDLGNLLKALGR 12 1 O15294;O15294-3;C9JZL3 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 102462000.0 33299000.0 34550000.0 34613000.0 True False 43655311.467974715 29395274.6748452 31031578.79134076 1.0 0.6733493287846407 0.7108316891543736 25.37965385901302 -10.11086144050993 7.684000971210444 1.0000000453191467 0.6920905091626824 0.989008197197757 0.015302109543493885 1.1878673043920574e-08 1.3791484412528149e-09 0.014816206063725357 0.004938734618649445 7.747089253997609e-11 10.11086144050993 -0.3079095361564642 SDLGNLLK(ub)ALGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDLGNLLKALGR 12 1 O15294;O15294-3;C9JZL3 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 177061000.0 65530000.0 53265000.0 58266000.0 True False 63449786.019308485 74533992.27330542 43004386.65746796 1.0 1.1746925710769756 0.6777703969621149 25.919111962881495 -6.811704593922042 1.4073093712874 1.0950164292413678 0.6687300831311835 0.864239464963129 0.07583821980915537 0.20448745891743947 0.7978672535674064 0.04236862964019618 0.09793598057567622 1.5427494706753573e-07 6.811704593922042 -0.42628634611018423 SDLGNLLK(ub)ALGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDLGNLLKALGR 12 1 O15294;O15294-3;C9JZL3 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 180437000.0 77655000.0 55305000.0 47477000.0 True False 117808312.34094943 45435390.65006278 38093150.14009168 1.0 0.38567219703961175 0.32334857688009455 26.81186609580533 -13.999999999999998 0.3233903130747157 7.427442352841088 0.31143823586179187 0.9997009623673752 0.0052803003761276645 18.280380970524327 0.18151460865569888 79.63925752343691 0.020478712528722565 1.0000000000000041e-14 13.999999999999998 -7.116004116979296 SDLGNLLK(ub)ALGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDLGNLLKALGR 12 1 O15294;O15294-3;C9JZL3 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 163751000.0 33299000.0 95238000.0 35214000.0 True False 45610540.171639115 91030070.25004974 26897178.45509502 1.0 1.9958121501628858 0.5897140957742885 25.44286392053591 -6.716404475187448 1.7718186976760992 1.6081201577002737 0.592263821161882 0.49577168305995334 0.41923324887949653 0.362310335473539 2.220778640995373 0.18800167692131645 0.4740396095138614 1.921301513250456e-07 6.716404475187448 -1.0158563365383917 SDLGNLLK(ub)ALGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDLGNLLKALGR 12 1 O15294;O15294-3;C9JZL3 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 158929000.0 65530000.0 60049000.0 33350000.0 True False 54491098.471222565 59725504.118206754 40323330.80702235 1.0 1.096059829840805 0.7399984940350873 25.69951723831577 -6.834863106063468 1.305883316835017 1.0511847347632093 0.7294190732596928 0.9152722330057055 0.04378133363706738 0.17489357363906718 0.581534164994814 0.02630770101488574 0.06055465110775945 1.4626381398792349e-07 6.834863106063468 -0.3217656615035165 SDLGNLLK(ub)ALGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDLGNLLKALGR 12 1 O15294;O15294-3;C9JZL3 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 1 179265000.0 77655000.0 58314000.0 43296000.0 True False 100525928.30889632 55068774.63787429 35416572.25447519 1.0 0.5478066759916788 0.35231280974244833 26.582992417897778 -13.999999999994726 0.11426559343490236 3.1677798351417077 0.014745162342872783 0.9997214784045291 0.004526899915471487 11.989289147015972 0.10324744236811184 5.951798625738556 0.29959621295383215 1.0000000000121439e-14 13.999999999994726 -3.1530346727988348 SDMETHMAAEHCQVTCK(ub)CNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDMETHMAAEHCQVTCKCNK 20 1 O14545;F8VNX8;F8VVF3;O14545-2;S4R2Z9;F8VWK2 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 4370600.0 1667300.0 1427700.0 1275600.0 True False 2283745.8670883174 1364619.4932274527 974329.5518066459 1.0 0.5975356158902596 0.42663659115840075 21.12297068732348 -13.99999999999999 0.11710046166211166 2.923077468775723 0.14290188197852685 0.9997072800756472 0.0041122239128096585 11.975791318241326 0.1049294588069028 5.381301292971228 0.25176816899171267 1.0000000000000246e-14 13.99999999999999 -2.780175586797196 SDMETHMAAEHCQVTCK(ub)CNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDMETHMAAEHCQVTCKCNK 20 1 O14545;F8VNX8;F8VVF3;O14545-2;S4R2Z9;F8VWK2 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 19895100.0 6137100.0 6924800.0 6833200.0 True False 7944596.930326802 6539428.792611582 5589627.714552833 1.0 0.8231290838240906 0.7035759980743168 22.921542595522286 -7.796420632982284 0.06434474082418853 1.6220812659863943 4.4760224135962027e-10 0.9999989220457255 0.00012629152249783696 0.1333033501015649 0.008395040694101139 0.09653939654442194 0.11121597714702432 1.598009537518996e-08 7.796420632982284 -1.6220812655387922 SDNIK(ub)PKSAPWNSFLPPPPPMPGPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDNIKPKSAPWNSFLPPPPPMPGPR 25 2 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;Q16637-4;Q16637-2;B4DP61;A0A0G2JRX5;A0A0G2JRY6;H0YBZ9 A0A1W2PRV5 SMN1;SMN2 Survival motor neuron protein 1 8244800.0 2073300.0 2903900.0 3267600.0 True False 2718116.377865762 2470649.439313541 2929500.097032476 1.0 0.9089564594925368 1.077768457924782 21.374175796649283 -6.7602310988384735 1.6117071268260246 0.9471320915482118 1.0783900883701485 0.6918819771857811 0.03829423377434251 0.28252302240859595 1.4464810241776112 0.01874682191312208 0.04503937346621947 1.7368763479257496e-07 6.7602310988384735 0.13125799682193673 SDNIK(ub)PKSAPWNSFLPPPPPMPGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDNIKPKSAPWNSFLPPPPPMPGPR 25 2 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;Q16637-4;Q16637-2;B4DP61;A0A0G2JRX5;A0A0G2JRY6;H0YBZ9 A0A1W2PRV5 SMN1;SMN2 Survival motor neuron protein 1 8901800.0 2073300.0 3816300.0 3012200.0 True False 2839855.0388257727 3647683.2471835287 2300780.398206318 1.0 1.2844610718904081 0.8101752965382514 21.437385858172174 -6.744304157823887 1.6711232464097123 1.1684075957977784 0.8096388976320432 0.6240068245991188 0.11951360153704219 0.3100941951134254 1.7019527979865694 0.056542806546067505 0.138090922377252 1.8017554407758652e-07 6.744304157823887 -0.3587686981657352 SDNIK(ub)PKSAPWNSFLPPPPPMPGPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDNIKPKSAPWNSFLPPPPPMPGPR 25 2 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;Q16637-4;Q16637-2;B4DP61;A0A0G2JRX5;A0A0G2JRY6;H0YBZ9 A0A1W2PRV5 SMN1;SMN2 Survival motor neuron protein 1 12744400.0 6991000.0 3392500.0 2360900.0 True False 5813326.253812247 3374223.929141477 2854553.2744317534 1.0 0.5804291350289755 0.491036138314068 22.47093244667927 -13.999999999999998 0.21731004157713488 3.5024245939608885 0.44196948384628926 0.9994953444963456 0.004984419648888887 12.92783363606951 0.14769936008124768 13.86326411662767 0.050364945355628 1.0000000000000041e-14 13.999999999999998 -3.0604551101145994 SDNVLLGMEGSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDNVLLGMEGSVK 13 0 Q13177;H7C1X3 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 0 10108200.0 2515100.0 4049100.0 3544000.0 False True 3297320.456263048 3444990.0632681847 3177300.8764484976 1.0 1.0447847301964988 0.9636008748902215 21.652862674165366 -6.756943825539906 1.623812160611584 1.0261126267343663 0.9633468956577503 0.6783804033855245 0.018829386590643947 0.28810877261542084 1.496489896501905 0.009151989682513028 0.022061975231699463 1.7500730397631489e-07 6.756943825539906 -0.06276573107661598 SDNVLLGMEGSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDNVLLGMEGSVK 13 0 Q13177;H7C1X3 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 0 8128200.0 2515100.0 2294100.0 3319000.0 False True 3445000.43802185 2192739.0764257885 2535120.5569506558 1.0 0.6364989252903779 0.735883957798956 21.716072735688257 -10.126937414117434 7.43860504956456 1.0000001005303107 0.6861914415446679 0.9300361796127656 0.040573769619322464 6.763307468044994e-08 7.948428399592405e-09 0.039285396385760465 0.013095127835707711 7.465563363845352e-11 10.126937414117434 -0.3138086589856428 SDPFK(ub)GADPFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDPFKGADPFK 11 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 6475500.0 2684500.0 2421500.0 1369500.0 True False 3519405.4967349786 2060221.6389330719 1227797.277171619 1.0 0.5853891064398177 0.3488649654922317 21.746900316553496 -9.241429050157585 0.1600126979449127 1.5225925874750117 5.611274592122894e-20 0.9997734898434938 0.004050297119881712 0.6791483083633569 0.057305551720706824 0.3392332185190087 0.170533366688329 5.735495585652866e-10 9.241429050157585 -1.5225925874750117 SDPFK(ub)GADPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDPFKGADPFK 11 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 12845000.0 3885100.0 5135000.0 3824900.0 True False 3761769.6270962195 7185432.278671247 2823043.945459601 1.0 1.9101202335502445 0.750456361050148 21.84298006942863 -6.697388056972852 1.8398509215704413 1.5666002128377492 0.7540409095698469 0.40520440358684817 0.3843627795397975 0.40105635815924867 2.6374183649130494 0.16676697541921018 0.43032201740883713 2.0072984212622414e-07 6.697388056972852 -0.8125593032679023 SDPFK(ub)GADPFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDPFKGADPFK 11 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 10436600.0 2684500.0 4941600.0 2810500.0 True False 3677032.1958847153 4723263.772314059 2146717.7840644256 1.0 1.2845315245268376 0.5838180548070814 21.810110378076388 -6.796457100724278 1.4702426623667861 1.1576995319333927 0.5749599375125154 0.8216355920046585 0.12152316097496914 0.22584911151794818 0.9641354083951635 0.06503511690784167 0.15159189566490333 1.597875358165347e-07 6.796457100724278 -0.5827395944208773 SDPFK(ub)GADPFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDPFKGADPFK 11 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;M0R3I1 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 10042600.0 3885100.0 4152600.0 2004900.0 True False 3230632.7891125698 4130229.1195734325 2424115.320389778 1.0 1.278458243070075 0.7503530975600802 21.623385344862907 -6.763419519997394 1.5993951406341875 1.1610522502386011 0.7480762750485249 0.7048595240692432 0.11718566522548836 0.27720336414057356 1.3982586883079429 0.05778691587354243 0.13841758611149063 1.7241715712000804e-07 6.763419519997394 -0.4129759751900762 SDPFLEFFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDPFLEFFR 9 0 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX45;Q5JX52;Q5JX61 Q99829 CPNE1 Copine-1 0 5271300.0 2066700.0 1562500.0 1642100.0 False True 2001093.7397543874 2186414.3983298554 1211984.7480559535 1.0 1.0926096838413049 0.6056611561858724 20.932357320131636 -6.857468218766003 1.1984440921325648 1.049946693633766 0.5831937385403612 0.950490488249726 0.04697888868143002 0.14943243654059726 0.40927504607870696 0.030603693018640257 0.07124757970475726 1.3884549119473775e-07 6.857468218766003 -0.46675295509340486 SDPFLEFFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDPFLEFFR 9 0 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX56;Q5JX45;Q5JX52;Q5JX61 Q99829 CPNE1 Copine-1 0 7794500.0 1439700.0 1940900.0 4413900.0 False True 1971995.9964295875 1855144.6203019996 3371427.7271239855 1.0 0.9407446179712565 1.7096524197960594 20.91122519206584 -6.888296971569802 1.0324353673907138 0.9569829852764005 1.7736130009358035 0.9797845349019326 0.049669342530266614 0.12053453347061795 0.23002161784283656 0.036736737840121325 0.09103878084789796 1.2933111698491523e-07 6.888296971569802 0.8166300156594031 SDPNFK(ub)NR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDPNFKNR 8 1 Q15388 Q15388 TOMM20 Mitochondrial import receptor subunit TOM20 homolog 1 7893400.0 1277400.0 2054100.0 4561900.0 True False 1674683.770359196 1747636.2868190885 4089878.3488347614 1.0 1.0435619653997394 2.442179485597774 20.675457267279047 -6.913539958836801 0.8712739413920746 0.9613921368424688 2.637316760651405 0.9921904326439194 0.059193028889548936 0.10212363403710495 0.12641146017232086 0.04932682824879812 0.139748793272976 1.2202815391561494e-07 6.913539958836801 1.6759246238089363 up SDPNFK(ub)NR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDPNFKNR 8 1 Q15388 Q15388 TOMM20 Mitochondrial import receptor subunit TOM20 homolog 1 11151300.0 1607900.0 3103800.0 6439600.0 True False 1556858.0946199612 4343163.526103175 4752875.576140984 1.0 2.7896977515881876 3.052863708365913 20.570206020152156 -10.251234371864218 0.42022216379752897 1.0918784085699965e-22 3.0701467683525143 0.9991789171811841 0.026134387178549122 1.6165262996459902 0.19422046899037212 1.931292789989229 0.06346319433858909 5.6074528191395574e-11 10.251234371864218 3.0701467683525143 SDPNFK(ub)NR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDPNFKNR 8 1 Q15388 Q15388 TOMM20 Mitochondrial import receptor subunit TOM20 homolog 1 9733800.0 1277400.0 1430300.0 7026100.0 True False 1749689.3004370034 1367104.6166304012 5366679.887071708 1.0 0.7813413594567632 3.0672187832041513 20.738667328801938 -6.883444501667217 1.060450340498793 0.8571898041510455 3.24027788526624 0.9763573610354028 0.15836071709115276 0.1246205600442278 0.25424489128306893 0.11465899065602701 0.27985621011006895 1.3078426569761554e-07 6.883444501667217 2.3830880811151944 up SDPNFK(ub)NR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDPNFKNR 8 1 Q15388 Q15388 TOMM20 Mitochondrial import receptor subunit TOM20 homolog 1 10656600.0 1607900.0 3042900.0 6005800.0 True False 1337040.0920475922 3026507.2937316378 7261585.012318288 1.0 2.263587540667336 5.4310899542269 20.350611295586432 -6.9554037493773695 0.4959860143993525 0.9342970810795167 6.896068589132368 0.9995599429864855 0.039098261957279876 0.08138571348641889 0.027523388991133477 0.04620585953599281 0.26126197077403107 1.108144130880305e-07 6.9554037493773695 5.961771508052852 SDPVLHIDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDPVLHIDLR 10 0 H3BRQ0;Q96CD2-2;Q96CD2 H3BRQ0 PPCDC Phosphopantothenoylcysteine decarboxylase 0 3918690.0 0.0 1919290.0 1999400.0 False True 0.0 2685672.5059651267 1475697.1592857135 0.0 SDPYLEFHK(ub)QTSDGNWLMVHR ddPTM_RPMI8226_Bortezomib_1h_R1 2 SDPYLEFHKQTSDGNWLMVHR 21 1 O75131;A0A087WYQ3 O75131 CPNE3 Copine-3 1 171375600.0 60635000.0 61475000.0 49265600.0 True False 79493072.19017532 52303169.62767322 44168068.30100482 1.0 0.6579588407722586 0.5556216042995458 26.2443257994213 -13.999999999880762 0.16909851551253427 2.7208903768936166 0.46447663287504076 0.9995154267101829 0.0041827104363129025 12.08290023558425 0.1302009815172019 6.820084352894329 0.0841242440165061 1.0000000002745555e-14 13.999999999880762 -2.256413744018576 SDPYLEFHK(ub)QTSDGNWLMVHR ddPTM_RPMI8226_Bortezomib_2h_R1 2 SDPYLEFHKQTSDGNWLMVHR 21 1 O75131;A0A087WYQ3 O75131 CPNE3 Copine-3 1 296490300.0 84909500.0 78429200.0 133151600.0 True False 82214094.39961047 109746388.56287478 98275201.49762315 1.0 1.3348853303600308 1.1953571004497834 26.29288240820787 -10.150982445930168 4.228050865553294 0.9999369407318925 1.2651212154305016 0.8280005357996784 0.056962161496551075 39850734.08754211 3.397044017049951 26456.88674244232 0.019499662959816418 7.063461040115035e-11 10.150982445930168 0.26518427469860906 SDPYLEFHK(ub)QTSDGNWLMVHR ddPTM_RPMI8226_Bortezomib_8h_R1 2 SDPYLEFHKQTSDGNWLMVHR 21 1 O75131;A0A087WYQ3 O75131 CPNE3 Copine-3 1 629679600.0 219162000.0 210534000.0 199983600.0 True False 332484776.8883807 172962562.79035002 160456753.8040742 1.0 0.5202119760460965 0.48259879837428327 28.30871304614757 -13.999999999999998 0.3609785774813965 7.316061523197643 0.47813308394005316 0.9997750565180312 0.003532663817289591 21.80267816427159 0.19425103681320102 106.13419630610316 0.010819181496291488 1.0000000000000041e-14 13.999999999999998 -6.83792843925759 SDPYLEFHK(ub)QTSDGNWLMVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SDPYLEFHKQTSDGNWLMVHR 21 1 O75131;A0A087WYQ3 O75131 CPNE3 Copine-3 1 218687000.0 60635000.0 80760000.0 77292000.0 True False 83053398.09926242 77191756.16239345 59037221.478707574 1.0 0.9294232136069455 0.7108345092412525 26.307535860944192 -6.950732526077921 0.5507510306184599 1.003009648730178 0.6269660079832371 0.9992574670485626 0.0033543577350669714 0.0831930787404992 0.03475645076193372 0.0036372367709086024 0.018136337093414282 1.1201275368622025e-07 6.950732526077921 -0.37604364074694097 SDPYLEFHK(ub)QTSDGNWLMVHR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SDPYLEFHKQTSDGNWLMVHR 21 1 O75131;A0A087WYQ3 O75131 CPNE3 Copine-3 1 255960300.0 84909500.0 98030000.0 73020800.0 True False 70606011.3786399 97501892.93256858 88289111.66996758 1.0 1.3809290601290836 1.250447517797008 26.073287683642146 -10.150901783774819 5.055963201376308 0.9999839213985464 1.3156882889635404 0.8864245967084604 0.05326886659587718 9.654936626071679e-06 1.6215155039704555e-06 0.0515799835282957 0.017192452766185005 7.064773069001814e-11 10.150901783774819 0.315704367564994 SDPYLEFHK(ub)QTSDGNWLMVHR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SDPYLEFHKQTSDGNWLMVHR 21 1 O75131;A0A087WYQ3 O75131 CPNE3 Copine-3 1 540457500.0 219162000.0 156747500.0 164548000.0 True False 283709529.3288825 148024363.83287373 134601952.40505767 1.0 0.5217461823824766 0.474435781989628 28.07983936824002 -13.999999999999998 0.3270511167238877 6.114616069832669 0.4657650824518303 0.9997086881219807 0.004051721927605813 18.577290027812897 0.1827200444682206 65.2566815350742 0.015329811556864668 1.0000000000000041e-14 13.999999999999998 -5.648850987380839 SDQDYILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDQDYILK 8 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 19392500.0 1368400.0 11185000.0 6839100.0 False True 1793985.6516044508 9516241.598788524 6131455.537279601 1.0 5.304524922079324 3.41778404514882 20.774736920873497 -9.43057863898698 10.463381795737282 1.0000000026835059 4.36115448560504 0.8088491025761723 0.7702587375551694 0.0 0.0 0.7457998157054795 0.24859993856849313 3.710405380016489e-10 9.43057863898698 3.361154482921534 SDQDYILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDQDYILK 8 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 17378900.0 5595600.0 2469500.0 9313800.0 False True 5417970.74087659 3455584.228272369 6874236.3719892455 1.0 0.6378004595339102 1.2687843291817116 22.36932117177768 -6.751000888582477 1.6459048374757121 0.7872870899958371 1.270155229773484 0.6534048471375141 0.15220698260897295 0.2982807803545545 1.5900865262253803 0.0730396897393114 0.17715108733533214 1.7741858508369716e-07 6.751000888582477 0.48286813977764687 SDQDYILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDQDYILK 8 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 18665500.0 1368400.0 7718700.0 9578400.0 False True 1874334.4596195372 7377662.311672438 7316179.193340208 1.0 3.9361503886398146 3.9033477487391908 20.83794698239639 -10.146123833240432 4.604368802368414 0.9996583975132582 3.9197490687359213 0.9999053442982552 0.013391621819261103 4682147.876606781 11.404518193688025 16967.40804900896 0.004584308321478303 7.142926260839018e-11 10.146123833240432 2.9200906712226633 SDQDYILK(ub)EGDLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDQDYILKEGDLVK 14 1 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 8855700.0 3534800.0 2831800.0 2489100.0 True False 4634157.03105189 2409306.478269946 2231551.809133166 1.0 0.5199017776320511 0.4815442796133808 22.14387550089882 -13.999999999999998 0.35820321764204205 7.211855822545713 0.47680634075584666 0.9997700217294714 0.0035771506938015265 21.504257004975752 0.19328192650800852 102.03345126212508 0.011134010380771078 1.0000000000000041e-14 13.999999999999998 -6.735049481789867 SDQDYILK(ub)EGDLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDQDYILKEGDLVK 14 1 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 10560400.0 2443400.0 3539900.0 4577100.0 True False 2365835.6044495404 4953400.53033463 3378220.199943307 1.0 2.0937213562170305 1.4279184037934531 21.173918397488162 -10.171791448654387 5.744769521454498 0.9999960639315464 1.7608198796659036 0.6351761748507505 0.27181291716643097 4.625503033671066e-05 6.668436807470278e-06 0.26318631337758847 0.08772724178104752 6.732999021395269e-11 10.171791448654387 0.7608238157343572 SDQDYILK(ub)EGDLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDQDYILKEGDLVK 14 1 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 9552000.0 3534800.0 2693900.0 3323300.0 True False 4841711.084378203 2574874.590463988 2538404.9855119395 1.0 0.53181087132023 0.5242784918955845 22.20708556242171 SDQDYILK(ub)EGDLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDQDYILKEGDLVK 14 1 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 8400900.0 2443400.0 3810600.0 2146900.0 True False 2031795.3609733747 3790071.5414551245 2595806.8638559566 1.0 1.8653805468083213 1.2775926718389494 20.95432367292244 -10.13041332448381 5.872013685789388 0.9999955251541083 1.5714866093236557 0.5576011138030671 0.23996339511170509 1.405791017789e-05 2.081939958264586e-06 0.23234537503664293 0.07744785274724149 7.406050609950866e-11 10.13041332448381 0.5714910841695474 SDQDYILK(ub)EGDLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDQDYILKEGDLVK 14 1 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3;H0YIN7;F8VZ69 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 31317500.0 4700400.0 6768100.0 19849000.0 True False 6084760.458735908 6391449.285361947 16236685.66793878 1.0 1.05040277734939 2.668418219262473 22.536769038212874 -6.913540513593571 0.8712659898226106 0.9553366228397665 2.894172042146474 0.9921907114552906 0.06847744121997507 0.10212336559296228 0.12640812231408152 0.05706388492667832 0.1616703911643262 1.2202799804004198e-07 6.913540513593571 1.9388354193067077 up SDQLQQAVQSQGFINYCQK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDQLQQAVQSQGFINYCQKK 20 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3;O94979-5;H0Y8V7 D6REX3 SEC31A Protein transport protein Sec31A 1 9941200.0 3458400.0 3728600.0 2754200.0 True False 2875812.8330974523 3708513.291730845 3330090.486018022 1.0 1.2895530783679394 1.157964957834645 21.45553835304681 -10.146973095774214 4.131547859565755 0.9999373785755789 1.223759018027165 0.7940426200060908 0.05372062543313538 7489797.729234631 9197376.557524685 3558.437858046106 0.01839000048396914 7.128971922186966e-11 10.146973095774214 0.22382163945158606 SDQLQQAVQSQGFINYCQKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDQLQQAVQSQGFINYCQKK 20 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3;O94979-5;H0Y8V7 D6REX3 SEC31A Protein transport protein Sec31A 1 6775200.0 3695200.0 3080000.0 0.0 True False 4844442.984367706 2620476.00574597 0.0 1.0 0.5409241091704154 0.0 22.207899362954635 -7.8078205221744 0.6192045179129767 1.0048093399786957 2.940421305132431e-19 0.9881115868036628 0.04456261576683921 0.11656999523316869 0.15609396287170135 0.04346275802764905 0.0778263887828997 1.5566087874636907e-08 7.8078205221744 -1.0048093399786957 down SDQNLQTALELTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDQNLQTALELTR 13 0 O95373 O95373 IPO7 Importin-7 0 6257000.0 1203200.0 2195800.0 2858000.0 False True 1577406.8518053754 1868195.1991613628 2562281.5758718387 1.0 1.1843458122571067 1.624363158394585 20.589123383783235 -6.956445839199227 0.48292481279212335 0.9897236428205964 1.8374217826733317 0.9996148274863654 0.005140427929577601 0.08099602874901257 0.02601463572307279 0.006241395895691301 0.03629451703891248 1.1054883260726887e-07 6.956445839199227 0.8476981398527352 SDQNLQTALELTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDQNLQTALELTR 13 0 O95373 O95373 IPO7 Importin-7 0 5161800.0 1203200.0 1734100.0 2224500.0 False True 1648055.5552574012 1657481.7280981494 1699118.9150155906 1.0 1.0057195722624024 1.0309840039040516 20.652333445306127 -6.942604118484036 0.6348880449268582 0.999724152785836 1.0383524617763464 0.9984851389830798 0.0005239231538532527 0.08659892030929216 0.049351222316569084 0.0005206835815432972 0.002150762301520759 1.141289657130309e-07 6.942604118484036 0.038628308990510396 SDQSYVISFVVPNQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDQSYVISFVVPNQK 15 0 O60488-2;O60488 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 0 7708100.0 1955600.0 2616800.0 3135700.0 False True 2563810.538057342 2226383.6402065097 2811247.8437583377 1.0 0.8683885205860381 1.0965115409379995 21.289858222113736 -6.750244786774376 1.648769591589727 0.9226355984721679 1.0969784463881629 0.6501156794333032 0.05530477034058855 0.29960683471273225 1.6025033738855279 0.026495909826209862 0.064312646539961 1.777277378824297e-07 6.750244786774376 0.17434284791599497 SDQSYVISFVVPNQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDQSYVISFVVPNQK 15 0 O60488-2;O60488 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 0 6977500.0 1955600.0 1746300.0 3275600.0 False True 2678638.168102872 1669142.6917581432 2501970.7430995996 1.0 0.6231310789319121 0.9340458046528934 21.353068283636627 -9.98691503252151 6.738782800863029 1.0000000329792469 0.7785884417924017 0.40340226311258076 0.12693040525563515 6.289763469442732e-08 9.511699716768792e-09 0.12289985473407887 0.04096661214020225 1.0305877299002145e-10 9.98691503252151 -0.22141159118684517 SDQSYVISFVVPNQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDQSYVISFVVPNQKR 16 1 O60488-2;O60488 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 11104800.0 4015500.0 4475300.0 2614000.0 True False 5264359.3861573115 3807602.684582767 2343528.35525857 1.0 0.723279397412513 0.4451687628737701 22.327826551354892 -6.971063093201311 0.23139085359927827 1.1111567138605152 0.04933168265155701 0.9999895279409443 0.00073297354868703 0.07595922750680562 0.007784794156299458 0.007073267476156807 0.02754786260151698 1.0688995809210096e-07 6.971063093201311 -1.061825031208958 down SDQSYVISFVVPNQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDQSYVISFVVPNQKR 16 1 O60488-2;O60488 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 17869200.0 7382000.0 6562300.0 3924900.0 True False 7147662.4507025005 9182660.61194242 2896850.945523907 1.0 1.2847082070922238 0.40528647869195233 22.7690400738496 -6.8195454202209795 1.3737739650360221 1.1535311882569719 0.386265337334125 0.883337858808185 0.12514103545501087 0.1940810345090863 0.7198338909440941 0.0715838577536089 0.16501492081420055 1.5151463354634163e-07 6.8195454202209795 -0.7672658509228469 down SDQSYVISFVVPNQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDQSYVISFVVPNQKR 16 1 O60488-2;O60488 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 19176700.0 7382000.0 8947200.0 2847500.0 True False 6138460.078049209 8898999.65771985 3442899.0846475563 1.0 1.4497120685922806 0.5608734179047887 22.549445349283875 -6.7691788020089865 1.5778610444923933 1.258214731830484 0.5560593857671962 0.7273216857134117 0.18948850626525102 0.26775590510406544 1.315511887527649 0.0946718469299581 0.2255042734904914 1.7014578623337315e-07 6.7691788020089865 -0.7021553460632878 SDQWK(ub)PLNLEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDQWKPLNLEEK 12 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 21313920.0 5942800.0 6171420.0 9199700.0 True False 5754149.0669242535 8635700.189530136 6790022.584915874 1.0 1.5007779758730075 1.180022016451743 22.45617116532781 -10.135764880144809 4.791330647053461 0.9999753940491349 1.3403999961608621 0.6002636271178534 0.13094807209795187 3.443026575297605e-05 6.210647682702974e-06 0.1267990836229864 0.04226330853662373 7.315350172664737e-11 10.135764880144809 0.3404246021117272 SDQWK(ub)PLNLEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDQWKPLNLEEK 12 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 124107000.0 17685500.0 34912500.0 71509000.0 True False 26830196.48323819 28682091.60239249 57375214.80649195 1.0 1.0690227937880086 2.1384567512331247 24.67735428401144 -6.920034783955802 0.8244723738984179 0.9764334490228479 2.311048686984194 0.9941905308071141 0.03972329511096747 0.09815119497409898 0.10550932200693688 0.034232012273338316 0.10257470997276495 1.2021681454863794e-07 6.920034783955802 1.334615237961346 up SDQWK(ub)PLNLEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDQWKPLNLEEK 12 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 17498600.0 4456600.0 7466100.0 5575900.0 True False 6104325.455086542 7136223.014908933 4258987.259265191 1.0 1.1690436670545707 0.6976998999482098 22.541400451536344 -6.809710922827867 1.4156780415914318 1.0921604124217867 0.6895033880133976 0.8590786601001288 0.07319142507627358 0.20720182065191806 0.8184910081283666 0.040652285373858864 0.09405253574257078 1.549847892827641e-07 6.809710922827867 -0.40265702440838913 SDQWK(ub)PLNLEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDQWKPLNLEEK 12 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 14638620.0 5942800.0 1190200.0 7505620.0 True False 4941701.510678793 1183788.1563637974 9075010.439934123 1.0 0.23955072029455537 1.8364141218006462 22.236576440762086 -6.777208735942042 1.546799497182382 0.5678597067950414 1.8479648648432172 0.7573915885984578 0.3212246102300041 0.25492414268176916 1.2045284522646895 0.16360148623005977 0.38693270522295115 1.6702876272240617e-07 6.777208735942042 1.2801051580481757 SDQWK(ub)PLNLEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDQWKPLNLEEK 12 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 128176700.0 17685500.0 21476200.0 89015000.0 True False 22894228.383323494 20281030.59090293 72815183.37102975 1.0 0.8858577913757487 3.1805039310287233 24.44848060610389 -6.895197473723655 0.9911392658958278 0.8916240609205163 3.3991854871158 0.9840214376500132 0.13346382909106014 0.11502690458973651 0.1980295087041085 0.1018366224239435 0.2591184898426203 1.27292415072885e-07 6.895197473723655 2.5075614261952834 up SDQWKPLNLEEK(ub)KR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDQWKPLNLEEKKR 14 3 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 41228000.0 5833000.0 0.0 35395000.0 True False 8849087.44942063 0.0 28399162.73582036 1.0 0.0 3.2092758601543396 23.07709725614965 -6.822988493554808 1.3588673967858629 0.46254653021582354 3.2839523894939147 0.8911179271257214 0.4424364608544351 0.18962987788732505 0.6872012977236608 0.2558009347776126 0.5891708571163707 1.5031817917163974e-07 6.822988493554808 2.8214058592780913 SDQWKPLNLEEK(ub)KR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDQWKPLNLEEKKR 14 3 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 4922300.0 2115300.0 1756500.0 1050500.0 True False 2897383.5738330944 1678892.022031254 802393.5357266252 1.0 0.579451073442155 0.27693728333839435 21.466319259605683 -8.06070493654475 0.24384286560574323 1.1912567308980744 1.1890007981033991e-11 0.9996168125594921 0.005803982824206817 0.09472893611392669 0.04673447376887962 0.07544718000398623 0.09927391600401603 8.695510091735278e-09 8.06070493654475 -1.1912567308861843 down SDQWKPLNLEEKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDQWKPLNLEEKK 13 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 16793500.0 4380200.0 6501000.0 5912300.0 True False 3642330.3757614675 6465977.822652534 7148534.59461343 1.0 1.775231007511435 1.9626266310669178 21.796430356508704 -10.947740833647293 0.27328931958155034 1.7916449633034124e-13 2.0356418563123344 0.9992100684917136 0.011711653145464535 2.831223141179559 0.14180187465051292 1.8728571907737324 0.07606769277069195 1.1278703149111711e-11 10.947740833647293 2.0356418563121554 SDSEDICLFTK(ub)DEPNSTPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDSEDICLFTKDEPNSTPEK 20 1 O76021;J3QSV6;I3L3U9;I3L3C4;I3L234 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 9842100.0 2588400.0 3990600.0 3263100.0 True False 3393417.4661012557 3395218.0352369626 2925465.7138654287 1.0 1.0005306064325106 0.8621001521591556 21.694307493987207 -6.9060370357487715 0.9223091252469678 1.004841542877058 0.8456481569524373 0.9893379235647178 0.006725357865693594 0.1070970151578376 0.15341769706826497 0.005400451052352815 0.01452830956232994 1.2415464265275542e-07 6.9060370357487715 -0.15919338592462073 SDSEDICLFTK(ub)DEPNSTPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDSEDICLFTKDEPNSTPEK 20 1 O76021;J3QSV6;I3L3U9;I3L3C4;I3L234 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 7509500.0 3140000.0 2041200.0 2328300.0 True False 3040322.4187490987 2856261.804717378 1718448.382497215 1.0 0.9394601661663733 0.5652191267280949 21.53579289538298 -6.935206978142827 0.7027405570896198 1.004743730683793 0.47710080553295536 0.9974662303584334 0.009678879257554106 0.09002298408727774 0.06508698827933948 0.009109113597429861 0.03294707182746504 1.1608952169817123e-07 6.935206978142827 -0.5276429251508377 SDSEDICLFTK(ub)DEPNSTPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDSEDICLFTKDEPNSTPEK 20 1 O76021;J3QSV6;I3L3U9;I3L3C4;I3L234 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 8073600.0 2588400.0 2637000.0 2848200.0 True False 3545401.4288798654 2520488.6206071223 2175513.8205202958 1.0 0.7109176975210522 0.6136156551410958 21.7575175555101 -13.999999999999998 0.15207802351103084 2.4024961913116587 0.5090801236903832 0.9995594513243087 0.003444116982750108 11.966122410525008 0.12292007914962214 4.956524427701638 0.09441745793210818 1.0000000000000041e-14 13.999999999999998 -1.8934160676212755 SDSEDICLFTK(ub)DEPNSTPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDSEDICLFTKDEPNSTPEK 20 1 O76021;J3QSV6;I3L3U9;I3L3C4;I3L234 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 1 12222900.0 4967800.0 3592300.0 3662800.0 True False 6430915.029977927 3392385.347114515 2996207.9835017445 1.0 0.5275120774105702 0.46590694629532814 22.61659259696921 -13.999999999999998 0.2871825098278988 5.007482757538669 0.44863763641738696 0.9996211609200816 0.004643720076802728 15.800339003934889 0.16988377626271864 37.3471732025768 0.023566642137282073 1.0000000000000041e-14 13.999999999999998 -4.558845121121282 SDSFENPVLQQHFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDSFENPVLQQHFR 14 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 18399500.0 4937700.0 2937800.0 10524000.0 False True 4780955.416260333 4110878.8604246145 7767448.6867674505 1.0 0.8598446340752843 1.6246645305141028 22.18886752153979 -6.859424762833699 1.1886488723340005 0.9240692802999995 1.6612928133203224 0.9529305853705042 0.07212997203137438 0.14740274299545242 0.3960687428248739 0.04733975271433688 0.1104338137580803 1.3822138398555348e-07 6.859424762833699 0.737223533020323 SDSGK(ub)PYYYNSQTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDSGKPYYYNSQTK 14 1 O75400-2;O75400;O75400-3;F5H578;H7C2N3;H0YG38 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 11864200.0 4581800.0 4810900.0 2471500.0 True False 5931230.420780388 4543169.185879018 2021712.3597315087 1.0 0.765974150989275 0.3408588465301111 22.499899989073995 -6.961882043361806 0.40804409923337703 1.0213934774233873 0.06971320393003502 0.9998337562403151 0.0035178286669890683 0.07903555068807869 0.01869678779084467 0.005471603936132301 0.035516743736050724 1.091736817577137e-07 6.961882043361806 -0.9516802734933523 down SDSK(ub)FAYTGTEMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 SDSKFAYTGTEMR 13 1 A0A087WZR3;P46736-2;P46736-3;P46736-5;H9KVA9;A0A0D9SF50;P46736 A0A087WZR3;H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 7218080.0 1964680.0 2822500.0 2430900.0 True False 2575714.505988183 2401394.002018828 2179373.7868393473 1.0 0.9323214962046128 0.8461239713378956 21.296541262302796 -6.967833110305367 0.30554615437653454 1.0139976053230344 0.7617254444696396 0.9999601963286814 0.0003972436146404079 0.07701229709465181 0.011533805683996682 0.0013921656634760288 0.007686467132654018 1.0768789547217068e-07 6.967833110305367 -0.25227216085339477 SDSK(ub)FAYTGTEMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDSKFAYTGTEMR 13 1 A0A087WZR3;P46736-2;P46736-3;P46736-5;H9KVA9;A0A0D9SF50;P46736 A0A087WZR3;H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 7225000.0 1722800.0 2011300.0 3490900.0 True False 1668110.6570130405 2814422.578790939 2576528.5652448246 1.0 1.6871917740939995 1.5445789249128228 20.669783564958486 -10.119034865548992 4.6985906153422 0.9999559267670186 1.615885349510412 0.9613405136459952 0.0582214519052788 2.7257673179066222e-05 5.110656655162362e-06 0.05637675511354378 0.01879089279766429 7.602652397175126e-11 10.119034865548992 0.6159294227433934 SDSK(ub)FAYTGTEMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 SDSKFAYTGTEMR 13 1 A0A087WZR3;P46736-2;P46736-3;P46736-5;H9KVA9;A0A0D9SF50;P46736 A0A087WZR3;H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 43605100.0 5216900.0 12054900.0 26333300.0 True False 7914418.706477356 9903608.909636408 21128511.71270461 1.0 1.2513374989285124 2.669622684406691 22.916051961369607 -6.9371480627149325 0.6855919243280894 0.9830239210758831 3.0219884759379876 0.9977658468768701 0.034742256053804155 0.08909231634183254 0.06071945761385781 0.033128308381122594 0.12368078872864642 1.1557181594939703e-07 6.9371480627149325 2.0389645548621047 up SDSK(ub)FAYTGTEMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDSKFAYTGTEMR 13 1 A0A087WZR3;P46736-2;P46736-3;P46736-5;H9KVA9;A0A0D9SF50;P46736 A0A087WZR3;H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 3582890.0 969490.0 1105100.0 1508300.0 True False 1327936.652482128 1056273.0279229945 1152070.6044135822 1.0 0.7954242590929692 0.8675644295683655 20.340754895730623 -10.634073534690252 9.098623197760293 1.0000789200684745 0.8314943454459084 0.879149273329489 0.029451101270352213 4.7170333996363875e-05 1.8970609961402746e-06 0.02852918418034285 0.009505302062295187 2.3223435441314276e-11 10.634073534690252 -0.16858457462256615 SDSK(ub)FAYTGTEMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDSKFAYTGTEMR 13 1 A0A087WZR3;P46736-2;P46736-3;P46736-5;H9KVA9;A0A0D9SF50;P46736 A0A087WZR3;H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 7449700.0 1722800.0 2746600.0 2980300.0 True False 1432584.5329806523 2731803.520642585 3603466.950649733 1.0 1.9069056364574608 2.5153607816442896 20.450188840392762 -8.206876391671345 0.15220227876543674 1.3888495723078378e-10 3.6670434214682417 0.9999239942530702 0.005428165227286493 0.08722247755725729 0.0313100957394249 0.3269538821670358 0.34637390826425646 6.210457703143123e-09 8.206876391671345 3.667043421329357 SDSK(ub)FAYTGTEMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SDSKFAYTGTEMR 13 1 A0A087WZR3;P46736-2;P46736-3;P46736-5;H9KVA9;A0A0D9SF50;P46736 A0A087WZR3;H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 53967200.0 5216900.0 13325300.0 35425000.0 True False 6753379.890473004 12583735.34111988 28978013.491195124 1.0 1.8633240755302038 4.290890481679317 22.687178283462057 -6.952896788595903 0.5260817848488364 0.9606042641101394 5.303076099589395 0.999409441957412 0.03385604243971541 0.08234298041772703 0.031306634172514086 0.0379936044788338 0.20064982667435388 1.1145593805452462e-07 6.952896788595903 4.342471835479256 SDSYVLLEHSVK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDSYVLLEHSVKK 13 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5H0N1 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 12532600.0 2843800.0 4014200.0 5674600.0 True False 3681355.1596785765 3790806.2412346024 4641881.026312934 1.0 1.0297311932178752 1.2609163813247029 21.811805510132775 -6.930627549541151 0.7416127346357811 0.9965651472798273 1.309146653303708 0.9966603800325163 0.006739564319542873 0.09231289282175166 0.07609046248245342 0.006163194183608749 0.020846478989128142 1.1732010701581625e-07 6.930627549541151 0.3125815060238807 SDSYVLLEHSVKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDSYVLLEHSVKK 13 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5H0N1 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 6480300.0 1655100.0 1166300.0 3658900.0 True False 1602559.7564559341 1632009.6721741527 2700524.325352857 1.0 1.0183767972455187 1.685131749049455 20.611946722570877 -6.912804359362911 0.8764224206111567 0.9811410765012447 1.77667359354941 0.9919373273880274 0.028619621662613753 0.10259306927730295 0.12892573007752967 0.023761025959375508 0.06693821923907385 1.2223501795055635e-07 6.912804359362911 0.7955325170481653 SDSYVLLEHSVKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDSYVLLEHSVKK 13 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5H0N1 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 18577900.0 2882500.0 5988400.0 9707000.0 True False 4372963.238977364 4919723.232417247 7788407.195270762 1.0 1.125031920818924 1.7810365122328615 22.06017978987502 -6.938737279063263 0.6712130631650404 0.9924511436993119 1.951553869068999 0.9979937266449331 0.015342788378774576 0.08834751373904548 0.05726966013783681 0.014795831934156557 0.0567823434765311 1.151496761648683e-07 6.938737279063263 0.9591027253696872 SDSYVLLEHSVKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDSYVLLEHSVKK 13 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5H0N1 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 7369910.0 2186910.0 1025300.0 4157700.0 True False 2995469.726020577 979998.8557863047 3175736.890519355 1.0 0.32716032723462507 1.0601799320263068 21.51435082217601 -12.087114540264366 18.8724123868871 0.929828900035116 0.7243031166678164 0.0 0.3398746836571862 0.0 0.0 0.0 0.09901090619459113 8.182489557541794e-13 12.087114540264366 -0.20552578336729954 SDSYVLLEHSVKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDSYVLLEHSVKK 13 1 F5H0F9;Q9UJX4-3;Q9UJX4;H0YFB5;F5H0N1 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 1 7391900.0 1655100.0 2535000.0 3201800.0 True False 1376288.98336213 2521343.4518418973 3871281.576549447 1.0 1.8319869462898113 2.812840634015911 20.392351998005154 -6.9689505481022325 0.28212696011218774 0.7893726770219298 3.8854308600246603 0.9999730008743747 0.003849868681882632 0.07664469747854592 0.010243482663534968 0.01789840930196896 0.0897908687004872 1.0741117114740693e-07 6.9689505481022325 3.0960581830027305 SDVEAIFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDVEAIFSK 9 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 27948500.0 5704500.0 11956000.0 10288000.0 False True 7478654.742456584 10172211.40412298 9223496.449464478 1.0 1.360165932834816 1.2333095679764927 22.834347351344707 -10.116469494415792 4.294384852824964 0.9999562488848875 1.2967377504025066 0.8794538728704653 0.051788894235748166 7562326.918058661 8907453.320847087 2700.2024409036685 0.017728715587827723 7.647694052580038e-11 10.116469494415792 0.29678150151761906 SDVEAIFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDVEAIFSK 9 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 22204200.0 7339000.0 3591200.0 11274000.0 False True 7106027.462165488 5025184.887860603 8321001.187249739 1.0 0.7071721738504554 1.170977910168954 22.76061183348633 -6.736085800474161 1.7012277772141409 0.8249825043841025 1.1710141409747508 0.5871768803677093 0.12305004156758137 0.3249349448260693 1.844973525979609 0.057259486739057 0.14110699182374456 1.8361755473592358e-07 6.736085800474161 0.3460316365906483 SDVEAIFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDVEAIFSK 9 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 23522900.0 5704500.0 8196400.0 9622000.0 False True 7813607.808316027 7834255.94612979 7349481.771310402 1.0 1.0026425869227513 0.940600290110331 22.8975574128676 -6.896952173819754 0.980346268587671 1.002799603001965 0.934476653636853 0.9849876141045193 0.0035096612649264535 0.11368325944035346 0.19034717136404758 0.002699705891241424 0.006922607641356754 1.2677914722482354e-07 6.896952173819754 -0.06832294936511207 SDVEAIFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDVEAIFSK 9 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 12445300.0 7339000.0 3093700.0 2012600.0 False True 6102703.672826216 3077033.6240486316 2433425.354789002 1.0 0.50420826391258 0.398745455333908 22.541017108920606 -13.999999999999998 0.2175374231247024 3.959928458646373 0.3409845957704235 0.9994955483896346 0.005887578143765694 12.93380825537294 0.14777497567427622 16.424480486507818 0.05932848445388205 1.0000000000000041e-14 13.999999999999998 -3.6189438628759496 SDVEAIFSK(ub)YGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDVEAIFSKYGK 12 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 48952000.0 15839000.0 17517000.0 15596000.0 True False 20765082.38509417 14903531.8807312 13982275.527395815 1.0 0.7177208163368244 0.6733551674917858 24.307656259852454 -13.999999999456303 0.2604665114060282 3.0714531471480315 0.6572121205702725 0.9995632862516486 0.003023120008351805 14.437789405689372 0.16150403154104664 15.746083073225337 0.019348488985291436 1.0000000012519077e-14 13.999999999456303 -2.414241026577759 SDVEAIFSK(ub)YGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDVEAIFSKYGK 12 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 60765000.0 16327000.0 19154000.0 25284000.0 True False 15808708.321947964 26802292.08679048 18661361.896258883 1.0 1.6954131571634865 1.1804482387944655 23.914216158811794 -10.638348189697332 4.98753196346367 0.9931189387156594 1.4379306979789797 0.4909024697641601 0.2102335475730282 0.016236921857180397 0.0011773573767702042 0.20546909626643817 0.06785258571370181 2.299597407180005e-11 10.638348189697332 0.4448117592633203 SDVEAIFSK(ub)YGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDVEAIFSKYGK 12 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 109585000.0 24989000.0 29174000.0 55422000.0 True False 37910139.94060899 23967671.76249758 44467817.40767452 1.0 0.632223246868673 1.1729795109524512 25.176080446260848 -6.72357611232886 1.7463808666648144 0.7771045782170075 1.1723133442892353 0.5293158677302028 0.15469848188237412 0.3484414616690846 2.0786834487637704 0.07028304725098744 0.17570340763398073 1.8898349989148235e-07 6.72357611232886 0.39520876607222777 SDVEAIFSK(ub)YGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDVEAIFSKYGK 12 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 60733000.0 15839000.0 24598000.0 20296000.0 True False 21695106.3328806 23511179.02529163 15502502.809240913 1.0 1.0837088633973935 0.7145621953346077 24.370866321375345 -6.847111878862101 1.2489618456886435 1.0445826530733626 0.7006082862684277 0.9359949870799739 0.03997944150398868 0.16066216265062658 0.4837321700000366 0.025065637566418494 0.05790592247405061 1.4219624273415436e-07 6.847111878862101 -0.3439743668049349 SDVEAIFSK(ub)YGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDVEAIFSKYGK 12 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 54643000.0 16327000.0 24120000.0 14196000.0 True False 13576623.908738764 23990060.772554833 17164317.9651121 1.0 1.7670122508964345 1.2642552434603476 23.69462143424607 -10.264647561048205 6.717684289674524 0.9999940786282013 1.5156337471783903 0.583768178338713 0.20524968880451025 1.820498944027131e-05 1.9930268638375372e-06 0.19873443817163594 0.06624405221284366 5.436913693004511e-11 10.264647561048205 0.515639668550189 SDVEAIFSK(ub)YGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDVEAIFSKYGK 12 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 87741000.0 24989000.0 22977000.0 39775000.0 True False 32348753.106831692 21698309.751593698 32536358.125964325 1.0 0.6707618584226438 1.005799451327013 24.947206768353297 -10.951621779266933 10.75185706455508 1.048820953690599 0.8382806548751068 0.23702156751596204 0.1367785245443364 0.08493411463408207 0.000382162494655784 0.07027102135542422 0.044145078973253093 1.1178363313618715e-11 10.951621779266933 -0.2105402988154922 SDVEDHSVHLLFSANR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDVEDHSVHLLFSANR 16 0 P23919;H7BZ20;H7C312;G5E9E9;H7C3A4;P23919-2 P23919;P23919-2 DTYMK Thymidylate kinase 0 24834300.0 4638600.0 13550000.0 6645700.0 False True 7037095.327084262 11131896.633366799 5332174.482086214 1.0 1.5818879972426307 0.7577237815102241 22.746548625750453 -6.717019969805173 1.7699455031854472 1.3551457654771404 0.7592152303467234 0.4983622773928642 0.24495625494024317 0.36119038904381273 2.209651437381204 0.10995692359635963 0.2770148863959934 1.9185805181354923e-07 6.717019969805173 -0.5959305351304169 SDVETIFSK(ub)YGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDVETIFSKYGR 12 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2 Q5QPL9 RALY RNA-binding protein Raly 1 8650300.0 2548400.0 4298600.0 1803300.0 True False 2119107.5132620702 4275442.5885947 2180361.692482862 1.0 2.0175675664578496 1.028905649589482 21.015025354257105 -6.639454566337848 2.0461796385837903 1.6657060678407776 1.0329980118943782 0.15255640010086313 0.43544664421668083 0.5347912292070922 4.278627019773109 0.17333045906079325 0.4822543004764796 2.2937465779037142e-07 6.639454566337848 -0.6327080559463993 SDVLELTDDNFESR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDVLELTDDNFESR 14 0 H7BZJ3 H7BZJ3 PDIA3 0 39458600.0 4719600.0 16724000.0 18015000.0 False True 6187441.304671411 14228844.389641428 16150980.612082308 1.0 2.2996330290679117 2.6102842543150424 22.560911503769663 -10.286667293112233 0.3189088268838157 4.454927668985347e-12 2.6953008739975246 0.998993781934803 0.022125378791973693 1.7481489260181988 0.14920471751734493 1.5915048908121914 0.10290699361033474 5.1681214015938044e-11 10.286667293112233 2.6953008739930695 SDVLELTDDNFESR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDVLELTDDNFESR 14 0 H7BZJ3 H7BZJ3 PDIA3 0 41208800.0 11463000.0 5528800.0 24217000.0 False True 11099113.33952896 7736478.672311109 17873841.205572736 1.0 0.6970357393106359 1.6103846008956326 23.403941094682658 -6.817298654433098 1.3835414395907526 0.8362457941790217 1.6291890890442466 0.8780550457302485 0.13264538638278073 0.1970137256956782 0.7417436128425182 0.07535433696512434 0.17381547857175883 1.5230050576770777e-07 6.817298654433098 0.792943294865225 SDVLELTDDNFESR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDVLELTDDNFESR 14 0 H7BZJ3 H7BZJ3 PDIA3 0 40815600.0 4719600.0 20219000.0 15877000.0 False True 6464563.662394301 19325657.7247082 12127179.597079111 1.0 2.989475969914185 1.8759471219419517 22.624121565292555 -10.48376434954232 6.02157083348324 0.9988841415166341 2.4327115459280657 0.6882072904059515 0.4545962485668598 0.0068136541868258115 0.0005841399099420643 0.4403975658214429 0.14672030832898442 3.282733676431495e-11 10.48376434954232 1.4338274044114316 SDVQIHVPTFTFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDVQIHVPTFTFR 13 0 F8WEG8;G5E9Q4;C9JMM3;O75569-3;O75569-2;O75569 F8WEG8 PRKRA Interferon-inducible double-stranded RNA-dependent protein kinase activator A 0 16025600.0 5396400.0 4742200.0 5887000.0 False True 7074732.658811939 4034682.244950822 5277869.712091506 1.0 0.5702946584031582 0.7460168414304181 22.75424420149577 -10.161268323696413 5.310168320902572 1.0000120232506806 0.6581557499166552 0.8345997576120506 0.07173828081792258 1.0211743349498103e-05 1.6129493526970886e-06 0.06946273345535545 0.02315343057437988 6.898134790747085e-11 10.161268323696413 -0.34185627333402546 SDVQIHVPTFTFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDVQIHVPTFTFR 13 0 F8WEG8;G5E9Q4;C9JMM3;O75569-3;O75569-2;O75569 F8WEG8 PRKRA Interferon-inducible double-stranded RNA-dependent protein kinase activator A 0 17848100.0 5469700.0 4680600.0 7697800.0 False True 5296067.3674624115 6549587.989006548 5681515.250950063 1.0 1.2366889494732307 1.072780018973274 22.336490043071606 -10.258465975802977 3.9803416441067143 0.9998280732322952 1.1547344841256872 0.5430137660955703 0.06691554073598534 6103042.794051441 16008148.170245772 4947.888838313845 0.022906967905481638 5.514854060463025e-11 10.258465975802977 0.15490641089339208 SDVQIHVPTFTFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDVQIHVPTFTFR 13 0 F8WEG8;G5E9Q4;C9JMM3;O75569-3;O75569-2;O75569 F8WEG8 PRKRA Interferon-inducible double-stranded RNA-dependent protein kinase activator A 0 14881200.0 3791500.0 6138700.0 4951000.0 False True 5751982.695778895 5043201.02311798 3972432.6798996166 1.0 0.8767761117951457 0.6906197201905344 22.455627904915097 -6.965138658078997 0.35566496418819343 1.0168568005840992 0.5442023912156123 0.9999159728273909 0.00116572495179409 0.07791394571221782 0.014694234371169707 0.002520828958251201 0.015942343537076194 1.083580901718593e-07 6.965138658078997 -0.4726544093684869 SDVQIHVPTFTFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDVQIHVPTFTFR 13 0 F8WEG8;G5E9Q4;C9JMM3;O75569-3;O75569-2;O75569 F8WEG8 PRKRA Interferon-inducible double-stranded RNA-dependent protein kinase activator A 0 22079900.0 5396400.0 6544500.0 10139000.0 False True 7391594.912226593 6255342.350232583 7744377.019259628 1.0 0.8462777552765356 1.0477274676470014 22.81745426301866 -6.702757749172191 1.8211537887730376 0.9048037473869626 1.0471580930780537 0.430647038983909 0.06485584096607976 0.3897996041429902 2.5153025242743454 0.028391351600941965 0.0727643296144215 1.9826326361395477e-07 6.702757749172191 0.14235434569109118 SDVQIHVPTFTFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDVQIHVPTFTFR 13 0 F8WEG8;G5E9Q4;C9JMM3;O75569-3;O75569-2;O75569 F8WEG8 PRKRA Interferon-inducible double-stranded RNA-dependent protein kinase activator A 0 12407200.0 5469700.0 3449100.0 3488400.0 False True 4548297.898795151 3430519.0137072555 4217808.311460771 1.0 0.7542423759481549 0.9273377437696138 22.116895318505883 -9.986526544906805 5.363461311301447 1.0000005837736692 0.8407900600571554 0.5300746719195386 0.07066588800176374 4.932717850964919e-07 9.324222069477122e-08 0.06842220214404546 0.022807317281107714 1.0315100296528714e-10 9.986526544906805 -0.15921052371651379 SDVQIHVPTFTFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDVQIHVPTFTFR 13 0 F8WEG8;G5E9Q4;C9JMM3;O75569-3;O75569-2;O75569 F8WEG8 PRKRA Interferon-inducible double-stranded RNA-dependent protein kinase activator A 0 16904600.0 3791500.0 7520200.0 5592900.0 False True 4908171.491638409 7101694.25921292 4575049.588000146 1.0 1.4469124135763003 0.9321291229929981 22.226754227007547 -6.677145785598249 1.9118600509457373 1.2834864334608334 0.9341225395627064 0.3111613824903292 0.18953124227046023 0.44490891486573864 3.141585043695318 0.07961623484020268 0.21076640517024192 2.103072354057908e-07 6.677145785598249 -0.34936389389812694 SDYDGIGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDYDGIGSR 9 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;F6S8Q4;A0A2R8YDH3;A0A2R8YCU0;A0A2R8Y650;A0A2R8YF89 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 0 3798480.0 1030700.0 641680.0 2126100.0 False True 997980.9926766554 897906.1703169935 1569210.6283671877 1.0 0.8997227170717408 1.5723852857742853 19.928652813013112 -6.868957684327931 1.1395316552311014 0.9436237114578472 1.61101781239672 0.963635127486028 0.05650358826091865 0.137861556178746 0.3352234033659735 0.03850419916741793 0.09100323314681545 1.3522043093918475e-07 6.868957684327931 0.6673941009388729 SDYLNTFEFMDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDYLNTFEFMDK 12 0 O75874 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 4804310.0 844710.0 2056500.0 1903100.0 False True 1107422.9901832754 1749678.216174213 1706185.4678242449 1.0 1.5799547523251671 1.5406809168210205 20.078774947071885 -10.183790510742307 4.913656849990417 0.9999453185354913 1.5603178345743034 0.9963288530508065 0.016033476208782895 9.60588528613421e-06 1.595634890426966e-06 0.015525855617033964 0.005174782194261841 6.549520250230468e-11 10.183790510742307 0.5603725160388121 SDYLNTFEFMDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDYLNTFEFMDK 12 0 O75874 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 3716010.0 844710.0 1551700.0 1319600.0 False True 1157022.1144294196 1483140.763214287 1007937.6580150909 1.0 1.2818603419224113 0.8711481357572417 20.141985008594776 -6.72206345293974 1.7524909449566333 1.1711078666169967 0.8717393567099215 0.5219763949950398 0.11857881488838147 0.3513187711596127 2.109885614220515 0.05370951054686389 0.13447427168361958 1.896428821731563e-07 6.72206345293974 -0.2993685099070752 SDYSEAAK(ub)QYDEALNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SDYSEAAKQYDEALNK 16 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 8343900.0 2641300.0 2669300.0 3033300.0 True False 3462769.878385582 2271050.8448499055 2719443.213468174 1.0 0.6558480420618417 0.7853375502781135 21.723495084395207 -10.090214887718213 5.61491866128486 1.0000021770487375 0.7205927967229017 0.8612633509949523 0.05286387036250862 1.4406920495079514e-06 2.3350913301201303e-07 0.051185620482660704 0.01706174079414155 8.124284293385325e-11 10.090214887718213 -0.27940938032583584 SDYSEAAK(ub)QYDEALNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SDYSEAAKQYDEALNK 16 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 12200600.0 3201800.0 3135000.0 5863800.0 True False 3100160.61157671 4386821.848809031 4327894.869770714 1.0 1.415030509202534 1.39602279108036 21.563911529185905 -10.116970878700055 4.794902366920364 0.9999763422150145 1.4055266501448447 0.9983549933231937 0.007759868440699605 1.9626482217051536e-06 3.614479982668068e-07 0.007513898122459885 0.002504486768302935 7.638870037466766e-11 10.116970878700055 0.40555030792983016 SDYSEAAK(ub)QYDEALNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SDYSEAAKQYDEALNK 16 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 30111300.0 4228600.0 8911700.0 16971000.0 True False 6415095.352069274 7321337.507570099 13616674.411346445 1.0 1.1412671372388106 2.122598911480592 22.613039278588488 -6.932820126967478 0.7232708927366029 0.9865264485232939 2.3393348701392784 0.9970640473256205 0.027051225605041963 0.09119963199621921 0.07069928348927582 0.025072204176004875 0.0874573783297453 1.1672929781483249e-07 6.932820126967478 1.3528084216159846 up SDYSEAAK(ub)QYDEALNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SDYSEAAKQYDEALNK 16 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 9101700.0 2641300.0 2260400.0 4200000.0 True False 3617859.98844861 2160528.0538567854 3208046.501715204 1.0 0.5971839874276756 0.8867248903932461 21.7867051459181 -9.924615849719093 6.27551424484085 1.0000000460370875 0.7419544389104363 0.5143363804799566 0.1182045786551454 7.621143228315643e-08 1.3044640744418242e-08 0.11445111160957248 0.03815036371472397 1.189553968748826e-10 9.924615849719093 -0.25804560712665114 SDYSEAAK(ub)QYDEALNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SDYSEAAKQYDEALNK 16 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 9827700.0 3201800.0 3319400.0 3306500.0 True False 2662438.5637900247 3301517.7333506895 3997873.8624713416 1.0 1.2400352737720735 1.501583517022193 21.34431680462018 -6.97002591327392 0.25757002431392273 0.9243569828736704 1.8249970182727566 0.9999825822946204 0.0008548428972277115 0.07629433674956597 0.009000226739540424 0.005546781430525754 0.024768512433230094 1.0714553722472978e-07 6.97002591327392 0.9006400353990862 SDYSEAAK(ub)QYDEALNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SDYSEAAKQYDEALNK 16 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 30112600.0 4228600.0 5622000.0 20262000.0 True False 5474006.058167529 5309130.757864822 16574523.905676661 1.0 0.9698803219158473 3.0278599858227278 22.384165600680937 -6.903582194824127 0.938371137743276 0.9226418224820391 3.260285961554917 0.988265031302886 0.10433293652033057 0.10881546382954603 0.16293337108073908 0.0827960548074919 0.2195560499636165 1.2485841144774808e-07 6.903582194824127 2.337644139072878 up SEAEEAITSFNGHKPPGSSEPITVK(ub)FAANPNQNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEAEEAITSFNGHKPPGSSEPITVKFAANPNQNK 34 2 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 1 74889300.0 15389000.0 14110300.0 45390000.0 True False 19921363.86254081 13325049.401049444 37129485.740729615 1.0 0.6688823864165865 1.8638023981152285 24.247813085230383 -6.832777771053589 1.315356370283173 0.8233819955166284 1.8978427313669914 0.9113354109608797 0.14999143495349523 0.17740655577859946 0.5992948835775531 0.0895035231351001 0.20598390564579472 1.4696781211192254e-07 6.832777771053589 1.074460735850363 SEALPTDLPAPSAPDLTEPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEALPTDLPAPSAPDLTEPK 20 0 K7ELL7;P14314-2;P14314 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 24080900.0 9005300.0 2711600.0 12364000.0 False True 8719431.680752005 3794356.0208071936 9125497.487950666 1.0 0.4351609324703087 1.0465702149023133 23.055802674729996 -12.007324610891338 18.502106068168462 0.9112929115388181 0.7667790163176811 0.0 0.2843974305848399 0.0 0.0 0.0 0.08275395907342839 9.832758871696337e-13 12.007324610891338 -0.144513895221137 SEASLHPVLMSEAPWNTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEASLHPVLMSEAPWNTR 18 0 O96019;O96019-2;H7C5S0 O96019 ACTL6A Actin-like protein 6A 0 10997900.0 3414900.0 2503500.0 5079500.0 False True 3306495.8687217515 3503160.605580034 3749026.568266372 1.0 1.0594782950490456 1.1338367616698997 21.656871668334468 -6.9681085337852195 0.2999633653668596 0.9870981303542704 1.2085467003296506 0.9999636195931884 0.0003301870950880765 0.07692153705481787 0.011216306055799066 0.0012338531844021268 0.006669127122598043 1.076196229676253e-07 6.9681085337852195 0.2214485699753802 SEATFQFTVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEATFQFTVER 11 0 Q93009;A0A669KBL1;Q93009-3;F5H2X1;H3BQD1;H3BUV0;H3BTM1;H3BRA2;H3BMF6 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 21137100.0 6087800.0 8483100.0 6566200.0 False True 9235637.677795801 6969224.526237186 5268387.6919323085 1.0 0.754601335540967 0.5704411406911833 23.13878014534867 -7.052225161142177 0.12042859036910611 1.334630928363211 1.970070938587038e-08 0.9999994457696793 0.00013086879273310956 0.07259569641793798 0.003696384398120973 0.013589542408125663 0.026710222222894403 8.866961828276607e-08 7.052225161142177 -1.3346309086625017 SEAVVEYVFSGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEAVVEYVFSGSR 13 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 28402000.0 8422200.0 9235800.0 10744000.0 False True 11041585.760700833 7857854.640866426 9632313.94372534 1.0 0.7116599744969667 0.8723669002335365 23.396444046908222 -10.126531503769225 4.995255632378614 1.0000090123193515 0.7920134377496841 0.6907150352761579 0.06560832769968251 6.585312614679835e-06 1.1514959067779984e-06 0.06352774223657437 0.021174996712492754 7.472544263073495e-11 10.126531503769225 -0.20799557456966733 SEAVVEYVFSGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEAVVEYVFSGSR 13 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 26264900.0 8251400.0 3747500.0 14266000.0 False True 7989463.823588008 5243896.292954327 10529306.629173746 1.0 0.6563514659735117 1.3178990307318412 22.92966725583083 -6.765525321313159 1.591475737160007 0.8017663632881668 1.3210152203728414 0.7131722734619362 0.14467904965249548 0.27373829602161764 1.36754408675344 0.07168532958116905 0.17135824627560703 1.7158316665345048e-07 6.765525321313159 0.5192488570846746 SEAVVEYVFSGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEAVVEYVFSGSR 13 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 51813000.0 4921100.0 38726000.0 8165900.0 False True 7465668.480600685 31815042.73238095 6551906.285758885 1.0 4.26151292614337 0.8776047721357861 22.831840015279322 -6.654530886577442 1.992245629232774 3.108732025301573 0.8917585943482906 0.21271988918046625 1.390502465186824 0.4974868422885122 3.7897225986325926 0.5650363671077175 1.540733014269331 2.2154865275837886e-07 6.654530886577442 -2.2169734309532823 SEAVVEYVFSGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEAVVEYVFSGSR 13 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 28028300.0 8422200.0 10101000.0 9505100.0 False True 11536114.941397019 9654704.420459826 7260191.143679334 1.0 0.8369112538757909 0.6293445566866143 23.459654108431113 -6.967843639673714 0.3053320253389418 1.0337923140995156 0.4259098138841667 0.9999603393599067 0.0009552267260825896 0.07700879471469835 0.011521510638789274 0.0033557769484346403 0.018513289338016096 1.0768528463592959e-07 6.967843639673714 -0.6078825002153488 SEAVVEYVFSGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEAVVEYVFSGSR 13 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 17204000.0 8251400.0 3868800.0 5083800.0 False True 6861404.698999634 3847958.0065033273 6146799.075164628 1.0 0.560811987531408 0.8958514101435829 22.710072531265105 -10.36918152114422 6.040459570697249 1.0000420344577168 0.7283316988374956 0.46713479037351346 0.13677927151942068 7.743979084433207e-05 8.087146176537423e-06 0.13245640524523455 0.044145320058424836 4.273842159399821e-11 10.36918152114422 -0.2717103356202212 SEDDESGAGELTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEDDESGAGELTR 13 0 P33993;P33993-3;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 0 5782300.0 1302100.0 0.0 4480200.0 False True 1260765.5482335053 0.0 3306701.216880996 1.0 0.0 2.622772506366556 20.26586858658535 -6.803371621588124 1.44209469718235 0.4505922528134054 2.662069375118137 0.841840779047943 0.42980891442774805 0.21598039810655573 0.8863666900900563 0.23443264841739575 0.5441264073946793 1.5726365986264806e-07 6.803371621588124 2.211477122304731 SEDGVEGDLGETQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEDGVEGDLGETQSR 15 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5881290.0 856190.0 5025100.0 0.0 False True 1122473.381355755 4275374.667686381 0.0 1.0 3.8088873542127684 0.0 20.098249802227 -6.709227097921229 1.7983216570910499 2.7284352399115517 0.009478300409000544 0.4609186548843255 1.1838327661317052 0.37682953461386653 2.375152892641119 0.5239943036679949 1.3322607118878842 1.953317774806954e-07 6.709227097921229 -2.7189569395025512 SEDGVEGDLGETQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEDGVEGDLGETQSR 15 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 11822790.0 2793400.0 909490.0 8119900.0 False True 2704725.0460298522 1272654.0999276948 5993054.598221494 1.0 0.4705299349358147 2.2157722120473715 21.367050510921224 -6.825313871732678 1.3486213526033508 0.7160377471858619 2.258425233874098 0.8961841304123305 0.2354106925620851 0.18667190026374114 0.6656101332782834 0.13711231939883298 0.31568166407845527 1.4951546927502475e-07 6.825313871732678 1.5423874866882363 up SEDGVEGDLGETQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEDGVEGDLGETQSR 15 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9959990.0 856190.0 3637200.0 5466600.0 False True 1172746.580664756 3476496.4773880295 4175501.668161037 1.0 2.964405554196903 3.5604466787651674 20.16145986374989 -9.681380910101671 0.32772533846069113 4.0389678347315804e-24 3.732400073660917 0.9986546408713172 0.040124214373681424 1.0415415832791752 0.1380263056143946 1.281307465271974 0.18908565057793172 2.082663423694664e-10 9.681380910101671 3.732400073660917 SEDLSDIASLK(ub)ALYQTGVDNCGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEDLSDIASLKALYQTGVDNCGR 23 1 Q9NXN4-2;Q9NXN4 Q9NXN4-2 GDAP2 Ganglioside-induced differentiation-associated protein 2 1 35199000.0 11212000.0 10890000.0 13097000.0 True False 17009423.70699539 8946594.416041642 10508372.209380986 1.0 0.5259786909983444 0.6177970747509367 24.01983092636838 -10.123625940531225 5.47738347758425 1.0000067814180436 0.5718878828745558 0.9666515634002556 0.03748469820055867 3.104235645485874e-06 4.966211312511788e-07 0.03629497787171801 0.012098134322305443 7.522705485140279e-11 10.123625940531225 -0.4281188985434877 SEDMDNVQSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEDMDNVQSKR 11 1 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 3814500.0 871630.0 940270.0 2002600.0 True False 843960.5827561393 1315724.7144432734 1478058.9832877712 1.0 1.5589883477098945 1.7513365120215019 19.686816093760015 -11.231317301989915 0.1988581722269651 7.945865085677552e-14 1.9012990119826012 0.9993875976545629 0.007886123586537267 3.5266607714746585 0.11429776410700045 1.6891873003094986 0.1214607542168437 5.870602808573534e-12 11.231317301989915 1.9012990119825217 SEDMDNVQSK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEDMDNVQSKR 11 1 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 3239730.0 871630.0 1065600.0 1302500.0 True False 724798.964756168 1059859.4012949618 1574846.7279204382 1.0 1.4622805120196503 2.1728048803853324 19.46722136919429 -6.964849436826845 0.3606327189094985 0.9392149456641812 2.720243012086248 0.9999100010117735 0.0045760163498852644 0.0780121649594117 0.015040723798691716 0.009520616958332707 0.0606648139895651 1.084302759847204e-07 6.964849436826845 1.7810280664220668 SEDMLK(ub)ILKPSIPLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEDMLKILKPSIPLER 16 2 Q7Z6M2 Q7Z6M2 FBXO33 F-box only protein 33 1 7710000.0 1915600.0 3235400.0 2559000.0 True False 2511370.150696791 2752690.9314904246 2294219.227661315 1.0 1.0960912833684346 0.9135328884213956 21.2600432523416 -6.7636872194583715 1.5985964935815977 1.0555584180344215 0.9127416102494921 0.7058439360314678 0.04044046651754936 0.2767619623729205 1.3947261779693598 0.019952411116707043 0.04777575012857583 1.723109117966662e-07 6.7636872194583715 -0.14281680778492944 SEDMLK(ub)ILKPSIPLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEDMLKILKPSIPLER 16 2 Q7Z6M2 Q7Z6M2 FBXO33 F-box only protein 33 1 10326400.0 3073900.0 2115500.0 5137000.0 True False 2976320.7270677895 2960230.1821867637 3791465.593303348 1.0 0.9945938135179142 1.2738766890349962 21.505098568356978 -6.902489282547653 0.9454215497541896 0.9891681278918533 1.304717689793797 0.9877638762766716 0.01442441749296321 0.1095953602270926 0.1672765223807334 0.011387399263466687 0.030014946551843905 1.251730162654778e-07 6.902489282547653 0.31554956190194383 SEDMLK(ub)ILKPSIPLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEDMLKILKPSIPLER 16 2 Q7Z6M2 Q7Z6M2 FBXO33 F-box only protein 33 1 21089300.0 4470400.0 9494900.0 7124000.0 True False 6781923.630017135 7800460.911007703 5715938.277439875 1.0 1.1501841271822157 0.8428196171571211 22.693263107857984 -6.773843633205775 1.5597702966116564 1.0857180233683423 0.8408351026853426 0.7450343695513739 0.06336601752105808 0.26025908065424863 1.2500987777027732 0.032012155247984515 0.075935831344093 1.6832800133267902e-07 6.773843633205775 -0.24488292068299977 SEDMLK(ub)ILKPSIPLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEDMLKILKPSIPLER 16 2 Q7Z6M2 Q7Z6M2 FBXO33 F-box only protein 33 1 9221500.0 1915600.0 3431800.0 3874100.0 True False 2623849.0871435166 3280171.7285550013 2959117.369594017 1.0 1.250137343884361 1.1277772735075606 21.32325331386449 -10.213399239269384 4.306616535593877 0.9999291186115252 1.1889573086044989 0.7607486025938353 0.04995328971695083 5308065.722021156 12588400.569521613 2309.4080587723483 0.01710034032608227 6.117877274563175e-11 10.213399239269384 0.18902818999297366 SEDMLK(ub)ILKPSIPLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEDMLKILKPSIPLER 16 2 Q7Z6M2 Q7Z6M2 FBXO33 F-box only protein 33 1 10204800.0 3073900.0 4317100.0 2813800.0 True False 2556084.046859316 4293842.925422741 3402152.5704587544 1.0 1.6798520106170316 1.331001840349894 21.285503843791254 -10.03949131590414 4.346367638845229 0.9999674033508472 1.5054269254579264 0.7367615390756388 0.1424174859232734 18474603.12831834 10668428.083326496 5452.032411643216 0.04875329371168385 9.130796929331776e-11 10.03949131590414 0.5054595221070792 SEDMLK(ub)ILKPSIPLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEDMLKILKPSIPLER 16 2 Q7Z6M2 Q7Z6M2 FBXO33 F-box only protein 33 1 17153400.0 4470400.0 6953800.0 5729200.0 True False 5787020.924758101 6566814.917118525 4686544.386556248 1.0 1.134748777047669 0.8098371247469003 22.464389429950433 -6.7940449189329435 1.479911478160802 1.0749151584753518 0.8059743414108976 0.8142523901468672 0.05744425163577506 0.22935861250546452 0.9921841862886156 0.030544825957605107 0.07131494855167433 1.6067750562117665e-07 6.7940449189329435 -0.26894081706445416 SEDPDTSMDSYAK(ub)SLLHGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEDPDTSMDSYAKSLLHGR 19 1 P50416;P50416-2 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 1 7840100.0 2296900.0 2749500.0 2793700.0 True False 3011258.1432112386 2339285.3174670553 2504634.723062689 1.0 0.776846489478453 0.8317568949408366 21.52193495920912 -10.138466059131694 5.101073287529324 1.0000078856787022 0.8043016922093614 0.9442453240958765 0.02241707915968206 2.0104735051929964e-06 3.3956090685392675e-07 0.021706117966099933 0.007235081187863602 7.269992132456394e-11 10.138466059131694 -0.19570619346934082 SEDPDTSMDSYAK(ub)SLLHGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEDPDTSMDSYAKSLLHGR 19 1 P50416;P50416-2 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 1 11207000.0 2496000.0 3559100.0 5151900.0 True False 2416765.846241322 4980267.1904613115 3802462.836312933 1.0 2.0607156453352227 1.573368327025441 21.204646270466238 -10.181173706048197 5.413598126826698 0.9999698391250542 1.8170419861804787 0.7893661466867997 0.1989587095626355 7.242934632846629e-05 1.0955293066259726e-05 0.19264802788442972 0.0642136473931753 6.589102962319225e-11 10.181173706048197 0.8170721470554245 SEDPDTSMDSYAK(ub)SLLHGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEDPDTSMDSYAKSLLHGR 19 1 P50416;P50416-2 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 1 20042200.0 2632000.0 6330200.0 11080000.0 True False 3992936.4249743037 5200526.351921651 8890033.143463492 1.0 1.3024315437116227 2.2264399422589616 21.929018671071127 -6.951039794825509 0.5473122292131002 0.9870128833575768 2.5850673126549712 0.999280357606264 0.013994839942115915 0.0830709431271193 0.03425545227063545 0.015242667862565177 0.07661620942175283 1.1193353129851889e-07 6.951039794825509 1.5980544292973944 up SEDPDTSMDSYAK(ub)SLLHGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEDPDTSMDSYAKSLLHGR 19 1 P50416;P50416-2 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 1 9498200.0 2296900.0 2422700.0 4778600.0 True False 3146126.001388564 2315657.1032024557 3649993.0983562535 1.0 0.7360344443230897 1.1601547734405122 21.58514502073201 -6.738391852274615 1.692467075583804 0.8426474771818551 1.1603217112833475 0.5977026774427221 0.11091257983112146 0.320758309669772 1.8034088896373104 0.051854969397153956 0.12747850898097615 1.8264515142011397e-07 6.738391852274615 0.3176742341014924 SEDPDTSMDSYAK(ub)SLLHGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEDPDTSMDSYAKSLLHGR 19 1 P50416;P50416-2 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 1 11549700.0 2496000.0 2640400.0 6413300.0 True False 2075534.5915484722 2626175.6411216375 7754291.378251172 1.0 1.2653008298755235 3.7360453590253146 20.985051545900514 -6.9273840893817615 0.7679633939989766 0.958558072342708 4.211059112046697 0.995998650587143 0.0779330645606315 0.09401895334175049 0.08450321750178842 0.06992580235061406 0.2268602167320492 1.1819957380937315e-07 6.9273840893817615 3.252501039703989 up SEDPDTSMDSYAK(ub)SLLHGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEDPDTSMDSYAKSLLHGR 19 1 P50416;P50416-2 P50416 CPT1A Carnitine O-palmitoyltransferase 1, liver isoform 1 16453200.0 2632000.0 4319000.0 9502200.0 True False 3407175.88447641 4078643.8532938743 7772897.100805486 1.0 1.1970746423384746 2.281331332561943 21.700144993163576 -6.937697353032166 0.6806561226821173 0.9872088947855525 2.554916284572797 0.9978463750090519 0.026143439167664248 0.08883312871682653 0.05951400120102301 0.025024744914911967 0.09430568938740178 1.1542573453901706e-07 6.937697353032166 1.5677073897872442 up SEDQEEGGRPK(ub)KEEAAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEDQEEGGRPKKEEAAAR 18 3 H3BQQ2;H3BPG6;Q86UK7-2;Q86UK7-3;Q86UK7 H3BQQ2 ZNF598 Zinc finger protein 598 1 1287280.0 339900.0 581470.0 365910.0 True False 329110.06055185373 813654.003325992 270067.19393529836 1.0 2.4722854171083437 0.8205984146532866 18.328210603258302 -6.671608212136157 1.9313433153112283 1.9384652106749813 0.8271897849187629 0.2862021021108774 0.6251675186171616 0.45751670629037644 3.2915449382982214 0.2604293487353085 0.6944293163912352 2.1300597594273516e-07 6.671608212136157 -1.1112754257562183 SEDQEEGGRPK(ub)KEEAAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEDQEEGGRPKKEEAAAR 18 3 H3BQQ2;H3BPG6;Q86UK7-2;Q86UK7-3;Q86UK7 H3BQQ2 ZNF598 Zinc finger protein 598 1 1775680.0 454190.0 644880.0 676610.0 True False 587957.908423381 608991.86110492 553473.9226048699 1.0 1.035774589269395 0.9413495671637779 19.165353351467083 -6.804083405870931 1.4395220900190329 1.0196374275669546 0.9399160912806047 0.8437346817060344 0.015386859981359583 0.21498815505408755 0.8791106888109361 0.008407878353979508 0.01950405301107907 1.5700612465045192e-07 6.804083405870931 -0.07972133628634992 SEDTISK(ub)MNDFMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEDTISKMNDFMR 13 1 Q16666;Q16666-2;Q16666-6 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 5752200.0 2103100.0 2398200.0 1250900.0 True False 2757184.466449372 2040397.9081103841 1121468.867480084 1.0 0.7400295239360439 0.4067442280799882 21.39476436185508 -6.967735222428604 0.30750899929138065 1.0528793917022585 0.08333823742222551 0.9999589388077579 0.0015559002989649383 0.07704462150484413 0.011646959376225365 0.005333680808216751 0.029661688676739576 1.0771217053886604e-07 6.967735222428604 -0.969541154280033 down SEDTISK(ub)MNDFMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEDTISKMNDFMR 13 1 Q16666;Q16666-2;Q16666-6 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 13890800.0 2153300.0 2866200.0 8871300.0 True False 2084944.6701568302 4010688.6070355405 6547640.396704688 1.0 1.92364270593994 3.1404384444466684 20.991577667550697 -6.967324681599153 0.31561975807143383 0.8245583376376605 4.278518513231428 0.9999533572642819 0.005986492395832756 0.07718072809373047 0.012123176037924732 0.018783042258129008 0.1074561578955 1.0781403955419785e-07 6.967324681599153 3.4539601755937674 SEDTISK(ub)MNDFMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEDTISKMNDFMR 13 1 Q16666;Q16666-2;Q16666-6 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 5030800.0 2103100.0 1671400.0 1256300.0 True False 2880672.9041404915 1597552.0214193205 959587.8143106694 1.0 0.5545759878266996 0.33311238250320624 21.457974423377973 -10.57938583434289 0.1430425253163781 1.8700121946054415 3.3146539796556508e-21 0.9997250066455033 0.004598873507618834 2.4510857931082475 0.07642971435060478 0.9520992187653127 0.21436503130374202 2.6339902658684317e-11 10.57938583434289 -1.8700121946054415 SEDTISK(ub)MNDFMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEDTISKMNDFMR 13 1 Q16666;Q16666-2;Q16666-6 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 10672000.0 2153300.0 3327400.0 5191300.0 True False 1790564.3573643165 3309474.6357628116 6276776.828140785 1.0 1.8482857776943065 3.5054740156785567 20.771982942984973 -6.960501592737367 0.42830584683618367 0.9329788394230808 4.4841540582879 0.9997883529016676 0.015136903979252945 0.07952242151220008 0.020472829139753672 0.021575220679932335 0.13765288773582154 1.0952125387623209e-07 6.960501592737367 3.5511752188648193 SEEAHAEDSVMDHHFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEEAHAEDSVMDHHFR 16 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 11052620.0 2551400.0 824620.0 7676600.0 False True 2470407.2035657535 1153895.0663364918 5665868.166936433 1.0 0.46708699062687914 2.2934956466927368 21.236317433864954 -6.828625200357841 1.3341734586667977 0.7149700715194451 2.3412326588437535 0.9030712811270618 0.23875454919991135 0.18251493289550638 0.635884882692008 0.14053140998740796 0.3234030117497001 1.4837980624516457e-07 6.828625200357841 1.6262625873243084 up SEEEFIHINNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEEEFIHINNK 11 0 Q15046;Q15046-2;H3BVA8;J3KRL2 Q15046 KARS Lysine--tRNA ligase 0 9269400.0 0.0 1033200.0 8236200.0 False True 0.0 1445762.1480668196 6078892.139296283 0.0 SEEEKTEFFK(ub)FLLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEEEKTEFFKFLLDR 15 2 X6RHX1;Q8IZE3-2;Q8IZE3 X6RHX1 SCYL3 Protein-associating with the carboxyl-terminal domain of ezrin 1 4002510.0 881780.0 2334000.0 786730.0 True False 1156022.119169666 1985776.2978607437 705326.726447044 1.0 1.7177666974807229 0.6101325526138357 20.140737571757136 -6.731799432661135 1.7168998325590734 1.4310836106012563 0.6105985597855839 0.567508769453701 0.30169065880201623 0.3328637587512199 1.9231060125580028 0.1392107671596191 0.34471014112279735 1.8543878253173557e-07 6.731799432661135 -0.8204850508156725 SEEETSPLVTHQNPAGPVASAPELESK(ub)ESVL ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEEETSPLVTHQNPAGPVASAPELESKESVL 31 1 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 12307400.0 5233800.0 4536900.0 2536700.0 True False 7168877.298126816 4336444.756477995 1937583.704976417 1.0 0.6048987276726137 0.2702771472295524 22.77331576869092 -7.722465253205211 0.2788766167163975 1.1210753426330924 7.857188127475788e-17 0.9996202341036649 0.0058121488263162165 0.12503810993184614 0.039138398237154974 0.03864469575277518 0.07977306116264465 1.894675096418947e-08 7.722465253205211 -1.1210753426330924 down SEEK(ub)ISDSEGFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEEKISDSEGFK 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 4609000.0 1668800.0 2143600.0 796600.0 True False 2187812.9606821896 1823783.2356873571 714175.4735267694 1.0 0.8336102164412981 0.3264335143640798 21.061057974625363 -6.951092187630506 0.5467202077837272 1.0071543602623885 0.1291965253641123 0.9992842395469713 0.007664234129833416 0.0830500901099835 0.03416988896795347 0.008354081193081581 0.04204923726448121 1.1192002857584476e-07 6.951092187630506 -0.8779578348982762 down SEEK(ub)ISDSEGFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEEKISDSEGFK 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 9443600.0 3351200.0 2471300.0 3621100.0 True False 3244817.990354135 3458102.977659247 2672625.279328547 1.0 1.0657309556157368 0.8236595356884286 21.62970612558315 -6.8343908310162265 1.308322730261212 1.0350290155292778 0.8165485237064453 0.9143459408846875 0.02991241626555438 0.1754573436445918 0.5858215778513007 0.017943175255641482 0.04129294812145764 1.4642295559583012e-07 6.8343908310162265 -0.21848049182283258 SEEK(ub)ISDSEGFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEEKISDSEGFK 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 15600400.0 4600700.0 6503700.0 4496000.0 True False 6979598.256223114 5343063.9213599665 3607363.629333197 1.0 0.765525998089648 0.5168440212324281 22.734712567014842 -6.970379652161703 0.24895158524417021 1.079944864531279 0.19515128779684368 0.999985193353243 0.000759084481407909 0.07617969606414567 0.008588239206663484 0.00558617004043337 0.023874846536693087 1.0705830122871613e-07 6.970379652161703 -0.8847935767344354 SEEK(ub)ISDSEGFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEEKISDSEGFK 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 5219000.0 1668800.0 2271600.0 1278600.0 True False 2285800.4576242943 2171233.20082334 976621.0135935848 1.0 0.9498787147325941 0.42725558582161555 21.124268036148255 -6.925522259024323 0.7826726083882848 1.0094031083356854 0.3312524375480122 0.9955826433272728 0.017213314933343375 0.09503041719853597 0.08956515876552829 0.015282857659494676 0.04850461846943993 1.1870738580347021e-07 6.925522259024323 -0.6781506707876732 down SEEK(ub)ISDSEGFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEEKISDSEGFK 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 8732200.0 3351200.0 4059800.0 1321200.0 True False 2786671.283332229 4037929.0515927942 1597456.8114614056 1.0 1.4490152016653874 0.5732491022590969 21.410111401017428 -6.767366081972626 1.5848185532536248 1.2584117728995172 0.5688380048721072 0.720282540430007 0.18911199173090293 0.27070911591865926 1.3414922987165832 0.09408511197227051 0.2244814532590921 1.7085744908594864e-07 6.767366081972626 -0.68957376802741 SEEK(ub)ISDSEGFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEEKISDSEGFK 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 17596300.0 4600700.0 8770300.0 4225300.0 True False 5955696.843355086 8282225.095286699 3456338.755239141 1.0 1.3906391331062085 0.5803416201574232 22.50583888910729 -6.775611053636122 1.5529310311295674 1.222450501922219 0.574779811710492 0.7515682227702567 0.16491694069411694 0.2574533707202841 1.225984383370255 0.08367023578939278 0.1981664512619734 1.6764435967928122e-07 6.775611053636122 -0.647670690211727 SEENEEPMETDQNAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEENEEPMETDQNAK 15 0 P34932;A0A087WYC1 P34932 HSPA4 Heat shock 70 kDa protein 4 0 3031160.0 830470.0 350890.0 1849800.0 False True 804107.1844262944 491002.20686717646 1365281.8871895152 1.0 0.6106178583859954 1.6978854481490568 19.617028294415302 -6.809837081392337 1.4150534586609254 0.7877517232180342 1.7168692236509842 0.8594567693181163 0.16862285076600986 0.20701179340004233 0.8169805219003414 0.09369694710165441 0.21677294331613975 1.5493977416125973e-07 6.809837081392337 0.9291175004329499 SEENTKEEK(ub)PDSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEENTKEEKPDSK 13 2 P50502;Q8NFI4;Q3KNR6;Q8IZP2;F6VDH7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 1 3533540.0 1243000.0 1375200.0 915340.0 True False 1203541.6453838013 1924324.53157326 675584.9943886097 1.0 1.598884873617818 0.561330799793945 20.198854632656477 -6.75019589855066 1.649191420808687 1.3520650434570085 0.5592455096474798 0.6498053774117847 0.2516569634365935 0.2996930578981037 1.6038116478283844 0.12054201465191006 0.2925750344677069 1.777477456947233e-07 6.75019589855066 -0.7928195338095287 SEENTKEEK(ub)PDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEENTKEEKPDSK 13 2 P50502;Q8NFI4;Q3KNR6;Q8IZP2;F6VDH7 P50502 ST13;ST13P5;ST13P4 Hsc70-interacting protein;Putative protein FAM10A5;Putative protein FAM10A4 1 4900200.0 2009500.0 1722400.0 1168300.0 True False 2752466.4546956 1646298.6727848721 892371.6018937783 1.0 0.5981176155576214 0.32420798457740596 21.392293550574596 -8.195876487356605 0.20586146764050894 1.2641324727625753 5.134535392844544e-09 0.9997655851202985 0.004249226218923466 0.08671189963576817 0.04262490860544499 0.10164113194503852 0.11234925611618737 6.369766502722535e-09 8.195876487356605 -1.2641324676280399 down SEEPAGQILSHLSSELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEEPAGQILSHLSSELK 17 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 7906000.0 2427200.0 0.0 5478800.0 False True 2350149.8645821083 0.0 4043737.9195231395 1.0 0.0 1.7206298119384724 21.164321326963663 -6.749161443328354 1.6531227059756262 0.41139560237149586 1.723798710688735 0.6452972195636428 0.420188299239763 0.30150262295728364 1.6208944518733686 0.20082025652173438 0.48793396318228066 1.781716314446793e-07 6.749161443328354 1.312403108317239 SEEQLKEEGIEYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEEQLKEEGIEYK 13 1 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 11037300.0 2696800.0 1103000.0 7237500.0 False True 2611191.560153688 1543433.6520690145 5341781.629654079 1.0 0.5910840382687864 2.0457256798653547 21.31627686870084 -6.831643619806083 1.3205326785135045 0.7817408706869112 2.0862056422856807 0.9091289838855361 0.18464605807790282 0.17878845539000585 0.6091605064969856 0.10976734094670805 0.2526024664908344 1.4735211716201504e-07 6.831643619806083 1.3044647715987696 up SEESSHYSTEK(ub)ESEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEESSHYSTEKESEK 15 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 31169800.0 10686000.0 13227000.0 7256800.0 True False 14009449.483371213 11253583.158442168 6505935.948140925 1.0 0.8032851806061205 0.4643962602430075 23.739896928815735 -6.962854905630258 0.39313615015040054 1.0200996925504167 0.2353437610407717 0.9998618665142994 0.002599905800194926 0.0786966535527802 0.017475377947049064 0.00436868392049841 0.028469519728010248 1.0892939570894593e-07 6.962854905630258 -0.784755931509645 down SEESSHYSTEK(ub)ESEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEESSHYSTEKESEK 15 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 25852300.0 10384000.0 10188000.0 5280300.0 True False 10054365.603914216 14256121.529718133 3897231.0243954915 1.0 1.4179036342350781 0.3876158057031743 23.26131871960313 -6.796565782413838 1.4696941386074074 1.2315867650171144 0.3745362085823983 0.8220066327590146 0.17850433116449457 0.2256840430168864 0.9626868331479292 0.09556270052862428 0.2227441664252347 1.5974755417421626e-07 6.796565782413838 -0.8570505564347162 down SEESSHYSTEK(ub)ESEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEESSHYSTEKESEK 15 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 21864600.0 10951000.0 4058500.0 6855100.0 True False 16613467.625339491 3334228.965794765 5500186.480302936 1.0 0.20069434274571749 0.33106793863514944 23.9858498936678 -10.60080169177576 6.555803562512224 1.001772967153218 0.26588114101209126 0.9768924164086424 0.053224797643487115 0.0013815865125197451 8.412808208818573e-05 0.051622053007388126 0.017178229573207124 2.507253857856881e-11 10.60080169177576 -0.7358918261411268 SEESSHYSTEK(ub)ESEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEESSHYSTEKESEK 15 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 27904900.0 10686000.0 9513000.0 7705900.0 True False 14636902.978291715 9092684.20471581 5885925.127992185 1.0 0.6212164020080856 0.40212913460734956 23.803106990338627 -9.444766526868282 0.1372281302374019 1.6113036506346763 9.35429278620809e-12 0.9998485091863915 0.003039680513225664 0.8898236785461874 0.05299106524233183 0.40678972767212107 0.19749052255391283 3.5911493999132954e-10 9.444766526868282 -1.611303650625322 SEESSHYSTEK(ub)ESEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEESSHYSTEKESEK 15 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 25029000.0 10951000.0 4044000.0 10034000.0 True False 14176285.376482189 3818947.8450382953 8207914.95753427 1.0 0.2693898820190059 0.5789891173572752 23.75697621576025 -10.498008922197325 6.233055332787692 1.0004278991421172 0.4241894996898639 0.8218133866059364 0.12639335855576772 0.0007520983504074243 6.057169028096212e-05 0.1224661424524146 0.040793281063142575 3.1768088052426325e-11 10.498008922197325 -0.5762383994522533 SEFEQNLSEK(ub)LSEQELQFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEFEQNLSEKLSEQELQFR 19 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 50990700.0 8922700.0 15048000.0 27020000.0 True False 13536388.236747038 12362566.82943937 21679485.156713266 1.0 0.913284002587846 1.6015708752989428 23.69033951626884 -6.875305548005661 1.1057059046178408 0.9489750891001097 1.64615168539638 0.9696946361568064 0.05328314936188333 0.1318667281922668 0.2981411943565832 0.037266253070446585 0.08913359549715616 1.3325835627401342e-07 6.875305548005661 0.6971765962962703 SEFEQNLSEK(ub)LSEQELQFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEFEQNLSEKLSEQELQFR 19 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 21103300.0 6567600.0 6492100.0 8043600.0 True False 5461250.394011923 6457125.768719038 9725479.570595656 1.0 1.1823529966322472 1.7808155402029022 22.38079987407955 -6.94941598814605 0.5652171614656941 0.9923762692566932 1.9996511624707116 0.9991546643393251 0.00969679676836899 0.08372107261502747 0.03693920866494815 0.010330111432592012 0.04980681776958829 1.1235282889575771e-07 6.94941598814605 1.0072748932140185 SEFEQNLSEK(ub)LSEQELQFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEFEQNLSEKLSEQELQFR 19 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 39618700.0 8922700.0 11565000.0 19131000.0 True False 11550611.042711874 10921397.583547968 15649354.30063667 1.0 0.9455255261529283 1.3548507730689272 23.46146583836129 -6.873360150695201 1.11610907254706 0.9684638666945632 1.380411134689812 0.9679260262904088 0.03250266026824528 0.13367684073821054 0.3091827519651046 0.022550386779672586 0.05372562357107077 1.3385661840497762e-07 6.873360150695201 0.41194726799524883 SEFVILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEFVILR 7 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 10367400.0 2237500.0 3750400.0 4379500.0 False True 2933384.16798082 3190854.9389446983 3926351.351130414 1.0 1.0877726053662815 1.338505673408982 21.48413459403194 -6.952546081910028 0.5301543936041924 0.9960499398251742 1.4416136659947927 0.9993862464139225 0.003553411367593682 0.0824791640781787 0.031853548941048006 0.003963457200204732 0.02073470450448939 1.1154597864006813e-07 6.952546081910028 0.4455637261696185 SEFVILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEFVILR 7 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 10522400.0 2237500.0 3824400.0 4460500.0 False True 3064764.216163921 3655425.362400409 3407021.766881114 1.0 1.1927264561238586 1.1116750022439204 21.54734465555483 -10.153675321049253 4.480213619112648 0.9999754132618713 1.152200729187997 0.8246122648752464 0.033089117500042564 8.12749479669915e-06 1.5352724049168126e-06 0.03204357363618956 0.010679466749573504 7.019799031138369e-11 10.153675321049253 0.15222531592612565 SEGALELADVSNELPGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEGALELADVSNELPGLK 18 0 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 0 7545300.0 4177600.0 1496700.0 1871000.0 False True 4044984.3747026254 2094340.1151873907 1380928.971203146 1.0 0.5177622262981819 0.341392906197485 21.94770269902947 -13.999999999999998 0.139858606810903 3.303280344186953 0.12275438809382544 0.9996034979446422 0.0055430561031885 11.933877245878161 0.11716022711944729 7.5021227688928 0.19544182583306072 1.0000000000000041e-14 13.999999999999998 -3.1805259560931276 SEGEFK(ub)QTSSFLV ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEGEFKQTSSFLV 13 1 A0A087WY82;Q9Y624;Q9Y624-2 A0A087WY82 F11R Junctional adhesion molecule A 1 6918800.0 1236900.0 3319400.0 2362500.0 True False 1621587.8781566382 2824158.4589198604 2118051.1627002168 1.0 1.7416006230450245 1.3061587294966337 20.628975778714818 -10.172845400970537 4.376219787591729 0.9998759111383225 1.5238796760547841 0.6586948450147495 0.1777684087062703 124634654.56506571 37.641491915326405 157897.07112156384 0.060854854652417155 6.716679089839098e-11 10.172845400970537 0.5240037649164616 SEGEFK(ub)QTSSFLV ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEGEFKQTSSFLV 13 1 A0A087WY82;Q9Y624;Q9Y624-2 A0A087WY82 F11R Junctional adhesion molecule A 1 6281400.0 1236900.0 1731800.0 3312700.0 True False 1694215.3559656565 1655283.3497032316 2530308.4871980855 1.0 0.9770206272034203 1.4934987327841087 20.69218584023771 -6.896487242662264 0.9831979054827424 0.976407604144728 1.54400668294352 0.9847359782479378 0.029433818822501723 0.11403883757997789 0.19235769381581258 0.022592429895207395 0.05781179011097774 1.2691494249788496e-07 6.896487242662264 0.5675990787987919 SEGEFK(ub)QTSSFLV ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEGEFKQTSSFLV 13 1 A0A087WY82;Q9Y624;Q9Y624-2 A0A087WY82 F11R Junctional adhesion molecule A 1 9297400.0 2793800.0 3770800.0 2732800.0 True False 2323168.4863253697 3750485.9519548025 3304215.8449604367 1.0 1.6143839648440939 1.422288510028311 21.147662357810734 -10.085017099697408 4.617445919311502 0.9999706450277508 1.5183362373935194 0.9066114757052642 0.07842264108928763 54507955.044954054 1.7682881017301832 17898.002331389882 0.026846155956570996 8.222102760065722e-11 10.085017099697408 0.5183655923657686 SEGETIMSSSMGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEGETIMSSSMGKR 14 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 9202100.0 3022300.0 4082300.0 2097500.0 True False 3962264.567994831 3473236.752680769 1880470.820640724 1.0 0.8765787072210722 0.4745949666840059 21.917893784279165 -6.949589839402381 0.5633311042506622 1.00516860600499 0.32668353462879296 0.99916868275691 0.00646771319003287 0.08365091514314385 0.03664759512553248 0.0069054541016368085 0.033440445044589824 1.1230786223775539e-07 6.949589839402381 -0.6784850713761971 down SEGETIMSSSMGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEGETIMSSSMGKR 14 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 17585300.0 6221000.0 4708400.0 6655900.0 True False 6023517.760203238 6588488.673981633 4912520.1172800725 1.0 1.0937941807876952 0.8155566751602507 22.52217484251923 -6.8158044309770816 1.390194726964085 1.0507781979185113 0.8100250249450194 0.8743929321885575 0.04096351892555179 0.19899606867604466 0.7568372477079374 0.023162982746512656 0.05344899633107514 1.5282540980094437e-07 6.8158044309770816 -0.24075317297349197 SEGETIMSSSMGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEGETIMSSSMGKR 14 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 25480500.0 6835200.0 6184700.0 12460600.0 True False 10369498.120054834 5080991.963718349 9997756.948324993 1.0 0.48999400982498864 0.964150514574 23.305842734136075 -10.56063278154772 9.339306771524319 1.0000215110909767 0.7270722621994944 0.30640537549684976 0.19357358247610446 8.670811468960265e-05 4.079023900969983e-06 0.18744154753856548 0.06247560509963835 2.750218622359664e-11 10.56063278154772 -0.2729492488914823 SEGETIMSSSMGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEGETIMSSSMGKR 14 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 8942460.0 3022300.0 2374400.0 3545760.0 True False 4139725.9845864675 2269491.1569092013 2708324.515219451 1.0 0.5482225551544347 0.654227967093333 21.981103845802057 -9.841487028582998 6.412249534042345 1.0000000148611827 0.6012252611238282 0.9496691352715289 0.04327652820422605 9.167803821818995e-09 1.6553761669201611e-09 0.04190231950283318 0.013967439418016281 1.4404990341285568e-10 9.841487028582998 -0.3987747537373545 SEGETIMSSSMGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEGETIMSSSMGKR 14 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 20387000.0 6221000.0 8683400.0 5482600.0 True False 5173037.137028471 8636620.80068004 6628986.311321765 1.0 1.6695454859311416 1.281449588651055 22.302580117953507 -10.06778395337333 4.295934677256849 0.9999539420780962 1.4754975371773495 0.6668340583600438 0.1584394868557622 18026824.33405015 8449394.000206655 7533.827273911933 0.05423805088202013 8.554921851015854e-11 10.06778395337333 0.47554359509925337 SEGETIMSSSMGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEGETIMSSSMGKR 14 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 19657400.0 6835200.0 5494000.0 7328200.0 True False 8848301.141935078 5188254.070385865 5994542.793681751 1.0 0.5863559554722864 0.6774795181045087 23.076969056228524 -10.715158039943253 7.564543315672983 1.002577778192807 0.6319177367884051 0.9560543921989928 0.03720103866558151 0.001625329434775165 6.120148382321558e-05 0.03619902353862846 0.01200658360111796 1.9268236136797473e-11 10.715158039943253 -0.3706600414044018 SEGFDTYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEGFDTYR 8 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 17855500.0 2158500.0 9316300.0 6380700.0 False True 2829814.402943731 7926344.354652972 5720486.371996308 1.0 2.8010120898414916 2.0215058507178205 21.432276004454412 -10.37154725337691 5.72908753129929 0.999645883698121 2.4112589702796603 0.8137912656584897 0.31823208952816884 0.0014397146799939734 0.00015793052054003724 0.3081974068341253 0.10270896524761326 4.2506245540147765e-11 10.37154725337691 1.4116130865815393 SEGFDTYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEGFDTYR 8 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 20493300.0 5116300.0 2606000.0 12771000.0 False True 4953885.857021031 3646589.390110473 9425891.978212394 1.0 0.7361068654705163 1.9027269198892198 22.240129197010827 -6.8472648969793175 1.2481766720786802 0.8594388367850682 1.9469709694002042 0.93623741813089 0.12613157357750585 0.16048963024858431 0.48252274165269543 0.07912556389156997 0.18281424176164135 1.4214615052826104e-07 6.8472648969793175 1.0875321326151361 SEGFDTYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEGFDTYR 8 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 79965900.0 6264200.0 68599000.0 5102700.0 False True 9503249.374363218 56356972.483566694 4094149.1084071356 1.0 5.9302845020146595 0.4308157080936826 23.17998945695163 -6.67041103264959 1.9360328386170063 4.145911861715237 0.4530975076673116 0.2807972607177107 2.094088224973446 0.460191257633606 3.32587534717324 0.8706807815281319 2.3248955678312297 2.1359395989144528e-07 6.67041103264959 -3.6928143540479255 SEGFDTYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEGFDTYR 8 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 17614300.0 2158500.0 7860500.0 7595300.0 False True 2956555.781269194 7513197.118802544 5801446.570113687 1.0 2.5411991772322553 1.962231393321872 21.495486065977303 -9.853245253037347 5.787945458415917 0.9999997115445804 2.251715285279771 0.8617293966336828 0.2363626080246581 8.801400801801939e-07 1.7440222169710926e-07 0.2288571656924978 0.07628570371073819 1.4020217368745324e-10 9.853245253037347 1.2517155737351904 SEGFDTYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEGFDTYR 8 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 8876100.0 5116300.0 2603200.0 1156600.0 False True 4254430.140520619 2589176.044905254 1398439.7124858194 1.0 0.608583513981126 0.3287020038633637 22.020534472445103 -8.024282432453894 0.21229807251291055 1.2329457366101833 1.648019966554516e-09 0.9997907721942185 0.003982336606843644 0.09987653606436024 0.0382953204119344 0.07851628088543959 0.10253882888890997 9.456219999617346e-09 8.024282432453894 -1.2329457349621633 down SEGFDTYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEGFDTYR 8 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 15791400.0 6264200.0 5345400.0 4181800.0 False True 8109130.38584236 5047923.791015756 3420755.308891449 1.0 0.6224987823390866 0.42183996879168545 22.95111577904408 -11.019845054822762 0.11346201991059617 2.0046829397311554 3.286400605768456e-17 0.9998411790240305 0.003020605556685983 3.324507144511268 0.0680975199281674 1.1471270835141354 0.27752318512509644 9.553333637679507e-12 11.019845054822762 -2.0046829397311554 SEGGFIWACK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEGGFIWACK 10 0 O75874 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 11800500.0 2863400.0 3675100.0 5262000.0 False True 3753945.129205049 3126789.405427601 4717538.7166681625 1.0 0.8329342326028466 1.2566882451121943 21.839976132012325 -6.799741486050481 1.4568780886750619 0.9077918868578313 1.262506635600459 0.8314316392865287 0.07155501032121009 0.22112611700451965 0.9266035790318197 0.0386385619713968 0.0898768465857521 1.5858368815525544e-07 6.799741486050481 0.35471474874262776 SEGGFIWACK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEGGFIWACK 10 0 O75874 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 8976000.0 2863400.0 2684700.0 3427900.0 False True 3922076.3604754372 2566081.076884317 2618300.61981656 1.0 0.6542659655339436 0.6675802251588919 21.903186193535216 -10.104732526723065 5.58221032623651 1.0000034097828285 0.660923095353631 0.998844958846225 0.005435523730923907 2.3066402511242538e-07 3.699138123909473e-08 0.005262976147825675 0.001754307740612779 7.857193944709177e-11 10.104732526723065 -0.3390803144291975 SEGK(ub)SMFAGVPTMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEGKSMFAGVPTMR 14 1 Q5T8U5;O15260;B7Z1G8;O15260-2 Q5T8U5 SURF4 Surfeit locus protein 4 1 15238400.0 1477600.0 2045800.0 11715000.0 True False 1937147.909098754 1740574.614465941 10502844.178215053 1.0 0.8985243750828157 5.421808076132625 20.885502683088035 -6.901769153136262 0.9500155280915957 0.8209582258805174 5.914037569216073 0.9874261206694218 0.23646507809209685 0.11011473834455245 0.17016628176418733 0.18604171853955667 0.488490045173026 1.2538074523622156e-07 6.901769153136262 5.093079343335556 up SEGK(ub)VGFQAYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEGKVGFQAYK 11 1 O15439;A0A2R8Y6V8;O15439-4;O15439-3 O15439 ABCC4 Multidrug resistance-associated protein 4 1 2774970.0 567770.0 791500.0 1415700.0 True False 744351.9682925013 673411.2852428351 1269216.9443533102 1.0 0.9046947061718666 1.7051300976133879 19.5056254382945 -6.877183116855872 1.095436264087249 0.9428752363987795 1.7588687757347536 0.971339209375739 0.060436921399524335 0.1301522584487578 0.28764005958719496 0.04260339327736044 0.10232387791519074 1.3268348902634002e-07 6.877183116855872 0.8159935393359742 SEGK(ub)VGFQAYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEGKVGFQAYK 11 1 O15439;A0A2R8Y6V8;O15439-4;O15439-3 O15439 ABCC4 Multidrug resistance-associated protein 4 1 5605520.0 686180.0 436840.0 4482500.0 True False 664397.5914959422 611272.4900905049 3308398.777882475 1.0 0.9200401956818927 4.979546615202745 19.341687317840716 -6.902409590639497 0.9459239110300491 0.8421949872436011 5.427117455851045 0.9877269059117721 0.2099472117538756 0.10965315837845957 0.1675922715602958 0.1656804641794328 0.4365172509498845 1.251959872959794e-07 6.902409590639497 4.584922468607444 up SEGLITEK(ub)CSSQQPPGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEGLITEKCSSQQPPGSK 18 1 A0A0A0MRG9;Q96SN8-4;Q96SN8-3;Q96SN8-2;Q96SN8;F8WCI3 A0A0A0MRG9 CDK5RAP2 CDK5 regulatory subunit-associated protein 2 1 8488400.0 1316000.0 3159100.0 4013300.0 True False 1703587.942238205 2983293.3079279196 3282920.579935449 1.0 1.7511824508504175 1.9270625827641676 20.700144993163576 -11.013353206174143 0.27557625982143946 5.340031274774901e-16 1.993536670089648 0.9992257019315995 0.011186973707479578 2.9452479300716177 0.14377475713961002 1.9362380948120348 0.07065255982317792 9.697209847206357e-12 11.013353206174143 1.9935366700896475 SEGVVAVLLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEGVVAVLLTK 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 21633600.0 5372300.0 8935800.0 7325500.0 False True 7043137.325427209 7602613.471475592 6567527.531157853 1.0 1.0794356435488708 0.9324718840065344 22.747786781652643 -6.759934053249415 1.6130053988753346 1.0461452020909228 0.9319421046254415 0.6905863881911083 0.03341019339403621 0.2830292129178564 1.4513713696644674 0.01634379451575678 0.03927476718874929 1.7380647303739707e-07 6.759934053249415 -0.1142030974654813 SEGVVAVLLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEGVVAVLLTK 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 9585900.0 3054500.0 1380200.0 5151200.0 False True 2957536.569448769 1931321.0576479142 3801946.1873124773 1.0 0.6530167970189722 1.2855111333487554 21.495964576684237 -6.757735604153499 1.621091944660156 0.7979011748780634 1.2875648896691232 0.6817538655988262 0.1458966182781699 0.2866676536083626 1.484254978339194 0.07103063547048498 0.17107498924736786 1.74688532245119e-07 6.757735604153499 0.48966371479105975 SEGVVAVLLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEGVVAVLLTK 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 18116600.0 5372300.0 6948800.0 5795500.0 False True 7358584.490948584 6641779.03939128 4426722.26206916 1.0 0.9025892204623037 0.601572526280597 22.810996843175534 -6.950782862339561 0.5501808599162064 1.0041585115538225 0.48585749693352104 0.9992613019025751 0.004609260460458225 0.08317288203659629 0.03467295055793542 0.005001619629108072 0.02497274109247636 1.1199977176548564e-07 6.950782862339561 -0.5183010146203015 SEGVVAVLLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEGVVAVLLTK 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 7426600.0 3054500.0 2015800.0 2356300.0 False True 2539952.087293597 2004940.485295027 2848991.435699754 1.0 0.7893615376939482 1.12167132992475 21.276369852118513 -6.735409011640866 1.7033573480765267 0.8740103640972718 1.121683235485288 0.5842264498247112 0.08851625005466522 0.3261855359475584 1.8563684400626386 0.04113989065325822 0.10147257140072583 1.839039207740017e-07 6.735409011640866 0.24767287138801608 SEHPGLSIGDTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEHPGLSIGDTAK 13 0 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 32425300.0 3534100.0 16037100.0 12854100.0 False True 4633239.324273083 13644427.192126198 11524081.037233796 1.0 2.944900152393249 2.487262200521409 22.143589774256224 -10.108324495475621 5.227616106392024 0.9999625725177795 2.716081176459237 0.9493636631478107 0.18682991150972977 8.150086978283627e-05 1.3901802245929406e-05 0.18090119259249446 0.06029909465325537 7.792476558998521e-11 10.108324495475621 1.7161186039414575 SEHPGLSIGDTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEHPGLSIGDTAK 13 0 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 30890000.0 8268300.0 5733800.0 16887900.0 False True 8005827.342338594 8023336.241371987 12464452.363859776 1.0 1.0021870193153928 1.5569224554646426 22.932619071505048 -6.907764959356397 0.9108228833113349 0.9815865209658426 1.6252877035708426 0.9900502995087733 0.026136198359494354 0.1059147830529827 0.14692289354335036 0.02116430653022205 0.057556588680912554 1.2366165105693432e-07 6.907764959356397 0.643701182605 SEHPGLSIGDTAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEHPGLSIGDTAK 13 0 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 96583800.0 5701100.0 88305000.0 2577700.0 False True 8648985.506238973 72546282.81988584 2068216.4651539547 1.0 8.387837251843507 0.2391282149405893 23.04409948924667 -6.66804677080352 1.9444617341770432 5.7237947864638565 0.27267545423609096 0.2701750497824985 3.139672726229052 0.46574474747333056 3.3930927966169304 1.300815549160884 3.4841200872970455 2.1475991786564926e-07 6.66804677080352 -5.451119332227766 SEHPGLSIGDTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEHPGLSIGDTAK 13 0 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 31522600.0 3534100.0 11820900.0 16167600.0 False True 4840752.275461419 11298613.551511085 12349145.862173999 1.0 2.33406150708964 2.5510799064793876 22.206799835779115 -10.475989923985324 0.3768648741706143 7.691125335518051e-21 2.579567068450149 0.9991999788003961 0.019397085131554248 1.9495212062016976 0.17843898195040744 1.9453553619906396 0.059082791424565094 3.3420279373547816e-11 10.475989923985324 2.579567068450149 SEHPGLSIGDTAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEHPGLSIGDTAK 13 0 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 13383970.0 8268300.0 3066300.0 2049370.0 False True 6875457.797796572 3049781.233287105 2477883.7917837296 1.0 0.4435750059093506 0.3603954623323897 22.713024346939324 -13.999999999999998 0.26761106487220343 5.240135607139373 0.33213956109538717 0.9995782176720145 0.005831466913971035 14.767302851916154 0.16374102058792103 34.016770213110085 0.034963674901655424 1.0000000000000041e-14 13.999999999999998 -4.907996046043986 SEHPGLSIGDTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEHPGLSIGDTAK 13 0 P26583;D6R9A6 P26583 HMGB2 High mobility group protein B2 0 11356300.0 5701100.0 2027600.0 3627600.0 False True 7380186.3354819305 1914762.277596355 2967414.022319245 1.0 0.2594463324578538 0.40207846894769106 22.81522581133912 -9.95847844597335 6.921982951644287 1.0000000413224779 0.33076240073856406 0.9670552171170745 0.05822932588719203 3.720430247820468e-08 5.583093128993978e-09 0.05638030571599427 0.018793434118497133 1.100326453120997e-10 9.95847844597335 -0.6692376405839138 SEIDLFNIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEIDLFNIR 9 0 P08758;D6RBL5;D6RBE9 P08758 ANXA5 Annexin A5;Annexin 0 13157000.0 3140700.0 4569300.0 5447000.0 False True 4117488.114582066 3887578.250991899 4883396.69131347 1.0 0.9441625920483068 1.1860135488962171 21.973333054841497 -6.845934678148529 1.2544615726020982 0.9702753875602496 1.1949539630097497 0.9341883363935028 0.02652417910816468 0.16198801214377975 0.49258212209629343 0.016560480419841848 0.03823738664761683 1.4258220341143656e-07 6.845934678148529 0.2246785754495001 SEIDLFNIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEIDLFNIR 9 0 P08758;D6RBL5;D6RBE9 P08758 ANXA5 Annexin A5;Annexin 0 8455300.0 3031900.0 1945900.0 3477500.0 False True 2935653.9940781514 2722908.0177344456 2566638.4272362045 1.0 0.9275302958819873 0.8742986852039337 21.48525050670013 -6.97449768731869 0.10504918682368147 1.1210920627093546 0.6793826026431439 0.9999996738531814 2.884910028290047e-05 0.07486829955863543 0.003094105964735393 0.004498279022072868 0.008420653395403 1.0604795855653987e-07 6.97449768731869 -0.4417094600662107 SEIDLFNIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEIDLFNIR 9 0 P08758;D6RBL5;D6RBE9 P08758 ANXA5 Annexin A5;Annexin 0 13602700.0 3140700.0 3337000.0 7125000.0 False True 4301901.664226163 3189560.3060166757 5442221.743981155 1.0 0.7414303150024285 1.265073488136116 22.03654311636439 -6.77238791495802 1.5649506679218999 0.8521528979860146 1.2683173790450282 0.7398028099719964 0.1090491505693451 0.2625498678578049 1.2692493813444292 0.05491093166351778 0.13044596049605617 1.6889316917647816e-07 6.77238791495802 0.4161644810590136 SEIDLFNIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEIDLFNIR 9 0 P08758;D6RBL5;D6RBE9 P08758 ANXA5 Annexin A5;Annexin 0 6399400.0 3031900.0 1927900.0 1439600.0 False True 2521159.1859438363 1917514.0200418108 1740613.7040416582 1.0 0.7605684046975236 0.6904021426913713 21.265655782134406 -13.999999999999998 0.17207023025631585 2.2141437753937296 0.6298521093736764 0.9995098798132485 0.0029342517275457993 12.112343266989944 0.13139681960379937 4.909774411532822 0.056145158430514645 1.0000000000000041e-14 13.999999999999998 -1.5842916660200532 SEIEYYAMLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEIEYYAMLAK 11 0 P62888;E5RI99 P62888 RPL30 60S ribosomal protein L30 0 14583300.0 3240600.0 4239400.0 7103300.0 False True 4248457.982015043 3606898.0450517666 6368318.655664948 1.0 0.8489899300689366 1.4989717875577189 22.018507865778744 -6.8455244198457805 1.2564683349387615 0.9196263422259685 1.5228006446548872 0.9335427171287142 0.07159933870974203 0.1624463356318007 0.4957621425780352 0.04463704616682919 0.10304144663271395 1.427169579914576e-07 6.8455244198457805 0.6031743024289187 SEIEYYAMLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEIEYYAMLAK 11 0 P62888;E5RI99 P62888 RPL30 60S ribosomal protein L30 0 12000700.0 3149200.0 1650400.0 7201100.0 False True 3049230.369784929 2309413.326722302 5314915.881630666 1.0 0.7573758118135205 1.7430352046524915 21.540013719603387 -6.8415965471253255 1.2749811277984313 0.8709465451991782 1.7764882539845244 0.9271624798515853 0.11316890568215891 0.16694126402279064 0.5264619916755159 0.06958189492300532 0.16037640562610897 1.440135820984269e-07 6.8415965471253255 0.9055417087853461 SEIEYYAMLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEIEYYAMLAK 11 0 P62888;E5RI99 P62888 RPL30 60S ribosomal protein L30 0 10899600.0 3240600.0 3200400.0 4458600.0 False True 4438737.393922153 3058995.745692473 3405570.507749381 1.0 0.6891589824352023 0.7672385648253351 22.081717927301636 -10.017701305330567 5.688938132199852 1.000000701479339 0.728198773630165 0.9417154922999111 0.03187585603127269 2.8358246374010874e-07 4.8990430907554896e-08 0.030863744449591585 0.010287888296215032 9.600607053492363e-11 10.017701305330567 -0.271801927849174 SEIEYYAMLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEIEYYAMLAK 11 0 P62888;E5RI99 P62888 RPL30 60S ribosomal protein L30 0 6503100.0 3149200.0 1609100.0 1744800.0 False True 2618699.3332149275 1600431.4589186574 2109629.612956297 1.0 0.6111551023132686 0.8056020735936664 21.320418995037663 -10.131895583781308 5.187550995173 1.0000091513131957 0.7083785879531699 0.7499369315212314 0.07938264361213683 8.402049693107575e-06 1.4060450474218355e-06 0.07686432535387992 0.025620638057160947 7.380816637272227e-11 10.131895583781308 -0.2916305633600258 SEILDESEDYRDTVVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEILDESEDYRDTVVKR 17 2 Q8NE01 Q8NE01 CNNM3 Metal transporter CNNM3 1 2823800.0 1423500.0 1400300.0 0.0 True False 1183703.32174249 1392756.3059622115 0.0 1.0 1.1766092739454188 0.0 20.174876104780534 -6.924913162956122 1.2497649491994363 1.0936431155138022 7.439696632819834e-19 0.9616667363430912 0.10143297721644838 0.11960315846610395 0.37347937697665856 0.06687688361397155 0.12998001843518406 1.1887398918400162e-07 6.924913162956122 -1.0936431155138022 down SEIPTK(ub)DVPIVHTETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEIPTKDVPIVHTETK 16 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6 P11171 EPB41 Protein 4.1 1 8079400.0 2215800.0 3670000.0 2193600.0 True False 2904935.257837725 3122450.3055479582 1966627.3144970154 1.0 1.0748777609151055 0.6769952305101854 21.470074580032367 -6.858029072243974 1.195626738865157 1.0404326332651126 0.6584381210836774 0.9512017161538349 0.03813733027641111 0.14884711251080235 0.4054454618388095 0.024897212698140412 0.05799567169385332 1.3866630007193508e-07 6.858029072243974 -0.3819945121814352 SEIPTK(ub)DVPIVHTETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEIPTKDVPIVHTETK 16 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6 P11171 EPB41 Protein 4.1 1 8994600.0 2642900.0 2970800.0 3380900.0 True False 2559002.5861503193 4157055.9325173404 2495340.865174084 1.0 1.6244828961939741 0.9751224475814204 21.287150174702454 -6.655012678877248 1.9903237965592673 1.4035977634649304 0.9778280867144354 0.21479072289595447 0.26620781463749693 0.4963375294572787 3.774136003153242 0.1082538276652516 0.29501827095061434 2.2130301010330074e-07 6.655012678877248 -0.42576967675049493 SEIPTK(ub)DVPIVHTETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEIPTKDVPIVHTETK 16 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6 P11171 EPB41 Protein 4.1 1 19465900.0 2860600.0 3209400.0 13395900.0 True False 4339739.337872899 2636657.4948433507 10748194.493368452 1.0 0.6075612587680658 2.476691261055468 22.049176960553467 -6.851884302156249 1.2259998796865696 0.7902000052073205 2.5541563145515527 0.94299813960611 0.1921291112933522 0.15539657787136485 0.44853135245074327 0.12256661480096766 0.28398272894124416 1.4064221508965998e-07 6.851884302156249 1.7639563093442323 up SEIPTK(ub)DVPIVHTETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEIPTKDVPIVHTETK 16 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6 P11171 EPB41 Protein 4.1 1 6079770.0 2215800.0 2209370.0 1654600.0 True False 3035041.139743475 2111752.7279904312 1263817.5575566604 1.0 0.6957904788628068 0.4164087072847651 21.53328464155526 -7.1247954539290275 0.21499792268252926 1.146757966729919 1.9814670684456054e-13 0.9999894715658517 0.0007732749338984296 0.0795157803625472 0.008460912940929623 0.010344982634746928 0.031860846258073436 7.502474812433633e-08 7.1247954539290275 -1.146757966729721 down SEIPTK(ub)DVPIVHTETK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEIPTKDVPIVHTETK 16 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6 P11171 EPB41 Protein 4.1 1 21741900.0 2860600.0 8768100.0 10113200.0 True False 3703103.090856079 8280147.52722065 8272701.370194906 1.0 2.236002434732773 2.233991646255366 21.820303282645916 -10.021097735502755 4.9015789736275 0.9999803439504894 2.2349970405094846 0.9999980116955254 0.0008209010209069572 283477.02862837043 0.014748009433715424 62.88864333584397 0.00028101624468600625 9.525817667920728e-11 10.021097735502755 1.2350166965589953 SEK(ub)CPVDNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEKCPVDNVK 10 1 Q6Q0C0;Q6Q0C0-2 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 3575740.0 650040.0 1014100.0 1911600.0 True False 852208.7349963137 862800.2329308392 1713805.9693620037 1.0 1.0124282907456603 2.0110166664384366 19.700847313410442 -6.909618193766851 0.898349373626565 0.9687045588579477 2.139010361981518 0.9907757361602467 0.04549516332245465 0.10467209354468766 0.1401497791122336 0.03717684603767359 0.10235305674506466 1.2313508265194342e-07 6.909618193766851 1.1703058031235702 up SEK(ub)CPVDNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEKCPVDNVK 10 1 Q6Q0C0;Q6Q0C0-2 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 2435760.0 794420.0 653160.0 988180.0 True False 769201.5719435221 913970.1941844025 729346.0132354496 1.0 1.1882063525625632 0.9481858069954661 19.553002185415203 -6.697630524466216 1.8401049793398672 1.117144034678115 0.94894886120012 0.4060232539388636 0.07947969642674342 0.4004492472445173 2.6345962239295306 0.034486584971743166 0.08892484133831725 2.0061780552476964e-07 6.697630524466216 -0.16819517347799495 SEK(ub)CPVDNVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEKCPVDNVK 10 1 Q6Q0C0;Q6Q0C0-2 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 9596300.0 1131600.0 4684900.0 3779800.0 True False 1716719.9310413839 3848842.9917092323 3032720.8732548063 1.0 2.241974897661074 1.7665787053658308 20.711223263844776 -10.312871383104577 5.251843019942695 0.9997527354833786 2.004276801513536 0.8561199960911092 0.19407968279785526 0.0005620284977923935 7.353336492827723e-05 0.18796140370588074 0.06263894827606714 4.8655127717261254e-11 10.312871383104577 1.0045240660301573 SEK(ub)CPVDNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEKCPVDNVK 10 1 Q6Q0C0;Q6Q0C0-2 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 4760180.0 650040.0 901840.0 3208300.0 True False 890377.3546704781 861993.7268139281 2450565.6170125925 1.0 0.9681217994733765 2.7522775642912976 19.764057374933333 -6.902832798757431 0.943181318991511 0.9314761633640158 2.9507154656214793 0.9879238327245398 0.09161080699166739 0.10935018193391115 0.16589142770854134 0.07244079710536984 0.1913047294180804 1.250740466473269e-07 6.902832798757431 2.0192393022574633 up SEK(ub)CPVDNVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEKCPVDNVK 10 1 Q6Q0C0;Q6Q0C0-2 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 3159120.0 794420.0 360200.0 2004500.0 True False 660595.4287732122 358259.5311058978 2423631.682239166 1.0 0.5423282019544389 3.66885929976851 19.33340746084948 -6.8697010539447225 1.1355985403962523 0.7415888678741398 3.850987866763871 0.96438791265187 0.2601778709360372 0.13714589550680178 0.33072920025039926 0.17783184168572652 0.42083144704057457 1.3498917591381842e-07 6.8697010539447225 3.109398998889731 up SEK(ub)CPVDNVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEKCPVDNVK 10 1 Q6Q0C0;Q6Q0C0-2 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 7074500.0 1131600.0 3041800.0 2901100.0 True False 1464878.507170785 2872521.156042902 2373129.567799751 1.0 1.960927914486771 1.6200180125402552 20.482349585937225 -10.184456733510741 4.633234599728201 0.9998683918166488 1.7904729635206555 0.8775798028260445 0.13917588469629036 0.0001892364220862921 3.33093110960954e-05 0.13477863258678968 0.04491882363175248 6.53948076188372e-11 10.184456733510741 0.7906045717040068 SEK(ub)EPLHVVATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEKEPLHVVATK 12 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 3343700.0 1029200.0 1152000.0 1162500.0 True False 1349291.1667869769 980126.0904608304 1042215.6514874084 1.0 0.726400731426096 0.7724171603147767 20.363770273839396 -10.32199777374533 5.678113414604956 1.0000354153898623 0.7494089458704472 0.9753334106250602 0.018786128427062537 8.423556032619215e-06 1.0058742826425944e-06 0.0181921573002418 0.006063196878142925 4.764334290640024e-11 10.32199777374533 -0.25062646951941514 SEK(ub)EPLHVVATK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEKEPLHVVATK 12 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 6198800.0 1350600.0 1795800.0 3052400.0 True False 1307725.9422810616 2512872.3049732866 2252884.869962844 1.0 1.9215588096310858 1.7227500022161717 20.31862879889194 -10.193784135831777 4.639123611353012 0.9998518324676627 1.8221544059289794 0.9579868470195487 0.08116335578260522 0.00012557202035783901 2.182282492819415e-05 0.07860017089434905 0.02619536043527485 6.400528919156687e-11 10.193784135831777 0.8223025734613166 SEK(ub)EPLHVVATK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEKEPLHVVATK 12 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 37912600.0 2562900.0 4199700.0 31150000.0 True False 3888106.673087626 3450230.722594129 24993188.846470002 1.0 0.8873806746290295 6.428112947483098 21.89063637021832 -6.902263208714652 0.946867294725808 0.7837227733458408 7.0371556095498295 0.9876585397840014 0.287260948768769 0.1097579124056125 0.16818087057280398 0.22653579743132699 0.5963780773348492 1.2523819257198042e-07 6.902263208714652 6.253432836203989 up SEK(ub)EPLHVVATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEKEPLHVVATK 12 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 3380060.0 1029200.0 874860.0 1476000.0 True False 1409723.053084205 836205.7924248578 1127399.1991742002 1.0 0.5931702617726221 0.7997309802855717 20.426980335362288 -10.269709165346086 4.7672945127319535 1.0001001645896128 0.6964506210285816 0.7422281621745569 0.08432806021177355 8.980628754723029e-05 1.3756969378508755e-05 0.08167713621381659 0.02721676440124848 5.373915517251369e-11 10.269709165346086 -0.30364954356103124 SEK(ub)EPLHVVATK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEKEPLHVVATK 12 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 5895900.0 1350600.0 2517800.0 2027500.0 True False 1123083.7417249067 2504236.111655828 2451440.8758991864 1.0 2.2297857395831016 2.1827765684988907 20.099034074326216 -10.139962396120465 6.369167157584266 0.9999959859033601 2.206281154040999 0.9988622809831795 0.01919141373126397 1.0942593758105402e-06 1.4776926799822626e-07 0.01858206812468278 0.006194002147611785 7.24498688898669e-11 10.139962396120465 1.2062851681376388 SEK(ub)EPLHVVATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEKEPLHVVATK 12 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 45382300.0 2562900.0 2769400.0 40050000.0 True False 3317724.5723117716 2615280.455501748 32761310.947702553 1.0 0.788275337057119 9.874632518055789 21.66176269231077 -6.901568114230086 0.9513272595253215 0.6383055370576558 10.859274137821306 0.9873297342845067 0.47662561267904974 0.11025932544121465 0.1709924548673286 0.3746338537184219 0.9826013618819974 1.2543879857092326e-07 6.901568114230086 10.22096860076365 up SEK(ub)FQEAGELYNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEKFQEAGELYNR 13 1 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 1 7060800.0 3174700.0 1382900.0 2503200.0 True False 4348472.383041614 1321798.9053612417 1911995.71502226 1.0 0.3039685638837349 0.439693654828936 22.052077240980474 -9.848703125859075 6.553943003099469 1.000000017887201 0.3718311093652911 0.9661714862256104 0.05540953635162691 1.444878230955845e-08 2.5615741274014674e-09 0.05365005447653667 0.017883350959214825 1.4167619162577162e-10 9.848703125859075 -0.62816890852191 SEK(ub)FQEAGELYNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEKFQEAGELYNR 13 1 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 1 5627000.0 1616600.0 1980400.0 2030000.0 True False 1344274.527522941 1969731.192121376 2454463.6143404897 1.0 1.4652745044205722 1.8258648543041762 20.358396364473272 -6.973972767825328 0.13246123116841546 0.4613038707490451 2.8391855984824836 0.9999991544013916 0.00031081392351870076 0.07503331759046367 0.003984948164577155 0.02208552642363462 0.04866266591666522 1.0617621322682911e-07 6.973972767825328 2.3778817277334383 SEK(ub)IVFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEKIVFAK 8 1 A0A087WUK8;P0CK97-2;P0CK97;P0CK96 A0A087WUK8 SLC35E2B;SLC35E2 Solute carrier family 35 member E2;Solute carrier family 35 member E2B 1 2907700.0 514060.0 497640.0 1896000.0 True False 497741.4466822177 696350.2471583167 1399380.7212192235 1.0 1.3990200169183429 2.811461112083471 18.9250369989508 -6.9476847354370115 0.5837081280896932 0.9833405825420571 3.297448654934163 0.999006846759436 0.02449122665808671 0.08442896509336076 0.03991414967696989 0.02555861698344179 0.1181108827107452 1.1280160123476516e-07 6.9476847354370115 2.3141080723921057 up SEK(ub)IVFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEKIVFAK 8 1 A0A087WUK8;P0CK97-2;P0CK97;P0CK96 A0A087WUK8 SLC35E2B;SLC35E2 Solute carrier family 35 member E2;Solute carrier family 35 member E2B 1 2692410.0 514060.0 744450.0 1433900.0 True False 427463.66671931447 740439.5000882439 1733721.8603954832 1.0 1.7321694397349536 4.055834437816436 18.705442274385078 -6.950178963968059 0.5568746328431298 0.9690977591579164 4.929363824186122 0.999215258529017 0.0364932854975742 0.08341394521666423 0.035665460975244014 0.03926805215105913 0.19303107446288284 1.1215561884526907e-07 6.950178963968059 3.9602660650282058 SELALSALGGCVFYLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SELALSALGGCVFYLK 16 0 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 0 25641600.0 7464400.0 6465200.0 11712000.0 False True 11324040.520736372 5311434.547161844 9397118.066448031 1.0 0.46904058118086417 0.8298379054048953 23.43288548096282 -10.117680900439524 5.553499886918477 1.000004413714912 0.6494392432928154 0.557276818628234 0.14729489081864522 8.049338874484323e-06 1.2789219323488106e-06 0.1426194579730208 0.04753922159346835 7.626391563030077e-11 10.117680900439524 -0.35056517042209656 SELALSALGGCVFYLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SELALSALGGCVFYLK 16 0 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 0 23104500.0 7464400.0 7886400.0 7753700.0 False True 9662812.945321301 7447514.907297241 6342606.159680432 1.0 0.770739840400543 0.6563933500080325 23.20401180305527 -13.999999999985816 0.09042660071055146 2.171761095556156 0.37220251008192395 0.9998404064797447 0.001804844365559948 12.159896279497728 0.08747635807368391 2.7349896133370173 0.25524078861433164 1.0000000000326604e-14 13.999999999985816 -1.799558585474232 SELELTLGK(ub)LEQVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SELELTLGKLEQVR 14 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 1 24915800.0 9716600.0 9254900.0 5944300.0 True False 12738556.695688257 7874104.995317652 5329240.857751912 1.0 0.6181316442217412 0.4183551547527949 23.602698490790832 -11.303993785054512 0.11207130357227685 2.081066790412909 1.6249887192633732e-14 0.9998336882521791 0.003111885973675096 3.916777398291414 0.07125742536408941 1.3475043030231957 0.286632190760107 4.965994279562192e-12 11.303993785054512 -2.0810667904128928 SELELTLGK(ub)LEQVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SELELTLGKLEQVR 14 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 1 54283100.0 10932900.0 13493900.0 29856300.0 True False 10585841.073866893 18882084.639758874 22036039.360199112 1.0 1.7837113279900634 2.08165219999374 23.335632564156096 -10.44982558775828 0.21004535723923365 2.2119610240821607e-17 2.3089263112282388 0.9993333415930701 0.011778574509264023 2.135508783704332 0.10556684805178719 1.2977575179312075 0.1709198193402272 3.549559105620472e-11 10.44982558775828 2.3089263112282388 SELELTLGK(ub)LEQVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SELELTLGKLEQVR 14 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 1 349553000.0 32345000.0 46178000.0 271030000.0 True False 49069729.73624383 37937175.10963925 217460801.70333093 1.0 0.7731278593453946 4.431669032460765 25.548329989637352 -6.892132205381443 1.0096631671540697 0.8133526759589831 4.759829224486217 0.9822290100295419 0.22312315253722823 0.11743102786485184 0.21186879778438394 0.16788955795822888 0.4219042142044309 1.2819402825032922e-07 6.892132205381443 3.946476548527234 up SELELTLGK(ub)LEQVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SELELTLGKLEQVR 14 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 1 36050700.0 9716600.0 7141100.0 19193000.0 True False 13309089.601241741 6825582.589540215 14660008.692242837 1.0 0.5128512012499628 1.1015034935879502 23.665908552313724 -6.686956487168045 1.877362681978617 0.6937204717225629 1.0993908119389502 0.3561778483873762 0.20615879686129335 0.4232331043295252 2.8897007347478563 0.08793047559450538 0.2298482155028764 2.0560965900903705e-07 6.686956487168045 0.40567034021638726 SELELTLGK(ub)LEQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SELELTLGKLEQVR 14 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 1 58819000.0 10932900.0 20568700.0 27317400.0 True False 9091190.75959147 20457892.330532737 33029342.038613297 1.0 2.2502984341131627 3.6331150574270357 23.116037839590373 -6.969827263538676 0.26228021555647985 0.6224232346750788 5.30213888055619 0.9999810036041765 0.004687192006014291 0.07635881690784879 0.009230563953696737 0.028447053124631083 0.13002989526760284 1.071945576522639e-07 6.969827263538676 4.679715645881111 SELELTLGK(ub)LEQVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SELELTLGKLEQVR 14 1 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 1 457648000.0 32345000.0 41193000.0 384110000.0 True False 41871240.115269534 38900573.33844284 314205921.3014239 1.0 0.9290523335671791 7.504098766514437 25.3194563117298 -6.9044637872398615 0.9326425375742753 0.7590922483411494 8.260327155842003 0.9886584288497586 0.32832117037386227 0.10819326870392311 0.1594798220088871 0.2616493643934352 0.6973323642916716 1.2460521324563437e-07 6.9044637872398615 7.501234907500853 up SELIEQVMK(ub)EEHKPQQNGISPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SELIEQVMKEEHKPQQNGISPR 22 2 Q92995;Q92995-2;H7C5J3 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 10674700.0 4213400.0 3062600.0 3398700.0 True False 4079647.923298559 4285512.151248011 2508478.511185533 1.0 1.0504612730853016 0.6148762242103792 21.960013221219885 -6.878052215434274 1.0906422116320502 1.0305353883067983 0.5851413366305529 0.9720783798348392 0.032506634177949516 0.12936764595706285 0.28285207661150136 0.022998862122929332 0.05535045504243705 1.3241823185469696e-07 6.878052215434274 -0.44539405167624535 SELIEQVMK(ub)EEHKPQQNGISPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SELIEQVMKEEHKPQQNGISPR 22 2 Q92995;Q92995-2;H7C5J3 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 11595200.0 4056300.0 2943400.0 4595500.0 True False 5556023.727385803 2813350.8554778183 3510137.5472933836 1.0 0.5063604825175115 0.6317715185397451 22.40562132978616 -10.14728165185973 7.811064517484705 1.0000000941396827 0.5690660005286573 0.9402737080913612 0.05119884106137881 8.397189606356058e-08 9.173341960384297e-09 0.04957307577426127 0.016524354897986725 7.123908752993344e-11 10.14728165185973 -0.4309340936110254 SELIEQVMK(ub)EEHKPQQNGISPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SELIEQVMKEEHKPQQNGISPR 22 2 Q92995;Q92995-2;H7C5J3 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 10583800.0 4213400.0 4537000.0 1833400.0 True False 3503628.7852685694 4512558.280476013 2216755.463316184 1.0 1.2879670070783782 0.6327027202872634 21.74041849665416 -6.787252479029959 1.5073349464719163 1.1615209283353776 0.6262551213376244 0.7922908985759678 0.12221568940838268 0.23946951116671014 1.0749044341235419 0.06383112661295728 0.1497461665667741 1.6321028417864988e-07 6.787252479029959 -0.5352658069977532 SELK(ub)ELLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SELKELLTR 9 1 P26447 P26447 S100A4 Protein S100-A4 1 14077500.0 5861300.0 4030400.0 4185800.0 True False 7684221.060909942 3429080.0303761503 3752693.5690288153 1.0 0.4462495291578831 0.4883635620686364 22.873467592608073 -10.56204718853839 6.26551111593794 1.0009604597107284 0.46730654561325974 0.9953341672339924 0.017192981940353933 0.00023104005339291984 1.614945975663322e-05 0.016673834116623657 0.005549011060552964 2.7412763006555795e-11 10.56204718853839 -0.5336539140974688 SELK(ub)ELLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SELKELLTR 9 1 P26447 P26447 S100A4 Protein S100-A4 1 22143600.0 5338800.0 9427600.0 7377200.0 True False 5169322.716311372 13192089.844284518 5444890.008743903 1.0 2.5519957967913216 1.0533082006203638 22.301543840613572 -6.6379891682357295 2.0513793067001775 2.0164400644196956 1.0594710039424187 0.14706140775665455 0.664383124343156 0.5384627324072508 4.328051491005046 0.26394934418703514 0.7358495034389286 2.301499218520343e-07 6.6379891682357295 -0.9569690604772769 SELK(ub)ELLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SELKELLTR 9 1 P26447 P26447 S100A4 Protein S100-A4 1 20428900.0 5861300.0 6885300.0 7682300.0 True False 8028381.005676696 6581084.679357689 5867898.961934928 1.0 0.8197274985709254 0.7308944303696925 22.936677654130964 -13.999999999990777 0.09255562141092004 1.9133399600964636 0.5177924171499636 0.9998302912037014 0.0014584653476960388 12.141183568878724 0.08901068596121414 2.1634876880035603 0.19104609891820995 1.0000000000212364e-14 13.999999999990777 -1.3955475429464999 SELK(ub)ELLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SELKELLTR 9 1 P26447 P26447 S100A4 Protein S100-A4 1 17109800.0 5338800.0 7290700.0 4480300.0 True False 4439448.748941907 7251423.552009364 5417110.015433348 1.0 1.6334062993153509 1.22022132065934 22.08194911604785 -10.129012725100122 4.283695319795481 0.9999296739062367 1.4268138097097725 0.5872447916610279 0.1686820613931366 58877289.146183625 7.32108547271004 46043.41941807706 0.05774435626252696 7.429973672898925e-11 10.129012725100122 0.4268841358035358 SELK(ub)ELLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SELKELLTR 9 1 P26447 P26447 S100A4 Protein S100-A4 1 23321300.0 8759800.0 7109200.0 7452300.0 True False 11339733.781472802 6713566.770510943 6096057.867055275 1.0 0.5920391871526799 0.537583860832359 23.434883435297913 -13.999999999999998 0.2838144418709326 4.395767571108182 0.5217975473049068 0.9996136467719524 0.004056001565240164 15.608380285515594 0.1688229229800449 30.834133475862235 0.021158118044742356 1.0000000000000041e-14 13.999999999999998 -3.8739700238032757 SELNK(ub)HIEDGMGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SELNKHIEDGMGR 13 1 Q8IWA4 Q8IWA4 MFN1 Mitofusin-1 1 4291870.0 751470.0 1074800.0 2465600.0 True False 1029308.7667131627 1027311.7821116945 1883276.0606259536 1.0 0.9980598779821481 1.829651239287235 19.973244388666227 -6.906372604131885 0.9200844433119816 0.9712059178259376 1.9291813603812409 0.989479037806231 0.04016293302995613 0.10686613754801717 0.15214142230824448 0.032303145934686556 0.08708162058801651 1.2405874854670675e-07 6.906372604131885 0.9579754425553033 SELNK(ub)HIEDGMGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SELNKHIEDGMGR 13 1 Q8IWA4 Q8IWA4 MFN1 Mitofusin-1 1 18549900.0 2421700.0 5963200.0 10165000.0 True False 3134938.388843661 5631342.677925914 8315074.301707784 1.0 1.7963168584002267 2.6523884269300884 21.580005659246815 -6.9702032248069745 0.25328336228657583 0.7390641713412006 3.7348197427451617 0.9999839252128442 0.002705221201139686 0.07623679890336979 0.008793804024445257 0.018676584264813476 0.0816134565766764 1.0710180132074576e-07 6.9702032248069745 2.995755571403961 SELNLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SELNLR 6 0 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 0 9250060.0 706960.0 4774100.0 3769000.0 False True 926831.4062103784 4061822.88929605 3379020.0348009 1.0 4.382483008321872 3.6457763646756565 19.821947406011457 -10.564811489821423 8.931848480873786 0.9996090748890584 4.014129686498701 0.9571163916046853 0.30075922784193815 0.002341610829807826 0.00011409094540343378 0.2912277726700329 0.09706962338750234 2.7238833823147296e-11 10.564811489821423 3.0145206116096426 SELNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SELNLR 6 0 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 0 8525000.0 2926400.0 1433600.0 4165000.0 False True 2833503.033830376 2006043.9561252375 3074061.552678303 1.0 0.707973110377593 1.0848979217512027 21.434155316465347 -6.6998828680572196 1.8315156539780877 0.8186408455422604 1.0837661487327457 0.4169446066744995 0.12327083250988484 0.39575154296456744 2.5808807052226244 0.05369937564627998 0.13810888296068247 1.9958005222919438e-07 6.6998828680572196 0.26512530319048533 SELNLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SELNLR 6 0 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 0 31270100.0 3175000.0 26643000.0 1452100.0 False True 4816707.123591712 21888348.487290844 1165091.7985219595 1.0 4.544255634743511 0.24188553894328876 22.199615773882773 -6.687879610900763 1.8741569089998447 3.226442991936523 0.2572047630242862 0.3604470888954594 1.499624041116577 0.4212307709871351 2.8669714371357053 0.6405461785080747 1.6723715647416222 2.0517308524027265e-07 6.687879610900763 -2.969238228912237 SELNLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SELNLR 6 0 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 0 7981860.0 706960.0 3383200.0 3891700.0 False True 968342.216875641 3233719.037253708 2972560.6120773964 1.0 3.3394382491009345 3.0697418332832496 19.88515746753435 -10.392737083612527 8.33720878684128 0.9999809256517908 3.204590041192092 0.9889003707802639 0.110103100701801 3.903700546910223e-05 2.8428955036398697e-06 0.1066077758525829 0.03553562294865611 4.048208909784623e-11 10.392737083612527 2.2046091155403014 SELNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SELNLR 6 0 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 0 4971920.0 2926400.0 1412700.0 632820.0 False True 2433431.2615013868 1405089.5047010055 765139.7361709106 1.0 0.5774108054460058 0.31442833347132726 21.214560591899623 -8.57759031278567 0.19445063641196503 1.3374474482571026 1.5878998898238162e-23 0.999719316568945 0.004731222647599841 0.19334023780677828 0.051492872233850254 0.16649412765958924 0.13086346997608908 2.6449026224297148e-09 8.57759031278567 -1.3374474482571026 down SELNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SELNLR 6 0 P06744;A0A2U3TZU2;P06744-2;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7ERC6;K7EPY4;K7EP41;K7ENA0;K7ELR7;A0A2R8YF08;K7ERK8;A0A0J9YXM3;K7EIL4;A0A0J9YXH9;A0A0J9YYI8 P06744 GPI Glucose-6-phosphate isomerase 0 7003100.0 3175000.0 2223000.0 1605100.0 False True 4110100.0886066025 2099288.0958259497 1312988.2697167888 1.0 0.5107632540738554 0.3194540866185853 21.970742095975222 -13.999999999999998 0.12981649074719706 3.3249126045205535 0.05091332955291747 0.9996464479799371 0.005388341990690169 11.936992809100964 0.11202663525198085 7.082423925033909 0.23880496406562485 1.0000000000000041e-14 13.999999999999998 -3.273999274967636 SELPLDPLPVPTEEGNPLLK(ub)HYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SELPLDPLPVPTEEGNPLLKHYR 23 1 Q15758;M0QXM4;Q15758-3;Q15758-2 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 1 16186400.0 4980600.0 6149700.0 5056100.0 True False 4822493.579242607 8605307.280261839 3731755.7302513276 1.0 1.7844103136397207 0.7738228509652917 22.201347886768897 -6.6994785893505675 1.8324523101168764 1.4873207471868064 0.7768262681720667 0.41526848798209404 0.3311388293747836 0.3965856990270058 2.5885641856188357 0.14417651223801792 0.3710608811585121 1.997659250300956e-07 6.6994785893505675 -0.7104944790147397 SELVHK(ub)ETAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SELVHKETAAR 11 1 O60239;O60239-2;C9JK30;C9JNW0 O60239 SH3BP5 SH3 domain-binding protein 5 1 10730200.0 2917500.0 6648200.0 1164500.0 True False 2824885.5594587596 9302860.929904994 859482.5157488317 1.0 3.2931815233206816 0.30425392379913124 21.429760992198702 -6.701737105108786 1.8246622987697456 2.4215717927892286 0.31287160556746285 0.4257682887384143 0.9676818136821672 0.3919562242218444 2.538247545553471 0.4228951262841455 1.0852537013199073 1.9872975397592128e-07 6.701737105108786 -2.108700187221766 SELVHK(ub)ETAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SELVHKETAAR 11 1 O60239;O60239-2;C9JK30;C9JNW0 O60239 SH3BP5 SH3 domain-binding protein 5 1 6345800.0 1561600.0 3644200.0 1140000.0 True False 2369061.3682522303 2993864.0377354394 914678.5003202492 1.0 1.2637342695534122 0.38609320660825736 21.17588414001141 -6.826120394266767 1.34505334286924 1.1413414820288639 0.3642757629693822 0.8979219437327578 0.11747220358239031 0.18563795696288424 0.6581676861162161 0.06859779952821876 0.15792010723776628 1.4923806373879764e-07 6.826120394266767 -0.7770657190594816 down SELVHK(ub)ETAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SELVHKETAAR 11 1 O60239;O60239-2;C9JK30;C9JNW0 O60239 SH3BP5 SH3 domain-binding protein 5 1 5736090.0 1545800.0 3196800.0 993490.0 True False 2117324.0336742764 3055554.8055960773 758848.1235688194 1.0 1.443121013600196 0.35839961739439574 21.01381064452778 -6.795801882104501 1.4730922350414128 1.2458078922454898 0.3449506647939693 0.8195642506465453 0.18915327487032046 0.2268128062206776 0.9720844352614181 0.1010397815297047 0.23559715727618522 1.6002878867571223e-07 6.795801882104501 -0.9008572274515205 down SELVHK(ub)ETAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SELVHKETAAR 11 1 O60239;O60239-2;C9JK30;C9JNW0 O60239 SH3BP5 SH3 domain-binding protein 5 1 10615070.0 2917500.0 7230100.0 467470.0 True False 2426030.517164533 7191150.016237519 565215.8156629304 1.0 2.9641630496232607 0.23297968086713788 21.210166267632978 -6.713703992501496 1.7816491819084463 2.202957885349416 0.238590240856916 0.4826950557011699 0.82723338789441 0.3677514008825978 2.277666403541981 0.36914814242561234 0.9337453102246337 1.933285561576858e-07 6.713703992501496 -1.9643676444925 SELVNWYLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SELVNWYLK 9 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 29377800.0 8668100.0 8596700.0 12113000.0 False True 11363963.041999813 7314105.869674138 10859662.956100622 1.0 0.6436228138583432 0.9556228681811654 23.437962708911265 -10.200386318608912 7.52975863422685 1.0000001909634242 0.7996228410197542 0.35481927813673064 0.12737348880192456 4.0825254205366507e-07 4.344347511870138e-08 0.12332896599608728 0.041109616739849225 6.303963376196548e-11 10.200386318608912 -0.20037734994366996 SELVNWYLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SELVNWYLK 9 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 23955200.0 8278500.0 4013700.0 11663000.0 False True 8015703.548921786 5616391.341168993 8608110.41749989 1.0 0.7006735350042317 1.0739057856821301 22.93439772251684 -6.693193903131711 1.8552864488054648 0.8129048108272422 1.0726604765911822 0.38534839962854506 0.12651314635739352 0.40982136799762664 2.737455048944518 0.054504670540999105 0.14135374164995562 2.0267776049342815e-07 6.693193903131711 0.25975566576394005 SELVNWYLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SELVNWYLK 9 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 24828600.0 5085600.0 19743000.0 0.0 False True 7715227.007161589 16219707.397236938 0.0 1.0 2.1022981413484194 0.0 22.879277175541848 -6.768893366445399 1.6092122835285712 1.636686418570676 2.5188405970338922e-11 0.7077969422265153 0.4641222398737511 0.27247142589253404 1.39729375681796 0.2285182317250981 0.537887157761721 1.7025764955088168e-07 6.768893366445399 -1.6366864185454877 SELVNWYLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SELVNWYLK 9 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 24988800.0 8668100.0 6793100.0 9527600.0 False True 11872930.816594647 6492958.380222322 7277377.107081377 1.0 0.5468707331425865 0.6129385591053792 23.501172770434156 -10.545987485690922 6.315161282516264 1.0005704080241302 0.5799046461240356 0.9817877679336803 0.026972077003974148 0.00021689302655403524 1.5592909959881167e-05 0.026149255487660453 0.008705200420751322 2.844543072519559e-11 10.545987485690922 -0.42066576190009464 SELVNWYLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SELVNWYLK 9 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 17344000.0 8278500.0 4548300.0 4517200.0 False True 6883939.549733183 4523797.405133136 5461725.634827022 1.0 0.6571524012450799 0.7934011615541736 22.714802997951118 -10.043948639170535 4.929948585220963 1.000005316322373 0.7252767819656964 0.8442564582481416 0.055623323483411154 77007531.17804809 19.212669645024327 4647.357982053499 0.01904134312061732 9.03756348050603e-11 10.043948639170535 -0.27472853435667655 SELVNWYLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SELVNWYLK 9 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 18720200.0 5085600.0 7172300.0 6462300.0 False True 6583409.452163077 6773155.200041593 5286227.708797465 1.0 1.0288218056703389 0.8029620134079002 22.650403497634297 -6.874856180158336 1.108037798172872 1.0168943227135583 0.7884512072802274 0.9692963464091602 0.017587297814818485 0.1322863677426139 0.30062386450521855 0.012277912350199009 0.029340939746597804 1.3339631108135175e-07 6.874856180158336 -0.22844311543333085 SELVQK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SELVQKAK 8 1 P31946;Q4VY19;A0A0J9YWE8;Q4VY20;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 22629000.0 12786000.0 6107300.0 3735700.0 True False 16762569.81980015 5196114.6460689455 3349165.599364741 1.0 0.3099831769190445 0.19980024753774125 23.99874000549682 -13.999999999999998 0.2582079445464752 6.004410635507594 0.15883247549145454 0.9995586988680965 0.007438971825132154 14.33857263411649 0.16079552316323725 37.401109024580755 0.048629348107418535 1.0000000000000041e-14 13.999999999999998 -5.84557816001614 SELVQK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SELVQKAK 8 1 P31946;Q4VY19;A0A0J9YWE8;Q4VY20;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 16220300.0 6107100.0 6282700.0 3830500.0 True False 5913233.453357529 8791414.873847684 2827177.1374632055 1.0 1.4867356317305427 0.47811018451468995 22.495515804883123 -6.775481064997455 1.5533029889420085 1.2772288486546115 0.4712043084608335 0.7510851443752307 0.2054790808208393 0.25768740351573505 1.2276528576839887 0.10422161395884735 0.2468821529758485 1.6769454480616766e-07 6.775481064997455 -0.806024540193778 down SELVQK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SELVQKAK 8 1 P31946;Q4VY19;A0A0J9YWE8;Q4VY20;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 19051800.0 12786000.0 3926400.0 2339400.0 True False 17513329.728657864 3752918.6651315214 1786881.9014553686 1.0 0.21428927127378003 0.10202982123561642 24.061950067019712 -13.999999999999998 0.2740751460475063 7.199301115059079 0.06621410982986688 0.9995921544585609 0.008067670696110302 15.086807875533738 0.16576486842609423 52.23951012019946 0.045693263569976134 1.0000000000000041e-14 13.999999999999998 -7.133087005229212 SELVQK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SELVQKAK 8 1 P31946;Q4VY19;A0A0J9YWE8;Q4VY20;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 15683800.0 6107100.0 5198200.0 4378500.0 True False 5078324.24040292 5170196.264838085 5294024.106103369 1.0 1.018091011933471 1.0424746147527073 22.2759210803174 -6.966974510807361 0.3223840536842776 0.9967527263263551 1.0646021336837317 0.9999481319899552 0.00012520604326983305 0.07729734600120383 0.012531251516612144 0.00036610483857230265 0.002140366550081132 1.0790100485879954e-07 6.966974510807361 0.06784940735737655 SEMCGQK(ub)FELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEMCGQKFELK 11 1 Q12980;B7Z6Q0;B1B1F5 Q12980 NPRL3;C16orf35 Nitrogen permease regulator 3-like protein 1 5677060.0 1300200.0 816460.0 3560400.0 True False 1683134.530773642 771023.2832739796 2912443.7327890187 1.0 0.4580877340325159 1.730368951227168 20.6827190633558 -6.790960098901668 1.4924792130825788 0.6975146325405347 1.744267721833492 0.8044616581744145 0.2305185181670136 0.23390111743960804 1.029254166057478 0.12156698890460442 0.2844222466114834 1.6182287066668831e-07 6.790960098901668 1.0467530892929573 SEMEVQDAELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEMEVQDAELK 11 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 5858320.0 1448300.0 451120.0 3958900.0 False True 1402324.5092593383 631254.5685597216 2921945.325545773 1.0 0.45014870979694244 2.0836441966553436 20.419388808634242 -6.815912919852863 1.3894859691557395 0.7023591310473404 2.116269758190253 0.8747274667490978 0.24019568807130445 0.1988399539707366 0.7554084540874225 0.13588121646282053 0.3135732937089345 1.5278723803754671e-07 6.815912919852863 1.4139106271429127 up SEMEVQDAELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEMEVQDAELK 11 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 6261900.0 1678100.0 2690700.0 1893100.0 False True 2172333.530296297 2540960.179684609 1548575.2248463342 1.0 1.169691552538911 0.712862552296523 21.050814194364822 -6.806117696559721 1.4306614737653491 1.0929163834435094 0.7055522904051438 0.8494622824486773 0.07315312382628553 0.21215479088906666 0.8565156140100095 0.0402126829396265 0.09319992644239111 1.5627240771103938e-07 6.806117696559721 -0.3873640930383656 SEMEVQDAELK(ub)ALLQSSASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEMEVQDAELKALLQSSASR 20 1 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 11524100.0 4489500.0 2508900.0 4525700.0 True False 4346983.279928056 3510716.8537406577 3340283.401910254 1.0 0.8076214302344318 0.7684141361513442 22.05158311582325 -13.999999999999998 0.2235932119662583 2.179520844309159 0.7481507456033324 0.9995017431591201 0.002259016184966998 13.09984375628701 0.14976892040421264 6.8355511361420165 0.02119535292182127 1.0000000000000041e-14 13.999999999999998 -1.4313700987058269 SEMEVQDAELK(ub)ALLQSSASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEMEVQDAELKALLQSSASR 20 1 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 10342300.0 4489500.0 2624000.0 3228800.0 True False 3733218.168572467 2609863.99117678 3903927.151715557 1.0 0.6990922773138537 1.0457270310586662 21.831988391257525 -6.677155960227122 1.9117857752047829 0.8091308342301973 1.0443865434751702 0.31124225393558114 0.12761147084268082 0.44487524128297856 3.141101424357314 0.053607126642733594 0.14191316680148675 2.1030230839636905e-07 6.677155960227122 0.23525570924497297 SEMTPEELQK ddPTM_RPMI8226_Bortezomib_2h_R1 2 SEMTPEELQK 10 0 P62316;K7ERG4 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 0 18289080.0 5086200.0 2538980.0 10663900.0 False True 4924741.365045124 3552807.95460579 7870704.6798574105 1.0 0.7214202109826404 1.5981965541829615 22.23161652918972 -6.821253612579215 1.3664959932522611 0.8500365357194396 1.6178490228956712 0.887234238805668 0.12283257083166829 0.19185507123556012 0.7036125273877859 0.07063179361857978 0.1627386243946182 1.5091985783246392e-07 6.821253612579215 0.7678124871762316 SEMTPEELQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEMTPEELQKR 11 1 P62316;K7ERG4 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 1 6923500.0 3012700.0 2610000.0 1300800.0 True False 3949678.8750283048 2220598.1737003187 1166205.6941546858 1.0 0.5622224600941527 0.2952659522595564 21.913303930401977 -8.641328763554696 0.2017729116194948 1.3336272901937583 9.601460411668053e-09 0.9996622782552562 0.005338761062401024 0.22757975964836166 0.05561537806992471 0.17612314518681116 0.12980836758452033 2.2838692459554905e-09 8.641328763554696 -1.3336272805922977 down SEMTPEELQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEMTPEELQKR 11 1 P62316;K7ERG4 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 1 9196100.0 3546600.0 3087200.0 2562300.0 True False 3434015.1243106904 4319935.059535322 1891156.762647688 1.0 1.2579837022128615 0.5507129975227758 21.711464962688677 -6.807994365545557 1.4229036336323517 1.1409361755223633 0.5388941127646583 0.8545363579733061 0.11146004906190135 0.20954880989226846 0.8365499547760996 0.061599587179397626 0.14262924837483903 1.5559858185397515e-07 6.807994365545557 -0.602042062757705 SEMTPEELQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEMTPEELQKR 11 1 P62316;K7ERG4 P62316 SNRPD2 Small nuclear ribonucleoprotein Sm D2 1 5881690.0 3012700.0 1897300.0 971690.0 True False 4126576.605156229 1813471.012467918 742196.8345837264 1.0 0.4394613710071333 0.17985776240197227 21.976513991924868 -9.442953285405808 0.23459048178000882 1.4305146036373897 1.4662294676532124e-15 0.9992223952912327 0.009543902038946443 0.8538312447107788 0.09197479465935139 0.3912146269088421 0.12006048052177486 3.6061743050718364e-10 9.442953285405808 -1.4305146036373881 SENLGQGDKPDYFSSVATVVYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SENLGQGDKPDYFSSVATVVYLR 23 1 P27694 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 0 17070700.0 5535700.0 0.0 11535000.0 False True 8398061.613879258 0.0 9255102.194029905 1.0 0.0 1.1020521900832734 23.001624942125822 -10.667026274471807 4.270856930296885 1.0169878275031805 0.5510260950459909 0.1811987199354309 0.44991092260422666 0.07347104449214092 0.005728102895934766 0.4397919074277737 0.14520812587680773 2.1526514970760203e-11 10.667026274471807 -0.46596173245718964 SEPIPESNDGPVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEPIPESNDGPVK 13 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 25192880.0 981080.0 15858000.0 8353800.0 False True 1286205.3807922364 13492048.213999841 7489428.911307967 1.0 10.489808560503326 5.822887248920436 20.29468959938701 -9.697613655129802 9.49204100054925 1.0003714367253194 8.15634790471188 0.7581717916156382 1.90526265925187 0.0 0.0 1.8447626044261816 0.6149208773016931 2.006255982900987e-10 9.697613655129802 7.155976467986561 SEPIPESNDGPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEPIPESNDGPVK 13 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 23469200.0 5779900.0 2477300.0 15212000.0 False True 5596420.238257301 3466498.8089488377 11227520.849782065 1.0 0.6194136003675609 2.0061968851142353 22.416072868654297 -6.8335401421533 1.3119613130029626 0.7970845296429149 2.0463025076894947 0.9127850100122561 0.17277508560004168 0.17647901728062793 0.5928090775108771 0.10335817210826138 0.2378723321541792 1.4671004754816974e-07 6.8335401421533 1.24921797804658 up SEPIPESNDGPVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEPIPESNDGPVK 13 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 24984480.0 981080.0 9424400.0 14579000.0 False True 1343811.7886901032 9007998.84567683 11135740.463929988 1.0 6.703318814056161 8.286681630308278 20.3578996609099 -9.17592020420452 0.46215099364997503 1.1250945441709881e-14 8.378077922004067 0.9975324124376823 0.1554455971021568 0.5817604438985531 0.18340949563062517 1.5139273792798376 0.34388881079067424 6.669292972844617e-10 9.17592020420452 8.378077922004056 SEQFPSK(ub)VGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEQFPSKVGGR 11 1 F5H4V9;Q16342;J3QK82;A0A087WYJ3;Q16342-4;F5GWT2 F5H4V9 PDCD2 Programmed cell death protein 2 1 5773890.0 653590.0 1521900.0 3598400.0 True False 632842.1432070782 2129602.6066036555 2655871.0903139473 1.0 3.3651403109966527 4.196735503193084 19.271486151635912 -9.382551938181109 0.32861594078386897 3.8220914178778335e-22 4.456227954976491 0.9984812078663113 0.05277519539643761 0.7623829411362991 0.12918270966441325 1.1454282799712672 0.26071456052298847 4.144270188843473e-10 9.382551938181109 4.456227954976491 SEQFPSK(ub)VGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEQFPSKVGGR 11 1 F5H4V9;Q16342;J3QK82;A0A087WYJ3;Q16342-4;F5GWT2 F5H4V9 PDCD2 Programmed cell death protein 2 1 14447200.0 1190100.0 2580100.0 10677000.0 True False 1805468.7079642517 2119660.9965866874 8566686.270104665 1.0 1.1740225611424204 4.744854470374064 20.783941985314957 -6.9170449751234635 0.8463587541736018 0.9125129147225959 5.283276105240859 0.9933198386961153 0.14105244104428874 0.09994171080110384 0.11485593279641067 0.11966650454947016 0.3489264042733925 1.2104727716505327e-07 6.9170449751234635 4.370763190518264 up SEQFPSK(ub)VGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEQFPSKVGGR 11 1 F5H4V9;Q16342;J3QK82;A0A087WYJ3;Q16342-4;F5GWT2 F5H4V9 PDCD2 Programmed cell death protein 2 1 15158000.0 1190100.0 3547900.0 10420000.0 True False 1540607.9103781795 3350456.2461452466 8523666.918228736 1.0 2.1747624581018776 5.532664645436227 20.555068307407407 -6.952532640261901 0.5303117601383226 0.947159057660695 6.912784762117748 0.999385337603435 0.04761789349617368 0.08248443520389073 0.03187485193322258 0.05310045480839076 0.2776917864613961 1.1154943110161348e-07 6.952532640261901 5.965625704457053 SESHPSVYK(ub)VASGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SESHPSVYKVASGLK 15 1 O43196-3;O43196-2;O43196;O43196-4;A0A024RCV8;A0A0G2JK88;A0A140T982;A0A140T9J3;A0A0G2JK42;H7C2J4;A0A140T9X1;A2ABE9;A0A140T9A7 O43196-3 MSH5 MutS protein homolog 5 1 13525800.0 1958000.0 4208400.0 7359400.0 True False 2970429.1489740415 3457378.1396207255 5904811.36426039 1.0 1.1639322017880385 1.9878647387701058 21.50223994693958 -6.939690106302337 0.6624479487224909 0.9907006096637643 2.20803648189895 0.9981229337653906 0.018727588277845743 0.08790842729011694 0.05525723104053214 0.01818730541481078 0.0710116596892563 1.1489731864694753e-07 6.939690106302337 1.2173358722351857 SESNRFPLPFPFPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SESNRFPLPFPFPSK 15 1 B4DVT3;B4DJL6;Q96SY0-4;Q96SY0-3;Q96SY0;H3BRY6 B4DVT3 VWA9 von Willebrand factor A domain-containing protein 9 0 2776580.0 729690.0 983390.0 1063500.0 False True 956630.6563280127 836672.0452241965 953459.2218123516 1.0 0.874603003457706 0.9966847868666111 19.86760249932127 -10.699652353913878 7.281277743867093 1.0004184803975718 0.9356438951625754 0.2703521414775246 0.04983967937346509 0.0003407644784428191 1.4056313945701969e-05 0.0485685744837365 0.016085687349478957 1.996860131344061e-11 10.699652353913878 -0.06477458523499635 SESNRFPLPFPFPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SESNRFPLPFPFPSK 15 1 B4DVT3;B4DJL6;Q96SY0-4;Q96SY0-3;Q96SY0;H3BRY6 B4DVT3 VWA9 von Willebrand factor A domain-containing protein 9 0 4202390.0 729690.0 1782100.0 1690600.0 False True 999476.1121307958 1703360.9293833738 1291315.0989999338 1.0 1.7042537672580857 1.2919919579137942 19.93081256084416 -10.194739770610319 4.760844938140377 0.9999294703314361 1.4981228625040834 0.660620002151247 0.16830517890186825 118253883.77706806 13.436087120867176 94695.82070954953 0.05761533939134438 6.386460484758048e-11 10.194739770610319 0.49819339217264735 SESPK(ub)EPEQLRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SESPKEPEQLRK 12 2 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 23168000.0 5175000.0 6041000.0 11952000.0 True False 6699139.514500531 5704813.039534208 9776858.637876185 1.0 0.8515740009871317 1.4594200668181068 22.675544366702383 -6.8421525464003246 1.272356810567756 0.9210510094979885 1.480280874898569 0.928097790360956 0.06938331184329706 0.16629482768517698 0.5220157862211431 0.04274393853561355 0.09853817865063469 1.438293287466652e-07 6.8421525464003246 0.5592298654005805 SESPKEPEQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SESPKEPEQLR 11 1 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 38049100.0 2820200.0 23153900.0 12075000.0 False True 3697309.5108556473 19699428.37319531 10825594.831578882 1.0 5.328044167077693 2.927965538128177 21.818044389448186 -9.661099876137554 8.57904942453071 0.9996656623146318 4.128004852602938 0.6936989780132146 0.9798280162613264 0.0 0.0 0.9487143886905279 0.3162381295635092 2.1822279999455926e-10 9.661099876137554 3.1283391902883064 SESPKEPEQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SESPKEPEQLR 11 1 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 27241800.0 9932600.0 1221200.0 16088000.0 False True 9617295.049830351 1708831.5284738697 11874070.1703454 1.0 0.17768317594706773 1.2346579894681362 23.197199749500452 -6.6990428737535135 1.834283166804374 0.48891906159298987 1.2314664252179444 0.4131755094217735 0.3471670400437842 0.3974413307169783 2.599095331929974 0.151032068903407 0.38887414060115766 1.9996644520823331e-07 6.6990428737535135 0.7425473636249544 SESPKEPEQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SESPKEPEQLR 11 1 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 54596600.0 11612000.0 41272000.0 1712600.0 False True 17616252.95091244 33906689.140392184 1374103.859340753 1.0 1.9247390029464795 0.07800205089979596 24.070403753962545 -6.770573704253496 1.5723694294808583 1.5300234424588497 0.0674186934468428 0.7326983202422067 0.38978975252133274 0.26550966346059657 1.2955884538532234 0.19539545202176634 0.4648566764186002 1.6960017488432273e-07 6.770573704253496 -1.4626047490120069 SESPKEPEQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SESPKEPEQLR 11 1 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 37464900.0 2820200.0 14790100.0 19854600.0 False True 3862904.153039327 14136624.477679722 15165352.398322541 1.0 3.6595845813458894 3.9258940417640096 21.881254450971078 -10.107794265667195 0.5190411066791063 3.10709717590231e-22 3.913093282298631 0.9993930283758665 0.03254499502533441 1.4019538001452743 0.241163347252006 2.190619295640254 0.052123689517892195 7.801996197883924e-11 10.107794265667195 3.913093282298631 SESPKEPEQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SESPKEPEQLR 11 1 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 14050100.0 9932600.0 2950500.0 1167000.0 False True 8259396.988787803 2934605.070871604 1411014.304401652 1.0 0.3553050028779769 0.1708374480990701 22.97760502493473 -13.999999999998812 0.1754875202090332 4.300552371335853 0.017270504214892936 0.9995042810625326 0.007914239137261355 12.149667319228556 0.13274783304425505 13.660765493276195 0.14319965965303375 1.0000000000027364e-14 13.999999999998812 -4.2832818671209605 SESPKEPEQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SESPKEPEQLR 11 1 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 14534270.0 11612000.0 414870.0 2507400.0 False True 15031962.906740125 391782.11979996006 2051078.928096616 1.0 0.02606327079374912 0.1364478438924926 23.841530076054994 -10.208257440046639 4.214233908212106 1.0004221791705834 0.08125555729463735 0.9892894452791914 0.04506431345089603 134413674.84655154 267864571.8617235 758271.8123859044 0.0171377879000606 6.190739930841937e-11 10.208257440046639 -0.919166621875946 SESPKEPEQLRK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SESPKEPEQLRK 12 2 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 8444370.0 813070.0 3956900.0 3674400.0 False True 1065942.6437810797 3366545.9438753915 3294208.335333618 1.0 3.158280573083821 3.0904180018997094 20.02369838100588 -10.113920666214478 4.445950233936381 0.9997575503145627 3.124349287559649 0.9992352177573203 0.027704779037595474 9732081.447581233 13011328.827644795 30531.954404763615 0.01013891029881425 7.692709523249557e-11 10.113920666214478 2.1245917372450864 SESPKEPEQLRK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SESPKEPEQLRK 12 2 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 76228800.0 2780200.0 71055000.0 2393600.0 False True 4217766.659845576 58374680.09475113 1920503.9108478527 1.0 13.840187189702995 0.455336690180525 22.00804785222358 -6.655640095728505 1.988957250585219 9.29465544171076 0.5120501139954684 0.21710944407257304 5.472820567173446 0.49478843207569145 3.758167964852373 2.2269996665100344 6.0621682694428864 2.209835287480696e-07 6.655640095728505 -8.782605327715292 SESPKEPEQLRK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SESPKEPEQLRK 12 2 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 10238770.0 813070.0 6354400.0 3071300.0 False True 1113683.9513905698 6073641.596809228 2345922.1954090227 1.0 5.453649205616681 2.1064523669213817 20.08690844252877 -6.573344380903329 2.2923907432486317 4.044834914486501 2.1136770469868384 0.0 1.9380416092493444 0.7197432541637964 7.1041444280789205 0.712739111112437 2.171248993103548 2.6708876447350826e-07 6.573344380903329 -1.9311578674996621 SESPKEPEQLRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SESPKEPEQLRK 12 2 P09651;F8W6I7;P09651-3;F8VTQ5;F8W646;P09651-2 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 7683900.0 2780200.0 1981000.0 2922700.0 False True 3599023.7059351495 1870755.6085610483 2390798.589434467 1.0 0.5197953004521714 0.6642908701856565 21.77917417431603 -10.759531090813326 10.446824408628107 1.001254520691048 0.5920430853189201 0.9140019043347105 0.0589900693232972 0.0017273539159409757 3.9760866833929545e-05 0.05724040572558025 0.01903896300672926 1.7396781513378117e-11 10.759531090813326 -0.4092114353721278 SESQK(ub)EDPFNIAEPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SESQKEDPFNIAEPR 15 1 Q9Y2X9-2;Q9Y2X9 Q9Y2X9-2 ZNF281 Zinc finger protein 281 1 22776400.0 1598800.0 3401600.0 17776000.0 True False 1548046.969138873 4759876.619109663 13119932.33143087 1.0 3.0747624032088794 8.475151331312027 20.562017814137075 -6.954591807783275 0.5059321571921979 0.8971899272329218 10.888009241182067 0.9995140862166051 0.06945406624807147 0.0816926857532944 0.02872490614885643 0.08057093010709893 0.4455980757408575 1.1102178157711601e-07 6.954591807783275 9.990819313949144 SESQK(ub)EDPFNIAEPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SESQKEDPFNIAEPR 15 1 Q9Y2X9-2;Q9Y2X9 Q9Y2X9-2 ZNF281 Zinc finger protein 281 1 14389700.0 1598800.0 3233400.0 9557500.0 True False 1329473.0388492383 3215981.0324203516 11555929.061112922 1.0 2.418989282553659 8.692112380944161 20.34242308957135 -6.942583886178411 0.6350695820923292 0.9315040099732302 10.520635435941715 0.9984831417555067 0.13016917414581558 0.08660735639885815 0.04938815985703385 0.1293441467207084 0.5340725457565694 1.1413428271796297e-07 6.942583886178411 9.589131425968485 SETDTSLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SETDTSLIR 9 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 8449080.0 647780.0 4241700.0 3559600.0 False True 849245.8531104431 3608854.8940171036 3191286.7380942605 1.0 4.249481914806333 3.7577890152844096 19.695822742841134 -9.885052490615356 5.632140551329541 0.9999984221943227 4.003635465053762 0.9802978891718322 0.2007327856926724 3.977565864854798e-06 7.86760364641371e-07 0.19435878817105492 0.06478622799781975 1.3030092818795043e-10 9.885052490615356 3.003637042859439 SETDTSLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SETDTSLIR 9 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 8500900.0 2304800.0 1172800.0 5023300.0 False True 2231635.385583733 1641105.1560712059 3707547.034230231 1.0 0.7353822970690791 1.66135877669839 21.089669901876498 -6.83031451087228 1.3264261957049766 0.8586331875817733 1.6864498321995927 0.9065132498365389 0.11906834087159907 0.18042609392614617 0.6207129327432305 0.07047701977580612 0.162192686750904 1.4780376233189636e-07 6.83031451087228 0.8278166446178193 SETDTSLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SETDTSLIR 9 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 7568480.0 647780.0 3115300.0 3805400.0 False True 887281.7715962753 2977655.745080537 2906642.8946731044 1.0 3.355930258460679 3.275896099436228 19.759032804364026 -10.260879042248078 4.30085087583281 0.9984716154434491 3.315913178877112 0.9991050913996257 0.03267380894964922 2383756.156798881 2844154.464625342 28790.31713986445 0.011185113997222213 5.4842968983004175e-11 10.260879042248078 2.317441563433663 SETELK(ub)DTYAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SETELKDTYAR 11 1 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 10095550.0 1925150.0 2846900.0 5323500.0 True False 2523890.2931791204 2422153.617129281 4772675.286617823 1.0 0.9596905315873732 1.8909995016487455 21.267217770878293 -6.896781442358138 0.9813708330896735 0.9577866173624022 1.9826169271143335 0.9848964847980837 0.05282544579130225 0.11381409040928146 0.19107266215952792 0.04060250091304288 0.10403626306230411 1.2682899691250408e-07 6.896781442358138 1.0248303097519313 SETELK(ub)DTYAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SETELKDTYAR 11 1 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 14414990.0 2129090.0 2990100.0 9295800.0 True False 2061503.2033549421 4184062.523165507 6860951.111977655 1.0 2.0296172794474723 3.3281302210988426 20.9752652723453 -6.967978787743069 0.3025940969555603 0.7816255801709169 4.616960597383092 0.999962047606811 0.005868328961608594 0.07696413341392012 0.011365126832356688 0.021270382539634855 0.11614178526096203 1.076517792732948e-07 6.967978787743069 3.8353350172121754 SETELK(ub)DTYAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SETELKDTYAR 11 1 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 50883700.0 8064900.0 28910800.0 13908000.0 True False 12235042.923166873 23751441.85888857 11159077.703907035 1.0 1.9412634682233576 0.9120587295020834 23.54451582692278 -6.666129175346211 1.9513293622433718 1.6027929383578823 0.9162999264255078 0.2619687992584643 0.400188149055229 0.47003316947305784 3.4466830766408805 0.16533544523710503 0.4439387047341237 2.1571027110771442e-07 6.666129175346211 -0.6864930119323744 SETELK(ub)DTYAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SETELKDTYAR 11 1 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 8519360.0 1925150.0 839110.0 5755100.0 True False 2636929.980222561 802035.3456342982 4395863.910005042 1.0 0.3041549649212169 1.6670385421587965 21.330427832401185 -6.767900916049074 1.5824422487944625 0.5998232515647669 1.6741160651051272 0.7225214330979741 0.2931096985482906 0.2698173404046506 1.333098818993695 0.14602743855472977 0.34828617539734064 1.706471674789626e-07 6.767900916049074 1.0742928135403602 SETELK(ub)DTYAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SETELKDTYAR 11 1 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 16176090.0 2129090.0 5587400.0 8459600.0 True False 1770432.6696794617 5557299.567187941 10228463.24722896 1.0 3.1389499653743367 5.777380536635054 20.755670547779577 -6.968303623381539 0.295914337148586 0.5196114664606457 8.478914828301189 0.9999659613073032 0.011399619643390136 0.07685709743513133 0.010990006588940964 0.044684309522715064 0.2376744092117716 1.0757128997079924e-07 6.968303623381539 7.9593033618405435 SETELK(ub)DTYAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SETELKDTYAR 11 1 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 27691400.0 8064900.0 8101500.0 11525000.0 True False 10440172.032945955 7650644.403209146 9427568.25648619 1.0 0.732808269735985 0.9030088993491391 23.31564214901523 -10.732198796748229 5.506392267500951 1.0061047937634615 0.8179085845425682 0.6041396595455024 0.06948411607544337 0.005350223693571862 0.0002602057912018442 0.06912222278378526 0.022425902032177928 1.8526833700904183e-11 10.732198796748229 -0.1881962092208933 SETGGLSGK(ub)PLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SETGGLSGKPLR 12 1 I3NI32;Q02127 I3NI32 DHODH Dihydroorotate dehydrogenase (quinone), mitochondrial 1 8118700.0 2507500.0 2332700.0 3278500.0 True False 2427900.7850361033 3264159.274869796 2419762.4971082415 1.0 1.3444368464262666 0.996648014623159 21.211278037103533 -8.92583837363206 14.825768687258233 0.9999999975951085 1.170542430522027 0.24277218492552366 0.14198419602604395 0.0 0.0 0.13747560665837877 0.04582520221945958 1.1862101241706764e-09 8.92583837363206 0.17054243292691862 SETGGLSGK(ub)PLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SETGGLSGKPLR 12 1 I3NI32;Q02127 I3NI32 DHODH Dihydroorotate dehydrogenase (quinone), mitochondrial 1 21861900.0 4576600.0 5984300.0 11301000.0 True False 6943036.794277124 4916354.909450694 9067352.396595746 1.0 0.708098639705187 1.3059634660253585 22.727135386273392 -6.773903494284972 1.5592085191955503 0.8334163808587339 1.3098614123118402 0.7454150716610537 0.12316399354218534 0.2601396829190986 1.2485787032929214 0.06224010392290809 0.14765162662679887 1.683048014030546e-07 6.773903494284972 0.47644503145310624 SETGGLSGK(ub)PLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SETGGLSGKPLR 12 1 I3NI32;Q02127 I3NI32 DHODH Dihydroorotate dehydrogenase (quinone), mitochondrial 1 14509700.0 4576600.0 4666200.0 5266900.0 True False 5924498.918273075 4406521.868080537 4308378.242957668 1.0 0.7437796729930012 0.7272139471017934 22.498261708365842 -13.999999999999998 0.3893055750427214 5.033187180493866 0.7259896955195935 0.9998220850486396 0.0016655824964280819 25.2547562537731 0.20444285839399662 85.68745560168864 0.004368721042687037 1.0000000000000041e-14 13.999999999999998 -4.307197484974273 SETITADVNHNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SETITADVNHNLK 13 0 Q16222;Q16222-3 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 0 5002770.0 579450.0 2305820.0 2117500.0 False True 793688.3240474565 2203941.24807293 1617390.1112814164 1.0 2.7768346607819714 2.037815175399643 19.598213056581574 -10.53899728096056 5.99493624632884 0.997574996576549 2.407324918090799 0.8286266833364058 0.3017034415268197 0.009784476961615975 0.0007524131823393881 0.29229705141888074 0.0973743670439029 2.8906979804476322e-11 10.53899728096056 1.40974992151425 SETSGPQIK(ub)ELTDEEAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SETSGPQIKELTDEEAER 18 1 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 1 45939000.0 14332000.0 19733000.0 11874000.0 True False 21742691.809548497 16211491.9753673 9527098.695440914 1.0 0.7456064831976268 0.4381747567822768 24.37402722554662 -6.9685993588830915 0.2896958191742822 1.060289050109933 0.11399787697767018 0.999969301256891 0.0012726986045876031 0.07675987877133686 0.010648764485667902 0.0053797837297069 0.02788910707163091 1.0749806357335291e-07 6.9685993588830915 -0.9462911731322627 down SETSGPQIK(ub)ELTDEEAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SETSGPQIKELTDEEAER 18 1 Q9Y266;A0A0A0MSU9;A0A0A0MSS4 Q9Y266 NUDC Nuclear migration protein nudC 1 44884000.0 14332000.0 16252000.0 14300000.0 True False 18553056.525955867 15347561.913343837 11697546.730390668 1.0 0.8272255243696629 0.6304916235244425 24.14515354763907 -6.969432674381756 0.27139387518055463 1.0480876179765948 0.4037040681579973 0.9999776121391231 0.0007142411802829059 0.07648721464404393 0.009687001725533096 0.003823793385677027 0.018262486393826376 1.072919962177611e-07 6.969432674381756 -0.6443835498185975 SETSTSDNTETYQENTSSSGHPTFK(ub)CPLCQESNFTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SETSTSDNTETYQENTSSSGHPTFKCPLCQESNFTR 36 1 J3QLQ3;Q8WVD3-2;Q8WVD3 J3QLQ3 RNF138 E3 ubiquitin-protein ligase RNF138 1 54261000.0 13542000.0 22087000.0 18632000.0 True False 17753693.140914563 18791705.69445168 16704139.37076421 1.0 1.0584674155004372 0.9408825103701052 24.081615830905953 -6.771522260492749 1.5687876864097205 1.0334702878180173 0.9401852907005713 0.7362934272188939 0.024651231987454558 0.263974506358987 1.2823734404567166 0.012384655569504193 0.02943770234960777 1.6923015004589468e-07 6.771522260492749 -0.09328499711744598 SETSTSDNTETYQENTSSSGHPTFK(ub)CPLCQESNFTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SETSTSDNTETYQENTSSSGHPTFKCPLCQESNFTR 36 1 J3QLQ3;Q8WVD3-2;Q8WVD3 J3QLQ3 RNF138 E3 ubiquitin-protein ligase RNF138 1 51561000.0 13542000.0 19685000.0 18334000.0 True False 18548843.358789675 18815251.61041004 14003886.800582504 1.0 1.0143625263563467 0.7549735867463958 24.144825892428845 -6.893797526632015 0.999623899725229 1.012695116742404 0.73092841499783 0.9832204671467912 0.015419470482920717 0.11611691026229297 0.20427118843941058 0.011690460307325788 0.029573225829287068 1.2770340388449996e-07 6.893797526632015 -0.2817667017445741 SEVATLTAAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEVATLTAAGK 11 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 12436600.0 2282700.0 5524000.0 4629900.0 False True 2992641.805698244 4699840.732383349 4150842.361136822 1.0 1.5704655075774365 1.3870160983627462 21.512988179911666 -10.154046753211452 4.554231193157727 0.9999327915280177 1.478740802978967 0.9007980002415215 0.07489290772877623 52410902.56131607 4.762820877775681 36939.125553058584 0.02563783434560808 7.01379788543468e-11 10.154046753211452 0.4788080114509493 SEVATLTAAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEVATLTAAGK 11 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 9536600.0 3111200.0 1235900.0 5189500.0 False True 3012436.65898478 1729401.3151333572 3830214.2683371087 1.0 0.5740871961491074 1.271467154973452 21.522499476150838 -6.741439881673777 1.681569076753054 0.7470018366315644 1.2719928188061194 0.6113023170928376 0.17894569098470464 0.3152303141743723 1.7507767076272525 0.08416923118603331 0.20620663548839463 1.8136777214794185e-07 6.741439881673777 0.524990982174555 SEVATLTAAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEVATLTAAGK 11 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 9908000.0 2282700.0 3418800.0 4206500.0 False True 3126675.877647994 3267746.111540251 3213011.3355869027 1.0 1.0451182787767486 1.027612538464925 21.576198241434557 -10.137413277092534 4.253208651945753 0.9999922030067446 1.0363654086244254 0.8519351110081298 0.007146688567652214 5.285018597380213e-07 1.0717762411506916e-07 0.006921235010303904 0.002306583815248843 7.28763684526537e-11 10.137413277092534 0.03637320561768076 SEVAVLSPEK(ub)AENDDTYKDDVNHNQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEVAVLSPEKAENDDTYKDDVNHNQK 26 2 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 35466100.0 8448100.0 13258000.0 13760000.0 True False 11075540.911516769 11279958.079279242 12336247.1952402 1.0 1.0184566306418419 1.1138279650443528 23.40087382360641 -6.939073242723419 0.6681259375241805 0.9989104504301803 1.1388605618488172 0.9980400195822107 0.0022083132035075506 0.08819186694183624 0.05655333435910003 0.002134830383438589 0.00824249648461634 1.1506063255817977e-07 6.939073242723419 0.1399501114186369 SEVAVLSPEK(ub)AENDDTYKDDVNHNQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEVAVLSPEKAENDDTYKDDVNHNQK 26 2 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 32311300.0 8448100.0 8180200.0 15683000.0 True False 11571590.87131818 7818771.715696029 11978998.401523693 1.0 0.6756868439823567 1.035207564347555 23.464083885129302 -6.669087501800628 1.9407155312517723 0.7928272009861249 1.033744691259876 0.274944205195249 0.1377907486730489 0.4632287786619824 3.362761539950997 0.05717818496996043 0.15294177140202445 2.142458894281123e-07 6.669087501800628 0.2409174902737511 SEVAVLSPEK(ub)AENDDTYKDDVNHNQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEVAVLSPEKAENDDTYKDDVNHNQK 26 2 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 32936500.0 6868600.0 16308000.0 9759900.0 True False 5711545.230572854 16220145.567115458 11800649.965321057 1.0 2.839887440668769 2.0661046159897922 22.44544968179402 -10.586452928030548 6.113177361455246 0.9956929706732895 2.452996028329281 0.8246052212804789 0.3158955153654915 0.0185299875400367 0.001253522999080429 0.30564277288060626 0.10195483917934652 2.5914752889228782e-11 10.586452928030548 1.4573030576559913 SEVAVLSPEKAENDDTYKDDVNHNQK(ub)CK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEVAVLSPEKAENDDTYKDDVNHNQKCK 28 3 Q13233 Q13233 MAP3K1 Mitogen-activated protein kinase kinase kinase 1 1 76284300.0 49956000.0 18318000.0 8010300.0 True False 64669026.779978536 17298587.19718388 6552507.592618772 1.0 0.2674941631028149 0.10132373902752811 25.94657156328971 -13.999999999997456 0.2084366480934487 5.20935822252089 0.001953192893889539 0.9994891936620944 0.008823718115436334 12.7105411468313 0.14471742292009795 21.89490941329585 0.09952039420518505 1.0000000000058571e-14 13.999999999997456 -5.207405029627 SEVELLEMEK(ub)SQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEVELLEMEKSQIR 14 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 8548000.0 2507500.0 2844000.0 3196500.0 True False 3287356.7826645384 2419686.2858251706 2865756.842993122 1.0 0.7360583124366303 0.871751085280834 21.6484966124925 -10.178525367581042 5.033497254982987 1.00001437397189 0.8039046988584826 0.7357698748377861 0.05539634254281405 8.936350202524942e-06 1.4585204510178746e-06 0.053641207495558514 0.01787909267563589 6.629406235057113e-11 10.178525367581042 -0.1961096751134075 SEVELLEMEK(ub)SQIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEVELLEMEKSQIR 14 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 15407900.0 6088900.0 5651800.0 3667200.0 True False 5895611.202395357 7908593.213747639 2706650.306358195 1.0 1.341437374726206 0.4590957940473579 22.491209955549714 -6.801813546453689 1.4488074953775922 1.1879544208387258 0.446406157105076 0.8373261837527545 0.14651697214654127 0.21818178206909286 0.9040019557220261 0.07955649898116651 0.1847926627797719 1.578288723317784e-07 6.801813546453689 -0.7415482637336499 down SEVELLEMEK(ub)SQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEVELLEMEKSQIR 14 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 32398400.0 8507100.0 17321000.0 6570300.0 True False 12905892.65231719 14229932.22040931 5271677.325135212 1.0 1.1025918627840434 0.4084705697740875 23.621526594913718 -6.869309662411916 1.137670854398955 1.057793058821315 0.3683369650866416 0.9639929994121225 0.05804826614039696 0.1375222268419688 0.3330907370333291 0.03961317333448393 0.09367998309783507 1.351108846551994e-07 6.869309662411916 -0.6894560937346733 down SEVELLEMEK(ub)SQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEVELLEMEKSQIR 14 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 9693800.0 2507500.0 3382800.0 3803500.0 True False 3434590.512639567 3233336.710576334 2905191.635541378 1.0 0.9414038438286594 0.845862592600207 21.711706674015392 -6.9638356404006965 0.37753310246625355 1.0067475450555352 0.7771536680334028 0.9998870418588587 0.000675140933823626 0.0783586960331396 0.016269190439044234 0.0012467183153132277 0.008082809764750917 1.0868368613391983e-07 6.9638356404006965 -0.2295938770221324 SEVELLEMEK(ub)SQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEVELLEMEKSQIR 14 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 12734900.0 6088900.0 4114700.0 2531300.0 True False 5063190.134006216 4092533.2943959967 3060583.1265911716 1.0 0.808291449872495 0.6044772259361125 22.27161523098399 -6.970348537266533 0.2497231736919451 1.0649017510538505 0.34189959651108404 0.9999849731402889 0.0006260071765313038 0.07618976716330138 0.008624632269056487 0.004554352854704192 0.01954249487108018 1.0706597166269477e-07 6.970348537266533 -0.7230021545427665 SEVELLEMEK(ub)SQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEVELLEMEKSQIR 14 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 28342300.0 8507100.0 13103000.0 6732200.0 True False 11012608.650011104 12373806.531537311 5507008.678205328 1.0 1.1236035824740613 0.500063958796881 23.392652917006167 -6.8551975353423 1.2097179895742654 1.0663811172406457 0.4725178662899296 0.9475378414626756 0.061744156136480856 0.1518295227065007 0.42496167894818293 0.039878670777513454 0.09264415250703341 1.395733378588568e-07 6.8551975353423 -0.593863250950716 SEVIK(ub)NNLNPTWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEVIKNNLNPTWK 13 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX45;Q5JX52;Q5JX61 Q99829 CPNE1 Copine-1 1 10720700.0 1981300.0 2922100.0 5817300.0 True False 1918404.7160087905 4088909.768550189 4293574.614740813 1.0 2.131411445368576 2.238096361477637 20.871475679766373 -10.789765685182067 0.44330605502667214 1.1057078344361175e-23 2.2403662986129365 0.9995744426126721 0.011556264851388116 2.4026152390262254 0.21354577803679803 2.575220338827672 0.024391433428954834 1.622685348338255e-11 10.789765685182067 2.2403662986129365 SEVIK(ub)NNLNPTWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEVIKNNLNPTWK 13 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX45;Q5JX52;Q5JX61 Q99829 CPNE1 Copine-1 1 8556400.0 1981300.0 2789500.0 3785600.0 True False 1647538.7364723545 2774472.4098276054 4577151.457363235 1.0 1.6840104262241489 2.778175320577683 20.65188095520065 -6.9641664250941515 0.37208069731615045 0.9178178730678606 3.5825789849564913 0.9998949184265576 0.007507224525634141 0.07824497250396484 0.015864290478654765 0.01437792290771557 0.092824131916089 1.086009376450609e-07 6.9641664250941515 2.6647611118886307 SEVIK(ub)NNLNPTWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SEVIKNNLNPTWK 13 1 Q99829;F2Z2V0;A6PVH9;E7ENH5;Q5JX44;B0QZ18;Q5JX58;Q5JX59;Q5JX60;Q5JX45;Q5JX52;Q5JX61 Q99829 CPNE1 Copine-1 1 12024100.0 3856900.0 4083400.0 4083800.0 True False 4992833.080865141 3856155.2004029187 3340590.303326539 1.0 0.7723380970178032 0.669077104966564 22.251427244982075 -13.999999999999845 0.10654449969930747 2.105877779454603 0.46986485526442656 0.9997606284891557 0.0021388536674879694 12.034054941305627 0.0984666160639311 2.8823225285544103 0.17712821690768268 1.0000000000003558e-14 13.999999999999845 -1.6360129241901764 SEVSSDEDIQFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEVSSDEDIQFR 12 0 H0YFD6;P40939;A0A2R8Y4F5 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 7832300.0 1204600.0 2978700.0 3649000.0 False True 1579242.2653629926 2534289.5708816624 3271436.4836796136 1.0 1.604750345444402 2.0715228786811033 20.59080107568859 -6.97401361806628 0.13053400991671052 0.28266408509814495 3.405694840815119 0.9999992064920492 0.00039070676835506127 0.07502045731065227 0.003920549890290735 0.029196317486002155 0.06359900817967794 1.0616622663917023e-07 6.97401361806628 3.123030755716974 SEVSSDEDIQFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEVSSDEDIQFR 12 0 H0YFD6;P40939;A0A2R8Y4F5 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 6126800.0 2753000.0 0.0 3373800.0 False True 2665607.5219160137 0.0 2490100.568169522 1.0 0.0 0.9341587415613463 21.346032946199553 -10.041235822468689 13.085212808833216 0.9999902922513961 0.46707937078027517 0.3026172287604201 0.3813687093054784 0.0 0.0 0.3692586649575744 0.12308622165252478 9.094193226612935e-11 10.041235822468689 -0.532910921471121 SEVSSDEDIQFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SEVSSDEDIQFR 12 0 H0YFD6;P40939;A0A2R8Y4F5 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 8000000.0 1204600.0 2639300.0 4156100.0 False True 1649973.1730909764 2522686.999002044 3174514.777566327 1.0 1.5289260699167426 1.923979631510827 20.65401113721148 -6.9743369917294284 0.11414709639198041 0.22212754553580133 3.240888148248841 0.9999995536975053 0.00025281473728950904 0.07491891123237032 0.003384058242488779 0.02982281075614669 0.05893512447827791 1.0608720518085987e-07 6.9743369917294284 3.01876060271304 SEVSSDEDIQFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEVSSDEDIQFR 12 0 H0YFD6;P40939;A0A2R8Y4F5 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 3798400.0 2753000.0 1045400.0 0.0 False True 2289241.478578908 1039768.2227043464 0.0 1.0 0.4541977036646231 0.0 21.12643822163383 -8.078749614902778 0.5660176842347325 1.0188330109823298 7.32378265861626e-18 0.9902205174017418 0.04042861387996331 0.1145140972769403 0.1680929493741871 0.048525753668103785 0.07508366569380377 8.341619679080838e-09 8.078749614902778 -1.0188330109823298 SEWSDLLSDLQK(ub)AGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEWSDLLSDLQKAGK 15 1 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0;F8VZQ1 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 1 8277100.0 1777000.0 2833200.0 3666900.0 True False 1477654.234447772 2817936.9892538292 4433631.836170025 1.0 1.9070340838612674 3.0004528345069574 20.494877293066946 -6.968634758378936 0.28893878836013204 0.7836234104826663 4.15759577952606 0.99996968949254 0.004502734848119517 0.07674822907086519 0.010607739378577936 0.01921226781252958 0.09927851221373737 1.0748930172550831e-07 6.968634758378936 3.3739723690433943 SEYSELDEDESQAPYDPNGK(ub)PER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SEYSELDEDESQAPYDPNGKPER 23 1 P19387 P19387 POLR2C DNA-directed RNA polymerase II subunit RPB3 1 10426500.0 2401500.0 2674300.0 5350700.0 True False 2325265.6970146387 3742161.936290265 3949191.152440764 1.0 1.6093481020662501 1.6983827514898835 21.148964144841404 -11.438422552016544 0.3315560504487496 1.511706596782086e-12 1.716165189848159 0.9994447192055695 0.00731370026943545 3.7589357484078025 0.17206940509973345 2.7358077602424715 0.028316251361389627 3.643992277973651e-12 11.438422552016544 1.7161651898466472 SEYSELDEDESQAPYDPNGK(ub)PER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SEYSELDEDESQAPYDPNGKPER 23 1 P19387 P19387 POLR2C DNA-directed RNA polymerase II subunit RPB3 1 42707600.0 4485600.0 12431000.0 25791000.0 True False 6804983.141285982 10212590.926153697 20693397.545403145 1.0 1.5007518334900323 3.0409182676523985 22.698160156914835 -6.95088941537763 0.5489971114776284 0.9785722203811843 3.635327698910994 0.9992692148528133 0.02347747031588813 0.08313064854318734 0.03450008849223882 0.02551484139886854 0.12774573145211052 1.1197229627918829e-07 6.95088941537763 2.65675547852981 SEYSELDEDESQAPYDPNGK(ub)PER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SEYSELDEDESQAPYDPNGKPER 23 1 P19387 P19387 POLR2C DNA-directed RNA polymerase II subunit RPB3 1 11386300.0 2401500.0 2523200.0 6461600.0 True False 1996953.654488646 2509607.0207840153 7812690.6849371875 1.0 1.2567177085672743 3.9123044580309805 20.92936942027568 -6.925649515079314 0.7816796268358293 0.952448785656472 4.401623745396546 0.9956119046117651 0.08721134402927798 0.09496045039746812 0.08921457190818811 0.07748591996173912 0.2462819625755474 1.1867260751071534e-07 6.925649515079314 3.4491749597400743 up SEYSVHSSLASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SEYSVHSSLASK 12 0 O43683-2;O43683-3;O43683;A0A590UK50 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 0 1586940.0 359430.0 324310.0 903200.0 False True 471216.2107250714 275924.2121504786 809745.5281061744 1.0 0.5855575548343458 1.718416110643138 18.846029645885288 -6.807688799161535 1.4241267309362031 0.7735031686955585 1.737222686615305 0.8537252981332254 0.1789923675935591 0.20997314281740972 0.8397296283841937 0.09883722201058569 0.22889006476394416 1.557080983878514e-07 6.807688799161535 0.9637195179197466 SFAGNLNTYK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFAGNLNTYKR 11 1 Q01813;Q01813-2;B1APP6 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 1 6851300.0 1462700.0 1895000.0 3493600.0 True False 1416267.3891415005 2651683.382294454 2578521.3542465605 1.0 1.872304200905047 1.8206458568601118 20.433662239102848 -10.101124711304248 4.976364916642814 0.9999715238303308 1.8464750288860703 0.9972145039827167 0.021089430656633393 6.663093226740644e-06 1.2035296104062754e-06 0.020420437958189805 0.006806584474448979 7.922737897459466e-11 10.101124711304248 0.8465035050557395 SFAGNLNTYK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFAGNLNTYKR 11 1 Q01813;Q01813-2;B1APP6 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 1 6528600.0 1462700.0 3580200.0 1485700.0 True False 1216299.8585969366 3560912.751985941 1796353.0008993424 1.0 2.9276602531991034 1.4768997860211268 20.214067514537124 -6.573707537201595 2.2910920487247495 2.3175772939386152 1.4800529241612388 0.0 0.8387523808625448 0.7184812979284647 7.08424436319953 0.3085770478790542 0.9395140454440423 2.668655186602556e-07 6.573707537201595 -0.8375243697773764 SFANTLVDVCAYAGSGNVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFANTLVDVCAYAGSGNVLK 20 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 50329700.0 5916700.0 31083000.0 13330000.0 False True 8976066.468710262 25535995.797412544 10695319.657253454 1.0 2.8448982509686913 1.191537484101343 23.097651928617985 -6.6199176536086695 2.117036456508482 2.224250665902173 1.1978770225999849 0.08238348336662815 0.7933968792446943 0.5857638686453175 4.988529380160742 0.30794943826466104 0.8797353546321447 2.399287803829193e-07 6.6199176536086695 -1.0263736433021882 SFANTLVDVCAYAGSGNVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFANTLVDVCAYAGSGNVLK 20 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 24587700.0 5916700.0 18671000.0 0.0 False True 7659284.785593288 17631942.43687193 0.0 1.0 2.302035102551179 0.0 22.868778250710434 -6.755880373434811 1.6452472277727845 1.762476669508428 3.7096456451189783e-10 0.6627571168292172 0.5473311543517934 0.29232928001944564 1.5614503495550676 0.2634008167127649 0.6312892353162614 1.7543636753744647e-07 6.755880373434811 -1.7624766691374634 SFAVGMFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFAVGMFK 8 0 P49748-2;P49748;P49748-3;K7EQP4;K7EJW8 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 21347900.0 5896700.0 5523500.0 9927700.0 False True 7730630.8037240235 4699415.3304343615 8900476.837222837 1.0 0.6078954550734132 1.1513260771598706 22.882154709253598 -6.713140941390878 1.7842356033145956 0.7597141496165405 1.150157468317403 0.479877434650272 0.16515255319090616 0.36881044315617145 2.2906521596318234 0.07361070572332014 0.18628112287868404 1.9357936397669096e-07 6.713140941390878 0.39044331870086246 SFAVGMFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFAVGMFK 8 0 P49748-2;P49748;P49748-3;K7EQP4;K7EJW8 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 15799100.0 5230000.0 2151700.0 8417400.0 False True 5063976.512757261 3010885.030967264 6212630.423412806 1.0 0.594569311959127 1.2268284435683767 22.271839282738295 -6.733517678320667 1.7102467055545223 0.7569722756084967 1.2267101049584617 0.575517535180895 0.17039221262377294 0.32970653881276085 1.8908037717314172 0.07889973060211085 0.19502125106515666 1.8470656070266167e-07 6.733517678320667 0.469737829349965 SFAVGMFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFAVGMFK 8 0 P49748-2;P49748;P49748-3;K7EQP4;K7EJW8 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 13784800.0 4535900.0 4760600.0 4488300.0 False True 6881291.918708567 3911033.735262432 3601185.537708225 1.0 0.5683574801745117 0.523329860184753 22.714248016481292 -13.999999999999998 0.3193503029106228 5.4087653498612775 0.5143255537829952 0.9996923317850066 0.0037690764259887314 17.962979734022053 0.1801895337466216 52.893552648201094 0.015029480117916934 1.0000000000000041e-14 13.999999999999998 -4.894439796078283 SFAVGMFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFAVGMFK 8 0 P49748-2;P49748;P49748-3;K7EQP4;K7EJW8 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 17846400.0 5896700.0 5306100.0 6643600.0 False True 8076869.342325719 5071658.957073752 5074518.509236941 1.0 0.627923857885929 0.628277900032953 22.94536477077649 -10.329243851477534 8.07399505864462 1.0000014280374325 0.6281008797491857 0.9999993192102676 0.00014453710127616606 3.715425106101111e-09 3.086511082144886e-10 0.00013994798238445535 4.6649148846617886e-05 4.685502225801337e-11 10.329243851477534 -0.3719005482882468 SFAVGMFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFAVGMFK 8 0 P49748-2;P49748;P49748-3;K7EQP4;K7EJW8 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 13234800.0 5230000.0 4292100.0 3712700.0 False True 4348976.7282846635 4268977.605384855 4489008.404414743 1.0 0.9816050699054069 1.032198764187297 22.05224455817257 -6.808328554086361 1.4215589069886836 0.989954998631485 1.0330503707982415 0.8554189790794774 0.00795057795032918 0.20908666879738017 0.8330793844398383 0.004398113527993503 0.010181611026839536 1.554788951813031e-07 6.808328554086361 0.04309537216675652 SFAVGMFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFAVGMFK 8 0 P49748-2;P49748;P49748-3;K7EQP4;K7EJW8 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 15320100.0 4535900.0 6544800.0 4239400.0 False True 5871811.965956137 6180576.12665842 3467872.699917356 1.0 1.0525841362925874 0.5905966880451127 22.48537433857374 -6.878591573446439 1.0875736074988682 1.032025259449186 0.5587210141409021 0.9725337354929925 0.034224402097157776 0.12888736450593133 0.27985904234233655 0.02427002951569878 0.05848924990475349 1.3225388138229713e-07 6.878591573446439 -0.47330424530828397 SFCSIFSVLPYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFCSIFSVLPYR 12 0 Q8TDN4-2;Q8TDN4;Q8TDN4-4;V9GYB4;J3QRY5 Q8TDN4-2 CABLES1 CDK5 and ABL1 enzyme substrate 1 0 3214680.0 740480.0 1225700.0 1248500.0 False True 970776.4508185209 1042830.337741178 1119317.1964576596 1.0 1.0742229448004266 1.1530123083578048 19.888779586325725 -6.970368783811627 0.24923260587238472 0.9747587104300266 1.2547818906370343 0.9999851059431332 0.00024104446453300678 0.0761833350680999 0.008601484247325326 0.0017664733955157737 0.0075607134048549 1.0706098042843878e-07 6.970368783811627 0.28002318020700767 SFCSIFSVLPYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFCSIFSVLPYR 12 0 Q8TDN4-2;Q8TDN4;Q8TDN4-4;V9GYB4;J3QRY5 Q8TDN4-2 CABLES1 CDK5 and ABL1 enzyme substrate 1 0 6020380.0 740480.0 2246800.0 3033100.0 False True 1014255.4667195814 2147528.9468259714 2316744.2486553313 1.0 2.117345202754243 2.2841821658091774 19.951989647848617 -10.691687290426307 0.37363710655862864 1.0396303206599088e-24 2.3059780816008013 0.9993072523335605 0.015005838435838735 2.2777415024127605 0.1805479321038194 2.1233404859286282 0.045923080717124656 2.0338209170695878e-11 10.691687290426307 2.3059780816008013 SFDFEIETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFDFEIETK 9 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 8943900.0 2243600.0 2907200.0 3793100.0 False True 2941381.3270533048 2473457.0921768416 3400626.3979844246 1.0 0.8409168404746648 1.1561324493044207 21.48806239978738 -6.769485268412247 1.5762921611948746 0.9086945512318905 1.1578765270309381 0.7286354080706148 0.06703706945326973 0.2672627072435333 1.3104601799329574 0.03352255458547181 0.07983961474635705 1.700257626651489e-07 6.769485268412247 0.24918197579904766 SFDFEIETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFDFEIETK 9 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 13259700.0 4726900.0 2435100.0 6097700.0 False True 4576847.146874244 3407448.1288787453 4500529.442921126 1.0 0.7444968161556063 0.9833252670443148 22.125922680330078 -10.503741905745644 8.121977704437162 1.0000126831086702 0.8639110416638892 0.30212663576881826 0.09750130678944792 2.2394428146653296e-05 1.3683822123222193e-06 0.09441402617211453 0.03146841145241598 3.1351483392409594e-11 10.503741905745644 -0.13610164144478099 SFDFEIETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFDFEIETK 9 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 9109600.0 2243600.0 3499300.0 3366700.0 False True 3073119.5510102236 3344689.355362352 2571554.799362994 1.0 1.0883694239174182 0.8367897039728406 21.551272461310273 -6.811772363161632 1.4069228918917223 1.0480603805103244 0.8322011821775939 0.864448424555115 0.03836765168151324 0.20438711958602993 0.7970083888773474 0.021440332604059666 0.04956069782118874 1.5425087519787404e-07 6.811772363161632 -0.21585919833273048 SFDFHFGFCIPSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFDFHFGFCIPSSK 14 0 K7EJU3;K7EN86;C9JSK0;Q13432-2;Q13432 K7EJU3 UNC119 Protein unc-119 homolog A 0 14463300.0 4981000.0 4109300.0 5373000.0 False True 7556541.159877266 3375963.3088925574 4311024.194930443 1.0 0.4467603944007883 0.5705023110071252 22.84929459300847 -9.880784966154675 6.73543865916243 1.0000000142233942 0.5086313527041272 0.9545954454081426 0.05051742591330206 1.0769818811991038e-08 1.7314146524859281e-09 0.048913288771579494 0.016304429104617452 1.3158762056100628e-10 9.880784966154675 -0.49136866151926706 SFDFHFGFCIPSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFDFHFGFCIPSSK 14 0 K7EJU3;K7EN86;C9JSK0;Q13432-2;Q13432 K7EJU3 UNC119 Protein unc-119 homolog A 0 10065000.0 4981000.0 1975000.0 3109000.0 False True 6448002.690188816 1865089.5138354723 2543193.9010338914 1.0 0.2892507344442279 0.3944157630243513 22.62042091510092 -10.07067499123238 5.4595259935975635 1.0000050685672295 0.34183324874716575 0.9812113895554901 0.04293344313666767 2.9028098982921646e-06 4.941309012967588e-07 0.04157047796252895 0.013856709188306985 8.498162058764377e-11 10.07067499123238 -0.6581718198200637 SFDHSGK(ub)DTER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFDHSGKDTER 11 1 Q9NVE7;E9PHT6 Q9NVE7 PANK4 Pantothenate kinase 4 1 6218600.0 0.0 2785700.0 3432900.0 True False 0.0 2370084.418573554 3077696.438702045 0.0 SFDK(ub)GPFATFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFDKGPFATFK 11 1 Q6UXN9;C9JBU3 Q6UXN9 WDR82 WD repeat-containing protein 82 1 3001070.0 1132000.0 1363400.0 505670.0 True False 941308.1561029139 1356055.0935862884 611403.2590460861 1.0 1.4406069731728002 0.6495250838761891 19.84430756987015 -6.755535487267815 1.6292462953909903 1.2573433335571826 0.6472523181088241 0.6724994149901193 0.1852206662920339 0.2904789117738182 1.5185818275411134 0.08974438805797753 0.216633846564844 1.7557574210901923e-07 6.755535487267815 -0.6100910154483585 SFDK(ub)NLYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFDKNLYR 8 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;A0A3B3ITP6;A0A3B3ISC1 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 16495060.0 2726900.0 3073760.0 10694400.0 True False 2640336.052129592 4301128.397446647 7893215.814877024 1.0 1.6290079416131615 2.989473937800707 21.332290131440647 -6.958485073225031 0.45628220451115586 0.9588379422445876 3.7141464271826643 0.9997098228594014 0.014143750487667172 0.08024677647953457 0.02316479587760889 0.018362816528968977 0.11243684550662911 1.100309662475475e-07 6.958485073225031 2.7553084849380767 SFDK(ub)NLYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFDKNLYR 8 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;A0A3B3ITP6;A0A3B3ISC1 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 26737100.0 3828700.0 3373900.0 19534500.0 True False 5808417.815463178 2771801.1845989814 15673497.512724511 1.0 0.4772041668937604 2.698410825577751 22.46971380341135 -6.8446660703968165 1.2605709554577176 0.7218209747140586 2.7784705322366334 0.9321775229338571 0.24693619573987205 0.16342099375751748 0.5024108286691475 0.15347494736226122 0.354142428092018 1.429993059467028e-07 6.8446660703968165 2.056649557522575 up SFDK(ub)NLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFDKNLYR 8 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;A0A3B3ITP6;A0A3B3ISC1 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 6182500.0 1786600.0 2365800.0 2030100.0 True False 2447154.301049591 2261271.133345596 1550632.1912219124 1.0 0.9240410922906377 0.6336470857423425 21.222673640230965 -6.945915742242629 0.6020242148238049 1.0032568703327551 0.5395143696535994 0.9988404614676685 0.005375863160487083 0.08516861093935665 0.04307909062104702 0.005506517590600363 0.024420156669724746 1.132620082286215e-07 6.945915742242629 -0.4637425006791557 SFDK(ub)NLYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFDKNLYR 8 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;A0A3B3ITP6;A0A3B3ISC1 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 21529200.0 3828700.0 4948800.0 12751700.0 True False 4956327.624960032 4673394.929655176 10431021.443491098 1.0 0.942914852141733 2.1045867490600387 22.240840125503798 -6.895346517294062 0.9902315954412225 0.9453441697682241 2.215622478627618 0.9841050577228034 0.06740865164899675 0.1149117137403532 0.19737188719327906 0.05146985674348825 0.13104585055115522 1.2724873765649286e-07 6.895346517294062 1.270278308859394 up SFDLLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFDLLVK 7 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 53647000.0 13848000.0 19989000.0 19810000.0 False True 18154862.10422278 17006719.116511736 17760251.230938125 1.0 0.9367583746370628 0.9782641767797913 24.1138526363596 -10.116422660316301 4.876649989551399 1.000002086297541 0.9575112757081872 0.5828521799042394 0.016944672769928504 3.8438018657831714e-07 6.96154910184433e-08 0.01640741456732234 0.005468869620287594 7.648518820548194e-11 10.116422660316301 -0.04249081058935378 SFDLLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFDLLVK 7 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 48676700.0 18529000.0 8575700.0 21572000.0 False True 17940807.03726182 12000021.731684718 15921646.053871853 1.0 0.6688674431847742 0.8874542834557938 24.096741453156994 -10.403091632089525 4.984044769008413 1.0002349741773437 0.7781608633202565 0.5786466786958655 0.08923770385863679 0.00023324308309259455 2.793406581795452e-05 0.08649492282449797 0.0288013450748438 3.9528321019443615e-11 10.403091632089525 -0.22207411085708728 SFDLLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFDLLVK 7 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 149986000.0 30081000.0 86117000.0 33788000.0 False True 45635076.21567322 70748748.51480787 27109786.990193486 1.0 1.550315116829134 0.5940559157186794 25.44363980503986 -6.750644802935189 1.647480719427596 1.3233368699406842 0.5920628727667744 0.6517521923623811 0.23125322689874675 0.2989116907570322 1.5964403113806478 0.11087621607189542 0.268993126298273 1.775641133394429e-07 6.750644802935189 -0.7312739971739098 SFDLLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFDLLVK 7 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 60945000.0 13848000.0 20573000.0 26524000.0 False True 18967979.82812874 19664016.83418671 20259577.478927143 1.0 1.0366953683188642 1.0680935799437647 24.17706269788249 -6.97293871598644 0.17424701662305 0.9737957085116246 1.1318375051886789 0.9999971208877719 4.686258634890423e-05 0.07536027989989869 0.005460209453685875 0.0012729511692067827 0.003587479728047139 1.0642931918032766e-07 6.97293871598644 0.1580417966770543 SFDLLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFDLLVK 7 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 37851600.0 18529000.0 8881600.0 10441000.0 False True 15407684.473878883 8833753.057940437 12624164.826270478 1.0 0.5733342393476818 0.819342117738237 23.87714672859127 -10.205822544070532 5.518047940599506 1.0000125915999611 0.6963381785429358 0.670132468292451 0.1004322957936695 1.5558180216763068e-05 2.239107840010602e-06 0.09724718250950808 0.03241438408584283 6.225546136136224e-11 10.205822544070532 -0.30367441305702536 SFDLLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFDLLVK 7 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 97124000.0 30081000.0 38467000.0 28576000.0 False True 38940447.4851576 36326277.634789355 23375461.214520562 1.0 0.9328674933341572 0.6002874318131621 25.21476612713231 -6.94001184465951 0.6594588018611142 1.003732379717819 0.5105715776129753 0.9981653721309154 0.007485645265647237 0.08776140733481233 0.05458625159744541 0.00728732837025648 0.02862304592743723 1.1481223079439182e-07 6.94001184465951 -0.4931608021048437 SFDLLVK(ub)NLNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFDLLVKNLNGK 12 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 4741600.0 0.0 0.0 4741600.0 True False 0.0 0.0 3878677.45292451 0.0 SFDSNAFTLLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFDSNAFTLLLR 12 0 Q9UBI1;R4GMW6;H0Y6Z9;R4GMX3;H0Y4W0;R4GN54;R4GN06;Q5T8Z1 Q9UBI1 COMMD3;COMMD3-BMI1 COMM domain-containing protein 3 0 6957300.0 1808400.0 2514400.0 2634500.0 False True 2370829.9125705087 2139261.321054437 2361907.2119084545 1.0 0.902325936462899 0.9962364652922824 21.176960734424576 -10.531557407627457 5.942017130899028 1.0000834971172534 0.9492812008813937 0.28001046497820115 0.03833881285115307 4.2477903177516486e-05 3.348794544573004e-06 0.037182465102029764 0.012373798640489896 2.940644956116128e-11 10.531557407627457 -0.050802296235859745 SFDSNAFTLLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFDSNAFTLLLR 12 0 Q9UBI1;R4GMW6;H0Y6Z9;R4GMX3;H0Y4W0;R4GN54;R4GN06;Q5T8Z1 Q9UBI1 COMMD3;COMMD3-BMI1 COMM domain-containing protein 3 0 10586400.0 4152700.0 3635600.0 2798100.0 False True 4020874.811573053 5087314.039403544 2065193.6687993195 1.0 1.2652256729707227 0.513617997470399 21.939077988393485 -6.811326998878592 1.4088675989446282 1.1443213909816305 0.5000559806262136 0.8632814094027039 0.11508202394872388 0.20499772589709114 0.8017011181758711 0.06422275762290956 0.14847870790644463 1.5440913893317097e-07 6.811326998878592 -0.644265410355417 SFDSNAFTLLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFDSNAFTLLLR 12 0 Q9UBI1;R4GMW6;H0Y6Z9;R4GMX3;H0Y4W0;R4GN54;R4GN06;Q5T8Z1 Q9UBI1 COMMD3;COMMD3-BMI1 COMM domain-containing protein 3 0 21998600.0 6780800.0 7445800.0 7772000.0 False True 10286969.342882108 6117038.815699066 6235860.793411389 1.0 0.5946395494929365 0.6061902768016108 23.29431467482069 -10.146616144305513 6.205476540550074 1.000002022813121 0.6004149131472715 0.9993736891354641 0.004715564677388311 1.3196835078561054e-07 1.814540718797636e-08 0.004565848994335611 0.0015219419552895894 7.134833712165868e-11 10.146616144305513 -0.39958710966584954 SFDSNAFTLLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFDSNAFTLLLR 12 0 Q9UBI1;R4GMW6;H0Y6Z9;R4GMX3;H0Y4W0;R4GN54;R4GN06;Q5T8Z1 Q9UBI1 COMMD3;COMMD3-BMI1 COMM domain-containing protein 3 0 10510800.0 1808400.0 2589100.0 6113300.0 False True 2477014.3501724396 2474705.00099124 4669464.447365613 1.0 0.9990676884124475 1.885118044245704 21.240170795947467 -6.906658098737746 0.9181883768586317 0.9695827199674855 1.991804074054896 0.9895981295088407 0.042577435564302504 0.10667002996756934 0.15106056119028194 0.03429260281435758 0.0926087461749092 1.239772221491887e-07 6.906658098737746 1.0222213540874105 SFDSNAFTLLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFDSNAFTLLLR 12 0 Q9UBI1;R4GMW6;H0Y6Z9;R4GMX3;H0Y4W0;R4GN54;R4GN06;Q5T8Z1 Q9UBI1 COMMD3;COMMD3-BMI1 COMM domain-containing protein 3 0 8664700.0 4152700.0 2170000.0 2342000.0 False True 3453154.0458026216 2158309.779288725 2831701.3718154794 1.0 0.6250256289354349 0.8200333185996928 21.71948326382776 -10.10550197269666 4.83469746941334 1.0000126723198368 0.7225294737668153 0.729686681707304 0.07961155594069201 110893422.42848772 2.413411968839834 16221.10913451595 0.02725315314054647 7.84328556216763e-11 10.10550197269666 -0.2774831985530215 SFDSNAFTLLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFDSNAFTLLLR 12 0 Q9UBI1;R4GMW6;H0Y6Z9;R4GMX3;H0Y4W0;R4GN54;R4GN06;Q5T8Z1 Q9UBI1 COMMD3;COMMD3-BMI1 COMM domain-containing protein 3 0 18022900.0 6780800.0 5880400.0 5361700.0 False True 8777879.26955076 5553150.570712957 4385925.615687812 1.0 0.6326300920970812 0.49965663470697036 23.06544099691314 -13.999999999999998 0.141396646086154 2.757149420622939 0.3378314126233096 0.9995974243042097 0.004245678832913886 11.935682282603121 0.11791295819561226 5.78227409904296 0.1448096610574882 1.0000000000000041e-14 13.999999999999998 -2.4193180079996295 SFDVNKPGCEVDDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFDVNKPGCEVDDLK 15 1 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 0 7797200.0 1195900.0 3987900.0 2613400.0 False True 1638056.5479823186 3811701.3917782116 1996168.7446625023 1.0 2.326965693872588 1.218620167369246 20.643553730995094 -6.601991248680232 2.183820853764616 1.8912964977074036 1.2223373007070473 0.026099256099329393 0.5732749450384823 0.6350999012768849 5.727447218474339 0.2177047288148247 0.6372292644057971 2.5003957458094366e-07 6.601991248680232 -0.6689591970003563 SFDVNKPGCEVDDLK(ub)GGVAGGSILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFDVNKPGCEVDDLKGGVAGGSILK 25 2 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 244004000.0 30583000.0 34201000.0 179220000.0 True False 46396646.91678913 28097564.336367335 143797088.44508368 1.0 0.6055947186605833 3.0992991520050803 25.467517209837705 -6.866445567057425 1.1527997223899853 0.7811003714475295 3.235766521688704 0.9610014927813678 0.21614030982386162 0.14030485719081262 0.35073140909740896 0.14580622358018228 0.34321061897921973 1.360048616311415e-07 6.866445567057425 2.4546661502411746 up SFDVNKPGCEVDDLK(ub)GGVAGGSILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFDVNKPGCEVDDLKGGVAGGSILK 25 2 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 288598000.0 30583000.0 40945000.0 217070000.0 True False 39590296.38105697 38666374.75645237 177565487.32628706 1.0 0.9766629273064326 4.485075979659702 25.238643531930155 -6.905399368170785 0.9264733260873688 0.8749441219986968 4.896578797958645 0.9890671135686357 0.17235834592176397 0.10754017301277763 0.15584224902551524 0.13797783694751733 0.36977882863506073 1.243370708060092e-07 6.905399368170785 4.021634675959948 up SFDVNKPGCEVDDLKGGVAGGSILK(ub)GVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFDVNKPGCEVDDLKGGVAGGSILKGVLK 29 3 P41091;Q2VIR3;Q2VIR3-2 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 102943000.0 19850000.0 26383000.0 56710000.0 True False 30113901.229384437 21674747.518680133 45501243.64312396 1.0 0.7197588699510784 1.510971404751933 24.843926284253566 -6.810948430223573 1.4104112462019556 0.8474424849150003 1.5251346065329032 0.8623305159267229 0.12153633688976143 0.20550302749920835 0.8055064963359349 0.06775138910480276 0.15666625575074763 1.5454379398146804e-07 6.810948430223573 0.6776921216179029 SFEAPIK(ub)LVFPQDLLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFEAPIKLVFPQDLLEK 17 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2;A0A075B6F6;A0A0S2Z6F0;A0A3B3IT72;Q8TCT9-4 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 12235000.0 1720500.0 1490200.0 9024300.0 True False 2255592.1613457017 1267867.9687541046 8090552.003198119 1.0 0.5620998292517942 3.5868860256950175 21.10507480372994 -6.87014732834371 1.1332525922249568 0.7520927261793557 3.764577540584828 0.9648332559739604 0.25029555352904165 0.13671699854901584 0.3280619547902644 0.1713865188757578 0.40588810118734026 1.3485053433657495e-07 6.87014732834371 3.0124848144054726 up SFEAPIK(ub)LVFPQDLLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFEAPIKLVFPQDLLEK 17 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2;A0A075B6F6;A0A0S2Z6F0;A0A3B3IT72;Q8TCT9-4 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 95159900.0 3887800.0 6560100.0 84712000.0 True False 3764383.917074128 9179582.14046956 62523385.89447409 1.0 2.438535054523451 16.609194830231466 21.84398234059308 -6.9264420285850035 0.7754369608093973 0.7537206305892072 19.27124937693062 0.9957916461000744 0.4569379710319414 0.09452779023059239 0.08704148975620297 0.4077974819397128 1.308179985529051 1.184562476719404e-07 6.9264420285850035 18.517528746341412 SFEAPIK(ub)LVFPQDLLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFEAPIKLVFPQDLLEK 17 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2;A0A075B6F6;A0A0S2Z6F0;A0A3B3IT72;Q8TCT9-4 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 284807900.0 4306900.0 109750000.0 170751000.0 True False 6533882.176566041 90164255.01933613 137001990.00717813 1.0 13.799492029824606 20.967930903091542 22.63950900867063 -8.3655699312405 0.43481688118360345 3.3555519195606143e-18 22.324782384985244 0.9954636912949413 0.5562757172521734 0.1544414552871636 0.13560806154129207 1.6409623452832374 1.686182111935265 4.309531592058312e-09 8.3655699312405 22.324782384985244 SFEAPIK(ub)LVFPQDLLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFEAPIKLVFPQDLLEK 17 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2;A0A075B6F6;A0A0S2Z6F0;A0A3B3IT72;Q8TCT9-4 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 44334200.0 1720500.0 1907600.0 40706100.0 True False 2356615.344764261 1823315.9244103727 31092157.548445072 1.0 0.7737011169265573 13.193564922473723 21.168284865252833 -6.902751037739163 0.943710340755385 0.521877650857574 14.572601141927795 0.9878860289213335 0.6386077589083324 0.10940859280966443 0.16621851138649416 0.5047795340791099 1.3324417635412595 1.2509759551681174e-07 6.902751037739163 14.05072349107022 up SFEAPIK(ub)LVFPQDLLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFEAPIKLVFPQDLLEK 17 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2;A0A075B6F6;A0A0S2Z6F0;A0A3B3IT72;Q8TCT9-4 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 53312900.0 3887800.0 6299000.0 43126100.0 True False 3232877.9587428533 6265066.036746395 52143568.11744305 1.0 1.9379222218405818 16.129148326316578 21.624387616027356 -6.920320777730483 0.8223556337419746 0.6904839436269096 18.434494437139122 0.9942693125616558 0.5239649144368127 0.09798337828210224 0.10464270794182068 0.45221708487619733 1.3587632341456057 1.201376748311657e-07 6.920320777730483 17.744010493512214 up SFEAPIK(ub)LVFPQDLLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFEAPIKLVFPQDLLEK 17 1 A0A3B3IUB5;Q8TCT9-5;Q8TCT9;Q8TCT9-2;A0A075B6F6;A0A0S2Z6F0;A0A3B3IT72;Q8TCT9-4 A0A3B3IUB5 HM13 Minor histocompatibility antigen H13 1 154073900.0 4306900.0 46661000.0 103106000.0 True False 5575366.951691278 44064274.33168451 84341765.95689948 1.0 7.90338550152608 15.127572173758812 22.41063533076308 -7.43411051602189 0.3387201387018572 7.14991293654212e-17 19.876295083319928 0.9993762254609214 0.14405988054602192 0.1397616709156994 0.039292804468172716 0.3938721106838219 1.351828018899082 3.680353068442094e-08 7.43411051602189 19.876295083319928 SFEEAFQK(ub)ALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFEEAFQKALR 11 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 1 17658900.0 2443300.0 3027600.0 12188000.0 True False 3706664.7291564206 2487301.125253231 9779036.45780984 1.0 0.6710348269937276 2.638230639228975 21.821690197441058 -6.863906967024547 1.1657575580587591 0.8192864967639277 2.7408881661735744 0.9582193800294867 0.1758589567796522 0.1428355927288371 0.36664564240231295 0.11745252541324055 0.27550605314528986 1.3680218468461617e-07 6.863906967024547 1.9216016694096467 up SFEVNLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFEVNLR 7 0 J3QS36;Q7Z4W1;J3KS22;J3QL34;J3KSZ5;J3QS45;J3KRZ4 J3QS36 DCXR L-xylulose reductase 0 11342000.0 2278200.0 2867200.0 6196600.0 False True 2986742.262120184 2439424.9362580646 5555435.27398441 1.0 0.8167510692825574 1.8600316955507237 21.510141316445843 -6.861547363771568 1.177783841345837 0.9001277260119093 1.9120922301653354 0.9555003432945157 0.09594190251618165 0.14522236857551624 0.38189890019663386 0.0634900496592826 0.14848330121351921 1.3754747940322736e-07 6.861547363771568 1.011964504153426 SFEVVFNDPEKVYGSGEK(ub)VAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFEVVFNDPEKVYGSGEKVAGR 22 2 Q9H3M7 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 170429000.0 46652000.0 91414000.0 32363000.0 True False 70774494.7180475 75100457.47915806 25966438.864793207 1.0 1.0611231882098826 0.3668897809618945 26.076726208513957 -6.88544005036147 1.0489604757713298 1.0414805135919014 0.31224823780026295 0.9778163357399885 0.04674560487440138 0.12292180466014083 0.24407437192840498 0.03414172732344474 0.08383364501553595 1.3018470090233726e-07 6.88544005036147 -0.7292322757916385 down SFEVVFNDPEKVYGSGEK(ub)VAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFEVVFNDPEKVYGSGEKVAGR 22 2 Q9H3M7 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 155641000.0 46652000.0 88681000.0 20308000.0 True False 60391933.648401715 83745824.39313586 16612152.377676494 1.0 1.386705464353884 0.2750723709956278 25.847852530606406 -6.81275308393645 1.4029880684202545 1.2100781123374618 0.25438817039616324 0.8668698444037594 0.1681215429772781 0.20307793428672288 0.7873103690618184 0.09421054048840609 0.2176632665015833 1.5390293994596808e-07 6.81275308393645 -0.9556899419412985 down SFEWLSQMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFEWLSQMR 9 0 Q14204 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 3979070.0 913570.0 1781400.0 1284100.0 False True 1197699.1170244645 1515622.0638428149 1151233.6499569742 1.0 1.2654447534437452 0.961204390646185 20.19183409272911 -6.676185609154239 1.9161754478069684 1.168528413251227 0.9624142981365728 0.3064743891439963 0.11259787375835781 0.44702805579629695 3.17020894422922 0.04721725499083393 0.1251105742724177 2.1077271551442167e-07 6.676185609154239 -0.20611411511465427 SFFQIMFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFFQIMFK 8 0 Q9Y2P8;Q5VZU3;Q9Y2P8-2 Q9Y2P8 RCL1 RNA 3-terminal phosphate cyclase-like protein 0 3417480.0 948480.0 1340100.0 1128900.0 False True 1243466.4650933852 1140162.303668886 1012092.2571734504 1.0 0.9169224387432587 0.8139280676921525 20.245936169524068 -6.9682305953637105 0.29743436559947467 1.0184161484954386 0.7092188660713207 0.9999650954041452 0.0004496125928477032 0.07688116355019325 0.01107457310433714 0.0017308336915919378 0.009262529885116237 1.0758937995105084e-07 6.9682305953637105 -0.3091972824241179 SFFQIMFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFFQIMFK 8 0 Q9Y2P8;Q5VZU3;Q9Y2P8-2 Q9Y2P8 RCL1 RNA 3-terminal phosphate cyclase-like protein 0 3801700.0 1424200.0 1077800.0 1299700.0 False True 1378989.550567666 1508171.1606527476 959269.5798357725 1.0 1.09367845465682 0.6956322326306865 20.395180094050378 -6.844673090976682 1.260548902238412 1.0498461454902355 0.6812842907383312 0.932186690722726 0.044248926664481825 0.1634134320583398 0.5023684777670792 0.027501966536036548 0.06346038918788059 1.429969943126032e-07 6.844673090976682 -0.3685618547519043 SFFQIMFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFFQIMFK 8 0 Q9Y2P8;Q5VZU3;Q9Y2P8-2 Q9Y2P8 RCL1 RNA 3-terminal phosphate cyclase-like protein 0 7146900.0 3991900.0 3155000.0 0.0 False True 6056004.146981341 2591965.5998724876 0.0 1.0 0.4279993105956626 0.0 22.52993476256515 -8.172790837077352 0.5516616193961377 1.024752842248168 6.699881602462642e-16 0.9909956680588747 0.038872807284726696 0.1243557442051727 0.171962767122845 0.05242355453853985 0.07351402820883214 6.717523013027336e-09 8.172790837077352 -1.0247528422481673 SFFQIMFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFFQIMFK 8 0 Q9Y2P8;Q5VZU3;Q9Y2P8-2 Q9Y2P8 RCL1 RNA 3-terminal phosphate cyclase-like protein 0 4186780.0 948480.0 1352500.0 1885800.0 False True 1299158.6877082267 1292742.077880598 1440412.879270126 1.0 0.9950609499144805 1.1087274348379088 20.30914623104696 -6.896742868326944 0.9816433976686525 0.9948426195846349 1.1198993557741344 0.9848745436068089 0.006451516264227215 0.11384222536022433 0.19125550759812224 0.004957841504841407 0.01270087132887729 1.2684026236293182e-07 6.896742868326944 0.12505673618949942 SFFQIMFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFFQIMFK 8 0 Q9Y2P8;Q5VZU3;Q9Y2P8-2 Q9Y2P8 RCL1 RNA 3-terminal phosphate cyclase-like protein 0 3585220.0 1424200.0 760120.0 1400900.0 False True 1184285.4027577473 756025.0826879927 1693821.7129702414 1.0 0.638380816758781 1.4302479022590155 20.175585369484654 -6.782530560101799 1.5258360934632378 0.7959124388568264 1.4370440552628212 0.7762791307298933 0.15309919665719074 0.2466735987560623 1.1344628881760626 0.07901236775538602 0.1860592930223047 1.6499448951753245e-07 6.782530560101799 0.6411316164059948 SFFSLTEIIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFFSLTEIIR 10 0 P17927 P17927 CR1 Complement receptor type 1 0 7300700.0 0.0 0.0 7300700.0 False True 0.0 0.0 5388427.653694718 0.0 SFFTDDDKQDHLSWEWNLSIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFFTDDDKQDHLSWEWNLSIK 21 1 P52566;H0YGX7 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 97341000.0 31073000.0 28741000.0 37527000.0 False True 47140012.74058759 23611943.995542027 30109772.001331586 1.0 0.5008896396672401 0.6387306716912923 25.490448812718583 -10.455416586662539 9.152067649168506 1.0000044626817217 0.5698101556792862 0.9285039958798409 0.0562733656795939 5.124146370616139e-06 3.0500313016344566e-07 0.05448701663843328 0.018162150676008945 3.504155848661019e-11 10.455416586662539 -0.43019430700243555 SFFTDDDKQDHLSWEWNLSIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFFTDDDKQDHLSWEWNLSIK 21 1 P52566;H0YGX7 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 57308900.0 31073000.0 3820200.0 22415700.0 False True 40224611.04040103 3607602.511774313 18336272.604504775 1.0 0.08968644863093614 0.4558471077840401 25.261575134811032 -10.619001441558826 6.476262082195937 1.0024787184089972 0.27276677948037553 0.8402423161629724 0.14948446313437594 0.005360835809581555 0.00031537767584309914 0.14503228985013025 0.04824590301968288 2.4043548191902136e-11 10.619001441558826 -0.7297119389286216 SFGGGCHVTAAVSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFGGGCHVTAAVSSR 15 0 Q9NRA8;Q9NRA8-3;B1AKL5;B1AKL4 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 0 4793000.0 1789000.0 1266000.0 1738000.0 False True 2345396.3247006442 1077117.7348293492 1558168.4320732162 1.0 0.45924764334523616 0.6643518690906509 21.161400299044868 -10.146714997715016 5.284578209526456 1.0000135650464503 0.5617997562177136 0.8588774395932611 0.08373344952828914 1.3382751398195002e-05 2.160837063262143e-06 0.08107707150538616 0.027024854628513544 7.133209877638301e-11 10.146714997715016 -0.43821380882873673 SFGGGCHVTAAVSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFGGGCHVTAAVSSR 15 0 Q9NRA8;Q9NRA8-3;B1AKL5;B1AKL4 Q9NRA8 EIF4ENIF1 Eukaryotic translation initiation factor 4E transporter 0 4266000.0 1789000.0 1143000.0 1334000.0 False True 2450441.6459071552 1092498.480604453 1018936.6745924017 1.0 0.4458373789186926 0.4158175634560727 21.22461036056776 -13.849633512956691 0.4164943151422475 9.999383396785316 0.41469086148153117 0.9998576836395039 0.003204180394970537 25.72129921590926 0.2145277835106597 209.4643158721184 0.007352741822266461 1.4137300423786017e-14 13.849633512956691 -9.584692535303784 SFGGGTGSGFTSLLMER ddPTM_RPMI8226_Bortezomib_1h_R1 2 SFGGGTGSGFTSLLMER 17 0 A6NHL2-2;A6NHL2 A6NHL2-2 TUBAL3 Tubulin alpha chain-like 3 0 69624200.0 11028000.0 12831100.0 45765100.0 False True 14457814.795303904 10916749.895236067 41029766.461837746 1.0 0.7550760643843617 2.8378954249133677 23.78534617900315 -6.877581503384323 1.0932428139513366 0.852565491924433 2.9787997952325003 0.9716797086882397 0.15642468070610147 0.12979186138046772 0.28544010434917266 0.11045264049376416 0.26552735760475993 1.3256183176435431e-07 6.877581503384323 2.1262343033080673 up SFGGGTGSGFTSLLMER ddPTM_RPMI8226_Bortezomib_2h_R1 2 SFGGGTGSGFTSLLMER 17 0 A6NHL2-2;A6NHL2 A6NHL2-2 TUBAL3 Tubulin alpha chain-like 3 0 42239400.0 7890300.0 4493800.0 29855300.0 False True 7639826.745431858 6288197.774857414 22035301.29019843 1.0 0.8230812012350104 2.8842671469446834 22.86510849078671 -6.886021987306938 1.0456614028944595 0.8784590706957889 3.0483037969792806 0.9782262862209732 0.13763624834180788 0.122428731710007 0.24119440235403314 0.10078166774833681 0.24790135740084393 1.3001037551754485e-07 6.886021987306938 2.1698447262834915 up SFGGGTGSGFTSLLMER ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SFGGGTGSGFTSLLMER 17 0 A6NHL2-2;A6NHL2 A6NHL2-2 TUBAL3 Tubulin alpha chain-like 3 0 31409310.0 11028000.0 11217910.0 9163400.0 False True 15105349.620494178 10722265.643532386 6999193.6461469345 1.0 0.7098323384044654 0.4633585995686443 23.84855624052604 -7.095810506569348 0.18088746153000032 1.1966517997436266 1.1496976940660428e-10 0.9999959629253666 0.0004406400669018151 0.07611163420882698 0.006381648825502555 0.01106619579122169 0.029344618837778776 8.020279316897247e-08 7.095810506569348 -1.1966517996286568 down SFGGGTGSGFTSLLMER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFGGGTGSGFTSLLMER 17 0 A6NHL2-2;A6NHL2 A6NHL2-2 TUBAL3 Tubulin alpha chain-like 3 0 10902800.0 4982200.0 2922200.0 2998400.0 False True 4142920.0488833333 2906457.5285887155 3625351.5769647914 1.0 0.7015480613419298 0.8750715761319011 21.98221654841694 -10.214874513850775 5.278886116298281 1.0000151744210402 0.7883098193245547 0.6649213348963087 0.07084067826846227 1.2652351280584756e-05 1.8818513011655106e-06 0.06859610594917298 0.022863730597290688 6.09713043824293e-11 10.214874513850775 -0.21170535509648547 SFGSTCQLSEK(ub)FIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFGSTCQLSEKFIK 14 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 5607010.0 855510.0 1612000.0 3139500.0 True False 1121581.8947706253 1371495.883526784 2814654.656210509 1.0 1.2228227737282336 2.5095400249717246 20.09710353514817 -6.936651407031477 0.69002047939219 0.9843844868550321 2.82481019235318 0.9976914737527594 0.031967298773944886 0.08932815852189538 0.06182039239738479 0.030378352557897014 0.11247589057101666 1.1570405855180745e-07 6.936651407031477 1.8404257054981477 up SFGSTCQLSEK(ub)FIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFGSTCQLSEKFIK 14 1 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 1 4158210.0 855510.0 1137700.0 2165000.0 True False 1171815.1662884464 1087432.6521292103 1653671.589574622 1.0 0.9279899112191 1.4112051432244093 20.160313596671063 -6.86897242875065 1.139457757767678 0.9595125274460513 1.4389646124080084 0.9636499666101427 0.04058260238709629 0.13784710430960812 0.33513631517985537 0.027656506283291193 0.06536654656919079 1.352158402445447e-07 6.86897242875065 0.4794520849619571 SFHILAIATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFHILAIATK 10 0 Q96EE3;Q96EE3-1;K7ELV2 Q96EE3 SEH1L Nucleoporin SEH1 0 19300800.0 5474300.0 6505100.0 7321400.0 False True 7176860.313196606 5534564.436681202 6563851.759827883 1.0 0.7711679195573031 0.914585413869413 22.774921410415782 -10.394154776927541 5.471280573138523 1.0000761181628801 0.8428766667999698 0.6154368548634057 0.058549946875534796 5.438995485302494e-05 6.022737956599974e-06 0.05671815438569706 0.018896914097522203 4.035015646091392e-11 10.394154776927541 -0.15719945136291036 SFHILAIATK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFHILAIATK 10 0 Q96EE3;Q96EE3-1;K7ELV2 Q96EE3 SEH1L Nucleoporin SEH1 0 16822800.0 6931400.0 3716100.0 6175300.0 False True 6711366.501056537 5199958.109205493 4557803.674971025 1.0 0.7747987102756032 0.6791170880406416 22.678175112736394 -13.999999999801442 0.11701159352137575 2.0761666129078216 0.520067968752087 0.9997077214660464 0.002299596465646199 11.976198871213422 0.10487740135761169 3.009620919183133 0.141130576153029 1.0000000004571959e-14 13.999999999801442 -1.5560986441557345 SFHILAIATK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFHILAIATK 10 0 Q96EE3;Q96EE3-1;K7ELV2 Q96EE3 SEH1L Nucleoporin SEH1 0 33715800.0 7096800.0 11219000.0 15400000.0 False True 10766364.445576591 9216881.795552908 12356183.249940228 1.0 0.8560811629723072 1.1476653342360912 23.36002783129 -6.772541772576919 1.5651628586191608 0.9177184862296207 1.1494478466152245 0.7400253918151805 0.06069679135366772 0.26234367574843137 1.2687453487867548 0.030563594620643748 0.0725726769391124 1.6883334594699e-07 6.772541772576919 0.23172936038560377 SFHILAIATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFHILAIATK 10 0 Q96EE3;Q96EE3-1;K7ELV2 Q96EE3 SEH1L Nucleoporin SEH1 0 17607100.0 5474300.0 5612800.0 6520000.0 False True 7498296.64739493 5364807.936952478 4980110.283615028 1.0 0.7154702180016215 0.6641655455636348 22.838131471938674 -13.999999999999998 0.24093936685031914 2.891923617047204 0.6416826742782722 0.9995265271259108 0.0032141619253277754 13.656810613485137 0.1553527355207069 12.4383334543909 0.024931862334155966 1.0000000000000041e-14 13.999999999999998 -2.2502409427689316 SFHILAIATK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFHILAIATK 10 0 Q96EE3;Q96EE3-1;K7ELV2 Q96EE3 SEH1L Nucleoporin SEH1 0 13877500.0 6931400.0 2654600.0 4291500.0 False True 5763766.213084574 2640299.1429031547 5188832.808345915 1.0 0.4580857455511117 0.9002503947100634 22.45858038817067 -10.025323808650919 7.156429331519235 1.0000000339684945 0.6791680701305907 0.4124496597033418 0.1805129621226962 9.793934002861704e-08 1.3101479650068078e-08 0.1747809422499597 0.058260308006314335 9.433572496981488e-11 10.025323808650919 -0.3208319638379038 SFHILAIATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFHILAIATK 10 0 Q96EE3;Q96EE3-1;K7ELV2 Q96EE3 SEH1L Nucleoporin SEH1 0 32675800.0 7096800.0 11744000.0 13835000.0 False True 9186947.498842001 11090436.0761943 11317171.959087765 1.0 1.207194890097307 1.2318751098244847 23.13115415338245 -12.987523593846657 0.3144206817766077 5.1628703487160306e-08 1.2372578104751677 0.999625741291926 0.0020115474179092613 9.432375135951169 0.17568040090541814 6.061580508790317 0.00840275889442376 1.0291446155012396e-13 12.987523593846657 1.2372577588464642 SFHPEQDAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFHPEQDAGK 10 0 U3KQC1;A0A0A0MQU0;Q9BV38;K7EIR0;K7EML4 U3KQC1 WDR18 WD repeat-containing protein 18 0 2343710.0 400250.0 946790.0 996670.0 False True 524731.6260265142 805532.6225585135 893544.1491337239 1.0 1.5351325946528915 1.702859337638959 19.001220219509218 -11.419257043939204 0.20943227331514402 2.4316855504797512e-08 1.8184323486759169 0.9993567651455049 0.007601620963232982 3.882031147884289 0.12178570029511092 1.8755715141688898 0.09864974226659169 3.808403503948538e-12 11.419257043939204 1.8184323243590614 SFHPEQDAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFHPEQDAGK 10 0 U3KQC1;A0A0A0MQU0;Q9BV38;K7EIR0;K7EML4 U3KQC1 WDR18 WD repeat-containing protein 18 0 1721960.0 639880.0 344910.0 737170.0 False True 619567.359652603 482634.3616818892 544083.0623740365 1.0 0.778986100805095 0.8781661168837377 19.24090161580814 -10.142549035551758 4.733228275319957 1.0000149816672292 0.8285761088429435 0.7993260903432027 0.04049007201734092 6.401866055968365e-06 1.15976376607177e-06 0.039207769111282806 0.013068114550108157 7.201964303268923e-11 10.142549035551758 -0.17143887282428572 SFHPEQDAGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFHPEQDAGK 10 0 U3KQC1;A0A0A0MQU0;Q9BV38;K7EIR0;K7EML4 U3KQC1 WDR18 WD repeat-containing protein 18 0 3307160.0 459570.0 1854800.0 992790.0 False True 697201.289067416 1523796.448381455 796564.6213446851 1.0 2.185590405920938 1.142517424788727 19.41121571132647 -6.615268654853598 2.133979238251856 1.7892637742947963 1.1463778155535045 0.06714643805613907 0.5104611369597998 0.5982668296072833 5.170089019204621 0.19699793762965448 0.5663703994085267 2.425109456669283e-07 6.615268654853598 -0.6428859587412918 SFHPEQDAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFHPEQDAGK 10 0 U3KQC1;A0A0A0MQU0;Q9BV38;K7EIR0;K7EML4 U3KQC1 WDR18 WD repeat-containing protein 18 0 2400420.0 400250.0 1188600.0 811570.0 False True 548233.2413495472 1136083.7218254188 619893.880808812 1.0 2.0722634749925075 1.1307119562521653 19.06443028103211 -6.614843493219611 2.136181713323541 1.7140567376027063 1.1342301849898575 0.06557404622336538 0.46172467965987646 0.5994191226226344 5.190424345334741 0.17807184280169885 0.512137578153067 2.427484730584708e-07 6.614843493219611 -0.5798265526128488 SFHPEQDAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFHPEQDAGK 10 0 U3KQC1;A0A0A0MQU0;Q9BV38;K7EIR0;K7EML4 U3KQC1 WDR18 WD repeat-containing protein 18 0 1296430.0 639880.0 343810.0 312740.0 False True 532088.5714903993 341957.8272890579 378132.488053618 1.0 0.6426708740073512 0.7106570377831181 19.021306891242418 -10.76474346408286 7.002966181038678 1.0072804887158182 0.6766639558954374 0.9679057534414773 0.02775523513665302 0.003182146716896569 0.00010690039764597683 0.027105747273160338 0.008957963621194012 1.7189234481565526e-11 10.76474346408286 -0.33061653282038084 SFICNYK(ub)EHWFTVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFICNYKEHWFTVR 14 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;A0A087X1A8;D3VVH9;A0A087WXY4;S4R399;F5H211;G3V3T0;G3V5H3;G3V4F4;G3V4F5 P54252-1 ATXN3 Ataxin-3 1 453986900.0 108014000.0 211861000.0 134111900.0 True False 141607400.0090639 180252164.62770978 120235287.08018427 1.0 1.272900742589528 0.8490748864288754 27.077321417721972 -6.732835535332346 1.7128419411128726 1.1637091906432302 0.8491912795455198 0.5723804853184327 0.11469765027526106 0.3309491861025573 1.9034180935747482 0.05303782168334923 0.13119184185217886 1.8499690583265517e-07 6.732835535332346 -0.31451791109771043 SFICNYK(ub)EHWFTVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFICNYKEHWFTVR 14 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;A0A087X1A8;D3VVH9;A0A087WXY4;S4R399;F5H211;G3V3T0;G3V5H3;G3V4F4;G3V4F5 P54252-1 ATXN3 Ataxin-3 1 191967700.0 42570000.0 82029700.0 67368000.0 True False 41218638.65163984 114784586.98923436 49722299.803320944 1.0 2.7847738485333933 1.2063062107302953 25.29679352127306 -6.616610562675286 2.1295837706982894 2.1870590551886226 1.2122504752948544 0.07144238225505273 0.7681812909335053 0.5945251760901118 5.118770062459845 0.2969148235240764 0.8519092818081186 2.41762777997662e-07 6.616610562675286 -0.9748085798937682 SFICNYK(ub)EHWFTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFICNYKEHWFTVR 14 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;A0A087X1A8;D3VVH9;A0A087WXY4;S4R399;F5H211;G3V3T0;G3V5H3;G3V4F4;G3V4F5 P54252-1 ATXN3 Ataxin-3 1 2215174000.0 372420000.0 1140190000.0 702564000.0 True False 564988367.548985 936714186.1548697 563701917.4552598 1.0 1.6579353486842465 0.997723050300476 29.073645923525568 -6.6469634589007685 2.0192786295387712 1.4279552229621997 1.0004893031413211 0.18185721956571776 0.28102457596106584 0.5160202252146511 4.029422261983832 0.11300215998757686 0.3112521951226494 2.2544288895433175e-07 6.6469634589007685 -0.42746591982087856 SFICNYK(ub)EHWFTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFICNYKEHWFTVR 14 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;A0A087X1A8;D3VVH9;A0A087WXY4;S4R399;F5H211;G3V3T0;G3V5H3;G3V4F4;G3V4F5 P54252-1 ATXN3 Ataxin-3 1 511670000.0 108014000.0 168242000.0 235414000.0 True False 147949694.7685944 160808512.13810548 179814061.70351973 1.0 1.0869134430430785 1.2153729819095864 27.140531479244864 -6.965501391754089 0.34933971664452285 0.9874912432998293 1.3191254797509941 0.9999231074258977 0.0007757515725846833 0.07779120948084342 0.014262288056636197 0.0017662889553288158 0.011046302288327835 1.0826762455425607e-07 6.965501391754089 0.33163423645116485 SFICNYK(ub)EHWFTVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFICNYKEHWFTVR 14 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;A0A087X1A8;D3VVH9;A0A087WXY4;S4R399;F5H211;G3V3T0;G3V5H3;G3V4F4;G3V4F5 P54252-1 ATXN3 Ataxin-3 1 323272000.0 42570000.0 56849000.0 223853000.0 True False 35398841.170760594 56542743.15335701 270659627.3206711 1.0 1.5973049196893274 7.646002478302472 25.077198796707336 -6.925991294307754 0.7789943432242625 0.8930764623240655 8.769843064235783 0.9956900297907013 0.19708825667455668 0.09477328559248384 0.08827368694253085 0.1754462490880219 0.5598494965218314 1.1857925178480841e-07 6.925991294307754 7.876766601911717 up SFICNYK(ub)EHWFTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFICNYKEHWFTVR 14 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;A0A087X1A8;D3VVH9;A0A087WXY4;S4R399;F5H211;G3V3T0;G3V5H3;G3V4F4;G3V4F5 P54252-1 ATXN3 Ataxin-3 1 1683881700.0 372420000.0 998541700.0 312920000.0 True False 482105031.4957079 942971976.6063013 255971770.83033928 1.0 1.9559471795612164 0.5309460679889588 28.844772245618017 -6.72590722377168 1.7377986293030296 1.5778743688447368 0.5323437385794603 0.5403803645357574 0.4020025897797121 0.34394559820184556 2.032867591059859 0.1834509649799052 0.45740723957006835 1.8797183290445713e-07 6.72590722377168 -1.0455306302652765 SFIK(ub)QTYQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFIKQTYQK 9 1 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 1088700.0 421500.0 0.0 667200.0 True False 552590.5818118058 0.0 598164.5442343223 1.0 0.0 1.0824732884029453 19.07585144793504 -10.884569719110996 5.093139879802436 1.118491215337021 0.5412366442014725 0.19321456119677405 0.4419178694632991 0.2557699747808187 0.005796734735359904 0.1840610387565783 0.14262837906856823 1.3044585416405192e-11 10.884569719110996 -0.5772545711355485 SFIK(ub)QTYQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFIKQTYQK 9 1 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 3446300.0 1094000.0 2352300.0 0.0 True False 1659677.9821131765 1932513.6863962146 0.0 1.0 1.1643907476169875 0.0 20.66247192012844 -6.929962129947785 1.240282315512424 1.087844208263097 2.199272776317014e-21 0.9640520125202264 0.09755793004259904 0.11695787044031776 0.35932646698388165 0.06493227180428365 0.12560127697961865 1.1750000093191163e-07 6.929962129947785 -1.087844208263097 down SFIK(ub)QTYQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFIKQTYQK 9 1 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 3761470.0 634470.0 1987000.0 1140000.0 True False 527589.9167867634 1976295.63661138 1378368.7292355453 1.0 3.7458934936585258 2.6125759522289016 19.00905746673525 -9.897954647463937 7.006561103526224 0.9999999587155681 3.179234722943726 0.8313648434889428 0.46267494884139704 2.980976442279383e-07 4.763726582613954e-08 0.4479830928923016 0.14932769763083492 1.2648684283477185e-10 9.897954647463937 2.1792347642281578 SFINYQFMSSHIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFINYQFMSSHIK 13 0 Q86T24 Q86T24 ZBTB33 Transcriptional regulator Kaiso 0 6992000.0 2106300.0 2066800.0 2818900.0 False True 2761379.6974382135 1758441.4963233022 2527227.268798158 1.0 0.6367981549059128 0.9152045519646272 21.396957845496537 -9.787452068948806 5.8364573380270555 1.0000000187612221 0.7760013534343173 0.4632658759289964 0.11365893565680256 2.772922609687068e-08 5.900371824835133e-09 0.11004979943447557 0.03668326374504466 1.6313529440890387e-10 9.787452068948806 -0.22399866532690482 SFINYQFMSSHIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFINYQFMSSHIK 13 0 Q86T24 Q86T24 ZBTB33 Transcriptional regulator Kaiso 0 8475400.0 1498600.0 1977500.0 4999300.0 False True 1451027.7632921683 2767126.0625262656 3689833.3542148005 1.0 1.9070111079391507 2.542910237529234 20.468643692850637 -7.901285052045315 0.14749146503211408 2.57812809887172e-21 3.8689567425855578 0.999959908248557 0.004008810539727536 0.12157903989437287 0.022987910782128758 0.23785736788483378 0.3083424259127329 1.2552058306427932e-08 7.901285052045315 3.8689567425855578 SFINYQFMSSHIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFINYQFMSSHIK 13 0 Q86T24 Q86T24 ZBTB33 Transcriptional regulator Kaiso 0 6552900.0 2106300.0 1778700.0 2667900.0 False True 2885056.0306172376 1700111.1526256725 2037796.9671252372 1.0 0.5892818491507583 0.7063283851333955 21.46016790701943 -10.388881183720642 8.689494843398226 1.0000017237299945 0.6478051171420789 0.9235019876139262 0.047784048219628644 1.5956915191563645e-06 1.1226770517856348e-07 0.04626693181998469 0.015422235247416158 4.0843111150853e-11 10.388881183720642 -0.35219660658791563 SFINYQFMSSHIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFINYQFMSSHIK 13 0 Q86T24 Q86T24 ZBTB33 Transcriptional regulator Kaiso 0 4542600.0 1498600.0 1560500.0 1483500.0 False True 1246152.2992365973 1552093.2767650008 1793692.9910709949 1.0 1.2455084966065748 1.4393850512251394 20.249048968284914 -6.973783526887873 0.14105326420510103 0.7442152102862294 1.9457396261422273 0.9999988878373233 0.00018951761208720492 0.07509300975884842 0.004275645450754125 0.010838818773101607 0.025129327528443185 1.0622248888832299e-07 6.973783526887873 1.201524415855998 SFIPSLVEK(ub)EK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFIPSLVEKEK 11 1 Q14137;Q14137-2;A0A075B729 Q14137 BOP1 Ribosome biogenesis protein BOP1 1 7376000.0 1908300.0 3199400.0 2268300.0 True False 2613850.0798684307 3058039.928999031 1732574.2571049028 1.0 1.1699370031019372 0.6628437761021522 21.317744965532896 -6.816331725086622 1.387644370922495 1.0919486082665009 0.6526182918193334 0.8757436107701524 0.07428536330073744 0.19829130789515592 0.7512204876111412 0.0420779996481895 0.09709183216207287 1.5263997102276287e-07 6.816331725086622 -0.43933031644716747 SFIPSLVEK(ub)EK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFIPSLVEKEK 11 1 Q14137;Q14137-2;A0A075B729 Q14137 BOP1 Ribosome biogenesis protein BOP1 1 9103600.0 3003800.0 4072500.0 2027300.0 True False 2497792.7909027683 4050560.6341720396 2451199.0568238804 1.0 1.621655987207834 0.981346037089791 21.25222236975435 -6.652883256780223 1.9979652375565766 1.4024608900173112 0.9840206271660407 0.2059551721117039 0.26514056821412063 0.5014906805584267 3.8402953229737746 0.10749660630218585 0.29377867381323386 2.2239076215804553e-07 6.652883256780223 -0.41844026285127056 SFITWLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFITWLR 7 0 O95487-2;O95487;O95487-3 O95487-2 SEC24B Protein transport protein Sec24B 0 27136900.0 6917400.0 4920500.0 15299000.0 False True 9068778.38819688 4186380.579958775 13716006.238370618 1.0 0.46162563476106083 1.5124425420100858 23.11247679461071 -6.767438275259429 1.5842303598409846 0.6901919467180289 1.5177925097927427 0.7206678568726835 0.22675452328944531 0.27059704375404525 1.3399026508976914 0.11284630898413675 0.26926050143926344 1.7082904961005372e-07 6.767438275259429 0.8276005630747139 SFITWLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFITWLR 7 0 O95487-2;O95487;O95487-3 O95487-2 SEC24B Protein transport protein Sec24B 0 25464600.0 7081600.0 3103000.0 15280000.0 False True 6856798.484271859 4342044.081931225 11277709.60982579 1.0 0.6332465642516717 1.644748585756841 22.70910369251764 -6.808609904930632 1.420394368902082 0.7997934564634572 1.661883309131615 0.8561640001363391 0.15857128579321803 0.20870032119423917 0.8301298559341644 0.08778953710624168 0.20320374122797005 1.5537820324567455e-07 6.808609904930632 0.8620898526681577 SFITWLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFITWLR 7 0 O95487-2;O95487;O95487-3 O95487-2 SEC24B Protein transport protein Sec24B 0 24633700.0 6917400.0 7362300.0 10354000.0 False True 9474949.715706058 7037009.24212964 7908598.4473236315 1.0 0.7426962098241862 0.8346850046300531 23.175686856133602 -10.90493778464873 10.588167138311025 1.0208153720280655 0.7886906072271197 0.875555123433249 0.03755426822132627 0.016126285404552715 0.00014478406152332464 0.03177700596047408 0.012120587950016911 1.2446929089020996e-11 10.90493778464873 -0.2321247648009458 SFITWLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFITWLR 7 0 O95487-2;O95487;O95487-3 O95487-2 SEC24B Protein transport protein Sec24B 0 15521200.0 7081600.0 3423100.0 5016500.0 False True 5888664.168072786 3404659.080867849 6065426.956324668 1.0 0.5781717183546077 1.0300174680040772 22.489508967951917 -11.81821461403018 13.711299299357922 0.9013224494461665 0.8236851338613613 0.0 0.21129505541453472 0.0 0.0 0.0 0.061365751945916876 1.5197963108491421e-12 11.81821461403018 -0.07763731558480513 SFK(ub)DEWTQLDMFYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFKDEWTQLDMFYR 14 1 Q9NRN7;E9PLW6;E9PNF3 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 5301110.0 2184700.0 933110.0 2183300.0 True False 2115347.8943443205 1305705.6891043663 1611428.2324039724 1.0 0.6172534043196175 0.761779297255242 21.012463520693444 -10.032086402891352 5.738563835923867 1.000000866171233 0.6895163521120271 0.8602090298331112 0.05900244871900852 6.538220873181528e-07 1.1022086221296161e-07 0.05712903450164907 0.019042958439474473 9.287815872918908e-11 10.032086402891352 -0.31048451405920585 SFK(ub)DEWTQLDMFYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFKDEWTQLDMFYR 14 1 Q9NRN7;E9PLW6;E9PNF3 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 17947100.0 2551900.0 2950200.0 12445000.0 True False 3303484.855469357 2786018.776565778 10180137.696483362 1.0 0.8433575143997268 3.081635951691679 21.655557300148235 -6.890109757860464 1.021712940378513 0.8800511948761133 3.2745777764512694 0.9809691621298046 0.1407416670105105 0.11905494220008735 0.22131793686403625 0.10494196062267529 0.2617307024719596 1.28792401762647e-07 6.890109757860464 2.394526581575156 up SFK(ub)DLQLLQGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFKDLQLLQGSK 12 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 6955740.0 880840.0 1757900.0 4317000.0 True False 852878.2163474397 2459838.637327394 3186248.1927760425 1.0 2.8841616425167573 3.735877094412798 19.701980226279325 -9.163840725200675 0.2721449860220434 3.074593541789734e-13 4.202685030048044 0.9989177005972381 0.03760672257989575 0.5935595191520059 0.09863570040750977 0.8969136786923421 0.3286458870589433 6.857396711000888e-10 9.163840725200675 4.2026850300477365 SFK(ub)DLQLLQGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFKDLQLLQGSK 12 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 5226290.0 1144700.0 789490.0 3292100.0 True False 1567926.524354344 754607.7213056949 2514573.7829277683 1.0 0.48127747670856874 1.6037574107391568 20.580426523271356 -6.781072631612389 1.5318732968530622 0.7066889644444839 1.6129184379619466 0.7710835014170152 0.21946057600082014 0.2489255040607259 1.1538785236363753 0.11283269473856673 0.26597979652200526 1.6554930748801255e-07 6.781072631612389 0.9062294735174626 SFKPDFGAESIYGGFLLGVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFKPDFGAESIYGGFLLGVR 20 1 P35606-2;P35606;H0Y938 P35606-2 COPB2 Coatomer subunit beta 0 53416000.0 11041000.0 17968000.0 24407000.0 False True 16750004.205220822 14761470.015375236 19582945.75203188 1.0 0.8812815707099477 1.169130796153953 23.997658121981974 -6.794732768259624 1.4776026746617374 0.9340540097804991 1.1725938824148836 0.8162249772800274 0.0506339176621104 0.22836949574268728 0.9848585372384879 0.026967129929087535 0.06291968322537919 1.604232209346446e-07 6.794732768259624 0.23853987263438448 SFKPDFGAESIYGGFLLGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFKPDFGAESIYGGFLLGVR 20 1 P35606-2;P35606;H0Y938 P35606-2 COPB2 Coatomer subunit beta 0 31328100.0 11041000.0 9149100.0 11138000.0 False True 14292792.150647407 8639944.54229473 9110998.285530876 1.0 0.6044966197807176 0.6374540530289726 23.768784444074424 -10.134885025631638 5.604774507755354 1.0000053689943678 0.6209753364047976 0.9943613208105269 0.01345481578184453 9.026877684305224e-07 1.393264954101461e-07 0.013027753816680435 0.004342523120756705 7.330185655183431e-11 10.134885025631638 -0.37903003258957013 SFLEDIRK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFLEDIRK 8 1 P52209-2;P52209;K7ELN9 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 6203330.0 981430.0 3179600.0 2042300.0 False True 1286664.2341816388 2705216.0739837294 1830982.3871249307 1.0 2.102503514216618 1.4230459963702158 20.29520418863207 -10.137497890245237 4.787638721530561 0.9999539123507672 1.762774755293283 0.6269181609265096 0.27738737018857196 193802442.9333783 13.521175732741996 120986.6675513285 0.09495707487366599 7.286217140686716e-11 10.137497890245237 0.7628208429425158 SFLEDIRK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFLEDIRK 8 1 P52209-2;P52209;K7ELN9 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 6044890.0 1598800.0 896690.0 3549400.0 False True 1548046.969138873 1254742.9931765771 2619705.660282438 1.0 0.8105328960881264 1.692264971611096 20.562017814137075 -6.850479357397166 1.2327185179002773 0.8988478076266764 1.7278514332488883 0.9410070567701252 0.09204654613208596 0.15693098578507025 0.4586495239558444 0.05842045876491413 0.1352351238141363 1.4109793006146266e-07 6.850479357397166 0.829003625622212 SFLEDIRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFLEDIRK 8 1 P52209-2;P52209;K7ELN9 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 13506200.0 4489800.0 3591100.0 5425300.0 False True 5812134.607189278 3391252.1281693974 4437951.068278923 1.0 0.5834779056862538 0.7635664636516558 22.470636685040223 -10.225221132047661 5.489829805136616 1.0000182158547217 0.6735221846689318 0.8141959787412469 0.07352084592155872 1.639249056126126e-05 2.3134194339811774e-06 0.0711902212828335 0.023728750987761456 5.953589242471529e-11 10.225221132047661 -0.32649603118578996 SFLFQLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFLFQLLK 8 0 Q00535 Q00535 CDK5 Cyclin-dependent-like kinase 5 0 22457900.0 4896500.0 9399900.0 8161500.0 False True 6419358.917773444 7997471.560523214 7317026.270636109 1.0 1.2458364866280351 1.1398375389756241 22.613997796215315 -10.230546110235965 4.729805172454306 0.9999557623178891 1.1928370128023795 0.815253486000622 0.04327388917228435 2.019267179476454e-05 3.2849836292690097e-06 0.04190936606069779 0.01396658767384234 5.881036702489465e-11 10.230546110235965 0.19288125048449045 SFLFQLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFLFQLLK 8 0 Q00535 Q00535 CDK5 Cyclin-dependent-like kinase 5 0 15287600.0 7094800.0 3093600.0 5099200.0 False True 6869579.457497178 4328890.612910876 3763566.5472790403 1.0 0.6301536563765199 0.547859817411623 22.711790352042385 -13.999999999999998 0.21117151389245215 3.1493194555591693 0.499935708052984 0.9994907011625076 0.004437595266308388 12.77434695947353 0.1456444141215245 11.3981496518859 0.04834967805544498 1.0000000000000041e-14 13.999999999999998 -2.649383747506185 SFLFQLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFLFQLLK 8 0 Q00535 Q00535 CDK5 Cyclin-dependent-like kinase 5 0 18559300.0 5331200.0 4691800.0 8536300.0 False True 8087820.162926673 3854511.632799288 6849096.563406797 1.0 0.4765822626061566 0.8468408576642202 22.94731948781407 -10.045949709081096 5.575054952429038 1.0000016233208169 0.6617115601350393 0.526743588928984 0.1511574384625481 3.049849428301867e-06 5.218505191126657e-07 0.14635826264099838 0.04878585348498971 8.996017485896915e-11 10.045949709081096 -0.3382900631857776 SFLFQLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFLFQLLK 8 0 Q00535 Q00535 CDK5 Cyclin-dependent-like kinase 5 0 39067600.0 4896500.0 8553100.0 25618000.0 False True 6706868.372937045 8175195.760680625 19567556.01927145 1.0 1.218928910796646 2.917539890633414 22.677207857738207 -6.930670762165419 0.7412696085654324 0.974801609290631 3.2722835553258838 0.9966683832455038 0.049466652473566 0.09229101877942632 0.07598588254279184 0.04524763351584386 0.15313200224616055 1.1730843415856561e-07 6.930670762165419 2.2974819460352527 up SFLFQLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFLFQLLK 8 0 Q00535 Q00535 CDK5 Cyclin-dependent-like kinase 5 0 15713900.0 7094800.0 2912900.0 5706200.0 False True 5899640.55293194 2897207.6295346203 6899340.037512176 1.0 0.4910820589052323 1.169450914104151 22.49219562747666 -6.705919573900086 1.8098501758284697 0.6858490033138922 1.1676732931242764 0.44583693897939813 0.21459418981414083 0.38324309042184296 2.444447220837981 0.09445276946961909 0.24114024359384392 1.9682507522585207e-07 6.705919573900086 0.48182428981038417 SFLFQLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFLFQLLK 8 0 Q00535 Q00535 CDK5 Cyclin-dependent-like kinase 5 0 17241200.0 5331200.0 5844800.0 6065200.0 False True 6901343.493662855 5519531.742007876 4961395.834207384 1.0 0.7997764126761949 0.7189028974957088 22.71844580990652 -13.999999999999632 0.1248691621375893 1.9519041101549073 0.5979030354699139 0.9996694216998214 0.0021482656088109 11.947662109249762 0.1093489894995269 2.805685815450812 0.1074464996592688 1.0000000000008466e-14 13.999999999999632 -1.3540010746849935 SFLHIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFLHIGK 7 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 15121100.0 4155100.0 2198800.0 8767200.0 False True 5447376.338045639 1870747.6108552716 7860054.244920787 1.0 0.343421767611239 1.4429064116654637 22.37713011013515 -6.744965249396752 1.6684257299230987 0.6115924910456538 1.444282832973799 0.6269968785503323 0.27585851975981446 0.3089360703321873 1.6903085639465003 0.13070157894337206 0.3190100539858953 1.7990148597403797e-07 6.744965249396752 0.8326903419281451 SFLHIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFLHIGK 7 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 8700300.0 3645400.0 1263100.0 3791800.0 False True 3529678.772391075 1767462.4169794847 2798613.8284383146 1.0 0.5007431358356076 0.7928806015802049 21.751105462575378 -10.241498643006365 5.778056120496619 1.0000146333140332 0.6468118687079036 0.6608837242259725 0.11926462097069333 2.2483073984056594e-05 2.9515167025239096e-06 0.11548225206999706 0.03849249090093392 5.734576583651316e-11 10.241498643006365 -0.35320276460612954 SFLHIGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFLHIGK 7 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 9054200.0 2926900.0 4349200.0 1778100.0 False True 4440321.285052159 3573051.279545304 1426657.7556310839 1.0 0.8046830511056887 0.32129606486669476 22.08223263769728 -6.955678195737379 0.4925871460368667 1.0103347215602292 0.09505668804960571 0.9995747928347994 0.005882582526826677 0.08128274973978715 0.027123336433056977 0.006998883814581527 0.039868715587302664 1.107444075821225e-07 6.955678195737379 -0.9152780335106234 down SFLHIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFLHIGK 7 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 13985700.0 4155100.0 5081800.0 4748800.0 False True 5691352.757355407 4857269.272734656 3627231.244605995 1.0 0.8534472347469948 0.6373232163334496 22.44034017165804 -6.9655382751320865 0.3486924433657749 1.021202514402796 0.4622897730646462 0.9999238118737899 0.0013002617772506703 0.07777879395592303 0.014218658421991744 0.002976647680736341 0.018592673923619296 1.0825843008754333e-07 6.9655382751320865 -0.5589127413381498 SFLHIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFLHIGK 7 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 7172800.0 3645400.0 1798900.0 1728500.0 False True 3031311.6186020863 1789208.9686463075 2089921.358318985 1.0 0.5902425067969144 0.6894445775531217 21.531510738009654 -9.852205759197656 6.36843763797671 1.0000000176536772 0.6398435421749576 0.9461623614073473 0.040499075796932196 1.0201073791419434e-08 1.7432979303626888e-09 0.0392130638617516 0.01307102050815787 1.405381527439649e-10 9.852205759197656 -0.36015647547871954 SFLHIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFLHIGK 7 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 11116700.0 2926900.0 5278500.0 2911300.0 False True 3788929.747824468 4984746.83482558 2381473.272460586 1.0 1.3156081444074617 0.6285345548642022 21.85335895978973 -6.781818294016437 1.5289132730148274 1.1782830337175823 0.6227905451827249 0.7737327909156809 0.13357227043761388 0.24775810643037546 1.1440644185909246 0.06880369635191104 0.16209420083185658 1.6526531129002626e-07 6.781818294016437 -0.5554924885348573 SFLLDLLNATGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFLLDLLNATGK 12 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;A0A0J9YVQ7 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 0 261460000.0 156380000.0 105080000.0 0.0 False True 151415802.49808428 147038991.98496088 0.0 1.0 0.9710940969111941 0.0 27.173940539032273 -7.046836660677527 1.0552502035625668 1.0135160931045482 3.208029266674771e-19 0.9876607309490955 0.051624501673909626 0.08547280988486572 0.183465733631414 0.04103102620705677 0.07358628856767926 8.977663833636302e-08 7.046836660677527 -1.0135160931045482 down SFLLDLLNATGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFLLDLLNATGK 12 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;A0A0J9YVQ7 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 0 79257000.0 22894000.0 25886000.0 30477000.0 False True 34731871.77559331 21266441.05175886 24453207.591456335 1.0 0.6123033388227339 0.7040567162475829 25.04975682697875 -10.120273433064636 5.896161485293994 1.000002222222463 0.6581800275351496 0.9487311379944899 0.03745815947802418 1.0942272807631543e-06 1.6324969444704905e-07 0.03626894256120877 0.012089568986490997 7.581001227076159e-11 10.120273433064636 -0.34182219468731334 SFLLDLLNATGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFLLDLLNATGK 12 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;A0A0J9YVQ7 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 0 151888000.0 30778000.0 0.0 121110000.0 False True 42157458.34417575 0.0 92506312.33874479 1.0 0.0 2.194304779560435 25.3292845543179 -6.7827863391431125 1.5249249817815747 0.43582882303108106 2.2132644440248894 0.7771741448405405 0.4234195702451544 0.24625641167857046 1.1312171113988434 0.21865377180413936 0.5147620894949803 1.648973441265321e-07 6.7827863391431125 1.7774356209938085 SFLLDLLNATGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFLLDLLNATGK 12 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;A0A0J9YVQ7 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 0 68731000.0 22894000.0 23682000.0 22155000.0 False True 29636734.308207765 22364075.88184892 18123017.329496905 1.0 0.7546066192473604 0.6115052063775398 24.8208831490712 -13.225509342191959 0.06391143595517662 2.387222734464019 1.065808389174495e-09 0.9999538840579865 0.0010894068201543164 9.4944777387385 0.05930044682529259 2.2434964575788756 0.5245889297143222 5.949639582374216e-14 13.225509342191959 -2.3872227333982106 SFLLK(ub)DSETSQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFLLKDSETSQR 12 1 P34897;P34897-3;P34897-2 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial 1 6577220.0 1265400.0 1248400.0 4063420.0 True False 1225230.5696449417 1746892.6303199953 2999088.4020129815 1.0 1.4257664423327485 2.447774709769186 20.224621837231478 -6.9563269948038435 0.48443314733782666 0.9764636168396257 2.9400084267748583 0.9996087856513215 0.012016410504407316 0.08104024788859479 0.026184974263865752 0.014542094284695137 0.08429679035470258 1.1057908836114205e-07 6.9563269948038435 1.9635448099352326 up SFLLK(ub)DSETSQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFLLKDSETSQR 12 1 P34897;P34897-3;P34897-2 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial 1 62826000.0 4076000.0 2614000.0 56136000.0 True False 6183589.995514903 2147511.276724783 45040694.99471716 1.0 0.34729199029729024 7.28390708753106 22.560013233501696 -6.883854862580426 1.0580963303635202 0.5705529287836343 7.813275164563818 0.9766629746044043 0.4777681597261122 0.12426889493466814 0.2521321339673973 0.34653995980999486 0.8468415146812992 1.3066074719722724e-07 6.883854862580426 7.2427222357801835 up SFLLK(ub)DSETSQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFLLKDSETSQR 12 1 P34897;P34897-3;P34897-2 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial 1 6826850.0 1265400.0 2588700.0 2972750.0 True False 1052236.1667249366 2574754.1592832827 3594338.280556988 1.0 2.446935622158999 3.415904522408018 20.005027112665754 -8.219211007721395 0.19999543050900334 1.433108351248682e-16 4.62257691511291 0.9997736392864933 0.014935489420710714 0.08918183410075091 0.04306153319416925 0.39557868583252764 0.4264260613628195 6.036552642157119e-09 8.219211007721395 4.62257691511291 SFLLK(ub)DSETSQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFLLKDSETSQR 12 1 P34897;P34897-3;P34897-2 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial 1 30876500.0 4076000.0 4392100.0 22408400.0 True False 5276462.349971815 4147675.774033807 18330301.12960045 1.0 0.7860713294118289 3.4739755377385313 22.331139555594145 -6.887644378679829 1.0362444643296833 0.8473141715836979 3.6947429409304795 0.9793461928852383 0.17530234767910902 0.12107407711479988 0.2331926482043225 0.12928365401205058 0.31968248900981 1.2952560255858578e-07 6.887644378679829 2.8474287693467817 up SFLSGLYEFPLNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFLSGLYEFPLNK 13 0 Q9UJA5;Q9UJA5-2;Q9UJA5-3;Q9UJA5-4 Q9UJA5 TRMT6 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 0 5495230.0 914130.0 2874700.0 1706400.0 False True 1198433.282447513 2445805.965492836 1529838.0969446152 1.0 2.0408361494249085 1.2765317179945865 20.192718164784896 -10.087464263584408 4.443170028000728 0.9999498841940916 1.6586839332195267 0.49755934893572495 0.3120259777021532 102260588.89249557 7.181807666628732 60776.818182565876 0.1125926763597233 8.175903115248237e-11 10.087464263584408 0.6587340490254351 SFLSGLYEFPLNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFLSGLYEFPLNK 13 0 Q9UJA5;Q9UJA5-2;Q9UJA5-3;Q9UJA5-4 Q9UJA5 TRMT6 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 0 10719300.0 4223300.0 3203700.0 3292300.0 False True 4089233.6532175387 4482954.117074793 2429947.8631171104 1.0 1.0962822125723881 0.5942306234335987 21.96339906816488 -6.857019132308817 1.2006869093853418 1.0518796716567906 0.5712648726900347 0.9499158807081188 0.04868786626895839 0.14990351522438997 0.41235248672869546 0.031662892473516745 0.07368093660075721 1.3898913999098538e-07 6.857019132308817 -0.48061479896675596 SFLSGLYEFPLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFLSGLYEFPLNK 13 0 Q9UJA5;Q9UJA5-2;Q9UJA5-3;Q9UJA5-4 Q9UJA5 TRMT6 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 0 10675730.0 914130.0 3933300.0 5828300.0 False True 1252108.5644343814 3759513.8003162732 4451775.577606366 1.0 3.0025461905650084 3.555422991310166 20.255928226307788 -9.757551384381298 0.3425744894555675 5.9736334275680075e-24 3.6895536118387753 0.9986619405476995 0.040156167805017226 1.1099809408465837 0.14671623811065163 1.3641234469136712 0.16675752996328122 1.7476264764201156e-10 9.757551384381298 3.6895536118387753 SFLSGLYEFPLNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFLSGLYEFPLNK 13 0 Q9UJA5;Q9UJA5-2;Q9UJA5-3;Q9UJA5-4 Q9UJA5 TRMT6 tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 0 8366500.0 4223300.0 1749200.0 2394000.0 False True 3511861.0739129265 1739776.712410983 2894574.3313946454 1.0 0.4954002096878275 0.824228029091567 21.743804343599155 -10.082914786084332 5.365627631323758 1.0000040829907915 0.659814119389436 0.5879743901130896 0.1342433951294623 6.556979509231251e-06 1.1206764244774339e-06 0.12998216823359163 0.04332686947276198 8.262000442784542e-11 10.082914786084332 -0.34018996360135545 SFLSQGQVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFLSQGQVLK 10 0 P48047;H7C068 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 14185300.0 2811400.0 6393400.0 4980500.0 False True 3685772.6256363248 5439529.641278003 4465165.636329499 1.0 1.4758180153174543 1.2114598728288664 21.813535643552488 -10.132802823740679 4.429459469605555 0.9999606734454167 1.3436389439309837 0.6925899390309013 0.10792375995207758 75368252.57043287 3.3629082481515042 38074.16339915929 0.03694517360219843 7.365414225336346e-11 10.132802823740679 0.343678270485567 SFLSQGQVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFLSQGQVLK 10 0 P48047;H7C068 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 14296800.0 6332300.0 2871900.0 5092600.0 False True 6131284.602625775 4018664.6467606514 3758695.2852747943 1.0 0.6554359986877177 0.6130355266276664 22.54775794269817 -13.999999999999998 0.2954966534311538 4.063034488025417 0.6021080692824025 0.9996397662220139 0.003289001832489354 16.300860495711646 0.17251419274237187 30.449210389799717 0.01562611399346722 1.0000000000000041e-14 13.999999999999998 -3.460926418743014 SFLSQGQVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFLSQGQVLK 10 0 P48047;H7C068 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 12543700.0 2811400.0 5339800.0 4392500.0 False True 3850850.555228267 5103869.979642752 3355081.9663771526 1.0 1.3253877049872194 0.8712573802226593 21.87674570507538 -6.714388124460644 1.7795890903489202 1.1991409269494053 0.8721823499586662 0.48586992252258787 0.1370269426977564 0.36634012980750236 2.264163982431705 0.061214500785118295 0.15469020104048922 1.9302425083131895e-07 6.714388124460644 -0.32695857699073916 SFLSQGQVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFLSQGQVLK 10 0 P48047;H7C068 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 10883900.0 6332300.0 2864000.0 1687600.0 False True 5265588.018454488 2848571.06354051 2040469.3574192182 1.0 0.5409787194814757 0.38751025531581934 22.328163218132445 -13.999999999999998 0.153056212499608 3.2306566600266 0.2244565271438481 0.9995563608673647 0.005480794394206405 11.970541439266498 0.12336070673866714 7.935133528895865 0.14742191992456444 1.0000000000000041e-14 13.999999999999998 -3.0062001328827517 SFLSQGQVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFLSQGQVLK 10 0 P48047;H7C068 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 17770900.0 7168200.0 4799200.0 5803500.0 False True 9279376.20634643 4532120.301164142 4747322.548938623 1.0 0.48840786281134885 0.511599319110674 23.145596394692255 -10.212528521620053 5.428048879789038 1.0000265786678078 0.5000035909609666 0.9983890446519101 0.0094678723877665 3.045467024579709e-06 4.4183625282172186e-07 0.009167714262331402 0.0030557426734574974 6.130155319785441e-11 10.212528521620053 -0.5000229877068412 SFLVASVLPGPDGNINSPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFLVASVLPGPDGNINSPTR 20 0 Q7Z3K3-5;Q7Z3K3-7;Q7Z3K3-2;Q7Z3K3-3;Q7Z3K3-6;Q7Z3K3 Q7Z3K3-5 POGZ Pogo transposable element with ZNF domain 0 3146260.0 0.0 2211800.0 934460.0 False True 0.0 1881808.0615288725 837771.0431732673 0.0 SFLVASVLPGPDGNINSPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFLVASVLPGPDGNINSPTR 20 0 Q7Z3K3-5;Q7Z3K3-7;Q7Z3K3-2;Q7Z3K3-3;Q7Z3K3-6;Q7Z3K3 Q7Z3K3-5 POGZ Pogo transposable element with ZNF domain 0 4350600.0 0.0 2006500.0 2344100.0 False True 0.0 1917846.1953918065 1790471.8582549067 0.0 SFLYEIVSNKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFLYEIVSNKR 11 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;A0A2R8YD90 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 4850100.0 0.0 2545600.0 2304500.0 False True 0.0 2165806.4026710824 2066052.4463249303 0.0 SFLYEIVSNKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFLYEIVSNKR 11 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;A0A2R8YD90 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 4345860.0 1757100.0 711160.0 1877600.0 False True 1701321.822287912 995129.896650408 1385800.23320739 1.0 0.5849157305889208 0.8145432657436831 20.6982246365473 -10.115015903970301 5.2453087341032925 1.0000068469611134 0.6997294981660195 0.6951128255973462 0.0937450486713498 7.506360937670715e-06 1.2664054371023669e-06 0.09077032187531665 0.030256084357652854 7.673333889106512e-11 10.115015903970301 -0.30027734879509393 SFLYEIVSNKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFLYEIVSNKR 11 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;A0A2R8YD90 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 3131900.0 0.0 1818100.0 1313800.0 False True 0.0 1737770.330347292 1003507.498560341 0.0 SFLYEIVSNKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFLYEIVSNKR 11 1 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;A0A2R8YD90 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 3824940.0 1757100.0 948640.0 1119200.0 False True 1461106.502728294 943529.4880297033 1353219.5454038812 1.0 0.6457636635439443 0.9261607849099585 20.478629911981578 -9.869911978217198 6.144129807222343 1.0000000243827638 0.785962224226872 0.43722630467591916 0.11447164544894699 3.8152704802502436e-08 7.257835966676595e-09 0.11083670567021366 0.03694556470301941 1.349236314920181e-10 9.869911978217198 -0.2140378001558918 SFMALSQDIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFMALSQDIQK 11 0 Q14444-2;Q14444;G3V153;E9PLA9 Q14444-2 CAPRIN1 Caprin-1 0 12108800.0 4384900.0 1758700.0 5965200.0 False True 4245703.749672906 2460958.0814993423 4402735.167835922 1.0 0.5796349030920817 1.0369859574340565 22.017572277875846 -6.66501385743638 1.9548355118674399 0.7305463040502886 1.0351118503530157 0.25725533364796715 0.17876862201566585 0.4726605299069424 3.477156147719734 0.07374571902457688 0.19833545755923138 2.1626495169644025e-07 6.66501385743638 0.30456554630272703 SFMALSQDIQK(ub)TIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFMALSQDIQKTIK 14 1 Q14444-2;Q14444;G3V153;E9PLA9 Q14444-2 CAPRIN1 Caprin-1 1 12796600.0 2050400.0 5909100.0 4837100.0 True False 2688094.256101847 5027485.313491394 4336603.292739567 1.0 1.8702786563675136 1.6132631074582606 21.358152295397176 -10.297381153194705 6.468184375346216 0.9999788358157162 1.7417708819128872 0.9173966521355877 0.10492615846483434 3.2024417846320184e-05 3.478871238301596e-06 0.1015972050200809 0.033864772026318594 5.042185821013841e-11 10.297381153194705 0.741792046097171 SFMALSQDIQK(ub)TIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFMALSQDIQKTIK 14 1 Q14444-2;Q14444;G3V153;E9PLA9 Q14444-2 CAPRIN1 Caprin-1 1 49371400.0 15566200.0 20044700.0 13760500.0 True False 15072059.50150708 28048653.24172961 10156212.243848685 1.0 1.860970177229262 0.6738436935465355 23.845373229760522 -6.712186597936279 1.7872651201073992 1.528133559570202 0.6764392568186438 0.47543775373267105 0.3626895493894101 0.3707550134581895 2.3099007645917253 0.1614022819615128 0.40897639988341333 1.940052140297002e-07 6.712186597936279 -0.8516943027515581 SFMALSQDIQK(ub)TIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFMALSQDIQKTIK 14 1 Q14444-2;Q14444;G3V153;E9PLA9 Q14444-2 CAPRIN1 Caprin-1 1 13120700.0 2932000.0 7151900.0 3036800.0 True False 4448058.357912102 5875587.566950248 2436575.1489232755 1.0 1.3209331115224445 0.5477839886226207 22.084744285469696 -6.793971665429989 1.4804633325607461 1.1784464664368741 0.5386413134374977 0.8139318607571263 0.13680459537481224 0.22947746488521675 0.9934829304529452 0.0727198719130049 0.16977320633591503 1.6070460977131497e-07 6.793971665429989 -0.6398051529993765 SFMALSQDIQK(ub)TIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFMALSQDIQKTIK 14 1 Q14444-2;Q14444;G3V153;E9PLA9 Q14444-2 CAPRIN1 Caprin-1 1 14928000.0 2050400.0 8112100.0 4765500.0 True False 2808488.289976543 7753680.598872607 3639987.048553287 1.0 2.7608021819230615 1.296066307822736 21.421362356920067 -6.60081540229612 2.187241648327902 2.1835138407916235 1.3008028715218585 0.023012444438840318 0.7609053951275168 0.6383669895805092 5.772683168447701 0.288617372110354 0.8464529970523497 2.5071747060051157e-07 6.60081540229612 -0.882710969269765 SFMALSQDIQK(ub)TIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFMALSQDIQKTIK 14 1 Q14444-2;Q14444;G3V153;E9PLA9 Q14444-2 CAPRIN1 Caprin-1 1 42774000.0 15566200.0 20967500.0 6240300.0 True False 12943984.99958407 20854543.9157771 7545117.878112787 1.0 1.6111378309266597 0.5829053323497544 23.6257785051948 -6.745696919495223 1.6657061646040998 1.3612119602385484 0.5815107167298303 0.6302314287602945 0.2567694230784559 0.3076346757840894 1.6779500380651573 0.12184250756991305 0.29715686435589206 1.795986552307737e-07 6.745696919495223 -0.7797012435087181 SFMDGFTTLK(ub)ENIMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFMDGFTTLKENIMR 15 1 Q13323 Q13323 BIK Bcl-2-interacting killer 1 27933200.0 1682300.0 4301600.0 21949300.0 True False 1628896.307344464 6019251.312547659 16200119.86511448 1.0 3.6952943446477855 9.9454580331912 20.63546333669813 -6.957052686246418 0.4751614998514083 0.8429303053486279 13.056283410319175 0.9996447568611234 0.07062034982227199 0.08077137961124878 0.025153526043205792 0.08727911169476613 0.5156943650563126 1.1039446872080605e-07 6.957052686246418 12.213353104970547 SFMDGFTTLK(ub)ENIMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFMDGFTTLKENIMR 15 1 Q13323 Q13323 BIK Bcl-2-interacting killer 1 51362600.0 2006900.0 39018700.0 10337000.0 True False 3044614.024042905 32055508.13050541 8293887.419131953 1.0 10.528595045995125 2.724117853243875 21.53782791374665 -6.596803283880337 2.2028771210708644 7.421486552761595 2.748692283025322 0.01140161699036868 4.12193329996298 0.6498934960206387 5.955407484912997 1.556004061953989 4.587721077968367 2.5304439156552296e-07 6.596803283880337 -4.672794269736274 SFMDGFTTLK(ub)ENIMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SFMDGFTTLKENIMR 15 1 Q13323 Q13323 BIK Bcl-2-interacting killer 1 25932310.0 2002260.0 5642150.0 18287900.0 True False 1664967.9051577928 5611754.618070915 22111815.336304154 1.0 3.3704881641782016 13.280625571102865 20.66706293670121 -6.943861958186764 0.6226089731924457 0.8917046686268658 16.286776229685405 0.9986271319547313 0.19708778031969834 0.08604839785013618 0.04691426516063694 0.19801240772239806 0.8395287836099796 1.1379889415670606e-07 6.943861958186764 15.395071561058538 SFMDGFTTLK(ub)ENIMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFMDGFTTLKENIMR 15 1 Q13323 Q13323 BIK Bcl-2-interacting killer 1 35708900.0 2006900.0 25694300.0 8007700.0 True False 2597971.6119132615 24264389.617895022 6550380.76594052 1.0 9.339743939705965 2.5213442425248553 21.3089542358391 -6.596227986784977 2.203903025393001 6.622060077961391 2.5420929810681767 0.01006233434822179 3.6080996864918067 0.6515945525890083 5.975074919486785 1.3614334629410396 4.018863991848776 2.53379814123361e-07 6.596227986784977 -4.079967096893215 SFNFYVFPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFNFYVFPK 9 0 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;A0A494C0Q6;A0A494C002 O95453 PARN Poly(A)-specific ribonuclease PARN 0 13221700.0 4709700.0 3490600.0 5021400.0 False True 6174462.308799676 2969816.086252229 4501833.696669996 1.0 0.4809837582164406 0.7291053814117716 22.557882077162624 -10.074284173954775 5.095853992897655 1.0000075724311357 0.605044569812861 0.7716038821961061 0.10129522850095009 8.71474787846439e-06 1.5829048590759427e-06 0.09808056341353227 0.03269289441891548 8.427831150575338e-11 10.074284173954775 -0.39496300261827466 SFNFYVFPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFNFYVFPK 9 0 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;A0A494C0Q6;A0A494C002 O95453 PARN Poly(A)-specific ribonuclease PARN 0 12010100.0 3923800.0 3173800.0 4912500.0 False True 3799241.116779527 4441114.891148349 3625768.8781589787 1.0 1.1689478910759195 0.9543402923667045 21.85727984409193 -6.696801538586914 1.8423829953080744 1.1052367843614177 0.9550175143436516 0.4023960975149352 0.07135749449517899 0.4021959167300576 2.6518815347972198 0.03092628034947995 0.07984658551774954 2.0100111261798028e-07 6.696801538586914 -0.15021927001776614 SFNFYVFPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFNFYVFPK 9 0 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;A0A494C0Q6;A0A494C002 O95453 PARN Poly(A)-specific ribonuclease PARN 0 15038200.0 4709700.0 3176200.0 7152300.0 False True 6451003.3648568615 3035864.9817111692 5463074.046242304 1.0 0.47060353405636934 0.8468564868534249 22.621092138685515 -9.84423882495112 5.630900584233411 1.0000001059550898 0.6587300104532752 0.5231101687988134 0.15360462476712353 2.0441559219435052e-07 4.17194257314278e-08 0.14872708494340556 0.049575679467790235 1.431400534502649e-10 9.84423882495112 -0.34127009550181464 SFNFYVFPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFNFYVFPK 9 0 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;A0A494C0Q6;A0A494C002 O95453 PARN Poly(A)-specific ribonuclease PARN 0 8370500.0 3923800.0 1648100.0 2798600.0 False True 3262813.5538132596 1639221.358177762 3383774.320735618 1.0 0.5023950437688968 1.0370725341572127 21.637685119526207 -11.895366167650131 14.218407934515554 0.904734544945843 0.7927604100667475 0.0 0.2496322011537333 0.0 0.0 0.0 0.07254111394101763 1.2724298021185523e-12 11.895366167650131 -0.11197413487909558 SFNFYVFPKPFNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFNFYVFPKPFNR 13 1 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;A0A494C0Q6;A0A494C002 O95453 PARN Poly(A)-specific ribonuclease PARN 0 59200000.0 14704000.0 16644000.0 27852000.0 False True 19277086.39373856 14160780.077803874 24970142.215249278 1.0 0.7345913064125434 1.2953276083962508 24.200383678281995 -6.778031448157249 1.543895375157241 0.8493322423560643 1.29947031205982 0.7602342025761362 0.11214570149184006 0.2536503413424831 1.1941275366342496 0.057223554804501635 0.13522751225282328 1.6671264881200743e-07 6.778031448157249 0.4501380697037558 SFNFYVFPKPFNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFNFYVFPKPFNR 13 1 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;A0A494C0Q6;A0A494C002 O95453 PARN Poly(A)-specific ribonuclease PARN 0 56990000.0 24069000.0 13552000.0 19369000.0 False True 23304942.769704487 18963384.272746403 14295677.84245525 1.0 0.8137065368552657 0.61341827713214 24.474132634245017 -6.970202313263766 0.25330814813860036 1.0610305208171402 0.3602032832302407 0.9999839164444355 0.0006330434249155268 0.07623712320928167 0.008794989942089758 0.004368890358033327 0.01909370011267364 1.0710202611757413e-07 6.970202313263766 -0.7008272375868996 SFNFYVFPKPFNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFNFYVFPKPFNR 13 1 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;A0A494C0Q6;A0A494C002 O95453 PARN Poly(A)-specific ribonuclease PARN 0 86033000.0 25383000.0 19384000.0 41266000.0 False True 38507866.74586725 15924773.752116749 33109757.012469683 1.0 0.41354598677751553 0.8598180011107235 25.198649867315172 -9.869846360671298 6.469578575530707 1.0000000177283843 0.6366819939441066 0.4691347318083945 0.18218978693351534 4.687400984903909e-08 8.126131289448828e-09 0.17640451317510855 0.05880150088686444 1.3494401864131856e-10 9.869846360671298 -0.3633180237842777 SFNFYVFPKPFNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFNFYVFPKPFNR 13 1 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;A0A494C0Q6;A0A494C002 O95453 PARN Poly(A)-specific ribonuclease PARN 0 58258000.0 14704000.0 15781000.0 27773000.0 False True 20140466.16065893 15083743.239211624 21213589.402889583 1.0 0.748927215432343 1.0532819465880499 24.263593739804886 -6.687565896153737 1.8748754618070083 0.8422380351342788 1.0522059348402082 0.35914943239405994 0.10623879872842759 0.4219176092922815 2.8734946646651114 0.04536128314012117 0.11849590255800481 2.0532134656593554e-07 6.687565896153737 0.20996789970592944 SFNFYVFPKPFNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFNFYVFPKPFNR 13 1 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;A0A494C0Q6;A0A494C002 O95453 PARN Poly(A)-specific ribonuclease PARN 0 48637000.0 24069000.0 12205000.0 12363000.0 False True 20014439.93749207 12139249.242497168 14948046.13994653 1.0 0.6065245532930106 0.7468630741920032 24.254537909679293 -10.27665920235854 5.976796235627642 1.0000153586516023 0.6766938153143431 0.8761826068432603 0.0572929612432441 1.1725870536018206e-05 1.4191463234949227e-06 0.05547630403569613 0.01849122372916548 5.2886009373677415e-11 10.27665920235854 -0.32332154333725915 SFNFYVFPKPFNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFNFYVFPKPFNR 13 1 O95453;A0A494C1N1;A0A494C0Q2;O95453-2;A0A494C1K5;A0A494C0P9;A0A494C0W0;A0A494BZW7;A0A494BZU6;A0A494C156;A0A494C0Q6;A0A494C002 O95453 PARN Poly(A)-specific ribonuclease PARN 0 101005000.0 25383000.0 42258000.0 33364000.0 False True 32858793.87373275 39906305.15223256 27292094.343549304 1.0 1.2144786964969392 0.8305872226602494 24.96977618940762 -6.7550703956831635 1.630844058545786 1.1253421107863018 0.8295081690384308 0.670576316439287 0.09015824838997606 0.2912890431671357 1.5256592376397944 0.043642297608132485 0.10540375380149805 1.7576386916076443e-07 6.7550703956831635 -0.2958339417478709 SFNLIIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFNLIIAK 8 0 A0A1B0GV75;A0A1B0GTB8;A0A1B0GWC0;A0A1B0GVF3;P23786 A0A1B0GV75 CPT2 Carnitine O-palmitoyltransferase 2, mitochondrial 0 8525700.0 2452300.0 2696500.0 3376900.0 False True 3214989.04810698 2294192.710874673 3027490.7815121096 1.0 0.7135926986207055 0.941679967244283 21.61638239233038 -9.908226548947527 5.890283941623945 1.000000063913008 0.8276363334952047 0.43227838817061215 0.09311623749255236 7.816905712128688e-08 1.4483348531054938e-08 0.09015944218255795 0.030053136422453327 1.235302871786053e-10 9.908226548947527 -0.17236373041780328 SFNLIIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFNLIIAK 8 0 A0A1B0GV75;A0A1B0GTB8;A0A1B0GWC0;A0A1B0GVF3;P23786 A0A1B0GV75 CPT2 Carnitine O-palmitoyltransferase 2, mitochondrial 0 7448700.0 2618300.0 976500.0 3853900.0 False True 2535183.499684961 1366421.5423802284 2844447.975478251 1.0 0.5389832895922639 1.1219889904741496 21.273658744365168 -6.695897800772035 1.8451952917555954 0.7125934213504507 1.1201461820811776 0.3983116951097394 0.19474935995167506 0.4040966810939781 2.671797281076375 0.0842887284599472 0.21789725859547862 2.0141981800847344e-07 6.695897800772035 0.4075527607307269 SFNLIIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFNLIIAK 8 0 A0A1B0GV75;A0A1B0GTB8;A0A1B0GWC0;A0A1B0GVF3;P23786 A0A1B0GV75 CPT2 Carnitine O-palmitoyltransferase 2, mitochondrial 0 13083100.0 2438300.0 4658900.0 5985900.0 False True 3699079.363607463 3827482.8948481586 4802784.241286828 1.0 1.0347122942275757 1.2983728569162127 21.818734823085524 -6.931073468060518 0.7379183121791243 0.9961461621338493 1.3540127598199696 0.9967452565175161 0.007600724420206738 0.09208387165054252 0.0749748665696954 0.006969426752545398 0.023717391442182018 1.1719970861781697e-07 6.931073468060518 0.3578665976861203 SFNLIIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFNLIIAK 8 0 A0A1B0GV75;A0A1B0GTB8;A0A1B0GWC0;A0A1B0GVF3;P23786 A0A1B0GV75 CPT2 Carnitine O-palmitoyltransferase 2, mitochondrial 0 9060200.0 2452300.0 2231900.0 4376000.0 False True 3358981.5809156587 2133287.2780936807 3342478.926548982 1.0 0.6350994272234581 0.9950870065913913 21.67959245385327 -10.87344596471102 10.180842946978556 1.0095175701267805 0.8150932169074249 0.2602338753016207 0.1469643138651829 0.03180372916900273 0.0003953390272962076 0.1425449359690611 0.04743252834055441 1.3383017174340706e-11 10.87344596471102 -0.19442435321935558 SFNLIIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFNLIIAK 8 0 A0A1B0GV75;A0A1B0GTB8;A0A1B0GWC0;A0A1B0GVF3;P23786 A0A1B0GV75 CPT2 Carnitine O-palmitoyltransferase 2, mitochondrial 0 6721200.0 2618300.0 2240700.0 1862200.0 False True 2177232.4603571207 2228628.9043558734 2251577.410160031 1.0 1.0236063190011058 1.0341465374766257 21.054064019799444 -13.999999999999957 0.10909858668319172 0.8859125130895945 1.0537355271488489 0.9997474797705844 0.00022679118287946345 12.018254908351137 0.1000832973927564 0.3025362556551518 0.017403565981251343 1.0000000000000981e-14 13.999999999999957 0.16782301405925437 SFNLIIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFNLIIAK 8 0 A0A1B0GV75;A0A1B0GTB8;A0A1B0GWC0;A0A1B0GVF3;P23786 A0A1B0GV75 CPT2 Carnitine O-palmitoyltransferase 2, mitochondrial 0 10142000.0 2438300.0 4080300.0 3623400.0 False True 3156427.416078583 3853227.7181280362 2963978.379223611 1.0 1.2207560036071192 0.9390294749454234 21.589861145177974 -6.6977141280516825 1.8391472579809511 1.1373892294503876 0.9399066168559315 0.4066467557508079 0.0932238015113773 0.4003140120713751 2.630866913472831 0.04046418165690379 0.10435296649347481 2.0057918943758554e-07 6.6977141280516825 -0.1974826125944561 SFNLPMLMLGGGGYTIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFNLPMLMLGGGGYTIR 17 0 Q13547 Q13547 HDAC1 Histone deacetylase 1 0 3147200.0 3147200.0 0.0 0.0 False True 3047293.8586901804 0.0 0.0 1.0 0.0 0.0 21.539097198995158 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 SFNLPMLMLGGGGYTIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFNLPMLMLGGGGYTIR 17 0 Q13547 Q13547 HDAC1 Histone deacetylase 1 0 6527300.0 3147200.0 1387600.0 1992500.0 False True 2617036.244599901 1380124.7233829633 2409122.537720899 1.0 0.5273617154637307 0.9205537533887734 21.319502474429434 -10.03672626936654 7.189801545057804 1.0000000327513063 0.7239577344262523 0.39656311951401335 0.16051997730690137 8.422397419276134e-08 1.1274209018076708e-08 0.15542281823860207 0.05180759990360175 9.18911593017178e-11 10.03672626936654 -0.276042298325054 SFPDFPTPGVVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFPDFPTPGVVFR 13 0 P07741-2;P07741;H3BQB1;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 0 34114770.0 8964770.0 12708000.0 12442000.0 False True 11752900.284956168 10812015.935396012 11154621.192091472 1.0 0.9199444965286996 0.9490951953680319 23.48651348146192 -10.02652039548394 5.995544042652743 1.0000000954047525 0.9345198461408681 0.8705936942527951 0.01190072296700323 1.5172734074798516e-08 2.4629195172360636e-09 0.011522842291694518 0.0038409418215831943 9.407616486333179e-11 10.02652039548394 -0.0654802492638844 SFPDFPTPGVVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFPDFPTPGVVFR 13 0 P07741-2;P07741;H3BQB1;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 0 25879300.0 8679600.0 5562700.0 11637000.0 False True 8404070.84897284 7783915.119097283 8588920.597483173 1.0 0.9262076985046653 1.0219952629900693 23.00265689376147 -6.700958758611681 1.8276261680900652 0.9542209731126418 1.02171398674883 0.42208182731416377 0.031143181668893773 0.39351378622001326 2.5561273160369105 0.013591491478751456 0.034910133003135904 1.9908623858985048e-07 6.700958758611681 0.06749301363618831 SFPDFPTPGVVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFPDFPTPGVVFR 13 0 P07741-2;P07741;H3BQB1;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 0 34849770.0 8964770.0 10201000.0 15684000.0 False True 12279287.732799932 9750286.08980405 11979762.222119344 1.0 0.7940432948532905 0.9756072569355544 23.54972354298481 -10.252227302837229 6.639236541551948 1.000001249445636 0.8848252759262611 0.3491827850610899 0.07412317712992993 1.3708166846743884e-06 1.5439853189868576e-07 0.07177023565307282 0.023923152549350082 5.594647099069544e-11 10.252227302837229 -0.11517597351937492 SFPDFPTPGVVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFPDFPTPGVVFR 13 0 P07741-2;P07741;H3BQB1;H3BQF1;H3BQZ9;H3BSW3 P07741-2 APRT Adenine phosphoribosyltransferase 0 22517300.0 8679600.0 6222500.0 7615200.0 False True 7217471.971476021 6188978.157430458 9207503.11129346 1.0 0.8574994377379993 1.2757241244139481 22.783062169195745 -6.8147482365428 1.3942673226184026 0.9227569779784278 1.2838766739731367 0.87188313644696 0.06213845273479125 0.20041752914104383 0.7668950697087645 0.03503200089924254 0.08088448463358357 1.5319753007880247e-07 6.8147482365428 0.36111969599470883 SFPKDDPSKPVHLTAFLGYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFPKDDPSKPVHLTAFLGYK 20 2 P39023;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 52830000.0 19460000.0 13286000.0 20084000.0 False True 25512248.450908072 11303780.58842238 18005900.33933171 1.0 0.4430726915416206 0.705774733025964 24.604686716661433 -10.429485770631757 6.10679211852676 1.0001396257832942 0.5744237122837981 0.777737435883464 0.10724765933735031 0.0002039432271014989 1.9053017330834944e-05 0.103875764977133 0.03461403321110697 3.719754084877814e-11 10.429485770631757 -0.4257159134994961 SFPKDDPSKPVHLTAFLGYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFPKDDPSKPVHLTAFLGYK 20 2 P39023;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 35096000.0 10833000.0 4674000.0 19589000.0 False True 10489112.344684402 6540352.574588008 14458053.242596708 1.0 0.6235372793868951 1.3783867278267505 23.322389257273787 -6.771091961909353 1.5701382191756277 0.7843722032444329 1.382822550753448 0.7347648311992746 0.15870870254174352 0.26466884114115036 1.2878545707818625 0.0796637509281123 0.18945395505222734 1.6939790621948267e-07 6.771091961909353 0.598450347509015 SFPKDDPSKPVHLTAFLGYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFPKDDPSKPVHLTAFLGYK 20 2 P39023;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 199806000.0 40852000.0 73977000.0 84977000.0 False True 61975470.68125002 60775226.36506093 68181258.70325783 1.0 0.9806335586806247 1.1001329712189714 25.88519398731138 -6.8653592585441725 1.1584404870254768 0.9893023807038256 1.106538701139951 0.9598237115547056 0.010496676974896927 0.14137783727331577 0.3575376429682357 0.0070504446578917935 0.01656945449408038 1.3634547882926752e-07 6.8653592585441725 0.11723632043612542 SFPKDDPSKPVHLTAFLGYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFPKDDPSKPVHLTAFLGYK 20 2 P39023;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 49944000.0 19460000.0 15067000.0 15417000.0 False True 26654887.886726238 14401290.120093865 11775822.123081729 1.0 0.5402870265781724 0.441788469459139 24.667896778184325 -13.999999999999998 0.21651372648944153 3.732463521734676 0.38730849736970513 0.9994946485040751 0.005468791853298627 12.907097742095207 0.14743450345482983 15.05182967416332 0.05579271282501117 1.0000000000000041e-14 13.999999999999998 -3.345155024364971 SFPKDDPSKPVHLTAFLGYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFPKDDPSKPVHLTAFLGYK 20 2 P39023;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 22958100.0 10833000.0 6395600.0 5729500.0 False True 9008119.483271083 6361145.6333727995 6927511.959785136 1.0 0.7061568893692007 0.7690297595019884 23.102794532708064 -10.820843210150295 7.199541330362042 1.0134625759389193 0.7375933244355946 0.9587208931989826 0.025667741748267026 0.005555021869947106 0.00013823362225253132 0.024890668721372244 0.008284228027149256 1.5106254246986624e-11 10.820843210150295 -0.27586925150332475 SFPKDDPSKPVHLTAFLGYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFPKDDPSKPVHLTAFLGYK 20 2 P39023;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 205034000.0 40852000.0 90011000.0 74171000.0 False True 52883719.31330933 85001808.72397186 60672639.0587278 1.0 1.6073341630980809 1.147283887112271 25.656320309403828 -10.065044961915012 4.965968103926963 0.9999914150000889 1.3773090251076487 0.47281174614762533 0.18781473870719942 130282828.27147295 4.133761534629672 12789.328092198704 0.06429398063737175 8.609046192904534e-11 10.065044961915012 0.3773176101075598 SFQK(ub)IQVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFQKIQVR 8 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 1 25131300.0 10345300.0 10456400.0 4329600.0 True False 13562788.484027702 8896345.878727976 3881614.5244558174 1.0 0.655937817595903 0.28619590499601344 23.693150488592604 -7.351920589639043 0.3137181238186081 1.0710198051047866 6.200241305767952e-12 0.9997885369928872 0.004238516427808982 0.11056637682280886 0.025026919795118868 0.015036202050688431 0.05363756233773519 4.447125753354504e-08 7.351920589639043 -1.0710198050985864 down SFQK(ub)IQVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFQKIQVR 8 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 1 34373900.0 12626800.0 12221600.0 9525500.0 True False 12225969.145560864 17101748.61480203 7030485.791125379 1.0 1.3988051508384114 0.5750452751369884 23.54344549553028 -6.775043815334342 1.5549551874106189 1.2272669324719776 0.5694804547639302 0.7495366885370672 0.1683332835264013 0.25835359993711465 1.2333959265376464 0.08529300335051958 0.20212416995487975 1.6786346545870055e-07 6.775043815334342 -0.6577864777080474 SFQK(ub)IQVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFQKIQVR 8 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 1 35716900.0 12677400.0 2743100.0 20296400.0 True False 19232542.64208554 2253572.3730618777 16284807.643771876 1.0 0.11717495783061498 0.8467319140703062 24.19704617128017 -10.874987402792442 9.970032923842174 1.0293757566074846 0.4819534359669183 0.4020182982496868 0.2978403801808733 0.1412781269526424 0.0017714601744377053 0.20949460330841743 0.09612756935571735 1.3335601130367826e-11 10.874987402792442 -0.5474223206405663 SFQK(ub)IQVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFQKIQVR 8 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 1 27183200.0 10345300.0 10584100.0 6253800.0 True False 14170236.981220389 10116459.465061773 4776781.241053935 1.0 0.7139230965910429 0.33709960160754787 23.756360550115495 -7.002812148889412 0.32123267077988804 1.0520582397072744 1.873317237637229e-10 0.9999529895645877 0.0018613151522414246 0.07361971323655983 0.012243270836358915 0.005690977685913164 0.031758402364602 9.935457068978784e-08 7.002812148889412 -1.0520582395199427 down SFQK(ub)IQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFQKIQVR 8 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 1 48402200.0 12626800.0 30883000.0 4892400.0 True False 10499743.662085034 30716627.14920443 5915378.220098233 1.0 2.925464481587614 0.5633831082428121 23.323850770964555 -6.689965643729977 1.8665239548382817 2.2071885406619765 0.5715494033296741 0.37025588285217237 0.8143426032133099 0.416750967477014 2.814996573759334 0.34902708080740913 0.908934815323308 2.0418994693439674e-07 6.689965643729977 -1.6356391373323023 SFQK(ub)IQVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFQKIQVR 8 1 P62081;B5MCP9 P62081 RPS7 40S ribosomal protein S7 1 37503000.0 12677400.0 8964200.0 15861400.0 True False 16411144.208913814 8465334.389834888 12974787.9517076 1.0 0.5158284079446995 0.7906083687120526 23.96817249337262 -10.174561546178602 5.524849859568982 1.0000095418488992 0.6532183883283382 0.6798605979159338 0.11217844923713631 1.3184866306281532e-05 1.9699095962503944e-06 0.1086193026147767 0.0362054388082137 6.690190030898313e-11 10.174561546178602 -0.346791153520561 SFSEFGK(ub)LER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFSEFGKLER 10 1 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 42941300.0 10425500.0 18852700.0 13663100.0 True False 13667931.460685614 16039950.647249022 12249373.477709768 1.0 1.173546318503738 0.896212679507782 23.70429158255983 -6.737507164665333 1.6957222542985715 1.1035558480827405 0.8961336884259676 0.593740296691394 0.07292237148154128 0.3223466339245085 1.8189672372703583 0.03403314327785357 0.08374715533314628 1.8301759131895082e-07 6.737507164665333 -0.2074221596567729 SFSEFGK(ub)LER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFSEFGKLER 10 1 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 32868400.0 11812000.0 16510100.0 4546300.0 True False 11437034.525561912 23102669.029034115 3355487.6439235015 1.0 2.0199876967582258 0.29338790893950223 23.447209692737946 -6.746603912938502 1.6622573583961457 1.6021731960321026 0.2907741573140725 0.63437965247553 0.42855113114404886 0.30596026093432277 1.6621978732493774 0.20375088056519539 0.49645895755610725 1.792239674769925e-07 6.746603912938502 -1.31139903871803 SFSEFGK(ub)LER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFSEFGKLER 10 1 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 67493900.0 23904000.0 9910900.0 33679000.0 True False 36264115.61648392 8142222.460784866 27022330.887969937 1.0 0.22452560395775387 0.7451534506934697 25.11203933012512 -10.200188718544027 6.232106712550477 1.0000053386700527 0.48483952732561064 0.5662501629954055 0.21254542839774215 1.5766131344142906e-05 2.023414004877904e-06 0.20579835926399323 0.06859874204141408 6.306832275180773e-11 10.200188718544027 -0.5151658113444421 SFSEFGK(ub)LER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFSEFGKLER 10 1 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 32872200.0 10425500.0 10090100.0 12356600.0 True False 14280089.088543905 9644286.018501306 9438225.57216527 1.0 0.6753659559616026 0.6609360427405887 23.76750164408272 SFSEFGK(ub)LER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFSEFGKLER 10 1 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 34959500.0 11812000.0 16520600.0 6626900.0 True False 9822201.360324755 16431600.248717653 8012554.150676344 1.0 1.672904030973192 0.815759508152806 23.227614968172222 -6.697340975350984 1.8405415061311003 1.4189283998594528 0.8184445093596365 0.40494159666141605 0.28418085136185717 0.40104614291253754 2.639423965403289 0.12327134103358396 0.31804374525701484 2.007516043157267e-07 6.697340975350984 -0.6004838904998163 SFSEFGK(ub)LER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFSEFGKLER 10 1 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 57355600.0 23904000.0 13191000.0 20260600.0 True False 30944199.218284212 12456909.25417908 16573378.691311434 1.0 0.40256040126637305 0.5355891931279517 24.88316565221757 -9.950177370733941 7.062201857780911 1.0000000204632253 0.46907479719770734 0.955031977229358 0.0543087768599662 1.748227574569778e-08 2.551899229420779e-09 0.05258424943357753 0.01752808236096145 1.1215603029531894e-10 9.950177370733941 -0.5309252232655179 SFSHSFSALAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFSHSFSALAK 11 0 Q09161 Q09161 NCBP1 Nuclear cap-binding protein subunit 1 0 9831900.0 2572600.0 2662600.0 4596700.0 False True 3372703.513093839 2265350.4587335098 4121077.5786599303 1.0 0.6716719835997279 1.2218914478135063 21.68547406912418 -6.745079323902019 1.6681261528635982 0.8058046736540893 1.222583466296762 0.6275174818790388 0.13794472748423783 0.3086988494981493 1.6884647130090935 0.06537089103534381 0.15952706330727096 1.7985423812986982e-07 6.745079323902019 0.4167787926426728 SFSHSFSALAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFSHSFSALAK 11 0 Q09161 Q09161 NCBP1 Nuclear cap-binding protein subunit 1 0 5771100.0 2572600.0 1089700.0 2108800.0 False True 3523759.7419009213 1041553.4508439826 1610744.8720992892 1.0 0.29558015504261026 0.4571097322402462 21.74868413064707 -10.350997298452425 8.70833516954644 1.0000013906293514 0.37634494364939186 0.9520975284579527 0.06594417375028547 1.7804571844234674e-06 1.3263790737492048e-07 0.06385031339359203 0.02128339055952199 4.4565902063005966e-11 10.350997298452425 -0.6236564469799596 SFSHSFSALAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFSHSFSALAK 11 0 Q09161 Q09161 NCBP1 Nuclear cap-binding protein subunit 1 0 2909100.0 1555800.0 1353300.0 0.0 False True 1293716.6336262482 1346009.5042909824 0.0 1.0 1.0404206526418067 0.0 20.303090223725356 -6.995020853308438 1.1294855578971732 1.0355796328224265 1.6945043305669277e-19 0.9824197716420723 0.0638044853946016 0.0931263139325882 0.23291378392363024 0.04753120588484814 0.08744209992836353 1.0115308829038077e-07 6.995020853308438 -1.0355796328224265 down SFSHSFSALAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFSHSFSALAK 11 0 Q09161 Q09161 NCBP1 Nuclear cap-binding protein subunit 1 0 6039200.0 1769700.0 1615100.0 2654400.0 False True 2290911.536002243 1525218.2652129962 2171326.436443987 1.0 0.665769167095199 0.9478002106676986 21.12749031909073 -10.065998013469923 6.86172884573976 1.0000000753655165 0.806784690138426 0.3849140646774608 0.11513869139621279 1.3276897229331308e-07 1.8036410170167955e-08 0.11148260259258434 0.03716085285680385 8.590174507749844e-11 10.065998013469923 -0.19321538522709047 SFSK(ub)EVEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFSKEVEER 9 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 1898100.0 516510.0 675700.0 705890.0 True False 500113.67277327925 945510.5337289494 520996.232753922 1.0 1.8905912499568587 1.041755627005442 18.931896522338846 -10.456702361400279 4.673154281572541 0.9986521744828835 1.466173438481311 0.2868088447026399 0.34653569195537526 0.004879272652818392 0.0005672609832547247 0.3364302808787411 0.11184391365071335 3.493796766872491e-11 10.456702361400279 0.4675212639984275 SFSLK(ub)NVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFSLKNVK 8 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 1 11741900.0 3469200.0 5397100.0 2875600.0 True False 4548154.795780593 4591873.717731032 2578060.49670296 1.0 1.0096124525029355 0.5668365771311642 22.116849926303804 -6.901937974301045 0.9489266535008327 1.0174429513866128 0.518485012698232 0.9875062772518769 0.023081398200143363 0.10999307954034232 0.16948025035623127 0.01817409994803157 0.04776311576351385 1.2533201606555535e-07 6.901937974301045 -0.4989579386883808 SFSLK(ub)NVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFSLKNVK 8 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 1 10775000.0 3009800.0 3032100.0 4733100.0 True False 2914255.546481225 4242833.342192611 3493359.1200436167 1.0 1.4558892569718387 1.1987140675640549 21.474695959930585 -10.214351540989021 4.487333700683436 0.9999051654908137 1.3273016622697473 0.6835060847278216 0.10499133145311268 0.00010255346443764385 1.7955182526049e-05 0.10168762936017829 0.03388580651382934 6.104476961206605e-11 10.214351540989021 0.3273964967789337 SFSLK(ub)NVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFSLKNVK 8 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 1 28056500.0 2870100.0 4488400.0 20698000.0 True False 4354151.532415931 3687409.9519707356 16607031.227744317 1.0 0.8468722148318872 3.8140682757840976 22.053960186143094 -6.8947337544685805 0.993939697088066 0.8581860990724999 4.094278530541279 0.9837598366600258 0.17383543686987193 0.11538700541284944 0.20007559484048407 0.13236016662433175 0.3361319247104185 1.2742840452522184e-07 6.8947337544685805 3.2360924314687796 up SFSLK(ub)NVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFSLKNVK 8 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 1 10675700.0 3469200.0 3319500.0 3887000.0 True False 4751856.991604867 3172833.51388144 2968970.655277854 1.0 0.6677039143827145 0.6248021900749856 22.180059987826695 -13.999999999999998 0.28859624980817916 3.840861486941983 0.612945093937601 0.9996243208226128 0.003249949515156112 15.882851243129808 0.1703310271770813 26.766425346570895 0.016306352305043702 1.0000000000000041e-14 13.999999999999998 -3.227916393004382 SFSLK(ub)NVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFSLKNVK 8 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 1 12530900.0 3009800.0 6491500.0 3029600.0 True False 2502782.056747836 6456529.001038131 3663075.3527122876 1.0 2.579740806288132 1.4636014122109215 21.25510123536486 -10.41834635097545 5.719547279075086 0.9995185894950199 2.0216711092495285 0.5276741406480059 0.45566199955139924 0.0027983933927129096 0.0002845846333120212 0.44138280526650736 0.14706427798017746 3.816397907216447e-11 10.41834635097545 1.0221525197545085 SFSLK(ub)NVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFSLKNVK 8 1 O00148;O00148-2;O00148-3;K7EQN7;K7EPJ3;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 1 23553300.0 2870100.0 5914200.0 14769000.0 True False 3715401.0281290766 5585069.57100038 12081193.542737063 1.0 1.5032211943518765 3.251652634876041 21.825086508235543 -6.948111900768552 0.5792006910711632 0.9790371201936886 3.862198360573663 0.9990446682845647 0.02982514772734933 0.08425287217656961 0.03916914189237731 0.03127604667076987 0.14602483454875637 1.1269070587185676e-07 6.948111900768552 2.8831612403799745 SFSLLQEAIIPYIPTLITQLTQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFSLLQEAIIPYIPTLITQLTQK 23 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 1754000000.0 1021500000.0 360890000.0 371610000.0 False True 1549690181.653208 296486359.8535605 298161120.6175507 1.0 0.1913197640171335 0.19240047084732295 30.529332670731197 -9.92043295579322 6.022168304070119 1.0000002547722393 0.19186011743198242 0.9999986585399037 0.0004411967168153941 1.509514542479551e-09 2.7059849244847087e-10 0.00042718701743390966 0.00014239562792073724 1.2010664733298507e-10 9.92043295579322 -0.8081401373402569 SFTETMSSLSPGKPWQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFTETMSSLSPGKPWQTK 18 1 Q9HB07;F8VQQ3 Q9HB07 C12orf10 UPF0160 protein MYG1, mitochondrial 0 8520300.0 1865500.0 2890400.0 3764400.0 False True 2445688.5655276985 2459163.5866909586 3374895.998674584 1.0 1.0055097044460986 1.379936941376832 21.22180927180974 -6.910104430565348 0.8950340941950967 0.9884443806989438 1.4284316146679696 0.990960213092497 0.01690669136797715 0.10435008733589773 0.13839881254004935 0.013848723873097636 0.03825593322105505 1.2299729756250814e-07 6.910104430565348 0.43998723396902584 SFTETMSSLSPGKPWQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFTETMSSLSPGKPWQTK 18 1 Q9HB07;F8VQQ3 Q9HB07 C12orf10 UPF0160 protein MYG1, mitochondrial 0 6286000.0 1865500.0 2281200.0 2139300.0 False True 2555225.763241922 2180409.0410803827 1634041.4002665076 1.0 0.8533136572300392 0.6394900301072931 21.28501933333263 -6.965728420618939 0.34532408439557527 1.0218074953358327 0.4638324941978374 0.9999273798670212 0.0012614252761920187 0.07771465330092915 0.013993311971152302 0.0029718410232126343 0.018437171425838065 1.082110420890384e-07 6.965728420618939 -0.5579750011379954 SFTLTITVFTNPTQVATYHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFTLTITVFTNPTQVATYHR 20 0 Q13761;Q13761-2 Q13761 RUNX3 Runt-related transcription factor 3 0 44552000.0 10142000.0 16873000.0 17537000.0 False True 15386155.479517225 13861881.320649285 14070804.26325984 1.0 0.9009320969817882 0.9145107289466532 23.87512945640252 -10.39108738314342 5.833761459004346 1.0000258731176115 0.9077214129713332 0.984020034480984 0.0055434532864944985 1.8659636780929699e-06 1.9476373549481126e-07 0.005368929835739736 0.0017891418549225962 4.063615580988556e-11 10.39108738314342 -0.09230446014627824 SFTLTITVFTNPTQVATYHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFTLTITVFTNPTQVATYHR 20 0 Q13761;Q13761-2 Q13761 RUNX3 Runt-related transcription factor 3 0 26687300.0 10142000.0 6642500.0 9902800.0 False True 13129018.928708097 6272839.035773226 8100592.011308581 1.0 0.47778429369592484 0.6169990351370209 23.646255778494968 -10.370691053794838 8.818224349729622 1.00000127742401 0.5473916644165168 0.9337455337434587 0.05683418020069618 1.4273267396826465e-06 1.0187064203950503e-07 0.055029613706752314 0.0183431527843873 4.2590128088711374e-11 10.370691053794838 -0.45260961300749314 SFTPVFLGSALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFTPVFLGSALK 12 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 16133900.0 4153700.0 5439500.0 6540700.0 False True 5445540.924488022 4627947.803004926 5863931.106824678 1.0 0.8498600721543629 1.0768317028810122 22.376643933292197 -6.7283329184379 1.7292934155249626 0.909478601118344 1.0766562248323528 0.5515100606361272 0.06312404619683294 0.33938067353062495 1.9875101408264524 0.02893608063203878 0.07193926143330498 1.8692486753830027e-07 6.7283329184379 0.1671776237140088 SFTPVFLGSALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFTPVFLGSALK 12 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 14069700.0 6528400.0 1919300.0 5622000.0 False True 6321159.515465495 2685686.4990172777 4149429.54361523 1.0 0.4248724450706259 0.6564348729791013 22.59175779129868 -10.263611278306856 5.6107226422483505 1.0000339209015925 0.5406536590248585 0.839914495833545 0.094534965329334 4.011557086151027e-05 5.2650399054283876e-06 0.0915398287362881 0.030511028862895088 5.4499023616417207e-11 10.263611278306856 -0.459380261876734 SFTPVFLGSALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFTPVFLGSALK 12 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 20696600.0 5700700.0 10183000.0 4812900.0 False True 8648378.676995056 8365764.089857867 3861628.2054309887 1.0 0.9673216682926995 0.44651469942025485 23.04399826347239 -6.91970269383628 0.8269314601229213 1.0116150034151454 0.36310230126449455 0.9940978410925747 0.01948020672807422 0.09834716642768307 0.10652409997935477 0.016757784073432667 0.0500555490151507 1.2030877538551895e-07 6.91970269383628 -0.6485127021506509 down SFTPVFLGSALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFTPVFLGSALK 12 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 16888700.0 4153700.0 6096600.0 6638400.0 False True 5689435.139521831 5827232.053239812 5070546.642139577 1.0 1.0242197881404378 0.8912214513031134 22.43985399481509 -6.859741710579986 1.187028015018585 1.0131318775395766 0.8848123862717896 0.9533258450675617 0.012495607355458875 0.1470697953505241 0.39391472639180247 0.00821119669194699 0.019161994798074046 1.3812054693607172e-07 6.859741710579986 -0.12831949126778697 SFTPVFLGSALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFTPVFLGSALK 12 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 12521100.0 6528400.0 2896400.0 3096300.0 False True 5428653.857157481 2880796.5183096114 3743722.0143263373 1.0 0.5306649851162248 0.689622531263506 22.372163066732956 -10.45068609901619 6.352301674236494 1.0001263272025442 0.6101437581898655 0.8891377627889775 0.0648941464709582 0.0001161380641895176 1.0042978723422883e-05 0.06285363125062945 0.020944495712363828 3.5425329708989104e-11 10.45068609901619 -0.3899825690126787 SFTPVFLGSALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFTPVFLGSALK 12 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 15164100.0 5700700.0 5996900.0 3466500.0 False True 7379668.527596751 5663167.243301225 2835632.5692936582 1.0 0.7674013029343313 0.384249314002333 22.81512458556484 -6.963654184898899 0.38044312094638655 1.026188068540991 0.11190377027200045 0.9998826587664725 0.0027500352760719197 0.07842066201046222 0.01648878675496266 0.004984098277701852 0.032369129490075164 1.0872910548446457e-07 6.963654184898899 -0.9142842982689905 down SFTTTIHK(ub)VNSMVAYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFTTTIHKVNSMVAYK 16 1 Q13257 Q13257 MAD2L1 Mitotic spindle assembly checkpoint protein MAD2A 1 10593800.0 1953600.0 2409300.0 6230900.0 True False 1891584.0373465738 3371346.054333523 4598840.36700678 1.0 1.7822872194791253 2.4312112368308094 20.85116344170403 -6.973271723261465 0.16196672582260818 0.36067266623281813 3.8700745191437362 0.9999979554699258 0.0008366467040340577 0.07525462129246833 0.005009771765906521 0.029477760935872375 0.07731393579360703 1.0634774284319555e-07 6.973271723261465 3.5094018529109183 SFVLNLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFVLNLGK 8 0 P09382 P09382 LGALS1 Galectin-1 0 479340000.0 118820000.0 131790000.0 228730000.0 False True 155774170.65451685 112127445.7133964 205063213.73308823 1.0 0.7198076885421385 1.3164134520599495 27.214880795079484 -6.779019531522851 1.5399247273234211 0.8411446910939496 1.3209752682992775 0.7638226273256461 0.11843978125556885 0.2521036007587488 1.1808029449888264 0.06058517794619096 0.14305924733181474 1.6633378434062466e-07 6.779019531522851 0.47983057720532785 SFVLNLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFVLNLGK 8 0 P09382 P09382 LGALS1 Galectin-1 0 351619000.0 136970000.0 66309000.0 148340000.0 False True 132621962.32358757 92786529.49686679 109485303.89539012 1.0 0.6996317040647813 0.825544291286041 26.982744466009834 -10.08490280492276 5.015608584994227 1.0000061056698661 0.7625879978825584 0.8257930602497005 0.05140359848434496 3.5096514015298223e-06 6.403034890393334e-07 0.0497726000747166 0.016590440071599055 8.224266883926067e-11 10.08490280492276 -0.23741810778730776 SFVLNLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFVLNLGK 8 0 P09382 P09382 LGALS1 Galectin-1 0 317462000.0 98492000.0 114480000.0 104490000.0 False True 149419564.72969943 94050149.56367749 83837505.70040609 1.0 0.6294366452868108 0.5610878726093765 27.154793823494497 -13.999999999999998 0.23772670033841628 3.426035874872752 0.5302084614611365 0.9995212636740265 0.004219011027866811 13.544254209224151 0.15432959044546338 15.578318903980207 0.033849789424834645 1.0000000000000041e-14 13.999999999999998 -2.8958274134116158 SFVLNLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFVLNLGK 8 0 P09382 P09382 LGALS1 Galectin-1 0 379440000.0 118820000.0 100720000.0 159900000.0 False True 162750964.98976424 96269857.36350001 122134913.24387163 1.0 0.5915163536483771 0.7504404858770144 27.278090856602375 -10.098359536768932 5.860315716792919 1.0000017113017967 0.6709784197626767 0.8510772118021785 0.06488050529586187 1.4506420116855414e-06 2.2331127301684152e-07 0.06282060579020267 0.02094009304202303 7.973343295714834e-11 10.098359536768932 -0.32902329153912 SFVLNLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFVLNLGK 8 0 P09382 P09382 LGALS1 Galectin-1 0 274194000.0 136970000.0 83805000.0 53419000.0 False True 113896623.79983768 83353525.83100994 64588665.91845057 1.0 0.7318349135396297 0.5670814793593787 26.76314974144411 -9.893309740727178 0.08644584790866544 1.8020653590598634 3.4517394636602266e-11 0.9999616181756134 0.001105296332374254 1.4663400572902223 0.03921050844560692 0.5419779552514719 0.2858425308958347 1.27846916911433e-10 9.893309740727178 -1.802065359025346 SFVLNLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFVLNLGK 8 0 P09382 P09382 LGALS1 Galectin-1 0 325751000.0 98492000.0 135360000.0 91899000.0 False True 127499835.56757236 127827097.00899704 75174324.9633688 1.0 1.0025667597135939 0.5896033091237041 26.925920145586947 -6.90549875177712 0.925830312065537 1.0146765947427692 0.5410680142332803 0.9891095180488473 0.020252724256042288 0.10747076333076891 0.1554647733951744 0.01622066481317734 0.043496490345600165 1.2430862086425324e-07 6.90549875177712 -0.47360858050948884 SFVVSK(ub)FR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFVVSKFR 8 1 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;P18583-6;P18583-8;J3QSZ5;P18583-3 P18583-2;P18583-3 SON Protein SON 1 23908100.0 4247000.0 9353100.0 10308000.0 True False 4112181.3096902613 13087841.605772164 7608025.566628553 1.0 3.18270052318242 1.8501191931154433 21.97147244495139 -10.334112513441301 6.002254022082465 0.9998472466699981 2.516409858148933 0.6332389892252717 0.5440240499039101 0.0011121582836626897 0.00012338394888887385 0.5267997105071338 0.17558300710117883 4.633268692727535e-11 10.334112513441301 1.516562611478935 SFVVSK(ub)FR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFVVSKFR 8 1 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;P18583-6;P18583-8;J3QSZ5;P18583-3 P18583-2;P18583-3 SON Protein SON 1 21071400.0 4247000.0 9455800.0 7368600.0 True False 3531568.674000946 9404859.728570655 8909340.191443019 1.0 2.6630827818267524 2.522771327380007 21.751877720385668 -10.43161376899955 5.391976568243151 0.9986276340858158 2.592927054603369 0.9942145670347621 0.05728191141043233 0.0009455498683208307 9.967341678747891e-05 0.05549446884782642 0.018487657410953765 3.701572252740316e-11 10.43161376899955 1.5942994205175531 SFVVSK(ub)FR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFVVSKFR 8 1 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;P18583-6;P18583-8;J3QSZ5;P18583-3 P18583-2;P18583-3 SON Protein SON 1 23282000.0 6676000.0 10261000.0 6345000.0 True False 8642213.603633923 9689966.329856077 5190275.105197826 1.0 1.1212366153252205 0.6005724161938548 23.04296945879093 -6.845396585417809 1.257223015008963 1.0645226349710784 0.5815495732039057 0.9333107910069942 0.05744449803908558 0.16260091645724814 0.4969140389182587 0.03579318392454683 0.08261400972432821 1.427589728610648e-07 6.845396585417809 -0.4829730617671727 SFVVTSVVAFPTDSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFVVTSVVAFPTDSK 15 0 Q9Y5Y6 Q9Y5Y6 ST14 Suppressor of tumorigenicity 14 protein 0 5467800.0 2537700.0 1986600.0 943500.0 False True 3326949.275121762 1690207.023706148 845875.6706910701 1.0 0.5080351048166457 0.25424964456667654 21.66576843942588 -9.38094630610601 0.19674638866197589 1.47955535025688 1.2049649663203659e-19 0.999532361903622 0.006694732763849008 0.8033492048748673 0.07476702623066696 0.37625585399926675 0.14488947186281992 4.15962034681328e-10 9.38094630610601 -1.47955535025688 SFVVTSVVAFPTDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFVVTSVVAFPTDSK 15 0 Q9Y5Y6 Q9Y5Y6 ST14 Suppressor of tumorigenicity 14 protein 0 7732500.0 2537700.0 2723900.0 2470900.0 False True 3475956.2687638877 2603549.0912672537 1887324.309782883 1.0 0.7490166417407554 0.5429654931919063 21.72897850094877 -6.9733812600121245 0.15772673366168424 1.215160433724891 0.07136568164077797 0.9999981820228254 0.00025191383949948136 0.07522005243977202 0.004857706100220867 0.009747706073320808 0.02493687803788974 1.0632092344354939e-07 6.9733812600121245 -1.143794752084113 SFYGSTLFLCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFYGSTLFLCR 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 70275000.0 15435000.0 28096000.0 26744000.0 False True 20235434.472752646 23904186.317350253 23976787.426562786 1.0 1.1813033394236059 1.1848911600513414 24.270380489495448 -12.24320374913894 0.5887510638088176 0.004901125299209342 1.1844736476423217 0.9999659277235943 0.0005038603169812299 9.967258794446863 0.29369028941769215 12.614562267962702 0.0006339889543265398 5.712105905055615e-13 12.24320374913894 1.1795725223431124 SFYGSTLFLCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFYGSTLFLCR 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 62530000.0 23515000.0 0.0 39015000.0 False True 35673974.17677459 0.0 31303668.14911799 1.0 0.0 0.877493154925759 25.08836860908123 -9.637394837847221 10.048020602622687 0.9999990566836513 0.4387465774628548 0.35294680376620224 0.35823508039259677 0.0 0.0 0.34685962509676355 0.1156198750322545 2.304650967755676e-10 9.637394837847221 -0.5612524792207965 SFYGSTLFLCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFYGSTLFLCR 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 62870000.0 15435000.0 17262000.0 30173000.0 False True 21141736.615191158 16499307.762199562 23046758.83244116 1.0 0.7804140247563282 1.0901071776611373 24.33359055101834 -6.716236611217673 1.7726972811494455 0.8658740289980303 1.0895307542479433 0.494774395431281 0.09244767874167892 0.3626808451071832 2.225218216243899 0.04144068254632005 0.1045012064180129 1.9220442803140235e-07 6.716236611217673 0.22365672524991298 SFYGSTLFLCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFYGSTLFLCR 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 75714000.0 23515000.0 31796000.0 20403000.0 False True 30440631.04994786 30026524.649069697 16689863.352458816 1.0 0.9863962609645416 0.5482758660644587 24.85949493117368 -6.913520059092819 0.8714105926992999 1.012102052755485 0.4871746868662215 0.9921837119950401 0.01854942008705395 0.10213639147962804 0.1264780627011517 0.015456069454114442 0.04378229712746029 1.22033745477925e-07 6.913520059092819 -0.5249273658892635 SFYK(ub)HILGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFYKHILGK 9 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 4536910.0 1396700.0 978710.0 2161500.0 True False 1352362.5230149261 1369514.0069052267 1595338.306389951 1.0 1.0126826081013125 1.179667640325717 20.367050510921224 -6.9220995406197545 0.8090060271427553 0.9965869201294671 1.2079399869311478 0.9947444606148049 0.005935222048778171 0.096952140357733 0.09932909548266096 0.005171494240783015 0.01581607151018643 1.1964662689150435e-07 6.9220995406197545 0.21135306680168064 SFYK(ub)HILGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFYKHILGK 9 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 4479600.0 1396700.0 1627700.0 1455200.0 True False 1161417.9343011829 1618931.2570268465 1759475.5919154114 1.0 1.393926517934258 1.5149375086704475 20.1474557863555 -12.120478106444702 0.19422956685135126 5.108410847664977e-08 1.606676532233204 0.9994231527711548 0.005280131435389002 5.578234949858374 0.12417025193048102 2.306768033261591 0.07996991207217831 7.577429310684721e-13 12.120478106444702 1.6066764811490954 SFYK(ub)HILGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFYKHILGK 9 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 14850600.0 6173000.0 3853500.0 4824100.0 True False 7991070.188021606 3639049.3375012623 3946163.299445993 1.0 0.45538948499740334 0.493821629218222 22.929957295451324 -10.191654901609049 5.979127569379737 1.0000077141264099 0.47460555710780794 0.9960029440689688 0.015689857177026728 1.6134320271383687e-06 2.181210298677554e-07 0.01519186169245542 0.005063879629247318 6.431986117656648e-11 10.191654901609049 -0.5254021570186019 SFYMQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFYMQR 6 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 7503500.0 1118200.0 3450700.0 2934600.0 False True 1465971.0286642052 2935869.0107232477 2630955.7426709244 1.0 2.0026787387458915 1.7946846774102043 20.48342516173486 -10.355921397359172 6.414265070367019 0.9999335775304197 1.898681708078048 0.9613770807750931 0.08491321996693045 8.066226213328386e-05 8.09960382975926e-06 0.0822228676500538 0.027405623900397354 4.406346064253605e-11 10.355921397359172 0.8987481305476284 SFYMQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFYMQR 6 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 6137200.0 1921400.0 1619300.0 2596500.0 False True 1860406.2087211849 2265894.9345379467 1916398.756669678 1.0 1.2179570912609934 1.0300969474763157 20.82718622900387 -10.510277800630693 3.1371431830277605 0.9963965884719043 1.124027019428105 0.3675563130036966 0.07669358327280386 20287675.020700485 24332889.209023613 623245.7909329319 0.027681154105905707 3.088319327485629e-11 10.510277800630693 0.12763043095620075 SFYMQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFYMQR 6 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 20869900.0 5616700.0 11666000.0 3587200.0 False True 8520944.535772463 9584111.153125977 2878188.3476743856 1.0 1.1247709820067657 0.3377780873459781 23.022581929534276 -6.866340872973977 1.1533630623219144 1.0692147180321354 0.2947993497385098 0.9608880748783774 0.06830098648863714 0.14040689843438053 0.35139547290509926 0.04605572073387951 0.10839128272868635 1.360376518721634e-07 6.866340872973977 -0.7744153682936257 down SFYMQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFYMQR 6 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 5086600.0 1118200.0 1802500.0 2165900.0 False True 1531628.7582187725 1722859.5899295965 1654359.0281107037 1.0 1.1248545580544063 1.0801305598588147 20.546635223257752 -10.372846876052837 4.786248395620307 0.9998979103527736 1.102492558956664 0.8750362822062538 0.018258495806243266 1.9910208879759796e-05 2.608863477126324e-06 0.017696299807986808 0.005892904182005364 4.23792360810789e-11 10.372846876052837 0.10259464860389045 SFYMQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFYMQR 6 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 4694200.0 1921400.0 1589200.0 1183600.0 False True 1597729.2324524184 1580638.6641684999 1431085.287651924 1.0 0.9893032136254492 0.8956995081421236 20.607591504438147 -6.928466483420128 0.7592715576616111 1.0015073613167935 0.8772124966133001 0.996228201105435 0.002877312292338722 0.09344197263515112 0.08163796742180483 0.0025978454728731665 0.00854205686245166 1.1790535129248306e-07 6.928466483420128 -0.12429486470349338 SFYMQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFYMQR 6 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 12808400.0 5616700.0 4197100.0 2994600.0 False True 7270928.871709199 3963527.6954525807 2449613.527190763 1.0 0.5451198554388915 0.336905169946316 22.793708251626725 -12.213950369060203 0.1260286130058356 2.421576781962975 2.3098202263904826e-17 0.9997231789220882 0.004606713620808471 6.052500109226143 0.09107939527772681 2.5054736831634337 0.261232407640561 6.1101184702111e-13 12.213950369060203 -2.421576781962975 SFYPEEVSSMVLTK ddPTM_RPMI8226_Bortezomib_1h_R1 2 SFYPEEVSSMVLTK 14 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 261954700.0 53694400.0 88399300.0 119861000.0 False True 70393878.37730919 75210469.01777263 107458933.50789873 1.0 1.0684234304387472 1.5265380454238067 26.068946638263068 -6.933560979123862 0.7169561619187815 0.9938695620724612 1.6297260346802982 0.9971930822658251 0.012384678784892019 0.09083032326634612 0.06892699763562052 0.011532372121849493 0.04067030658176416 1.1653034195375888e-07 6.933560979123862 0.635856472607837 SFYPEEVSSMVLTK ddPTM_RPMI8226_Bortezomib_2h_R1 2 SFYPEEVSSMVLTK 14 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 234475100.0 85638100.0 38544000.0 110293000.0 False True 82919565.39142603 53934820.204304695 81403954.58092389 1.0 0.6504474541045003 0.9817219156498515 26.305209219041913 -10.5894344028424 9.072520771598754 1.0000346539694362 0.8160846852561902 0.2912622399935868 0.1352422326002263 9.481493932227308e-05 4.290856821169015e-06 0.13097233385979667 0.04364924288038218 2.573745481403449e-11 10.5894344028424 -0.1839499687132461 SFYPEEVSSMVLTK ddPTM_RPMI8226_Bortezomib_8h_R1 2 SFYPEEVSSMVLTK 14 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 390234100.0 54002600.0 294582000.0 41649500.0 False True 81925892.3188894 242011540.52032858 33417458.069375664 1.0 2.9540299613499448 0.40789861573067915 26.287816145583793 -6.701632284732557 1.8248771247981703 2.211374086248439 0.41515932805166794 0.4255137531199078 0.824567148257798 0.3920749038014217 2.5395051844984557 0.3603096618458598 0.9248178064921029 1.9877772474806767e-07 6.701632284732557 -1.796214758196771 SFYPEEVSSMVLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SFYPEEVSSMVLTK 14 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 221409200.0 53694400.0 83226400.0 84488400.0 False True 73546670.71659978 79549182.45509933 64533980.013217784 1.0 1.0816150028276503 0.8774561701356824 26.13215669978596 -6.798208008266569 1.4631283084669302 1.0451334831486214 0.874758145357817 0.8268980859576697 0.034908665163152726 0.22332475452020292 0.9440116746342145 0.01877104615416007 0.04370479453750693 1.5914463105565335e-07 6.798208008266569 -0.17037533779080438 SFYPEEVSSMVLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SFYPEEVSSMVLTK 14 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 168065300.0 85638100.0 45610000.0 36817200.0 False True 71211874.56109278 45364289.87712378 44515506.29650087 1.0 0.6370326600264635 0.6251135301642838 26.08561449447619 SFYPEEVSSMVLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SFYPEEVSSMVLTK 14 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 172545600.0 54002600.0 63818200.0 54724800.0 False True 69907430.2503896 60266661.06929353 44765447.92386595 1.0 0.8620923534656412 0.6403532180131377 26.058942467676243 -6.964077774607219 0.37354956522507016 1.0163802865506495 0.47830373484644617 0.9998928423029032 0.0015335809741167845 0.07827540650175173 0.01597254945777405 0.0029078723008355853 0.018796977924307196 1.08623108105618e-07 6.964077774607219 -0.5380765517042033 SFYPEEVSSMVLTKMK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 2 SFYPEEVSSMVLTKMK 16 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 39688900.0 9819700.0 16247000.0 13622200.0 True False 12873721.794110063 13823010.93030997 12212705.417369265 1.0 1.0737385156664037 0.9486538246427522 23.617925861335184 -6.747000241308062 1.6613465469713538 1.0435157998166893 0.9484669796047314 0.6358012841817231 0.030981688967912337 0.3053045349785314 1.657045982593483 0.014738802785861878 0.0358896432418504 1.7906048591170373e-07 6.747000241308062 -0.09504882021195793 SFYPEEVSSMVLTKMK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 2 SFYPEEVSSMVLTKMK 16 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 42947600.0 14783100.0 12562600.0 15601900.0 True False 14313818.582359826 17578911.69309354 11515294.343032803 1.0 1.2281077611782485 0.8044879342835958 23.770905263944 -6.76045847877383 1.6108783221291345 1.132421922843631 0.8029117170193796 0.6928016175940755 0.09594851159966311 0.2821393435306371 1.443086523950217 0.04699460085810863 0.11287830959764174 1.7359672240918355e-07 6.76045847877383 -0.3295102058242514 SFYPEEVSSMVLTKMK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFYPEEVSSMVLTKMK 16 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 69567600.0 22559600.0 25632000.0 21376000.0 True False 34224562.52767864 21057769.336269934 17151024.230566368 1.0 0.6152823522357592 0.501132022263125 25.02852876469596 -13.999999999999998 0.1702935215818111 2.9416371410062987 0.40075236994939273 0.9995131206906385 0.004709034425936583 12.094384323196953 0.13068405616807513 7.757497551497104 0.09281718586869175 1.0000000000000041e-14 13.999999999999998 -2.540884771056906 SFYPEEVSSMVLTKMK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SFYPEEVSSMVLTKMK 16 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 32020800.0 14783100.0 12233800.0 5003900.0 True False 12292802.652371898 12167894.091180831 6050192.354580483 1.0 0.9898388866458402 0.49217355274251456 23.551310539378278 -6.911313833641217 0.8867432104514517 1.0147758013924293 0.4260186153864261 0.9914079309513965 0.02197139612862132 0.1035555356334971 0.13410318949338737 0.018105954971213117 0.05044731294314137 1.226552568789125e-07 6.911313833641217 -0.5887571860060032 down SFYPEEVSSMVLTKMK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SFYPEEVSSMVLTKMK 16 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;E9PN25;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 1 81922000.0 26271000.0 32647200.0 23003800.0 True False 34008327.37882963 30830354.62080476 18817344.438920364 1.0 0.9065531002855738 0.5533157873160873 25.01938471637291 -6.94617494145043 0.5993689390714039 1.0039842812771862 0.43782184857945433 0.9988658919322622 0.006478152890515035 0.08505903559397388 0.04260626783671543 0.00665294140506302 0.02967907273086409 1.1319443043267221e-07 6.94617494145043 -0.5661624326977319 SFYPYIHVVNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFYPYIHVVNK 11 0 Q9UGU0-2;Q9UGU0 Q9UGU0-2 TCF20 Transcription factor 20 0 9126000.0 2229300.0 1890300.0 5006400.0 False True 2922633.8885719078 1608274.608331691 4488385.752779834 1.0 0.5502826113870681 1.535733151637752 21.47883768679427 -6.782626679851006 1.525647476342546 0.7462291137493595 1.5441908916330698 0.7765766323490852 0.19040321237294766 0.2465115457307652 1.1334711752767763 0.09828039964863866 0.23139553061898727 1.6495797633412811e-07 6.782626679851006 0.7979617778837103 SFYQFQHYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFYQFQHYR 9 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 18212900.0 5295700.0 4487500.0 8429700.0 False True 6942713.983631756 3817982.4921379974 7557475.507392172 1.0 0.5499265130522918 1.0885477243063428 22.72706830782373 -6.684954982237555 1.883951429728853 0.7165202092895067 1.0866024461833392 0.3471321961528868 0.19054692221930156 0.42758428824052863 2.938156204807894 0.08102666874235662 0.212381256180631 2.0655942584902008e-07 6.684954982237555 0.3700822368938326 SFYQFQHYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFYQFQHYR 9 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 6316980.0 2360280.0 1208700.0 2748000.0 False True 2285354.20335195 1691340.21328723 2028216.3617671027 1.0 0.7400779322551078 0.887484469056175 21.12398635290825 -10.156745023795784 5.001254752845175 1.0000112899031413 0.8137812008288459 0.6802972238160525 0.060178466653477404 7.575999857841833e-06 1.277296682738699e-06 0.058271081451975786 0.019422516595590137 6.970356266913119e-11 10.156745023795784 -0.1862300890742954 SFYQFQHYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SFYQFQHYR 9 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 19380700.0 8568900.0 6692400.0 4119400.0 False True 12999647.770502385 5498088.9320401335 3305198.7844028403 1.0 0.4229413772668438 0.2542529492147238 23.631969197724207 -13.999999999999998 0.1724265965569092 3.9290714845225843 0.10923031645245432 0.9995092587061515 0.007073420872408826 12.116081385516887 0.13153912954931452 11.873357584710572 0.1345497848067967 1.0000000000000041e-14 13.999999999999998 -3.81984116807013 SFYQFQHYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFYQFQHYR 9 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 13873100.0 5295700.0 4343100.0 4234300.0 False True 7253663.4009114215 4151207.4812888945 3234245.5481458767 1.0 0.5722911654223294 0.44587753379064904 22.79027836934662 -13.999999999999998 0.17085081525629386 3.161793959398682 0.33537029087683023 0.9995120803483081 0.005237375546367624 12.099922069485181 0.13090850550488004 8.669825376218338 0.10227057892999511 1.0000000000000041e-14 13.999999999999998 -2.826423668521852 SFYQFQHYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SFYQFQHYR 9 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 9129880.0 2360280.0 4370300.0 2399300.0 False True 1962677.3981330239 4346756.326463372 2900982.5368902134 1.0 2.214707486109627 1.4780740531529748 20.904391628342527 -10.078287486852718 4.8626983738132505 0.9999725677307394 1.8463907696379689 0.6377157671332829 0.30072933973026567 9.095579882317156e-05 1.7240105863443416e-05 0.2911894997025431 0.0970599770370662 8.350500630374889e-11 10.078287486852718 0.8464182019072295 SFYQFQHYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFYQFQHYR 9 0 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 0 20549200.0 8568900.0 5275500.0 6704800.0 False True 11092609.968271231 4981913.787462794 5484595.197057579 1.0 0.44912007198601783 0.4944368559559429 23.403095519816656 -9.948244793690268 7.2242729844838935 1.0000000133245739 0.471778465458173 0.9945102002542984 0.018500499585043947 3.9710419179197055e-09 5.911736334048946e-10 0.01791303196427142 0.0059710105657824475 1.1265622809989622e-10 9.948244793690268 -0.528221547866401 SFYSSHYAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SFYSSHYAR 9 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8;Q8NEY8-5;F8VPY7;F8VWU8 F8WF16 PPHLN1 Periphilin-1 0 3522080.0 840460.0 874850.0 1806770.0 False True 1101851.1990262168 744325.7901385899 1619822.7721616405 1.0 0.6755229660741876 1.4700921264079865 20.07149797569985 -6.79582858348613 1.4728720876857508 0.8200135248948873 1.4799646702972529 0.8196844104721 0.1385128917864708 0.22676966280783753 0.9715897333598023 0.07399859712140859 0.17254994725410072 1.6001895005564615e-07 6.79582858348613 0.6599511454023655 SFYSSHYAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SFYSSHYAR 9 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8;Q8NEY8-5;F8VPY7;F8VWU8 F8WF16 PPHLN1 Periphilin-1 0 2753980.0 765170.0 855410.0 1133400.0 False True 740880.0971828816 1196979.6739042185 836528.5387288326 1.0 1.6156186115075941 1.1291011081410396 19.498880552465156 -10.184224342866404 4.372939777649164 0.9998998123448188 1.3723598598366362 0.43852702955659195 0.19861993907320688 139409570.63003138 26.810886276387414 141548.92200454613 0.06799288811905646 6.542980969421915e-11 10.184224342866404 0.3724600474918174 SFYSSHYAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SFYSSHYAR 9 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8;Q8NEY8-5;F8VPY7;F8VWU8 F8WF16 PPHLN1 Periphilin-1 0 3250660.0 840460.0 638830.0 1771370.0 False True 1151200.774577488 610604.3782716906 1353008.8885103 1.0 0.5304065040225444 1.175302274276943 20.13470803722274 -6.711443337606183 1.7899180757823654 0.711728777585469 1.1738605948569485 0.4719720520805778 0.19784064785516456 0.37220594734136786 2.3253791341668855 0.08792686936385269 0.22299733898633123 1.9433752274222108e-07 6.711443337606183 0.46213181727147945 SFYSSHYAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SFYSSHYAR 9 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8;Q8NEY8-5;F8VPY7;F8VWU8 F8WF16 PPHLN1 Periphilin-1 0 8799200.0 3028400.0 2707800.0 3063000.0 False True 3920323.4986885837 2557108.549652497 2505565.4290340287 1.0 0.6522697809269806 0.6391221106809639 21.90254127741393 SGAFGHLFRPDNFIFGQSGAGNNWAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGAFGHLFRPDNFIFGQSGAGNNWAK 26 1 A0A0B4J269;Q13509;Q13509-2;G3V2A3;G3V542 A0A0B4J269 TUBB3 Tubulin beta-3 chain 0 49398800.0 9893900.0 14859500.0 24645400.0 False True 9579823.560147049 20792975.84126883 18190030.39384821 1.0 2.1704967435694256 1.8987855339549695 23.191567654174463 -10.082107302536116 4.487243662242083 0.999922074393731 2.034641138793008 0.9508192811037688 0.11092563701766295 19269260.22883972 2.6063426785764774 15669.013955489168 0.03797279597143188 8.27737626644745e-11 10.082107302536116 1.034719064399277 SGAFGHLFRPDNFIFGQSGAGNNWAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGAFGHLFRPDNFIFGQSGAGNNWAK 26 1 A0A0B4J269;Q13509;Q13509-2;G3V2A3;G3V542 A0A0B4J269 TUBB3 Tubulin beta-3 chain 0 42482200.0 9893900.0 11394900.0 21193400.0 False True 8227216.224087119 11333513.411989434 25624841.95279001 1.0 1.3775635771924768 3.1146430645358794 22.97197292960874 -6.941677200495555 0.6437702993638412 0.980925975665415 3.6071345685771017 0.9983754436630047 0.0371156603114263 0.08700972652655335 0.05118711637525102 0.03660616493053361 0.1484371171273946 1.1437281215447751e-07 6.941677200495555 2.626208592911687 up SGAIFTK(ub)AYQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGAIFTKAYQR 11 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 10756200.0 4105300.0 4096600.0 2554300.0 True False 5382088.055781748 3485403.2484217347 2290005.5385757326 1.0 0.6475931297105989 0.42548644965324883 22.3597345642788 -8.704388179043253 0.14264882960543407 1.4701089629344768 9.530926176978618e-11 0.9998992282571831 0.0023745670998531966 0.2613052221279332 0.03958372420942412 0.2110662719771524 0.1612048987181279 1.9752033839135595e-09 8.704388179043253 -1.4701089628391675 SGAIFTK(ub)AYQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGAIFTKAYQR 11 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 16010500.0 3275100.0 3800100.0 8935300.0 True False 3171133.7431991016 5317499.74725971 6594876.876745851 1.0 1.6768449954732316 2.0796590149782865 21.596567294000607 -9.127827842917482 0.13990976164696053 3.284290895338533e-20 2.8311151835174795 0.9998627146644692 0.005219589783267579 0.5887341310251422 0.048369654763314056 0.5802781815724994 0.3401094368992683 7.450272488965557e-10 9.127827842917482 2.8311151835174795 SGAIFTK(ub)AYQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGAIFTKAYQR 11 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 22914400.0 1936300.0 2228400.0 18749700.0 True False 2937508.66249154 1830724.6094313336 15043813.576714544 1.0 0.623223561110641 5.121283136559216 21.486161675406972 -6.886556231058656 1.042507688285452 0.7379879435690586 5.483074203340101 0.9786021942868535 0.29803258395462134 0.12198310118593868 0.23850953626392238 0.2187448862183358 0.5390091556293201 1.2985054266203867e-07 6.886556231058656 4.745086259771043 up SGAIFTK(ub)AYQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGAIFTKAYQR 11 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 12736200.0 4105300.0 2738600.0 5892300.0 True False 5623140.351561004 2617599.5966608566 4500660.095727735 1.0 0.46550493727836645 0.8003819599626987 22.42294462580169 -10.64884221322107 5.1582303692590035 1.0056673523962574 0.632943448620553 0.6156647095900969 0.13671297202651023 0.009006993080177442 0.0006131703040404981 0.13380821801796158 0.04412392198909906 2.2446973134337248e-11 10.64884221322107 -0.3727239037757044 SGAIFTK(ub)AYQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGAIFTKAYQR 11 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 17626600.0 3275100.0 6709100.0 7642400.0 True False 2723390.761530611 6672956.746647914 9240390.50553486 1.0 2.4502384457298927 3.392972700084191 21.376972569434884 -8.334046145784413 0.20325123339001513 8.223166184023288e-16 4.506941574782351 0.9997257070665065 0.01630049828136686 0.1043682664871211 0.047578574536136405 0.43870859644717486 0.4269300688612157 4.633976789874657e-09 8.334046145784413 4.50694157478235 SGALLACGIVNSGVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGALLACGIVNSGVR 15 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 53374000.0 15357000.0 15066000.0 22951000.0 False True 20133175.717399552 12818211.526808042 20576250.681537643 1.0 0.6366711196848219 1.022007206928372 24.263071418705497 -11.030568524432601 12.754599070129547 1.4188158864515696 0.8293391633031315 0.20731387417647928 0.15731279887121333 0.043668040653190895 0.00010465785389135928 0.003550246419557658 0.0507724875144572 9.320333993992764e-12 11.030568524432601 -0.5894767231484381 SGAPAAESK(ub)EIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGAPAAESKEIVR 13 1 Q9NRX4;Q9NRX4-2 Q9NRX4 PHPT1 14 kDa phosphohistidine phosphatase 1 11452500.0 1638500.0 2151100.0 7662900.0 True False 2121070.5496635973 2031389.3940311314 6268330.827993755 1.0 0.9577189190398738 2.955267484614274 21.016361176971092 -6.902065366686529 0.9481164709624783 0.921589932653647 3.173966852018518 0.9875661895909402 0.10390752318897825 0.10990100345228035 0.16896884446409527 0.0818653188923825 0.21529435154358348 1.252952575901894e-07 6.902065366686529 2.2523769193648713 up SGAPVLSLLSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGAPVLSLLSVR 12 0 F5H0C4;Q9BRP4-2;Q9BRP4;Q9BRP4-3 F5H0C4 PAAF1 Proteasomal ATPase-associated factor 1 0 18413600.0 6681600.0 4960200.0 6771800.0 False True 8759642.304706438 4220157.494708169 6071119.095692422 1.0 0.48177281079625084 0.6930784254090481 23.06244052867548 -10.228165069107753 5.514978878613366 1.0000228480381923 0.5874256181026256 0.835607767917262 0.08626515593117709 2.4235510863110062e-05 3.391927446494006e-06 0.08353049611973347 0.027841959356606986 5.91336832801876e-11 10.228165069107753 -0.4125972299355667 SGAPVLSLLSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGAPVLSLLSVR 12 0 F5H0C4;Q9BRP4-2;Q9BRP4;Q9BRP4-3 F5H0C4 PAAF1 Proteasomal ATPase-associated factor 1 0 14335200.0 4600200.0 1836400.0 7898600.0 False True 4454169.169022175 2569684.096699487 5829719.707079193 1.0 0.5769165918912799 1.3088231465530513 22.086724921943507 -6.749961822815244 1.6498456297441007 0.7512090293695465 1.3102852535368736 0.6488386159145767 0.17778303495344355 0.30012384692943356 1.6072829891220628 0.08512147774941253 0.20667160855824948 1.7784357387247898e-07 6.749961822815244 0.5590762241673272 SGAPVLSLLSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGAPVLSLLSVR 12 0 F5H0C4;Q9BRP4-2;Q9BRP4;Q9BRP4-3 F5H0C4 PAAF1 Proteasomal ATPase-associated factor 1 0 17186600.0 6681600.0 4552100.0 5952900.0 False True 9151968.083450666 4350973.170218309 4546947.62382391 1.0 0.4754139361659372 0.4968273034131392 23.125650590198372 -10.527840693195005 6.86050365735229 1.000296217382804 0.4861206197895382 0.9986993998816788 0.008741970571745092 3.9629480958409746e-05 2.7274160845301633e-06 0.008469069602963836 0.002821458869783674 2.9659191409775765e-11 10.527840693195005 -0.5141755975932658 SGAPVLSLLSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGAPVLSLLSVR 12 0 F5H0C4;Q9BRP4-2;Q9BRP4;Q9BRP4-3 F5H0C4 PAAF1 Proteasomal ATPase-associated factor 1 0 9754500.0 4600200.0 2815100.0 2339200.0 False True 3825270.1234139823 2799934.497546398 2828315.9047612194 1.0 0.7319573277736289 0.7393767795506687 21.867130197377783 -10.435916963656613 5.948168109686063 1.0001166515647597 0.7356670536621487 0.9994094626949489 0.003028978504155949 4.68772841685366e-06 4.4454802226917703e-07 0.002934082563819179 0.0009775986085513021 3.665076435678568e-11 10.435916963656613 -0.264449597902611 SGAQASSTPLSPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGAQASSTPLSPTR 14 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 12397500.0 1187800.0 5904500.0 5305200.0 False True 1557217.3026715629 5023571.61556073 4756268.795071827 1.0 3.225992677413928 3.054338522255031 20.570538849394147 -10.380050311542785 5.436872656882507 0.9990882833863716 3.140165599834508 0.9951984127577558 0.07007751539473867 0.0007746706820626242 8.833342377704638e-05 0.06787221126475744 0.022617420838936843 4.1682109336328174e-11 10.380050311542785 2.1410773164481363 SGAQASSTPLSPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGAQASSTPLSPTR 14 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 15584300.0 3995600.0 2088600.0 9500100.0 False True 3868761.8650808623 2922588.871905112 7011738.81310903 1.0 0.7554326096636155 1.8123986581847873 21.883440498249996 -6.845786784530136 1.2551102611387215 0.8698085927027724 1.8513697678784877 0.9339602033569286 0.11610049214699876 0.16215962300435796 0.49367599995023165 0.07245093399212725 0.16727939794796984 1.4263076628691767e-07 6.845786784530136 0.9815611751757153 SGAQASSTPLSPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGAQASSTPLSPTR 14 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 13393200.0 1187800.0 6240200.0 5965200.0 False True 1626961.759088049 5964487.3304181155 4556342.617150367 1.0 3.6660279795152366 2.8005222567150603 20.63374891091704 -10.422616757585265 5.665584704731772 0.9988040087328882 3.2332751181151425 0.898758261939918 0.3533412317198793 0.0053394329153899425 0.0005441429169874628 0.3422202274694471 0.11404039216495657 3.7790552590634825e-11 10.422616757585265 2.2344711093822545 SGAQASSTPLSPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGAQASSTPLSPTR 14 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 7062560.0 3995600.0 2111500.0 955460.0 False True 3322518.435092581 2100124.930400063 1155242.2684521019 1.0 0.6320882702164882 0.3477007851184162 21.663845773684272 -7.756746957395623 0.2166064435251748 1.1979188211211904 5.824624856113703e-17 0.9998600466896073 0.003158970906750855 0.12747482791909734 0.029665679148073852 0.05039295638465964 0.08560212617475053 1.7508665376024743e-08 7.756746957395623 -1.1979188211211904 down SGAQASSTPLSPTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGAQASSTPLSPTR 14 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 12944100.0 4784100.0 3570300.0 4589700.0 False True 6193111.7587095685 3371609.6664540675 3754421.6942988904 1.0 0.5444128570282082 0.6062254066413267 22.562233049980176 -10.3853140863562 5.871055757807389 1.0001045219308595 0.5753191318349233 0.9843597725195684 0.02523486770877009 3.453285612782555e-05 3.6155204537606537e-06 0.02443951975390921 0.008144518531650897 4.1179959356350115e-11 10.3853140863562 -0.4247853900959362 SGASSFGEK(ub)FSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGASSFGEKFSR 12 1 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;Q9Y2X0-4;Q9Y2X0-5;U3KQ43;B9TWZ6;B9TX12;B9TX11 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 37125200.0 2751000.0 7823400.0 26550800.0 True False 3561223.7303170976 7388020.912678693 21718826.83421379 1.0 2.074573650002285 6.098697660952603 21.763941643744545 -6.946390331967048 0.5971599382309994 0.9543761663558781 7.423889133192238 0.9988867026001039 0.07322406705850504 0.08496841365843504 0.04221656600331202 0.07536489623172621 0.33786788982459814 1.1313830500874166e-07 6.946390331967048 6.469512966836359 SGAVQK(ub)CSACR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGAVQKCSACR 11 1 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 6048900.0 2098800.0 2002200.0 1947900.0 True False 2751547.1248081103 1703479.5645144747 1746349.9935761916 1.0 0.6190988150469251 0.634679296542297 21.391811606748405 -9.933590244509595 6.957560285344711 1.000000014198037 0.6268890558033057 0.9986938899006331 0.006360704935094797 1.3950241631709017e-09 2.2423477586909828e-10 0.006158726254481996 0.0020529086903126586 1.1652248969993546e-10 9.933590244509595 -0.3731109583947313 SGAVQK(ub)CSACR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGAVQKCSACR 11 1 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 4512800.0 2098800.0 1290700.0 1123300.0 True False 2874783.0779373585 1233672.6062258696 857999.6750896879 1.0 0.42913589400666124 0.29845718853517744 21.455021668271296 -13.999999999999998 0.20715666909027708 4.2635390006309954 0.21933200888399126 0.9994886131784984 0.006888570680479418 12.681630943846464 0.14428086139955257 16.822532168886696 0.07897890300778017 1.0000000000000041e-14 13.999999999999998 -4.0442069917470045 SGAYLIPLLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGAYLIPLLER 11 0 P26196;Q8IV96 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 14294900.0 2485200.0 5703400.0 6106300.0 False True 3258121.2667110325 4852474.95167908 5474478.651765646 1.0 1.489347557826629 1.6802562592435224 21.635608871047264 -11.343151782175559 0.172196650345984 7.713116552488233e-18 1.874353931564206 0.999508725144891 0.0063498267097969775 3.8337395126926292 0.10369054489908568 1.6084971316390182 0.14873906801461098 4.537829956904536e-12 11.343151782175559 1.874353931564206 SGAYLIPLLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGAYLIPLLER 11 0 P26196;Q8IV96 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 13915400.0 6075100.0 3918500.0 3921800.0 False True 5882249.275841608 5483177.48470755 2894562.9285219135 1.0 0.9321565998957159 0.4920843699041931 22.487936492855557 -6.934207597317595 0.7114038890756134 1.0057619977770873 0.391229921390732 0.9973025587157641 0.011693743206336081 0.09051108571122768 0.0674028374095287 0.010934057943460408 0.03893888418533937 1.1635696979348347e-07 6.934207597317595 -0.6145320763863553 down SGAYLIPLLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGAYLIPLLER 11 0 P26196;Q8IV96 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 16501000.0 2485200.0 6723600.0 7292200.0 False True 3404045.6000047275 6426529.120028087 5569932.547573238 1.0 1.887909233653968 1.6362684881675797 21.698818932570155 -10.178534696365002 6.060084165625532 0.999991985863511 1.7620888609107794 0.9244080285271095 0.10273190415588965 1.112354017331947e-05 1.5077849680925833e-06 0.09947078218609239 0.033156579493325226 6.629263834826586e-11 10.178534696365002 0.7620968750472684 SGCK(ub)VDLGGFAGLFDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGCKVDLGGFAGLFDLK 17 1 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 11859400.0 2966100.0 3065700.0 5827600.0 True False 3839674.920571988 2895091.1000331147 4767036.596225508 1.0 0.7539938041426276 1.2415208825843445 21.872552742163506 -6.769524002190904 1.5762376385492598 0.858808530877842 1.2442150288680385 0.7287175094466314 0.10366690321388224 0.26721772846648273 1.3101700280223538 0.05184201028101857 0.12346139041800686 1.7001059911401863e-07 6.769524002190904 0.38540649799019644 SGDAAIVDMVPGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 SGDAAIVDMVPGK 13 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 32716100.0 3122500.0 14334100.0 15259500.0 False True 4093627.738333012 12195508.15388419 13680593.319459883 1.0 2.97914440037735 3.341924130363361 21.96494848348828 -10.060856277662294 0.3987706860574331 1.8589591797422183e-22 3.380847608170346 0.9989499718110051 0.033350262819268034 1.402205206698526 0.18006025988453547 1.7193561049729078 0.09244630771241268 8.692480444799083e-11 10.060856277662294 3.380847608170346 SGDAAIVDMVPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SGDAAIVDMVPGK 13 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 16789200.0 3122500.0 0.0 13666700.0 False True 4276972.632389653 0.0 10438906.9345217 1.0 0.0 2.440723341427887 22.02815854501117 -6.795463024414457 1.4744202222402905 0.44504023218068844 2.4707379611562468 0.818542056223394 0.42675466366444154 0.22730349122506505 0.9759610189046898 0.2277559213187432 0.5311939154203039 1.6015369964903e-07 6.795463024414457 2.025697728975558 SGDAAIVDMVPGK(ub)PMCVESFSDYPPLGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 SGDAAIVDMVPGKPMCVESFSDYPPLGR 28 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 32815500.0 12769800.0 12815100.0 7230600.0 True False 16741331.462919116 10903137.032868557 6482446.872812782 1.0 0.6512706027604941 0.38721214541214666 23.996910936338903 -7.730019576544641 0.19318500227312435 1.2331604856302267 2.9120212181771484e-13 0.9999184854049429 0.00226583530140733 0.13055589188182398 0.025052259319239937 0.05219493836362861 0.08551913199587168 1.8620032018861377e-08 7.730019576544641 -1.2331604856299356 down SGDAAIVDMVPGK(ub)PMCVESFSDYPPLGR ddPTM_RPMI8226_Bortezomib_2h_R1 3 SGDAAIVDMVPGKPMCVESFSDYPPLGR 28 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 178204700.0 86043300.0 56815200.0 35346200.0 True False 83311902.53922117 79501805.64735384 26087969.856729373 1.0 0.9542670761830985 0.31313616736153405 26.31201928834511 -6.921273894701367 0.8152334779966454 1.0135074191886373 0.20666045545255235 0.9945272469983663 0.023197127924286572 0.09742822246453796 0.10177632019340464 0.02012262668495692 0.06102985793364558 1.1987430583880275e-07 6.921273894701367 -0.8068469637360849 down SGDAAIVDMVPGK(ub)PMCVESFSDYPPLGR ddPTM_RPMI8226_Bortezomib_8h_R1 2 SGDAAIVDMVPGKPMCVESFSDYPPLGR 28 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 682026000.0 149444000.0 167221000.0 365361000.0 True False 226717473.81985506 137379106.0463635 293147238.2065851 1.0 0.60594846851338 1.2930068126972591 27.75632034745039 -6.751150209311141 1.645433489864665 0.768614751507434 1.294505384099673 0.6539542984811948 0.16559403089075894 0.2980504938115659 1.5880076092633608 0.07948583272011167 0.1927493541970224 1.7735759485772502e-07 6.751150209311141 0.525890632592239 SGDAAIVDMVPGK(ub)PMCVESFSDYPPLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 3 SGDAAIVDMVPGKPMCVESFSDYPPLGR 28 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 52493500.0 14724300.0 14863700.0 22905500.0 True False 20168271.619245775 14206972.586317085 17495692.65358039 1.0 0.7044219184731695 0.8674859692431428 24.26558411736494 -10.107860389739917 4.958242817085918 1.0000080735060408 0.7859539443132192 0.6967308177375502 0.06657061996604563 5.941386242766627e-06 1.0690902325430296e-06 0.06445915610428216 0.02148557520582474 7.800808385206212e-11 10.107860389739917 -0.21405412919282163 SGDAAIVDMVPGK(ub)PMCVESFSDYPPLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 3 SGDAAIVDMVPGKPMCVESFSDYPPLGR 28 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 181413800.0 86043300.0 50575800.0 44794700.0 True False 71548816.3144963 50303338.126889706 54161064.66270841 1.0 0.7030631772547982 0.75698058266458 26.092424563779385 -10.589276496883086 6.430319591342606 1.0006169431977 0.7300218799596911 0.9709556592601899 0.02201168858479048 0.00019511379530557743 1.2462484357558881e-05 0.021359645330966077 0.007104241942566457 2.5746814445777776e-11 10.589276496883086 -0.27059506323800875 SGDAAIVDMVPGK(ub)PMCVESFSDYPPLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 4 SGDAAIVDMVPGKPMCVESFSDYPPLGR 28 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 808405600.0 213590200.0 158333600.0 436481800.0 True False 276496724.3922847 149522195.97357953 357046591.08147126 1.0 0.5407738420851678 1.2913230414075538 28.04268714830753 -6.7411555293481475 1.6826665038539972 0.7271207485385267 1.2918555935948628 0.6099987375351374 0.19294300173154957 0.31574723985693764 1.7558410015233903 0.09069875985567871 0.2222676360931584 1.8148656075111097e-07 6.7411555293481475 0.5647348450563361 SGDAAIVDMVPGKPMCVESFSDYPPLGR ddPTM_RPMI8226_Bortezomib_1h_R1 3 SGDAAIVDMVPGKPMCVESFSDYPPLGR 28 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 132398300.0 16953500.0 82483200.0 32961600.0 False True 22226202.677927554 70177028.0769954 29551049.821993437 1.0 3.1574007082499502 1.3295590906916392 24.40575815078232 -6.605658706134098 2.170050894318276 2.4455466955203553 1.3358750897937872 0.037084869148354516 0.931155584719398 0.6246664881059703 5.567894138409728 0.3551594198315934 1.0343853578970967 2.4793697251877444e-07 6.605658706134098 -1.109671605726568 SGDAAIVDMVPGKPMCVESFSDYPPLGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 SGDAAIVDMVPGKPMCVESFSDYPPLGR 28 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 91049000.0 38045300.0 17468600.0 35535100.0 False True 36837572.77644435 24443903.077545546 26227391.27985084 1.0 0.6635590033547516 0.7119739250741799 25.13467466975726 -10.119520272704998 5.136411141407973 1.000009375051585 0.687766464214126 0.9822867216339155 0.01976530902655293 2.1220240306563628e-06 3.63733461459991e-07 0.019138252567892998 0.0063792260574691865 7.594159725851349e-11 10.119520272704998 -0.31224291083745903 SGDAAIVDMVPGKPMCVESFSDYPPLGR ddPTM_RPMI8226_Bortezomib_8h_R1 2 SGDAAIVDMVPGKPMCVESFSDYPPLGR 28 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 982141900.0 27223400.0 912672000.0 42246500.0 False True 41299888.09712968 749798550.8611172 33896460.757701226 1.0 18.1549777834199 0.820739772417374 25.299634536850572 -6.5220738338083795 2.5090322374174145 9.999999999999998 0.8155497065137196 0.25498195223910125 7.016944825116154 0.570587814781561 6.711700047837079 2.7048148394123492 8.864428393691876 3.0055652871645153e-07 6.5220738338083795 -9.184450293486279 SGDAAIVDMVPGKPMCVESFSDYPPLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 3 SGDAAIVDMVPGKPMCVESFSDYPPLGR 28 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 159632300.0 16953500.0 50799700.0 91879100.0 False True 23221667.101110667 48555201.28185655 70179148.88946232 1.0 2.0909438185656453 3.0221408559468035 24.46896821230521 -6.972964766592533 0.17330573764318236 0.21299156805325242 4.925109593850445 0.9999972321978108 0.001374835475008123 0.07535190449243075 0.005425140679369002 0.03807602648773927 0.1067197125003394 1.0642293534347509e-07 6.972964766592533 4.712118025797193 SGDSEVYQLGDVSQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGDSEVYQLGDVSQK 15 0 Q04837;A0A0G2JLD8;E7EUY5;C9K0U8 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 0 17503100.0 0.0 10569000.0 6934100.0 False True 0.0 8992146.397639325 6216625.848583949 0.0 SGDSEVYQLGDVSQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGDSEVYQLGDVSQK 15 0 Q04837;A0A0G2JLD8;E7EUY5;C9K0U8 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 0 19379300.0 6369000.0 3500800.0 9509500.0 False True 6166819.581214333 4898687.696430824 7018676.6711150855 1.0 0.7943620908504354 1.1381355622103364 22.556095208230523 -6.744713581494667 1.669640410942226 0.8783184031559794 1.1385436794294577 0.6258416903219034 0.0863967553864723 0.30934610647868194 1.6949816120301449 0.04090920163685795 0.09986501040090359 1.800057667149512e-07 6.744713581494667 0.26022527627347825 SGDSEVYQLGDVSQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGDSEVYQLGDVSQK 15 0 Q04837;A0A0G2JLD8;E7EUY5;C9K0U8 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 0 19532600.0 0.0 12519000.0 7013600.0 False True 0.0 11965869.185203107 5357132.129626133 0.0 SGDSEVYQLGDVSQK(ub)TTWHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGDSEVYQLGDVSQKTTWHR 20 1 Q04837;A0A0G2JLD8;E7EUY5;C9K0U8 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 1 20937500.0 2580500.0 3865000.0 14492000.0 True False 3383060.4895975473 3288357.0656520016 12992506.857080007 1.0 0.9720065827268694 3.8404595179513357 21.68989754227701 -6.904695169791539 0.9310916803088375 0.8956113620954069 4.172007384557414 0.9887613303486879 0.14265606676814357 0.1080317994478303 0.15856340507655248 0.11381382435272262 0.30375258914171094 1.2453884400915832e-07 6.904695169791539 3.2763960224620075 up SGDSEVYQLGDVSQK(ub)TTWHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGDSEVYQLGDVSQKTTWHR 20 1 Q04837;A0A0G2JLD8;E7EUY5;C9K0U8 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 1 38324500.0 3678900.0 7044900.0 27600700.0 True False 3562115.333228045 9857965.30866818 20371248.66674864 1.0 2.7674469764387823 5.718862743359826 21.76430279771835 -6.963413120879062 0.3843146725046691 0.8068486779244884 7.784549460077977 0.9998766054746008 0.02162315595034167 0.07850364678425924 0.0167846794909107 0.03825652611161391 0.2488895427713118 1.0878947454754308e-07 6.963413120879062 6.977700782153488 SGDSEVYQLGDVSQK(ub)TTWHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGDSEVYQLGDVSQKTTWHR 20 1 Q04837;A0A0G2JLD8;E7EUY5;C9K0U8 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 1 128876400.0 9752400.0 37018000.0 82106000.0 True False 14795103.79594202 30411848.67704586 65877713.11166187 1.0 2.055534661770144 4.452669884595924 23.81861648209285 -6.957485649257203 0.4695285400101211 0.9363941247103729 5.670003414770305 0.9996652820908795 0.026429046658849233 0.08061181127251268 0.024544829818050437 0.03311502054064424 0.19785550436460245 1.1028446754334507e-07 6.957485649257203 4.733609290059932 SGDSEVYQLGDVSQK(ub)TTWHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGDSEVYQLGDVSQKTTWHR 20 1 Q04837;A0A0G2JLD8;E7EUY5;C9K0U8 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 1 19039600.0 2580500.0 4009200.0 12449900.0 True False 3534580.585390393 3832060.2873485344 9509490.033739073 1.0 1.0841626594079434 2.6904153983771044 21.7531076037999 -6.917750364923183 0.8412394052286705 0.9616046220258759 2.9364963944548665 0.9935329211922829 0.06254854659588865 0.09951369852435248 0.11260549370180155 0.05325957039594371 0.1562633260517093 1.208508293324271e-07 6.917750364923183 1.9748917724289905 up SGDSEVYQLGDVSQK(ub)TTWHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGDSEVYQLGDVSQKTTWHR 20 1 Q04837;A0A0G2JLD8;E7EUY5;C9K0U8 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 1 24773100.0 3678900.0 7012800.0 14081400.0 True False 3059168.3529037167 6975020.654468195 17025755.634962663 1.0 2.2800381835303734 5.565485017783369 21.544708073152627 -6.954895039039789 0.5022385181442005 0.9354602590469251 7.052307703536584 0.999531541786019 0.041618053553444355 0.08157766244198708 0.028273266640999085 0.048604208071518606 0.27104236471456117 1.1094429147385082e-07 6.954895039039789 6.116847444489659 SGDSEVYQLGDVSQK(ub)TTWHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGDSEVYQLGDVSQKTTWHR 20 1 Q04837;A0A0G2JLD8;E7EUY5;C9K0U8 Q04837 SSBP1 Single-stranded DNA-binding protein, mitochondrial 1 91193600.0 9752400.0 34332200.0 47109000.0 True False 12624674.048543975 32421582.889570717 38535645.37915911 1.0 2.5681124728372655 3.0524071537200195 23.5897428041853 -9.859834681503303 0.3017871917283875 1.3282201415334626e-11 3.2244339162784463 0.9988337590137704 0.029914573529559587 1.247501846340829 0.13168015458034543 1.293314025442887 0.1704134818367311 1.3809098215703046e-10 9.859834681503303 3.224433916265164 SGDTHLFDK(ub)VR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGDTHLFDKVR 11 1 Q8NCE2-3;Q8NCE2-2;Q8NCE2 Q8NCE2-3 MTMR14 Myotubularin-related protein 14 1 3457390.0 693590.0 1202500.0 1561300.0 True False 576750.816246838 1196021.8938224376 1887760.611364437 1.0 2.0737237991364434 3.273095690872005 19.137588615121285 -6.969693834416786 0.26539868287057367 0.6847134188359396 4.697942791293912 0.9999798946753609 0.00416311367672999 0.07640219113750626 0.009385126022644094 0.024190856392206077 0.11227094527934166 1.0722749630027792e-07 6.969693834416786 4.013229372457972 SGDTHLFDK(ub)VR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGDTHLFDKVR 11 1 Q8NCE2-3;Q8NCE2-2;Q8NCE2 Q8NCE2-3 MTMR14 Myotubularin-related protein 14 1 12439000.0 3117600.0 2896800.0 6424600.0 True False 4035794.6570834517 2735590.5335081457 5255388.721962792 1.0 0.6778319428880644 1.302194281054107 21.944421340710008 -6.766457780476421 1.5878521028636778 0.8143719471894436 1.3052558399464387 0.7168255134002093 0.1356632439316613 0.272229490629376 1.3539713344484943 0.06736406687891792 0.16089162706763213 1.7121516137978188e-07 6.766457780476421 0.49088389275699507 SGDWVCPNPSCGNMNFAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGDWVCPNPSCGNMNFAR 18 0 Q92804-2;Q92804;A0A075B7D9;A0A075B7F4 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 0 13470300.0 1665800.0 6480700.0 5323800.0 False True 2183879.931630146 5513804.821570738 4772944.245495624 1.0 2.5247747102355516 2.185534184534075 21.058462109279976 -10.428636287682428 5.725874730532862 0.9992748436501324 2.355154447384814 0.9551097120683485 0.13849436467369677 0.0012826249687724494 0.00012798826144355322 0.13415596680721553 0.04469886399373273 3.727037069534067e-11 10.428636287682428 1.3558796037346814 SGDWVCPNPSCGNMNFAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGDWVCPNPSCGNMNFAR 18 0 Q92804-2;Q92804;A0A075B7D9;A0A075B7F4 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 0 12323600.0 1665800.0 5103500.0 5554300.0 False True 2281691.276552341 4878010.494982353 4242488.734399224 1.0 2.1378924244094395 1.8593614210637943 21.121672170802867 -10.081994508019372 4.48913979920485 0.999929661697799 1.998626922504217 0.9448716935077794 0.11370980618080394 26336915.387657806 3.1890711309042885 20572.64401404065 0.03892589112547949 8.279526337304071e-11 10.081994508019372 0.9986972608064181 SGDWVCPNPSCGNMNFAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGDWVCPNPSCGNMNFAR 18 0 Q92804-2;Q92804;A0A075B7D9;A0A075B7F4 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 0 12596800.0 3806300.0 4641300.0 4149200.0 False True 4927330.383390028 4383007.574969404 3394088.1743872017 1.0 0.8895298739748547 0.6888290230808619 22.23237477864391 -6.961879925288492 0.40808384247586005 1.0100956766188247 0.5608383031691037 0.9998336742196959 0.0016611278364882503 0.07903639551165786 0.01870012777335672 0.0025832139835461642 0.016767543460588844 1.0917421420386589e-07 6.961879925288492 -0.44925737344972105 SGEEDEEILFK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGEEDEEILFKER 13 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 23869300.0 8333800.0 8877000.0 6658500.0 True False 10925692.504633998 7552586.202274993 5969542.292842066 1.0 0.6912684206581556 0.5463765605988049 23.381221389368843 -13.999999999999986 0.10090160896294588 2.520735400777096 0.24204081983793824 0.9997891924692474 0.002746659293592059 12.073603912624039 0.09477965340649837 3.8145916676101703 0.27128998945171073 1.0000000000000327e-14 13.999999999999986 -2.278694580939158 SGEEDEEILFK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGEEDEEILFKER 13 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 24596400.0 7108400.0 10968000.0 6520000.0 True False 6882747.73294143 15347579.597364403 4812216.404192681 1.0 2.229862286526869 0.699170824053451 22.71455320246378 -6.692810604053801 1.8563226207737509 1.7690063888820307 0.7042644879752344 0.38363531107818727 0.5198527330760851 0.4106702611934058 2.7458188486506168 0.223845900423545 0.5808764259364735 2.0285671853717496e-07 6.692810604053801 -1.0647419009067962 SGEEDEEILFK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGEEDEEILFKER 13 1 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 1 104779000.0 33473000.0 52333000.0 18973000.0 True False 50780988.204089895 42993767.270404704 15222978.233838683 1.0 0.8466508587350018 0.29977711683469416 25.597785134487776 -6.947513957678212 0.585500437122075 1.0064111670511753 0.11271073071898864 0.9989914748690388 0.009544217009937945 0.08449962557965998 0.04021403130963244 0.009941320953398869 0.045753944598121606 1.1284596696710259e-07 6.947513957678212 -0.8937004363321867 down SGEEDFESLASQFSDCSSAK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGEEDFESLASQFSDCSSAKAR 22 1 Q13526;K7EMU7;K7EN45 Q13526 PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 1 15337900.0 6812100.0 4838800.0 3687000.0 True False 5664562.977198461 4812732.423973397 4457934.653238121 1.0 0.8496211346481743 0.7869865109069535 22.433533225290674 -13.999999998880492 0.12012037899622051 1.716665055790165 0.6871798419005372 0.9996923476176576 0.0015678537783295062 11.963332124542156 0.10668037745266958 2.046386758923505 0.08856813097887649 1.0000000025777625e-14 13.999999998880492 -1.029485213889628 SGEGTLLDLHQQK(ub)EAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGEGTLLDLHQQKEAAR 17 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 30870800.0 11371900.0 12859400.0 6639500.0 True False 14908671.025636269 10940827.645548591 5952508.230581196 1.0 0.7338566681587678 0.39926484529342254 23.829648324235524 -6.968025634009283 0.3016455414229612 1.0569062406365193 0.0657065807490502 0.9999626242494304 0.0015025774338239238 0.07694873849330948 0.01131130508984949 0.005506175104713658 0.029956132597626133 1.0764016776972346e-07 6.968025634009283 -0.991199659887469 down SGEGTLLDLHQQK(ub)EAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGEGTLLDLHQQKEAAR 17 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 74824600.0 29955000.0 22410800.0 22458800.0 True False 29004094.921538014 31359549.310778096 16576166.530442132 1.0 1.0812110977988476 0.5715112495419712 24.789753264656483 -6.866108814528784 1.1543895208248405 1.0450141609858863 0.5437763240352773 0.9606479174482918 0.04435727882263716 0.14064549453587685 0.3527316285159858 0.029884365548234124 0.0703170027801967 1.3611036088163856e-07 6.866108814528784 -0.501237836950609 SGEGTLLDLHQQK(ub)EAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGEGTLLDLHQQKEAAR 17 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 62981400.0 9885400.0 26794000.0 26302000.0 True False 14996874.519544415 22012401.357522503 21103398.171423893 1.0 1.4677992623619824 1.4071864203385351 23.838158525933316 -10.558016353736546 6.190472324956309 0.9991966896735877 1.4374928413502546 0.985808083240568 0.024745089136228558 0.00027481320279348106 1.9620938304158982e-05 0.024000164832537314 0.007986443177085942 2.7668374557783414e-11 10.558016353736546 0.4382961516766669 SGEGTLLDLHQQK(ub)EAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGEGTLLDLHQQKEAAR 17 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 25854200.0 11371900.0 9503300.0 4979000.0 True False 15576398.744042264 9083412.782789418 3803062.745723811 1.0 0.5831523018928676 0.2441554564837026 23.892858385758416 -7.842113277124539 0.2888699676971787 1.1214432866266075 4.5612477375264694e-10 0.9994483187444985 0.00726051391340478 0.11579590248350749 0.047087558693627074 0.04659645334909686 0.08526274338731905 1.4384233450467388e-08 7.842113277124539 -1.1214432861704828 down SGEGTLLDLHQQK(ub)EAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGEGTLLDLHQQKEAAR 17 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 83553400.0 29955000.0 38148000.0 15450400.0 True False 24908909.73150423 37942489.152214825 18681007.205421835 1.0 1.5232496950368732 0.7499728975208624 24.57015854009076 -6.724461821354883 1.743181132649092 1.316821723905402 0.7508622865630389 0.533429779955748 0.22007530713569337 0.34676564184872666 2.0615589786857864 0.10015073559405348 0.2501136062335753 1.8859847583294127e-07 6.724461821354883 -0.5659594373423632 SGEGTLLDLHQQK(ub)EAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGEGTLLDLHQQKEAAR 17 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 68376400.0 9885400.0 31938000.0 26553000.0 True False 12796845.170365896 30160622.224241666 21720626.45678766 1.0 2.3568795138731287 1.6973422876981334 23.609284848025766 -10.094125313083646 4.990481508843344 0.9999690357143047 2.0271109007899164 0.7637979336086089 0.26925494509807446 9.276564444114227e-05 1.6839520236215173e-05 0.2607128046752022 0.08690165985194487 8.05146087574973e-11 10.094125313083646 1.0271418650756117 SGELAQEYDK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGELAQEYDKR 11 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 22420600.0 7028600.0 5048400.0 10343600.0 True False 10662900.05948875 4147473.5766707687 8299182.926239076 1.0 0.3889629982023508 0.7783232403884122 23.346096534994313 -9.901236139849093 5.423972936771743 1.000000456878063 0.5836431192930918 0.6039037643106657 0.15895565325533725 8.78222030345961e-07 1.7801117487432937e-07 0.1539083191645163 0.05130271648575463 1.255347205525181e-10 9.901236139849093 -0.4163573375849712 SGELAQEYDK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGELAQEYDKR 11 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 16340700.0 7028600.0 5821500.0 3490600.0 True False 9098661.254419032 5497528.4074902255 2855346.616580536 1.0 0.6042128895413256 0.31382052114466324 23.117222857086762 -7.964024053333549 0.2253924610000073 1.2062875073477368 1.478377291680083e-12 0.9997573810959488 0.004380513258177968 0.10659178114461235 0.038894949377413994 0.0688920248040316 0.09737527712510431 1.0863654537660984e-08 7.964024053333549 -1.2062875073462584 down SGEVLVNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGEVLVNVK 9 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 29461600.0 10104000.0 8690600.0 10667000.0 False True 13246441.847275194 7393996.355693481 9563281.16508918 1.0 0.5581873563438798 0.7219509416452357 23.659101550780512 -10.052219137153584 5.775126374910844 1.0000012096641628 0.6400691489944994 0.8656064891732298 0.06685620373971819 1.041353606418728e-06 1.7086949206268717e-07 0.06473345890156638 0.021577746972851402 8.867084820507887e-11 10.052219137153584 -0.35993206066966343 SGEVLVNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGEVLVNVK 9 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 18780000.0 5430100.0 3063900.0 10286000.0 False True 5257724.44778647 4287331.24802742 7591788.026614404 1.0 0.8154347552071523 1.4439303736829698 22.326007103020515 -6.828093385168211 1.3365606737490847 0.9012453055135276 1.4601753486569418 0.9019767243795734 0.08258114394799702 0.18317756350599368 0.6406643853718158 0.0485233630625914 0.1116692949067755 1.4856161599134212e-07 6.828093385168211 0.5589300431434142 SGEVLVNVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGEVLVNVK 9 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 61263900.0 6084900.0 43979000.0 11200000.0 False True 9231238.165777404 36130603.84050467 8986315.090865603 1.0 3.9139499156733053 0.9734680147436998 23.138092735702866 -6.648248468490722 2.0147052201473903 2.8934729467346636 0.9857986792564168 0.18700858642861495 1.2442420040381268 0.512837106807603 3.987948951906654 0.5011997565963116 1.3781219994081697 2.2477682450795502e-07 6.648248468490722 -1.9076742674782468 SGEVLVNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGEVLVNVK 9 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 28846200.0 10104000.0 7241200.0 11501000.0 False True 13839721.850333096 6921259.840553786 8784700.670530127 1.0 0.5001010797328419 0.6347454642174544 23.722311612303404 -10.362913141251383 8.753126389496845 1.0000011469945536 0.5674232719751723 0.9322595180474746 0.05496833978640212 1.2303163673202774e-06 8.960943812625813e-08 0.053223006487594135 0.01774095538011716 4.335975890864756e-11 10.362913141251383 -0.4325778750193813 SGEVLVNVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGEVLVNVK 9 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 12143300.0 5430100.0 4164500.0 2548700.0 False True 4515368.744217701 4142065.0119114676 3081621.386142662 1.0 0.9173259697152576 0.6824739153560669 22.10641237845479 -6.952670377548797 0.5287141878041716 1.0037384941891605 0.5854234378732771 0.9993945303499859 0.0033095520043323725 0.08243082391981589 0.031659149075062114 0.0036993404834658517 0.019417835347722564 1.1151405860564523e-07 6.952670377548797 -0.4183150563158834 SGEVLVNVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGEVLVNVK 9 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 29919700.0 6084900.0 15073000.0 8761800.0 False True 7877023.001310979 14234174.299768114 7167242.303659932 1.0 1.8070499854322006 0.9098922654494067 22.909219057795315 -6.669704616690501 1.9387064956185411 1.5152841444111442 0.9135496473329204 0.2775747868896338 0.34284380964862415 0.46182242080589747 3.3462614101114796 0.14239098920320697 0.380539898803764 2.1394167087863375e-07 6.669704616690501 -0.6017344970782238 SGEVLVNVK(ub)EHSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGEVLVNVKEHSR 13 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 18017100.0 5950600.0 5401200.0 6665300.0 True False 7801294.225692373 4595362.0137127 5975638.694072284 1.0 0.589051236983035 0.7659804285284394 22.895282054593764 -10.215761472013336 5.460342303094706 1.0000168382745782 0.6775158327557074 0.8158216132893802 0.0722310399816696 1.4807010686418351e-05 2.1265679197244057e-06 0.06994105236082444 0.023312467910672176 6.084690996054857e-11 10.215761472013336 -0.32250100551887084 SGEVLVNVK(ub)EHSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGEVLVNVKEHSR 13 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 43564700.0 8467700.0 10695000.0 24402000.0 True False 8198897.498484633 14965569.273688206 18010384.15569172 1.0 1.8253148397640326 2.196683658872489 22.966998493639554 -10.006867170025403 0.19184621805154498 1.3381880774998243e-12 2.556031499432528 0.9994723231236283 0.01148844350505026 1.5352102303979616 0.08832615260325376 1.0316095957707323 0.2357779511940313 9.843121138698228e-11 10.006867170025403 2.55603149943119 SGEVLVNVK(ub)EHSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGEVLVNVKEHSR 13 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 172472400.0 16023000.0 21518000.0 134931400.0 True False 24308062.438207924 17677944.779098656 108262149.64746638 1.0 0.7272461482290785 4.453754795252527 24.534931566949176 -6.889292350057228 1.0265870777285004 0.7963594046918759 4.769828200659077 0.9804404893094014 0.23720350891978234 0.11971808211666651 0.2252299897982797 0.17622098070481032 0.4382062108182914 1.2903503677957624e-07 6.889292350057228 3.9734687959672015 up SGEVLVNVK(ub)EHSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGEVLVNVKEHSR 13 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 17770200.0 5950600.0 4524800.0 7294800.0 True False 8150697.628918457 4324879.374487344 5571918.4811219275 1.0 0.5306146260588527 0.6836124629814397 22.958492116116656 -10.381212367762037 5.121570403961364 1.0002661353922495 0.6071135445201169 0.8978788965490571 0.06246110536841736 0.00018993582999852522 2.2948122960879e-05 0.060518068765571205 0.020159235073117558 4.157072820676276e-11 10.381212367762037 -0.3931525908721326 SGEVLVNVK(ub)EHSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGEVLVNVKEHSR 13 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 36567700.0 8467700.0 13754000.0 14346000.0 True False 7041267.732714344 13679904.472044744 17345682.27159048 1.0 1.9428183945465836 2.463431718552744 22.74740376907383 -9.180660136135726 0.17810307493303218 3.087655493789303e-20 3.1167378820784477 0.9996775434384153 0.010876145746490368 0.6286416514093637 0.06338035964788599 0.6781178597974324 0.33337513924543727 6.596899438664123e-10 9.180660136135726 3.1167378820784477 SGEVLVNVK(ub)EHSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGEVLVNVKEHSR 13 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 147528000.0 16023000.0 24295000.0 107210000.0 True False 20742089.360549208 22942961.892978597 87698880.06749535 1.0 1.1061065977574747 4.228063940091581 24.306057889041625 -6.914120239050142 0.8672191094985415 0.9154738319000024 4.669190715989822 0.9923854848853545 0.1306597638039201 0.10175572865183102 0.12445928754167704 0.10920193810783352 0.31078262176643445 1.2186521553934995e-07 6.914120239050142 3.753716884089819 up SGFEGMFIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGFEGMFIR 9 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 0 3584830.0 718330.0 1105600.0 1760900.0 False True 941737.5863176157 940648.7895950453 1578698.9597455277 1.0 0.9988438427664039 1.676368218368091 19.84496558559217 -6.906513221480405 0.9191607208291261 0.9766395133591567 1.757695730701474 0.9895375723905311 0.03264109063630519 0.10676919318348713 0.15161230958068986 0.026271217878411357 0.07088185878645094 1.2401858688418855e-07 6.906513221480405 0.7810562173423173 SGFLVWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGFLVWR 7 0 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2;A0A087WWG9 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 0 18983400.0 5663400.0 4982400.0 8337600.0 False True 7424772.244443612 4239045.341243085 7474905.131906592 1.0 0.5709327103488473 1.0067521111506819 22.823915341116187 -10.94041002164962 10.824412068807991 1.047816767563117 0.7888424107497647 0.23838314890052426 0.17792252532833408 0.10423147543907524 0.0005738088878109597 0.08745771129388376 0.05742424812598378 1.147070150020318e-11 10.94041002164962 -0.25897435681335224 SGFLVWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGFLVWR 7 0 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2;A0A087WWG9 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 0 17767300.0 4455800.0 2262500.0 11049000.0 False True 4314353.067981606 3165928.048781631 8154935.437105048 1.0 0.733812926039165 1.8901873139743268 22.040712814571567 -6.846131017056338 1.2535700123714126 0.8582908943219616 1.9330890050812473 0.9344922360104793 0.12655663097991454 0.16176275779198487 0.4911112806135348 0.07907047100042565 0.18258294153267177 1.4251775841328413e-07 6.846131017056338 1.0747981107592857 SGFLVWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGFLVWR 7 0 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2;A0A087WWG9 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 0 17562900.0 5663400.0 5157400.0 6742100.0 False True 7757312.027630283 4929529.014758886 5149754.837908118 1.0 0.6354687032313133 0.6638581533868342 22.88712540263908 -9.960904714009772 5.222575940952266 1.0000012464573296 0.6496634283081754 0.995099157549348 0.011589944501472854 1.7696769305651155e-07 3.52047147981564e-08 0.011221957558777808 0.003740638501947647 1.0941964111172581e-10 9.960904714009772 -0.3503378181491542 SGFLVWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGFLVWR 7 0 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2;A0A087WWG9 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 0 9821200.0 4455800.0 2146700.0 3218700.0 False True 3705195.1254093307 2135135.301013411 3891715.2884126734 1.0 0.5762544828938078 1.0503401728357658 21.821118090005843 -6.671072427806711 1.9338643731491265 0.7297652703034703 1.0484190176829011 0.28363279383927953 0.17995529411468272 0.45868906147892324 3.3082768022608606 0.07489199119316946 0.19979188780133442 2.1326892123733914e-07 6.671072427806711 0.31865374737943086 SGFLVWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGFLVWR 7 0 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2;A0A087WWG9 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 0 11264000.0 3767100.0 3590400.0 3906500.0 False True 4876585.210642501 3390591.083784744 3195557.084074907 1.0 0.6952797782319539 0.6552858088280765 22.217439835116423 -13.999999999999998 0.28623507104691537 3.5708705365931523 0.6439679113386728 0.9996190439016002 0.003004639085500872 15.745772282754219 0.16958574250372285 23.78412698181361 0.015366185160716415 1.0000000000000041e-14 13.999999999999998 -2.9269026252544794 SGFNLEELEK(ub)NNAQSIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGFNLEELEKNNAQSIR 17 1 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 1 7963900.0 2235200.0 2321300.0 3407400.0 True False 2930368.8457075893 1974971.0883565324 3054834.934088768 1.0 0.6739667230797496 1.0424745466986167 21.48265083751506 -6.6732036244588935 1.9258201396721124 0.792465507588176 1.0410116196219688 0.2932758592913024 0.1383915046698911 0.45387977216564196 3.248250346585285 0.05778673956128079 0.15376062229335466 2.1222491853309787e-07 6.6732036244588935 0.24854611203379273 SGFNLEELEK(ub)NNAQSIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGFNLEELEKNNAQSIR 17 1 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 1 57077900.0 6289300.0 7798600.0 42990000.0 True False 9541327.909419013 6406878.899260097 34493007.65681367 1.0 0.6714871305214604 3.6151160492831242 23.18575863587093 -6.879196542659247 1.0843258839197727 0.7985036534174453 3.8204959095585007 0.9730291223337644 0.2162974687511645 0.1283415904053071 0.2766375853979974 0.15377647874173603 0.37110675316595576 1.3206978089437961e-07 6.879196542659247 3.0219922561410555 up SGFNLEELEK(ub)NNAQSIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGFNLEELEKNNAQSIR 17 1 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 1 7949700.0 2235200.0 2963500.0 2751000.0 True False 3061613.8440087596 2832562.7710160096 2101270.4586234605 1.0 0.9251861649891029 0.6863277231174711 21.54586089903795 -6.950043994836258 0.5583688713708735 1.0031510286230911 0.5969795200454159 0.9992046708386987 0.003772416183752578 0.08346825348696328 0.035890534496071984 0.004051827180799539 0.01984861163037744 1.121904797509087e-07 6.950043994836258 -0.40617150857767526 SGFNLEELEK(ub)NNAQSIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGFNLEELEKNNAQSIR 17 1 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 1 60331000.0 6289300.0 7714700.0 46327000.0 True False 8141622.830637328 7285370.163233681 37895961.35516146 1.0 0.8948302217855725 4.6545955448288625 22.95688495796338 -6.90046348513937 0.9583150543706688 0.8456644696767326 5.0530074043895805 0.9867960096187788 0.20087278429876662 0.11106552813760143 0.17549420456618525 0.1570682174642406 0.4096313761989142 1.2575825856729168e-07 6.90046348513937 4.207342934712848 up SGGASHSELIHNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGGASHSELIHNLR 14 0 A0A0A0MRJ6;P22061;P22061-2;F6S8N6;A0A3F2YNX8;F8WDT3;F8WAV5;F8WAX2;H7C4X2 A0A0A0MRJ6 PCMT1 Protein-L-isoaspartate O-methyltransferase;Protein-L-isoaspartate(D-aspartate) O-methyltransferase 0 7451110.0 1335100.0 915910.0 5200100.0 False True 1292717.9812967924 1281637.6394075532 3838037.8103439235 1.0 0.9914286471995045 2.968967606139267 20.301976141175917 -6.9059243505098475 0.9230511834773629 0.9306032715370214 3.2034400562979 0.989290299778036 0.09626497589796582 0.10717498450315889 0.1538464253066776 0.07725848486519717 0.20769896941783483 1.2418686090865393e-07 6.9059243505098475 2.272836784760879 up SGGCGVSAGNGK(ub)GVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGGCGVSAGNGKGVR 15 1 Q9NV58-2;Q9NV58-3;Q9NV58 Q9NV58-2 RNF19A E3 ubiquitin-protein ligase RNF19A 1 15155400.0 5455600.0 6434900.0 3264900.0 True False 7152344.432105562 5474838.003043738 2927079.467132251 1.0 0.7654606199427694 0.4092475544093106 22.769984782708615 -6.965049647935548 0.35719928729720957 1.0316938582143846 0.1308602326505881 0.9999141646587656 0.00225014538693335 0.07794411953605039 0.01480056254245976 0.004807309555018256 0.030476863486047223 1.0838030081004204e-07 6.965049647935548 -0.9008336255637965 down SGGCGVSAGNGK(ub)GVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGGCGVSAGNGKGVR 15 1 Q9NV58-2;Q9NV58-3;Q9NV58 Q9NV58-2 RNF19A E3 ubiquitin-protein ligase RNF19A 1 14592300.0 6240900.0 3566500.0 4784900.0 True False 9467901.570905056 2930030.209808313 3839162.4177038283 1.0 0.3094698638199114 0.40549243028694004 23.174613277096608 -10.774507060003447 7.138094936730784 1.0157868637987806 0.3574811470534257 0.9835251447086046 0.03920104860611712 0.009453846581049207 0.00029864731619980443 0.03643461115983985 0.012652084033779923 1.6807106034202986e-11 10.774507060003447 -0.6583057167453549 SGGCGVSAGNGK(ub)GVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGGCGVSAGNGKGVR 15 1 Q9NV58-2;Q9NV58-3;Q9NV58 Q9NV58-2 RNF19A E3 ubiquitin-protein ligase RNF19A 1 14830000.0 5455600.0 5143700.0 4230700.0 True False 7472682.752046445 4916434.326058725 3231495.794001552 1.0 0.6579209220025198 0.43244118628167166 22.833194844231507 -8.360656910858042 0.1478247393420672 1.4069080172688182 1.877982595017881e-12 0.9999202273198424 0.00208398375053865 0.10372843507335992 0.03326838737980941 0.14556597282792713 0.13878986871444693 4.358560604917289e-09 8.360656910858042 -1.4069080172669401 down SGGFQSMGLSYPVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGGFQSMGLSYPVFK 15 0 Q8TDD1;Q8TDD1-2;F8VRX4 Q8TDD1 DDX54 ATP-dependent RNA helicase DDX54 0 5121400.0 1362700.0 1629100.0 2129600.0 False True 1786512.896405571 1386044.6301820644 1909249.420565664 1.0 0.7758380210804854 1.0687017286060665 20.76871489775237 -6.702204006837999 1.8233788211646256 0.8611037556097539 1.0678570646285666 0.42790513625000814 0.09458405953815298 0.3909395160495227 2.528508889982296 0.04136289221957382 0.10607143335609236 1.985162182056104e-07 6.702204006837999 0.20675330901881261 SGGFQSMGLSYPVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGGFQSMGLSYPVFK 15 0 Q8TDD1;Q8TDD1-2;F8VRX4 Q8TDD1 DDX54 ATP-dependent RNA helicase DDX54 0 4288400.0 1362700.0 1134700.0 1791000.0 False True 1866527.0155828276 1084565.2020488826 1368002.6868028396 1.0 0.5810605434554744 0.7329134137261214 20.831924959275263 -10.069324083320769 5.669724508003576 1.0000018139885989 0.6569869785907245 0.8718476267353991 0.06199367469028166 1.4214946636442834e-06 2.334053090283774e-07 0.06002543445830323 0.020008372470434015 8.524637430803865e-11 10.069324083320769 -0.34301483539787436 SGGGGDIHQGFQSLLTEVNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGGGGDIHQGFQSLLTEVNK 20 0 A0A2R8YD12;A0A024QZX5;A0A087X1N8;P35237;A0A2R8Y6A7 A0A2R8YD12 SERPINB6 Serpin B6 0 6372450.0 1924800.0 932250.0 3515400.0 False True 1863698.277582254 1304502.2866195252 2594611.2802605797 1.0 0.6999535827826353 1.3921841917601208 20.829736883892707 -6.7888952370700535 1.500655048327458 0.8320624741816735 1.3993328847552784 0.7977485233221693 0.12746753969088645 0.23700462951851206 1.054400586541392 0.06686168933173876 0.15667248942483392 1.6259409269596448e-07 6.7888952370700535 0.5672704105736049 SGGGGGGGGSSWGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGGGGGGGGSSWGGR 15 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 5952440.0 829240.0 2753400.0 2369800.0 False True 1087141.6703715825 2342603.4526691376 2124595.8287267615 1.0 2.154828130052674 1.9542952741389994 20.052108526087405 -10.148980991958094 4.51320809327465 0.9998478590720228 2.0545617021211715 0.9735961532684627 0.08186719569474502 4727175.1543500535 10630151.45563336 4304.780390641008 0.02802531966422481 7.09608825183034e-11 10.148980991958094 1.0547138430491487 SGGGGGGGGSSWGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGGGGGGGGSSWGGR 15 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 2077080.0 697460.0 454840.0 924780.0 False True 675319.5140703027 636459.9839592658 682552.3751946791 1.0 0.942457563714068 1.0107102800580756 19.36521072074864 -13.74714095540677 8.282335583539602 0.9726548710427665 0.9789255296974646 0.0 0.030464822320095584 0.0 0.0 0.0 0.009000706130288175 1.7900247860446017e-14 13.74714095540677 0.0062706586546981136 SGGGGGGGGSSWGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGGGGGGGGSSWGGR 15 0 Q13151 Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0 4593440.0 829240.0 1677200.0 2087000.0 False True 1135832.4373683892 1603095.7582412858 1594093.583114197 1.0 1.4113840259356383 1.4034584069526606 20.115318587610297 -10.20356880802803 5.026148162602339 0.9999595379117251 1.4074212164445408 0.9997162613480662 0.003235620402066861 2275366.9710570974 0.06732592910813623 1065.5326101943451 0.0011076389258726034 6.257937076022774e-11 10.20356880802803 0.4074616785328157 SGGIVISPFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGGIVISPFR 10 0 Q16204 Q16204 CCDC6 Coiled-coil domain-containing protein 6 0 24751300.0 4861600.0 6242700.0 13647000.0 False True 6373604.6798013635 5311313.493854005 12234939.351267654 1.0 0.8333296087041806 1.9196263285737645 22.603678108650655 -6.867759556319545 1.145942185984368 0.9069087365739356 1.980577816015193 0.9623923018341795 0.09263345785459638 0.13901791556723353 0.34260602956232933 0.06281890895853398 0.14816833286178438 1.3559399099085078e-07 6.867759556319545 1.0736690794412573 SGGLGGSHALLLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGGLGGSHALLLLR 14 0 P42704;B8ZZ38;A0A0C4DG06;C9JCA9 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 102898000.0 26004000.0 36491000.0 40403000.0 False True 34091495.82309422 31046685.040803913 36222485.132942565 1.0 0.9106870875337862 1.062507943943157 25.02290856580779 -6.74730221726094 1.6600376841738984 0.9473129668118389 1.0627449830917808 0.6372075054763089 0.03752577186620822 0.30476796086887176 1.6515934723236732 0.017864612551238796 0.04349046965222679 1.789360238964981e-07 6.74730221726094 0.11543201627994193 SGGLGGSHALLLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGGLGGSHALLLLR 14 0 P42704;B8ZZ38;A0A0C4DG06;C9JCA9 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 57232900.0 17075000.0 6915900.0 33242000.0 False True 16532963.471382456 9677454.935942043 24534922.961376265 1.0 0.5853430301647446 1.484000312699215 23.978842009668806 -6.781233892778915 1.5310035744530217 0.7655886261660636 1.491404375976934 0.7717562607424926 0.1754480152903598 0.24865925980383052 1.151306592081074 0.09025055057844299 0.21274012792473956 1.6548784753469342e-07 6.781233892778915 0.7258157498108704 SGGLGGSHALLLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGGLGGSHALLLLR 14 0 P42704;B8ZZ38;A0A0C4DG06;C9JCA9 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 59522000.0 13652000.0 22900000.0 22970000.0 False True 20711082.0948895 18813316.08148333 18429969.431891356 1.0 0.9083695383606033 0.8898602857857913 24.30389959643475 -13.999999999999991 0.22485134252105382 1.5649920663015873 0.8804084310916748 0.9995031974553557 0.001073297938017762 13.136262903752389 0.15018117821239052 3.304073023472015 0.009925488647506761 1.0000000000000205e-14 13.999999999999991 -0.6845836352099125 SGGLGGSHALLLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGGLGGSHALLLLR 14 0 P42704;B8ZZ38;A0A0C4DG06;C9JCA9 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 115795000.0 26004000.0 44170000.0 45621000.0 False True 35618381.53167673 42218423.34934274 34846259.39398793 1.0 1.185298756817357 0.9783223688307644 25.08611862733068 -6.670673636293716 1.9347794287459157 1.118205991631121 0.9791529260704491 0.2821007043653927 0.07869853068729764 0.45958629332717216 3.3173583417721075 0.03273709234788133 0.08739511144361284 2.1346484566152705e-07 6.670673636293716 -0.13905306556067198 SGGLGGSHALLLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGGLGGSHALLLLR 14 0 P42704;B8ZZ38;A0A0C4DG06;C9JCA9 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 41260200.0 17075000.0 9802200.0 14383000.0 False True 14198619.05075729 9749393.603015635 17390418.800521813 1.0 0.6866437903688701 1.2247964917119378 23.759247285103083 -6.748898054607731 1.6543357556286955 0.8154954914315709 1.2257499618601742 0.6440498377301702 0.13166667723524153 0.3019694777648146 1.6257467434848303 0.06288646936150924 0.15282369694646655 1.7827972084792895e-07 6.748898054607731 0.4102544704286033 SGGLGGSHALLLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGGLGGSHALLLLR 14 0 P42704;B8ZZ38;A0A0C4DG06;C9JCA9 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 67633000.0 13652000.0 33961000.0 20020000.0 False True 17672783.121151946 32071040.495881744 16376565.422546957 1.0 1.814713634860206 0.9266545801123088 24.0750259185272 -6.665416476813424 1.9534271344866403 1.5220506416607817 0.9302892197412869 0.2590244854857081 0.3464397143724821 0.47170445907349107 3.4655330925576795 0.14299701286386576 0.38437741906502365 2.160645528535051e-07 6.665416476813424 -0.5917614219194949 SGGMSNELNNIISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGGMSNELNNIISR 14 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 14875200.0 1490300.0 8731300.0 4653600.0 False True 1953797.7320857283 7428624.074340824 4172090.1124832686 1.0 3.802145919378553 2.1353746316561937 20.897849688615494 -10.156004035494522 6.040864117546336 0.9999843062304432 2.9687602755173947 0.6503807758919415 0.6804565288069807 0.00014382511429233825 2.0094304070953323e-05 0.6588544214324965 0.2196164003239509 6.982259160832682e-11 10.156004035494522 1.9687759692869515 SGGMSNELNNIISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGGMSNELNNIISR 14 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 20397800.0 6911300.0 2793500.0 10693000.0 False True 6691904.564554346 3908959.1179100494 7892182.516876135 1.0 0.5841325261294085 1.1793626822891972 22.67398544010003 -6.718871407370985 1.7632148086952828 0.7466806015345591 1.1783833491318059 0.5071600478128728 0.17502456657431273 0.3575656642170648 2.1718720091673958 0.07883288568158674 0.19817527667971732 1.9104188411947797e-07 6.718871407370985 0.4317027475972468 SGGMSNELNNIISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGGMSNELNNIISR 14 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 20311900.0 1490300.0 10427000.0 8394600.0 False True 2041304.18384317 9966300.662522 6411968.37221392 1.0 4.882320205584653 3.1411136189130255 20.961059750138386 -9.383939344868832 8.900014575620672 0.9999999999999835 4.011716912249007 0.7995599129499411 0.7108446123537027 0.0 0.0 0.6882723414745516 0.22942411211550762 4.131051937202313e-10 9.383939344868832 3.0117169122490233 SGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGK 34 0 Q12906-7;Q12906;K7ELV3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 18043500.0 4302800.0 7490800.0 6249900.0 False True 5641012.46837448 6373201.838909706 5603220.301274114 1.0 1.129797509691769 0.9933004638241377 22.427522695070735 -6.657636414905799 1.9821581789050833 1.0837147708137378 0.993881506494647 0.22531406251653308 0.05529690257800924 0.4900257618087654 3.698835733865399 0.022563247603228104 0.061250929263658875 2.199700659893306e-07 6.657636414905799 -0.08983326431909078 SGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGK 34 0 Q12906-7;Q12906;K7ELV3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 17966800.0 5285300.0 2331500.0 10350000.0 False True 5117521.044526956 3262480.108611878 7639024.506655564 1.0 0.6375118109384246 1.4927197055350234 22.287013699308034 -6.791543776948407 1.49014533422767 0.797812071028482 1.5022079469817349 0.806294033687377 0.15425513230829166 0.23305641473380553 1.0223145456584608 0.08147255425650606 0.19053607898356495 1.6160553192795526e-07 6.791543776948407 0.7043958759532529 SGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGK 34 0 Q12906-7;Q12906;K7ELV3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 36137800.0 5379200.0 26283000.0 4475600.0 False True 8160639.672196708 21592593.29998371 3590995.698274838 1.0 2.645943720998938 0.4400385070926924 22.960250811684688 -6.7069240840198034 1.8058572660753296 2.015032683184672 0.4456060863450151 0.45062116618205195 0.6939330565915034 0.3812942387660809 2.4218509425099097 0.306000624157948 0.7803897757873495 1.9637035081090562e-07 6.7069240840198034 -1.569426596839657 SGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGK 34 0 Q12906-7;Q12906;K7ELV3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 17623400.0 4302800.0 7093900.0 6226700.0 False True 5893661.438797832 6780468.041609746 4756081.702911922 1.0 1.1504678563607487 0.8069825103292751 22.490732756593626 -6.787611568995998 1.5056776578301032 1.0843565628749485 0.803555988258229 0.7935704378203458 0.06387434080002626 0.23891858249452716 1.0700380636840252 0.0333949547254031 0.07833015128879421 1.6307539194473355e-07 6.787611568995998 -0.2808005746167195 SGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGK 34 0 Q12906-7;Q12906;K7ELV3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 9773900.0 5285300.0 2710000.0 1778600.0 False True 4394961.128490048 2695400.692107114 2150497.0366827548 1.0 0.6132934088163727 0.4893096830236559 22.06741897474231 -13.999999999999998 0.15914102149579393 2.901058948437109 0.3662649830051569 0.9995386531821153 0.00467146894951387 12.004080156310003 0.1260366975222535 7.044490235842883 0.11202463376631365 1.0000000000000041e-14 13.999999999999998 -2.5347939654319522 SGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGK 34 0 Q12906-7;Q12906;K7ELV3 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 14904000.0 5379200.0 4142000.0 5382800.0 False True 6963480.4398842985 3911494.058889377 4403185.632192095 1.0 0.56171537963771 0.6323254111510445 22.731377133777137 -10.683143462177554 6.725338122383339 1.0029806824667462 0.5970203953943952 0.977491783990681 0.02882642465491828 0.0012950838620599935 6.1016303624227126e-05 0.02805768578884364 0.00930368855160012 2.0742282164350768e-11 10.683143462177554 -0.405960287072351 SGGPHGAGVLGLHLEGPFISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGGPHGAGVLGLHLEGPFISR 21 0 Q9Y303-2;Q9Y303-3;Q9Y303;A0A3B3IU33;H3BQ15;H3BSD5 Q9Y303-2 AMDHD2 Putative N-acetylglucosamine-6-phosphate deacetylase 0 5542300.0 1600800.0 2183700.0 1757800.0 False True 2098664.302169252 1857900.4719959304 1575919.7180082288 1.0 0.8852775882619912 0.7509155782462701 21.00103998401134 -6.969044301656954 0.28010370784808647 1.029563677135295 0.6025347939496791 0.9999739221030494 0.0005197924451391211 0.07661432537673206 0.010136962952542794 0.002480344299324998 0.012331108034383876 1.0738798620572109e-07 6.969044301656954 -0.4270288831856158 SGGPHGAGVLGLHLEGPFISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGGPHGAGVLGLHLEGPFISR 21 0 Q9Y303-2;Q9Y303-3;Q9Y303;A0A3B3IU33;H3BQ15;H3BSD5 Q9Y303-2 AMDHD2 Putative N-acetylglucosamine-6-phosphate deacetylase 0 8323600.0 3239500.0 2416000.0 2668100.0 False True 3136663.845712645 3380721.3992735576 1969244.5687157202 1.0 1.077808004161652 0.6278149861061414 21.580799494071748 -6.862316113655436 1.1738919880285927 1.042507613852043 0.6050312834541001 0.956399096500826 0.04100480039124617 0.14443976259605673 0.3768961096607573 0.027216248915366312 0.06370946341277263 1.37304220317658e-07 6.862316113655436 -0.437476330397943 SGGPHGAGVLGLHLEGPFISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGGPHGAGVLGLHLEGPFISR 21 0 Q9Y303-2;Q9Y303-3;Q9Y303;A0A3B3IU33;H3BQ15;H3BSD5 Q9Y303-2 AMDHD2 Putative N-acetylglucosamine-6-phosphate deacetylase 0 10235300.0 1600800.0 4583200.0 4051300.0 False True 2192659.0199933904 4380699.069384368 3094466.379142573 1.0 1.9978934387151421 1.411284814887406 21.06425004553423 -10.6747154406384 6.571211410209488 0.9948663971547602 1.704589126801251 0.6579554032409166 0.23948196784903258 0.018033400863424285 0.0008926783900508909 0.23216335503735122 0.07729247276635691 2.1148742984333407e-11 10.6747154406384 0.7097227296464907 SGGPHGAGVLGLHLEGPFISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGGPHGAGVLGLHLEGPFISR 21 0 Q9Y303-2;Q9Y303-3;Q9Y303;A0A3B3IU33;H3BQ15;H3BSD5 Q9Y303-2 AMDHD2 Putative N-acetylglucosamine-6-phosphate deacetylase 0 6069400.0 3239500.0 1127100.0 1702800.0 False True 2693787.7841832037 1121028.0885881654 2058847.6071423572 1.0 0.4161530819800928 0.764294655737564 21.361204769506024 -10.381141078844875 5.99871357366778 1.0000794674444975 0.5902238688588571 0.6487810809711363 0.14212820232588735 0.00015108219851967997 1.558624602285553e-05 0.13764156066879438 0.04587168005287986 4.1577552551916666e-11 10.381141078844875 -0.40985559858564036 SGGPVVVLVQLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGGPVVVLVQLER 13 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 3801180.0 1074500.0 1727000.0 999680.0 False True 1408679.9054728004 1469338.3317932729 896242.7032076847 1.0 1.0430604753321255 0.6362287839314891 20.42591239442074 -6.880732470790882 1.0756742941180744 1.0269574713909764 0.606985164807813 0.9742728101521043 0.02926949223388196 0.12698464887770003 0.2683650628222446 0.020946300448518453 0.05075042760893643 1.3160352718152149e-07 6.880732470790882 -0.4199723065831634 SGGPVVVLVQLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGGPVVVLVQLER 13 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 5151300.0 1634100.0 1494900.0 2022300.0 False True 1582226.389961118 2091821.3658005132 1492598.962300441 1.0 1.3220746279247169 0.9433536008314969 20.59352460927823 -6.681426237649273 1.8970127445225347 1.2035192617142771 0.94478469194669 0.3306198907490947 0.1364604258621221 0.43533801025229946 3.0302019008196663 0.05769763308972914 0.15188541545326747 2.0824460663411043e-07 6.681426237649273 -0.25873456976758713 SGGPVVVLVQLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGGPVVVLVQLER 13 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 26018200.0 7124500.0 8901700.0 9992000.0 False True 10808387.37071786 7313122.085700452 8017076.820350821 1.0 0.6766154686047986 0.7417458817279928 23.36564795085295 -10.787067581933082 7.07691192798831 1.009051472534689 0.7091806751671679 0.9637468781879124 0.026589379814749205 0.003832224257781752 0.00011530508207891964 0.025981942045056213 0.008581685434042271 1.632797843305403e-11 10.787067581933082 -0.2998707973675212 SGGPVVVLVQLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGGPVVVLVQLER 13 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 5290500.0 1074500.0 1732100.0 2483900.0 False True 1471771.6872706742 1655570.0947112644 1897253.977526286 1.0 1.1248824182651829 1.2890953086919663 20.489122455943633 -6.967352877714809 0.315067370171174 0.9761688134781802 1.4430673596177508 0.9999537537183462 0.0008050600043150424 0.07717134805391927 0.012090296871535096 0.0025408579494797185 0.01450916616504137 1.0780704006750139e-07 6.967352877714809 0.4668985461395706 SGGPVVVLVQLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGGPVVVLVQLER 13 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 4327900.0 1634100.0 1301000.0 1392800.0 False True 1358826.5529043928 1293991.2547717178 1684028.0404204114 1.0 0.9522858174988601 1.2393252375153576 20.373929884712506 -6.8641847285105735 1.1643192400327949 0.9737610189314343 1.2543843217607287 0.9585321364930547 0.02557374741467448 0.1425580286689082 0.36486580730048257 0.017098906169821012 0.040123911760349996 1.3671471815906344e-07 6.8641847285105735 0.2806233028292944 SGGPVVVLVQLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGGPVVVLVQLER 13 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 22858700.0 7124500.0 8033500.0 7700700.0 False True 9222805.694890643 7586428.662985958 6299251.615854516 1.0 0.8225727521494653 0.683008167389263 23.1367742729454 -6.973823205638376 0.1392906156425066 1.188841552590989 0.3131010715753639 0.9999989462322701 0.00013303518521426378 0.0750804101464502 0.004215517236279534 0.007947442193375249 0.018234520250445398 1.0621278445210023e-07 6.973823205638376 -0.8757404810156251 SGGSGGCSGAGGASNCGTGSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGGSGGCSGAGGASNCGTGSGR 22 0 A0A087WUC6;E9PI68;Q15005;E9PL01 A0A087WUC6 SPCS2 Signal peptidase complex subunit 2 0 9818560.0 638260.0 5797300.0 3383000.0 False True 836765.0409186315 4932365.437698402 3032959.61202744 1.0 5.894564419521482 3.624625150087228 19.674463053140602 -10.436449396631259 7.926969106945782 0.999871798598603 4.759594784804356 0.7852956457623519 0.9266988262033244 0.0020996781129289667 0.00014927196437076922 0.8972979347010239 0.2990907600696199 3.6605859069401995e-11 10.436449396631259 3.7597229862057526 SGGSGGCSGAGGASNCGTGSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGGSGGCSGAGGASNCGTGSGR 22 0 A0A087WUC6;E9PI68;Q15005;E9PL01 A0A087WUC6 SPCS2 Signal peptidase complex subunit 2 0 6166160.0 638260.0 3297000.0 2230900.0 False True 874241.9703279482 3151327.638278985 1704007.366827728 1.0 3.6046400713258477 1.949125556381737 19.737673114663494 -10.368095616390223 6.159221388501539 0.9997721661332374 2.776882813853789 0.6056777433974678 0.6758609705640464 0.002114734349229116 0.00021696041669142568 0.6544765774746366 0.21813319027884417 4.284541794517745e-11 10.368095616390223 1.7771106477205514 SGGTALHVAAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGGTALHVAAAK 12 0 O14974-5;O14974-2;O14974;O14974-4;O14974-3;F8VZN8;F8VW28;H0YHL8 O14974-5 PPP1R12A Protein phosphatase 1 regulatory subunit 12A 0 2299200.0 642000.0 435900.0 1221300.0 False True 879364.7493976484 416640.49667146243 932854.093463042 1.0 0.47379713248325556 1.0608272552453724 19.746102175638153 -6.670450643362575 1.9361287003319576 0.6642519824429334 1.0584414075560584 0.28092921557203343 0.2234970991940201 0.46006064217854103 3.325368814079913 0.0929252752032125 0.24809529879510153 2.1357447950757821e-07 6.670450643362575 0.39418942511312505 SGGTEGLLAEK(ub)LEALITQTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGGTEGLLAEKLEALITQTR 20 1 Q9UHB9-4;Q9UHB9 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 1 55632000.0 18239000.0 15491000.0 21902000.0 True False 27669896.44950842 12726510.018264573 17573060.100012377 1.0 0.4599406449347471 0.6350967063458084 24.721813909096873 -10.582641545050041 6.992692134599053 1.0005459356734978 0.5475186756402787 0.8989689258453716 0.07150716263544916 0.0006092946507591189 3.636570094906507e-05 0.06931467966926153 0.02307883750180332 2.614318251916273e-11 10.582641545050041 -0.45302726003321914 SGGTEGLLAEK(ub)LEALITQTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGGTEGLLAEKLEALITQTR 20 1 Q9UHB9-4;Q9UHB9 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 1 48446000.0 18239000.0 12723000.0 17484000.0 True False 23610745.04443963 12014953.865584146 14302091.400989555 1.0 0.508876523928824 0.6057450272776429 24.492940231189323 -9.9364554709918 5.705735446297533 1.0000003782641953 0.5573107756028233 0.9653338134792018 0.039546400893563136 1.9029810604955017e-07 3.540014852723778e-08 0.03829067053690924 0.012763546005032472 1.1575627130317149e-10 9.9364554709918 -0.44268960266137203 SGGVGGSNTNWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGGVGGSNTNWK 12 0 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 0 3304840.0 493340.0 1508500.0 1303000.0 False True 646773.5175113555 1283437.6800869456 1168178.059258576 1.0 1.9843695595721609 1.8061624782558698 19.302901082535318 -10.204170954288083 4.660001304288878 0.9998248590578629 1.895266018919732 0.9711404842802746 0.07275273631549738 51164512.95055439 30.861836745791816 96151.98447855648 0.024905196747205316 6.249266502292551e-11 10.204170954288083 0.895441159861869 SGGVGGSNTNWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGGVGGSNTNWK 12 0 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 0 3733680.0 953980.0 741000.0 2038700.0 False True 923696.4270822499 1036885.1642639528 1504703.3103109843 1.0 1.122538892500906 1.629001981813446 19.817059262113407 -6.944123901595702 0.6200188047855587 0.994457040190335 1.7839158820165018 0.9986556167606444 0.009982896374609525 0.08593477121084933 0.046414753581696284 0.010053373916401038 0.04286235423399916 1.1373027739146383e-07 6.944123901595702 0.7894588418261668 SGGVGGSNTNWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGGVGGSNTNWK 12 0 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 0 4040540.0 493340.0 1877900.0 1669300.0 False True 675741.1300122052 1794928.1686151407 1275045.720312666 1.0 2.6562363735099574 1.8868848789619126 19.36611114405821 -10.575477471759742 7.218082942179066 0.998903273715924 2.271560626235935 0.78458469505335 0.31408643241505735 0.005546267403906609 0.0003261968805410131 0.3042737461856138 0.10137096016776816 2.6578014146167975e-11 10.575477471759742 1.272657352520011 SGGVGGSNTNWK(ub)TLYEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGGVGGSNTNWKTLYEVK 18 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 11224400.0 1871300.0 3189500.0 6163600.0 True False 1811896.6057978321 4463083.983022771 4549168.255963498 1.0 2.4632111836522492 2.510721771544113 20.78906920100045 -10.717048809470725 0.62648164357579 7.732943352123996e-16 2.504284866024895 0.9999025518696912 0.006922257079699417 2.28489386758626 0.31007999293679106 3.502437250627739 0.007990213967609188 1.9184531175221566e-11 10.717048809470725 2.504284866024894 SGGVGGSNTNWK(ub)TLYEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGGVGGSNTNWKTLYEVK 18 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 20536000.0 4702100.0 4520900.0 11313000.0 True False 7133429.469556096 3714110.07304708 9076980.591335963 1.0 0.5206626194172218 1.2724567657218053 22.766164403245387 -6.734424093327296 1.7068163478970024 0.712980180841242 1.2724114614820157 0.5798319676362289 0.20144104788929784 0.32797624179410584 1.8737058981577281 0.09344792428941946 0.23075740049698154 1.843214620769228e-07 6.734424093327296 0.5594312806407736 SGGVGGSNTNWK(ub)TLYEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGGVGGSNTNWKTLYEVK 18 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 8619500.0 1871300.0 3365000.0 3383200.0 True False 1556068.8626460976 3346872.0770997936 4090611.4778506155 1.0 2.150850876489124 2.6288113437952383 20.569474476434728 -9.754316258024955 0.23224063131957853 2.1175459721887985e-17 2.9576359007814217 0.9992137916389178 0.019168079081774616 1.1862599160279712 0.09949723684054938 1.0400759514284699 0.232950348637344 1.7606934231154627e-10 9.754316258024955 2.9576359007814217 SGGVNQYVVQEVLSIK(ub)HLPPQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGGVNQYVVQEVLSIKHLPPQLR 23 1 Q15021;E7EN77;F5GZK7;F5H431 Q15021 NCAPD2 Condensin complex subunit 1 1 15544700.0 2681000.0 2851700.0 10012000.0 True False 2595893.1225052034 3990398.6814190466 7389556.846438215 1.0 1.5371968309573762 2.8466337008924385 21.307799555586552 -6.956002004520948 0.48853603486317043 0.9709600898427306 3.4682583358807393 0.9995919651051237 0.015665954724767454 0.08116151412809681 0.026653406008664695 0.018794027359041236 0.10799878081111741 1.1066186762787902e-07 6.956002004520948 2.4972982460380084 SGGVNQYVVQEVLSIK(ub)HLPPQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGGVNQYVVQEVLSIKHLPPQLR 23 1 Q15021;E7EN77;F5GZK7;F5H431 Q15021 NCAPD2 Condensin complex subunit 1 1 48983500.0 4966500.0 10178000.0 33839000.0 True False 7534543.599785273 8361656.378923045 27150706.8178394 1.0 1.1097760956830012 3.60349720699913 22.845088693454038 -6.91612515581741 0.8529833540472807 0.9369251084369579 3.971837990457695 0.9930347888814284 0.1003381445151835 0.10050566461697173 0.11782958138903048 0.08472219773127351 0.24509431455656625 1.2130392241174035e-07 6.91612515581741 3.0349128820207367 up SGGVNQYVVQEVLSIK(ub)HLPPQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGGVNQYVVQEVLSIKHLPPQLR 23 1 Q15021;E7EN77;F5GZK7;F5H431 Q15021 NCAPD2 Condensin complex subunit 1 1 14290300.0 2681000.0 4495500.0 7113800.0 True False 2229370.288438084 4471281.849213112 8601262.689505113 1.0 2.0056254774731617 3.8581579444710514 21.08820483102083 -6.961620498820185 0.4119657400222997 0.9106759490473791 5.022076688767579 0.9998256458915528 0.01563114098324011 0.07912732589752951 0.01902982738477776 0.023869250621098403 0.15457550322877384 1.0923944906865107e-07 6.961620498820185 4.1114007397202 SGGVNQYVVQEVLSIK(ub)HLPPQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGGVNQYVVQEVLSIKHLPPQLR 23 1 Q15021;E7EN77;F5GZK7;F5H431 Q15021 NCAPD2 Condensin complex subunit 1 1 40074500.0 4966500.0 10353000.0 24755000.0 True False 6429232.154351085 9776846.448981592 20249844.00774976 1.0 1.520686485456114 3.1496520146726 22.616215015546487 -6.950503991397306 0.5532815377175889 0.9778978012006133 3.7693993128215277 0.9992402527014708 0.025238384665887657 0.08328397009846052 0.035129486465606395 0.027279081954934968 0.13522232572619963 1.1207171261027767e-07 6.950503991397306 2.7915015116209143 SGHIQTALYGK(ub)MGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGHIQTALYGKMGR 14 1 P08910;H3BMT2;H3BUZ6 P08910 ABHD2 Abhydrolase domain-containing protein 2 1 4787900.0 916570.0 963930.0 2907400.0 True False 1201632.1460765048 820115.4013697116 2606570.1377501027 1.0 0.6825012164059541 2.1691914170746136 20.196563882798994 -6.8508610802050764 1.2309721684402868 0.8304455562563818 2.2296048493131027 0.9415474219656147 0.15455750246130645 0.15650818428727 0.4559411067230992 0.09822846394090758 0.22742894278302905 1.4097396662882425e-07 6.8508610802050764 1.3991592930567207 up SGHIQTALYGK(ub)MGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGHIQTALYGKMGR 14 1 P08910;H3BMT2;H3BUZ6 P08910 ABHD2 Abhydrolase domain-containing protein 2 1 5989310.0 916570.0 782240.0 4290500.0 True False 1255450.6983729005 747678.0502782388 3277172.2656212114 1.0 0.5955455289859257 2.6103552054003547 20.259773944321886 -6.854487618822853 1.213236133815069 0.7830363809375064 2.6981543992330335 0.9465899676517819 0.2011240689941945 0.15258340410678697 0.4299448369756705 0.12955444403082653 0.30078780185292003 1.3980167704148483e-07 6.854487618822853 1.915118018295527 up SGIGK(ub)SALAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGIGKSALAR 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 18964000.0 6470600.0 7505800.0 4987600.0 True False 8483019.26137954 6385963.897379252 4471530.996437504 1.0 0.7527937519194956 0.5271155067152739 23.016146407008875 -6.972212913378976 0.1983318324857183 1.1372547902948071 0.13643471259466575 0.9999948881320964 0.0004365975071873238 0.07559098960675434 0.006390767399558386 0.007428624374269928 0.024060595937311934 1.0660733493864352e-07 6.972212913378976 -1.0008200777001415 SGIGK(ub)SALAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGIGKSALAR 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 19023200.0 4633700.0 6071800.0 8317700.0 True False 4486605.729859139 8496301.404018715 6139044.844348695 1.0 1.8937035958997592 1.3683049534511775 22.09719297897493 -10.365720249327428 5.1358784974417935 0.9996513027132918 1.6310042746755207 0.6579096568502194 0.21449309759185037 0.0008568619450738112 0.00010582221359573289 0.207793230444227 0.06922734957078035 4.3080402342907847e-11 10.365720249327428 0.6313529719622288 SGIGK(ub)SALAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGIGKSALAR 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 44302700.0 9913600.0 9432100.0 24957000.0 True False 15039655.981240591 7748868.061666341 20024238.01095833 1.0 0.5152290764716781 1.3314292584840475 23.84226823123809 -6.745775587999702 1.665259893037345 0.7135169786436462 1.3325669423239086 0.6307188304286 0.20367585559243753 0.30745508452330683 1.676070912973156 0.09667094618456994 0.23576144156877574 1.7956612551043099e-07 6.745775587999702 0.6190499636802624 SGIGK(ub)SALAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGIGKSALAR 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 18941000.0 6470600.0 5848500.0 6621900.0 True False 8862955.681390077 5590093.931596801 5057943.602311413 1.0 0.6307257006073671 0.5706836166327438 23.079356468531767 -13.999999999999998 0.2556343087791542 3.642851774804745 0.5478033345958925 0.9995535592273423 0.004010708064333978 14.228567644126397 0.15998918047213226 19.37488314734484 0.026867507817438054 1.0000000000000041e-14 13.999999999999998 -3.0950484402088527 SGIGK(ub)SALAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGIGKSALAR 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 23690400.0 4633700.0 11393000.0 7663700.0 True False 3853126.857715607 11331623.64766656 9266144.237054793 1.0 2.9408903641404396 2.40483757198391 21.877598254409207 -10.216574143888762 5.003508059344556 0.9997988216133544 2.672863968063769 0.9284952609316323 0.21884263600182718 0.0004911805255257397 7.690634510234488e-05 0.21191778873121142 0.07063115705547406 6.073315687799933e-11 10.216574143888762 1.6730651464504147 SGIGK(ub)SALAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGIGKSALAR 10 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 37833700.0 9913600.0 7321100.0 20599000.0 True False 12833350.626271019 6913674.349235884 16850193.36358864 1.0 0.5387271454333191 1.3130003110095647 23.61339455333054 -6.745359838455292 1.6673345787832379 0.7272569629069777 1.3139816067082597 0.6286385428786074 0.19380068246411186 0.30820706187133745 1.6843141730676243 0.09188501587173466 0.2241419231722545 1.79738106234881e-07 6.745359838455292 0.586724643801282 SGK(ub)DFVTEALQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGKDFVTEALQSR 13 1 Q15126 Q15126 PMVK Phosphomevalonate kinase 1 7010100.0 2783800.0 2532000.0 1694300.0 True False 3649588.7583575514 2154235.4696586984 1518990.088873219 1.0 0.5902680034087411 0.41620856196324435 21.79930247723362 -13.999999999999982 0.11703329557382022 2.9579377932326865 0.12696020458631788 0.9997076146405847 0.004184526013339113 11.976096562412666 0.10489009720294695 5.476387192197774 0.2566612574714871 1.0000000000000409e-14 13.999999999999982 -2.8309775886463684 SGK(ub)DFVTEALQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGKDFVTEALQSR 13 1 Q15126 Q15126 PMVK Phosphomevalonate kinase 1 7700900.0 1525800.0 1484000.0 4691100.0 True False 1477364.3141806952 2076568.9389577666 3462360.180016612 1.0 1.4055902928110007 2.343606209235357 20.494594204127893 -6.957108232780557 0.474440254391398 0.9762638437700786 2.8116752488155714 0.999647439511406 0.010565538614394096 0.08075082960213055 0.025074848422303307 0.013080284178177057 0.07739775378971386 1.1038035010255831e-07 6.957108232780557 1.8354114050454928 up SGK(ub)DFVTEALQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGKDFVTEALQSR 13 1 Q15126 Q15126 PMVK Phosphomevalonate kinase 1 4632710.0 1525800.0 2205900.0 901010.0 True False 1268770.3044009074 2194016.378863135 1089407.0252004568 1.0 1.7292463192532816 0.8586321900991032 20.27499947956217 -6.684552408462336 1.886292172143743 1.4595145809580237 0.8618636429380765 0.3448755169536678 0.30877030676214773 0.42845601775031905 2.9513773060982955 0.13117981269253498 0.3439000501957323 2.067509870226777e-07 6.684552408462336 -0.5976509380199472 SGK(ub)LGEQCEAVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGKLGEQCEAVVR 13 1 Q9NVH2-3;Q9NVH2-2;Q9NVH2;Q9NVH2-4;A0A087WYC2 Q9NVH2-3 INTS7 Integrator complex subunit 7 1 12479000.0 5056300.0 5246800.0 2175900.0 True False 4204537.482069928 5218534.446991741 2630870.6297751097 1.0 1.2411673030020447 0.6257217686830825 22.003515675625245 -6.800423425164586 1.4541667149869901 1.1329953348226602 0.617137013809905 0.833378912619184 0.1033567416125988 0.22016919592070905 0.9191033289445477 0.0559136050793259 0.13000200090277236 1.5833487182597052e-07 6.800423425164586 -0.5158583210127552 SGK(ub)PAELLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGKPAELLK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 8873700.0 2498900.0 3750500.0 2624300.0 True False 3276082.0993820205 3190940.019334493 2352762.6100631463 1.0 0.974011005382439 0.7181635071071499 21.643540081030558 -6.926452842293554 0.7753538699961988 1.004444734410362 0.6700884848261711 0.9957940031614516 0.00824787099593843 0.0945219779690417 0.08701282313336166 0.007361311066433783 0.023617383173969244 1.1845329820920407e-07 6.926452842293554 -0.33435624958419086 SGK(ub)PAELLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGKPAELLK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 14028400.0 4678100.0 3369400.0 5980900.0 True False 4529596.276162475 4714818.991188883 4414322.866846013 1.0 1.0408916609193546 0.9745510632099593 22.110951037623394 -6.739942530549946 1.6868096367038317 1.024332000352311 0.9745119673046881 0.6047110505619808 0.017180990907382558 0.3179278168300226 1.776166460575011 0.008057634772402874 0.01977470287614289 1.8199416724621777e-07 6.739942530549946 -0.04982003304762295 SGK(ub)PAELLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGKPAELLK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 22227200.0 7553600.0 4461600.0 10212000.0 True False 11459363.442129893 3665392.6213600943 8193593.723921388 1.0 0.3198600550432343 0.7150129904945651 23.450023570052515 -10.769534872248295 6.963239711573838 1.0119886565732836 0.5174365227694403 0.6653796728020842 0.16132051036978304 0.02967365153126756 0.0009821193679620589 0.1543735575003839 0.05206597083865421 1.7000634393252465e-11 10.769534872248295 -0.49455213380384333 SGK(ub)PAELLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGKPAELLK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 7559800.0 2498900.0 2598900.0 2462000.0 True False 3422810.860233306 2484072.004586976 1880526.306481627 1.0 0.7257403654543905 0.5494099391613612 21.70675014255345 -8.814048651927365 0.10010862772161307 1.6039930419373518 1.3112922911876709e-11 0.9999705879218147 0.0010054350124537547 0.3336513900882478 0.029134781230515324 0.25080477370623244 0.19642038619415475 1.5344450766498255e-09 8.814048651927365 -1.603993041924239 SGK(ub)PAELLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGKPAELLK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 15569100.0 4678100.0 7514600.0 3376400.0 True False 3890047.4249691176 7474117.358268686 4082389.6292902576 1.0 1.9213435060699862 1.049444693935233 21.89135631305767 -10.344247929263613 4.8001345495001075 0.9996545411509749 1.4853941000029316 0.29240286169094076 0.35595119951259396 0.0013168744580271375 0.00017989988604654873 0.34488844382548217 0.11488275564774499 4.5263910432247426e-11 10.344247929263613 0.48573955885195674 SGK(ub)PAELLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGKPAELLK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 17029800.0 7553600.0 4228400.0 5247800.0 True False 9778284.103716183 3993085.822937675 4292754.246975118 1.0 0.4083626309671371 0.4390089510023216 23.221149892144965 -9.946686442991794 5.154690915241076 1.0000018033911202 0.4236857910168153 0.9978836899593654 0.012511307786642695 17153506.651642475 1.9566065577743061 436.4517025390752 0.004282953433087392 1.1306119124742332e-10 9.946686442991794 -0.576316012374305 SGK(ub)QSIAIDDCTFHQCVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGKQSIAIDDCTFHQCVR 18 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2;C9JJ47 E9PFW3 AP2M1 AP-2 complex subunit mu 1 53803700.0 24582600.0 21267700.0 7953400.0 True False 32228026.658237044 18094642.060845308 7130458.462399967 1.0 0.5614567175561326 0.22125023471077213 24.94181251821454 -7.959682789733324 0.29663351293637663 1.1242946867002606 2.042656330628442e-12 0.9992654100813935 0.008639643073320342 0.10349827753671792 0.05487612255099489 0.05553039565235022 0.0891916753086773 1.0972793603503966e-08 7.959682789733324 -1.124294686698218 down SGK(ub)QSIAIDDCTFHQCVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGKQSIAIDDCTFHQCVR 18 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2;C9JJ47 E9PFW3 AP2M1 AP-2 complex subunit mu 1 102560000.0 63127000.0 24233000.0 15200000.0 True False 95768274.20188166 19908431.8167068 12195713.337603334 1.0 0.20788128409560122 0.1273460698675064 26.513044468062848 -13.999999999999998 0.32307533587752446 9.272023378345633 0.11190041549342447 0.9997002934662562 0.006816882943640913 18.25519091146955 0.18141049454095234 102.23654147708734 0.026494825777815926 1.0000000000000041e-14 13.999999999999998 -9.160122962852208 SGK(ub)QSIAIDDCTFHQCVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGKQSIAIDDCTFHQCVR 18 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2;C9JJ47 E9PFW3 AP2M1 AP-2 complex subunit mu 1 101278400.0 63127000.0 28183400.0 9968000.0 True False 81719145.91920291 26614969.01480029 8153926.2803170765 1.0 0.32568829146984674 0.09977987641205893 26.284170790155297 -10.125086666610017 0.266530259238053 1.5839731493053035 6.153189781628835e-22 0.9989953877729432 0.012120676277341608 1.6281417744294424 0.12531424996598456 0.7842183918795333 0.09260560157676442 7.497445774410972e-11 10.125086666610017 -1.5839731493053035 SGK(ub)SPILVATAVAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGKSPILVATAVAAR 15 1 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 1 7833290.0 971190.0 3374100.0 3488000.0 True False 940360.105052529 4721395.725699051 2574388.162242959 1.0 5.0208379750811645 2.737662038628438 19.842853808128115 -10.303596488870657 7.354604362020541 0.999978247605296 3.879250006854801 0.679528735466032 0.9321026728850551 0.00033245782336591297 3.148468716064974e-05 0.9025112136211617 0.3008348440866034 4.970539290790104e-11 10.303596488870657 2.879271759249505 SGK(ub)YDLDFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGKYDLDFK 9 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 24082500.0 8491900.0 5073600.0 10517000.0 True False 8222329.28273105 7099514.938474472 7762282.196762946 1.0 0.8634432767592063 0.9440490559123779 22.97111571853698 -10.208819174340894 4.647318410779739 1.0000202557726328 0.9037461663351681 0.6553226504221417 0.03290717154292473 6.907723443355327e-06 1.175982871089663e-06 0.03186893560459746 0.010620743946076538 6.182737750209615e-11 10.208819174340894 -0.09627408943746463 SGK(ub)YDLDFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGKYDLDFK 9 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 117226000.0 12817000.0 17094000.0 87315000.0 True False 19444326.048212603 14043442.143968401 70057151.97847594 1.0 0.7222385650779256 3.602961182854464 24.212845895190824 -6.8832354690102155 1.061545710318129 0.8191989222985561 3.8202558890189118 0.976204711427107 0.20014586328511283 0.12480464766370372 0.25527121286498367 0.14478440806261034 0.3532026589908009 1.3084722934070356e-07 6.8832354690102155 3.0010569667203555 up SGK(ub)YDLDFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGKYDLDFK 9 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 25584700.0 8491900.0 8404000.0 8688800.0 True False 7061391.104956126 8358725.983936618 10505587.907527918 1.0 1.1837222807372816 1.487750466073808 22.751520993971255 -6.963573616372448 0.3817442832533248 0.9795214654104728 1.7027322843107902 0.999880651293951 0.0021972982338927145 0.07844842006749503 0.01658774547766958 0.00394981896759004 0.025668842883534035 1.0874927833215065e-07 6.963573616372448 0.7232108189003174 SGK(ub)YDLDFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGKYDLDFK 9 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 124501000.0 12817000.0 17561000.0 94123000.0 True False 16591859.160841217 16583714.912640352 76993579.7835358 1.0 0.9995091419158085 4.640443185851644 23.983972217283274 -6.906860180954847 0.9168241794991236 0.8757719769679253 5.0807319263343285 0.9896824333953402 0.17432750803283092 0.10653188580478916 0.1502901785554618 0.14054458900081476 0.3800365597238514 1.2391954754127323e-07 6.906860180954847 4.204959949366403 up SGK(ub)YDLDFKSPDDPSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGKYDLDFKSPDDPSR 16 2 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 17804800.0 1711100.0 2563700.0 13530000.0 True False 2215052.6808235473 2421027.841326582 11067678.829523493 1.0 1.092988831501043 4.996575894262062 21.078909580275614 -6.912028512145363 0.8818208112323133 0.886753664025661 5.523542529986882 0.991664547765509 0.17004137782056125 0.10309145547697228 0.1316090057544208 0.14062691837049648 0.3938657099127009 1.2245358038411912e-07 6.912028512145363 4.636788865961221 up SGK(ub)YVLGYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGKYVLGYK 9 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 380424600.0 157493000.0 177762000.0 45169600.0 True False 206474848.16438174 151240602.5108491 40495883.089398354 1.0 0.7324892298283286 0.19612986012300243 27.621390808837806 -7.158877483101935 0.4984463806597588 1.0107223812303079 1.0792122054402783e-24 0.9992980427965789 0.008855525473650101 0.08254830902380247 0.03396826884511982 0.010131876106070055 0.04533655866815573 6.936214529031712e-08 7.158877483101935 -1.0107223812303079 down SGK(ub)YVLGYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGKYVLGYK 9 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 419378000.0 131630000.0 186684000.0 101064000.0 True False 127451477.70061904 261227894.74419937 74592306.54498926 1.0 2.0496262535128738 0.5852604292294287 26.925372859481346 -6.714310240466964 1.7797887373722228 1.642429107172581 0.5882400619073248 0.4855461309847534 0.4420219164308065 0.36648995570206877 2.2655359321653035 0.19744389879328028 0.4990058357633889 1.9305886984733612e-07 6.714310240466964 -1.054189045265256 SGK(ub)YVLGYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGKYVLGYK 9 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 370338600.0 223565000.0 100899000.0 45874600.0 True False 339164449.7907973 82892785.12251478 36807465.20244856 1.0 0.24440292953357742 0.10852394826507337 28.337409717919943 -13.999999999999998 0.2413205989323771 6.033524431182513 0.04919377152631283 0.9995271706006524 0.008527420675395959 13.67042205646024 0.15547347542136933 33.18538083678333 0.06588438175594995 1.0000000000000041e-14 13.999999999999998 -5.9843306596562 SGK(ub)YVLGYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGKYVLGYK 9 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 315904700.0 157493000.0 118583000.0 39828700.0 True False 215722418.1882929 113343610.95845844 30421981.357824862 1.0 0.5254141498614515 0.14102373602761625 27.684600870360697 -7.986649716827309 0.3745858533947829 1.0726090898580092 3.3798082841033865e-23 0.998064755724554 0.01545503555231592 0.09933340176130905 0.07812760603327001 0.048051570920704396 0.08367218484635378 1.0312175206264754e-08 7.986649716827309 -1.0726090898580092 down SGK(ub)YVLGYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGKYVLGYK 9 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 550040600.0 131630000.0 392563000.0 25847600.0 True False 109456177.1977265 390448185.2013458 31252213.654200617 1.0 3.567164459763864 0.2855226123761405 26.705778134915622 -6.698013626568919 1.8379211510313427 2.59719908331815 0.2956312267322755 0.4081634676141699 1.0840310404163935 0.399672684454633 2.62332612349534 0.4707878396056722 1.2137341220262912 2.0044091353670773e-07 6.698013626568919 -2.3015678565858746 SGK(ub)YVLGYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGKYVLGYK 9 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 364115700.0 223565000.0 123201000.0 17349700.0 True False 289409299.62498754 116344756.04761697 14192232.622955201 1.0 0.4020076624986649 0.049038619841675075 28.108536040012392 -8.432008183958363 0.4344312691489988 1.0750679018556168 3.130998061425928e-19 0.9959474544419337 0.02498642459737427 0.17116977731644797 0.1345127588682054 0.082610799085076 0.07600364837622034 3.698212107073595e-09 8.432008183958363 -1.0750679018556168 SGK(ub)YVLGYK(ub)QTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGKYVLGYKQTLK 13 2 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 2 59138000.0 25672000.0 29773000.0 3693000.0 True False 33656240.60800162 25330984.45424502 3310883.7857574145 1.0 0.7526385596442013 0.09837354754857162 25.004370701274766 -7.236284108552786 0.6477986246171924 0.9985544558010371 2.1424641376030798e-23 0.9965805809307016 0.022242854134469935 0.0921667503187036 0.07019058573644651 0.02071520627817705 0.05779331307217009 5.8038461490678065e-08 7.236284108552786 -0.9985544558010371 down SGK(ub)YVLGYK(ub)QTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGKYVLGYKQTLK 13 2 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 2 90435800.0 48675000.0 35016000.0 6744800.0 True False 47129838.768347904 48998071.406027704 4978134.540337241 1.0 1.0396401236775394 0.10562596160801051 25.49013741009901 -6.89699037577699 0.9801196357739498 1.0421046847569961 0.013370542126768994 0.9850077815390935 0.052804519199474244 0.11365420101304019 0.1901868261308348 0.04062543425613593 0.1041890433576611 1.2676799580854636e-07 6.89699037577699 -1.0287341426302272 down SGK(ub)YVLGYK(ub)QTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGKYVLGYKQTLK 13 2 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 2 50497850.0 25672000.0 22527950.0 2297900.0 True False 35163632.15971406 21532590.679031577 1755183.3467360414 1.0 0.6123539963457141 0.04991473402872481 25.067580762797657 -7.602390628209803 0.5879508353810977 1.0042255406509433 5.533440342258752e-24 0.9927249606222889 0.03326908511408439 0.11790540839055037 0.11036352360320703 0.03249888496429453 0.0746200588899481 2.4980974254372046e-08 7.602390628209803 -1.0042255406509433 down SGKPAELLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGKPAELLK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 15982800.0 1119200.0 8580400.0 6283200.0 False True 1467282.0383482187 7300237.766137242 5633074.736710269 1.0 4.975347326104686 3.8391219884703687 20.48471477927035 -9.723772886515782 7.266222247849644 0.9999999981843 4.407234657287642 0.9230168392899494 0.4638620516713503 1.3765430073463415e-08 3.6842230549799297e-09 0.4491325002650005 0.14971083342166694 1.8889789288328588e-10 9.723772886515782 3.407234659103342 SGKPAELLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGKPAELLK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 17254600.0 6073900.0 3874200.0 7306500.0 False True 5881087.369184772 5421188.263686106 5392708.459698439 1.0 0.9218003276216561 0.9169577190698952 22.48765149259962 -13.999999999999954 0.39566604153298046 2.2820403501123705 0.9166441178943324 0.9998315263773815 0.0004939294199509511 26.140427902544022 0.20680682082823507 28.72438402347775 0.0012541393847196993 1.0000000000001063e-14 13.999999999999954 -1.3653962322180382 SGKPAELLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGKPAELLK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 42208700.0 3820700.0 34984000.0 3404000.0 False True 5796281.230584846 28740831.868760448 2731197.9079738 1.0 4.958495063542749 0.4711983079016719 22.466696164240947 -6.673786546333445 1.9239365877376922 3.5183382535336123 0.48893480922715377 0.2960552843440367 1.6800115159039384 0.45239956175581764 3.231918177503111 0.7020939760191705 1.8666154696584865 2.1194025555488716e-07 6.673786546333445 -3.0294034443064586 SGKPAELLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGKPAELLK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 14228500.0 1119200.0 6572800.0 6536500.0 False True 1532998.485242756 6282391.962656994 4992713.323443198 1.0 4.098107090863925 3.256828608446135 20.547924840793243 -9.295467415766762 10.604030884455995 1.0000104449911582 3.6774678496550353 0.9310601941605507 0.3434505023040579 0.0 0.0 0.332544523848864 0.11084817296453872 5.064453456645062e-10 9.295467415766762 2.677457404663877 SGKPAELLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGKPAELLK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 9802400.0 6073900.0 2640800.0 1087700.0 False True 5050716.969393545 2626573.486242239 1315133.0410434254 1.0 0.520039729440159 0.2603854163701708 22.268056768033897 -9.135420588561777 0.2014397882986817 1.420429924336908 1.8493207893758397e-10 0.9995464591866288 0.00652479375386401 0.577014320270015 0.06993607990990043 0.29569410067800406 0.13939982743296314 7.321151793889707e-10 9.135420588561777 -1.420429924151976 down SGKPAELLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGKPAELLK 9 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 9659700.0 3820700.0 2561700.0 3277300.0 False True 4945971.467256464 2419139.143084724 2680865.027937717 1.0 0.48911304060284505 0.5420300229561971 22.237822486333396 -10.801634856904725 10.928047308738892 1.0032921982925946 0.5155715321571366 0.9911300177707357 0.02160326758226237 0.0017326929439412397 3.145164019251091e-05 0.020915896813100784 0.006972424630813726 1.5789382404975892e-11 10.801634856904725 -0.48772066613545806 SGKYDLDFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGKYDLDFK 9 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 56970900.0 8570900.0 26210000.0 22190000.0 False True 11236532.900713658 22299570.165779788 19893991.661510177 1.0 1.9845596824945435 1.770474205637458 23.421693616268534 -10.19730805806076 5.906209222282993 0.9999840661905663 1.8775169440660069 0.9572675311213059 0.08740002994008376 1.834078718087871e-05 2.4925503347550593e-06 0.0846262469909889 0.028208238367992335 6.348804324215979e-11 10.19730805806076 0.8775328778754405 SGKYDLDFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGKYDLDFK 9 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 63046800.0 26940000.0 6945800.0 29161000.0 False True 26084804.44621045 9719294.161868503 21522859.288751997 1.0 0.37260368127009297 0.8251110079484915 24.636706281953657 -10.369349491309634 6.0792883395167365 1.0000588020627525 0.5988573446093761 0.5116749746557128 0.18473534253882962 0.00014725183397665026 1.527551867152103e-05 0.1788953254208079 0.05962307542573406 4.272189503892972e-11 10.369349491309634 -0.40120145745337643 SGKYDLDFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGKYDLDFK 9 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 241345000.0 21669000.0 193280000.0 26396000.0 False True 32873457.216097318 158787673.89646724 21178819.030222226 1.0 4.830269991156052 0.644252866104131 24.970419853098196 -6.665997764709261 1.9514373338276212 3.4531933851947216 0.6613893878100768 0.26148675487597894 1.6285284002628997 0.4703759762597072 3.4493370370681493 0.6727516554242353 1.8069378982833029 2.157755514977649e-07 6.665997764709261 -2.791803997384645 SGKYDLDFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGKYDLDFK 9 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 68219900.0 8570900.0 26566000.0 33083000.0 False True 11739793.349863397 25392226.277985945 25269476.765772406 1.0 2.1629193565218428 2.1524635070400486 23.484903677791426 -10.40387345957567 5.948185917904871 0.9996706017213642 2.1576914317809464 0.9999388257720896 0.004268582676292275 1.8651162911616043e-05 1.8692141557796274e-06 0.004134128402640864 0.0013776791347654533 3.945722518824026e-11 10.40387345957567 1.158020830059582 SGKYDLDFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGKYDLDFK 9 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 38589300.0 26940000.0 7742700.0 3906600.0 False True 22401803.644357335 7700988.538294381 4723451.997922443 1.0 0.34376645115511223 0.21085141504274396 24.417111557387933 -13.999999999999897 0.22447117716150247 5.039408209336997 0.14273085924858184 0.9995027625953644 0.007692514153327208 13.125120401860004 0.1500559175308923 23.557633955057263 0.07144848393769151 1.0000000000002373e-14 13.999999999999897 -4.8966773500884155 SGKYDLDFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGKYDLDFK 9 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 72727000.0 21669000.0 24736000.0 26322000.0 False True 28050947.65984776 23359419.855308466 21531666.086527538 1.0 0.8327497572834316 0.7675913964699329 24.741546175190646 -13.999999999999998 0.13037980265445476 1.7948557969427308 0.6767802131831728 0.9996438972979316 0.0018471345236071583 11.936182329895976 0.11232536538575498 2.4304987143842727 0.08077283144547129 1.0000000000000041e-14 13.999999999999998 -1.118075583759558 SGKYDLDFKSPDDPSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGKYDLDFKSPDDPSR 16 2 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 15935500.0 3428900.0 5423000.0 7083600.0 False True 4495321.105514833 4613909.538688439 6350657.022689214 1.0 1.0263804142996866 1.4127260041331122 22.099992741968897 -6.920718130707112 0.8193662096176819 0.9916946105988491 1.4760722083467144 0.9943785556143525 0.01414432476528528 0.09775073008244431 0.10343232899748286 0.01223343021167081 0.036901280522636165 1.2002780645131007e-07 6.920718130707112 0.48437759774786526 SGKYDLDFKSPDDPSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGKYDLDFKSPDDPSR 16 2 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 9542160.0 3410400.0 867860.0 5263900.0 False True 3302138.7187585793 1214401.0238301114 3885126.67638495 1.0 0.3677619649748266 1.1765485969182852 21.654969296680566 -6.698170264012743 1.8375981286714071 0.606701121380966 1.1740464147254503 0.40882977555897815 0.2669659821723132 0.3993278640758946 2.6203093421077734 0.11596348457330569 0.29888038003431067 2.0036863333880225e-07 6.698170264012743 0.5673452933444844 SGKYDLDFKSPDDPSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGKYDLDFKSPDDPSR 16 2 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 24813300.0 3428900.0 13751300.0 7633100.0 False True 4696656.992538312 13143722.09653194 5830318.988629124 1.0 2.79852714758895 1.2413763657622616 22.16320280349179 -6.6111141252991015 2.1486868745064536 2.2006192782581655 1.2468700363700886 0.054178489148355435 0.7751634730422018 0.6095293456222912 5.333859615633584 0.2976779298498754 0.8608783532588609 2.4484197536912185e-07 6.6111141252991015 -0.9537492418880769 SGLAAK(ub)HFIDVGAGVIDEDYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGLAAKHFIDVGAGVIDEDYR 21 1 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 67786300.0 22096300.0 40368000.0 5322000.0 True False 28968463.280873585 34345251.753231585 4771330.492228805 1.0 1.1856083431221573 0.16470775290931894 24.787979818758892 -6.859818757574629 1.1865785126246702 1.1006606556479757 0.11542389233546291 0.9534272294290302 0.09582321616497556 0.14698937605666018 0.39334811486969434 0.06298851538525184 0.14701120258181005 1.380960455215358e-07 6.859818757574629 -0.9852367633125128 down SGLAAK(ub)HFIDVGAGVIDEDYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGLAAKHFIDVGAGVIDEDYR 21 1 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 269147100.0 135879000.0 107921000.0 25347100.0 True False 131565595.52140412 151014418.10058007 18707934.113299463 1.0 1.147826052108067 0.14219472833424684 26.9712070319114 -6.869540322513841 1.1365788814618933 1.0833706470863917 0.08382591344207382 0.9642194708648002 0.08386160895635086 0.13729350748040653 0.3317759658679265 0.05728003451886634 0.13550036004836444 1.3503914435644048e-07 6.869540322513841 -0.999544733644318 down SGLAAK(ub)HFIDVGAGVIDEDYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGLAAKHFIDVGAGVIDEDYR 21 1 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 282082000.0 140283000.0 93514000.0 48285000.0 True False 212819567.06104493 76825696.07178321 38741448.58593272 1.0 0.36098981467125446 0.1820389408781203 27.665055560333514 -13.999999999998264 0.17855607062920023 4.301048490540027 0.037749659043269275 0.9994999505763766 0.007851138592631542 12.186395358392478 0.1339401966912828 13.951965577909132 0.13526899618034854 1.0000000000039962e-14 13.999999999998264 -4.2632988314967575 SGLAAK(ub)HFIDVGAGVIDEDYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGLAAKHFIDVGAGVIDEDYR 21 1 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 82067300.0 22096300.0 45216000.0 14755000.0 True False 30265899.240054935 43218207.61068323 11270172.888763763 1.0 1.4279505547777271 0.37237198205723315 24.851189880281783 -6.796647278682421 1.4695510869634067 1.2371337997477323 0.3589773428177428 0.8221758376432902 0.18280373402271172 0.22558270543844683 0.9620903717786325 0.097876750669892 0.22810697499723043 1.5971758002373994e-07 6.796647278682421 -0.8781564569299896 down SGLAAK(ub)HFIDVGAGVIDEDYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGLAAKHFIDVGAGVIDEDYR 21 1 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 260445000.0 135879000.0 109389000.0 15177000.0 True False 112989408.96034254 108799699.74498348 18350440.52948061 1.0 0.9629194518857109 0.16240850092349202 26.751612307345678 -6.916575655419971 0.8497437935579498 1.0199355780024058 0.042969161279305265 0.9931753792868768 0.031921081975297076 0.10022897837607439 0.11636724884094528 0.02701563158637541 0.07845436126981391 1.2117815743503008e-07 6.916575655419971 -0.9769664167231005 down SGLAAK(ub)HFIDVGAGVIDEDYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGLAAKHFIDVGAGVIDEDYR 21 1 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 1 330443400.0 140283000.0 164462000.0 25698400.0 True False 181599108.891339 155309545.12628308 21021554.887851167 1.0 0.8552329693380464 0.115758028859214 27.436181882425963 -7.045490002798717 0.7384141656995783 1.0025722735698726 4.976008372389307e-25 0.997387722167814 0.019792530776138132 0.07683330015046533 0.06786566896435077 0.018727353475969207 0.05380666097665519 9.005544927421268e-08 7.045490002798717 -1.0025722735698726 down SGLDSVSSWLPLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGLDSVSSWLPLAK 14 0 Q6PD74 Q6PD74 AAGAB Alpha- and gamma-adaptin-binding protein p34 0 4491900.0 1131000.0 1098100.0 2262800.0 False True 1095097.0240780993 1536577.0565158513 1670104.7974550945 1.0 1.4031423907935547 1.525074729210466 20.06262726559381 -12.072037993663203 0.1977941510440228 1.6036745962763193e-08 1.61454055362384 0.9994130859045063 0.005435760170640892 5.442973484070305 0.1251532071660781 2.2981765153341414 0.07842481301352744 8.471532988423501e-13 12.072037993663203 1.614540537587094 SGLEEK(ub)SDSHDIPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGLEEKSDSHDIPR 14 1 Q7KZN9-2;Q7KZN9 Q7KZN9-2 COX15 Cytochrome c oxidase assembly protein COX15 homolog 1 9171600.0 1007200.0 5095400.0 3069000.0 True False 1527996.0361831747 4186086.059458095 2462410.8048095126 1.0 2.7395922242800053 1.6115295763203938 20.54320937016754 -10.47284003500541 4.96279737763035 0.9971551652733623 2.175560900300274 0.5914999307664061 0.460529647565907 0.014515394686174563 0.0015418585728472914 0.44650794072138633 0.14863530462142388 3.3663554052532476e-11 10.47284003500541 1.1784057350269115 SGLEEK(ub)SDSHDIPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGLEEKSDSHDIPR 14 1 Q7KZN9-2;Q7KZN9 Q7KZN9-2 COX15 Cytochrome c oxidase assembly protein COX15 homolog 1 6942500.0 1007200.0 3259200.0 2676100.0 True False 1303840.2548801815 3077822.6549329464 2189077.259104789 1.0 2.360582627674575 1.6789459068403725 20.314335692259988 -10.066612641776809 6.134073847705055 0.9999980811863846 2.0197642672574982 0.7490105031047982 0.27827702599804416 7.302406478075103e-06 1.1107532088017558e-06 0.2694410775162649 0.08981352394353326 8.578025999435215e-11 10.066612641776809 1.0197661860711138 SGLGELILPENEPGSSIMPGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGLGELILPENEPGSSIMPGK 21 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 6919600.0 0.0 3987200.0 2932400.0 False True 0.0 3392325.3019838687 2628983.3775670337 0.0 SGLGELILPENEPGSSIMPGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGLGELILPENEPGSSIMPGK 21 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 10103200.0 3385400.0 1694000.0 5023800.0 False True 3277932.330074267 2370423.0340933003 3707916.069230554 1.0 0.723145811261941 1.1311752946243845 21.64435464094459 -6.723973590297658 1.7449681693400443 0.8322851599580791 1.1306884049992865 0.5312292293024011 0.11644803801802053 0.3476498148197081 2.0708129898973997 0.05294410162053923 0.13229484855012286 1.8881061624492367e-07 6.723973590297658 0.2984032450412074 SGLGELILPENEPGSSIMPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGLGELILPENEPGSSIMPGK 21 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 9299000.0 0.0 4858500.0 4440500.0 False True 0.0 4643835.405089007 3391745.3549681823 0.0 SGLGSVLRDLVK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGLGSVLRDLVK 12 1 A0A087WT45;Q4V328-4;Q4V328 A0A087WT45 GRIPAP1 GRIP1-associated protein 1 1 13282800.0 4098600.0 5536300.0 3647900.0 True False 5373304.290898861 4710305.620328378 3270450.3011276745 1.0 0.8766124837386465 0.6086478866769305 22.357378109684532 -6.958402158081183 0.45739587232972473 1.0080171401591072 0.4664880933301501 0.9997062707713387 0.0027997885443412007 0.08027691025986178 0.023278108607269424 0.003623434526481317 0.022143161206433237 1.1005197527420991e-07 6.958402158081183 -0.5415290468289571 SGLGSVLRDLVK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGLGSVLRDLVK 12 1 A0A087WT45;Q4V328-4;Q4V328 A0A087WT45 GRIPAP1 GRIP1-associated protein 1 1 24599900.0 8387200.0 8842700.0 7370000.0 True False 8120952.926921168 12373636.224071315 5439575.904739284 1.0 1.523668014753834 0.6698199033646592 22.953217595045047 -6.740752196424405 1.6839002271879466 1.3113114958470338 0.6692348837198826 0.6083085085145898 0.2200201729337065 0.31646946033859663 1.762242606065845 0.1033526155773867 0.25341304119341035 1.8165518713077036e-07 6.740752196424405 -0.6420766121271512 SGLGSVLRDLVK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGLGSVLRDLVK 12 1 A0A087WT45;Q4V328-4;Q4V328 A0A087WT45 GRIPAP1 GRIP1-associated protein 1 1 18801600.0 4098600.0 10413000.0 4290000.0 True False 5613963.180500318 9952919.228813795 3276790.3553233887 1.0 1.772886445601303 0.5836857581654749 22.420588171207424 -6.731296306770427 1.718425890851498 1.4644561499861521 0.5842208128180832 0.5652452224089184 0.3248730278546234 0.3338411188439385 1.931898990341605 0.14977760179502847 0.3711297792763456 1.8565373602623396e-07 6.731296306770427 -0.8802353371680689 SGLGSVLRDLVK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGLGSVLRDLVK 12 1 A0A087WT45;Q4V328-4;Q4V328 A0A087WT45 GRIPAP1 GRIP1-associated protein 1 1 24336000.0 8387200.0 11698000.0 4250800.0 True False 6974328.415959682 11634980.552128792 5139622.626521455 1.0 1.6682581975210575 0.7369344143244267 22.733622870479323 -6.714119006276592 1.7805382621724481 1.409088921577313 0.7388464110972922 0.48464602860769257 0.28142591156390234 0.36684929561877117 2.2695699630979007 0.12566288253253025 0.31765650825175806 1.9314389875704793e-07 6.714119006276592 -0.6702425104800208 SGLIFYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGLIFYR 7 0 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 97376000.0 29657000.0 22970000.0 44749000.0 False True 38880614.1987965 19542965.536358725 40118802.74271827 1.0 0.502640350186743 1.031845910087503 25.212547673653145 -10.145262897993502 14.813118110706188 1.0000000000000184 0.7672431301379052 0.20504061537281515 0.21604726513345673 0.0 0.0 0.2091868665224477 0.06972895498796135 7.157100275659053e-11 10.145262897993502 -0.2327568698621132 SGLIFYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGLIFYR 7 0 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 59720600.0 21205000.0 7727600.0 30788000.0 False True 20531858.882030178 10813270.978901632 22723699.179798245 1.0 0.5266581579890746 1.1067531347435084 24.29136091408779 -6.689735215712342 1.8670872646836865 0.7031780545469313 1.1047574812198107 0.36932481874165135 0.20019998089795196 0.4172285894338544 2.8196787244871677 0.08578066490294656 0.22347558074918678 2.0429831480699727e-07 6.689735215712342 0.4015794266728794 SGLIFYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGLIFYR 7 0 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 53443000.0 15090000.0 24550000.0 13803000.0 False True 22892633.22677132 20168860.68997453 11074830.999930192 1.0 0.8810196926751297 0.48377270059867805 24.448380082749928 -6.949024154323111 0.5694579197824813 1.004960611360104 0.34053595669288433 0.9991224481788706 0.006538468633612789 0.08388001229868747 0.037602699554102274 0.0069313973729386745 0.03309407628299822 1.1245424281192072e-07 6.949024154323111 -0.6644246546672197 down SGLIFYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGLIFYR 7 0 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 83810000.0 29657000.0 28403000.0 25750000.0 False True 40621994.35028979 27148061.54383927 19668380.337896764 1.0 0.6683094214857425 0.4841805689866739 25.275757735176036 -11.27322920314467 0.09673863173950169 2.0623274424272435 1.1619451521364063e-14 0.9998956722715076 0.00218004100399433 3.897320852553797 0.062080229787772216 1.2252386582061772 0.3253942856924092 5.330534970615263e-12 11.27322920314467 -2.062327442427232 SGLIFYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGLIFYR 7 0 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 47166300.0 21205000.0 16392000.0 9569300.0 False True 17632897.040779423 16303693.042442743 11570196.386555877 1.0 0.9246179459187766 0.6561710398352353 24.071766189522066 -6.9475472510973155 0.5851596445932704 1.0031506711279377 0.564242470088944 0.9989944125641432 0.004679259069583002 0.08448602522668043 0.04015681028486123 0.004875696571146853 0.022457252323466556 1.1283731642185286e-07 6.9475472510973155 -0.43890820103899364 SGLIFYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGLIFYR 7 0 P34897;P34897-3;P34897-2;H0YIZ0;G3V2Y4 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 46926000.0 15090000.0 17477000.0 14359000.0 False True 19534302.46836965 16504389.586482288 11745809.335781815 1.0 0.8448927016056262 0.6012914643254282 24.219506404842377 -6.964482346969978 0.3668285833793497 1.0194197584188485 0.418327095330529 0.9999020718884641 0.0016239312108992502 0.0781370742482428 0.015482042227161876 0.003227177733649989 0.020724790294745565 1.085219660315038e-07 6.964482346969978 -0.6010926630883195 SGLIYLTNHIAPHAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGLIYLTNHIAPHAR 15 0 Q13422-4;Q13422-3;Q13422-7;Q13422;Q13422-2;A0A0A0MRA0;A0A0A0MST1;A0A087WU46;Q13422-6;Q13422-5;R9R4D9 Q13422-4 IKZF1 DNA-binding protein Ikaros 0 10946500.0 2423900.0 3336000.0 5186600.0 False True 3177756.37308099 2838281.8036261536 4649940.3853802895 1.0 0.8931716187148422 1.463277809705703 21.599577092116064 -6.8582556722943036 1.1944621564320015 0.9422832802370147 1.4899862873018563 0.9514868114362969 0.054501440245991815 0.14861469558205673 0.4038935279380212 0.035611200655568075 0.08297377113969927 1.3859396759731132e-07 6.8582556722943036 0.5477030070648417 SGLIYLTNHIAPHAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGLIYLTNHIAPHAR 15 0 Q13422-4;Q13422-3;Q13422-7;Q13422;Q13422-2;A0A0A0MRA0;A0A0A0MST1;A0A087WU46;Q13422-6;Q13422-5;R9R4D9 Q13422-4 IKZF1 DNA-binding protein Ikaros 0 8562700.0 2977800.0 1156700.0 4428200.0 False True 2883271.3689653073 1618576.342110813 3268321.576847555 1.0 0.5613680208990027 1.13354629468 21.459275196734904 -6.701893337283983 1.8242795383631225 0.7281322332105696 1.1318971381401346 0.4265093208198677 0.18508868882250157 0.3915890675400803 2.5349532031788438 0.08090451158483145 0.2075676503286192 1.9865827621339934e-07 6.701893337283983 0.40376490492956496 SGLIYLTNHIAPHAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGLIYLTNHIAPHAR 15 0 Q13422-4;Q13422-3;Q13422-7;Q13422;Q13422-2;A0A0A0MRA0;A0A0A0MST1;A0A087WU46;Q13422-6;Q13422-5;R9R4D9 Q13422-4 IKZF1 DNA-binding protein Ikaros 0 5263800.0 2423900.0 2839900.0 0.0 False True 3320081.333434518 2714423.8277065526 0.0 1.0 0.8175775094336524 0.0 21.662787153638956 -7.2239756496276515 0.8729621735504404 0.9898777489595814 5.371633577344889e-16 0.989104328319675 0.045388793891524046 0.09547082819448204 0.1391700192162182 0.038349010968600133 0.06740310749647292 5.970687625769982e-08 7.2239756496276515 -0.9898777489595808 down SGLIYLTNHIAPHAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGLIYLTNHIAPHAR 15 0 Q13422-4;Q13422-3;Q13422-7;Q13422;Q13422-2;A0A0A0MRA0;A0A0A0MST1;A0A087WU46;Q13422-6;Q13422-5;R9R4D9 Q13422-4 IKZF1 DNA-binding protein Ikaros 0 6020000.0 2977800.0 1257400.0 1784800.0 False True 2476172.638907468 1250626.136625641 2157993.4280171967 1.0 0.5050641934148178 0.8715036238221833 21.23968047216918 -9.89511791258811 5.904785442967102 1.0000000932540194 0.6882839086182709 0.4910512570408285 0.1495982710231798 1.837729222564275e-07 3.4360249990782036e-08 0.14484794624099706 0.04828263435772986 1.2731573670654826e-10 9.89511791258811 -0.31171618463574846 SGLIYLTNHIAPHAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGLIYLTNHIAPHAR 15 0 Q13422-4;Q13422-3;Q13422-7;Q13422;Q13422-2;A0A0A0MRA0;A0A0A0MST1;A0A087WU46;Q13422-6;Q13422-5;R9R4D9 Q13422-4 IKZF1 DNA-binding protein Ikaros 0 14085600.0 3435500.0 5121400.0 5528700.0 False True 4447322.473829289 4836389.58792758 4522533.329252511 1.0 1.087483450185543 1.0169114913222075 22.084505587129637 -10.164004790203354 3.921710722736723 0.9999752378799961 1.0521974707246162 0.42176900061684175 0.02881088167306262 2609405.714897715 6781378.31204187 288.84510278072685 0.009862730455628023 6.854806656614722e-11 10.164004790203354 0.05222223284462013 SGLPNFLAVALALGELGYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGLPNFLAVALALGELGYR 19 0 Q6XQN6;G5E977;Q6XQN6-3;Q6XQN6-2;C9J8U2 Q6XQN6 NAPRT Nicotinate phosphoribosyltransferase 0 2343930000.0 970180000.0 824990000.0 548760000.0 False True 1471833989.65865 677764088.8237092 440297345.4699482 1.0 0.46048949377836923 0.2991487821069159 30.454967810841374 -13.999999999999998 0.16916827742221865 3.7148935665328784 0.15556032584833646 0.9995152898166808 0.006597882158472163 12.083546686610077 0.13022915119079043 10.764507038911798 0.13254199081237406 1.0000000000000041e-14 13.999999999999998 -3.559333240684542 SGLPNFLAVALALGELGYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGLPNFLAVALALGELGYR 19 0 Q6XQN6;G5E977;Q6XQN6-3;Q6XQN6-2;C9J8U2 Q6XQN6 NAPRT Nicotinate phosphoribosyltransferase 0 1584110000.0 970180000.0 143170000.0 470760000.0 False True 1255917135.1068847 135202463.6434554 385086510.4055042 1.0 0.10765237599210635 0.30661776931065715 30.226094132933824 -10.601088367322225 9.512932222638252 1.000127168597793 0.207135072651382 0.9549000701726018 0.08122728168376847 0.00021911123768411788 9.188052248368669e-06 0.0786599812467445 0.026215992434911167 2.505599378639877e-11 10.601088367322225 -0.7929920959464111 SGLSSPIYIDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGLSSPIYIDLR 12 0 P11172;E9PFD2;F2Z3P2;F2Z303;F8WDG4 P11172 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 0 30536500.0 7357500.0 11306000.0 11873000.0 False True 9645753.750131361 9619188.870442826 10644495.853858061 1.0 0.9972459508736502 1.103542152287798 23.201462548820718 -6.900951675193205 0.9552208267312109 0.9956952533265335 1.1149183462122458 0.987034158874379 0.005633274654193147 0.11070851320859898 0.17349063325040268 0.0044149593020721 0.011542938650501338 1.2561697324115834e-07 6.900951675193205 0.11922309288571231 SGLSSPIYIDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGLSSPIYIDLR 12 0 P11172;E9PFD2;F2Z3P2;F2Z303;F8WDG4 P11172 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 0 28962200.0 10220000.0 7222200.0 11520000.0 False True 9895571.694145173 10106062.12327546 8502566.40740794 1.0 1.021271174181359 0.8592294280924243 23.238351627428976 -6.87385760466424 1.1134466431010666 1.0123629956545237 0.8490151995839018 0.9683857845057037 0.012784076825428148 0.13321197819009362 0.3063293490033544 0.008887817453510244 0.021195759255051766 1.3370338278313477e-07 6.87385760466424 -0.1633477960706219 SGLSSPIYIDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGLSSPIYIDLR 12 0 P11172;E9PFD2;F2Z3P2;F2Z303;F8WDG4 P11172 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 0 35161700.0 7639700.0 17079000.0 10443000.0 False True 11589983.43688304 14031119.011163924 8378936.472670493 1.0 1.210624595589361 0.7229463716061951 23.46637516881789 -6.789332468609561 1.4989439284864567 1.1178229365012322 0.7178518529230099 0.7991469602266323 0.08950263580008816 0.2363625520408313 1.0491462697592784 0.0470000835065757 0.11009504981696774 1.6243048138057876e-07 6.789332468609561 -0.3999710835782223 SGLSSPIYIDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGLSSPIYIDLR 12 0 P11172;E9PFD2;F2Z3P2;F2Z303;F8WDG4 P11172 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 0 43173500.0 7357500.0 13458000.0 22358000.0 False True 10077766.578961382 12863381.060345357 17077500.877463955 1.0 1.2764118874512633 1.6945719811684672 23.26467261034361 -6.965115715154744 0.3560653707184773 0.9623081563815139 2.022918321101861 0.9999155052707311 0.0026245163762429586 0.07792176360211077 0.014721919326847821 0.005657420199607226 0.03580205581340464 1.0836381466808561e-07 6.965115715154744 1.060610164720347 SGLSSPIYIDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGLSSPIYIDLR 12 0 P11172;E9PFD2;F2Z3P2;F2Z303;F8WDG4 P11172 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 0 22733500.0 10220000.0 5110900.0 7402600.0 False True 8498382.822766596 5083366.567265784 8950449.434244778 1.0 0.598156928592083 1.0531944277995016 23.018756902863252 -6.673599865059492 1.924693559853801 0.7443003981324707 1.051383099033172 0.2950380860906088 0.17055443183060187 0.45291429610229644 3.2379967411295056 0.07125398131293824 0.18947799798997805 2.1203137755466864e-07 6.673599865059492 0.30708270090070133 SGLSSPIYIDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGLSSPIYIDLR 12 0 P11172;E9PFD2;F2Z3P2;F2Z303;F8WDG4 P11172 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 0 28771300.0 7639700.0 12902000.0 8229600.0 False True 9889742.251000915 12183992.358230503 6731897.242826792 1.0 1.2319828008659572 0.6806949131708134 23.23750149091034 -6.7923984302482125 1.4868118580773457 1.1292519083904922 0.6744443796044267 0.8089792842788697 0.09877602634583511 0.2317948504076279 1.0122193586121637 0.052285797046434025 0.12219947759389713 1.612878191887229e-07 6.7923984302482125 -0.45480752878606545 SGLTGYIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGLTGYIK 8 0 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 0 8821900.0 2420500.0 1721900.0 4679500.0 False True 3173298.9401553404 1464999.2319136313 4195310.22893361 1.0 0.46166442542659286 1.322065871527452 21.597552005853814 -6.737527313230042 1.6956371597396898 0.6787814467540105 1.3223146071907068 0.5938435264139985 0.226202773489616 0.3223062950162862 1.8185629437296311 0.10557444510468685 0.25978795828211126 1.8300910063717367e-07 6.737527313230042 0.6435331604366963 SGMFWLR ddPTM_RPMI8226_Bortezomib_1h_R1 2 SGMFWLR 7 0 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 27825230.0 7585800.0 7485030.0 12754400.0 False True 9945057.26099171 6368292.7004184285 11434697.036843862 1.0 0.6403475146792056 1.1497869481048728 23.245548247061016 -6.716986511085535 1.7698593377680556 0.780498661312438 1.1488791468985347 0.498436918298625 0.15140094169412094 0.36118436191952746 2.2093377281802145 0.06796283910577958 0.17123914747866453 1.9187283342445392e-07 6.716986511085535 0.3683804855860967 SGMFWLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGMFWLR 7 0 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 18308400.0 6564200.0 2428900.0 9315300.0 False True 6355823.064061423 3398772.436546172 6875343.476990201 1.0 0.5347493790008573 1.0817392818667926 22.599647532249406 -6.681411747104583 1.8973152844289067 0.7060010208646638 1.0796600578928703 0.33047013387260316 0.1971239013432471 0.43535338533904505 3.031331547406919 0.08333915324569131 0.21936899933364418 2.0825155497963842e-07 6.681411747104583 0.3736590370282066 SGMFWLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGMFWLR 7 0 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 19235400.0 5629800.0 6003500.0 7602100.0 False True 8540818.193510758 4932128.519440403 6099541.602881211 1.0 0.5774772870341384 0.7141636157898305 23.025942853125265 -10.911127022980647 11.18207779463833 1.0359284876936983 0.6458204514119844 0.8995209025146652 0.05580196004429286 0.029678554672358453 0.00023587894991033737 0.0320822536126448 0.018010005161439826 1.2270802807281974e-11 10.911127022980647 -0.39010803628171387 SGMFWLR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SGMFWLR 7 0 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 34199180.0 7585800.0 9983780.0 16629600.0 False True 10390475.258536903 9542663.587654535 12702030.977362655 1.0 0.9184049189486497 1.2224687188323324 23.308758308583908 -6.835288427948688 1.304154013262773 0.9565342471969988 1.2315685804210617 0.9160341630418626 0.0372345912369421 0.1743761644088933 0.5781447969594389 0.02240373847326382 0.051565215008145114 1.461206421272084e-07 6.835288427948688 0.2750343332240629 SGMFWLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGMFWLR 7 0 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 19129900.0 6564200.0 7141300.0 5424400.0 False True 5458423.143366389 7102828.399462935 6558616.96040815 1.0 1.3012601282286054 1.2015589096237116 22.380052807683683 -10.113876747241875 4.314664370166442 0.9999694114411507 1.2514095188241086 0.8944942060714216 0.04070285234101548 5976329.976638343 7004469.788171302 1702.3537275690967 0.01393366835570619 7.693487504542557e-11 10.113876747241875 0.25144010738295786 SGMFWLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGMFWLR 7 0 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 23066000.0 5629800.0 9867500.0 7568700.0 False True 7287887.079948814 9318364.950770391 6191274.261420136 1.0 1.278609952177777 0.8495293894514651 22.797069175217715 -6.731434968900382 1.7178654753478817 1.1673963262290024 0.8497107509573227 0.5659626926023547 0.11710839054429148 0.33355554812139654 1.9290391767036796 0.05400688412867749 0.1338040383589155 1.8559446971195022e-07 6.731434968900382 -0.3176855752716796 SGMYTVAMAYCGSGNNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGMYTVAMAYCGSGNNK 17 0 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 21491000.0 5893100.0 6906900.0 8691000.0 False True 7725911.168861572 5876417.442885328 7791738.689958766 1.0 0.7606115724666337 1.0085203569725867 22.881273659141023 -11.067395816927014 10.621263371846625 1.600015679585683 0.8845659647196106 0.22425480326209146 0.10120833746552953 0.04277629071269232 0.00027143165311075166 0.0029150716825834255 0.032664850458444666 8.562570949335081e-12 11.067395816927014 -0.7154497148660725 SGMYTVAMAYCGSGNNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGMYTVAMAYCGSGNNK 17 0 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 15176600.0 2770800.0 6621700.0 5784100.0 False True 4203506.172613524 5440005.899421763 4640870.099738904 1.0 1.2941591319323427 1.1040474092734471 22.003161760943794 -10.243477320894794 3.765747594628042 0.9997196884622038 1.1991032706745568 0.5938985487568844 0.07761278606843075 55225821.265155494 81209338.2828294 173947.33227129647 0.028403363460539625 5.7085088555191234e-11 10.243477320894794 0.19938358221235297 SGMYTVAMAYCGSGNNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGMYTVAMAYCGSGNNK 17 0 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 17978400.0 5893100.0 4955300.0 7130000.0 False True 8071938.325039375 4736358.46101422 5446040.846959376 1.0 0.5867684155021237 0.6746881142619249 22.944483720663914 -9.970493585287635 5.734070625892017 1.000000461406359 0.630728264881818 0.9592188716558282 0.03589306671754404 2.1173282590506781e-07 3.8022131930476836e-08 0.034753355909350296 0.011584437470002939 1.0703021916086744e-10 9.970493585287635 -0.3692721965245409 SGMYTVAMAYCGSGNNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGMYTVAMAYCGSGNNK 17 0 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 15731300.0 2770800.0 7397500.0 5563000.0 False True 3586855.220633447 6985822.622074879 4550591.081200233 1.0 1.9476176740808528 1.2686854643652408 21.774288083036243 -10.115394078778701 4.5035494926016595 0.9999411592679429 1.6081515692360853 0.5168655459867619 0.2771729140420681 42726738.817572944 47984147.83275593 21796.135929536213 0.09488366437565847 7.666655014242162e-11 10.115394078778701 0.6082104099681424 SGNALFHASTLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGNALFHASTLHR 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 17489100.0 6238900.0 3620800.0 7629400.0 False True 8179258.317593542 3080590.753767854 6839982.874372506 1.0 0.37663448617847406 0.8362595493114258 22.963538597082618 -9.840936032295462 6.280150255425262 1.0000000206969986 0.6064470177448943 0.49432307453557933 0.1876411462788138 5.4470662830020466e-08 9.483890427163613e-09 0.18168276947920428 0.06056091955002809 1.4423277779005377e-10 9.840936032295462 -0.39355300295210427 SGNALFHASTLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGNALFHASTLHR 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 8074400.0 2097700.0 1118200.0 4858500.0 False True 2031109.6617229255 1564703.0913359674 3585913.098124256 1.0 0.7703685925104997 1.7654945794913113 20.95383670366668 -6.845969157862228 1.2543250352879523 0.877758916678333 1.8023007597230072 0.934242011434686 0.10909679259456646 0.16194537895695388 0.49233317410148447 0.06812289943042696 0.1572927414303147 1.4257088390679659e-07 6.845969157862228 0.9245418430446742 SGNALFHASTLHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGNALFHASTLHR 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 13114600.0 3910100.0 5282400.0 3922100.0 False True 5931907.5666003125 4339714.448420425 3146895.215882501 1.0 0.7315883465304226 0.5305030768856106 22.50006468663015 -7.285032240440783 0.133447637674506 1.3192784066562728 8.198013593025315e-13 0.9999966169188892 0.00035370310023384436 0.10596948830465822 0.007450103033327319 0.02488177716445987 0.04567045401429193 5.1876152653289284e-08 7.285032240440783 -1.319278406655453 SGNALFHASTLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGNALFHASTLHR 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 15092900.0 6238900.0 3771800.0 5082200.0 False True 8545589.929933006 3605149.404325352 3881889.0311945234 1.0 0.42187250194365633 0.454256413310597 23.02674865860551 -9.976403410103956 5.4169473150708205 1.0000014948120748 0.4380644576448 0.9975153425028281 0.013220676458747962 36360467.19780113 22.476070480346483 726.9344153837629 0.004525789200490061 1.0558363019133101e-10 9.976403410103956 -0.5619370371672747 SGNALFHASTLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGNALFHASTLHR 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 7138900.0 2097700.0 3382700.0 1658500.0 False True 1744330.4938666793 3364476.7236866173 2005284.6819624142 1.0 1.928806917907248 1.149601345050888 20.734241979100958 -10.139381120505568 4.228830803347425 0.9998795509698671 1.5392041315362954 0.3896748210593929 0.3181093432415892 224052282.89548948 284203289.6759927 336471.38382143236 0.11641608944482197 7.254690336633518e-11 10.139381120505568 0.5393245805664283 SGNALFHASTLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGNALFHASTLHR 13 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 13093700.0 3910100.0 5251000.0 3932600.0 False True 5061701.529593925 4958777.234000022 3216907.1518835225 1.0 0.9796660678247932 0.6355386885369353 22.2711910087226 -6.919020068859704 0.8319626133906749 1.0078644771446166 0.5812769313774323 0.9939043350969852 0.01305582299071077 0.09875186954002028 0.10862745731423361 0.011190935621686887 0.03321447197895134 1.2049802566376613e-07 6.919020068859704 -0.4265875457671843 SGNIVAGIANESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGNIVAGIANESK 13 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 18028300.0 4148100.0 6461100.0 7419100.0 False True 5438199.270257541 5497129.06517054 6651442.701032455 1.0 1.0108362698725102 1.2230965381151724 22.374697585884558 -6.91749333846637 0.8431193249263634 0.9948802136190591 1.2554256949075957 0.9934555551573335 0.00830899709265602 0.09966923548612396 0.11342626944412953 0.007065593163738378 0.02068287628983566 1.2092237307790798e-07 6.91749333846637 0.2605454812885366 SGNIVAGIANESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGNIVAGIANESK 13 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 14871700.0 3563200.0 2390500.0 8918000.0 False True 3450088.166397066 3345039.116292813 6582108.265734724 1.0 0.969551778088629 1.9078087133664277 21.718201799504417 -6.8994011463689535 0.9650677139765985 0.960346992065454 2.0050980120222244 0.986265342886465 0.051014888440100666 0.11184677661668554 0.1799260032666277 0.03969149774118582 0.10296127301049039 1.2606625558599622e-07 6.8994011463689535 1.0447510199567702 SGNIVAGIANESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGNIVAGIANESK 13 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 34442700.0 2928800.0 29057000.0 2456900.0 False True 4443203.72396076 23871551.3266228 1971292.6381024737 1.0 5.372598874521834 0.4436646979457481 22.083168860753066 -6.672594840105203 1.9279827390233473 3.7846870972835 0.46321775690169514 0.29073619178236365 1.8562660167451799 0.4551434199923201 3.2640469072438196 0.7743970250826251 2.062163796085081 2.1252261931418384e-07 6.672594840105203 -3.3214693403818045 SGNIVAGIANESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGNIVAGIANESK 13 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 20489400.0 4148100.0 5206300.0 11135000.0 False True 5681764.668187518 4976268.45106821 8505142.332523528 1.0 0.8758314963184914 1.4969191491059535 22.43790764740745 -6.854718379784889 1.2120497768814422 0.933364393541643 1.5241101131316748 0.9468992867640648 0.061837041318343056 0.15234413012038017 0.42830062673700964 0.039867262247967515 0.09258120400582939 1.3972741360613731e-07 6.854718379784889 0.5907457195900317 SGNIVAGIANESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGNIVAGIANESK 13 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 7298300.0 3563200.0 1844200.0 1890900.0 False True 2962958.6765246456 1834264.9285549591 2286278.4474662207 1.0 0.6190653089723244 0.7716200923017509 21.498607074938693 -10.091070829634374 5.0883488530851535 1.0000072254164407 0.6953427020335948 0.8417103810619426 0.06228022949917211 5.105077057457732e-06 9.118929384010355e-07 0.06030400257780121 0.0201008576369471 8.108288079775931e-11 10.091070829634374 -0.3046645233828459 SGNIVAGIANESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGNIVAGIANESK 13 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 11222700.0 2928800.0 4148800.0 4145100.0 False True 3791389.3352790624 3917915.6329117 3390734.332317653 1.0 1.033372013909335 0.8943250171557706 21.854295182845515 -6.843337560715243 1.2667236349796926 1.0177535234928394 0.8894387861484224 0.9300502425773945 0.015675382494418084 0.16493971110865902 0.5126438962635246 0.009697372046237456 0.022365986603261126 1.434374115080393e-07 6.843337560715243 -0.128314737344417 SGNIVAGIANESK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGNIVAGIANESKK 14 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 24743200.0 8065400.0 12049000.0 4628800.0 True False 10573817.505444692 10251336.166634144 4149856.1785848774 1.0 0.9695019004588934 0.39246527344055493 23.33399299664243 -6.917838394198796 0.8406055266012665 1.0137508630168317 0.303888040449235 0.9935589941959114 0.02243020234850084 0.0994605626292038 0.11232908393520925 0.01910785052735536 0.056105786581471105 1.2082633596835355e-07 6.917838394198796 -0.7098628225675967 down SGNIVAGIANESK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGNIVAGIANESKK 14 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 39415400.0 8104100.0 17004800.0 14306500.0 True False 7846839.781460055 23794905.318860494 10559198.464199802 1.0 3.03241890768324 1.3456625543888778 22.90368031255394 -6.600321257977767 2.190127112899837 2.3666210376673997 1.3512331418739845 0.021251175205944328 0.8784185003081346 0.6398319129010744 5.800998526229624 0.33292780708969655 0.9767078479705945 2.510029016328234e-07 6.600321257977767 -1.0153878957934153 SGNIVAGIANESK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGNIVAGIANESKK 14 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 64864000.0 15785000.0 30110000.0 18969000.0 True False 23946999.038077246 24736635.24949621 15219768.835591959 1.0 1.0329743284393753 0.635560589925759 24.51334153753623 -6.886762815071821 1.0413180611293968 1.02303980996697 0.6034679686988436 0.9787450447111891 0.0262531872991204 0.12180999964633824 0.23749274569549414 0.019286383591931456 0.04755477871694889 1.297887903987442e-07 6.886762815071821 -0.4195718412681264 SGNIVAGIANESK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGNIVAGIANESKK 14 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 18271800.0 8065400.0 6581900.0 3624500.0 True False 11047396.339239545 6291089.894567319 2768467.7489206577 1.0 0.5694635823123162 0.25059911529445744 23.39720305816532 -8.017520794314626 0.266708702419634 1.1592944650150747 3.0964017305819996e-19 0.9994827410606635 0.006983832200289315 0.09852220958713621 0.050350727590183136 0.06618291354265014 0.09444249171023401 9.604598298170721e-09 8.017520794314626 -1.1592944650150747 down SGNIVAGIANESK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGNIVAGIANESKK 14 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 32144300.0 8104100.0 20860000.0 3180200.0 True False 6738918.2225031955 20747623.039614182 3845165.116416561 1.0 3.078776497143395 0.570590855899756 22.684085587988218 -6.686684291095245 1.878524715040896 2.307326780717414 0.5796705542634846 0.35478823970903994 0.87978262865742 0.4238446962862762 2.897291319622769 0.3750578037266263 0.9806602143584184 2.057385662050258e-07 6.686684291095245 -1.7276562264539295 SGNIVAGIANESK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGNIVAGIANESKK 14 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 43633000.0 15785000.0 14992000.0 12856000.0 True False 20433993.66886781 14157682.020972842 10516339.913699472 1.0 0.6928494865173009 0.5146492694534612 24.28446785962868 -10.661451120332234 0.09369657382242598 1.929223517765155 1.179276137607088e-13 0.9999251549048965 0.0017342412146240202 2.6856001423789393 0.052619427860089135 0.8641352752235818 0.3109468387649313 2.1804637936915174e-11 10.661451120332234 -1.9292235177650372 SGNLHLIHVTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGNLHLIHVTSK 12 0 P50748;E7ES84 P50748 KNTC1 Kinetochore-associated protein 1 0 4522300.0 1546600.0 1401100.0 1574600.0 False True 2118419.8152934643 1339194.7691818897 1202711.9099049435 1.0 0.6321668441325315 0.5677401151661395 21.01455709133832 -13.999999999999998 0.24506096107025313 3.4957898829480474 0.5405902325811376 0.999533654657029 0.0041118863600784605 13.807590145046962 0.15665891161978676 16.91424964772469 0.030571769265455326 1.0000000000000041e-14 13.999999999999998 -2.95519965036691 SGNLTEDDK(ub)HNNAKYAVSMAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGNLTEDDKHNNAKYAVSMAR 21 2 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 1 2302330.0 644780.0 902520.0 755030.0 True False 883172.5905243247 862643.6821654697 576707.4643309589 1.0 0.9767554965143707 0.6529952022045628 19.752335872856964 -6.921357363830311 0.8146065580015607 1.0068001714495922 0.5991221767833319 0.9945494944765598 0.011693201603025312 0.09737976470427921 0.10152732900959602 0.010147959657772222 0.030803367970815437 1.1985126883778594e-07 6.921357363830311 -0.4076779946662603 SGNLTEDDK(ub)HNNAKYAVSMAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGNLTEDDKHNNAKYAVSMAR 21 2 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 1 9167200.0 2555400.0 2628200.0 3983600.0 True False 3308015.674464669 2481938.359626525 3258625.675187713 1.0 0.7502801086419196 0.9850695993800124 21.657534639812464 -10.533662143426003 8.196202180926708 1.000019927050643 0.8676748540605307 0.29751229521993416 0.09585240821270737 3.4908060863388594e-05 1.9862298875836136e-06 0.0928226587317572 0.03093623172514088 2.9264280882827437e-11 10.533662143426003 -0.13234507299011222 SGNVAELALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGNVAELALK 10 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 0 52671000.0 10233000.0 24888000.0 17550000.0 False True 13415562.096512966 21174807.412664194 15734094.351487333 1.0 1.578376460138636 1.1728240858112842 23.67740416732752 -10.536493878665109 5.365714525911048 0.9987762750227073 1.3756002729748849 0.5335079438754414 0.16556606351270586 0.002431072725449035 0.000210002606254663 0.16079400943229952 0.053436217223485225 2.907408938777601e-11 10.536493878665109 0.3768239979521776 SGNVAELALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGNVAELALK 10 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 0 161969000.0 9785000.0 133040000.0 19144000.0 False True 14844560.379321238 109297972.55373554 15360180.00888673 1.0 7.362829869046829 1.0347345840085478 23.82343103285005 -6.644897696817356 2.026729896047424 5.145319493134799 1.0611927825478158 0.1736960011298615 2.7191416828217005 0.5211020059289972 4.096743388229639 1.0902990679300097 3.0113588544571743 2.2651778340815042e-07 6.644897696817356 -4.084126710586983 SGNVAELALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGNVAELALK 10 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 0 39501000.0 9785000.0 16531000.0 13185000.0 False True 12666875.391186025 15611035.318083134 10785465.289524565 1.0 1.2324298484017409 0.851470071066571 23.5945573549425 -6.741551245394755 1.6807937034118092 1.1380413841483343 0.8511593935913981 0.6120186894708718 0.09765434186995205 0.31499787300851345 1.747847862918884 0.04595002448196109 0.11257553655602079 1.813212709801143e-07 6.741551245394755 -0.2868819905569362 SGNVAELALK(ub)ATLVESSTSGFTPGGGGSSVSMIASR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGNVAELALKATLVESSTSGFTPGGGGSSVSMIASR 36 1 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YDS9 P49321 NASP Nuclear autoantigenic sperm protein 1 71172000.0 17196000.0 22776000.0 31200000.0 True False 26087589.19599468 18711444.850299783 25033306.324554224 1.0 0.7172546573668301 0.9595868033830308 24.636860292319184 -10.131937809207454 6.804361575796917 1.000000200344205 0.8384207307281903 0.3721638996624126 0.09893168433555338 3.007086146142928e-07 3.8179147988859215e-08 0.09579030993309623 0.031930063820320584 7.3800990527981e-11 10.131937809207454 -0.16157946961601466 SGPEPLQEGPGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGPEPLQEGPGPK 13 0 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 0 4527500.0 1426000.0 570200.0 2531300.0 False True 1380732.410552935 797883.833553718 1868276.5926277507 1.0 0.5778699967173172 1.353105481082733 20.39700231804788 -6.758853311445535 1.6169332793318523 0.7544525093001914 1.355763913904082 0.6862144762136994 0.1775200979653434 0.2848471993693946 1.4675437545887333 0.08663729914549614 0.20842732305884246 1.7423952904626527e-07 6.758853311445535 0.6013114046038907 SGPEPLQEGPGPK(ub)GGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGPEPLQEGPGPKGGR 16 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 16415400.0 5364500.0 5977700.0 5073200.0 True False 7032911.449891897 5085850.460892104 4548273.929570687 1.0 0.7231500776211648 0.6467128104734773 22.745690622033653 -13.999999999999998 0.18057896679278182 2.439006378341508 0.5863562672629499 0.9994974502809333 0.0034022614157965736 12.212293894507049 0.1347160385781803 6.166765727644093 0.05679127283233464 1.0000000000000041e-14 13.999999999999998 -1.852650111078558 SGPEPLQEGPGPK(ub)GGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGPEPLQEGPGPKGGR 16 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 23424700.0 4170000.0 6911700.0 12343000.0 True False 4037625.632542598 9671577.854039347 9109998.017937168 1.0 2.3953627042804615 2.2562760510811315 21.945075719936018 -10.095566196583318 4.956705449902518 0.9999564019689752 2.3258193776872083 0.9918135896102694 0.05678188841716487 2.7358365486645642e-05 4.992138532372856e-06 0.05498062111905863 0.018326275680652277 8.024792350443454e-11 10.095566196583318 1.3258629757182332 SGPEPLQEGPGPK(ub)GGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGPEPLQEGPGPKGGR 16 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 26095700.0 7918400.0 14849000.0 3328300.0 True False 12012791.712582244 12199079.934233457 2670460.0461542853 1.0 1.0155074878603025 0.22230136924435603 23.518068129315523 -6.902441905960316 0.9456973597333044 1.0308055691135984 0.1347845268797542 0.9877426183217974 0.04099925117227666 0.10963023370082295 0.1674542669005824 0.03235974649835737 0.0852747948853979 1.2518667196238096e-07 6.902441905960316 -0.8960210422338443 down SGPEPLQEGPGPK(ub)GGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGPEPLQEGPGPKGGR 16 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 14726700.0 5364500.0 4921800.0 4440400.0 True False 7347900.6201615045 4704338.601783906 3391668.97290862 1.0 0.6402289368035174 0.4615834029657946 22.808900683556544 -13.999999999999869 0.09121186181797766 2.8327273641940054 0.02337998549131167 0.9998366986778807 0.002861392339776239 12.152908912941811 0.08804512368552894 4.301098091976552 0.3932929365971945 1.0000000000003026e-14 13.999999999999869 -2.809347378702694 SGPEPLQEGPGPK(ub)GGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGPEPLQEGPGPKGGR 16 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 18539700.0 4170000.0 8195400.0 6174300.0 True False 3467539.762322572 8151249.753540467 7465317.583262316 1.0 2.35073000232324 2.152914773863189 21.725480995370294 -10.250949695982646 5.556359658637379 0.9999137957170856 2.25182238809324 0.9816161288942278 0.08075772884669326 8.624920513227605e-05 1.1627173705076673e-05 0.07819862251651688 0.02606444490837499 5.611129655796209e-11 10.250949695982646 1.2519085923761544 SGPEPLQEGPGPK(ub)GGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGPEPLQEGPGPKGGR 16 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 22171100.0 7918400.0 10965000.0 3287700.0 True False 10250524.894999223 10354788.11099035 2689372.3346507293 1.0 1.0101715001972233 0.262364353259876 23.289194451407973 -6.903817255016856 0.9368160485216876 1.0279193022364688 0.17748810195476172 0.9883717095266199 0.037757927826105105 0.10864989719192912 0.16199527942840866 0.029997485026605132 0.07965495825173775 1.2479085060520285e-07 6.903817255016856 -0.850431200281707 down SGPFGQIFRPDNFVFGQSGAGNNWAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGPFGQIFRPDNFVFGQSGAGNNWAK 26 1 P04350;M0QZL7;M0R278;M0R1I1;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1;M0QY85 P04350;P07437;P68371;Q13885;Q9BVA1;M0QY85 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 318991130.0 109511860.0 89736500.0 119742770.0 False True 143571108.97436085 76348163.99013731 107352936.81415638 1.0 0.5317794404149353 0.7477335626997743 27.097190221819105 -10.06192927696587 4.852975667823332 1.000009138108161 0.6397565015541345 0.7876989176672746 0.08816290125763411 122275349.83365522 9.378749129076764 13795.020451704835 0.03018050609372602 8.671030683580144e-11 10.06192927696587 -0.3602526365540265 SGPFGQIFRPDNFVFGQSGAGNNWAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGPFGQIFRPDNFVFGQSGAGNNWAK 26 1 P04350;M0QZL7;M0R278;M0R1I1;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1;M0QY85 P04350;P07437;P68371;Q13885;Q9BVA1;M0QY85 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 1075547200.0 13083900.0 425554300.0 636909000.0 False True 12668558.75626478 595480351.2263573 470083426.03956455 1.0 47.004585342581606 37.106306651267786 23.594749069238024 -9.856145421251512 9.487271921664753 1.0007207818152928 42.055445996924696 0.958225911280237 4.0409553756913255 0.0 9.880313926737181e-17 3.912639315479589 1.3042127361743177 1.3926903897183649e-10 9.856145421251512 41.0547252151094 SGPFGQIFRPDNFVFGQSGAGNNWAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGPFGQIFRPDNFVFGQSGAGNNWAK 26 1 P04350;M0QZL7;M0R278;M0R1I1;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1;M0QY85 P04350;P07437;P68371;Q13885;Q9BVA1;M0QY85 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 1283865000.0 425331000.0 507646000.0 350888000.0 False True 645258222.8612255 417052605.04369867 281534833.00032586 1.0 0.6463344290203542 0.43631343704840325 29.26530138054875 -9.367460858442877 0.12739391320469448 1.6190848144126493 1.543967264238775e-06 0.9998883486463943 0.0024577806424439562 0.8122508360578884 0.04776882028903662 0.38338212554059886 0.2045582798754861 4.290808591664282e-10 9.367460858442877 -1.619083270445385 SGPFGQIFRPDNFVFGQSGAGNNWAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGPFGQIFRPDNFVFGQSGAGNNWAK 26 1 P04350;M0QZL7;M0R278;M0R1I1;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1;M0QY85 P04350;P07437;P68371;Q13885;Q9BVA1;M0QY85 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 630613860.0 109511860.0 140548600.0 380553400.0 False True 150001354.088739 134338698.11993274 290674524.6632924 1.0 0.8955832361383856 1.937812671286506 27.160400283341996 -6.882238151883971 1.0671957159601684 0.9331443705969822 2.014932530234368 0.9754481486537372 0.07343183820708635 0.12566787575261296 0.26043984730165054 0.052891653295847246 0.12866950306705793 1.3114805318064956e-07 6.882238151883971 1.0817881596373857 SGPFGQIFRPDNFVFGQSGAGNNWAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGPFGQIFRPDNFVFGQSGAGNNWAK 26 1 P04350;M0QZL7;M0R278;M0R1I1;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1;M0QY85 P04350;P07437;P68371;Q13885;Q9BVA1;M0QY85 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 877055500.0 13083900.0 293172000.0 570799600.0 False True 10879842.565048521 291592624.24591446 690151157.2808399 1.0 26.801180486072045 63.43392867631647 23.3751543446723 -7.19362773998229 0.40814649772523304 9.584977927631183e-18 83.24261244257717 0.9989504437259598 0.8298806368031648 0.13560921825369363 0.039888254191090725 1.1100840698258507 5.506572365410445 6.40283425910729e-08 7.19362773998229 83.24261244257717 SGPFGQIFRPDNFVFGQSGAGNNWAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGPFGQIFRPDNFVFGQSGAGNNWAK 26 1 P04350;M0QZL7;M0R278;M0R1I1;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1;M0QY85 P04350;P07437;P68371;Q13885;Q9BVA1;M0QY85 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 0 1169387000.0 425331000.0 387819000.0 356237000.0 False True 550599364.0274453 366236531.72970015 291405521.30029297 1.0 0.6651597434672021 0.5292514672896852 29.0364277026412 -13.999999999952143 0.12411948400286307 2.5922948051387733 0.323902428741907 0.9996729911880814 0.0035772427683726927 11.94981576551806 0.1089344744148276 4.669790261981125 0.182320220254371 1.0000000001101944e-14 13.999999999952143 -2.268392376396866 SGPLFNFDVHDDVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGPLFNFDVHDDVR 14 0 Q14320;B0S8I6 Q14320 FAM50A Protein FAM50A 0 7150100.0 2198400.0 1859800.0 3091900.0 False True 2882123.689335881 1582325.0894436194 2771979.8475990696 1.0 0.5490135955297012 0.9617837908399444 21.458700820923696 -10.430590928368758 8.759431802999506 1.0000025162792832 0.7553986931848228 0.31889799017304965 0.16851272658984162 8.280804983554092e-06 5.382068956189226e-07 0.16316342311519705 0.054387248642205024 3.710300386872399e-11 10.430590928368758 -0.24460382309446038 SGPLFNFDVHDDVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGPLFNFDVHDDVR 14 0 Q14320;B0S8I6 Q14320 FAM50A Protein FAM50A 0 6300500.0 2570500.0 2161700.0 1568300.0 False True 2488900.8845205605 3024878.0831165765 1157515.1820084946 1.0 1.2153469436768116 0.4650708227103499 21.247077348354317 -6.829957994913419 1.328015939785607 1.1150732107967112 0.4448875007281014 0.9058023811104545 0.09680915204339859 0.18086573531472538 0.6238437439508167 0.0572351934880888 0.13172020660041983 1.4792514548734352e-07 6.829957994913419 -0.6701857100686097 down SGPLFNFDVHDDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGPLFNFDVHDDVR 14 0 Q14320;B0S8I6 Q14320 FAM50A Protein FAM50A 0 7582800.0 2198400.0 1884400.0 3500000.0 False True 3011207.889526151 1801140.977122515 2673372.0847626724 1.0 0.598145675490358 0.8878072131988731 21.521910882446587 -10.417476920874428 5.400259681977503 1.0001837371727027 0.742976444344613 0.5121454313411007 0.11825382758264433 0.0002617801150481538 2.8237936402689138e-05 0.11458002504366512 0.03816625873773739 3.824045747284206e-11 10.417476920874428 -0.25720729282808974 SGPQDHVFIYFTDHGSTGILVFPNEDLHVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGPQDHVFIYFTDHGSTGILVFPNEDLHVK 30 0 Q99538;Q99538-2;Q99538-3;G3V4E4 Q99538 LGMN Legumain 0 79706000.0 17401000.0 30056000.0 32249000.0 False True 26398589.18350219 24692271.971400153 25874971.01476118 1.0 0.9353633180833618 0.9801649184696489 24.653957494084953 -10.080112350236783 4.56004143323189 1.0000026974646328 0.9577641182748506 0.5423320481067385 0.018290176773386287 5.016204731598282e-07 1.0119894167777474e-07 0.01771051846911717 0.00590312916941556 8.31548624988352e-11 10.080112350236783 -0.04223857918978213 SGPQDHVFIYFTDHGSTGILVFPNEDLHVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGPQDHVFIYFTDHGSTGILVFPNEDLHVK 30 0 Q99538;Q99538-2;Q99538-3;G3V4E4 Q99538 LGMN Legumain 0 55733000.0 17401000.0 16056000.0 22276000.0 False True 22525937.524990097 15162469.485641673 18221996.571061753 1.0 0.6731115838717279 0.8089339922410073 24.425083816177402 -10.265232972090446 5.07361981728194 1.0000484542854386 0.7410227880562716 0.8289871258969463 0.055449266023782876 3.0396907096149095e-05 4.40209219827778e-06 0.05369854836389643 0.017896173655745907 5.429589894875869e-11 10.265232972090446 -0.259025666229167 SGQDYK(ub)IPIDNMTNEMEQR ddPTM_RPMI8226_Bortezomib_1h_R1 4 SGQDYKIPIDNMTNEMEQR 19 1 Q9NVH2-3;Q9NVH2-2;Q9NVH2;Q9NVH2-4 Q9NVH2-3 INTS7 Integrator complex subunit 7 1 640236400.0 181034600.0 240803900.0 218397900.0 True False 237338113.74156025 204876896.76625043 195800180.32858658 1.0 0.8632279642592207 0.8249841428410242 27.822368558284808 -13.999999996365377 0.1787734003280742 1.7070093359354668 0.7942172669077877 0.9994996629751302 0.0016804987973045068 12.18911896596116 0.13402399051612782 2.992637154499992 0.028854697601084067 1.0000000083690294e-14 13.999999996365377 -0.9127920690276791 SGQDYK(ub)IPIDNMTNEMEQR ddPTM_RPMI8226_Bortezomib_2h_R1 4 SGQDYKIPIDNMTNEMEQR 19 1 Q9NVH2-3;Q9NVH2-2;Q9NVH2;Q9NVH2-4 Q9NVH2-3 INTS7 Integrator complex subunit 7 1 724051400.0 207848300.0 239243700.0 276959400.0 True False 201250269.48690715 334774957.0494135 204415424.53609848 1.0 1.6634758199476256 1.0157274574452049 27.58441547418784 -10.19309328428655 5.041959881884569 0.9999709899170203 1.3396016386967493 0.2681996723002684 0.2644421616435945 8.624731995420375e-05 1.3803474907272218e-05 0.2560668677042841 0.08534834067322027 6.410718627599243e-11 10.19309328428655 0.33963064877972904 SGQDYK(ub)IPIDNMTNEMEQR ddPTM_RPMI8226_Bortezomib_8h_R1 4 SGQDYKIPIDNMTNEMEQR 19 1 Q9NVH2-3;Q9NVH2-2;Q9NVH2;Q9NVH2-4 Q9NVH2-3 INTS7 Integrator complex subunit 7 1 1045260400.0 379666000.0 400487000.0 265107400.0 True False 575981079.3025424 329016965.83078706 212708806.189299 1.0 0.5712287740930568 0.3692982527253653 29.101446179716607 -12.608838290718117 0.11510890062280484 2.5310488882142717 7.140976198664951e-23 0.9997643219938295 0.004037146438235162 7.208823229730068 0.0892791936772253 2.8690114333374983 0.2944430876595033 2.461283891083039e-13 12.608838290718117 -2.5310488882142717 SGQDYK(ub)IPIDNMTNEMEQR ddPTM_RPMI8226_Carfilzomib_1h_R1 4 SGQDYKIPIDNMTNEMEQR 19 1 Q9NVH2-3;Q9NVH2-2;Q9NVH2;Q9NVH2-4 Q9NVH2-3 INTS7 Integrator complex subunit 7 1 578903100.0 181034600.0 210636300.0 187232200.0 True False 247967983.89611155 201329691.7849027 143011810.52820036 1.0 0.8119180896726232 0.576734981190622 27.8855786198077 -6.968104649907917 0.3000236961399833 1.0407771349886898 0.34050640962598916 0.9999635938447936 0.0010447491416381745 0.07692261800559669 0.011219710227313696 0.0039012997741009595 0.021091986367150983 1.0762058540969481e-07 6.968104649907917 -0.7002707253627007 SGQDYK(ub)IPIDNMTNEMEQR ddPTM_RPMI8226_Carfilzomib_2h_R1 4 SGQDYKIPIDNMTNEMEQR 19 1 Q9NVH2-3;Q9NVH2-2;Q9NVH2;Q9NVH2-4 Q9NVH2-3 INTS7 Integrator complex subunit 7 1 701715400.0 207848300.0 316211900.0 177655200.0 True False 172835070.69092327 314508403.73155206 214802080.93516377 1.0 1.8197024624358777 1.2428153619313123 27.364820749622115 -10.088768374898478 5.443372013220547 0.9999941772509037 1.5312589121838582 0.5306833715820657 0.23551317257256893 1.6642736857029438e-05 2.785428497848342e-06 0.2280371450924095 0.07601154959870204 8.151389114480771e-11 10.088768374898478 0.5312647349329546 SGQDYK(ub)IPIDNMTNEMEQR ddPTM_RPMI8226_Carfilzomib_8h_R1 4 SGQDYKIPIDNMTNEMEQR 19 1 Q9NVH2-3;Q9NVH2-2;Q9NVH2;Q9NVH2-4 Q9NVH2-3 INTS7 Integrator complex subunit 7 1 934340400.0 379666000.0 419504200.0 135170200.0 True False 491485121.33572143 396158422.4961712 110570610.56337455 1.0 0.806043571409693 0.22497244731005087 28.872572501809056 -6.958812456802905 0.5451750149788999 1.0081533171490873 1.8524279684206527e-18 0.9993157628359028 0.008613733137071398 0.08156973026034905 0.03357938174506786 0.009451101170361142 0.047304748471700575 1.0994805301934024e-07 6.958812456802905 -1.0081533171490873 down SGQGAFGNMCR ddPTM_RPMI8226_Bortezomib_1h_R1 2 SGQGAFGNMCR 11 0 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 38409400.0 6578500.0 18452500.0 13378400.0 False True 8624477.20628463 15699458.927281661 11994131.502674526 1.0 1.8203374595090256 1.390708238400171 23.040005576275107 -10.150295375105854 4.33819994459211 0.9999087136142191 1.605522848305775 0.7259203475841387 0.17539539622892555 163597774.89693153 112123207.16780473 229603.12733390907 0.06418813961795448 7.074644555269392e-11 10.150295375105854 0.605614134691556 SGQGAFGNMCR ddPTM_RPMI8226_Bortezomib_2h_R1 2 SGQGAFGNMCR 11 0 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 16430550.0 8068500.0 3438800.0 4923250.0 False True 7812369.883973599 4811930.773105097 3633703.130665892 1.0 0.6159373973032635 0.465121747258808 22.897328825914677 -13.999999999999998 0.12917743072841206 2.8250067965551073 0.25169171864883105 0.999649355776909 0.004216556698027632 11.938068799905418 0.11168674345423996 5.535931371559505 0.18975381283700707 1.0000000000000041e-14 13.999999999999998 -2.573315077906276 SGQGAFGNMCR ddPTM_RPMI8226_Bortezomib_8h_R1 2 SGQGAFGNMCR 11 0 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 114997300.0 14783100.0 90356000.0 9858200.0 False True 22427043.48937598 74231265.84534976 7909722.448997439 1.0 3.3098997592132107 0.35268681102546534 24.418736109675894 -6.698307641177199 1.8369312732788208 2.4367328309353584 0.36176665131067703 0.4095314829999034 0.9753433353811661 0.39905657015724827 2.616684045204078 0.42378572617813437 1.0921369167977744 2.0030526223292857e-07 6.698307641177199 -2.074966179624681 SGQGAFGNMCR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SGQGAFGNMCR 11 0 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 39488300.0 6578500.0 16557100.0 16352700.0 False True 9010749.22727794 15825552.574992105 12490529.054428153 1.0 1.756297082054391 1.3861809644658616 23.103215637797998 -10.215205029257119 4.64741432495689 0.9998713179954442 1.571239023263451 0.7605439391703658 0.1510992722904661 0.0002015222320112542 3.403042818564596e-05 0.14633391527630651 0.04876708043208179 6.092492044248303e-11 10.215205029257119 0.5713677052680068 SGQGAFGNMCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGQGAFGNMCR 11 0 P36578;H3BTP7;H3BU31 P36578 RPL4 60S ribosomal protein L4 0 10020500.0 4918400.0 2634800.0 2467300.0 False True 6366965.756158346 2488171.0638246564 2018276.7166358675 1.0 0.3907938504958995 0.31699192267269877 22.602174574231743 -13.999999999999998 0.2977494545302772 6.485718203882746 0.2984060802409612 0.9996448053039546 0.005768273865437485 16.44329951767421 0.17323126238581274 55.500476300029746 0.02693229935560411 1.0000000000000041e-14 13.999999999999998 -6.187312123641784 SGQKPVLDVHAELDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGQKPVLDVHAELDR 15 1 Q9Y6G9;E9PHI6 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 0 7791500.0 1292500.0 4501600.0 1997400.0 False True 1694480.0165878034 3829978.8270993703 1790728.208413718 1.0 2.260267922670371 1.0568010191231 20.692411192195255 -6.6353822754275456 2.0612811438208563 1.827011344096596 1.0617621191633626 0.1371205547585983 0.5398570213344778 0.545085747722059 4.42053603186699 0.2137140733951664 0.5977876356881013 2.315355726392097e-07 6.6353822754275456 -0.7652492249332334 SGQKPVLDVHAELDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGQKPVLDVHAELDR 15 1 Q9Y6G9;E9PHI6 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 0 3804600.0 901720.0 877680.0 2025200.0 False True 873095.3921765735 1228142.2010407352 1494739.3653023043 1.0 1.4066529408419528 1.7120000617298075 19.735779762085002 -6.974285425451768 0.11692233058466446 0.4240588542635704 2.7024230641241958 0.9999995054036294 0.00020503036308317776 0.07493511518396087 0.003473582864900512 0.0222998557482399 0.04480212758184181 1.0609980227175706e-07 6.974285425451768 2.2783642098606256 SGQKPVLDVHAELDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGQKPVLDVHAELDR 15 1 Q9Y6G9;E9PHI6 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 0 27079100.0 6128000.0 18191100.0 2760000.0 False True 9296624.016809473 14944756.077286968 2214484.790249024 1.0 1.6075465728489136 0.2382031139739496 23.148275479260843 -6.786093610396 1.5119048546251477 1.3412878619313353 0.2251647692588843 0.7884268730743076 0.2576816792611398 0.241220506179826 1.0893278345983393 0.134184718218611 0.31507638726220066 1.6364637503542156e-07 6.786093610396 -1.116123092672451 SGQKPVLDVHAELDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGQKPVLDVHAELDR 15 1 Q9Y6G9;E9PHI6 Q9Y6G9 DYNC1LI1 Cytoplasmic dynein 1 light intermediate chain 1 0 3559400.0 1292500.0 1197800.0 1069100.0 False True 1770372.178499159 1144877.2354050872 816600.5988056492 1.0 0.6466873176778355 0.4612592813664334 20.755621253718147 -12.419610756207643 0.09535100834915206 2.3651843972810473 4.695354859526826e-13 0.9998640778454985 0.002605348940628863 6.771246027060072 0.07463678078999306 2.1844563688142227 0.35813877369195224 3.805303002603242e-13 12.419610756207643 -2.365184397280578 SGQVYSFGCNDEGALGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGQVYSFGCNDEGALGR 17 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 18913400.0 2921400.0 7703800.0 8288200.0 False True 3829983.690877841 6554423.069177206 7430616.570028339 1.0 1.7113449033186137 1.9401170265362735 21.86890681809588 -10.85191127171476 0.22573023454737787 1.402540334455196e-09 2.082738391721975 0.9992741541701368 0.01078471929165121 2.756231303578235 0.11994893225396679 1.5851217093235477 0.1200846847733699 1.4063348152099737e-11 10.85191127171476 2.0827383903194345 SGQVYSFGCNDEGALGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGQVYSFGCNDEGALGR 17 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 34442400.0 3086200.0 27348000.0 4008200.0 False True 4681991.031442129 22467535.72910072 3215977.513143528 1.0 4.798713961265396 0.6868824590962437 22.15869074023152 -6.663904468697264 1.958916520649638 3.4372376440041643 0.7038194845148915 0.2524303303472045 1.6158992342004868 0.47522118444805067 3.509526349654421 0.6654891551903878 1.7923157761389064 2.1681809848708152e-07 6.663904468697264 -2.733418159489273 SGQVYSFGCNDEGALGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGQVYSFGCNDEGALGR 17 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 15723300.0 2921400.0 7648800.0 5153100.0 False True 4001520.5278664944 7310850.724800818 3936043.9114258583 1.0 1.827018173188973 0.9836370659641358 21.93211687961877 -10.352584546071018 3.4088350673658043 0.9974872683430774 1.4053276195789879 0.23545438433022092 0.3443088968341753 52108390.48488394 73984222.60203736 1301697.771325688 0.1208702908188605 4.440332109975628e-11 10.352584546071018 0.40784035123591045 SGQVYSFGCNDEGALGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGQVYSFGCNDEGALGR 17 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 6502400.0 3086200.0 0.0 3416200.0 False True 3995146.738096918 0.0 2794486.6531720744 1.0 0.0 0.6994703414831827 21.92981706232397 -10.523277710389811 8.460942042472691 1.0000601964113365 0.3497351732011552 0.5353894016652809 0.2855575711406838 0.0003242833257583029 1.8271132339907094e-05 0.27651514237252717 0.09216330978427564 2.997245312151162e-11 10.523277710389811 -0.6503250232101813 SGSGTMNLGGSLTR ddPTM_RPMI8226_Bortezomib_1h_R1 2 SGSGTMNLGGSLTR 14 0 P47756-2;B1AK88;B1AK87;P47756;B1AK85 P47756-2 CAPZB F-actin-capping protein subunit beta 0 130033400.0 32031600.0 41215100.0 56786700.0 False True 41993737.794455685 35065967.73520153 50910957.02049039 1.0 0.8350284965543409 1.2123464043539374 25.32367087004413 -6.787838889978286 1.5047477128880362 0.907540040765219 1.216136424374363 0.7943349763457178 0.07004063911216418 0.2385739219458682 1.0671701891790943 0.03664080362950906 0.08592976751470505 1.629900563954653e-07 6.787838889978286 0.3085963836091441 SGSGTMNLGGSLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGSGTMNLGGSLTR 14 0 P47756-2;B1AK88;B1AK87;P47756;B1AK85 P47756-2 CAPZB F-actin-capping protein subunit beta 0 8518600.0 1734800.0 881400.0 5902400.0 False True 1679729.7235815104 1233347.6164402785 4356384.371795542 1.0 0.7342536118313973 2.59350317532447 20.679797684579732 -6.870664534923806 1.1306543395217092 0.8491003142050007 2.703736282283494 0.9653378798709773 0.15285580556134923 0.13621511599811176 0.3250632872201236 0.10488205287892928 0.2485883781198014 1.3469003478467532e-07 6.870664534923806 1.8546359680784934 up SGSGTMNLGGSLTR ddPTM_RPMI8226_Bortezomib_8h_R1 2 SGSGTMNLGGSLTR 14 0 P47756-2;B1AK88;B1AK87;P47756;B1AK85 P47756-2 CAPZB F-actin-capping protein subunit beta 0 92589800.0 17697400.0 58485300.0 16407100.0 False True 26848249.65324475 48048141.26726546 13164229.493512621 1.0 1.7896191330096112 0.49031984071712686 24.6783247003218 -6.742188489344805 1.6785572922933565 1.4686193668821865 0.4891678921958365 0.6147933499692589 0.3317529172994917 0.3138640603140963 1.737177327723796 0.1562979843643063 0.3826424689944772 1.8105541184885276e-07 6.742188489344805 -0.9794514746863501 SGSGTMNLGGSLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SGSGTMNLGGSLTR 14 0 P47756-2;B1AK88;B1AK87;P47756;B1AK85 P47756-2 CAPZB F-actin-capping protein subunit beta 0 91802900.0 32031600.0 26218800.0 33552500.0 False True 43874548.14144198 25060366.72202277 25628090.53542841 1.0 0.5711823319805737 0.5841220393383662 25.38688093156702 -9.863376750522821 5.416528561564125 1.0000002945221285 0.5776521856683692 0.9992964992619746 0.005282613421838979 7182013.776318556 1.1745212893666308 26.38246029190921 0.0018083790814389649 1.3696930417278912e-10 9.863376750522821 -0.4223481088537593 SGSGTMNLGGSLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SGSGTMNLGGSLTR 14 0 P47756-2;B1AK88;B1AK87;P47756;B1AK85 P47756-2 CAPZB F-actin-capping protein subunit beta 0 38623700.0 16715800.0 12006900.0 9901000.0 False True 13899928.335499186 11942216.446516957 11971253.322948378 1.0 0.8591566919102449 0.861245686596445 23.728574109010214 -10.004193375407361 4.7763316655227275 1.0000024501956422 0.860201189248906 0.9998325534623461 0.0008528285246958815 2.225169949374411e-08 4.6385403858355595e-09 0.0008257621377936787 0.000275249220608698 9.903908619674896e-11 10.004193375407361 -0.13980126094673617 SGSGTMNLGGSLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SGSGTMNLGGSLTR 14 0 P47756-2;B1AK88;B1AK87;P47756;B1AK85 P47756-2 CAPZB F-actin-capping protein subunit beta 0 63370400.0 17697400.0 27124600.0 18548400.0 False True 22909633.167907584 25615092.16556029 15172781.522655856 1.0 1.1180926371812265 0.6622882789721088 24.449451022414248 -6.8379180408912825 1.2920497078782358 1.062849038325266 0.6479056743219339 0.9208123236153388 0.05435222076570622 0.1712438956682942 0.5562129544144317 0.03299692083550422 0.07598054162999246 1.4523856827891484e-07 6.8379180408912825 -0.4149433640033321 SGSHTVAVMNVGAPAAGMNAAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGSHTVAVMNVGAPAAGMNAAVR 23 0 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 0 25123500.0 5799800.0 9185700.0 10138000.0 False True 7603593.965343088 7815229.365578153 9089017.010562878 1.0 1.0278336009523512 1.1953580177992533 22.85825006293265 -6.935767754699415 0.6978162688493926 0.997913309075731 1.2354151336006975 0.9975554983275478 0.004266026428384901 0.08975124527307958 0.06380394850289856 0.0040299012165340336 0.014707216115156272 1.159397194945431e-07 6.935767754699415 0.2375018245249666 SGSHTVAVMNVGAPAAGMNAAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGSHTVAVMNVGAPAAGMNAAVR 23 0 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 0 19550700.0 8076400.0 2853200.0 8621100.0 False True 7820019.102797853 3992497.63924144 6362975.282543797 1.0 0.510548323061385 0.8136777159875794 22.898740701086734 -10.379577301638065 6.196436684793681 1.0000483461048488 0.6621130195244838 0.623583277696156 0.12375205645146772 8.266451612744988e-05 8.276832429618864e-06 0.11983950011026756 0.039940804474621165 4.1727531951883244e-11 10.379577301638065 -0.33793532658036507 SGSHTVAVMNVGAPAAGMNAAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGSHTVAVMNVGAPAAGMNAAVR 23 0 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 0 58602600.0 8547400.0 40394000.0 9661200.0 False True 12967030.698641853 33185375.1002375 7751659.585345605 1.0 2.5592115783078455 0.5977975810728591 23.628344820996446 -6.694877044853136 1.8488287182152927 1.973002831061344 0.6040987204187489 0.39346640612194994 0.6587958819762959 0.40626632074282215 2.6959793836392842 0.2846504387152768 0.7367952599353176 2.0189378737430692e-07 6.694877044853136 -1.3689041106425952 SGSHTVAVMNVGAPAAGMNAAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGSHTVAVMNVGAPAAGMNAAVR 23 0 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 0 22169800.0 5799800.0 6521300.0 9848700.0 False True 7944142.79370168 6233167.402944727 7522639.900343463 1.0 0.7846242904755616 0.9469416771193494 22.921460124455542 -10.26344529143025 5.763912192249394 1.0000076272962897 0.8657829838729972 0.47688920482190844 0.06626579560989318 6.495395638152867e-06 8.300439015221951e-07 0.06416522576853274 0.021387193568357676 5.451985706472144e-11 10.26344529143025 -0.13422464342329243 SGSHTVAVMNVGAPAAGMNAAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGSHTVAVMNVGAPAAGMNAAVR 23 0 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 0 13998900.0 8076400.0 2944600.0 2977900.0 False True 6715884.445185139 2928736.8553426648 3600565.1217460837 1.0 0.43609101366274733 0.5361267233130342 22.67914597652101 -10.28228535997372 7.275067406202931 1.0000030863745568 0.48610886848814083 0.972365062479207 0.04083940745006899 2.0443945848232903e-06 2.0171580000886978e-07 0.039542823290075337 0.013180862076924696 5.220530531661856e-11 10.28228535997372 -0.513894217886416 SGSHTVAVMNVGAPAAGMNAAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGSHTVAVMNVGAPAAGMNAAVR 23 0 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0 A0A2R8Y891 PFKM ATP-dependent 6-phosphofructokinase, muscle type 0 33321400.0 8547400.0 11880000.0 12894000.0 False True 11064777.79444288 11218867.556640688 10547424.303612411 1.0 1.0139261506250217 0.9532432100814259 23.399471143088896 -6.846328145606145 1.2525727200188688 1.0074148003466263 0.950982526865877 0.9347995592203154 0.006627224450732215 0.16154786597275678 0.4895752820554887 0.004143573667228428 0.009569252691081463 1.4245308353231494e-07 6.846328145606145 -0.056432273480749306 SGSKFPVFNMSYNPAENAVLLCTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGSKFPVFNMSYNPAENAVLLCTR 24 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 32464200.0 5343700.0 8610500.0 18510000.0 False True 8106783.57679908 7073889.00085644 14851490.386778802 1.0 0.8725888552275287 1.8319830850403476 22.95069819791975 -6.873445626947868 1.1157729357798465 0.9262058874137211 1.8919589827414107 0.9679995242527367 0.0761026429503167 0.13359074963192344 0.3087620348596301 0.052816999065073415 0.12584426139412286 1.3383027582697287e-07 6.873445626947868 0.9657530953276896 SGSLENVPNVGVNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGSLENVPNVGVNK 14 0 P53004 P53004 BLVRA Biliverdin reductase A 0 17256000.0 1191500.0 6693200.0 9371300.0 False True 1562068.0385024147 5694600.649889259 8401647.771857154 1.0 3.645552248382717 5.378541500607091 20.57502586318323 -8.25920341824906 0.2696459298550396 4.794931486202314e-16 6.634359366684376 0.9992518218601921 0.049246790263427445 0.09803325988592967 0.06375653259989351 0.540940646493552 0.5846697680414858 5.505497651955133e-09 8.25920341824906 6.634359366684375 SGSLENVPNVGVNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGSLENVPNVGVNK 14 0 P53004 P53004 BLVRA Biliverdin reductase A 0 16748000.0 5052900.0 2664100.0 9031000.0 False True 4892498.455317619 3727889.023097966 6665510.175807389 1.0 0.7619601839722916 1.3623939254518715 22.222139964681933 -6.799128234604426 1.4593463957073134 0.8685159304453101 1.37051677773558 0.829633337818626 0.10189773025040026 0.22200544797770974 0.9334991830541963 0.05493129305722061 0.12782537485250994 1.588077765912017e-07 6.799128234604426 0.50200084729027 SGSLENVPNVGVNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGSLENVPNVGVNK 14 0 P53004 P53004 BLVRA Biliverdin reductase A 0 16117100.0 1191500.0 7732300.0 7193300.0 False True 1632029.7490767904 7390661.418703259 5494390.690663801 1.0 4.528509007194276 3.3665995940159044 20.638235924706123 -9.693210077516834 8.938501643945878 0.9999981752499604 3.9475543006557072 0.89562243982826 0.47434753160511123 0.0 0.0 0.45928502255476905 0.15309500751825633 2.026702123268109e-10 9.693210077516834 2.9475561254057467 SGSLENVPNVGVNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGSLENVPNVGVNK 14 0 P53004 P53004 BLVRA Biliverdin reductase A 0 10571100.0 3483100.0 3362300.0 3725700.0 False True 4508941.6121655665 3175185.0493007586 3047660.8289102525 1.0 0.7041974197966543 0.675914902221702 22.1043573974667 -13.999999999999998 0.33199705982989985 4.259033608977093 0.671022439632173 0.9997189710058431 0.0024569876938343852 18.993524834390698 0.18436209276259682 43.26691092760276 0.008996273496987632 1.0000000000000041e-14 13.999999999999998 -3.58801116934492 SGSLENVPNVGVNK(ub)NIFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGSLENVPNVGVNKNIFLK 19 1 P53004 P53004 BLVRA Biliverdin reductase A 1 15359100.0 6668200.0 4894400.0 3796500.0 True False 5544903.7513475735 4868032.895737662 4590330.596967321 1.0 0.877929196616729 0.8278467585396295 22.402730987572532 -13.999999999999986 0.12246203116371535 1.5809149205678736 0.7505008878718119 0.9996809456617767 0.001291425426776756 11.955000035668926 0.10800906009901182 1.6849267174757356 0.06865325333235524 1.0000000000000327e-14 13.999999999999986 -0.8304140326960617 SGSLENVPNVGVNK(ub)NIFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGSLENVPNVGVNKNIFLK 19 1 P53004 P53004 BLVRA Biliverdin reductase A 1 26725300.0 7908200.0 4745100.0 14072000.0 True False 10237320.793927182 4481031.013721867 11511040.390913134 1.0 0.4377152092742891 1.1244192325927238 23.287334861672406 -6.689007310827466 1.8694300533142874 0.6471763195118332 1.1220563966655954 0.3660902605496953 0.23785162965869489 0.4187615683551379 2.8365098258769934 0.10180200228914711 0.2654818447250996 2.0464101875701137e-07 6.689007310827466 0.47488007715376224 SGSLSLTQFADMISLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGSLSLTQFADMISLK 16 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 33568600.0 7858600.0 14787000.0 10923000.0 False True 11922070.74061666 12148144.31864168 8764064.262279019 1.0 1.018962610014955 0.7351125868110479 23.507131503011546 -6.89092235017873 1.0169307587376983 1.0149161050316637 0.7102549335922375 0.9814813926237004 0.01763230218362442 0.11839716853391521 0.21751180938491044 0.01319521576801077 0.033006375324894574 1.285516483729563e-07 6.89092235017873 -0.3046611714394263 SGSLSLTQFADMISLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGSLSLTQFADMISLK 16 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 20861600.0 7858600.0 7398600.0 5604400.0 False True 10173112.61616501 6986861.406107906 4584456.706000107 1.0 0.6867968211622694 0.4506444466873821 23.278257825103996 -7.569938367074321 0.1645857999194961 1.272372217324651 3.9821047249223174e-11 0.9999730501326021 0.0011680734698898377 0.13377344234714184 0.016628352451086424 0.04303264330032326 0.07365064611893274 2.69191680034397e-08 7.569938367074321 -1.27237221728483 down SGSMDPSGAHPSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGSMDPSGAHPSVR 14 0 Q07666;Q07666-2;Q07666-3 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 0 8051440.0 786840.0 3777600.0 3487000.0 False True 1031554.8597693997 3213996.804969472 3126198.689665889 1.0 3.115681899543325 3.0305694942533052 19.97638911746342 -10.295177733762541 4.315029633935816 0.9981157621281038 3.073125696929691 0.9987374543985743 0.034746994064980004 12327155.591130009 706.2289286032733 230863.4563971969 0.01189482026833236 5.067832662418782e-11 10.295177733762541 2.075009934801587 SGSMDPSGAHPSVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGSMDPSGAHPSVR 14 0 Q07666;Q07666-2;Q07666-3 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 0 13948000.0 2081500.0 10394000.0 1472500.0 False True 3157787.6780334353 8539109.491307326 1181459.7295803218 1.0 2.7041430146517 0.37414159849914147 21.5904827404761 -6.710615671694808 1.7927415658301327 2.046991544157351 0.3794514957832768 0.4681409890927828 0.718046343858602 0.3738437282179128 2.3424500659355325 0.31867363556707073 0.8090583527690585 1.9470823873182825e-07 6.710615671694808 -1.667540048374074 SGSMDPSGAHPSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGSMDPSGAHPSVR 14 0 Q07666;Q07666-2;Q07666-3 Q07666 KHDRBS1 KH domain-containing, RNA-binding, signal transduction-associated protein 1 0 7488940.0 786840.0 3171200.0 3530900.0 False True 1077756.0115514742 3031085.898243954 2696974.1411681487 1.0 2.812404538463748 2.502397678381532 20.03959917898631 -10.406202806488416 5.748017069675866 0.9993598656776989 2.6574011084226417 0.9744318047741172 0.12655977066064467 0.001038539293590021 0.00010728599781281649 0.12257940741004049 0.040846990339040795 3.9246162118825795e-11 10.406202806488416 1.6580412427449427 SGSSFVHQASFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGSSFVHQASFK 12 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 0 3163780.0 630280.0 1088800.0 1444700.0 False True 826303.1836402019 926355.28410916 1295216.3025409533 1.0 1.1210840069963035 1.5674831323231724 19.656311700729994 -6.946751178733958 0.5934494742239622 0.9948906011118915 1.7162718553278764 0.998920962903428 0.008016177278162999 0.08481731337797951 0.04156938428524356 0.008281408527830108 0.037436286133257175 1.1304433965255735e-07 6.946751178733958 0.7213812542159849 SGSSFVHQASFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGSSFVHQASFK 12 0 P49792 P49792 RANBP2 E3 SUMO-protein ligase RanBP2 0 2802120.0 630280.0 668640.0 1503200.0 False True 863311.5486765573 639097.2739032035 1148175.1193757858 1.0 0.7402857924035992 1.3299661299978205 19.719521762252885 -6.786971535733844 1.5082864652581176 0.8542729763697682 1.3357360592478646 0.7914061145074113 0.11020891585909505 0.23989351067645756 1.0781408592221062 0.0575228803840714 0.13498542526670648 1.633158983904604e-07 6.786971535733844 0.48146308287809647 SGTLLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGTLLLR 7 0 H0YD05;Q86WG5 H0YD05 SBF2 Myotubularin-related protein 13 0 6919500.0 1914900.0 2031200.0 2973400.0 False True 2510452.443917979 1728152.877555588 2665741.0908668065 1.0 0.6883830369869575 1.0618568367327739 21.25951596528254 -6.685268459671529 1.8829623734734708 0.8037809296264212 1.06050732800673 0.348510342789519 0.1319205509226925 0.426910585729216 2.9307374362096046 0.05612253818054265 0.14703901720150142 2.0641038330317204e-07 6.685268459671529 0.25672639838030886 SGTLLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGTLLLR 7 0 H0YD05;Q86WG5 H0YD05 SBF2 Myotubularin-related protein 13 0 6014000.0 1653400.0 1095700.0 3264900.0 False True 1600913.7220254028 1533218.7240000153 2409724.7450994947 1.0 0.9577147743229142 1.50521837120043 20.61046412817139 -6.888252824612904 1.0326848388582965 0.9693379072714455 1.5507240776192037 0.9797554210272721 0.035389980376528164 0.12057128591127725 0.23023094425682222 0.02617025937089995 0.0648443926868305 1.2934426443598843e-07 6.888252824612904 0.5813861703477582 SGTLLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGTLLLR 7 0 H0YD05;Q86WG5 H0YD05 SBF2 Myotubularin-related protein 13 0 8052500.0 1914900.0 2139200.0 3998400.0 False True 2622890.2782267258 2044683.0706115912 3054060.269632873 1.0 0.779553413875152 1.1643873535181393 21.32272602680543 -6.751329577806267 1.6447670067330156 0.8705843055023835 1.1652380562431595 0.6547439127440657 0.0926400901582198 0.29772794605862524 1.5850569624282924 0.044484730496102985 0.1078532401399172 1.7728435930515274e-07 6.751329577806267 0.29465375074077593 SGTSEFLNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGTSEFLNK 9 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 43648100.0 4783100.0 23054000.0 15811000.0 False True 6270690.419606295 19614433.063788168 14175029.38982142 1.0 3.12795430028894 2.2605213208263275 22.58019286563784 -10.528439056545864 6.174230490468086 0.9979229874172585 2.6942378105571905 0.8357008781419447 0.35412803095758777 0.01012849131513247 0.0007735691828122491 0.3430025528635888 0.11429433052699661 2.961835563181225e-11 10.528439056545864 1.6963148231399319 SGTSEFLNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGTSEFLNK 9 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 43540800.0 11230000.0 5742800.0 26568000.0 False True 10873509.79699121 8035929.988306363 19609043.777084544 1.0 0.7390373612878862 1.8033775793820068 23.374314358891954 -6.841862890925803 1.273622639623835 0.8611844150496636 1.839715114542043 0.9276202889830929 0.12185480791108312 0.16663766417278814 0.5242490446410975 0.07499572380081708 0.17288063085199545 1.4392528863174991e-07 6.841862890925803 0.9785306994923794 SGTSEFLNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGTSEFLNK 9 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 99587100.0 13554000.0 79581000.0 6452100.0 False True 20562408.930129826 65379148.78080903 5176839.606944107 1.0 3.179547153398444 0.2517623117279101 24.293505953450126 -6.707391422881248 1.8045146016552158 2.343515311084968 0.25917983251759225 0.4526552893061092 0.9188370638136162 0.3803682329760154 2.4127492392510277 0.40545885241391766 1.0333232153737395 1.961591527860211e-07 6.707391422881248 -2.0843354785673758 SGTSEFLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGTSEFLNK 9 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 37851100.0 4783100.0 16615000.0 16453000.0 False True 6551541.328417287 15880894.361542445 12567140.260171503 1.0 2.4239936169919467 1.9181959832355138 22.643402927160732 -9.98372910822854 6.122188734392552 0.9999992973207755 2.1710948001138264 0.8772667054784088 0.2064910193020735 1.980851394017525e-06 3.284766439010336e-07 0.1999341888743325 0.06664468990814344 1.0381757774483601e-10 9.98372910822854 1.171095502793051 SGTSEFLNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGTSEFLNK 9 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 26129800.0 13554000.0 7538200.0 5037600.0 False True 17545920.18928315 7118692.543389643 4120808.490140987 1.0 0.40571782309471915 0.23485849962191951 24.064632275542575 -13.999999999999961 0.17480330961917118 4.036527092506004 0.0915974101644472 0.999505336293838 0.007293361283454359 12.141889604645236 0.13247928576780013 12.509534786460158 0.13343538896743362 1.00000000000009e-14 13.999999999999961 -3.944929682341557 SGTVACSFVQVGGVYSYDCSFGHVPNVELMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGTVACSFVQVGGVYSYDCSFGHVPNVELMK 31 0 A0A1W2PQY2;Q5T011-4;Q5T011-5;Q5T011 A0A1W2PQY2 SZT2 Protein SZT2 0 255018000.0 62406000.0 74892000.0 117720000.0 False True 81814870.34056374 63718405.52672947 105539463.64997663 1.0 0.7788120333320132 1.2899789880575079 26.285859749638107 -6.789108191046309 1.4999413525169436 0.8762354999170845 1.2952795217250137 0.7984144945230941 0.09397747212235705 0.23667970559812743 1.0519722478048563 0.049319225979419894 0.11554151265824254 1.6251438509598576e-07 6.789108191046309 0.4190440218079292 SGTVACSFVQVGGVYSYDCSFGHVPNVELMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGTVACSFVQVGGVYSYDCSFGHVPNVELMK 31 0 A0A1W2PQY2;Q5T011-4;Q5T011-5;Q5T011 A0A1W2PQY2 SZT2 Protein SZT2 0 199419000.0 49623000.0 30606000.0 119190000.0 False True 48047745.027256854 42827135.40818155 87970563.37664503 1.0 0.8913453770595535 1.8308988970604236 25.517965388356597 -6.8781079648220205 1.0903510053889502 0.934211087369476 1.8951009664534137 0.9721245506046132 0.07006462209352714 0.1293167088801067 0.28255617236099595 0.049583107846851944 0.11934386547387203 1.3240123472058662e-07 6.8781079648220205 0.9608898790839377 SGTVACSFVQVGGVYSYDCSFGHVPNVELMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGTVACSFVQVGGVYSYDCSFGHVPNVELMK 31 0 A0A1W2PQY2;Q5T011-4;Q5T011-5;Q5T011 A0A1W2PQY2 SZT2 Protein SZT2 0 200392000.0 48362000.0 81795000.0 70235000.0 False True 62605562.35754106 77243036.34641628 57452950.6719573 1.0 1.233804688236493 0.9176972222347091 25.899787507138406 -6.708525154680936 1.8000404416641311 1.143946550908359 0.9184567575789976 0.45834886311530443 0.0985461416294545 0.3780155893131581 2.38656978754221 0.043578207044375476 0.11092507334976877 1.9564774439273504e-07 6.708525154680936 -0.22548979332936148 SGTVDPQELQK(ub)ALTTMGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGTVDPQELQKALTTMGFR 19 1 C9J0K6;P30626-3;P30626-2;P30626 C9J0K6 SRI Sorcin 1 12220000.0 5392500.0 5128200.0 1699300.0 True False 4484102.678255268 5100573.368731993 2054615.7733245299 1.0 1.1374791646645765 0.45819998353025354 22.096387883086084 -6.8540197378636964 1.2155018984416943 1.0736995805800589 0.4288588714921921 0.9459592998889903 0.06816676234005664 0.15308791706554561 0.4332235435061253 0.04383347584175022 0.10173133583215167 1.39952371541845e-07 6.8540197378636964 -0.6448407090878667 down SGTYLQGTFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGTYLQGTFR 10 0 G3V1J5;Q9Y2L1-2;Q9Y2L1;F2Z2C0 G3V1J5 DIS3 Exosome complex exonuclease RRP44 0 12610000.0 4393300.0 2786100.0 5430600.0 False True 5759658.844777721 2370424.740132743 4868693.605993568 1.0 0.41155644874383585 0.8453093728646809 22.457551930032817 -9.791729996155745 6.145858390302322 1.0000000139373713 0.62843291080387 0.4945479165174679 0.1770788897575132 3.378958909203538e-08 6.85920790143834e-09 0.17145590413550996 0.057151965916095594 1.6153625266173208e-10 9.791729996155745 -0.3715671031335013 SGTYLQGTFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGTYLQGTFR 10 0 G3V1J5;Q9Y2L1-2;Q9Y2L1;F2Z2C0 G3V1J5 DIS3 Exosome complex exonuclease RRP44 0 5857500.0 4393300.0 1464200.0 0.0 False True 6017621.734468367 1399506.8025380934 0.0 1.0 0.23256809156379024 0.0 22.52076199155571 -9.192731285340589 0.4629165960330679 1.145221826190881 6.843022835912777e-21 0.9969078866014152 0.02375912601534537 0.6542536067238143 0.20333880926011458 0.2326412456547159 0.05101173490535818 6.416064403175321e-10 9.192731285340589 -1.145221826190881 SGVAITFLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGVAITFLTK 10 0 Q9BUQ8 Q9BUQ8 DDX23 Probable ATP-dependent RNA helicase DDX23 0 26033700.0 8873400.0 8302400.0 8857900.0 False True 11633113.330127846 7063714.282501731 7941369.478976617 1.0 0.607207553304572 0.6826521201688784 23.471733916211715 -10.818519158073032 7.247430007515629 1.0171808434364782 0.6449298367367252 0.9672488116304361 0.030800115447139714 0.008283735953696148 0.00020743043192550866 0.028892260319054095 0.00994069451566982 1.518730944634121e-11 10.818519158073032 -0.372251006699753 SGVAITFLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGVAITFLTK 10 0 Q9BUQ8 Q9BUQ8 DDX23 Probable ATP-dependent RNA helicase DDX23 0 21577800.0 7498400.0 4593100.0 9486300.0 False True 7260367.396416649 6427148.782700071 7001553.447100171 1.0 0.8852374035330757 0.9643524996484041 22.791611124098544 -10.152793840074207 4.8283765886078935 1.00000610402751 0.9247949515903807 0.5464435706636918 0.03229860274020498 2.1224422046174307e-06 3.7240976606530066e-07 0.03127552553941027 0.01042432920970581 7.034061480847707e-11 10.152793840074207 -0.07521115243712917 SGVAITFLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGVAITFLTK 10 0 Q9BUQ8 Q9BUQ8 DDX23 Probable ATP-dependent RNA helicase DDX23 0 43917000.0 11943000.0 11607000.0 20367000.0 False True 18118404.150253832 9535640.164095076 16341453.522826798 1.0 0.5262958086715096 0.901925654561462 24.11095255414839 -9.886279925434627 6.571784699952434 1.0000000137110054 0.7141107316164733 0.43577741858184893 0.15335024243182427 3.07723070680075e-08 5.218415255726117e-09 0.14848074151267807 0.049493577922936856 1.299331820976662e-10 9.886279925434627 -0.2858892820945321 SGVAITFLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGVAITFLTK 10 0 Q9BUQ8 Q9BUQ8 DDX23 Probable ATP-dependent RNA helicase DDX23 0 25413300.0 8873400.0 6217900.0 10322000.0 False True 12154135.774618544 5943172.618154358 7884156.188262938 1.0 0.4889835631559648 0.648680937457306 23.534943977734606 -10.929185316334763 11.573695685629541 1.0653218792354586 0.5688322503066354 0.9067104689757811 0.06519618005009022 0.03142534061212083 0.00019227840715421314 0.018052314086373884 0.021041976630861638 1.1771035884376253e-11 10.929185316334763 -0.4964896289288232 SGVAITFLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGVAITFLTK 10 0 Q9BUQ8 Q9BUQ8 DDX23 Probable ATP-dependent RNA helicase DDX23 0 15751400.0 7498400.0 3116200.0 5136800.0 False True 6235251.835443545 3099412.412082728 6210881.130120313 1.0 0.49707894626877586 0.9960914641515038 22.57201639953282 -10.906687536674548 11.02603615064563 1.02371184635328 0.7465852052159752 0.25587404779607836 0.20372100734569157 0.0953517904915898 0.0008069531332482482 0.15838995504290346 0.06575067239353846 1.2396881884200157e-11 10.906687536674548 -0.2771266411373048 SGVAITFLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGVAITFLTK 10 0 Q9BUQ8 Q9BUQ8 DDX23 Probable ATP-dependent RNA helicase DDX23 0 47740000.0 11943000.0 22389000.0 13408000.0 False True 15460448.93172559 21143032.468487255 10967881.57769778 1.0 1.3675561791159072 0.7094154656266906 23.88207887624084 -6.7550984690391545 1.630575528523329 1.2147841494241522 0.707546177978121 0.6708225686383618 0.1545062165874729 0.29120829773422985 1.5247135343160796 0.07480089578399467 0.18066372887568777 1.7575250792455452e-07 6.7550984690391545 -0.5072379714460312 SGVAYIAAPSGSAADK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGVAYIAAPSGSAADK 16 0 P31939-2;P31939 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 7983600.0 0.0 3753400.0 4230200.0 False True 0.0 3193407.3506386117 3792499.482943688 0.0 SGVAYIAAPSGSAADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGVAYIAAPSGSAADK 16 0 P31939-2;P31939 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 7039660.0 1960700.0 932060.0 4146900.0 False True 1898458.6517329176 1304236.4186286896 3060702.4856666606 1.0 0.6869975374170934 1.612203922836478 20.85639714684874 -6.815434904022926 1.3915110776226998 0.8304773784056573 1.6304915542799678 0.8735629134810392 0.13662842502743905 0.199478140232287 0.7601541723256033 0.07718137881304475 0.17814303102232207 1.529554992746322e-07 6.815434904022926 0.8000141758743106 SGVAYIAAPSGSAADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGVAYIAAPSGSAADK 16 0 P31939-2;P31939 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 7518300.0 0.0 3247800.0 4270500.0 False True 0.0 3104301.4569616276 3261895.8537082784 0.0 SGVDPSVTDK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGVDPSVTDKR 11 1 E9PR10;E9PKE2;E9PP91;E9PIL2;Q8N9B4-2;Q8N9B4 E9PR10 ANKRD42 Ankyrin repeat domain-containing protein 42 1 5811120.0 156900.0 700350.0 4953870.0 True False 238028.77092646933 575367.0706404751 3974735.4231416434 1.0 2.4172164919433823 16.698550379733295 17.860776439416618 -6.9260705094473165 0.7783665637604207 0.7482982306503124 19.35716914967686 0.995708061885991 0.4644846018478704 0.09473009265722586 0.08805534210016792 0.41366428747094247 1.3212317948541255 1.1855762494919734e-07 6.9260705094473165 18.608870919026547 SGVGNIFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGVGNIFIK 9 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;Q4VXU2;E5RH24;Q4VXU2-2;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC1L;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 5 0 26053400.0 6577300.0 8596100.0 10880000.0 False True 8622903.994663795 7313595.387335367 9754241.96832947 1.0 0.8481592038901647 1.1312015040832872 23.03974238679915 -6.760990534788334 1.6086759733406257 0.9119088162530004 1.1322879309571063 0.6949772277642379 0.0638743340190457 0.281280918524575 1.4348482479761704 0.03132450142620401 0.07520623026971933 1.733841785479618e-07 6.760990534788334 0.22037911470410598 SGVGNIFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGVGNIFIK 9 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;Q4VXU2;E5RH24;Q4VXU2-2;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC1L;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 5 0 24573700.0 10954000.0 2637700.0 10982000.0 False True 10606271.265916456 3690947.365423789 8105484.747061978 1.0 0.3479966967547539 0.764216239981451 23.33841421663253 -10.662189138534583 6.10227888087865 1.0038535653734046 0.5561064683683313 0.6026276627694231 0.16992091697994904 0.00895950183904173 0.0004959809493767762 0.16546757996938397 0.054841740136303 2.1767615697512044e-11 10.662189138534583 -0.4477470970050733 SGVGNIFIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGVGNIFIK 9 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;Q4VXU2;E5RH24;Q4VXU2-2;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC1L;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 5 0 43699100.0 7390000.0 29589000.0 6720100.0 False True 11211170.281367803 24308611.770087823 5391869.289475541 1.0 2.168249269256669 0.4809372397488653 23.418433546369396 -6.720426361140525 1.7575543422318807 1.710399348632007 0.48345195503183347 0.514685845356809 0.49157526669569146 0.35446020313666976 2.1400284210622114 0.22205017439763555 0.5571974052868222 1.9035909826055467e-07 6.720426361140525 -1.2269473936001736 SGVGNIFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGVGNIFIK 9 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;Q4VXU2;E5RH24;Q4VXU2-2;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC1L;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 5 0 26702500.0 6577300.0 10674000.0 9451200.0 False True 9009105.554849142 10202387.38580223 7219021.213573992 1.0 1.1324528637929883 0.8013027674748867 23.102952448322043 -6.798139653256246 1.4633650577117074 1.0732523618538017 0.7969314506552495 0.8267195264608135 0.05665020351100178 0.2234142955325776 0.9446955567397753 0.030456919669464684 0.07091747703059748 1.5916968131414093e-07 6.798139653256246 -0.2763209111985522 SGVGNIFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGVGNIFIK 9 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;Q4VXU2;E5RH24;Q4VXU2-2;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC1L;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 1-like;Polyadenylate-binding protein 5 0 16461900.0 10954000.0 3120100.0 2387800.0 False True 9108736.344479967 3103291.402008638 2887077.940060211 1.0 0.3406939540948816 0.3169570213556378 23.118819492066805 SGVGNIFIK(ub)NLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGVGNIFIKNLDK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;E5RH24;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 5 1 17522200.0 5422200.0 6820100.0 5279900.0 True False 5250075.228962217 9543401.496351661 3896935.796395242 1.0 1.8177647138664155 0.7422628489012242 22.32390666480258 -6.70343949075658 1.8188807283832822 1.5060770500573828 0.7452700624678157 0.4338566570453667 0.3449751425711362 0.38837274093736385 2.5003363133141776 0.15118480874332355 0.3871252695652375 1.9795228043485966e-07 6.70343949075658 -0.7608069875895671 SGVGNIFIK(ub)NLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGVGNIFIKNLDK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;E5RH24;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 5 1 13776700.0 4827100.0 5231000.0 3718600.0 True False 6611809.317472579 4999877.123396234 2840343.2669709874 1.0 0.7562040711282157 0.4295863856002328 22.656613687677403 -6.967067061454458 0.32060009989325977 1.0444163991319821 0.13082986346523257 0.9999496327780134 0.0016584647481958058 0.07726635749562906 0.012422645808452806 0.004938902554096091 0.028714830402592807 1.0787801298521163e-07 6.967067061454458 -0.9135865356667496 down SGVGNIFIK(ub)NLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGVGNIFIKNLDK 13 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;E5RH24;Q96DU9-2;Q96DU9 P11940 PABPC1;PABPC5 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 5 1 23180000.0 12485000.0 6055500.0 4639500.0 True False 16162078.616142826 5718506.101787689 3795158.605290041 1.0 0.3538224406405247 0.23481871951169717 23.946109420243907 -13.999999999999998 0.23794200918582542 5.234825176210851 0.18116359694210282 0.9995216085727732 0.0073531860661325945 13.551649181032843 0.15439816431027892 27.2359912233335 0.058861248361021516 1.0000000000000041e-14 13.999999999999998 -5.0536615792687485 SGVGNVFIK(ub)NLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGVGNVFIKNLDK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 8787300.0 2850900.0 3133800.0 2802600.0 True False 3737557.5081548737 2666249.2554567247 2512613.836437513 1.0 0.7133667507829135 0.672260916642837 21.833664346920283 -13.999999999999998 0.2735428790311408 3.2550322435328876 0.6590781257909369 0.9995909933502038 0.0029481973641307356 15.059858399923737 0.16559976442543922 18.925626655972167 0.016775284555224985 1.0000000000000041e-14 13.999999999999998 -2.5959541177419507 SGVGNVFIK(ub)NLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGVGNVFIKNLDK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 9159200.0 2640300.0 3564800.0 2954100.0 True False 2556485.1217271523 4988243.230186418 2180332.588899634 1.0 1.951211523897459 0.8528633984095354 21.285730199153875 -6.677639689943395 1.910040440499713 1.6031011309147303 0.857092787456301 0.3134692104566831 0.40335363395798873 0.44378069478499294 3.128076055291097 0.1695684461962658 0.44862056056074084 2.100681980251217e-07 6.677639689943395 -0.7460083434584293 SGVGNVFIK(ub)NLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGVGNVFIKNLDK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 8788500.0 2850900.0 3157400.0 2780200.0 True False 3904954.7726756353 3017895.627874452 2123574.0200163377 1.0 0.7728375368113728 0.543815266408652 21.896874408443175 -6.971023986706314 0.2324321907018503 1.0903541967958474 0.2197355462369177 0.9999893037862149 0.0006090624865985174 0.07597180479720343 0.007831145297221074 0.005780591168305154 0.022640414329491182 1.0689958354209289e-07 6.971023986706314 -0.8706186505589297 SGVGNVFIK(ub)NLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGVGNVFIKNLDK 13 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0YEQ8;B1ANR1 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 18607100.0 4078100.0 4462000.0 10067000.0 True False 5279180.841369004 4213685.777586769 8234909.296142864 1.0 0.7981703798754639 1.5598839182799005 22.331882656525664 -6.836232011416183 1.2996560607556344 0.8925215524212415 1.5831437870073717 0.9177982891766764 0.09238225134616197 0.1732473143055506 0.5700429003985199 0.055767852471988955 0.12838621951714077 1.458035131860911e-07 6.836232011416183 0.6906222345861301 SGVGTALLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGVGTALLLK 10 0 P02786;G3V0E5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 0 7727500.0 2317100.0 2244000.0 3166400.0 False True 3037740.5388283213 1909203.9470434887 2838771.3022535346 1.0 0.6284947389811911 0.9345009114400763 21.534567220161147 -9.98226012612563 6.6967507130723885 1.0000000334122359 0.7814978252106324 0.4046958773563043 0.12492649677773468 6.229463634144118e-08 9.689442945467813e-09 0.12095957840439668 0.04031985346001606 1.041693307230728e-10 9.98226012612563 -0.2185022082016035 SGVGTALLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGVGTALLLK 10 0 P02786;G3V0E5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 0 3770500.0 2317100.0 1453400.0 0.0 False True 3173794.487273043 1389183.9822489189 0.0 1.0 0.4377044537129183 0.0 21.59777728168404 -8.137190140548743 0.5568972360543476 1.0224392751949087 1.718567613265116e-16 0.990703482034783 0.03946437394456385 0.1196764892935632 0.17051797103069138 0.0507767919103517 0.0741357270035271 7.2913821286729495e-09 8.137190140548743 -1.0224392751949085 SGVK(ub)IHVSDQELQSANASVDDSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGVKIHVSDQELQSANASVDDSR 23 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 17733400.0 7419300.0 5974000.0 4340100.0 True False 7183778.382619503 8359449.353998447 3203297.609790898 1.0 1.1636563530722737 0.445907075521843 22.776311413386043 -6.846763221504833 1.2506827093511348 1.0871454875295725 0.41896804503570645 0.9354507385246471 0.07803144210775925 0.16105441654664265 0.4864283757205935 0.04886021678953406 0.11285130195943305 1.4231044559521257e-07 6.846763221504833 -0.668177442493866 down SGVK(ub)IHVSDQELQSANASVDDSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGVKIHVSDQELQSANASVDDSR 23 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 16786700.0 7419300.0 8063000.0 1304400.0 True False 6169476.680719397 8019563.018619808 1577144.009135832 1.0 1.299877353241682 0.2556365946020446 22.55671668882032 -6.829922035475326 1.3282668406102816 1.1602421172558788 0.2275826509548154 0.9057193673945538 0.13479379112963477 0.18090562326192108 0.6242439855910752 0.0796798799845384 0.18336568502661796 1.4793739414708392e-07 6.829922035475326 -0.9326594663010634 down SGVNSELVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGVNSELVK 9 0 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2 H0Y993 DEK Protein DEK 0 13451800.0 2306600.0 5006900.0 6138300.0 False True 3159412.353521209 4785678.60239584 4688559.962256767 1.0 1.5147369405776154 1.483997477262283 21.591224813327756 -10.131140931244724 4.847874815962235 0.9999693599074413 1.4993672089226993 0.9971661204294104 0.01254933335776422 4.15623685814489e-06 7.448982775258952e-07 0.012151583963923497 0.004050279923699334 7.393653075109073e-11 10.131140931244724 0.49939784901525797 SGVPVLAVSLALEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGVPVLAVSLALEGK 15 0 Q53EL6;Q53EL6-2;Q5VZS7 Q53EL6 PDCD4 Programmed cell death protein 4 0 6397400.0 2787600.0 1614500.0 1995300.0 False True 2699109.1638550954 2259178.269506274 1472671.0722830757 1.0 0.8370088545361111 0.5456137499009794 21.364051896246593 -6.9621775982284095 0.4035726012591813 1.0154006159385867 0.3565203453755017 0.9998426305143758 0.002357833212622723 0.07893221307053691 0.018323097479567778 0.0037486707820367144 0.024382412505364017 1.0909940995056281e-07 6.9621775982284095 -0.658880270563085 SGVPVLAVSLALEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGVPVLAVSLALEGK 15 0 Q53EL6;Q53EL6-2;Q5VZS7 Q53EL6 PDCD4 Programmed cell death protein 4 0 60631000.0 13304000.0 24143000.0 23184000.0 False True 20183140.652681638 19834493.019880045 18601672.2380918 1.0 0.9827257987841813 0.9216440869236218 24.266647350623153 -6.947709830706438 0.5834513603851924 1.0007210884200215 0.9006096674079146 0.9990090050467971 0.0010581509258979658 0.08441872690367544 0.039871311332835224 0.0011045688498545103 0.005107383687820316 1.127950832961147e-07 6.947709830706438 -0.1001114210121069 SGVPVLAVSLALEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGVPVLAVSLALEGK 15 0 Q53EL6;Q53EL6-2;Q5VZS7 Q53EL6 PDCD4 Programmed cell death protein 4 0 1156130.0 440210.0 340320.0 375600.0 False True 602967.5332279421 325283.5371122554 286891.0157248169 1.0 0.5394710646705537 0.47579844670734933 19.201720796774346 -13.999999999999998 0.27877499497102187 4.728057556593158 0.4563976834264848 0.9996024696637769 0.004656639471594155 15.332443178143341 0.1672398734961616 32.56517263782566 0.025334668288702213 1.0000000000000041e-14 13.999999999999998 -4.271659873166673 SGVPVLAVSLALEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGVPVLAVSLALEGK 15 0 Q53EL6;Q53EL6-2;Q5VZS7 Q53EL6 PDCD4 Programmed cell death protein 4 0 5642600.0 2787600.0 1369000.0 1486000.0 False True 2318012.9116188018 1361624.9252747765 1796715.7295123008 1.0 0.5874104145191649 0.7751103199237794 21.14445717168087 -10.218644823516282 5.855566028001126 1.0000084753795464 0.6812603672214684 0.793596528720248 0.07662816550167598 8.47870392684439e-06 1.1314104523385244e-06 0.07419687363499573 0.02473163406986612 6.044427551330582e-11 10.218644823516282 -0.31874810815807797 SGVPVLAVSLALEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGVPVLAVSLALEGK 15 0 Q53EL6;Q53EL6-2;Q5VZS7 Q53EL6 PDCD4 Programmed cell death protein 4 0 40142000.0 13304000.0 13271000.0 13567000.0 False True 17222290.261046395 12532457.183853421 11097945.20917555 1.0 0.727688187453181 0.6443942728265956 24.037773672715602 -13.999999999999998 0.1659272084709917 2.3592542756827966 0.5676406955534526 0.9995220450859328 0.0033199368184354734 12.05448833258536 0.1289016185829668 5.272513918273088 0.07051180673684689 1.0000000000000041e-14 13.999999999999998 -1.791613580129344 SGVSITIDDPVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGVSITIDDPVR 12 0 S4R3H4;E7EQT4;Q9UKV3-5;Q9UKV3;G3V3B0;Q9UKV3-3;Q9UKV3-2 S4R3H4 ACIN1 Apoptotic chromatin condensation inducer in the nucleus 0 11943900.0 5207900.0 3563300.0 3172700.0 False True 4330599.59908866 3544103.7956403242 3836096.901092649 1.0 0.8183863953587748 0.8858119559009622 22.046135358420266 -10.770419765265038 9.586287679430237 1.000931426127544 0.8520991761471561 0.8651473980702424 0.027526369824915707 0.0005511802701996548 1.320008540499011e-05 0.026808859218078535 0.008884097659453737 1.696603016142325e-11 10.770419765265038 -0.1488322499803878 SGVSLAALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGVSLAALK 9 0 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 0 40877000.0 6897000.0 13902000.0 20078000.0 False True 9042033.790643018 11827875.78957158 18000521.161775634 1.0 1.3080990475628878 1.9907602181716177 23.108215878432297 -6.957993583685884 0.46284997854337734 0.9806579579434972 2.3458523530398416 0.9996883755116621 0.0073082774171648575 0.08042586897145011 0.02384015957393296 0.009317044360930763 0.05637794016893255 1.1015555839237214e-07 6.957993583685884 1.3651943950963443 SGVSLAALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGVSLAALK 9 0 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 0 29421500.0 11220000.0 7967500.0 10234000.0 False True 10863827.241517503 11148964.299963601 7553408.386580978 1.0 1.0262464647225253 0.6952806058729158 23.373029107100148 -6.887714706384017 1.0357849538096837 1.0187695571961195 0.6680548286171937 0.9793956185626688 0.021562214689844126 0.121017827868688 0.23282453487463697 0.01590699478874768 0.03934456454701683 1.2950462946054687e-07 6.887714706384017 -0.3507147285789258 SGVSLAALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGVSLAALK 9 0 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 0 33998900.0 6897000.0 7934900.0 19167000.0 False True 9447007.284416806 7584309.880794651 14640149.356756015 1.0 0.8028267209347086 1.5497129319361795 23.17142593995519 -6.836509391324329 1.2983866113616247 0.8950119725448102 1.5726467471774639 0.9183025253905944 0.09033143321628409 0.1729168809606406 0.5677328603713901 0.05458102974429629 0.12565919293210107 1.4571041954973834e-07 6.836509391324329 0.6776347746326536 SGVSLAALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGVSLAALK 9 0 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 0 21606800.0 11220000.0 7183200.0 3203600.0 False True 9329927.130278008 7144502.67584644 3873457.9482271937 1.0 0.7657618946090903 0.41516486614957887 23.153434382534424 -6.965293222423423 0.352984292966559 1.0327385594879326 0.13630338831780572 0.9999190617382651 0.002162119774731914 0.07786160355413996 0.014509924683241167 0.004777205911934912 0.030076083660786613 1.0831953265413132e-07 6.965293222423423 -0.8964351711701268 down SGVSLAALKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGVSLAALKK 10 1 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 0 19642100.0 7930900.0 4967700.0 6743500.0 False True 10397486.702944843 4226538.523942936 6045747.308219643 1.0 0.40649617015099127 0.5814623746051368 23.309731504174618 -10.908285058662546 11.436664422354713 1.0452121646155377 0.4939792723780641 0.9177114961181441 0.07142965385735567 0.037116777684701244 0.00029765297668349187 0.03117447325203163 0.02305382165124156 1.2351364585491876e-11 10.908285058662546 -0.5512328922374736 SGVSLAALKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGVSLAALKK 10 1 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 0 3757420.0 2039900.0 1037600.0 679920.0 False True 1975144.491084805 1451919.0910125172 501828.554837222 1.0 0.7350951272507068 0.25407181960728537 20.913526766384308 -7.064829494665774 0.43405346452623916 1.0193425002972176 2.3932511290546257e-11 0.9997732953339826 0.0046488324880470475 0.07400118086131309 0.021439090975563783 0.006648322852087146 0.0373846824461868 8.613318473141197e-08 7.064829494665774 -1.0193425002732852 down SGVSLAALKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGVSLAALKK 10 1 P10412;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.3;Histone H1.2 0 14206200.0 7930900.0 3915900.0 2359400.0 False True 10863168.054513717 3742882.5898503754 1802158.313368297 1.0 0.3445479781835082 0.16589620121171636 23.37294156569751 -13.999999999999224 0.18241282005275375 4.426471756976646 0.027463597120984208 0.9994954264309766 0.008054839821163558 12.236893307543122 0.13541218168812272 14.869642931884007 0.1307020360552192 1.0000000000017874e-14 13.999999999999224 -4.399008159855662 SGVTAEK(ub)APPPPPPPTLYVQLHGETTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGVTAEKAPPPPPPPTLYVQLHGETTR 27 1 O60346 O60346 PHLPP1 PH domain leucine-rich repeat-containing protein phosphatase 1 1 17776000.0 3449800.0 7063100.0 7263100.0 True False 4465834.105724437 6670032.276036105 5941290.325699332 1.0 1.49356920076504 1.3303876017435605 22.090498229061822 -9.957531174010576 4.677433472966052 0.9999950127403628 1.411978401054609 0.8947208652735641 0.06661860895366332 10716897.790022723 11407308.353180423 482.49112694397564 0.022805321466878054 1.1027290762200338e-10 9.957531174010576 0.4119833883142462 SGVWLVAPLIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGVWLVAPLIAK 12 0 Q93074-3;Q93074;Q93074-2;Q7Z3Z5 Q93074-3 MED12;TNRC11 Mediator of RNA polymerase II transcription subunit 12 0 1492700.0 344090.0 594050.0 554560.0 False True 451105.3221723003 505420.05558876356 497179.4509151459 1.0 1.1204036635056982 1.1021360788229573 18.78310478161199 -10.085829599895963 4.458394209440073 0.9999908133082385 1.1112698711693532 0.9801857785861304 0.007457710241000441 6.929014707850332e-07 1.4207772399769863e-07 0.007221503297882022 0.0024069656270714578 8.206734812218887e-11 10.085829599895963 0.1112790578611147 SGVWLVAPLIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGVWLVAPLIAK 12 0 Q93074-3;Q93074;Q93074-2;Q7Z3Z5 Q93074-3 MED12;TNRC11 Mediator of RNA polymerase II transcription subunit 12 0 1267730.0 344090.0 396090.0 527550.0 False True 471309.37168261246 378589.4341055272 402953.555233299 1.0 0.8032716021621475 0.8549661420792934 18.84631484313488 -10.853165781414406 6.880428157401404 1.016688288857529 0.8291188721211914 0.9357708806052272 0.02110420754749074 0.005544982733847833 0.00011833454514066511 0.02097281754271058 0.006811353697194706 1.4022783165515995e-11 10.853165781414406 -0.18756941673633765 SGVYQHVTGEMMGGHAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGVYQHVTGEMMGGHAIR 18 0 P07858;R4GMQ5 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 23074500.0 4194900.0 6892600.0 11987000.0 False True 5499554.523469389 5864250.947144374 10746700.227423271 1.0 1.0663138118039635 1.9541037699620303 22.390883331086854 -6.921875689556194 0.8106925843767775 0.981704366484711 2.1036329982455295 0.9946863403662305 0.0317079343215515 0.09708057918974244 0.09998679177970281 0.02759458849394159 0.08420125921852213 1.1970831298113396e-07 6.921875689556194 1.1219286317608184 SGVYQHVTGEMMGGHAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGVYQHVTGEMMGGHAIR 18 0 P07858;R4GMQ5 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 18593500.0 6261700.0 2082800.0 10249000.0 False True 6062925.76098129 2914472.90165851 7564479.436590627 1.0 0.48070403903260067 1.2476615638728041 22.531582726429008 -6.724337239715154 1.7436670858018921 0.6855417022897138 1.2467725114515908 0.5329351268316362 0.21841329103952312 0.3469501996102352 2.0637505990739764 0.09937069054340243 0.24819802363916163 1.8865258491948747e-07 6.724337239715154 0.5612308091618771 SGVYQHVTGEMMGGHAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGVYQHVTGEMMGGHAIR 18 0 P07858;R4GMQ5 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 35572600.0 5687900.0 24486000.0 5398700.0 False True 8628960.141189706 20116281.990008816 4331644.578665735 1.0 2.3312521625850633 0.5019891745691291 23.04075528289547 -6.711534415577093 1.7895539213860703 1.8171271137093665 0.5060546397922551 0.47247046563115 0.5608486590833749 0.3719996208367202 2.3231913294518436 0.24930375019207726 0.6322159709919842 1.9429677156497068e-07 6.711534415577093 -1.3110724739171116 SGVYQHVTGEMMGGHAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGVYQHVTGEMMGGHAIR 18 0 P07858;R4GMQ5 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 16481200.0 4194900.0 5120100.0 7166200.0 False True 5745867.892909967 4893877.052093498 5473691.152521778 1.0 0.8517211226057301 0.9526308739670054 22.454093392609746 -10.208820955996055 4.265800492600959 1.0000412508991503 0.9021759982818708 0.5561543125156274 0.041196233499480615 57970210.81979566 1.6154642701342437 23488.51611463111 0.014102566480221448 6.1827123861203e-11 10.208820955996055 -0.09786525261727952 SGVYQHVTGEMMGGHAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SGVYQHVTGEMMGGHAIR 18 0 P07858;R4GMQ5 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 12840000.0 6261700.0 4273300.0 2305000.0 False True 5206880.990344183 4250278.884716357 2786964.8428841527 1.0 0.8162811657493649 0.5352465032429962 22.311988001863284 -6.964929370578938 0.3592631952143195 1.0244215030044517 0.31748646388145874 0.9999116803547292 0.0017960735028181795 0.07798494816260877 0.014944559228487532 0.003776187023831274 0.024014524913330493 1.0841032076634013e-07 6.964929370578938 -0.7069350391229929 SGVYQHVTGEMMGGHAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGVYQHVTGEMMGGHAIR 18 0 P07858;R4GMQ5 P07858 CTSB Cathepsin B;Cathepsin B light chain;Cathepsin B heavy chain 0 15220300.0 5687900.0 5703300.0 3829100.0 False True 7363098.675271027 5385906.341396375 3132243.089883844 1.0 0.731472791405736 0.4253974078065102 22.81188160498792 -6.969418731386565 0.27170925942767415 1.0745287592268862 0.07311878874289526 0.9999774873586181 0.0011138025591238474 0.07649176152004483 0.009703058786213954 0.005937623415225328 0.028400319219628843 1.072954408753931e-07 6.969418731386565 -1.001409970483991 down SGWALNMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGWALNMK 8 0 P41240 P41240 CSK Tyrosine-protein kinase CSK 0 9078400.0 3161300.0 2263900.0 3653200.0 False True 4144494.9140727464 1926134.944613084 3275201.9079688634 1.0 0.46474539951125043 0.7902535715143058 21.98276486179001 -10.431547227157576 5.923242898674087 1.0001599716509815 0.6274994855127847 0.6358469802059272 0.132888154752265 0.0002808505361026577 2.695291789284258e-05 0.12872304377242974 0.042889467521979606 3.7021394446266443e-11 10.431547227157576 -0.3726604861381968 SGWALNMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGWALNMK 8 0 P41240 P41240 CSK Tyrosine-protein kinase CSK 0 7364300.0 3161300.0 1863400.0 2339600.0 False True 4330118.040920227 1781068.826560228 1787034.6655744973 1.0 0.4113210794091237 0.4126988337700653 22.0459749233129 -10.08646474038024 5.2278715462242165 1.0000098407019584 0.41200995658886835 0.9999958817862912 0.0005624658655399062 6.458888711374171e-08 1.1285634126165286e-08 0.0005446143449308429 0.00018153507707057743 8.194741521722483e-11 10.08646474038024 -0.58799988411309 SGWALNMK(ub)ELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGWALNMKELK 11 1 P41240 P41240 CSK Tyrosine-protein kinase CSK 1 5075500.0 1397400.0 1556200.0 2121900.0 True False 1353040.3018980864 2177598.775475789 1566110.7343644889 1.0 1.60941161354986 1.1574753037049235 20.36777338164865 -10.397067394397437 8.351334908415678 0.999996464981908 1.3834434586273916 0.4897474113360287 0.184502225892742 1.2144140728285117e-05 8.765812221957912e-07 0.1786451590167718 0.05954783735173236 4.008045154213838e-11 10.397067394397437 0.3834469936454836 SGYAFVDYPDQNWAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGYAFVDYPDQNWAIR 16 0 F8W930;Q9Y6M1-1;Q9Y6M1 F8W930 IGF2BP2 Insulin-like growth factor 2 mRNA-binding protein 2 0 3227780.0 0.0 999880.0 2227900.0 False True 0.0 1399137.2983053185 1644346.1544326502 0.0 SGYLLPDTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SGYLLPDTK 9 0 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 0 54925400.0 6324400.0 23461000.0 25140000.0 False True 8291349.645576718 19960710.25026174 22538753.95990836 1.0 2.4074138835660377 2.718345616015888 22.9831755285238 -10.257611335599506 0.3376782183302697 1.3509342836606887e-13 2.788387554986576 0.9989881074262211 0.023781472272262703 1.6906426874617229 0.15679036577751623 1.6384515910936197 0.09607206231337954 5.525717326662435e-11 10.257611335599506 2.788387554986441 SGYLLPDTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SGYLLPDTK 9 0 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 0 50703900.0 16957000.0 5898900.0 27848000.0 False True 16418709.316792527 8254361.532357123 20553773.37790766 1.0 0.5027411943955197 1.25185073816283 23.968837384783424 -6.727694211810319 1.7312293109320778 0.6999990694829757 1.2512564351325826 0.5487642714755485 0.20907587207737596 0.3405578615908353 1.9984933074371476 0.09573749307684469 0.2382257858848413 1.871999757699854e-07 6.727694211810319 0.5512573656496068 SGYLLPDTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SGYLLPDTK 9 0 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 0 110603000.0 10341000.0 90140000.0 10122000.0 False True 15688053.028365964 74053812.73296548 8121382.263369792 1.0 4.720395360665018 0.5176794245076375 23.90316298142431 -6.673065497929375 1.926442450491494 3.3684013158415977 0.5343836725605281 0.2927544134450445 1.5792300836692752 0.4540961322380598 3.2518099564736924 0.6592653253630042 1.7544218395529725 2.1229242699752406e-07 6.673065497929375 -2.8340176432810695 SGYLLPDTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SGYLLPDTK 9 0 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 0 55587400.0 6324400.0 26407000.0 22856000.0 False True 8662701.590483626 25240251.423728608 17457883.534095895 1.0 2.913669732252601 2.0152931913612466 23.046385590046693 -9.66683559976641 6.152331959856083 0.9999999908585883 2.464481461816239 0.7798884624092839 0.3667606870449757 4.5981537696898285e-08 1.0321195826924342e-08 0.3551145108733584 0.11837150274251852 2.1535968148837235e-10 9.66683559976641 1.4644814709576508 SGYLLPDTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SGYLLPDTK 9 0 P14625;H0YIV0 P14625 HSP90B1 Endoplasmin 0 31288100.0 10341000.0 9359100.0 11588000.0 False True 13386628.35158454 8838257.857689904 9479102.902920773 1.0 0.6602303153238539 0.7081023431713301 23.67428930351676 -10.106744960537702 4.997407213942865 1.0000100248645212 0.6841663292492796 0.9830609695562299 0.019543673539421543 27226341.668027084 1.2838013488193074 3399.7757755241373 0.006690319282274942 7.820869503701082e-11 10.106744960537702 -0.3158436956152416 SHAIFQIFVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SHAIFQIFVK 10 0 A0A494BYR6;Q86Y91-6;Q86Y91 A0A494BYR6 KIF18B Kinesin-like protein KIF18B 0 9624500.0 2221800.0 2864700.0 4538000.0 False True 2876163.898225563 2705276.9267263166 3712130.563812089 1.0 0.9405851065703611 1.2906533477116071 21.455714459433757 -6.863207449168774 1.169330330571913 0.9674427668536889 1.3086813959567862 0.957426521238425 0.031559740953250585 0.1435394074516894 0.37112467384361264 0.02102040053178425 0.04926205998928903 1.370227094314866e-07 6.863207449168774 0.3412386291030973 SHAIFTIHVCQTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHAIFTIHVCQTR 13 0 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-3;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4;H0YIM7 A0A1B0GV47 KIF21A Kinesin-like protein KIF21A;Kinesin-like protein 0 10444200.0 3607700.0 2668800.0 4167700.0 False True 4729729.637016501 2270625.4429009235 3736466.3834013515 1.0 0.48007510305244994 0.7899957651191037 22.17332628724752 -10.301123503566991 5.939327982508392 1.0000257865932363 0.6350354340857799 0.6490007844673418 0.12652458046814322 4.320544998022337e-05 5.084098066752676e-06 0.12251553973210093 0.04083563275324945 4.998923566369829e-11 10.301123503566991 -0.3649903525074564 SHAIFTIHVCQTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SHAIFTIHVCQTR 13 0 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-3;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4;H0YIM7 A0A1B0GV47 KIF21A Kinesin-like protein KIF21A;Kinesin-like protein 0 24181300.0 5456200.0 8730300.0 9994800.0 False True 8277454.301650756 7172309.754854766 8019323.399123545 1.0 0.866487387725524 0.9688151824075026 22.98075571010636 -10.154374864963675 5.004230580164667 1.0000048300614968 0.9176512851498003 0.4633769777932816 0.04177514724641162 2.251311679208725e-06 3.8046809852285454e-07 0.04045098444795911 0.01348287079747991 7.008500925645906e-11 10.154374864963675 -0.08235354491169644 SHAIFTIHVCQTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHAIFTIHVCQTR 13 0 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-3;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4;H0YIM7 A0A1B0GV47 KIF21A Kinesin-like protein KIF21A;Kinesin-like protein 0 8916600.0 3607700.0 2638300.0 2670600.0 False True 4941564.1844266355 2521731.1823086 2039859.2827334823 1.0 0.5103103163682157 0.41279627393328394 22.23653634877041 -13.999999999999998 0.2268727995926241 4.047197659508244 0.3639510071575571 0.9995056861107995 0.005712346297819491 13.195762729686189 0.15083763021360094 18.08169185688967 0.05162176442641111 1.0000000000000041e-14 13.999999999999998 -3.683246652350687 SHAIFTIHVCQTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SHAIFTIHVCQTR 13 0 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-3;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4;H0YIM7 A0A1B0GV47 KIF21A Kinesin-like protein KIF21A;Kinesin-like protein 0 19312100.0 5456200.0 8403900.0 5452000.0 False True 7063158.457781225 7936215.577378182 4459791.942244058 1.0 1.1236071829360053 0.6314160964817187 22.75188203219881 -6.840181513024984 1.2816280011013308 1.0657515089684486 0.6151762243956002 0.9247614687784786 0.057346608387060155 0.16857997271578548 0.5378234726208081 0.035086074119770466 0.08083201508032202 1.444835776599261e-07 6.840181513024984 -0.45057528457284846 SHAVACVNQFIISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHAVACVNQFIISR 14 0 Q92973-2;Q92973;Q92973-3 Q92973-2 TNPO1 Transportin-1 0 31963000.0 9187800.0 6850200.0 15925000.0 False True 12045294.774781773 5828176.86187046 14277233.763386633 1.0 0.48385506298047826 1.1852955058665466 23.52196636413181 -6.709534398576298 1.7969853910164337 0.6825353260554109 1.1836174649915034 0.46286395680858516 0.21751609888519777 0.3759972024454743 2.3665244657317 0.09633990545213965 0.24487584521097647 1.9519361235528944e-07 6.709534398576298 0.5010821389360925 SHAVACVNQFIISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHAVACVNQFIISR 14 0 Q92973-2;Q92973;Q92973-3 Q92973-2 TNPO1 Transportin-1 0 22043600.0 9187800.0 6785100.0 6070700.0 False True 12584777.950959068 6485311.846674791 4636925.689991067 1.0 0.5153298589730425 0.36845510568882894 23.5851764256547 -13.999999999999998 0.16726590661655313 3.4272071816059992 0.23505043960227062 0.9995191635160098 0.005917060929524371 12.06608812121993 0.12945291003612291 9.500674577523203 0.122792948379097 1.0000000000000041e-14 13.999999999999998 -3.1921567420037285 SHAVLLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHAVLLVK 8 0 H3BRB3;Q14807-2;Q14807;H3BTH5 H3BRB3 KIF22 Kinesin-like protein;Kinesin-like protein KIF22 0 4077840.0 1230100.0 796040.0 2051700.0 False True 1612673.0123053459 677273.9349396171 1839409.765296101 1.0 0.4199697829452987 1.140596854576633 20.62102251473159 -6.692447886408568 1.8575436518721076 0.6372008655809324 1.1381949925481356 0.38199650357679993 0.245190563090066 0.41142256754537676 2.754176844995832 0.10551782676189503 0.2739485583718087 2.03026212853464e-07 6.692447886408568 0.5009941269672032 SHAVLLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHAVLLVK 8 0 H3BRB3;Q14807-2;Q14807;H3BTH5 H3BRB3 KIF22 Kinesin-like protein;Kinesin-like protein KIF22 0 3175580.0 1230100.0 666180.0 1279300.0 False True 1684901.2122025674 636745.9648373353 977155.6880105379 1.0 0.3779129365127327 0.5799483559829377 20.68423257625448 -10.37829845305881 6.014977676799358 1.0000949230768945 0.4789306462478621 0.8986726352717556 0.08248061461186168 0.00010501241584191977 1.085391560086567e-05 0.07987592049401196 0.026620503898057545 4.1850586336697657e-11 10.37829845305881 -0.5211642768290324 SHEGETAYIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHEGETAYIR 10 0 J3KTL2;Q07955;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 23326900.0 2788600.0 12849000.0 7689300.0 False True 3655881.604840819 10931979.28500973 6893684.99697387 1.0 2.9902443423043295 1.8856422997522178 21.801787919021365 -10.47789071234416 6.011323401719254 0.9989548613561958 2.4379433210282717 0.6932036187322874 0.45095189551479165 0.006319752141494254 0.0005488970027945081 0.43685754988408887 0.14554409843912103 3.327432756506216e-11 10.47789071234416 1.438988459672076 SHEGETAYIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHEGETAYIR 10 0 J3KTL2;Q07955;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 15819000.0 4903600.0 2951000.0 7964400.0 False True 4747937.90209493 4129349.6892617005 5878284.713121506 1.0 0.8697143421862593 1.238071102515438 22.178869635532816 -6.81111535218993 1.409915508857428 0.9290880145337843 1.2446760233427987 0.8626923133392049 0.056513361807408 0.20529032540916345 0.8041066811431932 0.0315158337036429 0.07286385972233804 1.544844061739503e-07 6.81111535218993 0.3155880088090144 SHEGETAYIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SHEGETAYIR 10 0 J3KTL2;Q07955;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 59099900.0 3922500.0 50959000.0 4218400.0 False True 5950719.273161743 41864968.30551569 3384631.3910096 1.0 7.035278658553145 0.5687768546358051 22.504632629191345 -6.66166973105685 1.9667262001981425 4.879432339164802 0.5954984919694952 0.24283224824748972 2.5686524794844323 0.4804885028015741 3.574423639468499 1.0544829933252324 2.84845909043492 2.1793664902750943e-07 6.66166973105685 -4.283933847195306 SHEGETAYIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHEGETAYIR 10 0 J3KTL2;Q07955;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 17994400.0 2788600.0 8158000.0 7047800.0 False True 3819620.779081443 7797552.585101605 5383254.793997247 1.0 2.0414467917353805 1.4093689152282372 21.864997980544256 -10.154185532846503 4.841530511545166 0.9999497075432471 1.7254078534783948 0.6371752869472115 0.25804471257632233 0.00016235077477947543 2.8363185534076064e-05 0.24987068634133452 0.08328357285763593 7.011556970925084e-11 10.154185532846503 0.7254581459351477 SHEGETAYIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SHEGETAYIR 10 0 J3KTL2;Q07955;J3KSR8 J3KTL2 SRSF1 Serine/arginine-rich splicing factor 1 0 9589900.0 4903600.0 2941200.0 1745100.0 False True 4077560.6663129367 2925355.17181751 2109992.3415692565 1.0 0.7174277493859366 0.517464365153684 21.959274910967093 -7.730149586441013 0.12791112919678665 1.3815928444198486 1.4092303494109972e-15 0.9999852310044658 0.0007607253126181086 0.13449374496883326 0.015805997305693965 0.06694744712011844 0.09248545908073376 1.8614458781742305e-08 7.730149586441013 -1.3815928444198473 SHEGETSYIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHEGETSYIR 10 0 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 0 4916600.0 1580300.0 0.0 3336300.0 False True 1530134.2415124865 0.0 2462422.943145407 1.0 0.0 1.6092855622336666 20.545226798103933 -6.738650317308853 1.691678872654809 0.40407874061357923 1.6099487091783187 0.5988670242537658 0.4201718320954025 0.32025511668456874 1.799033746231454 0.19653401040121543 0.48298552470967476 1.8253648473743726e-07 6.738650317308853 1.2058699685647394 SHESYAK(ub)NYSVVFPHDEPLAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHESYAKNYSVVFPHDEPLAGR 22 1 Q9UL12;Q9UL12-2;A0A0A0MT55;Q5SYV1 Q9UL12 SARDH Sarcosine dehydrogenase, mitochondrial 1 30899400.0 5816400.0 13312000.0 11771000.0 True False 5631761.5657363925 18627551.021162923 8687821.977569338 1.0 3.3075887186866795 1.5426473362128825 22.425154824604185 -6.578276207137928 2.274368917376988 2.57305249766465 1.5469610200238286 0.0 1.0029271322954239 0.7044137464324156 6.851584224688173 0.3707416357596366 1.1211854506483625 2.640728744910564e-07 6.578276207137928 -1.0260914776408214 SHESYAK(ub)NYSVVFPHDEPLAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SHESYAKNYSVVFPHDEPLAGR 22 1 Q9UL12;Q9UL12-2;A0A0A0MT55;Q5SYV1 Q9UL12 SARDH Sarcosine dehydrogenase, mitochondrial 1 26908400.0 5816400.0 13949000.0 7143000.0 True False 4836594.3102093525 13873853.968340289 8636568.274499567 1.0 2.8685172000170835 1.78567142922635 22.20556010003846 -10.61453038810988 6.167246004362649 0.994433068680871 2.3270943146217165 0.6669629223893383 0.44206993476134104 0.03376774895305101 0.0021105722331136276 0.42714841062523407 0.1426774579324728 2.4292354595319518e-11 10.61453038810988 1.3326612459408453 SHFEQWGTLTDCVVMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHFEQWGTLTDCVVMR 16 0 P09651;F8W6I7;P09651-3;F8VZ49;Q32P51;F8W646;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 20217500.0 4776000.0 10644000.0 4797500.0 False True 6261382.250849795 9055956.689987035 4301100.720869546 1.0 1.4463190917241895 0.6869251147038341 22.578049748257765 -6.7474259757575625 1.659365146745101 1.2632487671531063 0.6857063587008335 0.6378309801417259 0.18752718179635258 0.30455252967334456 1.6490911838111832 0.08930526425149472 0.21739872470514346 1.7888504075191963e-07 6.7474259757575625 -0.5775424084522728 SHFEQWGTLTDCVVMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHFEQWGTLTDCVVMR 16 0 P09651;F8W6I7;P09651-3;F8VZ49;Q32P51;F8W646;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 35712100.0 13513000.0 7324100.0 14875000.0 False True 13084037.211642232 10248651.324676944 10978791.259565374 1.0 0.7832942660509747 0.8390981378283149 23.64130443184601 -10.848603238991641 6.923966229223078 1.016894473660308 0.8111962019396448 0.9385096127882534 0.02278183525436373 0.006037282917853586 0.00013200872988255712 0.022414330153968178 0.00735280571134931 1.4170878061574229e-11 10.848603238991641 -0.20569827172066324 SHFEQWGTLTDCVVMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 SHFEQWGTLTDCVVMR 16 0 P09651;F8W6I7;P09651-3;F8VZ49;Q32P51;F8W646;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 140091700.0 24434000.0 98973000.0 16684700.0 False True 37068164.36467401 81310494.8704215 13386961.731836211 1.0 2.1935398276131113 0.361144447298124 25.143677338107416 -6.730906044025525 1.719807512089536 1.7175257227496692 0.36202032911677845 0.5635510561393635 0.5016994759281912 0.3345221785418439 1.9387709113362364 0.23113131435042236 0.5729753272512076 1.8582064190079164e-07 6.730906044025525 -1.3555053936328907 SHFEQWGTLTDCVVMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHFEQWGTLTDCVVMR 16 0 P09651;F8W6I7;P09651-3;F8VZ49;Q32P51;F8W646;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 23802500.0 4776000.0 8454500.0 10572000.0 False True 6541816.266546997 8080952.23470723 8075111.33717456 1.0 1.2352765509528203 1.2343836953153822 22.641259809780657 -10.015270918365017 4.776368180735315 0.999995351377136 1.2348301231407015 0.999989155227931 0.00036450681031436575 251599.70334443892 0.018399827464328295 12.862989740740714 0.0001247803730646923 9.654484322166455e-11 10.015270918365017 0.2348347717635655 SHFEQWGTLTDCVVMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SHFEQWGTLTDCVVMR 16 0 P09651;F8W6I7;P09651-3;F8VZ49;Q32P51;F8W646;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 23445500.0 13513000.0 4414400.0 5518100.0 False True 11236658.227401655 4390618.751010203 6671909.1971883 1.0 0.3907406154174257 0.5937627595469814 23.421709707280286 -10.199534788105941 4.911592922776615 1.0000594413057784 0.49225168748127207 0.8929298415228416 0.08288344327046052 5.395501058854525e-05 8.79314141419318e-06 0.08026090676140424 0.026750516288103113 6.316335817852245e-11 10.199534788105941 -0.5078077538245063 SHFEQWGTLTDCVVMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SHFEQWGTLTDCVVMR 16 0 P09651;F8W6I7;P09651-3;F8VZ49;Q32P51;F8W646;P09651-2 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 80184700.0 24434000.0 38343000.0 17407700.0 False True 31630294.666146085 36209178.34379412 14239677.218085445 1.0 1.1447625994628756 0.4501911021817377 24.914803660199865 -6.85230880070247 1.223778529751223 1.0774377149831333 0.4211457601809859 0.9436066430917177 0.07105142998996586 0.15494260279773475 0.4453586305048822 0.045400302947391835 0.10523360208081911 1.4050481235960274e-07 6.85230880070247 -0.6562919548021475 down SHFIVALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHFIVALK 8 0 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;J3KT86;J3QR41;Q96GD4-3;J3KRJ2 Q96GD4-5 AURKB Aurora kinase B 0 31564700.0 7835300.0 7408400.0 16321000.0 False True 10272154.177153133 6303095.597717022 14632259.482086882 1.0 0.6136099097632399 1.4244587094137762 23.292235425692585 -6.777113780326904 1.5469879196429852 0.7803956709548923 1.4303238861266754 0.757080892684874 0.1632129366472957 0.2550887295241546 1.2055628290061573 0.08311218447688552 0.19659872886989 1.6706528644898863e-07 6.777113780326904 0.6499282151717831 SHFIVALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHFIVALK 8 0 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;J3KT86;J3QR41;Q96GD4-3;J3KRJ2 Q96GD4-5 AURKB Aurora kinase B 0 21320700.0 7195300.0 3979400.0 10146000.0 False True 6966889.140008086 5568395.1722968565 7488458.226524376 1.0 0.7992656493297371 1.074863985350524 22.732083176044632 -6.711388950868605 1.7900671403291544 0.8767686756162032 1.0742482455728741 0.4717482103784919 0.08457031530458288 0.37230817390717225 2.3263621764940563 0.037582834273693674 0.09532424484824736 1.9436186117183864e-07 6.711388950868605 0.19747956995667093 SHFIVALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SHFIVALK 8 0 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;J3KT86;J3QR41;Q96GD4-3;J3KRJ2 Q96GD4-5 AURKB Aurora kinase B 0 22675700.0 6151000.0 7243100.0 9281600.0 False True 9331516.698334692 5950512.214401404 7447087.691730198 1.0 0.637678997612825 0.7980575861863067 23.153680157939494 -10.15263157462425 4.957851492942075 1.000017755175268 0.7178682918988586 0.8049235374056952 0.06547428461458009 1.2850437211490569e-05 2.196233824407676e-06 0.06339919029985835 0.02113173449274286 7.036690108318723e-11 10.15263157462425 -0.28214946327640944 SHFIVALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHFIVALK 8 0 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;J3KT86;J3QR41;Q96GD4-3;J3KRJ2 Q96GD4-5 AURKB Aurora kinase B 0 20553300.0 7835300.0 6116400.0 6601600.0 False True 10732222.151020866 5846157.22376998 5042438.044219784 1.0 0.5447294270938926 0.4698410052702962 23.355445487215476 -13.999999999999998 0.25398373950784076 4.230867264608397 0.44085038115615155 0.9995503182922632 0.004967887308095113 14.159438199848434 0.1594696446318938 23.395262052828755 0.033811580820745084 1.0000000000000041e-14 13.999999999999998 -3.7900168834522456 SHFIVALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SHFIVALK 8 0 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;J3KT86;J3QR41;Q96GD4-3;J3KRJ2 Q96GD4-5 AURKB Aurora kinase B 0 26833500.0 6151000.0 12685000.0 7997500.0 False True 7962590.754336768 11979068.598988835 6542037.061279681 1.0 1.5044184698886505 0.8215965460383113 22.924806480031943 -6.708803831372398 1.7992330835798505 1.3104893866981946 0.823244106298279 0.4594210196531142 0.21260080858086325 0.37754039711710663 2.381647744891112 0.0940533031970622 0.23930791284836564 1.9552224204533982e-07 6.708803831372398 -0.48724528039991555 SHFVAASLSNQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHFVAASLSNQK 12 0 Q86XP3;A0A0A0MSJ0;Q86XP3-2 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 19973100.0 6737700.0 5173700.0 8061700.0 False True 8833189.947979622 4401804.126924649 7227552.617286923 1.0 0.4983255373028014 0.8182267855498851 23.074503104711386 -10.434442821986055 6.785883883323705 1.0000496443623408 0.6582761614263457 0.6034026574244757 0.13059913771412782 9.810277816958018e-05 8.176065046779558e-06 0.12647036461454195 0.042150690449655505 3.6775380764335465e-11 10.434442821986055 -0.3417734829359951 SHFVAASLSNQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHFVAASLSNQK 12 0 Q86XP3;A0A0A0MSJ0;Q86XP3-2 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 13885460.0 4414700.0 762360.0 8708400.0 False True 4274557.764984607 1066774.3236548812 6427408.793599943 1.0 0.24956367004639668 1.5036429841352463 22.02734373943594 -6.744623123077009 1.6695680867328115 0.5559034809725173 1.505174476505981 0.6255844907333793 0.31529096687542685 0.309520952808595 1.695689277683436 0.1492868465964962 0.3645227217947467 1.8004326369777017e-07 6.744623123077009 0.9492709955334636 SHFVAASLSNQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SHFVAASLSNQK 12 0 Q86XP3;A0A0A0MSJ0;Q86XP3-2 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 13683600.0 3408000.0 7035100.0 3240500.0 False True 5170185.158173406 5779631.439512812 2600013.754638392 1.0 1.1178770706840062 0.502886004097571 22.30178451756172 -6.857053007981726 1.2005724088003993 1.063517060953636 0.47474331322711477 0.9499547181927179 0.05961963910230686 0.14986610343867082 0.4121607554977657 0.038776239358355745 0.09023379639170843 1.3897829903579102e-07 6.857053007981726 -0.5887737477265211 SHFVAASLSNQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHFVAASLSNQK 12 0 Q86XP3;A0A0A0MSJ0;Q86XP3-2 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 15916400.0 6737700.0 3581400.0 5597300.0 False True 9228809.769496173 3423161.9058939554 4275333.020012023 1.0 0.370921277108612 0.4632594155470848 23.137713166234278 -10.766873918304519 7.088802603490631 1.0129722847438676 0.4170903463278484 0.9815275916664061 0.03769688716212203 0.00756135289863529 0.00024866632512804334 0.03571033495395888 0.012166618015229905 1.710511828258902e-11 10.766873918304519 -0.5958819384160192 SHFVAASLSNQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SHFVAASLSNQK 12 0 Q86XP3;A0A0A0MSJ0;Q86XP3-2 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 8689200.0 4414700.0 2680200.0 1594300.0 False True 3671018.654370615 2665761.2306219516 1927660.758789675 1.0 0.7261639020679367 0.5251024144196746 21.807749014870215 -7.437689944708488 0.13176551452099722 1.3392360797766343 1.9614892648249574e-09 0.9999934012240198 0.0004999427029624582 0.12632873727047436 0.010305819111690668 0.03726279399281208 0.06194534262455291 3.6501444821253234e-08 7.437689944708488 -1.339236077815145 SHFVAASLSNQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SHFVAASLSNQK 12 0 Q86XP3;A0A0A0MSJ0;Q86XP3-2 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 12664200.0 3408000.0 7081000.0 2175200.0 False True 4411723.181723247 6686936.12530074 1779335.9194367684 1.0 1.5157197879058177 0.4033199378438219 22.07291083965417 -6.780633798984255 1.533331376053152 1.291771134947599 0.3943208899768857 0.7696538808331008 0.21815180505645268 0.2495883598592741 1.1590890666013256 0.11205115972380233 0.26426168184684934 1.6571667123973563e-07 6.780633798984255 -0.8974502449707134 down SHGFAAEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHGFAAEFK 9 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 14754600.0 3242600.0 2106600.0 9405400.0 False True 3139665.4379095 2947776.3657738743 6941843.584048148 1.0 0.9388823185366552 2.2110137915427934 21.582179403350445 -6.895617165184924 0.9885762675758004 0.9405633313637954 2.3332641246618517 0.9842562487465955 0.07350455757008613 0.11470315692586788 0.19617881788850455 0.05619419099665639 0.1432413568619555 1.2716946224563543e-07 6.895617165184924 1.3927007932980562 up SHGFAAEFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SHGFAAEFK 9 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 19503300.0 5773700.0 9804100.0 3925500.0 False True 8759125.014009912 8054481.755217079 3149623.204392226 1.0 0.9195532364630279 0.35958194446985453 23.062355329447794 -6.932779774419011 0.7236138445162497 1.007699441472689 0.23603927394067264 0.9970568653939714 0.01545244485776554 0.09122005396487912 0.07079687358078172 0.014318297861103085 0.04991593854430552 1.1674014424204028e-07 6.932779774419011 -0.7716601675320163 down SHGFAAEFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHGFAAEFK 9 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 23831400.0 10842000.0 5893800.0 7095600.0 False True 14850580.394033186 5633392.427809741 5419765.418469138 1.0 0.3793381994735493 0.36495310450268637 23.824015980101606 SHGFAAEFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SHGFAAEFK 9 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 12423000.0 3242600.0 4790600.0 4389800.0 False True 2696365.5715364898 4764792.086940356 5307686.883858072 1.0 1.767116498311169 1.968459670264056 21.36258467878472 -10.910430901605885 0.26054696776015335 1.952805069208096e-12 2.0576416955498344 0.9992074114422496 0.011746977381970005 2.7880863214612335 0.13584282091345615 1.7837670617852677 0.08704316965198955 1.2290487187361414e-11 10.910430901605885 2.057641695547882 SHGIDLDHNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHGIDLDHNR 10 0 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 4371650.0 630350.0 1592000.0 2149300.0 False True 826394.9543180839 1354479.8055673952 1926911.0535414056 1.0 1.6390223566709345 2.331707186101389 19.656471920069478 -6.970094454654282 0.25592013124865853 0.7955806400332908 3.1955912452091533 0.9999831100448004 0.0022349273910332963 0.07627206311341328 0.008920419030124653 0.014850061042977845 0.0657640738952767 1.0712862859742414e-07 6.970094454654282 2.4000106051758623 SHGIDLDHNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHGIDLDHNR 10 0 E9PD53;Q9NTJ3;Q9NTJ3-2;C9JR83;C9J9E4;C9JVD8;C9J578 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 0 3437450.0 630350.0 1473400.0 1333700.0 False True 863407.4295682372 1408300.316117763 1018707.5284137066 1.0 1.6310958973586893 1.1798688469974483 19.71968198159237 -10.185013913438821 4.4959833430596055 0.9999125081953687 1.4054823721846144 0.5184654910303671 0.18421267194599594 0.0001622733034859019 2.941553088797366e-05 0.17840164838503347 0.05945438421376075 6.531096287195791e-11 10.185013913438821 0.40556986398924566 SHGK(ub)DEECVLEAENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHGKDEECVLEAENK 15 1 C9IYK6;C9JTE9;H7C5E2;A0A669KBH7;A0A669KB27;A0A669KAY5;Q9UHQ4;Q9UHQ4-2;B7Z2L0;H0Y7N8 C9IYK6 BCAP29 B-cell receptor-associated protein 29 1 8041000.0 2569000.0 2314700.0 3157300.0 True False 3367983.878231389 1969355.7826299325 2830612.882960164 1.0 0.5847283876145184 0.8404472780453416 21.683453801893776 -10.350326044302909 5.992811342330966 1.0000367393694969 0.7125878328299299 0.6274655311622372 0.10439679985770042 5.125157451449765e-05 5.556042019790641e-06 0.10109466228182445 0.033693922270518414 4.463483726364499e-11 10.350326044302909 -0.287448906539567 SHGK(ub)DEECVLEAENK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHGKDEECVLEAENK 15 1 C9IYK6;C9JTE9;H7C5E2;A0A669KBH7;A0A669KB27;A0A669KAY5;Q9UHQ4;Q9UHQ4-2;B7Z2L0;H0Y7N8 C9IYK6 BCAP29 B-cell receptor-associated protein 29 1 5834400.0 2569000.0 1672600.0 1592800.0 True False 3518828.724614579 1598699.0014514532 1216613.444745709 1.0 0.45432702940850306 0.3457438653479691 21.746663863416668 -13.999999999999998 0.22697584309145732 4.397159924366491 0.2914074089312625 0.9995058162361496 0.006364046879594388 13.198917176285368 0.150871857763347 20.17344917519011 0.05744426585172474 1.0000000000000041e-14 13.999999999999998 -4.105752515435229 SHGK(ub)ETHLDSQTHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHGKETHLDSQTHR 14 1 A0A0A0MR27;J3QT39;Q49A88-2;Q49A88-3;Q49A88-6;Q49A88;Q49A88-4 A0A0A0MR27 CCDC14 Coiled-coil domain-containing protein 14 1 6538100.0 1480400.0 2774400.0 2283300.0 True False 1433405.512329989 3882232.3883048673 1685235.2324682774 1.0 2.7083978364184813 1.1756863064722984 20.451015377016848 -6.620180095796819 2.1163725119699643 2.133439033616911 1.1815745228006593 0.08331067318712981 0.7346394247030718 0.5849132073397241 4.978660383718382 0.28521978813784193 0.814425290041168 2.397838363066971e-07 6.620180095796819 -0.9518645108162518 SHIFFWTWSGNSLTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SHIFFWTWSGNSLTR 15 0 B5MBZ0;Q9HC35-2;Q9HC35 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 0 15062100.0 4895700.0 4025900.0 6140500.0 False True 7427134.823611966 3307446.6904997313 4926827.483523243 1.0 0.44531932825359066 0.6633550622859472 22.824374336888653 -10.21160430590086 5.46600119683841 1.0000218592160037 0.5543371952697292 0.847805169930357 0.08901271567889144 2.3712578900537322e-05 3.4203668388074414e-06 0.08619041136991527 0.028728730452065372 6.143214704253202e-11 10.21160430590086 -0.4456846639462745 SHISDQSPLSSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHISDQSPLSSKR 13 1 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 7574000.0 1697800.0 2825600.0 3050600.0 True False 1643904.2683287342 3953876.815309336 2251556.343961689 1.0 2.4051746147779163 1.3696395753328878 20.648694856404152 -10.155259054525478 5.285301552316283 0.9999695622790113 1.8874070950558226 0.494735870470164 0.4227554095703337 0.00015163113460025374 2.4234430471749313e-05 0.4093451491727801 0.1364437217318708 6.994246681682104e-11 10.155259054525478 0.8874375327768113 SHISDQSPLSSK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SHISDQSPLSSKR 13 1 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 1 8388900.0 2332900.0 1594800.0 4461200.0 True False 3019985.0383339706 1506047.9780581289 3649307.3757775463 1.0 0.498693854089081 1.2083859123324507 21.526109971465637 -6.716929859345469 1.7703942052475907 0.6940139925521204 1.2070907210469695 0.49796578162656946 0.21103496006247996 0.3613224029474556 2.211555810679279 0.09471119139363283 0.23862052324413288 1.9189786399549542e-07 6.716929859345469 0.5130767284948491 SHKDEVVK(ub)IQSLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHKDEVVKIQSLAR 14 2 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 7165000.0 1894100.0 3193300.0 2077600.0 True False 2483183.442490494 2716872.0873859064 1862629.8817464418 1.0 1.0941084902938285 0.7500975763104832 21.243759412311203 -6.8337956362947105 1.3108866463152244 1.0501671422612506 0.7401027449723346 0.9132588362451547 0.042753245705689474 0.1761665364244705 0.5907058481019996 0.025596856909643244 0.05890798728842167 1.4662376384983688e-07 6.8337956362947105 -0.310064397288916 SHKDEVVK(ub)IQSLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHKDEVVKIQSLAR 14 2 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 10510400.0 2761900.0 3345400.0 4403100.0 True False 2674224.9962876234 4681235.6660305355 3249796.0198314153 1.0 1.7505017986628115 1.2152290941647779 21.350689421207502 -10.342608826836676 5.637373503722868 0.9999049687268846 1.482865446413798 0.5203900491144601 0.218524166543303 0.0002610536704537457 3.0442015884073686e-05 0.2116264302542069 0.07052837148050395 4.5435067036596476e-11 10.342608826836676 0.4829604776869134 SHKDEVVK(ub)IQSLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHKDEVVKIQSLAR 14 2 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 5434700.0 1894100.0 2446200.0 1094400.0 True False 2594399.9561278624 2338118.7954983497 835925.2598755037 1.0 0.9012175589873151 0.32220369796919085 21.306969473834094 -6.936330814648376 0.6928540187382604 1.0070920752731867 0.18158774459492985 0.9976427823172204 0.014515124161005012 0.08948104592966456 0.06253474175003787 0.013763665806767172 0.050692216550380254 1.1578950180737534e-07 6.936330814648376 -0.8255043306782568 down SHKDEVVK(ub)IQSLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SHKDEVVKIQSLAR 14 2 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 7558880.0 2761900.0 4224100.0 572880.0 True False 2296642.222915756 4201343.934881793 692666.5593021575 1.0 1.8293419379653653 0.3015996799112952 21.131094696641778 -6.75929369635094 1.6151978340644408 1.482159075430711 0.29622806253072276 0.6880295071354124 0.3487886165550424 0.28411703119487214 1.4607301490100177 0.17039477348393678 0.4097603188925214 1.740629355812485e-07 6.75929369635094 -1.1859310128999883 SHLDEEEEQQK(ub)QK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHLDEEEEQQKQK 13 1 H0Y5D3;H0Y3M0;Q13371-2;Q13371 H0Y5D3 PDCL Phosducin-like protein 1 6539700.0 2470600.0 2798200.0 1270900.0 True False 2392172.155338067 3915535.852420225 938013.1638172519 1.0 1.6368119007165989 0.392117750273157 21.189889787754527 -6.767636163725317 1.583560887351825 1.3663600205828728 0.3857425634770666 0.7214206041794855 0.2682258420789163 0.2702665480471977 1.337181599050802 0.133541474419765 0.3185708959164569 1.7075122822524954e-07 6.767636163725317 -0.9806174571058062 SHLDEEEEQQK(ub)QK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SHLDEEEEQQKQK 13 1 H0Y5D3;H0Y3M0;Q13371-2;Q13371 H0Y5D3 PDCL Phosducin-like protein 1 6067930.0 2470600.0 2987100.0 610230.0 True False 2054413.3661376846 2971007.8994070715 737826.27161527 1.0 1.4461587664767743 0.3591420712971654 20.970295063188804 -6.795249448318491 1.4753337332891152 1.2476532723860478 0.3458507344437034 0.8179266231141571 0.1903678592469998 0.2275806522815462 0.9783842012621021 0.10153894123494911 0.23684726581415824 1.6023247894591037e-07 6.795249448318491 -0.9018025379423444 down SHLEPEEK(ub)QALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHLEPEEKQALK 12 1 Q9BW71-3;Q9BW71-2;Q9BW71 Q9BW71-3 HIRIP3 HIRA-interacting protein 3 1 5945700.0 1532400.0 2165200.0 2248100.0 True False 1483754.8007933516 3029775.651368837 1659255.168445639 1.0 2.041965188418491 1.1182812467116863 20.50082126714051 -6.617095692829691 2.1267036219114543 1.6927371494653125 1.1216926881068594 0.07336897352828486 0.44840378325915903 0.5932249254303753 5.09396531331107 0.17346104584261113 0.49756212575717057 2.414928668302587e-07 6.617095692829691 -0.5710444613584531 SHLMSLYSACSSEVPHGPVDQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHLMSLYSACSSEVPHGPVDQK 22 0 O95816;O95816-2 O95816 BAG2 BAG family molecular chaperone regulator 2 0 6877000.0 1218900.0 3052100.0 2606000.0 False True 1597989.70384439 2596738.576992621 2336356.118517152 1.0 1.6250033218270896 1.4620595570149324 20.60782668205784 -10.020615784163944 4.530119835318962 0.999981886860744 1.5435314393558224 0.936852162125365 0.06652151358994975 22970387.66730332 0.13358038917070314 4764.173909012066 0.022772083445886434 9.536394659100326e-11 10.020615784163944 0.5435495524950784 SHMMDVQGSTQDSAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHMMDVQGSTQDSAIK 16 0 P13667 P13667 PDIA4 Protein disulfide-isomerase A4 0 10362500.0 2170400.0 3881200.0 4310900.0 False True 2845415.4181834995 3302140.088799107 3864849.42107275 1.0 1.1605124748031268 1.35827246748387 21.440207864387464 -6.968321066415529 0.2955554385940702 0.9638388009622745 1.5611038574805534 0.9999661603305526 0.0008523576176722262 0.07685138638930407 0.010970102105109509 0.0033554358650054214 0.017821591724921995 1.0756696955673773e-07 6.968321066415529 0.5972650565182789 SHMMDVQGSTQDSAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHMMDVQGSTQDSAIK 16 0 P13667 P13667 PDIA4 Protein disulfide-isomerase A4 0 11574800.0 2227200.0 1135900.0 8211700.0 False True 2156498.755107645 1589470.7936402473 6060809.424280529 1.0 0.7370608445173465 2.810485936950144 21.04025945256536 -6.8750730355914085 1.106863202575562 0.845577341257764 2.944247680361773 0.9694913815314381 0.16099398866888553 0.13208612786876692 0.2993954284785609 0.11249329537354712 0.268951470558475 1.333297191834423e-07 6.8750730355914085 2.098670339104009 up SHMMDVQGSTQDSAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHMMDVQGSTQDSAIK 16 0 P13667 P13667 PDIA4 Protein disulfide-isomerase A4 0 11758700.0 2170400.0 4748500.0 4839800.0 False True 2972855.5328546073 4538695.568810369 3696738.918809818 1.0 1.5267124549615112 1.2434976667904614 21.503417925910355 -10.151053697923286 4.777410237583777 0.9999661300738103 1.3851050608784052 0.7114225967882086 0.11562195311323525 4.1714704791709776e-05 7.412369729269609e-06 0.1119603035945261 0.03731682490411328 7.06230227707481e-11 10.151053697923286 0.38513893080459494 SHMMDVQGSTQDSAIKDFVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHMMDVQGSTQDSAIKDFVLK 21 1 P13667 P13667 PDIA4 Protein disulfide-isomerase A4 0 10667200.0 1770700.0 5354000.0 3542500.0 False True 2321404.8474831926 4555204.069728545 3175956.0820594756 1.0 1.9622618065380453 1.368118139971477 21.146566716531783 -10.200489722219965 5.7534490140758345 0.9999832915205353 1.6651899732547715 0.6256465320274593 0.2425581361657923 5.199494465741072e-05 7.22534268433053e-06 0.234861794256494 0.07828530182142679 6.302462608839964e-11 10.200489722219965 0.6652066817342361 SHMMDVQGSTQDSAIKDFVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHMMDVQGSTQDSAIKDFVLK 21 1 P13667 P13667 PDIA4 Protein disulfide-isomerase A4 0 9032100.0 1770700.0 3357500.0 3903900.0 False True 2425375.641368251 3209154.5482322383 2981879.223344279 1.0 1.3231577383294848 1.2294504704690126 21.209776778054675 -10.17599045935125 4.6791200091494405 0.9999614745424203 1.2763041044014158 0.920585924776633 0.03825583191550135 26829719.271188255 0.7390331069665906 11136.390821217024 0.013095988809039668 6.66821417889379e-11 10.17599045935125 0.2763426298589955 SHSAHFFEFLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHSAHFFEFLTK 12 0 P30046;B5MC82;P30046-2;A6NHG4;J3KQ18 P30046 DDT;DDTL D-dopachrome decarboxylase;D-dopachrome decarboxylase-like protein 0 150470000.0 63619000.0 43344000.0 43507000.0 False True 83405125.08727239 36877244.153588735 39005312.98861303 1.0 0.4421460205832866 0.46766086553792885 26.313632701488377 -10.468760961170528 6.090755329473334 1.0003168300981449 0.45490344306061115 0.9983594581147609 0.010416391834183417 4.4839465093970697e-05 3.910914118021407e-06 0.010091289623080457 0.0033618760084469105 3.39812256255021e-11 10.468760961170528 -0.5454133870375337 SHSAHFFEFLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHSAHFFEFLTK 12 0 P30046;B5MC82;P30046-2;A6NHG4;J3KQ18 P30046 DDT;DDTL D-dopachrome decarboxylase;D-dopachrome decarboxylase-like protein 0 203785000.0 54829000.0 22616000.0 126340000.0 False True 53088483.40687718 31646686.74088199 93247763.88124302 1.0 0.596112088912723 1.7564593655196323 25.661895592400825 -6.812682458521246 1.4032070617867805 0.7805737442608796 1.7780339112919474 0.8667254803408273 0.1755770906441099 0.20316197418763465 0.7878845095791565 0.09837235377331423 0.22729382166944162 1.5392796983544826e-07 6.812682458521246 0.9974601670310679 SHSAHFFEFLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SHSAHFFEFLTK 12 0 P30046;B5MC82;P30046-2;A6NHG4;J3KQ18 P30046 DDT;DDTL D-dopachrome decarboxylase;D-dopachrome decarboxylase-like protein 0 74920000.0 22441000.0 27507000.0 24972000.0 False True 34044637.65685725 22598160.936828036 20036273.25438358 1.0 0.6637803334727613 0.588529490498128 25.020924242622424 -13.999999999999988 0.21034350487142867 2.947228375945696 0.5443540976760093 0.9994902064780119 0.004039080502100024 12.754727007953624 0.14536448194906995 10.26601779458312 0.04446777139326929 1.0000000000000286e-14 13.999999999999988 -2.4028742782696866 SHSAHFFEFLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHSAHFFEFLTK 12 0 P30046;B5MC82;P30046-2;A6NHG4;J3KQ18 P30046 DDT;DDTL D-dopachrome decarboxylase;D-dopachrome decarboxylase-like protein 0 163168000.0 63619000.0 57234000.0 42315000.0 False True 87140663.53883025 54705212.63247182 32321068.504780702 1.0 0.6277805379355982 0.3709068440863811 26.37684276301127 -8.11808693560682 0.18397575150571166 1.2945559843539367 5.55456352819114e-13 0.999864157553844 0.00301006664021578 0.09036392758293403 0.035205763466551555 0.09757195715680005 0.11327656893654496 7.619264748831221e-09 8.11808693560682 -1.2945559843533812 down SHSAHFFEFLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SHSAHFFEFLTK 12 0 P30046;B5MC82;P30046-2;A6NHG4;J3KQ18 P30046 DDT;DDTL D-dopachrome decarboxylase;D-dopachrome decarboxylase-like protein 0 99120000.0 54829000.0 25295000.0 18996000.0 False True 45592742.83654295 25158730.81433559 22967975.772419695 1.0 0.551814373277202 0.5037638523912336 25.4423008678351 -13.999999999999998 0.31538723677928393 5.4716202699230845 0.4937255768894181 0.9996837694447189 0.003973845711292459 17.66213310639843 0.17889709395046927 51.98293459723928 0.016291923203063007 1.0000000000000041e-14 13.999999999999998 -4.977894693033666 SHSAHFFEFLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SHSAHFFEFLTK 12 0 P30046;B5MC82;P30046-2;A6NHG4;J3KQ18 P30046 DDT;DDTL D-dopachrome decarboxylase;D-dopachrome decarboxylase-like protein 0 114639000.0 22441000.0 64307000.0 27891000.0 False True 29050316.87824281 60728258.919603854 22815124.185827054 1.0 2.0904508262037647 0.7853657597420015 24.792050564714874 -6.6849929840867 1.8841362667207622 1.6868060022370623 0.7901140860208614 0.34720724892218124 0.46165942758234785 0.4274769172227367 2.9381109771662692 0.19630574569744821 0.5144571227991324 2.0654135217540393e-07 6.6849929840867 -0.8966919162162009 SHSIFLINVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHSIFLINVK 10 0 P33176 P33176 KIF5B Kinesin-1 heavy chain 0 21250100.0 6486800.0 5140100.0 9623200.0 False True 8504257.618260568 4373217.115952873 8627483.576252585 1.0 0.5142385511185109 1.014489913584864 23.019753870209833 -10.89240932451949 11.721162674745882 1.0129167544608044 0.7643642323516875 0.22829480422350823 0.20422676352910693 0.06484349617391487 0.0005952092241035167 0.18600549942141814 0.06591390449983923 1.2811225496419497e-11 10.89240932451949 -0.24855252210911694 SHSIFLINVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHSIFLINVK 10 0 P33176 P33176 KIF5B Kinesin-1 heavy chain 0 21884500.0 6486800.0 6077200.0 9320500.0 False True 8885145.25917862 5808689.209387041 7119189.861722987 1.0 0.6537528695309164 0.8012463110120402 23.082963931732724 -10.173927976105857 5.240313865449666 1.0000127788119213 0.7274995909821715 0.8198593517147785 0.06021394533975172 8.990167213750081e-06 1.4170982409980948e-06 0.05830463456381759 0.019433967292460178 6.69995713059689e-11 10.173927976105857 -0.27251318782974976 SHSIFLINVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SHSIFLINVK 10 0 P33176 P33176 KIF5B Kinesin-1 heavy chain 0 24698000.0 5401800.0 12811000.0 6485200.0 False True 6992736.585396899 12098056.588225922 5304960.1437713 1.0 1.7300889916961246 0.7586386358167383 22.73742572958157 -6.705587592694014 1.8111195446125437 1.45082504755079 0.7612111883811279 0.44425939004408865 0.3078712596970281 0.3838989761286569 2.45186942381766 0.1354273268932935 0.3458785134668309 1.969755887811361e-07 6.705587592694014 -0.6896138591696621 SHTDQLVLIFAGK(ub)ILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHTDQLVLIFAGKILK 16 1 Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UMX0-2 UBQLN1 Ubiquilin-1 1 6551800.0 2689900.0 1704800.0 2157100.0 True False 2604510.5968768178 2385535.5304145548 1592090.7983871214 1.0 0.9159246782390345 0.6112821350376793 21.312580876265173 -6.947149153793381 0.5893224469888627 1.0035283739177563 0.5083673768684481 0.9989580526135851 0.0053903706348052425 0.08465135735272382 0.04086046536512011 0.0055923013247084164 0.025516235823601425 1.1294079649757602e-07 6.947149153793381 -0.49516099704930816 SHTFPELAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHTFPELAYR 10 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 7351900.0 1188400.0 2965100.0 3198400.0 False True 1558003.9084819718 2522718.637869275 2867460.2492192066 1.0 1.6191991715394765 1.8404705107659791 20.571267421941013 -10.973735104860422 0.20061782028996042 3.3867351943186423e-15 2.0145135066480337 0.999378019532927 0.008871212750007268 3.031156325777547 0.11093763087677234 1.5427153308374821 0.1372684614873576 1.0623433291406526e-11 10.973735104860422 2.01451350664803 SHTFPELAYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHTFPELAYR 10 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 2359700.0 1213300.0 1146400.0 0.0 False True 1174784.4556268435 1604163.4983970243 0.0 1.0 1.365496019898452 0.0 20.16396465094531 -6.865805937138931 1.3707083777045996 1.1922504657648032 4.159701859157506e-22 0.9154203217461565 0.1678570742335339 0.16038902963559457 0.6058940597880058 0.09891412329583704 0.20495360202250085 1.3620531748594035e-07 6.865805937138931 -1.1922504657648032 down SHTFPELAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHTFPELAYR 10 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 7583900.0 1188400.0 2451500.0 3944000.0 False True 1627783.5953024402 2343184.6239735954 3012508.429229703 1.0 1.4394939417842176 1.8506811580626492 20.634477483463904 -6.9719279721566 0.20702447782039715 0.7763765700268891 2.52523916435652 0.9999937707819793 0.0008669188653191258 0.07568195889084825 0.006743409948593465 0.012609125354054262 0.04290722374218364 1.0667730311212091e-07 6.9719279721566 1.7488625943296308 SHTTALECK(ub)TVSPDEITTRPMDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SHTTALECKTVSPDEITTRPMDK 23 2 E9PPJ1;Q8NG31-3;Q8NG31-4;Q8NG31-2;Q8NG31 E9PPJ1 CASC5 Protein CASC5 1 16119600.0 2540000.0 3011600.0 10568000.0 True False 3288080.0708852834 2844001.8125908338 8644732.436836977 1.0 0.8649429914354592 2.6291125065301304 21.64881400108786 -6.888427666032985 1.0316641620667546 0.9016048984694145 2.776240450425949 0.9798717568338423 0.11374077170905848 0.12042711870021591 0.2293863622922267 0.08417456906559428 0.20869034329188857 1.2929220256501278e-07 6.888427666032985 1.8746355519565345 up SHVATCSK(ub)YQNYIMEGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHVATCSKYQNYIMEGVK 18 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 13203400.0 4731700.0 5666500.0 2805200.0 True False 6203304.521847975 4821080.287844003 2514944.8133784737 1.0 0.7771793680068756 0.4054201763787129 22.56460551825065 -6.963428678363963 0.38406795229405744 1.0243966010348509 0.1449712942294296 0.9998769981165604 0.0027200969887655425 0.0784983139601672 0.016765692564363856 0.0048197649617019705 0.031353553932254814 1.0878557751370104e-07 6.963428678363963 -0.8794253068054213 down SHVATCSK(ub)YQNYIMEGVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHVATCSKYQNYIMEGVK 18 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 14402400.0 4162400.0 6017200.0 4222800.0 True False 4030266.890382564 8419899.339283472 3116721.998715469 1.0 2.0891666900214223 0.7733289341589041 21.94244394869332 -6.68687563013957 1.8772690653467983 1.6848104815922633 0.7780042796591694 0.3559838863317567 0.46093427328382663 0.42340066336166127 2.8903914434474567 0.19659426996686938 0.5140175058671699 2.056479430178456e-07 6.68687563013957 -0.9068062019330939 SHVATCSK(ub)YQNYIMEGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHVATCSKYQNYIMEGVK 18 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 11040500.0 4731700.0 3184400.0 3124400.0 True False 6481137.359384503 3043702.6785973953 2386481.069037854 1.0 0.4696247756869711 0.3682194862885134 22.627815579773543 -13.999999999999948 0.2326335509814892 4.389425160219729 0.32013476678961084 0.9995135013283054 0.006110443931904462 13.374750608659204 0.1526991719383239 20.97038753551674 0.051789626320391254 1.0000000000001186e-14 13.999999999999948 -4.069290393430118 SHVATCSK(ub)YQNYIMEGVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SHVATCSKYQNYIMEGVK 18 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 10984800.0 4162400.0 3827900.0 2994500.0 True False 3461220.025585482 3807278.3429213404 3620636.104996353 1.0 1.0999816003541472 1.0460577710265342 21.722849224127597 -10.080203704816455 4.32402152901743 0.9999923048043483 1.073019685699295 0.7097139484443862 0.02201431116843239 15293827.717616253 0.29234409933632916 1171.7509680132557 0.007536084254848119 8.313737257228238e-11 10.080203704816455 0.07302738089494676 SHVLVMSFIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHVLVMSFIGK 11 0 Q9BRS2 Q9BRS2 RIOK1 Serine/threonine-protein kinase RIO1 0 5609000.0 1310400.0 2155600.0 2143000.0 False True 1794890.2922284703 2060358.4643840403 1636867.536470401 1.0 1.1479021716842506 0.9119596576780891 20.775464235269496 -6.737241998613159 1.696762715202323 1.0882829940881762 0.9119028116101532 0.5924597311128994 0.062147813863013136 0.32285530340005253 1.8239801465200713 0.02898841082150341 0.07135230550080542 1.8312937001437702e-07 6.737241998613159 -0.176380182478023 SHVMTK(ub)FAEEEDVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHVMTKFAEEEDVR 14 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 12817900.0 2342200.0 4210200.0 6265500.0 True False 2267848.143055462 5891354.81590295 4624377.58902903 1.0 2.597773062514474 2.039103721820909 21.112892608812587 -9.821198293042057 5.92168205951021 0.999999862227123 2.3184383921701794 0.8813182306527532 0.22807580328156077 4.151374172775892e-07 8.279921834982724e-08 0.22083346997562725 0.0736111489805709 1.5093908291770286e-10 9.821198293042057 1.3184385299430565 SHVMTK(ub)FAEEEDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHVMTKFAEEEDVR 14 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 10300600.0 3798900.0 3837500.0 2664200.0 True False 5203455.991412353 3667946.561084505 2034970.830921345 1.0 0.7049058485625684 0.3910806268525779 22.31103870902849 -7.003079967922324 0.253593965899415 1.096938743244319 3.134458056677066e-12 0.999984947123479 0.0009646163487414771 0.07313916897858745 0.008685445067715876 0.006853701302117911 0.028955574331671965 9.929331998720935e-08 7.003079967922324 -1.0969387432411846 down SHVMTK(ub)FAEEEDVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SHVMTKFAEEEDVR 14 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 12657300.0 2342200.0 6415000.0 3900100.0 True False 1947643.077053221 6380441.12172219 4715592.877975049 1.0 3.2759806952800514 2.4211791850022797 20.893297884246863 -10.321635475657287 5.9017574874470045 0.9998166439240711 2.8485799401411698 0.861796215480877 0.3489712552568436 0.0008419934157466566 9.678118617167798e-05 0.3379213554333578 0.11262998832623551 4.768310462237397e-11 10.321635475657287 1.8487632962170988 SHVMTK(ub)FAEEEDVRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHVMTKFAEEEDVRR 15 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 15692800.0 5255300.0 6324900.0 4112600.0 True False 6889749.192397593 5381249.574267097 3687067.602844829 1.0 0.7810515918641813 0.5351526593904576 22.71602003476896 -6.969620351020684 0.26709574759697413 1.0633213745768868 0.24551893772145159 0.9999792683563918 0.0008645399674092495 0.0764260618732003 0.009469943125889235 0.004907351892350117 0.022962692593884833 1.0724564091771447e-07 6.969620351020684 -0.8178024368554352 SHVMTK(ub)FAEEEDVRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHVMTKFAEEEDVRR 15 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 23698900.0 4638500.0 6141400.0 12919000.0 True False 4491253.356486536 8593693.046977911 9535126.338307552 1.0 1.913428694590651 2.123043520699262 22.09868667773356 -10.744425303152395 0.2937567390776774 2.6394526878963674e-09 2.1916092039839015 0.9991618020756943 0.014115942510038091 2.4535075432495677 0.1470876299348856 1.8118983252885417 0.07733083800805146 1.80125291582294e-11 10.744425303152395 2.191609201344449 SHVMTK(ub)FAEEEDVRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SHVMTKFAEEEDVRR 15 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 52891000.0 6104000.0 11547000.0 35240000.0 True False 9260214.262174428 9486347.63287721 28274798.553759273 1.0 1.024419885361236 3.0533633189519693 23.142614144170413 -6.90952734075603 0.8989469100471894 0.9362369620383589 3.312937047632134 0.990741992785149 0.09258730620843197 0.10473141919739028 0.1404685365610669 0.0756257646563914 0.20808414648682544 1.2316084481035617e-07 6.90952734075603 2.376700085593775 up SHVMTK(ub)FAEEEDVRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHVMTKFAEEEDVRR 15 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 14976000.0 5255300.0 5647100.0 4073600.0 True False 7198326.429142466 5397592.449537541 3111499.5784254894 1.0 0.7498399110778523 0.43225319232934 22.77923009629185 -6.967880849282975 0.304580146891672 1.0521664062989433 0.1199100563206288 0.9999608150363603 0.001454299628358716 0.07699648616478531 0.011478410983481622 0.005152844764289579 0.02834779727263053 1.0767605873994674e-07 6.967880849282975 -0.9322563499783145 down SHVMTK(ub)FAEEEDVRR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SHVMTKFAEEEDVRR 15 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 20186900.0 4638500.0 11175000.0 4373400.0 True False 3857118.2703916696 11114798.056936165 5287857.719683107 1.0 2.8816326795723373 1.3709348142819986 21.879091953167837 -6.591486310155871 2.2234874987636672 2.272334001630608 1.3754198940602538 0.0 0.8150646950972684 0.665108681157703 6.2015204880310915 0.30578001989255305 0.9080240870762422 2.561614010091579e-07 6.591486310155871 -0.8969141075703542 SHVMTK(ub)FAEEEDVRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SHVMTKFAEEEDVRR 15 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 42232000.0 6104000.0 13760000.0 22368000.0 True False 7901748.327828253 12994243.903987877 18297253.51506144 1.0 1.644477065692532 2.315595581628747 22.913740466262862 -6.970615593985486 0.24303399764656483 0.7679077440202748 3.211649296973075 0.9999867936572304 0.0019519372165785528 0.07610347832709788 0.008312232474563613 0.015703571379126455 0.06507922556900078 1.0700015480575275e-07 6.970615593985486 2.4437415529528 SHYADVDPENQNFLLESNLGK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 SHYADVDPENQNFLLESNLGKK 22 1 Q96QD8;F8VUY8 Q96QD8 SLC38A2 Sodium-coupled neutral amino acid transporter 2 1 78372500.0 8403500.0 27583000.0 42386000.0 True False 12748723.87814269 22660598.143037345 34008388.521556266 1.0 1.777479719510458 2.667591583802567 23.603849507623906 -6.969358240103415 0.27307922894681413 0.7868232631201325 3.68511822786476 0.9999769354342387 0.003272020265217976 0.07651150589751518 0.009773006402043831 0.017125247804300147 0.08243989668146626 1.0731038670408957e-07 6.969358240103415 2.8982949647446277 SHYADVDPENQNFLLESNLGKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHYADVDPENQNFLLESNLGKK 22 1 Q96QD8;F8VUY8 Q96QD8 SLC38A2 Sodium-coupled neutral amino acid transporter 2 1 8128900.0 0.0 5411100.0 2717800.0 True False 0.0 4603784.972302602 2436588.1269784756 0.0 SHYADVDPENQNFLLESNLGKK(ub)K(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHYADVDPENQNFLLESNLGKKK 23 2 Q96QD8;F8VUY8 Q96QD8 SLC38A2 Sodium-coupled neutral amino acid transporter 2 2 12525100.0 3122600.0 3628300.0 5774200.0 True False 4277109.605092053 3467989.708816392 4410452.883381885 1.0 0.8108255408483395 1.031176025540959 22.028204747475215 -6.67947940253009 1.9033410550125325 0.8802463216216859 1.030339072274733 0.32168274689009935 0.0801869023805415 0.4398204295730842 3.080008023534489 0.033807298867870435 0.08923693935473838 2.0918021135426708e-07 6.67947940253009 0.15009275065304706 SHYQEAIDIYK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SHYQEAIDIYKR 12 1 A0AVF1-3;A0AVF1;Q96CU4;A0AVF1-2 A0AVF1-3 TTC26 Intraflagellar transport protein 56 1 4098110.0 1220300.0 946410.0 1931400.0 True False 1599825.117402011 805209.3170772862 1731557.2552970138 1.0 0.5033108358649114 1.0823415862534558 20.60948277690782 -6.679594631012719 1.9029203356243614 0.6856377100187219 1.080154222349491 0.32249267737150966 0.21052502946049242 0.439398854014199 3.0757921713148098 0.08877598838467707 0.2342973357340613 2.0912471831435084e-07 6.679594631012719 0.39451651233076923 SHYQEAIDIYK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SHYQEAIDIYKR 12 1 A0AVF1-3;A0AVF1;Q96CU4;A0AVF1-2 A0AVF1-3 TTC26 Intraflagellar transport protein 56 1 4647970.0 777170.0 1456100.0 2414700.0 True False 646251.2894686405 1448255.700286778 2919602.605688659 1.0 2.2410101517593257 4.517751303969094 19.301735728484356 -6.96169786469184 0.41081253519363176 0.8888348944332414 5.9545295633357735 0.9998280633607167 0.019101149773880062 0.07910019455585274 0.018931369480424714 0.029324013574565728 0.19004096654474958 1.0921999072225223e-07 6.96169786469184 5.065694668902532 SHYVLYGLVAAMQPR ddPTM_RPMI8226_Bortezomib_1h_R1 2 SHYVLYGLVAAMQPR 15 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 18399130.0 4661500.0 8955000.0 4782630.0 False True 6111271.642030209 7618948.906316612 4287769.325826428 1.0 1.2467043444636574 0.7016165500380211 22.543041178626005 -6.78364371754585 1.5214560842825564 1.139031159254681 0.6967788426990722 0.780121279276469 0.10450380026603104 0.24496515988017958 1.120186742759665 0.054084245299708185 0.12724475434960292 1.645721271032686e-07 6.78364371754585 -0.4422523165556087 SHYVLYGLVAAMQPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SHYVLYGLVAAMQPR 15 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 22400300.0 9183300.0 7151100.0 6065900.0 False True 8891781.168184286 10006571.52249385 4477058.816900673 1.0 1.1253731207756663 0.5035052856361393 23.0840410125766 -6.8542426003349535 1.214423489637975 1.0672309882964883 0.47653134073445363 0.9462590174273091 0.06224944712404681 0.1528489360706487 0.43166443252418596 0.04006146427100712 0.09299311730161139 1.3988057203416692e-07 6.8542426003349535 -0.5906996475620347 SHYVLYGLVAAMQPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SHYVLYGLVAAMQPR 15 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 33846600.0 8263600.0 12884000.0 12699000.0 False True 12536485.350082675 10584749.536848532 10189037.083830575 1.0 0.8443155510709968 0.8127506872381405 23.57962960416042 -13.999999999996733 0.22432681990399472 1.95768515068139 0.79655100299677 0.9995025887880199 0.0018254908784484766 13.120886057988036 0.15000814230225898 5.579343005015585 0.016983374976992635 1.000000000007522e-14 13.999999999996733 -1.16113414768462 SHYVLYGLVAAMQPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SHYVLYGLVAAMQPR 15 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 21596300.0 2892400.0 7700900.0 11003000.0 False True 3961798.444170961 7360648.774529167 8404318.013898185 1.0 1.8579059177932116 2.121339117153613 21.91772405455115 -10.5995359724197 0.24701037099750514 3.077900660866862e-10 2.2596414162291243 0.9991822148281558 0.013690742188381426 2.2997508508555327 0.1245730813335176 1.5205887114824508 0.12178096708455893 2.5145717235066575e-11 10.5995359724197 2.259641415921334 SHYVLYGLVAAMQPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SHYVLYGLVAAMQPR 15 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 23034760.0 9183300.0 5550500.0 8300960.0 False True 7636320.839169522 5520598.354812013 10036652.356697468 1.0 0.7229395504828473 1.3143308889296212 22.864446288010875 -6.779343865576059 1.5387528459383746 0.842985688483308 1.3188922759117687 0.7649455425492191 0.11713073606921968 0.25159970340331056 1.1766870083284602 0.059960927692731904 0.14154117938190844 1.6620961151903934e-07 6.779343865576059 0.4759065874284607 SHYVLYGLVAAMQPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SHYVLYGLVAAMQPR 15 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 39334300.0 8263600.0 21534000.0 9536700.0 False True 10697393.099908518 20335613.970092647 7801118.454805367 1.0 1.9009878182626152 0.7292541633224716 23.35075592625287 -6.701331566281075 1.826460759688363 1.5587548096926307 0.7326887843398837 0.4237699827419783 0.38022678125988 0.3927449018822259 2.548175611370242 0.1660341816004145 0.42624181069533595 1.989154120368358e-07 6.701331566281075 -0.826066025352747 SIAACHNVGLLAHDGQVNEDGQPDLGK(ub)AR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIAACHNVGLLAHDGQVNEDGQPDLGKAR 29 1 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 57818800.0 7659800.0 10915000.0 39244000.0 True False 11620476.606389863 8967132.970715765 31487406.198743757 1.0 0.7716665395449375 2.7096484305496964 23.47016590537861 -6.877520313624927 1.0935842396143278 0.8626451250153003 2.840598672230925 0.9716274106833956 0.14566721714073 0.12984693709674314 0.28577971398208685 0.10283007574215597 0.24716668883720785 1.325805103301288e-07 6.877520313624927 1.9779535472156247 up SIAACHNVGLLAHDGQVNEDGQPDLGK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIAACHNVGLLAHDGQVNEDGQPDLGKAR 29 1 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 119573800.0 7659800.0 18961000.0 92953000.0 True False 9915762.097231142 17905803.68194146 76036507.77832201 1.0 1.8057919811268406 7.668246477953954 23.24129222747106 -6.931906792878459 0.730968872733822 0.9168547700899401 8.93239062570819 0.9968999326514387 0.16546339804636 0.09165980291651618 0.07291743359507226 0.1524922506508886 0.524999956413102 1.1697504127908444e-07 6.931906792878459 8.01553585561825 SIAADHK(ub)DLIHDVSFDFHGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIAADHKDLIHDVSFDFHGR 20 1 Q96EE3;Q96EE3-1;K7ELV2;K7ENI5;K7EP88 Q96EE3 SEH1L Nucleoporin SEH1 1 40941500.0 3005000.0 13069000.0 24867500.0 True False 3890031.737405624 12341698.6614257 20341870.162097204 1.0 3.172647293015851 5.229229871441562 21.89135049502688 -7.042134367533585 0.21822831772208912 4.508136424540887e-19 8.315943158600906 0.9999932970628753 0.004470667633835534 0.0728011500150159 0.007344086699061787 0.060838323429738966 0.20606183779895723 9.075397005971115e-08 7.042134367533585 8.315943158600906 SIAFHSAVSLDPIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIAFHSAVSLDPIK 14 0 Q9Y3F4;Q9Y3F4-2 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 0 107106300.0 30657300.0 39407000.0 37042000.0 False True 46509365.4488467 32374512.961703707 29720632.463914637 1.0 0.6960858882779383 0.639024681955785 25.471017920779133 -13.999999999999998 0.23520660422897466 2.965910107191353 0.6126206062758909 0.999517328572607 0.003480840452897092 13.45905889277062 0.1535246176419798 12.393322521633042 0.0286897882691818 1.0000000000000041e-14 13.999999999999998 -2.353289500915462 SIAPSIFGGTDMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIAPSIFGGTDMK 13 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 11901100.0 1526900.0 4354300.0 6019900.0 False True 2001780.6865206347 3704655.4129284597 5397018.494958328 1.0 1.8506799660294713 2.696108785193185 20.932852491649506 -6.97120170615861 0.22766176046137937 0.6459517018824177 3.924926005501882 0.9999902988484469 0.0021566956418523726 0.07591466652654072 0.007620092683259881 0.022102251519418675 0.0843538261536727 1.068558476679191e-07 6.97120170615861 3.2789743036194645 SIAPSIFGGTDMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIAPSIFGGTDMK 13 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 10890100.0 1526900.0 4160400.0 5202800.0 False True 2091436.1929209824 3976579.771396999 3974005.7950294907 1.0 1.9013631804100848 1.9001324584897985 20.996062553172397 -10.118352663268597 4.4410573094716375 0.9998905831378392 1.900747819492579 0.999998599665857 0.000502440263936054 76243.93146601696 86855.87758312457 66.02610343932685 0.00017199864895165454 7.614604247223987e-11 10.118352663268597 0.9008572363547399 SIAPSIFGGTDMKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIAPSIFGGTDMKK 14 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 6654300.0 1470700.0 2273000.0 2910600.0 True False 1424013.4335204791 3180620.7535384116 2148226.543871659 1.0 2.2335609192079087 1.5085718247480033 20.44153132544728 -10.101763106391937 4.811422009833751 0.9999658061209972 1.8710663719836749 0.6580924846806875 0.2959755584758674 0.00013182608056489257 2.461117473191315e-05 0.2865907009172585 0.09552570073000227 7.91110035293682e-11 10.101763106391937 0.8711005658626777 SIASHVRPDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIASHVRPDR 10 1 Q86XP3;A0A0A0MSJ0;Q86XP3-2 Q86XP3 DDX42 ATP-dependent RNA helicase DDX42 0 1822090.0 160210.0 780330.0 881550.0 False True 219443.96651245691 745852.4403937646 673346.0460921517 1.0 3.3988286497338067 3.068419044703736 17.7434930790968 -9.981006122332955 5.787614098567464 0.999997172187141 3.233623847219653 0.9838535528765259 0.13488915640949006 4.921906297613361e-06 8.668964978903495e-07 0.1306060312684998 0.043535288029371205 1.0447054917024684e-10 9.981006122332955 2.2336266750325118 SIATLAITTLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIATLAITTLLK 12 0 Q9Y678;Q9UBF2;Q9UBF2-2 Q9Y678;Q9UBF2 COPG1;COPG2 Coatomer subunit gamma-1;Coatomer subunit gamma-2 0 118289000.0 51532000.0 24561000.0 42196000.0 False True 49896144.867190674 34368335.383922964 31143601.747134153 1.0 0.6887974106096109 0.62416849698568 25.57242501693157 -13.999999999999998 0.22093036334837668 2.885626316371794 0.5899050308907285 0.9994988408237832 0.003672981999954903 13.025022899598866 0.14889504637223439 10.72043879502683 0.035548844170593945 1.0000000000000041e-14 13.999999999999998 -2.2957212854810654 SIATLAITTLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIATLAITTLLK 12 0 Q9Y678;Q9UBF2;Q9UBF2-2 Q9Y678;Q9UBF2 COPG1;COPG2 Coatomer subunit gamma-1;Coatomer subunit gamma-2 0 104798000.0 29985000.0 40916000.0 33897000.0 False True 45489437.197133146 33614220.12183285 27197243.09241709 1.0 0.738945614476657 0.5978804040717199 25.43902824968903 -13.999999999823723 0.07548276769497267 2.449593172797984 0.13901877773813195 0.9999046381967654 0.001626728508184419 12.303935173143724 0.07596336809867658 3.0446633530137266 0.4192128529530027 1.0000000004058923e-14 13.999999999823723 -2.3105743950598523 SIATLAITTLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIATLAITTLLK 12 0 Q9Y678;Q9UBF2;Q9UBF2-2 Q9Y678;Q9UBF2 COPG1;COPG2 Coatomer subunit gamma-1;Coatomer subunit gamma-2 0 86452000.0 19061000.0 0.0 67391000.0 False True 26108366.804156702 0.0 51474633.7612117 1.0 0.0 1.971576167415284 24.638008877617253 -6.768809578792081 1.5789574619632185 0.42556040117815064 1.9821862874291911 0.7260174750787874 0.4213222648295053 0.26835246527350426 1.320168017922381 0.21034741257479184 0.5012737601433029 1.7029050022181078e-07 6.768809578792081 1.5566258862510405 SIATLAITTLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIATLAITTLLK 12 0 Q9Y678;Q9UBF2;Q9UBF2-2 Q9Y678;Q9UBF2 COPG1;COPG2 Coatomer subunit gamma-1;Coatomer subunit gamma-2 0 88239000.0 29985000.0 33840000.0 24414000.0 False True 38816173.59271471 31956774.25224926 19970902.508794248 1.0 0.8232850199909227 0.514499515545822 25.21015457178148 -6.962597166514799 0.397138724595586 1.017519397326819 0.3090421440021884 0.9998547271247775 0.0024182232040806497 0.07878607750988324 0.0177965078249401 0.003975278964192214 0.02589931962656511 1.0899406081478325e-07 6.962597166514799 -0.7084772533246306 SIAVWDMASATDITLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIAVWDMASATDITLR 16 0 Q9UKB1-2;Q9UKB1-3;Q9UKB1 Q9UKB1-2 FBXW11 F-box/WD repeat-containing protein 11 0 18343600.0 5052400.0 7499700.0 5791500.0 False True 7664860.179916477 6161319.939576455 4646807.486495372 1.0 0.803839834641784 0.6062481737985216 22.869828044237458 -6.9710350088089825 0.23213996241669482 1.078239046434361 0.3261886103385412 0.9999893666667291 0.0005241508337451015 0.07596829422655041 0.007818124876376722 0.004997931252544948 0.019544160031429038 1.0689687053678757e-07 6.9710350088089825 -0.7520504360958198 SICEVLDLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SICEVLDLER 10 0 H0Y993;P35659;A0A494C028;P35659-2;H0Y8X0;B4DFG0;D6RDA2 H0Y993 DEK Protein DEK 0 8447400.0 1303800.0 3650300.0 3493300.0 False True 1709294.4260171605 3105689.4687579563 3131846.826099754 1.0 1.816942371943812 1.8322453864178876 20.704969492008036 -11.122187975780797 0.6630521033854628 3.747789093498134e-14 1.8298415651633746 0.9999640750820042 0.0023301640243110888 3.3453106420755865 0.33455357022286786 5.016144442599772 0.0024734532724344834 7.547654716423722e-12 11.122187975780797 1.829841565163337 SICMIQK(ub)YNHDGEAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SICMIQKYNHDGEAGR 16 1 A0A3B3IUD2;Q9BUK6-7;Q9BUK6-3;Q9BUK6-2;Q9BUK6 A0A3B3IUD2 MSTO1 Protein misato homolog 1 1 19953700.0 1984500.0 4676200.0 13293000.0 True False 3010631.5863835486 3841695.5746826394 10665632.723471124 1.0 1.2760430708485946 3.5426562226044296 21.521634744335717 -6.929614263199751 0.7499513152622329 0.9650342664311706 4.0034426699997985 0.996461909764632 0.06775837297941255 0.09283854876736894 0.07866487981512545 0.06159016569419364 0.20552602903815997 1.1759415528873805e-07 6.929614263199751 3.038408403568628 up SICMIQK(ub)YNHDGEAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SICMIQKYNHDGEAGR 16 1 A0A3B3IUD2;Q9BUK6-7;Q9BUK6-3;Q9BUK6-2;Q9BUK6 A0A3B3IUD2 MSTO1 Protein misato homolog 1 1 13828900.0 1984500.0 4717600.0 7126800.0 True False 2568974.370343249 4455061.412896312 5829795.527143232 1.0 1.7341790032342974 2.269308559261451 21.292761066428167 -7.39251335480091 0.12362414244875614 4.6334035130754164e-14 3.793486983308925 0.9999958675843519 0.0010576935565361624 0.12379856306103339 0.008941241045997231 0.09889660026605487 0.16339912234663698 4.050294900591325e-08 7.39251335480091 3.793486983308879 SIDLK(ub)DKYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIDLKDKYK 9 2 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25;C9JCQ4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 7268900.0 1039800.0 1338600.0 4890500.0 True False 1577452.619562416 1099716.3714704628 3923890.531417707 1.0 0.6971470064029708 2.4874855084434744 20.589165242329848 -6.863378195240525 1.168647856381986 0.8339847341158341 2.579904593770108 0.9576103127658511 0.16109077120702625 0.14335661317157355 0.3701491586666957 0.1073599609671142 0.25162472156646826 1.369688485334529e-07 6.863378195240525 1.7459198596542742 up SIDNK(ub)ALYDTFSAFGNILSCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIDNKALYDTFSAFGNILSCK 21 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEQ8;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 93662000.0 16379000.0 19632000.0 57651000.0 True False 24848140.465294115 16128516.214483896 46256254.5806691 1.0 0.6490834288791514 1.8615579964736644 24.566634554555282 -6.829287914231767 1.3311524865008006 0.81240206731847 1.8936987346431284 0.9044333728855888 0.1574793432892322 0.18168992122196514 0.6299089132300913 0.09289542568473007 0.21377810602221686 1.4815355799125288e-07 6.829287914231767 1.0812966673246585 SIDNK(ub)ALYDTFSAFGNILSCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIDNKALYDTFSAFGNILSCK 21 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3;E5RJB9;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEQ8;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 85224000.0 16379000.0 26175000.0 42670000.0 True False 21202938.378358327 24718338.24032578 34904497.83117273 1.0 1.1657977681789422 1.646210407648002 24.33776087664773 -6.952228954790373 0.5338137363574347 0.9926246644497215 1.8413351369016573 0.9993647891189753 0.006906692763436054 0.08260287816247179 0.03235242057906246 0.007662818454727763 0.03974802454670334 1.1162746061805747e-07 6.952228954790373 0.8487104724519358 SIDTGMGLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIDTGMGLER 10 0 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 7512210.0 2459700.0 919810.0 4132700.0 False True 2381618.1698717102 1287094.9297457824 3050221.8916575313 1.0 0.5404287496744761 1.280735060827083 21.18351070268215 -6.738800911471268 1.6909978720148688 0.726178369359247 1.281063769469383 0.5995760089363389 0.1930986712982921 0.3199947709829451 1.7961594763714033 0.0903527780018137 0.22201769190906886 1.8247320011202414e-07 6.738800911471268 0.554885400110136 SIEALLEAGQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIEALLEAGQAR 12 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 12124300.0 3666700.0 4047700.0 4409900.0 False True 4807079.208373315 3443798.93781102 3953605.8507478083 1.0 0.716401537926058 0.8224549002357054 22.196729144921036 -10.753362019405541 7.532954919348385 1.0031981097580107 0.7694282190808831 0.8630576834765333 0.043296103860858255 0.002350502020965646 7.695811169534994e-05 0.04237264953673964 0.013973757434064232 1.764566299421203e-11 10.753362019405541 -0.2337698906771276 SIEALLEAGQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIEALLEAGQAR 12 0 Q9P2E9;Q9P2E9-3;A0A087WVV2;F8W7S5 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 10155700.0 3666700.0 3318600.0 3170400.0 False True 5022378.078841685 3171973.278857343 2421616.8164375904 1.0 0.6315680000715711 0.482165376326286 22.259939206443928 -13.999999999940572 0.12426384555083149 2.7519460487240996 0.2568547863933731 0.9996723026558504 0.003939395678242296 11.949400783846547 0.10901459603261417 5.142961403327653 0.20004896647712903 1.000000000136838e-14 13.999999999940572 -2.4950912623307264 SIEIPRPVDGVEVPGCGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIEIPRPVDGVEVPGCGK 18 1 P26368;P26368-2;K7ENG2 P26368 U2AF2 Splicing factor U2AF 65 kDa subunit 0 57641700.0 3748000.0 51007000.0 2886700.0 False True 5685990.015502914 41904402.33048997 2316142.4797144462 1.0 7.369763614821194 0.40734198853664155 22.43898013499507 -6.6660121413266475 1.9513265046097328 5.079547321165182 0.4357769405022259 0.2616317784801706 2.7082271569395786 0.4703046123738438 3.4484180594311997 1.1188241870734317 3.005048994062296 2.1576840871486142e-07 6.6660121413266475 -4.643770380662956 SIEK(ub)LLEWENNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIEKLLEWENNR 12 1 H0Y8H1;Q9UKJ5 H0Y8H1 CHIC2 Cysteine-rich hydrophobic domain-containing protein 2 1 56112800.0 24078900.0 25390100.0 6643800.0 True False 31567671.080399275 21601996.049834613 5956363.3078297125 1.0 0.6843075624684755 0.1886855477130236 24.911944493291468 -7.3000913676594825 0.45818395760464525 1.018152840360648 4.850473222210798e-13 0.9990246679704131 0.01042847911288563 0.10075550800069724 0.04085791036041199 0.013036078617157533 0.05442642354275498 5.010818040401815e-08 7.3000913676594825 -1.018152840360163 down SIEK(ub)LLEWENNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIEKLLEWENNR 12 1 H0Y8H1;Q9UKJ5 H0Y8H1 CHIC2 Cysteine-rich hydrophobic domain-containing protein 2 1 55078100.0 19566000.0 28164200.0 7347900.0 True False 18944888.039886907 39410311.93436273 5423264.557725061 1.0 2.0802610103257173 0.28626532636702956 24.175305278073612 -6.743627737441102 1.673247436297909 1.6400099879924666 0.2843083328854633 0.6212521232065062 0.45385946108675485 0.3112562770268718 1.7123723348836797 0.2144585933395647 0.5242151124999317 1.8045638893173742e-07 6.743627737441102 -1.3557016551070031 SIEK(ub)LLEWENNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIEKLLEWENNR 12 1 H0Y8H1;Q9UKJ5 H0Y8H1 CHIC2 Cysteine-rich hydrophobic domain-containing protein 2 1 72256100.0 24078900.0 17909600.0 30267600.0 True False 32981520.037805345 17118294.652872737 23119016.2607893 1.0 0.5190268560469847 0.7009687920474537 24.97515455481436 -10.088199714129763 5.115826480686213 1.0000084421872864 0.60999782404627 0.8596772011700596 0.07427748433918173 7.1520660160651555e-06 1.2749638411647512e-06 0.07192042031961456 0.023972954986511603 8.162069451152633e-11 10.088199714129763 -0.39001061814101634 SIEK(ub)LLEWENNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIEKLLEWENNR 12 1 H0Y8H1;Q9UKJ5 H0Y8H1 CHIC2 Cysteine-rich hydrophobic domain-containing protein 2 1 44797400.0 19566000.0 14423800.0 10807600.0 True False 16269995.9207682 14346096.126499867 13067419.191303588 1.0 0.8817516732249129 0.803160569611661 23.95571055350789 SIEK(ub)LLEWENNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIEKLLEWENNR 12 1 H0Y8H1;Q9UKJ5 H0Y8H1 CHIC2 Cysteine-rich hydrophobic domain-containing protein 2 1 33266000.0 23845200.0 2968200.0 6452600.0 True False 30868081.4591629 2803017.060742505 5278293.009267061 1.0 0.09080632576568687 0.1709951755910068 24.879612482267742 -10.18869114392547 6.576962742609429 1.0000040097865521 0.1309007507588904 0.9936556606195038 0.032736960855451726 1.9248064061796624e-06 2.374245227079865e-07 0.0316975718806082 0.010565808683217184 6.476030061635075e-11 10.18869114392547 -0.8691032590276617 SIELFYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIELFYK 7 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 5398700.0 1548400.0 1104300.0 2746000.0 False True 2029967.3947269286 939542.744527686 2461870.261491979 1.0 0.4628363721349689 1.2127634502342093 20.953025124397907 -6.714439595663551 1.7794713482807012 0.6712719872889655 1.2112360300810854 0.4861353464276873 0.22620722774307458 0.3662115460748372 2.2631140984312372 0.10106164320843185 0.25536257651630834 1.9300137556563146e-07 6.714439595663551 0.5399640427921198 SIELFYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIELFYK 7 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 6224000.0 1548400.0 2166800.0 2508800.0 False True 2120885.3239366333 2071063.6113505946 1916273.110357884 1.0 0.976509002149365 0.9035250933798896 21.0162351859208 -6.950661886300433 0.5515394244503969 1.0010002593355525 0.8755961552943198 0.9992521200854543 0.0011233342727164617 0.08322124927115092 0.03487225578203896 0.0012168424272703644 0.006056399802551172 1.1203097450150956e-07 6.950661886300433 -0.1254041040412327 SIEVAK(ub)TQALAQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIEVAKTQALAQAR 14 1 H0YG27;H0YGS7;Q6PJ69 H0YG27 TRIM65 Tripartite motif-containing protein 65 1 5709010.0 929610.0 2192200.0 2587200.0 True False 1218727.7123560456 1865132.3051286743 2319501.3621748136 1.0 1.5303929550621267 1.9032154095279834 20.21694440495162 -7.495099355583859 0.10039509635440408 3.391070151369832e-20 3.2488843382056496 0.9999973299626315 0.0006055450698484916 0.13440497931041318 0.008707883532122688 0.11185339405191799 0.1603853791173337 3.198163367171448e-08 7.495099355583859 3.2488843382056496 SIEVAK(ub)TQALAQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIEVAKTQALAQAR 14 1 H0YG27;H0YGS7;Q6PJ69 H0YG27 TRIM65 Tripartite motif-containing protein 65 1 5993310.0 929610.0 1751100.0 3312600.0 True False 1273311.9387656513 1673730.6118866657 2530232.10513852 1.0 1.314470210268491 1.9871266640218004 20.28015446647451 -6.958709950508996 0.45325514400023387 0.9790155622212854 2.349392574477492 0.9997193011311191 0.006898338395626832 0.08016530274464347 0.02285924900575839 0.00903546532300998 0.05561400990446132 1.0997400706223339e-07 6.958709950508996 1.3703770122562067 SIEVAK(ub)TQALAQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIEVAKTQALAQAR 14 1 H0YG27;H0YGS7;Q6PJ69 H0YG27 TRIM65 Tripartite motif-containing protein 65 1 8334500.0 2365200.0 2137900.0 3831400.0 True False 1966768.596125983 2126382.7083600736 4632528.025607954 1.0 1.081155511913546 2.3554006479119183 20.907395793915548 -6.919877836769467 0.8256404182412124 0.9717608275809378 2.5603024717875025 0.9941467769982459 0.0474873693867599 0.09824356084725695 0.1059896793875032 0.04088880200355378 0.12233723233826815 1.2026026686321668e-07 6.919877836769467 1.5885416442065647 up SIEVIENR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIEVIENR 8 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 0 15807300.0 1306000.0 9290500.0 5210800.0 False True 1712178.6473219916 7904393.614085353 4671636.401523085 1.0 4.616570605204409 2.7284748637824467 20.70740180853939 -9.763365039397474 8.188554560763269 1.0000001973227073 3.672522734493429 0.727621878072103 0.7708118586676284 2.278161951459662e-09 0.0 0.7463353617984603 0.24877845763990716 1.7243878755685481e-10 9.763365039397474 2.672522537170722 SIEVIENR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIEVIENR 8 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 0 14428600.0 5166900.0 2018900.0 7242800.0 False True 5002879.58771807 2825057.2984244176 5345693.400657486 1.0 0.5646862469686168 1.0685232988179478 22.254327298430212 -6.678136822182149 1.9083125431305168 0.7241157748706792 1.0665876125914553 0.31569531993454114 0.18457142022942472 0.4426801551773334 3.1151244686788733 0.07765160422042923 0.20530566850537713 2.098278727854156e-07 6.678136822182149 0.34247183772077605 SIEVIENR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIEVIENR 8 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 0 13225900.0 1306000.0 6069800.0 5850100.0 False True 1788863.4933229438 5801616.1658555595 4468426.866591453 1.0 3.2431855127629867 2.497913833710713 20.770611870062282 -10.118016306116818 5.528280958685695 0.9999751048021107 2.8705496732372735 0.893610170824597 0.30425588890571603 9.335781658174564e-05 1.4895417958197764e-05 0.2945983918770585 0.0981981658928978 7.620503973752455e-11 10.118016306116818 1.870574568435163 SIEVIENR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIEVIENR 8 0 P49321;P49321-2;P49321-3;Q5T624;P49321-4;H0YF33;H0YDS9;E9PRH9 P49321 NASP Nuclear autoantigenic sperm protein 0 8351900.0 5166900.0 2099300.0 1085700.0 False True 4296506.282480695 2087990.654221576 1312714.850290379 1.0 0.4859740721747583 0.3055307647618405 22.03473257386449 -13.999999999999998 0.14592072538709597 3.471250738565949 0.0973853394060087 0.9995804203453171 0.006026622465426517 11.944731592984025 0.12007979480700551 8.381388054605821 0.18691798056469017 1.0000000000000041e-14 13.999999999999998 -3.37386539915994 SIEVYSAYNNVK(ub)ACLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIEVYSAYNNVKACLR 16 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 40983000.0 12760000.0 10480000.0 17743000.0 True False 16728483.568015786 8916424.850720052 15907124.562874062 1.0 0.5330085548081543 0.9509005701681095 23.995803335645192 -10.328212956083355 8.369309373806301 1.0000006156056271 0.741954562488132 0.33704454763750913 0.17060370086920007 1.959514783626365e-06 1.5764181332422003e-07 0.16518671441770313 0.05506210768898032 4.6966375274465644e-11 10.328212956083355 -0.2580460531174952 SIEVYSAYNNVK(ub)ACLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIEVYSAYNNVKACLR 16 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 32362500.0 15369000.0 8631200.0 8362300.0 True False 14881119.507565275 12077683.17111339 6171962.76637737 1.0 0.811611193967855 0.4147512398673811 23.826979728779712 -6.9590165588173045 0.44907911566037945 1.0129190461843622 0.19773480228485188 0.999731967299214 0.003993499685345412 0.08005431675075388 0.0224436000227489 0.00529722248574207 0.03283140847584811 1.0989639372423194e-07 6.9590165588173045 -0.8151842438995104 down SIEVYSAYNNVK(ub)ACLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIEVYSAYNNVKACLR 16 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 102298000.0 48959000.0 29627000.0 23712000.0 True False 74274382.38233922 24339830.373192456 19025312.806661222 1.0 0.32770155190115613 0.25614905430953827 26.14636136780449 -13.999999999999998 0.3164462909551247 7.749708923817562 0.24137355792014897 0.9996860667292717 0.005936739678044528 17.741759887385708 0.17924406547578725 79.12987548743305 0.024158606584366932 1.0000000000000041e-14 13.999999999999998 -7.5083353658974135 SIEVYSAYNNVK(ub)ACLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIEVYSAYNNVKACLR 16 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 39669000.0 12760000.0 11603000.0 15306000.0 True False 17477716.826034278 11090341.094010025 11691038.036964985 1.0 0.6345417541889791 0.6689110570523931 24.059013397168084 -10.498682492421977 5.694533729583094 1.0004865764572255 0.6517264056206858 0.9927489462948929 0.014031209138424377 8.679499629212619e-05 7.640995228999276e-06 0.013604083970594509 0.004528553276689114 3.1718855437232375e-11 10.498682492421977 -0.34876017083653965 SIEVYSAYNNVK(ub)ACLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIEVYSAYNNVKACLR 16 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 38282600.0 15369000.0 8072600.0 14841000.0 True False 12780004.462142834 8029111.301514353 17944184.482969075 1.0 0.6282557510287523 1.404082802640928 23.607385004213988 -6.776423431640461 1.5498670227171085 0.7885259393913391 1.4095447794028402 0.7544808922670726 0.15698482234041253 0.2561875833328249 1.2152376882102967 0.07979931086398376 0.18885879846625211 1.6733106236967018e-07 6.776423431640461 0.6210188400115011 SIEVYSAYNNVK(ub)ACLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIEVYSAYNNVKACLR 16 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 95665000.0 48959000.0 28097000.0 18609000.0 True False 63378390.6261704 26533377.25075202 15222352.944464339 1.0 0.4186502211338225 0.24018206827389332 25.91748768989694 -13.99999999999991 0.1654052054901126 3.898184430553791 0.07479724791138496 0.999523205330369 0.007083563379932128 12.05010439040433 0.12868533160668125 11.20240266950944 0.1518228691897254 1.0000000000002086e-14 13.99999999999991 -3.823387182642406 SIFDFSALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIFDFSALK 9 0 A0A3B3ITK7;P36871-3;P36871;P36871-2 A0A3B3ITK7 PGM1 Phosphoglucomutase-1 0 3887400.0 1024400.0 1119000.0 1744000.0 False True 1342998.3203037102 952049.5618278363 1563547.6096292825 1.0 0.7088985499345499 1.164221567511489 20.357026069703064 -6.734012523593178 1.7084907963062645 0.8256023772834286 1.164160191959577 0.5777763309459379 0.12233882812880667 0.3287849265728514 1.8818700435009983 0.05670265844972539 0.1400750259307784 1.844962215903058e-07 6.734012523593178 0.3385578146761484 SIFDFSALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIFDFSALK 9 0 A0A3B3ITK7;P36871-3;P36871;P36871-2 A0A3B3ITK7 PGM1 Phosphoglucomutase-1 0 3969650.0 1024400.0 898350.0 2046900.0 False True 1403148.3633690819 858657.9265538143 1563464.3772287748 1.0 0.6119509162182263 1.1142544994135617 20.420236131225955 -6.700452129170231 1.8295361252276858 0.7591348090069857 1.1127573647601519 0.4195414815130487 0.1637880948036437 0.3946122678574196 2.568297638892786 0.07141650209505011 0.1835429529724066 1.993186196311854e-07 6.700452129170231 0.35362255575316615 SIFDFSALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIFDFSALK 9 0 A0A3B3ITK7;P36871-3;P36871;P36871-2 A0A3B3ITK7 PGM1 Phosphoglucomutase-1 0 2130910.0 808450.0 747450.0 575010.0 False True 672261.9954075982 743423.3384927908 695241.9324541511 1.0 1.105853586207929 1.0341830078206637 19.358664067280454 -10.033218161830716 4.444044481739531 0.9999964617415317 1.0700182969666148 0.5599685889032509 0.029259391129487087 20232396.429894663 1.7591210139637086 732.5367121560287 0.010016267833891824 9.263643601463418e-11 10.033218161830716 0.0700218352250831 SIFLFLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIFLFLDR 8 0 A0A0A0MR50;Q13619-2;Q13619;A0A087WWN2;A0A669KAX4;K4DI93;Q13620-3;Q13620-1;Q13620 A0A0A0MR50;A0A669KAX4 CUL4A;CUL4B Cullin-4A;Cullin-4B 0 1963350.0 365630.0 993480.0 604240.0 False True 479344.47076595656 845256.6565547091 541719.0410793556 1.0 1.763359563121803 1.1301247309971663 18.87070326537914 -10.235821394303693 4.370589574015572 0.9997961397090246 1.4467421470682016 0.3989031416008646 0.25851703770800305 28122390.414166223 65862175.5401137 34133.9026719162 0.0884972557857853 5.8100330880295225e-11 10.235821394303693 0.446946007359177 SIFLFLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIFLFLDR 8 0 A0A0A0MR50;Q13619-2;Q13619;A0A087WWN2;A0A669KAX4;K4DI93;Q13620-3;Q13620-1;Q13620 A0A0A0MR50;A0A669KAX4 CUL4A;CUL4B Cullin-4A;Cullin-4B 0 3044420.0 1594400.0 659360.0 790660.0 False True 1543786.6447304357 922645.8865169748 583562.4267084332 1.0 0.5976511648590406 0.37800717391899086 20.558041951555687 -9.924498105380028 0.13776529172771187 1.7103778432859993 6.085620415245171e-05 0.999804783406653 0.0035985277848948265 1.4664207587606128 0.06231247256486896 0.5883629197359451 0.21081530362442988 1.1898765200132417e-10 9.924498105380028 -1.7103169870818469 SIFLFLDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIFLFLDR 8 0 A0A0A0MR50;Q13619-2;Q13619;A0A087WWN2;A0A669KAX4;K4DI93;Q13620-3;Q13620-1;Q13620 A0A0A0MR50;A0A669KAX4 CUL4A;CUL4B Cullin-4A;Cullin-4B 0 3768530.0 365630.0 1156300.0 2246600.0 False True 500813.29177922464 1105210.8426272348 1715999.3501793758 1.0 2.206832088463117 3.4264253332474373 18.933913326902033 -6.970994468461675 0.23321426706752177 0.523516796736187 5.144723493488032 0.9999891340307178 0.0032653284038560867 0.07598130620443465 0.00786606189545108 0.030607946464375414 0.12038662054507146 1.0690684956878501e-07 6.970994468461675 4.621206696751845 SIFLFLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIFLFLDR 8 0 A0A0A0MR50;Q13619-2;Q13619;A0A087WWN2;A0A669KAX4;K4DI93;Q13620-3;Q13620-1;Q13620 A0A0A0MR50;A0A669KAX4 CUL4A;CUL4B Cullin-4A;Cullin-4B 0 3264480.0 1594400.0 785190.0 884890.0 False True 1325814.243896189 780960.0256219876 1069916.4077309142 1.0 0.5890418127708219 0.8069881679553659 20.338447226989963 -10.033637420807526 4.999858784296039 1.0000044494768852 0.6980149903606786 0.7190873184857828 0.08897622692529555 4.413188834565246e-06 8.529713113992211e-07 0.08615213067514024 0.028716953756305133 9.254704985384596e-11 10.033637420807526 -0.30198945911620656 SIFLVAHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIFLVAHR 8 0 A0A087WUC6;E9PI68;Q15005;E9PL01;H0YE04 A0A087WUC6 SPCS2 Signal peptidase complex subunit 2 0 46340000.0 15422000.0 14758000.0 16160000.0 False True 20218391.346860435 12556163.926233446 14487918.217665806 1.0 0.6210268517818159 0.7165712627239026 24.26916487964088 -9.905739915198659 6.525628798957157 1.0000000239528086 0.6687990572528477 0.9412518033398506 0.039005842430533226 1.3606739645546866e-08 2.2422625208079815e-09 0.037767247348413635 0.012589081511513183 1.2423961153636572e-10 9.905739915198659 -0.3312009666999609 SIFLVAHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIFLVAHR 8 0 A0A087WUC6;E9PI68;Q15005;E9PL01;H0YE04 A0A087WUC6 SPCS2 Signal peptidase complex subunit 2 0 11426200.0 9422400.0 2003800.0 0.0 False True 9123291.069561003 2803927.7896789555 0.0 1.0 0.3073373159203476 0.0 23.121122914903957 -8.713528676790716 0.49357814815890316 1.0733539601671707 2.9285568018163816e-20 0.9947895913550514 0.03018907463598782 0.32789268210811157 0.19086530522372516 0.11077621388043153 0.061849340730937584 1.9340661465630746e-09 8.713528676790716 -1.0733539601671707 SIFLVAHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIFLVAHR 8 0 A0A087WUC6;E9PI68;Q15005;E9PL01;H0YE04 A0A087WUC6 SPCS2 Signal peptidase complex subunit 2 0 37690000.0 15422000.0 10997000.0 11271000.0 False True 21123930.163879335 10511116.177784061 8609021.933531454 1.0 0.4975928293759201 0.40754830501439404 24.33237494116377 -13.999999999999998 0.24179769260130266 4.354658175438667 0.36840892227054134 0.9995279790112898 0.005663233975470497 13.687588172330067 0.15562498845901276 22.194579118263864 0.04353923014231965 1.0000000000000041e-14 13.999999999999998 -3.9862492531681255 SIFQHIQSAQSQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIFQHIQSAQSQR 13 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 26980000.0 6011100.0 8786900.0 12182000.0 False True 7880610.31157521 7475928.771067938 10921523.497995352 1.0 0.9486484517686572 1.385872802510433 22.90987593243061 -6.877612599527411 1.0929671302861996 0.9690711078338579 1.415481515948365 0.9717108515800987 0.03282053728292965 0.12976876351868857 0.2852102552878591 0.023178450415978144 0.05572957927554986 1.325523404760987e-07 6.877612599527411 0.44641040811450705 SIFQHIQSAQSQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIFQHIQSAQSQR 13 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 21233300.0 7094000.0 3001300.0 11138000.0 False True 6868804.853059273 4199734.74157274 8220623.667162297 1.0 0.611421467258927 1.1968055350270932 22.71162766653918 -6.7277189867676706 1.731289351880069 0.7655656608089051 1.1963311922067448 0.5487609697807962 0.16338086058802626 0.3405367956040885 1.9985495549282632 0.0748125180834263 0.18614179465126363 1.8718929698099633e-07 6.7277189867676706 0.4307655313978397 SIFQHIQSAQSQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIFQHIQSAQSQR 13 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 44181500.0 9268700.0 27086000.0 7826800.0 False True 14061295.532735297 22252291.6761161 6279829.549391694 1.0 1.5825207303489082 0.4466039089194863 23.745226186968168 -6.767294328085431 1.5846864603993902 1.3352673261009647 0.44083612999753186 0.7201648066935962 0.24534072857204123 0.2708186421965344 1.341733192802839 0.1220605155591637 0.29129653595560384 1.7088568038858758e-07 6.767294328085431 -0.8944311961034328 down SIFQHIQSAQSQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIFQHIQSAQSQR 13 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 26505900.0 6011100.0 9935800.0 10559000.0 False True 8233566.1138694845 9496803.502703175 8065181.669431145 1.0 1.1534253045840928 0.9795490262530722 22.9730859939535 -6.673715778422234 1.9238426558253583 1.0976125980491656 0.9802330880494986 0.2958069405719369 0.06511578799489294 0.4526160086178838 3.2329835471478643 0.02721223043439709 0.07236330165920704 2.119747938506301e-07 6.673715778422234 -0.11737950999966695 SIFQHIQSAQSQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIFQHIQSAQSQR 13 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 15281900.0 7094000.0 5224900.0 2963000.0 False True 5898975.317485926 5196752.426638548 3582549.600635901 1.0 0.8809584965094147 0.6073172725467076 22.492032941973456 -6.957234770560165 0.47280153630975985 1.0070343148077003 0.4699705310699613 0.9996534740278844 0.003060359194569117 0.08070419758017276 0.0248968871442804 0.0038037389341665628 0.022580894286665064 1.1034819392648005e-07 6.957234770560165 -0.537063783737739 SIFYVPDMKPSMFDVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIFYVPDMKPSMFDVSR 17 1 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 8258900.0 1906400.0 3237600.0 3114900.0 False True 2499308.8616038584 2754562.7000659546 2792600.0282306485 1.0 1.1021297697069319 1.1173489083852481 21.253097768295866 -13.999999999786054 0.26806209374622925 0.21986303139161512 1.1224963331744218 0.999579166656298 0.0010688451719836718 14.788036803111318 0.16387191680137198 6.279752049757422 0.0063822100923990755 1.0000000004926293e-14 13.999999999786054 0.9026333017828067 SIFYVPDMKPSMFDVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIFYVPDMKPSMFDVSR 17 1 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 17828100.0 8486900.0 3207300.0 6133900.0 False True 8217488.004994186 4487991.615848541 4527247.576944408 1.0 0.5461512828641746 0.5509284070987349 22.97026601474013 -9.948442840930737 5.665840705732241 1.0000004973522303 0.5485398449809785 0.9999160302577922 0.0019502528037753353 1.2251261891636978e-08 2.2720838394948905e-09 0.0018883262248229446 0.0006294413855814751 1.1260486624842623e-10 9.948442840930737 -0.45146065237125177 SIFYVPDMKPSMFDVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIFYVPDMKPSMFDVSR 17 1 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 12849600.0 1906400.0 3956900.0 6986300.0 False True 2611247.598522859 3782071.074281502 5336279.827364989 1.0 1.4483770426140206 2.0435748147298005 21.316307829818758 -6.967208370643868 0.317876709384876 0.9164299475395637 2.5946599198672344 0.9999516984144361 0.002970679844865187 0.07721934376396014 0.012258212299292026 0.009100954469674368 0.0524543568083916 1.0784291773203692e-07 6.967208370643868 1.6782299723276708 SIFYVPDMKPSMFDVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIFYVPDMKPSMFDVSR 17 1 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 15720800.0 8486900.0 3450300.0 3783600.0 False True 7057233.383418567 3431712.5490690744 4574733.26661019 1.0 0.4862688198936581 0.6482332407142474 22.750671290174406 -10.37084123316004 5.038939229024533 1.0002923770305905 0.5672510303038955 0.904930016165663 0.06612169791617524 0.00021732832330497663 2.7135418391730594e-05 0.06406456595932959 0.02134068623766338 4.257540293585793e-11 10.37084123316004 -0.43304134672669503 SIGEPDSLYGCGGGK(ub)MLQPITR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIGEPDSLYGCGGGKMLQPITR 22 1 Q13315 Q13315 ATM Serine-protein kinase ATM 1 8788000.0 1871700.0 2921400.0 3994900.0 True False 2453816.8255685847 2485538.5075280075 3581546.0697867046 1.0 1.0129274857148607 1.4595816739323273 21.226596126920306 -6.913089784831386 0.8744393394075716 0.9874848559616841 1.521286054373779 0.9920359088414974 0.019068020294277285 0.10241037303588917 0.1279507578087971 0.01585370156623186 0.04475888814750228 1.2215470948148926e-07 6.913089784831386 0.5338011984120948 SIGEPDSLYGCGGGK(ub)MLQPITR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIGEPDSLYGCGGGKMLQPITR 22 1 Q13315 Q13315 ATM Serine-protein kinase ATM 1 8295600.0 1871700.0 3765400.0 2658500.0 True False 2563718.070790623 3599032.1774873193 2030617.0535261608 1.0 1.4038330573444906 0.7920594220798781 21.289806188443197 -6.728682837563939 1.7279808581597471 1.2433807223487998 0.7925069791122491 0.5531628892145146 0.1697802493188169 0.3387174213278598 1.9807716259810253 0.07788062334543758 0.19354816696277877 1.8677431936044415e-07 6.728682837563939 -0.4508737432365507 SIGLK(ub)DLAMADLEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIGLKDLAMADLEQK 15 1 Q12933-3;Q12933;Q12933-2;Q12933-4 Q12933-3 TRAF2 TNF receptor-associated factor 2 1 7782600.0 2310400.0 3190700.0 2281500.0 True False 3028956.773945423 2714659.997251184 2045432.2656933533 1.0 0.8962359650036056 0.6752926562992968 21.530389558992766 -6.958801326932796 0.4520094315691472 1.0069804312593544 0.5557598663807959 0.9997231268717021 0.002253113622570976 0.0801321090668642 0.02273456517077558 0.0029621106568327956 0.018270350495795278 1.0995087074620587e-07 6.958801326932796 -0.45122056487855855 SIGLK(ub)DLAMADLEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIGLKDLAMADLEQK 15 1 Q12933-3;Q12933;Q12933-2;Q12933-4 Q12933-3 TRAF2 TNF receptor-associated factor 2 1 44796100.0 5694700.0 13675000.0 25426400.0 True False 8639276.238336306 11234589.406737339 20400860.895213 1.0 1.300408633408951 2.361408563912486 23.042479023946747 -6.9477361230544625 0.5831674453216622 0.9874621756825921 2.727120182466359 0.999011446347922 0.01836138993593522 0.08440772598880665 0.03982409592339576 0.01917264697561001 0.08870921875526666 1.1278825484689393e-07 6.9477361230544625 1.739658006783767 up SIGLK(ub)DLAMADLEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIGLKDLAMADLEQK 15 1 Q12933-3;Q12933;Q12933-2;Q12933-4 Q12933-3 TRAF2 TNF receptor-associated factor 2 1 9157900.0 2310400.0 3372800.0 3474700.0 True False 3164617.3162123444 3223778.543641908 2654047.4236928164 1.0 1.018694591325934 0.8386629909708586 21.593599620515658 -6.881272656426599 1.072721897040333 1.0117921934251504 0.8255911178829888 0.9746956340041196 0.012856714281741437 0.12650662438481589 0.26554943250331847 0.009221900714034805 0.022373923603104428 1.314399373954023e-07 6.881272656426599 -0.1862010755421616 SIGTANRPMGAGEALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIGTANRPMGAGEALR 16 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EQR9 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 15471100.0 2109500.0 7201400.0 6160200.0 False True 2765574.928427059 6126979.190837335 5522801.59681095 1.0 2.215445015739313 1.9969813654450808 21.39914799921231 -10.192048159717887 4.612852142014582 0.9997925679064835 2.106213190602424 0.9715802247713528 0.0891874117960497 31323971.518716507 26.61262410989078 69014.24163250392 0.03053122329864558 6.426164524394654e-11 10.192048159717887 1.1064206226959405 SIGWGEEFSLSK(ub)HPQGTEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIGWGEEFSLSKHPQGTEVK 20 1 Q8IWT0;A0A087X0V4;A8K0B5;D3DPQ2 Q8IWT0 ZBTB8OS Protein archease 1 12560500.0 1941300.0 3226000.0 7393200.0 True False 1614276.9641718979 3208620.8976891395 8939083.937705474 1.0 1.9876520379729996 5.537515640812667 20.622456694753673 -6.947334072300218 0.5873829975812329 0.9586376022011066 6.7443531032917505 0.9989751226714341 0.06237520496476516 0.08457424196917301 0.0405312645884496 0.06484237152075592 0.29715989359756323 1.1289271760487679e-07 6.947334072300218 5.785715501090644 SIHISCPK(ub)ENASSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIHISCPKENASSK 14 1 F5H0C4;Q9BRP4-2;Q9BRP4;F5H3I1;F5H103;F5H5D4 F5H0C4 PAAF1 Proteasomal ATPase-associated factor 1 1 3524900.0 1323100.0 1185500.0 1016300.0 True False 1734596.9129186256 1008628.0210428059 911143.0250379805 1.0 0.5814768915653681 0.5252765171274836 20.72616901639484 -13.999999999999998 0.28295679219159464 4.467133987826251 0.5088450747903573 0.9996117381277033 0.004173117775090158 15.560505433474628 0.16855360317298856 31.274908774511978 0.021923800301149696 1.0000000000000041e-14 13.999999999999998 -3.958288913035893 SIHISCPK(ub)ENASSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIHISCPKENASSK 14 1 F5H0C4;Q9BRP4-2;Q9BRP4;F5H3I1;F5H103;F5H5D4 F5H0C4 PAAF1 Proteasomal ATPase-associated factor 1 1 2136700.0 1323100.0 813600.0 0.0 True False 1812285.8254330663 777652.4617845867 0.0 1.0 0.42910033884901005 0.0 20.789379077917733 -8.168705027274585 0.5522508325811587 1.0244826816671038 5.819297127483319e-16 0.9909622578207751 0.03894080140785444 0.12375709861568879 0.17179821428846637 0.05222335065637315 0.07358693860646229 6.781019179249705e-09 8.168705027274585 -1.024482681667103 SIHISCPK(ub)ENASSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIHISCPKENASSK 14 1 F5H0C4;Q9BRP4-2;Q9BRP4;F5H3I1;F5H103;F5H5D4 F5H0C4 PAAF1 Proteasomal ATPase-associated factor 1 1 5154700.0 2154400.0 0.0 3000300.0 True False 2788913.269572936 0.0 2454276.185677706 1.0 0.0 0.8800116563156971 21.411271639042642 -9.09672799380484 11.788204105077153 0.9999970345580075 0.4400058281578405 0.35061534699514474 0.35926325428326245 0.0 0.0 0.34785515018398344 0.11595171672799445 8.003353620358418e-10 9.09672799380484 -0.559991206400167 SIHSK(ub)MNTLANR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIHSKMNTLANR 12 1 K7EJC8;E9PCW1;G5E9T8;O95249-2;O95249 K7EJC8 GOSR1 Golgi SNAP receptor complex member 1 1 4018190.0 983580.0 2526700.0 507910.0 True False 817890.3499820714 2513088.165589319 614111.6326894974 1.0 3.0726467987358053 0.7508483658022852 19.641547916454012 -6.671248767366984 1.9325964984820836 2.3214766473186645 0.7600804942087925 0.2848295505447397 0.8801498909015252 0.4581962601724185 3.3003672031111644 0.3664572174991097 0.9776149165474698 2.131823437759038e-07 6.671248767366984 -1.5613961531098721 SIIGMGTGAGAYILTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIIGMGTGAGAYILTR 16 0 Q92597;Q92597-3;Q92597-2;E5RIR1;E5RGM5;E5RIV1;E5RIM2;E5RG99 Q92597 NDRG1 Protein NDRG1 0 10579900.0 2325300.0 3358300.0 4896300.0 False True 3048490.8182372283 2857254.730550869 4389677.844626061 1.0 0.9372686030273365 1.4399511451257596 21.539663770065623 -6.875630163598221 1.1039332075725103 0.9629765863201637 1.4727132869845203 0.9699839369294312 0.03874803264638051 0.13156870027337217 0.29630704450038103 0.02713715410818531 0.06495236757802059 1.3315878886179237e-07 6.875630163598221 0.5097367006643566 SIIGMGTGAGAYILTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIIGMGTGAGAYILTR 16 0 Q92597;Q92597-3;Q92597-2;E5RIR1;E5RGM5;E5RIV1;E5RIM2;E5RG99 Q92597 NDRG1 Protein NDRG1 0 17070700.0 9147100.0 2320300.0 5603300.0 False True 8856730.317369392 3246807.8902046527 4135627.6346032056 1.0 0.3665921591670427 0.4669474497256185 23.078342759578852 -10.53690193238897 6.453340609835883 1.0005988394937604 0.4167698044463306 0.9782768112640835 0.04096987580954284 0.00035332362317367315 2.535482706373353e-05 0.03970648410606443 0.013222970558878798 2.9046784830151885e-11 10.53690193238897 -0.5838290350474298 SIIGMGTGAGAYILTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIIGMGTGAGAYILTR 16 0 Q92597;Q92597-3;Q92597-2;E5RIR1;E5RGM5;E5RIV1;E5RIM2;E5RG99 Q92597 NDRG1 Protein NDRG1 0 14017800.0 2325300.0 3368600.0 8323900.0 False True 3185026.2488697045 3219764.113529452 6357966.256101708 1.0 1.0109066180136115 1.9962052929259249 21.602873831588514 -6.909321246902749 0.9003615307407069 0.9688317407263977 2.12169917860252 0.9906619428808534 0.04513429765639831 0.10486975617909886 0.14122315445373232 0.036827983445058304 0.10118793641292242 1.2321930449094668e-07 6.909321246902749 1.1528674378761221 SIIGVIPYFPYSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIIGVIPYFPYSK 13 0 O60256-4;O60256-2;O60256;E7EPA1;O60256-3;C9JDU5;C9JJS3;C9K0K7;C9JDH0;E7EW35 O60256-4 PRPSAP2 Phosphoribosyl pyrophosphate synthase-associated protein 2 0 17871400.0 3885000.0 4693300.0 9293100.0 False True 5093272.622393518 3993077.934340113 8331539.15770979 1.0 0.7839906147540199 1.635792892977814 22.280161510288032 -6.8394823691097715 1.2848311688328413 0.88508078244784 1.6635176689518685 0.9235563662099647 0.09996269315012866 0.16940320684764637 0.543451075335456 0.06101298956164198 0.14054051545518945 1.4471636018605012e-07 6.8394823691097715 0.7784368865040284 SIIGVIPYFPYSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIIGVIPYFPYSK 13 0 O60256-4;O60256-2;O60256;E7EPA1;O60256-3;C9JDU5;C9JJS3;C9K0K7;C9JDH0;E7EW35 O60256-4 PRPSAP2 Phosphoribosyl pyrophosphate synthase-associated protein 2 0 13736600.0 5538700.0 2622700.0 5575200.0 False True 5362877.000231101 3669957.787199823 4114887.867585133 1.0 0.684326302289177 0.7672911139688289 22.3545757342666 -9.886173053226276 6.2732466240741465 1.0000000282320571 0.7258087081289574 0.9357460506290137 0.033870242537038873 1.337097913465462e-08 2.3369694672501662e-09 0.0327947247401674 0.010931573773138916 1.2996516029542767e-10 9.886173053226276 -0.27419132010309977 SIIGVIPYFPYSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIIGVIPYFPYSK 13 0 O60256-4;O60256-2;O60256;E7EPA1;O60256-3;C9JDU5;C9JJS3;C9K0K7;C9JDH0;E7EW35 O60256-4 PRPSAP2 Phosphoribosyl pyrophosphate synthase-associated protein 2 0 21469800.0 3885000.0 6127800.0 11457000.0 False True 5321389.488177361 5857053.534075209 8751092.564321684 1.0 1.1006624392159123 1.6445126942435173 22.343371571810923 -6.938093330472214 0.6770722171093556 0.9936473150375248 1.7832943613231542 0.9979033150484331 0.012962956155527849 0.08864735441893953 0.05865278401326269 0.012443118112170401 0.04721481939523892 1.1532054057869842e-07 6.938093330472214 0.7896470462856294 SIIGVIPYFPYSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIIGVIPYFPYSK 13 0 O60256-4;O60256-2;O60256;E7EPA1;O60256-3;C9JDU5;C9JJS3;C9K0K7;C9JDH0;E7EW35 O60256-4 PRPSAP2 Phosphoribosyl pyrophosphate synthase-associated protein 2 0 11087100.0 5538700.0 2353900.0 3194500.0 False True 4605674.456013437 2341219.0734874345 3862455.1803008365 1.0 0.508333599312605 0.8386296550460247 22.134981009700876 -9.940251361931416 5.509922925802424 1.0000004729054368 0.6734816271785447 0.565785339748341 0.13484280010284308 7.833732718756206e-07 1.5059421436799374e-07 0.13056116946996038 0.043520326595796396 1.1474892828485522e-10 9.940251361931416 -0.32651884572689216 SIILEGFK(ub)SYAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIILEGFKSYAQR 13 1 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 1 7676500.0 1851000.0 3804400.0 2021100.0 True False 2426678.9251095005 3236798.3494350538 1811975.9597601735 1.0 1.3338387357070725 0.746689618066556 21.210551806863535 -6.75249042897218 1.6408524508871438 1.1957120830190904 0.7453129481482386 0.6595433852445147 0.14030106751173382 0.2957130677355222 1.5672482862484391 0.06752744098831079 0.16349756562782589 1.7681111831265983e-07 6.75249042897218 -0.4503991348708518 SIILEGFK(ub)SYAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIILEGFKSYAQR 13 1 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 1 10533500.0 2411000.0 4818900.0 3303600.0 True False 2334464.124714677 6743111.9002315225 2438288.054124379 1.0 2.888505258591489 1.0444744163384354 21.154659987206518 -6.640619971035842 2.042068372259995 2.234381726437441 1.0521263185580116 0.1570476843681612 0.8079076812096022 0.5318043682742224 4.239116817841568 0.3220852212005418 0.8947050391699705 2.2875996896953496e-07 6.640619971035842 -1.1822554078794292 SIILEGFK(ub)SYAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIILEGFKSYAQR 13 1 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 1 9696500.0 1851000.0 3805900.0 4039600.0 True False 2535364.721394158 3637742.753571728 3085529.6781735118 1.0 1.4348005724286441 1.216996376157205 21.273761868386426 -10.126815160820216 4.361829413240949 0.9999505675942758 1.3258984743154454 0.7490704698101208 0.08891819085670413 62059073.73441215 3.384831564404957 31556.35861218333 0.030439061804638044 7.467665205446744e-11 10.126815160820216 0.3259479067211696 SIILEGFK(ub)SYAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIILEGFKSYAQR 13 1 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 1 9933600.0 2411000.0 6102800.0 1419800.0 True False 2004853.3254100054 6069923.005089044 1716673.6155865183 1.0 3.0276145033441315 0.8562589561186216 20.935065262640794 -6.661627659286029 1.9674474445768722 2.303453643541097 0.8653645579130832 0.24234149235130276 0.8629891525883641 0.4806439134443256 3.578341605804578 0.3541973818647416 0.9566425543935343 2.1795776240855605e-07 6.661627659286029 -1.4380890856280137 SIILEGFK(ub)SYAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIILEGFKSYAQR 13 1 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 1 21405000.0 6409800.0 8121400.0 6873800.0 True False 8297612.45604744 7669436.950715642 5622838.931144018 1.0 0.924294427022321 0.6776454023284731 22.984264846346345 -6.94958335358909 0.5634073308132136 1.0031701492823946 0.5869129478240791 0.9991681195777362 0.003969583103061298 0.08365364985559916 0.03665931613415765 0.0042378652292563435 0.020518706366602905 1.1230953947128016e-07 6.94958335358909 -0.41625720145831546 SIILPK(ub)SLISVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIILPKSLISVVR 13 1 A0A2R8YFL3;A0A2R8Y7R1;A0A2R8Y4U4;P15260 A0A2R8YFL3 IFNGR1 Interferon gamma receptor 1 1 4287020.0 977570.0 2607400.0 702050.0 True False 1281603.7368013451 2218386.0835655946 629408.600539127 1.0 1.7309453927641405 0.4911101477513002 20.289518828688514 -6.74692716866754 1.661020159389636 1.4313767461271458 0.4891803727533106 0.6357477934079059 0.30711352453686025 0.305423205522694 1.6569098801914224 0.14611418477003255 0.3559051082152058 1.790906164426958e-07 6.74692716866754 -0.9421963733738352 SIILPK(ub)SLISVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIILPKSLISVVR 13 1 A0A2R8YFL3;A0A2R8Y7R1;A0A2R8Y4U4;P15260 A0A2R8YFL3 IFNGR1 Interferon gamma receptor 1 1 6112500.0 1917700.0 1729100.0 2465700.0 True False 1856823.6631959104 2419538.6471373793 1819859.2005855674 1.0 1.303052462705554 0.9800926370430239 20.824405382813875 -6.6605489032206755 1.9713431853865095 1.1949889730852488 0.9814494676052454 0.23776999878791072 0.12901713779378945 0.4831468655528924 3.6101270085925954 0.05286971652137831 0.14299442125377484 2.1849982666336286e-07 6.6605489032206755 -0.21353950548000333 SIILPK(ub)SLISVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIILPKSLISVVR 13 1 A0A2R8YFL3;A0A2R8Y7R1;A0A2R8Y4U4;P15260 A0A2R8YFL3 IFNGR1 Interferon gamma receptor 1 1 5725370.0 977570.0 2740200.0 2007600.0 True False 1339004.0468359168 2619128.9033703594 1533446.2278198688 1.0 1.9560276233364593 1.1452140353447187 20.352728890211406 -10.156496775205582 4.2736220358570725 0.9998658653481209 1.5506208293711126 0.3807652419971793 0.3310132613227538 47454056.99112752 37592460.00624717 53886.57750614954 0.11331464184366999 6.974341755648159e-11 10.156496775205582 0.5507549640229916 SIISMFDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIISMFDR 8 0 O75340;O75340-2 O75340 PDCD6 Programmed cell death protein 6 0 5133280.0 861080.0 1670800.0 2601400.0 False True 1128884.218710582 1421523.1527273897 2332232.082390833 1.0 1.2592284746003992 2.06596216311246 20.106466096482336 -6.950623559775989 0.5519573851707862 0.9889703821002811 2.37424675884563 0.9992493008010578 0.012436580028165395 0.08323635024078399 0.03493383257708688 0.013464672403789598 0.0669504517641313 1.1204086168066898e-07 6.950623559775989 1.385276376745349 up SIISMFDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIISMFDR 8 0 O75340;O75340-2 O75340 PDCD6 Programmed cell death protein 6 0 5342700.0 2120700.0 1023900.0 2198100.0 False True 2053379.5393124884 1432748.6095679617 1622351.668413489 1.0 0.6977514785443288 0.7900885527264404 20.969568883997365 -10.376213656013968 8.337217308756559 1.000001613367598 0.7439200156353847 0.9111509935041534 0.03769645268128195 1.1304528847607717e-06 8.457910816833255e-08 0.036499663118339236 0.012166477787141737 4.2051969813232996e-11 10.376213656013968 -0.2560815977322133 SIISMFDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIISMFDR 8 0 O75340;O75340-2 O75340 PDCD6 Programmed cell death protein 6 0 5535180.0 861080.0 1877700.0 2796400.0 False True 1179444.5458120366 1794737.0052764493 2135947.9136658073 1.0 1.521679854851327 1.810977821085456 20.169676158005228 -9.946794371657418 0.12857540253875693 8.101048055565897e-15 2.3678239646076693 0.9998371545710069 0.0042823687148221415 1.5228607671534815 0.05938022474369597 0.8195642116392083 0.3096136001352989 1.1303309734367353e-10 9.946794371657418 2.3678239646076613 SIISMFDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIISMFDR 8 0 O75340;O75340-2 O75340 PDCD6 Programmed cell death protein 6 0 3849060.0 2120700.0 1127700.0 600660.0 False True 1763456.0129394413 1121624.8562690772 726255.2288619505 1.0 0.636037898330949 0.41183631660388387 20.74997415943164 -8.86501733260325 0.14437348529538113 1.4913746760326374 1.1343717158651684e-09 0.9998786467512912 0.002669907973075813 0.36858280941980437 0.04358872255209504 0.24535051677223463 0.16816266808706581 1.3645286774439645e-09 8.86501733260325 -1.4913746748982657 SIITYVVTYYHYFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIITYVVTYYHYFSK 15 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 39622700.0 4462700.0 15979000.0 19181000.0 False True 6770242.167071728 13127422.605503157 15389866.94266904 1.0 1.9389886331320174 2.2731634353524877 22.69077600829209 -10.279564508103384 0.23420077050670157 1.0889086783910436e-14 2.4804549854815523 0.9992039712836379 0.01520625445648118 1.8481126860875694 0.11259003585062216 1.2957335287536875 0.16463010092344924 5.2533397862344004e-11 10.279564508103384 2.480454985481541 SIIVSAGPWVAFEQSNFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIIVSAGPWVAFEQSNFR 18 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 10169800.0 7167700.0 1560400.0 1441700.0 False True 6940165.286900617 2183475.8573785014 1064075.5199270854 1.0 0.31461438843535267 0.1533213512847454 22.72653859174619 -13.999999999999998 0.20324420250088507 4.857902721271333 0.05185617615308487 0.9994873562301969 0.00831096175550717 12.59693264551972 0.1429345560529495 19.346073116436763 0.10027314110060656 1.0000000000000041e-14 13.999999999999998 -4.806046545118248 SIIVSAGPWVAFEQSNFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIIVSAGPWVAFEQSNFR 18 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 62665000.0 19085000.0 24619000.0 18961000.0 False True 28953340.300393082 20225547.100875035 15213350.039098486 1.0 0.6985566049040789 0.5254436925501111 24.787226463438806 -11.173771755343253 0.08819162714255295 2.0355689358942364 1.8017976978506036e-12 0.9999256695676659 0.0016905289979692653 3.708422433095209 0.05588124600457547 1.1132658281396053 0.34548665302636594 6.702367616404681e-12 11.173771755343253 -2.0355689358924347 SIIVSAGPWVAFEQSNFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIIVSAGPWVAFEQSNFR 18 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 12622700.0 7167700.0 2546100.0 2908900.0 False True 5960260.13294952 2532383.653938722 3517137.540766037 1.0 0.4248780418054565 0.5900979927574959 22.506943867180468 -10.786282581509042 10.675319445269945 1.0025758174905037 0.50748801728157 0.9221672564261287 0.06745076252669335 0.004140118980695318 8.288417240870179e-05 0.06538834152674278 0.02176963999623956 1.63575184375749e-11 10.786282581509042 -0.4950878002089337 SIIVSAGPWVAFEQSNFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIIVSAGPWVAFEQSNFR 18 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 51828000.0 19085000.0 15943000.0 16800000.0 False True 24705908.721592817 15055758.034976678 13742572.382556884 1.0 0.6093990795739497 0.5562463837060143 24.558352785531255 -13.999999999999998 0.28105190500105043 4.2018818004754355 0.5404103085154517 0.9996075074489861 0.003919741531856273 15.455363073263422 0.16795349678520602 28.461863459845173 0.020921215344337805 1.0000000000000041e-14 13.999999999999998 -3.6614714919599836 SIK(ub)YDEQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIKYDEQIR 9 1 Q9UPU5 Q9UPU5 USP24 Ubiquitin carboxyl-terminal hydrolase 24 1 2082880.0 550110.0 897910.0 634860.0 True False 721199.5372728185 763945.3280257669 569170.777207137 1.0 1.059270407902076 0.7892001419737857 19.460038945563106 -6.84918483698024 1.239026898423718 1.031607945742532 0.7785728855678223 0.9391101653651115 0.02859840750743632 0.15835558375331535 0.46822915914675456 0.018064964189621904 0.0417820107097792 1.4151913422621523e-07 6.84918483698024 -0.25303506017470967 SILCCLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SILCCLR 7 0 Q15185-4;Q15185;A0A087WYT3;Q15185-3 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 78743000.0 16736000.0 29891000.0 32116000.0 False True 21941058.071654554 25431379.314205397 28792944.39842548 1.0 1.1590771616916669 1.3122860485758803 24.3871297632399 -6.971583780210284 0.21705323197390664 0.9266643921087525 1.5490102693203538 0.9999922383531283 0.000355158390620221 0.07579207972704793 0.007162258405595168 0.004341117364731304 0.015626993846091102 1.0676188171910656e-07 6.971583780210284 0.6223458772116013 SILCCLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SILCCLR 7 0 Q15185-4;Q15185;A0A087WYT3;Q15185-3 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 310020000.0 46783000.0 215930000.0 47307000.0 False True 70973231.29543032 177395604.43120965 37956750.714605354 1.0 2.4994720008278875 0.5348037565967387 26.080771655598944 -6.702749659203051 1.8211170197805542 1.9286376224870825 0.5403801893753558 0.4304724928976148 0.6326414053838092 0.3899094288851767 2.5158891199888886 0.2769449421224194 0.7098077889295437 1.9826695686517058e-07 6.702749659203051 -1.3882574331117268 SILCCLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SILCCLR 7 0 Q15185-4;Q15185;A0A087WYT3;Q15185-3 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 94047000.0 16736000.0 41729000.0 35582000.0 False True 22923751.473394167 39885274.8006503 27178264.434292957 1.0 1.7399104525689029 1.1855940972766468 24.450339824762793 -10.053359363088507 5.449904407726165 0.9999967919058818 1.4627522749231214 0.4816569064425329 0.2262987044254409 8.821214522554128e-06 1.5319185731781283e-06 0.21911429626294354 0.07303759279216086 8.843835113820591e-11 10.053359363088507 0.4627554830172397 SILCCLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SILCCLR 7 0 Q15185-4;Q15185;A0A087WYT3;Q15185-3 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 162533000.0 46783000.0 52071000.0 63679000.0 False True 60561515.73079776 49173203.07591234 52090075.40171664 1.0 0.8119546296445477 0.8601184229480393 25.851897977691394 -10.127701613793475 4.992461470932241 1.0000072415383334 0.836036526295833 0.9392180172872482 0.01966278628000201 1.5849455331966005e-06 2.769021271977399e-07 0.019039251575513887 0.0063461369833118925 7.452438249972253e-11 10.127701613793475 -0.1639707152425004 SILDWTSFNQER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SILDWTSFNQER 12 0 A0A3B3IUC4;P06280 A0A3B3IUC4 GLA Alpha-galactosidase A 0 2195320.0 0.0 865820.0 1329500.0 False True 0.0 736643.0309399262 1191936.0934645229 0.0 SILEIMHK(ub)EAQDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SILEIMHKEAQDIK 14 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 5029300.0 2576600.0 2452700.0 0.0 True False 3377947.5518298955 2086766.7205497206 0.0 1.0 0.6177617291361677 0.0 21.687715497433178 -7.608589820112238 0.6752550703590847 0.9967568309709453 4.203008089958503e-21 0.9871469174743606 0.04670963746236408 0.12119460335384827 0.14695871719890383 0.04235724095769798 0.07721021294571055 2.4626924553219732e-08 7.608589820112238 -0.9967568309709453 down SILEIMHK(ub)EAQDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SILEIMHKEAQDIK 14 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 10600500.0 2791800.0 2836100.0 4972600.0 True False 2703175.8371540606 3968569.5200661165 3670126.8851976283 1.0 1.4681137148089778 1.3577092672822892 21.366223929195034 -10.100165143567475 4.905079598502712 0.9999857189291609 1.4129114910419163 0.949109491898867 0.04507242698079753 7.850037321266358e-06 1.440037929264465e-06 0.04364287135613078 0.014547063253107792 7.940262431809102e-11 10.100165143567475 0.4129257721127554 SILEIMHK(ub)EAQDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SILEIMHKEAQDIK 14 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 29581400.0 5303900.0 9191500.0 15086000.0 True False 8046404.067029331 7551205.011482716 12104245.487571316 1.0 0.9384570981743602 1.5043049524655687 22.93991275705931 -6.879958001786626 1.0800861681647658 0.9618829181321197 1.5443655440397335 0.9736492582869549 0.041148102195860195 0.12766485722240933 0.27253982624087875 0.02934921369172843 0.07096322364011405 1.3183842260267166e-07 6.879958001786626 0.5824826259076138 SILEIMHK(ub)EAQDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SILEIMHKEAQDIK 14 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 9903500.0 2576600.0 4322200.0 3004700.0 True False 3529238.649996858 4131230.912395946 2295051.7437389717 1.0 1.1705728408022575 0.6502965572308392 21.75092555895607 -6.818394902641592 1.378824343299026 1.0920920976549777 0.6393276454372848 0.8806316645513316 0.07482007328430439 0.19558755492085106 0.7310842003044478 0.042646317015008955 0.09833653201845882 1.519165528942866e-07 6.818394902641592 -0.4527644522176929 SILEIMHK(ub)EAQDIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SILEIMHKEAQDIK 14 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 9484000.0 2791800.0 5213700.0 1478500.0 True False 2321505.3977103513 5185612.763261579 1787647.5141883823 1.0 2.2337284971967035 0.7700380606271685 21.14662920462931 -6.683280612223026 1.890672796600103 1.7783121129906485 0.7755208452162364 0.33898865993594085 0.522516976884718 0.4312852738339218 2.983580801663173 0.22155352383408364 0.5817938964362199 2.0735732793097787e-07 6.683280612223026 -1.0027912677744122 SILEIMHK(ub)EAQDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SILEIMHKEAQDIK 14 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 26353600.0 5303900.0 7636700.0 13413000.0 True False 6866003.105499401 7211710.9318011785 10971971.629002105 1.0 1.050350665589545 1.598014370283926 22.71103907915176 -6.924860232809278 0.7878316200541783 0.9898984407212095 1.6970233951787561 0.9954281910828664 0.018311543966030627 0.09539560868989795 0.09140571164170802 0.016198100959731798 0.051025878009781096 1.1888847797307133e-07 6.924860232809278 0.7071249544575466 SILEYLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SILEYLR 7 0 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 0 4472960.0 998060.0 1634600.0 1840300.0 False True 1308466.3252267872 1390724.0516208962 1649883.409404108 1.0 1.0628657572672737 1.260929209712864 20.319445364895852 -6.950345550907729 0.5550465238953274 0.9973392579006192 1.335841188315472 0.9992280559254947 0.0030892336215469643 0.08334747212878611 0.03539178525984449 0.003331652993873779 0.0164472659178633 1.1211260637515576e-07 6.950345550907729 0.33850193041485277 SILEYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SILEYLR 7 0 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 0 5056960.0 998060.0 1700700.0 2358200.0 False True 1367069.7535573465 1625557.4505371777 1801241.728653524 1.0 1.1890815712272198 1.3175931396085596 20.382655426418744 SILFVPTSAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SILFVPTSAPR 11 0 P14625 P14625 HSP90B1 Endoplasmin 0 86256000.0 18289000.0 35813000.0 32154000.0 False True 23977056.110927936 30469839.99798064 28827012.52294718 1.0 1.2707915374187038 1.2022748910283776 24.515151200574813 -10.087834020115507 4.482824040793831 0.9999819091821267 1.2365332141834553 0.9407942525789237 0.02797180380762225 5.3866442299171805e-06 1.0960815981158842e-06 0.027085787581086235 0.009027860852026934 8.168945147461737e-11 10.087834020115507 0.2365513050013286 SILFVPTSAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SILFVPTSAPR 11 0 P14625 P14625 HSP90B1 Endoplasmin 0 81232000.0 36801000.0 18934000.0 25497000.0 False True 35632772.39884891 26494444.93950561 18818570.806395832 1.0 0.7435414972190457 0.5281253615563113 25.086701400572668 -6.973138220727701 0.1669923515195367 1.1982117835688195 0.06770255564737228 0.999997655873802 0.00029526052035604573 0.0752969007087142 0.005192276232350282 0.00933417250323783 0.025213859849681598 1.0638043926494896e-07 6.973138220727701 -1.1305092279214473 SILFVPTSAPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SILFVPTSAPR 11 0 P14625 P14625 HSP90B1 Endoplasmin 0 192803000.0 32297000.0 133370000.0 27136000.0 False True 48996910.22697378 109569081.47543372 21772557.70586868 1.0 2.2362447135516264 0.4443659325661407 25.546187439137977 -6.721086130342937 1.7554813686126847 1.751240297091383 0.4470002467398327 0.5176216226958261 0.520147244824869 0.35320342927995074 2.1278249498341313 0.2352164917296861 0.5897118055134284 1.9007012908170943e-07 6.721086130342937 -1.3042400503515503 SILFVPTSAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SILFVPTSAPR 11 0 P14625 P14625 HSP90B1 Endoplasmin 0 101417000.0 18289000.0 39301000.0 43827000.0 False True 25050937.541641116 37564551.86897254 33475965.245398123 1.0 1.499526786433864 1.3363158640171626 24.578361262097705 -10.096615435726337 4.642645462526736 0.9999750302861187 1.4179213252330638 0.8973556089169058 0.06663058010089114 46365099.467332125 0.3041932598678523 13248.626775819836 0.022809419832113507 8.005428154782406e-11 10.096615435726337 0.41794629494694513 SILFVPTSAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SILFVPTSAPR 11 0 P14625 P14625 HSP90B1 Endoplasmin 0 65368000.0 36801000.0 16671000.0 11896000.0 False True 30601662.0607273 16581190.014065577 14383398.599110581 1.0 0.5418395243095334 0.47002017637367294 24.867106676006944 -13.999999999999998 0.26084187811009213 4.368724715522613 0.4439815702261034 0.9995640565543221 0.004901301744879447 14.454424124149188 0.16162087076066095 25.679486137210734 0.03125967065472446 1.0000000000000041e-14 13.999999999999998 -3.9247431452965094 SILFVPTSAPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SILFVPTSAPR 11 0 P14625 P14625 HSP90B1 Endoplasmin 0 90163000.0 32297000.0 32865000.0 25001000.0 False True 41809103.16904808 31036033.859343164 20451074.531922877 1.0 0.742327184916026 0.4891536287978337 25.317313761230427 -6.9713417982476775 0.22382970589574303 1.1112508231893592 0.1130489516774226 0.9999910406996613 0.0006242215745588208 0.07586967280170495 0.00745290724728323 0.006811534112405963 0.02545651842603312 1.0682138431321132e-07 6.9713417982476775 -0.9982018715119366 down SILK(ub)IDDVVNTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SILKIDDVVNTR 12 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 1 10566000.0 3198700.0 5480700.0 1886600.0 True False 4193526.676254861 4663000.923601276 1691392.72954507 1.0 1.1119521308889566 0.40333420057210956 21.99973260282455 -6.866484467916957 1.1524598352306463 1.062157053918991 0.3645029156483287 0.9610506432995171 0.061384518332244634 0.14027410573475932 0.3504034764030543 0.04141756488761466 0.09750729901151063 1.3599267987591637e-07 6.866484467916957 -0.6976541382706624 down SILK(ub)IDDVVNTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SILKIDDVVNTR 12 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 1 20486200.0 7691000.0 9465300.0 3329900.0 True False 7446853.414840553 13244843.650887411 2457699.295141293 1.0 1.778582565421828 0.3300319152574478 22.828199528893453 -6.760673986305972 1.6097109912708254 1.4518433441706338 0.3245081831577045 0.693866264198742 0.3275067271451719 0.2817494442352913 1.4389927684465467 0.1605114786395555 0.385512306500407 1.7351060084397307e-07 6.760673986305972 -1.1273351610129292 SILK(ub)IDDVVNTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SILKIDDVVNTR 12 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 1 8718400.0 3198700.0 3956800.0 1562900.0 True False 4381345.831617224 3781975.4926121626 1193775.20893588 1.0 0.8631994911974743 0.2724676970991899 22.062942664347442 -6.94312117214125 0.6298691271940784 1.006443921379995 0.0973938183952159 0.9985446706334822 0.012043455971828758 0.08637144674878205 0.04834117902067961 0.012021741961579393 0.05018614783605471 1.139931691796643e-07 6.94312117214125 -0.9090501029847791 down SILK(ub)IDDVVNTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SILKIDDVVNTR 12 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 1 18536500.0 7691000.0 9309600.0 1535900.0 True False 6395407.269070238 9259447.336989088 1857049.5888007663 1.0 1.4478276280808655 0.290372373590954 22.60860480432773 -6.801784445626042 1.4484948294191777 1.2465282394541997 0.2736586118278274 0.8373694945152039 0.19217702140157555 0.2182150292676998 0.9036853859228972 0.10436236301145464 0.24246259094029024 1.578394483461797e-07 6.801784445626042 -0.9728696276263722 down SILK(ub)IDDVVNTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SILKIDDVVNTR 12 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 1 38941400.0 10606300.0 19548500.0 8786600.0 True False 13730064.43142936 18460608.79048745 7187528.9581294255 1.0 1.3445391230815673 0.5234883633667823 23.71083505988486 -6.792723506899258 1.4855353800170787 1.1918824561542964 0.5141010765970562 0.8100013090070453 0.1467343386218352 0.2313133836690521 1.0083741466496094 0.07773782846655614 0.1816409069466497 1.6116713774216315e-07 6.792723506899258 -0.6777813795572403 SILLK(ub)NGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SILLKNGR 8 1 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 1 4281040.0 1624800.0 2123800.0 532440.0 True False 2130128.53458558 1806937.3185075622 477348.21632512356 1.0 0.8482761904596074 0.22409362091287716 21.02250905640175 -6.9442297389294865 0.6189636736112089 1.0068366071542627 0.032523868047673675 0.9986670727127891 0.012258605330976951 0.08588889025679253 0.04621276421041663 0.012357048375962937 0.052804211218756475 1.1370256476038954e-07 6.9442297389294865 -0.974312739106589 down SILLK(ub)NGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SILLKNGR 8 1 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 1 7473300.0 3462600.0 2829000.0 1181700.0 True False 3352681.65833141 3958634.453040109 872177.319759893 1.0 1.1807367523853352 0.2601431954007722 21.676884073109004 -6.85572890554988 1.207055269641285 1.0971525450230741 0.21904883945464934 0.9482480953114214 0.09060184140103113 0.15126041549175975 0.4212157775360724 0.05863553238313399 0.13628654343369453 1.394026708030727e-07 6.85572890554988 -0.8781037055684248 down SILLK(ub)NGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SILLKNGR 8 1 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 1 10632200.0 6849300.0 1457200.0 2325700.0 True False 10390888.85090292 1197151.2748444332 1866024.3756094773 1.0 0.11521163319347856 0.17958274815415126 23.30881573384746 -10.291260559902986 6.332078193396363 1.0000277302130045 0.1473971906738146 0.9957430640212834 0.026279397637948503 1.0287986930536688e-05 1.1515188911394836e-06 0.025445741037125536 0.00848163911667793 5.113749382887315e-11 10.291260559902986 -0.8526305395391899 SILLK(ub)NGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SILLKNGR 8 1 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 1 4458970.0 1624800.0 2067900.0 766270.0 True False 2225532.4685690003 1976533.3403691587 585292.8078260265 1.0 0.8881170543605027 0.26299001074667094 21.08571911792464 -6.937361563459382 0.683670439791047 1.0074395925903905 0.10674080789644619 0.9977974627363504 0.015219391607333144 0.08899127184910952 0.060247666906566015 0.014533959163563082 0.05445835520089819 1.1551501438804657e-07 6.937361563459382 -0.9006987846939443 down SILLK(ub)NGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SILLKNGR 8 1 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 1 8564420.0 3462600.0 4511600.0 590220.0 True False 2879305.319188998 4487295.11531752 713632.273131057 1.0 1.5584644967701575 0.24784876698385805 21.45728934854328 -6.790903710560234 1.4925396751357736 1.3117546409554548 0.233523941384951 0.8043062200467651 0.23755455052557045 0.23399902532797612 1.0297441507851968 0.12526768672482658 0.29311331656214806 1.6184388294309106e-07 6.790903710560234 -1.0782306995705038 down SILLSVPLLVVDNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SILLSVPLLVVDNK 14 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 61665000.0 15901000.0 25095000.0 20669000.0 False True 24122979.518813223 20616601.181870073 16583763.09045548 1.0 0.8546457192732528 0.6874674447873241 24.52390477507893 -6.969295000260837 0.2745046515793335 1.0393541512373197 0.49770263807960535 0.9999763468931723 0.0006210086195712808 0.07653214436517193 0.009846137894639645 0.0031890793724555556 0.015454255787579722 1.0732601385654547e-07 6.969295000260837 -0.5416515131577143 SILLSVPLLVVDNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SILLSVPLLVVDNK 14 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 15901000.0 15901000.0 0.0 0.0 False True 20584157.95556968 0.0 0.0 1.0 0.0 0.0 24.29503109717138 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 SILPTAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SILPTAPR 8 0 E7EX17;P23588-2;P23588;F8VP89;F8VX11;F8W0K0;F8VSC7;F8VRU1;F8VYE9 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 7383300.0 1024200.0 4113000.0 2246100.0 False True 1342736.1183669074 3499356.432348426 2013695.1181125762 1.0 2.6061386034692293 1.4996953538136129 20.35674437585449 -10.497985291685893 5.452958637883648 0.9980728185739856 2.0529169786409245 0.5469883508161778 0.4517035651671972 0.01059629461960297 0.0009755250119273394 0.43790212339580686 0.14578669877625441 3.176981664125882e-11 10.497985291685893 1.054844160066939 SILPTAPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SILPTAPR 8 0 E7EX17;P23588-2;P23588;F8VP89;F8VX11;F8W0K0;F8VSC7;F8VRU1;F8VYE9 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 22186400.0 2827800.0 16823000.0 2535600.0 False True 4289979.339871703 13820804.211301068 2034437.5486070386 1.0 3.2216481983604135 0.47423015064400775 22.03253926918503 -6.691502244491438 1.8608774914223365 2.3907827995768507 0.48344188959879286 0.37772144621703474 0.939300032272352 0.41334839617559593 2.776279078664414 0.4036132200973235 1.049128620349484 2.0346876802877534e-07 6.691502244491438 -1.9073409099780578 SILPTAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SILPTAPR 8 0 E7EX17;P23588-2;P23588;F8VP89;F8VX11;F8W0K0;F8VSC7;F8VRU1;F8VYE9 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 7596200.0 1024200.0 3226500.0 3345500.0 False True 1402874.4179642848 3083942.5613913094 2555361.8027352896 1.0 2.198302657672258 1.821518569312414 20.41995443737738 -10.103781001551914 4.744074050578945 0.9999434351418695 2.009910613504894 0.9054729744270675 0.15382145999001726 9.203380131160257e-05 1.7386764927141728e-05 0.14894527226174026 0.04964566272977091 7.874427675034952e-11 10.103781001551914 1.0099671783630246 SILPTAPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SILPTAPR 8 0 E7EX17;P23588-2;P23588;F8VP89;F8VX11;F8W0K0;F8VSC7;F8VRU1;F8VYE9 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 7841900.0 2827800.0 3183900.0 1830200.0 False True 3660642.844271421 3006713.166126962 1497122.3794378354 1.0 0.8213620650897968 0.4089779973429252 21.80366559127748 -6.957146535165274 0.47394725951843614 1.010484706023672 0.20283701604116916 0.9996492637985078 0.004635050655250143 0.08073674223034073 0.025021184710217144 0.0057450315485370025 0.034027643544266635 1.1037061559203448e-07 6.957146535165274 -0.8076476899825027 down SILSLGLACFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SILSLGLACFK 11 0 Q96GM8 Q96GM8 TOE1 Target of EGR1 protein 1 0 7181000.0 2211500.0 2979500.0 1990000.0 False True 2899297.916196466 2534970.214000036 1784093.8894279057 1.0 0.87433933568497 0.6153537652896411 21.467272153891614 -6.95945299143582 0.44307524575053864 1.008968843665227 0.4705750458571715 0.9997493704594936 0.002535289204649094 0.0798971003209179 0.021857660116251957 0.0034280581650752745 0.021446500516169354 1.0978601175601439e-07 6.95945299143582 -0.5383937978080555 SILTISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SILTISR 7 0 P56192;H0YIP0 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 16184400.0 5430300.0 3387300.0 7366800.0 False True 7119175.8871000055 2881928.043591982 6604554.203335437 1.0 0.4048120301134932 0.9277133067189608 22.763278814391253 -10.380997636908962 8.545428825799085 1.0000017130267804 0.6662626684162315 0.3519691460005291 0.2134735522555537 6.96692340467665e-06 5.046014157774389e-07 0.20669594055108406 0.06889829272845818 4.1591287356056155e-11 10.380997636908962 -0.33373904461054893 SILTISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SILTISR 7 0 P56192;H0YIP0 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 10644300.0 2603400.0 1650600.0 6390300.0 False True 2520756.4920291095 2309693.1877652877 4716488.725109281 1.0 0.9162698559217339 1.8710608263921176 21.265425328254526 -6.885535642358529 1.0484644820172992 0.943073918587236 1.9463338747757035 0.9778823036757633 0.06420441186442184 0.12283870007271054 0.24362323702271832 0.0469123365349841 0.11521973575988012 1.30156049269446e-07 6.885535642358529 1.0032599561884674 SILTISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SILTISR 7 0 P56192;H0YIP0 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 17421300.0 5430300.0 6606200.0 5384800.0 False True 7438028.658339647 6314316.2402179735 4113021.143437155 1.0 0.8489233545958784 0.5529719408684403 22.826488875914144 -6.9604485401397485 0.429067070496365 1.0118726292715823 0.37869090204145023 0.9997864701559118 0.0027130624056320974 0.07954131074130176 0.020542292707509364 0.0038557364378425983 0.024578492305480114 1.0953463360395621e-07 6.9604485401397485 -0.6331817272301321 SILTISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SILTISR 7 0 P56192;H0YIP0 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 6428300.0 2603400.0 2234900.0 1590000.0 False True 2164842.450175198 2222860.150107085 1922461.648670631 1.0 1.0267999640930876 0.8880376715243407 21.045830603688803 -6.856637402213525 1.2025866099243714 1.0144299716691854 0.8817364289691346 0.9494218101075258 0.013516388019508196 0.15030767676736634 0.41498377168130457 0.008777286529216706 0.020417671278931012 1.3911136042909264e-07 6.856637402213525 -0.13269354270005074 SILYDER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SILYDER 7 0 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 4993080.0 349880.0 2349100.0 2294100.0 False True 458696.06824274006 1998623.4367200828 2056728.5385610864 1.0 4.357184582760407 4.4838590974638 18.807179015711032 -10.219679521298431 0.690915627823442 1.3142110890095462e-13 4.462733996352525 0.9998513704542356 0.019668077668873043 1.519442953125632 0.3456804906253956 3.0428865231499946 0.019871456904077833 6.030043966561294e-11 10.219679521298431 4.4627339963523935 SILYDER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SILYDER 7 0 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 6464410.0 1808200.0 638310.0 4017900.0 False True 1750799.6807586395 893190.511742676 2965491.4555837116 1.0 0.5101614545392466 1.6937925498699735 20.73958259535233 -6.794335234990805 1.4791609301700912 0.7277655978886305 1.707895150403234 0.8150141589555444 0.20885677124258098 0.2289456740972161 0.9894430196058339 0.11111941515080138 0.2593387082050855 1.6057013222797128e-07 6.794335234990805 0.9801295525146035 SILYDER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SILYDER 7 0 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 5046780.0 349880.0 1899700.0 2797200.0 False True 479240.0911514791 1815764.9725321808 2136558.9701423277 1.0 3.7888419730690903 4.4582225268524125 18.870389077233924 -9.635610798838378 0.3985634986441177 1.902460814951535e-18 4.5447023723904385 0.9984829047307098 0.05833103549248118 0.9640952687462766 0.16863343277393492 1.4753046584361136 0.16990059584492273 2.3141377191961881e-10 9.635610798838378 4.5447023723904385 SILYDER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SILYDER 7 0 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 0 6008400.0 2344000.0 1787600.0 1876800.0 False True 3034354.2071476784 1688118.488573309 1535241.6575942112 1.0 0.5563353429856023 0.5059533438706066 21.53295807385058 -13.999999999999998 0.30707260340611986 5.2159724803517085 0.4944422317083272 0.9996655430117547 0.004059523582405653 17.064028594431257 0.17621275302284048 45.89189866340935 0.017671365133115225 1.0000000000000041e-14 13.999999999999998 -4.721530248643381 SIMSFFHPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIMSFFHPK 9 0 P18858;M0R0Q7;F5GZ28;P18858-2;B4E135;M0R1S4;M0QY71;M0R1G7 P18858 LIG1 DNA ligase 1;DNA ligase 0 18187210.0 4436560.0 3114650.0 10636000.0 False True 5816373.12370815 2649956.360810611 9535488.747716183 1.0 0.45560288249203085 1.6394217745158963 22.471688391273698 -6.78165617661649 1.5293343578828602 0.692414253667431 1.6493057035675054 0.7732402283694871 0.2303872926928965 0.24800605086523525 1.1457983807455059 0.11863696471436899 0.2795581955083198 1.6532701454659293e-07 6.78165617661649 0.9568914499000744 SIMTIVGHTDVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIMTIVGHTDVVK 13 0 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 0 21391600.0 6368900.0 7359400.0 7663300.0 False True 8349689.576515333 6261406.206716515 6870375.227564267 1.0 0.7498968853078795 0.8228300183623779 22.993291131611848 -10.03056859283172 6.6897454049660885 1.0000000698918041 0.7863634518351281 0.9196165410502366 0.029774826887674716 3.1029024206504555e-08 4.495145244695294e-09 0.02882936161900883 0.009609784056014077 9.320332526088812e-11 10.03056859283172 -0.213636618056676 SIMTIVGHTDVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIMTIVGHTDVVK 13 0 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 0 20873100.0 7512100.0 1539500.0 11821500.0 False True 7273632.497415641 2154230.3783864393 8725094.512601815 1.0 0.2961698132469366 1.1995511892719195 22.794244604335486 -6.698758735765174 1.8349842253231796 0.5624337002553607 1.196832063441945 0.4118648311779721 0.2971614634710726 0.39809174366982497 2.6050643105525886 0.12922815253086803 0.33288939973696124 2.0009731644091583e-07 6.698758735765174 0.6343983631865843 SIMTIVGHTDVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIMTIVGHTDVVK 13 0 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 0 27334300.0 2871900.0 19875100.0 4587300.0 False True 4356882.2640135605 16328233.12013493 3680618.144314984 1.0 3.7476874817116035 0.8447825580956594 22.054864697170146 -6.658582333514816 1.9778601253139616 2.7706999130336625 0.8568931495526595 0.22963741523348802 1.1702976023318368 0.4878015883337648 3.666798925192953 0.47828708331032 1.2971890870758094 2.1949147979138506e-07 6.658582333514816 -1.913806763481003 SIMTIVGHTDVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIMTIVGHTDVVK 13 0 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 0 18785000.0 6368900.0 5112200.0 7303900.0 False True 8723654.44305091 4886326.100215304 5578869.248542311 1.0 0.5601237568628884 0.6395105726575778 23.05650119313474 -10.800199341633707 7.182351085221414 1.0146967051519833 0.5998171647602331 0.9713312671336969 0.03240953183355156 0.007466369731944267 0.00020770130994093977 0.030718970630436084 0.01046013142081036 1.5841658917119832e-11 10.800199341633707 -0.41487954039175023 SIMTIVGHTDVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIMTIVGHTDVVK 13 0 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 0 11191200.0 7512100.0 2098600.0 1580500.0 False True 6246643.992456445 2087294.4252605122 1910975.2425936689 1.0 0.33414653176668385 0.3059203061518146 22.574649879769762 SINGILFPGGSVDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SINGILFPGGSVDLR 15 0 Q92820 Q92820 GGH Gamma-glutamyl hydrolase 0 8615800.0 3297200.0 2756700.0 2561900.0 False True 4322661.130130222 2345411.1055324357 2296819.163480079 1.0 0.5425850037571136 0.5313437936345674 22.043488311631794 SINGILFPGGSVDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SINGILFPGGSVDLR 15 0 Q92820 Q92820 GGH Gamma-glutamyl hydrolase 0 13389400.0 4509100.0 4597200.0 4283100.0 False True 4365961.088656557 6432885.9340813 3161227.6197542506 1.0 1.4734180638473702 0.7240622524024801 22.05786784178472 -6.735977967755418 1.7015821802219053 1.2829876890417815 0.7240103108473782 0.5866961563430986 0.19893757603698853 0.3251363072185972 1.8468341922869191 0.09255418538333604 0.22811605324876896 1.8366315153549832e-07 6.735977967755418 -0.5589773781944033 SINGILFPGGSVDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SINGILFPGGSVDLR 15 0 Q92820 Q92820 GGH Gamma-glutamyl hydrolase 0 11384500.0 3297200.0 3459400.0 4627900.0 False True 4516263.9434796395 3306552.269294 3534885.334592336 1.0 0.7321432738819081 0.7827012280129974 22.106698373154686 -10.581266206351696 6.405650104300232 1.0005041836904658 0.7574222509474539 0.9684488604619124 0.020640198343367572 0.00014891739895935973 9.734618902699376e-06 0.020025216034057703 0.0066615953705233795 2.622610487987835e-11 10.581266206351696 -0.24308193274301193 SINGILFPGGSVDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SINGILFPGGSVDLR 15 0 Q92820 Q92820 GGH Gamma-glutamyl hydrolase 0 10435500.0 0.0 5840700.0 4594800.0 False True 0.0 5515659.910612074 3758593.5466293055 0.0 SINHASLISALSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SINHASLISALSR 13 0 Q96QU8;Q96QU8-2 Q96QU8 XPO6 Exportin-6 0 2807840.0 962880.0 1102800.0 742160.0 False True 1318882.7568535937 1054074.649528076 566877.0932649891 1.0 0.7992178562124355 0.42981613818150544 20.33088489007446 -6.961644267793137 0.411607977596856 1.0178810087952492 0.19740821154598903 0.9998263981089506 0.003111397412010861 0.07911893484400442 0.018999240583943065 0.004759036313464044 0.030826406301332925 1.092334705481631e-07 6.961644267793137 -0.8204727972492603 down SINNYNPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SINNYNPK 8 0 Q9Y5A9;Q9Y5A9-2 Q9Y5A9 YTHDF2 YTH domain-containing family protein 2 0 2396000.0 631800.0 520100.0 1244100.0 False True 611743.8548298347 727778.6422856692 918232.8878000176 1.0 1.1896787136310691 1.5010087646167485 19.2225681784635 -6.9637176525108595 0.3794207126405472 0.9784748520940567 1.7232118786060342 0.999884216531974 0.0022223765362422957 0.07839888990856483 0.01641136511232417 0.0040541049805275136 0.026314420612892714 1.0871321701995601e-07 6.9637176525108595 0.7447370265119775 SINPDEAVAYGAAVQAAILSGDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SINPDEAVAYGAAVQAAILSGDK 23 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 9629700.0 3465900.0 4934500.0 1229300.0 False True 4543828.463823343 4198291.834530345 1102103.8282782552 1.0 0.9239547372784732 0.24254961142413042 22.115476941344895 -6.928049937237807 0.7626289852072285 1.0111463105819425 0.10936297747128497 0.9961409103819243 0.021156090076936175 0.09366311616503545 0.08273394430253252 0.019055199708489564 0.0623296319892511 1.1801849245935782e-07 6.928049937237807 -0.9017833331106575 down SINPDEAVAYGAAVQAAILSGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SINPDEAVAYGAAVQAAILSGDK 23 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 97704000.0 34749000.0 16438000.0 46517000.0 False True 33645912.01564095 23001779.123037577 34332802.219912775 1.0 0.6836426105003411 1.0204152648307618 25.003927891988162 -11.038654222931031 12.557241824523915 1.4524464829860635 0.8520289376655479 0.20471192794169657 0.13748686040537172 0.04232511744052732 0.0001302870908804176 0.0032353520188746422 0.04437369338936238 9.148413309858736e-12 11.038654222931031 -0.6004175453205156 SINPDEAVAYGAAVQAAILSGDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SINPDEAVAYGAAVQAAILSGDK 23 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 158620000.0 13501000.0 127520000.0 17599000.0 False True 20482004.055310782 104763059.68169242 14120549.936084265 1.0 5.114883260387227 0.6894125153941147 24.287853546502948 -6.662519412903687 1.963644685985381 3.643240259363855 0.7076908784510707 0.2463545891529304 1.75098738600915 0.4785932043986607 3.5500293408584023 0.7197070366119657 1.9420046234546624 2.1751068048710665e-07 6.662519412903687 -2.935549380912784 SINPDEAVAYGAAVQAAILSGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SINPDEAVAYGAAVQAAILSGDK 23 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 9240400.0 3465900.0 1813900.0 3960600.0 False True 4747336.892425717 1733755.900234837 3025187.8511174363 1.0 0.3652059964400274 0.6372389235624007 22.178687002867786 -10.398518924271748 5.985979187125179 1.0001251565802762 0.5012224600012692 0.8175977732142563 0.11105697744759048 0.00018554286966175246 1.8643592553369728e-05 0.10755711490503207 0.035843485344554074 3.9946715424924314e-11 10.398518924271748 -0.498902696579007 SINPDEAVAYGAAVQAAILSGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SINPDEAVAYGAAVQAAILSGDK 23 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 62403000.0 34749000.0 11279000.0 16375000.0 False True 28895333.141713932 11218237.788293796 19798936.790554445 1.0 0.38823701160582585 0.6851949653410387 24.78433316742244 -10.507999027601185 6.334041181241032 1.000354399329913 0.5367159884734728 0.7644406544878575 0.12123257695204763 0.0006071769836188501 4.716285348521425e-05 0.11746957845307031 0.03912764596275746 3.104566539341345e-11 10.507999027601185 -0.4636384108564403 SINPDEAVAYGAAVQAAILSGDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SINPDEAVAYGAAVQAAILSGDK 23 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 38978000.0 13501000.0 15267000.0 10210000.0 False True 17477310.644496936 14417378.029228412 8351884.76344677 1.0 0.8249197100452064 0.4778701330731636 24.058979868595397 -6.960219491540471 0.4323363064185897 1.0134485738095196 0.2759811879140169 0.9997782351527439 0.0032311855329088973 0.0796229097749037 0.020842928733503654 0.004535951256972706 0.028800546166426882 1.0959241783231197e-07 6.960219491540471 -0.7374673858955028 down SINPLGGFVHYGEVTNDFVMLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SINPLGGFVHYGEVTNDFVMLK 22 0 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 0 8966300.0 4138000.0 3120700.0 1707600.0 False True 5424958.072449006 2655103.7243933277 1530913.9324558254 1.0 0.4894238239144078 0.2821982975740714 22.37118055685297 -13.117041831098216 0.13494238335107384 2.9296677281785475 1.0484850750109483e-23 0.99964602709572 0.0056750663060651085 8.693658886686714 0.10631216399032853 4.672190333904025 0.23843204128418613 7.637622147154151e-14 13.117041831098216 -2.9296677281785475 SINPLGGFVHYGEVTNDFVMLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 SINPLGGFVHYGEVTNDFVMLK 22 0 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 0 172693900.0 83610200.0 24989700.0 64094000.0 False True 80956039.96690956 34968217.529563904 47305858.62121564 1.0 0.4319408106406516 0.5843400769176915 26.270635385322933 -10.496384732158118 9.405481296564123 1.000009017727991 0.5081404437792983 0.9328340470450108 0.062216739925548596 1.1765097698141342e-05 6.299293077731263e-07 0.06024220122854783 0.020080366465580653 3.1887117921896646e-11 10.496384732158118 -0.49186857394869266 SINPLGGFVHYGEVTNDFVMLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 SINPLGGFVHYGEVTNDFVMLK 22 0 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 0 309892900.0 79769900.0 159948000.0 70175000.0 False True 121016770.2608501 131404029.72057194 56304880.491204835 1.0 1.085833223257671 0.46526510639674473 26.8506317462325 -6.871933777308495 1.123870255865707 1.0491566494478037 0.42756926956690133 0.9665726317656005 0.05019692199911195 0.13501139924338448 0.3175505035082257 0.03462192375384318 0.08225204506406097 1.3429697260919706e-07 6.871933777308495 -0.6215873798809024 down SINPLGGFVHYGEVTNDFVMLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SINPLGGFVHYGEVTNDFVMLK 22 0 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 0 9152100.0 4138000.0 1146600.0 3867500.0 False True 5667930.425245285 1095939.4207008455 2954076.1536627524 1.0 0.193357952281748 0.5211913224102274 22.43439061837586 -10.547879581996474 6.313042168595741 1.0008990216984308 0.35727463737729714 0.8367313675798043 0.13383741291195858 0.0016955897598498054 0.00012143266287441152 0.12974652255606878 0.04319583927562508 2.8321771723513598e-11 10.547879581996474 -0.6436243843211337 SINPLGGFVHYGEVTNDFVMLK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SINPLGGFVHYGEVTNDFVMLK 22 0 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 0 164440200.0 83610200.0 26412500.0 54417500.0 False True 69525585.85989028 26270210.62002921 65795947.65190815 1.0 0.3778495397790621 0.9463558895354267 26.05104066075721 -10.616278040751967 9.463274628973785 1.0000789802349148 0.6621027146572482 0.3201986641932143 0.23209174540588684 0.0003868315816033822 1.568548868730274e-05 0.22477372452746794 0.07490728872910096 2.4194795697502385e-11 10.616278040751967 -0.3379762655776666 SINPLGGFVHYGEVTNDFVMLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SINPLGGFVHYGEVTNDFVMLK 22 0 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 0 172803200.0 79769900.0 56794300.0 36239000.0 False True 103263708.04980798 53633647.27879794 29643873.84354039 1.0 0.5193852544296435 0.2870696240080981 26.62175806832495 -10.23616410520245 0.16384023108079712 1.748986167937206 3.9665230696019257e-22 0.999635935594375 0.00566457610764579 1.8770439047700451 0.0800095002526706 0.771010411649828 0.18212088475441812 5.8054500773830444e-11 10.23616410520245 -1.748986167937206 SIPAYLAETLYYAMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIPAYLAETLYYAMK 15 0 P08758;D6RBL5;D6RBE9 P08758 ANXA5 Annexin A5;Annexin 0 9571900.0 5242500.0 4329400.0 0.0 False True 5076079.707099417 6058151.997522739 0.0 1.0 1.1934706204573173 0.0 22.275283292587947 -6.918260029848069 1.2624455308994535 1.1017975928985833 2.5871744516267895e-16 0.9582251026841462 0.10689640227263268 0.12328554654437222 0.3933159577680638 0.06960203284805845 0.13615383984503768 1.2070908840739715e-07 6.918260029848069 -1.101797592898583 down SIPAYLAETLYYAMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIPAYLAETLYYAMK 15 0 P08758;D6RBL5;D6RBE9 P08758 ANXA5 Annexin A5;Annexin 0 8401840.0 546140.0 4360500.0 3495200.0 False True 748062.7168785552 4167838.6917547826 2669705.7459035655 1.0 5.571509711305948 3.568826096618555 19.512799703823294 -9.620798160057113 13.242520248969953 0.9999969513858575 4.5701679039624 0.8090626742634559 0.8175921620380127 0.0 0.0 0.7916302068898786 0.2638767356299595 2.394428317136912e-10 9.620798160057113 3.570170952576542 SIPICTLK(ub)NFPNAIEHTLQWAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIPICTLKNFPNAIEHTLQWAR 22 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 389247000.0 246180000.0 86709000.0 56358000.0 True False 238365150.65211928 121332355.88146141 41596149.09624101 1.0 0.5090188542642261 0.17450600048892334 27.828598086105046 -8.238146135422163 0.3105577256947228 1.1375958105188144 5.0789303708679916e-26 0.9988247396319176 0.0116222535452378 0.09661974790860091 0.07317003823741693 0.08183879790506561 0.09359534094830803 5.779015570271981e-09 8.238146135422163 -1.1375958105188144 down SIPICTLK(ub)NFPNAIEHTLQWAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIPICTLKNFPNAIEHTLQWAR 22 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 2583220000.0 572650000.0 1236860000.0 773710000.0 True False 868751916.3227707 1016132669.3687115 620785879.3708605 1.0 1.1696465357679668 0.714572097864838 29.694369014172114 -6.805744437254573 1.432209041068613 1.092934351845589 0.7073534572419448 0.8484400486929162 0.073102898737769 0.21267407926273993 0.8605280191410636 0.040142378574478166 0.09305516566214946 1.564067755332789e-07 6.805744437254573 -0.3855808946036442 SIPICTLK(ub)NFPNAIEHTLQWAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIPICTLKNFPNAIEHTLQWAR 22 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 72688000.0 47196900.0 17376300.0 8114800.0 True False 64646869.378264695 16608557.610260004 6198251.369552038 1.0 0.25691201708592043 0.0958786006060796 25.94607717126469 -13.999999999999691 0.21490720723789136 5.3866035268292976 0.005422469381156177 0.9994933277174057 0.0088636880487337 12.866069836173983 0.1468992747078785 23.888597092181453 0.09221162152058186 1.0000000000007117e-14 13.999999999999691 -5.381181057448141 SIPICTLK(ub)NFPNAIEHTLQWAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIPICTLKNFPNAIEHTLQWAR 22 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 537901000.0 246180000.0 111819000.0 179902000.0 True False 204709577.6231586 111216608.85266624 217518676.42713463 1.0 0.5432897187517054 1.0625720542863695 27.609003361539322 -6.674429699748694 1.9214681169343044 0.7096044940852761 1.0605281888662692 0.29889389485462214 0.19380428084540752 0.45103113794410304 3.214414531998919 0.08107554796016206 0.21538598741160575 2.1162662224200178e-07 6.674429699748694 0.35092369478099306 SIPICTLK(ub)NFPNAIEHTLQWAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIPICTLKNFPNAIEHTLQWAR 22 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 1823473300.0 572650000.0 872980000.0 377843300.0 True False 741306713.6190783 824397895.5889056 309079696.3996525 1.0 1.1120874537398617 0.4169390222984998 29.465495336264564 -6.865576451232106 1.157147861865855 1.0619847682618382 0.37949347093476166 0.960070408214595 0.060892763117869675 0.1411719074362628 0.3560655034438459 0.04093801563720216 0.09625110117309649 1.362773088693839e-07 6.865576451232106 -0.6824912973270765 down SIPMTVDFIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIPMTVDFIR 10 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 10706500.0 3730000.0 2105000.0 4871500.0 False True 3611593.1916987747 2945537.4774299804 3595508.0081326147 1.0 0.815578422342882 0.9955462360480877 21.784203966746592 -10.720488395969427 8.340619814136053 1.0004403979049572 0.905562329198932 0.26854958129004625 0.07347155228366918 0.0006044422158544511 2.0256064952866294e-05 0.07146523738483575 0.023712841534554868 1.9033190921895097e-11 10.720488395969427 -0.09487806870602522 SIPMTVDFIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIPMTVDFIR 10 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 17631100.0 2288100.0 12986000.0 2357000.0 False True 3471214.982516603 10668546.83991891 1891137.9168902012 1.0 3.073433046830277 0.5448057600624728 21.727009287589553 -6.688766920503124 1.8705530927522993 2.3013920076392953 0.5536146830045214 0.3647609223393644 0.8771345587178002 0.41932973187781075 2.8436518333003953 0.3752416060745654 0.9787648199725412 2.0475432284046057e-07 6.688766920503124 -1.7477773246347739 SIPMTVDFIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIPMTVDFIR 10 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 8324100.0 3730000.0 2554400.0 2039700.0 False True 3101660.2670175526 2540638.940191296 2466191.83949276 1.0 0.819122251140124 0.7951199122991518 21.564609242180868 -13.999999999999998 0.28465765249291164 2.5126627557339583 0.7882198432428209 0.9996155221785504 0.0017931615351039374 15.655940570815758 0.16908923258138464 13.8248807268046 0.009289480303201625 1.0000000000000041e-14 13.999999999999998 -1.7244429124911373 SIPNGAVPGAQASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIPNGAVPGAQASR 14 0 A0A0A0MRY4;Q96N96-6 A0A0A0MRY4 0 15116200.0 3271300.0 3720700.0 8124200.0 False True 4288705.97931426 3165586.0631750077 7283585.716829249 1.0 0.7381214936261886 1.6983178030763146 22.032110981887705 -6.83405044935693 1.309876222805727 0.860418209637868 1.7263295661013496 0.9137045477810651 0.1190529171577224 0.17586817980064276 0.5887217547479111 0.07133323022511512 0.16415501840923857 1.4653776070362377e-07 6.83405044935693 0.8659113564634816 SIPNGAVPGAQASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIPNGAVPGAQASR 14 0 A0A0A0MRY4;Q96N96-6 A0A0A0MRY4 0 16701100.0 3007100.0 8425800.0 5268200.0 False True 2911641.2565033236 11790265.879966548 3888300.3773877174 1.0 4.0493539008737045 1.3354325051903175 21.47340118126654 -6.618190224440949 2.123798681571256 3.0259166480835757 1.3457593266012347 0.07664262375853981 1.3119388904936473 0.5902515551473281 5.056645275298882 0.5080775385179359 1.454640368269029 2.4088501020586436e-07 6.618190224440949 -1.680157321482341 SIPNGAVPGAQASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIPNGAVPGAQASR 14 0 A0A0A0MRY4;Q96N96-6 A0A0A0MRY4 0 10334400.0 3271300.0 3933200.0 3129900.0 False True 4480788.013558452 3759418.2186469296 2390682.0823139073 1.0 0.8390082742748097 0.5335405457879113 22.095321043410596 -6.961061746889493 0.42020648794794024 1.0134722496626167 0.34754973396588085 0.9998075628947344 0.0026835936696662224 0.07932405374865524 0.01974623384681128 0.003952005711761047 0.02542638970205482 1.0938008413829452e-07 6.961061746889493 -0.6659225156967359 SIPNGAVPGAQASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIPNGAVPGAQASR 14 0 A0A0A0MRY4;Q96N96-6 A0A0A0MRY4 0 8799700.0 3007100.0 4378600.0 1414000.0 False True 2500536.887117558 4355011.612715949 1709660.8624026866 1.0 1.7416306214686952 0.6837175133110964 21.253806456700815 -6.718294208841432 1.76572560336306 1.4520249850027571 0.6855525910593988 0.504345876909372 0.31214784746640784 0.3586352115469527 2.184349567088194 0.14042640890753882 0.35319577415771025 1.9129595689306397e-07 6.718294208841432 -0.7664723939433583 SIQADGLVWGSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIQADGLVWGSSK 13 0 P24534 P24534 EEF1B2 Elongation factor 1-beta 0 96461000.0 27771000.0 34757000.0 33933000.0 False True 36408049.93474657 29571391.081724834 30421938.668320164 1.0 0.8122212295007575 0.8355827549908551 25.11775413433171 -10.339398855548136 5.602189077760296 1.0000350703614866 0.8239019922982859 0.9869725324381583 0.009537302843965936 4.178429294599274e-06 4.927121915617046e-07 0.009236290979446494 0.0030781512568672366 4.577213228897206e-11 10.339398855548136 -0.17613307806320078 SIQADGLVWGSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIQADGLVWGSSK 13 0 P24534 P24534 EEF1B2 Elongation factor 1-beta 0 77279000.0 23790000.0 11334000.0 42155000.0 False True 23034799.471987624 15859725.306029176 31113340.87710773 1.0 0.6885115420829263 1.3507102987783477 24.45731170291649 -6.778796989007896 1.5404704529808504 0.8233452338992806 1.3557653142765818 0.7630940318410911 0.13166020196595443 0.252472889714407 1.1833036935343242 0.06731994136605339 0.1590130687668694 1.6641903945176543e-07 6.778796989007896 0.5324200803773012 SIQADGLVWGSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIQADGLVWGSSK 13 0 P24534 P24534 EEF1B2 Elongation factor 1-beta 0 99906000.0 27771000.0 43088000.0 29047000.0 False True 38038689.18305625 41184229.6870382 22186696.84174324 1.0 1.0826931887385616 0.5832665982513919 25.180964195854603 -6.864378466115017 1.1634924954705286 1.0454990021026649 0.5569884591568192 0.958739339531276 0.04439628386087539 0.1423547904400206 0.3637402361710745 0.02970495848558466 0.06971516671083314 1.3665374369098033e-07 6.864378466115017 -0.4885105429458457 SIQADGLVWGSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIQADGLVWGSSK 13 0 P24534 P24534 EEF1B2 Elongation factor 1-beta 0 52575000.0 23790000.0 14645000.0 14140000.0 False True 19782439.075696398 14566104.47819509 17096608.62402686 1.0 0.7363148913265298 0.8642315822941571 24.237716978350765 -10.096154898985008 4.716033207128455 1.0000109112044169 0.80027323680725 0.7647363180423132 0.05222177041994137 13016817.159529986 27866598.89841359 909.5461720267608 0.01787689935551485 8.013921813864954e-11 10.096154898985008 -0.19973767439716683 SIQADGLVWGSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIQADGLVWGSSK 13 0 P24534 P24534 EEF1B2 Elongation factor 1-beta 0 109227000.0 27203000.0 46488000.0 35536000.0 False True 35214819.7512962 43900901.93376369 29068812.630151283 1.0 1.2466598507052638 0.8254710044080605 25.069679362455567 -6.747987722505711 1.6573939633010284 1.145388760115804 0.8247656293146867 0.6402338575347271 0.10363917142206043 0.30356352093173444 1.640032144356602 0.049411611500102134 0.12020778601859454 1.7865380795255954e-07 6.747987722505711 -0.32062313080111726 SIQADGLVWGSSK(ub)LVPVGYGIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIQADGLVWGSSKLVPVGYGIK 22 1 P24534 P24534 EEF1B2 Elongation factor 1-beta 1 14526300.0 4072100.0 7230800.0 3223400.0 True False 3942833.4144548425 10118096.14812385 2379094.8400728083 1.0 2.5661992492581205 0.6033972501477735 21.91080132688711 -6.694148716973122 1.8514930262601488 1.978047530977075 0.609784729069626 0.390004590391116 0.6618424030556674 0.407805479441299 2.7134747476308982 0.2856179596349822 0.7399526061007704 2.0223265477666912e-07 6.694148716973122 -1.368262801907449 SIQADGLVWGSSK(ub)LVPVGYGIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIQADGLVWGSSKLVPVGYGIK 22 1 P24534 P24534 EEF1B2 Elongation factor 1-beta 1 12653100.0 4072100.0 6299700.0 2281300.0 True False 3386131.574617201 6265762.26570746 2758309.282460569 1.0 1.8504190187635572 0.8145901072294846 21.691206602321387 -6.6885504703455645 1.8717731483650606 1.5338810024092802 0.8182488962419041 0.36360971500472006 0.3597733950085833 0.4197613417528984 2.8502386224119296 0.15383830702672135 0.40130858123070573 2.0485639678643541e-07 6.6885504703455645 -0.715632106167376 SIQEIQELDKDDESLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIQEIQELDKDDESLR 16 1 P52565;J3KTF8;J3QQX2;J3KRE2;J3KRY1;P52565-2;J3KS60 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 0 37656400.0 2528400.0 19972000.0 15156000.0 False True 3314756.8850604333 16992255.450246256 13587802.506617762 1.0 5.12624486182686 4.099185242772347 21.66047163164406 -9.898702096511157 6.11109532272842 0.9999993361504529 4.612715052300634 0.9428485699535346 0.41929533368714916 3.8416876874918076e-06 6.909749465620764e-07 0.4059810336841218 0.13532698704219467 1.2626933797601268e-10 9.898702096511157 3.6127157161501806 SIQEIQELDKDDESLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIQEIQELDKDDESLR 16 1 P52565;J3KTF8;J3QQX2;J3KRE2;J3KRY1;P52565-2;J3KS60 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 0 29679900.0 8972700.0 5008200.0 15699000.0 False True 8687866.549907662 7008000.377417984 11586960.940095246 1.0 0.8066422679446507 1.3336946272751389 23.050570512099842 -6.807441657354031 1.425570272310956 0.8942990256433327 1.3423580771276782 0.8529557520568426 0.08347842566073341 0.2103170711909556 0.84291727730934 0.046053842001853126 0.10664556594482516 1.5579673164002223e-07 6.807441657354031 0.44805905148434544 SIQEIQELDKDDESLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIQEIQELDKDDESLR 16 1 P52565;J3KTF8;J3QQX2;J3KRE2;J3KRY1;P52565-2;J3KS60 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 0 27826400.0 2528400.0 11617000.0 13681000.0 False True 3463217.807440837 11103722.52771822 10449829.569039445 1.0 3.2061866001790325 3.017375790395754 21.723681693166952 -10.058527213490914 4.851912874650116 0.9999443812977786 3.1117811953130126 0.9940403445643308 0.07708169040859617 5018042.127689209 10476415.09262843 1904.596125184159 0.02638711341198029 8.739222297032278e-11 10.058527213490914 2.111836814015234 SIQEVQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIQEVQKR 8 1 P42285 P42285 SKIV2L2 Superkiller viralicidic activity 2-like 2 1 1963390.0 194210.0 286980.0 1482200.0 True False 188044.9098551792 401572.61058092955 1093967.3549531281 1.0 2.1355143879735774 5.817585574614253 17.520717729360207 -6.949690179492885 0.5622340613876952 0.9523947487124725 7.177353641054157 0.9991767499692629 0.059000700938472594 0.08361037731964308 0.0364789838587806 0.06307609014879083 0.3062307168289976 1.1228191744722886e-07 6.949690179492885 6.224958892341685 SIQFALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIQFALR 7 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8 F8WF16 PPHLN1 Periphilin-1 0 14713900.0 3992200.0 4332900.0 6388800.0 False True 5233812.860519791 3686448.209511914 5727748.261696999 1.0 0.7043523159415749 1.09437391330957 22.31943090983034 -6.703939114163089 1.8163355315858685 0.8171389783434607 1.0933249399380554 0.4365935369908963 0.12470745229792778 0.3873410230965203 2.486877054033844 0.054713213003567206 0.1400531696075786 1.977246820444753e-07 6.703939114163089 0.27618596159459463 SIQFALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIQFALR 7 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8 F8WF16 PPHLN1 Periphilin-1 0 11362200.0 4375300.0 1869400.0 5117500.0 False True 4236408.49641814 2615861.168792212 3777073.228290806 1.0 0.6174714197188275 0.8915743681196704 22.014410277479342 -9.966579920058512 6.140654724791525 1.0000001106968082 0.7545228939192253 0.5167641957260038 0.1119020600958327 1.694453878634489e-07 2.865867048330159e-08 0.10834875222471872 0.036116234596442795 1.0799908597219937e-10 9.966579920058512 -0.24547721677758283 SIQFALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIQFALR 7 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8 F8WF16 PPHLN1 Periphilin-1 0 19386900.0 4173200.0 6351500.0 8862200.0 False True 6331049.501786762 5218025.200503991 7110582.285559746 1.0 0.8241959250249661 1.1231285245128764 22.594013245205073 -6.747351674855501 1.6598844715290695 0.8962961150292444 1.1235962095483767 0.637404361964482 0.07386605660064026 0.30468420307813787 1.650855702840502 0.035168054839963964 0.08560931868636644 1.789156477650845e-07 6.747351674855501 0.22730009451913225 SIQFALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIQFALR 7 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8 F8WF16 PPHLN1 Periphilin-1 0 15156600.0 3992200.0 5557200.0 5607200.0 False True 5468224.225148429 5311664.528797088 4282894.843908922 1.0 0.9713691886241019 0.783233215677557 22.382640971353233 -6.933942313610247 0.7136872800667071 1.0024853154285562 0.7404226676085348 0.9972579582276557 0.005034823151630271 0.09064184678825349 0.06802589732380944 0.004699720776609364 0.016669476104452106 1.1642806680044058e-07 6.933942313610247 -0.2620626478200214 SIQFALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIQFALR 7 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8 F8WF16 PPHLN1 Periphilin-1 0 19635000.0 4173200.0 9201300.0 6260500.0 False True 5402289.666070269 8689239.566407239 5121153.238154609 1.0 1.6084364414927719 0.9479597642308275 22.365139567297522 -6.664569780936639 1.9568334735220625 1.3901669280086923 0.9506958661308678 0.2551264355807684 0.25877949260590416 0.47371276415934194 3.491708542384522 0.1066702314504974 0.28700755720014226 2.164862008814509e-07 6.664569780936639 -0.4394710618778246 SIQFVDWCPTGFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIQFVDWCPTGFK 13 0 P68363;P68363-2;P68366-2;P68366 P68363;P68366-2 TUBA1B;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 331554000.0 81984000.0 128550000.0 121020000.0 False True 107481817.93418536 109370841.0839754 108498011.30581176 1.0 1.017575280974004 1.0094545606983374 26.679517387334606 -10.189949171199746 3.767766680841596 0.9999880124360948 1.0135149208456862 0.7869151444994267 0.003315270200843551 3.3413619177668755e-07 7.182993379014064e-08 0.0032128438884567526 0.0010699988521666167 6.457297993026273e-11 10.189949171199746 0.013526908409591365 SIQFVDWCPTGFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIQFVDWCPTGFK 13 0 P68363;P68363-2;P68366-2;P68366 P68363;P68366-2 TUBA1B;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 135590000.0 87431000.0 25544000.0 22615000.0 False True 84655550.76230969 35743852.410200275 16691453.064542577 1.0 0.42222691942031687 0.19716903279511755 26.335101331206786 -10.943287799756177 0.18814788503324628 1.9750357670603929 5.577449189366959e-11 0.9994403715392967 0.007999049781337985 3.0084588555241103 0.10480588319004379 1.4302930114759058 0.15078057416006535 1.1394944132374485e-11 10.943287799756177 -1.9750357670046184 SIQFVDWCPTGFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIQFVDWCPTGFK 13 0 P68363;P68363-2;P68366-2;P68366 P68363;P68366-2 TUBA1B;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 496566000.0 107730000.0 305840000.0 82996000.0 False True 163434286.11796382 251260462.46117327 66591804.22156088 1.0 1.537379141362163 0.40745308590570867 27.28413543060906 -6.7773826234711505 1.5459836686847928 1.3053221084962747 0.39921817773125073 0.7580015780479881 0.22701426192928315 0.25468870668741633 1.2021391843832112 0.11567428926530252 0.27355561780439835 1.6696189932370718e-07 6.7773826234711505 -0.906103930765024 down SIQFVDWCPTGFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIQFVDWCPTGFK 13 0 P68363;P68363-2;P68366-2;P68366 P68363;P68366-2 TUBA1B;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 378994000.0 81984000.0 132160000.0 164850000.0 False True 112295700.33429413 126320734.20532335 125915825.19232185 1.0 1.1248937744657896 1.121288035227367 26.742727448857497 -10.117663676296166 4.2493862438465 0.9999781020290455 1.1230909048615352 0.9993568307645303 0.001472036930401819 775928.4897341559 0.007410979495181655 166.4191346580247 0.0005387103474712102 7.626694032142457e-11 10.117663676296166 0.12311280283248971 SIQFVDWCPTGFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIQFVDWCPTGFK 13 0 P68363;P68363-2;P68366-2;P68366 P68363;P68366-2 TUBA1B;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 168659000.0 87431000.0 18629000.0 62599000.0 False True 72702750.35002983 18528641.87943301 75688161.4749263 1.0 0.2548547584544772 1.041063248783892 26.115506606641063 -11.840059485584083 17.730953070146967 0.937132572421685 0.6831631034099233 0.0 0.3705519178459847 0.0 0.0 0.0 0.1073181120310039 1.4452418015238654e-12 11.840059485584083 -0.25396946901176176 SIQFVDWCPTGFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIQFVDWCPTGFK 13 0 P68363;P68363-2;P68366-2;P68366 P68363;P68366-2 TUBA1B;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain 0 281793000.0 107730000.0 85299000.0 88764000.0 False True 139458608.67577615 80552035.6661528 72609862.79555225 1.0 0.5776053298611793 0.5206552932444717 27.055261752701508 -13.999999999999998 0.28237725041261896 4.487982486892913 0.5039087830037594 0.9996104496927499 0.0042199674540669705 15.528297979265659 0.168370786623771 31.322811455982084 0.02227655857675698 1.0000000000000041e-14 13.999999999999998 -3.9840737038891536 SIQFVDWCPTGFK(ub)VGINYQPPTVVPGGDLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIQFVDWCPTGFKVGINYQPPTVVPGGDLAK 31 1 P68363;P68363-2;P68366-2;P68366 P68363;P68366-2 TUBA1B;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain 1 561182000.0 196030000.0 92222000.0 272930000.0 True False 297391841.71265644 75764263.5662253 218985265.87053117 1.0 0.2547624142273198 0.7363526336479579 28.147789829884886 -10.60328026995842 6.7522360278741544 1.0010569790861024 0.49555752436938105 0.5939701832219779 0.19660838378259216 0.003134074878920626 0.00018413863493340967 0.19071249455789546 0.06345508300956132 2.4929853709916384e-11 10.60328026995842 -0.5054994547167213 SIQFVDWCPTGFK(ub)VGINYQPPTVVPGGDLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIQFVDWCPTGFKVGINYQPPTVVPGGDLAK 31 1 P68363;P68363-2;P68366-2;P68366 P68363;P68366-2 TUBA1B;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain 1 453722000.0 196030000.0 25742000.0 231950000.0 True False 253764699.32899308 24309435.070963394 189737480.0079804 1.0 0.09579518008313458 0.7476905988487996 27.918916151977335 -10.459940889795208 8.148223762728108 1.0000229931517577 0.4217428896622376 0.5119854462185289 0.26613519027230687 0.00011116876227223352 7.368000834888589e-06 0.25769448654032595 0.08589476331369886 3.467840467259185e-11 10.459940889795208 -0.5782801034895201 SIQFVDWCPTGFK(ub)VGINYQPPTVVPGGDLAK(ub)VQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQR 34 2 P68363;P68363-2;P68366-2;P68366 P68363;P68366-2 TUBA1B;TUBA4A Tubulin alpha-1B chain;Tubulin alpha-4A chain 2 129299000.0 31725000.0 23776000.0 73798000.0 True False 48129144.40817237 19532987.037264124 59211792.95318748 1.0 0.40584529971298233 1.2302689707306176 25.520407440951715 -6.713307159547097 1.7831838359136285 0.6359699268982988 1.2285468030515672 0.48087983943926416 0.2502483433864528 0.36847614186767275 2.2858784837047477 0.11158939308172783 0.28238307052644535 1.9350528924254834e-07 6.713307159547097 0.5925768761532684 SIQGHHVCLLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIQGHHVCLLVK 12 0 O14617-5;O14617-4;O14617-2;O14617;A0A2R8Y611;O14617-3 O14617-5 AP3D1 AP-3 complex subunit delta-1 0 23967400.0 7897900.0 7366000.0 8703500.0 False True 10354223.383372385 6267021.512443116 7802945.309867239 1.0 0.6052623437221941 0.753600248029979 23.30371601275067 -10.193496098213847 4.840247036243694 1.0000400168091115 0.6794312958751705 0.861629403431952 0.060558695847806376 2.6154277552473955e-05 4.3580113688221736e-06 0.05864301225031324 0.019545235040099654 6.404775357183314e-11 10.193496098213847 -0.320608720933941 SIQGHHVCLLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIQGHHVCLLVK 12 0 O14617-5;O14617-4;O14617-2;O14617;A0A2R8Y611;O14617-3 O14617-5 AP3D1 AP-3 complex subunit delta-1 0 4260720.0 2850800.0 312720.0 1097200.0 False True 2760302.914449023 437590.72681325657 809810.4047055552 1.0 0.15852996586811305 0.2933773682832195 21.396395165745634 -10.16248256873923 7.328626572079645 1.00000056352664 0.22595366889256213 0.9777444724892157 0.055051221509459854 5.06854721633399e-07 5.798351259136847e-08 0.05330315414411254 0.017767705341209472 6.87887521469489e-11 10.16248256873923 -0.7740468946340779 SIQGHHVCLLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIQGHHVCLLVK 12 0 O14617-5;O14617-4;O14617-2;O14617;A0A2R8Y611;O14617-3 O14617-5 AP3D1 AP-3 complex subunit delta-1 0 11222300.0 4611400.0 0.0 6610900.0 False True 6995830.938497898 0.0 5304252.717339597 1.0 0.0 0.7582019582763807 22.738063994784746 -10.793244688175198 9.667454857742497 1.0062262037795375 0.3791009800775023 0.47205899512146954 0.30953465329268565 0.041163807763861034 0.0008803578896376446 0.2970048960773993 0.09990187977305483 1.6097384283037634e-11 10.793244688175198 -0.6271252237020353 SIQGHHVCLLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIQGHHVCLLVK 12 0 O14617-5;O14617-4;O14617-2;O14617;A0A2R8Y611;O14617-3 O14617-5 AP3D1 AP-3 complex subunit delta-1 0 17183400.0 7897900.0 2931400.0 6354100.0 False True 10817967.062722247 2801881.0551565117 4853392.446797279 1.0 0.25900255000882233 0.4486418213937476 23.36692607427356 -10.90742880655901 11.341354633067903 1.0576062107756306 0.3538221857012904 0.9393223973324438 0.07741990834770832 0.03765209259911169 0.00030732600031290375 0.025028707246471688 0.02498716797463157 1.2375740475292965e-11 10.90742880655901 -0.7037840250743401 SIQGHHVCLLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIQGHHVCLLVK 12 0 O14617-5;O14617-4;O14617-2;O14617;A0A2R8Y611;O14617-3 O14617-5 AP3D1 AP-3 complex subunit delta-1 0 18711200.0 4611400.0 7869200.0 6230600.0 False True 5969548.20428362 7431272.102417265 5096694.731354697 1.0 1.244863404752263 0.8537823227053293 22.509190316877195 -6.7374256991987735 1.696057952569901 1.1461269294654772 0.853677378849581 0.5933260048275475 0.10288960698824301 0.32251010605716524 1.8205844069465666 0.048010364050029904 0.11815056592861714 1.8305192519275186e-07 6.7374256991987735 -0.2924495506158963 SIQK(ub)LIEWENNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIQKLIEWENNR 12 1 B7Z4S5;Q5VXU3-2;Q5VXU3 B7Z4S5 CHIC1 Cysteine-rich hydrophobic domain-containing protein 1 1 17847600.0 4687700.0 7608600.0 5551300.0 True False 6145620.095751382 6473426.538090507 4976904.727829723 1.0 1.0533398480920981 0.8098295453164082 22.551127155826205 -6.849303058786928 1.2384561384866644 1.028447832651926 0.8002253910020825 0.9392848474115545 0.025752533640744334 0.1582247962178296 0.4673523660737402 0.016274299172742656 0.037643173126644745 1.4148061572906693e-07 6.849303058786928 -0.2282224416498435 SIQK(ub)LIEWENNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIQKLIEWENNR 12 1 B7Z4S5;Q5VXU3-2;Q5VXU3 B7Z4S5 CHIC1 Cysteine-rich hydrophobic domain-containing protein 1 1 16150660.0 5064800.0 5589060.0 5496800.0 True False 4904020.696331356 7820800.804562862 4057023.179534716 1.0 1.594773205262677 0.8272850851893285 22.225533636940064 -6.699837320501583 1.8315959838099125 1.3693966817649563 0.8295880643005034 0.4167076283624691 0.2510696979443968 0.3958780454982049 2.5818813697484906 0.10936541157319685 0.2813002129128601 1.996009847084566e-07 6.699837320501583 -0.539808617464453 SIQK(ub)LIEWENNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIQKLIEWENNR 12 1 B7Z4S5;Q5VXU3-2;Q5VXU3 B7Z4S5 CHIC1 Cysteine-rich hydrophobic domain-containing protein 1 1 14253400.0 4687700.0 4616300.0 4949400.0 True False 6420869.370329225 4412336.601937305 3780453.656092672 1.0 0.6871867884941982 0.5887759800194833 22.614337217349096 -13.999999999999998 0.1618775701881954 2.5468321722102276 0.49400984863201 0.9995315549420216 0.003794605408253438 12.0227234794975 0.1272063870189275 5.838411560843275 0.08657896607481944 1.0000000000000041e-14 13.999999999999998 -2.0528223235782175 SIQK(ub)LIEWENNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIQKLIEWENNR 12 1 B7Z4S5;Q5VXU3-2;Q5VXU3 B7Z4S5 CHIC1 Cysteine-rich hydrophobic domain-containing protein 1 1 15142600.0 5064800.0 6468700.0 3609100.0 True False 4211605.608683781 6433851.8291635765 4363746.123407028 1.0 1.52764822420642 1.0361241124785172 22.00593891237434 -10.480145484852725 3.2463602846895867 0.9942160861252604 1.281886168340025 0.30484459723749746 0.2006638793845562 73041219.6321869 75618603.00162172 3678345.346264224 0.07343545445704282 3.3102021403080166e-11 10.480145484852725 0.28767008221476453 SIQLDGLVWGASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIQLDGLVWGASK 13 0 P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;H0YE72;H0YE58;E9PQC9;P29692-3 P29692;P29692-3 EEF1D Elongation factor 1-delta 0 64287000.0 18698000.0 24698000.0 20891000.0 False True 24513259.071689565 21013154.672049955 18729399.72062233 1.0 0.857215868791519 0.7640518001236715 24.547058969468598 SIQLDGLVWGASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIQLDGLVWGASK 13 0 P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;H0YE72;H0YE58;E9PQC9;P29692-3 P29692;P29692-3 EEF1D Elongation factor 1-delta 0 126187000.0 49152000.0 27556000.0 49479000.0 False True 47591696.664444536 38559254.50264162 36518965.561817504 1.0 0.8102097047413945 0.7673390133430691 25.504206552325147 -13.999999999999998 0.20904124358775217 2.0933225783325478 0.74185226200248 0.999489492900828 0.002284268307347856 12.724424254232707 0.14492320256487454 5.711262211622707 0.025566142190810007 1.0000000000000041e-14 13.999999999999998 -1.3514703163300679 SIQLDGLVWGASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIQLDGLVWGASK 13 0 P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;H0YE72;H0YE58;E9PQC9;P29692-3 P29692;P29692-3 EEF1D Elongation factor 1-delta 0 155580000.0 32907000.0 86042000.0 36631000.0 False True 49922324.823947266 70687132.85078569 29390866.794062357 1.0 1.4159423284085066 0.5887319330121389 25.573181784587224 -6.770014509776326 1.5746023924515316 1.238568865757412 0.5840984471609199 0.7305564560555936 0.17529783817473193 0.26639889063948097 1.3035574724572714 0.087755688279198 0.20887478839055026 1.6981869150981694e-07 6.770014509776326 -0.6544704185964922 SIQLDGLVWGASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIQLDGLVWGASK 13 0 P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;H0YE72;H0YE58;E9PQC9;P29692-3 P29692;P29692-3 EEF1D Elongation factor 1-delta 0 110621000.0 18698000.0 24238000.0 67685000.0 False True 25611155.89445052 23167085.015652426 51699197.01633175 1.0 0.9045700674787709 2.0186202149327452 24.61026903099149 -6.886067717206158 1.0454046199444011 0.9343767411741362 2.1073565655341797 0.9782581630511823 0.07434231053771173 0.1223899497542812 0.24097043772533955 0.05444668795870941 0.1339455877084279 1.299966865377986e-07 6.886067717206158 1.1729798243600436 up SIQLDGLVWGASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIQLDGLVWGASK 13 0 P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;H0YE72;H0YE58;E9PQC9;P29692-3 P29692;P29692-3 EEF1D Elongation factor 1-delta 0 86888000.0 49152000.0 17588000.0 20148000.0 False True 40872065.80280072 17493249.953055356 24360853.64617352 1.0 0.4280001416482513 0.5960269726445834 25.284611827759424 -10.860935909026937 11.058471863809816 1.014143973024455 0.5120135571464878 0.9183404917767676 0.068596666506313 0.021788413816906327 0.000273996246166009 0.06049821282419347 0.022139478915357863 1.377412725467417e-11 10.860935909026937 -0.5021304158779673 SIQLDGLVWGASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIQLDGLVWGASK 13 0 P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;H0YE72;H0YE58;E9PQC9;P29692-3 P29692;P29692-3 EEF1D Elongation factor 1-delta 0 131737000.0 32907000.0 58272000.0 40558000.0 False True 42598760.19394569 55029111.974795245 33176860.160222735 1.0 1.2918007877284703 0.7788222006737643 25.344308106679673 -6.7523743969615095 1.6408305380284653 1.1710858934553394 0.7775997345040646 0.6592464856810372 0.12263413758082688 0.2959062079651386 1.568118908238253 0.05902047017396 0.142943151581524 1.7685836388288685e-07 6.7523743969615095 -0.3934861589512748 SIQPEEK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIQPEEKER 9 1 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 7989020.0 2436870.0 2271850.0 3280300.0 True False 3194760.1686826507 1932898.835601938 2940886.022859477 1.0 0.6050215770653491 0.9205342083853957 21.60727620114147 -9.890028475464343 6.4037627710289176 1.000000018499536 0.7627778927253511 0.4297866573852046 0.12880749235624042 3.4011671345734164e-08 5.804191081588853e-09 0.12471732748273621 0.04157243939686028 1.2881650875723324e-10 9.890028475464343 -0.23722212577418478 SIQPEEK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIQPEEKER 9 1 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 9675120.0 2039920.0 3064100.0 4571100.0 True False 1975163.8561957555 4287611.109070408 3373791.779939442 1.0 2.170762236065072 1.7081072891023328 20.91354091107737 -10.254732468970552 5.103711332086992 0.9998523490375073 1.939434762584045 0.8460923523047571 0.18887809117337964 0.0003173749699933342 4.634453167854429e-05 0.1829086069526134 0.06096014179799101 5.5624680699428194e-11 10.254732468970552 0.9395824135465376 SIQPEEK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIQPEEKER 9 1 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 20043600.0 3416300.0 4655300.0 11972000.0 True False 5182776.864984686 3824525.3429750837 9605728.952485984 1.0 0.7379297705857119 1.8533942715888787 22.30529385177731 -6.8448040662125615 1.2600808900055374 0.8605559675622917 1.8936682488222878 0.9323706134435531 0.12384878879796679 0.16326776985654512 0.5015107535470266 0.07700540811405233 0.17768333994291396 1.4295387554883036e-07 6.8448040662125615 1.0331122812599962 SIQPEEK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIQPEEKER 9 1 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 9979150.0 2436870.0 2153480.0 5388800.0 True False 3337846.6929355916 2058332.1329939428 4116076.4258197355 1.0 0.6166646710738135 1.2331532285563724 21.67048626266436 -6.738521944607943 1.6919570598677884 0.7715329588914661 1.2334116931127332 0.5983853035987632 0.16106746157908625 0.32048078609351394 1.800807834500664 0.07532501662590912 0.185152346589743 1.8259044850189495e-07 6.738521944607943 0.46187873422126713 SIQPEEK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIQPEEKER 9 1 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 6926420.0 2039920.0 3564600.0 1321900.0 True False 1696283.8637786729 3545396.7922822973 1598303.1782249722 1.0 2.0900963971823128 0.942238037131688 20.693946186511646 -6.657876553819701 1.980803921207229 1.7029104941281206 0.9470723352651228 0.2265329955288462 0.4643756937639771 0.4894497651860556 3.6895347373274032 0.18957282693639022 0.5145503501183195 2.198484692996552e-07 6.657876553819701 -0.7558381588629978 SIQPEEK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIQPEEKER 9 1 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 1 31651700.0 3416300.0 4342800.0 23892600.0 True False 4422467.695340708 4101119.3623719886 19544391.958778497 1.0 0.927337324971921 4.419340808157739 22.07642017386976 -6.902151908210293 0.9475961598050403 0.863262950386707 4.802291005964153 0.9876059364881982 0.18138657014556242 0.10983753559056188 0.16863478537414947 0.14296696738244222 0.3761430459151144 1.252702925890817e-07 6.902151908210293 3.939028055577446 up SIRPDNMSEYSK(ub)QMQR ddPTM_RPMI8226_Bortezomib_1h_R1 4 SIRPDNMSEYSKQMQR 16 2 Q92769-3;Q92769;H3BM24;E5RJ04;E5RGV4;E5RHE7;E5RH52;E5RG37;E5RFP9;Q13547;Q5TEE2 Q92769-3;Q13547 HDAC2;HDAC1 Histone deacetylase 2;Histone deacetylase 1 1 94825630.0 40234500.0 28057730.0 26533400.0 True False 52747819.13145228 23871626.052174915 23787978.294344917 1.0 0.45256138443723504 0.4509755793896076 25.652608110765378 SIRPDNMSEYSK(ub)QMQR ddPTM_RPMI8226_Bortezomib_2h_R1 4 SIRPDNMSEYSKQMQR 16 2 Q92769-3;Q92769;H3BM24;E5RJ04;E5RGV4;E5RHE7;E5RH52;E5RG37;E5RFP9;Q13547;Q5TEE2 Q92769-3;Q13547 HDAC2;HDAC1 Histone deacetylase 2;Histone deacetylase 1 1 129730800.0 44467700.0 36917300.0 48345800.0 True False 43056097.20388838 51658570.41117619 35682584.63708872 1.0 1.1997968642292762 0.8287463786630954 25.35971421734936 -6.760428554251636 1.610655565285029 1.11598915619836 0.8273520376164833 0.6928084883297083 0.08404074376134844 0.2821896196999585 1.4428819345235628 0.04116526775812946 0.09889276697270136 1.7360868428796346e-07 6.760428554251636 -0.2886371185818766 SIRPDNMSEYSK(ub)QMQR ddPTM_RPMI8226_Bortezomib_8h_R1 2 SIRPDNMSEYSKQMQR 16 2 Q92769-3;Q92769;H3BM24;E5RJ04;E5RGV4;E5RHE7;E5RH52;E5RG37;E5RFP9;Q13547;Q5TEE2 Q92769-3;Q13547 HDAC2;HDAC1 Histone deacetylase 2;Histone deacetylase 1 1 207658700.0 49830400.0 73359300.0 84469000.0 True False 75596359.8902125 60267759.756172985 67773665.12592214 1.0 0.797230975720246 0.8965202190204509 26.171813431795805 -10.113573973410864 4.569341160394289 1.0000132695271764 0.8468755973671235 0.7602606296062644 0.04053466385306089 56507099.52857742 0.9301413060216338 8106.497350506387 0.013876093593614185 7.698852985689445e-11 10.113573973410864 -0.15313767216005292 SIRPDNMSEYSK(ub)QMQR ddPTM_RPMI8226_Carfilzomib_1h_R1 3 SIRPDNMSEYSKQMQR 16 2 Q92769-3;Q92769;H3BM24;E5RJ04;E5RGV4;E5RHE7;E5RH52;E5RG37;E5RFP9;Q13547;Q5TEE2 Q92769-3;Q13547 HDAC2;HDAC1 Histone deacetylase 2;Histone deacetylase 1 1 91773230.0 37981400.0 28113530.0 25678300.0 True False 52024149.98874125 26871381.28558856 19613614.401188955 1.0 0.5165174499036294 0.3770098003606712 25.632678152484576 -13.999999999999998 0.17428633764982257 3.4667811654856475 0.25940009932180147 0.999506155325239 0.005932203563763697 12.136139702430716 0.1322760097541826 10.126674832305815 0.10944898091492562 1.0000000000000041e-14 13.999999999999998 -3.207381066163846 SIRPDNMSEYSK(ub)QMQR ddPTM_RPMI8226_Carfilzomib_2h_R1 3 SIRPDNMSEYSKQMQR 16 2 Q92769-3;Q92769;H3BM24;E5RJ04;E5RGV4;E5RHE7;E5RH52;E5RG37;E5RFP9;Q13547;Q5TEE2 Q92769-3;Q13547 HDAC2;HDAC1 Histone deacetylase 2;Histone deacetylase 1 1 124087670.0 42899300.0 58617000.0 22571370.0 True False 35672668.71122417 58301218.586436465 27290939.10877659 1.0 1.6343385760789009 0.7650377752699415 25.08831581364196 -6.711040094703564 1.7913047353227642 1.3895551575186496 0.7669983150232927 0.47014111652786106 0.26726295051386034 0.37298226317414374 2.3335836236530874 0.11869864012371414 0.30119234084905183 1.9451804914167448e-07 6.711040094703564 -0.6225568424953568 SIRPDNMSEYSK(ub)QMQR ddPTM_RPMI8226_Carfilzomib_8h_R1 4 SIRPDNMSEYSKQMQR 16 2 Q92769-3;Q92769;H3BM24;E5RJ04;E5RGV4;E5RHE7;E5RH52;E5RG37;E5RFP9;Q13547;Q5TEE2 Q92769-3;Q13547 HDAC2;HDAC1 Histone deacetylase 2;Histone deacetylase 1 1 229252200.0 56117100.0 81080300.0 92054800.0 True False 72644692.18341608 76568110.02968812 75301770.9620118 1.0 1.054008320888277 1.0365763650272897 26.114354054768782 -10.316207587255947 8.493278208185005 0.999999929469088 1.0452923429577834 0.9000110409235969 0.007116566179689552 9.505192218243005e-09 7.61627819127958e-10 0.006890596355196038 0.002296861858010058 4.828279612309659e-11 10.316207587255947 0.04529241348869539 SIRPGLSPYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIRPGLSPYR 10 1 Q14697;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 38089400.0 7997200.0 22374000.0 7718200.0 False True 12132337.073633906 18381184.891140122 6192694.3869927665 1.0 1.5150572210103084 0.5104288109873555 23.532354150347963 -6.767324361867271 1.5846123739520606 1.2964191171410697 0.5053254395373277 0.7203100899436756 0.2169275981511874 0.27074735234066855 1.3412661338435603 0.1079309174568587 0.25756488956695944 1.7087386314015886e-07 6.767324361867271 -0.791093677603742 SIRPGLSPYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIRPGLSPYR 10 1 Q14697;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 6937300.0 1747000.0 2741600.0 2448700.0 False True 1452707.9052224301 2726830.456635005 2960711.848490423 1.0 1.8770672664698473 2.0380641131274744 20.470313219955028 -10.904032641018201 0.32320628154304776 8.331577378718528e-16 2.0758955768752445 0.9992597598841304 0.012410927054423688 2.683571480561255 0.162034301063624 2.0824605360228885 0.05272638916768641 1.2472897660152985e-11 10.904032641018201 2.0758955768752436 SIRPGLSPYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIRPGLSPYR 10 1 Q14697;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 24014100.0 7997200.0 6331500.0 9685400.0 False True 10352533.048379444 5979146.459164188 7922756.580596225 1.0 0.5775539601006294 0.7652964297309277 23.303480472440413 -10.05581748334456 4.854252189839268 1.0000074758079798 0.6714251950398745 0.8033031987267197 0.07664554229073371 106237065.45847736 4.492109010761703 10184.680886230935 0.02623780777548647 8.793920125848433e-11 10.05581748334456 -0.32858228076810525 SISFHPSGDFILVGTQHPTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SISFHPSGDFILVGTQHPTLR 21 0 Q05048;A0A0A0MSZ9 Q05048 CSTF1 Cleavage stimulation factor subunit 1 0 19194200.0 7421000.0 3792700.0 7980500.0 False True 7185424.41705002 5307144.888669218 5890167.640131863 1.0 0.7385986659432525 0.8197383060846495 22.77664194330528 -10.303496529311696 7.892241159477573 1.0000007032142955 0.7791684860139511 0.9080570438881364 0.033125119376578346 4.0988462449219915e-07 3.615263491014361e-08 0.03207336119341231 0.010691086307218375 4.9716834685763074e-11 10.303496529311696 -0.2208322172003444 SISFHPSGDFILVGTQHPTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SISFHPSGDFILVGTQHPTLR 21 0 Q05048;A0A0A0MSZ9 Q05048 CSTF1 Cleavage stimulation factor subunit 1 0 14836800.0 7421000.0 3994100.0 3421700.0 False True 6170890.306042152 3972582.9905332224 4137161.6498467284 1.0 0.6437617253775385 0.67043188983539 22.557047218739555 -10.758889670512513 6.937294516560647 1.0072864860339963 0.6570968076066713 0.9954834816998159 0.01088804904630797 0.0012363786581383843 4.297110698295242e-05 0.010622505963748814 0.0035141027190866946 1.7422494235039948e-11 10.758889670512513 -0.35018967842732496 SISLASCHQLHSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SISLASCHQLHSK 13 0 O75691 O75691 UTP20 Small subunit processome component 20 homolog 0 2586630.0 996840.0 761120.0 828670.0 False True 1306866.8934122908 647563.862822523 742927.1775639317 1.0 0.49550865974705605 0.568479606690559 20.317680777027476 -10.630994432311546 6.568830553627925 1.001763259570562 0.5319941332188899 0.9820934684566699 0.029790264343214322 0.0007716213962999825 4.334594388831708e-05 0.028932352123937393 0.009614766473365474 2.3388672229237273e-11 10.630994432311546 -0.469769126351672 SISLLCLEGLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SISLLCLEGLQK 12 0 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 0 6261200.0 2428700.0 2459500.0 1373000.0 False True 3184049.2195642577 2092552.1870559088 1230935.1307459895 1.0 0.6571984422220326 0.3865942533747782 21.602431206798837 -7.59941999203407 0.2011148651402486 1.206741046369929 6.019259963410863e-13 0.9999309738002156 0.0020853451477313924 0.13246402768820748 0.02195477761565618 0.03958125886703481 0.07443065027877303 2.5152433413969537e-08 7.59941999203407 -1.206741046369327 down SISLLCLEGLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SISLLCLEGLQK 12 0 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 0 6198400.0 2428700.0 1330200.0 2439500.0 False True 3326656.0231496426 1271427.3656168366 1863340.3430795826 1.0 0.3821938176863452 0.5601241397105409 21.66564126832173 -10.89462275151547 11.317429245733392 1.0339410740644277 0.47115897869844303 0.9217434022537714 0.07263974978806252 0.03714946594773528 0.0003459002667263974 0.04200129787901315 0.023444378433486655 1.274609785910542e-11 10.89462275151547 -0.5627820953659847 SISLYYTGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SISLYYTGEK 10 0 P19338;H7BY16 P19338 NCL Nucleolin 0 463109100.0 121110000.0 127320000.0 214679100.0 False True 158776382.8309082 108324352.28947291 192466166.07933816 1.0 0.6822447416807252 1.2121838440185937 27.242421094081987 -6.744319913331091 1.67085957158933 0.8118899598448375 1.212798298714482 0.624191132960696 0.13350194970727494 0.3100517019140811 1.7011513585196012 0.06316808589226108 0.15428114414958302 1.8016900771641044e-07 6.744319913331091 0.4009083388696446 SISLYYTGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SISLYYTGEK 10 0 P19338;H7BY16 P19338 NCL Nucleolin 0 343969000.0 110960000.0 57329000.0 175680000.0 False True 107437635.53643319 80220768.66678543 129664137.71297096 1.0 0.7466728792591657 1.2068781769587673 26.678924218814956 -6.7572055880674124 1.6225796604480875 0.8523522653448573 1.2083575991520916 0.6796860549583207 0.10651236442593569 0.28760127812358754 1.4916086643718556 0.05180598682595576 0.12486419456508169 1.7490185351987635e-07 6.7572055880674124 0.3560053338072343 SISLYYTGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SISLYYTGEK 10 0 P19338;H7BY16 P19338 NCL Nucleolin 0 388934100.0 156614100.0 232320000.0 0.0 False True 237595039.72437984 190860680.87555528 0.0 1.0 0.8033024641295611 0.0 27.823929476383462 -7.245587763046945 0.8563827496988315 0.9893646492658786 1.3075801072577978e-16 0.9888701344617078 0.045634445757491225 0.09790509890498117 0.1383048774369341 0.03865118686609002 0.06803708007501433 5.680835805596761e-08 7.245587763046945 -0.9893646492658785 down SISLYYTGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SISLYYTGEK 10 0 P19338;H7BY16 P19338 NCL Nucleolin 0 356320000.0 121110000.0 103140000.0 132070000.0 False True 165887639.87468717 98582933.7616302 100877786.06703013 1.0 0.5942753410447007 0.6081091161658216 27.30563115560488 -10.028086005993693 5.851441484061214 1.0000008197203467 0.6011922286166732 0.9990983786865703 0.005647615044080191 6.039340102214256e-08 1.0033298529965798e-08 0.005468290956122266 0.0018227599175937956 9.373763541683035e-11 10.028086005993693 -0.3988085911036735 SISLYYTGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SISLYYTGEK 10 0 P19338;H7BY16 P19338 NCL Nucleolin 0 224860000.0 110960000.0 71839600.0 42060400.0 False True 92268156.3614658 71452585.81575592 50855035.17468317 1.0 0.774401360484936 0.5511656153121306 26.459329494249232 -6.971255110004066 0.22621044723861738 1.0952041032507251 0.2240131607813169 0.999990584866838 0.0005622155281414038 0.07589753261390046 0.007556531513364744 0.00589961304087995 0.022338202313707638 1.0684270874359248e-07 6.971255110004066 -0.8711909424694082 SISLYYTGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SISLYYTGEK 10 0 P19338;H7BY16 P19338 NCL Nucleolin 0 609689100.0 156614100.0 271870000.0 181205000.0 False True 202740039.77544707 256740195.50706324 148227549.32031086 1.0 1.2663517072968231 0.7311212402073427 27.59505579847591 -6.771405360174119 1.5691254443522276 1.1524992878674267 0.727953718106522 0.7358787272577361 0.11229709082549637 0.2641687640251277 1.283836172682546 0.05640450858357361 0.13409097577962878 1.6927570835266014e-07 6.771405360174119 -0.42454556976090474 SISLYYTGEK(ub)GQNQDYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SISLYYTGEKGQNQDYR 17 1 P19338;H7BY16 P19338 NCL Nucleolin 1 50708000.0 14257000.0 25001000.0 11450000.0 True False 18691065.064984377 21270948.253134698 10265263.836155538 1.0 1.1380276179650908 0.5492070034781679 24.15584544411278 -6.844935112874936 1.259239761508682 1.0734533448093737 0.527865851774801 0.9326060406785324 0.06527337601491282 0.16312311820808373 0.5003015820199245 0.040607927893128885 0.09371669320049833 1.4291074628302265e-07 6.844935112874936 -0.5455874930345727 SISLYYTGEK(ub)GQNQDYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SISLYYTGEKGQNQDYR 17 1 P19338;H7BY16 P19338 NCL Nucleolin 1 74907000.0 18595000.0 23428000.0 32884000.0 True False 18004711.90338839 32782922.575406022 24270693.901146077 1.0 1.8207968420331377 1.3480190092116089 24.10187117910334 -10.101736213611394 4.949149541471435 0.9999790555700876 1.5844079256251056 0.6707610964691951 0.19301074202805826 4.460677668088489e-05 8.09632995914332e-06 0.18688853675462266 0.06229394912479931 7.911590246503839e-11 10.101736213611394 0.584428870055018 SISLYYTGEK(ub)GQNQDYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SISLYYTGEKGQNQDYR 17 1 P19338;H7BY16 P19338 NCL Nucleolin 1 176195200.0 44321300.0 29730000.0 102143900.0 True False 67238652.4210537 24424449.218449764 81955113.39373828 1.0 0.36325012978401106 1.218869064783288 26.002787474970255 -6.707432174452727 1.8042076928154689 0.607517798174048 1.2167224987996152 0.45293714799258056 0.26843352129610915 0.38027632600157163 2.4113354915726593 0.11846763782636777 0.30192132473661815 1.9614074725927328e-07 6.707432174452727 0.6092047006255672 SISLYYTGEK(ub)GQNQDYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SISLYYTGEKGQNQDYR 17 1 P19338;H7BY16 P19338 NCL Nucleolin 1 65210000.0 14257000.0 27423000.0 23530000.0 True False 19528198.18093811 26211361.184265926 17972698.61556159 1.0 1.3422314205030648 0.9203459760616892 24.219055505635673 -6.690939071827338 1.8631375946830058 1.2143707109845703 0.9217903336697101 0.374778147060151 0.14471270447511284 0.4146645938825434 2.791520487831344 0.06212010901606485 0.16157037942954114 2.0373278790757016e-07 6.690939071827338 -0.2925803773148602 SISLYYTGEK(ub)GQNQDYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SISLYYTGEKGQNQDYR 17 1 P19338;H7BY16 P19338 NCL Nucleolin 1 76385000.0 18595000.0 35313000.0 22477000.0 True False 15462566.39817463 35122761.85991834 27176836.77809419 1.0 2.2714703986050218 1.7575890106640022 23.882276454537617 -10.465537399355611 5.55408336727709 0.9989090258389076 2.0145297046344957 0.8386284104559318 0.20979119812812677 0.0028365982017046552 0.00027296216159677434 0.20330795910182664 0.06770981804426009 3.423439053435958e-11 10.465537399355611 1.015620678795588 SISLYYTGEK(ub)GQNQDYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SISLYYTGEKGQNQDYR 17 1 P19338;H7BY16 P19338 NCL Nucleolin 1 115830300.0 44321300.0 22292000.0 49217000.0 True False 57374796.5534362 21051430.603757095 40260011.00906559 1.0 0.366910766893104 0.7017020264563257 25.773913797062704 -10.62117406594902 6.693261725801834 1.001356810348948 0.5343063966748207 0.7206571121401555 0.1366779593789287 0.002774153751156761 0.0001570114956459772 0.13266530135640325 0.04411262170568371 2.3923567036865224e-11 10.62117406594902 -0.46705041367412736 SISTSTK(ub)MVNGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SISTSTKMVNGR 12 1 O75190;A0A0J9YX62;O75190-3;C9J2C4;O75190-4;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 15990860.0 4509500.0 5026360.0 6455000.0 True False 5911998.170060125 4276446.680597829 5787098.520732238 1.0 0.7233504743379068 0.9788735304485696 22.495214392251135 -10.443816107581364 8.042118270737904 1.0000050114459305 0.8511120025248965 0.31162041891555603 0.10431685083127985 9.373549870252604e-06 6.483311360987513e-07 0.10100775571002958 0.033668118833195856 3.5990169533081597e-11 10.443816107581364 -0.14889300892103396 SISTSTK(ub)MVNGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SISTSTKMVNGR 12 1 O75190;A0A0J9YX62;O75190-3;C9J2C4;O75190-4;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 30721270.0 4777470.0 8426500.0 17517300.0 True False 4625811.829904866 11791245.393616997 12928993.622264482 1.0 2.5490110335637004 2.7949674776395685 22.14127515013085 -10.343812389457721 0.39461529852243066 2.674102262908506e-13 2.8204919067924656 0.9991672059792507 0.022929361123385634 1.7535624655461697 0.18407209063207913 1.90769965990111 0.06353786490329161 4.530932690487874e-11 10.343812389457721 2.8204919067921983 SISTSTK(ub)MVNGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SISTSTKMVNGR 12 1 O75190;A0A0J9YX62;O75190-3;C9J2C4;O75190-4;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 36841100.0 8206200.0 9021500.0 19613400.0 True False 12449405.353580581 7411542.839698773 15736802.893141413 1.0 0.5953330805127278 1.2640606074100833 23.5695734977556 -6.7428603638257405 1.67602550569327 0.760029573114309 1.264718390357606 0.6178036662652824 0.17001742835763 0.3126623708671909 1.725541437979938 0.08021171545273764 0.196232853378784 1.807755269598638e-07 6.7428603638257405 0.5046888172432971 SISTSTK(ub)MVNGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SISTSTKMVNGR 12 1 O75190;A0A0J9YX62;O75190-3;C9J2C4;O75190-4;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 16617200.0 4509500.0 4081500.0 8026200.0 True False 6176784.014655297 3901165.8342844113 6130576.8647777615 1.0 0.6315852756107938 0.9925192220145788 22.558424453774027 -10.816783713728844 10.03434044395181 1.0027263555216024 0.8120522490262272 0.2655380872539522 0.14735066658972076 0.009081647740557034 0.00016582079938280502 0.1441706328907334 0.04755722314621251 1.524811947836617e-11 10.816783713728844 -0.1906741064953752 SISTSTK(ub)MVNGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SISTSTKMVNGR 12 1 O75190;A0A0J9YX62;O75190-3;C9J2C4;O75190-4;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 23632070.0 4777470.0 12342500.0 6512100.0 True False 3972677.982806529 12276008.502705574 7873750.001451576 1.0 3.09010912936696 1.9819753917958145 21.921680425565125 -10.334098793897201 10.612825068863383 0.9999998683837876 2.5360422605813873 0.7192502813538558 0.45239370396875106 1.4084928081235837e-06 8.917833891140425e-08 0.4380283595082555 0.1460094401166718 4.6334150619329e-11 10.334098793897201 1.5360423921975996 SISTSTK(ub)MVNGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SISTSTKMVNGR 12 1 O75190;A0A0J9YX62;O75190-3;C9J2C4;O75190-4;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 31067300.0 8206200.0 7829300.0 15031800.0 True False 10623087.668385366 7393592.572492173 12296166.639292782 1.0 0.6959928039091432 1.1574946026178952 23.340699819848048 -6.729019724642347 1.7266233680691918 0.8168520180430209 1.1571803050107914 0.5547871114660891 0.12780768070937934 0.3380831293447253 1.974088657142097 0.058667902133091795 0.14575232637147414 1.8662949261474894e-07 6.729019724642347 0.3403282869677705 SITCWTLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SITCWTLSR 9 0 Q92973-2;Q92973;Q92973-3 Q92973-2 TNPO1 Transportin-1 0 17200500.0 4618000.0 4446300.0 8136200.0 False True 6054242.720775609 3782929.3715416524 7294344.071941383 1.0 0.6248393970992001 1.204831786295959 22.529515084767073 -6.732154984174448 1.7161215420950082 0.7747636447143227 1.2045760815623416 0.5689116734183575 0.15768280664331275 0.3322068122653603 1.9178265768405656 0.0727967273577163 0.1801494667827968 1.8528702822541898e-07 6.732154984174448 0.42981243684801895 SITCWTLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SITCWTLSR 9 0 Q92973-2;Q92973;Q92973-3 Q92973-2 TNPO1 Transportin-1 0 13148300.0 4618000.0 4272900.0 4257400.0 False True 6325399.396757537 4084109.149409246 3251889.8039053134 1.0 0.6456681852378842 0.5141003120802561 22.592725146289965 -13.999999999999998 0.13760283585397448 2.689344073070683 0.3464781229092035 0.9996126613216382 0.004038501219605223 11.93231322127007 0.11604029587508372 5.420327192368849 0.14962372967814616 1.0000000000000041e-14 13.999999999999998 -2.3428659501614795 SITHDIEEK(ub)GVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SITHDIEEKGVR 12 1 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4;K7EL40;K7EK18;K7EQD7;K7ER52;K7EIE4;K7ELJ9;K7EJZ2;K7ENQ5;K7EN52;K7EKN4;K7EIR4 Q9UHD8 SEPT9 Septin-9 1 6093100.0 1473600.0 1726600.0 2892900.0 True False 1426821.3746078585 2416040.384100053 2135162.7048602765 1.0 1.6933026285536739 1.496447097624323 20.444373302807964 -10.272636081799668 5.092119805623413 0.9998823474338597 1.5948748630891851 0.9241028315419484 0.08036593397091359 0.00010736400085067162 1.5335936318782224e-05 0.07782921986410506 0.025937993655886164 5.337819921590675e-11 10.272636081799668 0.5949925156553254 SITHDIEEK(ub)GVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SITHDIEEKGVR 12 1 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4;K7EL40;K7EK18;K7EQD7;K7ER52;K7EIE4;K7ELJ9;K7EJZ2;K7ENQ5;K7EN52;K7EKN4;K7EIR4 Q9UHD8 SEPT9 Septin-9 1 5579900.0 1473600.0 2911800.0 1194500.0 True False 1225363.6915488106 2896113.555452953 1444264.4272560184 1.0 2.363472637084898 1.178641441081485 20.22477857824224 -6.612240865383664 2.1466905365241313 1.9096060035228277 1.183051383948537 0.05713560635860515 0.5875131420619821 0.6063647062325287 5.298967197829875 0.22582194774216285 0.6515639612374202 2.442075769967421e-07 6.612240865383664 -0.7265546195742907 SITHDIEEK(ub)GVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SITHDIEEKGVR 12 1 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4;K7EL40;K7EK18;K7EQD7;K7ER52;K7EIE4;K7ELJ9;K7EJZ2;K7ENQ5;K7EN52;K7EKN4;K7EIR4 Q9UHD8 SEPT9 Septin-9 1 21447900.0 4176000.0 5385900.0 11886000.0 True False 5405914.321266512 5086169.930413398 9722869.960658992 1.0 0.9408528563622881 1.7985616091638483 22.366107215998216 -6.890374583478555 1.0201898449217426 0.9543271329978673 1.8728691100104735 0.9811360482196495 0.05372055599212201 0.11883872738082209 0.22008923510487408 0.040103236696230865 0.10011134166390563 1.2871389021844752e-07 6.890374583478555 0.9185419770126062 SITHSTVGSK(ub)GEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SITHSTVGSKGEK 13 1 A0A1B0GU48;A0A1B0GV09;Q9H9B1-3;Q9H9B1;A0A1W2PPZ7;Q9H9B1-4;A0A1B0GW12;A0A0D9SER9;A0A0D9SEQ1;A0A1B0GVZ8;A0A1B0GUD1 A0A1B0GU48 EHMT1 Histone-lysine N-methyltransferase EHMT1 1 3829970.0 1151400.0 968070.0 1710500.0 True False 1114849.4372444963 1354625.3994183568 1262468.7360999365 1.0 1.2150747483592939 1.1324118700909978 20.088417453633166 -10.146314188875191 4.440974696323887 0.9999718998612537 1.1737433091729956 0.8548674214690098 0.033746978758707635 9.390681940217266e-06 1.8051206150716618e-06 0.03268065362396625 0.010891790556853399 7.13979613052807e-11 10.146314188875191 0.17377140931174195 SITHSTVGSK(ub)GEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SITHSTVGSKGEK 13 1 A0A1B0GU48;A0A1B0GV09;Q9H9B1-3;Q9H9B1;A0A1W2PPZ7;Q9H9B1-4;A0A1B0GW12;A0A0D9SER9;A0A0D9SEQ1;A0A1B0GVZ8;A0A1B0GUD1 A0A1B0GU48 EHMT1 Histone-lysine N-methyltransferase EHMT1 1 3854900.0 1151400.0 1223600.0 1479900.0 True False 957440.1156686358 1217008.2239344155 1789340.2477155128 1.0 1.2711063637484088 1.8688795449790747 19.868822729067443 -6.958093360051571 0.46152515026035024 0.9828388252486902 2.18130598693798 0.999692800822498 0.0063619641727162566 0.08038944581854657 0.02370253647286939 0.008139684233363899 0.04937402253833675 1.1013025376778109e-07 6.958093360051571 1.1984671616892897 SITILSTPEGTSAACK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SITILSTPEGTSAACK 16 0 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 0 13611100.0 3383800.0 4295600.0 5931700.0 False True 4436194.568765812 3654713.2241176562 5317944.584884186 1.0 0.8238397048338729 1.1987627013311288 22.080891211928783 -6.778951607095737 1.540092746845087 0.9001172950197861 1.201628342692518 0.7636140081921846 0.07446294773025695 0.2522084893446379 1.1815317763536473 0.038085102845563476 0.0899387855150321 1.6635980127395325e-07 6.778951607095737 0.30151104767273196 SITILSTPEGTSAACK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SITILSTPEGTSAACK 16 0 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 0 12111700.0 3383800.0 5056100.0 3671800.0 False True 4634882.303756639 4832704.7837131955 2804596.4630947346 1.0 1.04268123050206 0.6051062959725144 22.144101273451675 -6.8829451526707235 1.0632701282095554 1.0276393829617823 0.5722937603975634 0.9759831198549007 0.030527808806913585 0.12505179042871536 0.25681009953057365 0.02205555655510921 0.05375684233285361 1.3093472708667065e-07 6.8829451526707235 -0.45534562256421884 SITQIK(ub)YNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SITQIKYNR 9 1 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 92622600.0 3624400.0 7569200.0 81429000.0 True False 5498479.7791325385 6218417.121570474 65334522.45840147 1.0 1.1309338892488416 11.88228839293993 22.390601366458036 -6.909556907062522 0.8987331905811836 0.6624331806146908 13.258696135120099 0.9907536039390639 0.4903469874918872 0.10471211938176724 0.14035679597127051 0.40057615017880616 1.1024253923110465 1.2315246043641564e-07 6.909556907062522 12.596262954505407 up SITQIK(ub)YNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SITQIKYNR 9 1 Q13347;Q5TFK1 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 88710500.0 3624400.0 7963100.0 77123000.0 True False 4691857.247604969 7519946.484872515 63087405.34880567 1.0 1.6027654056847507 13.446147659545613 22.161727688550485 -6.917461735026403 0.8433350253482914 0.7140210820790646 15.24879896991976 0.993446366101622 0.46390040395021664 0.09968843939708417 0.11352211999140016 0.3944157216230369 1.1542610440124652 1.2093117287198252e-07 6.917461735026403 14.534777887840695 up SITSNNDDEDLTPEQK(ub)AER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SITSNNDDEDLTPEQKAER 19 1 P15884-6;H3BPJ7;P15884-16;P15884-8;P15884-9;P15884-15;P15884-7;P15884-5;P15884-10;P15884-14;P15884-12;P15884 P15884-6 TCF4 Transcription factor 4 1 14529800.0 2515100.0 1918700.0 10096000.0 True False 2435259.527196137 2684846.9158883207 7451554.726492234 1.0 1.1024890308013902 3.0598606198952703 21.215644098776398 -6.917743315319918 0.8412898082343085 0.9532000020698266 3.3596867895282343 0.9935308338857067 0.07623219603266447 0.09951796689234502 0.11262754363355373 0.06490870853150826 0.19043012094277836 1.2085279103664186e-07 6.917743315319918 2.406486787458408 up SITSNNDDEDLTPEQK(ub)AER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SITSNNDDEDLTPEQKAER 19 1 P15884-6;H3BPJ7;P15884-16;P15884-8;P15884-9;P15884-15;P15884-7;P15884-5;P15884-10;P15884-14;P15884-12;P15884 P15884-6 TCF4 Transcription factor 4 1 11520700.0 2515100.0 4547400.0 4458200.0 True False 2091417.0878219432 4522902.25361177 5390389.007612203 1.0 2.162601749764816 2.5773859451563994 20.996049374210674 -9.997676833715 0.2531534914087521 6.016626650275889e-15 2.8030543591980135 0.9990861361380314 0.020183246322312894 1.4540336392873159 0.11434276859221575 1.2148228591777124 0.1828673511437411 1.005363621043439e-10 9.997676833715 2.8030543591980073 SITSNNDDEDLTPEQK(ub)AER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SITSNNDDEDLTPEQKAER 19 1 P15884-6;H3BPJ7;P15884-16;P15884-8;P15884-9;P15884-15;P15884-7;P15884-5;P15884-10;P15884-14;P15884-12;P15884 P15884-6 TCF4 Transcription factor 4 1 16700400.0 5488600.0 7245400.0 3966400.0 True False 7105100.896480699 6842187.120781528 3244555.89870081 1.0 0.962996475415374 0.45665162901597983 22.76042370602922 -6.921587269375533 0.8128697353954372 1.010545986527108 0.37194211620508927 0.9946105228661375 0.018197321406665544 0.09724694149471462 0.1008414044393682 0.015812065764583567 0.0481077086456619 1.1978783911350997e-07 6.921587269375533 -0.6386038703220187 down SITVLVEGENTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SITVLVEGENTR 12 0 P33993;P33993-3;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 14201600.0 4586400.0 3947900.0 5667300.0 False True 4440807.242468433 5524317.058026524 4182864.1146443575 1.0 1.2439893821997596 0.9419152614062353 22.08239052041524 -6.691777089707597 1.8601265935526174 1.152709773243858 0.9429367520697983 0.37876614986790635 0.1031532455875146 0.41284828254808714 2.7709498044021585 0.044340875559991375 0.11520767454924344 2.0334004264032206e-07 6.691777089707597 -0.20977302117405972 SITVLVEGENTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SITVLVEGENTR 12 0 P33993;P33993-3;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 41690000.0 10800000.0 19285000.0 11605000.0 False True 16384389.585760785 15843441.07560726 9311266.663347812 1.0 0.9669839082303288 0.5683011023761284 23.965818589274075 -6.923304492578384 0.7998450211915661 1.0077939091078154 0.49885742136835676 0.9950504664617694 0.013802286124003478 0.09626651028115499 0.09582639760420504 0.012105090310355298 0.03748928535568256 1.1931512688340146e-07 6.923304492578384 -0.5089364877394587 SITVLVEGENTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SITVLVEGENTR 12 0 P33993;P33993-3;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 10574600.0 4586400.0 3584500.0 2403700.0 False True 3813794.811970322 3565189.587032455 2906302.5565469163 1.0 0.9348142107284922 0.7620500577075966 21.862795795849518 -6.954198433475506 0.5106765726839754 1.003161972602516 0.6861141226151322 0.9994909000728086 0.0022652844787323257 0.08184238871389116 0.029314675248855927 0.002606127489272933 0.01425929062050983 1.1112238820082185e-07 6.954198433475506 -0.3170478499873839 SITVLVEGENTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SITVLVEGENTR 12 0 P33993;P33993-3;P33993-2;C9J8M6 P33993 MCM7 DNA replication licensing factor MCM7 0 35761000.0 10800000.0 14839000.0 10122000.0 False True 13980812.899827184 14013196.605470654 8279899.860490516 1.0 1.0023162963323735 0.5922330782777919 23.736944911366525 -6.905626684264885 0.9249891891055863 1.014518992180874 0.5439076671598633 0.9891642510359951 0.020066524270706942 0.10738191705150536 0.15497457412946264 0.016081459654685784 0.043156315197954306 1.242720079905528e-07 6.905626684264885 -0.47061132502101066 SIVEK(ub)IQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIVEKIQAK 9 1 O95197-3;O95197-4;O95197-7;O95197-2;O95197 O95197-3 RTN3 Reticulon-3 1 6655100.0 2200700.0 2111900.0 2342500.0 True False 2885139.0116091142 1796812.752121722 2100120.570846669 1.0 0.622782037500368 0.7279096648016897 21.460209401722675 -10.227343933411657 7.907735611925857 1.0000002520351208 0.67534585115103 0.9270918862796069 0.042918174126286734 1.906893392028809e-07 1.8636848689831025e-08 0.04155537560890869 0.013851781136728216 5.924559515829834e-11 10.227343933411657 -0.3246544008840908 SIVEK(ub)IQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIVEKIQAK 9 1 O95197-3;O95197-4;O95197-7;O95197-2;O95197 O95197-3 RTN3 Reticulon-3 1 9472100.0 1397700.0 1323100.0 6751300.0 True False 1353330.7785622983 1851420.7298753492 4982931.995341423 1.0 1.368047456839926 3.681976405380366 20.36808307254624 -6.934855000413771 0.7058121857599198 0.9703381350590142 4.221608712460173 0.9974092115857891 0.06042281847356419 0.09019429664474637 0.06589928246470968 0.05673471578839405 0.204071975367571 1.1618364559437065e-07 6.934855000413771 3.251270577401159 up SIVEK(ub)IQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIVEKIQAK 9 1 O95197-3;O95197-4;O95197-7;O95197-2;O95197 O95197-3 RTN3 Reticulon-3 1 7085160.0 2200700.0 857660.0 4026800.0 True False 3014358.261681316 819765.7452976519 3075752.774549235 1.0 0.27195365452028647 1.0203673576722347 21.523419463245567 -10.955768257568248 13.089145626828984 1.0932933265652791 0.6461605061345036 0.22960499989555616 0.3055386148715119 0.11830995659613805 0.0003998005670946212 0.04207683815965745 0.09861216391838724 1.1072144433844952e-11 10.955768257568248 -0.4471328204307755 SIVEK(ub)IQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIVEKIQAK 9 1 O95197-3;O95197-4;O95197-7;O95197-2;O95197 O95197-3 RTN3 Reticulon-3 1 6773900.0 1397700.0 1967000.0 3409200.0 True False 1162249.4786086942 1956403.3805810672 4122047.957640197 1.0 1.6832903921136098 3.5466120084429886 20.148488347980518 -6.953573728724404 0.5181263716681638 0.9678726202827178 4.344917892000609 0.9994527192966866 0.025176931191296176 0.08208165146003439 0.030263031545728545 0.028608064612049403 0.15388385552494593 1.1128234564413938e-07 6.953573728724404 3.377045271717891 SIVFHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIVFHR 6 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 71288000.0 19947000.0 25044000.0 26297000.0 False True 26150710.16702279 21307532.820747416 23576038.69863602 1.0 0.814797482923319 0.9015448738507474 24.64034679005393 -10.060633013701572 4.436561700223015 1.0000093659696376 0.8581711783942998 0.7809007188028361 0.03541447409042758 49110899.48244168 0.27337429174204203 4837.750338089816 0.012123316444685606 8.696950261076245e-11 10.060633013701572 -0.14183818757533784 SIVFHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIVFHR 6 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 71732000.0 21907000.0 16594000.0 33231000.0 False True 21211574.276285544 23220070.736566816 24526804.19136919 1.0 1.0946887031636667 1.1562934401710137 24.33834836269935 SIVFHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIVFHR 6 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 94577000.0 25261000.0 51672000.0 17644000.0 False True 38322783.82647256 42450727.88482129 14156655.666360063 1.0 1.107715140868687 0.36940572298876023 25.19169902869824 -6.869837502203403 1.1348973921710912 1.0608657791567575 0.3262893140104501 0.9645237112055935 0.06133413429572439 0.13701378437328643 0.3299217445254924 0.041944896022119246 0.09928264836916538 1.3494677117329435e-07 6.869837502203403 -0.7345764651463074 down SIVFHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIVFHR 6 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 74889000.0 19947000.0 22166000.0 32776000.0 False True 27321944.9474064 21186632.82684015 25034983.84290892 1.0 0.775443800491639 0.9162958160958239 24.70355685157682 -10.42342187580553 5.386127757457943 1.0001208827355734 0.8458698082937298 0.6148765882560325 0.057502594578803426 8.353522549642219e-05 8.942261848046016e-06 0.05572018972622777 0.01855888259728441 3.772055935196943e-11 10.42342187580553 -0.1542510744418436 SIVFHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIVFHR 6 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 49702700.0 21907000.0 18770000.0 9025700.0 False True 18216641.144652426 18668882.284446694 10912932.139878312 1.0 1.0248257149165518 0.5990639027920825 24.118753638133626 -6.893062804777715 1.0040646394496864 1.0212253585609516 0.5601658290718493 0.9827881444505145 0.025598298474928945 0.11669417156516668 0.20760203725636703 0.019342906982552154 0.04878660361216148 1.2791963019249004e-07 6.893062804777715 -0.46105952948910234 SIVFHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIVFHR 6 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 63571000.0 25261000.0 16109000.0 22201000.0 False True 32700862.46875323 15212519.989050925 18160645.801496737 1.0 0.4652024087617566 0.5553567835970639 24.962825350790688 -10.815153843786131 7.29870941189609 1.0219184489792432 0.5102795961794104 0.9752122205474626 0.0368053694043525 0.012076355352866431 0.00030584376523977804 0.032784137522444974 0.011878881896172424 1.5305451877489816e-11 10.815153843786131 -0.5116388527998328 SIVTSQK(ub)GSTNAAPQER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIVTSQKGSTNAAPQER 17 1 Q9UK61-3;Q9UK61-4;Q9UK61;Q9UK61-2 Q9UK61-3 FAM208A Protein FAM208A 1 8379000.0 1488700.0 1435300.0 5455000.0 True False 1927151.4966641415 1355424.2932698987 4462245.973026657 1.0 0.7033304312692124 2.3154619555082774 20.878038558132182 -6.859213967604508 1.1897929835727128 0.8393743650889277 2.3923280700939222 0.9526654453900109 0.15242362648860422 0.14761683262829303 0.39753990800277095 0.09995348009788 0.2331045560617981 1.3828848932928157e-07 6.859213967604508 1.5529537050049944 up SIYGEK(ub)FEDENFILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIYGEKFEDENFILK 15 1 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 97688900.0 48521200.0 47979700.0 1188000.0 True False 63611763.07996914 40821315.783405796 1065077.1561006797 1.0 0.641725897961475 0.016743399404945347 25.922790237393265 -7.5440284037523515 0.6667199979916513 0.996677955725427 1.1028618040020606e-18 0.9892200275457418 0.04218533080837343 0.11893751360406976 0.13086063966951464 0.03826275834574431 0.0752355593615616 2.857403657187499e-08 7.5440284037523515 -0.996677955725427 down SIYGEK(ub)FEDENFILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIYGEKFEDENFILK 15 1 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 236058300.0 95255100.0 83024400.0 57778800.0 True False 92231278.99050549 116176475.88652635 42644798.9531547 1.0 1.2596212169895837 0.46236807534182256 26.45875276835506 -6.81899673929533 1.3760746176458536 1.140080840111697 0.44531524650233567 0.8820904475570797 0.11400477693046761 0.19478692464469965 0.7250095480897321 0.06510642466865485 0.15011133979721003 1.5170617575920545e-07 6.81899673929533 -0.6947655936093614 down SIYGEK(ub)FEDENFILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIYGEKFEDENFILK 15 1 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 400018000.0 115918000.0 90163000.0 193937000.0 True False 175856080.74094632 74072708.20326559 155605266.94439313 1.0 0.421212095090315 0.8848443925781294 27.389819980346658 -10.008859133468462 7.050195297128168 1.0000000356908962 0.6530282438342327 0.4275107030865557 0.18927709285323438 1.0613751659189445e-07 1.4719272582319198e-08 0.18326677622593382 0.06108891903659414 9.798077415443703e-11 10.008859133468462 -0.3469717918566635 SIYGEK(ub)FEDENFILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIYGEKFEDENFILK 15 1 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 87831600.0 48521200.0 3602000.0 35708400.0 True False 66460798.87612641 3442851.7297788616 27274811.357582685 1.0 0.0518027436925014 0.41038945993440584 25.986000298916156 -10.59136433881581 6.406354732434803 1.001853561758657 0.23109610181345375 0.8597569832999338 0.14639241388880783 0.0038820253138521126 0.00024761837383686377 0.1419790103863261 0.047247948416871334 2.562333538857066e-11 10.59136433881581 -0.7707574599452033 SIYGEK(ub)FEDENFILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIYGEKFEDENFILK 15 1 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 221671700.0 95255100.0 88604900.0 37811700.0 True False 79208836.16642983 88127567.81700437 45717951.64845233 1.0 1.1125976858419548 0.5771824692941069 26.239158043789335 -6.851785547905564 1.2264850979834276 1.0601880382898823 0.5550344675074493 0.942862311121504 0.055094672268119364 0.15549951787888283 0.44923559654517203 0.035134427886281516 0.0813992720164281 1.4067419936847682e-07 6.851785547905564 -0.505153570782433 SIYGEK(ub)FEDENFILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIYGEKFEDENFILK 15 1 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 466465000.0 115918000.0 101246000.0 249301000.0 True False 150058136.08538604 95611571.09761307 203930776.04427457 1.0 0.6371635260297263 1.3590117894589464 27.160946302439108 -6.770033418260226 1.5741968700098337 0.7918956572571753 1.363089470615427 0.7307326578726343 0.15291995600653027 0.266376240737507 1.302723844263842 0.0765672329443711 0.1822657602773935 1.6981129803781113e-07 6.770033418260226 0.5711938133582518 SIYGEKFEDENFILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIYGEKFEDENFILK 15 1 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 73025100.0 14505000.0 25213600.0 33306500.0 False True 19016195.466619805 21451829.161843035 29860262.87850787 1.0 1.1280820708589494 1.5702543093292907 24.18072530207832 -6.948259930134612 0.5776409888942128 0.9946665007056479 1.7254515946300912 0.9990574844209128 0.007499892235458662 0.08419228467384184 0.03891431528548313 0.00787813277908401 0.03691363126838476 1.1265230176630883e-07 6.948259930134612 0.7307850939244434 SIYGEKFEDENFILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIYGEKFEDENFILK 15 1 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 51456000.0 20263000.0 7950800.0 23242200.0 False True 19619762.156405404 11125595.902874269 17154370.568945903 1.0 0.5670606918770428 0.8743414131218402 24.225804216581416 -10.081624364809255 6.01435483630868 1.0000008368205873 0.7207010524994321 0.5241621697021773 0.12544682914072583 1.4076065757935082e-06 2.148707037434885e-07 0.12146373380727513 0.04048779000804153 8.286585871602236e-11 10.081624364809255 -0.2792997843211552 SIYGEKFEDENFILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIYGEKFEDENFILK 15 1 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 740192000.0 44211000.0 635910000.0 60071000.0 False True 67071319.25704361 522426892.112492 48197940.5199454 1.0 7.789125037340435 0.7186073131383025 25.999192643584568 -6.655410068092379 1.9891327249134518 5.38655997741102 0.7482904435444955 0.21622624228505893 2.893873278775144 0.495474798988456 3.7635780425580743 1.177382070969646 3.2067039859161337 2.2110060549003602e-07 6.655410068092379 -4.6382695338665245 SIYGEKFEDENFILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIYGEKFEDENFILK 15 1 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 122348600.0 14505000.0 75100700.0 32742900.0 False True 19867890.48288612 71782502.74919581 25009701.38119304 1.0 3.6129906600314765 1.2588000423465187 24.24393536360121 -6.621225831392686 2.1124976938126916 2.7323198373969357 1.2678918455316923 0.08684395959494118 1.1233303911573795 0.582124196448236 4.938232686469373 0.43670299388628714 1.2452265553668833 2.3920715653045506e-07 6.621225831392686 -1.4644279918652434 SIYGEKFEDENFILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIYGEKFEDENFILK 15 1 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 31631600.0 20263000.0 7311200.0 4057400.0 False True 16849582.30310364 7271813.114440425 4905783.580702025 1.0 0.4315723074690688 0.2911516435513298 24.006209492015692 -13.999999999999998 0.1963730802725062 4.117218209088131 0.19662646415148202 0.9994871471967263 0.006940309759901167 12.461516661013205 0.14052441533886545 14.898262645737889 0.09189236884027346 1.0000000000000041e-14 13.999999999999998 -3.920591744936649 SIYGEKFEDENFILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIYGEKFEDENFILK 15 1 P62937;F8WE65;C9J5S7;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 187846700.0 44211000.0 69328500.0 74307200.0 False True 57232011.02909819 65470308.03035056 60784052.05625779 1.0 1.1439456145803406 1.0620638863337102 25.770318965677017 -10.095165778478993 4.144654497036947 0.9999820604729951 1.1030047504819933 0.6784549703954941 0.03342807566470906 4681378.763902623 5707169.0421330435 600.2319340525099 0.011443319324816272 8.03219459487237e-11 10.095165778478993 0.10302269000899822 SIYYITGESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SIYYITGESK 10 0 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 1083940000.0 303460000.0 295120000.0 485360000.0 False True 397838998.7108199 251089246.36874998 435139603.10187364 1.0 0.6311328129780988 1.0937580390859738 28.567609464352934 -6.694314484798476 1.8511172069178707 0.7696869604031255 1.0922469735273515 0.3907062145897633 0.15587057173367364 0.4074443754835637 2.710147915840726 0.06727978597168467 0.17425236544812972 2.0215547840969135e-07 6.694314484798476 0.322560013124226 SIYYITGESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SIYYITGESK 10 0 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 608690000.0 145850000.0 111400000.0 351440000.0 False True 141220071.58425382 155882600.94332534 259387321.02599367 1.0 1.1038275168294591 1.836759591721632 27.073369912276895 -6.932500411957922 0.7259735163919692 0.9898230878246675 1.9972788568063615 0.9970072994071909 0.020372360438629045 0.09135997331238625 0.07147076150140587 0.0188443919730684 0.06542967650153537 1.168152621788404e-07 6.932500411957922 1.007455768981694 SIYYITGESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SIYYITGESK 10 0 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 882570000.0 219470000.0 503180000.0 159920000.0 False True 332952035.40619683 413383597.63671607 128311741.90457393 1.0 1.2415710182771338 0.385376054986525 28.310739118780777 -6.831345321058756 1.3218259790504634 1.1289644665022884 0.36168625107212177 0.9085527151151069 0.10899498264140996 0.17915439041168776 0.6117051891240527 0.06473258073932228 0.1489694431692088 1.4745336194560064e-07 6.831345321058756 -0.7672782154301667 down SIYYITGESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SIYYITGESK 10 0 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 814670000.0 303460000.0 169140000.0 342070000.0 False True 415657362.6981468 161666835.52881655 261280111.15279046 1.0 0.3889425522969025 0.6285949308265564 28.630819525875825 -10.26706058068918 5.61300246216904 1.0000377828948115 0.5087687415617362 0.8485319711019281 0.09783767384036754 4.626284407247543e-05 6.040906307444361e-06 0.09473818437658636 0.03157697345127922 5.4067889720060655e-11 10.26706058068918 -0.49126904133307525 SIYYITGESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SIYYITGESK 10 0 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 374836000.0 145850000.0 138140000.0 90846000.0 False True 121280737.250539 137395812.40135685 109841478.5755547 1.0 1.1328741522862587 0.9056795090934074 26.85377518771117 -6.748160668339425 1.6564629588600042 1.0783018316007715 0.9052850049580603 0.6411218892865778 0.05583034912888696 0.30325132027494384 1.6365095212397334 0.026630762500623503 0.064782432516418 1.7858267815045523e-07 6.748160668339425 -0.17301682664271123 SIYYITGESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SIYYITGESK 10 0 P08238;Q58FF8 P08238;Q58FF8 HSP90AB1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta 2 0 633170000.0 219470000.0 246730000.0 166970000.0 False True 284108241.40047014 232999258.60689923 136583173.2568764 1.0 0.8201073557682219 0.48074343983690715 28.081865440873226 -6.9611714056282255 0.41859769791177215 1.0152288705420982 0.27284965754646195 0.9998112063710344 0.0029581565126514824 0.07928530311393141 0.01960459354752178 0.00438620004585345 0.028260549874265888 1.0935246930918346e-07 6.9611714056282255 -0.7423792129956363 down SK(ub)ADYTSHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKADYTSHLR 10 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 5288900.0 1352800.0 1641600.0 2294500.0 True False 1773533.9005338368 1396679.6789066817 2057087.150398159 1.0 0.7875122536345535 1.1598803664136175 20.75819547651558 -6.751942676747907 1.6428376393157498 0.8753466788385558 1.16072336818327 0.6572227036455947 0.08929822166665703 0.2966647366021744 1.575931739282743 0.042930107324329295 0.10400354446560015 1.7703426133673106e-07 6.751942676747907 0.2853766893447143 SK(ub)ADYTSHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKADYTSHLR 10 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 4919460.0 765760.0 1026200.0 3127500.0 True False 741451.3679558311 1435967.011562303 2308313.927011136 1.0 1.9366975011742709 3.1132371275746897 19.499992543367764 -6.968038653206732 0.3013736921662877 0.7992512983266991 4.28762151555567 0.9999627888101648 0.005273992376198177 0.07694438999478265 0.01129591868772472 0.019387387650703268 0.10536603685415676 1.0763694100159501e-07 6.968038653206732 3.4883702172289706 SK(ub)ADYTSHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKADYTSHLR 10 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 4752480.0 1352800.0 990680.0 2409000.0 True False 1852966.7180453895 946908.4818593349 1840043.814912365 1.0 0.5110229302219662 0.9930258309514289 20.821405538038473 -10.937824114713496 10.662803822240548 1.0538815048346781 0.7520243805866983 0.2608496182828106 0.19677686022142624 0.11176199946200044 0.000651694753581481 0.08448250468776135 0.06350945854638071 1.1539204904295476e-11 10.937824114713496 -0.30185712424797984 SK(ub)ADYTSHLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKADYTSHLR 10 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 5806160.0 765760.0 2453700.0 2586700.0 True False 636763.3689199351 2440481.431078686 3127567.010450512 1.0 3.8326347748586422 4.911662892536402 19.28039781880204 -9.179243086087268 0.3386993833880676 7.969511475828196e-26 5.239130881590999 0.9982916703789978 0.0681792354687259 0.5939155096293186 0.12645307902526623 1.089047067266235 0.3243710357487085 6.618459473563149e-10 9.179243086087268 5.239130881590999 SK(ub)AEEVVSFVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKAEEVVSFVK 11 1 Q9BWH2 Q9BWH2 FUNDC2 FUN14 domain-containing protein 2 1 11747500.0 2636200.0 4000200.0 5111100.0 True False 3456083.7289971164 3403385.7526574694 4582252.401133157 1.0 0.9847521123699919 1.325851096339854 21.72070673877743 -6.896434211463146 0.9835118088010802 0.9843978249576641 1.3591745324998683 0.9847079508335091 0.019454950360600465 0.11407870927839496 0.19258091995242263 0.014929433331221676 0.03819443103473248 1.2693044088160321e-07 6.896434211463146 0.37477670754220416 SK(ub)AEEVVSFVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKAEEVVSFVK 11 1 Q9BWH2 Q9BWH2 FUNDC2 FUN14 domain-containing protein 2 1 12544700.0 2739100.0 3355800.0 6449800.0 True False 2652148.769807534 4695788.440265815 4760403.890147545 1.0 1.7705599677225452 1.7949234011080786 21.338730273675026 -11.17447556284044 0.5797294504914248 4.0243577571623626e-20 1.7922884180109397 0.9999169360823503 0.003364151112341939 3.353771164512712 0.28599135120934566 4.367343135868451 0.004355171125648649 6.691514712293423e-12 11.17447556284044 1.7922884180109397 SK(ub)AEEVVSFVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKAEEVVSFVK 11 1 Q9BWH2 Q9BWH2 FUNDC2 FUN14 domain-containing protein 2 1 57472300.0 8270300.0 21359000.0 27843000.0 True False 12546649.739918303 17547319.571371302 22339818.845979553 1.0 1.3985661459523266 1.7805405673279773 23.580798845210996 -6.971642783829826 0.21536353222251242 0.8132044735569895 2.376630598264741 0.9999925175438793 0.0008716961376604992 0.0757731503181816 0.007090759299888049 0.010966000707450484 0.03910505330573499 1.067473779438671e-07 6.971642783829826 1.5634261247077514 SK(ub)AEEVVSFVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKAEEVVSFVK 11 1 Q9BWH2 Q9BWH2 FUNDC2 FUN14 domain-containing protein 2 1 8119000.0 2636200.0 2700600.0 2782200.0 True False 3610874.3806262976 2581278.5623100502 2125101.661207631 1.0 0.7148624654902378 0.5885282724344006 21.78391680030032 -13.99999999973829 0.11034473230594084 2.374997730917921 0.357918877706564 0.9997413111766321 0.00276805355845644 12.010581975509393 0.10085668524138364 3.6768902890557214 0.20481086540843949 1.000000000602611e-14 13.99999999973829 -2.017078853211357 SK(ub)AEEVVSFVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKAEEVVSFVK 11 1 Q9BWH2 Q9BWH2 FUNDC2 FUN14 domain-containing protein 2 1 10782400.0 2739100.0 4348100.0 3695200.0 True False 2277683.0127044953 4324675.922269721 4467849.235325608 1.0 1.8987172043464682 1.96157639601506 21.119135549109302 -11.037346083548064 0.47007878328558017 6.945564743235414e-17 1.9607402007375887 0.9997269377227841 0.00725802525043534 2.8881268003545393 0.22877510298868622 3.120214556722503 0.01355901049953608 9.17601080848553e-12 11.037346083548064 1.9607402007375887 SK(ub)AEEVVSFVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKAEEVVSFVK 11 1 Q9BWH2 Q9BWH2 FUNDC2 FUN14 domain-containing protein 2 1 36247000.0 8270300.0 18667000.0 9309700.0 True False 10706066.381985275 17628165.04038822 7615430.125588677 1.0 1.6465585408708578 0.7113191581179522 23.351925167303445 -6.720697180870706 1.7565766755648942 1.393055848443827 0.7126951433567421 0.5159298189077246 0.27205053759282904 0.35395409979752407 2.134739750656182 0.12294939772448138 0.30842299344166313 1.9024043009582837e-07 6.720697180870706 -0.6803607050870848 SK(ub)AELMEISEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKAELMEISEDK 12 1 P05455;E7ERC4;E9PFL9;E9PGX9 P05455 SSB Lupus La protein 1 10405900.0 3098200.0 3074600.0 4233100.0 True False 4061770.2030114825 2615881.6646969332 3795099.418762446 1.0 0.6440250270085351 0.9343461665922604 21.953677189964214 -9.953743182147512 6.506196410255559 1.0000000328660814 0.7891855968003931 0.41281581360222075 0.11852310892059313 5.652211185180598e-08 9.199194203858423e-09 0.11475952384801157 0.03825316891584629 1.1123893386524259e-10 9.953743182147512 -0.21081443606568828 SK(ub)AELMEISEDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKAELMEISEDK 12 1 P05455;E7ERC4;E9PFL9;E9PGX9 P05455 SSB Lupus La protein 1 10763300.0 3176100.0 3091300.0 4495900.0 True False 3075276.4440092416 4325672.2109165415 3318288.9158910858 1.0 1.4065962165265238 1.0790213420829993 21.552284672938665 -10.091150415802735 5.774297619041824 0.9999986281823252 1.242808779304785 0.4228211758298651 0.13373188249056686 2.3617951045893727e-06 3.7174614291932473e-07 0.1294860696695504 0.04316177947856558 8.10680234029923e-11 10.091150415802735 0.24281015112245985 SK(ub)AELMEISEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKAELMEISEDK 12 1 P05455;E7ERC4;E9PFL9;E9PGX9 P05455 SSB Lupus La protein 1 12213200.0 3098200.0 4893300.0 4221700.0 True False 4243688.26570685 4677097.8260208 3224621.4086407353 1.0 1.1021303953488577 0.7598629321335473 22.016887251487105 -6.826740287060099 1.3424770177773238 1.0547059253011968 0.7512550991762096 0.8991845098812998 0.04555266606280215 0.18486795357173544 0.6527542832495431 0.026650908481309615 0.06134378654008092 1.4902519985963953e-07 6.826740287060099 -0.3034508261249872 SK(ub)AELMEISEDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKAELMEISEDK 12 1 P05455;E7ERC4;E9PFL9;E9PGX9 P05455 SSB Lupus La protein 1 10717400.0 3176100.0 4584900.0 2956400.0 True False 2641067.8750869823 4560200.2336686 3574569.571150848 1.0 1.7266501465883046 1.3534561549400246 21.33268994837294 -10.137004131331786 4.479219613132572 0.9999425358505658 1.5400531505851551 0.7362990096529876 0.15235580944566404 106441363.43125957 11.54451652037572 80798.64839705791 0.052155446009009614 7.294505711457612e-11 10.137004131331786 0.5401106147345893 SK(ub)AELMEISEDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKAELMEISEDK 12 1 P05455;E7ERC4;E9PFL9;E9PGX9 P05455 SSB Lupus La protein 1 16808800.0 5777700.0 4705900.0 6325200.0 True False 7479346.545493667 4444012.528181441 5174078.502032673 1.0 0.5941712288834877 0.6917821591179076 22.8344807997637 -9.82794164541151 6.254656783022819 1.000000016667629 0.6429766940005522 0.9469145120300011 0.039849495399326924 9.272467496092399e-09 1.7005792143695983e-09 0.0385841100211693 0.012861369336284489 1.4861353155325494e-10 9.82794164541151 -0.3570233226670768 SK(ub)AELMEISEDKTK ddPTM_RPMI8226_Bortezomib_1h_R1 2 SKAELMEISEDKTK 14 2 P05455;E7ERC4;E9PFL9;E9PGX9 P05455 SSB Lupus La protein 1 20673450.0 5689460.0 8905700.0 6078290.0 True False 7458937.1568090115 7577004.274146706 5449366.857874746 1.0 1.0158289465181933 0.7305822187951005 22.830538641112756 -6.893767174000623 0.9998072986164379 1.0139713373211845 0.7041558996547533 0.9832027824053633 0.016964562667644085 0.11614068932468383 0.20440794027229714 0.012860114357989387 0.03252806845789541 1.277123293255562e-07 6.893767174000623 -0.30981543766643116 SK(ub)AELMEISEDKTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKAELMEISEDKTK 14 2 P05455;E7ERC4;E9PFL9;E9PGX9 P05455 SSB Lupus La protein 1 16606350.0 6161650.0 4041400.0 6403300.0 True False 5966051.793466692 5655152.095622577 4726083.635117641 1.0 0.9478885352311934 0.7921626896188001 22.508345071612318 -6.951538801386639 0.5416925313943415 1.0022675092927096 0.7305714774773161 0.9993165358436558 0.0023082761281658895 0.08287378146391972 0.033450986611901205 0.002532981257885307 0.012899825154985778 1.1180499296341065e-07 6.951538801386639 -0.2716960318153935 SK(ub)AELMEISEDKTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKAELMEISEDKTK 14 2 P05455;E7ERC4;E9PFL9;E9PGX9 P05455 SSB Lupus La protein 1 9587100.0 3703000.0 1617400.0 4266700.0 True False 5617721.725562252 1328762.33319612 3423384.874838954 1.0 0.2365304652150833 0.6093902549963567 22.421553731507515 -10.679815810685414 6.686652214456692 1.004171049363277 0.4229603601136037 0.7615323694487733 0.1522193717609202 0.009494312132979962 0.0004546257896928075 0.14784043328061464 0.04912859098334994 2.0901824134444728e-11 10.679815810685414 -0.5812106892496732 SK(ub)AELMEISEDKTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKAELMEISEDKTK 14 2 P05455;E7ERC4;E9PFL9;E9PGX9 P05455 SSB Lupus La protein 1 15212300.0 4840900.0 4854200.0 5517200.0 True False 6630711.550403552 4639725.393307212 4214150.990300749 1.0 0.6997326543370497 0.6355503415081104 22.660732265477474 -13.999999999999998 0.21685109952138398 2.7873321258968393 0.6001657869926238 0.9994949393597311 0.0035699469282501344 12.915877757169222 0.14754703176996103 9.869315151887461 0.03627256170509623 1.0000000000000041e-14 13.999999999999998 -2.1871663389042153 SK(ub)AELQSEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKAELQSEER 10 1 C9JKQ0;A0A0C4DFR3;Q9NQR1-2;Q9NQR1 C9JKQ0 SETD8 N-lysine methyltransferase SETD8 1 18582640.0 771440.0 2379200.0 15432000.0 True False 1011365.3106355874 2024232.6340489644 13835244.674196733 1.0 2.001485133771145 13.679769840535705 19.947872769975096 -6.92381020100974 0.7959452957093489 0.775964859024837 15.73864736043196 0.9951757718722679 0.3997778378264164 0.09598148200418004 0.09437118213970463 0.3515928915812713 1.0948382492705604 1.1917627283040401e-07 6.92381020100974 14.962682501407123 up SK(ub)AELQSEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKAELQSEER 10 1 C9JKQ0;A0A0C4DFR3;Q9NQR1-2;Q9NQR1 C9JKQ0 SETD8 N-lysine methyltransferase SETD8 1 63669340.0 2571340.0 3895000.0 57203000.0 True False 2489714.219180356 5450293.812156665 42219818.24678434 1.0 2.1891242658167283 16.957696558717334 21.24754872196576 -6.922903391639471 0.8028957445966277 0.7069675160679746 19.50594905759446 0.9949502282789635 0.5158019123386368 0.09649347010077067 0.09698062066375476 0.45139097905690595 1.3920640837943794 1.1942537354328466e-07 6.922903391639471 18.798981541526487 up SK(ub)AELQSEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKAELQSEER 10 1 C9JKQ0;A0A0C4DFR3;Q9NQR1-2;Q9NQR1 C9JKQ0 SETD8 N-lysine methyltransferase SETD8 1 49138750.0 771440.0 1747310.0 46620000.0 True False 1056662.2153821224 1670108.0666185208 35609316.16903881 1.0 1.5805505698096312 33.69981026165619 20.011082831497987 -6.910817629091579 0.8901409106388242 0.03106617828607819 37.924216316358404 0.991226711537564 1.431198916202665 0.10387981891214214 0.13584983133450015 1.1765014277437533 3.2664027692019744 1.2279547712433376e-07 6.910817629091579 37.89315013807233 up SK(ub)AELQSEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKAELQSEER 10 1 C9JKQ0;A0A0C4DFR3;Q9NQR1-2;Q9NQR1 C9JKQ0 SETD8 N-lysine methyltransferase SETD8 1 47012840.0 2571340.0 3848500.0 40593000.0 True False 2138183.139676384 3827767.3666325645 49080808.61917417 1.0 1.790196216406374 22.95444562648763 21.027953997400036 -6.914796199558161 0.8624480353450257 0.4398718195492646 25.989745754147844 0.9926088671482343 0.8741853691341427 0.10133085467848638 0.12220027815642688 0.7331345400442718 2.0977571210243062 1.2167568515779528e-07 6.914796199558161 25.54987393459858 up SK(ub)ATEHATELAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKATEHATELAK 12 1 Q5R3K2;Q5R3K3-2;Q5R3K3 Q5R3K2 FAM26F Protein FAM26F 1 8129900.0 1168200.0 3202600.0 3759100.0 True False 1772244.8068597922 2631071.0079719895 3016112.237327941 1.0 1.4845979504569324 1.7018598252642843 20.75714647188997 -11.046793871913309 0.15205420982443044 4.17871087216485e-18 1.9854306043927707 0.9996341277806459 0.005611702314240603 3.300789642240991 0.08926051126973437 1.3495807721552708 0.20074592725489612 8.978548399481467e-12 11.046793871913309 1.9854306043927707 SK(ub)DASLVTNEDHQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKDASLVTNEDHQR 14 1 P49454 P49454 CENPF Centromere protein F 1 19239900.0 1852700.0 5215200.0 12172000.0 True False 2810681.350512872 4284506.813456419 9766198.864822876 1.0 1.5243659024793452 3.474673094138122 21.422488472671397 -6.946547431153959 0.5955434151584115 0.9777994179991425 4.120315264493841 0.9989017336946378 0.035284939384196044 0.0849024671156914 0.04193349414410462 0.03637539564953055 0.16366529186636783 1.1309738641057195e-07 6.946547431153959 3.1425158464946983 SK(ub)DASLVTNEDHQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKDASLVTNEDHQR 14 1 P49454 P49454 CENPF Centromere protein F 1 4260930.0 673430.0 1471200.0 2116300.0 True False 559986.8830074078 1463274.3535896628 2558808.5453343727 1.0 2.613051123146229 4.569408003973771 19.095033508675275 -6.968547788861375 0.2907865510081878 0.6213194331498928 6.621649586073035 0.9999687361935821 0.008160371607084188 0.07677677360152126 0.010708072646194647 0.03403478754399878 0.17725036961439417 1.0751082912036578e-07 6.968547788861375 6.0003301529231425 SK(ub)DASLVTNEDHQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKDASLVTNEDHQR 14 1 P49454 P49454 CENPF Centromere protein F 1 14654700.0 1852700.0 4702600.0 8099400.0 True False 2398356.6721768365 4440896.176082369 6625392.306861974 1.0 1.8516412623697245 2.7624716472419113 21.193614794763846 -6.970270837620153 0.25163269204938776 0.7166891832310371 3.924156317688699 0.9999844188759938 0.0028407082205999406 0.07621491343671152 0.008715115608618835 0.020092213248974488 0.08706348488182816 1.0708512855439814e-07 6.970270837620153 3.2074671344576617 SK(ub)DQDDQKPGPSER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKDQDDQKPGPSER 14 2 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 1 2968790.0 1169000.0 1367500.0 432290.0 True False 1532570.3206121046 1163474.3304732488 387560.77761848737 1.0 0.7591653804234968 0.25288286769359897 20.547521841524617 -7.005381197322295 0.4616164105402534 1.0146691598305435 1.579298744391625e-13 0.9997239356961556 0.005173305649966103 0.07472833951766407 0.02298198639682049 0.006771996944103345 0.038918374443449505 9.876857834757184e-08 7.005381197322295 -1.0146691598303856 down SK(ub)DQDDQKPGPSER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKDQDDQKPGPSER 14 2 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 1 2836390.0 1169000.0 1078900.0 588490.0 True False 1601210.8910371528 1031230.6305548078 449500.7823319957 1.0 0.6440317364359472 0.28072553393690725 20.61073190304751 -7.426433886896209 0.30744417513403477 1.0789273278705684 2.1517936192555127e-14 0.9997415833107416 0.004720483736869374 0.1183203686114388 0.028320209684034058 0.01863795780713623 0.059559209389686465 3.74598568228129e-08 7.426433886896209 -1.078927327870547 down SK(ub)DSLVDIIGICK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKDSLVDIIGICK 13 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 8739300.0 1490600.0 2182000.0 5066700.0 True False 1929611.0841187432 2060569.7818678478 4144612.5887322007 1.0 1.0678679236592972 2.147900487742613 20.87987866886242 -6.919720002973377 0.8268049999465054 0.9759286515059592 2.3209463768065266 0.9941027305268357 0.040382670170966944 0.09833667723718281 0.10647129984700285 0.03474234238175337 0.10379224285161616 1.2030398048326758e-07 6.919720002973377 1.3450177253005675 up SK(ub)ENCVVDNIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKENCVVDNIK 11 1 Q9H9Y6;Q9H9Y6-3;Q9H9Y6-2;Q9H9Y6-4;Q9H9Y6-5;H7C0D9 Q9H9Y6 POLR1B DNA-directed RNA polymerase I subunit RPA2;DNA-directed RNA polymerase 1 13129000.0 4178200.0 4381600.0 4569200.0 True False 6338634.867335727 3599669.246402948 3666095.6172484937 1.0 0.5678934536760865 0.578373055709618 22.59574073426471 -10.03779524397113 5.202352666351296 1.0000042127318531 0.5731332546916019 0.9995481745176186 0.004278279619294938 5919421.667471802 0.0785817982928546 298.71788663210606 0.001464568908585278 9.166525607745293e-11 10.03779524397113 -0.4268709580402512 SK(ub)ENCVVDNIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKENCVVDNIK 11 1 Q9H9Y6;Q9H9Y6-3;Q9H9Y6-2;Q9H9Y6-4;Q9H9Y6-5;H7C0D9 Q9H9Y6 POLR1B DNA-directed RNA polymerase I subunit RPA2;DNA-directed RNA polymerase 1 9703800.0 4178200.0 3018400.0 2507200.0 True False 5408762.264635006 2850423.3866131534 2050915.3260444421 1.0 0.5270010488814681 0.37918385495592527 22.366867056357158 -13.999999999999998 0.1628383183131431 3.343971012134813 0.23832881754003785 0.9995291920446052 0.005745288912389647 12.029803792344994 0.1276123165157798 8.904618014774133 0.12884966535568446 1.0000000000000041e-14 13.999999999999998 -3.105642194594775 SK(ub)EYFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKEYFSK 7 1 Q06830;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 1 5128100.0 1634700.0 2382000.0 1111400.0 True False 1582807.3432895397 3333145.021965899 820290.9987146865 1.0 2.105843794633049 0.5182506905798657 20.59405423301431 -6.719375299416655 1.7614056667137106 1.6732086084864157 0.5207802257647456 0.5096929476086546 0.4653766450210376 0.35650522357155734 2.1612638975002407 0.20980572582234802 0.5271095495887433 1.908203554891215e-07 6.719375299416655 -1.1524283827216701 SK(ub)EYFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKEYFSK 7 1 Q06830;A0A0A0MRQ5 Q06830 PRDX1 Peroxiredoxin-1 1 4318360.0 1634700.0 1853900.0 829760.0 True False 1359325.479488898 1843912.6727296612 1003258.9796232331 1.0 1.356490921823202 0.7380564807778451 20.374459508448588 -6.750384803761178 1.648294260332539 1.2095224185467164 0.7367819583182446 0.6506702253702681 0.1498031935839441 0.29937795929442457 1.6004057162345204 0.07178886647912099 0.17422223886715496 1.7767044751301843e-07 6.750384803761178 -0.4727404602284718 SK(ub)FDNLYGCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKFDNLYGCR 10 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 51801400.0 16046900.0 17627600.0 18126900.0 True False 21037641.298400648 14997630.791846644 16251302.273502896 1.0 0.712895071225823 0.7724868982692643 24.32646962559765 -10.76982085278248 6.9987381746862924 1.006302188832939 0.7426909847476119 0.961328030571225 0.024328261516103133 0.0024259693678651234 7.978678784745279e-05 0.023886797100649483 0.007851912641170522 1.698944325381102e-11 10.76982085278248 -0.26361120408532723 SK(ub)FDNLYGCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKFDNLYGCR 10 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 27492000.0 11285200.0 7881200.0 8325600.0 True False 10926957.503206179 11028204.259915056 6144875.597353776 1.0 1.009265777475493 0.5623592473523167 23.381388417822436 -6.902166070596805 0.9474654827831122 1.0174926303311151 0.5133282500092035 0.9876136750471805 0.023207453660812036 0.10982864028757532 0.16856104255903598 0.018293128315477695 0.048134674928537784 1.252662075789119e-07 6.902166070596805 -0.5041643803219117 SK(ub)FDNLYGCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKFDNLYGCR 10 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 98809400.0 29056000.0 22821400.0 46932000.0 True False 44080076.278135754 18748742.865587957 37655869.62897367 1.0 0.42533372100555006 0.8542605369231503 25.3936233846268 -9.805833185512327 6.224006336343596 1.0000000133059328 0.6397971289641293 0.4846159208293699 0.1751086393333155 3.246380386706626e-08 6.088840460066014e-09 0.16954821855775898 0.056516070326123186 1.5637481700921764e-10 9.805833185512327 -0.3602028843418035 SK(ub)FDNLYGCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKFDNLYGCR 10 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 41944200.0 16046900.0 13779100.0 12118200.0 True False 21979872.581166863 13170293.800609637 9256130.742163135 1.0 0.599197913999484 0.4211184895627701 24.38967968712054 -13.999999999999996 0.10989327799486015 2.9342722596709616 0.09393601626383975 0.9997436044369615 0.0038763914014060237 12.013251893578126 0.10057677104685116 5.15674499342227 0.2906131767133135 1.0000000000000082e-14 13.999999999999996 -2.8403362434071218 SK(ub)FDNLYGCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKFDNLYGCR 10 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 38629400.0 11285200.0 7538600.0 19805600.0 True False 9384143.819127752 7497988.065505055 23946859.389252197 1.0 0.7990060904887097 2.551842752073043 23.161793693256712 -6.878371932964734 1.0889003492232738 0.8779333347159237 2.6722213368995753 0.9723455709794279 0.13024827075420825 0.12907911657306056 0.28111805028089343 0.09227648299358002 0.22224282840365445 1.3232078449555675e-07 6.878371932964734 1.7942880021836516 up SK(ub)FDNLYGCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKFDNLYGCR 10 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 78187300.0 29056000.0 18670300.0 30461000.0 True False 37613564.779386975 17631281.39248728 24917410.556253903 1.0 0.4687479502647299 0.6624580972955046 25.16474970671925 -10.0759990741431 5.087401548045535 1.0000086521303335 0.5656030237787183 0.8702164345118079 0.07908183637568568 7.760774656202539e-06 1.409642698641094e-06 0.07657218238680295 0.025523552938512467 8.394617761360783e-11 10.0759990741431 -0.4344056283516152 SK(ub)GFGFVCFSSPEEATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKGFGFVCFSSPEEATK 17 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YB86;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 4 1 16305500.0 0.0 10409000.0 5896500.0 True False 0.0 8856017.773964202 5286386.743221942 0.0 SK(ub)GFGFVCFSSPEEATK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKGFGFVCFSSPEEATK 17 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YB86;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 4 1 62360000.0 11629000.0 10928000.0 39803000.0 True False 17642043.193778925 8977813.019146299 31935919.603725355 1.0 0.5088873732217211 1.8102166088668714 24.072514318918376 -6.804485948599478 1.4377234197945437 0.7305481320393215 1.8301890686585143 0.844882669474778 0.21132507039246007 0.21443142607165797 0.8745669111160503 0.11561306010384806 0.2681491044611364 1.568606648414266e-07 6.804485948599478 1.0996409366191928 SK(ub)GFGFVCFSSPEEATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKGFGFVCFSSPEEATK 17 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YB86;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 4 1 15969200.0 0.0 8364100.0 7605100.0 True False 0.0 7994546.405620048 5808932.011951019 0.0 SK(ub)GFGFVCFSSPEEATK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKGFGFVCFSSPEEATK 17 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YB86;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 4 1 18381300.0 8093700.0 6032500.0 4255100.0 True False 6730270.161705085 6000001.725142497 5144821.736640504 1.0 0.8914949297700142 0.7644301956724253 22.682232986957583 -6.96904503234109 0.2800658761355689 1.027970777344525 0.6240821145571092 0.9999739387056227 0.0004914290793670125 0.07661388789189606 0.010134985325113845 0.002346146373573506 0.01166197081934132 1.0738780552962408e-07 6.96904503234109 -0.40388866278741586 SK(ub)GFGFVCFSSPEEATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKGFGFVCFSSPEEATK 17 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YB86;B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 P11940;B1ANR0 PABPC1;PABPC3;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3;Polyadenylate-binding protein 4 1 42990000.0 11629000.0 13457000.0 17904000.0 True False 15053969.741860231 12708106.120346284 14645655.710553471 1.0 0.8441697663978387 0.9728766539119996 23.843640641010825 -10.087467045053039 4.7760286487415105 1.0000040089170428 0.9085232101672859 0.4024606902267138 0.05254436680258453 2.2430806376325017e-06 4.285350960145513e-07 0.050878094359850266 0.01695862146305014 8.175850752286776e-11 10.087467045053039 -0.0914807987497569 SK(ub)GFGFVSFER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKGFGFVSFER 11 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;Q9H361;H0YAP2 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 1 43953400.0 8415100.0 8708300.0 26830000.0 True False 12766321.92621626 7154235.826741553 21527038.739993274 1.0 0.5603991398689377 1.6862365577501581 23.605839597777422 -6.800802006722815 1.4525784921479779 0.7576967386283413 1.7020968269980843 0.8345073661903668 0.188467124982915 0.21961857692788203 0.9147558749555386 0.10206568342780575 0.23725822693175774 1.581969088858733e-07 6.800802006722815 0.944400088369743 SK(ub)GFGFVSYEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKGFGFVSYEK 11 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 2829800.0 1442600.0 1387200.0 0.0 True False 1891262.5701582727 1180235.1672632485 0.0 1.0 0.6240461720576848 0.0 20.850918240580324 -7.59370306316792 0.6802794768792936 0.9962213252143981 5.877635240072107e-21 0.987114667492597 0.04681469778293263 0.1211334210451681 0.1462991310783874 0.042281887809645785 0.07704237980827545 2.5485721727088772e-08 7.59370306316792 -0.9962213252143981 down SK(ub)GFGFVSYEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKGFGFVSYEK 11 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 4501200.0 1117000.0 2358500.0 1025700.0 True False 1081541.4464148872 3300261.3494150164 757038.3996595757 1.0 3.051442328312781 0.6999624491220563 20.044657522087306 -6.676140277828057 1.915123381622707 2.3024804027376993 0.7090901478120674 0.3065374221813134 0.8702029100818849 0.4472899807725042 3.1681979836362437 0.36501241041981863 0.9676512930085457 2.1079471695764542e-07 6.676140277828057 -1.593390254925632 SK(ub)GFGFVSYEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKGFGFVSYEK 11 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 16848700.0 2109400.0 5505500.0 9233800.0 True False 3200114.017796654 4523000.510332166 7408735.3826816855 1.0 1.4133872996957615 2.3151473170892696 21.60969187755537 -6.958312479372128 0.4586048376636126 0.9733458829727438 2.791455042912016 0.9997023782048272 0.009473048476444151 0.08030964348104162 0.02340165874643829 0.012218145043925759 0.07450600187059937 1.1007470256761323e-07 6.958312479372128 1.8181091599392722 up SK(ub)GFGFVSYEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKGFGFVSYEK 11 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 7014500.0 1442600.0 1380100.0 4191800.0 True False 1975968.2047991408 1319122.618619604 3201783.1728309016 1.0 0.6675829172836788 1.62036168651629 20.914128302103215 -6.812448934332624 1.4041092341894363 0.8193475630184239 1.6379970494276996 0.86614105822009 0.1444616250750086 0.20348559918898765 0.790190200773975 0.08088586708917239 0.186915967014365 1.540107605954429e-07 6.812448934332624 0.8186494864092757 SK(ub)GFGFVSYEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKGFGFVSYEK 11 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 5497240.0 1117000.0 1941900.0 2438340.0 True False 928834.9914902425 1931438.5992630317 2948185.62038965 1.0 2.0794205827282526 3.174068211684746 19.825062797521582 -6.970950809219928 0.23436616944560246 0.5784295864289113 4.706502134244889 0.999988878562679 0.0029599251213595296 0.07599536212094077 0.007917653966309664 0.027243423623299123 0.10781960551572442 1.0691759736043454e-07 6.970950809219928 4.128072547815978 SK(ub)GFGFVSYEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKGFGFVSYEK 11 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YCC8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 25135600.0 2109400.0 7827800.0 15198400.0 True False 2730659.8824903253 7392176.04881079 12432447.148753133 1.0 2.707102446632506 4.552909437192488 21.38081819964782 -6.970127825164832 0.2551197816241942 0.44991407892079555 6.864514191860054 0.9999833610744194 0.005918085501053494 0.07626128661514761 0.008881864912643115 0.03978084424975293 0.1754610942982203 1.0712039731695191e-07 6.970127825164832 6.414600112939258 SK(ub)IEDYFPEFAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKIEDYFPEFAR 12 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A0A0MR13;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 108805780.0 7055800.0 15727200.0 86022780.0 True False 9250222.128464404 13380763.064145442 77121967.91437246 1.0 1.4465342429962527 8.337309833572093 23.141056579254347 -6.920082432485079 0.8241143792026868 0.8484101529926794 9.450621838023196 0.9942037808168098 0.25569563031692794 0.09812340829220913 0.10536295619860198 0.22040379366239335 0.6607361258382988 1.202036257092073e-07 6.920082432485079 8.602211685030516 up SK(ub)IEDYFPEFAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKIEDYFPEFAR 12 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A0A0MR13;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 168788700.0 15365400.0 21207300.0 132216000.0 True False 14877633.787594723 29675485.48460848 97584663.20502159 1.0 1.9946374476129738 6.55915212043932 23.826641755552906 -6.941734635388334 0.6432229755369716 0.9499041704837686 7.855524156310145 0.9983823991376656 0.09735005276642276 0.08698410697091752 0.05107217235860807 0.09605829534414617 0.3899545410547893 1.1435768749569058e-07 6.941734635388334 6.905619985826377 SK(ub)IEDYFPEFAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKIEDYFPEFAR 12 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A0A0MR13;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 318112400.0 31190000.0 207074400.0 79848000.0 True False 47317510.29443324 170120355.44032806 64066007.80137839 1.0 3.5952938855352707 1.353959821696611 25.495870829597397 -6.610613677819813 2.151707456491824 2.7332627992142715 1.362068172913491 0.05215948121616687 1.1187558220809226 0.6110171939006808 5.361745054363018 0.4292551542389936 1.2417260834327415 2.4512427500453164e-07 6.610613677819813 -1.3711946263007806 SK(ub)IEDYFPEFAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKIEDYFPEFAR 12 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A0A0MR13;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 139531400.0 7055800.0 15543600.0 116932000.0 True False 9664519.935825445 14856832.356188452 89315069.89013392 1.0 1.5372550788700434 9.24154230972731 23.204266640777238 -6.920984027646253 0.8173954365153222 0.8359635695502221 10.512489946713375 0.9944499035638926 0.28047837334837034 0.09759633105438958 0.10263948104638095 0.24292820120831746 0.734673805279734 1.1995434187904948e-07 6.920984027646253 9.676526377163153 up SK(ub)IEDYFPEFAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKIEDYFPEFAR 12 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A0A0MR13;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 124656000.0 15365400.0 25740600.0 83550000.0 True False 12777010.902635783 25601930.278690927 101019918.70844729 1.0 2.003749583825547 7.906381193398511 23.607047030987182 -6.936261749162372 0.693467318239535 0.9275539556133268 9.337109049653204 0.9976321349071395 0.1482592524676896 0.08951419726958211 0.06269031944350507 0.14051775357970048 0.516945550489139 1.1580791717866413e-07 6.936261749162372 8.409555094039877 SK(ub)IEDYFPEFAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKIEDYFPEFAR 12 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A0A0MR13;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 249690000.0 31190000.0 158167000.0 60333000.0 True False 40376069.84681574 149364867.41003296 49353013.06885735 1.0 3.699341416257546 1.2223332596783085 25.266997151689846 -6.625804011554567 2.096146120136999 2.7838496341577605 1.2322279697867058 0.1023862081693031 1.1591258841319345 0.5700619270201712 4.767688312643875 0.45319551210569503 1.2840918673525394 2.366987630849605e-07 6.625804011554567 -1.5516216643710548 SK(ub)IITYIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKIITYIR 8 1 Q15046;Q15046-2;J3KRL2;H3BPV7 Q15046 KARS Lysine--tRNA ligase 1 8395900.0 3058300.0 3925400.0 1412200.0 True False 4009460.916619331 3339745.621089359 1266079.090778941 1.0 0.8329662492147054 0.31577289743142445 21.93497684460742 -6.9507378035414025 0.5506828210722317 1.0071238449207547 0.11728978326636123 0.9992579270589907 0.007934551172181515 0.08319079730427684 0.03474648444013348 0.008604436972647102 0.04291113264017624 1.1201139253693114e-07 6.9507378035414025 -0.8898340616543935 down SK(ub)IITYIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKIITYIR 8 1 Q15046;Q15046-2;J3KRL2;H3BPV7 Q15046 KARS Lysine--tRNA ligase 1 11982700.0 4892000.0 3142900.0 3947800.0 True False 4736706.137745411 4397876.3600069815 2913752.7485386305 1.0 0.9284672158489219 0.6151432374746232 22.175452740131377 -6.94279540365875 0.6330291359542934 1.003419134879927 0.5232171329893712 0.9985075297598044 0.006456797153219597 0.08651434641681312 0.04897486145849265 0.00642728691810451 0.026652892136084332 1.1407870863405355e-07 6.94279540365875 -0.48020200189055584 SK(ub)IITYIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKIITYIR 8 1 Q15046;Q15046-2;J3KRL2;H3BPV7 Q15046 KARS Lysine--tRNA ligase 1 33585200.0 15355000.0 9414700.0 8815500.0 True False 23294657.600866392 7734573.227613157 7073112.561029084 1.0 0.33203206332277174 0.3036366828060188 24.47349578919912 SK(ub)IITYIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKIITYIR 8 1 Q15046;Q15046-2;J3KRL2;H3BPV7 Q15046 KARS Lysine--tRNA ligase 1 7208900.0 3058300.0 1899500.0 2251100.0 True False 4189036.157449892 1815573.8091934887 1719436.5428597855 1.0 0.43341087089081926 0.4104611366989264 21.99818690613031 SK(ub)IITYIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKIITYIR 8 1 Q15046;Q15046-2;J3KRL2;H3BPV7 Q15046 KARS Lysine--tRNA ligase 1 10832700.0 4892000.0 3322800.0 2617900.0 True False 4067914.752345804 3304899.41687584 3165290.786198012 1.0 0.8124308443214147 0.7781113860295905 21.955858015565653 -13.999999999999998 0.23886580262953672 2.2347405487025087 0.7627728893733969 0.9995230967006785 0.0021296852444969284 13.58371406743162 0.15469337080060697 7.995125197998902 0.016882333123781318 1.0000000000000041e-14 13.999999999999998 -1.4719676593291118 SK(ub)IITYIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKIITYIR 8 1 Q15046;Q15046-2;J3KRL2;H3BPV7 Q15046 KARS Lysine--tRNA ligase 1 33469200.0 15355000.0 11372000.0 6742200.0 True False 19877350.19230061 10739138.203208601 5515188.780813993 1.0 0.5402701114240243 0.2774609657453373 24.24462211129157 -8.910967244499671 0.2006637258852774 1.3802338648191523 1.033704381396218e-09 0.9996020046346885 0.005957107468523124 0.40027574930442344 0.0632661252809739 0.23578271053568017 0.13647122919447904 1.2275318109724387e-09 8.910967244499671 -1.3802338637854479 down SK(ub)INLQDLQGACTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKINLQDLQGACTK 14 1 P04035-2;P04035;P04035-3;H0Y8F6;H0Y8K6 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 13719800.0 3237400.0 6109300.0 4373100.0 True False 3134630.5090631684 8548775.349578615 3227653.9198121224 1.0 2.7272035172443805 1.0296760369300288 21.579863966368055 -6.642165112047914 2.036878259804054 2.1276347849470727 1.0367882477569794 0.1629246943397239 0.7386205487762719 0.5278876734872198 4.188549961642691 0.29504865520526674 0.8177979192385763 2.279475285978036e-07 6.642165112047914 -1.0908465371900933 SK(ub)INLQDLQGACTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKINLQDLQGACTK 14 1 P04035-2;P04035;P04035-3;H0Y8F6;H0Y8K6 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 11751300.0 3237400.0 3928800.0 4585100.0 True False 2692041.541137434 3907634.7745942576 5543823.210892896 1.0 1.451550696704039 2.0593379136900447 21.36026924180233 -6.966994814279559 0.3219827534608652 0.9186767653888269 2.6118730949002376 0.9999485574916478 0.003113063524187805 0.07729039978287032 0.012506756336838152 0.009140010830232404 0.05336950313200072 1.078959605537607e-07 6.966994814279559 1.6931963295114105 SK(ub)LSELAASTSVQEQNTTDEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKLSELAASTSVQEQNTTDEEK 22 1 Q2KHT3-2;Q2KHT3 Q2KHT3-2 CLEC16A Protein CLEC16A 1 69608000.0 25057000.0 24839000.0 19712000.0 True False 32849969.65233318 21133118.021663666 17672391.33085572 1.0 0.6433222996954178 0.5379728358318447 24.969388701960096 -13.999999997120431 0.17094623213780757 2.803234739856164 0.4459725172715203 0.9995119041604271 0.0043678786110890955 12.100855402167692 0.13094662997759063 7.236502370605861 0.08515568862447702 1.0000000066304518e-14 13.999999997120431 -2.3572622225846436 SK(ub)LSELAASTSVQEQNTTDEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKLSELAASTSVQEQNTTDEEK 22 1 Q2KHT3-2;Q2KHT3 Q2KHT3-2 CLEC16A Protein CLEC16A 1 141937000.0 56555000.0 32411000.0 52971000.0 True False 54759692.48164185 45352881.321132146 39096306.00406297 1.0 0.8282165086361043 0.7139613871493158 25.70661100897287 -8.373493302421158 0.05897621943817973 1.6999608931899997 5.58516343159046e-09 0.9999978035755577 0.00017413131100426905 0.10296544214781114 0.013009192924635623 0.18668937258699267 0.18176716883882665 4.231620355633872e-09 8.373493302421158 -1.6999608876048362 SK(ub)LSELAASTSVQEQNTTDEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKLSELAASTSVQEQNTTDEEK 22 1 Q2KHT3-2;Q2KHT3 Q2KHT3-2 CLEC16A Protein CLEC16A 1 114403000.0 56555000.0 33455000.0 24393000.0 True False 47027988.31130767 33274771.27470242 29493463.519511104 1.0 0.7075525122281628 0.6271470368724986 25.487016284407147 -13.999999999999998 0.18117673433911902 2.5228972541210175 0.5640467609885089 0.9994967653688108 0.003594005577795217 12.220144517194685 0.13494315289543463 6.553025939322591 0.05943838090091923 1.0000000000000041e-14 13.999999999999998 -1.9588504931325086 SK(ub)LTFSCLGGSDNFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKLTFSCLGGSDNFK 15 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 52988000.0 16364000.0 19056000.0 17568000.0 True False 21453362.469201405 16212919.07970621 15750231.88415552 1.0 0.7557285764868602 0.7341614586881968 24.354700448881005 -13.999999999999998 0.3435990600836182 3.888095324145524 0.7309243296787786 0.9997423243617487 0.0019351902708790308 20.03937793565882 0.18826329288282306 42.11175484587124 0.0065792085685392266 1.0000000000000041e-14 13.999999999999998 -3.157170994466745 SK(ub)LTFSCLGGSDNFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKLTFSCLGGSDNFK 15 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 222903000.0 29924000.0 34909000.0 158070000.0 True False 45396895.73743572 28679216.204738107 126827395.21545795 1.0 0.6317439934794553 2.7937459853862223 25.436090312887973 -6.8630382176897715 1.1702067146036077 0.7983300452335721 2.904723291396858 0.95723231325579 0.19530969433699363 0.1437094078112747 0.3722220099999596 0.12999964279102325 0.3045898390111771 1.370761134586347e-07 6.8630382176897715 2.106393246163286 up SK(ub)LTFSCLGGSDNFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKLTFSCLGGSDNFK 15 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 57959000.0 16364000.0 21330000.0 20265000.0 True False 22414213.02047214 20387570.071122482 15478824.37077586 1.0 0.9095822392917114 0.6905807648315913 24.417910510403896 -6.956136431014384 0.48684058309568 1.0049327898012599 0.5859931702702829 0.9995989826928292 0.0026013910405024037 0.08111125832398709 0.02645893508684112 0.0031319649101378723 0.018062908382742392 1.1062761993322806e-07 6.956136431014384 -0.418939619530977 SK(ub)LTFSCLGGSDNFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKLTFSCLGGSDNFK 15 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 1 181931000.0 29924000.0 32517000.0 119490000.0 True False 38737207.89022488 30707400.365259755 97744046.07093586 1.0 0.792710730527602 2.5232599713414303 25.207216634980423 -6.876982446573897 1.0964419280405207 0.875990426760067 2.6390441742855923 0.9711710079739992 0.13100820447213174 0.13033892578498693 0.28869691520775004 0.0922749902975024 0.22153961616354467 1.3274481097846926e-07 6.876982446573897 1.7630537475255252 up SK(ub)LYSIVCGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKLYSIVCGK 10 1 F5H061;P19438-3;P19438-2;P19438 F5H061 TNFRSF1A Tumor necrosis factor receptor superfamily member 1A;Tumor necrosis factor receptor superfamily member 1A, membrane form;Tumor necrosis factor-binding protein 1 1 7101100.0 1874000.0 2296500.0 2930600.0 True False 2456832.1478418144 1953871.1516868856 2627369.624300216 1.0 0.7952806842759889 1.069413564377285 21.228367864652146 -6.706792906261272 1.8065388524824855 0.873732192224696 1.0687128359368656 0.4498688830732447 0.08631233491049631 0.381576786988886 2.425439381295137 0.03804936099914756 0.09704461146707316 1.9642967303169586e-07 6.706792906261272 0.1949806437121696 SK(ub)LYSIVCGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKLYSIVCGK 10 1 F5H061;P19438-3;P19438-2;P19438 F5H061 TNFRSF1A Tumor necrosis factor receptor superfamily member 1A;Tumor necrosis factor receptor superfamily member 1A, membrane form;Tumor necrosis factor-binding protein 1 1 13702300.0 2351100.0 5081000.0 6270200.0 True False 3566790.5884335367 4174255.8519658 5030892.2216737075 1.0 1.1703114462346527 1.410481523077915 21.766195084849354 -6.96626305360598 0.33566956136885046 0.9726080624422697 1.6161143650774898 0.9999368622634216 0.0013379653018581778 0.07753492567235712 0.013362841302282187 0.003437155937695052 0.020855180271639615 1.0807791215084639e-07 6.96626305360598 0.6435063026352201 SK(ub)LYSIVCGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKLYSIVCGK 10 1 F5H061;P19438-3;P19438-2;P19438 F5H061 TNFRSF1A Tumor necrosis factor receptor superfamily member 1A;Tumor necrosis factor receptor superfamily member 1A, membrane form;Tumor necrosis factor-binding protein 1 1 6888300.0 1874000.0 1970700.0 3043600.0 True False 2566868.442945784 1883627.957766577 2324764.36490962 1.0 0.7338233336200479 0.9056811506247975 21.291577926175037 -10.727151091635228 5.729922172234515 1.0049256875668948 0.8197522421224255 0.5945992971258376 0.07016065999504041 0.004516504352506254 0.00021506788871433137 0.06949774736719087 0.02264425564330938 1.8743423084096806e-11 10.727151091635228 -0.18517344544446934 SK(ub)LYSIVCGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKLYSIVCGK 10 1 F5H061;P19438-3;P19438-2;P19438 F5H061 TNFRSF1A Tumor necrosis factor receptor superfamily member 1A;Tumor necrosis factor receptor superfamily member 1A, membrane form;Tumor necrosis factor-binding protein 1 1 4905750.0 1480200.0 835350.0 2590200.0 True False 1230851.8839783862 830849.8037460074 3131798.844268345 1.0 0.6750201340721165 2.5444156888688156 20.231225733172185 -6.862066199432677 1.17533724748189 0.8226353965295078 2.6385421111500076 0.9560980048576757 0.1708716670066353 0.14468345366921834 0.3786337712078547 0.1132965197275152 0.2650981526368152 1.373832545994204e-07 6.862066199432677 1.8159067146204997 up SK(ub)LYSIVCGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKLYSIVCGK 10 1 F5H061;P19438-3;P19438-2;P19438 F5H061 TNFRSF1A Tumor necrosis factor receptor superfamily member 1A;Tumor necrosis factor receptor superfamily member 1A, membrane form;Tumor necrosis factor-binding protein 1 1 12871300.0 2351100.0 3343100.0 7177100.0 True False 3043545.2971096025 3157053.5461789155 5870941.443264828 1.0 1.0372947460900646 1.9289811289617902 21.537321406941803 -6.915690517815908 0.8560807314281452 0.9771076639687726 2.059426162366216 0.9928976519754882 0.03618832912924823 0.10077417939935641 0.11924500645843093 0.03048821984406724 0.08788069428527069 1.2142538305172436e-07 6.915690517815908 1.0823184983974432 SK(ub)MSQVAPSLSALIGEAVGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKMSQVAPSLSALIGEAVGAR 21 1 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 1 5961700.0 1763500.0 2188700.0 2009500.0 True False 1466428.3862963684 2176909.0386770656 2429677.159121781 1.0 1.4844973399451826 1.656867244133351 20.48387518746452 -11.504725020522486 0.18475317774772365 2.3191923899303894e-19 1.808179411549079 0.9994465881505816 0.006541594137958736 4.13670828056488 0.11195696153149146 1.7805836963294397 0.12162257815963426 3.1280593136820604e-12 11.504725020522486 1.808179411549079 SK(ub)NILFVITKPDVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKNILFVITKPDVYK 15 2 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 1 186704300.0 70422000.0 92745000.0 23537300.0 True False 92323923.96761815 78907807.51717842 21101885.981724374 1.0 0.8546842912012131 0.22856357350155182 26.46020120717584 -6.943171423742212 0.6293782628177923 1.0068299734837676 0.042709948779845054 0.9985503708723152 0.012743625071955778 0.08634940341645524 0.04824344568645449 0.01272616854533295 0.05318218767818531 1.1397997995416762e-07 6.943171423742212 -0.9641200247039226 down SK(ub)NILFVITKPDVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKNILFVITKPDVYK 15 2 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 1 254422600.0 104372000.0 123342000.0 26708600.0 True False 101058767.99034436 172593103.82003286 19712816.419174973 1.0 1.7078488809256336 0.19506290063874943 26.590619256347743 -6.779443447269191 1.5378289507496288 1.401083949192254 0.18324121040126312 0.7655012772587148 0.29927472185360204 0.2514311366070027 1.1744085659382535 0.15327769927816254 0.36187135889731376 1.66171504801636e-07 6.779443447269191 -1.217842738790991 SK(ub)NILFVITKPDVYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKNILFVITKPDVYK 15 2 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 1 225721900.0 142178000.0 60706000.0 22837900.0 True False 215694420.6041019 49872540.001857094 18323979.054792818 1.0 0.2312184981984122 0.08495342162060704 27.68441361769787 -13.999999999999963 0.2333314697246085 5.929114569429994 0.016055412176019728 0.9995145203317026 0.008843161285912981 13.39734064894937 0.15292329320774062 30.651763579095235 0.07438224576229345 1.0000000000000858e-14 13.999999999999963 -5.913059157253974 SK(ub)NILFVITKPDVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKNILFVITKPDVYK 15 2 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 1 159710500.0 70422000.0 70709000.0 18579500.0 True False 96458916.48299262 67584842.57660572 14191404.756813733 1.0 0.7006593588320278 0.1471238250879163 26.52341126869873 -7.298332777008917 0.52773537630598 1.0079233955549105 2.6253290925755273e-27 0.9981594819374852 0.015157122926004055 0.0995940769232201 0.052856632384323254 0.01590421129812636 0.05711355124460313 5.031149505392616e-08 7.298332777008917 -1.0079233955549105 down SK(ub)NILFVITKPDVYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKNILFVITKPDVYK 15 2 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 1 278514400.0 104372000.0 162696000.0 11446400.0 True False 86789942.46358068 161819524.35537258 13839789.317826103 1.0 1.8644962741307987 0.1594630544159381 26.37102453178202 -6.76891264749007 1.5790869082244723 1.4965513036131552 0.15036853292365412 0.7262124879434046 0.36423219380385974 0.2681917430710688 1.3196946919822539 0.18184757442427807 0.4332229896895721 1.7025009091817126e-07 6.76891264749007 -1.346182770689501 SK(ub)NILFVITKPDVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKNILFVITKPDVYK 15 2 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5;F8VZ58;Q9BZK3 F8W0W4 NACA;NACAP1 Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form;Putative nascent polypeptide-associated complex subunit alpha-like protein 1 250951300.0 142178000.0 101591000.0 7182300.0 True False 184052223.74737337 95937371.54433388 5875195.096621322 1.0 0.5212508145297702 0.03192134806632657 27.45553993979032 -7.876856938885771 0.5483847895927894 1.0152558112202916 1.6809476463533077e-18 0.9921216603548992 0.03508011494447593 0.11003841156994117 0.1327135541374763 0.03958988411035613 0.07743520938310215 1.3278317872809253e-08 7.876856938885771 -1.0152558112202916 down SK(ub)NPDDLQEANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKNPDDLQEANK 12 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 16855400.0 2844500.0 6356500.0 7654400.0 True False 3729167.0461771875 5408134.97744293 6862396.114189437 1.0 1.4502259916157074 1.8401954187662788 21.83042199268772 -6.9728044622140635 0.17893628726702396 0.6942496361909045 2.6067061257432296 0.9999968025845057 0.0006138425423436292 0.07540279652343311 0.005636324850807548 0.015159521054888676 0.04390563697525828 1.0646222483979967e-07 6.9728044622140635 1.912456489552325 SK(ub)NPDDLQEANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKNPDDLQEANK 12 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 17675800.0 2225900.0 3582100.0 11867800.0 True False 2155240.0228960584 5012451.210404721 8759267.153631588 1.0 2.3257044028299667 4.064172463659759 21.03941711639216 -6.967394499992435 0.31425591440514383 0.745284997574002 5.70019523870647 0.9999543368815513 0.00847870928983388 0.07715755453603139 0.01204211340294023 0.026993337215973186 0.1537195878458352 1.0779670846136153e-07 6.967394499992435 4.954910241132468 SK(ub)NPDDLQEANK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKNPDDLQEANK 12 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 33241400.0 5926000.0 11703500.0 15611900.0 True False 8990175.248631353 9614918.985137139 12526201.122061146 1.0 1.069491830718305 1.393321128413833 23.099917808297167 -6.941388154307437 0.6465237340816883 0.9964343247200248 1.4843321513083316 0.9983400888969912 0.00698310358115981 0.08713908250080332 0.05176898186858354 0.0068712625784673 0.027705334329069603 1.1444895871049126e-07 6.941388154307437 0.4878978265883068 SK(ub)NPDDLQEANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKNPDDLQEANK 12 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 17125800.0 2844500.0 5476900.0 8804400.0 True False 3896188.5197221404 5234912.448313677 6724982.052309842 1.0 1.3435983453611244 1.7260412370368154 21.893632054210613 -6.969741642482525 0.26428190478445035 0.8980894957487393 2.18296054134673 0.9999802973911729 0.001316286553904845 0.07638661974525758 0.009329585319000397 0.007768170300715462 0.035857329145957004 1.0721569311774413e-07 6.969741642482525 1.2848710455979908 SK(ub)NPDDLQEANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKNPDDLQEANK 12 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 21935500.0 2225900.0 13122200.0 6587400.0 True False 1850934.4740896425 13051508.104047222 7964794.88330371 1.0 7.051307481031403 4.3031209342087 20.819822391826435 -9.496597534634146 9.31164319466034 1.0001145930722586 5.677214207620654 0.7943265465251858 1.1219424615668976 0.0 0.0 1.086316148752483 0.3621053721271493 3.1871497195109954e-10 9.496597534634146 4.677099614548395 SK(ub)NPDDLQEANK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKNPDDLQEANK 12 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 23271100.0 5926000.0 14345300.0 2999800.0 True False 7671323.81892371 13546971.44446783 2453867.1805472677 1.0 1.7659235569029175 0.31987532249571315 22.871044130389617 -6.762763843808469 1.6018145960595016 1.4433392300260672 0.3137995095520582 0.7023036473907124 0.3222912984230967 0.27826567146080444 1.4077252205412618 0.15869885930103672 0.3803833403239437 1.726776605587149e-07 6.762763843808469 -1.129539720474009 SK(ub)NQENGPVCSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKNQENGPVCSLR 13 1 Q6JHV3;H0YMI4;Q9Y6I4;H0YLB7;H0YKU8;Q9Y6I4-2 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 1 5080200.0 1609300.0 2427700.0 1043200.0 True False 2109807.8844833663 2065496.6231004817 935259.6710810018 1.0 0.9789974899094971 0.4432913906329538 21.00868020488138 -6.9151688119599095 0.8597868650105319 1.0140001821238613 0.3658222323448627 0.9927303989144279 0.021965809890837594 0.10109866489198621 0.12095902937260693 0.018456582391993298 0.05297236016587652 1.2157133562671726e-07 6.9151688119599095 -0.6481779497789986 down SK(ub)NQENGPVCSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKNQENGPVCSLR 13 1 Q6JHV3;H0YMI4;Q9Y6I4;H0YLB7;H0YKU8;Q9Y6I4-2 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 1 8875500.0 2665000.0 1761400.0 4449100.0 True False 3449895.0350036602 1663376.5416049627 3639409.451621063 1.0 0.4821527973250925 1.0549333862898822 21.718121037074873 -6.668590160435168 1.9423396487359885 0.6690609638685067 1.0526059419015315 0.27282828745944 0.22004182719345958 0.4643634507654954 3.3761183295967974 0.09124575606528285 0.24423759103235027 2.1449137810416094e-07 6.668590160435168 0.3835449780330248 SK(ub)SAVLHSQSSSSSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKSAVLHSQSSSSSSR 16 1 Q86WJ1;Q86WJ1-2;Q86WJ1-4;A0A0A0MSH9;A0A494C1P7;Q86WJ1-3;Q86WJ1-5;A0A0A0MRH8;A0A494C179 Q86WJ1 CHD1L Chromodomain-helicase-DNA-binding protein 1-like 1 2807220.0 728130.0 1149100.0 929990.0 True False 705015.9117082113 1607941.622477338 686397.7198980298 1.0 2.2807167835139945 0.9735918133179849 19.427296292917717 -6.650817123094237 2.005391992983483 1.830507758802687 0.9790599098021752 0.19747189671805743 0.5465116397265829 0.5065222977842773 3.9053853756562074 0.22093363194475907 0.605442199747768 2.23451295499958e-07 6.650817123094237 -0.8514478490005118 SK(ub)SAVLHSQSSSSSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKSAVLHSQSSSSSSR 16 1 Q86WJ1;Q86WJ1-2;Q86WJ1-4;A0A0A0MSH9;A0A494C1P7;Q86WJ1-3;Q86WJ1-5;A0A0A0MRH8;A0A494C179 Q86WJ1 CHD1L Chromodomain-helicase-DNA-binding protein 1-like 1 2857930.0 852060.0 1086200.0 919670.0 True False 1167089.6080557022 1038208.0924169363 702462.8871981952 1.0 0.8895701626086154 0.6018928472582787 20.15448390340677 -6.954573567300366 0.5061518087787569 1.0054665626091481 0.4734581304955727 0.9995130306429297 0.0037031267576187123 0.08169959167344482 0.02875197713972813 0.004294168200264425 0.023737181233167714 1.1102644461917973e-07 6.954573567300366 -0.5320084321135754 SK(ub)SAVLHSQSSSSSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKSAVLHSQSSSSSSR 16 1 Q86WJ1;Q86WJ1-2;Q86WJ1-4;A0A0A0MSH9;A0A494C1P7;Q86WJ1-3;Q86WJ1-5;A0A0A0MRH8;A0A494C179 Q86WJ1 CHD1L Chromodomain-helicase-DNA-binding protein 1-like 1 3034590.0 728130.0 1618700.0 687760.0 True False 605472.3566282815 1609979.7418132075 831567.4361570524 1.0 2.659047476219669 1.3734193263385892 19.207701568351993 -6.581893470111783 2.2600454678886615 2.1285060781640777 1.3767461964603176 0.0 0.7204036716042768 0.6936513989207479 6.667167576038761 0.2673798783440064 0.8046416053246424 2.61882531192233e-07 6.581893470111783 -0.7517598817037601 SK(ub)SGQDPQQEQEQER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKSGQDPQQEQEQER 15 1 Q9BZE9;Q9BZE9-2;J3QL04;J3KRY8;Q9BZE9-3;J3QR12;Q9BZE9-4 Q9BZE9 ASPSCR1 Tether containing UBX domain for GLUT4 1 2043210.0 628380.0 717630.0 697200.0 True False 608432.4208578212 1004183.4013910108 514582.4044483346 1.0 1.6504436104427591 0.8457511250351046 19.21473750482433 -6.691635641104701 1.860238751959623 1.407174217902289 0.8484566726563448 0.37806356495517823 0.27500444173890787 0.41327100646498816 2.773914863894364 0.11819767293639262 0.3072032868746443 2.034062807587726e-07 6.691635641104701 -0.5587175452459442 SK(ub)TEDHEEAGPLPTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKTEDHEEAGPLPTK 15 1 Q9BXS4;Q5T6Z8 Q9BXS4 TMEM59 Transmembrane protein 59 1 24390900.0 8126900.0 7106800.0 9157200.0 True False 12329101.45597401 5838536.014318157 7347275.406256665 1.0 0.4735573014113791 0.5959295113673166 23.555564324272872 -9.93817798569408 6.95452477244756 1.0000000191966325 0.5347434063894336 0.9506742677618005 0.04995824551480273 1.4940785114869227e-08 2.280175060087439e-09 0.04837186538352644 0.016123954407046774 1.1529806381480534e-10 9.93817798569408 -0.4652566128071989 SK(ub)TEDHEEAGPLPTK(ub)VNLAHSEI ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKTEDHEEAGPLPTKVNLAHSEI 23 2 Q9BXS4;Q5T6Z8 Q9BXS4 TMEM59 Transmembrane protein 59 2 68679000.0 14867000.0 25990000.0 27822000.0 True False 19490780.972232807 22112393.308226533 24943246.327468984 1.0 1.1345052483904343 1.2797458635959191 24.21628856302664 -6.970145117467376 0.25469618566005814 0.9564902250356083 1.4620404321643006 0.9999834900895738 0.0004641233064430744 0.07625564088132507 0.008861504579816753 0.003139020260016205 0.013815637743287474 1.0711613218921254e-07 6.970145117467376 0.5055502071286923 SK(ub)TEDHEEAGPLPTK(ub)VNLAHSEI ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKTEDHEEAGPLPTKVNLAHSEI 23 2 Q9BXS4;Q5T6Z8 Q9BXS4 TMEM59 Transmembrane protein 59 2 35539200.0 12669000.0 15538000.0 7332200.0 True False 12266829.529659992 21742404.429599542 5411676.85871497 1.0 1.7724550893145241 0.44116345186260764 23.54825908412645 -6.7494040718823785 1.6521512042634015 1.454534665899586 0.43865236970253124 0.6463790786331569 0.3245803717942263 0.3010770841251694 1.6167674004659838 0.15521034607415024 0.37702991074847336 1.7807211958401134e-07 6.7494040718823785 -1.0158822961970546 SK(ub)TEDHEEAGPLPTK(ub)VNLAHSEI ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKTEDHEEAGPLPTKVNLAHSEI 23 2 Q9BXS4;Q5T6Z8 Q9BXS4 TMEM59 Transmembrane protein 59 2 53570000.0 14867000.0 27069000.0 11634000.0 True False 20363731.665568303 25873002.074787363 8886288.809751127 1.0 1.2705432628801687 0.4363782117978096 24.279498624549532 -6.819382146995301 1.3745056195006509 1.1459159719285799 0.41840280695063586 0.8829561711819918 0.11887943748127827 0.19429221369925487 0.7214328286640039 0.06796715103195101 0.1566827847181276 1.5157160625669201e-07 6.819382146995301 -0.727513164977944 down SK(ub)THAVLVALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKTHAVLVALK 11 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 1 11626100.0 3427500.0 4447500.0 3751100.0 True False 4493485.691957215 3783950.3362192153 3362972.1550919735 1.0 0.8420968921726 0.7484105626754924 22.099403577659547 -13.999999999994783 0.05498573692506095 2.0658406764141346 0.2708163098414885 0.9999659584429056 0.0006057131126217058 12.515216535304829 0.0580066596028457 1.9223346935584413 0.45227343063884323 1.000000000012013e-14 13.999999999994783 -1.7950243665726462 SK(ub)THAVLVALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKTHAVLVALK 11 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 1 25655900.0 5136400.0 7929500.0 12590000.0 True False 4973347.793523218 11095790.701796219 9292301.308095993 1.0 2.231050624741396 1.8684197634835316 22.245785893778017 -10.053235549622288 4.945218009720262 0.9999789593640297 2.0497351941155446 0.9178507958925648 0.1480434292087517 3.563751887931599e-05 6.823419974160593e-06 0.14334540664006967 0.04778081131567453 8.846356771419094e-11 10.053235549622288 1.049756234751515 SK(ub)THAVLVALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKTHAVLVALK 11 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 1 14533100.0 2594900.0 5553400.0 6384800.0 True False 3936653.012600995 4562352.381087758 5122841.481442746 1.0 1.1589419657978328 1.3013190304161508 21.908538124325283 -6.97242916569341 0.19147315593961603 0.9053426388843554 1.558813853597598 0.9999956481509285 0.0002566827370083891 0.07552210188870796 0.006119020045211842 0.004963919350916322 0.015457867145918703 1.0655426416509808e-07 6.97242916569341 0.6534712147132425 SK(ub)THAVLVALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKTHAVLVALK 11 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 1 11454300.0 3427500.0 4023300.0 4003500.0 True False 4694739.374704736 3845537.3027260676 3057955.7546706726 1.0 0.8191162481661557 0.6513579371726029 22.16261363918244 -6.972030249225737 0.2039458754729858 1.0949082799947547 0.3709141357205023 0.9999941861487059 0.0003432236828239141 0.0756492650482756 0.00661743947232581 0.005273741309510958 0.017635789772679218 1.0665218338869794e-07 6.972030249225737 -0.7239941442742523 SK(ub)THAVLVALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKTHAVLVALK 11 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 1 23088900.0 5136400.0 15025000.0 2927500.0 True False 4271144.181101601 14944057.342771 3539626.7147693564 1.0 3.498841694198362 0.8287303272109223 22.026191169212293 -6.661095247851044 1.968665208234743 2.607050750588539 0.8397851651263403 0.24026717996734792 1.0636795530491208 0.4819488824722576 3.591730200769261 0.43630980355995547 1.1795333292279797 2.1822512561246413e-07 6.661095247851044 -1.7672655854621988 SK(ub)VDDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKVDDLR 7 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 127189000.0 63987000.0 30563000.0 32639000.0 True False 97072957.07630344 25108793.8601911 26187887.34381811 1.0 0.2586589985144321 0.2697753126365907 26.53256610480113 -10.046515908119943 5.15689644411366 1.0000088573528028 0.26421715557320447 0.9998288369832975 0.004538216245115803 4.647453896452931e-07 8.592930505224388e-08 0.004394162130746914 0.0014647029936814117 8.984296826685028e-11 10.046515908119943 -0.7357917017795983 SK(ub)VDDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKVDDLR 7 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 119391000.0 63987000.0 26447000.0 28957000.0 True False 82832432.87233737 24975201.20121856 23687123.123910684 1.0 0.30151476100805497 0.28596435360552125 26.30369242689358 SK(ub)VTAPLECSFLLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKVTAPLECSFLLLK 15 1 E9PJD7;Q6ZMK1-2;Q6ZMK1 E9PJD7 CYHR1 Cysteine and histidine-rich protein 1 1 33247000.0 4563400.0 9165600.0 19518000.0 True False 5907411.258062167 8655526.302790068 15965924.271591974 1.0 1.4651978548094815 2.702693883010499 22.494094621324354 -6.954117777387025 0.5116452654659929 0.9775295474406068 3.244805461987752 0.9994860628928511 0.016289911695253265 0.08187319397556249 0.029436435955149304 0.018709943089111725 0.10214512061248013 1.1114302749020925e-07 6.954117777387025 2.2672759145471453 SK(ub)WDEEWDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKWDEEWDK 9 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 22809800.0 11364000.0 7743400.0 3702400.0 True False 14898314.04913256 6588114.903536798 3319311.1639285856 1.0 0.44220539866525266 0.22279777114255753 23.828645743182502 -11.491000688205691 0.16952492830375993 2.210525289657851 3.373492760126544e-19 0.9995213630497536 0.007157585004383596 4.151758888007672 0.10446441086755819 2.0278353388531642 0.17331664998983023 3.2284890056764877e-12 11.491000688205691 -2.210525289657851 SK(ub)WDEEWDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKWDEEWDK 9 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 28866100.0 15902000.0 8236400.0 4727700.0 True False 15397199.714314738 11525237.472258588 3489373.5420401427 1.0 0.7485281535670154 0.2266239060857333 23.87616465632508 -7.074711585034131 0.47958856624915 1.01269030311502 1.0938661921688662e-10 0.9996185143248754 0.00629113446366296 0.07469799679045537 0.026322556330224314 0.007791913899142433 0.03992433004044674 8.419540977404369e-08 7.074711585034131 -1.0126903030056333 down SK(ub)WDEEWDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKWDEEWDK 9 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 20619400.0 10594000.0 4696800.0 5328600.0 True False 16071872.525143517 3858619.3437341014 4275399.874391649 1.0 0.24008523821337646 0.2660175326616754 23.93803469063327 -10.279980421725146 5.578830638731067 1.000071849449057 0.25305138543766986 0.9990968301947757 0.010586814876381712 9.461826354393787e-06 1.2211745662962209e-06 0.010251616555498624 0.003416879808792159 5.248311194412473e-11 10.279980421725146 -0.7470204640113871 SK(ub)WDEEWDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKWDEEWDK 9 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 22707600.0 11364000.0 7879400.0 3464200.0 True False 15565577.900552789 7531262.054308605 2646027.307438528 1.0 0.4838408250837345 0.16999223057080062 23.891855804705393 -8.481014957539184 0.2934928597408064 1.1812288648751688 7.240260096264786e-14 0.9988760153859408 0.011472154935838919 0.1617895587230979 0.07937154812997078 0.11901375664456407 0.09873463587638993 3.303581629731581e-09 8.481014957539184 -1.1812288648750964 SK(ub)WDEEWDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKWDEEWDK 9 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 31696800.0 15902000.0 11473000.0 4321800.0 True False 13223217.578046426 11411192.671787798 5225468.398254549 1.0 0.8629664152795152 0.39517374401598176 23.656569931759357 -6.948516178547019 0.5749020511535661 1.0057051667969557 0.22949891618426452 0.9990796439454217 0.0078553852683327 0.08408707991333009 0.038470696892021115 0.00827651125109065 0.03902451282743864 1.125858527090122e-07 6.948516178547019 -0.7762062506126911 down SK(ub)WDEEWDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKWDEEWDK 9 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 18433800.0 10594000.0 3696300.0 4143500.0 True False 13714141.838960128 3490597.6556911618 3389425.5159002673 1.0 0.2545254159304973 0.24714820334374416 23.70916101272572 SK(ub)WDEEWDKNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKWDEEWDKNK 11 2 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 75520200.0 47739000.0 7616200.0 20165000.0 True False 72423553.18839207 6257029.604357799 16179378.911366519 1.0 0.08639495480264099 0.22339940805278968 26.10995562315104 -10.75098079744363 6.857102381296775 1.0165714069785945 0.15489718142776518 0.9806698877668543 0.055931833825309446 0.013520997404933767 0.0004910212723859628 0.05167642886337668 0.01805192174402201 1.77426792933503e-11 10.75098079744363 -0.8616742255508293 SK(ub)WDEEWDKNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKWDEEWDKNK 11 2 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 14817700.0 9456800.0 3816400.0 1544500.0 True False 12953234.52041071 3647778.8288528733 1179720.9099759834 1.0 0.2816114247839012 0.09107539187351778 23.626809058948595 -11.481081840409914 0.24055646888209017 2.304863017767183 9.296128066676958e-14 0.9992761129821781 0.0105298502690054 4.021822110284744 0.13862090525282972 2.8253040135369973 0.0916955234672112 3.303072905768011e-12 11.481081840409914 -2.30486301776709 SK(ub)WDEEWDKNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKWDEEWDKNK 11 2 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 85548000.0 47739000.0 10700000.0 27109000.0 True False 61799076.576375015 10104535.593944067 22175440.161829416 1.0 0.1635062553314413 0.3588312542894338 25.88108194524349 -10.77157687910173 10.353485704968088 1.0031883775040265 0.2611687553728883 0.9501921431577524 0.07974109690945626 0.005860141251351344 0.0001292888041958144 0.07709660559257467 0.02573632836155298 1.69208868324443e-11 10.77157687910173 -0.7420196221311381 SK(ub)YFTCQCGSEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKYFTCQCGSEK 12 1 A0A0G2JRR0;A0A0G2JRN8;A0A0G2JIS2;A2ABF8;A0A0G2JIR1;A2ABF9;A0A0G2JK64;Q96KQ7-2;Q96KQ7 A0A0G2JRR0 EHMT2 Histone-lysine N-methyltransferase EHMT2 1 11821400.0 4245900.0 3588300.0 3987200.0 True False 5496401.249201515 3388607.9506307975 3261570.512126832 1.0 0.6165139328434355 0.5934010935974978 22.39005589718887 -13.999999999999998 0.3996689931168788 7.450598884541301 0.5920337654253629 0.9998372995696074 0.002378413676407357 26.72219950186489 0.20832248849169832 149.46413367814083 0.005919567834436741 1.0000000000000041e-14 13.999999999999998 -6.858565119115938 SK(ub)YIHPDDELVLEDELQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKYIHPDDELVLEDELQR 18 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7;C9IZD2 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 19701100.0 3095800.0 6179900.0 10425400.0 True False 4058623.7797698444 5257883.009061531 9346679.615498345 1.0 1.2954842070529864 2.302918457750813 21.952559182772927 -6.948544820633452 0.5745959298317334 0.9876977974026565 2.6600738706727585 0.9990820948328644 0.016898320823973283 0.08407535930355119 0.038421403164282476 0.017810295954261656 0.08403621399573451 1.1257842782215426e-07 6.948544820633452 1.6723760732701018 up SK(ub)YIHPDDELVLEDELQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKYIHPDDELVLEDELQR 18 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7;C9IZD2 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 61260800.0 4976500.0 3143300.0 53141000.0 True False 4818523.731498378 4398436.082092949 39221777.90417232 1.0 0.9128181839887302 8.139791373814784 22.200159779789566 -6.904169718768366 0.9345231088060532 0.7329284006642148 8.966057695461995 0.9885292421785357 0.36269599924447987 0.10840101936057966 0.16061253272585455 0.2886372959929617 0.7679881804852629 1.2468961420985947e-07 6.904169718768366 8.23312929479778 up SK(ub)YIHPDDELVLEDELQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKYIHPDDELVLEDELQR 18 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7;C9IZD2 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 404182100.0 12109100.0 72283000.0 319790000.0 True False 18370389.993790384 59383533.900343284 256583366.3310637 1.0 3.232567948770619 13.967224779538963 24.130878918648552 -6.940681453063401 0.6531930059278341 0.8807781090266525 16.920990124261596 0.9982518027537728 0.23667156885011983 0.08745712286556874 0.053204196340286586 0.23158930084734441 0.9211715797943548 1.146353462128671e-07 6.940681453063401 16.040212015234943 SK(ub)YIHPDDELVLEDELQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKYIHPDDELVLEDELQR 18 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7;C9IZD2 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 26335500.0 3095800.0 4742900.0 18496800.0 True False 4240400.920849283 4533342.99532709 14128236.793553764 1.0 1.0690835795826437 3.3318162733358023 22.015769244295818 -6.913414148680204 0.8721565062668645 0.937277482579422 3.6466471798255817 0.9921475741408146 0.09599658464122478 0.10220354827827678 0.1268391928154766 0.07994525815973785 0.22627341186207967 1.2206350920036487e-07 6.913414148680204 2.7093696972461596 up SK(ub)YIHPDDELVLEDELQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKYIHPDDELVLEDELQR 18 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7;C9IZD2 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 45103600.0 4976500.0 8551100.0 31576000.0 True False 4138180.246330523 8505033.527039537 38178395.609071545 1.0 2.0552593219160196 9.22588996526329 21.980565055223842 -6.9332621344186105 0.7195110332350295 0.903049538417465 10.828233887115312 0.9971414352666634 0.19538858182234262 0.090979060738043 0.069639127674013 0.18159733568820477 0.6375807796434105 1.1661055586741131e-07 6.9332621344186105 9.925184348697847 SK(ub)YIHPDDELVLEDELQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKYIHPDDELVLEDELQR 18 1 A0A087WWF6;P49005;F8W8R3;C9JLE1;C9J8Z7;C9IZD2 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 469239100.0 12109100.0 22620000.0 434510000.0 True False 15675468.65604607 21361177.11542192 355433638.449095 1.0 1.3627137780778795 22.674514315844924 23.902005240741 -6.910593344135049 0.8916738116749247 0.3524609489586117 25.46404981726412 0.9911437976967791 0.9535953035222038 0.10402724986872047 0.13664472113662465 0.7830186396443918 2.170505331703436 1.2285890940873545e-07 6.910593344135049 25.111588868305507 up SK(ub)YNDDIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKYNDDIR 8 1 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 3042700.0 0.0 1592200.0 1450500.0 True False 0.0 2227973.763213312 1070570.535932744 0.0 SK(ub)YNDDIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKYNDDIR 8 1 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 4718000.0 1193600.0 1264700.0 2259700.0 True False 1810778.4638485294 1039004.403853798 1813069.3045383058 1.0 0.5737888011135028 1.00126511372623 20.78817862270376 -10.907595398951013 10.629777868143806 1.0221341808367412 0.7875269574198664 0.24778039854183698 0.17451647383794178 0.07818157657137678 0.0006796309536691847 0.1443113182358598 0.05632494973443258 1.2370994136305862e-11 10.907595398951013 -0.2346072234168748 SK(ub)YNDDIRK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKYNDDIRK 9 2 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 5602100.0 1497400.0 2374800.0 1729900.0 True False 1963105.9008422266 2020489.0968978968 1550906.5423725303 1.0 1.0292308204213798 0.7900269372666796 20.904706571215808 -6.876335186626943 1.1000970274788406 1.0173688035479276 0.7742264628888219 0.9706042555632979 0.01826690008286045 0.13092284978546118 0.29236047893380185 0.012830954128340242 0.03075788193648712 1.3294279750916472e-07 6.876335186626943 -0.24314234065910567 SK(ub)YNDDIRK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKYNDDIRK 9 2 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 5780700.0 2169600.0 2011200.0 1599900.0 True False 2100727.235578998 2814282.648269444 1180838.194028815 1.0 1.3396706629044 0.5621092419946443 21.002457419852973 -6.7879767098714225 1.504486575128826 1.1903415410307234 0.5543028609429943 0.7946829935385138 0.1442193166893082 0.23837831377180474 1.0659698436091818 0.0754630446160216 0.1769353803842889 1.6293834100602946e-07 6.7879767098714225 -0.6360386800877291 SK(ub)YNDDIRK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKYNDDIRK 9 2 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 4632120.0 971420.0 1205600.0 2455100.0 True False 1473715.1603147916 990451.2606042067 1969848.4088914455 1.0 0.6720778121008419 1.3366547769452801 20.491026276585057 -6.772516366297442 1.5646583788193906 0.8125212292519415 1.34076947771287 0.7401675706703237 0.13830211851412913 0.2623700213812018 1.2679546056486208 0.0696556564932352 0.16544064999640115 1.688432230069561e-07 6.772516366297442 0.5282482484609285 SK(ub)YNDDIRK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKYNDDIRK 9 2 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 6172600.0 1497400.0 2226200.0 2449000.0 True False 2051029.245713456 2127839.122941063 1870596.6387382236 1.0 1.037449430517939 0.9120282622237946 20.9679166327387 -6.826664887650905 1.3426121590122013 1.0200615767912342 0.9088743123632537 0.8990652267508864 0.016701446924445182 0.1849617265521815 0.6532103637866034 0.009769885356099333 0.02249032762890611 1.490510749005298e-07 6.826664887650905 -0.11118726442798055 SK(ub)YNDDIRK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKYNDDIRK 9 2 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 5071230.0 2169600.0 2081000.0 820630.0 True False 1804118.5295767516 2069789.2399538388 992219.9388355856 1.0 1.1472579024169847 0.5499749171515697 20.78286269528725 -6.841490675898418 1.275526191774993 1.0783267558300598 0.5297517195583118 0.9269759487030819 0.06865667061806685 0.167065029532804 0.5273579435331709 0.04219689927920836 0.09725180414230397 1.4404869365024133e-07 6.841490675898418 -0.548575036271748 SK(ub)YNDDIRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKYNDDIRK 9 2 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 1 2404840.0 971420.0 857060.0 576360.0 True False 1257522.339550938 809363.8575837098 471468.39395300474 1.0 0.6436178763016919 0.37491850373120716 20.262152598677506 -7.772590080926516 0.19828936226137525 1.2287283821361443 1.0120957085088415e-15 0.9998999293719676 0.0025611371330419774 0.12770346062061366 0.02721537652243146 0.05521158167167699 0.08830076948003628 1.6881456696857712e-08 7.772590080926516 -1.2287283821361432 down SKDDQVTVIGAGVTLHEALAAAELLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKDDQVTVIGAGVTLHEALAAAELLK 26 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 131476700.0 24973000.0 96611000.0 9892700.0 False True 37885866.770852275 79370012.22481175 7937403.508875551 1.0 2.094976807706972 0.20950829914711733 25.175156419142503 -6.74925442319121 1.6525163560926908 1.6444309254332214 0.20595353978114483 0.6457902496113834 0.46010126637501325 0.30134879117331254 1.6188623559462783 0.21996140880340587 0.5344438928984742 1.7813349004226178e-07 6.74925442319121 -1.4384773856520767 SKDDQVTVIGAGVTLHEALAAAELLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKDDQVTVIGAGVTLHEALAAAELLK 26 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 49438300.0 24973000.0 17902000.0 6563300.0 False True 32328040.791424513 16905737.962877247 5368846.745144975 1.0 0.5229434741174214 0.16607399068146253 24.946282741234953 -8.07771448791856 0.33569175833433024 1.103102151759769 7.621952356793304e-22 0.998624022283491 0.012672311315636923 0.09333597818792673 0.0720595000308298 0.06052950423571541 0.08824649921941707 8.361525375218233e-09 8.07771448791856 -1.103102151759769 down SKEFAQIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKEFAQIIK 9 1 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 32784500.0 2451000.0 27419000.0 2914500.0 False True 3718346.1921018297 22525865.2243752 2338447.7975292676 1.0 6.058033346174861 0.6288945882705553 21.826229666202725 -6.662087266356537 1.9653629230796115 4.250208367174016 0.6513992933628402 0.2445138464027894 2.152531976876587 0.47954895631097577 3.5629589418874237 0.8841603581810007 2.3869521867087684 2.1772722312067778e-07 6.662087266356537 -3.598809073811176 SKFDNLYGCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKFDNLYGCR 10 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 11007700.0 1372700.0 6220700.0 3414300.0 False True 1799622.9932457109 5292595.808098686 3061020.988278244 1.0 2.940946980541309 1.7009234710640913 20.77926327435535 -10.251460555123709 5.506762228268471 0.9999002679071699 2.3209352258027414 0.6020709027390986 0.5062374778792895 0.0006199225729590304 8.426474530559617e-05 0.4901985367531624 0.1633874434210132 5.60453318328446e-11 10.251460555123709 1.3210349578955713 SKFDNLYGCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKFDNLYGCR 10 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 35444800.0 7019800.0 23792000.0 4633000.0 False True 10649549.816122554 19546131.71225555 3717285.5192839634 1.0 1.8353951152624584 0.3490556486863224 23.344289109519472 -6.754182583721636 1.6342161889328197 1.4887313631970014 0.3451036448955378 0.6668457007786717 0.35113728274393374 0.29279711269828884 1.5396773879565662 0.16964277286046 0.41007889918259727 1.761235441726394e-07 6.754182583721636 -1.1436277183014636 SKFDNLYGCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKFDNLYGCR 10 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 9550800.0 1372700.0 3800900.0 4377200.0 False True 1880224.2858226688 3632963.6701045223 3343395.5112637617 1.0 1.9321969711262208 1.7781897279349843 20.842473335878243 -10.09864462749927 4.392967404159846 0.9999066689258677 1.8551933495906547 0.9762546780730712 0.06287319396333715 9190182.163134282 7042200.571778722 7352.705360327475 0.021523167335759968 7.968110946630532e-11 10.09864462749927 0.8552866806647871 SKGGVVGIK(ub)VDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKGGVVGIKVDK 12 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 11028600.0 2441800.0 3824800.0 4762000.0 True False 3201223.4464248377 3254154.748953628 4269273.920329501 1.0 1.0165347103739055 1.333638214195099 21.610191950299566 -6.917702548077259 0.8415963923905656 0.9924073323011798 1.38216513035102 0.9935184455812481 0.012360388228219 0.09954244133702093 0.11276017109841928 0.010522156302036647 0.030858415093932084 1.2086413602607155e-07 6.917702548077259 0.38975779804984023 SKGGVVGIK(ub)VDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKGGVVGIKVDK 12 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 328343000.0 44947000.0 95516000.0 187880000.0 True False 68187885.06585106 78470423.53008585 150745435.64927068 1.0 1.150797146066411 2.2107363427343634 26.023012102757225 -6.93258587880592 0.7252548117655623 0.9853267438744946 2.4433927574316487 0.9970224867296211 0.029396791922552862 0.09131711616971029 0.07126478876556998 0.027206373663268744 0.09457940789766706 1.1679227581738679e-07 6.93258587880592 1.4580660135571542 up SKGGVVGIK(ub)VDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKGGVVGIKVDK 12 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 11328300.0 2441800.0 2993800.0 5892700.0 True False 3344599.4471638305 2861524.0168273062 4500965.623965996 1.0 0.8555655354346946 1.34574130477201 21.673402011822457 -6.827811323939643 1.337822355191956 0.9227010403978283 1.3583366597170172 0.9013931876095854 0.06458131740532282 0.1835297623609627 0.6432052151166876 0.037912261713274095 0.08725110352748038 1.4865813364040557e-07 6.827811323939643 0.4356356193191889 SKGGVVGIK(ub)VDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKGGVVGIKVDK 12 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 311287000.0 44947000.0 143710000.0 122630000.0 True False 58184777.5378272 135712412.1687571 100312598.29005656 1.0 2.33243844716133 1.7240350919076923 25.794138424849674 -9.89467554283144 5.451595449559364 0.9999990310284078 2.02823676954011 0.7920303244890978 0.24837962971445532 2.925304429933802e-06 5.929327798769585e-07 0.24049276807788278 0.08016418078225361 1.274454858226106e-10 9.89467554283144 1.0282377385117023 SKGGVVGIKVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKGGVVGIKVDK 12 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 15390310.0 8177200.0 552110.0 6661000.0 False True 10720388.388117444 469737.3401079235 5971783.616823761 1.0 0.04381719421924898 0.5570491852182267 23.35385383824051 -10.610713329697587 6.434292585440737 1.0021879876213158 0.30043318971873784 0.7124163525009222 0.2095260829366974 0.006589981931775773 0.00039870572740430266 0.2032929740122539 0.06762425248415858 2.4506803599381105e-11 10.610713329697587 -0.701754797902578 SKGGVVGIKVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKGGVVGIKVDK 12 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 10524020.0 909720.0 6215500.0 3398800.0 False True 1380111.749440585 5106295.463076849 2727025.69025304 1.0 3.69991449253775 1.9759455648127142 20.396353657948247 -10.276819552743088 6.151141169676942 0.9999345449668788 2.837930028675234 0.6024547232003645 0.7038073675565722 0.000631787067816067 7.427797712899502e-05 0.6814822297836021 0.2271528511237226 5.286648638423618e-11 10.276819552743088 1.837995483708355 SKGGVVGIKVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKGGVVGIKVDK 12 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 8276220.0 909720.0 2726100.0 4640400.0 False True 1177650.4732621112 2574390.1385655073 3795894.814524822 1.0 2.18603923406442 3.223277959554613 20.167479980040696 -6.972698104046676 0.18257730285886029 0.22503434425269978 5.212404149683761 0.9999964974303958 0.0016999377137996417 0.07543656318207431 0.005774701591917075 0.03904635723383284 0.11550326437919463 1.0648830049635256e-07 6.972698104046676 4.987369805431061 SKGPVSLLSLWSNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKGPVSLLSLWSNR 14 1 Q9NVM9;Q9NVM9-2;H0YH12 Q9NVM9 ASUN Protein asunder homolog 0 4047000.0 1508300.0 1278200.0 1260500.0 False True 1977395.9063979785 1087497.5423845777 1130075.5515697876 1.0 0.5499644956611454 0.5714968600437388 20.9151703200141 -10.07790124305086 5.07171515764948 1.0000092492950052 0.5607306778509621 0.9982011241177323 0.008790550954028415 9.193698381070412e-07 1.6715590184831475e-07 0.008511593470469505 0.0028371381200008204 8.357930528540115e-11 10.07790124305086 -0.43927857144404314 SKGPVSLLSLWSNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKGPVSLLSLWSNR 14 1 Q9NVM9;Q9NVM9-2;H0YH12 Q9NVM9 ASUN Protein asunder homolog 0 6235170.0 2312100.0 850370.0 3072700.0 False True 2238703.651079554 1189927.1756209661 2267867.6909759003 1.0 0.5315250971459112 1.0130271998628682 21.09423213305976 -10.91002532087311 11.403361661902723 1.0214483907903644 0.7722761485043901 0.2297237546417723 0.19657241028895303 0.08907887327054329 0.0007028479212303596 0.15817238097928468 0.06344347261441385 1.2301970439711863e-11 10.91002532087311 -0.24917224228597434 SKGPVSLLSLWSNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKGPVSLLSLWSNR 14 1 Q9NVM9;Q9NVM9-2;H0YH12 Q9NVM9 ASUN Protein asunder homolog 0 9495700.0 1508300.0 4159000.0 3828400.0 False True 2065959.2702748822 3975241.628026182 2924210.768372974 1.0 1.9241626324497985 1.4154251782436633 20.97838038153699 -10.288994998032898 5.005987149015229 0.9998152181594321 1.6697939053470052 0.6979928235403599 0.20769119597554375 0.00042843648673865153 6.0850974547403776e-05 0.20115068443449657 0.06703204526379568 5.1404957209108664e-11 10.288994998032898 0.6699786871875731 SKGPVSLLSLWSNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKGPVSLLSLWSNR 14 1 Q9NVM9;Q9NVM9-2;H0YH12 Q9NVM9 ASUN Protein asunder homolog 0 4617100.0 2312100.0 1029100.0 1275900.0 False True 1922613.593397127 1023556.0340396425 1542684.7909049408 1.0 0.5323774041517562 0.8023894121018473 20.874637408494035 -10.216640147650724 5.593712193330822 1.0000138055702885 0.667383408126787 0.669235662332598 0.11023194065039386 1.8979468569892728e-05 2.6577943487848137e-06 0.10673604520588147 0.03557720586325045 6.072392739800621e-11 10.216640147650724 -0.33263039744350154 SKIETEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKIETEIK 8 1 Q9HB71;B2ZWH1;Q9HB71-2 Q9HB71 CACYBP Calcyclin-binding protein 0 27314300.0 5800000.0 12769000.0 8745300.0 False True 7603856.167279904 10863914.973172149 7840420.246841144 1.0 1.4287375686984427 1.0311110671160768 22.858299811895257 -10.597250879241775 7.3798426184213275 0.999754892263624 1.2299243179072035 0.30835016391576986 0.16233033951412743 0.0006553354787626187 3.5764420179332075e-05 0.15734050425557022 0.052391891793534255 2.5278373167800166e-11 10.597250879241775 0.23016942564357945 SKIETEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKIETEIK 8 1 Q9HB71;B2ZWH1;Q9HB71-2 Q9HB71 CACYBP Calcyclin-binding protein 0 15962800.0 4668900.0 3061500.0 8232400.0 False True 4520688.325126647 4283972.915511588 6076087.473293842 1.0 0.9476373081728814 1.3440624604713531 22.108111025071263 -6.873632893720019 1.114641984166129 0.9696207741745982 1.368945959008481 0.9681791061246707 0.031366858884766056 0.13342213296294195 0.3076115121524247 0.021786883758744116 0.05193475542232081 1.337725809626343e-07 6.873632893720019 0.3993251848338827 SKIETEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKIETEIK 8 1 Q9HB71;B2ZWH1;Q9HB71-2 Q9HB71 CACYBP Calcyclin-binding protein 0 33994400.0 2852400.0 26599000.0 4543000.0 False True 4327299.338372606 21852200.631064426 3645074.0587323643 1.0 5.0498472424333185 0.8423438670880554 22.045035491112113 -6.654801395431062 1.9912119122991032 3.617768317875782 0.8598467501366976 0.21398442528978112 1.7264634677953898 0.49674736199461006 3.780437603984686 0.7018388496004485 1.9131255589399456 2.21410699793538e-07 6.654801395431062 -2.7579215677390843 SKIETEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKIETEIK 8 1 Q9HB71;B2ZWH1;Q9HB71-2 Q9HB71 CACYBP Calcyclin-binding protein 0 24003300.0 5800000.0 8356200.0 9847100.0 False True 7944416.73910649 7986995.453741847 7521417.787390434 1.0 1.0053595771764794 0.9467551910219112 22.92150987341815 -6.884545296892801 1.054085816730701 1.003572800247411 0.9422215753682028 0.9771721094314881 0.003996867227839708 0.12368171561847638 0.24858160632104434 0.002907815858451971 0.007120744009106557 1.3045318989319943e-07 6.884545296892801 -0.06135122487920808 SKIETEIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKIETEIK 8 1 Q9HB71;B2ZWH1;Q9HB71-2 Q9HB71 CACYBP Calcyclin-binding protein 0 9122700.0 4668900.0 3215100.0 1238700.0 False True 3882397.21734001 3197779.6181526175 1497706.4428983098 1.0 0.8236611142905021 0.3857684721720592 21.88851630050554 -6.955606202857773 0.493483895031125 1.0092872434588123 0.18146388813096773 0.9995709145079684 0.005348986901755088 0.08130977540412865 0.027228362548625963 0.006352619058572409 0.03611676600764642 1.1076276717450987e-07 6.955606202857773 -0.8278233553278446 down SKIETEIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKIETEIK 8 1 Q9HB71;B2ZWH1;Q9HB71-2 Q9HB71 CACYBP Calcyclin-binding protein 0 9464200.0 2852400.0 3996000.0 2615800.0 False True 3692488.0292099193 3773619.087233688 2139751.2403745423 1.0 1.0219719217454386 0.5794876580364661 21.816161813204562 -6.895220349024708 0.9910163025433382 1.020886243888291 0.5373019350863023 0.9840337692834339 0.025727399340707835 0.11500862328643775 0.1979360221813778 0.019632747679011 0.04995863075424269 1.2728571046172332e-07 6.895220349024708 -0.48358430880198877 SKIETEIK(ub)NK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKIETEIKNK 10 2 Q9HB71;B2ZWH1;Q9HB71-2 Q9HB71 CACYBP Calcyclin-binding protein 1 5014850.0 2405600.0 1734500.0 874750.0 True False 2329235.544758865 2427094.89529801 645626.7330625072 1.0 1.042013505572394 0.27718396042652954 21.15142510929063 -6.893911534550715 0.9989896794323373 1.0373252979644805 0.20613912889157668 0.9832849796959345 0.045387434758891086 0.11602557286574158 0.2037838572270095 0.03442869703250608 0.0871295739047841 1.2766988448908385e-07 6.893911534550715 -0.8311861690729038 down SKIETEIK(ub)NK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKIETEIKNK 10 2 Q9HB71;B2ZWH1;Q9HB71-2 Q9HB71 CACYBP Calcyclin-binding protein 1 8896000.0 2560800.0 3004200.0 3331000.0 True False 3884920.819557058 2468077.038078266 2672626.3899708376 1.0 0.6352966129074583 0.6879487418421977 21.8894537639941 -10.246276447394688 5.483342074646197 1.0000249159345354 0.661622677374907 0.982164919030129 0.021495141626956826 6.547815229834382e-06 9.000406422127834e-07 0.020814112039068217 0.00693752712878815 5.671834534505662e-11 10.246276447394688 -0.33840223855962837 SKIETEIK(ub)NK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKIETEIKNK 10 2 Q9HB71;B2ZWH1;Q9HB71-2 Q9HB71 CACYBP Calcyclin-binding protein 1 3263560.0 1170400.0 1361400.0 731760.0 True False 1603128.508870728 1301248.8464522348 558933.3590702658 1.0 0.8116934102612007 0.34865162460618226 20.612458647766974 -6.955815242935643 0.4908706579503597 1.0100538177925724 0.1306271384792475 0.9995821375057188 0.00559454005352703 0.08123128346247471 0.026923332817987564 0.006679363640493165 0.03819035116872881 1.1070946627620025e-07 6.955815242935643 -0.879426679313325 down SKIETEIK(ub)NK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKIETEIKNK 10 2 Q9HB71;B2ZWH1;Q9HB71-2 Q9HB71 CACYBP Calcyclin-binding protein 1 9634300.0 2560800.0 3213200.0 3860300.0 True False 3315006.0809145803 3034382.595370194 3157765.0100228796 1.0 0.9153475201267308 0.9525668831206731 21.66058008608655 -10.085795870717547 4.343349305561001 1.0000065161694323 0.9339572016729384 0.8076216417715887 0.015194741341256009 21123956.67158258 0.9508878420184972 1492.5456178436557 0.005201564113532645 8.207372207312523e-11 10.085795870717547 -0.06604931449649387 SKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICR 50 1 P68363;C9JDS9;P68366-2;P68366;Q71U36;Q71U36-2;F8VQQ4;Q9BQE3;F5H5D3 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 109125000.0 22880000.0 16237000.0 70008000.0 False True 34710632.7520562 13339380.48973995 56170888.1144036 1.0 0.3843024293168424 1.6182617158160602 25.048874329001634 -6.771057291583406 1.5705959177872992 0.6473284430277515 1.6254515188827603 0.7345286540925424 0.2595579550271659 0.26471903841667394 1.2888977935516386 0.13025642271294277 0.30974060086761385 1.6941143002718092e-07 6.771057291583406 0.9781230758550088 SKLTFSCLGGSDNFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKLTFSCLGGSDNFK 15 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 51544000.0 16332500.0 6137100.0 29074400.0 False True 21412065.664154995 5221468.602228431 26066059.989338096 1.0 0.24385636977423733 1.2173538227549034 24.351920646281467 -6.6993525719593645 1.8329330753491626 0.530179468326556 1.2144481972214989 0.41464100166070006 0.3192139549829651 0.3968580742779189 2.5916205646659183 0.13895355160805856 0.35767030709241177 1.998238986734175e-07 6.6993525719593645 0.6842687288949428 SKLTFSCLGGSDNFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKLTFSCLGGSDNFK 15 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 64359000.0 12625000.0 30361000.0 21373000.0 False True 19153048.01113243 24942842.338424295 17148617.18188131 1.0 1.3022910151912443 0.8953466399663346 24.191070664749766 -6.70779000018496 1.8031914184331999 1.1862606137593292 0.8963678538201575 0.45456139289756325 0.12742866780304893 0.37952911443352333 2.404172641244141 0.05626824609146639 0.1433263767897524 1.9597920870850132e-07 6.70779000018496 -0.28989275993917174 SKLTFSCLGGSDNFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKLTFSCLGGSDNFK 15 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 49926400.0 16332500.0 26605400.0 6988500.0 False True 22371066.619216673 25429885.455707524 5337960.2326754 1.0 1.1367310235383832 0.23861000119190157 24.41513070780436 -6.868080777974686 1.1441378735011907 1.0765081729507644 0.1878813056563125 0.9627331831867982 0.07627512355824903 0.13871169178083076 0.3405624619193306 0.05179421672911893 0.12223824302243501 1.3549373730535554e-07 6.868080777974686 -0.888626867294452 down SKLTFSCLGGSDNFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKLTFSCLGGSDNFK 15 1 Q15185-4;Q15185;A0A087WYT3;Q15185-3;Q15185-2 Q15185-4 PTGES3 Prostaglandin E synthase 3 0 80488900.0 12625000.0 32200000.0 35663900.0 False True 16343311.375955416 30408041.69392516 29173436.142516077 1.0 1.8605802088958567 1.7850382625296228 23.962196986842216 -10.096402680255839 4.489858243557928 0.9999305594901147 1.8228092357500627 0.9937179348411821 0.030839870632114994 10116137.839221308 1.1080125755724781 7546.354456953531 0.011128379729912525 8.009350875334139e-11 10.096402680255839 0.822878676259948 SKPFAFGNSSATGSLFGFSFNAPLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKPFAFGNSSATGSLFGFSFNAPLK 25 1 J3KNE0;A6NKT7;P49792 J3KNE0;P49792 RGPD3;RANBP2 RanBP2-like and GRIP domain-containing protein 3;E3 SUMO-protein ligase RanBP2 0 62090000.0 26268000.0 10692000.0 25130000.0 False True 25434136.71837624 14961371.358043399 18547699.11615983 1.0 0.5882397945605822 0.72924429563041 24.600262791506093 -10.380589765397854 5.308971591918197 1.0001756513308158 0.658742045095487 0.8864896826198296 0.05756484650949922 0.00011974088573905276 1.3970318895621e-05 0.05576535244148707 0.018578974321518414 4.163036653003475e-11 10.380589765397854 -0.3414336062353288 SKPFAFGNSSATGSLFGFSFNAPLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKPFAFGNSSATGSLFGFSFNAPLK 25 1 J3KNE0;A6NKT7;P49792 J3KNE0;P49792 RGPD3;RANBP2 RanBP2-like and GRIP domain-containing protein 3;E3 SUMO-protein ligase RanBP2 0 394139900.0 110270000.0 104340000.0 179529900.0 False True 167287651.81683743 85719711.78785913 144045736.57424954 1.0 0.5124090801496413 0.861066163639888 27.31775571720629 -9.889562510010244 6.482791461242398 1.0000000198231906 0.6867376218947461 0.5183883396059208 0.14233865829308157 4.0701242092755136e-08 6.969302205624284e-09 0.1378188214872508 0.04593960442420714 1.2895479339512717e-10 9.889562510010244 -0.31326239792844457 SKPFAFGNSSATGSLFGFSFNAPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKPFAFGNSSATGSLFGFSFNAPLK 25 1 J3KNE0;A6NKT7;P49792 J3KNE0;P49792 RGPD3;RANBP2 RanBP2-like and GRIP domain-containing protein 3;E3 SUMO-protein ligase RanBP2 0 6763400.0 2124200.0 1636900.0 3002300.0 False True 2909574.1443465487 1564576.345495565 2293218.5743094156 1.0 0.5377337946639431 0.7881629614991102 21.472376579915263 -10.074272566152738 5.203592512362062 1.000005135563199 0.6629483780808931 0.7071955090678884 0.10223727924495941 6.091197435632176e-06 1.0837504134642652e-06 0.09899232712806826 0.032996939989455215 8.428056412251605e-11 10.074272566152738 -0.3370567574823058 SKPFAFGNSSATGSLFGFSFNAPLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKPFAFGNSSATGSLFGFSFNAPLK 25 1 J3KNE0;A6NKT7;P49792 J3KNE0;P49792 RGPD3;RANBP2 RanBP2-like and GRIP domain-containing protein 3;E3 SUMO-protein ligase RanBP2 0 66075000.0 26268000.0 14912000.0 24895000.0 False True 21843005.869709663 14831666.096199762 30100429.398525365 1.0 0.679012137096354 1.3780351284099828 24.38066806694037 -6.781827048277779 1.5285426666634312 0.8186820117066868 1.38391445778499 0.7738777287817631 0.13585294286944527 0.24774141227421084 1.1433798437227396 0.06999057830934162 0.16491248038260115 1.652619799993825e-07 6.781827048277779 0.5652324460783033 SKPFAFGNSSATGSLFGFSFNAPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKPFAFGNSSATGSLFGFSFNAPLK 25 1 J3KNE0;A6NKT7;P49792 J3KNE0;P49792 RGPD3;RANBP2 RanBP2-like and GRIP domain-containing protein 3;E3 SUMO-protein ligase RanBP2 0 267268000.0 110270000.0 88989000.0 68009000.0 False True 142746688.74666166 84036683.92238213 55632059.83126847 1.0 0.5887119670532284 0.38972574649350317 27.08888203929874 -12.560918680796583 0.11051029081140885 2.4869626134556366 7.7041534301657615e-22 0.9997892411124524 0.0036891769932334943 7.093490546111307 0.08591321681845622 2.682745508981095 0.30851348728482475 2.7484087290289093e-13 12.560918680796583 -2.4869626134556366 SKPYFELK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKPYFELKAK 10 2 O60239;O60239-2;C9JK30 O60239 SH3BP5 SH3 domain-binding protein 5 1 30981300.0 3458200.0 7090100.0 20433000.0 True False 3348421.3339229748 9921213.904383043 15080984.323139438 1.0 2.9629526618621362 4.503908803337697 21.675049643842108 -7.681821751366343 0.21952513594993625 5.751034086650095e-22 6.400837579524794 0.9998674481094048 0.016508874619197086 0.13606689841814887 0.028542652738163154 0.24429252327101997 0.44952403148681236 2.080550437710905e-08 7.681821751366343 6.400837579524794 SKPYFELK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKPYFELKAK 10 2 O60239;O60239-2;C9JK30 O60239 SH3BP5 SH3 domain-binding protein 5 1 59299100.0 7371100.0 33374000.0 18554000.0 True False 11182497.599592738 27418148.947747808 14886793.767492922 1.0 2.4518806021247315 1.3312583915095222 23.414739112868734 -6.580791714592556 2.2642357789089993 1.9882418387192797 1.3341001773087937 0.0 0.6306203254470248 0.696958235015286 6.722158809321204 0.23377485535262446 0.7046047651217701 2.625477406994946e-07 6.580791714592556 -0.654141661410486 SKPYFELK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKPYFELKAK 10 2 O60239;O60239-2;C9JK30 O60239 SH3BP5 SH3 domain-binding protein 5 1 13802000.0 2551600.0 3087200.0 8163200.0 True False 3494995.4743972607 2950797.2959948136 6235220.28638132 1.0 0.844292165071745 1.784042449284325 21.736859156807903 -6.864336427659999 1.1635600397886015 0.9143256722483769 1.8334826185783293 0.958700727474102 0.08357401476371233 0.14240513207857056 0.3639131209018424 0.055911588640319906 0.1312260965233645 1.3666697202000913e-07 6.864336427659999 0.9191569463299524 SKPYFELK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKPYFELKAK 10 2 O60239;O60239-2;C9JK30 O60239 SH3BP5 SH3 domain-binding protein 5 1 20136800.0 3458200.0 8504400.0 8174200.0 True False 2875646.5242359503 8458585.109208765 9883387.426769475 1.0 2.941455091201163 3.4369270852562304 21.455454919276384 -9.851146007435586 0.3500680305027104 3.5510605202960055e-24 3.544832166233323 0.9987201268681782 0.037622437217595416 1.2029842061941662 0.15260126356443632 1.4365362039502356 0.1459532263628154 1.40881508285077e-10 9.851146007435586 3.544832166233323 SKPYFELK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKPYFELKAK 10 2 O60239;O60239-2;C9JK30 O60239 SH3BP5 SH3 domain-binding protein 5 1 39321400.0 7371100.0 29526000.0 2424300.0 True False 9542034.256103368 27882852.144560058 1983102.275418611 1.0 2.9221077388949173 0.20782803982810688 23.185865434961183 -6.716481843850891 1.7719723272634451 2.1737664066333826 0.21288061669793762 0.49584540901183294 0.809199803156959 0.3622102078995718 2.220684468061028 0.36287326587487356 0.9147394957946144 1.9209592678468947e-07 6.716481843850891 -1.960885789935445 SKSEDMDNVQSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKSEDMDNVQSKR 13 2 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 2380800.0 786480.0 551120.0 1043200.0 True False 761513.6228973856 771185.090052833 769954.6246708297 1.0 1.0127003206044425 1.0110845052795352 19.53851032009318 -10.551440768034334 6.733729072634422 0.9999886554087895 1.0118924129419595 0.9863426689934405 0.0006596538440987157 1.124555347532985e-07 7.491177366035528e-09 0.0006393163904732972 0.00021290236270466852 2.8090484633279048e-11 10.551440768034334 0.011903757533170078 SKSEDMDNVQSK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKSEDMDNVQSKR 13 2 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 4223630.0 1326900.0 435130.0 2461600.0 True False 2013004.309383889 357477.6518137929 1975063.681042393 1.0 0.1775841463167083 0.9811522369005219 20.94091883006833 -9.047556853709153 11.726348564732714 0.9999911002621591 0.5793681915875898 0.2675818675504561 0.3280552992924816 0.0 0.0 0.3176381776804952 0.10587939256016504 8.96278845954887e-10 9.047556853709153 -0.4206229086745693 SKSEDMDNVQSK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKSEDMDNVQSKR 13 2 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 2379960.0 786480.0 941790.0 651690.0 True False 653992.9669715714 936716.3903393215 787955.3659258884 1.0 1.4323034614224526 1.2048376752041436 19.318915595527457 -10.067978398248602 4.241198252222254 0.9999657162623653 1.3185705681716822 0.7233961017932997 0.09286251858586078 64944777.34102196 109305707.45401768 30658.353856911282 0.03398420311129179 8.551092448502243e-11 10.067978398248602 0.31860485190931687 SKSEDMDNVQSK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKSEDMDNVQSKR 13 2 Q6VMQ6-2;Q6VMQ6-5;Q6VMQ6;Q6VMQ6-4 Q6VMQ6-2 ATF7IP Activating transcription factor 7-interacting protein 1 1 4027770.0 1326900.0 789070.0 1911800.0 True False 1717698.2071093244 745157.5608517241 1563872.0167245406 1.0 0.43381168925228897 0.910446323022218 20.71204515216078 -10.164025300470165 7.700261980548624 1.000000119806064 0.6721290061372577 0.3868487269965233 0.19458527441244294 4.0023833847543784e-07 4.3569085247589837e-08 0.18840645058641572 0.06280212726804932 6.854482934809615e-11 10.164025300470165 -0.3278711136688063 SKTEDHEEAGPLPTK(ub)VNLAHSEI ddPTM_RPMI8226_Bortezomib_1h_R1 1 SKTEDHEEAGPLPTKVNLAHSEI 23 2 Q9BXS4;Q5T6Z8 Q9BXS4 TMEM59 Transmembrane protein 59 1 536040000.0 148070000.0 171560000.0 216410000.0 True False 194121203.91191986 145963916.73564216 194017969.15130305 1.0 0.7519215510422629 0.9994681943108922 27.532382471729527 -10.923314990872527 9.54513906960756 1.0230419890418947 0.8756948726765553 0.25161122070808817 0.10106049392448566 0.04681331713498102 0.00037609462131543855 0.0924380902749774 0.0326171341607524 1.1931224268797594e-11 10.923314990872527 -0.14734711636533937 SKTEDHEEAGPLPTK(ub)VNLAHSEI ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKTEDHEEAGPLPTKVNLAHSEI 23 2 Q9BXS4;Q5T6Z8 Q9BXS4 TMEM59 Transmembrane protein 59 1 335614000.0 110190000.0 156770000.0 68654000.0 True False 106692078.76495661 219369078.54474998 50671457.82414796 1.0 2.056095270465407 0.47493177010617194 26.66887782794417 -6.726654717758999 1.7350919120061872 1.6378908022878704 0.4763721829507594 0.5438554409765926 0.444085766616566 0.34253725561808507 2.0186052519162265 0.20294198902215868 0.5055698112075355 1.876485799706485e-07 6.726654717758999 -1.161518619337111 SKTEDHEEAGPLPTK(ub)VNLAHSEI ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKTEDHEEAGPLPTKVNLAHSEI 23 2 Q9BXS4;Q5T6Z8 Q9BXS4 TMEM59 Transmembrane protein 59 1 793030000.0 417200000.0 250570000.0 125260000.0 True False 632922901.4055002 205853825.78765428 100502306.09659179 1.0 0.3252431304516316 0.15879075614646168 29.237454529630373 -13.99999999999998 0.1965730895522292 4.7030477206191685 0.04696425055202312 0.9994871156360884 0.00823716779401464 12.465202915827746 0.14059525738193812 17.722798746869 0.10876157369742517 1.000000000000045e-14 13.99999999999998 -4.656083470067146 SKTEDHEEAGPLPTK(ub)VNLAHSEI ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKTEDHEEAGPLPTKVNLAHSEI 23 2 Q9BXS4;Q5T6Z8 Q9BXS4 TMEM59 Transmembrane protein 59 1 415290000.0 148070000.0 140520000.0 126700000.0 True False 202815480.44129273 134311361.76250026 96776069.46840869 1.0 0.6622342706299396 0.4771631300423423 27.595592533252418 -11.48603510440391 0.09701294799019017 2.1142351287815386 7.082402746890087e-16 0.9998874789364396 0.0022961154586656944 4.370518512737495 0.06487064946341124 1.3744216999285706 0.33083939130210444 3.2656143485827047e-12 11.48603510440391 -2.1142351287815377 SKTEDHEEAGPLPTK(ub)VNLAHSEI ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKTEDHEEAGPLPTKVNLAHSEI 23 2 Q9BXS4;Q5T6Z8 Q9BXS4 TMEM59 Transmembrane protein 59 1 298163000.0 110190000.0 143650000.0 44323000.0 True False 91627867.24468212 142876128.9377076 53590734.37360274 1.0 1.5593086823266622 0.5848737505861027 26.449283103378445 -6.751047613014239 1.6459013495761126 1.3284712576106572 0.5827780828918423 0.6534470441174525 0.2350395713542776 0.29824603185586823 1.5899378217434172 0.11279100747989679 0.2735326773778896 1.7739949818069216e-07 6.751047613014239 -0.7456931747188149 SKTEDHEEAGPLPTK(ub)VNLAHSEI ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKTEDHEEAGPLPTKVNLAHSEI 23 2 Q9BXS4;Q5T6Z8 Q9BXS4 TMEM59 Transmembrane protein 59 1 777900000.0 417200000.0 258680000.0 102020000.0 True False 540073624.2414725 244284230.6020048 83453406.81359835 1.0 0.4523165354447726 0.1545222782001394 29.008580851722822 -8.739681496385334 0.28765611663064994 1.2228278144109304 1.5143171160472044e-15 0.998825951129055 0.011997818262528097 0.2925307347218087 0.08864143499622022 0.16728640803784575 0.10034805889450447 1.8210358833555303e-09 8.739681496385334 -1.2228278144109288 SKTHAVLVALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SKTHAVLVALK 11 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 8271400.0 2038900.0 2437300.0 3795200.0 False True 3093160.3635562686 2002344.772288181 3045077.056504745 1.0 0.6473459300332055 0.9844549582304096 21.5606502005884 -10.642776320573175 9.301004735553061 1.0000876019162284 0.8159004444605369 0.2845144448254284 0.13762418446144278 0.00025011832272264084 9.606178962994678e-06 0.133316983565394 0.04441801453787878 2.2762695008379487e-11 10.642776320573175 -0.18418715745569147 SKTHAVLVALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SKTHAVLVALK 11 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 2135830.0 970170.0 600540.0 565120.0 False True 1328868.066858437 574006.1570797884 431650.29501173686 1.0 0.4319512007213706 0.32482554572343425 20.341766446897317 -13.999999999999963 0.23458088599807184 4.663625482895825 0.2749595482238621 0.9995163805478362 0.006515509284384107 13.438308588334946 0.15332425086662144 22.990719314413763 0.054065924010503155 1.0000000000000858e-14 13.999999999999963 -4.388665934671963 SKTHAVLVALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SKTHAVLVALK 11 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 10652000.0 2038900.0 4976400.0 3636700.0 False True 2639396.242727563 4699458.965392824 2974857.9156931327 1.0 1.7805052872759963 1.1270978822864817 21.33177652268085 -10.097942956282331 4.446366601935571 0.9999593552128903 1.4538015844959846 0.3914075553510097 0.26675245615857013 40544048.14649139 46038889.345976435 14138.935055489348 0.09131646079205143 7.980995091692178e-11 10.097942956282331 0.45384222928309437 SKVDEAVAVLQAHQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SKVDEAVAVLQAHQAK 16 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAS6;H0YB75;H0YAS7;H0YC10 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 12889800.0 3115500.0 2389600.0 7384700.0 False True 3016600.157838478 3343779.7415993805 5450425.533748731 1.0 1.108459711808588 1.806810730148006 21.524492053169794 -6.934360055435689 0.7100914460781836 0.9909024674824888 1.9675132190880056 0.9973279366283527 0.018481055260535926 0.09043614823940282 0.06704701530123074 0.0172974370067653 0.06174408288929575 1.1631613010514366e-07 6.934360055435689 0.9766107516055168 SKWDEEWDK(ub)NK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SKWDEEWDKNK 11 2 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 59187300.0 30648000.0 23811000.0 4728300.0 True False 25485169.936609622 23682725.416886542 5716965.668810911 1.0 0.9292747694362494 0.22432519316257138 24.603154637462147 -6.926249075301086 0.776963204558767 1.0123412001147645 0.09252012286704389 0.9957482989345788 0.02283343883943882 0.09463279442445593 0.08756819523785739 0.020355635425544402 0.06515078700433007 1.1850888845180548e-07 6.926249075301086 -0.9198210772477206 down SLAEDFAEQPIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLAEDFAEQPIK 12 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1;J3QL06 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 9707900.0 2305000.0 1718300.0 5684600.0 False True 2231829.0366932102 2404426.150816123 4195632.725655485 1.0 1.0773343796882584 1.879907760261039 21.08979508692069 -6.925596950863115 0.782083018370909 0.9856007671188753 2.0276058932648997 0.995599985319371 0.026388395491191593 0.09498923490102218 0.08935714990067517 0.02343882069171681 0.07445425443521624 1.1868697175058703e-07 6.925596950863115 1.0420051261460244 SLAFHRPPYHLLQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLAFHRPPYHLLQQR 15 1 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 0 5962400.0 1373200.0 961800.0 3627400.0 False True 1329608.5176516771 1345851.7557207402 2677275.1203326015 1.0 1.0122165568687478 2.0135815052246664 20.342570098673885 -6.9095653390945255 0.8987092518729061 0.9685653142062528 2.1417859372249506 0.9907555191345261 0.04566594642106743 0.10470719577118966 0.1403410038222784 0.037306668212429665 0.10267321968040934 1.2315006939657918e-07 6.9095653390945255 1.1732206230186977 up SLAFHRPPYHLLQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLAFHRPPYHLLQQR 15 1 Q6P2E9;Q6P2E9-2 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 0 9477700.0 1373200.0 4251000.0 3853500.0 False True 1141876.6430746652 4228099.019242568 4659249.033429109 1.0 3.7027633806904134 4.080343583246801 20.12297537410816 -9.969343511607862 0.47208777672540836 6.522933053091502e-26 4.082375662165935 0.9990809148739249 0.04158744149668127 1.2655125079999217 0.21361679796582117 1.9134850651097441 0.08070791102027851 1.0731402604886621e-10 9.969343511607862 4.082375662165935 SLAFQK(ub)LGMESR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLAFQKLGMESR 12 1 Q9UJC3;Q9UJC3-2 Q9UJC3 HOOK1 Protein Hook homolog 1 1 7914000.0 1001300.0 2022200.0 4890500.0 True False 969514.2795839092 2829675.0056336885 3609531.3381448383 1.0 2.918652221242283 3.7230306083722224 19.88690262179743 -9.280155513335412 0.28332070693750866 1.1595876653514367e-24 4.111758158671364 0.9988128749122701 0.039356749630909474 0.6879285098966099 0.10691163191713172 0.9746030178086281 0.29846590596784245 5.246195694260192e-10 9.280155513335412 4.111758158671364 SLAFQK(ub)LGMESR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLAFQKLGMESR 12 1 Q9UJC3;Q9UJC3-2 Q9UJC3 HOOK1 Protein Hook homolog 1 1 5700600.0 1001300.0 2310100.0 2389200.0 True False 832625.3151111726 2297655.03278105 2888770.6735873427 1.0 2.7595305968738963 3.4694725480471758 19.667307897231705 -9.404788550439894 0.27880655926319786 3.840250617262787e-24 3.8155468629924187 0.998860115676261 0.035047419345998115 0.8001196714542882 0.10899345329440059 1.015393222660018 0.2704645032002511 3.9374173400825057e-10 9.404788550439894 3.8155468629924187 SLAGQSGQGK(ub)PR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLAGQSGQGKPR 12 1 P04920-2;P04920-3;P04920 P04920-2 SLC4A2 Anion exchange protein 2 1 5591500.0 156120.0 968480.0 4466900.0 True False 151164.0560557676 1355199.11455648 3296884.8858724376 1.0 8.965088327985315 21.80997898505811 17.20575560926822 -6.964025902336155 0.37439432356025604 0.06013924177847971 31.165143772437236 0.9998916355814691 0.08924490555399632 0.07829309845430174 0.016035097639573125 0.16825896262548948 1.0883987066213001 1.0863608285904123e-07 6.964025902336155 31.105004530658757 SLAGQSGQGK(ub)PR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLAGQSGQGKPR 12 1 P04920-2;P04920-3;P04920 P04920-2 SLC4A2 Anion exchange protein 2 1 3924620.0 156120.0 1215000.0 2553500.0 True False 129820.69728868116 1208454.5538413816 3087425.04394997 1.0 9.308643221613204 23.782225087610566 16.986160884702496 -6.962653224796603 0.39627075645955784 0.17089356611318546 33.44529080670526 0.9998563008076707 0.11284551355797157 0.07876659966454926 0.017726453645504597 0.18637489438144703 1.2143793914491636 1.0897999288228545e-07 6.962653224796603 33.27439724059207 SLAGSSGPGASSGTSGDHGELVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLAGSSGPGASSGTSGDHGELVVR 24 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7 E9PI39;P29692 EEF1D Elongation factor 1-delta 0 87455600.0 11381600.0 49897000.0 26177000.0 False True 14921387.819571171 42452562.096982665 23468455.147514764 1.0 2.845081342990167 1.57280645951264 23.83087838930194 -10.478424284982781 5.03722190414004 0.9971482363304802 2.20894390125145 0.5462581696924625 0.5194040461799732 0.016655400202952374 0.0017245708577570248 0.5035404621367165 0.16763693506729202 3.323347194855041e-11 10.478424284982781 1.2117956649209698 SLAGSSGPGASSGTSGDHGELVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLAGSSGPGASSGTSGDHGELVVR 24 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7 E9PI39;P29692 EEF1D Elongation factor 1-delta 0 75913000.0 19967000.0 10692000.0 45254000.0 False True 19333158.514383215 14961371.358043399 33400619.809100553 1.0 0.7738710333809473 1.727633887874639 24.204574018304417 -6.844186219929474 1.262936669365936 0.8796948910316688 1.7616690622271969 0.9313934809351084 0.10658371455880049 0.16396914175037972 0.5062295060285034 0.06612776240820241 0.15254976546919793 1.431573927027319e-07 6.844186219929474 0.8819741711955281 SLAGSSGPGASSGTSGDHGELVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLAGSSGPGASSGTSGDHGELVVR 24 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7 E9PI39;P29692 EEF1D Elongation factor 1-delta 0 274193000.0 16652000.0 241640000.0 15901000.0 False True 25262301.424267482 198517454.0580629 12758160.38034413 1.0 7.858248966476308 0.505027636480039 24.5904827404761 -6.66183713500268 1.9663912414070575 5.407847985236962 0.5355773175761354 0.2434698477110232 2.918802344792614 0.4800801365241492 3.5704248900747446 1.198434928959774 3.2362952569169905 2.1785265895643555e-07 6.66183713500268 -4.8722706676608265 SLAGSSGPGASSGTSGDHGELVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLAGSSGPGASSGTSGDHGELVVR 24 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7 E9PI39;P29692 EEF1D Elongation factor 1-delta 0 79868600.0 11381600.0 31769000.0 36718000.0 False True 15589685.096174875 30365340.53396576 28045964.630947333 1.0 1.9477840858643307 1.79900777071044 23.89408845082483 -10.164930079056525 5.1041172076777075 0.9999522569954373 1.8733959282882955 0.9787011269035799 0.060737676326266456 3.300053096717464e-05 5.399187478549795e-06 0.058812197746647234 0.019603000741124466 6.840217651836703e-11 10.164930079056525 0.8734436712928582 SLAGSSGPGASSGTSGDHGELVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLAGSSGPGASSGTSGDHGELVVR 24 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7 E9PI39;P29692 EEF1D Elongation factor 1-delta 0 32189200.0 19967000.0 7213700.0 5008500.0 False True 16603445.18808028 7174838.366292663 6055754.19331248 1.0 0.4321294939103076 0.3647287731379958 23.984979293738693 -13.999999999999998 0.30069745537474646 6.200755116069926 0.34826430091055544 0.9996513864967405 0.005319701282391438 16.63398236040173 0.17417051877336098 53.84515933419143 0.024285307465727265 1.0000000000000041e-14 13.999999999999998 -5.852490815159371 SLAGSSGPGASSGTSGDHGELVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLAGSSGPGASSGTSGDHGELVVR 24 0 E9PI39;E9PQ49;E9PPR1;E9PL12;E9PMW7;H0YCK7;E9PIZ1;P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7 E9PI39;P29692 EEF1D Elongation factor 1-delta 0 50640000.0 16652000.0 17651000.0 16337000.0 False True 21556342.25999282 16668706.333523972 13363833.63177571 1.0 0.7732622785666201 0.6199490372992511 24.36160906256855 -8.00615842512969 0.08714131076558479 1.5483448710944705 2.0276234957415228e-11 0.9999942969510152 0.00037278006254732216 0.1078959483068748 0.0143161515681961 0.11593807222008262 0.1292385927458187 9.859197689732271e-09 8.00615842512969 -1.5483448710741943 SLAIHLWYLLPPTASISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLAIHLWYLLPPTASISR 18 0 P52948-6;P52948-2;P52948-5;P52948;H7C3P6;H0YDF4 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 0 45305000.0 16061000.0 11180000.0 18064000.0 False True 24365711.21638005 9184841.650261315 14493642.48226754 1.0 0.3769576668087049 0.5948376533546073 24.53834899851559 -10.272189424596199 6.698379815404391 1.0000068532610882 0.4858976600816751 0.8812831775564447 0.08894913203365425 9.103700676940133e-06 9.891207969631555e-07 0.08612577375391516 0.028708208918828967 5.343312513048093e-11 10.272189424596199 -0.5141091931794131 SLAIHLWYLLPPTASISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLAIHLWYLLPPTASISR 18 0 P52948-6;P52948-2;P52948-5;P52948;H7C3P6;H0YDF4 P52948-6 NUP98 Nuclear pore complex protein Nup98-Nup96;Nuclear pore complex protein Nup98;Nuclear pore complex protein Nup96 0 38262000.0 16061000.0 10595000.0 11606000.0 False True 20791281.109641194 10005378.936246494 9493827.08761639 1.0 0.4812295540368057 0.45662540165521476 24.30947532060804 SLAPSIHGHDYVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLAPSIHGHDYVK 13 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 7031100.0 1226400.0 3368300.0 2436400.0 False True 1607822.2764744947 2865762.7695305627 2184304.6995990714 1.0 1.782387774732404 1.358548598038237 20.616676513764375 -10.19497162216401 4.521189867448742 0.9998692211523248 1.5704681863934535 0.7072134555629006 0.17303161934476174 0.00022815172573904474 4.0623998587589104e-05 0.16757523496189766 0.055845715062438 6.383051932097612e-11 10.19497162216401 0.5705989652411287 SLAPSIHGHDYVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLAPSIHGHDYVK 13 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 5738960.0 1424300.0 733360.0 3581300.0 False True 1379086.3761224046 1026194.472421878 2643250.0933029563 1.0 0.7441118193823671 1.9166675409665184 20.39528138912087 -6.849529332294373 1.2373250403580998 0.863500660155208 1.9631273417064816 0.9396243062647414 0.12369115996970957 0.1579735350825844 0.46563882808887436 0.07823262439672682 0.18098521857024757 1.4140692154632807e-07 6.849529332294373 1.0996266815512736 SLAPSIHGHDYVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLAPSIHGHDYVK 13 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 5971700.0 1226400.0 2087500.0 2657800.0 False True 1679833.2222138268 1995267.3475606248 2030082.3791092075 1.0 1.187777049040078 1.2085023395559427 20.679886575287266 -13.078485527672518 0.3236099565151176 2.1337666836383894e-06 1.2125689381274114 0.9996551536842961 0.0017416072804457105 10.1752768249225 0.17920557734385606 6.757803705866561 0.00680637477172721 8.346693621400021e-14 13.078485527672518 1.2125668043607278 SLASVLTTNK(ub)TLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLASVLTTNKTLER 14 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 58440900.0 15593500.0 16787600.0 26059800.0 True False 20443229.507668816 14282955.517552285 23363381.879252937 1.0 0.6986643432337516 1.142842028481297 24.285119787427487 -6.724003989443065 1.7448103725266375 0.8174580349652468 1.142314462780434 0.5313486970113467 0.1267452914356839 0.3476141792035176 2.0702317462273014 0.05762990767506092 0.14400110025324986 1.8879740060267552e-07 6.724003989443065 0.3248564278151872 SLASVLTTNK(ub)TLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLASVLTTNKTLER 14 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 67300400.0 17690900.0 20572000.0 29037500.0 True False 17129312.063009076 28786506.88156274 21431707.643672567 1.0 1.6805407465094582 1.2511715336166103 24.029963876157982 -10.122128093999326 4.229927270426943 0.9999170961695577 1.465856140058038 0.6108297678162032 0.17528924739190618 81522527.16973749 78323221.60883452 84279.93406151654 0.06414929521011273 7.548695480674424e-11 10.122128093999326 0.4659390438884804 SLASVLTTNK(ub)TLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLASVLTTNKTLER 14 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 219123000.0 36712000.0 69552000.0 112859000.0 True False 55694788.00670842 57139902.187743686 90552369.182143 1.0 1.0259470272310076 1.6258679209127431 25.731038988748157 -6.915972114884589 0.8540644747847028 0.9847457720434816 1.71418315119476 0.9929868896281726 0.024211763347711714 0.10060041390523504 0.11832329887062856 0.020427518834773888 0.05902029213931819 1.2134667620568093e-07 6.915972114884589 0.7294373791512785 SLASVLTTNK(ub)TLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLASVLTTNKTLER 14 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 74685800.0 15593500.0 33833000.0 25259300.0 True False 21358838.34849259 32338146.189230517 19293573.571613073 1.0 1.5140404951617041 0.9033063154848366 24.348329848950378 -6.683526700430094 1.8892669472964099 1.324205922884404 0.9055597038923708 0.34033587360829376 0.21769702807984403 0.4307605283655084 2.9755833535168312 0.09235640109049979 0.242496829344175 2.0723986445716947e-07 6.683526700430094 -0.41864621899203325 SLASVLTTNK(ub)TLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLASVLTTNKTLER 14 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 68517800.0 17690900.0 26842700.0 23984200.0 True False 14710767.189753573 26698093.04724124 28999185.329588782 1.0 1.81486748467049 1.971289801240785 23.81036915159226 -10.984646312660654 0.310918050546111 1.505818194436693e-13 2.0127699208702743 0.9992611567036079 0.0115744158332066 2.842159571370812 0.15805997437714422 2.0939557730070484 0.05378634081774249 1.0359855248530026e-11 10.984646312660654 2.0127699208701237 SLASVLTTNK(ub)TLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLASVLTTNKTLER 14 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 169731000.0 36712000.0 56170000.0 76849000.0 True False 47524407.70170893 53044090.12260177 62863270.537328236 1.0 1.1161441601868582 1.3227575803131522 25.502165310840606 -6.962269301815307 0.4021775429823338 0.9889114184084894 1.4575611559465473 0.9998453189621784 0.0016600857847346015 0.07890026391605258 0.01820781726362147 0.002658022917264036 0.01729697378725993 1.090763754626106e-07 6.962269301815307 0.46864973753805794 SLASYGLK(ub)DGDVVILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLASYGLKDGDVVILR 16 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 45917700.0 13919300.0 22025900.0 9972500.0 True False 18248337.094692953 18739721.576285742 8940641.362974774 1.0 1.026927630668095 0.48994279953185016 24.121261666585248 -6.895098762440513 0.9917537676708146 1.0254261107226386 0.4388702626499156 0.9839654384028138 0.031281447547732065 0.11510277366003728 0.19847217351479146 0.023857783633629663 0.060678711011430624 1.273213507979216e-07 6.895098762440513 -0.586555848072723 down SLASYGLK(ub)DGDVVILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLASYGLKDGDVVILR 16 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 92736800.0 33672300.0 30415100.0 28649400.0 True False 32603391.26778517 42560008.04265112 21145262.676423006 1.0 1.30538592421531 0.648560221933608 24.95851869954995 -6.780264329152966 1.534693158968986 1.1728573293851547 0.643300496151685 0.768370266661667 0.12915975835876872 0.25016548032880853 1.163799033763243 0.06628301760129313 0.15637521851030492 1.6585771231816147e-07 6.780264329152966 -0.5295568332334697 SLASYGLK(ub)DGDVVILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLASYGLKDGDVVILR 16 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 113102000.0 45290900.0 5512300.0 62298800.0 True False 68709606.50830868 4528586.997203523 49985414.873466 1.0 0.06590908065607835 0.7274880095175852 26.034008485132617 -10.450596061553062 8.120342627340742 1.00002085384546 0.39669854554740197 0.5257914574265247 0.2700884667146238 0.00010197257376949693 6.89930687534933e-06 0.2615210342477353 0.08717067779903614 3.543267481146256e-11 10.450596061553062 -0.6033223082980581 SLASYGLK(ub)DGDVVILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLASYGLKDGDVVILR 16 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 43034900.0 13919300.0 19887400.0 9228200.0 True False 19065641.364938784 19008708.90916274 7048689.220744813 1.0 0.9970138714619514 0.3697063783916112 24.18447172810814 -6.90794291427764 0.9096101408635906 1.0207091546658995 0.2921007548361722 0.9901222104703795 0.029460506540859705 0.10579491151810015 0.14625533616809064 0.023876968235389224 0.06501016779888319 1.2361099029029526e-07 6.90794291427764 -0.7286083998297272 down SLASYGLK(ub)DGDVVILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLASYGLKDGDVVILR 16 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 78850900.0 33672300.0 31676300.0 13502300.0 True False 28000009.3858164 31505653.484646723 16325568.502418503 1.0 1.1252015329897043 0.5830558224987001 24.738923974984225 -6.84593529956615 1.2546499298964109 1.0666445204471422 0.5630361662259561 0.9341636510694606 0.05946793148147939 0.16198618103928383 0.4927543076672574 0.03712581915725868 0.08571224325575419 1.425819993954198e-07 6.84593529956615 -0.5036083542211861 SLASYGLK(ub)DGDVVILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLASYGLKDGDVVILR 16 1 Q5TDH0;Q5TDH0-3;Q5TDH0-2 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 82412900.0 45290900.0 6021600.0 31100400.0 True False 58629962.8671096 5686492.666588181 25440446.317051936 1.0 0.09698953211819626 0.43391544311080554 25.805134807225066 -10.535572216320755 6.260857860753673 1.000908455275916 0.26545248856307935 0.8637115562183091 0.13754942717571245 0.001746063221702728 0.00012952198266840586 0.13332339149410571 0.044393886727658656 2.913585611166239e-11 10.535572216320755 -0.7354559667128366 SLATTRPTVNADDLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLATTRPTVNADDLLK 16 1 Q9UN37 Q9UN37 VPS4A Vacuolar protein sorting-associated protein 4A 0 6230200.0 1621900.0 1617400.0 2990900.0 False True 1570413.672283176 2263236.2546295733 2207493.5649233 1.0 1.441172026564901 1.4056764812254168 20.582713207639056 -10.220738043761568 4.975943386788971 0.9999438706030991 1.4234242538955726 0.9947570633777135 0.014490995705466955 9.024957737780229e-06 1.4133331277706828e-06 0.014032700302388014 0.004676948752882903 6.015364607540433e-11 10.220738043761568 0.4234803832924735 SLAYIHSFGICHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLAYIHSFGICHR 13 0 A0A3B3ITW1;P49841;P49841-2 A0A3B3ITW1 GSK3B Glycogen synthase kinase-3 beta 0 8556910.0 2996800.0 3455280.0 2104830.0 False True 3928833.8210524865 2939765.692575948 1887042.3825550468 1.0 0.7482540179794167 0.48030598098688004 21.905669716348644 -6.9703336709420665 0.250088898624426 1.0849412133878322 0.13577006782259157 0.9999848685677113 0.0008254139987806531 0.07619458677206305 0.008641919424526242 0.005972637820227491 0.025676541161445757 1.0706963669824793e-07 6.9703336709420665 -0.9491711455652406 down SLAYIHSFGICHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLAYIHSFGICHR 13 0 A0A3B3ITW1;P49841;P49841-2 A0A3B3ITW1 GSK3B Glycogen synthase kinase-3 beta 0 9108200.0 2996800.0 1863500.0 4247900.0 False True 4104797.945474886 1781164.4082295704 3244633.5082466737 1.0 0.4339225540183091 0.7904490187692541 21.968879777871535 -10.448108942032789 6.830885152712814 1.00006587479677 0.6121857863937995 0.6120453464797488 0.145551319739698 0.0001460452280262988 1.1799432861341936e-05 0.14095324569184864 0.0469764864475301 3.563617294790244e-11 10.448108942032789 -0.3878800884029704 SLCAK(ub)HGIEYQEK(ub)PLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLCAKHGIEYQEKPLLR 17 2 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 2 49565900.0 5109900.0 10829000.0 33627000.0 True False 6699128.384341984 9213355.411111385 30147600.612960912 1.0 1.3753065895327454 4.50022732560635 22.675541969762023 -6.929359685808926 0.7520311550750424 0.9513333510123233 5.131417048730293 0.9964108717924182 0.09400140698729517 0.09297167185112229 0.07931944013177392 0.08531587118399288 0.283753548313127 1.1766310755606853e-07 6.929359685808926 4.180083697717969 up SLCAK(ub)HGIEYQEK(ub)PLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLCAKHGIEYQEKPLLR 17 2 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 2 37481700.0 8287900.0 7771800.0 21422000.0 True False 8024805.1510671 10875120.2694016 15810935.55377542 1.0 1.3551880780501542 1.9702578761894247 22.936034932150772 -6.962761128696898 0.3945955644440619 0.9641060501578034 2.383603626538361 0.9998592974019146 0.004754381998537568 0.07872914070500292 0.0175919010074195 0.00792446718424757 0.05164056549772474 1.0895291930423361e-07 6.962761128696898 1.4194975763805577 SLCAK(ub)HGIEYQEK(ub)PLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLCAKHGIEYQEKPLLR 17 2 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 2 49346300.0 5109900.0 8424400.0 35812000.0 True False 6999168.119855204 8052182.152234611 27353943.17129167 1.0 1.1504484553517471 3.908170614404039 22.738752031284914 -6.918163637726852 0.8382377941241852 0.9350308363520219 4.334615670895969 0.9936552414355297 0.106487463460212 0.09926469259349294 0.11130379453625834 0.0908682467712421 0.2675919327121042 1.207358828911115e-07 6.918163637726852 3.3995848345439477 up SLCAK(ub)HGIEYQEK(ub)PLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLCAKHGIEYQEKPLLR 17 2 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 2 45870000.0 8287900.0 7399100.0 30183000.0 True False 6891756.066223802 7359239.579693634 36494125.74957589 1.0 1.067832278011253 5.295330449728484 22.71644020758505 -6.910385021551906 0.8930872117108216 0.8706960422151939 5.846226868907834 0.9910665362444449 0.18988851745205468 0.1041645549437169 0.13738231109851043 0.15576069854576063 0.4311376790270036 1.2291785656546442e-07 6.910385021551906 4.975530826692641 up SLCAK(ub)HGIEYQEKPLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLCAKHGIEYQEKPLLR 17 2 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 86695000.0 13914000.0 17836000.0 54945000.0 True False 18241388.74336768 15174938.324183477 49259818.46965651 1.0 0.8318959996782525 2.700442338172674 24.12071223236012 -6.884941660834456 1.0518874471513575 0.8870911693145492 2.8460637450875526 0.9774564618470211 0.12672444929540796 0.12334137603827501 0.24661473051453048 0.09235342724757734 0.22641262416257016 1.3033418457674827e-07 6.884941660834456 1.9589725757730032 up SLCAK(ub)HGIEYQEKPLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLCAKHGIEYQEKPLLR 17 2 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 58394900.0 8612900.0 12737000.0 37045000.0 True False 8339488.203963103 17822950.522577547 27341803.173821747 1.0 2.1371755780058184 3.2785948615921465 22.991527417231435 -6.971079042777495 0.23096424245022715 0.5413531047647067 4.9070689653621615 0.9999896191380845 0.0029971442168175715 0.07595408526228821 0.007765849688470717 0.029121031404265973 0.11315442593075374 1.068860326030703e-07 6.971079042777495 4.365715860597454 SLCAK(ub)HGIEYQEKPLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLCAKHGIEYQEKPLLR 17 2 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 411688000.0 18978000.0 174340000.0 218370000.0 True False 28791013.47764524 143227664.87536287 175209073.7850291 1.0 4.974735084840687 6.085547280962167 24.779115238574434 -9.31971384232996 0.41883939417230964 2.3591242768800634e-20 6.212415106812734 0.9979780385064674 0.09816792326075857 0.6904140749037477 0.1676883599650708 1.400483354468906 0.2664037877042845 4.789455667541499e-10 9.31971384232996 6.212415106812734 SLCAK(ub)HGIEYQEKPLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLCAKHGIEYQEKPLLR 17 2 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 88237000.0 13914000.0 10300000.0 64023000.0 True False 19058381.811711665 9844911.942454822 48902085.99507446 1.0 0.516565993887528 2.565909660022835 24.18392229388301 -6.844504526985046 1.261211662520745 0.7427607672046348 2.639593907888072 0.9319345125057041 0.22819852598136534 0.16360747427160044 0.503551604707483 0.14175574307387898 0.3271011015254989 1.430525069280502e-07 6.844504526985046 1.8968331406834371 up SLCAK(ub)HGIEYQEKPLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLCAKHGIEYQEKPLLR 17 2 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 87645600.0 8612900.0 8174700.0 70858000.0 True False 7162007.966165007 8130661.268549098 85674080.18962489 1.0 1.1352488445922198 11.962298924319715 22.77193269266571 -6.909624470253275 0.8982754851823744 0.6607779805955265 13.3503926135032 0.990779382514958 0.4931886834458365 0.1046672108290108 0.14011326973402108 0.40303190485125845 1.1096951047085624 1.2313330309884709e-07 6.909624470253275 12.689614632907674 up SLCAK(ub)HGIEYQEKPLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLCAKHGIEYQEKPLLR 17 2 O95864;O95864-4;O95864-2 O95864 FADS2 Fatty acid desaturase 2 1 314798000.0 18978000.0 117540000.0 178280000.0 True False 24567395.11230747 110998795.67403603 145834869.30727616 1.0 4.518134509849976 5.936114457418304 24.550241560666883 -9.008371194657235 0.3563526904622994 1.8348003359768414e-20 6.325365633489915 0.9980098848391418 0.09257024834558053 0.4684021907659267 0.12751077725628224 1.0775075869911162 0.40040559230488326 9.809091943950323e-10 9.008371194657235 6.325365633489915 SLCIPFK(ub)PLCELQPGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLCIPFKPLCELQPGAK 17 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 16330200.0 3268000.0 4624300.0 8437900.0 True False 4957794.922802434 3799057.535179188 6770145.366537044 1.0 0.7662796856937639 1.3655557504807325 22.241267165481567 -6.800940960425655 1.4520471969209565 0.8711946345399447 1.3740222501674086 0.8348785762863384 0.10021392929279971 0.21943428880109675 0.9133101920386949 0.054291075837616276 0.1261905093417994 1.5814630145024936e-07 6.800940960425655 0.5028276156274639 SLDDALK(ub)LTEQPELANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLDDALKLTEQPELANK 17 1 P00374;P00374-2;B4DM58 P00374 DHFR Dihydrofolate reductase 1 57937000.0 11964000.0 18279000.0 27694000.0 True False 15684919.859540826 15551844.450983953 24828490.53960626 1.0 0.9915157100100881 1.5829529740634014 23.902874822112313 -6.903649251730147 0.9379362567517241 0.9778107618524917 1.6498416614958846 0.9882951236851082 0.02994977637956147 0.10876840772474983 0.16266965025773827 0.023774944940864247 0.06306951428912118 1.248391342688741e-07 6.903649251730147 0.6720308996433929 SLDDALK(ub)LTEQPELANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLDDALKLTEQPELANK 17 1 P00374;P00374-2;B4DM58 P00374 DHFR Dihydrofolate reductase 1 116431000.0 18421000.0 29564000.0 68446000.0 True False 17836235.438145623 41369059.374223255 50517939.26401415 1.0 2.319382894315745 2.8323207236866534 24.088307812663103 -9.723892883847173 0.25401176083819266 3.6822225963010695e-22 3.123550834290046 0.9990624091320037 0.023633034347326044 1.1352148403929574 0.10780695558731766 1.0880907868666672 0.22273403618975554 1.8884570683727706e-10 9.723892883847173 3.123550834290046 SLDDALK(ub)LTEQPELANK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLDDALKLTEQPELANK 17 1 P00374;P00374-2;B4DM58 P00374 DHFR Dihydrofolate reductase 1 554287900.0 37381000.0 91759000.0 425147900.0 True False 56709709.91715973 75383889.53366072 341117231.21605575 1.0 1.3292942186405083 6.015146819025387 25.757092440825108 -6.9210809845742745 0.8166622877889466 0.9005840167072804 6.789914483937825 0.9944761215001341 0.17023607367269758 0.0975399177514904 0.10234667284162983 0.14752171454059093 0.4465741574019354 1.1992756487215776e-07 6.9210809845742745 5.889330467230545 up SLDDALK(ub)LTEQPELANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLDDALKLTEQPELANK 17 1 P00374;P00374-2;B4DM58 P00374 DHFR Dihydrofolate reductase 1 50861000.0 11964000.0 14725000.0 24172000.0 True False 16387414.114943117 14074400.810936656 18463071.437966645 1.0 0.8588542836726568 1.1266616751407295 23.966084883635205 -6.763502907868703 1.599278194735364 0.9183730209354244 1.127813557371719 0.7051142154599386 0.05939986676467554 0.27706733629125135 1.3974172655220436 0.029294505280922353 0.07015818968479945 1.7238405488154642e-07 6.763502907868703 0.20944053643629457 SLDDALK(ub)LTEQPELANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLDDALKLTEQPELANK 17 1 P00374;P00374-2;B4DM58 P00374 DHFR Dihydrofolate reductase 1 68282000.0 18421000.0 19630000.0 30231000.0 True False 15317877.688667662 19524249.29375009 36552162.32764897 1.0 1.2746053787982878 2.3862419501293357 23.86871308809738 -6.944599801909457 0.6152825658864667 0.9877839311173446 2.7314813063454135 0.9987064384480733 0.02155571426949498 0.08572939050773636 0.04551426481003269 0.021802673971143282 0.09391367783141542 1.1360571990095744e-07 6.944599801909457 1.743697375228069 up SLDDALK(ub)LTEQPELANK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLDDALKLTEQPELANK 17 1 P00374;P00374-2;B4DM58 P00374 DHFR Dihydrofolate reductase 1 556427000.0 37381000.0 58736000.0 460310000.0 True False 48390441.38967046 55467289.966906406 376538303.17944986 1.0 1.1462447618580016 7.781253742806872 25.528218762917557 -6.911655492923433 0.8843920702878499 0.8051670789197864 8.669769187585581 0.9915313118061553 0.2910588204907868 0.1033332634443561 0.13290681596459977 0.24026174727715335 0.6710849704058164 1.2255880198653948e-07 6.911655492923433 7.864602108665795 up SLDFLIELLHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLDFLIELLHK 11 0 E7EX90;Q14203-5;Q14203-2;Q14203-3;Q14203-4;Q14203-6;Q14203;Q6AWB1 E7EX90 DCTN1;DKFZp686E0752 Dynactin subunit 1 0 10736800.0 0.0 5875900.0 4860900.0 False True 0.0 5548900.999668777 3976266.077045875 0.0 SLDIYSFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLDIYSFIK 9 0 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 0 6807900.0 1601600.0 2551500.0 2654800.0 False True 2099713.109916465 2170826.145669101 2380106.762639801 1.0 1.0338679772092603 1.1335390303556714 21.001760790941592 -6.951881795603046 0.5377895588669077 0.9985108676567634 1.1734815433956882 0.999340785952827 0.0014552676661035782 0.08273881350494748 0.032902567938503186 0.0016055328994793556 0.008251323463266192 1.1171672721692666e-07 6.951881795603046 0.17497067573892477 SLDIYSFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLDIYSFIK 9 0 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 0 5616700.0 2242300.0 1214700.0 2159700.0 False True 2171119.413872967 1699736.0445768174 1594009.7803887944 1.0 0.7828846417732183 0.7341879816482818 21.050007647218514 -13.999999999732298 0.21004373248036354 2.2558810185779032 0.7055178321824559 0.9994900340233471 0.0026093956879361772 12.747703538710839 0.14526315105039175 6.607120799501935 0.028836650557574707 1.0000000006164074e-14 13.999999999732298 -1.5503631863954475 SLDIYSFIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLDIYSFIK 9 0 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 0 7328200.0 0.0 4401400.0 2926800.0 False True 0.0 3615935.781704838 2348316.697137991 0.0 SLDIYSFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLDIYSFIK 9 0 Q9NR50;Q9NR50-3;Q9NR50-2;H0Y580 Q9NR50 EIF2B3 Translation initiation factor eIF-2B subunit gamma 0 8002300.0 1601600.0 3550000.0 2850700.0 False True 2193754.8016125793 3393149.2617198685 2177423.3720094142 1.0 1.546731320759112 0.9925554899794817 21.064970852464484 -10.696112025140962 2.8459327093798166 0.9632046564490325 1.2696434052209589 0.2399267138417568 0.2262413382835861 80216412.09646195 81671789.22585377 21445627.737593796 0.08015242131693621 2.0132048818760042e-11 10.696112025140962 0.30643874877192634 SLDLFNCEVTNLNDYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLDLFNCEVTNLNDYR 16 0 H0YN26;P39687;Q92688-2;Q92688 H0YN26;Q92688-2 ANP32A;ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member B 0 21193700.0 4006600.0 12435000.0 4752100.0 False True 5252691.399969599 10579746.471250366 4260398.277361994 1.0 2.0141572511401677 0.811088631132347 22.324625396761476 -6.683225373903862 1.8906168345680747 1.6398043351178484 0.8155653866828865 0.33889385324390064 0.4295241150120679 0.4313792651544697 2.9839402515303792 0.18212175665035793 0.47832506625878973 2.0738370357975166e-07 6.683225373903862 -0.8242389484349619 SLDLFNCEVTNLNDYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLDLFNCEVTNLNDYR 16 0 H0YN26;P39687;Q92688-2;Q92688 H0YN26;Q92688-2 ANP32A;ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member B 0 45672500.0 25267000.0 10825000.0 9580500.0 False True 24464912.915456545 15147478.951629233 7071079.641160741 1.0 0.6191511494021831 0.28902942207872506 24.544210811619212 -7.641011694848707 0.27136088364119926 1.1218952372571875 1.888701387515944e-13 0.9997192771304594 0.004867239982718989 0.12809592649478985 0.033912239858479166 0.03373167689150251 0.07506369602351116 2.2855372567211813e-08 7.641011694848707 -1.1218952372569986 down SLDLFNCEVTNLNDYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLDLFNCEVTNLNDYR 16 0 H0YN26;P39687;Q92688-2;Q92688 H0YN26;Q92688-2 ANP32A;ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member B 0 197930000.0 17426000.0 158180000.0 22324000.0 False True 26436516.01124702 129951543.1340192 17911651.615043223 1.0 4.915607755527742 0.6775344983969513 24.656028725153792 -6.663935179505368 1.9589594688021026 3.5122904728037505 0.6951170360865526 0.25235891571997604 1.6656377995194454 0.4752486922255505 3.5099619820301275 0.6859715646854784 1.847303148380719 2.1680276690017864e-07 6.663935179505368 -2.817173436717198 SLDLFNCEVTNLNDYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLDLFNCEVTNLNDYR 16 0 H0YN26;P39687;Q92688-2;Q92688 H0YN26;Q92688-2 ANP32A;ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member B 0 38280600.0 4006600.0 11052000.0 23222000.0 False True 5487948.294293807 10563686.095923383 17737441.872102503 1.0 1.9248880509510569 3.2320716087185675 22.387835458284368 -6.9662273030896165 0.3363239347408128 0.8520415776044297 4.348118642909054 0.9999362543419376 0.007310897111804925 0.07754691795210217 0.013404863882676702 0.01866767112930082 0.1134528192270144 1.0808680934011597e-07 6.9662273030896165 3.4960770653046245 SLDLFNCEVTNLNDYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLDLFNCEVTNLNDYR 16 0 H0YN26;P39687;Q92688-2;Q92688 H0YN26;Q92688-2 ANP32A;ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member B 0 40419400.0 25267000.0 2532400.0 12620000.0 False True 21010630.017890748 2518757.4585579573 15258783.6517128 1.0 0.11988014906802946 0.7262411283583502 24.32461608705349 -10.287480570959751 7.402133288220877 1.000003068784457 0.423060638865277 0.5469129650765631 0.2475458331992673 1.2536735129267118e-05 1.206765210933067e-06 0.23968649674935388 0.07989507411698343 5.1584524193421186e-11 10.287480570959751 -0.57694242991918 SLDLFNCEVTNLNDYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLDLFNCEVTNLNDYR 16 0 H0YN26;P39687;Q92688-2;Q92688 H0YN26;Q92688-2 ANP32A;ANP32B Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member B 0 50396000.0 17426000.0 14971000.0 17999000.0 False True 22558300.517813783 14137850.689433333 14723366.685335794 1.0 0.6267249910191146 0.6526806695260169 24.42715504724624 -10.715769409861588 6.778075615148926 1.0042670174289967 0.6397028302725724 0.9961228076457693 0.010596361378272488 0.000688304645179296 2.886319188153802e-05 0.010335551295971773 0.003419960929037073 1.9241130721504027e-11 10.715769409861588 -0.36456418715642436 SLDLLGLEK(ub)LDCGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLDLLGLEKLDCGR 14 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 28765400.0 6540000.0 13489000.0 8736400.0 True False 8574003.333450101 11476493.77971018 7832441.133466323 1.0 1.3385221970857506 0.9135103905207627 23.031537547378406 -6.694521819434945 1.850038791123069 1.211331313667137 0.9148846580164083 0.3916561418039609 0.1430436809704031 0.4071058502371051 2.7048114597344535 0.06177024959444896 0.15996154785055755 2.0205899127707948e-07 6.694521819434945 -0.2964466556507288 SLDLLGLEK(ub)LDCGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLDLLGLEKLDCGR 14 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 19554700.0 12105000.0 3753100.0 3696600.0 True False 11720733.400942 5251732.402157949 2728349.564377098 1.0 0.4480719953698346 0.2327797648019039 23.48255951049029 -11.943492359553408 0.1606127059095826 2.4167767016471973 1.3603387378111372e-21 0.9995524621497598 0.00683542430750109 5.2321073343478 0.10629981086849319 2.6771271429949652 0.18606005070731094 1.1389578191319993e-12 11.943492359553408 -2.4167767016471973 SLDLLGLEK(ub)LDCGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLDLLGLEKLDCGR 14 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 113318000.0 29208000.0 49026000.0 35084000.0 True False 44310671.39082423 40276927.2581137 28149632.022136517 1.0 0.9089667566277086 0.6352788422873161 25.40115085077077 -6.951402157913267 0.5432308728964929 1.0039459641280508 0.5275905144073803 0.9993067820767064 0.00408088874816308 0.08292752342645213 0.033669475859911376 0.004468860755048278 0.022677264419745793 1.1184017606349592e-07 6.951402157913267 -0.47635544972067057 SLDLLGLEK(ub)LDCGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLDLLGLEKLDCGR 14 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 40952000.0 6540000.0 11764000.0 22648000.0 True False 8958014.736854563 11244227.581654226 17299008.850201398 1.0 1.2552142312731251 1.9311208295997533 23.094747608901297 -6.954214648976418 0.5104841055175655 0.9876098539376581 2.22840261327704 0.9994918607051837 0.008855569202803502 0.08183624949139025 0.029290533130915838 0.01019137904292326 0.055785984859555236 1.1111823923825541e-07 6.954214648976418 1.2407927593393817 SLDLLGLEK(ub)LDCGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLDLLGLEKLDCGR 14 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 23750000.0 12105000.0 2393400.0 9251600.0 True False 10065843.842425594 2380506.279147294 11186066.785434727 1.0 0.2364934640763965 1.111289521330304 23.262964785924567 -6.676094498623133 1.9160919927209792 0.5152181793151961 1.1078365339170735 0.3061430470745332 0.3238756289261901 0.4472920355959518 3.1716067619449655 0.13581177202336597 0.35995341556417243 2.1081693810843357e-07 6.676094498623133 0.5926183546018774 SLDLLGLEK(ub)LDCGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLDLLGLEKLDCGR 14 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 110184000.0 29208000.0 47250000.0 33726000.0 True False 37810331.775754906 44620495.96391186 27588214.057982925 1.0 1.1801138437119938 0.7296475000960795 25.172277172863218 -6.798196972392431 1.4632597715878521 1.0996057212281458 0.7237024357770557 0.8268354991131273 0.07703738779947536 0.2233443644530981 0.9442788485723462 0.04142145837049632 0.09643891362751772 1.5914867513750566e-07 6.798196972392431 -0.3759032854510901 SLDLTDNALGDGGVAALCEGLK(ub)QK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLDLTDNALGDGGVAALCEGLKQK 24 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 27833800.0 9621200.0 9482300.0 8730300.0 True False 12613486.371833337 8067577.801715906 7826972.302950988 1.0 0.6395993592803402 0.6205241019191237 23.58846375638642 -13.999999999999998 0.41889675248681485 7.864154231676255 0.6198792887012471 0.9998627826216203 0.002044835660994248 29.773494427154468 0.21572281755931214 187.00426702894882 0.0046418917550936885 1.0000000000000041e-14 13.999999999999998 -7.244274942975008 SLDLTDNALGDGGVAALCEGLK(ub)QK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLDLTDNALGDGGVAALCEGLKQK 24 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 108065000.0 47768000.0 29500000.0 30797000.0 True False 46251630.98688125 41279503.840467736 22730341.809804033 1.0 0.8924983391867024 0.49144951918022606 25.463000904979886 -6.946478004586726 0.5962597210794537 1.004556971137115 0.35899256194086193 0.9988950935164025 0.007274284117085865 0.08493162128775167 0.042058698851923995 0.007493702771154577 0.0336626772785856 1.1311546766942249e-07 6.946478004586726 -0.645564409196253 down SLDLTDNALGDGGVAALCEGLK(ub)QK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLDLTDNALGDGGVAALCEGLKQK 24 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 423023700.0 79933700.0 99662000.0 243428000.0 True False 121265266.83623402 81876537.43723983 195314349.10171753 1.0 0.6751853978749928 1.6106371939583088 26.853591147655656 -6.812925721011023 1.4022332860627063 0.8235836964221889 1.6281165021552249 0.8673283663800305 0.14125026523199669 0.2028330357485145 0.7854747628509544 0.07919471048261285 0.18296006396244816 1.5384177390699074e-07 6.812925721011023 0.804532805733036 SLDLTDNALGDGGVAALCEGLK(ub)QK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLDLTDNALGDGGVAALCEGLKQK 24 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 63387200.0 9621200.0 11117000.0 42649000.0 True False 13178417.643153675 10625814.180997115 32576184.58372657 1.0 0.8063042520523953 2.4719344511478765 23.651673817909312 -6.877926469985223 1.0912500658876187 0.882934264969357 2.5854037230911042 0.971976196047619 0.12450552462980095 0.12948496654074676 0.2834930145199659 0.08804428211668394 0.2118446040714706 1.3245657772717345e-07 6.877926469985223 1.7024694581217472 up SLDLTDNALGDGGVAALCEGLK(ub)QK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLDLTDNALGDGGVAALCEGLKQK 24 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 134790600.0 47768000.0 17696000.0 69326600.0 True False 39721208.48120494 17600668.135619026 83822471.53001839 1.0 0.4431050516488493 2.1102699221671726 25.243406180414162 -6.816637890980159 1.3862913804068753 0.6987705195569448 2.1441236688665257 0.876477890053479 0.24356060357949927 0.19789552297625584 0.7481790039182822 0.13809150540181 0.31860938691801743 1.5253240188217158e-07 6.816637890980159 1.445353149309581 up SLDLTDNALGDGGVAALCEGLK(ub)QK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLDLTDNALGDGGVAALCEGLKQK 24 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 331284400.0 79933700.0 75853000.0 175497700.0 True False 103475750.37878858 71631713.86985421 143558919.3584676 1.0 0.6922560465387836 1.3873677536326003 26.624717469748106 -6.786347944046891 1.5108038610778987 0.8271817707132811 1.3940437436441087 0.7893012151470538 0.13054422753118008 0.2408402835980803 1.0860151561789408 0.06802637287370766 0.1597064251582264 1.6355056770411e-07 6.786347944046891 0.5668619729308275 SLDWQIDVDLLNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLDWQIDVDLLNK 13 0 Q15008;Q15008-4;Q15008-3;Q15008-2;C9J7B7;C9J0E9 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 0 26875000.0 7146600.0 11295000.0 8433400.0 False True 10841914.686444268 9279319.001762198 6766534.793509475 1.0 0.855874563684236 0.6241088395548553 23.370116223920963 -6.964075124484324 0.3735853421419629 1.017114039553218 0.45475628796160605 0.9998927913788906 0.0016032381785941905 0.07827623348024251 0.015975203830742257 0.0030392152858875186 0.0196465952845744 1.0862377094034409e-07 6.964075124484324 -0.562357751591612 SLEAASEK(ub)YSEKEDKYEEEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLEAASEKYSEKEDKYEEEIK 21 3 P67936;A0A2R8Y5V9;A0A2R8YE05;K7ENT6;P67936-2;A0A2R8YH90;A0A2R8YHD2;A0A5F9UN72;K7EPB9 P67936 TPM4 Tropomyosin alpha-4 chain 1 21815400.0 5955600.0 9014600.0 6845200.0 True False 9035080.612681197 7405874.198608731 5492243.219642253 1.0 0.8196799249598513 0.6078798247725216 23.107106042466796 -6.969002596714523 0.28099139317386557 1.046107125248536 0.37498988433250674 0.999973521667752 0.000824601738042819 0.07662770102939442 0.010183608395705033 0.003889991146690336 0.019416376248129297 1.0739829908100415e-07 6.969002596714523 -0.6711172409160293 SLEAEDK(ub)MTHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLEAEDKMTHR 11 1 A0A0G2JJ08;A0A0G2JHT6;F6QYZ9;A0A0G2JKD0;A0A0G2JJ73;A0A0A0MSL4;A0A0G2JK37;A0A0G2JK30;A0A0G2JHL1;O95872 A0A0G2JJ08 GPANK1 G patch domain and ankyrin repeat-containing protein 1 1 2540060.0 661070.0 715090.0 1163900.0 True False 866669.1718109862 608401.359398988 1043470.7929171573 1.0 0.7019995393717264 1.204001280830986 19.725121862034513 -6.745880348206303 1.6650380812339634 0.823909278729621 1.2046969331006077 0.6310768731813872 0.1252047198129778 0.30728691546109954 1.6747722903011275 0.05943495289507696 0.14492465339997568 1.7952281592088139e-07 6.745880348206303 0.3807876543709866 SLEAEDK(ub)MTHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLEAEDKMTHR 11 1 A0A0G2JJ08;A0A0G2JHT6;F6QYZ9;A0A0G2JKD0;A0A0G2JJ73;A0A0A0MSL4;A0A0G2JK37;A0A0G2JK30;A0A0G2JHL1;O95872 A0A0G2JJ08 GPANK1 G patch domain and ankyrin repeat-containing protein 1 1 3544640.0 890950.0 871090.0 1782600.0 True False 862667.2799313742 1218920.77967434 1315683.5831463 1.0 1.4129674418291442 1.525134444940306 19.718444711536574 -12.052430577408824 0.21517150457221793 2.4426048915414524e-08 1.5944405286086705 0.9993826741523079 0.005610349480781969 5.3558873107632925 0.1322609576451539 2.4410484449481147 0.06383509605762655 8.862768849585459e-13 12.052430577408824 1.5944405041826215 SLEAEDK(ub)MTHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLEAEDKMTHR 11 1 A0A0G2JJ08;A0A0G2JHT6;F6QYZ9;A0A0G2JKD0;A0A0G2JJ73;A0A0A0MSL4;A0A0G2JK37;A0A0G2JK30;A0A0G2JHL1;O95872 A0A0G2JJ08 GPANK1 G patch domain and ankyrin repeat-containing protein 1 1 14572100.0 1134900.0 4923600.0 8513600.0 True False 1721726.2723036977 4044945.111737614 6830883.228356553 1.0 2.3493543525507175 3.967461807512945 20.715424364219054 -6.968709669419772 0.2873371076038934 0.6735919062516271 5.693032347188709 0.9999704965110722 0.006589294648063548 0.07672363860662625 0.01052129805631818 0.028680667599208464 0.147195355460659 1.0747076259735042e-07 6.968709669419772 5.019440440937082 SLEAEDK(ub)MTHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLEAEDKMTHR 11 1 A0A0G2JJ08;A0A0G2JHT6;F6QYZ9;A0A0G2JKD0;A0A0G2JJ73;A0A0A0MSL4;A0A0G2JK37;A0A0G2JK30;A0A0G2JHL1;O95872 A0A0G2JJ08 GPANK1 G patch domain and ankyrin repeat-containing protein 1 1 3384480.0 890950.0 662930.0 1830600.0 True False 740864.4007772898 659358.6645086983 2213369.9962619194 1.0 0.8899856219531153 2.98755075009641 19.49884998697085 -6.894524122838055 0.9952058375491011 0.8992121402741884 3.184820795368164 0.9836404716192071 0.12328932204057348 0.11555023372735251 0.20100607140596757 0.0937839246074804 0.23795958215184382 1.2748992838399486e-07 6.894524122838055 2.2856086550939754 up SLEAEDK(ub)MTHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLEAEDKMTHR 11 1 A0A0G2JJ08;A0A0G2JHT6;F6QYZ9;A0A0G2JKD0;A0A0G2JJ73;A0A0A0MSL4;A0A0G2JK37;A0A0G2JK30;A0A0G2JHL1;O95872 A0A0G2JJ08 GPANK1 G patch domain and ankyrin repeat-containing protein 1 1 14818700.0 1134900.0 1239800.0 12444000.0 True False 1469150.4222235084 1170804.0401282113 10179319.686222503 1.0 0.7969259120221602 6.928711677335568 20.486550686311503 -6.89923813172831 0.9660503003833343 0.7397061944607171 7.56252748814822 0.9861840751424255 0.33427474458322887 0.11196898920385161 0.18059016536078648 0.2598809052577708 0.6736337281053739 1.2611358407757365e-07 6.89923813172831 6.822821293687503 up SLEDQVEMLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLEDQVEMLR 10 0 K7ELL7;P14314-2;P14314 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 12537700.0 3855900.0 1728300.0 6953500.0 False True 3733496.565112953 2418419.202965433 5132169.74947145 1.0 0.6477625359465855 1.3746282231590006 21.832095973058323 -6.774902550781615 1.5554217112111757 0.7992384626108147 1.3795246839862212 0.7490679751597945 0.14867065750419287 0.2585639614203624 1.2351136292987706 0.07530748159811378 0.17848883102022062 1.6791807590255012e-07 6.774902550781615 0.5802862213754065 SLEEEGAAHSGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLEEEGAAHSGKR 13 1 Q03989;Q03989-5 Q03989 ARID5A AT-rich interactive domain-containing protein 5A 1 11055300.0 2734900.0 3220000.0 5100400.0 True False 3585480.3848092747 2739588.5514616896 4572659.534491506 1.0 0.7640785215472372 1.2753268861446423 21.773734994346874 -6.781230346243022 1.5311141155779058 0.8666298488683742 1.279531830633085 0.7717164475863922 0.09982129601533758 0.24866236161915836 1.151502276225415 0.05134550713159313 0.12102795281558527 1.654891989471844e-07 6.781230346243022 0.4129019817647107 SLEEEGAAHSGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLEEEGAAHSGKR 13 1 Q03989;Q03989-5 Q03989 ARID5A AT-rich interactive domain-containing protein 5A 1 23364600.0 5299300.0 6158300.0 11907000.0 True False 5131076.622190161 8617341.305110252 8788199.497656787 1.0 1.6794411659812645 1.7127398682083237 22.29083013872963 -11.293453078907625 0.5048440123911662 3.7253689588570236e-16 1.7110776887988477 0.9998429287245718 0.004116041844895874 3.56822460941821 0.24749585711720914 3.9900483719311683 0.006713383776641045 5.087997873065444e-12 11.293453078907625 1.7110776887988473 SLEEEGAAHSGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLEEEGAAHSGKR 13 1 Q03989;Q03989-5 Q03989 ARID5A AT-rich interactive domain-containing protein 5A 1 13166700.0 3116400.0 2681300.0 7369000.0 True False 4727806.63935787 2202801.0659074797 5912513.920052561 1.0 0.46592452567109716 1.2505828539670558 22.172739601848086 -6.723423228930813 1.746821453686841 0.6762703587701049 1.249616084305456 0.5286823904908022 0.2246520336622328 0.3487173753954986 2.0812789689525997 0.10203973584511476 0.2551493562552253 1.8905003890337194e-07 6.723423228930813 0.5733457255353511 SLEEEGAAHSGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLEEEGAAHSGKR 13 1 Q03989;Q03989-5 Q03989 ARID5A AT-rich interactive domain-containing protein 5A 1 10598500.0 2734900.0 3035600.0 4828000.0 True False 3746066.4378935043 2901477.154613196 3687725.835781194 1.0 0.7745396945615199 0.9844261699359724 21.836945055869766 -10.482024613235835 7.772752202964762 1.000011348911987 0.879482932279233 0.30536712097430285 0.08568579476310591 1.6853110178154827e-05 1.1231201767363285e-06 0.08297272329308243 0.027654971343671324 3.295910323829175e-11 10.482024613235835 -0.12052841663275404 SLEEEGAAHSGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLEEEGAAHSGKR 13 1 Q03989;Q03989-5 Q03989 ARID5A AT-rich interactive domain-containing protein 5A 1 19105900.0 5299300.0 7941800.0 5864800.0 True False 4406602.748795201 7899015.94707612 7091102.564228625 1.0 1.7925409657668308 1.6091994147117952 22.071235414163905 -10.080949913605375 4.559394839205949 0.9999590572290831 1.7008701902134786 0.9511829053389576 0.07484887492298246 26001507.25649439 1.3137037627500334 12343.69012125519 0.025622760729099418 8.299464782167447e-11 10.080949913605375 0.7009111329843956 SLEEEGAAHSGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLEEEGAAHSGKR 13 1 Q03989;Q03989-5 Q03989 ARID5A AT-rich interactive domain-containing protein 5A 1 21778800.0 3116400.0 2865400.0 15797000.0 True False 4034241.2334279185 2705937.9711109656 12922108.090907795 1.0 0.6707427281961803 3.2031074353795654 21.943865923940535 -6.874205593694802 1.1116574950496123 0.808111951904393 3.3637350620646713 0.9687008866571168 0.19889312564547965 0.13288395818110796 0.3043875175276699 0.1384717372048656 0.33043951334749216 1.3359629260146558e-07 6.874205593694802 2.5556231101602784 up SLEEIYLFSLPIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLEEIYLFSLPIK 13 0 P15880;H0YEN5;E9PQD7;E9PMM9;E9PPT0;H3BNG3;H0YE27 P15880 RPS2 40S ribosomal protein S2 0 66769000.0 11566000.0 38969000.0 16234000.0 False True 17546467.587861992 32014677.483813304 13025342.784385022 1.0 1.8245653903558283 0.7423341888708973 24.064677284119373 -6.703083723125809 1.8202588897315424 1.5104861638693352 0.7454046476181396 0.4320195949710556 0.34786908935951294 0.3891571923693178 2.508971147486879 0.15235429431531586 0.3902743416400236 1.981145064593567e-07 6.703083723125809 -0.7650815162511956 SLEEIYLFSLPIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLEEIYLFSLPIK 13 0 P15880;H0YEN5;E9PQD7;E9PMM9;E9PPT0;H3BNG3;H0YE27 P15880 RPS2 40S ribosomal protein S2 0 37943000.0 11566000.0 13787000.0 12590000.0 False True 14972414.99994458 13019741.33025299 10298749.184308993 1.0 0.8695819164978517 0.6878482318548552 23.835803606211822 -6.966452597501555 0.33218004270786805 1.0215856285862763 0.5298757858777889 0.999940029894135 0.0009912828662348978 0.07747142740172877 0.013140455252081714 0.002631578222254171 0.015823668186888455 1.0803075281624495e-07 6.966452597501555 -0.4917098427084874 SLEGMQK(ub)MEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLEGMQKMEK 10 1 Q9UJX3;H0YIW2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 3548850.0 651550.0 1283400.0 1613900.0 True False 854188.3596191745 1091921.7226540172 1446909.1096219595 1.0 1.2783149177317659 1.6938993529097488 19.704194712344147 -6.9653326986387984 0.3523002698979374 0.9608868935443331 2.0254002572978864 0.999919834830045 0.0025528594752976404 0.07784829350397772 0.014463187239412848 0.005672046769058429 0.035666785595042494 1.0830968714366796e-07 6.9653326986387984 1.0645133637535533 SLEGMQK(ub)MEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLEGMQKMEK 10 1 Q9UJX3;H0YIW2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 4492680.0 1755000.0 767080.0 1970600.0 True False 1699288.4856384327 1073379.0442693538 1454440.7432671955 1.0 0.6316638130258848 0.8559116098057674 20.696499366795916 -10.30677826673662 5.827521895043929 1.0000233794950504 0.7437877114158251 0.6351074852531355 0.09154877967567861 2.781078658134463e-05 3.3082489684420704e-06 0.08864980415824245 0.02954724158745906 4.934256629167718e-11 10.30677826673662 -0.25623566807922527 SLEGMQK(ub)MEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLEGMQKMEK 10 1 Q9UJX3;H0YIW2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 14659900.0 2107800.0 7199000.0 5353100.0 True False 3197686.7008209815 5914282.203956276 4295057.438652917 1.0 1.8495502396897825 1.3431764398776758 21.608597164392048 -10.450380102957583 5.299970984822423 0.9992713123477246 1.5963633397837353 0.6490422645114996 0.20672623810900806 0.0017820009812352493 0.00018479763850073842 0.2003903928122753 0.06672060645168784 3.5450298552603115e-11 10.450380102957583 0.5970920274360108 SLEGMQK(ub)MEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLEGMQKMEK 10 1 Q9UJX3;H0YIW2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 3104430.0 651550.0 990880.0 1462000.0 True False 892445.642476694 947099.6451980238 1116705.7108351493 1.0 1.061240707691345 1.25128708986252 19.76740477386704 -6.9506872200930765 0.5512456896650989 0.9973909161666062 1.3240841072437128 0.9992541246692689 0.002921847674824589 0.08321091289201615 0.03482911031953756 0.003166252460154185 0.015769700763883975 1.1202443956538272e-07 6.9506872200930765 0.3266931910771066 SLEGMQK(ub)MEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLEGMQKMEK 10 1 Q9UJX3;H0YIW2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 4579000.0 1755000.0 1804700.0 1019300.0 True False 1459360.2596825224 1794977.722895099 1232430.9172892908 1.0 1.2299757451841185 0.8445008071943805 20.476904642230192 -6.745141361890936 1.6681303881389782 1.1360178266717669 0.8440243328458367 0.6276536998989 0.09662273732314236 0.308608657303792 1.6880427630323522 0.04579025613767926 0.11172611948245353 1.7982854819181682e-07 6.745141361890936 -0.2919934938259302 SLEGMQK(ub)MEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLEGMQKMEK 10 1 Q9UJX3;H0YIW2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 12542500.0 2107800.0 4365800.0 6068900.0 True False 2728588.650949607 4122839.392153368 4964422.472172582 1.0 1.5109787218086286 1.8194103645651596 21.379723486484497 -9.347898531426168 0.11620703393139621 1.5526743903925846e-16 2.557528261465292 0.9999177789860595 0.0030640417641971123 0.8066422654620712 0.04382523082643784 0.5979427748773906 0.339924880128448 4.488502470664198e-10 9.347898531426168 2.557528261465292 SLEGPLAPSTDEPSQK(ub)TGDLVEILNGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLEGPLAPSTDEPSQKTGDLVEILNGEK 28 1 A0A0C4DGF2;Q8WZ60 A0A0C4DGF2 KLHL6 Kelch-like protein 6 1 28652900.0 4549900.0 10226000.0 13877000.0 True False 4405465.914989341 14309295.12788552 10242197.398923602 1.0 3.2480775936091066 2.3248840409989606 22.070863173645655 -10.543930594155237 6.286776677469461 0.9975745526463464 2.7864808173040334 0.8331349355338908 0.3768921896203525 0.012814162884915393 0.0009295935372863399 0.36496749824767627 0.12164143114293943 2.8580472595960397e-11 10.543930594155237 1.788906264657687 SLEGPLAPSTDEPSQK(ub)TGDLVEILNGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLEGPLAPSTDEPSQKTGDLVEILNGEK 28 1 A0A0C4DGF2;Q8WZ60 A0A0C4DGF2 KLHL6 Kelch-like protein 6 1 70414000.0 11015000.0 25999000.0 33400000.0 True False 16710560.304366214 21359275.318885855 26798475.360259924 1.0 1.2781902539381043 1.6036850274408747 23.994256771924128 -6.969056894783866 0.279801625722791 0.9281204690519359 1.963670566147915 0.9999740604672107 0.0012564790733715489 0.07660998578992739 0.010121134567484077 0.0060191555200259615 0.029883812194149525 1.0738487234867532e-07 6.969056894783866 1.035550097095979 SLEGPLAPSTDEPSQK(ub)TGDLVEILNGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLEGPLAPSTDEPSQKTGDLVEILNGEK 28 1 A0A0C4DGF2;Q8WZ60 A0A0C4DGF2 KLHL6 Kelch-like protein 6 1 22120800.0 4549900.0 8155600.0 9415300.0 True False 3783443.4447461534 8111664.164040147 11383995.698571429 1.0 2.1439898025446475 3.0088980752123353 21.85126844907993 -7.525675146654786 0.16321564085071413 3.162552962839802e-16 4.696813594029316 0.9999770111732293 0.003944869922609909 0.13555694813258815 0.01574557105628659 0.14988398602161523 0.2638228263966638 2.980745200534863e-08 7.525675146654786 4.696813594029316 SLEGPLAPSTDEPSQK(ub)TGDLVEILNGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLEGPLAPSTDEPSQKTGDLVEILNGEK 28 1 A0A0C4DGF2;Q8WZ60 A0A0C4DGF2 KLHL6 Kelch-like protein 6 1 65082000.0 11015000.0 26591000.0 27476000.0 True False 14259134.638110787 25111187.47463241 22475649.92756742 1.0 1.7610597074746064 1.5762281862109726 23.765383094016578 -10.081504047006355 4.500668368474736 0.9999589017575797 1.6686439466630572 0.9457972221266018 0.07545715283913407 11628030.535633171 13023406.428443596 4567.132098942214 0.025830990174592394 8.28888192179085e-11 10.081504047006355 0.6686850449054774 SLEGTEAQVFK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLEGTEAQVFKAK 13 1 Q13045;Q13045-2;Q13045-3 Q13045 FLII Protein flightless-1 homolog 1 6047400.0 848900.0 1601600.0 3596900.0 True False 1112916.120759294 1362647.5229879045 3224727.291901126 1.0 1.22439373243891 2.897547471682804 20.08591343179312 -6.93143054060192 0.7349599649225533 0.9758587813462927 3.253888788921576 0.9968119303648991 0.04780119331259439 0.09190180938296658 0.0740922133699047 0.04392573612454276 0.15021834040349494 1.1710338780225247e-07 6.93143054060192 2.2780300075752833 up SLEIGSNK(ub)IEDAGMQLLCGGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLEIGSNKIEDAGMQLLCGGLR 22 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 10236300.0 4936700.0 1755200.0 3544400.0 True False 4779987.160712954 2456060.5132470834 2616015.3102792227 1.0 0.5138215712028716 0.5472850077465551 22.188575312383623 -10.351078695594293 6.939102962582836 1.0000147453098416 0.5305532894747135 0.9962035480931147 0.013661390762004727 3.1165129538661386e-06 2.914268911572826e-07 0.01322799949402891 0.0044091949089396796 4.4557550132964056e-11 10.351078695594293 -0.4694614558351281 SLEIGSNK(ub)IEDAGMQLLCGGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLEIGSNKIEDAGMQLLCGGLR 22 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 124359000.0 21352000.0 37987000.0 65020000.0 True False 32392545.040292997 31207923.056214314 52168768.50072163 1.0 0.9634291784543284 1.610517742148048 24.94915848747785 -6.893512816776269 1.001352149167731 0.9681006921441239 1.6701636743430937 0.983053010506044 0.03863713449970484 0.11634142496682469 0.20556307401410542 0.029255019159148417 0.0739200716494487 1.2778714968265807e-07 6.893512816776269 0.7020629821989698 SLEIGSNK(ub)IEDAGMQLLCGGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLEIGSNKIEDAGMQLLCGGLR 22 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 91376000.0 21352000.0 23418000.0 46606000.0 True False 27640584.91084353 22114767.713923544 38124186.21794325 1.0 0.8000832032048576 1.379282903777733 24.7202848095703 -6.813515964953487 1.3997576993617284 0.8914899655022489 1.3902454950807652 0.8687884675187554 0.08701049242380883 0.20205105203922027 0.7795636925153372 0.04886870709110497 0.11287124646198163 1.536328315844657e-07 6.813515964953487 0.4987555295785163 SLEK(ub)VCADLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLEKVCADLIR 11 1 P60866;P60866-2;E5RJX2 P60866 RPS20 40S ribosomal protein S20 1 8042200.0 1649000.0 3724800.0 2668400.0 True False 2161854.9689387167 3169074.3591566808 2392299.5651002144 1.0 1.4659051623210513 1.10659577051768 21.043838310430427 -9.852306015401533 5.674815645821906 0.9999999121393779 1.286250466420384 0.45835886940082615 0.1466874449549356 1.6304325510062567e-07 3.281934186643777e-08 0.14202955017838453 0.04734316928349136 1.4050571347499062e-10 9.852306015401533 0.2862505542810061 SLEK(ub)VCADLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLEKVCADLIR 11 1 P60866;P60866-2;E5RJX2 P60866 RPS20 40S ribosomal protein S20 1 16288600.0 4205200.0 4423600.0 7659800.0 True False 6379595.841300119 3634174.018255446 6145837.172590392 1.0 0.5696558384981996 0.9633583890696611 22.605033598922287 -10.417865299772076 8.66716857486509 1.00000210287798 0.7665071137839303 0.3192531679191325 0.16072839322206176 6.531229693479319e-06 4.385386665243224e-07 0.15562600027526088 0.05187486585097688 3.820627525657549e-11 10.417865299772076 -0.23349498909404964 SLEK(ub)VCADLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLEKVCADLIR 11 1 P60866;P60866-2;E5RJX2 P60866 RPS20 40S ribosomal protein S20 1 6695900.0 1649000.0 3058400.0 1988500.0 True False 2258679.8625494135 2923269.775223677 1518857.2544430192 1.0 1.294238206880779 0.6724535334231284 21.10704837195332 -6.778022214997016 1.5435365616686143 1.1670340309842646 0.6678272340903213 0.760333043205907 0.12433004144907009 0.2536650395226914 1.1935780078848197 0.06345033045079995 0.14996805193766188 1.667161931834565e-07 6.778022214997016 -0.4992067968939433 SLEK(ub)VCADLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLEKVCADLIR 11 1 P60866;P60866-2;E5RJX2 P60866 RPS20 40S ribosomal protein S20 1 8161600.0 4165200.0 2514300.0 1482100.0 True False 3463548.349646516 2500754.966850526 1792000.257543864 1.0 0.72202109351404 0.5173885497301496 21.723819382700707 -7.4529963241969375 0.13493663672774087 1.3320916566775218 6.200408667050768e-13 0.9999922490992142 0.0005506043640854274 0.12770573542167643 0.010892470541475682 0.03804193689456739 0.06342522305057628 3.523738534690716e-08 7.4529963241969375 -1.3320916566769019 SLEK(ub)VCADLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLEKVCADLIR 11 1 P60866;P60866-2;E5RJX2 P60866 RPS20 40S ribosomal protein S20 1 12990000.0 4205200.0 4856300.0 3928500.0 True False 5443714.296884565 4586042.635969208 3213553.3098139726 1.0 0.8424473412562812 0.5903236530346729 22.376159921014736 -6.964159788753983 0.3721911152164611 1.018913223520261 0.4050514314572309 0.9998947625093835 0.0017308976699069688 0.07824725418183684 0.01587240772161026 0.0033125254471970443 0.02138782314013735 1.0860259716020891e-07 6.964159788753983 -0.61386179206303 SLEQNIQLPAALLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLEQNIQLPAALLSR 15 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 15681100.0 1848000.0 8101800.0 5731300.0 False True 2422745.8960574577 6893043.020569059 5138280.054511643 1.0 2.8451365996682236 2.120849760956435 21.208211668409017 -10.412267237878996 5.7846359896510045 0.9994093651541087 2.4829931803123313 0.848250204084361 0.29568886370957015 0.002253085318046236 0.00022891897422795503 0.28639563096969545 0.09543317040051227 3.870194238945041e-11 10.412267237878996 1.4835838151582226 SLEQNIQLPAALLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLEQNIQLPAALLSR 15 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 16731700.0 6419200.0 3182500.0 7130000.0 False True 6215426.00969243 4453288.846518249 5262439.10458494 1.0 0.7164897208290668 0.8466739200786257 22.56742184732881 -10.03840276326577 4.526525179251842 1.000009464305155 0.7815818204379096 0.7896146659566161 0.05314747684209493 73613900.54138805 15879.151136282262 7439.009473214584 0.0181937949555707 9.153711841531749e-11 10.03840276326577 -0.21842764386724534 SLEQNIQLPAALLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLEQNIQLPAALLSR 15 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 22441000.0 1848000.0 10271000.0 10322000.0 False True 2531255.5403222046 9817193.258345006 7884156.188262938 1.0 3.8783888477318142 3.1147215532649697 21.27142172993191 -10.762557033988143 11.38503879419134 0.9950563959217483 3.4965552004983866 0.9344259240790261 0.3117658674492528 0.0385506444702905 0.0008039992764991045 0.2974655927975829 0.1006220010455721 1.7275990876042083e-11 10.762557033988143 2.5014988045766384 SLEQNIQLPAALLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLEQNIQLPAALLSR 15 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 12203500.0 6419200.0 3276900.0 2507400.0 False True 5337849.218777229 3259246.689286279 3031685.74709229 1.0 0.6105917487929516 0.567960169505645 22.347827122763086 -13.999999999999972 0.3123606284760988 4.816586821724006 0.5587559168333637 0.9996771722554968 0.0034928203556394135 17.439418477966758 0.1779170601605425 43.31641493874923 0.014631839319684748 1.0000000000000655e-14 13.999999999999972 -4.257830904890643 SLESLDTSLFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLESLDTSLFAK 12 0 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 0 15889300.0 2158600.0 6730300.0 7000400.0 False True 2829945.503912133 5726165.474503928 6276065.760578451 1.0 2.0234189904321633 2.217733787418302 21.432342840758466 -10.698280955210816 0.3307876652764423 7.019360028545884e-13 2.261105181451349 0.9991958287858921 0.015147891897284554 2.330796776948908 0.16205466506386018 1.9376106493979461 0.06177852663428795 2.003175707101191e-11 10.698280955210816 2.261105181450647 SLESLDTSLFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLESLDTSLFAK 12 0 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 0 8417900.0 5240400.0 3177500.0 0.0 False True 5074046.370449931 4446292.3204436 0.0 1.0 0.8762813730551962 0.0 22.27470527321804 -7.144584379418268 0.9431621752920144 0.994733276759726 1.4817920663055234e-20 0.9896929591806936 0.04519004408011897 0.08740011222346512 0.14723088388258204 0.03775248574138541 0.06634121934301883 7.168290887593614e-08 7.144584379418268 -0.994733276759726 down SLESLDTSLFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLESLDTSLFAK 12 0 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 0 10606900.0 2158600.0 4155900.0 4292400.0 False True 2956692.7539715935 3972278.596276511 3278623.524752935 1.0 1.3434871076613308 1.108882050848505 21.495552902281357 -10.338827604785926 4.632662310742102 0.9998043523859045 1.2261845792553132 0.553439576867942 0.09577711337936487 0.00019370568802271716 2.7645465210792615e-05 0.09281559769794825 0.03091193042198416 4.58323784367009e-11 10.338827604785926 0.22638022686940873 SLESLDTSLFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLESLDTSLFAK 12 0 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 0 10105000.0 5240400.0 2105100.0 2759500.0 False True 4357624.78908278 2093759.4084703645 3336498.6915135877 1.0 0.4804818013969193 0.7656691094360777 22.055110548652316 -10.111436097966997 5.376622283180682 1.0000062919019053 0.6230754554163067 0.6996180558671787 0.1164272309696611 8.781165362276399e-06 1.45127931594765e-06 0.11273206235385162 0.037576727215779655 7.736845102373373e-11 10.111436097966997 -0.37693083648559855 SLESLDTSLFAKNPK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLESLDTSLFAKNPK 15 1 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 1 14554100.0 6150500.0 4276700.0 4126900.0 True False 5955255.744113487 5984408.612695878 3045941.0856537987 1.0 1.0048953176546964 0.5114710797541449 22.505732034229982 -6.904658724710237 0.9313350309844245 1.0179758505425398 0.4544831572405247 0.9887452182339826 0.02455496026585875 0.10805717579230861 0.1587070063942479 0.019587002113496718 0.052263432366019845 1.2454929548605736e-07 6.904658724710237 -0.5634926933020151 SLESLDTSLFAKNPK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLESLDTSLFAKNPK 15 1 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 1 27583200.0 4033700.0 5669500.0 17880000.0 True False 6119417.802970683 4657733.428994321 14346010.162917601 1.0 0.7611399611795121 2.344342325499217 22.544962971797485 -6.868458935240724 1.1421333444288642 0.8660739825936018 2.4344195495342986 0.9631251786978094 0.13382158459987653 0.13834550255918787 0.33824124621362145 0.09100969943935312 0.21492447868311873 1.3537580893548696e-07 6.868458935240724 1.568345566940697 up SLETENAGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLETENAGLR 10 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 10156800.0 3513500.0 1405200.0 5238100.0 False True 3401965.8656926686 1966303.6880211954 3866084.470368361 1.0 0.5779904224938011 1.1364265906827946 21.697937234827833 -6.704570121029955 1.814470451500982 0.7391333201177354 1.1349214042425373 0.4393400679716497 0.1779908090448065 0.3860890891169558 2.4742560267368914 0.07816456229802275 0.19989992418586233 1.974376071626375e-07 6.704570121029955 0.39578808412480193 SLETENAGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLETENAGLR 10 0 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 44722500.0 1511400.0 41928000.0 1283100.0 False True 2292904.2981406385 34445620.81504075 1029494.7225972911 1.0 15.02270323404836 0.4489915795579121 21.12874470990392 -6.65065686126154 2.006448805923642 9.999998494718046 0.5105734997360446 0.2181891739823204 5.963042502838222 0.4968857649318011 3.8351107043517287 2.4160397709186787 6.621122313711894 2.2353376793240412e-07 6.65065686126154 -9.489424994982 SLETENSALQLQVTER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLETENSALQLQVTER 16 0 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 0 8882800.0 1994600.0 4549100.0 2339100.0 False True 2614939.915733878 3870392.0122529184 2097072.3702315695 1.0 1.480107435343003 0.8019581473416111 21.318346366936492 -6.716495586561828 1.771905132119719 1.2931650857198087 0.8032109601528941 0.49606827634325423 0.20212034817271687 0.36210498106719224 2.219875060400722 0.09064150650002631 0.22848906072459033 1.9208984824320248e-07 6.716495586561828 -0.48995412556691464 SLETENSALQLQVTER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLETENSALQLQVTER 16 0 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 0 16587900.0 4290500.0 2280400.0 10017000.0 False True 4154300.4260009634 3190975.6121288976 7393247.196441424 1.0 0.7681138302269133 1.7796611795739468 21.98617412046809 -6.84642542003833 1.2523587374307532 0.8765423043041576 1.8173616895357119 0.9349130818708244 0.11038470452014625 0.16144120276199467 0.4890775320987244 0.06903198700336187 0.15940822205008454 1.4242118008514195e-07 6.84642542003833 0.9408193852315543 SLETENSALQLQVTER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLETENSALQLQVTER 16 0 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 0 41369800.0 4057300.0 31221000.0 6091500.0 False True 6155220.728361795 25649368.61921363 4887512.355000708 1.0 4.167091604209648 0.7940433935179956 22.553379162508826 -6.660373372531777 1.9716730622738283 3.0379835318457533 0.8081223046802876 0.23719127810943286 1.3483532198117822 0.48353115716337186 3.613928905199332 0.5524450256668753 1.4946793258929063 2.18588156537392e-07 6.660373372531777 -2.2298612271654656 SLETENSALQLQVTER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLETENSALQLQVTER 16 0 P20700;E9PBF6;A0A0D9SFE5;A0A0D9SFY5 P20700 LMNB1 Lamin-B1 0 8029600.0 1994600.0 2994900.0 3040100.0 False True 2732057.5220382423 2862575.415190092 2322090.992824854 1.0 1.0477727471325264 0.849942204398561 21.381556428459383 -6.842926328412339 1.2687642791603713 1.025412053481011 0.843050448190441 0.9293651621373565 0.02240075421545618 0.1654085245244928 0.5159638463722442 0.01383725463304636 0.0319073014653915 1.4357329634015872e-07 6.842926328412339 -0.18236160529057 SLETK(ub)TGADVCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLETKTGADVCR 12 1 Q86XI2;Q86XI2-2;F8WE06 Q86XI2 NCAPG2 Condensin-2 complex subunit G2 1 6877480.0 1944000.0 1487900.0 3445580.0 True False 2548602.825722778 1265911.1197887752 3089064.43393719 1.0 0.49670788520363723 1.2120619198721707 21.28127513059874 -6.717642924981023 1.7679367708299438 0.693034635384059 1.2107921273060231 0.5013296663203618 0.21185038399842324 0.3599060714747287 2.1971946961971 0.09519695502205228 0.23963238030172965 1.9158304650513684e-07 6.717642924981023 0.5177574919219642 SLETK(ub)TGADVCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLETKTGADVCR 12 1 Q86XI2;Q86XI2-2;F8WE06 Q86XI2 NCAPG2 Condensin-2 complex subunit G2 1 30026520.0 4853920.0 6813400.0 18359200.0 True False 7363751.509084829 5597495.536662821 14730496.072876798 1.0 0.7601418284901469 2.0004064578636918 22.812009512869718 -6.856563485016611 1.2029087031890708 0.8708640132990025 2.056659193640784 0.9493266919054288 0.12091244819261472 0.15039107097441398 0.41546986550279347 0.07849712615861873 0.18259213090476567 1.3913503928609588e-07 6.856563485016611 1.1857951803417817 up SLETK(ub)TGADVCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLETKTGADVCR 12 1 Q86XI2;Q86XI2-2;F8WE06 Q86XI2 NCAPG2 Condensin-2 complex subunit G2 1 6478850.0 1944000.0 964650.0 3570200.0 True False 2662749.334624655 922028.5733290345 2726992.2905770554 1.0 0.34626938455662215 1.0241265503729649 21.34448519212163 -10.968357018524262 12.985569725343076 1.1222180590930353 0.6851979674745106 0.22334073315650427 0.2767340291232012 0.09510763902347734 0.0002317561926513622 0.026025726068539416 0.08931552384358636 1.0755806523149311e-11 10.968357018524262 -0.43702009161852473 SLETK(ub)TGADVCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLETKTGADVCR 12 1 Q86XI2;Q86XI2-2;F8WE06 Q86XI2 NCAPG2 Condensin-2 complex subunit G2 1 19040320.0 4853920.0 1208800.0 12977600.0 True False 6283495.125067528 1141529.217379402 10615809.961420858 1.0 0.18167105960269747 1.6894753238639253 22.583135834962167 -6.759331225411844 1.615170791804089 0.5242713671112393 1.6947699277672652 0.6881701302283734 0.3441566514315382 0.28403734387542445 1.4602993845070589 0.16813868750610295 0.4043015076603975 1.740478947816409e-07 6.759331225411844 1.1704985606560259 SLEVILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLEVILR 7 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 15623400.0 3915100.0 5377400.0 6330900.0 False True 5132734.013882332 4575112.880941031 5675839.198280975 1.0 0.8913598227702582 1.1058120648624545 22.291296069148782 -6.769003478135742 1.578415838063132 0.9376060828775753 1.1069684595223712 0.7266552382155493 0.04577442833201209 0.2680579715065995 1.3178766990562831 0.022861374680498172 0.05446619101719799 1.7021448763667148e-07 6.769003478135742 0.16936237664479592 SLEVILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLEVILR 7 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 10387700.0 3508700.0 2611500.0 4267500.0 False True 3397318.2390652755 3654285.568792593 3149713.727744213 1.0 1.0756382863319918 0.9271176575470929 21.69596493632457 -6.768297458396755 1.5813349378647703 1.0434792197243656 0.9263427242893275 0.7238689786267881 0.031863514053084255 0.269194105257889 1.3282879747364478 0.01588618617478975 0.037869493018169054 1.704914253561336e-07 6.768297458396755 -0.11713649543503812 SLEVILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLEVILR 7 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 59225000.0 20653000.0 24398000.0 14174000.0 False True 31332110.936547928 20043986.277555935 11372502.687315114 1.0 0.6397266471495622 0.3629663737099004 24.901138635806777 -7.740613260263088 0.20764108381446642 1.2100753297379299 3.171496817713929e-12 0.999886934188359 0.002773268285441303 0.12903383362167872 0.027645574234271584 0.05051809231909112 0.08514997695273245 1.8171331016229685e-08 7.740613260263088 -1.2100753297347584 down SLEVILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLEVILR 7 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 20434500.0 3915100.0 9286800.0 7232600.0 False True 5362618.271599274 8876478.468659168 5524408.8400727045 1.0 1.6552508530524155 1.030170069969418 22.354506130671673 -10.196403085891795 4.229519066876712 0.9998645666016114 1.3427104614369325 0.2861191358669617 0.2551881611685006 36553536.682585455 44061177.71041041 37547.0286928784 0.08735769193713559 6.36204759986438e-11 10.196403085891795 0.34284589483532113 SLEVILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLEVILR 7 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 8593100.0 3508700.0 3122500.0 1961900.0 False True 2917639.511765275 3105678.4727322757 2372124.219199312 1.0 1.0644490041380166 0.8130285491520824 21.476370211758848 -6.838719854179617 1.2885347236756908 1.0342914665670186 0.8049771851853013 0.9221941880653652 0.029742264187981763 0.17030270650386597 0.5498447662694003 0.018104275872766643 0.04169075073797514 1.4497066992055998e-07 6.838719854179617 -0.2293142813817174 SLEVILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLEVILR 7 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 49672000.0 20653000.0 15960000.0 13059000.0 False True 26735715.63149361 15071811.970032463 10682395.996655388 1.0 0.5637332539652864 0.39955526696550997 24.672264957899227 -13.999999999999998 0.13559775351562411 3.077319206902373 0.18518227353111122 0.9996210532258727 0.0049324500797630665 11.932052652250809 0.11502913795328695 6.5767057364371375 0.1911358048041337 1.0000000000000041e-14 13.999999999999998 -2.892136933371262 SLFEQYGK(ub)VLECDIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLFEQYGKVLECDIIK 16 1 Q9BQ04;E9PLB0;E9PM61;U3KQD5;Q9BWF3;E9PB51;D6R9K7;J3QRR5;Q9BWF3-3;Q9BWF3-4;Q9BWF3-2 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 1 11076200.0 2755200.0 4387800.0 3933200.0 True False 2667737.6841202313 6139871.422074726 2902976.9265292464 1.0 2.3015274172653664 1.0881793003147506 21.347185384113473 -6.629563275833143 2.082053607698264 1.8577154085115852 1.0930446031149834 0.1160228297115119 0.5583418613653612 0.5600493557159835 4.625990765539709 0.21937823384967384 0.6185314729448308 2.346587344718871e-07 6.629563275833143 -0.7646708053966018 SLFEQYGK(ub)VLECDIIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLFEQYGKVLECDIIK 16 1 Q9BQ04;E9PLB0;E9PM61;U3KQD5;Q9BWF3;E9PB51;D6R9K7;J3QRR5;Q9BWF3-3;Q9BWF3-4;Q9BWF3-2 Q9BQ04;Q9BWF3 RBM4B;RBM4 RNA-binding protein 4B;RNA-binding protein 4 1 7674400.0 2755200.0 1941100.0 2978100.0 True False 2291070.8760554316 1930642.9090218167 3600806.9408213864 1.0 0.8426814417657088 1.571669815392593 21.12759065954775 -6.850221251288241 1.2340237792289634 0.9160342056947608 1.600936775504084 0.9406293735967461 0.07632026746100291 0.15721097735283238 0.4605813030938014 0.04839249915283308 0.11199898147456702 1.4118181107596403e-07 6.850221251288241 0.6849025698093232 SLFFGSILAPVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLFFGSILAPVR 12 0 Q99638 Q99638 RAD9A Cell cycle checkpoint control protein RAD9A 0 1610790.0 351900.0 675980.0 582910.0 False True 461344.30780444795 575126.4189494026 522596.06486754824 1.0 1.2466316571379137 1.1327679913394821 18.815484330855263 -10.248229719451528 4.81595933630568 0.9999545460387204 1.1896998242390324 0.787272815574332 0.046484646909311006 2.2691875815434187e-05 3.5421525289065263e-06 0.04501933869349116 0.01500285527767721 5.646382312160206e-11 10.248229719451528 0.18974527820031206 SLFFGSILAPVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLFFGSILAPVR 12 0 Q99638 Q99638 RAD9A Cell cycle checkpoint control protein RAD9A 0 2305430.0 351900.0 852630.0 1100900.0 False True 482006.93973992654 814957.9873296376 840890.0937472058 1.0 1.6907598628545875 1.7445601389077916 18.878694392378154 -11.292854551281764 0.43530468788770704 1.2892385328463205e-23 1.7458826354424666 0.9997051243159683 0.005821636617651053 3.465720568830267 0.21472651600384782 3.3457685432812263 0.012551281408239754 5.095014786335637e-12 11.292854551281764 1.7458826354424666 SLFGHTVGGAAGVVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLFGHTVGGAAGVVSR 16 0 Q709C8-3;Q709C8;Q709C8-4;Q709C8-2;A0A3B3IU50 Q709C8-3 VPS13C Vacuolar protein sorting-associated protein 13C 0 7056700.0 2215400.0 2117900.0 2723400.0 False True 2904410.853964116 1801917.5755095421 2441608.6926974705 1.0 0.6204072585151567 0.8406554084333541 21.469814118749678 -10.211044573479342 5.4828572905068595 1.0000127285303098 0.7305313334742318 0.666206373494026 0.0899159306820156 1.399084491066928e-05 2.013160602077335e-06 0.08706483519144015 0.029020241840836895 6.151137377457525e-11 10.211044573479342 -0.26948139505607793 SLFGHTVGGAAGVVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLFGHTVGGAAGVVSR 16 0 Q709C8-3;Q709C8;Q709C8-4;Q709C8-2;A0A3B3IU50 Q709C8-3 VPS13C Vacuolar protein sorting-associated protein 13C 0 7401100.0 2215400.0 2190200.0 2995500.0 False True 3034493.2489338783 2093429.7219771433 2288024.5942590237 1.0 0.6898778643559801 0.7540054983028501 21.53302418027257 -10.801009402677348 7.126655467496561 1.010616918022443 0.721941681329415 0.9616388232412647 0.026179996930302086 0.0044500609176066795 0.00012425450824236494 0.025542623858680905 0.0084495576762351 1.5812138048861302e-11 10.801009402677348 -0.28867523669302786 SLFGHTVGGAAGVVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLFGHTVGGAAGVVSR 16 0 Q709C8-3;Q709C8;Q709C8-4;Q709C8-2;A0A3B3IU50 Q709C8-3 VPS13C Vacuolar protein sorting-associated protein 13C 0 3198840.0 1424200.0 972680.0 801960.0 False True 1184285.4027577473 967439.9797781365 969646.1281559116 1.0 0.816897664638388 0.8187605165933625 20.175585369484654 -10.039889781759385 5.344635690627453 1.000001345982981 0.8178290906156096 0.9999215756614975 0.000760506126936568 1.2196918888549313e-08 2.191617026748186e-09 0.0007363623328976934 0.0002454522968916704 9.122423251121459e-11 10.039889781759385 -0.18217225536737147 SLFK(ub)EDCDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLFKEDCDR 9 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 131280000.0 49597000.0 47336000.0 34347000.0 True False 65022147.29803124 40273653.31428282 30793101.919688594 1.0 0.6193836252390612 0.47357866818127914 25.95442786473485 -13.99999999999999 0.1329261582982382 2.810087534069717 0.2767788942039939 0.9996325760402864 0.004253879129066452 11.93329004333499 0.11365793154913993 5.629554663822153 0.17523285674067265 1.0000000000000246e-14 13.99999999999999 -2.5333086398657234 SLFK(ub)EDCDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLFKEDCDR 9 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 65431400.0 34029000.0 20155700.0 11246700.0 True False 32948768.021532826 28203976.120586976 8300851.876232189 1.0 0.8559948615424706 0.2519320865292256 24.973721187033536 -6.943783900875036 0.6233685880620401 1.0065986181918356 0.06914075425338032 0.9986186867854473 0.012044663111355132 0.08608203594846157 0.047061748194517486 0.012092883317308572 0.051187707936563534 1.138193494800996e-07 6.943783900875036 -0.9374578639384553 down SLFK(ub)EDCDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLFKEDCDR 9 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 81495800.0 24762900.0 22209900.0 34523000.0 True False 37567129.71048483 18246369.818259265 27699513.918031536 1.0 0.4857003970991901 0.73733378438813 25.162967556325405 -10.134858387517816 5.160733814692951 1.0000133231261608 0.6115170907432246 0.7606477382106285 0.1027289001858645 1.5748071570756136e-05 2.6399949659157023e-06 0.09947023862977848 0.03315560996595239 7.330635277079241e-11 10.134858387517816 -0.3884962323829362 SLFK(ub)EDCDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLFKEDCDR 9 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 129282000.0 49597000.0 45801000.0 33884000.0 True False 67934351.20852835 43777360.37634699 25881297.06288525 1.0 0.6444068368588654 0.38097511203781337 26.01763792625774 -7.820375033998696 0.19213684154911012 1.2445796960294477 1.0556060360815189e-13 0.9999028755099262 0.0024997364007838265 0.12438331480723995 0.027727984551170776 0.061133348086049845 0.0924313436331881 1.512254780289205e-08 7.820375033998696 -1.2445796960293423 down SLFK(ub)EDCDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLFKEDCDR 9 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 87548200.0 34029000.0 17991200.0 35528000.0 True False 28296621.240305673 17894277.834626395 42956740.537088096 1.0 0.6323821378765111 1.5180872717022684 24.754126462467813 -6.793977463330849 1.4802804895923358 0.7955898295242841 1.5285810747223476 0.81396326299974 0.1567082893029719 0.22948893446734012 0.9932619507126065 0.0833065278705051 0.1945017654727536 1.607024643533681e-07 6.793977463330849 0.7329912451980635 SLFK(ub)EDCDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLFKEDCDR 9 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 70156700.0 24762900.0 28975000.0 16418800.0 True False 32056062.19973435 27362515.778927952 13430746.871114587 1.0 0.8535831883666206 0.4189768159117775 24.934093878417855 -6.951689271138169 0.5399786483226626 1.0063994224876733 0.24609113327395354 0.9993272770342734 0.00639956896268127 0.08281439974351652 0.03320915280514221 0.007039005119316594 0.03599144400620364 1.1176626266363865e-07 6.951689271138169 -0.7603082892137198 down SLFK(ub)EDCDRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLFKEDCDRR 10 2 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 320074000.0 132730000.0 119390000.0 67954000.0 True False 174010315.35914862 101577477.37857503 60922771.94079593 1.0 0.5837439991354776 0.3501101174091568 27.374597590899217 -9.38983893994528 0.1564061749136843 1.5594274456342427 4.31360063443434e-11 0.9997719846682096 0.004058704096507446 0.8253593176004979 0.059250710961288124 0.3867098159757458 0.1774979414522892 4.075313846232267e-10 9.38983893994528 -1.5594274455911068 SLFK(ub)EDCDRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLFKEDCDRR 10 2 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 192347000.0 109150000.0 54992000.0 28205000.0 True False 105685092.9956894 76950592.37949157 20817264.368137214 1.0 0.7281120752065777 0.19697446232068216 26.655196656369508 -7.1685631162129315 0.492833388065806 1.0114392054466266 1.1955344790805478e-24 0.9992977531881648 0.008837198178930883 0.08373880540773085 0.03402622233685835 0.010198926209774486 0.04576025955233704 6.783235322696141e-08 7.1685631162129315 -1.0114392054466266 down SLFK(ub)EDCDRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLFKEDCDRR 10 2 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 342628000.0 132730000.0 89468000.0 120430000.0 True False 181803867.89338017 85515007.9288883 91986914.33370526 1.0 0.4703695741998131 0.5059678619579836 27.43780765242211 -10.08402370403069 5.486171627027619 1.0000048297372863 0.4881687180786794 0.9963851262364453 0.014532940121484211 8.585130385071473e-07 1.4336564820261982e-07 0.014071591440112143 0.0046904862550498074 8.24093134330842e-11 10.08402370403069 -0.511836111658607 SLFK(ub)EDCDRR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLFKEDCDRR 10 2 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 253001000.0 109150000.0 51365000.0 92486000.0 True False 90763061.16487026 51088286.549845785 111824394.9930514 1.0 0.5628753139676986 1.2320474161831476 26.435601931803784 -6.7304393127288735 1.721399386974192 0.7370637881243084 1.2316949743212762 0.561316092612405 0.18375196233990318 0.33545898921231737 1.9475686232892604 0.08458013712575 0.2097939117536231 1.860204485582859e-07 6.7304393127288735 0.4946311861969678 SLFK(ub)EDCDRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLFKEDCDRR 10 2 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 315429900.0 150840000.0 429900.0 164160000.0 True False 195265353.50091982 405975.6870875283 134284564.42384142 1.0 0.0020790973913639827 0.6877029745228657 27.54086074945736 -10.462674738240331 8.199662297836795 1.0000257292930153 0.34489103870826104 0.5489989456381514 0.2799047757401412 0.0001316598687040047 8.627580944635177e-06 0.27102721506354926 0.09033887791379078 3.4460792579162456e-11 10.462674738240331 -0.6551346905847542 SLFSNVVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLFSNVVTK 9 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 6815600.0 1077800.0 3510500.0 2227300.0 False True 1413006.2374300458 2986747.083821825 1996840.3617702422 1.0 2.1137536443250777 1.413185808296264 20.430336403495343 -10.154924800924727 4.802625847509055 0.9999457718029162 1.7634697263078658 0.6129303400803096 0.286005621517496 36587553.928187676 77362677.63428763 16949.41698365114 0.09790733269259096 6.999631857241693e-11 10.154924800924727 0.7635239545049496 SLFSNVVTKNK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLFSNVVTKNK 11 1 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 1 11275200.0 2028400.0 7782400.0 1464400.0 True False 1964009.5522900254 10889952.904679848 1080829.7089416815 1.0 5.544755570044054 0.5503179491573447 20.905370515783265 -6.667198646258243 1.9470691002587832 3.9078801811122617 0.5706546874814853 0.2667086886895027 1.9317748452707557 0.4676384515849397 3.4150756218028717 0.7994554955174987 2.1439605648610596 2.1517972777086204e-07 6.667198646258243 -3.3372254936307764 SLFSNVVTKNK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLFSNVVTKNK 11 1 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 1 10649840.0 2028400.0 7789700.0 831740.0 True False 1686704.4733561405 7747735.3399656145 1005652.9884687484 1.0 4.593416014691337 0.5962235853135186 20.68577579121754 -6.669805417385374 1.9377050616081337 3.2940986827484924 0.6123052293510012 0.27817160130577656 1.526486170365271 0.4616694825224188 3.341602444556241 0.6341910154421938 1.6950503123791854 2.1389202031321607e-07 6.669805417385374 -2.681793453397491 SLFSSIGEVESAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLFSSIGEVESAK 13 0 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 0 22100400.0 3393700.0 5880700.0 12826000.0 False True 4449173.564637545 5003322.482789058 11498888.55567958 1.0 1.1245509778615836 2.584499882646486 22.08510594923991 -6.923734798303891 0.7965349530574615 0.9719138492107547 2.841418487072942 0.9951571318093884 0.050062361288172874 0.09602367734701701 0.09458928863359342 0.04401022538993915 0.1369312511369518 1.1919696614787033e-07 6.923734798303891 1.8695046378621871 up SLFSSIGEVESAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLFSSIGEVESAK 13 0 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 0 16434100.0 4810700.0 2642500.0 8980900.0 False True 4657986.961744048 3697664.0304554556 6628532.868775171 1.0 0.7938330572464661 1.4230466772911081 22.1512751706047 -6.818469244519488 1.3787466576412255 0.888704332978173 1.4363078064809216 0.8807636352098813 0.09043998241357674 0.19548329749256696 0.7306310144413729 0.051555404276549026 0.11886299172393974 1.5189055027227162e-07 6.818469244519488 0.5476034735027486 SLFSSIGEVESAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLFSSIGEVESAK 13 0 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 0 19331300.0 3393700.0 6658000.0 9279600.0 False True 4648442.601294077 6363827.5449382765 7087949.599361044 1.0 1.3690235829020787 1.5248009295388167 22.1483160107628 -11.945760522551494 0.14405981535994974 5.3932772206305867e-17 1.7316905076493536 0.9996323540705213 0.004219560579462095 5.31510405107203 0.0981095790021849 1.7687980318703247 0.16044445803861374 1.133024960467576e-12 11.945760522551494 1.7316905076493536 SLFSSIGEVESAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLFSSIGEVESAK 13 0 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 0 10621600.0 4810700.0 2489000.0 3321900.0 False True 4000310.200145132 2475591.262972184 4016493.9312697886 1.0 0.6188498239167476 1.0040456190432605 21.931680446038975 -10.957072797284546 10.991529456850998 1.063620367250335 0.81144772148006 0.24212380767592723 0.1572555248542673 0.09158850489418097 0.00035769674748521935 0.05688143386693628 0.050754002404973644 1.1038935676093024e-11 10.957072797284546 -0.2521726457702751 SLFSSIGEVESAK(ub)LIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLFSSIGEVESAKLIR 16 1 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 1 7378400.0 2919700.0 2903900.0 1554800.0 True False 3827754.9744150233 2470649.439313541 1393924.2106947282 1.0 0.6454565289125169 0.3641623405917602 21.868067051052428 -7.645911940921322 0.21299987112593222 1.192621328381714 4.6979579273196894e-14 0.9998998543461975 0.002603419172294183 0.13180320465170567 0.025160883313227835 0.041546155688290516 0.07763843955464292 2.2598939478244616e-08 7.645911940921322 -1.192621328381667 down SLFSSIGEVESAK(ub)LIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLFSSIGEVESAKLIR 16 1 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 1 19695300.0 7224100.0 5748500.0 6722700.0 True False 6994774.899772418 8043906.028031471 4961823.193323028 1.0 1.14998783281692 0.7093613825206107 22.73784619980821 -6.814844404118481 1.3939835156464722 1.081288518109924 0.7007619148793496 0.8721164796233506 0.06541163257751174 0.2002712287335886 0.7660209353661908 0.036886198022118934 0.08515746038751101 1.5316361068850673e-07 6.814844404118481 -0.3805266032305745 SLFSSIGEVESAK(ub)LIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLFSSIGEVESAKLIR 16 1 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 1 63978300.0 8717300.0 13990000.0 41271000.0 True False 13224781.419995615 11493375.195631096 33113768.760278076 1.0 0.8690786509524713 2.503918039069492 23.65674054179512 -6.8875176105403675 1.0369932706955773 0.9068591653985502 2.6378573679505926 0.9792598569273091 0.10682129062405804 0.12117881022758396 0.23381700542599484 0.07873527780144855 0.19460683557993488 1.2956341587876085e-07 6.8875176105403675 1.7309982025520423 up SLFSSIGEVESAK(ub)LIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLFSSIGEVESAKLIR 16 1 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 1 11553000.0 2919700.0 3629900.0 5003400.0 True False 3999191.9919257276 3469519.0155259017 3821699.968257587 1.0 0.8675550017430463 0.9556180288352015 21.93127711257532 -10.48012211810212 5.572932660386494 1.0001120135342003 0.9115865152905966 0.5733727864188366 0.03595158026344576 5.0098702790452726e-05 4.673545779629147e-06 0.03485400033741329 0.011603322635846977 3.310380246988986e-11 10.48012211810212 -0.08852549824360367 SLFSSIGEVESAK(ub)LIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLFSSIGEVESAKLIR 16 1 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 1 18447100.0 7224100.0 7983500.0 3239500.0 True False 6007159.231893164 7940491.300899315 3916864.47224434 1.0 1.3218379926974 0.6520327364470302 22.518251475242486 -6.776021051251969 1.5511248989088962 1.183171948311808 0.6473504751045722 0.7531551318942604 0.1358923787144765 0.2567996298059782 1.220032958207509 0.0690197910759324 0.1634245312669541 1.6748616896622493e-07 6.776021051251969 -0.5358214732072357 SLFSSIGEVESAK(ub)LIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLFSSIGEVESAKLIR 16 1 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 1 71521300.0 8717300.0 10924000.0 51880000.0 True False 11284716.69367256 10316069.797032239 42438372.33375308 1.0 0.9141629406448946 3.7606945292254124 23.42786686388757 -6.899945690603005 0.961596040542859 0.8814752619225213 4.059172510447827 0.9865397128910924 0.1533880712370986 0.11144577168497212 0.1776388457964602 0.1196470481938124 0.3112216507927964 1.2590828527886982e-07 6.899945690603005 3.177697248525306 up SLFSVLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLFSVLVR 8 0 Q86V87 Q86V87 FAM160B2 Protein FAM160B2 0 3738300.0 1142000.0 1111200.0 1485100.0 False True 1497173.0591437323 945413.2914236748 1331436.0980851194 1.0 0.6314656048943189 0.8893000645139837 20.513809562355803 -10.146716879365103 5.463524078610936 1.0000052189730069 0.7603828347040994 0.5352244474538103 0.10526047736258481 6.6916047414418985e-06 1.0452134473475848e-06 0.101920238883889 0.033972672986567996 7.13317897193613e-11 10.146716879365103 -0.23962238426890747 SLFSVLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLFSVLVR 8 0 Q86V87 Q86V87 FAM160B2 Protein FAM160B2 0 2798110.0 1248600.0 833780.0 715730.0 False True 1208963.876449086 1166712.7021052607 528258.8415602501 1.0 0.9650517478918199 0.4369517169626508 20.20533970717312 -6.920335733423553 0.8222361654658793 1.0115118949639086 0.3511306556703626 0.9942735654081493 0.019492023269329 0.09797478219668772 0.10459483012073431 0.016824255187433256 0.050559275375030265 1.2013353775061524e-07 6.920335733423553 -0.660381239293546 down SLFSVLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLFSVLVR 8 0 Q86V87 Q86V87 FAM160B2 Protein FAM160B2 0 4357200.0 1142000.0 1050600.0 2164600.0 False True 1564228.261389588 1004181.0181303917 1653366.061336363 1.0 0.6419657814124415 1.056985161403227 20.577019623878694 -6.678477186114516 1.9074742545739376 0.7731580955618328 1.0553813936199015 0.3171254642378507 0.15179416594292625 0.44189389332163803 3.1072628400892763 0.06388850467689579 0.16882019978230586 2.0966349155447443e-07 6.678477186114516 0.2822232980580687 SLFSVLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLFSVLVR 8 0 Q86V87 Q86V87 FAM160B2 Protein FAM160B2 0 8599000.0 2593600.0 3404000.0 2601400.0 False True 3357466.3274992467 3214564.4076435156 2127971.892618064 1.0 0.9574375716934832 0.6338028992841899 21.678941500058514 -6.9310541251573206 0.7380890390783256 1.004734108913562 0.5655431763016441 0.9967413578255205 0.009334500552080465 0.09209428149731423 0.07502604295556721 0.008558110138629331 0.02911549828844365 1.1720492865444644e-07 6.9310541251573206 -0.4391909326119179 SLFVLPHTDHLVGYIIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLFVLPHTDHLVGYIIR 17 0 Q7Z392;Q7Z392-4;Q7Z392-3 Q7Z392 TRAPPC11 Trafficking protein particle complex subunit 11 0 5577100.0 1837400.0 1596800.0 2142900.0 False True 1527879.5106214604 1588197.7214600143 2590970.4823498675 1.0 1.0394783819137805 1.6957950311775554 20.543099345497012 -6.919216903150733 0.8304956845272251 0.9851072635807735 1.7997555529607046 0.993961260688945 0.02479728224445723 0.09863396479621449 0.10801088559572776 0.021277526404957385 0.06326864547583558 1.204434249944229e-07 6.919216903150733 0.8146482893799311 SLGELYFLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLGELYFLPR 10 0 Q96GW9 Q96GW9 MARS2 Methionine--tRNA ligase, mitochondrial 0 5873900.0 1368900.0 2066500.0 2438500.0 False True 1794641.1564464562 1758186.2551539077 2186187.4117436954 1.0 0.979686801920484 1.218175234581455 20.775263971272405 -6.886193830702082 1.044669237143008 0.9859921943756197 1.2372183446394238 0.978346907675592 0.01588566106075952 0.12228426106730479 0.2403397149125727 0.011640776841154828 0.028649318191939544 1.299589426631706e-07 6.886193830702082 0.2512261502638041 SLGELYFLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLGELYFLPR 10 0 Q96GW9 Q96GW9 MARS2 Methionine--tRNA ligase, mitochondrial 0 12116600.0 4223600.0 5985000.0 1908000.0 False True 6407509.986520304 4916929.988981561 1530882.9636938912 1.0 0.7673698518340936 0.23892010576877157 22.611332391376664 -7.011008309658938 0.4861866513378342 1.0118762406115123 5.331146896402352e-11 0.9996454207323301 0.005996251685556305 0.07463808052688918 0.025485205141500454 0.007396989159869126 0.04012024911824661 9.749709827397473e-08 7.011008309658938 -1.0118762405582007 down SLGELYFLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLGELYFLPR 10 0 Q96GW9 Q96GW9 MARS2 Methionine--tRNA ligase, mitochondrial 0 8240700.0 1368900.0 3410800.0 3461000.0 False True 1875019.3231315278 3260099.5779927145 2643583.0815324574 1.0 1.7387018564416292 1.409896446889586 20.838474032795297 -10.240886817229562 4.748679818294347 0.9998573250135412 1.574299151667144 0.8026675424923442 0.1342342463502489 0.00020281385806115242 3.24214251890409e-05 0.13000371554230822 0.0433239167163416 5.7426610389635973e-11 10.240886817229562 0.5744418266536029 SLGELYFLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLGELYFLPR 10 0 Q96GW9 Q96GW9 MARS2 Methionine--tRNA ligase, mitochondrial 0 13498700.0 4223600.0 4051700.0 5223400.0 False True 5467533.45960279 3826219.3332694555 4272794.796609974 1.0 0.6998072095104153 0.7814848922607942 22.382458713469113 -9.951339493555109 6.507335765890112 1.0000000388961705 0.7406460508855991 0.9307654882729772 0.03334477435191315 1.8806229097350886e-08 3.0311979812699283e-09 0.032285943747960684 0.010761979645663857 1.1185631464868705e-10 9.951339493555109 -0.2593539880105714 SLGLTIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLGLTIR 7 0 A0A669KBJ1;Q9P202 A0A669KBJ1 DFNB31 Whirlin 0 35759700.0 11853000.0 17108000.0 6798700.0 False True 15539397.784615276 14555553.086461695 6095235.741735437 1.0 0.9366870768230392 0.39224401268432696 23.889427258691786 -6.928777568989786 0.7567610233513657 1.00866579677895 0.2838750385407625 0.996292447499399 0.01661089519440946 0.09327760909283143 0.08082692754549822 0.01502470298304801 0.04959800865406097 1.1782092581263376e-07 6.928777568989786 -0.7247907582381876 down SLGLTIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLGLTIR 7 0 A0A669KBJ1;Q9P202 A0A669KBJ1 DFNB31 Whirlin 0 61233000.0 16064000.0 28467000.0 16702000.0 False True 15554057.112989035 39834021.55344383 12327245.150740227 1.0 2.561005226101352 0.792542104043444 23.890787605554763 -6.673635582278241 1.924071931775119 1.9932124890613245 0.7994922913759271 0.2954758967958053 0.6625233127061994 0.4527931453404448 3.234929278112188 0.27684268723042343 0.7362767169563432 2.1201394040084397e-07 6.673635582278241 -1.1937201976853973 SLGLTIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLGLTIR 7 0 A0A669KBJ1;Q9P202 A0A669KBJ1 DFNB31 Whirlin 0 41459700.0 24257000.0 7540100.0 9662600.0 False True 36799642.42424073 6194510.243929803 7752782.8747319775 1.0 0.1683307183400604 0.21067549476037978 25.1331884121438 -10.465911095736205 6.098625258633816 1.0004482737133316 0.18950310655021999 0.9979569917698558 0.017287182583670194 0.00010542022451193456 9.232228321253303e-06 0.01674683168522511 0.005579414187450089 3.420494561657046e-11 10.465911095736205 -0.8109451671631116 SLGLTIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLGLTIR 7 0 A0A669KBJ1;Q9P202 A0A669KBJ1 DFNB31 Whirlin 0 30852300.0 11853000.0 12169000.0 6830300.0 False True 16235374.415280884 11631333.342498347 5217123.814444136 1.0 0.7164191625633732 0.3213429934534636 23.952637320214677 -7.0160097859284285 0.3407279188792237 1.043944098401258 7.949375438220566e-11 0.9999374980703503 0.0022002135715080405 0.0731204583954759 0.013470649554636251 0.005615404536324511 0.03246815272332071 9.638073059739165e-08 7.0160097859284285 -1.0439440983217643 down SLGLTIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLGLTIR 7 0 A0A669KBJ1;Q9P202 A0A669KBJ1 DFNB31 Whirlin 0 52664300.0 16064000.0 29540000.0 7060300.0 False True 13357927.755863257 29380862.156769074 8536576.086861162 1.0 2.1995074905142227 0.6390644000237359 23.67119288098904 -6.701371170703511 1.8261230992394575 1.7438436617284832 0.6436053571752455 0.42404911138532186 0.5062005273362375 0.39266315283220676 2.546684433127864 0.2210722310860318 0.5675488787857905 1.9889727325971065e-07 6.701371170703511 -1.1002383045532378 SLGLTIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLGLTIR 7 0 A0A669KBJ1;Q9P202 A0A669KBJ1 DFNB31 Whirlin 0 37559500.0 24257000.0 10249000.0 3053500.0 False True 31401164.67695449 9678634.14040494 2497794.3315558014 1.0 0.30822532348642945 0.07954463973716708 24.904314734236248 -9.865056610427194 0.2947361486256369 1.462364743223419 8.67814253284335e-22 0.9987837083972408 0.013646949475786043 1.2919744007945506 0.13215322242864888 0.6023927517168455 0.08213988967273934 1.36440527432499e-10 9.865056610427194 -1.462364743223419 SLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNR 34 0 E9PMG4;Q9BUR4 E9PMG4 WRAP53 Telomerase Cajal body protein 1 0 26923100.0 7574500.0 10523000.0 8825600.0 False True 11491070.270124545 8645088.433425738 7081216.29160211 1.0 0.7523310040059513 0.6162364449212754 23.454009840045163 -13.99999999954294 0.07211856229410331 2.4095414464371605 0.14315480051799953 0.9999170487644551 0.0014468710446830227 12.338376847316956 0.07318790294157293 2.8893897051465984 0.4343228393553813 1.00000000105242e-14 13.99999999954294 -2.266386645919161 SLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLGLYAWDDGSPLALLGGHQGGITHLCFHPDGNR 34 0 E9PMG4;Q9BUR4 E9PMG4 WRAP53 Telomerase Cajal body protein 1 0 18878200.0 7574500.0 4322400.0 6981300.0 False True 9805339.565716762 4081854.640305035 5710775.034187172 1.0 0.41628896306424396 0.5824148155107486 23.225136162137613 -10.771300437441466 10.610454572198442 1.0018746761852393 0.4993518892876202 0.9237199658067804 0.06782059526313747 0.0030125691797724175 6.493336829393267e-05 0.06577490668191993 0.02188900299866708 1.6931660920740393e-11 10.771300437441466 -0.5025227868976191 SLGSTAGTDITVNSVILLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLGSTAGTDITVNSVILLPK 20 0 Q2TAY7;Q2TAY7-2 Q2TAY7 SMU1 WD40 repeat-containing protein SMU1;WD40 repeat-containing protein SMU1, N-terminally processed 0 3086900.0 3086900.0 0.0 0.0 False True 4683052.982618983 0.0 0.0 1.0 0.0 0.0 22.159017929660802 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 SLGTADVHFER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLGTADVHFER 11 0 Q86V81;E9PB61 Q86V81 ALYREF THO complex subunit 4 0 27020600.0 9477500.0 8572600.0 8970500.0 False True 12425094.280240549 7293601.495733086 8042318.711112074 1.0 0.5870057265748073 0.6472642001519183 23.566753463050965 -10.442867674446031 6.023803986166104 1.000168651335562 0.6171349633634177 0.981760551569376 0.024600418823817746 5.574343824601023e-05 5.155647971869203e-06 0.02382961407806907 0.007939751034531081 3.6068852477328406e-11 10.442867674446031 -0.38303368797214443 SLGTADVHFER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLGTADVHFER 11 0 Q86V81;E9PB61 Q86V81 ALYREF THO complex subunit 4 0 19638700.0 7603200.0 2220700.0 9814800.0 False True 7361840.577781262 3107437.09079751 7244009.442311413 1.0 0.4221005681888918 0.9839943375267491 22.811635077517394 -10.916041985450764 10.729256001961213 1.0373147059250327 0.7030474528578204 0.27134706655078067 0.22939217075447643 0.1246790412840398 0.0009756304382691601 0.1352469433169222 0.07403600475687129 1.2132715516792427e-11 10.916041985450764 -0.3342672530672123 SLGTADVHFER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLGTADVHFER 11 0 Q86V81;E9PB61 Q86V81 ALYREF THO complex subunit 4 0 41311600.0 6859200.0 27634000.0 6818400.0 False True 10405907.87468985 22702496.794572506 5470740.251389116 1.0 2.181693040911066 0.5257340654240775 23.310899504265493 -6.7151079103732805 1.776662745272412 1.7226781456079578 0.5289651098029158 0.4893277446303933 0.4975866251426591 0.3649757706392129 2.2486614225992825 0.22260030266219222 0.5621050661651751 1.9270460351426726e-07 6.7151079103732805 -1.193713035805042 SLGTADVHFER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLGTADVHFER 11 0 Q86V81;E9PB61 Q86V81 ALYREF THO complex subunit 4 0 23248900.0 9477500.0 5330700.0 8440700.0 False True 12981587.869807182 5095172.04773243 6447180.501673222 1.0 0.3924922050239228 0.49664036220624397 23.629963524573856 -10.094678105694133 5.45898724880289 1.0000063458727817 0.44456628361557854 0.9743080963639558 0.042518307125477495 3.2838426771076667e-06 5.445815930688274e-07 0.04116864349010592 0.013722724617038166 8.041219077004373e-11 10.094678105694133 -0.5554400622572031 SLGTADVHFER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLGTADVHFER 11 0 Q86V81;E9PB61 Q86V81 ALYREF THO complex subunit 4 0 13372200.0 7603200.0 4012200.0 1756800.0 False True 6322397.678870735 3990585.4822406527 2124138.757474569 1.0 0.6311822958522636 0.3359704443416107 22.59204035295167 -7.69297959233385 0.22931692967889353 1.1739481444014308 2.34524273913166e-13 0.9998458101664416 0.003373079469049723 0.12967617530783102 0.02934941574471756 0.04292648108611349 0.08028739635862335 2.027778003357425e-08 7.69297959233385 -1.1739481444011963 down SLGTADVHFER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLGTADVHFER 11 0 Q86V81;E9PB61 Q86V81 ALYREF THO complex subunit 4 0 22247600.0 6859200.0 8274000.0 7114400.0 False True 8879369.615045799 7813544.626569452 5819652.199908488 1.0 0.8799661423407421 0.6554127660197048 23.082025826357942 -6.961330222431426 0.4162641080362462 1.0103340236299498 0.5166258672297098 0.9998163915973561 0.001935205750500322 0.07922934795668678 0.019400681134797464 0.002898605246465682 0.018712291810815143 1.0931248760265841e-07 6.961330222431426 -0.49370815640024 SLGVHLSFIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLGVHLSFIR 10 0 Q9NP61-2;Q9NP61;B0QYV9;B0QYV8;Q8N6H7;G5E9L0;A0A0D9SF70;E9PQP3;E9PIY6;E9PK28;E9PJT7;E9PMU9;E9PMR9;H0YDX1;E9PNY8;E9PM63;E9PN48 Q9NP61-2;Q8N6H7;E9PN48 ARFGAP3;ARFGAP2 ADP-ribosylation factor GTPase-activating protein 3;ADP-ribosylation factor GTPase-activating protein 2 0 19887700.0 5397700.0 9088900.0 5401100.0 False True 7076436.971401162 7732871.5482547125 4842245.983009585 1.0 1.0927634315837866 0.6842774128532655 22.754591706811123 -6.847011219338828 1.2493637828140978 1.0494042828066905 0.6688597611874723 0.9358514265210929 0.04428476509195981 0.16077516098808498 0.4844204089862883 0.027755902220005246 0.0641205011610424 1.4222920438918223e-07 6.847011219338828 -0.38054452161921826 SLGVHLSFIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLGVHLSFIR 10 0 Q9NP61-2;Q9NP61;B0QYV9;B0QYV8;Q8N6H7;G5E9L0;A0A0D9SF70;E9PQP3;E9PIY6;E9PK28;E9PJT7;E9PMU9;E9PMR9;H0YDX1;E9PNY8;E9PM63;E9PN48 Q9NP61-2;Q8N6H7;E9PN48 ARFGAP3;ARFGAP2 ADP-ribosylation factor GTPase-activating protein 3;ADP-ribosylation factor GTPase-activating protein 2 0 23054100.0 13852000.0 6676800.0 2525300.0 False True 13412275.842201449 9342881.059052018 1863848.1726238923 1.0 0.6965917767404423 0.13896583954524203 23.67705072380122 -7.317151155720984 0.5345411337075943 1.007254096405732 2.541380083171169e-19 0.9978888392240162 0.016384194050746856 0.10161596479206526 0.05643731595485352 0.01697350463556744 0.05875068123618836 4.8178008540727595e-08 7.317151155720984 -1.007254096405732 down SLGVHLSFIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLGVHLSFIR 10 0 Q9NP61-2;Q9NP61;B0QYV9;B0QYV8;Q8N6H7;G5E9L0;A0A0D9SF70;E9PQP3;E9PIY6;E9PK28;E9PJT7;E9PMU9;E9PMR9;H0YDX1;E9PNY8;E9PM63;E9PN48 Q9NP61-2;Q8N6H7;E9PN48 ARFGAP3;ARFGAP2 ADP-ribosylation factor GTPase-activating protein 3;ADP-ribosylation factor GTPase-activating protein 2 0 296461000.0 78671000.0 102860000.0 114930000.0 False True 119349658.6204988 84503829.35115196 92214035.12439154 1.0 0.7080357860080051 0.7726376111188423 26.83061919893947 -10.117430652007402 5.031289199508494 1.0000090554682117 0.7403366985646752 0.9556368282153646 0.026373584665529047 2.7862089981984144e-06 4.887582214647893e-07 0.02553703924960345 0.00851203784865327 7.630787295812196e-11 10.117430652007402 -0.2596723569035365 SLGVHLSFIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLGVHLSFIR 10 0 Q9NP61-2;Q9NP61;B0QYV9;B0QYV8;Q8N6H7;G5E9L0;A0A0D9SF70;E9PQP3;E9PIY6;E9PK28;E9PJT7;E9PMU9;E9PMR9;H0YDX1;E9PNY8;E9PM63;E9PN48 Q9NP61-2;Q8N6H7;E9PN48 ARFGAP3;ARFGAP2 ADP-ribosylation factor GTPase-activating protein 3;ADP-ribosylation factor GTPase-activating protein 2 0 39452700.0 5397700.0 15831000.0 18224000.0 False True 7393375.557357778 15131534.073883744 13919866.535061393 1.0 2.0466340383351778 1.8827484722061154 22.817801768334014 -10.182492272925835 4.7561214958402935 0.9998761918102462 1.9646912552296665 0.9788131787355254 0.06690600222276512 8.855163012956002e-05 1.5220688891956477e-05 0.06478971455854614 0.02159381936147445 6.569128043263637e-11 10.182492272925835 0.9648150634194202 SLGVHLSFIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLGVHLSFIR 10 0 Q9NP61-2;Q9NP61;B0QYV9;B0QYV8;Q8N6H7;G5E9L0;A0A0D9SF70;E9PQP3;E9PIY6;E9PK28;E9PJT7;E9PMU9;E9PMR9;H0YDX1;E9PNY8;E9PM63;E9PN48 Q9NP61-2;Q8N6H7;E9PN48 ARFGAP3;ARFGAP2 ADP-ribosylation factor GTPase-activating protein 3;ADP-ribosylation factor GTPase-activating protein 2 0 30704000.0 13852000.0 7290600.0 9561400.0 False True 11518551.747648021 7251324.090729202 11560644.533081355 1.0 0.6295343589709403 1.0036543470355923 23.457455999235496 -10.964242405629 10.79354724499767 1.0754156396791932 0.8165943530032663 0.2426748198169506 0.152733845555755 0.08707945280201636 0.0002884824868679032 0.04645944480153242 0.04929463668663791 1.085819393941013e-11 10.964242405629 -0.25882128667592685 SLGVHLSFIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLGVHLSFIR 10 0 Q9NP61-2;Q9NP61;B0QYV9;B0QYV8;Q8N6H7;G5E9L0;A0A0D9SF70;E9PQP3;E9PIY6;E9PK28;E9PJT7;E9PMU9;E9PMR9;H0YDX1;E9PNY8;E9PM63;E9PN48 Q9NP61-2;Q8N6H7;E9PN48 ARFGAP3;ARFGAP2 ADP-ribosylation factor GTPase-activating protein 3;ADP-ribosylation factor GTPase-activating protein 2 0 286343000.0 78671000.0 125860000.0 81812000.0 False True 101841160.33725044 118855780.36016834 66923055.46200857 1.0 1.1670701705142932 0.6571317062805512 26.60174552103192 -6.8184472663324724 1.378561156555043 1.0901935470093518 0.6463638774595152 0.8807805251668491 0.07329126959421735 0.19550562553386802 0.7304795914730309 0.04178280128238344 0.09634563655288729 1.5189823713805005e-07 6.8184472663324724 -0.4438296695498366 SLGVTQLAVAVNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLGVTQLAVAVNK 13 0 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;E9PHZ9;H0YES5 Q9Y450 HBS1L HBS1-like protein 0 8081400.0 2659400.0 2976900.0 2445100.0 False True 3486499.1536662336 2532758.1238653148 2192104.5070553673 1.0 0.7264473651748887 0.6287408688312046 21.73334770074046 -13.999999999999998 0.14336562700571703 2.311119034262774 0.5125901334229355 0.9995898624740617 0.003182185617196336 11.938959311832766 0.11886487778509598 4.371556992923303 0.10409002674815875 1.0000000000000041e-14 13.999999999999998 -1.7985289008398386 SLGVTQLAVAVNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLGVTQLAVAVNK 13 0 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;E9PHZ9;H0YES5 Q9Y450 HBS1L HBS1-like protein 0 13208400.0 3850300.0 5907700.0 3450400.0 False True 5841186.594634707 4853424.777929222 2768426.927635959 1.0 0.8308970616325163 0.4739494078444329 22.477830041221218 -6.95897654436677 0.44962834491353865 1.0115546429700062 0.27915017405549747 0.9997303280229495 0.0036008741202176527 0.08006881199503443 0.022497880432114314 0.004768336103820386 0.0295270841242538 1.0990651967927624e-07 6.95897654436677 -0.7324044689145087 down SLGVTQLAVAVNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLGVTQLAVAVNK 13 0 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;E9PHZ9;H0YES5 Q9Y450 HBS1L HBS1-like protein 0 7730900.0 2659400.0 2021900.0 3049600.0 False True 3642652.0475827204 1932565.772470816 2329347.2884834995 1.0 0.5305381209147536 0.6394646697120754 21.79655776226335 -9.840991415120833 6.444040607066454 1.0000000141041927 0.585001395313373 0.9508689386499285 0.04446907733286719 9.02973123505305e-09 1.6428184724628493e-09 0.0430570005867448 0.014352332994249501 1.4421438586989615e-10 9.840991415120833 -0.4149986187908197 SLGYAYVNFQQPADAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLGYAYVNFQQPADAER 17 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YBN4;E5RGH3;E5RJB9;E5RH24;E5RHG7;B1ANR0;Q13310-2;Q13310;Q13310-3;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 160515000.0 36051000.0 62251000.0 62213000.0 False True 47263210.118380606 52963393.45249746 55775795.54923541 1.0 1.1206050820466817 1.180110183153731 25.494214284733378 -13.999999999982947 0.09233644925526768 0.3884288974541924 1.3233740952468036 0.9998313375611791 0.00097305697183892 12.143175449433212 0.0888545820851165 1.446485192749761 0.12846023813444235 1.000000000039266e-14 13.999999999982947 0.9349451977926112 SLGYAYVNFQQPADAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLGYAYVNFQQPADAER 17 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YBN4;E5RGH3;E5RJB9;E5RH24;E5RHG7;B1ANR0;Q13310-2;Q13310;Q13310-3;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 177755000.0 55457000.0 35879000.0 86419000.0 False True 53696547.89062709 50205671.80651323 63783271.3855718 1.0 0.9349888173216586 1.1878467777014279 25.678326005659457 -6.838480871380717 1.2894485132069633 0.965406024047352 1.1959156741615806 0.9218090836461793 0.02997934679186592 0.17057948145308058 0.5515907052135649 0.018235412231679668 0.04199492609572825 1.4505046607726954e-07 6.838480871380717 0.23050965011422864 SLGYAYVNFQQPADAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLGYAYVNFQQPADAER 17 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YBN4;E5RGH3;E5RJB9;E5RH24;E5RHG7;B1ANR0;Q13310-2;Q13310;Q13310-3;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 388042000.0 83132000.0 192880000.0 112030000.0 False True 126117321.763284 158459057.0216816 89887221.3955067 1.0 1.256441659291667 0.7127270079856325 26.910191197380144 -6.77844952101136 1.5419089358530857 1.1454958421876964 0.7086272476426679 0.7618675961358303 0.1083770376926811 0.2529902051066724 1.1879317528113493 0.05536608935383872 0.1308112228499075 1.6655224038126956e-07 6.77844952101136 -0.43686859454502847 SLGYAYVNFQQPADAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLGYAYVNFQQPADAER 17 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YBN4;E5RGH3;E5RJB9;E5RH24;E5RHG7;B1ANR0;Q13310-2;Q13310;Q13310-3;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 116133000.0 36051000.0 43984000.0 36098000.0 False True 49380028.94164272 42040641.44436248 27572395.861646544 1.0 0.8513693156001605 0.5583713993815512 25.55742434625627 -6.960326483896481 0.43080901530154836 1.0115389519821787 0.38695077596884314 0.9997821131891751 0.0027082976793818075 0.07958472083695216 0.020702011988241127 0.0038236201171048395 0.02432335687817081 1.0956542207886734e-07 6.960326483896481 -0.6245881760133356 SLGYAYVNFQQPADAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLGYAYVNFQQPADAER 17 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YBN4;E5RGH3;E5RJB9;E5RH24;E5RHG7;B1ANR0;Q13310-2;Q13310;Q13310-3;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 106247000.0 55457000.0 35625000.0 15165000.0 False True 46114952.66166019 35433081.05399117 18335931.384962324 1.0 0.768364250831165 0.39761357925466884 25.458731281093733 -6.964156215142157 0.37224927619829307 1.027793803782038 0.1252330030207367 0.9998946814940082 0.002546110478876532 0.0782484748963597 0.015876687179001425 0.004870706371663897 0.03145007783696716 1.0860349080527785e-07 6.964156215142157 -0.9025608007613013 down SLGYAYVNFQQPADAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLGYAYVNFQQPADAER 17 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YBN4;E5RGH3;E5RJB9;E5RH24;E5RHG7;B1ANR0;Q13310-2;Q13310;Q13310-3;B1ANR1 P11940;B1ANR0 PABPC1;PABPC4 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 308826000.0 83132000.0 135710000.0 89984000.0 False True 107616012.77670693 128157619.20132229 73607835.31380948 1.0 1.190878716787596 0.6839858996313011 26.681317519472593 -6.804691829237315 1.436696193635462 1.1046974881202192 0.6761519158509862 0.845525537837694 0.0821553579397676 0.2141263829819291 0.872018598349634 0.04497642705537629 0.10431352469178008 1.5678632146029116e-07 6.804691829237315 -0.42854557226923295 SLGYLCGLVSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLGYLCGLVSEK 12 0 P48553 P48553 TRAPPC10 Trafficking protein particle complex subunit 10 0 38242000.0 12004000.0 14159000.0 12079000.0 False True 15737360.246901343 12046532.391349724 10829180.949949604 1.0 0.7654735103189663 0.6881192766799533 23.907690230591246 -13.999999999999998 0.15503111306612075 2.143718324972131 0.6077474709487318 0.9995503235345227 0.0028119520840495602 11.980231375931666 0.12424086728437214 4.122763288170609 0.07282220704860749 1.0000000000000041e-14 13.999999999999998 -1.5359708540233994 SLGYLCGLVSEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLGYLCGLVSEK 12 0 P48553 P48553 TRAPPC10 Trafficking protein particle complex subunit 10 0 79002000.0 34687000.0 29284000.0 15031000.0 False True 52622714.95937829 24058041.403063677 12060116.26167867 1.0 0.4571797829442115 0.22918080663432866 25.649182347481368 -10.80725020064909 0.17669922553390693 1.9238717042029843 6.146096588232789e-13 0.9995123107318782 0.00714000890277772 2.783776121522188 0.09684638076683534 1.2386025567083279 0.1660743588463754 1.558654290468047e-11 10.80725020064909 -1.9238717042023696 SLGYLCGLVSEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLGYLCGLVSEK 12 0 P48553 P48553 TRAPPC10 Trafficking protein particle complex subunit 10 0 37294700.0 12004000.0 15321000.0 9969700.0 False True 16442203.195902437 14644067.560228212 7615062.192416685 1.0 0.8906390090032253 0.46314122880529995 23.970900292114138 -6.9454035112427555 0.6072172897552942 1.0047488805988976 0.32687478839711887 0.9987893847520433 0.008059803971569782 0.08538571208903807 0.04401807788618892 0.00821433288542218 0.03601279922895104 1.1339567453437657e-07 6.9454035112427555 -0.6778740922017787 down SLGYLCGLVSEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLGYLCGLVSEK 12 0 P48553 P48553 TRAPPC10 Trafficking protein particle complex subunit 10 0 70546000.0 34687000.0 17605000.0 18254000.0 False True 44903005.28299135 16625266.273961224 14931959.301856754 1.0 0.3702484091918598 0.3325380830915738 25.420308669573817 -13.806328212544653 0.4021138505466945 9.999998719591009 0.3304026204110072 0.999837437662892 0.0039033233123179014 23.004102938562994 0.20893584723757197 179.70231291345718 0.0095966742511969 1.5619667599170002e-14 13.806328212544653 -9.669596099180001 SLGYLCGLVSEKGPNSEDLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLGYLCGLVSEKGPNSEDLNR 21 1 P48553 P48553 TRAPPC10 Trafficking protein particle complex subunit 10 0 27578800.0 8443900.0 10450000.0 8684900.0 False True 10930795.00415287 9868448.313711725 7104337.314599297 1.0 0.9028115804900253 0.6499378418404325 23.38189499722855 -6.954600004484363 0.5058306154964348 1.0048182038778453 0.5369158179565228 0.9995145712730296 0.0032508427035318355 0.08168953175136633 0.028712409426901172 0.0037718594605969193 0.02086506814952583 1.1101968621599983e-07 6.954600004484363 -0.4679023859213225 SLHDAIMIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLHDAIMIVR 10 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 19081100.0 6262300.0 6724200.0 6094600.0 False True 8209935.944199467 5720975.570726316 5463989.255531314 1.0 0.6968355916063309 0.665533725557477 22.96893953513404 -13.999999999999998 0.3208395302210191 4.124022744853574 0.6593774018652033 0.9996955244228826 0.0026319183597491623 18.078769567704047 0.1806773979025707 37.92781884012849 0.010387405304029285 1.0000000000000041e-14 13.999999999999998 -3.46464534298837 SLHDAIMIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLHDAIMIVR 10 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 17517300.0 9202600.0 3661600.0 4653100.0 False True 8910468.500248555 5123695.974991743 3434313.519992178 1.0 0.5750198179645458 0.38542457334273483 23.08706985799796 -13.999999999999998 0.10923355976522882 3.0533861624649927 0.033749954128841346 0.9997469567400414 0.004087549480087426 12.017186802741008 0.10016557760701772 5.449999195104468 0.3124223196763301 1.0000000000000041e-14 13.999999999999998 -3.019636208336151 SLHDAIMIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLHDAIMIVR 10 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 21356800.0 6262300.0 10401700.0 4692800.0 False True 8577641.542294232 9942118.500177905 3584457.2912497846 1.0 1.1590736744075598 0.41788378233990203 23.032149596656932 -6.850550349110699 1.2323446489050989 1.0849326505844687 0.38792354701485227 0.9411135656797881 0.07731199358330025 0.15685293412717813 0.45810257778378355 0.04908214106584882 0.11362568147400598 1.410748674493438e-07 6.850550349110699 -0.6970091035696164 down SLHDAIMIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLHDAIMIVR 10 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 15388800.0 9202600.0 3768800.0 2417400.0 False True 7652369.644304478 3748496.7263517757 2922867.16320527 1.0 0.4898478380669594 0.38195582532800254 22.867475133432237 -13.999999999999998 0.21835511542358987 4.05646513226579 0.3233266165708624 0.9994962988850424 0.006049398713891616 12.955417800422648 0.1480461439066828 17.059594279357107 0.06036466541220421 1.0000000000000041e-14 13.999999999999998 -3.733138515694927 SLHDAIMIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLHDAIMIVR 10 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 6651900.0 2410800.0 0.0 4241100.0 False True 3120828.1239725417 0.0 3469263.3173608305 1.0 0.0 1.111648312418039 21.57349747399542 -10.676995995695878 4.3059997787118975 1.018059246002549 0.5558241562155476 0.1755091033366838 0.4538285231422633 0.07932875705760171 0.005950647427870703 0.4430379023779244 0.14647252601357985 2.1037978372211212e-11 10.676995995695878 -0.46223508978700145 SLHDALCVIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLHDALCVIR 10 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 42568900.0 4851700.0 22231200.0 15486000.0 False True 6360625.683929634 18914391.616538867 13883657.27220129 1.0 2.973668402516879 2.1827502453538314 22.600737257271522 -10.476537329436324 5.980946065228906 0.9988322158909845 2.5782093239353543 0.8414938578782745 0.322890985558644 0.005030351242970347 0.00044026433569784197 0.3127876766273503 0.10421261747576048 3.337818139829429e-11 10.476537329436324 1.57937710804437 SLHDALCVIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLHDALCVIR 10 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 44476000.0 11119000.0 33357000.0 0.0 False True 16868335.907784667 27404182.73056941 0.0 1.0 1.6245931359430954 0.0 24.007814320350157 -6.817580791033364 1.4831710592591694 1.3425620550773936 1.1505746814468474e-18 0.8387640764853453 0.2686772464499746 0.20849925404452824 0.9181493207020142 0.1445433196695856 0.3183810897766577 1.522015968607705e-07 6.817580791033364 -1.3425620550773936 SLHDALCVIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLHDALCVIR 10 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 47686000.0 4851700.0 16502300.0 26332000.0 False True 6645504.602262574 15773173.820191493 20112923.924563058 1.0 2.3735103297981692 3.0265457821991837 22.663947318794413 -9.293812554021205 0.23274884025410544 2.8013929763528213e-17 3.5147117060164765 0.9992568619679367 0.02302378488558724 0.7155959929211639 0.0871957335781548 0.8491269283592848 0.3070190080286273 5.08378816757082e-10 9.293812554021205 3.5147117060164765 SLHDALCVIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLHDALCVIR 10 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 7812230.0 5050200.0 515030.0 2247000.0 False True 4199465.061794112 512255.4311645488 2716837.3110458544 1.0 0.12198111512462517 0.6469484258276353 22.001774134870665 -9.92828106129398 5.915691690079171 1.0000002813806128 0.38446477075502783 0.6470265399408764 0.21431700714489968 7.952882879523307e-07 1.4426678035148707e-07 0.20751164572379732 0.06917051662329046 1.1795570175638478e-10 9.92828106129398 -0.615535510625585 SLHDALCVIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLHDALCVIR 10 0 P48643;E7ENZ3;B7ZAR1;E9PCA1;P48643-2 P48643 CCT5 T-complex protein 1 subunit epsilon 0 24980400.0 11119000.0 8085400.0 5776000.0 False True 14393764.688257284 7635440.382362183 4724827.266764799 1.0 0.5304686124674057 0.3282551416600138 23.778940642442606 -13.625237139817633 0.11952532086470063 3.0587198159268483 3.341437443438583e-20 0.9997093997407923 0.004796745166611031 10.502886414078885 0.10247972506384306 5.259600618665225 0.28387214375459907 2.3700792070001004e-14 13.625237139817633 -3.0587198159268483 SLHDALCVLAQTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLHDALCVLAQTVK 14 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 119494200.0 23492600.0 44773000.0 51228600.0 False True 30799026.102662046 38093042.9237871 45927955.89143037 1.0 1.2368262164138566 1.4912145513413064 24.87638139633061 -6.970214242246788 0.2530211786161288 0.9222109959003527 1.813309217846551 0.9999840037212306 0.0008022067932678094 0.07623329139715687 0.008781275985495201 0.005559618939491215 0.024262183706521237 1.0709908433323617e-07 6.970214242246788 0.8910982219461984 SLHDALCVLAQTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLHDALCVLAQTVK 14 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 130063500.0 81576000.0 31926500.0 16561000.0 False True 78986414.53244476 44674917.94449808 12223177.28064956 1.0 0.5656025559452029 0.15475037515000406 26.23510119886682 -7.782320952668113 0.39057333320531523 1.0534222935775377 5.246619217316323e-25 0.998225600904304 0.014537547252149887 0.11490235827374083 0.06792292278856982 0.033339108116551636 0.07865167447046344 1.6507414150509956e-08 7.782320952668113 -1.0534222935775377 down SLHDALCVLAQTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLHDALCVLAQTVK 14 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 132548200.0 26650000.0 62162000.0 43736200.0 False True 40429998.3759746 51068705.426077195 35091720.899742566 1.0 1.2631389432957436 0.8679624612746882 25.268922809869785 -6.72719903105044 1.7332454965891118 1.1588475935387907 0.8683074606356381 0.5462899097222409 0.11064415939109874 0.3415299485979777 2.008674501068482 0.05061281715289612 0.12600197624872259 1.8741354213346615e-07 6.72719903105044 -0.2905401329031526 SLHDALCVLAQTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLHDALCVLAQTVK 14 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 190669100.0 23492600.0 63226500.0 103950000.0 False True 32178449.083643645 60432944.16792425 79399150.91745125 1.0 1.8780564598013023 2.4674635720032247 24.939591457853503 -8.202374263614209 0.14908100911884126 2.1673943739065608e-14 3.6176400054599065 0.9999304278356821 0.005029117647569222 0.08720435036858959 0.030496472594810392 0.3219562795131682 0.3415598614865417 6.275173477110184e-09 8.202374263614209 3.6176400054598847 SLHDALCVLAQTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLHDALCVLAQTVK 14 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 119392300.0 81576000.0 6111200.0 31705100.0 False True 67834058.42955057 6078277.752621773 38334489.822180614 1.0 0.08960510241229928 0.5651215732874527 26.015506474301095 -10.783345408204658 6.677710201946685 1.0240449543525079 0.3273633378498765 0.7273640346434797 0.1941287863221907 0.06331826375975945 0.0020543236006565885 0.17126210697417477 0.0626547963704419 1.6468520767284824e-11 10.783345408204658 -0.6966816165026314 SLHDALCVLAQTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLHDALCVLAQTVK 14 0 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 0 115150700.0 26650000.0 48756600.0 39744100.0 False True 34498950.35003659 46043252.34950409 32511081.608903512 1.0 1.334627630183979 0.9423788630968892 25.040049131962235 -6.680830815752784 1.899607645640682 1.2115727829437617 0.9438860495593492 0.3276674871328661 0.141798612329075 0.43665938969208423 3.047340675473635 0.059890636812968044 0.15775074682114185 2.0853030779015204e-07 6.680830815752784 -0.2676867333844125 SLHDALCVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLHDALCVVK 10 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 29323600.0 4333600.0 13562000.0 11428000.0 False True 5681391.566642096 11538602.464261953 10245540.185116654 1.0 2.030946525849419 1.8033504758363508 22.43781290757665 -10.012340214890488 5.186457397110179 0.9999930835652552 1.9171485008468092 0.9558528740542469 0.09291569834785439 7.4328038104081795e-06 1.4154483195153087e-06 0.08996591577553083 0.029988412689902866 9.719854975479344e-11 10.012340214890488 0.917155417281554 SLHDALCVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLHDALCVVK 10 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 49147100.0 6118500.0 39283000.0 3745600.0 False True 9282211.822266424 32272641.730520125 3005280.5182452 1.0 3.476826681880242 0.32376771568992324 23.14603718984956 -6.697206193611001 1.840546806109934 2.542213089533756 0.3335494620222789 0.4043732843737906 1.0460474847076386 0.4014099743006102 2.641622065335609 0.45371514667705337 1.1710006176804535 2.0081391652718378e-07 6.697206193611001 -2.208663627511477 SLHDALCVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLHDALCVVK 10 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 30188600.0 4333600.0 14221000.0 11634000.0 False True 5935849.031136527 13592669.197441753 8886288.809751127 1.0 2.289928387016135 1.4970543831452001 22.50102296909954 -10.104929323304862 5.3095134451458375 0.9999841984197061 1.893491385081362 0.6286960260344556 0.3236894566359789 6.054723246410355e-05 1.0207106500184511e-05 0.31341650030915774 0.10447032290748862 7.853634335528453e-11 10.104929323304862 0.8935071866616559 SLHDALCVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLHDALCVVK 10 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 15175100.0 6118500.0 5195100.0 3861500.0 False True 7920518.863665985 4905988.118140078 3158746.62233592 1.0 0.6194023652472381 0.39880551725293223 22.91716351194201 -9.398519799362003 0.1390887705062579 1.5983038272632872 3.851616109094519e-12 0.9998455987082742 0.003085540784910461 0.840394176817638 0.052798008388489054 0.3917484913678316 0.19402400681489995 3.994663493358121e-10 9.398519799362003 -1.5983038272594356 SLHDALCVVK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLHDALCVVKR 11 1 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 1 4110200.0 1584900.0 1226900.0 1298400.0 True False 2077819.2481934302 1043851.3024187435 1164054.0231322583 1.0 0.5023783003869682 0.5602287225630191 20.986638727379116 -10.115406899350551 5.419714938345007 1.0000075274738383 0.5313035114748069 0.9887031625840496 0.023617335956641585 2.148176924433322e-06 3.505879044200233e-07 0.022867754335642726 0.0076224624033932546 7.666428694418228e-11 10.115406899350551 -0.46870401599903133 SLHNK(ub)LLNAAQER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLHNKLLNAAQER 13 1 Q13426-3;Q13426-2;Q13426 Q13426-3 XRCC4 DNA repair protein XRCC4 1 13272300.0 6025400.0 5689600.0 1557300.0 True False 7899357.7500566095 4840733.857887101 1396165.5346764217 1.0 0.6128009404122013 0.17674418336939055 22.913303930401977 -7.568795877990587 0.40417768708129215 1.0390505747220418 7.398828414642755e-13 0.9986448961112553 0.012379417694661658 0.12064285002832414 0.05440560646162641 0.022249928653079686 0.07018987785599538 2.6990076903812176e-08 7.568795877990587 -1.039050574721302 down SLHSATTIGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLHSATTIGNK 11 0 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 4415800.0 1008000.0 1914100.0 1493700.0 False True 1321497.7614858851 1628523.7411033628 1339146.2525821428 1.0 1.2323318196712336 1.0133549156196935 20.333742550492875 -10.779282003135599 3.01463033545858 0.9734720563568845 1.1228433675156586 0.29558103251201606 0.08939694731560904 8972965.686387302 11045325.770830126 1504142.7238871085 0.030602951418909164 1.6623328868964903e-11 10.779282003135599 0.1493713111587741 SLHSATTIGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLHSATTIGNK 11 0 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 3000310.0 949580.0 709630.0 1341100.0 False True 919436.1026738124 992988.9596715621 989825.6778623948 1.0 1.079997790802265 1.076557332242972 19.810389790717554 -9.96432043652563 4.665919699784502 0.9999988485645195 1.0782775615289968 0.9985532352332231 0.0014045613470808653 1.6823721735273716e-08 3.7330847888205274e-09 0.0013599806688693356 0.0004533202224096501 1.0856243192779314e-10 9.96432043652563 0.0782787129644773 SLHSATTIGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLHSATTIGNK 11 0 A6NEM2;P51610-2;P51610;P51610-4;P51610-3 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 3742600.0 1008000.0 1198200.0 1536400.0 False True 1380684.840175747 1145259.562082465 1173533.9631512472 1.0 0.8294865915502377 0.8499651252793277 20.396952612015767 -9.998372557341463 5.528698804708552 1.0000004646939207 0.8397258584577035 0.9879038560180103 0.00836032638669284 4.7883213047217763e-08 8.672527852358578e-09 0.008094874676755345 0.002698283738625044 1.003754355206837e-10 9.998372557341463 -0.16027460623621714 SLIANLAAANCYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLIANLAAANCYK 13 0 P55263;A0A5K1VW54;P55263-3;P55263-4;P55263-2;A0A5F9ZHJ1;A0A5F9ZH31;A0A5K1VW94;A0A5F9ZH72;A0A5F9ZGZ8 P55263 ADK Adenosine kinase 0 14178300.0 3277300.0 5200300.0 5700700.0 False True 4296572.037418343 4424435.510610631 5110846.248975715 1.0 1.0297594156641015 1.1895171789198349 22.034754653105228 -6.938232421673172 0.6758025683018208 0.9981401498019769 1.2304479322537554 0.9979231689775085 0.0037923613601430345 0.08858221101087317 0.05835058295176088 0.0036439116864620228 0.013860512639384658 1.1528361286062911e-07 6.938232421673172 0.23230778245177852 SLIANLAAANCYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLIANLAAANCYK 13 0 P55263;A0A5K1VW54;P55263-3;P55263-4;P55263-2;A0A5F9ZHJ1;A0A5F9ZH31;A0A5K1VW94;A0A5F9ZH72;A0A5F9ZGZ8 P55263 ADK Adenosine kinase 0 13645100.0 3277300.0 4487100.0 5880700.0 False True 4489006.375702356 4288845.085144573 4491799.776818235 1.0 0.9554107805145486 1.0006222760410854 22.09796471462812 -9.954124507840476 4.440759812062443 1.00000048628213 0.9780165283403118 0.23967921160841033 0.018457515776871162 25324920.84709857 3.568396834815615 129.07090245198287 0.006318498588762247 1.1114130507095756e-10 9.954124507840476 -0.021983957941818066 SLIDNFALNPDILCSAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLIDNFALNPDILCSAKR 18 1 Q5UIP0-2;Q5UIP0;H7BZN3 Q5UIP0-2 RIF1 Telomere-associated protein RIF1 1 5350600.0 1855200.0 1770500.0 1724900.0 True False 2432185.1657823552 1506348.3013549466 1546423.894409146 1.0 0.6193394822677504 0.6358166788307466 21.2138216367516 -10.135259528719146 7.86424676881358 1.0000000589525706 0.6275780805567257 0.9985340450070092 0.006726787328480228 6.952089240872759e-09 7.651527551699526e-10 0.006513184891757384 0.0021710612747235848 7.323867375774858e-11 10.135259528719146 -0.3724219783958449 SLIDNFALNPDILCSAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLIDNFALNPDILCSAKR 18 1 Q5UIP0-2;Q5UIP0;H7BZN3 Q5UIP0-2 RIF1 Telomere-associated protein RIF1 1 35592100.0 3137800.0 9171300.0 23283000.0 True False 4760272.003907436 7534609.859306047 18681104.84469859 1.0 1.5828107833168599 3.9243776047596306 22.18261258140291 -6.944773067343175 0.6135528210212365 0.9742188656228221 4.6556569389621 0.99872460672633 0.04513344719459037 0.08565500274949676 0.04518944362123005 0.045724106439315786 0.1976969309865273 1.1356040498415299e-07 6.944773067343175 3.6814380733392778 SLIEK(ub)DVNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLIEKDVNR 9 1 Q8TC07-2;Q8TC07-3;Q8TC07 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 2671840.0 783350.0 977140.0 911350.0 True False 1026979.4359721898 831354.5208618874 817052.2442864942 1.0 0.8095142821188877 0.7955877359053757 19.969975863036787 -13.999999999999998 0.3712162310329479 3.673688224256053 0.7941714189768148 0.9997929721541595 0.0013417379900827887 22.962558679663537 0.1978719508768316 48.88158923723691 0.0038774541373569997 1.0000000000000041e-14 13.999999999999998 -2.8795168052792386 SLIEK(ub)DVNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLIEKDVNR 9 1 Q8TC07-2;Q8TC07-3;Q8TC07 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 4873100.0 926740.0 929460.0 3016900.0 True False 897321.1459718283 1300598.2250698681 2226683.384940015 1.0 1.4494233540671524 2.4814787826363367 19.77526488408757 -6.9572555995177305 0.47253083594257794 0.9734003118332833 2.999991466544493 0.9996544641798567 0.011528755640014468 0.0806965180795177 0.02486759814276393 0.01433858673968158 0.08516671603440623 1.1034290170466199e-07 6.9572555995177305 2.0265911547112094 up SLIEK(ub)DVNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLIEKDVNR 9 1 Q8TC07-2;Q8TC07-3;Q8TC07 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 23720700.0 2762500.0 5429200.0 15529000.0 True False 4190914.4658022393 4460316.841466783 12459686.343397511 1.0 1.064282480079911 2.9730232971987975 21.99883364650204 -6.914055375382244 0.8676520461951466 0.9482085828612098 3.2423620358247227 0.9923642934188297 0.07998270340407075 0.1017972398378561 0.12466916093971715 0.06682533787576131 0.19008996889907223 1.2188341797000933e-07 6.914055375382244 2.294153452963513 up SLIEK(ub)DVNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLIEKDVNR 9 1 Q8TC07-2;Q8TC07-3;Q8TC07 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 4045940.0 926740.0 1655900.0 1463300.0 True False 770625.3715431218 1646979.3380295828 1769269.2644652426 1.0 2.137198434995237 2.295887638532337 19.555670159521846 -10.694484680963015 0.38518288519883437 1.3446854832815156e-22 2.3132825467710467 0.9993450653167965 0.014769771268648339 2.273051490241253 0.18570532812451224 2.179055577312315 0.04219687946457104 2.0207627098786297e-11 10.694484680963015 2.3132825467710467 SLIEK(ub)DVNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLIEKDVNR 9 1 Q8TC07-2;Q8TC07-3;Q8TC07 Q8TC07-2 TBC1D15 TBC1 domain family member 15 1 16062100.0 2762500.0 6720200.0 6579400.0 True False 3576110.7070159824 6346214.962469428 5382016.710344931 1.0 1.7746136745763406 1.504991637922712 21.76995996859449 -10.254892532639513 5.0354597631420885 0.9998867371807135 1.6398026562498589 0.882462555660243 0.11007273553638404 0.00013998583220009458 2.0713994911161295e-05 0.10659614735060685 0.03552582263349358 5.560418343244963e-11 10.254892532639513 0.6399159190691454 SLIGK(ub)K(ub)GQQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLIGKKGQQK 10 2 Q71UI9;P0C0S5;Q71UI9-3;Q71UI9-4;A0A494C189 Q71UI9 H2AFV;H2AFZ Histone H2A.V;Histone H2A.Z 2 30406500.0 10015000.0 13956000.0 6435500.0 True False 9697079.306933844 19528703.57957857 4749849.48913835 1.0 2.0138747927548324 0.4898226918430991 23.209118852304062 -6.727322835474506 1.7324772919628977 1.6119367416233603 0.4910771098422426 0.5470356086200785 0.42630652721566537 0.3412820680657261 2.005434629792779 0.19507761157488032 0.48564101237724333 1.8736012372789567e-07 6.727322835474506 -1.1208596317811177 SLIGK(ub)K(ub)GQQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLIGKKGQQK 10 2 Q71UI9;P0C0S5;Q71UI9-3;Q71UI9-4;A0A494C189 Q71UI9 H2AFV;H2AFZ Histone H2A.V;Histone H2A.Z 2 24838200.0 10015000.0 12239000.0 2584200.0 True False 8327916.239726756 12173066.077748708 3124544.2720092097 1.0 1.4617181209963892 0.3751892048462447 22.98952412773834 -6.7912304664767165 1.4912664970433245 1.2576431883949464 0.36321367062738563 0.8053321969005636 0.19644342784002475 0.23351982872335642 1.0258785089738007 0.10367584269371476 0.2425301481035423 1.6172216010483634e-07 6.7912304664767165 -0.8944295177675607 down SLIGVEYKPVSATGAEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLIGVEYKPVSATGAEDK 18 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 29902100.0 9188500.0 9701600.0 11012000.0 False True 12046212.48156057 8254159.096540602 9872583.87456288 1.0 0.6852078285332792 0.8195591676367227 23.52207627597795 -10.13548317376635 4.827182402773911 1.0000164801411566 0.7523834981078034 0.8191394178601532 0.05484870451554005 9.810466846120744e-06 1.756990422964698e-06 0.053110591982318336 0.01770234326176237 7.320096835126422e-11 10.13548317376635 -0.24763298203335327 SLIGVEYKPVSATGAEDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLIGVEYKPVSATGAEDK 18 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 19357800.0 4999700.0 4063100.0 10295000.0 False True 4840987.260197412 5685517.018786589 7598430.6566202035 1.0 1.1744540345174834 1.5696035226315272 22.20686986685403 -6.95754000140853 0.4688189499171104 0.989442330621268 1.7707822363983203 0.999667798388547 0.0043431068636544095 0.08059187065174822 0.024469087286386075 0.005451539877124551 0.032616694200400496 1.1027066625586375e-07 6.95754000140853 0.7813399057770524 SLIGVEYKPVSATGAEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLIGVEYKPVSATGAEDK 18 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 25793700.0 9188500.0 6042200.0 10563000.0 False True 12585736.759875843 5775235.625116563 8068236.9518137425 1.0 0.45887147771343784 0.6410619501860084 23.58528633750084 -10.271767142481405 4.741264481800134 1.0001586719120206 0.5499667139488165 0.8905352182035814 0.0743789489288441 0.00012479511115892983 1.9167938471237243e-05 0.0720422779340102 0.024005702542043865 5.348510558948123e-11 10.271767142481405 -0.4501919579632041 SLIGVEYKPVSATGAEDKDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLIGVEYKPVSATGAEDKDK 20 2 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 18313100.0 6206300.0 6606700.0 5500100.0 False True 8136519.401894699 5621006.112714901 4931002.41268464 1.0 0.6908366876635202 0.6060333871429581 22.955980347170012 -13.999999999999998 0.18150880033958602 2.6116111721810276 0.5397087164970393 0.9994963954043261 0.0037994334110039623 12.2246537244761 0.1350701080918068 6.950601016312866 0.06251468853325874 1.0000000000000041e-14 13.999999999999998 -2.071902455683988 SLIGVEYKPVSATGAEDKDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLIGVEYKPVSATGAEDKDK 20 2 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 16252300.0 2128900.0 11566000.0 2557400.0 False True 3229696.943437612 9501956.934429543 2051928.7690517604 1.0 2.9420583729183853 0.6353316750728124 21.62296736622106 -6.683459195942852 1.8894951095922825 2.2249155109076275 0.6438368259208754 0.34007706345879973 0.8224732224024885 0.43088043993349207 2.977070963915498 0.3488933685161598 0.9161592821246385 2.0727207925303426e-07 6.683459195942852 -1.581078684986752 SLIGVEYKPVSATGAEDKDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLIGVEYKPVSATGAEDKDK 20 2 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 8299300.0 3122600.0 3600800.0 1575900.0 False True 2596580.2546351226 3581401.7756971563 1905413.4038616645 1.0 1.379276365251581 0.7338164882292142 21.30818138599763 -6.747460389171154 1.659206135645237 1.22369847996102 0.7327758303305674 0.6379711630691429 0.15935878943692575 0.3045035836362613 1.648515834239218 0.07589697322593253 0.1847540493824072 1.7887086649630787e-07 6.747460389171154 -0.4909226496304526 SLIGVEYKPVSATGAEDKDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLIGVEYKPVSATGAEDKDKK 21 3 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 24510700.0 8208100.0 4999200.0 11303400.0 False True 10760898.58735347 4253338.846728969 10133832.597869042 1.0 0.3952587055998855 0.9417273581389035 23.35929521918691 -10.529745491244373 9.138787753736196 1.000016708463557 0.6684930318693976 0.32916276971350467 0.22309489319114487 7.595170073326305e-05 3.908209316153544e-06 0.21602156112715473 0.07200356716276884 2.952939224968311e-11 10.529745491244373 -0.3315236765941594 SLIGVEYKPVSATGAEDKDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLIGVEYKPVSATGAEDKDKK 21 3 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 10439900.0 4674900.0 1859300.0 3905700.0 False True 4526497.8584108865 2601728.186121408 2882680.0015115584 1.0 0.5747772930648849 0.6368455463101839 22.109963841149327 -10.478711075740291 6.123983210964703 1.000253127551565 0.6058114196875864 0.9817446237919998 0.02533925827947151 8.762788389271916e-05 7.459110172911873e-06 0.024550071690031247 0.008178210443470122 3.32115331334816e-11 10.478711075740291 -0.3944417078639785 SLIGVEYKPVSATGAEDKDKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLIGVEYKPVSATGAEDKDKK 21 3 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 40525200.0 4339100.0 29217500.0 6968600.0 False True 6582731.930701366 24003408.847630534 5591253.155554121 1.0 3.6464205287899456 0.8493818697791623 22.650255017251876 -6.658674063871282 1.9773051529921772 2.705339161772427 0.8610146231293517 0.23000486689646615 1.127147841254421 0.4876613944234561 3.663711184296267 0.46073832539237647 1.249546230418791 2.1944512436586907e-07 6.658674063871282 -1.8443245386430753 SLIGVEYKPVSATGAEDKDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLIGVEYKPVSATGAEDKDKK 21 3 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 27410800.0 8208100.0 9065300.0 10137400.0 False True 11242856.385562057 8664765.071061725 7743154.9063066 1.0 0.770690718969684 0.6887177635970044 23.422505280709803 -13.999999997394148 0.14324096846225096 2.098911556124053 0.591126498325789 0.9995903333417926 0.0026664416343362115 11.938682179400793 0.11880463814589808 3.660952814965424 0.0874490456615766 1.0000000060001948e-14 13.999999997394148 -1.5077850577982637 SLIINTFYSNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLIINTFYSNK 11 0 Q58FF6 Q58FF6 HSP90AB4P Putative heat shock protein HSP 90-beta 4 0 18315600.0 5766500.0 5936800.0 6612300.0 False True 7559937.342865431 5051052.5814651465 5928122.625660376 1.0 0.6681341858252299 0.7841497034700884 22.849942846692226 -10.351037448266014 4.962340024279839 1.0001648741901008 0.7261419446475895 0.8813685247208296 0.04736313674603466 8.644528512519138e-05 1.1305078240310206e-05 0.04588660458812089 0.015286386653426961 4.456178220878755e-11 10.351037448266014 -0.2740229295425113 SLIINTFYSNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLIINTFYSNK 11 0 Q58FF6 Q58FF6 HSP90AB4P Putative heat shock protein HSP 90-beta 4 0 43024000.0 12838000.0 11026000.0 19160000.0 False True 12430464.71716592 15428739.299830422 14141421.212320842 1.0 1.2412037402370015 1.1376421987499925 23.56737689725665 -10.238395907221266 4.750760163384879 0.9999543749020876 1.1894229694939271 0.8168746658905794 0.04227882227167021 2.043743645999282e-05 3.276294366150761e-06 0.04094614386423197 0.01364543121269865 5.775692893652941e-11 10.238395907221266 0.1894685945918395 SLIINTFYSNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLIINTFYSNK 11 0 Q58FF6 Q58FF6 HSP90AB4P Putative heat shock protein HSP 90-beta 4 0 23506300.0 5422900.0 9369900.0 8713500.0 False True 8226935.767094654 7697768.1376371505 6991272.90573728 1.0 0.9356786482308492 0.8498027824284632 22.971923748841178 -6.967121993657234 0.31958047338547274 1.0118187435114083 0.7708946727384918 0.9999504062420311 0.0004332582164912443 0.07724843830110205 0.012360867400237837 0.001303928014150744 0.007556623006494783 1.0786436878209506e-07 6.967121993657234 -0.24092407077291655 SLIINTFYSNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLIINTFYSNK 11 0 Q58FF6 Q58FF6 HSP90AB4P Putative heat shock protein HSP 90-beta 4 0 19960600.0 5766500.0 5906000.0 8288100.0 False True 7898530.883803019 5645053.391469733 6330621.47877756 1.0 0.7146966283370063 0.8014935399897386 22.913152908215118 -10.304516036322457 7.975035693294065 1.0000006872824583 0.7580950841633726 0.9119459138475652 0.03543469079977091 4.330360044042781e-07 3.7758917157992765e-08 0.034309589480091905 0.011436497278793492 4.960026121628472e-11 10.304516036322457 -0.2419056031190857 SLIINTFYSNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLIINTFYSNK 11 0 Q58FF6 Q58FF6 HSP90AB4P Putative heat shock protein HSP 90-beta 4 0 24872000.0 12838000.0 6429900.0 5604100.0 False True 10675365.819831463 6395260.852464778 6775891.39956923 1.0 0.5990671383442805 0.6347221738276885 23.347782172690927 -9.988021958039027 6.362831610625184 1.00000013940309 0.6168946566421437 0.9935456208848628 0.014556107282564727 2.8785599686216392e-08 4.587918490906634e-09 0.01409389552305429 0.004697963424243318 1.0279643226759637e-10 9.988021958039027 -0.38310548276094625 SLIINTFYSNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLIINTFYSNK 11 0 Q58FF6 Q58FF6 HSP90AB4P Putative heat shock protein HSP 90-beta 4 0 17694900.0 5422900.0 12272000.0 0.0 False True 7020050.951340087 11589052.41204502 0.0 1.0 1.6508501850449873 0.0 22.743050070933627 -6.813897662045013 1.4922526381616574 1.3583210963316863 1.2487486019783125e-21 0.8309038975427219 0.2791982367388602 0.2127819535195035 0.9479212889278597 0.1491780707756118 0.33020546486684266 1.5349786453932962e-07 6.813897662045013 -1.3583210963316863 SLIIVHPSWFIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLIIVHPSWFIR 12 0 J3KN59;Q12982;Q12982-2;H7C096;Q86WG3;Q86WG3-3 J3KN59 BNIP2;ATCAY BCL2/adenovirus E1B 19 kDa protein-interacting protein 2;Caytaxin 0 10943600.0 2220400.0 4392000.0 4331200.0 False True 2910965.902384189 3736730.719881912 3883048.971804094 1.0 1.2836738200270197 1.3339383221987358 21.47306650986718 -12.721433894500137 0.2631143088017102 1.5081355180998545e-10 1.3526506782754402 0.9994787044528972 0.0033565528398216042 7.5457310312459125 0.15640865433002546 4.013717346355781 0.021617862391439962 1.8991799009945376e-13 12.721433894500137 1.3526506781246266 SLIIVHPSWFIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLIIVHPSWFIR 12 0 J3KN59;Q12982;Q12982-2;H7C096;Q86WG3;Q86WG3-3 J3KN59 BNIP2;ATCAY BCL2/adenovirus E1B 19 kDa protein-interacting protein 2;Caytaxin 0 21298000.0 7292000.0 7107300.0 6898700.0 False True 7060519.451439004 9945281.954079872 5091723.513436203 1.0 1.4085765250675606 0.7211542363782397 22.751342897643127 -6.745707612181762 1.6659008747079354 1.2414825716704743 0.7202364046752258 0.6302344404760416 0.17166191955228324 0.30758782902470944 1.6781319712633134 0.08145200847904391 0.19862967733316397 1.795942334189327e-07 6.745707612181762 -0.5212461669952485 SLIIVHPSWFIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLIIVHPSWFIR 12 0 J3KN59;Q12982;Q12982-2;H7C096;Q86WG3;Q86WG3-3 J3KN59 BNIP2;ATCAY BCL2/adenovirus E1B 19 kDa protein-interacting protein 2;Caytaxin 0 43910000.0 12962000.0 12176000.0 18772000.0 False True 19664301.64913253 10003097.668477787 15061705.971940113 1.0 0.508693257811119 0.7659415646018909 24.229075616054363 -10.011138402844441 5.060151800954659 1.0000035953147401 0.6373174112036688 0.7260462785646621 0.10502118148191403 4.2596918267518746e-06 8.324775033887845e-07 0.10168732917448803 0.033895440571793584 9.746789733059753e-11 10.011138402844441 -0.36268618411107134 SLIIVHPSWFIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLIIVHPSWFIR 12 0 J3KN59;Q12982;Q12982-2;H7C096;Q86WG3;Q86WG3-3 J3KN59 BNIP2;ATCAY BCL2/adenovirus E1B 19 kDa protein-interacting protein 2;Caytaxin 0 20219300.0 2220400.0 6975900.0 11023000.0 False True 3041341.8840538017 6667681.671783558 8419594.425811129 1.0 2.192348616491682 2.768381440428085 21.536276571390072 -9.380641371913322 0.21666488211844706 5.3222735753726624e-20 3.256863970327958 0.9993730667468731 0.018438671669925345 0.8029340503446525 0.08332318627402566 0.8433468262053619 0.29802294384058026 4.162541995437354e-10 9.380641371913322 3.256863970327958 SLIIVHPSWFIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLIIVHPSWFIR 12 0 J3KN59;Q12982;Q12982-2;H7C096;Q86WG3;Q86WG3-3 J3KN59 BNIP2;ATCAY BCL2/adenovirus E1B 19 kDa protein-interacting protein 2;Caytaxin 0 16415200.0 7292000.0 3959800.0 5163400.0 False True 6063621.090373194 3938467.7714412427 6243043.067135801 1.0 0.6495240571173032 1.029589905782118 22.531748173077403 -11.936811655167483 13.867142663522252 0.8984152270613398 0.855601283305348 0.0 0.17662658660555014 0.0 0.0 0.0 0.05141168596407154 1.1566137336891218e-12 11.936811655167483 -0.04281394375599179 SLIIVHPSWFIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLIIVHPSWFIR 12 0 J3KN59;Q12982;Q12982-2;H7C096;Q86WG3;Q86WG3-3 J3KN59 BNIP2;ATCAY BCL2/adenovirus E1B 19 kDa protein-interacting protein 2;Caytaxin 0 56935000.0 12962000.0 25638000.0 18335000.0 False True 16779564.51921852 24211222.762386706 14998218.132986933 1.0 1.4428993514495754 0.8938383422173254 24.000201938146812 -6.6920484212798375 1.8593312379307616 1.2771350318820873 0.8956963462025817 0.3799899685541682 0.18723779958567446 0.4122536684585027 2.764842894628204 0.08051640098015944 0.20911556461708378 2.032130427717162e-07 6.6920484212798375 -0.3814386856795057 SLILPYIHKLCK(ub)GMFTK(ub)K(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLILPYIHKLCKGMFTKK 18 3 Q8NB66;A0A3B3ISZ1 Q8NB66 UNC13C Protein unc-13 homolog C 3 41257600.0 8438600.0 15720000.0 17099000.0 True False 12801973.144296391 12914643.179079393 13719375.155242074 1.0 1.008800989778142 1.071660985428204 23.609862851476343 -6.932268742268562 0.7279266232578887 0.9991199562815845 1.085344557035244 0.9969656601083139 0.001757738325098433 0.09147668435330208 0.07203319875435261 0.0016235671664170137 0.005618465474771125 1.1687759263899301e-07 6.932268742268562 0.08622460075365956 SLK(ub)ADLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLKADLQK 8 1 P51572-2;P51572 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 4060160.0 1274100.0 901260.0 1884800.0 True False 1670357.4384019522 766795.5210839639 1689778.9762782515 1.0 0.4590607396088618 1.0116271747769627 20.671725426174156 -10.795028198151535 11.82680328330001 1.0009965976551716 0.7353439572043857 0.23422553696854864 0.2255843025250882 0.005945822909146173 0.00010304744899905392 0.2190823130590818 0.0728070205704569 1.6031412975211798e-11 10.795028198151535 -0.26565264045078585 SLK(ub)ADLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLKADLQK 8 1 P51572-2;P51572 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 5448300.0 1144100.0 1551500.0 2752700.0 True False 1107781.1717486775 2171022.0409656125 2031685.2907701223 1.0 1.9597932302266576 1.8340131991619109 20.079241492577285 -10.173170709277212 5.2247132089867305 0.9999570661668981 1.896903214694748 0.9854643511960646 0.05134948265829436 2.5681570119384242e-05 4.064192572132205e-06 0.04972128898893294 0.016572974264095104 6.711649844793431e-11 10.173170709277212 0.8969461485278499 SLK(ub)ADLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLKADLQK 8 1 P51572-2;P51572 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 4455630.0 1274100.0 804430.0 2377100.0 True False 1745169.201257858 768887.6227057221 1815677.9379112418 1.0 0.4405805592669951 1.040402235268972 20.734935487697047 -11.885846669878694 18.008796970601416 0.9124823442983208 0.7664422575412008 0.0 0.2803504561920081 0.0 0.0 0.0 0.08143603407142502 1.3006286912923845e-12 11.885846669878694 -0.14604008675712 SLK(ub)ADLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLKADLQK 8 1 P51572-2;P51572 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 5111300.0 1144100.0 1991300.0 1975900.0 True False 951369.8422238018 1980572.4716578953 2389051.554470626 1.0 2.081811282800766 2.5111701553270613 19.85964676801156 -9.912241768972299 0.23232785960685845 3.464854556668232e-18 2.7984051682449045 0.9992081599926976 0.017891497497900744 1.3714773188441693 0.10343867197086239 1.1112914752247602 0.2108374643711139 1.2239346529496556e-10 9.912241768972299 2.7984051682449045 SLK(ub)AYGELPEHAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLKAYGELPEHAK 13 1 O14602;A6NJH9;P47813;X6RAC9 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 1 39217600.0 18398000.0 17613000.0 3206600.0 True False 17813965.560556054 24645962.75058161 2366695.264062004 1.0 1.3835191646015679 0.13285617152546741 24.086505374234218 -6.824370872883716 1.3526657321076012 1.2058557975691702 0.1028626902947698 0.8941842905677113 0.17017751749414736 0.1878588769083669 0.6741461770434533 0.09882768908384529 0.22758236787831454 1.49840470175548e-07 6.824370872883716 -1.1029931072744004 down SLK(ub)AYGELPEHAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLKAYGELPEHAK 13 1 O14602;A6NJH9;P47813;X6RAC9 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 1 53079000.0 18398000.0 34681000.0 0.0 True False 15298752.169594893 34494166.569360465 0.0 1.0 2.2547045789731137 0.0 23.866910649668494 -6.7587089100645334 1.6373312440887764 1.7325750817188377 6.0045611779799164e-12 0.6728990837151736 0.5275658011208324 0.2879059537406978 1.524266236962796 0.25514364986919247 0.6091006408895155 1.7429747270663502e-07 6.7587089100645334 -1.7325750817128331 SLK(ub)AYGELPEHAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLKAYGELPEHAK 13 1 O14602;A6NJH9;P47813;X6RAC9 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 1 55763200.0 41666000.0 9405800.0 4691400.0 True False 53937458.359648116 8882358.96163729 3837613.337829009 1.0 0.16467885643425853 0.07114931727483878 25.68478420472603 -13.999999999999998 0.30910950179829394 9.032567997010979 0.050238192297917726 0.9996700372379687 0.007585082438830323 17.206609689611547 0.17686833822242473 88.8526953476423 0.03253009289055832 1.0000000000000041e-14 13.999999999999998 -8.98232980471306 SLK(ub)ELQEMDKDDESLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLKELQEMDKDDESLIK 17 2 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 27657100.0 9400500.0 9055600.0 9201000.0 True False 9102086.273073552 12671548.304330155 6790982.075916708 1.0 1.3921586682622469 0.7460907172464715 23.117765830113413 -6.742401136860765 1.6778614755006618 1.2326865363972561 0.7455096331614998 0.615641857206901 0.1647631027567541 0.3135146212626238 1.7338977128543152 0.0776550631387994 0.19006183707715935 1.8096678175813955e-07 6.742401136860765 -0.48717690323575635 SLK(ub)ELQEMDKDDESLIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLKELQEMDKDDESLIK 17 2 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 36342200.0 11226700.0 9644500.0 15471000.0 True False 17031724.68170934 7923363.622177562 12413150.0688198 1.0 0.4652120539904333 0.7288251953808584 24.021721198098472 -10.531551700648016 7.153625936921812 1.0001795482060987 0.5970186246856458 0.7570359865852017 0.10761961431644967 0.00030831189838574733 2.0189536634141742e-05 0.10424775636024038 0.03473408116440624 2.940683598814277e-11 10.531551700648016 -0.40316092352045285 SLK(ub)ELQEMDKDDESLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLKELQEMDKDDESLIK 17 2 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 11889400.0 3662300.0 6279200.0 1947900.0 True False 5016351.2799361525 6001764.181462361 1487846.138259773 1.0 1.1964401706610048 0.29659927210653997 22.258206948579947 -6.84951653721054 1.2374549261063885 1.104784345245614 0.2609679738799507 0.9395938876322589 0.09494439139416276 0.157990487620739 0.46580371568144685 0.06004577922305006 0.1389045140913697 1.4141108770579848e-07 6.84951653721054 -0.8438163713656635 down SLK(ub)ELQEMDKDDESLIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLKELQEMDKDDESLIK 17 2 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 26001700.0 9400500.0 14192600.0 2408600.0 True False 7816932.262760997 14116141.646789454 2912227.123891877 1.0 1.8058416233228982 0.3725537110978185 22.89817110554769 -6.754113759723654 1.6343084934280172 1.4714737842946064 0.3687272057775207 0.6666390877239485 0.3387143488840804 0.2929052145005716 1.5403729923450578 0.16362778060769273 0.39559238205478936 1.7615145723042053e-07 6.754113759723654 -1.1027465785170856 SLK(ub)ELQEMDKDDESLIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLKELQEMDKDDESLIK 17 2 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 37449000.0 11226700.0 15772300.0 10450000.0 True False 14533184.461341675 14894557.640034016 8548207.226054724 1.0 1.0248653816824245 0.5881854213571008 23.79284752019092 -6.893405234129156 1.0019994484696222 1.0215839817286398 0.548019012673746 0.9829905534898017 0.026116598844435287 0.11642455958830272 0.20604656060829293 0.019765282654917542 0.049920341486321296 1.2781880880640645e-07 6.893405234129156 -0.47356496905489387 SLK(ub)GLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLKGLVK 7 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 1 8509800.0 3099900.0 3352700.0 2057200.0 True False 4063998.919474303 2852490.2287222436 1844340.678055824 1.0 0.7018924673068629 0.45382410640364984 21.954468587854215 -7.1997013306174775 0.1810653757034793 1.2049837547604048 9.960134637018461e-11 0.9999922685390612 0.0006208341780506296 0.09118924324941086 0.008406949911588276 0.015282100218635446 0.03728870106828868 6.313914104469658e-08 7.1997013306174775 -1.2049837546608033 down SLK(ub)GLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLKGLVK 7 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 1 23042600.0 4856500.0 7474100.0 10712000.0 True False 4702333.0658137 10458547.106916592 7906205.846888343 1.0 2.2241187428748894 1.6813368462491585 22.164945297889755 -10.031805561650582 5.661766196306435 0.9999968574868745 1.9527277945623691 0.8042269438484297 0.22158978139340768 8.79000720335667e-06 1.5026272899746554e-06 0.21455408624866762 0.07151779441869 9.293823882230524e-11 10.031805561650582 0.9527309370754946 SLK(ub)GLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLKGLVK 7 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 1 11886200.0 2942900.0 3335100.0 5608200.0 True False 4464594.454808838 2739925.3477447676 4499736.811838619 1.0 0.6137008356478112 1.0078713436092566 22.090097702205192 -10.87668584575218 11.068925821158873 1.0081657827848423 0.8107860896286482 0.23502905086300652 0.16091943602653258 0.03242551794478673 0.00036123803610573055 0.15579987245498292 0.05193652465098751 1.328354998297422e-11 10.87668584575218 -0.19737969315619408 SLK(ub)GLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLKGLVK 7 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 1 8292500.0 3099900.0 2620500.0 2572100.0 True False 4246016.801647619 2504717.645165326 1964622.954062305 1.0 0.5898981945133609 0.4626978756419322 22.017678649377107 -13.999999999999998 0.1639226926004211 3.037336660113902 0.3429121789432081 0.9995266045434098 0.004988238694569737 12.038145152212387 0.12806776330110067 7.7965436049267645 0.10973694943177595 1.0000000000000041e-14 13.999999999999998 -2.694424481170694 SLK(ub)GLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLKGLVK 7 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 1 23437200.0 4856500.0 16229000.0 2351700.0 True False 4038394.9294291544 16141571.155795703 2843429.5969677498 1.0 3.997026402288344 0.7040989419451558 21.94535057332403 -6.6671517194647185 1.947459914895385 2.917630475678306 0.717551379460967 0.2665341941886763 1.2739080277286936 0.4676665252465064 3.4166741722636176 0.5271344809677019 1.413627957419753 2.1520297982825407e-07 6.6671517194647185 -2.200079096217339 SLK(ub)GLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLKGLVK 7 1 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 1 9372400.0 2942900.0 3796200.0 2633300.0 True False 3809642.0632316153 3584938.132872005 2154066.4199397056 1.0 0.9410170492056673 0.5654248835420695 21.86122402429764 -6.9345894845030305 0.708109838681523 1.0048563376694688 0.47845878701575034 0.9973658017284378 0.009878438522440369 0.09032398415018399 0.0665133875348013 0.009259461836607414 0.03316903717629481 1.1625469885358354e-07 6.9345894845030305 -0.5263975506537184 SLK(ub)QNINLSAPIMSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLKQNINLSAPIMSR 15 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 5874800.0 2784600.0 3090200.0 0.0 True False 2696204.3972129743 4324132.975180111 0.0 1.0 1.60378529893724 0.0 21.362498439607975 -6.820640552820196 1.475563140856123 1.3301501120069243 4.1535228063882555e-22 0.8450061894793317 0.2603761487260962 0.20505957756759738 0.8941896301444171 0.14088198649275518 0.3090765841541386 1.5113305010166794e-07 6.820640552820196 -1.3301501120069243 SLK(ub)QNINLSAPIMSR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SLKQNINLSAPIMSR 15 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 55101700.0 18560600.0 25317300.0 11223800.0 True False 15433961.273996258 25180910.67980944 13570644.68701221 1.0 1.6315261022609422 0.8792716559342781 23.879605055147664 -6.684047953800709 1.887419846843763 1.398113779969935 0.8820339612468386 0.34275379873230805 0.26742244144349353 0.4296103895701395 2.962272134437034 0.11354507127482935 0.29793277895967635 2.0699127811500252e-07 6.684047953800709 -0.5160798187230964 SLK(ub)QNINLSAPIMSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLKQNINLSAPIMSR 15 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 64906000.0 17340000.0 25747000.0 21819000.0 True False 22446971.822500315 24314156.816568043 17848165.88184577 1.0 1.083182043833463 0.7951257756716739 24.42001749753753 -6.829461354678017 1.3302274528246938 1.0444650937273527 0.7874547629917246 0.9048045993304792 0.03734721893004309 0.1814806783645678 0.6282251621980716 0.022044657450904323 0.050734419276319234 1.4809440299388112e-07 6.829461354678017 -0.2570103307356282 SLK(ub)SDMMSHLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLKSDMMSHLVK 12 1 P33992;B1AHA9 P33992 MCM5 DNA replication licensing factor MCM5 1 6640000.0 1432700.0 2119300.0 3088000.0 True False 1387219.7227203308 2965547.5420035017 2279160.1619857396 1.0 2.1377633935221727 1.6429698371908368 20.403764884579996 -10.421507669616984 5.447471658007114 0.9993715825030635 1.8903666153565108 0.8119403148395188 0.2019986235048264 0.0015426683015784188 0.0001638230918788272 0.19571007785351285 0.06519477539924785 3.788718428331711e-11 10.421507669616984 0.8909950328534474 SLK(ub)SDMMSHLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLKSDMMSHLVK 12 1 P33992;B1AHA9 P33992 MCM5 DNA replication licensing factor MCM5 1 6550200.0 1432700.0 2817000.0 2300500.0 True False 1191353.5293715943 2801824.261869282 2781523.913689801 1.0 2.351799187053373 2.3347594522651702 20.184170160014272 -10.027750819321803 4.951707952419702 0.999979651491023 2.3432793196714914 0.9998793292078195 0.006956442648678727 1.5820563459309815e-06 3.106359477734931e-07 0.006735649503592901 0.0022451822032384296 9.381000965881676e-11 10.027750819321803 1.3432996681804683 SLK(ub)STQDEINQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLKSTQDEINQAR 13 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R2S2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 7421600.0 1920400.0 3332600.0 2168600.0 True False 2517662.9971800554 2835389.070373058 1944214.074680079 1.0 1.126198809590035 0.7722296736527978 21.263653752764192 -6.810293670768114 1.413156968539841 1.0687534613844738 0.7659867753582943 0.8606312872590618 0.05468296897210108 0.20639721615600892 0.812290279148813 0.030425155037568374 0.07037496843763495 1.5477696601387214e-07 6.810293670768114 -0.3027666860261795 SLK(ub)STQDEINQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLKSTQDEINQAR 13 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R2S2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 14745860.0 4696860.0 4155600.0 5893400.0 True False 4547760.750231182 5814952.751167708 4349741.741789747 1.0 1.2786408675680903 0.9564579098776538 22.116724927878412 -6.677918794045677 1.909012185737219 1.176623260693968 0.9576948781932396 0.31476226928311135 0.11814795854175163 0.44315190952072897 3.120517447270463 0.04969085352741256 0.13141973861206474 2.0993323876956596e-07 6.677918794045677 -0.21892838250072832 SLK(ub)STQDEINQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLKSTQDEINQAR 13 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R2S2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 16120820.0 4696860.0 8915260.0 2508700.0 True False 3905647.196178034 8867231.724839445 3033257.5710817673 1.0 2.270361678729377 0.7766337865975287 21.897130203312688 -6.681445042452173 1.8970181871624114 1.8027567103089415 0.782299249792166 0.33057348930787367 0.5382453242331006 0.4353570117073798 3.0303871689354818 0.22757933685249548 0.5990581143103161 2.082355899089008e-07 6.681445042452173 -1.0204574605167753 SLLALINVLNALADAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLLALINVLNALADAK 16 0 A0A494BYR6;Q86Y91-6;Q86Y91 A0A494BYR6 KIF18B Kinesin-like protein KIF18B 0 106269000.0 52416000.0 0.0 53853000.0 False True 79518904.12289251 0.0 43208930.94539158 1.0 0.0 0.5433793564183722 26.244794538976894 -10.122263492188335 5.724700869826225 1.0000068791933352 0.27168967820912715 0.7054778382702056 0.22183369333136538 1.9476901050808254e-05 2.986706507401323e-06 0.2147915773626195 0.07159651665830775 7.546342422019918e-11 10.122263492188335 -0.728317200984208 SLLASLHTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLLASLHTSR 10 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;A0A0A0MSW0;X6RE05 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 0 3770950.0 0.0 794150.0 2976800.0 False True 0.0 675665.915572455 2668789.2914819065 0.0 SLLELAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLLELAR 7 0 P49321;P49321-2;P49321-3;E9PI86;E9PPQ8;E9PPR5 P49321 NASP Nuclear autoantigenic sperm protein 0 10207800.0 2869100.0 3882100.0 3456600.0 False True 3761417.8844039207 3302905.812307278 3098944.190048492 1.0 0.8781012676103379 0.823876603261163 21.842845164526302 -13.99999999847846 0.10970244025708194 1.5884823785288884 0.7239760258350553 0.9997445683405658 0.0011770790180485738 12.01439650795088 0.10045818643927527 1.566870999350327 0.08873914169254171 1.0000000035034758e-14 13.99999999847846 -0.8645063526938331 SLLELAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLELAR 7 0 P49321;P49321-2;P49321-3;E9PI86;E9PPQ8;E9PPR5 P49321 NASP Nuclear autoantigenic sperm protein 0 7066700.0 3454800.0 1387600.0 2224300.0 False True 3345129.265061909 1941675.916238404 1641689.102430335 1.0 0.5804486949183619 0.4907700038910012 21.67363053100122 -13.999999999999998 0.21685210198108035 3.4973769918574575 0.441329437335444 0.9994949408834413 0.004988132495626472 12.915828263696051 0.1475465510106288 13.790067634204464 0.05068120868780959 1.0000000000000041e-14 13.999999999999998 -3.0560475545220136 SLLELAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLLELAR 7 0 P49321;P49321-2;P49321-3;E9PI86;E9PPQ8;E9PPR5 P49321 NASP Nuclear autoantigenic sperm protein 0 40119800.0 6097300.0 30266000.0 3756500.0 False True 9250049.872338818 24864795.830662698 3014026.128467561 1.0 2.6880715427295083 0.32583890574262203 23.14102971337279 -6.714855936598217 1.7779552138017203 2.032592084674106 0.33056513844503516 0.4881392816534623 0.710827696306012 0.3653785804815445 2.2543566115506475 0.31781337976355667 0.802658847353945 1.9281644144266276e-07 6.714855936598217 -1.702026946229071 SLLELAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLLELAR 7 0 P49321;P49321-2;P49321-3;E9PI86;E9PPQ8;E9PPR5 P49321 NASP Nuclear autoantigenic sperm protein 0 10157600.0 2869100.0 3844200.0 3444300.0 False True 3929883.804512138 3674350.532930567 2630827.27758516 1.0 0.9349768888107639 0.6694414920269519 21.906055226049194 -6.944399383745533 0.6172834799893391 1.0029124313622004 0.5875038667425111 0.9986851593678366 0.005184787987864515 0.08581579038400051 0.04589268591224122 0.00523449507740521 0.022449533571471694 1.136581587533673e-07 6.944399383745533 -0.41540856461968934 SLLELAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLLELAR 7 0 P49321;P49321-2;P49321-3;E9PI86;E9PPQ8;E9PPR5 P49321 NASP Nuclear autoantigenic sperm protein 0 5988180.0 3454800.0 1762200.0 771180.0 False True 2872819.2735904115 1752706.678830687 932430.1724665504 1.0 0.6100998746921442 0.32456972878116747 21.454035806435495 -7.954672624875683 0.2190038793525817 1.2147569523978026 1.6265897351558264e-16 0.9997873381323127 0.004037111441848027 0.10809201630246836 0.03723651232242194 0.06927023761016 0.09773184125027601 1.110011236522003e-08 7.954672624875683 -1.2147569523978023 down SLLELAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLLELAR 7 0 P49321;P49321-2;P49321-3;E9PI86;E9PPQ8;E9PPR5 P49321 NASP Nuclear autoantigenic sperm protein 0 14919700.0 6097300.0 4826000.0 3996400.0 False True 7893075.045751508 4557428.85760505 3269096.206526805 1.0 0.5773958604458109 0.4141727004466294 22.91215603546524 -13.999999999999998 0.1316882191365798 3.008985947805616 0.19041619134154747 0.9996380414345951 0.0046964350737900475 11.934495718904287 0.11301333678909382 6.196833602817589 0.19912696207196273 1.0000000000000041e-14 13.999999999999998 -2.8185697564640684 SLLHGDFHAFSAGPGLFSYIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLHGDFHAFSAGPGLFSYIR 21 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5GZI0 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 33957800.0 21886600.0 7707700.0 4363500.0 False True 21191821.863119133 10785424.805124495 3220568.4478059453 1.0 0.5089427834373573 0.1519722310147771 24.3370042858953 -8.133200107830456 0.34362606138660345 1.1020702509784537 8.043304101307002e-18 0.9984184634152045 0.013825350158430878 0.09269936386477205 0.07781569434649097 0.06465933430234312 0.08812225473781693 7.3586795694324946e-09 8.133200107830456 -1.1020702509784537 down SLLHGDFHAFSAGPGLFSYIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLLHGDFHAFSAGPGLFSYIR 21 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5GZI0 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 90947000.0 35570000.0 17705000.0 37672000.0 False True 53962290.51532511 14545404.420203608 30226112.687775806 1.0 0.2695475725974375 0.5601339824370816 25.685448251285095 -10.432083543739452 6.039386799162819 1.0002174737810179 0.4148407775186988 0.8439146080627973 0.11863140504906665 0.0003475030868263307 3.2677429555978216e-05 0.11490599373700527 0.03828812134101839 3.697570440444626e-11 10.432083543739452 -0.585376696262319 SLLHGDFHAFSAGPGLFSYIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLLHGDFHAFSAGPGLFSYIR 21 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5GZI0 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 40540700.0 21886600.0 8320100.0 10334000.0 False True 18199677.64077918 8275277.969889457 12494791.62098258 1.0 0.454693656295726 0.6865391721546802 24.117409561329577 -10.30389471258685 5.731370336600018 1.0000439752424992 0.5706164142252024 0.8205739437031567 0.09465053550114146 5.319075289857341e-05 6.460358844345601e-06 0.0916543420879443 0.030548328975459622 4.967127265243309e-11 10.30389471258685 -0.42942756101729684 SLLHGDFHAFSAGPGLFSYIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLLHGDFHAFSAGPGLFSYIR 21 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5GZI0 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 64342000.0 35570000.0 11059000.0 17713000.0 False True 46046066.18952343 10443556.928357694 14489415.750727983 1.0 0.22680671320265466 0.3146721739722615 25.456574573377544 -10.594234361386276 6.494806109615766 1.001688548641281 0.27073944366784564 0.9892296618824438 0.03587092415001161 0.0008785182109606675 5.488572748917764e-05 0.034790031202711756 0.011577290987172034 2.5454562594225265e-11 10.594234361386276 -0.7309491049734353 SLLIGVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLLIGVFK 8 0 Q9HCK8;Q9HCK8-2;A0A2R8Y840;H0YJG4;Q9P2D1;Q3L8U1;Q3L8U1-3;Q3L8U1-2;H3BTW3;Q8TD26;A0A087WU44;H7C294;Q8TD26-3;C9JFU2 Q9HCK8 CHD8;CHD7;CHD9;CHD6 Chromodomain-helicase-DNA-binding protein 8;Chromodomain-helicase-DNA-binding protein 7;Chromodomain-helicase-DNA-binding protein 9;Chromodomain-helicase-DNA-binding protein 6 0 5393500.0 1112800.0 1167200.0 3113500.0 False True 1458891.5763705298 993058.3097099647 2791344.8868009 1.0 0.6806937032157813 1.913332650631436 20.476441236647837 -6.8379265980145645 1.2919633927453333 0.8300621224055906 1.9522454658021529 0.9208334213441546 0.14696789234443716 0.1712352766055152 0.5560996607667799 0.0892278177140595 0.20546658843013516 1.4523570659832267e-07 6.8379265980145645 1.1221833433965622 SLLIGVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLIGVFK 8 0 Q9HCK8;Q9HCK8-2;A0A2R8Y840;H0YJG4;Q9P2D1;Q3L8U1;Q3L8U1-3;Q3L8U1-2;H3BTW3;Q8TD26;A0A087WU44;H7C294;Q8TD26-3;C9JFU2 Q9HCK8 CHD8;CHD7;CHD9;CHD6 Chromodomain-helicase-DNA-binding protein 8;Chromodomain-helicase-DNA-binding protein 7;Chromodomain-helicase-DNA-binding protein 9;Chromodomain-helicase-DNA-binding protein 6 0 3240600.0 856690.0 558310.0 1825600.0 False True 829494.844878398 781246.0945481881 1347420.5931739532 1.0 0.9418335742191587 1.624386940429367 19.661873489624604 -6.886183095148452 1.0447410480839938 0.9598997894009557 1.6788748914880975 0.9783390081519144 0.04547211982054859 0.12229286814642149 0.24039809638253615 0.03331966126267635 0.08200008769173332 1.2996215522630702e-07 6.886183095148452 0.7189751020871419 SLLIGVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLLIGVFK 8 0 Q9HCK8;Q9HCK8-2;A0A2R8Y840;H0YJG4;Q9P2D1;Q3L8U1;Q3L8U1-3;Q3L8U1-2;H3BTW3;Q8TD26;A0A087WU44;H7C294;Q8TD26-3;C9JFU2 Q9HCK8 CHD8;CHD7;CHD9;CHD6 Chromodomain-helicase-DNA-binding protein 8;Chromodomain-helicase-DNA-binding protein 7;Chromodomain-helicase-DNA-binding protein 9;Chromodomain-helicase-DNA-binding protein 6 0 4416800.0 1112800.0 1057800.0 2246200.0 False True 1524232.2322892584 1011062.898323177 1715693.821941117 1.0 0.6633260187685786 1.1256118231828103 20.539651298170728 -6.711412602971024 1.7900116844485812 0.793318946298437 1.1245782254526515 0.4718398992763102 0.14184194047640208 0.37226447254864736 2.3259657511159335 0.06303616941564194 0.15987724030944758 1.9435127632293916e-07 6.711412602971024 0.3312592791542145 SLLINAVEASCIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLLINAVEASCIR 13 0 A0A087WTV6;Q96C36;A0A087WZR9;J3KR12;P32322-2;P32322;P32322-3;E2QRB3;J3QKT4 A0A087WTV6;P32322-2 PYCR2;PYCR1 Pyrroline-5-carboxylate reductase 2;Pyrroline-5-carboxylate reductase;Pyrroline-5-carboxylate reductase 1, mitochondrial 0 10224000.0 1744300.0 4220500.0 4259200.0 False True 2286794.1918252283 3590817.8513801517 3818498.841131328 1.0 1.570240935636671 1.6698043290391402 21.124895100445936 -11.522237452060404 0.30044439222362834 8.843515524405943e-09 1.6975105164414108 0.999382147703716 0.007335047214363784 3.9616730185059175 0.160498320437303 2.5994564896422907 0.03583952740630922 3.0044331688998416e-12 11.522237452060404 1.6975105075978953 SLLINAVEASCIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLINAVEASCIR 13 0 A0A087WTV6;Q96C36;A0A087WZR9;J3KR12;P32322-2;P32322;P32322-3;E2QRB3;J3QKT4 A0A087WTV6;P32322-2 PYCR2;PYCR1 Pyrroline-5-carboxylate reductase 2;Pyrroline-5-carboxylate reductase;Pyrroline-5-carboxylate reductase 1, mitochondrial 0 8943400.0 4880000.0 1988500.0 2074900.0 False True 4725087.071176947 2782518.419890508 1531421.4443342637 1.0 0.5888819355020742 0.32410438607066977 22.17190948405424 -8.428426056458113 0.19542525505537586 1.3138142236235482 1.365311527446144e-22 0.9997509587472545 0.004388399782847696 0.12867966538370582 0.04729700125858037 0.13983046002242785 0.12515207391840383 3.728841672805643e-09 8.428426056458113 -1.3138142236235482 down SLLINAVEASCIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLLINAVEASCIR 13 0 A0A087WTV6;Q96C36;A0A087WZR9;J3KR12;P32322-2;P32322;P32322-3;E2QRB3;J3QKT4 A0A087WTV6;P32322-2 PYCR2;PYCR1 Pyrroline-5-carboxylate reductase 2;Pyrroline-5-carboxylate reductase;Pyrroline-5-carboxylate reductase 1, mitochondrial 0 10079400.0 1744300.0 3087600.0 5247500.0 False True 2389214.847935076 2951179.6226721895 4008148.5756548927 1.0 1.2352089747068173 1.6776007311016885 21.188105161968828 -6.961228159222858 0.4177643420322143 0.9799684420921947 1.949468374292169 0.9998130720228114 0.0038405953338580185 0.07926527950371792 0.019531563875118764 0.005715084636822953 0.036848955567270206 1.09338180064254e-07 6.961228159222858 0.9694999321999743 SLLINAVEASCIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLLINAVEASCIR 13 0 A0A087WTV6;Q96C36;A0A087WZR9;J3KR12;P32322-2;P32322;P32322-3;E2QRB3;J3QKT4 A0A087WTV6;P32322-2 PYCR2;PYCR1 Pyrroline-5-carboxylate reductase 2;Pyrroline-5-carboxylate reductase;Pyrroline-5-carboxylate reductase 1, mitochondrial 0 10522600.0 2424000.0 5439900.0 2658700.0 False True 3137915.78418344 5137164.782943583 2174843.8805657146 1.0 1.6371264037222706 0.6930854841700796 21.581375202901285 -6.7249235236681 1.7418260510908898 1.385572126703437 0.6941552663332478 0.5355529816553359 0.2679559740743342 0.34583180571523586 2.0531049496659035 0.12203288008558692 0.3045622548033233 1.8839808166086513e-07 6.7249235236681 -0.6914168603701893 SLLKPFCAALLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLLKPFCAALLK 12 1 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 6608700.0 1948400.0 2118500.0 2541800.0 False True 2554371.2683324423 1802428.0578483215 2278798.918667264 1.0 0.7056249340860273 0.8921173468079764 21.284536799946046 -10.729693461891719 5.539848238008745 1.0063976016022158 0.7988711404470158 0.6079712808119058 0.07613520867821692 0.006166444019052917 0.00030087979533002183 0.07556203162137987 0.024572532939230046 1.863401917724254e-11 10.729693461891719 -0.20752646115520001 SLLKPFCAALLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLLKPFCAALLK 12 1 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 5752700.0 1819800.0 0.0 3932900.0 False True 2760769.6452006926 0.0 3155560.59114869 1.0 0.0 1.1430003211728657 21.396639085793847 -10.691170474374298 4.4449140805733105 1.0181647656267498 0.5715001605935397 0.15781701404189974 0.4666279271186678 0.08462706263220832 0.00587982500907544 0.45519756434550396 0.15060351588379625 2.0362426309224198e-11 10.691170474374298 -0.44666460503321015 SLLKPFCAALLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLLKPFCAALLK 12 1 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 8061100.0 1948400.0 2197800.0 3914900.0 False True 2668776.1335301874 2100693.9288473018 2990281.2498963927 1.0 0.787137558094301 1.1204691215298477 21.347746861468938 -6.734204956563938 1.707877461788806 0.8725039916372348 1.1204288419420865 0.5786514504362514 0.08945665536114884 0.32841345850280423 1.8784933027662705 0.04147655173255739 0.10243574687346545 1.8441449066106234e-07 6.734204956563938 0.24792485030485167 SLLKPFCAALLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLLKPFCAALLK 12 1 Q14008-2;Q14008;Q14008-3 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 11376800.0 1819800.0 5415700.0 4141300.0 False True 2355766.9736208813 5114311.5342170885 3387625.893326357 1.0 2.1709751395131605 1.4380140019195018 21.167765407886296 -10.256741759599755 5.647647754151247 0.9999709834654761 1.8044945703549615 0.6163123627036579 0.2992301316691011 0.0001922880265963919 2.5306167956672328e-05 0.28974658346260834 0.09657610967915117 5.536792403765162e-11 10.256741759599755 0.8045235868894854 SLLLLAYLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLLLLAYLIR 10 0 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 0 458920000.0 124700000.0 165590000.0 168630000.0 False True 189179016.79114547 136039170.73942488 135300206.58684525 1.0 0.719102853196519 0.715196689790482 27.495176836940278 SLLLLAYLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLLLLAYLIR 10 0 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 0 465140000.0 124700000.0 192130000.0 148310000.0 False True 161426608.2044862 181437796.6041566 121319101.78910796 1.0 1.1239646215840784 0.7515433988145729 27.266303159032727 -6.816968274040634 1.3848851493271457 1.0670288571971207 0.7439264498750873 0.8772748588718042 0.054245870438513255 0.19745443597089377 0.744918278085779 0.030786542671791383 0.0710236657585409 1.5241640925406931e-07 6.816968274040634 -0.32310240732203344 SLLLSVNAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLLLSVNAR 9 0 Q14697;F5H6X6;Q14697-2;E9PKU7;E9PNH1 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 88993000.0 25952000.0 30856000.0 32185000.0 False True 34023323.31952546 26252405.075745963 28854804.940320212 1.0 0.7716002587166467 0.8480889614848672 25.02002073121023 -10.500794620275666 8.620947919098242 1.0000094511588005 0.809844610100757 0.8917824915014493 0.03122638214492457 5.672612871736526e-06 3.2848899926301487e-07 0.03023631602959586 0.010078271500800122 3.1564969914470286e-11 10.500794620275666 -0.19016484105804343 SLLLSVNAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLLSVNAR 9 0 Q14697;F5H6X6;Q14697-2;E9PKU7;E9PNH1 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 117831000.0 52310000.0 29585000.0 35936000.0 False True 50649447.6830463 41398444.78373682 26523283.543108642 1.0 0.8173523439544625 0.5236638256963003 25.59404320116935 -6.964076542136299 0.3735618727353596 1.021692295278497 0.3090435378214259 0.9998928253200629 0.00203133014401312 0.07827574117976975 0.015973468068907967 0.0038513491863489185 0.02489604145490736 1.0862341636422481e-07 6.964076542136299 -0.7126487574570711 SLLLSVNAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLLLSVNAR 9 0 Q14697;F5H6X6;Q14697-2;E9PKU7;E9PNH1 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 373938000.0 98558000.0 131000000.0 144380000.0 False True 149519691.55494553 107622026.49232833 115843229.71599792 1.0 0.7197849686091639 0.7747690522316776 27.15576025715356 -10.68557119300151 6.716874258423809 1.0019528369800526 0.7472770104204215 0.9657157168189187 0.022447158141613317 0.0006609124876710991 3.09384640582908e-05 0.02188237911428284 0.007244789137679383 2.0626655110784447e-11 10.68557119300151 -0.25467582655963106 SLLLSVNAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLLLSVNAR 9 0 Q14697;F5H6X6;Q14697-2;E9PKU7;E9PNH1 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 130782000.0 25952000.0 39334000.0 65496000.0 False True 35547155.72642952 37596093.81985619 50027193.732461624 1.0 1.0576400010508653 1.4073473027622885 25.083230792733122 -6.93559951678273 0.699299005725861 0.9956214477141946 1.4905796196950036 0.9975289160845754 0.008947021310792906 0.08983254917619247 0.06418771262447677 0.008442307130785243 0.030726940462262223 1.1598464116912622e-07 6.93559951678273 0.49495817198080905 SLLLSVNAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLLLSVNAR 9 0 Q14697;F5H6X6;Q14697-2;E9PKU7;E9PNH1 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 93428000.0 52310000.0 19375000.0 21743000.0 False True 43498082.72592172 19270623.02936362 26289360.771726735 1.0 0.4430223545894293 0.6043797593878816 25.374448476603625 -10.775090938841387 10.612468998148035 1.0019545157695746 0.523701056988712 0.9207462550582479 0.06587388466265368 0.003051827463936839 6.467697445120103e-05 0.06389808353422863 0.021260704854037145 1.6784525227298353e-11 10.775090938841387 -0.47825345878086256 SLLLSVNAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLLLSVNAR 9 0 Q14697;F5H6X6;Q14697-2;E9PKU7;E9PNH1 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 350648000.0 98558000.0 134490000.0 117600000.0 False True 127585273.86862665 127005513.27378857 96198006.67789827 1.0 0.9954558972422236 0.7539898905335458 26.92688657924601 -6.910976175676981 0.8890630388322295 1.007247412392681 0.7221242340631887 0.991284718102443 0.010727890844332823 0.10377596142072598 0.13529274338362945 0.00882568227625984 0.024530773952449784 1.2275065672910527e-07 6.910976175676981 -0.2851231783294922 SLLPRPPAVSHTQPWYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLPRPPAVSHTQPWYR 17 1 Q8N8I6 Q8N8I6 LINC00482 Putative uncharacterized protein encoded by LINC00482 0 9566300.0 2870400.0 1366100.0 5329800.0 False True 2779280.7231775196 1911590.854117387 3933765.489427322 1.0 0.6878005658715494 1.4153897649208653 21.40628013163589 -6.790107707229798 1.4958573620211402 0.8255302698773899 1.4231542556844283 0.8016566937764174 0.13273041629358168 0.23520844393385443 1.0397148722016845 0.06984075176762779 0.16350466727918475 1.6214079301174195e-07 6.790107707229798 0.5976239858070385 SLLPVK(ub)PVEIEIETPEQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLLPVKPVEIEIETPEQAK 19 1 Q01831;E7EUB5 Q01831 XPC DNA repair protein complementing XP-C cells 1 7828600.0 1708800.0 2681100.0 3438700.0 True False 2240253.3480427386 2281090.3308459483 3082896.310339569 1.0 1.018228734191554 1.3761373520691442 21.09523046379315 -6.917469534976564 0.8432865223024586 0.9913600347645655 1.4306218410521774 0.993448547356093 0.01401706665813974 0.09968358615106669 0.11349999125784506 0.011918023418706455 0.03488018696598861 1.209290009616999e-07 6.917469534976564 0.4392618062876119 SLLPVK(ub)PVEIEIETPEQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLPVKPVEIEIETPEQAK 19 1 Q01831;E7EUB5 Q01831 XPC DNA repair protein complementing XP-C cells 1 32831100.0 12494000.0 9627100.0 10710000.0 True False 12097384.808869824 13471251.234663289 7904729.706887055 1.0 1.1135672252722046 0.6534246725037045 23.528191866169504 -6.841402577263404 1.275819637715165 1.0604084556878473 0.637860474952621 0.9268493746276173 0.052934105882443475 0.16716361888193298 0.5279323993225208 0.032525690834679453 0.07496533248182706 1.4407791755490655e-07 6.841402577263404 -0.42254798073522626 SLLPVK(ub)PVEIEIETPEQAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLLPVKPVEIEIETPEQAK 19 1 Q01831;E7EUB5 Q01831 XPC DNA repair protein complementing XP-C cells 1 64865000.0 13391000.0 24646000.0 26828000.0 True False 20315126.013233613 20247728.739923082 21525434.040869854 1.0 0.9966824092911544 1.05957669309301 24.2760509777396 -6.89445021170055 0.9956627674176551 0.9969722437689406 1.0654828920159438 0.9835978396444687 0.003701045639838781 0.11560747968648075 0.20133985584001896 0.0028143636271243827 0.007138677054236534 1.2751162731845898e-07 6.89445021170055 0.06851064824700326 SLLPVK(ub)PVEIEIETPEQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLLPVKPVEIEIETPEQAK 19 1 Q01831;E7EUB5 Q01831 XPC DNA repair protein complementing XP-C cells 1 7914300.0 1708800.0 3470900.0 2734600.0 True False 2340589.5385836475 3317544.161268591 2088743.8008548578 1.0 1.41739681673367 0.8924007248698599 21.158440525316042 -6.694853600863865 1.8489703924816183 1.260475834489541 0.8940903821457961 0.3933465730163753 0.17635859199266996 0.40630635733136095 2.6966549020444273 0.07619618068715306 0.19722936971551933 2.01904686254532e-07 6.694853600863865 -0.366385452343745 SLLPVK(ub)PVEIEIETPEQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLLPVKPVEIEIETPEQAK 19 1 Q01831;E7EUB5 Q01831 XPC DNA repair protein complementing XP-C cells 1 22705000.0 12494000.0 6783200.0 3427800.0 True False 10389314.578047523 6746657.555240212 4144537.1316435095 1.0 0.6493842788720446 0.3989230570032848 23.30859714160378 -7.932025251783276 0.17708743930479018 1.285877768372711 3.742117051021462e-15 0.9999137540296793 0.0022894061579735447 0.11339682723974571 0.028436993187803856 0.07665390192255626 0.10250878382685301 1.169431393180035e-08 7.932025251783276 -1.2858777683727072 down SLLPVKPVEIEIETPEQAK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLPVKPVEIEIETPEQAKTR 21 2 Q01831 Q01831 XPC DNA repair protein complementing XP-C cells 1 37695900.0 10883700.0 9389000.0 17423200.0 True False 10538202.900936166 13138076.662988193 12859541.235203983 1.0 1.2467094044868947 1.2202783867505151 23.329125526731175 -10.0423836535361 4.4893852138265435 0.9999883055339136 1.2334938956179509 0.990481153584947 0.010790417870704174 5645440.498255561 0.017695345103798985 684.3314923502024 0.003948888584903839 9.070189202610104e-11 10.0423836535361 0.23350559008403726 SLLPVKPVEIEIETPEQAK(ub)TR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLLPVKPVEIEIETPEQAKTR 21 2 Q01831 Q01831 XPC DNA repair protein complementing XP-C cells 1 46221900.0 12850900.0 11469000.0 21902000.0 True False 19495754.82663456 9422267.342293989 17573060.100012377 1.0 0.48329841168404253 0.9013788004763247 24.216656677554973 -9.974805857278248 6.958777243716489 1.0000000225930739 0.6923386060801847 0.41929557869594036 0.17068060400091864 5.986834775321451e-08 8.67008048818153e-09 0.1652607952856217 0.055086928068014754 1.0597273493694489e-10 9.974805857278248 -0.30766141651288914 SLLPVKPVEIEIETPEQAK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLLPVKPVEIEIETPEQAKTR 21 2 Q01831 Q01831 XPC DNA repair protein complementing XP-C cells 1 18856100.0 10883700.0 7972400.0 0.0 True False 9050278.779661901 7929451.098802504 0.0 1.0 0.8761554524289175 0.0 23.10953080216545 -7.1447384963711125 0.9430098966526389 0.994717621635514 1.4441834958813926e-20 0.9896927191772226 0.04518816898941953 0.0874127728700985 0.14720410940932024 0.03775214920497734 0.06633992035889728 7.165747546157988e-08 7.1447384963711125 -0.994717621635514 down SLLPVKPVEIEIETPEQAK(ub)TR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLLPVKPVEIEIETPEQAKTR 21 2 Q01831 Q01831 XPC DNA repair protein complementing XP-C cells 1 41671400.0 12850900.0 16886500.0 11934000.0 True False 16635743.379110105 15946751.430573506 9762134.453180596 1.0 0.9585836392858895 0.5868168455543225 23.987782999647422 -6.92801964389886 0.7628762718714974 1.006088369597584 0.5142075004432788 0.9961344082213085 0.011551002997073552 0.09367942726268008 0.0828151733524452 0.010402083890538363 0.034012213069485736 1.1802672488927684e-07 6.92801964389886 -0.4918808691543052 SLLRPHFLNTPDK(ub)SPGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLLRPHFLNTPDKSPGDR 18 2 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;Q9Y2X0-4;Q9Y2X0-5;U3KQ43;B9TWZ6;K7EKS6;U3KQB4;A0A0J9YXA0;A0A0J9YXE6;A0A0J9YYC6;A0A0J9YXK9;A0A0J9YXL6;A0A0J9YW49;B9TX03;A0A0J9YY02;A0A0J9YXE7 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 6946600.0 1311700.0 3246600.0 2388300.0 True False 1719651.402520869 2762219.9351476827 2141181.62619129 1.0 1.6062673697113805 1.2451253917232832 20.713684709353046 -10.274978565886853 4.9929869924885155 0.9998978878623385 1.4256963807175513 0.6494431626761621 0.14743559512913942 0.00016762759293764758 2.4340927644822347e-05 0.14278794401265194 0.04758463371433587 5.309106460790989e-11 10.274978565886853 0.4257984928552129 SLLRPHFLNTPDK(ub)SPGDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLRPHFLNTPDKSPGDR 18 2 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;Q9Y2X0-4;Q9Y2X0-5;U3KQ43;B9TWZ6;K7EKS6;U3KQB4;A0A0J9YXA0;A0A0J9YXE6;A0A0J9YYC6;A0A0J9YXK9;A0A0J9YXL6;A0A0J9YW49;B9TX03;A0A0J9YY02;A0A0J9YXE7 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 8242400.0 1937200.0 1226400.0 5078800.0 True False 1875704.6463696698 1716107.915591512 3748509.9192659217 1.0 0.9149137199787563 1.9984542483919152 20.839001244318254 -6.887918907912344 1.034637079227234 0.9388421935703138 2.0879283394811665 0.9795316751952328 0.0703833333615483 0.12084699750895667 0.23185208751199182 0.05197018161672398 0.12862623049894495 1.2944375181134472e-07 6.887918907912344 1.1490861459108528 SLLRPHFLNTPDK(ub)SPGDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLLRPHFLNTPDKSPGDR 18 2 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;Q9Y2X0-4;Q9Y2X0-5;U3KQ43;B9TWZ6;K7EKS6;U3KQB4;A0A0J9YXA0;A0A0J9YXE6;A0A0J9YYC6;A0A0J9YXK9;A0A0J9YXL6;A0A0J9YW49;B9TX03;A0A0J9YY02;A0A0J9YXE7 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 21776600.0 4417600.0 7204000.0 10155000.0 True False 6701822.169820084 5918389.91489109 8147859.798905388 1.0 0.883101605044524 1.2157678303666664 22.67612197503659 -6.811759974233092 1.4071891077807996 0.9364222643602169 1.221820910206557 0.8643488892408236 0.050751158524578184 0.20441646816955394 0.7974605704804882 0.02835622113402126 0.06554096332492317 1.5425527550781835e-07 6.811759974233092 0.28539864584634 SLLRPHFLNTPDK(ub)SPGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLLRPHFLNTPDKSPGDR 18 2 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;Q9Y2X0-4;Q9Y2X0-5;U3KQ43;B9TWZ6;K7EKS6;U3KQB4;A0A0J9YXA0;A0A0J9YXE6;A0A0J9YYC6;A0A0J9YXK9;A0A0J9YXL6;A0A0J9YW49;B9TX03;A0A0J9YY02;A0A0J9YXE7 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 8251300.0 1311700.0 1470300.0 5469300.0 True False 1796670.9373596506 1405337.2843680896 4177563.9837692827 1.0 0.7821895791520641 2.3251692321068775 20.776894770875938 -6.871151837379769 1.1280604702438908 0.8759275173668818 2.4175042024795985 0.9658154910997236 0.12606800515300665 0.1357513087259272 0.32216985483975585 0.08667372387656666 0.20561238825487224 1.3453898986397067e-07 6.871151837379769 1.5415766851127168 up SLLRPHFLNTPDK(ub)SPGDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLLRPHFLNTPDKSPGDR 18 2 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;Q9Y2X0-4;Q9Y2X0-5;U3KQ43;B9TWZ6;K7EKS6;U3KQB4;A0A0J9YXA0;A0A0J9YXE6;A0A0J9YYC6;A0A0J9YXK9;A0A0J9YXL6;A0A0J9YW49;B9TX03;A0A0J9YY02;A0A0J9YXE7 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 6885200.0 1937200.0 2074300.0 2873700.0 True False 1610867.6325111005 2063125.3341836852 3474577.383512443 1.0 1.2807541057657128 2.156960207894983 20.61940651975253 -6.950559338991923 0.5526710586312458 0.9880697907389023 2.490996279763605 0.9992444352671687 0.013544154069346271 0.08326196105533851 0.035039150653069374 0.014650563297881381 0.07272607552745933 1.1205743081592812e-07 6.950559338991923 1.502926489024703 up SLLSAEEAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLLSAEEAAK 10 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 12573400.0 1532200.0 4403900.0 6637300.0 False True 2008729.0378459047 3746855.2862677453 5950535.865477309 1.0 1.8652865646258343 2.9623387492115256 20.93785153801431 -6.967900792161773 0.3041817384655216 0.8189466924435802 4.043259481096972 0.9999610653452315 0.0050104134984223945 0.07698994200050838 0.011455617050591001 0.017833526957729797 0.09796262372398304 1.0767111434996408e-07 6.967900792161773 3.2243127886533918 SLLSAEEAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLSAEEAAK 10 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 9341600.0 3761900.0 1329600.0 4250100.0 False True 3642480.54365995 1860516.2137724033 3136871.309733024 1.0 0.5107827458435684 0.8611909582312025 21.79648983546701 -10.04864537023229 5.590383376971366 1.0000015083798597 0.6859868520372588 0.5170818980256944 0.14305355367220188 2.6894087576137007e-06 4.5781358691472e-07 0.13851167435938785 0.04617033591561988 8.940352238188025e-11 10.04864537023229 -0.31401465634260084 SLLSAEEAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLLSAEEAAK 10 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 11131500.0 1532200.0 4556800.0 5042500.0 False True 2098695.7461480936 4355465.508677497 3851565.353547357 1.0 2.0753201204469183 1.8352185449541445 21.001061599537202 -10.691027747845295 7.535040981456413 0.9955124792954604 1.9552693327003832 0.9547628610046797 0.09802105773260515 0.007379398052066113 0.0003025898152217714 0.09477892617992185 0.03163616034800128 2.0369119316294242e-11 10.691027747845295 0.9597568534049228 SLLSILQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLLSILQR 8 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 7507900.0 1617500.0 2004800.0 3885600.0 False True 2120558.1638922812 1705691.6546491913 3483555.3853070773 1.0 0.8043597594693639 1.6427539902574597 21.01601262387283 -6.845230545328282 1.257819161983306 0.8958801743048902 1.6733218712500502 0.9330848297350518 0.09264090131620573 0.16277998799983912 0.4979814576034563 0.05769564057675064 0.13317167001963554 1.4281356311127247e-07 6.845230545328282 0.77744169694516 SLLSILQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLSILQR 8 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 5760800.0 1450800.0 1407300.0 2902700.0 False True 1404745.1481277684 1969242.2289725475 2142395.7908665813 1.0 1.4018501730346857 1.5251135009947867 20.421876986686907 -12.073276503028836 0.19552656966420934 6.744350259649926e-09 1.6176501916778954 0.9994185180396866 0.005406525873289606 5.451863841591983 0.12418632350403658 2.278717877756159 0.0806330702296482 8.447408512776307e-13 12.073276503028836 1.6176501849335452 SLLSILQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLLSILQR 8 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 9005200.0 1617500.0 3637700.0 3750000.0 False True 2215533.46129392 3476974.385734748 2864327.2336742915 1.0 1.569362163324818 1.292838624970016 21.07922268539572 -10.008809744529321 4.347981764961977 0.9999796234779954 1.4311003939882454 0.764186775603916 0.11289026213173493 25957295.83893528 42406585.37968319 7228.453648307963 0.041313605223268664 9.799191738066763e-11 10.008809744529321 0.43112077051025 SLLSILQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLLSILQR 8 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 3919800.0 1450800.0 1072200.0 1396800.0 False True 1206404.4813375496 1066423.8457849624 1688864.4219265024 1.0 0.8839687370877555 1.3999155739657447 20.202282262121184 -6.847640085068594 1.2464113619771908 0.9381849395461664 1.4196228449032327 0.9368050840892542 0.05555806396393214 0.16006938332154264 0.47972120451517697 0.03489969075325935 0.08064827578536293 1.4202340314177125e-07 6.847640085068594 0.4814379053570662 SLLSNDLK(ub)LNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLSNDLKLNLK 12 1 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18;H3BVE6 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 5466000.0 1313100.0 2260600.0 1892300.0 True False 1271416.3592545995 3163269.3688732623 1396649.862216844 1.0 2.487988569478381 1.0984992068496475 20.27800512607683 -6.6299605089439115 2.080697195381798 1.9803017893547146 1.104083830908549 0.1174751689867991 0.6382652727675359 0.5589673054732086 4.611601363292597 0.2509052044766858 0.7070198999046996 2.344441989294395e-07 6.6299605089439115 -0.8762179584461656 SLLSNDLK(ub)LNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLLSNDLKLNLK 12 1 Q16666;Q16666-2;Q16666-3;Q16666-6;X6RHM1;H3BM18;H3BVE6 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 4810200.0 1313100.0 2151400.0 1345700.0 True False 1091900.830193229 2139809.981180538 1627079.6481862057 1.0 1.9597109206354069 1.490135004200215 20.058410401511107 -10.233257245273771 4.890789163495232 0.9998710816678414 1.7249229624188356 0.7606329720075515 0.19170356513120806 0.000269526757720001 4.225421762310383e-05 0.1856487867433439 0.061872059596308565 5.844437985088294e-11 10.233257245273771 0.7250518807509941 SLLSNVSQWDTFK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLLSNVSQWDTFK 13 0 Q0VDD8-4;Q0VDD8;A0A1W2PR53;H7BXS7 Q0VDD8-4 DNAH14 Dynein heavy chain 14, axonemal 1 53468000.0 13630000.0 13109000.0 26729000.0 True False 17869061.993107762 11153188.29848179 23963339.48267262 1.0 0.6241619343412464 1.3410518969555016 24.09096056868553 -6.764234400320488 1.5963549692082457 0.7828465265336269 1.3442499666330925 0.7080780861926015 0.15819056762363023 0.27586122513768946 1.3863688535366767 0.07815014981954609 0.1870436712050443 1.7209394873194354e-07 6.764234400320488 0.5614034400994656 SLLSNVSQWDTFK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLSNVSQWDTFK 13 0 Q0VDD8-4;Q0VDD8;A0A1W2PR53;H7BXS7 Q0VDD8-4 DNAH14 Dynein heavy chain 14, axonemal 1 40657800.0 11639000.0 9427800.0 19591000.0 True False 11269526.315866496 13192369.705327515 14459529.382597974 1.0 1.1706232662817269 1.2830645208432794 23.425923541202398 -9.092108076171469 0.04462143174887655 3.397427231150766e-20 2.216618251945867 0.9999983153797308 0.00015093153848308108 0.5654621316601537 0.014958266727304092 0.40001066732934004 0.3381670659764877 8.088945770081461e-10 9.092108076171469 2.216618251945867 SLLSNVSQWDTFK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLLSNVSQWDTFK 13 0 Q0VDD8-4;Q0VDD8;A0A1W2PR53;H7BXS7 Q0VDD8-4 DNAH14 Dynein heavy chain 14, axonemal 1 36724000.0 13630000.0 12069000.0 11025000.0 True False 18669379.33690024 11535751.673154097 8421122.067002408 1.0 0.6178969029973884 0.4510659896635109 24.154170630208423 -13.999999999999998 0.11269509824130594 2.835741233552378 0.1565617565808779 0.9997294014672768 0.0037797464390934145 11.997498143660728 0.10229924809470924 4.987270298175383 0.2614349400967129 1.0000000000000041e-14 13.999999999999998 -2.6791794769715 SLLSNVSQWDTFK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLLSNVSQWDTFK 13 0 Q0VDD8-4;Q0VDD8;A0A1W2PR53;H7BXS7 Q0VDD8-4 DNAH14 Dynein heavy chain 14, axonemal 1 29015500.0 11639000.0 11534000.0 5842500.0 True False 9678344.19512528 11471864.052680263 7064139.737332178 1.0 1.1853126755357937 0.7298913527884444 23.206328816636674 -6.7962535287022385 1.4713447928634313 1.1027360053994337 0.7241839291510244 0.8209263128152514 0.07913134699441164 0.22615232510524477 0.9669361640874014 0.0423195382188064 0.09864472640950504 1.598624524871164e-07 6.7962535287022385 -0.37855207624840936 SLLSQMLHYDPNKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLLSQMLHYDPNKR 14 1 E7ESI2;G3V5T9;P24941-2;P24941 E7ESI2 CDK2 Cyclin-dependent kinase 2 0 30008200.0 9346600.0 8986200.0 11675400.0 False True 12253483.112603163 7645493.987933256 10467341.606345013 1.0 0.6239445484745134 0.8542339765889881 23.54668856486889 -10.349831444666185 5.822501765713831 1.0000427449084142 0.7390892625317502 0.6311992277422356 0.0940152653396372 5.2175366805894314e-05 5.8260827646164e-06 0.09104477237175046 0.03034329641247353 4.4685698950621856e-11 10.349831444666185 -0.26095348237666394 SLLSQMLHYDPNKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLSQMLHYDPNKR 14 1 E7ESI2;G3V5T9;P24941-2;P24941 E7ESI2 CDK2 Cyclin-dependent kinase 2 0 24724500.0 3475100.0 7056900.0 14192500.0 False True 3364784.8526735706 9874756.971247332 10475058.484126478 1.0 2.9347365146990323 3.113143616241398 21.682082829908932 -10.349873205739682 0.4969707294028659 6.41901155066214e-17 3.107525873987469 0.9995102446943528 0.02117594133575624 1.7066481595769245 0.2338921953644539 2.3204271271915973 0.036390579127003816 4.468140225076251e-11 10.349873205739682 3.107525873987469 SLLSQMLHYDPNKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLLSQMLHYDPNKR 14 1 E7ESI2;G3V5T9;P24941-2;P24941 E7ESI2 CDK2 Cyclin-dependent kinase 2 0 10407700.0 1035400.0 3967000.0 5405300.0 False True 1570777.4978793291 3259057.8556875316 4336940.085772852 1.0 2.0748055406239976 2.7610149060755305 20.58304740530945 -8.464552933819913 0.17413566759142132 4.408237392058353e-13 3.774214450902538 0.9998251009367654 0.009584673531408607 0.1431780308634127 0.04346563929181836 0.43416962714299767 0.3803573965387954 3.431208160958086e-09 8.464552933819913 3.774214450902097 SLLSQMLHYDPNKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLLSQMLHYDPNKR 14 1 E7ESI2;G3V5T9;P24941-2;P24941 E7ESI2 CDK2 Cyclin-dependent kinase 2 0 43810400.0 9346600.0 17189800.0 17274000.0 False True 12802290.60236771 16430297.796933018 13194236.969197238 1.0 1.2833873489713106 1.0306153311937036 23.609898626391782 -10.556606568973928 2.904406782241016 0.9919126934113542 1.1570013400534827 0.33966547421532545 0.10319374671237735 21474818.96789891 23682371.60881837 1356584.4552696 0.03678262098332752 2.7758336170083287e-11 10.556606568973928 0.1650886466421284 SLLSQMLHYDPNKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLLSQMLHYDPNKR 14 1 E7ESI2;G3V5T9;P24941-2;P24941 E7ESI2 CDK2 Cyclin-dependent kinase 2 0 15987600.0 3475100.0 5500900.0 7011600.0 False True 2889699.6230328963 5471265.559856836 8477693.142024513 1.0 1.893368264385364 2.933762760133081 21.46248810534321 -6.969121964668462 0.2783584013351601 0.7662185564110462 4.092544649306879 0.9999747015492951 0.003974587780032769 0.07658862499339027 0.010045700469266988 0.019400898644606153 0.09569462357434924 1.0736878419167148e-07 6.969121964668462 3.3263260928958323 SLLSQMLHYDPNKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLLSQMLHYDPNKR 14 1 E7ESI2;G3V5T9;P24941-2;P24941 E7ESI2 CDK2 Cyclin-dependent kinase 2 0 17511400.0 1035400.0 8584200.0 7891800.0 False True 1340345.710785287 8106481.723881744 6455573.376706101 1.0 6.048052870727125 4.816349487121411 20.3541737274019 -9.868577618726038 5.896584441426335 0.9999990557394314 5.432201178929154 0.9452503378175998 0.502840800732939 6.240038621651077e-06 1.2008417037857194e-06 0.48687362774724163 0.16229117058348647 1.3533881864817526e-10 9.868577618726038 4.432202123189723 SLLVIPNTLAVNAAQDSTDLVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLLVIPNTLAVNAAQDSTDLVAK 23 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 10220600.0 4896000.0 3457800.0 1866800.0 False True 6418703.41293145 2941909.71839883 1673641.4436100605 1.0 0.4583339545603412 0.2607444737574658 22.613850469685612 -13.999999999999996 0.14024505711021754 3.5880110659989373 0.01693758356989026 0.9996019585758523 0.0062348055391031375 11.934271006675639 0.11735015640497327 8.451272637704676 0.2179965955713457 1.0000000000000082e-14 13.999999999999996 -3.571073482429047 SLLVIPNTLAVNAAQDSTDLVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLVIPNTLAVNAAQDSTDLVAK 23 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 39321000.0 15389000.0 10133000.0 13799000.0 False True 14900484.618512714 14179159.742896933 10184627.938873451 1.0 0.9515905090281701 0.6835098454596455 23.82885591740604 -6.937554706095673 0.6819331222300059 1.0031742455001817 0.6161371245230063 0.9978257448544644 0.006490499231809931 0.088900172454934 0.059823913279015956 0.006206562239439732 0.02333263184373562 1.1546365312294461e-07 6.937554706095673 -0.38703712097717546 SLLVIPNTLAVNAAQDSTDLVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLLVIPNTLAVNAAQDSTDLVAK 23 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 182706000.0 20718000.0 120760000.0 41228000.0 False True 31430720.68868446 99209434.4978136 33079267.72912564 1.0 3.1564479695029872 1.0524501826340458 24.905672016910426 -6.640448361286341 2.042533082893576 2.4097320098854365 1.061170996051844 0.15632609660503693 0.9225816354860987 0.5323319315818041 4.244983968445198 0.36772917811958 1.0217884478227026 2.288503804295923e-07 6.640448361286341 -1.3485610138335924 SLLVIPNTLAVNAAQDSTDLVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLLVIPNTLAVNAAQDSTDLVAK 23 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 12246000.0 4896000.0 1614000.0 5736000.0 False True 6706183.5094250655 1542688.1432157364 4381274.936628191 1.0 0.23003965534906665 0.6533186767810066 22.677060531208504 -10.610143296853245 5.7610763437196 1.0031687618738663 0.44167916607543156 0.6987781839255895 0.17280293688880655 0.007060485830770475 0.00047778843677773067 0.1679674806428273 0.05577190806217321 2.453899110234057e-11 10.610143296853245 -0.5614895957984347 SLLVIPNTLAVNAAQDSTDLVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLLVIPNTLAVNAAQDSTDLVAK 23 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 30033900.0 15389000.0 6346600.0 8298300.0 False True 12796635.348293057 6312409.606098527 10033436.162995897 1.0 0.49328666749424405 0.7840683031054922 23.609261192840318 -10.202829942366549 5.645774807879951 1.0000114091264922 0.6386774852998552 0.6730646162916747 0.11871110563663202 1.704840667281897e-05 2.407094630126611e-06 0.11494516062902652 0.03831384459503758 6.268592772694004e-11 10.202829942366549 -0.361333923826637 SLLVIPNTLAVNAAQDSTDLVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLLVIPNTLAVNAAQDSTDLVAK 23 0 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 77229000.0 20718000.0 27736000.0 28775000.0 False True 26819859.41283517 26192467.218096536 23538245.25643297 1.0 0.976607178095856 0.8776423803760984 24.676798339002875 -6.943592561147347 0.6252848061636453 1.0010802801453784 0.8478788982528537 0.9985972016082455 0.001986292874474758 0.08616608740839715 0.047435310371084144 0.0019908145141211238 0.00839233848561538 1.1386950660254907e-07 6.943592561147347 -0.15320138189252475 SLLVQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLLVQTK 7 0 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 0 19393300.0 5553400.0 6651800.0 7188100.0 False True 7280561.1792021 5659377.368513323 6444344.365123984 1.0 0.7773270808684493 0.8851439066995438 22.795618225688955 -10.110332562042114 4.573828201394881 1.0000140089752694 0.831235493780168 0.7656345237845243 0.04401603484468149 46369148.197707124 0.2071807631938344 7027.802359361575 0.01610821935339062 7.756529310641685e-11 10.110332562042114 -0.16877851519510134 SLLVQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLVQTK 7 0 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 0 15183800.0 5564400.0 3373200.0 6246200.0 False True 5387761.167798573 4720136.351005616 4610132.838016621 1.0 0.8760849273009353 0.8556676315888573 22.361254468812312 -13.999999998812806 0.25374496826980164 1.8783020008702604 0.8477457263595071 0.9995498455184313 0.0013530621412673396 14.149590752257364 0.15939492692286103 6.348630634390156 0.00923025542504239 1.000000002733616e-14 13.999999998812806 -1.0305562745107535 SLLVQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLLVQTK 7 0 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 0 22092800.0 5553400.0 6637800.0 9901600.0 False True 7606642.05499206 6344520.047730751 7563046.009853158 1.0 0.8340763245941082 0.9942686871784258 22.858828287211846 -10.648821650768738 7.84860461771286 1.0001504410719597 0.9141725058886426 0.27680014618566495 0.06539825817041495 0.00017245843659247976 7.716485162991318e-06 0.06343212389304036 0.021107197063749188 2.2448035951760136e-11 10.648821650768738 -0.08597793518331709 SLLVQTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLLVQTK 7 0 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 0 11056700.0 5564400.0 3759500.0 1732800.0 False True 4627045.144716484 3739246.8272976736 2095120.46843803 1.0 0.8081284513870441 0.4527987955402596 22.14165974424659 -6.961521039529388 0.4134398077962354 1.0168607169310016 0.23080573772022023 0.9998225153631669 0.0030200603280533867 0.07916220078564437 0.01915632378314492 0.004580833879915728 0.029635186987223956 1.0926446923994258e-07 6.961521039529388 -0.7860549792107814 down SLLVQTK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLLVQTKR 8 1 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 1 4854300.0 1474700.0 1638000.0 1741600.0 True False 1933345.9810151153 1393616.7848739934 1561395.9386068552 1.0 0.7208315524271895 0.8076133056055671 20.88266840678535 -10.371783008802224 8.244514054807514 1.0000015601224121 0.7642224290163784 0.9077667702823019 0.03542850237852954 1.015976527987863e-06 7.737734276799068e-08 0.034303726850163724 0.011434499974426224 4.248317741713526e-11 10.371783008802224 -0.23577913110603377 SLLVQTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLLVQTKR 8 1 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 1 9670700.0 1781600.0 3892000.0 3997100.0 True False 1725044.083198533 5446095.896511877 2950139.5995703368 1.0 3.1570763608625376 1.710182150302074 20.718201799504417 -10.415401819669718 6.169961404112868 0.9996456049410958 2.4336292555823 0.5669116546359083 0.5906920879433707 0.0028802514840768623 0.00027289926077347346 0.5720619054973747 0.19064505161176332 3.8423611306759864e-11 10.415401819669718 1.4339836506412043 SLLVQTK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLLVQTKR 8 1 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 1 5330900.0 1474700.0 1815600.0 2040600.0 True False 2019936.4422690235 1735380.7886136873 1558652.3074761997 1.0 0.8591264320496684 0.7716343320809358 20.94587846830824 SLLVQTK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLLVQTKR 8 1 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 1 8170000.0 1781600.0 4354400.0 2034000.0 True False 1481479.3382623228 4330941.982919274 2459299.9958465826 1.0 2.9233900676597906 1.660029898716764 20.498607074938693 -10.043953843292025 4.804851318847526 0.999967078664866 2.2917099832114234 0.5822619681281669 0.5157646292907815 178512263.49499813 8.328322101545009 65023.30117696705 0.1765599511291476 9.03745518464116e-11 10.043953843292025 1.2917429045465574 SLLVQTK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLLVQTKR 8 1 P39023;G5E9G0 P39023 RPL3 60S ribosomal protein L3 1 6978310.0 1501000.0 873210.0 4604100.0 True False 1943074.08913339 824615.0958867187 3766201.042055364 1.0 0.42438685199826665 1.938269396477356 20.88990948104902 -6.803663996287322 1.4407726222555373 0.6838555300687524 1.961134687156293 0.8426645308086584 0.247482437610034 0.21558868841804887 0.8830804051099757 0.13510243549065817 0.3135428823301908 1.571578228248998e-07 6.803663996287322 1.2772791570875404 SLMDNASSSFEFAK(ub)ELIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLMDNASSSFEFAKELIR 18 1 A0AVF1-3;A0AVF1;Q96CU4;A0AVF1-2;B7Z6R6 A0AVF1-3 TTC26 Intraflagellar transport protein 56 1 5874000.0 0.0 0.0 5874000.0 True False 0.0 0.0 4713001.325334346 0.0 SLMDSDDDALLK(ub)SQHINTLGQFWTTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLMDSDDDALLKSQHINTLGQFWTTK 26 1 O75911;Q5SUY4 O75911 DHRS3 Short-chain dehydrogenase/reductase 3 1 22626300.0 8232200.0 6365800.0 8028300.0 True False 7970873.317078458 8907697.137208458 5925447.3861626 1.0 1.117530888130257 0.7433874746781746 22.926306368972103 -6.822273595698591 1.3620682923755114 1.0632059273917347 0.7348181088835862 0.8895241693937391 0.051924797630022244 0.19054069633571386 0.6939826179586324 0.029952944984371187 0.06899636277391548 1.5056582367208207e-07 6.822273595698591 -0.32838781850814847 SLMDSDDDALLK(ub)SQHINTLGQFWTTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLMDSDDDALLKSQHINTLGQFWTTK 26 1 O75911;Q5SUY4 O75911 DHRS3 Short-chain dehydrogenase/reductase 3 1 60816000.0 15884000.0 20484000.0 24448000.0 True False 24097189.275946725 16828470.157777525 19615842.084060926 1.0 0.6983582178430796 0.8140302945472989 24.522361542860352 -10.121296508229266 5.52667286476398 1.0000033941979702 0.7561942563940695 0.8555618604984075 0.04722292756909042 1.9749909730426467e-06 3.1400455474005404e-07 0.04572403997345125 0.015241134336159904 7.563163547402095e-11 10.121296508229266 -0.2438091378039008 SLMDSDDDALLK(ub)SQHINTLGQFWTTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLMDSDDDALLKSQHINTLGQFWTTK 26 1 O75911;Q5SUY4 O75911 DHRS3 Short-chain dehydrogenase/reductase 3 1 18993700.0 8232200.0 7417100.0 3344400.0 True False 6845439.048295414 7377142.610120927 4043698.5772415414 1.0 1.0776726749116132 0.5907142768656255 22.70671164440638 -6.8660707822745914 1.154741034011057 1.0430370105724962 0.5642540802716222 0.9605984466184851 0.04240189331741243 0.14067455340667023 0.3530657108957447 0.02856132159008678 0.06719280286518343 1.361222809283552e-07 6.8660707822745914 -0.47878293030087404 SLMDSDDDALLK(ub)SQHINTLGQFWTTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLMDSDDDALLKSQHINTLGQFWTTK 26 1 O75911;Q5SUY4 O75911 DHRS3 Short-chain dehydrogenase/reductase 3 1 49955000.0 15884000.0 17210000.0 16861000.0 True False 20562151.120449565 16252248.371194132 13792471.008469744 1.0 0.7903963099965193 0.6707698493059314 24.2934878649528 -13.999999999992204 0.06407835983401455 2.278978342574831 0.1781913485127271 0.9999430668971937 0.0010266906798138253 12.421885109529072 0.06628027544906287 2.4711788339004532 0.4582690767068206 1.000000000017952e-14 13.999999999992204 -2.100786994062104 SLMK(ub)ILSEVTPDQSKPEN ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLMKILSEVTPDQSKPEN 18 2 O43482 O43482 OIP5 Protein Mis18-beta 1 14523200.0 4205400.0 4992000.0 5325800.0 True False 4071901.878919577 6985331.632936087 3930813.2094247537 1.0 1.7154960607227472 0.9653506705981187 21.95727136637096 -6.656886148492588 1.9838584508408998 1.4617323922466776 0.9684885921995164 0.22246512414327035 0.30487036558468056 0.4918848374327946 3.7181096430166427 0.1242976713156952 0.33787646145958583 2.2035040420618764e-07 6.656886148492588 -0.4932438000471612 SLMPYFLLTQAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLMPYFLLTQAVR 13 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 59690000.0 16445000.0 21105000.0 22140000.0 False True 24948267.29054038 17338647.855882365 17764019.295693286 1.0 0.6949840505539497 0.712034190143091 24.572436285058647 -10.138858554565417 4.7280737725290045 1.000025146092194 0.703509120345807 0.9975258903658751 0.00696069034877598 1737588.1452555677 3726075.7887565573 289.8897564295102 0.0023828297858466017 7.263424815074154e-11 10.138858554565417 -0.296516025746387 SLMPYFLLTQAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SLMPYFLLTQAVR 13 0 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 0 91128800.0 20490800.0 42652700.0 27985300.0 False True 26525744.534053605 40279039.75026342 22892262.553426754 1.0 1.518488564894132 0.8630205468516743 24.660889909998595 -6.695869785350028 1.8453508820528144 1.323261417548149 0.8651028235800193 0.3979993907733941 0.21903174608064435 0.4042404700995647 2.673191984342311 0.09479143547686944 0.24505159117907893 2.0143281159564922e-07 6.695869785350028 -0.45815859396812963 SLNILTAFQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLNILTAFQK 10 0 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 305105000.0 102150000.0 107330000.0 95625000.0 False True 133919639.22200711 91316782.36906315 85730642.29977061 1.0 0.6818774520268943 0.640164824202143 26.99679230550091 -13.999999999999998 0.2863738919008289 3.686027037077046 0.6283769176704143 0.9996193539808589 0.003135295236294385 15.753731096735658 0.16962930828940762 24.876131038995446 0.016016255797536117 1.0000000000000041e-14 13.999999999999998 -3.057650119406632 SLNILTAFQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLNILTAFQK 10 0 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 242604000.0 124190000.0 40562000.0 77852000.0 False True 120247656.42816898 56758618.1280356 57460225.69006274 1.0 0.4720143395222082 0.47784902755578545 26.84143353590165 -9.961346909222359 6.093320698007231 1.000000246246139 0.4749316835394094 0.9999073965321644 0.0023820014153377654 7.966251822180414e-09 1.3564669079098137e-09 0.0023063640011361125 0.0007687876509852863 1.0930828759630243e-10 9.961346909222359 -0.5250685627067296 SLNILTAFQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLNILTAFQK 10 0 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 258756000.0 66815000.0 99485000.0 92456000.0 False True 101363239.83079709 81731124.47014718 74182031.07509562 1.0 0.8063191804699488 0.7318435282744087 26.59495930168479 -13.999999999999998 0.13235580509172562 1.920904141080196 0.6306000586466 0.999635082511606 0.0021590400963459174 11.9338229800405 0.11336195041268478 2.853249251343642 0.09012545474007842 1.0000000000000041e-14 13.999999999999998 -1.2903040824335958 SLNILTAFQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLNILTAFQK 10 0 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 263978000.0 102150000.0 73332000.0 88496000.0 False True 139917615.49995294 70091949.76350464 67595067.43233061 1.0 0.500951574346464 0.48310619925018194 27.060002367023802 SLNILTAFQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLNILTAFQK 10 0 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 210584000.0 124190000.0 38022000.0 48372000.0 False True 103269487.54984167 37817167.939223945 58486361.553142026 1.0 0.36619885347036296 0.5663469717995293 26.621838811335927 -10.18580245648378 5.10346485722047 1.000037332787648 0.46627291263453075 0.9045932419465735 0.08171012714896556 3.471070388751057e-05 5.537670284001217e-06 0.0791210088182623 0.026371830138484025 6.51924861665207e-11 10.18580245648378 -0.5337644201531172 SLNILTAFQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLNILTAFQK 10 0 P30040;F8VY02 P30040 ERP29 Endoplasmic reticulum resident protein 29 0 246640000.0 66815000.0 100020000.0 79805000.0 False True 86493334.62055138 94453799.07535379 65281308.86844954 1.0 1.0920355827385448 0.7547553710911994 26.366085623777238 -6.833997885837841 1.3099991881753315 1.0490577662028246 0.7449184870549717 0.9136274238556399 0.04183573914743041 0.1759294645709093 0.5890394948570664 0.025063883486620423 0.05768138268312426 1.465554975316254e-07 6.833997885837841 -0.304139279147853 SLNLGGTHLK(ub)EEDVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLNLGGTHLKEEDVR 15 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 252862000.0 74485000.0 83392000.0 94985000.0 True False 97650556.31376602 70950238.65947011 85156863.36045721 1.0 0.7265728054993998 0.8720571246602561 26.541124927359192 -10.13300909570264 4.696169598807758 1.000017020746499 0.7993149650775295 0.7172819367497965 0.05939372459459819 82956567.67143103 1.9579363920782453 15268.266595697953 0.020332051708010692 7.361916788076536e-11 10.13300909570264 -0.20070205566896937 SLNLGGTHLK(ub)EEDVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLNLGGTHLKEEDVR 15 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 260033000.0 75482000.0 68547000.0 116004000.0 True False 73085865.22675794 95918174.56788258 85619072.35459627 1.0 1.3124039001287673 1.1714860607992053 26.123089080798945 -10.15516890574163 4.188350575104062 0.9999347185196302 1.2419449803719727 0.7971779132415541 0.05752946716029913 8151644.723604878 9882334.493418535 4158.862393067014 0.019693865324604726 6.99569866484918e-11 10.15516890574163 0.24201026185234242 SLNLGGTHLK(ub)EEDVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLNLGGTHLKEEDVR 15 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 504491000.0 131982000.0 110220000.0 262289000.0 True False 200226343.1766558 90550379.84720938 210447464.1846475 1.0 0.4522400919409418 1.051047833396097 27.57705655679978 -6.666185677197368 1.952292850653793 0.649203240590249 1.0485199959859417 0.26177430473491625 0.23288713420839718 0.4698689970097907 3.4492966475851876 0.09619335871819534 0.2581583922109055 2.1568220895785972e-07 6.666185677197368 0.39931675539569267 SLNLGGTHLK(ub)EEDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLNLGGTHLKEEDVR 15 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 268921000.0 74485000.0 92166000.0 102270000.0 True False 102024117.381439 88093801.36779529 78115932.31676523 1.0 0.8634605584328434 0.7656614369395827 26.604334988882083 -6.974735916981338 0.08988693936257972 1.2870847129072351 0.3395707740876592 0.9999998333779847 3.880148444898397e-05 0.074793544462804 0.0026219239632587995 0.010145278485937057 0.017350473562516004 1.059898025297765e-07 6.974735916981338 -0.9475139388195759 SLNLGGTHLK(ub)EEDVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLNLGGTHLKEEDVR 15 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 270178000.0 75482000.0 115397000.0 79299000.0 True False 62766627.41957616 114775333.45648889 95880054.26285048 1.0 1.8286044379802353 1.5275642201057091 25.90349435623322 -10.190625794906532 4.894574380701206 0.999925913106025 1.6780843290444916 0.87121423781712 0.12289915431339313 9.936971735910212e-05 1.6432075740364126e-05 0.11900950997378396 0.03966553149248049 6.44724546113375e-11 10.190625794906532 0.6781584159384666 SLNLGGTHLK(ub)EEDVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLNLGGTHLKEEDVR 15 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 402422000.0 131982000.0 100584000.0 169856000.0 True False 170853300.7541661 94986411.97955786 138943950.86973715 1.0 0.5559530401828757 0.8132353911596826 27.348182878892228 -10.215381373900447 5.589348348332017 1.0000129826345387 0.6845942156712643 0.6670902362447771 0.10503507995285834 1.699325425327822e-05 2.385605547489571e-06 0.10170396174698997 0.033899926285407646 6.09001869888951e-11 10.215381373900447 -0.3154187669632744 SLNNFCSQIGDDRPISYCHFSPNSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLNNFCSQIGDDRPISYCHFSPNSK 25 1 O43172-2;O43172 O43172-2 PRPF4 U4/U6 small nuclear ribonucleoprotein Prp4 0 10018500.0 2694600.0 3822900.0 3501000.0 False True 3532646.694543519 3252538.2215474863 3138750.1039633662 1.0 0.920708608243025 0.8884981645097539 21.752318039606326 -13.999999999999998 0.12399099611026708 1.3770791185707183 0.839747905350965 0.9996735904490881 0.0008464744189145394 11.950211132198909 0.10886333987159055 1.104929451247879 0.04328221415244273 1.0000000000000041e-14 13.999999999999998 -0.5373312132197533 SLNWEEMEK(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLNWEEMEKSR 11 1 K7ENR6;Q969U7-2;Q969U7;V9GZ55 K7ENR6 PSMG2 Proteasome assembly chaperone 2 1 5321800.0 1031800.0 2446600.0 1843400.0 True False 1352699.7919654143 2081576.8167721059 1652662.651141411 1.0 1.5388313276426728 1.2217512421881602 20.36741026325827 -10.278510327377896 5.080739438562953 0.9999178941059751 1.3802912849154116 0.6572917118065464 0.12944740282735218 0.00012042873259199117 1.7101738356042442e-05 0.1253638538555081 0.041778969613285775 5.2661069211842653e-11 10.278510327377896 0.38037339080943655 SLNWEEMEK(ub)SR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLNWEEMEKSR 11 1 K7ENR6;Q969U7-2;Q969U7;V9GZ55 K7ENR6 PSMG2 Proteasome assembly chaperone 2 1 35489800.0 6107800.0 16809000.0 12573000.0 True False 9265979.13999165 13809302.62068356 10087941.039058326 1.0 1.4903230853481075 1.0887075058823645 23.143512003836037 -10.202991245331651 5.752319707889495 0.99999246610287 1.289515295615243 0.4092921424371707 0.16395887374056844 1.584219657993457e-05 2.194913753921193e-06 0.1587566256988044 0.05291749895500848 6.266264963130526e-11 10.202991245331651 0.28952282951237296 SLNWEEMEK(ub)SR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLNWEEMEKSR 11 1 K7ENR6;Q969U7-2;Q969U7;V9GZ55 K7ENR6 PSMG2 Proteasome assembly chaperone 2 1 7197000.0 1031800.0 2114900.0 4050300.0 True False 1413284.3433465646 2021456.7249609416 3093702.5585469296 1.0 1.4303255636259755 2.189016366813521 20.430620324781163 -6.962433766465458 0.39965679134916593 0.9581355994821882 2.6888936832355297 0.9998500861694594 0.006018444631223804 0.07884292195104446 0.01800106417199674 0.009762532397491001 0.06357401641864435 1.0903507673013198e-07 6.962433766465458 1.7307580837533414 up SLNWEEMEK(ub)SR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLNWEEMEKSR 11 1 K7ENR6;Q969U7-2;Q969U7;V9GZ55 K7ENR6 PSMG2 Proteasome assembly chaperone 2 1 32230800.0 6107800.0 17417000.0 8706000.0 True False 7906667.502737459 16447728.639226526 7121597.331103584 1.0 2.0802352740306795 0.9007078302758947 22.914638325928486 -6.66584385917623 1.9523267784645184 1.6919717117991884 0.9055775991986665 0.26065855717126707 0.4593071350316378 0.4707438135349767 3.4551347824097594 0.18968090721519046 0.5095014528326314 2.1585203171491942e-07 6.66584385917623 -0.7863941126005218 SLNYCGHIYTPISCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLNYCGHIYTPISCK 15 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;I3L2D8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 134566400.0 37041800.0 44021600.0 53503000.0 False True 48562158.513301514 37453748.87485282 47967022.79701581 1.0 0.7712537914597428 0.9877448668983135 25.53332921280733 -10.566002572174883 8.145839948173586 1.0000351330520856 0.8794993292040052 0.29232765012942974 0.0883821114484797 5.640850761245522e-05 3.005345081910332e-06 0.08560052467562687 0.028525203811884156 2.716423180363503e-11 10.566002572174883 -0.12053580384808038 SLNYCGHIYTPISCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLNYCGHIYTPISCK 15 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;I3L2D8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 119718000.0 27177000.0 45817000.0 46724000.0 False True 41229495.90483529 37640598.38014511 37488980.920143254 1.0 0.9129531553581454 0.9092757526474303 25.297173486338796 SLNYCGHIYTPISCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLNYCGHIYTPISCK 15 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;I3L2D8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 90804800.0 37041800.0 24749000.0 29014000.0 False True 50737154.47700601 23655507.346001413 22161490.76208687 1.0 0.46623638219053154 0.43679017852943286 25.596539274330222 -13.909794744607543 0.4133046028771287 9.999432842206565 0.4355661250848558 0.9998544595066239 0.00312262570960994 26.642356184051117 0.21332619033079428 215.46215310690818 0.007272382762535238 1.2308503554096786e-14 13.909794744607543 -9.563866717121709 SLNYCGHIYTPISCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLNYCGHIYTPISCK 15 0 Q93009;A0A669KBL1;Q93009-3;H3BND8;I3L2D8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 116905000.0 27177000.0 48124000.0 41604000.0 False True 35181162.2387596 45445857.0956041 34032498.89308908 1.0 1.2917667923300082 0.9673500455193882 25.068299808431245 -6.669737863224666 1.938465392040373 1.1862790986527028 0.9686682421088494 0.2777907251961176 0.12394435140930936 0.46173547505198653 3.344794565646924 0.05148132220688557 0.13758405447307964 2.1392529363434462e-07 6.669737863224666 -0.21761085654385337 SLNYTGEKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLNYTGEKK 9 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 2740960.0 770720.0 1286700.0 683540.0 True False 1010421.3836630977 1094729.375517316 612813.8377786693 1.0 1.0834384477776737 0.6064933380141114 19.946525645805213 -6.861745496656818 1.1767903214306996 1.0455016261241905 0.5826049815128048 0.9557327816477144 0.04375768216882214 0.14501977001569785 0.3806110225364845 0.02897904771011238 0.06778854160553067 1.3748474210295167e-07 6.861745496656818 -0.4628966446113857 SLNYTGEKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLNYTGEKK 9 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 2591450.0 1079700.0 582250.0 929500.0 True False 1045425.5144978999 814745.461393638 686036.065597714 1.0 0.7793433870656452 0.6562266331592314 19.995658844362513 -13.999999999990711 0.0689589774728154 2.2881861209111243 0.19967371775676931 0.9999279023676508 0.0012075425195919463 12.371110055852741 0.07051967082737019 2.5804198725590943 0.42122968037115555 1.0000000000213878e-14 13.999999999990711 -2.088512403154355 SLNYTGEKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLNYTGEKK 9 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 2667710.0 770720.0 1162500.0 734490.0 True False 1055676.0119248542 1111136.906126577 561018.5892963806 1.0 1.0525359045533285 0.5314306500850143 20.009735707328105 -6.882076621225473 1.0681851610073936 1.0335451933906747 0.4930027966446553 0.9753207864925268 0.03680016926542594 0.1258048995410791 0.26132430408895174 0.026487626162827935 0.06440360219092316 1.3119684120907453e-07 6.882076621225473 -0.5405423967460194 SLNYTGEKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLNYTGEKK 9 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 3740910.0 1079700.0 1939000.0 722210.0 True False 897818.3888200674 1928554.2221386344 873220.771878248 1.0 2.148044912148862 0.9726029036071023 19.77606411979679 -6.651541553880666 2.002843913702365 1.7440479411431105 0.977524289941916 0.20040874949873855 0.48981101948343114 0.5047581984663445 3.8827324474130984 0.1982092669137297 0.5426377667023274 2.230788752399418e-07 6.651541553880666 -0.7665236512011945 SLNYWCNLLGMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 SLNYWCNLLGMK 12 0 Q9HC38-2;I3L3Q4;F6TLX2;Q9HC38;Q9HC38-3 Q9HC38-2 GLOD4 Glyoxalase domain-containing protein 4 0 51799400.0 13484900.0 17967400.0 20347100.0 False True 17678834.487957377 15286733.956376659 18241777.275165115 1.0 0.8646912762710579 1.0318427545430784 24.075519829559084 -6.691320352037721 1.8614768759110014 0.9152764816261499 1.0312783725324686 0.37671909868616926 0.0572106434931688 0.4138400755216236 2.781220991544525 0.024576055653674392 0.0638972897839113 2.0355400324656945e-07 6.691320352037721 0.11600189090631863 SLNYWCNLLGMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLNYWCNLLGMK 12 0 Q9HC38-2;I3L3Q4;F6TLX2;Q9HC38;Q9HC38-3 Q9HC38-2 GLOD4 Glyoxalase domain-containing protein 4 0 40105300.0 27044000.0 6194400.0 6866900.0 False True 26185503.023137175 8667856.22336926 5068252.887415753 1.0 0.3310173654372976 0.19355186275923397 24.642264983416023 -13.999999999999977 0.22243049418226504 5.080481639480734 0.12171209633576334 0.9995004444814635 0.00787330137039821 13.066869366075304 0.14938842094875723 23.450295747942818 0.0748755371192326 1.0000000000000532e-14 13.999999999999977 -4.958769543144971 SLNYWCNLLGMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLNYWCNLLGMK 12 0 Q9HC38-2;I3L3Q4;F6TLX2;Q9HC38;Q9HC38-3 Q9HC38-2 GLOD4 Glyoxalase domain-containing protein 4 0 23079000.0 6686000.0 7896500.0 8496500.0 False True 10143150.812073767 6487307.879363907 6817163.050851756 1.0 0.6395752167701011 0.6720952076091617 23.274002536953287 -9.951361836255304 5.8148232021976005 1.000000274865897 0.6558352126034416 0.9933483273188521 0.013276230666579234 4.731301069532179e-08 8.531874826844456e-09 0.012854665219678742 0.004284885022580189 1.1185056024027946e-10 9.951361836255304 -0.34416506226245536 SLNYWCNLLGMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SLNYWCNLLGMK 12 0 Q9HC38-2;I3L3Q4;F6TLX2;Q9HC38;Q9HC38-3 Q9HC38-2 GLOD4 Glyoxalase domain-containing protein 4 0 91351800.0 13484900.0 24717400.0 53149500.0 False True 18470631.945720196 23625303.53848867 40596682.74831241 1.0 1.2790739162534641 2.1979043742311704 24.138729891081976 -6.949343151681137 0.5660101852911793 0.9883398570289842 2.5330061616189203 0.9991487140867935 0.014931589567404965 0.08375060975781518 0.03706244144859242 0.015892057796306043 0.07648340634039791 1.1237167341137005e-07 6.949343151681137 1.5446663045899363 up SLNYWCNLLGMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLNYWCNLLGMK 12 0 Q9HC38-2;I3L3Q4;F6TLX2;Q9HC38;Q9HC38-3 Q9HC38-2 GLOD4 Glyoxalase domain-containing protein 4 0 47085200.0 27044000.0 3995200.0 16046000.0 False True 22488284.252338525 3973677.064614892 19401144.41167859 1.0 0.1766998771461044 0.8627223043777158 24.4226702588503 -10.716903454842999 9.372184272664638 1.0010672583711615 0.5197110907668507 0.3952341620787878 0.2800674831371752 0.006256172588449894 0.00018897395308639916 0.271632607795594 0.09039139150037552 1.919095314742924e-11 10.716903454842999 -0.48135616760431077 SLNYWCNLLGMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SLNYWCNLLGMK 12 0 Q9HC38-2;I3L3Q4;F6TLX2;Q9HC38;Q9HC38-3 Q9HC38-2 GLOD4 Glyoxalase domain-containing protein 4 0 40646000.0 13447900.0 18641100.0 8557000.0 False True 17408571.64773947 17603706.398156136 6999713.802234483 1.0 1.0112091189538808 0.4020843262659867 24.053294500672198 -6.902711777739694 0.9439959869659678 1.0234754894922944 0.3345125711201347 0.9878669725566153 0.031341973002308385 0.10943568081136612 0.16638898597827714 0.024769203086467562 0.06536554615187957 1.2510890478675613e-07 6.902711777739694 -0.6889629183721597 down SLPEEDVAEIQHAEEFLIK(ub)PESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLPEEDVAEIQHAEEFLIKPESK 23 1 O60832;O60832-2;C9IYT0;H7C0M1;H7C2Q9 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 18987600.0 6741900.0 8554800.0 3690900.0 True False 6527882.074829474 11970776.252692662 2724142.5653734347 1.0 1.8337917437035458 0.41730878930508203 22.63818356480831 -6.747201500761811 1.66043938189553 1.491914739410168 0.4151121793769241 0.6368031338344804 0.3503237218981347 0.30491994159007896 1.6531889177859094 0.1667399555265041 0.40595844828564787 1.789775254594036e-07 6.747201500761811 -1.0768025600332438 SLPEEDVAEIQHAEEFLIK(ub)PESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLPEEDVAEIQHAEEFLIKPESK 23 1 O60832;O60832-2;C9IYT0;H7C0M1;H7C2Q9 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 37159800.0 11724000.0 5355800.0 20080000.0 True False 15176949.114590185 5057745.021873427 16425646.038198935 1.0 0.33325176118639166 1.082275885237589 23.855378472117874 -6.671827998308599 1.930281268529712 0.5751159568361419 1.079319028859775 0.2875159240270567 0.28309600777357835 0.45688283841177874 3.283494013977659 0.11798027203339471 0.3145344378226403 2.1289820592508286e-07 6.671827998308599 0.504203072023633 SLPEEDVAEIQHAEEFLIKPESKVAK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLPEEDVAEIQHAEEFLIKPESKVAK 26 2 O60832;O60832-2;C9IYT0;H7C0M1;H7C2Q9 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 18671000.0 3983600.0 7680300.0 7007100.0 True False 3857142.798512394 10747083.8422354 5171730.30150592 1.0 2.786281038487942 1.3408189874381964 21.879101127500366 -6.593606274103544 2.2151905277356816 2.2062719814931318 1.3452216258130336 0.0025314091723629417 0.7733518519780188 0.6591064634457404 6.102797217815213 0.2908479271450813 0.8612427721508052 2.549140223687908e-07 6.593606274103544 -0.8610503556800981 SLPEEDVAEIQHAEEFLIKPESKVAK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLPEEDVAEIQHAEEFLIKPESKVAK 26 2 O60832;O60832-2;C9IYT0;H7C0M1;H7C2Q9 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 16357600.0 3983600.0 8870200.0 3503800.0 True False 3312539.9034024435 8822414.472003147 4236428.380259214 1.0 2.6633383232429257 1.2789063690697906 21.659506402934642 -6.600971497540862 2.1873408525977958 2.1178784820054983 1.2834427875917558 0.02344939663334933 0.7187558102974796 0.6377188510614914 5.767932102417846 0.2726439657969952 0.7992399342997704 2.506273732719441e-07 6.600971497540862 -0.8344356944137425 SLPHVHVALWINSQGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLPHVHVALWINSQGGR 17 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 16656600.0 3348500.0 6437200.0 6870900.0 False True 5079919.3081407435 5288431.365926834 5512863.603377544 1.0 1.0410463326557062 1.0852266087264404 22.27637415004804 -6.970187343719545 0.2536726575205633 0.9865977459777341 1.140975262371762 0.9999837794907883 0.0001400428443707286 0.07624193976576109 0.008812424099313017 0.0009613653478486736 0.004209318636959814 1.0710571784338327e-07 6.970187343719545 0.15437751639402786 SLPHVHVALWINSQGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLPHVHVALWINSQGGR 17 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 16024900.0 3348500.0 7128400.0 5548000.0 False True 4334699.258802905 6731698.273632792 4538320.927287238 1.0 1.5529793122238096 1.0469748087069288 22.047500472140488 -10.4258374357808 3.566510542368819 0.9973355481773121 1.299977060123709 0.31908128076028097 0.2065754742203742 24350643.879628167 19130919.10014415 469398.67026944534 0.0707162808768639 3.7511338764290676e-11 10.4258374357808 0.302641511946397 SLPLPNDK(ub)TLLYNPFPPTNESDVIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLPLPNDKTLLYNPFPPTNESDVIR 25 1 Q969X6;H3BSH7;Q969X6-2;A0A0J9YWM9;A0A0J9YXV4 Q969X6 CIRH1A Cirhin 1 51951000.0 14278000.0 17889000.0 19784000.0 True False 13824752.705382075 25032170.989902608 14601976.892722093 1.0 1.8106776680466339 1.0562197533585855 23.72075033824043 -10.25641395759668 4.250761371325012 0.9997117274814658 1.4334487107157308 0.30560023984970464 0.30800615400959713 0.0008742661320598063 0.0001529356480522359 0.2984289840404329 0.09940855873449209 5.540973107991526e-11 10.25641395759668 0.433736983234265 SLPLPNDK(ub)TLLYNPFPPTNESDVIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLPLPNDKTLLYNPFPPTNESDVIR 25 1 Q969X6;H3BSH7;Q969X6-2;A0A0J9YWM9;A0A0J9YXV4 Q969X6 CIRH1A Cirhin 1 124376000.0 30648000.0 19238000.0 74490000.0 True False 46495256.668925636 15804828.592819938 59767018.849873126 1.0 0.3399234615556568 1.2854433577052917 25.470580207759763 -6.71902406740087 1.7629301355180798 0.5979925765269886 1.283877080581755 0.5078318725099689 0.2777971232384445 0.35723212990469255 2.1692834075455782 0.12514664407086673 0.31451383299795055 1.9097474227053578e-07 6.71902406740087 0.6858845040547664 SLPLPNDK(ub)TLLYNPFPPTNESDVIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLPLPNDKTLLYNPFPPTNESDVIR 25 1 Q969X6;H3BSH7;Q969X6-2;A0A0J9YWM9;A0A0J9YXV4 Q969X6 CIRH1A Cirhin 1 40230200.0 14278000.0 16676000.0 9276200.0 True False 11872789.622647895 16586163.078073181 11215810.531697173 1.0 1.3969895538647723 0.9446651451064623 23.501155613674705 -6.674908408004321 1.9199476596919993 1.2523276775667727 0.9464516524834549 0.30086433776215604 0.1684459385218965 0.45001544782140235 3.2025906581318404 0.07051444976648416 0.187201148134393 2.113934818222556e-07 6.674908408004321 -0.3058760250833178 SLPLPNDK(ub)TLLYNPFPPTNESDVIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLPLPNDKTLLYNPFPPTNESDVIR 25 1 Q969X6;H3BSH7;Q969X6-2;A0A0J9YWM9;A0A0J9YXV4 Q969X6 CIRH1A Cirhin 1 162153000.0 30648000.0 19805000.0 111700000.0 True False 39674440.1623985 18702834.340005822 91371746.13878584 1.0 0.47140764339584695 2.3030380709790963 25.241706529852213 -6.829533594359209 1.3301387513650544 0.7174698157717301 2.351808211676327 0.9049107353706716 0.2373543639211368 0.1813885384506145 0.6278341252437779 0.14011883240456685 0.3224346571084944 1.4806977131379473e-07 6.829533594359209 1.6343383959045967 up SLPYNQPGTCYTLVALPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLPYNQPGTCYTLVALPK 18 0 Q9Y678;H0Y8X7;H0Y8G2 Q9Y678 COPG1 Coatomer subunit gamma-1 0 16362700.0 3361900.0 6971000.0 6029800.0 False True 4407483.456685911 5930953.972745172 5405894.137925828 1.0 1.345655413351181 1.2265262458842319 22.07152372378126 -10.230795510382151 4.590871626804535 0.999915825010197 1.2860908296196636 0.8849214617086281 0.048634278969468155 4.191329299056477e-05 7.022491376353682e-06 0.04710375483575246 0.015696646041018014 5.8776603981413e-11 10.230795510382151 0.28617500460946654 SLPYNQPGTCYTLVALPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLPYNQPGTCYTLVALPK 18 0 Q9Y678;H0Y8X7;H0Y8G2 Q9Y678 COPG1 Coatomer subunit gamma-1 0 14687900.0 3361900.0 5244800.0 6081200.0 False True 4604885.281931394 5013067.393765732 4644945.806245354 1.0 1.0886411032726395 1.0086995705346122 22.134733785304153 -10.854568532061894 4.190834233619659 0.9880385128507299 1.0486703369036339 0.3307556133945899 0.0326359940773875 0.004493684081054838 0.00015594099524801164 0.03893148621644346 0.010533221795716747 1.3977563307063027e-11 10.854568532061894 0.060631824052904015 SLPYVLPWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLPYVLPWK 9 0 Q8WW33;G3V1V4 Q8WW33 GTSF1 Gametocyte-specific factor 1 0 7922400.0 2142100.0 2113100.0 3667200.0 False True 2808313.8441259093 1797833.7167992885 3287753.3222663463 1.0 0.6401826208134748 1.1707214737210623 21.42127274288073 -6.724033000168106 1.744497119219338 0.7820415914967217 1.1701053594089519 0.531587023245439 0.15134284819795163 0.3475535169131589 2.0691004287672548 0.0688230801854803 0.17197753865644078 1.8878478942115297e-07 6.724033000168106 0.3880637679122302 SLPYVLPWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLPYVLPWK 9 0 Q8WW33;G3V1V4 Q8WW33 GTSF1 Gametocyte-specific factor 1 0 5985000.0 1709700.0 2924000.0 1351300.0 False True 2593739.895812522 2402189.354683725 1084214.9627041703 1.0 0.9261489012687637 0.41801221643488123 21.30660238051127 -6.933011043074612 0.7216476419834045 1.006930345206775 0.30521719621617727 0.9970976532476403 0.013937465922723083 0.09110423998295993 0.07023985203803892 0.012933264853695057 0.04524047918005823 1.1667799482478004e-07 6.933011043074612 -0.7017131489905978 down SLQAK(ub)DEDKDEDEKEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLQAKDEDKDEDEKEK 16 3 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 59871500.0 27243100.0 19697100.0 12931300.0 True False 35715967.92255565 16758369.458694438 11593293.121788496 1.0 0.46921224408735823 0.3245969183007078 25.090065883907144 -13.999999999999998 0.18246950995853176 3.775268486525418 0.2126033976201299 0.9994953673110144 0.006522817634586867 12.237692552230714 0.13543383271963658 12.048363080314733 0.10575093849654385 1.0000000000000041e-14 13.999999999999998 -3.562665088905288 SLQAK(ub)DEDKDEDEKEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLQAKDEDKDEDEKEK 16 3 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 57988800.0 21643100.0 20468100.0 15877600.0 True False 20956051.637334 28641119.069731437 11718780.242210085 1.0 1.3667230624067654 0.5592074521009784 24.320863586247825 -6.783202039462113 1.5231015340923109 1.206779684592469 0.5521212388448408 0.7786716214370635 0.15531091901917848 0.24561877121253126 1.1255768482045665 0.08029326432868705 0.18898110543754737 1.6473958231890465e-07 6.783202039462113 -0.6546584457476282 SLQAK(ub)DEDKDEDEKEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLQAKDEDKDEDEKEK 16 3 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 67224300.0 27243100.0 24688700.0 15292500.0 True False 37315610.28709511 23597871.599386856 11680726.458923757 1.0 0.6323860555363269 0.31302520229619063 25.153275945430035 -7.578081697364727 0.257434961203317 1.1309715886877016 4.888550816942519e-14 0.9998107144266155 0.003861715437923029 0.12879952919646104 0.02887744144571074 0.030961865455086966 0.07100944096243292 2.641911726994994e-08 7.578081697364727 -1.1309715886876528 down SLQAK(ub)DEDKDEDEKEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLQAKDEDKDEDEKEK 16 3 Q05086-2;Q05086-3;Q05086;A0A1B0GVL3;A0A0D9SG77 Q05086-2 UBE3A Ubiquitin-protein ligase E3A 1 55784600.0 21643100.0 25095900.0 9045600.0 True False 17997196.601900175 24960703.405553862 10936993.137871105 1.0 1.3869217499640176 0.6077053765538327 24.1012688616821 -6.771694587574095 1.5680063594602027 1.2214470643651805 0.6030430499232794 0.7369900263284175 0.16314433367856088 0.26369625505338967 1.2797492563687796 0.08200056575018577 0.19489039113014642 1.6916301322072422e-07 6.771694587574095 -0.6184040144419011 SLQAPSVK(ub)DFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLQAPSVKDFLK 12 1 O14777;V9GYM9 O14777 NDC80 Kinetochore protein NDC80 homolog 1 4630600.0 2472600.0 2158000.0 0.0 True False 2394108.666432811 3019700.653821331 0.0 1.0 1.2613047587019697 0.0 21.191057205718284 -6.894619251272639 1.3094252185547544 1.1360788976263445 4.0593868991994155e-19 0.9428236538177607 0.1299750475338379 0.1381778262494562 0.4757717631911427 0.08091684913105518 0.16222148131372965 1.274620058805849e-07 6.894619251272639 -1.1360788976263445 down SLQAPSVK(ub)DFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLQAPSVKDFLK 12 1 O14777;V9GYM9 O14777 NDC80 Kinetochore protein NDC80 homolog 1 8095300.0 2472600.0 4464800.0 1157900.0 True False 2056076.4547527067 4440747.236206593 1400011.5364752985 1.0 2.1598162003857495 0.6809141426813742 20.97146248115256 -6.697530663897335 1.8393402564901489 1.7219524393759522 0.6854749907311727 0.405869738823432 0.4898018831579745 0.4007631721298782 2.634129017152004 0.21256534005329697 0.548402620112543 2.0066394037672002e-07 6.697530663897335 -1.0364774486447796 SLQELFLAHILSPWGAEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLQELFLAHILSPWGAEVK 19 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 1355820000.0 529950000.0 361430000.0 464440000.0 False True 803972894.534623 296929992.6345212 372643230.4287166 1.0 0.3693283625020693 0.4635022311845723 29.582571621722416 -10.782842808919053 7.164690033044883 1.0162270635562758 0.4164152968433208 0.9808435929492019 0.038446320896000176 0.009557339255042865 0.00028967646619021116 0.03570125069992428 0.012408496712762904 1.6487590450179475e-11 10.782842808919053 -0.599811766712955 SLQELFLAHILSPWGAEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLQELFLAHILSPWGAEVK 19 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 1130910000.0 440450000.0 224400000.0 466060000.0 False True 366253690.2433996 223191112.6600876 563510991.1820341 1.0 0.609389389392261 1.5385810605963972 28.448268054794962 -6.79250464665082 1.486299027016783 0.7823988770049386 1.5491591376220173 0.8093501364551903 0.1663319939795139 0.23163232292460173 1.0107941370132947 0.08807414597512486 0.20583441790451076 1.6124837747834265e-07 6.79250464665082 0.7667602606170787 SLQELFLAHILSPWGAEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLQELFLAHILSPWGAEVK 19 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 1297530000.0 529950000.0 402040000.0 365540000.0 False True 686030721.8762423 379666120.57843655 299015470.7571335 1.0 0.5534243707629861 0.43586309070729184 29.353697943814865 -13.999999999999998 0.18735471009582505 3.372446719930531 0.3492413529545601 0.9994910826270366 0.005482190779814473 12.30881986744083 0.13725841287232693 10.651588290990608 0.08258213300518298 1.0000000000000041e-14 13.999999999999998 -3.023205366975971 SLQEQGSK(ub)SEGESSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLQEQGSKSEGESSSK 16 1 Q9UJC3;Q9UJC3-2 Q9UJC3 HOOK1 Protein Hook homolog 1 1 2731230.0 692400.0 1137000.0 901830.0 True False 670420.1410005973 1591010.029376671 665613.6686799217 1.0 2.37315368688372 0.9928306564395545 19.354705966083266 -6.64739344241983 2.0182748730813374 1.8928769183570076 0.9986636202918272 0.18347355621482386 0.5864550083125861 0.5148754749162461 4.017180891560571 0.23592627658505538 0.6493349709904556 2.25219794350644e-07 6.64739344241983 -0.8942132980651804 SLQEQGSK(ub)SEGESSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLQEQGSKSEGESSSK 16 1 Q9UJC3;Q9UJC3-2 Q9UJC3 HOOK1 Protein Hook homolog 1 1 3081550.0 918120.0 1174100.0 989330.0 True False 1257573.7752600766 1122224.379770507 755670.6298909286 1.0 0.8923726001986817 0.6008956649359595 20.26221160719179 -6.953725730278109 0.5163251987825705 1.0050973942013528 0.47524464305850445 0.9994621539695845 0.003910031145594608 0.08202329849015358 0.030031205579640386 0.004455933903526888 0.0240679538960364 1.1124340402646591e-07 6.953725730278109 -0.5298527511428484 SLQEQGSK(ub)SEGESSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLQEQGSKSEGESSSK 16 1 Q9UJC3;Q9UJC3-2 Q9UJC3 HOOK1 Protein Hook homolog 1 1 2432750.0 692400.0 1466400.0 273950.0 True False 575761.2785208982 1458500.2121423907 331231.67839831416 1.0 2.53316828788696 0.5752934258608563 19.135111241517542 -6.697821894034538 1.8386933950461168 1.9540601378680622 0.581359040533287 0.40723683688569057 0.6474304523919291 0.4000621928276995 2.6279744837394277 0.2810773874319361 0.7247916122638118 2.00529423822871e-07 6.697821894034538 -1.372701097334775 SLQK(ub)IGPILDNSTLQSEVK(ub)PILEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLQKIGPILDNSTLQSEVKPILEK 24 2 P30153;B3KQV6;E9PH38 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 2 35876200.0 14893000.0 7711200.0 13272000.0 True False 14420229.867016025 10790322.37337676 9795665.04853455 1.0 0.7482767246351532 0.6793002010973882 23.781590826388115 -13.999999999719593 0.18165528286618265 2.3127881539852067 0.6254348165651312 0.999496233921756 0.0030935228728317297 12.226581307611681 0.13512520322658725 5.667497659450418 0.05078483098958019 1.0000000006456606e-14 13.999999999719593 -1.6873533374200753 SLQK(ub)IGPILDNSTLQSEVK(ub)PILEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLQKIGPILDNSTLQSEVKPILEK 24 2 P30153;B3KQV6;E9PH38 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 2 36553100.0 14893000.0 15264000.0 6396100.0 True False 12384189.371767385 15181769.802333213 7733494.937774981 1.0 1.2258993581722482 0.6244651713260512 23.56199610182239 -6.804937826347765 1.4354704019115136 1.1238680172131879 0.6150946680006257 0.8462723185474803 0.09725757126472247 0.21377485726857876 0.8690340964649393 0.053286793745453906 0.12358302968293436 1.5669753824428045e-07 6.804937826347765 -0.5087733492125621 SLQK(ub)IGPILDNSTLQSEVKPILEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLQKIGPILDNSTLQSEVKPILEK 24 2 P30153;B3KQV6;E9PH38 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 65942300.0 36428800.0 11536500.0 17977000.0 True False 47758509.57700104 9815299.1689248 16116912.487560557 1.0 0.2055193777163333 0.3374668227779441 25.50925447863208 -9.547828996682714 10.240240032308584 1.00000002768672 0.2714931002470177 0.9759873501029094 0.0538673188774795 0.0 0.0 0.05215680722932955 0.01738560240977651 2.832507075034472e-10 9.547828996682714 -0.7285069274397022 SLQK(ub)IGPILDNSTLQSEVKPILEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLQKIGPILDNSTLQSEVKPILEK 24 2 P30153;B3KQV6;E9PH38 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 367845000.0 80585000.0 100168000.0 187092000.0 True False 78026873.28499882 140165604.7692194 138086992.56030932 1.0 1.79637602877222 1.7697363324548012 26.21746775328695 -10.186673528792054 4.47206695441912 0.9998201575132576 1.783056180602006 0.9991327241166506 0.010875610540437189 7635330.140080019 4.798611051439878 14193.659405069204 0.00372301075321342 6.506185946022014e-11 10.186673528792054 0.7832360230887484 SLQK(ub)IGPILDNSTLQSEVKPILEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLQKIGPILDNSTLQSEVKPILEK 24 2 P30153;B3KQV6;E9PH38 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 656782000.0 208366000.0 191663000.0 256753000.0 True False 316106455.5950586 157459240.18014595 206005657.01116216 1.0 0.49812092538171926 0.6516970892712842 28.235835257675305 -10.865762766797385 11.011115598242297 1.0141377471559434 0.5749090073265103 0.9108367972774944 0.06269720636391295 0.019924717166707726 0.00024290300848648462 0.05558583202519713 0.02023543634176372 1.3621885742848718e-11 10.865762766797385 -0.4392287398294331 SLQK(ub)IGPILDNSTLQSEVKPILEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLQKIGPILDNSTLQSEVKPILEK 24 2 P30153;B3KQV6;E9PH38 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 121494900.0 36428800.0 24038000.0 61028100.0 True False 49897511.81130386 22975921.676964004 46614519.69317275 1.0 0.46046227242455406 0.9342052940325699 25.57246454015497 -10.304218690854752 8.294321343011614 1.0000005127789466 0.697333783228563 0.352427284393905 0.1934047786906574 1.8339027880389884e-06 1.537481052490135e-07 0.18726368982913702 0.06242112391215392 4.9634232319959724e-11 10.304218690854752 -0.30266672955038365 SLQK(ub)IGPILDNSTLQSEVKPILEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLQKIGPILDNSTLQSEVKPILEK 24 2 P30153;B3KQV6;E9PH38 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 308183000.0 80585000.0 110231000.0 117367000.0 True False 67009998.02080679 109637163.72385965 141907897.05630547 1.0 1.6361314275791652 2.1177123003681135 25.997873028721227 -6.974205583730524 0.1210915826201783 0.14775164065256058 3.618475276370981 0.9999994256917044 0.00034685370061768225 0.07496022794245667 0.003609069510666556 0.033497572039172994 0.0689886528139556 1.0611930970258945e-07 6.974205583730524 3.47072363571842 SLQK(ub)IGPILDNSTLQSEVKPILEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLQKIGPILDNSTLQSEVKPILEK 24 2 P30153;B3KQV6;E9PH38 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 553027000.0 208366000.0 205624000.0 139037000.0 True False 269733894.50790673 194180843.64197695 113733692.64009304 1.0 0.7198978237282112 0.42165146819084376 28.006961579767754 -6.970328518589054 0.25021490729670914 1.0943995434771876 0.0384121208719993 0.9999848323527357 0.0009196779920707337 0.07619624276811152 0.008647879712964629 0.006642325184502784 0.028574049148229357 1.0707090695117673e-07 6.970328518589054 -1.0559874226051882 down SLQK(ub)IGPILDTNALQGEVKPVLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLQKIGPILDTNALQGEVKPVLQK 24 2 P30154;P30154-2;P30154-4;P30154-3;P30154-5;H0YDG7 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 13272100.0 4316600.0 3877800.0 5077700.0 True False 5659104.4020138625 3299247.355546007 4552308.312737738 1.0 0.5829981426693469 0.8044220409006313 22.432142322556533 -10.14453169541703 5.016142459876391 1.000015666850734 0.6937100917843589 0.7184099927073735 0.09039592792295302 1.5838829531634128e-05 2.7013571333637205e-06 0.08752995419560411 0.029175160283900558 7.169160521377074e-11 10.14453169541703 -0.3063055750663751 SLQK(ub)IGPILDTNALQGEVKPVLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLQKIGPILDTNALQGEVKPVLQK 24 2 P30154;P30154-2;P30154-4;P30154-3;P30154-5;H0YDG7 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 49831600.0 8221800.0 6928200.0 34681600.0 True False 7960803.45938578 9694666.390085716 25597448.534301985 1.0 1.2177999921170912 3.2154353093747865 22.924482614210547 -6.927645533004265 0.7658714298166692 0.9668220564917426 3.6019882985267655 0.9960549553422906 0.06262135852589958 0.09387884066744873 0.08380532191217122 0.056271627628304455 0.18314725182425604 1.1812843952996702e-07 6.927645533004265 2.635166242035023 up SLQK(ub)IGPILDTNALQGEVKPVLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLQKIGPILDTNALQGEVKPVLQK 24 2 P30154;P30154-2;P30154-4;P30154-3;P30154-5;H0YDG7 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 141448000.0 10394000.0 29672000.0 101382000.0 True False 15768457.903184963 24376799.771605834 81343803.2626908 1.0 1.5459216063659675 5.15864035418839 23.910538241003785 -6.9337983240555365 0.7149246565139696 0.9520429209319532 5.977553895984557 0.9972335562369634 0.09705385639011449 0.09071293214456651 0.06836566695554334 0.09051099347088486 0.32033600909479554 1.1646667471651555e-07 6.9337983240555365 5.025510975052604 up SLQK(ub)IGPILDTNALQGEVKPVLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLQKIGPILDTNALQGEVKPVLQK 24 2 P30154;P30154-2;P30154-4;P30154-3;P30154-5;H0YDG7 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 53713700.0 4316600.0 6872100.0 42525000.0 True False 5912563.671728801 6568467.89900426 32481470.829866435 1.0 1.1109339812121932 5.493635693967763 22.495352384079425 -6.912338340022053 0.8796666213828254 0.8741319855503601 6.089283291927519 0.9917743461153123 0.18979487980545398 0.10289178432023649 0.13053238840320416 0.15720701711791313 0.4413219948499474 1.2236625253521848e-07 6.912338340022053 5.215151306377159 up SLQK(ub)IGPILDTNALQGEVKPVLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLQKIGPILDTNALQGEVKPVLQK 24 2 P30154;P30154-2;P30154-4;P30154-3;P30154-5;H0YDG7 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 73999800.0 8221800.0 25815800.0 39962200.0 True False 6836790.98749729 25676725.16136489 48318111.2556638 1.0 3.7556691740790282 7.067367035795747 22.704887889644823 -6.968678767316207 0.2879989413323029 0.3372324503304678 10.58783713385831 0.9999701652301092 0.013548555439208817 0.07673377616897886 0.010556955600919514 0.05848724742264898 0.301021848335972 1.0747840992176319e-07 6.968678767316207 10.250604683527841 SLQK(ub)IGPILDTNALQGEVKPVLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLQKIGPILDTNALQGEVKPVLQK 24 2 P30154;P30154-2;P30154-4;P30154-3;P30154-5;H0YDG7 P30154 PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 1 131225000.0 10394000.0 18840000.0 101991000.0 True False 13455237.89637072 17791537.438308995 83429684.5160332 1.0 1.3222759475035297 6.200535817990753 23.681664563096234 -6.920315038839506 0.8223926989127922 0.8935823739193389 6.992912928450621 0.9942678791667511 0.1801337535727168 0.09798667990344387 0.10465817640392344 0.1554631071219052 0.4670934868028894 1.2013926237510683e-07 6.920315038839506 6.0993305545312815 up SLQPAVAEK(ub)QGHQWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLQPAVAEKQGHQWK 15 1 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A0A0MSW3;A0A494BZU9 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 1 31624300.0 4059600.0 6879000.0 20685700.0 True False 6158709.996514315 5651388.704127682 16597162.328135619 1.0 0.9176253967675432 2.69490889123359 22.554196764963667 -6.896033871541266 0.986016698970736 0.9178531244334772 2.867130728668815 0.9844871783626311 0.10201857899827892 0.1143833164445478 0.19434798841628412 0.07814285009474185 0.19955270205291445 1.2704750143224565e-07 6.896033871541266 1.9492776042353377 up SLQPAVAEK(ub)QGHQWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLQPAVAEKQGHQWK 15 1 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A0A0MSW3;A0A494BZU9 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 1 3723800.0 1144900.0 1394200.0 1184700.0 True False 952035.077669812 1386689.1678729672 1432415.2925660976 1.0 1.4565526002119675 1.5045824740744402 19.8606552049532 -11.800018366041437 0.3651362202539108 1.354395726303005e-08 1.510579209876518 0.9996196664919014 0.004434562904867683 4.774949386923015 0.18858510788676697 3.6942612342073944 0.013619873191352567 1.5848261697385526e-12 11.800018366041437 1.5105791963325608 SLQPAVAEK(ub)QGHQWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLQPAVAEKQGHQWK 15 1 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A0A0MSW3;A0A494BZU9 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 1 31323800.0 4059600.0 3967200.0 23297000.0 True False 5255232.226679495 3746421.832550923 19057185.04740639 1.0 0.7128936783290527 3.626325959613706 22.325323087056116 -6.882673702067871 1.0647397563345247 0.8148787245028392 3.8437149225573255 0.9757803575202673 0.2040239611904996 0.1252896331790753 0.2581790246455127 0.14723120923350827 0.35860001873090364 1.3101659186287076e-07 6.882673702067871 3.0288361980544862 up SLQSLLGPSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLQSLLGPSSK 11 0 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2;I3L167;E7EP81 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 0 5484140.0 794140.0 1909500.0 2780500.0 False True 1041125.2304626985 1624610.0431727038 2492800.5324393427 1.0 1.5604367233043541 2.3943330345874805 19.98971218119039 -6.965391021309071 0.3512765864429337 0.9205884340229789 3.0623752204143213 0.9999209805871748 0.005092416591619147 0.0778285121431906 0.014393471924934032 0.011409904378664541 0.07161540939627842 1.0829514289709174e-07 6.965391021309071 2.1417867863913425 SLQSLLGPSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLQSLLGPSSK 11 0 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2;I3L167;E7EP81 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 0 8186140.0 794140.0 4240200.0 3151800.0 False True 1087755.0188265545 4052853.943533689 2407409.753358567 1.0 3.7258885258059444 2.2131911245563605 20.052922242713283 -9.645939289618097 6.53620152683323 0.9999999989758493 2.969539825185057 0.6932788114771737 0.6175561280633021 2.5864000667258528e-08 5.452764584000072e-09 0.597946154283209 0.19931538327605466 2.2597516406782287e-10 9.645939289618097 1.9695398262092074 SLQSLLGPSSK(ub)FR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLQSLLGPSSKFR 13 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2;I3L167;E7EP81 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 6937100.0 2429000.0 1694900.0 2813200.0 True False 2351892.7245673803 2371682.4087867364 2076338.5258090275 1.0 1.0084143651675255 0.8828372587406003 21.165390826239857 -6.890867031702526 1.0172049631466327 1.0066077992405555 0.8718497753316391 0.9814486536241993 0.007806813225132054 0.11844385008575495 0.21774429682145918 0.005840858490514948 0.0146080361777905 1.285680237461618e-07 6.890867031702526 -0.13475802390891645 SLQSLLGPSSK(ub)FR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLQSLLGPSSKFR 13 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2;I3L167;E7EP81 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 5806500.0 2429000.0 3377500.0 0.0 True False 2019821.1229452116 3359304.7371187364 0.0 1.0 1.6631694257263487 0.0 20.945796101674134 -6.812242000397575 1.4962533174808743 1.3657604370554537 9.582887636876098e-21 0.8272217699877618 0.2841542008258916 0.21478205025812058 0.961671245696892 0.15136363483079435 0.33580049367381354 1.5408416158954596e-07 6.812242000397575 -1.3657604370554537 SLQSVAEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLQSVAEER 9 0 P61313;A0A2R8YEM3;E7EQV9;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 18640700.0 1548200.0 9603400.0 7489100.0 False True 2029705.192790128 8170610.15376001 6714199.772519862 1.0 4.025515716658489 3.307967973068152 20.95283876580553 -9.991179472701338 7.379944082340884 0.9999999042983668 3.666741844863321 0.9484965103602611 0.29293763964695974 4.610953245012902e-07 6.299710533966643e-08 0.2836356668627349 0.0945452166524984 1.0205176664391488e-10 9.991179472701338 2.6667419405649544 SLQSVAEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLQSVAEER 9 0 P61313;A0A2R8YEM3;E7EQV9;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 16060700.0 4214300.0 2189200.0 9657200.0 False True 4080519.353291189 3063358.9765271796 7127689.610210055 1.0 0.7507277165727428 1.7467603981491073 21.96032135405369 -6.840426806006583 1.2804306545725042 0.8674012982964578 1.7797947353846515 0.9251841281262566 0.11575518913283293 0.16829951335003634 0.535810567733392 0.0708834928439122 0.16331914685231871 1.4440199522613607e-07 6.840426806006583 0.9123934370881936 SLQSVAEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLQSVAEER 9 0 P61313;A0A2R8YEM3;E7EQV9;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 16869600.0 1548200.0 8023900.0 7297500.0 False True 2120611.378531839 7669377.566510993 5573980.796730174 1.0 3.6165879539044665 2.6284782082934988 21.016048827328422 -10.369023441961202 6.029384139094453 0.9996670002932189 3.1225330810989442 0.8601847808405055 0.4033941144363647 0.0018059983535387526 0.0001889972637968645 0.39063751569398225 0.13019489059751008 4.275398081653183e-11 10.369023441961202 2.1228660808057254 SLQSVAEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLQSVAEER 9 0 P61313;A0A2R8YEM3;E7EQV9;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 5078300.0 0.0 5078300.0 0.0 False True 0.0 4795688.14081553 0.0 0.0 SLQTGFAIGVQQLHPTLIQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLQTGFAIGVQQLHPTLIQR 20 0 F6VZ39;Q9H0Z9;A6NG75 F6VZ39 RBM38 RNA-binding protein 38 0 10193000.0 4969500.0 2257500.0 2966000.0 False True 4811745.94266677 3158931.522706975 2189115.621907286 1.0 0.6565042212008869 0.45495245343191004 22.19812904040616 -9.677681992758222 0.11774855535800438 1.6983338822231524 9.204827251213207e-12 0.999897859355247 0.0022741078407290177 1.1656012136321858 0.049421658178278684 0.4837832309930233 0.22868766286166606 2.10047737154286e-10 9.677681992758222 -1.6983338822139475 SLQTGFAIGVQQLHPTLIQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLQTGFAIGVQQLHPTLIQR 20 0 F6VZ39;Q9H0Z9;A6NG75 F6VZ39 RBM38 RNA-binding protein 38 0 64197000.0 16645000.0 26654000.0 20898000.0 False True 25251681.912498925 21897385.451347474 16767501.140081227 1.0 0.8671654239596943 0.6640152207755219 24.58987614736351 -6.964933225545869 0.35919686101805653 1.0176668465215146 0.5065607609737235 0.9999117602521287 0.0012978340690183547 0.07798363029234073 0.014939913673333641 0.0027300488179649598 0.01735996081516592 1.084093584783899e-07 6.964933225545869 -0.5111060855477911 SLQTGFAIGVQQLHPTLIQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLQTGFAIGVQQLHPTLIQR 20 0 F6VZ39;Q9H0Z9;A6NG75 F6VZ39 RBM38 RNA-binding protein 38 0 56265000.0 16645000.0 27638000.0 11982000.0 False True 21547280.622002184 26099921.004245423 9801398.945702184 1.0 1.2112860765174462 0.4548786975788425 24.361002469455958 -6.832151351366348 1.3181831264806094 1.1127449318830362 0.43360418419592217 0.9101131130940034 0.09554069789522987 0.17818115460263081 0.6047363612609418 0.05689267455911397 0.13093015253939475 1.4717994918062112e-07 6.832151351366348 -0.6791407476871141 down SLQTICSWFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLQTICSWFK 10 0 D6RGX2;Q9NUQ7;H0YA18;H0Y9B0 D6RGX2 UFSP2 Ufm1-specific protease 2 0 3470270.0 741370.0 1120500.0 1608400.0 False True 971943.2494372933 953325.7676747901 1441978.196862235 1.0 0.9808450938125434 1.4836032841393452 19.89051255355018 -6.898042507123698 0.9735605647883241 0.9779589440926295 1.5343273138668505 0.9855665979262525 0.02794664845980171 0.11286143626409331 0.18565919276284024 0.02160606186224699 0.05568298088399215 1.2646125658534607e-07 6.898042507123698 0.556368369774221 SLQTICSWFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLQTICSWFK 10 0 D6RGX2;Q9NUQ7;H0YA18;H0Y9B0 D6RGX2 UFSP2 Ufm1-specific protease 2 0 3007610.0 741370.0 697440.0 1568800.0 False True 1015474.5237709272 666624.7946743402 1198281.7504501932 1.0 0.6564662914425993 1.1800214800076108 19.953722615073072 -6.729666170880506 1.7241889266416446 0.7931914518266069 1.1797067652258852 0.5578517445703068 0.14441706720613792 0.33685432501646073 1.9616533533252043 0.0663766745144988 0.16478775755558783 1.8635190173481645e-07 6.729666170880506 0.38651531339927836 SLSALIGQCIHIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLSALIGQCIHIER 14 0 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7;B4DSP0;A0A087WZG9;Q86TG7-2 A0A087WUL4;B4DSP0 PEG10 Retrotransposon-derived protein PEG10 0 5105000.0 1791900.0 2013200.0 1299900.0 False True 2349198.252784284 1712838.4073921384 1165398.8175212757 1.0 0.7291161592522352 0.49608363880742634 21.163737039268412 -6.972879541683979 0.17632425015628492 1.1891651170115018 0.029755905664956693 0.9999970075335863 0.00035616269832163927 0.0753789222490853 0.005537932772423507 0.009272529484024742 0.02645044456119523 1.064438215745811e-07 6.972879541683979 -1.159409211346545 down SLSALIGQCIHIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLSALIGQCIHIER 14 0 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7;B4DSP0;A0A087WZG9;Q86TG7-2 A0A087WUL4;B4DSP0 PEG10 Retrotransposon-derived protein PEG10 0 24394100.0 6008100.0 12274000.0 6112000.0 False True 9114726.950945329 10083608.802800296 4903960.5210152315 1.0 1.1062985053824876 0.5380260481096057 23.119768007550466 -6.858347131995156 1.193982025921743 1.0574438122142908 0.5113542961448931 0.9516019680201936 0.05426818364653111 0.14852177371757716 0.4032621853653731 0.03547136993997727 0.08265695143710562 1.385647836478943e-07 6.858347131995156 -0.5460895160693977 SLSALIGQCIHIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLSALIGQCIHIER 14 0 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7;B4DSP0;A0A087WZG9;Q86TG7-2 A0A087WUL4;B4DSP0 PEG10 Retrotransposon-derived protein PEG10 0 8805400.0 1791900.0 1881200.0 5132300.0 False True 2454413.8542767083 1798082.3637034965 3920156.443036411 1.0 0.7325913519313041 1.5971864061171714 21.226947100791303 -6.823638577943565 1.355999817495824 0.8563725682181695 1.6175844801645953 0.8925575864987683 0.1184699371143142 0.18879689408292558 0.6811005144786983 0.06863616710203234 0.15806751482590675 1.500933400238904e-07 6.823638577943565 0.7612119119464258 SLSALIGQCIHIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLSALIGQCIHIER 14 0 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7;B4DSP0;A0A087WZG9;Q86TG7-2 A0A087WUL4;B4DSP0 PEG10 Retrotransposon-derived protein PEG10 0 6991300.0 2910800.0 1342500.0 2738000.0 False True 2420459.170304204 1335267.686034615 3310503.1409183573 1.0 0.5516588349915434 1.3677169941694545 21.206849327519446 -6.757537575505193 1.6216641104837959 0.7387828301587974 1.3703482767966735 0.6808592901015209 0.18851328327735828 0.28707675651524744 1.4873454800599712 0.09174362639548371 0.2210204012627615 1.747682045031194e-07 6.757537575505193 0.6315654466378761 SLSALIGQCIHIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLSALIGQCIHIER 14 0 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7;B4DSP0;A0A087WZG9;Q86TG7-2 A0A087WUL4;B4DSP0 PEG10 Retrotransposon-derived protein PEG10 0 16859400.0 6008100.0 6131000.0 4720300.0 False True 7777603.887356654 5789804.460417861 3861253.834368049 1.0 0.744420073877743 0.4964580210423084 22.890894329642915 -6.971495598203372 0.21955135685192215 1.1149989033108443 0.1188811306513626 0.9999918139904 0.0005881550424933605 0.07582037360696961 0.00726867243706238 0.006892004634897249 0.02515614206414681 1.0678356155441953e-07 6.971495598203372 -0.9961177726594816 down SLSCLK(ub)ALHGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLSCLKALHGR 11 1 A0A3B3ISJ0;O43299-2;O43299;O43299-3;A0A3B3IRY4 A0A3B3ISJ0 AP5Z1 AP-5 complex subunit zeta-1 1 24296000.0 1686000.0 5645000.0 16965000.0 True False 2557785.2631104337 4637605.645413689 13611860.313976353 1.0 1.8131333041515996 5.321736937925525 21.286463718277965 -6.943137319644757 0.6296994333044142 0.9617269815653547 6.362140800105581 0.9985466392203889 0.07148990836172016 0.08636405969686628 0.04830746037162882 0.07137172568441798 0.29805718349646215 1.1398893087833521e-07 6.943137319644757 5.400413818540226 SLSCLK(ub)ALHGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLSCLKALHGR 11 1 A0A3B3ISJ0;O43299-2;O43299;O43299-3;A0A3B3IRY4 A0A3B3ISJ0 AP5Z1 AP-5 complex subunit zeta-1 1 6708690.0 546590.0 1968100.0 4194000.0 True False 454513.80304266064 1957497.454662735 5070946.009134987 1.0 4.3067942965837815 11.156858109013312 18.79396458245095 -6.9593520526718615 0.44447374569902764 0.7661871832954449 14.966531782405214 0.9997454012949988 0.06749114399913748 0.07993342823786832 0.021992923420840613 0.0908406925623827 0.567113171082164 1.0981153119659891e-07 6.9593520526718615 14.20034459910977 SLSCLK(ub)ALHGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLSCLKALHGR 11 1 A0A3B3ISJ0;O43299-2;O43299;O43299-3;A0A3B3IRY4 A0A3B3ISJ0 AP5Z1 AP-5 complex subunit zeta-1 1 16473300.0 1686000.0 5229900.0 9557400.0 True False 2182560.236028577 4938851.467548416 7818051.267205316 1.0 2.2628706351469283 3.5820552111914084 21.057590040370414 -6.97057563853788 0.24404576012185356 0.549459556020959 5.333814284136108 0.9999865308046051 0.003868963826840858 0.07611634247070262 0.008359032590007464 0.030650725578236695 0.1276996167673915 1.0700999936037217e-07 6.97057563853788 4.784354728115149 SLSDIK(ub)GAADEIMLPCEFCEELYPEELLIDHQTSCNPSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLSDIKGAADEIMLPCEFCEELYPEELLIDHQTSCNPSR 39 1 O14545 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 200605000.0 34662000.0 113660000.0 52283000.0 True False 52584788.131633416 93376484.97036675 41949242.13354702 1.0 1.7757318853623807 0.7977448160205028 25.648142177397165 -6.695342271161156 1.8473738867648348 1.4838875762452075 0.8008915253400131 0.3954873057229481 0.3277349642232451 0.4053305743263635 2.6859293820362837 0.1417057253074087 0.3665540401562037 2.0167762987019818e-07 6.695342271161156 -0.6829960509051944 SLSDIK(ub)GAADEIMLPCEFCEELYPEELLIDHQTSCNPSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLSDIKGAADEIMLPCEFCEELYPEELLIDHQTSCNPSR 39 1 O14545 O14545 TRAFD1 TRAF-type zinc finger domain-containing protein 1 1 105921000.0 34662000.0 30162000.0 41097000.0 True False 44870642.29016763 28483458.185471106 33617767.69082976 1.0 0.6347905162862489 0.7492152101017802 25.419268499489615 -10.666037917513437 9.778305147828807 1.0001670950285615 0.6920028631940148 0.9061943925757211 0.04671368563704158 0.00017025610981478813 5.814796863125542e-06 0.04525422927764037 0.015076777209352556 2.1575560283775945e-11 10.666037917513437 -0.30816423183454666 SLSDSESDDSK(ub)SK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLSDSESDDSKSK 13 1 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 42791900.0 13443700.0 17828200.0 11520000.0 True False 17624820.88897598 15168302.053779298 10328020.90764297 1.0 0.8606216284028626 0.585992956904485 24.071105260508833 -6.960335636808947 0.43067804108554536 1.010830544180406 0.4252406950067235 0.9997824430820481 0.002536927866837442 0.07958143840019237 0.020689963060635693 0.0035834416146258014 0.022799106470939537 1.0956311297250809e-07 6.960335636808947 -0.5855898491736824 SLSDSESDDSK(ub)SK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLSDSESDDSKSK 13 1 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 34331700.0 14244200.0 18815400.0 1272100.0 True False 13792025.66788087 26328487.341014765 938898.8478180243 1.0 1.9089644969505128 0.0680754858225467 23.717331028705505 -6.772454026910154 1.5651184390638906 1.5197257529885582 0.0567629361332839 0.7398293662181596 0.38334727177944905 0.26248469854152556 1.2692827009226015 0.19302442908543926 0.4584407441099291 1.688674607971538e-07 6.772454026910154 -1.4629628168552742 SLSDSESDDSK(ub)SK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLSDSESDDSKSK 13 1 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 36356200.0 13443700.0 14657000.0 8255500.0 True False 18414199.19233203 14009405.275782552 6305720.9273595 1.0 0.7607936206976785 0.34243796656578496 24.134315322031725 -6.962580926256066 0.39739131011957923 1.0236697979076204 0.06435025082592827 0.9998542672268492 0.003280547437440701 0.07879174602373448 0.01781693608073889 0.005385545006975945 0.03508605945686236 1.0899813667786261e-07 6.962580926256066 -0.9593195470816921 down SLSDSESDDSK(ub)SK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLSDSESDDSKSK 13 1 Q13185;S4R2Y4 Q13185 CBX3 Chromobox protein homolog 3 1 29315700.0 14244200.0 13797300.0 1274200.0 True False 11844683.425053991 13722971.206350368 1540629.328764852 1.0 1.1585764442908961 0.13006927019308068 23.49773630413978 -6.867551921627088 1.147040482371582 1.0884766152873555 0.07259070231570858 0.9621743220229707 0.08793299414352539 0.1392198187381153 0.34388969099128336 0.059581468175899724 0.14048506055721025 1.3565883350908098e-07 6.867551921627088 -1.0158859129716469 down SLSEAMSVEK(ub)IAAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLSEAMSVEKIAAIK 15 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 1 18298600.0 5041200.0 4993200.0 8264200.0 True False 4881169.86541337 6987010.799194014 6099558.099314297 1.0 1.4314213583719049 1.2496098819535235 22.218795527924303 -10.387067286696826 5.109841340348675 0.9997487256713533 1.3405156201627395 0.8238515791179786 0.07422422443460343 0.0002126274793093709 2.550498424265833e-05 0.0719196926084594 0.02395576542668569 4.101405536158554e-11 10.387067286696826 0.3407668944913862 SLSEGHPTAQHEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLSEGHPTAQHEK 13 0 P49748-2;P49748;P49748-3;G3V1M7;J3QRJ8 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 4960220.0 527820.0 2599800.0 1832600.0 False True 691977.131416151 2211919.9739410295 1642980.1315404947 1.0 3.1965217830454487 2.374327209597359 19.400364834643213 -10.324220971340226 5.8408943362889305 0.9997983549421953 2.785424496321409 0.8627772325615183 0.33565952903886703 0.0008814822973051648 0.00010198683794237104 0.3250352227521763 0.10833364716361023 4.740007497941776e-11 10.324220971340226 1.7856261413792138 SLSEGHPTAQHEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLSEGHPTAQHEK 13 0 P49748-2;P49748;P49748-3;G3V1M7;J3QRJ8 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 4715740.0 1103500.0 920440.0 2691800.0 False True 1068469.996525361 1287976.4920311884 1986736.827730962 1.0 1.2054400181752014 1.859422196404001 20.027114965883605 -6.950110130796859 0.5576338265185248 0.9913385029908671 2.1046518553344837 0.9992098934999896 0.010300200643858911 0.0834415661470443 0.03577966794605918 0.0110730486739195 0.05433611750475613 1.1217339627292924e-07 6.950110130796859 1.1133133523436167 SLSEGHPTAQHEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLSEGHPTAQHEK 13 0 P49748-2;P49748;P49748-3;G3V1M7;J3QRJ8 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 4154020.0 527820.0 2007900.0 1618300.0 False True 722969.3177991698 1919184.3387626274 1236090.869934695 1.0 2.654586151186776 1.7097418099256916 19.463574896166104 -10.122100634739965 4.805650008300239 0.9999285833335839 2.1821639805651185 0.6760867186837156 0.3857310871048809 134544850.72456372 14.661039630161405 106325.11527423195 0.1320460109568456 7.549172779255775e-11 10.122100634739965 1.1822353972315347 SLSEGHPTAQHEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLSEGHPTAQHEK 13 0 P49748-2;P49748;P49748-3;G3V1M7;J3QRJ8 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 1776330.0 1103500.0 385270.0 287560.0 False True 917609.1433388387 383194.47403989243 347687.46647278406 1.0 0.4176009762125845 0.3789058435138065 19.80752024131788 -13.999999999999998 0.3852878781344698 9.935915152339984 0.3758163920288271 0.9998159032137995 0.0038548048673053207 24.717299698896515 0.2029631610163469 183.59657990768784 0.01032467874843482 1.0000000000000041e-14 13.999999999999998 -9.560098760311156 SLSGLILK(ub)NNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLSGLILKNNVK 12 1 Q92973-2;Q92973;E7EW37;K7ENW1;K7ESC1;O14787-2;O14787;A0A075B780 Q92973-2;O14787-2 TNPO1;TNPO2 Transportin-1;Transportin-2 1 26979100.0 10435000.0 14661300.0 1882800.0 True False 13680386.052683732 12473891.18929979 1687985.917092898 1.0 0.9118084198254581 0.1233873013957643 23.705605607040155 -6.966412144486196 0.7943677456592897 1.0104080599165923 6.32606497303946e-23 0.9960888198846708 0.024646807030938907 0.08551764246755396 0.0859937915461098 0.022258610748774804 0.06486792913308242 1.0804081597252336e-07 6.966412144486196 -1.0104080599165923 down SLSGLILK(ub)NNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLSGLILKNNVK 12 1 Q92973-2;Q92973;E7EW37;K7ENW1;K7ESC1;O14787-2;O14787;A0A075B780 Q92973-2;O14787-2 TNPO1;TNPO2 Transportin-1;Transportin-2 1 29805200.0 6676500.0 12054500.0 11074200.0 True False 6464558.162031328 16867924.713387035 8173534.80112126 1.0 2.6092927452425774 1.2643609348473908 22.624120337777416 -6.602133131915104 2.1832147127565764 2.0808239226900405 1.2688701962347901 0.026537883966718634 0.6952190317789139 0.634695234957455 5.720794924429695 0.26406197305233714 0.7727889755301501 2.4995790043873284e-07 6.602133131915104 -0.8119537264552503 SLSGLILK(ub)NNVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLSGLILKNNVK 12 1 Q92973-2;Q92973;E7EW37;K7ENW1;K7ESC1;O14787-2;O14787;A0A075B780 Q92973-2;O14787-2 TNPO1;TNPO2 Transportin-1;Transportin-2 1 37162200.0 14956100.0 9637600.0 12568500.0 True False 22689497.137370113 7917694.981087514 10084330.466030745 1.0 0.3489585923015849 0.4444492711749713 24.435521299424448 -10.784458776198987 7.178222419698097 1.0171130590896365 0.3967039317382781 0.9815567414342415 0.03898390640529372 0.010165827053602056 0.00030524991682669497 0.03594031898264521 0.012582001689817608 1.6426355733947248e-11 10.784458776198987 -0.6204091273513583 SLSGLILK(ub)NNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLSGLILKNNVK 12 1 Q92973-2;Q92973;E7EW37;K7ENW1;K7ESC1;O14787-2;O14787;A0A075B780 Q92973-2;O14787-2 TNPO1;TNPO2 Transportin-1;Transportin-2 1 20065600.0 10435000.0 6750700.0 2879900.0 True False 14293101.495271737 6452431.752420374 2199726.9334022906 1.0 0.45143678260137493 0.15390130225619517 23.768815668563047 -8.744888811465023 0.2878181088946706 1.2234133360716817 7.836502328174246e-22 0.9988219415041794 0.012028417373120406 0.29565768359484196 0.08892313564955262 0.16830827860093783 0.10028122486268096 1.7993315229330836e-09 8.744888811465023 -1.2234133360716817 SLSGLILK(ub)NNVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLSGLILKNNVK 12 1 Q92973-2;Q92973;E7EW37;K7ENW1;K7ESC1;O14787-2;O14787;A0A075B780 Q92973-2;O14787-2 TNPO1;TNPO2 Transportin-1;Transportin-2 1 26811200.0 6676500.0 15881000.0 4253700.0 True False 5551805.569099914 15795445.900868308 5143129.003113366 1.0 2.845100698191263 0.9263885305600129 22.404525613211693 -6.655115104529363 1.9907710789385653 2.1924549515183407 0.934524893999224 0.21484338798774438 0.7865366275068325 0.49612374097988154 3.774591442569766 0.31982392513896907 0.8712242685331248 2.2125082331914486e-07 6.655115104529363 -1.2579300575191166 SLSLAGNK(ub)VTDQGVMPLSDALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLSLAGNKVTDQGVMPLSDALR 22 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 51029800.0 7631800.0 17149000.0 26249000.0 True False 10005363.706456339 14590436.046278436 23533005.278187536 1.0 1.4582614359999133 2.3520389631615264 23.254270276029278 -6.960533335745763 0.4278505821671349 0.9636777352343375 2.8807762820409635 0.999789471935522 0.008146140777012888 0.07951114924633677 0.020431385560885064 0.011631483551394714 0.07424898627368888 1.0951324915322119e-07 6.960533335745763 1.917098546806626 SLSLAGNK(ub)VTDQGVMPLSDALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLSLAGNKVTDQGVMPLSDALR 22 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 117348000.0 34370000.0 22705000.0 60273000.0 True False 33278943.163186826 31771224.905010823 44485693.14875853 1.0 0.9546945270833047 1.3367519794910019 24.98810628286365 -6.877313938132958 1.0947163826001642 0.9728066490105416 1.3624664184580184 0.9714513481101227 0.02879671313960259 0.13003380099788353 0.28691646817884564 0.020310657522070834 0.048796388841476475 1.3264352717984027e-07 6.877313938132958 0.3896597694474768 SLSLAGNK(ub)VTDQGVMPLSDALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLSLAGNKVTDQGVMPLSDALR 22 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 211033000.0 37993000.0 51020000.0 122020000.0 True False 57638158.66035281 41915082.3789206 97902693.51673405 1.0 0.7272106422746023 1.6985742742694128 25.780520911347896 -6.831742577552328 1.320263354753988 0.8544118029744426 1.7256259655902269 0.9092861254557786 0.12320359551028752 0.17867183870416484 0.6085062820721209 0.07325868452146264 0.16857141220291977 1.4731854553521104e-07 6.831742577552328 0.8712141626157842 SLSLAGNK(ub)VTDQGVMPLSDALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLSLAGNKVTDQGVMPLSDALR 22 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 56456800.0 7631800.0 26504000.0 22321000.0 True False 10453482.701640157 25332965.642992537 17049239.51542503 1.0 2.4233995851944905 1.630962618109082 23.31748033755217 -9.962424928448218 5.760653262304354 0.9999989172286147 2.0271811016523733 0.6913851970361793 0.32351103711506496 4.4987557414178925e-06 8.102593225653862e-07 0.3132385460985196 0.10441273825477491 1.0903729564778676e-10 9.962424928448218 1.0271821844237587 SLSLAGNK(ub)VTDQGVMPLSDALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLSLAGNKVTDQGVMPLSDALR 22 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 100152000.0 34370000.0 36033000.0 29749000.0 True False 28580177.849167094 35838883.07700949 35969378.35616513 1.0 1.2539769089664339 1.2585428455342305 24.768511558297927 SLSLAGNK(ub)VTDQGVMPLSDALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLSLAGNKVTDQGVMPLSDALR 22 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 152783000.0 37993000.0 40636000.0 74154000.0 True False 49182687.45399398 38374570.87808515 60658732.884293094 1.0 0.7802455063884246 1.2333350620791905 25.551647233440345 -6.774837037389123 1.556168002637321 0.8747362505993516 1.2363495579942543 0.7486585373272914 0.09274820490264804 0.258666893010072 1.2368636546539469 0.04696309343759935 0.11129259214750217 1.6794340828197418e-07 6.774837037389123 0.3616133073949027 SLSLHNNLLTYLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLSLHNNLLTYLPR 14 0 Q96CX6 Q96CX6 LRRC58 Leucine-rich repeat-containing protein 58 0 3334550.0 1169500.0 1328600.0 836450.0 False True 1533225.825454109 1130378.0588422385 749902.1777949606 1.0 0.7372547736126506 0.4891009304339466 20.548138773345386 -6.971816621750398 0.2103169670128833 1.1293987301654087 0.0900269786586703 0.9999932978618892 0.0005400082392835963 0.07571755584983045 0.006879474511019557 0.0074124005920964565 0.025695951906064208 1.0670465801634789e-07 6.971816621750398 -1.0393717515067384 down SLSLHNNLLTYLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLSLHNNLLTYLPR 14 0 Q96CX6 Q96CX6 LRRC58 Leucine-rich repeat-containing protein 58 0 5076100.0 2531200.0 1096200.0 1448700.0 False True 2450848.4415088305 1533918.37660748 1069242.009931586 1.0 0.6258723920370795 0.4362742272522254 21.22484984118942 -12.767894379248627 0.0989466563191303 2.4953785633348327 1.637559118913572e-22 0.999837624135874 0.0029845078905027353 7.774779176304676 0.08077294134012963 2.6809943254446886 0.3508830239358796 1.706497360008343e-13 12.767894379248627 -2.4953785633348327 SLSLHNNLLTYLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLSLHNNLLTYLPR 14 0 Q96CX6 Q96CX6 LRRC58 Leucine-rich repeat-containing protein 58 0 6046000.0 1169500.0 2373600.0 2502900.0 False True 1601895.7545491422 2268726.5035544476 1911766.5688435656 1.0 1.4162759949338817 1.1934400621354024 20.611348834868277 -10.12986170098826 4.221302162491804 0.999945297071974 1.3048580283761277 0.7139207085039865 0.0909723889294869 64013948.23763315 56587928.17762774 46873.16035233176 0.033292484653900084 7.41546345611858e-11 10.12986170098826 0.30491273130415375 SLSSNFILVK(ub)DLGQGIQNSVTDRPETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLSSNFILVKDLGQGIQNSVTDRPETR 27 2 Q92681 Q92681 RSC1A1 Regulatory solute carrier protein family 1 member 1 1 125263000.0 72686000.0 25088000.0 27489000.0 True False 70378622.71630488 35105769.232191674 20288806.24767682 1.0 0.49881296162476035 0.28828080835654707 26.068633945565395 -12.50084641534216 0.13750725755338392 2.6075353679081155 7.975216380996326e-19 0.9996517328819665 0.005571052024336503 6.795547135677483 0.10098563313259026 3.2713957687351995 0.23280500059014758 3.156120562020491e-13 12.50084641534216 -2.6075353679081155 SLSSNFILVK(ub)DLGQGIQNSVTDRPETR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLSSNFILVKDLGQGIQNSVTDRPETR 27 2 Q92681 Q92681 RSC1A1 Regulatory solute carrier protein family 1 member 1 1 243201000.0 186080000.0 31241000.0 25880000.0 True False 282296964.27021927 25665799.46295292 20764806.656393036 1.0 0.09091773101174831 0.07355660628541731 28.072638373696464 SLSSNFILVK(ub)DLGQGIQNSVTDRPETR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLSSNFILVKDLGQGIQNSVTDRPETR 27 2 Q92681 Q92681 RSC1A1 Regulatory solute carrier protein family 1 member 1 1 9678200.0 6386900.0 1651200.0 1640100.0 True False 8748309.529482622 1578244.5242117865 1252742.1589197875 1.0 0.18040565653203683 0.14319819785730364 23.0605728355206 -13.277808148841816 0.4484039724753563 9.999999999586175 0.14318588037032007 0.9998859509093366 0.004222859003514698 17.95364805469422 0.22700025097339585 156.23105676452124 0.008432844490121515 5.27462818572092e-14 13.277808148841816 -9.856814119215855 SLSSNFILVK(ub)DLGQGIQNSVTDRPETR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLSSNFILVKDLGQGIQNSVTDRPETR 27 2 Q92681 Q92681 RSC1A1 Regulatory solute carrier protein family 1 member 1 1 113217000.0 72686000.0 30589000.0 9942000.0 True False 60441629.53577424 30424210.985558912 12020826.233385805 1.0 0.5033651676705938 0.1988832254476347 25.84903922099967 -8.488739621418555 0.2699925200687171 1.208953889046916 2.7131676929125607e-15 0.9991546642577387 0.009599741697661255 0.16137131824840997 0.07178392796777576 0.12670587047898968 0.10451755151702893 3.2453413147310026e-09 8.488739621418555 -1.2089538890469134 down SLSSNFILVK(ub)DLGQGIQNSVTDRPETR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLSSNFILVKDLGQGIQNSVTDRPETR 27 2 Q92681 Q92681 RSC1A1 Regulatory solute carrier protein family 1 member 1 1 227589000.0 186080000.0 29828000.0 11681000.0 True False 240884228.1851707 28168045.579080734 9555177.857181355 1.0 0.11693603101913176 0.03966709621950081 27.843764695788913 -13.787167831111647 0.3468834703950478 9.99958345479742 0.02844121046933147 0.999742126619462 0.006995637239264148 17.51131878535916 0.18893190750748415 115.2016585529044 0.023314394083689936 1.6324209843796068e-14 13.787167831111647 -9.971142244328089 SLSTSLWSLTHLTALHLNDNYLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLSTSLWSLTHLTALHLNDNYLSR 24 0 H0Y9C1;H0Y9Z5;Q96LI5;D6RGK9;Q96LI5-2 H0Y9C1 CNOT6L CCR4-NOT transcription complex subunit 6-like 0 25147000.0 8918000.0 8058400.0 8170600.0 False True 11544526.800061025 7609942.956097083 6683634.637435672 1.0 0.6591818866111391 0.5789440098489218 23.46070570374224 -13.999999999989095 0.20318680917356735 2.9179691702383095 0.528440100000559 0.9994873429895837 0.004133023518441874 12.5957079877393 0.14291441399716384 9.614070711273794 0.049903363107546485 1.0000000000251098e-14 13.999999999989095 -2.3895290702377503 SLSTTNVFACSDRPTVIYSSNHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLSTTNVFACSDRPTVIYSSNHK 23 1 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 63811000.0 17122000.0 21977000.0 24712000.0 False True 22447107.809683863 18698117.26567505 22155039.294242427 1.0 0.8329855865711364 0.986988590337886 24.42002623757795 -10.429885997365801 6.959149340174835 1.0000097005492374 0.9099870884595702 0.31295166190465107 0.06287146301407537 9.463599283189597e-06 7.75214097968241e-07 0.060881591712934356 0.02029167743376745 3.716327701811765e-11 10.429885997365801 -0.09002261208966722 SLSTTNVFACSDRPTVIYSSNHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLSTTNVFACSDRPTVIYSSNHK 23 1 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 18870300.0 6585300.0 3008300.0 9276700.0 False True 6376253.256110979 4209529.878077257 6846853.974965385 1.0 0.6601886262975609 1.0738052112976195 22.604277501676282 -6.68841808403374 1.872209135562272 0.7866433482012324 1.0723426384479415 0.36297447571224695 0.1437629071538885 0.4200659100293705 2.8535217710912297 0.06146019308287722 0.16035629738039273 2.0491885283390373e-07 6.68841808403374 0.28569929024670915 SLSTTNVFACSDRPTVIYSSNHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLSTTNVFACSDRPTVIYSSNHK 23 1 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 16436700.0 6585300.0 2583700.0 7267700.0 False True 5475968.728254879 2569781.095275705 8787342.467951914 1.0 0.4692833766592129 1.6047101260113164 22.38468277711056 -6.779589508625346 1.5373248229481924 0.6993345623272543 1.6136121591717212 0.7659800817824107 0.22439702203028739 0.25121392808952653 1.172644958599626 0.114965663268036 0.2713803636580467 1.6611562761373898e-07 6.779589508625346 0.9142775968444669 SLSTTNVFACSDRPTVIYSSNHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLSTTNVFACSDRPTVIYSSNHK 23 1 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 33581800.0 9112800.0 14168000.0 10301000.0 False True 11796699.240143087 13379538.345327074 8426323.697185615 1.0 1.1341764397788265 0.7142950350477367 23.491879908881216 -6.820731495061366 1.3687084275257306 1.0722668618270135 0.7049839124880353 0.8860600282811457 0.05910402731490175 0.19253039358184848 0.7085155974804183 0.0339321690887378 0.0781932532098461 1.5110140581441057e-07 6.820731495061366 -0.3672829493389782 SLSVLSSSTIIANPDIPEAYK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLSVLSSSTIIANPDIPEAYKLR 23 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 36614700.0 16512000.0 8598700.0 11504000.0 True False 15987835.598211855 12032205.75162813 8490757.287397642 1.0 0.7525850311454204 0.5310760943993746 23.930471307027247 -6.972435225854832 0.1912742485065834 1.1476496135518321 0.12995217407229637 0.9999956700529941 0.0003985137145847374 0.07552018810517827 0.006111226702064416 0.0077358764931295355 0.02406231603131683 1.0655277731328989e-07 6.972435225854832 -1.0176974394795357 SLSVLSSSTIIANPDIPEAYK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLSVLSSSTIIANPDIPEAYKLR 23 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 123204000.0 34242000.0 33734000.0 55228000.0 True False 51947617.42552044 27713904.135055 44312161.592707664 1.0 0.5334971170677776 0.8530162457641092 25.63055424573349 -10.070912294214647 5.5978950690775084 1.0000019312550164 0.6932566814158535 0.5513360602079878 0.13044313806110028 3.1440750106896105e-06 5.217943987301226e-07 0.12630181947506822 0.04210034177809322 8.493519843796299e-11 10.070912294214647 -0.30674524983916285 SLSVLSSSTIIANPDIPEAYK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLSVLSSSTIIANPDIPEAYKLR 23 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 41135900.0 16512000.0 15762000.0 8861900.0 True False 13730459.605628384 15677086.977487944 10714882.317203926 1.0 1.1417743781178016 0.7803731721268592 23.710876582461523 -6.80028303275165 1.4546550697277303 1.0781942163166223 0.7753431162944017 0.8330295059400876 0.06075290281714958 0.22034574398278392 0.9204599785193047 0.03285490558839803 0.0763987329311471 1.583860642978017e-07 6.80028303275165 -0.3028511000222206 SLSVLSSSTIIANPDIPEAYK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLSVLSSSTIIANPDIPEAYKLR 23 1 P27694;I3L4R8 P27694 RPA1 Replication protein A 70 kDa DNA-binding subunit;Replication protein A 70 kDa DNA-binding subunit, N-terminally processed 1 139860000.0 34242000.0 53347000.0 52271000.0 True False 44326944.01072986 50378192.55421815 42758214.34575182 1.0 1.1365140024546587 0.9646100199328358 25.401680567825938 -6.695059706653244 1.8480731062293758 1.0851731383675793 0.9651586275607792 0.3944080026887977 0.0576774239537985 0.40586264054722637 2.6912073294563092 0.024929447207645443 0.0645157310254755 2.0180888984542393e-07 6.695059706653244 -0.12001451080680015 SLTATILTMSSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLTATILTMSSSR 13 0 Q7RTS1 Q7RTS1 BHLHA15 Class A basic helix-loop-helix protein 15 0 7233800.0 2668800.0 2032300.0 2532700.0 False True 3498822.6446959674 1729088.7618433519 2270640.499373903 1.0 0.4941916002700395 0.6489727345328794 21.738438105550262 -10.872307642529652 11.058145536828953 1.0165892543859836 0.5715821674014686 0.91083359109741 0.06318913345886204 0.022781198955703734 0.0002630621384179372 0.05393254226624771 0.020394205128954214 1.3418141193712088e-11 10.872307642529652 -0.44500708698451497 SLTAVFMWPGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLTAVFMWPGK 11 0 Q99808;Q99808-2 Q99808 SLC29A1 Equilibrative nucleoside transporter 1 0 2009590.0 641150.0 837200.0 531240.0 False True 840553.8589054323 712293.023380041 476272.3808139105 1.0 0.8474091408105456 0.5666173270968163 19.68098073826033 -6.961640840644346 0.41166085271125974 1.013584000423556 0.38999384004533877 0.9998262866175944 0.00236567218809077 0.0791201628273507 0.019003756617406865 0.0036175302751331696 0.02343155341901099 1.0923433254583788e-07 6.961640840644346 -0.6235901603782171 SLTGSSDLYK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLTGSSDLYKR 11 1 H0YCK1 H0YCK1 PUM1 1 70372000.0 7134000.0 47967000.0 15271000.0 True False 10822799.565260876 39406914.082118385 12252680.15648292 1.0 3.641101717212529 1.1321174417580169 23.367570397802695 -6.634086682367217 2.0653610390128057 2.734748597053495 1.14229078254583 0.13251566640984025 1.131715695087659 0.5484165175626232 4.463259386684066 0.4473161974680358 1.2536610255661729 2.3222732393916307e-07 6.634086682367217 -1.5924578145076649 SLTGSSDLYK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLTGSSDLYKR 11 1 H0YCK1 H0YCK1 PUM1 1 22822300.0 8866900.0 8476500.0 5478900.0 True False 7373220.220272908 8430835.412046487 6624512.658428624 1.0 1.1434400655585508 0.8984558253413226 22.813863416752458 -6.747978701153812 1.657066808115254 1.0845458922718345 0.8980348213782071 0.6403687719464644 0.060269538137595884 0.3035664200940797 1.6393344953740367 0.028738083783732632 0.0699240808791027 1.7865751906489555e-07 6.747978701153812 -0.1865110708936274 SLTGSSDLYK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLTGSSDLYKR 11 1 H0YCK1 H0YCK1 PUM1 1 42787000.0 7134000.0 20578000.0 15075000.0 True False 9235103.632163625 19432816.210484218 12331504.682562219 1.0 2.104233691845583 1.3352860101769275 23.138696719895144 -10.209473999230797 4.889723505209889 0.9999018853086955 1.7197598510125922 0.5387897575943124 0.3139215765019973 0.0003358150341270359 5.429061026416418e-05 0.3039943093276761 0.10131775314995937 6.17342250435388e-11 10.209473999230797 0.7198579657038967 SLTINGK(ub)EQLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLTINGKEQLLR 12 1 O75190-2 O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 185096000.0 42811000.0 75404000.0 66881000.0 True False 56125635.58231376 64154017.12248992 59960795.68785314 1.0 1.1430430400810652 1.0683317002248418 25.742156541637886 -10.273082554264564 3.8586038719478735 0.9998348075654294 1.1056873701756833 0.7273837480933276 0.030500776848838455 21765726.8668548 10722061.257758606 34050.73758201936 0.0111621414732762 5.332335244422612e-11 10.273082554264564 0.10585256261025389 SLTINGK(ub)EQLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLTINGKEQLLR 12 1 O75190-2 O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 306838000.0 81318000.0 104610000.0 120910000.0 True False 78736604.6012227 146381318.53394315 89240043.7777512 1.0 1.8591266320832687 1.1333996967449294 26.23053116397548 -10.233019375752587 4.5191690407703184 0.9998315099564535 1.496263164417624 0.3840358506920897 0.2962767807126547 0.0005066417072212956 8.598585035165046e-05 0.2869659185266925 0.095622919794913 5.847639947150618e-11 10.233019375752587 0.49643165446117055 SLTINGK(ub)EQLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLTINGKEQLLR 12 1 O75190-2 O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 642393000.0 209810000.0 150270000.0 282313000.0 True False 318297109.16559917 123453144.43513118 226513711.8078163 1.0 0.3878550601944132 0.7116423784105714 28.24579881330367 -10.601314067029966 6.640524727483026 1.0010138440585834 0.5497487193025464 0.7205356135558698 0.13218561913562543 0.0019880707223156814 0.00011936021612466964 0.12824547508319747 0.042662725126699455 2.504297575025138e-11 10.601314067029966 -0.451265124756037 SLTINGK(ub)EQLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLTINGKEQLLR 12 1 O75190-2 O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 167138000.0 42811000.0 45196000.0 79131000.0 True False 58639383.62377377 43199091.27681444 60441887.55410134 1.0 0.7366907461711538 1.0307387939459307 25.805366603160778 -6.670653918976527 1.9352536821657143 0.832024577195764 1.029548914561096 0.28189698686916953 0.11183127470889957 0.4595952150316125 3.319150163615866 0.046513149217264085 0.12415661143994723 2.1347453735643113e-07 6.670653918976527 0.19752433736533215 SLTINGK(ub)EQLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLTINGKEQLLR 12 1 O75190-2 O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 203443000.0 81318000.0 76807000.0 45318000.0 True False 67619519.99821262 76393225.44600414 54793784.27324248 1.0 1.1297510755477624 0.8103249516513995 26.010936439409758 -6.796410553078738 1.470377915320009 1.0719172509356012 0.8062888941966793 0.8215167950896395 0.0554148337062542 0.22591197025471893 0.9645762149084746 0.02965322477035593 0.06912314348583302 1.5980466274881422e-07 6.796410553078738 -0.26562835673892193 SLTINGK(ub)EQLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLTINGKEQLLR 12 1 O75190-2 O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 626699000.0 209810000.0 175400000.0 241489000.0 True False 271603180.9734021 165638835.8110083 197540479.88638562 1.0 0.6098560231046382 0.727312836242999 28.016925135396118 -10.560694748473404 9.384676194112847 1.0000249824698708 0.6685844296738194 0.9139059053645454 0.04795154316706923 2.5066375118687035e-05 1.1733666462743334e-06 0.04643236800530306 0.01547629400925043 2.749826237831735e-11 10.560694748473404 -0.33144055279605145 SLTNDWEDHLAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLTNDWEDHLAVK 13 0 P08238;P07900;P07900-2 P08238;P07900 HSP90AB1;HSP90AA1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha 0 249293400.0 38730400.0 117430000.0 93133000.0 False True 50775929.4657271 99909901.73855485 83496490.55481866 1.0 1.9676626856430537 1.644410874077202 25.597641407857967 -10.347357288435097 5.369192147282165 0.9997475410699583 1.8060367798601513 0.8923600251814114 0.13196699946118773 0.0003989316867441767 4.8491600762384576e-05 0.12781525662618706 0.042592165930166744 4.494099790096684e-11 10.347357288435097 0.806289238790193 SLTNDWEDHLAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLTNDWEDHLAVK 13 0 P08238;P07900;P07900-2 P08238;P07900 HSP90AB1;HSP90AA1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha 0 245995200.0 79115000.0 39932200.0 126948000.0 False True 76603537.63036147 55877335.70367196 93696510.44163387 1.0 0.7294354468758272 1.223135554049108 26.190907683044923 -6.757875368627613 1.620232787923849 0.8424314159615215 1.2247682697267626 0.6823593223756661 0.11376866322695715 0.28648408924997526 1.4817102335622179 0.055412887489545995 0.13345923059657927 1.7463232309757383e-07 6.757875368627613 0.38233685376524107 SLTNDWEDHLAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLTNDWEDHLAVK 13 0 P08238;P07900;P07900-2 P08238;P07900 HSP90AB1;HSP90AA1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha 0 828243000.0 46284000.0 715340000.0 66619000.0 False True 70216211.81364387 587681988.0230706 53451725.44985504 1.0 8.3696054350354 0.7612447904725717 26.065300828685803 -6.653371566012661 1.9960958640157354 5.769092678569662 0.7927861310667796 0.20811141406019018 3.142780850712953 0.5002253180123685 3.8239404215139614 1.275102091063198 3.4826416146768304 2.2214085238752154e-07 6.653371566012661 -4.976306547502883 SLTNDWEDHLAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLTNDWEDHLAVK 13 0 P08238;P07900;P07900-2 P08238;P07900 HSP90AB1;HSP90AA1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha 0 255707400.0 38730400.0 110238000.0 106739000.0 False True 53050075.5297051 105367320.65168305 81529446.55870937 1.0 1.9861860628771997 1.5368394058752546 25.66085146938086 -10.189580511863944 4.807047775252956 0.9999033157704963 1.7615127343782846 0.7929346806376087 0.18344500455598536 128826136.87987867 25.10784366902939 138054.435281517 0.06279810440919001 6.462781723443352e-11 10.189580511863944 0.7616094186077883 SLTNDWEDHLAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLTNDWEDHLAVK 13 0 P08238;P07900;P07900-2 P08238;P07900 HSP90AB1;HSP90AA1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha 0 139715400.0 79115000.0 40326500.0 20273900.0 False True 65787627.888765 40109253.14031648 24513078.75407766 1.0 0.6096777529071877 0.3726092510209496 25.9713129584792 -8.85291963286938 0.15974904211862953 1.4534766775903067 1.4079350797398248e-09 0.9998267653509751 0.003404519374050998 0.35953859824690565 0.04818305842904296 0.23688127740215054 0.1579397913621817 1.4030733222844304e-09 8.85291963286938 -1.4534766761823716 SLTNDWEDHLAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLTNDWEDHLAVK 13 0 P08238;P07900;P07900-2 P08238;P07900 HSP90AB1;HSP90AA1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha 0 195072000.0 46284000.0 83424000.0 65364000.0 False True 59915550.3940373 78781381.06441027 53468422.69127669 1.0 1.314873693829081 0.8923964202888769 25.836427150778253 -6.707176141013611 1.805415220155772 1.194134157259123 0.8934750792814926 0.45163286244323975 0.13274613160349602 0.3807706076159514 2.4176053975239085 0.05855323562196508 0.14925629158864898 1.9625641392780643e-07 6.707176141013611 -0.3006590779776305 SLTNDWEDHLAVK(ub)HFSVEGQLEFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLTNDWEDHLAVKHFSVEGQLEFR 24 1 P08238;P07900;P07900-2 P08238;P07900 HSP90AB1;HSP90AA1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha 1 215709200.0 31184200.0 75718000.0 108807000.0 True False 47308711.270396516 62205531.312565826 87301248.75819771 1.0 1.3148853486417207 1.8453525030352407 25.495602525354258 -6.963256523809519 0.38680976204286766 0.9662399893732809 2.212961049465917 0.9998725719504091 0.003937779332722183 0.07855768199699689 0.016977693326158057 0.006862827453458893 0.04468365353755935 1.0882870872024149e-07 6.963256523809519 1.2467210600926362 SLTNDWEDHLAVK(ub)HFSVEGQLEFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLTNDWEDHLAVKHFSVEGQLEFR 24 1 P08238;P07900;P07900-2 P08238;P07900 HSP90AB1;HSP90AA1 Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha 1 105923200.0 31184200.0 40648000.0 34091000.0 True False 40368561.63248071 38385903.067536265 27886787.8031992 1.0 0.9508860735986889 0.6908045933635986 25.266728847446707 -6.938533052027531 0.6730733087669981 1.0030066529492714 0.6235956629334328 0.9979653586636911 0.006119649275474741 0.08844234635836208 0.05770557087217718 0.005892774478885845 0.02253322679726552 1.1520383804864944e-07 6.938533052027531 -0.37941099001583856 SLTNSHLEK(ub)KK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLTNSHLEKKK 11 2 Q9H2H9;F8VX04;F8VX12 Q9H2H9 SLC38A1 Sodium-coupled neutral amino acid transporter 1 2 2232730.0 257700.0 812630.0 1162400.0 True False 337847.19557034987 691388.7716069309 1042125.9985281399 1.0 2.046454079453689 3.084607515444473 18.366011353965217 -6.971223518952904 0.22706939750326408 0.5620013218851828 4.598619704005118 0.9999904168414071 0.002634529806549855 0.07590765372586857 0.007594112623075615 0.027260652690971752 0.10370513829757157 1.0685048088066149e-07 6.971223518952904 4.0366183821199355 SLTNSHLEKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLTNSHLEKK 10 1 Q9H2H9;F8VX04;F8VX12 Q9H2H9 SLC38A1 Sodium-coupled neutral amino acid transporter 1 1 9497100.0 1962500.0 2317500.0 5217100.0 True False 1900201.5117181905 3242889.8356028427 3850585.0003548595 1.0 1.7066031237237431 2.0264087659172016 20.857720990270344 -10.239544812261554 0.17826383142282773 2.4716868575010436e-15 2.3701077593508195 0.9995381656360416 0.009215758620152496 1.8755158609711682 0.08722155493874707 1.0882324410395423 0.22728326148963884 5.760433770072111e-11 10.239544812261554 2.370107759350817 SLTNSHLEKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLTNSHLEKK 10 1 Q9H2H9;F8VX04;F8VX12 Q9H2H9 SLC38A1 Sodium-coupled neutral amino acid transporter 1 1 7864200.0 1962500.0 2747100.0 3154600.0 True False 1631905.70349114 2732300.827043344 3814212.2747775903 1.0 1.67430067876969 2.3372749213498283 20.63812626570462 -6.971333559056056 0.2240571312078784 0.7095047009927175 3.3208805974089493 0.9999909986292236 0.0016379547321597005 0.07587231536694092 0.007462771534635776 0.017806488296534997 0.06663082230349865 1.0682341088789724e-07 6.971333559056056 2.6113758964162317 SLTQMEDVLK(ub)ALQMK ddPTM_RPMI8226_Bortezomib_1h_R1 3 SLTQMEDVLKALQMK 15 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 25488500.0 5842100.0 15039500.0 4606900.0 True False 7659049.674976878 12795665.223511834 4130222.1805052436 1.0 1.6706596466291312 0.5392603985843338 22.86873396483572 -6.7461042216292055 1.6641830312152202 1.396195555055676 0.537654353208902 0.6320561110346401 0.28177901464690003 0.306897836200114 1.6710043107059003 0.13382451305831877 0.32623991449143147 1.7943029798220125e-07 6.7461042216292055 -0.858541201846774 SLTQMEDVLK(ub)ALQMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLTQMEDVLKALQMK 15 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 55232600.0 19652000.0 26588000.0 8992600.0 True False 19028158.01696095 37204727.054588325 6637168.2877826905 1.0 1.9552458530891692 0.34880771338279726 24.18163257535501 -6.745613395772014 1.6659274680381706 1.564646336900297 0.34662755051972977 0.6299114795414935 0.4013459130894244 0.30777672454590055 1.6791273156543538 0.19042089071137389 0.464467127205657 1.7963319905198568e-07 6.745613395772014 -1.2180187863805672 SLTQMEDVLK(ub)ALQMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLTQMEDVLKALQMK 15 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 54228900.0 30003000.0 18860000.0 5365900.0 True False 45516744.51310941 15494285.646147411 4305327.513042479 1.0 0.3404084763066668 0.09458777333696369 25.439894039897585 -9.597759707679804 0.29169857415077916 1.3892782829508559 2.368814620258427e-16 0.9987351879745571 0.013595573163512047 0.9975569163295517 0.12246240060715285 0.44858037073113266 0.08833744023604716 2.5248773843583283e-10 9.597759707679804 -1.3892782829508556 SLTQMEDVLK(ub)ALQMK ddPTM_RPMI8226_Carfilzomib_1h_R1 3 SLTQMEDVLKALQMK 15 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 31566000.0 5842100.0 10744200.0 14979700.0 True False 8002082.246816206 10269485.717681851 11441803.376605527 1.0 1.283351682840773 1.4298532586512573 22.93194402635861 -12.124783407736334 0.10119341100409074 4.359173079340342e-11 1.7700506417994974 0.999844599671403 0.0022242535432093207 5.9820466554276495 0.0757171277520282 1.5327079094502385 0.25828553068255505 7.502682914342463e-13 12.124783407736334 1.7700506417559057 SLTQMEDVLK(ub)ALQMK ddPTM_RPMI8226_Carfilzomib_2h_R1 3 SLTQMEDVLKALQMK 15 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 76878200.0 35728700.0 31707600.0 9441900.0 True False 29709997.09978287 31536784.865334187 11416157.635586945 1.0 1.0614873087808099 0.38425307135658987 24.824445128552515 -6.884719509667965 1.0530934660886437 1.0411266649915916 0.33168676946074377 0.9772984993755848 0.046073526276209496 0.1235331203074153 0.2477019985047308 0.03354504289197301 0.08218853999398537 1.3040087042905036e-07 6.884719509667965 -0.7094398955308479 down SLTQMEDVLK(ub)ALQMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLTQMEDVLKALQMK 15 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 49324000.0 30003000.0 13810000.0 5511000.0 True False 38839474.94754775 13041461.36003434 4508054.547635179 1.0 0.33577851857283547 0.1160688849095734 25.211020361990034 -10.51504557800667 0.24255499935982336 1.7621594905214573 2.1992664536253623e-22 0.9991595300104755 0.010893760714876051 2.2075265078217936 0.1226893147556535 1.1216027180639039 0.10283197346518766 3.054600524502892e-11 10.51504557800667 -1.7621594905214573 SLTYK(ub)ESGVDIAAGNMLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLTYKESGVDIAAGNMLVK 19 1 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 21049600.0 3651500.0 5094100.0 12304000.0 True False 3535585.1312300423 7128200.6953805685 9081213.287912088 1.0 2.016130408632147 2.568517784424753 21.75351756683869 -9.172069167424423 0.18700114920846642 4.001525591583938e-21 3.206615673794033 0.9996246319014943 0.012585752634410965 0.6190061519239217 0.06644433978311536 0.6948109985544231 0.3332326492092842 6.728694839451886e-10 9.172069167424423 3.206615673794033 SLTYK(ub)ESGVDIAAGNMLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLTYKESGVDIAAGNMLVK 19 1 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 51141900.0 5672900.0 11117000.0 34352000.0 True False 8606204.04454282 9133084.492482545 27562312.14298356 1.0 1.0612210035008198 3.202609652331074 23.03694561488118 -6.913015054641869 0.8749419137697714 0.939852080500088 3.497975649150302 0.9920106922580535 0.09154556698741102 0.10245809543762247 0.12819892658175883 0.07608526870256095 0.21469026964591392 1.221757307709835e-07 6.913015054641869 2.5581235686502137 up SLTYK(ub)ESGVDIAAGNMLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLTYKESGVDIAAGNMLVK 19 1 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 10568100.0 1543300.0 3112100.0 5912700.0 True False 2113899.716114316 2974597.131661523 4516242.035878923 1.0 1.4071609494935293 2.1364504670924003 21.011475505885684 -6.962142939053542 0.4040998294229436 0.961678637970687 2.6087392130742746 0.9998416051945402 0.005916763108730102 0.0789443217430812 0.018366829007830186 0.009382145150548691 0.06101174324528607 1.0910811705271012e-07 6.962142939053542 1.6470605751035876 up SLTYK(ub)ESGVDIAAGNMLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLTYKESGVDIAAGNMLVK 19 1 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 14894100.0 3651500.0 4864000.0 6378600.0 True False 3036384.038877903 4837796.666571597 7712335.768685835 1.0 1.5932756214722452 2.5399737549456796 21.533922842272965 -6.964208831276818 0.37138002240471435 0.9283277358936215 3.237946378545525 0.9998958966061723 0.006470670036191732 0.07823046727157776 0.015812855955156552 0.01245263305724018 0.08034335218260369 1.08590333949742e-07 6.964208831276818 2.3096186426519036 SLTYLSILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLTYLSILR 9 0 P09661;H0YMA0;H0YKK0 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 0 88613000.0 27350000.0 30737000.0 30526000.0 False True 35856114.85777679 26151159.411887627 27367462.346068475 1.0 0.7293361122814379 0.7632578837562703 25.095715839560242 -10.148897555254907 7.746209773240742 1.000000064789915 0.7462969981203696 0.9867693005391173 0.01384850521410618 1.5494042205573602e-08 1.7024076020928782e-09 0.013408760912710507 0.004469585838674983 7.097451684045707e-11 10.148897555254907 -0.25370306666954534 SLTYLSILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLTYLSILR 9 0 P09661;H0YMA0;H0YKK0 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 0 80898000.0 34102000.0 16079000.0 30717000.0 False True 33019450.67649101 22499428.550877273 22671296.20975257 1.0 0.6813992386280454 0.6866042815755848 24.97681278346651 -9.775701961309794 5.939432156240953 1.0000000169063388 0.6840017601008961 0.9997965510688815 0.002124949888787914 2863310.3889293442 1.317935040929195 0.6634164696155973 0.0007274268667171043 1.676092715894395e-10 9.775701961309794 -0.3159982568054427 SLTYLSILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLTYLSILR 9 0 P09661;H0YMA0;H0YKK0 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 0 62838000.0 15901000.0 22533000.0 24404000.0 False True 24122979.518813223 18511810.098867457 19580538.70334682 1.0 0.7673931855901266 0.8116965272915889 24.52390477507893 -10.481845336690707 6.120943068553446 1.0001417634747505 0.789544856440859 0.9678326375314734 0.018086763511458413 3.501354473048016e-05 2.9640026792857394e-06 0.017524159953175713 0.005837477822222533 3.297271154819849e-11 10.481845336690707 -0.21059690703389145 SLTYLSILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLTYLSILR 9 0 P09661;H0YMA0;H0YKK0 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 0 113790830.0 27350000.0 35118830.0 51322000.0 False True 37462034.10595906 33567163.96815934 39200800.60976849 1.0 0.8960315361738416 1.0464140975071305 25.158925901083133 -6.720704208560836 1.7566478570847732 0.9367949795609718 1.0461911068182987 0.5158930755722628 0.0437465661002175 0.35395429946374685 2.1349373839729897 0.019770192661449276 0.049592014299228396 1.9023735167777016e-07 6.720704208560836 0.10939612725732695 SLTYLSILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLTYLSILR 9 0 P09661;H0YMA0;H0YKK0 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 0 69219000.0 34102000.0 15561000.0 19556000.0 False True 28357323.974754013 15477169.80438335 23645069.183272246 1.0 0.5457909151851699 0.8338258294161678 24.757218058900786 -10.450585581572918 6.276727906638276 1.0001104346246097 0.6898083723006694 0.6072814560599993 0.11758976132871035 0.00018178718967687646 1.5912071556416702e-05 0.11389603980572473 0.03795193227588335 3.543352984928672e-11 10.450585581572918 -0.3103020623239403 SLTYLSILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLTYLSILR 9 0 P09661;H0YMA0;H0YKK0 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 0 67605000.0 15901000.0 31238000.0 20466000.0 False True 20584157.95556968 29499577.839591105 16741397.998893406 1.0 1.4331204561908777 0.8133146876850263 24.29503109717138 -6.71883523671091 1.7634010603948935 1.263836403594024 0.8143394602542255 0.5070028260736199 0.18228610634479991 0.3576163030456593 2.1726306185884376 0.08209670842555111 0.20638452801181115 1.910577959007793e-07 6.71883523671091 -0.4494969433397984 SLVALLVETQMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLVALLVETQMK 12 0 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 0 7168400.0 3460300.0 1642600.0 2065500.0 False True 3350454.6705724588 2298498.7460458414 1524483.5863282185 1.0 0.6860259194771078 0.45500797241579904 21.675925457870846 -7.6700432931639995 0.15841179467076266 1.2966230033720205 1.1990620008581945e-15 0.9999693992178802 0.001235511145057082 0.13475137561369996 0.018452974186168595 0.053438734563950444 0.08342135598494933 2.1377489748209706e-08 7.6700432931639995 -1.2966230033720194 down SLVALLVETQMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 SLVALLVETQMK 12 0 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 0 80004900.0 15071200.0 40192700.0 24741000.0 False True 22864112.25230725 33019998.65800155 19850930.505634483 1.0 1.4441845934634725 0.8682134817471996 24.44658156874642 -6.700689199817035 1.8279575648071194 1.2756197231480078 0.8698760752395164 0.42112019565640724 0.18747027104698458 0.3940564891528537 2.560247615764002 0.08179522858988902 0.21021242498091022 1.992098462035277e-07 6.700689199817035 -0.4057436479084914 SLVALLVETQMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLVALLVETQMK 12 0 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 0 2934390.0 0.0 701590.0 2232800.0 False True 0.0 670591.4339521242 1705458.6259594546 0.0 SLVALLVETQMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLVALLVETQMK 12 0 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 0 6818400.0 3460300.0 1478400.0 1879700.0 False True 2877392.767281726 1470435.565760577 2272736.5792491743 1.0 0.5110305351708025 0.789859696977076 21.456330733305123 -10.183572424613148 5.5712259602628675 1.0000098858239408 0.6504451160739129 0.6769531475210675 0.11383152863898052 1.3977885363654947e-05 2.048339386236607e-06 0.1102200191235252 0.036738967890994526 6.552809995490052e-11 10.183572424613148 -0.3495647697500279 SLVALLVETQMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SLVALLVETQMK 12 0 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 0 52543300.0 15071200.0 20692500.0 16779600.0 False True 19509965.497766275 19540944.184830613 13725884.973235216 1.0 1.0015878391516317 0.703531996240932 24.21770789083887 -6.90569901888697 0.9245131241922571 1.0105299988908574 0.6683552066616235 0.989195113709482 0.014566249343411844 0.10733174417828743 0.1546977933320689 0.011677577565544323 0.03135167835420074 1.24251311388254e-07 6.90569901888697 -0.34217479222923386 SLVASLAEPDFVVTDFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLVASLAEPDFVVTDFAK 18 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 11092500.0 4626900.0 4680100.0 1785500.0 False True 6065910.706963334 3981847.3228869196 1600753.5877253904 1.0 0.6564302567652334 0.2638933649135014 22.532292830298235 -7.351169073796989 0.339932226870861 1.0566257471104223 5.3949765290703e-11 0.9996945637264352 0.005255877308807769 0.10963367091318325 0.028116271861292477 0.014209501523491692 0.05429498229462313 4.4548278515490784e-08 7.351169073796989 -1.0566257470564726 down SLVASLAEPDFVVTDFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLVASLAEPDFVVTDFAK 18 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 45793000.0 15253000.0 9159000.0 21381000.0 False True 14768801.86407008 12816236.463554032 15780674.683749046 1.0 0.8677912116035426 1.0685142118495528 23.816049454777502 -6.72904849619914 1.7266930803446183 0.9203539762708605 1.0683746050618212 0.5548759754339674 0.0555815907508527 0.33801258232793346 1.9738833801095719 0.025513615364730447 0.06337877015014509 1.8661712901491567e-07 6.72904849619914 0.14802062879096078 SLVASLAEPDFVVTDFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLVASLAEPDFVVTDFAK 18 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 81919200.0 9385200.0 72534000.0 0.0 False True 14238034.550026141 59589740.98927139 0.0 1.0 4.185250483829033 0.0 23.76324667142639 -6.703417361292893 1.8198210723583639 2.971575731302719 0.012318780401566712 0.4330061592453195 1.3437616406728454 0.3886288465340108 2.504756935656967 0.5887010155440429 1.506991252247469 1.9796236734499106e-07 6.703417361292893 -2.9592569509011524 SLVASLAEPDFVVTDFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLVASLAEPDFVVTDFAK 18 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 16902400.0 4626900.0 3204500.0 9071000.0 False True 6337589.9672709955 3062914.594135585 6928616.623109193 1.0 0.48329327235641506 1.0932573200365465 22.595502891821127 -6.68218547912576 1.893850651104522 0.6737250159833215 1.090992929867309 0.3342918711888869 0.21888735239952492 0.43367682793994067 3.009099964964933 0.09267149358225593 0.2437569486011631 2.0788086768252025e-07 6.68218547912576 0.41726791388398743 SLVASLAEPDFVVTDFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLVASLAEPDFVVTDFAK 18 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 30739800.0 15253000.0 7374300.0 8112500.0 False True 12683545.322471507 7334573.182216061 9808786.242038049 1.0 0.5782746854872949 0.773347356173338 23.59645473021178 -10.230755294573868 6.012294169369289 1.0000076890502119 0.6758110208303151 0.7864387184449673 0.07963808432380237 8.20812456741666e-06 1.0502063280006952e-06 0.07711107195669395 0.02570308119249496 5.878204696579593e-11 10.230755294573868 -0.3241966682198968 SLVASLAEPDFVVTDFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLVASLAEPDFVVTDFAK 18 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 35288200.0 9385200.0 12606000.0 13297000.0 False True 12149326.409949841 11904465.018435411 10877082.438741593 1.0 0.9798456817067737 0.8952827565677774 23.53437299351884 -6.943781220526377 0.6234258743103339 1.0009237183592177 0.8696985748285169 0.9986180477723262 0.0016864593313839068 0.0860839253884791 0.047072652917602945 0.0016931252377718011 0.007165883323666864 1.1382005194465957e-07 6.943781220526377 -0.1312251435307008 SLVASLAEPDFVVTDFAK(ub)FSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLVASLAEPDFVVTDFAKFSR 21 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 26432800.0 8948900.0 6688900.0 10795000.0 True False 13576135.552223612 5495213.53438577 8661363.518383412 1.0 0.4047700844800211 0.6379844606784868 23.694569539003254 -10.248414266163698 5.563795352030318 1.000031500982882 0.5213772725792469 0.8488476162133535 0.09520937039468025 3.7205331668059675e-05 5.025984596509099e-06 0.09219212759598162 0.030728692161782072 5.643983479177686e-11 10.248414266163698 -0.47865422840363503 SLVASLAEPDFVVTDFAK(ub)FSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLVASLAEPDFVVTDFAKFSR 21 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 21673300.0 8948900.0 5404200.0 7320200.0 True False 11584527.45919109 5103451.519326398 5987998.711594823 1.0 0.4405403273723826 0.5168962422238451 23.465695861095703 -10.624602528518666 6.55679069080638 1.0018016475905405 0.47871828479836276 0.9841631513831609 0.03117217170491387 0.0008232021906289302 4.7130945480194195e-05 0.030264196324401013 0.010060775156520789 2.3735450085645183e-11 10.624602528518666 -0.5230833627921777 SLVEASSSGVSVLSLCEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLVEASSSGVSVLSLCEK 18 0 Q9UQ80;F8VR77;F8W0A3;H0YIN7 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 11830000.0 4579300.0 4888000.0 2362700.0 False True 6003506.646004279 4158729.4532747655 2118230.468618753 1.0 0.6927167234907066 0.3528322018313367 22.517373993883112 -7.105297181302125 0.2803297207485122 1.080806102444699 2.1690103572712785e-11 0.9999672091391145 0.001513554727576888 0.07695599361123164 0.011484806449157007 0.007646925988921175 0.032553249366726274 7.846984932582868e-08 7.105297181302125 -1.080806102423009 down SLVEASSSGVSVLSLCEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLVEASSSGVSVLSLCEK 18 0 Q9UQ80;F8VR77;F8W0A3;H0YIN7 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 26492800.0 10097000.0 7917500.0 8478300.0 False True 9776476.261818375 11078999.039217047 6257578.886451975 1.0 1.1332302910083893 0.6400648576103736 23.220883137196363 -6.834779571933716 1.306516316249296 1.070987638481408 0.6254599834066169 0.9150809738440789 0.060701654674347044 0.17498787947048794 0.5824845771618138 0.036460503356049945 0.08391207508916641 1.4629194972538816e-07 6.834779571933716 -0.4455276550747912 SLVEASSSGVSVLSLCEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLVEASSSGVSVLSLCEK 18 0 Q9UQ80;F8VR77;F8W0A3;H0YIN7 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 36520900.0 7416900.0 29104000.0 0.0 False True 11251979.54802123 23910163.809410125 0.0 1.0 2.124973984121306 0.0 23.423675499687846 -6.767268048896291 1.6136230231621178 1.650918392721544 7.264787144373074e-10 0.7023809433673796 0.473542078341963 0.2749016494917174 1.4168755674521372 0.23248910453161903 0.5484747453168421 1.7089602100578073e-07 6.767268048896291 -1.6509183919950654 SLVEASSSGVSVLSLCEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLVEASSSGVSVLSLCEK 18 0 Q9UQ80;F8VR77;F8W0A3;H0YIN7 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 22296200.0 4579300.0 2420900.0 15296000.0 False True 6272390.960929363 2313936.63315426 11683399.831008524 1.0 0.36890822775042875 1.862670854508952 22.580584055406003 -6.79190336958894 1.488559116154432 0.6481625540987229 1.879441001901764 0.8075031771737591 0.2686275134122679 0.23251141208181486 1.0177181744968298 0.14202513324226212 0.33208363120134654 1.6147177911554532e-07 6.79190336958894 1.231278447803041 SLVEASSSGVSVLSLCEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLVEASSSGVSVLSLCEK 18 0 Q9UQ80;F8VR77;F8W0A3;H0YIN7 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 20169300.0 10097000.0 2972600.0 7099700.0 False True 8396102.872942692 2956586.013785096 8584214.444696143 1.0 0.3521378976087822 1.0224046292190703 23.00128841263064 -10.944975405780257 12.7388252414202 1.062261431322107 0.6872712634139347 0.22495911798913504 0.273635247334701 0.1340347297083163 0.0005789540956068467 0.07339263513152429 0.08831539632188704 1.135075093476889e-11 10.944975405780257 -0.3749901679081723 SLVEASSSGVSVLSLCEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLVEASSSGVSVLSLCEK 18 0 Q9UQ80;F8VR77;F8W0A3;H0YIN7 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 29158200.0 7416900.0 15207000.0 6534300.0 False True 9601323.25895633 14360717.081972672 5345124.447579853 1.0 1.495701862613226 0.556707060414178 23.194801821780295 -6.763277424436386 1.6002433049843983 1.286752135066179 0.5527187911851656 0.7041918206460118 0.20860178478356367 0.2774292407501774 1.400905673203167 0.10282010839357172 0.24628911154063485 1.7247357902293762e-07 6.763277424436386 -0.7340333438810134 SLVFSILLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLVFSILLAR 10 0 A0A0A0MSQ9;Q86VX9-2;Q86VX9-4;Q86VX9-5;Q86VX9;Q86VX9-3 A0A0A0MSQ9 MON1A Vacuolar fusion protein MON1 homolog A 0 11813800.0 2315100.0 5085900.0 4412800.0 False True 3512175.9564810055 4178281.4086819263 3540608.145801055 1.0 1.189656059506859 1.0080953203006766 21.74393369357774 -10.899701019054714 2.762117458442607 0.947773606038569 1.0988756898299814 0.283377003475215 0.07412186236515046 175449768.11183357 76585574.57387277 59212317.171958946 0.027125826970492765 1.2597923910343335e-11 10.899701019054714 0.15110208379141243 SLVFSILLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLVFSILLAR 10 0 A0A0A0MSQ9;Q86VX9-2;Q86VX9-4;Q86VX9-5;Q86VX9;Q86VX9-3 A0A0A0MSQ9 MON1A Vacuolar fusion protein MON1 homolog A 0 4572300.0 2315100.0 2257200.0 0.0 False True 2996942.587443516 2131584.835761732 0.0 1.0 0.7112531433510173 0.0 21.51506001567019 -7.406469789419586 0.7578959609142867 0.9905309731182268 6.811911625204391e-18 0.9874257281083892 0.04712127851652105 0.11362359381045649 0.13917472859967484 0.04085030528049839 0.07324068602755456 3.922204291906865e-08 7.406469789419586 -0.9905309731182268 down SLVHLHFPTWPELGLPDSPSNLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLVHLHFPTWPELGLPDSPSNLLR 24 0 Q9H3S7 Q9H3S7 PTPN23 Tyrosine-protein phosphatase non-receptor type 23 0 41157000.0 14313000.0 11797000.0 15047000.0 False True 21713867.420462426 9691733.17961829 12072953.854665618 1.0 0.44633841553647524 0.5560020065006231 24.372113369041344 -9.963288741718022 6.257219559566998 1.0000001625632673 0.5011702110187267 0.9650201598010475 0.044769973537347414 1.014622488244493e-07 1.6929935924641682e-08 0.0433483540445377 0.014449446826675576 1.0882063561898095e-10 9.963288741718022 -0.4988299515445406 SLVLDTK(ub)DLTIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLVLDTKDLTIEK 13 1 P09960;P09960-2;B4DEH5 P09960 LTA4H Leukotriene A-4 hydrolase 1 6671600.0 1926600.0 1726900.0 3018100.0 True False 1865441.1375675236 2416460.175664531 2227569.0689407885 1.0 1.2953826990303854 1.1941245553560957 20.831085407163556 -10.116102672079187 4.432367521839978 0.9999726368720511 1.2447536271483064 0.8862342689118461 0.04133846411207095 28821020.394716326 0.523738535595707 8700.167807125115 0.014151255794894412 7.654156326924736e-11 10.116102672079187 0.24478099027625533 SLVLHFLQQYYAIYDSGDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLVLHFLQQYYAIYDSGDR 19 0 E9PIN3;Q9UBU9 E9PIN3 NXF1 Nuclear RNA export factor 1 0 12626800.0 6335600.0 3598200.0 2693000.0 False True 8201559.093346775 3397957.006927995 2202901.6325134323 1.0 0.41430622742015816 0.2685954715976452 22.967466757400466 -13.999999999999998 0.19537303086231578 4.2001580049682135 0.16953006604796755 0.999487340653491 0.007156923278870337 12.443198557647982 0.14016833174935572 15.18852545499829 0.09608702765246914 1.0000000000000041e-14 13.999999999999998 -4.0306279389202455 SLVLQRPQTWADCVTWACHHWHTQYSNNIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLVLQRPQTWADCVTWACHHWHTQYSNNIR 30 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 156126000.0 25065000.0 40217000.0 90844000.0 False True 38025437.49695317 33039962.13314482 72888643.58166029 1.0 0.8688910452586426 1.9168390524764 25.18046151100559 -6.875543513848051 1.1043985973518782 0.9226824544511125 1.985027676709003 0.9699072905336724 0.08087074075017071 0.13164857056439547 0.29679133511326494 0.05661737348016047 0.13548817595685808 1.3318535914390416e-07 6.875543513848051 1.0623452222578904 SLVLQRPQTWADCVTWACHHWHTQYSNNIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLVLQRPQTWADCVTWACHHWHTQYSNNIR 30 1 P22314-2;P22314;Q5JRR6 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 141173000.0 25065000.0 62024000.0 54084000.0 False True 32447136.605015602 58572309.87652219 44241266.94870274 1.0 1.8051611330001989 1.3634875547651262 24.95158783309804 -10.12200805320469 4.240603293582479 0.9998916863915527 1.5843243439193395 0.7000324301989524 0.18031248350138837 23207676.655608043 13899852.129501145 21938.83932366579 0.061725759132194476 7.5507822597731e-11 10.12200805320469 0.5844326575277868 SLVSGSDK(ub)ENQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLVSGSDKENQK 12 1 O75665;O75665-3;O75665-2 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 10772470.0 2075880.0 2941690.0 5754900.0 True False 2721498.782850519 2502801.3186178114 5159438.152898824 1.0 0.9196408002785722 1.8958076282859067 21.375969960163623 -6.886935668059561 1.0403621504182758 0.9436317141147386 1.9748877271420942 0.978862512239918 0.06432614131689722 0.12166369463526543 0.23666462604073643 0.04729156791718372 0.11666782371679249 1.297371436079534e-07 6.886935668059561 1.0312560130273556 SLVSGSDK(ub)ENQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLVSGSDKENQK 12 1 O75665;O75665-3;O75665-2 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 10940370.0 2988870.0 2464300.0 5487200.0 True False 2893989.9578747246 3448307.8411547276 4049937.7075285474 1.0 1.1915410527848136 1.3994304632980559 21.464628485060615 -6.970077724067136 0.2563231814009447 0.9389514340385637 1.6581584574575656 0.9999829813709045 0.0006728729665666097 0.07627750149458723 0.008939874982503662 0.004445007985871695 0.019724868040281292 1.0713275565741477e-07 6.970077724067136 0.7192070234190019 SLVSGSDK(ub)ENQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLVSGSDKENQK 12 1 O75665;O75665-3;O75665-2 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 50512600.0 1348300.0 2493300.0 46671000.0 True False 2045469.6739334515 2048351.134758186 37446456.39337406 1.0 1.0014087037620036 18.307021057596167 20.964000717359156 -6.906908784522058 0.9165078097968965 0.4104053565613299 20.401834067866062 0.9897023381811716 0.8278805963790588 0.10649836410413209 0.15010999770780004 0.6676037301089676 1.8057546529776412 1.2390568000370037e-07 6.906908784522058 19.99142871130473 up SLVSGSDK(ub)ENQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLVSGSDKENQK 12 1 O75665;O75665-3;O75665-2 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 11686400.0 2075880.0 2473520.0 7137000.0 True False 2843388.9345476525 2364231.707563193 5451387.591128903 1.0 0.8314837547679044 1.9172148856927835 21.439180021686514 -6.867265955516585 1.1485295129544537 0.9061093552184619 1.9775638554453896 0.9618737850714185 0.09315535565686292 0.1394995787931913 0.34564881982939816 0.0630478711358885 0.1485925631611394 1.3574818901672022e-07 6.867265955516585 1.0714545002269276 SLVSGSDK(ub)ENQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLVSGSDKENQK 12 1 O75665;O75665-3;O75665-2 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 13097070.0 2988870.0 4460200.0 5648000.0 True False 2485377.834391624 4436172.0173196215 6828970.686598559 1.0 1.7849084979892067 2.747658964404568 21.24503376049489 -6.968385311668834 0.2942067133111519 0.8211035347025418 3.741384832660987 0.9999669068234833 0.0041114792377434295 0.07683018888097118 0.010895545419417816 0.01644962064673648 0.08689031956980545 1.0755105833434927e-07 6.968385311668834 2.920281297958445 SLVSGSDK(ub)ENQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLVSGSDKENQK 12 1 O75665;O75665-3;O75665-2 O75665 OFD1 Oral-facial-digital syndrome 1 protein 1 30807400.0 1348300.0 4863800.0 24595300.0 True False 1745400.928966389 4593125.254376188 20119207.76908935 1.0 2.6315588459645176 11.526983534381275 20.735127039451605 -6.937894268765096 0.6788718573754327 0.8955819254048767 13.78414359176003 0.997874873033563 0.21325945121572246 0.08874053645630474 0.059083851532037095 0.20441859347700939 0.7729829546161338 1.1537341061603041e-07 6.937894268765096 12.888561666355153 SLVSK(ub)GTLVQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLVSKGTLVQTK 12 1 P10412;Q02539;P16401;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1B;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1.5;Histone H1.3;Histone H1.2 1 13930500.0 3765500.0 5668500.0 4496500.0 True False 4936606.965153875 4822781.895639937 4031245.313473662 1.0 0.9769426510318936 0.8166024441340161 22.235088356798318 -6.932798625351409 0.723448232097484 1.0022031395835937 0.7812093889217593 0.9970602970817302 0.004422358045987743 0.09121048493050775 0.07074992642732719 0.004098269356673846 0.014291323238529772 1.1673507714379509e-07 6.932798625351409 -0.22099375066183446 SLVSK(ub)GTLVQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLVSKGTLVQTK 12 1 P10412;Q02539;P16401;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1B;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1.5;Histone H1.3;Histone H1.2 1 19993100.0 5929700.0 8158700.0 5904700.0 True False 5741464.919253675 11416511.45705845 4358081.932797011 1.0 1.988431805752889 0.7590540034795704 22.452987452932707 -6.692658966660367 1.8567635224502106 1.6181200503218784 0.763135246577861 0.38301572196941847 0.417812086345921 0.4109650596719965 2.7489562927884355 0.1798692359524446 0.46686340519071057 2.0292755995034682e-07 6.692658966660367 -0.8549848037440174 SLVSK(ub)GTLVQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLVSKGTLVQTK 12 1 P10412;Q02539;P16401;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1B;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1.5;Histone H1.3;Histone H1.2 1 10137610.0 3765500.0 3931400.0 2440710.0 True False 5157707.108811291 3757697.7485987297 1864264.566000312 1.0 0.7285597396911465 0.3614521970073585 22.29829841832121 -6.9669209010255315 0.3233925649115928 1.0483152151425534 0.02979644374442967 0.9999474411425829 0.0018969565699551746 0.07731503027729156 0.012592958459267604 0.005490186352206959 0.032196336140601016 1.0791432509797126e-07 6.9669209010255315 -1.0185187713981239 down SLVSK(ub)GTLVQTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLVSKGTLVQTK 12 1 P10412;Q02539;P16401;P16402;P16403 P10412;P16402;P16403 HIST1H1E;HIST1H1A;HIST1H1B;HIST1H1D;HIST1H1C Histone H1.4;Histone H1.1;Histone H1.5;Histone H1.3;Histone H1.2 1 23518700.0 5929700.0 16283400.0 1305600.0 True False 4930808.280250394 16195678.09219815 1578594.9235876573 1.0 3.2845888892227846 0.32014932113878375 22.233392728366983 -6.700863397516746 1.8276416165578058 2.4174242554649124 0.3287803865937246 0.42173696242204306 0.9642006122512149 0.39373339273536373 2.557456180922151 0.42077140837916926 1.0810210825860016 1.991299581556893e-07 6.700863397516746 -2.0886438688711877 SLVSVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLVSVTK 7 0 P08238;Q58FF7;Q58FF8 P08238;Q58FF7;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 0 58313500.0 9861500.0 25031000.0 23421000.0 False True 12928521.998901859 21296472.37007379 20997619.59009599 1.0 1.6472472547041883 1.6241314816867323 23.624054018498633 -10.08528372470238 4.642095398186068 0.9999639387613095 1.6356893682113145 0.9990092641160863 0.009436974871340681 6559378.713009656 0.12513989723494076 2528.367126755869 0.0032305274991533423 8.217056540305662e-11 10.08528372470238 0.635725429450005 SLVSVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLVSVTK 7 0 P08238;Q58FF7;Q58FF8 P08238;Q58FF7;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 0 65761000.0 18818000.0 14385000.0 32558000.0 False True 18220632.890452422 20129005.51678399 24030083.08093639 1.0 1.1047369011716137 1.3188390999045982 24.119069735978247 -6.959615153744014 0.440824716123488 0.9924101108967306 1.4395248552038449 0.9997556551120221 0.002074194127606782 0.0798388939671854 0.021641503689195794 0.0028257271553645 0.017736958229759476 1.0974502613347693e-07 6.959615153744014 0.4471147443071143 SLVSVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLVSVTK 7 0 P08238;Q58FF7;Q58FF8 P08238;Q58FF7;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 0 197967000.0 26742000.0 147340000.0 23885000.0 False True 40569569.10207554 121046025.82732564 19164119.2808326 1.0 2.983665552936152 0.4723767026614084 25.273894643669696 -6.696107892953818 1.8446951936781453 2.2363776082332234 0.4803319390216729 0.39931695995440863 0.8379285132333667 0.40358536589903127 2.6671837078622973 0.3627608391722946 0.9374523745783904 2.0132240370328273e-07 6.696107892953818 -1.7560456692115505 SLVSVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLVSVTK 7 0 P08238;Q58FF7;Q58FF8 P08238;Q58FF7;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 0 72113500.0 9861500.0 27608000.0 34644000.0 False True 13507563.047017014 26388187.272552714 26461800.715576563 1.0 1.953586089563375 1.9590358840797963 23.687264080021524 -11.02196063688331 0.8530388036734659 1.3023002513770901e-05 1.9577724919285904 0.9999953839561838 0.0009685575325862239 3.3574501367888283 0.46761111698357044 6.571637290786719 0.0007625915418260873 9.50690957457089e-12 11.02196063688331 1.9577594689260767 SLVSVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLVSVTK 7 0 P08238;Q58FF7;Q58FF8 P08238;Q58FF7;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 0 37505300.0 18818000.0 11901000.0 6786300.0 False True 15648000.778749678 11836886.950836442 8205283.953694033 1.0 0.7564472368196191 0.5243662797382389 23.899475011412523 -6.97171153066019 0.21339323829668505 1.116369183878378 0.1579406939978271 0.9999928302229967 0.0005199542909885709 0.07575121795595514 0.007007867089559208 0.006766133008700655 0.023863950630776672 1.0673048165945479e-07 6.97171153066019 -0.958428489880551 SLVSVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLVSVTK 7 0 P08238;Q58FF7;Q58FF8 P08238;Q58FF7;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 0 74232000.0 26742000.0 22944000.0 24546000.0 False True 34618046.163627714 21667146.23060304 20078879.863228653 1.0 0.6258916557043636 0.5800119327452111 25.045020965762145 -13.99999999991947 0.2959861737241995 4.334965658870226 0.568246866860286 0.9996408616761042 0.0035647660051998415 16.331752585880164 0.1726719729350075 33.27967132643501 0.016872271576469446 1.0000000001854257e-14 13.99999999991947 -3.7667187920099403 SLVSVTK(ub)EGLELPEDEEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLVSVTKEGLELPEDEEEK 19 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 38514900.0 9340900.0 16219000.0 12955000.0 True False 12246010.35740428 13799188.42116684 11614540.873134937 1.0 1.1268313531046021 0.9484346766138786 23.545808472615985 -6.715776404331972 1.774614609473501 1.077508309790118 0.9487780677284409 0.49250151113910046 0.0534004546322537 0.3635722058570374 2.2353080019224274 0.02391533275541719 0.06033442477351743 1.92408208386e-07 6.715776404331972 -0.12873024206167705 SLVSVTK(ub)EGLELPEDEEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLVSVTKEGLELPEDEEEK 19 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 54854000.0 18685000.0 17266000.0 18903000.0 True False 18091854.902651917 24160403.84100052 13951737.222155582 1.0 1.3354298921256034 0.7711612378734326 24.1088369948721 -6.74561965270779 1.6656871500841215 1.198259268378224 0.7703766281867851 0.6301279893996221 0.14093007024224663 0.3077154128279086 1.6782720930318584 0.0668723002286805 0.16312499298988622 1.7963061107230818e-07 6.74561965270779 -0.42788264019143896 SLVSVTK(ub)EGLELPEDEEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLVSVTKEGLELPEDEEEK 19 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 48297000.0 18685000.0 19353000.0 10259000.0 True False 15537405.385850674 19248741.54773025 12404109.467743391 1.0 1.2388646025326306 0.7983385359205047 23.889242270306376 -6.7594545597043805 1.6146082033514098 1.1388395593280671 0.796776580153489 0.6887179475682315 0.10045895368829892 0.28382768183565976 1.4582169333106922 0.04909495542669655 0.11804255587278202 1.7399847433744312e-07 6.7594545597043805 -0.3420629791745782 SLVSVTK(ub)EGLELPEDEEEKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLVSVTKEGLELPEDEEEKK 20 2 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 20763300.0 3604600.0 11171700.0 5987000.0 True False 4725665.506996052 9504925.906945536 5367522.671359236 1.0 2.0113412370964654 1.135823655612729 22.172086085119993 -10.299933035226463 4.03681387034987 0.9991469548554517 1.5735824463818628 0.36397677399757156 0.3574285560381398 48280440.321996234 61597237.50568935 299209.36746573535 0.12235730440608171 5.0126451869217665e-11 10.299933035226463 0.5744354915264112 SLVSVTK(ub)EGLELPEDEEEKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLVSVTKEGLELPEDEEEKK 20 2 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 42428000.0 15500900.0 11765200.0 15161900.0 True False 15008832.414263668 16463105.71470748 11190543.542749852 1.0 1.0968944992057972 0.7455972079556902 23.839308413610503 -6.8331535369613885 1.3137929453976924 1.0516700992433705 0.7355220735072607 0.9120383539477962 0.04393695722699826 0.17694439374119225 0.5961934444624549 0.02624941011593709 0.06040732479376074 1.4684070571046964e-07 6.8331535369613885 -0.3161480257361098 SLVSVTK(ub)EGLELPEDEEEKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLVSVTKEGLELPEDEEEKK 20 2 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 98494100.0 19830100.0 28936000.0 49728000.0 True False 30083711.47449955 23772144.7220001 39899239.003443345 1.0 0.7901998642072655 1.3262738222065427 24.842479229749134 -6.800583868027543 1.4538033957320071 0.884329552575538 1.3337574957775316 0.8337848133460264 0.08992382771346978 0.21992934183257049 0.9176719246617855 0.0486619131479132 0.11311570050020137 1.582763884482374e-07 6.800583868027543 0.44942794320199353 SLVSVTK(ub)EGLELPEDEEEKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLVSVTKEGLELPEDEEEKK 20 2 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 17657300.0 3604600.0 10056800.0 3995900.0 True False 4937318.030652279 9612457.322609691 3052150.7181437565 1.0 1.9468985515886992 0.6181798902147145 22.235296146642884 -6.715356827485606 1.7759328809599846 1.5789337754319597 0.620766157423356 0.4904771880021894 0.39870449163072524 0.3644621133047137 2.243829700090424 0.1784346824398206 0.4504178162011519 1.925941859710654e-07 6.715356827485606 -0.9581676180086037 SLVSVTK(ub)EGLELPEDEEEKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLVSVTKEGLELPEDEEEKK 20 2 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 34271600.0 15500900.0 14306100.0 4464600.0 True False 12889685.156303575 14229030.199761499 5398127.218021951 1.0 1.10390828225955 0.41879434234140694 23.61971368904478 -6.868248926861154 1.143380315713886 1.0581832351333254 0.3799941480273523 0.9629008180149079 0.058067313960531455 0.13854160888250383 0.33961103513719926 0.039455520046875754 0.0931348331765843 1.3544128738481076e-07 6.868248926861154 -0.678189087105973 down SLVSVTK(ub)EGLELPEDEEEKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLVSVTKEGLELPEDEEEKK 20 2 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 97481100.0 19830100.0 21955000.0 55696000.0 True False 25670455.359709557 20733184.95000392 45559899.489219554 1.0 0.8076672057226219 1.7747990384590915 24.613605551841584 -6.855017950754033 1.2106008656301126 0.8967367162629636 1.8173773366204842 0.9472967780373892 0.09596509318608452 0.15202379609796235 0.42622292052769234 0.0619389318653005 0.14387128768130708 1.3963106459616528e-07 6.855017950754033 0.9206406203575206 SLVSVTK(ub)EGLELPEDEEEKKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLVSVTKEGLELPEDEEEKKK 21 3 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 40815700.0 15450000.0 15915000.0 9450700.0 True False 20255099.618012838 13540544.036184113 8472832.221515749 1.0 0.6685004908167681 0.41830612444783377 24.27178184467206 -7.662222235989916 0.17844112954198457 1.2534884660993841 1.1072109260406786e-13 0.9999506459874342 0.0016737362858230296 0.1337158526393878 0.020893740415917142 0.04873969709781027 0.08110566152420322 2.17659568571025e-08 7.662222235989916 -1.2534884660992733 down SLVSVTK(ub)EGLELPEDEEEKKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLVSVTKEGLELPEDEEEKKK 21 3 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 69598000.0 15055000.0 21854000.0 32689000.0 True False 14577087.265690345 30580416.16710443 24126770.251020648 1.0 2.09784133206643 1.6551159920546752 23.79719913921603 -10.16468619020117 5.463727818114233 0.999976077347371 1.8764786620607035 0.8393780366821103 0.18074186320536412 5.2671379042555804e-05 8.05267080730014e-06 0.17500731783585757 0.058334185512995726 6.844060024777492e-11 10.16468619020117 0.8765025847133324 SLVSVTK(ub)EGLELPEDEEEKKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLVSVTKEGLELPEDEEEKKK 21 3 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 238168900.0 39580500.0 61615400.0 136973000.0 True False 60046512.222148634 50619650.46668247 109900226.51260132 1.0 0.8430073387011978 1.8302516240412667 25.83957711420669 -6.866206405421709 1.1540473072707444 0.9129618748656549 1.8840321714441763 0.9607441884977411 0.08582150770315933 0.1405401857660206 0.35222512551631524 0.05783918416422802 0.13609760213885558 1.3607977877690346e-07 6.866206405421709 0.9710702965785214 SLVSVTK(ub)EGLELPEDEEEKKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLVSVTKEGLELPEDEEEKKK 21 3 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 41643000.0 15450000.0 11848000.0 14345000.0 True False 21162282.520550903 11324516.183903392 10957006.444548706 1.0 0.5351273508850495 0.5177610890464319 24.33499190619495 SLVSVTK(ub)EGLELPEDEEEKKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLVSVTKEGLELPEDEEEKKK 21 3 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 58377300.0 15055000.0 31992300.0 11330000.0 True False 12518899.549584236 31819951.12992568 13699050.615998881 1.0 2.5417530513680373 1.0942695531456548 23.577604414650306 -6.631312516222088 2.075960638113695 2.0147674696925733 1.1001506624918957 0.12217206837037631 0.6611129272629106 0.5555689531115156 4.5645641345252415 0.26033060452570617 0.7321978632465317 2.337154828022074e-07 6.631312516222088 -0.9146168072006775 SLVSVTK(ub)EGLELPEDEEEKKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLVSVTKEGLELPEDEEEKKK 21 3 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 270619200.0 39580500.0 73577700.0 157461000.0 True False 51237737.49829725 69483036.31500354 128804713.68629695 1.0 1.3560910318749462 2.5138641941513797 25.61070343629914 -6.949629452925849 0.5628991082171994 0.9850813882173597 2.940481519756252 0.9991718672041195 0.018598001736564403 0.08363492553724833 0.03658111002888337 0.019866903783969696 0.09630407550205007 1.1229761871077644e-07 6.949629452925849 1.9554001315388922 up SLYDEVAAQGEVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLYDEVAAQGEVVR 14 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 14362500.0 4225500.0 1845600.0 8291400.0 False True 4091363.8154217596 2582557.704676852 6119633.60333179 1.0 0.6312217199903618 1.4957441771041684 21.964150400700078 -6.7907999127799235 1.4930344977835293 0.7940959904937331 1.5051520650127 0.8038952502497851 0.15685570200642693 0.23418560196580868 1.0312641212598679 0.08268672206433235 0.19348610432394125 1.6188256877535047e-07 6.7907999127799235 0.7110560745189668 SLYPSSEIQLNNK(ub)VAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLYPSSEIQLNNKVAR 16 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 14011000.0 4348000.0 4688600.0 4974400.0 True False 5700270.106091893 3989079.1560196592 4459696.8058141675 1.0 0.6998052867278202 0.7823658743904219 22.442598852020268 -9.985274589596298 6.652403834248295 1.000000046003728 0.7410855805591194 0.9291438867932237 0.033705218772955646 2.2987145493076486e-08 3.5088571595698747e-09 0.03263494358254666 0.010878312582326926 1.0344878884348947e-10 9.985274589596298 -0.2589144654446085 SLYPSSEIQLNNK(ub)VAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLYPSSEIQLNNKVAR 16 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 27512500.0 7174100.0 11032000.0 9306400.0 True False 6946362.122403794 15437135.131119998 6868774.653984483 1.0 2.2223337711305446 0.9888304889592394 22.727826191472108 -6.648298947255489 2.0149049465606215 1.7942621598261663 0.9940451316865246 0.18703790391317066 0.5219295895405124 0.5127315748899961 3.9881115493243535 0.21023532639906817 0.577954541472735 2.247506998447624e-07 6.648298947255489 -0.8002170281396417 SLYPSSEIQLNNK(ub)VAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLYPSSEIQLNNKVAR 16 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 68382400.0 8655400.0 22393000.0 37334000.0 True False 13130874.59449944 18396794.19269245 29954918.535926506 1.0 1.4010334239578313 2.281258443247543 23.646459675729876 -6.958186740723245 0.4602835147137961 0.9744155086441103 2.7433763905444306 0.999696902676982 0.009316391730342384 0.08035542564445826 0.023574194018271013 0.011960215260557683 0.07271312030567441 1.101065764429356e-07 6.958186740723245 1.7689608819003202 up SLYPSSEIQLNNK(ub)VAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLYPSSEIQLNNKVAR 16 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 25877600.0 7174100.0 10784000.0 7919500.0 True False 5965582.016517587 10725904.451543598 9575430.834369209 1.0 1.797964460440836 1.6051125955282521 22.508231466906384 -10.047275828575625 4.563704410489699 0.9999698641358007 1.7015385279252144 0.9463630967698218 0.0787314442971484 72690400.83145106 52946040.09351823 27500.825452863293 0.028812759835872982 8.968590015940406e-11 10.047275828575625 0.7015686637894137 SLYPSSEIQLNNK(ub)VAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLYPSSEIQLNNKVAR 16 1 O75886-2;O75886 O75886-2 STAM2 Signal transducing adapter molecule 2 1 56563400.0 8655400.0 20335000.0 27573000.0 True False 11204585.923441136 19203339.374098364 22554996.922871497 1.0 1.713882110888455 2.0130147670771255 23.417585997822325 -10.415395832743478 0.1893755117246098 4.454487635785062e-16 2.2939915414772862 0.9994552450558964 0.009918521884512456 2.119812423757969 0.09569277970055669 1.2059715719557351 0.19750997500099923 3.8424140995535474e-11 10.415395832743478 2.293991541477286 SLYQSAGVAPESFEYIEAHGTGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLYQSAGVAPESFEYIEAHGTGTK 24 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 32193800.0 4385800.0 13596000.0 14212000.0 False True 5749826.272147616 11567529.79679292 12741478.571130367 1.0 2.0118050962385574 2.215976269204965 22.455086935799017 -10.683050783950774 0.3209296307025413 1.1470547650076408e-09 2.2668726841803863 0.9991708821961295 0.015309050849188169 2.318465016476642 0.15758638210619538 1.88229496985361 0.06735936839813049 2.0746709029393223e-11 10.683050783950774 2.2668726830333314 SLYQSAGVAPESFEYIEAHGTGTK(ub)VGDPQELNGITR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLYQSAGVAPESFEYIEAHGTGTKVGDPQELNGITR 36 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 39723600.0 5322900.0 9480700.0 24920000.0 True False 5153927.45310815 13266392.951197358 18392704.416024823 1.0 2.574035640179 3.5686773986181817 22.297240799230725 -8.421678155007962 0.21499655651379687 1.7394807156171047e-14 4.615626427842326 0.9996311284564283 0.020310624648512333 0.13139410870752916 0.05372554352552724 0.48885439265267533 0.4382434701828222 3.787231431822233e-09 8.421678155007962 4.615626427842308 SLYQSAGVAPESFEYIEAHGTGTK(ub)VGDPQELNGITR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLYQSAGVAPESFEYIEAHGTGTKVGDPQELNGITR 36 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 225874000.0 28083000.0 32453000.0 165338000.0 True False 42603964.142307505 26661508.59355367 132658871.82978016 1.0 0.6257987755434636 3.1137682725172606 25.3444843383803 -6.868589620206886 1.141465401677158 0.7900473808477773 3.2556632676141897 0.9632586067685969 0.20995630573593632 0.13821782170187882 0.33745698500627147 0.1428619808955004 0.3374441119920052 1.3533507868861998e-07 6.868589620206886 2.4656158867664124 up SLYQSAGVAPESFEYIEAHGTGTK(ub)VGDPQELNGITR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLYQSAGVAPESFEYIEAHGTGTKVGDPQELNGITR 36 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 46225900.0 5322900.0 10654000.0 30249000.0 True False 4426227.194452472 10596604.787346587 36573926.04442631 1.0 2.3940489997051304 8.263002425692369 22.077646074665 -6.9437004838578344 0.6241876090417631 0.9359110938750699 10.034308835467609 0.9986095340069677 0.11735275107440525 0.08611825430951976 0.04722121043414257 0.11773570882644563 0.49748719303692523 1.1384121340633318e-07 6.9437004838578344 9.098397741592539 SLYQSAGVAPESFEYIEAHGTGTK(ub)VGDPQELNGITR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLYQSAGVAPESFEYIEAHGTGTKVGDPQELNGITR 36 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 201313000.0 28083000.0 23543000.0 149687000.0 True False 36353997.09868959 22232811.354039717 122445501.91832106 1.0 0.6115644256031785 3.3681441296790635 25.11561066047275 -6.871220745437803 1.1276946326791122 0.7786326272974555 3.5333190156271916 0.9658825673227363 0.22502620313715593 0.13568578608454912 0.3217628362356263 0.15475252852100332 0.3671586173901471 1.3451764470426583e-07 6.871220745437803 2.754686388329736 up SLYTQLCFYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLYTQLCFYR 10 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 22481000.0 5894300.0 4768700.0 11818000.0 False True 8942084.031050919 3917688.2269768408 9482167.119986594 1.0 0.4381180285683822 1.0603978990870881 23.092179672642754 -6.6688384089059936 1.9412449384935198 0.6410033620355392 1.0578846428996844 0.2740337897052042 0.23873778003066776 0.4637788614246214 3.3682439753985634 0.09904091606917292 0.2650376796157628 2.1436880703004552e-07 6.6688384089059936 0.4168812808641452 SLYTQLCFYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLYTQLCFYR 10 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 17796500.0 5894300.0 4522800.0 7379400.0 False True 7630287.544023286 4271102.204139275 6036424.919038117 1.0 0.559756389192014 0.7911136879456631 22.863305994735203 -10.036992282069464 4.9977814538342304 1.0000048776423975 0.6754350385673262 0.7240672208921252 0.09445122171128374 130672124.98225403 11.314842198492588 7508.846663529622 0.03233316544566358 9.183489164933018e-11 10.036992282069464 -0.3245698390750713 SLYVAEYHSEPVEDEKP ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLYVAEYHSEPVEDEKP 17 1 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 17019700.0 2406900.0 6010400.0 8602400.0 False True 3155469.2084527556 5113671.748355705 7712306.168047557 1.0 1.6205741240185099 2.4441075664399174 21.589423114746623 -6.967212948135646 0.3177877503095943 0.8842490428179856 3.2069091313367317 0.9999517647754065 0.004108002308226371 0.07721781554370727 0.012252868610977123 0.012597007547803315 0.07258324365630806 1.078417810667365e-07 6.967212948135646 2.322660088518746 SLYVAEYHSEPVEDEKP ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLYVAEYHSEPVEDEKP 17 1 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 14855100.0 2519000.0 2292100.0 10044000.0 False True 2439035.7238308857 3207347.483143595 7413175.086458788 1.0 1.3150063575559099 3.039387662110681 21.21787945833823 -6.937806031855126 0.679665406956874 0.9797135715953185 3.4758492938383174 0.9978622181193951 0.04144615995618892 0.08878190044942452 0.05927493176711539 0.03970324165428387 0.14990509121060483 1.1539685375866746e-07 6.937806031855126 2.496135722242999 up SLYVAEYHSEPVEDEKP ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLYVAEYHSEPVEDEKP 17 1 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 17967600.0 2406900.0 5423700.0 10137000.0 False True 3296795.974026792 5184063.000222548 7742849.37806834 1.0 1.5724549050242254 2.3485982872670834 21.652633176269514 -6.96688220305804 0.3241271791099221 0.8987260565448331 3.047514250168198 0.9999468522056763 0.0040289707402891015 0.07732792818676332 0.012638054979337232 0.011574470126446182 0.06802719279154618 1.0792394127151013e-07 6.96688220305804 2.148788193623365 SLYVAEYHSEPVEDEKP ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLYVAEYHSEPVEDEKP 17 1 P26196 P26196 DDX6 Probable ATP-dependent RNA helicase DDX6 0 7232500.0 2519000.0 2992200.0 1721300.0 False True 2094660.110621235 2976080.4246948054 2081215.8716080245 1.0 1.420793955832843 0.9935816608408018 20.998284733772508 -10.54847900526918 12.245584224695333 0.9999993868405757 1.2071878083368226 0.23873475398355426 0.1744086890956444 2.9172761521754666e-06 1.0757555942200137e-07 0.1688709865251392 0.05629016235844151 2.8282708324474996e-11 10.54847900526918 0.20718842149624694 SLYVPVMITWNPHWYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLYVPVMITWNPHWYR 16 0 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 0 16906500.0 9796600.0 3540100.0 3569800.0 False True 9485612.295387715 4953680.39137762 2634762.28829556 1.0 0.5222309574877204 0.2777640711266143 23.17730947179683 -9.61573120647394 0.18000451737147796 1.5627596611221144 1.901892554547931e-25 0.9996081010630906 0.005937652726806166 1.057645129943147 0.07379420234877691 0.4678868597271512 0.16028433587481788 2.4225279337496513e-10 9.61573120647394 -1.5627596611221144 SLYVPVMITWNPHWYR ddPTM_RPMI8226_Bortezomib_8h_R1 2 SLYVPVMITWNPHWYR 16 0 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 0 233179100.0 102834900.0 62823200.0 67521000.0 False True 156008061.538218 51611909.12009807 54175444.75449436 1.0 0.33082847521603537 0.34726054679695356 27.217045339729445 -9.769577079070233 6.407614281327264 1.0000000086317171 0.3390445110789884 0.9995366592243966 0.006708365132926567 8.32196685151066e-10 1.510518673690324e-10 0.00649534670626717 0.0021651155364930223 1.6998982270297716e-10 9.769577079070233 -0.6609554975527288 SLYVPVMITWNPHWYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLYVPVMITWNPHWYR 16 0 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 0 22490500.0 9796600.0 5980800.0 6713100.0 False True 8146306.962966252 5948580.243304152 8116778.172132576 1.0 0.7302180325817407 0.9963751929594703 22.957714747231105 -10.836152849890208 9.515103366729521 1.0037736043356598 0.863296612795317 0.2602124164355405 0.10865820571892436 0.00887807318608958 0.00015287746722804637 0.10738215034641099 0.03506928509818111 1.458300921113585e-11 10.836152849890208 -0.14047699154034277 SLYVPVMITWNPHWYR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SLYVPVMITWNPHWYR 16 0 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 0 203989900.0 102834900.0 61118100.0 40036900.0 False True 133121805.2289297 57716824.00787228 32750595.01328518 1.0 0.4335640123615857 0.24601976330597342 26.988171661821895 -13.99999999999975 0.15447514069761578 3.759549117084205 0.049935014261845274 0.9995519964711037 0.006783827925747007 11.97739136807986 0.12399427583130337 9.910344527732125 0.17755690568435745 1.0000000000005767e-14 13.99999999999975 -3.7096141028223597 SLYYYIQQDTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SLYYYIQQDTK 11 0 P07355;P07355-2;A6NMY6 P07355 ANXA2;ANXA2P2 Annexin A2;Putative annexin A2-like protein 0 88416000.0 23476000.0 31871000.0 33069000.0 False True 30777263.3419074 27115971.032184996 29647337.10024697 1.0 0.8810390557130184 0.9632869813957148 24.875361619770274 -10.127717601749156 4.96950460953608 1.000003600597203 0.9221630185541217 0.5442437327764191 0.033577575055007705 1.3395447065440027e-06 2.351578395388609e-07 0.03251285101324983 0.010837115749384977 7.452163903729575e-11 10.127717601749156 -0.07784058204308131 SLYYYIQQDTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLYYYIQQDTK 11 0 P07355;P07355-2;A6NMY6 P07355 ANXA2;ANXA2P2 Annexin A2;Putative annexin A2-like protein 0 108606000.0 30309000.0 16754000.0 61543000.0 False True 29346857.385307778 23443959.570955805 45423042.04957517 1.0 0.7988575833912901 1.5477991886216675 24.806702684501666 -6.835207338329003 1.3043307111765141 0.8928418238801896 1.570204964626252 0.9159154067744955 0.09177178206288544 0.17447422993050568 0.5786282536401168 0.05520834436265548 0.1270814609612388 1.4614792769966218e-07 6.835207338329003 0.6773631407460623 SLYYYIQQDTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLYYYIQQDTK 11 0 P07355;P07355-2;A6NMY6 P07355 ANXA2;ANXA2P2 Annexin A2;Putative annexin A2-like protein 0 155524000.0 39223000.0 78200000.0 38101000.0 False True 59504158.58539771 64244599.02061125 30570320.649738487 1.0 1.0796656998083634 0.5137509944933567 25.826487162226716 -6.8712583179370235 1.1274856041390573 1.0454130664928523 0.479815714193393 0.9659195807873572 0.04617452538839917 0.13565055585389343 0.3215353203431425 0.03175958518166151 0.0753569782022572 1.3450600756474413e-07 6.8712583179370235 -0.5655973522994593 SLYYYIQQDTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLYYYIQQDTK 11 0 P07355;P07355-2;A6NMY6 P07355 ANXA2;ANXA2P2 Annexin A2;Putative annexin A2-like protein 0 80831000.0 23476000.0 32682000.0 24673000.0 False True 32155711.615045495 31238001.175078534 18845745.55638551 1.0 0.9714604219942821 0.586077701591517 24.938571681293165 -6.921763045954544 0.8115569337982963 1.007975218362647 0.521342091811626 0.994656474055066 0.013798095228729391 0.09714569776248093 0.10032456929591278 0.012000777125816278 0.03657615871166758 1.1973936593014918e-07 6.921763045954544 -0.48663312655102087 SLYYYIQQDTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLYYYIQQDTK 11 0 P07355;P07355-2;A6NMY6 P07355 ANXA2;ANXA2P2 Annexin A2;Putative annexin A2-like protein 0 72642000.0 30309000.0 29333000.0 13000000.0 False True 25203276.416363236 29174977.306855366 15718239.894791301 1.0 1.157586689320818 0.6236585924434106 24.587107959935942 -6.827649377625331 1.3383108418733252 1.0843516183937432 0.6099617116910261 0.9011040534982993 0.0704399132653305 0.1837298930423502 0.6443948275122259 0.04133464630139658 0.09513998732534304 1.4871357787710383e-07 6.827649377625331 -0.4743899067027171 SLYYYIQQDTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SLYYYIQQDTK 11 0 P07355;P07355-2;A6NMY6 P07355 ANXA2;ANXA2P2 Annexin A2;Putative annexin A2-like protein 0 134647000.0 39223000.0 55274000.0 40150000.0 False True 50774946.700918674 52197953.31024907 32843111.973789178 1.0 1.0280257627391 0.6468369561714369 25.597613484319165 -6.889208047774537 1.0270851345292737 1.0208723653693557 0.6145588959459978 0.9803854888777438 0.02429424585974066 0.11978688285416941 0.22563416745269324 0.018041661222360218 0.044850602686935186 1.290600866119959e-07 6.889208047774537 -0.4063134694233579 SLYYYIQQDTK(ub)GDYQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SLYYYIQQDTKGDYQK 16 1 P07355;P07355-2;A6NMY6 P07355 ANXA2;ANXA2P2 Annexin A2;Putative annexin A2-like protein 1 17879400.0 5923100.0 6921200.0 5035100.0 True False 5735074.432641014 9684871.25358118 3716256.260237821 1.0 1.6887089029673281 0.6479874505354025 22.451380779698706 -6.7282738172785574 1.7294533747896448 1.4152696777551086 0.648800570386512 0.551184854736073 0.28956061189841403 0.3395315039806789 1.9887226298186116 0.13272151723419467 0.3299939102851326 1.8695030702366403e-07 6.7282738172785574 -0.7664691073685966 SLYYYIQQDTK(ub)GDYQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SLYYYIQQDTKGDYQK 16 1 P07355;P07355-2;A6NMY6 P07355 ANXA2;ANXA2P2 Annexin A2;Putative annexin A2-like protein 1 28298100.0 5815200.0 8707900.0 13775000.0 True False 8822083.548066314 7153907.20986676 11052365.212203026 1.0 0.810909029696823 1.2528066813225274 23.072687992621024 -6.790444128053329 1.494712962319528 0.8943781435139342 1.2575539767858712 0.8027135354568802 0.08040708837434135 0.23469040013324727 1.0358616660598963 0.042342720720856646 0.09909607702888829 1.6201524129613745e-07 6.790444128053329 0.36317583327193703 SLYYYIQQDTK(ub)GDYQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SLYYYIQQDTKGDYQK 16 1 P07355;P07355-2;A6NMY6 P07355 ANXA2;ANXA2P2 Annexin A2;Putative annexin A2-like protein 1 10893700.0 3320000.0 3377000.0 4196700.0 True False 4547493.7196264705 3227792.9737543655 3205525.89374957 1.0 0.7097960267264526 0.704899465812318 22.116640214750138 SLYYYIQQDTK(ub)GDYQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SLYYYIQQDTKGDYQK 16 1 P07355;P07355-2;A6NMY6 P07355 ANXA2;ANXA2P2 Annexin A2;Putative annexin A2-like protein 1 16773300.0 5923100.0 7802000.0 3048200.0 True False 4925320.087820816 7759969.077424247 3685564.5267156074 1.0 1.5755258417849565 0.7482893418093092 22.231786055132982 -6.7195947476727635 1.760620874428593 1.3502888352796878 0.7495940312201185 0.5106849111667686 0.24219509974503098 0.35609956448945657 2.15700103469323 0.10923219667916634 0.2743602469467109 1.9072395864772386e-07 6.7195947476727635 -0.6006948040595693 SMAQWLSTLPIHNFSATALTAGGTGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SMAQWLSTLPIHNFSATALTAGGTGAK 27 0 F5H1S9;G8JLB3;Q9Y606-2;Q9Y606 F5H1S9 PUS1 tRNA pseudouridine synthase;tRNA pseudouridine synthase A, mitochondrial 0 44699000.0 15934000.0 14206000.0 14559000.0 False True 24173042.93143636 11670828.308015378 11681407.26856361 1.0 0.48280344105283474 0.48324107567658636 24.526895756916637 -10.087079073446505 5.168045983411197 1.0000098956773114 0.48302225842015706 0.9999994619854976 0.00017866359044813718 2.037197133025611e-08 3.5983897225534454e-09 0.00017299358608166882 5.766342536831125e-05 8.18315781083335e-11 10.087079073446505 -0.5169876372571542 SMAQWLSTLPIHNFSATALTAGGTGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SMAQWLSTLPIHNFSATALTAGGTGAK 27 0 F5H1S9;G8JLB3;Q9Y606-2;Q9Y606 F5H1S9 PUS1 tRNA pseudouridine synthase;tRNA pseudouridine synthase A, mitochondrial 0 118905000.0 72921000.0 13494000.0 32490000.0 False True 60637042.4480394 13421305.143650707 39283508.78321308 1.0 0.22133838660009816 0.6478467154277121 25.853696052456655 -10.303704441447344 5.459434443493877 1.0000893267577025 0.43459255102799865 0.7008841223457383 0.17412129611253369 0.00018934371926186108 2.4149033772206554e-05 0.16861863804561744 0.056197406671982274 4.969303917413992e-11 10.303704441447344 -0.5654967757297038 SMAQWLSTLPIHNFSATALTAGGTGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SMAQWLSTLPIHNFSATALTAGGTGAK 27 0 F5H1S9;G8JLB3;Q9Y606-2;Q9Y606 F5H1S9 PUS1 tRNA pseudouridine synthase;tRNA pseudouridine synthase A, mitochondrial 0 33966800.0 15934000.0 9965700.0 8067100.0 False True 20626877.106096916 9411100.03444565 6598970.575435996 1.0 0.45625423499827356 0.3199209721129072 24.298022079009087 -13.999999999999824 0.19426841120306845 3.9590793828186563 0.22620627940115107 0.9994876228780025 0.006649899960032158 12.423345184780715 0.13977302726488103 13.936812383679337 0.09067158226738017 1.000000000000405e-14 13.999999999999824 -3.7328731034175053 SMEAHNILSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SMEAHNILSKR 11 1 Q9NP77;Q9NP77-2 Q9NP77 SSU72 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 1 46050000.0 26913000.0 19137000.0 0.0 True False 26058661.546431422 26778503.898136653 0.0 1.0 1.0276239188425933 0.0 24.63525964873479 -7.003565635634257 1.1164346086737522 1.0310439699501648 2.8505994173882846e-20 0.9836610311357886 0.06110606993213202 0.0912640004461545 0.22237757005208472 0.04610086464515789 0.08438379639731804 9.918234320165669e-08 7.003565635634257 -1.0310439699501648 down SMEAHNILSK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SMEAHNILSKR 11 1 Q9NP77;Q9NP77-2 Q9NP77 SSU72 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 1 58761100.0 43528000.0 8910200.0 6322900.0 True False 56347854.06515543 8414339.537304718 5172197.078432679 1.0 0.1493284824578263 0.09179048899452373 25.747857332488184 -13.569925113890303 0.386755076685386 9.999995632518749 0.08724191662135355 0.9998083856973997 0.005747910074806402 17.684112103254886 0.20288866893641785 131.1044306490431 0.015291880149945536 2.6919989497024574e-14 13.569925113890303 -9.912753715897395 SMEGLK(ub)ALR ddPTM_RPMI8226_Bortezomib_1h_R1 2 SMEGLKALR 9 1 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 1 92725300.0 39721800.0 33177900.0 19825600.0 True False 52075664.466458395 28227886.646441303 17774237.09258387 1.0 0.5420552370411462 0.34131560825368135 25.63410600685669 -13.695430659352347 0.11592766566997738 3.052541979870096 3.3505533046611623e-17 0.9997257455645464 0.004565029312224989 10.773084022497095 0.10097439229533858 5.223710006063433 0.2961873960019534 2.0163658834700108e-14 13.695430659352347 -3.052541979870096 SMEGLK(ub)ALR ddPTM_RPMI8226_Bortezomib_2h_R1 2 SMEGLKALR 9 1 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 1 116914200.0 61845400.0 37544100.0 17524700.0 True False 59882151.629460454 52535654.91989509 12934455.340269264 1.0 0.8773174224763314 0.21599850687238584 25.835622724107935 -6.93814277127172 0.6766223370255178 1.007715642290768 0.047001814862084795 0.9979103605748697 0.01574008951910322 0.08862427730769225 0.058545566204318784 0.015114193549303072 0.05739975785178113 1.1530741304556315e-07 6.93814277127172 -0.9607138274286833 down SMEGLK(ub)ALR ddPTM_RPMI8226_Bortezomib_8h_R1 2 SMEGLKALR 9 1 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 1 123025300.0 72061800.0 43183900.0 7779600.0 True False 109323019.02325723 35477395.64764928 6241958.650080195 1.0 0.3245189893640046 0.0570964715926139 26.704021965544854 -9.125448589241907 0.36063452626029374 1.210116373692172 1.0356003712274073e-18 0.997870512731043 0.018309613442537332 0.5698782164409834 0.1385161738687637 0.24096471046384235 0.07389005986786279 7.491200323275568e-10 9.125448589241907 -1.210116373692172 SMEGLK(ub)ALR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SMEGLKALR 9 1 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 1 81551600.0 39721800.0 24372700.0 17457100.0 True False 54408022.90128276 23295833.52425909 13334092.520260127 1.0 0.4281690876091337 0.24507585111948177 25.697316068379582 -13.999999999999998 0.159333709937584 3.8122573786023937 0.06375636886275518 0.9995381360942426 0.006909969073705439 12.005306300556477 0.1261195785852832 10.434489445011868 0.16511926655202697 1.0000000000000041e-14 13.999999999999998 -3.7485010097396385 SMEGLK(ub)ALR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SMEGLKALR 9 1 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 1 138088200.0 61845400.0 65938600.0 10304200.0 True False 51427190.31576607 65583375.67401264 12458760.578762198 1.0 1.2752665520190143 0.24226018381063893 25.61602799954221 -6.835803737815739 1.30160974134174 1.146610068132676 0.21098436157720157 0.9170157835076795 0.1258250575531493 0.17375882833734732 0.5736179145551132 0.07584645402848703 0.17460023510502792 1.459473662565913e-07 6.835803737815739 -0.9356257065554745 down SMGFIGHYLDQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SMGFIGHYLDQK 12 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 31930700.0 8714300.0 9642400.0 13574000.0 False True 11424531.68940123 8203791.505780809 12169492.69100221 1.0 0.7180855836210452 1.0652071368747742 23.445631692232226 -6.690665465349377 1.863783613668164 0.8233724898774512 1.06402661700021 0.3736884799601282 0.11921316851469985 0.4152258042994292 2.796942488553265 0.05115665510103346 0.13311698877319747 2.0386118045120041e-07 6.690665465349377 0.2406541271227588 SMGFIGHYLDQK ddPTM_RPMI8226_Bortezomib_2h_R1 2 SMGFIGHYLDQK 12 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 28544640.0 9001700.0 4774440.0 14768500.0 False True 8715945.960781464 6680898.790375676 10900186.804496894 1.0 0.7665144805207893 1.2506028437468182 23.055225821037943 -6.775584012143348 1.5533613694331 0.8670339166397341 1.2539003730582357 0.751345959796657 0.09856829852851788 0.2575025328294148 1.226947770466435 0.04999791815731097 0.11840304622633249 1.676547984370092e-07 6.775584012143348 0.3868664564185016 SMGFIGHYLDQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SMGFIGHYLDQK 12 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 28163300.0 6514600.0 15619000.0 6029700.0 False True 9883124.4810553 12831667.418196004 4837927.152088601 1.0 1.2983411716398683 0.48951393472401317 23.236535781246875 -6.806846464915524 1.4277090700625403 1.1632092623295753 0.4763564810157958 0.8514458173232706 0.12871994908286175 0.2111308951207569 0.8487643832755385 0.07090360171085498 0.16426429176445156 1.5601039451446037e-07 6.806846464915524 -0.6868527813137795 down SMGFIGHYLDQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SMGFIGHYLDQK 12 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 36188300.0 8714300.0 11656000.0 15818000.0 False True 11936212.205102682 11140999.37876249 12082114.181935964 1.0 0.9333781259351067 1.0122234737726017 23.508841753755117 -11.900878358328193 8.422908612184074 0.967322997423493 0.9755207204084804 0.0 0.03522463869290933 253570.64136507368 0.009438157544310403 1508856.6729630043 0.010966167601768504 1.256381814777192e-12 11.900878358328193 0.008197722984987332 SMGFIGHYLDQK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SMGFIGHYLDQK 12 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 21599110.0 9001700.0 7264700.0 5332710.0 False True 7485312.392925443 7225563.619169944 6447755.005334812 1.0 0.9652988732973932 0.8613875636544905 22.83563109647222 -6.9514930219740005 0.5422150024681346 1.0015079505499418 0.8203616958270336 0.999313230090488 0.0015433483194203178 0.08289191045593065 0.033525024480097726 0.001692390809737846 0.008608412878368688 1.1181677905993446e-07 6.9514930219740005 -0.18114625472290824 SMGFIGHYLDQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SMGFIGHYLDQK 12 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 18930700.0 6514600.0 7169900.0 5246200.0 False True 8433278.121964278 6770888.762151359 4291445.430557737 1.0 0.8028774415155046 0.5088703785756534 23.007662103339324 -6.965351838215164 0.3519665168946427 1.0277770436049742 0.274019973067433 0.9999202093618371 0.0018025731175636966 0.07784182729021408 0.014440427718836999 0.0040159737789130035 0.0252380931911713 1.0830491398642983e-07 6.965351838215164 -0.7537570705375413 SMGFIGHYLDQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SMGFIGHYLDQKR 13 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 1 21991700.0 6514700.0 6095900.0 9381100.0 True False 8433407.573935572 5756657.806273241 7673836.058214553 1.0 0.6826016359110714 0.909933024218044 23.00768424873533 -9.966228588899837 5.897588331691325 1.00000016304326 0.7962673314513291 0.5171137692095258 0.09280765064530906 1.9884793557644505e-07 3.496523758611805e-08 0.08986069230544402 0.02995354044579568 1.080864893293303e-10 9.966228588899837 -0.2037328315919309 SMGLPTSDEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SMGLPTSDEQK 11 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 7430100.0 2557400.0 1124200.0 3748500.0 False True 2476216.7368499846 1573098.922625554 2766655.3974104733 1.0 0.6352832121741919 1.11729129209019 21.23970616477053 -6.704317497710374 1.8152633706388241 0.7744951635283307 1.1159903532066846 0.4382049588531972 0.15383275236816515 0.38659779886774503 2.479489776440877 0.06752877994586584 0.17276011012314052 1.9755248739970528e-07 6.704317497710374 0.3414951896783539 SMGSQEDDSGNK(ub)PSSYS ddPTM_RPMI8226_Bortezomib_1h_R1 1 SMGSQEDDSGNKPSSYS 17 1 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 16605900.0 6852300.0 6828400.0 2925200.0 True False 8983431.657767586 5809629.336894728 2622528.3644997566 1.0 0.6467049072356879 0.29192946130248226 23.09883522697622 -7.415493193719313 0.2973202191331864 1.0852861574158332 7.020140289502095e-12 0.999786852316668 0.004220278563633048 0.11777829658784203 0.026448977743427107 0.018630896298038897 0.05851808314813728 3.841552796286634e-08 7.415493193719313 -1.085286157408813 down SMGSQEDDSGNK(ub)PSSYS ddPTM_RPMI8226_Bortezomib_2h_R1 1 SMGSQEDDSGNKPSSYS 17 1 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 18553000.0 6401200.0 6389700.0 5762100.0 True False 6197997.409839727 8941140.53184531 4252833.150705321 1.0 1.4425853934128245 0.6861624601445734 22.563370721342178 -6.748124891067976 1.6568814467586148 1.2608303642634349 0.6848797901111858 0.6408322645752431 0.1859621630011805 0.3033224060047727 1.6377592429627825 0.08868607211331407 0.21572321391074956 1.7859739043531652e-07 6.748124891067976 -0.575950574152249 SMGSQEDDSGNK(ub)PSSYS ddPTM_RPMI8226_Bortezomib_8h_R1 1 SMGSQEDDSGNKPSSYS 17 1 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 47778300.0 13493000.0 24933000.0 9352300.0 True False 20469867.470432453 20483511.347581852 7503813.805741296 1.0 1.000666534708596 0.36657852409548447 24.286998426056552 -6.906656797475665 0.9181793788326437 1.021768549059069 0.29022782237901473 0.9895980264669054 0.030470039030099243 0.1066714383582411 0.15105852775332473 0.02454094359803844 0.06627483221564326 1.239775936185638e-07 6.906656797475665 -0.7315407266800544 down SMGSQEDDSGNK(ub)PSSYS ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SMGSQEDDSGNKPSSYS 17 1 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 16389900.0 6852300.0 6126800.0 3410800.0 True False 9385780.48644471 5856097.717381771 2605239.287631006 1.0 0.6239329511103912 0.2775730043328404 23.16204528849911 -7.571582451339778 0.29002454507622927 1.1005324901636002 2.88538629032627e-17 0.9996859912096253 0.005227708227161978 0.12674907475682218 0.033501600170222225 0.027538618785267383 0.07011204753033397 2.6817454266189885e-08 7.571582451339778 -1.1005324901636002 down SMGSQEDDSGNK(ub)PSSYS ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SMGSQEDDSGNKPSSYS 17 1 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 18322200.0 6401200.0 9640600.0 2280400.0 True False 5322881.421242023 9588664.174290735 2757221.096621699 1.0 1.8014048060558427 0.5179940859885507 22.343775996776454 -6.737867771548458 1.6944710003258123 1.4780167376449096 0.5175868811996325 0.5953014115152175 0.33673885564684186 0.3217098156919548 1.8128518801562672 0.1572655354139473 0.38682721152915983 1.8286568975504319e-07 6.737867771548458 -0.9604298564452771 SMGSQEDDSGNK(ub)PSSYS ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SMGSQEDDSGNKPSSYS 17 1 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 35905400.0 13493000.0 16324000.0 6088400.0 True False 17466954.48679337 15415555.050050745 4980373.672259489 1.0 0.8825554026436794 0.2851311988031521 24.058124748149 -6.939421938258291 0.6649214599900016 1.006777316481631 0.12672910009379204 0.9980871740498823 0.013689521275126994 0.0880314027256768 0.05581845649244496 0.013268044246606261 0.05155147879431601 1.1496828732207035e-07 6.939421938258291 -0.8800482163878389 down SMIEISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SMIEISR 7 0 P49368;B4DUR8;P49368-2;E9PRC8;Q5SZX6;Q5SZX9;E9PM09;Q5SZW8 P49368 CCT3 T-complex protein 1 subunit gamma 0 12619900.0 3251200.0 4745000.0 4623700.0 False True 4262354.684665587 4037064.4958651303 4145283.8776622224 1.0 0.9471441948247599 0.972533771667444 22.023219218877763 -10.117013481025568 4.413469117456135 1.0000050906232607 0.9598389832439047 0.7693772010838632 0.010365251349063931 14454529.094733048 0.3288971349670042 747.7821571146336 0.0035483012352047452 7.638120735598603e-11 10.117013481025568 -0.040166107379356 SMIEISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SMIEISR 7 0 P49368;B4DUR8;P49368-2;E9PRC8;Q5SZX6;Q5SZX9;E9PM09;Q5SZW8 P49368 CCT3 T-complex protein 1 subunit gamma 0 8494400.0 2590100.0 1194100.0 4710200.0 False True 2507878.69324906 1670910.3571492361 3476457.317028893 1.0 0.6662644256467218 1.3862143039004011 21.25803613561383 -6.780638011670494 1.5333053753790868 0.811194541532996 1.3920425976100113 0.7697105428351507 0.14117178709859535 0.24955989569471163 1.1589162856059316 0.07251290384605386 0.1710146573578382 1.6571506378446338e-07 6.780638011670494 0.5808480560770153 SMIEISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SMIEISR 7 0 P49368;B4DUR8;P49368-2;E9PRC8;Q5SZX6;Q5SZX9;E9PM09;Q5SZW8 P49368 CCT3 T-complex protein 1 subunit gamma 0 33511100.0 5561200.0 24866000.0 3083900.0 False True 8436746.978178972 20428468.021055255 2474365.813278615 1.0 2.421367865350471 0.2932843452195948 23.008255404380588 -6.726637272420162 1.7352284681374115 1.858496200447198 0.2952048877796156 0.5438802590965698 0.5976758431386886 0.34249451836422495 2.0186770483670076 0.2731175534621211 0.6803860972163581 1.8765611784862346e-07 6.726637272420162 -1.5632913126675825 SMIEISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SMIEISR 7 0 P49368;B4DUR8;P49368-2;E9PRC8;Q5SZX6;Q5SZX9;E9PM09;Q5SZW8 P49368 CCT3 T-complex protein 1 subunit gamma 0 14084700.0 3251200.0 5963900.0 4869600.0 False True 4453256.50037638 5700395.178020039 3719500.7725600875 1.0 1.28005094194288 0.835231649523382 22.086429280400655 -6.736504922434446 1.6994757928842252 1.1672920510594023 0.8351605497871286 0.5892671830550626 0.11767814728125997 0.3241218231143669 1.8366988896004572 0.05481022297042702 0.13501970840106017 1.8344043752660372e-07 6.736504922434446 -0.33213150127227364 SMIEISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SMIEISR 7 0 P49368;B4DUR8;P49368-2;E9PRC8;Q5SZX6;Q5SZX9;E9PM09;Q5SZW8 P49368 CCT3 T-complex protein 1 subunit gamma 0 6137900.0 2590100.0 2530400.0 1017400.0 False True 2153782.9108852977 2516768.2329549245 1230133.6360738978 1.0 1.1685338481585519 0.5711502444637095 21.038441411048105 -6.831365214152668 1.3218610291532702 1.0899698535816278 0.5546289416429159 0.9085681586858988 0.07604197966758125 0.1791312525881468 0.6116710380338441 0.04516183526113644 0.10392439320005024 1.474466079191986e-07 6.831365214152668 -0.5353409119387119 SMIMFGSQENK(ub)DPLSASSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SMIMFGSQENKDPLSASSR 19 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 10959100.0 2804100.0 3697700.0 4457300.0 True False 3676202.254943028 3146017.5735217105 3996101.3534407136 1.0 0.8557792404625099 1.087018906010285 21.809784711407143 -6.7380807070952065 1.693909406024021 0.9139967145813519 1.0870930745518959 0.5961823115666764 0.06059880245654743 0.3213164299480461 1.8095596599886385 0.028310921412777905 0.06961435824707835 1.8277605227870084e-07 6.7380807070952065 0.17309635997054396 SMIMFGSQENK(ub)DPLSASSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SMIMFGSQENKDPLSASSR 19 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 14024700.0 4479100.0 4573800.0 4971800.0 True False 4336913.422235383 6400142.192051904 3669536.429197118 1.0 1.4757366746678258 0.8461170588242277 22.04823721230421 -6.704610914178446 1.814511463665477 1.2940685188744765 0.8478238340124701 0.4394664922445347 0.20064992937536974 0.38599601466282407 2.4738407852919995 0.08811616018707806 0.22532344657887357 1.9741906277924253e-07 6.704610914178446 -0.4462446848620064 SMIMFGSQENK(ub)DPLSASSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SMIMFGSQENKDPLSASSR 19 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 20796800.0 8197400.0 6337600.0 6261800.0 True False 12436055.110214414 5206605.764105197 5024152.485355567 1.0 0.4186702067465692 0.4039988919982314 23.568025579301388 SMIMFGSQENK(ub)DPLSASSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SMIMFGSQENKDPLSASSR 19 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 13839000.0 4479100.0 6357500.0 3002400.0 True False 3724570.107774348 6323250.885635045 3630187.958470884 1.0 1.6977129447601038 0.9746595857850926 21.828642487738485 -6.654321415467009 1.9935989494458706 1.4511964146577094 0.9777221707795011 0.2116407251450051 0.29747852546147746 0.4979723051102706 3.798549612438131 0.12082714371730467 0.32948904295525766 2.2165553699919458e-07 6.654321415467009 -0.47347424387820836 SMLALLLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SMLALLLGR 9 0 Q9BTE7;H0YCN4;E9PM04 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 0 4039900.0 1078100.0 1461300.0 1500500.0 False True 1413399.5403352499 1243279.7361027857 1345242.653812348 1.0 0.8796378523003391 0.951778046774562 20.43073791424729 -10.17769687045069 4.62742231332363 1.0000132020822758 0.9157079495371598 0.645435363666939 0.02945111107071387 4.011941662130542e-06 7.12935066516833e-07 0.028520381258887024 0.009505305224941451 6.642065125581184e-11 10.17769687045069 -0.084305252545116 SMLALLLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SMLALLLGR 9 0 Q9BTE7;H0YCN4;E9PM04 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 0 4178100.0 1451500.0 1184000.0 1542600.0 False True 1405422.9270109294 1656777.374478434 1138546.7829919693 1.0 1.1788461271242303 0.8101097264817249 20.422572908230652 -6.774862540066856 1.5562708468501816 1.101945382506099 0.8076653695542152 0.748647660003986 0.07548258688238522 0.25864591544713095 1.2369618575134695 0.03821938831959456 0.09056231106865277 1.6793354658433303e-07 6.774862540066856 -0.2942800129518838 SMLALLLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SMLALLLGR 9 0 Q9BTE7;H0YCN4;E9PM04 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 0 4632860.0 956060.0 1120700.0 2556100.0 False True 1450412.9173483765 920702.3289309342 2050885.7146215725 1.0 0.6347863549189486 1.4140012751478879 20.46803224818922 -6.7792462309233725 1.5386950616619097 0.793003474031307 1.4200401300535614 0.7647405129004485 0.15439697007463196 0.2517533495035195 1.1772407424193618 0.07903432413547849 0.18661441626355338 1.6624698165062425e-07 6.7792462309233725 0.6270366560222544 SMLALLLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SMLALLLGR 9 0 Q9BTE7;H0YCN4;E9PM04 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 0 7937200.0 1078100.0 1976500.0 4882600.0 False True 1476702.7045570158 1889171.694588542 3729430.4403034872 1.0 1.2793175557670964 2.525512026757105 20.49394797577018 -6.942374960307176 0.6370845252784941 0.9863810638915629 2.886432107431053 0.9984587368572616 0.026035523949473248 0.08669964404577983 0.049799444281445705 0.02582539012282742 0.10618597745310433 1.1418920246036351e-07 6.942374960307176 1.9000510435394902 up SMLALLLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SMLALLLGR 9 0 Q9BTE7;H0YCN4;E9PM04 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 0 3051330.0 1451500.0 572230.0 1027600.0 False True 1206986.562352808 569147.2834112381 1242466.408914428 1.0 0.4715440098204454 1.0293953948355965 20.20297818366493 -11.028058561067862 13.509795640787623 1.5972947756072116 0.7504697023277322 0.21059503496857013 0.22774187426533368 0.041254515712017575 8.568179967408935e-05 0.0022203363141429203 0.07350337385530838 9.374355928611253e-12 11.028058561067862 -0.8468250732794793 SMLEVNYPMENGIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SMLEVNYPMENGIVR 15 0 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 0 15090600.0 3295100.0 5705700.0 6089800.0 False True 4319908.009793794 4854431.800644402 5459685.913486474 1.0 1.1237349938097694 1.263843095989233 22.04256916059548 -6.969509293818493 0.2696524549328456 0.965023061988842 1.426765119654921 0.9999782941389368 0.0005021211056770997 0.0764623078206753 0.009598669206306478 0.002752290911028672 0.013037069536426131 1.0727306913591556e-07 6.969509293818493 0.4617420576660789 SMLEVNYPMENGIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SMLEVNYPMENGIVR 15 0 P61160;P61160-2;F5H6T1 P61160 ACTR2 Actin-related protein 2 0 13943900.0 3295100.0 5102000.0 5546800.0 False True 4513387.516729274 4876576.769942185 4236760.079931879 1.0 1.080469326391035 0.9387095755079637 22.10577922211837 -6.752739834522496 1.6399416624009269 1.047160975825383 0.9383719506939446 0.6605867969970266 0.03381913745989655 0.29528727895023754 1.5633283708863999 0.016285846029082732 0.03942089708319799 1.7670960881536244e-07 6.752739834522496 -0.1087890251314384 SMLSNFAQAPQLSVPGGLLGMPGVNIAYLNTGIGGHK ddPTM_RPMI8226_Bortezomib_8h_R1 2 SMLSNFAQAPQLSVPGGLLGMPGVNIAYLNTGIGGHK 37 0 A0A0U1RRM1;Q8WXI9 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 0 332506000.0 158237000.0 80645000.0 93624000.0 False True 240057097.67426205 66253269.66773909 75119175.36314309 1.0 0.2759896304238394 0.31292211765833183 27.838802351325693 -10.094011282951238 5.378379649598157 1.0000094574248801 0.2944558740406369 0.9979491283478442 0.015077624777634198 1.7098669271864437e-06 2.8803141370276625e-07 0.014599042996126741 0.004866282471784167 8.053575177749408e-11 10.094011282951238 -0.7055535833842432 SMMGGGLAEIPGLSINFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SMMGGGLAEIPGLSINFAK 19 0 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ET17;A0A2R8Y7L2;E7EPL9;E7ER27 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 9951900.0 3633500.0 2663900.0 3654500.0 False True 3518156.5313773463 3727609.1620549806 2697276.8173500234 1.0 1.0595347673730806 0.7666733396578147 21.746388242588274 -6.853764132162535 1.2167260232442232 1.031904505232639 0.7540833056051094 0.9456138994423327 0.029473517143460515 0.15336418951029288 0.43501085403659123 0.018934593489591412 0.04393624862578188 1.4003476529693986e-07 6.853764132162535 -0.2778211996275296 SMPEQTGEK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 SMPEQTGEK 9 0 A0A0B4J213;P62888;A0A0C4DH44 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 1 17850400.0 8812600.0 5112000.0 3925800.0 True False 13369358.487358857 4199723.659761701 3149863.9092607307 1.0 0.3141305294291173 0.23560322002278752 23.672426905311436 -13.999999999999998 0.30588975079314 7.472876299761473 0.21743560124114622 0.9996629265433155 0.00630340454445721 16.982354419724487 0.17583246083827758 69.80525592769396 0.027679383381295327 1.0000000000000041e-14 13.999999999999998 -7.255440698520327 SMPEQTGEK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SMPEQTGEK 9 0 A0A0B4J213;P62888;A0A0C4DH44 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 1 15666700.0 8812600.0 4535500.0 2318600.0 True False 11408084.422316408 4283095.437975075 1896638.5908450235 1.0 0.37544387641421345 0.16625390561931971 23.443553227403886 -11.876003950140326 0.18891883934010098 2.463135703651858 2.0699264250950395e-20 0.9994287372821036 0.00846518602016665 5.000814559008295 0.11945841309463871 3.0375967802836557 0.1421315181152805 1.3304423168394235e-12 11.876003950140326 -2.463135703651858 SMQNHAAVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SMQNHAAVFR 10 0 P31040-2;P31040;A0A087X1I3;P31040-3 P31040-2 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0 2073250.0 605670.0 203480.0 1264100.0 False True 586443.3373769964 284730.6251341819 932994.2878128785 1.0 0.48552111855802726 1.5909368021570702 19.161632195078816 -6.78015230748358 1.5352281453450096 0.708739646981274 1.599739770355981 0.7679117840324761 0.21758179011568093 0.2503566172657295 1.16550902694156 0.11162352357108177 0.26335652392073367 1.6590049907923695e-07 6.78015230748358 0.891000123374707 SMQNWHQLENLSNFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SMQNWHQLENLSNFIK 16 0 B4DDF4;B4DUT8;Q99439;A0A087X271;H3BVI6;Q99439-2;K7ES69;A0A087X1X5;H3BQH0;A0A087WV51 B4DDF4 CNN2 Calponin;Calponin-2 0 8325500.0 2492900.0 2353200.0 3479400.0 False True 3268216.041277938 2002111.7327017584 3119385.064761542 1.0 0.6126007912007226 0.9544610960118168 21.6400719234866 -10.235402156014372 7.802028864540746 1.0000002344128285 0.7835309436062697 0.348366526450845 0.13956388501658434 5.690470788219512e-07 5.5876615050185006e-08 0.13513229658590378 0.045044050200103165 5.815644405890284e-11 10.235402156014372 -0.21646929080655875 SMQNWHQLENLSNFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SMQNWHQLENLSNFIK 16 0 B4DDF4;B4DUT8;Q99439;A0A087X271;H3BVI6;Q99439-2;K7ES69;A0A087X1X5;H3BQH0;A0A087WV51 B4DDF4 CNN2 Calponin;Calponin-2 0 31815200.0 11483000.0 5044200.0 15288000.0 False True 11118478.45047642 7058375.365155502 11283614.169830956 1.0 0.6348328502496721 1.0148523667235656 23.406456034813804 -10.97511955648631 11.959639835323566 1.088281016588521 0.8248426084866485 0.2207341451604028 0.15514231794337086 0.07997751085770995 0.00016638246961761863 0.032897769076700466 0.0500719678072243 1.0589621644299595e-11 10.97511955648631 -0.2634384081018726 SMQNWHQLENLSNFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SMQNWHQLENLSNFIK 16 0 B4DDF4;B4DUT8;Q99439;A0A087X271;H3BVI6;Q99439-2;K7ES69;A0A087X1X5;H3BQH0;A0A087WV51 B4DDF4 CNN2 Calponin;Calponin-2 0 22716700.0 2492900.0 8001800.0 12222000.0 False True 3414592.4980894034 7648254.017585932 9335415.319991235 1.0 2.239873139141911 2.7339764042751105 21.703281985009493 -9.747736388997808 0.24472967683472305 1.118176118965399e-16 3.0377398440285774 0.9991263783573838 0.02155866775384809 1.168774287571764 0.1045476253843613 1.0725237204282707 0.22517126926333722 1.7875722783310544e-10 9.747736388997808 3.0377398440285774 SMQNWHQLENLSNFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SMQNWHQLENLSNFIK 16 0 B4DDF4;B4DUT8;Q99439;A0A087X271;H3BVI6;Q99439-2;K7ES69;A0A087X1X5;H3BQH0;A0A087WV51 B4DDF4 CNN2 Calponin;Calponin-2 0 19539900.0 11483000.0 4276800.0 3780100.0 False True 9548623.283153504 4253760.029521664 4570501.432792362 1.0 0.4454841188495215 0.47865553988877435 23.18686131024808 -9.97596479360174 5.351697737740442 1.00000163380219 0.4620698293680702 0.9971561880234193 0.013542175937641097 37243041.16934363 23.09868323950639 816.8759377229203 0.0046358470232785364 1.0569031843668188e-10 9.97596479360174 -0.5379318044341198 SMTLK(ub)EAIK ddPTM_RPMI8226_Bortezomib_1h_R1 2 SMTLKEAIK 9 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 69912240.0 12821440.0 27713600.0 29377200.0 True False 16809032.003001563 23578838.906766716 26337529.150000766 1.0 1.4027481714923429 1.566867690257102 24.002733309387644 -11.764574316379742 0.15408195186406706 4.3869707751718055e-16 1.763529351583951 0.9995868877164393 0.0048406309976569166 4.8344319974737315 0.10084884034251089 1.7371065846219587 0.15216728739218136 1.719593059660171e-12 11.764574316379742 1.7635293515839505 SMTLK(ub)EAIK ddPTM_RPMI8226_Bortezomib_2h_R1 2 SMTLKEAIK 9 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 114052900.0 22563900.0 36818300.0 54670700.0 True False 21847621.34535443 51520039.19489808 40350803.584156 1.0 2.3581532460902452 1.8469197605686256 24.38097287940351 -9.939895104426466 5.623909181648307 0.9999987964910679 2.102536503331005 0.8611371101951893 0.2087101964976234 3.1497538546470358e-06 5.932692483904343e-07 0.20208300158558704 0.06736092626744214 1.1484309696635382e-10 9.939895104426466 1.1025377068399371 SMTLK(ub)EAIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SMTLKEAIK 9 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 33305700.0 20939000.0 8275900.0 4090800.0 True False 31765993.84594863 6799000.985098168 3282251.586938668 1.0 0.21403394517012095 0.10332595299414124 24.920979820897593 -13.999999999999998 0.27611222675841074 7.270447405516401 0.06870111476063713 0.9995966099927581 0.008017136836442756 15.191876918740288 0.16640376176810606 53.66768989030855 0.044617196350682176 1.0000000000000041e-14 13.999999999999998 -7.2017462907557634 SMTLK(ub)EAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SMTLKEAIK 9 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 63557810.0 12821440.0 18813070.0 31923300.0 True False 17561872.854387816 17981846.360896982 24383674.0210012 1.0 1.0239139361724872 1.3884438307449063 24.065943370910535 -6.920228054768743 0.8230179190812121 0.9920230804826926 1.447540164679999 0.9942444365252495 0.01348476993521477 0.09803761963364065 0.10491490948809451 0.011632605854214198 0.034922347217438796 1.201633272645573e-07 6.920228054768743 0.4555170841973064 SMTLK(ub)EAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SMTLKEAIK 9 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 80140500.0 22563900.0 50988100.0 6588500.0 True False 18762882.600256674 50713416.98495454 7966124.888217887 1.0 2.7028585140889168 0.4245682850517282 24.161378154837788 -6.706630624884273 1.8071618162089444 2.05045923182335 0.4304215584015094 0.4491143324285668 0.7179646338788095 0.3818871177372582 2.428991762600088 0.31641008172273105 0.8071478791217874 1.9650308597051297e-07 6.706630624884273 -1.6200376734218405 SMTLK(ub)EAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SMTLKEAIK 9 1 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 1 77941500.0 20939000.0 46967500.0 10035000.0 True False 27105948.26939644 44353717.33724932 8208732.967795134 1.0 1.636309377426438 0.30283880446503614 24.692106142990042 -6.776941293264206 1.5476819203835748 1.361730866852449 0.2932542132720903 0.7564319103830428 0.2687625098990978 0.2553682669277305 1.2079560801414506 0.13680142846177518 0.3236432670457792 1.6713165230208178e-07 6.776941293264206 -1.0684766535803587 SMVDASEEKTPEQIMQEK(ub)QIEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SMVDASEEKTPEQIMQEKQIEAK 23 2 B3KVZ3;Q9H3R5;D6RBJ6 B3KVZ3 CENPH Centromere protein H 1 20228400.0 6503800.0 7503800.0 6220800.0 True False 8419297.309064452 7086206.933629673 5088678.230798206 1.0 0.8416625133311855 0.6044065251525911 23.005268397505112 -6.965274860224316 0.3533054748045548 1.0220732967459876 0.415949091519117 0.99991869606895 0.001465843552785991 0.07786783900033503 0.01453190942121392 0.0032303596569351824 0.020348883339361475 1.0832411255776103e-07 6.965274860224316 -0.6061242052268705 SMVK(ub)EDEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SMVKEDEAR 9 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 15073500.0 3464900.0 6239500.0 5369100.0 True False 4542517.454139332 5308590.921380509 4813557.036043907 1.0 1.1686451345482665 1.0596672626227537 22.115060627196197 -10.45068635709012 5.286164612528396 0.9998575254973283 1.1141561985855113 0.5940003712822036 0.04449002991198557 7.479673349158421e-05 7.772496966590406e-06 0.04313092221003447 0.01435909541011509 3.542530865794717e-11 10.45068635709012 0.11429867308818298 SMVK(ub)EDEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SMVKEDEAR 9 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 15408500.0 4066200.0 6499300.0 4843000.0 True False 3937120.7067253496 9094504.38340175 3574473.0131142912 1.0 2.309937911699433 0.9078901256464941 21.908709513552026 -6.661432944407053 1.967851854886716 1.8421621591296657 0.9137130133727602 0.24184886079672485 0.5575440860522944 0.48095264408613564 3.581818529718128 0.22878900983977657 0.6181533351466902 2.1805550515310002e-07 6.661432944407053 -0.9284491457569055 SMVK(ub)EDEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SMVKEDEAR 9 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 10069830.0 1995930.0 3691300.0 4382600.0 True False 3027971.7320284783 3032558.674741463 3516377.189038184 1.0 1.001514856517472 1.1612978918672126 21.529920306268462 -6.908974614942465 0.9026858319795666 0.9948909337806192 1.1815008322958125 0.9905289056327591 0.007365338410523002 0.10510007119813447 0.14247285222449751 0.005999694596880796 0.016446608261892995 1.2331769118605614e-07 6.908974614942465 0.18660989851519327 SMVK(ub)EDEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SMVKEDEAR 9 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 12898500.0 3464900.0 4759300.0 4674300.0 True False 4745967.165401735 4549018.389099545 3570326.610230331 1.0 0.9585018670719102 0.752286411979024 22.17827068871909 -6.939942966332911 0.6600947838818687 1.0023169707204103 0.696770012958089 0.998156403237266 0.004651164528106906 0.08779270302214681 0.05472842353399874 0.004525599244115722 0.017753022256220555 1.1483044125249363e-07 6.939942966332911 -0.3055469577623212 SMVK(ub)EDEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SMVKEDEAR 9 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 13880700.0 4066200.0 7170600.0 2643900.0 True False 3381225.4632028877 7131970.554547336 3196727.2659875974 1.0 2.1092857108060254 0.9454345179807906 21.689114788986302 -6.6570927156480195 1.983303754583798 1.715769792917544 0.950339330204669 0.22313710399587894 0.47264664172423954 0.4914802347693498 3.713256806196312 0.19274735408881316 0.5237646856227002 2.2024562200205562e-07 6.6570927156480195 -0.765430462712875 SMVK(ub)EDEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SMVKEDEAR 9 1 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 6280250.0 1995930.0 3845100.0 439220.0 True False 2583770.7306622323 3631116.804885456 359286.4667777756 1.0 1.4053556539650034 0.13905508817560172 21.30104662836091 -6.820575943748756 1.369384365727937 1.2183570672284831 0.11106801139903422 0.8857035189591815 0.17850500304975453 0.1927330996432077 0.7100056815792585 0.10243186311019306 0.23605299133465008 1.511555355183627e-07 6.820575943748756 -1.1072890558294488 down SMVPVQVQLDVPVVK ddPTM_RPMI8226_Bortezomib_1h_R1 2 SMVPVQVQLDVPVVK 15 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 45639300.0 13224400.0 19442900.0 12972000.0 False True 17337316.465271782 16542095.107830616 11629781.87621047 1.0 0.9541323849608405 0.6707948083837529 24.047377274313767 -6.9352215279631215 0.7026089462861541 1.0035897573483175 0.6040529865872512 0.9974686484189592 0.007324847570014318 0.09001576161095516 0.0650524318987323 0.006894342759563942 0.024942350078897342 1.1608563250902542e-07 6.9352215279631215 -0.3995367707610663 SMVPVQVQLDVPVVK ddPTM_RPMI8226_Bortezomib_2h_R1 2 SMVPVQVQLDVPVVK 15 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 57393400.0 19290200.0 15800800.0 22302400.0 False True 18677843.159921616 22110141.840083476 16460732.382341553 1.0 1.183763117120867 0.8812972804944911 24.15482453242083 -6.7423281723621225 1.6789783523775752 1.109047981942938 0.8810570094735657 0.615008027383088 0.07720580698313656 0.31361981215363327 1.7369155913279775 0.03637098674582738 0.08899625965175927 1.8099718799240885e-07 6.7423281723621225 -0.22799097246937228 SMVPVQVQLDVPVVK ddPTM_RPMI8226_Bortezomib_8h_R1 2 SMVPVQVQLDVPVVK 15 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 90654500.0 19136400.0 45318900.0 26199200.0 False True 29031317.858236406 37231388.216818176 21020916.636482716 1.0 1.2824560152117017 0.7240772444134471 24.791106727887726 -6.769186448718505 1.577591391661319 1.162178293067733 0.7210347158318956 0.7274261067941414 0.11901598912265127 0.2677496501092161 1.314993732402688 0.05946957497645979 0.14166683505895986 1.701427904689702e-07 6.769186448718505 -0.4411435772358373 SMVPVQVQLDVPVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SMVPVQVQLDVPVVK 15 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 65590400.0 13224400.0 24919800.0 27446200.0 False True 18113818.05597239 23818760.837241374 20963972.832232334 1.0 1.3149497672793495 1.1573469915317056 24.11058733583666 -10.177981136431795 4.261057232268897 0.9999306956225841 1.236148379363874 0.749593816320635 0.0643410638844158 6688801.735850645 16105838.318798633 2608.1248928456175 0.02202565853097025 6.63771900689007e-11 10.177981136431795 0.23621768374128982 SMVPVQVQLDVPVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SMVPVQVQLDVPVVK 15 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 45287600.0 19290200.0 14302100.0 11695300.0 False True 16040656.00075655 14225051.748555409 14140733.157042531 1.0 0.8868123440764824 0.8815557890135908 23.935229807855105 SMVPVQVQLDVPVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SMVPVQVQLDVPVVK 15 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 57836200.0 19136400.0 24307300.0 14392500.0 False True 24772447.034838274 22954577.387166053 11773212.679520829 1.0 0.9266172758340873 0.4752543284465918 24.562233049980176 -6.9353114064920165 0.7018223313445845 1.005702323383655 0.3686714385294119 0.9974830850956234 0.011639842383932082 0.08997206571699376 0.06484594853445479 0.010962252581084487 0.03971582988607706 1.1606161072944467e-07 6.9353114064920165 -0.6370308848542432 down SMVQK(ub)MIFSLNK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 SMVQKMIFSLNK 12 1 A6NL08 A6NL08 OR6C75 Olfactory receptor 6C75 2 6097500.0 1286300.0 2159600.0 2651600.0 True False 1686351.7565469195 1837396.098054869 2377237.867943239 1.0 1.0895687041102489 1.409692763513955 20.68547406912418 -6.9474642177820165 0.5860304948439418 0.9962536499980796 1.5190063077191618 0.9989868947292962 0.0055975955225314586 0.08452042289865135 0.04030306330242944 0.005827246706388308 0.02678706802893771 1.128588919946025e-07 6.9474642177820165 0.5227526577210821 SMVQK(ub)MIFSLNK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 SMVQKMIFSLNK 12 1 A6NL08 A6NL08 OR6C75 Olfactory receptor 6C75 2 28115900.0 8499100.0 4869800.0 14747000.0 True False 8229300.722672126 6814336.5356715135 10884318.299483055 1.0 0.8280577858696648 1.3226297915564351 22.97233841348326 -6.8128101306647855 1.4027313641382393 0.9065988157766298 1.3318456014436844 0.8670212534235004 0.0747588360810315 0.20299834113563797 0.7866994019416351 0.041900193328681334 0.09680431224439373 1.5388272536123256e-07 6.8128101306647855 0.42524678566705454 SMVQK(ub)MIFSLNK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 SMVQKMIFSLNK 12 1 A6NL08 A6NL08 OR6C75 Olfactory receptor 6C75 2 24459600.0 4417100.0 12496000.0 7546500.0 True False 6701063.633265191 10265991.168306375 6054930.9672515495 1.0 1.5319942818247976 0.9035775958302901 22.675958676334606 -6.682356403258395 1.8933465588423173 1.335892829836354 0.9059183897209173 0.3348915112338736 0.2253583983604554 0.433382746951919 3.005631610070631 0.09543312151653535 0.2509566925222211 2.077990686560348e-07 6.682356403258395 -0.4299744401154366 SMVQK(ub)MIFSLNK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SMVQKMIFSLNK 12 1 A6NL08 A6NL08 OR6C75 Olfactory receptor 6C75 2 7172200.0 1286300.0 1712800.0 4173100.0 True False 1761879.8709504607 1637122.8325278296 3187499.727692317 1.0 0.9291909508249675 1.809147025428467 20.74868413064707 -6.887412218369735 1.0375404255432052 0.949744505524563 1.8811106639113706 0.9791906976396534 0.05758249608166635 0.12126908670919015 0.2342988485218488 0.042423312997650564 0.10482595938708669 1.295948614236461e-07 6.887412218369735 0.9313661583868076 SMYEEEINETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SMYEEEINETR 11 0 P20700;E9PBF6;A0A0D9SFE5 P20700 LMNB1 Lamin-B1 0 7127550.0 2030600.0 932450.0 4164500.0 False True 1966139.7144942433 1304782.147662513 3073692.5176779786 1.0 0.66362636288955 1.5633133774873342 20.9069344129997 -6.805449700031982 1.4335998426279453 0.8156699128743797 1.5774631690044216 0.8476052477098467 0.1448965737063969 0.21307250726351076 0.8638864414884925 0.07949338602929204 0.18429024299093014 1.565129581967903e-07 6.805449700031982 0.7617932561300419 SNAALALQLAHCWLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNAALALQLAHCWLQR 16 0 Q05932-3;Q05932-2;Q05932-4;Q05932 Q05932-3 FPGS Folylpolyglutamate synthase, mitochondrial 0 2265570.0 609770.0 0.0 1655800.0 False True 799414.3750210804 0.0 1484473.699555142 1.0 0.0 1.8569514709014294 19.60858398988364 -6.760431513509387 1.610682387373632 0.41944504040936376 1.863913582750537 0.6927461692972594 0.4206323718617222 0.28221601763193416 1.443072032917889 0.20603280729900192 0.4949508504136163 1.7360750133235232e-07 6.760431513509387 1.4444685423411734 SNAALALQLAHCWLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNAALALQLAHCWLQR 16 0 Q05932-3;Q05932-2;Q05932-4;Q05932 Q05932-3 FPGS Folylpolyglutamate synthase, mitochondrial 0 6557470.0 609770.0 1593500.0 4354200.0 False True 835218.4474146491 1523093.9010001717 3325827.637563895 1.0 1.823587476683238 3.981985369047732 19.671794051406533 -6.954443177799446 0.5077277620777519 0.9595223792800174 4.940376714407403 0.9995054137922758 0.027963414502551607 0.08174912806892133 0.028946838542161627 0.03233616279246898 0.17811229647660148 1.1105978341741918e-07 6.954443177799446 3.9808543351273857 SNAHYNLQNAFNLAEQHLGLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNAHYNLQNAFNLAEQHLGLTK 22 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 16028300.0 7256800.0 2738500.0 6033000.0 False True 7026436.856171492 3831997.3310888424 4452776.313879519 1.0 0.5453685003549281 0.6337175448988112 22.744361845662347 -10.106842587876747 5.3800001189065085 1.000006428068034 0.5895430226266688 0.9664188850326941 0.036068346399931075 2.7809694344733953e-06 4.616945336541917e-07 0.034923572944402355 0.0116410087442357 7.819111606933176e-11 10.106842587876747 -0.4104634054413653 SNAHYNLQNAFNLAEQHLGLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNAHYNLQNAFNLAEQHLGLTK 22 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 6941500.0 1059100.0 1084800.0 4797600.0 False True 1450677.8911013226 1036869.9490461169 3664505.6896735355 1.0 0.7147485705865056 2.5260643400938054 20.46829578790283 -6.866634826258635 1.1518275710666883 0.8415468118221036 2.6255398953111273 0.9612033718828423 0.15662967857361085 0.1401180304837476 0.3495620613483916 0.10574026550742738 0.24896877710310358 1.3594560560840957e-07 6.866634826258635 1.7839930834890239 up SNAHYNLQNAFNLAEQHLGLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNAHYNLQNAFNLAEQHLGLTK 22 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 20509000.0 7256800.0 2360800.0 10891400.0 False True 6034350.730748787 2348081.90181789 13168741.38385618 1.0 0.38911922866083104 2.182296318434594 22.524767121096623 -6.814772818818505 1.3943479216484707 0.6688985985763135 2.2172194766089386 0.8719282365339669 0.26638063746056667 0.20036575807520612 0.7668089879294958 0.15017800286821542 0.34670832301281385 1.5318885891787558e-07 6.814772818818505 1.5483208780326252 up SNDLFPVHHLDNNEFCPGDFVVDK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNDLFPVHHLDNNEFCPGDFVVDKR 25 1 Q9C0C9;K7ES11 Q9C0C9 UBE2O E2/E3 hybrid ubiquitin-protein ligase UBE2O 1 10635900.0 1870400.0 5623100.0 3142400.0 True False 2561937.4256594456 5374652.848894933 2400229.83975949 1.0 2.0978860744467602 0.9368807433466757 21.288803808160147 -6.658817022031568 1.9769012491572542 1.7074044299957496 0.9417232475996606 0.23051399805842088 0.46759246636484525 0.48735736751085396 3.660117038224666 0.19116858261791872 0.5183415182401444 2.1937290077148623e-07 6.658817022031568 -0.765681182396089 SNEEGSEEK(ub)GPEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNEEGSEEKGPEVR 14 1 P31947-2;P31947 P31947-2 SFN 14-3-3 protein sigma 1 5480820.0 2412400.0 2077900.0 990520.0 True False 2335819.6824809974 2907616.3061053525 731073.0970369542 1.0 1.2447948477842345 0.3129835331554544 21.155497476576656 -6.836887355399645 1.2967865918768173 1.1303221474467782 0.28417872829555646 0.9189664757044281 0.11228050492142785 0.17246579794613298 0.5647246225502279 0.06792609964928205 0.15638107004849183 1.4558366374638766e-07 6.836887355399645 -0.8461434191512217 down SNEEGSEEK(ub)GPEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNEEGSEEKGPEVR 14 1 P31947-2;P31947 P31947-2 SFN 14-3-3 protein sigma 1 5146660.0 2412400.0 2350400.0 383860.0 True False 2006017.4874405202 2337737.92868213 464123.35123189224 1.0 1.1653626866757039 0.2313655559523899 20.935902752010932 -6.861167501284458 1.1799127956652937 1.090002310587877 0.1851371830173654 0.955038928051943 0.0862903523529515 0.1455983797570413 0.38452327704559297 0.05701525113359158 0.1332622311067381 1.3766784009562252e-07 6.861167501284458 -0.9048651275705117 down SNEILTAIIQGMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNEILTAIIQGMR 13 0 Q14974;Q14974-2;J3KTM9;J3QRG4 Q14974 KPNB1 Importin subunit beta-1 0 13096100.0 4550700.0 4215400.0 4330000.0 False True 5966011.769041481 3586478.751500507 3881973.136292882 1.0 0.6011518063224877 0.6506814412329884 22.50833539297803 -10.636386673537412 6.853045344270762 1.0012053406271335 0.625916623777738 0.9870227728360199 0.02022038877951121 0.0003734432293905505 1.981440153761434e-05 0.019634279400453578 0.006526102416407189 2.3100071623810018e-11 10.636386673537412 -0.37528871684939547 SNEILTAIIQGMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNEILTAIIQGMR 13 0 Q14974;Q14974-2;J3KTM9;J3QRG4 Q14974 KPNB1 Importin subunit beta-1 0 26326100.0 3914500.0 15925000.0 6486600.0 False True 5938582.688283401 13083059.327407077 5204520.666822222 1.0 2.2030609009148696 0.8763910414332606 22.501687225507283 -6.667912697048424 1.9445101259209772 1.7692620263731003 0.8817656575165939 0.269976129907628 0.5112771470471311 0.4659077052514849 3.394188455291305 0.21181523320461312 0.5675161667927175 2.148262279727914e-07 6.667912697048424 -0.8874963688565064 SNEILTAIIQGMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNEILTAIIQGMR 13 0 Q14974;Q14974-2;J3KTM9;J3QRG4 Q14974 KPNB1 Importin subunit beta-1 0 25333900.0 4550700.0 6564200.0 14219000.0 False True 6233216.768043421 6274171.939093403 10860765.049497264 1.0 1.0065704711666617 1.7424013079696583 22.57154545450092 -6.908855581551551 0.9034960213034675 0.9763841891279538 1.835202494014811 0.9904823432758777 0.03399259120157385 0.1051797743251009 0.14290970789395654 0.02767362117391419 0.07579906199524968 1.2335149528758124e-07 6.908855581551551 0.8588183048868573 SNEILTAIIQGMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNEILTAIIQGMR 13 0 Q14974;Q14974-2;J3KTM9;J3QRG4 Q14974 KPNB1 Importin subunit beta-1 0 18878200.0 9017900.0 5269400.0 4590900.0 False True 7498783.410707122 5241012.696305998 5550835.964076727 1.0 0.6989150651854578 0.7402315362450631 22.838225123638086 -10.887675511015226 11.134758090779634 1.0157439371611021 0.7195733007152606 0.9839802615552117 0.01686737867808355 0.005987865985118181 6.0403903668620827e-05 0.01483410822946162 0.005443923059532637 1.2951631786780413e-11 10.887675511015226 -0.2961706364458415 SNEILTAIIQGMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNEILTAIIQGMR 13 0 Q14974;Q14974-2;J3KTM9;J3QRG4 Q14974 KPNB1 Importin subunit beta-1 0 14634300.0 3914500.0 5535800.0 5184000.0 False True 5067397.416330892 5227727.863640708 4240565.192331842 1.0 1.0316396039499711 0.8368329625510748 22.272813547599732 -6.865249992573632 1.1588436190502391 1.017472664736314 0.8264045244145226 0.9597128364380382 0.017132805415862363 0.14149527776889734 0.35812404159205014 0.011503416330539314 0.027033379202021104 1.3637978687591886e-07 6.865249992573632 -0.1910681403217913 SNELK(ub)SHILELEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNELKSHILELEEK 14 1 O00635 O00635 TRIM38 E3 ubiquitin-protein ligase TRIM38 1 18913400.0 3911700.0 4459700.0 10542000.0 True False 3787525.2246563253 6240481.467028265 7780733.9467790285 1.0 1.6476408992350717 2.054305512245147 21.852824066191058 -8.782854048056697 0.1297919203037295 2.0749097746953653e-17 2.942473053026049 0.9999209083554025 0.003861041671011929 0.3167369050238638 0.03802519857973419 0.45915346363455956 0.3422702269060654 1.6487163772179994e-09 8.782854048056697 2.942473053026049 SNELK(ub)SHILELEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNELKSHILELEEK 14 1 O00635 O00635 TRIM38 E3 ubiquitin-protein ligase TRIM38 1 41621800.0 2802400.0 7210400.0 31609000.0 True False 4251445.682882971 5923647.78488767 25361467.29528317 1.0 1.3933255242416156 5.965374883511428 22.019522075250585 -6.923857399382588 0.7955872893745951 0.9124441101849458 6.772318692434069 0.9951872141193767 0.15635012950402713 0.09595499093777815 0.09423819507201507 0.13754091412890188 0.42850918548209826 1.1916332166304743e-07 6.923857399382588 5.859874582249123 up SNELK(ub)SHILELEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNELKSHILELEEK 14 1 O00635 O00635 TRIM38 E3 ubiquitin-protein ligase TRIM38 1 9481300.0 2733800.0 2953800.0 3793700.0 True False 3744559.7381671183 2823291.349089621 2897706.193704044 1.0 0.7539715070673599 0.77384429581097 21.836364674950577 -10.661795526471618 6.597493792010746 1.0013860520451094 0.763907901439165 0.9947141539815697 0.008113032031328321 0.0001663005087532644 8.524975608456498e-06 0.007898031207342544 0.0026184698287151625 2.1787353180594737e-11 10.661795526471618 -0.23747815060594446 SNELK(ub)SHILELEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNELKSHILELEEK 14 1 O00635 O00635 TRIM38 E3 ubiquitin-protein ligase TRIM38 1 12452000.0 3911700.0 5142900.0 3397400.0 True False 3252751.8676923746 5115194.176914279 4107780.632197235 1.0 1.5725743570299422 1.2628631999253759 21.633229341625334 -10.180684020274573 4.8721719621776 0.9999574367031991 1.4177187784788314 0.7080678894977105 0.1264390504295716 5.8463529935107494e-05 9.831395335853944e-06 0.12243652926242586 0.040808028051424174 6.596536650426577e-11 10.180684020274573 0.4177613417756323 SNELK(ub)SHILELEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNELKSHILELEEK 14 1 O00635 O00635 TRIM38 E3 ubiquitin-protein ligase TRIM38 1 42075500.0 2802400.0 4725100.0 34548000.0 True False 3627762.04356257 4462144.031303285 28260618.49241517 1.0 1.229999095233194 7.790097077222409 21.790648397343034 -6.914336735221804 0.8656852188271205 0.8236724828588255 8.721474887260694 0.9924577236764045 0.2733983228017511 0.10161945285761952 0.12372998512150904 0.22875010425790526 0.6521365108852007 1.218044807643234e-07 6.914336735221804 7.897802404401869 up SNFAEALAAHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNFAEALAAHK 11 0 P07237;H7BZ94;I3L312;I3NI03;I3L3U6;I3L0S0;I3L514;I3L3P5;I3L1Y5 P07237 P4HB Protein disulfide-isomerase 0 38701300.0 5834300.0 15292000.0 17575000.0 False True 7648823.799441564 13010493.207749138 15756507.591304256 1.0 1.7009795948886972 2.0599909220623736 22.866806483250162 -9.840252629057648 0.1615276916011932 2.8353554199815695e-25 2.5431998751068834 0.999682859666411 0.007838951337250814 1.351514517365968 0.07171849439937202 0.875800607997717 0.2821042316895671 1.4445992030754197e-10 9.840252629057648 2.5431998751068834 SNFAEALAAHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNFAEALAAHK 11 0 P07237;H7BZ94;I3L312;I3NI03;I3L3U6;I3L0S0;I3L514;I3L3P5;I3L1Y5 P07237 P4HB Protein disulfide-isomerase 0 32985400.0 10646000.0 6465400.0 15874000.0 False True 10308048.557325771 9047067.936615594 11716123.190207783 1.0 0.8776702870870726 1.1365995343397286 23.297267902529477 -6.77824133893152 1.542803123972336 0.9305754553140418 1.138535754505721 0.7610897009687783 0.05169429857148708 0.2533171582213532 1.1908445874615294 0.026394373560618127 0.062369736809079625 1.6663209749434734e-07 6.77824133893152 0.20796029919167924 SNFAEALAAHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNFAEALAAHK 11 0 P07237;H7BZ94;I3L312;I3NI03;I3L3U6;I3L0S0;I3L514;I3L3P5;I3L1Y5 P07237 P4HB Protein disulfide-isomerase 0 69134100.0 8426100.0 53589000.0 7119000.0 False True 12783009.730423989 44025624.25723198 5711926.529631454 1.0 3.4440734369817094 0.44683737633687926 23.607724219741005 -6.689881785454689 1.8667492302037165 2.5324336561747476 0.4571807225768438 0.3699303910698417 1.033693183813616 0.41691096594737065 2.8166731722599896 0.44299132451667855 1.153788947464733 2.0422937794434445e-07 6.689881785454689 -2.0752529335979037 SNFAEALAAHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNFAEALAAHK 11 0 P07237;H7BZ94;I3L312;I3NI03;I3L3U6;I3L0S0;I3L514;I3L3P5;I3L1Y5 P07237 P4HB Protein disulfide-isomerase 0 45298300.0 5834300.0 23353000.0 16111000.0 False True 7991398.376029125 22321187.241956074 12305913.616460409 1.0 2.793151610225109 1.539894901669905 22.930016544773054 -10.497187051970593 5.180686126842185 0.9971028076031749 2.166523255947523 0.5359992292483258 0.5116399087800849 0.017142923517605758 0.0016638087263066265 0.4960256921346601 0.16513107049668815 3.182826373349153e-11 10.497187051970593 1.169420448344348 SNFAEALAAHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNFAEALAAHK 11 0 P07237;H7BZ94;I3L312;I3NI03;I3L3U6;I3L0S0;I3L514;I3L3P5;I3L1Y5 P07237 P4HB Protein disulfide-isomerase 0 18542500.0 10646000.0 4754100.0 3142400.0 False True 8852620.697766446 4728488.719685034 3799461.3111840175 1.0 0.534134340679258 0.4291905686349623 23.077673177963753 -13.999999999999998 0.209429006780337 3.687963774192781 0.36703551672849977 0.999489698843044 0.005603955772543982 12.733396318029673 0.14505493596082372 14.079865113954625 0.062413153427446674 1.0000000000000041e-14 13.999999999999998 -3.3209282574642813 SNFAEALAAHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNFAEALAAHK 11 0 P07237;H7BZ94;I3L312;I3NI03;I3L3U6;I3L0S0;I3L514;I3L3P5;I3L1Y5 P07237 P4HB Protein disulfide-isomerase 0 24087600.0 8426100.0 8204600.0 7456900.0 False True 10907752.553262403 7748006.797576962 6099820.714255259 1.0 0.7103211004965095 0.5592188385709999 23.378850541833454 -13.999999999493514 0.0822709312308195 2.5414189204592956 0.1263563089199627 0.9998771322773751 0.002027232276524787 12.236155927976 0.0813562772406465 3.3980700016044185 0.3920358710066255 1.0000000011662261e-14 13.999999999493514 -2.4150626115393328 SNFGYNIPLK(ub)HLADR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNFGYNIPLKHLADR 15 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 28241700.0 9150900.0 12969000.0 6121800.0 True False 11996918.51744165 11034075.75276606 5488374.8604521435 1.0 0.9197424936015222 0.4574820486171429 23.51616055250353 -6.936705862899999 0.6895263377825651 1.0056012306189706 0.34404372417075335 0.9976998443046643 0.01146646676375897 0.08930205697272012 0.061696835278272286 0.010900627253767668 0.04039690814259604 1.1568955141378282e-07 6.936705862899999 -0.6615575064482172 down SNFGYNIPLK(ub)HLADR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNFGYNIPLKHLADR 15 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 32490500.0 10327000.0 12169000.0 9994500.0 True False 9999175.037713995 17028145.160496682 7376640.621426962 1.0 1.7029550034149263 0.7377249216664783 23.25337764240215 -6.711448322890451 1.790377502133746 1.431525950647572 0.7399267532428271 0.47185301901582155 0.2961550074638832 0.3721579508868915 2.3263797921492793 0.13160157675725334 0.3337020634517149 1.9433529194658676e-07 6.711448322890451 -0.6915991974047448 SNFGYNIPLK(ub)HLADR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNFGYNIPLKHLADR 15 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 110771000.0 36577000.0 32907000.0 41287000.0 True False 55489983.13688632 27034488.746435475 33126606.353265077 1.0 0.48719583640429354 0.5969835361374358 25.72572402877322 -9.981149316220634 5.967265055854867 1.0000003810906803 0.5420896862708596 0.9586689486972145 0.04482064073029685 2.2724883058770118e-07 3.874228630179165e-08 0.04339743466764132 0.01446579959285757 1.044361092250563e-10 9.981149316220634 -0.4579106948198207 SNFGYNIPLK(ub)HLADR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNFGYNIPLKHLADR 15 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 27863900.0 9150900.0 9729800.0 8983200.0 True False 12534235.02377405 9299905.263854079 6861553.17481144 1.0 0.7419603387214837 0.5474249654483845 23.57937061402642 -7.157710861112866 0.12879025447106454 1.3199725377719138 2.001494876326587e-10 0.999998674435461 0.00021334227423438663 0.08480492773022419 0.005085208250378183 0.017244947396075266 0.033387958373116915 6.954871958355175e-08 7.157710861112866 -1.3199725375717644 SNFGYNIPLK(ub)HLADR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNFGYNIPLKHLADR 15 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 34096800.0 10327000.0 15285000.0 8484800.0 True False 8587358.063670302 15202656.67116504 10258932.450717324 1.0 1.770353181787241 1.1946552565589164 23.033782917836426 -10.418277326151221 5.303934433519757 0.99960364695991 1.482504219173087 0.4836296598225732 0.23502769379808577 0.0011024207181913003 0.00012091107171455271 0.22774612918887824 0.07585486199812258 3.817004516650154e-11 10.418277326151221 0.48290057221317706 SNFGYNIPLK(ub)HLADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNFGYNIPLKHLADR 15 1 P25788-2;P25788;G3V4X5 P25788-2 PSMA3 Proteasome subunit alpha type-3 1 110204000.0 36577000.0 30895000.0 42732000.0 True False 47349647.54046102 29175666.0911123 34955214.46734649 1.0 0.6161749370189342 0.7382360013868469 25.49685035086567 -10.776875630767012 10.318136252386186 1.0016095279574155 0.6772054692028908 0.9031452667646871 0.049831220860399886 0.0018515237065501683 4.0038148877104165e-05 0.04841868335180492 0.01608295737612604 1.671569234297827e-11 10.776875630767012 -0.3244040587545247 SNFLNCYVSGFHPSDIEVDLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNFLNCYVSGFHPSDIEVDLLK 22 0 P61769 P61769 B2M Beta-2-microglobulin;Beta-2-microglobulin form pI 5.3 0 58934000.0 46691000.0 3972600.0 8270400.0 False True 45208819.76236124 5558879.896835323 6104134.133318281 1.0 0.12296007562363723 0.13502086905618135 25.43010091884666 -10.02816537976169 5.007615706583831 1.0000116212971553 0.12899047233334207 0.9998562177206329 0.004923798326945328 5442007.964399161 2724516.533424784 670.9052207838014 0.0016855476013410708 9.372050503695196e-11 10.02816537976169 -0.8710211489638132 SNFLNCYVSGFHPSDIEVDLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNFLNCYVSGFHPSDIEVDLLK 22 0 P61769 P61769 B2M Beta-2-microglobulin;Beta-2-microglobulin form pI 5.3 0 248418000.0 66736000.0 137800000.0 43882000.0 False True 101243391.05512336 113208513.36368589 35208703.465836175 1.0 1.1181817616326972 0.347762980861302 26.59325249422511 -6.867768096423411 1.1458985759424962 1.0660114212202252 0.304528411479751 0.962401165368893 0.0656901665447633 0.13900952655514542 0.3425542583720483 0.04454896672320376 0.10507711650972654 1.3559132465399967e-07 6.867768096423411 -0.7614830097404741 down SNFLNCYVSGFHPSDIEVDLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNFLNCYVSGFHPSDIEVDLLK 22 0 P61769 P61769 B2M Beta-2-microglobulin;Beta-2-microglobulin form pI 5.3 0 72618700.0 46691000.0 4471700.0 21456000.0 False True 38825635.26201515 4447610.0645370465 25942350.39866478 1.0 0.11455343961592154 0.6681758127997802 25.210506194280935 -10.038882529980524 6.368683746866293 1.0000004605787134 0.39136462649706333 0.6170758813634665 0.2260153874148828 1.4779863781004511e-06 2.2324472752352415e-07 0.2188386208983036 0.07294615262036781 9.143605285726867e-11 10.038882529980524 -0.60863583408165 SNFLNCYVSGFHPSDIEVDLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNFLNCYVSGFHPSDIEVDLLK 22 0 P61769 P61769 B2M Beta-2-microglobulin;Beta-2-microglobulin form pI 5.3 0 134247000.0 66736000.0 45488000.0 22023000.0 False True 86391067.56322847 42956552.812834404 18015039.975062523 1.0 0.4972337305751555 0.20852896582019378 26.364378816317558 -8.70112859142399 0.250034694013469 1.26535870481266 2.654309868262135e-14 0.9992645660217819 0.008868748098297187 0.26566267707185276 0.0734091613682408 0.1715243347663302 0.11248026691894135 1.9900840024048943e-09 8.70112859142399 -1.2653587048126334 SNFLVLCYLHDVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNFLVLCYLHDVK 13 0 P48147;A0A499FJL1 P48147 PREP Prolyl endopeptidase 0 1821710.0 660550.0 528250.0 632910.0 False True 865987.4467752996 449437.15910237253 567422.5445014152 1.0 0.5189880763005903 0.6552318357666056 19.72398658644853 -10.515968267750306 9.384824583575922 1.0000118380865488 0.5871099560336087 0.9245023066101781 0.0556212818883705 1.3777236345935124e-05 7.105492997235332e-07 0.053856615122832456 0.017951691537363937 3.048117695884506e-11 10.515968267750306 -0.4129018820529401 SNFLVLCYLHDVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNFLVLCYLHDVK 13 0 P48147;A0A499FJL1 P48147 PREP Prolyl endopeptidase 0 2946660.0 660550.0 847810.0 1438300.0 False True 904773.1856925499 810350.9508672454 1098603.1627183289 1.0 0.8956398837648688 1.2142304613917285 19.78719664797142 -6.818475143016684 1.3785502709019277 0.943662980350534 1.2209557381605953 0.8808217395099897 0.04578234959542385 0.19546976405194047 0.7303439974567748 0.02610101326675671 0.060181802308262956 1.5188848734046345e-07 6.818475143016684 0.27729275781006135 SNFSLAILNVGAPAAGMNAAVR ddPTM_RPMI8226_Bortezomib_1h_R1 2 SNFSLAILNVGAPAAGMNAAVR 22 0 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 0 6420000.0 1230900.0 3787700.0 1401400.0 False True 1613721.820052555 3222589.9243389624 1256396.5711780246 1.0 1.996992222757458 0.7785707273494678 20.621960471719287 -6.6892084999353045 1.8690380304487277 1.6255250423187513 0.7828068072181182 0.3667087338368159 0.4217281110826355 0.4184290760358304 2.833310456709586 0.18054121042304216 0.47064444839428426 2.0454623972868876e-07 6.6892084999353045 -0.842718235100633 SNFSLAILNVGAPAAGMNAAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNFSLAILNVGAPAAGMNAAVR 22 0 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 0 21901900.0 11118000.0 4030900.0 6753000.0 False True 10765065.1756855 5640459.390865803 4984186.7143425215 1.0 0.5239596136961269 0.46299642714658595 23.35985371835241 -13.999999999999998 0.2897621747546307 5.096535628506694 0.44634391245102395 0.9996269298347868 0.004636960346167192 15.951509130399762 0.17069775301592494 38.94728293237289 0.023048859547368964 1.0000000000000041e-14 13.999999999999998 -4.65019171605567 SNFSLAILNVGAPAAGMNAAVR ddPTM_RPMI8226_Bortezomib_8h_R1 2 SNFSLAILNVGAPAAGMNAAVR 22 0 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 0 135986800.0 34132000.0 59821700.0 42033100.0 False True 51780739.38344331 49146050.24592456 33725239.361237794 1.0 0.9491183561901555 0.6513085707698741 25.6259122300137 -6.936362152817292 0.692579199215108 1.0036444565861136 0.578921994751333 0.9976475332236626 0.007459209821105243 0.08946617371307014 0.06246514128000821 0.007074522100022092 0.026069060413298355 1.1578114687724879e-07 6.936362152817292 -0.4247224618347806 SNFSLAILNVGAPAAGMNAAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SNFSLAILNVGAPAAGMNAAVR 22 0 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 0 16243300.0 1230900.0 5803600.0 9208800.0 False True 1685996.9938217525 5547177.76206125 7033871.101189282 1.0 3.290146887799084 4.171935731181333 20.68517053324218 -9.288235701388665 0.31340377392880653 8.707240623378791e-14 4.497789084755522 0.9985546295564304 0.05082280341007541 0.6865361798670802 0.11958494037982621 1.0611040016126903 0.2909022510972038 5.149490942676537e-10 9.288235701388665 4.497789084755435 SNFSLAILNVGAPAAGMNAAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNFSLAILNVGAPAAGMNAAVR 22 0 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 0 19677800.0 11118000.0 3126600.0 5433200.0 False True 9245109.610911824 3109756.3852184936 6569256.999721553 1.0 0.3363677139693518 0.7105656153571166 23.140258993786688 -10.722749659082211 6.9658136179667896 1.0055823760164868 0.52346666466355 0.68377778673655 0.15276565353672017 0.013292491905882583 0.0005290616352535124 0.148456508573499 0.04930490266835076 1.893434739119534e-11 10.722749659082211 -0.48211571135293685 SNFSLAILNVGAPAAGMNAAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNFSLAILNVGAPAAGMNAAVR 22 0 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 0 61952000.0 24128000.0 23230000.0 14594000.0 False True 31234171.633984346 21937230.079188865 11938041.747085413 1.0 0.7023471067604705 0.3822109286899168 24.896621932697 -7.025393441035836 0.2600184402010419 1.0925749464988925 2.7845041297619623e-10 0.9999829877373136 0.0010404825402476445 0.07242901465268323 0.009068204389560673 0.006843262039548094 0.029113027496765916 9.432060091180813e-08 7.025393441035836 -1.0925749462204422 down SNFSNSADDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNFSNSADDIK 11 0 P45973 P45973 CBX5 Chromobox protein homolog 5 0 4636520.0 1777800.0 732220.0 2126500.0 False True 1721364.7121185202 1024599.2644768568 1569505.8563674462 1.0 0.5952249731062865 0.9117799646513155 20.715121368399068 -9.832544783678065 6.195855138169435 1.0000000144022112 0.7535024688786764 0.4470473330690401 0.12923303413650586 2.5600424401182664e-08 4.8150195582750735e-09 0.12512935284115173 0.041709782415813086 1.470466775655807e-10 9.832544783678065 -0.24649754552353476 SNFSNSADDIK(ub)SK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNFSNSADDIKSK 13 1 P45973 P45973 CBX5 Chromobox protein homolog 5 1 9423600.0 3825200.0 4095600.0 1502800.0 True False 5014874.243289497 3484552.4445237597 1347304.6718755078 1.0 0.6948434348451527 0.2686617064582154 22.257782092523065 -7.174617522695379 0.3747381052106038 1.0362303208547157 1.3229605719396666e-17 0.9998021444930352 0.004218806073572816 0.08526975171793379 0.021263137239556064 0.008148858604783437 0.0409801675609138 6.689327783237375e-08 7.174617522695379 -1.0362303208547157 down SNFSNSADDIK(ub)SK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNFSNSADDIKSK 13 1 P45973 P45973 CBX5 Chromobox protein homolog 5 1 20701200.0 7702900.0 7605700.0 5392600.0 True False 7458375.655854289 10642695.673201526 3980116.285467712 1.0 1.4269455125725363 0.5336438480868964 22.83043003245738 -6.77676118452363 1.5486390643220285 1.2427702474630873 0.5272933110550123 0.755686510926994 0.18031716880702267 0.25565352321596535 1.2108269228293116 0.09173167411859869 0.21702816950961676 1.6720097879685296e-07 6.77676118452363 -0.715476936408075 SNFSNSADDIK(ub)SK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNFSNSADDIKSK 13 1 P45973 P45973 CBX5 Chromobox protein homolog 5 1 10095000.0 3825200.0 4249300.0 2020500.0 True False 5239479.812143127 4061551.8754440094 1543299.513503706 1.0 0.7751822740171405 0.2945520488363984 22.320992154045957 -6.958720525267856 0.45310836517626546 1.0150162650214918 0.035565303634287934 0.9997197539910202 0.004925769622774613 0.080161419826189 0.022844532280966542 0.0064545948594509316 0.039738445350196605 1.0997132930671103e-07 6.958720525267856 -0.9794509613872039 down SNFSNSADDIK(ub)SK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNFSNSADDIKSK 13 1 P45973 P45973 CBX5 Chromobox protein homolog 5 1 22558500.0 7702900.0 13351000.0 1504600.0 True False 6405302.646329628 13279075.513033992 1819204.9035156188 1.0 2.0731378743896167 0.2840154484438079 22.610835307891655 -6.744248455475424 1.6709529901068176 1.635339137822919 0.28192195144166493 0.6239527015234381 0.4508697793631685 0.31017587222942 1.7019676682696343 0.21331741265925602 0.521078925472082 1.8019865476631259e-07 6.744248455475424 -1.353417186381254 SNFVHLFVSTLHFPHEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNFVHLFVSTLHFPHEQK 18 0 O14657;H0Y7C8 O14657 TOR1B Torsin-1B 0 18171000.0 4638300.0 6108800.0 7423900.0 False True 4491059.70537706 8548075.69697116 5479357.877773941 1.0 1.9033538313322158 1.2200590144044645 22.098624471151933 -10.203973731827336 4.71026693524213 0.9999027247638566 1.5617064228680706 0.4739705295906177 0.2789539409075492 0.0002929998799350347 4.951654858547885e-05 0.27014375362774135 0.09003199728913595 6.252105073037934e-11 10.203973731827336 0.561803698104214 SNFVHLFVSTLHFPHEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNFVHLFVSTLHFPHEQK 18 0 O14657;H0Y7C8 O14657 TOR1B Torsin-1B 0 45467700.0 8960700.0 22917000.0 13590000.0 False True 13594037.014919147 18827282.29866175 10903930.543291392 1.0 1.3849662376231016 0.8021112883041716 23.696470620428393 -6.728608359173448 1.7285619858355457 1.232030796026241 0.8025611388321069 0.5527142553160695 0.1618486434631548 0.3388398945892658 1.9828464135392856 0.07422351171528578 0.18445337544930576 1.8680635256401316e-07 6.728608359173448 -0.4294696571941342 SNFVHLFVSTLHFPHEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNFVHLFVSTLHFPHEQK 18 0 O14657;H0Y7C8 O14657 TOR1B Torsin-1B 0 10856300.0 4638300.0 2659400.0 3558600.0 False True 3856951.9615301667 2645073.2843504297 4302686.806892644 1.0 0.6857936813143638 1.115566605394183 21.87902974658621 -6.710719079813658 1.7924850188419525 0.8069702713059312 1.1145829344293134 0.46848457411929345 0.13239098081773884 0.3736862879320808 2.3408813071274324 0.058764068994975126 0.14916705033466182 1.9466188305230934e-07 6.710719079813658 0.3076126631233822 SNFVHLFVSTLHFPHEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNFVHLFVSTLHFPHEQK 18 0 O14657;H0Y7C8 O14657 TOR1B Torsin-1B 0 31855200.0 8960700.0 14177000.0 8717500.0 False True 11599802.791803848 13388037.487415424 7131004.449103553 1.0 1.154160784257048 0.6147522140757561 23.467596942520842 -6.830306311820348 1.326434491039638 1.0823589899756374 0.6001357793982739 0.9064986524888904 0.06936577382980921 0.18043905688414047 0.6207637763010522 0.04105722485275707 0.09448869184791439 1.4780655274764624e-07 6.830306311820348 -0.4822232105773635 SNGWILPTVYQGMYNATTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNGWILPTVYQGMYNATTR 19 0 O43488 O43488 AKR7A2 Aflatoxin B1 aldehyde reductase member 2 0 2271680.0 550530.0 894680.0 826470.0 False True 721750.1613401031 761197.2314353248 740954.8124600414 1.0 1.0546547437162725 1.0266084472835866 19.4611399993983 -10.151475028203922 4.157712502638375 0.9999879512783215 1.0406315955055676 0.7367337316000757 0.011449852591310391 8010706.762243906 0.018202701110374392 924.0191575108803 0.003919589087474279 7.055454115235268e-11 10.151475028203922 0.04064364422724609 SNGWILPTVYQGMYNATTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNGWILPTVYQGMYNATTR 19 0 O43488 O43488 AKR7A2 Aflatoxin B1 aldehyde reductase member 2 0 14409500.0 7547500.0 2986800.0 3875200.0 False True 7307908.743792632 4179444.8159562354 2860168.8664919487 1.0 0.571907088947474 0.3913799373755711 22.80102718800498 -13.999999999991065 0.1181870182011556 3.043400998549661 0.09608122906474142 0.9997018823945752 0.004406783873629079 11.971077181866772 0.10556423228012493 5.759770545832035 0.2620270184454643 1.0000000000205738e-14 13.999999999991065 -2.9473197694849196 SNGWILPTVYQGMYNATTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNGWILPTVYQGMYNATTR 19 0 O43488 O43488 AKR7A2 Aflatoxin B1 aldehyde reductase member 2 0 4701500.0 0.0 0.0 4701500.0 False True 0.0 0.0 3772246.4642593493 0.0 SNGWILPTVYQGMYNATTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNGWILPTVYQGMYNATTR 19 0 O43488 O43488 AKR7A2 Aflatoxin B1 aldehyde reductase member 2 0 6328230.0 550530.0 1202900.0 4574800.0 False True 754075.8185138429 1149751.9005416427 3494326.4609635067 1.0 1.52471657665354 4.63391926272114 19.52435006092119 -6.936099581035584 0.6948985733608389 0.9616560881068121 5.384184363940685 0.9976071432109074 0.07844988570205388 0.08959185151020152 0.0630547886597749 0.07427240202117433 0.2725163710902741 1.158511686141825e-07 6.936099581035584 4.422528275833873 up SNGWILPTVYQGMYNATTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNGWILPTVYQGMYNATTR 19 0 O43488 O43488 AKR7A2 Aflatoxin B1 aldehyde reductase member 2 0 12355700.0 7547500.0 2165000.0 2643200.0 False True 6276080.660942357 2153336.715281145 3195880.8992240345 1.0 0.3431021415454244 0.509216033361842 22.581432463439256 -10.529381446883198 9.54138142175602 1.0000185541211954 0.42615908745515224 0.9408684758012348 0.06781571235635155 2.6766861548980664e-05 1.3202808915327633e-06 0.06566439346135065 0.02188742704727852 2.955415543688713e-11 10.529381446883198 -0.5738594666660433 SNGWILPTVYQGMYNATTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNGWILPTVYQGMYNATTR 19 0 O43488 O43488 AKR7A2 Aflatoxin B1 aldehyde reductase member 2 0 5640100.0 0.0 5640100.0 0.0 False True 0.0 5326223.4769536415 0.0 0.0 SNIHCNTIAPNAGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNIHCNTIAPNAGSR 15 0 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ET17;A0A2R8Y7L2;E7ER27;A0A2R8Y7W2 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 3277400.0 637800.0 1397300.0 1242300.0 False True 836161.9764639856 1188828.2866327392 1113758.7129830597 1.0 1.4217679350359018 1.3319891890958646 19.673422914357857 -10.04570575839292 4.733355700915131 0.9999906422656268 1.3768785620202981 0.9591770616891668 0.036652019602028116 25375823.887123957 0.9471558927255268 3169.4964557309345 0.012546961188334562 9.001072123317887e-11 10.04570575839292 0.3768879197546713 SNIHCNTIAPNAGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNIHCNTIAPNAGSR 15 0 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ET17;A0A2R8Y7L2;E7ER27;A0A2R8Y7W2 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 8656900.0 1527900.0 6051700.0 1077300.0 False True 2317936.004452214 4971726.852852085 864371.1828026358 1.0 2.144893924294095 0.3729055423197105 21.14440930506721 -6.732277374315763 1.715036095496995 1.687234838030378 0.3735330323302734 0.5697707884711514 0.4812043246617736 0.33197207753089897 1.913980583133368 0.22226128019649857 0.5500869170833137 1.852348191566294e-07 6.732277374315763 -1.3137018057001046 SNIHCNTIAPNAGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNIHCNTIAPNAGSR 15 0 P51659;A0A2R8YD50;P51659-3;P51659-2;E7ET17;A0A2R8Y7L2;E7ER27;A0A2R8Y7W2 P51659 HSD17B4 Peroxisomal multifunctional enzyme type 2;(3R)-hydroxyacyl-CoA dehydrogenase;Enoyl-CoA hydratase 2 0 2354400.0 637800.0 1716600.0 0.0 False True 873611.8958969162 1640754.9359629087 0.0 1.0 1.8781279692607498 0.0 19.73663297588075 -6.787697764615789 1.559092853089787 1.4970473816322345 4.026951086224946e-20 0.7655149089001695 0.37154527427119866 0.2457937879653493 1.1888185786963525 0.18919534587634754 0.43389915871517104 1.6304302913503954e-07 6.787697764615789 -1.4970473816322345 SNILTLMYQCMQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNILTLMYQCMQDK 14 0 Q92973-2;Q92973;Q92973-3 Q92973-2 TNPO1 Transportin-1 0 6526700.0 1793600.0 2938300.0 1794800.0 False True 2351426.969247107 2499917.0934036947 1609091.3129372916 1.0 1.0631489415144932 0.6843041837920654 21.165105094911024 -6.864056246789674 1.1649779496184305 1.0347100798042406 0.6644769815650504 0.9583880495007806 0.033805708036723635 0.14268676306798037 0.36568414642207 0.02259147455020562 0.05300349807475433 1.3675516983762708e-07 6.864056246789674 -0.37023309823919015 SNILTLMYQCMQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNILTLMYQCMQDK 14 0 Q92973-2;Q92973;Q92973-3 Q92973-2 TNPO1 Transportin-1 0 9127800.0 1793600.0 2932900.0 4401300.0 False True 2456742.3902174807 2803314.7801966774 3361803.587618837 1.0 1.141069894572266 1.3683989013277198 21.228315156433915 -6.96403907919864 0.3741846370797038 0.983326877498916 1.5341071161357858 0.9998919351255237 0.0015776641718911973 0.0782886606201555 0.01601954835201579 0.0029786647198767205 0.019264544788490434 1.086327867982611e-07 6.96403907919864 0.5507802386368698 SNLAYDIVQLPTGLTGIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNLAYDIVQLPTGLTGIK 18 0 P34932;A0A087WYC1;A0A087WTS8;P34932-2 P34932 HSPA4 Heat shock 70 kDa protein 4 0 8207800.0 2983500.0 3252400.0 1971900.0 False True 3911397.392255103 2767154.597755907 1767866.7038004475 1.0 0.7074593349259543 0.4519782897286204 21.89925268854786 -7.076340115831837 0.19052580352169252 1.1787976076234343 1.615615411454783e-14 0.99999536883479 0.0004818000635901892 0.07424066445810076 0.006516111735818703 0.010056045679709524 0.02851824570207307 8.388028244478032e-08 7.076340115831837 -1.1787976076234181 down SNLAYDIVQLPTGLTGIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNLAYDIVQLPTGLTGIK 18 0 P34932;A0A087WYC1;A0A087WTS8;P34932-2 P34932 HSPA4 Heat shock 70 kDa protein 4 0 27822300.0 11631000.0 7564100.0 8627200.0 False True 11261780.271487521 10584484.576260401 6367477.509547723 1.0 0.9398589140527016 0.5654059443575585 23.42493157207633 -6.935056946487169 0.7040488547365965 1.004769074372417 0.4775973298486807 0.9974420602636611 0.009724176091317743 0.09009589467509066 0.06543190266074626 0.009142720808300775 0.03299052886589294 1.1612963298827325e-07 6.935056946487169 -0.5271717445237363 SNLAYDIVQLPTGLTGIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNLAYDIVQLPTGLTGIK 18 0 P34932;A0A087WYC1;A0A087WTS8;P34932-2 P34932 HSPA4 Heat shock 70 kDa protein 4 0 16838800.0 2983500.0 2535300.0 11320000.0 False True 4086580.5760559 2423282.0628840546 8646449.142718118 1.0 0.5929852642775608 2.1158151617955134 21.962462750070753 -6.835576700363969 1.3026821750723434 0.78320323122542 2.1617021909247236 0.916596184468838 0.18591291037340335 0.17402724263912858 0.5755474894138756 0.11197973195506644 0.25776726914895004 1.4602368355325497e-07 6.835576700363969 1.3784989596993036 up SNLAYDIVQLPTGLTGIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNLAYDIVQLPTGLTGIK 18 0 P34932;A0A087WYC1;A0A087WTS8;P34932-2 P34932 HSPA4 Heat shock 70 kDa protein 4 0 20104900.0 11631000.0 3980400.0 4493500.0 False True 9671691.84066519 3958956.795152464 5433070.074403441 1.0 0.40933446395663686 0.5617497087282891 23.205336847510605 -10.406242017986541 9.027504021101368 1.0000022449014587 0.4855420863427355 0.938236659550713 0.062223263118658265 2.8114224647241336e-06 1.848732290353775e-07 0.06024767836281073 0.020082471817103802 3.9242618828716083e-11 10.406242017986541 -0.5144601585587232 SNLGSVVLQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNLGSVVLQLK 11 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 94712000.0 20215000.0 34438000.0 40059000.0 False True 26502060.76233845 29299984.638272613 35914078.95306162 1.0 1.1055738231462453 1.35514288021324 24.659601210152015 -6.956649772202292 0.4803304269633111 0.9940282267567997 1.4770994244065891 0.999625044564953 0.002883375457651308 0.08092036919351292 0.02572396676627995 0.0035212131704901173 0.020587086626265648 1.10496934036073e-07 6.956649772202292 0.48307119764978945 SNLGSVVLQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNLGSVVLQLK 11 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 103987000.0 27791000.0 21954000.0 54242000.0 False True 26908789.917024277 30720346.688597564 40034392.974880315 1.0 1.1416472752333557 1.4877812453971375 24.681574178937126 -6.955948439778909 0.4892022510185551 0.9923700714667963 1.6517162768484943 0.9995891788101042 0.004152767058766093 0.08118143970739243 0.02673019572294313 0.004975066631189003 0.028548138868244505 1.1067551721404888e-07 6.955948439778909 0.659346205381698 SNLGSVVLQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNLGSVVLQLK 11 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 329631000.0 66181000.0 144240000.0 119210000.0 False True 100401415.47918841 118499245.04773633 95648091.24840094 1.0 1.1802547253160918 0.9526568006227686 26.581204367933505 -6.695644008728418 1.8464726002166816 1.112406654936358 0.953388219468985 0.39688683489422927 0.07615026832641225 0.4046624288685355 2.6791488948702082 0.03294049607576259 0.08517057460882106 2.015375576727057e-07 6.695644008728418 -0.15901843546737304 SNLGSVVLQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNLGSVVLQLK 11 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 151237000.0 20215000.0 54648000.0 76374000.0 False True 27689031.78983404 52233470.66323031 58336034.17190409 1.0 1.886431821079699 2.106828242124451 24.722811271674907 -10.734246812475563 0.27973421813462046 4.5055493989997726e-23 2.189762968632542 0.9991568444880288 0.013890036939926142 2.458471887748163 0.14098084561142174 1.7435337738435273 0.08659795468686157 1.8439671823935632e-11 10.734246812475563 2.189762968632542 SNLGSVVLQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNLGSVVLQLK 11 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 74573000.0 27791000.0 21947000.0 24835000.0 False True 23109447.850049525 21828767.154861607 30027883.67593403 1.0 0.9445819431300184 1.2993769418800578 24.461979454371402 -6.866991812413797 1.1499624422452908 0.969164120775949 1.318995047349658 0.9615836640194741 0.030544930613215397 0.13976790779082415 0.3473447833314894 0.020650245910316816 0.048648270184749605 1.358339054587558e-07 6.866991812413797 0.34983092657370884 SNLGSVVLQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNLGSVVLQLK 11 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 263543000.0 66181000.0 122130000.0 75232000.0 False True 85672609.1225429 115333358.13910188 61540547.94550707 1.0 1.3462104086748816 0.7183223270051431 26.352330690025955 -6.757007339039969 1.6235948955341815 1.201845850826468 0.7163515009383983 0.6786660050628834 0.145562061659442 0.2879853892008745 1.4954673486025698 0.07075967705556255 0.17056244825103672 1.7498171186282263e-07 6.757007339039969 -0.4854943498880697 SNLK(ub)IAELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNLKIAELK 9 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 160100000.0 48140000.0 67944000.0 44016000.0 True False 63112006.18842318 57807020.04363766 39461646.55128585 1.0 0.9159433130845613 0.6252637007524634 25.91141114835482 -6.948219921198592 0.5780547559573661 1.0035005238418804 0.5233769439132289 0.9990540942473423 0.004937812954759963 0.08420848111690883 0.03898180933666054 0.005184490302262726 0.02426939175362215 1.1266268022271117e-07 6.948219921198592 -0.4801235799286515 SNLK(ub)IAELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNLKIAELK 9 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 255957000.0 92466000.0 58611000.0 104880000.0 True False 89530717.44332944 82014677.95232716 77408781.66744298 1.0 0.9160507175008429 0.86460584565784 26.415879411393263 SNLK(ub)IAELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNLKIAELK 9 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 424930000.0 105680000.0 190560000.0 128690000.0 True False 160324286.24288905 156553079.1479242 103254365.09316926 1.0 0.9764776305365769 0.64403445986181 27.256417743470074 -6.921170018321336 0.8160133944354679 1.0070304845404938 0.5889572783949493 0.9944995378705513 0.012055046659936345 0.09748831046528335 0.10208651861252623 0.010451499772229459 0.031665561802528365 1.1990298130846864e-07 6.921170018321336 -0.41807320614554455 SNLK(ub)IAELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNLKIAELK 9 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 188899000.0 48140000.0 65904000.0 74855000.0 True False 65938658.93458385 62992143.364615805 57175790.68711704 1.0 0.9553142933511704 0.8671057557273004 25.97462120987771 -6.9603015716287615 0.43118255497846164 1.0034601526394156 0.8155707499179687 0.9997811602492721 0.0008167905443474942 0.0795938447221293 0.02073636954306921 0.0011515442823400765 0.0073220295701752515 1.0957170721839639e-07 6.9603015716287615 -0.18788940272144683 SNLK(ub)IAELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNLKIAELK 9 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 237618000.0 92466000.0 93311000.0 51841000.0 True False 76889575.93834986 92808315.12221654 62680713.4142982 1.0 1.2070337752497209 0.8152043062970676 26.19628468682754 -6.763147384636064 1.6006595287969003 1.119784268123556 0.8135470500364147 0.7036863063742484 0.08712250512757563 0.2776528769084629 1.402725906079423 0.04293144021696729 0.10285144716562077 1.7252523012350056e-07 6.763147384636064 -0.3062372180871412 SNLK(ub)IAELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNLKIAELK 9 1 O43765 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 389177000.0 105680000.0 207180000.0 76317000.0 True False 136804843.26423505 195650250.874143 62428089.078547195 1.0 1.4301412596646856 0.45632952451814107 27.027544065562523 -6.786652347748355 1.5097931271021674 1.2414619409533159 0.44692519716459905 0.7902366947979425 0.1824927838346669 0.24039335082638766 1.0825831086571127 0.09516194300197964 0.22334221785240457 1.6343597275377458e-07 6.786652347748355 -0.7945367437887167 down SNLK(ub)IAEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNLKIAEQK 9 1 Q96EQ0 Q96EQ0 SGTB Small glutamine-rich tetratricopeptide repeat-containing protein beta 1 2850370.0 610970.0 355300.0 1884100.0 True False 800987.5866418972 302290.62494855287 1689151.4055633778 1.0 0.37739739040887277 2.1088359342060037 19.611420358982226 -6.809459209648168 1.4169371198666287 0.660476635268882 2.138717524809521 0.8583868050227482 0.26947463776624886 0.20753379122333865 0.8213396508940184 0.1495498268329488 0.34600382314534833 1.5507464311085886e-07 6.809459209648168 1.478240889540639 up SNLK(ub)IAEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNLKIAEQK 9 1 Q96EQ0 Q96EQ0 SGTB Small glutamine-rich tetratricopeptide repeat-containing protein beta 1 5573910.0 659310.0 1323500.0 3591100.0 True False 638380.5649380478 1851980.451961321 2650483.1793092573 1.0 2.901060204019601 4.1518857635750175 19.284057204796717 -8.269078338251294 0.23177170177922327 9.345277449365253e-17 5.350588998209485 0.9995764399196726 0.02666927908558324 0.09552829674566383 0.05316783116109894 0.466085594067101 0.48748359461611135 5.381726979057072e-09 8.269078338251294 5.350588998209485 SNLK(ub)IAEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNLKIAEQK 9 1 Q96EQ0 Q96EQ0 SGTB Small glutamine-rich tetratricopeptide repeat-containing protein beta 1 8281140.0 908340.0 2656500.0 4716300.0 True False 1378018.188549071 2182426.8196707647 3784121.237772273 1.0 1.5837431158790898 2.746060443336101 20.394163499714978 -6.960131493405827 0.433576171847969 0.9555445125874552 3.4190962399547464 0.9997750463787614 0.010885180513094632 0.07965417767384912 0.020957957111630406 0.01521125258221847 0.09643090959879179 1.096146260478202e-07 6.960131493405827 2.463551727367291 SNLK(ub)IAEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNLKIAEQK 9 1 Q96EQ0 Q96EQ0 SGTB Small glutamine-rich tetratricopeptide repeat-containing protein beta 1 3742670.0 610970.0 635200.0 2496500.0 True False 836862.11984343 607134.7636744967 1906878.1170314308 1.0 0.7254895989175452 2.2786048882080983 19.674630420505117 -6.861250792838792 1.1794761214543767 0.8505527043212899 2.3556037237510057 0.9551386339575403 0.14334666993492548 0.1455141241949794 0.3839664033574053 0.09474551680564326 0.2214734851234582 1.3764143987787086e-07 6.861250792838792 1.5050510194297158 up SNLK(ub)IAEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNLKIAEQK 9 1 Q96EQ0 Q96EQ0 SGTB Small glutamine-rich tetratricopeptide repeat-containing protein beta 1 4954110.0 659310.0 1598800.0 2696000.0 True False 548245.4773853464 1590186.9470630463 3259721.135104415 1.0 2.90050171439052 5.945732832399178 19.064462480230993 -6.964137273273751 0.3725620725934051 0.7725168550070455 8.180145742889525 0.9998942421503677 0.02094859151849356 0.07825495092919976 0.015899705159634955 0.03998895330775796 0.2582789039434478 1.0860822767848094e-07 6.964137273273751 7.40762888788248 SNLK(ub)IAEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNLKIAEQK 9 1 Q96EQ0 Q96EQ0 SGTB Small glutamine-rich tetratricopeptide repeat-containing protein beta 1 3413440.0 908340.0 2505100.0 0.0 True False 1175864.0360582443 2365688.982840122 0.0 1.0 2.0118728954160665 0.0 20.165289821807427 -6.775844124448293 1.5904485448206906 1.5801197441931192 7.491038802233828e-10 0.7301685184191269 0.4266519592476606 0.262327947834714 1.316479407301913 0.21267813008765996 0.4957998444508261 1.6755441489295694e-07 6.775844124448293 -1.5801197434440153 SNLLWDTGVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNLLWDTGVFR 11 0 Q96AK3;Q6ICH2;B0QYD3;Q9UH17-3;Q9UH17;Q9UH17-2 Q96AK3;B0QYD3 APOBEC3D;bK150C2.9;APOBEC3B DNA dC->dU-editing enzyme APOBEC-3D;DNA dC->dU-editing enzyme APOBEC-3B 0 11967900.0 2362300.0 2798600.0 6807000.0 False True 3096998.176545745 2381059.788857362 6102676.937354661 1.0 0.768828282460628 1.9705135713580937 21.562439102905305 -6.856870782866645 1.2015910854327412 0.8754866155757868 2.025278595347392 0.9497011462213404 0.11676103013505719 0.15006541223100975 0.41352717057750327 0.0758831676997398 0.17653937029435193 1.3903662501378167e-07 6.856870782866645 1.1497919797716052 SNLLWDTGVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNLLWDTGVFR 11 0 Q96AK3;Q6ICH2;B0QYD3;Q9UH17-3;Q9UH17;Q9UH17-2 Q96AK3;B0QYD3 APOBEC3D;bK150C2.9;APOBEC3B DNA dC->dU-editing enzyme APOBEC-3D;DNA dC->dU-editing enzyme APOBEC-3B 0 13557600.0 2362300.0 4528800.0 6666500.0 False True 3235706.1487571155 4328702.641261114 5092010.000877242 1.0 1.3377922599441965 1.5736935824142007 21.625649164428197 -6.974970355324096 0.07191423329015151 0.031685592262970325 2.885698182146515 0.9999999346695634 5.989980201566737e-05 0.07472072238531557 0.002077600061400159 0.032401235235088546 0.049777965522064135 1.0593260316569475e-07 6.974970355324096 2.8540125898835447 SNLLWDTGVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNLLWDTGVFR 11 0 Q96AK3;Q6ICH2;B0QYD3;Q9UH17-3;Q9UH17;Q9UH17-2 Q96AK3;B0QYD3 APOBEC3D;bK150C2.9;APOBEC3B DNA dC->dU-editing enzyme APOBEC-3D;DNA dC->dU-editing enzyme APOBEC-3B 0 8683600.0 4446000.0 2455000.0 1782600.0 False True 3697045.9911957197 2441774.4277206515 2155333.418188845 1.0 0.6604663381347115 0.5829879918512333 21.817941560065258 -13.999999999999988 0.20760443753610114 2.9445680935014895 0.5362792773396469 0.9994888062717502 0.004094663591177199 12.69163261855621 0.14443332359098837 10.055333902634631 0.04667676972901156 1.0000000000000286e-14 13.999999999999988 -2.4082888161618428 SNLVDNTNQVEVLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNLVDNTNQVEVLQR 15 0 Q9NUU7;I3L0H8;F6QDS0;Q9UMR2;H3BQK0;Q9UMR2-4;Q9UMR2-2;H3BTB3;H3BMQ5;H3BN59 Q9NUU7 DDX19A;DDX19B ATP-dependent RNA helicase DDX19A;ATP-dependent RNA helicase DDX19B 0 12765400.0 1652800.0 4327700.0 6784900.0 False True 2166836.8057379695 3682024.0292424727 6082863.633356485 1.0 1.699262270002133 2.807255081346477 21.047159070970658 -6.964330512107811 0.36936656268554197 0.9141803075605532 3.63086597343731 0.9998986667239493 0.00749015503741466 0.07818893540795457 0.015665804704160607 0.014618385453811484 0.09413320542022854 1.0855991332103694e-07 6.964330512107811 2.7166856658767564 SNLVDNTNQVEVLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNLVDNTNQVEVLQR 15 0 Q9NUU7;I3L0H8;F6QDS0;Q9UMR2;H3BQK0;Q9UMR2-4;Q9UMR2-2;H3BTB3;H3BMQ5;H3BN59 Q9NUU7 DDX19A;DDX19B ATP-dependent RNA helicase DDX19A;ATP-dependent RNA helicase DDX19B 0 10506800.0 1652800.0 3699700.0 5154300.0 False True 2263884.825240553 3536235.0207281727 3936960.4961406332 1.0 1.5620207270714066 1.7390286167593816 21.11036913249355 -11.314931888454284 0.21195732649093532 2.2022141404827213e-15 1.8591714340095522 0.9993444897183777 0.008066445796758734 3.6594283052033787 0.12136830008457841 1.8174987715396118 0.10220803483221519 4.842483075645746e-12 11.314931888454284 1.85917143400955 SNLYK(ub)FTASASHTER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNLYKFTASASHTER 15 1 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 5923800.0 1183000.0 1352500.0 3388300.0 True False 1145446.3125414613 1892560.3031943243 2500802.5831788476 1.0 1.6522470607943225 2.1832560424680114 20.12747840994378 -6.973469019466362 0.15423706873233844 0.41811364641349386 3.431406811765412 0.9999983542732276 0.0006207571896923788 0.075192267815005 0.004733819339869175 0.025987982666473234 0.06513114655937821 1.0629944096120842e-07 6.973469019466362 3.0132931653519184 SNLYK(ub)FTASASHTER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNLYKFTASASHTER 15 1 E9PH99;Q9Y4E5-2;Q9Y4E5 E9PH99 ZNF451 Zinc finger protein 451 1 5334900.0 1183000.0 2354700.0 1797200.0 True False 983716.915785996 2342014.763728645 2172986.2106860713 1.0 2.3807812249089575 2.2089548078471757 19.907883685378057 -10.120167569739879 4.670996900873792 0.9998994156025551 2.294868016397357 0.9869655674324149 0.07014784108805534 7.348349815426316e-05 1.384143545308976e-05 0.06792554818865741 0.02264011834952837 7.582849391975316e-11 10.120167569739879 1.2949686007948018 SNMHFTSSSTGGLSSSQSSYSPSNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNMHFTSSSTGGLSSSQSSYSPSNR 25 0 Q9P0J7;C9J3I2 Q9P0J7 KCMF1 E3 ubiquitin-protein ligase KCMF1 0 8387700.0 2206200.0 2360200.0 3821300.0 False True 2892349.564871191 2008067.359987544 3425908.532497921 1.0 0.6942685574303921 1.1844725043290165 21.46381049403005 -6.738048004716935 1.6937341699474249 0.8176812439438016 1.1846452522116084 0.596184093771668 0.12846278686613816 0.3213642839066761 1.8093877234551152 0.0600189536772844 0.14760407840925158 1.8278981583522134e-07 6.738048004716935 0.36696400826780684 SNMHFTSSSTGGLSSSQSSYSPSNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNMHFTSSSTGGLSSSQSSYSPSNR 25 0 Q9P0J7;C9J3I2 Q9P0J7 KCMF1 E3 ubiquitin-protein ligase KCMF1 0 4522200.0 2206200.0 1086200.0 1229800.0 False True 3021891.7603132282 1038208.0924169363 939346.5685260366 1.0 0.343562302942751 0.31084719210084166 21.52702055555294 -13.586949810373282 0.43121187474227934 9.999513671434253 0.3102035389542809 0.9998717422871946 0.0035950305218075043 21.97409000941139 0.2201774143080013 184.67842765257055 0.0077217737731575245 2.5885120415566452e-14 13.586949810373282 -9.68931013247997 SNNHENVSLAK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNNHENVSLAKAK 13 1 J3QR07;Q96MU7-2;Q96MU7 J3QR07 YTHDC1 YTH domain-containing protein 1 1 2642350.0 557470.0 892180.0 1192700.0 True False 763581.7240602907 852760.5375552764 911008.8244275539 1.0 1.1167901361242432 1.1930731128337255 19.54242304742078 SNNK(ub)YSYTSNSDDNMLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNNKYSYTSNSDDNMLK 17 1 Q9H3F6;F5H6V0;F5H497 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 10561800.0 3583700.0 3553600.0 3424500.0 True False 4698265.404600166 3023416.7318243105 3070165.5901235524 1.0 0.6435176541674343 0.6534678920261703 22.16369678269245 -9.98664919820763 4.924431470293946 1.000003076512594 0.6484927730883879 0.9993993802177036 0.0040621676302333275 5591771.478670929 2.6510316276654393 227.97253068157576 0.00139058802180853 1.031218752072054e-10 9.98664919820763 -0.3515103034242061 SNNK(ub)YSYTSNSDDNMLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNNKYSYTSNSDDNMLK 17 1 Q9H3F6;F5H6V0;F5H497 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 14015300.0 5000300.0 4259400.0 4755600.0 True False 4841568.213525839 5960200.632477564 3509965.6950580906 1.0 1.231047538652169 0.7249646272156892 22.207042990259147 -6.782561841580948 1.5256558811087584 1.13039222630326 0.7206133657857838 0.7763967684501377 0.09782080465897121 0.24663081762676636 1.133990362079527 0.05048911263521524 0.1188922370100177 1.6498260567828428e-07 6.782561841580948 -0.40977886051747614 SNNK(ub)YSYTSNSDDNMLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNNKYSYTSNSDDNMLK 17 1 Q9H3F6;F5H6V0;F5H497 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 40941800.0 8884800.0 8962000.0 23095000.0 True False 13478891.165885886 7362661.079574397 18530263.1271019 1.0 0.5462364069092543 1.3747616847000497 23.68419848304025 -6.758034022877186 1.6201480625736533 0.735777317973035 1.3774670137796567 0.6827543607142421 0.19080294792625974 0.2862477558339962 1.4804572628418722 0.09294595594437174 0.2237748457135375 1.7456853895753535e-07 6.758034022877186 0.6416896958066217 SNNK(ub)YSYTSNSDDNMLK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SNNKYSYTSNSDDNMLK 17 1 Q9H3F6;F5H6V0;F5H497 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 17678500.0 5704300.0 7629100.0 4345100.0 True False 4743378.193337323 7588000.524042211 5253640.320527515 1.0 1.5997038850287166 1.1075735702261567 22.177483469557007 -10.14980581501804 4.318869050070647 0.9999446980648766 1.3536387269880021 0.4077551347238293 0.2009113601095159 140541314.79098734 15.51940393928139 105207.91824218284 0.06877730243044958 7.08262397151582e-11 10.14980581501804 0.3536940289231255 SNNK(ub)YSYTSNSDDNMLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SNNKYSYTSNSDDNMLK 17 1 Q9H3F6;F5H6V0;F5H497 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 59300600.0 15079100.0 15567100.0 28654400.0 True False 19520192.203498535 14700777.20041931 23439593.2189725 1.0 0.7531061706341469 1.2007870094010398 24.218463922525707 -6.756988703745149 1.6236938104002299 0.8560511910648445 1.2021881968674324 0.6785470252070686 0.10380493789500614 0.28803266933429184 1.4958954547525196 0.05045812721583236 0.12162751038137251 1.7498922037579195e-07 6.756988703745149 0.3461370058025879 SNNTSK(ub)PSHSVDAHTAEVNCLSFNPYSEFILATGSADK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADK 38 1 Q09028-3;Q09028;Q09028-2;Q09028-4;H0YF10;H0YCT5;H0YDK2 Q09028-3;H0YDK2 RBBP4 Histone-binding protein RBBP4 1 96235200.0 67855000.0 6893200.0 21487000.0 True False 87839635.12201612 6509587.360390203 17576586.475238096 1.0 0.0741076320655007 0.20009858250006213 26.388368725740996 -10.557702558896379 6.217746162043848 1.0015341424538524 0.13710310728304373 0.9842625942037314 0.05143559012882705 0.001095280138772316 7.791238046703355e-05 0.04986666970671938 0.016600765330941472 2.768837327041394e-11 10.557702558896379 -0.8644310351708087 SNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNNTSKPSHSVDAHTAEVNCLSFNPYSEFILATGSADK 38 1 Q09028-3;Q09028;Q09028-2;Q09028-4;H0YF10;H0YCT5;H0YDK2 Q09028-3;H0YDK2 RBBP4 Histone-binding protein RBBP4 0 112562600.0 3995600.0 94430000.0 14137000.0 False True 6061617.317487578 77578228.71504256 11342815.753532784 1.0 12.798272251735817 1.8712523670554246 22.53127134398189 -6.628006020851107 2.0874769727011087 8.784265127908416 1.9147976479112923 0.11032649134839512 5.0634200809499905 0.5643147433144771 4.68334623782139 1.9855761481276553 5.610548051528774 2.3550166348447546e-07 6.628006020851107 -6.869467479997123 SNNVEMDWVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNNVEMDWVLK 11 0 P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;E5RGH4;H0YAQ2 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 12915200.0 3228800.0 4610000.0 5076400.0 False True 4232988.067743681 3922205.969639256 4551142.824267248 1.0 0.9265809179873068 1.0751607969197874 22.013244991211955 -6.772324439638329 1.565393550370955 0.95801472930792 1.076074384018489 0.7394473134838924 0.03096293302024253 0.2626776549503342 1.2706102142859876 0.015587348487473073 0.03702827160067724 1.6891785595431058e-07 6.772324439638329 0.118059654710569 SNNVEMDWVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNNVEMDWVLK 11 0 P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;E5RGH4;H0YAQ2 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 10607900.0 3228800.0 3839500.0 3539600.0 False True 4422574.615039144 3669858.194471395 2703619.3803502736 1.0 0.8298013066850006 0.6113225023172038 22.076455052734847 -6.967715985823287 0.3078952055717962 1.0345061163629556 0.3996939892604655 0.999958685266447 0.0010225235185821922 0.07705101472494807 0.011669320125107114 0.003490156669946079 0.019436727237720282 1.0771694163886464e-07 6.967715985823287 -0.6348121271024901 SNNVEMDWVLK(ub)HTGPNSPDTANDGFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNNVEMDWVLKHTGPNSPDTANDGFVR 27 1 P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;E5RGH4;H0YAQ2 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 21115000.0 5247000.0 5500000.0 10368000.0 True False 5080436.857062586 7696178.682121092 7652309.766667148 1.0 1.5148655319713746 1.5062306612529324 22.2765211262468 -10.069225126464135 4.890733631033147 0.9999856825826585 1.5105480966167306 0.9997855097147461 0.0035251712249909457 5.50343102080456e-07 1.0473911434961098e-07 0.00341332798649186 0.0011377441183225915 8.526580046870138e-11 10.069225126464135 0.5105624140340721 SNNVEMDWVLK(ub)HTGPNSPDTANDGFVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNNVEMDWVLKHTGPNSPDTANDGFVR 27 1 P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;E5RGH4;H0YAQ2 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 49495700.0 9354700.0 20022000.0 20119000.0 True False 14191763.820177473 16448917.667399999 16142470.831529042 1.0 1.1590467454097118 1.1374534579400275 23.758550569782347 -10.077367338116485 4.537163476056337 0.9999903426345962 1.1482501016815463 0.9843377864128424 0.008815422717722945 8.612210794073711e-07 1.7514290171298435e-07 0.008536052224303012 0.002845165444762818 8.368211765294383e-11 10.077367338116485 0.1482597590469501 SNNVEMDWVLK(ub)HTGPNSPDTANDGFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNNVEMDWVLKHTGPNSPDTANDGFVR 27 1 P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;E5RGH4;H0YAQ2 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 10941700.0 1852200.0 3155200.0 5934300.0 True False 2537008.3938229377 3015792.83114888 4532740.560744896 1.0 1.1887200840532015 1.7866478375795407 21.27469686196477 -6.950217278932933 0.5564534242661562 0.9920298615805615 2.011740552481604 0.9992182221308816 0.009375606695308262 0.08339862044280781 0.035602237592668264 0.01009371772783475 0.04966658605147848 1.1214572452419793e-07 6.950217278932933 1.0197106909010425 SNNVEMDWVLK(ub)HTGPNSPDTANDGFVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNNVEMDWVLKHTGPNSPDTANDGFVR 27 1 P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;E5RGH4;H0YAQ2 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 19443300.0 5247000.0 5595300.0 8601000.0 True False 4363112.981512353 5565157.008319906 10399429.333469244 1.0 1.2755014669344862 2.3834884353291645 22.056926401681075 -6.944750163724585 0.6137811643395201 0.9878040542228779 2.729262133860141 0.9987222199555295 0.021373282011812593 0.0856648156207689 0.045232204577469175 0.021648377178486063 0.09355433357578129 1.1356639403742438e-07 6.944750163724585 1.7414580796372632 up SNNVEMDWVLK(ub)HTGPNSPDTANDGFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNNVEMDWVLKHTGPNSPDTANDGFVR 27 1 P31943;G8JLB6;E9PCY7;D6RBM0;E5RGV0;D6RIU0;D6RIT2;D6R9T0;D6RFM3;D6RAM1;D6RDU3;D6RJ04;D6RIH9;E7EQJ0;E5RGH4;H0YAQ2 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 131758800.0 9354700.0 20217100.0 102187000.0 True False 12109843.558704965 19092000.61274081 83590014.52716304 1.0 1.5765687244586108 6.9026502383737 23.529676891874796 -6.927522650338306 0.7668509776086158 0.9111303349306271 7.930153027876648 0.9960286223439602 0.16744642060799741 0.09394468705612094 0.08413171784491133 0.15036137421615708 0.4886475293165252 1.1816186844053337e-07 6.927522650338306 7.019022692946021 up SNPDELK(ub)TTVEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNPDELKTTVEER 13 1 J3KNN7;Q7Z569 J3KNN7 BRAP BRCA1-associated protein 1 2386950.0 0.0 945650.0 1441300.0 True False 0.0 1323252.9764996038 1063780.2919268277 0.0 SNPDELK(ub)TTVEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNPDELKTTVEER 13 1 J3KNN7;Q7Z569 J3KNN7 BRAP BRCA1-associated protein 1 16904500.0 2709600.0 7919700.0 6275200.0 True False 4110661.298294207 6506367.658101475 5034903.969482132 1.0 1.5828031516003056 1.2248403855534038 21.970939073942677 -10.10061841083106 4.383166311829957 0.9999562264083489 1.4038217686084968 0.6291965021143717 0.1461376873970156 21835579.863605354 25228949.96027783 7757.113491303205 0.05002681871553903 7.931979610630991e-11 10.10061841083106 0.4038655422001479 SNPDELK(ub)TTVEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNPDELKTTVEER 13 1 J3KNN7;Q7Z569 J3KNN7 BRAP BRCA1-associated protein 1 2924490.0 1113600.0 1077800.0 733090.0 True False 1525328.013908446 1030179.2321920202 559949.2404624757 1.0 0.675382096702155 0.3671008696861744 20.540688089477218 -7.257254180331855 0.2447232143154321 1.1211101301728528 1.392811503965354e-14 0.999957519566895 0.0016842207428897449 0.09945155486614897 0.014228888095684854 0.014086791957932847 0.043591042642337714 5.5302634373211046e-08 7.257254180331855 -1.1211101301728388 down SNPDELK(ub)TTVEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNPDELKTTVEER 13 1 J3KNN7;Q7Z569 J3KNN7 BRAP BRCA1-associated protein 1 3320500.0 0.0 2117800.0 1202700.0 True False 0.0 2106390.9910496157 1454179.0093435019 0.0 SNPDELK(ub)TTVEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNPDELKTTVEER 13 1 J3KNN7;Q7Z569 J3KNN7 BRAP BRCA1-associated protein 1 22644900.0 2709600.0 11021500.0 8913800.0 True False 3507630.614201088 10408143.83632285 7291579.863311644 1.0 2.9672861772229258 2.07877643495035 21.742065396035127 -10.442655057905226 7.460241289533061 0.9998941309895406 2.523031306086627 0.7966532173877668 0.3627325833432666 0.0006387798151713011 4.772239439514921e-05 0.35123755623987596 0.1170714378679388 3.6086514944795394e-11 10.442655057905226 1.5231371750970866 SNPDQPAVILLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNPDQPAVILLLR 13 0 Q6PGP7 Q6PGP7 TTC37 Tetratricopeptide repeat protein 37 0 4311800.0 1251700.0 1144300.0 1915800.0 False True 1640990.8214800435 973574.9004464642 1717571.3936512494 1.0 0.5932847933715906 1.046667276360593 20.64613573880209 -6.670214885575541 1.9362190669845485 0.74045279548055 1.0448533549066883 0.28020086965891533 0.17275338863127576 0.4606031565540205 3.3291536490403564 0.0718169231386425 0.1918504629314357 2.1369045039377926e-07 6.670214885575541 0.3044005594261383 SNPDQPAVILLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNPDQPAVILLLR 13 0 Q6PGP7 Q6PGP7 TTC37 Tetratricopeptide repeat protein 37 0 4777000.0 1251700.0 2180500.0 1344800.0 False True 1714487.315920619 2084158.3000507532 1027185.9370253818 1.0 1.215616050756044 0.5991213393572523 20.709345800324982 -6.8122341496940635 1.405268178604213 1.1172029531500638 0.5877919958140898 0.8655351642217232 0.09366950194438783 0.20377788621307721 0.7927161457846915 0.052407099850441737 0.1211019835889386 1.5408694698068592e-07 6.8122341496940635 -0.529410957335974 SNPGNNMACISK(ub)NQGSELSGVISSACDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNPGNNMACISKNQGSELSGVISSACDK 28 1 O43683-2;O43683-3;O43683;A0A590UK50 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 16983400.0 5817200.0 7853600.0 3312600.0 True False 7967976.043919006 7506601.983617792 2530232.10513852 1.0 0.9420964548891527 0.3175501647083315 22.92578187920868 -6.924991574476743 0.7868206187584164 1.0114634621759886 0.20428838086651716 0.9954588640917702 0.020820690997970577 0.09532319737175274 0.09104198056304812 0.01843098979954094 0.05814436513855365 1.1885252851794307e-07 6.924991574476743 -0.8071750813094715 down SNPSVFVIFQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNPSVFVIFQK 11 0 C9J6P4;Q7Z2W4;Q7Z2W4-4 C9J6P4 ZC3HAV1 Zinc finger CCCH-type antiviral protein 1 0 19037400.0 5650100.0 8446400.0 4940900.0 False True 7314165.83012164 7976350.415017689 4041706.8979151985 1.0 1.090534532614642 0.5525861720649533 22.802261905817783 -6.863619221042932 1.1674045759867746 1.0496717233644357 0.5246881779277807 0.9578845549802718 0.0482626554374572 0.14311475350939554 0.3685966649024865 0.03219546755655487 0.07548242060846141 1.3689285432015387e-07 6.863619221042932 -0.524983545436655 SNPYFEFVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNPYFEFVLK 10 0 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 0 3978360.0 946520.0 702440.0 2329400.0 False True 1296474.0227412179 671403.8781415512 1779243.6954989042 1.0 0.5178691330212379 1.372371265670974 20.306161868737224 -6.753598629098551 1.6362954812936066 0.7177388162984439 1.374572137463037 0.6644144607875078 0.20264230338575262 0.29380304864213236 1.5487240472957708 0.09778186950182118 0.23651962578473698 1.7636052009157904e-07 6.753598629098551 0.6568333211645931 SNPYYIVK(ub)QGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNPYYIVKQGK 11 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 3088660.0 737560.0 1048200.0 1302900.0 True False 966948.3025412003 891812.6458515978 1168088.4062993065 1.0 0.9222960974313297 1.2080153646575496 19.883079233155275 -6.834262790223897 1.308835916480876 0.9585873287631126 1.216390818172203 0.9141189861091484 0.03534840088811572 0.1756101797709107 0.586830837319152 0.021195647602843638 0.048779167183479695 1.4646613108160523e-07 6.834262790223897 0.25780348940909037 SNPYYIVK(ub)QGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNPYYIVKQGK 11 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 5917900.0 1341100.0 1950800.0 2626000.0 True False 1298527.5145810265 2729764.6132876086 1938171.8216886504 1.0 2.102200055551672 1.4925920320710393 20.30844515302016 -10.502666002159208 6.2523264575389 0.9993803029583475 1.7973960438113525 0.6952442712240745 0.24887143343902285 0.002151298812599429 0.00017112244986925763 0.24113669140767685 0.08032290975467524 3.1429248575888184e-11 10.502666002159208 0.7980157408530051 SNPYYIVK(ub)QGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNPYYIVKQGK 11 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 15451000.0 4121200.0 4544300.0 6785500.0 True False 6252161.700077541 3733334.160222046 5444342.950809698 1.0 0.5971269361404623 0.8707936889639587 22.57592366066291 -10.647829997733018 5.415777626999766 1.0032936087643138 0.7339603125522111 0.5575317632740449 0.11172398399698946 0.004490483808088332 0.0002920008911816032 0.1093312166845128 0.03605876078269024 2.249935158641763e-11 10.647829997733018 -0.2693332962121028 SNPYYIVK(ub)QGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNPYYIVKQGK 11 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 3205460.0 737560.0 1137800.0 1330100.0 True False 1010255.8638095481 1087528.2337985528 1015957.7742693786 1.0 1.0764879202953797 1.0056440260968438 19.946289294678166 -6.628030216316518 2.0877015072511917 1.0504642901887322 1.0059274330313248 0.110384397657743 0.03282580515221108 0.5641756713554297 4.683359013620839 0.012871863813888372 0.03636613917087354 2.3548854355348908e-07 6.628030216316518 -0.044536857157407406 SNPYYIVK(ub)QGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNPYYIVKQGK 11 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 5450600.0 1341100.0 2809700.0 1299800.0 True False 1115184.07080355 2794563.588418219 1571582.1704038265 1.0 2.505921364537233 1.4092580871168803 20.088850428454435 -10.452782261138475 5.029017990726364 0.9983048363772725 1.9575897258271089 0.5041164053208247 0.44771090822153725 0.008521050338203658 0.0009271920077331652 0.4340924428719296 0.14449807428809158 3.5254758079169044e-11 10.452782261138475 0.9592848894498364 SNQQLVDIIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNQQLVDIIEK 11 0 P61289;P61289-3;P61289-2;K7ESG5;K9J957;B3KQ25;K7ENH2;K7EMD0;K7EPX6;K7EKR3 P61289 PSME3 Proteasome activator complex subunit 3 0 11935900.0 5432100.0 2017200.0 4486600.0 False True 5259660.958881207 2822678.4795590336 3311424.8648851058 1.0 0.5366654812213316 0.6295890344972893 22.326538374791312 -9.93279403289905 5.642363975468944 1.000000396678805 0.583127257858736 0.9640734100762812 0.037935881770852865 1.892832029849443e-07 3.579497234331349e-08 0.03673129460829823 0.012243753193209493 1.1673631156683575e-10 9.93279403289905 -0.41687313882006893 SNQQLVDIIEK(ub)VKPEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNQQLVDIIEKVKPEIR 17 2 P61289;P61289-3;P61289-2;K7ESG5;K9J957;B3KQ25;K7ENH2;K7EMD0;K7EPX6;K7EKR3 P61289 PSME3 Proteasome activator complex subunit 3 1 21308200.0 9552400.0 6528600.0 5227200.0 True False 9249164.290719412 9135504.026199227 3858039.5073613464 1.0 0.9877112935885212 0.4171230379411136 23.140891585969072 -6.911548115026301 0.885114656988154 1.0168135748538634 0.3408862231154507 0.9914929716650914 0.025080206392053356 0.10340368970924957 0.13327619486829817 0.020691930817619688 0.05775161430711864 1.2258910799780977e-07 6.911548115026301 -0.6759273517384127 down SNQQLVDIIEK(ub)VKPEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNQQLVDIIEKVKPEIR 17 2 P61289;P61289-3;P61289-2;K7ESG5;K9J957;B3KQ25;K7ENH2;K7EMD0;K7EPX6;K7EKR3 P61289 PSME3 Proteasome activator complex subunit 3 1 28870800.0 13905000.0 6052800.0 8913000.0 True False 21094901.59166705 4972630.549257742 7151341.643293316 1.0 0.23572665308009974 0.3390080589955562 24.330391021569934 -10.750109076713946 7.077179626973076 1.0121434687962714 0.287367356037828 0.9844909267613904 0.042164457401689406 0.007906670262289773 0.00027917934547151685 0.03995530195517906 0.0136085201098846 1.777832836282665e-11 10.750109076713946 -0.7247761127584433 SNQQLVDIIEK(ub)VKPEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNQQLVDIIEKVKPEIR 17 2 P61289;P61289-3;P61289-2;K7ESG5;K9J957;B3KQ25;K7ENH2;K7EMD0;K7EPX6;K7EKR3 P61289 PSME3 Proteasome activator complex subunit 3 1 17817000.0 9552400.0 7029600.0 1235000.0 True False 7943243.843071983 6991730.14953364 1493232.7900051745 1.0 0.8802109424894158 0.18798778175588263 22.92129686140335 -6.93663542016276 0.6901536071556795 1.0084045388857832 0.018450439733836987 0.9976891768870979 0.017205024129362433 0.08933565007938676 0.06185397701417803 0.01634811595387051 0.06051397809173489 1.157083178268323e-07 6.93663542016276 -0.9899540991519462 down SNSLISIK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNSLISIKR 9 1 O75643;O75643-2 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 1 3641300.0 855400.0 1442600.0 1343300.0 True False 1121437.6837053841 1227369.7032107576 1204308.2018434722 1.0 1.0944609058930137 1.0738966768659606 20.09691802398193 -10.106874312588184 4.573279018222689 0.9999931607497561 1.0841787913234067 0.9571584854632326 0.008395311353121413 5.931824810800433e-07 1.1584194316928179e-07 0.008129394381996271 0.0027095750869266895 7.818540450702164e-11 10.106874312588184 0.08418563057365058 SNSLISIK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNSLISIKR 9 1 O75643;O75643-2 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 1 3203400.0 855400.0 0.0 2348000.0 True False 1171664.4963158087 0.0 1793450.7585779282 1.0 0.0 1.5306862708712854 20.160128085504823 -6.730435672439431 1.7216996096925077 0.39848973765897383 1.5298363679816473 0.5612403249725604 0.4203623792535417 0.335431595013522 1.9481424721807468 0.19347004397220957 0.4798355180087637 1.8602200780239608e-07 6.730435672439431 1.1313466303226736 SNSLISIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNSLISIKR 9 1 O75643;O75643-2 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 1 4980900.0 1095400.0 2529900.0 1355600.0 True False 910873.634447997 2516270.9265541704 1639049.692413776 1.0 2.76248080018154 1.7994259910784052 19.796891397179444 -10.081881958487173 4.8840064338219005 0.9999579824178392 2.280953395640262 0.7022805277846789 0.39316547947488284 0.0001798892081260974 3.381700699419185e-05 0.3806932363503823 0.1268936128540925 8.281672294973296e-11 10.081881958487173 1.2809954132224228 SNSVEMDWVLK(ub)HTGPNSPDTANDGFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNSVEMDWVLKHTGPNSPDTANDGFVR 27 1 P55795 P55795 HNRNPH2 Heterogeneous nuclear ribonucleoprotein H2 1 14868500.0 1654200.0 4320400.0 8893900.0 True False 1601688.326463302 6045558.250588359 6564320.778719228 1.0 3.774491048416139 4.098375863932246 20.611162009447977 -10.026344185838926 0.501265934343135 8.021732397587379e-24 4.089120253539634 0.9992499254287482 0.03808364134921686 1.3167938219858009 0.23001506606510805 2.059982144411499 0.06541179037136435 9.411434285486392e-11 10.026344185838926 4.089120253539634 SNSVEMDWVLK(ub)HTGPNSPDTANDGFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNSVEMDWVLKHTGPNSPDTANDGFVR 27 1 P55795 P55795 HNRNPH2 Heterogeneous nuclear ribonucleoprotein H2 1 75162600.0 4645600.0 0.0 70517000.0 True False 6013820.778466404 0.0 57683629.56552161 1.0 0.0 9.591843802872958 22.51985044324366 -6.881161681375448 1.073339184160589 0.37022915243004023 10.286828517464787 0.9746087620721596 0.6860392577166738 0.12660420638734837 0.2661318564270319 0.49185050784531675 1.1929689998242896 1.3147352846825677e-07 6.881161681375448 9.916599365034747 up SNTAGSQSQVETEA ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNTAGSQSQVETEA 14 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 3754580.0 556280.0 1806600.0 1391700.0 False True 729288.4670231823 1537062.322071646 1247700.2341290554 1.0 2.107619126825965 1.7108459691155298 19.476130053907823 -10.118873489430875 4.6425024863414155 0.9999365029781107 1.9092325478272445 0.8750267120683813 0.16198196350043412 112964142.82099296 13.31754446239106 89114.28804988404 0.05545073454831741 7.605477932739679e-11 10.118873489430875 0.9092960448491338 SNTAGSQSQVETEA ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNTAGSQSQVETEA 14 0 Q02790 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 3760980.0 556280.0 1795400.0 1409300.0 False True 761951.7489017501 1716073.2914061577 1076452.3654445806 1.0 2.2522073003699306 1.4127566043337263 19.539340115430715 -10.269165201383403 5.611551906744877 0.9999632679533359 1.832481951989401 0.5673407592293889 0.34270431200083384 0.0002828005269269482 3.683107297563743e-05 0.3318480653232956 0.11060734102516637 5.3806506888104615e-11 10.269165201383403 0.832518684036065 SNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADK 38 1 Q16576;E9PC52;Q16576-2;Q5JP02;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 0 28633200.0 9343400.0 7304800.0 11985000.0 False True 12095215.485948669 6898281.458564736 9803852.976484783 1.0 0.5703314229150073 0.8105562887965228 23.52793313652567 -10.135826885708024 5.337799237599105 1.0000075501718682 0.6904438558556217 0.6888632339117418 0.0980713908235419 8.811982626771454e-06 1.4267593467111675e-06 0.09495953136294501 0.031652405283175485 7.314305812103825e-11 10.135826885708024 -0.3095636943162464 SNVGASGDHDDSAMK(ub)TLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNVGASGDHDDSAMKTLR 18 1 Q6S8J3;A5A3E0;Q6S8J3-3;A0A087X067;A6NC16;Q6S8J3-2 Q6S8J3 POTEE;POTEF POTE ankyrin domain family member E;POTE ankyrin domain family member F 1 17801700.0 1602500.0 8227600.0 7971600.0 True False 2100893.0186320776 7000074.1509336075 7146775.300986683 1.0 3.3319517409275123 3.4017797372852683 21.002571268499064 -10.447505310727678 0.6847774009974463 2.0248388778563054e-18 3.390234380189752 0.9999061788628931 0.010810837905437794 1.8318051268045703 0.34420734639115735 3.3294288072849376 0.011027902491288696 3.5685738546109684e-11 10.447505310727678 3.390234380189752 SNVGASGDHDDSAMK(ub)TLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNVGASGDHDDSAMKTLR 18 1 Q6S8J3;A5A3E0;Q6S8J3-3;A0A087X067;A6NC16;Q6S8J3-2 Q6S8J3 POTEE;POTEF POTE ankyrin domain family member E;POTE ankyrin domain family member F 1 8211810.0 1602500.0 4869710.0 1739600.0 True False 2194987.5559341647 4654550.110222496 1328742.3081866114 1.0 2.1205359901193455 0.6053530028424748 21.065781330021956 -6.708603808386556 1.8001441577061272 1.6898640562190828 0.6090530437113467 0.4584637254410756 0.4722927001028253 0.37790028312265395 2.3862511890201747 0.20885384303162366 0.5314946348388819 1.9561231445442417e-07 6.708603808386556 -1.080811012507736 SNVGASGDHDDSAMK(ub)TLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNVGASGDHDDSAMKTLR 18 1 Q6S8J3;A5A3E0;Q6S8J3-3;A0A087X067;A6NC16;Q6S8J3-2 Q6S8J3 POTEE;POTEF POTE ankyrin domain family member E;POTE ankyrin domain family member F 1 13396760.0 5355900.0 7071600.0 969260.0 True False 4453668.1566003505 7033503.887197294 1171927.7846481102 1.0 1.5792608788720863 0.26313765270349326 22.08656263605733 -6.787069594060015 1.508055534082465 1.3249835737525124 0.25025370249742473 0.7916881686321249 0.24581780469672743 0.23974320187256212 1.0771606640800795 0.12832641593539446 0.3010929709164885 1.6327902784178818e-07 6.787069594060015 -1.0747298712550877 down SNVGTSGDHDDSAMK(ub)TLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNVGTSGDHDDSAMKTLR 18 1 Q6S8J3;A5A3E0;P0CG38;Q6S8J3-3;A0A087X067;A6NC16;Q6S8J3-2;Q6S5H5;Q6S5H5-2;Q6S545;A0A087WTB9;A0A087X092;A6NI47;A0A087X187;A0A0D9SFE8;H0YG78;A0A494C1H2;A0A0H2UH41;Q6S545-2;Q6S5H5-4 Q6S8J3 POTEE;POTEF;POTEI;POTEG;POTEH;POTEM POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member G;POTE ankyrin domain family member H;Putative POTE ankyrin domain family member M 1 14477300.0 5059300.0 4129100.0 5288900.0 True False 6632791.294330898 3513054.375105737 4741655.362711191 1.0 0.529649467202198 0.7148808325634977 22.66118470045035 -10.140042261238966 5.260153821793589 1.0000113155865011 0.6222651498826038 0.8472063176799349 0.07562038824989123 1.003526010438901e-05 1.640566319695494e-06 0.07322131772392555 0.024406375360340956 7.243654685699249e-11 10.140042261238966 -0.3777461657038973 SNVGTSGDHDDSAMK(ub)TLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNVGTSGDHDDSAMKTLR 18 1 Q6S8J3;A5A3E0;P0CG38;Q6S8J3-3;A0A087X067;A6NC16;Q6S8J3-2;Q6S5H5;Q6S5H5-2;Q6S545;A0A087WTB9;A0A087X092;A6NI47;A0A087X187;A0A0D9SFE8;H0YG78;A0A494C1H2;A0A0H2UH41;Q6S545-2;Q6S5H5-4 Q6S8J3 POTEE;POTEF;POTEI;POTEG;POTEH;POTEM POTE ankyrin domain family member E;POTE ankyrin domain family member F;POTE ankyrin domain family member I;POTE ankyrin domain family member G;POTE ankyrin domain family member H;Putative POTE ankyrin domain family member M 1 10883100.0 5059300.0 3237800.0 2586000.0 True False 6929859.932441631 3094743.29002721 1975240.060341791 1.0 0.4465809295133652 0.28503318675964134 22.72439476197324 -13.999999999999996 0.17263037628655037 3.8106466092071907 0.14644793871738424 0.9995089066226398 0.006784463295401946 12.118199169569861 0.13161994960084925 11.409070787705264 0.12861923607838546 1.0000000000000082e-14 13.999999999999996 -3.6641986704898066 SNVQPTAAPGQK(ub)VMENSSGTPDILTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNVQPTAAPGQKVMENSSGTPDILTR 26 1 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;Q96GD4-2;J3QR41;Q96GD4-3;J3KRJ2;J3KRF8 Q96GD4-5 AURKB Aurora kinase B 1 8031000.0 2394200.0 3092900.0 2543900.0 True False 3138819.3854657817 2631451.376029775 2280681.6308118887 1.0 0.8383570549534132 0.7266049271176683 21.581790584803738 -6.975061708233072 0.06348626349122098 1.5465557353215662 0.015621768390571592 0.9999999585298978 2.2113664292959104e-05 0.07469167646887306 0.0018271631871570532 0.017857945731282316 0.02608907486393769 1.0591032281414838e-07 6.975061708233072 -1.5309339669309947 SNVQPTAAPGQK(ub)VMENSSGTPDILTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNVQPTAAPGQKVMENSSGTPDILTR 26 1 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;Q96GD4-2;J3QR41;Q96GD4-3;J3KRJ2;J3KRF8 Q96GD4-5 AURKB Aurora kinase B 1 17245800.0 5140600.0 3770500.0 8334700.0 True False 4977414.466822174 5276080.312897742 6151592.034359622 1.0 1.0600042146512767 1.2359011039494767 22.246965093838163 -6.951969361267185 0.5367868301997908 0.9973541833518348 1.306629491529793 0.9993469114503186 0.00255824297547993 0.08270442425305398 0.03276302226734863 0.002826360779719528 0.014559521186130376 1.1169420433516528e-07 6.951969361267185 0.3092753081779581 SNVQPTAAPGQK(ub)VMENSSGTPDILTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNVQPTAAPGQKVMENSSGTPDILTR 26 1 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;Q96GD4-2;J3QR41;Q96GD4-3;J3KRJ2;J3KRF8 Q96GD4-5 AURKB Aurora kinase B 1 10064300.0 2394200.0 3425500.0 4244600.0 True False 3279400.440822198 3274150.0833863164 3242112.900281037 1.0 0.9983989886167834 0.9886297690038084 21.64500064632663 -6.935475865531847 0.70035452881724 1.0001227692267172 0.9863122823943986 0.9975085316013231 0.0002507697626294666 0.08989128238015662 0.06446260010192117 0.00023643588697682996 0.0008588906047850946 1.1601766873087113e-07 6.935475865531847 -0.013810486832318558 SNVQPTAAPGQK(ub)VMENSSGTPDILTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNVQPTAAPGQKVMENSSGTPDILTR 26 1 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;Q96GD4-2;J3QR41;Q96GD4-3;J3KRJ2;J3KRF8 Q96GD4-5 AURKB Aurora kinase B 1 17011700.0 5140600.0 7340500.0 4530600.0 True False 4274636.667193143 7300955.26952483 5477927.51287243 1.0 1.7079709547148159 1.2814954671853793 22.02737036927244 -10.412262088084251 5.279145736631549 0.9996095036559589 1.4947332109501081 0.6421273810789758 0.17410788870867225 0.0008008174153350652 8.915671341451709e-05 0.16870845726183886 0.05619307945099644 3.870240131363558e-11 10.412262088084251 0.49512370729414923 SNVQPTAAPGQK(ub)VMENSSGTPDILTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNVQPTAAPGQKVMENSSGTPDILTR 26 1 Q96GD4-5;Q96GD4;Q96GD4-4;J3QLN8;J3KTD6;Q96GD4-2;J3QR41;Q96GD4-3;J3KRJ2;J3KRF8 Q96GD4-5 AURKB Aurora kinase B 1 70766900.0 7304600.0 8212300.0 55250000.0 True False 9455948.695192387 7755278.28580812 45195066.91287303 1.0 0.8201480925706666 4.779538084407247 23.17279077728121 -6.896257028012334 0.9845993672586267 0.8180550486402186 5.164985778715236 0.9846112096660627 0.22646357212695445 0.11421414629683857 0.19335182559443737 0.17364283679612114 0.4438878316976121 1.269822365244657e-07 6.896257028012334 4.346930730075018 up SNVSDAVAQSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNVSDAVAQSTR 12 0 P60174;P60174-3;P60174-4 P60174 TPI1 Triosephosphate isomerase 0 43666700.0 5478700.0 22374000.0 15814000.0 False True 7182628.755806268 19035886.41316893 14177718.978599446 1.0 2.6502673408786115 1.9738899866067157 22.77608051906572 -10.462217308200074 5.794439577521471 0.9989958223298339 2.3120786637426645 0.833815792431172 0.276129898589975 0.00358418868018451 0.00033264915421188325 0.26751782222212106 0.08912054155240928 3.449710827480435e-11 10.462217308200074 1.3130828414128306 SNVSDAVAQSTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNVSDAVAQSTR 12 0 P60174;P60174-3;P60174-4 P60174 TPI1 Triosephosphate isomerase 0 59516700.0 17197000.0 8430700.0 33889000.0 False True 16651090.648161866 11797122.475519711 25012454.251792345 1.0 0.7084894752417921 1.5021511071140257 23.989113341277566 -6.807270987576468 1.425799095319385 0.8406063392576258 1.51520885824597 0.8526236338854235 0.12583843053334795 0.21054647986458605 0.8440604241423749 0.06940533960070935 0.16076938037532185 1.558579689340189e-07 6.807270987576468 0.6746025189883441 SNVSDAVAQSTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNVSDAVAQSTR 12 0 P60174;P60174-3;P60174-4 P60174 TPI1 Triosephosphate isomerase 0 208561000.0 12218000.0 182070000.0 14273000.0 False True 18535599.25544681 149578185.9805973 11451935.293921873 1.0 8.06977880343646 0.6178346400403885 24.14379542241613 -6.658094655321047 1.9800926538974895 5.557831514087357 0.6492221206862175 0.2274862067076081 3.011519778663798 0.4888878041964311 3.6829068674098973 1.229761288097561 3.336853589844458 2.1973808971797338e-07 6.658094655321047 -4.908609393401139 SNVSDAVAQSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNVSDAVAQSTR 12 0 P60174;P60174-3;P60174-4 P60174 TPI1 Triosephosphate isomerase 0 47089700.0 5478700.0 20085000.0 21526000.0 False True 7504323.446300461 19197578.287786916 16442002.141886087 1.0 2.558202404941792 2.1910039272083606 22.83929058058861 -10.099770149572702 5.483920414983727 0.999984100368325 2.3746031660755635 0.949199739547986 0.14990815079732087 2.9141443898493742e-05 4.783820524884031e-06 0.14514961527545678 0.04838264762464927 7.947487443431482e-11 10.099770149572702 1.3746190657072386 SNVSDAVAQSTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNVSDAVAQSTR 12 0 P60174;P60174-3;P60174-4 P60174 TPI1 Triosephosphate isomerase 0 25582800.0 17197000.0 5877700.0 2508100.0 False True 14300067.456273671 5846035.663467894 3032532.1138558574 1.0 0.4088117543042179 0.21206418243330988 23.769518616711842 -13.99999999997294 0.15372777959126185 3.8762987503268285 0.004612836122293285 0.9995542776434374 0.007069170303521267 11.973706937899673 0.12366127010784443 10.278014612320193 0.1876971887104586 1.0000000000623063e-14 13.99999999997294 -3.871685914204535 SNVSDAVAQSTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNVSDAVAQSTR 12 0 P60174;P60174-3;P60174-4 P60174 TPI1 Triosephosphate isomerase 0 38190000.0 12218000.0 12964000.0 13008000.0 False True 15816441.852785999 12242542.00372811 10640677.473351194 1.0 0.7740389474242994 0.6727605091202534 23.91492174450858 -13.999999999998984 0.10847897209209924 2.0933254015691376 0.48283359150926053 0.9997507916797154 0.0021593911444818966 12.021761068214994 0.09969234341834629 2.8871047817525572 0.168764319752326 1.0000000000023396e-14 13.999999999998984 -1.610491810059877 SNWQNYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNWQNYR 7 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 4252000.0 1297400.0 1420700.0 1533900.0 False True 1700903.964039473 1208737.0978452258 1375186.7422077719 1.0 0.7106439419275611 0.8085034612664691 20.69787025558395 -10.77784218955989 10.042943208623669 1.0014120942886842 0.7595737015970151 0.8894802716294434 0.03995098147572454 0.0012692153266114445 2.807602263146566e-05 0.03886817243938858 0.012894123826676845 1.6678531535343417e-11 10.77784218955989 -0.24183839269166907 SNWQNYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNWQNYR 7 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 3656900.0 1298000.0 1235800.0 1123100.0 False True 1256795.700489277 1729261.3846118636 828926.4177222092 1.0 1.3759287877406434 0.6595554212983892 20.26131871960313 -6.7640905282671735 1.5968601280045915 1.217242098711841 0.6563747389027738 0.7075412498604506 0.15822446483095537 0.2760881333398498 1.3883532731220973 0.07814286675777449 0.1870550816811822 1.721509690543006e-07 6.7640905282671735 -0.5608673598090673 SNWQNYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNWQNYR 7 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 14478000.0 5696000.0 6889400.0 1892600.0 False True 8641248.433379035 5659932.742872117 1518526.780443953 1.0 0.6549901656581446 0.17573002236323332 23.042808328302282 -7.40624952682277 0.4457281632237326 1.022738430118926 9.595827427986184e-28 0.9986927471577443 0.01222039573228068 0.11164250429987492 0.04859091805675819 0.016319329288389174 0.06163441792602243 3.924194034012612e-08 7.40624952682277 -1.022738430118926 down SNWQNYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNWQNYR 7 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 4308600.0 1297400.0 1629500.0 1381700.0 False True 1777083.8409166823 1557503.3019640923 1055370.9170047368 1.0 0.8764377156007886 0.5938779548298292 20.761080317106842 -6.957342893827821 0.4713978262208459 1.0073627051047833 0.45134222972407606 0.9996585781793624 0.003140841656458728 0.08066440419447668 0.024745338080122824 0.00391718138765748 0.023318932883880965 1.1032072472594227e-07 6.957342893827821 -0.5560204753807072 SNWQNYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNWQNYR 7 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 3640330.0 1298000.0 1629100.0 713230.0 False True 1079344.5111498064 1620323.7149489692 862363.0953970776 1.0 1.501210872164317 0.7989692693006959 20.041723995037405 -6.715047906699827 1.7768664401273695 1.3065258255967473 0.8003359186466951 0.48918091209820747 0.2110489582908769 0.36502545948203285 2.2494461585781194 0.09440585818587971 0.23840956206545025 1.9273123010846166e-07 6.715047906699827 -0.5061899069500523 SNWQNYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNWQNYR 7 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 10870500.0 5696000.0 2734000.0 2440500.0 False True 7373584.284945904 2581850.496620847 1996354.0416446468 1.0 0.3501486382805738 0.27074404583947775 22.81393465039473 -13.999999999999998 0.29651367728817557 6.810524465980797 0.25049184424164816 0.999642042304968 0.006180539559734723 16.364838412064962 0.17283806347379996 58.221989331390745 0.029133402945455404 1.0000000000000041e-14 13.999999999999998 -6.560032621739149 SNYFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNYFLK 6 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VYN4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 35417400.0 7544400.0 13088000.0 14785000.0 False True 9890781.460073536 11135321.416624412 13255190.027734479 1.0 1.1258282736884597 1.340155990832693 23.237653080605213 -6.963059091260348 0.38993461979585164 0.9868271782109708 1.4868572483292426 0.9998673699400258 0.0016172077959074943 0.07862593795509022 0.017222016304987816 0.0027673134834001988 0.01802935302253774 1.0887819406928528e-07 6.963059091260348 0.5000300701182718 SNYFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNYFLK 6 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VYN4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 33781900.0 10740000.0 7295900.0 15746000.0 False True 10399064.578778783 10209190.91761588 11621650.230125464 1.0 0.9817412749267491 1.1175668871065185 23.309950424476767 -6.872992214867775 1.118089435798024 0.9894598609219243 1.125989268392607 0.9675820887866102 0.010836931174391062 0.13402106185710372 0.311312561901636 0.007507272424447637 0.017872873866524894 1.3397007025909098e-07 6.872992214867775 0.13652940747068265 SNYFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNYFLK 6 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VYN4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 36337400.0 7544400.0 16094000.0 12699000.0 False True 10333768.559743967 15382913.864259029 9699757.744114615 1.0 1.4886063854946796 0.9386466987368778 23.300863142128104 -6.672305031525718 1.9290573166077458 1.311254566265604 0.9408398266509818 0.289335449407611 0.20743967552959164 0.4558622005345342 3.272589302841553 0.08650054286721603 0.2304275464245496 2.1266448488149418e-07 6.672305031525718 -0.37041473961462235 SNYFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNYFLK 6 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VZS0;Q8NHW5;F8VQY6;F8VRK7;F8VS58;F8VYN4 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 19866800.0 10740000.0 5522800.0 3604000.0 False True 8930785.862672528 5493047.58021003 4357579.736986759 1.0 0.615068781703634 0.48792791631024035 23.090355699911044 -13.999999999999998 0.15482699382821102 2.876497170690064 0.35552338356229723 0.9995509358029977 0.004613387844317277 11.979165227186135 0.1241503073509339 6.754954295004978 0.11994006397117243 1.0000000000000041e-14 13.999999999999998 -2.5209737871277667 SNYNFEK(ub)PFLWLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNYNFEKPFLWLAR 14 1 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 1 20780900.0 12113000.0 0.0 8667900.0 True False 11728479.445320973 0.0 6397516.958573899 1.0 0.0 0.5454685740295313 23.483512649539502 -10.178678182698555 5.7561092450485125 1.0000136167983935 0.27273428701474217 0.7032819443444348 0.22268661284940275 3.8914396530342775e-05 5.552380151649419e-06 0.21561941403289311 0.07187179524907715 6.627073957487464e-11 10.178678182698555 -0.7272793297836513 SNYNFEK(ub)PFLWLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNYNFEKPFLWLAR 14 1 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 1 32462700.0 12113000.0 15573000.0 4776700.0 True False 10072496.196885683 15489105.158001509 5775485.885034584 1.0 1.5377623237813272 0.5733917166253494 23.26391792497378 -6.7553621046318835 1.6298123211900422 1.3141616657656054 0.570643506169481 0.6717598391373026 0.22605997642941664 0.29079931442041335 1.521254111181486 0.10949386751432229 0.264362231358346 1.7564585090307606e-07 6.7553621046318835 -0.7435181595961244 SNYNFEKPFLWLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SNYNFEKPFLWLAR 14 1 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 369008980.0 76039600.0 119766900.0 173202480.0 False True 99688651.96853377 101898145.36771972 155281148.84510517 1.0 1.0221639409858143 1.5576612360463946 26.5709259493714 -6.915604628480813 0.8566935589336733 0.986210922069669 1.6358496808731111 0.9928700336535861 0.021769991083479715 0.10082822978879517 0.11952766438222377 0.018332723762058408 0.05280542551636995 1.2144939942123762e-07 6.915604628480813 0.6496387588034421 SNYNFEKPFLWLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SNYNFEKPFLWLAR 14 1 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 472665100.0 210671000.0 106581100.0 155413000.0 False True 203983364.42047513 149139489.04309392 114705673.0099382 1.0 0.7311355485620367 0.5623285670173231 27.603876259105952 -9.329741925826886 0.09175943716569324 1.702446035670145 6.1085245452603925e-12 0.9999670817759622 0.0010340330607696766 0.784149903188681 0.033888723565403955 0.3757725628230356 0.24164487726885756 4.680131697616246e-10 9.329741925826886 -1.7024460356640365 SNYNFEKPFLWLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNYNFEKPFLWLAR 14 1 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 448411100.0 132285800.0 180352300.0 135773000.0 False True 200687229.98741072 148167022.96604854 108937407.03858006 1.0 0.738298211477348 0.542821818037021 27.580373577991903 -7.241778042665704 0.1287089148163437 1.3282657862798615 3.208503726976783e-12 0.9999977400176651 0.00028150403357900917 0.09889835795871368 0.006403134446304097 0.02241589087245513 0.04129889148396129 5.7308884790866805e-08 7.241778042665704 -1.328265786276653 SNYNFEKPFLWLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SNYNFEKPFLWLAR 14 1 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 517564200.0 76039600.0 181527600.0 259997000.0 False True 104153495.01292427 173507110.4005013 198591063.40629733 1.0 1.6658789066941158 1.9067153088012498 26.63413601089429 -10.816906055119652 0.2042447255391606 2.776154949401988e-18 2.0926419729078 0.9993608772433575 0.009694772644655713 2.743512704508068 0.10986409040932694 1.4699349290020078 0.14514985705953823 1.5243824665761112e-11 10.816906055119652 2.0926419729078 SNYNFEKPFLWLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNYNFEKPFLWLAR 14 1 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 463635100.0 210671000.0 114936100.0 138028000.0 False True 175182270.8077358 114316916.41627043 166889016.63063487 1.0 0.6525598503157567 0.9526592837342378 27.38428153454023 -10.147963412648965 7.270891762492632 1.0000001259681026 0.8026095683949671 0.36582303433889496 0.12251508066226881 2.501332380836513e-07 2.9416672606309452e-08 0.11862479277434314 0.03954157225535212 7.11273432707551e-11 10.147963412648965 -0.1973905575731355 SNYNFEKPFLWLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNYNFEKPFLWLAR 14 1 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 480867500.0 132285800.0 171347700.0 177234000.0 False True 171246575.8429593 161812049.86826622 144979230.57440987 1.0 0.9449067759267492 0.8466109752019931 27.351499900084352 -6.962215480450603 0.40300273490183 1.0052277033034258 0.782683455016608 0.9998437263935375 0.0007930806890299199 0.07891906537785147 0.018275922101255893 0.0012645263108267027 0.008226539476767398 1.090898939469872e-07 6.962215480450603 -0.22254424828681785 SNYNLPMHK ddPTM_RPMI8226_Bortezomib_1h_R1 2 SNYNLPMHK 9 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 28724030.0 6574140.0 12082500.0 10067390.0 False True 8618761.204062326 10279838.097216126 9025713.056023937 1.0 1.1927280329301704 1.0472169772808881 23.039049091400788 -10.767235775634537 7.0764339556589295 0.9972964075726161 1.1199725051068175 0.47544554598506505 0.059404639712411514 0.002585977869007359 8.506009194619866e-05 0.05870201968807251 0.019172765024468474 1.7090872109105112e-11 10.767235775634537 0.12267609753420139 SNYNLPMHK ddPTM_RPMI8226_Bortezomib_2h_R1 2 SNYNLPMHK 9 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 30890120.0 8016800.0 6955520.0 15917800.0 False True 7762311.07217445 9732895.40855763 11748450.656235943 1.0 1.2538656745472532 1.5135248442117455 22.888054819155975 -6.970843440860954 0.23718012196831353 0.9034416320598644 1.8714330610092125 0.9999882330185257 0.0007191402327740286 0.07602996893906065 0.008044508868566643 0.0063327039373745715 0.02544309545546272 1.0694403330789887e-07 6.970843440860954 0.9679914289493481 SNYNLPMHK ddPTM_RPMI8226_Bortezomib_8h_R1 2 SNYNLPMHK 9 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 72346100.0 12638700.0 48725100.0 10982300.0 False True 19173831.912736572 40029725.21405607 8811643.59128691 1.0 2.0877269288808975 0.45956612279643555 24.192635354323944 -6.726662780006778 1.7353991358150709 1.657022455575274 0.461117930832437 0.5436783290800347 0.4573888241691865 0.34255565570069435 2.0194987780732605 0.20899802564444442 0.5205852131876951 1.8764509649257572e-07 6.726662780006778 -1.1959045247428368 SNYNLPMHK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SNYNLPMHK 9 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 31072640.0 6574140.0 11903400.0 12595100.0 False True 9004777.217453368 11377468.428720074 9620396.784226956 1.0 1.2634924944803603 1.0683658853414355 23.10225915292368 -10.38052891963856 3.583173332991033 0.9990024075392283 1.165929189969122 0.4908777788535429 0.07966010482457903 9785673.561283957 9778023.6524325 66827.4794964411 0.027269771344336457 4.163619945865133e-11 10.38052891963856 0.16692678242989367 SNYNLPMHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SNYNLPMHK 9 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 14072600.0 5666000.0 6019400.0 2387200.0 False True 4711530.046359636 5986972.297442642 2886352.482834298 1.0 1.2707065939372448 0.6126146823714811 22.167764213416365 -6.795008075109642 1.4761848293203608 1.1503226175421513 0.6046108989567706 0.8171448761418778 0.11548563874379492 0.2279784052038638 0.9812212072962189 0.06156032617325672 0.1436251509505935 1.6032155808202565e-07 6.795008075109642 -0.5457117185853807 SNYNLPMHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNYNLPMHK 9 0 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 0 7464030.0 2284700.0 2546300.0 2633030.0 False True 2957589.188169928 2404596.166622408 2153845.5571692726 1.0 0.8130257495667625 0.7282436539139538 21.495990244022916 -13.999999999999535 0.10659098788099405 1.908145675474136 0.564793233545442 0.9997603913116853 0.001757335132838038 12.033746427865086 0.09849626815524577 2.36770381343369 0.1453283780495616 1.0000000000010716e-14 13.999999999999535 -1.343352441928694 SNYNLPMHK(ub)MINTDLSR ddPTM_RPMI8226_Bortezomib_1h_R1 2 SNYNLPMHKMINTDLSR 17 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 142670000.0 28521900.0 41083100.0 73065000.0 True False 37392487.10647252 34953661.62066954 65504934.688969955 1.0 0.9347776605803567 1.7518207468374378 25.156245097345078 -6.887578928951742 1.0365764696755986 0.9535177297534346 1.818854614197462 0.9793036981721832 0.05333574392550645 0.1211303933870297 0.2334872211159051 0.03932349731690434 0.09721937939334406 1.2954512400000748e-07 6.887578928951742 0.8653368844440273 SNYNLPMHK(ub)MINTDLSR ddPTM_RPMI8226_Bortezomib_2h_R1 2 SNYNLPMHKMINTDLSR 17 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 234451500.0 38283200.0 62056400.0 134111900.0 True False 37067920.77116421 86835844.13985083 98983970.11924067 1.0 2.342614377426909 2.6703405008959136 25.14366785740317 -10.235694163349839 0.31902417853149595 3.465434402199696e-25 2.7608502218549034 0.9989693182894599 0.023200240898866114 1.6814512999944466 0.1481624438779784 1.5597681444209202 0.10844690279323702 5.8117354452398945e-11 10.235694163349839 2.7608502218549034 SNYNLPMHK(ub)MINTDLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNYNLPMHKMINTDLSR 17 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 137082000.0 40942000.0 37446000.0 58694000.0 True False 62112007.26113138 30763468.733066585 47093105.173505895 1.0 0.49529020377220734 0.7581964784283496 25.888368856032333 -10.005503309142487 5.046564404455422 1.0000035745054523 0.6267433410969586 0.7288151467794376 0.10733103719212836 4.316671237175794e-06 8.506223799988042e-07 0.10392382544040661 0.03464094329637067 9.874081120809661e-11 10.005503309142487 -0.3732602334084937 SNYNLPMHK(ub)MINTDLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 3 SNYNLPMHKMINTDLSR 17 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 193863100.0 30318500.0 57904600.0 105640000.0 True False 41528068.77665517 55346183.30709423 80690007.72409377 1.0 1.3327415634171473 1.9430233598884166 25.307583446373343 -6.961702318377217 0.41073839239998394 0.9701780652133492 2.3282623010760037 0.99982821747123 0.005118195184980104 0.0790985310763137 0.018925064867319062 0.007860146206945291 0.05094184931497059 1.092188706781309e-07 6.961702318377217 1.3580842358626546 SNYNLPMHK(ub)MINTDLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 3 SNYNLPMHKMINTDLSR 17 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 182109500.0 41269500.0 74787100.0 66052900.0 True False 34317417.79884209 74384207.04822296 79864255.995897 1.0 2.1675350833282327 2.3272221839077796 25.032437666088708 -10.673407569417273 0.3904410913805071 9.523328490945799e-11 2.343365761717279 0.9993514922736189 0.015066153263139507 2.235463521893128 0.18774052563220467 2.1823134796085664 0.04181763945807335 2.1212528097633248e-11 10.673407569417273 2.343365761622046 SNYNLPMHK(ub)MINTDLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 3 SNYNLPMHKMINTDLSR 17 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 208201600.0 62946300.0 75368500.0 69886800.0 True False 81485226.20707344 71174176.72076379 57168119.49912364 1.0 0.8734611172323826 0.701576496257687 26.280035177421965 -6.96685320907367 0.32467864094812054 1.0222838528858662 0.5471712808491865 0.9999464041847405 0.0008953207657102392 0.0773376057648138 0.012671984291648541 0.0025578599219099225 0.015058234948223257 1.0793114663481012e-07 6.96685320907367 -0.47511257203667967 SNYYLNIHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SNYYLNIHLR 10 0 O75362 O75362 ZNF217 Zinc finger protein 217 0 35072900.0 9208100.0 11205500.0 14659300.0 False True 13969360.902281847 9205790.976028891 11761882.92960055 1.0 0.6589987215897012 0.8419771678802633 23.73576268322666 -10.058184648287112 4.922571121568007 1.0000057668455347 0.7504879460843643 0.7125824928550003 0.07470063789738009 103565640.60607156 16.674844318140316 6769.5038292378895 0.02557201527162193 8.746118388549127e-11 10.058184648287112 -0.24951782076117035 SNYYLNIHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SNYYLNIHLR 10 0 O75362 O75362 ZNF217 Zinc finger protein 217 0 24797600.0 9208100.0 10036000.0 5553500.0 False True 11920066.968786921 9477487.777646976 4542819.983721999 1.0 0.7950867895678844 0.38110691790721646 23.50688900531911 -6.959847416587524 0.4375832138476768 1.0151807292170119 0.14493722036700415 0.9997644865885548 0.003950517371210456 0.07975572954152742 0.021333450745180026 0.005442143919373783 0.03431692390684561 1.0968634964068048e-07 6.959847416587524 -0.8702435088500077 down SPAFVQLAPLSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPAFVQLAPLSSK 13 0 A6NEM2;P51610-2;P51610;P51610-4 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 4710700.0 0.0 2323200.0 2387500.0 False True 0.0 1976587.6157626708 2140464.4025171525 0.0 SPAFVQLAPLSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPAFVQLAPLSSK 13 0 A6NEM2;P51610-2;P51610;P51610-4 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 6259800.0 2115700.0 1214600.0 2929500.0 False True 2048538.2615756295 1699596.1140553239 2162176.066883813 1.0 0.8296628605550587 1.0554726301381256 20.966163408332243 -6.704926024538274 1.8134033732070767 0.8947416689372945 1.0548644322971885 0.44094688549663585 0.07183874996886379 0.3853568282683384 2.4669399236699254 0.03156513349404475 0.08068418955214056 1.9727587369535917e-07 6.704926024538274 0.16012276335989406 SPAFVQLAPLSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPAFVQLAPLSSK 13 0 A6NEM2;P51610-2;P51610;P51610-4 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 5845400.0 0.0 2344000.0 3501400.0 False True 0.0 2240434.3294285536 2674441.4335965766 0.0 SPAGLQVLNDYLADK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPAGLQVLNDYLADK 15 0 P24534;C9JZW3;F2Z2G2;F8WF65 P24534 EEF1B2 Elongation factor 1-beta 0 55789000.0 7895000.0 28756000.0 19138000.0 False True 10350421.455288768 24465716.890010066 17157783.34465895 1.0 2.3637411283874616 1.6576893432577873 23.30318617774056 -10.270448215549271 5.448692638727055 0.9998929651080649 2.0107152358226745 0.7320663799405855 0.28824443425832397 0.0003748224959622503 5.0186700817276495e-05 0.2791205166623829 0.09303049112659689 5.364778362268902e-11 10.270448215549271 1.0108222707146095 SPAGLQVLNDYLADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPAGLQVLNDYLADK 15 0 P24534;C9JZW3;F2Z2G2;F8WF65 P24534 EEF1B2 Elongation factor 1-beta 0 86615000.0 26381000.0 13894000.0 46340000.0 False True 25543549.595229287 19441946.6562528 34202163.8297989 1.0 0.7611294030914142 1.3389745893494287 24.606455683676828 -6.794421413994458 1.4784337707038093 0.8672612632311567 1.3459091160580345 0.8154075280536246 0.10186015640610666 0.22880905230556312 0.9878161136431982 0.05421557036364361 0.12654590438896876 1.6053827273692678e-07 6.794421413994458 0.47864785282687783 SPAGLQVLNDYLADK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPAGLQVLNDYLADK 15 0 P24534;C9JZW3;F2Z2G2;F8WF65 P24534 EEF1B2 Elongation factor 1-beta 0 184118000.0 13511000.0 155450000.0 15157000.0 False True 20497174.786408734 127708732.96360639 12161212.306450907 1.0 6.230552956414632 0.593311636026774 24.28892173479467 -6.662977311553136 1.9619984971731104 4.35860875271095 0.6165551058922508 0.24834263256567524 2.225489039060523 0.47751136331697586 3.5365299494118942 0.9153535225931412 2.468453148785511 2.1728146882564886e-07 6.662977311553136 -3.742053646818699 SPAGLQVLNDYLADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPAGLQVLNDYLADK 15 0 P24534;C9JZW3;F2Z2G2;F8WF65 P24534 EEF1B2 Elongation factor 1-beta 0 84000000.0 7895000.0 27152000.0 48953000.0 False True 10813994.854352716 25952334.860343084 37391309.61868204 1.0 2.3998841510357356 3.457677770544874 23.36639623926345 -7.669499637917178 0.18484511957618757 2.5546844019792977e-15 5.142448197982296 0.9999392727607666 0.0078440226136849 0.13741182941146424 0.02267620592305886 0.20596556319259948 0.34709860361233036 2.1404267113013746e-08 7.669499637917178 5.142448197982294 SPAGLQVLNDYLADK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPAGLQVLNDYLADK 15 0 P24534;C9JZW3;F2Z2G2;F8WF65 P24534 EEF1B2 Elongation factor 1-beta 0 41981000.0 13511000.0 15203000.0 13267000.0 False True 17490255.841626428 14356939.685488923 10852542.13091561 1.0 0.8208536121764279 0.6204907594940262 24.06004805688712 -6.9696767884881465 0.26579408179444286 1.0524180381460426 0.38293644267597804 0.9999797490102782 0.0006975592235363141 0.07640773668023046 0.009404843467765732 0.004031228866580386 0.018744994943633193 1.0723170503006124e-07 6.9696767884881465 -0.6694815954700646 SPAGSIVHELNPNFQPPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPAGSIVHELNPNFQPPK 18 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 8283400.0 1184300.0 4614400.0 2484700.0 False True 1552628.768777516 3925949.506790318 2227607.0789253884 1.0 2.528582225023094 1.43473257981644 20.56628149404874 -10.30564557654205 5.956299766516582 0.9999282018926484 1.9816574024197142 0.5178049026548304 0.44656224768012703 0.0004258617936473855 4.96447625220459e-05 0.4324132366263347 0.14412734569250588 4.9471425373087653e-11 10.30564557654205 0.9817292005270658 SPAGSIVHELNPNFQPPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPAGSIVHELNPNFQPPK 18 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 5810500.0 1470600.0 0.0 4339900.0 False True 1423916.6079657418 0.0 3203149.9957907693 1.0 0.0 2.2495348237892276 20.441433226304625 -6.785864530079792 1.5128374508997922 0.4380781906500982 2.2707994826876656 0.787633337092389 0.42408127901578857 0.24157699689843073 1.0922852620873984 0.2207028108511504 0.5183137384931716 1.6373271749131504e-07 6.785864530079792 1.8327212920375675 SPAGSIVHELNPNFQPPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPAGSIVHELNPNFQPPK 18 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 8684500.0 1184300.0 3913500.0 3586700.0 False True 1622167.7145041067 3740588.6297861175 2739595.3304052227 1.0 2.3059197864319523 1.688848388431101 20.629491555571633 -9.975214235375045 5.520904820643142 0.9999978066006583 1.9973840874329658 0.776950769910287 0.25191834333306135 6.8010067684790155e-06 1.2627162985531803e-06 0.243919421183318 0.08130629569369047 1.0587313292775169e-10 9.975214235375045 0.9973862808323075 SPALQILLTNTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPALQILLTNTK 12 0 F5H8H2;Q03426;A0A1B0GWC2 F5H8H2 MVK Mevalonate kinase 0 11071900.0 3190900.0 3544800.0 4336200.0 False True 4183300.800719556 3015929.6575221745 3887531.619767488 1.0 0.7209449669513162 0.9292976539240989 21.99621030818681 -10.305457264218429 5.206308538259475 1.0000423380776438 0.825121310963077 0.4843557634445941 0.08505962827026188 4.1811257033121834e-05 5.577749174211149e-06 0.08237854824295068 0.027452876977099597 4.9492881089185836e-11 10.305457264218429 -0.1749210271145668 SPALQILLTNTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPALQILLTNTK 12 0 F5H8H2;Q03426;A0A1B0GWC2 F5H8H2 MVK Mevalonate kinase 0 8703400.0 3765200.0 1918200.0 3020000.0 False True 3645675.786966284 2684147.263280854 2228971.401942009 1.0 0.7362550649393985 0.6114014334217107 21.797754836314606 -13.99999999969265 0.0994483136702327 2.3046498358841285 0.34318743919005124 0.9997964774093098 0.0023109239033432933 12.084673076075434 0.09380290442411636 3.2402820777912877 0.23928850394427192 1.0000000007077008e-14 13.99999999969265 -1.9614623966940772 SPALQILLTNTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPALQILLTNTK 12 0 F5H8H2;Q03426;A0A1B0GWC2 F5H8H2 MVK Mevalonate kinase 0 18629300.0 5711000.0 6368000.0 6550300.0 False True 8664004.53002592 5231580.646588904 5255630.333901515 1.0 0.6038293988026403 0.6066052153698253 23.04660256659223 -10.631634563346836 9.842525144571109 1.0000934785640598 0.6052173070862353 0.9999629215347579 0.0011332223681945256 2.325073648636322e-06 8.701805928761822e-08 0.0010974927185634202 0.0003657459466305956 2.3354223745291164e-11 10.631634563346836 -0.3948761714778245 SPALQILLTNTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPALQILLTNTK 12 0 F5H8H2;Q03426;A0A1B0GWC2 F5H8H2 MVK Mevalonate kinase 0 13999800.0 3190900.0 3262000.0 7546900.0 False True 4370661.960830152 3117874.0540085086 5764477.653284397 1.0 0.7133642642581097 1.3189026524919139 22.059420369709702 -6.777996927877222 1.543732232172507 0.8372740958836127 1.3233955746935082 0.760194954136867 0.12111575514417681 0.25371263522083765 1.1941181893333064 0.061803313230932556 0.14607248069182624 1.66725900640631e-07 6.777996927877222 0.48612147880989554 SPALQILLTNTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPALQILLTNTK 12 0 F5H8H2;Q03426;A0A1B0GWC2 F5H8H2 MVK Mevalonate kinase 0 7687000.0 3765200.0 1620600.0 2301200.0 False True 3130930.626641957 1611869.5061360842 2782370.280453368 1.0 0.5148212139931302 0.8886719676180007 21.578160111748883 -9.813562906772562 6.281653886702279 1.0000000105147322 0.7017465908054284 0.4590558217201687 0.15262393105647376 2.2551102098785556e-08 4.381919807634487e-09 0.14777749130852705 0.049259161934463405 1.536162266881437e-10 9.813562906772562 -0.29825341970930375 SPALQILLTNTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPALQILLTNTK 12 0 F5H8H2;Q03426;A0A1B0GWC2 F5H8H2 MVK Mevalonate kinase 0 15360300.0 5711000.0 5980500.0 3668800.0 False True 7393002.080640105 5647679.917717987 3001116.045066943 1.0 0.7639224033910993 0.40594010556630317 22.81772888868468 -6.965076151418036 0.35674313452589274 1.0320180518175137 0.12563863257218696 0.9999147059399854 0.002255482053270301 0.07793512957330369 0.014768888112931547 0.004836000689641447 0.030636864349077766 1.0837368693886008e-07 6.965076151418036 -0.9063794192453267 down SPAPPLLHVAALGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPAPPLLHVAALGQK 15 0 Q8N163;Q8N163-2;H0YC69;E5RFJ3;E5RGU7;H0YC58 Q8N163;H0YC58 CCAR2 Cell cycle and apoptosis regulator protein 2 0 17760800.0 6566700.0 6727500.0 4466600.0 False True 8609007.292013263 5723783.223589605 4004439.078652607 1.0 0.6648598414941134 0.46514527666477873 23.0374154588094 -9.52901654266402 0.1165506523554884 1.6734849554093294 5.201117655599712e-12 0.9999097200322956 0.00209674614200469 0.9913505158470528 0.046436127872675474 0.43394033778901747 0.22366227480223272 2.9578997953652986e-10 9.52901654266402 -1.6734849554041282 SPAPPLLHVAALGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPAPPLLHVAALGQK 15 0 Q8N163;Q8N163-2;H0YC69;E5RFJ3;E5RGU7;H0YC58 Q8N163;H0YC58 CCAR2 Cell cycle and apoptosis regulator protein 2 0 4086800.0 4086800.0 0.0 0.0 False True 3957066.771001222 0.0 0.0 1.0 0.0 0.0 21.915999978678155 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 SPAPPLLHVAALGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPAPPLLHVAALGQK 15 0 Q8N163;Q8N163-2;H0YC69;E5RFJ3;E5RGU7;H0YC58 Q8N163;H0YC58 CCAR2 Cell cycle and apoptosis regulator protein 2 0 25390300.0 3946900.0 17882000.0 3561400.0 False True 5987735.857040672 14690817.387296312 2857487.72898293 1.0 2.453484545418304 0.4772234108528613 22.513579149080087 -6.70960685597026 1.7964835761508369 1.8939196653386672 0.4818945864446459 0.46329260041478804 0.6125271645026417 0.375865495949998 2.3643656649579423 0.2713500966020156 0.6897172626086633 1.9516104910316073e-07 6.70960685597026 -1.4120250788940214 SPAPPLLHVAALGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPAPPLLHVAALGQK 15 0 Q8N163;Q8N163-2;H0YC69;E5RFJ3;E5RGU7;H0YC58 Q8N163;H0YC58 CCAR2 Cell cycle and apoptosis regulator protein 2 0 20058700.0 6566700.0 4769200.0 8722800.0 False True 8994586.448394928 4558480.974364619 6662654.291705098 1.0 0.5068027307890374 0.7407404809471857 23.10062552033229 -10.055854213606636 5.029943783228006 1.0000067058106858 0.6237716058660936 0.7752095489498266 0.09550468658403367 7.181997559683584e-06 1.3482805766075212e-06 0.09247366330138553 0.030824005051056598 8.793176415426525e-11 10.055854213606636 -0.37623509994459226 SPAPPLLHVAALGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPAPPLLHVAALGQK 15 0 Q8N163;Q8N163-2;H0YC69;E5RFJ3;E5RGU7;H0YC58 Q8N163;H0YC58 CCAR2 Cell cycle and apoptosis regulator protein 2 0 8400200.0 4086800.0 2080400.0 2233000.0 False True 3398355.2759376243 2069192.472272931 2699909.9757745382 1.0 0.6088805625839193 0.794475490803303 21.69640525411243 -10.048764379094033 4.9184771020986435 1.0000062525128535 0.7016780266906598 0.7750232177317602 0.0757688121745319 5.194984243592034e-06 1.0046671564504896e-06 0.07336437359404682 0.02445427897470039 8.937902666708845e-11 10.048764379094033 -0.29832822582219365 SPAPPLLHVAALGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPAPPLLHVAALGQK 15 0 Q8N163;Q8N163-2;H0YC69;E5RFJ3;E5RGU7;H0YC58 Q8N163;H0YC58 CCAR2 Cell cycle and apoptosis regulator protein 2 0 12990400.0 3946900.0 5914300.0 3129200.0 False True 5109339.855030363 5585164.005912469 2559717.708303395 1.0 1.0931283031434356 0.5009879516593996 22.284705471172536 -6.866682671414923 1.1514294439833903 1.0517531748405051 0.46841717155401946 0.9612625240519636 0.0511692507995018 0.14007913116117687 0.34917204090208814 0.03455237512354413 0.08136919174841228 1.3593062963991905e-07 6.866682671414923 -0.5833360032864856 SPAQYQVVLSER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPAQYQVVLSER 12 0 Q6XQN6;Q6XQN6-3 Q6XQN6 NAPRT Nicotinate phosphoribosyltransferase 0 18669000.0 4482400.0 5174000.0 9012600.0 False True 5876469.80762334 4402059.368094041 8080062.60696379 1.0 0.7490992912757592 1.3749858114614673 22.486518309335786 -6.797892375258714 1.464384776115122 0.861196845148795 1.383195612472403 0.8259773917708818 0.10728754953175293 0.22376999107854617 0.947542694497706 0.0576418890871826 0.13423656772779285 1.592603349350435e-07 6.797892375258714 0.521998767323608 SPAQYQVVLSER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPAQYQVVLSER 12 0 Q6XQN6;Q6XQN6-3 Q6XQN6 NAPRT Nicotinate phosphoribosyltransferase 0 2449100.0 0.0 2449100.0 0.0 False True 0.0 3427038.4018877805 0.0 0.0 SPAQYQVVLSER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPAQYQVVLSER 12 0 Q6XQN6;Q6XQN6-3 Q6XQN6 NAPRT Nicotinate phosphoribosyltransferase 0 18045400.0 4482400.0 0.0 13563000.0 False True 6139664.412305322 0.0 10359698.738753166 1.0 0.0 1.6873395747803268 22.549728370858677 -6.746145059679327 1.6641911799160216 0.4092790440198788 1.6897163697333137 0.6321994275955021 0.4201498618736534 0.30681096122852236 1.670589466720465 0.19954586655335063 0.4864053541722006 1.7941342639091765e-07 6.746145059679327 1.280437325713435 SPASDTYIVFGEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPASDTYIVFGEAK 14 0 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5 F8W0W4 NACA Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form 0 87098000.0 19566000.0 31676000.0 35856000.0 False True 25651215.477413513 26950064.272080936 32145965.07503869 1.0 1.0506349804675372 1.2531946138514938 24.61252385346258 -6.94487273024927 0.6125592331775596 0.9977671134527109 1.3166575233983095 0.9987349480271994 0.0038908453628073657 0.08561237065372183 0.04500381464788316 0.003945432407812831 0.017095852731041996 1.1353434786867949e-07 6.94487273024927 0.3188904099455987 SPASDTYIVFGEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPASDTYIVFGEAK 14 0 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5 F8W0W4 NACA Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form 0 69552200.0 25865000.0 9534200.0 34153000.0 False True 25043929.732785206 13341255.780196177 25207304.731962062 1.0 0.5327141515946291 1.0065235368778 24.57795762269511 -10.89813465611196 10.312020992816839 1.020512063115853 0.7696188442374423 0.2396757796646538 0.19343187154758837 0.08032184786431648 0.000793442854246821 0.16491650866479818 0.06242986809412854 1.2643442677027737e-11 10.89813465611196 -0.25089321887841076 SPASDTYIVFGEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPASDTYIVFGEAK 14 0 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5 F8W0W4 NACA Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form 0 76946000.0 19566000.0 27600000.0 29780000.0 False True 26800078.951268513 26380540.739005204 22746577.338352118 1.0 0.9843456352115167 0.8487503853892739 24.67573391498547 -6.928647709058098 0.7578077214666976 1.0021687712904312 0.8218481484566565 0.9962657587879505 0.0041499532144026454 0.09334611480624468 0.08116424910320302 0.0037508310881025093 0.01236152355389442 1.1785616113274303e-07 6.928647709058098 -0.1803206228337747 SPASDTYIVFGEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPASDTYIVFGEAK 14 0 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5 F8W0W4 NACA Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form 0 46490000.0 25865000.0 10360000.0 10265000.0 False True 21507893.513782576 10304188.623700995 12411364.040002542 1.0 0.4790886944413184 0.5770608838122225 24.358362898129386 -9.894106763968278 5.560330338605885 1.000000334766095 0.5280747891252564 0.9686884432443063 0.039996978829335054 1.659937989985329e-07 3.300350669556521e-08 0.03872693592260543 0.01290896940789664 1.276125056441097e-10 9.894106763968278 -0.47192554564083866 SPASDTYIVFGEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPASDTYIVFGEAK 14 0 F8W0W4;H0YHX9;Q13765;E9PAV3-2;E9PAV3;F8VNW4;F8VZJ2;F8W1N5 F8W0W4 NACA Nascent polypeptide-associated complex subunit alpha;Nascent polypeptide-associated complex subunit alpha, muscle-specific form 0 47735000.0 15610000.0 32125000.0 0.0 False True 20207452.719102103 30337215.50985545 0.0 1.0 1.501288456866099 0.0 24.268384136293605 -6.837427516968014 1.4353751270010984 1.2696604826295221 6.618327655257945e-22 0.8758509055923549 0.21988938769337382 0.18696723157165335 0.7732147702137923 0.12278341376997248 0.2635380012975726 1.4540270400700942e-07 6.837427516968014 -1.2696604826295221 down SPASSSSK(ub)NLAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPASSSSKNLAVK 13 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 25058000.0 7518800.0 8516900.0 9022300.0 True False 9857219.612162786 7246211.718616187 8088758.944012767 1.0 0.7351172038081726 0.8205923437103986 23.232749337893846 -10.480146237340547 8.663268623386022 1.0000069663324178 0.7778547737592856 0.9000601942199562 0.03489507974224328 4.695335441501059e-06 2.817010233158079e-07 0.033788074844876295 0.011262338558857348 3.310196404834179e-11 10.480146237340547 -0.22215219257313223 SPASSSSK(ub)NLAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPASSSSKNLAVK 13 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 36509200.0 10125000.0 10117200.0 16267000.0 True False 9803587.41714479 14157050.720501024 12006184.700460501 1.0 1.4440683923257291 1.2246725805151435 23.224878339150703 -10.115883467533507 4.347593940804286 0.9999532099667102 1.3343704864412742 0.7559175787098952 0.08956796519528629 62445092.368796706 2.9212717117975573 29950.945183161126 0.03066149684141538 7.658020638887884e-11 10.115883467533507 0.334417276474564 SPASSSSK(ub)NLAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPASSSSKNLAVK 13 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 39477000.0 2149000.0 9415600.0 27912400.0 True False 3260190.112944438 7735312.615581433 22395501.905560456 1.0 2.3726569149660084 6.869385259663271 21.636524664763666 -6.949457520541878 0.5647671677183023 0.9425910519099271 8.51612324431932 0.9991580265400767 0.07273798791236119 0.08370429837618594 0.036869437964964474 0.07752954485271421 0.37419946529003784 1.1234208489775425e-07 6.949457520541878 7.5735321924093935 SPASSSSK(ub)NLAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPASSSSKNLAVK 13 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 21965400.0 7518800.0 6792700.0 7653900.0 True False 10298703.547929982 6492576.053544946 5846206.457018566 1.0 0.6304265409066893 0.5676643113194225 23.295959399416738 -13.999999999999998 0.24944899178574623 3.563091195489469 0.5422960093539968 0.9995416559615894 0.004083555880793852 13.97624089370911 0.15804401197064813 17.943951785484135 0.0290534996962847 1.0000000000000041e-14 13.999999999999998 -3.020795186135472 SPASSSSK(ub)NLAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPASSSSKNLAVK 13 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 25088800.0 10125000.0 13029500.0 1934300.0 True False 8419386.113553002 12959307.49734673 2338753.1868072944 1.0 1.5392223759028756 0.27778191370063376 23.00528361458498 -6.790532146312932 1.4940872240108383 1.301155041705468 0.26414346133396344 0.8031039766045167 0.22931241717378642 0.23454452969770187 1.0343059673328305 0.12080064034802922 0.28272914666914944 1.619824090700886e-07 6.790532146312932 -1.0370115803715045 down SPASSSSK(ub)NLAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPASSSSKNLAVK 13 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 35834500.0 2149000.0 1900800.0 31784700.0 True False 2781922.863123021 1795018.8090625117 26000210.73856284 1.0 0.6452439184627144 9.346129284610962 21.407650986856115 -6.897396249324479 0.9776048972710242 0.6119538263902785 10.212568484365491 0.9852250795978367 0.4887160440474217 0.11334650993915205 0.18843614742367681 0.3767043794006485 0.967899758520013 1.2664957905803837e-07 6.897396249324479 9.600614657975212 up SPAVKPAAAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPAVKPAAAPK 11 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 4370380.0 370780.0 2385700.0 1613900.0 False True 486096.17063862766 2029762.8593857626 1446909.1096219595 1.0 4.1756405048801 2.9765902243603906 18.890882243365976 -9.28452088438518 10.193938128217766 1.0000016854165772 3.5761153646202684 0.860228323160704 0.48951022720343856 0.0 0.0 0.473966246501442 0.1579887464796021 5.193726972737862e-10 9.28452088438518 2.576113679203691 SPAVKPAAAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPAVKPAAAPK 11 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 3336010.0 1112500.0 651910.0 1571600.0 False True 1077184.2964517116 912221.0626657389 1159950.8130106174 1.0 0.8468570008592139 1.0768359851063019 20.038833672345113 -6.727196111191806 1.7332798584656626 0.9075524622279864 1.0766345699467235 0.546262665932648 0.06439330529162272 0.3415368342089518 2.008797853819673 0.029455504869445707 0.07332985281777331 1.8741480216073216e-07 6.727196111191806 0.1690821077187371 SPAVKPAAAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPAVKPAAAPK 11 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 5831120.0 428830.0 4729500.0 672790.0 False True 650566.4616723896 3885483.773247841 539812.7616056679 1.0 5.9724624648795395 0.8297580545698423 19.31133692419658 -6.65385374758139 1.9947320624772995 4.216819011878362 0.8513912800093124 0.209757334238451 2.120320372207634 0.4992221262018779 3.8117142045872408 0.8607612916284351 2.3491602759430394 2.2189435424003088e-07 6.65385374758139 -3.36542773186905 SPAVKPAAAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPAVKPAAAPK 11 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 3809080.0 370780.0 1886100.0 1552200.0 False True 507867.3859527418 1802765.8655013663 1185602.3285624618 1.0 3.5496783517993373 2.334472268461013 18.954092304888867 -9.536933035010774 13.80940765461202 1.0000143990092158 2.942075310129408 0.7730070155666104 0.4961058061538106 0.0 0.0 0.48035238126615576 0.1601174604220519 2.9044704677510394e-10 9.536933035010774 1.942060911120192 SPDAK(ub)ILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPDAKILR 8 1 H0Y4W2;F2Z2U4;Q9Y4A5-2;Q9Y4A5 H0Y4W2 TRRAP Transformation/transcription domain-associated protein 1 2585700.0 672220.0 841580.0 1071900.0 True False 881286.9297877391 716019.5444531464 960990.0703908411 1.0 0.812470400106356 1.0904394901468684 19.749252283352277 -6.724943049469994 1.7413125014068866 0.8865181975691551 1.0901384878660478 0.5358483050727347 0.07886905116580321 0.3457920289087442 2.0515801576150063 0.03592570043359067 0.08967422802987436 1.883896115073655e-07 6.724943049469994 0.20362029029689277 SPDAK(ub)ILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPDAKILR 8 1 H0Y4W2;F2Z2U4;Q9Y4A5-2;Q9Y4A5 H0Y4W2 TRRAP Transformation/transcription domain-associated protein 1 2216300.0 0.0 0.0 2216300.0 True False 0.0 0.0 1635784.5424251934 0.0 SPDAK(ub)ILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPDAKILR 8 1 H0Y4W2;F2Z2U4;Q9Y4A5-2;Q9Y4A5 H0Y4W2 TRRAP Transformation/transcription domain-associated protein 1 2959060.0 672220.0 926140.0 1360700.0 True False 920757.9000624405 885220.0724645738 1039330.6844961605 1.0 0.9614037223080499 1.1287773739716802 19.81246234487517 -6.846012973098306 1.2540898495144823 0.9794529621950944 1.1349740497562686 0.9343105532894841 0.018340737785703675 0.16189955031047412 0.491984232338169 0.01145431932055366 0.026448490799989326 1.4255650089689511e-07 6.846012973098306 0.15552108756117422 SPDAK(ub)ILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPDAKILR 8 1 H0Y4W2;F2Z2U4;Q9Y4A5-2;Q9Y4A5 H0Y4W2 TRRAP Transformation/transcription domain-associated protein 1 2575030.0 0.0 1592500.0 982530.0 True False 0.0 1583920.8864134983 1187972.480294564 0.0 SPDAK(ub)ILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPDAKILR 8 1 H0Y4W2;F2Z2U4;Q9Y4A5-2;Q9Y4A5 H0Y4W2 TRRAP Transformation/transcription domain-associated protein 1 6530600.0 2406200.0 1278500.0 2845900.0 True False 3114873.3332929807 1207350.3511081769 2327975.401399919 1.0 0.3876081695533316 0.747374018878267 21.570742066395084 -10.339772850191812 6.051038571921856 1.0000437456732474 0.567491094215867 0.6583570221052633 0.14687379295418584 8.668714009286415e-05 9.458447089900822e-06 0.14222426825259996 0.047403312842156306 4.573273237881072e-11 10.339772850191812 -0.4325526514573804 SPDNEDSGDSK(ub)DIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPDNEDSGDSKDIR 14 1 Q9H4A5;Q5T5I6;Q9H4A5-2 Q9H4A5 GOLPH3L Golgi phosphoprotein 3-like 1 4889300.0 1564700.0 1331300.0 1993300.0 True False 1515029.454973479 1862895.0326377843 1471194.9322817896 1.0 1.229609778557338 0.971066884179848 20.530914411953805 -6.67240758398279 1.928626963674163 1.1462586955413163 0.9720975286742649 0.2896987434415421 0.09748038924618661 0.45570485931441906 3.2700766924830544 0.04065528171030929 0.10828922394102618 2.1261427312059418e-07 6.67240758398279 -0.1741611668670514 SPDNEDSGDSK(ub)DIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPDNEDSGDSKDIR 14 1 Q9H4A5;Q5T5I6;Q9H4A5-2 Q9H4A5 GOLPH3L Golgi phosphoprotein 3-like 1 3233340.0 875260.0 999480.0 1358600.0 True False 1198867.2750121274 955319.6687616277 1037726.6612453029 1.0 0.796851902352547 0.8655892798765448 20.19324051808402 -10.43561316808782 8.244713673152633 1.000003750693981 0.8312205911145458 0.8893659582374323 0.028061916865141253 1.934690605677655e-06 1.324487151354913e-07 0.027171437715404145 0.00905694472344576 3.667641109073349e-11 10.43561316808782 -0.16878315957943513 SPDNEDSGDSK(ub)DIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPDNEDSGDSKDIR 14 1 Q9H4A5;Q5T5I6;Q9H4A5-2 Q9H4A5 GOLPH3L Golgi phosphoprotein 3-like 1 4774600.0 1564700.0 1594000.0 1615900.0 True False 1301117.3779631013 1585412.805615773 1953777.218922561 1.0 1.2185009842061567 1.5016148827257987 20.31131968738808 -6.967575864133213 0.31068268367781204 0.9567340878151829 1.7723900401789723 0.9999568232950882 0.0013493145954692654 0.07709740699671287 0.011831631820998174 0.004465679845592097 0.025118540697191084 1.0775170126787009e-07 6.967575864133213 0.8156559523637894 SPDTNYLFMGDYVDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPDTNYLFMGDYVDR 15 0 P67775;P67775-2;E7ESG8;E5RFI3;E5RHP4;E5RHC1;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0 6707300.0 1134000.0 1822700.0 3750600.0 False True 1486684.9816716204 1550760.2648289527 3362523.8902956336 1.0 1.0430994352854002 2.2617595063850247 20.503667551935187 -6.914397875690572 0.8652459765053334 0.9673108934296292 2.4350176910860553 0.9924781277872581 0.05072808470627636 0.10158123895898565 0.12352264980630023 0.042456896089819084 0.1210993348585278 1.2178733419862795e-07 6.914397875690572 1.467706797656426 up SPDTNYLFMGDYVDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPDTNYLFMGDYVDR 15 0 P67775;P67775-2;E7ESG8;E5RFI3;E5RHP4;E5RHC1;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0 7295640.0 1571300.0 841040.0 4883300.0 False True 1521419.9415861343 1176871.6579656594 3604217.2341402075 1.0 0.7735350548506212 2.36898251141804 20.53698698933149 -6.870935951569835 1.129202228667497 0.871178785365237 2.464068708583196 0.9656049012729115 0.1307140212707761 0.1359569960768992 0.32344490751384647 0.08978897475025362 0.21292038683266543 1.3460588520868434e-07 6.870935951569835 1.592889923217959 up SPDTNYLFMGDYVDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPDTNYLFMGDYVDR 15 0 P67775;P67775-2;E7ESG8;E5RFI3;E5RHP4;E5RHC1;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0 6423200.0 1134000.0 2467200.0 2822000.0 False True 1553270.4451977152 2358190.946060639 2155501.720914359 1.0 1.5182101438622724 1.3877182351460928 20.56687761345808 -9.976172450631838 4.702225761917929 0.9999932228764695 1.4529641893300842 0.9414028862320597 0.053273098747153115 8617224.825139502 9141086.885219088 498.45135119133863 0.01823679987697 1.0563979490403406e-10 9.976172450631838 0.4529709664536147 SPEDLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPEDLER 7 0 P06744;A0A2U3TZU2;P06744-2;Q8N196 P06744 GPI;SIX5 Glucose-6-phosphate isomerase;Homeobox protein SIX5 0 10808930.0 447230.0 6050300.0 4311400.0 False True 586322.8609814806 5147618.823884684 3865297.685869083 1.0 8.779495336865732 6.592438983870989 19.16133578357035 -9.312279630601152 9.191546461247725 1.0000835386455185 7.685967160368876 0.9257104227405665 0.8928620185632867 0.0 0.0 0.8645099057372553 0.288169977166502 4.872146845844955e-10 9.312279630601152 6.685883621723358 SPEDLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPEDLER 7 0 P06744;A0A2U3TZU2;P06744-2;Q8N196 P06744 GPI;SIX5 Glucose-6-phosphate isomerase;Homeobox protein SIX5 0 8618900.0 3236200.0 1077700.0 4305000.0 False True 3133468.6024063206 1508031.230131255 3177391.352768327 1.0 0.4812657860918648 1.0140172939113787 21.579329106608757 -10.841064763582843 11.90009844082362 1.0032409543148422 0.7476415400016222 0.23028067284530374 0.2174948923093619 0.018793533843680252 0.00025100214878449347 0.211625678291834 0.07019617464994447 1.4419003140388854e-11 10.841064763582843 -0.25559941431322 SPEDLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPEDLER 7 0 P06744;A0A2U3TZU2;P06744-2;Q8N196 P06744 GPI;SIX5 Glucose-6-phosphate isomerase;Homeobox protein SIX5 0 8016430.0 447230.0 3471200.0 4098000.0 False True 612583.0169363089 3317830.9062766237 3130136.800959262 1.0 5.416132694748837 5.10973486763298 19.224545845093242 -10.188589606953936 5.000522707311631 0.999626549976549 5.262933781196618 0.9961404556855964 0.12508638914168693 0.0005208218120924385 8.45126311983132e-05 0.12112268989113856 0.04037145849574871 6.477544318391597e-11 10.188589606953936 4.263307231220069 SPELVQAMFPK(ub)LNNQER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPELVQAMFPKLNNQER 17 1 Q9UBB4;Q9UBB4-2;A0A1W2PQD2 Q9UBB4 ATXN10 Ataxin-10 1 7669300.0 2350000.0 3552700.0 1766600.0 True False 1954129.1226518075 3533560.89994426 2135987.8921644865 1.0 1.8082535381024973 1.0930638448629697 20.89809436849063 -10.273093379503731 4.466048322508891 0.9997444666176363 1.4506586914865587 0.3461528855540279 0.2919749696353917 0.0007432954572912518 0.00012098101999572166 0.28286184947361537 0.09423451624045398 5.332202332107721e-11 10.273093379503731 0.4509142248689224 SPFAYCMMIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPFAYCMMIR 10 0 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 0 9979200.0 2406400.0 3362400.0 4210400.0 False True 3650684.7314050756 2762353.4494488947 3378212.594516121 1.0 0.7566672152447741 0.9253641010013797 21.79973565412616 -10.055484156524937 5.082973292322022 1.0000025142330904 0.8410156583025996 0.5421711852633384 0.06887021521902556 1.962282687269426e-06 3.6459602618190213e-07 0.06668435337422252 0.022227766382418673 8.800672167894007e-11 10.055484156524937 -0.15898685593049078 SPFLQVFNNSPDESSYYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPFLQVFNNSPDESSYYR 18 0 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 0 6343200.0 1263400.0 2331100.0 2748700.0 False True 1656329.634783003 1983308.96655663 2464290.8913922054 1.0 1.197411991494353 1.4878022101651607 20.659558388986003 -6.965580011929654 0.3479580035671312 0.9712696799586402 1.7237126341363775 0.9999246024111118 0.0017396360196700387 0.07776472253238113 0.014169280724118124 0.004007236822814972 0.02499400356643967 1.0824802667864953e-07 6.965580011929654 0.7524429541777373 SPFLQVFNNSPDESSYYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPFLQVFNNSPDESSYYR 18 0 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 0 7508700.0 1263400.0 2417000.0 3828300.0 False True 1730513.122101229 2310208.948049839 2924134.386313412 1.0 1.3349849351299516 1.6897499065264876 20.722768450508894 -6.970398499264339 0.24848214486098283 0.8852910030726192 2.1498144539726036 0.9999853262138444 0.001078798704258808 0.07617358526266735 0.008566142527061314 0.007994661641555772 0.03408582867654549 1.07053655314264e-07 6.970398499264339 1.2645234508999845 SPFLQVFNNSPDESSYYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPFLQVFNNSPDESSYYR 18 0 A0A2R8YFH5;Q15437;Q5QPE1 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 0 3917400.0 0.0 1592100.0 2325300.0 False True 0.0 1583523.0412928946 2811509.479027554 0.0 SPFSVAVSPSLDLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPFSVAVSPSLDLSK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 18963300.0 5020900.0 8341100.0 5601300.0 False True 6582448.52246476 7096640.393353139 5021731.207463583 1.0 1.0781155931768447 0.7628971484281696 22.6501929031534 -6.841118267169715 1.2771679613444034 1.0415511140850693 0.7522959212669599 0.926367964697353 0.03637002658630511 0.1674924328452086 0.5302188298717431 0.022325481146139123 0.05145069011091673 1.4417226878197875e-07 6.841118267169715 -0.2892551928181094 SPFSVAVSPSLDLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPFSVAVSPSLDLSK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 21404500.0 8732500.0 4205900.0 8466100.0 False True 8455291.567428824 5885337.803478751 6248574.432444131 1.0 0.6960537973817535 0.7390134784369435 23.011423073886217 -10.547894188866522 6.887594210730784 1.0002172928165367 0.7175336379093485 0.9829478011124002 0.017538216349654117 5.856376106059108e-05 3.844154536680122e-06 0.016994166075720137 0.005660434987032755 2.832081917748912e-11 10.547894188866522 -0.28268365490718816 SPFSVAVSPSLDLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPFSVAVSPSLDLSK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 20096900.0 5020900.0 5136300.0 9939700.0 False True 6877262.41472064 4909361.28252726 7592147.574547293 1.0 0.7138539998152277 1.1039490885641439 22.71340296467629 -6.710082762136042 1.7947023032210583 0.8241020717000322 1.1030435425800085 0.4656013455246152 0.1205784146136169 0.37490350258447247 2.353915698593575 0.05346243084287941 0.13581662679099676 1.9494730593965518e-07 6.710082762136042 0.2789414708799762 SPFSVAVSPSLDLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPFSVAVSPSLDLSK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 15476700.0 8732500.0 3513000.0 3231200.0 False True 7261460.665343364 3494074.7717240974 3906828.980619212 1.0 0.48118070630062104 0.5380224669211886 22.791828349320493 -10.181748954200383 6.226755977457974 1.0000039400273282 0.5096015866133465 0.990024284208169 0.02320555160030805 1.2692824910383987e-06 1.6679559200878461e-07 0.02246885911203291 0.007489559573961727 6.580381092049633e-11 10.181748954200383 -0.49040235341398164 SPGADLLQVLTK(ub)AVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPGADLLQVLTKAVK 15 1 Q3LXA3;H0YCY6;Q3LXA3-2;I3L252 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 1 1732270.0 382900.0 677680.0 671690.0 True False 524468.4774834267 647737.8568119208 513050.655889782 1.0 1.2350367746027013 0.9782297276503038 19.00049653847865 -6.665924141763773 1.9518147246719126 1.1505386715186234 0.9792815144014807 0.26127988527476365 0.09993174756550902 0.4704430077247519 3.4511260170791265 0.04127676008081026 0.11087090726657321 2.1581213353812787e-07 6.665924141763773 -0.17125715711714273 SPGAQLWLFPSAAGLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPGAQLWLFPSAAGLHR 17 0 Q9UII4 Q9UII4 HERC5 E3 ISG15--protein ligase HERC5 0 7114300.0 1789900.0 2828600.0 2495800.0 False True 2346576.2334162546 2406583.9057964403 2237558.557404108 1.0 1.0255724367807235 0.9535418136177772 21.16212589940485 -6.810732771074198 1.411481979457056 1.013924568132817 0.9522607600184371 0.8617294742840803 0.011086848842198105 0.20579988400262778 0.8079633718110184 0.006176051551983177 0.014281585621294357 1.5462055539798658e-07 6.810732771074198 -0.06166380811437999 SPGAQLWLFPSAAGLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPGAQLWLFPSAAGLHR 17 0 Q9UII4 Q9UII4 HERC5 E3 ISG15--protein ligase HERC5 0 5752800.0 2526700.0 1320100.0 1906000.0 False True 2446491.2915456556 1847222.8142305561 1406761.421225654 1.0 0.7550498220099975 0.575011824520693 21.22228271673185 -7.182394957032343 0.11532738875346212 1.3628238052351278 1.1767477761802492e-11 0.9999990267176128 0.00017173446262596582 0.0889419770636271 0.004831053662825756 0.019996359522980872 0.035670986076215785 6.570600206096416e-08 7.182394957032343 -1.3628238052233603 SPGAQLWLFPSAAGLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPGAQLWLFPSAAGLHR 17 0 Q9UII4 Q9UII4 HERC5 E3 ISG15--protein ligase HERC5 0 8233800.0 1789900.0 2485500.0 3958400.0 False True 2451674.400228739 2375682.391550632 3023507.445807014 1.0 0.9690040371302908 1.2332418389346171 21.22533596092774 -6.877660981228878 1.0928237314508924 0.9813261552980305 1.2511435763310352 0.9717464382399356 0.019823938962315216 0.12971915918045074 0.28501307584783153 0.014002462161845032 0.033667540836249454 1.3253757457225576e-07 6.877660981228878 0.26981742103300477 SPGDTAK(ub)DALFASQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPGDTAKDALFASQEK 16 1 Q5QNY5;P40855;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 74592000.0 19349000.0 21936000.0 33307000.0 True False 25366726.375982553 18663234.305858295 29860711.143304184 1.0 0.7357368084960626 1.1771606119257303 24.59643401310222 -6.744527551107712 1.6697494973867801 0.8436008294198498 1.1777040145709559 0.6252804076060625 0.11102824316318001 0.30966794331642583 1.6967995181570503 0.05256405848154416 0.12837055079406312 1.8008288884486396e-07 6.744527551107712 0.33410318515110604 SPGDTAK(ub)DALFASQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPGDTAKDALFASQEK 16 1 Q5QNY5;P40855;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 86184500.0 22386000.0 23731500.0 40067000.0 True False 21675368.68347685 33207611.708137587 29572250.715765096 1.0 1.5320436848417611 1.3643251539388137 24.369553197141926 -10.044286651811756 4.757193385480132 0.9999876989557275 1.4481844193336793 0.9049535016145893 0.06847080355515468 47398686.61561078 0.8567800269658324 6611.0767313766355 0.023439377268280256 9.030532255487358e-11 10.044286651811756 0.4481967203779518 SPGDTAK(ub)DALFASQEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPGDTAKDALFASQEK 16 1 Q5QNY5;P40855;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 211872600.0 28947600.0 117380000.0 65545000.0 True False 43915625.55303418 96432621.90587404 52590002.020605974 1.0 2.1958612838024667 1.1975236913589284 25.388231018480568 -6.601766607552035 2.183822620982827 1.8033047060553173 1.20079767227574 0.025718043885574637 0.5166519123048415 0.6356912668305443 5.732022938074139 0.19618362876581766 0.5745851839890751 2.501689423345654e-07 6.601766607552035 -0.6025070337795773 SPGDTAK(ub)DALFASQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPGDTAKDALFASQEK 16 1 Q5QNY5;P40855;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 69965000.0 19349000.0 19763000.0 30853000.0 True False 26502848.18706404 18889805.312498525 23566156.83748074 1.0 0.7127462369013826 0.8891933678653945 24.65964407462511 -10.348036850144732 5.592597059354255 1.0000449520877477 0.8009698028925157 0.6291454669927292 0.07203423957331719 4.0383455538186135e-05 4.7077851718960894e-06 0.06976258211798218 0.023248950852013527 4.4870731523562416e-11 10.348036850144732 -0.19907514919523195 SPGDTAK(ub)DALFASQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPGDTAKDALFASQEK 16 1 Q5QNY5;P40855;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 86446600.0 22386000.0 38234100.0 25826500.0 True False 18614950.867950357 38028125.314425394 31226701.741755974 1.0 2.0428807781544562 1.6775065356481524 24.149958472576202 -10.063988762062198 5.598103127049145 0.9999950488190681 1.860193656901582 0.880813126694161 0.14916340988370716 9.217655588547869e-06 1.540848243891034e-06 0.1444276807069905 0.04814228352845001 8.630008787546403e-11 10.063988762062198 0.8601986080825139 SPGDTAK(ub)DALFASQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPGDTAKDALFASQEK 16 1 Q5QNY5;P40855;E9PS71;B7Z8B3 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 230994500.0 28947600.0 150041000.0 52005900.0 True False 37473238.84250348 141691086.45336103 42541359.82559616 1.0 3.7811273012422393 1.1352464088944518 25.159357340573017 -6.634509384537185 2.0646305343337827 2.826231244843297 1.1461655520951128 0.13381493870355854 1.191608999577211 0.5473173718947342 4.452021883712176 0.47116181293091297 1.3193616579770022 2.320014052550934e-07 6.634509384537185 -1.6800656927481843 SPGETSK(ub)PRPFAGGGYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPGETSKPRPFAGGGYR 17 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 8689300.0 2859500.0 4264400.0 1565400.0 True False 3748832.1914373934 3628168.142501008 1403427.424377107 1.0 0.9678128967170121 0.3743638959307482 21.838009817196248 -6.9181030142391124 0.8386803050463048 1.014010822502792 0.2827208970369264 0.9936373992738231 0.022943979218086226 0.09930100514975432 0.11149455797664401 0.01957248357533214 0.05760624792094666 1.207527376786054e-07 6.9181030142391124 -0.7312899254658656 down SPGETSK(ub)PRPFAGGGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPGETSKPRPFAGGGYR 17 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 23241700.0 7068700.0 6307700.0 9865300.0 True False 6844307.987710748 8826397.504220957 7281281.977343884 1.0 1.289596774439306 1.0638448752478324 22.706473250592985 -10.619467494300718 5.563525998493405 0.9986504633630369 1.1767208248433727 0.4496589703043531 0.0921628269138896 0.0015540600773369597 0.00010629408503302824 0.08989102591024091 0.029745424481407552 2.4017760272215828e-11 10.619467494300718 0.17807036148033584 SPGETSK(ub)PRPFAGGGYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPGETSKPRPFAGGGYR 17 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 54325800.0 8999000.0 19055100.0 26271700.0 True False 13652140.915024195 15654568.526824184 21079086.979704823 1.0 1.1466749885064778 1.5440132877992248 23.70262387508511 -6.953719594782315 0.5163991122229826 0.9930553477571938 1.7152560179920706 0.9994617699575302 0.005331696641016058 0.08202568140401817 0.030040687798844095 0.006075350888667797 0.032809391739559865 1.1124497562888578e-07 6.953719594782315 0.7222006702348768 SPGETSK(ub)PRPFAGGGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPGETSKPRPFAGGGYR 17 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 12011600.0 2859500.0 5672100.0 3480000.0 True False 3916734.425081898 5421487.866873596 2658095.6728497404 1.0 1.3841857216960105 0.6786509843066932 21.90121987871914 -6.75884132435376 1.6168305966477603 1.223480863755101 0.6762210773348679 0.6861969973843584 0.16156404305986646 0.2848805718383394 1.4675016764744946 0.07885251393860586 0.18971253275689182 1.7424433834994567e-07 6.75884132435376 -0.547259786420233 SPGETSK(ub)PRPFAGGGYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPGETSKPRPFAGGGYR 17 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 23661200.0 7068700.0 13778100.0 2814400.0 True False 5877937.246505883 13703874.640561286 3402878.0276846644 1.0 2.331408803097975 0.5789238443652137 22.48687852602726 -6.703590928311416 1.8181313215121 1.8238329641731041 0.5837841600804722 0.4345922266077302 0.5616445889477418 0.38810569875972983 2.496611651978237 0.24621912028879 0.6304030286776143 1.9788326693215456e-07 6.703590928311416 -1.2400488040926319 SPGETSK(ub)PRPFAGGGYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPGETSKPRPFAGGGYR 17 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 58637000.0 8999000.0 34512000.0 15126000.0 True False 11649382.896809706 32591376.86151382 12373223.205866406 1.0 2.7976912725943 1.0621355067018126 23.47375019717756 -6.637922731612028 2.051516752386541 2.1773989276218586 1.0692540671720248 0.14686179569159485 0.769571226414697 0.5386186916402463 4.329762858275399 0.30571966931890876 0.8524059848352221 2.3018513195481124e-07 6.637922731612028 -1.1081448604498338 SPGLYFLTAGDQGTLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPGLYFLTAGDQGTLR 16 0 Q12788;J3KNP2;A0A087WYP7 Q12788 TBL3 Transducin beta-like protein 3 0 9108300.0 2397000.0 3218200.0 3493100.0 False True 3142490.212581023 2738057.1044453485 3131667.520181216 1.0 0.8713017127256217 0.9965560139673695 21.583476820642094 -10.703360976210694 7.3308050223088195 1.000441986427062 0.9339288633469789 0.2706067977552903 0.05113485435518923 0.00037183645300272556 1.5046249315639617e-05 0.04983966044095255 0.016503703277365802 1.9798807075465647e-11 10.703360976210694 -0.06651312308008306 SPGLYFLTAGDQGTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPGLYFLTAGDQGTLR 16 0 Q12788;J3KNP2;A0A087WYP7 Q12788 TBL3 Transducin beta-like protein 3 0 3008000.0 0.0 0.0 3008000.0 False True 0.0 0.0 2220114.561934294 0.0 SPGLYFLTAGDQGTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPGLYFLTAGDQGTLR 16 0 Q12788;J3KNP2;A0A087WYP7 Q12788 TBL3 Transducin beta-like protein 3 0 8629300.0 2397000.0 2550900.0 3681400.0 False True 3283235.6764893555 2438192.803301748 2811929.14081294 1.0 0.7426188807465746 0.8564505926116256 21.646686882164985 -10.139470441956005 4.754820743578806 1.0000162321206714 0.7995347366775002 0.8052634274410748 0.04647160177498005 7.99709393777544e-06 1.447380506889528e-06 0.044999576499924546 0.014998644978060001 7.253198416156047e-11 10.139470441956005 -0.20048149544317118 SPGLYFLTAGDQGTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPGLYFLTAGDQGTLR 16 0 Q12788;J3KNP2;A0A087WYP7 Q12788 TBL3 Transducin beta-like protein 3 0 3226900.0 0.0 1020800.0 2206100.0 False True 0.0 1015300.7477870635 2667385.3101460873 0.0 SPGMEK(ub)LNALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPGMEKLNALR 11 1 P43353-2;P43353;A0A087X2D4 P43353-2 ALDH3B1 Aldehyde dehydrogenase family 3 member B1 1 8440600.0 2210700.0 2455100.0 3774800.0 True False 2898249.108449257 2088808.6499048476 3384219.906438422 1.0 0.7207139799734088 1.167677373408799 21.466750171147595 -6.737750794544978 1.6949013462358065 0.8333947388362144 1.167814491914681 0.5948143553000002 0.11735194620503375 0.32190166334012754 1.8148083780362883 0.05479375203239221 0.13479389923893337 1.8291495117192805e-07 6.737750794544978 0.3344197530784665 SPGMEK(ub)LNALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPGMEKLNALR 11 1 P43353-2;P43353;A0A087X2D4 P43353-2 ALDH3B1 Aldehyde dehydrogenase family 3 member B1 1 8198100.0 2210700.0 3030200.0 2957200.0 True False 3028055.5319211595 2896315.744468602 2258770.2654457637 1.0 0.9564936025565638 0.7459474377646832 21.529960232670486 -6.940536099908884 0.6545580786511613 1.0023432576522018 0.6882632584685057 0.9982332613994296 0.004663008713139849 0.08752295593060347 0.053502489512837224 0.004557735794098169 0.01807891610125066 1.1467371970961749e-07 6.940536099908884 -0.3140799991836961 SPGMEK(ub)LNALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPGMEKLNALR 11 1 P43353-2;P43353;A0A087X2D4 P43353-2 ALDH3B1 Aldehyde dehydrogenase family 3 member B1 1 6480700.0 2071900.0 2295900.0 2112900.0 True False 1722876.6507328865 2283531.5309995296 2554697.621054199 1.0 1.3254178875940705 1.4828093583875943 20.716387984905513 -11.945880728827499 0.11777321069712081 4.370328855565511e-12 1.7745436796691247 0.9997719139827144 0.003036288059582781 5.435824309902698 0.0835999996959373 1.5750839433337578 0.21946365645874388 1.1327113993473768e-12 11.945880728827499 1.7745436796647545 SPGNK(ub)SDNIKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPGNKSDNIKPK 12 2 A0A1W2PRV5;E7EQZ4;Q16637-3;Q16637;Q16637-4;Q16637-2;B4DP61;A0A0G2JRX5;A0A0G2JRY6;H0YBZ9 A0A1W2PRV5 SMN1;SMN2 Survival motor neuron protein 1 1604980.0 659190.0 478430.0 467360.0 True False 902910.3569399312 457291.38064356 356979.19358133763 1.0 0.5064637670049261 0.39536504464427885 19.784223235102 -13.999999999999998 0.20952866439400092 3.848780513305795 0.32962818864631893 0.9994897523467919 0.005935962392285191 12.735724996041737 0.14508894324926994 14.932784434605608 0.06602751853356684 1.0000000000000041e-14 13.999999999999998 -3.519152324659476 SPGTRPEDEAEGK(ub)PPQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPGTRPEDEAEGKPPQR 17 2 A0A087WY96;P31641;A0A087WYN0;C9JPV1;P31641-2 A0A087WY96 SLC6A6 Transporter;Sodium- and chloride-dependent taurine transporter 1 12795700.0 2210100.0 1941900.0 8643700.0 True False 2139941.5852475753 2717310.796874723 6379655.664558323 1.0 1.2698060618137623 2.981228884254915 21.02913998472449 -6.934670327566808 0.7074145451914653 0.977930184921145 3.378359146310346 0.9973790359380618 0.04491411525407749 0.0902843860205456 0.06632681869403682 0.042121984708124637 0.15107600514310546 1.1623306028405483e-07 6.934670327566808 2.400428961389201 up SPIAEAVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPIAEAVFR 9 0 G5E9R5;P24666-4;P24666;F2Z2Q9;D3YTI2;P24666-3;P24666-2 G5E9R5 ACP1 Low molecular weight phosphotyrosine protein phosphatase 0 7789300.0 2375800.0 2753000.0 2660500.0 False True 3114696.8072799267 2342263.1311099525 2385216.9813180664 1.0 0.7520035740350142 0.7657942743393643 21.570660303705864 -10.373465436548079 8.660792845337562 1.0000009034686512 0.7588989241888039 0.9975522238102592 0.005630029823550422 9.821547946025764e-08 7.109372180032335e-09 0.005451273323328331 0.0018170843121051578 4.231891880103457e-11 10.373465436548079 -0.24110197927984733 SPIAEAVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPIAEAVFR 9 0 G5E9R5;P24666-4;P24666;F2Z2Q9;D3YTI2;P24666-3;P24666-2 G5E9R5 ACP1 Low molecular weight phosphotyrosine protein phosphatase 0 5893800.0 2376400.0 1374500.0 2142900.0 False True 2300962.4827755964 1923345.0179228098 1581610.20437799 1.0 0.8358871699649463 0.6873689667769511 21.133806029915792 -6.972313319162118 0.19518720252694538 1.0940825000596914 0.42509421579881784 0.9999952485015953 0.00027826483257664745 0.07555898494527709 0.006265472069439527 0.005018435976415787 0.015964434390048028 1.0658269093290284e-07 6.972313319162118 -0.6689882842608736 SPIAEAVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPIAEAVFR 9 0 G5E9R5;P24666-4;P24666;F2Z2Q9;D3YTI2;P24666-3;P24666-2 G5E9R5 ACP1 Low molecular weight phosphotyrosine protein phosphatase 0 7412500.0 2375800.0 2877200.0 2159500.0 False True 3254197.4635808934 2750075.7903719433 1649470.5762985686 1.0 0.8450857150339554 0.5068747655169961 21.633870365228756 -6.958295012720903 0.45883184724016174 1.0099740849500836 0.32837914510251665 0.9997016414226976 0.0035565382123336573 0.0803158876064973 0.02342493433976899 0.00458423829045212 0.027943258500392466 1.1007912969064104e-07 6.958295012720903 -0.6815949398475669 SPIAEAVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPIAEAVFR 9 0 G5E9R5;P24666-4;P24666;F2Z2Q9;D3YTI2;P24666-3;P24666-2 G5E9R5 ACP1 Low molecular weight phosphotyrosine protein phosphatase 0 4362780.0 2376400.0 1042800.0 943580.0 False True 1976081.8923701122 1037182.2294204069 1140878.2153790148 1.0 0.5248680398444473 0.5773435907611327 20.91421130535007 -10.387921302699722 5.179388827433146 1.0003033544799218 0.5511058153027675 0.9898548409223648 0.02142305395296482 7.509302250306287e-05 8.874171017183296e-06 0.020756525429546296 0.006914260932050005 4.093348274403646e-11 10.387921302699722 -0.4491975391771543 SPIIFIGTGEHIDDFEPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPIIFIGTGEHIDDFEPFK 19 0 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 0 11515900.0 5561200.0 1979400.0 3975300.0 False True 5384662.750046971 2769784.742434638 2934049.6735563134 1.0 0.5143840702763561 0.5448901462827397 22.360424558648695 -10.001819712718971 5.126960647357002 1.0000035875831008 0.5296371082765401 0.9968551494859297 0.012454053388840695 17169653.390843343 3.1643186275067117 727.1717132448284 0.004263353731805244 9.958187226039709e-11 10.001819712718971 -0.4703664793065607 SPIIFIGTGEHIDDFEPFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPIIFIGTGEHIDDFEPFK 19 0 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 0 32686800.0 6362700.0 19488000.0 6836100.0 False True 9652681.0756778 16010214.13956101 5484941.838630932 1.0 1.6586287285407688 0.5682298830375254 23.202498282415895 -6.743166576617064 1.675021457214245 1.3904406365638513 0.5671313039332577 0.6190813339408929 0.2767174756806231 0.31212985486096595 1.7206708959185075 0.13062637946011657 0.31944809559207793 1.8064811049373126e-07 6.743166576617064 -0.8233093326305936 SPIIFIGTGEHIDDFEPFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPIIFIGTGEHIDDFEPFK 19 0 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 0 23024300.0 6362700.0 7510200.0 9151400.0 False True 8236640.57756764 7092250.768003614 7485939.101293507 1.0 0.861061096597956 0.9088582937176285 22.973624604508345 -10.182327356315236 6.909581435293034 1.0000002576762606 0.8849596959354847 0.8853717238740445 0.019513124013070614 7.746010477692788e-08 9.167803350304661e-09 0.018893543595344616 0.006297833694591876 6.57162304169663e-11 10.182327356315236 -0.11504056174077582 SPILLGSLAHQIYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPILLGSLAHQIYR 14 0 P31937 P31937 HIBADH 3-hydroxyisobutyrate dehydrogenase, mitochondrial 0 4477800.0 1178300.0 1842200.0 1457300.0 False True 1613949.3523602001 1760805.5126592498 1113115.75403561 1.0 1.0909918022423013 0.6896844392346121 20.62216387517329 -6.847111642960499 1.248871757373583 1.0484639729096035 0.6745073078780826 0.9360041150168561 0.043459776284592334 0.16066552332895104 0.48365832954210336 0.02724871161407172 0.06295258454210692 1.4219631997282997e-07 6.847111642960499 -0.3739566650315209 SPILVATAVAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPILVATAVAAR 12 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 35456300.0 9833300.0 14532000.0 11091000.0 False True 12891551.525812665 12363882.245292325 9943409.712384375 1.0 0.9590685977972634 0.7713121025405479 23.61992256979578 -6.941744800902613 0.6431276537429348 1.0020604698148876 0.7179710538019272 0.9983836036845576 0.004003114561575051 0.0869796254725498 0.05105217522614631 0.003950314763110833 0.01603969984564348 1.1435501076101337e-07 6.941744800902613 -0.28408941601296045 SPILVATAVAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPILVATAVAAR 12 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 23568300.0 8162300.0 4405000.0 11001000.0 False True 7903192.25431713 6163939.471771526 8119508.077074185 1.0 0.7799303462982905 1.027370689690472 22.914004073149567 -6.672096280922726 1.9300425599456197 0.8597837415763501 1.026378058016052 0.2883345814269205 0.09343596130076995 0.4563144304830275 3.279059236532489 0.03894713799809052 0.10376956980343861 2.127667300453615e-07 6.672096280922726 0.1665943164397019 SPILVATAVAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPILVATAVAAR 12 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 86860000.0 11606000.0 54870000.0 20384000.0 False True 17607150.51225371 45078019.798733205 16355093.465375412 1.0 2.56021096470784 0.9288892858610525 24.06965811088924 -6.656263210433692 1.9860798661622021 2.0073431151084526 0.9357089682922975 0.2199276769874312 0.6648958735092649 0.49332674837869556 3.736689870173027 0.2708439714197349 0.7368377055531186 2.2066669453426572e-07 6.656263210433692 -1.0716341468161552 SPILVATAVAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPILVATAVAAR 12 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 36035300.0 9833300.0 13631000.0 12571000.0 False True 13468936.74494066 13028737.348310856 9601988.70787187 1.0 0.9673174352982868 0.7128987899864231 23.68313263131867 -6.9306075419810655 0.7417872058116903 1.0037830472483122 0.6598504111294898 0.9966563117899682 0.007420803213481912 0.09232363912981378 0.07614347328029905 0.006785296690223567 0.022944084867542933 1.1732551197318438e-07 6.9306075419810655 -0.3439326361188224 SPILVATAVAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPILVATAVAAR 12 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 18193700.0 8162300.0 6795500.0 3235900.0 False True 6787314.101200364 6758891.292698866 3912511.728888861 1.0 0.9958123628761382 0.5764447719012912 22.694409348583843 -6.909084514473575 0.9019480662522229 1.0133633879352428 0.5232968326313266 0.990571445293356 0.019292574207067755 0.10502648213058513 0.14207465670406966 0.015723938600230344 0.043134663430724855 1.2328648921967033e-07 6.909084514473575 -0.4900665553039162 SPIQK(ub)NEGCNHMQCAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPIQKNEGCNHMQCAK 16 1 Q9P2G1 Q9P2G1 ANKIB1 Ankyrin repeat and IBR domain-containing protein 1 1 4328600.0 440980.0 927820.0 2959800.0 True False 578129.0504563943 789392.8726140333 2653548.288406392 1.0 1.3654267537513645 4.589889206071884 19.141032042720273 -6.928319807721988 0.7604590542816135 0.9477872266606181 5.224390401776399 0.9961975604142407 0.09946832403405986 0.09351973295722728 0.08202390840915372 0.08973069846149642 0.2944999843855585 1.179451785781592e-07 6.928319807721988 4.276603175115781 up SPIQK(ub)NEGCNHMQCAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPIQKNEGCNHMQCAK 16 1 Q9P2G1 Q9P2G1 ANKIB1 Ankyrin repeat and IBR domain-containing protein 1 1 22174840.0 875440.0 8117100.0 13182300.0 True False 1328106.4832368935 6668540.08580824 10576812.626992652 1.0 5.021088421732203 7.963828774643571 20.340939391219216 -8.019461626702059 0.3066537187858312 1.7359191655522525e-18 9.757328553339718 0.9989830247308722 0.09102409616943992 0.10275335232095711 0.06397269494020077 0.5469009561734258 0.8274938206713526 9.561771769837254e-09 8.019461626702059 9.757328553339718 SPIQK(ub)NEGCNHMQCAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPIQKNEGCNHMQCAK 16 1 Q9P2G1 Q9P2G1 ANKIB1 Ankyrin repeat and IBR domain-containing protein 1 1 11237210.0 875440.0 4881170.0 5480600.0 True False 1133274.3375022903 4609528.598606728 4483187.035704839 1.0 4.067442847745074 3.9559591948280386 20.112065713311665 -10.219657237322455 4.277952066777351 0.9986199038636031 4.011701021406492 0.9989733702195115 0.04551301112585874 10685440.421832288 7172643.520972167 162258.81994222384 0.016656056896152585 6.03035338058322e-11 10.219657237322455 3.013081117542889 SPISVPGGSALISNLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPISVPGGSALISNLGK 17 0 A6NEM2;P51610-2;P51610;P51610-4 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 9110400.0 1570400.0 4179200.0 3360800.0 False True 2058809.6077752314 3555679.6503940118 3013056.6550700045 1.0 1.7270560798656422 1.463494557093087 20.973378989571767 -10.413383766351163 5.570728263769306 0.9996787536197411 1.595275318479367 0.8718210062940177 0.10759854110395685 0.0004295217797741761 4.523008294788484e-05 0.10423627368444756 0.03472727981431868 3.860257128688901e-11 10.413383766351163 0.595596564859626 SPISVPGGSALISNLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPISVPGGSALISNLGK 17 0 A6NEM2;P51610-2;P51610;P51610-4 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 6436300.0 2417400.0 1230500.0 2788400.0 False True 2340660.960217858 1721845.0669727297 2058034.3897930798 1.0 0.7356234398049977 0.8792535205959633 21.158484547586383 -10.076773401467126 4.775090062828869 1.0000075175988492 0.8074384803701165 0.7055838165738897 0.05863673495162032 14935005.21302236 31517031.55355412 730.7938696424129 0.020072915361775707 8.379663874410977e-11 10.076773401467126 -0.19256903722873275 SPISVPGGSALISNLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPISVPGGSALISNLGK 17 0 A6NEM2;P51610-2;P51610;P51610-4 A6NEM2 HCFC1 Host cell factor 1;HCF N-terminal chain 1;HCF N-terminal chain 2;HCF N-terminal chain 3;HCF N-terminal chain 4;HCF N-terminal chain 5;HCF N-terminal chain 6;HCF C-terminal chain 1;HCF C-terminal chain 2;HCF C-terminal chain 3;HCF C-terminal chain 4;HCF C-terminal chain 5;HCF C-terminal chain 6 0 5676600.0 1570400.0 2122300.0 1983900.0 False True 2151019.3184642782 2028529.7684924162 1515343.679703047 1.0 0.9430551139543862 0.7044770201250111 21.03658905109466 -6.943811931720493 0.6230942306591372 1.0026064936855574 0.6322189870651176 0.9986217396019652 0.0047526329166070235 0.08606990940180123 0.04700843979329681 0.004772839883320171 0.02021473915313879 1.1381200342858586e-07 6.943811931720493 -0.37038750662043984 SPITGNDLSPPVSFNLMFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPITGNDLSPPVSFNLMFK 19 0 P41250 P41250 GARS Glycine--tRNA ligase 0 28249000.0 13745000.0 5389700.0 9114300.0 False True 13308672.498632615 7541835.316914201 6726991.406860944 1.0 0.5666857695753711 0.5054592340109129 23.665863338004307 -13.999999999999998 0.2756636905976864 4.448541130220724 0.4862259319167511 0.9995956262634086 0.004426425612695361 15.168667979319116 0.16626423548932884 29.414641902468198 0.02472922388314524 1.0000000000000041e-14 13.999999999999998 -3.9623151983039726 SPITGNDLSPPVSFNLMFK ddPTM_RPMI8226_Bortezomib_8h_R1 2 SPITGNDLSPPVSFNLMFK 19 0 P41250 P41250 GARS Glycine--tRNA ligase 0 101533400.0 28760900.0 47681500.0 25091000.0 False True 43632388.003435954 39172363.78774012 20131752.852224022 1.0 0.8977817988017384 0.4613947063965119 25.378896098880247 -6.943381185828112 0.6273203199313887 1.0047612066741556 0.33100424101194825 0.9985740665187155 0.008819810727243171 0.08625744181885606 0.0478357481936849 0.008823824984183003 0.03703611805683652 1.1392494148054026e-07 6.943381185828112 -0.6737569656622073 down SPITGNDLSPPVSFNLMFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPITGNDLSPPVSFNLMFK 19 0 P41250 P41250 GARS Glycine--tRNA ligase 0 4246540.0 1528900.0 723340.0 1994300.0 False True 2094175.6469689482 691380.4470344924 1523287.4138977698 1.0 0.33014444038406104 0.727392382822584 20.997951021327232 -10.801051921004381 6.941199824578652 1.0196018031767338 0.5287684116037079 0.6523216858847164 0.16217579339081406 0.046661939006329776 0.001337419078802175 0.1489415979548954 0.0523420122467165 1.5810590083654077e-11 10.801051921004381 -0.49083339157302586 SPITGNDLSPPVSFNLMFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPITGNDLSPPVSFNLMFK 19 0 P41250 P41250 GARS Glycine--tRNA ligase 0 25373100.0 13745000.0 5587400.0 6040700.0 False True 11429576.506744305 5557299.567187941 7303782.440958921 1.0 0.4862209517481876 0.6390247649726255 23.446268613438583 -10.783067693559305 10.604053787525238 1.0021902527600957 0.5626228583604224 0.9161356702501608 0.06238189552523621 0.003237099594988386 6.62227371824094e-05 0.060530375476390993 0.020133670206174226 1.6479055121764048e-11 10.783067693559305 -0.4395673943996733 SPITGNDLSPPVSFNLMFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPITGNDLSPPVSFNLMFK 19 0 P41250 P41250 GARS Glycine--tRNA ligase 0 59570000.0 23213000.0 21492000.0 14865000.0 False True 30049686.096637867 20295951.307013642 12159722.527780233 1.0 0.6754130889002687 0.4046538951746565 24.840846584625893 -7.388475506649709 0.2027991320794933 1.184957453016196 7.550716348385897e-14 0.9999656299993288 0.001426825977187028 0.11861022917853169 0.015261690962332921 0.024236976007442654 0.05540329105261882 4.0881280769520496e-08 7.388475506649709 -1.1849574530161204 down SPK(ub)DPSQLNSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPKDPSQLNSK 11 1 Q9NXG2 Q9NXG2 THUMPD1 THUMP domain-containing protein 1 1 2370920.0 913500.0 965740.0 491680.0 True False 1197607.346346584 821655.3564250367 440805.670127595 1.0 0.6860807583817644 0.36807194901761 20.191723545620448 -7.157019389421162 0.2561418287882299 1.1035002299035797 1.1573492355933043e-12 0.9999709487908522 0.0013905077163151821 0.08377808956752872 0.011565636276563202 0.009751061990812474 0.0353016948319926 6.965954133624918e-08 7.157019389421162 -1.1035002299024224 down SPK(ub)DPSQLNSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPKDPSQLNSK 11 1 Q9NXG2 Q9NXG2 THUMPD1 THUMP domain-containing protein 1 1 2830360.0 1075600.0 1165700.0 589060.0 True False 1041455.6667536722 1631170.0890451944 434767.5145787948 1.0 1.5662405430369635 0.4174613749368817 19.9901699965895 -6.772682294415312 1.5642580982813608 1.323664341965078 0.4103445486692974 0.7407016102458142 0.23882259045799212 0.2621074513370684 1.2660965472470445 0.12031758030256427 0.28569847256625885 1.6877872647720202e-07 6.772682294415312 -0.9133197932957806 down SPK(ub)DPSQLNSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPKDPSQLNSK 11 1 Q9NXG2 Q9NXG2 THUMPD1 THUMP domain-containing protein 1 1 2160190.0 913500.0 780850.0 465840.0 True False 1251245.6364092713 746349.4650743542 355818.18627595523 1.0 0.5964851691440625 0.2843711705537331 20.25493360714334 -7.874941666318702 0.25280864267575426 1.1614472240255467 2.2446685957415566e-10 0.9996647703123347 0.005363653799067033 0.11497692047927108 0.04100538794059931 0.05487258145572815 0.0896684907719681 1.3337005604782332e-08 7.874941666318702 -1.1614472238010798 down SPK(ub)GAAPDSHQLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPKGAAPDSHQLAK 14 1 F5H0R1;Q9H6E5;C9JBX0;H3BRB1 F5H0R1 TUT1 Speckle targeted PIP5K1A-regulated poly(A) polymerase 1 2602060.0 633050.0 690010.0 1279000.0 True False 612954.1742640503 965534.5913546146 943991.5308224609 1.0 1.5752149702119143 1.5400686877707848 19.225419693486156 -10.141629119921102 4.821131443548926 0.9999594470364562 1.557641828994465 0.9970295825856299 0.014348409733521722 6.254929908315427e-06 1.1135920873397686e-06 0.013893795404504122 0.004630929327009022 7.217235556906917e-11 10.141629119921102 0.5576823819580087 SPK(ub)GAAPDSHQLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPKGAAPDSHQLAK 14 1 F5H0R1;Q9H6E5;C9JBX0;H3BRB1 F5H0R1 TUT1 Speckle targeted PIP5K1A-regulated poly(A) polymerase 1 4295880.0 386300.0 724480.0 3185100.0 True False 586045.3423129073 595190.8836119245 2555563.588921076 1.0 1.0156055182742738 4.360692602444716 19.160652764680453 -6.907923446337225 0.9097588563157365 0.889505772016033 4.774325517149736 0.9901141020585239 0.15715370252141417 0.10580721088863305 0.14633396601317192 0.1273572313202478 0.3467057471708476 1.2361653147359627e-07 6.907923446337225 3.8848197451337025 up SPK(ub)GAAPDSHQLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPKGAAPDSHQLAK 14 1 F5H0R1;Q9H6E5;C9JBX0;H3BRB1 F5H0R1 TUT1 Speckle targeted PIP5K1A-regulated poly(A) polymerase 1 3200750.0 386300.0 636950.0 2177500.0 True False 500072.96511141193 601503.1725759514 1781217.3430367643 1.0 1.2028308157829362 3.561914895039216 18.931779086772902 -6.923849986098387 0.7956560352544166 0.9548107530964446 3.97819202532298 0.9951852088625652 0.08068813067651659 0.09595898857910028 0.09426275543410248 0.07097837842536593 0.2211114238275885 1.1916535576466828e-07 6.923849986098387 3.0233812722265356 up SPLAGDFITMQCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPLAGDFITMQCR 13 0 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 0 10162900.0 1799500.0 4193800.0 4169600.0 False True 2359161.9263827913 3568101.3873043656 3738169.7896274356 1.0 1.5124444606374234 1.5845329427467585 21.16984301391769 -11.681022239721862 0.3268898353278744 2.2008949737323674e-10 1.5993579744561015 0.9994868264937347 0.005895064211726717 4.3619181952216435 0.17250139231074127 3.0519803993151884 0.023343678017010122 2.084384141445175e-12 11.681022239721862 1.599357974236012 SPLAGDFITMQCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPLAGDFITMQCR 13 0 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 0 11027200.0 1799500.0 4455600.0 4772100.0 False True 2464823.7796589886 4258736.8593011405 3645028.264484553 1.0 1.727805814941603 1.478819011146041 21.23305307544058 -10.322184720958102 5.3416861656831225 0.9998555006937646 1.6033124130438496 0.8867286343869785 0.10164843699769648 0.0001749640020761349 2.220181525680687e-05 0.09844393388208354 0.032806891971660306 4.7622838677604305e-11 10.322184720958102 0.603456912350085 SPLIIFSDCDMNNAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPLIIFSDCDMNNAVK 16 0 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 6239600.0 1256600.0 2663600.0 2319400.0 False True 1647414.7689317095 2266201.262631482 2079410.7372558245 1.0 1.3756106266432429 1.2622265967690998 20.6517723968517 -10.071063753046207 4.26056500766634 0.999967262147542 1.3189186116952476 0.9134093909626734 0.0462888365782334 10709572.650113134 0.277598385330666 3692.660028393239 0.01584589993950487 8.490558271973886e-11 10.071063753046207 0.31895134954770565 SPLIIFSDCDMNNAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPLIIFSDCDMNNAVK 16 0 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 7370900.0 1256600.0 2475300.0 3639000.0 False True 1721198.9783381384 2365933.0612775213 2779543.1475575287 1.0 1.3745842816859501 1.6148877512356232 20.714982458374593 -8.991051308721293 0.08729436547355854 1.4754484370245707e-19 2.4980965067097176 0.9999787977039563 0.0011650140644107558 0.47552113875826585 0.028072084132478897 0.4457469777697364 0.33519226569807 1.0208188742885176e-09 8.991051308721293 2.4980965067097176 SPLLAGGSPPQPVVPAHKDK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPLLAGGSPPQPVVPAHKDK 20 1 Q8NFH5-2;Q8NFH5;C9IYQ7;F8WCF5;F8WEL4;C9JIY9 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 4469000.0 1438200.0 1788800.0 1242000.0 True False 1885494.1275486122 1521918.012687787 1113489.7541052562 1.0 0.807171971766615 0.590555938539537 20.846511226475887 -6.9696171910902995 0.2671718077766254 1.0557292366063653 0.3355110441007726 0.9999792396978022 0.0007620219923517369 0.07642711561862439 0.009473754558530716 0.0043209142480705705 0.02022600364065953 1.072464212407586e-07 6.9696171910902995 -0.7202181925055927 SPLLAGGSPPQPVVPAHKDK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPLLAGGSPPQPVVPAHKDK 20 1 Q8NFH5-2;Q8NFH5;C9IYQ7;F8WCF5;F8WEL4;C9JIY9 Q8NFH5-2 NUP35 Nucleoporin NUP53 1 10563400.0 3453800.0 2531900.0 4577700.0 True False 4471012.18457622 2390997.539281024 3744605.5711684898 1.0 0.5347776835700242 0.8375297173392557 22.092170046898698 -10.138369513937148 5.263123963288987 1.0000091590188684 0.686153700454436 0.5889582768792174 0.1235980002214596 1.3283790916198796e-05 2.1743576613027676e-06 0.11967674110857619 0.039891083040085 7.271608456990372e-11 10.138369513937148 -0.3138554585644324 SPLSWIEEK(ub)GPGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPLSWIEEKGPGLK 14 1 P53004 P53004 BLVRA Biliverdin reductase A 1 8091800.0 2487400.0 2656400.0 2948000.0 True False 2408438.8485339195 3717114.3729429995 2175830.361895709 1.0 1.5433708749573216 0.9034193926992145 21.19966686296596 -6.681751347699682 1.8957294215448903 1.3432592268927428 0.9058257721322163 0.33210534488802435 0.23020651167453549 0.4346581586577007 3.021618537627684 0.0973877249826182 0.2562726744503921 2.080887743983654e-07 6.681751347699682 -0.43743345476052653 SPLSWIEEK(ub)GPGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPLSWIEEKGPGLK 14 1 P53004 P53004 BLVRA Biliverdin reductase A 1 8146300.0 2487400.0 2955600.0 2703300.0 True False 2068383.310503874 2939677.5961593315 3268547.5313530304 1.0 1.4212441094601578 1.5802426536485576 20.980072138400235 -11.77034011886989 0.16773463561766233 7.06261696248801e-19 1.7437958423555537 0.9995187970381677 0.005370337788607316 4.79572892320809 0.1076464139789207 1.83629816668241 0.12994046159066902 1.6969141891168524e-12 11.77034011886989 1.7437958423555537 SPLVAAMQHFLPVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPLVAAMQHFLPVLK 15 0 O95373;E9PLB2 O95373 IPO7 Importin-7 0 222271000.0 69390000.0 60012000.0 92869000.0 False True 67187252.43216565 83975104.55844562 68543822.88971932 1.0 1.2498666267567573 1.020190890510418 26.0016841978487 -10.813160226181477 2.9471931028566 0.9620030902134259 1.135028758684849 0.3154677426442225 0.09376472705031956 25682824.26131034 9670228.271216612 6692142.9296465805 0.03431437685237404 1.5375872667858396e-11 10.813160226181477 0.1730256684714232 SPLVAAMQHFLPVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPLVAAMQHFLPVLK 15 0 O95373;E9PLB2 O95373 IPO7 Importin-7 0 21885700.0 5043600.0 7715700.0 9126400.0 False True 7651509.936550293 6338773.051960739 7322563.039756778 1.0 0.8284342704282751 0.9570088911180553 22.86731304432165 -10.386921896626376 5.19443593266506 1.000070131699365 0.8927215807867239 0.48138814960662735 0.0524903690936599 4.266002123353763e-05 5.0349472868924005e-06 0.050856771542856734 0.016941193777999575 4.10277880588456e-11 10.386921896626376 -0.10734855091264106 SPLVAAMQHFLPVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPLVAAMQHFLPVLK 15 0 O95373;E9PLB2 O95373 IPO7 Importin-7 0 166603000.0 69390000.0 32340000.0 64873000.0 False True 57700859.49821659 32165778.001012627 78437644.36113833 1.0 0.5574575193634126 1.3593843322829995 25.782089473282976 -6.756888107129993 1.624105665485951 0.7419545044230604 1.3618793800637077 0.678160164958701 0.18606126231440687 0.2881804299175083 1.497403046802528 0.09042105142701184 0.2179757605694252 1.7502975822026954e-07 6.756888107129993 0.6199248756406472 SPLVAAMQHFLPVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPLVAAMQHFLPVLK 15 0 O95373;E9PLB2 O95373 IPO7 Importin-7 0 15034200.0 5043600.0 6279900.0 3710700.0 False True 6529039.624219301 5930418.044524237 3035390.6749972543 1.0 0.9083139919270066 0.4649061500159307 22.6384393664141 -6.940551266800517 0.6544156059537589 1.004933760738907 0.34336906799961314 0.9982352083941508 0.009815613459554425 0.08751605788248934 0.05347127711936518 0.00959514661535913 0.03807148617461723 1.1466971502251464e-07 6.940551266800517 -0.661564692739294 down SPNELVDDLFK(ub)GAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPNELVDDLFKGAK 14 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 40035800.0 11563000.0 19574000.0 8898800.0 True False 15159204.976251274 16653635.498854412 7978037.539317121 1.0 1.0985823811304316 0.5262833738191205 23.85369075763507 -6.862509964342048 1.173068069570474 1.0538810578623987 0.4972220915054814 0.9566144493320692 0.052033733241304135 0.14423393635456985 0.37574385356877144 0.03456081475005494 0.08091264706568171 1.3724294719738562e-07 6.862509964342048 -0.5566589663569173 SPNELVDDLFK(ub)GAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPNELVDDLFKGAK 14 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 63069000.0 27239000.0 23337000.0 12493000.0 True False 26374312.85487476 32655585.800847296 9220708.51803362 1.0 1.2381587334819064 0.34960943129668526 24.652630171158243 -6.835360644891559 1.3036570374698586 1.1268675693813133 0.3229488627603965 0.9161993982116147 0.10871148889045155 0.1742862050323909 0.5773511503633422 0.06543221601954524 0.150615961281714 1.460963463804332e-07 6.835360644891559 -0.8039187066209168 down SPNELVDDLFK(ub)GAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPNELVDDLFKGAK 14 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 54302000.0 24599000.0 19600000.0 10103000.0 True False 37318481.427789815 16102226.864501031 8106137.621697795 1.0 0.431481299571591 0.21721509856672322 25.153386945117948 -11.977833122409388 0.16604053357889756 2.4525498343350436 3.585219990169487e-11 0.9995251884410373 0.0071972652309800255 5.302887680421818 0.10951261652305427 2.8422307145474135 0.17634278271592718 1.0523661676880276e-12 11.977833122409388 -2.4525498342991914 SPNELVDDLFK(ub)GAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPNELVDDLFKGAK 14 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 30588100.0 11563000.0 13662000.0 5363100.0 True False 15838153.578325555 13058367.665807577 4096446.2365116235 1.0 0.8244880062078636 0.258644179465313 23.916900819157963 -6.9498216772552555 0.5607970272742686 1.0073698314245971 0.04868270723655897 0.9991872212037002 0.009018388023970201 0.08355741577659757 0.03625918724666641 0.009657917711170142 0.0470451551969843 1.1224792533713274e-07 6.9498216772552555 -0.9586871241880381 down SPNELVDDLFK(ub)GAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPNELVDDLFKGAK 14 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 66830900.0 27239000.0 30007000.0 9584900.0 True False 22650435.392303232 29845346.33507687 11589058.274429642 1.0 1.3176500061989322 0.5116483667403444 24.43303544659252 -6.799804157266218 1.4568805817173034 1.1753025892886009 0.5005947818724595 0.8315552050203525 0.13605412812553128 0.2210301042461825 0.9262384260089451 0.07347113336551495 0.17087434669039947 1.5856080525924787e-07 6.799804157266218 -0.6747078074161413 SPNELVDDLFK(ub)GAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPNELVDDLFKGAK 14 1 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 68741200.0 24599000.0 35776000.0 8366200.0 True False 31843890.418782342 33785034.15036847 6843637.444461156 1.0 1.0609581211986958 0.21491210258733345 24.924513267210397 -6.889579861658803 1.02482642688077 1.0459177500967602 0.1427300471076426 0.9806293940764443 0.05362075116241664 0.11948623798798605 0.22382511503544142 0.039886991733385335 0.09929334779185921 1.2894964128371612e-07 6.889579861658803 -0.9031877029891177 down SPNLSK(ub)CGEELGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPNLSKCGEELGR 13 1 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 84721300.0 35523800.0 30253200.0 18944300.0 True False 46572045.81296852 25739540.48604994 16984125.562557332 1.0 0.5526821945812496 0.36468497928488913 25.47296092234996 -13.99999999999964 0.11871647482383633 3.134167713840606 0.059374446642749656 0.9996992626347299 0.004621078830249303 11.968863851016676 0.10587148483541729 6.036974823155912 0.27091303788999693 1.0000000000008304e-14 13.99999999999964 -3.0747932671978564 SPNLSK(ub)CGEELGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPNLSKCGEELGR 13 1 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 44403200.0 17367000.0 17910000.0 9126200.0 True False 16815694.09121516 25061556.399416186 6735774.4398685945 1.0 1.4903670501777755 0.40056475833415 24.003304993554025 -6.784376591011272 1.5187459161277925 1.2760795197715549 0.39070560613005445 0.7825957087282205 0.20779253107394405 0.2438319927123594 1.1110851615771002 0.10773102668349924 0.25329403671969625 1.6429464525170694e-07 6.784376591011272 -0.8853739136415004 down SPNLSK(ub)CGEELGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPNLSKCGEELGR 13 1 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 127222000.0 53367800.0 50744300.0 23109900.0 True False 80962854.30879307 41688583.19797445 18542218.135570984 1.0 0.5149099985898943 0.229021299877235 26.27075681670118 -8.653993998546389 0.23921794472860333 1.2738616358511514 3.5966847009571335e-22 0.9993830510741574 0.007904425866203673 0.2379131749507183 0.06801650556798002 0.16574258978924872 0.11576905616330073 2.2182270729525175e-09 8.653993998546389 -1.2738616358511514 down SPNLSK(ub)CGEELGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPNLSKCGEELGR 13 1 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 85525300.0 35523800.0 25238900.0 24762600.0 True False 48657908.854598396 24123761.944118783 18914183.88175547 1.0 0.49578295722092003 0.38871756569472865 25.53617098387285 -13.999999999999998 0.21778771620211046 4.013487166713525 0.3302197756667204 0.9994957751519099 0.005985008451495604 12.940386487850962 0.1478579137183835 16.75160185347615 0.06012925255948273 1.0000000000000041e-14 13.999999999999998 -3.683267391046805 SPNLSK(ub)CGEELGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPNLSKCGEELGR 13 1 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 39911200.0 17367000.0 21507000.0 1037200.0 True False 14441429.988550609 21391137.522194754 1254073.7245290438 1.0 1.481234028704497 0.08683861124025065 23.7837102689883 -6.81351111210073 1.3996591316427713 1.2612009158673336 0.06041913583660104 0.868816319916665 0.20945302588317147 0.202048436451067 0.7794262789867399 0.11764328578660001 0.27173461544770416 1.5363454830366633e-07 6.81351111210073 -1.2007817800307325 down SPNLSK(ub)CGEELGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPNLSKCGEELGR 13 1 R4GMR5;P48556;K7EJR3;K7ENY6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 1 112018300.0 53367800.0 47438500.0 11212000.0 True False 69085669.13661091 44798505.77320708 9171531.04483499 1.0 0.6484486049432615 0.13275591247005344 26.04188313879363 -7.456457920896793 0.4966773243040164 1.0139864251528417 1.932940468274471e-15 0.9975089150624995 0.017776142005669678 0.1138321585514219 0.06440700155962288 0.020136705923769323 0.06625074739239872 3.4957637866331965e-08 7.456457920896793 -1.0139864251528397 down SPNLWLK(ub)DVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPNLWLKDVLK 11 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 5748630.0 692630.0 2431900.0 2624100.0 True False 908044.6374384618 2069069.9994719564 2352583.304144607 1.0 2.2785994368169784 2.5908234101586682 19.792403693349748 -10.28859320216163 0.31435193036102776 1.0482861391809622e-16 2.6803440226559037 0.9989948659160116 0.02181973075472237 1.7557476878880298 0.1472677019758975 1.5767624338951964 0.1052774877047642 5.145253749791785e-11 10.28859320216163 2.6803440226559037 SPNLWLK(ub)DVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPNLWLKDVLK 11 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 18279100.0 1114800.0 4739300.0 12425000.0 True False 1691233.1027968659 3893534.8866800903 9969193.303929048 1.0 2.302187013866499 5.894629952218034 20.68964408955233 -6.95331856375892 0.5211411003459863 0.9394888486767858 7.417958932055772 0.9994366297687606 0.049128907280388344 0.08217994147924122 0.030654697690753376 0.055556213672504844 0.296771530619852 1.1134774757852471e-07 6.95331856375892 6.478470083378986 SPNLWLK(ub)DVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPNLWLKDVLK 11 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 5237530.0 692630.0 2227300.0 2317600.0 True False 948714.028621953 2128890.5213038507 1770230.6124702743 1.0 2.2439749567065577 1.8659264636801132 19.85561375487264 -10.081360324917005 4.911420664433508 0.999970776443041 2.0549507101905324 0.9121469655420069 0.1543376510276332 53617037.61747282 1.3517573698730185 19684.766943331873 0.052833883081905064 8.291625434818667e-11 10.081360324917005 1.0549799337474914 SPNLWLK(ub)DVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPNLWLKDVLK 11 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 11651200.0 1114800.0 1880300.0 8656100.0 True False 1443130.575993275 1775659.6520834607 7080778.619086345 1.0 1.2304220294558676 4.906540500822526 20.46077041164478 -6.919690938696284 0.8270219380172595 0.9179818195745983 5.495141998883034 0.9940945147039932 0.13753517929139109 0.09835391174527483 0.10656110085656773 0.11830706552625865 0.3533423321815801 1.203120318524931e-07 6.919690938696284 4.577160179308436 up SPPESENK(ub)EQLEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPPESENKEQLEAR 14 1 Q14534 Q14534 SQLE Squalene monooxygenase 1 16168300.0 6952500.0 7254000.0 1961800.0 True False 9114794.82810578 6171731.475870542 1758811.7549144065 1.0 0.6771113988040409 0.1929622978995699 23.11977875122701 -7.318461640182864 0.4456871448965348 1.0209363966319733 3.582401256788901e-12 0.9990692965588897 0.010118001721422992 0.10311664060798531 0.040549407315923755 0.01328295877676803 0.05534699220368742 4.8032850421847656e-08 7.318461640182864 -1.0209363966283909 down SPPESENK(ub)EQLEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPPESENKEQLEAR 14 1 Q14534 Q14534 SQLE Squalene monooxygenase 1 11800100.0 4257100.0 3354200.0 4188800.0 True False 4121960.690718722 4693549.551921922 3091627.618693605 1.0 1.1386691684106127 0.7500381130889766 21.974899315934586 -6.810215494299107 1.4134956380269066 1.0755549891069276 0.7431970224815295 0.860419175192281 0.06008015424081414 0.20650806042809322 0.8131326371475163 0.03342022026507518 0.07730505621304784 1.548048296094205e-07 6.810215494299107 -0.33235796662539807 SPPESENK(ub)EQLEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPPESENKEQLEAR 14 1 Q14534 Q14534 SQLE Squalene monooxygenase 1 12828800.0 5340200.0 3376800.0 4111800.0 True False 8101473.820914808 2774183.656941181 3299100.9277340383 1.0 0.3424295033552209 0.40722231542822024 22.949752956421094 -10.160883315187975 5.196796630151779 1.0000249485495456 0.37482590940359517 0.9920084983370102 0.026451554797869734 8.35003134815878e-06 1.3482566551118095e-06 0.02561272113209165 0.008537202595900678 6.904252801144455e-11 10.160883315187975 -0.6251990391459504 SPPESENK(ub)EQLEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPPESENKEQLEAR 14 1 Q14534 Q14534 SQLE Squalene monooxygenase 1 12295600.0 6952500.0 3166200.0 2176900.0 True False 9523027.134247908 3026306.8147767424 1662761.0546628172 1.0 0.31778832214949354 0.17460425463695117 23.1829888127499 -13.999999999999929 0.21943457156564475 5.106583179169117 0.09759859463013773 0.9994973321954539 0.008074031316957562 12.984293521862565 0.1484027528030091 23.09849942294366 0.07953807116756881 1.0000000000001636e-14 13.999999999999929 -5.00898458453898 SPPESENK(ub)EQLEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPPESENKEQLEAR 14 1 Q14534 Q14534 SQLE Squalene monooxygenase 1 12773700.0 4257100.0 6960100.0 1556500.0 True False 3539967.2715068115 6922604.559828319 1881956.9535571283 1.0 1.9555560910261367 0.5316311731763724 21.755304591368862 -6.725860817750949 1.738050329333657 1.5776727689242553 0.5330536292089129 0.5401036565792678 0.40184037330039135 0.3440480528083977 2.0340561125666086 0.18335517753439678 0.4571783339487017 1.8799191948441367e-07 6.725860817750949 -1.0446191397153424 SPPESENK(ub)EQLEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPPESENKEQLEAR 14 1 Q14534 Q14534 SQLE Squalene monooxygenase 1 10646700.0 5340200.0 2074000.0 3232500.0 True False 6912994.171079378 1958580.076807476 2644218.1682509 1.0 0.283318635650125 0.38249969590789323 22.720879278513543 -10.800519880664469 7.268612139980619 1.0236723490745419 0.3329091657790102 0.9836917320063572 0.040490498296627264 0.013901245506303232 0.00038150590892165525 0.035086869833801916 0.0130682521318731 1.5829971003135827e-11 10.800519880664469 -0.6907631832955317 SPPIPLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPPIPLAK 8 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 13128000.0 1155200.0 6195200.0 5777600.0 False True 1514478.3869727114 5270900.308700463 5179789.374652599 1.0 3.480340395769171 3.4201804523645083 20.530389558992766 -10.148683507353624 4.568085378022658 0.9996838888627764 3.450260424112449 0.9995480864824899 0.024560194203252735 8657111.467377486 5154855.964100389 31025.012385928752 0.008988110786232581 7.100950621149576e-11 10.148683507353624 2.4505765352496724 SPPIPLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPPIPLAK 8 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 8204350.0 2475900.0 907850.0 4820600.0 False True 2397303.909739143 1270359.239375208 3557940.245099883 1.0 0.5299116370745998 1.484142344508599 21.192981382475153 -6.772747867861154 1.5639211958196955 0.7313193682298279 1.4900788836620973 0.7409746493928949 0.1982734659043678 0.26200384939990234 1.2650452756446788 0.09990833195633356 0.23723027407779168 1.6875324476454341e-07 6.772747867861154 0.7587595154322694 SPPIPLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPPIPLAK 8 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 10490700.0 1155200.0 5403600.0 3931900.0 False True 1582308.6581061722 5164851.084684359 3003266.2000223855 1.0 3.2641236324056058 1.8980280393693376 20.593599620515658 -10.268136678006904 6.004100570593197 0.9999362072080652 2.581075835887476 0.6410627220961151 0.5577061904672892 0.0004762593572264553 5.805455290977399e-05 0.5400180617303968 0.17999889897971375 5.3934085836306115e-11 10.268136678006904 1.5811396286794106 SPPIPLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPPIPLAK 8 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 3667360.0 2475900.0 685410.0 506050.0 False True 2058820.5509674973 681717.5602867668 611862.7152891651 1.0 0.331120436876545 0.29719089164989815 20.97338665790943 -13.58232594180555 0.428665882211982 9.999999983918464 0.2964195609991647 0.9998685925749581 0.003709598824960211 21.6181551064974 0.21914841997158785 180.44532910781567 0.008058663174604817 2.6162187761603426e-14 13.58232594180555 -9.703580422919298 SPPPGMGLNQNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPPPGMGLNQNR 12 0 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 0 7843300.0 2067200.0 1349700.0 4426400.0 False True 2001577.8675280735 1888642.2485925173 3266993.050846398 1.0 0.9435767047749032 1.6322088207745313 20.932706311410556 -6.887036722679455 1.0397862684033614 0.9603277675483377 1.6881028447296995 0.9789315878812346 0.04531225517911781 0.1215789695965426 0.2361728868352436 0.033327651859559076 0.08224514383474496 1.2970695899112526e-07 6.887036722679455 0.7277750771813618 SPPTVLVICGPGNNGGDGLVCAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPPTVLVICGPGNNGGDGLVCAR 23 0 Q8NCW5-2;Q8NCW5;Q5T3I4;Q5T3I3 Q8NCW5-2 APOA1BP NAD(P)H-hydrate epimerase 0 8174800.0 1617400.0 4356600.0 2200800.0 False True 2120427.062923879 3706612.261893794 1973082.3275642933 1.0 1.7480498748128162 0.9305117643818361 21.015923428222802 -6.666012635775287 1.9515652321189578 1.4791030738643944 0.9338705406162771 0.2615027635244439 0.31804987651907835 0.4703250160115184 3.449486158461009 0.13138424662386666 0.3528537610139379 2.1576816306049598e-07 6.666012635775287 -0.5452325332481174 SPPTVLVICGPGNNGGDGLVCAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPPTVLVICGPGNNGGDGLVCAR 23 0 Q8NCW5-2;Q8NCW5;Q5T3I4;Q5T3I3 Q8NCW5-2 APOA1BP NAD(P)H-hydrate epimerase 0 9470400.0 1617400.0 3329500.0 4523500.0 False True 2215396.48859152 3182391.6808158616 3455142.464406838 1.0 1.4364885460476318 1.5596045593642291 21.079133489745693 -11.919607316597645 0.21259638192002986 1.3511401528926647e-15 1.6384114507563847 0.9993774572487036 0.005990714620651105 5.021420096120895 0.12966803964254095 2.2956653590071077 0.07122537553691387 1.2033519980341025e-12 11.919607316597645 1.6384114507563834 SPQDDASSPHLQVMLQIHLPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPQDDASSPHLQVMLQIHLPGR 22 0 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7 A0A087WUL4 PEG10 Retrotransposon-derived protein PEG10 0 104228000.0 22076000.0 48955000.0 33197000.0 False True 33490905.97178292 40218597.762839146 26635598.399238016 1.0 1.2008811525350944 0.7953083867506988 24.99726606752758 -6.772042416918404 1.5667776556680473 1.1149194377749245 0.7928566282536976 0.7382660761711408 0.08470900015398314 0.26313723597953803 1.2750977491034217 0.04261003903216193 0.10123484304357169 1.6902758367673527e-07 6.772042416918404 -0.3220628095212269 SPQISMSDIDLNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPQISMSDIDLNLK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 13684600.0 1304100.0 6921800.0 5458700.0 False True 1709687.7289223634 5889094.420965074 4893886.087547796 1.0 3.44454389029103 2.8624444129528093 20.705301413104838 -10.383456666541534 5.955276540770072 0.9995413750867436 3.1534941516219215 0.9480484146117814 0.2376411165032425 0.00144729802142283 0.00014983738532350885 0.23013482905401206 0.07669834054926535 4.135645773388088e-11 10.383456666541534 2.153952776535178 SPQISMSDIDLNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPQISMSDIDLNLK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 14247700.0 4634100.0 2358200.0 7255400.0 False True 4486993.032078091 3299841.557850543 5354993.082665579 1.0 0.7354238204203908 1.1934480495917965 22.097317512956398 -6.75008487229188 1.6496231842064542 0.8444423674717709 1.194359373853818 0.6493083991443851 0.11117678403229636 0.2998922358433616 1.6056876341121804 0.05323993899297055 0.1292359673739285 1.7779319225415895e-07 6.75008487229188 0.34991700638204715 SPQISMSDIDLNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPQISMSDIDLNLK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 13630200.0 1304100.0 5309600.0 7016500.0 False True 1786261.0119773722 5075004.315500787 5359347.20935351 1.0 2.84113255648054 3.0003158404161603 20.76851147462773 -10.403276887554494 0.5014960571584094 3.223340867384387e-19 2.9944280399940384 0.9995572088394729 0.019101784696372543 1.7775777184682042 0.2370656772614376 2.3943338037025725 0.032204490728942284 3.951146315875571e-11 10.403276887554494 2.9944280399940384 SPQVPAAQQMLNFPEKNK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPQVPAAQQMLNFPEKNK 18 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 15716700.0 6097200.0 4655000.0 4964500.0 True False 5903647.723438546 6513765.775504311 3664148.5181924184 1.0 1.103345944854312 0.6206583945795221 22.4931752062355 -6.85070474546394 1.2317167387830377 1.055181867397009 0.6011013354866908 0.941325747937256 0.05026623029581464 0.15667806013426994 0.45706607031970337 0.03192847571059502 0.0739169822426626 1.4102472273264684e-07 6.85070474546394 -0.4540805319103183 SPQVPAAQQMLNFPEKNK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPQVPAAQQMLNFPEKNK 18 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 16350900.0 6097200.0 8389100.0 1864600.0 True False 5070091.95175856 8343906.253194022 2254479.239063683 1.0 1.6457110310001264 0.44466239676022395 22.273580481669775 -6.760652637679212 1.6098235794707452 1.3747535119057397 0.4401011342876455 0.6937199798709188 0.2716149910137652 0.28181117981161624 1.4395101218571378 0.13310978920799546 0.31970224146553283 1.7351913031937785e-07 6.760652637679212 -0.9346523776180942 SPSACLVVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPSACLVVGK 10 0 B9ZVN9;O95602 B9ZVN9 POLR1A DNA-directed RNA polymerase;DNA-directed RNA polymerase I subunit RPA1 0 4149300.0 1735300.0 1188700.0 1225300.0 False True 2274995.104669106 1011350.5935163085 1098517.7099075466 1.0 0.44455066801711096 0.4828659664598812 21.117432010249924 -9.943642520100724 5.9125999245667655 1.0000003044965995 0.4637083190708226 0.9961863204462881 0.015642155088578996 6.277829323404632e-08 1.1222036255886762e-08 0.015145460114662722 0.005048483846301907 1.1385640840670249e-10 9.943642520100724 -0.5362919854257768 SPSDEYK(ub)DNLHQVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPSDEYKDNLHQVSK 15 1 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 1 6185040.0 2523840.0 1633000.0 2028200.0 True False 3308778.680901326 1389362.7653841446 1818341.3198681816 1.0 0.41990199386973687 0.5495506031768971 21.657867364557436 -9.926446192787582 6.952771330762859 1.000000017695539 0.48472629852366705 0.9546711364358883 0.052928823110673935 1.4540054197178034e-08 2.1966965365928658e-09 0.05124811413780439 0.0170827042034986 1.1845511186785432e-10 9.926446192787582 -0.5152737191718719 SPSDEYK(ub)DNLHQVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPSDEYKDNLHQVSK 15 1 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 1 11208080.0 1568700.0 2053700.0 7585680.0 True False 1518902.4771629674 2873753.1199040213 5598762.842477977 1.0 1.8919931747505392 3.686058141754726 20.534597812284627 -6.9599344613915965 0.43635612254726414 0.9333595130208905 4.7142183458652305 0.9997677619362277 0.017022384489938584 0.07972453154931207 0.021217848626513304 0.02355108606813522 0.14875627820015663 1.096643676204859e-07 6.9599344613915965 3.78085883284434 SPSDEYK(ub)DNLHQVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPSDEYKDNLHQVSK 15 1 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 1 32849800.0 4716400.0 4974200.0 23159200.0 True False 7155123.61502614 4086515.1463980093 18581773.96896205 1.0 0.5711313132055623 2.5969885313985825 22.770545261118137 -6.851377752611099 1.2283083962949013 0.7708263497447754 2.680203426537872 0.9422984923707239 0.20938690528922413 0.15595080103790993 0.4520653801222577 0.13333615074609154 0.30885348859393186 1.4080635213662888e-07 6.851377752611099 1.9093770767930964 up SPSDEYK(ub)DNLHQVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPSDEYKDNLHQVSK 15 1 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 1 6167240.0 2523840.0 1773800.0 1869600.0 True False 3456971.852211466 1695427.6508278039 1428038.9856206523 1.0 0.4904372159533838 0.41308956123178114 21.721077426080328 -13.999999999999998 0.26542945278015423 4.8382503042255465 0.3862559350502266 0.9995735983991096 0.005376364304526243 14.664132996622227 0.1630586184921491 30.28852347541032 0.032875406285975614 1.0000000000000041e-14 13.999999999999998 -4.45199436917532 SPSDEYK(ub)DNLHQVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPSDEYKDNLHQVSK 15 1 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 1 8039020.0 1568700.0 3399400.0 3070920.0 True False 1304443.5551931462 3381086.75747193 3713035.1736701955 1.0 2.591976282922644 2.8464513921573356 20.315003087718903 -10.31601292476953 0.39632208945077196 3.2410748897306335e-15 2.872356723076671 0.9991525600441715 0.023785773268376005 1.715715027514986 0.1843245954222048 1.892406788683093 0.06541381944922635 4.830444262393812e-11 10.31601292476953 2.872356723076668 SPSDEYK(ub)DNLHQVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPSDEYKDNLHQVSK 15 1 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 1 33986900.0 4716400.0 5191800.0 24078700.0 True False 6105472.774143061 4902871.766041011 19696623.668325763 1.0 0.8030290114149526 3.226060355512813 22.541671583210587 -6.88719790797565 1.0387727593637197 0.8609292017347248 3.4234047675229715 0.9790449812153781 0.15905308525357054 0.12144790930377225 0.23534192280791827 0.11707010375225001 0.28907492177919847 1.2965882811164248e-07 6.88719790797565 2.5624755657882465 up SPSELFAQHIVTIVHHVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPSELFAQHIVTIVHHVK 18 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 21204900.0 6180500.0 6858400.0 8166000.0 False True 8102695.352047139 5835153.453833806 7321060.653803159 1.0 0.720149678632501 0.9035339890883962 22.9499704679629 -10.177917983727493 4.737306040217725 1.0000239920976797 0.8118418343440018 0.5839669992402394 0.07486633124521216 1.8973347291386292e-05 3.2924443752058453e-06 0.07249825137024936 0.024163004508171795 6.638684297499933e-11 10.177917983727493 -0.18818215775367786 SPSELFAQHIVTIVHHVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPSELFAQHIVTIVHHVK 18 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 28290200.0 9978200.0 6213000.0 12099000.0 False True 9661447.502790535 8693883.300366968 8929908.93778027 1.0 0.8998530807993209 0.9242827159388929 23.203807922841968 -10.471796994871664 6.069246584314726 1.000054746097746 0.9120678983691068 0.945278231929533 0.009973356782386218 7.392669272463459e-06 6.433718206172865e-07 0.009662667816712557 0.0032188870603305454 3.374450059395521e-11 10.471796994871664 -0.08798684772863918 SPSELFAQHIVTIVHHVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPSELFAQHIVTIVHHVK 18 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 33895500.0 6180500.0 13480000.0 14235000.0 False True 8465597.871732349 12884409.027601076 10872986.179027604 1.0 1.5219727209845002 1.2843730996642087 23.01318052948579 -10.103712065538001 4.448525583573853 0.999961855869095 1.4031729103091035 0.7933501950094368 0.09699963931064759 67544947.40056634 2.087403292299333 28731.111125432035 0.033205556561333685 7.875677690318992e-11 10.103712065538001 0.4032110544400085 SPSELFAQHIVTIVHHVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPSELFAQHIVTIVHHVK 18 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 22810700.0 9978200.0 5269800.0 7562700.0 False True 8297315.409210329 5241410.541426596 9144025.60402602 1.0 0.6316995658147978 1.102046282810439 22.984213198276244 -6.69788448507211 1.8390609242045879 0.7708197964225372 1.100563595845062 0.4072860386526628 0.1555259042920192 0.39991911468189867 2.628271540237568 0.06751491513372788 0.1740436657258327 2.0050052536615614e-07 6.69788448507211 0.32974379942252474 SPSIDSIQK(ub)DPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPSIDSIQKDPR 12 1 A0A0D9SF60;Q99569-2;Q99569;B4DRK2;E9PHB5;E7EPC8;Q9UQB3-2;Q9UQB3 A0A0D9SF60 PKP4;CTNND2 Plakophilin-4;Catenin delta-2 1 14292200.0 5405400.0 5399400.0 3487400.0 True False 7086531.74596806 4593830.566696358 3126557.3015029575 1.0 0.6482480755568555 0.4411971065086723 22.75664829310506 -9.517365138565582 0.12381330232918719 1.6548930882348678 2.8748179382162844e-10 0.9998891571561692 0.002428486628044446 0.9749259412912579 0.04910263662162818 0.4306161111879788 0.21470740602434865 3.0383294376930596e-10 9.517365138565582 -1.654893087947386 SPSIDSIQK(ub)DPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPSIDSIQKDPR 12 1 A0A0D9SF60;Q99569-2;Q99569;B4DRK2;E9PHB5;E7EPC8;Q9UQB3-2;Q9UQB3 A0A0D9SF60 PKP4;CTNND2 Plakophilin-4;Catenin delta-2 1 60724200.0 20463800.0 27953400.0 12307000.0 True False 31045080.7041752 22964897.36908892 9874516.055650271 1.0 0.7397274172974017 0.3180702330827655 24.887861346314367 -6.963946047589679 0.3757018748767779 1.0304005299023395 0.012587401615238749 0.9998897434401007 0.0029504073363322853 0.07832045889707945 0.016132290401534383 0.005514247248122403 0.035704987601769704 1.0865605986731872e-07 6.963946047589679 -1.0178131282871008 down SPSIDSIQK(ub)DPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPSIDSIQKDPR 12 1 A0A0D9SF60;Q99569-2;Q99569;B4DRK2;E9PHB5;E7EPC8;Q9UQB3-2;Q9UQB3 A0A0D9SF60 PKP4;CTNND2 Plakophilin-4;Catenin delta-2 1 17721000.0 5243700.0 9211300.0 3266000.0 True False 4360368.88529757 9161676.898600109 3948905.4997221883 1.0 2.1011242717311696 0.9056356477171537 22.056018760857878 -6.664587165685423 1.9563512926033215 1.706100642554322 0.9105515443841349 0.2552624599138016 0.46832808139561616 0.4737482207967494 3.4901351135231677 0.19307333101077792 0.5195517645354556 2.1647753514184813e-07 6.664587165685423 -0.795549098170187 SPSIDSIQK(ub)DPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPSIDSIQKDPR 12 1 A0A0D9SF60;Q99569-2;Q99569;B4DRK2;E9PHB5;E7EPC8;Q9UQB3-2;Q9UQB3 A0A0D9SF60 PKP4;CTNND2 Plakophilin-4;Catenin delta-2 1 59555300.0 20463800.0 29351000.0 9740500.0 True False 26490792.50180408 27717591.04839743 7967828.945969964 1.0 1.0463103754449703 0.3007772963163461 24.658987668406816 -6.892105506284263 1.0098220583426023 1.0380597876033384 0.2339401085972548 0.9822128249798355 0.04548623385493652 0.1174523006967364 0.21199134682988494 0.03422210050556891 0.08599090537007405 1.2820190946957176e-07 6.892105506284263 -0.8041196790060836 down SPSKPLPEVTDEYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPSKPLPEVTDEYK 14 1 P05455;E7ERC4;E9PFL9;E9PGX9 P05455 SSB Lupus La protein 0 8809800.0 2109400.0 1168100.0 5532300.0 False True 2042438.2516271847 1634528.421561027 4083224.6645575487 1.0 0.8002829070885344 1.9991912417937214 20.961861031823478 -6.864087407572403 1.164841947862729 0.8902149826273599 2.0619675757816607 0.9584217078392138 0.10694409269914575 0.14265417122334412 0.36550063305695846 0.07147618240349093 0.16769969055153072 1.367453579578146e-07 6.864087407572403 1.171752593154301 SPSLDNPTPFPNLGPSENPLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPSLDNPTPFPNLGPSENPLKR 22 1 M0QYT9;M0R205;M0QZB8;M0QZB7;Q14653;Q14653-4;M0R0R8;M0R0X9;M0QXC8;M0QX56;M0R3C2;Q14653-3;Q14653-2 M0QYT9 IRF3 Interferon regulatory factor 3 1 9944700.0 1813100.0 2669300.0 5462300.0 True False 2376991.658085378 2271050.8448499055 4897113.594081435 1.0 0.9554307172786607 2.0602148843997075 21.180705409558676 -6.897496411754879 0.9769302497303797 0.9508589327004034 2.1704722828165486 0.9852799311610282 0.06195156458361737 0.11327272330776705 0.18798199037160862 0.047774932027191526 0.12281590250258914 1.2662037291464765e-07 6.897496411754879 1.2196133501161452 up SPSLDNPTPFPNLGPSENPLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPSLDNPTPFPNLGPSENPLKR 22 1 M0QYT9;M0R205;M0QZB8;M0QZB7;Q14653;Q14653-4;M0R0R8;M0R0X9;M0QXC8;M0QX56;M0R3C2;Q14653-3;Q14653-2 M0QYT9 IRF3 Interferon regulatory factor 3 1 17831900.0 3026900.0 4425000.0 10380000.0 True False 2930812.7163412888 6191925.576070155 7661166.606674857 1.0 2.1126991641417168 2.6140075631440403 21.482869349757507 -9.620351835752674 0.21865589665645682 5.4673131243957904e-18 3.01383930909592 0.9993245292554283 0.01752987085674052 1.0477298453818122 0.09045560926198577 0.9453512824536443 0.26160907416102164 2.396890335267208e-10 9.620351835752674 3.01383930909592 SPSLDNPTPFPNLGPSENPLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPSLDNPTPFPNLGPSENPLKR 22 1 M0QYT9;M0R205;M0QZB8;M0QZB7;Q14653;Q14653-4;M0R0R8;M0R0X9;M0QXC8;M0QX56;M0R3C2;Q14653-3;Q14653-2 M0QYT9 IRF3 Interferon regulatory factor 3 1 54242300.0 5098300.0 16604000.0 32540000.0 True False 7734493.835655945 13640886.472355872 26108454.737211358 1.0 1.7636430724750871 3.3755867277121125 22.8828754505676 -6.958976005017993 0.4496321043427809 0.9478222911929403 4.255270752966259 0.9997303172833902 0.016261507219052368 0.0800689485178022 0.022498256699432055 0.02153350145578165 0.13334165244917223 1.0990665617187809e-07 6.958976005017993 3.307448461773318 SPSLDNPTPFPNLGPSENPLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPSLDNPTPFPNLGPSENPLKR 22 1 M0QYT9;M0R205;M0QZB8;M0QZB7;Q14653;Q14653-4;M0R0R8;M0R0X9;M0QXC8;M0QX56;M0R3C2;Q14653-3;Q14653-2 M0QYT9 IRF3 Interferon regulatory factor 3 1 10104400.0 1813100.0 2427800.0 5863500.0 True False 2483452.0671851686 2320531.7683390165 4478662.062573124 1.0 0.934397647130427 1.8034018541172796 21.243915471081568 -6.888698132645222 1.0300330048913282 0.9518398357132373 1.87627090997793 0.9800525986273705 0.05580186465694962 0.1202066066279922 0.22805846513723058 0.0413465095881811 0.10260802777362342 1.292117080185713e-07 6.888698132645222 0.9244310742646927 SPSLDNPTPFPNLGPSENPLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPSLDNPTPFPNLGPSENPLKR 22 1 M0QYT9;M0R205;M0QZB8;M0QZB7;Q14653;Q14653-4;M0R0R8;M0R0X9;M0QXC8;M0QX56;M0R3C2;Q14653-3;Q14653-2 M0QYT9 IRF3 Interferon regulatory factor 3 1 20191500.0 3026900.0 3996600.0 13168000.0 True False 2517001.4644062785 3975069.5225370154 15921367.918047065 1.0 1.5792877273810695 6.325529858919914 21.263274625191784 -6.929654258806628 0.7496237367890952 0.9268895392620512 7.291387530021345 0.9964698440581884 0.14174605483062075 0.09281789213253898 0.07856244015585077 0.1288725696604359 0.43027303516978255 1.1758332615495965e-07 6.929654258806628 6.364497990759294 up SPSLDNPTPFPNLGPSENPLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPSLDNPTPFPNLGPSENPLKR 22 1 M0QYT9;M0R205;M0QZB8;M0QZB7;Q14653;Q14653-4;M0R0R8;M0R0X9;M0QXC8;M0QX56;M0R3C2;Q14653-3;Q14653-2 M0QYT9 IRF3 Interferon regulatory factor 3 1 36244300.0 5098300.0 15303000.0 15843000.0 True False 6599849.852517494 14451374.597581886 12959736.562907655 1.0 2.189652025503194 1.963641121011897 22.65400177266005 -10.12063609058541 4.452141195454425 0.9998769130257927 2.076646573301873 0.9680071952957361 0.09226856565479467 24325083.812097486 8.700782402391413 32647.99879820079 0.033766837438289135 7.574673355920089e-11 10.12063609058541 1.0767696602760801 SPSLQSETVHYK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPSLQSETVHYKR 13 1 O60291-4;O60291;O60291-3;O60291-2;B4DR12;K7EIM7;K7EPJ5;K7ERA1;K7EJN3 O60291-4 MGRN1 E3 ubiquitin-protein ligase MGRN1 1 5526700.0 1474500.0 1896300.0 2155900.0 True False 1933083.779078314 1613379.4317195052 1932828.1488530803 1.0 0.8346143344541216 0.9998677604002473 20.882472734054698 -10.8551881966162 8.637497183413075 1.0046451909256529 0.9172410474323073 0.2506001655245583 0.0674644286358024 0.006320642416087031 0.00010596852024811951 0.06841534853933365 0.021774050713988437 1.3957633916612975e-11 10.8551881966162 -0.08740414349334558 SPSLQSETVHYK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPSLQSETVHYKR 13 1 O60291-4;O60291;O60291-3;O60291-2;B4DR12;K7EIM7;K7EPJ5;K7ERA1;K7EJN3 O60291-4 MGRN1 E3 ubiquitin-protein ligase MGRN1 1 12348400.0 2345300.0 2279800.0 7723300.0 True False 2270849.7352523156 3190136.0289999396 5700336.035966468 1.0 1.4048203980548635 2.510221591272793 21.114800813731527 -6.953544658386366 0.518471173932684 0.9809919696152365 2.9832516513727634 0.9994508979721146 0.01495666170808334 0.08209284693873936 0.03030759505388091 0.016985517487842706 0.0912933335728477 1.1128979479169654e-07 6.953544658386366 2.002259681757527 up SPSLQSETVHYK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPSLQSETVHYKR 13 1 O60291-4;O60291;O60291-3;O60291-2;B4DR12;K7EIM7;K7EPJ5;K7ERA1;K7EJN3 O60291-4 MGRN1 E3 ubiquitin-protein ligase MGRN1 1 20203900.0 2637200.0 8127800.0 9438900.0 True False 4000825.205145221 6677330.587208755 7573297.277783163 1.0 1.668988332362394 1.8929338047669766 21.931866168470368 -10.914082985870802 0.215472574915231 7.718331825466694e-11 2.046065652725612 0.9993145764345837 0.009931108437765283 2.888033748962768 0.11653078256511966 1.576563223721762 0.12552519827210465 1.218756694171592e-11 10.914082985870802 2.0460656526484287 SPSLQSETVHYK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPSLQSETVHYKR 13 1 O60291-4;O60291;O60291-3;O60291-2;B4DR12;K7EIM7;K7EPJ5;K7ERA1;K7EJN3 O60291-4 MGRN1 E3 ubiquitin-protein ligase MGRN1 1 6511000.0 1474500.0 2039800.0 2996700.0 True False 2019662.4968642283 1949674.8912834334 2288941.1789738005 1.0 0.9653468806350273 1.133328554908387 20.94568279557759 -6.8529144187811655 1.220901779859933 0.9814508133520714 1.1404326987222748 0.9444471191472342 0.017067930333654918 0.15427799866543782 0.44106393968704105 0.010930278304205569 0.025345665934872853 1.40309016751801e-07 6.8529144187811655 0.1589818853702034 SPSLQSETVHYK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPSLQSETVHYKR 13 1 O60291-4;O60291;O60291-3;O60291-2;B4DR12;K7EIM7;K7EPJ5;K7ERA1;K7EJN3 O60291-4 MGRN1 E3 ubiquitin-protein ligase MGRN1 1 11187700.0 2345300.0 5085700.0 3756700.0 True False 1950220.8644065058 5058302.324667592 4542208.60098173 1.0 2.5937074189835116 2.3290739443319524 20.895206089165804 -10.112833463375932 4.803300181688982 0.9999199356681464 2.4613906816700415 0.9759969399471481 0.10803616366838913 9.263473938207459e-05 1.710965796968129e-05 0.10461121109884043 0.034868521883627455 7.711991400550185e-11 10.112833463375932 1.4614707460018952 SPSLQSETVHYK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPSLQSETVHYKR 13 1 O60291-4;O60291;O60291-3;O60291-2;B4DR12;K7EIM7;K7EPJ5;K7ERA1;K7EJN3 O60291-4 MGRN1 E3 ubiquitin-protein ligase MGRN1 1 22644100.0 2637200.0 6543900.0 13463000.0 True False 3413907.386983731 6179726.21244958 11012872.142045438 1.0 1.8101622311170886 3.225884856758102 21.702992490562817 -6.962596237689346 0.3971534168645871 0.9196899584155448 4.167813605974948 0.9998547011778043 0.011087925486151368 0.07878640891735278 0.017797695798412633 0.018225828618839764 0.11874276332252495 1.0899429392059137e-07 6.962596237689346 3.2481236475594035 SPSMISNDSETLEECMVCSDMK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPSMISNDSETLEECMVCSDMKR 23 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 50769300.0 7615500.0 35039000.0 8114800.0 True False 11553270.267626066 28786016.68904344 6510906.223156815 1.0 2.491590348206951 0.5635552594490337 23.461797942786664 -6.7001555634388605 1.8304902180869143 1.9260782310546447 0.5693049171415128 0.41826598556146366 0.62960024729058 0.39518331744635393 2.5744672012862972 0.2743978898899157 0.7054975009594421 1.9945477438744026e-07 6.7001555634388605 -1.356773313913132 SPTDCAQSSK(ub)SVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPTDCAQSSKSVK 13 1 O00443 O00443 PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1 5404430.0 677410.0 815220.0 3911800.0 True False 1027680.4953046507 669737.6216570676 3138631.0153971524 1.0 0.6516982901952685 3.0540922297710056 19.970960371320775 -6.870088500338869 1.1335535035844924 0.8028845828644868 3.1950698841529364 0.9647752237766238 0.1989407105934812 0.13677390529671055 0.3284076200747165 0.13618986047552845 0.32250260655236884 1.3486880195343154e-07 6.870088500338869 2.3921853012884498 up SPTDCAQSSK(ub)SVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPTDCAQSSKSVK 13 1 O00443 O00443 PIK3C2A Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha 1 4039360.0 677410.0 540350.0 2821600.0 True False 876920.5987474024 510279.0474941751 2308097.752060865 1.0 0.581898803863269 2.632048734352646 19.742086693413224 -6.853580404831898 1.2176311090891736 0.7759986518426443 2.7198721542842415 0.9453628878665272 0.20675470584992137 0.15356148624815555 0.4363165850332232 0.13273382004739231 0.30795229990196826 1.400940192308407e-07 6.853580404831898 1.9438735024415972 up SPTDWALFTYEGNSNDIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPTDWALFTYEGNSNDIR 18 0 Q9UJU6;F8WBG8;F8WC20;F8WBB2;F8WFE1;Q9UJU6-2;Q9UJU6-3;B4DDD6;Q9UJU6-6 Q9UJU6;Q9UJU6-2 DBNL Drebrin-like protein 0 2155660.0 434420.0 937020.0 784220.0 False True 569528.8269292647 797220.2684753533 703076.4371694245 1.0 1.3997891428494238 1.2344878852931993 19.11940934080456 -10.211863718205835 5.3461298656548095 0.9999806014140871 1.317138514071367 0.8307314544978398 0.06748395580904917 1.5604092950219595e-05 2.300323066887715e-06 0.06534505158790217 0.02178035308202571 6.139546341664656e-11 10.211863718205835 0.3171579126572799 SPTQSQPAFLATNEEK(ub)CAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPTQSQPAFLATNEEKCAR 19 1 A0A0A0MR27;J3QT39;Q49A88-2;Q49A88-3;Q49A88-6;Q49A88;Q49A88-4;C9JSI8 A0A0A0MR27 CCDC14 Coiled-coil domain-containing protein 14 1 19896700.0 5379800.0 7707100.0 6809800.0 True False 7052969.898057308 6557230.7220405005 6105187.220214156 1.0 0.9297119960552568 0.8656193502110066 22.74979945165414 -6.972226194276591 0.19791620457871986 1.0391904593842247 0.7543752618520884 0.9999949269889317 0.0001234734428749129 0.07558675562090462 0.006374140694050104 0.0021170080677610187 0.00684052448486601 1.0660407489387874e-07 6.972226194276591 -0.28481519753213635 SPTQSQPAFLATNEEK(ub)CAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPTQSQPAFLATNEEKCAR 19 1 A0A0A0MR27;J3QT39;Q49A88-2;Q49A88-3;Q49A88-6;Q49A88;Q49A88-4;C9JSI8 A0A0A0MR27 CCDC14 Coiled-coil domain-containing protein 14 1 13719400.0 3829600.0 4093800.0 5796000.0 True False 3708031.444217055 5728475.688884974 4277853.723727113 1.0 1.5448832554586205 1.1536724507551674 21.822222047436394 -10.180627159740865 9.260805214380746 0.9999999962943302 1.3492778531068939 0.515226402808806 0.1597111422311769 2.9650891636253894e-08 2.737063817060677e-09 0.1546396531248931 0.051546549505426004 6.597400366557768e-11 10.180627159740865 0.3492778568125636 SPTQSQPAFLATNEEK(ub)CAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPTQSQPAFLATNEEKCAR 19 1 A0A0A0MR27;J3QT39;Q49A88-2;Q49A88-3;Q49A88-6;Q49A88;Q49A88-4;C9JSI8 A0A0A0MR27 CCDC14 Coiled-coil domain-containing protein 14 1 57720200.0 9122200.0 31022000.0 17576000.0 True False 13839044.322150655 25485881.7240077 14102095.89616555 1.0 1.8415926078952733 1.0190079291525829 23.72224098295938 -10.337909904387773 4.5513623951671445 0.9995827852501482 1.4303002685251087 0.26732163371945117 0.33581878886249134 0.001423050014209594 0.00020701263734485874 0.3254640791035089 0.10838504805009833 4.592932846385174e-11 10.337909904387773 0.4307174832749605 SPTQSQPAFLATNEEK(ub)CAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPTQSQPAFLATNEEKCAR 19 1 A0A0A0MR27;J3QT39;Q49A88-2;Q49A88-3;Q49A88-6;Q49A88;Q49A88-4;C9JSI8 A0A0A0MR27 CCDC14 Coiled-coil domain-containing protein 14 1 20803400.0 5379800.0 6267700.0 9155900.0 True False 7368857.443628458 5990772.289487785 6993464.9916795865 1.0 0.8129852335069603 0.9490568986005479 22.813009513177033 -10.27775725016131 5.3630550963405526 1.0000159236193555 0.8810210660790314 0.5048027455017378 0.055551024655057984 1.0578093640960276e-05 1.4245309959470105e-06 0.05379424489905872 0.01792901611281215 5.275246400685318e-11 10.27775725016131 -0.11899485754032413 SPTQSQPAFLATNEEK(ub)CAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPTQSQPAFLATNEEKCAR 19 1 A0A0A0MR27;J3QT39;Q49A88-2;Q49A88-3;Q49A88-6;Q49A88;Q49A88-4;C9JSI8 A0A0A0MR27 CCDC14 Coiled-coil domain-containing protein 14 1 13811200.0 3829600.0 4606000.0 5375600.0 True False 3184482.080045686 4581186.563780581 6499613.106033858 1.0 1.4385970618226425 2.0410267486701046 21.60262732287067 -6.966679484726171 0.32795092012577876 0.9248290291975009 2.5744559710653014 0.999943697115882 0.0032021098692831635 0.07739556535287047 0.012874755072086618 0.00885572788532563 0.052632953928698975 1.0797432935874647e-07 6.966679484726171 1.6496269418678007 SPTQSQPAFLATNEEK(ub)CAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPTQSQPAFLATNEEKCAR 19 1 A0A0A0MR27;J3QT39;Q49A88-2;Q49A88-3;Q49A88-6;Q49A88;Q49A88-4;C9JSI8 A0A0A0MR27 CCDC14 Coiled-coil domain-containing protein 14 1 52812200.0 9122200.0 33339000.0 10351000.0 True False 11808867.725444777 31483655.342663683 8467224.21022895 1.0 2.666102802966053 0.7170225297709509 23.49336730505183 -6.680343680147547 1.9005144322250598 2.0538248701080084 0.724392518243179 0.3257701914221689 0.7060787130339743 0.4377567060194402 3.0572695911236423 0.2980684768432222 0.7858333864747262 2.0876434145703105e-07 6.680343680147547 -1.3294323518648294 SPTTTQSPK(ub)SSFLASLNPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPTTTQSPKSSFLASLNPK 19 1 Q14669-4;Q14669;Q14669-2;Q14669-3 Q14669-4 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 6306800.0 0.0 5197400.0 1109400.0 True False 0.0 4421968.17930652 994609.9301162418 0.0 SPVAK(ub)DVDLEFLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPVAKDVDLEFLAK 14 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 464195500.0 124938000.0 271713000.0 67544500.0 True False 163794927.901313 231174479.52897832 60555643.07259462 1.0 1.4113653120459366 0.36970401860721597 27.287315442055117 -6.799582272546885 1.4576960986720064 1.2270955545830662 0.35548908990274064 0.8308913550064986 0.1761602294723696 0.22137163581952357 0.9287168345561118 0.09507369428715129 0.2211551211866674 1.5864183601191917e-07 6.799582272546885 -0.8716064646803255 down SPVAK(ub)DVDLEFLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPVAKDVDLEFLAK 14 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 805006000.0 345885000.0 320823000.0 138298000.0 True False 334905070.00287634 448929296.9698435 102073604.9489325 1.0 1.340467306051795 0.3047836957142985 28.31917697573069 -6.818123020616824 1.3798818313861996 1.1838636008303751 0.2830524259480885 0.8800432720301942 0.14927743088535592 0.19592354449273952 0.7335163197808858 0.08502120771500649 0.19607402388815526 1.520116872167915e-07 6.818123020616824 -0.9008111748822867 down SPVAK(ub)DVDLEFLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPVAKDVDLEFLAK 14 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 674913000.0 374754000.0 218272000.0 81887000.0 True False 568529216.1872407 179319656.23308027 65701998.55765285 1.0 0.3154097469883108 0.1155648587389648 29.08265924887676 -11.549730578343544 0.22176106663954806 2.323492786341019 3.336576827472503e-15 0.9993167621545513 0.009899168160162232 4.188962080099922 0.13067293490448936 2.7536805537011815 0.10761746301273518 2.8201319034726067e-12 11.549730578343544 -2.3234927863410153 SPVAK(ub)DVDLEFLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPVAKDVDLEFLAK 14 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 411327200.0 124938000.0 218458000.0 67931200.0 True False 171130954.92249748 208805803.21599966 51887249.646979995 1.0 1.2201521537150573 0.303202010825446 27.35052550357801 -6.843312982074699 1.2668458881193936 1.1171171785407261 0.2709961799657859 0.930010441095501 0.10339841149655452 0.16496669606032596 0.5128390694474989 0.0639604625561619 0.14751622972079367 1.4344552949361945e-07 6.843312982074699 -0.8461209985749403 down SPVAK(ub)DVDLEFLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPVAKDVDLEFLAK 14 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 781083000.0 345885000.0 337405000.0 97793000.0 True False 287618702.803583 335587332.29535145 118241064.15625599 1.0 1.1667785475151335 0.4111035304856503 28.099582251164968 -6.8488307020376284 1.2406830990348523 1.0889205642743303 0.3815636265017396 0.9385885389391543 0.0803286944794564 0.15875121068995668 0.4708238406974421 0.050677447405963916 0.11718906320091611 1.4163457964727742e-07 6.8488307020376284 -0.7073569377725907 down SPVAK(ub)DVDLEFLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPVAKDVDLEFLAK 14 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 708904500.0 374754000.0 288081000.0 46069500.0 True False 485126440.50572586 272049039.1064489 37685323.71298834 1.0 0.5607796574081761 0.07768144666306545 28.853785570969208 -7.758288181673522 0.5015420354704789 1.0200173105437558 4.1143390063464545e-23 0.9951482658433701 0.02623720471990291 0.11391655513468471 0.09980582744573023 0.03223646058783002 0.07676998661167928 1.744664074511231e-08 7.758288181673522 -1.0200173105437558 down SPVLHFYVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPVLHFYVR 9 0 O15067;J3QSG0;J3QSH6;J3QL39;J3KTL4 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 4840100.0 1501800.0 1649800.0 1688500.0 False True 1968874.3434518862 1403656.2708700325 1513790.2172356895 1.0 0.7129232373504866 0.7688607565385152 20.908939608515084 -10.690441415827028 6.732492074176288 1.0021349126607642 0.7408919969445018 0.966225830136882 0.022836396581302203 0.0007370115141474004 3.388755897367882e-05 0.022269070192548233 0.0073704153038976145 2.0396637815861815e-11 10.690441415827028 -0.26124291571626235 SPVLHFYVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPVLHFYVR 9 0 O15067;J3QSG0;J3QSH6;J3QL39;J3KTL4 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 4801600.0 1501800.0 1811200.0 1488600.0 False True 2057056.044618984 1731175.1951625433 1137023.3386793456 1.0 0.8415790127308848 0.5527430045737765 20.972149670037975 -6.961813938186375 0.4090730679579594 1.0143729074148544 0.3692463869432648 0.9998316576899579 0.002402401233202237 0.0790594796886845 0.018783682526915545 0.00371840297597753 0.024122909460621712 1.0919080349442135e-07 6.961813938186375 -0.6451265204715897 SPVLHFYVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPVLHFYVR 9 0 O15067;J3QSG0;J3QSH6;J3QL39;J3KTL4 O15067 PFAS Phosphoribosylformylglycinamidine synthase 0 8115500.0 2710300.0 3332400.0 2072800.0 False True 3508536.7780001555 3146949.0105849747 1695571.6687240421 1.0 0.8969405794226037 0.48327031352668554 21.742438054768403 -6.944794987326254 0.6133346624333177 1.0045557607646138 0.3539888540341871 0.9987268831571788 0.007967404786044421 0.0856456269227601 0.04514862404445023 0.00807331994492226 0.034923150651548815 1.1355467343691667e-07 6.944794987326254 -0.6505669067304267 down SPVPVSGQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPVPVSGQKR 10 1 A0A0A0MRB5;Q8WXG6-6;Q8WXG6-8;Q8WXG6-5;Q8WXG6-4;Q8WXG6-7;Q8WXG6-3;Q8WXG6-2;Q8WXG6;C9J6B0 A0A0A0MRB5 MADD MAP kinase-activating death domain protein 1 5470770.0 781370.0 1262600.0 3426800.0 True False 1185395.4157986953 1037279.1652611735 2749491.477980205 1.0 0.8750490776634866 2.319472001777275 20.176936952713994 -6.88584179893876 1.0466407682511754 0.914478332612453 2.434050036779654 0.9781016266372307 0.09669823500250578 0.12258296179254698 0.24206157024156905 0.07075034454065401 0.173942014956466 1.300643278905222e-07 6.88584179893876 1.519571704167201 up SPVPVSGQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPVPVSGQKR 10 1 A0A0A0MRB5;Q8WXG6-6;Q8WXG6-8;Q8WXG6-5;Q8WXG6-4;Q8WXG6-7;Q8WXG6-3;Q8WXG6-2;Q8WXG6;C9J6B0 A0A0A0MRB5 MADD MAP kinase-activating death domain protein 1 3604630.0 781370.0 816660.0 2006600.0 True False 1011498.8681053678 771212.1530981639 1641419.3894546826 1.0 0.7624448997582336 1.6227594920884243 19.948063274806444 -6.8330766166427575 1.3142060355264074 0.8733150348211416 1.6473824973051667 0.9118714344479342 0.10769284402795257 0.17704535449409584 0.5969481931693894 0.06432032520391173 0.1480135522978498 1.4686671579041362e-07 6.8330766166427575 0.7740674624840251 SPVYLTVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPVYLTVLK 9 0 E9PLK3;P55786;P55786-2 E9PLK3 NPEPPS Puromycin-sensitive aminopeptidase 0 8590200.0 2073900.0 2402000.0 4114300.0 False True 2718902.983676169 2043630.9629226676 3688591.7031523813 1.0 0.751638059611645 1.3566470467310008 21.374593243133933 -6.795218179898263 1.4752258045098567 0.8621286474118092 1.3640587234960149 0.8178645771374281 0.10597168245416215 0.22764612598033818 0.9784877451516509 0.05652431729975121 0.13186354646663473 1.6024401581101522e-07 6.795218179898263 0.5019300760842057 SPVYLTVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPVYLTVLK 9 0 E9PLK3;P55786;P55786-2 E9PLK3 NPEPPS Puromycin-sensitive aminopeptidase 0 8572000.0 2073900.0 2487100.0 4011000.0 False True 2840676.875040162 2377211.698260135 3063684.409138017 1.0 0.8368469216431121 1.0785050690056757 21.437803304656825 -6.724837505048425 1.741909061834923 0.901256535571178 1.0782351800858692 0.5352562665685261 0.06861780433634307 0.34599433021198206 2.054177139739582 0.031247530968986012 0.07800021057730201 1.8843540045862107e-07 6.724837505048425 0.17697864451469114 SPVYLTVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPVYLTVLK 9 0 E9PLK3;P55786;P55786-2 E9PLK3 NPEPPS Puromycin-sensitive aminopeptidase 0 2958200.0 1199100.0 724900.0 1034200.0 False True 997104.77913693 720994.8198186164 1250446.4383994746 1.0 0.723088320209128 1.254077269072796 19.92738559029251 -6.7650068650343 1.5937239349589298 0.8401563622041469 1.256504606446641 0.7110142007442555 0.11656869214928957 0.2745952184849615 1.3756547325584836 0.05768196706215898 0.13793680284303678 1.717881231834917e-07 6.7650068650343 0.41634824424249406 SPWSNK(ub)YDPPLEDGAMPSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPWSNKYDPPLEDGAMPSAR 20 1 P47756-2;B1AK88;B1AK87;P47756;B1AK85;A0A6I8PRV6 P47756-2 CAPZB F-actin-capping protein subunit beta 1 8023200.0 2732300.0 2376200.0 2914700.0 True False 2645564.6320854058 3325029.0517193 2151252.630874297 1.0 1.2568315328203856 0.813154441507082 21.335144233053207 -6.7497542173378555 1.6506772498202242 1.1510655648344388 0.8122859788883585 0.6479169492836299 0.10792139277023624 0.3004882735672731 1.6108046347660225 0.05164820578812929 0.12542404271905713 1.779286086305307e-07 6.7497542173378555 -0.33877958594608026 SPWSNK(ub)YDPPLEDGAMPSAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPWSNKYDPPLEDGAMPSAR 20 1 P47756-2;B1AK88;B1AK87;P47756;B1AK85;A0A6I8PRV6 P47756-2 CAPZB F-actin-capping protein subunit beta 1 28408200.0 2151200.0 10907000.0 15350000.0 True False 3263527.6737859817 8960560.633220047 12316065.771855993 1.0 2.7456671212550194 3.7738505699779354 21.638000842321393 -8.608194405406216 0.2336514031643318 2.1279139919425333e-19 4.664015698028834 0.9994277270437054 0.027390412040784413 0.21679858298603183 0.0657772151444283 0.5916966790325886 0.43597280646997144 2.464935698771436e-09 8.608194405406216 4.664015698028834 SPWSNK(ub)YDPPLEDGAMPSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPWSNKYDPPLEDGAMPSAR 20 1 P47756-2;B1AK88;B1AK87;P47756;B1AK85;A0A6I8PRV6 P47756-2 CAPZB F-actin-capping protein subunit beta 1 7100200.0 2732300.0 2914100.0 1453800.0 True False 2272028.511413421 2898401.1648964416 1757782.858388278 1.0 1.2756887294047892 0.7736623240237277 21.115549508487483 -6.757638491493968 1.6216750239333648 1.1606068866355888 0.7720590530780346 0.681135879623358 0.11591832945416285 0.28690007695646114 1.4865403564340027 0.05641748266558045 0.13588108696918424 1.7472759874381502e-07 6.757638491493968 -0.3885478335575542 SPWVCLTCSSVHCGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPWVCLTCSSVHCGR 15 0 Q6JHV3;H0YMI4;Q9Y6I4;H0YL81;H0YNX9;H0YLJ0;H0YMP6 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 0 14521700.0 3450500.0 5094500.0 5976700.0 False True 4523638.914689537 4334420.458205466 5358288.416554658 1.0 0.9581711847358937 1.1845084273094337 22.10905234463395 -6.858977081956609 1.1907978609537324 0.9773619904112498 1.1952613843162874 0.9523900064581503 0.021455627277369195 0.14786607767590873 0.3989886307480896 0.014058077768311143 0.03278096071516632 1.3836393927269352e-07 6.858977081956609 0.21789939390503754 SPWVCLTCSSVHCGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPWVCLTCSSVHCGR 15 0 Q6JHV3;H0YMI4;Q9Y6I4;H0YL81;H0YNX9;H0YLJ0;H0YMP6 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 0 14769100.0 3450500.0 5217400.0 6101200.0 False True 4726243.096256372 4986878.016365426 4660222.218158289 1.0 1.0551463212536616 0.9860310024784004 22.172262406156843 -6.694191140003229 1.8516823261013948 1.0344365876478814 0.9862580239115125 0.39006792446152483 0.02330353697266498 0.40770561017741275 2.713479567019664 0.010056272634659127 0.026048212388131948 2.0221290112252924e-07 6.694191140003229 -0.04817856373636886 SPYLYPLYGLGELPQGFAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPYLYPLYGLGELPQGFAR 19 0 P31150;P50395;P50395-2;Q5SX91;Q5SX87 P31150;P50395 GDI1;GDI2 Rab GDP dissociation inhibitor alpha;Rab GDP dissociation inhibitor beta 0 79737000.0 14579000.0 45893000.0 19265000.0 False True 22117408.867667284 37703035.58635439 15457264.305850556 1.0 1.7046768819954865 0.6988731997646896 24.398679042879518 -6.718350317796726 1.7650393621489924 1.4294593733024135 0.700559929094756 0.5048450421926562 0.2965912400372106 0.3585180805199283 2.1818692967045417 0.13346424878495772 0.3357238597897135 1.9127124388515134e-07 6.718350317796726 -0.7288994442076575 SPYLYPLYGLGELPQGFAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SPYLYPLYGLGELPQGFAR 19 0 P31150;P50395;P50395-2;Q5SX91;Q5SX87 P31150;P50395 GDI1;GDI2 Rab GDP dissociation inhibitor alpha;Rab GDP dissociation inhibitor beta 0 41582000.0 14579000.0 14437000.0 12566000.0 False True 18872802.895053767 13633568.258857042 10279116.938048193 1.0 0.7223923406962599 0.5446523759723136 24.169805364971968 -8.866453878629011 0.10094059646540221 1.6088323671341715 5.134140733348344e-13 0.9999680678001028 0.001058838051192598 0.3714052617221542 0.0301933025504132 0.26173757056348224 0.19969475714702356 1.3600225878129251e-09 8.866453878629011 -1.6088323671336582 SPYNYLQVAYFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPYNYLQVAYFK 12 0 Q32P28-4;Q32P28;Q32P28-3;E2QRI1;Q32P28-2 Q32P28-4 LEPRE1;P3H1 Prolyl 3-hydroxylase 1 0 3221500.0 1671800.0 0.0 1549700.0 False True 2191745.9897342287 0.0 1389351.9097720745 1.0 0.0 0.633901882918717 21.063649177574636 -10.231093803536648 7.219343608526723 1.0000019206749051 0.3169509414593586 0.6075504146083037 0.2587893600233901 8.000418803117467e-06 8.523424297647114e-07 0.25057242581898015 0.08352390679552212 5.873624740400264e-11 10.231093803536648 -0.6830509792155466 SPYNYLQVAYFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPYNYLQVAYFK 12 0 Q32P28-4;Q32P28;Q32P28-3;E2QRI1;Q32P28-2 Q32P28-4 LEPRE1;P3H1 Prolyl 3-hydroxylase 1 0 6801000.0 1671800.0 2340100.0 2789100.0 False True 2289909.6386962435 2236706.644324133 2130372.023317588 1.0 0.9767663345867214 0.930330169940903 21.126859239097527 -6.960058505319711 0.43461645320418263 1.0017566998800005 0.9035454378808252 0.9997723028255189 0.00043701195762069895 0.0796803303693786 0.021054868090693152 0.0006083925094410367 0.0038516822713807 1.0963304957017423e-07 6.960058505319711 -0.09821126199917529 SPYQEFTDHLVK(ub)THTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPYQEFTDHLVKTHTR 16 1 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 184173000.0 11360000.0 110370000.0 62443000.0 True False 14893070.010396494 93903226.21889037 55981997.355551176 1.0 6.3051624784774924 3.7589293084952593 23.828137841385004 -9.575410020189128 9.089099551642278 1.0001610386288027 5.032045893486352 0.7697676554527075 1.039495342925655 0.0 0.0 1.0064870210286012 0.3354956786746705 2.658214237734955e-10 9.575410020189128 4.031884854857549 SPYQEFTDHLVK(ub)THTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SPYQEFTDHLVKTHTR 16 1 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 242058700.0 67359000.0 106899700.0 67800000.0 True False 65220725.415452465 149585307.6845711 50041146.043598734 1.0 2.2935241325778093 0.7672583480916436 25.958827151717045 -6.6820812826156395 1.8941779313629958 1.816867741223966 0.7729213587741288 0.3338497275193 0.5479739243589468 0.43389544505296856 3.0115577376937677 0.23196392014962755 0.6102333077115628 2.07930748720496e-07 6.6820812826156395 -1.0439463824498372 SPYQEFTDHLVK(ub)THTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPYQEFTDHLVKTHTR 16 1 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 977490000.0 718780000.0 123700000.0 135010000.0 True False 1090441809.856774 101624768.52748875 108325214.32301475 1.0 0.0931959574631835 0.09934066480561939 30.022265638296897 -10.296422691943691 4.255812255694681 1.000915470047391 0.09626831111581595 0.9999653285572817 0.0025085663333099797 28707371.6640719 50144424.84683783 331883.003934702 0.0009180382399638587 5.053325903691732e-11 10.296422691943691 -0.9046471589315751 SPYQEFTDHLVK(ub)THTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPYQEFTDHLVKTHTR 16 1 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 235407000.0 11360000.0 90250000.0 133797000.0 True False 15560098.992456842 86262456.58316001 102196904.23571168 1.0 5.5438244078638546 6.567882651984043 23.891347902907896 -9.415334636610645 0.46479091015691476 2.8929090960393606e-20 6.607539488583091 0.9981286360586156 0.104676249085735 0.7593947489812555 0.1936587149853588 1.595452436521562 0.22133483549800817 3.842955569595149e-10 9.415334636610645 6.607539488583091 SPYQEFTDHLVK(ub)THTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SPYQEFTDHLVKTHTR 16 1 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 251693500.0 67359000.0 121921300.0 62413200.0 True False 56011993.00966093 121264485.75741686 75463511.55396847 1.0 2.164973593003577 1.347274172889234 25.73923242715132 -10.17924399682136 4.844657138986079 0.999920143269419 1.7561238829488843 0.5327288614175084 0.3338243903835209 0.0002879644327217274 4.8786246803371675e-05 0.3232579547867439 0.10774135870821823 6.618445594385306e-11 10.17924399682136 0.7562037396794653 SPYTLDSLYWSVK(ub)PASSSFGSEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SPYTLDSLYWSVKPASSSFGSEAK 24 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 96653000.0 13026000.0 32500000.0 51127000.0 True False 19761394.32815928 26700121.07634103 41021726.04023981 1.0 1.3511253625607942 2.0758518027134008 24.236181408672184 -6.959424541001042 0.4434775345344852 0.9750066212188706 2.4803899483640075 0.9997482348756128 0.007107750882290179 0.07990744588251468 0.02189648071643778 0.009597945289274617 0.060010013027675224 1.0979320402349116e-07 6.959424541001042 1.505383327145137 up SPYTVTVGQACNPSACR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SPYTVTVGQACNPSACR 17 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98 P21333-2 FLNA Filamin-A 0 2833200.0 0.0 1502100.0 1331100.0 False True 0.0 1277992.535139941 1193370.5408128083 0.0 SPYTVTVGQACNPSACR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SPYTVTVGQACNPSACR 17 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98 P21333-2 FLNA Filamin-A 0 3083400.0 0.0 1457400.0 1626000.0 False True 0.0 1393007.2490226862 1241972.2885211727 0.0 SQAFIEMETR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQAFIEMETR 10 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4 P43243 MATR3 Matrin-3 0 37043000.0 0.0 18541000.0 18502000.0 False True 0.0 15774755.07225195 16587590.523716139 0.0 SQAFIEMETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQAFIEMETR 10 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4 P43243 MATR3 Matrin-3 0 38387200.0 14034000.0 5075200.0 19278000.0 False True 13588498.351823218 7101753.826818361 14228513.472396703 1.0 0.5226297743094985 1.047099768054033 23.695882698677575 -6.667077939490286 1.9471874959399003 0.6945528699327437 1.04498311124345 0.2664767337743814 0.2029103736987044 0.4678120436458884 3.4165454602900294 0.08396635966698139 0.2252399318370142 2.152395426209532e-07 6.667077939490286 0.3504302413107063 SQAFIEMETR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQAFIEMETR 10 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4 P43243 MATR3 Matrin-3 0 35016000.0 0.0 18416000.0 16600000.0 False True 0.0 17602320.226431858 12679421.887731517 0.0 SQAFNK(ub)LPQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQAFNKLPQR 10 1 Q9Y5Z9 Q9Y5Z9 UBIAD1 UbiA prenyltransferase domain-containing protein 1 1 19483720.0 835520.0 1589200.0 17059000.0 True False 808996.8749405254 2223775.8475685203 12590736.140969774 1.0 2.748806474353816 15.563392802840431 19.62577460414211 -6.9317677923780945 0.7321374061699862 0.81733779690866 18.316630599030848 0.9968743421600125 0.3629758448800035 0.0917305468452942 0.07325974855923863 0.3342341695588914 1.148438480438748 1.1701248635897638e-07 6.9317677923780945 17.499292802122188 SQAFNK(ub)LPQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQAFNKLPQR 10 1 Q9Y5Z9 Q9Y5Z9 UBIAD1 UbiA prenyltransferase domain-containing protein 1 1 13100020.0 835520.0 1998500.0 10266000.0 True False 694771.8998119317 1987733.6838288072 12412573.135379065 1.0 2.8609874469115235 17.86568100802441 19.406179879576385 -6.929950277262648 0.747197245788096 0.7714042440472538 20.94219977311027 0.9965285148306111 0.44485501524191173 0.09266363281625982 0.07780591396332082 0.4051647112362436 1.358037166951418 1.175032077640896e-07 6.929950277262648 20.170795529063017 SQAPGQPGASQWGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQAPGQPGASQWGSR 15 0 K7EQ02;K7EQ55;K7EK33;Q96EP5-2;Q96EP5 K7EQ02 DAZAP1 DAZ-associated protein 1 0 7697800.0 1000900.0 3266300.0 3430600.0 False True 1312189.5927293883 2778980.771937683 3075634.4206388863 1.0 2.117819549351349 2.3438948439161806 20.323544753250694 -10.562876911325882 0.32917215725412785 3.352343302827212e-24 2.396502983177916 0.9991330976921461 0.01729865496853252 2.124061571658473 0.15903781955610372 1.8227881836632618 0.07223722760056973 2.736044071909263e-11 10.562876911325882 2.396502983177916 SQAPGQPGASQWGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQAPGQPGASQWGSR 15 0 K7EQ02;K7EQ55;K7EK33;Q96EP5-2;Q96EP5 K7EQ02 DAZAP1 DAZ-associated protein 1 0 8764800.0 2555500.0 1351000.0 4858300.0 False True 2474377.0513099786 1890461.3453719264 3585765.484124131 1.0 0.7640150656792921 1.4491588831321256 21.2386339276042 -6.813719874104936 1.3989192320739121 0.8719454553862999 1.462183583240497 0.8693029189087778 0.10273903285156002 0.20176963365877887 0.7775053020901216 0.05773711217671858 0.1333420976934255 1.5356071510947414e-07 6.813719874104936 0.5902381278541972 SQAPGQPGASQWGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQAPGQPGASQWGSR 15 0 K7EQ02;K7EQ55;K7EK33;Q96EP5-2;Q96EP5 K7EQ02 DAZAP1 DAZ-associated protein 1 0 8447100.0 1000900.0 4575400.0 2870800.0 False True 1370959.7783054626 4373243.69917552 2192776.165981909 1.0 3.1899139335662703 1.5994460236406278 20.386754814773585 -6.563707533455129 2.331992458694301 2.5055710297074403 1.6022793639032116 0.0 0.9552679169402839 0.7495047760334153 7.64350736959378 0.3476476955210343 1.0729131657323123 2.730816174821625e-07 6.563707533455129 -0.9032916658042287 SQAPGQPGASQWGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQAPGQPGASQWGSR 15 0 K7EQ02;K7EQ55;K7EK33;Q96EP5-2;Q96EP5 K7EQ02 DAZAP1 DAZ-associated protein 1 0 4933130.0 2555500.0 1806800.0 570830.0 False True 2125011.477845404 1797066.4097782802 690187.9137802868 1.0 0.8456737427133173 0.32479255805247864 21.019039203038478 -6.9487764529330365 0.5721246635777267 1.006427874870873 0.13862125529158717 0.9991016878986169 0.008658117741669427 0.0839809379336013 0.03802555612190698 0.009150672339026474 0.043422472125044353 1.1251839978041829e-07 6.9487764529330365 -0.8678066195792858 down SQASTTVDINTQVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQASTTVDINTQVEK 15 0 Q14676-3;Q14676;Q14676-2;Q14676-4 Q14676-3 MDC1 Mediator of DNA damage checkpoint protein 1 0 2243310.0 0.0 1527200.0 716110.0 False True 0.0 1299347.712978975 642013.8066121698 0.0 SQCEELK(ub)TEVEQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQCEELKTEVEQLK 14 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 20217700.0 5991700.0 8371700.0 5854300.0 True False 7855176.723705331 7122674.992631003 5248553.194410956 1.0 0.9067491723179459 0.6681648776369202 22.905212302583337 -6.95496387041901 0.5013979193136665 1.0047207488350787 0.5598784750741425 0.9995354416356123 0.0030117881400720395 0.08155163677164368 0.028171383386963757 0.0035228340650382954 0.01968203518815432 1.1092670929448122e-07 6.95496387041901 -0.4448422737609362 SQCEELK(ub)TEVEQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQCEELKTEVEQLK 14 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 16337300.0 7789400.0 5049600.0 3498300.0 True False 7542129.760701993 7065931.613316127 2581990.283249579 1.0 0.9368615812118376 0.3423423310353198 22.846540541271644 -6.927197076820037 0.7694558428623934 1.0100427153163134 0.22857012108533378 0.9959580063581657 0.01883550296213801 0.0941196987551121 0.0850046121865417 0.016882111847836976 0.054646330771091704 1.1825048296433187e-07 6.927197076820037 -0.7814725942309796 down SQCEELK(ub)TEVEQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQCEELKTEVEQLK 14 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 11925600.0 7789400.0 0.0 4136200.0 True False 6477231.228929362 0.0 5001060.296371986 1.0 0.0 0.7720984660908305 22.62694581670592 -10.850850535922357 9.968005267219073 1.020017549098473 0.3860492335462518 0.45742518969674173 0.31520787885135243 0.11955903100147058 0.0017889371123081743 0.26022365979283085 0.10173290544872117 1.4097738939256506e-11 10.850850535922357 -0.6339683155522213 SQCEELK(ub)TEVEQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQCEELKTEVEQLK 14 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 46716000.0 19211000.0 27505000.0 0.0 True False 24869018.2054241 25974322.5711618 0.0 1.0 1.044445034243315 0.0 24.567846217278024 -6.992418696018229 1.1335264424405032 1.0370453969203726 2.9029107601633056e-19 0.9820033010264388 0.06469091075934028 0.09374612186927984 0.23634793336651502 0.04799973666212093 0.0884460256922646 1.017609854415048e-07 6.992418696018229 -1.0370453969203726 down SQDFGNLFSFPSYSQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQDFGNLFSFPSYSQK 16 0 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 0 2387240.0 478080.0 992740.0 916420.0 False True 626767.5097333065 844627.0616702123 821597.6493213692 1.0 1.3475922866991086 1.3108491371401243 19.257570870007473 -10.029583662034877 4.446292734330091 0.9999846949679648 1.3292207119379393 0.990744466597183 0.015000328125467541 2281783.6417698218 2573530.5894801226 280.87009854275306 0.005135011152966777 9.341493973600463e-11 10.029583662034877 0.3292360169699745 SQDFGNLFSFPSYSQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQDFGNLFSFPSYSQK 16 0 Q02880;Q02880-2 Q02880 TOP2B DNA topoisomerase 2-beta 0 3490780.0 478080.0 1192400.0 1820300.0 False True 654839.0956262124 1139715.8252604983 1390382.6302552815 1.0 1.7404517122952254 2.123243159337761 19.320780931530365 -9.722127352796686 0.1648622250128063 8.90663847916025e-13 2.6287272747414883 0.9996773946758379 0.008374354894668857 1.202843147125352 0.07064600194631596 0.8408446954869847 0.289420840679463 1.8961498114726486e-10 9.722127352796686 2.6287272747405974 SQDLAK(ub)IMADIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQDLAKIMADIR 12 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 11817800.0 1969000.0 3763500.0 6085300.0 True False 2581378.0678231223 3202000.470008103 5455651.530319422 1.0 1.2404229004348644 2.1134647413039254 21.299710022894512 -6.94709846523665 0.5898382362380293 0.9899041151375927 2.407901636525151 0.9989534730998791 0.01547630871514071 0.0846721911261654 0.04094850364057641 0.01604752840441817 0.07313563752868772 1.1295397911975218e-07 6.94709846523665 1.4179975213875584 up SQDLAK(ub)IMADIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQDLAKIMADIR 12 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 43192100.0 4651000.0 5888600.0 32652500.0 True False 4503356.550828682 8239948.688643327 24099830.6959972 1.0 1.8297349089818478 5.351526228044832 22.1025692761286 -6.943513763185891 0.6260204745828043 0.9615648387444808 6.4082113799545475 0.9985888713612348 0.0708633865079823 0.08619955445564036 0.047579868380924296 0.07097788712423389 0.29874120643141877 1.1389016884766848e-07 6.943513763185891 5.446646541210066 SQDLAK(ub)IMADIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQDLAKIMADIR 12 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 162900400.0 0.0 29275400.0 133625000.0 True False 0.0 24050976.140255816 107213960.18008186 0.0 SQDLAK(ub)IMADIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQDLAKIMADIR 12 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 15188000.0 1969000.0 2882000.0 10337000.0 True False 2696992.5102242515 2754663.7105004694 7895613.497197638 1.0 1.0213835225932544 2.927562263248973 21.362920084417404 -6.909351001342729 0.9001433776936587 0.9397627154661573 3.1705143229072315 0.9906743386155961 0.08726630818904112 0.10484873590518468 0.14110684761290118 0.0712176273936041 0.19571995029970168 1.2321086276312907e-07 6.909351001342729 2.230751607441074 up SQDLAK(ub)IMADIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQDLAKIMADIR 12 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 20953930.0 4651000.0 7061030.0 9241900.0 True False 3867512.574235556 7022990.829885284 11174338.560282463 1.0 1.8158934703071865 2.889283058760619 21.882974551562878 -6.967345341328955 0.3152164738164942 0.8444988428391813 3.895057282843907 0.9999536486765176 0.005267355480210368 0.07717387231609488 0.012099165632606051 0.01659790645355781 0.09482713951869752 1.0780891087759715e-07 6.967345341328955 3.0505584400047256 SQDLAK(ub)IMADIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQDLAKIMADIR 12 1 P05783;F8VZY9 P05783 KRT18 Keratin, type I cytoskeletal 18 1 151512100.0 0.0 21046100.0 130466000.0 True False 0.0 19874866.033991225 106722526.69420633 0.0 SQEGENEEGSEGELVVK(ub)FGETLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQEGENEEGSEGELVVKFGETLPK 24 1 H0Y5Q9;Q92835-3;Q92835-2;Q92835 H0Y5Q9 INPP5D Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 1 31724100.0 11756000.0 10076000.0 9892100.0 True False 17834711.47872261 8277859.075852668 7936922.099138557 1.0 0.46414314499723885 0.4450266609923891 24.088184540987218 SQEGENEEGSEGELVVK(ub)FGETLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQEGENEEGSEGELVVKFGETLPK 24 1 H0Y5Q9;Q92835-3;Q92835-2;Q92835 H0Y5Q9 INPP5D Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1 1 10991500.0 4178900.0 4265800.0 2546800.0 True False 3474940.5066594193 4242819.288704995 3079324.1049272697 1.0 1.2209760945760089 0.8861516043299201 21.728556847453223 -6.728705593739183 1.7277859749716142 1.1331731454519836 0.8863917141332348 0.55331136735172 0.09290308818276455 0.3386780854648545 1.9800841171365575 0.04261955093411491 0.10591947958179669 1.8676453301047062e-07 6.728705593739183 -0.24678143131874875 SQEGRPVQVIGALIGK(ub)QEGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQEGRPVQVIGALIGKQEGR 20 2 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 130686700.0 1942600.0 3894100.0 124850000.0 True False 2947066.2230832367 3199167.430257834 100173342.77630097 1.0 1.085543109007862 33.99086928949261 21.490848048734286 -6.906617454105749 0.9187965550951446 2.2532515244656098e-14 37.94464667607828 0.9899944631921588 1.5536220753097272 0.1053334701900822 0.1494258322591092 1.2584130439419454 3.3961442733216467 1.2398882543816026e-07 6.906617454105749 37.94464667607826 up SQEGRPVQVIGALIGK(ub)QEGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQEGRPVQVIGALIGKQEGR 20 2 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 1 105022000.0 1942600.0 5327400.0 97752000.0 True False 2514733.994370772 5030925.506839025 79962139.02022035 1.0 2.0005795913606543 31.7974542035919 21.261974370826735 -6.914034294134451 0.8677932262228726 0.19098089135139326 36.00020401321373 0.9923577106171296 1.2490649530945723 0.10180966036861651 0.12473630227978187 1.0434897811430999 2.9678244602836936 1.2188933450131826e-07 6.914034294134451 35.80922312186234 up SQEHPASQTSK(ub)PR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQEHPASQTSKPR 13 1 Q12980;B7Z6Q0;B1B1F5;A0A087WTE2;A0A087WTP7;F8WEK7 Q12980 NPRL3;C16orf35 Nitrogen permease regulator 3-like protein 1 4027470.0 415970.0 1095100.0 2516400.0 True False 402765.2600404661 1532379.1408710575 1857279.3496181704 1.0 3.804645764922969 4.611319629283738 18.619579725485686 -9.483040656339062 0.3744294058319663 2.123689287501865e-24 4.762595445031033 0.9983379087193581 0.06309781809538047 0.8351398872633575 0.15270117318478582 1.3273883223698724 0.21873636542397817 3.2882084697664046e-10 9.483040656339062 4.762595445031033 SQEHPASQTSK(ub)PR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQEHPASQTSKPR 13 1 Q12980;B7Z6Q0;B1B1F5;A0A087WTE2;A0A087WTP7;F8WEK7 Q12980 NPRL3;C16orf35 Nitrogen permease regulator 3-like protein 1 2870870.0 504530.0 761340.0 1605000.0 True False 691068.3754105847 727701.4813852978 1225932.0560125948 1.0 1.0530093797924818 1.7739663680663023 19.398468934667665 -6.92166686299997 0.8122671914731547 0.985028187974361 1.8948052124853911 0.9946316059567173 0.025865592284928247 0.09720082280761459 0.10060422559251078 0.022484879902459454 0.06846476287241024 1.1976588747690406e-07 6.92166686299997 0.9097770245110302 SQEHPASQTSK(ub)PR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQEHPASQTSKPR 13 1 Q12980;B7Z6Q0;B1B1F5;A0A087WTE2;A0A087WTP7;F8WEK7 Q12980 NPRL3;C16orf35 Nitrogen permease regulator 3-like protein 1 3122120.0 415970.0 622050.0 2084100.0 True False 345897.4855955203 618698.893182742 2519875.6742103538 1.0 1.7886770472400182 7.285036113725912 18.399985000919962 -6.932755519678844 0.7238149538577252 0.9243626540719895 8.496902884053576 0.9970526437923624 0.15176675441986018 0.09123215535689216 0.07085421666614368 0.14060655184212742 0.49000861407359425 1.167466641980903e-07 6.932755519678844 7.572540229981586 SQEIIPFPSTK(ub)MMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQEIIPFPSTKMMR 14 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 18564000.0 6657400.0 6947700.0 4958900.0 True False 8727915.870353311 5911130.24192249 4445800.597127663 1.0 0.6772670967190709 0.5093771139830767 23.057205764706016 -13.9999999999995 0.08277556070031104 2.712465868799204 0.03278305455322638 0.9998749671842736 0.002276540766873913 12.231308655046371 0.08174663953237035 3.7886433232508114 0.43139302471529267 1.0000000000011494e-14 13.9999999999995 -2.679682814245978 SQEIIPFPSTK(ub)MMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQEIIPFPSTKMMR 14 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 32736300.0 8411600.0 8732700.0 15592000.0 True False 8144578.362277048 12219712.650428891 11507987.450026426 1.0 1.5003493252672842 1.4129629476373584 22.957408582943337 -10.042487732379051 4.7565769621389675 0.9999874642164882 1.4566561364620942 0.9732697285030649 0.03567533931335316 24691712.363065906 0.9023589557719324 3444.8236626520993 0.01221261754992311 9.068015788649861e-11 10.042487732379051 0.45666867224560603 SQEIIPFPSTK(ub)MMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQEIIPFPSTKMMR 14 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 19900000.0 6657400.0 6177000.0 7065600.0 True False 9118820.689470263 5904079.715392571 5396850.800599748 1.0 0.6474608851789534 0.5918364867983017 23.120415826228907 -13.999999999999998 0.2599121249354272 3.579571687316755 0.5714890139552031 0.9995621540211374 0.0037817636547589823 14.413184888075069 0.16132991018410137 19.526946428783045 0.0243294475934492 1.0000000000000041e-14 13.999999999999998 -3.008082673361552 SQEIIPFPSTK(ub)MMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQEIIPFPSTKMMR 14 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 27522100.0 8411600.0 12775000.0 6335500.0 True False 6994618.097062956 12706178.539361043 7660223.75795773 1.0 1.8165650165655756 1.0951596858696635 22.737813858377613 -10.280520323216596 4.521163516245424 0.999745347197916 1.4558623512202966 0.3474338018462212 0.2945124929972313 0.0007563860117475056 0.00012036776904344314 0.2853177386660426 0.09505349838441196 5.2417907098447894e-11 10.280520323216596 0.45611700402238065 SQEIIPFPSTK(ub)MMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQEIIPFPSTKMMR 14 1 O95551;O95551-2;O95551-3;X6R5A3 O95551 TDP2 Tyrosyl-DNA phosphodiesterase 2 1 31119500.0 7367100.0 8996400.0 14756000.0 True False 9536856.17725156 8495742.431528818 12070559.409345802 1.0 0.8908326049619862 1.2656748917046616 23.185082329791587 -6.828760279255139 1.3333558938064454 0.9416147712135455 1.2755143518670626 0.9033846765346919 0.04892844276510603 0.18234879119500927 0.6344473851300491 0.028814947185148765 0.06631826163089435 1.4833366275318773e-07 6.828760279255139 0.3338995806535171 SQEK(ub)ANLGENMEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQEKANLGENMEK 13 1 Q8WWK9-6;Q8WWK9-5;Q8WWK9 Q8WWK9-6 CKAP2 Cytoskeleton-associated protein 2 1 7964100.0 1948900.0 2892900.0 3122300.0 True False 2522889.4685623357 2731907.5719365194 2554073.4375034147 1.0 1.0828486962979367 1.0123604182147738 21.26664557046594 -10.283228376796613 4.4333181645158835 0.9999683792713566 1.0476045572567885 0.37816273008171675 0.02877671902666013 8.999804512564238e-06 1.4550389340498496e-06 0.027881443432887794 0.009287646128856592 5.209207092631997e-11 10.283228376796613 0.04763617798543185 SQELLQSK(ub)NEELLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQELLQSKNEELLK 14 1 A0A0A0MR27;J3QT39;Q49A88-2;Q49A88-3;Q49A88-6;Q49A88;Q49A88-4;Q49A88-5;H7C5T3;C9JU82 A0A0A0MR27 CCDC14 Coiled-coil domain-containing protein 14 1 5069580.0 705780.0 1840400.0 2523400.0 True False 683375.40022444 2575281.3175592124 1862445.8396226706 1.0 3.768472375086104 2.7253627201257027 19.38231878978817 -10.349870556504824 6.073696722912371 0.9997471465851573 3.246917547605834 0.8608524285307075 0.4258477334039389 0.0014583129880336614 0.00015609809945048975 0.4123664844838345 0.13744176495780186 4.468167481211046e-11 10.349870556504824 2.2471704010206768 SQEQLAAELAEYTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQEQLAAELAEYTAK 15 0 P15311;E7EQR4 P15311 EZR Ezrin 0 26893800.0 2866800.0 11548000.0 12479000.0 False True 3758402.56213069 9825083.413751429 11187792.787020534 1.0 2.614164728586566 2.9767414751542796 21.841688171283085 -10.11174676083755 0.34880813543877826 3.932339083894667e-24 3.0513543562713057 0.9989069879550542 0.028406795817921347 1.4986608087624869 0.15849266397784317 1.5834257829444616 0.10763067661883546 7.731312701777786e-11 10.11174676083755 3.0513543562713057 SQEQLAAELAEYTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQEQLAAELAEYTAK 15 0 P15311;E7EQR4 P15311 EZR Ezrin 0 25748600.0 7095100.0 2965500.0 15688000.0 False True 6869869.934161393 4149639.6148782056 11578842.170088157 1.0 0.6040346694547359 1.685452895186667 22.71185135437677 -6.807586310365304 1.4244806412932471 0.7835803776901655 1.7033791320560763 0.8534883892771092 0.17099364647076867 0.21010096715248408 0.8406642162391036 0.09439672355039097 0.21862511307597293 1.5574484814953986e-07 6.807586310365304 0.9197987543659107 SQEQLAAELAEYTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQEQLAAELAEYTAK 15 0 P15311;E7EQR4 P15311 EZR Ezrin 0 31283800.0 2866800.0 15707000.0 12710000.0 False True 3926733.432356976 15013012.80389689 9708159.770666732 1.0 3.823282904866171 2.472324627556784 21.904898232805976 -9.622932375891198 14.02693009578487 1.0000000000027727 3.1478037662114775 0.7711728023817449 0.5515264071995628 0.0 8.738581378500024e-19 0.5340131475193791 0.17800438250645978 2.382690449836218e-10 9.622932375891198 2.147803766208705 SQEQLAAELAEYTAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQEQLAAELAEYTAK 15 0 P15311;E7EQR4 P15311 EZR Ezrin 0 12065000.0 7095100.0 2267200.0 2702700.0 False True 5899890.016224197 2254986.1435960345 3267822.0741271134 1.0 0.3822081661514052 0.5538784731818526 22.492256629811045 -10.77280069826731 10.621249270609395 1.002054640523123 0.46804331966696233 0.9275503033221209 0.07008410936858663 0.003414381317736085 7.303698149065088e-05 0.06794915289864592 0.02261954903485961 1.6873271777054075e-11 10.77280069826731 -0.5340113208561607 SQESGYYDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQESGYYDR 9 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 0 8131900.0 1106100.0 3504400.0 3521400.0 False True 1450107.8114876356 2981557.1800442087 3157039.307653985 1.0 2.056093454862153 2.1771066141732205 20.46772873392057 -10.820153427012293 0.4083172969040891 1.0774808653209423e-11 2.1854577922425213 0.9994781824828071 0.012076891137442562 2.4693119912792536 0.19780734390220667 2.428920523599278 0.030182723835174594 1.513026633847787e-11 10.820153427012293 2.1854577922317464 SQESGYYDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQESGYYDR 9 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 0 8188400.0 1106100.0 2966700.0 4115600.0 False True 1515055.0612285645 2835621.3844350274 3143580.043442645 1.0 1.8716292608769018 2.074894915629999 20.53093879544346 -10.799081769436993 0.2876433639416685 4.809684978432765e-13 2.1450169917056128 0.9991751700112579 0.013390466260444532 2.5526206995790988 0.1454250993901173 1.8260972660580035 0.07708033557377329 1.5882476834447448e-11 10.799081769436993 2.145016991705132 SQETECTYFSTPLLLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQETECTYFSTPLLLGK 17 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 44636700.0 6136700.0 19912000.0 18588000.0 False True 8045273.127887332 16941207.2163681 16664692.068686387 1.0 2.105734255017992 2.0713643656076215 22.939709968962752 -10.144239744920762 6.015849349600287 0.9999922603193895 2.0885493103128225 0.9992528689316567 0.01403144859527183 1.4565804806269053e-06 2.0716485874721785e-07 0.013585988091074478 0.004528630561046217 7.173981544278462e-11 10.144239744920762 1.0885570499934332 SQETECTYFSTPLLLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQETECTYFSTPLLLGK 17 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 26157700.0 16151000.0 4113300.0 5893400.0 False True 15638295.345610417 5755762.140576124 4349741.741789747 1.0 0.3680555977088471 0.2781467957766059 23.898579924269374 -13.999999999999998 0.2746800151158734 6.002486370681372 0.2496307095043316 0.9995934745863941 0.006476130148214194 15.117812010539902 0.1659547967830688 42.34948666147131 0.036487888194191506 1.0000000000000041e-14 13.999999999999998 -5.7528556611770405 SQETECTYFSTPLLLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQETECTYFSTPLLLGK 17 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 127725600.0 6997500.0 111400000.0 9328100.0 False True 10615719.085774185 91519799.62782721 7484396.946348537 1.0 8.621158763561313 0.7050296721187883 23.33969876379616 -6.6548047935190775 1.991223343099761 5.926490337187054 0.7381944805322759 0.21376984473417915 3.248990729002977 0.496906192077917 3.781701368274375 1.3207603989338137 3.600182300620688 2.2140896739735664e-07 6.6548047935190775 -5.188295856654777 SQETECTYFSTPLLLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQETECTYFSTPLLLGK 17 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 48988700.0 6136700.0 23292000.0 19560000.0 False True 8405603.828081852 22262882.423656106 14940330.8508451 1.0 2.648576221172735 1.7774250555244722 23.002920030485644 -10.302134169854208 9.493504394915803 0.9999997126697117 2.2130006383486034 0.7210660870512973 0.35564597411150484 2.164643471003456e-06 1.5890758550699037e-07 0.3443528158063228 0.11478424457329776 4.9873038713547116e-11 10.302134169854208 1.2130009256788918 SQETECTYFSTPLLLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQETECTYFSTPLLLGK 17 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 22494100.0 16151000.0 0.0 6343100.0 False True 13430272.110616742 0.0 7669412.882819295 1.0 0.0 0.5710541692417803 23.67898519970365 -10.150247542257942 6.152530554264663 1.000004225302534 0.2855270846208857 0.6760776491792111 0.23313188835523552 1.3511822358030456e-05 1.8659288455072136e-06 0.22573031480458694 0.07524299342247362 7.075423793890659e-11 10.150247542257942 -0.7144771406816484 SQETECTYFSTPLLLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQETECTYFSTPLLLGK 17 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 24551400.0 6997500.0 8784200.0 8769700.0 False True 9058401.691346372 8295351.548067614 7173704.584720788 1.0 0.9157632693626614 0.7919393320318238 23.11082508588861 -6.965591494064854 0.34775415912455215 1.0122795697770164 0.6912591496752365 0.9999248167122909 0.0007409118185498415 0.07776084740907835 0.014155602521610935 0.0017096318551817337 0.010659051258210758 1.0824516479092384e-07 6.965591494064854 -0.3210204201017799 SQFEELCAELLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQFEELCAELLQK 13 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 8060200.0 1261900.0 3770300.0 3028000.0 False True 1654363.1202569848 3207785.9365142887 2714691.6066269884 1.0 1.938985400022698 1.640928508008142 20.657844499296985 -10.045520494648619 4.940636324115971 0.9999874788123723 1.7899569540199398 0.9035293884297462 0.12168121666100529 2.0374474035433013e-05 3.935917950710387e-06 0.11781959253785815 0.03927244380110627 9.004912669595794e-11 10.045520494648619 0.7899694752075676 SQFEELCAELLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQFEELCAELLQK 13 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 10585900.0 1261900.0 4486500.0 4837500.0 False True 1728458.5315652555 4288271.595128504 3694982.1314398297 1.0 2.480980316747973 2.137732588871387 20.721054560819876 -10.452845891242712 5.6705381850323455 0.9989662889449504 2.3093564528096686 0.9509844117806463 0.140130298111228 0.0018324014983442528 0.00017680928062528808 0.13576273856394622 0.04522685924032128 3.52495931514566e-11 10.452845891242712 1.3103901638647182 SQFK(ub)GPAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQFKGPAPR 9 1 O15145;C9JZD1;F8VR50 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 1 4415600.0 1039800.0 1646700.0 1729100.0 True False 1363187.8694375246 1401018.7787863254 1550189.3186983892 1.0 1.0277517943028722 1.1371795138831633 20.378552971986924 -6.945202967914389 0.6092275669555923 0.9987882327531722 1.1718342885175064 0.9987691096284022 0.0020776604235031434 0.0854708831212741 0.044386746705058204 0.00211343773704947 0.009224754240088211 1.1344804912863203e-07 6.945202967914389 0.17304605576433418 SQFK(ub)GPAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQFKGPAPR 9 1 O15145;C9JZD1;F8VR50 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 1 8216200.0 1450000.0 3463700.0 3302500.0 True False 1403970.5436898728 4846773.472956875 2437476.1771236723 1.0 3.45219028614285 1.736130567752206 20.42108123650629 -9.454234412097609 8.641831810206588 1.0000050265996794 2.5941604269475764 0.5350212869640923 0.7005784463730658 0.0 0.0 0.6783321638758923 0.22611072129196405 3.5137073564561216e-10 9.454234412097609 1.594155400347897 SQFK(ub)GPAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQFKGPAPR 9 1 O15145;C9JZD1;F8VR50 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 1 3976600.0 1039800.0 1159900.0 1776900.0 True False 1424242.1595384357 1108651.782723626 1357232.816404225 1.0 0.7784152261599352 0.9529508779911929 20.441763033509815 -9.909492584630664 5.359346257510646 1.0000001921869845 0.8656830521643012 0.44123006049423685 0.07125388148830898 1.6360470747785222e-07 3.337743439158483e-08 0.0689913727803611 0.022997091362608694 1.2317070163615308e-10 9.909492584630664 -0.13431714002268336 SQFLK(ub)HVEEFSPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQFLKHVEEFSPR 13 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 9695900.0 1879200.0 4173200.0 3643500.0 True False 2463649.398198685 3550574.8270061943 3266505.570919888 1.0 1.4411851092132761 1.325880855168847 21.232365530117793 -10.124157236895392 5.170064912062423 0.9999886332560809 1.3835329821915294 0.9365163539101408 0.04707276459848111 6.1676322264362345e-06 1.0448072498186257e-06 0.0455793583801731 0.015192669445586948 7.513508172045742e-11 10.124157236895392 0.38354434893544853 SQFLK(ub)HVEEFSPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQFLKHVEEFSPR 13 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 11224800.0 3028600.0 3668200.0 4528000.0 True False 2932458.7507718257 5132931.389410298 3341980.9629117297 1.0 1.7503848564141973 1.139651482576564 21.483679384150687 -10.130409667333097 4.468360015016962 0.999953604140692 1.4450181690713284 0.4144962447335172 0.2493308559419437 28351817.63152103 64277629.70202428 9438.730675009936 0.08535259292591853 7.406112975830312e-11 10.130409667333097 0.4450645649306364 SQFLK(ub)HVEEFSPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQFLKHVEEFSPR 13 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 27135200.0 5278600.0 5099600.0 16757000.0 True False 8008022.117351578 4189536.5366433403 13444971.605145983 1.0 0.523167453242363 1.6789378710647866 22.93301452808217 -6.7946749845242795 1.4776470941991398 0.7351103768531391 1.6928556474469207 0.8161081762423616 0.2033664377342785 0.22844913809211206 0.9852350762549631 0.10830391206038537 0.25272534163271815 1.6044456697987722e-07 6.7946749845242795 0.9577452705937817 SQFLK(ub)HVEEFSPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQFLKHVEEFSPR 13 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 9288500.0 1879200.0 2584500.0 4824800.0 True False 2573991.023470499 2470308.2442014082 3685281.609875122 1.0 0.9597190594980025 1.431738330192883 21.295575591640684 -6.886147067689539 1.044883517102696 0.9722462207480326 1.469402571979872 0.978316281572302 0.03146102376533195 0.12232589747316085 0.24054338965177174 0.023049666128556353 0.05672241598471549 1.299729368517188e-07 6.886147067689539 0.49715635123183943 SQFLK(ub)HVEEFSPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQFLKHVEEFSPR 13 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 11531900.0 3028600.0 4839600.0 3663700.0 True False 2518415.089729051 4813528.114214608 4429762.73096515 1.0 1.9113323033386374 1.7589486137655468 21.264084659584963 -10.14857487678094 4.6116586574914935 0.9999035705217602 1.835140458564063 0.9756382759230051 0.062210380821479595 43512066.01166036 8.807507491537725 45704.49719569429 0.021296268045367717 7.102727012160496e-11 10.14857487678094 0.8352368880423028 SQFLK(ub)HVEEFSPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQFLKHVEEFSPR 13 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 1 27212900.0 5278600.0 5677300.0 16257000.0 True False 6833251.756761843 5361353.264252215 13298392.810906388 1.0 0.784597649127575 1.9461294979724646 22.704140850174618 -6.858812463253103 1.1918002415027098 0.8834864524950541 2.001091178952964 0.9521695165762457 0.11033586421276839 0.14803326190138197 0.40023227997648775 0.07224302516460655 0.1684090539175342 1.3841639586756152e-07 6.858812463253103 1.11760472645791 SQFYFLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQFYFLTK 8 0 Q8IWA0 Q8IWA0 WDR75 WD repeat-containing protein 75 0 11891300.0 3011800.0 3527300.0 5352200.0 False True 3948498.9663126897 3001040.5893077124 4798405.685927658 1.0 0.7600459351545019 1.2152480542267066 21.912872882000794 -6.763495833800835 1.5994356427848857 0.8612262136473415 1.217196797970361 0.7050120434617995 0.10098198617911901 0.2770921155643534 1.3978376405763582 0.04979805039452815 0.1192571977985702 1.7238686280678151e-07 6.763495833800835 0.35597058432301953 SQFYFLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQFYFLTK 8 0 Q8IWA0 Q8IWA0 WDR75 WD repeat-containing protein 75 0 8581500.0 3011800.0 2161000.0 3408700.0 False True 4125343.8508346407 2065519.874528631 2603635.264380149 1.0 0.5006903543593668 0.631131696780471 21.976082943523686 -10.25234092862022 8.2741881950904 1.0000002826876868 0.5659110255699475 0.936572761921507 0.05325245504922715 2.7773354072422965e-07 2.5071731376431316e-08 0.05156150169241735 0.017187155962526318 5.593183546039588e-11 10.25234092862022 -0.43408925711773927 SQFYFLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQFYFLTK 8 0 Q8IWA0 Q8IWA0 WDR75 WD repeat-containing protein 75 0 5948500.0 2364500.0 1766600.0 1817400.0 False True 1966186.5151107262 1757082.975157354 2197409.9372918243 1.0 0.8936502013688175 1.1175999430390136 20.906968753496074 -6.777577670184546 1.545332918008517 0.9395916994604901 1.119239969245804 0.7586984473877219 0.04493012028176601 0.2543667252325092 1.1996423461497763 0.022903923336986834 0.05415356270461399 1.6688693162452353e-07 6.777577670184546 0.17964826978531379 SQGLSQLYHNQSQGLLSQLQGQSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQGLSQLYHNQSQGLLSQLQGQSK 24 0 D3DQV9;P78344 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 7803800.0 1794300.0 3330200.0 2679300.0 False True 2352344.6760259178 2833347.141017928 2402071.7376603964 1.0 1.2044778853601599 1.0211393602907242 21.165668035094104 -10.900231520548656 2.8799738109610544 0.9417925494051772 1.1128086227440688 0.33545806763575037 0.07484763976485086 56672884.975599654 15087970.439709056 21813310.29459774 0.02739143019428488 1.2582544628457857e-11 10.900231520548656 0.17101607333889157 SQGLSQLYHNQSQGLLSQLQGQSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQGLSQLYHNQSQGLLSQLQGQSK 24 0 D3DQV9;P78344 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 20686300.0 3291100.0 2248200.0 15147000.0 False True 3186625.831957057 3145917.984208119 11179546.299740277 1.0 0.9872254070933902 3.508270782100072 21.603598199650932 -6.90575756888759 0.9241273674018858 0.9110891656198877 3.8061703915651783 0.9892200599988942 0.12307931178339691 0.10729115524426681 0.15447386024007578 0.09869904117896453 0.26507848235235465 1.2423456140800955e-07 6.90575756888759 2.8950812259452907 up SQGLSQLYHNQSQGLLSQLQGQSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQGLSQLYHNQSQGLLSQLQGQSK 24 0 D3DQV9;P78344 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 10092600.0 1794300.0 3294800.0 5003500.0 False True 2457701.19913427 3149224.8415534175 3821776.3503171443 1.0 1.2813701041700016 1.5550207452652796 21.228878096616995 -6.971465792029357 0.22038035327152083 0.8744089715665412 1.9697124552161722 0.9999916687272805 0.0006540129481498022 0.07582988357541125 0.007304176081860153 0.0075578908655566214 0.027713580763061664 1.0679089049543278e-07 6.971465792029357 1.095303483649631 SQGMALSLGDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQGMALSLGDK 11 0 P53618 P53618 COPB1 Coatomer subunit beta 0 15707800.0 3785400.0 3513000.0 8409400.0 False True 4962696.057865741 2988874.093566749 7539275.956660825 1.0 0.6022682144374857 1.519189543093471 22.242692668279687 -6.788811509545666 1.501048224408874 0.7773642742966452 1.528628906087849 0.797461195847081 0.1689572828407869 0.23712715073861482 1.0555088966128992 0.0886031236085986 0.20762531255624211 1.6262544219220372e-07 6.788811509545666 0.7512646317912038 SQGMALSLGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQGMALSLGDK 11 0 P53618 P53618 COPB1 Coatomer subunit beta 0 13726100.0 3785400.0 2829800.0 7110900.0 False True 5184964.676588561 2704770.0791027835 5431451.873582532 1.0 0.5216564138451146 1.0475388382310342 22.30590272980258 -6.667291675422957 1.9470610866883686 0.6939674627117085 1.0453865518216834 0.26709252810992035 0.2033174984943558 0.46735057440452193 3.4131349207236164 0.08414640034178485 0.22560788979155758 2.151336395811141e-07 6.667291675422957 0.3514190891099749 SQGMALSLGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQGMALSLGDK 11 0 P53618 P53618 COPB1 Coatomer subunit beta 0 5977800.0 2474700.0 1896300.0 1606800.0 False True 2057822.6977984803 1886084.2555139202 1942774.4509962082 1.0 0.9165436155076475 0.9440922452039459 20.972687254167266 -10.450333671323747 8.899135242038103 1.0000008944694423 0.9303179303557967 0.8950750546414736 0.011246680978135809 1.9958712102694384e-07 1.2335628041262331e-08 0.010889691742063518 0.003629850677368976 3.5454088845465504e-11 10.450333671323747 -0.0696829641136456 SQGMASLNLPAVSWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQGMASLNLPAVSWK 15 0 P35221;P35221-2;P35221-3;E5RGY7 P35221 CTNNA1 Catenin alpha-1 0 2788200.0 1494600.0 1293600.0 0.0 False True 1447154.7411026778 1810141.2260348806 0.0 1.0 1.2508276928669153 0.0 20.464787763678622 -6.897976358387812 1.3025781784434205 1.130644469484683 9.491912534080204e-21 0.9453509482520668 0.12631069864210798 0.13588382520955036 0.46283694451819185 0.07914006579583902 0.15808367413298766 1.2648051975748244e-07 6.897976358387812 -1.130644469484683 down SQGMASLNLPAVSWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQGMASLNLPAVSWK 15 0 P35221;P35221-2;P35221-3;E5RGY7 P35221 CTNNA1 Catenin alpha-1 0 4660700.0 1494600.0 1202200.0 1963900.0 False True 1242826.1220065507 1195723.5099819833 2374542.4099523593 1.0 0.9621004006992387 1.9105990515540867 20.2451930391129 -6.897590807841214 0.9763566031664722 0.9579160202748861 2.0054345356822627 0.9853296015962845 0.05310769800442052 0.11320102867620513 0.18758252152217858 0.040972736453305 0.10537395566319507 1.2659285433156406e-07 6.897590807841214 1.0475185154073765 SQGPSLDLSALK(ub)SK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQGPSLDLSALKSK 14 1 O95466;O95466-2;O95466-3;K7EK60;K7EJE6;A0A0A0MR62 O95466 FMNL1 Formin-like protein 1 1 9466400.0 3501900.0 3520600.0 2443900.0 True False 3390734.101343147 4926393.939686463 1803769.2745715484 1.0 1.4528989276201298 0.5319701340948659 21.693166223131797 -6.772993707818346 1.5631268202884492 1.2587760100146113 0.5262099766339309 0.7418386390255534 0.1910361626846824 0.2616131041292978 1.261929937130849 0.09631145782050356 0.22862505099002858 1.6865774608244268e-07 6.772993707818346 -0.7325660333806804 SQGPSLDLSALK(ub)SK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQGPSLDLSALKSK 14 1 O95466;O95466-2;O95466-3;K7EK60;K7EJE6;A0A0A0MR62 O95466 FMNL1 Formin-like protein 1 1 10013200.0 3501900.0 4068000.0 2443300.0 True False 2911985.0104742004 4046084.876565226 2954182.7334571998 1.0 1.3894593763401082 1.0144910508918203 21.473571498566074 -9.354473929495148 7.775451346935917 1.000000000432893 1.2019752136166122 0.27894293125363656 0.15308017784478517 0.0 0.0 0.14821924485574597 0.04940641495191531 4.421056554852071e-10 9.354473929495148 0.20197521318371914 SQGQDVTSSVYFMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQGQDVTSSVYFMK 14 0 A0A087WTB8;P15374;Q5TBK7 A0A087WTB8 UCHL3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase isozyme L3 0 7925700.0 2349400.0 2475700.0 3100600.0 False True 3080086.151621961 2106335.2102030143 2779779.6550553623 1.0 0.6838559399040922 0.9025006179101651 21.554539273744194 -10.094122584459384 5.277469295182182 1.0000034265408264 0.7931782802379949 0.5440109393749384 0.08926131601575073 3.598788779637723e-06 6.176605442278001e-07 0.0864283295645215 0.02880896586568855 8.051511462348038e-11 10.094122584459384 -0.20682514630283155 SQGQDVTSSVYFMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQGQDVTSSVYFMK 14 0 A0A087WTB8;P15374;Q5TBK7 A0A087WTB8 UCHL3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase isozyme L3 0 6418500.0 2349400.0 1968300.0 2100800.0 False True 3218036.6701477165 1881333.9977023143 1604634.3073341174 1.0 0.5846216779176591 0.49863767004881904 21.617749335267085 -13.999999999999998 0.22138962853921806 3.5219508005466476 0.45325260633222864 0.999499322723737 0.00489830015946368 13.037781494041301 0.1490466986314265 14.38556008267911 0.04715322336003634 1.0000000000000041e-14 13.999999999999998 -3.068698194214419 SQGQLNEK(ub)PLPEGWEMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQGQLNEKPLPEGWEMR 17 1 A0A590UJQ1;Q96J02-3;Q96J02-2;Q96J02;A0A590UK44;A0A590UJW8;A0A590UK95 A0A590UJQ1 ITCH E3 ubiquitin-protein ligase Itchy homolog 1 14273600.0 5780000.0 3873900.0 4619700.0 True False 5596517.063812043 5420768.472121624 3409661.981970694 1.0 0.9685967915961811 0.6092471340823926 22.416097828992033 -6.924091223455448 0.7937955674415584 1.006821958939493 0.5454710580440418 0.9952439149407208 0.012224973342008798 0.09582408413683628 0.09357629389724403 0.01076809120060796 0.03363293759842252 1.1909918141966862e-07 6.924091223455448 -0.46135090089545105 SQHQTK(ub)EEQSQITSQVTGQIGWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQHQTKEEQSQITSQVTGQIGWR 23 1 E9PFW3;Q96CW1 E9PFW3 AP2M1 AP-2 complex subunit mu 1 6248800.0 2094100.0 1540900.0 2613800.0 True False 2027623.9417523867 2156189.4056873433 1929167.367680804 1.0 1.063406956925081 0.9514423892694368 20.95135867350107 -6.75306107945572 1.6383892936858888 1.037146258233921 0.9511651813870464 0.662076397236179 0.026649170248517103 0.2947418661194993 1.5575171097630134 0.012843767916448492 0.031083201089725242 1.7657894614544408e-07 6.75306107945572 -0.08598107684687462 SQHSGNAQVTQTK(ub)FLPNAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQHSGNAQVTQTKFLPNAPK 20 1 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 1 6709100.0 2246100.0 1783700.0 2679300.0 True False 2174798.784952982 2495940.711872619 1977510.9527229217 1.0 1.1476651215466722 0.9092845583715344 21.052450496547998 -6.7391576183446915 1.689728765531267 1.0879471744945088 0.9091695481481681 0.6011343345318405 0.06204416075638132 0.3193639731174182 1.7900748557794883 0.029051356991605132 0.07135686465407878 1.8232338765945277e-07 6.7391576183446915 -0.17877762634634076 SQHSGNAQVTQTK(ub)FLPNAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQHSGNAQVTQTKFLPNAPK 20 1 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 1 6414300.0 2246100.0 2737000.0 1431200.0 True False 1867731.6691013752 2722255.2377480334 1730457.3028788723 1.0 1.457519451419805 0.9265020942282625 20.832855771982274 -6.678667085905145 1.906095745702838 1.2898073353824053 0.928515672191846 0.31832943771927713 0.19396146974757428 0.4414536390632974 3.0996517072883143 0.08167705690295604 0.2158279555439445 2.09571834047178e-07 6.678667085905145 -0.3612916631905593 SQICDNAALYAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQICDNAALYAQK 13 0 P55060-3;P55060 P55060-3 CSE1L Exportin-2 0 12425300.0 2145600.0 4748300.0 5531400.0 False True 2812902.3780199545 4039872.1487284326 4959063.7889354415 1.0 1.4361935132537949 1.762970456310753 21.42362805401007 -6.974307541397294 0.11572973097168734 0.3721820690092275 2.835353548690864 0.9999995266170583 0.00021496381235638478 0.07492803127559625 0.0034350438715960215 0.024205305249929417 0.0482865247261616 1.0609439939928281e-07 6.974307541397294 2.463171479681636 SQICDNAALYAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQICDNAALYAQK 13 0 P55060-3;P55060 P55060-3 CSE1L Exportin-2 0 11073300.0 2145600.0 4977300.0 3950400.0 False True 2938886.3026598035 4757386.428269942 3017396.8810418453 1.0 1.618771853802009 1.0267143980054576 21.48683811553296 -10.24581939440476 3.894573568491439 0.9996299504077012 1.3227431259718208 0.28377517312131784 0.2417064444275617 172026925.33347216 258736344.3946421 738756.4045146699 0.08845548297183885 5.677806734492059e-11 10.24581939440476 0.32311317556411956 SQIDVALSQDSTYQGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQIDVALSQDSTYQGER 17 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 3305700.0 1531200.0 1774500.0 0.0 False True 2007418.0281618934 1509751.5169468229 0.0 1.0 0.7520862599451882 0.0 20.936909646591623 -7.330525240149894 0.7995791301720152 0.9892054589609388 1.6679810585308899e-18 0.9879915238642523 0.046593908472001434 0.1070194737903263 0.13764961500840886 0.03989814278878629 0.07086384511870679 4.6716979959867137e-08 7.330525240149894 -0.9892054589609388 down SQIFSTASDNQPTVTIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQIFSTASDNQPTVTIK 17 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 226125000.0 41819000.0 81916000.0 102390000.0 False True 54825113.97577202 69694452.10606712 91795664.99423279 1.0 1.271213993952955 1.6743360539988765 25.7083335703281 -6.965408832741316 0.3509695421135681 0.9614751099556724 1.997697890102814 0.9999213212735738 0.002457425390245809 0.0778225540004178 0.014372610488574675 0.0055199841423795755 0.03462727295391145 1.0829070155112287e-07 6.965408832741316 1.0362227801471415 SQIFSTASDNQPTVTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQIFSTASDNQPTVTIK 17 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 171850000.0 49837000.0 27064000.0 94949000.0 False True 48254951.714394525 37870796.33689549 70079008.49105696 1.0 0.784806429007338 1.4522656432407597 25.52417365731256 -6.819921986551288 1.3721779645187027 0.8840027693984732 1.4668168500160346 0.8842130191476839 0.09465067958500394 0.19358137118217386 0.7162171320636092 0.05420500240493806 0.12493847540031074 1.513833157805829e-07 6.819921986551288 0.5828140806175613 SQIFSTASDNQPTVTIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQIFSTASDNQPTVTIK 17 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 390307000.0 34067000.0 321170000.0 35070000.0 False True 51682129.63130673 263854704.18733674 28138399.128272925 1.0 5.105337300719615 0.5444512315767255 25.623162183647842 -6.669565150486278 1.939157239888437 3.6214628439759564 0.5630304103360755 0.27699257939573363 1.7440448045372259 0.46213290194615303 3.3499208148171133 0.7242016305494529 1.9358117882021029 2.1401038559972788e-07 6.669565150486278 -3.058432433639881 SQIFSTASDNQPTVTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQIFSTASDNQPTVTIK 17 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 228264000.0 41819000.0 72215000.0 114230000.0 False True 57280614.41598168 69024302.51692966 87251226.64069717 1.0 1.205020288638374 1.5232243496388453 25.771543631850992 -6.964684304118749 0.36343511575966536 0.9736341845661428 1.76557330773412 0.9999064816580916 0.002081708839985042 0.07806831713384552 0.015239055424170232 0.004240831291697333 0.027123824638080444 1.0847151249679203e-07 6.964684304118749 0.7919391231679772 SQIFSTASDNQPTVTIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQIFSTASDNQPTVTIK 17 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 99346000.0 49837000.0 32802000.0 16707000.0 False True 41441673.65344599 32625289.115312774 20200356.45555988 1.0 0.7872579999577284 0.48744065272277354 25.304578932746836 -6.966273024436827 0.33548676349502715 1.0342675394054315 0.23053506340006094 0.9999370319696785 0.0016684184623353491 0.07753158002848916 0.013351120329003473 0.0042933635735124655 0.026038291226783254 1.0807543085243039e-07 6.966273024436827 -0.8037324760053706 down SQIFSTASDNQPTVTIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQIFSTASDNQPTVTIK 17 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 111849000.0 34067000.0 39806000.0 37976000.0 False True 44100403.06096414 37590761.10771376 31064757.66666551 1.0 0.8523904204627906 0.7044098355228584 25.394288505740292 -6.971094200697299 0.23056094517126915 1.0597623208383418 0.49280684446995243 0.9999897019335766 0.00038720774959236207 0.07594922958908215 0.0077479657265565535 0.003786633137207498 0.014681447056692892 1.0688230208908895e-07 6.971094200697299 -0.5669554763683893 SQIHDIVLVGGSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQIHDIVLVGGSTR 14 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 473610000.0 109480000.0 150860000.0 213270000.0 False True 143529340.20582828 128352276.04767425 191202866.23029658 1.0 0.8942581068345374 1.3321517813438148 27.09677044124528 -6.842920495742051 1.2686769577180295 0.9437482865564188 1.3474145565071214 0.9293648484243872 0.04958377545262331 0.16542268000984922 0.5159214834160568 0.03062932934740287 0.07063259415516951 1.4357522457401383e-07 6.842920495742051 0.40366626995070254 SQIHDIVLVGGSTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQIHDIVLVGGSTR 14 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 357345000.0 104430000.0 85045000.0 167870000.0 False True 101114926.81209205 119003912.00381607 123899811.00794874 1.0 1.1769173529143546 1.225336504848579 26.591420745936194 -13.99999999999995 0.18182938759629444 0.07683638839385276 1.2630805805406715 0.9994960427715891 0.002174195237786712 12.228900567125098 0.1351909004608858 3.9901817026129787 0.03559705796368781 1.0000000000001145e-14 13.99999999999995 1.1862441921468188 SQIHDIVLVGGSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQIHDIVLVGGSTR 14 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 449620000.0 109480000.0 149340000.0 190800000.0 False True 149957714.58575496 142741664.9986605 145736969.64934802 1.0 0.9518794374332247 0.9718537659228378 27.15998050276817 -10.102240419367158 4.329957479516204 1.0000048615129142 0.9618666016752018 0.8293413981943474 0.008154485471479381 11354971.442001281 0.5095508275005949 559.6644543893613 0.0027914972716471084 7.90241040472982e-11 10.102240419367158 -0.03813825983771246 SQIHDIVLVGGSTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQIHDIVLVGGSTR 14 0 A8K7Q2;P11142;E9PKE3;E9PNE6;P11142-2;E9PN89 A8K7Q2;P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 202885100.0 104430000.0 51062000.0 47393100.0 False True 86838172.03341644 50786918.87098658 57302778.089064226 1.0 0.5848455544578153 0.6598800590483801 26.37182602137047 -10.776211972158332 7.066437325213865 1.0099012650913564 0.6223628067530977 0.9712418346640604 0.03063270822490097 0.00477963871390728 0.00015136694573575308 0.02966795754468455 0.00988666406702271 1.674125562796741e-11 10.776211972158332 -0.3875384583382586 SQIK(ub)NEINIDTLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQIKNEINIDTLAR 14 1 Q8N766-3;Q8N766-2;Q8N766;Q8N766-4;A0A286YEW0 Q8N766-3 EMC1 ER membrane protein complex subunit 1 1 13370400.0 1244900.0 2189900.0 9935600.0 True False 1205381.3309238083 3064338.490177637 7333168.29838909 1.0 2.5422149916899057 6.083691617132419 20.201058194785656 -6.957255558140464 0.4725258036954256 0.9087193554759715 7.862989778592648 0.9996544823348666 0.03955983017216383 0.08069644352624476 0.02486706551531378 0.049202103780604925 0.29224814768208185 1.1034291221754692e-07 6.957255558140464 6.954270423116676 SQIK(ub)NEINIDTLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQIKNEINIDTLAR 14 1 Q8N766-3;Q8N766-2;Q8N766;Q8N766-4;A0A286YEW0 Q8N766-3 EMC1 ER membrane protein complex subunit 1 1 13462400.0 1244900.0 2466800.0 9750700.0 True False 1035189.5084209521 2453510.8587785386 11789526.287857044 1.0 2.370107925959424 11.388761373596651 19.981463470219932 -6.933907139075575 0.7139901284553748 0.8807208502346218 13.439029395625736 0.9972520101690552 0.2415804134225512 0.09065918413606441 0.06810888794372275 0.2254509163782111 0.799227091278529 1.164374969661272e-07 6.933907139075575 12.558308545391114 SQIPLSK(ub)IK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQIPLSKIK 9 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 18551300.0 7265400.0 6855700.0 4430200.0 True False 9525009.758233692 5832856.283309297 3971805.4014791497 1.0 0.612372735709505 0.41698701652728565 23.183289139950936 -12.259342244670497 0.105967213071571 2.359112487390011 9.459755274760652e-21 0.9998221898384169 0.0032308059395373167 6.2693385449772325 0.07962845771389786 2.19853935011187 0.3195061626234788 5.503738047763015e-13 12.259342244670497 -2.359112487390011 SQIPLSK(ub)IK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQIPLSKIK 9 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 29111600.0 10778000.0 9485300.0 8848300.0 True False 10435858.289578935 13272829.755186029 6530664.786689895 1.0 1.2718484083326471 0.6257908650610273 23.31504592299374 -6.792395196897668 1.4867009269775837 1.1514659653005235 0.618455239916074 0.8089951887542466 0.11575164715296356 0.23180569533514714 1.0120964871238503 0.061274404899195646 0.14321517989680896 1.6128901999145251e-07 6.792395196897668 -0.5330107253844495 SQIPLSK(ub)IK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQIPLSKIK 9 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 28191800.0 5408300.0 3977300.0 18806200.0 True False 8204786.499691684 3267519.740213266 15089146.326949708 1.0 0.39824555341397994 1.8390662971567537 22.968034362558164 -6.7932661416254785 1.483296347097783 0.6651046365810366 1.855791190048993 0.8117273381631042 0.25637916518186205 0.23051369753106676 1.0018272941467443 0.13602557633152387 0.31772310982387325 1.6096589117733542e-07 6.7932661416254785 1.1906865534679563 SQIPLSK(ub)IK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQIPLSKIK 9 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 18275200.0 7265400.0 6431600.0 4578200.0 True False 9951614.720052466 6147430.645542957 3496923.450988706 1.0 0.6177319780232154 0.3513925678756854 23.246499201473828 -8.09436454728362 0.1954888230170699 1.2699073897016304 7.485846705277853e-15 0.9998330345322634 0.0034396885582420903 0.09245251466402978 0.0369854111077646 0.09127411398908074 0.10945014859685209 8.047026892697717e-09 8.09436454728362 -1.2699073897016229 down SQIPLSK(ub)IK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQIPLSKIK 9 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 36706900.0 10778000.0 22576200.0 3352700.0 True False 8962384.546357967 22454577.529575143 4053734.068866683 1.0 2.5054244674984383 0.45230530422999915 23.095451198428016 -6.710173753675649 1.794395345846256 1.9253469223967008 0.4570729621034287 0.46594259328147636 0.6343630235666562 0.3747642807579835 2.35229692922848 0.28130760553001893 0.7145538287188622 1.949064656846553e-07 6.710173753675649 -1.4682739602932722 SQIPLSK(ub)IK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQIPLSKIK 9 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 20119100.0 5408300.0 6996300.0 7714500.0 True False 7001150.963531063 6606949.754758024 6310540.15745447 1.0 0.9436947994941931 0.9013575325437233 22.739160684650614 -6.974271855822416 0.1176400246924215 1.078978904434187 0.7649873914108617 0.9999994722841536 2.8778384494313315e-05 0.07493944797353484 0.0034968220840133992 0.0030658488752334117 0.006185879411570905 1.0610311743587673e-07 6.974271855822416 -0.3139915130233254 SQK(ub)AIQDEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQKAIQDEIR 10 1 Q13257 Q13257 MAD2L1 Mitotic spindle assembly checkpoint protein MAD2A 1 23800500.0 7144100.0 5869400.0 10787000.0 True False 9365984.28356281 4993708.398742006 9670864.716210473 1.0 0.5331749709964713 1.0325518838615526 23.158999186472297 -11.823501692273492 13.86642462713862 0.9036475872088037 0.8045770846860735 0.0 0.23368192927134265 0.0 0.0 0.0 0.06785090048735336 1.5014065553563767e-12 11.823501692273492 -0.0990705025227302 SQK(ub)AIQDEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQKAIQDEIR 10 1 Q13257 Q13257 MAD2L1 Mitotic spindle assembly checkpoint protein MAD2A 1 46571200.0 9020200.0 10351000.0 27200000.0 True False 8733858.688407853 14484208.27975191 20075504.017490957 1.0 1.6583973701081625 2.2985835623991115 23.058187758195665 -6.971468719548591 0.22030198696357228 0.7058979286113644 3.2691664056711165 0.999991683096465 0.001528925227764298 0.07582896846270738 0.007300814974629067 0.017691742400931885 0.06484466651234146 1.0679017063518753e-07 6.971468719548591 2.563268477059752 SQK(ub)AIQDEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQKAIQDEIR 10 1 Q13257 Q13257 MAD2L1 Mitotic spindle assembly checkpoint protein MAD2A 1 119977000.0 14760000.0 24526000.0 80691000.0 True False 22391999.10053975 20149143.67748737 64742388.48187838 1.0 0.8998367491449962 2.8913179297295426 24.41647999828364 -6.89506100583704 0.9919758466517337 0.9056125311922525 3.080590976145798 0.9839443957679843 0.1160793791963132 0.11513228494756282 0.19863569773234613 0.08851636198277658 0.2250938903249258 1.2733242031624786e-07 6.89506100583704 2.1749784449535454 up SQK(ub)AIQDEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQKAIQDEIR 10 1 Q13257 Q13257 MAD2L1 Mitotic spindle assembly checkpoint protein MAD2A 1 31047100.0 7144100.0 6123000.0 17780000.0 True False 9785466.83204321 5852465.61394669 13580730.190594368 1.0 0.5980773032495879 1.3878469391080348 23.22220924799519 -6.7683542995223265 1.580672632629892 0.7689826340975465 1.3920231298681538 0.7242449932047808 0.16932048394791044 0.2691047300971756 1.3266717026487669 0.08444520159329694 0.2013262333884111 1.704691126379953e-07 6.7683542995223265 0.6230404957706073 SQK(ub)AIQDEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQKAIQDEIR 10 1 Q13257 Q13257 MAD2L1 Mitotic spindle assembly checkpoint protein MAD2A 1 39475200.0 9020200.0 14723000.0 15732000.0 True False 7500695.962614405 14643684.27671332 19021488.463450544 1.0 1.952310072252174 2.535963137055419 22.83859303362994 -8.711338365334708 0.16690455080171154 3.9074900406261756e-17 3.4175970012074988 0.9998119952570437 0.008680000610960149 0.2711612281914154 0.047800906695561925 0.4998866136226507 0.36494768754256696 1.9438450127330428e-09 8.711338365334708 3.4175970012074988 SQK(ub)AIQDEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQKAIQDEIR 10 1 Q13257 Q13257 MAD2L1 Mitotic spindle assembly checkpoint protein MAD2A 1 125711000.0 14760000.0 21030000.0 89921000.0 True False 19107110.963097163 19859662.013144292 73556300.66737486 1.0 1.0393859150920608 3.8496819749170377 24.18760632037609 -6.909951730558021 0.8960514327543317 0.9128545178844039 4.212505549781614 0.9909036129081658 0.12724610630629168 0.10445028048535358 0.1389359659384293 0.10415319241273635 0.28741832252318156 1.230405516015861e-07 6.909951730558021 3.29965103189721 up SQK(ub)LGVLSSSQNGPPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQKLGVLSSSQNGPPK 16 1 E7EX82;Q8NDX5-3;Q8NDX5-2;Q8NDX5;Q8NDX5-7;C9J6H0;C9JYH7 E7EX82 PHC3 Polyhomeotic-like protein 3 1 11133500.0 1663200.0 2944700.0 6525600.0 True False 1610402.6263896525 4120534.066407637 4816349.596196287 1.0 2.558698054067029 2.990773560146272 20.618989999575 -9.975049769684528 0.3159211877681373 2.0123753339766626e-23 3.121053495020981 0.9988446993349644 0.029061609669392998 1.3661281650975072 0.14074351359941242 1.3976269588436558 0.14411757487350332 1.0591323427851693e-10 9.975049769684528 3.121053495020981 SQK(ub)LGVLSSSQNGPPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQKLGVLSSSQNGPPK 16 1 E7EX82;Q8NDX5-3;Q8NDX5-2;Q8NDX5;Q8NDX5-7;C9J6H0;C9JYH7 E7EX82 PHC3 Polyhomeotic-like protein 3 1 4580590.0 967890.0 1451700.0 2161000.0 True False 1325745.0892437543 1387559.0938700645 1650616.307192038 1.0 1.0466258597733678 1.2450480266410795 20.338371973856535 -6.943453977250299 0.6266086907157522 0.9978348211226047 1.3044709137424824 0.9985821869329725 0.004000566712044839 0.08622567410612658 0.04769548645142944 0.004004928173138988 0.016835333341018874 1.1390584829854237e-07 6.943453977250299 0.3066360926198777 SQK(ub)PEAGGCGAPAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQKPEAGGCGAPAAR 15 1 O60343-2;O60343-3;O60343 O60343-2 TBC1D4 TBC1 domain family member 4 1 2404510.0 645360.0 1062300.0 696850.0 True False 846073.2096751307 903808.9808129672 624746.6466572053 1.0 1.0682396871542659 0.7384073145361632 19.690422977812265 -6.852749011881983 1.221747078501721 1.0365194019082806 0.7245054764377546 0.9442116772463655 0.033576778240901446 0.1544587100330178 0.44228467413843997 0.021488897853070194 0.04982207783746429 1.403624655071304e-07 6.852749011881983 -0.312013925470526 SQK(ub)PEAGGCGAPAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQKPEAGGCGAPAAR 15 1 O60343-2;O60343-3;O60343 O60343-2 TBC1D4 TBC1 domain family member 4 1 1810360.0 605790.0 628920.0 575650.0 True False 586559.5280426804 880051.0357744737 424869.9958701713 1.0 1.5003609927046275 0.724342501583669 19.161918004606942 -6.732616780040821 1.7138050892667247 1.3002314422144792 0.7245866268494411 0.5713420460425278 0.21029914583751552 0.33133458559570406 1.9077139374765297 0.09719819601426376 0.24046879483157793 1.8509011274098507e-07 6.732616780040821 -0.5756448153650381 SQK(ub)PEAGGCGAPAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQKPEAGGCGAPAAR 15 1 O60343-2;O60343-3;O60343 O60343-2 TBC1D4 TBC1 domain family member 4 1 7301100.0 1101400.0 1523900.0 4675800.0 True False 1670904.3231256446 1251948.138714956 3751626.0805240567 1.0 0.7492638096554946 2.2452668465817065 20.6721976955994 -6.863811905770859 1.1664048472914932 0.8623352268822605 2.3231381994672144 0.9581031551999425 0.13390261182092633 0.14292195588270865 0.3673552403642262 0.08939285528240264 0.20963725325833232 1.368321321306331e-07 6.863811905770859 1.460802972584954 up SQK(ub)PEAGGCGAPAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQKPEAGGCGAPAAR 15 1 O60343-2;O60343-3;O60343 O60343-2 TBC1D4 TBC1 domain family member 4 1 2313230.0 645360.0 749720.0 918150.0 True False 883967.0321982352 716594.8914074982 701301.8798928136 1.0 0.8106579378028176 0.7933575058210341 19.753633039335156 -13.999999999832868 0.33860106254644157 3.171346865070646 0.7905937439004667 0.9997324007876075 0.0015311623493159514 19.57588848271708 0.18656740940000807 30.403240505454114 0.005371974344085912 1.0000000003848359e-14 13.999999999832868 -2.380753121170179 SQK(ub)PEAGGCGAPAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQKPEAGGCGAPAAR 15 1 O60343-2;O60343-3;O60343 O60343-2 TBC1D4 TBC1 domain family member 4 1 1542420.0 605790.0 300370.0 636260.0 True False 503741.2260473353 298751.8471912232 769299.0242661472 1.0 0.5930661056578883 1.5271710642040206 18.94232328004122 -6.7882845433819305 1.503025727718056 0.772057420698532 1.536663002451527 0.7957683291549482 0.1728134632991323 0.2379168819369121 1.0618023001200454 0.09050665443580251 0.21218008107253297 1.628228891374903e-07 6.7882845433819305 0.7646055817529951 SQK(ub)PEAGGCGAPAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQKPEAGGCGAPAAR 15 1 O60343-2;O60343-3;O60343 O60343-2 TBC1D4 TBC1 domain family member 4 1 5181700.0 1101400.0 1262500.0 2817800.0 True False 1425784.011839786 1192240.765173308 2304989.313069571 1.0 0.8362001223697821 1.6166469071954919 20.44332401769185 -6.851898084183687 1.2258662039139336 0.912427691302545 1.649013233883812 0.9430290537033429 0.08020307034895147 0.15537807444885712 0.44836259984625715 0.05116915835392438 0.11856326670640777 1.4063775197950664e-07 6.851898084183687 0.736585542581267 SQK(ub)PVMVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQKPVMVK 8 1 P46779 P46779 RPL28 60S ribosomal protein L28 1 7090330.0 833430.0 1683700.0 4573200.0 True False 1092634.8009476021 1432498.523011196 4100009.1332320087 1.0 1.3110496954415531 3.7524057715132457 20.059379848740296 -6.930452713573771 0.7430661979292713 0.9634914154793449 4.259431954313523 0.9966264949493662 0.0714842734410701 0.09240337630878749 0.07653336998170189 0.06530191558612786 0.22035313294956477 1.1736734662988658e-07 6.930452713573771 3.2959405388341776 up SQK(ub)PVMVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQKPVMVK 8 1 P46779 P46779 RPL28 60S ribosomal protein L28 1 9588100.0 1512500.0 2555600.0 5520000.0 True False 1464486.515400641 3576064.407277944 4074146.403549631 1.0 2.4418554692527414 2.781962387980789 20.48196347865331 -10.186985073556025 0.33072549804124063 4.80513688131151e-14 2.865895768967491 0.998944304057238 0.025097802747589913 1.6075263573263925 0.1522043391903243 1.569364762932718 0.10766003470991746 6.501520352992622e-11 10.186985073556025 2.865895768967443 SQK(ub)PVMVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQKPVMVK 8 1 P46779 P46779 RPL28 60S ribosomal protein L28 1 8255900.0 1512500.0 2393000.0 4350400.0 True False 1257710.7651110035 2380108.434026691 5260048.526023083 1.0 1.8924131843752061 4.182240203341855 20.262368754087586 -6.954901757519638 0.5021565591742875 0.9549867163496832 5.21879182233225 0.9995319233072614 0.02899635390074003 0.08157512573262676 0.028263319295330866 0.033868905038693886 0.18890522139911908 1.1094257519318813e-07 6.954901757519638 4.263805105982566 SQLAVPHPETQDSSTQTDTSHSGITNK(ub)LQHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQLAVPHPETQDSSTQTDTSHSGITNKLQHLK 32 1 Q96R06 Q96R06 SPAG5 Sperm-associated antigen 5 1 80209000.0 23827000.0 36028000.0 20354000.0 True False 30844521.20038732 34023010.12884269 16649780.849676374 1.0 1.103048736201989 0.5397970272097237 24.87851091569352 -6.8595015872955285 1.1881976283394238 1.0558409553254149 0.5127735667318998 0.9530333864441636 0.0530680096339476 0.14732151126580845 0.39549666547727286 0.03484058803498355 0.08128614933670002 1.3819693549557325e-07 6.8595015872955285 -0.5430673885935151 SQLDIIIHSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQLDIIIHSLK 11 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 25958000.0 7003800.0 7681200.0 11273000.0 False True 9182049.624895683 6535194.901083096 10106578.09825167 1.0 0.7117359596232135 1.1006886818438961 23.130384798520765 -6.708237661710575 1.8017032953406618 0.8224576528297155 1.0997184513493037 0.45657730446093836 0.1215076357576962 0.37865598030999864 2.394991677382642 0.0536933342101988 0.13668754392186125 1.9577730158229304e-07 6.708237661710575 0.2772607985195882 SQLDIIIHSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQLDIIIHSLK 11 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 16980400.0 6192200.0 5621500.0 5166700.0 False True 5995632.00043891 7866194.265735232 3813386.2723224475 1.0 1.3119875044297895 0.6360274066259051 22.515480405672886 -6.781229675234151 1.5312617378613869 1.1763770893763141 0.6304835340484936 0.7716339855085582 0.13200453532757098 0.24868203054182506 1.1518385276921697 0.06789478287745983 0.16002708290096151 1.6548945463730003e-07 6.781229675234151 -0.5458935553278206 SQLDIIIHSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQLDIIIHSLK 11 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 34035400.0 7647400.0 12942000.0 13446000.0 False True 11601664.899828427 10632398.983692462 10788392.206408843 1.0 0.9164545843631202 0.9299003461622469 23.467828518734393 -9.956070374022303 6.289870830595784 1.000000020859602 0.923177465265413 0.9775410064875028 0.005489209268493386 1.6028868370496407e-09 2.7071511482538804e-10 0.005314905445741903 0.0017716346733912243 1.1064444787810416e-10 9.956070374022303 -0.07682255559418905 SQLDIIIHSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQLDIIIHSLK 11 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 26563000.0 7003800.0 7770200.0 11789000.0 False True 9593294.130578276 7426886.871384707 9004681.002076328 1.0 0.7741748319497237 0.9386432730519786 23.193594860043657 -10.440114603216209 4.911227901584294 1.0002555066917693 0.8564090525008335 0.5040453832541318 0.06714395991531302 0.0001881782998091849 2.1452618169043186e-05 0.06512700249981397 0.02167061987919345 3.6298225704542365e-11 10.440114603216209 -0.14384645419093578 SQLDIIIHSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQLDIIIHSLK 11 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 16500400.0 6192200.0 3967400.0 6340800.0 False True 5149088.660972138 3946026.828732759 7666631.963453288 1.0 0.7663544150330783 1.4889298802646453 22.295885681107162 -6.819647471473011 1.373286389136005 0.8740192747444702 1.5046004051798159 0.8835959216835862 0.10271728011443788 0.19393850894147915 0.7187600888459017 0.05877710806540433 0.1354921202962919 1.514790345641598e-07 6.819647471473011 0.6305811304353457 SQLDIIIHSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQLDIIIHSLK 11 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 32048100.0 7647400.0 14458000.0 9942700.0 False True 9899710.052790593 13653399.59039657 8133230.620717159 1.0 1.379171664381005 0.8215625081286609 23.238954840826842 -6.723614033495484 1.7464366426870075 1.229789980314 0.8222573140407274 0.5294644345704992 0.15949013618976407 0.3483397237951382 2.078267543486998 0.07246045597537942 0.1811255820697608 1.8896699919386882e-07 6.723614033495484 -0.40753266627327256 SQLDIIIHSLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQLDIIIHSLKK 12 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 6450000.0 1724300.0 1800600.0 2925100.0 True False 1669563.0403341027 2519588.9700049553 2158928.5588809852 1.0 1.5091307780152767 1.2931099375851982 20.67103913787365 -10.105286016754624 4.401609851298784 0.9999589392101744 1.4011203576620557 0.8213404034736822 0.08819013894961825 13250263.90045875 15210086.422783393 4761.481668042288 0.030189831494577306 7.847186660133553e-11 10.105286016754624 0.40116141845188125 SQLDIIIHSLK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQLDIIIHSLKK 12 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 18592400.0 2647800.0 3580600.0 12364000.0 True False 4016906.180109027 2941613.954644508 9920249.980666287 1.0 0.7323083544273038 2.4696245159494943 21.937653335145665 -6.86756890753099 1.1468050598321198 0.8506006658180499 2.5668090639393544 0.9621999558646658 0.14848858585256336 0.13921114612855925 0.3436946024115657 0.10062385453949557 0.23728887377950122 1.3565352779384858e-07 6.86756890753099 1.7162083981213043 up SQLDIIIHSLK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQLDIIIHSLKK 12 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 4235000.0 1313700.0 1188500.0 1732800.0 True False 1799410.3914076174 1135988.1401560733 1323548.3281362157 1.0 0.6313113148509877 0.7355455622887945 20.779092828802295 -10.25937294478925 8.023778614594232 1.0000003612803754 0.683428438569892 0.9248050719633241 0.04255345332427194 2.7504310356539427e-07 2.5327400432758722e-08 0.041202251285291334 0.01373406800404332 5.503349004275748e-11 10.25937294478925 -0.3165719227104834 SQLDIIIHSLK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQLDIIIHSLKK 12 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 15297000.0 2647800.0 3457000.0 9192200.0 True False 3427629.2959409715 3264614.911052772 7519313.919936877 1.0 0.9524410690849088 2.1937360404876087 21.708779657238114 -6.897990914196233 0.9738911685938592 0.9455081850103179 2.3188385659295405 0.9855396970734076 0.06905661692615717 0.1128989539540183 0.18588174443528904 0.053376370507239125 0.13752652542049873 1.2647628070900333e-07 6.897990914196233 1.3733303809192225 up SQLDIIIHSLKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQLDIIIHSLKK 12 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 16060900.0 6811200.0 4198300.0 5051400.0 False True 8929549.159754625 3571930.004845224 4528729.584450313 1.0 0.4000123568325119 0.5071621762116776 23.090155906887304 -9.90509570175585 5.6749507075916865 1.000000334189568 0.4535872665217513 0.9719679738339452 0.043743730588500555 119447281.99597369 72.26270890070363 521.6570233017014 0.014974642494930584 1.244240398957999e-10 9.90509570175585 -0.5464130676678167 SQLDIIIHSLKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQLDIIIHSLKK 12 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 26604800.0 7102600.0 8412200.0 11090000.0 False True 10775163.469613409 6910977.185181411 8898056.639080329 1.0 0.6413802634800643 0.8257931922957242 23.36120642076597 -10.138815614226857 4.740098067015293 1.000019596831833 0.7335867278880982 0.735639159874425 0.07528626294968709 1.7546644270165122e-05 3.1878798136636663e-06 0.07290164014775782 0.024298536880395197 7.264143012871346e-11 10.138815614226857 -0.26643286894373486 SQLDIIIHSLKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQLDIIIHSLKK 12 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 14503600.0 6811200.0 2811500.0 4880900.0 False True 9329484.705758978 2687278.6336127953 3728131.9452908863 1.0 0.2880414855017631 0.3996074877521966 23.153365968410196 -10.143666838920074 7.52748985915615 1.000000234952858 0.34382448664053583 0.978778819647051 0.045546629692626996 1.7964585432113782e-07 2.0340800980990995e-08 0.04410035033962482 0.014700111522951715 7.183451453140557e-11 10.143666838920074 -0.6561757483123223 SQLDIIIHSLKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQLDIIIHSLKK 12 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 5946500.0 2073000.0 1742800.0 2130700.0 False True 1723791.3494711488 1733411.1904812856 2576219.518756298 1.0 1.0055806295890093 1.494507742800003 20.717153728147682 -6.90939336289436 0.8998556600385724 0.9845697310293263 1.5568803346228337 0.9906905721540218 0.022366179270348292 0.10482072282634097 0.1409534171071972 0.018256715882710283 0.050187499059712176 1.2319884522895106e-07 6.90939336289436 0.5723106035935074 SQLDIIIHSLKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQLDIIIHSLKK 12 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 33084600.0 7102600.0 13195000.0 12787000.0 False True 9194455.71317711 12460686.650662785 10459897.20569969 1.0 1.355239183196527 1.1376309302038403 23.13233274285842 -10.190957140897419 4.272952344035933 0.9999177953175811 1.2464350566570706 0.6309946349452213 0.08883819734641438 62395964.34077613 8.425601622828504 52819.61441477679 0.030411677898352592 6.442328396109178e-11 10.190957140897419 0.24651726133948948 SQLLGSAHEVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQLLGSAHEVQR 12 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 3914640.0 437140.0 1799500.0 1678000.0 False True 573094.7732697818 1531021.6143960627 1504376.6565125762 1.0 2.671498128766463 2.625005019552669 19.128414213105202 -10.280152288252053 4.91974915358319 0.9995262455228553 2.648251574160745 0.9994036071901004 0.018980732358957537 9.865588119841888e-05 1.4435133341791381e-05 0.018382756879921854 0.00612600502650681 5.246234652805515e-11 10.280152288252053 1.6487253286378896 SQLLGSAHEVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQLLGSAHEVQR 12 0 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 0 3608640.0 437140.0 1289800.0 1881700.0 False True 598762.4712643118 1232812.37120177 1437281.2148279776 1.0 2.058933935185743 2.4004196719161417 19.191624274628094 -10.24835903383824 0.2582775860270967 4.61224096933377e-12 2.570226783893146 0.9990939332613961 0.01794629005054865 1.7713354392408613 0.12227344334875105 1.3607485212185984 0.1477368946867668 5.6447013104390016e-11 10.24835903383824 2.5702267838885335 SQLLK(ub)DPQVLFAGYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQLLKDPQVLFAGYK 15 1 P52435;A0A0B4J2F8;F6S314;E2QRJ6;A6NFM0;Q9H1A7;Q9GZM3 P52435 POLR2J;POLR2J3;POLR2J2 DNA-directed RNA polymerase II subunit RPB11-a;DNA-directed RNA polymerase II subunit RPB11-b2;DNA-directed RNA polymerase II subunit RPB11-b1 1 15596400.0 1671400.0 2810000.0 11115000.0 True False 1618342.3218781045 3932047.6539564147 8203648.057147495 1.0 2.4296760955946755 5.069167348739338 20.62608537724004 -6.961579402916839 0.4125790304576696 0.8735768907103296 6.7236321217799855 0.9998243492185234 0.022338846124638254 0.07914177895851332 0.019082364565530533 0.034016433727096805 0.2201971459469355 1.0924978653881952e-07 6.961579402916839 5.850055231069656 SQLLK(ub)DPQVLFAGYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQLLKDPQVLFAGYK 15 1 P52435;A0A0B4J2F8;F6S314;E2QRJ6;A6NFM0;Q9H1A7;Q9GZM3 P52435 POLR2J;POLR2J3;POLR2J2 DNA-directed RNA polymerase II subunit RPB11-a;DNA-directed RNA polymerase II subunit RPB11-b2;DNA-directed RNA polymerase II subunit RPB11-b1 1 12452300.0 1671400.0 2733800.0 8047100.0 True False 1389843.1555745672 2719072.476783184 9729711.404413471 1.0 1.9563880038385393 7.000582306995041 20.406490652674318 -6.938621452328138 0.672265588672651 0.9418044227807588 8.307397340100263 0.9979777132724674 0.11837841789161338 0.08840119511652257 0.057515960789672735 0.11406279230025844 0.4368464849981081 1.1518039078433662e-07 6.938621452328138 7.365592917319503 SQLLQYVYNLVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQLLQYVYNLVPR 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 320257000.0 186770000.0 88845000.0 44642000.0 False True 244857278.68325266 75589672.31509748 40022874.07630186 1.0 0.3087091089208758 0.1634538874708129 27.867365841664487 -13.999999999999924 0.21927321343022807 5.158304274488381 0.0852133930726961 0.9994971747398047 0.00818387564519738 12.979951777512747 0.1483495160276352 23.362424256198466 0.08077483706448996 1.0000000000001759e-14 13.999999999999924 -5.073090881415685 SQLLQYVYNLVPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQLLQYVYNLVPR 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 2487400000.0 919400000.0 435800000.0 1132200000.0 False True 890214150.2541165 609817212.6669775 835642854.7280607 1.0 0.6850230503445737 0.9386986878264313 29.72957719219552 -9.927821903463482 6.1677118568622555 1.0000000458769076 0.8118608701496949 0.42309831115125796 0.10356264533439793 6.531980000248442e-08 1.1386306621528942e-08 0.10027412407445313 0.03342470005576118 1.1808047636657079e-10 9.927821903463482 -0.18813917572721273 SQLLQYVYNLVPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQLLQYVYNLVPR 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 390297000.0 148340000.0 90997000.0 150960000.0 False True 225042625.10664442 74757874.387194 121122689.83188137 1.0 0.33219428697904374 0.5382211026665864 27.745623045900093 -10.194286480372549 5.09493210085561 1.000044343753406 0.4352076948224505 0.9092560987940635 0.08411009529567712 4.236963012459088e-05 6.700377204407776e-06 0.08144562198084503 0.027146416527120944 6.393129764726234e-11 10.194286480372549 -0.5648366489309554 SQLLQYVYNLVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQLLQYVYNLVPR 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 405950000.0 186770000.0 37450000.0 181730000.0 False True 255823916.26946846 35795335.16941105 138809116.8468343 1.0 0.1399217699869255 0.542596325124746 27.93057590318738 -10.72983126909709 6.38968422460653 1.0123714836477056 0.34125904778221067 0.7810995320839567 0.16439119874831176 0.028568674083274327 0.0012079396433547084 0.15695412136351594 0.05305703125127375 1.8628107302135665e-11 10.72983126909709 -0.671112435865495 SQLLQYVYNLVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQLLQYVYNLVPR 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 2152530000.0 919400000.0 482580000.0 750550000.0 False True 764521836.325989 479980245.7553694 907486534.8488939 1.0 0.6278175755737444 1.186998842583674 29.509982467629797 -6.727275484509409 1.7330966025373766 0.7753484973348229 1.1865091518359265 0.5466425747560903 0.15649270204021157 0.3413579700286699 2.007380057036839 0.0715930436256642 0.17820847667407178 1.8738055264584078e-07 6.727275484509409 0.4111606545011036 SQLLQYVYNLVPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQLLQYVYNLVPR 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 290899000.0 148340000.0 78473000.0 64086000.0 False True 192029054.21855268 74105908.56668898 52423005.577889316 1.0 0.38590987633750123 0.2729951766477248 27.516749367992542 -13.999999999999998 0.2381673558801354 5.028895225104466 0.22219419282976127 0.9995219702352388 0.0069842570101923225 13.55943732639295 0.1544702029034644 25.954399501959045 0.0557748618541009 1.0000000000000041e-14 13.999999999999998 -4.806701032274705 SQLLSYIDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQLLSYIDR 9 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 19889800.0 3424900.0 6596500.0 9868400.0 False True 4490077.066778777 5612327.912955611 8847312.632377056 1.0 1.2499402191735536 1.9704144273684372 22.098308776630326 -6.952344891434045 0.532481707876622 0.9888356756386785 2.26436469256863 0.9993726693392923 0.01030418332219399 0.0825576524613928 0.0321699936272836 0.0114542272894965 0.05959901493527509 1.1159766519951629e-07 6.952344891434045 1.2755290169299516 SQLLSYIDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQLLSYIDR 9 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 11586500.0 3195900.0 1332500.0 7058100.0 False True 3094447.9038472176 1864574.1988957045 5209371.871538705 1.0 0.6025547227915989 1.6834576096957643 21.561250603179914 -6.807186358870153 1.4263942448521905 0.782661529527652 1.7011613173716924 0.8523241726313847 0.17154396221807916 0.21067156766238868 0.8453190633103204 0.0945796296209294 0.2190675073399968 1.558883431249237e-07 6.807186358870153 0.9184997878440404 SQLLSYIDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQLLSYIDR 9 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 29348100.0 4844600.0 22203000.0 2300500.0 False True 7349612.387701563 18240701.177169222 1845805.1666550299 1.0 2.481858935539541 0.25114319902689003 22.80923673477161 -6.727621560851863 1.7320100849370974 1.8941299194467396 0.25305839876889186 0.5481759311173672 0.6230621898850012 0.34070493484470155 2.0012268715991843 0.28521163646794745 0.7096179411685468 1.8723129414001433e-07 6.727621560851863 -1.6410715206778477 SQLLSYIDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQLLSYIDR 9 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 16456500.0 3424900.0 6613800.0 6417800.0 False True 4691178.084442376 6321580.447088134 4902047.818739957 1.0 1.3475464655781784 1.0449502727250752 22.161518838153217 -10.086076276465405 4.964874566097552 0.9999943076789511 1.1962483691526433 0.359311362493722 0.12353437843667349 7.784003057571083e-06 1.4328219230580932e-06 0.11961511563113443 0.03987054919694026 8.202074761361583e-11 10.086076276465405 0.19625406147369218 SQLLSYIDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQLLSYIDR 9 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 7491300.0 3195900.0 2560000.0 1735400.0 False True 2657532.4523757114 2546208.7718797876 2098264.116416988 1.0 0.9581101331814761 0.789553525316779 21.34165587861419 -6.9447384918566195 0.6139008088455453 1.0018551006379575 0.736971720331484 0.9987209650651747 0.0032528401952986036 0.08566989445463172 0.045254602464395 0.003294339518888514 0.014232903397870299 1.135694462285621e-07 6.9447384918566195 -0.2648833803064735 SQLLSYIDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQLLSYIDR 9 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 11889300.0 4844600.0 2719600.0 4325100.0 False True 6271430.201342864 2568251.8692794656 3537976.179273614 1.0 0.4095161369617956 0.5641418409657256 22.58036305686406 -10.460496188393117 9.261360470441488 1.0000051727660926 0.4868289889640113 0.9362483427921615 0.06312567932137572 6.74234832665387e-06 3.927840371950777e-07 0.06112179112443361 0.020373725394143175 3.463409242730985e-11 10.460496188393117 -0.5131761838020813 SQLNDISSFK(ub)NIYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQLNDISSFKNIYR 14 1 Q9BTE7;H0YCN4;E9PM04 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 1 24615400.0 5515500.0 5571900.0 13528000.0 True False 5340413.471532058 7796788.727074635 9984610.968699181 1.0 1.4599597519249559 1.8696325709467578 22.348520013528443 -6.972493683437654 0.18937505123529816 0.7200688531224069 2.6207078550468057 0.9999958635113962 0.0007224438809779194 0.07550151958651466 0.006036996695526337 0.014540618650613839 0.04473644697929415 1.065384358954903e-07 6.972493683437654 1.9006390019243988 SQLNDISSFK(ub)NIYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQLNDISSFKNIYR 14 1 Q9BTE7;H0YCN4;E9PM04 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 1 89837100.0 8549100.0 17434000.0 63854000.0 True False 12969609.722928492 14322766.487536294 51233228.91179759 1.0 1.1043328822929503 3.9502521668962993 23.628631731367292 -6.914659719645615 0.8634067061107886 0.9243323065167371 4.357186089510901 0.9925642703155829 0.11786306724027516 0.10141654257248078 0.12265205210362318 0.09877702192328877 0.28232800738568936 1.2171392855519593e-07 6.914659719645615 3.4328537829941643 up SQLNDISSFK(ub)NIYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQLNDISSFKNIYR 14 1 Q9BTE7;H0YCN4;E9PM04 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 1 24634600.0 5515500.0 6897100.0 12222000.0 True False 4586382.6280791685 6859943.953332836 14777563.691856869 1.0 1.4957199408820065 3.2220520811727145 22.12892528896272 -6.948059198960856 0.5797587600451319 0.9793457577357116 3.8237781202969368 0.9990400498577715 0.029508059167675862 0.08427455016849152 0.03926067794341125 0.030924807088137583 0.14420098502951062 1.1270438176349769e-07 6.948059198960856 2.844432362561225 SQLNDISSFK(ub)NIYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQLNDISSFKNIYR 14 1 Q9BTE7;H0YCN4;E9PM04 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 1 100388100.0 8549100.0 16051000.0 75788000.0 True False 11066978.477954885 15157747.740037022 61995361.65054892 1.0 1.36963741008721 5.601832674929473 23.399758053459742 -6.924081677117093 0.7938580576304971 0.9196265913855062 6.352803552752649 0.995241799137641 0.1440062876251863 0.09582951658517863 0.09360007859983545 0.1268380041946698 0.39613035992658646 1.1910179939808409e-07 6.924081677117093 5.433176961367143 up SQLQISNNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQLQISNNR 9 0 P15924 P15924 DSP Desmoplakin 0 7221700.0 2182700.0 2199500.0 2839500.0 False True 2861540.8372968654 1871343.173583847 2545695.7784073087 1.0 0.6539634693285028 0.8896241301983593 21.44836076518372 -10.076125529425706 5.182770176140581 1.0000037161940805 0.771793799762967 0.5556177637540627 0.09620806193132181 4.13121745602835e-06 7.365497803348483e-07 0.09315457241938874 0.031051018469008908 8.392173822343338e-11 10.076125529425706 -0.22820991643111344 SQLQISNNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQLQISNNR 9 0 P15924 P15924 DSP Desmoplakin 0 4971900.0 1142000.0 1209100.0 2620800.0 False True 1105747.8350991963 1691899.9353732017 1934333.8576853033 1.0 1.5300956345272174 1.7493444674135625 20.076590986966835 -11.040959934814628 0.1692663303215095 1.8540373930615062e-19 1.9860813929093692 0.9995369324798693 0.006769230529123201 3.240254527803463 0.09754937225645857 1.4298382286950755 0.17360121405266069 9.099972191871829e-12 11.040959934814628 1.9860813929093692 SQLQISNNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQLQISNNR 9 0 P15924 P15924 DSP Desmoplakin 0 6867800.0 2182700.0 1888800.0 2796300.0 False True 2989703.175249605 1805346.5705736598 2135871.5316062444 1.0 0.6038547858259992 0.7144092260690476 21.51157082670661 -10.276525345036694 8.168056592006122 1.0000004199564931 0.6591320059475251 0.926875547774537 0.0451336612324138 3.45158415149294e-07 3.0534261816363507e-08 0.043700533622521937 0.014566826525542162 5.290231229934149e-11 10.276525345036694 -0.34086841400896806 SQLSLADSTK(ub)ALGDAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQLSLADSTKALGDAFK 17 1 Q8N9Z2;A0A0C4DGU7;Q8N9Z2-2 Q8N9Z2 CCDC71L Coiled-coil domain-containing protein 71L 1 7936700.0 2735100.0 2992400.0 2209200.0 True False 3585742.5867460757 2545945.5842838404 1980613.176142783 1.0 0.710019060959473 0.5523578807535411 21.773840493070203 -13.999999999999932 0.07426240146654539 2.624199581308806 0.02715783237931887 0.9999092393092299 0.001766184068134237 12.31640754055588 0.07496463912412404 3.381528613886184 0.4806508766708034 1.0000000000001554e-14 13.999999999999932 -2.5970417489294872 SQLSLADSTK(ub)ALGDAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQLSLADSTKALGDAFK 17 1 Q8N9Z2;A0A0C4DGU7;Q8N9Z2-2 Q8N9Z2 CCDC71L Coiled-coil domain-containing protein 71L 1 20272900.0 6810700.0 7474600.0 5987600.0 True False 6594498.0564886965 10459246.759524055 4419267.935850323 1.0 1.5860565383338943 0.6701447021433204 22.65283142152678 -6.733852924921535 1.7092121913517604 1.3511435848301254 0.6702898930074876 0.5771606914377448 0.24629560846140694 0.32899134497987775 1.8845997712396256 0.11411530103427868 0.28193934451370634 1.8456403447812297e-07 6.733852924921535 -0.6808536918226378 SQLSLADSTK(ub)ALGDAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQLSLADSTKALGDAFK 17 1 Q8N9Z2;A0A0C4DGU7;Q8N9Z2-2 Q8N9Z2 CCDC71L Coiled-coil domain-containing protein 71L 1 8041200.0 2735100.0 3092000.0 2214100.0 True False 3746340.3832982993 2955385.216123335 1691175.180820866 1.0 0.788872583307926 0.45142058857234585 21.837050554593095 -6.964180519195634 0.371848706969967 1.0254124786020904 0.20310030221558337 0.9998952425449842 0.0023123825699800904 0.0782401652102777 0.015847246238914925 0.004435766393881705 0.028631431087113843 1.0859741329035783e-07 6.964180519195634 -0.822312176386507 down SQLSLADSTK(ub)ALGDAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQLSLADSTKALGDAFK 17 1 Q8N9Z2;A0A0C4DGU7;Q8N9Z2-2 Q8N9Z2 CCDC71L Coiled-coil domain-containing protein 71L 1 15087500.0 6810700.0 6304700.0 1972100.0 True False 5663398.815167946 6270735.329715031 2384456.9920398407 1.0 1.1072388744583008 0.421029327063051 22.433236696961057 -6.8669706321019985 1.150087182359603 1.0596630053171932 0.38310358674665684 0.9615604303318384 0.059092993250624434 0.13978788502672382 0.3474847906563128 0.03994693598374673 0.09410377992134655 1.3584053016790236e-07 6.8669706321019985 -0.6765594185705364 down SQMK(ub)EDPDMASAVAAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQMKEDPDMASAVAAIR 17 1 Q14232;H0YGG4;Q14232-2 Q14232 EIF2B1 Translation initiation factor eIF-2B subunit alpha 1 12296200.0 6490500.0 0.0 5805700.0 True False 9846563.019109314 0.0 4658200.850271296 1.0 0.0 0.4730788642931633 23.231188803478933 -10.507461251780297 7.160856144443543 1.0002268754425 0.236539432146584 0.7764124473777676 0.19313363760226976 0.0006997374813074927 4.81294975786386e-05 0.18705378152996255 0.06233361350217077 3.108413226331328e-11 10.507461251780297 -0.7636874432959161 SQMK(ub)EDPDMASAVAAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQMKEDPDMASAVAAIR 17 1 Q14232;H0YGG4;Q14232-2 Q14232 EIF2B1 Translation initiation factor eIF-2B subunit alpha 1 8219300.0 3087800.0 3683700.0 1447800.0 True False 2567642.512733725 3663855.176942802 1750528.2861291457 1.0 1.426933523172569 0.6817648007648028 21.292012922482364 -6.751326377739085 1.6450242420281058 1.250640205308123 0.6801401625474576 0.6546344242457303 0.17941272915068018 0.297731711339021 1.5856143317818987 0.08614296273460262 0.20883417280816216 1.7728566561682341e-07 6.751326377739085 -0.5705000427606653 SQMK(ub)EDPDMASAVAAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQMKEDPDMASAVAAIR 17 1 Q14232;H0YGG4;Q14232-2 Q14232 EIF2B1 Translation initiation factor eIF-2B subunit alpha 1 18144100.0 6490500.0 6539600.0 5114000.0 True False 8402080.196882272 6175665.511229588 4183304.474071186 1.0 0.7350162538940259 0.49788913888532854 23.002315125571382 -6.972440472456274 0.19110293527431862 1.1584137659568383 0.06800620577081588 0.9999956878557332 0.00042584680643637494 0.07551846201504245 0.006104510894331645 0.008293373466004977 0.02577098769774218 1.0655149008399821e-07 6.972440472456274 -1.0904075601860224 down SQMLAMNIEK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQMLAMNIEKK 11 1 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 12091900.0 2718400.0 5091500.0 4282000.0 True False 3563848.7250230513 4331868.046511561 3838939.7158443728 1.0 1.2155027838572305 1.0771893006820996 21.76500466928982 -10.196766955615411 3.902405087164197 0.9998933158791714 1.1463460423110565 0.598828093995436 0.056466243215630055 26454643.666256193 23172278.68604938 29605.950537236233 0.020664526992457105 6.356719447916188e-11 10.196766955615411 0.14645272643188512 SQMLAMNIEKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQMLAMNIEKK 11 1 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 29999800.0 4870700.0 6824100.0 18305000.0 True False 7389207.995867138 5606286.0380633455 14687008.7266335 1.0 0.7587127119982278 1.9876296261856616 22.816988308300754 -6.855731718463576 1.2070342790599535 0.8702911195385052 2.042487112429849 0.948240456838295 0.12095429675669471 0.15127149970424644 0.4212293662609428 0.07827800283707417 0.18194281201428295 1.394017678986415e-07 6.855731718463576 1.1721959928913437 SQNPPQSK(ub)GCCFVTFYTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQNPPQSKGCCFVTFYTR 18 1 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4;E9PQK4;E9PSH0;E9PKU1;F5H4Y5;F5H0D8;Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3;V9GYD9 G5EA30;Q5VZZ6 CELF1;CELF2 CUGBP Elav-like family member 1;CUGBP Elav-like family member 2 1 8637800.0 2115000.0 3850400.0 2672400.0 True False 2772785.4816891337 3275935.328741646 2395885.683470925 1.0 1.1814600698017221 0.8640717788277628 21.40290457500027 -6.751644780514914 1.6436816976413708 1.1064920766723487 0.8633594408164065 0.6559878981366273 0.0762582246961645 0.2972164367918764 1.5803531077117556 0.03664140012107819 0.08880499435068052 1.771557363569495e-07 6.751644780514914 -0.24313263585594225 SQNPPQSK(ub)GCCFVTFYTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQNPPQSKGCCFVTFYTR 18 1 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4;E9PQK4;E9PSH0;E9PKU1;F5H4Y5;F5H0D8;Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3;V9GYD9 G5EA30;Q5VZZ6 CELF1;CELF2 CUGBP Elav-like family member 1;CUGBP Elav-like family member 2 1 8059900.0 2115000.0 2943300.0 3001600.0 True False 2896972.6557258978 2813255.2738084733 2292683.8998924685 1.0 0.9711017700660873 0.7914068140618981 21.466114636523162 -6.935083263234072 0.7038133148339422 1.0022866381839215 0.7492375592359849 0.9974464204169359 0.004663059414324427 0.09008289257552098 0.06536975337158503 0.004385012730748833 0.01582959415812315 1.1612259614647037e-07 6.935083263234072 -0.2530490789479366 SQNTDMVQK(ub)SVSK ddPTM_RPMI8226_Bortezomib_1h_R1 2 SQNTDMVQKSVSK 13 1 Q14677;H0YDU9 Q14677 CLINT1 Clathrin interactor 1 1 88609250.0 38290500.0 34077800.0 16240950.0 True False 50199216.30572949 28993525.074223988 14560492.288193056 1.0 0.5775692771306234 0.29005417533841443 25.58116150566521 -8.212884005001833 0.2253547153442354 1.2347891159120286 5.1314976480339625e-19 0.9996603431671479 0.005373631883688313 0.08784053018823641 0.048017100275556626 0.09855058512539089 0.10868278195406393 6.125139652260676e-09 8.212884005001833 -1.2347891159120286 down SQNTDMVQK(ub)SVSK ddPTM_RPMI8226_Bortezomib_2h_R1 2 SQNTDMVQKSVSK 13 1 Q14677;H0YDU9 Q14677 CLINT1 Clathrin interactor 1 1 224760500.0 80433100.0 69780600.0 74546800.0 True False 77879795.26735304 97644357.48102178 55020756.72393724 1.0 1.253782924644564 0.7064830683626844 26.21474575567649 -6.780611784820708 1.5334419393006842 1.1435832693176455 0.7020604286684782 0.7695677670636918 0.10735011125135058 0.24962273999051207 1.1594186410922025 0.05513553209061345 0.13003278590658357 1.6572507154532805e-07 6.780611784820708 -0.44152284064916736 SQNTDMVQK(ub)SVSK ddPTM_RPMI8226_Bortezomib_8h_R1 2 SQNTDMVQKSVSK 13 1 Q14677;H0YDU9 Q14677 CLINT1 Clathrin interactor 1 1 223833500.0 47132900.0 18855600.0 157845000.0 True False 71504055.1765468 15490670.860524792 126646866.56407896 1.0 0.21664045238102392 1.77118439298837 26.091521727322085 -6.769723964925188 1.5757328153823964 0.5505249880809362 1.7797930299429183 0.7294305897565665 0.3301194891935013 0.2668722264553689 1.3077097259900967 0.16514692551016985 0.3931822093709327 1.6993233894606055e-07 6.769723964925188 1.2292680418619821 SQNTDMVQK(ub)SVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SQNTDMVQKSVSK 13 1 Q14677;H0YDU9 Q14677 CLINT1 Clathrin interactor 1 1 84839200.0 38290500.0 26521400.0 20027300.0 True False 52447532.61185466 25349596.85345841 15297264.215190703 1.0 0.483332496135932 0.2916679480119734 25.644371567188102 -13.999999999999906 0.13774341034884022 3.463558907017099 0.04789853241998428 0.9996120821120209 0.005891939397646769 11.932381632302315 0.116110714180116 7.911841527885792 0.21761320541889326 1.0000000000002168e-14 13.999999999999906 -3.415660374597115 SQNTDMVQK(ub)SVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SQNTDMVQKSVSK 13 1 Q14677;H0YDU9 Q14677 CLINT1 Clathrin interactor 1 1 217814200.0 80433100.0 101136300.0 36244800.0 True False 66883686.440495886 100591458.67791612 43823420.10297944 1.0 1.5039759922235878 0.6552183714031317 25.995151031110765 -6.745842398571155 1.6652472813881227 1.2978153041838576 0.6540528446488365 0.630899001092061 0.2117445421202526 0.3073452513959926 1.6755106437003962 0.10050513867877914 0.24507245732523722 1.795385037164151e-07 6.745842398571155 -0.6437624595350211 SQNTDMVQK(ub)SVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SQNTDMVQKSVSK 13 1 Q14677;H0YDU9 Q14677 CLINT1 Clathrin interactor 1 1 141944200.0 47132900.0 24676300.0 70135000.0 True False 61014468.178357914 23303042.212788947 57371149.64587069 1.0 0.3819264988866138 0.9402876294547541 25.862648049414535 -10.550763318207308 9.201231166816815 1.00002491907736 0.6611070641706885 0.32938645375673004 0.22794997701591307 0.00011653374157702317 5.689443122219693e-06 0.22072778589332684 0.07357053872924951 2.813433677670079e-11 10.550763318207308 -0.3389178549066715 SQNTK(ub)ISTQLDFASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQNTKISTQLDFASK 15 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 9007100.0 3141100.0 2593800.0 3272200.0 True False 3041387.499851208 3629517.8664883124 2415112.65610419 1.0 1.1933756769454327 0.7940825219484011 21.536298209599025 -6.7750011676162085 1.5551399205693497 1.1102051257398482 0.7913903119565923 0.7493698642366404 0.08162144588621711 0.2584230059127823 1.2340193520040963 0.0413522554952498 0.09799789319984449 1.6787995046041317e-07 6.7750011676162085 -0.31881481378325593 SQNTK(ub)ISTQLDFASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQNTKISTQLDFASK 15 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 7328580.0 3141100.0 3209400.0 978080.0 True False 2611963.824324081 3192110.325183981 1182592.0058690386 1.0 1.2221112311959486 0.4527597185137384 21.3167034850333 -6.829493269973902 1.3302307819771912 1.1187221306676727 0.4322788038667571 0.904847778899784 0.09972761085281155 0.18143665151036503 0.6280877253943132 0.05886767326929045 0.13546986447794285 1.4808352027898885e-07 6.829493269973902 -0.6864433268009156 down SQNVMAAASIANIVK ddPTM_RPMI8226_Bortezomib_1h_R1 2 SQNVMAAASIANIVK 15 0 P17987;E7ERF2;F5GZI8;F5GYL4 P17987 TCP1 T-complex protein 1 subunit alpha 0 114583800.0 39893600.0 48865400.0 25824800.0 False True 52300895.93017201 41574872.795837305 23152697.42497381 1.0 0.7949170287894257 0.44268261591322344 25.640332324698 -6.962910023368641 0.39227906767629606 1.0210911505625373 0.20380617191046016 0.9998633579773679 0.002690335731954357 0.07867760890323741 0.01740724122689177 0.0045424407176408565 0.029601044282013125 1.0891557199897214e-07 6.962910023368641 -0.8172849786520772 down SQNVMAAASIANIVK ddPTM_RPMI8226_Bortezomib_2h_R1 2 SQNVMAAASIANIVK 15 0 P17987;E7ERF2;F5GZI8;F5GYL4 P17987 TCP1 T-complex protein 1 subunit alpha 0 65536000.0 27265800.0 6440700.0 31829500.0 False True 26400262.103544336 9012505.09780679 23492399.085467953 1.0 0.34137937958566056 0.8898547670977104 24.654048917037937 -10.276711477026065 7.981124456095123 1.000000648796307 0.6156170733417458 0.3957215678052264 0.22391413931329915 2.5848685193137205e-06 2.3416825425176215e-07 0.21680429978108204 0.07226797771173127 5.287964403334815e-11 10.276711477026065 -0.38438357545456114 SQNVMAAASIANIVK ddPTM_RPMI8226_Bortezomib_8h_R1 2 SQNVMAAASIANIVK 15 0 P17987;E7ERF2;F5GZI8;F5GYL4 P17987 TCP1 T-complex protein 1 subunit alpha 0 192107900.0 36178900.0 106114000.0 49815000.0 False True 54886036.33187795 87177127.62753373 39969043.41530988 1.0 1.5883298094328053 0.7282187981954121 25.709935821144374 -6.722608402039115 1.7502899425694813 1.3569361131530928 0.7293908657992029 0.5246691307874094 0.24749478299816358 0.35025705531090817 2.0984642392464337 0.11222413636901023 0.28082560142843577 1.8940506909796233e-07 6.722608402039115 -0.62754524735389 SQNVMAAASIANIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SQNVMAAASIANIVK 15 0 P17987;E7ERF2;F5GZI8;F5GYL4 P17987 TCP1 T-complex protein 1 subunit alpha 0 88552500.0 39893600.0 31443000.0 17215900.0 False True 54643342.00400324 30053744.29190362 13149858.992590176 1.0 0.5499982832254631 0.24064887889958855 25.703542386220892 -8.201066085386536 0.2596269640828823 1.186777649502446 4.3173037710980173e-19 0.9994222986298598 0.007493554337964912 0.08923370313010645 0.05653436443034503 0.08843018281037188 0.10143982095684449 6.294103999353592e-09 8.201066085386536 -1.186777649502446 down SQNWEMAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQNWEMAIK 9 0 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 0 3384510.0 1003100.0 888810.0 1492600.0 False True 1315073.8140342173 756203.0125542441 1338160.070030197 1.0 0.5750270475194545 1.0175551028007763 20.326712348425346 -10.973367424572656 12.299827790887566 1.095815101770627 0.7962910751601154 0.22029615094055754 0.1806613220508975 0.08392174664317598 0.00018171394879049863 0.030926122202753606 0.05830819096724503 1.0632431059257633e-11 10.973367424572656 -0.2995240266105116 SQPFVDHVFTFTILDNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQPFVDHVFTFTILDNR 17 0 Q8TDN6 Q8TDN6 BRIX1 Ribosome biogenesis protein BRX1 homolog 0 2823280.0 1228000.0 782730.0 812550.0 False True 1609919.8919689173 665949.7350576438 728475.1205299738 1.0 0.413653957802331 0.45249153337626963 20.61855747236314 -9.946223737688383 5.917848170189933 1.0000003291845292 0.43307274792701933 0.9964926027958845 0.0158553738345247 6.88729757986912e-08 1.2254009098559162e-08 0.015351908852072719 0.0051172999006478224 1.1318171290504297e-10 9.946223737688383 -0.5669275812575099 SQPFVDHVFTFTILDNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQPFVDHVFTFTILDNR 17 0 Q8TDN6 Q8TDN6 BRIX1 Ribosome biogenesis protein BRX1 homolog 0 13486800.0 7400000.0 2262600.0 3824200.0 False True 7165091.050555208 3166067.9793031234 2822527.296459148 1.0 0.44187407486717023 0.3939276244424607 22.772553607007666 -13.999999999999998 0.347596429413538 7.762819657299572 0.38709113391890543 0.9997501030427088 0.004348835075139105 20.422965512479063 0.189621302911982 101.86406348392293 0.014424026748241746 1.0000000000000041e-14 13.999999999999998 -7.375728523380666 SQPFVDHVFTFTILDNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQPFVDHVFTFTILDNR 17 0 Q8TDN6 Q8TDN6 BRIX1 Ribosome biogenesis protein BRX1 homolog 0 55954000.0 15174000.0 18644000.0 22136000.0 False True 23020067.367993902 15316832.533763131 17760809.897446543 1.0 0.6653687102175464 0.7715359652743848 24.456388719720277 -10.635610934950506 9.55915138841342 1.000092534075126 0.7184523377459657 0.9036325306094128 0.04334260038019521 8.550255596133637e-05 3.259288243205886e-06 0.0419799112988963 0.013988764121151614 2.3141369939229628e-11 10.635610934950506 -0.2816401963291604 SQPFVDHVFTFTILDNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQPFVDHVFTFTILDNR 17 0 Q8TDN6 Q8TDN6 BRIX1 Ribosome biogenesis protein BRX1 homolog 0 3970100.0 1228000.0 1095600.0 1646500.0 False True 1682024.7854522015 1047192.7693352913 1257630.610731925 1.0 0.622578679215931 0.7476885130404419 20.68176753388603 -10.913104903596853 11.074109306642676 1.0343431817531765 0.6851335961281865 0.8941257999559893 0.05107587577907456 0.02719817948579308 0.0002134153155778853 0.03105804335863872 0.01648466802377622 1.2215045707595669e-11 10.913104903596853 -0.34920958562499005 SQPFVDHVFTFTILDNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQPFVDHVFTFTILDNR 17 0 Q8TDN6 Q8TDN6 BRIX1 Ribosome biogenesis protein BRX1 homolog 0 43244000.0 15174000.0 16160000.0 11910000.0 False True 19643042.124257192 15260681.794218311 9742502.206919782 1.0 0.7769001205456305 0.4959772597997316 24.227515041812726 -6.968002001101895 0.3021217422344834 1.0475090987881195 0.2165391228277861 0.9999623351616045 0.0012655771016743791 0.07695646597190292 0.01133830058325601 0.004612247757078227 0.0251386574778448 1.0764602536045394e-07 6.968002001101895 -0.8309699759603334 down SQPLQNVSTVLQK(ub)PNPLYNQNTDMVQK ddPTM_RPMI8226_Bortezomib_1h_R1 2 SQPLQNVSTVLQKPNPLYNQNTDMVQK 27 1 Q14677-3;Q14677-2 Q14677-3 CLINT1 Clathrin interactor 1 1 159355500.0 54531500.0 69781000.0 35043000.0 True False 71491324.58379725 59369946.804207645 31417086.516192045 1.0 0.830449668541506 0.4394531322379834 26.091264846811587 -6.957167907721311 0.4736653811972156 1.0099678832051509 0.24380672308543663 0.9996503032520047 0.004389289681294009 0.08072878664927913 0.024990562989331635 0.0054441016474284865 0.032263414313986535 1.1036518415271734e-07 6.957167907721311 -0.7661611601197142 down SQPLQNVSTVLQK(ub)PNPLYNQNTDMVQK ddPTM_RPMI8226_Bortezomib_2h_R1 2 SQPLQNVSTVLQKPNPLYNQNTDMVQK 27 1 Q14677-3;Q14677-2 Q14677-3 CLINT1 Clathrin interactor 1 1 566449000.0 245327000.0 143983000.0 177139000.0 True False 237539228.67021042 201476162.76142585 130740981.84390908 1.0 0.8481805884835425 0.5503974336189515 27.823590547635092 -6.9604240464651035 0.42941760416617936 1.0119017283022123 0.37526780405051446 0.9997855991093508 0.0027344090899546983 0.07955001275306768 0.020574342750560304 0.00388087200196974 0.024728570349320123 1.0954081139678426e-07 6.9604240464651035 -0.6366339242516978 SQPLQNVSTVLQK(ub)PNPLYNQNTDMVQK ddPTM_RPMI8226_Bortezomib_8h_R1 2 SQPLQNVSTVLQKPNPLYNQNTDMVQK 27 1 Q14677-3;Q14677-2 Q14677-3 CLINT1 Clathrin interactor 1 1 648636000.0 178165000.0 86974000.0 383497000.0 True False 270289330.60621065 71452810.16903642 307698649.85729355 1.0 0.2643567543298159 1.1384047204792749 28.009929323190114 -6.683488764211621 1.889138002792073 0.5360339951993165 1.1352059215569157 0.3403680909328921 0.31154485375322966 0.43079111634945094 2.9752858375378626 0.1321737749161458 0.34709424158555197 2.0725796793415516e-07 6.683488764211621 0.5991719263575992 SQPLQNVSTVLQK(ub)PNPLYNQNTDMVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SQPLQNVSTVLQKPNPLYNQNTDMVQK 27 1 Q14677-3;Q14677-2 Q14677-3 CLINT1 Clathrin interactor 1 1 178450200.0 54531500.0 78195600.0 45723100.0 True False 74693269.20837681 74740659.83373019 34924245.47680342 1.0 1.000634469823796 0.4675688431761223 26.15447490833448 -6.906627922432568 0.9183970887905376 1.0183160172051113 0.40342680459990443 0.9895854901280673 0.025629228230227372 0.10669020092942375 0.1511773708670984 0.020639244383384568 0.0557261918130919 1.2398583682108668e-07 6.906627922432568 -0.6148892126052069 down SQPLQNVSTVLQK(ub)PNPLYNQNTDMVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SQPLQNVSTVLQKPNPLYNQNTDMVQK 27 1 Q14677-3;Q14677-2 Q14677-3 CLINT1 Clathrin interactor 1 1 488592000.0 245327000.0 148822000.0 94443000.0 True False 204000270.32885116 148020266.34714577 114190594.64490587 1.0 0.7255885794098955 0.559757075129504 27.60399582306937 -10.253137535651192 0.0858770900261961 1.8624522984993424 5.822563161790064e-15 0.999954356741803 0.0012264764380275457 2.000922454179574 0.043464478407768875 0.6698413718846579 0.3078915596259405 5.5829336218640135e-11 10.253137535651192 -1.8624522984993366 SQPLQNVSTVLQK(ub)PNPLYNQNTDMVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SQPLQNVSTVLQKPNPLYNQNTDMVQK 27 1 Q14677-3;Q14677-2 Q14677-3 CLINT1 Clathrin interactor 1 1 552504000.0 178165000.0 102080000.0 272259000.0 True False 230638104.6571958 96399158.26446831 222710655.6132474 1.0 0.4179671802616884 0.9656281902952194 27.781055645282564 -10.715942339507526 9.936276349558153 1.0004638317594075 0.6917976852784544 0.2968970116261155 0.22358167109990157 0.0023005234180009907 6.576726374745927e-05 0.21678341232917162 0.0721606740572619 1.9233470712693233e-11 10.715942339507526 -0.30866614648095303 SQPLQNVSTVLQK(ub)PNPLYNQNTDMVQK(ub)SVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQPLQNVSTVLQKPNPLYNQNTDMVQKSVSK 31 2 Q14677-3;Q14677-2 Q14677-3 CLINT1 Clathrin interactor 1 2 23688500.0 7025200.0 11395000.0 5268300.0 True False 9210105.232133586 9694910.417362114 4723186.853102029 1.0 1.0526383980431697 0.5128265892796829 23.134786209572376 -6.882946289860882 1.0631815037426473 1.0340957892878002 0.47233370650787754 0.9759873375743213 0.037657613046116506 0.12505444557337606 0.2567605001875058 0.027207250136091758 0.06631818993909953 1.3093438423753402e-07 6.882946289860882 -0.5617620827799227 SQPLQNVSTVLQK(ub)PNPLYNQNTDMVQK(ub)SVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQPLQNVSTVLQKPNPLYNQNTDMVQKSVSK 31 2 Q14677-3;Q14677-2 Q14677-3 CLINT1 Clathrin interactor 1 2 78388000.0 32367000.0 23874000.0 22147000.0 True False 31339527.30180009 33407012.701265287 16346036.304241642 1.0 1.0659705355334586 0.5215789040730922 24.90148008382765 -6.876610015788912 1.098575333175158 1.0393086287890296 0.4854275718873467 0.9708445579047266 0.041420276916950244 0.13067315511466288 0.2908178677176631 0.029127917281901974 0.0698681807595258 1.3285869558960957e-07 6.876610015788912 -0.553881056901683 SQPLQNVSTVLQK(ub)PNPLYNQNTDMVQK(ub)SVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQPLQNVSTVLQKPNPLYNQNTDMVQKSVSK 31 2 Q14677-3;Q14677-2 Q14677-3 CLINT1 Clathrin interactor 1 2 91240000.0 29079000.0 11893000.0 50268000.0 True False 44114968.959661 9770601.22956687 40332507.76675292 1.0 0.22148040585727644 0.9142590081755065 25.39476493404356 -10.841609239218036 10.070986691226643 1.0109764895488342 0.5678697070168468 0.3415747231791062 0.2828256800663619 0.06712660260512993 0.0010557269990151585 0.26371978690651654 0.09128159573140054 1.440093734172139e-11 10.841609239218036 -0.44310678253198743 SQPLQNVSTVLQK(ub)PNPLYNQNTDMVQK(ub)SVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQPLQNVSTVLQKPNPLYNQNTDMVQKSVSK 31 2 Q14677-3;Q14677-2 Q14677-3 CLINT1 Clathrin interactor 1 2 51461000.0 7025200.0 36444000.0 7991800.0 True False 9622606.28889154 34833783.57580812 6104301.436287513 1.0 3.6199946802375864 0.6343709025416946 23.197996271095267 -6.674918229657363 1.9200359680216843 2.6651983504597183 0.646162725427534 0.30101397405320107 1.1116689110878748 0.44989568657231904 3.2020768560972295 0.46535841272945405 1.2353582081564516 2.1138870117215925e-07 6.674918229657363 -2.0190356250321844 SQPLQNVSTVLQK(ub)PNPLYNQNTDMVQK(ub)SVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SQPLQNVSTVLQKPNPLYNQNTDMVQKSVSK 31 2 Q14677-3;Q14677-2 Q14677-3 CLINT1 Clathrin interactor 1 2 90422100.0 41227200.0 32340700.0 16854200.0 True False 34282243.47463433 32166474.22997367 20378335.294984005 1.0 0.9382838160452909 0.5944282879287663 25.03095818859257 -6.937422985592351 0.6831203216000937 1.0040855881317579 0.508333798174805 0.9978064481912208 0.0083568116632843 0.08896235289317865 0.06011318006614124 0.007983852082039401 0.029946477690802713 1.1549867829086273e-07 6.937422985592351 -0.4957517899569529 SQPLQNVSTVLQKPNPLYNQNTDMVQK(ub)SVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQPLQNVSTVLQKPNPLYNQNTDMVQKSVSK 31 2 Q14677-3;Q14677-2 Q14677-3 CLINT1 Clathrin interactor 1 1 60200000.0 15950000.0 28194000.0 16056000.0 True False 20910604.460019723 23987565.099351246 14394679.140027378 1.0 1.1471483354397791 0.6883913455275507 24.317731430532554 -6.820393757205527 1.3701920148561355 1.0792796061035526 0.6782927776114965 0.885287460530722 0.06477703581151954 0.19296614316663177 0.7117561138811254 0.03714995652430232 0.0856148615822047 1.5121895857037743e-07 6.820393757205527 -0.400986828492056 SQPLQNVSTVLQKPNPLYNQNTDMVQK(ub)SVSK ddPTM_RPMI8226_Bortezomib_2h_R1 2 SQPLQNVSTVLQKPNPLYNQNTDMVQKSVSK 31 2 Q14677-3;Q14677-2 Q14677-3 CLINT1 Clathrin interactor 1 1 202209200.0 89887700.0 57106500.0 55215000.0 True False 87034264.16553947 79909423.2564634 40752535.085505985 1.0 0.9181375177076857 0.4682355331688049 26.375080145746917 -6.937719926016989 0.6804436037335931 1.0053044467911376 0.35463806733863845 0.9978497630997133 0.010840626545017535 0.088822371120451 0.059462778423644315 0.010378442217014321 0.03912704797272377 1.1541973530174482e-07 6.937719926016989 -0.6506663794524992 down SQPLQNVSTVLQKPNPLYNQNTDMVQK(ub)SVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQPLQNVSTVLQKPNPLYNQNTDMVQKSVSK 31 2 Q14677-3;Q14677-2 Q14677-3 CLINT1 Clathrin interactor 1 1 165796000.0 45975000.0 23223000.0 96598000.0 True False 69747436.22271788 19078674.207872808 77505362.9595926 1.0 0.2735394337212724 1.1112288444854383 26.055636851522546 -6.6774199266126955 1.9113206430044438 0.5392832306023677 1.107955855754735 0.31218118651704496 0.30806946587573153 0.44431488257056345 3.135986419111934 0.12944841712636249 0.34251080131881184 2.101745244260613e-07 6.6774199266126955 0.5686726251523674 SQPLQNVSTVLQKPNPLYNQNTDMVQK(ub)SVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQPLQNVSTVLQKPNPLYNQNTDMVQKSVSK 31 2 Q14677-3;Q14677-2 Q14677-3 CLINT1 Clathrin interactor 1 1 71555000.0 15950000.0 21528000.0 34077000.0 True False 21847146.032542836 20576821.77642403 26028714.437844977 1.0 0.9418539952895189 1.1914011285077422 24.380941492055445 -6.845328898577983 1.2573317358519205 0.9690529534723268 1.2005179916457687 0.9332386506733772 0.02754583956585953 0.1626729644518132 0.49721871516902566 0.01716128943672243 0.039613532878007236 1.427812242530952e-07 6.845328898577983 0.23146503817344188 SQPLQNVSTVLQKPNPLYNQNTDMVQK(ub)SVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQPLQNVSTVLQKPNPLYNQNTDMVQKSVSK 31 2 Q14677-3;Q14677-2 Q14677-3 CLINT1 Clathrin interactor 1 1 169369000.0 67822000.0 76097000.0 25450000.0 True False 56396998.02403867 75687050.3569282 30771477.33249532 1.0 1.3420404101060013 0.5456226113201855 25.749115035149494 -6.7900079466090215 1.496425481915894 1.1911632773576375 0.5371648198468627 0.8013172151240917 0.14540549192516128 0.23533726477393477 1.04110349483547 0.07648503567502282 0.17905958732956648 1.6217804221653024e-07 6.7900079466090215 -0.6539984575107748 SQPLQNVSTVLQKPNPLYNQNTDMVQK(ub)SVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SQPLQNVSTVLQKPNPLYNQNTDMVQKSVSK 31 2 Q14677-3;Q14677-2 Q14677-3 CLINT1 Clathrin interactor 1 1 174986700.0 66519800.0 32477900.0 75989000.0 True False 86111192.4012895 30670476.31463139 62159781.71298309 1.0 0.356172937098617 0.7218548481283399 26.35969742996854 -10.710742589281448 6.965301001546861 1.0044557714328637 0.5390138926136497 0.6793726306093877 0.14928901503144282 0.010376628917516114 0.00043092350331933266 0.14520355766760726 0.048182822415707226 1.9465134579338364e-11 10.710742589281448 -0.46544187881921395 SQPVYIQYSNHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQPVYIQYSNHR 12 0 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;X6R242 O95758-1 PTBP3 Polypyrimidine tract-binding protein 3 0 16771160.0 7110560.0 3189900.0 6470700.0 False True 9322013.018760988 2713979.35413281 5801174.0353372665 1.0 0.2911366191691429 0.6223091540059139 23.152210097014247 -10.571336213815512 6.472990024373647 1.0009126095269196 0.45672288658852245 0.7820481491948373 0.13520062119569587 0.0017832767258233486 0.00011809461709078586 0.13110299833860106 0.04363581285731896 2.6832663614224533e-11 10.571336213815512 -0.5441897229383972 SQPVYIQYSNHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQPVYIQYSNHR 12 0 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;X6R242 O95758-1 PTBP3 Polypyrimidine tract-binding protein 3 0 10941200.0 3296700.0 1228900.0 6415600.0 False True 3192048.0630223462 1719606.178628839 4735161.89612555 1.0 0.5387156285487299 1.4834243728905911 21.6060509438675 -6.773934468569395 1.5593583151592136 0.7367476262834016 1.489549566397754 0.745371176477893 0.19463271601439497 0.2601267225804261 1.2488031536073296 0.09835096435426041 0.23328485178537506 1.682927981768847e-07 6.773934468569395 0.7528019401143524 SQPVYIQYSNHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQPVYIQYSNHR 12 0 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;X6R242 O95758-1 PTBP3 Polypyrimidine tract-binding protein 3 0 9174900.0 3296700.0 3648300.0 2229900.0 False True 2741352.11857286 3628645.8837691527 2696161.7801073217 1.0 1.3236701185465423 0.9835153105070412 21.386456219301778 -6.657464367264861 1.9825462048292377 1.2087803784692688 0.9849564497924901 0.22470540960642815 0.13789611640696806 0.49042076321709605 3.7030074864031435 0.05625651792906417 0.15276297319747223 2.20057225347309e-07 6.657464367264861 -0.2238239286767787 SQPVYIQYSNHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQPVYIQYSNHR 12 0 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;O95758-2;X6R242 O95758-1 PTBP3 Polypyrimidine tract-binding protein 3 0 6539600.0 0.0 3447900.0 3091700.0 False True 0.0 3256021.3340523127 2529042.3235209025 0.0 SQQIIGQLSSLHNIYLIASIDHLNAPLMWDHAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQQIIGQLSSLHNIYLIASIDHLNAPLMWDHAK 33 0 Q13416 Q13416 ORC2 Origin recognition complex subunit 2 0 74539000.0 17742000.0 21036000.0 35761000.0 False True 26915911.11394147 17281961.44498181 28692822.675396893 1.0 0.642072318184703 1.0660171433147232 24.681955926177363 -6.682840922264745 1.8913380262740975 0.7741267144838425 1.0644609059727395 0.3374403835505434 0.15160288608472433 0.4322056862289913 2.9914411194678046 0.0642545278868636 0.1688809499592087 2.075673676783393e-07 6.682840922264745 0.29033419148889694 SQQIIGQLSSLHNIYLIASIDHLNAPLMWDHAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQQIIGQLSSLHNIYLIASIDHLNAPLMWDHAK 33 0 Q13416 Q13416 ORC2 Origin recognition complex subunit 2 0 50706000.0 17742000.0 14037000.0 18927000.0 False True 22967368.747104995 13255828.61048531 15482480.207419906 1.0 0.5771592190836483 0.674107703755636 24.453082248269812 -10.003428604609619 5.904399578290152 1.0000004888113494 0.6256334614195868 0.9521108855846292 0.03957905313062758 2.546570111420314e-07 4.303844392426709e-08 0.03832230365865434 0.012774084469431804 9.921364270710809e-11 10.003428604609619 -0.37436702739176264 SQQK(ub)VVITK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQQKVVITK 9 1 P04839;A6NGA6;Q9Y5S8-3;Q9Y5S8 P04839 CYBB;NOX1 Cytochrome b-245 heavy chain;NADPH oxidase 1 1 5510370.0 311570.0 2321600.0 2877200.0 True False 472674.4688181014 1907292.3412564066 2308520.1588784396 1.0 4.035107599582213 4.883953568828834 18.850487415071033 -9.460686164892433 0.38728134976920536 8.063646124381307e-20 5.021821045514525 0.9982752256621679 0.06924157712520355 0.8119550692138757 0.15783405677687098 1.3572012049522912 0.22170647205684707 3.461894550505801e-10 9.460686164892433 5.021821045514525 SQQK(ub)VVITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQQKVVITK 9 1 P04839;A6NGA6;Q9Y5S8-3;Q9Y5S8 P04839 CYBB;NOX1 Cytochrome b-245 heavy chain;NADPH oxidase 1 1 2174910.0 311570.0 839240.0 1024100.0 True False 403333.5069628854 792535.5562487497 837724.3081533636 1.0 1.9649633431563092 2.0770015227880654 18.621613737163482 -10.911114095080636 0.3990311536137588 2.17011039386916e-15 2.0861374770671155 0.9994856880718086 0.010964216420415339 2.637164672789054 0.19478132919659602 2.489241407998039 0.028666369862782957 1.227116808494375e-11 10.911114095080636 2.0861374770671133 SQQLSNDHICYFLYQILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQQLSNDHICYFLYQILR 18 0 E9PQW4;P27361-3;P27361;E9PBK7;E9PJF0;B3KR49;P27361-2;H0YDH9 E9PQW4 MAPK3 Mitogen-activated protein kinase;Mitogen-activated protein kinase 3 0 96666000.0 39750000.0 27214000.0 29702000.0 False True 60303656.11425848 22357449.076047532 23831386.681150943 1.0 0.37074782055811756 0.39518974829647413 25.845742137282326 -10.294704759553436 5.647923147097959 1.0000640993789112 0.3829687844273113 0.998824541626757 0.009978375214852947 8.054694655425219e-06 1.0058430818697894e-06 0.009662517011946986 0.003220506752440509 5.073354859768135e-11 10.294704759553436 -0.6170953149515999 SQQLSNDHICYFLYQILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQQLSNDHICYFLYQILR 18 0 E9PQW4;P27361-3;P27361;E9PBK7;E9PJF0;B3KR49;P27361-2;H0YDH9 E9PQW4 MAPK3 Mitogen-activated protein kinase;Mitogen-activated protein kinase 3 0 74935000.0 39750000.0 15977000.0 19208000.0 False True 51457158.58964176 15087865.905088263 15712341.090723373 1.0 0.2932121850219189 0.30534801223723695 25.616868459374775 -9.998414536399753 5.343559746639835 1.000002966826306 0.29928009862832744 0.9997750872738593 0.004954430720756372 3033965.938649176 5676899.836201984 75.51797106816502 0.0016960331362694 1.0036573366446976e-10 9.998414536399753 -0.7007228681979785 SQQSAGK(ub)EYVGIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQQSAGKEYVGIVR 14 1 O60832;O60832-2;C9IYT0;H7C0M1 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 10631700.0 2770100.0 3166600.0 4695000.0 True False 3631627.9256865615 2694155.623310123 4209206.437620111 1.0 0.7418589344614073 1.1590412134041397 21.79218496984287 -6.739305447215686 1.6890578416237418 0.8462877681329372 1.1592587237064649 0.6019303948167098 0.10846164573600446 0.3190579187327162 1.7869730017108352 0.05080367000304877 0.12477155802193277 1.822613374262394e-07 6.739305447215686 0.3129709555735277 SQQSAGK(ub)EYVGIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQQSAGKEYVGIVR 14 1 O60832;O60832-2;C9IYT0;H7C0M1 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 13023400.0 2867600.0 2839600.0 7316200.0 True False 2776569.6076448797 3973467.088318381 5399867.738704679 1.0 1.4310705834199215 1.9447982589152204 21.404872133575548 -6.9687978914905475 0.2854402976134138 0.8939861744623836 2.497654576155578 0.9999714291733357 0.0020643173614690144 0.0766947127011426 0.010419562475920732 0.009201520695026246 0.04683853764505539 1.0744893333017099e-07 6.9687978914905475 1.6036684016931946 SQQSAGK(ub)EYVGIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQQSAGKEYVGIVR 14 1 O60832;O60832-2;C9IYT0;H7C0M1 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 11816000.0 2770100.0 2889000.0 6156900.0 True False 3794280.829137739 2761354.427354562 4702767.025335797 1.0 0.7277675405966426 1.239435676247642 21.855395031365763 -6.762156412593834 1.6042225023309045 0.842295533778091 1.2415148903058495 0.6997394927278985 0.11454048948799372 0.27931934600382147 1.4172007678158174 0.05632019334928264 0.13506676001693516 1.7291934723070917e-07 6.762156412593834 0.39921935652775853 SQQSAGK(ub)EYVGIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQQSAGKEYVGIVR 14 1 O60832;O60832-2;C9IYT0;H7C0M1 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 13756000.0 2867600.0 4690500.0 6197900.0 True False 2384536.456219713 4665231.3455086425 7493852.234148241 1.0 1.9564520950560733 3.1426872147840843 21.185277409009824 -6.9682242702418495 0.29755792209528853 0.788204226547916 4.347976321459324 0.9999650303934541 0.005182736177768094 0.07688318595858591 0.011081473522015259 0.01992236698065026 0.10666675579780382 1.075909469083185e-07 6.9682242702418495 3.5597720949114082 SQQSAGK(ub)EYVGIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQQSAGKEYVGIVR 14 1 O60832;O60832-2;C9IYT0;H7C0M1 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 30468000.0 10282000.0 4850000.0 15336000.0 True False 13310251.688520662 4580093.236507357 12545005.360648345 1.0 0.3441026769206346 0.9425069979306027 23.66603451617866 -10.671384477355708 9.620471023616512 1.0002459580867207 0.6433048374256287 0.3214561065186283 0.24429754105850815 0.0012896298775106187 4.405103172303908e-05 0.23669615334073169 0.07884669233658538 2.131157381547962e-11 10.671384477355708 -0.35694112066109196 SQRPEESEPLEK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQRPEESEPLEKK 13 2 Q5TFE4;Q5TFE4-2 Q5TFE4 NT5DC1 5-nucleotidase domain-containing protein 1 1 4918430.0 929280.0 620350.0 3368800.0 True False 1202971.2788473533 585826.9771685239 2755712.966807002 1.0 0.4869833448807221 2.2907554114238153 20.19817076764936 -6.830704048145271 1.3247454784417119 0.726011291156534 2.3400016480740686 0.9072818527670106 0.23107053487597554 0.17994116086886713 0.6173480727546143 0.13694251990271752 0.3151405982889929 1.4767125026033926e-07 6.830704048145271 1.6139903569175347 up SQSAAVTPSSTTSSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQSAAVTPSSTTSSTR 16 0 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 0 10178460.0 658360.0 5057500.0 4462600.0 False True 863116.3355673089 4302940.713980589 4000852.960281903 1.0 4.985354275738916 4.635357709516902 19.71919550132024 -10.273528654082929 4.58233899489819 0.998215105608186 4.8103559926432995 0.9937119175936181 0.14288549989118476 0.0026082538254647795 0.0004135044851804025 0.1383627546378889 0.04611609678220335 5.3268607735421575e-11 10.273528654082929 3.8121408870351132 SQSAAVTPSSTTSSTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQSAAVTPSSTTSSTR 16 0 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 0 7586400.0 2827400.0 1129600.0 3629400.0 False True 2737645.734640514 1580655.1707861794 2678751.260333884 1.0 0.5773775440647869 0.9784871820479126 21.384504335881587 -10.622730896687283 9.471850172910525 1.0000592992015254 0.7779323644064718 0.29011542636209264 0.16375232399519005 0.00020511074817240046 8.169746242462505e-06 0.15859457948095856 0.05285083531134437 2.3837960912115428e-11 10.622730896687283 -0.22212693479505352 SQSAAVTPSSTTSSTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQSAAVTPSSTTSSTR 16 0 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 0 24373300.0 1689700.0 20869000.0 1814600.0 False True 2563398.4336166717 17144763.899758782 1455943.5146325673 1.0 6.688294599435101 0.5679739425362729 21.289626306060597 -6.662624102028434 1.9636435943171255 4.653585335383305 0.593400853274273 0.24677610397747485 2.4204436754929377 0.4782637555914416 3.5478060598452683 0.9949294771798886 2.683913561009757 2.1745825463461835e-07 6.662624102028434 -4.060184482109031 SQSAAVTPSSTTSSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQSAAVTPSSTTSSTR 16 0 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 0 7943260.0 658360.0 4048400.0 3236500.0 False True 901773.4835100247 3869528.30173147 2472105.3578098225 1.0 4.291020275590587 2.741381736117927 19.78240556284313 -10.233670432813923 15.323491675101758 0.9999999999952328 3.5162010058542568 0.7785332299299964 0.632637284576631 0.0 0.0 0.6125484122749523 0.20418280561293115 5.838880234123411e-11 10.233670432813923 2.516201005859024 SQSAAVTPSSTTSSTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQSAAVTPSSTTSSTR 16 0 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 0 4501240.0 2827400.0 1255200.0 418640.0 False True 2351108.375057756 1248437.9884623066 506175.6884273414 1.0 0.5309997623702217 0.21529236754767078 21.164909611315863 -8.258276410561368 0.27442770186482973 1.1758914375039362 7.47325682591838e-12 0.9992467476776717 0.008848042817769686 0.09543889603690153 0.06318863591919643 0.09218726907389925 0.10006500926751156 5.5172617650918745e-09 8.258276410561368 -1.1758914374964629 down SQSAAVTPSSTTSSTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQSAAVTPSSTTSSTR 16 0 Q16186;A0A087WX59 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 0 5037700.0 1689700.0 1899500.0 1448500.0 False True 2187349.9589664857 1793791.1552053026 1184887.8628650967 1.0 0.8200750629098519 0.5417001783404387 21.060752628153047 -6.9647375303594545 0.3625289982549104 1.0233050969202067 0.3288929532843926 0.9999076311064575 0.0018119634823969975 0.07805014081151027 0.015174702892424324 0.0037163212966351633 0.023741250073976646 1.0845821926537229e-07 6.9647375303594545 -0.694412143635814 SQSLLTFSTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQSLLTFSTK 10 0 Q8IWA0 Q8IWA0 WDR75 WD repeat-containing protein 75 0 9456000.0 2694600.0 3010600.0 3750800.0 False True 3532646.694543519 2561430.2152268854 3362703.1962141683 1.0 0.7250739846651627 0.9518934348595224 21.752318039606326 -10.011364767523212 6.241114405306322 1.0000001091517978 0.8384837101281712 0.4033768171406752 0.09259865278581911 1.4065602434496147e-07 2.2262924434274108e-08 0.08965832148654429 0.02988608667672399 9.741710796708857e-11 10.011364767523212 -0.16151639902362658 SQSLLTFSTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQSLLTFSTK 10 0 Q8IWA0 Q8IWA0 WDR75 WD repeat-containing protein 75 0 7151300.0 2694600.0 2217100.0 2239600.0 False True 3690866.4388269535 2119141.1910307384 1710652.6060098521 1.0 0.5741581891823354 0.4634826630447074 21.815528101129217 -13.999999999999998 0.18917441393173592 3.27629548388473 0.383420028070825 0.9994898824522884 0.005223784181551917 12.33737920383415 0.13792765926952394 10.349108875835338 0.07661559709115742 1.0000000000000041e-14 13.999999999999998 -2.892875455813905 SQSSDTEQQSPTSGGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588-2;P23588 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 10518330.0 678630.0 4879500.0 4960200.0 False True 889690.5018622676 4151497.6201420273 4446966.085598149 1.0 4.666226751271666 4.9983292800023404 19.76294402502842 -9.954844945553825 0.5711057968609307 2.084882884545764e-22 4.968705344787091 0.9994109802295618 0.04396785781183442 1.2270687291197238 0.26693367663348744 2.2749585084139876 0.05981130543800267 1.1095708902728558e-10 9.954844945553825 4.968705344787091 SQSSDTEQQSPTSGGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588-2;P23588 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 11021200.0 3674100.0 2268500.0 5078600.0 False True 3557467.70660066 3174323.8800712223 3748362.305265795 1.0 0.8922987197273673 1.053660247796752 21.762419229873952 -6.726813081368608 1.7349033828899205 0.9349569517655768 1.0535089049115147 0.5444181032605995 0.045287474041340675 0.34223912313081584 2.0165624279674668 0.0206991628047411 0.05154889231196285 1.8758016719930493e-07 6.726813081368608 0.11855195314593792 SQSSDTEQQSPTSGGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQSSDTEQQSPTSGGGK 17 0 E7EX17;P23588-2;P23588 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 15172930.0 678630.0 7421900.0 7072400.0 False True 929537.8502861774 7093975.917058779 5402044.780650146 1.0 7.631723565505969 5.811538259563089 19.826154086551313 -10.070528419001512 6.05806034746909 0.9999866117162003 6.7216309125347165 0.9294527468735128 0.7430875394792926 0.00013437234239096826 2.0614153236950868e-05 0.7194930631284217 0.23983047209803088 8.501030630293101e-11 10.070528419001512 5.721644300818516 SQSSNDTFPTAMHIAAAIEVHEVLLPGLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQSSNDTFPTAMHIAAAIEVHEVLLPGLQK 30 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 108526000.0 18666000.0 50995000.0 38865000.0 False True 28317686.667389918 41894543.824246414 31183315.71486537 1.0 1.4794479618453908 1.1011957325869932 24.75520007759142 -9.993304052033372 5.096795686317428 0.9999978523896851 1.290321847218552 0.43992654608740234 0.15442082596709603 3.7685366759739246e-06 7.444499045484066e-07 0.14951842903288162 0.04983910727200161 1.0155374603869973e-10 9.993304052033372 0.29032399482886695 SQSSNDTFPTAMHIAAAIEVHEVLLPGLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQSSNDTFPTAMHIAAAIEVHEVLLPGLQK 30 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 56670000.0 18666000.0 16164000.0 21840000.0 False True 24163504.961868007 15264459.190702036 17865344.09732394 1.0 0.6317154409010863 0.7393523466697781 24.52632639968387 -10.385774243143016 8.569288862749062 1.0000017143358444 0.6855338937854328 0.9192282732239005 0.04394258277088833 1.4392204169163241e-06 1.031368964610008e-07 0.042547454812360025 0.01418240760508263 4.113635023102498e-11 10.385774243143016 -0.31446782055041156 SQTDQLVLIFAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQTDQLVLIFAGK 13 0 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 0 3665130.0 839530.0 1375600.0 1450000.0 False True 1100631.9600200846 1170365.8420468033 1299967.9093821447 1.0 1.0633580384358874 1.1811104498168694 20.06990069651952 -6.961453974199238 0.4144345695030689 0.994472531556799 1.2543975833219054 0.9998203725830171 0.0010057265580087232 0.07918576694232382 0.019242083278022907 0.0015186736832591419 0.009817799728877438 1.0928134355871684e-07 6.961453974199238 0.2599250517651064 SQTDQLVLIFAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQTDQLVLIFAGK 13 0 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 0 2712630.0 839530.0 1873100.0 0.0 False True 1149926.9284451837 1790340.2484866169 0.0 1.0 1.5569165346074085 0.0 20.133110758042413 -6.827909716027547 1.4580256959091131 1.3023072835694554 2.1116486430457925e-20 0.859128512260834 0.24176080431975203 0.19698453187455486 0.8395847757880682 0.13259991735657722 0.2881334914396657 1.4862445804010827e-07 6.827909716027547 -1.3023072835694554 down SQTDQLVLIFAGK(ub)ILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQTDQLVLIFAGKILK 16 1 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 1 78900000.0 15324000.0 40622000.0 22954000.0 True False 23247628.334462818 33372686.718865372 18417131.83890441 1.0 1.4355308093683232 0.7922155143715212 24.470580207759763 -6.724374102223959 1.7436250196553156 1.2637300372337816 0.7929673907137939 0.5330237990562464 0.18318205959867362 0.34690188718515375 2.063400530789359 0.08334443531793889 0.20815317033768804 1.886365729443472e-07 6.724374102223959 -0.4707626465199878 SQTDQLVLIFAGK(ub)ILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQTDQLVLIFAGKILK 16 1 Q9UHD9 Q9UHD9 UBQLN2 Ubiquilin-2 1 61493000.0 15324000.0 27464000.0 18705000.0 True False 19837220.08119925 25935604.25720371 15300881.929507548 1.0 1.307421309590864 0.771321882142598 24.241706529852213 -6.751196764540171 1.6455518143852654 1.1805063899729442 0.7701667856863477 0.6540649646634387 0.12918824511006352 0.29795472980194754 1.587789656103068 0.06201002185112914 0.15034685313142981 1.77338583607874e-07 6.751196764540171 -0.41033960428659655 SQTTYYAQCYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQTTYYAQCYR 11 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 0 8817500.0 1681400.0 3446200.0 3689900.0 False True 2204331.6827007607 2932040.3931823857 3308104.5440201163 1.0 1.3301266847419404 1.5007290282045969 21.071909889868834 -11.571940064172955 0.10918199062929307 7.300877362386765e-12 1.866871289053584 0.9998301125594119 0.0027091420109758356 4.565782828070906 0.07380407747160157 1.3517598222550793 0.2615328594530685 2.6795380952329475e-12 11.571940064172955 1.866871289046283 SQTTYYAQCYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQTTYYAQCYR 11 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 0 3580040.0 1998100.0 560040.0 1021900.0 False True 1934671.4092046428 783666.892570018 754233.7336571318 1.0 0.4050645959006491 0.3898510775880038 20.883657124548492 SQTTYYAQCYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQTTYYAQCYR 11 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 0 21169300.0 3639200.0 13531000.0 3999100.0 False True 5520932.461157477 11116287.331814457 3208676.132132199 1.0 2.0134800434569886 0.5811837320428825 22.396480521740177 -6.716615249637515 1.7715515357969522 1.6188003914889642 0.5838346591683338 0.49651279112027225 0.4266612300526034 0.361914871863773 2.21790754453195 0.19137278482400433 0.48233005270151424 1.92036928170367e-07 6.716615249637515 -1.0349657323206305 SQTTYYAQCYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQTTYYAQCYR 11 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 0 7033000.0 1681400.0 2244300.0 3107300.0 False True 2303059.0181264887 2145139.405092368 2373419.7368522966 1.0 0.9314304966606602 1.0305509837880948 21.135119951391726 -6.720601304105566 1.756994775550467 0.95830991856145 1.030403187839895 0.5153901777945998 0.028852253369788874 0.35416818839465114 2.1370114865544805 0.013036683408840987 0.03270575679244025 1.9028243304837823e-07 6.720601304105566 0.07209326927844495 SQTTYYAQCYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQTTYYAQCYR 11 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 0 10194400.0 3639200.0 3082600.0 3472600.0 False True 4711016.139356591 2911050.600176821 2840622.431884942 1.0 0.6179241407936249 0.60297446407664 22.167606843832626 SQTYESDGK(ub)NQANPSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQTYESDGKNQANPSR 16 1 Q13443 Q13443 ADAM9 Disintegrin and metalloproteinase domain-containing protein 9 1 5585160.0 1738600.0 1659100.0 2187460.0 True False 1683409.094661524 2321587.2820922043 1614498.6036066443 1.0 1.3790986929169442 0.9590649169750771 20.682954385991955 -6.668922252445961 1.9408647904347345 1.2421935780310982 0.9607571819221873 0.27445018399939747 0.16107153328193918 0.46357828544577484 3.3655252772319795 0.06683078426354598 0.1788278166982802 2.1432742565046915e-07 6.668922252445961 -0.2814363961089109 SQTYESDGK(ub)NQANPSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQTYESDGKNQANPSR 16 1 Q13443 Q13443 ADAM9 Disintegrin and metalloproteinase domain-containing protein 9 1 8049500.0 2515300.0 1812200.0 3722000.0 True False 3815893.993061493 1488798.7512167732 2986345.06858945 1.0 0.3901572616859593 0.7826069261933307 21.86358966262547 -9.92836237814166 5.476935851454237 1.0000005588674543 0.586382093938393 0.5969447059224843 0.1602169046328855 1.0933664265347427e-06 2.1398610307114476e-07 0.1551295612024616 0.0517097836180006 1.1793361792085283e-10 9.92836237814166 -0.4136184649290613 SQTYESDGK(ub)NQANPSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQTYESDGKNQANPSR 16 1 Q13443 Q13443 ADAM9 Disintegrin and metalloproteinase domain-containing protein 9 1 4672320.0 1738600.0 1944100.0 989620.0 True False 1445722.9330393332 1933626.7474263618 1196544.9665141064 1.0 1.3374808569725818 0.827644729961237 20.46335966142623 -6.728211905976814 1.7297542094861686 1.2034958185160713 0.8280450518871715 0.5509802069964206 0.1418896673726207 0.33958724855979056 1.9897268534874495 0.06502695222183415 0.1616873769061439 1.8697695981891344e-07 6.728211905976814 -0.37545076662889987 SQVFSTAADGQTQVEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQVFSTAADGQTQVEIK 17 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 13570500.0 2623600.0 6339100.0 4607800.0 False True 3439565.006978545 5393330.989618272 4131029.0571386465 1.0 1.5680270553618625 1.2010324121675817 21.71379469182239 -10.141005944917236 4.710455589610917 0.9999654318203145 1.3845297337684845 0.5941214543999975 0.14982493570636615 5.439558931516314e-05 9.919731592620565e-06 0.14508039173726203 0.04835579006795136 7.227599099069166e-11 10.141005944917236 0.38456430194817004 SQVFSTAADGQTQVEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQVFSTAADGQTQVEIK 17 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 10730900.0 3757200.0 1896800.0 5076900.0 False True 3637929.742587299 2654202.131681326 3747107.5862647016 1.0 0.7295913663779704 1.030010981905262 21.794686250576454 -6.669531382038298 1.9388656572118521 0.827329772941848 1.028798054320201 0.2770053960856256 0.11487616808811052 0.46221875931226564 3.3493802076358046 0.047704531717866004 0.1275403154512489 2.1402702656534134e-07 6.669531382038298 0.20146828137835315 SQVFSTAADGQTQVEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQVFSTAADGQTQVEIK 17 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 15311100.0 2623600.0 7075900.0 5611600.0 False True 3593615.8201241028 6763263.341127777 4286255.654529776 1.0 1.8820218074658333 1.1927417590180116 21.77700475334528 -10.24748790478024 4.845464764661577 0.9998786577348683 1.5373817832427419 0.4476437205838131 0.281397401432498 0.0003689488438630061 5.729892119195837e-05 0.2725228744442851 0.09082062078410673 5.6560350908178175e-11 10.24748790478024 0.5375031255078736 SQVFSTAADGQTQVEIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQVFSTAADGQTQVEIK 17 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 7057600.0 3757200.0 2069800.0 1230600.0 False True 3124278.27218186 2058649.5765768667 1487912.7703484753 1.0 0.6589200440008166 0.47624207600092605 21.57509152601073 -12.196753750355905 0.09330171099013572 2.2926884150905074 1.2924633313713803e-12 0.9998791052839123 0.002386596424672231 6.163315170231911 0.07083429247326248 1.9245507370306991 0.36067606472015246 6.356912734751761e-13 12.196753750355905 -2.292688415089215 SQVVAGTNYFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQVVAGTNYFIK 12 0 P04080;A0A1W2PS52 P04080 CSTB Cystatin-B 0 597290000.0 167610000.0 178880000.0 250800000.0 False True 219738333.13754892 152191801.26877895 224849621.84347716 1.0 0.6926046953014425 1.0232607967528757 27.711211327555507 -10.147020651335481 13.026686808838972 1.0000000000011082 0.8579327460271591 0.19751881984286168 0.13498978814899326 0.0 0.0 0.13070330035227953 0.04356776678409317 7.128191337320647e-11 10.147020651335481 -0.14206725397394915 SQVVAGTNYFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQVVAGTNYFIK 12 0 P04080;A0A1W2PS52 P04080 CSTB Cystatin-B 0 431147000.0 130260000.0 57537000.0 243350000.0 False True 126124967.60071905 80511824.15149127 179609334.6564861 1.0 0.6383496121590462 1.4240585196825226 26.910278657827654 -6.781544759488254 1.5297266650476422 0.7956322039200655 1.4305991112609675 0.7728364672000679 0.15304231904461177 0.24819450220467829 1.1472449980001607 0.07878767843189638 0.1856769989924038 1.6536943420649108e-07 6.781544759488254 0.634966907340902 SQVVAGTNYFIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQVVAGTNYFIK 12 0 P04080;A0A1W2PS52 P04080 CSTB Cystatin-B 0 624320000.0 103010000.0 405610000.0 115700000.0 False True 156273701.0397428 333225726.45460576 92831844.2868884 1.0 2.132321204639937 0.5940336964520975 27.219499769861937 -6.709463626561923 1.79712775303548 1.696505188283812 0.5977054483060181 0.4625574051547279 0.47719360346812945 0.37615047275763475 2.36779582807107 0.21133487010168864 0.5372371805598269 1.9522542342209153e-07 6.709463626561923 -1.0987997399777938 SQVVAGTNYFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQVVAGTNYFIK 12 0 P04080;A0A1W2PS52 P04080 CSTB Cystatin-B 0 553070000.0 167610000.0 213440000.0 172020000.0 False True 229579946.48993757 204009515.04830685 131392418.863107 1.0 0.8886207971010592 0.57231661942593 27.774421389078398 -6.952676887669956 0.5286403509594864 1.0050377889744624 0.44157403994436456 0.9993949537063949 0.004456085073547871 0.08242833009955343 0.031649207869169256 0.0049814564456763764 0.02615214039415716 1.1151238701039938e-07 6.952676887669956 -0.5634637490300978 SQVVAGTNYFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQVVAGTNYFIK 12 0 P04080;A0A1W2PS52 P04080 CSTB Cystatin-B 0 322120000.0 130260000.0 124880000.0 66980000.0 False True 108316961.49643596 124207246.65326084 80985208.31947085 1.0 1.146701725540443 0.747668760281238 26.69068393326193 -6.8071724153125075 1.426209593127456 1.0802227855230093 0.7411184974524866 0.8523634854892941 0.06332042054262674 0.21067926582481108 0.845095427003617 0.03491416796649271 0.08087859052582368 1.558933481919536e-07 6.8071724153125075 -0.33910428807052273 SQVVAGTNYFIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQVVAGTNYFIK 12 0 P04080;A0A1W2PS52 P04080 CSTB Cystatin-B 0 385130000.0 103010000.0 169290000.0 112830000.0 False True 133348475.63066682 159868862.68212995 92296097.73356509 1.0 1.1988803165993156 0.6921421283374558 26.990626091954386 -6.800249994301906 1.45491819840839 1.1096966847527463 0.6851059842268488 0.8328831452501849 0.08521974722038281 0.22040289365534496 0.9210553683369253 0.0460792584009022 0.1071458155921048 1.5839811379253233e-07 6.800249994301906 -0.42459070052589754 SQWSPALTISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SQWSPALTISK 11 0 P61077;P61077-3;P61077-2;D6RAH7;H9KV45;A0A0A0MQU3;A0A087WY85;P62837-2;P62837;D6RAW0;D6RFM0 P61077 UBE2D3;UBE2D2 Ubiquitin-conjugating enzyme E2 D3;Ubiquitin-conjugating enzyme E2 D2 0 97207000.0 20930000.0 35242000.0 41035000.0 False True 27439432.68640833 29984030.972240046 36789091.835514665 1.0 1.0927350909515028 1.3407380632084838 24.70974731813603 -6.954001667113912 0.513035657433508 0.9955472678501553 1.4488626064204446 0.9994790491777786 0.0032830330503317807 0.08191757105394892 0.029612005734942496 0.003761894920146886 0.02047271221695084 1.1117274597167259e-07 6.954001667113912 0.4533153385702893 SQWSPALTISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQWSPALTISK 11 0 P61077;P61077-3;P61077-2;D6RAH7;H9KV45;A0A0A0MQU3;A0A087WY85;P62837-2;P62837;D6RAW0;D6RFM0 P61077 UBE2D3;UBE2D2 Ubiquitin-conjugating enzyme E2 D3;Ubiquitin-conjugating enzyme E2 D2 0 49285100.0 15200000.0 8060100.0 26025000.0 False True 14717484.320059348 11278539.962866224 19208271.766735375 1.0 0.7663361290281125 1.305132816792287 23.8110277548223 -6.788891740084022 1.5012595639635868 0.8692151338478888 1.3106492878581886 0.7975497069179425 0.099260928209168 0.2370148178736779 1.0553886116106852 0.05205166250636777 0.12193856627932857 1.6259540192641482e-07 6.788891740084022 0.44143415401029973 SQWSPALTISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQWSPALTISK 11 0 P61077;P61077-3;P61077-2;D6RAH7;H9KV45;A0A0A0MQU3;A0A087WY85;P62837-2;P62837;D6RAW0;D6RFM0 P61077 UBE2D3;UBE2D2 Ubiquitin-conjugating enzyme E2 D3;Ubiquitin-conjugating enzyme E2 D2 0 88277000.0 20872000.0 54494000.0 12911000.0 False True 31664349.94759253 44769119.93643471 10359135.19090766 1.0 1.4138651199387262 0.32715451945336005 24.916356126153335 -6.803476938271851 1.4415781594847574 1.2273448232469162 0.3108118807334305 0.8421833564214258 0.1779045967816272 0.21581569573383405 0.8850295572617509 0.09706874566216943 0.22529509878307993 1.5722552795037858e-07 6.803476938271851 -0.9165329425134856 down SQWSPALTISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQWSPALTISK 11 0 P61077;P61077-3;P61077-2;D6RAH7;H9KV45;A0A0A0MQU3;A0A087WY85;P62837-2;P62837;D6RAW0;D6RFM0 P61077 UBE2D3;UBE2D2 Ubiquitin-conjugating enzyme E2 D3;Ubiquitin-conjugating enzyme E2 D2 0 74459000.0 20930000.0 22058000.0 31471000.0 False True 28668386.611982547 21083404.623948403 24038197.965590287 1.0 0.7354234791551247 0.8384914816079334 24.772957379658923 -10.200864261821406 5.404217620513659 1.0000102273404354 0.7869574804568037 0.8506727897577055 0.04207733580299543 5.185213060944447e-06 7.667145255744154e-07 0.04074316065726158 0.013580401734798795 6.29702964950826e-11 10.200864261821406 -0.21305274688363174 SQWSPALTISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQWSPALTISK 11 0 P61077;P61077-3;P61077-2;D6RAH7;H9KV45;A0A0A0MQU3;A0A087WY85;P62837-2;P62837;D6RAW0;D6RFM0 P61077 UBE2D3;UBE2D2 Ubiquitin-conjugating enzyme E2 D3;Ubiquitin-conjugating enzyme E2 D2 0 35960400.0 15200000.0 11200000.0 9560400.0 False True 12639473.474173404 11139663.376974048 11559435.437704831 1.0 0.881339195001757 0.9145503933628687 23.591433030256578 -10.825966607788274 6.9469266541864085 1.0063072194756308 0.8979447941820059 0.9264187053714594 0.01355841495518012 0.00139240545218623 3.488230617411443e-05 0.013801264155522599 0.004375959610198511 1.492909192578711e-11 10.825966607788274 -0.10836242529362494 SQWSPALTISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQWSPALTISK 11 0 P61077;P61077-3;P61077-2;D6RAH7;H9KV45;A0A0A0MQU3;A0A087WY85;P62837-2;P62837;D6RAW0;D6RFM0 P61077 UBE2D3;UBE2D2 Ubiquitin-conjugating enzyme E2 D3;Ubiquitin-conjugating enzyme E2 D2 0 54105000.0 20872000.0 20266000.0 12967000.0 False True 27019215.448629 19138179.28475426 10607139.05265566 1.0 0.7083173573689152 0.39257761102733585 24.687482448245785 -6.975421222985817 0.2560977273598661 1.093236500012555 4.153779090363001e-11 0.9999833460069238 0.0010122337270013105 0.07560133339375369 0.008889378522357017 0.0067498508854234775 0.02974668421233328 1.0582268511804631e-07 6.975421222985817 -1.0932364999710171 down SQYDYILPQVSFTAVGYHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SQYDYILPQVSFTAVGYHK 19 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;H3BUC9;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 26878500.0 9903400.0 6766100.0 10209000.0 False True 9589021.98784709 9467839.014745371 7534956.636564899 1.0 0.9873623219077708 0.7857899007964038 23.19295224742106 -6.919693904981212 0.827002382835193 1.0044968314757967 0.7535132051946333 0.994095287872213 0.007541022140784039 0.0983521622503016 0.10655283059956255 0.0064868490350397795 0.019374451117614336 1.2031121010926857e-07 6.919693904981212 -0.25098362628116344 SQYDYILPQVSFTAVGYHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SQYDYILPQVSFTAVGYHK 19 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;H3BUC9;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 82697000.0 23240000.0 24085000.0 35372000.0 False True 35256779.07158161 19786843.573036082 28380708.69590166 1.0 0.5612209649912427 0.8049716804328748 25.071397345627776 -10.123906417393865 5.312214014562781 1.0000070296009342 0.6830963227118663 0.6926602317189391 0.09951081287906471 8.284883839234275e-06 1.3662837096177037e-06 0.09635306738300584 0.03211697675391761 7.517848726090034e-11 10.123906417393865 -0.316910706889068 SQYDYILPQVSFTAVGYHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SQYDYILPQVSFTAVGYHK 19 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;H3BUC9;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 8450300.0 1250300.0 1332900.0 5867100.0 False True 1712569.6980870413 1274008.070689132 4481411.816717446 1.0 0.7439160415556884 2.616776310898897 20.707731273332143 -6.8723598618823125 1.1214823461604568 0.8528669501889127 2.7315203024196544 0.9669848648521298 0.15065398193684607 0.1346150622855138 0.3149924189956343 0.10409427028142057 0.24751877131778424 1.34165279000765e-07 6.8723598618823125 1.8786533522307418 up SQYDYILPQVSFTAVGYHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SQYDYILPQVSFTAVGYHK 19 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;H3BUC9;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 20073900.0 9903400.0 3683900.0 6486600.0 False True 8235115.895008479 3664054.099503099 7842918.0693502575 1.0 0.4449304838228177 0.9523749476439132 22.973357522855338 -10.517927315848025 9.152868262539462 1.0000116605627651 0.6986527157333661 0.31982726378127313 0.2071633348603138 4.929554116326474e-05 2.5963434902156538e-06 0.20059278684631027 0.06686167882156548 3.0343989830981195e-11 10.517927315848025 -0.30135894482939907 SQYDYILPQVSFTAVGYHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SQYDYILPQVSFTAVGYHK 19 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;H3BUC9;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3;A0A087WTD5 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 77503000.0 23240000.0 30784000.0 23479000.0 False True 30084638.12888745 29070843.33868917 19206062.9148841 1.0 0.9663019117645685 0.6384009949729901 24.842523667720226 -6.926645654314632 0.7738311153794637 1.0056552808538792 0.5764955953096947 0.995836883833503 0.010523438047495507 0.09441743414688622 0.08649017595760257 0.009402529319798573 0.030235074264598465 1.1840072063427907e-07 6.926645654314632 -0.4291596855441845 SRDPIIFSVGWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SRDPIIFSVGWR 12 1 Q14692 Q14692 BMS1 Ribosome biogenesis protein BMS1 homolog 0 5352600.0 1357900.0 2179500.0 1815200.0 False True 1780220.049922304 1854327.09562446 1627380.5166279082 1.0 1.0416280255384105 0.9141457072674435 20.76362415057776 -6.8187453989470805 1.3771811328235122 1.0224662994359897 0.911434236874763 0.8815002034773183 0.01827150913133097 0.195114867757144 0.727468321324124 0.010426444890712148 0.024041005897518265 1.517939984699859e-07 6.8187453989470805 -0.11103206256122666 SRDPIIFSVGWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SRDPIIFSVGWR 12 1 Q14692 Q14692 BMS1 Ribosome biogenesis protein BMS1 homolog 0 6560200.0 1741200.0 1998100.0 2820900.0 False True 1685926.5590846934 2795951.749953847 2082021.664813979 1.0 1.658406610233246 1.2349420878358601 20.68511026150453 -10.19105495002696 4.488888395727159 0.9998955982281293 1.4466743490423333 0.5973419889500902 0.17287866736747404 121423384.9613019 25.64572129749281 131034.19353563004 0.05918096613890904 6.4408776579384e-11 10.19105495002696 0.44677875081420393 SRDPIIFSVGWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SRDPIIFSVGWR 12 1 Q14692 Q14692 BMS1 Ribosome biogenesis protein BMS1 homolog 0 18875400.0 4147000.0 4945300.0 9783100.0 False True 6291302.186310191 4062772.5771947457 7849465.996914941 1.0 0.6457760979968976 1.247669522852566 22.584927229241845 -6.747243650116927 1.6602930335456603 0.7910229328933864 1.248601321673262 0.6369360932697625 0.14883059998681547 0.30487110138858015 1.6526481950735328 0.07084292196438476 0.17247149682303964 1.7896015609015572e-07 6.747243650116927 0.45757838877987567 SRDPIIFSVGWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SRDPIIFSVGWR 12 1 Q14692 Q14692 BMS1 Ribosome biogenesis protein BMS1 homolog 0 5417600.0 1357900.0 1836400.0 2223300.0 False True 1859952.3258677043 1755261.7758372857 1698202.3303008142 1.0 0.9437133153498553 0.9130354077804491 20.82683421210065 -13.99999999995582 0.07377136614153187 1.3163920308214727 0.8098486765714221 0.9999110343655375 0.00033962750962178326 12.321236184361723 0.07455895194933476 0.6563738135846614 0.09449959072876275 1.0000000001017277e-14 13.99999999995582 -0.5065433542500506 SRDPIIFSVGWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SRDPIIFSVGWR 12 1 Q14692 Q14692 BMS1 Ribosome biogenesis protein BMS1 homolog 0 3350210.0 1741200.0 831860.0 777150.0 False True 1447884.948238864 827378.6050687185 939648.4718643893 1.0 0.571439468360453 0.6489800677929081 20.465515536938806 -10.791615446220487 7.137618103250407 1.012689999006034 0.6102097680766805 0.9711759113672151 0.03165581715984296 0.006325591234090113 0.0001846769711257542 0.03032983153443362 0.01021687105588823 1.615788652404826e-11 10.791615446220487 -0.4024802309293536 SRDPIIFSVGWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SRDPIIFSVGWR 12 1 Q14692 Q14692 BMS1 Ribosome biogenesis protein BMS1 homolog 0 19707000.0 4147000.0 6707600.0 8852400.0 False True 5368373.249591056 6334316.163545727 7241354.0332944365 1.0 1.1799321449990932 1.3488916840583052 22.356053551334295 -6.971884936260365 0.2083024963499196 0.9096014648749714 1.6239301093356793 0.9999935893867969 0.00036064566614081735 0.0756957004522576 0.006796058805175017 0.005128425114667136 0.01757772355229763 1.0668787469664165e-07 6.971884936260365 0.7143286444607079 SRFDRPPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SRFDRPPAR 9 2 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629;F8WEA1 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 13233600.0 2022400.0 7072900.0 4138300.0 False True 2651385.9849494593 6017650.889948257 3710108.4133766354 1.0 2.269624612978772 1.3993090536183692 21.3383152802827 -10.141809327746556 5.2511676539329075 0.9999740041535302 1.8344668332991223 0.5507140965664091 0.35530483927491424 248346675.87391728 5.896042922763235 78061.3509486035 0.12163029703821641 7.214241430620432e-11 10.141809327746556 0.8344928291455921 SRFDRPPAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SRFDRPPAR 9 2 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629;F8WEA1 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 12050800.0 4543200.0 2477300.0 5030300.0 False True 4398978.602821951 3466498.8089488377 3712713.5242347345 1.0 0.788023566817323 0.8439944494963043 22.06873715314149 -9.223644094251782 10.111775971534186 0.9999989329198389 0.8160090079411255 0.9350991835880369 0.0228500171777847 0.0 0.0 0.022124433993761315 0.00737481133125377 5.975247594886412e-10 9.223644094251782 -0.18398992497871336 SRFDRPPAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SRFDRPPAR 9 2 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629;F8WEA1 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 23869700.0 2596700.0 17245000.0 4028000.0 False True 3939383.7441986185 14167495.014200013 3231864.0344648813 1.0 3.596373426443653 0.820398378102749 21.909538529278535 -6.661229202915052 1.9685108656984842 2.6695673773905257 0.8319491056775699 0.2408343451163104 1.1051546156224599 0.4815480504816538 3.5884224549718597 0.45337317742434985 1.225303603293999 2.1815782599413262e-07 6.661229202915052 -1.8376182717129559 SRFDRPPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SRFDRPPAR 9 2 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629;F8WEA1 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 12488700.0 2022400.0 5543200.0 4923100.0 False True 2770135.9333049916 5298283.095088901 3760365.174427175 1.0 1.912643719533153 1.3574659384822179 21.40152534180559 -10.36410566644843 5.821345962635514 0.999873802627912 1.6350548290076867 0.6356488006169365 0.2266503800175695 0.00037129306848999983 4.055821755914841e-05 0.21949626074886833 0.07315109560163509 4.3240861063049635e-11 10.36410566644843 0.6351810263797747 SRFDRPPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SRFDRPPAR 9 2 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629;F8WEA1 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 8113600.0 2596700.0 1871800.0 3645100.0 False True 3361479.338609379 1767632.68455556 2981729.201884408 1.0 0.5258496353830981 0.8870288648324488 21.680664851370985 -9.779451594965245 6.128126844868779 1.0000000097279769 0.7064392501073558 0.46831816381307956 0.14745080297524524 1.946979857390417e-08 3.992298635326156e-09 0.142768631394895 0.04758954202545061 1.6616838732658118e-10 9.779451594965245 -0.2935607596206211 SRFWYFVSQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SRFWYFVSQLK 11 1 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 106197000.0 26519000.0 25336000.0 54342000.0 False True 40231261.79859175 20814592.84892848 43601279.88105533 1.0 0.5173736024768946 1.083766154274126 25.26181365104467 -6.6810462170667595 1.8986772622951196 0.6949193328468396 1.081603527579095 0.3287673688531926 0.20450229502222195 0.4361598902533323 3.0410133941993633 0.08640774383141028 0.22754733601120605 2.0842690660299306e-07 6.6810462170667595 0.38668419473225535 SRFWYFVSQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SRFWYFVSQLK 11 1 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 21671900.0 6591100.0 5988400.0 9092400.0 False True 5480791.685238447 5956139.30059567 10993578.80149236 1.0 1.0867297358951788 2.005837738934986 22.385952870880875 -6.925265908846401 0.784671458935748 0.9833034486550616 2.1736317299334775 0.9955233309753977 0.030449358750011573 0.09517137753204521 0.09027427751365334 0.026995882403075475 0.08543001640052386 1.1877747567021e-07 6.925265908846401 1.190328281278416 up SRFWYFVSQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SRFWYFVSQLK 11 1 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 109046800.0 26519000.0 38895000.0 43632800.0 False True 34329368.26764052 36730459.05854711 35692078.11033496 1.0 1.0699427607343972 1.0396951622316615 25.03293997313712 -10.242211428462207 4.1739767016784475 0.9999623350374084 1.054818961485954 0.8141069987045748 0.0123485303891789 4.331153365201714e-06 7.863475822466656e-07 0.011964626928261704 0.003985471044264504 5.7251724340084164e-11 10.242211428462207 0.05485662644854561 SRFWYFVSQLKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SRFWYFVSQLKK 12 2 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 41085500.0 12174000.0 7347500.0 21564000.0 False True 15960231.893183704 6251281.640330684 19332764.13649419 1.0 0.39167862235137585 1.2113084738293074 23.927978277470775 -6.707894610620361 1.8023390923765668 0.6252326462214124 1.2092998008435285 0.45531985081544046 0.2564272867588309 0.37929532135843785 2.4003801312070867 0.11326869228365276 0.2885327112321502 1.9593200801343144e-07 6.707894610620361 0.5840671546221161 SRFWYFVSQLKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SRFWYFVSQLKK 12 2 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 27884100.0 6671200.0 5275900.0 15937000.0 False True 6459426.4076302545 7382594.3834550325 11762621.60024829 1.0 1.142917949298761 1.8210009462068628 22.622974629660128 -6.9409822487898305 0.6503685084197235 0.9924989260106792 2.009261616511465 0.9982896630628397 0.014810586144267815 0.0873214960795907 0.05259181597889186 0.014526578845902546 0.058113349874177454 1.1455597637225758e-07 6.9409822487898305 1.0167626905007858 SRFWYFVSQLKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SRFWYFVSQLKK 12 2 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 45244000.0 11542000.0 1510000.0 32192000.0 False True 17510057.833226956 1240528.7023161503 25829237.089745183 1.0 0.07084663649494818 1.4751086110482063 24.061680513007104 -6.7283007748192185 1.7295043508789418 0.43977369296475366 1.474002072963385 0.5513023185257739 0.39064991879192557 0.3394496332576872 1.9884019851683914 0.17905668070500708 0.4451609881155164 1.8693870299850696e-07 6.7283007748192185 1.0342283799986314 SRFWYFVSQLKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SRFWYFVSQLKK 12 2 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 77203000.0 12174000.0 53254000.0 11775000.0 False True 16675056.789979717 50901062.192571856 8993987.513737267 1.0 3.0525270668438766 0.5393677291187329 23.991188338993666 -6.689543703683886 1.8675216673732078 2.287325448519115 0.5479825256680783 0.36847798463841175 0.8681519426017383 0.41767581934060843 2.823801659402213 0.37189343363330724 0.9691778647385207 2.043884246615681e-07 6.689543703683886 -1.7393429228510366 SRFWYFVSQLKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SRFWYFVSQLKK 12 2 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 20641700.0 6671200.0 9367500.0 4603000.0 False True 5547398.384270103 9317035.418196838 5565466.018132654 1.0 1.679532417324797 1.0032569562542655 22.403379905094404 -10.211883609978434 3.9957811906371963 0.9998084331237372 1.3413946857207053 0.25361192222371365 0.27608830261058326 195846296.39117038 233067688.11085686 534152.6332012016 0.10103798407998371 6.139265141539e-11 10.211883609978434 0.34158625259696807 SRFWYFVSQLKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SRFWYFVSQLKK 12 2 Q02543;M0R3D6;M0R1A7;M0R117 Q02543 RPL18A 60S ribosomal protein L18a 0 70325000.0 11542000.0 23042000.0 35741000.0 False True 14941346.526833843 21759692.44445411 29236504.733628936 1.0 1.4563407926705194 1.9567516676707664 23.832806835099554 -6.9699413627158 0.2595824855534177 0.8587911709435873 2.569139650650069 0.9999819217723879 0.0016613166840399839 0.07632174904647085 0.009098186097370202 0.010474436602274772 0.04724417710653411 1.0716639886873672e-07 6.9699413627158 1.7103484797064819 SRGFGFVLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SRGFGFVLFK 10 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RBQ9;A0A087WUK2;O14979-3;O14979-2;O14979;D6RF44 Q14103-3;Q14103-4;A0A087WUK2;D6RF44 HNRNPD;HNRNPDL Heterogeneous nuclear ribonucleoprotein D0;Heterogeneous nuclear ribonucleoprotein D-like 0 93195400.0 55518000.0 6069400.0 31608000.0 False True 72784635.63707674 5163869.178335902 28337507.365345407 1.0 0.07094724227355217 0.3893336432519034 26.117130603240042 -10.462381194062734 6.055278689711671 1.0004275430048082 0.23014044542633622 0.8863075277154117 0.1299807039063543 0.0007506202475183301 6.664363483595952e-05 0.12591866005202276 0.041951091796468915 3.448409286246015e-11 10.462381194062734 -0.7702870975784719 SRGFGFVLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SRGFGFVLFK 10 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RBQ9;A0A087WUK2;O14979-3;O14979-2;O14979;D6RF44 Q14103-3;Q14103-4;A0A087WUK2;D6RF44 HNRNPD;HNRNPDL Heterogeneous nuclear ribonucleoprotein D0;Heterogeneous nuclear ribonucleoprotein D-like 0 16134400.0 6410600.0 3301200.0 6422600.0 False True 6207099.011985034 4619386.375530575 4740328.386130056 1.0 0.7442101965203376 0.7636946626720711 22.56548772844778 -10.569969093139976 6.335496935813084 1.0004640444557529 0.7539524295962043 0.9953187424566453 0.007954499997046203 5.2234011452954635e-05 3.5454597808858148e-06 0.007716083580072613 0.002567303834663906 2.6917263556343323e-11 10.569969093139976 -0.24651161485954853 SRGFGFVLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SRGFGFVLFK 10 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RBQ9;A0A087WUK2;O14979-3;O14979-2;O14979;D6RF44 Q14103-3;Q14103-4;A0A087WUK2;D6RF44 HNRNPD;HNRNPDL Heterogeneous nuclear ribonucleoprotein D0;Heterogeneous nuclear ribonucleoprotein D-like 0 152512000.0 55518000.0 83460000.0 13534000.0 False True 76044504.91753681 79772461.23468745 10337547.941479426 1.0 1.0490233491715577 0.13594076196155835 26.180340664762934 -6.894216490548068 0.997086283103226 1.0442177436259243 0.05059382654171544 0.9834633383096109 0.05392683227134282 0.11578940213216224 0.2023881118692143 0.040963484056696836 0.1038032449533662 1.2758026780638007e-07 6.894216490548068 -0.9936239170842089 down SRGFGFVLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SRGFGFVLFK 10 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RBQ9;A0A087WUK2;O14979-3;O14979-2;O14979;D6RF44 Q14103-3;Q14103-4;A0A087WUK2;D6RF44 HNRNPD;HNRNPDL Heterogeneous nuclear ribonucleoprotein D0;Heterogeneous nuclear ribonucleoprotein D-like 0 12295500.0 6410600.0 3102700.0 2782200.0 False True 5330697.937732636 3085985.139262271 3363945.1565606496 1.0 0.5789082734211098 0.6310515425662016 22.345893003882058 -10.096267413746387 4.832687583582124 1.000016193351203 0.604979907992 0.987100267458041 0.021287400504097907 3.887703738927271e-06 7.270193901625984e-07 0.020612320562153945 0.006870478967328363 8.011845877498304e-11 10.096267413746387 -0.3950362853592031 SRGFGFVLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SRGFGFVLFK 10 1 Q14103-3;Q14103;H0YA96;H0Y8G5;D6RAF8;Q14103-4;Q14103-2;D6RBQ9;A0A087WUK2;O14979-3;O14979-2;O14979;D6RF44 Q14103-3;Q14103-4;A0A087WUK2;D6RF44 HNRNPD;HNRNPDL Heterogeneous nuclear ribonucleoprotein D0;Heterogeneous nuclear ribonucleoprotein D-like 0 25333700.0 3921300.0 9126400.0 12286000.0 False True 5076200.150378927 8618507.817249635 10050074.065005578 1.0 1.6978266344770279 1.9798419619556102 22.27531752389845 -10.533830505478344 0.1924940458680324 3.2133645035361532e-12 2.2328705617884705 0.9994300673005438 0.009832205407841237 2.2988196500850675 0.09938406474376356 1.2742768423246058 0.1829512249876122 2.9252938257720623e-11 10.533830505478344 2.232870561785257 SRPAHLGVFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SRPAHLGVFLR 11 1 O15085;O15085-2 O15085 ARHGEF11 Rho guanine nucleotide exchange factor 11 0 3240150.0 960240.0 715210.0 1564700.0 False True 1258883.9389773884 608503.4558667438 1402799.8536622361 1.0 0.4833673995086798 1.114320240515383 20.263713851284994 -6.689115993052706 1.870086117334522 0.6758281968829085 1.1120859943962502 0.36609908954223647 0.21853945319966386 0.418544900764903 2.83738650846015 0.09352262373966219 0.24376362811087426 2.0458981373468995e-07 6.689115993052706 0.4362577975133417 SSACFTLQELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSACFTLQELK 11 0 P46060;H0Y4Q3 P46060 RANGAP1 Ran GTPase-activating protein 1 0 42240000.0 13667000.0 11746000.0 16827000.0 False True 17917569.35141627 9993542.585549396 15085903.45598161 1.0 0.5577510202163369 0.8419614937775678 24.094871602806787 -10.095235621156034 5.126524862551455 1.000006902910003 0.6998562569963143 0.597912558978458 0.11602843996552066 9.154371369296176e-06 1.6155076329550495e-06 0.11234663626270568 0.03744801797242141 8.030902971584555e-11 10.095235621156034 -0.3001506459136887 SSACFTLQELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSACFTLQELK 11 0 P46060;H0Y4Q3 P46060 RANGAP1 Ran GTPase-activating protein 1 0 12058600.0 6198400.0 2714400.0 3145800.0 False True 6001635.184832628 3798274.075409005 2321820.608022905 1.0 0.6328732017914098 0.38686466879736797 22.516924195319884 -8.25357611802586 0.17096742061766484 1.33879407966254 1.229576462394825e-10 0.9998774994161467 0.002788400434311463 0.08748576713613608 0.03609160610635485 0.12058158572852797 0.12451318070877186 5.577298412512454e-09 8.25357611802586 -1.3387940795395823 down SSACFTLQELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSACFTLQELK 11 0 P46060;H0Y4Q3 P46060 RANGAP1 Ran GTPase-activating protein 1 0 62575000.0 12071000.0 30152000.0 20352000.0 False True 18312589.50830727 24771140.021348763 16329418.279401528 1.0 1.3526836283919133 0.8917044895258476 24.12633247537102 -6.702235102912186 1.8226202415756851 1.2185183498618941 0.8930044189811936 0.428295435733547 0.14881197307406732 0.3909040725124243 2.526046809877414 0.06509442880998914 0.1669626578004222 1.9850200468388498e-07 6.702235102912186 -0.32551393088070046 SSACFTLQELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSACFTLQELK 11 0 P46060;H0Y4Q3 P46060 RANGAP1 Ran GTPase-activating protein 1 0 40052000.0 13667000.0 11415000.0 14970000.0 False True 18720059.236787643 10910647.55564291 11434394.316827755 1.0 0.5828318926577913 0.6108097294028592 24.15808166432968 -10.745363867336811 6.892826432942776 1.0070849275447278 0.5968208110305008 0.9964014480729609 0.01142190402205099 0.0012496299348235445 4.616400141353855e-05 0.011113027971166973 0.0036864036716152495 1.797364388405074e-11 10.745363867336811 -0.410264116514227 SSACFTLQELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSACFTLQELK 11 0 P46060;H0Y4Q3 P46060 RANGAP1 Ran GTPase-activating protein 1 0 14241800.0 6198400.0 2094800.0 5948600.0 False True 5154244.235678717 2083514.896614754 7192424.756781198 1.0 0.4042328615691597 1.3954373188204365 22.29732947075416 -6.7439475359571475 1.6722911161229317 0.6471522907006486 1.3965286120289326 0.6225219283274173 0.2503053732983542 0.31071433316805214 1.707589636629643 0.11834166663394166 0.28914570954072705 1.8032355638294293e-07 6.7439475359571475 0.749376321328284 SSACFTLQELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSACFTLQELK 11 0 P46060;H0Y4Q3 P46060 RANGAP1 Ran GTPase-activating protein 1 0 51223000.0 12071000.0 27657000.0 11495000.0 False True 15626147.45498278 26117863.63754308 9403027.948660195 1.0 1.6714205284946775 0.6017495979574805 23.897458797463468 -6.737046339791103 1.697815257459865 1.4008591942852018 0.6015538514236588 0.5914903721162471 0.28212771882735926 0.32318033583410205 1.8280656021850608 0.1315292702677652 0.3237754032881225 1.8321189224482044e-07 6.737046339791103 -0.799305342861543 SSAK(ub)ILADQQDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSAKILADQQDK 12 1 Q9Y265;H7C4G5 Q9Y265 RUVBL1 RuvB-like 1 1 4418670.0 1393100.0 2202000.0 823570.0 True False 1348876.803044388 3081270.083278302 607852.3104295962 1.0 2.2843228353574894 0.4506358987401115 20.36332715797119 -6.718440489872135 1.7651062299731626 1.7826648126429867 0.4537743247110054 0.5050951298980655 0.5405524911122461 0.3583422014634201 2.1810950963165303 0.24325221866077737 0.6117355992427738 1.912315345741921e-07 6.718440489872135 -1.3288904879319814 SSAK(ub)ILADQQDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSAKILADQQDK 12 1 Q9Y265;H7C4G5 Q9Y265 RUVBL1 RuvB-like 1 1 4306800.0 1400600.0 1152200.0 1754000.0 True False 2124812.597575611 946580.9078203111 1407321.1311944907 1.0 0.44548912638241606 0.6623271778415798 21.01890417458832 -10.204211807562194 5.445153012999346 1.0000207126569842 0.5539081521119488 0.8494674478733212 0.08852376381589991 2.2260199024726513e-05 3.253191794558733e-06 0.08571673977557236 0.02857092191685535 6.248678673064948e-11 10.204211807562194 -0.44611256054503545 SSAK(ub)ILADQQDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSAKILADQQDK 12 1 Q9Y265;H7C4G5 Q9Y265 RUVBL1 RuvB-like 1 1 4684400.0 1400600.0 1756900.0 1526900.0 True False 1813104.309953518 1659126.9705607798 1249019.8673170307 1.0 0.9150753001096305 0.6888847268522854 20.79003049668077 -6.954090856422223 0.5119675051009374 1.0040964121394715 0.5899069494745222 0.9994844425903865 0.002981372629754267 0.08188346847642042 0.029477041199046896 0.0034224095908060065 0.01867060764971741 1.1114991721686673e-07 6.954090856422223 -0.4141894626649494 SSAQDPQAVLGALGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSAQDPQAVLGALGR 15 0 P26640;A0A140T936;A0A140T954;A2ABF4;A0A0G2JJT9;A0A140T904 P26640 VARS Valine--tRNA ligase 0 15713900.0 0.0 7728700.0 7985200.0 False True 0.0 6575608.086236646 7158968.103447105 0.0 SSAQDPQAVLGALGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSAQDPQAVLGALGR 15 0 P26640;A0A140T936;A0A140T954;A2ABF4;A0A0G2JJT9;A0A140T904 P26640 VARS Valine--tRNA ligase 0 14278800.0 4334300.0 0.0 9944500.0 False True 4196710.018975873 0.0 7339737.121394804 1.0 0.0 1.7489264419527197 22.00082734976537 -6.751595873470908 1.6439118855733776 0.4131581260423571 1.7528541763969834 0.6559435267112756 0.4202400317879382 0.29720590973048366 1.580733890123818 0.2019009055632155 0.48934748693357816 1.7717568745377516e-07 6.751595873470908 1.3396960503546262 SSAQDPQAVLGALGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSAQDPQAVLGALGR 15 0 P26640;A0A140T936;A0A140T954;A2ABF4;A0A0G2JJT9;A0A140T904 P26640 VARS Valine--tRNA ligase 0 14999800.0 0.0 9042800.0 5957000.0 False True 0.0 8643259.195459269 4550079.288266059 0.0 SSASFSTTAVSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSASFSTTAVSAR 13 0 A0A0D9SG72;P61764;A0A1B0GWF2;A0A1B0GVQ5;A0A2R8Y5D4;A0A1B0GTP9;P61764-2;A0A096LP52 A0A0D9SG72 STXBP1 Syntaxin-binding protein 1 0 6026300.0 2016400.0 1638300.0 2371600.0 False True 2643519.9268453782 1393872.0260433827 2126209.581993581 1.0 0.5272788042520065 0.8043100263408548 21.334028771114962 -10.240196303470249 5.734229140631772 1.0000146934982317 0.6657944152964259 0.6599192283788975 0.11309752282290654 2.1245857798861203e-05 2.815179464084524e-06 0.10951101690830385 0.03650206853253303 5.751798941275145e-11 10.240196303470249 -0.3342202782018058 SSASFSTTAVSAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSASFSTTAVSAR 13 0 A0A0D9SG72;P61764;A0A1B0GWF2;A0A1B0GVQ5;A0A2R8Y5D4;A0A1B0GTP9;P61764-2;A0A096LP52 A0A0D9SG72 STXBP1 Syntaxin-binding protein 1 0 3919220.0 2016400.0 758420.0 1144400.0 False True 2761917.5711610904 724910.4966404455 874116.2896578294 1.0 0.26246637633566244 0.3164889129150792 21.397238832637854 -10.370228036413444 8.91218240233205 1.0000017335450626 0.289477644625371 0.9956830515894681 0.022054608205068393 7.596866097589806e-07 5.366388766927012e-08 0.02135433472961484 0.0071180941904466135 4.263555921029734e-11 10.370228036413444 -0.7105240889196915 SSASFSTTAVSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSASFSTTAVSAR 13 0 A0A0D9SG72;P61764;A0A1B0GWF2;A0A1B0GVQ5;A0A2R8Y5D4;A0A1B0GTP9;P61764-2;A0A096LP52 A0A0D9SG72 STXBP1 Syntaxin-binding protein 1 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 SSASVVFTTYTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSASVVFTTYTQK 13 0 Q7L5D6;Q7L5D6-2 Q7L5D6 GET4 Golgi to ER traffic protein 4 homolog 0 3275700.0 1527400.0 1748300.0 0.0 False True 2002436.19136264 1487460.4548200248 0.0 1.0 0.7428253950043827 0.0 20.933324840486808 -7.347110435366753 0.7898279487626544 0.989410395109787 8.592981350259353e-23 0.9878463232935891 0.04674253088512143 0.10861501195448955 0.13786149214049162 0.04012495144233219 0.07141209992319321 4.496654963406909e-08 7.347110435366753 -0.989410395109787 down SSASVVFTTYTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSASVVFTTYTQK 13 0 Q7L5D6;Q7L5D6-2 Q7L5D6 GET4 Golgi to ER traffic protein 4 homolog 0 3135800.0 1527400.0 1608400.0 0.0 False True 2092121.0564329724 1537335.5697324618 0.0 1.0 0.7348215176198218 0.0 20.9965349020097 -7.361746148141656 0.7815392801548614 0.989635513728817 2.082367538203936e-19 0.9877278717096376 0.04685864150545358 0.10995583268109445 0.13811182362895683 0.04031685575456925 0.07188452419365984 4.3476427637610906e-08 7.361746148141656 -0.989635513728817 down SSAVQQLLEK(ub)NYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSAVQQLLEKNYR 13 1 Q9UNQ2;A0A494C0G7;A0A0C4DGB1 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 1 11064100.0 3967400.0 3383700.0 3713000.0 True False 5201299.8203562545 2878865.149559295 3328814.3776109684 1.0 0.5534895601080946 0.639996634030408 22.31044077143327 -10.094430610307375 5.307120306075367 1.0000063039959317 0.5967430970689076 0.9666370580527278 0.03531636504307762 2.6342633241249393e-06 4.495394376611825e-07 0.034195457722892626 0.011398307804852941 8.045802906394e-11 10.094430610307375 -0.4032632069270241 SSAVQQLLEK(ub)NYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSAVQQLLEKNYR 13 1 Q9UNQ2;A0A494C0G7;A0A0C4DGB1 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 1 12427400.0 2972700.0 4372500.0 5082200.0 True False 2878333.2656737096 6118462.052286272 3751019.357268105 1.0 2.125696188573275 1.303191469174829 21.456802212444465 -10.035514317362296 4.372961312944192 0.9999602003200614 1.7144438285598624 0.5014955913706861 0.335786145965071 61859394.262948304 121375849.73324744 36760.90589561217 0.12288515917328147 9.214795098698972e-11 10.035514317362296 0.714483628239801 SSAVQQLLEK(ub)NYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSAVQQLLEKNYR 13 1 Q9UNQ2;A0A494C0G7;A0A0C4DGB1 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 1 24249400.0 7820600.0 7164000.0 9264800.0 True False 11864421.962444527 5885528.227412516 7433608.219093913 1.0 0.4960653157855042 0.6265461766805118 23.500138477998426 -10.230502712620046 8.186897233955161 1.0000002199716587 0.5613057462330415 0.937779736227884 0.05326858839863997 2.1387886514085413e-07 2.008962412631734e-08 0.05157711506608054 0.017192362978659195 5.881624404463295e-11 10.230502712620046 -0.43869447373861714 SSAVQQLLEK(ub)NYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSAVQQLLEKNYR 13 1 Q9UNQ2;A0A494C0G7;A0A0C4DGB1 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 1 13374000.0 3967400.0 4646700.0 4759900.0 True False 5434254.994953634 4441393.429417951 3635709.653217666 1.0 0.8172957348417261 0.669035526782211 22.373650832956162 -6.97350304522931 0.1528670129709931 1.1655873632204126 0.316834866426874 0.9999984162268858 0.00017024925157221594 0.0751815796528658 0.0046854907105550025 0.007354345418825767 0.01828324785056556 1.0629111302234151e-07 6.97350304522931 -0.8487524967935386 SSAVQQLLEK(ub)NYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSAVQQLLEKNYR 13 1 Q9UNQ2;A0A494C0G7;A0A0C4DGB1 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 1 13826400.0 2972700.0 7322900.0 3530800.0 True False 2471931.7629391607 7283450.084218152 4269073.955425327 1.0 2.946460817979065 1.727019337438886 21.23720748787874 -10.074806752201269 4.837917227569822 0.9999640001912448 2.336740077717515 0.6157065256738317 0.49783489982645934 0.00023988111428649677 4.587370540966271e-05 0.48204254958168236 0.16067552300481414 8.417696201307639e-11 10.074806752201269 1.3367760775262703 SSAVQQLLEK(ub)NYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSAVQQLLEKNYR 13 1 Q9UNQ2;A0A494C0G7;A0A0C4DGB1 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 1 46496600.0 7820600.0 20554000.0 18122000.0 True False 10123920.867073016 19410151.83158189 14823981.947422355 1.0 1.9172563759078125 1.4642530440588282 23.271264800090876 -10.167674656013828 4.672841927834063 0.9999211043802523 1.6907547099024949 0.7561068852231637 0.1849378359170038 0.00017173413953093316 3.0589348189611524e-05 0.17908822481032052 0.059688429865354165 6.797126365691543e-11 10.167674656013828 0.6908336055222426 SSAYESLMEIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSAYESLMEIVK 12 0 Q14974;Q14974-2;J3KTM9;J3QKQ5 Q14974 KPNB1 Importin subunit beta-1 0 9298100.0 1961000.0 3456800.0 3880300.0 False True 2570889.990351012 2941058.9145008633 3478803.7784658847 1.0 1.1439847389577766 1.3531515512225059 21.293836447185107 -6.965784261424521 0.34432762728629185 0.9784205855990975 1.525712755504549 0.9999284089028327 0.001226767184431484 0.07769583665305038 0.013927189914136773 0.0029152682885048822 0.0180481920263615 1.0819712940177492e-07 6.965784261424521 0.5472921699054516 SSAYESLMEIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSAYESLMEIVK 12 0 Q14974;Q14974-2;J3KTM9;J3QKQ5 Q14974 KPNB1 Importin subunit beta-1 0 4156900.0 2427800.0 1729100.0 0.0 False True 2350730.8179105343 2419538.6471373793 0.0 1.0 1.0292708245038473 0.0 21.164677914823166 -7.002442314102143 1.118131375767104 1.0316167941146706 3.608130055115557e-20 0.9835083601199887 0.06144282501400592 0.09149397204934007 0.22370007416295073 0.04627969865906671 0.08476567289699334 9.94392146997288e-08 7.002442314102143 -1.0316167941146706 down SSAYESLMEIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSAYESLMEIVK 12 0 Q14974;Q14974-2;J3KTM9;J3QKQ5 Q14974 KPNB1 Importin subunit beta-1 0 11573900.0 1961000.0 4201900.0 5411000.0 False True 2686034.69403238 4016246.1641748543 4133033.243043084 1.0 1.495232423132074 1.5387117866442797 21.357046508708 -11.670258851683062 0.39719709553200677 7.454965270634162e-21 1.5418964545959448 0.9996830664660936 0.00435004259498195 4.459636926068958 0.20084175448076982 3.789717085232457 0.011201323659422252 2.13668818385628e-12 11.670258851683062 1.5418964545959448 SSAYESLMEIVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSAYESLMEIVK 12 0 Q14974;Q14974-2;J3KTM9;J3QKQ5 Q14974 KPNB1 Importin subunit beta-1 0 7944900.0 2427800.0 2228600.0 3288500.0 False True 2018823.2697761988 2216594.089457536 3976110.145693938 1.0 1.0979634139561218 1.9695186821056994 20.945083190257442 -6.928174097930326 0.7616245761434027 0.9858106062735135 2.140403329672299 0.9961672748244427 0.02697897501682001 0.09359653594111406 0.08240445027315003 0.02431753346233889 0.07966679611064116 1.1798475690905747e-07 6.928174097930326 1.1545927233987854 SSAYESLMEIVK(ub)NSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSAYESLMEIVKNSAK 16 1 Q14974;Q14974-2;J3KTM9;J3QKQ5 Q14974 KPNB1 Importin subunit beta-1 1 16896000.0 4401500.0 3710100.0 8784400.0 True False 4261776.79175929 5191562.277915905 6483502.1136488 1.0 1.2181685084855873 1.5213143321314975 22.023023604055616 -6.966497631378093 0.33134426012868384 0.9636413063748237 1.7857854024423867 0.9999407705438924 0.0016451482441029377 0.07745635875667269 0.01308761927006461 0.0044024419829399855 0.026412599709426714 1.0801955122019123e-07 6.966497631378093 0.822144096067563 SSAYESLMEIVK(ub)NSAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSAYESLMEIVKNSAK 16 1 Q14974;Q14974-2;J3KTM9;J3QKQ5 Q14974 KPNB1 Importin subunit beta-1 1 59930100.0 7203100.0 14773000.0 37954000.0 True False 10927629.31714755 12136642.728024187 30452375.264170878 1.0 1.1106382158277883 2.7867320880280273 23.381477115234095 -6.920304580686479 0.8224646163833796 0.963422492189525 3.0589200122647564 0.9942650962283912 0.06190439251188991 0.09799296372350504 0.10468810718967718 0.053423105603579636 0.160496528195688 1.2014215545795943e-07 6.920304580686479 2.0954975200752313 up SSAYESLMEIVK(ub)NSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSAYESLMEIVKNSAK 16 1 Q14974;Q14974-2;J3KTM9;J3QKQ5 Q14974 KPNB1 Importin subunit beta-1 1 17350600.0 4401500.0 5838900.0 7110200.0 True False 3660042.2695114617 5807444.686769091 8596909.946149634 1.0 1.58671519592703 2.3488553719072596 21.803428879489893 -6.9675377024596585 0.3114375228277785 0.8845614400607946 3.0752858527144613 0.9999563080028767 0.0036501525874147087 0.07711005989764053 0.011875870072215884 0.011981076512051514 0.06756993244618768 1.0776116987980617e-07 6.9675377024596585 2.1907244126536667 SSAYESLMEIVK(ub)NSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSAYESLMEIVKNSAK 16 1 Q14974;Q14974-2;J3KTM9;J3QKQ5 Q14974 KPNB1 Importin subunit beta-1 1 48299100.0 7203100.0 13120000.0 27976000.0 True False 9324554.944328262 12389860.466593094 22884655.05800067 1.0 1.3287347804336045 2.4542356385513555 23.152603437326544 -6.948448989386412 0.575618336328609 0.9863137882168586 2.8519083911864973 0.9990738890762143 0.01894956736489834 0.0841145691553396 0.03858627282987243 0.019949600938487872 0.09390976300098763 1.1260327207406545e-07 6.948448989386412 1.8655946029696389 up SSAYESLMEIVKNSAK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSAYESLMEIVKNSAK 16 1 Q14974;Q14974-2;J3KTM9;J3QKQ5 Q14974 KPNB1 Importin subunit beta-1 1 9181400.0 2072600.0 3610600.0 3498200.0 True False 2717198.6710869544 3071912.554008568 3136239.8211038723 1.0 1.1305439630513725 1.1542180755775542 21.37368862303766 -13.999999999999998 0.24012689873075635 0.13539224018865595 1.1646729207244448 0.9995251649966506 0.0014776459858333606 13.628201587520262 0.15509721018625258 5.650595605915015 0.011559647407603717 1.0000000000000041e-14 13.999999999999998 1.0292806805357888 SSCSLIAFNSDRPGVLGIVPLQGQGEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSCSLIAFNSDRPGVLGIVPLQGQGEDK 28 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2;I3L167;I3L426;I3L2Y6;I3L359;I3L1M1;I3NI06;I3L1G9 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 0 11917300.0 4719300.0 4402700.0 2795300.0 False True 6187048.001766203 3745834.321590181 2506069.170410968 1.0 0.6054315920162355 0.40505086912135896 22.560819796364687 -11.695909449056161 0.11244381245006485 2.196844623946548 4.9368294372662864e-21 0.9998143518343734 0.0033676446020091456 4.803457919095974 0.0766449881764339 1.6904373771938375 0.29241220867393536 2.0141441576666958e-12 11.695909449056161 -2.196844623946548 SSCSLIAFNSDRPGVLGIVPLQGQGEDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSCSLIAFNSDRPGVLGIVPLQGQGEDK 28 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2;I3L167;I3L426;I3L2Y6;I3L359;I3L1M1;I3NI06;I3L1G9 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 0 18746000.0 10251000.0 4990800.0 3504200.0 False True 9925587.616113702 6983652.466678176 2586344.8962533725 1.0 0.7036009087603601 0.26057347900033334 23.242721084754415 -7.152697111850109 0.3931079545626962 1.0301013184916321 8.779993349050609e-12 0.9997807558810792 0.004498946329485439 0.0822221055025406 0.02175525924355423 0.007698397655418245 0.04013068461266554 7.035628316438284e-08 7.152697111850109 -1.030101318482852 down SSCSLIAFNSDRPGVLGIVPLQGQGEDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSCSLIAFNSDRPGVLGIVPLQGQGEDK 28 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2;I3L167;I3L426;I3L2Y6;I3L359;I3L1M1;I3NI06;I3L1G9 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 0 57295300.0 8222300.0 30836000.0 18237000.0 False True 12473830.23064823 25333074.87723235 14632448.956438953 1.0 2.030897840423459 1.1730517961104674 23.57240119323531 -10.26108649259926 4.114027796086434 0.9994587654027459 1.6019748183017681 0.39634064591472773 0.3502141812241717 123833704.65831843 601.8113738227237 644144.9647422228 0.11988762936156351 5.48167782833795e-11 10.26108649259926 0.6025160528990222 SSCSLIAFNSDRPGVLGIVPLQGQGEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSCSLIAFNSDRPGVLGIVPLQGQGEDK 28 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2;I3L167;I3L426;I3L2Y6;I3L359;I3L1M1;I3NI06;I3L1G9 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 0 22545300.0 4719300.0 6469000.0 11357000.0 False True 6464152.744287102 6183178.189877704 8674710.504757045 1.0 0.956533428969834 1.3419717707666474 22.624029857887578 -6.8788739268866825 1.0860079595354366 0.97343799557944 1.368710109803842 0.9727680099340679 0.028444381111309997 0.12863469828839383 0.2783242992306333 0.020195328354309264 0.048702896178851915 1.3216792541542902e-07 6.8788739268866825 0.3952721142244019 SSDEAVILCK(ub)TAIGALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSDEAVILCKTAIGALK 17 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 16642600.0 3738700.0 7193400.0 5710500.0 True False 4901471.905622308 6120172.759653579 5119632.238983958 1.0 1.2486397713783368 1.0445091469587748 22.224783623055338 -10.166501549743371 3.921636957679902 0.9999227243085766 1.14657445890533 0.40738867336524676 0.08333597864721749 58852588.44273986 69045009.33512457 51961.19000642558 0.030497848786447547 6.815511426643735e-11 10.166501549743371 0.1466517345967533 SSDEAVILCK(ub)TAIGALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSDEAVILCKTAIGALK 17 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 16196800.0 3738700.0 8851800.0 3606300.0 True False 5120998.4245685255 8460698.207011823 2754566.2140798895 1.0 1.6521579398307835 0.5378963213237032 22.28799368457823 -6.748069881236714 1.6569307236273432 1.3843672489637617 0.5359991376637341 0.6406233117098086 0.2740199210041379 0.3034361781399776 1.6384264114252614 0.1306735160861742 0.31789266015358364 1.7862001387393634e-07 6.748069881236714 -0.8483681113000276 SSDEAVILCK(ub)TAIGALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSDEAVILCKTAIGALK 17 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 19219700.0 12101000.0 7118700.0 0.0 True False 15664983.046371214 6722538.087159778 0.0 1.0 0.4291442938214383 0.0 23.90103987254614 -8.168542167151507 0.5522743802906834 1.024471938177628 5.785955529077772e-16 0.9909609253562914 0.038943511196728585 0.12373357237180663 0.17179164708640546 0.05221543175311573 0.07358983579629114 6.783562533486754e-09 8.168542167151507 -1.0244719381776273 SSDFAK(ub)IINNTENLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSDFAKIINNTENLVR 16 1 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 1 19392300.0 4524400.0 10772000.0 4095900.0 True False 5931532.21435193 9164859.588927124 3672095.558647123 1.0 1.545108288673176 0.6190804375574535 22.499973394587116 -6.747198408667778 1.6602157486414528 1.3216139425983535 0.617630157286533 0.6367734825430276 0.22903445982187076 0.30498479088301034 1.6530527480319466 0.10901916276901658 0.26545202615040164 1.7897879974984877e-07 6.747198408667778 -0.7039837853118205 SSDFAK(ub)IINNTENLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSDFAKIINNTENLVR 16 1 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 1 63880000.0 39069000.0 17146000.0 7665000.0 True False 37828775.98028943 23992487.215208814 5657306.554928974 1.0 0.6342390572645022 0.14955034648429272 25.172980760299186 -7.492779905933457 0.4605024659380434 1.0214884008088618 1.0662875083691372e-25 0.9980199172866533 0.015499778844164933 0.11651967145141537 0.059943645125041266 0.019966163646465425 0.06725091068768903 3.2152895873682126e-08 7.492779905933457 -1.0214884008088618 down SSDFAK(ub)IINNTENLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSDFAKIINNTENLVR 16 1 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 1 46359000.0 10698000.0 12094000.0 23567000.0 True False 16229648.12856194 9935731.209146716 18908972.120216977 1.0 0.6121963415621563 1.165088236690714 23.952128385682034 -6.718218222662791 1.7661220515694789 0.7636087608858505 1.164117042578168 0.5038934911054785 0.16322641530942508 0.3588028121524365 2.1863354446110086 0.07341740305594253 0.18466497360032272 1.913294298499253e-07 6.718218222662791 0.40050828169231745 SSDFAK(ub)IINNTENLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSDFAKIINNTENLVR 16 1 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 1 27107100.0 4524400.0 15872000.0 6710700.0 True False 6197192.947312655 15170722.558314858 5125770.871204809 1.0 2.4479990678511108 0.827111712477428 22.563183456110007 -6.671143109280319 1.9329732523742806 1.9233568057019241 0.8335926868475261 0.2841308299777011 0.6149206964855176 0.45858539440488394 3.3043587109009156 0.2559837167143925 0.6829930447551223 2.1323421452182282e-07 6.671143109280319 -1.089764118854398 SSDFAK(ub)IINNTENLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSDFAKIINNTENLVR 16 1 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 1 60614400.0 39069000.0 14570000.0 6975400.0 True False 32487604.55016324 14491508.518081445 8433923.88939441 1.0 0.44606269741142335 0.2596043631463137 24.953386035733462 -13.999999999999988 0.15207105768214776 3.6874213309554666 0.05926870946759906 0.9995594744714879 0.006599485253583773 11.966107990346973 0.1229170834820128 9.497113903815885 0.18094390714037673 1.0000000000000286e-14 13.999999999999988 -3.6281526214878674 SSDFAK(ub)IINNTENLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSDFAKIINNTENLVR 16 1 Q9Y617;Q9Y617-2 Q9Y617 PSAT1 Phosphoserine aminotransferase 1 43569000.0 10698000.0 18519000.0 14352000.0 True False 13848771.889106601 17488401.370490655 11740083.26395575 1.0 1.262812436404341 0.8477346119904293 23.723254707774483 -6.735613118988213 1.7028622810757952 1.1571625295570924 0.8477215067494437 0.5850504151309877 0.11043989004727661 0.3258093100893578 1.8532815078537204 0.051345261361843426 0.12660339644627647 1.8381751092108857e-07 6.735613118988213 -0.30944102280764874 SSDIAK(ub)TFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSDIAKTFR 9 1 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 1 3096150.0 599260.0 871090.0 1625800.0 True False 580236.8193183403 1218920.77967434 1199954.2070454701 1.0 2.1007298039209625 2.068042163293207 19.146282320063364 -9.917660415465257 5.640669295981796 0.9999991487365409 2.0843859836089957 0.9993189722067006 0.013344673412326926 1.428643731618735e-07 2.7409384365142362e-08 0.012920934478967677 0.004306974822894923 1.2087586209900476e-10 9.917660415465257 1.0843868348724548 SSEDATDDISSGNIPVLQK(ub)DK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSEDATDDISSGNIPVLQKDK 21 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 95272000.0 38458500.0 52464000.0 4349500.0 True False 50419465.93264377 44636575.70307029 3899455.4633500953 1.0 0.885304413233989 0.07734027703822656 25.587477500765644 -7.053365025876898 0.8294334295875506 1.002943572368987 9.460878256075254e-23 0.9955605749230351 0.027357247791167803 0.07857509134237439 0.09286115103174228 0.02455472659256771 0.0589570950473375 8.843719799345274e-08 7.053365025876898 -1.002943572368987 down SSEDATDDISSGNIPVLQK(ub)DK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSEDATDDISSGNIPVLQKDK 21 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 282334800.0 51848600.0 66252700.0 164233500.0 True False 50202694.57348869 92707748.61326624 121215819.45061038 1.0 1.8466687774608785 2.4145281539254806 25.581261465508707 -8.207028171771801 0.14576295187519397 3.752535247734321e-18 3.5578737991728095 0.9999359392981433 0.004651847733193946 0.08705266917886498 0.029860390996746033 0.31934788122894164 0.3371528478087694 6.208287610647566e-09 8.207028171771801 3.5578737991728095 SSEDATDDISSGNIPVLQK(ub)DK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSEDATDDISSGNIPVLQKDK 21 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 172925700.0 2008000.0 129315700.0 41602000.0 True False 3046282.804463675 106238302.98682433 33379346.46519567 1.0 34.874734161632944 10.95740238440285 21.538618451286656 -9.842310291662406 6.855132643699692 1.0000014706408555 22.916068273018453 0.52819891525116 9.764209810513366 3.7787639726585544e-05 6.576230220318966e-06 9.454155918724855 3.151385165415794 1.4377709627275337e-10 9.842310291662406 21.916066802377596 SSEDATDDISSGNIPVLQK(ub)DK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSEDATDDISSGNIPVLQKDK 21 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 173598600.0 38458500.0 38213000.0 96927100.0 True False 52677646.75188391 36524623.3065074 74034915.25628567 1.0 0.6933609521044365 1.4054332306261945 25.650687562288535 -6.789673292107318 1.4975666868476347 0.8285460934626491 1.412945646197614 0.8002809132799857 0.13033081094913862 0.23584182974544218 1.0449035549875578 0.06850165812406112 0.16042232771389237 1.62303059987561e-07 6.789673292107318 0.5843995527349649 SSEDATDDISSGNIPVLQK(ub)DK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSEDATDDISSGNIPVLQKDK 21 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 207228700.0 51848600.0 63454300.0 91925800.0 True False 43114408.18243594 63112459.091207564 111147059.76312366 1.0 1.4638368413675336 2.5779562899903854 25.361666740942983 -6.9563131951749035 0.4846078496830824 0.974383808288567 3.114223319121569 0.9996080809517112 0.013109159390464932 0.08104538640149249 0.026204769156878114 0.01585852218998262 0.09189395440007123 1.1058260204758098e-07 6.9563131951749035 2.139839510833002 SSEDATDDISSGNIPVLQK(ub)DK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSEDATDDISSGNIPVLQKDK 21 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 106648700.0 2008000.0 85353700.0 19287000.0 True False 2599395.5835975013 80603691.56306759 15776963.901331825 1.0 31.008628341021495 6.069473996526871 21.309744773379105 -10.390149542220398 6.5670716863854235 0.9982664678771962 18.539051168773724 0.3973937941328183 10.18136712675436 0.25834265995696704 0.02399093278687301 9.852206844515383 3.286022110295273 4.072400271987475e-11 10.390149542220398 17.540784700896527 SSEDATDDISSGNIPVLQK(ub)DK(ub)DNTNVNADVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSEDATDDISSGNIPVLQKDKDNTNVNADVQK 32 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 34071800.0 5254400.0 6929400.0 21888000.0 True False 5087601.948113143 9696345.556343617 16154876.17407509 1.0 1.905877396705482 3.1753420056902257 22.278554368494433 -6.966362956771181 0.33383480238902197 0.8520936740944085 4.27092283588129 0.9999385459009213 0.00699423000114626 0.0775014610574436 0.013245557994112579 0.018278879219595177 0.11038995539031464 1.0805305324940286e-07 6.966362956771181 3.4188291617868813 SSEDATDDISSGNIPVLQK(ub)DK(ub)DNTNVNADVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSEDATDDISSGNIPVLQKDKDNTNVNADVQK 32 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 72657800.0 7804800.0 44333000.0 20520000.0 True False 11840452.207309803 36421429.774689995 16464213.005764484 1.0 3.076016788632863 1.3905054230614742 23.497220845244705 -6.594396336323029 2.2113282940122794 2.401142007793391 1.3955729904379592 0.004953090890195355 0.8985862292507021 0.6567724161262942 6.060705110808211 0.3383121155841893 1.0010136179515605 2.5445070803345693e-07 6.594396336323029 -1.0055690173554317 SSEDATDDISSGNIPVLQK(ub)DK(ub)DNTNVNADVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSEDATDDISSGNIPVLQKDKDNTNVNADVQK 32 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 2 27785100.0 5254400.0 9226700.0 13304000.0 True False 4369266.40938794 9176993.935743434 16085804.889254127 1.0 2.1003511976347937 3.6815802430109716 22.05895964392871 -6.965960237139192 0.34117081035285374 0.8308025160397402 5.003770901698455 0.9999315927841732 0.009102932513117019 0.07763660565872009 0.013719317929376695 0.022242247888037907 0.13674550765545382 1.081532969079779e-07 6.965960237139192 4.172968385658715 SSEDATDDISSGNIPVLQK(ub)DKDNTNVNADVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSEDATDDISSGNIPVLQKDKDNTNVNADVQK 32 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 59451300.0 1150300.0 52422000.0 5879000.0 True False 1508054.4395210443 44600841.93935559 5270697.475350084 1.0 29.575087457400244 3.495031304721366 20.524257078971477 -6.249916035507468 23.971741242766374 9.999999999999998 3.4950246837108545 0.07344186133045993 12.43897167460489 13.148080340757607 3733638.8232334447 5.00042227256829 19.465341150349744 5.624500561795538e-07 6.249916035507468 -6.504975316289144 SSEDATDDISSGNIPVLQK(ub)DKDNTNVNADVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSEDATDDISSGNIPVLQKDKDNTNVNADVQK 32 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 357357200.0 85213600.0 96181700.0 175961900.0 True False 82508540.91156647 134587554.39093927 129872199.64615218 1.0 1.6311954241827116 1.5740455256062593 26.29804013257586 -10.11421872610172 5.031273360702558 0.9999789410949498 1.6026204748961197 0.9932998454680316 0.023331348399692264 5.511533127091495e-06 9.702774542129943e-07 0.022591268637081 0.007530160315568553 7.687431764506254e-11 10.11421872610172 0.6026415338011699 SSEDATDDISSGNIPVLQK(ub)DKDNTNVNADVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSEDATDDISSGNIPVLQKDKDNTNVNADVQK 32 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 748798000.0 142201000.0 382192000.0 224405000.0 True False 215729313.2856271 313986851.5202742 180051253.38979444 1.0 1.4554667918705766 0.8346165416630486 27.684646982229097 -6.710081902771681 1.7948112659595006 1.2799896125621495 0.8360673252164181 0.46549299368849795 0.19192925849463527 0.3749348063014361 2.3544211297732525 0.08509471484351487 0.21616733363085802 1.9494769169388356e-07 6.710081902771681 -0.44392228734573136 SSEDATDDISSGNIPVLQK(ub)DKDNTNVNADVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSEDATDDISSGNIPVLQKDKDNTNVNADVQK 32 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 200041300.0 1150300.0 46991000.0 151900000.0 True False 1575596.9956886517 44914782.24154323 116024348.47869998 1.0 28.506516808831673 73.6383407661861 20.58746714049437 -7.085849210055727 0.4234151937393394 4.762781798119704e-15 98.35129569889678 0.9993888045879858 0.7402879374652154 0.10788179790506872 0.030482126773441004 0.9340511624111841 5.19183636017772 8.20636425317628e-08 7.085849210055727 98.35129569889678 SSEDATDDISSGNIPVLQK(ub)DKDNTNVNADVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSEDATDDISSGNIPVLQKDKDNTNVNADVQK 32 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 260902000.0 85213600.0 91730400.0 83958000.0 True False 70858884.00255418 91236230.1281411 101513229.62206836 1.0 1.2875764473633595 1.4326111827898562 26.078445408010136 -12.205229805227296 0.10547605145253716 7.671302327499189e-16 1.7468650547275921 0.9998219770214807 0.002398712592725134 6.175893435675828 0.07934202111009532 1.6022269512475709 0.24112989369723586 6.234048759387136e-13 12.205229805227296 1.7468650547275915 SSEDATDDISSGNIPVLQK(ub)DKDNTNVNADVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSEDATDDISSGNIPVLQKDKDNTNVNADVQK 32 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 697912900.0 142201000.0 424415000.0 131296900.0 True False 184081997.70077115 400795932.1592311 107402211.4199602 1.0 2.177268484508369 0.5834476633317756 27.455773304321546 -6.7088159107565 1.7993400511922697 1.7246252116480014 0.58730618386469 0.45952491525276884 0.49618637473938093 0.3774557295894411 2.3814377854602964 0.21950499650901495 0.5584658994381082 1.9551680390252273e-07 6.7088159107565 -1.1373190277833114 SSEDPNEDIVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSEDPNEDIVER 12 0 D6RD17;D6RHJ6;P01591;C9JA05 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 0 24010500.0 1042500.0 11373000.0 11595000.0 False True 1366727.595584361 9676192.73160679 10395260.627093777 1.0 7.079825389396353 7.605949174275036 20.382294295324986 -9.73364280862272 0.6408370113275532 1.6465436382659152e-14 7.536194542772144 0.9993556625959852 0.07609481060214111 1.0161614462098008 0.3037812286029836 2.4128558155137876 0.08660623399185735 1.846533501291742e-10 9.73364280862272 7.536194542772127 SSEDPNEDIVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSEDPNEDIVER 12 0 D6RD17;D6RHJ6;P01591;C9JA05 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 0 34746600.0 8524300.0 2615300.0 23607000.0 False True 8253700.762465916 3659602.9286093274 17423618.505180456 1.0 0.44338933939203856 2.1110068085355316 22.9766097037762 -6.81671160777041 1.3859764734602504 0.6989484183902215 2.144924169390489 0.8766550335627814 0.2434655490593548 0.1977979693890212 0.7474525870343189 0.13806838381982675 0.31854808344375335 1.525065133542075e-07 6.81671160777041 1.4459757510002673 up SSEDPNEDIVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSEDPNEDIVER 12 0 D6RD17;D6RHJ6;P01591;C9JA05 D6RD17;P01591 JCHAIN;IGJ Immunoglobulin J chain 0 27984500.0 1042500.0 11772000.0 15170000.0 False True 1427940.4225031917 11251874.11520176 11587158.43595705 1.0 7.879792418423962 8.11459515631938 20.445504356847877 -9.933361815884776 0.7953841323643415 3.977138874112709e-18 8.065494589032944 0.9998542331535171 0.03984100926266455 1.2218026398471253 0.4153892887237596 3.263705100499617 0.03389665713827681 1.1658379389419686e-10 9.933361815884776 8.065494589032944 SSEDVSTHAATK(ub)AR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSEDVSTHAATKAR 14 1 C9JK89;O14492;O14492-2 C9JK89 SH2B2 SH2B adapter protein 2 1 2362560.0 501580.0 689280.0 1171700.0 True False 485657.6174510106 964513.0985477152 864796.6197534611 1.0 1.9859939675403275 1.7806713797517961 18.88958006464612 -10.494114826352611 6.784120750734973 0.9996733082333317 1.8833326736460618 0.961056493626706 0.08382259545828438 0.00041432767455443806 3.0895902670976914e-05 0.08118876959353007 0.027053626353818062 3.205421707137964e-11 10.494114826352611 0.8836593654127302 SSEDVSTHAATK(ub)AR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSEDVSTHAATKAR 14 1 C9JK89;O14492;O14492-2 C9JK89 SH2B2 SH2B adapter protein 2 1 3853510.0 680550.0 477660.0 2695300.0 True False 1032444.1048693993 392417.8410253857 2162572.773608041 1.0 0.38008628183801313 2.0946148691328905 19.97763224752042 -6.808897150562547 1.4192051362423097 0.6617129299708477 2.1238476572786302 0.8569210069144266 0.26812415924549854 0.20830702905951845 0.8271297013317274 0.1485636471793337 0.343826656936305 1.5527546891352048e-07 6.808897150562547 1.4621347273077825 up SSEDVSTHAATK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSEDVSTHAATKAR 14 1 C9JK89;O14492;O14492-2 C9JK89 SH2B2 SH2B adapter protein 2 1 2050480.0 501580.0 951400.0 597500.0 True False 417085.9937615717 946274.6193618855 722434.4874721395 1.0 2.26877582444743 1.7320996108181976 18.669985340080395 -10.540872985651397 7.212466216065725 0.9995116266386538 2.000437717632814 0.822485412225063 0.2190971467467531 0.0017213043539249238 0.00010957326854214321 0.21222944418947948 0.07071330004597809 2.8782400656173024e-11 10.540872985651397 1.00092609099416 SSEDVSTHAATK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSEDVSTHAATKAR 14 1 C9JK89;O14492;O14492-2 C9JK89 SH2B2 SH2B adapter protein 2 1 3754100.0 680550.0 477950.0 2595600.0 True False 880985.3906460556 451351.6623481843 2123227.433105036 1.0 0.5123259331431061 2.410059753145286 19.74875856961287 -6.838528993922761 1.2893338322104675 0.7405093546553123 2.4706328275307525 0.9218745371610393 0.22491361526464088 0.17052513535571917 0.5513135988229348 0.136822344924613 0.31507724411916593 1.45034394469794e-07 6.838528993922761 1.7301234728754402 up SSEEDKK(ub)EEEVKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSEEDKKEEEVKK 13 3 O60763;O60763-2 O60763 USO1 General vesicular transport factor p115 1 13577000.0 4875300.0 6403100.0 2298600.0 True False 4720536.2701042965 8959891.221725391 1696527.7034781163 1.0 1.898066386751315 0.35939300249050576 22.170519333629993 -6.748486527548557 1.65535957426907 1.529027683388419 0.35666815265712554 0.6424714454536324 0.3773491154037416 0.3026908400764223 1.6314307060051636 0.1801088037752737 0.4379673951928937 1.7844873450949937e-07 6.748486527548557 -1.1723595307312935 SSEEDKK(ub)EEEVKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSEEDKKEEEVKK 13 3 O60763;O60763-2 O60763 USO1 General vesicular transport factor p115 1 12828770.0 4875300.0 7385800.0 567670.0 True False 4054027.962410366 7346011.229433482 686367.1723904765 1.0 1.8120277653600176 0.16930499215954825 21.95092460906427 -6.772288311784485 1.5656339304162434 1.4643910957586046 0.15924110241659067 0.7392654726606218 0.342450080076072 0.26274112020377355 1.2713193213346679 0.1723734464961107 0.40947522662017116 1.6893190838579286e-07 6.772288311784485 -1.3051499933420139 SSELQAIK(ub)TELTQIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSELQAIKTELTQIK 15 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 10277800.0 4678900.0 3143400.0 2455500.0 True False 4530370.880600377 4398576.012614445 1812330.8865790078 1.0 0.9709085919322202 0.40004029125730933 22.111197731229364 -6.917474804995364 0.8432446543179655 1.013778486578652 0.3131255956728466 0.9934501598197584 0.02235496501414356 0.09968062823571104 0.11348221107582979 0.019007809792198873 0.055632571024925574 1.2092753353747876e-07 6.917474804995364 -0.7006528909058055 down SSELQAIK(ub)TELTQIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSELQAIKTELTQIK 15 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 8092900.0 4678900.0 1765000.0 1649000.0 True False 3890712.66041513 1755491.594674932 1993798.2758854532 1.0 0.4512005249155627 0.5124506613327543 21.89160300666364 -10.165647032506643 5.5673831611011355 1.0000108315346465 0.4818255931557564 0.9896295844497927 0.025005263488567585 3.640874197953041e-06 5.456545936540374e-07 0.024211789727704987 0.008070414087391186 6.828934819326666e-11 10.165647032506643 -0.5181852383788901 SSESELCIETPK(ub)LTTSEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSESELCIETPKLTTSEEK 19 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 9970700.0 2792300.0 4591100.0 2587300.0 True False 3660732.340671661 3906125.775967633 2319591.0151340836 1.0 1.0670339736586554 0.6336412496928119 21.803700862250363 -6.86740534146582 1.1476595257113287 1.0373814481604664 0.6094726799252008 0.9620282210696663 0.03711747553055485 0.1393709516827285 0.3447013226534541 0.025136326740485115 0.05926074084133692 1.3570462789654735e-07 6.86740534146582 -0.4279087682352656 SSESELCIETPK(ub)LTTSEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSESELCIETPKLTTSEEK 19 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 27328300.0 7294200.0 11502000.0 8532100.0 True False 11065834.677449673 9449378.234463826 6845726.695247727 1.0 0.8539236767850945 0.6186362705380171 23.399608939534954 -6.964046678108185 0.3740520608287139 1.0172826829739934 0.4470348345756692 0.9998921250095634 0.0016317236899308736 0.07828596487514482 0.016009735408357845 0.0030834810518605856 0.019940336162949886 1.0863088605226249e-07 6.964046678108185 -0.5702478483983242 SSESELCIETPK(ub)LTTSEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSESELCIETPKLTTSEEK 19 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 10406500.0 2792300.0 4623400.0 2990800.0 True False 3824688.769070174 4419122.90046075 2284434.6374594844 1.0 1.1554202622178562 0.5972864134549847 21.866910923773254 -6.832397760919982 1.3171460999992015 1.0829176632894766 0.5815163292325526 0.9105915249484834 0.07032602513450206 0.17786820887643642 0.6026449528784456 0.04191099023400542 0.09644895039268533 1.470964660589139e-07 6.832397760919982 -0.501401334056924 SSESELCIETPK(ub)LTTSEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSESELCIETPKLTTSEEK 19 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 24764400.0 7294200.0 9157700.0 8312500.0 True False 9442485.690177739 8648065.944734734 6799710.29345263 1.0 0.9158675192624992 0.7201186760098375 23.170735261627403 -6.956982564073096 0.4760605961937271 1.0048772023866535 0.6230018733584323 0.9996413866451188 0.002220378583657272 0.0807971976258928 0.025251941527290423 0.0027383313420291837 0.01615030498057488 1.1041229470150226e-07 6.956982564073096 -0.3818753290282212 SSETQQPLSFKPNTLIGTLNVHTVFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSETQQPLSFKPNTLIGTLNVHTVFLK 27 1 O75128-3;O75128;O75128-7;O75128-2;A0A0J9YWK3;A0A3B3IU00;O75128-5;O75128-4;C9J9X1 O75128-3 COBL Protein cordon-bleu 0 13819400.0 5179500.0 3562200.0 5077700.0 False True 5015079.607614958 4984605.0366276 3747698.0422652187 1.0 0.9939234123141166 0.7472858529652587 22.257841171178534 -6.91219620290363 0.8806307839679877 1.0071162649972178 0.7138664634570082 0.9917246149369572 0.010709292364773566 0.10298398567785966 0.13101678119973748 0.008864174548414934 0.024858473483137355 1.224063074604894e-07 6.91219620290363 -0.29324980154020963 SSFADISNLLQIEPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSFADISNLLQIEPR 15 0 Q15785 Q15785 TOMM34 Mitochondrial import receptor subunit TOM34 0 4350050.0 1495000.0 2003100.0 851950.0 False True 1959959.4776005931 1704245.2880226462 763798.3864814603 1.0 0.8695308793368548 0.3897011112783372 20.902392396078426 -6.9468062815851255 0.5928701364591088 1.0055007331381305 0.22946753852951068 0.9989262291083122 0.0085987130120044 0.08479409058991687 0.04146924197142516 0.008888441671109654 0.04023279308590269 1.1302999760924198e-07 6.9468062815851255 -0.7760331946086199 down SSFADISNLLQIEPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSFADISNLLQIEPR 15 0 Q15785 Q15785 TOMM34 Mitochondrial import receptor subunit TOM34 0 11394100.0 5062300.0 1641300.0 4690500.0 False True 4901600.057462919 2296679.6492664265 3461917.3380162227 1.0 0.46855712876239725 0.7062831111129292 22.224821342665198 -10.351111154850235 5.872606727902608 1.0000638026985342 0.5874201199376644 0.800640832644585 0.09705122589344976 8.108485152443356e-05 8.9592181398549e-06 0.09398390647223472 0.03132314846786169 4.4554220017254565e-11 10.351111154850235 -0.4126436827608698 SSFADISNLLQIEPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSFADISNLLQIEPR 15 0 Q15785 Q15785 TOMM34 Mitochondrial import receptor subunit TOM34 0 7254500.0 1495000.0 1535500.0 4224000.0 False True 2047741.9008558942 1467656.5327805236 3226378.1960107177 1.0 0.7167194909510264 1.575578540763457 20.965602457601317 -6.8178339439066535 1.3813000096899004 0.8469728557452356 1.5934594959413821 0.8793126958292625 0.12413752169661534 0.1963105659170989 0.7365781921248769 0.07063406479256862 0.16289537677054525 1.5211290348430025e-07 6.8178339439066535 0.7464866401961465 SSFLASLNPK(ub)TWGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSFLASLNPKTWGR 14 1 Q14669-4;Q14669;Q14669-2;Q14669-3 Q14669-4 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 4334000.0 1063800.0 1937400.0 1332800.0 True False 1394652.1018538557 1648347.4719260528 1194894.6411203605 1.0 1.1819058457194953 0.8567689673518109 20.411473853725443 -6.75489838784363 1.631881175867459 1.106329926039182 0.8558798537379916 0.6697164807000267 0.07646378369363903 0.2915737249846088 1.5291148671546362 0.036993662206750266 0.08934784886005236 1.7583349645857197e-07 6.75489838784363 -0.2504500723011903 SSFLASLNPK(ub)TWGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSFLASLNPKTWGR 14 1 Q14669-4;Q14669;Q14669-2;Q14669-3 Q14669-4 TRIP12 E3 ubiquitin-protein ligase TRIP12 1 8072300.0 3488100.0 1997600.0 2586600.0 True False 3377372.1747894054 2795252.097346384 1909091.8636633125 1.0 0.8276411223529668 0.5652595464349004 21.687469737457764 -6.9650108069523355 0.35786646626170193 1.0231676825826508 0.3607711930114887 0.9999133674845615 0.001663696050391308 0.07795728692690006 0.014846988943131263 0.0035359121078529674 0.02243963950324789 1.0838999419982103e-07 6.9650108069523355 -0.662396489571162 SSFLIMWR ddPTM_RPMI8226_Bortezomib_1h_R1 2 SSFLIMWR 8 0 Q9BRG1;K7ENE3 Q9BRG1 VPS25 Vacuolar protein-sorting-associated protein 25 0 10297810.0 2331000.0 3488800.0 4478010.0 False True 3055963.573436108 2968284.6392358877 4014668.4813050544 1.0 0.9713089072911839 1.3137160783598556 21.543195916121824 -6.886548537966525 1.0425472784254894 0.980051264478781 1.3412532177860703 0.9785970314615583 0.022689674531754057 0.12198977003324003 0.23854509362161938 0.016652830574771346 0.04103340934347409 1.2985284285482814e-07 6.886548537966525 0.3612019533072893 SSFLIMWR ddPTM_RPMI8226_Bortezomib_2h_R1 2 SSFLIMWR 8 0 Q9BRG1;K7ENE3 Q9BRG1 VPS25 Vacuolar protein-sorting-associated protein 25 0 11427830.0 3937630.0 2781500.0 4708700.0 False True 3812632.0909996913 3892167.455330877 3475350.2120279255 1.0 1.0208610121388164 0.9115356869161407 21.86235589081598 -6.857292356677423 1.1993435380538728 1.0112466117663694 0.9065090141192618 0.9502633666995562 0.010568997685526686 0.1496171197444824 0.4104968988017377 0.006880343153162071 0.016014926202329006 1.38901726315303e-07 6.857292356677423 -0.10473759764710766 SSFLIMWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSFLIMWR 8 0 Q9BRG1;K7ENE3 Q9BRG1 VPS25 Vacuolar protein-sorting-associated protein 25 0 38122700.0 9519700.0 10370000.0 18233000.0 False True 14442080.883293254 8519392.478820186 14629239.558192201 1.0 0.5899006208084255 1.012959259570098 23.783775291735825 -10.95707464698663 11.658542337026931 1.0627287626778557 0.8014299401892617 0.22704799134748244 0.17271296604042177 0.0969176589464337 0.000356838728802506 0.05755403245359026 0.05574287009572003 1.1038888660301452e-11 10.95707464698663 -0.26129882248859393 SSFLIMWR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SSFLIMWR 8 0 Q9BRG1;K7ENE3 Q9BRG1 VPS25 Vacuolar protein-sorting-associated protein 25 0 11531010.0 2331000.0 3576110.0 5623900.0 False True 3192833.6929064137 3418105.635585648 4295650.647856221 1.0 1.0705554890565474 1.3454038202490655 21.606405977644716 -6.945483826646518 0.6064094411054733 0.9969427070303954 1.4332417256693857 0.9987974505197644 0.005167175500345638 0.08535163632532675 0.043870732887695815 0.005270326792219391 0.023147020606357517 1.1337470586522448e-07 6.945483826646518 0.43629901863899023 SSFLIMWR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SSFLIMWR 8 0 Q9BRG1;K7ENE3 Q9BRG1 VPS25 Vacuolar protein-sorting-associated protein 25 0 9000980.0 3937630.0 2387850.0 2675500.0 False True 3274313.811586147 2374986.178098884 3234934.6798857027 1.0 0.7253385945155911 0.9879733177800181 21.642761166250256 -10.630165720283602 8.782577980237301 1.000080962004228 0.8566559562117135 0.2842755950993151 0.10722017678915205 0.00017006929521003425 7.161675039585556e-06 0.10387384803049528 0.03460516325681675 2.3433344632859057e-11 10.630165720283602 -0.14342500579251438 SSFLIMWR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SSFLIMWR 8 0 Q9BRG1;K7ENE3 Q9BRG1 VPS25 Vacuolar protein-sorting-associated protein 25 0 53685000.0 15738900.0 20991900.0 16954200.0 False True 20374316.310100935 19823682.31163687 13868709.564782508 1.0 0.9729741116176213 0.6806957030458414 24.280248312631276 -6.9249496327295414 0.7871416019221887 1.0053731003474822 0.6277434358834773 0.9954491238759878 0.009752922523647314 0.09534629766523722 0.09115742913170358 0.008631534468311785 0.02721736873265154 1.1886400718881494e-07 6.9249496327295414 -0.3776296644640049 SSFLPSYIIDVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSFLPSYIIDVR 12 0 Q10570 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 0 9829800.0 2396600.0 4507600.0 2925600.0 False True 3141965.808707416 3835083.650487185 2622886.9763368294 1.0 1.2206000586826606 0.8347916992183526 21.58323605044112 -6.75162519547388 1.643756703979849 1.1294634926203648 0.8339265894280286 0.6559242504814171 0.0927064553584465 0.2972397362634125 1.5806158308148661 0.04454283475121128 0.10795720236730096 1.7716372559177652e-07 6.75162519547388 -0.2955369031923363 SSFLPSYIIDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSFLPSYIIDVR 12 0 Q10570 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 0 13025900.0 2396600.0 5942800.0 4686500.0 False True 3282687.785679761 5680227.445788402 3579645.221497216 1.0 1.7303587232899678 1.0904616750678782 21.64644611196401 -10.247979738897412 4.506536393812456 0.9998324241351565 1.4104101991825728 0.3542022629159838 0.2612368760219486 0.0004400137957751424 7.342672777507259e-05 0.2530440156448881 0.08431383918561185 5.649633313825195e-11 10.247979738897412 0.4105777750474163 SSFSHYSGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSFSHYSGLK 10 0 Q8NC51;Q8NC51-3 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 21578400.0 6602800.0 7584900.0 7390700.0 False True 8656334.741606154 6453262.485708631 6625981.260600413 1.0 0.7454959493065133 0.7654488254426012 23.04532485877513 -10.633624893269216 6.516831804089672 1.001001666063256 0.7554723873745572 0.995031178808448 0.008145727572395083 0.0001190059173295928 6.69049259643215e-06 0.007917587741541122 0.0026290222692190624 2.3247438459909372e-11 10.633624893269216 -0.24552927868869867 SSFSHYSGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSFSHYSGLK 10 0 Q8NC51;Q8NC51-3 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 30848300.0 6382400.0 20278000.0 4187900.0 False True 9682567.41594072 16659232.467262847 3360159.7293782206 1.0 1.7205387529588712 0.34703189609052265 23.206958210535685 -6.764126853734277 1.5966598912499914 1.4163619887515462 0.34091170556089534 0.7077210909831958 0.30326972399902297 0.2760219317811665 1.3876689183960287 0.1497934509813848 0.3585657357333891 1.7213657052265107e-07 6.764126853734277 -1.075450283190651 SSFSHYSGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSFSHYSGLK 10 0 Q8NC51;Q8NC51-3 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 17016300.0 6602800.0 4471700.0 5941800.0 False True 9044033.593960738 4274125.508065561 4538469.215212233 1.0 0.4725906271422587 0.5018191460769065 23.10853492029802 -10.727208661075196 6.833172476849866 1.007013157211143 0.48720488660973943 0.9975693059059187 0.011932492887860613 0.0012767573577084931 5.0970164781004225e-05 0.011570607481496572 0.0038511955194518786 1.8740938648075618e-11 10.727208661075196 -0.5198082706014036 SSFSHYSGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSFSHYSGLK 10 0 Q8NC51;Q8NC51-3 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 15642500.0 6382400.0 4807300.0 4452800.0 False True 8262142.615912699 4539769.529043669 3642436.0895862672 1.0 0.5494663721127466 0.4408585349968443 22.978084532628134 -13.999999999999938 0.19983704582952783 3.502903945820534 0.370210298270239 0.999486923127917 0.005483351963058218 12.527648796430743 0.1417467741707989 12.255001737967541 0.06923976732502625 1.0000000000001431e-14 13.999999999999938 -3.1326936475502953 SSFSITR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSFSITR 7 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 18498800.0 5149000.0 5089300.0 8260500.0 False True 6750388.862986924 4329996.277936024 7405782.700311164 1.0 0.6414439769059584 1.0970897900294059 22.686539181790415 -6.696873180270919 1.8420398940402072 0.7766737915033533 1.0956574558296228 0.40277004234248337 0.15143896513572933 0.4020481482147878 2.649950468457782 0.06564315338735598 0.1694702922333926 2.0096795799332915e-07 6.696873180270919 0.31898366432626957 SSFSITR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSFSITR 7 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 14963200.0 3559200.0 1969300.0 9434700.0 False True 3446215.1442075777 2755651.759763831 6963469.0350669855 1.0 0.7996168679124834 2.0206135553583278 21.716581339892414 -6.864787551861358 1.1613993849120665 0.8895713269894602 2.0853555230597993 0.9591935401904434 0.10800219273915303 0.1419458608286707 0.36115245337154595 0.07237923522906509 0.1699625909543888 1.3652508265514633e-07 6.864787551861358 1.1957841960703393 up SSFSITR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSFSITR 7 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 14872600.0 5149000.0 3689500.0 6034100.0 False True 7052724.446492976 3526485.690455061 4608969.856190406 1.0 0.5000175063139798 0.6535020460755777 22.749749243313307 -10.87285195992473 11.052690202151139 1.016644051025727 0.5767597761947865 0.9102231156608027 0.06265980097030516 0.022647723093305757 0.0002605345367016415 0.05346640573372325 0.020223363802888614 1.3401334273844122e-11 10.87285195992473 -0.4398842748309406 SSFSITR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSFSITR 7 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 8477100.0 3559200.0 2650400.0 2267500.0 False True 2959632.499294601 2636121.769136788 2741623.766264565 1.0 0.8906922632337229 0.9263392556062294 21.49698661532669 -9.838244459797387 5.3631473663207405 1.0000000537873501 0.9085157601160554 0.8977697311984572 0.014552823701424232 9.358484228755494e-09 2.0358094944886975e-09 0.014090719145483566 0.004696903652245091 1.4512944692304048e-10 9.838244459797387 -0.09148429367129474 SSFSITR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSFSITR 7 0 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 0 10530600.0 3361100.0 4391700.0 2777800.0 False True 4351010.207186041 4147298.034385433 2272268.9026349112 1.0 0.9531804884152739 0.5222393868169 22.052918970675016 -6.9275860107075555 0.766357281708753 1.0071738207181578 0.438975705196516 0.996041922492919 0.013528502233306648 0.09391117454415246 0.08396687893120273 0.01215246733945948 0.03952310117299022 1.1814463075085246e-07 6.9275860107075555 -0.5681981155216418 SSFTVDCSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSFTVDCSK 9 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 2541230.0 619430.0 1921800.0 0.0 False True 812078.728568653 1635074.9311177274 0.0 1.0 2.013443861532569 0.0 19.6312600735341 -6.775714876474915 1.5908084279539298 1.5810972002758645 1.7058253937139132e-10 0.729770239063446 0.4273008094206936 0.26250712577170116 1.3179332405074542 0.21295169176662385 0.49652373330787347 1.6760428725433605e-07 6.775714876474915 -1.581097200105282 SSFTVDCSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSFTVDCSK 9 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 3064130.0 619430.0 1356000.0 1088700.0 False True 848450.0104663328 1296087.4363076456 831571.4824803204 1.0 1.5275943430011607 0.9801066323557054 19.694470135056992 -6.6546054698196535 1.9923422160478936 1.3411036397119631 0.982415531283144 0.21288238990619457 0.2249303780030356 0.49731201889940685 3.788962456234551 0.09140236791510001 0.249177336127778 2.2151060853090814e-07 6.6546054698196535 -0.35868810842881915 SSFYVNGLTLGGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSFYVNGLTLGGQK 14 0 P07737;K7EJ44;I3L3D5 P07737 PFN1 Profilin-1 0 1695540000.0 591050000.0 261090000.0 843400000.0 False True 572287441.274413 365344598.566363 622488238.542348 1.0 0.6383935278271806 1.0877195507840327 29.092164706698824 -6.692486107482067 1.8574372650980902 0.773826940764059 1.0862206840698039 0.38213425350328467 0.15285769313607167 0.41135693746941504 2.753458252184983 0.06578574297474778 0.17078488982254467 2.0300834585612896e-07 6.692486107482067 0.3123937433057449 SSFYVNGLTLGGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSFYVNGLTLGGQK 14 0 P07737;K7EJ44;I3L3D5 P07737 PFN1 Profilin-1 0 1303020000.0 359210000.0 577820000.0 365990000.0 False True 544947831.7686236 474703506.47173405 293651916.0808846 1.0 0.8710989911292752 0.5388624359286646 29.021542885408525 -6.954804834741867 0.5033442505741651 1.0064651006710703 0.38908504842532754 0.999526369277601 0.004227762044683912 0.08161190726067034 0.028407777470320115 0.004927439495243867 0.02741008611653698 1.1096733733724508e-07 6.954804834741867 -0.6173800522457428 SSFYVNGLTLGGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSFYVNGLTLGGQK 14 0 P07737;K7EJ44;I3L3D5 P07737 PFN1 Profilin-1 0 1053350000.0 570300000.0 483050000.0 0.0 False True 781155321.778005 461707253.7672628 0.0 1.0 0.5910569139007601 0.0 29.541034195660284 -7.674114804458507 0.6546825198508472 0.9992236453408024 4.9453082540298275e-15 0.9873657401021648 0.046140967557747166 0.12065431285001278 0.1499255633981196 0.0426698268669942 0.07773260057065313 2.1178012267721644e-08 7.674114804458507 -0.9992236453407974 down SSFYVNGLTLGGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSFYVNGLTLGGQK 14 0 P07737;K7EJ44;I3L3D5 P07737 PFN1 Profilin-1 0 1380670000.0 591050000.0 414000000.0 375620000.0 False True 491484262.95461774 411769699.82743376 454160405.3293471 1.0 0.8378085136480868 0.9240588958008671 28.8725699821331 -10.133852913801775 4.3671958073139745 1.0000177763189921 0.8809337047171207 0.7175890863991907 0.03521157110549805 49184898.99293852 0.40225867165263884 9714.021795289666 0.01205385735621858 7.347626743332418e-11 10.133852913801775 -0.1190840716018714 SSFYVNGLTLGGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSFYVNGLTLGGQK 14 0 P07737;K7EJ44;I3L3D5 P07737 PFN1 Profilin-1 0 1271700000.0 359210000.0 555030000.0 357460000.0 False True 465004426.0876783 524142092.5894181 292405947.8493324 1.0 1.127176566896998 0.6288240099336133 28.792669207500975 -6.839038477358201 1.2869953336102482 1.067663386339257 0.6127567191765586 0.9227640711703926 0.05875757448921912 0.16992657620417795 0.547175202837908 0.035806408669086874 0.08246450435760452 1.4486435018236838e-07 6.839038477358201 -0.45490666716269845 SSFYVNGLTLGGQK(ub)CSVIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSFYVNGLTLGGQKCSVIR 19 1 P07737;K7EJ44;I3L3D5 P07737 PFN1 Profilin-1 1 19558400.0 11383000.0 8175400.0 0.0 True False 17268843.20876993 6716435.995308247 0.0 1.0 0.3889337527772171 0.0 24.041668108232567 -8.32619534406024 0.531509882023612 1.0358244494389635 1.2520654655311502e-17 0.9922133294578871 0.036319743260630664 0.158478818203653 0.17790061236049873 0.06224805405811899 0.0705321382617079 4.7185075679026304e-09 8.32619534406024 -1.0358244494389635 SSFYVNGLTLGGQK(ub)CSVIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSFYVNGLTLGGQKCSVIR 19 1 P07737;K7EJ44;I3L3D5 P07737 PFN1 Profilin-1 1 10978100.0 5666000.0 3211100.0 2101000.0 True False 4711530.046359636 3193801.166946557 2540309.386073584 1.0 0.6778692135083055 0.5391686694296589 22.167764213416365 -13.999999999966622 0.11490899073244343 2.5430141739006573 0.30180888540559764 0.9997182426422156 0.003240252320615158 11.98607602203333 0.10363251080831548 4.254793300030991 0.21064592251771883 1.0000000000768551e-14 13.999999999966622 -2.2412052884950597 SSGCDVNLPGVNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSGCDVNLPGVNVK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 10894900.0 1249400.0 5501900.0 4143600.0 False True 1637975.4992068103 4681037.966238228 3714860.0202178285 1.0 2.8578192827090643 2.2679582338177524 20.64348234667111 -10.082176252964128 5.149313970044974 0.9999706393663118 2.562888758266883 0.9034788360972527 0.2408097648332074 8.117101324728692e-05 1.4467442799975542e-05 0.23316740434595415 0.07772101739852123 8.276062219511733e-11 10.082176252964128 1.5629181189005714 SSGCDVNLPGVNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSGCDVNLPGVNVK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 6877100.0 2618900.0 1733000.0 2525200.0 False True 2535764.4530133856 2424995.937475609 1863774.365623829 1.0 0.9563175059867471 0.7349950676250727 21.273989309181605 -6.939510515963483 0.6641027481243125 1.0025064344476518 0.676161377094005 0.9980990618635761 0.005057889105654126 0.0879907105960453 0.0556321668257441 0.004905397133763688 0.019090240287848215 1.1494484104531309e-07 6.939510515963483 -0.3263450573536467 SSGCDVNLPGVNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSGCDVNLPGVNVK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 15020100.0 1249400.0 5428000.0 8342700.0 False True 1711336.9437654547 5188173.012004347 6372326.083299859 1.0 3.0316490454467777 3.7235952315029386 20.706692408194 -9.526920206427313 0.31602951188579304 2.562812332842418e-21 3.95677785113812 0.9986295004537891 0.042790675732928204 0.8976117960955348 0.12837473370205996 1.1739218624417307 0.22816416790244043 2.9722120705294733e-10 9.526920206427313 3.95677785113812 SSGEIVYCGQVFEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSGEIVYCGQVFEK 14 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 62927000.0 13529000.0 24249000.0 25149000.0 False True 17736650.01502235 20631143.72186167 22546822.72624243 1.0 1.1631928072317932 1.271199618143563 24.08023021257096 -8.842341958203411 0.04236815637940526 4.497823983312448e-17 2.2343327442577294 0.9999989303825476 0.00011514873079676898 0.35841916842992516 0.012528662051414263 0.34600971581475504 0.3097033848028481 1.4376661316159145e-09 8.842341958203411 2.2343327442577294 SSGEIVYCGQVFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSGEIVYCGQVFEK 14 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 17512700.0 8955500.0 3304600.0 5252600.0 False True 8671212.554492868 4624144.013261344 3876786.4853776866 1.0 0.5332753619175681 0.44708700899841086 23.047802318715515 -13.999999999999995 0.23755708906874845 4.0531080730126865 0.40808507518977233 0.999520993661144 0.005316004960844155 13.538395764617873 0.15427506466004373 19.580558461952045 0.042727888828975304 1.0000000000000123e-14 13.999999999999995 -3.645022997822914 SSGEIVYCGQVFEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSGEIVYCGQVFEK 14 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 69620100.0 8918500.0 51244000.0 9457600.0 False True 13530016.529685898 42099107.82880054 7588301.214586657 1.0 3.111534101708734 0.5608493676217867 23.689660266074494 -6.686855850472333 1.877477693815227 2.3276358598472955 0.5699448311446054 0.3558820854947137 0.8936004257765788 0.423415358706409 2.8911547050242365 0.3811049350963491 0.9964153401384097 2.0565730933650976e-07 6.686855850472333 -1.7576910287026901 SSGEIVYCGQVFEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSGEIVYCGQVFEK 14 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 50311000.0 13529000.0 15720000.0 21062000.0 False True 18531036.90747785 15025438.420911634 16087589.385506095 1.0 0.8108255623217935 0.8681429682444944 24.14344027409385 -9.945267013002715 6.119729738314505 1.000000056342587 0.839484265283121 0.9127159734551344 0.023399732981847592 1.7991873434895566e-08 3.0893900661753298e-09 0.02265670213871616 0.007552231345354366 1.1343132026166376e-10 9.945267013002715 -0.160515791059466 SSGEIVYCGQVFEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSGEIVYCGQVFEK 14 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 17518100.0 8955500.0 1347700.0 7214900.0 False True 7446895.045918421 1340439.6726024956 8723502.232071534 1.0 0.179999807213233 1.1714281157826725 22.82820759414979 -6.687081865171143 1.8770272765295122 0.4845073586268803 1.1678642983390506 0.3567171481737037 0.34701107945325305 0.4229582567634413 2.886921891758696 0.1480312397388157 0.38687307436433277 2.0555030939997806e-07 6.687081865171143 0.6833569397121703 SSGEIVYCGQVFEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSGEIVYCGQVFEK 14 0 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 31639800.0 8918500.0 13301000.0 9420300.0 False True 11545174.059917487 12560787.657481298 7705902.060440512 1.0 1.0879686691853192 0.6674565511484013 23.460786588166943 -6.8521098232163 1.2249801253910082 1.0470392694208825 0.6499603033638908 0.9433031530932618 0.04312038064003574 0.15515386494933242 0.44698189645197134 0.02752996651997107 0.06379336407670688 1.4056920115797536e-07 6.8521098232163 -0.3970789660569918 SSGEIVYCGQVFEK(ub)SPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSGEIVYCGQVFEKSPLR 18 1 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 1 36400800.0 4885200.0 8442600.0 23073000.0 True False 6404544.5083440915 7182996.988997039 20685627.291844297 1.0 1.1215468921542742 3.229835824373498 22.610664538966763 -6.918749647538989 0.8339459656164493 0.9513524104281438 3.560229211253013 0.993826514132392 0.0804343969048333 0.09891316208795034 0.10946712749900638 0.06884744148298394 0.2038295375802869 1.20573079305019e-07 6.918749647538989 2.608876800824869 up SSGEIVYCGQVFEK(ub)SPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSGEIVYCGQVFEKSPLR 18 1 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 1 22147700.0 7591100.0 5222900.0 9333700.0 True False 7350124.685658066 7308431.207063689 6888923.965002035 1.0 0.994327514106566 0.9372526670797913 22.80933729299492 -6.926095114739638 0.7781711000662936 1.001004994683852 0.9266211585183732 0.9957136008706489 0.0018552407353369495 0.09471676200641158 0.08798755274252615 0.001652481391254995 0.00527950790836604 1.1855090816483695e-07 6.926095114739638 -0.07438383616547872 SSGEIVYCGQVFEK(ub)SPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSGEIVYCGQVFEKSPLR 18 1 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 1 59103800.0 8423800.0 17742000.0 32938000.0 True False 12779520.462271469 14575801.48112128 26427789.862761743 1.0 1.1405593444725026 2.067979775984833 23.60733036593598 -6.9338591471663795 0.7144068071260312 0.9877143082291198 2.278542407145509 0.997243827872961 0.02487456916356755 0.09068286111479341 0.06822308982302075 0.023206666918670054 0.08220764228715509 1.1645036465563508e-07 6.9338591471663795 1.2908280989163894 up SSGEIVYCGQVFEK(ub)SPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSGEIVYCGQVFEKSPLR 18 1 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 1 48515800.0 4885200.0 6003600.0 37627000.0 True False 6691390.457566029 5738341.100749696 28740277.55239 1.0 0.8575708049231068 4.295112911830313 22.673874600489654 -6.8972343817094695 0.9785950495440899 0.8460335283121113 4.636331782493747 0.9851391590227014 0.19358118711911682 0.11346943263968308 0.18912687629629257 0.14910148972550935 0.38282060265034906 1.2669679192174707e-07 6.8972343817094695 3.790298254181636 up SSGEIVYCGQVFEK(ub)SPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSGEIVYCGQVFEKSPLR 18 1 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 1 36742500.0 7591100.0 3747400.0 25404000.0 True False 6312335.992749855 3727212.012399342 30715858.945175257 1.0 0.5904647687766141 4.866005070144317 22.589742568429195 -6.883409673701092 1.0606394933563603 0.7326807687671887 5.189491314111784 0.9763317156132326 0.2963439672443914 0.12465090801487265 0.25441918647893674 0.21453193209683863 0.5235747946509014 1.3079475427808516e-07 6.883409673701092 4.456810545344595 up SSGEIVYCGQVFEK(ub)SPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSGEIVYCGQVFEKSPLR 18 1 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 1 67002800.0 8423800.0 0.0 58579000.0 True False 10904775.157922627 0.0 47918223.07129764 1.0 0.0 4.3942421899899236 23.37845668802843 -6.846883285212774 1.2500713737933495 0.46748884494941995 4.559588224951037 0.9356437521530124 0.47708316323378774 0.16091704893990613 0.4854745217221702 0.2988657866115705 0.6903416194280272 1.4227110832778027e-07 6.846883285212774 4.092099380001617 SSGFGLEFNSFQHQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSGFGLEFNSFQHQLR 16 0 Q15650 Q15650 TRIP4 Activating signal cointegrator 1 0 9824200.0 2742200.0 3625300.0 3456700.0 False True 3595050.7555025765 3084419.371308717 3099033.8430077657 1.0 0.8579626773245723 0.8620278415442095 21.77758070833227 -10.059005520715774 4.686362811610285 1.0000054488042471 0.8599952594306502 0.999368079119307 0.0016595963559402488 9.448494265043566e-08 1.8970229137303492e-08 0.0016069597844162976 0.000535632418851231 8.729602713183301e-11 10.059005520715774 -0.14001018937359688 SSGFGLEFNSFQHQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSGFGLEFNSFQHQLR 16 0 Q15650 Q15650 TRIP4 Activating signal cointegrator 1 0 8589100.0 2639300.0 2457700.0 3492100.0 False True 2555516.86617978 3439072.4267361863 2577414.2492455943 1.0 1.3457443667265736 1.0085686709235258 21.285183682350276 -10.332950009716376 7.10382462409215 0.9999967659183391 1.1771565188250497 0.2690478085213015 0.1376514013975578 7.050870857910034e-06 6.620514019398173e-07 0.1332828288593203 0.04442679876623779 4.64568747205098e-11 10.332950009716376 0.1771597529067106 SSGFGLEFNSFQHQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSGFGLEFNSFQHQLR 16 0 Q15650 Q15650 TRIP4 Activating signal cointegrator 1 0 9201900.0 2742200.0 3226200.0 3233500.0 False True 3756065.445168588 3083655.8163832757 2469813.896022885 1.0 0.8209803214024851 0.6575534777222258 21.84079076985516 -6.972213280370672 0.19832554575443634 1.099402323424796 0.3746274432720894 0.9999948880675353 0.0003161457155895929 0.07559092458915695 0.006390516429565278 0.005379782836517979 0.017423969412949908 1.0660724485232716e-07 6.972213280370672 -0.7247748801527066 SSGFGLEFNSFQHQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSGFGLEFNSFQHQLR 16 0 Q15650 Q15650 TRIP4 Activating signal cointegrator 1 0 6462200.0 2639300.0 2076900.0 1746000.0 False True 2194694.890814861 2065711.3274676264 2111080.527408127 1.0 0.9412293873344078 0.9619016001920483 21.065588957784552 -9.957920406484915 6.191856536574731 1.0000000170901742 0.9515654938916362 0.8797987484912604 0.00843939555925175 1.9931333554361218e-09 3.3430697540197377e-10 0.008171412535577505 0.0027238032044177144 1.1017412080779297e-10 9.957920406484915 -0.048434523198537915 SSGGFVWACK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSGGFVWACK 10 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 66181000.0 21740000.0 17684000.0 26757000.0 False True 28501350.530459452 15045616.13169212 23988442.31126759 1.0 0.5278913402932552 0.8416598464564369 24.76452694690763 -10.135423332002887 5.3986726134948375 1.0000067772461099 0.6847755933747385 0.5736944756649394 0.12809545624290009 1.0449180918400369e-05 1.673409972462648e-06 0.12403055822211746 0.041342630729410974 7.321105546271556e-11 10.135423332002887 -0.3152311838713714 SSGGFVWACK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSGGFVWACK 10 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 13189800.0 8356200.0 1746100.0 3087500.0 False True 8090937.004952622 2443326.83579121 2278791.126985415 1.0 0.30198317380244116 0.2816473698399236 22.947875359015182 SSGGFVWACK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSGGFVWACK 10 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 53733000.0 21740000.0 15145000.0 16848000.0 False True 29777865.501409452 14475843.822182363 12868849.395451847 1.0 0.48612765147646964 0.4321615797090203 24.82773700843052 -13.999999999992886 0.31837931054097734 6.218512803942846 0.42125284512894134 0.9996902425721635 0.004504025107147887 17.88845512497296 0.17987350027917248 62.12657615708328 0.018081940290080464 1.0000000000163813e-14 13.999999999992886 -5.797259958813905 SSGGFVWACK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSGGFVWACK 10 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 15101300.0 8356200.0 1422700.0 5322400.0 False True 6948550.542426825 1415035.632716159 6435289.232002869 1.0 0.20364472044581963 0.9261340466202185 22.728280634449458 -10.843040939601222 9.822446143419429 1.0124990684886446 0.5648893835337205 0.32595827310268954 0.2949550322890867 0.07690882411383683 0.0012289724021723582 0.27205851383991064 0.09519632732797528 1.4353541205704194e-11 10.843040939601222 -0.44760968495492404 SSGGK(ub)GGSYSQAASSDSAQGSDVSLTA ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSGGKGGSYSQAASSDSAQGSDVSLTA 27 1 D9J307 D9J307 HLA-B 1 12041700.0 3297700.0 3161600.0 5582400.0 True False 4323316.634972226 2689901.6038202774 5004786.798161981 1.0 0.6221847324484847 1.1576267066994812 22.043707070831122 -6.717078694386806 1.7695275260012098 0.7694357631482759 1.1566765730565036 0.49887022263437664 0.15904491899528886 0.3610052492016289 2.207465670024466 0.07140609277024891 0.1798951400251016 1.918321108389536e-07 6.717078694386806 0.38724080990822773 SSGGK(ub)GGSYSQAASSDSAQGSDVSLTA ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSGGKGGSYSQAASSDSAQGSDVSLTA 27 1 D9J307 D9J307 HLA-B 1 20508000.0 1758600.0 1752400.0 16997000.0 True False 1702774.205608973 2452142.458645274 12544975.80092991 1.0 1.4400866835825128 7.367374816700008 20.699455710127328 -6.921795845261147 0.8112948246951717 0.8774897957386032 8.363838284344991 0.9946654223642298 0.21206230231284473 0.09712667208197387 0.10022270664420985 0.18447262907890416 0.5624383855076972 1.197303231722066e-07 6.921795845261147 7.486348488606389 up SSGGK(ub)GGSYSQAASSDSAQGSDVSLTA ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSGGKGGSYSQAASSDSAQGSDVSLTA 27 1 D9J307 D9J307 HLA-B 1 30845200.0 2825100.0 6642100.0 21378000.0 True False 4285883.24247526 5456765.360035829 17152628.929689754 1.0 1.2731950571953379 4.002122306949142 22.031161117472948 -6.926214153441779 0.7772416770089995 0.9521634425498774 4.511912415113341 0.995740395759233 0.08846221790138403 0.0946517392094354 0.0876643840083793 0.07884714841682768 0.2522556921952826 1.185184182001619e-07 6.926214153441779 3.5597489725634635 up SSGGK(ub)GGSYSQAASSDSAQGSDVSLTA ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSGGKGGSYSQAASSDSAQGSDVSLTA 27 1 D9J307 D9J307 HLA-B 1 13443800.0 3297700.0 2450700.0 7695400.0 True False 4516948.806991628 2342419.9706188412 5877905.011737906 1.0 0.5185845735052588 1.3012998957702822 22.106917132354013 -6.7403040462161625 1.6856541959008922 0.7136581066675621 1.3017822780324264 0.6062662340303295 0.20226885122089883 0.3172716653260694 1.7702421387471448 0.09492422669125924 0.23285142060029385 1.818427345918234e-07 6.7403040462161625 0.5881241713648643 SSGGK(ub)GGSYSQAASSDSAQGSDVSLTA ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSGGKGGSYSQAASSDSAQGSDVSLTA 27 1 D9J307 D9J307 HLA-B 1 19886700.0 1758600.0 2081100.0 16047000.0 True False 1462353.8191895636 2069888.701233995 19402353.507055108 1.0 1.41544999169977 13.26789266212461 20.479860985561604 -6.9143350520543425 0.8656974327807662 0.6814027308817537 14.950593288982201 0.9924571596982122 0.49397812933102614 0.10162049949504401 0.12373574630201255 0.41330393016795053 1.1782588286055697 1.2180495283510602e-07 6.9143350520543425 14.269190558100448 up SSGGK(ub)GGSYSQAASSDSAQGSDVSLTA ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSGGKGGSYSQAASSDSAQGSDVSLTA 27 1 D9J307 D9J307 HLA-B 1 34611700.0 2825100.0 7153600.0 24633000.0 True False 3657147.641046462 6755495.871480204 20150046.75592401 1.0 1.8472034860334967 5.509771202498744 21.802287439565397 -6.9430939015002 0.6301224550563834 0.9600472791873788 6.594361602280384 0.9985417177698575 0.07473454402464359 0.08638308244773081 0.04839177874678082 0.07458314033316583 0.3111893466637719 1.140003273742343e-07 6.9430939015002 5.6343143230930055 SSGGSGGGPLSHFYSGSPTSYFTSGLQAGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSGGSGGGPLSHFYSGSPTSYFTSGLQAGLK 31 0 A0A087WZ13;E9PAU2;Q8IY67-2;K7EQG2 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 0 27080900.0 8568100.0 6520800.0 11992000.0 False True 8296110.355440825 9124589.445522783 8850935.447711453 1.0 1.0998635570871618 1.0668777376986984 22.9840036544334 -10.06540019510005 4.2025110901353635 0.999990275079661 1.0833706473138445 0.8949300241409689 0.01346640444621843 9341669.288940597 0.3612460658105098 890.2139242831762 0.0046099084168267765 8.602007262811219e-11 10.06540019510005 0.08338037223418349 SSGGSGGGPLSHFYSGSPTSYFTSGLQAGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSGGSGGGPLSHFYSGSPTSYFTSGLQAGLK 31 0 A0A087WZ13;E9PAU2;Q8IY67-2;K7EQG2 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 0 24764000.0 7185500.0 9999100.0 7579400.0 False True 9301771.397380402 9442641.295084683 6200026.971211415 1.0 1.0151444162284995 0.6665426085355622 23.14907405359454 -6.896745453526923 0.9816327706471292 1.015816006197457 0.6322785162127077 0.9848757940414622 0.019785317564101387 0.1138400418983014 0.1912466585989398 0.015204733476383488 0.03895133284287527 1.268395073303877e-07 6.896745453526923 -0.38353748998474935 SSGLTAVWVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSGLTAVWVAR 11 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 28541000.0 8289300.0 8668700.0 11583000.0 False True 10867352.573695397 7375363.750327951 10384502.271981629 1.0 0.6786716176099907 0.955568727669468 23.37349718838597 -10.142578144429699 7.1050860809654806 1.0000001479482887 0.8171201734573074 0.3677337526533555 0.11304277181616576 2.6492705355028875e-07 3.19076414564608e-08 0.10945328123559739 0.0364843977210946 7.201481602974391e-11 10.142578144429699 -0.18287997449098137 SSGLTAVWVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSGLTAVWVAR 11 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 15695300.0 3916500.0 2210200.0 9568600.0 False True 3792172.851283714 3092744.3860407392 7062296.608153089 1.0 0.8155599724294723 1.8623351005116717 21.85459329463799 -6.861392266477629 1.1785655720154633 0.8995249589665678 1.914417487676984 0.9553175155038571 0.09644064866339358 0.1453808773469597 0.3829118705883602 0.06378180854140245 0.14913844122511524 1.3759660978019558e-07 6.861392266477629 1.014892528710416 SSGLTAVWVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSGLTAVWVAR 11 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 18794100.0 3802500.0 7550900.0 7440700.0 False True 5768670.499986609 6203382.899549019 5970042.383625343 1.0 1.075357467472517 1.0349078498484532 22.45980742994774 -10.133746411227097 4.260503810320381 0.9999887608825857 1.055132658665924 0.7123965485133275 0.016513487263204677 11533220.982468551 0.038708139318044524 1271.625863724902 0.005653005920517637 7.349428831910931e-11 10.133746411227097 0.05514389778333828 SSGLTAVWVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSGLTAVWVAR 11 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 22288600.0 8289300.0 5107000.0 8892300.0 False True 11354078.219909558 4881355.853409398 6792121.882667162 1.0 0.429920928750505 0.5982098899721395 23.43670724990886 -10.872635096631068 11.13174450286446 1.018568817659895 0.5140654093613831 0.9174705364051168 0.06870368072267163 0.02680152621562772 0.0003066516055000034 0.056311295381482634 0.022174017605171552 1.3408027850084021e-11 10.872635096631068 -0.5045034082985119 SSGLTAVWVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSGLTAVWVAR 11 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 12393800.0 3916500.0 2609200.0 5868100.0 False True 3256743.2803684305 2595143.7217143527 7095092.578971148 1.0 0.7968524069298971 2.1785851595181582 21.634998570072266 -6.8695334338875895 1.1366176120302438 0.8854342189693734 2.258772315766393 0.964212402950344 0.11523565226886671 0.1373000137220161 0.33181889429218814 0.07870720969746346 0.1861854932170597 1.3504128631681793e-07 6.8695334338875895 1.3733380967970197 up SSGLTAVWVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSGLTAVWVAR 11 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89;A0A3B3ITV3;A0A3B3ISK1 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 19402700.0 3802500.0 9292800.0 6307400.0 False True 4922411.208480821 8775647.510972274 5159517.919389239 1.0 1.7827944759780967 1.0481688141981935 22.23093375204019 -10.244044443144864 4.2990710471519895 0.999766316519926 1.415481645099266 0.29897927715048955 0.29990967059076035 0.0006721304573242333 0.00011818871840722782 0.2905480277749398 0.09679542995839549 5.7010592800542e-11 10.244044443144864 0.41571532857934 SSGPTSLFAVTVAPPGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSGPTSLFAVTVAPPGAR 18 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;A0A1W2PP35;A0A1W2PP22 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 471700000.0 139710000.0 166120000.0 165870000.0 False True 183161162.95356455 141335543.53068826 148707363.53739047 1.0 0.771645807722459 0.8118935321189847 27.448538389421806 -10.25515594251982 5.486864160208208 1.0000170484862487 0.7917696699207203 0.972744461347571 0.016431064679978267 3.4269793099933077e-06 4.652353584308656e-07 0.015910611752257154 0.00530310332216251 5.557046840490926e-11 10.25515594251982 -0.20824737856552844 SSGPTSLFAVTVAPPGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSGPTSLFAVTVAPPGAR 18 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;A0A1W2PP35;A0A1W2PP22 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 362157000.0 126040000.0 85037000.0 151080000.0 False True 122038929.19080782 118992717.56209682 111507615.69715205 1.0 0.9750390170668554 0.9137052941755162 26.862766185508892 -6.955831059117173 0.49067628368597765 1.0013340525782766 0.8848064625232333 0.9995829381046831 0.0007404376735473878 0.08122540237130377 0.026900756237858984 0.0008843651874499189 0.005058622207298597 1.1070543452077837e-07 6.955831059117173 -0.11652759005504332 SSGPTSLFAVTVAPPGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSGPTSLFAVTVAPPGAR 18 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;A0A1W2PP35;A0A1W2PP22 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 535700000.0 121430000.0 249260000.0 165010000.0 False True 184218187.7221236 204777605.5227312 132395701.1735479 1.0 1.1116036264107627 0.7186896300014349 27.456840263748425 -6.830808216876553 1.3241966745793365 1.0596036181384136 0.7079343116015531 0.9074887560629022 0.05028275978562053 0.17982480104586976 0.6163875604380533 0.02981077304526712 0.06860524605394307 1.4763583447048984e-07 6.830808216876553 -0.35166930653686057 SSGPTSLFAVTVAPPGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSGPTSLFAVTVAPPGAR 18 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;A0A1W2PP35;A0A1W2PP22 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 438450000.0 139710000.0 128110000.0 170630000.0 False True 191364562.52078742 122449676.59688224 130330708.23515832 1.0 0.6398764483031223 0.6810597872372575 27.511748450944697 -10.304938901655952 8.589772982809547 1.0000003634657981 0.6604681179786185 0.9890861639009358 0.016813027715454537 1.1701753711413239e-07 9.488776235663943e-09 0.016279161550113462 0.005426381361773261 4.955198976901314e-11 10.304938901655952 -0.33953224548717964 SSGPTSLFAVTVAPPGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSGPTSLFAVTVAPPGAR 18 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;A0A1W2PP35;A0A1W2PP22 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 268824000.0 126040000.0 69572000.0 73212000.0 False True 104807844.51873781 69197201.82703917 88520290.70595868 1.0 0.6602292237263587 0.8445960425236376 26.64317146094317 -10.176650661989532 4.981474160118114 1.0000195990462364 0.7524126331245794 0.7062736866952775 0.0752674385937012 1.6384608100573078e-05 2.7080882768625004e-06 0.07288314923764969 0.024292461348550325 6.658085042355427e-11 10.176650661989532 -0.24760696592165699 SSGPTSLFAVTVAPPGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSGPTSLFAVTVAPPGAR 18 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;A0A1W2PP35;A0A1W2PP22 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 411890000.0 121430000.0 170570000.0 119890000.0 False True 157193528.74314976 161077629.55691952 98071250.17528239 1.0 1.0247090376100423 0.6238885974468347 27.227966585840875 -6.892223635310134 1.0091061758524689 1.0204025172551479 0.5878701824875785 0.9822847997228265 0.024410551727705513 0.11735867162839954 0.2114432573959221 0.018375394836737047 0.046193873608881664 1.2816704301870017e-07 6.892223635310134 -0.43253233476756936 SSGPYGGGGQYFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSGPYGGGGQYFAK 14 0 P09651;F8W6I7;P09651-3;Q32P51;P09651-2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 89007000.0 12175000.0 36340000.0 40492000.0 False True 15961542.902867716 30918213.652210567 36302276.26669088 1.0 1.9370441717545785 2.2743588441045173 23.928096778850026 -10.26537001139692 0.2324683290541077 6.369142756018712e-16 2.4874892102963475 0.9992121411203112 0.01513237668958797 1.8308497875845042 0.11153794873576904 1.2825697600296984 0.16775513375287676 5.4278768870349875e-11 10.26537001139692 2.487489210296347 SSGPYGGGGQYFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSGPYGGGGQYFAK 14 0 P09651;F8W6I7;P09651-3;Q32P51;P09651-2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 94270000.0 32843000.0 16589000.0 44838000.0 False True 31800416.942349315 23213074.21049215 33093582.6888331 1.0 0.72996131631151 1.0406650563364672 24.922542345341178 -6.676977773898043 1.9132551808181184 0.8286769861052711 1.0394389712642877 0.31012339783027953 0.11452593966930145 0.44524051326062825 3.1485926634671317 0.04808548771741922 0.12728608531038108 2.1038861086238156e-07 6.676977773898043 0.21076198515901667 SSGPYGGGGQYFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSGPYGGGGQYFAK 14 0 P09651;F8W6I7;P09651-3;Q32P51;P09651-2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 138148000.0 32896000.0 96035000.0 9217000.0 False True 49905637.01973953 78896803.92512016 7395255.910045392 1.0 1.5809196843617797 0.14818478135286187 25.57269944652976 -6.7966432630602815 1.4696831084393114 1.3218938706955399 0.13003010397251524 0.8221410922190496 0.2481420563216357 0.22558237122115135 0.9622802606704987 0.1328520062531868 0.309603671871158 1.5971905682909278e-07 6.7966432630602815 -1.1918637667230247 down SSGPYGGGGQYFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSGPYGGGGQYFAK 14 0 P09651;F8W6I7;P09651-3;Q32P51;P09651-2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 82417000.0 12175000.0 37608000.0 32634000.0 False True 16676426.517003698 35946354.206974916 24926521.31832714 1.0 2.1555189998482662 1.4947159868399529 23.991306840372918 -10.061684325708375 4.842080062239558 0.9999767830133738 1.8251174933535788 0.6752049908532285 0.26977170042915355 187072032.8762621 2.8404272020236006 49246.230379261404 0.09235002855817787 8.675922707438657e-11 10.061684325708375 0.825140710340205 SSGPYGGGGQYFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSGPYGGGGQYFAK 14 0 P09651;F8W6I7;P09651-3;Q32P51;P09651-2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 61069900.0 32843000.0 18639000.0 9587900.0 False True 27310409.6915972 18538588.00744817 11592685.560559211 1.0 0.6788103223933721 0.42447863988382495 24.702947620775454 -7.471520947443695 0.18447042526032967 1.2232021534564206 6.294913722291808e-15 0.9999684869908827 0.0013219080638651886 0.1274026156337404 0.016043113395335675 0.032047484992847715 0.0635304966372825 3.376595618239025e-08 7.471520947443695 -1.2232021534564144 down SSGPYGGGGQYFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSGPYGGGGQYFAK 14 0 P09651;F8W6I7;P09651-3;Q32P51;P09651-2;H0YH80 P09651;P09651-2 HNRNPA1;HNRNPA1L2 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed;Heterogeneous nuclear ribonucleoprotein A1-like 2 0 60868000.0 32896000.0 16872000.0 11100000.0 False True 42584520.47710326 15933058.368320016 9079913.89561795 1.0 0.37415140970970573 0.213220996594291 25.34382576862221 -13.999999999999952 0.1906887578302402 4.362945796141994 0.09856461736598296 0.9994890436632605 0.007671449489124007 12.362011912790981 0.13848056861054422 15.450533408684572 0.11007078803658896 1.0000000000001104e-14 13.999999999999952 -4.264381178776011 SSGPYGGGGQYFAK(ub)PR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSGPYGGGGQYFAKPR 16 1 P09651;F8W6I7;P09651-3;P09651-2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 15196000.0 5054300.0 6918100.0 3223600.0 True False 6626236.24591082 5885946.446542583 2890052.794954675 1.0 0.8882789909844999 0.43615299661828133 22.659758210220925 -6.944607039895897 0.615214615127833 1.0049688845740792 0.2957062580918925 0.9987071573498337 0.008765092443648691 0.08572637494225605 0.045501434467862506 0.00886607233965175 0.038195681619157595 1.1360382655475496e-07 6.944607039895897 -0.7092626264821866 down SSGPYGGGGQYFAK(ub)PR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSGPYGGGGQYFAKPR 16 1 P09651;F8W6I7;P09651-3;P09651-2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 1 35671000.0 12221000.0 10522000.0 12928000.0 True False 11833051.044437196 14723489.471505111 9541768.968313342 1.0 1.2442682294036693 0.8063659095596479 23.49631877163038 -6.7553138499629375 1.6299830104654642 1.1427108047654069 0.8051208257753695 0.6715550415958452 0.10268299445211096 0.29088482538301835 1.5220056845705439 0.049730234446040085 0.12007513180889806 1.7566536808238424e-07 6.7553138499629375 -0.3375899789900374 SSGPYGGGGQYFAKPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSGPYGGGGQYFAKPR 16 1 P09651;F8W6I7;P09651-3;P09651-2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 126905000.0 35365000.0 47145000.0 44395000.0 False True 46363857.47514712 40111149.769770704 39801431.26691051 1.0 0.8651383201078962 0.858458148963245 25.466497267845565 SSGPYGGGGQYFAKPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSGPYGGGGQYFAKPR 16 1 P09651;F8W6I7;P09651-3;P09651-2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 627251000.0 94649000.0 461320000.0 71282000.0 False True 143589452.76876622 378993841.69038826 57193081.45598948 1.0 2.6394267432769793 0.39830976686074676 27.097374540313922 -6.710588587244949 1.7929802347159156 2.0072567518397832 0.4034439082059139 0.4679888512367848 0.6907792416926525 0.37387462415237355 2.3432819378849308 0.3065437549441953 0.7782467435985865 1.9472038194384957e-07 6.710588587244949 -1.6038128436338694 SSGPYGGGGQYFAKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSGPYGGGGQYFAKPR 16 1 P09651;F8W6I7;P09651-3;P09651-2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 141879000.0 35365000.0 48120000.0 58394000.0 False True 48440396.203189746 45993899.288439475 44602539.862180404 1.0 0.9494946964412077 0.9207715741029256 25.529707329368456 -13.999999999898339 0.06485732807967662 1.3058807855138876 0.8045091535314374 0.9999407505163602 0.0002520211935673754 12.413696266570996 0.06696597236750941 0.5944400639908365 0.10801398101349693 1.000000000234083e-14 13.999999999898339 -0.5013716319824503 SSGPYGGGGQYFAKPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSGPYGGGGQYFAKPR 16 1 P09651;F8W6I7;P09651-3;P09651-2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 90510000.0 42583000.0 31505000.0 16422000.0 False True 35409651.24675831 31335276.3117471 19855764.273251005 1.0 0.8849360332125775 0.5607444178109143 25.077639298760754 -6.952852684363585 0.5265966770287688 1.0052411716522203 0.425807710635541 0.9994065482958855 0.004530545015327339 0.08236009216865711 0.03137529718280979 0.005080258650133212 0.026797592186607745 1.1146725739750788e-07 6.952852684363585 -0.5794334610166793 SSGPYGGGGQYFAKPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSGPYGGGGQYFAKPR 16 1 P09651;F8W6I7;P09651-3;P09651-2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 319955000.0 94649000.0 88766000.0 136540000.0 False True 122524996.31071717 83826094.06841493 111691121.01870938 1.0 0.6841550425827903 0.9115782442912005 26.86850086240637 -10.178993446275184 6.039713556231652 1.0000022232768864 0.7978666447734527 0.5129751304605569 0.09284513330928248 2.779611422404586e-06 3.7772241021681595e-07 0.08989790229404267 0.02996563792360406 6.622264969613153e-11 10.178993446275184 -0.20213557850343367 SSGSGAGK(ub)GAVSAEQVIAGFNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSGSGAGKGAVSAEQVIAGFNR 22 1 Q9UHV9 Q9UHV9 PFDN2 Prefoldin subunit 2 1 28910400.0 11207000.0 13406000.0 4297400.0 True False 9319117.054280346 13333779.217117334 5195966.471067394 1.0 1.4307985552121616 0.5575599534594154 23.151761841612128 -6.772567888231064 1.5645696082807548 1.246290297587915 0.5521612388014708 0.7402618221234394 0.18169294271572894 0.26232105676326645 1.2675981591670331 0.09151528610538663 0.21734014443241872 1.6882319370954024e-07 6.772567888231064 -0.6941290587864443 SSGSHLVFVPSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSGSHLVFVPSLR 13 0 Q14181;A0A3B3ITS5;Q14181-2;H0YDR7 Q14181 POLA2 DNA polymerase alpha subunit B 0 10286900.0 2936600.0 3281600.0 4068700.0 False True 3849911.0380748534 2791998.071576614 3647709.9537262977 1.0 0.7252110617529364 0.9474790242296959 21.87639367840156 -9.954780392773623 6.001152683498071 1.0000000873788382 0.8363450433878663 0.41956369170931873 0.09074051570614726 1.0606696700632779e-07 1.854349998858323e-08 0.08785917367018944 0.0292863755129969 1.1097358272274359e-10 9.954780392773623 -0.16365504399097186 SSGSHLVFVPSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSGSHLVFVPSLR 13 0 Q14181;A0A3B3ITS5;Q14181-2;H0YDR7 Q14181 POLA2 DNA polymerase alpha subunit B 0 9036600.0 2936600.0 2419000.0 3681000.0 False True 4022340.378631052 2312120.581436724 2811623.6125746793 1.0 0.5748197227962151 0.6990019113030849 21.93960373992445 -10.518486501241231 9.284744318220858 1.0000122824099569 0.6369108170496521 0.9193449164965053 0.050697166163990774 1.2890050166438212e-05 6.684200976054504e-07 0.04908897711813505 0.016362440021087197 3.030494490277645e-11 10.518486501241231 -0.36310146536030474 SSGSPYGGGYGSGGGSGGYGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSGSPYGGGYGSGGGSGGYGSR 22 0 P51991;H7C1J8;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 41368700.0 8998700.0 17700000.0 14670000.0 False True 11797382.843534758 15059228.994059615 13152089.124576574 1.0 1.2764889631696936 1.1148310857593493 23.491963508761888 -10.183387638576525 3.7700173292856833 0.9998379265093947 1.1956600244936644 0.6613855353428032 0.06599655256551364 46684748.51390153 120053479.77112593 102768.61975480206 0.024152275487199205 6.55559871484571e-11 10.183387638576525 0.19582209798426964 SSGSPYGGGYGSGGGSGGYGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSGSPYGGGYGSGGGSGGYGSR 22 0 P51991;H7C1J8;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 43210600.0 11253000.0 8154600.0 23803000.0 False True 10895779.674580775 11410774.305677218 17568280.22530652 1.0 1.0472655143989278 1.6123931237607807 23.377266099986617 -6.923445647791255 0.7987506355408914 0.9890105643838488 1.711163172406135 0.995085892138031 0.019503013134425994 0.0961864642662034 0.09541616130776372 0.017118138898552834 0.05309565129499866 1.192763531569771e-07 6.923445647791255 0.7221526080222861 SSGSPYGGGYGSGGGSGGYGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSGSPYGGGYGSGGGSGGYGSR 22 0 P51991;H7C1J8;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 152128000.0 21919000.0 113660000.0 16549000.0 False True 33252725.493545473 93376484.97036675 13278082.896315642 1.0 2.80808515947036 0.3993081078088768 24.98696925730284 -6.7058247210189785 1.8098911755031106 2.116270072831312 0.4055878835213276 0.4453323577320879 0.7624333448309099 0.3835367772474976 2.4463019328940283 0.33555625549745033 0.8568776483415214 1.9686806786138144e-07 6.7058247210189785 -1.7106821893099846 SSGSPYGGGYGSGGGSGGYGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSGSPYGGGYGSGGGSGGYGSR 22 0 P51991;H7C1J8;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 45970700.0 8998700.0 16481000.0 20491000.0 False True 12325762.570723707 15752814.924621152 15651447.82539197 1.0 1.2780397832777843 1.269815781018488 23.55517357028478 -10.084884252169486 4.861012888707349 0.9999903156471666 1.273927782148984 0.9993244409154658 0.0033574348715816023 3.5497695889793295e-07 6.683147617134862e-08 0.003250938070558652 0.0010836074440950178 8.224618226298282e-11 10.084884252169486 0.2739374665018175 SSGSPYGGGYGSGGGSGGYGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSGSPYGGGYGSGGGSGGYGSR 22 0 P51991;H7C1J8;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 24875000.0 11253000.0 8762400.0 4859600.0 False True 9357368.092425872 8715195.211999774 5875719.8917483045 1.0 0.9313724891354983 0.6279244156809739 23.157671375420893 -6.942580203290236 0.6351110517538033 1.0033134020113785 0.5394855709743384 0.9984826415021599 0.006297521696619243 0.08660914623756824 0.049396553947676974 0.006257377475314412 0.02583495357850926 1.1413525059943507e-07 6.942580203290236 -0.4638278310370402 SSGSPYGGGYGSGGGSGGYGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSGSPYGGGYGSGGGSGGYGSR 22 0 P51991;H7C1J8;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 61969000.0 21919000.0 20280000.0 19770000.0 False True 28374577.588084485 19151400.17244726 16172062.857330319 1.0 0.6749492609359453 0.5699490259238803 24.758095579395288 -13.999999999999998 0.15805565782978676 2.594427331126363 0.46448173420357214 0.9995416175773967 0.003919469305523629 11.997287723310148 0.12556694411608402 5.865301173384847 0.09589484289427501 1.0000000000000041e-14 13.999999999999998 -2.1299455969227905 SSHSTWPVDVSQIK(ub)QGFIVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSHSTWPVDVSQIKQGFIVVK 21 1 Q6P2E9 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 26809900.0 3586300.0 6772600.0 16451000.0 True False 5440679.293649442 5563976.615434682 13199452.639270544 1.0 1.0226621190352383 2.426067027085648 22.375355359108102 -6.910408821953631 0.8929468602556226 0.9571076357547045 2.6090280713033374 0.9910749177474167 0.06301109622198935 0.10414827140354987 0.1373056984428784 0.05169253303620303 0.14310207422861274 1.229111205503257e-07 6.910408821953631 1.6519204355486328 up SSHSTWPVDVSQIK(ub)QGFIVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSHSTWPVDVSQIKQGFIVVK 21 1 Q6P2E9 Q6P2E9 EDC4 Enhancer of mRNA-decapping protein 4 1 20866900.0 3586300.0 3775600.0 13505000.0 True False 4642536.046541694 3565484.5409808643 11047228.573001822 1.0 0.7680036310405939 2.379567646271933 22.14648168120055 -6.870381420226828 1.1321502292046257 0.8684981334374223 2.474605181360329 0.9650586047739715 0.13296991141416478 0.1364857969048058 0.3267464786108832 0.0911324422720336 0.21589204889113456 1.3477786726230367e-07 6.870381420226828 1.6061070479229067 up SSHYDELLAAEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSHYDELLAAEAR 13 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 34412700.0 2512100.0 14160700.0 17739900.0 False True 3293387.4272110034 12047978.757976271 15904345.321136752 1.0 3.6582330576816076 4.829175331675237 21.651140806868884 -9.013688098137129 0.3135055103986847 1.4414317005451052e-18 5.299831051509706 0.9984867804997711 0.06232103935173221 0.47396870400972185 0.10987313873029769 0.9487331138424221 0.3802688801063504 9.689735043841725e-10 9.013688098137129 5.299831051509706 SSHYDELLAAEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSHYDELLAAEAR 13 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 84104300.0 3550200.0 75093000.0 5461100.0 False True 5385912.9543859195 61692067.44571311 4381711.191314839 1.0 11.454338005124146 0.8135503169888166 22.36075948291969 -6.650283268250022 2.007942426417578 7.78268481222272 0.8588868381113445 0.19494161356175266 4.461803485468665 0.5079171184033603 3.925721166603597 1.8020952293713488 4.940790043836669 2.2372614104901762e-07 6.650283268250022 -6.923797974111375 SSHYDELLAAEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSHYDELLAAEAR 13 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 27739400.0 2512100.0 11182300.0 14045000.0 False True 3440891.256949894 10688229.011078887 10727860.265854774 1.0 3.10623853325526 3.1177562627667172 21.714350868391776 -10.650018792164756 0.9294084490131903 1.800758503738302e-08 3.114844247098643 0.9999953888024129 0.002137948540834602 2.3131326433562154 0.5294834175074841 5.376624375240176 0.0015548297972443927 2.238624269950293e-11 10.650018792164756 3.114844229091058 SSHYDELLAAEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSHYDELLAAEAR 13 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 11818600.0 3550200.0 3934800.0 4333600.0 False True 4595803.884904303 3715824.921032813 3544929.266490982 1.0 0.8085255624675523 0.7713404129655974 22.13188580501214 -13.999999999999998 0.230422048978942 2.2110871462753257 0.7533331238569645 0.9995103701620377 0.0022168085266700173 13.304551672289238 0.15198792670120603 7.37360154132408 0.01925198979114018 1.0000000000000041e-14 13.999999999999998 -1.4577540224183612 SSIAGLLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSIAGLLLK 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 7330400.0 2564600.0 1833300.0 2932500.0 False True 3362215.435621729 1559778.78614743 2629073.030526304 1.0 0.4639139924295188 0.7819466303890028 21.68098073826033 -10.30275252463187 5.923993291474024 1.0000279210827467 0.6229303114092664 0.6520889389721876 0.12983628075867554 4.788241326754008e-05 5.635847196202024e-06 0.1257227285660389 0.04190447942598788 4.980207928672334e-11 10.30275252463187 -0.3770976096734804 SSIAGLLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSIAGLLLK 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 3612660.0 914630.0 600430.0 2097600.0 False True 885595.5712931501 840184.8302010864 1548175.6333488608 1.0 0.9487229356558832 1.7481745432491365 19.756288481911533 -6.891593848498868 1.0128760011491118 0.9586715266732496 1.8191289799477897 0.9819000185993407 0.04915671258166455 0.11786070705280835 0.2143555332533447 0.03689831725721876 0.09253469498177963 1.283530377090407e-07 6.891593848498868 0.86045745327454 SSIAGLLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSIAGLLLK 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 9196400.0 2564600.0 3198000.0 3433800.0 False True 3512801.9257090506 3056701.7856282094 2622807.161330875 1.0 0.8701605869824902 0.7466424856281835 21.744190799783222 -6.971731216413336 0.21281929530522925 1.0623876408423116 0.5509563082946269 0.9999929171852416 0.00027523942140061697 0.07574490557516643 0.0069838182469045655 0.0036173332345960933 0.012717288739787906 1.067256438768334e-07 6.971731216413336 -0.5114313325476847 SSIAGLLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSIAGLLLK 9 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 2903760.0 914630.0 1001000.0 988130.0 False True 760555.3699791592 995607.4143170574 1194743.4144030889 1.0 1.3090531651158273 1.570882885799396 19.53669375734581 -6.97304596600227 0.17038089093541633 0.76985113238298 2.117099250937674 0.9999974354389958 0.0003736119742740616 0.07532616180233644 0.00531675399517649 0.0109956561560287 0.030296711198822827 1.0640303946153241e-07 6.97304596600227 1.3472481185546938 SSIFDADEEK(ub)SK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSIFDADEEKSK 12 1 Q9UJY4;H3BMM6 Q9UJY4 GGA2 ADP-ribosylation factor-binding protein GGA2 1 2175580.0 1203700.0 971880.0 0.0 True False 1165489.2023720678 1359956.752287246 0.0 1.0 1.1668548704864765 0.0 20.15250420806257 -6.928928021918647 1.242213906045158 1.0890060982930432 2.179523439166646e-21 0.9635784730990846 0.09833348154923156 0.11748955528474968 0.3621640335718577 0.06532226847546233 0.12647765774751143 1.177801160995002e-07 6.928928021918647 -1.0890060982930432 down SSIFDADEEK(ub)SK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSIFDADEEKSK 12 1 Q9UJY4;H3BMM6 Q9UJY4 GGA2 ADP-ribosylation factor-binding protein GGA2 1 3244320.0 1203700.0 1152700.0 887920.0 True False 1000929.8829514815 1146490.1763069653 1073579.966721778 1.0 1.1454250650667601 1.0725825904568564 19.932909483496847 -10.689664174868126 6.635711446109902 0.9990490826710003 1.1090038277618084 0.7491059287249162 0.029737815732650524 0.0004219134174963612 1.9731803212408336e-05 0.02903867959601653 0.009597838757095037 2.04331736166165e-11 10.689664174868126 0.10995474509080805 SSILLDVK(ub)PWDDETDMAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSILLDVKPWDDETDMAK 18 1 P24534 P24534 EEF1B2 Elongation factor 1-beta 1 11403300.0 2503000.0 3675700.0 5224600.0 True False 2423543.6350729303 5143426.178522278 3856120.525359681 1.0 2.1222750455522537 1.5911083545411968 21.208686627292323 -10.224524032452488 4.507932856295659 0.99972645371366 1.856691700056373 0.7762050528579734 0.21684789358941156 0.0005963489528418196 0.00010258659939786882 0.2100273687596048 0.06998735670638787 5.963153207592321e-11 10.224524032452488 0.856965246342713 SSILLDVKP ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSILLDVKP 9 1 E9PI39 E9PI39 EEF1D 0 4108930.0 456730.0 2048500.0 1603700.0 False True 625595.4236641566 1957990.4965163793 1224939.0892382541 1.0 3.1298031002980977 1.9580371641207017 19.254870433563575 -10.353207458100758 5.911786921359931 0.9997683004837542 2.5439201322094016 0.6983193687442931 0.4783714402682177 0.0014610724887665755 0.00015985321165126704 0.4632460055149366 0.15439371845500413 4.4339678715421785e-11 10.353207458100758 1.5441518317256473 SSILLDVKPWDDETDMAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 SSILLDVKPWDDETDMAK 18 1 P24534 P24534 EEF1B2 Elongation factor 1-beta 0 181605500.0 49015000.0 72884800.0 59705700.0 False True 64259139.661935255 62010671.942725286 53527926.90151547 1.0 0.9650093709464667 0.8330009891686029 25.93739832952493 -6.946220277240496 0.5989068966947081 1.0014905259652809 0.7897749787460386 0.9988702654023963 0.002416992501585305 0.0850399886016709 0.042524469515075235 0.0024833408563036856 0.011089707930678303 1.1318261473777629e-07 6.946220277240496 -0.21171554721924224 SSILLDVKPWDDETDMAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 SSILLDVKPWDDETDMAK 18 1 P24534 P24534 EEF1B2 Elongation factor 1-beta 0 276866500.0 84567200.0 63611000.0 128688300.0 False True 81882660.52574497 89011204.02698272 94980973.66375293 1.0 1.0870580346982794 1.1599644302457621 26.28705464328195 -6.973170197529408 0.16579507197885526 0.9318191080069237 1.317148106240311 0.9999977231718447 9.849947642793888e-05 0.07528673781585199 0.0051485720403925215 0.0031945560385134666 0.008568951575593764 1.0637260683528648e-07 6.973170197529408 0.3853289982333873 SSILLDVKPWDDETDMAK ddPTM_RPMI8226_Bortezomib_8h_R1 2 SSILLDVKPWDDETDMAK 18 1 P24534 P24534 EEF1B2 Elongation factor 1-beta 0 575063100.0 132921900.0 299024500.0 143116700.0 False True 201652240.19254965 245661241.68591788 114829621.51472211 1.0 1.2182420659019002 0.5694438177581161 27.587294192101453 -6.815963706458142 1.3890989936742222 1.1181339703543884 0.5564522243848594 0.8748828881385882 0.0953473234243479 0.19877624231817487 0.7547071135403413 0.0539514920897626 0.12451190027791036 1.5276937206920416e-07 6.815963706458142 -0.561681745969529 SSILLDVKPWDDETDMAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SSILLDVKPWDDETDMAK 18 1 P24534 P24534 EEF1B2 Elongation factor 1-beta 0 212929000.0 49015000.0 65990500.0 97923500.0 False True 67137170.08056976 63074821.50859856 74795986.0977878 1.0 0.9394918110623955 1.1140771350360295 26.000608391047823 -6.8130849236000435 1.4013523585283367 0.967142032426354 1.1173572210129488 0.8677832641535742 0.026319959895059537 0.20261411606320653 0.7835752262124943 0.014765276823613028 0.03411271937651814 1.5378538930814233e-07 6.8130849236000435 0.15021518858659477 SSILLDVKPWDDETDMAK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SSILLDVKPWDDETDMAK 18 1 P24534 P24534 EEF1B2 Elongation factor 1-beta 0 182280200.0 84567200.0 55272800.0 42440200.0 False True 70321373.7621788 54975034.45560819 51314249.59868633 1.0 0.7817684939081155 0.7297105681158473 26.067459918716228 -13.999999999999998 0.20132500868000894 2.219280112827925 0.6963397551856709 0.9994870323720648 0.0026519487864095116 12.557390605611637 0.14226725794800826 6.032498841343531 0.03282321351897343 1.0000000000000041e-14 13.999999999999998 -1.5229403576422542 SSILLDVKPWDDETDMAK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SSILLDVKPWDDETDMAK 18 1 P24534 P24534 EEF1B2 Elongation factor 1-beta 0 396965900.0 132921900.0 166084000.0 97960000.0 False True 172070019.8323647 156841279.40043032 80132285.1544805 1.0 0.9114968403748042 0.46569579774877434 27.358420514193902 -6.939640389418676 0.6629009282394843 1.005036204597485 0.3467387706160583 0.9981164133228451 0.010147922443200036 0.08793107959796216 0.0553597107966567 0.009851528033616799 0.038430400390504986 1.1491047254100168e-07 6.939640389418676 -0.6582974339814267 down SSILLDVKPWDDETDMAQLEACVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSILLDVKPWDDETDMAQLEACVR 24 1 P29692;E9PK01;E9PRY8;P29692-2;A0A087X1X7;P29692-4;E9PQZ1;H0YE72;H0YE58;P29692-3 P29692;P29692-3 EEF1D Elongation factor 1-delta 0 38773000.0 12321000.0 11582000.0 14870000.0 False True 18691857.785755455 9515101.609420976 11930937.982247468 1.0 0.5090506100828656 0.638295995989211 24.155906630036096 -10.262861932209479 8.306265449365092 1.0000003212758373 0.5736733030360608 0.9355152283387724 0.0527642078466078 3.139229050374739e-07 2.7862084808735575e-08 0.0510887633898563 0.017029574855478232 5.459313921032177e-11 10.262861932209479 -0.4263270182397765 SSILQAESK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSILQAESKK 10 1 Q9UKG1 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 1 5180360.0 487320.0 407240.0 4285800.0 True False 471850.2933454813 569853.0557285441 3163220.40875598 1.0 1.2076988480566797 6.703864453126281 18.847969674474747 -6.914884748557914 0.8617937934057529 0.8549732196892936 7.493718099858607 0.992638336411283 0.22661822483192715 0.10127610034962205 0.12189681520109726 0.19013847199020303 0.5444637820178856 1.2165087903580217e-07 6.914884748557914 6.638744880169313 up SSIPITVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSIPITVR 8 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 11664800.0 1594500.0 3910700.0 6159600.0 False True 2090404.9411599631 3327238.80378921 5522263.679055348 1.0 1.591671899676495 2.6417195875891157 20.99535100924522 -6.962312923597947 0.4015090145244777 0.9432295471233749 3.3285968553000704 0.9998465963052034 0.00840836751580005 0.07888501479243722 0.01815278930018752 0.01350902191083672 0.08792780467547132 1.0906542006900332e-07 6.962312923597947 2.3853673081766953 SSIPITVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSIPITVR 8 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 6149700.0 2445300.0 1058300.0 2646100.0 False True 2367675.289989547 1480884.7089615923 1953007.028701573 1.0 0.6254593757947824 0.8248626984277879 21.175039808380916 -10.545823357193145 7.752177500911275 1.0000828354806546 0.725161037111309 0.7169522641044026 0.08140606557773863 0.00011658235768258021 6.830192722093284e-06 0.07884466735052655 0.026273694688570902 2.8456182849197954e-11 10.545823357193145 -0.2749217983693456 SSIPITVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSIPITVR 8 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 8899500.0 1594500.0 4195600.0 3109400.0 False True 2184029.7397422893 4010224.519006164 2375023.7601031545 1.0 1.8361583846744511 1.087450283705112 21.05856107076811 -10.255134646513406 4.555151762219492 0.9998131542270985 1.4618043341927374 0.3365439768440798 0.3056588022872491 0.0005802277488954225 9.487988846348816e-05 0.2960714392545671 0.09865095423860079 5.557319341781322e-11 10.255134646513406 0.4619911799656389 SSIWQFFSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSIWQFFSR 9 0 O60271-9;O60271-4;O60271;O60271-5;O60271-3 O60271-9 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 0 13528300.0 3135200.0 4181200.0 6211900.0 False True 4110277.561319994 3557381.258189946 5569152.176752367 1.0 0.8654844362986308 1.3549333575817841 21.97080438970781 -6.83344726401352 1.3125480369058535 0.9282792790632913 1.3690453716178141 0.912574463003107 0.06104576228411435 0.17659635620926653 0.5937956131846012 0.03650461852373838 0.08400514097844078 1.4674142628775473e-07 6.83344726401352 0.4407660925545228 SSIWQFFSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSIWQFFSR 9 0 O60271-9;O60271-4;O60271;O60271-5;O60271-3 O60271-9 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 0 12482400.0 4563200.0 2354400.0 5564800.0 False True 4418343.713769394 3294524.1980338 4107211.939578444 1.0 0.7456468784369795 0.9295818083999816 22.075074223160517 -10.464305254752729 5.1528254188487645 1.000281972117425 0.8376143434184767 0.5096153554176074 0.0750911207139993 0.00024366348826059762 2.533166968709843e-05 0.0728321035658227 0.024235554997778925 3.433165544370616e-11 10.464305254752729 -0.16266762869894824 SSIWQFFSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSIWQFFSR 9 0 O60271-9;O60271-4;O60271;O60271-5;O60271-3 O60271-9 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 0 16387400.0 3135200.0 5197000.0 8055200.0 False True 4294368.165594256 4967379.355819195 6152727.6620515045 1.0 1.1567194903355027 1.4327434036387723 22.0340144512307 -6.962452719530163 0.3993691830339449 0.9847206368797506 1.6148106194393246 0.9998506214538633 0.002186404167388438 0.0788363641489471 0.017977594395087847 0.0035519164444097286 0.023131734252094357 1.0903031842935222e-07 6.962452719530163 0.6300899825595739 SSIWQFFSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSIWQFFSR 9 0 O60271-9;O60271-4;O60271;O60271-5;O60271-3 O60271-9 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 0 9629200.0 4563200.0 2186900.0 2879100.0 False True 3794502.984036056 2175118.735634337 3481106.498545669 1.0 0.5732288905254077 0.9174077641238169 21.855479498594793 -9.920416329528257 6.627802439377303 1.0000000178127266 0.745318327324607 0.4219893808892776 0.14051043676034797 3.6988189553110904e-08 5.811636523229506e-09 0.1360486555216853 0.04534954846176035 1.201112455106058e-10 9.920416329528257 -0.2546816904881196 SSIWQFFSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSIWQFFSR 9 0 O60271-9;O60271-4;O60271;O60271-5;O60271-3 O60271-9 SPAG9 C-Jun-amino-terminal kinase-interacting protein 4 0 9045900.0 1445000.0 4192100.0 3408800.0 False True 1870580.985208362 3958805.949847935 2788433.37724166 1.0 2.116351005998795 1.4906777088461953 20.835054996816375 -10.504248681293701 6.245856613177577 0.9993564210143071 1.803514357422492 0.6874050587296265 0.25543005395143753 0.0022907522455791656 0.00018182352325370492 0.24749585348903533 0.08243969542289835 3.131492087655001e-11 10.504248681293701 0.804157936408185 SSK(ub)EDGHILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSKEDGHILR 10 1 Q6SJ93;Q6SJ93-2;E9PS27 Q6SJ93 FAM111B Protein FAM111B 1 17767200.0 5190800.0 5996900.0 6579500.0 True False 6805189.067778712 5102185.895733109 5898716.455020556 1.0 0.7497493228940542 0.8667968510896878 22.698203813839275 -10.068200373707144 4.500281668897472 1.0000119847234403 0.8082730869812637 0.78154043803045 0.04778445332776077 66314767.78345467 0.2224749595512737 8440.868104434892 0.016357889360248595 8.546722953275613e-11 10.068200373707144 -0.19173889774217667 SSK(ub)EDGHILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSKEDGHILR 10 1 Q6SJ93;Q6SJ93-2;E9PS27 Q6SJ93 FAM111B Protein FAM111B 1 11554800.0 6792400.0 4762400.0 0.0 True False 6576778.979971785 6664051.155587917 0.0 1.0 1.013269744335624 0.0 22.648949757027488 -7.013664782277033 1.1014335705633105 1.0261927776980317 3.5615040245141564e-21 0.9849035765594318 0.05830838941509619 0.08939103581719963 0.2112847770217793 0.04461151170114005 0.08120821450465603 9.690255268207331e-08 7.013664782277033 -1.0261927776980317 down SSK(ub)EDGHILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSKEDGHILR 10 1 Q6SJ93;Q6SJ93-2;E9PS27 Q6SJ93 FAM111B Protein FAM111B 1 11179900.0 2582900.0 0.0 8597000.0 True False 3918448.1352834795 0.0 6897799.18180104 1.0 0.0 1.7603395384234222 21.901850970906136 -6.752625767937806 1.6402849172621532 0.41383982621859167 1.7645124054299395 0.6601056224007309 0.42027185971542724 0.29549995432016224 1.5650629453624594 0.20234142222715903 0.48985327873489287 1.7675602733939352e-07 6.752625767937806 1.3506725792113479 SSK(ub)EDGHILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSKEDGHILR 10 1 Q6SJ93;Q6SJ93-2;E9PS27 Q6SJ93 FAM111B Protein FAM111B 1 13291100.0 5190800.0 4075200.0 4025100.0 True False 7109979.036095514 3895144.1891157217 3074454.2795366333 1.0 0.5478418669508149 0.4324139725206542 22.761413875362166 -13.999999999999849 0.19171714529430753 3.4383917013620997 0.35102048833796384 0.9994885550078537 0.005539167294701749 12.379197599285554 0.1388541017817674 11.282911118838044 0.07831081225809394 1.0000000000003477e-14 13.999999999999849 -3.0873712130241358 SSK(ub)EDGHILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSKEDGHILR 10 1 Q6SJ93;Q6SJ93-2;E9PS27 Q6SJ93 FAM111B Protein FAM111B 1 15379500.0 6792400.0 6212600.0 2374500.0 True False 5648181.554340489 6179131.490695446 2870996.971552462 1.0 1.0940036950382614 0.5083046541494707 22.429355032461764 -6.865783869252879 1.1560751062565109 1.052030619153856 0.47663046688900995 0.9602960862317036 0.05117508590727025 0.14096649179206017 0.3547649910733121 0.034433164113053694 0.08098154267351103 1.3621223868784064e-07 6.865783869252879 -0.575400152264846 SSK(ub)MLQHIDYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSKMLQHIDYR 11 1 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3;J3KRY3;S4R3P3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 1 5588100.0 0.0 0.0 5588100.0 True False 0.0 0.0 4124408.970593426 0.0 SSLIILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSLIILK 7 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 35629000.0 8611700.0 7544300.0 19473000.0 False True 11290022.095821422 6418719.84745107 17458120.758205872 1.0 0.5685303175648097 1.5463318503749732 23.428544973838907 -6.786749852519589 1.5092544094108615 0.757831194550157 1.5558267562749164 0.7906445498431873 0.18306855362522992 0.24022525459909472 1.081030866331786 0.09549343949028144 0.22411806047478805 1.6339928336664987e-07 6.786749852519589 0.7979955617247594 SSLIILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSLIILK 7 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 23974000.0 8490000.0 4660000.0 10824000.0 False True 8220489.597191049 6520762.30157897 7988869.686960377 1.0 0.7932328390522047 0.9718240735552033 22.970792890044393 -10.179579938585295 6.346273816086621 1.0000007299990925 0.88252845634181 0.36583543994614287 0.07290956617768078 7.53085659752575e-07 9.738335483436886e-08 0.07059482307497329 0.023531461298780334 6.613327977978145e-11 10.179579938585295 -0.11747227365728252 SSLIILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSLIILK 7 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 33590800.0 6241000.0 22234000.0 5115800.0 False True 9468053.278216036 18266168.98496509 4104659.8876652108 1.0 1.9292423107706453 0.43352733313290015 23.17463639369009 -6.738684419487605 1.691635970353024 1.5537290373793489 0.43291253251872475 0.5990152407527817 0.39043960099698394 0.3201774123115965 1.7985343854570928 0.18263420026586616 0.448795459410815 1.825221519570361e-07 6.738684419487605 -1.120816504860624 SSLIILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSLIILK 7 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 30671000.0 8611700.0 9634300.0 12425000.0 False True 11795678.212441942 9208624.769630335 9490470.900907487 1.0 0.7806778553790309 0.8045718720011411 23.4917550353618 -9.938886110553565 5.4628664318646765 1.000000331156498 0.7926248637856639 0.9901412124690712 0.009754691440458369 3.933826459229834e-08 7.651675431899587e-09 0.009444954432220716 0.003148313124376665 1.1511022145750674e-10 9.938886110553565 -0.20737546737083412 SSLIILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSLIILK 7 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 14662000.0 8490000.0 3584200.0 2587800.0 False True 7059811.170771859 3564891.203191999 3128897.0153646884 1.0 0.5049556024884791 0.44319840002499694 22.75119816547867 -13.999999999999998 0.2935283573693673 5.351758385543377 0.4269597160389426 0.9996353610815368 0.004758622313303236 16.178972207439134 0.1718908197144217 42.60231441975142 0.02295861445992482 1.0000000000000041e-14 13.999999999999998 -4.924798669504434 SSLIILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSLIILK 7 0 P28066;P28066-2 P28066 PSMA5 Proteasome subunit alpha type-5 0 19455000.0 6241000.0 7164600.0 6049400.0 False True 8079097.528501998 6765883.711810441 4948471.2720856955 1.0 0.837455382601991 0.6125029750696952 22.94576271578254 -6.966560880587406 0.3301677976177098 1.0273528004567736 0.41523957798695504 0.9999417980842876 0.001212064871510678 0.07743519962734044 0.01301351810938232 0.0032804516085855125 0.0196181972425642 1.0800382075616767e-07 6.966560880587406 -0.6121132224698185 SSLLCLDLGLNHIGVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSLLCLDLGLNHIGVK 16 0 Q9NX02;A0A0G2JPQ2;A0A0G2JMG8;Q9NX02-5;J3KN39;A0A0G2JLX3;Q9NX02-2;Q9NX02-4 Q9NX02 NLRP2 NACHT, LRR and PYD domains-containing protein 2 0 101102000.0 31683000.0 34215000.0 35204000.0 False True 48065427.33756104 28109065.926984876 28245913.969538633 1.0 0.5848084056254477 0.5876555256893696 25.518496224683137 -10.688633450329782 10.128243002935696 1.0002905098473422 0.5862319656574114 0.9999644897076607 0.0011623318988415044 7.629782335952349e-06 2.3455770706212576e-07 0.0011261614920753807 0.0003751410072482289 2.048172589262986e-11 10.688633450329782 -0.4140585441899308 SSLLCLDLGLNHIGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSLLCLDLGLNHIGVK 16 0 Q9NX02;A0A0G2JPQ2;A0A0G2JMG8;Q9NX02-5;J3KN39;A0A0G2JLX3;Q9NX02-2;Q9NX02-4 Q9NX02 NLRP2 NACHT, LRR and PYD domains-containing protein 2 0 65907000.0 31683000.0 18462000.0 15762000.0 False True 41014268.06529861 17434573.470597718 12893477.731777463 1.0 0.42508556882790693 0.3143656668759716 25.289622546775586 -13.99999999999998 0.23160780446583487 4.656477911933666 0.2613496704948147 0.9995120312887409 0.006638772277742796 13.341924722147894 0.1523694233463437 22.45457028336296 0.05690437976603449 1.000000000000045e-14 13.99999999999998 -4.395128241438852 SSLLK(ub)EQMLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSLLKEQMLR 10 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 15241600.0 3303600.0 3926400.0 8011600.0 True False 3198729.0262992135 5494231.995905508 5913121.61715186 1.0 1.7176297056528382 1.8485847249127811 21.609067352033346 -11.176564707659967 0.30910645686620536 1.2977728085652201e-09 1.8831286640311735 0.9993152417677349 0.009760918317710648 3.208975486807128 0.1599243807416941 2.270770355690404 0.04540503014401508 6.659402922035496e-12 11.176564707659967 1.8831286627334007 SSLLK(ub)EQMLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSLLKEQMLR 10 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 8714600.0 1448000.0 3016300.0 4250300.0 True False 1983364.7307286537 2883029.892429756 3246466.677676225 1.0 1.453605505715825 1.6368480428123422 20.919518575599056 -11.4649659103562 0.1624540973460133 6.909496313874509e-16 1.841743560361399 0.9995548138652971 0.005648059939918171 4.125119047078738 0.1007926958339784 1.6205717203422367 0.15593954132323706 3.427946929218353e-12 11.4649659103562 1.8417435603613983 SSLLK(ub)EQMLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSLLKEQMLR 10 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 15395700.0 3303600.0 7379200.0 4712900.0 True False 2747089.774294687 7339446.78494349 5698345.600012455 1.0 2.671717121741275 2.0743208515912084 21.389472627467622 -10.213472476942805 5.2921194858215825 0.9999055379980785 2.37301898666653 0.8756705693096685 0.24388600601933585 0.0002718480424562588 4.040278803763161e-05 0.23615753748280147 0.0787138699736712 6.116845667349143e-11 10.213472476942805 1.3731134486684513 SSLLK(ub)EQMLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSLLKEQMLR 10 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 10078000.0 2078900.0 2360400.0 5638700.0 True False 2691177.031245441 2229041.6650416437 4612514.457947822 1.0 0.8282776046175129 1.7139394415138909 21.35980586691687 -6.856420571044205 1.203629776816342 0.9075751020286356 1.7539982902306144 0.9491450836111955 0.08648141264517259 0.1505360175757478 0.41644895667380133 0.05611426477945868 0.1305089156474094 1.391808322078085e-07 6.856420571044205 0.8464231882019788 SSLLLGFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSLLLGFR 8 0 P42704 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 88157000.0 25374000.0 28926000.0 33857000.0 False True 33265559.722165573 24610353.552664857 30353802.419276718 1.0 0.7398148042062385 0.9124693127905289 24.98752597274292 -10.165608113928148 4.666482690392289 1.0000222084989194 0.8261420584967586 0.5748272650822144 0.07048590797597912 1.628800815998093e-05 2.9125157416164827e-06 0.06825640136677277 0.022749228976986162 6.829546810396347e-11 10.165608113928148 -0.17388015000216084 SSLLLGFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSLLLGFR 8 0 P42704 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 47612800.0 12781000.0 8051800.0 26780000.0 False True 12375274.1509657 11266925.729582304 19765514.617220897 1.0 0.9104384753127343 1.5971779191395532 23.56095714995794 -6.8740908290814415 1.112185410685499 0.9478457272543365 1.6406593107740464 0.9686002191600134 0.054014592347444844 0.13299514377444357 0.3049907135905303 0.037588624596918724 0.08968432629316912 1.336316007932156e-07 6.8740908290814415 0.6928135835197099 SSLLLGFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSLLLGFR 8 0 P42704 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 58169000.0 14541000.0 19714000.0 23914000.0 False True 22059760.089495156 16195882.673814964 19187387.418121435 1.0 0.7341821764202882 0.86979130055265 24.39491376522344 -10.235128907057918 5.284433563126152 1.0000172822561615 0.8019867385454251 0.7397744817425375 0.05536219309992768 1.1728296815107984e-05 1.697544581426768e-06 0.05360907800809658 0.01786807099022301 5.8193046384195314e-11 10.235128907057918 -0.19803054371073636 SSLLLGFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSLLLGFR 8 0 P42704 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 74829000.0 25374000.0 19422000.0 30033000.0 False True 34755453.50656692 18563871.82003472 22939823.94905064 1.0 0.5341283150434836 0.6600352357570659 25.05073603426581 -10.30703467295782 8.45285865147375 1.0000005593439585 0.5970817754002854 0.9317612158779247 0.051401285138889134 5.418039522479867e-07 4.439436416459389e-08 0.049769149293657326 0.016589693443048035 4.931344317947274e-11 10.30703467295782 -0.4029187839436731 SSLLLGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSLLLGFR 8 0 P42704 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 33544600.0 12781000.0 8713600.0 12050000.0 False True 10627967.794303313 8666658.107285826 14569599.287095046 1.0 0.8154576937964785 1.3708734886178788 23.341362425392216 -6.8171368435883295 1.3841564450265464 0.9002345463942504 1.3822756908001719 0.8776810938536924 0.08077681750684422 0.19723069808000432 0.7432487127356066 0.04586746902736717 0.10580940861895172 1.523572609558148e-07 6.8171368435883295 0.4820411444059215 SSLLLGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSLLLGFR 8 0 P42704 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 62217000.0 14541000.0 27362000.0 20314000.0 False True 18823611.145961776 25839280.64686891 16617060.439241692 1.0 1.3727058238988434 0.8827775027007262 24.16604008731589 -6.703333238413595 1.8188816122379896 1.2306780483690802 0.8841371172992866 0.4333997201935502 0.1572305044798881 0.3886596934872322 2.5020275694272227 0.06890150927278232 0.17647769855842102 1.9800071638692357e-07 6.703333238413595 -0.34654093106979367 SSLLTEK(ub)LLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSLLTEKLLR 10 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 114354100.0 29778800.0 46898000.0 37677300.0 True False 39040295.17830943 39901001.2069722 33778814.42218195 1.0 1.0220466065825489 0.8652294832276081 25.218460625172614 -6.871299433191696 1.1271268958726735 1.012573813090645 0.8558129278099312 0.9659665653891832 0.01278728155395092 0.13561871918671203 0.32120893588276583 0.00879711915564844 0.020876964288622728 1.3449327429914525e-07 6.871299433191696 -0.15676088528071375 SSLLTEK(ub)LLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSLLTEKLLR 10 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 189997000.0 61991000.0 54888000.0 73118000.0 True False 60023129.63715778 76805064.63713863 53966202.30701853 1.0 1.2795911359742207 0.899090111316194 25.839015207977713 -6.70979357515741 1.7958323589731056 1.1719261035990078 0.8999869547197584 0.46408921802851333 0.11782264485406525 0.3755334748114947 2.360683611253339 0.05221206812246018 0.13268177712122445 1.9507716021767735e-07 6.70979357515741 -0.2719391488792494 SSLLTEK(ub)LLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSLLTEKLLR 10 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 332514000.0 96251000.0 125413000.0 110850000.0 True False 146019803.89065394 103032070.29375857 88940448.91271906 1.0 0.7056034013777578 0.609098536930796 27.121588806541755 -13.999999999999961 0.15592613540918956 2.438083981014915 0.5098320989532964 0.9995476796843582 0.00353601923590799 11.985011229886753 0.12463612331876517 5.215082597956757 0.09003262449650039 1.00000000000009e-14 13.999999999999961 -1.9282518820616183 SSLLTEK(ub)LLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSLLTEKLLR 10 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 141885000.0 29778800.0 39631200.0 72475000.0 True False 40788827.10181108 37880162.54114722 55357897.669478476 1.0 0.9286896739294885 1.35718287587192 25.281670686695506 -6.8641322455393645 1.1646080692100031 0.9607937280434644 1.3796387835690989 0.9584722249780334 0.03820127787762953 0.14260947566630833 0.36521245382062123 0.025536392981705448 0.05991807269904389 1.3673124065355062e-07 6.8641322455393645 0.41884505552563445 SSLLTEK(ub)LLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSLLTEKLLR 10 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 195515500.0 61991000.0 83401000.0 50123500.0 True False 51548263.16693965 82951702.25919761 60604092.105120964 1.0 1.6092046009495518 1.1756767033809443 25.61942048341199 -10.356035252832717 4.886224120939784 0.9997199614025053 1.3924406521653905 0.5221206550230857 0.17698702305126973 0.0005403060294584028 7.12080433560885e-05 0.17148750669722468 0.05712231606429602 4.4051910395345826e-11 10.356035252832717 0.3927206907628852 SSLLTEK(ub)LLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSLLTEKLLR 10 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 262814000.0 96251000.0 102262000.0 64301000.0 True False 124598816.89085808 96571029.80447735 52598877.783975564 1.0 0.7750557526486661 0.4221458846599593 26.892715128634205 -6.964500590986123 0.3665261909088095 1.0282306522688747 0.1567535383303281 0.9999024721716493 0.0023486942347165454 0.07813087945303532 0.015460259129078427 0.004677660420415026 0.030029451432462134 1.0851740729314143e-07 6.964500590986123 -0.8714771139385465 down SSLLTELSNSLTK(ub)DSMNIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSLLTELSNSLTKDSMNIK 19 1 Q9UBK9-2;Q9UBK9 Q9UBK9-2 UXT Protein UXT 1 35309700.0 6417700.0 10454000.0 18438000.0 True False 9736120.096716402 8588402.02252519 14793721.218337528 1.0 0.8821175105904567 1.5194678240798252 23.214915533377106 -6.858937343000643 1.1910123026787436 0.9362076585302688 1.5497219533632218 0.952337813002068 0.06044734337532434 0.14790890790974986 0.39927257165527924 0.03959966620381192 0.09233462102633305 1.3837660047445127e-07 6.858937343000643 0.613514294832953 SSLLTELSNSLTK(ub)DSMNIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSLLTELSNSLTKDSMNIK 19 1 Q9UBK9-2;Q9UBK9 Q9UBK9-2 UXT Protein UXT 1 33050700.0 6417700.0 7876000.0 18757000.0 True False 8307839.161779727 7437693.676439572 15343418.463072572 1.0 0.8952621170925811 1.846860316417785 22.986041855469555 -6.8796076819211045 1.0820239128927387 0.935422092444299 1.9137837797259252 0.9733659087000238 0.06953146636593598 0.12797636009503627 0.2744122644312429 0.04952004647308204 0.11962986014477403 1.3194481182248756e-07 6.8796076819211045 0.9783616872816262 SSLNPILFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSLNPILFR 9 0 A0A0C4DGS1;P39656;P39656-3;P39656-2;U3KQ84 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 0 8897400.0 2445500.0 3513000.0 2938900.0 False True 3206074.1822556914 2988874.093566749 2634810.819919434 1.0 0.9322535673406884 0.821818420329147 21.61237637633075 -6.963837848996504 0.3774665846413625 1.0078052521304206 0.7423771172293595 0.9998871423450321 0.0007801106290438544 0.07835757214831358 0.0162642329065883 0.001441181057342603 0.00934317535946645 1.0868313342663665e-07 6.963837848996504 -0.2654281349010611 SSLNPILFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSLNPILFR 9 0 A0A0C4DGS1;P39656;P39656-3;P39656-2;U3KQ84 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 0 9451400.0 2445500.0 3708200.0 3297700.0 False True 3349667.4371525743 3544359.4626224306 2518851.1782633867 1.0 1.0581227925227576 0.7519705240961374 21.675586437853642 -6.857560528048228 1.1979372385686744 1.0313547434775354 0.7378169658025648 0.9506092315793735 0.02950454627898178 0.1493403844545275 0.40861882411416256 0.019227276097083516 0.04476790538687646 1.3881598272487412e-07 6.857560528048228 -0.2935377776749706 SSLNSSPWSGLMALGNSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSLNSSPWSGLMALGNSR 18 0 Q8TCJ2 Q8TCJ2 STT3B Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B 0 2398400.0 0.0 1037200.0 1361200.0 False True 0.0 882453.8029739351 1220356.0815523956 0.0 SSMSVTSLEAELQAK(ub)IQESHPELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSMSVTSLEAELQAKIQESHPELR 24 1 Q9H9B4 Q9H9B4 SFXN1 Sideroflexin-1 1 33461600.0 5919600.0 14071000.0 13471000.0 True False 8980465.98072867 11559920.112775207 10808450.945450965 1.0 1.287229430809251 1.2035512376133932 23.09835887516417 -10.11196620786528 4.3980618789459465 0.9999722801057348 1.2453903341695076 0.9197847116390012 0.03416147941043464 23807515.06728839 0.32621633517011545 7352.166459631486 0.011694383030632092 7.727407091436982e-11 10.11196620786528 0.24541805406377282 SSMSVTSLEAELQAK(ub)IQESHPELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSMSVTSLEAELQAKIQESHPELR 24 1 Q9H9B4 Q9H9B4 SFXN1 Sideroflexin-1 1 22712000.0 5919600.0 6116400.0 10676000.0 True False 7663038.89276084 5776016.963252295 8733077.545010546 1.0 0.7537501824124647 1.1396363332124748 22.86948519725662 -6.7343321446132425 1.707504976239517 0.852525908829667 1.139591106913148 0.5791822294527726 0.1034871834456174 0.32818439717538267 1.8764357341966469 0.04799209091402502 0.1185063156371445 1.843604907000558e-07 6.7343321446132425 0.28706519808348097 SSMTFLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSMTFLTR 8 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 39286000.0 12597000.0 12976000.0 13713000.0 False True 16514788.989521546 11040031.380051829 12294110.304384373 1.0 0.6684936384628716 0.7444303594908086 23.977255200549134 -9.983621667958944 5.583533969437672 1.0000006204137144 0.7064619989765558 0.9522066466922651 0.031001036544093412 2.3942094259294084e-07 4.357862698055484e-08 0.030016688074424314 0.010005541520723828 1.0384326439027959e-10 9.983621667958944 -0.2935386214371586 SSMTFLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSMTFLTR 8 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 21223300.0 6260100.0 4370200.0 10593000.0 False True 6061376.552105488 6115243.650291924 7818375.516811828 1.0 1.00888694139415 1.2898679779424076 22.531214039486557 -6.913641061873389 0.8705916628104032 0.992269541307464 1.3291542009728492 0.9922240128704563 0.011869175326862704 0.10205935672956745 0.1260787276154294 0.009895853668415461 0.028057165050557772 1.2199974926975725e-07 6.913641061873389 0.33688465966538517 SSMTFLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSMTFLTR 8 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 30405000.0 12597000.0 8740100.0 9067900.0 False True 17254451.32112491 8353933.482354318 6926248.779262684 1.0 0.4841610623762031 0.4014180833894592 24.040465262072026 -13.999999999999998 0.25756458525389925 4.728726532667147 0.37046311226661965 0.9995574047143696 0.005571574767015257 14.31082792375399 0.16059445138162284 27.733193256128178 0.03664419687551662 1.0000000000000041e-14 13.999999999999998 -4.358263420400527 SSMTFLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSMTFLTR 8 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 15989100.0 6260100.0 6443000.0 3286000.0 False True 5205550.51945216 6408290.2801646255 3973087.4072526386 1.0 1.2310494838572892 0.7632405818377827 22.311619314920833 -6.772412705008378 1.565281916450041 1.132113917034594 0.7603694914526771 0.7396955418925544 0.09744160803670422 0.26253812815884825 1.269801905475667 0.049059436505775635 0.11652222535717816 1.6888352882678457e-07 6.772412705008378 -0.3717444255819169 SSNFLYLQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSNFLYLQVK 10 0 Q9BUP3-3;Q9BUP3 Q9BUP3-3 HTATIP2 Oxidoreductase HTATIP2 0 7461700.0 2181600.0 3109800.0 2170300.0 False True 2860098.7266444545 2645829.9619054543 1945738.1749876342 1.0 0.925083437595042 0.6803045492315669 21.44763351702086 -6.949518035741601 0.5641179225094145 1.003135038627795 0.5904717458744952 0.9991628573906124 0.003949926779774338 0.08368002328456217 0.036768960273159644 0.004213342094733572 0.020366430040737543 1.1232643208529486e-07 6.949518035741601 -0.4126632927532998 SSNFLYLQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSNFLYLQVK 10 0 Q9BUP3-3;Q9BUP3 Q9BUP3-3 HTATIP2 Oxidoreductase HTATIP2 0 11759900.0 5079700.0 3188900.0 3491300.0 False True 4918447.703987206 4462244.399893807 2576823.7932450827 1.0 0.9072464867881849 0.5239099708544518 22.22977163222168 -6.944124441297855 0.6200058557298891 1.004195462457584 0.4066522790102619 0.9986557511400143 0.007555627015202092 0.08593438416477446 0.04641233820842845 0.007609051083967658 0.032441971919250794 1.1373013605778378e-07 6.944124441297855 -0.597543183447322 SSNFLYLQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSNFLYLQVK 10 0 Q9BUP3-3;Q9BUP3 Q9BUP3-3 HTATIP2 Oxidoreductase HTATIP2 0 10929700.0 2181600.0 3531300.0 5216800.0 False True 2988196.4755232274 3375275.489552496 3984699.283368541 1.0 1.1295359984525422 1.3334796811413907 21.510843578543753 -6.964440024862825 0.36753604212940844 0.9838718813678785 1.486215380919386 0.99990113127574 0.001364876333620556 0.0781514902980331 0.015533088503685165 0.0026986280905069568 0.017344055779561062 1.0853254203986237e-07 6.964440024862825 0.5023434995515076 SSNLLDLK(ub)NPFFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSNLLDLKNPFFR 13 1 Q86X55-1;Q86X55;K7EQB9 Q86X55-1 CARM1 Histone-arginine methyltransferase CARM1 1 6584900.0 1517000.0 2082600.0 2985300.0 True False 1988801.6906488966 1771884.1979112178 2676409.793019664 1.0 0.8909305569491426 1.3457399023762988 20.923467997239992 -6.843403420842531 1.266577152705363 0.9419810554347787 1.3617282197307508 0.9301423116670463 0.05124204164537154 0.16485575586263795 0.5122600924147678 0.0317054700434412 0.07312038564706631 1.4341566108220532e-07 6.843403420842531 0.41974716429597203 SSNLLDLK(ub)NPFFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSNLLDLKNPFFR 13 1 Q86X55-1;Q86X55;K7EQB9 Q86X55-1 CARM1 Histone-arginine methyltransferase CARM1 1 14139400.0 4327900.0 4768800.0 5042700.0 True False 4190513.1834726837 6673006.708963463 3721865.5922427117 1.0 1.5924079979706767 0.8881646302705095 21.998695501056773 -6.683660125665804 1.8891295985747008 1.373587697743636 0.8907786984652704 0.3408762856317551 0.2508783589965903 0.4304238285801968 2.9730264346725797 0.10644537468377151 0.27940767251750714 2.071762053920988e-07 6.683660125665804 -0.48280899927836574 SSNLLDLK(ub)NPFFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSNLLDLKNPFFR 13 1 Q86X55-1;Q86X55;K7EQB9 Q86X55-1 CARM1 Histone-arginine methyltransferase CARM1 1 12454600.0 4327900.0 3826800.0 4299900.0 True False 3598840.6084786197 3806184.268839676 5198989.209508705 1.0 1.057614015989641 1.4446289166739548 21.77910077649105 -6.933494102494339 0.7175267112236262 0.9948091604750098 1.5316472730211879 0.9971816182166168 0.010481058700697096 0.09086347360432312 0.06908544977058367 0.009755624861082238 0.03437013705869039 1.1654828774145203e-07 6.933494102494339 0.5368381125461781 SSNQTAPSLNNIIK(ub)AATCEGSESSGFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSNQTAPSLNNIIKAATCEGSESSGFGK 28 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 13639800.0 5926400.0 3676900.0 4036500.0 True False 4928064.184035614 3657091.8098924956 4880513.487332708 1.0 0.742095003904289 0.9903510394899186 22.232589615411143 -10.666459606887079 8.801309656256509 1.000155163332765 0.8662230217336531 0.2791079022236611 0.10135010212516926 0.0003089311997215955 1.1707529642933988e-05 0.09824466840604851 0.03271060480560012 2.155462110712884e-11 10.666459606887079 -0.13393214159911193 SSNVSYK(ub)YSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSNVSYKYSK 10 1 P11717 P11717 IGF2R Cation-independent mannose-6-phosphate receptor 1 16432000.0 4962800.0 6531000.0 4938200.0 True False 6506278.85982357 5556600.257638609 4427242.434559238 1.0 0.8540365971632036 0.680456913996965 22.633401227095614 -6.968828273198993 0.28478547900475926 1.0361027851650086 0.4930665018055246 0.9999717438241367 0.000694281256300995 0.07668475805042692 0.010384598689784726 0.0031203880554566193 0.015838444591316638 1.0744141684511756e-07 6.968828273198993 -0.5430362833594841 SSNVSYK(ub)YSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSNVSYKYSK 10 1 P11717 P11717 IGF2R Cation-independent mannose-6-phosphate receptor 1 10521900.0 3238800.0 3974300.0 3308800.0 True False 3135986.066829484 5561258.715700708 2442126.018127723 1.0 1.7733684388857 0.7787426238780261 21.580487718904635 -6.699142669351116 1.833634012845258 1.4806176839000156 0.7817149074025936 0.4136856606986642 0.3264975982961242 0.3972839664417416 2.59622784937926 0.1420763329597427 0.36580977836457385 1.9992050062659537e-07 6.699142669351116 -0.6989027764974219 SSNVSYK(ub)YSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSNVSYKYSK 10 1 P11717 P11717 IGF2R Cation-independent mannose-6-phosphate receptor 1 14386100.0 4962800.0 4708300.0 4715000.0 True False 6797681.274627188 4500271.737733985 3601414.108473137 1.0 0.6620304124189462 0.5298003779488253 22.696611288618506 -13.999999999998623 0.1297340997311319 2.6060576754093847 0.34399445707531723 0.9996468213586162 0.0037208075562293413 11.937147014105461 0.11198311308886509 4.889886797662898 0.1652268208139968 1.00000000000317e-14 13.999999999998623 -2.2620632183340676 SSNVSYK(ub)YSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSNVSYKYSK 10 1 P11717 P11717 IGF2R Cation-independent mannose-6-phosphate receptor 1 11173700.0 3238800.0 4974100.0 2960800.0 True False 2693205.703167945 4947303.536018448 3579889.5908075445 1.0 1.8369571734528367 1.3292299160797918 21.36089299433891 -10.13533194961543 4.438425098755484 0.9999207124792298 1.5830935445205867 0.6374904570909539 0.2072787849474421 72394341.8015644 10.563930555183168 62678.68094211106 0.07095704136442221 7.322646184070628e-11 10.13533194961543 0.583172832041357 SSNVSYK(ub)YSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSNVSYKYSK 10 1 P11717 P11717 IGF2R Cation-independent mannose-6-phosphate receptor 1 6453670.0 4232300.0 1581500.0 639870.0 True False 5478795.781105433 1493488.134749769 523420.2256206348 1.0 0.27259423318903747 0.09553563347364384 22.38542739836004 -12.81106324829109 0.21940744624758726 3.49607200900803 1.651640706941386e-22 0.9994097095048471 0.009508649399502727 7.789980560094874 0.14363818934518643 8.57237134558603 0.09770702712359143 1.545029413455326e-13 12.81106324829109 -3.49607200900803 SSPATADKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSPATADKR 9 1 Q8TF72;A0A2R8Y5P9 Q8TF72 SHROOM3 Protein Shroom3 0 6188600.0 457000.0 3164500.0 2567100.0 False True 599131.4255942948 2692368.935124387 2301481.117362 1.0 4.493786872310617 3.8413627111599067 19.192512982051028 -10.469892201430875 5.881336072902768 0.9975846240043241 4.167574791735262 0.9691635309795327 0.2663510484471012 0.008432955793007912 0.0007600954869379213 0.25781187459173516 0.08596443124004169 3.389282729087137e-11 10.469892201430875 3.1699901677309383 SSPATADKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSPATADKR 9 1 Q8TF72;A0A2R8Y5P9 Q8TF72 SHROOM3 Protein Shroom3 0 3428700.0 457000.0 2971700.0 0.0 False True 625965.249960631 2840400.467902236 0.0 1.0 4.537632828788624 0.0 19.25572304357392 -6.6987971762013565 1.8357398693544735 3.1996320136351915 0.014313440335208361 0.41124737323790217 1.4936675014231229 0.3982464456462309 2.6084639213338696 0.6494008602655786 1.6722115032045695 2.0007960613594416e-07 6.6987971762013565 -3.185318573299983 SSPLIQFHLLHSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSPLIQFHLLHSK 13 0 O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O94973 AP2A2 AP-2 complex subunit alpha-2 0 36243800.0 11687000.0 7063800.0 17493000.0 False True 11316002.582140358 9884412.177230354 12911058.521248873 1.0 0.8734897421135771 1.140955777230551 23.43186107525953 -6.7780922802540635 1.5433915430955338 0.9281890052893221 1.1429458474531358 0.7605506723756692 0.05345777231950358 0.25355062795045324 1.1928413391472847 0.027284715776642657 0.0644815484810721 1.666892988267221e-07 6.7780922802540635 0.21475684216381363 SSPLIQFHLLHSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSPLIQFHLLHSK 13 0 O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O94973 AP2A2 AP-2 complex subunit alpha-2 0 72608000.0 24771000.0 23198000.0 24639000.0 False True 37579418.002674125 19058135.653198745 19769090.85034265 1.0 0.5071429166849413 0.5260616555832742 25.163439387937103 -10.365339588748862 9.026194434742832 1.0000009031009789 0.5166022861477506 0.9988525386492381 0.007723542812976616 1.403623220535245e-07 9.864294593058153e-09 0.0074783022102945015 0.0024927627240315356 4.311817901417299e-11 10.365339588748862 -0.4833986169532283 SSPLIQFHLLHSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSPLIQFHLLHSK 13 0 O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O94973 AP2A2 AP-2 complex subunit alpha-2 0 60307100.0 9705100.0 15471000.0 35131000.0 False True 13293337.740465907 14787440.064244518 26833781.345656417 1.0 1.1123948215977733 2.018588699809559 23.66420005152242 -6.929950622282269 0.7471953865117043 0.9861948604968177 2.2043932918240547 0.996528626116958 0.026866192100067996 0.09266316418018838 0.07780504951262472 0.02446934474734861 0.08201695411929744 1.175031144152266e-07 6.929950622282269 1.2181984313272372 up SSPLIQFHLLHSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSPLIQFHLLHSK 13 0 O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O94973 AP2A2 AP-2 complex subunit alpha-2 0 26560800.0 11687000.0 6747900.0 8125900.0 False True 9718258.321885819 6711547.723346721 9824988.120083453 1.0 0.6906121962442703 1.010982399794547 23.212266350693806 -10.991824195695928 10.832745337087227 1.1216775011969224 0.8507972980191516 0.22432099163504682 0.13079058791496032 0.06909603489859921 5.214890009941222e-05 0.022766094699498828 0.04221248073627655 1.0190038017668874e-11 10.991824195695928 -0.27088020317777084 SSPLIQFHLLHSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSPLIQFHLLHSK 13 0 O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O94973 AP2A2 AP-2 complex subunit alpha-2 0 74944000.0 24771000.0 31307000.0 18866000.0 False True 32066547.8094092 29564737.9289352 15432581.581507023 1.0 0.9219806916745836 0.4812673217345424 24.934565710029553 -6.937124571716697 0.6857902128203751 1.0052783713895903 0.3718421615991097 0.9977625314737899 0.01080259699930838 0.08910321419189988 0.0607685719894971 0.010299152117759303 0.03843642438755821 1.1557806740057457e-07 6.937124571716697 -0.6334362097904807 down SSPPGHYYQK(ub)SK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSPPGHYYQKSK 12 1 D6RDK6;D6RBN5;Q9NX40;D6RI08;D6RDK1;D6RIV2;D6R9T5;D6RG39;D6RIT9;Q9NX40-3;Q9NX40-2;Q9NX40-4 D6RDK6 OCIAD1 OCIA domain-containing protein 1 1 4811100.0 1204700.0 1345200.0 2261200.0 True False 1650110.1457933774 1285764.6160184708 1727151.130875815 1.0 0.7791992669678858 1.0466883894259047 20.654130897726297 -6.687406369810998 1.8751981800768094 0.8612432876800599 1.0457480133716757 0.3585598906233608 0.09343187484178785 0.4222384503302121 2.876478564665561 0.039885930892617806 0.1042232017035055 2.053967796678609e-07 6.687406369810998 0.1845047256916158 SSPPVQFSLLHSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSPPVQFSLLHSK 13 0 O95782;O95782-2 O95782 AP2A1 AP-2 complex subunit alpha-1 0 5920100.0 1690500.0 1868100.0 2361500.0 False True 2216261.870825285 1589386.7617967655 2117154.633107538 1.0 0.7171475459282771 0.955281801748075 21.079696927886335 -10.071650007901722 6.553609506768287 1.000000134968316 0.836214674238093 0.3867785088168926 0.09721790283931847 1.917027312553033e-07 2.718165353562954e-08 0.0941309068083568 0.031376943220824016 8.479104585419685e-11 10.071650007901722 -0.16378546073022304 SSPPVQFSLLHSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSPPVQFSLLHSK 13 0 O95782;O95782-2 O95782 AP2A1 AP-2 complex subunit alpha-1 0 7378600.0 1690500.0 2791600.0 2896500.0 False True 2315523.5340447407 2668257.881413289 2212406.3552900217 1.0 1.152334598280845 0.9554670132958681 21.142906989409227 -6.700104215715251 1.8304691733451475 1.0945841301128996 0.9560510544512735 0.4180747602468624 0.06430112439839479 0.395311574529791 2.5751598499037227 0.028023628618531273 0.07206087839377254 1.994783578187767e-07 6.700104215715251 -0.1385330756616261 SSPVVIDASTAIDAPSNLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSPVVIDASTAIDAPSNLR 19 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1;H0Y4K8 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 11098300.0 1850100.0 5620900.0 3627300.0 False True 2425499.0163938846 4782283.630096588 3251981.791518518 1.0 1.9716699935861686 1.3407475202168535 21.20985016380477 -10.481568896296437 4.922180670952642 0.9981582509174135 1.6562087569015582 0.5905583441472952 0.2575730211684189 0.005218145527354808 0.000549603521894423 0.24998394461091958 0.08313133511811135 3.2993706268018623e-11 10.481568896296437 0.6580505059841447 SSPVVIDASTAIDAPSNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSPVVIDASTAIDAPSNLR 19 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1;H0Y4K8 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 12728500.0 5174500.0 2291400.0 5262600.0 False True 5010238.329878095 3206367.969493142 3884167.185384118 1.0 0.6399631631038911 0.7752459922357875 22.256447801318544 -10.243727162310835 4.7219293187476765 1.000078505852285 0.7076045776689633 0.8616617442391599 0.05522898372524752 4.565708885326115e-05 7.31255832270161e-06 0.05348955124714201 0.017825077849223457 5.705225802579844e-11 10.243727162310835 -0.29247392818332163 SSPVVIDASTAIDAPSNLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSPVVIDASTAIDAPSNLR 19 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1;H0Y4K8 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 10851900.0 1850100.0 4293000.0 4708800.0 False True 2534131.9670725684 4103321.0649474333 3596678.4207801293 1.0 1.619221539471598 1.419294049210474 21.27306022532766 -10.079127206673064 4.590221730259228 0.9999715025539084 1.5192577943018803 0.8999413885062161 0.08162005618716944 56697198.69102684 1.1545588501697435 18449.426678008713 0.027940716188318792 8.334370316667199e-11 10.079127206673064 0.5192862917479719 SSPWNFAFTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSPWNFAFTVK 11 0 Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0-4;Q9H4G0-3;Q9H4G0;Q4VXN0;Q4VXN1;Q4VXN5 Q9H4G0-2 EPB41L1 Band 4.1-like protein 1 0 8715700.0 1697700.0 3697200.0 3320800.0 False True 2225701.140550187 3145592.1715727206 2977195.471362913 1.0 1.4133039311805984 1.3376438629253518 21.08582845490952 -10.1247449688673 4.541973340830335 0.9999641476658868 1.3754738969988378 0.9704466376539326 0.03088809363726902 1.2430036533947347e-05 2.395292325639454e-06 0.029910428035968297 0.009969089337352745 7.503346996943247e-11 10.1247449688673 0.375509749332951 SSPWNFAFTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSPWNFAFTVK 11 0 Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0-4;Q9H4G0-3;Q9H4G0;Q4VXN0;Q4VXN1;Q4VXN5 Q9H4G0-2 EPB41L1 Band 4.1-like protein 1 0 11411500.0 3548400.0 2643400.0 5219700.0 False True 3435757.9842959577 3698923.4051488936 3852503.9823565288 1.0 1.076596029771539 1.121296668730865 21.71219698555811 -13.999917832823963 0.05898907609314263 0.5070727237142169 1.3280498559308755 0.9999567334615174 0.0003294053709604843 12.474564216457717 0.061710091454789597 0.9166675628227365 0.19420549468817508 1.0001892148135422e-14 13.999917832823963 0.8209771322166587 SSPWNFAFTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSPWNFAFTVK 11 0 Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0-4;Q9H4G0-3;Q9H4G0;Q4VXN0;Q4VXN1;Q4VXN5 Q9H4G0-2 EPB41L1 Band 4.1-like protein 1 0 11187700.0 1697700.0 3609100.0 5880900.0 False True 2325385.5686174277 3449638.028302305 4491952.540937365 1.0 1.4834692684333242 1.931702252546481 21.149038516432412 -6.972034211201376 0.2038242787932527 0.7460184502675331 2.681580483188351 0.9999942035417767 0.0009159626223959678 0.07564797568936617 0.00661248690618713 0.014104803370179246 0.04713501036573713 1.0665121042808567e-07 6.972034211201376 1.9355620329208179 SSPWNFAFTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSPWNFAFTVK 11 0 Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0-4;Q9H4G0-3;Q9H4G0;Q4VXN0;Q4VXN1;Q4VXN5 Q9H4G0-2 EPB41L1 Band 4.1-like protein 1 0 23873500.0 7464300.0 8730500.0 7678700.0 False True 9662683.493350014 8244640.00027371 6281255.390115453 1.0 0.8532453749465954 0.6500528962206302 23.20399247524989 -6.966554008375111 0.3303015065095526 1.024668452429562 0.47197509110280755 0.999941681706899 0.0010957151996388486 0.07743755600981714 0.01302191940599944 0.0029617222672275127 0.01771858950655567 1.08005529806336e-07 6.966554008375111 -0.5526933613267544 SSQDEMVSTK(ub)QQNNTSQER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSQDEMVSTKQQNNTSQER 19 1 O43164-2;O43164 O43164-2 PJA2 E3 ubiquitin-protein ligase Praja-2 1 5595300.0 2072800.0 2087800.0 1434700.0 True False 2007000.098593356 2921469.427733166 1058909.0299225831 1.0 1.4556399024497972 0.5276078614369474 20.936609256896723 -6.773223539642986 1.5623487239434446 1.2602661955869288 0.5217691346376806 0.7426602208088644 0.19220487207153678 0.2612463386470887 1.2589511348689146 0.09694925040434638 0.2300817160988148 1.685685147794084e-07 6.773223539642986 -0.7384970609492482 SSQDEMVSTK(ub)QQNNTSQER ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SSQDEMVSTKQQNNTSQER 19 1 O43164-2;O43164 O43164-2 PJA2 E3 ubiquitin-protein ligase Praja-2 1 17113300.0 5422400.0 8998700.0 2692200.0 True False 7019403.691483606 8497914.434506958 2202247.224304739 1.0 1.2106319579278761 0.3137370809683802 22.742917046024964 -6.844822899949633 1.2599051704944164 1.1120794654162072 0.2813255191914611 0.9324134365700482 0.09955283138883925 0.16324568935554445 0.5012806170851808 0.06190569466116318 0.14285039997462975 1.429476763051381e-07 6.844822899949633 -0.8307539462247461 down SSQSSSQQFSGIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSQSSSQQFSGIGR 14 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 13397000.0 1835500.0 5932200.0 5629300.0 False True 2406358.2750072842 5047138.883534491 5046834.0360585535 1.0 2.097417884923729 2.0972912007640576 21.198420026092506 -10.077258679639868 4.427763904894984 0.9999099197068152 2.0973545429260616 0.9999999898796536 5.171887604659508e-05 3799.7251300526873 2882.6324704292088 2.9381841409255847 1.7704704908642886e-05 8.370305715225305e-11 10.077258679639868 1.0974446232192463 SSQSSSQQFSGIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSQSSSQQFSGIGR 14 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 17761600.0 3945700.0 2271900.0 11544000.0 False True 3820445.913266989 3179081.5178019824 8520280.087423377 1.0 0.8321231578654769 2.2301794818860308 21.865309605311452 -6.876909452783958 1.0969413361685048 0.8996649908525051 2.323549858935251 0.9711035445897184 0.10594782970987267 0.1304004571521712 0.2891576957681939 0.07459913829141379 0.17905837800393015 1.3276712385965904e-07 6.876909452783958 1.4238848680827458 up SSQSSSQQFSGIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSQSSSQQFSGIGR 14 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 49872800.0 3654600.0 43009000.0 3209200.0 False True 5544295.387048284 35333707.919149205 2574900.213357675 1.0 6.372984383496285 0.46442334572807115 22.402572692253354 -6.667363428280769 1.9468836552554043 4.43734032648106 0.4886500415617465 0.26734652824846916 2.2837307334518875 0.4672022736255263 3.4115241991911063 0.9452393814704411 2.5340057158006366 2.1509809876956326e-07 6.667363428280769 -3.948690284919313 SSQSSSQQFSGIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSQSSSQQFSGIGR 14 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 14172100.0 1835500.0 5606300.0 6730300.0 False True 2514133.952522405 5358595.128445097 5140741.75487949 1.0 2.1313880762275508 2.0447366178408415 21.261630087615398 -10.113823897459202 4.527326823347307 0.9998946694957536 2.0880623470011876 0.9952658222680274 0.03537530987336886 12328987.99184955 2.9206636267686235 13602.84592127307 0.012109909479710293 7.694423790634855e-11 10.113823897459202 1.088167677505434 SSQSSSQQFSGIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSQSSSQQFSGIGR 14 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 7276000.0 3945700.0 2292200.0 1038100.0 False True 3281024.3741477663 2279851.4636339205 1255161.9103679114 1.0 0.6948596546851632 0.38255183968084205 21.64571488074573 -7.087355700820988 0.2507608895913975 1.104357814567596 2.712626479435576e-13 0.999982461506769 0.0010556605055988095 0.07518905773434359 0.009461439373495178 0.00804011332855537 0.03061297125980978 8.177947142102397e-08 7.087355700820988 -1.1043578145673247 down SSQSSSQQFSGIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSQSSSQQFSGIGR 14 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 11973400.0 3654600.0 4505300.0 3813500.0 False True 4730951.742935974 4254576.094523007 3119482.1298143226 1.0 0.8993065931978131 0.6593772879785089 22.173699014345804 -6.956482602040415 0.4824595006406243 1.0056277723494478 0.5430111646746351 0.9996166752800861 0.002797371638090386 0.0809823907725026 0.025962282446659254 0.003399992711911124 0.01979062580163092 1.1053947509217447e-07 6.956482602040415 -0.4626166076748127 SSQTSGTNEQSSAIVSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSQTSGTNEQSSAIVSAR 18 0 O60763;O60763-2 O60763 USO1 General vesicular transport factor p115 0 3611730.0 434830.0 1467900.0 1709000.0 False True 570066.3408997104 1248895.0418293844 1532169.073885574 1.0 2.1907889524898256 2.6877031039359727 19.120770295675147 -9.707111635646378 0.23489168331504154 1.7776833648343482e-18 3.0242357288319806 0.9991970883152541 0.020065824621127968 1.131238698270919 0.0993942689535728 1.0268195888926437 0.23807504082442443 1.9628556588065253e-10 9.707111635646378 3.0242357288319806 SSQTSGTNEQSSAIVSAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSQTSGTNEQSSAIVSAR 18 0 O60763;O60763-2 O60763 USO1 General vesicular transport factor p115 0 3839030.0 434830.0 1799600.0 1604600.0 False True 595598.4018389096 1720087.721518611 1225626.5277743388 1.0 2.887999222643717 2.057806945066034 19.18398035719804 -10.079875344585544 4.651127772637251 0.9999343355669814 2.4729030838864956 0.8075779803808282 0.3389245782721839 117725357.18694595 15.662830276933105 97543.36694711506 0.11602289797801227 8.320025462737467e-11 10.079875344585544 1.4729687483195142 SSQYIPMHGK(ub)QIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSQYIPMHGKQIR 13 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 22424400.0 7266100.0 7626500.0 7531800.0 True False 9525927.465012498 6488655.927864162 6752481.586127198 1.0 0.6811573940381299 0.7088529291166862 23.183428132694893 -10.07196603115553 5.066062886772527 1.0000060647658995 0.6950051615762665 0.9938536349814423 0.01130665485327004 7.745148748942474e-07 1.4188323031323126e-07 0.010947839050366417 0.0036492071617670397 8.472936836028973e-11 10.07196603115553 -0.305000903189633 SSQYIPMHGK(ub)QIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSQYIPMHGKQIR 13 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 41251000.0 8984700.0 11671900.0 20594400.0 True False 8699485.616476135 16332550.538154416 15200108.821243217 1.0 1.8774156609008998 1.7472422498699713 23.052498669078876 -10.317726000387914 5.478977262331044 0.9998515541013316 1.8123289553854545 0.9811045490773629 0.05314307251729268 9.638159221241996e-05 1.2001983997538914e-05 0.05146477907950646 0.017151852902137686 4.8114280928136705e-11 10.317726000387914 0.8124774012841228 SSQYIPMHGK(ub)QIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSQYIPMHGKQIR 13 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 28504600.0 7266100.0 7660000.0 13578500.0 True False 9952573.52896925 7321555.871767384 10371537.95798569 1.0 0.7356444893832047 1.0420960897999847 23.246638194217784 -6.678521221614023 1.9074251778421096 0.832511358678294 1.0409074097449154 0.31718477302874504 0.11207769771521779 0.44185178863011704 3.1068750874770483 0.04717378082548214 0.12464093401826502 2.0964223370086192e-07 6.678521221614023 0.2083960510666214 SSQYIPMHGK(ub)QIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSQYIPMHGKQIR 13 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 40807900.0 8984700.0 18643700.0 13179500.0 True False 7471176.13969775 18543262.687615305 15935272.514877107 1.0 2.4819737001094824 2.1329001240120373 22.832903944513152 -10.374401655277575 5.841701258347918 0.9997103576235845 2.307436912060762 0.9492501897129759 0.14250869068789637 0.0005376927126361664 5.758220137244354e-05 0.1380118947237778 0.04599448214366946 4.222778918256554e-11 10.374401655277575 1.3077265544371777 SSQYIPMHGK(ub)QIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSQYIPMHGKQIR 13 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 45382900.0 16277700.0 10777200.0 18328000.0 True False 21071803.531436767 10177439.346079808 14992492.061160866 1.0 0.48298852686701493 0.7114954369612335 24.328810463630482 -10.32603142819187 5.79934053705193 1.000049713110333 0.5972419819141238 0.805529763565143 0.09328755540514973 5.996913822811368e-05 6.969433421509792e-06 0.09033639484513172 0.030108429041044774 4.7202888114493405e-11 10.32603142819187 -0.40280773119620916 SSSDECEEITK(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSSDECEEITKSR 13 1 E9PPJ1;Q8NG31-3;Q8NG31-4;Q8NG31-2;Q8NG31 E9PPJ1 CASC5 Protein CASC5 1 3813000.0 1149300.0 0.0 2663700.0 True False 1506743.4298370339 0.0 2388085.87601463 1.0 0.0 1.5849319988559167 20.523002343250635 -6.736184639961596 1.700760148389859 0.40238881226549106 1.5850943824604997 0.5876656922825587 0.42021162470967754 0.3247568925667513 1.8429697969033878 0.1955851465389386 0.4819555656565505 1.8357577064537432e-07 6.736184639961596 1.1827055701950087 SSSDECEEITK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSSDECEEITKSR 13 1 E9PPJ1;Q8NG31-3;Q8NG31-4;Q8NG31-2;Q8NG31 E9PPJ1 CASC5 Protein CASC5 1 3851410.0 852110.0 1437100.0 1562200.0 True False 825060.2344714323 2010941.5243774971 1153012.9550045729 1.0 2.4373269251860012 1.3974894278394603 19.654139923251062 -10.074961470080796 4.844810068212292 0.9999697361432855 1.9174081765223505 0.5092858339114261 0.4245118806851141 0.00013877419713839205 2.649703534604493e-05 0.4110453733605744 0.1370106203419987 8.414697922021239e-11 10.074961470080796 0.917438440379065 SSSDECEEITK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSSDECEEITKSR 13 1 E9PPJ1;Q8NG31-3;Q8NG31-4;Q8NG31-2;Q8NG31 E9PPJ1 CASC5 Protein CASC5 1 4631910.0 852110.0 1616900.0 2162900.0 True False 708567.2198735459 1608189.4387704793 2615152.389880318 1.0 2.269635672755909 3.6907611819059736 19.43454519868534 -6.969666028005775 0.2660423573946937 0.6293319442209987 5.373563802444023 0.9999796593189436 0.004956912898226619 0.07641123838661343 0.009417239384966934 0.02854812658994378 0.13290673506753292 1.0723436193502893e-07 6.969666028005775 4.744231858223024 SSSDECEEITK(ub)SR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSSDECEEITKSR 13 1 E9PPJ1;Q8NG31-3;Q8NG31-4;Q8NG31-2;Q8NG31 E9PPJ1 CASC5 Protein CASC5 1 14591300.0 3684500.0 4776000.0 6130800.0 True False 4769657.882353083 4510211.401558587 5015057.307320225 1.0 0.9456048028613533 1.051450110473348 22.185454357749173 -6.766966828012802 1.5857002607489576 0.9686814353570634 1.0519839476661672 0.7190199833357083 0.022908134403177283 0.271329622953655 1.3458924559147423 0.011389718596586194 0.027192400680276566 1.710145933311124e-07 6.766966828012802 0.0833025123091038 SSSGLLEWESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSSGLLEWESK 11 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 SSSGLLEWESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSSGLLEWESK 11 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 SSSGLLEWESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSSGLLEWESK 11 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 SSSGLLEWESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSSGLLEWESK 11 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 SSSISSFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSSISSFK 8 0 P13796;P13796-2 P13796 LCP1 Plastin-2 0 6998200.0 1932500.0 1108200.0 3957500.0 False True 1871153.845297019 1550710.039186656 2920912.0275448672 1.0 0.82874534506301 1.5610218448292337 20.8354967504162 -6.845085834412867 1.258525279815063 0.9088632053610285 1.5876422793174847 0.9328538407371549 0.0810410967246569 0.16294330907279925 0.49911235638154694 0.050445010736826404 0.11642698077366198 1.4286115783296356e-07 6.845085834412867 0.6787790739564562 SSSISSFK(ub)DPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSSISSFKDPK 11 1 P13796;P13796-2 P13796 LCP1 Plastin-2 1 39815000.0 14917000.0 18782000.0 6116000.0 True False 19556331.456433505 15979798.811662564 5483174.988814608 1.0 0.8171163823471422 0.28037850560212263 24.221132426833268 -6.9519430135150975 0.5370877424588532 1.0080571142096728 0.06477448309360827 0.99934508293183 0.007815440011576068 0.08271475723677599 0.03280484853075223 0.008630895663141163 0.044429442392605586 1.117009807981402e-07 6.9519430135150975 -0.9432826311160646 down SSSISSFK(ub)DPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSSISSFKDPK 11 1 P13796;P13796-2 P13796 LCP1 Plastin-2 1 64080000.0 29049000.0 17770000.0 17261000.0 True False 28126855.39561868 24865653.669325788 12739826.281099692 1.0 0.884053809769261 0.45294172071166455 24.745444931448557 -6.946554889082452 0.5954699479190784 1.004908321061203 0.3101895920724116 0.9989024133041121 0.007797633504842016 0.08489941660780634 0.04192065034683294 0.008039207284691659 0.0361770713026042 1.1309544426068619e-07 6.946554889082452 -0.6947187289887915 down SSSISSFK(ub)DPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSSISSFKDPK 11 1 P13796;P13796-2 P13796 LCP1 Plastin-2 1 82175000.0 25856000.0 26373000.0 29946000.0 True False 39225442.32679917 21666532.096810523 24027159.974201906 1.0 0.5523591529268175 0.6125401920015148 25.225286380087677 -10.336278365672435 5.7376764154743185 1.0000649364976084 0.5824496724643518 0.984659167693963 0.02456880632059082 2.0411647509316728e-05 2.361130963261831e-06 0.023792326387189023 0.007929548142985998 4.6102198289040503e-11 10.336278365672435 -0.41761526403325666 SSSISSFK(ub)DPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSSISSFKDPK 11 1 P13796;P13796-2 P13796 LCP1 Plastin-2 1 33247000.0 14917000.0 10414000.0 7916000.0 True False 20432218.016767506 9953875.045507254 6046403.835137518 1.0 0.4871656634310921 0.29592498622399166 24.28434248835616 -13.999999999999998 0.1369620409288433 3.443954798955199 0.05036307545574117 0.9996153188936522 0.0058303244830243866 11.93212575289999 0.11571885933918967 7.80811988098042 0.21911175940467656 1.0000000000000041e-14 13.999999999999998 -3.393591723499458 SSSISSFK(ub)DPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSSISSFKDPK 11 1 P13796;P13796-2 P13796 LCP1 Plastin-2 1 72584100.0 29049000.0 34683000.0 8852100.0 True False 24155530.588898893 34496155.79496355 10703033.18251402 1.0 1.4280852026002226 0.44308830820850564 24.525850206882833 -6.788586679428125 1.502013923583886 1.239695483246257 0.43302145206322057 0.7967071212940375 0.18182556817168521 0.23746143753826637 1.0583707765662975 0.0952928831767581 0.22333212982373937 1.62709653630811e-07 6.788586679428125 -0.8066740311830365 down SSSISSFK(ub)DPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSSISSFKDPK 11 1 P13796;P13796-2 P13796 LCP1 Plastin-2 1 92441000.0 25856000.0 44451000.0 22134000.0 True False 33471101.69795665 41977262.77443068 18105839.11401868 1.0 1.2541344815367494 0.5409394431472809 24.996412702180127 -6.810358962627327 1.412982898994285 1.138442394448409 0.5283547255266893 0.8607729047538767 0.11012598845812839 0.20631130504297598 0.8117554352428931 0.06128182996212765 0.14173724736017415 1.547536985843062e-07 6.810358962627327 -0.6100876689217197 SSSISSFKDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSSISSFKDPK 11 1 P13796;P13796-2 P13796 LCP1 Plastin-2 0 13283300.0 1171500.0 6002400.0 6109400.0 False True 1535847.844822136 5106865.31717195 5477257.893502938 1.0 3.325111490952001 3.566276380807273 20.550603865856093 -10.184417483050797 0.49900124066401014 6.235456121826369e-15 3.5590120142193307 0.9993934400544682 0.028497747680020225 1.497345743576889 0.2320500462028092 2.176533641253456 0.04896013023865547 6.540071810671319e-11 10.184417483050797 3.5590120142193244 SSSISSFKDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSSISSFKDPK 11 1 P13796;P13796-2 P13796 LCP1 Plastin-2 0 13082800.0 3200000.0 2611100.0 7271700.0 False True 3098417.7515914426 3653725.8467066195 5367023.623676071 1.0 1.1792231195518919 1.7321820535398762 21.563100241378717 -6.95081857138818 0.5497833904591314 0.9923429104169379 1.94502982416408 0.9992639668415969 0.00845428445269771 0.08315870175901244 0.034614823875693465 0.009178634147475486 0.04587075382978809 1.1199056317305656e-07 6.95081857138818 0.9526869137471421 SSSISSFKDPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSSISSFKDPK 11 1 P13796;P13796-2 P13796 LCP1 Plastin-2 0 45697800.0 4481500.0 38208000.0 3008300.0 False True 6798763.141535844 31389483.87953346 2413708.1864152723 1.0 4.6169403501888375 0.3550216614650315 22.696840878646537 -6.6818904278512585 1.895919414721275 3.284630890975514 0.37126971086416904 0.33257925366958274 1.5323189688501087 0.4342698708701824 3.0198288232691226 0.6482538692639537 1.7051282594265078 2.0802214591033916e-07 6.6818904278512585 -2.913361180111345 SSSISSFKDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSSISSFKDPK 11 1 P13796;P13796-2 P13796 LCP1 Plastin-2 0 14539800.0 1171500.0 7838100.0 5530200.0 False True 1604635.2085971094 7491786.824869445 4224080.658044146 1.0 4.668841107767614 2.6324242640401425 20.613813927378985 -10.587187424053784 7.102379662064185 0.9968997416648658 3.650632685903877 0.6931516522779191 0.8313636951235559 0.04075526488242699 0.002368821765156222 0.8038327014222577 0.26832147882124924 2.5870961874061916e-11 10.587187424053784 2.653732944239011 SSSISSFKDPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSSISSFKDPK 11 1 P13796;P13796-2 P13796 LCP1 Plastin-2 0 6444800.0 3200000.0 2171800.0 1073000.0 False True 2660941.7840365064 2160100.0823314507 1297359.3390085432 1.0 0.8117802859462391 0.48755645343000265 21.343505516812993 -6.962856496364151 0.39310982350121515 1.019235520370024 0.2683932842348385 0.999861912431182 0.002487059190920454 0.07869606996697773 0.017473279857900578 0.004179679607091184 0.027237820994267487 1.089289967230698e-07 6.962856496364151 -0.7508422361351856 down SSSISSFKDPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSSISSFKDPK 11 1 P13796;P13796-2 P13796 LCP1 Plastin-2 0 12896300.0 4481500.0 3524800.0 4890000.0 False True 5801390.09357182 3328641.781451781 4000070.175637095 1.0 0.5737662401189076 0.6895020178128235 22.467967200738986 -10.242832547289785 8.093054321006194 1.0000002744618974 0.6316341289658697 0.9310682531017229 0.047248933389046836 2.3393955741385222e-07 2.190076580182692e-08 0.04574861711962193 0.015249527678486837 5.716990265266372e-11 10.242832547289785 -0.36836614549602775 SSSLHYAACFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSSLHYAACFGR 12 0 Q9ULT8;A0A087X2H1;G3V4V5 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 0 4552920.0 1427400.0 956120.0 2169400.0 False True 1871335.2229612623 813470.6229265686 1944931.2983542215 1.0 0.43470064205776343 1.0393281088764514 20.835636589251887 -11.857385545434845 14.170657833632617 0.9137691224709342 0.763312937920432 0.0 0.28295534450146104 0.0 0.0 0.0 0.08215546949934001 1.3887192466877163e-12 11.857385545434845 -0.15045618455050225 SSSLHYAACFGRPQVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSSLHYAACFGRPQVAK 17 1 Q9ULT8;A0A087X2H1;G3V4V5 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 0 9908700.0 2450900.0 4128200.0 3329600.0 False True 3213153.634549365 3512288.651597564 2985084.931778471 1.0 1.0930970165359528 0.9290202932350977 21.615558533172226 -6.752767154724615 1.6394559433376639 1.054558670853463 0.9286210235347789 0.6608591016786282 0.039126652941301264 0.2952391428786167 1.5620893936283962 0.018845742502278776 0.04562288693842543 1.7669849287771187e-07 6.752767154724615 -0.12593764731868418 SSSLHYAACFGRPQVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSSLHYAACFGRPQVAK 17 1 Q9ULT8;A0A087X2H1;G3V4V5 Q9ULT8 HECTD1 E3 ubiquitin-protein ligase HECTD1 0 8578500.0 2450900.0 1996500.0 4131100.0 False True 3357063.963082086 1908288.0284573867 3155419.2626751657 1.0 0.5684395797765519 0.9399342095877755 21.678768594695118 -10.144346325031226 7.560954158674002 1.0000000833771068 0.7541868946821637 0.36859623205332803 0.15166204753693768 2.1322374573627045e-07 2.402063315129265e-08 0.1468461964183656 0.048948715363523125 7.172221195104419e-11 10.144346325031226 -0.24581318869494306 SSSQPSSCCSDPSK(ub)PGGNVEGATQSLAEQMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 SSSQPSSCCSDPSKPGGNVEGATQSLAEQMR 31 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 58697000.0 15627700.0 20862600.0 22206700.0 True False 20488066.038862064 17749981.401777852 19908963.70570791 1.0 0.8663570962778735 0.9717346511839768 24.288280472483358 -10.250847725177405 5.225587442302332 1.0000098509337667 0.9190458737686451 0.44037212013382676 0.04302020664373571 4.937861750478309e-06 7.079225623627366e-07 0.04165920425912887 0.013884711990124277 5.612447283835081e-11 10.250847725177405 -0.0809639771651216 SSSQPSSCCSDPSK(ub)PGGNVEGATQSLAEQMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 SSSQPSSCCSDPSKPGGNVEGATQSLAEQMR 31 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 442043800.0 72305000.0 199557000.0 170181800.0 True False 109691971.20355868 163944494.20404252 136545292.63666737 1.0 1.4945897352852362 1.244806626578678 26.70888269205325 -10.032210412245702 4.331323082547511 0.9999766706292872 1.3696981808886546 0.744952375768524 0.10197352735455374 23501988.42274958 0.15027319502807313 5571.575327525114 0.03490825071505756 9.285164189158034e-11 10.032210412245702 0.3697215102593674 SSSQPSSCCSDPSK(ub)PGGNVEGATQSLAEQMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SSSQPSSCCSDPSKPGGNVEGATQSLAEQMR 31 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 67682900.0 15627700.0 30901600.0 21153600.0 True False 21405683.012712814 29536265.13407403 16157555.35206733 1.0 1.3798328750609112 0.7548254985590217 24.35149053400625 -6.7421779935748996 1.6785222805573599 1.2254210201550868 0.7542662254384105 0.6147954832858866 0.1595840190668318 0.3138742073763913 1.7371437767151245 0.07518511809036467 0.1840725471112981 1.8105978754088928e-07 6.7421779935748996 -0.4711547947166763 SSSQPSSCCSDPSK(ub)PGGNVEGATQSLAEQMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SSSQPSSCCSDPSKPGGNVEGATQSLAEQMR 31 1 Q13501;Q13501-2;E7EMC7 Q13501 SQSTM1 Sequestosome-1 1 414112000.0 72305000.0 222901000.0 118906000.0 True False 93600247.84463008 210496363.40427345 97266328.07858971 1.0 2.248886816557183 1.0391674201551802 26.4800090141457 -6.638678018438151 2.048565664976031 1.817477736668295 1.0441153921490347 0.14982716718353595 0.5345294026179406 0.5366916984661154 4.302724599217672 0.21257233192624506 0.5921408038378313 2.2978516208366462e-07 6.638678018438151 -0.7733623445192603 SSSSGHYVSWVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSSSGHYVSWVK 12 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 29513600.0 8803500.0 11771600.0 8938500.0 False True 11541473.75321526 10015323.165337408 8013629.764146399 1.0 0.8677681359841335 0.6943333178671343 23.46032412049143 -6.967391847726282 0.3143107983742167 1.0253947199216706 0.531159155757429 0.9999542956993241 0.0008461593182862192 0.0771584642338608 0.012045366316636694 0.0026922979859989944 0.015334741516032552 1.0779736678525497e-07 6.967391847726282 -0.49423556416424164 SSSSGHYVSWVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSSSGHYVSWVK 12 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 18913400.0 2813700.0 2665800.0 13433900.0 False True 2724380.633641511 3730267.8419633536 9915158.581638677 1.0 1.3692168399308196 3.639417509874785 21.377496851199897 -6.935319951790644 0.7017603683137986 0.9713261550181085 4.175595268669644 0.9974842503567609 0.05853268796657514 0.08996819893602039 0.06482947198197461 0.055128059230815124 0.1997489180124906 1.1605932709148237e-07 6.935319951790644 3.2042691136515358 up SSSSGHYVSWVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSSSGHYVSWVK 12 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 36770000.0 9150000.0 23435000.0 4185000.0 False True 13881218.95460291 19252841.151509296 3357832.9156493396 1.0 1.3869704969335706 0.24189755428761583 23.72663092539465 -6.815533256606805 1.3909880770227188 1.209569209709813 0.219197233252326 0.8738086764527533 0.16894519737467145 0.19935993313620723 0.7590935764648812 0.09546923422449034 0.2203565559759433 1.5292086409987101e-07 6.815533256606805 -0.990371976457487 down SSSSGHYVSWVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSSSGHYVSWVK 12 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 24078300.0 8803500.0 6743400.0 8531400.0 False True 12058391.855642045 6445454.290558241 6516459.029698352 1.0 0.5345202219102254 0.5404086305794866 23.52353418201432 -10.182556139067707 5.950244897998035 1.0000063263567378 0.5374644262451825 0.9998784607399144 0.0024039327727979707 2.017518538518211e-07 2.7717600299965117e-08 0.002327629720875186 0.0007758659662012135 6.568162076542835e-11 10.182556139067707 -0.46254190011155527 SSSSGHYVSWVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSSSGHYVSWVK 12 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 11074700.0 2813700.0 4417100.0 3843900.0 False True 2339716.2180448477 4393304.205574298 4647641.71781449 1.0 1.8777081475485533 1.9864125751533361 21.157902126634173 -11.003201397223588 0.38196378747624044 1.5335153074908865e-23 1.9981461928752295 0.9994662312585828 0.010202774865712135 2.818064408877112 0.1883931049248323 2.506404585708742 0.02921597687047733 9.926556132682416e-12 11.003201397223588 1.9981461928752295 SSSSGHYVSWVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSSSGHYVSWVK 12 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 28114400.0 9150000.0 9088800.0 9875600.0 False True 11844855.373464718 8583000.2903027 8078342.132213015 1.0 0.72461841193356 0.6820127285226644 23.4977572474871 -13.99999999975483 0.2627095443297752 3.044725134356403 0.6668400795540502 0.9995679098893405 0.0029295959808208864 14.538489898024627 0.16220511212042907 15.807382438745078 0.018364356015045425 1.000000000564523e-14 13.99999999975483 -2.377885054802353 SSSSGHYVSWVK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSSSGHYVSWVKR 13 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 51041500.0 14635700.0 14785200.0 21620600.0 True False 19187544.432320412 12579305.7922582 19383507.71143972 1.0 0.6555974807838891 1.0102130462712686 24.19366675552636 -10.942954657692308 11.194445674499066 1.038403586444621 0.8329052635275789 0.22841818227138788 0.14477119838209873 0.08635676462837641 0.00044006157727196667 0.08723800484799979 0.04672470336202984 1.1403688410096924e-11 10.942954657692308 -0.20549832291704218 SSSSGHYVSWVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSSSGHYVSWVKR 13 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 109377600.0 16664500.0 32719100.0 59994000.0 True False 16135494.569186104 45784007.25785245 44279771.61857912 1.0 2.8374715792899217 2.744246321593392 23.9437344627725 -10.234047887665508 4.74121903775346 0.9995816742056808 2.7908589504471033 0.9979717385423105 0.03805905210136722 0.00016832801502273976 2.719352814451717e-05 0.036858337793895406 0.01228350624410026 5.833807739982794e-11 10.234047887665508 1.7912772762414226 SSSSGHYVSWVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSSSGHYVSWVKR 13 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 51592600.0 14635700.0 15125500.0 21831400.0 True False 20046913.804920822 14457205.396660255 16675272.951796506 1.0 0.7211686316080989 0.83181247318494 24.25687681704925 -10.100894594047881 6.226559034919725 1.0000005635868159 0.7764905525064512 0.8447437839871097 0.04517015917410746 3.533804085662804e-07 5.1025359725901526e-08 0.043735929019632684 0.014578606185570258 7.92693698789875e-11 10.100894594047881 -0.22351001108036472 SSSSGHYVSWVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSSSGHYVSWVKR 13 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 83756700.0 16664500.0 42845800.0 24246400.0 True False 13857270.112523848 42614981.17117452 29316210.137312926 1.0 3.0752796781135254 2.115583365212581 23.724139738206777 -9.649015223602158 6.691351490620144 0.9999999988767376 2.5954315216647266 0.7865489347427947 0.391794379112304 8.201796654069765e-09 1.6895852684934888e-09 0.37935327635723654 0.12645109211907887 2.2438032689335542e-10 9.649015223602158 1.595431522787989 SSSSK(ub)QEQDLLHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSSSKQEQDLLHK 13 1 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 1 12292200.0 3903200.0 4979300.0 3409700.0 True False 5117132.998642574 4236407.849159381 3056896.952151926 1.0 0.8278869926349729 0.5973846982212171 22.286904300031626 -6.967072491606611 0.32049681991323886 1.0313837672097161 0.3864477640994637 0.9999497117803795 0.0011696597485540748 0.0772645447488225 0.012416378256037657 0.003486957108976491 0.020266614123324162 1.0787666415305563e-07 6.967072491606611 -0.6449360031102525 SSSSK(ub)QEQDLLHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSSSKQEQDLLHK 13 1 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 1 11094100.0 3903200.0 4215300.0 2975600.0 True False 5346318.520013873 4029054.1078669718 2272824.5644056597 1.0 0.7536128071652035 0.42511955767269954 22.350114361554517 -6.967141628056972 0.31916604259471415 1.0454296020185534 0.12272037092191294 0.9999507290499262 0.0016529747287320512 0.07724154156395345 0.012335855664801582 0.004996247892353972 0.028916422994306537 1.078594923575741e-07 6.967141628056972 -0.9227092310966405 down SSSSSSQPEHSAMLVSTAASPSLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSSSSSQPEHSAMLVSTAASPSLIK 25 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 0 8855200.0 2130300.0 3805900.0 2919000.0 False True 2792843.929854549 3238074.555282002 2616969.8810251546 1.0 1.1594183694506124 0.9370268968668959 21.413303524282526 -6.7142956812082515 1.779673533346818 1.0975760697160117 0.9374765739922724 0.485470715257625 0.06713531467464534 0.3665609024104782 2.265636958196304 0.029989015982227515 0.07579822930211007 1.930653420482618e-07 6.7142956812082515 -0.16009949572373938 SSSSSSQPEHSAMLVSTAASPSLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSSSSSQPEHSAMLVSTAASPSLIK 25 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 0 8939000.0 2130300.0 3143800.0 3664900.0 False True 2917929.479192856 3004896.5208436395 2799326.1009847764 1.0 1.029804367196304 0.9593535830616143 21.476513585805417 -6.791787904219586 1.489322849282665 1.016619312670654 0.958568571155448 0.8070050650359122 0.01268500619492788 0.23270778323867541 1.0196747775824504 0.006703604628107007 0.015673623002812595 1.6151471513728842e-07 6.791787904219586 -0.05805074151520595 SSTFLSHSISNQANVHQSVISSWLSTDPAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSTFLSHSISNQANVHQSVISSWLSTDPAK 30 0 Q8NFH3;Q8NFH3-2 Q8NFH3 NUP43 Nucleoporin Nup43 0 15898700.0 5662900.0 3349600.0 6886200.0 False True 5483134.339214736 4687112.747933245 5082497.638428167 1.0 0.8548236205725552 0.926932904429997 22.38656939005804 -10.261339361836633 4.9019175737797305 1.0000261250514153 0.890878262501171 0.7532914767603063 0.029438491861740478 8.40707113341954e-06 1.2668707191088944e-06 0.02851051897182338 0.009501232393113027 5.4784870343404455e-11 10.261339361836633 -0.10914786255024433 SSTGPEPPAPTPLLAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSTGPEPPAPTPLLAER 17 0 Q9UQ35;Q9UQ35-2;I3L4D8;I3L1I8;I3L182;Q9UQ35-3 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 6198100.0 1601200.0 1671700.0 2925200.0 False True 1550370.7824525668 2339218.5278003323 2159002.3658810495 1.0 1.5088123139807041 1.3925716288755614 20.564181857104167 -9.998550289118764 4.539798343410278 0.9999875307043615 1.450691971470903 0.9524802725704399 0.047455061132452195 10900341.495861236 0.27111135591573504 1459.455192045805 0.01624512963299891 1.0033436602666605e-10 9.998550289118764 0.4507044407665415 SSTPGLK(ub)SNTPTPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSTPGLKSNTPTPR 14 1 Q04726;A0A0D9SES8;H0YL70;H0YKN8;Q04726-2;Q04726-7;Q04726-6;Q04726-5;Q04726-3;Q04726-4;H0YKT5;H0YLI3;H0YNT2;H0YLW9;H0YKH0 Q04726 TLE3 Transducin-like enhancer protein 3 1 2813880.0 1293900.0 868180.0 651800.0 True False 1772289.7963327372 829820.936912664 497858.26424237416 1.0 0.46821966623615874 0.28091244742962124 20.757183095084144 -13.999999999999998 0.1454237040949538 3.5549985773737345 0.06358667062374143 0.9995822240069115 0.006225632100419394 11.943484166382179 0.11984534617246582 8.636731467461328 0.1950809875011347 1.0000000000000041e-14 13.999999999999998 -3.491411906749993 SSTPLPTISSSAENTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSTPLPTISSSAENTR 16 0 G5E972;P42167;P42167-2;H0YJH7;P42167-3;P42166 G5E972;P42166 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin;Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 0 5830600.0 2336000.0 0.0 3494600.0 False True 2261844.9586617528 0.0 2579259.424247203 1.0 0.0 1.1403343161828616 21.10906861048401 -10.69235948776468 4.43028245272341 1.0186365301150586 0.5701671580997026 0.15926879881180145 0.4655395351391477 0.08628532423098226 0.005991681130838568 0.45386248536606016 0.15025223888289152 2.0306754211114783e-11 10.69235948776468 -0.44846937201535597 SSTPPGESYFGVSSLQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSTPPGESYFGVSSLQLK 18 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 8710200.0 1978300.0 3896100.0 2835800.0 False True 2593570.457884449 3314817.066878852 2542378.618914403 1.0 1.2780902314806273 0.980262021101288 21.306508132339484 -6.661557213520434 1.9670242060436116 1.1787677207129437 0.9814906350631736 0.24241972811059165 0.11835943629053688 0.4807406006638225 3.5772337406963812 0.048582467614121716 0.13125938559832528 2.1799311963143034e-07 6.661557213520434 -0.1972770856497701 SSTPPGESYFGVSSLQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSTPPGESYFGVSSLQLK 18 0 Q9UQ35;Q9UQ35-2 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 9027300.0 1978300.0 3240700.0 3808300.0 False True 2709730.9715473 3097515.158438193 2908857.97440048 1.0 1.143108002588708 1.0734858939666159 21.369718193862376 -10.520980072181024 6.265578931295457 0.9998920359822717 1.1082969482776617 0.7633747941744201 0.02842310682345846 4.290869497271417e-05 3.280478958629887e-06 0.02754792511735325 0.00917351828122741 3.0131442806427215e-11 10.520980072181024 0.10840491229538995 SSTQMTWGALFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSTQMTWGALFR 12 0 Q9HAV4;H0Y9I3 Q9HAV4 XPO5 Exportin-5 0 11818400.0 2880700.0 3620200.0 5317500.0 False True 3776625.596738481 3080080.271429072 4767296.109061756 1.0 0.815564104127518 1.2623163157022568 21.84866633575987 -6.794580078544595 1.477823756570789 0.8975293357343186 1.26769687407495 0.8158737108675918 0.07865703690725823 0.22858741355391812 0.986040511605898 0.041882581057389456 0.097747384532801 1.6047963261703733e-07 6.794580078544595 0.3701675383406313 SSTQMTWGALFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSTQMTWGALFR 12 0 Q9HAV4;H0Y9I3 Q9HAV4 XPO5 Exportin-5 0 4554900.0 0.0 1027400.0 3527500.0 False True 0.0 1437646.177820222 2603541.927268358 0.0 SSTQMTWGALFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSTQMTWGALFR 12 0 Q9HAV4;H0Y9I3 Q9HAV4 XPO5 Exportin-5 0 10172400.0 2880700.0 3186400.0 4105300.0 False True 3945772.6379903513 3045614.3119842787 3135712.6913074804 1.0 0.7718676648169626 0.7947018186290004 21.91187639728276 -9.981731335487195 5.387760320092715 1.000000707460149 0.7832847417224511 0.9917424502678794 0.009322004259814226 7.921646676505893e-08 1.4953278971338157e-08 0.00902602126644639 0.0030086639373587856 1.0429624303120901e-10 9.981731335487195 -0.2167159657376978 SSTQMTWGALFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSTQMTWGALFR 12 0 Q9HAV4;H0Y9I3 Q9HAV4 XPO5 Exportin-5 0 4123200.0 0.0 1440400.0 2682800.0 False True 0.0 1432640.279302987 3243761.076134316 0.0 SSVGAPVEVTHNFQVDFVWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSVGAPVEVTHNFQVDFVWK 20 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 37286000.0 11962000.0 13835000.0 11489000.0 False True 18147228.5393399 11366036.156651622 9218194.114192415 1.0 0.6263235254910752 0.5079670482029276 24.113245899603236 -13.999999999999998 0.1609007734153525 2.843851203574119 0.3927654825045581 0.9995340267246396 0.004526507113339655 12.015775913194469 0.12679080247257488 6.913845284290379 0.1051155856420059 1.0000000000000041e-14 13.999999999999998 -2.4510857210695605 SSVGAPVEVTHNFQVDFVWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSVGAPVEVTHNFQVDFVWK 20 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 32522400.0 11962000.0 12042000.0 8518400.0 False True 15485044.806271588 11371852.114231268 6968138.606165033 1.0 0.734376442335224 0.4499915042766212 23.884372221695685 -6.970257035256095 0.251970916497403 1.088090239332815 0.0879274898032791 0.9999843181573207 0.0008893390723497602 0.07621939412533531 0.008731204490981907 0.006259070092569491 0.027168701037827505 1.070885318935563e-07 6.970257035256095 -1.0001627495295358 down SSVLIAQQTDTSDPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSVLIAQQTDTSDPEK 16 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 13798100.0 2930600.0 4056400.0 6811100.0 False True 3842044.9799707723 3451200.9317233567 6106352.708684633 1.0 0.8982718707654513 1.5893496147281143 21.873442978489226 -6.8694761696685775 1.1368058815358297 0.9426395225249806 1.629431562696032 0.9641605502757017 0.057673041956100055 0.13736114370799435 0.33209471163260246 0.0393834817196049 0.0931621593279234 1.3505909345911974e-07 6.8694761696685775 0.6867920401710514 SSVLIAQQTDTSDPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSVLIAQQTDTSDPEK 16 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 10712200.0 3273700.0 1189200.0 6249300.0 False True 3169778.185432778 1664053.7615960746 4612420.855018617 1.0 0.5249748292304803 1.4551241712166905 21.59595045638516 -6.767907441813996 1.5827568182078393 0.7268075116480756 1.459911241345797 0.7223880050025452 0.20009180554863187 0.2698256430105548 1.3337263176078302 0.09967241992998904 0.237691866228815 1.7064460333187004e-07 6.767907441813996 0.7331037296977215 SSVLIAQQTDTSDPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSVLIAQQTDTSDPEK 16 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 9415200.0 2930600.0 2356500.0 4128100.0 False True 4014122.016487151 2252382.038096585 3153127.800888226 1.0 0.5611144924955956 0.7855087084890358 21.936653040012118 -10.071600758529582 4.853087476723775 1.0000101983739025 0.6733116004888986 0.7386351740768267 0.09160855508108798 1.0108858035028193e-05 1.9337891644234166e-06 0.0887023699317888 0.029566534014919894 8.480066177779251e-11 10.071600758529582 -0.3266985978850039 SSVLIAQQTDTSDPEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSVLIAQQTDTSDPEK 16 0 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 0 6631300.0 3273700.0 1683000.0 1674600.0 False True 2722226.599500093 1673933.3449506562 2024751.1175244239 1.0 0.6149133012138136 0.7437849288138787 21.376355731819437 -10.33271907556677 4.912330526257511 1.0001690939184336 0.6793491150137145 0.8919440640381996 0.052611621657477264 9.748240374815333e-05 1.3241897884417874e-05 0.05096765810726591 0.01698032787463298 4.64815845250781e-11 10.33271907556677 -0.320819978904719 SSVLQVSVLQSTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSVLQVSVLQSTK 13 0 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 0 11189100.0 3665000.0 2733300.0 4790800.0 False True 4804850.491910487 2325502.2943199547 4295093.972598598 1.0 0.48399056291870113 0.8939079332083023 22.196060110014134 -9.917933976476924 6.725443398778058 1.0000000164231875 0.6889492480634992 0.43430280172680913 0.16734806565218804 4.114262334772762e-08 6.821174542203996e-09 0.16203407506620712 0.05401135594091013 1.2079974666972922e-10 9.917933976476924 -0.31105076835968826 SSVLQVSVLQSTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSVLQVSVLQSTK 13 0 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 0 9842900.0 3342200.0 2665500.0 3835200.0 False True 3236103.6904277867 3729848.050398874 2830646.066466222 1.0 1.1525737143193389 0.8747080864062281 21.62582640430755 -6.757603090122285 1.6213042523113053 1.0888852527738502 0.8738045691436469 0.6811967584965217 0.06415303577367573 0.28695444521128066 1.486048524980108 0.031227354107642883 0.07522857637803405 1.7474184218700727e-07 6.757603090122285 -0.21508068363020327 SSVLQVSVLQSTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSVLQVSVLQSTK 13 0 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 0 14532200.0 3665000.0 3639100.0 7228100.0 False True 5020049.542900909 3478312.529105574 5520971.647392304 1.0 0.6928841039077834 1.0997842949976007 22.259270171537025 -6.704795182788574 1.8135849021199346 0.8101982323311939 1.0986963996214183 0.4404353111376128 0.12952719423458117 0.38563509186550377 2.4690639214109313 0.05690526354641041 0.1454952876960736 1.97335316792584e-07 6.704795182788574 0.28849816729022437 SSVLQVSVLQSTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSVLQVSVLQSTK 13 0 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 0 7149400.0 3342200.0 2334600.0 1472600.0 False True 2779187.3845646284 2322023.04641818 1780513.8514668983 1.0 0.8355043129925315 0.6406598782635966 21.406231679741826 -6.968884463935889 0.28357169996702314 1.0411205353205486 0.4290772063129298 0.999972323096632 0.0007726670621153005 0.07666638286195726 0.010320002084687661 0.0035265564674690636 0.017805046702327392 1.07427516549132e-07 6.968884463935889 -0.6120433290076188 SSVLQVSVLQSTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSVLQVSVLQSTK 13 0 Q6L8Q7;Q6L8Q7-2;F6T1Q0 Q6L8Q7 PDE12 2,5-phosphodiesterase 12 0 20258000.0 7217300.0 10652000.0 2388700.0 False True 9342937.124252124 10059206.836139468 1953981.110131763 1.0 1.0766642975716996 0.2091399186514566 23.15544472830353 -6.885354477455408 1.0494535694962397 1.0519350450321163 0.14097231475230032 0.9777552356250527 0.05848582138169049 0.12299414369883563 0.24450421896809824 0.042700455448992154 0.10482159604505263 1.3021035487965418e-07 6.885354477455408 -0.910962730279816 down SSVNCPFSSQDMK(ub)YPSPFFVFGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSVNCPFSSQDMKYPSPFFVFGEK 24 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 1 9089700.0 3924100.0 2384400.0 2781200.0 True False 3263063.017105513 2371554.7639336535 3362736.0611841213 1.0 0.726787914147405 1.0305458532538618 21.637795418717705 -6.669732338523922 1.9385906685547338 0.8255642089603614 1.0293083662449487 0.2777038265984536 0.11606276357630792 0.46175890314274015 3.3454224160757895 0.04820577944737708 0.12882611922113266 2.1392801501533274e-07 6.669732338523922 0.20374415728458728 SSWVMTCAYAPSGNFVACGGLDNICSIYSLK(ub)TR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSWVMTCAYAPSGNFVACGGLDNICSIYSLKTR 33 1 P62879;E7EP32;C9JIS1;C9JXA5;C9JZN1 P62879 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 82286700.0 5415700.0 15894000.0 60977000.0 True False 8216012.84070414 13057591.519611206 48924869.222831465 1.0 1.5892856757624207 5.954818982322627 22.970007005752155 -6.931555286594733 0.7339133052557745 0.9372951260324097 6.887601012752103 0.9968351742258993 0.1243253290421208 0.09183833215169948 0.07378263146951344 0.11433257644895571 0.39168213646574523 1.1706975605888769e-07 6.931555286594733 5.9503058867196925 up SSWVMTCAYAPSGNYVACGGLDNICSIYNLK(ub)TR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 33 1 P62873;P62873-2;F6UT28;F6X3N5;Q9HAV0;H7C5J5 P62873;Q9HAV0 GNB1;GNB4 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein subunit beta-4 1 152977000.0 18027000.0 31380000.0 103570000.0 True False 27348276.950232428 25779993.826940972 83099344.10365637 1.0 0.9426551396219451 3.0385586724486537 24.704946604590905 -6.900609472822134 0.9574023581128703 0.9143112848269518 3.261305985668214 0.9868672281039084 0.11170851003567171 0.11095819546624174 0.17489855479659758 0.08740807271896739 0.22812533413994057 1.2571599215092998e-07 6.900609472822134 2.346994700841262 up SSWVMTCAYAPSGNYVACGGLDNICSIYNLK(ub)TR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSWVMTCAYAPSGNYVACGGLDNICSIYNLKTR 33 1 P62873;P62873-2;F6UT28;F6X3N5;Q9HAV0;H7C5J5 P62873;Q9HAV0 GNB1;GNB4 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;Guanine nucleotide-binding protein subunit beta-4 1 97832000.0 18027000.0 16994000.0 62811000.0 True False 23336306.865294922 16048268.961073402 51380042.49528459 1.0 0.6876953175885736 2.201721240291689 24.476072926683354 -6.852928583526942 1.2209122748857193 0.8328325190257678 2.2657398584047024 0.9444542818854399 0.1538249717285072 0.15426564359037234 0.4410413067320616 0.0985102916356678 0.22842168780633149 1.403044405731369e-07 6.852928583526942 1.4329073393789344 up SSYYK(ub)SLLSAEEAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SSYYKSLLSAEEAAK 15 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 41177900.0 13736500.0 14712900.0 12728500.0 True False 18008684.52445523 12517792.67043502 11411476.920393527 1.0 0.6950975599265038 0.6336652132973454 24.102189465147102 -13.999999999999998 0.2252139721633404 2.88310131567497 0.6024028074099409 0.999503643705772 0.0035688237104673746 13.146729274481125 0.15029820183219084 11.041107681783567 0.032866141468533554 1.0000000000000041e-14 13.999999999999998 -2.2806985082650293 SSYYK(ub)SLLSAEEAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SSYYKSLLSAEEAAK 15 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 59498900.0 15709300.0 16267600.0 27522000.0 True False 15210616.870336076 22763337.514413323 20313162.55769804 1.0 1.496542691756746 1.3354594840471599 23.858575327315254 -9.979421462424392 4.645389203526843 0.9999927534523303 1.4160010879306508 0.8989139985835898 0.06576194427846521 22614750.54883145 0.04442429700823904 1826.9883785129148 0.022512062675419952 1.0485243910121938e-10 9.979421462424392 0.41600833447832053 SSYYK(ub)SLLSAEEAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SSYYKSLLSAEEAAK 15 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 74510400.0 16281000.0 20176400.0 38053000.0 True False 24699467.300534423 16575763.781067278 30531807.870777614 1.0 0.6710980273128655 1.2361322412049347 24.557976591399438 -6.748853519402245 1.6537029652462094 0.8063483683487994 1.2371880002012958 0.6442609192151763 0.13819978601272648 0.3020076706282695 1.6245554593368805 0.06602205061908352 0.16050128828393556 1.7829800367545865e-07 6.748853519402245 0.4308396318524964 SSYYK(ub)SLLSAEEAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SSYYKSLLSAEEAAK 15 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 40968400.0 13736500.0 12339300.0 14892600.0 True False 18815255.264954526 11794108.925391551 11375274.602724714 1.0 0.6268375719227881 0.6045772136779036 24.165399526669994 -13.999999999999996 0.4011897383271613 7.338597178862138 0.603306996233586 0.9998394434682509 0.00229833940105605 26.94641528632434 0.2088897832151835 148.74900230059947 0.005677267270869369 1.0000000000000082e-14 13.999999999999996 -6.735290182628551 SSYYK(ub)SLLSAEEAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SSYYKSLLSAEEAAK 15 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 59367100.0 15709300.0 28874200.0 14783600.0 True False 13062978.989988966 28718648.95352007 17874782.408356693 1.0 2.1984762415624406 1.3683542185940385 23.63898060274953 -10.196390641076912 4.770118160781474 0.9998850048699718 1.7834152300813395 0.5428601525753254 0.33889589676391824 0.00041451523612358223 6.98320947613377e-05 0.32818216763389524 0.1093781803538763 6.362229908510592e-11 10.196390641076912 0.7835302252113677 SSYYK(ub)SLLSAEEAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SSYYKSLLSAEEAAK 15 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 86251800.0 16281000.0 20864800.0 49106000.0 True False 21076075.446489517 19703655.538366728 40169211.870109394 1.0 0.9348825680754819 1.9059151677500792 24.329102913491887 -6.89085882158351 1.0173242988853095 0.948894167471305 1.9908406153223206 0.9814410464570116 0.06037753137743535 0.11844768453780716 0.21781712174386517 0.045170800825499825 0.11296145012640449 1.285704542830395e-07 6.89085882158351 1.0419464478510156 STAAPLTMTMCLPDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STAAPLTMTMCLPDLK 16 0 Q9H488 Q9H488 POFUT1 GDP-fucose protein O-fucosyltransferase 1 0 3508950.0 925300.0 1686400.0 897250.0 False True 1213077.2606179477 1434795.693535714 804411.177029744 1.0 1.182773546348418 0.6631161947755685 20.210240007631526 -6.8116564878617085 1.4075244671038385 1.0994165826942084 0.6536733268241075 0.8641175377632401 0.07934097947827155 0.2045497790724813 0.7983659482765445 0.04431906679939662 0.10244597479799833 1.5429203678723696e-07 6.8116564878617085 -0.4457432558701009 STAAPLTMTMCLPDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STAAPLTMTMCLPDLK 16 0 Q9H488 Q9H488 POFUT1 GDP-fucose protein O-fucosyltransferase 1 0 4881500.0 925300.0 2101100.0 1855100.0 False True 1267408.4152922824 2008266.454591441 1416963.5869837804 1.0 1.5845456210958693 1.1180007721954477 20.273450069154418 -9.924188670405108 9.59436028141965 1.00002159028039 1.3512731966390499 0.4304788489660888 0.19046613739621324 0.0 0.0 0.1844180443536904 0.061472681451230124 1.1907246095588783e-10 9.924188670405108 0.35125160635865993 STACQMLVCYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STACQMLVCYAK 12 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 11200000.0 3696000.0 3122100.0 4381900.0 False True 4845491.792114915 2656294.849850485 3928503.0221528346 1.0 0.548199225963623 0.8107542414055268 22.208211668409017 -10.229983815185246 5.605931232340842 1.000015459725555 0.6794767336845635 0.6652258583520541 0.10718763620691164 2.0711775926514625e-05 2.8447581178203763e-06 0.1037889844800427 0.034594660829053006 5.888656001498774e-11 10.229983815185246 -0.32053872604099154 STACQMLVCYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STACQMLVCYAK 12 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 10292700.0 3696000.0 2639200.0 3957500.0 False True 5062511.080644409 2522591.4173326967 3022820.007270931 1.0 0.4982885720442897 0.5970989414380017 22.27142172993191 -10.173039876589089 5.786159874721172 1.0000074217933057 0.5476937567411914 0.9654436331360253 0.04033916438513504 3.862176239535961e-06 5.52040026533949e-07 0.03905886837876933 0.013019409321955413 6.713672056694801e-11 10.173039876589089 -0.45231366505211434 STACQMLVCYAK(ub)ELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STACQMLVCYAKELK 15 1 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 1 16433100.0 2928800.0 9917400.0 3586900.0 True False 3839685.1625395427 8437762.57772243 3215761.9959743563 1.0 2.1975141764336086 0.8375066860553412 21.87255659041014 -6.674169577874119 1.9223117794561606 1.7615892341234907 0.8428539466873567 0.29780324151111626 0.5081903263479034 0.4515922269568443 3.2209784238226815 0.21251640666538082 0.5647793614673016 2.1175341455703938e-07 6.674169577874119 -0.918735287436134 STACQMLVCYAK(ub)ELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STACQMLVCYAKELK 15 1 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 1 12962400.0 2928800.0 4287700.0 5745900.0 True False 4011656.507843975 4098255.236472197 4388836.760525099 1.0 1.0215867755524173 1.0940210738241485 21.935766651933033 -6.94891018973033 0.5706874464189645 0.9991004664810939 1.1200332157440807 0.9991129057857343 0.0011976503572139535 0.08392644274043194 0.03779711889004294 0.0012678448319598866 0.006036216081311126 1.1248375615871058e-07 6.94891018973033 0.1209327492629868 STAGDTHLGGEDFDNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STAGDTHLGGEDFDNR 16 0 P11142;E9PKE3;P11142-2;P54652;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 168229710.0 488210.0 97843500.0 69898000.0 False True 640048.0378323654 83245631.19097582 62665625.46896069 1.0 130.06153643233046 97.907690930807 19.287820662895875 -9.881323672151133 6.779502296736263 0.9999972698376708 113.98461368157095 0.9427363846801194 13.126752457844244 0.0005851217908444336 9.475913297854462e-05 12.709923387107402 4.2366411382503015 1.3142449830949975e-10 9.881323672151133 112.98461641173328 STAGDTHLGGEDFDNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STAGDTHLGGEDFDNR 16 0 P11142;E9PKE3;P11142-2;P54652;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 176529100.0 42446500.0 23247700.0 110834900.0 False True 41099059.09153946 32530627.845153905 81803914.71427236 1.0 0.7915175812832799 1.9904084551442274 25.292602029906615 -6.862050986887456 1.17541298732803 0.8862215958893765 2.0507571267800078 0.9560803375765305 0.10960414146482822 0.14469900084411905 0.37873181612277074 0.07266880193220085 0.17003193310925876 1.3738806696905494e-07 6.862050986887456 1.1645355308906313 STAGDTHLGGEDFDNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STAGDTHLGGEDFDNR 16 0 P11142;E9PKE3;P11142-2;P54652;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 698483100.0 25991100.0 653066000.0 19426000.0 False True 39430398.90393214 536521269.8720523 15586442.585281737 1.0 13.606792849832125 0.39529000513680834 25.23280496998604 -6.65680297295922 1.9842981734078722 9.136154647773017 0.4507313883676575 0.22205845132650337 5.371825233393228 0.49208864745983866 3.721257146895323 2.189791587138197 5.952822801450291 2.2039260948009422e-07 6.65680297295922 -8.68542325940536 STAGDTHLGGEDFDNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STAGDTHLGGEDFDNR 16 0 P11142;E9PKE3;P11142-2;P54652;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 138953910.0 488210.0 71015100.0 67450600.0 False True 668714.4303791684 67877418.06646836 51520157.46871228 1.0 101.50434173819328 77.04358561471417 19.351030724418766 -9.355585292303276 8.493445060451148 1.000000375186847 89.27396369940338 0.9455473470213064 9.986061870974265 0.0 0.0 9.668957211003653 3.2229876100234884 4.4097575016047113e-10 9.355585292303276 88.27396332421654 STAGDTHLGGEDFDNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STAGDTHLGGEDFDNR 16 0 P11142;E9PKE3;P11142-2;P54652;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 60125400.0 42446500.0 12454000.0 5224900.0 False True 35296145.448783025 12386907.83007455 6317402.432791932 1.0 0.35094222535003855 0.17898278558373715 25.07300730534089 -13.99999999999943 0.1864475775713512 4.437714080695705 0.05110882461662441 0.9994917604717776 0.007970265063633256 12.2950159771617 0.13692285376520189 15.338119956331406 0.12168731439027454 1.000000000001313e-14 13.99999999999943 -4.386605256079081 STAGDTHLGGEDFDNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STAGDTHLGGEDFDNR 16 0 P11142;E9PKE3;P11142-2;P54652;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 74562100.0 25991100.0 23182000.0 25389000.0 False True 33645991.31117577 21891901.321384247 20768462.513139084 1.0 0.6506540740296953 0.6172640990441165 25.00393129207849 -13.999999999999998 0.3320491935479791 4.850164855580276 0.6114916834618914 0.999719078854552 0.0029011198567622212 18.997487302926352 0.18437446874266195 51.1348263131523 0.010618581304570935 1.0000000000000041e-14 13.999999999999998 -4.238673172118385 STALK(ub)ILAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STALKILAGK 10 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 12993000.0 2364800.0 4307400.0 6320800.0 True False 3100275.700755777 3664752.7101136977 5666784.249394931 1.0 1.1820731650479712 1.8278323595586992 21.56396508625175 -6.947640864507948 0.5841801245826175 0.9923958002524903 2.049679586596368 0.9990028222785899 0.011216342741695109 0.08444731956541156 0.03999285138675523 0.011699331911009983 0.05400662944790861 1.1281299663860182e-07 6.947640864507948 1.057283786343878 STALK(ub)ILAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STALKILAGK 10 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 23034200.0 3626200.0 4895000.0 14513000.0 True False 3511088.265881529 6849599.027087773 10711609.91933258 1.0 1.9508478592371827 3.0507948271825107 21.74348683416971 -6.969214998428944 0.27629214402158225 0.7465997355179893 4.28839197215369 0.9999755960948429 0.004139597231746879 0.07655824907506914 0.009938367892586498 0.020761271448850104 0.10144262818470488 1.0734578631272032e-07 6.969214998428944 3.5417922366357004 STALK(ub)ILAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STALKILAGK 10 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 9895600.0 2364800.0 3493800.0 4037000.0 True False 3239130.4663170725 3339432.3635484134 3083543.7446248312 1.0 1.0309656860921028 0.9519665159183461 21.62717514777464 -6.800418064446701 1.4545207785809848 1.0170761296931798 0.9508686693889229 0.8332899968896376 0.013270287531388305 0.22016661290945222 0.9195928513849653 0.00717773597195693 0.016686180026866792 1.583368262459622e-07 6.800418064446701 -0.06620746030425695 STALK(ub)ILAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STALKILAGK 10 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 14745200.0 3626200.0 6668400.0 4450600.0 True False 3015345.96789787 6632476.005626233 5381199.8827506285 1.0 2.1995738055391447 1.7846044666317673 21.523892109603985 -10.066881754767797 4.74844568526674 0.9999639803577791 1.992089136104657 0.8840032654293905 0.16941052326652392 117537686.66837548 3.736459692515543 47275.22461714776 0.05799372816045905 8.572712224444135e-11 10.066881754767797 0.992125155746878 STAYEDYYYHPPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STAYEDYYYHPPPR 14 0 O43390;O43390-3;B4DT28;A0A286YEZ8;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 16972200.0 6552700.0 2762300.0 7657200.0 False True 6344688.125266644 3865300.795204203 5651549.608923962 1.0 0.6092184074125406 0.8907529412545314 22.597117819097495 -10.392031453103831 5.360739778646532 1.0001376587179927 0.7499856743335317 0.5125494317438095 0.11493599214754868 0.00018920122986984983 2.145761065269083e-05 0.11134724736040794 0.03709543195560466 4.0547916818550124e-11 10.392031453103831 -0.25015198438446096 STAYEDYYYHPPPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STAYEDYYYHPPPR 14 0 O43390;O43390-3;B4DT28;A0A286YEZ8;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 42567000.0 6862900.0 29778000.0 5926100.0 False True 10411521.045196105 24463883.243424095 4754803.737498099 1.0 2.349693492163835 0.4566867527672121 23.311677515179372 -6.715255706939669 1.7759164500108655 1.8253036350783187 0.4603217276704037 0.49005059865900613 0.5683194617184751 0.36472286093343453 2.2452549165482933 0.2543285111821098 0.6421634875231155 1.926390345646132e-07 6.715255706939669 -1.364981907407915 STAYEDYYYHPPPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STAYEDYYYHPPPR 14 0 O43390;O43390-3;B4DT28;A0A286YEZ8;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 16926400.0 6862900.0 4076900.0 5986600.0 False True 8884159.337983722 3850016.9311168757 4897100.227703275 1.0 0.4333574832068067 0.5512170641476453 23.082803837271822 -10.742131806927048 6.118817188954505 1.0134205315478606 0.492287273677226 0.9611538600770626 0.04811597243388463 0.008729560372496047 0.000367893673331102 0.046167783331924915 0.015529363326917518 1.8107904403546664e-11 10.742131806927048 -0.5211332578706346 STCGK(ub)CGYPAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STCGKCGYPAK 11 1 P61927;D6RG19;D6R9X9 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 1 12512050.0 664340.0 922110.0 10925600.0 True False 870956.1734777109 784534.7823566284 9795123.717755556 1.0 0.900774121875727 11.246402535553333 19.732240598660304 -6.904733876507248 0.9308445808375985 0.623930215001798 12.443130502582775 0.9887781466331723 0.5141742817664757 0.10800446083324519 0.15841554272598457 0.41029475717581626 1.0952570977084906 1.2452774491620932e-07 6.904733876507248 11.819200287580978 up STCGK(ub)CGYPAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STCGKCGYPAK 11 1 P61927;D6RG19;D6R9X9 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 1 3431360.0 2407260.0 736810.0 287290.0 True False 2330842.8489675066 1031022.0754133901 212040.13048474156 1.0 0.4423387341922695 0.09097144004310243 21.152420307099355 -8.362868327513766 0.38546250958724276 1.0947743205955838 6.858542963433835e-18 0.997285140904368 0.01950166455170728 0.13622010166212317 0.10755996321585085 0.08253681781318002 0.08296900527577962 4.336423332219805e-09 8.362868327513766 -1.0947743205955838 STCGK(ub)CGYPAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STCGKCGYPAK 11 1 P61927;D6RG19;D6R9X9 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 1 1595390.0 315530.0 889290.0 390570.0 True False 478682.07833288005 730589.2514455159 313373.66830708773 1.0 1.526251523746116 0.6546592874303615 18.86870826757558 -6.743290983151612 1.675256697310181 1.3119292812402525 0.6538342319762838 0.6193732803392928 0.2210973870061023 0.311890770834702 1.72000430694969 0.10436946875010825 0.2551335935832248 1.80596370055486e-07 6.743290983151612 -0.6580950492639688 STCGK(ub)CGYPAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STCGKCGYPAK 11 1 P61927;D6RG19;D6R9X9 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 1 14711630.0 664340.0 745990.0 13301300.0 True False 909964.4511134479 713029.6951409598 10159806.888872497 1.0 0.783579725854658 11.165059114606933 19.795450660183196 -6.902138384037419 0.9476327700884053 0.5933434369704615 12.303429041462735 0.987601169599302 0.5393429887840174 0.10984836251122361 0.168667327168141 0.4250795966999602 1.118357759424761 1.2527419363674092e-07 6.902138384037419 11.710085604492274 up STCGK(ub)CGYPAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 STCGKCGYPAKR 12 2 P61927;D6RG19;D6R9X9 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 2 8618100.0 1348500.0 2007600.0 5262000.0 True False 1767896.5588925742 1708073.905563509 4717538.7166681625 1.0 0.9661616778265927 2.668447253284587 20.75360243322856 -6.902365463547643 0.9461869405993113 0.9337451454510043 2.855972379065681 0.9877070049109489 0.08810135196507655 0.10968517551930745 0.1677602233719006 0.0695110955094274 0.18310095637639942 1.252087086538021e-07 6.902365463547643 1.9222272336146768 up STCGK(ub)CGYPAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STCGKCGYPAKR 12 2 P61927;D6RG19;D6R9X9 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 2 10860500.0 1348500.0 1946100.0 7565900.0 True False 1847076.8918422556 1860114.8671078961 5778990.244601682 1.0 1.0070587073679627 3.128722074389538 20.816812494751453 -6.907628836959048 0.9117282869388595 0.9292819257111485 3.3894493298924333 0.9899956334833013 0.10020483003969273 0.10600701871858312 0.1474262265512643 0.08108911310004005 0.22033115538162787 1.2370041682396647e-07 6.907628836959048 2.4601674041812847 up STCHLQK(ub)VEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STCHLQKVEIK 11 1 A0A0G2JPH3;A0A0G2JNK3;Q8WX94-2;Q8WX94-3;A0A0G2JNK1;A0A0G2JMB6;Q8WX94;A0A0G2JM25;K7ERG0 A0A0G2JPH3 NLRP7 NACHT, LRR and PYD domains-containing protein 7 1 4977000.0 1394500.0 1371800.0 2210700.0 True False 1828203.0043572118 1167132.78723452 1981957.9705317991 1.0 0.6384043700031435 1.0841016921031956 20.801994846021273 -6.690947992877223 1.8636085060268188 0.7734982746521736 1.0825560165931403 0.37466208946188273 0.15290077395425056 0.4146063899728062 2.7926737736266336 0.06562596164361367 0.17065530418772457 2.03728602978282e-07 6.690947992877223 0.3090577419409667 STCHLQK(ub)VEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STCHLQKVEIK 11 1 A0A0G2JPH3;A0A0G2JNK3;Q8WX94-2;Q8WX94-3;A0A0G2JNK1;A0A0G2JMB6;Q8WX94;A0A0G2JM25;K7ERG0 A0A0G2JPH3 NLRP7 NACHT, LRR and PYD domains-containing protein 7 1 7008600.0 1394500.0 1111400.0 4502700.0 True False 1910084.334945518 1062294.6730916807 3439254.996017391 1.0 0.556150665002957 1.8005775625166256 20.865204907544165 -6.8102776035893475 1.4134314920354445 0.7581839984053124 1.822472023436818 0.860527097981125 0.1923121198336068 0.20642833055299692 0.8127639692605113 0.10698467434193197 0.24743897757667316 1.5478269225559853e-07 6.8102776035893475 1.0642880250315057 STCHLQK(ub)VEIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STCHLQKVEIK 11 1 A0A0G2JPH3;A0A0G2JNK3;Q8WX94-2;Q8WX94-3;A0A0G2JNK1;A0A0G2JMB6;Q8WX94;A0A0G2JM25;K7ERG0 A0A0G2JPH3 NLRP7 NACHT, LRR and PYD domains-containing protein 7 1 24412100.0 2942300.0 6406800.0 15063000.0 True False 3808865.351403853 6050255.947970168 12321688.559431791 1.0 1.5884667452841812 3.235002401670703 21.86092985688531 -6.953006249880852 0.524802327979832 0.9730238115793154 3.9245302081305673 0.9994165813130647 0.022847421409436793 0.08230055496092135 0.03113660299085213 0.02568972969588634 0.13607390066275998 1.1142784980254284e-07 6.953006249880852 2.951506396551252 STCIYGGAPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STCIYGGAPK 10 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QRQ7 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 17351500.0 2101200.0 8428300.0 6822000.0 False True 2754693.548049742 7170830.49325608 6116124.881244811 1.0 2.6031318432254866 2.220256001098519 21.39346040126031 -10.050081437727853 5.568818009024006 0.9999927586979181 2.4116939221626295 0.9477153712267146 0.15630840801045517 1.4052604967196418e-05 2.3974592378015453e-06 0.15134574198407844 0.05044832175773644 8.910838288342752e-11 10.050081437727853 1.4117011634647114 STCIYGGAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STCIYGGAPK 10 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QRQ7 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 13213500.0 5176000.0 2707800.0 5329700.0 False True 5011690.713199157 3789038.660990452 3933691.6824272624 1.0 0.7560400028300551 0.7849031210300353 22.2568659535965 -9.803517582560303 6.142777778098644 1.0000000102591386 0.7704715620385139 0.988279273068033 0.011783318663380232 1.6474607851995876e-09 3.3211604204857035e-10 0.011409149746265855 0.0038030497454124585 1.5721081438398423e-10 9.803517582560303 -0.2295284482206248 STCIYGGAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STCIYGGAPK 10 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QRQ7 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 56169500.0 7719000.0 42230000.0 6220500.0 False True 11710287.334489597 34693726.55550405 4991015.44845799 1.0 2.962670817933111 0.426207769792143 23.48127313979084 -6.700091253481889 1.8303030245073577 2.2186242103041396 0.4336844964572371 0.418082960021824 0.8284540860449633 0.39535339601598446 2.5749051864196684 0.36107194607912657 0.9285603090993201 1.9948431166742025e-07 6.700091253481889 -1.7849397138469025 STCIYGGAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STCIYGGAPK 10 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QRQ7 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 18003900.0 2101200.0 7322900.0 8579800.0 False True 2878070.4227949185 6999350.064408003 6553427.946527643 1.0 2.431959276941832 2.2770214010828664 21.4566704627832 -10.18482887192469 4.58425212354956 0.9997517861963251 2.354490339027981 0.990281853085533 0.06325312300085524 22199720.172328696 27.083098939643584 58164.46489177934 0.02165322642966237 6.533879609326443e-11 10.18482887192469 1.3547385528316558 STCIYGGAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STCIYGGAPK 10 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QRQ7 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 8290300.0 5176000.0 1385400.0 1728900.0 False True 4304073.335679049 1377936.5752196317 2090404.9964695906 1.0 0.3201470950313713 0.48568061773970445 22.037271229030775 -10.471031442775633 9.265120002854715 1.0000075003206816 0.4029138563887884 0.9454971254003934 0.06757877766013806 1.047009522891089e-05 5.977564467014016e-07 0.06543369037934295 0.021810956702897375 3.3804036131059794e-11 10.471031442775633 -0.5970936439318932 STCIYGGAPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STCIYGGAPK 10 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QRQ7 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 0 19656400.0 7719000.0 6251900.0 5685500.0 False True 9992397.66423761 5903976.26913821 4650797.338156377 1.0 0.5908468084960534 0.4654335720446149 23.25239946188329 -13.999999999999998 0.16562569559786586 3.040817817516003 0.34949096519912837 0.9995227130028896 0.004986623240359844 12.051970650648848 0.12877702461959883 7.900185067946053 0.10646842923729098 1.0000000000000041e-14 13.999999999999998 -2.6913268523168745 STCIYGGAPK(ub)GPQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STCIYGGAPKGPQIR 15 1 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2;J3KTA4;P17844;P17844-2;J3KRZ1;J3QRQ7 A0A1X7SBZ2;J3KTA4 DDX17;DDX5 Probable ATP-dependent RNA helicase DDX17;Probable ATP-dependent RNA helicase DDX5 1 36354300.0 5890000.0 3842300.0 26622000.0 True False 8935560.6166788 3156611.5449730754 21360150.031162888 1.0 0.35326396186950554 2.3904655731720728 23.091126816053706 -6.821327094029638 1.3660826364256755 0.6518630185074833 2.436229128701286 0.8874034715325075 0.2852067496943408 0.19177276304550647 0.7028496731147562 0.16404422331770868 0.37797572598054185 1.508943247612801e-07 6.821327094029638 1.7843661101938029 up STDQTVLEELASIK(ub)NR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STDQTVLEELASIKNR 16 1 Q96S59;Q96S59-2;Q96S59-3 Q96S59 RANBP9 Ran-binding protein 9 1 35923800.0 7590600.0 6376200.0 21957000.0 True False 11515495.147192227 5238317.292522021 17617189.32590503 1.0 0.454892926927181 1.5298681559690077 23.45707311016997 -6.768848405653617 1.57882625819034 0.6868800206098596 1.5356573439696217 0.7261412882541981 0.22966808936908997 0.268300149929979 1.3197000986833323 0.11467220059921343 0.27326077423855794 1.7027527656505105e-07 6.768848405653617 0.8487773233597621 STDVAK(ub)TFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STDVAKTFR 9 1 P13796;Q5TBN3 P13796 LCP1 Plastin-2 1 8024400.0 2254200.0 3733500.0 2036700.0 True False 2955278.0297038495 3176476.353069015 1825961.8214059377 1.0 1.0748485662404264 0.6178646486228975 21.494862433468523 -6.864867899774674 1.1608280549992402 1.041269378880356 0.5935794548116456 0.9592912164709034 0.040378833987258334 0.14187456741633056 0.36054444294058835 0.02707037453149801 0.06358139124416874 1.3649982677163049e-07 6.864867899774674 -0.44768992406871033 STDVAK(ub)TFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STDVAKTFR 9 1 P13796;Q5TBN3 P13796 LCP1 Plastin-2 1 12046400.0 3789300.0 3627700.0 4629400.0 True False 3669010.7456579506 5076259.528205578 3416821.2609769357 1.0 1.3835499212459434 0.9312649915295381 21.80695969922672 -6.681993639106553 1.8947034801795322 1.2422424537734882 0.9329560235923652 0.33327153484929906 0.16248754667713303 0.4341361927831815 3.0148852693452572 0.06876887427011477 0.18091802185231404 2.0797271476010264e-07 6.681993639106553 -0.309286430181123 STDVAK(ub)TFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STDVAKTFR 9 1 P13796;Q5TBN3 P13796 LCP1 Plastin-2 1 15482900.0 4936400.0 4722000.0 5824500.0 True False 7488879.699180522 3879322.206845607 4673285.022030959 1.0 0.518011019361161 0.6240299229993423 22.836318483826307 -10.698485873653421 6.00300543023358 1.006644244715092 0.5710204711803494 0.9561971664510838 0.04328203616714056 0.003875677041339397 0.00019466415517578682 0.042200448312169674 0.013969217105440213 2.0022307473197338e-11 10.698485873653421 -0.4356237735347427 STDVAK(ub)TFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STDVAKTFR 9 1 P13796;Q5TBN3 P13796 LCP1 Plastin-2 1 7156500.0 2254200.0 2077500.0 2824800.0 True False 3087638.6574644516 1985709.1806262047 2157640.4185821675 1.0 0.6431157920068458 0.6987995222063995 21.558072494991414 -10.434136017702109 5.995129549143012 1.0001332980842366 0.6709576571066458 0.9789726324562708 0.02273278766061916 4.0518305756992845e-05 3.824407604336563e-06 0.022019768803459003 0.007336975668537242 3.680136965232334e-11 10.434136017702109 -0.3291756409775908 STDVAK(ub)TFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STDVAKTFR 9 1 P13796;Q5TBN3 P13796 LCP1 Plastin-2 1 12281100.0 3789300.0 5885700.0 2606100.0 True False 3150970.8444529767 5853992.565880022 3151023.46075505 1.0 1.8578377442576124 1.0000166984414236 21.587364974660996 -10.286786171443776 4.070187690229059 0.999472301440365 1.4289272213542523 0.2500145990108925 0.35020397560046557 117040539.56306107 518.2140705860471 588338.3159462212 0.12636897472095926 5.1667069383743034e-11 10.286786171443776 0.4294549199138873 STDVAK(ub)TFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STDVAKTFR 9 1 P13796;Q5TBN3 P13796 LCP1 Plastin-2 1 19291100.0 4936400.0 5881900.0 8472800.0 True False 6390267.110991389 5554567.094394355 6930837.338269516 1.0 0.8692229914521706 1.084592743603524 22.607444805918757 -6.742338770729985 1.6781755608131366 0.9223996827666955 1.084783519355381 0.6153819488215979 0.05494487434276831 0.31359910235108923 1.7350068122070406 0.025892258248310703 0.0633738654900895 1.809927710553901e-07 6.742338770729985 0.1623838365886855 STELLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STELLIR 7 0 Q71DI3;Q16695;P68431;Q6NXT2;Q5TEC6;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 Q71DI3;Q5TEC6;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;HIST2H3PS2;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 0 154113000.0 32668000.0 56379000.0 65066000.0 False True 42828064.35736204 47967472.96362071 58333594.477143876 1.0 1.1200009545931118 1.3620413472437607 25.35205313935926 -6.9598791076366755 0.43713494195185487 0.9910825507904226 1.5003517941700426 0.9997656861535511 0.002304904164001867 0.07974435040947496 0.021291161417944415 0.0031801736526226995 0.020065790873723406 1.0967834597308012e-07 6.9598791076366755 0.50926924337962 STELLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STELLIR 7 0 Q71DI3;Q16695;P68431;Q6NXT2;Q5TEC6;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 Q71DI3;Q5TEC6;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;HIST2H3PS2;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 0 158775000.0 48795000.0 13607000.0 96373000.0 False True 47246029.43403258 19040346.059567615 71130020.17197269 1.0 0.40300415268023226 1.5055237662095649 25.49368975425364 -6.759643005064009 1.6137937855750768 0.6530799187154197 1.509484134505883 0.6895258779276162 0.25108517483770465 0.2835130342490484 1.4551565836758722 0.12276363820514381 0.2951268348261035 1.739229907804098e-07 6.759643005064009 0.8564042157904632 STELLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STELLIR 7 0 Q71DI3;Q16695;P68431;Q6NXT2;Q5TEC6;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 Q71DI3;Q5TEC6;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;HIST2H3PS2;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 0 879751000.0 86301000.0 662780000.0 130670000.0 False True 130924926.44821708 544501730.676225 104843017.22530454 1.0 4.158885137060468 0.8007872913854311 26.9641645534006 -6.659920877050151 1.9726428790652675 3.033417657891417 0.8146429849394015 0.23544886874792526 1.344997474574393 0.484656541504444 3.6252223369469045 0.5508045768372116 1.491476467722467 2.1881602426977367e-07 6.659920877050151 -2.2187746729520157 STELLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STELLIR 7 0 Q71DI3;Q16695;P68431;Q6NXT2;Q5TEC6;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 Q71DI3;Q5TEC6;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;HIST2H3PS2;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 0 458858000.0 32668000.0 169780000.0 256410000.0 False True 44746242.419505306 162278558.2126194 195851238.92971334 1.0 3.6266410191770797 4.376931521837462 25.41526320088215 -9.5305858123323 0.36790975918861424 4.45071146029057e-19 4.5257297456298495 0.9984070531336092 0.057785320116427306 0.8795694179870335 0.1512824088659723 1.3293657589101726 0.20765613011509268 2.947231075100831e-10 9.5305858123323 4.5257297456298495 STELLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STELLIR 7 0 Q71DI3;Q16695;P68431;Q6NXT2;Q5TEC6;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 Q71DI3;Q5TEC6;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;HIST2H3PS2;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 0 155876000.0 48795000.0 72905000.0 34176000.0 False True 40575204.485019125 72512246.29449055 41322043.58802982 1.0 1.7871073532423718 1.0184062930178561 25.274095029687917 -10.338669538733722 5.092866835671228 0.9998274261718788 1.4027568231301721 0.2679484521897263 0.3138208937146197 0.000615184001578217 7.98837120850395e-05 0.3039847047985598 0.1012852579206918 4.5849062649714e-11 10.338669538733722 0.40292939695829333 STELLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STELLIR 7 0 Q71DI3;Q16695;P68431;Q6NXT2;Q5TEC6;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 Q71DI3;Q5TEC6;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;HIST2H3PS2;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 0 344881000.0 86301000.0 143630000.0 114950000.0 False True 111718345.74703597 135636864.23908284 94030279.48660192 1.0 1.2140966045648904 0.8416726801479395 26.73529087549305 -6.750882827912127 1.647328605267973 1.1257630133124494 0.8409165292404492 0.6524529665882259 0.08996753337238404 0.2985095432928883 1.594195877215394 0.04314474809079983 0.10461600560167356 1.7746682194893445e-07 6.750882827912127 -0.2848464840720002 STEPELIQVK(ub)SELPLDPLPVPTEEGNPLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STEPELIQVKSELPLDPLPVPTEEGNPLLK 30 1 Q15758;M0QXM4;Q15758-3;Q15758-2 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 1 166975000.0 60180000.0 22832000.0 83963000.0 True False 58269618.84086655 31948936.667307097 61970571.46399246 1.0 0.5482949314386141 1.063514275479185 25.79624053782469 -6.6751023498961475 1.9190004554352285 0.7129514906509213 1.061495902212708 0.30187952188328027 0.1916523928710708 0.4495593061841833 3.1962900492364046 0.08025881329004196 0.2130371450205096 2.1129910139456935e-07 6.6751023498961475 0.3485444115617866 STEPELIQVK(ub)SELPLDPLPVPTEEGNPLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STEPELIQVKSELPLDPLPVPTEEGNPLLK 30 1 Q15758;M0QXM4;Q15758-3;Q15758-2 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 1 183402000.0 33959000.0 74604000.0 74839000.0 True False 51518285.73544916 61290333.316287555 60047038.84690108 1.0 1.1896811479911948 1.1655480765654316 25.61858125296467 -10.030929582316903 4.301054087319117 0.9999884136933946 1.1776146123168327 0.9863429412408904 0.009852285290495533 3405571.0743444827 0.026438542150035924 406.8510479163076 0.0033726992900574957 9.312588600598188e-11 10.030929582316903 0.1776261986234381 STEPELIQVK(ub)SELPLDPLPVPTEEGNPLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STEPELIQVKSELPLDPLPVPTEEGNPLLK 30 1 Q15758;M0QXM4;Q15758-3;Q15758-2 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 1 132095000.0 60180000.0 39310000.0 32605000.0 True False 50042336.42603654 39098229.22757589 39422554.7515131 1.0 0.7813030329901516 0.7877840558020375 25.576645813258967 -10.420307655813964 5.886271328107059 1.0000833936699411 0.7845435443960944 0.9993218327938358 0.0026458664834102135 2.896748346735846e-06 2.8527740236170734e-07 0.0025628375009903053 0.0008539497355446094 3.7992016412272656e-11 10.420307655813964 -0.21553984927384673 STEPELIQVK(ub)SELPLDPLPVPTEEGNPLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STEPELIQVKSELPLDPLPVPTEEGNPLLK 30 1 Q15758;M0QXM4;Q15758-3;Q15758-2 Q15758 SLC1A5 Neutral amino acid transporter B(0);Amino acid transporter 1 141070000.0 33959000.0 62544000.0 44567000.0 True False 43960594.931965895 59063371.419405386 36456263.2960365 1.0 1.3435525954735776 0.8292941292641007 25.38970757505712 -6.72664410477249 1.7352633044857602 1.2075172054620957 0.829772229204394 0.5436971740185765 0.14446384737931517 0.3425823955603341 2.019291004279644 0.06601353033397384 0.16444683822773662 1.8765316565217215e-07 6.72664410477249 -0.37774497625770176 STESDVK(ub)ADGDSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STESDVKADGDSK 13 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3;Q9Y4W2-4 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 7140600.0 1402800.0 1243400.0 4494400.0 True False 2128150.1584171527 1021505.5552714585 3606079.8700345047 1.0 0.4799969359451686 1.6944668381466967 21.021168517701334 -6.790368736281299 1.4949534342007733 0.7095059542668501 1.7074962884951292 0.8024748693445569 0.2211112902234225 0.2348107356751657 1.0367185391368599 0.116418013893919 0.27247899609262943 1.6204336893052284e-07 6.790368736281299 0.9979903342282791 STESDVK(ub)ADGDSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STESDVKADGDSK 13 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3;Q9Y4W2-4 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 11158020.0 1402800.0 814520.0 8940700.0 True False 1815952.2533219995 769191.2459793757 7313584.339328951 1.0 0.4235745981604203 4.027410041178063 20.792294839793783 -6.865937637854082 1.1552845328670716 0.6807399075317846 4.222867323153045 0.9604624928413795 0.31429022440849325 0.14081412095714493 0.3538061189655451 0.21159899030263835 0.4977580674412332 1.3616401919912513e-07 6.865937637854082 3.54212741562126 up STESLQANVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STESLQANVQR 11 0 P26373;J3QSB4 P26373 RPL13 60S ribosomal protein L13 0 49631400.0 8091400.0 19238000.0 22302000.0 False True 10607903.757229073 16367765.389136655 19994402.97589003 1.0 1.5429783078473305 1.8848590101757141 23.338636255634572 -8.887809696577245 0.1154692868929256 7.486316901432778e-20 2.7550930756096164 0.999943926696281 0.002728237953225351 0.3923453254733877 0.03553292531161881 0.465127687835628 0.33816862741544085 1.2947630691660977e-09 8.887809696577245 2.7550930756096164 STESLQANVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STESLQANVQR 11 0 P26373;J3QSB4 P26373 RPL13 60S ribosomal protein L13 0 51284600.0 12503000.0 6667600.0 32114000.0 False True 12106099.108796181 9330007.451074662 23702380.000650875 1.0 0.7706865248026562 1.9578874902344838 23.529230731307646 -6.856649498130388 1.2026847953998427 0.876539835368929 2.0117657436160163 0.9494164043992207 0.11564681578159668 0.15029831356032333 0.41504367022875616 0.0750963242897434 0.1746728145282772 1.3910748597042954e-07 6.856649498130388 1.1352259082470875 STESLQANVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STESLQANVQR 11 0 P26373;J3QSB4 P26373 RPL13 60S ribosomal protein L13 0 115610300.0 9812400.0 98012000.0 7785900.0 False True 14886128.182529546 80520992.8287487 6247013.452318805 1.0 5.409129347901803 0.4196533427443101 23.827465228190057 -6.673439940002304 1.9248684227643507 3.8059891680256994 0.43937823738698306 0.2944024624927878 1.8714379493344184 0.4533319698975513 3.2413099784176502 0.7817420923753439 2.0795309457750046 2.1210947058998838e-07 6.673439940002304 -3.3666109306387164 STESLQANVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STESLQANVQR 11 0 P26373;J3QSB4 P26373 RPL13 60S ribosomal protein L13 0 42479400.0 8091400.0 16378000.0 18010000.0 False True 11083009.24186315 15654365.80519661 13756408.92759304 1.0 1.4124652847952488 1.2412160476806087 23.401846317157464 -10.171023208583245 5.246551665616396 0.9999853759884636 1.326840666238084 0.8292594055524881 0.06991220829583564 1.1959566800294698e-05 1.8895862036638086e-06 0.06769523067847315 0.02256406820211801 6.744919820601202e-11 10.171023208583245 0.32685529024962046 STESLQANVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STESLQANVQR 11 0 P26373;J3QSB4 P26373 RPL13 60S ribosomal protein L13 0 25557800.0 12503000.0 8688500.0 4366300.0 False True 10396798.476815132 8641693.325967787 5279273.1425097985 1.0 0.8311879224396596 0.5077787315280354 23.309636006741922 -6.960877760931253 0.42288753740026774 1.013858627861516 0.3128503788844317 0.9998013659593982 0.0028783003461317277 0.0793891339794172 0.019984242310275274 0.004191845144737922 0.026900323693285873 1.0942643209761046e-07 6.960877760931253 -0.7010082489770844 STESLQANVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STESLQANVQR 11 0 P26373;J3QSB4 P26373 RPL13 60S ribosomal protein L13 0 36072400.0 9812400.0 12571000.0 13689000.0 False True 12702345.231320765 11871412.79920289 11197742.46100125 1.0 0.9345843293513227 0.8815492145017799 23.598591550282507 -6.973513692748011 0.1524835541917441 1.059550330143023 0.7551854167687403 0.9999984212895762 6.059551328140814e-05 0.07517848902859729 0.004671992820063183 0.0026407429969978412 0.006550179365255815 1.0628850713443001e-07 6.973513692748011 -0.3043649133742826 STFSFSMTKPSEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STFSFSMTKPSEK 13 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 57712000.0 14540000.0 14902000.0 28270000.0 False True 19062080.805560283 12678679.68754104 25344891.584988434 1.0 0.6651256920410679 1.329597321694046 24.184202275799915 -6.769683825008695 1.5755754996604154 0.8078463232366473 1.3332971977492531 0.729368666529304 0.1411219020647805 0.26694822337268764 1.3077645723355613 0.07060075865593851 0.16811394050192632 1.6994804576576314e-07 6.769683825008695 0.5254508745126059 STFSFSMTKPSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STFSFSMTKPSEK 13 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 14268900.0 0.0 4513400.0 9755500.0 False True 0.0 4489085.418360244 11795329.94566435 0.0 STFSVEIVPICK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STFSVEIVPICK 12 0 C9JA08;Q96D46 C9JA08 NMD3 60S ribosomal export protein NMD3 0 7087100.0 1761400.0 2220400.0 3105300.0 False True 2309212.4574218667 1889124.9750514124 2783993.344140944 1.0 0.8180819261474696 1.2056029470970155 21.13896948265635 -6.779063763671913 1.5396419888030777 0.8968677007045724 1.2085762975465448 0.7640191726753799 0.07690033244617629 0.2520334644198896 1.1800265278530173 0.03934282635935243 0.09290068650195978 1.663168443922763e-07 6.779063763671913 0.3117085968419724 STFSVEIVPICK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STFSVEIVPICK 12 0 C9JA08;Q96D46 C9JA08 NMD3 60S ribosomal export protein NMD3 0 12400000.0 0.0 6640200.0 5759800.0 False True 0.0 5455204.429880605 4621373.00538998 0.0 STFSVEIVPICK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STFSVEIVPICK 12 0 C9JA08;Q96D46 C9JA08 NMD3 60S ribosomal export protein NMD3 0 6702800.0 1761400.0 1950600.0 2990800.0 False True 2412637.180045203 1864416.0422283872 2284434.6374594844 1.0 0.7727709983286652 0.9468620712446633 21.20217954417924 -10.557943585932527 5.129795255806381 1.0007568989372988 0.859816534786663 0.46367137722450225 0.07107238290298026 0.0006185073231938719 5.329934066634886e-05 0.06918163750920683 0.02293851294654264 2.767301089470355e-11 10.557943585932527 -0.14094036415063582 STFSVEIVPICK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STFSVEIVPICK 12 0 C9JA08;Q96D46 C9JA08 NMD3 60S ribosomal export protein NMD3 0 8579800.0 0.0 5112600.0 3467200.0 False True 0.0 4828079.315663407 2836205.1764762616 0.0 STFVLDEFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STFVLDEFK 9 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 37398500.0 4622500.0 16232000.0 16544000.0 False True 6060142.264353681 13810248.871840421 14832185.581253914 1.0 2.278865457181358 2.44749791906672 22.53092023128452 -10.594050187064616 0.40393791645634564 2.64084704225914e-13 2.46115468455085 0.9993538318129886 0.016428514519854356 2.1023115694643693 0.19263873839021795 2.164826198173092 0.042517039970471945 2.5465359579192275e-11 10.594050187064616 2.4611546845505856 STFVLDEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STFVLDEFK 9 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 23801600.0 8361200.0 4168400.0 11272000.0 False True 8095778.2826894885 5832863.857918834 8319525.047248464 1.0 0.7204821641905323 1.0276374619889719 22.948738349123637 -6.667167937212148 1.947202389219674 0.8211551503011408 1.0263876268942973 0.2666544570118303 0.11881060001943097 0.4676514057372401 3.4156146563515395 0.04916682364883771 0.13185854247754397 2.1519494370863003e-07 6.667167937212148 0.20523247659315647 STFVLDEFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STFVLDEFK 9 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 49295500.0 3939300.0 41588000.0 3768200.0 False True 5976206.101406255 34166296.471472904 3023413.618339269 1.0 5.717054581406298 0.5059085257497784 22.51079847252988 -6.668331831390886 1.9427477148597976 4.015272848051194 0.5269401349556591 0.271670655409602 2.004498145499685 0.4651102523245221 3.382563877325258 0.8310053458598822 2.225515376604453 2.146190008065279e-07 6.668331831390886 -3.4883327130955353 STFVLDEFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STFVLDEFK 9 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 30863500.0 4622500.0 14065000.0 12176000.0 False True 6331563.168365474 13443561.793264786 9300279.572591508 1.0 2.123261102476738 1.4688757460493636 22.59413029280741 -10.296565777311066 5.498647253730624 0.9998921117739507 1.7960684242629879 0.663662706172022 0.2671517030661379 0.0003534170417416654 4.521158718876938e-05 0.25870309099979355 0.08622284140716394 5.051661277671446e-11 10.296565777311066 0.7961763124890372 STFVLDEFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STFVLDEFK 9 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 15904100.0 8361200.0 4074800.0 3468100.0 False True 6952708.263964386 4052848.243615524 4193263.675317366 1.0 0.5829164822895385 0.603112271666983 22.729143624557913 -10.301629223245973 7.055357628906807 1.000004811968839 0.5930143769782766 0.9981565826043693 0.008244896487909954 6.240721021556591e-07 6.176168247391974e-08 0.007983181100746818 0.0026610288990732717 4.993105894754115e-11 10.301629223245973 -0.4069904349905623 STFVLDEFKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STFVLDEFKR 10 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 61546700.0 10427000.0 25079600.0 26040100.0 False True 13669897.975211646 21337821.439515103 23345720.246277217 1.0 1.5609349446651402 1.7078196405423987 23.704499139693514 -11.446514580174625 0.23881227312283138 1.9098793033107786e-13 1.7835802955169722 0.9993060096050421 0.008034858130817616 3.870616320644714 0.1346726608504497 2.082210555483724 0.07184558371248954 3.5767239256417374e-12 11.446514580174625 1.7835802955167812 STFVLDEFKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STFVLDEFKR 10 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 60147200.0 19850900.0 10308300.0 29988000.0 False True 19220744.045333307 14424457.947074352 22133243.179283787 1.0 0.7504630368654501 1.1515289484674043 24.196160848904665 -6.738436490434273 1.692326002502905 0.8512589035768797 1.1516891092504407 0.5979388437632602 0.10484944231879807 0.3206548413772262 1.8025485274678457 0.049024431812806024 0.12051304261943556 1.8262637953884174e-07 6.738436490434273 0.30043020567356093 STFVLDEFKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STFVLDEFKR 10 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 272094900.0 25102600.0 238778000.0 8214300.0 False True 38082479.4458814 196166200.3189708 6590740.004544416 1.0 5.151087932647361 0.1730648870673047 25.18262407583606 -6.685486430279191 1.8828552855642335 3.613578302491952 0.19145904122362578 0.34905627525238536 1.7572938896141905 0.4265417544997955 2.9282270224844957 0.747701556856207 1.957928442762604 2.0630681277685606e-07 6.685486430279191 -3.422119261268326 STFVLDEFKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STFVLDEFKR 10 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 86203900.0 10427000.0 31071900.0 44705000.0 False True 14282143.679079892 29699040.716967233 34146599.72837577 1.0 2.079452593693593 2.390859558316362 23.767709201216405 -10.34544019457166 0.27542615220140376 2.01948312378939e-16 2.5204612197821006 0.999061178530992 0.018260807669987656 1.8810988678902423 0.13170560111473745 1.47479431843586 0.12418426856008895 4.513981817902072e-11 10.34544019457166 2.5204612197821006 STFVLDEFKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STFVLDEFKR 10 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 33276800.0 19850900.0 11280200.0 2145700.0 False True 16506902.89397822 11219431.323655613 2594355.949404133 1.0 0.6796811852421148 0.1571679415616217 23.97656612433894 -7.344765700184921 0.493805836836581 1.0128116380831167 1.7028288391228343e-24 0.9983458235143359 0.014128061150444531 0.10502038102590243 0.051537755245573406 0.0159101326685595 0.059108603526178485 4.520997842851131e-08 7.344765700184921 -1.0128116380831167 down STFVLDEFKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STFVLDEFKR 10 1 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 81120500.0 25102600.0 32146600.0 23871300.0 False True 32495810.546222426 30357613.450867515 19526968.340222042 1.0 0.9342008382184062 0.6009072557967634 24.95375039792851 -6.939516638518415 0.6640501570458943 1.0037740839668972 0.5122938669006749 0.9980998257575129 0.007615459186330961 0.08798801734251441 0.055620186679438716 0.007386169302692857 0.028747586889704572 1.1494322059842241e-07 6.939516638518415 -0.49148021706622225 STGEAFVQFASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STGEAFVQFASK 12 0 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 70128000.0 19615000.0 21724000.0 28789000.0 False True 25715454.951930206 18482863.87948877 25810190.443587936 1.0 0.7187453581528583 1.003683990496564 24.616132341957417 -10.968138248254672 10.345766924891542 1.0649694651447 0.8612146743247184 0.24030484163064325 0.11632570954142901 0.07579849443541038 0.00023343560604402238 0.04897479140341496 0.03754396131580962 1.0761225987475647e-11 10.968138248254672 -0.2037547908199815 STGEAFVQFASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STGEAFVQFASK 12 0 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 64079000.0 17090000.0 13342000.0 33647000.0 False True 16547487.304593023 18669530.177610837 24833841.311636716 1.0 1.1282395830833365 1.5007620706706137 23.98010882816749 -6.952172586980871 0.5344601412201202 0.9943065879796726 1.65173571672271 0.9993609362736579 0.005369124283829127 0.08262489225497299 0.03244129122072707 0.005951413180260567 0.030824321869082523 1.1164194987374104e-07 6.952172586980871 0.6574291287430374 STGEAFVQFASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STGEAFVQFASK 12 0 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 88422000.0 16311000.0 53397000.0 18714000.0 False True 24744979.49382822 43867888.15733473 15015169.697362432 1.0 1.772799535690707 0.6067966110502313 24.560632510855143 -6.727999472754487 1.7305207439287456 1.4660973825654882 0.6077379095273027 0.5499841636929944 0.32492038647792065 0.3399930733491694 1.9937689916085328 0.148848321635547 0.37019703168726087 1.870684411427039e-07 6.727999472754487 -0.8583594730381855 STGEAFVQFASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STGEAFVQFASK 12 0 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 59709000.0 19615000.0 18897000.0 21197000.0 False True 26867195.57544374 18062068.055977546 16190705.165918391 1.0 0.6722721768730502 0.6026198424935902 24.67934240348031 -13.999999999999988 0.21766043862466883 2.9576096655916966 0.5645170452682885 0.9994956588808367 0.003890965506173436 12.93705894045964 0.14781598990914765 10.87223561868377 0.03915098514271126 1.0000000000000286e-14 13.999999999999988 -2.393092620323408 STGEAFVQFASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STGEAFVQFASK 12 0 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 71721000.0 16311000.0 32569000.0 22841000.0 False True 21114911.037877936 30756506.51954807 18684172.368451297 1.0 1.4566249634854782 0.8848804683540391 24.331758832947592 -6.693980893893988 1.8520920846199096 1.2851979675041367 0.8867469223954374 0.38918177270562115 0.19296683827228003 0.40817869203391477 2.7175914029134236 0.08325167242126678 0.21572583411041252 2.0231081801985137e-07 6.693980893893988 -0.39845104510869933 STGEAFVQFASK(ub)EIAENALGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STGEAFVQFASKEIAENALGK 21 1 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 17820800.0 11044000.0 4075900.0 2700900.0 True False 14478790.950248126 3467791.60773376 2421436.776862227 1.0 0.23950836914834603 0.1672402609570608 23.787437799581028 -13.999999999999998 0.3328890897588045 9.424082471498346 0.1548704971190823 0.9997208071805678 0.006294136584830681 19.070216389522 0.18465731652202766 112.64284698066686 0.022911609170417825 1.0000000000000041e-14 13.999999999999998 -9.269211974379264 STGEAFVQFASK(ub)EIAENALGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STGEAFVQFASKEIAENALGK 21 1 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 90060800.0 31452600.0 23726800.0 34881400.0 True False 30454154.429282814 33201034.973627463 25744914.92043047 1.0 1.0901972356751242 0.8453662694924725 24.860135712234644 -6.806951073062289 1.4270910624253714 1.0493363375580447 0.8413661633056159 0.8517859709843686 0.038921729939840576 0.21097826228564148 0.8473710963777622 0.02144787805559527 0.049690424144382614 1.5597282094722265e-07 6.806951073062289 -0.2079701742524288 STGEAFVQFASK(ub)EIAENALGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STGEAFVQFASKEIAENALGK 21 1 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 263617000.0 38913000.0 50994000.0 173710000.0 True False 59033865.921362035 41893722.28205945 139376142.36020246 1.0 0.7096557480729 2.3609523141490167 25.81503948614191 -6.86149755254097 1.178052221131861 0.8417863941346934 2.4432694157370056 0.9554406798302576 0.15194743249436773 0.14527224820189527 0.38223522545369043 0.10053204583013127 0.2350963599812636 1.3756325626069406e-07 6.86149755254097 1.6014830216023124 up STGEAFVQFASK(ub)EIAENALGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STGEAFVQFASKEIAENALGK 21 1 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 28225500.0 11044000.0 4312500.0 12869000.0 True False 15127265.252877925 4121959.4904695614 9829607.245374518 1.0 0.272485437490783 0.6497940692554762 23.85064786110392 -10.699426259493071 6.810579660995781 1.0048349806664203 0.46113975337546204 0.731150498808926 0.1540356038951952 0.011344585827189032 0.0005006738724108218 0.14962136216489133 0.04971477738409111 1.9978999706567397e-11 10.699426259493071 -0.5436952272909583 STGEAFVQFASK(ub)EIAENALGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STGEAFVQFASKEIAENALGK 21 1 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 78405000.0 31452600.0 24625000.0 22327400.0 True False 26154230.486433323 24492340.23732022 26995956.10976643 1.0 0.9364580712869699 1.0321831538408184 24.64054098766892 -6.727749294212489 1.731451421216414 0.9616647933609431 1.032102896040786 0.5487690867212868 0.02671662917621752 0.3404862439009612 1.998695178005942 0.012233103706107909 0.030433109468646094 1.8717623434360303e-07 6.727749294212489 0.07043810267984296 STGEAFVQFASK(ub)EIAENALGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STGEAFVQFASKEIAENALGK 21 1 P31942-2;P31942;P31942-3 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 1 210473000.0 38913000.0 39550000.0 132010000.0 True False 50373645.58990516 37349007.73275583 107985534.53698407 1.0 0.741439443093246 2.1436910764033383 25.58616580823436 -6.859104029248056 1.1903101871664874 0.8600440636691764 2.210424511144881 0.9525386490572822 0.132739305371619 0.147724613918516 0.39823249969370195 0.08701107214311214 0.202901924064826 1.3832350044343956e-07 6.859104029248056 1.3503804474757044 up STGEAFVQFASQEIAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STGEAFVQFASQEIAEK 17 0 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;D6RIU0;E7EN40;E5RGH4 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 41226000.0 5543000.0 20581000.0 15102000.0 False True 7266926.6784883505 17510395.024109647 13539389.908613183 1.0 2.4096011696311925 1.8631521284909422 22.792913919279933 -9.878257895805458 5.686460350808455 0.9999995249220959 2.136376649063805 0.8522049030523923 0.22308688688080275 1.3437499274558394e-06 2.64901240555514e-07 0.21600303952223318 0.07200098313580806 1.3235553388400174e-10 9.878257895805458 1.1363771241417093 STGEAFVQFASQEIAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STGEAFVQFASQEIAEK 17 0 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;D6RIU0;E7EN40;E5RGH4 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 70884000.0 22788000.0 14205000.0 33891000.0 False True 22064607.413520552 19877130.57809641 25013930.391793583 1.0 0.900860378141887 1.1336675936715634 24.395230742474645 -6.791006290543407 1.4923195933611622 0.9446619214612357 1.1362117923039197 0.8045396777767923 0.04217318962963728 0.23387026519823628 1.0289009861082008 0.02224266211162901 0.05203738786121901 1.618056600713927e-07 6.791006290543407 0.19154987084268393 STGEAFVQFASQEIAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STGEAFVQFASQEIAEK 17 0 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;D6RIU0;E7EN40;E5RGH4 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 49525000.0 5543000.0 22928000.0 21054000.0 False True 7592396.893942621 21914965.147243153 16081478.820740918 1.0 2.886435661013374 2.118103024035937 22.856123980802824 -10.506487814448404 5.989885683754716 0.9983378654768622 2.502269342524653 0.8359915876236674 0.3136704855536311 0.00696643779582974 0.0005739718228281596 0.3038854088435703 0.1012367138955005 3.115388307152029e-11 10.506487814448404 1.503931477047791 STGEAFVQFASQEIAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STGEAFVQFASQEIAEK 17 0 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;D6RIU0;E7EN40;E5RGH4 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 41477200.0 22788000.0 8624200.0 10065000.0 False True 18949231.679569967 8577739.722830322 12169544.964698052 1.0 0.4526695260198003 0.6422183849184026 24.17563601790892 -10.034330734978367 5.666399442171961 1.0000015268788707 0.5474439554689474 0.8837274446770421 0.07738299760527896 1.4926448640160746e-06 2.5437433015046503e-07 0.07492601754557304 0.024975255083657985 9.23994242340847e-11 10.034330734978367 -0.45255757140992325 STGEAFVQFASQEIAEK(ub)ALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STGEAFVQFASQEIAEKALK 20 1 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;E7EN40;E5RGH4 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 30959000.0 14136000.0 10520000.0 6303000.0 True False 18532432.893218745 8950457.006638829 5650826.022645277 1.0 0.4829617923458887 0.3049154989636027 24.143548951544577 -13.999999999999998 0.1487421534989389 3.4953795357172455 0.10616783389771298 0.9995704926082799 0.006109629206437144 11.953218467867655 0.12139636902916738 8.62425178636127 0.17892634297362411 1.0000000000000041e-14 13.999999999999998 -3.3892117018195327 STGEAFVQFASQEIAEK(ub)ALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STGEAFVQFASQEIAEKALK 20 1 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;E7EN40;E5RGH4 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 109674000.0 36755000.0 34992000.0 37927000.0 True False 35588232.64366986 48964488.080869325 27992780.91438895 1.0 1.3758617510211968 0.7865740677450606 25.08489695279051 -6.7344086647297905 1.7072377081520305 1.2250737144895547 0.7866374789463264 0.5795585520559525 0.15795586089500518 0.32802729777673106 1.8749850808565591 0.07326277082716143 0.18089059057852694 1.8432801033457607e-07 6.7344086647297905 -0.4384362355432283 STGEAFVQFASQEIAEK(ub)ALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STGEAFVQFASQEIAEKALK 20 1 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;E7EN40;E5RGH4 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 37049600.0 14136000.0 9615600.0 13298000.0 True False 19362461.211036094 9190750.997462984 10157286.280906847 1.0 0.4746685298573767 0.5245865270019217 24.20675901306747 -10.418120196145916 9.257097721410847 1.000002054826825 0.4996275291773428 0.9925910080759981 0.02037893699764049 8.642413462893492e-07 5.4345803008584595e-08 0.01973190201496461 0.006577273633772654 3.818385778621597e-11 10.418120196145916 -0.500374525649482 STGEAFVQFASQEIAEK(ub)ALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STGEAFVQFASQEIAEKALK 20 1 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;E7EN40;E5RGH4 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 98711900.0 36755000.0 38118000.0 23838900.0 True False 30563411.022581838 37912650.76816941 28823503.771380052 1.0 1.2404587544288683 0.9430722163204803 24.865302228224785 -6.6915668875902625 1.8608751143756348 1.1505297579291054 0.9440805905274804 0.37778143761363125 0.10166482867219033 0.41329605052822743 2.776028366985688 0.0436861470324339 0.11353645400685215 2.034384847224018e-07 6.6915668875902625 -0.206449167401625 STGEAFVQFASQEIAEKALKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 STGEAFVQFASQEIAEKALKK 21 2 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;E7EN40;E5RGH4 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 57571600.0 8653600.0 13733000.0 35185000.0 True False 13128143.86290181 11282238.853581255 28230669.327866696 1.0 0.8593932981998461 2.150393050432848 23.64615961783133 -6.879911141006795 1.0802608132240614 0.9129500187601853 2.2417420427933537 0.9736151554461637 0.09393529101633322 0.1277103800347856 0.27274326520167874 0.06698802403270429 0.161962272324856 1.318526488589865e-07 6.879911141006795 1.3287920240331683 up STGEAFVQFASQEIAEKALKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STGEAFVQFASQEIAEKALKK 21 2 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;E7EN40;E5RGH4 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 57932600.0 8653600.0 13874000.0 35405000.0 True False 11202255.787957828 13101899.703773823 28961653.285977744 1.0 1.169576909488004 2.5853411878981434 23.41728593992378 -6.9293104487514094 0.7524316705508146 0.9779111698409152 2.8709508052763013 0.9964010008204449 0.04263889060437198 0.09299728363595369 0.07944595831460077 0.03868805018343358 0.12859121100181603 1.176764480746647e-07 6.9293104487514094 1.893039635435386 up STGGAPTFNVTVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STGGAPTFNVTVTK 14 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 2266600000.0 525880000.0 1206300000.0 534420000.0 False True 797798406.9777673 991026340.1350818 428791652.7553934 1.0 1.2422014527320298 0.5374686750500653 29.5714490017925 -6.81390001794374 1.3978598480851938 1.1314033428053143 0.5239811797823883 0.8698281137906236 0.10547989799157095 0.2015211002065062 0.7752862281956439 0.05931788842377902 0.13700242897958445 1.5349703186827838e-07 6.81390001794374 -0.607422163022926 STGGAPTFNVTVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STGGAPTFNVTVTK 14 0 P07737;K7EJ44 P07737 PFN1 Profilin-1 0 1878510000.0 525880000.0 825950000.0 526680000.0 False True 680762026.6445487 779985156.431599 430829644.1931587 1.0 1.1457530324893672 0.6328638016381471 29.34257532388495 -6.83077985024516 1.3244919912082287 1.077838195176571 0.6188478408008224 0.9074138709657718 0.06566054365704435 0.1798500497497178 0.6167857869728272 0.03892127645873575 0.08956392115173825 1.4764547785359743e-07 6.83077985024516 -0.45899035437574853 STGGAPTFNVTVTK(ub)TDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STGGAPTFNVTVTKTDK 17 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 710720000.0 219420000.0 215070000.0 276230000.0 True False 212454632.20443588 300948572.5752336 203877076.27762955 1.0 1.416530999830796 0.9596264113528364 27.66257955855388 -6.66683990172297 1.9491062748076797 1.2665921532997633 0.9615155434341891 0.26498840971229576 0.17706355681020416 0.46835663588764026 3.4273619119163294 0.07322329320658694 0.19640605454690682 2.153575482275447e-07 6.66683990172297 -0.30507660986557417 STGGAPTFNVTVTK(ub)TDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STGGAPTFNVTVTKTDK 17 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 458100000.0 92710000.0 192410000.0 172980000.0 True False 126987392.3935453 183908689.98521706 132125686.63492766 1.0 1.4482436919034258 1.0404630266401433 26.920110029055397 -10.48066602563129 6.634504632363295 0.9999124019098313 1.2443533592717846 0.32375988323757543 0.16647575947795185 0.0002157798097835927 1.6890598547450318e-05 0.16124695587155244 0.05372982033377829 3.306236943784286e-11 10.48066602563129 0.24444095736195326 STGGAPTFNVTVTK(ub)TDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STGGAPTFNVTVTKTDK 17 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 688860000.0 219420000.0 294830000.0 174610000.0 True False 182457451.95415333 293241692.27082694 211120143.69457778 1.0 1.6071784908215792 1.1570924696878186 27.442984833988156 -10.110678110361544 8.216230713597497 0.9999999815320031 1.382135480254699 0.49009005756134016 0.18374684868953986 6.345425836809174e-08 6.7759837544583525e-09 0.17791212917643967 0.0593040404077235 7.750360248441581e-11 10.110678110361544 0.3821354987226959 STGGAPTFNVTVTKTDK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 STGGAPTFNVTVTKTDK 17 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 227895300.0 3893000.0 214945500.0 9056800.0 True False 5103760.699865625 182876469.25099668 8119689.214960145 1.0 35.83170920529474 1.5909227905559766 22.283129256340242 -4.645941954898994 10.495629368407839 9.99999999999819 17.659877276282337 0.0 16.52260855092532 0.0 0.0 5.572458652676974 0.0 2.2597377725434715e-05 4.645941954898994 7.659877276284147 STGGAPTFNVTVTKTDK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 STGGAPTFNVTVTKTDK 17 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 25738700.0 9168300.0 8121500.0 8448900.0 True False 8877257.334973684 11364457.303063007 6235879.628433064 1.0 1.2801766214763781 0.7024556564182951 23.08168258819588 -6.774826660800668 1.5558930764779433 1.159709661399387 0.6985899739039333 0.748696969517205 0.1182515307431115 0.25870099790921514 1.236537996636225 0.0598830968780243 0.1419299955688011 1.6794742099805286e-07 6.774826660800668 -0.4611196874954536 STGGAPTFNVTVTKTDK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 STGGAPTFNVTVTKTDK 17 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 509520000.0 460415000.0 20608000.0 28497000.0 True False 698483215.8451903 16930341.388961073 22864555.459321223 1.0 0.024238723286249247 0.03273458107601666 29.37965020800803 STGGAPTFNVTVTKTDK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STGGAPTFNVTVTKTDK 17 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 23072000.0 3893000.0 10460000.0 8719000.0 True False 5332347.304369229 9997842.613405585 6659751.773441641 1.0 1.8749421301222322 1.2489343610429802 22.346339317863134 -9.946554108714578 5.92710442366391 0.9999996795191503 1.5619382455827935 0.5179274191668269 0.2555666015443669 1.0817402601081929e-06 1.9285436341039036e-07 0.24745144170711217 0.08248376596891598 1.1309564747793717e-10 9.946554108714578 0.5619385660636432 STGGAPTFNVTVTKTDK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STGGAPTFNVTVTKTDK 17 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 33101200.0 9168300.0 15368000.0 8564900.0 True False 7623847.674556835 15285209.533690853 10355780.990376782 1.0 2.0049206366887917 1.3583404905815817 22.862087863630155 -10.221397671660805 4.957233414974462 0.999905847696593 1.6816305636359594 0.5970680449722452 0.26396523929885063 0.00027471524817352625 4.314784677211641e-05 0.2556182436269301 0.08519441464812187 6.006235109730806e-11 10.221397671660805 0.6817247159393665 STGGAPTFNVTVTKTDK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STGGAPTFNVTVTKTDK 17 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 491144000.0 460415000.0 18523000.0 12206000.0 True False 596016293.6364756 17492178.766974382 9984633.24413628 1.0 0.029348490894853415 0.016752282363317644 29.15077653010048 STGK(ub)ANK(ub)ITITNDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STGKANKITITNDK 14 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 2 4894600.0 1557700.0 2036300.0 1300600.0 True False 1508251.6661418704 2849405.209164215 959933.842836351 1.0 1.889210715379506 0.6364546874938157 20.524445745411974 -6.716085989742502 1.7736492481556434 1.543243798255738 0.6388566367220238 0.4938707479972866 0.3743742866578093 0.36297875325152296 2.2294393754812907 0.16774786232774314 0.4230210398342623 1.9227109969427855e-07 6.716085989742502 -0.9043871615337143 STGK(ub)ANK(ub)ITITNDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STGKANKITITNDK 14 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 2 10442900.0 2898600.0 3786500.0 3757800.0 True False 4397388.116045024 3110769.490940467 3015069.182897752 1.0 0.7074129935426915 0.6856500048054619 22.068215440601755 -13.999999999999998 0.36868658141303273 5.04201753790501 0.6833471731100457 0.9997886431471337 0.002083770232099121 22.667323684282735 0.19697195161117156 72.37113138778743 0.006107453829546611 1.0000000000000041e-14 13.999999999999998 -4.358670364794964 STGK(ub)ANK(ub)ITITNDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STGKANKITITNDK 14 2 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6 2 4719260.0 1557700.0 2481500.0 680060.0 True False 1295296.5678105196 2468131.666960815 822257.4017578302 1.0 1.9054568106613416 0.6348024245503233 20.30485102084625 -6.71532301582681 1.7758873784668765 1.5535793380719367 0.637244258148287 0.49054366736624744 0.3812514124290784 0.3644505951645599 2.243588953683249 0.17062494223457725 0.43074826520675646 1.9260918082518105e-07 6.71532301582681 -0.9163350799236497 STGK(ub)ENK(ub)ITITNDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STGKENKITITNDK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 2 10881500.0 3903500.0 4619100.0 2358900.0 True False 5117526.301547778 3929948.285110779 2114823.6561665786 1.0 0.7679390497557737 0.4132511552558035 22.287015181329096 -6.964943332664758 0.3590233099592589 1.030906492395055 0.13814739020269495 0.9999119723453749 0.00226372428093451 0.07798019654676629 0.014927766442720078 0.004768214458421177 0.030312615598277384 1.0840683555081286e-07 6.964943332664758 -0.8927591021923601 down STGK(ub)ENK(ub)ITITNDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STGKENKITITNDK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 2 13168600.0 5611800.0 4523800.0 3033000.0 True False 5433656.4807440145 6330176.931305345 2238566.31195037 1.0 1.1649939508944762 0.4119815670871873 22.37349192965907 -6.849282374908479 1.2385167169006395 1.0879979627617886 0.38228847268709815 0.9392561314748379 0.0796521801103408 0.158251232549542 0.4674803511774442 0.05033300758909867 0.11642373571200128 1.4148735410053576e-07 6.849282374908479 -0.7057094900746905 down STGK(ub)ENK(ub)ITITNDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STGKENKITITNDK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 2 17286800.0 9534100.0 4948200.0 2804500.0 True False 14463926.73607425 4065155.0495369434 2250189.3457439807 1.0 0.28105473179687124 0.15557250716237514 23.785955939432775 -13.999999999999998 0.24556073585211366 5.890211451199011 0.1029437923587029 0.9995345460778211 0.008026408342133577 13.826370658432669 0.15681692483089624 33.26408580729661 0.05937432196627074 1.0000000000000041e-14 13.999999999999998 -5.7872676588403085 STGK(ub)ENK(ub)ITITNDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STGKENKITITNDK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 2 9410700.0 3903500.0 3430600.0 2076600.0 True False 5346729.438121068 3279024.74852287 1586149.8489194731 1.0 0.6132767304708007 0.29665796021219154 22.350225242851987 -7.730746522769352 0.25596841182792596 1.1449390031342326 4.630698340969619e-11 0.9997319058235252 0.004709255256511124 0.1262062405315901 0.03536364443500996 0.0421624162417849 0.081350564425635 1.8588890845287537e-08 7.730746522769352 -1.1449390030879256 down STGK(ub)ENK(ub)ITITNDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STGKENKITITNDK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 2 14669700.0 5611800.0 7383700.0 1674200.0 True False 4666460.344892519 7343922.542550293 2024267.4793738169 1.0 1.5737672667867584 0.4337907813980237 22.153897205093347 -6.769907293434621 1.5752301377265818 1.3291429577866145 0.42746443191962574 0.7300530404762656 0.24180354836369017 0.266580093164285 1.3055040146493329 0.12100708836008954 0.28802211913157955 1.6986062063225934e-07 6.769907293434621 -0.9016785258669888 down STGK(ub)ENK(ub)ITITNDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STGKENKITITNDK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 2 18577700.0 9534100.0 7734800.0 1308800.0 True False 12342080.395207627 7304351.580564358 1070611.82942205 1.0 0.5918249879007922 0.08674484326303397 23.557082261525224 -7.653434177293685 0.5130424338267922 1.0152009293818653 3.07675724134694e-21 0.995469257111421 0.02514285849498834 0.11721029220526677 0.09158985166858077 0.02863070994877992 0.07462238802917925 2.22108829137439e-08 7.653434177293685 -1.0152009293818653 down STGK(ub)ENKITITNDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STGKENKITITNDK 14 2 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6;P54652 A8K7Q2;E9PM13;P11142 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 25355200.0 6835900.0 12257000.0 6262300.0 True False 8849207.305734152 11574887.175231077 5122625.656624166 1.0 1.3080140147390067 0.5788796080418167 23.07711679657561 -6.791937409668132 1.4885900031776556 1.1717149466446541 0.5707060468619062 0.8075450833973606 0.1311086358449084 0.2324715707252085 1.0176109834707328 0.06931857146024059 0.16206525607792577 1.6145912342459325e-07 6.791937409668132 -0.601008899782748 STGK(ub)GIVEFASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STGKGIVEFASK 12 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 6789500.0 1177900.0 1789100.0 3822500.0 True False 1140508.2092498622 2503496.9600332472 2821272.577458061 1.0 2.195071407403418 2.4736977380580845 20.1212454003683 -10.398515979042049 0.31468574369813684 3.1452700358704352e-12 2.5516630672072136 0.9990438438632784 0.01976633571560933 1.9045661756603547 0.14967171150095535 1.6494837394759914 0.0939455916407856 3.994698633016603e-11 10.398515979042049 2.551663067204068 STGLILDSGATHTTAIPVHDGYVLQQGIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STGLILDSGATHTTAIPVHDGYVLQQGIVK 30 0 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 0 28771700.0 8523200.0 15802600.0 4445900.0 False True 11173997.7387862 13444913.678052342 3985880.9160841913 1.0 1.2032321817449039 0.35671037432276825 23.413642097666745 -6.843321900743918 1.2668748323778318 1.1081122435687325 0.32698498037632623 0.9300176421574189 0.09545214639697057 0.16495349294025602 0.5128285421825837 0.059045130624183685 0.13617460773412804 1.4344258372721986e-07 6.843321900743918 -0.7811272631924062 down STGLILDSGATHTTAIPVHDGYVLQQGIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STGLILDSGATHTTAIPVHDGYVLQQGIVK 30 0 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 0 58911900.0 23594300.0 16659600.0 18658000.0 False True 22845311.86136686 23311865.158666275 13770910.071998015 1.0 1.0204222774515235 0.6027893230595665 24.44539480112325 -6.8954068420228465 0.9898745455469022 1.0196188566665843 0.5628245993628875 0.9841384719694884 0.024211368458204978 0.11486476012552421 0.19711095645313723 0.0184916794880744 0.047092747431841664 1.2723106367534466e-07 6.8954068420228465 -0.4567942573036967 STGLILDSGATHTTAIPVHDGYVLQQGIVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STGLILDSGATHTTAIPVHDGYVLQQGIVK 30 0 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 0 181158000.0 16132000.0 142122000.0 22904000.0 False True 24473423.407175303 116759218.6957456 18377014.360820178 1.0 4.770857625971251 0.7508967607462823 24.54471258774176 -6.660591817854595 1.9707696549193514 3.4261031701599545 0.7676622410288596 0.23809117563431303 1.6053262492722882 0.4830710488520021 3.6073693629272925 0.6579571941163361 1.7797191580934304 2.1847823675790853e-07 6.660591817854595 -2.658440929131095 STGLILDSGATHTTAIPVHDGYVLQQGIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STGLILDSGATHTTAIPVHDGYVLQQGIVK 30 0 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 0 51496000.0 8523200.0 17305100.0 25667700.0 False True 11674457.370819366 16540503.461686917 19605517.902875103 1.0 1.4168113288957112 1.679351534734252 23.476852159189637 -9.14673009906911 0.09656746968267013 8.288056029106877e-15 2.5108117006765833 0.9999643436666132 0.0016702657654180894 0.6121739245799642 0.033421382554769036 0.5021469474015507 0.3423161005668291 7.132961844886668e-10 9.14673009906911 2.510811700676575 STGLILDSGATHTTAIPVHDGYVLQQGIVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STGLILDSGATHTTAIPVHDGYVLQQGIVK 30 0 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 0 42724800.0 23594300.0 9369900.0 9760600.0 False True 19619705.854716416 9319422.488920463 11801496.332084633 1.0 0.47500317068617776 0.601512398782862 24.225800076557526 -10.03897736051212 7.3886464718791105 1.0000000366220825 0.5382577847345955 0.946700966167427 0.05164717609837443 3.1175413591686086e-08 4.0341079160267e-09 0.050007167697880724 0.016669054408970478 9.141608948389487e-11 10.03897736051212 -0.46174225188748697 STGLILDSGATHTTAIPVHDGYVLQQGIVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STGLILDSGATHTTAIPVHDGYVLQQGIVK 30 0 O96019;O96019-2 O96019 ACTL6A Actin-like protein 6A 0 54248000.0 16132000.0 17348000.0 20768000.0 False True 20883192.009260405 16382568.549882395 16988437.097675063 1.0 0.784485845967309 0.8134981036491807 24.31583890983421 -10.106346468471411 7.431444812642388 1.0000000459278582 0.7989919748602783 0.9846161659248628 0.011844204601121226 9.012491569019538e-09 1.0807778773190894e-09 0.011468104355617742 0.003822700597434645 7.828048928795932e-11 10.106346468471411 -0.2010080710675799 STGLNFNLHWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STGLNFNLHWR 11 0 Q9NWY4 Q9NWY4 C4orf27 UPF0609 protein C4orf27 0 5432500.0 1185300.0 2502500.0 1744700.0 False True 1553939.7784615282 2129136.754668599 1564175.1803441562 1.0 1.3701539687571047 1.0065867429513655 20.567499163804424 -9.741113957856403 10.601176763846897 1.000000047774471 1.1883703558330707 0.2635833614008043 0.14842569840388486 0.0 0.0 0.1437125645168615 0.047904188172287164 1.815039338204981e-10 9.741113957856403 0.18837030805859967 STGLNFNLHWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STGLNFNLHWR 11 0 Q9NWY4 Q9NWY4 C4orf27 UPF0609 protein C4orf27 0 7654900.0 3211200.0 1752600.0 2691100.0 False True 3109262.213722012 2452422.319688263 1986220.1787305109 1.0 0.788747346191988 0.6388075505387696 21.568140858079246 -7.147043233326613 0.09011123556636934 1.449565738320402 3.5339314757969387e-06 0.9999997266179416 7.725282244749154e-05 0.08333562216242113 0.003370276174712578 0.020603284585938072 0.032862093401384435 7.127820702704265e-08 7.147043233326613 -1.449562204388926 STGLNFNLHWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STGLNFNLHWR 11 0 Q9NWY4 Q9NWY4 C4orf27 UPF0609 protein C4orf27 0 26456700.0 8616300.0 8682900.0 9157500.0 False True 13071557.035906559 7133368.65519266 7347516.111125163 1.0 0.5457168289590786 0.5620995334329417 23.639927664119817 -9.888965521895498 6.867942934017646 1.0000000104448628 0.5539081812111447 0.99898947938224 0.006688211094648662 1.0685109909743296e-09 1.6860494347817836e-10 0.006475832642862109 0.002158610848788288 1.291321785991882e-10 9.888965521895498 -0.44609182923371804 STGLNFNLHWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STGLNFNLHWR 11 0 Q9NWY4 Q9NWY4 C4orf27 UPF0609 protein C4orf27 0 6679100.0 1185300.0 2490000.0 3003800.0 False True 1623537.441528089 2379983.566671122 2294364.3052028893 1.0 1.4659246567366246 1.413188415934166 20.630709225327315 -10.479197778740597 6.034432562170103 0.9996835764056041 1.4395565363353955 0.9893196184372645 0.0215294801530945 9.171592202884493e-05 7.915540779914368e-06 0.02086043019152607 0.0069486098404531555 3.3174334643758786e-11 10.479197778740597 0.43987295992979136 STGLNFNLHWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STGLNFNLHWR 11 0 Q9NWY4 Q9NWY4 C4orf27 UPF0609 protein C4orf27 0 6386800.0 3211200.0 1313800.0 1861800.0 False True 2670255.080280634 1306722.298631117 2251093.772009422 1.0 0.4893623490433675 0.8430257426091444 21.348546133513523 -10.150302667981684 5.7067867655152575 1.0000047255524729 0.6661940458262385 0.5429217442149434 0.14438247582294977 8.680867018642824e-06 1.2926079187625792e-06 0.1397997095469201 0.046599243695529334 7.074525755530418e-11 10.150302667981684 -0.33381067972623435 STGLNFNLHWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STGLNFNLHWR 11 0 Q9NWY4 Q9NWY4 C4orf27 UPF0609 protein C4orf27 0 25346700.0 8616300.0 8438600.0 8291800.0 False True 11153970.20266492 7968984.491874426 6782777.481052695 1.0 0.7144527327113055 0.6081043214040635 23.411053986212266 -13.999999999999998 0.13715131431948385 2.360972685228921 0.47186371137543726 0.9996145307596246 0.003248771951934819 11.932189285302853 0.11581414398979749 4.353625308732687 0.1215793690914101 1.0000000000000041e-14 13.999999999999998 -1.8891089738534839 STHDHWK(ub)ALVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STHDHWKALVTK 12 1 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 1 7742810.0 2251100.0 4647400.0 844310.0 True False 1871889.3906389312 4622363.533763323 1020851.317351636 1.0 2.4693571943295076 0.5453587815908232 20.836063758363423 -6.702560978765505 1.8214676097607607 1.9100790901940548 0.5507406633206934 0.4299167866847686 0.6199433646740155 0.39019062402958216 2.5184708170177146 0.2713308403433707 0.6956635450204242 1.9835311320643423e-07 6.702560978765505 -1.3593384268733613 STIAIEK(ub)FK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STIAIEKFK 9 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 4567510.0 956910.0 1517800.0 2092800.0 True False 926533.4158360518 2123865.455222439 1544632.8973457739 1.0 2.2922707577750794 1.6671097565887396 19.821483483060224 -10.03710458203355 5.591260893656719 0.9999959515454051 1.9796902571823716 0.7660493773558139 0.2552209100006297 1.2880218783199157e-05 2.2184640417157135e-06 0.2471176065076772 0.08237219450279161 9.181114803249286e-11 10.03710458203355 0.9796943056369665 STIAIEK(ub)FK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STIAIEKFK 9 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 4788710.0 956910.0 2065600.0 1766200.0 True False 795713.0633007414 2054472.2028105003 2135504.2540138774 1.0 2.58192594487293 2.6837617132430553 19.6018887584945 -10.577426492969384 0.5307122554185925 1.348734914844973e-18 2.677001395859193 0.9997181301660868 0.012941815318948922 2.0289227998857773 0.2547216753811469 2.738161974674873 0.019586258036245984 2.6459004918708802e-11 10.577426492969384 2.677001395859193 STIGAYFLKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STIGAYFLKPK 11 1 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 44249700.0 12783800.0 8948400.0 22517500.0 False True 16759685.598495295 7613333.600590004 20187605.103112 1.0 0.4542647029890309 1.204533640232754 23.998491749421465 -6.711654529693068 1.789435995777099 0.6650611428468011 1.2028488148707064 0.4729106136636039 0.22991113492289267 0.37175337019376536 2.3214878470949873 0.1022091409654465 0.25912710949316226 1.9424304175968203e-07 6.711654529693068 0.5377876720239053 STIGAYFLKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STIGAYFLKPK 11 1 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 36443610.0 7651400.0 3296110.0 25496100.0 False True 7408510.495164607 4612263.911986581 18817906.54339527 1.0 0.622562918011241 2.5400391287394894 22.820752082537243 -6.855602780884288 1.2078204787654792 0.7971717139147988 2.6253572719317924 0.9480572719801543 0.18902437758627916 0.15140386899687874 0.4222403696917145 0.12226411736374225 0.2841206987946456 1.3944316099867253e-07 6.855602780884288 1.8281855580169935 up STIGAYFLKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STIGAYFLKPK 11 1 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 30933900.0 12783800.0 8204500.0 9945600.0 False True 17510316.329205073 7841998.061346663 7596654.11606161 1.0 0.44785016523471743 0.43383877099874646 24.061701810944356 STIGAYFLKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STIGAYFLKPK 11 1 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 19781000.0 7651400.0 6757100.0 5372500.0 False True 6362478.114492784 6720698.161120665 6495864.91036665 1.0 1.0563019691669995 1.0209645979873834 22.60115735797152 -10.12480770730829 4.804489169427303 0.9999975894894582 1.0386332835774748 0.6144432321822526 0.014426421374540917 3.725135108979714e-07 6.785206890881426e-08 0.013969193978826355 0.0046561074772753 7.502263137231101e-11 10.12480770730829 0.03863569408801659 STIGAYFLKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STIGAYFLKPK 11 1 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 22626800.0 7130300.0 9022700.0 6473800.0 False True 9230313.909225738 8520578.813409263 5295634.826797427 1.0 0.9231082384850323 0.5737220726051816 23.13794828193871 -6.9419604150028835 0.6410747642178479 1.0038277971826888 0.4738120982119001 0.9984094594512535 0.007398074815552548 0.08688380332900059 0.050623293607337874 0.00731326170420198 0.02982093746524715 1.1429825104110077e-07 6.9419604150028835 -0.5300156989707887 STIGAYFLKPKELK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 STIGAYFLKPKELK 14 2 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 1 7193100.0 3351400.0 2758800.0 1082900.0 True False 3245011.6414636113 3860403.2269519386 799256.0036963586 1.0 1.189642335215403 0.24630296960533146 21.629792223219372 -6.854407162656836 1.2136049734316716 1.1017229988759887 0.2052549021594521 0.9464772140861866 0.09425636631509798 0.15267828009792475 0.4305124889827624 0.060696936943018934 0.14091356292883936 1.3982757870348686e-07 6.854407162656836 -0.8964680967165366 down STIGGQIMYLTGMVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STIGGQIMYLTGMVDK 16 0 P15170-2;P15170-3;P15170;H3BR35;H3BSV8 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 0 11704500.0 3954700.0 2805900.0 4943900.0 False True 3829160.2131933346 3926310.502575197 3648944.276179178 1.0 1.025371173827392 0.95293591101432 21.868596593561342 -6.812072142622022 1.4058359637629145 1.0137934221423708 0.9516080481931418 0.8651665716629175 0.01101970220319599 0.2039851227811159 0.7941790092501962 0.006162853785546542 0.014242828736972628 1.541444375379216e-07 6.812072142622022 -0.06218537394922896 STIGGQIMYLTGMVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STIGGQIMYLTGMVDK 16 0 P15170-2;P15170-3;P15170;H3BR35;H3BSV8 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 0 7264200.0 1096800.0 1362300.0 4805100.0 False True 1502316.599905517 1302109.0814763312 3670234.344140889 1.0 0.8667341368378828 2.4430498500593787 20.518757449407715 -6.886354178741287 1.0436852477010967 0.9077534227542372 2.569337036703542 0.978461206349608 0.10475035360763313 0.12215207833090327 0.23951446036571752 0.07681443148529966 0.18915510913443118 1.2991096872842914e-07 6.886354178741287 1.6615836139493048 up STIGGQIMYLTGMVDKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STIGGQIMYLTGMVDKR 17 1 P15170-2;P15170-3;P15170;H3BR35;H3BSV8 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 0 7674700.0 1882300.0 2691500.0 3100900.0 False True 2467713.5282191294 2289938.691384831 2780048.6139331637 1.0 0.9279596943480741 1.126568615903904 21.234743494036074 -6.808546236982726 1.4204478343656453 0.960671015617098 1.129935290407458 0.8560565876492972 0.031146386385803956 0.20878087359045383 0.8304907511970175 0.01724216018544497 0.03991504137919186 1.5540098349486136e-07 6.808546236982726 0.16926427479036 STIGGQIMYLTGMVDKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STIGGQIMYLTGMVDKR 17 1 P15170-2;P15170-3;P15170;H3BR35;H3BSV8 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 0 18264000.0 6226900.0 4431600.0 7605500.0 False True 6029230.467932739 6201160.990488703 5613391.389890713 1.0 1.028516163624927 0.9310294936885027 22.523542446914938 -6.8284043548087 1.3349969694378714 1.0152551430780736 0.9284902729397765 0.9026433972395158 0.012769447591641017 0.1827945067710335 0.6376958262183547 0.0075112962422873705 0.017287327942418135 1.484552788895338e-07 6.8284043548087 -0.08676487013829715 STIGGQIMYLTGMVDKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STIGGQIMYLTGMVDKR 17 1 P15170-2;P15170-3;P15170;H3BR35;H3BSV8 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 0 33640100.0 5942100.0 14574000.0 13124000.0 False True 9014600.12569901 11973155.832818262 10530035.64754646 1.0 1.3281960004731592 1.1681090121265851 23.10383206658734 -10.195522976983504 4.914771963718607 0.9999724022048027 1.2481525063003316 0.762119401793562 0.06535523931963853 1.9766647442969002e-05 3.2354665416602277e-06 0.06328697004961323 0.021093312789129168 6.374953525205101e-11 10.195522976983504 0.24818010409552893 STIGGQIMYLTGMVDKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STIGGQIMYLTGMVDKR 17 1 P15170-2;P15170-3;P15170;H3BR35;H3BSV8 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 0 18890300.0 1882300.0 5069000.0 11939000.0 False True 2578237.177244851 4845034.819058595 9119254.091423295 1.0 1.879204466454899 3.5370113238256415 21.297953555558966 -6.961180524366017 0.41846416413232396 0.9254991024939662 4.553096075902842 0.999811506965172 0.014441323104304534 0.07928208964381595 0.019592876252828993 0.021425098014786575 0.1380591896313379 1.0935017329560827e-07 6.961180524366017 3.627596973408876 STIGGQIMYLTGMVDKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STIGGQIMYLTGMVDKR 17 1 P15170-2;P15170-3;P15170;H3BR35;H3BSV8 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 0 13900500.0 6226900.0 3868300.0 3805300.0 False True 5177943.248442792 3847460.7001025667 4600970.636280727 1.0 0.7430480628113579 0.8885710822853101 22.303947722349214 -10.153275799182236 4.9829932478142585 1.0000111184882174 0.8158095727050128 0.6811265503036741 0.0594095239247815 7.338719356606371e-06 1.2470161766152135e-06 0.05752649533646375 0.019174341397032127 7.026259747847529e-11 10.153275799182236 -0.1842015457832047 STIGGQIMYLTGMVDKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STIGGQIMYLTGMVDKR 17 1 P15170-2;P15170-3;P15170;H3BR35;H3BSV8 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 0 38180100.0 5942100.0 17798000.0 14440000.0 False True 7692165.586302152 16807525.654300597 11812068.166911993 1.0 2.1850187006154225 1.5355972299850604 22.87495838867979 -10.077545280897128 4.835967425726818 0.9999754720662084 1.8603079653084933 0.7005879257973393 0.26512520522413213 8.508278445703841e-05 1.6229162067487448e-05 0.25671522936953367 0.08556879203399223 8.364783773646881e-11 10.077545280897128 0.8603324932422849 STIGVEFATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STIGVEFATR 10 0 H3BSC1;P62491;H3BMH2;P62491-2;Q15907-2;Q15907 H3BSC1 RAB11A;RAB11B Ras-related protein Rab-11A;Ras-related protein Rab-11B 0 65580830.0 21962830.0 19619000.0 23999000.0 False True 28793482.81834825 16691921.674263049 21515813.69466349 1.0 0.5797117972691498 0.7472459594555485 24.77923896998889 -10.117062823399687 5.180563649287939 1.0000089722235548 0.6634788783619248 0.843252383795931 0.0683955353083732 7.087915323739974e-06 1.2081083316942606e-06 0.06622545695656831 0.022074564100142954 7.637252979691881e-11 10.117062823399687 -0.33653009386163 STIGVEFATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STIGVEFATR 10 0 H3BSC1;P62491;H3BMH2;P62491-2;Q15907-2;Q15907 H3BSC1 RAB11A;RAB11B Ras-related protein Rab-11A;Ras-related protein Rab-11B 0 27889700.0 9679800.0 6654900.0 11555000.0 False True 9372520.047454642 9312236.274845043 8528398.85743043 1.0 0.9935680294835997 0.9099365820771484 23.160005575709235 -6.92226867513137 0.8077184194638979 1.001698777570314 0.8957202821001767 0.9947882881884647 0.0029616351453900036 0.09685539387654919 0.09883045895366563 0.0025828950604157106 0.007913123677410703 1.196000399909869e-07 6.92226867513137 -0.10597849547013716 STIGVEFATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STIGVEFATR 10 0 H3BSC1;P62491;H3BMH2;P62491-2;Q15907-2;Q15907 H3BSC1 RAB11A;RAB11B Ras-related protein Rab-11A;Ras-related protein Rab-11B 0 55010830.0 21962830.0 20284000.0 12764000.0 False True 30083081.774163786 19387785.809781916 9749406.082831632 1.0 0.6444747235448698 0.32408269059736766 24.84244903151178 -7.483101446522338 0.25798547435386543 1.123288338208012 1.8678106086420585e-15 0.9998570563979499 0.0033006168521845696 0.12483406936998291 0.024769284931155208 0.024949388733528716 0.0636601188952457 3.287748236411635e-08 7.483101446522338 -1.1232883382080103 down STIGVEFATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STIGVEFATR 10 0 H3BSC1;P62491;H3BMH2;P62491-2;Q15907-2;Q15907 H3BSC1 RAB11A;RAB11B Ras-related protein Rab-11A;Ras-related protein Rab-11B 0 20386200.0 9679800.0 5718300.0 4988100.0 False True 8049182.5878489325 5687494.3829063205 6031088.647631433 1.0 0.7065927901166235 0.7492796419770599 22.94041085114351 -10.300356318193014 6.841950442549045 1.0000044436815556 0.7279362160469999 0.9818714639266558 0.017426834297307337 1.1812743847414658e-06 1.2079757546699974e-07 0.016873735244433394 0.0056244865842156305 5.0077620171736117e-11 10.300356318193014 -0.27206822763455574 STIK(ub)TDLDDDITALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STIKTDLDDDITALK 15 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 1 7937400.0 2999100.0 4938300.0 0.0 True False 3931849.143325717 4201524.889342631 0.0 1.0 1.068587510910658 0.0 21.906776538929673 -6.977610495587552 1.1571165524292109 1.0462138333177005 7.254785273373124e-22 0.9792424086974469 0.07036247659247112 0.09776574584433274 0.2580811857132081 0.05098174068447585 0.09486373984862148 1.0529057669797324e-07 6.977610495587552 -1.0462138333177005 down STIK(ub)TDLDDDITALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STIKTDLDDDITALK 15 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 1 39270400.0 10017000.0 8261400.0 20992000.0 True False 9699015.818028577 11560220.102631848 15493565.453498904 1.0 1.1918962005550766 1.5974368682541367 23.209406930388262 -6.958952881791421 0.4499527175229994 0.9869158354057519 1.8184927130736148 0.9997293563445905 0.004097125188559712 0.08007737829649234 0.022529989640036784 0.005420079076086298 0.033545113110959444 1.0991250810938948e-07 6.958952881791421 0.8315768776678629 STIK(ub)TDLDDDITALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STIKTDLDDDITALK 15 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 1 18190900.0 2999100.0 6664900.0 8526900.0 True False 4107948.317630048 6370422.680123025 6513021.837017944 1.0 1.5507553132504452 1.5854683003352457 21.969986600452565 -11.512447534141629 0.453845860557205 6.984130757246528e-18 1.5854828414142235 0.99978607207528 0.0039225457439167055 4.1184319472845665 0.2245780456267044 4.052309834323106 0.007761983295707219 3.0729285744446063e-12 11.512447534141629 1.5854828414142235 STIK(ub)TDLDDDITALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STIKTDLDDDITALK 15 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 1 24996800.0 10017000.0 7324700.0 7655100.0 True False 8329579.328341767 7285240.387260892 9255746.016816698 1.0 0.8746228470953551 1.1111900915960553 22.98981220582254 -6.762736223644623 1.602377401928959 0.927421545030503 1.1121669893849164 0.7019633134976009 0.052756261499637615 0.27834271410206035 1.4091750996143295 0.02597080187582574 0.06223930830244365 1.7268864282337692e-07 6.762736223644623 0.18474544435441342 STIVK(ub)QMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STIVKQMR 8 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;P38405;P38405-2;Q5JWD1;Q5JWE9;A2A2R6;H0Y7E8;P63092-2;Q5JWF2-2;P63092-3;H0Y7F4 P63092;P63092-2;P63092-3 GNAS;GNAL Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha 1 17726000.0 962100.0 1906900.0 14857000.0 True False 1261322.4169896545 1622397.9530379833 13319740.158407237 1.0 1.28626743740121 10.560139088145998 20.2665056712684 -6.91348316977501 0.8716734659635207 0.7435187395341724 11.852430346140926 0.9921710971074673 0.39292300897422344 0.10215962852712598 0.1266047434020879 0.3273375182727411 0.9269758975656733 1.220441115613178e-07 6.91348316977501 11.108911606606753 up STIVK(ub)QMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STIVKQMR 8 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;P38405;P38405-2;Q5JWD1;Q5JWE9;A2A2R6;H0Y7E8;P63092-2;Q5JWF2-2;P63092-3;H0Y7F4 P63092;P63092-2;P63092-3 GNAS;GNAL Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha 1 22755800.0 1264900.0 4509900.0 16981000.0 True False 1224746.4418712545 6310726.5888178125 12533166.680919627 1.0 5.15268007570272 10.233274621129388 20.224051669638833 -6.968422488978601 0.2934331655196887 0.04718011053919793 15.49649927450518 0.9999673281215191 0.021582262507907478 0.07681802207002528 0.010852942300744241 0.08715857567519791 0.45893160991134474 1.0754185193629209e-07 6.968422488978601 15.449319163965981 STIVK(ub)QMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STIVKQMR 8 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;P38405;P38405-2;Q5JWD1;Q5JWE9;A2A2R6;H0Y7E8;P63092-2;Q5JWF2-2;P63092-3;H0Y7F4 P63092;P63092-2;P63092-3 GNAS;GNAL Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha 1 18572630.0 900630.0 7964000.0 9708000.0 True False 1366321.554872569 6542761.97698399 7789209.544832451 1.0 4.788596032647824 5.7008612043443305 20.38186562178612 -9.457638188836315 0.43380564816455797 1.1989461855170228e-18 5.774434957018717 0.9982061902039875 0.08620390307111826 0.7983985825322015 0.17973893418706754 1.5063769382692989 0.21132922869021076 3.4862763611531003e-10 9.457638188836315 5.774434957018717 STIVK(ub)QMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STIVKQMR 8 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;P38405;P38405-2;Q5JWD1;Q5JWE9;A2A2R6;H0Y7E8;P63092-2;Q5JWF2-2;P63092-3;H0Y7F4 P63092;P63092-2;P63092-3 GNAS;GNAL Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha 1 19644600.0 962100.0 1808500.0 16874000.0 True False 1317814.3697748887 1728594.4900902489 12888708.730938664 1.0 1.3117131894574274 9.780367422416509 20.329715732791293 -6.914689109709636 0.8631963549966024 0.7750581306950506 10.992083467659581 0.9925739868317315 0.35052476919195824 0.10139812063106417 0.12255323473822265 0.2938069361173545 0.8399709284607355 1.2170569207219938e-07 6.914689109709636 10.21702533696453 up STIVK(ub)QMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STIVKQMR 8 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;P38405;P38405-2;Q5JWD1;Q5JWE9;A2A2R6;H0Y7E8;P63092-2;Q5JWF2-2;P63092-3;H0Y7F4 P63092;P63092-2;P63092-3 GNAS;GNAL Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha 1 18946800.0 1264900.0 5327900.0 12354000.0 True False 1051820.39457118 5299197.545194649 14937164.281557838 1.0 5.038120170083882 14.201249907925218 20.00445694507311 -6.957503309725178 0.46930744324843265 0.7563403439576476 18.858229554877777 0.9996660684841919 0.10092810763989288 0.08060547757500983 0.024521185828719195 0.1265308614147487 0.756320462824948 1.1027998294639979e-07 6.957503309725178 18.10188921092013 STIVK(ub)QMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STIVKQMR 8 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;P38405;P38405-2;Q5JWD1;Q5JWE9;A2A2R6;H0Y7E8;P63092-2;Q5JWF2-2;P63092-3;H0Y7F4 P63092;P63092-2;P63092-3 GNAS;GNAL Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha 1 11770730.0 900630.0 6890900.0 3979200.0 True False 1165883.2890714228 6507415.357412067 3255026.430039899 1.0 5.581532404152521 2.7918973198701487 20.15299194387857 -9.504229028563968 9.110409840770785 1.000087577589733 4.186714862011342 0.6350264132445783 1.1388637552987584 0.0 0.0 1.1027001053907217 0.36756669632021616 3.1316337973996713e-10 9.504229028563968 3.1866272844216086 STK(ub)FQQIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STKFQQIVR 9 1 Q96G46-3;Q96G46;Q96G46-2;K7ER20;K7EQU9 Q96G46-3 DUS3L tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like 1 4391300.0 1245800.0 1246900.0 1898600.0 True False 1633255.8643443615 1060867.3803781322 1702151.084657199 1.0 0.6495414487943667 1.0421827478577548 20.639319389192018 -6.671357320313613 1.932754834457814 0.7765598551750513 1.040597603476467 0.28495573096864735 0.14882177868051358 0.4580296890597535 3.2999713625121 0.0619633278738385 0.16524637376645115 2.131290649969973e-07 6.671357320313613 0.2640377483014157 STK(ub)FQQIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STKFQQIVR 9 1 Q96G46-3;Q96G46;Q96G46-2;K7ER20;K7EQU9 Q96G46-3 DUS3L tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like 1 7702800.0 1325100.0 1502100.0 4875600.0 True False 1283035.425823069 2101896.363348019 3598534.0951352525 1.0 1.6382216118464925 2.80470361356296 20.29112957447794 -6.961767661789257 0.4097612536265896 0.9423884325530978 3.5438092699314656 0.999830243365837 0.009735504170807456 0.07907561978169225 0.018842001282715636 0.015019594977712006 0.09740003461183845 1.0920243897774898e-07 6.961767661789257 2.6014208373783676 STK(ub)FQQIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STKFQQIVR 9 1 Q96G46-3;Q96G46;Q96G46-2;K7ER20;K7EQU9 Q96G46-3 DUS3L tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like 1 6737700.0 1325100.0 2880800.0 2531800.0 True False 1101879.3618833672 2865280.558605974 3061187.6742794355 1.0 2.6003577684843333 2.7781513840563785 20.071534849912215 -10.444709994291706 0.4503488335862353 1.3765608881862465e-19 2.7815489142050303 0.9994206615685278 0.019246494155264752 1.8560397014639618 0.21211275907978963 2.2185136961600236 0.03994323863034989 3.591616894092806e-11 10.444709994291706 2.7815489142050303 STK(ub)FQQIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STKFQQIVR 9 1 Q96G46-3;Q96G46;Q96G46-2;K7ER20;K7EQU9 Q96G46-3 DUS3L tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like 1 7194200.0 2148000.0 1748900.0 3297300.0 True False 2780628.3434100794 1651572.177593343 2697225.2331550447 1.0 0.5939564636559463 0.9700056606080798 21.406979497413747 -10.473251928928011 8.825948377243693 1.0000048915097877 0.7819810637874709 0.3094709054812105 0.153521441786017 1.477695024896999e-05 8.819310673128556e-07 0.1486498290023414 0.049548832276916276 3.363164197289479e-11 10.473251928928011 -0.21802382772231677 STK(ub)GDGEDNRPGMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 STKGDGEDNRPGMR 14 2 Q9UL63;C9J7E8;Q9UL63-2 Q9UL63 MKLN1 Muskelin 1 42381400.0 12788200.0 18913700.0 10679500.0 True False 16765454.041104954 16091849.685025152 9574487.784997657 1.0 0.959821884070167 0.571084311914444 23.998988218860113 -6.926740736432518 0.7730818801943461 1.0066806401118982 0.4975229861879894 0.9958578519552453 0.012448383743099934 0.0943660657462359 0.08623401896622636 0.011128414893077837 0.0358251438354288 1.1837480144931195e-07 6.926740736432518 -0.5091576539239088 STK(ub)GDGEDNRPGMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 STKGDGEDNRPGMR 14 2 Q9UL63;C9J7E8;Q9UL63-2 Q9UL63 MKLN1 Muskelin 1 58506150.0 26006600.0 23907300.0 8592250.0 True False 25181034.718293138 33453609.56492253 6341681.963025241 1.0 1.32852402370184 0.25184358124959144 24.58583423052024 -6.824836616367768 1.3509260580063511 1.176258593065068 0.22583047302438677 0.8951229223293742 0.145907371640488 0.18727359772899882 0.6702223961958619 0.084845251749555 0.19533825344825834 1.4967986528989153e-07 6.824836616367768 -0.9504281200406812 down STK(ub)GDGEDNRPGMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STKGDGEDNRPGMR 14 2 Q9UL63;C9J7E8;Q9UL63-2 Q9UL63 MKLN1 Muskelin 1 31318500.0 11257600.0 8574500.0 11486400.0 True False 17078602.240801908 7044313.482125719 9216108.00533203 1.0 0.4124642861753867 0.539628938913639 24.02568656992048 -9.857476978555955 6.657666220378548 1.000000012964501 0.4760466125449359 0.9576908667217356 0.051914752087914254 1.0030087512500005e-08 1.6875855727985382e-09 0.05026624406275261 0.01675541418823462 1.3884269068696424e-10 9.857476978555955 -0.5239534004195652 STK(ub)GDGEDNRPGMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 STKGDGEDNRPGMR 14 2 Q9UL63;C9J7E8;Q9UL63-2 Q9UL63 MKLN1 Muskelin 1 42804990.0 12788200.0 19928100.0 10088690.0 True False 17516343.128110602 19047610.64858583 7705949.20509266 1.0 1.087419360837812 0.439929107847059 24.062198280383004 -6.872831404268817 1.1189456222355258 1.050403282744693 0.39990048550903246 0.9674313366949195 0.05176787678566686 0.13417224028201524 0.31224143873490356 0.035838476062887765 0.08529587553263374 1.3401968589376386e-07 6.872831404268817 -0.6505027972356605 down STK(ub)GDGEDNRPGMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 STKGDGEDNRPGMR 14 2 Q9UL63;C9J7E8;Q9UL63-2 Q9UL63 MKLN1 Muskelin 1 55180910.0 26006600.0 24965700.0 4208610.0 True False 21625640.1877262 24831204.818796538 5088610.89258597 1.0 1.1482298143890177 0.23530452039399283 24.366239505954518 -6.8652741871269924 1.158879058272879 1.0818502187206782 0.18644621808176348 0.9597304999386886 0.08027361392268863 0.14146238145125437 0.3580727960021162 0.053900303710423016 0.12665742919958123 1.3637218936718142e-07 6.8652741871269924 -0.8954040006389148 down STK(ub)GDGEDNRPGMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STKGDGEDNRPGMR 14 2 Q9UL63;C9J7E8;Q9UL63-2 Q9UL63 MKLN1 Muskelin 1 22622100.0 11257600.0 5842700.0 5521800.0 True False 14573185.120471716 5517548.60885393 4516889.05845254 1.0 0.3786096562448205 0.30994521932665425 23.79681289201293 -13.999999999999998 0.31101538581146215 7.0423740684569385 0.2949037900414361 0.9996742260350266 0.005602093446705254 17.342314422767842 0.17748285000453912 67.85214615570077 0.02369604493118631 1.0000000000000041e-14 13.999999999999998 -6.747470278415502 STK(ub)TGTAYTFFTPNNIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STKTGTAYTFFTPNNIK 17 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 32147100.0 9450100.0 10410000.0 12287000.0 True False 9150111.748223206 14566767.287432848 9068666.097901145 1.0 1.5919769821676182 0.9910989447382568 23.125357932133202 -10.286368857154438 3.994033992741493 0.9995892450195636 1.2915379634790496 0.23889241275616435 0.24530743164623414 173906007.6788958 445.10040463505504 658217.0394295382 0.08397525863464064 5.171674021714154e-11 10.286368857154438 0.291948718459486 STK(ub)TGTAYTFFTPNNIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STKTGTAYTFFTPNNIK 17 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 14576300.0 3248400.0 6128600.0 5199300.0 True False 4449421.264709226 5857818.187429971 3971332.4229447255 1.0 1.3165348567669926 0.892550331083172 22.08518626656461 -6.706852297160004 1.806358168145536 1.1952234648632833 0.8936344114601843 0.4501251636530039 0.1334540944946827 0.3814626794960031 2.4242740954977284 0.05883641228991075 0.1500492170240665 1.9640281260022784e-07 6.706852297160004 -0.30158905340309905 STK(ub)TGTAYTFFTPNNIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STKTGTAYTFFTPNNIK 17 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 29705400.0 9450100.0 13795000.0 6460300.0 True False 7858176.860413552 13720683.596906906 7811118.860947719 1.0 1.7460390419597693 0.9940115881454777 22.905763207567478 -10.239708061392355 4.002160816646834 0.9996815254008583 1.3700253150861512 0.24402811289260407 0.3070139227191837 108332168.37070608 196.45765592589385 334710.1515024859 0.10509903179002401 5.758268858648759e-11 10.239708061392355 0.3703437896852929 STK(ub)TGTAYTFFTPNNIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STKTGTAYTFFTPNNIK 17 1 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 1 60997000.0 12514000.0 21446000.0 27037000.0 True False 16199619.687818306 20252511.247450892 22116543.423047047 1.0 1.2501843646786508 1.3652507805277747 23.949456608127672 -13.117026553781594 0.11239396222650358 1.166456847161655e-17 1.5786754311379747 0.9997555192038924 0.0023840911532846975 8.850245021843284 0.09370677772746232 2.1419107495589613 0.17837364979556852 7.637890822969657e-14 13.117026553781594 1.5786754311379747 STKKEVFNILQAAYVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STKKEVFNILQAAYVSK 17 2 P08581-3;P08581;P08581-2 P08581-3 MET Hepatocyte growth factor receptor 0 10357900.0 4601100.0 2378500.0 3378300.0 False True 3826018.513290738 2365686.5484047127 4084686.9105056506 1.0 0.6183154995687666 1.0676077223140337 21.867412423919887 -6.681588728524972 1.8958638494198476 0.7588581644082515 1.0659363478576367 0.33161622082954445 0.16170945618089796 0.4349814772334625 3.0240359025269137 0.06840220507472089 0.18006489377467047 2.0816670668260035e-07 6.681588728524972 0.3070781834493852 STLDIVLANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STLDIVLANK 10 0 P23921 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 0 8824300.0 2662900.0 2845700.0 3315700.0 False True 3491087.6875602817 2421132.6524517224 2972623.17044026 1.0 0.6935181436659104 0.8514891164242435 21.735245163630935 -10.143697208353482 4.630614633153258 1.0000220291406825 0.7725036300437285 0.7344127968266775 0.06449137960020948 90171590.26681378 0.729035485452429 23696.56531250515 0.022077114602813436 7.18294914484024e-11 10.143697208353482 -0.22751839909695404 STLDIVLANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STLDIVLANK 10 0 P23921 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 0 9537300.0 2261400.0 1439100.0 5836800.0 False True 2189613.0948277772 2013740.1348073597 4307966.979753354 1.0 0.9196785220019654 1.9674557984373922 21.062244537102142 -6.88839606219772 1.0317859946076269 0.9415182298522067 2.0548051540153516 0.9798530710918755 0.06758119598723522 0.12045572940879821 0.22950743684318065 0.05000738115835708 0.1239750676086511 1.293016115681655e-07 6.88839606219772 1.113286924163145 STLDIVLANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STLDIVLANK 10 0 P23921 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 0 7696800.0 2662900.0 2199100.0 2834800.0 False True 3647446.092166664 2101936.49054878 2165278.624538636 1.0 0.5762762320361486 0.5936423924643701 21.798455225153827 -10.180471811262187 8.131038073496525 1.0000000900483499 0.5849593122602053 0.9986886520677403 0.007089705306742605 1.1569914780478431e-08 1.163670058368244e-09 0.006864579128821198 0.0022881925485443693 6.5997606991869e-11 10.180471811262187 -0.41504077778814463 STLDIVLANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STLDIVLANK 10 0 P23921 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 0 5824400.0 2261400.0 1715500.0 1847500.0 False True 1880454.2970062986 1706258.2609999094 2233803.7081251494 1.0 0.9073649190604042 1.1879064073407084 20.84264981253642 -6.817712728689671 1.381644881379436 0.9499514416724167 1.193740432339905 0.8790644552678688 0.040587250146361144 0.1964690856861469 0.7375442662261983 0.02308752767476869 0.053250714440057315 1.5215536539152015e-07 6.817712728689671 0.24378899066748827 STLEPVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STLEPVEK 8 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066;P48741 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6;HSPA7 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 13454440.0 729540.0 6466700.0 6258200.0 False True 956434.0048754108 5501893.566999172 5610661.496893334 1.0 5.752507270709046 5.866229628278642 19.86730589870739 -10.145057708774443 0.8010263235968827 2.0804405405403543e-12 5.842053531649748 0.9999265916389388 0.01942878219044683 1.447618805182644 0.4226927009744163 3.503839873455545 0.01637504963921768 7.160482558543518e-11 10.145057708774443 5.842053531647668 STLEPVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STLEPVEK 8 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066;P48741 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6;HSPA7 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 18425300.0 3710700.0 2399600.0 12315000.0 False True 3592905.8596344907 3357772.793748685 9089332.057919156 1.0 0.9345562964709223 2.529799669965141 21.776719704047007 -6.897334300811769 0.9779803885798046 0.9287379213781198 2.6884625093042533 0.9851923479449024 0.08969089456814891 0.11339365577580149 0.1886987040717719 0.06911432353410793 0.1775326007058931 1.2666764586058226e-07 6.897334300811769 1.7597245879261334 up STLEPVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STLEPVEK 8 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066;P48741 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6;HSPA7 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 121881600.0 2680400.0 114470000.0 4731200.0 False True 4066362.763488261 94041934.14180778 3796076.2462413767 1.0 23.12679404459613 0.9335311350788036 21.955307494231434 -12.690801494730307 1.4839467102972957e-12 8.209312077921059 13.64498069387479 0.0 10.758748132645 0.0 0.7335137468982296 509776667.1736243 509776664.7073276 2.037973372092925e-13 12.690801494730307 5.435668615953732 STLEPVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STLEPVEK 8 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066;P48741 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6;HSPA7 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 16400240.0 729540.0 7597200.0 8073500.0 False True 999270.6530771984 7261530.583419201 6166705.5789518375 1.0 7.266830623973316 6.171206529444061 19.93051596023028 -9.486255283196433 12.474950729694458 0.9999971040273364 6.719018576708688 0.9732114859617209 0.4472866635857114 0.0 0.0 0.4330834497606228 0.14436114992020757 3.263959165704293e-10 9.486255283196433 5.7190214726813515 STLEPVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STLEPVEK 8 0 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066;P48741 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6;HSPA7 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 12983300.0 2680400.0 4165200.0 6137700.0 False True 3469830.6385830366 3933402.9584949366 5020701.578120196 1.0 1.1336008492049074 1.4469586850413205 21.726433816323883 -6.956813926166672 0.4782256980239652 0.992351491938532 1.6012336548071227 0.9996331737844775 0.003587767740720691 0.08085949077799166 0.025490317182222926 0.004402477352366085 0.025851126967047895 1.1045517646608703e-07 6.956813926166672 0.6088821628685906 STLEPVEK(ub)ALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STLEPVEKALR 11 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;P17066;P48741 P0DMV9;P17066 HSPA1B;HSPA1A;HSPA6;HSPA7 Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 1 9541600.0 2593400.0 4983900.0 1964300.0 True False 2511073.9365553893 6973997.260695157 1449790.902263143 1.0 2.7772966614682253 0.5773589065449501 21.259873077555813 -6.6917230849345115 1.8601705809400744 2.1124355683250164 0.5847731441892604 0.3785681150345289 0.7514084880208188 0.4129701637127328 2.771820316585702 0.3229825146090627 0.839284727145654 2.033653296658669e-07 6.6917230849345115 -1.5276624241357561 STLINSLFLTDLYSPEYPGPSHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STLINSLFLTDLYSPEYPGPSHR 23 0 E7ES33;E7EPK1;Q16181-2;Q16181;G3V1Q4;A0A0U1RRE1;A0A0U1RRH9;A0A5F9ZGZ7 E7ES33 SEPT7 Septin-7 0 23728800.0 11105000.0 7462500.0 5161300.0 False True 10752477.853569672 10442315.166423393 3809400.694318976 1.0 0.9711543058846377 0.35428119417649473 23.358165824038334 -6.916661179152081 0.8491249850180727 1.0153167720845933 0.2620638799773648 0.993201941959022 0.024556074036607253 0.10017649824801934 0.11608988634806544 0.020791634355647747 0.06042422085907346 1.2115429669458172e-07 6.916661179152081 -0.7532528921072285 down STLINSLFLTDLYSPEYPGPSHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STLINSLFLTDLYSPEYPGPSHR 23 0 E7ES33;E7EPK1;Q16181-2;Q16181;G3V1Q4;A0A0U1RRE1;A0A0U1RRH9;A0A5F9ZGZ7 E7ES33 SEPT7 Septin-7 0 7842200.0 1540100.0 1357500.0 4944600.0 False True 2109516.58963757 1297521.1613478102 3776787.3172335667 1.0 0.6150798565517485 1.7903567745264546 21.008481002552802 -6.818491882123506 1.3784907731173 0.7922115855661054 1.8151722677596185 0.8808574453810348 0.16886725744329611 0.1954486485481911 0.7301996684992639 0.09627733969744239 0.22198675794079778 1.5188263318222869e-07 6.818491882123506 1.022960682193513 STLINSLFLTDLYSPEYPGPSHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STLINSLFLTDLYSPEYPGPSHR 23 0 E7ES33;E7EPK1;Q16181-2;Q16181;G3V1Q4;A0A0U1RRE1;A0A0U1RRH9;A0A5F9ZGZ7 E7ES33 SEPT7 Septin-7 0 32873700.0 12462000.0 11330000.0 9081700.0 False True 16132304.662745044 10699475.540129548 7428923.7861111155 1.0 0.6632329207641523 0.46049984434443625 23.943449220994136 -9.349582935336237 0.12016980688531993 1.6330381806953722 8.599798263088724e-13 0.9999102858711058 0.0021074974648115394 0.7961887575191605 0.04473806922030404 0.37884508589928434 0.2112264319695057 4.471127604482296e-10 9.349582935336237 -1.6330381806945122 STLINTLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STLINTLFK 9 0 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4;K7EL40;K7EK18;K7EQD7;K7ER52;K7EIE4;K7ELJ9;K7ER14;K7EJZ2;K7ENQ5;K7EN52;K7EKN4;K7EIR4 Q9UHD8 SEPT9 Septin-9 0 18248600.0 4698100.0 5013000.0 8537500.0 False True 6159254.596465119 4265079.9405209515 7654121.397482795 1.0 0.6924669006163082 1.2427025507072886 22.554324333385036 -6.755012830692161 1.6311038598487286 0.8202657743535526 1.2442416509457956 0.6703388018329488 0.1292735079341195 0.2913764328247227 1.5265955495899943 0.062567773808882 0.1511182636565684 1.7578716790516395e-07 6.755012830692161 0.423975876592243 STLINTLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STLINTLFK 9 0 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4;K7EL40;K7EK18;K7EQD7;K7ER52;K7EIE4;K7ELJ9;K7ER14;K7EJZ2;K7ENQ5;K7EN52;K7EKN4;K7EIR4 Q9UHD8 SEPT9 Septin-9 0 21709800.0 8566700.0 3317900.0 9825200.0 False True 8294754.797674499 4642754.772619927 7251685.370318089 1.0 0.559721762229977 0.8742495163752346 22.983767903439897 -9.951612140939542 6.2871850618679375 1.0000000725103473 0.7169856393025889 0.5191238441549564 0.12840541793330165 1.3050101740933669e-07 2.1805437004978154e-08 0.12432804279919758 0.041442670434864264 1.1178611398559609e-10 9.951612140939542 -0.28301443320775843 STLINTLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STLINTLFK 9 0 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4;K7EL40;K7EK18;K7EQD7;K7ER52;K7EIE4;K7ELJ9;K7ER14;K7EJZ2;K7ENQ5;K7EN52;K7EKN4;K7EIR4 Q9UHD8 SEPT9 Septin-9 0 15108900.0 3607100.0 8557700.0 2944100.0 False True 5472234.414333132 7030511.573384715 2362197.344555129 1.0 1.2847606738063104 0.4316696189709913 22.383698601659155 -6.816690235505233 1.385994752212724 1.1540171294152983 0.41431332278752253 0.876640624041107 0.12455458725600953 0.19781053742466437 0.7475135679190358 0.07063315559901095 0.16297003585725436 1.5251401860693796e-07 6.816690235505233 -0.7397038066277758 down STLINTLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STLINTLFK 9 0 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4;K7EL40;K7EK18;K7EQD7;K7ER52;K7EIE4;K7ELJ9;K7ER14;K7EJZ2;K7ENQ5;K7EN52;K7EKN4;K7EIR4 Q9UHD8 SEPT9 Septin-9 0 20563700.0 4698100.0 8246600.0 7619000.0 False True 6435114.531378652 7882237.94414058 5819549.118230506 1.0 1.2248792007827556 0.9043427416642625 22.617534394907928 -6.718123691469446 1.7659385001710568 1.1370863696895424 0.9048901048553953 0.5036963435884714 0.09465244537113483 0.3589809887357821 2.186805552587193 0.04257408562923439 0.10711863062431823 1.9137108031669858e-07 6.718123691469446 -0.23219626483414701 STLINTLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STLINTLFK 9 0 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4;K7EL40;K7EK18;K7EQD7;K7ER52;K7EIE4;K7ELJ9;K7ER14;K7EJZ2;K7ENQ5;K7EN52;K7EKN4;K7EIR4 Q9UHD8 SEPT9 Septin-9 0 13381800.0 8566700.0 2950100.0 1865000.0 False True 7123590.619157978 2934207.225750995 2254962.8772142935 1.0 0.4119000350553305 0.31654863365531727 22.764173178874174 -13.999999999999998 0.25603760360014105 5.217700483170771 0.28035261030839753 0.9995543584059962 0.006380033831033177 14.245547600011994 0.16011499877622085 31.013409256664346 0.0425748990254803 1.0000000000000041e-14 13.999999999999998 -4.937347872862373 STLINTLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STLINTLFK 9 0 Q9UHD8;Q9UHD8-5;Q9UHD8-2;Q9UHD8-7;Q9UHD8-3;Q9UHD8-8;Q9UHD8-9;Q9UHD8-4;K7EL40;K7EK18;K7EQD7;K7ER52;K7EIE4;K7ELJ9;K7ER14;K7EJZ2;K7ENQ5;K7EN52;K7EKN4;K7EIR4 Q9UHD8 SEPT9 Septin-9 0 10149900.0 3607100.0 2755100.0 3787700.0 False True 4669462.056570993 2601776.2630724576 3098377.465083972 1.0 0.5571897215464398 0.6635405593935284 22.154824923751605 -9.888397427112343 6.596985041362779 1.000000018089737 0.61036514046998 0.947080655225542 0.043417547740528875 1.1529661422201413e-08 1.8991338551751693e-09 0.04203886171231421 0.014012953277677976 1.2930120519555328e-10 9.888397427112343 -0.389634877619757 STLLGVLTHGELDNGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STLLGVLTHGELDNGR 16 0 O00178;F5H716 O00178 GTPBP1 GTP-binding protein 1 0 5091750.0 2433000.0 906750.0 1752000.0 False True 2355765.7467568675 1268820.0036387842 1293098.641126622 1.0 0.5386019409550977 0.5489079900693875 21.16776465654242 -10.020436121262343 5.119138156681425 1.0000044124042158 0.5437549655098133 0.9996174536811568 0.004207426940802769 5811322.686572625 1.0005832746256453 302.2442157443253 0.0014403141515446983 9.540340577940772e-11 10.020436121262343 -0.4562494468944025 STLLGVLTHGELDNGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STLLGVLTHGELDNGR 16 0 O00178;F5H716 O00178 GTPBP1 GTP-binding protein 1 0 2724650.0 983850.0 1740800.0 0.0 False True 1347605.9325465367 1663885.6999442088 0.0 1.0 1.234697517841886 0.0 20.361967254066435 -6.90333807710049 1.291780248408086 1.1223668423080946 1.4446905097538511e-21 0.9491430705052007 0.12073319795406047 0.1323389879595002 0.44304696518717346 0.07642163360075173 0.15178356067490664 1.2492861431821879e-07 6.90333807710049 -1.1223668423080946 down STLLLLLTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STLLLLLTGK 10 0 Q8NE71-2;Q8NE71;H0YGW7 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 33123900.0 8329900.0 12696000.0 12098000.0 False True 10920579.566866355 10801806.288620379 10846215.012210472 1.0 0.9891239034046928 0.9931904205083117 23.380546087873714 -10.246066212118597 5.541518098261688 1.0000005870212063 0.9911571619940336 0.8631037956199241 0.0016601486556957609 1.2040941958208192e-08 1.638403422192131e-09 0.0016075387401074967 0.0005358106746446783 5.6745808470000536e-11 10.246066212118597 -0.008843425027172724 STLLLLLTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STLLLLLTGK 10 0 Q8NE71-2;Q8NE71;H0YGW7 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 40499440.0 18582000.0 9782440.0 12135000.0 False True 17992124.58127256 13688619.306750664 8956479.457803415 1.0 0.7608117232024237 0.49779999117646917 24.10086221999981 -6.9699046306706345 0.26045379279455894 1.0734328461002747 0.17737108027864507 0.9999816286629885 0.0008790729844389274 0.07633367255471724 0.00914080704837529 0.005474384137310238 0.024798722679800586 1.0717546324243165e-07 6.9699046306706345 -0.8960617658216297 down STLLLLLTGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STLLLLLTGK 10 0 Q8NE71-2;Q8NE71;H0YGW7 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 72391000.0 20306000.0 24965000.0 27120000.0 False True 30805686.567449868 20509800.697564706 21759720.112881724 1.0 0.6657796979352482 0.7063540059475136 24.876693353618954 -10.432023282443671 9.10649323011212 1.0000021113538846 0.6860668520774053 0.9876267987926074 0.016564391882761598 7.100503814992194e-07 4.42873508368689e-08 0.016038511348840098 0.005346134491832414 3.698083538940924e-11 10.432023282443671 -0.31393525927647936 STLLLLLTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STLLLLLTGK 10 0 Q8NE71-2;Q8NE71;H0YGW7 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 76448300.0 8329900.0 26068400.0 42050000.0 False True 11409689.137083301 24916611.891329072 32118656.046934325 1.0 2.183811635178221 2.8150334037185636 23.443756149396606 -9.10989402868496 0.2041228414196915 9.559984458562107e-17 3.445414237323995 0.9995202650857048 0.01647848408828529 0.5620743678533997 0.0710849539483166 0.710693043858852 0.33998319161491114 7.764365502227806e-10 9.10989402868496 3.445414237323995 STLLLLLTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STLLLLLTGK 10 0 Q8NE71-2;Q8NE71;H0YGW7 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 34286600.0 18582000.0 8034400.0 7670200.0 False True 15451756.322176995 7991117.092496461 9274003.357002174 1.0 0.5171656170261553 0.6001908885717894 23.881267495434088 -10.791063423044083 7.157035031360232 1.0141055143886064 0.5586782527989723 0.9741420832437578 0.03389492517380313 0.00746915327658463 0.00021804806813470262 0.032131653503023334 0.010939540059923846 1.617843755413424e-11 10.791063423044083 -0.4554272615896341 STLLLLLTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STLLLLLTGK 10 0 Q8NE71-2;Q8NE71;H0YGW7 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 68270000.0 20306000.0 23145000.0 24819000.0 False True 26286517.29110101 21856960.403909832 20302196.664445195 1.0 0.8314893967071572 0.7723425830670336 24.647819675711403 -13.999999997257513 0.14593821689267017 1.8101562125849875 0.7041293719406154 0.9995803539542648 0.00197577931460822 11.94480935664641 0.1200883409907434 2.748019370310652 0.06125761660857101 1.00000000631481e-14 13.999999997257513 -1.106026840644372 STLLQVLQHQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STLLQVLQHQR 11 0 O95801 O95801 TTC4 Tetratricopeptide repeat protein 4 0 4181000.0 1183700.0 1176200.0 1821100.0 False True 1621345.8782897135 1124231.5948267342 1390993.6867318002 1.0 0.6933940560620148 0.8579253232500262 20.628760460096075 -10.058372929737137 4.835916438887056 1.0000062701410124 0.7756596902157239 0.7125516267548249 0.06716960856753823 93126297.227388 3.3600195020660895 6501.926258292182 0.022993943617984184 8.742327470139383e-11 10.058372929737137 -0.2243465799252885 STLMDTLFNTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STLMDTLFNTK 11 0 D6RDU5;D6RGI3;D6RER5;Q9NVA2;Q9NVA2-2;D6RDP1;D6R9Y6;Q14141;B1AMS2;Q14141-2;Q14141-4;Q14141-3 D6RDU5;Q14141 SEPT11;SEPT6 Septin-11;Septin-6 0 9692200.0 2461800.0 3070800.0 4159600.0 False True 3227443.64010511 2612648.6098846467 3729204.493700668 1.0 0.8095102196113203 1.1554669607117343 21.621960471719287 -6.75723480200347 1.6230263260681743 0.888972425425956 1.156554590285466 0.6795207650693731 0.08009154346544343 0.2875877804393839 1.4924610800653488 0.03894858312197992 0.09385145757358024 1.7489008869225907e-07 6.75723480200347 0.2675821648595099 STLMDTLFNTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STLMDTLFNTK 11 0 D6RDU5;D6RGI3;D6RER5;Q9NVA2;Q9NVA2-2;D6RDP1;D6R9Y6;Q14141;B1AMS2;Q14141-2;Q14141-4;Q14141-3 D6RDU5;Q14141 SEPT11;SEPT6 Septin-11;Septin-6 0 9611000.0 3543200.0 1467000.0 4600800.0 False True 3430723.055449621 2052780.7503039355 3395712.4589585466 1.0 0.5983522182133422 0.9897949802635743 21.710081238601944 -10.790708372704769 10.072636614294217 1.0016054379391994 0.7940735997037175 0.2695397616677171 0.15980583842145996 0.005798339259161536 0.00012047901025634339 0.1557221721563927 0.05157711256941897 1.6191669378724374e-11 10.790708372704769 -0.20753183823548194 STLMDTLFNTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STLMDTLFNTK 11 0 D6RDU5;D6RGI3;D6RER5;Q9NVA2;Q9NVA2-2;D6RDP1;D6R9Y6;Q14141;B1AMS2;Q14141-2;Q14141-4;Q14141-3 D6RDU5;Q14141 SEPT11;SEPT6 Septin-11;Septin-6 0 14101400.0 2461800.0 4635400.0 7004200.0 False True 3371993.987643505 4430592.700782048 5349952.216027059 1.0 1.3139384936680558 1.586584150396376 21.68517053324218 -6.9727754148475505 0.17994607834312884 0.7890797704088678 2.1188152509885576 0.9999967198512952 0.00043403169227364713 0.07541207071723287 0.005674556227216876 0.010504244636756607 0.03060185592095122 1.0646934570090556e-07 6.9727754148475505 1.3297354805796897 STLMGHMLYLLGNINK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STLMGHMLYLLGNINK 16 0 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;E9PHZ9;E9PS53 Q9Y450 HBS1L HBS1-like protein 0 216238000.0 75496000.0 72551000.0 68191000.0 False True 73099420.80442117 101520992.64846675 50329731.41385022 1.0 1.3888070730421793 0.6885106729984678 26.12335663939199 -6.756003171821902 1.6274447337189266 1.2269609203027558 0.686440141600663 0.6744524183994416 0.16345343076950555 0.28969269195452285 1.5112359937229962 0.07927976970791965 0.1912865963123138 1.753867692615517e-07 6.756003171821902 -0.5405207787020928 STLMGHMLYLLGNINK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STLMGHMLYLLGNINK 16 0 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;E9PHZ9;E9PS53 Q9Y450 HBS1L HBS1-like protein 0 88130000.0 25902000.0 27546000.0 34682000.0 False True 39295227.68984966 22630201.082119673 27827087.498339407 1.0 0.5759020220148838 0.7081543773705481 25.227850775518494 -10.78716770704994 10.46208118271666 1.0021241250895727 0.6420281996927171 0.9071368760985176 0.053991797983769255 0.0026838746998964326 5.4598520591520286e-05 0.05245024686706251 0.017425777868577796 1.6324214507013556e-11 10.78716770704994 -0.36009592539685564 STLMGHMLYLLGNINK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STLMGHMLYLLGNINK 16 0 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;E9PHZ9;E9PS53 Q9Y450 HBS1L HBS1-like protein 0 134062000.0 75496000.0 24801000.0 33765000.0 False True 62778269.03988133 24667392.090386953 40825105.38827917 1.0 0.3929288345735756 0.6503063243483838 25.903761914826266 -10.3580412986365 5.876002053128288 1.000080839676091 0.5216175794609993 0.8216278273358778 0.10507392020444854 0.00011129501854592207 1.215922071187637e-05 0.1017544542442377 0.033912461922712626 4.38488998284072e-11 10.3580412986365 -0.47846326021509167 STLMGHMLYLLGNINK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STLMGHMLYLLGNINK 16 0 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;E9PHZ9;E9PS53 Q9Y450 HBS1L HBS1-like protein 0 49907200.0 25902000.0 14601000.0 9404200.0 False True 33530649.604752235 13788441.514689457 7692732.095240559 1.0 0.4112190392140583 0.22942389085567502 24.998977097610943 -13.999999999999796 0.16457514473514054 3.929454279737351 0.05943452193045583 0.9995250891305064 0.007167251515401458 12.043327532904462 0.12834025419119818 11.259992173287516 0.1558689609228287 1.0000000000004703e-14 13.999999999999796 -3.870019757806895 STLMGHMLYLLGNINKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STLMGHMLYLLGNINKR 17 1 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;E9PHZ9;E9PS53 Q9Y450 HBS1L HBS1-like protein 0 25746000.0 3526800.0 13441000.0 8778200.0 False True 3414843.664472718 18808061.393889014 6478926.079644817 1.0 5.507737173904606 1.8972833652826155 21.703388101089118 -6.590813668184739 2.2253376616029454 4.0493290084845155 1.9077753839515637 0.0 1.95293853854918 0.6672231395783889 6.230181055015533 0.732200893368949 2.1768605500077083 2.565584551280792e-07 6.590813668184739 -2.1415536245329516 STLMGHMLYLLGNINKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STLMGHMLYLLGNINKR 17 1 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;E9PHZ9;E9PS53 Q9Y450 HBS1L HBS1-like protein 0 135481600.0 37365500.0 39343100.0 58773000.0 False True 56686195.28395794 32322016.41595667 47156490.78887899 1.0 0.5701920238965786 0.8318866798637333 25.756494104489512 -10.289196311898037 6.014505409447313 1.0000158665096142 0.7010393518801556 0.6350513488302971 0.10683639592212175 2.2731353137729612e-05 2.686419707879466e-06 0.10344938128815406 0.03448129851459964 5.1381134358637683e-11 10.289196311898037 -0.2989765146294585 STLMGHMLYLLGNINKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STLMGHMLYLLGNINKR 17 1 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;E9PHZ9;E9PS53 Q9Y450 HBS1L HBS1-like protein 0 7504400.0 1562700.0 2305100.0 3636600.0 False True 2140472.420379602 2203253.060053651 2777709.9781279787 1.0 1.0293302726427633 1.297708838329889 21.029497816100346 -6.92768480061768 0.7655442231740827 0.99554941893785 1.349694370228795 0.9960636641593409 0.008404947544190532 0.09385743862900361 0.08369694471960182 0.007554458712463928 0.024599910050812534 1.1811775919118492e-07 6.92768480061768 0.3541449512909449 STLMGHMLYLLGNINKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STLMGHMLYLLGNINKR 17 1 Q9Y450;Q9Y450-4;J3QT46;B7Z524;H0YDX7;E9PHZ9;E9PS53 Q9Y450 HBS1L HBS1-like protein 0 126405700.0 37365500.0 45193700.0 43846500.0 False True 48370376.33411978 42678630.86654485 35866886.90308217 1.0 0.8823299321001963 0.7415052274005604 25.52762042658196 -6.968738863254931 0.2867267682251142 1.0286160099309114 0.5908880974582905 0.9999707964393549 0.000571020687142369 0.07671421413709927 0.010488482071594838 0.002504473415390988 0.012819759616203203 1.0746353851689825e-07 6.968738863254931 -0.4377279124726209 STLNEIYFGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STLNEIYFGK 10 0 P47756-2;B1AK88;B1AK87;P47756 P47756-2 CAPZB F-actin-capping protein subunit beta 0 34373100.0 7250100.0 14355000.0 12768000.0 False True 9504951.310068268 12213289.955351746 11446889.83930429 1.0 1.2849397705398689 1.204308098577948 23.180247805887326 -10.079723948787274 4.32048126210693 0.9999756936703112 1.2446239345512076 0.9246549997351279 0.03291774235105235 22867593.646468457 0.037563095741086905 5880.710600600387 0.011268618750199588 8.322926343422959e-11 10.079723948787274 0.24464824088089632 STLNEIYFGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STLNEIYFGK 10 0 P47756-2;B1AK88;B1AK87;P47756 P47756-2 CAPZB F-actin-capping protein subunit beta 0 36825600.0 13103000.0 5571600.0 18151000.0 False True 12687052.43721959 7796368.935510174 13396708.581671987 1.0 0.6145138103660881 1.0559354623908153 23.596853593268538 -6.675956277396669 1.9165908204947915 0.7552154575718025 1.0541936351996486 0.30560653281478267 0.16352502250831782 0.44754733515885525 3.1749472390438855 0.06855713349433652 0.18173464998186797 2.108840446789503e-07 6.675956277396669 0.29897817762784606 STLNEIYFGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STLNEIYFGK 10 0 P47756-2;B1AK88;B1AK87;P47756 P47756-2 CAPZB F-actin-capping protein subunit beta 0 32389100.0 7250100.0 13125000.0 12014000.0 False True 9930657.896585498 12545094.101429082 9176540.636096781 1.0 1.263269184385308 0.9240617018185665 23.243457867410218 -6.69953566021526 1.8323039310091278 1.163558926503107 0.9250747956663925 0.4153309510921941 0.11113974735345418 0.3965672022482551 2.5880777724829236 0.048393096682739854 0.12453590803997547 1.9973967541032838e-07 6.69953566021526 -0.2384841308367145 STLNEIYFGK(ub)TK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STLNEIYFGKTK 12 1 P47756-2;B1AK88;B1AK87;P47756 P47756-2 CAPZB F-actin-capping protein subunit beta 1 25337900.0 10116000.0 8521500.0 6700400.0 True False 13856158.574620899 8144991.953167855 5117903.519069653 1.0 0.587824678052279 0.36935947950564485 23.72402401017909 -10.214653517103768 0.13648601094313967 1.7807393727414416 3.551333315126134e-11 0.9997870630871488 0.0038155337645192165 1.879135858212183 0.06696074519370215 0.7251777389283673 0.21890901058627807 6.100233836836524e-11 10.214653517103768 -1.7807393727059282 STLNEIYFGK(ub)TK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STLNEIYFGKTK 12 1 P47756-2;B1AK88;B1AK87;P47756 P47756-2 CAPZB F-actin-capping protein subunit beta 1 14174000.0 0.0 14174000.0 0.0 True False 0.0 14097641.848681288 0.0 0.0 STLTDSLVCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STLTDSLVCK 10 0 P13639 P13639 EEF2 Elongation factor 2 0 103105000.0 10252000.0 49374000.0 43479000.0 False True 13440471.28050923 42007591.65834463 38980210.160018116 1.0 3.1254552598361753 2.900211558544489 23.680080390284537 -9.890823867466798 7.055234956411496 0.9999999700301568 3.0128334091903426 0.9906955411536477 0.0919553559901215 4.346056061658244e-08 6.769768208959406e-09 0.08903539058604039 0.029678463528687363 1.2858080267038718e-10 9.890823867466798 2.0128334391601856 STLTDSLVCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STLTDSLVCK 10 0 P13639 P13639 EEF2 Elongation factor 2 0 31100300.0 14848000.0 5350300.0 10902000.0 False True 14376658.367384275 7486702.691445904 8046439.14701053 1.0 0.520754023649242 0.5596877202886834 23.777225046731562 -10.660281510710073 9.386125931849456 1.0002977890542386 0.5402208719689627 0.9946508502570935 0.015894615094490624 9.910837798401902e-05 3.5871043274188303e-06 0.015399224198810112 0.00512996496294494 2.186343971204445e-11 10.660281510710073 -0.46007691708527587 STLTDSLVCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STLTDSLVCK 10 0 P13639 P13639 EEF2 Elongation factor 2 0 182555000.0 13243000.0 158730000.0 10582000.0 False True 20090599.19298428 130403391.33684947 8490463.06174463 1.0 6.49076665579924 0.42260875249104246 24.26001725664789 -6.668429725815451 1.9432406964026303 4.509458040125583 0.4474401720496511 0.2720457018546528 2.333203710436192 0.4646931686810906 3.381595186159399 0.9672046137364713 2.589147220908839 2.1457062893743235e-07 6.668429725815451 -4.062017868075932 STLTDSLVCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STLTDSLVCK 10 0 P13639 P13639 EEF2 Elongation factor 2 0 78330000.0 10252000.0 28525000.0 39553000.0 False True 14042441.449882707 27264671.180439223 30211396.01960512 1.0 1.9415905188386566 2.1514347150692568 23.74329045180743 -10.721118855664306 0.30049003675196706 2.3961879889565275e-13 2.215790191128813 0.9991589718462714 0.014520943419302873 2.4061313498576977 0.14954162880304403 1.8235875062079852 0.07519708218828443 1.900558072978263e-11 10.721118855664306 2.215790191128573 STLTDSLVCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STLTDSLVCK 10 0 P13639 P13639 EEF2 Elongation factor 2 0 21896300.0 14848000.0 2751000.0 4297300.0 False True 12346769.877929376 2736179.816969256 5195845.561529751 1.0 0.22161098360311618 0.42082630622424166 23.55763032216584 -10.3857744187024 5.144326626203563 1.0004698431420176 0.32121864491821756 0.939318040252567 0.08132931489442924 0.00043854792540407527 5.236212510066575e-05 0.07879880396573682 0.02624892351202738 4.1136333602052826e-11 10.3857744187024 -0.6792511982238001 STLTDSLVCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STLTDSLVCK 10 0 P13639 P13639 EEF2 Elongation factor 2 0 37550000.0 13243000.0 12449000.0 11858000.0 False True 17143324.558556624 11756202.206449503 9699965.673354728 1.0 0.6857597641748966 0.5658159034569088 24.03114357874034 -13.999999999999998 0.13347006329128377 2.4947359406257146 0.4050171842239974 0.9996301991895076 0.0035205720853306436 11.93293531023031 0.11393976369131041 4.6656742362308545 0.14321414998422544 1.0000000000000041e-14 13.999999999999998 -2.0897187564017172 STLTDSLVCK(ub)AGIIASAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STLTDSLVCKAGIIASAR 18 1 P13639 P13639 EEF2 Elongation factor 2 1 17354100.0 0.0 6877100.0 10477000.0 True False 0.0 9623161.893602725 7732759.396737232 0.0 STLTDSLVCK(ub)AGIIASAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STLTDSLVCKAGIIASAR 18 1 P13639 P13639 EEF2 Elongation factor 2 1 123357000.0 11066000.0 22301000.0 89990000.0 True False 16787931.032965656 18321212.311491724 72203437.0559819 1.0 1.0913323551017238 4.300913371290332 24.00092110577871 -6.91298972351971 0.875142276472936 0.9097737198301683 4.743337918590801 0.9920014439968013 0.13728139247914992 0.10247368982092407 0.12829400959424436 0.11408279296058978 0.32183562816152267 1.2218285713051246e-07 6.91298972351971 3.833564198760633 up STLTDSLVCK(ub)AGIIASAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STLTDSLVCKAGIIASAR 18 1 P13639 P13639 EEF2 Elongation factor 2 1 14607500.0 1757400.0 4258000.0 8592100.0 True False 2407158.271949262 4069867.48067696 6562822.939854095 1.0 1.6907353073137457 2.72637782747026 21.19889957222901 -6.965264596019193 0.3534815793255996 0.9038427637750988 3.5484043581404667 0.9999184965573434 0.006404984689730753 0.07787128102985483 0.014543976553718585 0.014094917719397165 0.08881459670905968 1.083266727423742e-07 6.965264596019193 2.644561594365368 STLTDSLVCK(ub)AGIIASAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STLTDSLVCKAGIIASAR 18 1 P13639 P13639 EEF2 Elongation factor 2 1 21362900.0 0.0 5921900.0 15441000.0 True False 0.0 5889997.549294884 18669641.708882503 0.0 STLTDSLVCK(ub)AGIIASAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STLTDSLVCKAGIIASAR 18 1 P13639 P13639 EEF2 Elongation factor 2 1 82073000.0 11066000.0 21440000.0 49567000.0 True False 14325155.143471096 20246845.152725294 40546314.6003689 1.0 1.4133770245380621 2.8304276075396286 23.772047427871158 -6.948420593622679 0.5759211445409833 0.9827897265535976 3.330615245139671 0.9990714475068304 0.023884717482790044 0.0841262002262494 0.038635227085540846 0.025136778279878615 0.11824549197653428 1.1261063472907401e-07 6.948420593622679 2.3478255185860735 up STMDNPTTTQYASLMHSFILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STMDNPTTTQYASLMHSFILK 21 0 Q9NP97;B1AKR6 Q9NP97 DYNLRB1 Dynein light chain roadblock-type 1 0 9127500.0 2182100.0 3842200.0 3103200.0 False True 2860754.2314864616 3268958.7367782984 2782110.631996322 1.0 1.1426912178610085 0.9725094876642807 21.44796412981441 -6.684249566293379 1.8863606206889185 1.0899313029622346 0.9731265495349045 0.3439285621943009 0.06041979437668059 0.4291165487020757 2.9556215806510404 0.02566458907025747 0.06733295259928139 2.0689520887131872e-07 6.684249566293379 -0.1168047534273301 STMDNPTTTQYASLMHSFILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STMDNPTTTQYASLMHSFILK 21 0 Q9NP97;B1AKR6 Q9NP97 DYNLRB1 Dynein light chain roadblock-type 1 0 13146900.0 5191100.0 3177100.0 4778700.0 False True 5026311.371964477 4445732.598357623 3527015.112072946 1.0 0.8844920796500634 0.7017104295897315 22.261068615965478 -6.9643534029350755 0.3689870628330489 1.0142184519143564 0.5656318765877086 0.9998991799534664 0.0012330536221006026 0.0781811422432526 0.01563821406485615 0.0024129725939025216 0.01553201478295003 1.0855419148749325e-07 6.9643534029350755 -0.4485865753266478 STMDNPTTTQYASLMHSFILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STMDNPTTTQYASLMHSFILK 21 0 Q9NP97;B1AKR6 Q9NP97 DYNLRB1 Dynein light chain roadblock-type 1 0 13200100.0 2182100.0 4480900.0 6537100.0 False True 2988881.3390352195 4282919.021645228 4993171.615800586 1.0 1.4329505041600985 1.670582083868318 21.5111741913373 -10.406556382629114 0.11712844150806882 5.602196090210831e-17 2.1748755737844903 0.9998539689709687 0.003354700290807028 2.23088990688701 0.06158707719101201 0.9422074030752441 0.3026898710452588 3.9214223284817557e-11 10.406556382629114 2.1748755737844903 STMDNPTTTQYASLMHSFILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STMDNPTTTQYASLMHSFILK 21 0 Q9NP97;B1AKR6 Q9NP97 DYNLRB1 Dynein light chain roadblock-type 1 0 11958900.0 5191100.0 2837700.0 3930100.0 False True 4316629.654722469 2822412.74686065 4751865.73927072 1.0 0.6538463969854075 1.1008277566902445 22.041473891399754 -6.699977383639078 1.8313094746456102 0.7850445259996829 1.0994822717447224 0.4173395726714899 0.146116496054184 0.3955515625814412 2.57909279014965 0.06365890197791158 0.16369663666274806 1.9953662231453158e-07 6.699977383639078 0.31443774574503947 STNGDTFLGGEDFDQALLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STNGDTFLGGEDFDQALLR 19 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 17460100.0 2164400.0 7220100.0 8075600.0 False True 2837549.360079414 6142889.223729372 7240014.378625138 1.0 2.1648572215700423 2.5515025326017633 21.436214058088048 -10.09352158910237 0.26305726514311006 1.5455034006268407e-13 2.740217122488315 0.9990498546940159 0.02032633229569271 1.5626125120969965 0.12083508472316842 1.2942232279152712 0.16270253043311259 8.062661202687672e-11 10.09352158910237 2.7402171224881604 STNGDTFLGGEDFDQALLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STNGDTFLGGEDFDQALLR 19 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 29080900.0 10670000.0 4887900.0 13523000.0 False True 10331286.690462708 6839663.96006177 9980920.618695967 1.0 0.6620340878136488 0.9660868890522435 23.300516607315778 -10.317389998406185 7.915757289184048 1.000000734508063 0.8140604891676806 0.3327267942014721 0.12412903631640501 1.6090481261597456e-06 1.3880485859144797e-07 0.1201878980809776 0.04006247420285103 4.8151520059231975e-11 10.317389998406185 -0.18594024534038245 STNGDTFLGGEDFDQALLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STNGDTFLGGEDFDQALLR 19 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 21609900.0 2164400.0 9725200.0 9720300.0 False True 2964637.170710701 9295508.50706425 7424565.335862449 1.0 3.13546244339771 2.504375715589705 21.49942411961094 -10.030504229255682 5.2316116834577535 0.9999845820500507 2.8199190794987765 0.917275352519141 0.25764007777975934 4.6332235050510674e-05 8.586214591623722e-06 0.2494610388522376 0.08315297754383186 9.321713926062955e-11 10.030504229255682 1.8199344974487257 STNGDTFLGGEDFDQALLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STNGDTFLGGEDFDQALLR 19 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 14919300.0 10670000.0 2116000.0 2133300.0 False True 8872577.76114672 2104600.6880068853 2579363.1667352547 1.0 0.23720284506527448 0.29071181297845167 23.080921882750054 -10.185856045958735 8.045369625584476 1.0000002074024843 0.26395732902186386 0.996051879344472 0.02184494467504029 8.125575280040083e-08 8.22678648867112e-09 0.021151282404212962 0.007050425577104454 6.518444227991379e-11 10.185856045958735 -0.7360428783806204 STNK(ub)GTAYTFFTPGNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STNKGTAYTFFTPGNLK 17 1 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 1 9138200.0 2855500.0 2404900.0 3877800.0 True False 2764853.7155216746 3365189.1113878204 2862087.8484936156 1.0 1.2171309796593974 1.0351679122935424 21.39877172086034 -13.641448707841302 10.898263145378309 0.9907142332927694 1.113534501710934 0.0 0.09960528041389265 0.0 0.0 0.0 0.02749650355515514 2.283238569642368e-14 13.641448707841302 0.12282026841816451 STNLNCSVIADVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STNLNCSVIADVR 13 0 Q96EL3 Q96EL3 MRPL53 39S ribosomal protein L53, mitochondrial 0 3921000.0 0.0 2081500.0 1839500.0 False True 0.0 1770948.3136234512 1649166.1857299663 0.0 STNLNCSVIADVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STNLNCSVIADVR 13 0 Q96EL3 Q96EL3 MRPL53 39S ribosomal protein L53, mitochondrial 0 4138800.0 0.0 1959800.0 2179000.0 False True 0.0 1873209.555808056 1664365.0779136722 0.0 STNMK(ub)CLTPEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STNMKCLTPEK 11 1 P53618 P53618 COPB1 Coatomer subunit beta 1 1378000.0 0.0 0.0 1378000.0 True False 0.0 0.0 1105637.6960011455 0.0 STNQQTATDVSTSSNIEESVNHMDGESLK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STNQQTATDVSTSSNIEESVNHMDGESLKLR 31 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 69211000.0 20780000.0 32434000.0 15997000.0 True False 27242781.233806275 27594973.626741804 14341783.894059425 1.0 1.0129279162033018 0.5264434556433002 24.699370660784535 -6.900794510929712 0.9562174827924151 1.0197876711693945 0.4745441711007248 0.9869578537766062 0.025849142938300252 0.1108232888233284 0.17413390463156644 0.02024371477659569 0.05288459387836152 1.2566244025163997e-07 6.900794510929712 -0.5452435000686697 STNQQTATDVSTSSNIEESVNHMDGESLK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STNQQTATDVSTSSNIEESVNHMDGESLKLR 31 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 141323000.0 42882000.0 56040000.0 42401000.0 True False 41520734.38242005 78417064.24473925 31294906.097265985 1.0 1.8886242117610803 0.7537175476962735 25.307328625260553 -6.697834241841766 1.8381602317877368 1.5529821458826516 0.7571904009737206 0.4073201020668341 0.37525398420469036 0.40014422970644203 2.626880287270093 0.162940849746726 0.4202322069661098 2.0052372247603786e-07 6.697834241841766 -0.795791744908931 STNQQTATDVSTSSNIEESVNHMDGESLK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STNQQTATDVSTSSNIEESVNHMDGESLKLR 31 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 258796600.0 112487600.0 75274000.0 71035000.0 True False 170651913.1451136 61840766.58155354 56994901.11425342 1.0 0.36237956810344896 0.3339833703814846 27.34648134739736 STNQQTATDVSTSSNIEESVNHMDGESLK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 STNQQTATDVSTSSNIEESVNHMDGESLKLR 31 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 114105100.0 25477300.0 51903700.0 36724100.0 True False 34896946.3081444 49610422.91141674 28050623.936580762 1.0 1.421626479100793 0.803813138516197 25.05659746171103 -6.722986742654581 1.7484516812864488 1.2556983456018282 0.8046063952319009 0.5265268798075011 0.17736151421444535 0.34959710392349025 2.090212609005567 0.08049225119511452 0.20136816488589204 1.892401385521979e-07 6.722986742654581 -0.45109195036992733 STNQQTATDVSTSSNIEESVNHMDGESLK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 STNQQTATDVSTSSNIEESVNHMDGESLKLR 31 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 170227100.0 54373000.0 84669000.0 31185100.0 True False 45213558.63231777 84212871.29151928 37705760.226389 1.0 1.8625579104787733 0.8339480759083108 25.430252136815337 -6.6843126016914685 1.8868200639615007 1.543640088244362 0.8377495303734297 0.34381133941553643 0.36523573978427365 0.42903876590907086 2.95676086805187 0.15512449881886353 0.4068457879149533 2.0686518137620422e-07 6.6843126016914685 -0.7058905578709322 STNQQTATDVSTSSNIEESVNHMDGESLK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STNQQTATDVSTSSNIEESVNHMDGESLKLR 31 1 Q14149;H0YHQ4;H0YIR5 Q14149 MORC3 MORC family CW-type zinc finger protein 3 1 250124900.0 112487600.0 87805300.0 49832000.0 True False 145617415.66209278 82918857.86793807 40763087.31949848 1.0 0.5694295389800931 0.2799327754455538 27.11760766948981 -8.254258485149036 0.22931204482366524 1.2339230954541962 2.2144470886875816e-09 0.9996197667107717 0.005768766297573863 0.09102999654690891 0.05054370427167864 0.10307348165895391 0.10930567201003824 5.568542195310528e-09 8.254258485149036 -1.2339230932397491 down STNTSQTGLVGTK(ub)HSTSETEQLLCGRPPDLTALSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STNTSQTGLVGTKHSTSETEQLLCGRPPDLTALSR 35 2 Q96R06 Q96R06 SPAG5 Sperm-associated antigen 5 1 71149800.0 8170900.0 16841000.0 46137900.0 True False 10577391.122518348 15903783.545571212 37741275.61483162 1.0 1.5035639092245947 3.5681081636930037 23.334480499722744 -6.944308274679644 0.6181835779235438 0.9773732537100471 4.203334560007042 0.9986754954700792 0.04043747001395043 0.08585496568600226 0.046063917131869254 0.04079137203660693 0.17460422833927744 1.136820051879444e-07 6.944308274679644 3.225961306296995 up STPK(ub)EDDSSASTSQSTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STPKEDDSSASTSQSTR 17 1 E7EX17;P23588-2;P23588;F8VX11 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 5004700.0 1808400.0 1766100.0 1430200.0 True False 1750993.3318681114 2471312.94008983 1055587.7149196898 1.0 1.4113776992247136 0.6028507908670888 20.739742159035607 -6.7683757305176595 1.5805391385631073 1.236443217686123 0.5985650198679984 0.7243620881738071 0.1733048606031691 0.2690610110377246 1.3262270259402826 0.086438718051222 0.20607920790715387 1.7046070075902517e-07 6.7683757305176595 -0.6378781978181247 STPK(ub)EDDSSASTSQSTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STPKEDDSSASTSQSTR 17 1 E7EX17;P23588-2;P23588;F8VX11 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 7496000.0 2325000.0 1611900.0 3559100.0 True False 3527194.980267951 1324243.8511678164 2855642.3249910553 1.0 0.3754382330934304 0.8096071640400555 21.75008989821864 -10.348815808406993 5.736527774148944 1.000074914730267 0.5925226985668299 0.5401099098886617 0.17724872383148826 0.00016985587398350068 1.9281218625305136e-05 0.17165172233097065 0.057206779627988494 4.4790322718947564e-11 10.348815808406993 -0.40755221616343706 STPK(ub)EDDSSASTSQSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STPKEDDSSASTSQSTR 17 1 E7EX17;P23588-2;P23588;F8VX11 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 2503800.0 0.0 1195000.0 1308800.0 True False 0.0 1142200.9486634491 999688.3955821089 0.0 STPK(ub)EDDSSASTSQSTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STPKEDDSSASTSQSTR 17 1 E7EX17;P23588-2;P23588;F8VX11 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 1 6248500.0 2325000.0 1941500.0 1982000.0 True False 3009758.3326016893 1833453.8182843386 1621296.3370373673 1.0 0.6091697789900188 0.5386799064481331 21.52121622031109 -13.999999999999998 0.24090363524961456 3.5982953920084424 0.5077791671034542 0.9995264678402835 0.004415366347670378 13.655469676922332 0.15534069728011987 17.07776278968903 0.03426207345875513 1.0000000000000041e-14 13.999999999999998 -3.090516224904988 STPKEDDSSASTSQSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STPKEDDSSASTSQSTR 17 1 E7EX17;P23588-2;P23588;F8VX11 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 2527170.0 554520.0 689750.0 1282900.0 False True 726981.0899793195 586841.9886244413 1150157.814445759 1.0 0.807231435196114 1.582101419554775 19.471558312105927 -6.840860134359283 1.2784999934517953 0.897464237896757 1.6080075340959974 0.9259062759541306 0.08965798259739444 0.16779726206033205 0.5324264721083478 0.05498282203645103 0.12669289466994807 1.4425798632304166e-07 6.840860134359283 0.7105432961992404 STPKEDDSSASTSQSTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STPKEDDSSASTSQSTR 17 1 E7EX17;P23588-2;P23588;F8VX11 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 19271200.0 1042900.0 16823000.0 1405300.0 False True 1582155.546202774 13820804.211301068 1127541.8390351282 1.0 8.735426958791415 0.7126618123870729 20.59346001155209 -6.65447025825317 1.9928195684669971 6.001664466776559 0.7464012876973931 0.21237920101599095 3.2979587074475103 0.49758538759112747 3.7927111662361312 1.3399000578083782 3.653441153385954 2.2157958352480504e-07 6.65447025825317 -5.255263179079165 STPKEDDSSASTSQSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STPKEDDSSASTSQSTR 17 1 E7EX17;P23588-2;P23588;F8VX11 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 4125430.0 554520.0 2794500.0 776410.0 False True 759541.02933954 2671029.749824272 593037.9486658807 1.0 3.516636556351498 0.7807846130202574 19.53476837362882 -6.6648475979889605 1.955057002353085 2.6134409392850997 0.7919458529269403 0.25647866810465714 1.0703044629245344 0.47318527844315605 3.481523572877482 0.44145576232755 1.1876915523272127 2.1634775950592171e-07 6.6648475979889605 -1.8214950863581594 STPKEDDSSASTSQSTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STPKEDDSSASTSQSTR 17 1 E7EX17;P23588-2;P23588;F8VX11 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 3850570.0 1042900.0 794870.0 2012800.0 False True 1350054.608632389 750634.7857531144 1646491.0530720549 1.0 0.5560032764256185 1.2195736694976784 20.36458633364454 -6.726384338758626 1.7362234558434986 0.7317311779205862 1.218936934497346 0.5424467595101328 0.18670569518073893 0.3430901694745077 2.024399851993065 0.08527343341696829 0.21248728869211597 1.8776544084342577e-07 6.726384338758626 0.4872057565767598 STPVNVPISQK(ub)FTDLFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STPVNVPISQKFTDLFEK 18 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 11601000.0 3459100.0 4965200.0 3176700.0 True False 3349292.7639156124 6947830.253175949 2344626.971042776 1.0 2.0744171211397284 0.7000364364391081 21.675425057816962 -6.698214910973967 1.8380328074526973 1.668361841330591 0.7043621857010681 0.4087951010069778 0.4536770859626433 0.3992197742539964 2.6210136807591327 0.19704384427825306 0.5077143247319578 2.0034803581532573e-07 6.698214910973967 -0.9639996556295228 STPVNVPISQK(ub)FTDLFEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STPVNVPISQKFTDLFEK 18 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 20771800.0 3816500.0 5623300.0 11332000.0 True False 5789909.523523709 4619778.1799565675 9092225.233007954 1.0 0.7979016185290914 1.5703570489430505 22.46510937332737 -6.8372125121400344 1.2954646887790555 0.892424374302333 1.5943639698083116 0.919520385276086 0.09278940075887927 0.1720833384777122 0.5622180863330949 0.0561917739020056 0.12936115663947917 1.454747058960594e-07 6.8372125121400344 0.7019395955059786 STPVNVPISQK(ub)FTDLFEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STPVNVPISQKFTDLFEK 18 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 4863300.0 742100.0 2016700.0 2104500.0 True False 1016474.4244984343 1927595.525664918 1607460.4435380127 1.0 1.8963541818733551 1.5814076624025168 19.955142485329777 -10.010524424384949 4.963111917843901 0.9999909281519893 1.7388809221470896 0.8800759862552043 0.12857637819321255 88707390.33187376 3.0400169498929293 9196.542910717739 0.044015114181906206 9.760578881477408e-11 10.010524424384949 0.7388899939951002 STPVNVPISQK(ub)FTDLFEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STPVNVPISQKFTDLFEK 18 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 9581100.0 3459100.0 3243300.0 2878700.0 True False 2876394.9141127127 3225827.6991553544 3480622.8603950595 1.0 1.1214828962908356 1.2100643215984597 21.45583033325124 -6.9745679659567 0.10083546486944776 0.7841273085566345 1.549667796807319 0.9999997316473201 4.423127685134256e-05 0.07484670787638575 0.002961574662646943 0.007906012244456835 0.014432884635246267 1.0603079899451457e-07 6.9745679659567 0.7655404882506844 STPVNVPISQK(ub)FTDLFEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STPVNVPISQKFTDLFEK 18 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 14524600.0 3816500.0 4588800.0 6119300.0 True False 4940534.4844620805 4333429.246120609 5005650.189320256 1.0 0.8771174980660879 1.0131798907715275 22.23623569541982 -13.960059092289802 17.517971161233643 9.005760918346034 0.9506338249769269 0.0 0.06259307710722367 0.0 0.0 0.0 0.018286476305819963 1.0963290139588166e-14 13.960059092289802 -8.055127093369107 STPVSQLGSADFPEAPDPFQPLGADSGDPFQSKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STPVSQLGSADFPEAPDPFQPLGADSGDPFQSKK 34 1 Q9UBC2-2;Q9UBC2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 201713000.0 103070000.0 59102000.0 39541000.0 True False 85707271.77520092 58783605.79517147 47808840.28307259 1.0 0.685864858110911 0.5578154489442738 26.352914278222116 -13.999999999999998 0.1234621554560628 2.4942199812430825 0.3626591667620123 0.9996761364204779 0.0033432062979584704 11.951794310756224 0.10856889702608172 4.36297724268639 0.1732500691426737 1.0000000000000041e-14 13.999999999999998 -2.13156081448107 STPVVHLHFTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STPVVHLHFTR 11 0 Q15542-2;Q15542 Q15542-2 TAF5 Transcription initiation factor TFIID subunit 5 0 14514600.0 3154400.0 4446400.0 6913800.0 False True 4785455.417529983 3652905.180118234 5547284.399573808 1.0 0.7633349099308261 1.1591967567502788 22.190224797556336 -6.744789580237091 1.669222683821718 0.8599715611665406 1.1596770480017282 0.62622059682703 0.09943291377445251 0.30921791783343927 1.6934334085907643 0.04709171712618672 0.11495414503904783 1.7997426961893742e-07 6.744789580237091 0.2997054868351876 STPVVHLHFTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STPVVHLHFTR 11 0 Q15542-2;Q15542 Q15542-2 TAF5 Transcription initiation factor TFIID subunit 5 0 13135900.0 3154400.0 5235800.0 4745700.0 False True 4083432.9825198953 4944423.127361897 3882031.2949940604 1.0 1.2108495838006097 0.9506783413887328 21.961351119648786 -6.691098231672494 1.8623391129460918 1.1320511712331942 0.9515609472216399 0.3756577514319178 0.08915446362422763 0.41430796942591963 2.7867930267827394 0.0382835800001783 0.09956170436136264 2.0365813778118514e-07 6.691098231672494 -0.18049022401155435 STQAATQVVLNVPETR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STQAATQVVLNVPETR 16 0 O75439;G3V0E4;F8WAZ6;F8WEA6;F8WBE1 O75439 PMPCB Mitochondrial-processing peptidase subunit beta 0 13329100.0 4511500.0 4764600.0 4053000.0 False True 5914620.189428141 4053740.2522653346 3633634.4391212626 1.0 0.6853762578890586 0.6143478909459075 22.495854097412213 -13.999999999999996 0.20912141373700738 2.813042461212966 0.5721541638959331 0.9994895363727098 0.0037863032731659347 12.726297897442558 0.14495073449739118 9.476300016080643 0.04233429143911823 1.0000000000000082e-14 13.999999999999996 -2.2408882973170328 STQAATQVVLNVPETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STQAATQVVLNVPETR 16 0 O75439;G3V0E4;F8WAZ6;F8WEA6;F8WBE1 O75439 PMPCB Mitochondrial-processing peptidase subunit beta 0 10577500.0 2196100.0 2157300.0 6224100.0 False True 2126386.007584362 3018721.1401708773 4593821.491002405 1.0 1.4196487041410863 2.1603892588726747 21.0199720856089 -6.962412146093281 0.39998883081839454 0.9592755352688029 2.647809214037641 0.9998494652935935 0.005885981136693975 0.07885044267861288 0.01802818197210873 0.009531128926734491 0.062062176583666084 1.090405049308503e-07 6.962412146093281 1.688533678768838 up STQAATQVVLNVPETR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STQAATQVVLNVPETR 16 0 O75439;G3V0E4;F8WAZ6;F8WEA6;F8WBE1 O75439 PMPCB Mitochondrial-processing peptidase subunit beta 0 36778000.0 5508700.0 21798000.0 9471300.0 False True 8357100.639914854 17907976.591448653 7599293.403581748 1.0 2.1428456306864705 0.9093217529637375 22.994571078864073 -6.663276769451366 1.960998306422884 1.7336299558820827 0.9144026925854248 0.24974016283634448 0.4862168868848288 0.47672097930239193 3.5274025420474553 0.20006771986895508 0.5393020273021786 2.171316989638887e-07 6.663276769451366 -0.8192272632966578 STQAATQVVLNVPETR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STQAATQVVLNVPETR 16 0 O75439;G3V0E4;F8WAZ6;F8WEA6;F8WBE1 O75439 PMPCB Mitochondrial-processing peptidase subunit beta 0 13975000.0 4511500.0 4855300.0 4608200.0 False True 6179523.468703253 4640776.791669995 3519838.068858096 1.0 0.7509926639446588 0.5695970064171824 22.559064158935104 -7.286108793658129 0.1154963345370749 1.372402533699834 2.0918748291261506e-09 0.999998154658993 0.00023960220279857958 0.10644842982105664 0.006387090447775677 0.027303004039473118 0.046155683835638055 5.17477184233759e-08 7.286108793658129 -1.372402531607959 STQAATQVVLNVPETR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STQAATQVVLNVPETR 16 0 O75439;G3V0E4;F8WAZ6;F8WEA6;F8WBE1 O75439 PMPCB Mitochondrial-processing peptidase subunit beta 0 6003200.0 2196100.0 1942600.0 1864500.0 False True 1826154.4537258013 1932134.8282240916 2254358.32952603 1.0 1.0580347266257049 1.2344839314804879 20.800377361043175 -6.951149325550288 0.5460785351007902 0.9975010950559476 1.3032513551665061 0.9992884259087071 0.0026598862629967717 0.08302744153056692 0.034077347849139086 0.00290174695336499 0.014627455309987663 1.1190530479456522e-07 6.951149325550288 0.3057502601105585 STQAPLIIRPDSGNPLDTVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STQAPLIIRPDSGNPLDTVLK 21 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 30705800.0 2647300.0 19198000.0 8860500.0 False True 3470635.936489667 16333733.233217867 7943700.45591757 1.0 4.706265229806393 2.2888313845883044 21.72676860629484 -9.953227710061817 9.341250278199924 1.0000000000000964 3.497548307197351 0.5873177487384345 0.9869132346197674 1.1444867491702467e-08 0.0 0.9555746304585132 0.3185248768195043 1.1137104378234346e-10 9.953227710061817 2.497548307197255 STQAPLIIRPDSGNPLDTVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STQAPLIIRPDSGNPLDTVLK 21 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 29842300.0 8372100.0 7310200.0 14160000.0 False True 8106332.26815584 10229200.982189381 10451071.209105588 1.0 1.2618778312817032 1.2892478205168818 22.95061788013902 -12.555003438672504 0.3423165887999748 1.641319603615299e-07 1.2936453418090055 0.9996581581623947 0.0024106073633208547 7.592981712531736 0.18391299041592127 5.355986666044413 0.008386704907991564 2.786099108666484e-13 12.555003438672504 1.293645177677045 STQAPLIIRPDSGNPLDTVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STQAPLIIRPDSGNPLDTVLK 21 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 32529300.0 2647300.0 15285000.0 14597000.0 False True 3626078.3505925154 14609658.159264274 11149489.23465163 1.0 4.0290519803238665 3.0748064869667697 21.78997866781773 -10.13777467006794 10.146708266116692 0.9999999954490072 3.551929233645318 0.9050852452920904 0.3895690913458803 3.991904084315461e-08 2.215771962829642e-09 0.3771986479345846 0.12573288358164583 7.281575047624774e-11 10.13777467006794 2.551929238196311 STQAPLIIRPDSGNPLDTVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STQAPLIIRPDSGNPLDTVLK 21 1 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 13358000.0 8372100.0 2051900.0 2934000.0 False True 6961772.096916255 2040846.0074297404 3547485.834716746 1.0 0.29315036157729746 0.5095664990653916 22.731023155573297 -10.086576676893594 5.175298131383985 1.0000102597200784 0.4013584303215221 0.9107317007848517 0.08835151816392572 1.1436365722428518e-05 2.0184738447859083e-06 0.08554759166767757 0.028515329870932294 8.192629653786426e-11 10.086576676893594 -0.5986518293985563 STQFEYAWCLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STQFEYAWCLVR 12 0 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 0 4406900.0 1250400.0 1857200.0 1299300.0 False True 1639286.5088908246 1580112.9993088995 1164860.8997656673 1.0 0.9639028874690349 0.7105901826483257 20.64463659510526 -6.932617646191215 0.7249816983768191 1.0035028637848389 0.654940820952979 0.9970281830357227 0.007019647849730858 0.09130127625647731 0.07118695457677696 0.006497871576455757 0.022599582959524266 1.1678373311263556e-07 6.932617646191215 -0.3485620428318599 STQFEYAWCLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STQFEYAWCLVR 12 0 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 0 21126100.0 5216200.0 8879500.0 7030400.0 False True 7913356.755300502 7294883.849149838 5640838.358466209 1.0 0.9218444302114396 0.7128249784376116 22.915858368567825 -6.954000919610601 0.5130440743653754 1.0037525523903528 0.6216991353977479 0.9994790058794077 0.0027670679714562204 0.08191785477666173 0.029613079109350873 0.003170626944631617 0.01725462728695235 1.1117293732125396e-07 6.954000919610601 -0.38205341699260487 STQFEYAWCLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STQFEYAWCLVR 12 0 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 0 4345000.0 1250400.0 1223400.0 1871200.0 False True 1712706.670789439 1169346.1427572065 1429261.0985736875 1.0 0.6827474679118398 0.834504310019939 20.707846656628153 -10.133923624835559 4.7694467060266055 1.0000161214120884 0.7586258889665902 0.7713269598188011 0.06195447137154274 86541031.22206636 0.6048340073041033 16978.13406761744 0.02120866344052273 7.346430513561935e-11 10.133923624835559 -0.24139023244549818 STQFEYAWCLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STQFEYAWCLVR 12 0 Q9Y3D6 Q9Y3D6 FIS1 Mitochondrial fission 1 protein 0 16485900.0 5216200.0 6156400.0 5113300.0 False True 6752473.726673942 5813790.928089461 4182731.8668885804 1.0 0.860986826964398 0.619436970241847 22.686984690660275 -6.962699045563935 0.3955598668481791 1.013946358940932 0.4577204555675919 0.9998575773897381 0.0018764215070689483 0.07875069850250914 0.01766925320181436 0.0031110797953170393 0.02027247597895702 1.0896849542217518e-07 6.962699045563935 -0.5562259033733402 STSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 STSAPSASVGLAPVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQK 53 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 440790000.0 180230000.0 147940000.0 112620000.0 True False 273422086.57793266 121538951.13950421 90360607.63690053 1.0 0.4445103636675757 0.33048027965782245 28.026554545237644 -13.999999999999998 0.22257234530562547 4.390365688584737 0.2709686798281112 0.9995006004139343 0.006535812544654936 13.070862150632202 0.14943487994891905 19.50410830848515 0.06205336077484834 1.0000000000000041e-14 13.999999999999998 -4.119397008756626 STSESFIQHIVSLVHHVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STSESFIQHIVSLVHHVK 18 0 A0A1W2PQ43;E9PK09;E9PQN2;E9PKI6;E9PK91;Q9NYF8-3;Q9NYF8-2;Q9NYF8;Q9NYF8-4;E9PJA7 A0A1W2PQ43 BCLAF1 Bcl-2-associated transcription factor 1 0 45455100.0 11211000.0 19050600.0 15193500.0 False True 14697729.567478437 16208324.738657173 13621422.36634317 1.0 1.1027774503703769 0.9267705126704192 23.80908997609486 -6.748400699647013 1.6556913607455614 1.0605477260261045 0.926460591692489 0.64216026046455 0.04318460120985764 0.30280737119025586 1.6326883864788257 0.02060833611677291 0.05011719218899259 1.7848400411241261e-07 6.748400699647013 -0.13408713433361552 STSESFIQHIVSLVHHVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STSESFIQHIVSLVHHVK 18 0 A0A1W2PQ43;E9PK09;E9PQN2;E9PKI6;E9PK91;Q9NYF8-3;Q9NYF8-2;Q9NYF8;Q9NYF8-4;E9PJA7 A0A1W2PQ43 BCLAF1 Bcl-2-associated transcription factor 1 0 403800500.0 128651100.0 61498000.0 213651400.0 False True 124567141.25055172 86054472.1078334 157689688.93538833 1.0 0.6908280245008213 1.2659011626365786 26.89234831857898 -6.760679474115757 1.6098302074217403 0.8205626836194069 1.268076972344419 0.6937176627546107 0.13005224435594348 0.28180343106837497 1.4395062159086396 0.06373482350533906 0.1530672618883625 1.7350840835201926e-07 6.760679474115757 0.4475142887250121 STSESFIQHIVSLVHHVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STSESFIQHIVSLVHHVK 18 0 A0A1W2PQ43;E9PK09;E9PQN2;E9PKI6;E9PK91;Q9NYF8-3;Q9NYF8-2;Q9NYF8;Q9NYF8-4;E9PJA7 A0A1W2PQ43 BCLAF1 Bcl-2-associated transcription factor 1 0 295966900.0 73145900.0 0.0 222821000.0 False True 110967677.98158346 0.0 178780331.68408638 1.0 0.0 1.6111027547477141 26.725564277059885 -6.738852498517966 1.691185714165029 0.4042167255994265 1.6117609885074689 0.5996916206935053 0.42016709017559395 0.3198803993361574 1.7960056824046737 0.19659347744610353 0.48297803654604143 1.8245152658210415e-07 6.738852498517966 1.2075442629080424 STSESFIQHIVSLVHHVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STSESFIQHIVSLVHHVK 18 0 A0A1W2PQ43;E9PK09;E9PQN2;E9PKI6;E9PK91;Q9NYF8-3;Q9NYF8-2;Q9NYF8;Q9NYF8-4;E9PJA7 A0A1W2PQ43 BCLAF1 Bcl-2-associated transcription factor 1 0 145253000.0 11211000.0 74527100.0 59514900.0 False True 15356009.665883241 71234246.29383737 45458706.36784055 1.0 4.6388513581168125 2.9603202496568546 23.87230003761775 -9.372616013796705 10.362063363697397 1.0000000033567 3.7995858038868353 0.7876448010877372 0.6852574555191977 0.0 9.048394412407795e-18 0.6634976782725778 0.22116589275752582 4.2401770023715903e-10 9.372616013796705 2.799585800530135 STSESFIQHIVSLVHHVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STSESFIQHIVSLVHHVK 18 0 A0A1W2PQ43;E9PK09;E9PQN2;E9PKI6;E9PK91;Q9NYF8-3;Q9NYF8-2;Q9NYF8;Q9NYF8-4;E9PJA7 A0A1W2PQ43 BCLAF1 Bcl-2-associated transcription factor 1 0 407964800.0 128651100.0 155956700.0 123357000.0 False True 106979089.86008085 155116530.3021188 149150378.36167473 1.0 1.4499705550402182 1.3942012271440163 26.672753594013255 -10.530559795749044 6.130327203428949 0.9994407850530085 1.4220858910921168 0.9870758800087831 0.022767732773943155 0.00017423355421002627 1.3342244276265802e-05 0.022072588019963247 0.0073482541553651914 2.947407635436179e-11 10.530559795749044 0.4226451060391083 STSESFIQHIVSLVHHVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STSESFIQHIVSLVHHVK 18 0 A0A1W2PQ43;E9PK09;E9PQN2;E9PKI6;E9PK91;Q9NYF8-3;Q9NYF8-2;Q9NYF8;Q9NYF8-4;E9PJA7 A0A1W2PQ43 BCLAF1 Bcl-2-associated transcription factor 1 0 187005900.0 73145900.0 83169000.0 30691000.0 False True 94688809.47124729 78540572.0385733 25105552.91625316 1.0 0.8294599169337167 0.26513748621875516 26.496690599152334 -6.949229097490826 0.567253245508334 1.0071191933178418 0.06017084151965803 0.9991393198394711 0.009212978155047444 0.08379697886998923 0.03725635476114494 0.009791444136758986 0.04698786910552115 1.1240118827704833e-07 6.949229097490826 -0.9469483517981838 down STSIQSFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STSIQSFK 8 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 4453280.0 504280.0 2202300.0 1746700.0 False True 661115.9634544674 1873725.4244981653 1565968.2395295124 1.0 2.834185722437503 2.368674069443135 19.334543825182116 -10.137548343812574 5.224127208469648 0.9999500035858166 2.6014298959415907 0.9404035005223178 0.19004433653041033 0.00011067106033662254 1.8271131308612497e-05 0.1840153138193915 0.061336545867968474 7.285370723544299e-11 10.137548343812574 1.601479892355774 STSIQSFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STSIQSFK 8 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 5902440.0 1792300.0 918040.0 3192100.0 False True 1735404.4175554174 1284618.1595153562 2355993.2490526806 1.0 0.7402413791967508 1.3576047319111113 20.726840476054406 -6.792451034883484 1.4869827692423763 0.8552812215550474 1.3645783813389796 0.8090245312089834 0.11060242003520311 0.23172303933036845 1.0121963599963844 0.05854367589508678 0.13679730374949353 1.6126828411879283e-07 6.792451034883484 0.5092971597839322 STSIQSFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STSIQSFK 8 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 5165680.0 504280.0 2372200.0 2289200.0 False True 690725.94365459 2267388.360183626 1748538.1075539147 1.0 3.2826164718629336 2.5314498805452463 19.397753886705008 -10.09786858155709 5.536432548790309 0.9999806906125639 2.9070331762046266 0.8957654700661779 0.3066624767609037 7.309073446258487e-05 1.1910993608492424e-05 0.29692765658737974 0.09897488878320053 7.982361987132056e-11 10.09786858155709 1.9070524855920628 STSIQSFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STSIQSFK 8 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 3327860.0 1792300.0 928280.0 607280.0 False True 1490376.8623526953 923279.1713908472 734259.4402545283 1.0 0.6194937634320001 0.49266696149283545 20.507245751488682 -13.999999999999998 0.1535046274079864 2.85054568983773 0.3586020937950382 0.999554966015155 0.004547749270819336 11.972624829925373 0.12356138569845013 6.602755261267872 0.12126968412024089 1.0000000000000041e-14 13.999999999999998 -2.4919435960426917 STSK(ub)EPVDFEQWIEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STSKEPVDFEQWIEK 15 1 A6NIR2;X6R7Y7;Q9Y547 A6NIR2 HSPB11 Intraflagellar transport protein 25 homolog 1 10364700.0 2954500.0 4384200.0 3026000.0 True False 3873378.1114187003 3730094.449477749 2712898.5474416334 1.0 0.9630080880772905 0.7003960030248587 21.885160910567148 -6.932388532946026 0.7269172662618306 1.0036610173976543 0.6430500260329702 0.9969872222832549 0.007320697859561843 0.0914164835287409 0.0717421702017993 0.006766900421664564 0.023457588507557154 1.1684535894538365e-07 6.932388532946026 -0.3606109913646841 STSK(ub)EPVDFEQWIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STSKEPVDFEQWIEK 15 1 A6NIR2;X6R7Y7;Q9Y547 A6NIR2 HSPB11 Intraflagellar transport protein 25 homolog 1 13412600.0 6307600.0 3727300.0 3377700.0 True False 6107368.69060568 5215630.327612715 2492979.0411720313 1.0 0.8539897608663068 0.4081920001009137 22.54211950997823 -6.951054723291893 0.5471407605427647 1.0062723382839636 0.23506889319042024 0.9992814830407091 0.006747540303354769 0.08306494067614344 0.03423066067870434 0.00735082382518827 0.036963195434997966 1.1192968375426096e-07 6.951054723291893 -0.7712034450935433 down STSK(ub)EPVDFEQWIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STSKEPVDFEQWIEK 15 1 A6NIR2;X6R7Y7;Q9Y547 A6NIR2 HSPB11 Intraflagellar transport protein 25 homolog 1 37302700.0 7048700.0 6179000.0 24075000.0 True False 10693393.22899556 5076309.173252644 19316565.697552644 1.0 0.47471453303410094 1.806401886089348 23.350216386106112 -6.799716826943368 1.4572968671201785 0.7100757507095592 1.8246086959107088 0.8312732623421094 0.22496782628992174 0.22116197251889788 0.9273389771749679 0.12145275859591613 0.28247443419888596 1.5859269274393203e-07 6.799716826943368 1.1145329452011496 STSK(ub)EPVDFEQWIEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STSKEPVDFEQWIEK 15 1 A6NIR2;X6R7Y7;Q9Y547 A6NIR2 HSPB11 Intraflagellar transport protein 25 homolog 1 11334400.0 2954500.0 3924700.0 4455200.0 True False 4046858.4923603646 3751293.7767526703 3402973.5177241815 1.0 0.9269644055591122 0.8408926391047018 21.94837097209004 -6.968956383534053 0.28201283458593185 1.0185083310967014 0.7467187302554772 0.9999730459243691 0.00033755824420621396 0.07664293907983198 0.010237452665367951 0.0015716383933330586 0.00788042955830372 1.0740972791848932e-07 6.968956383534053 -0.27178960084122417 STSK(ub)EPVDFEQWIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STSKEPVDFEQWIEK 15 1 A6NIR2;X6R7Y7;Q9Y547 A6NIR2 HSPB11 Intraflagellar transport protein 25 homolog 1 15328100.0 6307600.0 4924300.0 4096200.0 True False 5245048.874058958 4897771.818502979 4952696.481311091 1.0 0.9337895482206949 0.9442612643337247 22.322524785412508 -9.809231931951647 5.507813287359949 1.0000000168508072 0.9390254062779462 0.9783579827680849 0.004275060204066059 1385546.1916253571 2467612.064072597 0.1833279839904281 0.001463466684113234 1.551558189790119e-10 9.809231931951647 -0.06097461057286102 STSK(ub)EPVDFEQWIEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STSKEPVDFEQWIEK 15 1 A6NIR2;X6R7Y7;Q9Y547 A6NIR2 HSPB11 Intraflagellar transport protein 25 homolog 1 49140100.0 7048700.0 8545400.0 33546000.0 True False 9124681.100649249 8069840.9779896885 27440972.21102696 1.0 0.8843970423706637 3.0073349313078404 23.12134270819856 -6.894026135272008 0.9982403765758221 0.8966961671518588 3.2050217826278566 0.9833532977816926 0.12575241344133148 0.11593802930457384 0.20324253661837235 0.09544014363828071 0.2416597519778749 1.2763619967101145e-07 6.894026135272008 2.3083256154759977 up STSLSLFYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STSLSLFYK 9 0 A0A3B3IS71;P06400 A0A3B3IS71 RB1 Retinoblastoma-associated protein 0 5291000.0 1635100.0 2128700.0 1527200.0 False True 1359658.097211902 2117232.2705861335 1846530.4590250237 1.0 1.557179907895745 1.358084405786643 20.374812482954205 -10.109592402005642 4.573650872555897 0.9999612651052107 1.457632156853503 0.8756911480484622 0.0812803984170552 3.210633650753474e-05 6.250702274877284e-06 0.07870605535184305 0.026233135810748126 7.769759890903403e-11 10.109592402005642 0.45767089174829223 STSLTFHWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STSLTFHWK 9 0 A0A087X0R7;Q9H4L4 A0A087X0R7 SENP3-EIF4A1;SENP3 Sentrin-specific protease 3 0 7630500.0 2448700.0 2469900.0 2711900.0 False True 3210269.413244532 2101400.5475947936 2431298.6023816774 1.0 0.6545869760728167 0.7573503308946367 21.614262946061743 -10.396081537000207 8.551108741449877 1.0000020147500939 0.705968653483727 0.9160767286291148 0.04195296392833938 1.611417181229635e-06 1.138604729360331e-07 0.04062106072572608 0.013540260884874904 4.017153833599195e-11 10.396081537000207 -0.2940333612663669 STSYGYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STSYGYSR 8 0 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 0 2178960.0 326650.0 1129500.0 722810.0 False True 428241.31328309927 960983.0027565161 648020.5548831089 1.0 2.2440221738280424 1.513213542885619 18.70806445650674 -10.270992832796704 5.439698366136393 0.999904900934969 1.8786178583568054 0.6583790223293079 0.29835137423863944 0.00034416976620786323 4.6124024027217825e-05 0.28890832652420595 0.09629249197867262 5.358054998896948e-11 10.270992832796704 0.8787129574218364 STSYGYSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STSYGYSR 8 0 Q13242 Q13242 SRSF9 Serine/arginine-rich splicing factor 9 0 2226230.0 326650.0 813180.0 1086400.0 False True 447421.3323843328 777251.0187733417 829814.6951103325 1.0 1.7371791698695465 1.8546605515839052 18.77127451802963 -11.170671475935224 0.3312740905306549 6.713295721276851e-13 1.8789657942906774 0.9993693136726377 0.009499249426594457 3.1773689775242953 0.16897246236774427 2.400047255563119 0.037370527088385945 6.750384705760047e-12 11.170671475935224 1.8789657942900062 STTELPLTVSYDK(ub)VSLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STTELPLTVSYDKVSLGR 18 1 Q96KA5;Q96KA5-2;G5E9Z2 Q96KA5 CLPTM1L Cleft lip and palate transmembrane protein 1-like protein 1 123010000.0 5463700.0 62618100.0 54928200.0 True False 8288832.349974198 51443410.81755161 44071617.19411473 1.0 6.206351949887338 5.316987403449162 22.982737452523057 -9.982624193564499 5.747454112602691 0.9999932325946328 5.761669676670461 0.974503202731554 0.36308155569038203 3.148811470362823e-05 5.570818522286067e-06 0.3515527046141547 0.1171840682075198 1.0408204255475654e-10 9.982624193564499 4.761676444075828 STTELPLTVSYDK(ub)VSLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STTELPLTVSYDKVSLGR 18 1 Q96KA5;Q96KA5-2;G5E9Z2 Q96KA5 CLPTM1L Cleft lip and palate transmembrane protein 1-like protein 1 47785100.0 2267200.0 4196200.0 41321700.0 True False 1885277.253989864 4173594.237719514 49961876.420046 1.0 2.213782736139643 26.501076334693114 20.846345275068924 -6.917285286658758 0.8446208483887993 0.40991042345189077 30.183032389053594 0.9933928895556584 0.9547381213379265 0.09979552314150031 0.11408723096203532 0.810991380990333 2.369671256543855 1.2098031566386477e-07 6.917285286658758 29.773121965601703 up STTELPLTVSYDK(ub)VSLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STTELPLTVSYDKVSLGR 18 1 Q96KA5;Q96KA5-2;G5E9Z2 Q96KA5 CLPTM1L Cleft lip and palate transmembrane protein 1-like protein 1 103254300.0 5463700.0 49216100.0 48574500.0 True False 7072867.355628325 46477180.770571046 39734439.416458845 1.0 6.571193609842864 5.6178685982057415 22.753863774615507 -9.993905703633132 6.020022824121988 0.9999955299337486 6.094531104024883 0.9744096412372899 0.3891933062593616 2.335585507593313e-05 3.902702324689711e-06 0.37683513382746214 0.12561159946619022 1.0141315555620331e-10 9.993905703633132 5.094535574091134 STTFEK(ub)SLLMGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STTFEKSLLMGK 12 1 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07;Q13098-6 Q13098-7 GPS1 COP9 signalosome complex subunit 1 1 6215600.0 1480400.0 2406200.0 2329000.0 True False 1940818.7362139912 2047204.3392941374 2088017.4213455264 1.0 1.054814806295448 1.075843602694541 20.888233952405816 -13.999999991657429 0.13270692869276993 0.7393388615383301 1.1043050721014114 0.9996335062798336 0.0006120204950219276 11.933691045071537 0.11354618457497878 0.8095139795228211 0.02534030356608147 1.00000001920948e-14 13.999999991657429 0.3649662105630813 STTFEK(ub)SLLMGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STTFEKSLLMGK 12 1 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07;Q13098-6 Q13098-7 GPS1 COP9 signalosome complex subunit 1 1 10942100.0 2655500.0 3823400.0 4463200.0 True False 2571202.6060472107 5350103.5587676065 3294154.026870057 1.0 2.0807786777225177 1.2811724829161797 21.294011865696817 -10.065782836725424 4.470412943954987 0.9999574909581761 1.6809755800559536 0.49162484941190177 0.3264378622400639 75486382.13691708 3.485073392192658 35255.49227741362 0.11174836295815516 8.594431673903342e-11 10.065782836725424 0.6810180890977775 STTFEK(ub)SLLMGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STTFEKSLLMGK 12 1 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07;Q13098-6 Q13098-7 GPS1 COP9 signalosome complex subunit 1 1 7650800.0 1480400.0 2208600.0 3961800.0 True False 2027743.8863057287 2111016.7491364805 3026104.435832212 1.0 1.04106675571463 1.49235041775683 20.951444013928707 -6.924700847977904 0.789055815901902 0.9916268779553596 1.5736272233117623 0.9953908609185934 0.015142847904132452 0.09548338683620573 0.09184774020141802 0.013383431472171378 0.04208530643052305 1.1893211771142219e-07 6.924700847977904 0.5820003453564027 STTFEK(ub)SLLMGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STTFEKSLLMGK 12 1 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07;Q13098-6 Q13098-7 GPS1 COP9 signalosome complex subunit 1 1 8484600.0 2655500.0 3820800.0 2008300.0 True False 2208165.9085965445 3800216.592030583 2428226.244669956 1.0 1.7209832726952596 1.0996575190372704 21.074417141131093 -10.333520334537805 5.805122580100434 0.999944522845916 1.410320395866249 0.36768703828581495 0.25365517675205024 0.00018215573129711776 2.0912650737557358e-05 0.24563363778948688 0.08186685626999834 4.639590659804802e-11 10.333520334537805 0.41037587302033296 STTK(ub)VGNIEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STTKVGNIEIK 11 1 P61160;P61160-2;A0A1B0GWD0;A0A1B0GWH0 P61160 ACTR2 Actin-related protein 2 1 42685000.0 22688000.0 19997000.0 0.0 True False 29744187.7109045 17013525.547695473 0.0 1.0 0.5719949629506323 0.0 24.826104444232474 -7.7232351338852325 0.6407314533429089 1.0011878942071535 4.115853724189174e-19 0.9876001466894786 0.04561715486422103 0.11950814622749092 0.15218793231515418 0.042914495299394 0.07790827662291218 1.8913193512528463e-08 7.7232351338852325 -1.0011878942071535 down STTK(ub)VGNIEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STTKVGNIEIK 11 1 P61160;P61160-2;A0A1B0GWD0;A0A1B0GWH0 P61160 ACTR2 Actin-related protein 2 1 51212000.0 26544000.0 14296000.0 10372000.0 True False 25701375.24945098 20004467.35265513 7655262.046669718 1.0 0.7783422933013071 0.29785417987830226 24.615342222559853 -6.958439929325054 0.4568899407876715 1.0144488849562292 0.042478889243045416 0.999707889121178 0.005008928122003123 0.08026318772878863 0.023226566981072786 0.006491794010979689 0.039707375052823055 1.1004240430471024e-07 6.958439929325054 -0.9719699957131838 down STTK(ub)VGNIEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STTKVGNIEIK 11 1 P61160;P61160-2;A0A1B0GWD0;A0A1B0GWH0 P61160 ACTR2 Actin-related protein 2 1 141251000.0 44261000.0 11606000.0 85384000.0 True False 67147172.91253327 9534818.62190812 68507814.9748634 1.0 0.14199880960481082 1.0202635792887738 26.000823323567484 -9.779067555876152 13.672907178236782 1.0000844276474492 0.5811311944474084 0.23270519240107712 0.35855009411147365 0.0 0.0 0.3471646343215758 0.11572154477385857 1.6631539214106214e-10 9.779067555876152 -0.41895323320004085 STTK(ub)VGNIEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STTKVGNIEIK 11 1 P61160;P61160-2;A0A1B0GWD0;A0A1B0GWH0 P61160 ACTR2 Actin-related protein 2 1 39695400.0 22688000.0 14275000.0 2732400.0 True False 31076366.720146157 13644283.298887637 2087063.3955444323 1.0 0.43905658025467736 0.06715918287163965 24.889314505755365 -8.287467796451923 0.42600707308264374 1.0681061404421273 2.878346968747329e-23 0.9962508933185625 0.02347731089533955 0.12341532705863659 0.11946770350495249 0.06833489928012973 0.07928211517443512 5.158604154311648e-09 8.287467796451923 -1.0681061404421273 STTK(ub)VGNIEIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STTKVGNIEIK 11 1 P61160;P61160-2;A0A1B0GWD0;A0A1B0GWH0 P61160 ACTR2 Actin-related protein 2 1 68436700.0 26544000.0 37502000.0 4390700.0 True False 22072512.098582797 37299969.28243586 5308775.0696969405 1.0 1.689883286317499 0.24051521847564417 24.39574749799413 -6.777259924816876 1.5463801194113878 1.3920247578320313 0.22997467951879633 0.7576075316302786 0.2914267961107663 0.2548682911701392 1.2035807594937546 0.14845695768710512 0.35113119531508086 1.6700907674682148e-07 6.777259924816876 -1.162050078313235 STTK(ub)VGNIEIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STTKVGNIEIK 11 1 P61160;P61160-2;A0A1B0GWD0;A0A1B0GWH0 P61160 ACTR2 Actin-related protein 2 1 109899000.0 44261000.0 17191000.0 48447000.0 True False 57296737.014745556 16234305.737896493 39630143.10819845 1.0 0.28333735189350356 0.6916649214771072 25.771949645659934 -10.718290664174756 6.526409227207811 1.0074326297231952 0.48750113668703793 0.6774635548404795 0.16669903223177027 0.018064055431315194 0.0007797257048919658 0.16172690241386534 0.05380188130521163 1.912975182372653e-11 10.718290664174756 -0.5199314930361574 STTLDAGNIK(ub)LAFNSLLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STTLDAGNIKLAFNSLLEK 19 1 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 7333500.0 2122000.0 2571800.0 2639700.0 True False 2054638.271524073 3598733.151759827 1948283.3806974564 1.0 1.751516654603337 0.9482366836534561 20.970452992518755 -6.661189740996856 1.9686536424172867 1.4832828310773434 0.9515879052992877 0.24056793858577474 0.31989147161060044 0.48170872067293025 3.5901002761199985 0.13122254851585477 0.35466517235956074 2.181776496800794e-07 6.661189740996856 -0.5316949257780557 STTLDAGNIK(ub)LAFNSLLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STTLDAGNIKLAFNSLLEK 19 1 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 22235200.0 4626000.0 7922200.0 9687000.0 True False 7017980.205900871 6508421.513568886 7772360.204037077 1.0 0.9273924010353382 1.1074924659237293 22.742624447972073 -6.7972640035041 1.466937334467712 0.9597990398041221 1.109817212508178 0.8240759240918565 0.03103128224072524 0.22468676093757006 0.9547975227081308 0.016643468429122572 0.03877492558330615 1.594909322214842e-07 6.7972640035041 0.15001817270405593 STTLDAGNIK(ub)LAFNSLLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STTLDAGNIKLAFNSLLEK 19 1 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 6765000.0 2122000.0 2257300.0 2385700.0 True False 1764537.0205392065 2245139.4768610327 2884538.839769508 1.0 1.272367454311026 1.634728433687411 20.75085826795303 -6.967174235916001 0.31853729825474053 0.9495152193029622 1.9692433242191962 0.999951203626072 0.0018161600239434495 0.07723069951027896 0.012297946763195568 0.005525609662846734 0.03191564701405486 1.0785139431526224e-07 6.967174235916001 1.0197281049162341 STTLDAGNIK(ub)LAFNSLLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STTLDAGNIKLAFNSLLEK 19 1 O75400-2;O75400;O75400-3 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 1 26251600.0 4626000.0 4884600.0 16741000.0 True False 5988448.192092646 4612767.716091513 13694309.777165746 1.0 0.7702776358961193 2.2867877182686804 22.513750770064522 -6.868300577380259 1.1431158545049938 0.8713335246930227 2.3727544506073746 0.9629538767307592 0.12845042264532833 0.13849109101092436 0.3392996791707626 0.08729733540235424 0.20608178717806447 1.3542518034887905e-07 6.868300577380259 1.5014209259143518 up STTPDITGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STTPDITGYR 10 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 6730700.0 2615400.0 1402900.0 2712400.0 False True 2532375.5585975777 1963085.2860268543 2001941.0697442095 1.0 0.7751951638302832 0.7905387741354125 21.27205994579178 -10.095981489693333 5.01431346798068 1.0000063634656378 0.7828669689820589 0.9962688602254436 0.006264002679352768 4.4562306894931e-07 8.035477956524278e-08 0.006065272164901285 0.0020216981710854502 8.017122328824839e-11 10.095981489693333 -0.21713939448357888 STTTGHLIYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STTTGHLIYK 10 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 1972540000.0 678540000.0 520670000.0 773330000.0 False True 889572510.9907076 442988065.55576414 693313229.9051676 1.0 0.4979785909328661 0.7793779836261261 29.72853696659588 -10.151033112735007 5.477282904996976 1.0000080883929443 0.6386782872794287 0.6873307214023769 0.11488082100483644 1.1347097392668522e-05 1.758867611728025e-06 0.1112353650543711 0.03707762554582857 7.062637032116809e-11 10.151033112735007 -0.36132980111351565 STTTGHLIYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STTTGHLIYK 10 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 1477747000.0 259720000.0 255637000.0 962390000.0 False True 251475330.76354048 357714187.22934383 710311187.918865 1.0 1.4224623391218385 2.8245760161133373 27.90584164051853 -6.9491601046877465 0.5679883030917505 0.9823724444543304 3.3326006988415244 0.9991337228234349 0.022952961614241728 0.0838247414161597 0.03737153747906336 0.02437342415511263 0.11676665840797405 1.1241904595054184e-07 6.9491601046877465 2.350228254387194 up STTTGHLIYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STTTGHLIYK 10 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 2251708400.0 446000000.0 1470800000.0 334908400.0 False True 676614606.9675303 1208324248.587149 268713607.944434 1.0 1.7858382543685383 0.39714426082044246 29.333759081918277 -6.753122733709454 1.6378217924643834 1.4603114218471844 0.39362556274158306 0.6625590664939537 0.3302804844155769 0.2945907335974476 1.5555997498742455 0.15922545177795197 0.38536839845052 1.7655388004198392e-07 6.753122733709454 -1.0666858591056014 STTTGHLIYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STTTGHLIYK 10 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 1740572500.0 678540000.0 428192500.0 633840000.0 False True 929414574.8540201 409273539.50675625 484140046.3445631 1.0 0.44035627434725716 0.520908601439358 29.79174702811877 -10.693067053706681 6.777238403112221 1.0043183423374322 0.48063243789350807 0.9822784208156617 0.0328853498282361 0.0021537737387232075 9.754171982118656e-05 0.03196053378009792 0.010613701018246935 2.027369675832398e-11 10.693067053706681 -0.5236859044439242 STTTGHLIYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STTTGHLIYK 10 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 699850000.0 259720000.0 276270000.0 163860000.0 False True 215968687.546863 274781678.67469835 198122368.39696202 1.0 1.2723218434851744 0.9173661730660445 27.686246915952808 -6.7017161113337815 1.8245733029605096 1.168813956237798 0.9183811811377168 0.42580169055934414 0.11491454639908089 0.3919662368363277 2.5380120164329347 0.05022090148775514 0.12889045197585022 1.987393607951567e-07 6.7017161113337815 -0.2504327751000811 STTTGHLIYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STTTGHLIYK 10 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 1092045400.0 446000000.0 315750000.0 330295400.0 False True 577355791.9743462 298178234.9334427 270185026.3169988 1.0 0.5164549123405897 0.4679697165469919 29.104885404010727 -13.999999999999998 0.3250876270960741 6.110710844381933 0.45888117577892173 0.999704555853 0.004128506099074413 18.416914654239058 0.1820727029593587 64.1896420589769 0.015828203845831883 1.0000000000000041e-14 13.999999999999998 -5.651829668603011 STTTGHLIYK(ub)CGGIDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STTTGHLIYKCGGIDK 16 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 56247400.0 18511900.0 17538000.0 20197500.0 True False 24269280.169494588 14921398.762588566 18107656.448100585 1.0 0.6148265897619867 0.746114277870553 24.532627982782937 -10.377346429840738 5.057951250943896 1.0002265476938823 0.6804704338162343 0.8876142067919355 0.053597974229398396 0.0001370215872174626 1.68679874833534e-05 0.05193244392380028 0.017298671798391847 4.194242823979364e-11 10.377346429840738 -0.319756113877648 STTTGHLIYK(ub)CGGIDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STTTGHLIYKCGGIDK 16 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 26555800.0 11656400.0 12526400.0 2373000.0 True False 11286373.962390786 17528256.84431302 1751440.1115259589 1.0 1.5530459032034432 0.15518182521350304 23.428078721914453 -6.799356398332744 1.4585005574027439 1.3053847077414154 0.13617812610336028 0.8303008406879364 0.23678815530526504 0.22166738490596571 0.9309885262202187 0.1277241303911277 0.29716153412356083 1.5872436623380567e-07 6.799356398332744 -1.169206581638055 down STTTGHLIYK(ub)CGGIDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STTTGHLIYKCGGIDK 16 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 53524300.0 18511900.0 15648800.0 19363600.0 True False 25356249.6952871 14957384.272338547 14790316.485860135 1.0 0.5898894533728557 0.5833006325304161 24.59583804430583 STTTGHLIYK(ub)CGGIDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STTTGHLIYKCGGIDK 16 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 36838800.0 11656400.0 14511100.0 10671300.0 True False 9692813.066075986 14432925.824072165 12902619.491483577 1.0 1.4890337537392697 1.3311532373033828 23.20848399734873 -9.96497197865709 4.684249641336175 0.9999948123050041 1.4100934953997086 0.8999595631919516 0.06445445103808707 22133025.69122804 0.9176888112578968 1388.2280675016177 0.022064472962376062 1.083996852896536e-10 9.96497197865709 0.41009868309470454 STTTGHLIYK(ub)CGGIDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STTTGHLIYKCGGIDK 16 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 31174300.0 20281800.0 8402000.0 2490500.0 True False 26255189.91404773 7934421.3140484085 2037254.5546879692 1.0 0.30220392006393865 0.07759435606283482 24.646099295492387 -9.941674932450253 0.29363838128167585 1.4883970027486857 3.6691796605852317e-16 0.9988132727362596 0.013529456224191829 1.3836917435879443 0.13379662782051976 0.6551383505596389 0.08126092504203664 1.1437340945287161e-10 9.941674932450253 -1.4883970027486852 STTTGHLIYK(ub)CGGIDK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 STTTGHLIYKCGGIDKR 17 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 2 4661100.0 1748100.0 1320000.0 1593000.0 True False 2291776.028624479 1123061.145319699 1428171.6411350043 1.0 0.490039659762808 0.6231724319030385 21.128034628174074 -10.270835784530691 8.370072190722189 1.0000003496492875 0.5566060458329601 0.9366660651828547 0.05435122663096412 3.545701846331926e-07 3.0917225968452904e-08 0.05262539045600738 0.017541782965639092 5.359992913021361e-11 10.270835784530691 -0.4433943038163274 STTTGHLIYK(ub)CGGIDK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STTTGHLIYKCGGIDKR 17 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 2 5505100.0 1748100.0 1818900.0 1938100.0 True False 2394419.810626213 1738534.9837020463 1480360.6964224377 1.0 0.726077764637007 0.6182544472162878 21.191244689696966 -13.999999999999996 0.12881299876108837 2.3016131160429394 0.4649540768655056 0.9996510218487789 0.003001820888527196 11.938737479529456 0.11149227645828272 3.9387096077780086 0.1362778081581628 1.0000000000000082e-14 13.999999999999996 -1.8366590391774338 STTTGHLIYK(ub)CGGIDK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STTTGHLIYKCGGIDKR 17 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 2 5121800.0 1145400.0 2176700.0 1799700.0 True False 952450.8498235658 2164973.6850588787 2176008.94912738 1.0 2.27305554450387 2.2846417214394514 19.861285120275998 -10.866079193467723 0.805915947992493 2.5427562040907763e-13 2.282133946178418 0.99998905554284 0.001994442624550587 2.7654600456968095 0.43112213967763946 5.2655572247206175 0.001665918625586837 1.3611964460725342e-11 10.866079193467723 2.2821339461781633 STTTGHLIYK(ub)CGGIDK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STTTGHLIYKCGGIDKR 17 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 2 11957800.0 4179400.0 2863400.0 4915000.0 True False 5410315.688290537 2704049.27286911 4020520.4321587533 1.0 0.49979510044514447 0.7431212268926014 22.36728134612 -10.090292579932962 5.188413572771377 1.0000072139894665 0.6214581636682415 0.763421461051982 0.09933747514957478 8.289713126324102e-06 1.4533463865503747e-06 0.09618492912718257 0.032061032242065544 8.122831046310758e-11 10.090292579932962 -0.378549050321225 STTTGHLIYK(ub)CGGIDKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STTTGHLIYKCGGIDKR 17 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 32400800.0 6915800.0 14704000.0 10781000.0 True False 9066680.772702478 12510220.515743092 9665485.538654417 1.0 1.3798015866410844 1.066044540550583 23.11214305952762 -10.218781251534317 5.904401703135952 0.9999945609169081 1.2229230635958357 0.4022972258431964 0.12809077768744598 9.171296696592512e-06 1.2132566187417123e-06 0.12402638691119412 0.04134112073218519 6.04252907047124e-11 10.218781251534317 0.2229285026789276 STTTGHLIYK(ub)CGGIDKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STTTGHLIYKCGGIDKR 17 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 27199700.0 11388000.0 9960000.0 5851700.0 True False 11026494.173476046 13937079.940713858 4318964.222762935 1.0 1.2639629352218906 0.39168970253048285 23.394470829346258 -6.82552142271966 1.3477017925434103 1.1415354956721924 0.3702754942910162 0.8966494095877927 0.11741686917963494 0.18639279960455649 0.6636424794513823 0.0684345018510273 0.15755643124137908 1.4944403233415691e-07 6.82552142271966 -0.7712600013811761 down STTTGHLIYK(ub)CGGIDKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STTTGHLIYKCGGIDKR 17 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 89752000.0 39908000.0 16268000.0 33576000.0 True False 60543353.66560579 13364848.297535857 26939688.88311639 1.0 0.22074839744347238 0.4449652563336712 25.851465256501704 -10.336027269860383 6.341594567667737 1.0000410745214823 0.33285682689402674 0.9219012463759366 0.09153614933510128 5.316091333697572e-05 5.5660431533930325e-06 0.0886349197834714 0.02954316516256679 4.612886087976903e-11 10.336027269860383 -0.6671842476274555 STTTGHLIYK(ub)CGGIDKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STTTGHLIYKCGGIDKR 17 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 35704800.0 6915800.0 13238000.0 15551000.0 True False 9472758.152467705 12653101.387788074 11878174.082898367 1.0 1.3357357154201042 1.2539298366657907 23.175353121050513 -10.092373982829267 4.405671897261168 0.9999717815299338 1.2948327760300207 0.9454116778114718 0.03339711023329287 23229721.919776518 0.5594298458558126 6968.575271135185 0.011432719131654221 8.083994645237074e-11 10.092373982829267 0.29486099450008685 STTTGHLIYK(ub)CGGIDKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STTTGHLIYKCGGIDKR 17 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 32481800.0 11388000.0 12349000.0 8744800.0 True False 9469626.57393992 12282473.48591541 10573297.248613164 1.0 1.2970388420295629 1.116548489642718 23.174876104780534 -10.218635107997143 3.864917846494843 0.9998045532151932 1.2067936658992053 0.6363994200559537 0.07368487804183806 23229350.394636434 26432238.960553743 48894.51952832008 0.026965904925326 6.044562771580607e-11 10.218635107997143 0.2069891126840121 STTTGHLIYK(ub)CGGIDKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STTTGHLIYKCGGIDKR 17 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 83535000.0 39908000.0 20460000.0 23167000.0 True False 51661692.70428743 19321383.01421454 18950843.71349375 1.0 0.3739982567898138 0.36682583789828105 25.622591578594154 STTTIGLVQALGAHLYQNVFACVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STTTIGLVQALGAHLYQNVFACVR 24 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 10928819200.0 4471100100.0 3064766000.0 3392953100.0 False True 6782985732.901315 2517834562.1739507 2722334432.60083 1.0 0.3711985637771623 0.4013475097545863 32.65927331228497 -10.73311974892838 6.862655839521945 1.0090462355174685 0.3862730367658743 0.9981933671689094 0.01230825565457069 0.001694026563734691 6.587850540371189e-05 0.011850696780002964 0.0039724724309179605 1.8487587865549455e-11 10.73311974892838 -0.6227731987515942 STTTIGLVQALGAHLYQNVFACVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STTTIGLVQALGAHLYQNVFACVR 24 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 10356700100.0 4471100100.0 3653200000.0 2232400000.0 False True 5787927218.009118 3449896208.5791078 1826126106.3583322 1.0 0.5960503784229985 0.3155060590043956 32.43039963437741 -8.13360098225787 0.2142090776351478 1.2426306969662986 2.7405574318941512e-11 0.9997471169091421 0.004467798056643702 0.0889170986609725 0.042501673877355636 0.09122444324300154 0.10765975323665049 7.35189029268892e-09 8.13360098225787 -1.242630696938893 down STVALTAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STVALTAAR 9 0 A0A087WV29;Q9H0A0-2;Q9H0A0 A0A087WV29 NAT10 N-acetyltransferase 10 0 2828720.0 1040100.0 750220.0 1038400.0 False True 1363581.1723427281 638290.1003346563 930956.3290361499 1.0 0.4680983525447401 0.6827289404683563 20.378969154029587 -10.226178362525191 5.508929038550596 1.0000231759498364 0.5754136465065226 0.8391714542815761 0.08762257060116457 2.4942823386574826e-05 3.5037022727420976e-06 0.08484481268270055 0.028280063057502483 5.940481359747352e-11 10.226178362525191 -0.42460952944331376 STVALTAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STVALTAAR 9 0 A0A087WV29;Q9H0A0-2;Q9H0A0 A0A087WV29 NAT10 N-acetyltransferase 10 0 2113410.0 1040100.0 408380.0 664930.0 False True 1424653.0776456303 390336.421267932 507887.2286632118 1.0 0.2739869989352065 0.3564988814698256 20.44217921555248 -10.590281443216615 6.482529462677806 1.0015119029092583 0.31524294021757615 0.9892274776954793 0.033685334987713325 0.0007373047805441564 4.6600140455540774e-05 0.032671002037417504 0.01087189511823597 2.5687305852298103e-11 10.590281443216615 -0.6862689626916821 STVAQLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STVAQLVK 8 0 P25705;P25705-2;P25705-3;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 20677600.0 2711000.0 10164000.0 7802600.0 False True 3554147.2533613453 8647570.81896169 6995261.799824224 1.0 2.4330930044564765 1.9681969544757703 21.76107202483067 -10.360565696556284 6.125856916668061 0.9998546796340944 2.200644979466113 0.8989200904545578 0.18979301764802756 0.0003767307114252142 3.9324051904823726e-05 0.18378776207047842 0.061255433048104865 4.3594761238372e-11 10.360565696556284 1.2007902998320188 STVAQLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STVAQLVK 8 0 P25705;P25705-2;P25705-3;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 25130800.0 7742800.0 3515000.0 13873000.0 False True 7497009.052194449 4918557.830482848 10239245.118921028 1.0 0.6560693466207217 1.3657773450231996 22.837883713439822 -6.774920353028112 1.5554844833794395 0.8039721543865843 1.3705458623291156 0.7490564117990717 0.14516459366270568 0.25855366368770066 1.2351870014949082 0.07353002155085377 0.1742638289282967 1.679111928823044e-07 6.774920353028112 0.5665737079425313 STVAQLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STVAQLVK 8 0 P25705;P25705-2;P25705-3;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 69247300.0 5603800.0 58255000.0 5388500.0 False True 8501374.292656139 47858940.10160756 4323460.613136546 1.0 5.629553346798319 0.508560200304478 23.019264648802192 -6.6686401084052465 1.9427366279580343 3.9585078616160816 0.5296014045346452 0.27289875361166016 1.967155649241899 0.4641875594588234 3.3764409660653527 0.8156628212975233 2.1826867918889032 2.1446671098695373e-07 6.6686401084052465 -3.4289064570814363 STVAQLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STVAQLVK 8 0 P25705;P25705-2;P25705-3;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 22858100.0 2711000.0 9639100.0 10508000.0 False True 3713329.9620202896 9213212.68975888 8026226.819053185 1.0 2.4811187758672277 2.1614634037763785 21.824282086353563 -10.520055657938737 5.155302512857416 0.9955665664788484 2.321291089821812 0.9579495261910103 0.13049875919373435 0.006653436078408275 0.0006194158514679982 0.1264257415295084 0.04211829342149749 3.019564716825625e-11 10.520055657938737 1.3257245233429638 STVAQLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STVAQLVK 8 0 P25705;P25705-2;P25705-3;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 17220800.0 5603800.0 5599600.0 6017400.0 False True 7254229.567412185 5287977.337556001 4922294.943737963 1.0 0.7289509228258945 0.6785413803073099 22.79039097089464 -13.999999999999998 0.2365527936818595 2.7645861477484326 0.6555115295692446 0.9995194079728236 0.0030946400564474926 13.504155784310937 0.1539540914540445 11.233997481377427 0.02514088649346178 1.0000000000000041e-14 13.999999999999998 -2.109074618179188 STVAQLVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 STVAQLVKR 9 1 P25705;P25705-2;P25705-3;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 1 5924500.0 580640.0 1586560.0 3757300.0 True False 562207.901026267 2220081.6818011003 2773150.4134161314 1.0 3.9488624719583503 4.93260661821714 19.1007442033086 -9.30874894847367 0.360409231942545 8.785776684833208e-21 5.162726932775765 0.9982253969017509 0.07039088449338528 0.6921280447655571 0.1405109783068589 1.2082178950046887 0.27717900408291196 4.911917360795262e-10 9.30874894847367 5.162726932775765 STVAQLVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 STVAQLVKR 9 1 P25705;P25705-2;P25705-3;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 1 14834050.0 1625960.0 915490.0 12292600.0 True False 2466700.1935984856 752113.6567439832 9862962.22196203 1.0 0.3049067976302302 3.998443851246343 21.234150948321453 -6.858025670186859 1.1955965794208208 0.6246479143693785 4.170736802259236 0.9512003458389096 0.35403304378075434 0.1488534939641887 0.40543698354787655 0.23112429466242387 0.5383966433108235 1.3866738632225615e-07 6.858025670186859 3.5460888878898573 up STVAQLVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STVAQLVKR 9 1 P25705;P25705-2;P25705-3;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 1 2165850.0 861940.0 491470.0 812440.0 True False 1180622.5110526625 469755.230326046 620558.4047270247 1.0 0.3978877464459021 0.525619661591684 20.17111632450149 -9.835161668949734 6.565284695667155 1.0000000121195298 0.4617537040194032 0.9594742249783405 0.05214633599613728 9.217966212856504e-09 1.6616670586870882e-09 0.050490473848155235 0.01683015757320232 1.4616329707773717e-10 9.835161668949734 -0.5382463081001266 STVAQLVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STVAQLVKR 9 1 P25705;P25705-2;P25705-3;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 1 5645040.0 580640.0 2548600.0 2515800.0 True False 482827.88671342394 2534870.185942505 3041842.148255073 1.0 5.250049252948481 6.300054806197468 18.881149478742877 -9.38288789386332 0.4438554360305064 1.8701713544514332e-22 6.373635152937731 0.9980574486933991 0.10099352351311562 0.7364120841306515 0.18206264654218896 1.5100228624943688 0.23749226496735792 4.1410655597255185e-10 9.38288789386332 6.373635152937731 STVAQLVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STVAQLVKR 9 1 P25705;P25705-2;P25705-3;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 1 9837760.0 1625960.0 2106900.0 6104900.0 True False 2104837.2724632444 1989649.1628860517 4993870.8415637845 1.0 0.9452745772396977 2.3725686098857266 21.005277270413902 -6.897984383274721 0.9739351039867694 0.9373320534396856 2.5163962727498266 0.9855361753690391 0.0794128491890256 0.11290374830383865 0.18591105746051734 0.061379200947243036 0.15814076298300433 1.2647818267393157e-07 6.897984383274721 1.579064219310141 up STVCGPESFTPDHK(ub)PLMGEAPELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STVCGPESFTPDHKPLMGEAPELR 24 1 Q9UL12;Q9UL12-2;A0A0A0MT55;Q5SYV1 Q9UL12 SARDH Sarcosine dehydrogenase, mitochondrial 1 13664300.0 3699300.0 4250400.0 5714600.0 True False 4849818.1240721615 3616256.887929436 5123308.010313928 1.0 0.745647938833021 1.0563917819689557 22.209499214269478 -6.689154852411461 1.8694866236954921 0.840409176426134 1.0553045003940302 0.36641809970196704 0.10759189466944713 0.4185011298995088 2.835182990776833 0.04605250656938102 0.12004884406512578 2.045715084749408e-07 6.689154852411461 0.21489532396789623 STVCGPESFTPDHK(ub)PLMGEAPELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STVCGPESFTPDHKPLMGEAPELR 24 1 Q9UL12;Q9UL12-2;A0A0A0MT55;Q5SYV1 Q9UL12 SARDH Sarcosine dehydrogenase, mitochondrial 1 16176800.0 3699300.0 5662400.0 6815100.0 True False 5067031.179823557 5412216.4449472055 5205513.741390309 1.0 1.068123769693414 1.0273301182984973 22.27270927579237 -10.209627952797629 4.200449696249655 0.9999771529451185 1.0477269439989636 0.6460271286289597 0.016653938453950332 3.565068383631904e-06 6.70844672848644e-07 0.01613282537053421 0.005375035521998174 6.171234468318945e-11 10.209627952797629 0.047749791053845136 STVCGPESFTPDHK(ub)PLMGEAPELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STVCGPESFTPDHKPLMGEAPELR 24 1 Q9UL12;Q9UL12-2;A0A0A0MT55;Q5SYV1 Q9UL12 SARDH Sarcosine dehydrogenase, mitochondrial 1 31183800.0 11227000.0 9217800.0 10739000.0 True False 14533572.817255542 8704821.32690259 8784612.19144514 1.0 0.5989457263094631 0.6044358329436567 23.792886071388477 -10.100479642420872 5.6281075807029675 1.0000034484414635 0.6016907796267034 0.9998575301041818 0.0022413266481190034 9.698495682261013e-08 1.5499492758919587e-08 0.0021701739792296675 0.00072338506509566 7.934514489882983e-11 10.100479642420872 -0.39831266881476013 STVFGTALNYVSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STVFGTALNYVSLR 14 0 P48449;P48449-3;P48449-2;C9J315 P48449 LSS Lanosterol synthase 0 15856600.0 3193100.0 6764400.0 5899100.0 False True 4186185.0220243875 5755177.887424688 5288717.720162896 1.0 1.374802560600046 1.2633740965432383 21.997204646913502 -10.079436954631028 4.362333051217716 0.9999696632858577 1.3190883285319333 0.916203890700087 0.04549048007147 15800418.166749729 0.23103213954394108 4883.275490125813 0.0155726012878256 8.328428187758147e-11 10.079436954631028 0.3191186652460756 STVFGTALNYVSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STVFGTALNYVSLR 14 0 P48449;P48449-3;P48449-2;C9J315 P48449 LSS Lanosterol synthase 0 15742100.0 7797900.0 2600800.0 5343400.0 False True 7550359.932854658 3639313.002992831 3943803.2414360708 1.0 0.48200523357260283 0.5223331439174169 22.84811399004893 -10.185895125217508 6.00258831040151 1.0000064616741868 0.5021691900829918 0.9951024710115555 0.01646380045626569 1.4237028565006213e-06 1.931204998416762e-07 0.015941213014507533 0.00531366874853102 6.517857703136133e-11 10.185895125217508 -0.49783727159119506 STVFGTALNYVSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STVFGTALNYVSLR 14 0 P48449;P48449-3;P48449-2;C9J315 P48449 LSS Lanosterol synthase 0 17648700.0 3193100.0 5241100.0 9214500.0 False True 4373675.3602829175 5009530.8719999995 7038224.878584466 1.0 1.1453824208104808 1.6092243476729349 22.060414708436394 -6.950058822587579 0.5581957913979958 0.9938753197582899 1.7828307188033012 0.9992059028464622 0.007320942765523481 0.08346209875755939 0.035864435079159755 0.007864843782007287 0.03854290763013556 1.121866493910822e-07 6.950058822587579 0.7889553990450113 STVFGTALNYVSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STVFGTALNYVSLR 14 0 P48449;P48449-3;P48449-2;C9J315 P48449 LSS Lanosterol synthase 0 16063900.0 7797900.0 2859200.0 5406800.0 False True 6484299.35554321 2843796.922093237 6537336.881781364 1.0 0.43856656921031417 1.0081793765725535 22.628519265483206 -10.94456885515913 10.875936400060034 1.0690285899298784 0.7233729728916319 0.2392325991688039 0.23254345483195596 0.12221227030130415 0.000622875805248034 0.0706973167687084 0.0750530773194751 1.1361381545192592e-11 10.94456885515913 -0.34565561703824643 STVFK(ub)TTIPEEEEEEEEAAGVVVEEELFHQQGTPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STVFKTTIPEEEEEEEEAAGVVVEEELFHQQGTPR 35 1 P20700 P20700 LMNB1 Lamin-B1 1 92772000.0 29840000.0 33659000.0 29273000.0 True False 45269461.59621319 27652288.47103265 23487178.719188336 1.0 0.6108375822465221 0.5188305292580075 25.432034812478484 -13.99999999999998 0.20258931409134248 3.1849384586897767 0.460578615535189 0.999487223645795 0.004722513537849754 12.583308527786473 0.1427075613379293 10.906475968682894 0.057474150494111906 1.000000000000045e-14 13.99999999999998 -2.7243598431545877 STVISGPGTGK(ub)GSQDHSGDPTSGDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STVISGPGTGKGSQDHSGDPTSGDR 25 1 Q96JZ2;Q96JZ2-2 Q96JZ2 HSH2D Hematopoietic SH2 domain-containing protein 1 7418050.0 1820500.0 2384300.0 3213250.0 True False 1762709.2239913193 3336363.423960241 2371603.4295662786 1.0 1.8927474699461102 1.3454308840548497 20.749363077048507 -10.373882028706323 5.841344844528004 0.9998637356566398 1.619089177000481 0.6304449029584751 0.2234410605326286 0.0003966006459231882 4.2511111623244515e-05 0.2163927615520049 0.0721152921918157 4.227834431161804e-11 10.373882028706323 0.6192254413438412 STVISGPGTGK(ub)GSQDHSGDPTSGDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 STVISGPGTGKGSQDHSGDPTSGDR 25 1 Q96JZ2;Q96JZ2-2 Q96JZ2 HSH2D Hematopoietic SH2 domain-containing protein 1 12578700.0 3885000.0 5033000.0 3660700.0 True False 5893829.031544511 4134821.8269915176 2937161.040458193 1.0 0.7015510298757281 0.49834513772594 22.490773780630956 -8.08580871912679 0.12791034509460744 1.4236884903486398 1.3151025908246398e-13 0.9999695303060175 0.0011372380846742189 0.0953159754375792 0.023000697211046375 0.11134003089105955 0.12505045527611675 8.20712939944489e-09 8.08580871912679 -1.4236884903485083 down STVISGPGTGK(ub)GSQDHSGDPTSGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STVISGPGTGKGSQDHSGDPTSGDR 25 1 Q96JZ2;Q96JZ2-2 Q96JZ2 HSH2D Hematopoietic SH2 domain-containing protein 1 4935800.0 1704700.0 1511000.0 1720100.0 True False 2334973.6577853137 1444239.0237911902 1313847.806571504 1.0 0.6185247610720493 0.5626820680356919 21.154974843457456 -13.999999999999998 0.2706064823928048 3.9539758571655668 0.5442545339696309 0.9995846329841027 0.003960615425277271 14.9127230507606 0.16467792936289008 24.243213819223914 0.023122393265280438 1.0000000000000041e-14 13.999999999999998 -3.409721323195936 STVISGPGTGK(ub)GSQDHSGDPTSGDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STVISGPGTGKGSQDHSGDPTSGDR 25 1 Q96JZ2;Q96JZ2-2 Q96JZ2 HSH2D Hematopoietic SH2 domain-containing protein 1 21153300.0 3885000.0 5420600.0 11847700.0 True False 5029209.084798952 5118938.844909648 9691540.167667799 1.0 1.0178417239366544 1.9270505569078422 22.261900102723406 -6.911146871483513 0.8878908416199145 0.9728581264953885 2.0474777799577866 0.9913467908132269 0.04026686939869987 0.10366557532384148 0.13469200957832847 0.033154774827030276 0.09226572698404345 1.227024200923066e-07 6.911146871483513 1.0746196534623982 STVLSLDWHPNNVLLAAGSCDFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 STVLSLDWHPNNVLLAAGSCDFK 23 0 A0A1W2PNV4;Q92747;E9PF58;Q92747-2;O15143;C9JEY1;C9K057 A0A1W2PNV4;O15143 ARPC1A;ARPC1B Actin-related protein 2/3 complex subunit 1A;Actin-related protein 2/3 complex subunit 1B 0 147540000.0 50639000.0 46479000.0 50422000.0 False True 76823065.20679085 38184459.30791552 40456069.599252306 1.0 0.49704420417398515 0.5266135826571543 26.195036192131727 -10.745083703097428 6.901257035493359 1.0084982437544219 0.5118288934155697 0.9972558477419851 0.012071648215832741 0.0015771346982011965 5.825559500414563e-05 0.011678718279540867 0.0038961077084328933 1.798524245841861e-11 10.745083703097428 -0.4966693503388522 STVLSLDWHPNNVLLAAGSCDFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STVLSLDWHPNNVLLAAGSCDFK 23 0 A0A1W2PNV4;Q92747;E9PF58;Q92747-2;O15143;C9JEY1;C9K057 A0A1W2PNV4;O15143 ARPC1A;ARPC1B Actin-related protein 2/3 complex subunit 1A;Actin-related protein 2/3 complex subunit 1B 0 100150000.0 50639000.0 20781000.0 28730000.0 False True 65553183.74392124 19624519.082032844 23501434.794694033 1.0 0.2993679019266952 0.35850943390485324 25.966162514224177 -10.380854718776696 5.178242051625089 1.0004175207685861 0.32893866791573734 0.9942083884921754 0.024144429325625532 0.00011644967236661258 1.39234860820125e-05 0.023391700745986194 0.007792581056800636 4.160497651748053e-11 10.380854718776696 -0.6714788528528488 STVQFHILGMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STVQFHILGMK 11 0 Q96PM5-7;Q96PM5-6;Q96PM5;Q96PM5-8;Q96PM5-2 Q96PM5-7 RCHY1 RING finger and CHY zinc finger domain-containing protein 1 0 19872860.0 5604070.0 5117690.0 9151100.0 False True 7346990.039891072 4354150.600599375 8204231.955549601 1.0 0.592644140928212 1.1166793354835198 22.808721888127227 -6.699252070300214 1.833730902395678 0.7468582791923812 1.1150880108537882 0.41392266745995854 0.171974239097465 0.39708976718193884 2.595425686678472 0.07483688753673044 0.19262474476061567 1.9987014599653175e-07 6.699252070300214 0.36822973166140693 STVQFHILGMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STVQFHILGMK 11 0 Q96PM5-7;Q96PM5-6;Q96PM5;Q96PM5-8;Q96PM5-2 Q96PM5-7 RCHY1 RING finger and CHY zinc finger domain-containing protein 1 0 14623740.0 5573500.0 3722140.0 5328100.0 False True 5396572.29327965 5208409.912703677 3932510.770426235 1.0 0.9651329825025616 0.7287052886002083 22.3636119200003 -6.933304405849722 0.7191488438571128 1.0031919488208503 0.675813686130425 0.9971487914846552 0.0064350967810006465 0.09095799050222575 0.06953781603437854 0.00598248328935794 0.02101747718875748 1.1659920629839879e-07 6.933304405849722 -0.32737826269042525 STVQFHILGMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STVQFHILGMK 11 0 Q96PM5-7;Q96PM5-6;Q96PM5;Q96PM5-8;Q96PM5-2 Q96PM5-7 RCHY1 RING finger and CHY zinc finger domain-containing protein 1 0 21095120.0 5604070.0 5099550.0 10391500.0 False True 7676046.123297316 4874235.019043253 7937241.719660369 1.0 0.6349929300515302 1.034027361504552 22.87193194965012 -6.666078642860436 1.951379781408386 0.7662376964926719 1.0323870637299217 0.2617902787985791 0.15518825645494008 0.4701584927368736 3.447690126793524 0.06411262086046576 0.1721669007023477 2.157353716117358e-07 6.666078642860436 0.2661493672372498 STVQFHILGMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STVQFHILGMK 11 0 Q96PM5-7;Q96PM5-6;Q96PM5;Q96PM5-8;Q96PM5-2 Q96PM5-7 RCHY1 RING finger and CHY zinc finger domain-containing protein 1 0 16350000.0 3177800.0 8014000.0 5158200.0 False True 4113724.743802855 7568013.855127821 4219460.527601488 1.0 1.8396986493879302 1.0257031742237785 21.972013833280368 -10.375209879119616 4.424986667723324 0.99925612519919 1.4327009118074676 0.27365954905920165 0.3323122611865497 0.00244275829142081 0.0003449065960068864 0.32229428045682845 0.10725332110890476 4.214927616996807e-11 10.375209879119616 0.43344478660827757 STVTLSWKPVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STVTLSWKPVQK 12 1 G3V1C3;Q9BZZ5-2;Q9BZZ5;Q9BZZ5-6;Q9BZZ5-1;Q9BZZ5-5;H0YER7 G3V1C3 API5 Apoptosis inhibitor 5 0 284165300.0 95101200.0 103501100.0 85563000.0 False True 124678594.1613309 88059139.32412799 76709761.53825124 1.0 0.7062891582670697 0.6152600777563371 26.893638551867223 -13.999999999999998 0.16403422753773766 2.4594982244500856 0.5296410390904297 0.9995263426482144 0.0035730185692404042 12.039036003387999 0.1281145633685396 5.589464391802862 0.07844856463706316 1.0000000000000041e-14 13.999999999999998 -1.9298571853596558 STVTLSWKPVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STVTLSWKPVQK 12 1 G3V1C3;Q9BZZ5-2;Q9BZZ5;Q9BZZ5-6;Q9BZZ5-1;Q9BZZ5-5;H0YER7 G3V1C3 API5 Apoptosis inhibitor 5 0 223097100.0 79500700.0 53769400.0 89827000.0 False True 76976993.794983 75239801.82371683 66298613.94776321 1.0 0.9774323224950441 0.8612782947115329 26.19792399446971 -6.9391647106992735 0.6673229042092563 1.0013245527433219 0.8307136722618894 0.9980519681198342 0.0026824858272117636 0.08815056124465105 0.05636789913057486 0.0025949005517056623 0.010034555147057377 1.1503640186818904e-07 6.9391647106992735 -0.17061088048143247 STVTLSWKPVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STVTLSWKPVQK 12 1 G3V1C3;Q9BZZ5-2;Q9BZZ5;Q9BZZ5-6;Q9BZZ5-1;Q9BZZ5-5;H0YER7 G3V1C3 API5 Apoptosis inhibitor 5 0 300744100.0 95101200.0 82922900.0 122720000.0 False True 130262683.65329547 79259092.08863957 93736063.49773575 1.0 0.6084558514055642 0.7195926021854561 26.956848613390115 -10.329340572432937 8.385110436189795 1.0000007993824271 0.6640242267955115 0.9241584539010839 0.04537138851359923 6.779846721967864e-07 5.42582646825857e-08 0.04393076210074827 0.014643552675623034 4.684458842082924e-11 10.329340572432937 -0.3359765725869156 STVTLSWKPVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STVTLSWKPVQK 12 1 G3V1C3;Q9BZZ5-2;Q9BZZ5;Q9BZZ5-6;Q9BZZ5-1;Q9BZZ5-5;H0YER7 G3V1C3 API5 Apoptosis inhibitor 5 0 166159600.0 79500700.0 45702900.0 40956000.0 False True 66108354.52817217 45456689.406384625 49519710.240851745 1.0 0.6876088465794923 0.749068867229918 25.978329269903988 -10.741838939632956 6.906053392076579 1.0046435793277093 0.7183388569047164 0.9655210093714203 0.025090948362409993 0.0018136137356046537 6.779615585959044e-05 0.024560984586878727 0.008098068762347015 1.8120119620877744e-11 10.741838939632956 -0.2863047224229929 STVTLSWKPVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STVTLSWKPVQK 12 1 G3V1C3;Q9BZZ5-2;Q9BZZ5;Q9BZZ5-6;Q9BZZ5-1;Q9BZZ5-5;H0YER7 G3V1C3 API5 Apoptosis inhibitor 5 0 389652600.0 99346200.0 169376400.0 120930000.0 False True 128605614.30637147 159950454.4461784 98921980.84658363 1.0 1.2437283963757253 0.7691886655191131 26.93837838430877 -6.7670913573699725 1.5854475530545344 1.1403167389278976 0.7668003570445171 0.7193334665698596 0.10264691314150601 0.27117478518798455 1.344752676919427 0.05104428135423613 0.12184059071610778 1.7096556373183504e-07 6.7670913573699725 -0.37351638188338054 STVVK(ub)AISGVHTVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 STVVKAISGVHTVR 14 1 P41091;Q2VIR3;Q2VIR3-2;H7BZU1 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 6628700.0 1630700.0 3100800.0 1897200.0 True False 2137863.4917212664 2638172.7268237323 1700895.9432274501 1.0 1.2340230033582031 0.7956054957737274 21.027738305402128 -6.761699070106348 1.6060966155476517 1.1356455920140882 0.793868822397843 0.6978668203991453 0.09845591264374101 0.28006735198230526 1.424246624004948 0.048358810643607225 0.11601867837538099 1.731015393203476e-07 6.761699070106348 -0.34177676961624526 STVVK(ub)AISGVHTVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 STVVKAISGVHTVR 14 1 P41091;Q2VIR3;Q2VIR3-2;H7BZU1 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 11017100.0 2919000.0 2662700.0 5435400.0 True False 2826337.9427798153 3725929.995797059 4011705.6814952334 1.0 1.3182889205855048 1.4194005680543502 21.430502547106258 -12.65807048504871 0.17846808948617524 7.181235021023867e-08 1.5065140398139185 0.9994752449795428 0.004093750134037646 7.137875152525514 0.12306933908657663 2.6142332230189975 0.07611741342595392 2.1975031938583406e-13 12.65807048504871 1.5065139680015682 STVVK(ub)AISGVHTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STVVKAISGVHTVR 14 1 P41091;Q2VIR3;Q2VIR3-2;H7BZU1 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 5965400.0 1630700.0 2248500.0 2086200.0 True False 2233613.8580105104 2149153.835204826 1593482.5266376813 1.0 0.9621868289799593 0.7134100287401526 21.09094836692502 -6.933917518368828 0.7139010145550866 1.0032891502290828 0.656838309063299 0.9972537547026634 0.006662088525123105 0.09065410589654985 0.06808448074227169 0.006217690263726631 0.022045268708586557 1.1643471423566295e-07 6.933917518368828 -0.34645084116578384 STVVK(ub)AISGVHTVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STVVKAISGVHTVR 14 1 P41091;Q2VIR3;Q2VIR3-2;H7BZU1 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 10575700.0 2919000.0 5489900.0 2166800.0 True False 2427277.833625798 5460324.819040175 2619867.8618487553 1.0 2.249567290318677 1.0793440394646836 21.210907822540534 -6.630710732297735 2.077807095985537 1.8228292684579375 1.084076594724916 0.11996979461896817 0.5359071957575047 0.5572572893033335 4.585652118229976 0.21087818745616563 0.5936629084461513 2.3403955716911728e-07 6.630710732297735 -0.7387526737330214 STVVK(ub)AISGVHTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 STVVKAISGVHTVR 14 1 P41091;Q2VIR3;Q2VIR3-2;H7BZU1 P41091 EIF2S3;EIF2S3L Eukaryotic translation initiation factor 2 subunit 3;Putative eukaryotic translation initiation factor 2 subunit 3-like protein 1 4781400.0 0.0 0.0 4781400.0 True False 0.0 0.0 3911234.2613069955 0.0 STYGVTK(ub)GK ddPTM_RPMI8226_Bortezomib_1h_R1 1 STYGVTKGK 9 1 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 4682700.0 1364700.0 1966500.0 1351500.0 True False 1789134.9157735985 1673105.8653569631 1211659.7445034264 1.0 0.9351479592770309 0.6772321828952294 20.770830752118407 -6.945007649180398 0.6112071127708328 1.0028480709654992 0.5960728738954056 0.9987489106102765 0.004930877641433893 0.08555465464127672 0.04475238163158516 0.005006411069516456 0.021757371870853894 1.1349908250291269e-07 6.945007649180398 -0.4067751970700936 STYGVTK(ub)GK ddPTM_RPMI8226_Bortezomib_2h_R1 1 STYGVTKGK 9 1 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 4565360.0 1524200.0 2139400.0 901760.0 True False 1475815.1053048978 2993673.5768236145 665562.003779876 1.0 2.028488234103779 0.450979259791743 20.493080556733027 -6.730753295539373 1.7203461349160014 1.618414194215774 0.45176281733963985 0.5628194513525309 0.43232702069918333 0.3348251602664134 1.9416702802869106 0.1991135316989512 0.493691796978878 1.8588600956039084e-07 6.730753295539373 -1.1666513768761342 STYGVTK(ub)GK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STYGVTKGK 9 1 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 4014100.0 1364700.0 1556200.0 1093200.0 True False 1869266.4696307953 1487441.9383347759 835008.6751607294 1.0 0.7957356334694032 0.44670392837338735 20.8340408136413 -6.963002520181958 0.39082808427127363 1.0212394751111127 0.2086425175493452 0.9998658530502357 0.0026458840796994548 0.07864557388026928 0.017292409714180203 0.004504360144911873 0.029349627116313143 1.0889237743629493e-07 6.963002520181958 -0.8125969575617675 down STYGVTK(ub)GK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 STYGVTKGK 9 1 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 3568610.0 1524200.0 1463900.0 580510.0 True False 1267439.8335088876 1456013.680138602 701891.9570250232 1.0 1.148783272897184 0.5537872003610982 20.273485832167303 -6.840497726072575 1.2801801320729698 1.0791437550000256 0.5340364919758437 0.9252850084603331 0.06910599253568822 0.16822441343696803 0.5353435376634476 0.042325919318185155 0.09751866931233316 1.443784163796897e-07 6.840497726072575 -0.5451072630241819 STYGWTANMER ddPTM_RPMI8226_Bortezomib_1h_R1 1 STYGWTANMER 11 0 Q58FG1 Q58FG1 HSP90AA4P Putative heat shock protein HSP 90-alpha A4 0 23540500.0 3460700.0 4202800.0 15877000.0 False True 4537011.213466478 3575758.6223860905 14234200.342938127 1.0 0.7881308760650059 3.137351810083486 22.113310794715385 -6.884883238215135 1.0522196902341217 0.857859505044172 3.3202288322342732 0.9774144099075261 0.15945643950825186 0.123391122122242 0.2469081709132601 0.11617804714667163 0.28477122674673727 1.3035171870842809e-07 6.884883238215135 2.4623693271901015 up STYGWTANMER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 STYGWTANMER 11 0 Q58FG1 Q58FG1 HSP90AA4P Putative heat shock protein HSP 90-alpha A4 0 9452800.0 3460700.0 3504200.0 2487900.0 False True 4740214.311901007 3349372.8571602115 1900309.259908869 1.0 0.7065867989873617 0.4008910008853107 22.176520856238277 -6.98823308358843 0.24513676396004946 1.1039235089828159 7.653398281985405e-11 0.9999869024510265 0.0008852102160267204 0.07417646949977265 0.008314642280996123 0.007032897080227175 0.02892711922783875 1.0274647151580165e-07 6.98823308358843 -1.103923508906282 down SVAGGFVYTYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVAGGFVYTYK 11 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 55186000.0 18041000.0 18079000.0 19066000.0 False True 23651925.709292546 15381683.671390055 17093233.213986184 1.0 0.6503353621369944 0.7226994293860168 24.495454314928185 -10.433638222253444 6.682896430021783 1.0000514367978985 0.6865173957615127 0.9615707788875508 0.02954250674542543 2.264441097150782e-05 1.9190521244702934e-06 0.028609084567312714 0.009534803052521081 3.684357616928479e-11 10.433638222253444 -0.3135340410363858 SVAGGFVYTYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVAGGFVYTYK 11 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 36992200.0 9507700.0 3543500.0 23941000.0 False True 9205883.267751848 4958438.0291083865 17670133.885395255 1.0 0.5386162180089513 1.9194392728499636 23.134124718370522 -6.816617554432184 1.3865038871801856 0.7504360387117824 1.947438249440974 0.8764130753470446 0.2017767840246914 0.19791387253542533 0.748502447523138 0.11438811949648013 0.26390598925962305 1.5253954462808886e-07 6.816617554432184 1.1970022107291918 SVAGGFVYTYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVAGGFVYTYK 11 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 54736000.0 12154000.0 16748000.0 25834000.0 False True 18438506.57642009 13759188.547278747 20727898.576555543 1.0 0.7462203346161752 1.124163634980244 24.136218473880945 -6.72578832539223 1.7385464337646317 0.8465631825257247 1.123772443583399 0.5396230032706594 0.10672311036863803 0.34420590553534275 2.0361616284586574 0.0486856527849015 0.12139232615684022 1.8802330168171175e-07 6.72578832539223 0.2772092610576742 SVAGGFVYTYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVAGGFVYTYK 11 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 55502000.0 18041000.0 14466000.0 22995000.0 False True 24711245.239693142 13826844.287335092 17564054.596890755 1.0 0.5595365248986048 0.7107717327283043 24.558664376451077 -10.468169723321523 7.140368950561787 1.0000581627646046 0.6351541288134546 0.8858424362938664 0.06174151505442183 5.7176036282323665e-05 4.258536459083527e-06 0.059790439913341015 0.019926988297949182 3.402751833581566e-11 10.468169723321523 -0.36490403395115 SVAGGFVYTYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVAGGFVYTYK 11 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 25121000.0 9507700.0 5552300.0 10061000.0 False True 7906073.812526206 5522388.657854738 12164708.58319195 1.0 0.6984995066837334 1.538653555690115 22.9145299938048 -6.809687003448322 1.4161781475057886 0.8356260867804993 1.553199970920501 0.8589213647044786 0.1305286864613531 0.2072337401519404 0.8192624940706097 0.07247997341514376 0.16765926548154578 1.5499332552313314e-07 6.809687003448322 0.7175738841400018 SVAGGFVYTYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVAGGFVYTYK 11 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 77089000.0 12154000.0 36933000.0 28002000.0 False True 15733592.591157403 34877646.08328376 22905923.32478318 1.0 2.21676301081329 1.4558609670404694 23.907344795973394 -10.09605610577473 4.695758956226482 0.9999550797562468 1.8363119889362338 0.6169627213480717 0.3106369586336461 216145733.5045269 7.809725980627627 111258.07569377392 0.10633929339104325 8.015745026346325e-11 10.09605610577473 0.8363569091799871 SVAK(ub)LQDER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVAKLQDER 9 1 O14818;Q8TAA3-5;Q8TAA3;O14818-4;A0A087WYS6 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 1 12015400.0 2773100.0 4149500.0 5092800.0 True False 3635560.9547385992 3530410.7746243137 4565845.9095871635 1.0 0.9710773161491811 1.255884845950947 21.793746553601434 -6.881875720065155 1.0692457292483042 0.9815862872522101 1.2768123496735932 0.9751687516103194 0.020168301500730457 0.12598318483451815 0.2623359709302089 0.014504188402650265 0.035249225329253064 1.3125754586012317e-07 6.881875720065155 0.29522606242138316 SVAK(ub)LQDER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVAKLQDER 9 1 O14818;Q8TAA3-5;Q8TAA3;O14818-4;A0A087WYS6 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 1 19634800.0 5635400.0 6492500.0 7506900.0 True False 5456507.311662003 9084989.107940234 5540617.687827304 1.0 1.6649824858702567 1.0154146913696118 22.379546352614845 -10.092879761285397 4.472634067226283 0.9999710771263068 1.340198588638968 0.26778823122623263 0.26518494170631174 184461504.26880834 2.343276302416982 56649.96314899208 0.09077985904293716 8.074585521765599e-11 10.092879761285397 0.3402275115126612 SVAK(ub)LQDER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVAKLQDER 9 1 O14818;Q8TAA3-5;Q8TAA3;O14818-4;A0A087WYS6 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 1 23767100.0 2688900.0 4824800.0 16253400.0 True False 4079257.884921503 3963776.743665539 13040908.365881698 1.0 0.9716906494970995 3.1968825540757995 21.95987528448033 -6.904020608580731 0.9355134895865455 0.9174112783363845 3.4504894690271817 0.9884622672443439 0.11196356857129947 0.1085055811506648 0.1612046809896421 0.08903810601701372 0.23669933216981076 1.2473243235439963e-07 6.904020608580731 2.533078190690797 up SVAK(ub)LQDER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVAKLQDER 9 1 O14818;Q8TAA3-5;Q8TAA3;O14818-4;A0A087WYS6 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 1 8947100.0 2773100.0 2412800.0 3761200.0 True False 3798390.010209687 2306194.5179373827 2872882.0243455335 1.0 0.6071505326568798 0.7563420334993295 21.856956615124325 -10.103189209793701 4.884263199865849 1.0000131225573343 0.6817462830768694 0.8585038253663224 0.06090717517765628 8.794292536637576e-06 1.6147206241168588e-06 0.05897557453430544 0.019657706259636906 7.885165084849716e-11 10.103189209793701 -0.31826683948046497 SVAK(ub)LQDER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVAKLQDER 9 1 O14818;Q8TAA3-5;Q8TAA3;O14818-4;A0A087WYS6 O14818 PSMA7;PSMA8 Proteasome subunit alpha type-7;Proteasome subunit alpha type-7-like 1 19554110.0 5635400.0 9337510.0 4581200.0 True False 4686084.79054979 9287206.980279386 5539107.738924467 1.0 1.981869171255387 1.1820331868716778 22.15995162804912 -10.126903200594455 4.448392642302832 0.9999307587981937 1.5819511789156897 0.41378061353003703 0.3265316733818188 227899702.27791694 27.130211713895417 177487.20635361172 0.11178047701598684 7.466151520719699e-11 10.126903200594455 0.582020420117496 SVASLFDAFHAGFHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVASLFDAFHAGFHK 15 0 Q5GLZ8-6;Q5GLZ8-3;Q5GLZ8-2;Q5GLZ8 Q5GLZ8-6 HERC4 Probable E3 ubiquitin-protein ligase HERC4 0 5515400.0 1048400.0 1780500.0 2686500.0 False True 1374462.5527200422 1514856.3403346404 2408526.750727676 1.0 1.1021444981071045 1.7523407574555123 20.390436170434015 -6.9345967042675865 0.708044039120325 0.9915954087794053 1.9029209117051769 0.9973670829205535 0.01709718746645879 0.09032015892190062 0.06649563192454518 0.016026744343063584 0.057417426009453536 1.1625276623732271e-07 6.9345967042675865 0.9113255029257715 SVASLFDAFHAGFHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVASLFDAFHAGFHK 15 0 Q5GLZ8-6;Q5GLZ8-3;Q5GLZ8-2;Q5GLZ8 Q5GLZ8-6 HERC4 Probable E3 ubiquitin-protein ligase HERC4 0 6454200.0 1048400.0 1960500.0 3445300.0 False True 1436021.8119446964 1873878.6274934649 2631591.098180805 1.0 1.3049095855694643 1.8325564948188628 20.453646231956906 -6.962773374829005 0.39440475727514723 0.9691425914136614 2.187416905463541 0.9998596354373563 0.004074612307318783 0.07872489118246892 0.0175766308095815 0.006798594715296152 0.04430403111664608 1.0894984711914373e-07 6.962773374829005 1.2182743140498795 SVAVNPK(ub)EIASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVAVNPKEIASK 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 27949400.0 3008600.0 3738800.0 21202000.0 True False 4564266.15812222 3071581.928622266 17011415.4068333 1.0 0.6729629303401409 3.7270866372595473 22.12195149193391 -6.880400222454566 1.0775111510527078 0.7961907875012322 3.945244960576207 0.9740091123763772 0.22073325914066066 0.12727860464275736 0.27011959140872505 0.15774106568200336 0.381866124836553 1.3170424635834313e-07 6.880400222454566 3.1490541730749753 up SVAVNPK(ub)EIASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVAVNPKEIASK 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 21289700.0 3008600.0 5332100.0 12949000.0 True False 3894692.0083722346 5035363.947707392 10592414.86796006 1.0 1.2928785990992637 2.7197053952379413 21.89307781402636 -6.940386541892488 0.6559565518914586 0.984084654733729 3.1088916333381102 0.9982141059608417 0.03174648562151474 0.08759070734724345 0.053809707284527844 0.030994103604427153 0.12259645376138295 1.14713216705651e-07 6.940386541892488 2.124806978604381 up SVAWAPSGNLLATCSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVAWAPSGNLLATCSR 16 0 O76071 O76071 CIAO1 Probable cytosolic iron-sulfur protein assembly protein CIAO1 0 13877800.0 4404800.0 4567400.0 4905600.0 False True 5774735.456143885 3885961.7235857532 4398015.569837963 1.0 0.6729246305908926 0.761596025175284 22.46132342670116 -10.009261797395919 6.832766562077506 1.000000048073295 0.7172603278830882 0.931301809348867 0.03619994525212662 2.6507909641569696e-08 3.821969721596303e-09 0.03505045254126431 0.011683482091258565 9.788997162135825e-11 10.009261797395919 -0.28273972019020666 SVAWAPSGNLLATCSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVAWAPSGNLLATCSR 16 0 O76071 O76071 CIAO1 Probable cytosolic iron-sulfur protein assembly protein CIAO1 0 19254800.0 3075700.0 11984000.0 4195100.0 False True 4666061.76378931 9845361.568580627 3365936.6462223544 1.0 2.1099938378409306 0.7213656433662113 22.15377397345786 -6.693848208319359 1.853049238675967 1.6933786050384543 0.7259678942972928 0.3883886013807002 0.46908952671423815 0.408430537536136 2.7221009347501597 0.20230509632522176 0.5242159232550168 2.02372637428857e-07 6.693848208319359 -0.9674107107411615 SVAWAPSGNLLATCSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVAWAPSGNLLATCSR 16 0 O76071 O76071 CIAO1 Probable cytosolic iron-sulfur protein assembly protein CIAO1 0 12404100.0 4404800.0 3759100.0 4240200.0 False True 6033373.595244186 3593010.5323186377 3238752.0896601942 1.0 0.5955226334982525 0.5368061563787703 22.52453348822405 -13.999999999999998 0.2718021418178945 4.152332439643119 0.5176539123723238 0.9995872153029537 0.004183533286469189 14.972168862248417 0.1650537717687681 26.10770283872838 0.024168565436412413 1.0000000000000041e-14 13.999999999999998 -3.634678527270795 SVCLIGDK(ub)EQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVCLIGDKEQR 11 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 1 4029850.0 928750.0 1344700.0 1756400.0 True False 1217600.244027794 1144076.0015995463 1574664.5765784818 1.0 0.9396154503180524 1.2932525139527953 20.21560912241892 -6.862919224474617 1.1708015323509926 0.9669442869800166 1.311365095995209 0.9570965728040356 0.031992139560597446 0.14383025453523932 0.37298124379585923 0.0212843978318862 0.04986228053303178 1.3711367636330972e-07 6.862919224474617 0.34442080901519245 SVCLIGDK(ub)EQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVCLIGDKEQR 11 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 1 3445000.0 928750.0 857550.0 1658700.0 True False 1272133.9735250256 819660.6054613724 1266949.2219988126 1.0 0.6443194054397666 0.9959243667458654 20.27881918394181 -10.8880395525431 10.168416498999614 1.0130772932832155 0.8201218860928224 0.25869247939243556 0.1435421243718275 0.04174640726407262 0.0004596525876693653 0.13634258242516226 0.046328021430943465 1.2940779803947705e-11 10.8880395525431 -0.19295540719039306 SVCLIGDK(ub)EQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVCLIGDKEQR 11 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 1 9482500.0 3092100.0 2713000.0 3677400.0 True False 4002784.404403307 2562019.165081332 3008150.9333104 1.0 0.6400592453250679 0.7515146031850356 21.932572481558612 -10.601679633771663 9.483392876042103 1.0000507866250716 0.695786924255052 0.9085361209982631 0.045501459309369906 4.8866625751018706e-05 2.0525322633888555e-06 0.04406389921842876 0.01468553284444367 2.502190473172218e-11 10.601679633771663 -0.3042638623700197 SVCTEAGMFAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVCTEAGMFAIR 12 0 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 0 11449500.0 2788400.0 3111600.0 5549500.0 False True 3655619.402904011 2647361.408921802 4975290.9745629 1.0 0.7241895605485482 1.3609980761702236 21.80168444439045 -6.788990673874958 1.5002628664021245 0.8456436613765203 1.3675924211343509 0.7980488183117502 0.11717848601148917 0.23687046145827115 1.0532498571477578 0.061479988196961384 0.1440524573499275 1.625583663478688e-07 6.788990673874958 0.5219487597578306 SVCTEAGMFAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVCTEAGMFAIR 12 0 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 0 10951000.0 2788400.0 4677300.0 3485300.0 False True 3819346.833676641 4470641.420237277 2662143.922006665 1.0 1.1705251224680415 0.697015494516896 21.86489450591334 -6.809293101181831 1.4174316965392633 1.0930142583360067 0.6888598735764379 0.8579812622207403 0.07379341806766336 0.2077729520771385 0.8228591461717523 0.040936856295982614 0.0947291832257666 1.551339672308134e-07 6.809293101181831 -0.4041543847595689 SVDEALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVDEALR 7 0 P32119 P32119 PRDX2 Peroxiredoxin-2 0 8750200.0 1010400.0 4623400.0 3116400.0 False True 1324644.18472752 3933606.741872052 2793944.822619666 1.0 2.969557249580345 2.1092040072590374 20.33717345589315 -10.164552776919145 4.9694781277055045 0.9998914573923273 2.53938062842286 0.8101933220740625 0.3512377403837208 0.00042242765261152316 7.101753119266258e-05 0.34010792218259733 0.11336149325389976 6.846162811736598e-11 10.164552776919145 1.5394891710305325 SVDEALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVDEALR 7 0 P32119 P32119 PRDX2 Peroxiredoxin-2 0 6403200.0 2202900.0 1422300.0 2778000.0 False True 2132970.1453064964 1990231.8071965163 2050358.4617863912 1.0 0.9330800112584466 0.9612691796451589 21.024432342072657 -10.042695737556418 4.204152237325072 1.0000048401861255 0.9471745954582053 0.8240150977602375 0.011508179859521682 16056344.106534272 308285003895.4689 3392146.920348997 0.004203410023177409 9.063673705830118e-11 10.042695737556418 -0.052830244727920195 SVDEALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVDEALR 7 0 P32119 P32119 PRDX2 Peroxiredoxin-2 0 8082600.0 1010400.0 3506500.0 3565700.0 False True 1383972.1850333102 3351571.235555128 2723555.0978966407 1.0 2.421704187266206 1.967926181862599 20.400383517416042 -10.49847919803216 5.848582835382834 0.9986064749565943 2.194815184564403 0.9023805397890031 0.1852540949561255 0.0033688931597268207 0.0002888852524825931 0.17951703668016325 0.05979050204848324 3.17337065925915e-11 10.49847919803216 1.196208709607809 SVDETLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVDETLR 7 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5;Q13162;H7C3T4 Q06830;Q13162 PRDX1;PRDX4 Peroxiredoxin-1;Peroxiredoxin-4 0 39600100.0 4042100.0 21216000.0 14342000.0 False True 5299232.243752085 18050655.49932025 12858027.418178402 1.0 3.4062774887064786 2.426394395780315 22.337351925534865 -10.495715228119886 6.325956466161498 0.9987629474995807 2.9163359422433968 0.8360539981831487 0.40003559754154916 0.0069815715770112615 0.0005565473791479361 0.38745624630721376 0.12911093393071268 3.1936312693934184e-11 10.495715228119886 1.917572994743816 SVDETLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVDETLR 7 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5;Q13162;H7C3T4 Q06830;Q13162 PRDX1;PRDX4 Peroxiredoxin-1;Peroxiredoxin-4 0 31728400.0 10305000.0 5171400.0 16252000.0 False True 9977873.415671805 7236366.9884947315 11995113.650450852 1.0 0.7252414103719625 1.2021713596416905 23.25030093603061 -6.750489823502147 1.6480964786920476 0.8385346908695495 1.2031513754055299 0.6510610440794936 0.1154579695776142 0.2991860652380448 1.5990609914974765 0.05533809984759866 0.13427351944771088 1.7762748899220857e-07 6.750489823502147 0.3646166845359804 SVDETLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVDETLR 7 0 Q06830;A0A0A0MSI0;A0A0A0MRQ5;Q13162;H7C3T4 Q06830;Q13162 PRDX1;PRDX4 Peroxiredoxin-1;Peroxiredoxin-4 0 50291100.0 4042100.0 26057000.0 20192000.0 False True 5536573.603645231 24905715.581023864 15423065.467293672 1.0 4.49839871443706 2.7856697248889213 22.400561987057756 -9.309237719010325 10.760482917957727 0.9999888353710261 3.6420342196647497 0.7603509226056503 0.6992186820406474 0.0 0.0 0.6770155777117025 0.2256718592372341 4.906392422952995e-10 9.309237719010325 2.6420453842937235 SVDFHFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVDFHFR 7 0 Q9ULW0;Q9ULW0-2 Q9ULW0 TPX2 Targeting protein for Xklp2 0 9598900.0 2574700.0 1249600.0 5774600.0 False True 3375456.6334302714 1063164.5509026502 5177099.78587457 1.0 0.31496910384602417 1.5337479778590424 21.68665125318338 -6.754203075272764 1.6343056706357293 0.5992342673758505 1.5369645679073358 0.6668288782850684 0.28793558435140254 0.29278093581381465 1.5397948113321176 0.13910472352586556 0.3362299293847 1.7611523423636718e-07 6.754203075272764 0.9377303005314853 SVDFHFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVDFHFR 7 0 Q9ULW0;Q9ULW0-2 Q9ULW0 TPX2 Targeting protein for Xklp2 0 3947860.0 1248800.0 521360.0 2177700.0 False True 1209157.5275585586 729541.7668564827 1607295.0404003698 1.0 0.6033471654677778 1.3292685227256542 20.205570778694536 -6.758329132573124 1.6186392113719503 0.7691217637209983 1.3317139996238692 0.6841354823666475 0.16679659081313278 0.2857439660033803 1.4751034819772324 0.08131805642086302 0.19575326977170987 1.7444995727778875e-07 6.758329132573124 0.5625922359028709 SVDFHFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVDFHFR 7 0 Q9ULW0;Q9ULW0-2 Q9ULW0 TPX2 Targeting protein for Xklp2 0 5903500.0 2574700.0 1180000.0 2148800.0 False True 3526636.168651291 1127863.6982618147 1641297.6959251496 1.0 0.3198128880681074 0.4654003467992671 21.749861314706273 -10.045736070200698 7.431506507159511 1.0000000491871175 0.39260661743873376 0.9586907214501057 0.059435831139974304 4.8401124389885716e-08 6.346583262999176e-09 0.05754850033093494 0.019182832014426384 9.00044391076136e-11 10.045736070200698 -0.6073934317483838 SVDFHFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVDFHFR 7 0 Q9ULW0;Q9ULW0-2 Q9ULW0 TPX2 Targeting protein for Xklp2 0 3591200.0 1248800.0 1298000.0 1044400.0 False True 1038432.5312202452 1291007.416367171 1262779.2112400036 1.0 1.2432270538078476 1.2160435784461916 19.985976054128813 -10.166435110248292 4.973067444958305 0.9999835690045875 1.2296353161274751 0.9895995182603062 0.011097607346840805 2.0218461660968915e-06 3.389182834136047e-07 0.010745980653261869 0.003581737369529675 6.816554160998533e-11 10.166435110248292 0.2296517471228876 SVDPTLALSVYLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVDPTLALSVYLR 13 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 5216380.0 2025500.0 945080.0 2245800.0 False True 1961201.611202644 1322455.372527093 1657557.6074441627 1.0 0.6743087324490518 0.8451745083095862 20.903306421290427 -10.124268779978237 4.76713920052994 1.0000160674084932 0.7597416203771877 0.7249909755047177 0.06975566090117213 97345281.65796988 0.5562561461373305 17168.610412041624 0.023879218117179975 7.511578669637865e-11 10.124268779978237 -0.24027444703130552 SVDPTLALSVYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVDPTLALSVYLR 13 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 161419000.0 46057000.0 46300000.0 69062000.0 False True 69871836.21772085 38037403.25644887 55411865.42905004 1.0 0.5443882015340803 0.7930500818153183 26.058207718713483 -10.087862945268126 5.237653127291934 1.0000055301746293 0.6687191416742506 0.7029587099645669 0.1015157875299142 6.555744796876911e-06 1.1416771243758804e-06 0.0982938793498425 0.03276407953981462 8.168401092387465e-11 10.087862945268126 -0.3312863885003787 SVDPTLALSVYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVDPTLALSVYLR 13 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 6890630.0 2025500.0 966030.0 3899100.0 False True 1684292.994864356 960825.8046480585 4714383.782598522 1.0 0.5704623884192063 2.79902831453514 20.683711696724703 -6.856743202162728 1.2019901215903472 0.7686620523006829 2.90046855909599 0.949564177895608 0.21680278770326503 0.15019907205542002 0.41420375680340754 0.14084783897933154 0.32768718359174615 1.3907747516718408e-07 6.856743202162728 2.131806506795307 up SVDPTLALSVYLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVDPTLALSVYLR 13 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 106558000.0 46057000.0 18736000.0 41765000.0 False True 59621694.41919826 17693325.129732326 34164198.5450886 1.0 0.2967598506230151 0.573016229711306 25.829334040805932 -10.382142518291603 5.909318164753329 1.0001261880004801 0.4348880401676463 0.8480091523351052 0.11278119449253354 0.00018753807001036898 1.9608460200852682e-05 0.10922398120418413 0.03639997400291321 4.1481789345147224e-11 10.382142518291603 -0.5652381478328339 SVEEIAPDPSEAK(ub)RPEPPSTSTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVEEIAPDPSEAKRPEPPSTSTLK 24 2 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 675564000.0 284754000.0 186200000.0 204610000.0 True False 373315251.5616587 158419685.80191523 183438919.95771056 1.0 0.4243589972261013 0.4913780489555296 28.475819209349574 -10.32597302125717 5.727458677294502 1.0000747554664449 0.45786852309215853 0.9886681933683955 0.02736041329705884 2.6120949319551185e-05 3.0739993204101793e-06 0.02649523308561083 0.008830535420403532 4.720923671323365e-11 10.32597302125717 -0.5422062323742863 SVEEIAPDPSEAK(ub)RPEPPSTSTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVEEIAPDPSEAKRPEPPSTSTLK 24 2 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 896478000.0 249780000.0 323133000.0 323565000.0 True False 241850870.62265953 452161692.01633364 238813619.7580683 1.0 1.8695888538760117 0.987441637663856 27.84954249035273 -10.123712427956724 4.405645615519586 0.9999439410339669 1.4285152457908885 0.2393250969049261 0.3601350930372814 251273696.86977702 17.65117903351776 150564.72118679088 0.12328382136649238 7.521207527699162e-11 10.123712427956724 0.4285713047569216 SVEEIAPDPSEAK(ub)RPEPPSTSTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVEEIAPDPSEAKRPEPPSTSTLK 24 2 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 1434975000.0 600790000.0 435040000.0 399145000.0 True False 911442353.6323364 357403713.0169661 320253815.79853153 1.0 0.3921298056784598 0.35137034670622475 29.76357617152489 -13.96857418572056 0.38402873286308065 9.99945673403057 0.34801081337606515 0.9998133079638574 0.004052966962728928 23.927095370610573 0.20233083972341395 178.14130581655843 0.010920582827842949 1.0750429470169288e-14 13.96857418572056 -9.651445920654504 SVEEIAPDPSEAK(ub)RPEPPSTSTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVEEIAPDPSEAKRPEPPSTSTLK 24 2 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 825272000.0 284754000.0 277449000.0 263069000.0 True False 390035248.9875049 265190385.77884972 200937520.2761231 1.0 0.6799138961600502 0.5151778481502329 28.539029270872465 -13.999999999667986 0.08476299230599334 2.6803917435549205 0.06382128657354982 0.9998662920141657 0.002327510079545241 12.21224370307226 0.08326815195123803 3.770098943208221 0.4076467920789531 1.0000000007644894e-14 13.999999999667986 -2.616570456981371 SVEEIAPDPSEAK(ub)RPEPPSTSTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVEEIAPDPSEAKRPEPPSTSTLK 24 2 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 718156000.0 249780000.0 304421000.0 163955000.0 True False 207703137.13019958 302781023.6501627 198237232.45773163 1.0 1.457758548251311 0.9544257982654628 27.629947765787005 -6.667403818337314 1.9475708839709078 1.292849106408153 0.9565242952660143 0.2672522510936255 0.19456536852708314 0.4670562243813383 3.413158049847019 0.0805174406693566 0.21577523859709993 2.1507809524486758e-07 6.667403818337314 -0.33632481114213875 SVEEIAPDPSEAK(ub)RPEPPSTSTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVEEIAPDPSEAKRPEPPSTSTLK 24 2 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 1552920000.0 600790000.0 405800000.0 546330000.0 True False 777734498.3414059 383216873.2731313 446903545.81918496 1.0 0.4927348267183446 0.5746222480451234 29.53470249361734 -10.75148211629418 6.990660496876839 1.0085384934988737 0.533678537381734 0.9773954853568956 0.033430399767151515 0.004446244971013669 0.00015806373669436055 0.03235025370357342 0.01078961512960285 1.7722210214868033e-11 10.75148211629418 -0.4748599561171397 SVEEIAPDPSEAKRPEPPSTSTLK(ub)QVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVEEIAPDPSEAKRPEPPSTSTLKQVTK 28 3 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 131544000.0 41608000.0 44543000.0 45393000.0 True False 63122377.95225323 36593953.63395249 36421053.65354131 1.0 0.57973027666405 0.5769911532973421 25.911648219932083 SVEEIAPDPSEAKRPEPPSTSTLK(ub)QVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVEEIAPDPSEAKRPEPPSTSTLKQVTK 28 3 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 152671000.0 41608000.0 53196000.0 57867000.0 True False 53862376.21629719 50235595.83695778 47335799.76556072 1.0 0.932665793191611 0.8788286572332522 25.682774542024532 -6.973656297686938 0.14652379323545722 1.0657176083263478 0.7443650256255753 0.9999986738142534 5.679237884135251e-05 0.0751331711928578 0.004463922002857054 0.002845392252641851 0.006813834836424705 1.0625361196893177e-07 6.973656297686938 -0.3213525827007725 SVEEIAPDPSEAKRPEPPSTSTLKQVTK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVEEIAPDPSEAKRPEPPSTSTLKQVTK 28 3 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 47993000.0 15777000.0 18986000.0 13230000.0 True False 23934862.45319891 15597799.961704927 10615084.701084994 1.0 0.6516770251846703 0.44349888042353386 24.512610179537734 -9.333906791173085 0.1256187715344471 1.6172240114034693 7.164934206435558e-15 0.9998960348596568 0.0023408606962253735 0.7785235508431557 0.04648790173947947 0.37356991778996995 0.20490027558855833 4.6354639597048364e-10 9.333906791173085 -1.6172240114034622 SVEEIAPDPSEAKRPEPPSTSTLKQVTK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVEEIAPDPSEAKRPEPPSTSTLKQVTK 28 3 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 56167000.0 15777000.0 22014000.0 18376000.0 True False 20423637.51116424 20788901.548138734 15031756.553682467 1.0 1.017884377196512 0.7359980094371342 24.283736501630184 -6.891768988567228 1.0118220046172983 1.0145099648161586 0.7108924383122004 0.9820078801618275 0.01728649015583759 0.1177210393913507 0.21353976277332157 0.01298596454966918 0.03258854370430824 1.2830128658490074e-07 6.891768988567228 -0.30361752650395823 SVELNPTQK(ub)DLVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVELNPTQKDLVLK 14 1 J3KNE0;A6NKT7;Q7Z3J3;C9J6W1;Q7Z3J3-2;C9J1W9;C9JF75;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD5;RGPD6;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;E3 SUMO-protein ligase RanBP2 1 5859100.0 2034800.0 1935500.0 1888800.0 True False 2667642.505031228 1646730.9445199072 1693365.094648962 1.0 0.6172982104664096 0.6347796196286575 21.347133910968225 -10.39219190074095 9.01226060431745 1.0000012448052873 0.626038915053421 0.9983637471970948 0.007136755405386989 1.7849931706717188e-07 1.203106523141651e-08 0.006910156665265467 0.0023033779025849613 4.053293938712059e-11 10.39219190074095 -0.3739623297518663 SVELNPTQK(ub)DLVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVELNPTQKDLVLK 14 1 J3KNE0;A6NKT7;Q7Z3J3;C9J6W1;Q7Z3J3-2;C9J1W9;C9JF75;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD5;RGPD6;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;E3 SUMO-protein ligase RanBP2 1 11180300.0 2235400.0 4436500.0 4508400.0 True False 2164438.4505960946 6208017.586041867 3327514.7908991226 1.0 2.8681885522464983 1.537357086768955 21.045561345026986 -10.486252627565019 5.146085500040377 0.997268534616232 2.202772819507749 0.5213204147298947 0.5433096706768036 0.017046997786643887 0.001701846062128782 0.5266949042468855 0.1753524421970468 3.26397912427931e-11 10.486252627565019 1.2055042848915172 SVELNPTQK(ub)DLVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVELNPTQKDLVLK 14 1 J3KNE0;A6NKT7;Q7Z3J3;C9J6W1;Q7Z3J3-2;C9J1W9;C9JF75;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD5;RGPD6;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;E3 SUMO-protein ligase RanBP2 1 34936000.0 4118000.0 5710000.0 25108000.0 True False 6247307.06612621 4691005.887566374 20145392.79477269 1.0 0.7508844751687774 3.2246522512081857 22.57480301196814 -6.882101191971588 1.067972908720894 0.8408428698766642 3.4072143135033564 0.9753427531754928 0.1746270659258278 0.1257868265090586 0.26115649921690287 0.12570643815439173 0.30569000464083224 1.3118941879588992e-07 6.882101191971588 2.566371443626692 up SVELNPTQK(ub)DLVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVELNPTQKDLVLK 14 1 J3KNE0;A6NKT7;Q7Z3J3;C9J6W1;Q7Z3J3-2;C9J1W9;C9JF75;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD5;RGPD6;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;E3 SUMO-protein ligase RanBP2 1 6031400.0 2034800.0 1620500.0 2376100.0 True False 2787120.54840239 1548900.9517231109 1814914.117315595 1.0 0.5557351843324319 0.6511789087687381 21.410343972491116 -10.82543606692755 6.988894046311034 1.0238935898429877 0.6034570465505852 0.9583605960210613 0.038964737336626046 0.013400861797020132 0.0003347173688851333 0.034851917461784364 0.012575814899508245 1.4947340679753818e-11 10.82543606692755 -0.42043654329240254 SVELNPTQK(ub)DLVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVELNPTQKDLVLK 14 1 J3KNE0;A6NKT7;Q7Z3J3;C9J6W1;Q7Z3J3-2;C9J1W9;C9JF75;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD5;RGPD6;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;E3 SUMO-protein ligase RanBP2 1 9100800.0 2235400.0 4501200.0 2364200.0 True False 1858834.145011 4476951.142181755 2858543.289174276 1.0 2.4084726193553228 1.5378151390463939 20.825966620461262 -10.29160085891061 5.43901461178723 0.9998634839304279 1.9731438792008973 0.6248647635987488 0.3554444279158312 0.0005884871697399564 7.664739001109861e-05 0.3442048496651384 0.11471919581833334 5.109743984920641e-11 10.29160085891061 0.9732803952704694 SVELNPTQK(ub)DLVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVELNPTQKDLVLK 14 1 J3KNE0;A6NKT7;Q7Z3J3;C9J6W1;Q7Z3J3-2;C9J1W9;C9JF75;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD5;RGPD6;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;E3 SUMO-protein ligase RanBP2 1 28188200.0 4118000.0 6179200.0 17891000.0 True False 5330832.177915599 5835322.088046649 14635021.577162212 1.0 1.0946362393888582 2.745354025172976 22.34592933406059 -6.9186889937293 0.8343906848534302 0.9618284373869828 3.00368380279085 0.9938089556039088 0.0630562078339873 0.09894940677757448 0.10965616547722801 0.05395551243759631 0.15965168178183023 1.205899197845052e-07 6.9186889937293 2.041855365403867 up SVEVETQK(ub)LAYMELQQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVEVETQKLAYMELQQK 17 1 P49454 P49454 CENPF Centromere protein F 1 10870500.0 1618700.0 2172500.0 7079300.0 True False 1567315.2545315842 3039990.5794378365 5225018.955552342 1.0 1.9396165325695012 3.3337383404169816 20.579863966368055 -6.965438015820748 0.3504535024136036 0.865975947790147 4.454454355686743 0.9999218920152626 0.008473295402799057 0.07781263694925258 0.014337609663437043 0.01911453064712716 0.11979265478663839 1.0828342503691402e-07 6.965438015820748 3.5884784078965963 SVEVETQK(ub)LAYMELQQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVEVETQKLAYMELQQK 17 1 P49454 P49454 CENPF Centromere protein F 1 56958000.0 3780000.0 18765000.0 34413000.0 True False 5734536.355016283 15416239.138385814 27611255.46624627 1.0 2.688314832096315 4.814906342357275 22.45124541644432 -6.967997144663927 0.3022206247423886 0.6407769922231397 6.929290526705089 0.9999622757284831 0.009586760126340322 0.07695808619740013 0.011343915970951114 0.03489802372743671 0.19028062478883037 1.0764722910397226e-07 6.967997144663927 6.288513534481949 SVEVETQK(ub)LAYMELQQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVEVETQKLAYMELQQK 17 1 P49454 P49454 CENPF Centromere protein F 1 9425900.0 1618700.0 1756100.0 6051100.0 True False 1346020.770568717 1746639.5407414425 7316357.0328747425 1.0 1.2976319377326229 5.435545418651642 20.36026924180233 -6.921379780160146 0.8144231193851923 0.9131597092844365 6.1244789392694114 0.9945557393747576 0.1493732914153584 0.0973669443633127 0.10145585694600019 0.12964937741097657 0.3936382938418906 1.198450828134389e-07 6.921379780160146 5.211319229984975 up SVFALTNGIYPHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVFALTNGIYPHK 13 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 405847000.0 106325000.0 154587000.0 144935000.0 False True 139393104.65276462 131523222.1754066 129938516.51469049 1.0 0.9435418093530358 0.9321732006642223 27.054583956393447 -13.99999999933435 0.22529734868878806 1.3488215090680375 0.9263924118074514 0.9995037074144192 0.0006607210929160643 13.149203964106004 0.150325736926166 2.046465897745092 0.006078946513475125 1.0000000015327173e-14 13.99999999933435 -0.4224290972605862 SVFALTNGIYPHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVFALTNGIYPHK 13 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 379343000.0 111479000.0 58437000.0 209427000.0 False True 107940160.16551948 81771198.84492926 154571786.02467182 1.0 0.7575604735025244 1.4320136804285417 26.685656492246835 -6.809479961946816 1.4166291350794096 0.8677882907937782 1.4436821473398014 0.858475024497678 0.10493909452141396 0.20751887747282785 0.8208852824887709 0.05824699625867088 0.13477487792259096 1.5506723321146137e-07 6.809479961946816 0.5758938565460232 SVFALTNGIYPHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVFALTNGIYPHK 13 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 407906000.0 108671000.0 176195000.0 123040000.0 False True 164861851.91427895 144751625.63218164 98721090.06965221 1.0 0.8780177096848715 0.5988109979559305 27.296682365144676 -6.957323521174691 0.4716494128741205 1.007257649584733 0.45809322890459164 0.999657667788364 0.003106976755485626 0.08067152656686208 0.024772438586936753 0.003872550889373552 0.023041833476889487 1.1032564593238248e-07 6.957323521174691 -0.5491644206801414 SVFALTNGIYPHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVFALTNGIYPHK 13 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 327853000.0 106325000.0 93408000.0 128120000.0 False True 145636225.8250856 89280925.70105049 97860694.71422672 1.0 0.613040644216365 0.6719529715893693 27.11779401791634 -10.468483218110853 6.092534205392138 1.0002065359941799 0.6424968079028968 0.9800401321692377 0.024050856937276596 6.751079320227874e-05 5.889662179007945e-06 0.023300398618617178 0.007762380698340754 3.400296448831866e-11 10.468483218110853 -0.3577097280912831 SVFALTNGIYPHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVFALTNGIYPHK 13 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 249842500.0 111479000.0 68530500.0 69833000.0 False True 92699727.85706426 68161312.59426087 84434757.4286894 1.0 0.7352913991221235 0.9108414812056537 26.46606176768111 -10.249612052783712 4.67153814145482 1.0000552513766612 0.8230664401632406 0.5752690447696062 0.0716680209036293 4.1254038462445714e-05 6.62668975373973e-06 0.06941390750972022 0.02313075428430034 5.6284387870740135e-11 10.249612052783712 -0.17698881121342058 SVFALTNGIYPHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVFALTNGIYPHK 13 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 463046000.0 108671000.0 173924000.0 180451000.0 False True 140676751.72565946 164244976.50851682 147610769.58361736 1.0 1.1675346103300628 1.049290431950549 27.067808687237125 -10.739959220838514 6.581572030383483 0.9978933017951049 1.108412521140306 0.5284855340128745 0.0482729836807406 0.001519714271352247 6.004447380927307e-05 0.04760074790190443 0.015580038488937546 1.819871731974124e-11 10.739959220838514 0.11051921934520104 SVFGHICSHLTPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVFGHICSHLTPR 13 0 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 0 49691000.0 14973600.0 11342800.0 23374600.0 False True 19630534.604548678 9650498.45388811 20956020.616995774 1.0 0.4916065022320865 1.0675216462082475 24.226596126920306 -6.673636158063469 1.9242099929080627 0.6765235406419748 1.065250065581013 0.2954045713104225 0.21577351029547087 0.4528015970109764 3.235495547946716 0.09015982202262986 0.23977202899540925 2.1201365931411766e-07 6.673636158063469 0.38872652493903825 SVFGHICSHLTPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVFGHICSHLTPR 13 0 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 0 6436400.0 3222100.0 1026200.0 2188100.0 False True 3119816.1991883693 1435967.011562303 1614970.9684070589 1.0 0.46027295195655266 0.5176493951237252 21.57302960599812 -10.199439186375939 5.789983223193508 1.0000118364128496 0.48896117354346735 0.990634431197633 0.023423834835933625 3.5790644621893045e-06 4.948800705649419e-07 0.022680555343938417 0.007560010185318065 6.317726392968632e-11 10.199439186375939 -0.5110506628693823 SVFGHICSHLTPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVFGHICSHLTPR 13 0 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 0 30389300.0 14973600.0 7331000.0 8084700.0 False True 20509744.566324983 7007092.179624887 6175260.369623078 1.0 0.3416469745376476 0.3010890920485796 24.289806188443197 -13.783557431778304 0.3981573404674868 9.99999999258034 0.29856828468692675 0.9998312423923145 0.004161407432660061 22.13167697174532 0.20741487672267586 170.8082152240238 0.010434871018871202 1.6460482759485292e-14 13.783557431778304 -9.701431707893414 SVFLTFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVFLTFLR 8 0 Q9H1I8;Q9H1I8-3;B1AH59;Q9H1I8-2 Q9H1I8 ASCC2 Activating signal cointegrator 1 complex subunit 2 0 3225520.0 905520.0 1251900.0 1068100.0 False True 1187145.4890681547 1065121.3998679796 957583.2579386667 1.0 0.8972121864389533 0.8066267081470512 20.1790653227495 -6.9726137101976216 0.18545339490562093 1.0651637065832 0.6362121969516273 0.9999962344630153 0.00015318424835773192 0.07546365437920992 0.005885040014881109 0.0033256024798438977 0.010002666409196868 1.0650899574158371e-07 6.9726137101976216 -0.4289515096315727 SVFLTFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVFLTFLR 8 0 Q9H1I8;Q9H1I8-3;B1AH59;Q9H1I8-2 Q9H1I8 ASCC2 Activating signal cointegrator 1 complex subunit 2 0 4746820.0 905520.0 1138900.0 2702400.0 False True 1240315.2147578807 1088579.6321613404 2064148.7776750382 1.0 0.8776636932361099 1.6642130589988582 20.242275384272393 -6.867176027794817 1.1490060516754639 0.9318694276209057 1.707856359771112 0.9617784620202239 0.06756124982751865 0.13958719366669234 0.3462084824792523 0.04570914179513084 0.10771272952719811 1.357763007930644e-07 6.867176027794817 0.7759869321502063 SVGDGETVEFDVVEGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVGDGETVEFDVVEGEK 17 0 P67809;H0Y449;Q9Y2T7;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX2;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 2;Y-box-binding protein 3 0 30891000.0 9833100.0 5564900.0 15493000.0 False True 9520953.622866813 7786993.59057012 11434918.519962769 1.0 0.8178795842328043 1.201026595959791 23.18267465105895 -6.7774643675803 1.5458924157478682 0.896538503882236 1.2038161675764434 0.7582633524123703 0.07693735198433925 0.2545363600536123 1.2013211847181358 0.03920738468967116 0.0927055068861935 1.669304762503667e-07 6.7774643675803 0.3072776636942074 SVGDGETVEFDVVEGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVGDGETVEFDVVEGEK 17 0 P67809;H0Y449;Q9Y2T7;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX2;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 2;Y-box-binding protein 3 0 51536000.0 0.0 51536000.0 0.0 False True 0.0 42338998.14739413 0.0 0.0 SVGDGETVEFDVVEGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVGDGETVEFDVVEGEK 17 0 P67809;H0Y449;Q9Y2T7;P16989;P16989-3;A0A0D9SEI8;P16989-2 P67809;P16989;P16989-2 YBX1;YBX2;YBX3 Nuclease-sensitive element-binding protein 1;Y-box-binding protein 2;Y-box-binding protein 3 0 16835400.0 9833100.0 3723400.0 3278900.0 False True 8176658.330190427 3703341.305162966 3964502.830079331 1.0 0.4529162349231631 0.4848561196988405 22.963079926493226 -9.983382143884617 5.463304633401454 1.0000014828409152 0.4688861773101018 0.9972949428384073 0.01303940336044749 2.355205016492597e-07 4.380236749284418e-08 0.012625383189752287 0.004208449337832683 1.0390055229768066e-10 9.983382143884617 -0.5311153055308133 SVGDGETVEFDVVEGEK(ub)GAEAANVTGPGGVPVQGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSK 36 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 54878000.0 17530000.0 11491000.0 25857000.0 True False 16973519.745436862 16079416.224773373 19084276.00662732 1.0 0.947323623263003 1.1243558373776843 24.01678242725089 -6.8269929060900845 1.3414862025146408 0.9717902380890331 1.1288271992597114 0.8996858321286727 0.023507762359076315 0.18455382053458017 0.6506207488469922 0.01376364412532023 0.031677557225227616 1.4893854056267581e-07 6.8269929060900845 0.15703696117067834 SVGDGETVEFDVVEGEK(ub)GAEAANVTGPGGVPVQGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSK 36 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 96643000.0 26681000.0 41696000.0 28266000.0 True False 40477027.64237811 34255023.0276651 22679212.710572075 1.0 0.8462830653059422 0.5602983724730739 25.270600016421493 -6.961434482738414 0.41472574687391306 1.0133822209793892 0.3825039690946813 0.9998197479825184 0.002446100077967136 0.07919267001690436 0.01926724937353558 0.0036888716491979673 0.023842340976148513 1.092862482971269e-07 6.961434482738414 -0.6308782518847079 SVGDGETVEFDVVEGEK(ub)GAEAANVTGPGGVPVQGSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSK 36 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 50494000.0 17530000.0 15727000.0 17237000.0 True False 14576971.710674983 15642275.529434927 20841177.00511675 1.0 1.0730812846388254 1.4297329664057985 23.797187702685168 -6.940348007858006 0.6563212963998376 0.9960194118778626 1.5269021849634978 0.9982090892361138 0.007944932570622964 0.0876082720199355 0.05389003342927097 0.007754328285840116 0.030649537741590096 1.1472339541927246e-07 6.940348007858006 0.5308827730856353 SVGDGETVEFDVVEGEK(ub)GAEAANVTGPGGVPVQGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVGDGETVEFDVVEGEKGAEAANVTGPGGVPVQGSK 36 1 P67809;H0Y449 P67809 YBX1 Nuclease-sensitive element-binding protein 1 1 93637000.0 26681000.0 48814000.0 18142000.0 True False 34539080.46113788 46097457.989045404 14840342.152639696 1.0 1.3346463592426145 0.4296681311286648 25.041726338513943 -6.8065820001605095 1.4287312647260497 1.183133058952947 0.415026405183162 0.8507389010865374 0.1443412571263592 0.21150271484774497 0.8515074176143886 0.07945087110127652 0.18409735252963239 1.5610542638223486e-07 6.8065820001605095 -0.7681066537697849 down SVGGSFYLQSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVGGSFYLQSK 11 0 P57737-3;A0A0A6YYL4;I3L3T0;I3L0X9;I3L1U7;Q9Y3D7 P57737-3 CORO7;CORO7-PAM16;PAM16 Coronin-7;Coronin;Mitochondrial import inner membrane translocase subunit TIM16 0 35119100.0 12888000.0 7791100.0 14440000.0 False True 16896292.807569534 6628698.249469936 12945887.318260802 1.0 0.392316724441487 0.7661969087361606 24.010203405699528 -10.594797426383172 6.504126958968563 1.0009739308118781 0.5792568165888854 0.6280491178766878 0.15263594607661454 0.0021601669156388866 0.0001345765968997875 0.14809963343773966 0.049263039765611825 2.5421582009179666e-11 10.594797426383172 -0.42171711422299274 SVGGSFYLQSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVGGSFYLQSK 11 0 P57737-3;A0A0A6YYL4;I3L3T0;I3L0X9;I3L1U7;Q9Y3D7 P57737-3 CORO7;CORO7-PAM16;PAM16 Coronin-7;Coronin;Mitochondrial import inner membrane translocase subunit TIM16 0 22559600.0 8184300.0 3355300.0 11020000.0 False True 7924493.876359319 4695088.787658351 8133531.407086418 1.0 0.5924780636987979 1.0263786601376157 22.917887365095623 -10.113918871971752 13.352066409762797 1.0000013623435453 0.8094283619182068 0.20458303814585221 0.17713917672914417 0.0 0.0 0.17151426780166962 0.05717142345247595 7.692741304948824e-11 10.113918871971752 -0.19057300042533853 SVGGSFYLQSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVGGSFYLQSK 11 0 P57737-3;A0A0A6YYL4;I3L3T0;I3L0X9;I3L1U7;Q9Y3D7 P57737-3 CORO7;CORO7-PAM16;PAM16 Coronin-7;Coronin;Mitochondrial import inner membrane translocase subunit TIM16 0 42573200.0 8946200.0 16637000.0 16990000.0 False True 13572039.454827156 13667997.364525694 13631919.053018466 1.0 1.0070702645698844 1.0044119823251776 23.694134193390212 -9.900118696365904 4.30151916722033 0.999999893380567 1.0057411234500149 0.861475961763048 0.0010852391976948323 1.1087278988481677e-09 2.857558666886283e-10 0.001050797853948178 0.0003502594433327341 1.2585813838150308e-10 9.900118696365904 0.0057412300694478224 SVGGSFYLQSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVGGSFYLQSK 11 0 P57737-3;A0A0A6YYL4;I3L3T0;I3L0X9;I3L1U7;Q9Y3D7 P57737-3 CORO7;CORO7-PAM16;PAM16 Coronin-7;Coronin;Mitochondrial import inner membrane translocase subunit TIM16 0 35900000.0 12888000.0 10446000.0 12566000.0 False True 17653041.885104198 9984461.179697402 9598169.604893625 1.0 0.5655943743113409 0.5437119374306051 24.07341346722242 SVGGSFYLQSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVGGSFYLQSK 11 0 P57737-3;A0A0A6YYL4;I3L3T0;I3L0X9;I3L1U7;Q9Y3D7 P57737-3 CORO7;CORO7-PAM16;PAM16 Coronin-7;Coronin;Mitochondrial import inner membrane translocase subunit TIM16 0 17773300.0 8184300.0 5310200.0 4278800.0 False True 6805608.075965613 5281592.8986078305 5173477.297064085 1.0 0.7760648041517513 0.7601785526460905 22.6982926405299 -13.999999999999998 0.37564242997358954 4.232124083594977 0.7586750976575152 0.9998003983019634 0.0015470205105338971 23.494838347074165 0.19946799558206094 61.29772851525792 0.004363273575342149 1.0000000000000041e-14 13.999999999999998 -3.4734489859374618 SVGGSFYLQSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVGGSFYLQSK 11 0 P57737-3;A0A0A6YYL4;I3L3T0;I3L0X9;I3L1U7;Q9Y3D7 P57737-3 CORO7;CORO7-PAM16;PAM16 Coronin-7;Coronin;Mitochondrial import inner membrane translocase subunit TIM16 0 49762200.0 8946200.0 22554000.0 18262000.0 False True 11581032.25596612 21298850.073440623 14938503.383943684 1.0 1.839114994474542 1.2899112146283782 23.46526051548266 -10.06661043762928 4.580061055137321 0.9999714039624866 1.564513104573341 0.5848389889651974 0.22421150431885423 35229799.546702154 38716153.98425125 8641.139876498602 0.07675356054981326 8.578069535062722e-11 10.06661043762928 0.5645417006108543 SVGGSGGGSFGDNLVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVGGSGGGSFGDNLVTR 17 0 P02545;P02545-3;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 0 30163200.0 5240100.0 15096000.0 9827100.0 False True 6869821.845200582 12843735.643747108 8810285.960199486 1.0 1.8695878777002115 1.2824620723395552 22.71184125550317 -10.418102905415275 7.870291955889925 0.9999848386025025 1.5760249750198831 0.5620548769124056 0.23969310632570673 6.376762392673619e-05 4.715122697470929e-06 0.23208794214188652 0.07736061741668217 3.8185378044866335e-11 10.418102905415275 0.5760401364173806 SVGGSGGGSFGDNLVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVGGSGGGSFGDNLVTR 17 0 P02545;P02545-3;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 0 23945600.0 7011100.0 3101500.0 13833000.0 False True 6788536.468182103 4339945.124108836 10209722.318895308 1.0 0.6393049730895866 1.5039651575488056 22.69466914855416 -6.793394753615641 1.482694998365953 0.7992949193341582 1.5140473553792784 0.8121551595203871 0.15369073491263863 0.23032437559508803 1.0001735946014338 0.08157382597890399 0.19052690498204689 1.6091822978763148e-07 6.793394753615641 0.7147524360451202 SVGGSGGGSFGDNLVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVGGSGGGSFGDNLVTR 17 0 P02545;P02545-3;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 0 31838100.0 5240100.0 12015000.0 14583000.0 False True 7177506.57837791 11484137.571708245 11138795.746312588 1.0 1.6000177006182024 1.5519032444871566 22.775051317026062 -10.086914810592189 4.526917946513647 0.9999594670763696 1.5759604725765626 0.9947933309408017 0.01964264457429946 13655263.831487957 0.4732937969628566 6029.044716678211 0.006724199684467821 8.186253505467148e-11 10.086914810592189 0.576001005500193 SVGGSGGGSFGDNLVTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVGGSGGGSFGDNLVTR 17 0 P02545;P02545-3;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 0 22726300.0 4897300.0 9281700.0 8547300.0 False True 6339651.390215158 8765165.235729966 6991779.102704083 1.0 1.3825941989899369 1.1028649167516436 22.59597207980944 -10.551711750811949 4.83360410071929 0.9983469927999317 1.2427295578708035 0.5009833195460232 0.1141990012665129 0.0020474355824244062 0.00018988750079983278 0.11128800839647054 0.03685756917155375 2.8072962736145916e-11 10.551711750811949 0.24438256507087186 SVGK(ub)IEHSFWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVGKIEHSFWR 11 1 Q16531;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 42053090.0 11645190.0 16715900.0 13692000.0 True False 15266956.862180382 14221952.878067851 12275283.182938138 1.0 0.9315512584763217 0.8040425668160969 23.863909184933746 -6.961410254679969 0.41508122382423135 1.005943631630751 0.7248788314112209 0.999818972844776 0.0010925198574702965 0.07920115040291624 0.019298015021041975 0.0016449814742669924 0.010629177885268444 1.0929234523728875e-07 6.961410254679969 -0.2810648002195302 SVGK(ub)IEHSFWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVGKIEHSFWR 11 1 Q16531;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 128404400.0 34163700.0 55284300.0 38956400.0 True False 51828830.60102379 45418384.72679252 31256650.46480329 1.0 0.8763150586286883 0.6030745842100066 25.627251507188706 -6.958053793213879 0.4620452486390212 1.0078038700509826 0.4605330513230716 0.9996910683453469 0.002914766794856031 0.08040379835482454 0.023756491386102672 0.0037239847144503687 0.02256754649623983 1.1014028775292449e-07 6.958053793213879 -0.547270818727911 SVGK(ub)IEHSFWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVGKIEHSFWR 11 1 Q16531;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 29824300.0 11645190.0 952110.0 17227000.0 True False 15950731.442426804 910042.6319932682 13158337.401201848 1.0 0.057053348009651575 0.8249363014289387 23.927119246456638 -10.752969233748551 8.855179535023096 1.0036300619968175 0.4409948247192957 0.414043357891686 0.3134869030097661 0.02248901065988508 0.0006273697247598966 0.3038383206386844 0.10117746288424698 1.7661629346135653e-11 10.752969233748551 -0.5626352372775218 SVGK(ub)IEHSFWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVGKIEHSFWR 11 1 Q16531;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 118762500.0 34163700.0 63543800.0 21055000.0 True False 44225583.11720621 60007531.67051057 17223206.04254375 1.0 1.3568511128836718 0.3894398858891013 25.398377829281156 -6.80683231287214 1.4276759740304559 1.195221463582213 0.37369297002670293 0.8514328257308555 0.15396394751873768 0.2111486500459005 0.8487843276838671 0.0848092546306923 0.19648960169417587 1.5601547839633553e-07 6.80683231287214 -0.82152849355551 down SVGYK(ub)PDFVGFEIPDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVGYKPDFVGFEIPDK 16 1 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 1 14668000.0 4443000.0 5821700.0 4403300.0 True False 5824816.026073202 4953125.052808864 3947688.7554361294 1.0 0.8503487544735404 0.6777362130864523 22.473781053002963 -6.969255535627975 0.27538867259624084 1.040201749344456 0.48265623644142064 0.9999759771296013 0.0006453541320677606 0.07654505258598188 0.009891680817881204 0.0032754801356894695 0.015938025848819194 1.0733576708703956e-07 6.969255535627975 -0.5575455129030353 SVGYK(ub)PDFVGFEIPDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVGYKPDFVGFEIPDK 16 1 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 1 36583400.0 9406400.0 12726000.0 14451000.0 True False 14270196.499953745 10454945.871308172 11594753.515901707 1.0 0.7326420397464086 0.8125153368378137 23.76650186500678 -10.174426130802997 7.359355520154517 1.0000001910467038 0.7725786882921113 0.9153210202314911 0.03260813699127838 1.0221463003015897e-07 1.1443153156419706e-08 0.03157271922550891 0.010524230959839271 6.692276393698475e-11 10.174426130802997 -0.2274215027545925 SVGYK(ub)PDFVGFEIPDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVGYKPDFVGFEIPDK 16 1 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 1 17900500.0 4443000.0 8446000.0 5011500.0 True False 6085697.167560361 8072827.792812952 3827886.9150823187 1.0 1.3265247301237622 0.6289972717483813 22.536991114525854 -6.779409677065603 1.538159620094249 1.1850275044338874 0.6235723009507492 0.7653026847475509 0.13804918648321704 0.25149075895293715 1.1752219108484288 0.07069153199306583 0.1668855951767314 1.6618442659540618e-07 6.779409677065603 -0.5614552034831382 SVGYK(ub)PDFVGFEIPDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVGYKPDFVGFEIPDK 16 1 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 1 24772900.0 10140000.0 10179000.0 4453900.0 True False 8431859.278165678 10124163.706626685 5385189.89749316 1.0 1.200703590113658 0.6386716997801569 23.00741935892897 -6.810147577075409 1.4139430956970334 1.1093613974311531 0.6288081786823284 0.860210423406707 0.08694721956545273 0.206595893398052 0.8140319424761624 0.04835213425390635 0.11183937480801714 1.5482904068470062e-07 6.810147577075409 -0.48055321874882473 SVGYK(ub)PDFVGFEIPDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVGYKPDFVGFEIPDK 16 1 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 1 29549100.0 9406400.0 7096700.0 13046000.0 True False 12176770.227864314 6701762.4064993365 10671761.86326412 1.0 0.55037274097228 0.8764033207133811 23.53762818709923 -9.969291928406568 6.713368436765922 1.0000000344962021 0.7133880308428285 0.5074890061640076 0.13310142681825374 6.867264780729569e-08 1.0727026604959083e-08 0.12887491867912504 0.04295830078529412 1.0732677299821922e-10 9.969291928406568 -0.2866120036533736 SVHFPGQAVGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVHFPGQAVGTR 12 0 Q06210-2;Q06210;A0A6I8PRN4;A0A6I8PTT9 Q06210-2 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 0 2591150.0 400200.0 1230600.0 960350.0 False True 524666.075542313 1046999.2768412288 860982.1943276837 1.0 1.9955536018962425 1.6410098431421216 19.00103998401134 -10.15692808195604 4.482835240313808 0.9998912844418277 1.8182817223721655 0.8765796826784921 0.14474188433471732 101320747.2621447 37.751442554237464 142233.90447412073 0.04954899676862993 6.967418832135282e-11 10.15692808195604 0.8183904379303377 SVHFPGQAVGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVHFPGQAVGTR 12 0 Q06210-2;Q06210;A0A6I8PRN4;A0A6I8PTT9 Q06210-2 GFPT1 Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 1 0 2012160.0 519500.0 536970.0 955690.0 False True 503008.75685992365 751384.921261558 705366.1189145572 1.0 1.4937809948919067 1.4022939149566045 18.940223990508205 -10.051612780389533 4.846848116536669 0.9999886596806775 1.448037454930292 0.9696765198372321 0.03734944400393374 4.577005093916235e-06 8.954968770523249e-07 0.03616435808210104 0.01205448121514864 8.879473584846451e-11 10.051612780389533 0.4480487952496144 SVHK(ub)VEPITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVHKVEPITK 10 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 17608700.0 2390800.0 4684900.0 10533000.0 True False 3134361.952540138 3985931.1815971723 9443146.199670427 1.0 1.2716882229784945 3.012781019759874 21.579740359531204 -6.934458514511916 0.7092486043686768 0.9773914014213757 3.4144903409877316 0.9973441235121977 0.045955045493155676 0.09038808099210724 0.06681939008746411 0.04303901510860761 0.15386036362973696 1.16289763017582e-07 6.934458514511916 2.437098939566356 up SVHK(ub)VEPITK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVHKVEPITK 10 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 85559800.0 2670000.0 8573800.0 74316000.0 True False 4050585.2031464158 7043738.402594845 59627410.026140116 1.0 1.7389433993694061 14.720690230098779 21.9496989239108 -6.918611893225757 0.8349565216074215 0.6989851617677953 16.748708325462136 0.9937865772961378 0.49668198181844975 0.09899547265105826 0.1098970157885781 0.424826172952055 1.2561509558014186 1.2061133007008922e-07 6.918611893225757 16.049723163694342 up SVHK(ub)VEPITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVHKVEPITK 10 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 28860000.0 2670000.0 5365000.0 20825000.0 True False 3456367.633568387 5066433.033785978 17035063.682544462 1.0 1.465825852719071 4.9286029405839855 21.720825246003248 -6.931488946010953 0.734467664462352 0.9501427647887244 5.667220190120234 0.9968228685798766 0.09878227472758094 0.09187204615200846 0.07394653007994595 0.09080591248445136 0.3107959691937733 1.1708764039658297e-07 6.931488946010953 4.717077425331509 up SVHKVEPITK(ub)HIGLVYSGMGPDYR ddPTM_RPMI8226_Bortezomib_8h_R1 2 SVHKVEPITKHIGLVYSGMGPDYR 24 2 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 118216100.0 33881000.0 14805600.0 69529500.0 True False 51399954.03288531 12163425.003319204 55786963.849137515 1.0 0.23664272142222412 1.0853504618592738 25.61526373342528 -6.6696583557165505 1.9382351498551829 0.512624539829205 1.0819429293788139 0.27771072658181495 0.3242801303335122 0.4618851508495219 3.344854264727659 0.1346961895022101 0.3600805932966153 2.139644611226177e-07 6.6696583557165505 0.5693183895496089 SVHKVEPITK(ub)HIGLVYSGMGPDYR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SVHKVEPITKHIGLVYSGMGPDYR 24 2 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 87135800.0 33881000.0 22716800.0 30538000.0 True False 43859622.39435602 21452590.11032793 24980397.346340604 1.0 0.48911935258905714 0.5695534065873571 25.38639005551773 -10.731037171994778 6.9103846093610715 1.0065173946849597 0.52933637958836 0.9785656702767653 0.032837065039884 0.0033072488057102763 0.0001287230970875452 0.0318914578841605 0.010598117169816715 1.8576454492902035e-11 10.731037171994778 -0.4771810150965997 SVHSQDPSGDSK(ub)LYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVHSQDPSGDSKLYR 15 1 Q86T24 Q86T24 ZBTB33 Transcriptional regulator Kaiso 1 22880260.0 2101260.0 2941900.0 17837100.0 True False 3187765.0426829383 2416894.9598303894 14311589.36672133 1.0 0.7581785129923638 4.489537081652724 21.60411386733262 -6.8914255133237186 1.0138896067328431 0.8063080090014155 4.819604396403154 0.9817958876181634 0.23002177472824212 0.11799502527018975 0.21514197982066044 0.17252922039797958 0.43239461341525026 1.2840279776793565e-07 6.8914255133237186 4.013296387401739 up SVHSQDPSGDSK(ub)LYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVHSQDPSGDSKLYR 15 1 Q86T24 Q86T24 ZBTB33 Transcriptional regulator Kaiso 1 92564060.0 2101260.0 1228000.0 89234800.0 True False 2720122.4920269344 1159660.720501245 72994982.02636832 1.0 0.42632665400193387 26.83518195975622 21.37524018942507 -6.9014664661133365 0.9520797480992992 1.0886445716239753e-15 29.689925822603918 0.9875465057267812 1.3744363225177116 0.10958264523021584 0.17028853503673677 1.0828860831176954 2.8383775836833953 1.2546816138913254e-07 6.9014664661133365 29.689925822603918 up SVHYCPATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVHYCPATK 9 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 13672400.0 2155600.0 6507300.0 5009500.0 False True 2826012.4748600917 5536436.205256731 4491164.994517135 1.0 1.9590982893770932 1.5892233436582692 21.430336403495343 -10.190304198511436 4.5820462956511685 0.9998786670016175 1.7741608164231462 0.853823709169454 0.15100081527051795 0.00023284916916889366 4.1147170700799325e-05 0.14623403035471264 0.04873530341756449 6.452021434253651e-11 10.190304198511436 0.7742821494215286 SVHYCPATK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVHYCPATK 9 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 4192150.0 2311800.0 833850.0 1046500.0 False True 1922364.1301048743 829357.8845437344 1265318.311530702 1.0 0.4314260090248817 0.6582094888868285 20.874450203531612 -10.244871730663844 5.558472128695615 1.000028895211692 0.5448177489558418 0.8430483336555529 0.09258396795914751 3.315476311559825e-05 4.504128473734749e-06 0.08964971974631084 0.02988134716928932 5.690209669743051e-11 10.244871730663844 -0.45521114625585024 SVILEAFSSPSEEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVILEAFSSPSEEVK 15 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 8414400.0 1774200.0 3054400.0 3585800.0 False True 2325993.3813772392 2598695.42595795 3214775.8134224075 1.0 1.117241109439117 1.382108753688247 21.149415560947077 -6.9575938442709955 0.46811413217974107 0.9928743686320904 1.5172993446724519 0.9996702825455935 0.0029021868777620538 0.08057212115781286 0.024394063510512994 0.0036493833076802545 0.021864073083236468 1.1025699599171373e-07 6.9575938442709955 0.5244249760403614 SVILEAFSSPSEEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVILEAFSSPSEEVK 15 0 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 8046400.0 1774200.0 2741900.0 3530300.0 False True 2430169.6859521926 2620753.7917492148 2696515.8488107603 1.0 1.0784241968364225 1.1095998211146345 21.212625622469968 -13.999999999999998 0.12731139271838973 0.6273315418208023 1.1547873925604002 0.9996579369773365 0.0008527647251855154 11.94191095650827 0.11068594205358474 1.1164859122843875 0.04015170524175132 1.0000000000000041e-14 13.999999999999998 0.5274558507395979 SVILIFSVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVILIFSVR 9 0 J3QR07;Q96MU7-2;Q96MU7 J3QR07 YTHDC1 YTH domain-containing protein 1 0 24284400.0 4910600.0 10555000.0 8818800.0 False True 7449739.212947868 8671377.783408592 7075760.314582651 1.0 1.1639840718635466 0.9497997328933031 22.82875849251346 -6.702140887985019 1.823353109724043 1.1016151811540231 0.9504136226208495 0.42765601775126194 0.0691932554511531 0.3911040006872084 2.5294004096103677 0.030258261172642926 0.07760785708640147 1.9854507196060636e-07 6.702140887985019 -0.15120155853317363 SVILIFSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVILIFSVR 9 0 J3QR07;Q96MU7-2;Q96MU7 J3QR07 YTHDC1 YTH domain-containing protein 1 0 19070900.0 4910600.0 7136200.0 7024100.0 False True 6356868.502397355 6739064.19677605 5745785.8733522445 1.0 1.0601232657612092 0.9038704939681144 22.59988481460591 -6.8024096367984885 1.446176512241353 1.033072533897177 0.9015863338361502 0.8390661079734021 0.0258158119384766 0.21734700271957866 0.8971750856657493 0.014042054631267583 0.03260810273969037 1.5761239310973314e-07 6.8024096367984885 -0.13148620006102674 SVLDAAQIVGLNCLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVLDAAQIVGLNCLR 15 0 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 19370600.0 3612400.0 11115000.0 4643200.0 False True 4735891.382531357 9456685.325930653 4162766.204719424 1.0 1.996812123017063 0.8789826177336029 22.175204562520697 -6.67149741256308 1.9318047512162415 1.6354251540649967 0.8834412084565857 0.28583394583708743 0.42327560333173514 0.45767165797981596 3.2941492474537957 0.17629469198943046 0.47014202867655114 2.1306032611995577e-07 6.67149741256308 -0.751983945608411 SVLDAAQIVGLNCLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVLDAAQIVGLNCLR 15 0 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 45743100.0 5451500.0 31591000.0 8700600.0 False True 8270324.058034716 25953339.228390437 6980922.596391553 1.0 3.138128451348465 0.844092994108194 22.97951242928422 -6.66191761107443 1.9655605292979679 2.374017853275941 0.853477632578394 0.2441265558611817 0.9099314720113838 0.4798260280634788 3.5654302403671703 0.3737097529453352 1.0092714383750407 2.1781229394448043e-07 6.66191761107443 -1.520540220697547 SVLDAAQIVGLNCLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVLDAAQIVGLNCLR 15 0 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 31538500.0 3612400.0 8631100.0 19295000.0 False True 4948001.90143935 8249749.462769114 14737918.392998777 1.0 1.6672890647777039 2.9785595653695256 22.23841462404359 -6.9603879349508775 0.4299310284570874 0.9478762168254568 3.7482518166915675 0.9997843189075928 0.012070220356015352 0.07956282790043898 0.020621377140703147 0.017097514743155517 0.10887778232031844 1.0954992007579294e-07 6.9603879349508775 2.800375599866111 SVLDAAQIVGLNCLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVLDAAQIVGLNCLR 15 0 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 19958200.0 5451500.0 7453500.0 7053200.0 False True 7057074.215130363 7038706.172846934 5769589.971943468 1.0 0.997397215655739 0.8175611869822016 22.75063875137667 -6.910050984349484 0.8953878529131896 1.0055591020261896 0.7942950613929479 0.990940785544267 0.00812794409816786 0.10438429848832582 0.13858458551885916 0.00665613556421331 0.01838043584320769 1.2301243508993182e-07 6.910050984349484 -0.21126404063324167 SVLDLSLQWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVLDLSLQWR 10 0 Q9BZE9;Q9BZE9-2;J3QL04;J3QR50;J3QRW3;J3KRG1 Q9BZE9 ASPSCR1 Tether containing UBX domain for GLUT4 0 30129200.0 6422200.0 12785000.0 10922000.0 False True 9742946.925710473 10503416.860339066 8763261.91271735 1.0 1.0780533795808538 0.8994467464040216 23.215926776135976 -6.787905564851831 1.5045201847508547 1.04374285399666 0.8976507028634318 0.7945235713478496 0.033139702676951155 0.23848567193960757 1.0664585434827587 0.0173391858165326 0.0406610482285697 1.6296503533788163e-07 6.787905564851831 -0.14609215113322815 SVLDLSLQWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVLDLSLQWR 10 0 Q9BZE9;Q9BZE9-2;J3QL04;J3QR50;J3QRW3;J3KRG1 Q9BZE9 ASPSCR1 Tether containing UBX domain for GLUT4 0 20906600.0 6422200.0 7163500.0 7320900.0 False True 8313664.500487993 6764844.927777411 5988571.318777424 1.0 0.8137019394251874 0.7203287212787945 22.987053098228426 -13.999999999956927 0.08955902783524364 1.9557763211571948 0.48484718267612187 0.9998444719065103 0.001449842072290479 12.167697788302066 0.08684381865467655 2.2174593891855237 0.2116596081964389 1.0000000000991795e-14 13.999999999956927 -1.470929138481073 SVLEQTK(ub)LK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVLEQTKLK 9 1 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 1 3127720.0 671850.0 1911200.0 544670.0 True False 880801.8562046542 1626056.4097992524 488312.7732435672 1.0 1.8461091996398318 0.5543957131830882 19.74845798368245 -6.7299840592514535 1.7232732311234953 1.5091948786252554 0.5551650531519331 0.5591907715302709 0.35568475590870186 0.336272087591448 1.9563754348095985 0.16356433151781527 0.4058834241976891 1.8621554856951905e-07 6.7299840592514535 -0.9540298254733223 SVLEQTK(ub)LK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVLEQTKLK 9 1 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 1 10118100.0 2052100.0 2795400.0 5270600.0 True False 3113185.7286055298 2296539.02944011 4228863.599813957 1.0 0.7376813430494508 1.35837176720843 21.569960218005736 -6.79193317260519 1.4890464850917629 0.8537567573821065 1.3652871947896503 0.8073863297774831 0.11165277435854122 0.23248757117578192 1.018374440513686 0.05901923688948712 0.13795977343637897 1.614606986594494e-07 6.79193317260519 0.5115304374075438 SVLEQTK(ub)LK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVLEQTKLK 9 1 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 1 2497770.0 671850.0 1022700.0 803220.0 True False 920251.1010635666 977513.7323833558 613515.9788351639 1.0 1.0622250071242607 0.6666832325721771 19.81166804520534 -6.866680081605084 1.1515744730649307 1.0345731856365612 0.6449401140369546 0.961252645943191 0.034184162134808994 0.14007450351921458 0.3492700260403901 0.023081924890057615 0.054351513353688014 1.3593144023168642e-07 6.866680081605084 -0.3896330715996066 SVLEQTK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVLEQTKLK 9 1 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 1 4206140.0 948220.0 2405100.0 852820.0 True False 788486.9432684666 2392143.248925028 1031140.7190058401 1.0 3.0338400265818266 1.3077460924482982 19.588727339740746 -6.606105929641677 2.1684483079814263 2.362358039607727 1.3137429223234955 0.03841160664459031 0.8777269851044701 0.6234189011786518 5.549263324592382 0.33495508675314445 0.9749228143459252 2.4768178583188294e-07 6.606105929641677 -1.0486151172842313 SVLEQTK(ub)LK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVLEQTKLK 9 1 P34932;A0A087WYC1;A0A087WTS8 P34932 HSPA4 Heat shock 70 kDa protein 4 1 10266400.0 2052100.0 1842600.0 6371700.0 True False 2656483.902938461 1740057.6902244226 5212115.979162953 1.0 0.6550228624760961 1.9620355965257639 21.341086540098186 -6.836526381052406 1.2983594442006015 0.8163176770161731 2.002170249987809 0.9183298735061834 0.15805127533973595 0.17289230221456459 0.5676295344933746 0.09550307778594523 0.21986650184377873 1.4570471942669468e-07 6.836526381052406 1.185852572971636 SVLFVCLGNICR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVLFVCLGNICR 12 0 G5E9R5;P24666-4;P24666;F2Z2Q9;D3YTI2;P24666-3;P24666-2 G5E9R5 ACP1 Low molecular weight phosphotyrosine protein phosphatase 0 77379000.0 25742000.0 31903000.0 19734000.0 False True 33748011.28588263 27143196.756919984 17692114.981894646 1.0 0.8042902595648487 0.5242417051488767 25.00829915326303 -6.966028691197807 0.3399347462865827 1.0303982500861069 0.2888278472919079 0.9999328062323082 0.0016004246706750583 0.07761359547395696 0.013638588323590693 0.003954059789814431 0.024240560419484344 1.0813625098870435e-07 6.966028691197807 -0.741570402794199 SVLFVCLGNICR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVLFVCLGNICR 12 0 G5E9R5;P24666-4;P24666;F2Z2Q9;D3YTI2;P24666-3;P24666-2 G5E9R5 ACP1 Low molecular weight phosphotyrosine protein phosphatase 0 123800000.0 111500000.0 12300000.0 0.0 False True 107960493.53201441 17211454.14365264 0.0 1.0 0.15942363341038995 0.0 26.685928236186385 -9.896624742549202 0.43598789388269865 1.330163069811238 1.2044018311235206e-24 0.9985268060953996 0.016837619066731088 1.341995083130047 0.21607063764182238 0.6376917172749041 0.037780242368074646 1.2687476692864023e-10 9.896624742549202 -1.330163069811238 SVLFVCLGNICR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVLFVCLGNICR 12 0 G5E9R5;P24666-4;P24666;F2Z2Q9;D3YTI2;P24666-3;P24666-2 G5E9R5 ACP1 Low molecular weight phosphotyrosine protein phosphatase 0 1374770000.0 378610000.0 526220000.0 469940000.0 False True 574379050.0986011 432311929.6243743 377056153.01798123 1.0 0.7526596409638568 0.6564587495892367 29.097427888360752 -13.999999999999998 0.13063071368041543 2.175534278859898 0.5228089625294716 0.9996427692566094 0.002734973305961881 11.9358092101637 0.1124576902246723 3.6005411196923247 0.11888741570460257 1.0000000000000041e-14 13.999999999999998 -1.6527253163304265 SVLFVCLGNICR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVLFVCLGNICR 12 0 G5E9R5;P24666-4;P24666;F2Z2Q9;D3YTI2;P24666-3;P24666-2 G5E9R5 ACP1 Low molecular weight phosphotyrosine protein phosphatase 0 287262000.0 25742000.0 111480000.0 150040000.0 False True 35259513.05139297 106554444.98493828 114603642.17079751 1.0 3.022005574201448 3.2502899856772114 25.071509214785923 -10.25547662322103 0.47159596841102863 1.005778832970577e-18 3.2498232466271975 0.9993584896566032 0.025614088478253506 1.5948308746647446 0.21934973720330364 2.130558627363585 0.04893584154992197 5.5529450616516904e-11 10.25547662322103 3.2498232466271975 SVLFVCLGNICR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVLFVCLGNICR 12 0 G5E9R5;P24666-4;P24666;F2Z2Q9;D3YTI2;P24666-3;P24666-2 G5E9R5 ACP1 Low molecular weight phosphotyrosine protein phosphatase 0 1064330000.0 378610000.0 373050000.0 312670000.0 False True 490118108.5188492 352289439.56269443 255767268.26512256 1.0 0.7187847856250876 0.5218482317212447 28.8685542104532 -7.802729073149851 0.1245230876171997 1.3996857049156144 8.881087452183387e-13 0.9999842447436637 0.000778803882426381 0.1300724092274451 0.016783291996655996 0.07616167491273637 0.10009439303875749 1.5749650718779635e-08 7.802729073149851 -1.3996857049147262 SVLGEADQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVLGEADQK 9 0 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 9125610.0 2130000.0 891310.0 6104300.0 False True 2062384.315903051 1247214.7311202476 4505400.704925367 1.0 0.6047440923124616 2.18455923572741 20.97588176671719 -6.840443844260091 1.2803302984829992 0.7897473458586636 2.236981085324836 0.9252202357880485 0.18356006345182255 0.16827604147860167 0.5356411260628122 0.1124125646914931 0.25900853699713106 1.4439633015406536e-07 6.840443844260091 1.4472337394661725 up SVLGEADQK(ub)GSLVAPDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVLGEADQKGSLVAPDR 17 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 19424500.0 4979100.0 6702600.0 7742800.0 True False 6527648.317672985 5702598.206530167 6941649.330182119 1.0 0.8736068380232628 1.063422689514119 22.638131902366364 -6.727205478984718 1.7333865058923281 0.9237022637136568 1.0632543044970977 0.5463000385300829 0.0531452696261189 0.3414906283676676 2.0088055180835633 0.024309604279977144 0.06051517632483383 1.8741075964075171e-07 6.727205478984718 0.13955204078344086 SVLGEADQK(ub)GSLVAPDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVLGEADQKGSLVAPDR 17 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 29297400.0 4999900.0 9190500.0 15107000.0 True False 4841180.911306891 12860314.57782436 11150023.49971454 1.0 2.6564416437708958 2.3031619152411635 22.20692757696408 -10.042591975733828 5.840356149065683 0.9999962103447513 2.47980177950623 0.9590066664997794 0.14422584522851148 7.116745221522374e-06 1.1668715196546935e-06 0.13964643170674687 0.04654869138845567 9.065839461323605e-11 10.042591975733828 1.4798055691614787 SVLGEADQK(ub)GSLVAPDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVLGEADQKGSLVAPDR 17 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 83531100.0 9408100.0 18540000.0 55583000.0 True False 14272775.524240388 15231392.146318829 44596995.68710566 1.0 1.067163994869138 3.1246197077340474 23.766762576859467 -6.9138453516782805 0.869129782792378 0.9437801710172529 3.4136073605936823 0.9922937794860393 0.08656538798422125 0.1019299889081226 0.12537735791334284 0.07224828201291454 0.20517651905929113 1.2194237473464883e-07 6.9138453516782805 2.4698271895764297 up SVLGEADQK(ub)GSLVAPDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVLGEADQKGSLVAPDR 17 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 22534200.0 4979100.0 7837600.0 9717500.0 True False 6820007.825118115 7491308.916522711 7422426.6381946495 1.0 1.0984311321362699 1.0883311029142553 22.701341963889256 -10.112566480923228 4.177374658549537 0.9999819060638833 1.0933811175425927 0.991302479787431 0.004123319722791437 2873757.943045516 0.033667570317516174 506.62126357697275 0.0014115220062681758 7.716733803388537e-11 10.112566480923228 0.09339921147870944 SVLGEADQK(ub)GSLVAPDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVLGEADQKGSLVAPDR 17 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 18665800.0 4999900.0 6254000.0 7411900.0 True False 4157638.38312629 6220308.460678197 8961694.021246439 1.0 1.4961157963913412 2.15547702696255 21.987332852398357 -6.967189935497818 0.3182331615612441 0.90780784181071 2.7649971998173957 0.9999514321373626 0.0032983708604422076 0.07722547749079176 0.012279642683412511 0.010067173918167053 0.05809039163424437 1.0784749559848051e-07 6.967189935497818 1.8571893580066856 SVLGEADQK(ub)GSLVAPDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVLGEADQKGSLVAPDR 17 1 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 67177100.0 9408100.0 17878000.0 39891000.0 True False 12178970.91137632 16883073.583974946 32631247.316224817 1.0 1.3862479602611208 2.6793107195735333 23.537888898951916 -6.9489624336661935 0.5701194432292478 0.9839011103367952 3.144538378175012 0.9991173344454992 0.02133515768109801 0.08390505120256904 0.037707207751235663 0.0226002136604705 0.1077407190545181 1.1247022561449279e-07 6.9489624336661935 2.160637267838217 up SVLHEVMEQQTLSIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVLHEVMEQQTLSIAK 16 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 14445900.0 3774500.0 6210300.0 4461100.0 False True 4948406.05231 5283747.447559798 3999508.1658928813 1.0 1.0677675582207435 0.8082417092723915 22.238532458001103 -6.837327004404862 1.2946329019923577 1.0360739536002628 0.8001415237527126 0.9197771783504622 0.031129857632499588 0.17194569791766673 0.5609520914045795 0.018861909546306236 0.0434308519106277 1.4543635971856842e-07 6.837327004404862 -0.23593242984755014 SVLHEVMEQQTLSIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVLHEVMEQQTLSIAK 16 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 15112500.0 5048000.0 2492300.0 7572200.0 False True 4887754.0031355 3487488.387172799 5588813.658869302 1.0 0.7135155298191299 1.1434318616043426 22.22074024658654 -6.727036170432192 1.7336001562933978 0.8270359241559744 1.1430624784845234 0.5457015897576623 0.1204616249525366 0.3418049169569011 2.010989828508822 0.055091647570543766 0.1371900918149475 1.874838354718864e-07 6.727036170432192 0.316026554328549 SVLHEVMEQQTLSIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVLHEVMEQQTLSIAK 16 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 15675400.0 3774500.0 5639000.0 6261900.0 False True 5170034.652027148 5389850.334320653 4782968.18787867 1.0 1.042517255122713 0.9251327137630092 22.301742519523994 -6.80869839072152 1.4198433526341685 1.023207500843578 0.9231366546572393 0.8564429738128555 0.018385544516113062 0.20857852517607847 0.8289577602745154 0.010182238858247022 0.023569493862512978 1.553465487733277e-07 6.80869839072152 -0.10007084618633866 SVLHEVMEQQTLSIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVLHEVMEQQTLSIAK 16 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3IRR8 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 10586600.0 5048000.0 2676800.0 2861800.0 False True 4197635.664317588 2662379.5470967996 3460189.148531833 1.0 0.6342569389069701 0.8243185986686526 22.001145522020817 -10.105502564430257 4.80768498036359 1.0000135533272416 0.7292877687853911 0.7300936439602017 0.07759234768876544 19947791.256303206 41929215.33162371 1822.4576065053286 0.026561926195752494 7.843274875565308e-11 10.105502564430257 -0.2707257845418505 SVLHEVMEQQTLSIAK(ub)AGIICQLNAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVLHEVMEQQTLSIAKAGIICQLNAR 26 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 46409200.0 9258200.0 17423000.0 19728000.0 True False 14045366.265082475 14313729.523479661 15828752.152910434 1.0 1.019106889299452 1.1269732561023738 23.743590910742657 -6.937136866605826 0.6856751752532485 0.9987085523594911 1.153765201877782 0.9977644270704433 0.002643008660041643 0.08909724373456576 0.06074025091289693 0.0025200585177041976 0.009406904344475957 1.1557479542851578e-07 6.937136866605826 0.1550566495182909 SVLHEVMEQQTLSIAK(ub)AGIICQLNAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVLHEVMEQQTLSIAKAGIICQLNAR 26 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 28416900.0 9258200.0 12047000.0 7111700.0 True False 11984922.406405577 11376573.859835908 5817443.572204151 1.0 0.9492405102060131 0.4853968490521811 23.514717232835107 -6.927710941029878 0.7653622356141262 1.0076854650720757 0.39549940127873673 0.9960685589063669 0.01451854180072491 0.09384452714033166 0.08363606386722464 0.013051126346181255 0.042510597390803824 1.181106498353902e-07 6.927710941029878 -0.612186063793339 down SVLISLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVLISLK 7 0 P09496-2;P09496-4;P09496-3;P09496;P09496-5;C9J8P9 P09496-2 CLTA Clathrin light chain A 0 50202000.0 15330000.0 15252000.0 19620000.0 False True 20097778.455931168 12976461.051830351 17589910.608329415 1.0 0.6456664392178527 0.8752166637172955 24.2605327035391 -10.55893192171359 6.417773613129815 1.0003537825576796 0.7604415514675741 0.592191710720663 0.09371348672749347 0.0004750657637926773 3.264940460887621e-05 0.09086921140864769 0.030245897784217664 2.7610106274126125e-11 10.55893192171359 -0.2399122310901055 SVLISLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVLISLK 7 0 P09496-2;P09496-4;P09496-3;P09496;P09496-5;C9J8P9 P09496-2 CLTA Clathrin light chain A 0 53623000.0 23678000.0 8327000.0 21618000.0 False True 22926354.8506819 11652014.524731342 15955597.273901457 1.0 0.5082366822209757 0.6959500268498587 24.450503657731034 -10.111561028067023 5.18328993275297 1.000009879714923 0.6020933545348887 0.8569621940605066 0.07663365204383998 8.749510587425684e-06 1.4996733200493528e-06 0.07420205664934512 0.02473340484347185 7.734619824678074e-11 10.111561028067023 -0.3979165251800344 SVLISLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVLISLK 7 0 P09496-2;P09496-4;P09496-3;P09496;P09496-5;C9J8P9 P09496-2 CLTA Clathrin light chain A 0 83732000.0 24456000.0 32799000.0 26477000.0 False True 37101539.973089464 26945762.190243334 21243809.344718654 1.0 0.7262707211018106 0.5725856490088347 25.144975734222854 -13.85618784070092 0.06895834595100823 2.573446232468446 3.276160976830602e-11 0.9999317746921554 0.0014600872463757877 11.713801984863556 0.06872230568299804 3.0287391859964368 0.5174694808519855 1.392554366174613e-14 13.85618784070092 -2.573446232435684 SVLISLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVLISLK 7 0 P09496-2;P09496-4;P09496-3;P09496;P09496-5;C9J8P9 P09496-2 CLTA Clathrin light chain A 0 59791000.0 15330000.0 20346000.0 24115000.0 False True 20997915.277672816 19447046.444775324 18419533.664014786 1.0 0.9261417711049373 0.8772077332648525 24.32374276506199 SVLISLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVLISLK 7 0 P09496-2;P09496-4;P09496-3;P09496;P09496-5;C9J8P9 P09496-2 CLTA Clathrin light chain A 0 42456700.0 23678000.0 10904000.0 7874700.0 False True 19689306.113255102 10845257.987725466 9521263.361501016 1.0 0.5508197152983616 0.4835753635366142 24.23090893316531 -13.999999999999998 0.26740557746075816 4.419148549981541 0.4606872305110118 0.9995777803434955 0.004710517647041011 14.75738112419935 0.1636756504713492 27.387489647235764 0.028294756471181237 1.0000000000000041e-14 13.999999999999998 -3.9584613194705294 SVLISLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVLISLK 7 0 P09496-2;P09496-4;P09496-3;P09496;P09496-5;C9J8P9 P09496-2 CLTA Clathrin light chain A 0 88879000.0 24456000.0 40966000.0 23457000.0 False True 31658774.099830925 38686206.08799186 19188066.689145036 1.0 1.221974229513785 0.6060900093174332 24.916102056315303 -6.809223431305996 1.4178883987681177 1.121083668549489 0.5955141728348483 0.8577740579247758 0.09604659596247857 0.207857068491588 0.8237612821245133 0.053267223254849325 0.12325662713758935 1.5515885594494376e-07 6.809223431305996 -0.5255694957146406 SVLISLK(ub)QAPLVH ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVLISLKQAPLVH 13 1 P09496-2;P09496-4;P09496-3;P09496;P09496-5;C9J8P9 P09496-2 CLTA Clathrin light chain A 1 5113200.0 2120800.0 1962500.0 1029900.0 True False 2053476.3648672265 2746136.4843023033 760138.2936622777 1.0 1.3373109772704215 0.37017143545814646 20.969636911583887 -6.812474982195457 1.4039668465254778 1.1833014222012308 0.3522537360537768 0.866227708890878 0.14659500861958105 0.20344177132270472 0.7898493026018535 0.08208848973598175 0.18969591103200892 1.5400152370427322e-07 6.812474982195457 -0.8310476861474541 down SVLK(ub)SVESTSPEPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVLKSVESTSPEPSK 15 1 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;P18583-6;P18583-8;P18583-3 P18583-2;P18583-3 SON Protein SON 1 2894560.0 1015300.0 933970.0 945290.0 True False 1390683.8474508293 892704.1171742281 722031.9708586585 1.0 0.6419173695089542 0.5191920307280247 20.40736304991156 -13.999999999668276 0.1494365910152755 2.729994009154499 0.3832912345671737 0.9995681308737085 0.0042389442790616225 11.955657346697738 0.12171655735276675 6.006838641860911 0.12242717000663121 1.0000000007638226e-14 13.999999999668276 -2.3467027745873255 SVLLLAYK(ub)PMEGNFEEIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVLLLAYKPMEGNFEEIAR 19 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 31905300.0 3914300.0 5799000.0 22192000.0 True False 3790042.6890794896 8114570.941385495 16379249.454270562 1.0 2.141023626136604 4.321653025562276 21.853782667582397 -6.96092414026981 0.4222080556203473 0.9058728709419279 5.639361221305248 0.9998029521185756 0.01934378540357288 0.07937263938102258 0.019923696378363567 0.028250233975050047 0.18141181958867475 1.0941474681315458e-07 6.96092414026981 4.73348835036332 SVLLLAYK(ub)PMEGNFEEIAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVLLLAYKPMEGNFEEIAR 19 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 123642000.0 14185000.0 50270000.0 59187000.0 True False 21519682.062409 41298925.73869732 47488663.50741637 1.0 1.9191234154355417 2.2067548846537326 24.359153427497606 -10.477120623010514 0.250092333027649 5.456523654897854e-12 2.35594635830832 0.9991562311635425 0.014949383123827199 2.1081055856581936 0.12352194124079482 1.4600994915241896 0.1304804833234262 3.333338181883757e-11 10.477120623010514 2.3559463583028637 SVLLLAYK(ub)PMEGNFEEIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVLLLAYKPMEGNFEEIAR 19 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 21739200.0 3914300.0 5793900.0 12031000.0 True False 3254913.8828919013 5762687.1107008895 14546626.47494109 1.0 1.7704576274629118 4.469127908851712 21.634187943016673 -6.947926505330658 0.5811616913352387 0.9678800939083206 5.405452674081119 0.9990283597727645 0.04636401282356518 0.08432919070744886 0.0394916611964254 0.048516531638785027 0.2255072676379145 1.127388225383592e-07 6.947926505330658 4.437572580172799 SVLLLAYK(ub)PMEGNFEEIAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVLLLAYKPMEGNFEEIAR 19 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 58822000.0 14185000.0 44637000.0 0.0 True False 18362762.128152687 42152911.71092345 0.0 1.0 2.295564872906409 0.0 24.130279749590056 -6.75625603879279 1.6442534237534054 1.7583774919287964 5.68233066301745e-10 0.6641280205369353 0.5446248696692766 0.2917176267584095 1.556475679409826 0.2622647609653274 0.6282234979823347 1.7528468043881463e-07 6.75625603879279 -1.7583774913605634 SVLLLAYKPMEGNFEEIAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVLLLAYKPMEGNFEEIAR 19 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 0 37594600.0 4887600.0 19415000.0 13292000.0 False True 7414846.531422632 15950241.559912639 10664830.37390943 1.0 2.1511222777597236 1.4383076343811054 22.82198540217309 -10.111276689830715 4.743649362357209 0.9999618697686755 1.794714956078948 0.6236820349380658 0.29100535966810254 0.00014881819237076084 2.7880610752300206e-05 0.28178179059129294 0.09392157595751499 7.739685438786547e-11 10.111276689830715 0.7947530863102724 SVLLLAYKPMEGNFEEIAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVLLLAYKPMEGNFEEIAR 19 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 0 22488700.0 4887600.0 10959000.0 6642100.0 False True 6327094.54899957 10349122.016264776 5433305.953701251 1.0 1.635683161697206 0.8587363301786531 22.59311172426554 -6.689167428482335 1.868901644853049 1.398822235434458 0.8614096559696557 0.3668128272661566 0.2688913904787303 0.4184218134682521 2.832742876577591 0.1151153650669569 0.3001356322849067 2.045655846867107e-07 6.689167428482335 -0.5374125794648023 SVLQNTFPHANIWDILGIHSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVLQNTFPHANIWDILGIHSK 21 0 Q9NYU1 Q9NYU1 UGGT2 UDP-glucose:glycoprotein glucosyltransferase 2 0 7646600.0 4398700.0 1030500.0 2217400.0 False True 4259065.676226645 1441984.023986507 1636596.4194258985 1.0 0.33856815874791696 0.3842618414083379 22.022105546227202 -9.914792249316513 6.766315025438838 1.0000000289975433 0.36141500007811944 0.9961746455213248 0.018654367831143964 8.157314026155908e-09 1.3524244933427379e-09 0.018062014793430364 0.006020671328666397 1.2167679189657525e-10 9.914792249316513 -0.6385850289194238 SVLQNTFPHANIWDILGIHSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVLQNTFPHANIWDILGIHSK 21 0 Q9NYU1 Q9NYU1 UGGT2 UDP-glucose:glycoprotein glucosyltransferase 2 0 9694400.0 4398700.0 2345400.0 2950300.0 False True 3657713.945450428 2332764.8646745477 3567194.08935406 1.0 0.6377658011163254 0.9752523413677663 21.80251082166148 -10.494377166353948 8.749016501043352 1.0000072938711944 0.8065090719232987 0.30472283820875345 0.13777830311221442 1.9602654031590045e-05 1.1329542079138315e-06 0.13340829492401654 0.044467756118527005 3.203486024229536e-11 10.494377166353948 -0.19349822194789568 SVLWWLPVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVLWWLPVEK 10 0 J3KQJ1;Q8NBJ7;C9J660;C9JL30;Q8NBJ7-3;F8WA42;Q8NBJ7-2;E9PBT8;E9PG02;F8WEX5 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 28860200.0 6399700.0 15527000.0 6933500.0 False True 8390068.674782963 13210432.123771952 6216087.930828338 1.0 1.5745320611590445 0.740886418428409 23.0002511888526 -6.721297370894644 1.7549649209659208 1.3490591181611273 0.7421179541568557 0.5185013547501935 0.24172734085166667 0.35279678302444906 2.1242860453354897 0.10934496539470594 0.2740458260821983 1.899777015755063e-07 6.721297370894644 -0.6069411640042717 SVLWWLPVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVLWWLPVEK 10 0 J3KQJ1;Q8NBJ7;C9J660;C9JL30;Q8NBJ7-3;F8WA42;Q8NBJ7-2;E9PBT8;E9PG02;F8WEX5 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 21857300.0 9862800.0 4518500.0 7476000.0 False True 9549710.812623767 6322760.613666213 5517811.324807442 1.0 0.6620892231949216 0.5777987871123222 23.187025614984545 -13.999999999999982 0.1949960637443405 2.843770907509854 0.5202763663337181 0.9994874281778063 0.00413033105767833 12.436354743932029 0.14003340462705605 8.727925558919187 0.055745432311525095 1.0000000000000409e-14 13.999999999999982 -2.323494541176136 SVLWWLPVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVLWWLPVEK 10 0 J3KQJ1;Q8NBJ7;C9J660;C9JL30;Q8NBJ7-3;F8WA42;Q8NBJ7-2;E9PBT8;E9PG02;F8WEX5 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 25662500.0 6399700.0 7773800.0 11489000.0 False True 8765842.035389619 7430327.811481112 8775534.823382378 1.0 0.847645643337315 1.00110574522717 23.063461250375493 -10.942968668439747 8.525846016469963 1.0246843132775034 0.9243756942822425 0.2445962124059291 0.0626498242509436 0.031681307175202865 0.00021192330813001628 0.06537753125996959 0.020220143830560502 1.1403320522344176e-11 10.942968668439747 -0.10030861899526089 SVLWWLPVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVLWWLPVEK 10 0 J3KQJ1;Q8NBJ7;C9J660;C9JL30;Q8NBJ7-3;F8WA42;Q8NBJ7-2;E9PBT8;E9PG02;F8WEX5 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 13088700.0 9862800.0 3225900.0 0.0 False True 8201355.196123512 3208521.436408981 0.0 1.0 0.39121844618137436 0.0 22.96743089041882 -8.316741259880217 0.5326498724321931 1.0350871843961884 5.219388611795841e-24 0.9921408609823554 0.03647633832118599 0.1557386557260014 0.17754819217264958 0.061504579393811196 0.07072757747046834 4.822350137643228e-09 8.316741259880217 -1.0350871843961884 SVLWWLPVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVLWWLPVEK 10 0 J3KQJ1;Q8NBJ7;C9J660;C9JL30;Q8NBJ7-3;F8WA42;Q8NBJ7-2;E9PBT8;E9PG02;F8WEX5 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 17501100.0 4666100.0 5997000.0 6838000.0 False True 6040358.432581828 5663261.67821333 5593554.163804999 1.0 0.9375704672864396 0.9260301729170975 22.52620273039199 -13.999980169427594 0.2374140495527208 1.4081024926223378 0.9208008635005026 0.9995207343910282 0.0007113179294643657 13.533480122988268 0.1542303123575694 2.6145496851706302 0.005725996178509618 1.0000456626229123e-14 13.999980169427594 -0.48730162912183517 SVMEELK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVMEELKR 8 1 P61326;Q96A72;F5H6P7;F5H6N1;F5H3U9 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 11446400.0 2218100.0 7628700.0 1599600.0 True False 3365019.8648311133 6267298.881694844 1283438.3588704139 1.0 1.862484958022497 0.381405878843104 21.68218359089342 -6.748838906956171 1.6541168773196102 1.5078521699990972 0.3787153321108431 0.6439838354648769 0.3624027001245155 0.30206779730227923 1.6257507806903648 0.17309902157577312 0.42075533185287 1.783040028624242e-07 6.748838906956171 -1.1291368378882543 SVMEELK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVMEELKR 8 1 P61326;Q96A72;F5H6P7;F5H6N1;F5H3U9 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 8931700.0 5297100.0 1508400.0 2126200.0 True False 4404773.351318679 1500273.949806043 2570778.5895619486 1.0 0.34060184943611194 0.583634703654462 22.070636356156363 -10.242968581554157 5.5316545399480175 1.0000349180920096 0.46211827654534204 0.8672162124506456 0.09921774726128062 4.27292509010234e-05 5.84775936130394e-06 0.09607338864689019 0.03202239023258389 5.7151998101499023e-11 10.242968581554157 -0.5379166415466676 SVNELIYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVNELIYK 8 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 20881600.0 2101100.0 7884500.0 10896000.0 False True 2754562.4470813433 6708163.333540284 9768586.441812295 1.0 2.4352917976675625 3.546329636550013 21.393391739097154 -7.563167505614557 0.18541493208434046 3.0194784783684607e-19 5.3524849209205385 0.9999547510890529 0.007011541417251901 0.13683490271354823 0.019483168223263223 0.17539920163999878 0.3233880191794864 2.7342139477135676e-08 7.563167505614557 5.3524849209205385 SVNELIYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVNELIYK 8 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 59109700.0 4968000.0 50794000.0 3347700.0 False True 7536819.209449964 41729413.84466661 2686025.6276509655 1.0 5.536740723771722 0.35638716453263464 22.845524355556364 -6.675355996972114 1.918498533607862 3.882371822227885 0.37681759943030907 0.302926943096122 1.9247689426427494 0.44894003686196876 3.1905620230725846 0.8062625838673603 2.1391121401224957 2.1117572945809012e-07 6.675355996972114 -3.505554222797576 SVNELIYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVNELIYK 8 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 22733300.0 2101100.0 9374200.0 11258000.0 False True 2877933.450092523 8960016.847666018 8599092.26578803 1.0 3.113350952357137 2.9879399280450967 21.456601800620046 -10.13058878603126 4.799319417978018 0.999862181547535 3.0506454402155945 0.9972027260332035 0.05119883633053991 17873375.00677377 7.464679750735686 27221.372221026835 0.017526723477646562 7.403059057707435e-11 10.13058878603126 2.0507832586680594 SVNELIYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVNELIYK 8 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 14264700.0 9627800.0 3081400.0 1555500.0 False True 8005942.283858339 3064799.8865899905 1880747.8581806093 1.0 0.3828156359269877 0.23491898785887977 22.93263978446363 -13.999999999999998 0.20068155533682153 4.439769990270937 0.1395106012631988 0.9994869714480852 0.0075051328786233185 12.54445825751426 0.14204278725095687 16.94207189877748 0.09369650151455611 1.0000000000000041e-14 13.999999999999998 -4.3002593890077385 SVNELIYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVNELIYK 8 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 13179700.0 4968000.0 4318400.0 3893300.0 False True 6431173.933920507 4078077.2438213145 3184759.348631469 1.0 0.6341108615196912 0.495206533263517 22.616650677648813 -13.999999999991246 0.13428373471709823 2.741029404947227 0.31086356213134 0.9996266730757302 0.004113821599950816 11.932468792161554 0.1143584747822205 5.46399332634467 0.16424881737022348 1.0000000000201565e-14 13.999999999991246 -2.430165842815887 SVNEVMEWMNNVMNAQAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVNEVMEWMNNVMNAQAK 18 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;Q5TBM3 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 11618400.0 4531800.0 7086600.0 0.0 False True 5866504.435133045 6692224.480377953 0.0 1.0 1.1407516272040765 0.0 22.484069696807747 -6.940314035250139 1.2212472376571444 1.076903631806911 5.805508939241596e-22 0.9683956024370798 0.09028212961030141 0.1119172783434056 0.33258466846793 0.061253404333866786 0.11737930966249192 1.1473236998729242e-07 6.940314035250139 -1.076903631806911 down SVNVK(ub)TQALSGYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVNVKTQALSGYR 13 1 F8W8A5;Q9NYP3;H7C1C1 F8W8A5 DONSON Protein downstream neighbor of Son 1 3587490.0 1274400.0 1444000.0 869090.0 True False 1059720.0654925394 1436220.8853884425 1050812.7007818592 1.0 1.3552832791940315 0.9915946059712097 20.015251783676216 -6.651634289870662 2.004129052809411 1.230262050168467 0.9931658136535425 0.2002336332639535 0.15158152862122157 0.5044705600824111 3.886163230724008 0.06132233492633025 0.16776354832379917 2.230312457336015e-07 6.651634289870662 -0.2370962365149244 SVNVKPLVTHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVNVKPLVTHR 11 1 Q00796 Q00796 SORD Sorbitol dehydrogenase 0 3470220.0 528420.0 1546400.0 1395400.0 False True 692763.7372265594 1315683.1478199898 1251017.3936219595 1.0 1.899180163625846 1.805835563261924 19.402003888490142 -10.036131398273668 4.516583478582843 0.9999629521531086 1.852507863500578 0.991088408114432 0.03810777374642646 6589640.319885253 0.11426189301457777 2589.376135949053 0.013045304527374806 9.201711266076834e-11 10.036131398273668 0.8525449113474695 SVNVKPLVTHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVNVKPLVTHR 11 1 Q00796 Q00796 SORD Sorbitol dehydrogenase 0 4596430.0 1131200.0 741930.0 2723300.0 False True 1095290.6751875752 1038186.5181138365 2009986.0327512177 1.0 0.9478639247394677 1.8351165387279458 20.06288236152603 -6.892948599030936 1.0047430644790285 0.9556419317176404 1.9159971123752564 0.9827205516322809 0.0534380988851741 0.11678467579223804 0.20811797698315398 0.040358676421182585 0.10174723605039959 1.2795327344273795e-07 6.892948599030936 0.9603551806576159 SVNVKPLVTHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVNVKPLVTHR 11 1 Q00796 Q00796 SORD Sorbitol dehydrogenase 0 2878920.0 528420.0 1233000.0 1117500.0 False True 723791.1540135603 1178521.9830142532 853569.5156349381 1.0 1.6282624849435139 1.1793036028441797 19.465213950013034 -10.279866342233055 6.842368835105929 0.9999952277006602 1.4037830438938468 0.5188847336329651 0.1832866961056202 1.3343426335658203e-05 1.404511814332569e-06 0.1774686764666839 0.05915552679987055 5.2496899900063696e-11 10.279866342233055 0.4037878161931866 SVPELK(ub)DALKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVPELKDALKR 11 2 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 21291800.0 2310700.0 4578100.0 14403000.0 True False 3505500.834797916 3761102.286141436 11556240.736940855 1.0 1.0729143889529995 3.296601906987435 21.74118914772866 -6.913875258543102 0.8689225573007016 0.9392985581989217 3.6091401734657906 0.9923037828806356 0.0935056984854386 0.1019109985558628 0.1252774366442237 0.07805255161374097 0.22171105920339831 1.219339776936937e-07 6.913875258543102 2.669841615266869 up SVPELK(ub)DALKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVPELKDALKR 11 2 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 15987100.0 2310700.0 4125300.0 9551100.0 True False 2991246.7007065476 3895723.428569857 7812897.802561858 1.0 1.3023745007891416 2.6119202407198348 21.51231546982111 -6.943052955478663 0.6305206199018574 0.9857147277116234 2.9992205721436136 0.9985370725780726 0.02675744897777967 0.08640102442558943 0.0484712763755084 0.02669387048081581 0.11128315428346411 1.1401107602545642e-07 6.943052955478663 2.0135058444319904 up SVPHLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVPHLQK 7 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 10242200.0 1301200.0 5397100.0 3543900.0 False True 1705885.8008387228 4591873.717731032 3177211.2234892286 1.0 2.6917826008478247 1.8624993665619984 20.702089639146728 -10.066551094940792 5.825937646206738 0.9999953439158722 2.277140983705046 0.7597514024739697 0.3385534627080077 2.0474649200179977e-05 3.2808033322523953e-06 0.32780417614800095 0.10926766023901116 8.579241736206069e-11 10.066551094940792 1.2771456397891738 SVPHLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVPHLQK 7 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 7680100.0 2675800.0 1618500.0 3385800.0 False True 2590858.1936588665 2264775.4903660007 2498957.4081772394 1.0 0.8741410455844499 0.9645288245776806 21.304998623474454 -10.097319145148465 4.51975968407601 1.0000067109636754 0.919334935077855 0.5150142518152518 0.03690065626373301 2.4955926596815604e-06 4.984119658038351e-07 0.035731879250123215 0.011909635596261865 7.992467056264956e-11 10.097319145148465 -0.08067177588582042 SVPHLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVPHLQK 7 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 3942290.0 604470.0 2719600.0 618220.0 False True 917025.1826763734 2234266.1316682147 496028.5460245483 1.0 2.4364283270252436 0.5409104955840688 19.80660182703955 -6.704043501301084 1.81629944750169 1.8883968651445995 0.5460716159414783 0.4368584121847008 0.605896513056818 0.38716860572029776 2.4858177445844833 0.26584344806296556 0.6803255603398769 1.9767716259806128e-07 6.704043501301084 -1.342325249203121 SVPHLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVPHLQK 7 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 9126500.0 1301200.0 4032300.0 3793000.0 False True 1782288.8036078184 3854139.6529670525 2897171.519287086 1.0 2.162466400038684 1.6255342643809767 20.76529970066962 -10.13617655101485 5.483470600084809 0.9999836099178242 1.8940003322100305 0.7870695356435167 0.21920162647807576 4.392363578425261e-05 6.919048270972439e-06 0.21224494300737226 0.07074702073416154 7.308419184988357e-11 10.13617655101485 0.8940167222922063 SVPHLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVPHLQK 7 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 4541840.0 2675800.0 1104500.0 761540.0 False True 2225046.258039024 1098549.8392739142 920774.493036875 1.0 0.4937200003392681 0.41382262939934167 21.08540389890873 -13.999999999999998 0.25988466486733014 4.703982338535133 0.384588383916103 0.9995620985332877 0.005431414768090494 14.411946701893864 0.16132096703501003 28.032723620138132 0.03495109962464063 1.0000000000000041e-14 13.999999999999998 -4.31939395461903 SVPTSTVFYPSDGVATEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVPTSTVFYPSDGVATEK 18 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 43508600.0 3754600.0 22963000.0 16791000.0 False True 4922316.959598118 19537009.90907295 15053628.390645223 1.0 3.969067833183186 3.058240360018237 22.230906128647575 -10.217768202250806 10.162609396970318 0.9999999806229124 3.5136540966007113 0.9103536491680602 0.37184375882711046 2.394280587690974e-07 1.6893163891057697e-08 0.36003617133198146 0.12001205711071378 6.056640520233968e-11 10.217768202250806 2.5136541159777988 SVPTSTVFYPSDGVATEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVPTSTVFYPSDGVATEK 18 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 49702000.0 19911000.0 7889000.0 21902000.0 False True 19278936.203730363 11039118.84059153 16165209.154084075 1.0 0.5725999984613012 0.8384907228935277 24.200522111217968 -10.333037539216246 6.2004133454298715 1.0000215563615227 0.7055453606774145 0.6205212316103191 0.10854943369965497 3.2348723871128867e-05 3.479908409518686e-06 0.10511022052548094 0.03503417907991742 4.644751255397854e-11 10.333037539216246 -0.2944761956841082 SVPTSTVFYPSDGVATEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVPTSTVFYPSDGVATEK 18 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 179763000.0 10598000.0 157450000.0 11715000.0 False True 16077940.817582669 129351817.33753513 9399525.115133103 1.0 8.045297516960463 0.5846224477237707 23.938579309379218 -6.659142492095682 1.9756876276804936 5.538418801448844 0.6157989812371816 0.23180596904779827 3.000402812030757 0.4866644036745506 3.6507530931250773 1.227255779045069 3.3262633864607003 2.1920855936810898e-07 6.659142492095682 -4.922619820211663 SVPTSTVFYPSDGVATEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVPTSTVFYPSDGVATEK 18 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 55830600.0 3754600.0 29890000.0 22186000.0 False True 5142777.084249861 28569360.966987833 16946123.73501275 1.0 5.555239999509922 3.295130910284158 22.294116190170467 -9.572047107003751 12.645603386781204 1.0000000003775285 4.4251854536267174 0.753834197602796 0.9226856719382566 0.0 0.0 0.893386560300267 0.2977955201000889 2.678877736858332e-10 9.572047107003751 3.425185453249189 SVPTSTVFYPSDGVATEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVPTSTVFYPSDGVATEK 18 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 27209200.0 19911000.0 4773200.0 2525000.0 False True 16556878.706859637 4747485.82419398 3052965.8257190855 1.0 0.2867379720687971 0.18439259475001282 23.980927386652244 -13.999999999999998 0.27346313467993827 6.609027764991407 0.15154454836584097 0.9995908210779312 0.007338215120576522 15.055708035338546 0.16557360422121625 47.045500135249156 0.04178317366934085 1.0000000000000041e-14 13.999999999999998 -6.457483216625566 SVPTSTVFYPSDGVATEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVPTSTVFYPSDGVATEK 18 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 30475200.0 10598000.0 10151000.0 9726200.0 False True 13719319.9178119 9586087.92655386 7956131.3992395755 1.0 0.6987290903616998 0.5799217050773827 23.709705631471667 -13.999999999999998 0.12853242895941758 2.4315582332876784 0.4103969843701166 0.9996523093081459 0.003296812987731877 11.939230437469647 0.11134177069259493 4.323822389766209 0.15068626900819435 1.0000000000000041e-14 13.999999999999998 -2.021161248917562 SVPTSTVFYPSDGVATEK(ub)AVELAANTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVPTSTVFYPSDGVATEKAVELAANTK 27 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 15363000.0 2869600.0 5966700.0 6526700.0 True False 3762073.3892459273 5076491.618014441 5851379.692527201 1.0 1.3493866527234273 1.555360325838847 21.84309656206312 -10.304965420275373 0.09425803694025757 4.5779814693379785e-19 2.163560028376863 0.9999328646882949 0.0018782207145540434 2.0965047914903066 0.0487663280298037 0.8286951241867013 0.3457281292749846 4.9548964148622e-11 10.304965420275373 2.163560028376863 SVPTSTVFYPSDGVATEK(ub)AVELAANTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVPTSTVFYPSDGVATEKAVELAANTK 27 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 27129100.0 7882400.0 8584700.0 10662000.0 True False 7632177.526607625 12012615.478619099 7869302.346856206 1.0 1.5739434043220566 1.031069091281211 22.863663298552524 -10.267651580749048 3.8241415008728064 0.9995495898766601 1.3025062473271276 0.2927904719966924 0.2216275111020712 27086901.32936537 18437783.05668869 99297.8887528486 0.0758689921735442 5.3994362665912876e-11 10.267651580749048 0.3029566574504675 SVPTSTVFYPSDGVATEK(ub)AVELAANTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVPTSTVFYPSDGVATEKAVELAANTK 27 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 107334000.0 23165000.0 18934000.0 65235000.0 True False 35142998.588347115 15555079.767982787 52341273.65648378 1.0 0.442622439541645 1.489379841190881 25.066733959256517 -6.762035114045241 1.6046403474414797 0.6770626213252698 1.4936165073740502 0.699274867135399 0.23450953522131046 0.27951574578951593 1.418904390652099 0.1152801854702965 0.27650136298220296 1.7296765038935385e-07 6.762035114045241 0.8165538860487803 SVPTSTVFYPSDGVATEK(ub)AVELAANTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVPTSTVFYPSDGVATEKAVELAANTK 27 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 18572600.0 2869600.0 5736200.0 9966800.0 True False 3930568.6680241292 5482755.716923244 7612847.112689315 1.0 1.394901394682767 1.9368309666286134 21.906306623586012 -6.966693444446829 0.32768926830592165 0.9321713050789505 2.417240836652389 0.9999439177160198 0.002875895769574286 0.07739090634610075 0.012858451733621318 0.007974030088209034 0.047357384729782105 1.0797085874764192e-07 6.966693444446829 1.4850695315734388 SVPTSTVFYPSDGVATEK(ub)AVELAANTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVPTSTVFYPSDGVATEKAVELAANTK 27 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 28608000.0 7882400.0 11283000.0 9442600.0 True False 6554564.849527929 11222216.239499858 11417004.002350502 1.0 1.7121222380320336 1.7418401166894815 22.6440685739868 -11.246117183563088 0.5323353569842192 1.2625910632013102e-14 1.7396622233400971 0.9998747809217221 0.0038372813847159363 3.480512959229482 0.26109507394847076 4.12591695546604 0.00571047393540591 5.6739148827251395e-12 11.246117183563088 1.7396622233400845 SVPTSTVFYPSDGVATEK(ub)AVELAANTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVPTSTVFYPSDGVATEKAVELAANTK 27 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 113916000.0 23165000.0 24456000.0 66295000.0 True False 29987549.15041639 23095002.101448234 54229990.24414333 1.0 0.7701530387029829 1.808416885692385 24.837860281348966 -6.848632160107862 1.241577783310346 0.8774679958402853 1.8488616495527512 0.9383030509839604 0.11059913835344881 0.15896923521322956 0.4722398788162596 0.06972631772249056 0.16122550520473872 1.4169934407020633e-07 6.848632160107862 0.9713936537124659 SVPTWLK(ub)LTSDDVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVPTWLKLTSDDVK 14 1 P62277;J3KMX5;E9PS50 P62277 RPS13 40S ribosomal protein S13 1 36310700.0 13324800.0 6964900.0 16021000.0 True False 20214695.773365304 5721959.177987919 12854442.32774624 1.0 0.2830593763140932 0.6358959081977942 24.268901155747937 -10.634732260450255 6.661394954203357 1.0019935217820584 0.4594776422574305 0.7578162742829526 0.14404491095471922 0.004276396544716566 0.0002344896785166083 0.13985422367315173 0.04649029510279646 2.31882374824035e-11 10.634732260450255 -0.5425158795246279 SVPTWLK(ub)LTSDDVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVPTWLKLTSDDVK 14 1 P62277;J3KMX5;E9PS50 P62277 RPS13 40S ribosomal protein S13 1 8506300.0 4909100.0 1535100.0 2062100.0 True False 6724126.93343925 1467274.2061031463 1575074.450282602 1.0 0.2182103670301575 0.2342422244365611 22.68091552835912 -10.011848542293638 5.630156986583494 1.000002114297652 0.2262262957329379 0.9996781440454707 0.006544978380612388 1.7370845767635517e-07 3.047549515471426e-08 0.006337165437085311 0.0021123826889002588 9.730865229455405e-11 10.011848542293638 -0.7737758185647141 SVPTWLK(ub)LTSDDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVPTWLKLTSDDVK 14 1 P62277;J3KMX5;E9PS50 P62277 RPS13 40S ribosomal protein S13 1 20218400.0 8432800.0 10699700.0 1085900.0 True False 7012246.836382197 10642058.592375832 1312956.6693656829 1.0 1.5176389024357777 0.18723765720190647 22.741445350269995 -6.801153618898047 1.451024269959923 1.2851684758666935 0.16829068935270797 0.8356261883552418 0.22200168974659965 0.2190712393954172 0.9104672531909225 0.12035341437755304 0.2797250723991978 1.580688818199297e-07 6.801153618898047 -1.1168777865139856 down SVPTWLK(ub)LTSDDVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVPTWLKLTSDDVK 14 1 P62277;J3KMX5;E9PS50 P62277 RPS13 40S ribosomal protein S13 1 35593800.0 13324800.0 3944600.0 18324400.0 True False 17249216.271075673 3725079.5424179183 14989547.22422176 1.0 0.21595645181075926 0.8689987410823391 24.040027477840386 -10.596288461440366 8.950843782558678 1.00011139185856 0.5424775964482696 0.3955719374129747 0.26660339819573 0.0005927732789918896 2.673592824210607e-05 0.25819911690077596 0.08604587677119722 2.5334453393727338e-11 10.596288461440366 -0.45763379541029037 SVQFLIQHGFNFNQQYAQGIPYHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVQFLIQHGFNFNQQYAQGIPYHK 24 0 Q96GM8;Q96GM8-2 Q96GM8 TOE1 Target of EGR1 protein 1 0 103812800.0 27823000.0 25473000.0 50516800.0 False True 42209525.1337614 20927144.128542602 40532132.33769996 1.0 0.4957919820757228 0.960260325347281 25.33106526296885 -10.503966396399505 9.108526212677088 1.0000082488244741 0.728026153711502 0.3137397907386209 0.18961840711519634 3.17639078322545e-05 1.7298623093576424e-06 0.1836027952209296 0.06119907774096114 3.1335281721467475e-11 10.503966396399505 -0.2719820951129721 SVQFLIQHGFNFNQQYAQGIPYHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVQFLIQHGFNFNQQYAQGIPYHK 24 0 Q96GM8;Q96GM8-2 Q96GM8 TOE1 Target of EGR1 protein 1 0 84980700.0 27823000.0 27343000.0 29814700.0 False True 36017421.973323375 25821338.01357126 24388730.524655852 1.0 0.7169124440026847 0.6771370405888457 25.1021915850613 -13.999999999974007 0.2764684756865905 3.262872507997944 0.664740252804337 0.9995973903311781 0.002884237857323448 15.210527072029839 0.16651622252667497 19.4204575777361 0.01600263047180439 1.0000000000598521e-14 13.999999999974007 -2.598132255193607 SVQPQSHKPQPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVQPQSHKPQPTR 13 1 Q6PKG0-3;Q6PKG0;A0A0B4J210 Q6PKG0-3 LARP1 La-related protein 1 0 4085660.0 617760.0 2259200.0 1208700.0 False True 809889.3423963492 1922136.1662926252 1083635.318669101 1.0 2.373331843835966 1.338004171610378 19.62736527616009 -10.180815746563319 4.982857148983328 0.9999291358139514 1.855668007724542 0.4766421382585311 0.42267075226077555 0.0003327707176477475 5.470794056452925e-05 0.4092828093821272 0.13641639870223302 6.594536151774283e-11 10.180815746563319 0.8557388719105906 SVQPQSHKPQPTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVQPQSHKPQPTR 13 1 Q6PKG0-3;Q6PKG0;A0A0B4J210 Q6PKG0-3 LARP1 La-related protein 1 0 2867690.0 181080.0 2323700.0 362910.0 False True 274711.59872125584 1909017.579849032 291180.6794308967 1.0 6.949169924878463 1.0599504381551494 18.067558298808997 -6.643820671820687 2.0305080481995046 4.879068566617151 1.0845134147381836 0.1694539893190412 2.54305013823833 0.5238158783489649 4.132120086407096 1.0182218564723016 2.8164266703187852 2.2708023143639483e-07 6.643820671820687 -3.794555151878967 SVQPQSHKPQPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVQPQSHKPQPTR 13 1 Q6PKG0-3;Q6PKG0;A0A0B4J210 Q6PKG0-3 LARP1 La-related protein 1 0 3566960.0 617760.0 1585300.0 1363900.0 False True 846162.5663362788 1515256.2041139444 1041774.9104022315 1.0 1.7907388773704709 1.231175842383239 19.690575337682983 -10.100890254973145 5.9310973466446715 0.9999976249604381 1.5109573598768753 0.5264607524980656 0.2284406524403804 7.174464704379908e-06 1.0875242641075822e-06 0.22118773872445782 0.07372890354151863 7.927016187025802e-11 10.100890254973145 0.5109597349164372 SVQPQSHKPQPTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVQPQSHKPQPTR 13 1 Q6PKG0-3;Q6PKG0;A0A0B4J210 Q6PKG0-3 LARP1 La-related protein 1 0 531680.0 181080.0 164890.0 185710.0 False True 234411.62962043582 155713.72655004088 151912.68554551413 1.0 0.6642747495172308 0.6480595087858666 17.838684620901446 SVSAFAPICNPVLCPWGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVSAFAPICNPVLCPWGK 18 0 U3KQT1;P10768;H7BZT7;X6RA14 U3KQT1 ESD S-formylglutathione hydrolase 0 4295540.0 907940.0 1983400.0 1404200.0 False True 1190318.132503466 1687484.451232648 1258906.8540375226 1.0 1.417675161919567 1.057622176509906 20.182915778862565 -10.357307056458277 6.3026769823457105 0.9999788529708473 1.2376486692147366 0.367435702553646 0.1469910157699044 4.3682307645157355e-05 4.454230457311091e-06 0.14233608987815716 0.04744114634324595 4.3923095896585614e-11 10.357307056458277 0.23766981624388928 SVSAFAPICNPVLCPWGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVSAFAPICNPVLCPWGK 18 0 U3KQT1;P10768;H7BZT7;X6RA14 U3KQT1 ESD S-formylglutathione hydrolase 0 5275440.0 907940.0 2211400.0 2156100.0 False True 1243629.9541559196 2113693.035878117 1646873.5862733698 1.0 1.6996157328107535 1.3242472817335291 20.246125840385456 -10.076263080641812 4.389273929001194 0.999958895023475 1.5119315070794788 0.7126414317792652 0.1532435286251768 53210021.192786716 2.1847687312403314 24281.47615632443 0.05245933586060182 8.389516245567615e-11 10.076263080641812 0.5119726120560038 SVSLTGAPESVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVSLTGAPESVQK 13 0 A0A087WTP3;Q92945;M0R0I5;M0QYH3;M0QXW7 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 7069900.0 3083900.0 0.0 3986000.0 False True 3992169.342757142 0.0 3260588.8998137927 1.0 0.0 0.816746139722096 21.92874148859008 -9.735001610327226 10.5969252503199 1.0000010179619008 0.40837306986104904 0.4116321892604966 0.33343521528502307 0.0 0.0 0.3228472589592607 0.10761575298642022 1.8407651760546387e-10 9.735001610327226 -0.5916279481008517 SVSSK(ub)VYQLPEPGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVSSKVYQLPEPGAR 15 1 Q53HC5 Q53HC5 KLHL26 Kelch-like protein 26 1 25616700.0 3324300.0 8806400.0 13486000.0 True False 4303371.881749587 8316316.098552249 11031686.378045358 1.0 1.9325116041728543 2.563498270932675 22.03703608745691 -8.15295594223531 0.1539484066986738 4.105043620979854e-14 3.7493674024002193 0.9999264422834637 0.005508218636873425 0.08968781562116139 0.030378883090320292 0.31375910542579066 0.34544466506260335 7.031436479051874e-09 8.15295594223531 3.7493674024001784 SVSTTNIAGHFNDESPLGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVSTTNIAGHFNDESPLGLR 20 0 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974;V9GYF5;V9GYG5;V9GZ14 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 0 9782700.0 2445100.0 4501400.0 2836200.0 False True 3205549.778382085 3829808.6663197675 2542737.230751471 1.0 1.194743158302399 0.7932296818160314 21.612140381558067 -6.774807514602497 1.5558767592099836 1.1110138017144997 0.7905403627220905 0.7486405867419788 0.0821934130737403 0.2587404896537145 1.236684252587776 0.04162269602509213 0.09865602617555028 1.6795482524936152e-07 6.774807514602497 -0.3204734389924092 SVTCTYSPALNK(ub)MFCQLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVTCTYSPALNKMFCQLAK 19 1 P04637;P04637-4;P04637-3;P04637-2;P04637-6;P04637-5;J3KP33;A0A0U1RQC9;E7EQX7;E7EMR6 P04637 TP53 Cellular tumor antigen p53 1 34210200.0 7154800.0 7432400.0 19623000.0 True False 9262029.642192941 7018780.406395312 16051815.34898298 1.0 0.7578015486391273 1.7330775185451084 23.14289694357333 -6.840977184650298 1.2778887119341165 0.8711707010802778 1.7657727505778449 0.9261162225288693 0.11270162076962953 0.16765974635996544 0.5314197988370474 0.06914477054302692 0.15933668186871044 1.4421911140125185e-07 6.840977184650298 0.894602049497567 SVTEQGAELSNEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVTEQGAELSNEER 14 0 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 0 55961700.0 6204700.0 23494000.0 26263000.0 False True 8134421.786400263 19988786.77889475 23545556.692485 1.0 2.4573088664167257 2.8945581272722087 22.955608368751154 -9.963101796916305 0.29834957914644133 2.2389452736337654e-22 3.051503448418464 0.9988840910143872 0.027056825202816447 1.3678381243077091 0.13283438004531806 1.3364602588831127 0.15642112130128566 1.0886748823191623e-10 9.963101796916305 3.051503448418464 SVTEQGAELSNEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVTEQGAELSNEER 14 0 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 0 57495500.0 17294000.0 5989500.0 34212000.0 False True 16745011.436256982 8381138.58482987 25250850.862000037 1.0 0.5005155485700468 1.5079625928069458 23.99722802556674 -6.771924093084713 1.5673690203592754 0.7142110192541443 1.5140078586171188 0.7377683492971094 0.21061741693556846 0.2633288121744489 1.2769964449140065 0.10590807697914081 0.2516339308496395 1.6907364163346033e-07 6.771924093084713 0.7997968393629745 SVTEQGAELSNEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVTEQGAELSNEER 14 0 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 0 165417800.0 8906800.0 148870000.0 7641000.0 False True 13512266.774301313 122302985.37338114 6130753.000830734 1.0 9.051255974755215 0.4537175814564793 23.687766381045638 -6.660947808086507 1.969439475669571 6.178432455875117 0.4894482696282867 0.23967073300039377 3.427264527720844 0.48220589903329214 3.596399950972522 1.4054421008067908 3.7999089062654594 2.1829922400581941e-07 6.660947808086507 -5.688984186246831 SVTEQGAELSNEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVTEQGAELSNEER 14 0 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 0 56437700.0 6204700.0 25094000.0 25139000.0 False True 8498745.26571275 23985264.105239 19201685.953956768 1.0 2.8222123802209844 2.2593553934865955 23.018818430274045 -10.089294139415005 5.087169349606446 0.9999641279042996 2.540783886844723 0.9090197264724118 0.22978540262474947 9.350513428720278e-05 1.673985580950199e-05 0.2224939008347399 0.07416291979514603 8.141526870765372e-11 10.089294139415005 1.5408197589404233 SVTEQGAELSNEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVTEQGAELSNEER 14 0 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 0 25063300.0 17294000.0 5185300.0 2584000.0 False True 14380727.254102279 5157365.759698531 3124302.452933907 1.0 0.35863038555489807 0.21725622061587055 23.777633301001018 -13.999999999999998 0.2125017345108874 4.74794249125554 0.1359787169044385 0.9994915635726987 0.007679860453780135 12.806415838214647 0.1460928866785328 20.064387510030386 0.0822990550935243 1.0000000000000041e-14 13.999999999999998 -4.611963774351102 SVTEQGAELSNEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVTEQGAELSNEER 14 0 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 0 25661600.0 8906800.0 9168400.0 7586400.0 False True 11530028.179275999 8658170.480328673 6205753.043037472 1.0 0.7509236183733545 0.5382253145045781 23.458892703138087 -6.972959980842426 0.1734776150542333 1.179350389275918 0.10408348916571299 0.9999972189365492 0.0003146556966403223 0.07535342058371357 0.0054315374745441064 0.008683542041360738 0.024362700060376868 1.0642410808778015e-07 6.972959980842426 -1.075266900110205 SVTK(ub)IYNYYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVTKIYNYYK 10 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 27560600.0 9248800.0 8735900.0 9575900.0 True False 12125266.365506612 7432537.772271484 8585077.726518953 1.0 0.6129793398531201 0.708032093294163 23.531513104705073 -9.84884146591412 6.3002887324703325 1.0000000189758538 0.6605057165735575 0.9444716617687653 0.03880512409650036 1.0317782378724288e-08 1.955046570303127e-09 0.03757290208269352 0.012524299947725666 1.4163106931432757e-10 9.84884146591412 -0.3394943024022963 SVTK(ub)IYNYYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVTKIYNYYK 10 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 44973700.0 14916000.0 17724700.0 12333000.0 True False 22628662.505667407 14561588.801286807 9895377.144254064 1.0 0.6435019655995938 0.4372939470804225 24.431647979109524 -9.730360528056863 0.12225893246239401 1.6990685497358615 8.372149127699416e-11 0.9998803114192634 0.0025429282310175916 1.2276683708195295 0.05219440799984072 0.5038930399680256 0.22497311187182178 1.8605419729339293e-10 9.730360528056863 -1.69906854965214 SVTK(ub)IYNYYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVTKIYNYYK 10 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 27504400.0 9248800.0 7530000.0 10725600.0 True False 12668331.299422083 7197299.701619896 8192434.180665862 1.0 0.5681332080372914 0.6466861330852306 23.594723166227965 -10.800489441886565 7.180136835684213 1.0145019528951478 0.607409670561261 0.9708486718721926 0.03206909736175714 0.007300278886139848 0.00020284864094997462 0.030448367798344093 0.010350256667499138 1.5831080531066305e-11 10.800489441886565 -0.4070922823338867 SVTK(ub)IYNYYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVTKIYNYYK 10 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 40259200.0 11972200.0 21164300.0 7122700.0 True False 9955414.758388083 21050283.715115376 8612023.63835616 1.0 2.114455723442275 0.865059251408885 23.24704999148843 -6.671479104574567 1.9318882885854793 1.710468622107489 0.8700615979085388 0.28555083173637485 0.47324091175433014 0.45783593896369296 3.295604619487711 0.19709713379625454 0.5256268492214692 2.130693080167685e-07 6.671479104574567 -0.8404070241989502 SVTK(ub)IYNYYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVTKIYNYYK 10 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 44607700.0 14916000.0 18158700.0 11533000.0 True False 19309056.038316887 17148152.382219814 9434112.33857312 1.0 0.8880885916013204 0.48858485468435486 24.202774301201973 -6.947490838440636 0.5857447059935005 1.004679718336717 0.35203771590874233 0.9989893651870109 0.006978415770231917 0.08450925382994827 0.040255052683040964 0.007266896675797995 0.0334266352019386 1.1285197437053779e-07 6.947490838440636 -0.6526420024279748 down SVTLGYLFSQGHLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVTLGYLFSQGHLTR 15 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 100502400.0 20127300.0 29870100.0 50505000.0 False True 26387085.21305048 25413597.512737885 45279227.07816905 1.0 0.963107418176255 1.7159616802152486 24.653328659781945 -6.895377761377048 0.9900010168551692 0.9646058310295057 1.7879762326475765 0.9841232799831054 0.04366385783556006 0.11489026743240631 0.1972177518022645 0.03334422740952206 0.08491158465175536 1.2723958343677417e-07 6.895377761377048 0.8233704016180708 SVTLGYLFSQGHLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVTLGYLFSQGHLTR 15 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 79632300.0 35479600.0 12876700.0 31276000.0 False True 34353319.518551186 18018433.46110342 23083877.34011204 1.0 0.5245034166603102 0.6719547823506978 25.03394617581865 -10.865471778737582 10.965185847525936 1.01345400332072 0.5982290995055078 0.9082497615311311 0.06019676796966266 0.018345924550632938 0.000225079603055503 0.05400768421450849 0.019428423320167962 1.3631015802034713e-11 10.865471778737582 -0.41522490381521215 SVTLGYLFSQGHLTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVTLGYLFSQGHLTR 15 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 80303400.0 18351400.0 26302000.0 35650000.0 False True 27840415.467049137 21608202.601536054 28603761.874049947 1.0 0.7761451199286413 1.0274186427966305 24.73067740513162 -6.671718679803485 1.9311082849308485 0.8573270123643865 1.0264146382731336 0.28674202721164355 0.09505100687845887 0.45719238329064144 3.28856135764119 0.039600915397791155 0.10557379550282915 2.1295180237634384e-07 6.671718679803485 0.16908762590874715 SVTLGYLFSQGHLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVTLGYLFSQGHLTR 15 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 95209800.0 20127300.0 30190900.0 44891600.0 False True 27568906.729830697 28856966.210044596 34289128.65152338 1.0 1.0467214566336127 1.2437609146981925 24.716538721304836 -6.943660990782343 0.6245786438383335 0.9978486504607905 1.3031547833890709 0.9986051464168815 0.003945185795030082 0.08613547972906388 0.047297484315679136 0.003956670842551541 0.01670474699681898 1.1385156616062877e-07 6.943660990782343 0.30530613292828035 SVTLGYLFSQGHLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVTLGYLFSQGHLTR 15 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 72564100.0 35479600.0 9579300.0 27505200.0 False True 29502859.412781775 9527694.409557814 33256410.15032413 1.0 0.32294138938377104 1.127226676066394 24.814351451252925 -6.683529452232268 1.8896197773866594 0.5729679412824072 1.1242322050969202 0.340184325733097 0.286737076598432 0.4307551744751572 2.9767575647527322 0.12163349371340491 0.31932496828068757 2.0723855133594293e-07 6.683529452232268 0.551264263814513 SVTLGYLFSQGHLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVTLGYLFSQGHLTR 15 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 88331400.0 18351400.0 43141000.0 26839000.0 False True 23756249.060174886 40740165.42601313 21954577.39139549 1.0 1.7149241583895571 0.9241600951305176 24.50180372722407 -6.668583421479609 1.9422480980002699 1.4568859680091706 0.9273668248283983 0.2728270521413546 0.30378346145937746 0.46439289305580334 3.3759723928466476 0.1259739544230647 0.33721173736249777 2.1449470639668968e-07 6.668583421479609 -0.5295191431807723 SVTLLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVTLLIK 7 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 120772000.0 39661000.0 35577000.0 45534000.0 False True 51995955.077670306 30269050.278059844 40822578.47297 1.0 0.5821424038243872 0.7851106573961419 25.631896060227497 -10.107267081699831 5.026116856222049 1.0000103090817047 0.6836265306093111 0.7641250511304324 0.0828614425424143 115440450.11392027 9.542901429901612 13772.977323746836 0.028365675766932982 7.811472681929461e-11 10.107267081699831 -0.31638377847239363 SVTLLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVTLLIK 7 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 124777000.0 47278000.0 23267000.0 54232000.0 False True 45777185.768668845 32557634.435802095 40027012.27487386 1.0 0.7112196586380246 0.8743877895235194 25.448125437669074 -10.155003776279052 5.072845133038071 1.0000107114092727 0.7928037244887098 0.6825364328684207 0.06661311049317638 8.070132955071332e-06 1.3443462828096406e-06 0.06450120003484813 0.02149928896478703 6.998359107599096e-11 10.155003776279052 -0.20720698692056283 SVTLLIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVTLLIK 7 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 258531000.0 60949000.0 101990000.0 95592000.0 False True 92464088.96875337 83789087.64849283 76698199.30053806 1.0 0.9061797783657166 0.8294917535656128 26.462389827396514 -6.973427225763877 0.15591304572919093 1.0821077313436893 0.6515364504507701 0.9999982669327354 9.161070837655942e-05 0.07520544836777698 0.004793172180945323 0.00369224005744245 0.009345301563229259 1.0630967102667728e-07 6.973427225763877 -0.4305712808929192 SVTLLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVTLLIK 7 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 163006000.0 39661000.0 57632000.0 65713000.0 False True 54324743.49822449 55085627.676461786 50192942.801716946 1.0 1.0140062175951583 0.9239425640980231 25.69510612175039 -6.867170508426037 1.1488716649995057 1.0078017389240101 0.9189421279498625 0.9617814144721328 0.007735848265403491 0.13960137025302352 0.34614134758163084 0.005233897202986657 0.012334917190224521 1.3577802636009062e-07 6.867170508426037 -0.08885961097414763 SVTLLIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVTLLIK 7 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 92729000.0 47278000.0 22554000.0 22897000.0 False True 39313751.77052439 22432497.125381533 27684656.836233623 1.0 0.5706017898347816 0.7041977829495857 25.22853071310335 -10.789112083831064 10.482754055687831 1.0022322451964703 0.6373997863921849 0.9075971925755673 0.05454033580194078 0.002854592152780475 5.742747056312633e-05 0.05297979358817927 0.01760281768812306 1.6251292841e-11 10.789112083831064 -0.3648324588042854 SVTLLIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVTLLIK 7 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 274004000.0 60949000.0 137500000.0 75555000.0 False True 78899681.98440453 129848004.12778603 61804765.25976693 1.0 1.6457354562398874 0.783333515488483 26.233516149488963 -6.7062580336375435 1.8081747337299128 1.3984761702290547 0.7855373678974412 0.4475338265366119 0.27227211719923267 0.3826186059632025 2.436060864241757 0.11992711159101421 0.30610386097610276 1.9667174283442213e-07 6.7062580336375435 -0.6129388023316135 SVTLLIK(ub)GPNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVTLLIKGPNK 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 59774700.0 12262600.0 18342500.0 29169600.0 True False 11873330.475207867 25666755.904873863 21529206.690757506 1.0 2.161714942447478 1.813240752938833 23.501221332647155 -10.082970645824808 4.551948647991592 0.9999446550634369 1.9874778474303647 0.9145782175676989 0.14226399240640655 131814751.4309718 95424546.02227613 103899.5992521177 0.05206329274232081 8.260937837707304e-11 10.082970645824808 0.9875331923669278 SVTLLIK(ub)GPNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVTLLIKGPNK 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 44985600.0 10002600.0 12302000.0 22681000.0 True False 15174675.488012144 10106611.98403529 18198090.408564545 1.0 0.6660183271806651 1.1992408287703333 23.855162328841324 -6.737373988083351 1.6964083059307862 0.8006798950767186 1.1993721967240216 0.5930645214508687 0.14033595621395537 0.3225829949401666 1.8217571975304385 0.06547309620327854 0.1611245052638076 1.830737223446678e-07 6.737373988083351 0.39869230164730307 SVTLLIK(ub)GPNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVTLLIKGPNK 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 26033600.0 5872800.0 7579600.0 12581200.0 True False 8044132.866452508 7244708.209614625 9609779.677947467 1.0 0.9006201575595765 1.1946321421447899 22.939505480429034 -6.81552844099939 1.3912251620033762 0.946181843173876 1.2004498553202105 0.8737658628604272 0.04338555331565262 0.19935384906223305 0.7593642037707568 0.024514053879801864 0.05657614624947078 1.5292255974870043e-07 6.81552844099939 0.25426801214633454 SVTLLIK(ub)GPNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVTLLIKGPNK 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 38866200.0 12262600.0 19856100.0 6747500.0 True False 10196895.225289384 19749131.24817273 8158371.053084949 1.0 1.9367788735528817 0.8000838365830534 23.28162660808143 -6.687800832831204 1.874571365714816 1.5885089944726805 0.80414197214025 0.3600732248595089 0.3963696527259366 0.42136798015022275 2.8691459057747997 0.1692766696933781 0.4419785440133192 2.0521030562018727e-07 6.687800832831204 -0.7843670223324305 SVTLLIK(ub)GPNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVTLLIKGPNK 11 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 27511300.0 10002600.0 11458000.0 6050700.0 True False 12948562.880723305 10820352.227608515 4949534.68542482 1.0 0.8356411693931621 0.3822458701415627 23.626288650933773 -6.953320340702247 0.5211216721817952 1.0076381352748578 0.18997672574046245 0.9994367343332741 0.006199983852116915 0.08217927971401948 0.03065215425942441 0.007011313965726148 0.0374548774675657 1.1134729199310867e-07 6.953320340702247 -0.8176614095343954 down SVTTLAMK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVTTLAMKAK 10 1 Q9UM07 Q9UM07 PADI4 Protein-arginine deiminase type-4 1 3491390.0 993190.0 1032900.0 1465300.0 True False 961661.7270947197 1445342.3565023416 1081493.9719422616 1.0 1.5029633766011168 1.1246095601720238 19.875169977095002 -10.551868202417142 11.051598130705703 0.9999965000526249 1.3137864683865703 0.47837548438223476 0.15446229874765544 1.3320410956167687e-05 5.400368724104368e-07 0.1495591434758374 0.04985249255554868 2.8062851465439485e-11 10.551868202417142 0.31378996833394546 SVTTLAMK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVTTLAMKAK 10 1 Q9UM07 Q9UM07 PADI4 Protein-arginine deiminase type-4 1 3981690.0 993190.0 1679000.0 1309500.0 True False 825881.4907772552 1669954.8937445933 1583310.3955560932 1.0 2.022027267099741 1.9171157281488476 19.655575252529278 -10.542943986699845 6.755890050348904 0.9992079372735232 1.9695714976242922 0.9912953527410884 0.04282995642663523 0.0005113051070368526 3.459127450976852e-05 0.04149747744204187 0.01382330899659562 2.8645474022004524e-11 10.542943986699845 0.970363560350769 SVVALHNLINNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVVALHNLINNK 12 0 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 26135600.0 4957400.0 6028600.0 15149600.0 False True 6499199.407529884 5129156.379298743 13582064.717224624 1.0 0.7891981854497605 2.0898058153883734 22.631830582554116 -6.865354877789601 1.1584657856015048 0.8835599669378486 2.159517856658764 0.9598187570794908 0.11425005310170239 0.14138208441933006 0.35756694978316206 0.0767384656480447 0.1803438592541812 1.3634685416125326e-07 6.865354877789601 1.2759578897209156 up SVVALHNLINNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVVALHNLINNK 12 0 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 16302600.0 4766900.0 2999300.0 8536400.0 False True 4615577.368769138 4196936.131142873 6300460.753489332 1.0 0.9092981865153078 1.3650428213208592 22.138079697143077 -6.854973743070212 1.2107973967511458 0.9513050212131642 1.3850923673695708 0.9472400891170041 0.0452438274248196 0.1520712830119565 0.4265148644309719 0.029197236299719827 0.06781745192646464 1.3964527863846173e-07 6.854973743070212 0.4337873461564066 SVVALHNLINNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVVALHNLINNK 12 0 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 21685520.0 4957400.0 7670500.0 9057620.0 False True 6790284.748697663 7331591.947048527 6918396.70353944 1.0 1.0797178937826848 1.0188669488221902 22.695040644077007 -10.156425099521739 4.1157818023923145 0.9999852668420414 1.0492924213067936 0.46664162633993134 0.02484229430409522 17388990.07890248 0.0008168545861877096 2739.9240666588057 0.008504178098824911 6.97549289154469e-11 10.156425099521739 0.0493071544647522 SVVALHNLINNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVVALHNLINNK 12 0 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 9523300.0 4766900.0 3202400.0 1554000.0 False True 3963888.5594761306 3185148.0355733675 1878934.2151158245 1.0 0.8035412670618364 0.4740128757212451 21.918484972577353 -6.963334086594242 0.3855799762166697 1.021262233609683 0.24453507671683192 0.9998745725842674 0.002430404407935629 0.0785309645761601 0.01688232851573401 0.004267082380003915 0.02777285967062536 1.088092742021029e-07 6.963334086594242 -0.7767271568928511 down SVVALHNLINNK(ub)IANR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVVALHNLINNKIANR 16 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 55744800.0 3455000.0 17757800.0 34532000.0 True False 3345322.9161713873 24848582.145703632 25487033.2622058 1.0 7.427857569619025 7.618706445049219 21.673714046879613 -9.987258522228423 0.807292944826894 1.8923091241667257e-12 7.577891015423698 0.9998869835017467 0.03270168785671856 1.2780161544070086 0.4253133869272229 3.371325590173768 0.027352984280393615 1.02977294560389e-10 9.987258522228423 7.577891015421805 SVVALHNLINNK(ub)IANR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVVALHNLINNKIANR 16 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 107858000.0 33195000.0 61619000.0 13044000.0 True False 50359241.879567586 50622608.01855554 10465847.68261171 1.0 1.0052297478905219 0.20782377359135842 25.585753228745414 -6.90542380666022 0.9263513035861511 1.0284026054234896 0.11426059746406893 0.989076608405256 0.039159085109965755 0.10752207840444494 0.15576393652417597 0.031351642012411106 0.08403038982101274 1.2433007434433243e-07 6.90542380666022 -0.9141420079594207 down SVVALHNLINNK(ub)IANR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVVALHNLINNKIANR 16 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 33567900.0 3455000.0 17463300.0 12649600.0 True False 2872985.582451917 17369221.736706357 15294572.874857878 1.0 6.04570445560078 5.32358149246433 21.45411932231389 -9.874010111315009 5.842420305560971 0.9999987636216425 5.6846429740386215 0.9824910864807098 0.29480546522667517 4.745389891408001e-06 9.173166788605358e-07 0.28544424927621087 0.09514805476301078 1.336564398073734e-10 9.874010111315009 4.6846442104169785 SVVALHNLINNK(ub)IANR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVVALHNLINNKIANR 16 1 P51665 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 56949000.0 33195000.0 16120000.0 7634000.0 True False 42971581.87127444 15222907.829381168 6244690.331454712 1.0 0.35425523488948746 0.14532139752642317 25.356879550837863 -11.533017731542722 0.20428987947274688 2.2843165101405867 5.261528155421802e-15 0.9993667530511974 0.009154657243449172 4.173049273101335 0.12210072739090368 2.489990302277827 0.12623060372344239 2.930773584052533e-12 11.533017731542722 -2.2843165101405813 SVVCAFFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVVCAFFK 8 0 Q8WU90 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 0 13950800.0 4289500.0 4258900.0 5402400.0 False True 5623576.039577091 3623488.7210621773 4843411.47148006 1.0 0.6443388860684232 0.861268957224645 22.42305640330521 -10.352536883882136 5.707916798547839 1.0000498168175085 0.7528039216465331 0.6338793453797837 0.0885613306997355 5.6154807499204647e-05 6.369751668422357e-06 0.08576638447670837 0.028583046576503044 4.4408194464951866e-11 10.352536883882136 -0.2472458951709754 SVVCAFFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVVCAFFK 8 0 Q8WU90 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 0 11160200.0 4289500.0 3553800.0 3316900.0 False True 5875444.06937884 3396781.365154949 2533516.533699798 1.0 0.5781318526812326 0.43120426367494036 22.486266464828102 -13.999999999681556 0.14708146469651087 3.0312995282216506 0.2640020783415398 0.9995762714689688 0.004962609646792848 11.947972617634015 0.12062475689756169 6.942889277917494 0.15030109439837047 1.0000000007332443e-14 13.999999999681556 -2.7672974498801106 SVVCAFFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVVCAFFK 8 0 Q8WU90 Q8WU90 ZC3H15 Zinc finger CCCH domain-containing protein 15 0 4794680.0 1944400.0 485980.0 2364300.0 False True 1616854.751525182 483361.9292805224 2858664.198711933 1.0 0.29895197996268136 1.7680402002810394 20.624758650939487 -6.776922676050738 1.5477801737441208 0.6014766738090056 1.77859554920042 0.7564205616147839 0.29610315061132453 0.25536134575695113 1.2080791779012057 0.15071124422589235 0.35655283872992327 1.6713881700822183e-07 6.776922676050738 1.1771188753914144 SVVCEAVIPAK(ub)VVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVVCEAVIPAKVVR 14 1 P04035-2;P04035;P04035-3;H0Y8F6;H0Y8K6 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 19454500.0 5051600.0 9114400.0 5288500.0 True False 6622696.519763996 7754567.047652939 4741296.750874111 1.0 1.1709078053797455 0.7159163547242039 22.65898731862234 -6.804949820133834 1.4355019438994971 1.0937170248862054 0.7088332732814739 0.8462490842171488 0.07358163315313827 0.21378201833104643 0.8691123371033818 0.04031416756220423 0.09349279033763 1.5669321083309188e-07 6.804949820133834 -0.38488375160473143 SVVCEAVIPAK(ub)VVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVVCEAVIPAKVVR 14 1 P04035-2;P04035;P04035-3;H0Y8F6;H0Y8K6 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 18102300.0 8494500.0 6361900.0 3245900.0 True False 8224846.7471542135 8902239.846870225 2395701.4150872775 1.0 1.0823593582397615 0.2912761159855273 22.97155736681273 -6.881200387325245 1.0731202032294243 1.0518969275111254 0.2339145256362463 0.9746392444141077 0.05655041852311695 0.12657033264713818 0.265926624592308 0.04055013343045864 0.09836338770743855 1.3146181157742683e-07 6.881200387325245 -0.8179824018748791 down SVVCEAVIPAK(ub)VVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVVCEAVIPAKVVR 14 1 P04035-2;P04035;P04035-3;H0Y8F6;H0Y8K6 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 90052000.0 10731000.0 15775000.0 63546000.0 True False 16279711.541185122 12959827.999362431 50986105.24679877 1.0 0.7960723362067009 3.1318801391420177 23.956571801052267 -6.885637710982126 1.047878590754058 0.8610573053432301 3.316391866175063 0.9779547536562057 0.1568400924031281 0.1227524359555193 0.24311317476122604 0.11464982887780345 0.2816758660702534 1.3012546336894833e-07 6.885637710982126 2.455334560831833 up SVVCEAVIPAK(ub)VVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVVCEAVIPAKVVR 14 1 P04035-2;P04035;P04035-3;H0Y8F6;H0Y8K6 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 14615500.0 5051600.0 5229800.0 4334100.0 True False 6919313.034356959 4998730.143364103 3310474.843591399 1.0 0.7224315648885302 0.47843981435059546 22.722197380145232 -6.9726410629519675 0.18449808064066311 1.1777382456336951 0.01650522696025932 0.9999963263105108 0.00040835361494007344 0.07545463488569507 0.005848285904357368 0.009032148890025684 0.027016971111564408 1.0650228779852612e-07 6.9726410629519675 -1.1612330186734359 down SVVCEAVIPAK(ub)VVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVVCEAVIPAKVVR 14 1 P04035-2;P04035;P04035-3;H0Y8F6;H0Y8K6 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 17742900.0 8494500.0 4653500.0 4594900.0 True False 7063553.120155652 4628430.671852568 5555672.345582817 1.0 0.655255307508833 0.7865265895332281 22.751962642247005 -10.0450898766374 5.668603409545036 1.0000010783674156 0.7208909490870191 0.8577046678512702 0.05359127647374991 7.303767521471282e-07 1.2303641480832458e-07 0.051889730573601626 0.01729651010702689 9.013845780210721e-11 10.0450898766374 -0.27911012928039647 SVVCEAVIPAK(ub)VVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVVCEAVIPAKVVR 14 1 P04035-2;P04035;P04035-3;H0Y8F6;H0Y8K6 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 45058300.0 10731000.0 9853300.0 24474000.0 True False 13891491.039633872 9304955.193253191 20019983.12444624 1.0 0.6698312777732199 1.4411687749952211 23.727698123144716 -6.790390568996442 1.494794278260348 0.8155639739750927 1.4494587044588465 0.8025874948124565 0.1403944566859479 0.23476589405832335 1.0362881142516036 0.07392658817694285 0.17302948021148953 1.620352229421742e-07 6.790390568996442 0.6338947304837538 SVVLMSHLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVVLMSHLGR 10 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 7672670.0 1810500.0 824770.0 5037400.0 False True 1753026.6685175938 1154104.96211873 3717953.821239298 1.0 0.6583499172289672 2.1208769313151974 20.741416513080168 -6.845163325014448 1.2581430466039547 0.8181735818629767 2.1741268944591154 0.9329711089844658 0.16173040035614059 0.16286295657265115 0.4985244224471422 0.10069844949278337 0.2324219395324453 1.4283566957569874e-07 6.845163325014448 1.3559533125961387 up SVVLMSHLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVVLMSHLGR 10 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 8472700.0 3423000.0 2122000.0 2927700.0 False True 4688575.603096806 2028243.023484382 2236237.5578741888 1.0 0.43259258145367785 0.47695456939995867 22.160718265525688 -9.852921509696325 6.811477335455703 1.0000000083806375 0.45477357724498474 0.9950594132740234 0.01811070574070096 2.30725379352046e-09 3.8361874453793294e-10 0.017535615691726635 0.005845205143475307 1.4030672588407624e-10 9.852921509696325 -0.5452264311356527 SVVLMSHLGRPDGVPMPDK ddPTM_RPMI8226_Bortezomib_1h_R1 2 SVVLMSHLGRPDGVPMPDK 19 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 141818200.0 64626800.0 39951200.0 37240200.0 False True 84726360.64682156 33990636.68855789 33386941.337222673 1.0 0.40118136113796393 0.3940561247094609 26.336307564792563 SVVLMSHLGRPDGVPMPDK ddPTM_RPMI8226_Bortezomib_2h_R1 2 SVVLMSHLGRPDGVPMPDK 19 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 155057800.0 64028100.0 17019700.0 74010000.0 False True 61995563.01271005 23815754.966562983 54624560.74759208 1.0 0.3841525717200178 0.8811043580069302 25.885661630539758 -10.087127921295638 7.304436765882169 1.0000000789022043 0.6326284648635018 0.42151516765785735 0.20287971719459508 2.605873749962627e-07 3.2860312013326334e-08 0.19643748247418288 0.06547914716482811 8.18223745104153e-11 10.087127921295638 -0.36737161403870255 SVVLMSHLGRPDGVPMPDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVVLMSHLGRPDGVPMPDK 19 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 162976000.0 25449000.0 106533000.0 30994000.0 False True 38607993.57111356 87521353.80387197 24868022.314847205 1.0 2.2669231345229846 0.6441158945243252 25.20239624464464 -6.698378823475208 1.8364558465541927 1.7879359851858616 0.6490505850397047 0.41000851751139034 0.5349414242360584 0.398885953305703 2.614208775461649 0.23247615176853362 0.5991100206235548 2.0027243423016815e-07 6.698378823475208 -1.1388854001461568 SVVLMSHLGRPDGVPMPDK ddPTM_RPMI8226_Carfilzomib_1h_R1 3 SVVLMSHLGRPDGVPMPDK 19 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 226035200.0 68545800.0 80161300.0 77328100.0 False True 93889034.64059405 76619508.70802952 59064795.402210295 1.0 0.8160645063752968 0.6290915188159035 26.484453338667848 -6.970921147117013 0.23514738403478563 1.0713096747539803 0.3684705875743752 0.9999887011157005 0.0005089625570857571 0.07600493920306926 0.007952755827927198 0.0046271408960699145 0.018389513150288795 1.0692490002996742e-07 6.970921147117013 -0.7028390871796051 SVVLMSHLGRPDGVPMPDK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SVVLMSHLGRPDGVPMPDK 19 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 105568100.0 64028100.0 13634500.0 27905500.0 False True 53242202.075771235 13561048.242263662 33740411.02954605 1.0 0.2547048715784587 0.633715543574412 25.666066905974034 -10.698050697383062 6.764085542172839 1.0050408021751092 0.44421020758068674 0.7414145371448801 0.15473045890990783 0.011796019593832849 0.0005265744606716355 0.1502486327688718 0.049939040875758685 2.0042380489028988e-11 10.698050697383062 -0.5608305945944224 SVVLMSHLGRPDGVPMPDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVVLMSHLGRPDGVPMPDK 19 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 58478600.0 25449000.0 15722000.0 17307600.0 False True 32944232.174787242 14847056.87925129 14157794.390972693 1.0 0.4506724212141142 0.4297503221765139 24.97352256673709 SVVLMSHLGRPDGVPMPDKYSLEPVAVELK ddPTM_RPMI8226_Bortezomib_2h_R1 3 SVVLMSHLGRPDGVPMPDKYSLEPVAVELK 30 2 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 197278100.0 122260200.0 29357600.0 45660300.0 False True 118379116.87284999 41080242.77786152 33700497.65036185 1.0 0.3470227170387279 0.2846827932206934 26.818839358298504 -13.999999999999998 0.33221400594707506 8.203675189028392 0.2739265589428873 0.9997194190615651 0.0054190129993942834 19.011932101860236 0.18443192827864244 95.80185765712883 0.01981328982381034 1.0000000000000041e-14 13.999999999999998 -7.929748630085505 SVVLMSHLGRPDGVPMPDKYSLEPVAVELK ddPTM_RPMI8226_Bortezomib_8h_R1 3 SVVLMSHLGRPDGVPMPDKYSLEPVAVELK 30 2 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 1038761000.0 135692000.0 555206000.0 347863000.0 False True 205854684.41398647 456125151.45572203 279107725.5762305 1.0 2.2157627976948353 1.3558483080954702 27.617051037993363 -10.16869205928486 4.814617411006965 0.9999218578406545 1.7858055528985237 0.5268329236170379 0.3510586203356569 0.0002944902800788039 5.084784189030484e-05 0.33994458755670864 0.11330368250689492 6.781221662826186e-11 10.16869205928486 0.7858836950578693 SVVLMSHLGRPDGVPMPDKYSLEPVAVELK ddPTM_RPMI8226_Carfilzomib_2h_R1 3 SVVLMSHLGRPDGVPMPDKYSLEPVAVELK 30 2 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 213957270.0 122260200.0 36679270.0 55017800.0 False True 101664773.34520625 36481671.49224497 66521767.60643457 1.0 0.3588427957083049 0.6543246536394431 26.59924463373278 -10.482407878905168 6.238277977041219 1.0002912929276648 0.5065837246739642 0.7880437241548162 0.12062996336347329 0.0004889903546824082 4.057171067550714e-05 0.11686635471555255 0.0389331532633619 3.2930029600457806e-11 10.482407878905168 -0.49370756825370066 SVVLMSHLGRPDGVPMPDKYSLEPVAVELK ddPTM_RPMI8226_Carfilzomib_8h_R1 3 SVVLMSHLGRPDGVPMPDKYSLEPVAVELK 30 2 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 600120200.0 135692000.0 250580000.0 213848200.0 False True 175655968.88919923 236635002.72247726 174930021.86782748 1.0 1.347150365677255 0.9958672225830841 27.388177360085812 -8.921096115541982 13.445703856043938 0.9999999966006899 1.1715087941301774 0.24117763215761556 0.14341074263699666 0.0 0.0 0.13885685447506846 0.04628561815835614 1.1992338662772622e-09 8.921096115541982 0.17150879752948744 SVVNMEWDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVVNMEWDK 9 0 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 3579400.0 1161600.0 774800.0 1643000.0 False True 1124725.6438276921 1084181.6805286242 1212649.0110565317 1.0 0.9639521304403732 1.0781731684623255 20.10114169471238 -6.821840628783444 1.3637833089368347 0.9806057714807774 1.0807689049955589 0.8885942212741231 0.015913030715523323 0.19109446129143415 0.6978518254279964 0.009167855158301087 0.021121904846875098 1.5071600408904233e-07 6.821840628783444 0.10016313351478145 SVVSWK(ub)TGVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVVSWKTGVFR 11 1 Q9NRW3 Q9NRW3 APOBEC3C DNA dC->dU-editing enzyme APOBEC-3C 1 5543500.0 1097900.0 2003800.0 2441800.0 True False 1439357.5320787246 1704840.850751224 2189145.9593995307 1.0 1.1844457077242563 1.5209188201057726 20.456993567023535 -6.961803356194233 0.40922979812828564 0.9832852231500869 1.734550429404435 0.9998313364504372 0.0028008075973261428 0.0790631647456716 0.018796952909137795 0.004331835251294118 0.028100014561107802 1.0919346406311313e-07 6.961803356194233 0.751265206254348 SVVSWK(ub)TGVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVVSWKTGVFR 11 1 Q9NRW3 Q9NRW3 APOBEC3C DNA dC->dU-editing enzyme APOBEC-3C 1 8558000.0 1490100.0 1767500.0 5300400.0 True False 1442797.5911395017 2473271.9673907342 3912066.231408423 1.0 1.7142196400795056 2.711444942404379 20.460437488875023 -6.966421033622054 0.33276289570362516 0.8823543720381795 3.576091068202263 0.9999395118253054 0.005458742065351 0.07748200445402222 0.013177405186851307 0.014411319248222736 0.08678924108479398 1.080386046166282e-07 6.966421033622054 2.693736696164083 SVVSWK(ub)TGVFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVVSWKTGVFR 11 1 Q9NRW3 Q9NRW3 APOBEC3C DNA dC->dU-editing enzyme APOBEC-3C 1 12176200.0 2473100.0 0.0 9703100.0 True False 3751873.5078282445 0.0 7785278.031980199 1.0 0.0 2.075037448820249 21.839179758396778 -6.775647140929198 1.5526546911706238 0.4305730365601316 2.0893348501420017 0.751739547796804 0.422181032622173 0.257400751235741 1.2252792748942065 0.21422373970869282 0.5073849728714591 1.6763043000702682e-07 6.775647140929198 1.65876181358187 SVVSWK(ub)TGVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVVSWKTGVFR 11 1 Q9NRW3 Q9NRW3 APOBEC3C DNA dC->dU-editing enzyme APOBEC-3C 1 6454000.0 1097900.0 2104600.0 3251500.0 True False 1503823.2996318988 2011611.8130184906 2483562.6667445204 1.0 1.3376650125788627 1.6514989941653646 20.520203628546426 -6.972005277730635 0.20470067762342692 0.8241624656722617 2.173711079189438 0.9999940873244433 0.000646859077982194 0.07565723386148361 0.006648213434794241 0.009805693996172421 0.03293162171423664 1.066583159580836e-07 6.972005277730635 1.3495486135171764 SVVSWK(ub)TGVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVVSWKTGVFR 11 1 Q9NRW3 Q9NRW3 APOBEC3C DNA dC->dU-editing enzyme APOBEC-3C 1 6336300.0 1490100.0 2417400.0 2428800.0 True False 1239084.1726227487 2404376.986383668 2936650.850497625 1.0 1.9404468554338514 2.3700172396534334 20.2408427643093 -9.78747923823474 0.2013476856077184 3.9184225688024293e-16 2.7617629017817618 0.9994308008628573 0.013649639068819726 1.2509847938706533 0.08739284809103047 0.9671522165149492 0.2522140664104695 1.6312508905054263e-10 9.78747923823474 2.7617629017817613 SVVSWK(ub)TGVFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVVSWKTGVFR 11 1 Q9NRW3 Q9NRW3 APOBEC3C DNA dC->dU-editing enzyme APOBEC-3C 1 11450900.0 2473100.0 3403000.0 5574800.0 True False 3201476.702089134 3213620.0585225825 4560243.602278464 1.0 1.0037930485096218 1.4244188000189606 21.610306080489227 -6.908875528310736 0.9033606194531096 0.9865076656586085 1.4774894153700533 0.9904896116247891 0.019424756576775677 0.10516797029185082 0.14283868964728713 0.015815185087520424 0.04332418705021268 1.23345829993244e-07 6.908875528310736 0.4909817497114448 SVVTGGVQSVMGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVVTGGVQSVMGSR 14 0 O60664-4;O60664-3;O60664;K7ERZ3;K7EL96 O60664-4 PLIN3 Perilipin-3 0 7907500.0 1802900.0 2762200.0 3342400.0 False True 2363619.3593084374 2350090.52697127 2996560.51056474 1.0 0.994276222064315 1.2677847212427182 21.172566289842354 -6.902123713689361 0.9477714203458064 0.989281604268208 1.2977622566869256 0.9875928155646049 0.014213654272371598 0.10985808450068234 0.1687460750366495 0.011201551416302826 0.029466766633811998 1.2527842543599382e-07 6.902123713689361 0.3084806524187176 SVVTGGVQSVMGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVVTGGVQSVMGSR 14 0 O60664-4;O60664-3;O60664;K7ERZ3;K7EL96 O60664-4 PLIN3 Perilipin-3 0 5309830.0 1459100.0 613430.0 3237300.0 False True 1412781.6691709599 858375.7979951897 2389354.013081748 1.0 0.6075785216684589 1.6912408089806648 20.43010709858987 -6.808739757231191 1.4198578995517082 0.7858142387489558 1.7096515327053479 0.8565045801099234 0.16969637281903827 0.20852353217610312 0.8287783795708297 0.09398362315743106 0.21752682308086996 1.5533175273344043e-07 6.808739757231191 0.923837293956392 SVVTGGVQSVMGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVVTGGVQSVMGSR 14 0 O60664-4;O60664-3;O60664;K7ERZ3;K7EL96 O60664-4 PLIN3 Perilipin-3 0 7319400.0 1802900.0 2885700.0 2630800.0 False True 2469480.851540533 2758200.2322662077 2009459.223026751 1.0 1.1169150109204384 0.8137172725081844 21.235776351365246 -6.8021491869531525 1.446998654496733 1.0643324314454037 0.8093003052046269 0.838407919864854 0.050189912945269845 0.21770218508810915 0.8996563695149243 0.027283450311862748 0.06337353275940313 1.5770694286024295e-07 6.8021491869531525 -0.25503212624077676 SVVTSIFGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SVVTSIFGVK 10 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 22218800.0 6405400.0 6540000.0 9273400.0 False True 8397541.429981843 5564257.492720339 8313877.524734044 1.0 0.6626055422429004 0.9900370952682541 23.001535577459673 -10.736858376009938 9.60078424448189 1.000516869082538 0.8263213189185074 0.2728000957882267 0.13367337176652838 0.0014830927196064704 4.0648918080505636e-05 0.1297969713571994 0.04314289522359642 1.8329120399015958e-11 10.736858376009938 -0.17419555016403054 SVVTSIFGVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVVTSIFGVK 10 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 18345700.0 6576900.0 2664600.0 9104200.0 False True 6368119.909513051 3728588.675705434 6719536.899854447 1.0 0.5855085533385547 1.055183789773875 22.60243607091414 -6.6736770756501285 1.9239148718425325 0.7362845754037036 1.053338716984228 0.295674069992633 0.17591693939360487 0.4526961015604317 3.2337435024335073 0.07351372677305372 0.1955035418317568 2.11993685128432e-07 6.6736770756501285 0.3170541415805245 SVVTSIFGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SVVTSIFGVK 10 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 18692700.0 6405400.0 5434500.0 6852800.0 False True 8773649.479426328 5194385.820511728 5234309.777846181 1.0 0.5920439188609307 0.5965943579260053 23.064745638982565 -9.968622375970291 5.500258865508634 1.0000008616692577 0.5943191383927686 0.9999056456241487 0.0018577089716380754 1.962920644926875e-08 3.6791636185628973e-09 0.001798722808855557 0.0005995729920809276 1.0749236645575168e-10 9.968622375970291 -0.4056817232764891 SVVTSIFGVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVVTSIFGVK 10 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 11206700.0 6576900.0 2335200.0 2294600.0 False True 5468983.756071783 2322619.8140990906 2774390.2509683194 1.0 0.42468947023667214 0.5072953906451325 22.382841346348417 -10.703953958203554 6.819491535266288 1.0051128603458346 0.46599243044118455 0.9823695382819898 0.03372372578894788 0.0026296522956678657 0.00011415768628660246 0.0327541383029332 0.010884285696055053 1.977179239963193e-11 10.703953958203554 -0.53912042990465 SVVTSIFGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVVTSIFGVK 10 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 13437300.0 3326900.0 5768200.0 4342200.0 False True 4306737.633003252 5447194.599344692 3551964.154734432 1.0 1.2648076255219096 0.8247458882833113 22.038164006418114 -6.743767229677298 1.6729606433021853 1.1568680986855704 0.8242727125625783 0.6217160093194639 0.11125615459692614 0.31103881153167645 1.7106791410247706 0.052581086789303184 0.12849672318122357 1.80398436956442e-07 6.743767229677298 -0.3325953861229921 SVYAHFPINVVIQENGSLVEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SVYAHFPINVVIQENGSLVEIR 22 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7;H0Y9V9 P32969 RPL9 60S ribosomal protein L9 0 770440000.0 210771000.0 281488000.0 278181000.0 False True 319755016.4241101 231254267.12421796 223198403.41893658 1.0 0.723223265456113 0.6980294036197239 28.252391751867787 -13.999999999999998 0.3391528194851801 4.184720959453162 0.6940318929602988 0.9997335087396497 0.0022331802363938546 19.62668286560924 0.1867588318627451 44.793440796836485 0.007807703863835976 1.0000000000000041e-14 13.999999999999998 -3.490689066492863 SVYAHFPINVVIQENGSLVEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SVYAHFPINVVIQENGSLVEIR 22 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7;H0Y9V9 P32969 RPL9 60S ribosomal protein L9 0 441036000.0 210771000.0 97435000.0 132830000.0 False True 272847214.41754425 92012656.59775151 108656302.95089473 1.0 0.33723143112959353 0.3982313075207561 28.023518073960236 -10.344096392864405 6.576123119863566 1.000030732492465 0.36773136934366785 0.9930674236428886 0.02490309525519916 1.1221341526809701e-05 1.119244154961428e-06 0.02411348508999029 0.008037439432700258 4.5279706918476416e-11 10.344096392864405 -0.6322993631487972 SVYWENTLHTLK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SVYWENTLHTLKQR 14 1 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 10899800.0 1961800.0 2018000.0 6920000.0 True False 1899523.7328350279 2823797.9237309783 5107444.4044499 1.0 1.48658207050484 2.6888026278182213 20.85720630661245 -6.9557134422681095 0.4921416590966789 0.9741938185820591 3.2523559704699925 0.9995767089096397 0.01460314004238894 0.08126943124425919 0.02707131248546649 0.01738988204432354 0.0991563147649832 1.1073542013711123e-07 6.9557134422681095 2.2781621518879334 SVYWENTLHTLK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SVYWENTLHTLKQR 14 1 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 10424200.0 1961800.0 2302200.0 6160200.0 True False 1631323.62247588 2289797.5916490797 7448269.338453339 1.0 1.40364398584128 4.565782801053913 20.637611582046727 -6.930488346822606 0.7427735888566767 0.9527744729386327 5.22309914073313 0.9966333451694188 0.09250734623526402 0.0923850377037294 0.0764439608327877 0.08452476597045339 0.2853545245782241 1.1735771719991323e-07 6.930488346822606 4.2703246677944975 up SWCPDCVQAEPVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SWCPDCVQAEPVVR 14 0 Q9BRA2;I3L0K2;I3L3M7 Q9BRA2 TXNDC17 Thioredoxin domain-containing protein 17 0 13821600.0 1397100.0 6191600.0 6232900.0 False True 1831611.6295356473 5267837.414667768 5587979.298198593 1.0 2.876066808990112 3.050853798965704 20.804682199647083 -10.369744231766328 0.49229074869002626 7.268818561057788e-22 3.046120413539317 0.9995085857260324 0.020579106208199152 1.7349110224520363 0.2318072593910786 2.3206274644705682 0.03597457316168868 4.2683081746769574e-11 10.369744231766328 3.046120413539317 SWCPDCVQAEPVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SWCPDCVQAEPVVR 14 0 Q9BRA2;I3L0K2;I3L3M7 Q9BRA2 TXNDC17 Thioredoxin domain-containing protein 17 0 11011300.0 1397100.0 4594600.0 5019600.0 False True 1913645.6252078756 4391595.379689607 3834073.8619070607 1.0 2.29488434109244 2.0035443403950888 20.867892261169974 -10.131864575124323 5.228182304974443 0.9999667623267386 2.1492143407447246 0.9540151578807952 0.11893905723178842 4.6080908690536424e-05 7.651832850068513e-06 0.11516555897707463 0.038387415655544155 7.381343646920611e-11 10.131864575124323 1.1492475784179859 SWGLILGTLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SWGLILGTLGR 11 0 I3L1H5;Q9BZG8-3;Q9BZG8-2;Q9BZG8 I3L1H5 DPH1 Diphthamide biosynthesis protein 1 0 7572100.0 1803900.0 3188800.0 2579400.0 False True 2364930.3689924516 2713043.4698450454 2312508.431351934 1.0 1.147198033995776 0.9778336232102888 21.173366276022822 -6.676931824009262 1.912526171237197 1.0933914569721077 0.978490126796055 0.310105670286866 0.06242883714871727 0.4454648197615956 3.1474855037249574 0.026216391658231496 0.06942362343660716 2.1041087189748517e-07 6.676931824009262 -0.11490133017605275 SWGLILGTLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SWGLILGTLGR 11 0 I3L1H5;Q9BZG8-3;Q9BZG8-2;Q9BZG8 I3L1H5 DPH1 Diphthamide biosynthesis protein 1 0 10584300.0 4713000.0 2416300.0 3455000.0 False True 4563388.394765773 3381141.1908380394 2550031.8522217395 1.0 0.7409277708459406 0.5588022827832576 22.121674017619345 -7.658052667555633 0.11273994548915457 1.419892205550679 1.2389715760221115e-10 0.9999927394419845 0.0004877561638508887 0.1372714287442403 0.01254065000946669 0.06310988110548742 0.08701351754617233 2.1975933511197297e-08 7.658052667555633 -1.419892205426782 SWGLILGTLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SWGLILGTLGR 11 0 I3L1H5;Q9BZG8-3;Q9BZG8-2;Q9BZG8 I3L1H5 DPH1 Diphthamide biosynthesis protein 1 0 13814000.0 1803900.0 4461000.0 7549100.0 False True 2470850.5785645167 4263898.269445724 5766158.058594824 1.0 1.7256803411895951 2.3336733142093817 21.236576337545713 -6.973165713783311 0.1659757630239694 0.4328063608773215 3.6427677781339374 0.9999977197836255 0.0008232165351718012 0.07528825528552835 0.005155159727015647 0.026595648848217975 0.07141468072137733 1.0637370505375937e-07 6.973165713783311 3.2099614172566158 SWGLILGTLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SWGLILGTLGR 11 0 I3L1H5;Q9BZG8-3;Q9BZG8-2;Q9BZG8 I3L1H5 DPH1 Diphthamide biosynthesis protein 1 0 8642300.0 4713000.0 1899100.0 2030200.0 False True 3919068.3213012684 1888869.1713581623 2454705.433415792 1.0 0.48196893151660886 0.6263492320544041 21.90207929305362 -10.530771855645302 9.505007542789775 1.0000154583406358 0.554159081785536 0.9270818906832927 0.05894301087121366 1.9309182247566326e-05 9.532972741103577e-07 0.05707329646091709 0.019023774956627777 2.94596880898931e-11 10.530771855645302 -0.4458563765550998 SWGLILGTLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SWGLILGTLGR 11 0 I3L1H5;Q9BZG8-3;Q9BZG8-2;Q9BZG8 I3L1H5 DPH1 Diphthamide biosynthesis protein 1 0 9296100.0 1688400.0 5016400.0 2591300.0 False True 2185667.0833396544 4737232.930230007 2119709.9889833103 1.0 2.1674082783877644 0.9698228999013139 21.05964223849866 -6.652003441298348 2.001103901496971 1.7563435275472332 0.9748388717621128 0.2021942095793845 0.4980218055606769 0.5037356314297828 3.8686251015625626 0.20166511687744615 0.5517779990764924 2.2284174914824802e-07 6.652003441298348 -0.7815046557851204 SWHDIEK(ub)DNAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SWHDIEKDNAR 11 1 A0A2R8YFH5;Q15437;Q5QPE2 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 9910200.0 2535000.0 4033200.0 3342000.0 True False 3323409.548974921 3431462.281290468 2996201.898727675 1.0 1.0325126141461785 0.9015445898480461 21.664232658883662 -6.84102233376178 1.2778539035654175 1.0172932130688597 0.8971549248961119 0.9261612741110885 0.015130299246216481 0.16761167887548908 0.5312463969615386 0.00928337414799661 0.02139071306114686 1.442041192091753e-07 6.84102233376178 -0.12013828817274774 SWHDIEK(ub)DNAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SWHDIEKDNAR 11 1 A0A2R8YFH5;Q15437;Q5QPE2 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 17846900.0 3025100.0 6047000.0 8774800.0 True False 2929069.8563560247 8461598.634688418 6476416.641642636 1.0 2.888834698266726 2.2110830260974956 21.48201117026307 -10.250320724470972 5.483905354811713 0.9998800086393326 2.549958862182193 0.8745812979376306 0.2766909615224016 0.0004059469799351325 5.549471678212205e-05 0.26792498556112054 0.0893016238351563 5.619261920222719e-11 10.250320724470972 1.5500788535428605 SWHDIEK(ub)DNAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SWHDIEKDNAR 11 1 A0A2R8YFH5;Q15437;Q5QPE2 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 10384200.0 2535000.0 3693000.0 4156200.0 True False 3472258.0057991277 3529831.0488821017 3174591.1596258865 1.0 1.0165808655309656 0.914272831778025 21.727442720406554 -6.865357939626345 1.1584483695077052 1.0091588626937407 0.9087888041225577 0.9598221996418261 0.00898675908201409 0.14137911334058414 0.35754653291875055 0.006036222719215621 0.014185866876221491 1.3634589290027987e-07 6.865357939626345 -0.10037005857118297 SWHDIEK(ub)DNAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SWHDIEKDNAR 11 1 A0A2R8YFH5;Q15437;Q5QPE2 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 17241600.0 3025100.0 9634700.0 4581800.0 True False 2515504.684652763 9582795.958761774 5539833.196150367 1.0 3.8094923922133623 2.2022750464148224 21.262416445697347 -9.740419410883721 6.523707076989253 0.9999999889672165 3.0058837193151016 0.6749902054025876 0.6561437338297458 1.1468565016479009e-07 2.3218291522058788e-08 0.635308433725197 0.21176947948621175 1.817944368550374e-10 9.740419410883721 2.005883730347885 SWHDIEK(ub)DNAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SWHDIEKDNAR 11 1 A0A2R8YFH5;Q15437;Q5QPE2 A0A2R8YFH5 SEC23B Protein transport protein Sec23B 1 38312500.0 7562800.0 7796700.0 22953000.0 True False 9790193.685075304 7362806.791149886 18775789.51766832 1.0 0.7520593593949162 1.9178159413016662 23.222905971107544 -6.8511022597310856 1.2297225758152202 0.8675537094258299 1.9654289009748451 0.9419008109689984 0.12086250024014407 0.15624663448185264 0.45412001267697216 0.0768843735102825 0.17804886473429374 1.4089570039039197e-07 6.8511022597310856 1.0978751915490153 SWHDVQVSSAYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SWHDVQVSSAYK 12 0 O43399-2;O43399-4;O43399-3;O43399-6 O43399-2 TPD52L2 Tumor protein D54 0 8554600.0 2194300.0 2588700.0 3771600.0 False True 2876748.5496314275 2202476.050673568 3381351.011741856 1.0 0.7656129872580459 1.1754072187418254 21.45600769305914 -6.751577663946466 1.6440367460384042 0.8624404292183181 1.176319445435552 0.6557303776806852 0.09849944435647878 0.2972959765288916 1.5814578602685336 0.047319729241595665 0.11468847162884213 1.7718311640529087e-07 6.751577663946466 0.3138790162172338 SWHDVQVSSAYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SWHDVQVSSAYK 12 0 O43399-2;O43399-4;O43399-3;O43399-6 O43399-2 TPD52L2 Tumor protein D54 0 6528790.0 2388800.0 775790.0 3364200.0 False True 2312968.851563009 1085566.9926914047 2483015.096163349 1.0 0.4693392182769012 1.073518605529612 21.14131440685117 -6.674740351380628 1.9207553512724949 0.6626712655041458 1.0711250749176735 0.3001746614324132 0.22516984249831828 0.450296657907114 3.207195525847143 0.09423103647541356 0.2501987903487118 2.1147529946180957e-07 6.674740351380628 0.4084538094135277 SWHDVQVSSAYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SWHDVQVSSAYK 12 0 O43399-2;O43399-4;O43399-3;O43399-6 O43399-2 TPD52L2 Tumor protein D54 0 5959200.0 2388800.0 2288100.0 1282300.0 False True 1986393.04178325 2275773.551147711 1550423.0013146852 1.0 1.1456813950096576 0.7805217641735293 20.921719682285445 -6.798428288646357 1.4622189664684158 1.0805387982559342 0.7756681563554095 0.8275691858104101 0.062323364791281866 0.22300056131622678 0.9414481196082741 0.03353294583048958 0.07806466715275717 1.590639310878447e-07 6.798428288646357 -0.3048706419005247 SWHDVQVSSAYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SWHDVQVSSAYK 12 0 O43399-2;O43399-4;O43399-3;O43399-6 O43399-2 TPD52L2 Tumor protein D54 0 7420700.0 2797700.0 3372300.0 1250700.0 False True 3621677.8009117185 3184628.5405100505 1023085.4332657082 1.0 0.8793240910906968 0.28248935700689815 21.788226773341954 -6.940049139429436 0.659109052574381 1.0066936793851846 0.12131064190267811 0.9981702901572506 0.013417994680036533 0.08774430782592753 0.05450823983926945 0.013066243894322021 0.051357291685563834 1.1480237178843311e-07 6.940049139429436 -0.8853830374825065 down SWHDVQVSSAYVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SWHDVQVSSAYVK 13 0 O43399;O43399-5;O43399-7;A0A087WYR3 O43399 TPD52L2 Tumor protein D54 0 26729500.0 9228900.0 10557000.0 6943600.0 False True 12099177.272794724 8981936.750863684 6225142.879714381 1.0 0.7423592983516138 0.5145096017157924 23.52840561379294 -6.972573523423952 0.1867519033005064 1.1611340880131962 0.08953116296348858 0.9999961176716416 0.0003907294290550524 0.07547614888995796 0.005935161128359966 0.008271434033951586 0.02506606427939665 1.0651885184412114e-07 6.972573523423952 -1.0716029250497077 SWHDVQVSSAYVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SWHDVQVSSAYVK 13 0 O43399;O43399-5;O43399-7;A0A087WYR3 O43399 TPD52L2 Tumor protein D54 0 14491900.0 5032000.0 2986500.0 6473400.0 False True 4872261.914377544 4179025.024391759 4777822.342162714 1.0 0.8577176469228565 0.980616893370172 22.21616025848328 -10.35957158529629 5.060459439569021 1.0000464219249987 0.9191672701487259 0.3657985679268705 0.050173407261451405 2.629297307335746e-05 3.3275247772274964e-06 0.048608078884795694 0.01619339756216821 4.3694665067796406e-11 10.35957158529629 -0.0808791517762728 SWHDVQVSSAYVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SWHDVQVSSAYVK 13 0 O43399;O43399-5;O43399-7;A0A087WYR3 O43399 TPD52L2 Tumor protein D54 0 21607500.0 9899000.0 6810900.0 4897600.0 False True 15017506.713837618 5595441.681195419 3929587.213305666 1.0 0.3725945849612704 0.26166708550127143 23.840141973057978 -13.999999999999956 0.24372884755384874 5.229132480946834 0.21432642225484969 0.9995313083655093 0.007037692034962932 13.758043967041836 0.1562372544837806 28.380937183612456 0.05304086797124241 1.0000000000001022e-14 13.999999999999956 -5.014806058691985 SWHDVQVSSAYVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SWHDVQVSSAYVK 13 0 O43399;O43399-5;O43399-7;A0A087WYR3 O43399 TPD52L2 Tumor protein D54 0 24678800.0 9228900.0 7601900.0 7848000.0 False True 12641073.731644789 7266022.921878378 5994464.0346335545 1.0 0.5747947584301418 0.47420528998477623 23.591615675315833 -13.999999999999998 0.20250338298266674 3.3865029756731047 0.4104659427592334 0.9994872081464526 0.005160396588698771 12.581480714525425 0.14267715529780875 11.905389345869718 0.06287472225295598 1.0000000000000041e-14 13.999999999999998 -2.9760370329138714 SWHDVQVSSAYVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SWHDVQVSSAYVK 13 0 O43399;O43399-5;O43399-7;A0A087WYR3 O43399 TPD52L2 Tumor protein D54 0 12307800.0 5032000.0 4370600.0 2905200.0 False True 4184330.9553974075 4347054.710303828 3512663.8878729013 1.0 1.0388888347123981 0.8394804152242985 21.996565533917558 -6.856102720078686 1.2052151609116717 1.0209184865096217 0.8305161687555991 0.9487300788219697 0.019542740466626827 0.15087203927411716 0.4186537705377515 0.012665221455575786 0.029447564462654015 1.3928273300646284e-07 6.856102720078686 -0.1904023177540226 SWLLPVIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SWLLPVIR 8 0 Q5JTH9-2;Q5JTH9-3;Q5JTH9 Q5JTH9-2 RRP12 RRP12-like protein 0 4277500.0 1112200.0 1219600.0 1945700.0 False True 1458104.9705601202 1037640.4339635656 1744377.6284723 1.0 0.7116363052825777 1.196331995084147 20.475663153910293 -6.745521939604948 1.6663602976271645 0.8295371682672211 1.1969813015779884 0.6295720759937896 0.12115446087028152 0.3078869088359329 1.6805872074515784 0.0574699978393494 0.1401870489053417 1.796710312015495e-07 6.745521939604948 0.3674441333107673 SWLLPVIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SWLLPVIR 8 0 Q5JTH9-2;Q5JTH9-3;Q5JTH9 Q5JTH9-2 RRP12 RRP12-like protein 0 5636200.0 1112200.0 1441400.0 3082600.0 False True 1523410.3960748666 1377714.1819276102 2354553.368139831 1.0 0.9043618091863826 1.545580477989674 20.538873215433185 -6.868936939359445 1.139642953870449 0.9462382085847232 1.5823922593391877 0.9636138639291371 0.05387641415418821 0.13788150259389828 0.33535043494006217 0.036710822512872415 0.08676153165728852 1.3522689017524047e-07 6.868936939359445 0.6361540507544645 SWLPQNCTLVDMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SWLPQNCTLVDMK 13 0 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 20619700.0 4271200.0 7123700.0 9224800.0 False True 5599584.56235964 6060871.727965108 8270306.186529935 1.0 1.0823788194406843 1.4769499584170696 22.41688836577011 -6.9407685568101165 0.6523783104920686 0.9956230415818162 1.5858014362811954 0.9982627974534191 0.008675819764080392 0.08741782049637521 0.05302684966742734 0.00849525429121946 0.03384660870565762 1.1461235681900509e-07 6.9407685568101165 0.5901783946993792 SWLPQNCTLVDMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SWLPQNCTLVDMK 13 0 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 35389200.0 5979400.0 19750000.0 9659800.0 False True 9071186.952694265 16225458.192545697 7750536.295959262 1.0 1.7886808283370808 0.8544125852964862 23.112859907148266 -6.68289456357647 1.8913519495421631 1.497692154319511 0.8578604174776275 0.3375610050990927 0.33404991008129586 0.4321080763676518 2.9909099488632527 0.14158488967546354 0.37207590558946557 2.0754173185114457e-07 6.68289456357647 -0.6398317368418834 SWLPQNCTLVDMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SWLPQNCTLVDMK 13 0 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 19453900.0 4271200.0 7944100.0 7238600.0 False True 5850378.064839937 7593103.394374321 5528991.763646593 1.0 1.2978825146374646 0.9450657209446282 22.480098427293 -6.682843478413778 1.8913861566505796 1.1879820745825331 0.9463626556950151 0.33741902611146724 0.12617045329580825 0.43220403679479447 2.9915992463267598 0.053474667695511464 0.14054471537377228 2.0756614599216356e-07 6.682843478413778 -0.24161941888751803 SWLPQNCTLVDMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SWLPQNCTLVDMK 13 0 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 21952000.0 5979400.0 7744600.0 8228000.0 False True 7740451.171595064 7313606.201949456 6730588.426409406 1.0 0.9448552855404617 0.8695343820665744 22.883986229240715 -6.966768241837936 0.3263056847827525 1.0095808986637667 0.8023566609204409 0.9999450614622309 0.0003963119296485075 0.07736617512763662 0.012772486197753532 0.0011139876326638088 0.006589578911885207 1.0795226481316292e-07 6.966768241837936 -0.20722423774332577 SWLSYSYQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SWLSYSYQSR 10 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 112789000.0 25454000.0 34526000.0 52809000.0 False True 33370440.496886607 29374855.38129389 47344831.25969773 1.0 0.8802657364991782 1.418765546835227 24.992067394737745 -6.84835980143466 1.2429194958115848 0.9361819712456294 1.4396279932766547 0.937891477253165 0.05753491446348877 0.15927179349050183 0.4743020249123276 0.036236067622108126 0.08377233723868031 1.417882357114606e-07 6.84835980143466 0.5034460220310253 SWLSYSYQSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SWLSYSYQSR 10 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 70224000.0 22906000.0 17894000.0 29424000.0 False True 34750076.65291086 14700675.893539855 23608333.50300269 1.0 0.42304009974920287 0.6793750050915391 25.05051282439739 -10.382073474103041 5.956006259788884 1.0000936852636955 0.5512075524203794 0.8034240039412633 0.10464828689222612 0.00013021172774046989 1.3509201774578144e-05 0.10134625033185064 0.033775089361893794 4.1488384649215006e-11 10.382073474103041 -0.448886132843316 SWLSYSYQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SWLSYSYQSR 10 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 83125000.0 25454000.0 20595000.0 37076000.0 False True 34865031.66848556 19685044.801442433 28319412.40418881 1.0 0.5646071108902996 0.8122583301648534 25.055277456260637 -10.173458781810023 5.453545538438113 1.00000968214694 0.6884327205275259 0.6784962850004415 0.10110318690030627 1.1902363555500467e-05 1.8037311556318633e-06 0.0978957812488071 0.03263091325942268 6.70719940631157e-11 10.173458781810023 -0.31157696161941406 SWLSYSYQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SWLSYSYQSR 10 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 60889000.0 24865000.0 19456000.0 16568000.0 False True 20676349.20627116 19351186.666286387 20032292.198223274 1.0 0.9359092590880188 0.96885054505403 24.30147813772839 -10.181801293687498 4.535842646481492 1.0000092591165728 0.9523799020702995 0.7358945065861758 0.013448223683774149 1.2594467048823324e-06 2.2717126056003347e-07 0.01302371838300314 0.0043403955299302095 6.579588097819101e-11 10.181801293687498 -0.047629357046273246 SWLSYSYQSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SWLSYSYQSR 10 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 96825000.0 22906000.0 39959000.0 33960000.0 False True 29652268.54476316 37735246.52321594 27779628.459025722 1.0 1.2725922290313367 0.9368466502685792 24.82163914648984 -6.690759897192031 1.863631943698765 1.1707781699794062 0.9379948287875399 0.37396807927210807 0.11527001824337177 0.4150682529146691 2.7955463420637328 0.049469120623978416 0.12870175039447124 2.038168582345305e-07 6.690759897192031 -0.23278334119186628 SWMEGLTLQDYSEHCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SWMEGLTLQDYSEHCK 16 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 8188800.0 1617700.0 3288900.0 3282200.0 False True 2120820.365829086 2798208.9400317925 2942589.4290855657 1.0 1.3193993159990696 1.3874769765968502 21.016190998630833 -12.576621197662686 0.23947234320615263 1.193270313451626e-12 1.419578546941572 0.99942743584941 0.0040418342593790445 6.9101929695296604 0.14677211332271844 3.357691056101907 0.03334198134168583 2.650811233371018e-13 12.576621197662686 1.4195785469403788 SWMEGLTLQDYSEHCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SWMEGLTLQDYSEHCK 16 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 7017800.0 1617700.0 2783900.0 2616200.0 False True 2215807.4066987187 2660898.092873789 1998307.4423303118 1.0 1.200870655468293 0.9018416656109769 21.079401060153725 -6.725699980598607 1.7387282031408937 1.1214566709401523 0.9021486532909222 0.5393047526277746 0.08447355285235635 0.3443572713398915 2.0374122350782864 0.038531293062260163 0.09608836452893685 1.8806155353637353e-07 6.725699980598607 -0.21930801764923014 SWNETLTSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SWNETLTSR 9 0 O75947;O75947-2;F5H608 O75947 ATP5H ATP synthase subunit d, mitochondrial 0 3831010.0 1150000.0 456110.0 2224900.0 False True 1113493.879478174 638237.1015822277 1642131.9444307205 1.0 0.5731842027558608 1.4747561479190947 20.08666219743573 -6.777958776079885 1.5436879553688772 0.7576850266353442 1.4814625328449282 0.7601387234987196 0.1803471976535866 0.2537632257865765 1.1942540063291092 0.09202762654459881 0.21753228527142807 1.6674054778085603e-07 6.777958776079885 0.723777506209584 SWPEGHFATITLTFIDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SWPEGHFATITLTFIDK 17 0 O95433;G3V438 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 0 80046000.0 17196000.0 30527000.0 32323000.0 False True 26087589.19599468 25079218.341460384 25934344.882325828 1.0 0.9613467213486667 0.9941257771073618 24.636860292319184 -10.353628235498997 5.3954267276886325 1.0000072468043588 0.9777362492280155 0.3808415073601312 0.013381993476508735 1.166916630230866e-06 1.3979551933957712e-07 0.012961276963727213 0.004319019822797623 4.429673987985947e-11 10.353628235498997 -0.02227099757634332 SWPEGHFATITLTFIDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SWPEGHFATITLTFIDK 17 0 O95433;G3V438 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 0 49040000.0 17196000.0 14631000.0 17213000.0 False True 22260560.983835958 13816771.988317335 14080410.620294748 1.0 0.6206839081166955 0.6325272139601039 24.407986614411634 -9.956649782511937 5.549324184767436 1.0000006057302306 0.6266055610377999 0.9992460465724657 0.004835009366125703 3.623329021476762e-08 6.807111070192556e-09 0.00468148525613861 0.0015604925625066438 1.1049693141300464e-10 9.956649782511937 -0.3733950446924308 SWPEPDQK(ub)PEPVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SWPEPDQKPEPVDK 14 1 Q96S82;H3BV23 Q96S82 UBL7 Ubiquitin-like protein 7 1 47617000.0 11471000.0 11788000.0 24358000.0 True False 14849435.627214625 11131987.437515207 19925093.934185725 1.0 0.7496572743218312 1.3418081625721128 23.823904764712918 -6.79189776592594 1.4892306652275715 0.8604267419452781 1.3483955028203862 0.8072598433318976 0.10655234015340882 0.23254079574167677 1.0188674565716418 0.05631679296204849 0.1316436064927517 1.6147386258496398e-07 6.79189776592594 0.4879687608751081 SWPEPDQKPEPVDK(ub)VAAMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SWPEPDQKPEPVDKVAAMR 19 2 Q96S82;H3BV23 Q96S82 UBL7 Ubiquitin-like protein 7 1 58473000.0 11961000.0 15304000.0 31208000.0 True False 15680986.83048876 13020702.854524761 27978895.528274424 1.0 0.8303497091910331 1.7842560440057682 23.902513017711446 -6.860930254342818 1.1809225811447892 0.9077085128845054 1.8312991104504395 0.9547678228150971 0.08836834132380328 0.14585220514438516 0.38595958925381224 0.05833830649328137 0.1363342197368932 1.3774306600369218e-07 6.860930254342818 0.9235905975659341 SWPEPDQKPEPVDK(ub)VAAMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SWPEPDQKPEPVDKVAAMR 19 2 Q96S82;H3BV23 Q96S82 UBL7 Ubiquitin-like protein 7 1 70565000.0 16428000.0 24233000.0 29904000.0 True False 15906502.132232549 33909363.27342553 22071245.299229767 1.0 2.1317925834060287 1.3875612070931127 23.923113283583046 -10.126132480516693 4.837535487128459 0.9999549957282411 1.759676895254233 0.581458737558884 0.3038311871053978 0.0001474845712900647 2.6642996764846487e-05 0.29420063614675446 0.09806109397418107 7.479413079601794e-11 10.126132480516693 0.7597218995259919 SWPEPDQKPEPVDK(ub)VAAMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 SWPEPDQKPEPVDKVAAMR 19 2 Q96S82;H3BV23 Q96S82 UBL7 Ubiquitin-like protein 7 1 162656000.0 43843000.0 76384000.0 42429000.0 True False 66513036.35263996 62752678.409084044 34042889.55270866 1.0 0.9434643469947879 0.5118228157893663 25.98713379637544 -6.930977218197325 0.7387363719594805 1.0063320560336004 0.42096576845881867 0.9967266164381253 0.012474167588401388 0.09213400186500122 0.07522039720472679 0.011431246279401923 0.03884851494202645 1.1722568570592257e-07 6.930977218197325 -0.5853662875747818 SWPEPDQKPEPVDK(ub)VAAMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SWPEPDQKPEPVDKVAAMR 19 2 Q96S82;H3BV23 Q96S82 UBL7 Ubiquitin-like protein 7 1 65765000.0 11961000.0 19209000.0 34595000.0 True False 16383304.933871139 18360282.86433156 26424373.506389868 1.0 1.1206702761402665 1.612884189914554 23.965723079234337 -6.944426141147042 0.6170203721819019 0.9946000841850197 1.764897709303802 0.998687980341976 0.009602102984194623 0.0858042946881876 0.0458427148063122 0.009696522651380636 0.041609841372142076 1.1365115635423202e-07 6.944426141147042 0.7702976251187824 SWPEPDQKPEPVDK(ub)VAAMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SWPEPDQKPEPVDKVAAMR 19 2 Q96S82;H3BV23 Q96S82 UBL7 Ubiquitin-like protein 7 1 85546200.0 22610700.0 38979000.0 23956500.0 True False 18801798.873848177 38769012.390274264 28965693.3876591 1.0 2.061984209617246 1.5405809615349146 24.164367363466898 -10.140997973451922 4.590523980850514 0.9999097260691931 1.8012825855903078 0.7589738629854812 0.21286198472133674 148771790.93803954 25.55069895555497 143586.69302816337 0.072868319159599 7.227731762703359e-11 10.140997973451922 0.8013728595211147 SWPEPDQKPEPVDK(ub)VAAMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SWPEPDQKPEPVDKVAAMR 19 2 Q96S82;H3BV23 Q96S82 UBL7 Ubiquitin-like protein 7 1 162183800.0 43843000.0 81113000.0 37227800.0 True False 56755627.77473375 76598990.24594249 30452722.389485165 1.0 1.349628102960435 0.5365586389133729 25.758260118467888 -6.789830389816259 1.4968617600254388 1.195447211752976 0.5279323419338671 0.800835098613689 0.14861823572142155 0.2355947791857644 1.0428112607981297 0.07814869479984766 0.18299958605732008 1.6224436058222368e-07 6.789830389816259 -0.6675148698191089 SWQGTADGGMMDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SWQGTADGGMMDR 13 0 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 0 7134900.0 0.0 3311200.0 3823700.0 False True 0.0 2817181.8669565106 3428060.2035203427 0.0 SWQGTADGGMMDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SWQGTADGGMMDR 13 0 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 0 4548610.0 873320.0 628790.0 3046500.0 False True 845596.9346311984 879869.1260965313 2248530.2569590504 1.0 1.0405301746751014 2.659104077688896 19.68961062126102 -6.912281801420996 0.8800569967222601 0.9534297601198023 2.8788140472591897 0.991754450839309 0.07016805019810225 0.1029282569294072 0.13072734284403045 0.058103694033130655 0.16304416911410513 1.2238218381544332e-07 6.912281801420996 1.9253842871393874 up SWQGTADGGMMDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SWQGTADGGMMDR 13 0 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 0 3274000.0 0.0 1335500.0 1938500.0 False True 0.0 1276493.194092081 1480666.2246606948 0.0 SWQGTADGGMMDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SWQGTADGGMMDR 13 0 Q15424-2;Q15424;Q15424-4;Q15424-3 Q15424-2 SAFB Scaffold attachment factor B1 0 1926400.0 0.0 1926400.0 0.0 False True 0.0 1819194.1465583018 0.0 0.0 SWTAADMAAQTTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SWTAADMAAQTTK 13 0 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913;A0A140T955;A0A140T933;A0A1W2PPQ2;A0A1W2PRT9 Q53Z42 HLA-A 0 12133200.0 3564800.0 5929200.0 2639200.0 False True 4673487.3215723075 5044586.471840576 2366120.900994036 1.0 1.0794051903287114 0.5062859355736946 22.15606804944563 -6.871869344987782 1.124217351346725 1.0454545643428552 0.47151541149091786 0.9665106495690916 0.04639732688119679 0.1350721395583497 0.3179303210086405 0.031992783892946526 0.07599660990509602 1.3431689850715491e-07 6.871869344987782 -0.5739391528519373 SWTAADMAAQTTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SWTAADMAAQTTK 13 0 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913;A0A140T955;A0A140T933;A0A1W2PPQ2;A0A1W2PRT9 Q53Z42 HLA-A 0 12714300.0 3950200.0 4596300.0 4167800.0 False True 3824803.0632301625 6431626.559387854 3076128.148680104 1.0 1.6815575738313047 0.8042579180749296 21.86695403555674 -6.699349174559274 1.8332804660331723 1.4234899271221446 0.8069062179986366 0.41446519835136575 0.28772815087317655 0.39686857337291476 2.5927490657174395 0.12523358309285187 0.3223159534498386 1.9982546186248633e-07 6.699349174559274 -0.616583709123508 SWTAADMAAQTTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SWTAADMAAQTTK 13 0 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913;A0A140T955;A0A140T933;A0A1W2PPQ2;A0A1W2PRT9 Q53Z42 HLA-A 0 30458700.0 8644100.0 9770600.0 12044000.0 False True 13113731.668358784 8026960.091953765 9663498.120927267 1.0 0.6121034267706927 0.7368991805927868 23.644574944231206 -10.83378243774287 10.598631115863492 1.0056346977637218 0.6745013036817401 0.900701381101079 0.05094765315501901 0.0067728269233720195 0.00010621754331837483 0.049253041937075026 0.016443284349811696 1.4662821992937627e-11 10.83378243774287 -0.3311333940819817 SWTAADMAAQTTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SWTAADMAAQTTK 13 0 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913;A0A140T955;A0A140T933;A0A1W2PPQ2;A0A1W2PRT9 Q53Z42 HLA-A 0 16552700.0 3564800.0 6553700.0 6434200.0 False True 4882802.895097725 6264135.86381225 4914574.476508568 1.0 1.282897548475972 1.006506832672427 22.21927811096852 -10.72784412129576 3.9975786929995114 0.9881829094371045 1.1447021905744401 0.2676470590195049 0.1128360372276763 0.012707362524603926 0.0008651190612080181 0.11682394615849306 0.03641767441946036 1.8713536935573037e-11 10.72784412129576 0.1565192811373356 SWTAADMAAQTTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SWTAADMAAQTTK 13 0 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913;A0A140T955;A0A140T933;A0A1W2PPQ2;A0A1W2PRT9 Q53Z42 HLA-A 0 12497700.0 3950200.0 5272900.0 3274600.0 False True 3284766.323531566 5244493.8411113 3959303.7199602826 1.0 1.5966109380568547 1.2053532367268969 21.647359310991018 -10.184890914015957 4.895410693261008 0.9999589955576305 1.40098208739283 0.5834087992155657 0.1597302877020733 7.149149400376465e-05 1.190336317953631e-05 0.15467396785738857 0.05155272867911725 6.532946264285434e-11 10.184890914015957 0.4010230918351996 SWTAADMAAQTTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SWTAADMAAQTTK 13 0 Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913;A0A140T955;A0A140T933;A0A1W2PPQ2;A0A1W2PRT9 Q53Z42 HLA-A 0 35902300.0 8644100.0 8911200.0 18347000.0 False True 11189957.850684837 8415283.886425642 15008034.25611734 1.0 0.7520389262154923 1.3412056109933277 23.415701266323655 -6.792398627906057 1.48699273007271 0.8618453835280699 1.3478694450551933 0.80892388754478 0.10557747001395053 0.2317963431954593 1.0125007743287437 0.055881380045446245 0.13059256478051287 1.612877457827811e-07 6.792398627906057 0.4860240615271234 SWVFTYAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SWVFTYAQR 9 0 Q8WW59 Q8WW59 SPRYD4 SPRY domain-containing protein 4 0 35091500.0 5369500.0 14642000.0 15080000.0 False True 6950923.598668717 13827159.828647565 12335594.733866539 1.0 1.9892550439334173 1.7746698778604224 22.72877325689984 -10.178400216746542 5.790057868815599 0.9999845732023264 1.8819624608969407 0.9574896626721426 0.08760402720829208 1.7448590409056165e-05 2.476006242409874e-06 0.0848237148525002 0.02827407820318859 6.631316909294582e-11 10.178400216746542 0.8819778876946144 SWVGFSGGQHHTVCMDSEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SWVGFSGGQHHTVCMDSEGK 20 0 P18754;P18754-2;C9JW69 P18754 RCC1 Regulator of chromosome condensation 0 130773000.0 38106000.0 38670000.0 53997000.0 False True 49957335.019028954 32900586.73447944 48409908.41579841 1.0 0.6585736953732113 0.9690250370112593 25.574193182442862 -10.367102535747984 8.135838035513318 1.0000013207781897 0.8137993668730119 0.3241592090460611 0.12674122949594577 3.036366794743386e-06 2.3622738877252983e-07 0.12271753813221592 0.040905555926304175 4.294350263514548e-11 10.367102535747984 -0.1862019539051778 SWVGFSGGQHHTVCMDSEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SWVGFSGGQHHTVCMDSEGK 20 0 P18754;P18754-2;C9JW69 P18754 RCC1 Regulator of chromosome condensation 0 25941100.0 12925100.0 4911600.0 8104400.0 False True 12514799.775342043 6872827.49365563 5981614.513211538 1.0 0.5491759849963551 0.47796326114598614 23.577131873701077 -13.999999999999998 0.25975057250625394 4.2959586043784475 0.4518732274343589 0.9995618250916747 0.004838387324117581 14.405979158354851 0.1612783563003394 24.91949199947521 0.031173930180396707 1.0000000000000041e-14 13.999999999999998 -3.8440853769440886 SWVGFSGGQHHTVCMDSEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SWVGFSGGQHHTVCMDSEGK 20 0 P18754;P18754-2;C9JW69 P18754 RCC1 Regulator of chromosome condensation 0 52712100.0 16034800.0 31742000.0 4935300.0 False True 24325963.90090348 26077392.098622005 3959835.7917811694 1.0 1.0719983062070348 0.1627822769084229 24.53599363622725 -6.887748656769601 1.0356392837951665 1.0515226484828335 0.0879541018180676 0.9794166025695747 0.0592077765816377 0.12098754256504168 0.23268544503558064 0.043685261630636234 0.10805868248176881 1.294945060064427e-07 6.887748656769601 -0.9635685466647659 down SWVGFSGGQHHTVCMDSEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SWVGFSGGQHHTVCMDSEGK 20 0 P18754;P18754-2;C9JW69 P18754 RCC1 Regulator of chromosome condensation 0 106087000.0 38106000.0 32578000.0 35403000.0 False True 52194817.975929625 31138596.23896053 27041540.547672264 1.0 0.5965840565498386 0.5180886071897569 25.637403243965753 -13.999999999999998 0.2301505485665954 3.5484211478605756 0.4799780773232097 0.9995099994392227 0.004673337545940816 13.29598915675377 0.15189952841297727 15.485229011329562 0.040708093420542095 1.0000000000000041e-14 13.999999999999998 -3.068443070537366 SWVGFSGGQHHTVCMDSEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SWVGFSGGQHHTVCMDSEGK 20 0 P18754;P18754-2;C9JW69 P18754 RCC1 Regulator of chromosome condensation 0 27303200.0 12925100.0 4991200.0 9386900.0 False True 10747793.3290157 4964311.4149243655 11349657.38987821 1.0 0.4618912238963758 1.055998849478959 23.357537149135354 -6.668152746404967 1.9435297587049263 0.6559978239439918 1.0536018102977784 0.2711077008641479 0.2286718130100826 0.46534032785906787 3.3868322345565147 0.09477277695365864 0.253856797259684 2.1470751900773685e-07 6.668152746404967 0.3976039863537867 SWVGFSGGQHHTVCMDSEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SWVGFSGGQHHTVCMDSEGK 20 0 P18754;P18754-2;C9JW69 P18754 RCC1 Regulator of chromosome condensation 0 54750600.0 16034800.0 22226000.0 16489800.0 False True 20757364.69316198 20989103.561775763 13488825.599636115 1.0 1.0111641758016674 0.6498332422747136 24.3071199583197 -6.899771534619492 0.9627268188246624 1.0151171334924602 0.6120830650475492 0.9864518516546517 0.01952709000585337 0.11157310777294673 0.17837666903376242 0.015219213589490665 0.039551924546680675 1.259587857557472e-07 6.899771534619492 -0.4030340684449111 SWVNQMESQTGEASK(ub)LPYDVTPEQALAHEEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SWVNQMESQTGEASKLPYDVTPEQALAHEEVK 32 1 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 33433500.0 14958000.0 8113500.0 10362000.0 True False 19363425.866260674 7661976.59266029 8476222.323098477 1.0 0.39569323350010666 0.4377439396128586 24.20683088764099 -10.23912484797317 6.0218952574663716 1.0000152745233992 0.4167185865564805 0.9961170482329417 0.017167128883337126 3.520544676588716e-06 4.448560159395359e-07 0.016622435500944163 0.005540667022278939 5.766006823894065e-11 10.23912484797317 -0.5832966879669188 SWVQCGISMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SWVQCGISMK 10 0 A0A0C4DG89;Q7L014;D6RJA6 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 11922100.0 3707200.0 2827800.0 5387100.0 False True 4860175.100575868 2405903.2626780663 4829694.568712105 1.0 0.49502398841412065 0.9937285115797265 22.21257686097042 -10.93748464607115 10.383878282655129 1.0573389024505624 0.7443762499969236 0.2594301966808267 0.20359526902895456 0.11511862516474705 0.0006930620654985928 0.08396927498543771 0.06571009052631326 1.1548228112589666e-11 10.93748464607115 -0.31296265245363875 SWVQCGISMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SWVQCGISMK 10 0 A0A0C4DG89;Q7L014;D6RJA6 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 11319600.0 3707200.0 3331900.0 4280500.0 False True 5077852.023313027 3184685.640880121 3269534.059664746 1.0 0.6271718093120571 0.6438813192377256 22.27578692249331 -10.231734272020471 8.282340938615887 1.000000157989121 0.6355265642813244 0.9984261143704719 0.006821628861643138 1.989759009073318e-08 1.847870360959318e-09 0.006605016548765963 0.0022016712479293156 5.86496909504129e-11 10.231734272020471 -0.36447359370779653 SWWDAVCTLIHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SWWDAVCTLIHR 12 0 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 0 6969960.0 2066700.0 2985860.0 1917400.0 False True 2709463.713951273 2540381.326791122 1719005.8409995313 1.0 0.9375956259205354 0.6344450498259915 21.369575895520605 -6.940451149943592 0.6553570067681239 1.0033781726371318 0.5515996089688482 0.9982223394062952 0.006731678682644247 0.0875615449485159 0.053677763563476755 0.006575375771829008 0.02604015733707828 1.1469615260186178e-07 6.940451149943592 -0.4517785636682836 SWWDAVCTLIHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SWWDAVCTLIHR 12 0 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 0 80366800.0 19642700.0 21223600.0 39500500.0 False True 29799411.973724417 17436082.759256322 31693208.861315817 1.0 0.585114994035136 1.0635514851521652 24.828780526745895 -6.67737667900226 1.9110025992625992 0.7368846992129822 1.0617038546120279 0.31223696562163783 0.17593940215805917 0.44438480281767345 3.135264933428589 0.07393375182896873 0.1956678075115903 2.1019545492120682e-07 6.67737667900226 0.3248191553990457 SWWDAVCTLIHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SWWDAVCTLIHR 12 0 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 0 19984900.0 2066700.0 5264200.0 12654000.0 False True 2830814.8404674814 5031610.237618522 9665385.817310527 1.0 1.7774423694866601 3.414347586122723 21.432785957043496 -6.9590269818161845 0.4489360696641756 0.9466354331897183 4.309931422631229 0.9997323934104627 0.016461014756145673 0.0800505393291891 0.022429480079486735 0.021844567388267 0.13542076234270659 1.0989375625981269e-07 6.9590269818161845 3.363295989441511 SWWDAVCTLIHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SWWDAVCTLIHR 12 0 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 0 25822700.0 8419100.0 1745600.0 15658000.0 False True 7000854.679369297 1736196.1063255307 18932015.4055879 1.0 0.24799773539677925 2.7042434492146143 22.739099629441547 -6.824525416712744 1.3521320781331831 0.5964226296846398 2.763275105811459 0.8944891714174475 0.33377962594785404 0.18766349993434137 0.6728888655203322 0.19391785053718844 0.44651375704130297 1.497871588827292e-07 6.824525416712744 2.1668524761268193 SWWDAVCTLIHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SWWDAVCTLIHR 12 0 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 0 43731200.0 19642700.0 14810700.0 9277800.0 False True 25427862.365503307 13986471.52534834 7589335.598267033 1.0 0.550045116821266 0.2984653404669635 24.599906848838344 -9.125095772095932 0.18382995080420297 1.4515865607148983 4.173812390633488e-24 0.9996638027333392 0.005320865662131978 0.5706116605724335 0.06318259591365752 0.29829912552870247 0.15043491888126298 7.497288583440113e-10 9.125095772095932 -1.4515865607148983 SYAK(ub)FSATPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYAKFSATPR 10 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 5537470.0 886170.0 1945700.0 2705600.0 True False 1161777.451682488 1655409.1442791962 2425650.4659478143 1.0 1.4248935042437172 2.0878787606309483 20.14790230407019 -6.964593706473533 0.3649647936429042 0.946014875801037 2.5896533050155592 0.9999045150221001 0.004374331464902094 0.07809918107441324 0.015348198878778597 0.008811397718645076 0.056463646975344436 1.0849414296784988e-07 6.964593706473533 1.6436384292145223 up SYAK(ub)FSATPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYAKFSATPR 10 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 13507800.0 0.0 4805500.0 8702300.0 True False 0.0 6724361.210351438 6422906.566596008 0.0 SYAK(ub)FSATPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYAKFSATPR 10 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 6502270.0 886170.0 2235700.0 3380400.0 True False 1213810.9968437927 2136919.381528766 2582019.1415233514 1.0 1.760504219425662 2.1272003205089067 20.21111236559308 -9.930326799621595 0.1759921596471788 9.610816632821796e-18 2.5471968968357666 0.9995842937940717 0.009571467445768216 1.4529118938356052 0.07982702420965292 0.9525010453632493 0.2595544613593712 1.1740137959506456e-10 9.930326799621595 2.5471968968357666 SYAK(ub)FSATPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYAKFSATPR 10 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 13660100.0 0.0 8940600.0 4719500.0 True False 0.0 8892435.213229856 5706325.629497511 0.0 SYCAEIAHNVSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYCAEIAHNVSSK 13 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 131543000.0 36811000.0 50008000.0 44724000.0 False True 48259577.478231095 42547001.32965729 40096389.50290142 1.0 0.8816281358627593 0.830848333079337 25.524311948751336 -13.999999997992086 0.11549290494508592 1.5666060566075204 0.7446505538757748 0.999715306804192 0.0011957620533276886 11.983262630876505 0.10398051763897095 1.5685274282406076 0.07649289956792617 1.0000000046233924e-14 13.999999997992086 -0.8219555027317456 SYCAEIAHNVSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYCAEIAHNVSSK 13 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 35907300.0 20677400.0 6521000.0 8708900.0 False True 20021007.2552365 9124869.306565752 6427777.828600251 1.0 0.45576474700987585 0.3210516707104766 24.255011222080736 -13.999999999999963 0.1960901416579017 3.981446054596598 0.2301135741556082 0.9994871959466078 0.006646486501483494 12.456303082680119 0.14042386899151696 14.22130842525101 0.08834802472883894 1.0000000000000858e-14 13.999999999999963 -3.7513324804409898 SYCAEIAHNVSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYCAEIAHNVSSK 13 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 221501000.0 42504000.0 139713000.0 39284000.0 False True 64481675.4586275 114780123.56734852 31519500.181211162 1.0 1.7800425120931191 0.4888132939634081 25.942385894808954 -6.743171670318498 1.6751095986007813 1.4624319190213746 0.4875388836185792 0.618981604586587 0.3277300930244667 0.31216168600891736 1.7210484643842596 0.15470125202802587 0.37830564413581047 1.8064599174209693e-07 6.743171670318498 -0.9748930354027954 SYCAEIAHNVSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYCAEIAHNVSSK 13 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 104236000.0 36811000.0 32062000.0 35363000.0 False True 50421021.47987049 30645394.82514433 27010987.723846346 1.0 0.6077900432338295 0.5357088557721883 25.587522010274228 -13.999999999999998 0.23823756249211364 3.5740624246654074 0.503300713484473 0.9995220827280157 0.004459982868417199 13.561880833920863 0.15449280445181263 16.590826010833734 0.03559013697372764 1.0000000000000041e-14 13.999999999999998 -3.070761711180934 SYCAEIAHNVSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYCAEIAHNVSSK 13 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 32438300.0 20677400.0 5277200.0 6483700.0 False True 17194174.26413637 5248770.676157818 7839411.6927583385 1.0 0.305264480604091 0.45593417702586586 24.035416497515012 -10.131871836220325 7.78069237338244 1.000000108976664 0.38059932882226644 0.9575075326253414 0.061510645988898806 1.1632272902147808e-07 1.2888915942892483e-08 0.05955743753183503 0.019852475627455426 7.381220237116828e-11 10.131871836220325 -0.6194007801543975 SYCAEIAHNVSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYCAEIAHNVSSK 13 0 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 0 107938000.0 42504000.0 35462000.0 29972000.0 False True 55022265.8790977 33488508.526396677 24517403.538690187 1.0 0.6086355767314657 0.4455905831388899 25.713512216901403 -13.999999999999993 0.12008508102310143 2.8651850574540485 0.18565904815692016 0.9996925242932493 0.0040794490126478825 11.963420927095775 0.10665972660305024 5.324627426787275 0.23066089365415277 1.0000000000000164e-14 13.999999999999993 -2.6795260092971285 SYCAEIAHNVSSK(ub)NR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYCAEIAHNVSSKNR 15 1 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 1 7565600.0 2652700.0 2038300.0 2874600.0 True False 3477715.38878334 1734193.5852311705 2577163.967110284 1.0 0.49865885829083584 0.7410508563818649 21.729708438716187 -10.14005993935509 4.986542499891126 1.0000195803911134 0.6198548573353975 0.7663251346044172 0.09895611884608925 2.1542202251297312e-05 3.7147878575257935e-06 0.09581878094615434 0.03193795002421255 7.243359836080324e-11 10.14005993935509 -0.3801647230557159 SYCAEIAHNVSSK(ub)NR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYCAEIAHNVSSKNR 15 1 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 1 7283100.0 2652700.0 1784500.0 2845900.0 True False 3633474.876522027 1705654.889447634 2173757.0331503097 1.0 0.46942801241556736 0.5982584459840924 21.79291850023908 -10.072175693780142 7.539068793458542 1.000000047162925 0.5338432291999139 0.945819562864386 0.05259480426406866 4.17383382837705e-08 5.133353277399283e-09 0.05092470556476997 0.016974900084314733 8.468847377121737e-11 10.072175693780142 -0.466156817963011 SYCAEIAHNVSSK(ub)NR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYCAEIAHNVSSKNR 15 1 D3YTB1;F8W727;P62910 D3YTB1 RPL32 60S ribosomal protein L32 1 9945900.0 1818500.0 3805700.0 4321700.0 True False 2354084.0979940505 3593909.4495208394 3535194.9443866736 1.0 1.5266699488702473 1.5017283993375874 21.16673442988395 -10.106525995517519 4.705551337415268 0.999967875012036 1.5141991741114083 0.9982385113922723 0.010182344983915386 7092371.756119967 0.19001507541681384 2468.6588378215033 0.0034856875186352713 7.824813667628521e-11 10.106525995517519 0.5142312990993723 SYCFTANK(ub)PDGSIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYCFTANKPDGSIR 14 1 Q9BVK2-2;Q9BVK2;E9PKA5;E9PK79;E9PP96;H0YDD3;H0YEE0;H0YD42 Q9BVK2-2 ALG8 Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase 1 143436000.0 9796000.0 84808200.0 48831800.0 True False 14861248.183528973 69673514.10050897 39180173.32626169 1.0 4.688267986650648 2.6363985610364735 23.825051955899863 -10.299011623448003 6.558051427868853 0.999932683100898 3.6623332738435557 0.6918079595051926 0.8376721852620562 0.0008245301194535194 8.813250183457222e-05 0.811092256281606 0.27035753525842626 5.023291450162373e-11 10.299011623448003 2.662400590742658 SYCFTANK(ub)PDGSIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYCFTANKPDGSIR 14 1 Q9BVK2-2;Q9BVK2;E9PKA5;E9PK79;E9PP96;H0YDD3;H0YEE0;H0YD42 Q9BVK2-2 ALG8 Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase 1 42751900.0 4136900.0 4575100.0 34039900.0 True False 5666423.725518897 4372956.954167482 26000376.693746492 1.0 0.7717313716716505 4.588498487441571 22.43400705735293 -6.892687465810685 1.006332274088423 0.8079374523028928 4.934617443017328 0.9825639871192107 0.23080546704999938 0.11699036510999929 0.20931937399592748 0.17410718843245906 0.43847661960693435 1.2803023250854657e-07 6.892687465810685 4.126679990714435 up SYCFTANK(ub)PDGSIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYCFTANKPDGSIR 14 1 Q9BVK2-2;Q9BVK2;E9PKA5;E9PK79;E9PP96;H0YDD3;H0YEE0;H0YD42 Q9BVK2-2 ALG8 Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase 1 88019900.0 9796000.0 48562500.0 29661400.0 True False 12681115.108028455 45859954.185131624 24263329.551665027 1.0 3.616397595515677 1.9133435305152175 23.596178277992312 -10.376545890243063 6.20581625410014 0.99976140127675 2.764870563015439 0.5887960359757947 0.6952689106039713 0.0022955062106784032 0.00023061250029898737 0.6732743297228779 0.2243970759920795 4.2019812459670156e-11 10.376545890243063 1.765109161738689 SYCNDQSTGDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYCNDQSTGDIK 12 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 9503200.0 1452200.0 4909800.0 3141200.0 False True 1903848.263124803 4177276.978250507 2816178.756518064 1.0 2.194122850627972 1.4792033646083984 20.860487069629322 -10.115838124132598 4.72870971184005 0.9999508054639742 1.8366631076269322 0.6461560844284889 0.2918646580408507 0.00016972920098148176 3.1736139383011855e-05 0.28261526531074543 0.09419891332038585 7.658820231888234e-11 10.115838124132598 0.836712302162958 SYCNDQSTGDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYCNDQSTGDIK 12 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 5003550.0 2887600.0 779550.0 1336400.0 False True 2795934.718592328 1090828.3802995463 986356.748859373 1.0 0.3901480149181547 0.3527824674518778 21.414899245394245 -13.867051315888713 0.398191984695763 9.999171156770997 0.35046639975736343 0.999832894386037 0.0038352429617922196 23.715256829776976 0.20750437430837887 183.5108702469391 0.009612654824463373 1.3581529588381743e-14 13.867051315888713 -9.648704757013633 SYCNDQSTGDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYCNDQSTGDIK 12 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 35729000.0 4552100.0 28390000.0 2786900.0 False True 6905868.503087191 23323582.68791755 2236067.9934583353 1.0 3.3773569070263942 0.3237924371798748 22.71939143294638 -6.698921364775151 1.8345954992784381 2.4777894044273854 0.33302142259522116 0.41251183821499915 1.0037099883906646 0.3977721900039305 2.6020306091224406 0.4365799693776642 1.1243161729687006 2.000224005999304e-07 6.698921364775151 -2.1447679818321643 SYCNDQSTGDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYCNDQSTGDIK 12 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 9443700.0 1452200.0 3935600.0 4055900.0 False True 1989117.584229384 3761712.178711183 3097979.953882549 1.0 1.8911462090203834 1.5574644648686045 20.923697131152213 -9.995656804477553 5.003086004220215 0.9999931592183796 1.7243053369533317 0.862680348439466 0.13622500163961224 1.0394486219492642e-05 2.0864554031845413e-06 0.13190053591588993 0.04396643021955588 1.0100507501518997e-10 9.995656804477553 0.724312177734952 SYCNDQSTGDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYCNDQSTGDIK 12 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 11078100.0 4552100.0 3445400.0 3080600.0 False True 5892783.185305864 3253660.4612499876 2519962.4096252844 1.0 0.552143250300343 0.4276353516465728 22.49051775503883 -13.99999999999999 0.17959586418621096 3.3208576613692906 0.32831851710032356 0.9994986307203402 0.00550337004701044 12.19953325717015 0.1343399025184441 9.879161472224439 0.09328230875482477 1.0000000000000246e-14 13.99999999999999 -2.9925391442689673 SYCNDQSTGDIK(ub)VIGGDDLSTLTGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYCNDQSTGDIKVIGGDDLSTLTGK 25 1 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 1 73921700.0 2637700.0 13954000.0 57330000.0 True False 4001583.741700121 11463799.67690039 45998700.37136832 1.0 2.8648156372281384 11.495123766127962 21.932139670346274 -6.941544233244713 0.6450423302450734 0.9051183160318446 13.932083862868877 0.9983591861315912 0.18518735117040608 0.08706930680078967 0.051455152835157454 0.18244874707421013 0.737887417485129 1.1440783485763054e-07 6.941544233244713 13.026965546837033 SYCNDQSTGDIK(ub)VIGGDDLSTLTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYCNDQSTGDIKVIGGDDLSTLTGK 25 1 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 1 13354100.0 3072900.0 2069100.0 8212100.0 True False 2555252.502551806 2057953.3476158064 9929212.141539685 1.0 0.8053815994938381 3.885804683342983 21.28503443042052 -6.891842191403174 1.011458092097074 0.8417199984506298 4.160476296350105 0.9820501752983379 0.18870601970257841 0.1176597680755882 0.21323642196195638 0.1418052312763635 0.3559370553164654 1.28279662486668e-07 6.891842191403174 3.3187562978994753 up SYCNDQSTGDIK(ub)VIGGDDLSTLTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYCNDQSTGDIKVIGGDDLSTLTGK 25 1 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 1 90853700.0 2637700.0 11527000.0 76689000.0 True False 3414554.6468402073 10885512.316952646 62732388.895589635 1.0 3.187974258085453 18.372055914712487 21.703265992438723 -6.9328398921752985 0.7231034199156855 0.7916645074963066 21.72734351924382 0.9970675061390927 0.4183480715604586 0.09118988751651359 0.07065184740269805 0.38778913777631413 1.3530838465372692 1.167239854601379e-07 6.9328398921752985 20.935679011747514 SYCYVSK(ub)EELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYCYVSKEELK 11 1 Q13907;Q13907-2 Q13907 IDI1 Isopentenyl-diphosphate Delta-isomerase 1 1 12002000.0 0.0 0.0 12002000.0 True False 0.0 0.0 9629799.439336514 0.0 SYDVPPPPMEPDHPFYSNISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYDVPPPPMEPDHPFYSNISK 21 0 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 0 37725700.0 2998700.0 21490000.0 13237000.0 False True 3931324.73945211 18283775.76736393 11867362.218269954 1.0 4.650792539186689 3.0186674988146236 21.906584109032973 -9.104389592329094 10.877390007304966 0.9999755107284576 3.8347300190009626 0.800880999292365 0.6663122577062935 0.0 0.0 0.645154069299296 0.2150513564330986 7.863400715169178e-10 9.104389592329094 2.834754508272505 SYDVPPPPMEPDHPFYSNISK ddPTM_RPMI8226_Bortezomib_2h_R1 2 SYDVPPPPMEPDHPFYSNISK 21 0 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 0 56583700.0 18644800.0 9613200.0 28325700.0 False True 18052931.02964755 13451800.892175745 20906349.417214833 1.0 0.7451311296810713 1.1580584550442936 24.1057297527726 -6.739712620029648 1.687605311446282 0.8483068390603846 1.1582929599386262 0.6037387352703163 0.10708567943583513 0.31832347786069587 1.779958321616365 0.050199473198172744 0.12323069133216395 1.8209053837875108e-07 6.739712620029648 0.3099861208782416 SYDVPPPPMEPDHPFYSNISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYDVPPPPMEPDHPFYSNISK 21 0 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 0 31091700.0 2998700.0 14694000.0 13399000.0 False True 4107400.4268204523 14044770.493439918 10234432.161067147 1.0 3.41938185566972 2.4917054821922107 21.969794170555865 -10.339256637698385 6.0625703297081435 0.9998070414090079 2.955543668930966 0.8555935134596275 0.3787222935759145 0.0009878331253408 0.00010766012483266966 0.36672977920943356 0.12223209465474867 4.57871236841377e-11 10.339256637698385 1.9557366275219583 SYDVPPPPMEPDHPFYSNISK(ub)DR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYDVPPPPMEPDHPFYSNISKDR 23 1 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 1 9978900.0 2976100.0 4013000.0 2989800.0 True False 3901695.9205933996 3414276.042551481 2680444.176186711 1.0 0.8750748679646496 0.6869946379058286 21.895669914942477 -6.965195874970551 0.35467514483205487 1.0172253598674994 0.5384518047797074 0.9999171238108032 0.001171150525090312 0.07789455015844926 0.014625962368026438 0.0025526245056473407 0.01611713146010837 1.0834381528474619e-07 6.965195874970551 -0.47877355508779196 SYDVPPPPMEPDHPFYSNISK(ub)DR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYDVPPPPMEPDHPFYSNISKDR 23 1 P18669;Q8N0Y7 P18669 PGAM1;PGAM4 Phosphoglycerate mutase 1;Probable phosphoglycerate mutase 4 1 14111600.0 4144300.0 4878600.0 5088700.0 True False 4012741.4649751256 6826650.421562905 3755816.812272284 1.0 1.7012435217042379 0.9359727869474307 21.9361567777188 -6.6657343758954815 1.9528092190622504 1.4492452127319606 0.9391396697016389 0.2601292867281467 0.298171522194552 0.4710058576016734 3.45868659462453 0.12311344074706705 0.33073089836436975 2.1590645369953323e-07 6.6657343758954815 -0.5101055430303217 SYEAQDPEIASLSGK(ub)LK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYEAQDPEIASLSGKLK 17 1 U3KQ85;Q99622;F5GXW5 U3KQ85 C12orf57 Protein C10 1 20585100.0 6262200.0 4536000.0 9786900.0 True False 6063409.888754979 6347248.454927505 7223417.289293468 1.0 1.0468117068415455 1.1913127137734503 22.531697921778832 -6.950807931174176 0.5499099312737328 0.9980005257141247 1.246911199583134 0.9992631162796628 0.002210363053088197 0.0831630733320581 0.034633284259330856 0.002399353241249348 0.011987357862003485 1.119933069752588e-07 6.950807931174176 0.24891067386900922 SYEAQDPEIASLSGK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYEAQDPEIASLSGKLK 17 1 U3KQ85;Q99622;F5GXW5 U3KQ85 C12orf57 Protein C10 1 17716300.0 6262200.0 6018000.0 5436100.0 True False 5207296.762497942 5985579.83952053 6572763.3763134675 1.0 1.1494600965759527 1.2622217776504274 22.31210319721311 -6.974238664582064 0.11936165141266367 0.7951215364121533 1.619456384482712 0.9999994572860016 7.891006880591045e-05 0.0749497866963355 0.0035527081349029585 0.008002475832666707 0.016312549744929756 1.0611122674602697e-07 6.974238664582064 0.8243348480705586 SYEAQDPEIASLSGKLK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYEAQDPEIASLSGKLK 17 1 U3KQ85;Q99622;F5GXW5 U3KQ85 C12orf57 Protein C10 1 75347600.0 8500600.0 14791000.0 52056000.0 True False 11004194.271876963 13967867.847666062 42582342.13966557 1.0 1.2693221786681155 3.869646526369657 23.391550179043676 -6.926775379307249 0.7728051064054307 0.9553720684014574 4.3621320169281255 0.9958656168568653 0.08320082867868539 0.09434701357840664 0.08613944782644262 0.07439361376645852 0.23959141307260692 1.1836535928498633e-07 6.926775379307249 3.406759948526668 up SYELLK(ub)PPPICPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYELLKPPPICPR 13 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-9;Q9UKT9-10;Q9UKT9-11;Q9UKT9-16;Q9UKT9-12 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 17319300.0 1015500.0 4757800.0 11546000.0 True False 983263.5083565974 6657614.351599233 8521756.22742465 1.0 6.770936066494126 8.66680819027618 19.907218575900146 -9.036408222663262 0.4397410666349647 6.046819524733344e-23 8.860621430631948 0.9972748694169172 0.1702073880856877 0.487651800170042 0.16673159161872206 1.3964076133030665 0.43211136409362216 9.19584785643902e-10 9.036408222663262 8.860621430631948 SYELLK(ub)PPPICPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYELLKPPPICPR 13 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-9;Q9UKT9-10;Q9UKT9-11;Q9UKT9-16;Q9UKT9-12 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 16745700.0 1015500.0 2474200.0 13256000.0 True False 844433.2442778357 2460870.99350975 16027768.311181054 1.0 2.9142279868603485 18.980503692613496 19.687623851334422 -6.929215511845638 0.7532143374993058 0.7484305826186849 22.213773073632805 0.9963815963605519 0.4850068197694212 0.09304741403207326 0.07969380801798706 0.4398183003296114 1.4600450284759674 1.1770217499384169e-07 6.929215511845638 21.46534249101412 SYELLK(ub)PPPICPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYELLKPPPICPR 13 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-9;Q9UKT9-10;Q9UKT9-11;Q9UKT9-16;Q9UKT9-12 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 21463400.0 4374100.0 3354300.0 13735000.0 True False 5662358.676401306 3167630.256333326 11235370.933001125 1.0 0.5594188636503866 1.9842209890069573 22.43297170752511 -6.823658494346485 1.3559251584903427 0.763364619698685 2.017846550053535 0.8925980746341425 0.19519782504968355 0.18877197347300517 0.6809315685348081 0.11309522116962444 0.2604530898596673 1.5008645701934584e-07 6.823658494346485 1.2544819303548502 SYELPDGQVITIGNER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYELPDGQVITIGNER 16 0 P60709;A0A2R8Y793;P63267-2;A0A2R8YEA7;Q9BYX7;P63261;P68133;P68032;P63267;P62736;Q562R1;Q6S8J3;A5A3E0 P60709;P63261;P68133;Q562R1;Q6S8J3 ACTB;ACTG2;POTEKP;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2;POTEE;POTEF Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2;POTE ankyrin domain family member E;POTE ankyrin domain family member F 0 757820000.0 177180000.0 310260000.0 270380000.0 False True 232284695.813561 263970417.38400766 242403671.2680994 1.0 1.136408993539026 1.0435628159620993 27.791318863735434 -10.58580355980014 6.105687052259182 0.999733801467667 1.0899859047493796 0.55603855175716 0.037904293271884944 0.00013775976560176685 9.345328068522199e-06 0.03680874637564231 0.012233558049314277 2.5953530274598247e-11 10.58580355980014 0.09025210328171263 SYELPDGQVITIGNER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYELPDGQVITIGNER 16 0 P60709;A0A2R8Y793;P63267-2;A0A2R8YEA7;Q9BYX7;P63261;P68133;P68032;P63267;P62736;Q562R1;Q6S8J3;A5A3E0 P60709;P63261;P68133;Q562R1;Q6S8J3 ACTB;ACTG2;POTEKP;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2;POTEE;POTEF Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2;POTE ankyrin domain family member E;POTE ankyrin domain family member F 0 819480000.0 282620000.0 120360000.0 416500000.0 False True 273648382.7983668 168420375.66910824 307406155.26783 1.0 0.6154627114796654 1.1233618562779415 28.027748089659756 -6.704206096990491 1.815659326185827 0.7622133447968077 1.1219874863575023 0.4376711989765576 0.1621959592555425 0.38682865305875574 2.481978884516996 0.07118644963780021 0.18214251871743173 1.9760316801628222e-07 6.704206096990491 0.35977414156069465 SYELPDGQVITIGNER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYELPDGQVITIGNER 16 0 P60709;A0A2R8Y793;P63267-2;A0A2R8YEA7;Q9BYX7;P63261;P68133;P68032;P63267;P62736;Q562R1;Q6S8J3;A5A3E0 P60709;P63261;P68133;Q562R1;Q6S8J3 ACTB;ACTG2;POTEKP;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2;POTEE;POTEF Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2;POTE ankyrin domain family member E;POTE ankyrin domain family member F 0 2189544800.0 177767800.0 1833100000.0 178677000.0 False True 269686749.1670008 1505968982.9243271 143361412.63308886 1.0 5.584141555252206 0.5315849335419657 28.006709396798872 -6.667852055159226 1.9451643334414481 3.9314575137032275 0.5522880839459564 0.26949349030490455 1.9482189793377727 0.46606978312165964 3.3977284156467746 0.8069491609189284 2.161883249657264 2.1485622692150382e-07 6.667852055159226 -3.379169429757271 SYELPDGQVITIGNER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYELPDGQVITIGNER 16 0 P60709;A0A2R8Y793;P63267-2;A0A2R8YEA7;Q9BYX7;P63261;P68133;P68032;P63267;P62736;Q562R1;Q6S8J3;A5A3E0 P60709;P63261;P68133;Q562R1;Q6S8J3 ACTB;ACTG2;POTEKP;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2;POTEE;POTEF Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2;POTE ankyrin domain family member E;POTE ankyrin domain family member F 0 809420000.0 177180000.0 305250000.0 326990000.0 False True 242688234.1094635 291763045.67323667 249761696.57044187 1.0 1.2022133942498348 1.029146293337764 27.854528925258325 -10.729933680599949 2.926324063802317 0.9812559696923304 1.1156798438273974 0.373314419842531 0.07065434867441432 52662010.23677852 39596554.650297426 7107217.08275419 0.025856846707578665 1.8623715103687272e-11 10.729933680599949 0.13442387413506696 SYELPDGQVITIGNER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYELPDGQVITIGNER 16 0 P60709;A0A2R8Y793;P63267-2;A0A2R8YEA7;Q9BYX7;P63261;P68133;P68032;P63267;P62736;Q562R1;Q6S8J3;A5A3E0 P60709;P63261;P68133;Q562R1;Q6S8J3 ACTB;ACTG2;POTEKP;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2;POTEE;POTEF Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2;POTE ankyrin domain family member E;POTE ankyrin domain family member F 0 459562000.0 282620000.0 100870000.0 76072000.0 False True 235011052.1888743 100326593.28887275 91978303.4828126 1.0 0.42690159613532563 0.3913786293288506 27.808153365094032 -13.952046452358541 0.39575238823612946 9.999999877352591 0.3890587672743917 0.9998308512980157 0.0036274371739472744 25.118637033464818 0.20666150251008533 193.52762064085587 0.00920139161832724 1.1167437939084019e-14 13.952046452358541 -9.6109411100782 SYELPDGQVITIGNER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYELPDGQVITIGNER 16 0 P60709;A0A2R8Y793;P63267-2;A0A2R8YEA7;Q9BYX7;P63261;P68133;P68032;P63267;P62736;Q562R1;Q6S8J3;A5A3E0 P60709;P63261;P68133;Q562R1;Q6S8J3 ACTB;ACTG2;POTEKP;ACTG1;ACTA1;ACTC1;ACTA2;ACTBL2;POTEE;POTEF Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, gamma-enteric smooth muscle;Putative beta-actin-like protein 3;Putative beta-actin-like protein 3, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed;Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, aortic smooth muscle;Beta-actin-like protein 2;POTE ankyrin domain family member E;POTE ankyrin domain family member F 0 540497800.0 177767800.0 193150000.0 169580000.0 False True 230123921.42721307 182401032.70750415 138718180.03773797 1.0 0.7926209130118469 0.6027977412231512 27.77783571889132 -6.9721823266340355 0.19928307524761504 1.1140378118096703 0.27614389867468386 0.9999947740796967 0.0003707713649696235 0.07560075882248965 0.006428903831743328 0.006199457706858083 0.020188758402244295 1.0661484340657685e-07 6.9721823266340355 -0.8378939131349865 SYEPLEDPGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYEPLEDPGVK 11 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 28619400.0 2170400.0 16832000.0 9617000.0 False True 2845415.4181834995 14320731.210622132 8621925.092777988 1.0 5.032914040988933 3.0301111878708333 21.440207864387464 -9.72549376153708 8.647502424154931 0.999851486984624 4.031512614429884 0.7533779864709085 0.8176408454174964 0.0 0.0 0.7916773423387723 0.2638924474462574 1.8815087331290146e-10 9.72549376153708 3.0316611274452603 SYEPLEDPGVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYEPLEDPGVK 11 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 23850700.0 6860200.0 5221500.0 11769000.0 False True 6642426.706083635 7306472.179762777 8686345.837568047 1.0 1.0999703125171045 1.3077066894260854 22.663278973130954 -6.959289873078545 0.44532951697968604 0.9929717476032052 1.4228766789111038 0.9997429447797779 0.002054822365696406 0.07995578809497197 0.02207606752908169 0.002758078320465728 0.017195902422190625 1.098272544568685e-07 6.959289873078545 0.42990493130789864 SYEPLEDPGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYEPLEDPGVK 11 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 29775400.0 2170400.0 16476000.0 11129000.0 False True 2972855.5328546073 15748035.841153951 8500559.408949643 1.0 5.297275857206659 2.8593920272967996 21.503417925910355 -9.655153705086306 8.616121169711656 1.0000326100409438 4.0783339422517315 0.6800928111860418 0.9952619060882818 0.0 0.0 0.9636581967681733 0.3212193989227244 2.2123115918379172e-10 9.655153705086306 3.0783013322107875 SYEPLEDPGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYEPLEDPGVK 11 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 19785700.0 6286600.0 6917900.0 6581200.0 False True 8138127.627412369 6532912.783677169 5383489.12881448 1.0 0.8027537884355348 0.6615144631893953 22.956265475195504 -6.974739137198253 0.08969363704876253 1.4160094881817162 0.04469711428430242 0.9999998367145096 5.579538491723732e-05 0.07479279807618591 0.0026159908893641855 0.01469235039042589 0.02509793164613701 1.0598901663701523e-07 6.974739137198253 -1.3713123738974138 SYEPLEDPGVKSVTK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYEPLEDPGVKSVTK 15 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 21528700.0 6528900.0 8680900.0 6318900.0 True False 8559451.125957545 7385743.55788318 5665080.84316885 1.0 0.8628758373869373 0.6618509481278332 23.029086856225423 -6.96563544048085 0.3469746796295613 1.0201154769948697 0.49785939385453615 0.9999256485819383 0.0011974066725838424 0.07774599983280248 0.014103386362969955 0.002781343581720666 0.01731387847291567 1.0823421197764352e-07 6.96563544048085 -0.5222560831403336 SYEPLEDPGVKSVTK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYEPLEDPGVKSVTK 15 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 55613000.0 13091000.0 15108000.0 27414000.0 True False 19860004.080295824 12411859.36065724 21995610.88401698 1.0 0.6249676138270138 1.1075330495948894 24.243362583483762 -6.699261782440896 1.8333521263800476 0.766953335466757 1.1060847339741746 0.4141315451395845 0.15832716615422057 0.39706641633015666 2.594125917166414 0.06890692766753088 0.17738198169926372 1.998656763443674e-07 6.699261782440896 0.3391313985074176 SYEPLEDPGVKSVTK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYEPLEDPGVKSVTK 15 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 20262000.0 6528900.0 8108600.0 5624500.0 True False 8942810.76688834 7750335.240445558 4296108.940213611 1.0 0.8666553997924185 0.48039805964813537 23.092296917748314 -6.952236281220375 0.5337344515124001 1.0059331314360045 0.3234735173225535 0.9993652607937539 0.005551340353666665 0.08260011049502106 0.03234152052354174 0.006159786793489805 0.03195748763476483 1.1162557750898662e-07 6.952236281220375 -0.6824596141134509 down SYEPLEDPGVKSVTK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYEPLEDPGVKSVTK 15 1 P37837;F2Z393 P37837 TALDO1 Transaldolase 1 57583000.0 13091000.0 16660000.0 27832000.0 True False 16946557.56218871 15732856.354683006 22766861.58043591 1.0 0.9283806635623907 1.3434505206670118 24.01448890557621 -6.8624166281105365 1.1733674498455724 0.9608599909111644 1.3645073961091065 0.9565164911278423 0.037776754706409364 0.14433856451257415 0.37623539827175034 0.025083617169619758 0.05872513271281412 1.3727244588232295e-07 6.8624166281105365 0.4036474051979422 SYEQLK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYEQLKEK 8 1 A0A590UJQ1;Q96J02-3;Q96J02-2;Q96J02;A0A590UK44;A0A590UJW8;Q9H0M0-6;Q9H0M0-3;Q9H0M0 A0A590UJQ1;Q9H0M0-6 ITCH;WWP1 E3 ubiquitin-protein ligase Itchy homolog;NEDD4-like E3 ubiquitin-protein ligase WWP1 1 4429970.0 585280.0 602690.0 3242000.0 True False 757656.4975935977 569149.7716929115 2651989.2657291335 1.0 0.7511976383764875 3.500252784939019 19.531184389402323 -6.884799131878934 1.0526924091369503 0.8333532714669925 3.7139151827039827 0.9773539810232502 0.18681867165743202 0.12346302050244444 0.24732816859011683 0.1360640913427481 0.33343341505000784 1.303769653270268e-07 6.884799131878934 2.88056191123699 up SYETVLSFGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYETVLSFGKR 11 1 E5RGS2;Q9H6H4;Q9H6H4-2 E5RGS2 REEP4 Receptor expression-enhancing protein;Receptor expression-enhancing protein 4 1 13880300.0 4734100.0 4514800.0 4631400.0 True False 6206450.945089617 3841209.4385525673 4152187.155525832 1.0 0.618905953263295 0.6690115159632309 22.56533709258612 -10.023457114684701 4.8926708252837745 1.0000059374156272 0.6439587346083577 0.9853637740180349 0.020455510333273322 28261788.37681095 6.988061167239897 1890.4031336053665 0.007002465268990642 9.474207349236723e-11 10.023457114684701 -0.3560472028072694 SYETVLSFGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYETVLSFGKR 11 1 E5RGS2;Q9H6H4;Q9H6H4-2 E5RGS2 REEP4 Receptor expression-enhancing protein;Receptor expression-enhancing protein 4 1 14987400.0 4880200.0 5657200.0 4450000.0 True False 4725280.722286419 7916149.461908261 3284411.5028615706 1.0 1.6752760157872437 0.6950722498603944 22.171968609688594 -6.721353447916861 1.7544258853601116 1.4102485181839206 0.6964894692502368 0.5188096092841847 0.28411474424581357 0.3527451886518839 2.1226322774400583 0.12854644395747322 0.3221894468598826 1.899531728364324e-07 6.721353447916861 -0.7137590489336838 SYETVLSFGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYETVLSFGKR 11 1 E5RGS2;Q9H6H4;Q9H6H4-2 E5RGS2 REEP4 Receptor expression-enhancing protein;Receptor expression-enhancing protein 4 1 12975500.0 4734100.0 5500000.0 2741400.0 True False 6484424.704242073 5256991.813932188 2093937.7809052505 1.0 0.8107105955742063 0.32291805000610285 22.62854715410901 -6.954808812629049 0.503294265382343 1.0094961597730712 0.10297546780687081 0.9995266044371033 0.006205961455331855 0.08161037397707072 0.02840168734363579 0.0072336834570073845 0.04024364267661631 1.1096632094503727e-07 6.954808812629049 -0.9065206919662003 down SYETVLSFGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYETVLSFGKR 11 1 E5RGS2;Q9H6H4;Q9H6H4-2 E5RGS2 REEP4 Receptor expression-enhancing protein;Receptor expression-enhancing protein 4 1 15200500.0 4880200.0 7575100.0 2745200.0 True False 4058102.5295171705 7534291.432760374 3319208.62762932 1.0 1.856604503695671 0.8179213323188846 21.95237388512287 -6.687614205659402 1.8746526021536045 1.538220275767597 0.8215854501717156 0.35941281504161016 0.3624587750403287 0.42180414794019183 2.87206434103827 0.15477521367818425 0.4042975076519558 2.0529850855736828e-07 6.687614205659402 -0.7166348255958813 SYFK(ub)SISVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYFKSISVTK 10 1 O00165-5;O00165-3;O00165;O00165-2;E9PIQ7;Q5VYD6 O00165-5 HAX1 HCLS1-associated protein X-1 1 16189300.0 1012300.0 2642000.0 12535000.0 True False 980165.0906050057 3696964.377847991 9251707.458060624 1.0 3.77177723761417 9.438927734459527 19.902665239315578 -6.959611258660701 0.44087856603851255 0.7992129946546157 12.632768458458859 0.9997555080851688 0.05491633207510121 0.0798402815776135 0.02164665394021874 0.07480032144204975 0.4694814290365554 1.0974601041477636e-07 6.959611258660701 11.833555463804244 SYFK(ub)SISVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYFKSISVTK 10 1 O00165-5;O00165-3;O00165;O00165-2;E9PIQ7;Q5VYD6 O00165-5 HAX1 HCLS1-associated protein X-1 1 35058900.0 2289900.0 16058000.0 16711000.0 True False 3473945.714114231 13192324.438273352 13408063.525308503 1.0 3.79750448738289 3.8596065191327327 21.728143779161165 -10.39375631961227 0.7495281841007604 6.91190319904297e-16 3.847551882357474 0.9999414331836507 0.010206167181358014 1.7634453653526099 0.38763089110059834 3.5862101255188374 0.0092770218753975 4.0387193986124386e-11 10.39375631961227 3.847551882357473 SYFK(ub)SISVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYFKSISVTK 10 1 O00165-5;O00165-3;O00165;O00165-2;E9PIQ7;Q5VYD6 O00165-5 HAX1 HCLS1-associated protein X-1 1 8820400.0 1012300.0 3749900.0 4058200.0 True False 841772.3024937989 3729698.5444031246 4906750.857003246 1.0 4.430768906690893 5.829071403830602 19.683070514749854 -9.005063791053056 0.3520785083164163 2.42317390568581e-20 6.229109350687265 0.998054469127113 0.08948797751843668 0.46624828710540517 0.12555278765382663 1.062444394044663 0.3999166564308345 9.884079023636006e-10 9.005063791053056 6.229109350687265 SYFLIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYFLIVR 7 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 30936900.0 9431000.0 8844900.0 12661000.0 False True 12364132.329933926 7525275.39715016 11350961.172887798 1.0 0.6086375652039284 0.9180556200783122 23.559657664374225 -9.861714382575704 6.271489171734876 1.0000000171936008 0.7633465926410633 0.438189976812446 0.1263193919413248 3.030869733156492e-08 5.521521497433551e-09 0.1223082344355254 0.04076940844095323 1.3749459225033628e-10 9.861714382575704 -0.23665342455253746 SYFLIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYFLIVR 7 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 24288300.0 9370300.0 4752000.0 10166000.0 False True 9072844.955542892 6649498.381352623 7503219.626537242 1.0 0.7329011367366342 0.8269974482428782 23.11312357428755 -10.879622145554384 10.466572611583132 1.012094257608478 0.7799492924897562 0.8793999785670795 0.038414658311379274 0.010543083104087954 0.00012125758698214142 0.036171579651013676 0.012398277657518355 1.3194041763911026e-11 10.879622145554384 -0.23214496511872174 SYFLIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYFLIVR 7 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 20535700.0 4744600.0 7500700.0 8290400.0 False True 7197905.076722288 6162141.481763415 6651798.806188605 1.0 0.85610207637935 0.9241298315672755 22.77914564599012 -10.178436427210643 4.683850971483793 1.0000155902486574 0.8901159539724935 0.7767284085951263 0.02777221476237308 4.521982703963641e-06 7.931754936425295e-07 0.026894145478967357 0.008963443771433178 6.630764028558772e-11 10.178436427210643 -0.10989963627616384 SYFLIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYFLIVR 7 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 25385400.0 9431000.0 6494700.0 9459700.0 False True 12917895.56319195 6207742.678899162 7225513.688636984 1.0 0.48055371314406714 0.5593413922020898 23.622867725897116 -10.704574655423778 6.811954373464876 1.004665140375269 0.5199475526731673 0.9801977644061534 0.032164935285053244 0.0022887576650094097 9.926023668007138e-05 0.03127858806136549 0.010381188224237548 1.9743554576137624e-11 10.704574655423778 -0.4847175877021018 SYFLIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYFLIVR 7 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 17544300.0 9370300.0 3801600.0 4372400.0 False True 7791819.624674139 3781120.02624148 5286648.624306582 1.0 0.48526791024113447 0.6784870388382065 22.893528849721825 -10.106333876523212 5.171047579717832 1.0000100026142362 0.5818774745390431 0.8619499897755242 0.07888137893686115 9.096597410767583e-06 1.572183167852105e-06 0.07637839343612422 0.025458855578713493 7.828275898789121e-11 10.106333876523212 -0.4181325280751931 SYFLIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYFLIVR 7 0 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 0 25674400.0 4744600.0 11521000.0 9408800.0 False True 6141978.23004816 10879846.222227056 7696494.9424405545 1.0 1.7713912056867946 1.2530970729898216 22.55027196808257 -10.173250815149803 4.469118423299363 0.999897782178921 1.5122441393497907 0.5656682059683433 0.21159269367269076 23998885.743660595 54629757.77022127 14786.484649580816 0.07243380819993916 6.710411991197426e-11 10.173250815149803 0.5123463571708697 SYGANFSWNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYGANFSWNK 10 0 O43181 O43181 NDUFS4 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial 0 12546900.0 3979300.0 3289700.0 5277900.0 False True 5216900.835596016 2798889.5831501675 4731793.5371917365 1.0 0.5365042716650378 0.9070123596955707 22.31476157977368 -9.905183404358663 6.63695353234194 1.0000000150721537 0.7217583156802975 0.42920676286277193 0.15125929354152529 3.370984678019537e-08 5.589951172034086e-09 0.14645618994080634 0.0488187270704484 1.2439891590539848e-10 9.905183404358663 -0.2782416993918563 SYGANFSWNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYGANFSWNK 10 0 O43181 O43181 NDUFS4 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial 0 9383100.0 3979300.0 2016800.0 3387000.0 False True 5450554.746539039 1927691.107334263 2587060.357454615 1.0 0.35366879097183584 0.4746416608506376 22.377971641296572 -10.57508096999685 6.886548065036359 1.000694316100721 0.4141552259134774 0.9690114659337954 0.049386967320528156 0.0005270292083749928 3.251907013372811e-05 0.04786957771590803 0.01593957516267462 2.660229039640393e-11 10.57508096999685 -0.5865390901872435 SYGANFSWNKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYGANFSWNKR 11 1 O43181 O43181 NDUFS4 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial 0 7765900.0 3531000.0 1193700.0 3041200.0 False True 4629175.194252636 1015604.6130061566 2726525.7972503286 1.0 0.21939213151126424 0.5889873860543133 22.14232373275256 -10.669486800841415 6.619943919474902 1.0038648186554897 0.40418975879740066 0.7760352948047118 0.1508866308307561 0.00863250177372849 0.0004309936485302904 0.1465335405843038 0.04869845069773871 2.140489979952237e-11 10.669486800841415 -0.5996750598580891 SYGANFSWNKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYGANFSWNKR 11 1 O43181 O43181 NDUFS4 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial 0 5334920.0 3531000.0 875440.0 928480.0 False True 4836506.121687063 836760.1661070548 709192.1466458407 1.0 0.1730092229915709 0.1466331539343656 22.20553379427545 -13.034843679180128 0.5031504710015755 9.999999999959142 0.14803508732146312 0.999931106879663 0.003288616061609468 17.76918547649568 0.25110568975686837 174.77110764536718 0.005341330012054893 9.229035591203013e-14 13.034843679180128 -9.851964912637678 SYGANFSWNKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYGANFSWNKR 11 1 O43181 O43181 NDUFS4 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial 0 22541200.0 2032800.0 9858600.0 10649800.0 False True 2631499.6724785864 9309960.243594116 8711645.676175848 1.0 3.5378914696292347 3.310525084721149 21.327453784594326 -9.968546236318208 6.608033152110984 0.9999996348691587 3.424208277175219 0.9934458238801104 0.09282193794777191 5.06484352780096e-07 7.904035893762235e-08 0.08987446834797745 0.0299581516528539 1.0751121345751148e-10 9.968546236318208 2.42420864230606 SYGQDHLDTGLFPEK(ub)PR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYGQDHLDTGLFPEKPR 17 1 Q9Y289 Q9Y289 SLC5A6 Sodium-dependent multivitamin transporter 1 17103900.0 7077800.0 4952600.0 5073500.0 True False 9279064.341512704 4213691.385083598 4548542.888448492 1.0 0.4541073571644906 0.4901941317616699 23.14554790722932 -10.090974429618916 5.528016861940279 1.0000049819696064 0.47215074446291133 0.9965068444654094 0.014732364038248206 9.04577244074814e-07 1.487701340021089e-07 0.014264684633539618 0.004754850047447028 8.110088070070859e-11 10.090974429618916 -0.527854237506695 SYGQDHLDTGLFPEK(ub)PR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYGQDHLDTGLFPEKPR 17 1 Q9Y289 Q9Y289 SLC5A6 Sodium-dependent multivitamin transporter 1 12052700.0 1239500.0 6112900.0 4700300.0 True False 1200152.7509679964 8553812.848352375 3469150.424022528 1.0 7.127270125784574 2.8905907362412377 20.194786607690713 -9.847601303964838 8.271050133734482 1.000000105514063 5.008930431012904 0.5441773593239646 1.7296171180245519 4.054574554406541e-08 0.0 1.674694648220764 0.5582315244520294 1.4203608594223354e-10 9.847601303964838 4.008930325498841 SYGQDHLDTGLFPEK(ub)PR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYGQDHLDTGLFPEKPR 17 1 Q9Y289 Q9Y289 SLC5A6 Sodium-dependent multivitamin transporter 1 14637600.0 7077800.0 2160800.0 5399000.0 True False 9694653.930353088 2065328.7111899422 4123867.395895333 1.0 0.21303789965349706 0.425375410563535 23.208757968752213 -10.082285468468333 5.262634147574945 1.0000100790470081 0.31920665511446616 0.932001297888041 0.08668642583343426 1.0251324976119632e-05 1.7877214674154856e-06 0.08393501282064801 0.027977923632486877 8.273981233675918e-11 10.082285468468333 -0.680803423932542 SYGQDHLDTGLFPEK(ub)PR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYGQDHLDTGLFPEKPR 17 1 Q9Y289 Q9Y289 SLC5A6 Sodium-dependent multivitamin transporter 1 6544500.0 1239500.0 2327900.0 2977100.0 True False 1030699.1691603896 2315359.140648026 3599597.8454448613 1.0 2.2463966304873653 3.492384541628285 19.97519188312499 -6.971129307434415 0.22961722797258524 0.49082984229591503 5.283536583984521 0.9999899009623849 0.003233543653415858 0.07593795604865776 0.007706210992962648 0.03210566937928923 0.12384350670011225 1.0687366247384676e-07 6.971129307434415 4.7927067416886056 SYHLSELVQQILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYHLSELVQQILK 13 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 5855750.0 3008550.0 1047100.0 1800100.0 False True 3944238.184839645 890876.7615638319 1613842.9197784816 1.0 0.22586789129218143 0.40916467113511634 21.911315245206136 -10.747163807932234 10.28930664632309 1.001708374907304 0.31751628126816805 0.94867782030043 0.07483059701840925 0.002935115820710799 7.212364471832742e-05 0.07251693493576421 0.024151471336588116 1.7899305976252776e-11 10.747163807932234 -0.6841920936391359 SYHLSELVQQILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYHLSELVQQILK 13 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 18829700.0 3613100.0 2189100.0 13027500.0 False True 3498404.118210951 3063219.0460056914 9615206.93337732 1.0 0.8756046878804246 2.748455183700859 21.738265521152016 -6.891016452550076 1.0163254913211666 0.9018082469270187 2.9127977410762904 0.9815418041113328 0.1161691720705906 0.11832328034634468 0.2170493334555402 0.08697310155800726 0.21763925589644134 1.2852379698416792e-07 6.891016452550076 2.0109894941492716 up SYHLSELVQQILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYHLSELVQQILK 13 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 15157000.0 5621500.0 4843900.0 4691600.0 False True 8528226.486699482 3979468.1994365603 3764303.203598667 1.0 0.46662318427434946 0.4413934373658378 23.02381432202015 -13.76004434690559 0.43728150408077276 9.999999999998012 0.4410812476349068 0.9998812669031988 0.0028068049112977716 26.51428881353864 0.22278172133796953 227.6532549989834 0.005868808549120693 1.7376233865806992e-14 13.76004434690559 -9.558918752363105 SYHLSELVQQILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYHLSELVQQILK 13 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 15438250.0 3008550.0 4272600.0 8157100.0 False True 4120892.238006693 4083822.4044012097 6230560.980747877 1.0 0.9910044156788206 1.5119446520061506 21.974525306729028 -6.902974397568225 0.9422967794747087 0.9800727035322012 1.5700478650569614 0.9879880295047875 0.026685306506464036 0.10924863004227119 0.16534014442396272 0.021115410413488196 0.05580413358089618 1.2503327373827618e-07 6.902974397568225 0.5899751615247601 SYHLSELVQQILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYHLSELVQQILK 13 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 13239200.0 3613100.0 2031800.0 7594300.0 False True 3004452.7374694697 2020854.2901192775 9182233.017924124 1.0 0.672619763631683 3.056208175089468 21.518670796586292 -6.872199337494627 1.122452412542351 0.8121561780160522 3.2017292554504313 0.9668265442744107 0.19214790193258607 0.13476066444624368 0.3159960919067312 0.1326729925748964 0.3153513932583489 1.3421487847963378e-07 6.872199337494627 2.3895730774343793 up SYHLSELVQQILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYHLSELVQQILK 13 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 11230300.0 5621500.0 3215600.0 2393200.0 False True 7277142.566331357 3036649.0332604256 1957662.1563056621 1.0 0.41728590660156584 0.2690152265757496 22.7949406441126 -13.99999999999988 0.19218108974000445 4.147596173119557 0.1649475397041178 0.9994883562317696 0.007136529093994053 12.38708023142694 0.13902217477186182 14.611476428273242 0.1002270186646606 1.0000000000002782e-14 13.99999999999988 -3.9826486334154394 SYIEGYVPSQADVAVFEAVSSPPPADLCHALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYIEGYVPSQADVAVFEAVSSPPPADLCHALR 32 0 P24534;C9JZW3;F2Z2G2 P24534 EEF1B2 Elongation factor 1-beta 0 75782100.0 8038100.0 53516000.0 14228000.0 False True 12194385.36382443 43965651.67758349 11415829.56364606 1.0 3.6054012043945187 0.9361545681106638 23.539713707715936 -6.6517515905108855 2.0026111324485782 2.6883723171729788 0.9474719752153309 0.20098524106891902 1.1115526556229898 0.5043059203245117 3.878766997158304 0.4498763827147302 1.2310531117182537 2.229710143094112e-07 6.6517515905108855 -1.7409003419576479 SYIEYQLTPTNTNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYIEYQLTPTNTNR 14 0 Q9Y5X1 Q9Y5X1 SNX9 Sorting nexin-9 0 13318700.0 4317500.0 5040200.0 3961000.0 False True 5660284.31072948 4288221.806545721 3551153.716594948 1.0 0.7575983062223721 0.6273808030920776 22.432443089409247 -13.99999999950043 0.0766402446105115 2.3354105175708377 0.21314404910155926 0.9999001730988245 0.0015426738843437513 12.29216816677599 0.07690237532070679 2.8282541000050796 0.3778407760132628 1.0000000011503028e-14 13.99999999950043 -2.1222664684692782 SYIEYQLTPTNTNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYIEYQLTPTNTNR 14 0 Q9Y5X1 Q9Y5X1 SNX9 Sorting nexin-9 0 9794500.0 4317500.0 2446100.0 3030900.0 False True 5913796.426050392 2338023.2138290037 2315063.843344906 1.0 0.395350642022435 0.39146830167284813 22.49565315093214 SYIK(ub)LFQAPCQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYIKLFQAPCQR 12 1 Q6P2C8;Q6P2C8-2 Q6P2C8 MED27 Mediator of RNA polymerase II transcription subunit 27 1 5585190.0 998190.0 2315700.0 2271300.0 True False 1367247.8180704655 2213384.7170041394 1734865.7188918418 1.0 1.618861400069951 1.2688743737329045 20.382843329091838 -10.103139710097592 4.645451508430381 0.9999697372090312 1.443867886910406 0.6819925296615541 0.14288160521740353 4.478864861364632e-05 8.647073335547438e-06 0.13835393633260543 0.046114839786184254 7.886063865598724e-11 10.103139710097592 0.44389814970137487 SYIYSGSHDGHINYWDSETGENDSFAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYIYSGSHDGHINYWDSETGENDSFAGK 28 0 O75083;O75083-3 O75083 WDR1 WD repeat-containing protein 1 0 12908600.0 5140500.0 5023000.0 2745100.0 False True 6739245.280672811 4273587.979500646 2461063.3848585673 1.0 0.6341345063900082 0.3651838273221104 22.68415560423329 -7.87782268279284 0.19841356065115318 1.239750174136603 5.899377024822919e-10 0.9998758583069336 0.0028987503737558365 0.11831958645363017 0.03065308981503814 0.06566237939342458 0.09570642898878684 1.3248823582939478e-08 7.87782268279284 -1.2397501735466654 down SYIYSGSHDGHINYWDSETGENDSFAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYIYSGSHDGHINYWDSETGENDSFAGK 28 0 O75083;O75083-3 O75083 WDR1 WD repeat-containing protein 1 0 16571700.0 3566900.0 2654800.0 10350000.0 False True 3453670.7119223513 3714875.4845991028 7639024.506655564 1.0 1.0756310587963849 2.2118566429292263 21.719699105890147 -6.920406454912133 0.8217106696840777 0.9752955873295187 2.3968048718824915 0.9942930250406089 0.04187500067474361 0.09793309096630964 0.10438055364298979 0.036157485918724995 0.1087326055913969 1.2011397652832495e-07 6.920406454912133 1.4215092845529727 up SYK(ub)NSGVISVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYKNSGVISVK 11 1 O75131;H0YB26 O75131 CPNE3 Copine-3 1 3126030.0 791260.0 1647200.0 687570.0 True False 657967.748761477 1638326.206656398 831337.7080355126 1.0 2.489979500880241 1.263493096128766 19.327657344351437 -6.598067794616707 2.1976785440065623 2.003273148886137 1.2673594490461164 0.015110172836300229 0.6443267298072936 0.6462169034451026 5.895461279752838 0.24360829328315425 0.7171195526019052 2.523086880624599e-07 6.598067794616707 -0.7359136998400204 SYKPVFWSPSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYKPVFWSPSSR 12 1 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 7392300.0 1438700.0 3326900.0 2626700.0 False True 1970626.2694056053 3179906.5574129107 2006327.5585846035 1.0 1.613652779718631 1.018116722451775 20.910222763564636 -10.307179884320648 3.9191770799137173 0.9993941388173755 1.3158847507462823 0.27279517594958413 0.24312657741068464 86354323.19306321 460.29167820556444 474170.91536312475 0.08322869421778138 4.9296957417941116e-11 10.307179884320648 0.3164906119289068 SYKPVFWSPSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYKPVFWSPSSR 12 1 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 7434900.0 2767900.0 2839500.0 1827500.0 False True 2301631.4887608266 2824203.0499033793 2209621.800594701 1.0 1.2270439745434225 0.9600241443448174 21.134225433247906 -6.68146437278752 1.896891640696894 1.14346521635771 0.9610334473005252 0.3307720138761764 0.09619607535144102 0.4352634651843546 3.029332594571705 0.040675441347476055 0.10706976322685144 2.0822632160278277e-07 6.68146437278752 -0.18243176905718472 SYLFQLLQGLAFCHSHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYLFQLLQGLAFCHSHR 17 0 E7ESI2;G3V5T9;P24941-2;P24941 E7ESI2 CDK2 Cyclin-dependent kinase 2 0 250613000.0 59365000.0 107288000.0 83960000.0 False True 90061045.1628416 88141618.15502997 67365269.19902478 1.0 0.9786874890876397 0.747995640925774 26.424399884535077 -6.924935834820039 0.7872470582639172 1.0042430991384412 0.7062146725815478 0.9954459178503412 0.00770023933094681 0.09535389381452958 0.09119539388177812 0.006814351029330951 0.021484074867969365 1.1886778366062418e-07 6.924935834820039 -0.29802842655689343 SYLFQLLQGLAFCHSHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYLFQLLQGLAFCHSHR 17 0 E7ESI2;G3V5T9;P24941-2;P24941 E7ESI2 CDK2 Cyclin-dependent kinase 2 0 193610000.0 59365000.0 77971000.0 56274000.0 False True 76849162.7590964 73631845.30798246 46032709.42000032 1.0 0.958134645380595 0.5990007928167256 26.195526206627527 -6.9288213492727895 0.7564074001568335 1.005706970053537 0.5274384390597255 0.996301399122488 0.010945590387410975 0.09325464474582222 0.08071336801034239 0.009902894834415104 0.03270862006581868 1.1780904913976707e-07 6.9288213492727895 -0.4782685309938115 SYLK(ub)EFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYLKEFR 7 1 Q9NZ01;M0R2N5;Q9NZ01-2;M0R329 Q9NZ01 TECR Very-long-chain enoyl-CoA reductase 1 24885200.0 5519100.0 7430100.0 11936000.0 True False 7235593.547040431 6321558.042302961 10700977.218196744 1.0 0.8736751174875852 1.4789356462088388 22.786679937463163 -6.8522260521251805 1.2242103610940196 0.9324341783489967 1.504202851433296 0.9434921917912378 0.06197182361691971 0.15502701379620323 0.4459632868374065 0.03958635606330587 0.09175020319689788 1.405315860846172e-07 6.8522260521251805 0.5717686730842992 SYLK(ub)EFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYLKEFR 7 1 Q9NZ01;M0R2N5;Q9NZ01-2;M0R329 Q9NZ01 TECR Very-long-chain enoyl-CoA reductase 1 39725200.0 4255200.0 6863000.0 28607000.0 True False 4120121.005178723 9603431.690072203 21113968.508395746 1.0 2.330861564017493 5.124599127515155 21.974255278336475 -6.959087051365869 0.44811453965142417 0.9081512744421868 6.657713968492017 0.9997348273592743 0.027989158942740244 0.08002886466715528 0.022348541896914424 0.03723802900346668 0.23115453642631564 1.098785573286272e-07 6.959087051365869 5.74956269404983 SYLK(ub)EFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYLKEFR 7 1 Q9NZ01;M0R2N5;Q9NZ01-2;M0R329 Q9NZ01 TECR Very-long-chain enoyl-CoA reductase 1 68705000.0 4885000.0 21785000.0 42035000.0 True False 7410902.14133718 17897296.543018106 33726763.82540504 1.0 2.4149956647233264 4.550966020355462 22.82121774419163 -6.965151803848096 0.3554371546599762 0.8060783560330115 6.232564818677477 0.9999162408868154 0.013358276913391476 0.07790947918563651 0.01467849886351927 0.02893902205587242 0.18294958493044142 1.0835481030316545e-07 6.965151803848096 5.4264864626444655 SYLK(ub)EFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYLKEFR 7 1 Q9NZ01;M0R2N5;Q9NZ01-2;M0R329 Q9NZ01 TECR Very-long-chain enoyl-CoA reductase 1 20956000.0 5519100.0 3071900.0 12365000.0 True False 7559660.418069416 2936173.3005851414 9444641.665168682 1.0 0.38840015797098204 1.2493473440412357 22.849889998986054 -6.715934205314227 1.7741963798695204 0.6263015263628605 1.2476876056796118 0.49318453936235274 0.2574995540529446 0.3632600180429109 2.2324576860432046 0.11534778809286453 0.2909325082836557 1.9233830952669196e-07 6.715934205314227 0.6213860793167513 SYLK(ub)EFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYLKEFR 7 1 Q9NZ01;M0R2N5;Q9NZ01-2;M0R329 Q9NZ01 TECR Very-long-chain enoyl-CoA reductase 1 29699300.0 4255200.0 7764100.0 17680000.0 True False 3538387.3373225466 7722273.25224682 21376806.256916184 1.0 2.18242733654201 6.041398020910776 21.75466055377075 -6.9495434640267035 0.5638327819642956 0.9505060400564328 7.458963398564936 0.9991649725778201 0.062205056769546824 0.08366957183421163 0.03672496113251031 0.06637576458560644 0.32105901724892105 1.1231985547646868e-07 6.9495434640267035 6.508457358508504 SYLK(ub)EFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYLKEFR 7 1 Q9NZ01;M0R2N5;Q9NZ01-2;M0R329 Q9NZ01 TECR Very-long-chain enoyl-CoA reductase 1 58368000.0 4885000.0 18563000.0 34920000.0 True False 6323728.797745916 17529952.731811572 28564918.309457526 1.0 2.772091165272631 4.517100467629075 22.59234406628408 -6.971314763445734 0.22457514163893438 0.24035396544154394 7.098376750351709 0.9999909007830772 0.004331268073413524 0.07587839335026417 0.00748527073778476 0.04668583250079997 0.17519333436184562 1.06828034144089e-07 6.971314763445734 6.8580227849101645 SYLLSMGIANPVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYLLSMGIANPVTR 14 0 A0A3B3ISW7;Q86VN1-2;Q86VN1 A0A3B3ISW7 VPS36 Vacuolar protein-sorting-associated protein 36 0 7447800.0 2216500.0 2825400.0 2405900.0 False True 2905852.964616535 2403861.3333229413 2156960.547022412 1.0 0.827248096374402 0.7422813794389802 21.470530274158225 -13.999999999986949 0.09288549195958068 1.8741020180075494 0.5395575889020638 0.9998287076959728 0.0014033798941122419 12.138271040505295 0.08924561645447061 2.075257167748301 0.1816922494319258 1.0000000000300509e-14 13.999999999986949 -1.3345444291054855 SYLLSMGIANPVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYLLSMGIANPVTR 14 0 A0A3B3ISW7;Q86VN1-2;Q86VN1 A0A3B3ISW7 VPS36 Vacuolar protein-sorting-associated protein 36 0 8274600.0 2424100.0 1843800.0 4006700.0 False True 2347148.272385257 2580038.9552899813 2957225.071576511 1.0 1.099222825266191 1.2599225649137504 21.162477550971463 -6.963951184964822 0.37561818604973873 0.988402964586366 1.3763858773342166 0.9998898628299523 0.0011239357764965378 0.07831870628642051 0.0161260567759182 0.002101778882477986 0.013608269419722135 1.0865477455593946e-07 6.963951184964822 0.3879829127478506 SYLLSMGIANPVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYLLSMGIANPVTR 14 0 A0A3B3ISW7;Q86VN1-2;Q86VN1 A0A3B3ISW7 VPS36 Vacuolar protein-sorting-associated protein 36 0 8932300.0 2216500.0 2413200.0 4302600.0 False True 3035999.9486602647 2306576.8446147577 3286414.494828534 1.0 0.7597420565282325 1.0824817359693213 21.533740335681117 -6.707381422466131 1.8045432507165722 0.8519015804096929 1.0816665256572977 0.45266255155604884 0.10128577205828111 0.38035955544976635 2.412762863953363 0.04469427196330915 0.11390627719261856 1.9616366975693416e-07 6.707381422466131 0.22976494524760482 SYLMTNYESAPPSPQYK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYLMTNYESAPPSPQYKK 18 1 O75223;M0QZK8;B8ZZK2;H7BZK5 O75223 GGCT Gamma-glutamylcyclotransferase 1 36756000.0 18242000.0 18514000.0 0.0 True False 15169031.257623099 18414261.407258715 0.0 1.0 1.2139378642261514 0.0 23.854625617664006 -6.910626270838021 1.2772983183499322 1.1119033490021888 1.722778719632022e-21 0.9538295253307448 0.11368698023833457 0.12777769113202658 0.4178162853331155 0.07296314308075438 0.1438256272528085 1.2284959502497459e-07 6.910626270838021 -1.1119033490021888 down SYLSGGAGAAGGGGADPGNK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYLSGGAGAAGGGGADPGNKK 21 1 H0YJV7;P25490;H0YJU4 H0YJV7 YY1 Transcriptional repressor protein YY1 1 10717500.0 1364100.0 1698500.0 7654900.0 True False 1765854.3404309538 1603976.9818985055 6261786.745906828 1.0 0.9083291555673032 3.5460380862323273 20.751934914006668 -6.898849060510839 0.9685298683970232 0.8868436094990143 3.8165145892153705 0.9859845235266277 0.14471552059760762 0.11225693522556285 0.18224276185864027 0.11230397722880321 0.2905399844464271 1.2622661602524438e-07 6.898849060510839 2.9296709797163563 up SYLVQYMQFSGSLHTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYLVQYMQFSGSLHTK 16 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 10428300.0 2413900.0 1621400.0 6393000.0 False True 2337272.0658020545 2268833.4754892974 4718481.514111022 1.0 0.970718603403463 2.018798574265181 21.15639424744917 -6.9004759539850475 0.9582872138280042 0.9569918155715084 2.1298688080232253 0.9868006475428606 0.05598680987672585 0.11105474852614812 0.17546493751036915 0.04378011082996508 0.11417859560398136 1.2575464802680735e-07 6.9004759539850475 1.1728769924517168 up SYLYFTQFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYLYFTQFK 9 0 Q969H8;M0QYN0;M0QXF7 Q969H8 MYDGF Myeloid-derived growth factor 0 440370000.0 124650000.0 133480000.0 182240000.0 False True 163417357.1123172 113565304.30096476 163383552.9695184 1.0 0.6949402824016485 0.9997931422745041 27.283985984259186 -10.97536477155669 9.31748595562632 1.0899727228633533 0.8473667123380764 0.2505089114126259 0.12445565888611289 0.07882588572765122 0.0002084138914043525 0.04083601659871954 0.0401678911839322 1.0583644129116707e-11 10.97536477155669 -0.24260601052527697 SYLYFTQFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYLYFTQFK 9 0 Q969H8;M0QYN0;M0QXF7 Q969H8 MYDGF Myeloid-derived growth factor 0 455812000.0 163950000.0 66172000.0 225690000.0 False True 158745496.9916927 92594824.68242136 166575018.44512975 1.0 0.5832910314757901 1.0493212191955705 27.242140427771776 -6.670959971071435 1.934170829423792 0.7342358023942555 1.0474383990592904 0.2832670124701381 0.1769697476540824 0.458887226269359 3.3106205841445586 0.07363934844594142 0.19648554949913108 2.1332415249872358e-07 6.670959971071435 0.3132025966650349 SYLYFTQFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYLYFTQFK 9 0 Q969H8;M0QYN0;M0QXF7 Q969H8 MYDGF Myeloid-derived growth factor 0 285688000.0 82204000.0 88234000.0 115250000.0 False True 124709477.91739626 72487953.32461151 92470786.98413044 1.0 0.5812545648906117 0.7414896488090525 26.893995873222458 -10.052934656850322 4.997337945783142 1.000006264943405 0.661372106847637 0.8562149194169715 0.06541569908964821 4.566158073434965e-06 8.654065476583865e-07 0.06333965018053778 0.021112826095138072 8.852487927179572e-11 10.052934656850322 -0.3386341580957679 SYLYFTQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYLYFTQFK 9 0 Q969H8;M0QYN0;M0QXF7 Q969H8 MYDGF Myeloid-derived growth factor 0 421590000.0 124650000.0 127610000.0 169330000.0 False True 170736473.53959033 121971768.25016116 129337741.46081784 1.0 0.7143861280576255 0.7575284810531537 27.347196045782077 -10.109591070876714 4.923341971244408 1.0000109115510967 0.7359573045542029 0.9803704269649851 0.017612791861442694 24543335.06826611 0.06791717492890607 3035.976110314864 0.006029327126301641 7.769783705546313e-11 10.109591070876714 -0.26405360699689373 SYLYFTQFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYLYFTQFK 9 0 Q969H8;M0QYN0;M0QXF7 Q969H8 MYDGF Myeloid-derived growth factor 0 358281000.0 163950000.0 105320000.0 89011000.0 False True 136331689.21649528 104752620.25561683 107622788.55963616 1.0 0.7683658939285146 0.7894187270630142 27.022545703206053 -10.753873487243164 6.890602355152187 1.0044529099968968 0.778892310495771 0.9932464536286972 0.00859478313658042 0.0005968174702102833 2.131778984163897e-05 0.008447422229054412 0.0027739543293533618 1.7624893960567755e-11 10.753873487243164 -0.22556059950112584 SYLYFTQFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYLYFTQFK 9 0 Q969H8;M0QYN0;M0QXF7 Q969H8 MYDGF Myeloid-derived growth factor 0 342564000.0 82204000.0 151670000.0 108690000.0 False True 106414698.48309204 143229431.1713549 88909535.25357783 1.0 1.3459553352407634 0.8355005137537879 26.665122195314908 -6.724200918793883 1.744345121257623 1.2095309165306873 0.8361113144320144 0.532153455055304 0.14550992652115977 0.3472414405491987 2.0670581966140675 0.06618053134512104 0.1653135216852502 1.8871181047237344e-07 6.724200918793883 -0.373419602098673 SYLYQILQGIVFCHSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYLYQILQGIVFCHSR 16 0 P06493;A0A024QZP7;A0A087WZZ9;E5RIU6 P06493 CDK1;CDC2 Cyclin-dependent kinase 1 0 1674100000.0 548310000.0 654150000.0 471640000.0 False True 831826356.830418 537411821.6027222 378420147.27284443 1.0 0.6460625071444842 0.4549268536221579 29.63170715731485 -11.358215834058209 0.10289910459471167 2.088099281829751 2.2021111320297084e-11 0.9998697410927794 0.0025771803457334957 4.063804569742305 0.06673440784451566 1.3252656983257438 0.31120494017555145 4.3831281256432644e-12 11.358215834058209 -2.0880992818077297 SYNDELQFLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYNDELQFLEK 11 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 18899900.0 2909800.0 8475200.0 7514900.0 False True 3814775.978543285 7210733.196070856 6737330.236010949 1.0 1.8902114401025343 1.7661142551767024 21.863166907082743 -10.292238953832081 5.440631946711394 0.9998831985094088 1.8281628476396508 0.9834384557921204 0.05066246359746296 7.178711541637571e-05 9.338635825605976e-06 0.04906053070799133 0.016351239815884575 5.1022419149656356e-11 10.292238953832081 0.828279649130242 SYNDELQFLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYNDELQFLEK 11 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 17624700.0 2909800.0 9523800.0 5191100.0 False True 3985631.6943882853 9103007.02500498 3965069.094060427 1.0 2.283955900346208 0.9948408177411852 21.926376968605634 -6.647108415902703 2.0183647860087808 1.8350892646657653 1.0002187670100278 0.18234972862191623 0.5484056572331045 0.5158401816432381 4.024400250651106 0.22058173924566113 0.6075374610845259 2.25367654123035e-07 6.647108415902703 -0.8348704976557375 SYNK(ub)DLESAEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYNKDLESAEER 12 1 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 15108490.0 2950790.0 5820400.0 6337300.0 True False 3868514.2654910064 4952019.007741498 5681576.98767411 1.0 1.2800829124286475 1.4686715875281857 21.883348163248762 -7.9175865717502925 0.06401378609177093 6.96934473836102e-16 2.5752493651915347 0.9999985903162887 0.00022853698318465313 0.12208423211838396 0.009654410830227056 0.18045972176777114 0.2004733505077051 1.2089641654297213e-08 7.9175865717502925 2.575249365191534 SYNK(ub)DLESAEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYNKDLESAEER 12 1 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 23781380.0 5139800.0 5122680.0 13518900.0 True False 4976639.862384273 7168192.838423291 9977894.531693326 1.0 1.4403680066552096 2.0049460695580628 22.246740558599253 -6.9677347228371 0.30752010390961904 0.9104352180408749 2.5527609570926475 0.9999589319300604 0.002635853023418343 0.07704481705613857 0.011647604056425483 0.009034676218340719 0.05024571277514299 1.0771229444584273e-07 6.9677347228371 1.6423257390517727 SYNK(ub)DLESAEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYNKDLESAEER 12 1 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 56193900.0 10898200.0 17544400.0 27751300.0 True False 16533366.165142426 14413464.74497713 22266243.391173117 1.0 0.8717804106561965 1.3467459178468697 23.978877148996148 -6.834831378749162 1.306238144273283 0.9316832938463353 1.3608302948977111 0.9151853041342272 0.05842888824300368 0.1749250747705334 0.5820006632823413 0.03510219878826894 0.08078827325346676 1.4627449965790787e-07 6.834831378749162 0.4291470010513758 SYNK(ub)DLESAEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYNKDLESAEER 12 1 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 13312890.0 2950790.0 4208800.0 6153300.0 True False 4041776.805101381 4022841.299359599 4700017.2711914675 1.0 0.9953150540826791 1.1628591824415637 21.946558224771653 -6.900466602373135 0.9583041896471894 0.9931230287606853 1.1806139359292132 0.9867972771536394 0.008950983156572018 0.11106295999833452 0.1754852171844947 0.0069991302526852235 0.018253727660431072 1.2575735591598174e-07 6.900466602373135 0.1874909071685279 SYNK(ub)DLESAEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYNKDLESAEER 12 1 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 25767800.0 5139800.0 13463500.0 7164500.0 True False 4273971.43174713 13390969.453204492 8662563.825094808 1.0 3.1331443522846576 2.026818373363271 22.02714583403353 -9.698399645793273 10.114090962556444 1.000000019456173 2.5799813628239643 0.7311409474921688 0.45165568959041597 0.0 0.0 0.43731374100087683 0.14577124700029223 2.0026283236661314e-10 9.698399645793273 1.5799813433677914 SYNK(ub)DLESAEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYNKDLESAEER 12 1 O43242 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 58792900.0 10898200.0 18370600.0 29524100.0 True False 14107934.735638577 17348259.960944753 24151016.742848095 1.0 1.2296810472989126 1.711874714152123 23.750003471088597 -6.959085453840068 0.44814215365718846 0.984151571875753 1.9764604845616456 0.99973474570367 0.004831482258430618 0.08002952782821926 0.02235124873434806 0.006427465579495982 0.039896619456230124 1.0987896151095168e-07 6.959085453840068 0.9923089126858926 SYQDPSNAQFLESIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYQDPSNAQFLESIR 15 0 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 0 8318200.0 1717800.0 2971900.0 3628500.0 False True 2252052.4351988616 2528504.1043754653 3253057.6270297286 1.0 1.1227554318255437 1.4444857394017452 21.102808987826105 -6.954441857846234 0.5077456457587535 0.993967311383136 1.5873344890733851 0.9995053259946898 0.004168524030660594 0.08174966734233734 0.02894905204131553 0.004820220468944641 0.026549399230446094 1.1106012096244148e-07 6.954441857846234 0.5933671776902492 SYQDPSNAQFLESIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYQDPSNAQFLESIR 15 0 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 0 9687400.0 1717800.0 3428300.0 4541300.0 False True 2352917.081799501 3276826.370127955 3468738.4710093457 1.0 1.3926654685263502 1.474228946630142 21.166019049348996 -12.1609227363555 0.25313634044946837 9.395912924236254e-12 1.5087960629426151 0.9994001541995713 0.005070386128896521 5.633275457619056 0.14839906777011153 2.9599858720144976 0.03694270194187714 6.903626126467849e-13 12.1609227363555 1.5087960629332193 SYQFWDTQPVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYQFWDTQPVPK 12 0 P30419;P30419-2;B7Z8J4;K7EN82 P30419 NMT1 Glycylpeptide N-tetradecanoyltransferase 1 0 7381700.0 1688600.0 2949200.0 2743900.0 False True 2213770.95242566 2509190.8558915635 2459987.5493473536 1.0 1.1334464629876038 1.111220447920283 21.07807453087733 -10.037661353546438 4.382264701833931 0.9999926555034885 1.1223334554362951 0.9758413107779988 0.009073732713897342 6277118.181677912 0.1302844917239441 469.89724279552956 0.0031061800463904206 9.169352029133036e-11 10.037661353546438 0.12234079993280667 SYQFWDTQPVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYQFWDTQPVPK 12 0 P30419;P30419-2;B7Z8J4;K7EN82 P30419 NMT1 Glycylpeptide N-tetradecanoyltransferase 1 0 6350600.0 1675900.0 1427300.0 3247400.0 False True 1622699.4718412808 1997228.3332711735 2396808.5200882386 1.0 1.230806053695768 1.4770501634344988 20.629964403078855 -6.970302952640915 0.2508496616620723 0.9226659296190833 1.792410204717972 0.999984647853499 0.0007631964489287585 0.07620457221293897 0.00867794214624563 0.005460689388616443 0.023567530758159833 1.0707721016234188e-07 6.970302952640915 0.8697442750988886 SYQFWDTQPVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYQFWDTQPVPK 12 0 P30419;P30419-2;B7Z8J4;K7EN82 P30419 NMT1 Glycylpeptide N-tetradecanoyltransferase 1 0 4334900.0 1688600.0 2646300.0 0.0 False True 2312921.0526991733 2529377.7158561386 0.0 1.0 1.093585841550606 0.0 21.141284592400222 -6.963603426691499 1.1803947598838578 1.056330103672148 2.1597990440587555e-20 0.9759157628609405 0.07681018133051597 0.10237653979658069 0.2824415496143793 0.054340057616580055 0.10215363499008559 1.0874181395127633e-07 6.963603426691499 -1.056330103672148 down SYQLRPGTMIEWGNYWAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYQLRPGTMIEWGNYWAR 18 1 O75323-2;O75323;C9K068 O75323-2 GBAS Protein NipSnap homolog 2 0 12468500.0 4034500.0 2797400.0 5636600.0 False True 3906427.005873644 3914416.408248281 4160205.3656246136 1.0 1.0020451943329862 1.0649643163354627 21.89741822607216 -6.913816756429425 0.8693270413820501 0.998279087330541 1.0737964214053883 0.9922841606348516 0.0026487146204145495 0.10194824953662966 0.1254727531145821 0.002210319758319798 0.006275669140303255 1.2195040405000002e-07 6.913816756429425 0.07551733407484729 SYQLRPGTMIEWGNYWAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYQLRPGTMIEWGNYWAR 18 1 O75323-2;O75323;C9K068 O75323-2 GBAS Protein NipSnap homolog 2 0 10760200.0 4034500.0 2630200.0 4095500.0 False True 3354865.508654773 2616030.5905461735 4951850.114547529 1.0 0.7797721201632146 1.4760204549997333 21.677823501506435 -6.8216484161211355 1.3646851697905726 0.8814921852932204 1.4917699038666599 0.8881433892955254 0.09717972375009885 0.19134641205835295 0.699761843707522 0.055951944857505764 0.12890966999949502 1.5078272364755582e-07 6.8216484161211355 0.6102777185734395 SYSCQVTHEGSTVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYSCQVTHEGSTVEK 15 0 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CF74;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC6;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-6 chain C region;Ig lambda-1 chain C regions 0 489014000.0 68414000.0 232020000.0 188580000.0 False True 89691416.52211846 197403520.4068764 169067550.58709309 1.0 2.2009187507724937 1.88499141994708 26.418466589896788 -10.108399309686616 4.741248131031586 0.9999382035790622 2.0429550853722893 0.935612652355987 0.12897679276321736 8.425541741206428e-05 1.5844191957120324e-05 0.12488858303779672 0.04162708086217738 7.791134295170393e-11 10.108399309686616 1.043016881793227 SYSCQVTHEGSTVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYSCQVTHEGSTVEK 15 0 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CF74;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC6;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-6 chain C region;Ig lambda-1 chain C regions 0 211459000.0 104810000.0 51671000.0 54978000.0 False True 101482863.92009352 72303499.7607053 40577612.49535364 1.0 0.7124700364944004 0.3998469389600987 26.596660898089297 -6.970054543902241 0.2568843027877949 1.091176196195925 0.01190326699093304 0.9999828032093725 0.0010163179481579058 0.07628504783136801 0.00896700258456304 0.006659789581271984 0.029636468398656208 1.0713847394608786e-07 6.970054543902241 -1.0792729292049918 down SYSCQVTHEGSTVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYSCQVTHEGSTVEK 15 0 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CF74;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC6;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-6 chain C region;Ig lambda-1 chain C regions 0 1097929000.0 141890000.0 912310000.0 43729000.0 False True 215257503.54848176 749501152.5894362 35085943.98289844 1.0 3.481881654455908 0.16299521923516194 27.68148828774775 -6.706546552245405 1.8074514379600666 2.531179911096431 0.17154691271222203 0.44866451017968045 1.0464383352073394 0.38208692803465405 2.4309849077978423 0.4611028290478103 1.176377727260285 1.965411295856948e-07 6.706546552245405 -2.359632998384209 SYSCQVTHEGSTVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYSCQVTHEGSTVEK 15 0 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CF74;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC6;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-6 chain C region;Ig lambda-1 chain C regions 0 575504000.0 68414000.0 304760000.0 202330000.0 False True 93708504.61883298 291294695.4934496 154543821.1171517 1.0 3.1085193033259326 1.6491973887084355 26.48167665141968 -10.493027391216723 6.241304630414111 0.9990551924491828 2.378858346017059 0.5434526201615498 0.5957656768790449 0.007836438579545028 0.0006365425484179823 0.5771358136520247 0.19228254539954415 3.2134578575101524e-11 10.493027391216723 1.3798031535678763 SYSCQVTHEGSTVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYSCQVTHEGSTVEK 15 0 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CF74;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC6;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-6 chain C region;Ig lambda-1 chain C regions 0 165119000.0 104810000.0 21336000.0 38973000.0 False True 87154158.87027076 21221058.733135574 47122074.10920781 1.0 0.24348876758392204 0.5406749915325231 26.377066173523573 -10.45391877525837 6.085347237678312 1.0002889024442656 0.3920818795621878 0.8480057283642185 0.12132576787642742 0.0004757627722345935 4.269376462685698e-05 0.11752705604913466 0.03915772320426914 3.5162619792937084e-11 10.45391877525837 -0.6082070228820777 SYSCQVTHEGSTVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYSCQVTHEGSTVEK 15 0 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CF74;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC6;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-6 chain C region;Ig lambda-1 chain C regions 0 291832000.0 141890000.0 100180000.0 49762000.0 False True 183679402.0700448 94604894.9347024 40705826.60123786 1.0 0.5150544583035256 0.22161345334581933 27.4526146098402 -8.553920123523898 0.2496576561665872 1.2442467537299442 1.0645135527862896e-23 0.9993290839503542 0.008313642467449879 0.18769346156721486 0.06774856611331653 0.14380282821067594 0.11100236062502711 2.7930574997908808e-09 8.553920123523898 -1.2442467537299442 down SYSCQVTHEGSTVEK(ub)TVAPTECS ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYSCQVTHEGSTVEKTVAPTECS 23 1 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-1 chain C regions 1 17879000.0 3697200.0 7518600.0 6663200.0 True False 4847065.003735725 6396854.187273253 5973755.981927653 1.0 1.3197376520312964 1.2324480850418895 22.208679999866103 -10.071190098641603 4.31853161014946 0.9999755284760246 1.276092868472916 0.9302603012494615 0.03563581665471739 12367425.430503992 0.0037896905070310496 3309.6850491271566 0.012199087874696134 8.488088545422645e-11 10.071190098641603 0.2761173399968915 SYSCQVTHEGSTVEK(ub)TVAPTECS ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYSCQVTHEGSTVEKTVAPTECS 23 1 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-1 chain C regions 1 80596600.0 6686700.0 10574000.0 63335900.0 True False 10144212.763250623 8686987.084960917 50817531.60388884 1.0 0.8563490620416807 5.009509637651252 23.27415357399585 -6.898889791413383 0.9682859925772787 0.8220273195325835 5.435717077681871 0.9860050517819717 0.22771063210948406 0.11222621408463758 0.1820761281175997 0.17674435186728085 0.45733704567135186 1.2621477824437333e-07 6.898889791413383 4.613689758149287 up SYSCQVTHEGSTVEK(ub)TVAPTECS ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYSCQVTHEGSTVEKTVAPTECS 23 1 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-1 chain C regions 1 19233900.0 3697200.0 6327200.0 9209500.0 True False 5064154.753073183 6047643.382747589 7034405.77560623 1.0 1.1942058798810553 1.3890582177287139 22.271890061388994 -6.971084041604862 0.23083090950930574 0.9215735360037655 1.6672636428982563 0.9999896460363626 0.000511051624464994 0.07595248247895199 0.007759934194352395 0.00497613729980292 0.01932161845259862 1.0688480232782566e-07 6.971084041604862 0.7456901068944909 SYSCQVTHEGSTVEK(ub)TVAPTECS ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYSCQVTHEGSTVEKTVAPTECS 23 1 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-1 chain C regions 1 84144800.0 6686700.0 9255100.0 68203000.0 True False 8656064.964562453 8740045.549113251 55790753.82187666 1.0 1.0097019355670978 6.445279009605581 23.0452798960883 -6.907286839494128 0.9139946041473954 0.8169241693711851 7.108488798745157 0.9898572349417117 0.2582887641530794 0.1062401377536492 0.14869460386634342 0.20866772163233402 0.5657563566494904 1.2379786657827903e-07 6.907286839494128 6.291564629373972 up SYSDPPLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYSDPPLK 8 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 26469700.0 4028700.0 19777000.0 2664000.0 False True 6111832.437421722 16247639.831593733 2137459.2323273225 1.0 2.658390915973443 0.3497247763600355 22.54317356017583 -6.713886325788735 1.781154520091883 2.0154322841330763 0.35443594332316697 0.4836970304485626 0.6984231374316098 0.3672790376526227 2.273618811746763 0.31175609469029814 0.788355417948258 1.932474065369244e-07 6.713886325788735 -1.6609963408099093 SYSDPPLK(ub)FMSVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYSDPPLKFMSVQR 14 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 11072500.0 1901200.0 4643800.0 4527500.0 True False 2492491.6112469914 3950963.1413906277 4059037.730846658 1.0 1.585146013556276 1.628506075017811 21.249157218407934 -11.464702141681549 0.4325860404254603 2.5549988046098574e-08 1.6296464598380727 0.9997329332552187 0.004683790405738456 3.9259148679790723 0.21474083574608285 3.6969994601921887 0.010185356389207721 3.430029524530712e-12 11.464702141681549 1.6296464342880845 SYSDPPLK(ub)FMSVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYSDPPLKFMSVQR 14 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 12727000.0 3579000.0 4372700.0 4775300.0 True False 3465386.6040455555 6118741.913329262 3524505.6740707587 1.0 1.7656736787134029 1.0170598772316446 21.724584880020377 -10.392410918088968 4.4793460001822085 0.9992570112775261 1.3913667779734287 0.26708279290700887 0.3056203046756569 0.0022718443848304456 0.00030815792397205917 0.2964596957965723 0.09863852918887314 4.051250353271688e-11 10.392410918088968 0.3921097666959026 SYSDPPLK(ub)FMSVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYSDPPLKFMSVQR 14 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 7084600.0 1901200.0 2927000.0 2256400.0 True False 2604125.0179981478 2797675.4617053694 1723484.7920167123 1.0 1.0743245590628396 0.6618287448202451 21.312367279930825 -6.860287704286597 1.1843712213471635 1.0403523261438923 0.641752030231575 0.9539845720471148 0.03850853322755948 0.14649975691038855 0.3903400462130461 0.02535754657707124 0.0592077962870646 1.3794701131009712e-07 6.860287704286597 -0.39860029591231727 SYSDPPLK(ub)FMSVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYSDPPLKFMSVQR 14 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 11323600.0 3579000.0 5420800.0 2323800.0 True False 2976097.076583332 5391597.07445544 2809695.8359627714 1.0 1.8116334701841077 0.9440874284881879 21.504990155454653 -6.6611079677623435 1.968457783428632 1.5219363468083116 0.9476561149622486 0.24058593996108435 0.34547868943701887 0.4817866118330739 3.5897256581859747 0.14172161017290932 0.3831506918459415 2.182187341805963e-07 6.6611079677623435 -0.574280231846063 SYSDPPLK(ub)FMSVQRPGPYDRPGTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYSDPPLKFMSVQRPGPYDRPGTAR 25 3 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 45702000.0 13940000.0 16521000.0 15241000.0 True False 13497482.330370208 23117921.455876824 11248924.87980072 1.0 1.7127580455400935 0.8334091206394775 23.686186992359776 -6.691067853045471 1.8624380646194527 1.4464006850020712 0.8363930185380364 0.37551312538792614 0.30138066193344687 0.41437631262460634 2.787523128217664 0.12940897408841143 0.3365598452461221 2.036723840386302e-07 6.691067853045471 -0.6100076664640348 SYSDPPLK(ub)FMSVQRPGPYDRPGTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYSDPPLKFMSVQRPGPYDRPGTAR 25 3 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 40231000.0 13940000.0 16073000.0 10218000.0 True False 11591727.646709021 15986411.558759311 12354536.557305962 1.0 1.3791224264398563 1.0658063175607397 23.466592267794052 -10.220515540091057 5.901495621065385 0.9999944135445366 1.2224643720003001 0.40198303652249756 0.12791076582469607 9.401909576890236e-06 1.2420158363469116e-06 0.12385217547507252 0.04128302215330602 6.018447270763384e-11 10.220515540091057 0.22246995845576356 SYSDPPLK(ub)FMSVQRPGPYDRPGTAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYSDPPLKFMSVQRPGPYDRPGTAR 25 3 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 111268000.0 17117000.0 23152000.0 70999000.0 True False 22158293.92651316 21863570.847756363 58077910.51125931 1.0 0.9866991980639741 2.6210461285454425 24.401343469853522 -6.90506379144932 0.9286849842481562 0.9411640068203022 2.811398931173126 0.9889219399613817 0.08076252925843495 0.10777374432600272 0.15713863719050766 0.06454827619661667 0.1726421098658224 1.2443318243683378e-07 6.90506379144932 1.8702349243528236 up SYSEDDIHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYSEDDIHR 9 0 Q9Y5A9;Q9Y5A9-2;Q9BYJ9;A0A024R7W5;A0A087X0Q1;A0A087WY31;Q7Z739 Q9Y5A9;Q9BYJ9;A0A024R7W5 YTHDF2;YTHDF1;YTHDF3 YTH domain-containing family protein 2;YTH domain-containing family protein 1;YTH domain-containing family protein 3 0 3024270.0 310690.0 1829800.0 883780.0 False True 407317.5987262398 1556800.9725045357 792334.9234163798 1.0 3.8220812883434223 1.9452508948647518 18.63579462378076 -9.211268109991016 9.218081535227638 1.0000006073925243 2.8836660916055465 0.5732083087562787 0.7662127996336193 0.0 0.0 0.7418823531555926 0.2472941177185308 6.147972128888164e-10 9.211268109991016 1.8836654842130223 SYSEDDIHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYSEDDIHR 9 0 Q9Y5A9;Q9Y5A9-2;Q9BYJ9;A0A024R7W5;A0A087X0Q1;A0A087WY31;Q7Z739 Q9Y5A9;Q9BYJ9;A0A024R7W5 YTHDF2;YTHDF1;YTHDF3 YTH domain-containing family protein 2;YTH domain-containing family protein 1;YTH domain-containing family protein 3 0 2898290.0 310690.0 1150600.0 1437000.0 False True 425560.4890815505 1099762.6874746147 1097610.1959439875 1.0 2.5842687836178944 2.579210768163328 18.699004685303652 -10.060778647196047 4.514092658714357 0.9999090261438421 2.581739775985312 0.999992330771181 0.002064926485069594 153764.44750514012 114234.22032196444 123.0607488646897 0.0007068791988682439 8.694034371114317e-11 10.060778647196047 1.5818307498414697 SYSFHQSQHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYSFHQSQHR 10 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8;Q8NEY8-5 F8WF16 PPHLN1 Periphilin-1 0 4668970.0 981370.0 2309500.0 1378100.0 False True 1286585.5736006 1964931.602360491 1235507.4316686445 1.0 1.5272451694460494 0.9602994600747701 20.29511598636747 -6.662454576818966 1.9641517198225953 1.338682551505963 0.9626466356965367 0.24621323214278013 0.2243556434390853 0.4785781041553163 3.5517715156203926 0.09220218389075022 0.2487878380728375 2.1754315521159935e-07 6.662454576818966 -0.3760359158094263 SYSFHQSQHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYSFHQSQHR 10 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8;Q8NEY8-5 F8WF16 PPHLN1 Periphilin-1 0 3533100.0 1186800.0 1029700.0 1316600.0 False True 1149125.6836214769 1440864.5798145619 971742.9628466384 1.0 1.2538790145858267 0.8456367973468178 20.132105168196897 -6.738524074473259 1.6920597447443655 1.1513159530009311 0.8454725495281397 0.5982905930921201 0.10667370155284987 0.32050588074993347 1.8011885385668935 0.04988500941596003 0.12261413429067052 1.825895530447207e-07 6.738524074473259 -0.3058434034727915 SYSFHQSQHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYSFHQSQHR 10 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8;Q8NEY8-5 F8WF16 PPHLN1 Periphilin-1 0 2598400.0 503200.0 1040300.0 1054900.0 False True 763391.1888476708 854650.3370990022 846398.5526209059 1.0 1.1195444086656094 1.1087350299373164 19.542063009327812 -10.088948524854073 4.616008897987908 0.9999928876178946 1.114139719304569 0.9933184323496146 0.004412910397413753 3.230273915987237e-07 6.374620084781337e-08 0.004273048308840774 0.0014242607049598612 8.148008533051951e-11 10.088948524854073 0.11414683168667439 SYSFHQSQHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYSFHQSQHR 10 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8;Q8NEY8-5 F8WF16 PPHLN1 Periphilin-1 0 4432270.0 981370.0 1886400.0 1564500.0 False True 1344209.0095270583 1803052.6105093954 1194997.321888915 1.0 1.3413484046977002 0.8889966615454828 20.358326047890362 -6.704860534705036 1.8136879168192364 1.2109465561084942 0.8902185905601464 0.4406305126925961 0.14396326266017725 0.3854808702366177 2.4684767583923453 0.06324771953686573 0.16167850032241776 1.9730562433407625e-07 6.704860534705036 -0.3207279655483478 SYSFHQSQHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYSFHQSQHR 10 0 F8WF16;B7Z8L1;F8W6A0;F8W0Q9;Q8NEY8-6;Q8NEY8-9;Q8NEY8-8;Q8NEY8-2;Q8NEY8-3;Q8NEY8;Q8NEY8-5 F8WF16 PPHLN1 Periphilin-1 0 3001620.0 1186800.0 1094500.0 720320.0 False True 986876.78415454 1088603.7112587611 870935.5816166224 1.0 1.1030796637813005 0.8825170432626553 19.912510443631174 -6.7796201593716034 1.5372433534239232 1.0583965602356564 0.8807879649561067 0.7660434738000712 0.04358452494920378 0.25118524255267516 1.172394977541135 0.022330895335083215 0.05271065639512258 1.6610390425897245e-07 6.7796201593716034 -0.17760859527954975 SYSK(ub)LLCGLLAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYSKLLCGLLAER 13 1 P14174 P14174 MIF Macrophage migration inhibitory factor 1 13259500.0 4014900.0 4297900.0 4946700.0 True False 5263572.780346903 3656670.073082985 4434862.936097004 1.0 0.6947125509000727 0.8425575405085818 22.327610966321483 -10.149230620912965 4.810123562123611 1.0000168166115404 0.7686350457061363 0.765548899547562 0.06035746427551904 1.2109135897857887e-05 2.1417167402757286e-06 0.05844558637983413 0.019480287827764457 7.092010649707286e-11 10.149230620912965 -0.23138177090540413 SYSK(ub)LLCGLLAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYSKLLCGLLAER 13 1 P14174 P14174 MIF Macrophage migration inhibitory factor 1 34541800.0 9128800.0 10410000.0 15003000.0 True False 8839011.240852483 14566767.287432848 11073264.219647666 1.0 1.6480086845129918 1.2527718223129785 23.07545356363535 -10.113601450010727 4.281895427176955 0.9999307162058154 1.4503902534639415 0.633889736721458 0.161354773493646 23143513.81746484 18221245.3861365 13776.44509002133 0.055236031151000384 7.698365916154538e-11 10.113601450010727 0.45045953725812604 SYSK(ub)LLCGLLAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYSKLLCGLLAER 13 1 P14174 P14174 MIF Macrophage migration inhibitory factor 1 31754700.0 6988800.0 7654900.0 17111000.0 True False 10602520.549718995 6288823.286993316 13729003.349982265 1.0 0.5931441733597954 1.2948810884734512 23.337903943368374 -6.749504531792108 1.6515663085335497 0.7606237628385076 1.2962327462296521 0.6468816089651723 0.17095983341423154 0.3009104910998312 1.6147229122098858 0.08177495653168623 0.19863959898937855 1.7803093315192037e-07 6.749504531792108 0.5356089833911445 SYSK(ub)LLCGLLAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYSKLLCGLLAER 13 1 P14174 P14174 MIF Macrophage migration inhibitory factor 1 17814100.0 4014900.0 6700000.0 7099200.0 True False 5499317.028592862 6403971.846062844 5422515.172613467 1.0 1.1645031215269763 0.9860342919711529 22.390821027844375 -6.664421257359482 1.9570968179801778 1.105501356905294 0.9867699370279525 0.2545725879762548 0.06996849035736118 0.47407328741211946 3.495073081151668 0.028837170258375396 0.07761203610113201 2.1656024926325615e-07 6.664421257359482 -0.11873141987734159 SYSK(ub)LLCGLLAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYSKLLCGLLAER 13 1 P14174 P14174 MIF Macrophage migration inhibitory factor 1 22106100.0 9128800.0 6674900.0 6302400.0 True False 7591001.674410141 6638940.988836092 7620202.70099483 1.0 0.8745803615373291 1.003846794907598 22.855858839069626 -11.042307213943175 8.995914662342233 1.1460154014694035 0.9392135782217279 0.22770136114770112 0.05277280043777313 0.05322643384780209 0.00025032075392115625 0.017598189244431444 0.017032348102351904 9.07178577502394e-12 11.042307213943175 -0.2068018232476756 SYSK(ub)LLCGLLAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYSKLLCGLLAER 13 1 P14174 P14174 MIF Macrophage migration inhibitory factor 1 24909900.0 6988800.0 7929600.0 9991500.0 True False 9047139.369843738 7488310.789321387 8173149.52144745 1.0 0.8276992851775561 0.9033960003634405 23.109030265460824 -10.13507278210554 4.783563403310354 1.0000093642813894 0.865547642820196 0.807932607143405 0.030903054572740698 3.2293783125148373e-06 5.838966682932479e-07 0.029923934011113967 0.00997391797496709 7.327017315705382e-11 10.13507278210554 -0.1344617214611934 SYSLLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYSLLFR 7 0 J3QQW9;Q15022 J3QQW9 SUZ12 Polycomb protein SUZ12 0 9153200.0 2656000.0 2475300.0 4021900.0 False True 3482041.720740589 2105994.8886438315 3605752.3687889944 1.0 0.6048160985836526 1.0355281923566653 21.731502058339885 -6.6654671936171885 1.9542325863261956 0.7467752304314591 1.0337302183086117 0.25892853441252706 0.16804334973851162 0.4715220248533636 3.467406396780354 0.06934853589486324 0.18633041755218846 2.160393223609091e-07 6.6654671936171885 0.28695498787715257 SYSLLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYSLLFR 7 0 J3QQW9;Q15022 J3QQW9 SUZ12 Polycomb protein SUZ12 0 3913300.0 1072500.0 638200.0 2202600.0 False True 1038454.0745568195 893036.5881690338 1625672.9834163797 1.0 0.8599673399617161 1.5654741247080832 19.9860059839909 -6.855121296953917 1.2100312367205401 0.9248007669451733 1.5966053643105156 0.9474402576799899 0.06991922580903369 0.15191499513562384 0.42545231765614555 0.045146741445594246 0.1048798974639903 1.3959784146369946e-07 6.855121296953917 0.6718045973653423 SYSLLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYSLLFR 7 0 J3QQW9;Q15022 J3QQW9 SUZ12 Polycomb protein SUZ12 0 4912800.0 2656000.0 0.0 2256800.0 False True 3637994.975701178 0.0 1723790.32025497 1.0 0.0 0.47382976935605337 21.794712119862776 -10.450067761735353 7.062236753465132 1.0000997289662479 0.236914884678029 0.7756901835503308 0.19344019331049528 0.0003037862206680996 2.3655311292260265e-05 0.18732164652784533 0.06243255393155764 3.547580330261689e-11 10.450067761735353 -0.7631848442882189 SYSLLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYSLLFR 7 0 J3QQW9;Q15022 J3QQW9 SUZ12 Polycomb protein SUZ12 0 3226530.0 1072500.0 1303100.0 850930.0 False True 891831.2698059855 1296079.9416549003 1028855.528744214 1.0 1.4532793203549115 1.1536437032175801 19.766411259425176 -10.388254341293118 5.3554750831849525 0.9998393373283326 1.3034615117862516 0.5776313599453264 0.12232572845842021 0.0002347797492900801 2.681830885663732e-05 0.11850361495559836 0.0394804590943431 4.090210494761644e-11 10.388254341293118 0.30362217445791895 SYSMIVNNLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYSMIVNNLLK 11 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 10446300.0 2485600.0 2746000.0 5214700.0 False True 3258645.670584641 2336307.503824166 4675132.866934525 1.0 0.7169565948558635 1.4346858601830583 21.635841058227438 -6.799721988090849 1.4569348008665777 0.8437693506440619 1.4445353323228796 0.8313399645876789 0.12122674420882928 0.2211801303459053 0.9269004602986509 0.06545681093994585 0.15226191696222907 1.585908080425436e-07 6.799721988090849 0.6007659816788177 SYSMIVNNLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYSMIVNNLLK 11 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 12984600.0 4535200.0 2816500.0 5632900.0 False True 4391232.558442965 3941143.137853467 4157474.50662224 1.0 0.8975027137371449 0.9467670981416637 22.066194510536054 -10.157704111738514 4.546825238734654 1.0000115231292535 0.9221349059379617 0.7690997246342357 0.0201121007188156 2.3496473038703057e-06 4.352835908518838e-07 0.019476339365890962 0.006491152594409792 6.954980044921157e-11 10.157704111738514 -0.0778766171912918 SYSMIVNNLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYSMIVNNLLK 11 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 10007000.0 2485600.0 3094100.0 4427300.0 False True 3404593.4908143245 2957392.4311795644 3381662.9231056473 1.0 0.8686477369937646 0.9932648147949104 21.69905111975033 -10.535406684907027 6.973275697712073 1.0000397545585251 0.930956275895142 0.29042325837183036 0.050874708974919955 3.146136147096585e-05 2.096068381537536e-06 0.04928756891974202 0.016419741716917832 2.9146963364677555e-11 10.535406684907027 -0.06908347866338316 SYSMIVNNLLKPISVEGSSK ddPTM_RPMI8226_Bortezomib_1h_R1 2 SYSMIVNNLLKPISVEGSSK 20 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 430522700.0 80841500.0 141257100.0 208424100.0 False True 105983989.3701995 120182091.29586306 186858373.47714114 1.0 1.1339645922939354 1.7630811463838125 26.659271097464465 -6.941213687057533 0.6481807693990889 0.9930597141708729 1.9389638902348387 0.9983185111615184 0.013641472555219632 0.08721739708305748 0.05212209967722958 0.013404346920057882 0.05386387828470505 1.14494945033592e-07 6.941213687057533 0.9459041760639658 SYSMIVNNLLKPISVEGSSK ddPTM_RPMI8226_Bortezomib_2h_R1 2 SYSMIVNNLLKPISVEGSSK 20 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 1189992200.0 636878700.0 258394500.0 294719000.0 False True 616661334.2782749 361572771.35951644 217523252.5195188 1.0 0.5863392939703156 0.35274345970483556 29.199903148800935 -9.352355157036973 0.15619168104025813 1.5523748992580328 1.1655182771463651e-13 0.9997775716491084 0.003991409948371074 0.7875448410164101 0.05834911823417647 0.3745376056064885 0.17671880937118506 4.44267805858828e-10 9.352355157036973 -1.5523748992579163 SYSMIVNNLLKPISVEGSSK ddPTM_RPMI8226_Bortezomib_8h_R1 2 SYSMIVNNLLKPISVEGSSK 20 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 511622000.0 182434000.0 267753000.0 61435000.0 False True 276765715.71191525 219970385.18626258 49292345.322083004 1.0 0.7947891400509636 0.17810134176225528 28.04408999963204 -7.054220810117054 0.5878784576580782 1.004685798684926 9.644853110028575e-12 0.9990644954148675 0.010682908543817758 0.07481642264612168 0.03930213617169936 0.011277745483898309 0.04521990967548509 8.82631026619412e-08 7.054220810117054 -1.004685798675281 down SYSMIVNNLLKPISVEGSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 SYSMIVNNLLKPISVEGSSK 20 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 817692100.0 80841500.0 173128000.0 563722600.0 False True 110730787.20939244 165478632.50226396 430582932.1113813 1.0 1.494422975512159 3.888556588125278 26.722481158987357 -6.940522695962365 0.654681912693604 0.9733495624146637 4.544230020297584 0.9982315751590414 0.053045055070388945 0.08752896627507319 0.053529633403691455 0.05184222735865331 0.20558831419725818 1.1467725902266525e-07 6.940522695962365 3.57088045788292 up SYSMIVNNLLKPISVEGSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 SYSMIVNNLLKPISVEGSSK 20 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 1017889400.0 636878700.0 186791600.0 194219100.0 False True 529592857.5602656 185785316.5755703 234829415.84234348 1.0 0.35080782137328703 0.4434149979366382 28.98030842423521 -10.759502399282592 7.060066940454591 1.0120867045108806 0.3971114096549626 0.9826116513264982 0.03780672151667323 0.007063949095846232 0.00024062953170596844 0.03595130063476336 0.012202066900731412 1.7397930864337873e-11 10.759502399282592 -0.614975294855918 SYSMIVNNLLKPISVEGSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 SYSMIVNNLLKPISVEGSSK 20 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 439959800.0 182434000.0 215183800.0 42342000.0 False True 236164409.31176615 203208632.3682377 34636190.46560855 1.0 0.8604540919625923 0.1466613473492719 27.81521632172449 -6.997138335177439 0.7028543761268911 1.0051874534948235 1.2970435957316186e-26 0.9979444524015423 0.01694485145362568 0.07891449007002185 0.05973186191062055 0.01640799453202434 0.054258527307843515 1.0066109834766233e-07 6.997138335177439 -1.0051874534948235 down SYSMIVNNLLKPISVEGSSKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 2 SYSMIVNNLLKPISVEGSSKK 21 2 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 271506000.0 66731000.0 85846000.0 118929000.0 True False 101235805.68957438 70526110.58214054 95422631.02156764 1.0 0.6966518427126378 0.9425778791563922 26.59314440046099 -9.950241769625748 6.186976395010247 1.0000000577259955 0.8196148617283718 0.4177075833075684 0.10039888395877965 7.999613098213778e-08 1.3579521191919861e-08 0.09721083325563872 0.032403600462504435 1.1213940059155588e-10 9.950241769625748 -0.1803851959976237 SYSMIVNNLLKPISVEGSSKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYSMIVNNLLKPISVEGSSKK 21 2 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 21691500.0 8320800.0 7869100.0 5501600.0 True False 6919113.873940925 7826707.59640595 6651959.123475684 1.0 1.1311719591555278 0.9613888779209991 22.722155854074895 -6.700423112790468 1.8296297829991226 1.0814195406401428 0.9618942251732956 0.4194917495402477 0.05536505858485707 0.39462767825272893 2.5686381632799065 0.0241398282758712 0.06204267605399587 1.99331937087916e-07 6.700423112790468 -0.11952531546684719 SYSPYDMLESIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYSPYDMLESIR 12 0 P07355;P07355-2;H0YN42;A6NMY6;H0YM50;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 19940000.0 3668600.0 9676100.0 6595300.0 False True 4809570.1267729355 8232463.597142379 5912881.622584858 1.0 1.7116838678192001 1.2293991909318949 22.197476522843953 -10.21832488521756 4.097926139307657 0.9997284626705796 1.4705415293267852 0.5593147304068211 0.19689189546500938 27140855.673277047 33838575.41650644 57516.31889265852 0.06740132936259266 6.048882031965537e-11 10.21832488521756 0.4708130666562056 SYSPYDMLESIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYSPYDMLESIR 12 0 P07355;P07355-2;H0YN42;A6NMY6;H0YM50;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 24090800.0 9004200.0 5821500.0 9265100.0 False True 8718366.599649888 8146055.308721452 6838292.362957926 1.0 0.934355674955052 0.7843547624198939 23.055626438349535 -6.957357983743117 0.4711939353718224 1.0039163165409342 0.7086324301695415 0.9996593111643288 0.0016658794450359392 0.08065875139787529 0.02472341595504342 0.0020786879826362823 0.012379376298494078 1.1031689160915171e-07 6.957357983743117 -0.2952838863713927 SYSPYDMLESIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYSPYDMLESIR 12 0 P07355;P07355-2;H0YN42;A6NMY6;H0YM50;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 40782400.0 7503900.0 28719000.0 4559500.0 False True 11383964.908573192 23593870.06742883 3658312.826500155 1.0 2.072552951183154 0.32135664997922675 23.440499784042974 -6.74099627509035 1.6834353327349545 1.637428757372725 0.3201793613415232 0.6092897196646285 0.45062824203646684 0.315992879339374 1.7587869151172624 0.21174990191797644 0.5189703984640683 1.815531234375115e-07 6.74099627509035 -1.317249396031202 SYSPYDMLESIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYSPYDMLESIR 12 0 P07355;P07355-2;H0YN42;A6NMY6;H0YM50;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 17725000.0 3668600.0 7667500.0 6388900.0 False True 5024980.5601872485 7328724.496968192 4879973.403525775 1.0 1.458458278432643 0.97114274275798 22.260686584366844 -6.659956501063789 1.973296530718806 1.2951173341539928 0.9731846130104018 0.23535043417621226 0.19520362711025877 0.48452332347394456 3.626917544093398 0.07992758557345989 0.21635766044435495 2.1879807611325668e-07 6.659956501063789 -0.32193272114359095 SYSPYDMLESIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYSPYDMLESIR 12 0 P07355;P07355-2;H0YN42;A6NMY6;H0YM50;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 16993300.0 9004200.0 5654200.0 2334900.0 False True 7487391.253694217 5623739.702329174 2823116.794642174 1.0 0.751094675272174 0.37704945540935525 22.83603171378381 -6.965226631297227 0.3541410674783763 1.0344674914749494 0.08097430830186875 0.9999177409837698 0.0023220405139841873 0.0778841332542202 0.014589231880213459 0.005082821816371868 0.032063863431215 1.0833614274934858e-07 6.965226631297227 -0.9534931831730806 down SYSPYDMLESIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYSPYDMLESIR 12 0 P07355;P07355-2;H0YN42;A6NMY6;H0YM50;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 15128500.0 7503900.0 7624600.0 0.0 False True 9713946.473982714 7200284.307437938 0.0 1.0 0.7412316226698152 0.0 23.211626106135423 -7.350002469721246 0.7881671160833175 0.9894517744070938 8.83431248731487e-23 0.9878221806869605 0.046766617892832735 0.1088851069644134 0.13790651028852174 0.04016350822168129 0.07150638350446074 4.466810519832499e-08 7.350002469721246 -0.9894517744070938 down SYSQSILLDLTDNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYSQSILLDLTDNR 14 0 Q6YHK3;Q6YHK3-2;Q6YHK3-4 Q6YHK3 CD109 CD109 antigen 0 8519200.0 2383800.0 2688300.0 3447100.0 False True 2308127.573826149 3761752.209299302 2544201.099216655 1.0 1.6297852215609994 1.1022792362378697 21.138291535525884 -10.384046909674845 6.072520309057166 0.9999334623489553 1.3660322288993023 0.3909797907824799 0.21535341671762384 0.00019405840744146616 1.9684367746957726e-05 0.20855277768135733 0.06950501637468522 4.13002889685773e-11 10.384046909674845 0.366098766550347 SYSSGGEDGYVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYSSGGEDGYVR 12 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 8853020.0 991720.0 4201700.0 3659600.0 False True 1300154.5238301419 3574822.7380983178 3280939.697361995 1.0 2.7495368224133863 2.523499812696596 20.31025166758961 -10.192395047387345 6.726247762107405 0.9999939498077404 2.6365183175549913 0.9858938407113982 0.0922792227984445 8.372477923383852e-06 1.0051542641240438e-06 0.08934930266832779 0.02978299109161141 6.421033749520604e-11 10.192395047387345 1.636524367747251 SYSSGGEDGYVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYSSGGEDGYVR 12 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 11084500.0 2931500.0 2132400.0 6020600.0 False True 2838441.137121975 2983878.440319093 4443624.245871546 1.0 1.0512384425715389 1.5655157289529489 21.436667393000466 -6.926133865056982 0.7778566937753841 0.9909584973496057 1.6614055153247311 0.9957227638195145 0.016701203642309294 0.09469477899700302 0.08787804926856732 0.014879386825389819 0.04756036523037971 1.1854033082489031e-07 6.926133865056982 0.6704470179751254 SYSSGGEDGYVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYSSGGEDGYVR 12 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 47131500.0 5011400.0 37395000.0 4725100.0 False True 7602660.182414976 30721570.081531428 3791181.913915102 1.0 4.040897441738973 0.49866518073294147 22.85807287741566 -6.679488642753781 1.9036658063906902 2.9249199891168183 0.5121999721086781 0.3217471878269732 1.288954272361325 0.4396926969978562 3.0802710993018234 0.5433866518166971 1.4341055794386888 2.0917576079948668e-07 6.679488642753781 -2.41272001700814 SYSSGGEDGYVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYSSGGEDGYVR 12 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 8706920.0 991720.0 3955400.0 3759800.0 False True 1358385.6842252905 3780637.3492413475 2871812.675511623 1.0 2.783184034656186 2.114136440674774 20.373461729112503 -10.313490452889956 5.551732340500739 0.9997763086012623 2.448660237665504 0.8620902575536935 0.2731375364819568 0.0007563527838365496 9.352853772637173e-05 0.2645029241649595 0.08815476083488263 4.858582114573226e-11 10.313490452889956 1.4488839290642417 SYSSGGEDGYVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYSSGGEDGYVR 12 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 5792970.0 2931500.0 1955400.0 906070.0 False True 2437672.137469695 1944865.872083488 1095525.0478056597 1.0 0.7978373474384705 0.44941443558640964 21.217072668434742 -6.962847364172896 0.39325677371258416 1.0206374942763188 0.21402963212276782 0.9998616556831785 0.002674715059479942 0.07869929447031772 0.01748497674376462 0.004491358949730051 0.029269000146313617 1.0893128726769222e-07 6.962847364172896 -0.806607862153551 down SYSSGGEDGYVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYSSGGEDGYVR 12 0 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 15088400.0 5011400.0 4717000.0 5360000.0 False True 6487356.089462414 4454494.803423749 4384534.998244336 1.0 0.6866425616221844 0.6758585374042059 22.629199199508108 SYSVGASGSSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYSVGASGSSSR 12 0 Q8N684-2;Q8N684;Q8N684-3;F5H669 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 0 15710300.0 4136400.0 5736700.0 5837200.0 False True 5422860.456954582 4880806.721481463 5233222.538376178 1.0 0.9000428390559159 0.9650299099370699 22.370622616194023 -10.00449111777776 4.484195398866982 1.0000021204661254 0.9325363744907732 0.5896412399982376 0.02653086061800874 36875492.75960106 21864844.49754599 963.1566442042478 0.009709300782644974 9.897121053258653e-11 10.00449111777776 -0.06746574597535215 SYSVGASGSSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYSVGASGSSSR 12 0 Q8N684-2;Q8N684;Q8N684-3;F5H669 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 0 9205700.0 3583500.0 1412100.0 4210100.0 False True 3469743.7540087253 1975958.894004217 3107348.509707308 1.0 0.5694826575366891 0.8955556173614467 21.72639769078148 -9.885958123051102 5.942091420891886 1.0000000642028102 0.7325191374488771 0.47291050148228053 0.13311872841562786 1.1336192901767234e-07 2.1009666549463398e-08 0.12889168720591485 0.042963884851736946 1.3002949532392162e-10 9.885958123051102 -0.2674809267539331 SYSVGASGSSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYSVGASGSSSR 12 0 Q8N684-2;Q8N684;Q8N684-3;F5H669 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 0 13415400.0 2588300.0 9260000.0 1567100.0 False True 3926640.3300763564 7607480.651289777 1257361.9981156685 1.0 1.9374019548008472 0.3202131828792219 21.904864026310115 -6.749553336470318 1.6515557947000359 1.55149483256057 0.3171183579017738 0.6470377307532286 0.3938930129882724 0.3008177444345163 1.6142493752592728 0.18841723691087267 0.45763043453754615 1.7801092770728055e-07 6.749553336470318 -1.2343764746587962 SYSVGASGSSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYSVGASGSSSR 12 0 Q8N684-2;Q8N684;Q8N684-3;F5H669 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 0 11347600.0 4136400.0 3553300.0 3657900.0 False True 5665738.862006908 3396303.456808225 2793979.3568152525 1.0 0.5994458162523205 0.4931359218743756 22.433832677716914 -13.999999999999998 0.18619575146190187 3.1197519172487267 0.41387848770462454 0.999491957577873 0.004919072389268913 12.291192967525893 0.1368290098404005 9.44131778770064 0.07538461099209806 1.0000000000000041e-14 13.999999999999998 -2.705873429544102 SYSVGASGSSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYSVGASGSSSR 12 0 Q8N684-2;Q8N684;Q8N684-3;F5H669 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 0 7455620.0 3583500.0 2916600.0 955520.0 False True 2979839.0259671286 2900887.6969002243 1155314.814174692 1.0 0.973504834194431 0.3877104783536842 21.506802966215755 -6.916361242013816 0.8512771179824922 1.0146966950173038 0.30072346527918364 0.9931089550396694 0.0234591276396876 0.10036054282645633 0.11705829627132545 0.019832178624654487 0.05748873081054678 1.212379984816091e-07 6.916361242013816 -0.71397322973812 down SYSVGASGSSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYSVGASGSSSR 12 0 Q8N684-2;Q8N684;Q8N684-3;F5H669 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 0 8073100.0 2588300.0 2499800.0 2985000.0 False True 3350605.373020621 2360683.9324991945 2441760.628686446 1.0 0.704554452012653 0.7287520781610765 21.675990348402564 -10.7524537812265 6.900004165242658 1.0055494285951179 0.7166532650868978 0.9945599676002654 0.009878639508377552 0.000853221411586189 3.061034757705805e-05 0.009677159628257463 0.003188317191594404 1.768260390693576e-11 10.7524537812265 -0.2888961635082201 SYSYVCGISSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYSYVCGISSK 11 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 42711600.0 9278600.0 13526000.0 19907000.0 False True 12164334.454090223 11507973.523935039 17847214.601427797 1.0 0.9460421831845898 1.4671755917913554 23.536154052630078 -6.881352461498844 1.0722671528254744 0.9659239623060936 1.5050734737777098 0.9747584208221021 0.03717473641717962 0.12643700173086783 0.2651253715271232 0.026673978140605965 0.06472977444177733 1.3141578647839921e-07 6.881352461498844 0.5391495114716163 SYSYVCGISSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYSYVCGISSK 11 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 8382200.0 4179000.0 1270900.0 2932300.0 False True 4046339.9324689438 1778376.9976559458 2164242.662885616 1.0 0.4395026189929719 0.5348642721584358 21.9481860949264 -10.007704800609126 5.4225709644871225 1.0000021338842797 0.4871834455751475 0.9747207063447738 0.038931231883324716 107407451.70034596 103.7730109510496 2861.734606760554 0.013327196183288953 9.824154852631427e-11 10.007704800609126 -0.5128186883091322 SYSYVCGISSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYSYVCGISSK 11 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 39365600.0 9278600.0 12409000.0 17678000.0 False True 12709149.164736805 11860729.348924452 13502820.48983841 1.0 0.9332433820065308 1.0624488165819745 23.59936411415297 -6.766285366505034 1.5887721589469688 0.9615288486763396 1.063074113449732 0.7161227451597565 0.028109355845091766 0.27247450437203363 1.3567742726043883 0.013950853418258337 0.03332193996130428 1.712831469232471e-07 6.766285366505034 0.10154526477339232 SYTIAVASLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYTIAVASLGK 11 0 A0A3B3IUC4;P06280 A0A3B3IUC4 GLA Alpha-galactosidase A 0 14774400.0 4252500.0 4636900.0 5885000.0 False True 5575068.681268581 3945092.5944946366 5276076.652906149 1.0 0.707631209593807 0.9463698035923751 22.410558147543707 -9.974742321648643 6.214971682256671 1.0000000734678607 0.827000507185949 0.4118121653743495 0.09746462286769937 9.917804373171639e-08 1.651721519717196e-08 0.09436975467675081 0.03145657176757666 1.05988239478792e-10 9.974742321648643 -0.1729995662819117 SYTIAVASLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYTIAVASLGK 11 0 A0A3B3IUC4;P06280 A0A3B3IUC4 GLA Alpha-galactosidase A 0 11475400.0 4217600.0 1721700.0 5536100.0 False True 4083714.596597515 2409183.7885468896 4086029.3305599913 1.0 0.5899491092139941 1.0005668206990774 21.96145061172468 -10.9328386000005 10.726589172713888 1.0389757299682185 0.7952579649576177 0.24896469442914526 0.16763397874796898 0.09666993774981149 0.0006052697598625303 0.10041977495236275 0.054103633995781025 1.167243327544811e-11 10.9328386000005 -0.24371776501060083 SYTIAVASLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYTIAVASLGK 11 0 A0A3B3IUC4;P06280 A0A3B3IUC4 GLA Alpha-galactosidase A 0 12594900.0 4252500.0 3759200.0 4583200.0 False True 5824764.169491436 3593106.1139879795 3500742.5539669357 1.0 0.6168672257681629 0.6010101786271268 22.4737682090666 SYTIAVASLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYTIAVASLGK 11 0 A0A3B3IUC4;P06280 A0A3B3IUC4 GLA Alpha-galactosidase A 0 8610000.0 4217600.0 2314200.0 2078200.0 False True 3507121.2713601105 2301732.9452672633 2512742.0114888735 1.0 0.6563026388804112 0.7164685270533565 21.741855887158955 -10.640537208421362 6.583887126895204 1.0013481355874683 0.6863855829668876 0.9731376388475603 0.024562620990844882 0.0004879484390804876 2.664067293635821e-05 0.023874912284539244 0.00792755183639557 2.2880356744479507e-11 10.640537208421362 -0.3149625526205807 SYTIAVASLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYTIAVASLGK 11 0 A0A3B3IUC4;P06280 A0A3B3IUC4 GLA Alpha-galactosidase A 0 12847500.0 3024400.0 6503800.0 3319300.0 False True 3915145.419836797 6141857.812700315 2715221.458894112 1.0 1.5687432148960483 0.6935173966047209 21.900634463706677 -6.731345589655546 1.7185180758812437 1.3417637869795571 0.693931119037309 0.565363669129082 0.23906243140146183 0.3337440783991131 1.9316187449633944 0.11021565839875765 0.2730567457821191 1.8563266960009063e-07 6.731345589655546 -0.6478326679422481 SYTITGLQPGTDYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYTITGLQPGTDYK 14 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 23240900.0 5710400.0 10342000.0 7188500.0 False True 7486389.69959226 8799013.912800249 6444702.976961064 1.0 1.1753347428974317 0.8608559313058562 22.83583871815462 -6.755377793358735 1.629758631738991 1.1024267510842276 0.8599578774446938 0.6718620067361232 0.07370560687369088 0.290752251188142 1.520912726270689 0.03570118799431246 0.08619548974692749 1.756395058765576e-07 6.755377793358735 -0.24246887363953384 SYTITGLQPGTDYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYTITGLQPGTDYK 14 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 19413400.0 5544000.0 5784600.0 8084800.0 False True 5368008.754632167 8094420.946290496 5967148.341198936 1.0 1.5079001015610587 1.111613004738444 22.355955593741204 -10.167306757809179 6.449685005631395 0.9999986804966648 1.3097565531497517 0.44892317506152535 0.16178352981072114 3.069740896455951e-06 3.9629571405224275e-07 0.15664689668800086 0.052215409720630976 6.802886765977094e-11 10.167306757809179 0.30975787265308685 SYTITGLQPGTDYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYTITGLQPGTDYK 14 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 23875400.0 5710400.0 8761800.0 9403200.0 False True 7821689.197757525 8374674.70460201 7182357.82498296 1.0 1.070698987502984 0.9182617262575632 22.89904877967751 -6.7805820147391 1.5334646671209382 1.0400014780484992 0.9170292596412489 0.7694781651935825 0.02990548252637276 0.24967767222460457 1.1596914174924529 0.015359055789837952 0.03622542388595071 1.6573643208111706e-07 6.7805820147391 -0.12297221840725026 SYTITGLQPGTDYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYTITGLQPGTDYK 14 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 12256400.0 5544000.0 4907200.0 1805200.0 False True 4610081.6408432415 4880763.939597066 2182658.9736982533 1.0 1.058715293966966 0.4734534317919406 22.13636086917548 -6.882207177906305 1.0674425335659488 1.0375684479054303 0.4301849515548998 0.9754214015735433 0.04125547108523005 0.1256915821043794 0.2606398680472984 0.029711165893655727 0.07226772780295235 1.31157407022111e-07 6.882207177906305 -0.6073834963505306 down SYTLNAVSFHFLGEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYTLNAVSFHFLGEQK 16 0 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 19058600.0 3621200.0 7800500.0 7636900.0 False True 5493625.145181199 6408439.829415315 6127463.367627827 1.0 1.1665229534338646 1.1153770426077592 22.389327041507443 -10.114737454790323 4.436113641375613 0.9999833298382181 1.1409499980278723 0.91012215135662 0.02088023068289826 14555653.067571053 0.0842183818886358 2478.527062014147 0.007147858340780998 7.678255247122828e-11 10.114737454790323 0.1409666681896542 SYTLNAVSFHFLGEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYTLNAVSFHFLGEQK 16 0 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 13721300.0 3621200.0 6272700.0 3827400.0 False True 4687714.784523536 5923618.73085355 3130852.472440367 1.0 1.2636474280411307 0.6678845911822235 22.160453363599892 -6.786407847068043 1.5106541772514404 1.148043637868321 0.6621604015686424 0.7894756911621829 0.11184145733756357 0.2407490157238232 1.08540279696953 0.05828703680192613 0.13682985773115616 1.6352801043505628e-07 6.786407847068043 -0.48588323629967856 SYTVGVMMMHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYTVGVMMMHR 11 0 P50454;E9PPV6;E9PR70;E9PKH2;E9PK86;E9PMI5 P50454 SERPINH1 Serpin H1 0 15226600.0 2982900.0 5090900.0 7152800.0 False True 3910610.786444692 4331357.564172776 6412696.870502488 1.0 1.10759106459444 1.6398197674723216 21.898962524620718 -6.940044777903982 0.6591518292705224 0.9940304999408234 1.7835317737077772 0.9981696999905837 0.011967177163800505 0.08774628664403103 0.05451771480061128 0.011653073860672124 0.04579884667169174 1.1480352472958675e-07 6.940044777903982 0.7895012737669538 SYTVGVMMMHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYTVGVMMMHR 11 0 P50454;E9PPV6;E9PR70;E9PKH2;E9PK86;E9PMI5 P50454 SERPINH1 Serpin H1 0 6472600.0 3502700.0 1078200.0 1891700.0 False True 3391508.7057810468 1508730.88273872 1396207.020216457 1.0 0.44485537665493535 0.4116772626402319 21.693495765443345 -13.949616576781235 0.4011533323768538 9.999999999999998 0.4097608436350051 0.9998385836506943 0.0034285336493573887 25.805918362356675 0.20869490020504308 201.93275253303108 0.008465823189882817 1.1230094820694545e-14 13.949616576781235 -9.590239156364992 SYTVGVMMMHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYTVGVMMMHR 11 0 P50454;E9PPV6;E9PR70;E9PKH2;E9PK86;E9PMI5 P50454 SERPINH1 Serpin H1 0 51991500.0 9126500.0 11734000.0 31131000.0 False True 13845567.736522788 9639976.021839557 24977944.20479797 1.0 0.6962499628246062 1.8040390022367543 23.722920876737092 -6.833609469447439 1.3115944975146434 0.8380501321981695 1.8361301611476406 0.9129144625941072 0.13792304022684776 0.1764048586977463 0.5921938882914962 0.08252914269377531 0.18994186099959962 1.4668662979989712e-07 6.833609469447439 0.9980800289494711 SYTVGVMMMHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYTVGVMMMHR 11 0 P50454;E9PPV6;E9PR70;E9PKH2;E9PK86;E9PMI5 P50454 SERPINH1 Serpin H1 0 12483800.0 2982900.0 4411100.0 5089800.0 False True 4085758.739841507 4216203.016442958 3887694.067721439 1.0 1.0319265734732324 0.9515231601443626 21.96217258614361 -6.799002728029541 1.46035707479676 1.017637731086146 0.9504451612409228 0.829118724767798 0.013664428490294908 0.222190727210001 0.9356627492754039 0.0073619848211287945 0.01712891121502509 1.5885367701407003e-07 6.799002728029541 -0.06719256984522315 SYTVGVMMMHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYTVGVMMMHR 11 0 P50454;E9PPV6;E9PR70;E9PKH2;E9PK86;E9PMI5 P50454 SERPINH1 Serpin H1 0 69208500.0 9126500.0 25955000.0 34127000.0 False True 11814434.16021047 24510581.43372133 27916236.17259038 1.0 2.074630160136648 2.3628923564201454 23.49404719882954 -10.418103427755844 0.2852425757845432 3.8783583191731575e-19 2.4707501382126513 0.9990637712571321 0.01794436698852063 1.9697481360492481 0.13740660037473848 1.554161263958488 0.11002058528085405 3.818533211805646e-11 10.418103427755844 2.4707501382126513 SYVDLLK(ub)LEDVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYVDLLKLEDVLR 13 1 Q9BXJ9;A0A0B4J1W3 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 1 2785020.0 1248000.0 712140.0 824880.0 True False 1037767.2957742361 708303.5604712781 997358.5941858047 1.0 0.6825263846292647 0.9610618856915469 19.985051545900514 -10.212039936780975 7.368482936618665 1.000000278517041 0.8217941357995555 0.3530795097770161 0.1137116421421722 5.203678831657218e-07 5.544128729055442e-08 0.11010099633554436 0.03670027469054422 6.137055675336322e-11 10.212039936780975 -0.17820614271748547 SYVISSFTELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYVISSFTELK 11 0 Q00722-3;Q00722-2;Q00722 Q00722-3 PLCB2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 0 52169500.0 9649100.0 3875400.0 38645000.0 False True 12650063.542017331 3297205.4261908797 34646386.10901579 1.0 0.26064734103818327 2.7388309943216824 23.592641295891838 -6.826746179772851 1.3423394075494912 0.6039560679710304 2.801211006065023 0.8992113712428947 0.3297837343547178 0.1848660900105218 0.6525943694870835 0.19295534399209016 0.44416037211300313 1.4902317782902559e-07 6.826746179772851 2.1972549380939927 up SYVISSFTELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYVISSFTELK 11 0 Q00722-3;Q00722-2;Q00722 Q00722-3 PLCB2 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 0 50912240.0 2997200.0 739040.0 47176000.0 False True 2902055.5265843365 1034142.5260426875 34819190.35033651 1.0 0.3563482905717705 11.99811307239804 21.468643692850637 -6.8938174224849345 0.9994948653526893 0.4305097019903991 13.077755329562843 0.9832323336228932 0.691831033259999 0.11610167847187076 0.20417750529145848 0.5245682357532265 1.3271134910090214 1.2769755368365906e-07 6.8938174224849345 12.647245627572444 up SYVSSLLAHYLFQGGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYVSSLLAHYLFQGGLR 17 0 Q8N2E6;Q5JU69-2;Q5JU69 Q8N2E6 TOR2A Prosalusin;Salusin-alpha;Salusin-beta;Torsin-2A 0 220131000.0 84750000.0 56775000.0 78606000.0 False True 128571946.05492868 46643057.664900355 63069489.645766295 1.0 0.3627778772592697 0.4905385006681136 26.938000645134316 -9.77253455107814 6.288590016985293 1.000000010949304 0.4266581889649593 0.9640955591388681 0.05215805609692746 8.008538784078096e-09 1.55566911941366e-09 0.05050182141028578 0.016833940219250453 1.6883615335069716e-10 9.77253455107814 -0.5733418219843447 SYVSSLLAHYLFQGGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYVSSLLAHYLFQGGLR 17 0 Q8N2E6;Q5JU69-2;Q5JU69 Q8N2E6 TOR2A Prosalusin;Salusin-alpha;Salusin-beta;Torsin-2A 0 173081000.0 84750000.0 45224000.0 43107000.0 False True 109710545.67225523 42707244.64490902 35261968.31517139 1.0 0.38927201011733986 0.3214091051967925 26.709126967226766 -13.999999999999998 0.3102109535044981 6.910786842046626 0.3064142679039677 0.9996724599110304 0.00552272461474781 17.28484387824433 0.17722419845346515 65.95408833541657 0.023496695371734017 1.0000000000000041e-14 13.999999999999998 -6.604372574142658 SYVTMTATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 SYVTMTATK 9 0 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 19675100.0 6683500.0 4622900.0 8368700.0 False True 8762133.22310607 3933181.339923064 7502787.202238862 1.0 0.44888399203416807 0.8562740386614683 23.0628507194853 -9.90366449743914 6.051831426296468 1.0000000805412559 0.6525790153476981 0.4923042180110172 0.16631629008801646 1.8075222670196133e-07 3.29103133322763e-08 0.1610350938218306 0.05367835180942813 1.2483475192513005e-10 9.90366449743914 -0.34742106519355775 SYVTMTATK ddPTM_RPMI8226_Bortezomib_2h_R1 1 SYVTMTATK 9 0 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 12426000.0 3558400.0 1808500.0 7059100.0 False True 3445440.5397696826 2530643.48120291 5210109.941539357 1.0 0.7344905395964477 1.5121752592739963 21.716257029440136 -6.814545580134746 1.3951774025237778 0.8560569573737016 1.527265314431293 0.8714130615692931 0.11574142345472893 0.2006587396866297 0.7688742794638497 0.06521222370843086 0.1505747743692593 1.5326903387922058e-07 6.814545580134746 0.6712083570575915 SYVTMTATK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYVTMTATK 9 0 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 19863400.0 5446500.0 9827000.0 4589900.0 False True 8262738.69248577 8073295.071298555 3682704.2531753643 1.0 0.977072538750439 0.44570019581091896 22.97818861285725 -6.9159513804323955 0.8542095696175568 1.0135206912689818 0.36751131741833937 0.9929804661369762 0.021453932010320573 0.10061310370927527 0.11838962737891369 0.01809883746954433 0.05228328827975204 1.2135246977899182e-07 6.9159513804323955 -0.6460093738506425 down SYVTMTATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 SYVTMTATK 9 0 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 15073600.0 6683500.0 3546600.0 4843500.0 False True 9154570.564796241 3389899.4849621668 3699565.055013715 1.0 0.37029584959429696 0.40412218452281473 23.126060781008192 -9.933652238212659 5.367863864499931 1.0000011569184295 0.3872090170555793 0.9977198935205459 0.013809543417664369 37817259.31447828 12.551006569226804 540.765369606279 0.004727374022587035 1.1650585779375504e-10 9.933652238212659 -0.6127921398628502 SYVTMTATK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYVTMTATK 9 0 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 10685400.0 3558400.0 5220200.0 1906800.0 False True 2958967.263848594 5192077.746471434 2305503.063952931 1.0 1.7546925273239877 0.7791580164203197 21.496662304874413 -6.700124887538794 1.8302293590753596 1.4685671696415847 0.7820330804068478 0.41827724543920264 0.3185565494882764 0.39525314156326485 2.5740791940381147 0.13884533378271102 0.3570443573832936 1.9946886314765248e-07 6.700124887538794 -0.6865340892347369 SYVTMTATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYVTMTATK 9 0 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 19962100.0 5446500.0 8891400.0 5624200.0 False True 7050601.616565642 8396585.773831246 4600653.309165263 1.0 1.190903447743121 0.6525192542939686 22.749314934949698 -6.810869751589006 1.4110006071234205 1.1039347085156728 0.6429238501635245 0.8620462373962001 0.08277914079844703 0.20562411821027246 0.8067106454659888 0.04612912452048173 0.10665839292124782 1.5457179432841967e-07 6.810869751589006 -0.4610108583521483 SYYETSKMK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 SYYETSKMK 9 1 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 2777270.0 523540.0 1399000.0 854730.0 True False 435346.7067545222 1391463.3093202426 1033450.0911749976 1.0 3.1962187556063064 2.373855309206982 18.731805284335945 -10.324961565530295 5.841927778138571 0.9997967074595823 2.78503703240665 0.8626771813055193 0.33572847113251386 0.0008890246960322447 0.00010272720671868246 0.3251022522262946 0.1083558981286559 4.731931340559108e-11 10.324961565530295 1.7852403249470674 SYYFPVK(ub)NVIDGDLCEQFNSMEPNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 SYYFPVKNVIDGDLCEQFNSMEPNK 25 1 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 1 60039000.0 5919000.0 14273000.0 39847000.0 True False 8979555.736862794 11725871.63454201 31971222.984439462 1.0 1.3058409545146052 3.5604459642910258 23.0982126387806 -6.931651152463547 0.7331162766085355 0.9677269600029207 4.043380578871092 0.9968528139652314 0.06405282733808727 0.09178976482393018 0.07354745366052316 0.05893881469266861 0.2021829478542084 1.1704391701244079e-07 6.931651152463547 3.075653618868172 up SYYFPVK(ub)NVIDGDLCEQFNSMEPNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 SYYFPVKNVIDGDLCEQFNSMEPNK 25 1 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 1 46148800.0 5919000.0 8508800.0 31721000.0 True False 7662262.180933072 8035277.800163665 25948103.484945633 1.0 1.0486821790252507 3.3864807640640926 22.869338960873048 -6.911398327653156 0.8861491292508245 0.9307786265905705 3.6978255254875543 0.9914388373682552 0.10304688151534394 0.10350087442031407 0.1338019422578238 0.08495346492201014 0.23684833997477112 1.2263139604924595e-07 6.911398327653156 2.7670468988969836 up TAADK(ub)DRGEEDADGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAADKDRGEEDADGSK 16 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 8567000.0 3086600.0 3549100.0 1931300.0 True False 4227799.432228632 3392289.026695774 1475166.7163720422 1.0 0.8023770003932212 0.3489206950374243 22.011475505885684 -6.957272184822134 0.4723136896501334 1.0117116647612499 0.1209240433876813 0.9996552554435133 0.005060628121343048 0.0806903843818916 0.02484413059592009 0.006297352504456975 0.037420394495796955 1.1033868789180942e-07 6.957272184822134 -0.8907876213735686 down TAADK(ub)DRGEEDADGSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAADKDRGEEDADGSK 16 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 2524910.0 1889900.0 0.0 635010.0 True False 1571535.5867658092 0.0 767787.6550454955 1.0 0.0 0.48855887293369415 20.58374351105629 -10.210581648007153 5.686980367438697 1.00002448807069 0.24427943646682546 0.7613518793827124 0.19945332466621507 6.192874142380504e-05 8.596776708128934e-06 0.1931260871557907 0.06437328373148395 6.157697526052223e-11 10.210581648007153 -0.7557450516038646 TAADKDRGEEDADGSK(ub)TQDLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAADKDRGEEDADGSKTQDLFR 22 3 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 104513700.0 2203700.0 31628000.0 70682000.0 True False 3343174.0120501015 25983736.289308067 56711671.71897884 1.0 7.772175841177444 16.963422039824394 21.67278701844286 -7.045620623586889 0.34095902082487756 1.1001278808189879e-18 24.32324439031226 0.9999342023290262 0.05306540451354101 0.07669842591479403 0.014524340631765987 0.14303445565814787 0.798304258307862 9.002836777660781e-08 7.045620623586889 24.32324439031226 TAADKDRGEEDADGSK(ub)TQDLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAADKDRGEEDADGSKTQDLFR 22 3 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 64847700.0 2203700.0 23651000.0 38993000.0 True False 2852733.0914212232 22334801.059100106 31896674.10196672 1.0 7.829264197995114 11.181093035968496 21.44391334053531 -8.588244566799958 0.4031044381235635 3.9038875349950673e-19 11.913594608058508 0.9968611269723626 0.2373503511628607 0.23187206335957505 0.1299095734787402 1.1764847559089469 0.8276089333042316 2.580806436670115e-09 8.588244566799958 11.913594608058508 TAAELLQSQGSQAGGSQTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAAELLQSQGSQAGGSQTLK 20 0 Q14141;B1AMS2;Q14141-2;Q14141-4 Q14141 SEPT6 Septin-6 0 4268400.0 0.0 2233200.0 2035200.0 False True 0.0 1900015.2649454202 1824617.0270169212 0.0 TAAELLQSQGSQAGGSQTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAAELLQSQGSQAGGSQTLK 20 0 Q14141;B1AMS2;Q14141-2;Q14141-4 Q14141 SEPT6 Septin-6 0 5386130.0 1460500.0 868330.0 3057300.0 False True 1414137.22693728 1215058.6972811287 2256501.4129659985 1.0 0.859222622908165 1.5956735810237455 20.43149069443317 -6.857202891875565 1.1998376881477315 0.9241194511337075 1.629468015146184 0.9501407373385872 0.07127506012837877 0.1497142391168575 0.4111587391564845 0.04638247823045402 0.10794867001660755 1.3893034306267648e-07 6.857202891875565 0.7053485640124765 TAAELLQSQGSQAGGSQTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAAELLQSQGSQAGGSQTLK 20 0 Q14141;B1AMS2;Q14141-2;Q14141-4 Q14141 SEPT6 Septin-6 0 5055900.0 0.0 1759600.0 3296300.0 False True 0.0 1681855.0537809231 2517781.8294294835 0.0 TAAELLQSQGSQAGGSQTLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAAELLQSQGSQAGGSQTLKR 21 1 Q14141;B1AMS2;Q14141-2;Q14141-4 Q14141 SEPT6 Septin-6 1 9338800.0 2728800.0 3031200.0 3578800.0 True False 2642175.7376696 4241573.967499175 2641404.918301345 1.0 1.6053337811815063 0.9997082633992638 21.333294996330032 -10.468959927571731 5.483699577080587 0.9996295826350117 1.302521022290386 0.24963871657451053 0.2472455822958959 0.001121029994096601 0.00010855991922170044 0.23968235636595314 0.07979816855461283 3.396566113198675e-11 10.468959927571731 0.30289143965537435 TAAELLQSQGSQAGGSQTLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAAELLQSQGSQAGGSQTLKR 21 1 Q14141;B1AMS2;Q14141-2;Q14141-4 Q14141 SEPT6 Septin-6 1 7927600.0 2728800.0 3522300.0 1676500.0 True False 2269118.106337129 3503324.670778188 2027048.3987398176 1.0 1.5439146428712553 0.8933199171425823 21.11370027176431 -6.684949402327269 1.8850026297607025 1.342610926255435 0.8957329440274653 0.34666435858400113 0.2302800001529965 0.4275849515590874 2.9417098439087077 0.09789134116161549 0.25649030765544584 2.06562079786653e-07 6.684949402327269 -0.4468779822279698 TAAFLIPLLVWITTLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAAFLIPLLVWITTLPK 17 0 Q9BUQ8;H0YI52 Q9BUQ8 DDX23 Probable ATP-dependent RNA helicase DDX23 0 21533300.0 4245600.0 8896100.0 8391600.0 False True 6440885.594935745 7308521.449453449 6732996.581831057 1.0 1.134707540093539 1.045352612244035 22.618827635860136 -10.225833784863811 4.126379799104773 0.9999424714384888 1.090030076176 0.5751114255606855 0.03647899656312287 25708894.311313715 1.4396623209503123 14052.463373355662 0.012487730804468843 5.945196523126817e-11 10.225833784863811 0.0900876047375112 TAAFLLPVIMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAAFLLPVIMR 11 0 Q5T1V6-2;Q5T1V6 Q5T1V6-2 DDX59 Probable ATP-dependent RNA helicase DDX59 0 1251100.0 285200.0 528540.0 437360.0 False True 373899.96188072866 449683.8922327837 392106.18265336147 1.0 1.2026850443387571 1.0486927591034108 18.512292798549485 -10.296320487680928 3.401085478675557 0.9994935945204008 1.1256889016710119 0.47040878081734194 0.06286708799825907 11412177.043863744 17386800.414974414 58821.84746866622 0.02272476925113425 5.0545152630928505e-11 10.296320487680928 0.1261953071506111 TAAFLLPVIMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAAFLLPVIMR 11 0 Q5T1V6-2;Q5T1V6 Q5T1V6-2 DDX59 Probable ATP-dependent RNA helicase DDX59 0 820870.0 285200.0 535670.0 0.0 False True 390646.1472402015 512002.3281761924 0.0 1.0 1.3106550052863344 0.0 18.575502860072376 -6.880011673888804 1.3399608537240248 1.1622354225455152 2.6000324830076175e-18 0.9303096088735509 0.14762236942324572 0.14885286558166572 0.5372494082670521 0.0893791083768621 0.18213558820672102 1.3182213041302456e-07 6.880011673888804 -1.1622354225455152 down TAAFVLAMLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAAFVLAMLSR 11 0 Q9NUU7;I3L0H8;F6QDS0;Q9NUU7-2;I3L352;E9PR46;J3QL17;H0YD26;A0A1B0GV69;Q9UHL0-2;Q9UHL0 Q9NUU7 DDX19A;DDX25 ATP-dependent RNA helicase DDX19A;ATP-dependent RNA helicase DDX25 0 7757500.0 2405000.0 5352500.0 0.0 False True 3294193.4926812216 5116008.851649463 0.0 1.0 1.5530383576483309 0.0 21.651493867173254 -6.82854107739679 1.456507668920868 1.300017366452621 1.631773528315334e-20 0.8602969090266239 0.2402279696408746 0.19630258879637316 0.8350079469341644 0.13191542417314733 0.28641029991104533 1.4840855023837108e-07 6.82854107739679 -1.300017366452621 down TAAFVLAMLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAAFVLAMLSR 11 0 Q9NUU7;I3L0H8;F6QDS0;Q9NUU7-2;I3L352;E9PR46;J3QL17;H0YD26;A0A1B0GV69;Q9UHL0-2;Q9UHL0 Q9NUU7 DDX19A;DDX25 ATP-dependent RNA helicase DDX19A;ATP-dependent RNA helicase DDX25 0 17108400.0 4605100.0 6074300.0 6429000.0 False True 5961392.730092064 5736259.865261159 5258987.967110602 1.0 0.9622348543328686 0.8821743852848605 22.507217988949414 -6.958890572889901 0.45080896300620926 1.0025605450825792 0.8386706292808603 0.999726764334627 0.0008119961709603014 0.0801000325123729 0.02261495109491573 0.0010713857939608257 0.006621524697557443 1.0992827855832895e-07 6.958890572889901 -0.16388991580171886 TAATLATHELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAATLATHELR 11 0 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 0 3413440.0 633540.0 1625400.0 1154500.0 False True 830577.0752100882 1382896.6557595762 1035043.4147459887 1.0 1.6649829341964237 1.2461738297847702 19.663754526867535 -10.221173569820348 4.4654060299470855 0.9998483697493801 1.4555783819972083 0.6120617970072718 0.17097810092920773 120443408.41011217 51.10666768404771 187778.95802145227 0.05853035169561335 6.009335208252496e-11 10.221173569820348 0.4557300122478283 TAATLATHELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAATLATHELR 11 0 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 0 3076390.0 652340.0 716450.0 1707600.0 False True 631631.8237728626 1002532.2212373917 1260328.3330980707 1.0 1.5872098008758762 1.9953528078586649 19.26872433537953 -7.751370366888196 0.10979763688240568 9.120833250044103e-20 3.2744547674710986 0.9999914770522945 0.0011926729148086946 0.13662624944404797 0.014033163027857414 0.17246463537979242 0.22500300409702884 1.7726770948115798e-08 7.751370366888196 3.2744547674710986 TAATLATHELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAATLATHELR 11 0 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 0 6346600.0 1262500.0 5084100.0 0.0 False True 1915304.8011132437 4176802.632745396 0.0 1.0 2.1807508811744682 0.0 20.869142569862404 -6.763438505815138 1.6241382097552222 1.6859770813427077 3.895664952060992e-10 0.689395097855223 0.49674244867499356 0.2806716656494334 1.4640112714731128 0.24224038533586337 0.574526343661959 1.7240961981685103e-07 6.763438505815138 -1.6859770809531411 TAATLATHELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAATLATHELR 11 0 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 0 2916740.0 633540.0 1064000.0 1219200.0 False True 867776.8587747461 1016988.9618225179 931250.0702121839 1.0 1.1719475479657884 1.0731446232929724 19.726964588390427 -10.712354600369709 6.337815445025577 0.9981581426686591 1.1225460856293803 0.6722550243478145 0.040336125090506936 0.001064783698876875 4.8325751150876805e-05 0.03961408636303915 0.01301842839383939 1.9393017958643177e-11 10.712354600369709 0.1243879429607212 TAATLATHELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAATLATHELR 11 0 Q8N1G4 Q8N1G4 LRRC47 Leucine-rich repeat-containing protein 47 0 2243510.0 652340.0 938620.0 652550.0 False True 542449.6135619917 933563.4677585169 788995.1879496987 1.0 1.7210141631925566 1.4545041018072944 19.049129610813807 -10.446799459199347 5.652669959891561 0.9995613286159925 1.5877591324999265 0.8663995476928992 0.10880227695195605 0.0006019251436980165 5.89076009110452e-05 0.10542251067998608 0.03511578388869722 3.574378513599425e-11 10.446799459199347 0.5881978038839341 TAAYGHFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAAYGHFGR 9 0 P31153 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 6299400.0 1990700.0 1840600.0 2468100.0 False True 2609826.977966221 1565989.6546026058 2212724.6876869467 1.0 0.6000358138005555 0.8478434418711055 21.31552273385715 -10.303830635526818 6.137849140811773 1.0000147238550563 0.7239396278358303 0.623308663817101 0.10116704052370765 2.0384585612871753e-05 2.3119894415884763e-06 0.0979597872038976 0.0326515219277841 4.9678601835885115e-11 10.303830635526818 -0.276075096019226 TAAYGHFGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAAYGHFGR 9 0 P31153 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 5070200.0 1623500.0 1322800.0 2123900.0 False True 1571962.881158969 1851000.9383108697 1567586.874365774 1.0 1.1775093168524267 0.9972162149337975 20.584135720890078 -6.6497175012081335 2.0093513860908176 1.1152100883475566 0.9979709015531825 0.19299336664225752 0.07576785649372496 0.5092140956188381 3.940406599572956 0.03058316005511955 0.08393139981252443 2.2401778500409504e-07 6.6497175012081335 -0.11723918679437417 TAAYGHFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAAYGHFGR 9 0 P31153 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 4967800.0 1990700.0 1415600.0 1561500.0 False True 2726715.5866447017 1353054.1112368014 1192705.8601019736 1.0 0.4962212112858355 0.43741483928275443 21.378732795380042 -13.999999999999998 0.30309759690894095 5.678095066014879 0.42340459815908016 0.9996567303731271 0.004677983757462845 16.793055223801765 0.17493795284446972 49.35447645532337 0.020973127740354366 1.0000000000000041e-14 13.999999999999998 -5.254690467855799 TAAYGHFGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAAYGHFGR 9 0 P31153 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 4452700.0 1623500.0 1701400.0 1127800.0 False True 1350012.1832447697 1692234.220498541 1363617.765641972 1.0 1.2534955176709863 1.0100781182318674 20.364540996324354 -10.823085607166849 2.927951240090226 0.960019379083515 1.131786818007998 0.28100093078813604 0.09937473757591136 74711694.3920282 21662159.756123707 20454308.5215604 0.03636742958423865 1.5028456992739506e-11 10.823085607166849 0.17176743892448298 TAAYGHFGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAAYGHFGR 9 0 P31153 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 11448000.0 3291900.0 2788100.0 5368000.0 False True 4261429.443050102 2632939.7840631288 4391079.08033127 1.0 0.6178536613711036 1.0304239783888973 22.022906014912124 -11.901383643819276 17.605704932317487 0.8986003446042146 0.8417249380331235 0.0 0.1921602383308361 0.0 0.0 0.0 0.055888328244035224 1.2549209112417894e-12 11.901383643819276 -0.056875406571091025 TACEK(ub)LIQVLIGDEPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TACEKLIQVLIGDEPER 17 1 Q9BTY7 Q9BTY7 HGH1 Protein HGH1 homolog 1 4399300.0 1304000.0 1137100.0 1958200.0 True False 1709556.6279539627 967449.1123810842 1755584.2483807676 1.0 0.5659064441398177 1.0269237179243906 20.705190781224037 -10.108448572470285 13.36056718698116 1.0000001717030913 0.7964150810321042 0.20635757745975425 0.18820951389688867 0.0 0.0 0.18223307823009904 0.060744359410033 7.790250583283994e-11 10.108448572470285 -0.20358509067098707 TADGIVSHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TADGIVSHLK 10 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 8358300.0 2851600.0 0.0 5506700.0 False True 3738475.2149336822 0.0 4936919.507996311 1.0 0.0 1.3205703459729607 21.834018537725612 -6.704241951353043 1.8161429472183774 0.38161488729028376 1.3169126376325655 0.43751398573907985 0.4217967969613859 0.38678149191014677 2.4831625060740588 0.18509685481349492 0.4734728464038859 1.9758685502251272e-07 6.704241951353043 0.9352977503422817 TADGIVSHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TADGIVSHLK 10 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 17728500.0 4812900.0 3596300.0 9319300.0 False True 4660117.123948261 5032321.344456748 6878295.756992772 1.0 1.0798701428759667 1.4759920349738271 22.151934784292973 -6.939986832420987 0.6596892815067343 0.9955526981192464 1.5827709795618872 0.9981621368801282 0.0089225644252173 0.08777268615765359 0.054637695175944516 0.008684566697231631 0.03409540336410151 1.1481884334352193e-07 6.939986832420987 0.5872182814426408 TADGIVSHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TADGIVSHLK 10 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 13307200.0 2851600.0 4869000.0 5586600.0 False True 3905913.5815924224 4653871.480370154 4267160.139638606 1.0 1.191493714121753 1.09248708413536 21.897228599248503 -10.1600008373705 4.965142436240533 0.999990416251831 1.1419903991288707 0.7327905880710184 0.04041928743762586 4.2884200733780585e-06 7.254852642163696e-07 0.03913844765448123 0.013045268925801814 6.918296369892832e-11 10.1600008373705 0.14199998287703963 TADGIVSHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TADGIVSHLK 10 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 4812900.0 4812900.0 0.0 0.0 False True 4002139.5976216523 0.0 0.0 1.0 0.0 0.0 21.93234005972725 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 TADGIVSHLKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TADGIVSHLKK 11 1 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 17592800.0 2039200.0 13703000.0 1850600.0 False True 3093615.4854892064 11257592.587972334 1484828.0988532072 1.0 3.638976026845212 0.4799653046145795 21.560862460470723 -6.68504380869319 1.8838810168587568 2.6620852359857614 0.4914512780210357 0.3473799271293144 1.1172480289455418 0.4274220647972598 2.9369599007570253 0.47512017464433176 1.2450979209045725 2.0651718247220543e-07 6.68504380869319 -2.170633957964726 TADGIVSHLKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TADGIVSHLKK 11 1 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 6628800.0 2039200.0 1752600.0 2837000.0 False True 2639784.598641447 1655066.2693407838 2320695.1100782044 1.0 0.6269701968079351 0.8791229069495062 21.331988782563172 -10.170654839392851 7.254255741023675 1.000000237866356 0.7530465518787207 0.5611946699917576 0.1029409128511264 3.9603664642281534e-07 4.524744082722565e-08 0.0996722068173937 0.033224036759650126 6.750643298067568e-11 10.170654839392851 -0.24695368598763523 TADNATK(ub)NAEPLINLDVNNPDFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TADNATKNAEPLINLDVNNPDFK 23 1 Q9Y224;G3V4C6;H0YJB9 Q9Y224 C14orf166 UPF0568 protein C14orf166 1 24055500.0 11176000.0 7935500.0 4944000.0 True False 10821223.9974331 11104186.5330858 3649018.083179243 1.0 1.026148847461232 0.337209365968658 23.367360357013453 -6.898074468058185 0.9733319921717374 1.0301764531222997 0.26764897342662725 0.9855845968365363 0.038274609942563105 0.112837561610547 0.18550843920885263 0.029595426395171626 0.07628697585386356 1.2645195029345287e-07 6.898074468058185 -0.7625274796956725 down TADNATK(ub)NAEPLINLDVNNPDFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TADNATKNAEPLINLDVNNPDFK 23 1 Q9Y224;G3V4C6;H0YJB9 Q9Y224 C14orf166 UPF0568 protein C14orf166 1 20811300.0 11176000.0 6493000.0 3142300.0 True False 9293339.180747489 6458020.920240414 3799340.401646364 1.0 0.6949085570468739 0.4088240327564126 23.14776563244773 -7.117621285452207 0.22223927645316857 1.1370637232496943 4.4808983232129226e-14 0.9999882419958102 0.0008276985486081357 0.0785639263860497 0.008664986102437053 0.009816840108756891 0.03155643410016711 7.627438498833004e-08 7.117621285452207 -1.1370637232496494 down TADNATK(ub)NAEPLINLDVNNPDFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TADNATKNAEPLINLDVNNPDFK 23 1 Q9Y224;G3V4C6;H0YJB9 Q9Y224 C14orf166 UPF0568 protein C14orf166 1 38659000.0 10347000.0 10504000.0 17808000.0 True False 13394395.46986221 9919443.166241921 14567126.725510286 1.0 0.740566693626522 1.0875538771635314 23.67512613361034 -6.706576661761084 1.8074016095035466 0.8399508467451033 1.0866592605421825 0.44882305278607215 0.10938424972604466 0.3820036855051437 2.4303537598504246 0.048200812914918775 0.12296402523807501 1.965275039161644e-07 6.706576661761084 0.2467084137970792 TAEAGGVTGK(ub)GQDGIGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAEAGGVTGKGQDGIGSK 18 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 4293350.0 2059400.0 1236400.0 997550.0 True False 2699893.343257968 1051933.9394494528 894333.0951752813 1.0 0.3896205537438311 0.3312475648004996 21.36447098541803 -13.999999999999966 0.3319649399499084 7.723610199185122 0.3211460513911388 0.9997189060088161 0.005070572575846102 18.990467493254478 0.1843484409672124 89.23813609717777 0.018569551054184803 1.0000000000000778e-14 13.999999999999966 -7.4024641477939825 TAEAGGVTGK(ub)GQDGIGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAEAGGVTGKGQDGIGSK 18 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 6720600.0 2825100.0 2399000.0 1496500.0 True False 2735418.7468815544 3356933.2106197258 1104521.755962323 1.0 1.2272099891275197 0.40378525489799516 21.383330271741055 -6.833112404469701 1.3138550951544192 1.121170864569801 0.3801705155550894 0.9119739848592541 0.1030206033887638 0.17700055743673448 0.5964351004143662 0.06154282664235376 0.14163649522123625 1.4685461380829617e-07 6.833112404469701 -0.7410003490147117 down TAEAGGVTGK(ub)GQDGIGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAEAGGVTGKGQDGIGSK 18 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 5410900.0 0.0 2108500.0 3302400.0 True False 0.0 1732221.7012143089 2649679.1925066584 0.0 TAEAGGVTGK(ub)GQDGIGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAEAGGVTGKGQDGIGSK 18 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 4587000.0 2059400.0 1330000.0 1197600.0 True False 2820815.833192394 1271236.202278147 914751.5453462212 1.0 0.4506626016911761 0.32428616380494857 21.427681046940922 -13.999999999999956 0.20645469810092168 4.131634213334901 0.24724103137645723 0.999488329692495 0.006634943480005134 12.66602325567123 0.14404060004026065 16.062881268188214 0.07676277832094121 1.0000000000001022e-14 13.999999999999956 -3.8843931819584436 TAEAGGVTGK(ub)GQDGIGSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAEAGGVTGKGQDGIGSK 18 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 7779300.0 2825100.0 3831100.0 1123100.0 True False 2349195.823150477 3810461.1038861894 1357935.0173723174 1.0 1.6220278728301278 0.5780424960705097 21.16373554717533 -6.745311909326136 1.6671304521693406 1.367814731234184 0.5766826397828522 0.6285498609669271 0.26134322622261175 0.30831050915973107 1.6843831620876524 0.123913980040794 0.3023329027498389 1.7975794338834946e-07 6.745311909326136 -0.7911320914513318 TAEAGGVTGK(ub)GQDGIGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAEAGGVTGKGQDGIGSK 18 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 3972900.0 0.0 0.0 3972900.0 True False 0.0 0.0 3249872.965396447 0.0 TAEELMNFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAEELMNFSK 10 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 15127000.0 2387000.0 7423700.0 5316300.0 False True 3129380.115740882 6316112.897355962 4766220.2735505495 1.0 2.018327165046429 1.5230557162347613 21.577445478074736 -10.19549391498454 5.725793970696725 0.999980928478258 1.770691440640613 0.7635146872543092 0.20219372229300853 4.923358671761005e-05 6.917210458808129e-06 0.19577805992049227 0.06525774326236347 6.375380136869511e-11 10.19549391498454 0.7707105121623549 TAEELMNFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAEELMNFSK 10 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 10393000.0 2717600.0 2092100.0 5583300.0 False True 2631331.2755390345 2927486.440157375 4120866.2345903385 1.0 1.112549555189577 1.566076560902112 21.32736145959583 -6.944706066883275 0.6142301613378155 0.9950104460757023 1.707405730335868 0.9987175227253555 0.008762257305541594 0.0856839089744827 0.04531631308823344 0.008871329880184473 0.03830028002465126 1.1357792578308817e-07 6.944706066883275 0.7123952842601657 TAEELMNFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAEELMNFSK 10 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 12564100.0 2387000.0 5040900.0 5136200.0 False True 3269538.406249514 4818176.369972871 3923135.3433594317 1.0 1.47365645277732 1.1999049577948402 21.640655539597628 -10.200471563125737 4.742004005956258 0.9999455522265629 1.3367807052875518 0.6686542171397605 0.11175857984357883 6.434212417268521e-05 1.0848266458047557e-05 0.10822723514850284 0.03606992654344755 6.30272613833404e-11 10.200471563125737 0.3368351530609889 TAEELMNFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAEELMNFSK 10 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 16112100.0 5280200.0 6658100.0 4173800.0 False True 6835322.988302548 6287570.882059717 3414211.226804521 1.0 0.9198644881624156 0.49949522980074856 22.70457808017861 -6.9387407514347395 0.6711753480843337 1.0048369458112778 0.390214225318693 0.9979942817857116 0.00983052732485459 0.08834581558865881 0.0572609673047501 0.009480342150545691 0.036385659452112695 1.1514875549728155e-07 6.9387407514347395 -0.6146227204925848 down TAEELMNFSK(ub)GEENLMDAQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAEELMNFSKGEENLMDAQVK 21 1 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 14039500.0 3980000.0 6086700.0 3972800.0 True False 5217818.54237482 5178588.085770769 3561732.765788534 1.0 0.9924814448249869 0.6826095497309991 22.31501534242397 -6.912118097475329 0.8811704660695847 1.0089635861926523 0.6406927498131223 0.9916969758283053 0.013474872047882998 0.10303445942287451 0.13128717513667384 0.011148904953519456 0.03124765240487268 1.2242832352845896e-07 6.912118097475329 -0.36827083637952995 TAEELMNFSK(ub)GEENLMDAQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAEELMNFSKGEENLMDAQVK 21 1 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 31838800.0 10173000.0 13615000.0 8050800.0 True False 9850063.68341866 19051540.50128704 5942053.961177063 1.0 1.9341540434259228 0.6032503090492463 23.231701621350577 -6.718036202037361 1.7662343767837938 1.5695084630745006 0.6055282982464679 0.5033112996531641 0.3931925289540667 0.3591413076889954 2.1884629762145504 0.17682875548354013 0.4449596217148151 1.914096362606363e-07 6.718036202037361 -0.9639801648280327 TAEELMNFSK(ub)GEENLMDAQVK ddPTM_RPMI8226_Bortezomib_8h_R1 2 TAEELMNFSKGEENLMDAQVK 21 1 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 102678200.0 40944900.0 29827700.0 31905600.0 True False 62116406.773149714 24504713.89011618 25599444.175278727 1.0 0.3944966420805353 0.41212049287989855 25.888471041256594 -9.954049189440505 7.263739015437585 1.0000000150742203 0.40330856752200817 0.9993461479397704 0.007194906960231792 1.7572399979530856e-09 2.572428033313459e-10 0.006966438916237296 0.0023221462362072315 1.11160581648342e-10 9.954049189440505 -0.5966914475522122 TAEELMNFSK(ub)GEENLMDAQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAEELMNFSKGEENLMDAQVK 21 1 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 21810200.0 3980000.0 9517600.0 8312600.0 True False 5451513.5554558225 9097080.961505648 6349335.08337091 1.0 1.6687257344157893 1.164692157284752 22.37822540394686 -10.398540775991314 5.304419635888957 0.9997311939244953 1.4167089458502526 0.4768097277227348 0.2057708462001638 0.0006545448493203566 7.421754856817921e-05 0.19936311473934473 0.06641225503901552 3.9944705538776746e-11 10.398540775991314 0.41697775192575737 TAEELMNFSK(ub)GEENLMDAQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TAEELMNFSKGEENLMDAQVK 21 1 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 41535000.0 14063300.0 18806300.0 8665400.0 True False 11694257.059825188 18704986.7291417 10477295.075717274 1.0 1.5995019293189126 0.8959350749789226 23.479296873900832 -6.681053020361275 1.8984210073296326 1.3789660434176172 0.8986113609756398 0.32877655361694225 0.2540271845142948 0.4362187340111058 3.0405450469601805 0.10734118411174637 0.28269531467297027 2.0842364158678134e-07 6.681053020361275 -0.48035468244197743 TAEELMNFSK(ub)GEENLMDAQVK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TAEELMNFSKGEENLMDAQVK 21 1 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 1 89209300.0 40944900.0 24552800.0 23711600.0 True False 53003980.19464206 23186415.09635419 19396332.101561677 1.0 0.4374466787439107 0.36594104877283096 25.659597363349043 -13.999999999999998 0.2908364035067007 5.870426341505522 0.3466192116761091 0.9996293343130586 0.005459111808432557 16.015666000771187 0.1710386135690271 46.692761148002184 0.026904297920575717 1.0000000000000041e-14 13.999999999999998 -5.523807129829413 TAEEPPQEK(ub)APEPTDAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAEEPPQEKAPEPTDAR 17 1 O43719;Q5H918;Q5H919 O43719 HTATSF1 HIV Tat-specific factor 1 1 1744390.0 1043000.0 0.0 701390.0 True False 1367383.1004263677 0.0 628816.8910079597 1.0 0.0 0.45986884788314736 20.382986069512725 -10.582850938876573 5.623830651363471 1.0034717786939413 0.22993442394157632 0.7889737888427392 0.18774067098588212 0.00819250547422477 0.0006076804385483863 0.1822285225690701 0.060593041011177136 2.6130580697643847e-11 10.582850938876573 -0.773537354752365 TAEEPPQEK(ub)APEPTDAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAEEPPQEKAPEPTDAR 17 1 O43719;Q5H918;Q5H919 O43719 HTATSF1 HIV Tat-specific factor 1 1 3092900.0 0.0 1172500.0 1920400.0 True False 0.0 1640685.3645067252 1417389.6292349135 0.0 TAEEPPQEK(ub)APEPTDAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAEEPPQEKAPEPTDAR 17 1 O43719;Q5H918;Q5H919 O43719 HTATSF1 HIV Tat-specific factor 1 1 2908970.0 0.0 2129700.0 779270.0 True False 0.0 2118226.8833876476 942211.7540626167 0.0 TAEFQVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAEFQVAR 8 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 6426300.0 1914300.0 2303500.0 2208500.0 False True 2509665.838107571 1959826.7789726725 1979985.605427909 1.0 0.7809114461431614 0.7889439204866132 21.259063851508582 -9.972692727469813 4.934001579629664 1.0000017980349099 0.7849276833106507 0.9989549473191353 0.003279243935209077 6.622603576847232e-08 1.3789435675144801e-08 0.003175141389360854 0.0010583714267736008 1.0648961883241376e-10 9.972692727469813 -0.2150741147242592 TAEFQVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAEFQVAR 8 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 5140030.0 1667800.0 755730.0 2716500.0 False True 1614856.6019075636 1057496.9300798865 2004967.1567468424 1.0 0.6548550062158516 1.2415759729863676 20.622974629660128 -6.747363605534778 1.660366488506425 0.7964006708398526 1.2424575094141665 0.637232837323074 0.1450152799914404 0.3046664404044356 1.6518148026594883 0.06902998896735327 0.16800250508734746 1.789107327685091e-07 6.747363605534778 0.446056838574314 TAEFQVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAEFQVAR 8 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 17920600.0 3571700.0 11768000.0 2580900.0 False True 5418530.026246463 9667908.456196342 2070783.9837513424 1.0 1.784230854007746 0.3821671142765302 22.369470090371905 -6.75489956896069 1.6315335253699674 1.4583979880353666 0.37827276073683014 0.6698622019093077 0.32965288941115173 0.2915695257847449 1.5283830829669476 0.15951085966654718 0.38530573797732137 1.7583301825848271e-07 6.75489956896069 -1.0801252272985364 TAEFQVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAEFQVAR 8 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 6466800.0 1914300.0 2093500.0 2459000.0 False True 2622068.4420123356 2001002.2477212811 1878234.8446946866 1.0 0.7631388317940281 0.7163180085616737 21.322273913031474 -13.999999999999998 0.2279161626912556 2.480958771073729 0.6930972190718104 0.9995070180620451 0.0027570361485161747 13.227338026381034 0.15117790873484618 8.85447470259349 0.024623396135339325 1.0000000000000041e-14 13.999999999999998 -1.7878615520019188 TAEFQVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAEFQVAR 8 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 3877870.0 1667800.0 1507600.0 702470.0 False True 1386849.5960675257 1499478.2595648284 849353.229145697 1.0 1.0812118803774153 0.61243355555936 20.403379905094404 -6.862235883179448 1.1744928102264245 1.044346124569992 0.5887558095249908 0.9562946799403936 0.04276227638706945 0.1445101126220346 0.37754187657413224 0.02837211218734724 0.06639986077731103 1.3732958789888585e-07 6.862235883179448 -0.45559031504500125 TAEFQVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAEFQVAR 8 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 8185000.0 3571700.0 2381300.0 2232000.0 False True 4623636.058732663 2248778.561669068 1825798.9022539852 1.0 0.4863658240189123 0.3948837839011135 22.140596412464355 -13.999999999999998 0.24268616677314978 4.444558175214831 0.3554535082271742 0.9995294997187896 0.005776828712067379 13.71976879842005 0.15590644772925852 22.938820121686348 0.04400677574510848 1.0000000000000041e-14 13.999999999999998 -4.089104666987657 TAENATSGETLEENEAGD ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAENATSGETLEENEAGD 18 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 9209600.0 1394600.0 4062500.0 3752500.0 False True 1828334.10532561 3456390.835500975 3364227.2965217163 1.0 1.890459093572191 1.8400506158706575 20.802098298392394 -10.569848747799538 6.292115857803478 0.9982994769247792 1.8652548547214243 0.997460920715063 0.02057917484653679 0.0004915831856085129 3.3606375762268336e-05 0.01995269774758173 0.006641900121610636 2.6924723508624236e-11 10.569848747799538 0.8669553777966451 TAENATSGETLEENEAGD ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAENATSGETLEENEAGD 18 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 9431900.0 2673400.0 1410200.0 5348300.0 False True 2588534.3803451764 1973300.2140958472 3947419.7844392275 1.0 0.7623233552852062 1.5249632434523996 21.30370404920897 -6.822989367982049 1.35900985430532 0.8722659616623609 1.5426866636345211 0.8910860771489288 0.10515292380074126 0.18963393531080172 0.687382876106896 0.06079131306923722 0.1400067186288392 1.5031787651483931e-07 6.822989367982049 0.6704207019721602 TAENATSGETLEENEAGD ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAENATSGETLEENEAGD 18 0 Q9UQ80;Q9UQ80-2 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 8208200.0 1394600.0 3485100.0 3328500.0 False True 1910221.307647913 3331116.758315471 2542376.852609302 1.0 1.7438381327748511 1.3309331449871493 20.865308359915286 -10.179919229721467 4.470295089939408 0.9999068637709798 1.537385638662674 0.6931056696188823 0.1685677559423379 118266194.91747107 30.980174505435162 141148.97757543236 0.057705226410456785 6.608163354922842e-11 10.179919229721467 0.5374787748916943 TAEQSCDQK(ub)LTNTNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAEQSCDQKLTNTNR 15 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2;A0A087WWG9 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 2847580.0 643810.0 1346200.0 857570.0 True False 844041.1446649085 1145352.2074465016 768836.882792306 1.0 1.3569862259513619 0.9108997679224995 19.68695380246548 -6.69361168350044 1.8536567264539734 1.223048378814964 0.9123746506724272 0.3873271726853176 0.15087158432458106 0.40896296756646494 2.7272013154429464 0.06504601570148537 0.1686126505974349 2.0248288333383633e-07 6.69361168350044 -0.3106737281425368 TAEQSCDQK(ub)LTNTNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAEQSCDQKLTNTNR 15 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2;A0A087WWG9 A0A087WVR3 UHRF1 E3 ubiquitin-protein ligase UHRF1 1 2694370.0 643810.0 1440200.0 610360.0 True False 881843.9553110593 1376567.2018954796 466205.5387587833 1.0 1.5610099650906073 0.5286712416079727 19.750163863988373 -6.7591809359784625 1.6161102437029395 1.3262069715902713 0.525122683219008 0.687402338530848 0.23593100597901215 0.284293750793912 1.4633463583546111 0.11520846742689449 0.27702699597065644 1.74108135210813e-07 6.7591809359784625 -0.8010842883712633 TAESQTPTPSATSFFSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAESQTPTPSATSFFSGK 18 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1;A0A3B3ITG9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 4030000.0 2977900.0 1052100.0 0.0 False True 2883368.1945200493 1472209.016629021 0.0 1.0 0.5105865492402288 0.0 21.459323644273937 -7.896314186863226 0.5995195044421548 1.0089512885913867 3.180057050157368e-18 0.9887490545974824 0.04330632454083094 0.1133211803277415 0.160128870200756 0.044391388727141684 0.07729287694784973 1.269655250961324e-08 7.896314186863226 -1.0089512885913867 down TAFDDAIAELDTLNEDSYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAFDDAIAELDTLNEDSYK 19 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 10396900.0 7050600.0 0.0 3346300.0 False True 6826782.562303313 0.0 2469803.6431518383 1.0 0.0 0.36178150111149027 22.702774371109687 -10.596675682786259 6.420203050823392 1.0021082291707395 0.1808907505557592 0.8723653160948928 0.14769667935021608 0.004464084009313875 0.0002804385604335364 0.1432351416082086 0.0476688982844603 2.531187500629028e-11 10.596675682786259 -0.8212174786149803 TAFDDAIAELDTLNEDSYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAFDDAIAELDTLNEDSYK 19 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 8679700.0 7050600.0 0.0 1629100.0 False True 5862886.294539929 0.0 1969737.2778926578 1.0 0.0 0.3359671634305892 22.483179646543963 -10.523380343818 6.217845974936924 1.0009048660323527 0.16798358171531674 0.8910352510496894 0.1371580201225314 0.0017220514078023854 0.00013200105702763698 0.13292468191576912 0.044267560644445474 2.996537080228453e-11 10.523380343818 -0.8329212843170359 TAFGIISTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAFGIISTVK 10 0 P78346;P78346-2;Q5VU10 P78346 RPP30 Ribonuclease P protein subunit p30 0 9781300.0 2511500.0 2507800.0 4762000.0 False True 3292600.8214005954 2133646.015327834 4269273.920329501 1.0 0.6480123559041788 1.296626634051999 21.650796186664788 -6.75932017629159 1.6148935390039643 0.7953724746140418 1.298927317136153 0.6882218940995547 0.14803362008549237 0.2840699739338966 1.4599097357130133 0.07232972222969167 0.17394599455095044 1.7405232288437488e-07 6.75932017629159 0.5035548425221112 TAFGIISTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAFGIISTVK 10 0 P78346;P78346-2;Q5VU10 P78346 RPP30 Ribonuclease P protein subunit p30 0 5448200.0 2213700.0 1696900.0 1537600.0 False True 1840789.6335380038 1687758.4628917228 1859105.0509408582 1.0 0.9168665621219549 1.0099497612704675 20.811893333441326 -11.162010855440016 10.34301047918491 2.734060334361435 0.963408161696102 0.17084435799587694 0.03800105692328758 0.04531395348912145 0.0007097900870692863 0.0010972506824052204 0.012264788383514398 6.886350832997211e-12 11.162010855440016 -1.7706521726653328 TAFQEALDAAGDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAFQEALDAAGDK 13 0 P10599;P10599-2 P10599 TXN Thioredoxin 0 72045300.0 7814300.0 35841000.0 28390000.0 False True 10244622.973788835 30493662.50712379 25452475.136109676 1.0 2.9765529278278673 2.4844716297740357 23.288363554968306 -10.353068421055825 5.82371482688522 0.999704450889531 2.7305122788009553 0.9428236930686578 0.20089134869972936 0.0007710098035289359 8.564806502773851e-05 0.194542340921471 0.0648374039925978 4.4353876097813664e-11 10.353068421055825 1.7308078279114243 TAFQEALDAAGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAFQEALDAAGDK 13 0 P10599;P10599-2 P10599 TXN Thioredoxin 0 72475000.0 31561000.0 12000000.0 28914000.0 False True 30559113.330618 16791662.579173323 21340555.998593137 1.0 0.5494813412125181 0.6983368845722188 24.865099348551233 -10.407285941440723 5.0984269162604345 1.0003575884646387 0.623909112892345 0.8948615610338166 0.06077002110274912 0.0002472383296928255 2.8742515752596613e-05 0.058895216073921015 0.019613439973289962 3.914840373842281e-11 10.407285941440723 -0.3764484755722938 TAFQEALDAAGDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAFQEALDAAGDK 13 0 P10599;P10599-2 P10599 TXN Thioredoxin 0 153832000.0 18012000.0 135820000.0 0.0 False True 27325520.853585526 111581859.83349639 0.0 1.0 4.083430300610543 0.0 24.70374565967773 -6.704760889126117 1.8139537179868603 2.9057753027027 0.011105721006770977 0.4400301045141727 1.3004730398444384 0.38578087094290525 2.471035777477322 0.5712532361140809 1.4605065937949744 1.9735089980876965e-07 6.704760889126117 -2.894669581695929 TAFQEALDAAGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAFQEALDAAGDK 13 0 P10599;P10599-2 P10599 TXN Thioredoxin 0 72385300.0 7814300.0 40279000.0 24292000.0 False True 10703457.883517196 38499340.595159 18554729.90944421 1.0 3.5969068140536256 1.7335266893531285 23.351573616491198 -6.560158454610824 2.3450389501567352 2.788905341745637 1.7364038436089808 0.0 1.1337885451780396 0.7609939403174774 7.84241443870986 0.4111717560609992 1.2758798563767602 2.753223991903714e-07 6.560158454610824 -1.052501498136656 TAFQEALDAAGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAFQEALDAAGDK 13 0 P10599;P10599-2 P10599 TXN Thioredoxin 0 44563800.0 31561000.0 7763600.0 5239200.0 False True 26244369.88936758 7721775.945846061 6334692.49667621 1.0 0.29422599888650386 0.24137338878319167 24.64550462398551 -13.907611230828078 0.36835504144167136 9.999999995701383 0.23570544392049925 0.9997858590550892 0.005060811276001145 21.082979078152366 0.1966094037242915 149.2917061569193 0.014854645816144417 1.2370543169285456e-14 13.907611230828078 -9.764294551780884 TAFQEALDAAGDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAFQEALDAAGDK 13 0 P10599;P10599-2 P10599 TXN Thioredoxin 0 30864000.0 18012000.0 12852000.0 0.0 False True 23316889.06960071 12136774.90218404 0.0 1.0 0.5205143304475941 0.0 24.47487198177018 -7.866673693323045 0.6058240850597683 1.007521079227426 5.699796937234234e-18 0.9885267172740348 0.0437411331630004 0.11432726758347266 0.1587868325963413 0.04402538765247806 0.07751745577296275 1.3593343973847524e-08 7.866673693323045 -1.007521079227426 down TAFQEALDAAGDKLVVVDFSATWCGPCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAFQEALDAAGDKLVVVDFSATWCGPCK 28 1 P10599;P10599-2 P10599 TXN Thioredoxin 0 125658000.0 29468000.0 51956000.0 44234000.0 False True 44705110.39937033 42684045.86591922 35491130.511549026 1.0 0.9547911969035294 0.7938942593920744 25.41393642462259 -6.947560871469181 0.5850121956398721 1.0018893242683822 0.7387691365746271 0.9989956780187678 0.0028030787247502772 0.08448027605125165 0.040132115818245356 0.0029212084536146127 0.013459473674342474 1.1283377766606768e-07 6.947560871469181 -0.2631201876937551 TAFTSQQLLELEHQFK(ub)LNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAFTSQQLLELEHQFKLNK 19 1 P50219;P50219-2;C9K088 P50219 MNX1 Motor neuron and pancreas homeobox protein 1 1 48021100.0 3587000.0 4715100.0 39719000.0 True False 4643442.21034075 4452700.540093991 32490549.551355734 1.0 0.9589223550964011 6.9970827846205665 22.146763249385856 -6.905365921347354 0.9267014779032249 0.7845592619231131 7.7047867755676815 0.989052513025994 0.29681334668897935 0.10756319207042299 0.15597417524193724 0.2375693177534253 0.6365491881868972 1.2434664688944842e-07 6.905365921347354 6.920227513644568 up TAGINVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAGINVR 7 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 9016200.0 2396100.0 4274700.0 2345400.0 False True 3141310.3038654095 3636931.422650092 2102720.5066654324 1.0 1.157775281918127 0.6693768852055197 21.58293503117304 -6.8197427827304375 1.3729672149090026 1.085062088918086 0.6587715159228262 0.8837963054942695 0.06937298140854076 0.19381492845388296 0.7179571332475647 0.039706627434951305 0.09152459095918893 1.5144579427740746e-07 6.8197427827304375 -0.42629057299525974 TAGINVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAGINVR 7 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 6304600.0 2136600.0 1850100.0 2317900.0 False True 2068774.8025157126 2588854.5781440423 1710772.4544905256 1.0 1.2513950648450918 0.826949580210547 20.98034517780085 -6.746241451941047 1.6638486147504676 1.1484882649266912 0.8263465532135218 0.6326100995727297 0.10562387216033468 0.3066429806397397 1.6690220024844662 0.05017470633774732 0.12229072834030455 1.7937360975130016e-07 6.746241451941047 -0.3221417117131694 TAGINVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAGINVR 7 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 18424900.0 3697900.0 11173000.0 3554000.0 False True 5609984.652702297 9179090.854952546 2851550.342226463 1.0 1.6362060545978554 0.5082991342681994 22.419565393366696 -6.753667391404233 1.6361503763602403 1.3724477380574547 0.5054027709978269 0.6645964229381687 0.2674030421280623 0.2937181713990142 1.5480400987082967 0.12904349673322824 0.31210107402421555 1.763325989539369e-07 6.753667391404233 -0.8670449670596277 TAGINVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAGINVR 7 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 7892000.0 2396100.0 2794100.0 2701800.0 False True 3282002.922167769 2670647.4231468965 2063690.4853176512 1.0 0.8137248766929582 0.6287899597464647 21.64614509269593 -6.97121451873749 0.2273179126705919 1.077781562490295 0.35946607466608405 0.9999903660906643 0.00047034181777984226 0.07591056966120029 0.007605005211378643 0.004847184981889747 0.01846472521711684 1.0685269524752528e-07 6.97121451873749 -0.7183154878242111 TAGINVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAGINVR 7 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 5057220.0 2136600.0 2000400.0 920220.0 False True 1776677.5674288762 1989623.4481516902 1112633.7473834513 1.0 1.1198562331323738 0.6262440455043299 20.760750453235126 -6.842545300113286 1.2705301729864915 1.0637542748785815 0.6091741549861592 0.928742012366286 0.05611511784902482 0.16584612609627158 0.5189394517709441 0.034617165065994285 0.0798136863689855 1.436993156568364e-07 6.842545300113286 -0.4545801198924223 TAGINVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAGINVR 7 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 11112100.0 3697900.0 2493600.0 4920600.0 False True 4787004.446506569 2354828.9679494333 4025101.289619605 1.0 0.4919211992100667 0.8408392627579485 22.190691715459145 -10.121198387624887 5.635917325875005 1.000003718763367 0.6663802309839678 0.5493418085675865 0.14244520295553537 6.656006926045745e-06 1.0380298180609402e-06 0.13792351064192368 0.04597399156613832 7.564872493860062e-11 10.121198387624887 -0.3336234877793992 TAGRRTYHTRSQGDNNVSLVEEFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAGRRTYHTRSQGDNNVSLVEEFR 24 3 Q6JHV3;H0YMI4;Q9Y6I4;H0YLB7;H0YKU8;Q9Y6I4-2 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 0 53303000.0 14877000.0 12911000.0 25515000.0 False True 19503891.069072936 10984729.126683814 22874952.55716232 1.0 0.5632070589289824 1.1728404591755965 24.217258637727586 -6.714373769870172 1.7795305733554971 0.7326804087005372 1.1716068844742358 0.48589887738384485 0.1839413231914515 0.36634428457666895 2.264009101377783 0.08217395961801299 0.20766731308017597 1.9303063090285722e-07 6.714373769870172 0.4389264757736986 TAGRRTYHTRSQGDNNVSLVEEFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAGRRTYHTRSQGDNNVSLVEEFR 24 3 Q6JHV3;H0YMI4;Q9Y6I4;H0YLB7;H0YKU8;Q9Y6I4-2 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 0 116316000.0 24692000.0 29230000.0 62394000.0 False True 23908165.97571747 40901691.432436354 46051139.6201224 1.0 1.7107833145369036 1.9261678067190362 24.511000127626982 -10.915611203001081 0.23413507749797874 2.8171203937767795e-10 2.0490717696333323 0.9992541854892396 0.01080711374310183 2.8494245489882393 0.12467691364264533 1.6637343211960165 0.1076265229971981 1.2144756088649331e-11 10.915611203001081 2.0490717693516203 TAGRRTYHTRSQGDNNVSLVEEFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAGRRTYHTRSQGDNNVSLVEEFR 24 3 Q6JHV3;H0YMI4;Q9Y6I4;H0YLB7;H0YKU8;Q9Y6I4-2 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 0 282813000.0 20040000.0 70303000.0 192470000.0 False True 30402145.120245058 57756880.370153844 154428220.1374022 1.0 1.899763327282226 5.079517235596875 24.857669785418455 -6.947722331996025 0.5833132979836798 0.962444038314136 6.17500999134191 0.9990102075770266 0.05505706072536307 0.08441343568887606 0.039848364384376216 0.05748071006858362 0.26586712452159655 1.1279183650444603e-07 6.947722331996025 5.212565953027774 TAGRRTYHTRSQGDNNVSLVEEFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAGRRTYHTRSQGDNNVSLVEEFR 24 3 Q6JHV3;H0YMI4;Q9Y6I4;H0YLB7;H0YKU8;Q9Y6I4-2 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 0 76034000.0 14877000.0 19184000.0 41973000.0 False True 20377428.935808133 18336387.446995478 32059841.861069582 1.0 0.8998381250528595 1.5733016153344346 24.280468699250477 -6.869054272162349 1.1390247726053704 0.943658259589696 1.6120509175782882 0.9637334043199102 0.056502291635809554 0.13776817287211102 0.33463947596171484 0.03851831433450813 0.09105115141017255 1.3519036102835236e-07 6.869054272162349 0.6683926579885923 TAGRRTYHTRSQGDNNVSLVEEFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAGRRTYHTRSQGDNNVSLVEEFR 24 3 Q6JHV3;H0YMI4;Q9Y6I4;H0YLB7;H0YKU8;Q9Y6I4-2 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 0 109335000.0 24692000.0 35644000.0 48999000.0 False True 20532492.041071698 35451978.69721997 59244464.35422148 1.0 1.7266281475382734 2.8854005756200065 24.29140540306126 -6.964219825553542 0.3712030045492188 0.9120960236826029 3.7403438767228567 0.9998961426567428 0.007912545327169106 0.0782267612650414 0.015799877712227343 0.015246130484800459 0.09835060379615455 1.0858758499225062e-07 6.964219825553542 2.8282478530402537 TAGRRTYHTRSQGDNNVSLVEEFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAGRRTYHTRSQGDNNVSLVEEFR 24 3 Q6JHV3;H0YMI4;Q9Y6I4;H0YLB7;H0YKU8;Q9Y6I4-2 Q6JHV3 USP3 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 3 0 273549000.0 20040000.0 69909000.0 183600000.0 False True 25942175.04745715 66018502.69505004 150186683.8950861 1.0 2.5448329823647984 5.789286504325218 24.628796107510905 -6.95907749590685 0.4482453056485229 0.8934762601990618 7.568887409786689 0.9997344411326377 0.03252409744863387 0.08003231125623766 0.022361408102194825 0.043253848182109554 0.26844141750021244 1.098809749315348e-07 6.95907749590685 6.675411149587627 TAGTICLETFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAGTICLETFK 11 0 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 65869000.0 19974000.0 22519000.0 23376000.0 False True 26186107.428491175 19159252.978374496 20957275.758425504 1.0 0.7316571594573359 0.8003203918587547 24.64229828285438 -10.25845307554892 6.567849795812771 1.0000031540449068 0.7659887756580455 0.9393456672277453 0.02803164724560229 1.2946359933692929e-06 1.461304115982378e-07 0.02714189169718488 0.009047175245748197 5.515017875749796e-11 10.25845307554892 -0.23401437838686134 TAGTICLETFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAGTICLETFK 11 0 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 15244100.0 10919000.0 4325100.0 0.0 False True 10572382.32175841 6052134.985098532 0.0 1.0 0.5724476093380565 0.0 23.333797166431133 -7.7220450669207565 0.6410559626644411 1.0011391308094257 4.189521310401958e-19 0.9875938549046795 0.0456307018049821 0.1195420927769148 0.15213294911546837 0.042908171359871336 0.07790606704521326 1.8965091094530314e-08 7.7220450669207565 -1.0011391308094257 down TAGTICLETFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAGTICLETFK 11 0 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 93912000.0 21569000.0 46308000.0 26035000.0 False True 32721749.905118056 38043975.59394455 20889170.838454142 1.0 1.162651010543725 0.6383879498812145 24.963746567501268 -6.823391091953329 1.357296492044758 1.087380010742901 0.6261044466230679 0.8919630704539173 0.07201817458702454 0.18911994639073954 0.683679607901673 0.041687062899480855 0.0959985996439731 1.5017889622229168e-07 6.823391091953329 -0.46127556411983317 TAGTICLETFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAGTICLETFK 11 0 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 41586000.0 19974000.0 21612000.0 0.0 False True 27358927.57705398 20657110.378673192 0.0 1.0 0.7550409393969951 0.0 24.70550834437727 -7.325313183456883 0.8027265565336491 0.9891535562054403 7.284529376952432e-16 0.9880395057959835 0.046543531319813966 0.10650209043577673 0.13760050330322834 0.03982498278732195 0.07068914597034714 4.7281017765340114e-08 7.325313183456883 -0.9891535562054395 down TAGTICLETFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAGTICLETFK 11 0 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 14905700.0 10919000.0 3986700.0 0.0 False True 9079632.293717055 3965222.8558020038 0.0 1.0 0.4367162377870597 0.0 23.11420244186541 -8.140772935983431 0.5563597647467509 1.0226680182974097 2.000343719872923e-16 0.9907329852312523 0.03940494551297697 0.12009304252162081 0.170664495823564 0.0509326959472362 0.07407458797173294 7.231477911922769e-09 8.140772935983431 -1.0226680182974095 TAGTICLETFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAGTICLETFK 11 0 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 62809000.0 21569000.0 22818000.0 18422000.0 False True 27921495.688553065 21548158.24136596 15069385.025682297 1.0 0.7717408294212559 0.5397055083929573 24.734872889593717 -6.970920828943653 0.23515689482513516 1.0884855313275108 0.21628936450115863 0.9999886994698834 0.0006316787878269658 0.07600506241326557 0.007953184207941036 0.0057419333073873225 0.022821165764433084 1.0692497836544865e-07 6.970920828943653 -0.8721961668263521 TAGTICLETFKDFPQMGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAGTICLETFKDFPQMGR 18 1 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 38007100.0 5255100.0 22441000.0 10311000.0 False True 7972370.899271434 18436228.21766673 8273026.330528148 1.0 2.3125151163440663 1.037712173085699 22.926577399683314 -6.639335982570688 2.0463856692417823 1.8587121516108682 1.0429515527927382 0.1522593162637188 0.5616728571729811 0.5350276498847526 4.281149692658058 0.22355240952981212 0.6221344480521653 2.2943729691190755e-07 6.639335982570688 -0.81576059881813 TAGTICLETFKDFPQMGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAGTICLETFKDFPQMGR 18 1 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 4608400.0 1639300.0 0.0 2969100.0 False True 2245393.510416767 0.0 2267859.730533954 1.0 0.0 1.0100054712071458 21.0985368720978 -12.05171526102168 14.504085686879469 0.8794408621637317 0.5545024620432276 0.0 0.4876556257903492 0.0 0.0 0.0 0.14005202448319856 8.877378539320872e-13 12.05171526102168 -0.3249384001205041 TAGTICLETFKDFPQMGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAGTICLETFKDFPQMGR 18 1 P15170-2;P15170-3;P15170;H3BR35;Q8IYD1 P15170-2;Q8IYD1 GSPT1;GSPT2 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A;Eukaryotic peptide chain release factor GTP-binding subunit ERF3B 0 20981700.0 5255100.0 8872700.0 6853900.0 False True 6802830.543507577 8378926.445269864 5606560.526952781 1.0 1.2316823698139103 0.8241511369562952 22.697703721775763 -6.752466535906508 1.6404633160018778 1.1358245426256988 0.8231734701754826 0.659619659523331 0.09736926770682712 0.2957616101725341 1.5666730805453133 0.04687073148513712 0.11350767170340431 1.768208459883464e-07 6.752466535906508 -0.31265107245021617 TAGYPNVNIHNFTTSWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAGYPNVNIHNFTTSWR 17 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 36063000.0 10088000.0 10840000.0 15135000.0 False True 13225465.692330964 9222714.253989045 13568975.385171564 1.0 0.6973451422082634 1.0259733532891617 23.65681518732118 -11.894476909920003 13.459054806975093 0.9028961137566887 0.8754933229783045 0.0 0.15262473200305196 0.0 0.0 0.0 0.044435546423714015 1.275037887920388e-12 11.894476909920003 -0.027402790778384145 TAGYPNVNIHNFTTSWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAGYPNVNIHNFTTSWR 17 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 27289300.0 6386000.0 12374000.0 8529300.0 False True 9688028.879135981 10165763.021496726 6843480.1164750075 1.0 1.0493117999874657 0.7063851895830989 23.20777173490598 -6.870415140075202 1.1318221633996204 1.0279635544829036 0.6861361092834345 0.9650995838973541 0.028280068565686416 0.13646135558107106 0.32645542951452533 0.01938554457827405 0.04593203394481514 1.347674031348258e-07 6.870415140075202 -0.34182744519946906 TAGYPNVNIHNFTTSWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAGYPNVNIHNFTTSWR 17 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 34563000.0 10088000.0 11264000.0 13211000.0 False True 13817806.217949344 10766319.234933134 10090833.88908561 1.0 0.7791627024663057 0.7302775657671047 23.72002524884407 -13.999999999999998 0.21190157831463524 2.2872687938262235 0.7020094824606191 0.9994911624113965 0.0026467860489527515 12.791884841567766 0.14589100352414197 6.8620273595997885 0.028576151333548117 1.0000000000000041e-14 13.999999999999998 -1.5852593113656044 TAGYPNVNIHNFTTSWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAGYPNVNIHNFTTSWR 17 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 23221900.0 8022500.0 8370100.0 6829300.0 False True 6671064.207010264 8325008.609965228 8257275.0548844775 1.0 1.2479281193571667 1.237774783550629 22.669485496207436 -10.381951567006054 5.673423911460891 0.9999243442179853 1.2428514514537066 0.998690729996765 0.004145081985530442 3.968304176803297e-06 4.323034802297353e-07 0.00401470486485164 0.0013378194582177813 4.150003213419215e-11 10.381951567006054 0.2429271072357213 TAGYPNVNIHNFTTSWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAGYPNVNIHNFTTSWR 17 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 31721000.0 6386000.0 14451000.0 10884000.0 False True 8266802.886879315 13646789.146550082 8903223.679270782 1.0 1.6507940655279965 1.0769851175962553 22.97889805699843 -10.152451030716438 5.092132446786364 0.9999824155074554 1.3638895915625922 0.349051757738049 0.234256522047628 4.676835310210021e-05 7.78442667247572e-06 0.2268288536600978 0.07560596738567775 7.039615993150799e-11 10.152451030716438 0.3639071760551368 TAHSSLALFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAHSSLALFR 10 0 Q8WW59 Q8WW59 SPRYD4 SPRY domain-containing protein 4 0 12086600.0 2602400.0 2405800.0 7078400.0 False True 3411771.6016774457 2046864.0177349513 6345995.068807293 1.0 0.5999416891589642 1.8600292779526022 21.702089639146728 -6.821316387555409 1.3660703415794468 0.7846439010660927 1.8883421767899198 0.8873885836224151 0.1764221250846238 0.19178866411574177 0.7028890835739748 0.10147319486939764 0.23381266001322068 1.5089804473972942e-07 6.821316387555409 1.103698275723827 TAHSSLALFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAHSSLALFR 10 0 Q8WW59 Q8WW59 SPRYD4 SPRY domain-containing protein 4 0 6772470.0 2330900.0 718770.0 3722800.0 False True 2256906.855370156 1005778.6093360321 2747686.9983939454 1.0 0.44564471366766883 1.2174569773918722 21.105915447726098 -6.713905120046455 1.7809740812349781 0.6605727169017921 1.215886903695181 0.48379038663753915 0.23346415451071287 0.36726884842418017 2.273081802427982 0.10421892177145133 0.26354958888476687 1.9323904386337496e-07 6.713905120046455 0.5553141867933888 TAHSSLALFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAHSSLALFR 10 0 Q8WW59 Q8WW59 SPRYD4 SPRY domain-containing protein 4 0 14320100.0 2602400.0 2766500.0 8951200.0 False True 3564577.607215637 2644266.882407893 6837110.915750755 1.0 0.741817733763239 1.91807043334129 21.76529970066962 -6.849170422237178 1.2390528012132938 0.8623149935469069 1.9643546918848764 0.9390961226607963 0.12456929057777286 0.15836994179888453 0.46829152853302325 0.0786852681639215 0.18199238708337523 1.4152383149016403e-07 6.849170422237178 1.1020396983379697 TAHSSLALFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAHSSLALFR 10 0 Q8WW59 Q8WW59 SPRYD4 SPRY domain-containing protein 4 0 4583000.0 2330900.0 2252100.0 0.0 False True 1938246.626378343 2239967.4902931503 0.0 1.0 1.1556669103965265 0.0 20.886320723160374 -6.933689845522842 1.233364757177706 1.0837625151230983 1.6863132289540817e-21 0.9656974222842389 0.0948373816828755 0.11508405665434149 0.34935302363387166 0.06356098052679103 0.12252700455593599 1.1649576951859706e-07 6.933689845522842 -1.0837625151230983 down TAICNLILGNPPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAICNLILGNPPSK 14 0 Q9NRX1 Q9NRX1 PNO1 RNA-binding protein PNO1 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 TAIGALK(ub)LNIGDLQVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAIGALKLNIGDLQVTK 17 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 11173700.0 5506300.0 2023500.0 3643900.0 True False 5331505.520496241 2831494.102413096 2689453.275343209 1.0 0.5310871556876019 0.5044453700749207 22.346111550762156 -13.999999999999998 0.4083964485835166 9.343664019817448 0.5031840364665383 0.9998493006437313 0.002793846991248859 28.052092039893907 0.21165048317926718 208.04253934451037 0.0066636501452214305 1.0000000000000041e-14 13.999999999999998 -8.84047998335091 TAIGALK(ub)LNIGDLQVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAIGALKLNIGDLQVTK 17 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 28064400.0 7192200.0 9801200.0 11071000.0 True False 10911093.220250826 8052099.282874874 8882811.997408329 1.0 0.7379736494167511 0.8141083407592891 23.37929232173191 -10.056574427033729 6.839095041290172 1.0000000790662917 0.7760409950880199 0.9202390933971306 0.031081857585585747 3.74800934799356e-08 5.147354010164711e-09 0.030094889738039473 0.01003162639984691 8.778606312091915e-11 10.056574427033729 -0.2239590839782718 TAIGALK(ub)LNIGDLQVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAIGALKLNIGDLQVTK 17 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 11192600.0 5506300.0 2901700.0 2784600.0 True False 4578732.42045007 2886067.9661576482 3366846.9854642963 1.0 0.6303202941642875 0.7353229401279032 22.126516826196433 -10.279228150184158 8.11217881423704 1.0000004511006475 0.6828216171460961 0.9240463979722257 0.04286715070882837 3.497610396893287e-07 3.1030480876563277e-08 0.04150599957048016 0.013835313399554653 5.257410035696691e-11 10.279228150184158 -0.3171788339545514 TAIGALK(ub)LNIGDLQVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAIGALKLNIGDLQVTK 17 1 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 22822000.0 7192200.0 6797600.0 8832200.0 True False 9310444.679457154 6419307.584429364 7224830.226024936 1.0 0.6894737905046703 0.7759919611536943 23.15041864382436 -10.056013426802508 6.985677666535445 1.0000000680079402 0.7327328758291825 0.927133622255608 0.03532089526152527 3.742504466411888e-08 5.033594452172979e-09 0.03419931844357602 0.011399769926751917 8.789953410785256e-11 10.056013426802508 -0.2672671921787577 TAIGK(ub)AGYTDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAIGKAGYTDK 11 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 6608600.0 2304200.0 2237800.0 2066600.0 True False 3020828.51390454 1903928.962876082 1852768.05622699 1.0 0.6302671449612275 0.6133310936714558 21.526512856944606 TAIGK(ub)AGYTDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAIGKAGYTDK 11 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 13710200.0 3719400.0 3673300.0 6317500.0 True False 3601329.682896625 5140067.84600644 4662757.229062462 1.0 1.4272694528405896 1.2947321238615703 21.78009824608329 -10.093578996820344 4.860010847801281 0.9999857999365779 1.3610007883539361 0.9081884402212801 0.05410813798818571 8.325509582103091e-06 1.5527875829997717e-06 0.05239203901582831 0.017463326442141228 8.061595500936187e-11 10.093578996820344 0.36101498841735824 TAIGK(ub)AGYTDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAIGKAGYTDK 11 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 67647500.0 4934500.0 7857000.0 54856000.0 True False 7485997.260271907 6454856.96297881 44013687.555761084 1.0 0.8622574572975941 5.879468830337565 22.83576308956407 -6.900589544593981 0.957555030338709 0.794763705941959 6.41241996561096 0.9868567249223531 0.26750459015884337 0.11097190579586742 0.1749918507301407 0.20929319947569985 0.5461603985521711 1.2572176094274962e-07 6.900589544593981 5.617656259669001 up TAIGK(ub)AGYTDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAIGKAGYTDK 11 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 8337000.0 2304200.0 3052100.0 2980700.0 True False 3156125.008663647 2917248.1300549917 2276720.0494434526 1.0 0.9243132391927025 0.7213656123232748 21.589722918467498 -6.953943601121894 0.5137289722580053 1.0036234826513697 0.633094950778687 0.9994755233259806 0.0026941299427301864 0.08193977955472005 0.029699914545813277 0.0030835045706880514 0.016754282799191302 1.1118761097137924e-07 6.953943601121894 -0.37052853187268264 TAIGK(ub)AGYTDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAIGKAGYTDK 11 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 15228500.0 3719400.0 6994100.0 4515000.0 True False 3092845.8973579286 6956421.395079853 5459065.624998672 1.0 2.24919754360293 1.7650622779693268 21.560503521517568 -10.347083830118082 5.32715875213586 0.9996651136847291 2.007129910786165 0.8522896499156403 0.19764739454831576 0.000786362481688445 9.637982426959966e-05 0.19143162516225012 0.06379042229222413 4.496930440745461e-11 10.347083830118082 1.007464797101436 TAIGK(ub)AGYTDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAIGKAGYTDK 11 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 60200500.0 4934500.0 10730000.0 44536000.0 True False 6387807.523536782 10132866.067571957 36430904.97794957 1.0 1.5862823089512288 5.70319391179442 22.60688941165652 -6.932604946838804 0.7250903286593489 0.9430450216976627 6.607317732182023 0.9970259088987221 0.11412323879257336 0.09130764700123732 0.07121795678928279 0.10563201977081016 0.36731952748236063 1.1678714807535836e-07 6.932604946838804 5.66427271048436 up TAIHEVMEQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAIHEVMEQGR 11 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 10150700.0 2281400.0 3919200.0 3950100.0 False True 2990937.493109027 3334470.636921944 3541381.544034764 1.0 1.1148580151221483 1.1840372967318553 21.51216632955612 -13.999999999972742 0.051132212898058235 0.18374123373015486 1.5734784524418988 0.9999735655177543 0.00039019531120393976 12.553081405624448 0.05435540013083801 1.4288027036557411 0.3718877615607817 1.0000000000627643e-14 13.999999999972742 1.3897372187117438 TAIHEVMEQGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAIHEVMEQGR 11 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 9814300.0 2537500.0 2111000.0 5165800.0 False True 2456948.451457274 2953933.308719571 3812722.009321867 1.0 1.2022772830123984 1.551811967019679 21.22843615856389 -6.962799609487854 0.3939959560228509 0.979465870334834 1.787263324153799 0.9998603572899326 0.0026935070428383448 0.07871579000354512 0.017543950432451362 0.004504356649171631 0.029353616373657944 1.0894326592628621e-07 6.962799609487854 0.807797453818965 TAIHEVMEQGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAIHEVMEQGR 11 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 32553400.0 5659100.0 23138000.0 3756300.0 False True 8585268.435627675 19008843.121980872 3013865.658555223 1.0 2.2141233281765316 0.3510508356440083 23.033431813009287 -6.73081569804542 1.7199719913568672 1.7299766385084154 0.3519344501330519 0.5631639961884796 0.5103571474214199 0.3347137649489335 1.9401799506469417 0.23509228101414978 0.5828908217887236 1.8585930206123633e-07 6.73081569804542 -1.3780421883753635 TAIHEVMEQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAIHEVMEQGR 11 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 8805200.0 2281400.0 3603500.0 2920300.0 False True 3124895.232516816 3444285.454819024 2230585.2854664084 1.0 1.102208297730663 0.7138112222949238 21.57537639107901 -6.83674881926094 1.2972854811623993 1.0544180974643984 0.7018277960572274 0.9187351471720537 0.04686131167920392 0.17263351895572188 0.5657438013092364 0.028338030526540745 0.06524385796770303 1.4563011106869947e-07 6.83674881926094 -0.35259030140717096 TAIHEVMEQGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAIHEVMEQGR 11 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 6978500.0 2537500.0 2779700.0 1661300.0 False True 2110043.6803101962 2764725.2043727473 2008670.149016677 1.0 1.3102691807623181 0.951956666945105 21.008841433998168 -6.677681216127166 1.9099650468596125 1.196716688249694 0.95333904683722 0.3135993715458488 0.13156643219223013 0.44370406236285365 3.1273456747407056 0.055312360420747754 0.14632604863262436 2.1004811277439782e-07 6.677681216127166 -0.24337764141247398 TAIHEVMEQGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAIHEVMEQGR 11 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 14014800.0 5659100.0 4321700.0 4034000.0 False True 7325816.507538152 4081193.595920383 3299853.3923353828 1.0 0.5570974364046517 0.4504417205836216 22.804558135101736 -13.999999999999998 0.19998636526790156 3.4619063444098415 0.38116533055816926 0.9994869287253967 0.0053896651343323995 12.530625641564626 0.14179943713105272 12.066890871476353 0.0679196764837138 1.0000000000000041e-14 13.999999999999998 -3.0807410138516724 TAIHEVMEQQTISIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAIHEVMEQQTISIAK 16 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 32810700.0 4055900.0 24065000.0 4689800.0 False True 6153096.826008081 19770412.72929678 3762858.9743876397 1.0 3.2130833120861433 0.6115390478632942 22.552881264496378 -6.68136641340705 1.897222683363192 2.398526105138076 0.6213753938889828 0.3303393876506642 0.9376779802722078 0.4354750883548612 3.03177495116017 0.39642841760582787 1.0436538838107192 2.082732943895391e-07 6.68136641340705 -1.7771507112490932 TAIHEVMEQQTISIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAIHEVMEQQTISIAK 16 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 15128800.0 4055900.0 5838700.0 5234200.0 False True 5250442.50374159 5513771.2123702075 4281629.307427335 1.0 1.0501536219929963 0.8154797056393139 22.324007586588827 -6.850810321880637 1.2310919244315321 1.026785137403697 0.8059467420405461 0.9414812020243895 0.0244093973765026 0.1565740678395741 0.4562279405848763 0.015511079160319186 0.03591442669865908 1.4099044397497292e-07 6.850810321880637 -0.22083839536315086 TAIHEVMEQQTISIAK(ub)AGILTTLNAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAIHEVMEQQTISIAKAGILTTLNAR 26 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 139662400.0 8292400.0 23121000.0 108249000.0 True False 12580177.055644698 18994876.904802468 86853537.70277773 1.0 1.5099053710281054 6.903999627239486 23.58464889131769 -6.925293540652819 0.7844534614040088 0.9021125246891858 7.88942036478977 0.9955298059289988 0.17858911977676584 0.09515614596920238 0.09019684126531254 0.15835851577514762 0.5012937682228028 1.1876991874295345e-07 6.925293540652819 6.987307840100584 up TAIHEVMEQQTISIAK(ub)AGILTTLNAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAIHEVMEQQTISIAKAGILTTLNAR 26 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 25953200.0 9978300.0 9919800.0 6055100.0 True False 8297398.56364108 9866360.068473872 7321193.414380846 1.0 1.1890907725835815 0.8823480465868022 22.984227656673667 -6.739946909202669 1.686992973325469 1.1125166323834663 0.8821742447973321 0.6046457830765257 0.07944796733196932 0.31791978566605394 1.7765462473232962 0.037257439915862466 0.09142811208641378 1.8199233235014608e-07 6.739946909202669 -0.23034238758613423 TAIHEVMEQQTISIAK(ub)AGILTTLNAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAIHEVMEQQTISIAKAGILTTLNAR 26 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 1 131142400.0 8292400.0 23654000.0 99196000.0 True False 10734675.267641386 22337634.10646287 81143345.83691141 1.0 2.0808858721416055 7.55899399039205 23.35577521341014 -6.939503596418519 0.6641655795634015 0.9379536052639211 9.014939830770665 0.9980981563078056 0.12521702500702822 0.08799382807459988 0.055646435350655846 0.12143573702641319 0.47253040618688896 1.1494667245778862e-07 6.939503596418519 8.076986225506744 TAK(ub)CLEALGINSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAKCLEALGINSVR 14 1 J3KSW2;Q9UNA4;X6R2I3;J3KQ09;J3KTN3 J3KSW2 POLI DNA polymerase iota 1 5142230.0 995730.0 1956100.0 2190400.0 True False 1363878.2895914665 1869673.0340423184 1673072.6327040452 1.0 1.3708503524917584 1.2267022984911609 20.379283475535733 -10.197222798470403 5.335402704204947 0.9999844329424908 1.2987763254915254 0.851370484678556 0.05884819661966733 1.0897638076576852e-05 1.639602162008076e-06 0.05698248771478112 0.01899317378849261 6.350050827717509e-11 10.197222798470403 0.2987918925490346 TAK(ub)EVQTIEVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAKEVQTIEVYK 12 1 Q86W42;Q86W42-2;Q86W42-3 Q86W42 THOC6 THO complex subunit 6 homolog 1 5776400.0 800330.0 520470.0 4455600.0 True False 774923.9622284923 728296.3852151949 3288544.6948651727 1.0 0.9398294809735812 4.243699840443855 19.563695230375036 -6.902752145184519 0.9436928361412324 0.8728162546015433 4.6105657900191925 0.9878868235219902 0.16987440208362162 0.10940812563110769 0.1662097473440972 0.13427585081495638 0.35444777814215245 1.2509727651995517e-07 6.902752145184519 3.7377495354176493 up TAK(ub)EVQTIEVYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAKEVQTIEVYK 12 1 Q86W42;Q86W42-2;Q86W42-3 Q86W42 THOC6 THO complex subunit 6 homolog 1 5321230.0 800330.0 0.0 4520900.0 True False 665509.8556306044 0.0 5466199.2877201615 1.0 0.0 8.213551221627904 19.344100505809312 -6.876456356744063 1.0994205145922868 0.4050728046406648 8.757379938168043 0.9707106472625968 0.6262144604303826 0.13081298224155288 0.2916764255398131 0.4400876789490906 1.0552577093754465 1.329057110435858e-07 6.876456356744063 8.352307133527379 up TAK(ub)GDLHYFINGQDQGAACSGLPPGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAKGDLHYFINGQDQGAACSGLPPGK 26 1 I3L2Z9;I3L100;Q96JN8 I3L2Z9 NEURL4 Neuralized-like protein 4 1 15031900.0 5055800.0 6450800.0 3525300.0 True False 6628202.760436849 5488365.785021452 3160535.7730654264 1.0 0.8280322710978334 0.4768314861956823 22.660186305408356 -6.959634185352143 0.44056318754313756 1.0124839670739216 0.27867426937879197 0.9997563785257606 0.003398259987232619 0.07983211623733982 0.021616500658462892 0.0046336302462298305 0.029096078460233005 1.0974021700359989e-07 6.959634185352143 -0.7338096976951296 down TAK(ub)GDLHYFINGQDQGAACSGLPPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAKGDLHYFINGQDQGAACSGLPPGK 26 1 I3L2Z9;I3L100;Q96JN8 I3L2Z9 NEURL4 Neuralized-like protein 4 1 13306100.0 5055800.0 3201300.0 5049000.0 True False 6925065.887857687 3059855.980716567 3856530.187419059 1.0 0.4418522553094658 0.5568943674862423 22.723396366931247 -10.409681193102609 8.758285931772559 1.00000338324226 0.4993733113980823 0.9619040574135109 0.046965745627520976 3.102711064182067e-06 2.0913164926244892e-07 0.045474694415287044 0.015158129221466875 3.8933084010671106e-11 10.409681193102609 -0.5006300718441776 TALEK(ub)YHDGIEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TALEKYHDGIEK 12 1 Q9BZD4;E9PQC4 Q9BZD4 NUF2 Kinetochore protein Nuf2 1 8861000.0 1103200.0 3134500.0 4623300.0 True False 1428114.1473230908 2960062.3195530535 3781906.8390640044 1.0 2.0727070907472642 2.6481824622723247 20.445679866054952 -9.170854679595756 0.19375988399530394 2.590561657454158e-22 3.27265026430344 0.9995805176135106 0.013988667054343562 0.6164347458389874 0.06891381898242165 0.7095436989847937 0.33266400929150597 6.747537710388721e-10 9.170854679595756 3.27265026430344 TALIHDGLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TALIHDGLAR 10 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 14746400.0 1984000.0 7266900.0 5495500.0 False True 2601043.2130833296 6182706.84615434 4926878.376558323 1.0 2.3770104299133243 1.8941932036253644 21.310658937379834 -9.923449505633423 6.594291960020805 0.9999999096499689 2.135601816769371 0.8806123528770722 0.19710930723865985 2.6193677632170124e-07 4.269529009487323e-08 0.19085028029849513 0.06361675535980338 1.1927529362866113e-10 9.923449505633423 1.1356019071194021 TALIHDGLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TALIHDGLAR 10 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 13057000.0 4050600.0 2081000.0 6925400.0 False True 3922015.92018634 2911954.152271634 5111429.9824533835 1.0 0.7424636236900546 1.3032659954655494 21.90316396103151 -6.78184497736558 1.528727524869562 0.8545257627292346 1.3079644973401952 0.7738485637683189 0.10899702653361622 0.24771895937266963 1.1435940840818857 0.05615060093099583 0.13228648097498924 1.6525515758852346e-07 6.78184497736558 0.4534387346109605 TALIHDGLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TALIHDGLAR 10 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 38989100.0 7467300.0 26713000.0 4808800.0 False True 11328440.032754783 21945856.440378375 3858338.5722280852 1.0 1.9372355220069706 0.3405886919180555 23.43344587471185 -6.747606375934968 1.65861930798594 1.5526770570266113 0.33796736998391863 0.6386630169103997 0.3937948484066915 0.30422791516752307 1.6458975479544322 0.18761204563197995 0.4566369143662772 1.788107497053871e-07 6.747606375934968 -1.2147096870426926 TALIHDGLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TALIHDGLAR 10 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 9905700.0 1984000.0 4041500.0 3880200.0 False True 2717538.4155840105 3862933.166546723 2963776.6752274595 1.0 1.4214824505862826 1.090610774159206 21.373868998902726 -9.958411623733054 5.337521534026415 0.9999992939773359 1.2560466123737952 0.44397126173635104 0.1350777962679493 1.1346979352899687e-06 2.216364443862897e-07 0.1307888763318206 0.04359617128181519 1.1004957666594557e-10 9.958411623733054 0.25604731839645933 TALIHDGLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TALIHDGLAR 10 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 8297200.0 4050600.0 2704100.0 1542500.0 False True 3368253.372005708 2689532.4765781783 1865029.6182858145 1.0 0.7984947031988365 0.5537082316272536 21.683569236465786 -6.96852485736203 0.29127715427645856 1.0471048634121696 0.2975217207562391 0.9999684780240797 0.0010245254862750245 0.07678436927748153 0.010734823660328147 0.0042474292952109985 0.02216573202119546 1.0751650602785548e-07 6.96852485736203 -0.7495831426559305 TALIHDGLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TALIHDGLAR 10 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 18499400.0 7467300.0 5258900.0 5773200.0 False True 9666567.052488858 4966237.592055373 4722536.838034363 1.0 0.5137540106109038 0.48854332798720396 23.2045721968043 -13.94850036824733 0.4221848640248829 9.99999958053225 0.48778010974489683 0.9998661641479726 0.0027231131643166927 28.957114248381114 0.21683888986040475 240.23729230218174 0.006085820267280983 1.1258995142209028e-14 13.94850036824733 -9.512219470787354 TALINSTGEEVAMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TALINSTGEEVAMR 14 0 P02545;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 35370000.0 4224100.0 12907700.0 18238200.0 False True 5537836.0062425835 10981921.473820515 16351086.01716787 1.0 1.9830709073798916 2.952612897661819 22.400890900659267 -6.971295875040715 0.22509371790690982 0.5806761982029343 4.382548818369599 0.9999908018262482 0.002417650782425826 0.0758844180647217 0.007507825060248828 0.025838114477648614 0.09723640831723199 1.0683268042706166e-07 6.971295875040715 3.801872620166664 TALINSTGEEVAMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 TALINSTGEEVAMR 14 0 P02545;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 26015100.0 7618500.0 4215000.0 14181600.0 False True 7376654.887656061 5898071.480934629 10467013.52111947 1.0 0.799559091588294 1.4189376730413064 22.814535310941945 -6.819579936151716 1.373654565955737 0.8919172822565448 1.4323420529284034 0.8834236494855255 0.08810724132071376 0.19402684850200294 0.7195032948019083 0.05040458168775954 0.11618971301219069 1.5150259226789059e-07 6.819579936151716 0.5404247706718587 TALINSTGEEVAMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TALINSTGEEVAMR 14 0 P02545;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 62799400.0 7933100.0 49829000.0 5037300.0 False True 12035092.687296197 40936625.63424598 4041675.447072974 1.0 3.4014383351992943 0.33582420610181246 23.520743916866294 -6.697760232398251 1.8389324939100535 2.494464113600452 0.3453459446887778 0.40692316900493586 1.014099062571849 0.40019961572708684 2.629521489440377 0.44021567057142574 1.1352273302574125 2.00557897245284e-07 6.697760232398251 -2.149118168911674 TALINSTGEEVAMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TALINSTGEEVAMR 14 0 P02545;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 29907000.0 4224100.0 12500200.0 13182700.0 False True 5785863.922010288 11947899.831366397 10069217.766228821 1.0 2.0650156990237547 1.740313616420189 22.464100962182158 -10.28804528358835 5.003859161087549 0.9997528245641365 1.9026646577223498 0.9115386388472183 0.13255907013427248 0.0003656260246512619 5.202142317186651e-05 0.12838385120977996 0.04278325591804396 5.151749248443734e-11 10.28804528358835 0.9029118331582133 TALINSTGEEVAMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TALINSTGEEVAMR 14 0 P02545;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 11800700.0 5284400.0 4148600.0 2367700.0 False True 4394212.738613286 4126250.6683673705 2862775.1229921044 1.0 0.9390193224166752 0.6514876027362142 22.067173286493837 -6.941122291634225 0.6490422934811256 1.0031753635796319 0.5713215873937201 0.9983071855926814 0.006252625997642524 0.0872584609890079 0.05230668094543013 0.006139499338810572 0.024627503168431 1.1451904254246308e-07 6.941122291634225 -0.4318537761859118 TALINSTGEEVAMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TALINSTGEEVAMR 14 0 P02545;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 40154700.0 11120300.0 15621200.0 13413200.0 False True 14395447.56388412 14751866.487861596 10972135.231054297 1.0 1.0247591415547006 0.7621947968176851 23.779109308142992 -6.8838016812385225 1.0583981171093775 1.0162745908049102 0.7421776464388166 0.9766236577475582 0.0180980615902935 0.12431457953030586 0.2524035274469637 0.01312405095972874 0.032066384006919815 1.3067674818187678e-07 6.8838016812385225 -0.27409694436609366 TALLDAAGVASLLTTAEVVVTEIPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TALLDAAGVASLLTTAEVVVTEIPK 25 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 84972100.0 18964000.0 56253000.0 9755100.0 False True 28769774.454108167 46214212.643304914 7827000.209187778 1.0 1.606346018354196 0.2720563632388896 24.77805057506228 -6.783141000846635 1.5235069261734253 1.3419250196629615 0.26040233504330146 0.7783934591227295 0.25678290076397436 0.24572109268320388 1.1266692197651569 0.1327220402698545 0.31237283404631017 1.6476273753524462e-07 6.783141000846635 -1.0815226846196602 TALNLFFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TALNLFFK 8 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 36609300.0 9207300.0 14016000.0 13386000.0 False True 12070859.463620046 11924867.433940077 12000945.127578868 1.0 0.9879054155074898 0.994208006790909 23.525025066050823 -10.109616954759458 4.702844539432228 1.0000005809840187 0.9910567111532226 0.7286061253067861 0.002573022117386147 1.5674561451272528e-08 2.9684716870971123e-09 0.0024914797846973887 0.0008304393174429897 7.769320641460188e-11 10.109616954759458 -0.008943869830796092 TALNLFFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TALNLFFK 8 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 15635300.0 4511900.0 4753200.0 6370200.0 False True 4368672.204189193 6651177.547610545 4701653.518096354 1.0 1.5224711850050499 1.0762202560283325 22.058763429024317 -9.950785693855142 4.355361870470403 0.9999923432204583 1.2993457198920286 0.37498668216562847 0.1821811792625066 12515525.232937705 8169851.50275704 852.801776303897 0.062365462832743544 1.1199904155113055e-10 9.950785693855142 0.29935337667157036 TALNLFFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TALNLFFK 8 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 18512200.0 4254900.0 6990600.0 7266700.0 False True 6454994.374856812 5743072.812192905 5830433.559892245 1.0 0.8897099638944768 0.903243786331197 22.621984407634375 -9.880366818839425 4.9013225587487295 1.0000003366238337 0.8964768751167866 0.98734400087336 0.005525159898917435 7524708.844637022 1.2345839076400131 28.603876095171653 0.0018914091901521782 1.3171437673608106e-10 9.880366818839425 -0.10352346150704705 TALNLFFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TALNLFFK 8 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 26758700.0 9207300.0 6367400.0 11184000.0 False True 12611487.62792676 6086067.2138239695 8542569.541710198 1.0 0.4825812301751809 0.6773641455900581 23.588235127573714 -10.113231375751601 5.190528066794951 1.0000104828675422 0.5799726878820919 0.8611112166925199 0.07951979223153344 9.646665501382044e-06 1.6481510081922164e-06 0.07699662713529273 0.025664902583618462 7.704928701011514e-11 10.113231375751601 -0.42003779498545035 TALNLFFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TALNLFFK 8 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 14312500.0 4511900.0 3977600.0 5823000.0 False True 3751844.761060721 3956171.879308221 7040562.377489987 1.0 1.054460440466021 1.8765601526379467 21.839168704458594 -6.920347858660181 0.8221433812308366 0.9820875661260208 2.0101974760160957 0.9942770189006835 0.030335412542917422 0.09796743098352875 0.10455694923852149 0.026185340953897265 0.07870020016364271 1.201301837424509e-07 6.920347858660181 1.028109909890075 TALNLFFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TALNLFFK 8 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 15817400.0 4254900.0 7064300.0 4498200.0 False True 5508051.9266180275 6671165.494981224 3679573.7554296036 1.0 1.2111660499681154 0.6680354151433865 22.393110729726825 -6.801255284709558 1.4506571491210536 1.1163232691975056 0.6602919029978701 0.8358558406662691 0.09057174296946077 0.21896117755698796 0.9095454575386176 0.04911326716740072 0.11413952691985199 1.5803188314508814e-07 6.801255284709558 -0.45603136619963547 TALTTTISSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TALTTTISSR 10 0 Q9BV20;Q9BV20-2 Q9BV20 MRI1 Methylthioribose-1-phosphate isomerase 0 9953500.0 3438400.0 1572600.0 4942500.0 False True 4507775.697512964 1337974.2099467868 4431097.511807752 1.0 0.2968147263150151 0.9829897956662935 22.10398429953338 -10.813324826578993 10.668487194300774 1.003671797186191 0.6399022610789074 0.2685812745605499 0.2801297990215821 0.024514967932871633 0.000428957432238398 0.27178986680249745 0.09041150386558483 1.5370046217580013e-11 10.813324826578993 -0.3637695361072837 TALTTTISSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TALTTTISSR 10 0 Q9BV20;Q9BV20-2 Q9BV20 MRI1 Methylthioribose-1-phosphate isomerase 0 12093000.0 3137000.0 4603800.0 4352200.0 False True 4759058.345419593 3782215.9203464203 3491985.7623629756 1.0 0.794740397328109 0.7337556106501352 22.182244711179486 -13.999999999990049 0.1701011580810597 2.035404300097007 0.6800179427750074 0.9995134831323499 0.0025120616860324903 12.092498675447196 0.13060641419575628 4.131396896074954 0.049674329725716414 1.0000000000229134e-14 13.999999999990049 -1.3553863573219997 TALVANTSNMPVAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TALVANTSNMPVAAR 15 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 15848700.0 2726600.0 8071500.0 5050600.0 False True 3574599.0044319574 6867263.662460573 4528012.360776173 1.0 1.9211283990025774 1.266718967683404 21.769349979952306 -10.242578465960008 5.742928630790565 0.9999734592769872 1.5939236833429997 0.5234122021103594 0.2671615315995133 9.079088589645402e-05 1.1974448617992177e-05 0.25868956873961924 0.08622601355267707 5.720335934032624e-11 10.242578465960008 0.5939502240660125 TALVANTSNMPVAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TALVANTSNMPVAAR 15 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 15200800.0 2726600.0 6863000.0 5611200.0 False True 3734697.703594435 6559769.967093936 4285950.1262915125 1.0 1.7564393393287305 1.1476029565034216 21.832560041475197 -10.098235117193003 4.450298442662635 0.9999625902863035 1.452021147392553 0.42361296996719155 0.2485564125732894 86493255.10709485 3.0979752556305 38870.28075430497 0.08508747121979186 7.97562787944688e-11 10.098235117193003 0.45205855710624954 TAMAAAK(ub)APTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAMAAAKAPTK 11 1 P83731 P83731 RPL24 60S ribosomal protein L24 1 46132500.0 7904700.0 14757800.0 23470000.0 True False 10363138.249223698 12555993.765453856 21041549.54013721 1.0 1.2116014920860894 2.0304225451892846 23.304957621964796 -6.945637385429558 0.6048579917327465 0.9908668568990047 2.2934232277271556 0.9988128192044703 0.015310258993797645 0.0852865143810096 0.04358908179010874 0.01563925834329423 0.06892251962542402 1.133346256775367e-07 6.945637385429558 1.302556370828151 up TAMAAAK(ub)APTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAMAAAKAPTK 11 1 P83731 P83731 RPL24 60S ribosomal protein L24 1 65636600.0 12984600.0 25127000.0 27525000.0 True False 12572410.980410708 35160342.13557395 20315376.767699935 1.0 2.796626851473269 1.6158696052295518 23.583758002589484 -10.46314224394984 4.93723368678984 0.997303226386925 2.206248228351509 0.5818566873330935 0.4820421272321568 0.014327553013407943 0.0015579258913234833 0.4673344328144334 0.1555784275783298 3.4423716471233546e-11 10.46314224394984 1.2089450019645838 TAMAAAK(ub)APTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAMAAAKAPTK 11 1 P83731 P83731 RPL24 60S ribosomal protein L24 1 18561300.0 2355500.0 7995000.0 8210800.0 True False 3573465.710116629 6568229.784779886 6587931.781078522 1.0 1.838055914790215 1.843569328908856 21.768892514003806 TAMAAAK(ub)APTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAMAAAKAPTK 11 1 P83731 P83731 RPL24 60S ribosomal protein L24 1 38551000.0 7904700.0 11368000.0 19278300.0 True False 10827281.206485357 10865724.17105113 14725162.589051466 1.0 1.0035505648955294 1.360005555247918 23.368167683487687 -6.909081376160377 0.9019848448857756 0.9886392816346051 1.4051746942948544 0.9905693123224791 0.01639999363638336 0.10502976584214149 0.1420941488490031 0.013366026507700971 0.03666483128067759 1.232873801198091e-07 6.909081376160377 0.4165354126602493 TAMAAAK(ub)APTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAMAAAKAPTK 11 1 P83731 P83731 RPL24 60S ribosomal protein L24 1 49815800.0 12984600.0 30969000.0 5862200.0 True False 10797270.215312637 30802163.850134805 7087958.916249659 1.0 2.8527732691593957 0.6564584172578685 23.36416327802376 -6.683033406810655 1.8907647197743052 2.169036166307322 0.6645382222652146 0.3382120334341915 0.7847293883939062 0.43182112016551666 2.9871587899619936 0.3326837845358731 0.8741467611392828 2.0747539170455386e-07 6.683033406810655 -1.5044979440421073 TAMAAAK(ub)APTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAMAAAKAPTK 11 1 P83731 P83731 RPL24 60S ribosomal protein L24 1 10454080.0 2355500.0 7047200.0 1051380.0 True False 3049241.1838465733 6655017.1250133375 860039.6280698006 1.0 2.1825158207453206 0.28205037785331005 21.540018836096255 -6.73838537730748 1.6924278118380391 1.7048518338056464 0.2812474630233165 0.5979012320248058 0.4968593102249478 0.32066403199478183 1.802781157572395 0.23230359518117577 0.5711052911101245 1.8264787452671113e-07 6.73838537730748 -1.4236043707823298 TAMLLALQRPELVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAMLLALQRPELVER 15 1 Q8NFV4;Q8NFV4-4 Q8NFV4 ABHD11 Alpha/beta hydrolase domain-containing protein 11 0 5834600.0 1897700.0 2368300.0 1568600.0 False True 2487903.077352939 2014958.8715610972 1406296.3190736752 1.0 0.8099024796837979 0.5652536595476766 21.24649885200091 -6.967677516713585 0.30866144178860205 1.0382909315190092 0.32910356384205186 0.9999581802205679 0.001150753706998954 0.07706372989055839 0.011713775219495836 0.0038944769827513725 0.021748510706804395 1.0772648345564393e-07 6.967677516713585 -0.7091873676769573 TAMLLALQRPELVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAMLLALQRPELVER 15 1 Q8NFV4;Q8NFV4-4 Q8NFV4 ABHD11 Alpha/beta hydrolase domain-containing protein 11 0 7697100.0 1897700.0 3050500.0 2748900.0 False True 2599330.9734142 2915718.823345481 2099666.435372599 1.0 1.121718955057004 0.8077718677797712 21.309708913523803 -6.80156364225733 1.4494017055155604 1.0670251715778034 0.8032628715177141 0.8367296126737498 0.05222220264974186 0.21853145298573554 0.9061556568039842 0.028341955400322475 0.06585466568127495 1.5791971725226688e-07 6.80156364225733 -0.26376230006008927 TAMLLALQRPELVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAMLLALQRPELVER 15 1 Q8NFV4;Q8NFV4-4 Q8NFV4 ABHD11 Alpha/beta hydrolase domain-containing protein 11 0 4917400.0 2218500.0 1543000.0 1155900.0 False True 1844781.0462140564 1534687.5527384812 1397593.3457222534 1.0 0.8319076976034835 0.7575930751188376 20.81501816485849 -13.99999999929748 0.1106928567455903 1.8101021216141004 0.622615473392183 0.9997395419912378 0.0016364654425790293 12.008631241802219 0.10107255289395459 2.1713975842770434 0.11986842763279842 1.0000000016176137e-14 13.99999999929748 -1.1874866482219173 TAMSTPHVAEPAENEQDEQDENGAEASADLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAMSTPHVAEPAENEQDEQDENGAEASADLR 31 0 P26038 P26038 MSN Moesin 0 17197600.0 2714600.0 9694500.0 4788500.0 False True 3558866.888223791 8248118.388865034 4293031.954535449 1.0 2.317624864295394 1.2062918028041434 21.762986542269992 -6.604436976045537 2.174221459859964 1.8835392741364947 1.2100519194476134 0.03359873317694373 0.5688677340386222 0.6280248880572983 5.61734826292095 0.21667881915134096 0.6322095519749039 2.486354352864982e-07 6.604436976045537 -0.6734873546888813 TAMSTPHVAEPAENEQDEQDENGAEASADLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAMSTPHVAEPAENEQDEQDENGAEASADLR 31 0 P26038 P26038 MSN Moesin 0 11718400.0 2313400.0 1740600.0 7664400.0 False True 2239962.383291137 2435630.6571090855 5656863.712928596 1.0 1.0873533748948305 2.5254279960795887 21.09504307397535 -6.919331175099738 0.8296870221223457 0.9674985408568443 2.753788905493266 0.9939928217583871 0.054208774983596254 0.09856670162236833 0.10767005471890863 0.046541761348726465 0.13853259584493136 1.204117379826264e-07 6.919331175099738 1.7862903646364217 up TAMSTPHVAEPAENEQDEQDENGAEASADLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAMSTPHVAEPAENEQDEQDENGAEASADLR 31 0 P26038 P26038 MSN Moesin 0 14811200.0 2714600.0 5380900.0 6715700.0 False True 3718260.9793066275 5143154.045743218 5129589.974183043 1.0 1.3832149153506434 1.3795669542108357 21.826196603792884 -10.04087157150826 4.562217861072926 0.9999839849946742 1.3813909348036086 0.9999313883741768 0.0014892739752913147 779056.162641205 0.006999708422073569 131.3948788525706 0.000545018455740637 9.101823897276506e-11 10.04087157150826 0.3814069498089344 TANDMIHAENMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TANDMIHAENMR 12 0 P26038 P26038 MSN Moesin 0 13933830.0 2925930.0 5914200.0 5093700.0 False True 3835922.5647464218 5031824.413371045 4566652.786220572 1.0 1.3117638139037042 1.1904966039173568 21.87114216648316 -10.116945256215443 4.324104357882749 0.9999632624448274 1.2511302089010115 0.8511478438139557 0.049507131244893095 34519058.99405327 1.0170308989887367 13111.304969666871 0.01694760782592392 7.639320728442592e-11 10.116945256215443 0.2511669464561841 TANDMIHAENMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 TANDMIHAENMR 12 0 P26038 P26038 MSN Moesin 0 14885450.0 4909460.0 3246690.0 6729300.0 False True 4753611.879602536 4543110.248264676 4966694.455327275 1.0 0.9557175392797402 1.044825404581107 22.180592685008627 -6.771563513841802 1.5683143598364433 0.9746520133511491 1.0453584629834622 0.7365791144541933 0.018671026233386047 0.2638984913798448 1.2811850137917862 0.009382447155213013 0.022303651219408624 1.6921407574797816e-07 6.771563513841802 0.0707064496323131 TANDMIHAENMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TANDMIHAENMR 12 0 P26038 P26038 MSN Moesin 0 32978500.0 4484000.0 26215000.0 2279500.0 False True 6802555.824310314 21536728.431270134 1828955.8258596568 1.0 3.165975993067821 0.2688630381133385 22.69764546014131 -6.706575199514289 1.8073748142341166 2.3362114138850067 0.2763110280578249 0.4488742132548442 0.9132320262812486 0.3819823533996003 2.430137696433109 0.4024252624022483 1.026632330038994 1.9652816561510052e-07 6.706575199514289 -2.0599003858271816 TANDMIHAENMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TANDMIHAENMR 12 0 P26038 P26038 MSN Moesin 0 12095800.0 2456000.0 5080700.0 4559100.0 False True 3364049.570904403 4856217.874371865 3482334.4776118505 1.0 1.4435631140436203 1.0351614636509792 21.68176753388603 -10.525845432180448 6.947252433571896 0.9998783858309089 1.239362288847299 0.3141337754022998 0.16672927559541598 0.00031421730999545 2.1445601863443082e-05 0.16151633610703964 0.053811642308856045 2.979576688643387e-11 10.525845432180448 0.2394839030163901 TANDMIHAENMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TANDMIHAENMR 12 0 P26038 P26038 MSN Moesin 0 2349460.0 929960.0 1077400.0 342100.0 False True 773302.9442133083 1071595.8323528448 413631.52830831625 1.0 1.3857387203445786 0.5348893747315411 19.560674180299575 -6.783487990343125 1.5226405615401435 1.217429263090644 0.5274407679258933 0.7794131696072514 0.16337883963697689 0.24519771916874672 1.123082071987543 0.08449943037933821 0.19877973120117753 1.6463114915734357e-07 6.783487990343125 -0.6899884951647507 TANDMIHAENMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TANDMIHAENMR 12 0 P26038 P26038 MSN Moesin 0 13209200.0 4484000.0 5901600.0 2823600.0 False True 5804626.392854178 5573170.77207667 2309733.772582598 1.0 0.9601256644075417 0.3979125642652919 22.46877178223376 -6.921199657881396 0.8157841932793869 1.0118767828128659 0.30470217480602574 0.9945075936963507 0.0203738396281558 0.09747119366322242 0.10199578641861261 0.017666537871376148 0.05354175212150847 1.1989479849589526e-07 6.921199657881396 -0.7071746080068402 down TANKDHLVTAYNHLFETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TANKDHLVTAYNHLFETK 18 1 Q00688 Q00688 FKBP3 Peptidyl-prolyl cis-trans isomerase FKBP3 0 7677700.0 2477300.0 2346100.0 2854300.0 False True 3247764.290207328 1996071.0250261747 2558964.416378933 1.0 0.6145984888881056 0.7879156822109082 21.631015500588433 -10.014215167985515 4.642765637311263 1.0000075070838146 0.7012570855323288 0.798444716722422 0.07075644793671172 22575968.597941462 24347621.15409445 1473.0837805573349 0.02422181418142004 9.677982489853019e-11 10.014215167985515 -0.2987504215514858 TANKDHLVTAYNHLFETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TANKDHLVTAYNHLFETK 18 1 Q00688 Q00688 FKBP3 Peptidyl-prolyl cis-trans isomerase FKBP3 0 11212600.0 2477300.0 2735800.0 5999500.0 False True 3393224.75651526 2614923.3099192157 4582541.663581035 1.0 0.7706307414203425 1.350497533292539 21.694225562111324 -6.799394784181891 1.4583715552346908 0.8733448572441923 1.358382684711396 0.8303642202088919 0.09820802936365464 0.2216392661657428 0.9307062413050432 0.05297779702640617 0.12325312722653942 1.587103377333752e-07 6.799394784181891 0.4850378274672037 TANPSK(ub)TIDLGAAAHYTGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TANPSKTIDLGAAAHYTGDK 20 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 7107300.0 2970000.0 2164500.0 1972800.0 True False 2469686.5933088786 2152839.4088803884 2385303.3588034096 1.0 0.8717055089957875 0.965832411799097 21.235896542726394 -10.295530384798187 4.66735459329755 1.0000418515209488 0.9187689603972623 0.4982472864410529 0.038427147156750226 1.6743518448624372e-05 2.527146581647016e-06 0.0372260875817217 0.012402308414938966 5.0637192069041696e-11 10.295530384798187 -0.08127289112368652 TAPAANLASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAPAANLASR 10 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 4634240.0 1464700.0 953740.0 2215800.0 False True 1418203.9002362445 1334573.3556883961 1635415.5074248705 1.0 0.9410306624217313 1.1531596459101845 20.435633538228835 -6.832554002413452 1.3166309884457537 0.9685433160186631 1.1591644104370784 0.9108548304991557 0.026692831493313213 0.17768230602391333 0.6015158981257824 0.01591436040356743 0.0366199306413395 1.4704355625025412e-07 6.832554002413452 0.19062109441841535 TAPLLLSYYLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAPLLLSYYLIK 12 0 Q12769;G3V198;E9PR16 Q12769 NUP160 Nuclear pore complex protein Nup160 0 6068600.0 1558400.0 2492800.0 2017400.0 False True 2043077.4915670652 2120883.956858295 1808658.8002672659 1.0 1.0380829731678711 0.8852619676603665 20.962312494187938 -6.840721690519876 1.2789380683005571 1.0202587243988788 0.8801603302555296 0.9256979017787312 0.017705005463098382 0.16796281720660197 0.5333451794886985 0.010853406939670546 0.025010601752550026 1.4430398002990995e-07 6.840721690519876 -0.14009839414334913 TAPLLLSYYLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAPLLLSYYLIK 12 0 Q12769;G3V198;E9PR16 Q12769 NUP160 Nuclear pore complex protein Nup160 0 7850600.0 1558400.0 2720000.0 3572200.0 False True 2134582.594176471 2599821.4061628305 2728519.9317683433 1.0 1.2179530617628083 1.2782451891120266 21.02552255571083 -13.652877771234692 0.18425235099368295 4.169047458375851e-09 1.3247660651456 0.9994839095028138 0.002715138852691879 10.714326267119876 0.13387893768923684 3.8624991516280844 0.043446605731075665 2.2239357117912858e-14 13.652877771234692 1.3247660609765524 TAPVQAPPAPVIVTETPEPAMTSGVYRPPGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAPVQAPPAPVIVTETPEPAMTSGVYRPPGAR 32 1 Q9UKY7;Q9UKY7-2;H0Y8K3;D6R9V8;D6RFH2;Q9UKY7-3;D6RAV0 Q9UKY7 CDV3 Protein CDV3 homolog 0 34596000.0 4505000.0 17943000.0 12148000.0 False True 5906098.626482053 15265974.341266194 10891041.491844343 1.0 2.5847814787270695 1.8440331224762418 22.49377401769386 -10.670775964607387 7.099856728137389 0.9944163152998429 2.2144073006016556 0.7818334495714503 0.302409250103317 0.02662862346891872 0.0012347813539822232 0.29171717376312706 0.09760216578243508 2.1341455507433786e-11 10.670775964607387 1.2199909853018127 TAPVQAPPAPVIVTETPEPAMTSGVYRPPGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAPVQAPPAPVIVTETPEPAMTSGVYRPPGAR 32 1 Q9UKY7;Q9UKY7-2;H0Y8K3;D6R9V8;D6RFH2;Q9UKY7-3;D6RAV0 Q9UKY7 CDV3 Protein CDV3 homolog 0 34183000.0 9693100.0 7141900.0 17348000.0 False True 9385397.84623468 9993697.914516479 12804038.371155625 1.0 1.0648134557796975 1.3642509972331613 23.161986471399434 -6.941583071134647 0.6446706212898425 0.996709222047042 1.4489038859168077 0.9983639548972663 0.006417279692916578 0.08705184402680369 0.05137666902833381 0.006324373133151497 0.025597604151848165 1.1439760410313205e-07 6.941583071134647 0.4521946638697657 TAPVQAPPAPVIVTETPEPAMTSGVYRPPGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAPVQAPPAPVIVTETPEPAMTSGVYRPPGAR 32 1 Q9UKY7;Q9UKY7-2;H0Y8K3;D6R9V8;D6RFH2;Q9UKY7-3;D6RAV0 Q9UKY7 CDV3 Protein CDV3 homolog 0 94243000.0 6801400.0 79772000.0 7669600.0 False True 10318221.048943836 65536063.33851919 6153700.198294898 1.0 6.351488597467817 0.5963915842765148 23.29869092323859 -6.662548564828578 1.9641728135175571 4.437563631700091 0.6204502251616854 0.24631142618452384 2.2771878198588253 0.4784619479949985 3.551194811081942 0.9358740167974716 2.524617952291423 2.1749608061887152e-07 6.662548564828578 -3.817113406538406 TAPVQAPPAPVIVTETPEPAMTSGVYRPPGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAPVQAPPAPVIVTETPEPAMTSGVYRPPGAR 32 1 Q9UKY7;Q9UKY7-2;H0Y8K3;D6R9V8;D6RFH2;Q9UKY7-3;D6RAV0 Q9UKY7 CDV3 Protein CDV3 homolog 0 39306000.0 4505000.0 18202000.0 16599000.0 False True 6170620.2430473585 17397775.45403524 12678658.067135861 1.0 2.8194532751610972 2.0546813071864736 22.55698407921675 -10.579908928016813 6.0910208352050415 0.9960309366091545 2.4370672911730193 0.8248048157675316 0.3122168485203259 0.01682246973746238 0.0011602269071820425 0.3021968218610734 0.1007675545603819 2.6308196195359597e-11 10.579908928016813 1.441036354563865 TAPVQAPPAPVIVTETPEPAMTSGVYRPPGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAPVQAPPAPVIVTETPEPAMTSGVYRPPGAR 32 1 Q9UKY7;Q9UKY7-2;H0Y8K3;D6R9V8;D6RFH2;Q9UKY7-3;D6RAV0 Q9UKY7 CDV3 Protein CDV3 homolog 0 17230800.0 9693100.0 4419800.0 3117900.0 False True 8060242.127138822 4395989.660138386 3769838.4744592216 1.0 0.5453917625299488 0.4677078448755505 22.94239174683371 -13.999999999999998 0.2485668955499125 4.138896366721806 0.43604378113212494 0.9995400160627406 0.005035092261792157 13.941632342803356 0.15776569313027383 21.831727724460098 0.03613861333212183 1.0000000000000041e-14 13.999999999999998 -3.702852585589681 TAPYVVTGSVDQTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAPYVVTGSVDQTVK 15 0 P43034;I3L3N5 P43034 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit alpha 0 13871600.0 3167700.0 3459600.0 7244300.0 False True 3067143.0974113173 4841036.321575669 5346800.505658451 1.0 1.5783535908909907 1.7432510762771958 21.54846404636593 -11.33878314092195 0.22833335918920203 1.1779550067034795e-10 1.8383801182232793 0.9993076225313662 0.008385876024598055 3.6678788876859785 0.1287715923909729 1.930868711423357 0.08576829661620716 4.583707107971192e-12 11.33878314092195 1.8383801181054837 TAQALSSGSGSQETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAQALSSGSGSQETK 15 0 O95747;C9JIG9 O95747 OXSR1 Serine/threonine-protein kinase OSR1 0 2976350.0 738120.0 690030.0 1548200.0 False True 714688.7846264604 965562.5774589129 1142679.9749955703 1.0 1.3510252269644532 1.5988497365224557 19.446955623154032 -6.974870098883172 0.08008434120052352 0.13131596423591116 2.8247781914667116 0.9999998985471197 7.804198117616582e-05 0.07475174783052824 0.00232317488453419 0.029779087443751247 0.04803543520686044 1.0595706042261472e-07 6.974870098883172 2.6934622272308006 TAQALSSGSGSQETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAQALSSGSGSQETK 15 0 O95747;C9JIG9 O95747 OXSR1 Serine/threonine-protein kinase OSR1 0 4996380.0 800230.0 3431500.0 764650.0 False True 1214007.4146493864 2819122.014568129 613516.5923419992 1.0 2.3221621058898645 0.5053647819104852 20.21134580232241 -6.711579946730295 1.789708295137292 1.8115444451493936 0.5094679131010428 0.4724813054997793 0.5570194078184187 0.3719416157156302 2.323326422935742 0.24759392578920086 0.6277709398875055 1.9427640268458218e-07 6.711579946730295 -1.3020765320483507 TAQEVETYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAQEVETYR 9 0 J3KTA4;P17844;P17844-2;J3QRQ7;J3QR02;J3KRX8;J3KTQ4 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 9221400.0 2564300.0 1860800.0 4796300.0 False True 2482897.700126853 2603827.1439438076 3540005.1440842585 1.0 1.0487049642886117 1.4257555371304251 21.243593390420052 -6.930711496897871 0.740921136708557 0.9944152023280943 1.5045855324732524 0.9966764309032426 0.010968855210278905 0.09226968265517956 0.07588034871429282 0.010035856038107048 0.033983953219061544 1.1729743170796013e-07 6.930711496897871 0.5101703301451581 TAQEVETYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAQEVETYR 9 0 J3KTA4;P17844;P17844-2;J3QRQ7;J3QR02;J3KRX8;J3KTQ4 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 8983900.0 1477300.0 3814100.0 3692500.0 False True 2023497.732531379 3645580.450457959 2820407.549424616 1.0 1.80162319524686 1.393827877383539 20.948419801693227 -10.388711003763472 5.547572820545836 0.9997571543364521 1.5977255363151914 0.7412383136862015 0.16648174137688207 0.0005002363018840453 5.5120772978795684e-05 0.16125917442950471 0.05373175098335421 4.085911881661667e-11 10.388711003763472 0.5979683819787394 TAQGSLSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAQGSLSLK 9 0 A0A087WZK9;B3KS98;O15372;E5RJT0;E5RGU4 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 0 11442300.0 4173300.0 3010400.0 4258600.0 False True 5471236.714294688 2561260.0544472914 3817960.92337572 1.0 0.4681318298211249 0.6978241159627662 22.383435544922435 -10.31110198948183 5.754005936364923 1.000045314349812 0.5829779728919448 0.8146449352431447 0.09377148315007007 5.4516239839877916e-05 6.526951578417289e-06 0.09080368122555806 0.03026461604911464 4.8853761795982046e-11 10.31110198948183 -0.4170673414578673 TAQGSLSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAQGSLSLK 9 0 A0A087WZK9;B3KS98;O15372;E5RJT0;E5RGU4 A0A087WZK9 EIF3H Eukaryotic translation initiation factor 3 subunit H 0 11664100.0 4843000.0 3620700.0 3200400.0 False True 6269358.969802143 3419204.862148906 2617960.038877089 1.0 0.5453834879480213 0.41758017868925923 22.579886507029958 -13.999999999999996 0.17800748881952452 3.344644777642379 0.3139433560518772 0.9995006765048006 0.005585006787632727 12.179609431332603 0.13372848265059473 9.872626599386033 0.09706331091572153 1.0000000000000082e-14 13.999999999999996 -3.0307014215905017 TAQNFLSIFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAQNFLSIFLK 11 0 A0A590UJS4;Q6KC79-2;Q6KC79 A0A590UJS4 NIPBL Nipped-B-like protein 0 8342900.0 3485100.0 3196300.0 1661500.0 False True 4511530.651591463 3018423.0952264867 1359124.0484296572 1.0 0.6690463455372345 0.3012556388041429 22.1051855568654 -7.271685331967243 0.3106817080584486 1.0689237848272468 8.879683196295676e-15 0.9998611225552404 0.003363248738983598 0.10019873630236109 0.020477063505286712 0.011967998386239848 0.04667366645203444 5.349518183113052e-08 7.271685331967243 -1.068923784827238 down TAQNLSIFLGSFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAQNLSIFLGSFR 13 0 H9KV28;A0A140T8Z0;A0A0G2JH68;O60610-2;O60610-3;O60610;A0A2R8Y5N1 H9KV28 DIAPH1 Protein diaphanous homolog 1 0 23338800.0 7352600.0 8241700.0 7744500.0 False True 9639329.802679677 7012070.485894977 6943173.430489658 1.0 0.7274437776727655 0.7202962833120926 23.200501412463815 TAQNLSIFLGSFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAQNLSIFLGSFR 13 0 H9KV28;A0A140T8Z0;A0A0G2JH68;O60610-2;O60610-3;O60610;A0A2R8Y5N1 H9KV28 DIAPH1 Protein diaphanous homolog 1 0 29305800.0 11675000.0 8502000.0 9128800.0 False True 11304383.515571898 11896892.937344292 6737693.421870273 1.0 1.0524141295238443 0.5960248440429357 23.430378981088378 -6.878315537115565 1.0890958065187313 1.0318191606523166 0.5647007618441812 0.9723035515830848 0.03393615248578851 0.12913525230978623 0.2813609709010657 0.024037537741647526 0.0578907779314219 1.3233796829100483e-07 6.878315537115565 -0.46711839880813544 TAQNLSIFLGSFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAQNLSIFLGSFR 13 0 H9KV28;A0A140T8Z0;A0A0G2JH68;O60610-2;O60610-3;O60610;A0A2R8Y5N1 H9KV28 DIAPH1 Protein diaphanous homolog 1 0 66943000.0 16057000.0 24758000.0 26128000.0 False True 24359642.923940826 20339741.464863084 20963789.347690783 1.0 0.8349769956961498 0.8605951003939973 24.5379896498517 -10.40056555704332 8.60835261962938 1.0000010527164316 0.8477860480588284 0.9791974423097156 0.010458547447820514 2.113035777212241e-07 1.4715796847050894e-08 0.010126515109833941 0.0033754816742440816 3.975890756069626e-11 10.40056555704332 -0.15221500465760318 TAQNLSIFLGSFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAQNLSIFLGSFR 13 0 H9KV28;A0A140T8Z0;A0A0G2JH68;O60610-2;O60610-3;O60610;A0A2R8Y5N1 H9KV28 DIAPH1 Protein diaphanous homolog 1 0 33658800.0 7352600.0 9076200.0 17230000.0 False True 10071054.916543841 8675183.473020252 13160628.862988811 1.0 0.8613976931820146 1.30677758904578 23.263711473986707 -6.823094631401581 1.358284808203276 0.9255143846271257 1.3171718907869054 0.8913629828769564 0.06133756689536258 0.18950598085045256 0.6861133415412983 0.03547670967488057 0.08171447213275598 1.502814471864856e-07 6.823094631401581 0.3916575061597798 TAQNLSIFLGSFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAQNLSIFLGSFR 13 0 H9KV28;A0A140T8Z0;A0A0G2JH68;O60610-2;O60610-3;O60610;A0A2R8Y5N1 H9KV28 DIAPH1 Protein diaphanous homolog 1 0 25848400.0 11675000.0 6765500.0 7407900.0 False True 9708279.790195689 6729052.908653389 8956857.639740352 1.0 0.6931251523518104 0.9225998666402062 23.210784256522654 -10.00991231069374 6.409658046918578 1.0000000865940497 0.8078625105520899 0.48313609916868205 0.0936826598129313 1.1592454163263852e-07 1.792459786803311e-08 0.09070788654622718 0.030235948440323304 9.774345568865251e-11 10.00991231069374 -0.1921375760419598 TAQNLSIFLGSFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAQNLSIFLGSFR 13 0 H9KV28;A0A140T8Z0;A0A0G2JH68;O60610-2;O60610-3;O60610;A0A2R8Y5N1 H9KV28 DIAPH1 Protein diaphanous homolog 1 0 56907000.0 16057000.0 20895000.0 19955000.0 False True 20786103.03078936 19732174.88181883 16323394.75559062 1.0 0.949296501253294 0.7853032736060066 24.30911597194415 -6.949748837187785 0.5615980634092743 1.002127142004763 0.7246136584506088 0.9991813946490282 0.0026215549657435644 0.0835868352201748 0.03638153326426111 0.0028047640620395328 0.013637053951190792 1.122667531889418e-07 6.949748837187785 -0.2775134835541543 TAQQNGDTPEAQGLDITTYGESNLVAEPQK(ub)VNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAQQNGDTPEAQGLDITTYGESNLVAEPQKVNK 33 1 E9PHA2;Q15003;Q15003-2 E9PHA2 NCAPH Condensin complex subunit 2 1 19578200.0 6146400.0 4213200.0 9218600.0 True False 7956635.963657214 3978731.7162995473 7540909.390823742 1.0 0.500051998667883 0.9477509622493291 22.923727162859596 -10.355846730226054 8.50764056657362 1.000000913775667 0.7239014804586063 0.3364745902340335 0.18277233652456865 3.1676441246105697e-06 2.3991140854448814e-07 0.17696913660640728 0.05898951795892269 4.407103701125201e-11 10.355846730226054 -0.27609943331706066 TASAEEIK(ub)AFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TASAEEIKAFEK 12 1 Q9Y263;E5RIM3 Q9Y263 PLAA Phospholipase A-2-activating protein 1 4723000.0 933380.0 682020.0 3107600.0 True False 903750.3628063801 954354.1426873147 2293626.33399834 1.0 1.0559930949557759 2.5378981059283157 19.7855647956639 -6.914884172681093 0.8618031648392377 0.9608964502658057 2.75085614902275 0.9926380433984879 0.061103045132227654 0.10127633253499137 0.12190054865925594 0.05126688677074228 0.1468015774020294 1.216510403456296e-07 6.914884172681093 1.7899596987569442 up TASAEEIK(ub)AFEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TASAEEIKAFEK 12 1 Q9Y263;E5RIM3 Q9Y263 PLAA Phospholipase A-2-activating protein 1 5040080.0 933380.0 2087800.0 2018900.0 True False 776146.8257449972 2076552.6070041452 2441042.6556610935 1.0 2.6754636341016176 3.145078449967271 19.565970071098175 -9.896549511273529 0.32175365641821935 1.7270626461312238e-24 3.281129096125059 0.9987924021132487 0.031994545014861576 1.2725183495189645 0.14129603270835173 1.3733421800533876 0.15298452828868847 1.268967468932289e-10 9.896549511273529 3.281129096125059 TASAEEIK(ub)AFEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TASAEEIKAFEK 12 1 Q9Y263;E5RIM3 Q9Y263 PLAA Phospholipase A-2-activating protein 1 20744600.0 1772200.0 7675800.0 11296600.0 True False 2294147.835284605 7248634.982429526 9240734.712904297 1.0 3.1596198252543224 4.0279595633635 21.129526931192245 -9.26508397793553 0.301460416263521 1.3363104006786579e-14 4.387351048282883 0.998650426560423 0.04676842151932187 0.6702763561526814 0.11384222050732445 1.017826136849873 0.29932901486324925 5.431452953183321e-10 9.26508397793553 4.38735104828287 TASALFAGFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TASALFAGFR 10 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 11125900.0 2929900.0 3123000.0 5073000.0 False True 3841127.2731919647 2657060.5733586536 4548094.623652144 1.0 0.6917397900097814 1.1840520503952716 21.873098336723704 -6.737427961637528 1.6962369474099421 0.816041462393586 1.1841750670863294 0.5932971145339648 0.1295277475200336 0.3224848686647183 1.820861684771467 0.06043647012925699 0.14871935963309543 1.8305097159396535e-07 6.737427961637528 0.36813360469274337 TASALFAGFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TASALFAGFR 10 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 6230560.0 1812200.0 957260.0 3461100.0 False True 1754672.702948127 1339498.910044952 2554534.079225661 1.0 0.7633896098083606 1.4558464806192293 20.742770520726143 -6.814490234914614 1.3956430626321608 0.871717409438366 1.4692378409899967 0.8712157288798439 0.10313011604982203 0.20073919034976762 0.7697447462747161 0.05809032847914322 0.13411841984060763 1.5328856728178897e-07 6.814490234914614 0.5975204315516307 TASALFAGFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TASALFAGFR 10 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 8938400.0 2929900.0 3221700.0 2786800.0 False True 4013163.2075703647 3079354.641262786 2128615.2359476006 1.0 0.7673135833234846 0.5304083402170676 21.936308398246595 -6.970901181301752 0.23567047391417711 1.0897668630794897 0.20113931353720108 0.9999885825163529 0.0006477665856651575 0.07601135480433037 0.007976307344247972 0.0058407663882160165 0.02327796931271749 1.0692981580017202e-07 6.970901181301752 -0.8886275495422886 TASALFAGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TASALFAGFR 10 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 5848600.0 1812200.0 1290100.0 2746300.0 False True 1506924.5940721727 1283149.9752351989 3320538.632543494 1.0 0.8515024443046177 2.2035201002130966 20.52317579616042 -6.879663927768553 1.0816333705729309 0.9083587270437344 2.2987360863169126 0.9734150060410482 0.09870812332789511 0.12792998192589797 0.2740672452215807 0.07031763019865445 0.1699072548219865 1.3192772464428271e-07 6.879663927768553 1.3903773592731783 up TASDMVSTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TASDMVSTSR 10 0 O00232 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 0 2995460.0 760060.0 1136100.0 1099300.0 False True 996446.020431509 966598.3084831152 985554.9812302006 1.0 0.97004583154894 0.9890701162150338 19.92643212780512 -10.0785870145906 4.7598271258336435 1.0000008409252554 0.979557973881677 0.6062162055907169 0.007766631693296688 6.9311693515912e-08 1.3420165536833188e-08 0.007520318202127654 0.0025066696002041225 8.344743375009611e-11 10.0785870145906 -0.02044286704357845 TASDMVSTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TASDMVSTSR 10 0 O00232 O00232 PSMD12 26S proteasome non-ATPase regulatory subunit 12 0 2134710.0 760060.0 572050.0 802600.0 False True 1041074.7218491841 546774.9394836199 613042.4100658626 1.0 0.5252023971078886 0.5888553407357356 19.989642189328013 -10.410170603194524 5.940737663526127 1.00013878857319 0.557028868921992 0.9847498766212985 0.025986205419062047 4.7782995051934205e-05 4.744139612137203e-06 0.025168826856959668 0.00838701173492923 3.888923470367835e-11 10.410170603194524 -0.44310991965119806 TASGSSVTSLDGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TASGSSVTSLDGTR 14 0 Q92597;Q92597-3;Q92597-2;E5RJY1;E7ESM1 Q92597 NDRG1 Protein NDRG1 0 4017590.0 435190.0 2391000.0 1191400.0 False True 570538.3043859543 2034272.1200450002 1068125.3567157828 1.0 3.565531191169363 1.8721361011253397 19.121964222813283 -10.440689125227294 6.250997643076693 0.9994517630407229 2.7188336461472256 0.578715614123805 0.6913256505903723 0.005283576751772029 0.000472748521736278 0.6695446696661892 0.22312439429520992 3.625023904396211e-11 10.440689125227294 1.7193818831065026 TASGSSVTSLDGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TASGSSVTSLDGTR 14 0 Q92597;Q92597-3;Q92597-2;E5RJY1;E7ESM1 Q92597 NDRG1 Protein NDRG1 0 1563980.0 1067400.0 496580.0 0.0 False True 1033515.9712652192 694866.9836304892 0.0 1.0 0.6723330871992627 0.0 19.979129252704944 -7.485705128829826 0.721374370006228 0.9926550404298633 3.9865626695953516e-17 0.9871161516944966 0.04724762083561575 0.11837346858367159 0.1418243355955117 0.041595791823445055 0.07523757848918322 3.268096494882731e-08 7.485705128829826 -0.9926550404298633 down TASGSSVTSLDGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TASGSSVTSLDGTR 14 0 Q92597;Q92597-3;Q92597-2;E5RJY1;E7ESM1 Q92597 NDRG1 Protein NDRG1 0 3413590.0 435190.0 1532300.0 1446100.0 False True 596091.5035675425 1464597.9193615087 1104560.9633643706 1.0 2.457001837127438 1.853005715991075 19.185174284336174 -9.928938659356852 5.3982313000760564 0.999998091278109 2.155003776564449 0.8298076000447698 0.24658038391894882 5.6649327090638465e-06 1.1236695284926044e-06 0.23875082485806692 0.0795834766989902 1.1777723127499668e-10 9.928938659356852 1.15500568528634 TASNVEEAFINTAK(ub)EIYEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TASNVEEAFINTAKEIYEK 19 1 H7C125;P61019-2;P61019 H7C125 RAB2A Ras-related protein Rab-2A 1 7233000.0 3465500.0 2095300.0 1672200.0 True False 2881716.7976807877 2084012.2030155114 2021849.2886207707 1.0 0.7231842506844285 0.7016127643937669 21.45849713014659 -13.999999999999984 0.36185624927767707 4.664083822156917 0.6990839867575344 0.9997766319097356 0.002030523257038292 21.898230807134155 0.19455731195391163 62.015567189584225 0.006187266284172344 1.0000000000000368e-14 13.999999999999984 -3.964999835399383 TASPLEHILQTLFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TASPLEHILQTLFGK 15 0 Q9BTC0 Q9BTC0 DIDO1 Death-inducer obliterator 1 0 640190000.0 311180000.0 167840000.0 161170000.0 False True 402828644.2748362 158499556.45678243 131838713.74385072 1.0 0.39346644959200966 0.3272823708482401 28.58559103301946 -13.999999999999998 0.3128359827210979 6.961252659365151 0.31306639759792043 0.9996782119630375 0.005430514885701914 17.474143154629964 0.17807201145459517 67.91296183641681 0.022671864814788393 1.0000000000000041e-14 13.999999999999998 -6.648186261767231 TASPWK(ub)SAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TASPWKSAR 9 1 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 1 6526600.0 1213500.0 2513200.0 2799900.0 True False 1840968.2187334031 2064699.8242787747 2246498.5377602326 1.0 1.1215293144491654 1.220280999367733 20.81203329048702 -6.973488831893386 0.15343740172653048 0.8905784883651728 1.4538368171934335 0.9999983876931009 0.0001142467791662935 0.075186012732221 0.00470559017802205 0.004871074501096005 0.012150503977393846 1.062945917126769e-07 6.973488831893386 0.5632583288282607 TASPWK(ub)SAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TASPWKSAR 9 1 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 1 2493530.0 1055400.0 679890.0 758240.0 True False 1445609.9011125835 649850.2117044295 579159.3284429844 1.0 0.4495335921566986 0.4006332054015724 20.463246861821606 -13.999999999999998 0.34270506751205315 7.472809696312322 0.393210099017344 0.9997405674220664 0.0043770904034301636 19.954858884743075 0.18795680570961576 93.69729265935985 0.014964160332281916 1.0000000000000041e-14 13.999999999999998 -7.079599597294978 TASPWK(ub)SAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TASPWKSAR 9 1 Q13813;A0A0D9SGF6;Q13813-2;Q13813-3;A0A0D9SF54 Q13813 SPTAN1 Spectrin alpha chain, non-erythrocytic 1 1 5640600.0 1213500.0 1519600.0 2907500.0 True False 1570899.671661141 1435032.9241642426 2378364.8334692926 1.0 0.9135102324178177 1.5140144697810656 20.58315961257947 -6.870361119395046 1.1322488829607331 0.9509807644413779 1.54941524425517 0.9650389573714344 0.04956001007525725 0.1365056578464369 0.32686222403039694 0.03396380132097651 0.08045763609135509 1.3478416751909935e-07 6.870361119395046 0.5984344798137922 TASTPTPPQTGGGLEPQANGETPQVAVIVRPDDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TASTPTPPQTGGGLEPQANGETPQVAVIVRPDDR 34 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7;C9J556;C9JWH7;C9JSU8;C9JWW9 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 18712400.0 4133500.0 6558300.0 8020600.0 False True 5419058.528870938 5579827.204053173 7190705.251027869 1.0 1.0296672704909373 1.3269288775380792 22.36961079844772 -6.926161642229119 0.7776369176249462 0.9947791856598682 1.3823926090735197 0.9957290005217767 0.009647443225036917 0.09467986403744746 0.0878020241699579 0.008596386580494032 0.02748639256227199 1.1853274931047065e-07 6.926161642229119 0.38761342341365146 TASTPTPPQTGGGLEPQANGETPQVAVIVRPDDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TASTPTPPQTGGGLEPQANGETPQVAVIVRPDDR 34 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7;C9J556;C9JWH7;C9JSU8;C9JWW9 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 16849200.0 4164500.0 3212700.0 9472000.0 False True 4032300.227032046 4495547.864009167 6990999.046090974 1.0 1.1148842127060792 1.733749634817411 21.94317162877837 -6.93815773730728 0.6764891614455251 0.9927823341904826 1.8919637740359325 0.9979124621866888 0.014723275393908709 0.08861726576092101 0.0585137556604639 0.014139325401678891 0.05371120960415384 1.1530343955480532e-07 6.93815773730728 0.89918143984545 TASTPTPPQTGGGLEPQANGETPQVAVIVRPDDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TASTPTPPQTGGGLEPQANGETPQVAVIVRPDDR 34 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7;C9J556;C9JWH7;C9JSU8;C9JWW9 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 20826100.0 4133500.0 7130300.0 9562300.0 False True 5661766.6536373515 6815259.769251042 7303881.681750301 1.0 1.203733778903205 1.2900358012914552 22.43282085997061 -13.999999999999998 0.11748173843434465 0.02687756931907873 1.4325716240834452 0.9997053812217345 0.002087168857762839 11.974062477750232 0.10515240463372151 2.73002026203134 0.12647581909130187 1.0000000000000041e-14 13.999999999999998 1.4056940547643664 TASTPTPPQTGGGLEPQANGETPQVAVIVRPDDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TASTPTPPQTGGGLEPQANGETPQVAVIVRPDDR 34 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7;C9J556;C9JWH7;C9JSU8;C9JWW9 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 10545700.0 4164500.0 3608500.0 2772700.0 False True 3462966.2686312557 3589060.294268827 3352458.750483682 1.0 1.0364121437681257 0.9680887685367919 21.723576904212646 -6.761906604331382 1.6050881444115817 1.021099790519197 0.9678135520135486 0.6987821446198551 0.015319617254193615 0.27972541000736545 1.4207274625718327 0.007528774127253447 0.01806041840392117 1.7301883987758304e-07 6.761906604331382 -0.0532862385056484 TASVFLLEK(ub)DR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TASVFLLEKDR 11 1 Q96J01;Q96J01-2;D6RGZ2 Q96J01 THOC3 THO complex subunit 3 1 5989200.0 0.0 2694100.0 3295100.0 True False 0.0 3769868.179545899 2432014.459118915 0.0 TASVFLLEK(ub)DR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TASVFLLEKDR 11 1 Q96J01;Q96J01-2;D6RGZ2 Q96J01 THOC3 THO complex subunit 3 1 36515100.0 6579300.0 4534100.0 25401700.0 True False 9981279.111258905 3724954.429915004 20381042.86103936 1.0 0.37319409550557975 2.041926954837832 23.250793279598337 -6.8049527189627765 1.4355639299415948 0.656304391362797 2.0678913441011586 0.846260308687776 0.26985962277650505 0.21376327160066574 0.8691223307641219 0.1478489684591521 0.3428651684530393 1.5669216494069028e-07 6.8049527189627765 1.4115869527383618 up TASVFLLEK(ub)DR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TASVFLLEKDR 11 1 Q96J01;Q96J01-2;D6RGZ2 Q96J01 THOC3 THO complex subunit 3 1 6263400.0 0.0 3501700.0 2761700.0 True False 0.0 3482835.647066973 3339158.70134194 0.0 TASVFLLEK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TASVFLLEKDR 11 1 Q96J01;Q96J01-2;D6RGZ2 Q96J01 THOC3 THO complex subunit 3 1 37371000.0 6579300.0 5387900.0 25403800.0 True False 8517033.547391964 5088058.628655257 20780569.064999912 1.0 0.5973979790432189 2.4398834346922604 23.021919601690787 -6.849446607515237 1.2376551660637747 0.7852406919605395 2.5127963595276652 0.9395063278441317 0.19453241568953988 0.1580706668327592 0.46620447836381496 0.12300435898264815 0.2845584123210238 1.414338594214802e-07 6.849446607515237 1.7275556675671258 up TASVLWPWINR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TASVLWPWINR 11 0 D3YTB5;P51617-4;P51617-2;P51617-3;P51617;F8WAB6;H7C1F0 D3YTB5 IRAK1 Interleukin-1 receptor-associated kinase 1 0 7168200.0 1637200.0 2310000.0 3221000.0 False True 2146385.054667355 1965357.0043094752 2887721.8180137128 1.0 0.9156590985553916 1.3453885227789426 21.033477483548683 -6.8557513136626325 1.2069526056181235 0.9546608554047925 1.3645774825456793 0.9482698002963207 0.04228464355079116 0.15124452628664328 0.42108902963270095 0.02736749282268284 0.06361120534768602 1.3939547828668227e-07 6.8557513136626325 0.40991662714088684 TASVLWPWINR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TASVLWPWINR 11 0 D3YTB5;P51617-4;P51617-2;P51617-3;P51617;F8WAB6;H7C1F0 D3YTB5 IRAK1 Interleukin-1 receptor-associated kinase 1 0 5191000.0 1637200.0 1306700.0 2247100.0 False True 2242517.0836664047 1248965.6733209437 1716381.2604772002 1.0 0.5569481197792913 0.7653815763450067 21.096687545071575 -10.076346827690635 4.9561019309167405 1.0000080462963397 0.6611648480625356 0.7789348261569189 0.08509260232714433 8.423942047757502e-06 1.5698710766186736e-06 0.08239273503929312 0.027463519306948587 8.38789861164022e-11 10.076346827690635 -0.33884319823380404 TASWLAAELSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TASWLAAELSK 11 0 Q9NUU7;I3L0H8;F6QDS0;Q9UMR2;H3BQK0;Q9UMR2-4;Q9UMR2-2;Q9NUU7-2;I3L352;Q9UMR2-3 Q9NUU7 DDX19A;DDX19B ATP-dependent RNA helicase DDX19A;ATP-dependent RNA helicase DDX19B 0 9165500.0 2299800.0 3322500.0 3543200.0 False True 3015060.071294877 2826795.9510035617 3176583.6527743507 1.0 0.9375587497961652 1.0535722598091068 21.52375531562727 -6.76048553408522 1.6103997425566676 0.9637535643234943 1.0540101174931455 0.693067926563036 0.026264956302802938 0.28208807881423087 1.441910550582279 0.012867114640280293 0.030909895649604262 1.7358590816381833e-07 6.76048553408522 0.0902565531696512 TATESFASDPILYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TATESFASDPILYR 14 0 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 47246100.0 7337100.0 20131000.0 19778000.0 False True 9619009.152577477 17127533.270023413 17731562.283972435 1.0 1.7805922625028356 1.8433876091303174 23.197456859963395 -11.167440423540002 0.4386541765516319 1.5119414031397378e-20 1.8447557933698804 0.9996838623977186 0.006821095917310742 3.1651605345160174 0.2152258357996816 3.1309967283990443 0.01452959453238159 6.800793317980718e-12 11.167440423540002 1.8447557933698804 TATESFASDPILYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TATESFASDPILYR 14 0 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 40211400.0 13399000.0 7351400.0 19461000.0 False True 12973656.079241786 10286852.357044555 14363580.28251441 1.0 0.7929031179964612 1.1071343493910357 23.62908176400996 -6.728956219139386 1.7270624675791526 0.8752249243622654 1.1069110068579642 0.554403956107657 0.0870659951515565 0.33820053776700987 1.9757896217656983 0.039958245498088504 0.09927005928378395 1.8665678484818082e-07 6.728956219139386 0.23168608249569878 TATESFASDPILYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TATESFASDPILYR 14 0 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 42459100.0 7337100.0 17232000.0 17890000.0 False True 10049824.147672106 16470633.261396274 13664750.45611547 1.0 1.6388976582452395 1.3597004539906012 23.260666921486287 -9.99308033721391 4.362850942298076 0.9999806041956576 1.4992990560835469 0.8100377987782375 0.11398178175113882 7852188.27172499 5140695.293142034 1352.543530177151 0.03901899515784966 1.016060721249515e-10 9.99308033721391 0.49931845188788926 TATESFASDPILYRPVAVALDTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TATESFASDPILYRPVAVALDTK 23 1 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 580345600.0 125093300.0 274460600.0 180791700.0 False True 163998527.70524055 233512148.31903973 162085109.1604438 1.0 1.4238673455577484 0.9883327090092188 27.28910762222346 -8.87575073084196 18.027061807874293 1.0000006596696074 1.2061000272834836 0.22992347798562374 0.17780627080914505 0.0 0.0 0.17216018142358186 0.05738672714119394 1.3312182693729256e-09 8.87575073084196 0.20609936761387626 TATESFASDPILYRPVAVALDTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TATESFASDPILYRPVAVALDTK 23 1 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 729226000.0 217261900.0 177690800.0 334273300.0 False True 210365039.90765134 248643663.08528078 246717094.74595442 1.0 1.181962854637983 1.172804639279708 27.648319725408708 -10.319385246144115 5.339301208855702 0.999958800991299 1.1773837469588149 0.9980047883185313 0.003738825763745732 1.8341272830138146e-06 2.337942302794636e-07 0.0036209423464251813 0.0012067008264422027 4.793080840008679e-11 10.319385246144115 0.1774249459675159 TATESFASDPILYRPVAVALDTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TATESFASDPILYRPVAVALDTK 23 1 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 1675485000.0 230080000.0 1189089000.0 256316000.0 False True 349048181.10109645 976886777.5552387 205655030.25270653 1.0 2.798716138481462 0.5891880874553009 28.378850952662543 -6.690183907624877 1.865501175854057 2.127437012927595 0.5967278018657665 0.37149609982750265 0.7606929675414796 0.41621801918853696 2.808423200242773 0.3261743520102411 0.8492656220780598 2.040873527322343e-07 6.690183907624877 -1.5307092110618286 TATESFASDPILYRPVAVALDTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TATESFASDPILYRPVAVALDTK 23 1 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 664981900.0 125093300.0 219008500.0 320880100.0 False True 171343673.52932242 209331980.30573982 245094829.11310145 1.0 1.221708254491908 1.430428238549221 27.352317683746353 -6.971854951217498 0.2091923909065067 0.8895907384634113 1.7683671263650718 0.9999934620988009 0.0004493392521966159 0.07570531766807173 0.0068328428795629195 0.00629046871626769 0.021669052176188298 1.066952410138939e-07 6.971854951217498 0.8787763879016605 TATESFASDPILYRPVAVALDTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TATESFASDPILYRPVAVALDTK 23 1 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 481518500.0 217261900.0 149524500.0 114732100.0 False True 180662896.1841127 148718981.84021065 138722051.64870676 1.0 0.8231849758937322 0.7678502591220268 27.428725000842984 -13.9999999999871 0.16263455723287273 1.8758130220973988 0.7150043332226006 0.9995296847566941 0.0021471022829500372 12.028294017448887 0.127526596118123 3.322603655777936 0.04832869367572285 1.0000000000297031e-14 13.9999999999871 -1.1608086888747982 TATESFASDPILYRPVAVALDTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TATESFASDPILYRPVAVALDTK 23 1 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 703948000.0 230080000.0 271878000.0 201990000.0 False True 297843095.554837 256747750.3000306 165229892.5924205 1.0 0.8620235087932727 0.554754819092321 28.149977274754992 -6.957889363854917 0.4642237082201821 1.0085883905863722 0.39571520865234483 0.9996837319348992 0.003309562259929547 0.08046386112429936 0.023983622629708722 0.004203830156543589 0.025372632363776227 1.1018199614778529e-07 6.957889363854917 -0.6128731819340274 TATESFASDPILYRPVAVALDTK(ub)GPEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TATESFASDPILYRPVAVALDTKGPEIR 28 2 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 42213000.0 12485000.0 19128000.0 10600000.0 True False 16367955.90491198 16274176.960360002 9503213.682379799 1.0 0.9942705769066842 0.5805986854795906 23.964370827808533 -6.909917615968405 0.8962973221091743 1.0128414879988408 0.5272329352751816 0.9908904055487203 0.018742487320504084 0.1044724685658813 0.13906355044112992 0.015338478584510767 0.04231692179599007 1.2305021703129517e-07 6.909917615968405 -0.4856085527236592 TATESFASDPILYRPVAVALDTK(ub)GPEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TATESFASDPILYRPVAVALDTKGPEIR 28 2 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 287090100.0 114848400.0 93449700.0 78792000.0 True False 111202600.40683582 130764652.54374747 58154011.4906672 1.0 1.1759136213123045 0.5229554999425389 26.728615284122384 -6.834975132099583 1.3054804905172481 1.0937242114237318 0.5035232883461581 0.9154729713088626 0.08020123390808881 0.1747497034465634 0.5806702416693652 0.04820811673808156 0.1109595975984897 1.4622609017867518e-07 6.834975132099583 -0.5902009230775737 TATESFASDPILYRPVAVALDTK(ub)GPEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TATESFASDPILYRPVAVALDTKGPEIR 28 2 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 698789000.0 146199000.0 185811000.0 366779000.0 True False 221794571.57857808 152651575.30203053 294284969.8850532 1.0 0.6882565890389641 1.326835764241385 27.72464881507416 -6.773921155694756 1.5591331722258284 0.8220952969948233 1.3310017642268892 0.7454713643472676 0.13153698359181085 0.26011800518674877 1.248354693982585 0.06647421081991312 0.15769415727779515 1.6829795710788216e-07 6.773921155694756 0.5089064672320659 TATESFASDPILYRPVAVALDTK(ub)GPEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TATESFASDPILYRPVAVALDTKGPEIR 28 2 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 96955200.0 12485000.0 32259200.0 52211000.0 True False 17101041.89443869 30833881.87709112 39879837.11929823 1.0 1.803041128571142 2.3320121291713383 24.027580889331425 -8.338562768775146 0.14290174428093572 6.1857147782928435e-15 3.4047377595219364 0.9999292473341052 0.00460623996328434 0.10012434508506485 0.03220572295043015 0.35250713112791926 0.3412299465467402 4.586033588601029e-09 8.338562768775146 3.40473775952193 TATESFASDPILYRPVAVALDTK(ub)GPEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TATESFASDPILYRPVAVALDTKGPEIR 28 2 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 237809300.0 114848400.0 66363600.0 56597300.0 True False 95501533.24679323 66006086.114656694 68431533.75365175 1.0 0.6911521089832666 0.7165490587131444 26.50902055955666 -10.77817516858777 7.003037596638504 1.0082806267830366 0.7038505838486463 0.9945145294532213 0.010368261310219298 0.0013538465172979743 4.28837420027743e-05 0.01013919585178606 0.0033463419486338426 1.6665748796937578e-11 10.77817516858777 -0.30443004293439035 TATESFASDPILYRPVAVALDTK(ub)GPEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TATESFASDPILYRPVAVALDTKGPEIR 28 2 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 670876000.0 146199000.0 162697000.0 361980000.0 True False 189257487.51313302 153642768.92784292 296103354.22844905 1.0 0.81181870765975 1.5645529173999086 27.49577513716661 -6.840516624193086 1.2801354389040693 0.8999022985968517 1.5895430075190358 0.9253155783849629 0.08741027635205174 0.16819777169139083 0.5352199754412883 0.05353959776170606 0.12335259492484603 1.4437213395736515e-07 6.840516624193086 0.6896407089221841 TATESFASDPILYRPVAVALDTKGPEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TATESFASDPILYRPVAVALDTKGPEIR 28 2 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 46781800.0 2824800.0 31982000.0 11975000.0 False True 4285428.120542323 26274562.2234935 9608136.001171047 1.0 6.131140573224325 2.2420481060256665 22.03100790820812 -6.575687503156726 2.2834037599732704 4.50310864205018 2.2508607459269614 0.0 2.231525147860373 0.7124165506473323 6.980175222778302 0.8227320708550133 2.4979898450731794 2.656516372308452e-07 6.575687503156726 -2.252247896123219 TATESFASDPILYRPVAVALDTKGPEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TATESFASDPILYRPVAVALDTKGPEIR 28 2 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 26738000.0 2824800.0 6734200.0 17179000.0 False True 3656759.285132579 6359435.850162444 14052598.271425266 1.0 1.739090641273063 3.842910395704588 21.80213423030057 -6.9526259304487095 0.5292401115578765 0.9666374865482877 4.710743015429268 0.9993915184790945 0.02970857066773251 0.0824483066611255 0.0317299804304108 0.03318159749976432 0.1739574322425651 1.1152547189862988e-07 6.9526259304487095 3.7441055288809806 TATPQQAQEVHEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TATPQQAQEVHEK 13 0 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 0 97148000.0 11189000.0 48380000.0 37579000.0 False True 14668887.354430145 41161892.58376297 33690685.563221745 1.0 2.8060678079535246 2.2967444462000612 23.806256109924785 -10.128090697069926 4.899854681579031 0.9999171145470988 2.551406127083638 0.9252109180532315 0.2079303917528367 0.00018828770022697407 3.3506163204508644e-05 0.2013383131060797 0.0671092453657167 7.445764620166015e-11 10.128090697069926 1.551489012536539 TATPQQAQEVHEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TATPQQAQEVHEK 13 0 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 0 98919000.0 34152000.0 17618000.0 47149000.0 False True 33067863.453859694 24652959.27665629 34799262.460319154 1.0 0.7455262209805329 1.0523589620138392 24.97892649885163 -6.686536320219522 1.8790329323697752 0.8399441874396699 1.051247972189509 0.3541599815406775 0.10770154924861249 0.4241365210370523 2.9007305145427047 0.04590350951313068 0.1200467788733474 2.0580867647334483e-07 6.686536320219522 0.21130378474983902 TATPQQAQEVHEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TATPQQAQEVHEK 13 0 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 0 238596000.0 28025000.0 185900000.0 24671000.0 False True 42515973.90193953 152724692.5566706 19794766.036316585 1.0 3.592172036536683 0.4655842079960814 25.341501649916037 -6.686601575210024 1.8788074791750438 2.630285596311552 0.4768958795337734 0.3544801293445884 1.0970744463009414 0.42398348833711247 2.899042774320509 0.4676325702224121 1.2228478703565182 2.0577775497912407e-07 6.686601575210024 -2.1533897167777787 TATPQQAQEVHEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TATPQQAQEVHEK 13 0 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 0 98342000.0 11189000.0 45352000.0 41801000.0 False True 15325875.671355607 43348198.68099145 31928464.71861836 1.0 2.8284320981417177 2.0833044325351895 23.869466171447677 -10.497064052277894 5.942313632162843 0.9985054208179056 2.455868265338453 0.8357975681711571 0.30419709566119507 0.006026901967615878 0.0005100949685749722 0.2947158272497786 0.09817919045503924 3.1837279323725285e-11 10.497064052277894 1.4573628445205475 TATPQQAQEVHEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TATPQQAQEVHEK 13 0 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 0 54580300.0 34152000.0 14406000.0 6022300.0 False True 28398901.190129638 14328392.01863287 7281535.086030904 1.0 0.5045403666397088 0.25640200081268233 24.759331774285908 -9.594865200365877 0.18984775454760344 1.5403753261945694 7.654780183102931e-25 0.999545774926827 0.006588113210876845 1.029494123342637 0.07736992915000533 0.4591192608244429 0.1516931105206955 2.541761514452306e-10 9.594865200365877 -1.5403753261945694 TATPQQAQEVHEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TATPQQAQEVHEK 13 0 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 0 74260000.0 28025000.0 22817000.0 23418000.0 False True 36278914.95533867 21547213.892245002 19156164.288971238 1.0 0.5939321481574298 0.5280247304130656 25.112627972008486 -13.999999999999998 0.2558869449498542 3.9099566220545494 0.502969830684896 0.9995540593712393 0.0044071462056533665 14.23916367010965 0.16006763551723122 21.373261978825184 0.029451853397257515 1.0000000000000041e-14 13.999999999999998 -3.406986791369653 TATPQQAQEVHEK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TATPQQAQEVHEKLR 15 1 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 1 2258310.0 655420.0 670770.0 932120.0 True False 859261.9670963086 570693.7306409816 835673.163926402 1.0 0.6641673348693863 0.9725476000647161 19.7127385138482 -10.415006368202787 8.300739512998422 1.000002531266141 0.8183574679921806 0.3162836005829943 0.1258957160787861 5.897470962947318e-06 4.1578193768437935e-07 0.12189970102131528 0.04063266764433298 3.845861426909428e-11 10.415006368202787 -0.18164506327396035 TATPQQAQEVHEK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TATPQQAQEVHEKLR 15 1 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 1 4241100.0 1040000.0 1344400.0 1856700.0 True False 1006985.7692672183 1881225.9309533814 1370374.5701939506 1.0 1.8681752894306998 1.3608678613116545 19.941611864632446 -10.404739831587214 5.225111969050346 0.9995233099330927 1.6145215753711968 0.6617574316706174 0.20710739026928765 0.0011509364347242227 0.00013111784753168715 0.2006797403418962 0.06684362278244278 3.9378590615945365e-11 10.404739831587214 0.6149982654381041 TATPQQAQEVHEK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TATPQQAQEVHEKLR 15 1 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 1 13430500.0 1811500.0 5448400.0 6170600.0 True False 2748177.9383894135 4476090.451456505 4950978.20532994 1.0 1.6287484114219128 1.8015493597301384 21.39004398778917 -11.210273432375123 0.2393767713291954 2.119099223660091e-12 1.8922915436349168 0.9992767750321894 0.00926260394935582 3.3856841925052277 0.13157721253871182 1.8972907752189903 0.08406749980077596 6.162069150228263e-12 11.210273432375123 1.8922915436327976 TATPQQAQEVHEK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TATPQQAQEVHEKLR 15 1 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 1 2534140.0 655420.0 567020.0 1311700.0 True False 897746.4860595124 541967.1815156057 1001903.475309484 1.0 0.6036973576966785 1.116020492274104 19.775948575371093 -6.700181926670959 1.8303156073432927 0.7539519208938092 1.1144959507356018 0.41836928882294366 0.1672792652464838 0.39515959191057415 2.5738207994785185 0.07290998057120916 0.18745653392373018 1.9944266713502351e-07 6.700181926670959 0.36054402984179257 TATPQQAQEVHEK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TATPQQAQEVHEKLR 15 1 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 1 3851200.0 1040000.0 1381900.0 1429300.0 True False 864806.0798118642 1374455.4304143263 1728160.0216634783 1.0 1.5893221179866528 1.998320851351362 19.722017140066722 -7.773378867198145 0.11026309324955284 8.900536110699916e-14 3.2697086209232227 0.9999908394585177 0.001240221293667972 0.13524095706861233 0.014484242141804415 0.17779142383897317 0.22966089790728372 1.6850823620202073e-08 7.773378867198145 3.269708620923134 TATPQQAQEVHEK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TATPQQAQEVHEKLR 15 1 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 1 9898400.0 1811500.0 2176900.0 5910000.0 True False 2345022.460003421 2055753.6013511077 4834440.641720905 1.0 0.8766455914235075 2.0615754109723334 21.16117030988162 -6.881202461089771 1.0731116476629217 0.9222692026120008 2.14749725778086 0.9746407366151252 0.08470222080376667 0.1265683839983769 0.2659173811554726 0.06073720928823331 0.14733206109225336 1.3146118384624033e-07 6.881202461089771 1.2252280551688592 up TAVAHRPGAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAVAHRPGAFK 11 1 Q969H8 Q969H8 MYDGF Myeloid-derived growth factor 0 40976200.0 7595200.0 17057000.0 16324000.0 False True 9957380.752021438 14512162.087665249 14634949.070864908 1.0 1.4574276558340054 1.4697589090277463 23.24733486653503 -11.5738597123725 0.5739122374555531 8.813225483949558e-09 1.4684579356229426 0.9999398904545456 0.0016947875943200536 4.828550658715409 0.2843449890122468 6.010444542703363 0.002223558149787509 2.667720263558783e-12 11.5738597123725 1.468457926809717 TAVAHRPGAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAVAHRPGAFK 11 1 Q969H8 Q969H8 MYDGF Myeloid-derived growth factor 0 46934000.0 16751000.0 12627000.0 17556000.0 False True 16219248.674033806 17669026.948935103 12957556.931289384 1.0 1.0893862782449546 0.7988999485551865 23.951203655200093 -6.824088397079742 1.354072325490437 1.047989921168477 0.7919836648415082 0.8935334140383127 0.039637515631024745 0.18822164926517232 0.676966747061558 0.022996343523009444 0.05295456659482892 1.499379618017716e-07 6.824088397079742 -0.2560062563269687 TAVAHRPGAFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAVAHRPGAFK 11 1 Q969H8 Q969H8 MYDGF Myeloid-derived growth factor 0 36875000.0 0.0 26424000.0 10451000.0 False True 0.0 21708430.74834566 8385355.269163974 0.0 TAVAHRPGAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAVAHRPGAFK 11 1 Q969H8 Q969H8 MYDGF Myeloid-derived growth factor 0 41560200.0 7595200.0 16332000.0 17633000.0 False True 10403350.692562351 15610398.237298273 13468448.563034335 1.0 1.500516391171797 1.2946260258883044 23.310544928057922 -10.092431699566736 4.495728552757847 0.9999693371826625 1.39757120837153 0.8325408075197078 0.08405438972489593 12935443.512523647 14519347.79720034 3423.233543292053 0.028774054313462753 8.082920372333242e-11 10.092431699566736 0.3976018711888675 TAVAHRPGAFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAVAHRPGAFK 11 1 Q969H8 Q969H8 MYDGF Myeloid-derived growth factor 0 17679700.0 0.0 6428700.0 11251000.0 False True 0.0 6070937.1937185265 9203433.445008779 0.0 TAVAPIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAVAPIER 8 0 P05141;Q9H0C2;P12236;V9GYG0;P12235 P05141;P12236 SLC25A5;SLC25A31;SLC25A6;SLC25A4 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed;ADP/ATP translocase 4;ADP/ATP translocase 4, N-terminally processed;ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed;ADP/ATP translocase 1 0 8226600.0 1275700.0 3813600.0 3137300.0 False True 1672455.053896375 3244625.7452963726 2812682.2911066185 1.0 1.9400376337392495 1.6817685381462524 20.673536009253922 -10.044079500279276 5.012494949262888 0.9999872381863842 1.8109030859461412 0.9292992790776342 0.1054379167744663 1.5441345998785595e-05 2.944583757693806e-06 0.10209147057361288 0.03402994130780835 9.034840702610319e-11 10.044079500279276 0.810915847759757 TAVAPIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAVAPIER 8 0 P05141;Q9H0C2;P12236;V9GYG0;P12235 P05141;P12236 SLC25A5;SLC25A31;SLC25A6;SLC25A4 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed;ADP/ATP translocase 4;ADP/ATP translocase 4, N-terminally processed;ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed;ADP/ATP translocase 1 0 9495900.0 1275700.0 4732600.0 3487600.0 False True 1747360.764496233 4523498.08338464 2663900.709376651 1.0 2.5887602464787927 1.5245281704288798 20.736746070776814 -10.516943641376912 5.307684407334472 0.9971158484680244 2.0566442084538417 0.5679203405265509 0.43447092570420365 0.014849980498901625 0.0013515074748756124 0.42129530897575757 0.1402248883053057 3.0412796685296455e-11 10.516943641376912 1.0595283599858174 TAVAPIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAVAPIER 8 0 P05141;Q9H0C2;P12236;V9GYG0;P12235 P05141;P12236 SLC25A5;SLC25A31;SLC25A6;SLC25A4 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed;ADP/ATP translocase 4;ADP/ATP translocase 4, N-terminally processed;ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed;ADP/ATP translocase 1 0 5777700.0 1870200.0 2873400.0 1034100.0 False True 1555154.1639078336 2857920.423874755 1250325.5288618233 1.0 1.8377087559559335 0.8039881562095241 20.568626172497428 -6.691136717945205 1.8625194737125723 1.524631739174681 0.8075237803668007 0.3757111551557061 0.354210467124558 0.4142160986405482 2.7868245640577727 0.15209526628885925 0.3954792679699544 2.0364009082071984e-07 6.691136717945205 -0.7171079588078804 TAVAPIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAVAPIER 8 0 P05141;Q9H0C2;P12236;V9GYG0;P12235 P05141;P12236 SLC25A5;SLC25A31;SLC25A6;SLC25A4 ADP/ATP translocase 2;ADP/ATP translocase 2, N-terminally processed;ADP/ATP translocase 4;ADP/ATP translocase 4, N-terminally processed;ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed;ADP/ATP translocase 1 0 9167100.0 2810600.0 2764100.0 3592400.0 False True 3638377.105208731 2610275.4051608206 2938620.061136749 1.0 0.7174284934411908 0.8076733049275723 21.794863650416712 -10.498379080311588 8.801445544274195 1.0000091323242029 0.7625508991843816 0.9022551124821995 0.03684229001254885 6.6023892462975684e-06 3.7631769833658875e-07 0.03567376442173097 0.011890797971228793 3.174102299364734e-11 10.498379080311588 -0.23745823313982128 TAVCDIPPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAVCDIPPR 9 0 P04350;A6NNZ2;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q3ZCM7;A0A075B736;Q5SQY0;Q9BVA1 P04350;P07437;P68371;Q13885;Q3ZCM7;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB8;TUBB2B Tubulin beta-4A chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-8 chain;Tubulin beta-2B chain 0 36117770.0 6010970.0 16274600.0 13832200.0 False True 7880439.880316284 13846493.11789393 12400976.631831499 1.0 1.7570710935159368 1.5736401546323049 22.90984473142191 -10.07673010704582 4.537978697452376 0.9999618732824659 1.6653556238942642 0.9460709830405049 0.07488536737215126 26003295.006210577 0.923207845645476 11678.240296559858 0.025635253061854487 8.38049927710921e-11 10.07673010704582 0.6653937506117983 TAVCDIPPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAVCDIPPR 9 0 P04350;A6NNZ2;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q3ZCM7;A0A075B736;Q5SQY0;Q9BVA1 P04350;P07437;P68371;Q13885;Q3ZCM7;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB8;TUBB2B Tubulin beta-4A chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-8 chain;Tubulin beta-2B chain 0 140312500.0 11098300.0 121178000.0 8036200.0 False True 16836932.494411957 99552839.13196465 6447841.547608416 1.0 5.912765829821165 0.3829582110487408 24.00512598324459 -6.672312932091741 1.9292798108653249 4.12950684900533 0.4050733069344057 0.2893684708294648 2.0857209904210863 0.4557724040139038 3.272780422364257 0.8696795821593988 2.316491087304499 2.1266061618273977e-07 6.672312932091741 -3.7244335420709245 TAVCDIPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAVCDIPPR 9 0 P04350;A6NNZ2;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q3ZCM7;A0A075B736;Q5SQY0;Q9BVA1 P04350;P07437;P68371;Q13885;Q3ZCM7;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB8;TUBB2B Tubulin beta-4A chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-8 chain;Tubulin beta-2B chain 0 29122670.0 6010970.0 9400400.0 13711300.0 False True 8233388.049356363 8985059.245034222 10472973.333087537 1.0 1.0912954899212628 1.2720125992247204 22.9730547929448 -6.960246134225062 0.4319514937264503 0.9929684643646859 1.3772921976288894 0.9997792154381767 0.0016794998977483582 0.07961332716588207 0.02080735376729103 0.002361051431852295 0.01499844032382287 1.0958569486717267e-07 6.960246134225062 0.38432373326420355 TAVCDIPPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAVCDIPPR 9 0 P04350;A6NNZ2;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q3ZCM7;A0A075B736;Q5SQY0;Q9BVA1 P04350;P07437;P68371;Q13885;Q3ZCM7;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB8;TUBB2B Tubulin beta-4A chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-8 chain;Tubulin beta-2B chain 0 7837620.0 6540700.0 503930.0 792990.0 False True 5438881.852139864 501215.22906772664 958800.5426285055 1.0 0.09215409392842931 0.17628633397345755 22.3748786560608 -10.391412976910289 7.526791461553955 1.0000227352551758 0.13422021400102385 0.9929675548303787 0.03434684317127814 1.3104137572860447e-05 1.0595353630335879e-06 0.033257055875860364 0.011085395966429849 4.060570200218628e-11 10.391412976910289 -0.865802521254152 TAVCDIPPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAVCDIPPR 9 0 P04350;A6NNZ2;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q3ZCM7;A0A075B736;Q5SQY0;Q9BVA1 P04350;P07437;P68371;Q13885;Q3ZCM7;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB8;TUBB2B Tubulin beta-4A chain;Tubulin beta-8 chain-like protein LOC260334;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-8 chain;Tubulin beta-2B chain 0 35448200.0 11098300.0 14535100.0 9814800.0 False True 14366968.130199281 13726208.90762024 8028607.108352347 1.0 0.9554005259305776 0.5588240354954406 23.77625230533704 -6.928185090865826 0.7615480854645879 1.0064544326370244 0.48104977779708924 0.9961692150096678 0.012273312665752543 0.09359148615396616 0.08237950076782881 0.011063111075636206 0.03624813473871336 1.1798177049669928e-07 6.928185090865826 -0.5254046548399351 TAVETAVLLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAVETAVLLLR 11 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 51698000.0 13145000.0 24149000.0 14404000.0 False True 17233222.296361074 20546063.332064748 12913612.252924422 1.0 1.1922357281031073 0.7493440304342404 24.038689148498367 -6.788715586349648 1.5012819077188728 1.1076181075980835 0.7447864164178549 0.7972097169533622 0.08165847191104621 0.23726021265492056 1.0564076726423448 0.042815054050369186 0.10034282585171898 1.6266136545554862e-07 6.788715586349648 -0.3628316911802286 TAVETAVLLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAVETAVLLLR 11 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 129702000.0 22279000.0 77806000.0 29617000.0 False True 33798871.813070804 63920911.39894738 23763186.968407746 1.0 1.891214350362656 0.7030763363887778 25.01047175519082 -6.705973982492103 1.8096225143943847 1.550135584310496 0.7061902252120014 0.4459640365356139 0.3757973950869752 0.38320912157274595 2.4436433058984592 0.16542161863993135 0.4223026775103293 1.9680041844369523e-07 6.705973982492103 -0.8439453590984947 TAVETAVLLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAVETAVLLLR 11 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 45380000.0 13145000.0 17286000.0 14949000.0 False True 18005061.730268054 16522247.36284215 11418354.084319176 1.0 0.9176445829711783 0.6341746701775504 24.10189921002126 -6.948327952693794 0.5769184852713487 1.0034290185453345 0.534443636420419 0.9990633694535536 0.0047954028654867715 0.08416440933213201 0.038796823069395005 0.005041237889056457 0.02366023494849427 1.1263465867365321e-07 6.948327952693794 -0.4689853821249155 TAVIDHHNYDISDLGQHTLIVADTENLLK(ub)APTIVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGK 36 1 A0A0C4DGS1;P39656;P39656-3;P39656-2;U3KQ84 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 1 62265200.0 5101200.0 20097000.0 37067000.0 True False 7738893.34767435 16510533.331422301 29740691.202956747 1.0 2.133448878240964 3.8430160317294275 22.883695846808852 -6.965165471214132 0.35520071402452724 0.8443696647474399 5.190246103362978 0.9999165162685931 0.010677183876062774 0.07790485296797783 0.014662183427468042 0.023174361361899893 0.1464491719539042 1.0835140040132787e-07 6.965165471214132 4.345876438615538 TAVIDHHNYDISDLGQHTLIVADTENLLK(ub)APTIVGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGK 36 1 A0A0C4DGS1;P39656;P39656-3;P39656-2;U3KQ84 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 1 63460200.0 5101200.0 13740000.0 44619000.0 True False 6603603.959685045 12975356.921569303 36498799.82960153 1.0 1.9648902327855764 5.527103086803273 22.6548221689013 -6.946718303918984 0.5937804452126143 0.9592638360348351 6.713142859851486 0.9989179385768389 0.06404387735305725 0.08483089581687851 0.04162679209270216 0.06614066167843742 0.2987684391673589 1.1305289710047647e-07 6.946718303918984 5.753879023816651 TAVLTAFANGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAVLTAFANGR 11 0 O96019;O96019-2;O94805 O96019 ACTL6A;ACTL6B Actin-like protein 6A;Actin-like protein 6B 0 28379700.0 8403100.0 8041600.0 11935000.0 False True 11016545.47573616 6841824.62591129 10700080.688604057 1.0 0.6210499145108914 0.971273682133014 23.39316856449571 -10.45423180305575 8.656433724828199 1.000003844849424 0.7961617993902327 0.3111369316805521 0.14297825441154477 1.0609516727091502e-05 6.690720318640441e-07 0.1384407093623724 0.04614603318381001 3.5137284652601524e-11 10.45423180305575 -0.20384204545919127 TAVLTAFANGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAVLTAFANGR 11 0 O96019;O96019-2;O94805 O96019 ACTL6A;ACTL6B Actin-like protein 6A;Actin-like protein 6B 0 22600000.0 8927100.0 2599900.0 11073000.0 False True 8643714.096947491 3638053.628299385 8172649.117120494 1.0 0.42089009278825584 0.9455020174726334 23.043219923134565 -10.503036200796545 9.067447781816076 1.0000098763684193 0.683196055130446 0.3271575591627126 0.21417192140935398 4.27624569541733e-05 2.343739305328373e-06 0.2073775269413477 0.06912369040363933 3.1402469263823815e-11 10.503036200796545 -0.3168138212379733 TAVLTAFANGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAVLTAFANGR 11 0 O96019;O96019-2;O94805 O96019 ACTL6A;ACTL6B Actin-like protein 6A;Actin-like protein 6B 0 24344500.0 8403100.0 8318600.0 7622800.0 False True 11509953.155238917 7951056.746068424 5822451.636493964 1.0 0.690798358501519 0.5058623226319382 23.4563786260186 -9.836580031347028 0.10216972669672113 1.7602514650999168 9.69879718685935e-14 0.9999321349324118 0.0016792793633000724 1.3781148610272065 0.04533010507633399 0.5330637729713623 0.2576347474296222 1.4568672099790887e-10 9.836580031347028 -1.7602514650998198 TAVMK(ub)ELYSFLHHQNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAVMKELYSFLHHQNR 16 1 P21128-3;P21128-2;P21128 P21128-3 ENDOU Poly(U)-specific endoribonuclease 1 285593000.0 101450000.0 95035000.0 89108000.0 True False 138958806.58316436 90836039.46128115 68062525.63686621 1.0 0.6536904115315455 0.4898036138222877 27.050082028047235 -13.999999999978272 0.09950176460910884 2.712792238634136 0.13803032023314368 0.9997962107572727 0.003036082535072322 12.084241860304965 0.09383888542792763 4.255507863569372 0.3138259132255477 1.0000000000500315e-14 13.999999999978272 -2.5747619184009922 TAVSCLSQNDWK(ub)LDVATDNFFQNPELYIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAVSCLSQNDWKLDVATDNFFQNPELYIR 29 1 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 168728000.0 64372000.0 56818000.0 47538000.0 True False 97657030.22357364 46678383.97893983 38142093.46335439 1.0 0.4779828331055682 0.39057191659456364 26.54122057011167 -13.999999999999998 0.2514507699920339 4.65709679546141 0.35590722364956945 0.9995454341042423 0.005736529326012106 14.055971684347695 0.15867382642603042 25.98663544148816 0.04001688930795147 1.0000000000000041e-14 13.999999999999998 -4.3011895718118405 TAVSCLSQNDWK(ub)LDVATDNFFQNPELYIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAVSCLSQNDWKLDVATDNFFQNPELYIR 29 1 Q96GG9;C9JVE2;C9JRU6;C9J0B2;C9J8R4 Q96GG9 DCUN1D1 DCN1-like protein 1;DCN1-like protein 1 96183000.0 64372000.0 9788000.0 22023000.0 True False 83330822.96182197 9243289.195656503 18015039.975062523 1.0 0.1109228118374796 0.21618699221674692 26.31234689220412 -10.453668859651101 6.004045649506577 1.0004387734431113 0.16355490202711676 0.9882613159662672 0.04297392168691623 0.0002525240391655445 2.29781130897966e-05 0.04162960373112874 0.013869773584553935 3.518286001420631e-11 10.453668859651101 -0.8368838714159945 TAVSGIRPENLK(ub)QGEELEVVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAVSGIRPENLKQGEELEVVQK 22 2 Q9GZR2 Q9GZR2 REXO4 RNA exonuclease 4 1 8853600.0 3746400.0 2859400.0 2247800.0 True False 3115297.5936607393 2843995.844653538 2717804.5873470735 1.0 0.9129130553821669 0.8724060882265255 21.57093855484997 -13.999999999956048 0.1023955515277738 1.4272266472428805 0.7892472896758235 0.9997816544884798 0.0007865986225423075 12.062661984637995 0.09577251850423395 1.08261077580804 0.07407187176737766 1.000000000101204e-14 13.999999999956048 -0.637979357567057 TAVVMK(ub)TCQEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAVVMKTCQEEK 12 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 10680500.0 3825500.0 4205100.0 2649900.0 True False 4952185.161878608 3971082.488420018 2167645.3902700897 1.0 0.8018848969923391 0.43771493177524784 22.239633827157842 -6.961660930400027 0.41135864114455095 1.0176756707390564 0.20837953693368857 0.9998269212293257 0.003063549136735062 0.07911308109629817 0.01897794680210021 0.004691249797967515 0.030392222022569332 1.0922927966032292e-07 6.961660930400027 -0.8092961338053678 down TAVVVGTITDDVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAVVVGTITDDVR 13 0 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 96075000.0 31615000.0 34355000.0 30105000.0 False True 41447571.160095476 29229367.914741114 26990023.387551352 1.0 0.7052130461840501 0.6511846806004538 25.304784226054316 -13.999999999999998 0.23862597327278892 2.9382981100367855 0.6269825909220029 0.9995227094298385 0.003348998860575732 13.575338174123914 0.15461661997468587 12.528685562570516 0.026615195217834346 1.0000000000000041e-14 13.999999999999998 -2.3113155191147827 TAVVVGTITDDVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAVVVGTITDDVR 13 0 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 62402000.0 19227000.0 12411000.0 30764000.0 False True 18616649.409327686 17366777.022509996 22705985.499782782 1.0 0.9328626564675245 1.2196601547648083 24.15009010684415 -6.8450292211641415 1.2588649377076915 0.9642728624514282 1.2300701169528618 0.9327523630286175 0.031761538166491333 0.16300917941621798 0.4996215669965451 0.019765657295620263 0.04561604624652844 1.4287978197343442e-07 6.8450292211641415 0.26579725450143366 TAVVVGTITDDVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAVVVGTITDDVR 13 0 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 160391000.0 25924000.0 104790000.0 29677000.0 False True 39328603.29826506 86089405.77199304 23811327.942108802 1.0 2.1889769417718115 0.6054455522237987 25.229075616054363 -6.70578408182209 1.8101313820940284 1.7340880798531817 0.6096006822474157 0.4450764854295569 0.5013729820191638 0.383630367877994 2.447543783368967 0.22063754064058688 0.5634287100300231 1.9688649069391328e-07 6.70578408182209 -1.1244873976057659 TAVVVGTITDDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAVVVGTITDDVR 13 0 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 86104000.0 31615000.0 25815000.0 28674000.0 False True 43303919.863250226 24674407.94121082 21901791.759567097 1.0 0.569796175938121 0.5057692658939636 25.367994287577208 -13.999999999999998 0.2682427109726963 4.289362812455614 0.48415182872190404 0.9995795635505403 0.004499792189351298 14.79756274470392 0.16393816298041014 26.515666773347053 0.02682723064091322 1.0000000000000041e-14 13.999999999999998 -3.8052109837337094 TAVVVGTITDDVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAVVVGTITDDVR 13 0 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 46027000.0 19227000.0 14479000.0 12321000.0 False True 15988102.40052183 14400998.753143527 14897264.134132605 1.0 0.9007322065108551 0.9317718739183444 23.930495382278426 -10.228941522285584 5.61573319247564 1.0000039166552712 0.9162520408972442 0.9065969118283096 0.01267189115568479 6.214223228055032e-07 8.532287938447755e-08 0.012270079658331365 0.004089835284241846 5.902805560468183e-11 10.228941522285584 -0.083751875758027 TAVVVGTITDDVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAVVVGTITDDVR 13 0 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 90707000.0 25924000.0 39909000.0 24874000.0 False True 33559129.03843704 37688029.067169495 20347187.228792872 1.0 1.123033587194811 0.6063085607939398 25.000201938146812 -6.843888268016235 1.2642484422155031 1.065454543362665 0.5879658785833587 0.9309295443722818 0.057920549969306505 0.1643065522228194 0.5084488135276484 0.035899576790465786 0.08281094847703441 1.432556409093638e-07 6.843888268016235 -0.4774886647793063 TAWLDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAWLDGK 7 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 72411000.0 15188000.0 30525000.0 26698000.0 False True 19911615.080801245 25970788.985518083 23935547.065299645 1.0 1.304303487192211 1.2020896832411285 24.24710691061205 -10.118141328993739 4.356531353655975 0.9999695258679518 1.2531965851744986 0.8910858653693614 0.04172861092828065 29098892.060035784 0.7871436192984556 10637.402926574534 0.014284813404955483 7.618310530712723e-11 10.118141328993739 0.25322705930654676 TAWLDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAWLDGK 7 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 75061000.0 33048000.0 14343000.0 27670000.0 False True 31998909.32956059 20070234.6977569 20422396.917793185 1.0 0.6272162119980764 0.6382216564777405 24.93151939646011 -9.94982977248156 5.1252852239056175 1.000001522567574 0.6327189342335366 0.9993270423758456 0.004492953909840531 1292161.0077231165 2508500.341354756 13.977889188300267 0.0015380578742885268 1.1224583306120703e-10 9.94982977248156 -0.3672825883340374 TAWLDGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAWLDGK 7 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 194487000.0 37578000.0 122860000.0 34049000.0 False True 57008573.31978886 100934673.09043874 27319200.22579315 1.0 1.7705174364607756 0.4792121366122679 25.76467556166181 -6.7450667037577015 1.6679592191824217 1.4557393850533402 0.47755765109597437 0.6275436175382525 0.3237288840117719 0.30872447833282846 1.6882247584393884 0.15342112931794116 0.3744355694189869 1.7985946458223098e-07 6.7450667037577015 -0.9781817339573659 TAWLDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAWLDGK 7 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 67483000.0 15188000.0 19803000.0 32492000.0 False True 20803414.040267143 18928037.9802362 24818058.79374531 1.0 0.9098524859236584 1.1929800919073863 24.31031697213494 -6.821048479927916 1.3672161689063922 0.951461328746091 1.1993071380782352 0.886804097263441 0.03973437231119791 0.1921206227987776 0.7053602852125963 0.022835581388533664 0.05262118646668153 1.5099115945942755e-07 6.821048479927916 0.24784580933214417 TAWLDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAWLDGK 7 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 62051100.0 33048000.0 19532000.0 9471100.0 False True 27480876.274636995 19426777.23920153 11451463.220581375 1.0 0.706919861108328 0.416706625587129 24.711924671894387 -6.992124887537438 0.22854786393571289 1.121364468567244 9.02974756129851e-12 0.9999906501203889 0.0007281192679001632 0.0737381378761819 0.007567402199423017 0.00752390906733379 0.02826037328058051 1.0182985197660468e-07 6.992124887537438 -1.1213644685582143 down TAWLDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAWLDGK 7 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 105517000.0 37578000.0 30071000.0 37868000.0 False True 48645461.77312099 28397522.41546657 30976412.55849191 1.0 0.583765090933058 0.6367790833801459 25.53580188375426 -10.113429241262423 6.405139167650465 1.0000008168523065 0.610272087157109 0.9863121984790678 0.021642871787192416 2.5245935341718465e-07 3.493092515848738e-08 0.020955664525028592 0.006985206832990866 7.70141911827968e-11 10.113429241262423 -0.38972872969519745 TAWLDGK(ub)HVVFGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAWLDGKHVVFGK 13 1 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 1 8471300.0 2208800.0 2110900.0 4151600.0 True False 2138682.853035992 2953793.378198074 3064171.4146696883 1.0 1.3811273485477207 1.4327376358396984 21.028291129304698 -12.11129260445893 0.31738318543945276 1.107627692727497e-11 1.44414693189009 0.9995365372032448 0.004154579809849333 5.625002465568806 0.17218734175414435 3.709823051673133 0.01735130682518195 7.739401824868876e-13 12.11129260445893 1.4441469318790137 TAWLDGK(ub)HVVFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAWLDGKHVVFGK 13 1 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 1 6756400.0 2208800.0 2224000.0 2323600.0 True False 1836715.0664311976 2212018.8705705623 2809454.016887468 1.0 1.2043342546694482 1.5296079768901425 20.808696404738974 -6.964250728159783 0.3706908431176347 0.9751812983881086 1.7700954447452266 0.9998968509915098 0.0022148892881956204 0.0782162045098074 0.01576239522955175 0.004282901406443694 0.0276150706750479 1.0857985862192449e-07 6.964250728159783 0.794914146357118 TAYGPNGMNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TAYGPNGMNK 10 0 P50990;P50990-2;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 13799400.0 2905600.0 6494000.0 4399800.0 False True 3809269.7378704296 5525120.513413733 3944550.901861759 1.0 1.4504408701974854 1.035513674089921 21.861083019396514 -10.502973372390784 6.832356698161934 0.9999023432168181 1.242977272143703 0.31376232528419934 0.16939331847787722 0.00025208372427423104 1.833804288374392e-05 0.16407990678195072 0.054671458451968954 3.140701251703627e-11 10.502973372390784 0.24307492892688476 TAYGPNGMNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAYGPNGMNK 10 0 P50990;P50990-2;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 10903400.0 3477300.0 2738400.0 4687700.0 False True 3366915.014877785 3831857.400567347 3459850.7420144286 1.0 1.138091512151351 1.027602635268778 21.68299587553228 -10.31461290095388 4.271855504768095 0.9999021924519554 1.082847073710721 0.4284556607684341 0.045106895106968414 4.207031634989131e-05 6.74976640271779e-06 0.04372608984907182 0.014558187795091859 4.846041165974164e-11 10.31461290095388 0.08294488125876553 TAYGPNGMNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TAYGPNGMNK 10 0 P50990;P50990-2;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 43896200.0 7620900.0 30073000.0 6202300.0 False True 11561462.462418927 24706238.188578565 4976412.686435339 1.0 2.1369474898947556 0.43043107241937606 23.462820566706615 -6.727103554856649 1.7336277018201152 1.6863994616678717 0.43194041376844367 0.5458614994255702 0.47806436335239266 0.3416940397610474 2.010487204435638 0.2186427550402988 0.5443692003087802 1.874547480419754e-07 6.727103554856649 -1.254459047899428 TAYGPNGMNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TAYGPNGMNK 10 0 P50990;P50990-2;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 11129200.0 2905600.0 4032000.0 4191600.0 False True 3979878.840887556 3853852.9079590156 3201630.408711777 1.0 0.9683342287624929 0.8044542401189728 21.924293080919405 -6.939039455176699 0.6684397034945825 1.0018735669457954 0.761482402191892 0.9980353576377003 0.003798503805945622 0.0882076128868203 0.0566257598417884 0.0036711822561302132 0.014165564923363447 1.1506958447419488e-07 6.939039455176699 -0.24039116475390343 TAYGPNGMNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAYGPNGMNK 10 0 P50990;P50990-2;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 8168700.0 3477300.0 3268100.0 1423300.0 False True 2891529.020509417 3250494.0966329407 1720905.4494043451 1.0 1.1241436878472977 0.5951541337465682 21.463401150966558 -6.844877368876587 1.2597214211952303 1.066057345794194 0.5760257099298233 0.9324888704818843 0.05868671989628929 0.16318442531853034 0.5009325553391164 0.036499354392408374 0.08422242143814894 1.4292974902626767e-07 6.844877368876587 -0.4900316358643707 TAYLPDNK(ub)EGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TAYLPDNKEGR 11 1 Q8TDB6;Q8TDB6-2 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 5112000.0 1213000.0 1766700.0 2132300.0 True False 1174493.9789626314 2472152.5232187873 1573786.662371176 1.0 2.1048660678552897 1.339969970524003 20.163607886724503 -10.186967202008509 4.871993854020088 0.9999209871412764 1.722418019191538 0.5432441765232834 0.3122675241245078 219236831.41169742 29.00298655310542 194327.191981911 0.10689747933606517 6.501787900994017e-11 10.186967202008509 0.7224970320502615 TAYLPDNK(ub)EGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TAYLPDNKEGR 11 1 Q8TDB6;Q8TDB6-2 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 5092500.0 1213000.0 2849600.0 1029900.0 True False 1008663.2450113386 2834248.6391986855 1245247.3282804303 1.0 2.809905737337366 1.2345521009506322 19.94401316215878 -6.6125661675983824 2.1435647570145253 2.207133107777766 1.2402416670023242 0.058430062533389004 0.7798067477295029 0.60581530382005 5.278332959511129 0.29997196527457476 0.8657204154267588 2.440247252125288e-07 6.6125661675983824 -0.9668914407754419 TAYLPDNKEGRK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TAYLPDNKEGRK 12 2 Q8TDB6;Q8TDB6-2 Q8TDB6 DTX3L E3 ubiquitin-protein ligase DTX3L 1 14256610.0 684010.0 1738600.0 11834000.0 True False 885464.4288528517 1641845.3816477705 9680333.427093936 1.0 1.8542194673758212 10.932492725467387 19.756074826192812 -6.925222753595197 0.785021895400774 0.8348101147665735 12.588035233530626 0.9955129554059947 0.30106124955966845 0.09519544533304233 0.09039855196805967 0.26685012724999496 0.8440301533552925 1.1878927901263658e-07 6.925222753595197 11.753225118764052 up TCAILCHIYHHALHSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCAILCHIYHHALHSR 16 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 13923300.0 3845300.0 7073600.0 3004400.0 False True 5041225.537938174 6018246.4526768355 2693533.5082398024 1.0 1.1938062297324346 0.5343013297003647 22.26534306943345 -6.828024683698249 1.3367768385506185 1.1037055685786257 0.5172671198586434 0.9018566150974094 0.08670407084889718 0.18325922024370836 0.6411664532684052 0.050937029281689944 0.11723000556259572 1.485851189579851e-07 6.828024683698249 -0.5864384487199823 TCATVTIGGINIAEALVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCATVTIGGINIAEALVSK 19 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 258086000.0 64391000.0 101680000.0 92015000.0 False True 97685854.6126597 83534409.57053399 73828194.91839285 1.0 0.8551331193422171 0.7557716028705861 26.541646332263465 -6.975131794536774 0.056026716943317234 1.575207133889368 0.03322832454116808 0.9999999733700679 1.531225190904508e-05 0.07466935526298363 0.001607692183647464 0.018419967963369595 0.02573803586483209 1.0589323241940057e-07 6.975131794536774 -1.5419788093482 TCATVTIGGINIAEALVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCATVTIGGINIAEALVSK 19 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 164422000.0 64391000.0 57540000.0 42491000.0 False True 83355418.83636796 54337848.418274894 34758073.99447763 1.0 0.6518814154715433 0.41698637568734387 26.312772654355914 -8.206486907135888 0.15865897016280603 1.3600635980444886 9.765665461374464e-11 0.9999140876743374 0.002219945157392833 0.0855229141801036 0.03206830352011122 0.11779759508711317 0.1252625908133449 6.2160298720491e-09 8.206486907135888 -1.360063597946832 down TCEEHQLCVVAVLPHILDTGAAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCEEHQLCVVAVLPHILDTGAAGR 24 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 519194000.0 135096000.0 205208000.0 178890000.0 False True 204950508.84055012 168587029.1025781 143532313.0897276 1.0 0.8225743378550843 0.7003266979024415 27.610700330924857 -7.25976867562105 0.06844046852161231 1.554637091768519 4.4723722389004164e-11 0.9999998166209508 5.236776115439788e-05 0.10270163863589457 0.0034556216231571494 0.03267328849716928 0.04495895189411114 5.498336615123293e-08 7.25976867562105 -1.5546370917237953 TCEEHQLCVVAVLPHILDTGAAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCEEHQLCVVAVLPHILDTGAAGR 24 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 432834000.0 135096000.0 144718000.0 153020000.0 False True 174884435.1402829 136664316.08265382 125171930.11778893 1.0 0.7814549989713439 0.715740826319865 27.381826653017306 -13.999999999998131 0.16838407595633811 2.0975443370749276 0.6567648502161915 0.9995168531799483 0.0026708709293990314 12.076237654062655 0.12991047922248125 4.328698310459155 0.054374709755710675 1.0000000000043029e-14 13.999999999998131 -1.440779486858736 TCEESSFCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCEESSFCK 9 0 Q14697;Q14697-3;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 19675400.0 4039200.0 8197100.0 7439100.0 False True 5295430.315668439 6974124.632045537 6669373.292886009 1.0 1.3170081025162539 1.2594582300804271 22.3363164941567 -10.070228551718232 4.541282760193212 0.9999831574057836 1.2882331662565045 0.970968643949617 0.02349463708634626 16306090.775766615 0.2516190573503781 2945.303382471415 0.008042839188190902 8.506902363265636e-11 10.070228551718232 0.28825000885072094 TCEESSFCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCEESSFCK 9 0 Q14697;Q14697-3;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 33297800.0 4945500.0 24656000.0 3696300.0 False True 7502685.064479636 20255944.161792714 2965724.684854156 1.0 2.699825993988674 0.39528844132015417 22.838975569727427 -6.709091095807587 1.7984666807172902 2.0459881207522312 0.40085245704457884 0.4607662649032399 0.7164002768069367 0.37690951611079315 2.375879896757426 0.3170645561267301 0.806375386979067 1.9539295646344636e-07 6.709091095807587 -1.6451356637076524 TCEESSFCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCEESSFCK 9 0 Q14697;Q14697-3;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 17616800.0 4039200.0 6306000.0 7271600.0 False True 5532601.395275671 6027380.068846613 5554197.843302927 1.0 1.0894296621465334 1.0039034888806009 22.399526555679593 -6.635725328310757 2.059648419911807 1.0586706879468437 1.004254302173961 0.13843217522860274 0.03830548420623451 0.5442986038486183 4.407447815607427 0.015172271634566704 0.04242531446383824 2.3135275294766668e-07 6.635725328310757 -0.05441638577288277 TCEESSFCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCEESSFCK 9 0 Q14697;Q14697-3;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 12989400.0 4945500.0 3871100.0 4172800.0 False True 6402047.240379207 3655669.882029617 3413393.216543653 1.0 0.5710157617976409 0.5331721382832956 22.610101891819877 -13.999999999999998 0.34372269261909383 6.07585357686603 0.5275008736729735 0.9997425685835174 0.0033968025908492887 20.05057991736319 0.18830065893187034 74.08429636641326 0.011539180028179481 1.0000000000000041e-14 13.999999999999998 -5.548352703193056 TCEESSFCKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCEESSFCKR 10 1 Q14697;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 4136100.0 1081900.0 1403800.0 1650400.0 False True 1418381.3771345045 1194358.5119695433 1479632.439754683 1.0 0.842057384017869 1.043183775257908 20.435814068702125 -6.697293598688069 1.8407741950472922 0.9016643142383856 1.0425513802345805 0.40466461963047884 0.06670312830328924 0.40115926701183013 2.6408174643361146 0.02893142666111704 0.07464657684663636 2.0077350526144667e-07 6.697293598688069 0.14088706599619494 TCEESSFCKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCEESSFCKR 10 1 Q14697;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 14306300.0 1872400.0 9206100.0 3227800.0 False True 2840567.6907757926 7563199.527412393 2589823.915205002 1.0 2.6625662018097493 0.9117275830514323 21.437747852160477 -6.657899854038373 1.9803529865783274 2.0720500413119645 0.9190788536654757 0.2266140822035474 0.7082472563263499 0.489514584598408 3.688247537360956 0.2891643870406988 0.7849483779881373 2.1983667458383026e-07 6.657899854038373 -1.1529711876464888 TCEESSFCKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCEESSFCKR 10 1 Q14697;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 6395600.0 1081900.0 3798200.0 1515500.0 False True 1481907.667248157 3630382.965032223 1157570.112702237 1.0 2.449803753140503 0.7811351127238568 20.499024130225017 -6.676957279138328 1.9126058986172871 1.919758997382512 0.7876009446350624 0.31042980265746456 0.6148656408860079 0.44523690770464663 3.146208246952512 0.25820775450841155 0.6836948466169912 2.1039853953048151e-07 6.676957279138328 -1.1321580527474495 TCEESSFCKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCEESSFCKR 10 1 Q14697;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 7518400.0 1872400.0 2055700.0 3590300.0 False True 2423858.7105218964 1941298.4878944682 2936902.23958893 1.0 0.8009123962000553 1.2116639583156918 21.208874174252927 -6.774911127225278 1.5556805854041282 0.886526253210674 1.2144142563420839 0.7489767564865799 0.08402884827192511 0.2585629431135294 1.2355676813089778 0.0425591679966829 0.10085803370069792 1.6791475989058564e-07 6.774911127225278 0.32788800313140987 TCFIILSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCFIILSK 8 0 O43592 O43592 XPOT Exportin-T 0 13243800.0 4156000.0 3940200.0 5147600.0 False True 5448556.246761257 3352337.518779302 4614975.731265881 1.0 0.6152707922896099 0.8470089180063297 22.377442565897173 -10.312151296370248 5.715141189571034 1.0000315046000021 0.731139855147968 0.6421823528588102 0.09460669365915735 3.798182081144645e-05 4.5712063933453465e-06 0.09161325649568954 0.0305341790818043 4.8735867803508406e-11 10.312151296370248 -0.26889164945203414 TCFSLHLDGNVLDHFSELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCFSLHLDGNVLDHFSELR 19 0 I3L2B0;A0A494C0R8;K7EIG1;O75153;I3L318 I3L2B0 CLUH Clustered mitochondria protein homolog 0 78308000.0 24400000.0 21157000.0 32751000.0 False True 37016583.87894105 17381368.04960451 26277750.49472674 1.0 0.46955624285721487 0.7098912903650275 25.141668424673494 -10.364560882303461 5.913121437155272 1.0000717212237078 0.5897237666111227 0.7953165305179372 0.0981163722836176 9.278613170217174e-05 9.971158727571507e-06 0.0950172851317897 0.031666922987061225 4.319556089488654e-11 10.364560882303461 -0.4103479546125851 TCFSLHLDGNVLDHFSELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCFSLHLDGNVLDHFSELR 19 0 I3L2B0;A0A494C0R8;K7EIG1;O75153;I3L318 I3L2B0 CLUH Clustered mitochondria protein homolog 0 48401000.0 24400000.0 11492000.0 12509000.0 False True 31586280.995905876 10852460.097720105 10232490.353178823 1.0 0.34358144598051193 0.32395362893482554 24.912794746765943 TCFVDCLIEQTHPEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCFVDCLIEQTHPEIR 16 0 Q15029-2;Q15029 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 12646400.0 1553700.0 5547000.0 5545700.0 False True 2036915.7460522016 4719409.222036649 4971884.162110733 1.0 2.316938847953557 2.440888471576141 20.9579548759576 -10.653089960890483 0.4568135961642489 7.674109354545325e-12 2.441765316674725 0.9995553178598806 0.0137488881252996 2.1673284363572427 0.21826719266391673 2.4728301559149517 0.02747409684921285 2.2228493961437512e-11 10.653089960890483 2.4417653166670505 TCFVDCLIEQTHPEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCFVDCLIEQTHPEIR 16 0 Q15029-2;Q15029 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 10588100.0 1553700.0 4642600.0 4391800.0 False True 2128144.877163748 4437474.580974839 3354547.291960201 1.0 2.08513744933043 1.5762776904695146 21.021164937480492 -10.524754609509468 5.592322404429557 0.9981730872104547 1.8307075698995041 0.7803818206100404 0.20774112664082525 0.004739705326556584 0.0004027879288565946 0.20147459079125163 0.0670481603168564 2.9870699337281265e-11 10.524754609509468 0.8325344826890494 TCFYAEQGGQIYDEGYLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCFYAEQGGQIYDEGYLVK 19 0 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 33264700.0 4546600.0 23200000.0 5518100.0 False True 6897524.600983332 19059778.73757267 4427445.116330848 1.0 2.7632781092010097 0.6418889924219564 22.717647266484942 -6.686033126092655 1.8801000930184018 2.1095220631448464 0.649470538558687 0.3520864511107299 0.7463504485381228 0.42526513463667204 2.9111555018554633 0.31791618971700336 0.832165228153562 2.0604727433840518e-07 6.686033126092655 -1.4600515245861594 TCFYAEQGGQIYDEGYLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCFYAEQGGQIYDEGYLVK 19 0 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 19634100.0 4546600.0 9172600.0 5914900.0 False True 5885663.326884655 8662136.746636566 4838448.891999146 1.0 1.4717350051385845 0.8220736768781827 22.48877358857739 -6.711960651423753 1.7882375920709535 1.2894286163293716 0.823511035468262 0.4744117787246235 0.19872645638499345 0.37114209140614385 2.3147291083945953 0.08839663674579058 0.224034886788194 1.9410617365064208e-07 6.711960651423753 -0.46591758086110957 TCHSFIINEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCHSFIINEK 10 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 26566600.0 7734300.0 10514000.0 8318300.0 False True 10139742.199067745 8945352.183251007 7457602.110767916 1.0 0.8822070628258624 0.7354824180296786 23.273517636784096 -6.9681613454359645 0.29886134866852626 1.025793770283662 0.5873056624816299 0.999964274681255 0.0006467163738957568 0.07690395266835785 0.011154390609753269 0.0024480605993158363 0.013175035860561679 1.0760653685987627e-07 6.9681613454359645 -0.43848810780203207 TCHSFIINEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TCHSFIINEK 10 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 6077900.0 2491500.0 1367100.0 2219300.0 False True 2412408.6962781493 1912990.1593323178 1637998.752427121 1.0 0.7929793000181389 0.6789889105250766 21.202042910287524 -13.999999999999964 0.07170225918452378 2.1820033094273317 0.2794067795517365 0.9999185235777363 0.0011993638441872897 12.342720235850456 0.07284003411546816 2.4156513513202533 0.3670785894576541 1.0000000000000819e-14 13.999999999999964 -1.9025965298755951 TCHSFIINEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCHSFIINEK 10 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 32705000.0 8189100.0 17746000.0 6769900.0 False True 12423463.403403116 14579087.649869159 5431826.297647417 1.0 1.173512343254906 0.437223189803859 23.56656408723616 -6.844589185994455 1.2609886884342782 1.0923224889392693 0.4107331906727231 0.9320455999189838 0.08192665493316614 0.1635098877724645 0.5030617899128456 0.0509034853869767 0.117451882120886 1.4302462376647242e-07 6.844589185994455 -0.6815892982665461 down TCHSFIINEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCHSFIINEK 10 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 20991700.0 7734300.0 5516400.0 7741000.0 False True 10593879.721598499 5272667.2077046465 5912735.2308993805 1.0 0.4977088041650014 0.5581274647516212 23.336727698306987 -10.196922946064296 5.376468475880831 1.0000227142736482 0.5279181344590639 0.987864264199052 0.024665814896901297 6.716049502122664e-06 1.0031336977433713e-06 0.023883719632866368 0.007960857526318128 6.354436643268861e-11 10.196922946064296 -0.4721045798145843 TCHSFIINEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TCHSFIINEK 10 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 8826100.0 2491500.0 2532100.0 3802500.0 False True 2071792.6421646737 2518459.074717505 4597585.169226455 1.0 1.2155941784242172 2.219133843637341 20.9824481857218 -6.941414088498871 0.6462844422473566 0.9889529851956359 2.5013891188998914 0.9983431962267222 0.02162315989670348 0.08712759939170656 0.05171808307876902 0.021281151520420056 0.08584892543477692 1.144421245168558e-07 6.941414088498871 1.5124361337042553 up TCHSFIINEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCHSFIINEK 10 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 21722800.0 8189100.0 6516700.0 7017000.0 False True 10600951.381293964 6154039.916360307 5739978.0005001 1.0 0.5805177002527803 0.5414587610154167 23.33769040932861 -13.999999999999998 0.33585266434644695 5.730849608266808 0.5350065734520602 0.9997268570313387 0.003430438553146533 19.329775622470173 0.1856478819666788 64.78810801403336 0.012249517488278076 1.0000000000000041e-14 13.999999999999998 -5.1958430348147475 TCK(ub)YCSQIGNCALYSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCKYCSQIGNCALYSR 16 1 P51530-4;P51530;F8VR31;P51530-2;P51530-3 P51530-4 DNA2 DNA replication ATP-dependent helicase/nuclease DNA2;DNA replication nuclease DNA2;DNA replication ATP-dependent helicase DNA2 1 23274600.0 3431200.0 6362400.0 13481000.0 True False 5205381.2543206 5226980.010341911 10816474.441067789 1.0 1.0041493129832484 2.077940867845143 22.311572403084078 -6.907745753016013 0.9109288994142066 0.9643362981691156 2.2102307775287002 0.9900431206894426 0.050607636189071284 0.10592842394779178 0.14698543526657265 0.04097670098273394 0.11142594971607252 1.2366712001954055e-07 6.907745753016013 1.2458944793595848 up TCK(ub)YCSQIGNCALYSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCKYCSQIGNCALYSR 16 1 P51530-4;P51530;F8VR31;P51530-2;P51530-3 P51530-4 DNA2 DNA replication ATP-dependent helicase/nuclease DNA2;DNA replication nuclease DNA2;DNA replication ATP-dependent helicase DNA2 1 20865200.0 3431200.0 2969000.0 14465000.0 True False 4441756.03906362 2803772.540039244 11832518.42343365 1.0 0.631230647379345 2.663928031924981 22.082698725176527 -6.859934803960697 1.1860575528437087 0.799955099724386 2.762241912340953 0.9535613716521478 0.1905447413653651 0.14686995375043307 0.3926277575708875 0.1253051296972046 0.29247953207480576 1.380591502654252e-07 6.859934803960697 1.962286812616567 up TCLGPK(ub)SMMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCLGPKSMMK 10 1 P49368;E9PRC8;Q5SZX6;Q5SZX9;E9PM09 P49368 CCT3 T-complex protein 1 subunit gamma 1 21028400.0 4407600.0 7760300.0 8860500.0 True False 5778406.283259111 6602493.489412473 7943700.45591757 1.0 1.1426149643615164 1.374721690811467 22.46224021355841 -6.963866335524297 0.37700871312502654 0.9835104605914926 1.5419951830124332 0.9998878252788532 0.0016355643852295461 0.07834785858204815 0.016229905766893593 0.003030609742098608 0.01964142480764533 1.0867600484523721e-07 6.963866335524297 0.5584847224209406 TCLGPK(ub)SMMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TCLGPKSMMK 10 1 P49368;E9PRC8;Q5SZX6;Q5SZX9;E9PM09 P49368 CCT3 T-complex protein 1 subunit gamma 1 28033200.0 8719700.0 7314300.0 11999200.0 True False 8442897.896422472 10234938.133570606 8856249.551716074 1.0 1.2122541642849287 1.048958504575633 23.009306836410765 -10.325462374327007 4.447503555640715 0.9998693962183379 1.1306063344309965 0.4603168029424598 0.06666517391891424 8.641836916670048e-05 1.310668124668664e-05 0.06461270895050433 0.02151609236299148 4.7264778358624955e-11 10.325462374327007 0.13073693821265853 TCLGPK(ub)SMMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCLGPKSMMK 10 1 P49368;E9PRC8;Q5SZX6;Q5SZX9;E9PM09 P49368 CCT3 T-complex protein 1 subunit gamma 1 44177500.0 9528300.0 12154300.0 22494900.0 True False 14455127.71203748 9985270.20302065 18048773.155135073 1.0 0.6907770309566643 1.248606965963019 23.785078019391715 -6.756243087371844 1.6266304364251234 0.819547273211013 1.2502729915821271 0.6754178138125734 0.12999945590982673 0.28928527795823517 1.507676117300927 0.06308444340380598 0.15216846879149926 1.7528990781246787e-07 6.756243087371844 0.4307257183711142 TCLGPK(ub)SMMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCLGPKSMMK 10 1 P49368;E9PRC8;Q5SZX6;Q5SZX9;E9PM09 P49368 CCT3 T-complex protein 1 subunit gamma 1 18470300.0 4407600.0 6678400.0 7384300.0 True False 6037208.830911329 6383326.205484498 5640280.42443228 1.0 1.0573306944098075 0.9342529937929723 22.5254502750813 -6.780047216111898 1.5357489840470882 1.032460084809474 0.9332776506706754 0.7675370292372078 0.024244812840031396 0.2505008047714207 1.1669830228491056 0.012434286326464178 0.02933777053705357 1.6594064884247214e-07 6.780047216111898 -0.09918243413879868 TCLGPK(ub)SMMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TCLGPKSMMK 10 1 P49368;E9PRC8;Q5SZX6;Q5SZX9;E9PM09 P49368 CCT3 T-complex protein 1 subunit gamma 1 23206800.0 8719700.0 12004100.0 2483000.0 True False 7250816.89820723 11939431.53067271 3002183.819905144 1.0 1.646632606820446 0.4140476669114947 22.78971211184504 -6.764152675003334 1.596819615713972 1.373653316981655 0.40859249521384183 0.7077043647047923 0.27216216582824143 0.27599142182123304 1.3878405956241973 0.1344214459488713 0.3217279328279453 1.7212633633189794e-07 6.764152675003334 -0.9650608217678132 TCLGPK(ub)SMMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCLGPKSMMK 10 1 P49368;E9PRC8;Q5SZX6;Q5SZX9;E9PM09 P49368 CCT3 T-complex protein 1 subunit gamma 1 25972900.0 9528300.0 6943400.0 9501200.0 True False 12334572.180872558 6556993.686260858 7772079.090544619 1.0 0.5315947395750705 0.6301052826620871 23.556204341484165 -9.996289691238267 5.817696647636664 1.0000006068583895 0.5808500111184882 0.9602205497261486 0.04021676080835763 3.1655602463022295e-07 5.460685361155403e-08 0.038939767783588 0.012979903737370568 1.0085798997954402e-10 9.996289691238267 -0.4191505957399013 TCLHAILNILEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCLHAILNILEK 12 0 Q92621;U3KQ47;U3KQ97 Q92621 NUP205 Nuclear pore complex protein Nup205 0 24168600.0 5339100.0 8079500.0 10750000.0 False True 8099805.040494037 6637650.099578371 8625257.78810763 1.0 0.8194826994469877 1.0648722709974687 22.94945575256867 -6.709606905306487 1.7969495131465554 0.8889757392915968 1.0642807380163943 0.46310329974300735 0.07607369114419964 0.37585300362220747 2.365616442035792 0.03369549139058594 0.08563220746049419 1.9516102693269897e-07 6.709606905306487 0.17530499872479754 TCLHAILNILEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCLHAILNILEK 12 0 Q92621;U3KQ47;U3KQ97 Q92621 NUP205 Nuclear pore complex protein Nup205 0 15924000.0 5339100.0 5606200.0 4978700.0 False True 6911570.199395138 5294210.04175413 4072627.6857759515 1.0 0.7659923706218668 0.5892478218816855 22.72058207466112 -6.974228146953775 0.11992227574004034 1.3183951574428383 0.032303998120371054 0.9999994480576385 0.000124850268868552 0.0749530175420923 0.003570945060860646 0.012461581093536862 0.02548697096479464 1.0611379655061994e-07 6.974228146953775 -1.2860911593224673 TCLHYLGEFGEDQIYEAHQQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCLHYLGEFGEDQIYEAHQQGR 22 0 Q8WU39;Q8WU39-3 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 238237900.0 50753200.0 103207400.0 84277300.0 False True 66537936.69468792 87809258.2192942 75557093.4409461 1.0 1.3196871225840776 1.1355490896515616 25.987673793935556 -10.247700923007324 4.130860772210799 0.9998258248758664 1.2276181061320843 0.6707654825791296 0.07517403722905275 0.00012308490221405453 2.2415993314959187e-05 0.07284354457124698 0.02426231617726419 5.653261527754798e-11 10.247700923007324 0.22779228125621798 TCLHYLGEFGEDQIYEAHQQGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TCLHYLGEFGEDQIYEAHQQGR 22 0 Q8WU39;Q8WU39-3 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 166861600.0 79788800.0 42386400.0 44686400.0 False True 77255948.21818106 59311510.56215599 32981691.276735578 1.0 0.7677274297980579 0.42691458764561274 26.203142679875853 -6.965620986925169 0.3472299261903569 1.0340030968950598 0.14918740069552078 0.999925379041295 0.002033075079454985 0.07775086385555134 0.014120469176475088 0.00471218500723379 0.029348425989468747 1.0823781413080557e-07 6.965620986925169 -0.884815696199539 down TCLHYLGEFGEDQIYEAHQQGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCLHYLGEFGEDQIYEAHQQGR 22 0 Q8WU39;Q8WU39-3 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 626309000.0 112031000.0 397577000.0 116701000.0 False True 169959217.56318247 326626278.06672055 93634996.19813462 1.0 1.9217920790044645 0.5509262606679496 27.340613366180488 -6.725545375497557 1.7393032572155591 1.5574739678791367 0.5523680667289134 0.5384979088035838 0.38765633804018346 0.3446923045563071 2.040670535353712 0.1767697953405488 0.4409001210874211 1.8812851375021032e-07 6.725545375497557 -1.0051059011502232 TCLHYLGEFGEDQIYEAHQQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCLHYLGEFGEDQIYEAHQQGR 22 0 Q8WU39;Q8WU39-3 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 244809800.0 50753200.0 85393600.0 108663000.0 False True 69518029.59365845 81620628.39312734 82999037.38473308 1.0 1.1740929492710033 1.1939210283990038 26.050883855458448 -13.220394035503487 0.3167143410413386 1.3727823271481043e-18 1.1981030004146358 0.9996480617763049 0.001634336414518127 10.917250874069454 0.17728506893242063 7.0904525919738255 0.006689915558723717 6.020131315320063e-14 13.220394035503487 1.1981030004146358 TCLHYLGEFGEDQIYEAHQQGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TCLHYLGEFGEDQIYEAHQQGR 22 0 Q8WU39;Q8WU39-3 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 142228000.0 79788800.0 24406800.0 38032400.0 False True 66347922.443166286 24275315.724029504 45984798.99805091 1.0 0.365879063429963 0.6930857411163334 25.98354795531013 -10.59509748117384 6.6057026613170935 1.0009951996734359 0.5294824022732508 0.733834409139078 0.13358156679382094 0.0019615324125619674 0.00012023388360691492 0.12958359412913215 0.04311326529606351 2.5404024261293315e-11 10.59509748117384 -0.47151279740018504 TCLHYLGEFGEDQIYEAHQQGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCLHYLGEFGEDQIYEAHQQGR 22 0 Q8WU39;Q8WU39-3 Q8WU39 MZB1 Marginal zone B- and B1-cell-specific protein 0 335305000.0 112031000.0 107088000.0 116186000.0 False True 145026337.96116138 101128458.66208234 95041340.16903302 1.0 0.6973109856029388 0.6553384819968733 27.111739688272937 -13.999999999999998 0.2783554988873309 3.4446809484633625 0.6424968098638485 0.9996015432201819 0.0030648876376306983 15.309922502545849 0.16710656405041932 21.285914747661515 0.016733798844526335 1.0000000000000041e-14 13.999999999999998 -2.802184138599514 TCLLISYTTNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCLLISYTTNK 11 0 P60953;A0A590UJK8;P60953-1;Q5JYX0;A0A494C1M1;A0A494BZX6;A0A3B3IRV0 P60953 CDC42 Cell division control protein 42 homolog 0 17804100.0 5047400.0 7425600.0 5331100.0 False True 6617190.279091133 6317729.424762097 4779488.911522174 1.0 0.954745013865588 0.7222837352319018 22.65778733456034 -6.939205420083497 0.6669155674314962 1.0026485176359303 0.6610351516137758 0.9980579449049894 0.005361445464164803 0.08813105200036166 0.05627470913157159 0.005188058946274025 0.02007854747180425 1.1502561922692208e-07 6.939205420083497 -0.34161336602215453 TCLLISYTTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCLLISYTTNK 11 0 P60953;A0A590UJK8;P60953-1;Q5JYX0;A0A494C1M1;A0A494BZX6;A0A3B3IRV0 P60953 CDC42 Cell division control protein 42 homolog 0 14483900.0 5047400.0 4392400.0 5044100.0 False True 6913560.180856222 4198329.244275595 3852787.4665003954 1.0 0.6072600996373544 0.5572798045743257 22.72099739608323 -13.999999999999998 0.2906652722040435 4.396947877289022 0.543751068453256 0.9996289508029741 0.0038134996356066794 16.00527613478534 0.17098290721477732 32.52301146705116 0.018819609925548465 1.0000000000000041e-14 13.999999999999998 -3.853196808835766 TCLLIVFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCLLIVFSK 9 0 P61586;Q5JR07;C9JNR4;E9PQH6;C9JX21;Q5JR08;Q5JR05;P08134;E9PLA2;C9JRM1;Q5JR06;E9PN11;U3KQA9;U3KQV3;P62745 P61586 RHOA;RHOC;RHOB Transforming protein RhoA;Rho-related GTP-binding protein RhoC;Rho-related GTP-binding protein RhoB 0 22370200.0 6142800.0 8078200.0 8149200.0 False True 8053270.286959825 6872964.048576967 7305998.956646176 1.0 0.8534376475238814 0.9072089593809287 22.941143323818135 -10.514011051874283 8.331814931216536 1.0000106866015417 0.8803233039100892 0.8685033023935143 0.021952046141638815 4.35809109005213e-06 2.5418656017817316e-07 0.02125687451015245 0.007084992426812001 3.0618855142011206e-11 10.514011051874283 -0.11968738269145252 TCLLIVFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCLLIVFSK 9 0 P61586;Q5JR07;C9JNR4;E9PQH6;C9JX21;Q5JR08;Q5JR05;P08134;E9PLA2;C9JRM1;Q5JR06;E9PN11;U3KQA9;U3KQV3;P62745 P61586 RHOA;RHOC;RHOB Transforming protein RhoA;Rho-related GTP-binding protein RhoC;Rho-related GTP-binding protein RhoB 0 98427000.0 27367000.0 31045000.0 40015000.0 False True 41517739.795695946 25504777.194307867 32106017.710802466 1.0 0.6143103482948243 0.7733084187335946 25.30722457047243 -10.13768362856826 5.224376491731702 1.000009570320847 0.6938093835139664 0.8317825564427072 0.06491069044452975 7.23592655840067e-06 1.1943160713498158e-06 0.06285146886520009 0.02094983525675179 7.283101650033162e-11 10.13768362856826 -0.30620018680688055 TCLLIVFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCLLIVFSK 9 0 P61586;Q5JR07;C9JNR4;E9PQH6;C9JX21;Q5JR08;Q5JR05;P08134;E9PLA2;C9JRM1;Q5JR06;E9PN11;U3KQA9;U3KQV3;P62745 P61586 RHOA;RHOC;RHOB Transforming protein RhoA;Rho-related GTP-binding protein RhoC;Rho-related GTP-binding protein RhoB 0 30236800.0 6142800.0 9636000.0 14458000.0 False True 8413959.162928162 9210249.658009207 11043318.171856767 1.0 1.0946392155775482 1.3124996161751699 23.004353385341027 -6.957204710716148 0.4731890865499108 0.994420469920861 1.421697648664256 0.9996520533566406 0.002440624658966389 0.08071523773346362 0.024938879762278935 0.003030622088962527 0.01797744230919014 1.1035583197953664e-07 6.957204710716148 0.4272771787433951 TCLLIVFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCLLIVFSK 9 0 P61586;Q5JR07;C9JNR4;E9PQH6;C9JX21;Q5JR08;Q5JR05;P08134;E9PLA2;C9JRM1;Q5JR06;E9PN11;U3KQA9;U3KQV3;P62745 P61586 RHOA;RHOC;RHOB Transforming protein RhoA;Rho-related GTP-binding protein RhoC;Rho-related GTP-binding protein RhoB 0 78744000.0 27367000.0 21421000.0 29956000.0 False True 35427120.98421956 20228902.519427646 24504315.374516312 1.0 0.5710004639789467 0.6916823804404362 25.07835089256488 -10.379533447800567 8.690820098804314 1.0000014936923642 0.6313414222096948 0.9256083418229134 0.04926818608530582 1.4258660389749606e-06 1.0183203496786065e-07 0.04770390864710398 0.015901238683853125 4.173174569365178e-11 10.379533447800567 -0.36866007148266944 TCNCETEDYGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCNCETEDYGEK 12 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 11445900.0 1197500.0 5137000.0 5111400.0 False True 1569934.096606497 4370579.623869168 4582521.3600109555 1.0 2.783925537585576 2.9189259408508543 20.582272567616503 -10.457756351229078 0.5181983021766638 1.1455210712940604e-19 2.911674161247105 0.9996339549174917 0.016731369549406818 1.8498462950404642 0.24656890484723581 2.5284647228418833 0.026511009236942662 3.485327947719616e-11 10.457756351229078 2.911674161247105 TCNCETEDYGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCNCETEDYGEK 12 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 7515700.0 1197500.0 3588100.0 2730100.0 False True 1640248.1112206932 3429565.8777400213 2085306.6081744486 1.0 2.090882381926778 1.2713360825774933 20.645482629139394 -10.139376956327053 4.462376615642049 0.9999270719067279 1.6811092316760248 0.4794180534645909 0.3345783760662503 233803456.00002566 46.04817657613946 236270.94670812218 0.11453507732740621 7.254759897661169e-11 10.139376956327053 0.6811821597692969 TCNTMNQFVNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCNTMNQFVNK 11 0 Q7L5N1;E7EM64 Q7L5N1 COPS6 COP9 signalosome complex subunit 6 0 3729480.0 761180.0 1344500.0 1623800.0 False True 1042608.8161160465 1285095.5443330614 1240291.8832107484 1.0 1.232576901776385 1.1896042542888867 19.99176653359683 -10.127265434250804 4.607992162068473 0.9999799130661623 1.2110905780366132 0.9698550433947166 0.017543509887060927 3.6206470550337943e-06 6.857132034909905e-07 0.016988045919363242 0.005662143466968029 7.459926795521378e-11 10.127265434250804 0.21111066497045095 TCNVLVALEQQSPDIAQGVHLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCNVLVALEQQSPDIAQGVHLDR 23 0 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 6742100.0 2154900.0 3335800.0 1251400.0 False True 2825094.768081282 2838111.6428465545 1121917.1322764251 1.0 1.004607588712542 0.39712548582517004 21.42986783301048 -6.9051909493551635 0.9278712869796725 1.0217872784117492 0.32618943422178487 0.9889764891931876 0.029953425421211766 0.10768445448157188 0.15665624484566942 0.02395449002590753 0.06411587040673572 1.2439675474224476e-07 6.9051909493551635 -0.6955978441899644 down TCNVLVALEQQSPDIAQGVHLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TCNVLVALEQQSPDIAQGVHLDR 23 0 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 17831900.0 6243800.0 5658200.0 5929900.0 False True 6045593.986683331 7917548.7671231935 4376681.296813219 1.0 1.309639513431307 0.7239456216301926 22.527452662238318 -6.7630679338728505 1.600931906942306 1.1791677385390498 0.721475614971563 0.7033704779775483 0.130298714126429 0.2777891898882095 1.4038715854641264 0.06419656920886373 0.15381015915253388 1.7255679514601985e-07 6.7630679338728505 -0.4576921235674868 TCPICK(ub)QPVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCPICKQPVHR 11 1 I3L0L6;Q9H6Y7 I3L0L6 RNF167 E3 ubiquitin-protein ligase RNF167 1 9406700.0 3249600.0 3327200.0 2829900.0 True False 4260257.06917116 2830794.7293240237 2537089.094317608 1.0 0.664465707904983 0.5955248833871902 22.02250905640175 -13.999999999999998 0.22244330241564217 3.0467190246789504 0.5595006719412333 0.9995004577342792 0.003948828451021262 13.06720169771812 0.14939229538010354 11.763435192004913 0.037547895176561125 1.0000000000000041e-14 13.999999999999998 -2.487218352737717 TCPICK(ub)QPVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCPICKQPVHR 11 1 I3L0L6;Q9H6Y7 I3L0L6 RNF167 E3 ubiquitin-protein ligase RNF167 1 7264100.0 3249600.0 2158900.0 1855600.0 True False 4451064.9371380005 2063512.6594724027 1417345.4972816021 1.0 0.46359976513827833 0.3184284024831469 22.08571911792464 -13.999999999999998 0.18342000353615476 3.8131109871416147 0.20709326976402484 0.9994944102919903 0.006591175356549694 12.250912358181807 0.13579222813497902 12.292603899596719 0.10532016803502409 1.0000000000000041e-14 13.999999999999998 -3.60601771737759 TCPLLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCPLLLR 7 0 O00422;O00422-2;U3KPY7;U3KQ12 O00422 SAP18 Histone deacetylase complex subunit SAP18 0 9274000.0 2004600.0 2196900.0 5072500.0 False True 2628050.0125740143 1869131.083449128 4547646.358855815 1.0 0.7112235591051133 1.7304261095098694 21.325561300161723 -6.831006993822143 1.3233295979831956 0.845798928245798 1.7584349478240258 0.9078860507181433 0.1301759312542023 0.17957280759575261 0.6146501565120532 0.0772264686283693 0.1777231543025684 1.4756827688801744e-07 6.831006993822143 0.9126360195782277 TCPLLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TCPLLLR 7 0 O00422;O00422-2;U3KPY7;U3KQ12 O00422 SAP18 Histone deacetylase complex subunit SAP18 0 6055600.0 2838400.0 1135700.0 2081500.0 False True 2748296.5456616054 1589190.9325972614 1536292.7063385078 1.0 0.5782457992409589 0.5589981578820752 21.39010625101769 TCPLLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCPLLLR 7 0 O00422;O00422-2;U3KPY7;U3KQ12 O00422 SAP18 Histone deacetylase complex subunit SAP18 0 7744900.0 2004600.0 2944700.0 2795600.0 False True 2745754.792278079 2814593.4171792963 2135336.8571892926 1.0 1.0250709295290363 0.7776866540284397 21.388771361684615 -6.881937418883208 1.0689840009511054 1.0159730954696482 0.7594935715894797 0.9752128468946075 0.01750425093269807 0.1259255575127055 0.26205940990900506 0.012591429101612513 0.030603573832186596 1.3123889984792305e-07 6.881937418883208 -0.2564795238801685 TCPLLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TCPLLLR 7 0 O00422;O00422-2;U3KPY7;U3KQ12 O00422 SAP18 Histone deacetylase complex subunit SAP18 0 5721200.0 2838400.0 1298800.0 1584000.0 False True 2360255.362440378 1291803.1066083843 1915207.0764114966 1.0 0.5473149758137733 0.8114406207433736 21.170511526451968 -10.2271466073031 5.665499465820262 1.0000134088986627 0.6793777982785649 0.6627021355447857 0.10782884301020618 1.8263528345734125e-05 2.4913907114703496e-06 0.10440919062821795 0.03480160943494061 5.927252011250807e-11 10.2271466073031 -0.3206356106200978 TCQVLEALNVLVNRPNIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCQVLEALNVLVNRPNIR 18 1 O14933;E9PQT7;E9PKW8;O14933-2 O14933 UBE2L6 Ubiquitin/ISG15-conjugating enzyme E2 L6 0 5286100.0 1978200.0 1937800.0 1370100.0 False True 2593439.3569160523 1648687.7934852405 1228335.194927223 1.0 0.6357148043923232 0.47363173989457713 21.30643520449714 -13.999999999990626 0.10966587375118719 2.758749932414156 0.17486112165534892 0.9997447596003403 0.00351653643587384 12.01458246366921 0.10043513499090584 4.681614593567246 0.26539206912748253 1.000000000021584e-14 13.999999999990626 -2.583888810758807 TCQVLEALNVLVNRPNIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TCQVLEALNVLVNRPNIR 18 1 O14933;E9PQT7;E9PKW8;O14933-2 O14933 UBE2L6 Ubiquitin/ISG15-conjugating enzyme E2 L6 0 25875500.0 14179000.0 8341900.0 3354600.0 False True 13728895.4061922 11672864.172433801 2475929.6241571745 1.0 0.8502405930756047 0.18034441598560405 23.71071221860294 -6.961908384758009 0.6483915470998072 1.0064571430612281 2.5384105047721037e-23 0.9984583105508968 0.013992806921412493 0.08292538775695052 0.05040268759550185 0.013911530217110755 0.05431144680536585 1.0916706021377357e-07 6.961908384758009 -1.0064571430612281 down TCQVLEALNVLVNRPNIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCQVLEALNVLVNRPNIR 18 1 O14933;E9PQT7;E9PKW8;O14933-2 O14933 UBE2L6 Ubiquitin/ISG15-conjugating enzyme E2 L6 0 43616900.0 12507000.0 21143000.0 9966900.0 False True 18974033.38417688 17369866.45898701 7996937.846352534 1.0 0.9154546167011784 0.4214674700120147 24.17752305486543 -6.936399084963676 0.692251677167463 1.006038634555909 0.30127415850334555 0.9976531998057042 0.01235998084440513 0.08944846559084145 0.062382268450498324 0.011725502072758852 0.043233830637824246 1.1577130133549763e-07 6.936399084963676 -0.7047644760525633 down TCQVLEALNVLVNRPNIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCQVLEALNVLVNRPNIR 18 1 O14933;E9PQT7;E9PKW8;O14933-2 O14933 UBE2L6 Ubiquitin/ISG15-conjugating enzyme E2 L6 0 13702700.0 1978200.0 1923700.0 9800800.0 False True 2709593.998844906 1838704.5731747919 7486052.893811992 1.0 0.6785904360426792 2.7627950523227023 21.369645266020033 -6.867533338514498 1.1469930339528438 0.820652920257099 2.8793045534794883 0.9621625455308802 0.17821618591220598 0.13924576656676618 0.343914687114075 0.120751595108868 0.284737319746482 1.356646383659644e-07 6.867533338514498 2.0586516332223894 up TCQVLEALNVLVNRPNIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TCQVLEALNVLVNRPNIR 18 1 O14933;E9PQT7;E9PKW8;O14933-2 O14933 UBE2L6 Ubiquitin/ISG15-conjugating enzyme E2 L6 0 24693400.0 14179000.0 2756900.0 7757500.0 False True 11790466.736204252 2742048.0324981925 9379557.383372596 1.0 0.23256484190556737 0.7955204482763497 23.491117494037216 -10.140964028362717 7.075156451386692 1.0000004062414751 0.5140426450948861 0.49838057353586895 0.22982566390791942 1.472569916201415e-06 1.7903268061809608e-07 0.22252792789342726 0.07417591407053623 7.22829671482274e-11 10.140964028362717 -0.48595776114658906 TCQVLEALNVLVNRPNIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCQVLEALNVLVNRPNIR 18 1 O14933;E9PQT7;E9PKW8;O14933-2 O14933 UBE2L6 Ubiquitin/ISG15-conjugating enzyme E2 L6 0 33701800.0 12507000.0 11482000.0 9712800.0 False True 16190558.049827661 10843016.606510822 7945170.061743964 1.0 0.669712345500422 0.4907286109158255 23.948649376957878 -12.23922127328543 0.0900702048268145 2.292587499578231 7.2426280073918e-20 0.9998903481333231 0.0022089049401199153 6.2957746833842325 0.0691738828173807 1.9140561874729196 0.3732548824958609 5.764726754001849e-13 12.23922127328543 -2.292587499578231 TCSDDVVDYFK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TCSDDVVDYFKR 12 1 Q96P11-2;Q96P11;Q96P11-4;Q96P11-5;Q96P11-3 Q96P11-2 NSUN5 Probable 28S rRNA (cytosine-C(5))-methyltransferase 1 3906230.0 968470.0 908860.0 2028900.0 True False 937726.4499636763 1271772.5376422887 1497470.2243046847 1.0 1.35622978075488 1.5969158429547237 19.838807600974857 -7.941915546976056 0.07745084678683971 4.0104171433326635e-15 2.7254981411340986 0.9999968062088996 0.0004381757136440327 0.11864212739006094 0.012047063421198314 0.19375904760729093 0.21824251072979034 1.143100600834151e-08 7.941915546976056 2.7254981411340946 TCSDDVVDYFK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TCSDDVVDYFKR 12 1 Q96P11-2;Q96P11;Q96P11-4;Q96P11-5;Q96P11-3 Q96P11-2 NSUN5 Probable 28S rRNA (cytosine-C(5))-methyltransferase 1 7392270.0 968470.0 1187200.0 5236600.0 True False 805325.7154955736 1180804.3179592518 6331548.848697251 1.0 1.466244396818522 7.862096946452285 19.619212876409133 -6.921554328512552 0.8131144184438303 0.8666293448519056 8.931288109117837 0.9946019123329581 0.2300192803090506 0.09726590946925273 0.10093804776898356 0.19983382189449947 0.6077896835383048 1.1979692526267925e-07 6.921554328512552 8.064658764265932 up TCSDDVVDYFK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCSDDVVDYFKR 12 1 Q96P11-2;Q96P11;Q96P11-4;Q96P11-5;Q96P11-3 Q96P11-2 NSUN5 Probable 28S rRNA (cytosine-C(5))-methyltransferase 1 22738700.0 2614800.0 2588900.0 17535000.0 True False 3384910.145413721 2444825.4391739983 14343809.924293732 1.0 0.7222718873310533 4.237574797584637 21.690686106378035 -6.887793069145204 1.035338139162658 0.8009984254749526 4.5271780139836775 0.979447522025774 0.2287619709852232 0.12095369700040658 0.23245009749658543 0.16882093050054095 0.4176689528143751 1.2948126415138173e-07 6.887793069145204 3.726179588508725 up TCSNVNWAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCSNVNWAR 9 0 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 0 5739100.0 1607600.0 2342300.0 1789200.0 False True 2107579.1680205464 1992837.9702138887 1604070.7472182969 1.0 0.9455578231424523 0.7610963192072409 21.007155394164343 -6.948688200120015 0.5730679243220912 1.0022670936423346 0.6953713432457181 0.99909424683179 0.0030767829703293678 0.08401688618844654 0.03817619571086765 0.003248371797256713 0.015381023662404928 1.125412669240772e-07 6.948688200120015 -0.30689575039661643 TCSNVNWAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCSNVNWAR 9 0 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 0 20449200.0 4985000.0 12195000.0 3269200.0 False True 7562609.452316441 10018706.970030097 2623041.187058739 1.0 1.3247685250970285 0.34684340155305743 22.85045268662144 -6.817187512386494 1.384014694539065 1.1755606093160327 0.32675748630213247 0.8777905889936213 0.14216564123711914 0.1971602581658255 0.7428303767351518 0.0807355669969002 0.18623503704603214 1.5233948659000023e-07 6.817187512386494 -0.8488031230139002 down TCSNVNWAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCSNVNWAR 9 0 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 0 5483300.0 1607600.0 1759600.0 2116100.0 False True 2201973.163756481 1681855.0537809231 1616320.762447509 1.0 0.7637945282274665 0.7340329069633748 21.070365455687234 -13.999999999999998 0.29209717634458754 3.0596237974678537 0.7260927785386984 0.9996321549537796 0.0022820437476921405 16.091444108807973 0.1714354667284027 19.93964348554387 0.011134707874689039 1.0000000000000041e-14 13.999999999999998 -2.3335310189291554 TCSNVNWAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCSNVNWAR 9 0 O95218-2;O95218 O95218-2 ZRANB2 Zinc finger Ran-binding domain-containing protein 2 0 13550000.0 4985000.0 4161600.0 4403400.0 False True 6453180.769040607 3930003.3016595957 3602026.3826994644 1.0 0.6090025124530749 0.5581784412394474 22.62157900871389 -13.999999999999998 0.287622336812298 4.324491344025353 0.5439939089687245 0.9996221435901107 0.00383698387128891 15.825802428925552 0.17002194723370928 31.087598593198855 0.019403300584481607 1.0000000000000041e-14 13.999999999999998 -3.7804974350566285 TCSVCITEYTEGNK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCSVCITEYTEGNKLR 16 1 Q9NVW2;Q9NVW2-2 Q9NVW2 RLIM E3 ubiquitin-protein ligase RLIM 1 11455000.0 3872100.0 4541800.0 3041100.0 True False 5076360.597469736 3864181.1437977348 2726436.144291058 1.0 0.7612109245595751 0.5370848055297774 22.275363123472392 -6.971890234160266 0.20814494874324357 1.1201560756290894 0.1718958903830531 0.9999936125162585 0.0004776740023881337 0.07569401209856831 0.0067895574314979735 0.006811464498256715 0.023325621082192383 1.0668657323356341e-07 6.971890234160266 -0.9482601852460363 TCSVCITEYTEGNK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCSVCITEYTEGNKLR 16 1 Q9NVW2;Q9NVW2-2 Q9NVW2 RLIM E3 ubiquitin-protein ligase RLIM 1 12749800.0 3872100.0 5997000.0 2880700.0 True False 5303720.009567965 5732032.7105729785 2200337.989878806 1.0 1.0807570347288946 0.4148669209365075 22.338573184995283 -6.876584199969446 1.0987146461187525 1.0481068379301972 0.3706686849241766 0.9708222165372441 0.05068191602080703 0.1306967631500143 0.29096050662729467 0.03563713021125243 0.08547680081590554 1.3286659335986793e-07 6.876584199969446 -0.6774381530060206 down TCTDIKPEWLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCTDIKPEWLVK 12 1 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 15574700.0 2142500.0 9599200.0 3833000.0 False True 3250329.137730788 7886147.7611080725 3075405.8699364187 1.0 2.4262612882994903 0.9461829062897638 21.632154386335745 -6.654572419134324 1.9919963968690144 1.9221180835459728 0.9523680429151993 0.21290318943267494 0.608061418103885 0.4974117061168261 3.788213812732934 0.24710903452373187 0.6738009334195517 2.2152746657609706e-07 6.654572419134324 -0.9697500406307735 TCTDIKPEWLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCTDIKPEWLVK 12 1 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 7869700.0 2142500.0 3291200.0 2436000.0 False True 2773508.4849888673 3108041.8268026845 1992672.9954707457 1.0 1.1206173853890913 0.7184665221886798 21.403280708428195 -6.826308372410067 1.3444290445853515 1.064631151877478 0.7084461815560193 0.898267001599439 0.053744600121522546 0.1854114381860119 0.6567261782838998 0.031399553793750645 0.07227613982721495 1.4917348215901845e-07 6.826308372410067 -0.3561849703214587 TCTFILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCTFILR 7 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 81527000.0 22879000.0 23361000.0 35287000.0 False True 29994590.560551133 19875629.860464767 31635839.736805353 1.0 0.662640479133767 1.0547181723631458 24.838199002427537 -6.678980126738368 1.905250012819531 0.7863581368935801 1.0532239537421626 0.3195872632727955 0.14301218225985415 0.4407870064638992 3.0925731374975265 0.060246614572460784 0.15911952668572013 2.094208284369699e-07 6.678980126738368 0.26686581684858246 TCTFILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TCTFILR 7 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 27565700.0 12928000.0 5402400.0 9235300.0 False True 12517607.716429414 7559606.493143816 6816297.876938758 1.0 0.6039178303392428 0.5445367862097434 23.577455534355785 -13.999999999999998 0.26719937869826427 4.011656072988822 0.5242848249748865 0.9995773419462609 0.0041563355569436775 14.747615859458898 0.16361180149184626 24.08592965115693 0.025012278199168795 1.0000000000000041e-14 13.999999999999998 -3.487371248013936 TCTFILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCTFILR 7 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 139436000.0 35277000.0 76369000.0 27790000.0 False True 53517788.094155975 62740355.2762796 22297294.31921028 1.0 1.1723271366503039 0.4166333309587041 25.67351515441483 -6.846739674204822 1.2506021471430018 1.0917707332327853 0.3882527643968445 0.9354366143884733 0.08216496041055642 0.161085448453637 0.48644039589758054 0.051448466930260686 0.11884140907363656 1.4231816182865373e-07 6.846739674204822 -0.7035179688359408 down TCTFILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCTFILR 7 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 67220000.0 22879000.0 20201000.0 24140000.0 False True 31337984.581727076 19308453.024226237 18438629.17890596 1.0 0.6161357624601309 0.5883795472175124 24.901409063950428 -13.999999999999998 0.37283923480451503 6.443322553088792 0.5856291905890013 0.9997957203783986 0.0026847184959949036 23.155760485682226 0.19845698998419212 100.86384506669015 0.007689255198353328 1.0000000000000041e-14 13.999999999999998 -5.8576933624997904 TCTFILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TCTFILR 7 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 29302400.0 12928000.0 7333200.0 9041200.0 False True 10750204.807507476 7293694.596073771 10931673.118214414 1.0 0.6784702921176136 1.0168804514849994 23.35786080979006 -11.038989019199944 12.089957185663685 1.4509679724729245 0.8476753718013043 0.21268649161366726 0.1381553690373387 0.043216946131673574 0.0001393709000828367 0.0034424561410070866 0.044589453622562725 9.141363544087063e-12 11.038989019199944 -0.6032926006716203 TCTFILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCTFILR 7 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 105690000.0 35277000.0 38382000.0 32031000.0 False True 45666771.91363007 36246007.95951039 26201686.66581425 1.0 0.7937063742552848 0.5737582396971196 25.44464147650728 -6.9703112572999055 0.25063996499685226 1.0692540075922865 0.2917633669857234 0.9999847086866337 0.0006805521429150371 0.0762018112299363 0.008668001213925686 0.004884461840412681 0.021057960689706823 1.0707516263180425e-07 6.9703112572999055 -0.7774906406065631 TCTTVAFTQVNSEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCTTVAFTQVNSEDK 15 0 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 57047000.0 14708000.0 18797000.0 23542000.0 False True 19282330.432474624 15992560.870132135 21106099.670809947 1.0 0.8293894208553768 1.0945824076981792 24.200776088196257 -6.732980050160786 1.7123614743038962 0.8976700340441097 1.0945127208059546 0.5730359511844711 0.07170529379258529 0.3306752703890818 1.9008475536115932 0.03316635491086055 0.08202395340994184 1.84935356930675e-07 6.732980050160786 0.1968426867618449 TCTTVAFTQVNSEDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TCTTVAFTQVNSEDK 15 0 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 15919500.0 6973900.0 4127200.0 4818400.0 False True 6752517.361819857 5775212.4830636745 3556316.491098468 1.0 0.8552680687232189 0.5266652865206426 22.686994013466666 -6.957491071150951 0.46945810492708767 1.0087251648619682 0.3597493582677679 0.999665531793098 0.0036218151293111217 0.08060983161079782 0.024537301783577565 0.004538856881638737 0.027122459998463425 1.1028309071965168e-07 6.957491071150951 -0.6489758065942003 TCTTVAFTQVNSEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCTTVAFTQVNSEDK 15 0 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 39603000.0 14708000.0 12829000.0 12066000.0 False True 20145945.06875487 12262172.36017021 9216259.307070393 1.0 0.6086670205007205 0.45747465684120464 24.26398614971915 -13.999999999982757 0.1316411200711796 2.860305210105658 0.25008783899536297 0.999638250784546 0.004347959840164826 11.93456055855318 0.11298879606710471 5.736424529907999 0.1845556376755943 1.0000000000397037e-14 13.999999999982757 -2.610217371110295 TCTTVAFTQVNSEDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TCTTVAFTQVNSEDK 15 0 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 12947600.0 6973900.0 1609800.0 4363900.0 False True 5799106.846153806 1601127.687879719 5276371.313606139 1.0 0.276099014961528 0.9098593030934815 22.467399288900943 -10.630991539232468 9.272634803745346 1.0001541473102713 0.5929791590276604 0.3548172540376002 0.25873155419375526 0.0008248031337202598 3.2823073084680364e-05 0.25060791317209696 0.0835052500442313 2.338882803481731e-11 10.630991539232468 -0.4071749882826109 TCTTVAFTQVNSEDK(ub)GALAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCTTVAFTQVNSEDKGALAK 20 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 20647500.0 3637900.0 6132600.0 10877000.0 True False 4769322.129473715 5217639.984687573 9751552.379551439 1.0 1.0940003302446943 2.044641170133648 22.185352797831104 -6.926011326940144 0.7788244142850564 0.983209375444333 2.221362861213783 0.9956949515482908 0.03095979773276021 0.09476168263302445 0.08821453987444339 0.027563561191846324 0.08797772552236985 1.1857378222469695e-07 6.926011326940144 1.23815348576945 up TCTTVAFTQVNSEDK(ub)GALAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCTTVAFTQVNSEDKGALAK 20 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 64360400.0 9154400.0 13073000.0 42133000.0 True False 13887894.076285986 10740021.010184797 33805394.08245011 1.0 0.7733369041548004 2.4341627245108297 23.727324513635967 -6.872430381115984 1.121100695993251 0.8697028552692674 2.536054391178188 0.9670520470477776 0.1334759957639716 0.13454887509677987 0.3145785112684057 0.09225196278536926 0.21938997955533227 1.3414349547609428e-07 6.872430381115984 1.6663515359089207 up TCTTVAFTQVNSEDK(ub)GALAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCTTVAFTQVNSEDKGALAK 20 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 21680300.0 3637900.0 4539400.0 13503000.0 True False 4982929.940550947 4338834.298211594 10313869.503014376 1.0 0.8707395749039697 2.069840360202617 22.248562859353996 -6.880216354846805 1.078645877602269 0.91966615434248 2.1551549132366623 0.9738572048266974 0.08688944636245989 0.12743611670386884 0.27115902062536373 0.06204295406081075 0.15011173995910357 1.3176001789734958e-07 6.880216354846805 1.2354887588941823 up TCTTVAFTQVNSEDK(ub)GALAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCTTVAFTQVNSEDKGALAK 20 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 74108400.0 9154400.0 12674000.0 52280000.0 True False 11850551.260201676 11968680.758658607 42765576.43809965 1.0 1.0099682703245756 3.608741525950908 23.498450835728416 -6.907742064292584 0.910983830944527 0.9136785652921072 3.9288497312959954 0.9900409559556869 0.12249136431638696 0.10592992043147274 0.14701064115086987 0.099178865400422 0.269675747241462 1.2366817040299993e-07 6.907742064292584 3.015171166003888 up TCTTVAFTQVNSEDKGALAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCTTVAFTQVNSEDKGALAK 20 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 65618000.0 18773000.0 19197000.0 27648000.0 False True 24611584.797990583 16332882.42931992 24787250.178343106 1.0 0.6636257909995874 1.0071375078766511 24.552834223534937 -10.903588654060988 11.01957963695632 1.0142582341140018 0.8353816494381192 0.23442332050313153 0.1402380711693678 0.04721765943663875 0.0004131110820980091 0.1305140432121456 0.04526164284526765 1.248565544495825e-11 10.903588654060988 -0.17887658467588263 TCTTVAFTQVNSEDKGALAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TCTTVAFTQVNSEDKGALAK 20 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 20064200.0 10486000.0 4396600.0 5181600.0 False True 10153127.669746207 6152185.307966111 3824383.515332031 1.0 0.6059399140915062 0.37667048418269594 23.275420882120347 -9.224684965838513 0.1499692037875331 1.5412145861793092 1.1562036701961144e-10 0.9998200929581106 0.003452760770641708 0.6658252395012144 0.05326124489043777 0.33674441478867984 0.17826776540647035 5.960943894119691e-10 9.224684965838513 -1.5412145860636888 TCTTVAFTQVNSEDKGALAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCTTVAFTQVNSEDKGALAK 20 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 62093000.0 18773000.0 18533000.0 24787000.0 False True 25713885.421249293 17714150.779564608 18932821.10428925 1.0 0.6888943654126299 0.7362878380349184 24.61604428505783 -10.187682749076593 5.31530601140485 1.0000138288301614 0.7125911017237578 0.9800138041689082 0.019348304177471357 3.170883476181357e-06 4.846175583804829e-07 0.01873481570680498 0.006244638321351953 6.4910843232256e-11 10.187682749076593 -0.2874227271064036 TCTTVAFTQVNSEDKGALAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TCTTVAFTQVNSEDKGALAK 20 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 18136300.0 10486000.0 3175100.0 4475200.0 False True 8719573.608564628 3157995.1060919967 5410943.629013081 1.0 0.36217311165194116 0.6205514021578176 23.055826157554623 -10.337630863041442 5.806861874650179 1.0000724640320107 0.4913622569049279 0.8378482920994832 0.10548249539200494 9.897089123889107e-05 1.128917405898393e-05 0.10214744035015301 0.03404432899746882 4.595884829514263e-11 10.337630863041442 -0.5087102071270828 TCTTVAFTQVNSEDKGALAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCTTVAFTQVNSEDKGALAK 20 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 67097000.0 24038000.0 23005000.0 20054000.0 False True 31117664.859819096 21724751.526979726 16404377.771416398 1.0 0.698148515476557 0.5271725190600233 24.89123046548807 -11.689862247485783 0.08517630244425159 2.1445084782905717 2.0404766244353522e-13 0.9999213345544105 0.0017337744451637008 4.8951133961729045 0.05995089870687397 1.416502793421004 0.37380130810976536 2.0423856598876914e-12 11.689862247485783 -2.144508478290368 TCTTVAFTQVNSEDKGALAK(ub)LVEAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCTTVAFTQVNSEDKGALAKLVEAIR 26 2 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 141487000.0 43753000.0 35692000.0 62042000.0 True False 66376499.77275859 29322483.737131167 49779371.50602535 1.0 0.44176001804128473 0.7499547532100386 25.984169218098597 -10.14160523706412 5.481410992774629 1.0000079674648628 0.5958573856255871 0.6963029188796905 0.12581997376290766 1.2250940004845663e-05 1.9185963918920276e-06 0.12182706619977587 0.04060822191695602 7.21763246027859e-11 10.14160523706412 -0.40415058183927566 TCTTVAFTQVNSEDKGALAK(ub)LVEAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCTTVAFTQVNSEDKGALAKLVEAIR 26 2 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 1 186146000.0 43753000.0 80154000.0 62239000.0 True False 56639121.0005685 75693359.43897122 50912140.626068905 1.0 1.3364147977898786 0.8988864891734087 25.755295540191046 -6.7013366787997395 1.826264754839247 1.2086311290643919 0.9001631117058948 0.4238084538745973 0.14197116869632898 0.39277088470525284 2.5477591076613098 0.06199861643098263 0.1591719473479419 1.989130704165453e-07 6.7013366787997395 -0.30846801735849705 TCVHTFFDHQDQVWGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TCVHTFFDHQDQVWGVK 17 0 H0YN81;Q9GZS3;H0YL19 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 0 24413500.0 7159600.0 10664000.0 6589900.0 False True 9386304.933665019 9072972.767946435 5908040.362784407 1.0 0.9666181561399328 0.629431965457948 23.16212589940485 -6.926032715666567 0.778669075609767 1.0059513177752661 0.5667201097272182 0.9956993726037403 0.01097631248005067 0.09475086555088143 0.08816048800418978 0.009773264673907527 0.0312015185086996 1.1856794268529698e-07 6.926032715666567 -0.43923120804804794 TCVHTFFDHQDQVWGVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TCVHTFFDHQDQVWGVK 17 0 H0YN81;Q9GZS3;H0YL19 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 0 10968600.0 6896700.0 1662400.0 2409500.0 False True 6677768.033562711 2326204.989301473 1778379.6665494302 1.0 0.3483506731006348 0.26631348342907807 22.67093454852317 -13.999999999999998 0.29221957749043964 6.686077447215111 0.24445383466365403 0.9996324310473177 0.006293041431723949 16.0990012064117 0.17147550761520314 55.10094020934652 0.030675947058936733 1.0000000000000041e-14 13.999999999999998 -6.441623612551457 TCVHTFFDHQDQVWGVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TCVHTFFDHQDQVWGVK 17 0 H0YN81;Q9GZS3;H0YL19 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 0 36289600.0 6117600.0 20092000.0 10080000.0 False True 9280846.456467628 16506425.620487481 8087683.581779045 1.0 1.7785474307663498 0.8714381408759226 23.14582496119188 -6.679540336248084 1.9033060730741949 1.4928149517994687 0.87489377967554 0.32195529818101376 0.33000360699731357 0.43964090665354494 3.0787404383339667 0.13913778784235145 0.3672116824751362 2.091508643687347e-07 6.679540336248084 -0.6179211721239286 TCVHTFFDHQDQVWGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TCVHTFFDHQDQVWGVK 17 0 H0YN81;Q9GZS3;H0YL19 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 0 22007300.0 7159600.0 7443900.0 7403800.0 False True 9806697.600914955 7115003.88431452 5655174.926047385 1.0 0.7255249599672267 0.5766645568350922 23.22533596092774 -13.999999997980831 0.07475781727478915 2.5319053140848466 0.0855689465363179 0.9999073847911981 0.0016874421572219624 12.31131703934747 0.07537103115026975 3.2007889000110192 0.44911981563041964 1.0000000046493081e-14 13.999999997980831 -2.4463363675485286 TCVHTFFDHQDQVWGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TCVHTFFDHQDQVWGVK 17 0 H0YN81;Q9GZS3;H0YL19 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 0 26450300.0 6117600.0 10828000.0 9504700.0 False True 7919353.79592435 10225412.281423036 7774942.12645765 1.0 1.2911927595260975 0.981764715507341 22.91695128328433 -6.659924028317202 1.973823892378982 1.1874546506117787 0.9830719955576506 0.2350699820541019 0.12398656358251818 0.4845816478523156 3.6293922886104584 0.05075932924636963 0.13738685051930835 2.1881443653321583e-07 6.659924028317202 -0.20438265505412812 TDAGGEDAILQTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDAGGEDAILQTR 13 0 Q9NT62;Q9NT62-2 Q9NT62 ATG3 Ubiquitin-like-conjugating enzyme ATG3 0 7827400.0 2190900.0 2369400.0 3267100.0 False True 2836163.2390955025 2237540.807130006 2672521.323276883 1.0 0.7889323069583235 0.9423016582533495 21.435509140496826 -10.32474423585848 5.361790602493428 1.0000321931128924 0.8656169826696382 0.5058427442467939 0.06261277547576485 2.410144278850976e-05 3.0352617704069917e-06 0.06063907306190131 0.02020818638978574 4.734299886521231e-11 10.32474423585848 -0.13441521044325422 TDAISEEK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDAISEEKLR 10 1 Q9NR31;H0Y5E8;Q9NR31-2 Q9NR31 SAR1A GTP-binding protein SAR1a 1 7310000.0 2023500.0 3683300.0 1603200.0 True False 2652828.0956018725 3133765.9973909496 1437316.2429803107 1.0 1.18129252422591 0.5418052701429238 21.339099760662382 -6.83096474276585 1.3235668987873344 1.0968078255483613 0.5242521026296438 0.9077966652792845 0.08171347699357683 0.17962259504133538 0.6150638883452824 0.04846852879606875 0.11153904590018944 1.4758263401004062e-07 6.83096474276585 -0.5725557229187175 TDAISEEK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDAISEEKLR 10 1 Q9NR31;H0Y5E8;Q9NR31-2 Q9NR31 SAR1A GTP-binding protein SAR1a 1 8521800.0 3132200.0 1914800.0 3474800.0 True False 3032770.0254795956 2679389.625550085 2564645.638234467 1.0 0.8834793284816815 0.8456446142265269 21.532204672073817 -13.999999999999998 0.15730544853807926 1.5707016742088167 0.8073228409705455 0.9995437095105175 0.0014031448278099255 11.9927873508949 0.12524028616034663 2.088842404631766 0.03481253239150781 1.0000000000000041e-14 13.999999999999998 -0.7633788332382712 TDAISEEK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDAISEEKLR 10 1 Q9NR31;H0Y5E8;Q9NR31-2 Q9NR31 SAR1A GTP-binding protein SAR1a 1 17305000.0 6426000.0 3708300.0 7170700.0 True False 9748711.803527683 3046524.8919198536 5753408.0019705435 1.0 0.3125053805383224 0.5901711034157977 23.216780162807297 -10.39321032363992 5.9485334228403905 1.0001348329449533 0.45133824197735467 0.8388654309513635 0.11335655668514333 0.00020274928191812706 2.0681946154799193e-05 0.10978360858995923 0.03658567135208124 4.043800078523877e-11 10.39321032363992 -0.5487965909675987 TDAISEEK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDAISEEKLR 10 1 Q9NR31;H0Y5E8;Q9NR31-2 Q9NR31 SAR1A GTP-binding protein SAR1a 1 5426700.0 2023500.0 2189500.0 1213700.0 True False 2771642.633031372 2092760.6502917334 927049.0569361304 1.0 0.755061502284247 0.33447640250872024 21.402309822185273 -6.962913926232897 0.3922104495417412 1.02520307182691 0.049169114930174 0.9998634768600749 0.0032112522806504256 0.07867616924182189 0.017401807032549663 0.005424070391299322 0.035346129301862 1.089145932142983e-07 6.962913926232897 -0.9760339568967361 down TDAISEEK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDAISEEKLR 10 1 Q9NR31;H0Y5E8;Q9NR31-2 Q9NR31 SAR1A GTP-binding protein SAR1a 1 9050700.0 3132200.0 3851400.0 2067100.0 True False 2604563.0799872307 3830651.743756954 2499321.05280947 1.0 1.47074638859418 0.9595932123946574 21.312609947508093 -6.664608980077467 1.956431407924079 1.3018576918642082 0.9616995235742292 0.255388373443756 0.200214772530457 0.47363388838133436 3.489649958396155 0.08254013429435439 0.2220927340435957 2.1646666185789216e-07 6.664608980077467 -0.340158168289979 TDAISEEK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDAISEEKLR 10 1 Q9NR31;H0Y5E8;Q9NR31-2 Q9NR31 SAR1A GTP-binding protein SAR1a 1 15783600.0 6426000.0 4007700.0 5349900.0 True False 8318583.675397188 3784667.9719485627 4376273.094609584 1.0 0.45496542676393237 0.5260839182940152 22.987906484899746 -10.517952419003818 6.2455996384975005 1.0004971036586412 0.4905246725292846 0.9855961353750597 0.029034002587525098 0.00020115509427631848 1.5525540148652864e-05 0.028138036439538935 0.00937068404126897 3.0342235933749166e-11 10.517952419003818 -0.5099724311293565 TDALQPPHEYVPWVTVNGKPLEDQTQLLTLVCQLYQGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDALQPPHEYVPWVTVNGKPLEDQTQLLTLVCQLYQGK 38 1 P13284 P13284 IFI30 Gamma-interferon-inducible lysosomal thiol reductase 0 1420890000.0 623620000.0 371180000.0 426090000.0 False True 946077132.7289038 304940028.95742303 341873124.7381189 1.0 0.3223204730441391 0.361358617507228 29.817382568952283 -9.926174502255806 5.813625327796537 1.0000003762813323 0.3418395452752032 0.9973683286129592 0.015937255741640302 7.771957467627846e-08 1.4397070827648303e-08 0.015431190484515344 0.005143727172386554 1.18529239452956e-10 9.926174502255806 -0.6581608310061291 TDAPLNIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDAPLNIR 8 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 26354700.0 3789900.0 18753000.0 3811800.0 False True 5749555.378803228 15406380.632142235 3058396.0592287118 1.0 2.6795777442096886 0.5319360990075929 22.455018964059928 -6.698065922892472 1.8375410697872345 2.0449334509964237 0.5385155819707604 0.4084178731064171 0.7092281192895068 0.3996080163154977 2.6218074063367984 0.3080578154439852 0.794206798843747 2.0041677854949005e-07 6.698065922892472 -1.5064178690256633 TDASSASSFLDSDELER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDASSASSFLDSDELER 17 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;A0A0U1RQW2 Q14498-3 RBM39 RNA-binding protein 39 0 9110900.0 0.0 4773400.0 4337500.0 False True 0.0 4061227.326567467 3888697.1082379604 0.0 TDASSASSFLDSDELER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDASSASSFLDSDELER 17 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;A0A0U1RQW2 Q14498-3 RBM39 RNA-binding protein 39 0 9293200.0 2129500.0 953100.0 6210600.0 False True 2061900.1881293687 1333677.8003508402 4583857.545993723 1.0 0.6468197675275453 2.2231229098205603 20.97554306615433 -6.847890267086593 1.2453276549322354 0.8118246560929383 2.2835850580350274 0.9371643473519962 0.16930302096829694 0.15979427213524997 0.47796008925039773 0.10644008764575681 0.2459852364349018 1.4194161193613886e-07 6.847890267086593 1.4717604019420891 up TDASSASSFLDSDELER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDASSASSFLDSDELER 17 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;A0A0U1RQW2 Q14498-3 RBM39 RNA-binding protein 39 0 8194800.0 0.0 3903800.0 4291000.0 False True 0.0 3731317.207859723 3277554.175919037 0.0 TDAVDSVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDAVDSVVR 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 14081300.0 1787000.0 7952000.0 4342300.0 False True 2342774.305332617 6765592.596653219 3893000.4502828196 1.0 2.8878550448728224 1.6617052873687328 21.15978654603445 -10.128676943468866 4.800843556726639 0.9999315345150941 2.274780166117518 0.5903643055734943 0.5005735424616573 0.00044808507275762586 8.13235665727939e-05 0.48470961508464727 0.16155941610951446 7.435720495615983e-11 10.128676943468866 1.2748486316024241 TDAVDSVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDAVDSVVR 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 12833400.0 4441400.0 1516200.0 6875800.0 False True 4300410.188099442 2121626.566878549 5074821.710421481 1.0 0.4933544648251793 1.1800785247102878 22.03604284497918 -6.70903622102006 1.7985136721444512 0.6882200534335545 1.1784280078640124 0.460560010458287 0.21353018670006796 0.37702717481931985 2.3766784661083644 0.09449979803152889 0.24036627551745227 1.9541764667904384e-07 6.70903622102006 0.49020795443045784 TDAVDSVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDAVDSVVR 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 11369900.0 1787000.0 5317100.0 4265800.0 False True 2447702.1918591876 5082172.940701615 3258305.8969087424 1.0 2.0763036277878957 1.3311692524301124 21.22299660755734 -10.266252870097896 4.94052863541169 0.9998331561787621 1.7037364401095265 0.5432319676773579 0.30419983490750124 0.0005591735549687876 8.304697105077219e-05 0.29460897205338077 0.09818007454272218 5.4168539957464896e-11 10.266252870097896 0.7039032839307644 TDAVDSVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDAVDSVVR 9 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 7675200.0 4441400.0 2177300.0 1056500.0 False True 3693220.887381164 2165570.4527397878 1277409.2652959253 1.0 0.5863636426781335 0.3458794651737516 21.816448120413455 -9.076403756948718 0.16501183657715485 1.4809539431698595 6.198248459628027e-08 0.9997726042288432 0.004073676329053806 0.5319391402919853 0.055264310481747174 0.2907548191979205 0.16210478806440576 8.386799160533703e-10 9.076403756948718 -1.4809538811873748 TDDEVVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDDEVVQR 8 0 P14625;Q96GW1;A0A1W2PRR1;F8VPC7 P14625 HSP90B1 Endoplasmin 0 32563200.0 2997200.0 16432000.0 13134000.0 False True 3929358.2249260913 13980409.651434343 11775019.67022419 1.0 3.5579371620405786 2.9966775733321365 21.905862268239606 -10.10652881023055 5.243888720541729 0.9999529935196546 3.2773073676887483 0.9564289311981965 0.22913326760502753 0.00012592493059988258 2.1454586542546878e-05 0.22186183433228324 0.07395244412349267 7.82476295426571e-11 10.10652881023055 2.277354374169094 TDDEVVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDDEVVQR 8 0 P14625;Q96GW1;A0A1W2PRR1;F8VPC7 P14625 HSP90B1 Endoplasmin 0 24393200.0 8866400.0 4678800.0 10848000.0 False True 8584940.985221982 6547069.23961967 8006583.366975805 1.0 0.7626225096817462 0.9326311480484543 23.033376786181726 -9.964160028502747 5.31095144137789 1.0000004804107439 0.8476268288644425 0.5171554474059341 0.0694057359796006 3.948116024180437e-07 7.711783443670259e-08 0.06720202618451215 0.022400604964689395 1.0860253720703813e-10 9.964160028502747 -0.15237365154630134 TDDEVVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDDEVVQR 8 0 P14625;Q96GW1;A0A1W2PRR1;F8VPC7 P14625 HSP90B1 Endoplasmin 0 16503700.0 1993500.0 12127000.0 2383200.0 False True 3024285.244371684 9962842.101316545 1912159.4754063308 1.0 3.29427990294824 0.6322682289856542 21.528162787333216 -6.678679260351645 1.9067740079969218 2.453339664432644 0.6425459241589314 0.3180375685861261 0.9726523615411155 0.44144457246981944 3.1020068865617083 0.40950429258906595 1.081794106766019 2.0956595926537322e-07 6.678679260351645 -1.8107937402737129 TDDEVVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDDEVVQR 8 0 P14625;Q96GW1;A0A1W2PRR1;F8VPC7 P14625 HSP90B1 Endoplasmin 0 30128200.0 2997200.0 12505000.0 14626000.0 False True 4105345.8362844787 11952487.751494931 11171640.03192537 1.0 2.9114447912900965 2.721242126104583 21.969072329762497 -9.97531957984291 6.177397312907208 0.9999991501917673 2.81634345869747 0.9918427953776885 0.0776499129041218 9.088164494840121e-07 1.5089154891716066e-07 0.07518423959684417 0.02506140162594168 1.0584745496787882e-10 9.97531957984291 1.8163443085057027 TDDEVVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDDEVVQR 8 0 P14625;Q96GW1;A0A1W2PRR1;F8VPC7 P14625 HSP90B1 Endoplasmin 0 13956700.0 8866400.0 3050300.0 2040000.0 False True 7372804.448119144 3033867.428462858 2466554.5681057125 1.0 0.41149435737941203 0.3345476725257441 22.813782061616003 -13.999999999999998 0.2867815983926173 5.9803158838439705 0.31289110640109535 0.9996202654497683 0.0057919629032430146 15.777153969347436 0.16975724543723245 46.26966839706702 0.029489590497397276 1.0000000000000041e-14 13.999999999999998 -5.667424777442875 TDDEVVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDDEVVQR 8 0 P14625;Q96GW1;A0A1W2PRR1;F8VPC7 P14625 HSP90B1 Endoplasmin 0 4380400.0 1993500.0 1037800.0 1349100.0 False True 2580625.0477597727 980045.5177004822 1103577.6429349699 1.0 0.379770598038353 0.4276396696579303 21.299289109425665 -10.026570104796772 7.570231800874102 1.000000025489899 0.40370513640046424 0.9951898887036207 0.019542466654784887 8.408217765959465e-09 1.0801248965305122e-09 0.01892191253836214 0.006307303991483009 9.406539752899872e-11 10.026570104796772 -0.5962948890894348 TDDIPVWDQEFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDDIPVWDQEFLK 13 0 E5RJR5;P63208;E7ERH2;F8W8N3;P63208-2;E5RGM3 E5RJR5 SKP1 S-phase kinase-associated protein 1 0 9037790.0 973290.0 4856700.0 3207800.0 False True 1275992.6153537687 4132099.2912683208 2875887.6273903726 1.0 3.2383410699619897 2.253843472748495 20.283188549035636 -10.01771133729829 4.86972236332979 0.9999763375989903 2.7460922713760914 0.8074756594154351 0.4019194611453995 138745637.66688758 0.12527322030863622 44723.21267278587 0.1375877219632311 9.60038528722149e-11 10.01771133729829 1.746115933777101 TDDIPVWDQEFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDDIPVWDQEFLK 13 0 E5RJR5;P63208;E7ERH2;F8W8N3;P63208-2;E5RGM3 E5RJR5 SKP1 S-phase kinase-associated protein 1 0 9351000.0 0.0 2076200.0 7274800.0 False True 0.0 2905237.487239965 5369311.640678058 0.0 TDDIPVWDQEFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDDIPVWDQEFLK 13 0 E5RJR5;P63208;E7ERH2;F8W8N3;P63208-2;E5RGM3 E5RJR5 SKP1 S-phase kinase-associated protein 1 0 10118190.0 973290.0 5330200.0 3814700.0 False True 1333141.6151732686 5094694.1393856965 2913746.4262126186 1.0 3.821570102830777 2.1856240875309547 20.346398610558527 -9.69299431038103 6.620393505866398 0.9999999974589158 3.0035970951822732 0.6666623639614091 0.6678721640423846 4.3741513967390045e-08 8.73306186177136e-09 0.6466644421806692 0.21555481406022398 2.027709284025594e-10 9.69299431038103 2.0035970977233575 TDDIPVWDQEFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDDIPVWDQEFLK 13 0 E5RJR5;P63208;E7ERH2;F8W8N3;P63208-2;E5RGM3 E5RJR5 SKP1 S-phase kinase-associated protein 1 0 4687700.0 0.0 2385900.0 2301800.0 False True 0.0 2373046.683135928 2783095.7376792813 0.0 TDDLTCQQEETFLLAK(ub)EER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDDLTCQQEETFLLAKEER 19 1 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 142158000.0 20693000.0 30406000.0 91059000.0 True False 31392793.86093964 24979811.736837648 73061148.73742251 1.0 0.7957180188386699 2.327322284886805 24.90393009421337 -6.873278930953146 1.1165364835189633 0.881811190621386 2.4228195793904437 0.9678508225340219 0.12174538838692264 0.133753242793978 0.30964624870439394 0.08443901591775352 0.20114256263071112 1.3388165399058266e-07 6.873278930953146 1.5410083887690575 up TDDLTCQQEETFLLAK(ub)EER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDDLTCQQEETFLLAKEER 19 1 B7Z5R6;Q14596-2;Q14596 B7Z5R6 NBR1 Next to BRCA1 gene 1 protein 1 103068000.0 20693000.0 24091000.0 58284000.0 True False 26787496.42001149 22750314.672309026 47676910.04434195 1.0 0.8492885753710636 1.7798195582296041 24.675056416305818 -6.865387247438808 1.158296190305056 0.9167404394751426 1.8297268227801036 0.9598543328519881 0.08170872262767448 0.1413500908770042 0.3573617371001286 0.05488846799099083 0.12900012381333165 1.3633669208102869e-07 6.865387247438808 0.912986383304961 TDDYLDQPCYETINR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDDYLDQPCYETINR 15 0 P50395;P50395-2;Q5SX91;Q5SX87 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 28724800.0 2790800.0 14976000.0 10958000.0 False True 3658765.8261456406 12741639.175990783 9824171.2765583 1.0 3.4824964978459896 2.685105235856994 21.802925650409843 -10.015834936012116 5.646203412620494 0.9999942182413212 3.0838008668524917 0.901044893808425 0.3255336195413613 2.3692700856600826e-05 4.129326816689149e-06 0.31519744354842333 0.10506552392567911 9.641954194829414e-11 10.015834936012116 2.0838066486111706 TDDYLDQPCYETINR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDDYLDQPCYETINR 15 0 P50395;P50395-2;Q5SX91;Q5SX87 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 12765700.0 5169200.0 3584200.0 4012300.0 False True 5005106.5754770255 5015389.751356074 2961358.2635801113 1.0 1.0020545368463145 0.591667373895604 22.254969358520345 -6.905771289895041 0.9240373226337366 1.0144673945878433 0.5431601004293232 0.9892258896292889 0.020030594064738103 0.10728163568291998 0.15442157402317905 0.016063882502196654 0.04314672977429345 1.242306364297141e-07 6.905771289895041 -0.47130729415852013 TDDYLDQPCYETINR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDDYLDQPCYETINR 15 0 P50395;P50395-2;Q5SX91;Q5SX87 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 61714600.0 7565200.0 46926000.0 7223400.0 False True 11476961.49020349 38551688.66548855 5795691.823871309 1.0 3.359050102101982 0.5049848628331112 23.45223740524555 -6.687097403172572 1.8761402807080902 2.4828433838490485 0.5149447685533072 0.35732177410817423 0.9982828698382922 0.4228227926916283 2.883065527351833 0.4259781791044125 1.113593984484396 2.0554295544085328e-07 6.687097403172572 -1.9678986152957414 TDDYLDQPCYETINR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDDYLDQPCYETINR 15 0 P50395;P50395-2;Q5SX91;Q5SX87 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 21652000.0 2790800.0 9263100.0 9598100.0 False True 3822634.1785341986 8853825.613024589 7331226.459074445 1.0 2.3161582300348753 1.9178467299441213 21.866135711932735 -10.05750585556596 4.819299588596069 0.9999686465740487 2.117002480002933 0.9129359272273544 0.16260998904001858 56357186.67306307 2.015639120488483 20046.581870430087 0.055665724412121614 8.75979906769942e-11 10.05750585556596 1.117033833428884 TDDYLDQPCYETINR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDDYLDQPCYETINR 15 0 P50395;P50395-2;Q5SX91;Q5SX87 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 13213500.0 7565200.0 0.0 5648300.0 False True 9793300.53238637 0.0 4620367.356452148 1.0 0.0 0.4717885804864896 23.223363727338 -10.628315896154986 7.390286398838445 1.001368678570843 0.23589429024324718 0.7776514867224831 0.19260688144398203 0.004348882191749067 0.00021872040109414503 0.18672334630861112 0.062163603683124076 2.3533368962340778e-11 10.628315896154986 -0.765474388327596 TDEAAFQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDEAAFQK 8 0 P26447 P26447 S100A4 Protein S100-A4 0 37156800.0 5333800.0 15351000.0 16472000.0 False True 6992663.4525926765 13060690.637729324 14767635.45058117 1.0 1.867770517811321 2.111875618024454 22.737410641227473 -10.668016909813103 0.26033458096302914 2.297151085750865e-13 2.2236865304337785 0.9991616892288627 0.013814638677303802 2.384346356232456 0.13155556994357623 1.61694040594881 0.10532795341885157 2.1477468472221914e-11 10.668016909813103 2.223686530433549 TDEAAFQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDEAAFQK 8 0 P26447 P26447 S100A4 Protein S100-A4 0 29105700.0 10612000.0 8473700.0 10020000.0 False True 10275127.868715119 11857292.599761723 7395461.406443363 1.0 1.1539800527313973 0.7197439779762224 23.292653011832687 -6.810846109926871 1.4109198980553057 1.0838348234305535 0.7119955436806575 0.8620342066937876 0.06676860561343324 0.2056517594522307 0.8067031561703355 0.037207900074446146 0.08603915302281981 1.5458020897276047e-07 6.810846109926871 -0.37183927974989595 TDEAAFQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDEAAFQK 8 0 P26447 P26447 S100A4 Protein S100-A4 0 36748700.0 4392600.0 27142000.0 5214100.0 False True 6663895.342075275 22298298.038586073 4183530.8495787857 1.0 3.346135690006488 0.6277905991656747 22.667934312366373 -6.678394030932262 1.9078702700029604 2.4865713774225107 0.6383272520410824 0.31670904902878005 0.9946997072039496 0.4420766300212291 3.10979355210621 0.4185925832430058 1.1061743653215739 2.0970364006154436e-07 6.678394030932262 -1.8482441253814281 TDEAAFQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDEAAFQK 8 0 P26447 P26447 S100A4 Protein S100-A4 0 34455800.0 5333800.0 16419000.0 12703000.0 False True 7305850.000525202 15693554.289627748 9702813.02649719 1.0 2.148080550312362 1.3280881794451949 22.800620702750365 -10.217055311497894 4.917239667249932 0.9998957252094977 1.7380843648798712 0.5192924838643835 0.33476048360370936 0.0003827342442072731 6.094020462573312e-05 0.3241757708020338 0.10804348149658637 6.06659060915643e-11 10.217055311497894 0.7381886396703735 TDEAAFQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDEAAFQK 8 0 P26447 P26447 S100A4 Protein S100-A4 0 20668800.0 10612000.0 6753800.0 3303000.0 False True 8824348.191311063 6717415.9388756575 3993642.0286535122 1.0 0.7612365007865389 0.45257076693617676 23.073058287266964 -6.967610105875543 0.3100045843829707 1.0475499436380262 0.1564456965356582 0.9999572826918455 0.0014646300452212217 0.07708607380185442 0.011791995654663729 0.0048836094976983085 0.027403504260031738 1.0774320597102583e-07 6.967610105875543 -0.891104247102368 down TDEAAFQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDEAAFQK 8 0 P26447 P26447 S100A4 Protein S100-A4 0 10136000.0 4392600.0 2705400.0 3038000.0 False True 5686307.291090836 2554842.111762269 2485115.172512368 1.0 0.4492972294629824 0.4370349763555663 22.439060634458823 TDEAAFQK(ub)LMSNLDSNR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TDEAAFQKLMSNLDSNR 17 1 P26447 P26447 S100A4 Protein S100-A4 1 75170800.0 17582900.0 35069500.0 22518400.0 True False 23051352.173045795 29837267.29984029 20188411.979745418 1.0 1.2943825193356484 0.8758016375001183 24.458348044633226 -6.717714552129484 1.7675198948061337 1.1795390499101395 0.8765373779647119 0.5016445347497505 0.12391399540244233 0.3598152964187787 2.195611297353865 0.05569188419798733 0.14018568960445635 1.9155145177774508e-07 6.717714552129484 -0.3030016719454276 TDEAAFQK(ub)LMSNLDSNR ddPTM_RPMI8226_Bortezomib_2h_R1 2 TDEAAFQKLMSNLDSNR 17 1 P26447 P26447 S100A4 Protein S100-A4 1 163940200.0 71816200.0 41532400.0 50591600.0 True False 69536434.04120035 58116503.908604845 37340142.24453291 1.0 0.835770552659787 0.5369867287472474 26.0512657490656 -6.961853552346929 0.40847174033019706 1.0149658783374007 0.34673077044881184 0.9998328863344845 0.0024777129042959202 0.07904552083156548 0.018732864612274257 0.0038459470172449977 0.024958694666706707 1.0918084411217828e-07 6.961853552346929 -0.6682351078885889 TDEAAFQK(ub)LMSNLDSNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDEAAFQKLMSNLDSNR 17 1 P26447 P26447 S100A4 Protein S100-A4 1 105290900.0 34279200.0 36111700.0 34900000.0 True False 52004052.5452048 29667284.993000124 28001999.70278662 1.0 0.5704802518459822 0.5384580303322656 25.632120717447172 -13.999999999999941 0.3683469812826454 6.921073119057145 0.5350517907478297 0.9997880577205254 0.0030635097031040197 22.627581278356352 0.1968467919599999 105.71598477792318 0.008996008300788805 1.000000000000135e-14 13.999999999999941 -6.386021328309315 TDEAAFQK(ub)LMSNLDSNR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TDEAAFQKLMSNLDSNR 17 1 P26447 P26447 S100A4 Protein S100-A4 1 76228000.0 17582900.0 23705600.0 34939500.0 True False 24083773.290006086 22658208.208063837 26687509.701590113 1.0 0.9408080675409028 1.1081116476322457 24.521558106156117 -6.811053867849119 1.4099284594095178 0.9677812148997255 1.1111146977387052 0.8626146951645227 0.025674486570485988 0.2053578373085552 0.8043596226850476 0.014317153503268232 0.033105627690771064 1.545062785316772e-07 6.811053867849119 0.14333348283897973 TDEAAFQK(ub)LMSNLDSNR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TDEAAFQKLMSNLDSNR 17 1 P26447 P26447 S100A4 Protein S100-A4 1 165168200.0 71816200.0 57054000.0 36298000.0 True False 59718352.29710074 56746638.77766769 43887743.97701041 1.0 0.9502378514288425 0.7349121717000405 25.831671024499876 -6.943073161637302 0.6303267714011066 1.002348877545697 0.671189792221062 0.9985393332356006 0.004396767327777388 0.0863922451120824 0.0484325415348599 0.004387068239733952 0.01829659919208246 1.1400577162396497e-07 6.943073161637302 -0.331159085324635 TDEAAFQK(ub)LMSNLDSNR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TDEAAFQKLMSNLDSNR 17 1 P26447 P26447 S100A4 Protein S100-A4 1 125116600.0 38288700.0 48174300.0 38653600.0 True False 49565476.9331124 45493357.85638693 31619041.419428598 1.0 0.9178436418109986 0.6379246882280151 25.562832276784246 -6.948561198826456 0.5744322882433215 1.0034205470037805 0.5386345712279743 0.9990834033860982 0.004692434481087037 0.0840689040403686 0.038395024247896536 0.004946577347589799 0.023348700485336816 1.1257418232392937e-07 6.948561198826456 -0.46478597577580616 TDEFPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDEFPR 6 0 Q9BWD1;Q9BWD1-2 Q9BWD1;REV__Q13635-4 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 4340210.0 659610.0 2133900.0 1546700.0 False True 864755.097672326 1815530.437877051 1386662.320994044 1.0 2.0994735304410934 1.6035318262089964 19.72193208764896 -10.429824040395985 5.449679151205982 0.9993348647721325 1.8515026783250499 0.7971814507201898 0.20246735292250834 0.0016373675982833554 0.00017131051092536632 0.19617749428315306 0.06534605716829497 3.71685791538266e-11 10.429824040395985 0.8521678135529174 TDEFPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDEFPR 6 0 Q9BWD1;Q9BWD1-2 Q9BWD1;REV__Q13635-4 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 4349600.0 1137900.0 1001300.0 2210400.0 False True 1101777.98735497 1401124.3117105188 1631429.9294213988 1.0 1.2716938691743036 1.4807247450441083 20.071402113732024 -6.974045887098873 0.12900060116159756 0.6714095167701652 2.086415067454383 0.9999992453099474 0.00017087708332645123 0.07501036189733226 0.0038695141775679912 0.013297282365706254 0.028703351030239386 1.0615833854871938e-07 6.974045887098873 1.4150055506842178 TDEFPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDEFPR 6 0 Q9BWD1;Q9BWD1-2 Q9BWD1;REV__Q13635-4 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 4030610.0 659610.0 1396900.0 1974100.0 False True 903485.6422900044 1335180.3390694312 1507858.237865709 1.0 1.4778102457558033 1.6689343662881482 19.78514214917185 -11.354589481267867 0.16712493626694055 1.8004826803135477e-20 1.873968927192964 0.9995345976428406 0.006069118328929206 3.874150475406711 0.10142975641925715 1.5862414760273753 0.1555852129103423 4.419880410582001e-12 11.354589481267867 1.873968927192964 TDEGIAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDEGIAYR 8 0 P32119 P32119 PRDX2 Peroxiredoxin-2 0 15101000.0 5625700.0 9475300.0 0.0 False True 7375347.179356302 8061622.174430116 0.0 1.0 1.0930498562826585 0.0 22.814279532197425 -6.963890683935885 1.1799078162543744 1.0561070249103044 2.020944357657592e-20 0.9759920055829627 0.07666638048750528 0.1022737311048395 0.2819013532018565 0.054265521158867285 0.10199109018465166 1.0866991217302548e-07 6.963890683935885 -1.0561070249103044 down TDEGIAYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDEGIAYR 8 0 P32119 P32119 PRDX2 Peroxiredoxin-2 0 81091000.0 13711000.0 57308000.0 10072000.0 False True 20800589.408367254 47080939.650552295 8081264.785285576 1.0 2.263442574930761 0.38851133622371314 24.310121073562556 -6.725162315191084 1.7406760854448606 1.7643935231141445 0.3905366178454076 0.5367797576365634 0.5313534400520871 0.34538625420792723 2.047815216950117 0.24212290098270312 0.6041744676685207 1.882945217470895e-07 6.725162315191084 -1.3738569052687368 TDEGIAYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDEGIAYR 8 0 P32119 P32119 PRDX2 Peroxiredoxin-2 0 35493000.0 13711000.0 11075000.0 10707000.0 False True 17749159.784215808 10458666.514292575 8758435.863097416 1.0 0.5892485414207261 0.4934563646717647 24.081247395655005 -13.999999999999998 0.2045246854036365 3.3236925830952604 0.43394640024605224 0.9994876797620064 0.004973175459944798 12.624042050828102 0.1433771521387748 11.757874492098857 0.05900010037547049 1.0000000000000041e-14 13.999999999999998 -2.8897461828492084 TDFFIGGEEGMAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDFFIGGEEGMAEK 14 0 Q9Y266;A0A0A0MSU9 Q9Y266 NUDC Nuclear migration protein nudC 0 9309600.0 1950200.0 3432700.0 3926700.0 False True 2556731.0857636626 2920554.5405598017 3520402.751566116 1.0 1.1423002430024705 1.376915535297533 21.285868996764453 -6.963638859388362 0.3806964392464325 0.9840098505001542 1.543511624880049 0.9998822693738378 0.0016862026043718095 0.07842600437114468 0.016508008350081448 0.0030511353470126213 0.01981817104930594 1.0873294241659823e-07 6.963638859388362 0.5595017743798947 TDFFIGGEEGMAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDFFIGGEEGMAEK 14 0 Q9Y266;A0A0A0MSU9 Q9Y266 NUDC Nuclear migration protein nudC 0 11836300.0 3019400.0 1900100.0 6916800.0 False True 2923550.7997359987 2658819.838890602 5105082.580447845 1.0 0.9094488247410298 1.746192534403316 21.479290229185846 -6.880096570487086 1.0792186916373148 0.943800823793295 1.8056118866609898 0.9737650415238104 0.060727963381618434 0.12754649769616 0.2717464959029366 0.04334124539820397 0.10483963680576716 1.317963641250658e-07 6.880096570487086 0.8618110628676948 TDFFIGGEEGMAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDFFIGGEEGMAEK 14 0 Q9Y266;A0A0A0MSU9 Q9Y266 NUDC Nuclear migration protein nudC 0 8698800.0 1950200.0 2641500.0 4107100.0 False True 2671241.642173354 2524789.7957276143 3137087.568379643 1.0 0.945174616877197 1.174393030885544 21.349079058287344 -6.843571759992936 1.2656179246687327 0.9708322949812459 1.182485098266108 0.9304295895479535 0.02577738155254718 0.1646734994150782 0.5108156460476609 0.015959990627603407 0.03681347422021165 1.4336008176181983e-07 6.843571759992936 0.21165280328486202 TDFFIGGEEGMAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDFFIGGEEGMAEK 14 0 Q9Y266;A0A0A0MSU9 Q9Y266 NUDC Nuclear migration protein nudC 0 7534900.0 3019400.0 2185100.0 2330400.0 False True 2510764.882099945 2173328.4325916064 2817675.865447825 1.0 0.8656041225070367 1.1222380420946412 21.259695504620122 -6.764405960225636 1.5958609757050537 0.9223638009555147 1.1233860303414778 0.7086911044744832 0.05656889454517268 0.27558325124450933 1.3841730623589905 0.02795549823420756 0.0668931720441534 1.7202597966490772e-07 6.764405960225636 0.20102222938596304 TDFKEEPEPGFK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDFKEEPEPGFKR 13 2 P47897;P47897-2;A0A1B0GVU9;B4DDN1;H7C0R3;A0A0U1RQX5;A0A0U1RRC8 P47897 QARS Glutamine--tRNA ligase 1 28482500.0 2426400.0 3052100.0 23004000.0 True False 3681026.1936009284 2507428.9088338595 18457249.31698863 1.0 0.6811766004797133 5.0141586465955035 21.811676585072693 -6.889188867354135 1.0271455084201717 0.7626370900813453 5.38099884209551 0.9803748772843138 0.27622054945512087 0.11980468651857065 0.22569992675936584 0.20511411520403178 0.5098936657260885 1.2906578661852457e-07 6.889188867354135 4.618361752014165 up TDGCHAYLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDGCHAYLSK 10 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 26004900.0 5179700.0 11905300.0 8919900.0 False True 6790636.86028615 10129075.64649594 7996954.313722603 1.0 1.4916238130379293 1.177644229584914 22.695115453380424 -10.209431137738799 4.74505733548786 0.9999406701016281 1.334634021312724 0.602310385812389 0.1281816281897336 90192228.15168127 6.294411782873233 58465.87030481036 0.043879980760111584 6.17403180326928e-11 10.209431137738799 0.3346933512110958 TDGCHAYLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDGCHAYLSK 10 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 7620890.0 5560400.0 1448200.0 612290.0 False True 5383888.145609083 2026473.8122632303 451912.88069373264 1.0 0.37639597210353526 0.08393801439992722 22.360217006491688 -8.884658310648879 0.3450029011243342 1.1853655174250481 6.658537695204787e-16 0.9979828641506824 0.017158332826975018 0.3923869441640625 0.11940578848059441 0.1813410457594216 0.08286630742650623 1.3041924728623002e-09 8.884658310648879 -1.1853655174250475 TDGCHAYLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDGCHAYLSK 10 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 26957000.0 6007100.0 15111500.0 5838400.0 False True 9113209.877835536 12414734.758311588 4684437.680938373 1.0 1.362279035019897 0.5140271917067893 23.119527862560084 -6.790662763049688 1.4937825979985024 1.2023020675234877 0.504852321148916 0.8034398221148071 0.154074465320656 0.2343623227126053 1.0331119082172575 0.08118495066953918 0.18997439967622706 1.6193369918948057e-07 6.790662763049688 -0.6974497463745717 TDGCHAYLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDGCHAYLSK 10 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 21750600.0 5179700.0 9125000.0 7445900.0 False True 7094775.066129283 8721827.327660218 5687331.7731241025 1.0 1.2293310564979771 0.8016225630993763 22.758325514903316 -6.761048123162921 1.6083713458827331 1.133035086370447 0.7999705303641991 0.6952750000256258 0.09647284068043088 0.28116826672308654 1.4337284144512206 0.04731908393736765 0.11360481057032806 1.73361188960351e-07 6.761048123162921 -0.33306455600624796 TDGCHAYLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDGCHAYLSK 10 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 8561970.0 5560400.0 537970.0 2463600.0 False True 4623718.9674864365 535071.8488313154 2978727.3696006085 1.0 0.11572326358801023 0.64422759915703 22.140622281925964 -9.934021997869113 5.940954728870844 1.0000002880592336 0.3799754317046401 0.6472785926572349 0.21576099149961134 8.232164598166091e-07 1.4750313225147847e-07 0.2089097797655125 0.06963656056981307 1.1640670656323431e-10 9.934021997869113 -0.6200248563545935 TDGCHAYLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDGCHAYLSK 10 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 14383900.0 6007100.0 3469200.0 4907600.0 False True 7776309.367643707 3276135.9703281103 4014467.1562283463 1.0 0.42129702091839605 0.516243241676066 22.890654184652533 -10.823724187860323 7.36669922353237 1.0267123192738143 0.4687701312972347 0.9766024977236512 0.03876163231032328 0.014818724428336684 0.00035459289322577794 0.03270469150976443 0.012510263034141442 1.5006375592256523e-11 10.823724187860323 -0.5579421879765796 TDGEPGPQGWSPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDGEPGPQGWSPR 13 0 Q9H773 Q9H773 DCTPP1 dCTP pyrophosphatase 1 0 29151700.0 4901300.0 20301000.0 3949400.0 False True 7435630.433026797 16678127.937563019 3168799.358916491 1.0 2.243001193750011 0.4261641817002702 22.826023636288237 -6.7225531696109515 1.75022275187736 1.754161568456883 0.4285999812234917 0.5244969815594929 0.5229022060935766 0.35037984197671124 2.098956311123343 0.23710255319244514 0.5934149282261988 1.8942915866749938e-07 6.7225531696109515 -1.3255615872333912 TDGK(ub)IVQYECEGDTCQEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDGKIVQYECEGDTCQEEK 19 1 J3KNN7;Q7Z569;Q7Z569-2 J3KNN7 BRAP BRCA1-associated protein 1 1236700100.0 468939900.0 485370500.0 282389700.0 True False 614784750.1204513 412955113.3593909 253170722.71727657 1.0 0.6717068262973064 0.4118038429998048 29.19550613818343 -7.514331691399104 0.19002372615245422 1.21734982076249 7.932472223694373e-14 0.9999584075877095 0.0015521258949566209 0.13006084991691627 0.017916069692941683 0.03452153162157133 0.0673661853629964 3.059625759059765e-08 7.514331691399104 -1.2173498207624107 down TDGK(ub)IVQYECEGDTCQEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDGKIVQYECEGDTCQEEK 19 1 J3KNN7;Q7Z569;Q7Z569-2 J3KNN7 BRAP BRCA1-associated protein 1 194315400.0 143541500.0 43032000.0 7741900.0 True False 138984853.6531447 60214902.008915484 5714064.1379784215 1.0 0.4332479433995724 0.04111285501827871 27.050352428017995 -8.238609120279573 0.47142234083914936 1.0477866435592968 2.6774554536004526e-16 0.9947330933532427 0.02856648683500509 0.12124802973646423 0.13636101110363 0.05941824727859543 0.07628850849014272 5.772858063921238e-09 8.238609120279573 -1.0477866435592966 TDGK(ub)IVQYECEGDTCQEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDGKIVQYECEGDTCQEEK 19 1 J3KNN7;Q7Z569;Q7Z569-2 J3KNN7 BRAP BRCA1-associated protein 1 1382624400.0 35118000.0 949447000.0 398059400.0 True False 53276573.46969882 780010764.7867303 319382785.11436707 1.0 14.640783255896954 5.994807179106908 25.66699796138722 -9.592739657851173 8.092339045359584 0.9996869835893785 10.317795217502066 0.6076264785451506 3.5297049573678985 0.0 0.0 3.417622127137251 1.1392073757124168 2.554232003610096e-10 9.592739657851173 9.318108233912689 TDGK(ub)IVQYECEGDTCQEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDGKIVQYECEGDTCQEEK 19 1 J3KNN7;Q7Z569;Q7Z569-2 J3KNN7 BRAP BRCA1-associated protein 1 1189643100.0 468939900.0 376478400.0 344224800.0 True False 642319653.6542965 359844339.44041616 262925991.77228972 1.0 0.5602262633459575 0.40933823257072466 29.25871619970632 -13.999999999999998 0.14927664846672217 3.1241562302430976 0.2419428872607442 0.9995686721236631 0.005203858441098486 11.955082204300851 0.12164294527049732 7.367552825871188 0.15077640755689833 1.0000000000000041e-14 13.999999999999998 -2.8822133429823533 TDGK(ub)IVQYECEGDTCQEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDGKIVQYECEGDTCQEEK 19 1 J3KNN7;Q7Z569;Q7Z569-2 J3KNN7 BRAP BRCA1-associated protein 1 383466000.0 143541500.0 9338500.0 230586000.0 True False 119361117.2166488 9288191.646952879 278800466.4907959 1.0 0.07781589066474771 2.3357729300133268 26.83075770345227 -6.795821292695247 1.4728900079955398 0.48845030182837257 2.363821364194783 0.8196428689795154 0.39366040573224087 0.22679442727718546 0.9717180827962256 0.21030320439918912 0.4903899266701248 1.6002163642294674e-07 6.795821292695247 1.8753710623664104 TDGK(ub)IVQYECEGDTCQEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDGKIVQYECEGDTCQEEK 19 1 J3KNN7;Q7Z569;Q7Z569-2 J3KNN7 BRAP BRCA1-associated protein 1 638287300.0 35118000.0 507085300.0 96084000.0 True False 45460943.279271394 478865557.29119676 78597697.90509489 1.0 10.533559639303453 1.728906006684923 25.43812428347967 -6.627304451778193 2.090076827246097 7.293139099746214 1.7638349633862165 0.1078967554090724 4.092183558562056 0.5660843499853683 4.7088146762573855 1.6032573731516815 4.534469577342921 2.358824056147658e-07 6.627304451778193 -5.529304136359998 TDGK(ub)IVQYECEGDTCQEEK(ub)IDALQLEYSYLLTSQLESQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDGKIVQYECEGDTCQEEKIDALQLEYSYLLTSQLESQR 39 2 J3KNN7;Q7Z569;Q7Z569-2 J3KNN7 BRAP BRCA1-associated protein 2 877909000.0 278964000.0 407835000.0 191110000.0 True False 423208783.0002013 335053657.82060057 153337024.7335115 1.0 0.7916982616602293 0.36232004365901493 28.65679432761735 -6.959449733402801 0.44312009762012444 1.0148627433036077 0.12232768444116437 0.9997492447114622 0.00420418570625804 0.07989827142958958 0.02186198917503983 0.005683795233640852 0.03555637597369728 1.0978683536259457e-07 6.959449733402801 -0.8925350588624433 down TDGK(ub)VFQFLNAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDGKVFQFLNAK 12 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 358201500.0 50545000.0 89589000.0 218067500.0 True False 66264984.47847624 76222670.41518694 195503966.95116615 1.0 1.1502707050349508 2.95033596536446 25.981743391806653 -6.923419474490499 0.7989596536559036 0.964961790044135 3.2647378698500398 0.9950792383385827 0.062158565129070004 0.09620120616143484 0.09549391654144034 0.054549829598994605 0.1691486033393271 1.1928354171236408e-07 6.923419474490499 2.2997760798059046 up TDGK(ub)VFQFLNAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDGKVFQFLNAK 12 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 684218400.0 133058400.0 207660000.0 343500000.0 True False 128834533.92448585 290579720.93259424 253527045.22088754 1.0 2.2554490017630875 1.9678500592821493 26.940944116865495 -10.567683338755202 6.253275316772722 0.997799243850528 2.111649530522551 0.9521999647106302 0.11741177660705793 0.003605910126658922 0.00024929221963532037 0.11379374059081038 0.03789448795398009 2.705930645802007e-11 10.567683338755202 1.1138502866720232 TDGK(ub)VFQFLNAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDGKVFQFLNAK 12 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 374763000.0 81523000.0 189740000.0 103500000.0 True False 123676351.12962747 155879414.55461365 83043179.63433842 1.0 1.2603817393612589 0.6714556087388068 26.881994419722304 -6.786518081034328 1.5101930592275723 1.146189142318056 0.6657771742679922 0.7898501175119922 0.11046310390473366 0.24058354221346043 1.0839918288396506 0.05758556146176721 0.1351730991179644 1.6348650851784863e-07 6.786518081034328 -0.4804119680500637 TDGK(ub)VFQFLNAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDGKVFQFLNAK 12 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 293490000.0 50545000.0 68795000.0 174150000.0 True False 69232852.427265 65755409.42535726 133019356.73183417 1.0 0.94977177914833 1.9213328942582903 26.044953453329544 -6.894709771188882 0.9940699380781279 0.9535368955528017 2.0130448501432974 0.9837466788711894 0.056940241603156666 0.11540622502838181 0.20017511381576958 0.04335022338743142 0.1100796282806835 1.274354417674201e-07 6.894709771188882 1.0595079545904955 TDGK(ub)VFQFLNAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDGKVFQFLNAK 12 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 453705500.0 133058400.0 193680000.0 126967100.0 True False 110643955.08657596 192636607.39753002 153515333.5804582 1.0 1.7410495426234265 1.3874714932265078 26.72134939229977 -10.103114071239114 4.620096109413798 0.9999620766405011 1.5642605178736824 0.7725042018277007 0.14434763426392852 100509408.25927743 3.5829014099852987 43336.50287486212 0.049414034622660016 7.886529438273813e-11 10.103114071239114 0.5642984412331813 TDGK(ub)VFQFLNAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDGKVFQFLNAK 12 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 320472000.0 81523000.0 226950000.0 11999000.0 True False 105533130.55857515 214320032.9949166 9815305.120136896 1.0 2.030831757387888 0.0930068601981726 26.653120741814753 -6.7621860252510215 1.6040252634480936 1.5971554438483262 0.0851081073229787 0.699838335150752 0.4337224735740784 0.2792981290910041 1.41673676978168 0.21328405387307423 0.5114993174182118 1.7290755701233845e-07 6.7621860252510215 -1.5120473365253475 TDGSFLVHHFLSFYLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDGSFLVHHFLSFYLK 16 0 Q0PNE2;Q0PNE2-2;H7BZM9 Q0PNE2 ELP6 Elongator complex protein 6 0 14714400.0 4202700.0 5032600.0 5479100.0 False True 6375803.158525644 4134493.2101167347 4396153.483425165 1.0 0.6484662570845121 0.6895058354407764 22.604175658721164 -10.350406913039688 8.775908839680472 1.0000006592901234 0.6689860464434924 0.9886028477693825 0.01675433770530264 2.1612590391163766e-07 1.597609524469157e-08 0.016222350116498724 0.00540743924244768 4.4626526711671855e-11 10.350406913039688 -0.33101461284663103 TDGSFLVHHFLSFYLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDGSFLVHHFLSFYLK 16 0 Q0PNE2;Q0PNE2-2;H7BZM9 Q0PNE2 ELP6 Elongator complex protein 6 0 12568100.0 4202700.0 3906400.0 4459000.0 False True 5440477.997602203 3689005.405998419 3647507.753203642 1.0 0.6780664139482385 0.6704388391628857 22.375301980813614 TDGSQK(ub)TESSTEGKEQEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDGSQKTESSTEGKEQEEK 19 2 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87 P43243 MATR3 Matrin-3 1 1765200.0 620980.0 505180.0 639040.0 True False 601267.3298072673 706901.0084788975 471656.2532109347 1.0 1.1756850462929533 0.7844368550044476 19.19764704546785 -6.78464170529915 1.5178390243918962 1.0988775856352992 0.7808769409789497 0.7834589215721823 0.07445562776241821 0.24342515844323917 1.1079353415382929 0.03862543871634522 0.09079070488901018 1.6419438248578547e-07 6.78464170529915 -0.3180006446563496 TDIFGVEETAIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDIFGVEETAIGK 13 0 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 7416800.0 1531200.0 2618300.0 3267300.0 False True 2007418.0281618934 2227659.8460534643 2929231.138154672 1.0 1.109713978255559 1.4592033632560546 20.936909646591623 -6.950094698268234 0.5578012532603572 0.9953754611207023 1.5901816727674705 0.9992087055446908 0.005507913950624053 0.0834477061040037 0.03580490956635436 0.005919972335360996 0.02903836849839728 1.1217738239289813e-07 6.950094698268234 0.5948062116467682 TDIFGVEETAIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDIFGVEETAIGK 13 0 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 0 5742000.0 1531200.0 2140400.0 2070400.0 False True 2097326.019124112 2045830.0506437195 1581414.1612264672 1.0 0.9754468461217591 0.7540144673773224 21.000119708114514 -6.927937403291148 0.7635312947584736 1.0036375343401447 0.7108543776133665 0.9961171265741549 0.006893435357548643 0.09372308702352121 0.08303092871279971 0.006204853969639862 0.02026781167364814 1.1804907725407243e-07 6.927937403291148 -0.29278315672677824 TDIK(ub)VVDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDIKVVDR 8 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 11128000.0 4190200.0 3719800.0 3218000.0 True False 5493392.777954524 3164820.3396668346 2885032.2292356812 1.0 0.5761139732020513 0.5251822226900602 22.389266017661303 -13.999999999999998 0.29893121243364223 4.842898695137562 0.5125111521919506 0.9996474450645979 0.003996460614414011 16.51930838901207 0.17360943139960475 39.24090206013097 0.018491618133593315 1.0000000000000041e-14 13.999999999999998 -4.330387542945611 TDIK(ub)VVDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDIKVVDR 8 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 13226500.0 3190700.0 4863600.0 5172200.0 True False 3089412.975000875 6805660.843338937 3817445.6573259793 1.0 2.2028977344270424 1.2356540508556964 21.558901304376043 -10.351733758492964 4.939241829984235 0.9995481942386998 1.719275892641575 0.4244018850347928 0.39487558028068337 0.0019657808971757845 0.00025800523478401987 0.3825665348918535 0.12744554552082138 4.4490392944599275e-11 10.351733758492964 0.7197276984028752 TDIK(ub)VVDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDIKVVDR 8 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 9255000.0 3272000.0 2328500.0 3654500.0 True False 4963863.215241602 1912960.982346461 2932186.473175746 1.0 0.3853774569115223 0.5907065416654577 22.24303193027763 -10.200098896456637 4.942766556324456 1.0000569520087557 0.4880419992876978 0.892346741141601 0.08382524783609394 235711627.02994668 16.026620484485047 152783.59236299465 0.028695611954755198 6.308136808047968e-11 10.200098896456637 -0.5120149527210578 TDIK(ub)VVDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDIKVVDR 8 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 12080300.0 4190200.0 3248900.0 4641200.0 True False 5739430.1758972425 3105352.855324414 3545044.1485144272 1.0 0.5410559515760562 0.6176648273206377 22.452476079184194 -10.738969523245443 6.929183384797278 1.0065340447536 0.5793603894484656 0.9757267824209466 0.031275442557083866 0.0031715257681837693 0.00011947496327610107 0.0304220057611035 0.010094105680737715 1.824023699276582e-11 10.738969523245443 -0.4271736553051344 TDIK(ub)VVDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDIKVVDR 8 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 12946500.0 3190700.0 6763100.0 2992700.0 True False 2653208.4219766464 6726665.837929756 3618459.7333186124 1.0 2.5352949215042724 1.3638053095816918 21.33930657981032 -6.577538999241613 2.2760793280273965 2.04700743394672 1.366544624969312 0.0 0.6673837155114325 0.7067639207745103 6.88298063843073 0.2465566513414759 0.7467006051576814 2.6452151461920287e-07 6.577538999241613 -0.6804628089774081 TDIQIALPSGCYGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDIQIALPSGCYGR 14 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 451050000.0 128310000.0 155900000.0 166840000.0 False True 168215652.55580768 132640327.69344029 149576997.24228734 1.0 0.7885135876367698 0.8891978538838011 27.325736714477813 -10.094861192324704 4.61503088895556 1.0000104781648607 0.8388557207806285 0.7735214531931746 0.041104179586321093 4.531700529753252e-06 8.887885607181221e-07 0.03980159655712991 0.013266316914416147 8.037829834258933e-11 10.094861192324704 -0.16115475738423213 TDIQIALPSGCYGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDIQIALPSGCYGR 14 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 203474000.0 100340000.0 53151000.0 49983000.0 False True 97154761.62333907 74374471.47880335 36890952.842141524 1.0 0.7655257471285555 0.37971327627939305 26.53378136925565 -6.963673740127406 0.38012708247107974 1.0264637540938435 0.10512918717023298 0.9998831421523979 0.0027644666552252904 0.07841393348364066 0.01646482225389955 0.0050203165817030715 0.0325988099547889 1.0872420978644613e-07 6.963673740127406 -0.9213345669236105 down TDIQIALPSGCYGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDIQIALPSGCYGR 14 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 1002773000.0 124020000.0 673043000.0 205710000.0 False True 188147407.07648668 552933218.1410388 165051328.33410418 1.0 2.938829860760491 0.8772447672744522 27.48728816636985 -6.66003393384965 1.9730409087617962 2.247976842069353 0.8858847152898495 0.23567776812534524 0.8255047437843671 0.48433620695291196 3.624665635281084 0.33804501445550306 0.9149611232864722 2.1875906886122953e-07 6.66003393384965 -1.3620921267795034 TDIQIALPSGCYGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDIQIALPSGCYGR 14 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 455960000.0 128310000.0 139660000.0 187990000.0 False True 175749674.44737136 133489359.40614012 143590633.77558136 1.0 0.7595425699984087 0.8170179218088959 27.388946776000704 -10.120743626026824 7.096307845645284 1.0000001219795949 0.7882802459036524 0.9476233682476323 0.023464214120440557 4.5291688240442994e-08 5.605542971912398e-09 0.02271914083310654 0.00757304254335925 7.572798026988897e-11 10.120743626026824 -0.21171987607594245 TDIQIALPSGCYGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDIQIALPSGCYGR 14 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 190603000.0 100340000.0 26063000.0 64200000.0 False True 83437155.81569463 25922593.445899557 77623923.17273875 1.0 0.31068404947983 0.9303280105113265 26.314186644689926 -10.66892945494941 9.527518759280346 1.0002660259794958 0.6205060299956141 0.33338145815829845 0.252968587787365 0.0014304150798946404 4.9705096444016015e-05 0.2450991309807527 0.08164526063450607 2.1432387119309932e-11 10.66892945494941 -0.37975999598388166 TDIQIALPSGCYGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDIQIALPSGCYGR 14 0 P33316-2;H0YNW5;P33316;A0A0C4DGL3;H0YNJ9;H0YKC5;H0YMM5;H0YKI0;H0YMP1 P33316-2 DUT Deoxyuridine 5-triphosphate nucleotidohydrolase, mitochondrial 0 557990000.0 124020000.0 286120000.0 147850000.0 False True 160546334.79968244 270197170.4803061 120942817.06910917 1.0 1.6829856054791763 0.7533203247524303 27.2584144884623 -6.709882901536596 1.7962895531784233 1.4199506341552404 0.7555739298824669 0.4642680701386762 0.28781231139319363 0.3752962918006301 2.360620604536286 0.1275290663706241 0.3239488747824508 1.9503704056344043e-07 6.709882901536596 -0.6643767042727735 TDITYPAGFMDVISIDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDITYPAGFMDVISIDK 17 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 7487600.0 2020100.0 3397000.0 2070500.0 False True 2648370.6626762254 2890180.8414022913 1856264.5216384346 1.0 1.0913052625653663 0.7009081273248384 21.336673623410917 -6.845090502316572 1.2585753230800474 1.0485889888865971 0.6867208328126407 0.9328492708105051 0.04320658585279129 0.16293973387557828 0.4991502309445201 0.02689391869872014 0.062068637172806244 1.4285962233442052e-07 6.845090502316572 -0.3618681560739564 TDITYPAGFMDVISIDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDITYPAGFMDVISIDK 17 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 27971200.0 10652000.0 5504200.0 11815000.0 False True 10313858.09061002 7702055.76402381 8720297.057597624 1.0 0.7467676689323409 0.8454932170859311 23.298080764814607 -10.269393941525742 6.147382857118208 1.0000065771388236 0.7961304430645042 0.8504271590338969 0.04030453625881192 3.63326503713401e-06 4.3180795701325294e-07 0.03902595780391793 0.013008233142249158 5.377817480485186e-11 10.269393941525742 -0.20387613407431937 TDITYPAGFMDVISIDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDITYPAGFMDVISIDK 17 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 10579200.0 2020100.0 2192000.0 6367100.0 False True 2766985.5611498267 2095150.1920253395 4863322.114540691 1.0 0.7571959252128136 1.7576246811059348 21.39988368493381 -6.842576453789594 1.270372579639898 0.8708465129484831 1.7922447995512012 0.9287956808423625 0.11369261259109115 0.1658097473785005 0.5186810417276708 0.07014455861617257 0.1617288542432004 1.4368900790118205e-07 6.842576453789594 0.921398286602718 TDITYPAGFMDVISIDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDITYPAGFMDVISIDK 17 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 20975600.0 10652000.0 5859600.0 4464000.0 False True 8857609.963611526 5828033.171760469 5397401.760796032 1.0 0.6579690453410071 0.6093519338703577 23.078486040248883 -13.999999999999998 0.27481161204128907 3.709462916601005 0.59395199758551 0.9995937613559316 0.003503620545977083 15.124441882545227 0.1659946992649864 22.960321713419155 0.01971761732797111 1.0000000000000041e-14 13.999999999999998 -3.1155109190154953 TDITYPAGFMDVISIDK(ub)TGENFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDITYPAGFMDVISIDKTGENFR 23 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 1 23021600.0 5168700.0 3139900.0 14713000.0 True False 5004622.447703341 4393678.444362186 10859223.919461202 1.0 0.8779240572639956 2.169838790625371 22.254829804544972 -6.883744552106832 1.0586483373158273 0.919822602803417 2.268250899819532 0.976584362997203 0.0891163446851299 0.12436689514690584 0.2526561892428262 0.06460883082137557 0.15784490299536483 1.3069393914448038e-07 6.883744552106832 1.348428297016115 up TDITYPAGFMDVISIDK(ub)TGENFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDITYPAGFMDVISIDKTGENFR 23 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 1 119208800.0 7286800.0 37055000.0 74867000.0 True False 11054608.336437197 30442245.737963527 60069504.63462815 1.0 2.753805907136715 5.4338880950338595 23.39814457574383 -6.964946334142038 0.35897179306027344 0.7663276970863768 7.513063115665154 0.9999120354415915 0.017100119617548034 0.07797916871181622 0.014924160194197133 0.036033300050444986 0.22905440653504255 1.084060863367586e-07 6.964946334142038 6.746735418578777 TDITYPAGFMDVISIDK(ub)TGENFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDITYPAGFMDVISIDKTGENFR 23 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 1 18308100.0 5168700.0 5477200.0 7662200.0 True False 4298003.062234217 5447693.236460926 9264330.59399 1.0 1.2674940332939337 2.1554965084585476 22.03523507997925 -6.949154569000518 0.5680478337534167 0.9888390077842643 2.477181180110964 0.999133268269857 0.014540032920231455 0.08382698346698148 0.03738087729289393 0.015438794620874394 0.07395304070414951 1.1242047889677767e-07 6.949154569000518 1.4883421723266999 up TDITYPAGFMDVISIDK(ub)TGENFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDITYPAGFMDVISIDKTGENFR 23 1 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 1 101984800.0 7286800.0 32661000.0 62037000.0 True False 9432906.244301924 30843386.638673536 50746902.5533739 1.0 3.269764994993447 5.379773872344831 23.16927089783628 -7.156278862862598 0.22448425736836303 2.224915682619317e-12 8.322121523375074 0.9999856936046921 0.006764524878684897 0.08664514871146108 0.010028511416447025 0.08307163718072773 0.2599737195357759 6.977842091405074e-08 7.156278862862598 8.322121523372848 TDK(ub)AEVVNGYEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDKAEVVNGYEAK 13 1 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 63580000.0 14306000.0 23792600.0 25481400.0 True False 18755304.53950107 20242836.822828412 22844829.162848376 1.0 1.0793126168756368 1.2180462927026454 24.160795353180575 -6.962578295655039 0.3974346293747006 0.9921544609004203 1.3102491763241144 0.999854184600659 0.0010881247241481596 0.07879269002305768 0.017820438415017653 0.0017859176405818763 0.011634920626245472 1.0899879690149106e-07 6.962578295655039 0.31809471542369416 TDK(ub)AEVVNGYEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDKAEVVNGYEAK 13 1 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 97574900.0 31416200.0 24571900.0 41586800.0 True False 30418909.927358486 34383587.81076574 30693969.50274238 1.0 1.1303359618367343 1.0090423876477081 24.858465118701563 -10.849380728530148 2.98012779255424 0.975208883834206 1.0696891747798516 0.3056245012075498 0.04951789443142478 37026180.926467106 54151.09697082104 6298352.357345699 0.016951292380902407 1.414553154294109e-11 10.849380728530148 0.09448029094564558 TDK(ub)AEVVNGYEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDKAEVVNGYEAK 13 1 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 144347900.0 71489000.0 41574300.0 31284600.0 True False 108454039.54596809 34155041.34351149 25101185.097472683 1.0 0.3149264101779715 0.23144536803383503 26.692508548618083 -13.999999999999998 0.2969050813268951 7.139166678633306 0.21023878104953322 0.999642917682226 0.006506374859164885 16.38957684332942 0.17296236941812507 61.7032024914569 0.03057668264204007 1.0000000000000041e-14 13.999999999999998 -6.928927897583773 TDK(ub)AEVVNGYEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDKAEVVNGYEAK 13 1 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 57496800.0 14306000.0 22865000.0 20325800.0 True False 19595314.805113338 21854748.695556283 15525264.662991177 1.0 1.1153048018321887 0.7922947305209869 24.224005414703466 -6.810167974133433 1.4136954377451991 1.0628271851983884 0.7866145982594656 0.8603065510860609 0.04995422393400487 0.2065651367784327 0.8135964348594595 0.027783844034722827 0.06426880696171966 1.5482176916065694e-07 6.810167974133433 -0.2762125869389228 TDK(ub)AEVVNGYEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDKAEVVNGYEAK 13 1 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 110217600.0 31416200.0 58058000.0 20743400.0 True False 26123962.273639925 57745230.03038935 25080749.033354938 1.0 2.2104315350606862 0.960066806506698 24.63887039413584 -6.653572042823984 1.9958766586776562 1.7832229306363243 0.9653286889977801 0.20864369948117156 0.5161749462959038 0.49982463915657416 3.820429835990399 0.20945596374184558 0.5718249546944397 2.2203833252050061e-07 6.653572042823984 -0.8178942416385442 TDK(ub)AEVVNGYEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDKAEVVNGYEAK 13 1 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 129394300.0 71489000.0 44651100.0 13254200.0 True False 92543919.75886554 42166227.03352854 10842071.599576522 1.0 0.45563476394124847 0.11715595825016771 26.463634870710532 -8.396346943645375 0.35155176993131665 1.1202116108723146 2.7231283050203314e-15 0.997993724671375 0.016289394459968833 0.1404467948371065 0.09613883743955615 0.09314402215901711 0.08760875815638755 4.014699614974794e-09 8.396346943645375 -1.120211610872312 TDLCDHALHISHDEL ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDLCDHALHISHDEL 15 0 Q9Y2B0;H0YI18 Q9Y2B0 CNPY2 Protein canopy homolog 2 0 5436830.0 977630.0 2198000.0 2261200.0 False True 1281682.3973823863 1870066.9677368954 2027232.714962003 1.0 1.4590720536976887 1.5816966193046529 20.289607373801527 -11.831580903402646 0.2235924676856521 8.63728243738467e-09 1.6526355747486472 0.9993575568761038 0.00634592722443932 4.782106100095391 0.1332097833577074 2.308611924406924 0.06596790276146175 1.4737339779651233e-12 11.831580903402646 1.6526355661113648 TDLCDHALHISHDEL ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDLCDHALHISHDEL 15 0 Q9Y2B0;H0YI18 Q9Y2B0 CNPY2 Protein canopy homolog 2 0 7127330.0 977630.0 2935500.0 3214200.0 False True 1339086.2304573562 2805799.9035996296 2455072.1585269053 1.0 2.095309353335167 1.833393625209925 20.35281743532442 -10.1564583594638 4.604402382275121 0.999874884897522 1.9643514892507206 0.9475762734836393 0.10692664830018478 74846247.84915976 24.40122099689628 99951.40328737938 0.036603835788157846 6.974958701921255e-11 10.1564583594638 0.9644766043531986 TDLDDDITALK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDLDDDITALKQR 13 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 1 80784200.0 15420600.0 27527500.0 37836100.0 True False 20216555.93330283 23420504.301354576 33921183.321499154 1.0 1.1584814138779131 1.6778913002496445 24.269033906697054 -6.949447074459119 0.5648795919785548 0.9933724265662996 1.8680326154329912 0.9991571870696292 0.008405363058565632 0.08370849826655291 0.03688686020325146 0.00895787706335428 0.04322431127371645 1.1234478709379556e-07 6.949447074459119 0.8746601888666915 TDLDDDITALK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDLDDDITALKQR 13 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 1 148226100.0 28372600.0 46551900.0 73301600.0 True False 27471927.34337604 65140316.43495144 54101711.95913659 1.0 2.371159315498769 1.9693453350728032 24.711454793088738 -10.240297802044056 5.287821619732157 0.9998875130201084 2.170252325285969 0.9187626657239096 0.16403987059406142 0.00021755974778944374 3.125698575137538e-05 0.15884588478862838 0.05294364057697011 5.75045485057313e-11 10.240297802044056 1.1703648122658605 TDLDDDITALK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDLDDDITALKQR 13 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 1 226930500.0 47515000.0 57980500.0 121435000.0 True False 72083728.81179863 47633426.77128578 97433319.02314869 1.0 0.6608069193486168 1.3516686862514367 26.103170306316777 -6.773179249475469 1.5620927769147392 0.8062431469939645 1.3560497817015216 0.7426592763651787 0.143084764992203 0.26130813911924206 1.2587624545536722 0.07217870028819193 0.17133257980628047 1.6858570658998043e-07 6.773179249475469 0.5498066347075571 TDLDDDITALK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDLDDDITALKQR 13 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 1 74475000.0 15420600.0 23037200.0 36017200.0 True False 21122012.546045773 22019340.33016701 27510679.157518305 1.0 1.0424830627368047 1.302464862074355 24.332243968219945 -6.935417681319975 0.7008899612482545 0.9967264736804433 1.3640350419527194 0.9975001034383094 0.006684841127086745 0.08992043618322608 0.06460201972384726 0.006300143327585482 0.02286388225014925 1.1603321313474694e-07 6.935417681319975 0.3673085682722761 TDLDDDITALK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDLDDDITALKQR 13 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 1 114806200.0 28372600.0 47772000.0 38661600.0 True False 23593074.019298177 47514642.75400046 46745561.80895881 1.0 2.013923353740823 1.9813256115215356 24.491860068523014 -10.020410078046966 5.115500868625994 0.9999905233652332 1.9976244826346419 0.9991998810340539 0.013307972553590279 1.4759906121630917e-06 2.826395412746396e-07 0.012885514408277905 0.004295129669836029 9.540912698022045e-11 10.020410078046966 0.9976339592694087 TDLDDDITALK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDLDDDITALKQR 13 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 1 276757800.0 47515000.0 41652800.0 187590000.0 True False 61509104.160675 39334785.06424609 153450544.83594316 1.0 0.6394953332679855 2.4947614979905635 25.874296628409226 -6.856301497608763 1.2042269898389923 0.8060126089448993 2.5784826708794952 0.948990224379984 0.18140729266938488 0.15066102656068897 0.417274483432492 0.1176546726200222 0.27360633906675913 1.3921899758330052e-07 6.856301497608763 1.7724700619345959 up TDLK(ub)GDDLEEGVTSEEFDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDLKGDDLEEGVTSEEFDK 19 1 Q6ZVM7-3;Q6ZVM7-5;Q6ZVM7;F5H3S6;Q6ZVM7-4;Q6ZVM7-2 Q6ZVM7-3 TOM1L2 TOM1-like protein 2 1 18751900.0 5200500.0 7822800.0 5728600.0 True False 6817905.861713638 6655668.733035561 5135859.424611415 1.0 0.9762042580275082 0.7532898706407996 22.70089724891695 -6.927283710314337 0.7687594547909686 1.0037531749504942 0.7105389220667486 0.9959769583921018 0.007047867684693691 0.09407300238869953 0.08477060751197497 0.006320090179454919 0.020479429025887546 1.1822689659321763e-07 6.927283710314337 -0.2932142528837456 TDLK(ub)GDDLEEGVTSEEFDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDLKGDDLEEGVTSEEFDK 19 1 Q6ZVM7-3;Q6ZVM7-5;Q6ZVM7;F5H3S6;Q6ZVM7-4;Q6ZVM7-2 Q6ZVM7-3 TOM1L2 TOM1-like protein 2 1 24883100.0 6976100.0 8517100.0 9389900.0 True False 6754647.524024071 11918022.44608975 6930403.499038166 1.0 1.7644181141504784 1.0260200068751166 22.687449057067564 -10.400771724984773 4.338594409631646 0.9990068167513989 1.3952190605146324 0.27639717661713636 0.30144976498312553 0.0029029645868147587 0.00040094396321042983 0.29258171413519196 0.09729249329061694 3.974003772205934e-11 10.400771724984773 0.3962122437632335 TDLK(ub)GDDLEEGVTSEEFDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDLKGDDLEEGVTSEEFDK 19 1 Q6ZVM7-3;Q6ZVM7-5;Q6ZVM7;F5H3S6;Q6ZVM7-4;Q6ZVM7-2 Q6ZVM7-3 TOM1L2 TOM1-like protein 2 1 18626100.0 5200500.0 7240500.0 6185100.0 True False 7123265.388228149 6920590.768868366 4724306.766133023 1.0 0.9715475125081369 0.6632220630078411 22.76410731043984 -6.924918568714291 0.7873837432886868 1.0056747192789188 0.6074044104731128 0.9954417947874582 0.01029564336122886 0.09536349623343515 0.09124440923836963 0.009110279128270128 0.028716926208087634 1.1887250954273146e-07 6.924918568714291 -0.39827030880580605 TDLK(ub)GDDLEEGVTSEEFDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDLKGDDLEEGVTSEEFDK 19 1 Q6ZVM7-3;Q6ZVM7-5;Q6ZVM7;F5H3S6;Q6ZVM7-4;Q6ZVM7-2 Q6ZVM7-3 TOM1L2 TOM1-like protein 2 1 21813900.0 6976100.0 9411900.0 5425900.0 True False 5800936.243630326 9361196.226584125 6560430.603472943 1.0 1.6137388575616765 1.1309261691466743 22.46785433250184 -10.182544767106698 4.470019237227106 0.9999188818048093 1.3723325133605961 0.4422585464455129 0.1971074546881642 22349713.59016803 50911875.37820333 11082.97307948413 0.06747512230847552 6.568334065513604e-11 10.182544767106698 0.3724136315557869 TDLK(ub)GDDLEEGVTSEEFDKFLEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDLKGDDLEEGVTSEEFDKFLEER 24 2 Q6ZVM7-3;Q6ZVM7-5;Q6ZVM7;F5H3S6;Q6ZVM7-4;Q6ZVM7-2 Q6ZVM7-3 TOM1L2 TOM1-like protein 2 1 29185900.0 11620700.0 10518000.0 7047200.0 True False 11251807.23934957 14717892.250645386 5201326.908531707 1.0 1.3080469597074416 0.46226590963465336 23.423653406618048 -6.808151997256239 1.4222799753669515 1.1682545909049744 0.44808637646560834 0.8549435202774216 0.1331142286906747 0.2093355985562437 0.8349446149305743 0.07359906334837094 0.1703973411487944 1.555421159742937e-07 6.808151997256239 -0.7201682144393661 down TDLK(ub)GDDLEEGVTSEEFDKFLEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDLKGDDLEEGVTSEEFDKFLEER 24 2 Q6ZVM7-3;Q6ZVM7-5;Q6ZVM7;F5H3S6;Q6ZVM7-4;Q6ZVM7-2 Q6ZVM7-3 TOM1L2 TOM1-like protein 2 1 53487400.0 22964500.0 22958000.0 7564900.0 True False 34838825.4298337 18860965.528327283 6069694.199186545 1.0 0.5413777673507896 0.1742221250085215 25.05419264936763 -7.965638558262356 0.34111996553444973 1.0908106553944008 1.0375946808712041e-22 0.9986987724929958 0.012185698080040254 0.10143832032762715 0.06690403683270246 0.05000926874969269 0.08564959255857275 1.0823343497165519e-08 7.965638558262356 -1.0908106553944008 down TDLK(ub)GDDLEEGVTSEEFDKFLEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDLKGDDLEEGVTSEEFDKFLEER 24 2 Q6ZVM7-3;Q6ZVM7-5;Q6ZVM7;F5H3S6;Q6ZVM7-4;Q6ZVM7-2 Q6ZVM7-3 TOM1L2 TOM1-like protein 2 1 35299100.0 11620700.0 17562100.0 6116300.0 True False 9663126.93429781 17467489.481496073 7395190.051424011 1.0 1.807643592003108 0.765299897404421 23.204058682052324 -6.6998623624925715 1.8314456938901722 1.50158970867014 0.7684200325552093 0.4168552492710016 0.3409261533252163 0.3958256034445276 2.581118646009007 0.1485158634040322 0.3819964157113016 1.9958947578498633e-07 6.6998623624925715 -0.7331696761149307 TDLVPEEDVK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDLVPEEDVKK 11 1 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;Q9BRT8-2;F2Z2T4 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 1 4605540.0 515040.0 1337700.0 2752800.0 True False 498690.33711864287 1871850.5860133437 2031759.0977701896 1.0 3.7535328974461635 4.074189825913583 18.927784723306946 -10.032064703387611 0.5007620346472835 3.127807350171958e-23 4.065144484850249 0.9992542781319175 0.03768030386418062 1.323157912085683 0.2298751173626735 2.062328303941105 0.06482300071606598 9.28827994980395e-11 10.032064703387611 4.065144484850249 TDLVPEEDVK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDLVPEEDVKK 11 1 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;Q9BRT8-2;F2Z2T4 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 1 38707000.0 1702300.0 3759700.0 33245000.0 True False 2582513.5548000587 3088752.16032982 26674111.17819884 1.0 1.1960255366671075 10.32874004809008 21.300344490686147 -6.911533032359826 0.8852222917041288 0.730757911907103 11.548558929216572 0.9914875201355227 0.4015421551690647 0.10341318348423695 0.13333006819654417 0.3312602082800291 0.9244482937917583 1.2259336548394732e-07 6.911533032359826 10.817801017309469 up TDLVPEEDVK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDLVPEEDVKK 11 1 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;Q9BRT8-2;F2Z2T4 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 1 6627740.0 515040.0 1733700.0 4379000.0 True False 428278.58014067594 1724360.2139874953 5294628.65379163 1.0 4.026258360670519 12.36258103791348 18.708189998741222 -6.953351512527537 0.5207535141790277 0.8591644042203812 15.902174402255092 0.9994387194010466 0.11382837244307495 0.08216724489608836 0.03060408310207795 0.12879885120514534 0.6886360855966215 1.1133930024115925e-07 6.953351512527537 15.04300999803471 TDLVPEEDVK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDLVPEEDVKK 11 1 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;Q9BRT8-2;F2Z2T4 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 1 62254300.0 1702300.0 3146000.0 57406000.0 True False 2203660.9073496168 2970922.334443739 46958697.03530117 1.0 1.348175812592202 21.309402403375778 21.071470812778596 -6.910684693469952 0.8910646494682635 0.3952662841596431 23.92714798949731 0.9911772860780034 0.8916654723865989 0.10396680513275848 0.13632618194777815 0.7324993545865092 2.0317367569176676 1.2283307003042724e-07 6.910684693469952 23.531881705337668 up TDMDNQIVVSDYAQMDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDMDNQIVVSDYAQMDR 17 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 4508700.0 1055200.0 2138400.0 1315100.0 False True 1383377.4185713374 1819359.0554179135 1179026.0673299693 1.0 1.3151574046197962 0.8522808392720412 20.399763381357143 -6.723362556239447 1.7470450674225044 1.1910431823413228 0.852853325617558 0.5284216102237018 0.1325675187875791 0.3488206378177944 2.0823982166905695 0.06020700763966469 0.1505574057157016 1.8907645180151659e-07 6.723362556239447 -0.3381898567237648 TDMDNQIVVSDYAQMDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDMDNQIVVSDYAQMDR 17 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 8420900.0 2228400.0 1153800.0 5038700.0 False True 2157660.661764492 1614518.3569875122 3718913.312240136 1.0 0.7482726017107766 1.7235858159451647 21.041036557373207 -6.838204070243844 1.2907789209521654 0.8660425761604186 1.7545271048814008 0.9213107276937047 0.11596847487803223 0.17090718419591483 0.5539161761892899 0.07047093693531536 0.162275507818728 1.451429446449567e-07 6.838204070243844 0.8884845287209823 TDMDQIITSKEHLASK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDMDQIITSKEHLASK 16 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 8559700.0 2018900.0 2593900.0 3946900.0 True False 2646797.4510554136 2206900.230943006 3538512.6493381923 1.0 0.8338001950481712 1.3369034521048093 21.335816364633992 -6.817677269423272 1.3817501691729452 0.9101977649574168 1.347359846287664 0.8789617122100418 0.07281486211120348 0.19653718778620022 0.737913920984653 0.04141558220842274 0.09552707676955148 1.521677890766569e-07 6.817677269423272 0.43716208133024714 TDMDQIITSKEHLASK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDMDQIITSKEHLASK 16 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 11823000.0 2872700.0 3012600.0 5937700.0 True False 2781507.710936479 4215546.8905014545 4382438.242818237 1.0 1.5155618206365364 1.5755621404848656 21.4074356743816 -11.656032730105448 0.35621427455970983 1.4548980466399039e-08 1.5841735310821503 0.9995670218765995 0.005375656897815722 4.330455716664381 0.18395199304281667 3.304305148385134 0.017511576592630727 2.2078383355452626e-12 11.656032730105448 1.5841735165331698 TDMDQIITSKEHLASK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDMDQIITSKEHLASK 16 1 Q96TA1-2;Q96TA1 Q96TA1-2 FAM129B Niban-like protein 1 1 10744400.0 2018900.0 3667300.0 5058200.0 True False 2765341.888721051 3505266.5598606383 3863557.3368990095 1.0 1.2675707745785447 1.3971355052542433 21.399026426156883 -12.67469352769512 0.10788861213245879 8.82426061855174e-16 1.6602190358148012 0.9997932973829792 0.002377411026363998 7.497628209977696 0.0861815542801873 1.8505909434944272 0.21160214742290787 2.1149810101039957e-13 12.67469352769512 1.6602190358148003 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK 35 0 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 19407500.0 1946900.0 9766200.0 7694400.0 False True 2552404.7538064197 8309121.028349447 6898257.297896528 1.0 3.2554088515773194 2.7026502311630263 21.283425695451758 -10.344429085050661 6.0029380977686655 0.9997703319115133 2.9790295413701746 0.9447244691469389 0.2256627618233054 0.0006937006285463849 7.575767716901432e-05 0.21852015764016913 0.07283234320006844 4.524503358780849e-11 10.344429085050661 1.9792592094586614 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK 35 0 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 22696100.0 6049800.0 3850300.0 12796000.0 False True 5857752.41049309 5387744.869049249 9444343.728228467 1.0 0.9197631602520605 1.6122811389758733 22.481915785466942 -6.8780416953003956 1.0906136771255255 0.9514434224271348 1.6595624045423727 0.9720733858981866 0.05168518538875775 0.1293812192587673 0.2828612158491035 0.03656706195354752 0.08800851297244128 1.324214395270429e-07 6.8780416953003956 0.7081189821152379 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK 35 0 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 32477700.0 2470900.0 28726000.0 1280800.0 False True 3748535.946986705 23599620.862737596 1027649.3186054166 1.0 6.295690156501865 0.2741468491002472 21.837895806414803 -6.674484325168562 1.9216110683584853 4.367184368336751 0.29809389936967046 0.29894135925073306 2.247214533950896 0.4509451827858999 3.2144276116096813 0.9400785118628321 2.496936734840051 2.1160000558766064e-07 6.674484325168562 -4.069090468967081 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK 35 0 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 19413600.0 1946900.0 7773100.0 9693600.0 False True 2666721.5429942096 7429658.739795699 7404171.32595869 1.0 2.7860646940488722 2.7765071105418997 21.34663575697465 -10.063113415370635 4.948149641152864 0.9999588150190245 2.7812859022909375 0.9999784085510339 0.0039018671726802987 1.7734024379119458e-06 3.357793911903281e-07 0.003778053136839155 0.0012593222084818709 8.647420631572685e-11 10.063113415370635 1.781327087271913 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK 35 0 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 10059600.0 6049800.0 2879900.0 1129900.0 False True 5030676.751582513 2864385.407084608 1366156.865932671 1.0 0.5693837128739292 0.27156522539495614 22.26232106090122 -8.171911556725906 0.23990176453102313 1.208931475709098 1.3980554448632504e-11 0.9995873674673118 0.006074198912035518 0.08786783947719531 0.050168775605538764 0.08952697552301618 0.10420290802984204 6.731137207011092e-09 8.171911556725906 -1.2089314756951175 down TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK 35 0 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 4942490.0 2470900.0 1487600.0 983990.0 False True 3198628.7587206545 1404813.752294505 804913.9165900091 1.0 0.4391924972425946 0.25164343139087764 21.609022128507252 -13.999999999999998 0.15301771202019565 3.725115614973848 0.052293434308588314 0.9995564814268174 0.006695572349157418 11.970348547742278 0.1233432825503142 9.691564787385886 0.1802309912155567 1.0000000000000041e-14 13.999999999999998 -3.6728221806652597 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK(ub)TPASPVVHIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIR 45 1 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 68315400.0 29935600.0 24533800.0 13846000.0 True False 28985310.76391902 34330274.282076836 10219317.228903672 1.0 1.1844024913754327 0.35256883433607 24.788818617657718 -6.848546387944114 1.2419694048089929 1.098302626091713 0.3202165043710895 0.9381726583253776 0.08869400598016647 0.15906984376057745 0.47287617047268604 0.05589910757360544 0.12924847895306277 1.4172733212924875e-07 6.848546387944114 -0.7780861217206235 down TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHK(ub)TPASPVVHIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIR 45 1 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 1 41556000.0 29989000.0 4761900.0 6805100.0 True False 41076743.7222525 4551503.51250249 5197875.535433839 1.0 0.11080487643514945 0.12654059364053227 25.29181848359992 -10.044015017406172 4.8102761425379885 1.0000219826038632 0.11867273502534303 0.9997609677655218 0.006424079702625601 71713299.95319885 136572314.93719038 24311.042480746226 0.002350955072247836 9.036182270978868e-11 10.044015017406172 -0.8813492475785202 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIR 45 1 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 12331500.0 3441400.0 2219900.0 6670200.0 False True 3332154.640727123 3106317.646625565 4923074.5182892755 1.0 0.9322249359794788 1.477444791462317 21.668023925079613 -6.875761873528277 1.103211910893132 0.9599499735866647 1.5130692270813342 0.9701008080062329 0.04195359979288773 0.13144803833914173 0.2955640858623369 0.02939836703505268 0.07038483376715049 1.331184114766026e-07 6.875761873528277 0.5531192534946695 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIR 45 1 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 97571600.0 5385000.0 85303000.0 6883600.0 False True 8169438.696233506 70080013.17461902 5523053.442810941 1.0 8.578314346973334 0.6760627808318491 22.961805526767453 -6.655685279783407 1.9881122143766736 5.895369082308093 0.7091929763219045 0.2173873036127011 3.230048819509755 0.49481318715526007 3.7549837930453505 1.3146804291230187 3.5793942826806955 2.2096053878869263e-07 6.655685279783407 -5.186176105986188 TDPFIFPECPHVYFCGNTPSFGSK(ub)IIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDPFIFPECPHVYFCGNTPSFGSKIIR 27 1 A0A087WWF6;P49005 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 275118900.0 6663900.0 50075000.0 218380000.0 True False 10109623.49634736 41138725.012239255 175217097.28064594 1.0 4.0692638085980954 17.33171342572277 23.26922593345375 -6.94310608238648 0.6300163166088005 0.8553292207852126 21.260427056124247 0.998542964004954 0.2705211770777946 0.08637801377846131 0.04837049369201341 0.26999875133496665 1.1267892578213738 1.1399712999179465e-07 6.94310608238648 20.405097835339035 TDPFIFPECPHVYFCGNTPSFGSK(ub)IIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDPFIFPECPHVYFCGNTPSFGSKIIR 27 1 A0A087WWF6;P49005 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 1 289539900.0 6663900.0 21582000.0 261294000.0 True False 8626549.915107273 20380942.727897268 213741173.10284656 1.0 2.3625832955774215 24.77713282902724 23.0403522555462 -6.919339512398437 0.8296209777773215 0.49356468214983457 28.337212079184198 0.9939952637929812 0.8447741448575617 0.09856187488199057 0.10764292521385077 0.7253250401736894 2.159129068282362 1.2040942641977636e-07 6.919339512398437 27.843647397034363 up TDPKDPANYILHAVLVHSGDNHGGHYVVYLNPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDPKDPANYILHAVLVHSGDNHGGHYVVYLNPK 33 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 58819400.0 18222000.0 9869400.0 30728000.0 False True 17643552.584218506 13810302.88824108 22679414.97975962 1.0 0.7827393503842235 1.2854222454068294 24.072637745492607 -6.789262837205756 1.4995118607600804 0.8784588586321009 1.2906440798819583 0.7988760827127848 0.09231602904406992 0.23644042208272406 1.0503340532892087 0.04846281776951014 0.11351310232505565 1.6245652631013416e-07 6.789262837205756 0.41218522124985735 TDPKDPANYILHAVLVHSGDNHGGHYVVYLNPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDPKDPANYILHAVLVHSGDNHGGHYVVYLNPK 33 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 321265000.0 39714000.0 126121000.0 155430000.0 False True 60249041.48230595 103613722.16212931 124709192.372611 1.0 1.7197571880468634 2.0698950440437436 25.844434953525525 -9.9869926113989 0.1703032695912136 6.390836643556709e-13 2.4917735473102534 0.999613681662155 0.008754062272273424 1.5336509363249757 0.07855018269948393 0.9581968387656715 0.2600125743434544 1.0304036504289881e-10 9.9869926113989 2.4917735473096143 TDPKDPANYILHAVLVHSGDNHGGHYVVYLNPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDPKDPANYILHAVLVHSGDNHGGHYVVYLNPK 33 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 34030100.0 18222000.0 5086100.0 10722000.0 False True 15152400.37147287 5058700.169788192 12963920.627073284 1.0 0.33385470590601 0.8555687751942065 23.853043020926883 -10.084248960807235 7.168495183398486 1.0000001104605298 0.5947117405502527 0.4458728991053287 0.21298887689785176 3.7573566671346544e-07 4.8012346614354384e-08 0.20622564860152903 0.06874186442940014 8.236658103887284e-11 10.084248960807235 -0.40528836991027717 TDPKDPANYILHAVLVHSGDNHGGHYVVYLNPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDPKDPANYILHAVLVHSGDNHGGHYVVYLNPK 33 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 273645000.0 39714000.0 119619000.0 114312000.0 False True 51410555.87997567 112962097.49644811 93508388.94016922 1.0 2.1972549326284696 1.8188558232763747 25.615561275617974 -10.041642369276436 4.972318406494299 0.9999837237926701 2.0080553778087182 0.9044208310505658 0.15448078953620925 53455331.1050568 3.0923670976142716 10592.279713964535 0.05288288320178451 9.085684057324265e-11 10.041642369276436 1.0080716540160481 TDPSILGGMIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDPSILGGMIVR 12 0 P48047 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 38761500.0 7545500.0 12829000.0 18387000.0 False True 9892223.570725948 10914963.207050342 16484489.620558266 1.0 1.103388245222337 1.6664089223924141 23.23786341527248 -6.937920127796275 0.6786399442028422 0.9933952852610127 1.8093761382499185 0.9978785598212194 0.013487811801725836 0.08872844323912449 0.059028104946471184 0.012931016751674278 0.04891871092247774 1.1536654118543131e-07 6.937920127796275 0.8159808529889058 TDPSILGGMIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDPSILGGMIVR 12 0 P48047 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 29206800.0 10319000.0 3572800.0 15315000.0 False True 9991428.99333502 4999437.671905865 11303542.059848318 1.0 0.5003726369111804 1.1313238644230539 23.252259599110012 -6.695599662827246 1.845831631117497 0.6884358869837779 1.1293440206248964 0.3970237899609832 0.21107209021812304 0.4047657330808694 2.677744717174051 0.09132016978128271 0.23619931052444337 2.0155813776593963e-07 6.695599662827246 0.44090813364111847 TDPSILGGMIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDPSILGGMIVR 12 0 P48047 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 38068900.0 5863400.0 25090000.0 7115500.0 False True 8895206.471958332 20612493.47093524 5709118.3061655555 1.0 2.3172585747070666 0.6418196501861142 23.084596662462843 -6.697061897790065 1.841577075534615 1.8203095613958489 0.6471033732197233 0.40358800028027353 0.5563349686890693 0.40164102958886394 2.646123757810445 0.24121044149331297 0.622536367687657 2.0088064872036116e-07 6.697061897790065 -1.1732061881761255 TDPSILGGMIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDPSILGGMIVR 12 0 P48047 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 27631800.0 7545500.0 9511300.0 10575000.0 False True 10335275.259470345 9091059.316336954 8077402.798961489 1.0 0.8796146293255905 0.7815372688366535 23.30107347679537 -6.973461701125065 0.15453183126500916 1.1070359679724353 0.5515262592105746 0.999998336284325 0.00011509301851875011 0.07519457425060473 0.004744240769555135 0.004786144692508303 0.012015893684533126 1.0630123223919068e-07 6.973461701125065 -0.5555097087618607 TDPSILGGMIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDPSILGGMIVR 12 0 P48047 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 19256600.0 10319000.0 4141400.0 4796200.0 False True 8580705.709210213 4119089.456196461 5799063.244876772 1.0 0.48004087260272565 0.6758259100591542 23.032664874544288 -10.115943304658085 5.198257232144477 1.000010710922689 0.5779333913304459 0.8610422605145343 0.07992890684171655 9.92200052183039e-06 1.6874472886937195e-06 0.0773927939137968 0.02579694375629594 7.656965588944171e-11 10.115943304658085 -0.42207731959224315 TDPSILGGMIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDPSILGGMIVR 12 0 P48047 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 19074600.0 5863400.0 5935100.0 7276100.0 False True 7590286.88489323 5604806.4676278 5951924.459090607 1.0 0.7384182643719192 0.7841501315235637 22.855722984555292 -10.379605169489553 5.836804073881103 1.0000571160407028 0.7612841979477473 0.9732117599255121 0.018669956584380656 1.3879760578188052e-05 1.475251074571103e-06 0.018081422266059702 0.006025702577143291 4.1724854461370504e-11 10.379605169489553 -0.23877291809295553 TDPSSLGATSASFNFGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDPSSLGATSASFNFGK 17 0 Q9UKX7;Q9UKX7-2 Q9UKX7 NUP50 Nuclear pore complex protein Nup50 0 7475900.0 1864300.0 2910400.0 2701200.0 False True 2444115.35390688 2476179.664650348 2421705.73574003 1.0 1.0131189842133326 0.9908311945542879 21.22088094637202 -6.747189924365056 1.6601392703729092 1.0077401038793865 0.9907959689904036 0.6368136967911309 0.005512109418975951 0.30498301836866915 1.6528667931380592 0.0026238071506658493 0.0063890663586326744 1.789822962832239e-07 6.747189924365056 -0.016944134888982942 TDPSSLGATSASFNFGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDPSSLGATSASFNFGK 17 0 Q9UKX7;Q9UKX7-2 Q9UKX7 NUP50 Nuclear pore complex protein Nup50 0 6100100.0 1864300.0 2311200.0 1924600.0 False True 2553582.09081314 2209083.5418836507 1470049.118381211 1.0 0.8650920406401386 0.5756811671220258 21.28409100789491 -6.9586507328555935 0.45404945016844567 1.0089561456466145 0.4202660325329375 0.99971683728452 0.002978685053653754 0.08018667461882462 0.02293909040469511 0.0038923654039081457 0.02392544357240782 1.0998900344583963e-07 6.9586507328555935 -0.588690113113677 TDPTTLTDEEINR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDPTTLTDEEINR 13 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 7231100.0 0.0 3306700.0 3924400.0 False True 0.0 2813353.2494156444 3518340.733502956 0.0 TDPTTLTDEEINR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDPTTLTDEEINR 13 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 8663000.0 2308800.0 1351200.0 5003000.0 False True 2235508.407773223 1890741.2064149124 3692564.2132171756 1.0 0.8457768263543544 1.6517782712771445 21.092171541207826 -6.857158266397576 1.2001325400388148 0.9168832492194299 1.6887185498828339 0.9500738579401312 0.0780532494070575 0.14976283777145386 0.41153024224609464 0.05078294304053616 0.1181794611621856 1.389446194391085e-07 6.857158266397576 0.771835300663404 TDPTTLTDEEINR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDPTTLTDEEINR 13 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 9727100.0 0.0 4374400.0 5352700.0 False True 0.0 4181124.5437936313 4088502.5023169033 0.0 TDQAQDVK(ub)K(ub)IEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDQAQDVKKIEK 12 2 P49458 P49458 SRP9 Signal recognition particle 9 kDa protein 2 4018900.0 820100.0 1132600.0 2066200.0 True False 794066.3744000447 1584853.0864309755 1525000.2353286678 1.0 1.9958697881249639 1.9204946645434757 19.59890007880198 -10.119417853661275 5.377360104510817 0.999982370763163 1.9581822263346662 0.9953803381257492 0.03077176534721353 6.5038327648861135e-06 1.0651106540545433e-06 0.0297951809856681 0.009931544560036575 7.595950856820695e-11 10.119417853661275 0.9581998555715032 TDQAQDVK(ub)K(ub)IEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDQAQDVKKIEK 12 2 P49458 P49458 SRP9 Signal recognition particle 9 kDa protein 2 5802250.0 755250.0 1790100.0 3256900.0 True False 1145769.4661709124 1470642.6688848627 2613172.2874500207 1.0 1.283541508397545 2.280713847422618 20.127885366063826 -6.947833852609801 0.5821383182340268 0.9881734027909151 2.6255852765541214 0.9990201537914322 0.017192566389348754 0.08436738168943117 0.03965320776970511 0.017971916616777703 0.08334864904879506 1.1276287689180085e-07 6.947833852609801 1.6374118737632064 up TDQAQDVK(ub)K(ub)IEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDQAQDVKKIEK 12 2 P49458 P49458 SRP9 Signal recognition particle 9 kDa protein 2 3841300.0 820100.0 1831600.0 1189600.0 True False 681949.4865901062 1821732.8072558648 1438339.8599110588 1.0 2.671360332515125 2.1091589453392903 19.379305354236255 -10.55616962012526 7.414543185353082 0.9992883010899354 2.3902596389272066 0.8907527683811133 0.22951775521094694 0.0027012010354544487 0.00016169223350206153 0.22231043983818585 0.07407653696590902 2.778627821663232e-11 10.55616962012526 1.3909713378372712 TDQAQDVK(ub)K(ub)IEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDQAQDVKKIEK 12 2 P49458 P49458 SRP9 Signal recognition particle 9 kDa protein 2 7447750.0 755250.0 2934400.0 3758100.0 True False 977686.0132031944 2771098.060455091 3074164.361362326 1.0 2.83434356534992 3.1443268287028427 19.899011688156275 -10.16638609596955 0.40254235834560403 2.453499085719708e-18 3.174289988521873 0.9990535652507053 0.029111583229247274 1.523610663794877 0.1841661368092886 1.8042194675252048 0.07824965508176161 6.817323517630976e-11 10.16638609596955 3.174289988521873 TDQAQK(ub)AEGAGDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDQAQKAEGAGDAK 14 1 P05204 P05204 HMGN2 Non-histone chromosomal protein HMG-17 1 75130800.0 40497000.0 23878300.0 10755500.0 True False 53091959.17350581 20315750.716884382 9642624.034041142 1.0 0.38265211970219476 0.18162117548777607 25.66199004428214 -13.151145953925923 0.16947281916435195 3.314192510454733 2.8042159037198385e-19 0.999503595301741 0.007758250860166499 8.783865658328644 0.12422705439275936 6.884763127962126 0.1626557858713941 7.060802210628833e-14 13.151145953925923 -3.314192510454733 TDQAQK(ub)AEGAGDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDQAQKAEGAGDAK 14 1 P05204 P05204 HMGN2 Non-histone chromosomal protein HMG-17 1 86562800.0 36732000.0 37143800.0 12687000.0 True False 35565962.76608022 51975513.04235812 9363894.098158384 1.0 1.461383553264244 0.2632824579991088 25.083993881852138 -6.802296756192321 1.4464982570021487 1.2538228348056397 0.24578439455518883 0.838817647695378 0.19809156736605676 0.21748300015106928 0.8981275125905009 0.10772303164176307 0.2501839549872356 1.576533646061685e-07 6.802296756192321 -1.008038440250451 down TDQAQK(ub)AEGAGDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDQAQKAEGAGDAK 14 1 P05204 P05204 HMGN2 Non-histone chromosomal protein HMG-17 1 46326500.0 18877000.0 11226000.0 16223500.0 True False 28637789.09355617 9222632.590861674 13016918.11398736 1.0 0.3220441550404767 0.4545364193954594 24.77141678157334 -9.806344365165629 6.398675830620114 1.000000014084114 0.3882902872231332 0.9660113594790163 0.054089740423298574 1.0862909909863305e-08 2.012400886374174e-09 0.052372167135330945 0.017457388654908042 1.5619086671045822e-10 9.806344365165629 -0.6117097268609809 TDQAQK(ub)AEGAGDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDQAQKAEGAGDAK 14 1 P05204 P05204 HMGN2 Non-histone chromosomal protein HMG-17 1 85604900.0 40497000.0 28002400.0 17105500.0 True False 55469835.290275 26765161.376446296 13065533.198830806 1.0 0.4825174121463234 0.23554303218061767 25.72520010580503 -9.74870243902857 0.19544639766220562 1.5687363866076596 6.219675171794568e-21 0.9994849594218376 0.007228984522830838 1.202188079613929 0.08346170973427441 0.5272185912023353 0.14755923457279713 1.7836003995753031e-10 9.74870243902857 -1.5687363866076596 TDQAQK(ub)AEGAGDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDQAQKAEGAGDAK 14 1 P05204 P05204 HMGN2 Non-histone chromosomal protein HMG-17 1 80622900.0 36732000.0 34421000.0 9469900.0 True False 30544285.503509007 34235567.240966424 11450012.306129571 1.0 1.1208501582737416 0.37486594030212833 24.864399157286414 -6.8653651477366555 1.1582424723276965 1.0667708508738871 0.3348432304524715 0.9598394123748951 0.0655151039279499 0.14138130450804254 0.3573950246598059 0.04400870790435511 0.10343922222290995 1.36343629947096e-07 6.8653651477366555 -0.7319276204214156 down TDQAQK(ub)AEGAGDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDQAQKAEGAGDAK 14 1 P05204 P05204 HMGN2 Non-histone chromosomal protein HMG-17 1 39036060.0 18877000.0 15546500.0 4612560.0 True False 24436648.62129982 14681323.608528176 3773121.4088622928 1.0 0.6007912065213162 0.15440420932244822 24.54254310366579 -7.618474516402726 0.4230127992300013 1.0347930157013752 6.038256912923713e-26 0.9981468896516308 0.014868357451067979 0.119905893540974 0.06287756522939886 0.024393994367150788 0.0726368141243023 2.4072737692801888e-08 7.618474516402726 -1.0347930157013752 down TDQVIQSLIALVNDPQPEHPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDQVIQSLIALVNDPQPEHPLR 22 0 A0A1B0GUS4;P68036-2;P68036;P68036-3 A0A1B0GUS4;P68036-2 UBE2L3 Ubiquitin-conjugating enzyme E2 L3 0 58226000.0 14243000.0 31333000.0 12650000.0 False True 21607672.302776966 25741381.34415362 10149721.95530803 1.0 1.191307466322756 0.469727688067706 24.365040329740125 -6.836207399758385 1.2999679936619393 1.1018707780769157 0.4477324037509521 0.9177204615796729 0.08755219645212434 0.1732767767385751 0.5704549543057822 0.05284264534996272 0.12163833134696649 1.4581177616893732e-07 6.836207399758385 -0.6541383743259637 down TDQVIQSLIALVNDPQPEHPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDQVIQSLIALVNDPQPEHPLR 22 0 A0A1B0GUS4;P68036-2;P68036;P68036-3 A0A1B0GUS4;P68036-2 UBE2L3 Ubiquitin-conjugating enzyme E2 L3 0 28241200.0 14243000.0 6610300.0 7387900.0 False True 18437844.271503605 6242430.994079292 6043378.006255479 1.0 0.3385662066648002 0.3277703139946654 24.136166651832575 TDTGEPMGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDTGEPMGR 9 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 4137570.0 351970.0 1922400.0 1863200.0 False True 461436.07848232833 1635585.4134565082 1670413.9370764217 1.0 3.5445546842283733 3.6200332288069967 18.815771283426603 -10.401875627456825 0.6955982115851141 7.720003441830161e-19 3.6071771972734132 0.9999059915025115 0.011806523095359097 1.7651021194628842 0.3508672164523878 3.313415773454717 0.011797920349987437 3.9639153596197717e-11 10.401875627456825 3.6071771972734132 TDTGEPMGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 TDTGEPMGR 9 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 25645680.0 8540300.0 5701280.0 11404100.0 False True 8269192.851223863 7977830.835782426 8417024.094333403 1.0 0.9647653621479738 1.0178773485839867 22.979315085375358 -6.727869109021529 1.7312127742552312 0.9787452582140173 1.017832314307787 0.5492388340959773 0.014814476087264761 0.34026007995121016 1.9969119980052898 0.006784368348081459 0.01687433212649134 1.8712460257658408e-07 6.727869109021529 0.03908705609376972 TDTGEPMGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDTGEPMGR 9 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 3206270.0 351970.0 1366900.0 1487400.0 False True 482102.8206316048 1306505.8382661645 1136106.7539645713 1.0 2.710014922863355 2.35656524986963 18.878981344949494 -10.001181267683505 5.735189884958222 0.9999971344417802 2.5332900863670824 0.9616738169981852 0.14429522476678608 5.286978548001472e-06 9.209413873685639e-07 0.13971351064442486 0.046571083537947505 9.972837264062347e-11 10.001181267683505 1.5332929519253022 TDTGEPMGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDTGEPMGR 9 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 12954000.0 7533300.0 3525300.0 1895400.0 False True 6264272.731775689 3506308.509182735 2291719.3766605747 1.0 0.559731138683808 0.36583965526209733 22.578715594886525 -13.999999999980453 0.11131596071046013 3.119661423023273 0.0167977597760934 0.9997363841791739 0.004307925861058727 12.00504020088063 0.10145605783537721 5.705409567327394 0.3099273615190076 1.0000000000450088e-14 13.999999999980453 -3.1028636632471795 TDTLEDLFPTTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDTLEDLFPTTK 12 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 12409990.0 989690.0 5282500.0 6137800.0 False True 1297493.174171594 4494371.591023724 5502719.333934987 1.0 3.4638884276930626 4.2410391387594695 20.307295518223558 -9.476223116975293 0.34743035351954765 3.430400718318661e-20 4.4366611957174555 0.9984356995730475 0.0546434765219389 0.8383035043429684 0.14041682768899966 1.2425541180938011 0.22920574447831643 3.3402339281609447e-10 9.476223116975293 4.4366611957174555 TDTLEDLFPTTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDTLEDLFPTTK 12 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 14332100.0 3207200.0 2699400.0 8425500.0 False True 3105389.1915325196 3777284.4971850347 6218608.790418019 1.0 1.2163642829325791 2.0025215542626125 21.5663426588674 -6.947084452419916 0.5899839069836603 0.9909127959290399 2.2675303514646985 0.998952177006991 0.013943400824568079 0.08467802392082464 0.04097338482492014 0.014455871098582497 0.06586009710746167 1.1295762371808373e-07 6.947084452419916 1.2766175555356587 up TDTLEDLFPTTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDTLEDLFPTTK 12 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 14634390.0 989690.0 7150900.0 6493800.0 False True 1355605.1383666035 6834949.59313594 4960098.184009095 1.0 5.041991506001159 3.658954988903051 20.37050557974645 -9.73202873855068 9.226236912089764 0.9999999953827576 4.350473247452105 0.8866854147817029 0.5646222937543977 0.0 0.0 0.5466931851520536 0.18223106171735115 1.8534089738019097e-10 9.73202873855068 3.3504732520693477 TDTLEDLFPTTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDTLEDLFPTTK 12 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 7693400.0 3207200.0 2217000.0 2269200.0 False True 2666928.9030505856 2205056.580959957 2743679.2284046514 1.0 0.8268149100029204 1.0287785419649824 21.346747934301675 -6.67973234928706 1.903128188555401 0.8903964957322427 1.0280032003221544 0.3228127760359818 0.0734043410333258 0.43909335401860217 3.074637345814222 0.03095403692510103 0.08165853503754872 2.090584136970735e-07 6.67973234928706 0.13760670458991175 TDTLEDLFPTTK(ub)IPNPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDTLEDLFPTTKIPNPR 17 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 104969400.0 20029200.0 44662200.0 40278000.0 True False 26258475.163048737 37998773.85189202 36110418.933857955 1.0 1.4471051200019558 1.3751910082224805 24.646279805172718 -10.664241240900378 6.4933052994299985 0.9972847231329752 1.411148064112218 0.9775694136153232 0.029358813194197933 0.001159746107307223 5.996864063949512e-05 0.028567141376758934 0.009475516213795259 2.1665003278936093e-11 10.664241240900378 0.4138633409792428 TDTLEDLFPTTK(ub)IPNPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDTLEDLFPTTKIPNPR 17 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 162498100.0 48794700.0 52341000.0 61362400.0 True False 47245738.95736841 73241034.25470921 45289746.607459135 1.0 1.5502145986286155 0.9585996029890814 25.49368088429068 -6.662467450170748 1.9639979870531774 1.3534463718226701 0.9610495019291749 0.2461556036632233 0.23413191859985621 0.47865338081121633 3.5517532962601503 0.09622382337590443 0.2596451571998095 2.175367068955936e-07 6.662467450170748 -0.3923968698934952 TDTLEDLFPTTK(ub)IPNPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDTLEDLFPTTKIPNPR 17 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 284495300.0 76552600.0 65042700.0 142900000.0 True False 116135890.94471417 53435322.004065424 114655752.36470489 1.0 0.4601103204994828 0.9872551149522425 26.791238654524268 -10.903561511124817 10.698464241240966 1.025684097892078 0.7236827177260553 0.26812255651533334 0.21520596116226362 0.10293922358807749 0.0009279170673893588 0.16269668977499135 0.06945742529883393 1.2486435809327345e-11 10.903561511124817 -0.30200138016602274 TDTLEDLFPTTK(ub)IPNPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDTLEDLFPTTKIPNPR 17 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 90687700.0 20029200.0 32035500.0 38623000.0 True False 27434536.508777887 30620065.682768114 29501042.865653872 1.0 1.1161138323941064 1.075324996149098 24.70948986669561 -10.391854849278474 4.81762618367674 0.9998874918377516 1.0957194142716362 0.8801348100568793 0.01665197266715243 2.0146249494422633e-05 2.543119199584334e-06 0.01614213007344009 0.005374401068431859 4.056440879275899e-11 10.391854849278474 0.09583192243388461 TDTLEDLFPTTK(ub)IPNPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDTLEDLFPTTKIPNPR 17 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 162006900.0 48794700.0 60597300.0 52614900.0 True False 40574955.02172691 60270850.31727775 63616432.32618892 1.0 1.4854200154998118 1.5678743769925034 25.274086159724956 -11.773894763519229 0.2950841448649276 8.197981308827752e-13 1.5915851943364316 0.9994205824096517 0.006030662483595533 4.5857933263558 0.16092904247805537 2.880914432657484 0.03039927408063778 1.6830818492420457e-12 11.773894763519229 1.5915851943356119 TDTLEDLFPTTK(ub)IPNPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDTLEDLFPTTKIPNPR 17 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 271220200.0 76552600.0 53097600.0 141570000.0 True False 99098849.77734374 50142671.88345841 115805712.63086785 1.0 0.5059864165539707 1.1685878583965532 26.562364976616717 -6.707095613853421 1.8054250361395803 0.6953920622702525 1.166909448885229 0.4513143964879216 0.2082723557680673 0.3809658782234699 2.4187573011915853 0.09186248586273221 0.23421112050680937 1.9629280729134906e-07 6.707095613853421 0.47151738661497644 TDTSQESK(ub)AQANCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDTSQESKAQANCR 14 1 Q9HAV4 Q9HAV4 XPO5 Exportin-5 1 8283300.0 2881500.0 2511500.0 2890300.0 True False 3777674.404485693 2136793.989750323 2591239.48171532 1.0 0.5656374162932218 0.6859351029931076 21.849066931379642 -10.332135759775646 8.497360406775702 1.0000007907452249 0.625786259643169 0.9280689185241877 0.04911132494198574 7.357290407565482e-07 5.778810301767935e-08 0.04755193650932992 0.015850611967540975 4.654405747841223e-11 10.332135759775646 -0.3742145311020558 TDTSQESK(ub)AQANCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDTSQESKAQANCR 14 1 Q9HAV4 Q9HAV4 XPO5 Exportin-5 1 2724100.0 1231200.0 0.0 1492900.0 True False 1192116.2299248085 0.0 1101864.7039600096 1.0 0.0 0.9242930146412893 20.18509347304484 -10.448649310740057 12.69306391001681 1.0000000590518685 0.4621465073206446 0.3110524079424085 0.37734104311499667 5.768027946678509e-07 2.4877195243355277e-08 0.36535893206522124 0.12178629798540976 3.559186039393685e-11 10.448649310740057 -0.537853551731224 TDTSQESK(ub)AQANCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDTSQESKAQANCR 14 1 Q9HAV4 Q9HAV4 XPO5 Exportin-5 1 28521900.0 3353400.0 2904500.0 22264000.0 True False 5087352.966378733 2386169.282037919 17863510.641342137 1.0 0.46903945879273956 3.5113566444865136 22.278483762832472 -6.861863487105253 1.1762000206541303 0.7103473984898566 3.6640702311999553 0.955870663092133 0.2787289380631959 0.14489917731587676 0.37984650909786616 0.18467566799962176 0.4320574689512184 1.3744739490273775e-07 6.861863487105253 2.9537228327100986 up TDTSQESK(ub)AQANCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDTSQESKAQANCR 14 1 Q9HAV4 Q9HAV4 XPO5 Exportin-5 1 9948500.0 2881500.0 2408500.0 4658500.0 True False 3946868.4196095397 2302084.5061555784 3558258.244819116 1.0 0.5832686224648254 0.9015396173686305 21.912276992902534 -9.773417806593274 5.9835670835811365 1.0000000117923966 0.7424041199160046 0.4662164673938647 0.12993358957628467 2.0332305455653858e-08 4.3862673729573875e-09 0.1258076627583821 0.04193588571144825 1.6849312821674107e-10 9.773417806593274 -0.257595891876392 TDTSQESK(ub)AQANCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDTSQESKAQANCR 14 1 Q9HAV4 Q9HAV4 XPO5 Exportin-5 1 6337900.0 1231200.0 1250600.0 3856100.0 True False 1023797.3514080467 1243862.769575335 4662392.681408061 1.0 1.2149501733566985 4.554019088832169 19.965498748479117 -6.920004282874683 0.8247014429784995 0.9263370104611107 5.092515688028452 0.9941819772183129 0.12410744161206205 0.09816921739636249 0.10560331610596489 0.10693361508005722 0.32032697432625834 1.202252578324656e-07 6.920004282874683 4.166178677567341 up TDTSQESK(ub)AQANCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDTSQESKAQANCR 14 1 Q9HAV4 Q9HAV4 XPO5 Exportin-5 1 22269300.0 3353400.0 2614900.0 16301000.0 True False 4341042.405396349 2469378.516318162 13334385.262384525 1.0 0.5688445966914486 3.0717012222245406 22.04961008492492 -6.862507661438711 1.1730811451158973 0.7643504027740294 3.1987896693838724 0.9566117031911698 0.227567528684756 0.14423619574352575 0.3757596766632021 0.15114897058837312 0.3538636724737223 1.3724367494800707e-07 6.862507661438711 2.434439266609843 up TDTVLILCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDTVLILCR 9 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 104113000.0 35622000.0 32703000.0 35788000.0 False True 46700786.963938735 27823839.87529555 32085001.062736623 1.0 0.5957895291310716 0.687033413109546 25.476943525482785 -10.501584788987934 5.583599530086109 1.000591078897413 0.6414114711203142 0.9536891392662843 0.03725015964949681 0.00027452361624956563 2.450501565499626e-05 0.036124666086638835 0.012022437330505491 3.1507591852763986e-11 10.501584788987934 -0.3591796077770989 TDTVLILCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDTVLILCR 9 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 33770200.0 15905000.0 7594200.0 10271000.0 False True 15400104.480956832 10626603.663229827 7580716.976604765 1.0 0.690034517387221 0.492251009464175 23.876436803030867 -8.747719824802942 0.11857856757157133 1.5403961071471046 1.7177251908612542e-05 0.9999475139449587 0.0015138997522533251 0.28843860211864464 0.03344226551476684 0.22958518423895785 0.17860583211206682 1.7876404584748492e-09 8.747719824802942 -1.540378929895196 TDTVLILCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDTVLILCR 9 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 86761000.0 35622000.0 24783000.0 26356000.0 False True 48792416.04835368 23688005.113578442 20131255.618858565 1.0 0.4854853895757783 0.4125898500067782 25.540153587005676 -13.999999999999998 0.275279455147158 5.086214288393625 0.3896047618470657 0.999594785136482 0.005262479352757847 15.148796161554472 0.1661438778386153 34.75158975458947 0.029497302302837484 1.0000000000000041e-14 13.999999999999998 -4.69660952654656 TDTVLILCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDTVLILCR 9 0 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 0 30847500.0 15905000.0 5121600.0 9820900.0 False True 13225712.210968941 5094008.924241992 11874404.783288915 1.0 0.3851595167795349 0.897827246947102 23.656842078465143 -10.200056889472638 7.768837399101963 1.0000002187102934 0.6414933818633367 0.3946805673665088 0.20929572441689828 7.926720092180261e-07 8.201495707652044e-08 0.20264983758004268 0.06754990459158867 6.308746989914763e-11 10.200056889472638 -0.3585068368469567 TDWHMAFTGMSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDWHMAFTGMSR 12 0 Q96M27;Q96M27-3;Q96M27-2 Q96M27 PRRC1 Protein PRRC1 0 10263000.0 3132000.0 2618600.0 4512400.0 False True 4106082.3303311453 2227915.0872228523 4045500.1339972317 1.0 0.542588995540958 0.9852457424230391 21.969331124284 -10.770451301824266 10.137604899033056 1.0011117061989907 0.7639173704551503 0.27497151322715385 0.18071386017690455 0.004558975705571812 0.00010322997182713044 0.1756812436237217 0.05832514757450063 1.696479820750412e-11 10.770451301824266 -0.2371943357438404 TDWHMAFTGMSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDWHMAFTGMSR 12 0 Q96M27;Q96M27-3;Q96M27-2 Q96M27 PRRC1 Protein PRRC1 0 12836300.0 4995400.0 2514100.0 5326800.0 False True 4836823.761343713 3517993.240858301 3931551.279425395 1.0 0.7273354197798952 0.8128374059949571 22.205628540792553 -10.385531881775433 8.28221877819305 1.000001872428531 0.7700864128874262 0.9060225974546876 0.0349060397035638 1.206836603319196e-06 8.957141648431314e-08 0.03379790255065245 0.01126587587116313 4.1159313093579053e-11 10.385531881775433 -0.2299154595411047 TDWHMAFTGMSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDWHMAFTGMSR 12 0 Q96M27;Q96M27-3;Q96M27-2 Q96M27 PRRC1 Protein PRRC1 0 8363900.0 3031600.0 5332300.0 0.0 False True 4599158.839647454 4380709.40354994 0.0 1.0 0.9525023066795713 0.0 22.13293859379011 -7.06330142222102 1.0339923314078445 1.0087357613744525 2.8825511237419184e-20 0.9884743631824431 0.04945075597415271 0.08461909491622731 0.17356155326058842 0.03986586200209162 0.07109145818302941 8.643677958029483e-08 7.06330142222102 -1.0087357613744525 down TDWHMAFTGMSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDWHMAFTGMSR 12 0 Q96M27;Q96M27-3;Q96M27-2 Q96M27 PRRC1 Protein PRRC1 0 10536900.0 3132000.0 3091000.0 4313900.0 False True 4289985.039117502 2954429.399429891 3295045.667559342 1.0 0.6886805833797616 0.7680785917699073 22.032541185806892 -9.792857210615596 5.862080956824002 1.0000000227820944 0.728379587573869 0.9397746396307808 0.03241410119494023 9.646766383966184e-09 1.9944723123912416e-09 0.03138482133208757 0.010461606175356346 1.611175277897513e-10 9.792857210615596 -0.27162043520822543 TDWHMAFTGMSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDWHMAFTGMSR 12 0 Q96M27;Q96M27-3;Q96M27-2 Q96M27 PRRC1 Protein PRRC1 0 9802700.0 4995400.0 2312800.0 2494500.0 False True 4153896.433742487 2300340.4873451423 3016088.4167351522 1.0 0.5537789697064334 0.7260865707279521 21.98603381622683 -10.090556735881368 5.113995663114232 1.000008044419107 0.6399327702163327 0.8534225801243346 0.07034428355395819 6.452007585974554e-06 1.147351724080362e-06 0.06811208044289714 0.02270351989168454 8.117891905220369e-11 10.090556735881368 -0.3600752742027744 TDWHMAFTGMSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDWHMAFTGMSR 12 0 Q96M27;Q96M27-3;Q96M27-2 Q96M27 PRRC1 Protein PRRC1 0 15927400.0 3031600.0 6348100.0 6547700.0 False True 3924465.961770017 5994822.654571617 5356085.785075455 1.0 1.5275511911607522 1.364793538089383 21.90406491588256 -10.029445111551766 4.83443389668002 0.999991257909479 1.4461723645602147 0.9092546649755884 0.06644553365469338 45928734.97964978 3.9164325576818553 4635.175351534022 0.02274607351330175 9.344474612384644e-11 10.029445111551766 0.44618110665073574 TDYIPLLDVDEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDYIPLLDVDEK 12 0 P27816-6;P27816;E7EVA0;P27816-2;P27816-5;H7C456;A0A0J9YVV8;A0A0J9YW37;P27816-7 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 10344400.0 1189400.0 4200500.0 4954500.0 False True 1559314.9181659827 3573801.77342076 4441855.8669198835 1.0 2.2919050743285094 2.8485944790063673 20.5724808924818 -9.559540802596057 0.2387686619534455 9.770972310516776e-19 3.2228276658087185 0.9991769218990144 0.02221489234643947 0.9707169456878618 0.09708020379507269 0.9738697786153655 0.25893198653067323 2.7571424026524703e-10 9.559540802596057 3.2228276658087185 TDYIPLLDVDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDYIPLLDVDEK 12 0 P27816-6;P27816;E7EVA0;P27816-2;P27816-5;H7C456;A0A0J9YVV8;A0A0J9YW37;P27816-7 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 8671300.0 1189400.0 3768600.0 3713300.0 False True 1629153.322326421 3602090.790906334 2836295.0178140644 1.0 2.2110201302370793 1.7409626085799292 20.63569095400469 -10.292973273359758 5.201008627676187 0.9997947921970566 1.9759913694086397 0.8518114072220285 0.1919001796366846 0.00045671692308174236 6.208681879646344e-05 0.18584447402252102 0.06193551665552286 5.093622164285877e-11 10.292973273359758 0.9761965772115831 TDYIPLLDVDEK(ub)TGNSESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDYIPLLDVDEKTGNSESK 19 1 P27816-6;P27816;E7EVA0;P27816-2;P27816-5;H7C456;A0A0J9YVV8;A0A0J9YW37;P27816-7 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 1 7250300.0 2419300.0 3094800.0 1736200.0 True False 3171725.728534528 2633067.903435916 1556554.6788064004 1.0 0.8301688509026616 0.49075954607386396 21.59683659030584 -6.960059729785723 0.43459592444551787 1.0128427691326107 0.29497068726878745 0.9997723953805794 0.003193881709878618 0.07967985822866837 0.02105295910868459 0.004446738521240896 0.028152696292086398 1.0963274046711315e-07 6.960059729785723 -0.7178720818638233 down TDYMVGSYGPR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TDYMVGSYGPR 11 0 P52565;J3KTF8;J3QQX2;J3KRE2 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 0 27414890.0 5641290.0 11613900.0 10159700.0 False True 7395785.8203300685 9881151.390627619 9108471.70272398 1.0 1.33605158811733 1.2315759168803884 22.818272014669063 -10.100674656157457 4.32027483906904 0.999965846633022 1.2838137524946727 0.9077452516460974 0.04265201430565151 29691470.965806045 0.6837284444264962 10915.797821137216 0.014600918954606768 7.930952409244614e-11 10.100674656157457 0.28384790586165065 TDYMVGSYGPR ddPTM_RPMI8226_Bortezomib_2h_R1 2 TDYMVGSYGPR 11 0 P52565;J3KTF8;J3QQX2;J3KRE2 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 0 19810610.0 6204800.0 4467010.0 9138800.0 False True 6007832.020335807 6250710.388149408 6745074.121876708 1.0 1.0404269571771456 1.122713501150735 22.518413044823422 -6.9596998592795085 0.4396436812882541 0.997046828811205 1.1692999632184116 0.9997588915375891 0.0007928200906952118 0.07980849039904578 0.02152881567332605 0.0010844207214412828 0.006818414119036909 1.097236233639328e-07 6.9596998592795085 0.17225313440720658 TDYMVGSYGPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDYMVGSYGPR 11 0 P52565;J3KTF8;J3QQX2;J3KRE2 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 0 26353400.0 0.0 22469000.0 3884400.0 False True 0.0 18459231.39890171 3116646.6374069983 0.0 TDYMVGSYGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TDYMVGSYGPR 11 0 P52565;J3KTF8;J3QQX2;J3KRE2 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 0 24239790.0 5641290.0 8640200.0 9958300.0 False True 7727027.36313 8258447.394679439 7606354.637626319 1.0 1.0687741878701171 0.9843830337550662 22.881482076191954 -6.689993366086236 1.8662075901075486 1.0431166993751928 0.9846728628635603 0.37049501663363726 0.029086592889662075 0.41668528357594786 2.8135637909545617 0.01246790527241877 0.032470337366157905 2.0417691327630158e-07 6.689993366086236 -0.05844383651163254 TDYMVGSYGPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDYMVGSYGPR 11 0 P52565;J3KTF8;J3QQX2;J3KRE2 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 0 12522900.0 5025800.0 4792100.0 2705000.0 False True 4179175.380690836 4766284.006142626 3270602.993493116 1.0 1.1404843233343172 0.7825952958577371 21.994786872503234 -6.800212344170391 1.4549240053628572 1.0774895624408936 0.7776216096936456 0.8328301509259075 0.06019631243135592 0.2204456114915767 0.9212221337093999 0.03254787328737688 0.07568868650540671 1.5841184633710013e-07 6.800212344170391 -0.299867952747248 TDYMVGSYGPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDYMVGSYGPR 11 0 P52565;J3KTF8;J3QQX2;J3KRE2 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 0 10164400.0 0.0 6359700.0 3804700.0 False True 0.0 6005777.104374396 3112283.6395187047 0.0 TDYNASVSVPDSSGPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDYNASVSVPDSSGPER 17 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 263525000.0 50993000.0 128100000.0 84432000.0 False True 66852316.81691447 108987979.329889 75695786.56893319 1.0 1.6302797646993992 1.1322836690348062 25.994474223069503 -10.091209039301384 4.46339100703538 0.999971035552649 1.3812817163959799 0.4387035316073835 0.20330605480172273 141395407.14050427 2.627389625881844 48670.79132906728 0.06959707016926071 8.10570811262331e-11 10.091209039301384 0.38131068084333086 TDYNASVSVPDSSGPER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDYNASVSVPDSSGPER 17 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 197586000.0 70079000.0 23817000.0 103690000.0 False True 67854380.50430527 33327252.30401419 76530478.36667779 1.0 0.4911584492603189 1.1278634894002464 26.01593861954381 -6.693924479375376 1.8531572156140061 0.6821578998747843 1.1257315676173871 0.38858334538343153 0.21503698553337883 0.40826513468103914 2.7214664889965317 0.09274003080093844 0.24025272126343228 2.0233709974619988e-07 6.693924479375376 0.4435736677426029 TDYNASVSVPDSSGPER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TDYNASVSVPDSSGPER 17 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 370692000.0 52198000.0 273970000.0 44524000.0 False True 79188182.18495756 225077912.96261987 35723811.88443754 1.0 2.8423169562967345 0.45112554548857375 26.23878180694948 -6.7008710145618595 1.8275340226573893 2.142950248742704 0.45801629083894585 0.4219868463563534 0.777528019325951 0.3936150535408582 2.5563727132785026 0.3393251781791156 0.871792067572099 1.9912646566698243e-07 6.7008710145618595 -1.6849339579037583 TDYNASVSVPDSSGPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDYNASVSVPDSSGPER 17 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 230934000.0 50993000.0 85214000.0 94727000.0 False True 69846490.13400984 81448963.71498501 72354433.56380382 1.0 1.166113910072135 1.0359065061820882 26.057684284592394 -10.140014521722657 5.354255842680881 0.9999974894420159 1.1010102081271524 0.44518817058980586 0.053156950043992894 1.5931197644032418e-06 2.5584075539686456e-07 0.05147027481573864 0.0171563318546096 7.244117371510225e-11 10.140014521722657 0.1010127186851365 TDYNASVSVPDSSGPER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TDYNASVSVPDSSGPER 17 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 141422000.0 70079000.0 45779000.0 25564000.0 False True 58273793.52609203 45532379.44058001 30909314.20541889 1.0 0.7813525889676796 0.5304153434181229 25.796343894978087 -6.9693247996937275 0.27384014362212766 1.0595475844988895 0.244637509007743 0.9999766229949039 0.0009276118167966219 0.07652246561540864 0.009811996199202188 0.004805898694473059 0.023217545483559268 1.0731864985640781e-07 6.9693247996937275 -0.8149100754911465 TDYNASVSVPDSSGPER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TDYNASVSVPDSSGPER 17 0 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 0 177412000.0 52198000.0 74296000.0 50918000.0 False True 67571339.97640552 70161362.28856711 41651446.4627995 1.0 1.0383301901821982 0.6164069926294684 26.00990812904193 -6.8847042474377655 1.0531688477782843 1.0256309991558783 0.5836658383314248 0.9772879146345856 0.028710225041175583 0.1235466226786273 0.24777291232952495 0.020901891344340486 0.05120982030479552 1.3040545313308318e-07 6.8847042474377655 -0.4419651608244535 TDYYAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TDYYAR 6 0 P46777;A0A2R8Y4A2;R4GNJ2 P46777 RPL5 60S ribosomal protein L5 0 18001300.0 4191700.0 8580100.0 5229500.0 False True 5495359.292480537 7299982.524967857 4688401.504906151 1.0 1.3283903993241424 0.8531565008536258 22.38978237853042 -6.720804006888159 1.7563787125385855 1.199617327490707 0.8538618576559756 0.5163136249212165 0.13817454297844828 0.3537656254119517 2.1332170638539867 0.0624540715738413 0.15663758270769937 1.9019364127138333e-07 6.720804006888159 -0.3457554698347314 TDYYAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TDYYAR 6 0 P46777;A0A2R8Y4A2;R4GNJ2 P46777 RPL5 60S ribosomal protein L5 0 9288900.0 4044500.0 218700.0 5025700.0 False True 3916109.5613473654 306028.0505054334 3709318.402231775 1.0 0.07814593685681824 0.9471947462459548 21.900989697238565 -9.109101688499292 12.331635953808949 1.000000000338928 0.5126703445062526 0.29541353079229193 0.3547876907627747 0.0 0.0 0.3435217044409015 0.11450723481363381 7.778543978908131e-10 9.109101688499292 -0.4873296558326754 TDYYAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TDYYAR 6 0 P46777;A0A2R8Y4A2;R4GNJ2 P46777 RPL5 60S ribosomal protein L5 0 15986200.0 4191700.0 6709300.0 5085200.0 False True 5741484.766433209 6412860.94131186 3884180.4929814637 1.0 1.1169342430034404 0.676511503729799 22.45299244005331 -6.836105586544595 1.3004943449164816 1.0622689457378685 0.6631193175266705 0.9175228829535315 0.05349644767162842 0.17339986683042644 0.5713731145312794 0.032275981902583954 0.0742924614646058 1.4584596335400304e-07 6.836105586544595 -0.3991496282111979 TEADAEK(ub)TFEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEADAEKTFEEK 12 1 P19338;H7BY16 P19338 NCL Nucleolin 1 6565200.0 2041000.0 2278000.0 2246200.0 True False 3096346.2170868358 1871473.1019047622 1802237.585455566 1.0 0.6044133861960429 0.5820529937867162 21.562135364368604 -13.999999999999998 0.4091575320681972 8.073613627901887 0.5810168441175989 0.9998503123626988 0.00234867261842061 28.170772282073806 0.21193071453627854 177.49922387155368 0.005581112188394064 1.0000000000000041e-14 13.999999999999998 -7.492596783784288 TEADAEK(ub)TFEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEADAEKTFEEK 12 1 P19338;H7BY16 P19338 NCL Nucleolin 1 6336800.0 2041000.0 1802300.0 2493500.0 True False 2642114.7341247536 1702000.4206509704 2039708.5854705696 1.0 0.6441811169925546 0.771998490120929 21.333261686461054 -10.540084815370593 7.071554376509149 1.000163280389799 0.7080898035567418 0.8742828636161688 0.052181224071240546 0.0001344017136087971 8.741081570043504e-06 0.05055215611860936 0.016841417651052674 2.883468322319669e-11 10.540084815370593 -0.2920734768330573 TEAEQCK(ub)NLELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEAEQCKNLELK 12 1 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 1 23837210.0 8393210.0 9028500.0 6415500.0 True False 11003579.589961253 7681482.9928173665 5751685.601821472 1.0 0.698089465343197 0.522710410262205 23.391469589470436 -10.77150938780856 0.09114465055027805 1.9528457852630905 1.7900075440938276e-13 0.9999287381352344 0.0016640282533699772 2.8943571401160666 0.05265002482942557 0.9102496802795244 0.32151290033549706 1.692351661781573e-11 10.77150938780856 -1.9528457852629115 TEAEQCK(ub)NLELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEAEQCKNLELK 12 1 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 1 12021600.0 5360900.0 3566100.0 3094600.0 True False 5190721.163908301 4990062.32696583 2284031.4239899814 1.0 0.9613427825139838 0.4400219838181874 22.307503560184088 -6.921779253541937 0.811423553570318 1.0107817517058981 0.3524153990968656 0.9946609840352857 0.01865825775490394 0.09713627977250307 0.10027296344211799 0.01622931813091382 0.049472955241968875 1.1973489741832954e-07 6.921779253541937 -0.6583663526090325 down TEAEQCK(ub)NLELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEAEQCKNLELK 12 1 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 1 34136200.0 3996200.0 15741000.0 14399000.0 True False 6062527.561353453 12931895.565005654 11553031.338694112 1.0 2.1330864782276753 1.9056459903523983 22.531487970280384 -10.175347721164481 4.549350109547712 0.999819772719206 2.0193662343045675 0.9640071217934427 0.09285219041042121 0.00017010490632139917 3.0834693014113086e-05 0.08991934202547947 0.02996791558573206 6.678090171163709e-11 10.175347721164481 1.0195464615853616 TEAEQCK(ub)NLELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEAEQCKNLELK 12 1 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 1 22991920.0 8393210.0 9681600.0 4917110.0 True False 11496406.554971706 9253834.899230173 3755789.8890592474 1.0 0.8049328157439146 0.32669250788064974 23.454679650993327 -6.955879045442712 0.49007772241171915 1.0104585623116082 0.10088472380545352 0.9995854965804002 0.005758924660720165 0.08120748591149851 0.02683136853292524 0.006886802954275948 0.039443799488902365 1.1069320306547675e-07 6.955879045442712 -0.9095738385061547 down TEAEQCK(ub)NLELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEAEQCKNLELK 12 1 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 1 17328560.0 5360900.0 6929700.0 5037960.0 True False 4457825.878137908 6892368.330662239 6091374.143104842 1.0 1.546127758031965 1.3664450585605394 22.087908835618364 -10.366139475615231 6.010874618845017 0.9999293429715335 1.4562864082962053 0.8958124506478478 0.07335515488514269 6.94733339109963e-05 7.326118341308863e-06 0.07103675389899808 0.023675274435718433 4.303883671451577e-11 10.366139475615231 0.4563570653246718 TEAEQCK(ub)NLELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEAEQCKNLELK 12 1 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 1 52705500.0 3996200.0 28658500.0 20050800.0 True False 5173159.676878652 27063629.28215382 16401760.138581645 1.0 5.23154725014854 3.170549753545987 22.302614292372834 -9.109707090808856 11.147895167658929 1.0000000000126912 4.201048501950604 0.7628301276677262 0.8413987046388499 0.0 0.0 0.8146807926464388 0.2715602642154796 7.767708317952629e-10 9.109707090808856 3.2010485019379127 TECCSDAGDSPLK(ub)PVSCPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TECCSDAGDSPLKPVSCPK 19 1 Q96M89-2;Q96M89;H7C005 Q96M89-2 CCDC138 Coiled-coil domain-containing protein 138 1 31176400.0 2088400.0 11541000.0 17547000.0 True False 3168255.482491007 9481418.379755419 14078827.758876694 1.0 2.992630623430897 4.443716056574884 21.59525724579645 -7.94954119915442 0.22762774716172254 3.039090843649181e-20 6.0080873615774095 0.9997370565351038 0.02289104022132332 0.11212339765038244 0.040222025605564656 0.34662521039421307 0.49901621056368833 1.1232044123291156e-08 7.94954119915442 6.0080873615774095 TECCSDAGDSPLK(ub)PVSCPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TECCSDAGDSPLKPVSCPK 19 1 Q96M89-2;Q96M89;H7C005 Q96M89-2 CCDC138 Coiled-coil domain-containing protein 138 1 21904500.0 2088400.0 13011000.0 6805100.0 True False 2703474.9685184387 12286926.41241181 5566641.626222488 1.0 4.544864130606434 2.059069046706626 21.3663835678889 -6.553564556313902 2.3717848606381935 3.4510272568077913 2.0621390025142015 0.0 1.5502362529739373 0.7827065949135916 8.243554888105308 0.5583937555761972 1.7490467656216537 2.795345178682191e-07 6.553564556313902 -1.3888882542935899 TECNHYNNIMALYLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TECNHYNNIMALYLK 15 0 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 0 47056000.0 13267000.0 16373000.0 17416000.0 False True 17393165.477810767 13930212.221454132 15613959.386068547 1.0 0.8009014942809302 0.8977065966507344 24.052017184753918 -10.101207229274388 4.524038342863351 1.000012604519605 0.8493040454605594 0.7636527710183418 0.03952051757031791 55025967.57048283 0.3148674341508629 7417.139049834504 0.013528924345526475 7.921232683437821e-11 10.101207229274388 -0.15070855905904557 TECNHYNNIMALYLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TECNHYNNIMALYLK 15 0 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 0 18403900.0 10227000.0 3300700.0 4876200.0 False True 9902349.482976777 4618686.722923108 3598976.9371356433 1.0 0.46642332012853477 0.36344677021576327 23.239339436465094 -13.999999999999991 0.23130810436217095 4.38883091078307 0.3139978069404754 0.9995116079099108 0.006165516939159739 13.3323847550975 0.15227262175370465 20.76563553337867 0.05302251744043786 1.0000000000000205e-14 13.999999999999991 -4.074833103842595 TECNHYNNIMALYLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TECNHYNNIMALYLK 15 0 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 0 53502000.0 11259000.0 26143000.0 16100000.0 False True 17080726.143155623 21477577.393808708 12917827.94311933 1.0 1.2574159443692583 0.7562809587164772 24.025865972944015 -6.767087846160024 1.5855506448181875 1.1481993566885764 0.7537657457472077 0.7192751105363224 0.10841106779064624 0.2711867494703876 1.3450009498467077 0.05390807588153872 0.12867210162703474 1.7096694597001653e-07 6.767087846160024 -0.39443361094136875 TECNHYNNIMALYLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TECNHYNNIMALYLK 15 0 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 0 58520000.0 13267000.0 20070000.0 25183000.0 False True 18172168.4271941 19183241.037385274 19235294.06016522 1.0 1.055638522955694 1.0585029594696131 24.11522724627681 TECNHYNNIMALYLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TECNHYNNIMALYLK 15 0 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 0 21039100.0 10227000.0 2224700.0 8587400.0 False True 8504203.632919174 2212715.0995316254 10382985.63634854 1.0 0.26019074742829074 1.2209239200431106 23.01974471189937 -6.701014427818669 1.8270989349615971 0.5410703493001144 1.2181357362435463 0.4224618917392524 0.3122245263814111 0.39341703125144684 2.5539868651966224 0.1362879305576795 0.35007826186941304 1.990607207368916e-07 6.701014427818669 0.6770653869434319 TECNHYNNIMALYLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TECNHYNNIMALYLK 15 0 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 0 48745000.0 11259000.0 21090000.0 16396000.0 False True 14574997.448069844 19916322.96040001 13412096.237166828 1.0 1.3664717974298866 0.920212595916645 23.796992295036464 -6.688458482562379 1.8716160702094817 1.2300793787245556 0.9217701790084482 0.3633723857438079 0.15503961436636282 0.41997451189880847 2.8510095570019214 0.06629451817728413 0.1729893906221077 2.0489979195362998e-07 6.688458482562379 -0.3083091997161075 TEDDLVPTAPSLGTKEGYLTK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEDDLVPTAPSLGTKEGYLTK 21 1 Q9UN19;J3KNB3;Q9UN19-2 Q9UN19 DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 1 12569200.0 3120800.0 3542800.0 5905600.0 True False 4091399.0218701893 3014228.049726241 5294545.1625153 1.0 0.7367230704250473 1.294067172185799 21.96416281513016 -6.778291253082914 1.542911345574574 0.8505924886859763 1.2982177592945852 0.761158303870266 0.11125605423945494 0.2532443977941616 1.1907216246644767 0.0568050348831856 0.13420737743878342 1.666129473044505e-07 6.778291253082914 0.4476252706086089 TEDDLVPTAPSLGTKEGYLTK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEDDLVPTAPSLGTKEGYLTK 21 1 Q9UN19;J3KNB3;Q9UN19-2 Q9UN19 DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 1 173149500.0 6354500.0 16585000.0 150210000.0 True False 9640241.076177496 13625277.170803541 120520927.66061811 1.0 1.4133751493490838 12.501858273901851 23.20063779410482 -6.914782875649922 0.8625211107565703 0.706401164146774 14.091773230595797 0.9926049523088466 0.4581155710787214 0.10133965367318484 0.12223718528947251 0.38417162497584345 1.099165138839346 1.2167941815602675e-07 6.914782875649922 13.385372066449023 up TEDDLVPTAPSLGTKEGYLTK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEDDLVPTAPSLGTKEGYLTK 21 1 Q9UN19;J3KNB3;Q9UN19-2 Q9UN19 DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 1 16986100.0 3120800.0 5544000.0 8321300.0 True False 4274644.096448882 5299047.748443644 6355980.322553037 1.0 1.2396465363855145 1.4869028108873916 22.02737287665305 -6.9707334309575275 0.24002491977800883 0.9112446995313801 1.8224563640714035 0.9999875501661313 0.0007013768073995839 0.07606542851056736 0.008173961126291361 0.005909312418386681 0.024103875446201854 1.06971126428948e-07 6.9707334309575275 0.9112116645400234 TEDEVLTSK(ub)GDAWAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEDEVLTSKGDAWAK 15 1 Q9BQ61 Q9BQ61 C19orf43 Uncharacterized protein C19orf43 1 11199400.0 4563000.0 3597900.0 3038500.0 True False 4418150.062659923 5034560.2328006355 2242625.696953909 1.0 1.1395177079543573 0.507593826635157 22.075010990049645 -6.84880781607119 1.2408183718097106 1.0743827379048794 0.4829052691900035 0.9385552641209773 0.06719023615048263 0.1587722809586733 0.4710043621567513 0.04238496638177488 0.09801029996724696 1.4164204354511612e-07 6.84880781607119 -0.5914774687148758 TEDEVLTSK(ub)GDAWAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEDEVLTSKGDAWAK 15 1 Q9BQ61 Q9BQ61 C19orf43 Uncharacterized protein C19orf43 1 7613200.0 3194500.0 2855900.0 1562800.0 True False 4375592.978116496 2729716.894801624 1193698.8268763134 1.0 0.6238507348498054 0.2728084702682171 22.061047112810364 -7.5641062380758735 0.29560154543743716 1.09564216914099 7.956300759199705e-12 0.9996653366422071 0.0054320441252439945 0.12627552551516158 0.033993331428313005 0.026654544722952006 0.06956429296212147 2.728310295876668e-08 7.5641062380758735 -1.0956421691330338 down TEDEVLTSK(ub)GDAWAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEDEVLTSKGDAWAK 15 1 Q9BQ61 Q9BQ61 C19orf43 Uncharacterized protein C19orf43 1 12923200.0 4563000.0 5779200.0 2581000.0 True False 3794336.675174556 5748066.3025186155 3120675.1668043407 1.0 1.5149067662147242 0.8224560533128694 21.85541626548392 -6.707579919551627 1.803741411049793 1.317330209473454 0.8241894240756109 0.453647609896235 0.21706253569066658 0.3799580188228593 2.4081795866440503 0.0958189404161893 0.2441504105610703 1.960740323765576e-07 6.707579919551627 -0.4931407853978431 TEDEVLTSK(ub)GDAWAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEDEVLTSKGDAWAK 15 1 Q9BQ61 Q9BQ61 C19orf43 Uncharacterized protein C19orf43 1 15289600.0 6750300.0 5237000.0 3302300.0 True False 8738396.418305894 4945556.34630701 2701315.2844593828 1.0 0.5659569684829887 0.3091316936366552 23.058937124608644 -8.827340735395998 0.18812264178137472 1.3895888088912376 1.7642095440946863e-22 0.9996973430897291 0.004960276764716764 0.3416400748542128 0.056680458015436606 0.2205625908281322 0.14115229085279196 1.4881930246197574e-09 8.827340735395998 -1.3895888088912376 down TEDHEEAGPLPTK(ub)VNLAHSEI ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEDHEEAGPLPTKVNLAHSEI 21 1 Q9BXS4;Q5T6Z8 Q9BXS4 TMEM59 Transmembrane protein 59 1 236844000.0 76616000.0 83552000.0 76676000.0 True False 100444317.9503995 71086367.2831451 68742303.04812774 1.0 0.7077191496113132 0.6843821975283205 26.581820713447474 -13.999999999999998 0.3582963990406398 4.783931874993544 0.6815033896529886 0.9997701909629244 0.0021768820764045222 21.5146323540803 0.19331800377107775 62.20218580865257 0.006771961780700075 1.0000000000000041e-14 13.999999999999998 -4.102428485340556 TEDHEEAGPLPTK(ub)VNLAHSEI ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEDHEEAGPLPTKVNLAHSEI 21 1 Q9BXS4;Q5T6Z8 Q9BXS4 TMEM59 Transmembrane protein 59 1 195316000.0 63821000.0 85522000.0 45973000.0 True False 61795037.288849205 119671380.59133817 33931292.139562964 1.0 1.93658561984447 0.5490941283999484 25.880987645282076 -6.7248833913753225 1.7418861718652845 1.5668190974446303 0.550659982170919 0.5353992822861144 0.3939011630428896 0.3459106807251217 2.053678136761243 0.1793829151806537 0.44772821604268914 1.8841549195880645e-07 6.7248833913753225 -1.0161591152737113 TEDHEEAGPLPTK(ub)VNLAHSEI ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEDHEEAGPLPTKVNLAHSEI 21 1 Q9BXS4;Q5T6Z8 Q9BXS4 TMEM59 Transmembrane protein 59 1 206611900.0 76616000.0 80340000.0 49655900.0 True False 104943005.66954878 76790313.15114766 37928199.11536189 1.0 0.7317335029735083 0.3614171223072514 26.645030774970365 -6.966601168594364 0.32941633248497554 1.045424469012254 0.035613889881559835 0.9999424479990178 0.00198614393038064 0.07742172437068225 0.012966352056161035 0.0054147930962216 0.0323150548134862 1.0799380207749683e-07 6.966601168594364 -1.0098105791306942 down TEDHEEAGPLPTK(ub)VNLAHSEI ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEDHEEAGPLPTKVNLAHSEI 21 1 Q9BXS4;Q5T6Z8 Q9BXS4 TMEM59 Transmembrane protein 59 1 161292700.0 63821000.0 78091000.0 19380700.0 True False 53069989.24968559 77670308.28315009 23433114.76376784 1.0 1.4635448279012087 0.4415511496246754 25.661392920716352 -6.783415967604634 1.522794627618265 1.261308834532864 0.43260420800300137 0.7792123856178708 0.19632844032678004 0.24530479076397593 1.1237770425585933 0.10152853523636578 0.2388664310296242 1.6465845360154103e-07 6.783415967604634 -0.8287046265298627 down TEDIHLFQQQVK(ub)EDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEDIHLFQQQVKEDK 15 1 Q5JPI3;Q5JPI3-2 Q5JPI3 C3orf38 Uncharacterized protein C3orf38 1 33153200.0 6269400.0 10501800.0 16382000.0 True False 6070381.328696056 14695223.506163534 12091062.75053445 1.0 2.420807311839853 1.991812720788607 22.533355715745664 -10.56812400036718 5.413492307666377 0.9944601050192403 2.206310016314232 0.9133653617214551 0.1751363084149214 0.011707609665430956 0.0009340049398130118 0.1695403463399087 0.05652500048393546 2.703186436345504e-11 10.56812400036718 1.2118499112949916 TEDIHLFQQQVK(ub)EDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEDIHLFQQQVKEDK 15 1 Q5JPI3;Q5JPI3-2 Q5JPI3 C3orf38 Uncharacterized protein C3orf38 1 34264100.0 8929700.0 6673500.0 18660900.0 True False 13547007.748515593 5482561.7847065125 14972564.93563698 1.0 0.4047064773626679 1.1052304105515547 23.691470889731654 -6.681579149765268 1.8964430609361766 0.6238860238950964 1.102588763881217 0.3313324992865525 0.25221261080441304 0.4350008451741135 3.026159422117941 0.10666575948607646 0.28073879558556664 2.0817129803923635e-07 6.681579149765268 0.4787027399861207 TEDIHLFQQQVK(ub)EDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEDIHLFQQQVKEDK 15 1 Q5JPI3;Q5JPI3-2 Q5JPI3 C3orf38 Uncharacterized protein C3orf38 1 17925200.0 3248800.0 2702500.0 11973900.0 True False 4449969.155518819 2583094.614027588 9145911.430211361 1.0 0.5804747232515204 2.0552752413730038 22.085363905552814 -6.830693152154627 1.3248447546955822 0.7759451448177519 2.095518064415957 0.9072553246562631 0.1889524542813932 0.17995102613776698 0.6174863163309413 0.11197516394263356 0.25767742462996734 1.476749552227848e-07 6.830693152154627 1.3195729195982049 up TEDIHLFQQQVK(ub)EDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEDIHLFQQQVKEDK 15 1 Q5JPI3;Q5JPI3-2 Q5JPI3 C3orf38 Uncharacterized protein C3orf38 1 23609900.0 6269400.0 8994300.0 8346200.0 True False 5213283.881512021 8945845.920671232 10091351.83153134 1.0 1.7159713769656924 1.9356996589651516 22.31376099117994 -10.890657765025638 0.2328705045711669 4.339993944539382e-11 2.062989268162291 0.9992552001599615 0.010902864426944738 2.808321242643987 0.12370934123608238 1.6417523175106148 0.11057347358589946 1.2862998973327919e-11 10.890657765025638 2.062989268118891 TEDIHLFQQQVK(ub)EDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEDIHLFQQQVKEDK 15 1 Q5JPI3;Q5JPI3-2 Q5JPI3 C3orf38 Uncharacterized protein C3orf38 1 33264700.0 8929700.0 12511500.0 11823500.0 True False 11559672.68070251 11815224.026507584 9671744.319354838 1.0 1.022107143762962 0.8366797734247837 23.462597211824104 -6.877140311093486 1.0956628200047416 1.0132449830385073 0.824240516421393 0.9713028621874878 0.014008649387043737 0.13019144810440106 0.2878719521268196 0.009873265717309676 0.023711229161823298 1.3269656747438022e-07 6.877140311093486 -0.18900446661711434 TEDLEATSEHFK(ub)TTSQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEDLEATSEHFKTTSQK 17 1 Q9BV40;C9JXZ5 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 32800400.0 16638800.0 10878000.0 5283600.0 True False 21813627.93036839 9255044.802111885 4736903.7558699995 1.0 0.42427810869677673 0.21715341304026736 24.378726395762015 -12.888082006865108 0.157686811597472 2.98398396135154 1.9445296432548487e-24 0.9995471679398038 0.007047756348431872 7.904210633534938 0.11590311878492704 5.064198782346386 0.1866686783966119 1.2939514843871592e-13 12.888082006865108 -2.98398396135154 TEDLEATSEHFK(ub)TTSQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEDLEATSEHFKTTSQK 17 1 Q9BV40;C9JXZ5 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 28317200.0 8613800.0 9223500.0 10479900.0 True False 8340359.633955742 12906491.649917075 7734899.799739089 1.0 1.547474235687804 0.9274060279425277 22.991678162938737 -6.673595292474251 1.9243485396511615 1.3483546920960046 0.9298519180167176 0.29522443661637954 0.23236236580055922 0.4528939393121442 3.236581768412979 0.09708557699985168 0.25820472907330233 2.1203360999530987e-07 6.673595292474251 -0.41850277407928693 TEDLEATSEHFK(ub)TTSQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEDLEATSEHFKTTSQK 17 1 Q9BV40;C9JXZ5 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 49281700.0 9409700.0 21999000.0 17873000.0 True False 14275202.841216056 18073106.5710285 14340393.715985822 1.0 1.2660490202525847 1.004566721432605 23.76700790969019 -10.70425885452916 2.625422089704641 0.9773656247086792 1.1353078705279462 0.2630945607143781 0.10674970664083017 17553713.138616048 15003102.407061733 2632694.731598439 0.039039927039013454 1.975791648939163e-11 10.70425885452916 0.15794224581926708 TEDLEATSEHFK(ub)TTSQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEDLEATSEHFKTTSQK 17 1 Q9BV40;C9JXZ5 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 34558700.0 16638800.0 10137300.0 7782600.0 True False 22790614.00666291 9689400.566431783 5944510.167678275 1.0 0.42514872848967805 0.2608315057216264 24.441936457284907 -13.99999999999992 0.1756315780139415 3.9442012110557023 0.12424541309828802 0.9995040630030246 0.00705722292089738 12.151313633941399 0.13280413477513775 12.197811757526507 0.12739626587584035 1.0000000000001841e-14 13.99999999999992 -3.819955797957414 TEDLEATSEHFK(ub)TTSQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEDLEATSEHFKTTSQK 17 1 Q9BV40;C9JXZ5 Q9BV40 VAMP8 Vesicle-associated membrane protein 8 1 31026100.0 8613800.0 14963000.0 7449300.0 True False 7162756.356041771 14882391.349077025 9006914.188328385 1.0 2.0777464162275683 1.2574648278704985 22.772083438373013 -10.203925644920774 4.529778165749129 0.9998456449727597 1.6676056220551156 0.4689853531468099 0.33487855623453733 235502981.12501362 123.1414289917894 406220.46529241727 0.11463783703262014 6.252797370660646e-11 10.203925644920774 0.6677599770823559 TEDPLLSWADFTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEDPLLSWADFTKR 14 1 A0A494C164;P52630-4;P52630 A0A494C164 STAT2 Signal transducer and activator of transcription 2 1 5803750.0 705850.0 1918900.0 3179000.0 True False 683443.1781127565 2685126.776931303 2346324.532044256 1.0 3.928822267779375 3.4330937921179348 19.382461870698812 -9.317951069865511 8.408936691119493 0.9999969544638799 3.6809580299511397 0.9749981156179132 0.20238030273972826 64983104.94198185 0.0 0.19595388552033274 0.06928016062563984 4.808935256506634e-10 9.317951069865511 2.68096107548726 TEDPLLSWADFTK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEDPLLSWADFTKR 14 1 A0A494C164;P52630-4;P52630 A0A494C164 STAT2 Signal transducer and activator of transcription 2 1 5883350.0 705850.0 2496600.0 2680900.0 True False 586945.5494569278 2483150.3202637006 3241463.7949189274 1.0 4.230631482871348 5.522597109592357 19.162867146133088 -9.054758193634484 0.34758069546479037 8.372143133832959e-20 5.900502041541728 0.9981336735295328 0.08217032678649891 0.5010333703105875 0.1255762367123663 1.066929991967642 0.3754821520986388 8.815395597535009e-10 9.054758193634484 5.900502041541728 TEEALQLYNQIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEEALQLYNQIIK 13 0 O76094;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 0 6418500.0 1340300.0 2694500.0 2383700.0 False True 1757146.2794836634 2292491.1030787393 2137057.590064979 1.0 1.304667192393559 1.216209267843627 20.744802867614798 -10.115145599348343 4.445766956127593 0.999971933868324 1.2604382300758792 0.9203681377806725 0.03611279654110198 25175322.60045524 0.34307424439506656 7815.943454447416 0.012362370790084657 7.671042707901464e-11 10.115145599348343 0.26046629620755524 TEEALQLYNQIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEEALQLYNQIIK 13 0 O76094;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 0 7441400.0 2852500.0 1517100.0 3071800.0 False True 2761948.948879559 2122885.941571985 2267203.4279753184 1.0 0.7686188198493592 0.8208708668909523 21.397255222780036 -10.786788957304873 7.034223456660311 1.0064941147144437 0.7947448433702119 0.9536480626424012 0.021331808877967748 0.0022168344790486675 6.71933582901865e-05 0.021075647706025543 0.0068848117107373884 1.6338457121511245e-11 10.786788957304873 -0.21174927134423183 TEEALQLYNQIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEEALQLYNQIIK 13 0 O76094;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 0 7038300.0 1340300.0 2058600.0 3639400.0 False True 1835845.13024559 1967644.2451201484 2779848.675795786 1.0 1.0717920660643783 1.5142065253749983 20.80801292913769 -6.935271813001298 0.7021690057139551 0.9944038275939778 1.6185632614348529 0.9974767504997879 0.011421471221733995 0.08999119753415327 0.0649367907354132 0.010753798675530704 0.038936116143737945 1.1607219224492579e-07 6.935271813001298 0.624159433840875 TEEALQLYNQIIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEEALQLYNQIIK 13 0 O76094;D6RDY6 O76094 SRP72 Signal recognition particle subunit SRP72 0 5415200.0 2852500.0 1476900.0 1085800.0 False True 2371980.137176292 1468943.6465583039 1312835.7598280315 1.0 0.619290028417775 0.5534767088694461 21.177660498214312 -13.999999999999998 0.24692313909132604 3.607151211243883 0.5262287617018747 0.9995370011709492 0.004235122154393627 13.87812334106791 0.15724722774755534 17.91387663824108 0.03090095720284583 1.0000000000000041e-14 13.999999999999998 -3.0809224495420082 TEEMK(ub)WR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEEMKWR 7 1 Q9H7Z7;X6RJ95;A6NHH0 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 3111930.0 664830.0 677100.0 1770000.0 True False 643725.3355595433 947469.5610298527 1306383.9011381986 1.0 1.4718537685118247 2.029411969629337 19.296085725584902 -6.968918267542222 0.2828299603794474 0.8812780655592506 2.6370437474112536 0.9999726733679923 0.002199410467151026 0.076655255782392 0.010280670097471956 0.010133747865463153 0.0509965754233376 1.0741915518073794e-07 6.968918267542222 1.755765681852003 TEESPASDEAGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEESPASDEAGEK 13 0 A6NEL0;P05114;A6NL93 A6NEL0 HMGN1 Non-histone chromosomal protein HMG-14 0 10372550.0 557450.0 5289100.0 4526000.0 False True 730822.348353479 4499986.896750326 4057692.9364576484 1.0 6.157429239662227 5.552228863279167 19.479161226308285 -10.178537214849255 4.903074294602163 0.9995445078721316 5.854829051482639 0.9884792876807091 0.24707201908773854 0.0012302793968689738 0.00020612103173919471 0.23924239552330961 0.07974215126416855 6.629225391675994e-11 10.178537214849255 4.855284543610508 TEESPASDEAGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEESPASDEAGEK 13 0 A6NEL0;P05114;A6NL93 A6NEL0 HMGN1 Non-histone chromosomal protein HMG-14 0 7833800.0 2812900.0 1467600.0 3553300.0 False True 2723606.0292036114 2053620.3334328963 2622584.1332849464 1.0 0.7540078526090572 0.962908770638827 21.377086601301027 -10.111927234295546 6.427659045321408 1.0000002771120782 0.8584583117666478 0.37969347323871727 0.0852834426619866 3.38650279826068e-07 4.690135860833525e-08 0.08257549947451177 0.027525112761425545 7.728100579761934e-11 10.111927234295546 -0.1415419653454304 TEESPASDEAGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEESPASDEAGEK 13 0 A6NEL0;P05114;A6NL93 A6NEL0 HMGN1 Non-histone chromosomal protein HMG-14 0 8639450.0 557450.0 4342800.0 3739200.0 False True 763554.3295198119 4150920.7362808567 2856077.9712413047 1.0 5.436313535005832 3.740503931183849 19.542371287831177 -9.557537241068255 7.382535061057805 0.9999747802702463 4.588408733096124 0.8565319481067242 0.6923113718702908 0.0 0.0 0.6703276033396515 0.22344253444655043 2.7698915087646257e-10 9.557537241068255 3.588433952825877 TEESPASDEAGEK(ub)EAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEESPASDEAGEKEAK 16 1 A6NEL0;P05114;A6NL93 A6NEL0 HMGN1 Non-histone chromosomal protein HMG-14 1 6876500.0 3618000.0 3258500.0 0.0 True False 4743233.036761843 2772344.501533515 0.0 1.0 0.5844841440525482 0.0 22.1774393196142 -7.690824229658269 0.6498052264040438 0.9998807439854865 3.8177524781638384e-16 0.9874394090974685 0.045971235289231964 0.12032694085113343 0.15069303170492507 0.04275008569989872 0.07781216092164833 2.0378666888008142e-08 7.690824229658269 -0.9998807439854862 down TEESPASDEAGEK(ub)EAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEESPASDEAGEKEAK 16 1 A6NEL0;P05114;A6NL93 A6NEL0 HMGN1 Non-histone chromosomal protein HMG-14 1 8389900.0 3618000.0 2969300.0 1802600.0 True False 4955672.372773669 2838106.5078379773 1376863.0057123406 1.0 0.5726985753599165 0.27783576115257114 22.240649381137093 -8.175381184308756 0.23548982199704047 1.2154734563648895 3.4010629880455944e-10 0.9996144735087388 0.005821140735593731 0.08769799543569862 0.04918540081375737 0.09105761586606433 0.10518083925454236 6.677575632538328e-09 8.175381184308756 -1.215473456024783 down TEFLSFMNTELAAFTK ddPTM_RPMI8226_Bortezomib_8h_R1 2 TEFLSFMNTELAAFTK 16 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 909507000.0 261941000.0 443542000.0 204024000.0 False True 397383647.45220095 364388464.690537 163698566.973104 1.0 0.9169689468270513 0.4119408738196616 28.565957265242055 -6.9355467346901625 0.6997645307608025 1.0063337129726107 0.29191626336610504 0.9975205067137937 0.0129397713118031 0.08985821086627811 0.06430869435201302 0.01220549488687962 0.04438585155088121 1.1599873824922025e-07 6.9355467346901625 -0.7144174496065057 down TEFLSFMNTELAAFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEFLSFMNTELAAFTK 16 0 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 0 556510000.0 240990000.0 187500000.0 128020000.0 False True 311966305.6230887 177065460.17425346 104721673.59612702 1.0 0.5675787961158226 0.3356826417101903 28.216814976213612 -9.709390744338451 0.1555081267721217 1.629366906413114 8.119108584452988e-20 0.9997391782600559 0.00444598917338091 1.1804904452835576 0.06569128496567968 0.5040718125714904 0.18538387856873506 1.9525818841794013e-10 9.709390744338451 -1.629366906413114 TEGAEATPGAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEGAEATPGAQK 12 0 Q16666;Q16666-2;Q16666-3;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 0 5456400.0 469400.0 2952600.0 2034400.0 False True 615387.945676066 2512083.5891446588 1823899.803342781 1.0 4.0821137410887705 2.9638211410511826 19.231136658628767 -9.575135915917516 12.332347874169171 1.0000000054700948 3.522967441069977 0.8715739526004087 0.45654104220373376 0.0 2.6895127174571035e-18 0.4420439633288097 0.14734798777626987 2.6598924949828394e-10 9.575135915917516 2.522967435599882 TEGAEATPGAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEGAEATPGAQK 12 0 Q16666;Q16666-2;Q16666-3;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 0 3647400.0 469400.0 1346900.0 1831100.0 False True 642949.8650580315 1287389.504397322 1398631.892688263 1.0 2.002317092454984 2.175335852293903 19.29434672015166 -10.76258331116676 0.3430417039005518 8.057865131332265e-13 2.208508235798912 0.9992522097869727 0.01416824672120505 2.4213323013114016 0.16833389658715436 2.0487069423650976 0.052661958994694245 1.727494561623898e-11 10.76258331116676 2.2085082357981065 TEGAEATPGAQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEGAEATPGAQKR 13 1 Q16666;Q16666-2;Q16666-3;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 1906850.0 639670.0 680460.0 586720.0 True False 838613.5645730922 578938.0204123053 526011.8426156486 1.0 0.6903513666715153 0.6272398454268054 19.677646640399868 -13.999999999999995 0.22358366278765923 2.8984516350060305 0.5946191272480179 0.999501734250102 0.0036361345612503752 13.099587368295014 0.1497660285994461 11.001151572797067 0.034120089333346766 1.0000000000000123e-14 13.999999999999995 -2.3038325077580124 TEGAEATPGAQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEGAEATPGAQKR 13 1 Q16666;Q16666-2;Q16666-3;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 26243310.0 720750.0 979960.0 24542600.0 True False 697870.1857686032 1371263.1384238878 18114156.79778213 1.0 1.964925807675305 25.956341404428965 19.412599173098897 -6.91537241852288 0.8583555014735355 0.37734581456866023 29.441268887448686 0.9927957700953718 0.9798133192151464 0.10097136138079774 0.12029267879085542 0.8241389644933832 2.36926703864145 1.2151435373669285e-07 6.91537241852288 29.063923072880026 up TEGAEATPGAQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEGAEATPGAQKR 13 1 Q16666;Q16666-2;Q16666-3;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 171489480.0 611440.0 480040.0 170398000.0 True False 927599.1822516293 394373.11143036146 136718760.61190337 1.0 0.4251546562094533 147.3899106724479 19.82314202257722 -6.897285922074139 0.9799017315067057 1.909517711879308e-16 161.90249849502953 0.9885715582580049 7.391843435278772 0.1047692376733037 0.1752450216504505 5.894193294439804 15.11107514501619 1.2668175693588335e-07 6.897285922074139 161.90249849502953 up TEGAEATPGAQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEGAEATPGAQKR 13 1 Q16666;Q16666-2;Q16666-3;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 1709870.0 639670.0 513840.0 556360.0 True False 876173.2854317668 491136.8497583484 424959.2265938737 1.0 0.5605476198881396 0.48501732894590516 19.74085670192276 -13.999999999999998 0.24774407654368616 4.021779982542846 0.45398936479163865 0.9995385000536006 0.004877951429696289 13.909658440375917 0.1575058594996236 20.889339724805744 0.03529938579573018 1.0000000000000041e-14 13.999999999999998 -3.567790617751207 TEGAEATPGAQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEGAEATPGAQKR 13 1 Q16666;Q16666-2;Q16666-3;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 36060420.0 720750.0 5371470.0 29968200.0 True False 599335.559638847 5342532.824956678 36234412.062698826 1.0 8.91409284671183 60.45763759542865 19.193004448533173 -6.934124578698563 0.7121195966874974 0.32325287805122194 72.24389728545891 0.9972886492680476 1.3726843742960662 0.09055196041719513 0.06759756254622352 1.2828230062638646 4.562662471385257 1.1637921441937505e-07 6.934124578698563 71.92064440740769 TEGAEATPGAQK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEGAEATPGAQKR 13 1 Q16666;Q16666-2;Q16666-3;X6RHM1;H3BM18 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 655442810.0 611440.0 498370.0 654333000.0 True False 791521.133284292 470635.271397561 535251108.0235473 1.0 0.594595964159206 676.2309754164205 19.59426834466967 -7.715399839760023 4.839975164407014 2.6453746860723764e-09 199.99999999999997 0.25411940957203016 274.9863684987518 0.6269137038839561 35.65277416570674 248.69828732580223 125.22867306983245 1.925751124987563e-08 7.715399839760023 199.9999999973546 TEGDEEAEEEQEENLEASGDYK(ub)YSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEGDEEAEEEQEENLEASGDYKYSGR 26 1 P12956;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 29414600.0 9023800.0 9590800.0 10800000.0 True False 11830289.186603503 8159890.024645591 9682519.600915266 1.0 0.6897456094214304 0.8184516412227396 23.495982004413285 -10.07898778611304 5.006708507058626 1.0000060189573836 0.7540986255878018 0.8295556263311252 0.052544017459187776 3.530300580684073e-06 6.494624237443561e-07 0.05087677147587599 0.0169585087129618 8.337046309938333e-11 10.07898778611304 -0.24590739336958178 TEGDEEAEEEQEENLEASGDYK(ub)YSGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEGDEEAEEEQEENLEASGDYKYSGR 26 1 P12956;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 52523000.0 21193000.0 12630000.0 18700000.0 True False 20520239.815461706 17673224.864579905 13801909.012025027 1.0 0.861258202804403 0.6725997910426703 24.290544255709897 -6.9668370068863075 0.32498799192443023 1.0243701267378507 0.5033578209718012 0.9999461531050534 0.000984582808467887 0.07734303139269456 0.012691047133689537 0.0028041615227133877 0.016523401438717382 1.0793517328804422e-07 6.9668370068863075 -0.5210123057660495 TEGDEEAEEEQEENLEASGDYK(ub)YSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEGDEEAEEEQEENLEASGDYKYSGR 26 1 P12956;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 36558600.0 9023800.0 7410800.0 20124000.0 True False 12360142.719025701 7083366.351761573 15371125.66678969 1.0 0.5730812752556894 1.2436042217481234 23.559192065936177 -6.734726461377885 1.7063673369761598 0.7444403288190431 1.2435349911179903 0.5808931815910567 0.17940895451794497 0.3274375887357113 1.869895245289115 0.08325613148064084 0.205468985611262 1.8419317694649022e-07 6.734726461377885 0.49909466229894717 TEGDEEAEEEQEENLEASGDYK(ub)YSGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEGDEEAEEEQEENLEASGDYKYSGR 26 1 P12956;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 54325000.0 21193000.0 18285000.0 14847000.0 True False 17622918.509089284 18186495.075711668 17951439.055228204 1.0 1.0319797521807588 1.0186416651685406 24.070949531144173 -10.160193936165236 4.632485405053459 0.9999967422708702 1.0253107086749471 0.8276251459337413 0.005445251221813044 1.8323082257843194e-07 3.322346963320085e-08 0.00527302046708734 0.0017574472746895383 6.915220996387432e-11 10.160193936165236 0.025313966404076904 TEGEHSK(ub)EVIKPYDWTYTTDYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEGEHSKEVIKPYDWTYTTDYK 22 2 O75663;O75663-2 O75663 TIPRL TIP41-like protein 1 14111000.0 5896000.0 5078100.0 3136900.0 True False 7729713.096945213 4320467.274278766 2812323.6792695466 1.0 0.558942773178246 0.3638328672743337 22.881983436088028 -13.999999999999849 0.11059738854180454 3.1259665565126813 0.00896968019323564 0.9997400292822796 0.004290572499367668 12.009166419540168 0.10101343907000854 5.694769716685565 0.3151468835705302 1.0000000000003477e-14 13.999999999999849 -3.1169968763194458 TEGEHSK(ub)EVIKPYDWTYTTDYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEGEHSKEVIKPYDWTYTTDYK 22 2 O75663;O75663-2 O75663 TIPRL TIP41-like protein 1 19049300.0 7784500.0 8250800.0 3014000.0 True False 6473156.661822559 8206351.302744432 3644213.4648385397 1.0 1.2677510728488812 0.5629731605804343 22.626037989387957 -6.803760953252078 1.4405844214720445 1.1470315652961534 0.5523240918779937 0.8429174532777554 0.11512683849338057 0.21542903299081187 0.8822159285810123 0.06286028118615286 0.145862967240409 1.5712274099598772e-07 6.803760953252078 -0.5947074734181597 TEGEHSK(ub)EVIKPYDWTYTTDYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEGEHSKEVIKPYDWTYTTDYK 22 2 O75663;O75663-2 O75663 TIPRL TIP41-like protein 1 71129000.0 17609000.0 10048000.0 43472000.0 True False 22795197.625283044 9488819.967098124 35560542.06038765 1.0 0.4162639922267532 1.5600014812306808 24.442226581059746 -6.767947363923383 1.5821689074049359 0.6643135324582471 1.5659660428911066 0.7227198924079392 0.24589022041372913 0.2697502189293399 1.3322986330751845 0.12252057048236666 0.29221930072613006 1.7062891770910015e-07 6.767947363923383 0.9016525104328595 TEGNEQMK(ub)VENFEAAVHFYGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEGNEQMKVENFEAAVHFYGK 21 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 24011200.0 7053300.0 5818900.0 11139000.0 True False 6829396.852281226 8142417.11516263 8221361.737162929 1.0 1.1922600620935968 1.2038195927092368 22.70332673983862 -12.646461055285748 0.41901070429167625 2.2623409028218763e-05 1.2042442845599206 0.9998259588908445 0.0012331661823304074 9.489594663001242 0.21383413243290844 8.360162780226391 0.0028119733652711984 2.2570383829958556e-13 12.646461055285748 1.2042216611508925 TEGNEQMK(ub)VENFEAAVHFYGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEGNEQMKVENFEAAVHFYGK 21 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 45057400.0 11523000.0 24577000.0 8957400.0 True False 17481233.444140907 20191042.32902254 7186965.963832105 1.0 1.155012453414142 0.41112464900129353 24.059303646588106 -6.852324956948439 1.2237754376986039 1.0829174577233185 0.3800193625435506 0.943623397348348 0.07608597715604234 0.15492109689766914 0.4452980754361283 0.04861878217432795 0.11268979656927491 1.4049958551887708e-07 6.852324956948439 -0.7028980951797679 down TEGNEQMK(ub)VENFEAAVHFYGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEGNEQMKVENFEAAVHFYGK 21 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 19635200.0 7053300.0 6076900.0 6505000.0 True False 5865131.464170217 6044162.533529794 7865165.42427828 1.0 1.030524647308124 1.3410041142856162 22.483732015272896 -6.925918001796802 0.7795532152946939 0.994496785055866 1.3985913744087157 0.9956737892614623 0.010133195246090977 0.09481286223157198 0.08846930523410818 0.009016847333851774 0.028749146924935937 1.1859926517403492e-07 6.925918001796802 0.4040945893528497 TEGNEQMK(ub)VENFEAAVHFYGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEGNEQMKVENFEAAVHFYGK 21 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 39271500.0 11523000.0 18195000.0 9553500.0 True False 14916750.652287861 17182432.25530954 7814861.027187928 1.0 1.151888414295789 0.5238983481961818 23.830429968680555 -6.842810220254477 1.2691968468572943 1.0807990558062994 0.5020572293381805 0.9291849108147043 0.07119068146381005 0.16554800285325136 0.5167861102386889 0.04395955426369896 0.10136847165770099 1.436116856363781e-07 6.842810220254477 -0.5787418264681189 TEHAEFLHCK(ub)SK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEHAEFLHCKSK 12 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 1 5174250.0 664590.0 945660.0 3564000.0 True False 1008231.6180371089 776899.5845246973 2859573.8378433087 1.0 0.7705566564528259 2.8362270996921457 19.943395672257694 -6.879331041326061 1.083484678749514 0.8590025680650845 2.9807772896597595 0.9731435077562133 0.15149740759760078 0.12822610501535744 0.2758594099273171 0.10777086864174684 0.2601887624053227 1.320288859258835e-07 6.879331041326061 2.121774721594675 up TEHAEFLHCK(ub)SK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEHAEFLHCKSK 12 1 P50570;P50570-5;P50570-2;P50570-4;P50570-3 P50570 DNM2 Dynamin-2 1 2535500.0 760220.0 983450.0 791830.0 True False 1041293.8781730215 939997.9271657477 604816.0622507494 1.0 0.9027210731469965 0.5808312858920439 19.989945858661812 -6.9492288216699665 0.5672458748066115 1.0040609237402662 0.46391520895671257 0.9991393732494064 0.005254948134706787 0.08379687252468199 0.037255249618818397 0.0055849453589903765 0.026801914523683884 1.12401259663178e-07 6.9492288216699665 -0.5401457147835537 TEHINIHQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEHINIHQLR 10 0 E7EVW7;P14317;P14317-2 E7EVW7 HCLS1 Hematopoietic lineage cell-specific protein 0 13941900.0 7927900.0 0.0 6014000.0 False True 12027203.907125298 0.0 4825330.263970157 1.0 0.0 0.4012013350095011 23.519797946942408 -10.706537281811691 6.697034810588174 1.0086583221780123 0.200600667504758 0.8411054850954626 0.16378975914944843 0.02102799604475252 0.0009214414977887825 0.15749449517107023 0.052862917455428156 1.9654532499004915e-11 10.706537281811691 -0.8080576546732543 TEHINIHQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEHINIHQLR 10 0 E7EVW7;P14317;P14317-2 E7EVW7 HCLS1 Hematopoietic lineage cell-specific protein 0 8395800.0 0.0 5743900.0 2651900.0 False True 0.0 5712956.470625116 3206400.028999779 0.0 TEHINIHQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEHINIHQLR 10 0 E7EVW7;P14317;P14317-2 E7EVW7 HCLS1 Hematopoietic lineage cell-specific protein 0 23803300.0 7927900.0 7293400.0 8582000.0 False True 10262822.832272239 6887515.878586135 7020164.0587561475 1.0 0.6711132006418166 0.6840383170876437 23.290924269034857 -9.97935760069717 6.048205748292043 1.0000002164574076 0.6775757588710045 0.9987962058638168 0.005276656693195854 1.540277268682363e-08 2.5930198262345995e-09 0.005109104299911554 0.001703033624679513 1.0486785847789908e-10 9.97935760069717 -0.32242445758640303 TEHLTEEEKK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEHLTEEEKKR 11 2 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 10575700.0 2587500.0 3488200.0 4500000.0 True False 2505361.2288258914 4881056.4507226925 3321315.0028937235 1.0 1.9482445862747477 1.325683085009749 21.25658719887804 -10.488433418101012 5.057514424263479 0.9983523710733191 1.6369638356422678 0.5825920098469011 0.25415966860011957 0.004732225937910338 0.0004786640008152957 0.24663396102225463 0.0820296803138119 3.24763027929685e-11 10.488433418101012 0.6386114645689487 TEHLTEEEKK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEHLTEEEKKR 11 2 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 7744800.0 2587500.0 2688900.0 2468400.0 True False 2151620.8956857678 2674414.361995139 2984531.027407911 1.0 1.242976570527656 1.3871082184562429 21.036992474312317 -11.374880577467778 0.07434971906658365 5.5222010946681635e-09 1.9381941685845168 0.9999543410950354 0.001079399077080197 4.228425446987681 0.05019442582332712 1.0793386831821248 0.3750534092045467 4.218124777064538e-12 11.374880577467778 1.9381941630623156 TEIDKPSQMQVTDVQDNSISVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEIDKPSQMQVTDVQDNSISVK 22 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 9794200.0 3246400.0 2276600.0 4271200.0 False True 3143344.8089895155 3185658.252312164 3152444.5867465963 1.0 1.0134612795903388 1.002894934634933 21.583869106473287 -6.58526193476803 2.245706179410025 1.009136930084981 1.0029226603915282 0.0 0.005840049676995024 0.683539089710701 6.490962253748501 0.0021762496402097983 0.006521820820778227 2.598591809313611e-07 6.58526193476803 -0.006214269693452845 TEIDLK(ub)AHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEIDLKAHR 9 1 H3BQQ2;H3BPG6;Q86UK7-2;Q86UK7-3;Q86UK7 H3BQQ2 ZNF598 Zinc finger protein 598 1 7267700.0 1434700.0 2054000.0 3779000.0 True False 1857247.4321650069 1939693.094388891 3091260.7758144345 1.0 1.0443913184619544 1.664431309624119 20.824734600740594 -6.921319968940958 0.8148766424140558 0.9869593698506358 1.7675186494515136 0.9945398302424319 0.02241134378887362 0.09740124215236587 0.10163507453922281 0.019445888198056985 0.05900548136254349 1.198615890653801e-07 6.921319968940958 0.7805592796008778 TEIIILATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEIIILATR 9 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 0 64213000.0 17866000.0 24940000.0 21407000.0 False True 23422499.014590133 21219049.215358578 19192008.990443822 1.0 0.9059259305397344 0.8193834901429138 24.48139167359544 -6.972124428607046 0.201069106625365 1.0508068645684019 0.672110347884729 0.9999945501946453 0.00017208929980035219 0.07561921319570328 0.006500803992934859 0.0027851856152916747 0.009162845938724044 1.0662905772616798e-07 6.972124428607046 -0.3786965166836729 TEIIILATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEIIILATR 9 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 0 79401000.0 21883000.0 17448000.0 40070000.0 False True 21188336.143148594 24415077.390118007 29574464.92576704 1.0 1.1522885622150565 1.3957898688203587 24.336766965830282 -6.964173855769756 0.37195832408096796 0.9816854001658001 1.5748950929812144 0.9998950886158317 0.0016695845053772097 0.0782424338253306 0.015855296720489093 0.0032002955759285506 0.020658905392924216 1.085990795246655e-07 6.964173855769756 0.5932096928154144 TEIIILATR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEIIILATR 9 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 0 324324000.0 92747000.0 134270000.0 97307000.0 False True 140703979.7139404 110308469.44370182 78074228.79882672 1.0 0.7839754758036377 0.5548828750796978 27.068087893873543 -6.970381031332464 0.24892080966664454 1.0736752992713647 0.25848246006152525 0.9999852019167423 0.0006991155831657174 0.07617926235746018 0.00858678591641827 0.0051472080740657955 0.02199526451629452 1.070579612487013e-07 6.970381031332464 -0.8151928392098395 TEIIILATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEIIILATR 9 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 0 69806000.0 17866000.0 23442000.0 28498000.0 False True 24471543.01049596 22406254.92767244 21767359.33473332 1.0 0.9156045010346217 0.8894968055507245 24.54460173511833 -13.999999999999998 0.164303093742079 1.4196383202569463 0.8650123609332947 0.9995257027218991 0.001027015083839635 12.041105161562003 0.12822624937243696 1.6100059768327566 0.02244207304510865 1.0000000000000041e-14 13.999999999999998 -0.5546259593236516 TEIIILATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEIIILATR 9 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 0 50781000.0 21883000.0 15007000.0 13891000.0 False True 18196684.08127214 14926154.312343732 16795543.875272766 1.0 0.8202678161405018 0.9230002455534514 24.11717224126456 -10.140131563656311 4.709776278492944 1.0000114462084533 0.8716340308547031 0.6755064439455338 0.041940338687400006 5.0412178489493084e-06 9.204060845914499e-07 0.04061217867216236 0.013536186105265125 7.242165352083523e-11 10.140131563656311 -0.12837741535375014 TEIIILATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEIIILATR 9 0 P23396;P23396-2;E9PL09;E9PPU1;H0YEU2;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 0 273086000.0 92747000.0 96647000.0 83692000.0 False True 120062819.81669192 91268509.49045919 68460914.75243759 1.0 0.7601729630355595 0.5702091193340414 26.839214215965992 -6.973752505358992 0.14240164290342405 1.2458439637448309 0.07957350115979267 0.999998840606246 0.0001892636297257853 0.07510278629685939 0.004321816871327895 0.010472646411368296 0.02447488962733146 1.0623007660088665e-07 6.973752505358992 -1.1662704625850382 TEILPPFFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEILPPFFK 9 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 8514600.0 1853300.0 2931800.0 3729500.0 False True 2429694.247382732 2494386.868066893 3343607.1158901374 1.0 1.0266258278192195 1.376143158544279 21.212343345896794 -6.922137689570949 0.8086961609887592 0.9928665000265199 1.4353773700553945 0.9947549063876309 0.012412208559138518 0.09692982588938533 0.0992097525349543 0.010817357108346923 0.0330969410425595 1.1963611744905227e-07 6.922137689570949 0.44251087002887457 TEILPPFFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEILPPFFK 9 0 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 8899400.0 1853300.0 3707800.0 3338300.0 False True 2538515.093549321 3543977.1359450496 2549862.294446638 1.0 1.3960827512709029 1.0044700151384371 21.275553407419686 -9.773111181120685 11.57139216354415 0.9999996865100494 1.2002763832213603 0.25855967934486945 0.15987523005005747 0.0 0.0 0.15479852586369178 0.05159950862123058 1.686121316344998e-10 9.773111181120685 0.20027669671131088 TEISVESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEISVESK 8 0 D6RG15;Q6IBS0;H0Y858 D6RG15;H0Y858 TWF2 Twinfilin-2 0 6848200.0 2062200.0 2336100.0 2449900.0 False True 2703564.1703732065 1987562.9860464775 2196407.8491002186 1.0 0.7351639764378551 0.8124119535128405 21.36643116919905 -10.07901100573341 6.943756793641436 1.0000000910735196 0.7737879649753477 0.9195749691507522 0.03153635458265476 4.4466802682523724e-08 5.897468051058451e-09 0.03053495630978187 0.010178314674892776 8.336600580407997e-11 10.07901100573341 -0.22621212609817187 TEISVESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEISVESK 8 0 D6RG15;Q6IBS0;H0Y858 D6RG15;H0Y858 TWF2 Twinfilin-2 0 5310060.0 1551300.0 981060.0 2777700.0 False True 1502054.8306386892 1372802.3741603144 2050137.0407861995 1.0 0.9139495750475265 1.364888284347423 20.518506046921175 -6.8572857080142215 1.1993250328045393 0.9536070036184437 1.3856246601458255 0.9502591688635513 0.04359608277122216 0.14962595740932716 0.41050406401008993 0.028380589846596797 0.06606143107249125 1.389038527937731e-07 6.8572857080142215 0.4320176565273818 TEISVESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEISVESK 8 0 D6RG15;Q6IBS0;H0Y858 D6RG15;H0Y858 TWF2 Twinfilin-2 0 9164200.0 1251200.0 6338300.0 1574700.0 False True 1898161.8749725865 5207180.843636066 1263459.8547844712 1.0 2.7432754351950455 0.6656228172334977 20.856171599755875 -6.684148711538528 1.8870649555065617 2.0988451161246715 0.6732376593886502 0.3432609241097717 0.7381787872936677 0.42936429878877375 2.959546387325791 0.3134740292676833 0.8224232456735344 2.0694326103290675e-07 6.684148711538528 -1.4256074567360213 TEISVESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEISVESK 8 0 D6RG15;Q6IBS0;H0Y858 D6RG15;H0Y858 TWF2 Twinfilin-2 0 7246500.0 2062200.0 2662700.0 2521600.0 False True 2824651.0688595492 2545053.1096285875 1926050.0139821568 1.0 0.9010150448976166 0.6818718372743285 21.42964123072194 -6.958010463877491 0.4626273971884967 1.0062227697875008 0.5677910994138883 0.9996891208938105 0.002343737834465841 0.08041973499555012 0.023816989354072404 0.0029897278765002653 0.018098457193516194 1.1015127694079114e-07 6.958010463877491 -0.4384316703736125 TEISVESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEISVESK 8 0 D6RG15;Q6IBS0;H0Y858 D6RG15;H0Y858 TWF2 Twinfilin-2 0 3892360.0 1551300.0 1598300.0 742760.0 False True 1289974.6842424478 1589689.6406622913 898067.681865785 1.0 1.2323417351371158 0.6961901600365014 20.29891132235545 -6.788906220165253 1.5005176610409798 1.1300379618903496 0.6906429872894393 0.7978372209944481 0.0987063036707148 0.23697361599970365 1.0540547383834853 0.05177929583298449 0.12133481791571275 1.6258998082281681e-07 6.788906220165253 -0.43939497460091026 TEIVFTGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEIVFTGEK 9 0 A0A024R4E5;Q00341;Q00341-2;H0Y394;H7C0A4 A0A024R4E5 HDLBP Vigilin 0 5741700.0 1711600.0 1671200.0 2358900.0 False True 2243924.175157976 1421863.4742865765 2114823.6561665786 1.0 0.6336504103069681 0.9424666303698482 21.097592495729085 -10.05863641063995 6.991537618394917 1.0000000555439823 0.7880585203384081 0.3857552837447845 0.1260736939081833 1.0922656839501956e-07 1.4569538279332298e-08 0.12207036196703273 0.040690109741770404 8.73702522053897e-11 10.05863641063995 -0.21194153520557424 TEIVFTGEK(ub)EQLAQAVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEIVFTGEKEQLAQAVAR 18 1 A0A024R4E5;Q00341;Q00341-2;H0Y394;H7C0A4 A0A024R4E5 HDLBP Vigilin 1 10745300.0 3280300.0 2790100.0 4674900.0 True False 3176168.6720454358 3904201.480179288 3450403.4460061956 1.0 1.2292173002465272 1.0863413761285399 21.598856098890046 -10.57723499372507 4.808425161354759 0.998537096009933 1.1577793381873225 0.6191928765603244 0.058328851769639325 0.0009229955638520536 8.115123578745739e-05 0.05698551198393602 0.018825555958930734 2.6470674412395503e-11 10.57723499372507 0.15924224217738947 TEK(ub)EVIGGLCRRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEKEVIGGLCRRR 13 3 I3L301 I3L301 TFAP4 1 54506400.0 42304000.0 8824900.0 3377500.0 True False 55460953.672518715 7508259.319190769 3028028.699267714 1.0 0.1353791960290644 0.05459748703831112 25.72496908850065 -13.892416774711808 0.3362435353375109 9.99907012337083 0.04122318485571002 0.999724066137835 0.007107943869650255 17.985795145273425 0.18548372284094863 114.45645591114014 0.025312701001882508 1.2811005725551807e-14 13.892416774711808 -9.95784693851512 TEK(ub)EVIGGLCRRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEKEVIGGLCRRR 13 3 I3L301 I3L301 TFAP4 1 172143800.0 42304000.0 5069800.0 124770000.0 True False 57944932.022613876 4845799.472413354 95301895.71881087 1.0 0.08362766687727251 1.644697687825708 25.78817915002354 -6.747625962774398 1.6587835072487978 0.45963323025343483 1.6472195593037273 0.6386512294369522 0.38502709179428873 0.3041943486592302 1.646089699637279 0.18342544332850852 0.4463964233539445 1.788026854572521e-07 6.747625962774398 1.1875863290502924 TEK(ub)HQLEVDEWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEKHQLEVDEWR 12 1 H3BR29;H3BSM7;Q96GQ5;Q96GQ5-2 H3BR29 C16orf58 RUS1 family protein C16orf58 1 20402400.0 1530600.0 7669800.0 11202000.0 True False 2322032.1018486577 6301064.26557908 8987919.789988982 1.0 2.7135991188763344 3.870712977151934 21.14695648677215 -8.188469807845774 0.2176746648548099 1.0047195825679832e-16 5.132662503515062 0.9996959360021734 0.020563625526214865 0.08954756191445445 0.0465214922289088 0.41329455678035365 0.46417420806856563 6.479331380175821e-09 8.188469807845774 5.132662503515062 TEK(ub)HQLEVDEWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEKHQLEVDEWR 12 1 H3BR29;H3BSM7;Q96GQ5;Q96GQ5-2 H3BR29 C16orf58 RUS1 family protein C16orf58 1 6237560.0 739960.0 1667500.0 3830100.0 True False 615309.5257861414 1658516.846527166 4630956.20161848 1.0 2.6954187722157976 7.526222181757717 19.230952801931117 -6.95260310701965 0.52949596246453 0.9235342098708762 9.517216915715615 0.999390046818697 0.06828568638704159 0.08245701680601887 0.03176453299802356 0.0762396029825903 0.3994557278999475 1.1153133303821914e-07 6.95260310701965 8.593682705844738 TEK(ub)HQLEVDEWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEKHQLEVDEWR 12 1 H3BR29;H3BSM7;Q96GQ5;Q96GQ5-2 H3BR29 C16orf58 RUS1 family protein C16orf58 1 20006500.0 1530600.0 8504300.0 9971600.0 True False 1981391.872636623 8031028.229119485 8156871.117256197 1.0 4.053225583504921 4.116737950682069 20.9180828088646 -10.360533270843046 0.7691351280820021 6.817167737125768e-18 4.103924497383769 0.9999468325764774 0.01060566988901109 1.7194312714823776 0.4013444239967937 3.6373919204363423 0.009350714510414282 4.3598016273971733e-11 10.360533270843046 4.103924497383769 TEK(ub)QMTCTDINTLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEKQMTCTDINTLTR 15 1 Q5BJF6-8;Q5BJF6-5;Q5BJF6-6;Q5BJF6-10;Q5BJF6-7;Q5BJF6-2;Q5BJF6-3;Q5BJF6-4;Q5BJF6;Q5T4C3;Q5BJF6-9;Q5T4C6 Q5BJF6-8 ODF2 Outer dense fiber protein 2 1 7167000.0 1876600.0 3295200.0 1995200.0 True False 2460240.7730202484 2803569.004588997 1788755.8433098313 1.0 1.1395506632252383 0.7270653599947916 21.230368082061183 -6.8154310338951465 1.391468677547327 1.0755833133541404 0.7189094256549059 0.8735531734769186 0.060915335213415724 0.19949305095207914 0.7601563664253185 0.034411397776831526 0.07942760338612677 1.529568623128216e-07 6.8154310338951465 -0.35667388769923447 TELAEPIAIRPTSETVMYPAYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TELAEPIAIRPTSETVMYPAYAK 23 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 22541600.0 2150100.0 8961500.0 11430000.0 False True 2818801.921598021 7624479.131653414 10247333.244301993 1.0 2.7048651674435438 3.635350595508544 21.426650672004243 -8.819314351547499 0.2393954099969415 1.809098921727415e-21 4.365532250846883 0.9993066715623085 0.028733848441792224 0.3423370457826706 0.07488225962443716 0.6822019032490738 0.39955348722092393 1.5159526915697304e-09 8.819314351547499 4.365532250846883 TELAEPIAIRPTSETVMYPAYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TELAEPIAIRPTSETVMYPAYAK 23 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 21787300.0 6282900.0 3763400.0 11741000.0 False True 6083452.778585586 5266145.245871739 8665679.877550049 1.0 0.8656507147403433 1.4244673531541467 22.536458954285447 -6.8432255312453165 1.267342032640902 0.9285329465274998 1.4440517005257472 0.9298612864486977 0.06307464161428851 0.1650611411847004 0.5135880522591725 0.039003593920675296 0.08994919344229588 1.4347441702068897e-07 6.8432255312453165 0.5155187539982473 TELAEPIAIRPTSETVMYPAYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TELAEPIAIRPTSETVMYPAYAK 23 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 24469100.0 2150100.0 10451000.0 11868000.0 False True 2945050.0742677357 9989240.263164604 9065022.829132397 1.0 3.3918745051044175 3.0780538872115257 21.489860733527134 -10.212622962462698 5.995323043182451 0.9999574738845194 3.2349641961579803 0.9854283701222873 0.12811673076713573 7.283136330577039e-05 9.56562143351292e-06 0.12405081004807368 0.04134949705263079 6.128822412932231e-11 10.212622962462698 2.235006722273461 TELDAHFENLLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TELDAHFENLLAR 13 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9 Q9NR46 SH3GLB2 Endophilin-B2 0 12663500.0 3893300.0 5075600.0 3694600.0 False True 5104154.002770829 4318340.264533838 3312318.233105704 1.0 0.8460442733878316 0.6489455904558497 22.283240428145202 -6.967756850823211 0.3070929718019485 1.0314261744995268 0.4573249019114028 0.999959208726573 0.0009176230448672289 0.07703765969582557 0.011622903575488256 0.0031603340642885926 0.01754859632595485 1.0770680647504086e-07 6.967756850823211 -0.574101272588124 TELDAHFENLLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TELDAHFENLLAR 13 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9 Q9NR46 SH3GLB2 Endophilin-B2 0 18164000.0 5596600.0 4151000.0 8416400.0 False True 5418938.996423956 5808515.947179031 6211892.353412163 1.0 1.071891739510661 1.1463300025173728 22.369578975434642 -6.97068823425839 0.2411816074039706 0.9736599424643041 1.24671797059662 0.9999872549204735 0.0002132022438188054 0.07607994238897785 0.008226944108921691 0.0017645706961360735 0.007241786672405806 1.0698225941267637e-07 6.97068823425839 0.27305802813231594 TELDAHFENLLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TELDAHFENLLAR 13 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9 Q9NR46 SH3GLB2 Endophilin-B2 0 23212500.0 4611900.0 15462000.0 3138600.0 False True 6996589.475052794 12702685.294842608 2518254.334302748 1.0 1.8155538981007253 0.3599259815488526 22.738220413316323 -6.754667713762502 1.6323863718461988 1.4768618465679049 0.3559455179068048 0.6688154256963074 0.34281450675772807 0.29200697924681573 1.5322128076122012 0.16579542444004863 0.400583119609375 1.759269146472464e-07 6.754667713762502 -1.1209163286611001 TELDAHFENLLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TELDAHFENLLAR 13 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9 Q9NR46 SH3GLB2 Endophilin-B2 0 12128100.0 3893300.0 3915900.0 4318900.0 False True 5332758.222476424 3742882.5898503754 3298864.7705375687 1.0 0.7018661701321718 0.6186038505615287 22.346450489668094 -13.999999999999998 0.17894628793150422 2.5419326998672935 0.551739761079585 0.9994994456882604 0.003663227974718519 12.191318364533128 0.1340908285509765 6.534444085405246 0.062728024689186 1.0000000000000041e-14 13.999999999999998 -1.9901929387877084 TELDAHFENLLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TELDAHFENLLAR 13 0 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9 Q9NR46 SH3GLB2 Endophilin-B2 0 11735700.0 5596600.0 3755900.0 2383200.0 False True 4653820.871418346 3735666.221212222 2881516.1013282016 1.0 0.8027094992321229 0.6191721127525911 22.14998425086892 -6.9719943302155665 0.20502868367184973 1.1024020053245682 0.3143842107601089 0.99999404252382 0.0003795145298365477 0.07566070899340183 0.00666160823574402 0.005719403560943471 0.019243883216119567 1.0666100459053617e-07 6.9719943302155665 -0.7880177945644593 TELEDTLDSTAAQQELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TELEDTLDSTAAQQELR 17 0 P35579 P35579 MYH9 Myosin-9 0 10676400.0 1398400.0 4507200.0 4770800.0 False True 1833315.9421248653 3834743.3289279905 4277163.380745059 1.0 2.0916980215005463 2.333020338975346 20.806024001606197 -10.539810031108573 0.31424054747909574 8.735580162672378e-12 2.399167442884511 0.9991035649021811 0.017363738163703235 2.107861489287111 0.15219336238421963 1.745986568002391 0.08162528543179506 2.88529331080248e-11 10.539810031108573 2.3991674428757754 TELEDTLDSTAAQQELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TELEDTLDSTAAQQELR 17 0 P35579 P35579 MYH9 Myosin-9 0 11312900.0 2195900.0 1997900.0 7119100.0 False True 2126192.3564748913 2795671.8889108654 5254394.141577939 1.0 1.3148725139553854 2.4712694152891377 21.019840692617837 -6.94683842052792 0.592537286411565 0.9867309507822069 2.857853495325657 0.9989292479886945 0.020698395418400205 0.08478065605539087 0.04141177594811377 0.021403064910956098 0.09695173912988758 1.1302163339931422e-07 6.94683842052792 1.87112254454345 up TELEDTLDSTAAQQELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TELEDTLDSTAAQQELR 17 0 P35579 P35579 MYH9 Myosin-9 0 8518300.0 1398400.0 3606400.0 3513500.0 False True 1915426.2703390548 3447057.323230012 2683683.6628039 1.0 1.7996293444486584 1.401089514308924 20.86923406312909 -10.406560020608099 5.559727460682945 0.9996986677546894 1.6003594293787788 0.7515925911296641 0.1627032043363152 0.0006080081240301835 6.489827598139658e-05 0.15761340249672168 0.052512233397426146 3.9213894798206187e-11 10.406560020608099 0.6006607616240894 TELFIAAEGIHTGQFVYCGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TELFIAAEGIHTGQFVYCGK 20 0 P62917;E9PKZ0;E9PKU4;G3V1A1 P62917 RPL8 60S ribosomal protein L8 0 64496000.0 14137000.0 26232000.0 24127000.0 False True 21446862.553138934 21550694.648448538 19358287.874760233 1.0 1.0048413652604122 0.9026163070144253 24.35426327650084 -6.895785666060105 0.9875452953803536 1.004755406039249 0.8927596210978647 0.9843498019484181 0.005890957973611008 0.11457354390050221 0.1954387575687734 0.00450712480604108 0.011497243424075805 1.2712013164121004e-07 6.895785666060105 -0.11199578494138429 TELFIAAEGIHTGQFVYCGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TELFIAAEGIHTGQFVYCGK 20 0 P62917;E9PKZ0;E9PKU4;G3V1A1 P62917 RPL8 60S ribosomal protein L8 0 40991100.0 14137000.0 18709000.0 8145100.0 False True 18300625.181931216 17667827.703467246 6662775.375783581 1.0 0.9654220840996869 0.36407364827961997 24.12538959859329 -6.918721958570206 0.8341568837952056 1.0138896359749714 0.26989725054792646 0.9938182944297498 0.022955790500779467 0.09892977888348903 0.10955618424159479 0.01964600906400783 0.05814846081586313 1.2058076683225398e-07 6.918721958570206 -0.7439923854270449 down TELGAK(ub)AFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TELGAKAFK 9 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 7947300.0 3721400.0 3022600.0 1203300.0 True False 4878791.438088862 2571639.862002522 1078794.0588686445 1.0 0.5271059225704254 0.221119117830385 22.218092380592587 -8.358693098508478 0.2625603877361514 1.2016393221836177 4.526539107043306e-21 0.99930341592899 0.008456307278515332 0.1147039711945729 0.06400129300577274 0.10883426274685894 0.10446127978606969 4.3783139677415596e-09 8.358693098508478 -1.2016393221836177 down TELGAK(ub)AFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TELGAKAFK 9 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 7931900.0 3559400.0 3022600.0 1349900.0 True False 3446408.7953170547 4229539.942650773 996320.6938680538 1.0 1.2272310668420499 0.28908952856139536 21.71666240611562 -6.842731272934988 1.2697879345575571 1.120867293070651 0.25655440495503284 0.9290246308922289 0.10645883037891385 0.16563664883992782 0.5176151473866242 0.06571234885448952 0.15150587841110982 1.4363779416105098e-07 6.842731272934988 -0.8643128881156181 down TELGAK(ub)AFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TELGAKAFK 9 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 16587200.0 10354000.0 3955800.0 2277400.0 True False 15707774.978793286 3249856.583193534 1827270.8917801194 1.0 0.20689477584069624 0.1163290723381941 23.904975500196812 -13.999999999999998 0.30627071298926545 8.501498672011145 0.09546049064863528 0.9996637699802831 0.007278621049586605 17.00855763812791 0.1759547815931134 81.14125606789028 0.03187192938613705 1.0000000000000041e-14 13.999999999999998 -8.40603818136251 TELGAK(ub)AFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TELGAKAFK 9 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 6988100.0 3721400.0 2139300.0 1127400.0 True False 5097302.1470535975 2044778.6522809325 861131.3395318382 1.0 0.40114919486632344 0.1689386492479359 22.28130244211548 -10.408943990326248 0.21253148211107423 1.7481613152474353 4.8981587771594875e-26 0.9993159923431891 0.009156671705361125 2.076109220542567 0.10617759983262355 0.9639490031019438 0.12912570245456553 3.899922795832699e-11 10.408943990326248 -1.7481613152474353 TELGAK(ub)AFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TELGAKAFK 9 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 10375610.0 3559400.0 5833600.0 982610.0 True False 2959798.8081561057 5802173.238921056 1188069.2079246854 1.0 1.9603269056438641 0.4014020157893193 21.497067681549897 -6.740016225566771 1.6864166820410635 1.5713620666843007 0.40044123810249926 0.6051457441073935 0.40348796659228975 0.3177686901041837 1.774456530042142 0.18926793542913084 0.46447776354280645 1.8196328744944315e-07 6.740016225566771 -1.1709208285818014 TELIQK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TELIQKAK 8 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 249202400.0 84846000.0 91658000.0 72698400.0 True False 111233927.64983273 77982983.68008569 65176266.94029444 1.0 0.7010719240767811 0.5859387357557939 26.729021653155474 -13.999999999997067 0.13211044258115243 2.421221078335234 0.4289422368252168 0.9996361681882124 0.0033285229175231785 11.934042721295212 0.11323387722402518 4.396187370640396 0.13974064473307882 1.000000000006753e-14 13.999999999997067 -1.992278841510017 TELIQK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TELIQKAK 8 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 347489000.0 117030000.0 156530000.0 73929000.0 True False 113314946.70898326 219033245.29316622 54564777.07754002 1.0 1.9329598755907278 0.4815320367018651 26.755762930237072 -6.733127713710272 1.711885721136304 1.559484094730341 0.48189798704016507 0.5736961194051104 0.39210617066299086 0.3303966340976983 1.8982665859584067 0.18141183807480632 0.44856569184073214 1.8487248813912914e-07 6.733127713710272 -1.077586107690176 TELIQK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TELIQKAK 8 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 272367000.0 122170000.0 71204000.0 78993000.0 True False 185340821.82336998 58497089.88060877 63379998.926138125 1.0 0.31561902717986523 0.34196459421410863 27.465605432994778 -10.526106524750357 6.244725031765573 1.0007370938698272 0.32879181069699553 0.9988458547526285 0.010755532703031019 0.00011048351429178042 8.38424629640035e-06 0.010424259018371426 0.0034713332532023563 2.97778594165374e-11 10.526106524750357 -0.6719452831728316 TELIQK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TELIQKAK 8 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 235009230.0 84846000.0 74432000.0 75731230.0 True False 116215859.07693592 71143348.12629105 57845073.2076403 1.0 0.6121655744005948 0.4977382060166707 26.792231714678366 -13.999999997904872 0.1711021560705748 2.9615672100575217 0.39797544608090213 0.9995116182180698 0.0047499375441017655 12.1024574122982 0.13100959278628546 7.8802584152834845 0.09236347100813604 1.0000000048242096e-14 13.999999997904872 -2.5635917639766195 TELIQK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TELIQKAK 8 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 380213000.0 117030000.0 195040000.0 68143000.0 True False 97315630.3080601 193989280.8075909 82391386.24236657 1.0 1.9934031171919964 0.8466408323262185 26.53616820567135 -6.677600564667284 1.9101702512307135 1.629888256667744 0.851062379975097 0.31321435710904955 0.42125126731933654 0.4439171498471097 3.129425488616651 0.17708169444961525 0.4685232112783 2.1008712376980505e-07 6.677600564667284 -0.7788258766926469 TELIQK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TELIQKAK 8 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 229215000.0 122170000.0 77661000.0 29384000.0 True False 158151473.33073035 73339097.08049433 24036413.505300682 1.0 0.46372692922768893 0.15198349404583242 27.236731755087227 -8.565556929380401 0.30236339726432554 1.1825745760495643 7.033273874488361e-13 0.9987066579811017 0.012595087774961397 0.20091208575627978 0.0864490830703098 0.1303835153244351 0.09677658218237455 2.7192120155281984e-09 8.565556929380401 -1.1825745760488608 TELLAGQKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TELLAGQKK 9 1 Q9Y548 Q9Y548 YIPF1 Protein YIPF1 0 2248030.0 916420.0 706470.0 625140.0 False True 1201435.4946239053 601067.429798492 560456.5095663127 1.0 0.500291053900192 0.4664890558620933 20.19632776120901 -13.999999999999998 0.3826462178871906 8.539525774264838 0.4636559041985082 0.9998117497078058 0.0033467232429560873 24.372862913352698 0.2019958131993216 151.53806926661346 0.009089658566151184 1.0000000000000041e-14 13.999999999999998 -8.075869870066331 TELLAGQKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TELLAGQKK 9 1 Q9Y548 Q9Y548 YIPF1 Protein YIPF1 0 3349370.0 1037000.0 1684600.0 627770.0 False True 862311.4468893302 1675524.725433079 759033.8045194731 1.0 1.9430621401087784 0.8802316231073855 19.717849505851493 -6.672580054407408 1.9279670886308728 1.6006202795088387 0.8844573717139449 0.2905314644921708 0.40035763415584297 0.45528661401482 3.2649870922474893 0.16701953726291402 0.4447806456383296 2.125298548394911e-07 6.672580054407408 -0.7161629077948938 TEMDWVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEMDWVLK 8 0 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 24667800.0 5559000.0 8584800.0 10524000.0 False True 7287902.833432569 7303981.303288297 9435077.433336325 1.0 1.002206186089909 1.2946217381019125 22.79707229374138 -6.9085525228864215 0.905519584822012 0.9905264369861118 1.331266431953141 0.9903640784491977 0.013582672418759071 0.10538364773603301 0.14401110966793582 0.011041314339791915 0.03018245293674535 1.2343760226631881e-07 6.9085525228864215 0.34073999496702934 TEMDWVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEMDWVLK 8 0 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 20627000.0 6580900.0 3776100.0 10270000.0 False True 6371992.931702541 5283916.4221013645 7579978.906604126 1.0 0.8292407852200093 1.1895774191605737 22.60331323584161 -6.777857514793591 1.5443798919252545 0.9030420610604114 1.1922341957267786 0.7596771409414134 0.07214855774773689 0.253919936538364 1.1961025555243074 0.0368020660086729 0.08698839406117025 1.6677942999466315e-07 6.777857514793591 0.2891921346663672 TEMDWVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEMDWVLK 8 0 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 34985300.0 6952300.0 24436000.0 3597000.0 False True 10547147.381211566 20075204.880660582 2886051.3733788966 1.0 1.9033776769273243 0.2736333597196185 23.330349519497528 -6.756214637155531 1.6265809918613994 1.5271713265791693 0.2687247579848524 0.6754503475639664 0.37978396639835893 0.2892855205421811 1.5075521672681318 0.1842990117269796 0.4445951753992933 1.753013912628781e-07 6.756214637155531 -1.258446568594317 TEMDWVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEMDWVLK 8 0 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 22230800.0 5559000.0 7673700.0 8998100.0 False True 7614312.526326361 7334650.560467537 6872934.101686571 1.0 0.9632715409445176 0.9026335703878077 22.86028235526427 -6.963617707277151 0.38108396102861375 1.0041148237812494 0.8596424689722563 0.9998816541356353 0.0004367105126304406 0.07843384971603057 0.016537409797954455 0.0007882844772648278 0.005121177805800242 1.0873823833306871e-07 6.963617707277151 -0.14447235480899312 TEMDWVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEMDWVLK 8 0 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 15687300.0 6580900.0 4885200.0 4221200.0 False True 5472309.93330183 4858882.457963718 5103833.4033763865 1.0 0.8879033748426621 0.9326652666942211 22.383718511275887 -10.702498631972874 8.942997188421788 1.0001960263489647 0.9102843208842925 0.8426738264893353 0.018273965826327277 7.1576976480951e-05 2.381090664318387e-06 0.01773206698957542 0.005897897109544082 1.983815905844518e-11 10.702498631972874 -0.0899117054646722 TEMDWVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEMDWVLK 8 0 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 21339200.0 6952300.0 6804000.0 7582900.0 False True 8999889.400321176 6425351.418803315 6202890.00712444 1.0 0.713936708886002 0.6892184704962129 23.101475841589977 -13.999999999999998 0.34674549854998427 4.448143168852921 0.6856548636830055 0.9997484584172002 0.002236882163969389 20.340469267624144 0.18933311665157787 51.57958757273803 0.007458112432081356 1.0000000000000041e-14 13.999999999999998 -3.7624883051699154 TEMDWVLK(ub)HSGPNSADSANDGFVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEMDWVLKHSGPNSADSANDGFVR 24 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 19151000.0 6796400.0 6869000.0 5485600.0 True False 8910146.216431227 5844171.975152284 4918002.733590822 1.0 0.6559007936788994 0.5519553343043371 23.087017676042123 -13.999999999999998 0.16772186967131625 2.725197437729562 0.45800391077802594 0.9995182108196394 0.004202743270302358 12.070168966408898 0.1296397324142923 6.773704606419938 0.08653599498998912 1.0000000000000041e-14 13.999999999999998 -2.267193526951536 TEMDWVLK(ub)HSGPNSADSANDGFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEMDWVLKHSGPNSADSANDGFVR 24 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 27347900.0 6597300.0 7298600.0 13452000.0 True False 6387872.32267944 10212969.041696182 9928517.648650311 1.0 1.5988060696573656 1.554276157555654 22.606904046557034 -10.230293721967065 5.0102045902648715 0.9999197568592958 1.5765411136068954 0.9955458413656543 0.018179260491606355 1.6298142751955997e-05 2.503866465328293e-06 0.017604427724485887 0.0058673310939708415 5.884455433596051e-11 10.230293721967065 0.5766213567475996 TEMDWVLK(ub)HSGPNSADSANDGFVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEMDWVLKHSGPNSADSANDGFVR 24 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 98403700.0 16505400.0 22031300.0 59867000.0 True False 25039898.506371878 18099642.383667454 48034261.20936171 1.0 0.7228320985031811 1.9183089419127828 24.577725378852247 -6.845677059142263 1.255882666153911 0.8524796288558784 1.96223002851825 0.9337592082131961 0.13149484593506158 0.16227749525011226 0.49473487161406277 0.08201635185402689 0.18932702987510763 1.4266680679399704e-07 6.845677059142263 1.1097503996623717 TEMDWVLK(ub)HSGPNSADSANDGFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEMDWVLKHSGPNSADSANDGFVR 24 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 24384400.0 6796400.0 7328700.0 10259300.0 True False 9309212.745804023 7004893.80122998 7836264.636915912 1.0 0.7524689780440695 0.8417752232000478 23.150227737565015 -10.909526357858805 10.579603329068688 1.0223902784141958 0.7971221006220588 0.8731107601172933 0.03645912191267479 0.016486367447574136 0.0001409863129310797 0.030225933143051914 0.011767130998761272 1.2316112354884955e-11 10.909526357858805 -0.22526817779213704 TEMDWVLK(ub)HSGPNSADSANDGFVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEMDWVLKHSGPNSADSANDGFVR 24 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 26313000.0 6597300.0 11508000.0 8207700.0 True False 5485947.25994501 11446004.119840847 9923892.121882983 1.0 2.086422558855511 1.8089660092690096 22.38730932199131 -10.062216384087618 4.441350780173495 0.9999373607914471 1.9476942841416363 0.9395972850072809 0.11327116232190833 14868152.403203772 8421235.721979171 8675.833062919866 0.038775731421961 8.665300258598238e-11 10.062216384087618 0.9477569233501891 TEMDWVLK(ub)HSGPNSADSANDGFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEMDWVLKHSGPNSADSANDGFVR 24 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 100957400.0 16505400.0 21145000.0 63307000.0 True False 21366565.6700748 19968262.162051138 51785775.584674306 1.0 0.9345564687551977 2.4236827005475896 24.348851700944696 -6.896621992617223 0.9823922874730815 0.9322196447792339 2.5696891659786183 0.9848089580756365 0.08468336694118256 0.11393411468574473 0.19178142751465094 0.06504086319439832 0.1665290787807686 1.268755702961663e-07 6.896621992617223 1.6374695211993844 up TENCLSSCVDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TENCLSSCVDR 11 0 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 0 9435250.0 902150.0 3780100.0 4753000.0 False True 1182727.386433027 3216123.814714396 4261205.1539954 1.0 2.7192435480959514 3.602863350316692 20.173686146328635 -8.95905201817787 0.24711010279127743 8.756439013933747e-24 4.231807849276421 0.9991957209053701 0.030648841341222016 0.43893721537659675 0.08230054655810747 0.7532171544545574 0.37339746018482783 1.0988742124834068e-09 8.95905201817787 4.231807849276421 TENCLSSCVDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TENCLSSCVDR 11 0 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 0 26792400.0 2991400.0 21415000.0 2386000.0 False True 4538172.500633781 17593325.9338413 1914406.0541790486 1.0 3.876742440130756 0.42184514888133745 22.113680017708383 -6.685705684818481 1.8815293266182955 2.8107413735079634 0.43432344230428943 0.3504382680450566 1.217741157979339 0.4259834352890899 2.920311353417381 0.5183988608516304 1.3573722898599812 2.0620268460847083e-07 6.685705684818481 -2.376417931203674 TENCLSSCVDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TENCLSSCVDR 11 0 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 0 8082250.0 902150.0 3161300.0 4018800.0 False True 1235699.2346870536 3021623.312978878 3069642.2097840654 1.0 2.4452740830126984 2.484133779172782 20.236896207851526 -10.740432964867843 0.6538115464146887 1.0213538692424983e-10 2.4782679888216492 0.9999284405755324 0.005842401535940188 2.3429206436643977 0.32688665231346303 3.725933488964446 0.0063380559550401065 1.8178876328430766e-11 10.740432964867843 2.478267988719514 TENCLSSCVDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TENCLSSCVDR 11 0 G3XAN8;Q9Y5J9 G3XAN8 TIMM8B Mitochondrial import inner membrane translocase subunit Tim8 B 0 10511600.0 2991400.0 4296800.0 3223400.0 False True 3872426.2693095426 4057679.302809241 2636774.274877017 1.0 1.0478390085740044 0.6809101301100192 21.884806339800832 -6.874099712225437 1.1121136048020699 1.027861289276255 0.6576715340128959 0.9686094988642303 0.028856512166497345 0.1329880762341977 0.30492596126444405 0.020082040895174826 0.047916364070554 1.3362886749435623e-07 6.874099712225437 -0.3701897552633592 TENDHINLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TENDHINLK 9 0 A8MUA9;A8MU27;P55854;P55854-2 A8MUA9 SUMO3 Small ubiquitin-related modifier 3 0 3361830.0 481630.0 1797300.0 1082900.0 False True 631421.5941115546 1529149.8458205278 970851.895910292 1.0 2.421757285593197 1.5375652416137824 19.268244074943475 -10.310977128035953 5.415123140999516 0.9998180583045412 1.9796612636035247 0.6207533957704059 0.3609698903964672 0.0007930343439612648 0.00010090575922895538 0.34957067576591255 0.1165025311656351 4.8867809472278186e-11 10.310977128035953 0.9798432052989835 TENDHINLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TENDHINLK 9 0 A8MUA9;A8MU27;P55854;P55854-2 A8MUA9 SUMO3 Small ubiquitin-related modifier 3 0 2957530.0 481630.0 1163400.0 1312500.0 False True 659701.6265613544 1111997.1411506739 1002514.5317860009 1.0 1.685606183733207 1.5196484159233217 19.331454136466366 -10.095163423059512 4.436459837689891 0.9999537014526237 1.6026272997152566 0.9461813004393753 0.06775197547740927 22221370.8153827 1.6618817278564768 13237.113722249154 0.024447888220682935 8.032238158029895e-11 10.095163423059512 0.6026735982626329 TENLLGSYFPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TENLLGSYFPK 11 0 Q06323;Q06323-3;Q06323-2 Q06323 PSME1 Proteasome activator complex subunit 1 0 23141400.0 4476700.0 10238000.0 8426700.0 False True 5868997.052424472 8710530.307411425 7554785.918614151 1.0 1.4841599390160063 1.2872362775328507 22.484682552877523 -10.150247651795425 4.562545563333281 0.9999589039082585 1.385698108184649 0.8364652791340109 0.08039374838804901 4.186890461078399e-05 7.797668551632818e-06 0.07785122045196065 0.025946970685252306 7.075422009331911e-11 10.150247651795425 0.3857392042763904 TENLLGSYFPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TENLLGSYFPK 11 0 Q06323;Q06323-3;Q06323-2 Q06323 PSME1 Proteasome activator complex subunit 1 0 19288100.0 6397000.0 4073600.0 8817500.0 False True 6193930.736540759 5700209.723543364 6507932.230670091 1.0 0.9202895489152446 1.0506950283245657 22.56242381952954 -6.741265548508798 1.68203899047591 0.9526441995044095 1.0507938327467319 0.6107048287529067 0.03348990421117659 0.31548890140953373 1.753096672611027 0.01574799788911148 0.03859096115526363 1.814405908596575e-07 6.741265548508798 0.0981496332423224 TENLLGSYFPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TENLLGSYFPK 11 0 Q06323;Q06323-3;Q06323-2 Q06323 PSME1 Proteasome activator complex subunit 1 0 44293200.0 8078000.0 30301000.0 5914200.0 False True 12254916.580905171 24893549.807206392 4745255.77771406 1.0 2.031311240909949 0.3872124095163417 23.54685732803897 -6.737141982182131 1.6972679110920417 1.6156614057586307 0.38686366604416017 0.5919648382354499 0.4333528220406474 0.32302933903086883 1.8260355990562787 0.20208380028303866 0.4974391352928524 1.8317154889524767e-07 6.737141982182131 -1.2287977397144705 TENLLGSYFPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TENLLGSYFPK 11 0 Q06323;Q06323-3;Q06323-2 Q06323 PSME1 Proteasome activator complex subunit 1 0 23862900.0 4476700.0 9538800.0 9847400.0 False True 6131856.968268624 9117344.275406612 7521646.933569122 1.0 1.4868814329145978 1.226650747480321 22.547892614400414 -10.16073604623606 4.693802890660415 0.9999589757411682 1.3567660902005212 0.7147783313003152 0.10623873246528528 13084112.951499242 28323353.014943704 3555.869761770192 0.03636834091201102 6.906594425389492e-11 10.16073604623606 0.356807114459353 TENLLGSYFPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TENLLGSYFPK 11 0 Q06323;Q06323-3;Q06323-2 Q06323 PSME1 Proteasome activator complex subunit 1 0 15011500.0 6397000.0 5644400.0 2970100.0 False True 5319388.9351504715 5613992.496874318 3591134.177809206 1.0 1.0553829707350613 0.6751027649208023 22.342829094963815 -6.869916468630391 1.1345936721910206 1.0313042989707166 0.6528723889927169 0.9645968751078005 0.0315619931834839 0.1369320288666062 0.3295168218789143 0.021590673651101563 0.051107325882430804 1.3492223644845202e-07 6.869916468630391 -0.3784319099779997 TENLLGSYFPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TENLLGSYFPK 11 0 Q06323;Q06323-3;Q06323-2 Q06323 PSME1 Proteasome activator complex subunit 1 0 19498900.0 8078000.0 6559100.0 4861800.0 False True 10457130.241185574 6194080.319087713 3977002.2862806586 1.0 0.592330799772602 0.38031488511228173 23.31798365013142 -10.670069240081721 0.12787472330999972 1.9068649126640709 4.464276094280996e-16 0.9997957622961773 0.0036750314003524396 2.635921443895631 0.0703938795100077 0.9701288241009904 0.24150136373426045 2.1376212588537257e-11 10.670069240081721 -1.9068649126640704 TENLNDDEKLNNAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TENLNDDEKLNNAK 14 1 P13796;P13796-2 P13796 LCP1 Plastin-2 0 30590400.0 2915400.0 16029000.0 11646000.0 False True 3822117.6327737574 13637535.680552624 10440983.636320308 1.0 3.5680575510324357 2.731727445223385 21.865940749944038 -10.005893929259338 5.7414471317745965 0.9999957848898022 3.149892498128665 0.8980718124790303 0.34143033596267713 1.8421892287849912e-05 3.190050640347915e-06 0.33058915046334886 0.11019616708906513 9.865204009004818e-11 10.005893929259338 2.1498967132388627 TENLNDDEKLNNAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TENLNDDEKLNNAK 14 1 P13796;P13796-2 P13796 LCP1 Plastin-2 0 26674150.0 7352900.0 4374300.0 14946950.0 False True 7119486.214273971 6120980.801673148 11031895.396111628 1.0 0.8597503552153941 1.54953532657927 22.763341700562975 -6.85375619843086 1.2167976660684385 0.9248432627018234 1.5791795106540112 0.9456001162577545 0.06942770705241881 0.1533715898414336 0.4350923488223739 0.04460034676433371 0.1034888447790629 1.4003732348832228e-07 6.85375619843086 0.6543362479521878 TENLNDDEKLNNAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TENLNDDEKLNNAK 14 1 P13796;P13796-2 P13796 LCP1 Plastin-2 0 129744000.0 10030000.0 109630000.0 10084000.0 False True 15216243.291220432 90065669.95690034 8090892.980025788 1.0 5.9190477066614084 0.5317273669443839 23.859108882835425 -6.666437676827599 1.9497568765115882 4.149312958886357 0.5536760951229394 0.2634864490354285 2.091223406765589 0.46933289909039155 3.4361623469380254 0.8644798223507812 2.3206620011159917 2.1555709553050664e-07 6.666437676827599 -3.595636863763418 TENLNDDEKLNNAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TENLNDDEKLNNAK 14 1 P13796;P13796-2 P13796 LCP1 Plastin-2 0 28365400.0 2915400.0 11563000.0 13887000.0 False True 3993302.1657225904 11052108.426272342 10607176.611742634 1.0 2.767661440985009 2.6562419199808436 21.92915081146693 -10.452426718422325 4.824772648902529 0.9960954147625262 2.711951680483225 0.9968331803963258 0.04548682897528328 0.0019111806206529838 0.00021690354456079927 0.04405892571317209 0.01468081092427486 3.52836318162076e-11 10.452426718422325 1.7158562657206988 TENLNDDEKLNNAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TENLNDDEKLNNAK 14 1 P13796;P13796-2 P13796 LCP1 Plastin-2 0 12738800.0 7352900.0 3345000.0 2040900.0 False True 6114262.138700631 3326979.8210694874 2467642.7539445874 1.0 0.5441343118102748 0.40358798788254063 22.54374697599725 -13.999999999999998 0.1647892166732412 3.269285150652286 0.272473444174457 0.9995245983286696 0.005550667367901666 12.045046570159144 0.12842932178268954 8.735095366603382 0.12025897730170557 1.0000000000000041e-14 13.999999999999998 -2.9968117064778292 TENLNDDEKLNNAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TENLNDDEKLNNAK 14 1 P13796;P13796-2 P13796 LCP1 Plastin-2 0 29585200.0 10030000.0 8558200.0 10997000.0 False True 12984032.720858024 8081928.64673759 8995658.838748697 1.0 0.6224513462411786 0.6928247203426823 23.630235204927875 -10.766877511757672 7.016439996173101 1.0079212828784523 0.6576380332922892 0.9692844532051453 0.028729809671112775 0.0035836885846476803 0.00011906853802922766 0.028002813090801746 0.00927250619966072 1.7104976751463276e-11 10.766877511757672 -0.3502832495861631 TENLNDDEKLNNAK(ub)YAISMAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TENLNDDEKLNNAKYAISMAR 21 2 P13796;P13796-2 P13796 LCP1 Plastin-2 1 38805500.0 9451500.0 15466000.0 13888000.0 True False 14338616.497205403 12705971.46359046 11143030.712673368 1.0 0.8861365018073295 0.7771343012657563 23.773402492371904 -6.971656230991627 0.21498156220046197 1.0535639173433295 0.6066467388084388 0.9999925754324382 0.0002478676469918071 0.07576888154642798 0.00707464919129917 0.0031386426487846997 0.011168643989505397 1.0674407275096227e-07 6.971656230991627 -0.44691717853489077 TENLNDDEKLNNAK(ub)YAISMAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TENLNDDEKLNNAKYAISMAR 21 2 P13796;P13796-2 P13796 LCP1 Plastin-2 1 40601500.0 9451500.0 13686000.0 17464000.0 True False 12235153.06691823 12924362.0690391 14285731.195772216 1.0 1.0563302312894127 1.1675972599311732 23.544528814464353 -6.96028754204838 0.4313624740311717 0.9956436441843876 1.2325603651750554 0.9997807081254535 0.0010311859001000741 0.07959855872107674 0.020752984118524154 0.001452830315151065 0.00923572090823302 1.0957524691316144e-07 6.96028754204838 0.23691672099066785 TENLVDSSVTFK(ub)TTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TENLVDSSVTFKTTSR 16 1 P51809-3;P51809 P51809-3 VAMP7 Vesicle-associated membrane protein 7 1 39116900.0 20095100.0 19021800.0 0.0 True False 26344870.701225206 16183821.58639568 0.0 1.0 0.6143063585293296 0.0 24.651018763294385 -7.61685991422965 0.6725228478078574 0.9970583970507464 3.309756425977802e-21 0.9871678099716051 0.04664715555076925 0.12119760620816206 0.1473279737302076 0.04239797317225845 0.07729536766583125 2.4162400897295446e-08 7.61685991422965 -0.9970583970507464 down TENNDHINLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TENNDHINLK 10 0 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 0 43084600.0 1555800.0 22561800.0 18967000.0 False True 2039668.8663886313 19195667.3852076 17004476.784311127 1.0 9.41116849971574 8.336881081299573 20.959903523680047 -9.60308828187687 7.220959941837936 0.9999998963060026 8.874024791076865 0.986231470994869 0.4385760020437774 5.271445026962471e-09 0.0 0.4246493879866384 0.14154979599554612 2.4940876859104876e-10 9.60308828187687 7.874024894770862 TENNDHINLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TENNDHINLK 10 0 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 0 24498910.0 1738400.0 1336000.0 21424510.0 False True 1683215.4435520486 1869471.7671479606 15812788.109477026 1.0 1.1106550705136473 9.394393433147027 20.68278841589791 -6.909809879298153 0.8970058128050035 0.7419727768175846 10.46066727583827 0.9908501396431537 0.37605126701921077 0.1045445162575921 0.13944169960015934 0.30758886776109295 0.8479948799518409 1.2308074623601392e-07 6.909809879298153 9.718694499020685 up TENNDHINLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TENNDHINLK 10 0 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 0 33751140.0 1555800.0 16965400.0 15229940.0 False True 2131021.303914115 16215812.530924566 11632941.842460107 1.0 7.609408925729867 5.458857600857162 21.02311358520294 -9.922916235896324 8.178039017894104 0.9999999786335165 6.534133263293515 0.8982658942577486 0.8779589019340779 1.429745151557995e-07 1.2391410455184756e-08 0.850080051461285 0.2833600171537694 1.194218415907647e-10 9.922916235896324 5.534133284659998 TENNDHINLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TENNDHINLK 10 0 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 0 7932660.0 1738400.0 1591800.0 4602460.0 False True 1445556.62417783 1583224.6574524373 5564813.106629322 1.0 1.095235310033536 3.8495988421030183 20.463193691332187 -6.914238935767409 0.8663759684188821 0.9257222883033746 4.239810997378847 0.9924251908693695 0.11500927431752313 0.10168106310360549 0.12405829010785777 0.09617951276238731 0.2739816270230874 1.2183191319472745e-07 6.914238935767409 3.314088709075473 up TENNDHINLK(ub)VAGQDGSVVQFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TENNDHINLKVAGQDGSVVQFK 22 1 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 1 23939100.0 9755200.0 5927800.0 8256100.0 True False 9445526.51572651 8294801.45306862 6093579.7323090825 1.0 0.8781724808307966 0.6451286460488422 23.171199787373098 -6.960906339704195 0.42246727201976075 1.0100314266618202 0.5044430381625127 0.9998023469371672 0.0020698593066578556 0.07937894906376332 0.019946778401293372 0.0030196610478317462 0.01938614096295251 1.0941923152197771e-07 6.960906339704195 -0.5055883884993075 TENNDHINLK(ub)VAGQDGSVVQFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TENNDHINLKVAGQDGSVVQFK 22 1 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 1 25055200.0 9755200.0 7758100.0 7541900.0 True False 8111881.028635289 7716305.575437723 9118876.420194346 1.0 0.951235052412484 1.1241383333907784 22.951605062807374 -6.831394442835957 1.3217776558126473 0.9739680634105568 1.1289213359012054 0.9086154585265777 0.022003964785994146 0.17909676420754872 0.611473094313008 0.013069235450486381 0.030073586123091047 1.4743668487075105e-07 6.831394442835957 0.1549532724906486 TENNDHINLK(ub)VAGQDGSVVQFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TENNDHINLKVAGQDGSVVQFK 22 1 P61956-2;P61956 P61956-2 SUMO2 Small ubiquitin-related modifier 2 1 278898000.0 13048000.0 12840000.0 253010000.0 True False 16890893.21453196 12125442.71273287 206964776.10182825 1.0 0.7178686502085533 12.253039165730296 24.009742286140217 -6.901296330033124 0.9530610968837853 0.5373195965352425 13.496129432940858 0.9871995936946291 0.6078349403557861 0.11045653519370509 0.17209766303910412 0.47715249541257965 1.2497066799594407 1.2551732352200124e-07 6.901296330033124 12.958809836405615 up TEPTAQQNLALQLAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEPTAQQNLALQLAEK 16 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 12199500.0 2062000.0 4936800.0 5200700.0 False True 2703301.9684364065 4200248.683495674 4662581.45263705 1.0 1.5537475030675556 1.7247727065185743 21.36629124436107 -11.362197086717469 0.21380711459053936 9.046977183949177e-09 1.8382403746773044 0.9993417171400968 0.007936558523658321 3.7515339528186264 0.1228685422786493 1.8614539097582272 0.09760548588871762 4.343130842836379e-12 11.362197086717469 1.8382403656303272 TEPTAQQNLALQLAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEPTAQQNLALQLAEK 16 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 6993500.0 1711400.0 0.0 5282100.0 False True 1657072.5437729992 0.0 3898559.5503966557 1.0 0.0 2.3526788643302243 20.660205331962377 -6.791216487007693 1.49145214310462 0.44198314935639144 2.378551623511538 0.8052459626049758 0.42545217284638376 0.23354338854910503 1.026258262434104 0.2245168393821274 0.5251907828822586 1.6172736584980513e-07 6.791216487007693 1.9365684741551463 TEPTAQQNLALQLAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEPTAQQNLALQLAEK 16 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 11779000.0 2062000.0 4108400.0 5608600.0 False True 2824377.123454755 3926877.3033380043 4283964.192742831 1.0 1.3903516179647708 1.5167819329674788 21.42950130588396 -12.115406740532066 0.18587559993062705 1.4081219318686147e-11 1.6212571173643415 0.9994461604956936 0.005176377155094527 5.587700722242338 0.12043372847553922 2.226209624300587 0.0891485738658963 7.666431497978641e-13 12.115406740532066 1.6212571173502603 TEQAK(ub)ADLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEQAKADLAR 10 1 Q13442 Q13442 PDAP1 28 kDa heat- and acid-stable phosphoprotein 1 2205170.0 562310.0 743070.0 899790.0 True False 770211.2028563728 710238.7103961082 687278.133756743 1.0 0.9221350037004744 0.8923242497745194 19.55489458197549 -13.999999999999996 0.13301432061102286 1.3703125109846592 0.8521315782972716 0.9996321742971636 0.0008705864825308085 11.933263299085537 0.1137040757146174 1.1523900802827818 0.03578965217707914 1.0000000000000082e-14 13.999999999999996 -0.5181809326873876 TEQAK(ub)ADLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEQAKADLAR 10 1 Q13442 Q13442 PDAP1 28 kDa heat- and acid-stable phosphoprotein 1 2334850.0 716600.0 612750.0 1005500.0 True False 927652.8262977938 578649.923849461 822509.3173012477 1.0 0.623778538096863 0.886656402033326 19.823225452751707 -10.149976388719498 5.449897699277575 1.000005704777304 0.75521747006504 0.536197408205181 0.10731943855304467 7.439031697085932e-06 1.160384091877659e-06 0.10391402076329935 0.034637199853328283 7.079842743064967e-11 10.149976388719498 -0.24478823471226407 TEQDLALGTDAEGQK(ub)VK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEQDLALGTDAEGQKVK 17 1 O00186 O00186 STXBP3 Syntaxin-binding protein 3 1 15787800.0 2731900.0 3791400.0 9264500.0 True False 3536498.4037998053 3580405.2570915422 7578456.061797516 1.0 1.0124153465599082 2.142926475989587 21.753890179466403 -6.909298586756788 0.9004809277775694 0.9642154677721005 2.286863435786627 0.9906545152455476 0.051804457251502664 0.10488431665480219 0.14129043586026027 0.04226638385587247 0.11611759509715959 1.232257338617676e-07 6.909298586756788 1.3226479680145267 up TEQEEDEELLTESSK(ub)ATNVCTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEQEEDEELLTESSKATNVCTR 22 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 1 18731600.0 4380400.0 7361700.0 6989500.0 True False 5742746.819853943 6263363.055681852 6266293.588018274 1.0 1.090656309978358 1.0911666114818634 22.453309528437515 TEQEEDEELLTESSK(ub)ATNVCTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEQEEDEELLTESSKATNVCTR 22 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 1 10246000.0 3728600.0 3496200.0 3021200.0 True False 3610237.633932451 4892250.892442139 2229857.0859427843 1.0 1.3551049511146045 0.6176482858038109 21.783662370983052 -6.7757870381059595 1.5524675049360366 1.202171614388485 0.6125781761725484 0.7521348048349168 0.14992271516522993 0.2571772880152016 1.223990774264422 0.07608800217379366 0.18016469876032667 1.6757644072510528e-07 6.7757870381059595 -0.5895934382159367 TEQEEDEELLTESSK(ub)ATNVCTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEQEEDEELLTESSKATNVCTR 22 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 1 34046900.0 8287700.0 8485200.0 17274000.0 True False 12573046.812028684 6970949.764829808 13859786.328536829 1.0 0.5544359986125775 1.10234110599804 23.583830962973014 -6.690445697798536 1.8649745524134822 0.7207755697867481 1.1004508819476748 0.3724750474679157 0.18842514744808306 0.41569625732477555 2.8036251103885745 0.08081789943754127 0.21032623223078561 2.0396436714086245e-07 6.690445697798536 0.37967531216092676 TEQEEDEELLTESSK(ub)ATNVCTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEQEEDEELLTESSKATNVCTR 22 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 1 16133700.0 4380400.0 6362800.0 5390500.0 True False 5999952.2558589745 6081670.457034143 4117374.920832339 1.0 1.0136198085735382 0.6862346140857551 22.516519589960406 -6.89719419010385 0.9788534733977194 1.014679060627176 0.6537648356448537 0.9851173751036334 0.018448340324906654 0.11349953314299262 0.18930436489992222 0.014206756655350166 0.03646901952754105 1.267085175672227e-07 6.89719419010385 -0.3609142249823224 TEQEEDEELLTESSK(ub)ATNVCTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEQEEDEELLTESSKATNVCTR 22 1 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 1 12103700.0 3728600.0 2965700.0 5409400.0 True False 3100496.104987034 2949723.185454639 6540480.529760318 1.0 0.9513713565742327 2.1094948383389984 21.564067646417328 -6.8970990319759276 0.9794327859085614 0.9479424309554229 2.2241416696531067 0.9850667113689606 0.06535981448791303 0.11357199847175348 0.18971039781891902 0.05031036214892438 0.12909298779082892 1.2673628367262592e-07 6.8970990319759276 1.276199238697684 up TEQGGAHFSVSSLAEGSVTSVGSVNPAENFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEQGGAHFSVSSLAEGSVTSVGSVNPAENFR 31 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 26215200.0 4305800.0 14979000.0 6930400.0 False True 5573942.980007028 14145405.482400749 5669138.311909067 1.0 2.5377736250870138 1.0170786339658464 22.41026681344479 -6.6435428356965325 2.031289563958125 2.002866327587962 1.0233819330158864 0.1685113748281526 0.6573796322884722 0.5244576416470308 4.1399540744889 0.2631264858481668 0.7281415948205632 2.272255505212494e-07 6.6435428356965325 -0.9794843945720757 TEQSVTPEQQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEQSVTPEQQK 11 0 F6U236;Q9BY11 F6U236 PACSIN1 Protein kinase C and casein kinase substrate in neurons protein 1 0 1813980.0 738680.0 0.0 1075300.0 False True 715231.0077329895 0.0 793646.6716914718 1.0 0.0 1.1096368349675305 19.448049758123727 -10.67551548102482 4.2978210955179605 1.0179457094287563 0.5548184174900187 0.17669093931326796 0.4530073409118255 0.07855141012095763 0.005930609713271285 0.4423121631660477 0.14620749058835045 2.1109819456091296e-11 10.67551548102482 -0.4631272919387376 TERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTR 34 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 12107800.0 2301400.0 4990300.0 4816100.0 False True 3017157.6867893045 4245766.69203705 4317776.171293339 1.0 1.4072074226107698 1.4310740834656481 21.52475866786515 -11.812918557615015 0.44952609336072297 7.830932376794193e-13 1.4311548567790597 0.999815566948209 0.00268657778921975 5.177538867949192 0.22414897327385758 4.952659432513595 0.005390993899405858 1.5384431144472987e-12 11.812918557615015 1.4311548567782766 TERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTR 34 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 21928100.0 7637900.0 4492400.0 9797800.0 False True 7395439.04527509 6286238.747556512 7231462.252300478 1.0 0.8500156257217426 0.9778273078892623 22.81820436771531 -10.342913467598722 4.94187065687206 1.0000487142473122 0.9139214668097533 0.3768561779434981 0.05217890074629335 2.802152268507203e-05 3.7258388561319316e-06 0.050550580571983854 0.016840667801137063 4.540320727193597e-11 10.342913467598722 -0.08612724743755895 TERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TERPVNSAALSPNYDHVVLGGGQEAMDVTTTSTR 34 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 0 15571600.0 2301400.0 4950000.0 8320200.0 False True 3152289.772996495 4731292.632538971 6355140.119897827 1.0 1.5009066339867325 2.0160393166700454 21.58796872938804 -6.970774599230246 0.23896159347507379 0.8126320683725511 2.7191942274999037 0.999987809720154 0.0014482797722128727 0.07605214599670779 0.008125433854560759 0.012404648337528204 0.05031352169529767 1.069609867473046e-07 6.970774599230246 1.9065621591273527 TESAVSQMQSVIELGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TESAVSQMQSVIELGR 16 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 1107300.0 0.0 0.0 1107300.0 False True 0.0 0.0 992727.21797162 0.0 TESAVSQMQSVIELGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TESAVSQMQSVIELGR 16 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 1647700.0 0.0 1647700.0 0.0 False True 0.0 1574899.1657847401 0.0 0.0 TESDDLHTFLLEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TESDDLHTFLLEIK 14 0 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A0A0MSW3;A0A494BZU9 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 0 3999300.0 1437800.0 1463900.0 1097600.0 False True 1884969.7236750063 1245491.8262375079 984030.8809226486 1.0 0.6607489821158778 0.5220406824382016 20.846109920481396 -13.999999999999998 0.12299304754048004 2.6140219046051643 0.3093254633649466 0.9996783906120437 0.0036004935081797233 11.95325281390739 0.10830670125470657 4.69804499991246 0.1888233993649609 1.0000000000000041e-14 13.999999999999998 -2.3046964412402176 TESDDLHTFLLEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TESDDLHTFLLEIK 14 0 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A0A0MSW3;A0A494BZU9 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 0 6689900.0 1746000.0 2416100.0 2527800.0 False True 1690574.1857120811 3380861.329795053 1865693.3476255008 1.0 1.9998302105689683 1.1035856121508554 20.689081895233432 -6.619916934602235 2.1172120502774536 1.6634298740086009 1.107005154946152 0.08260693570395217 0.42996449065735365 0.5854850826196554 4.987058171265558 0.16688207006954564 0.4767117467935532 2.399291776029785e-07 6.619916934602235 -0.556424719062449 TESDDLHTFLLEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TESDDLHTFLLEIK 14 0 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A0A0MSW3;A0A494BZU9 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 0 6697400.0 1437800.0 1606800.0 3652800.0 False True 1969393.5150840178 1535806.2630229548 2790083.8717774497 1.0 0.7798371687831188 1.4167223819960735 20.909319982004288 -6.813344494247034 1.4002928434714514 0.8804777979897084 1.4287526302775502 0.8684158140708341 0.09580201482638351 0.20227196683439377 0.7810200616393749 0.053784259521092406 0.12424433331661687 1.5369350178061698e-07 6.813344494247034 0.5482748322878418 TESTPITAVK(ub)QPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TESTPITAVKQPEK 14 1 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 1 7141600.0 3283200.0 2841500.0 1016900.0 True False 4497087.765143864 2715953.1344160605 776729.1637129025 1.0 0.6039359861879805 0.17271825774297614 22.100559609235543 -7.607699369318643 0.40119340434263867 1.0415633020701582 1.3983488255208933e-21 0.998563459944702 0.012804637823860281 0.1209182602171589 0.056891185295600416 0.024034657560537402 0.07204705610190683 2.4677469890092337e-08 7.607699369318643 -1.0415633020701582 down TESTPITAVK(ub)QPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TESTPITAVKQPEK 14 1 Q9Y678 Q9Y678 COPG1 Coatomer subunit gamma-1 1 16408000.0 8107400.0 3176900.0 5123700.0 True False 10495189.120746203 3000102.7222804576 4191239.173601592 1.0 0.28585504155899877 0.3993486087179339 23.32322482808833 -9.972850145450558 5.62497755578587 1.0000009006560906 0.3426018251544678 0.9781351924306433 0.04633355477356473 6.373422347981432e-07 1.1634955365083215e-07 0.0448623463638548 0.0149540905003843 1.0645102671638352e-10 9.972850145450558 -0.6573990755016228 TETITGFQVDAVPANGQTPIQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TETITGFQVDAVPANGQTPIQR 22 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 12131700.0 2178600.0 5238000.0 4715100.0 False True 2856165.697592409 4456510.81756408 4227226.682432931 1.0 1.5603124221121603 1.4800355196465846 21.44564824762696 -10.62987991036129 6.367575505322713 0.9977123951966401 1.5201739708793724 0.9824508498616845 0.03277290819530552 0.0010677957235308841 6.206631417643255e-05 0.03183588130674487 0.010577410637266908 2.3448771231593083e-11 10.62987991036129 0.5224615756827323 TETITGFQVDAVPANGQTPIQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TETITGFQVDAVPANGQTPIQR 22 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 9667500.0 2178600.0 4026200.0 3462700.0 False True 2984087.294451271 3848309.1711370572 2644881.5765450597 1.0 1.2896101190782032 0.8863284869256527 21.50885830914985 -6.713978884182978 1.7811603366432414 1.1773180244907302 0.8871657746379745 0.48393466191714174 0.1219669836627714 0.36712288585903186 2.2727932000382673 0.054445107339323014 0.13764574999696982 1.9320622534654353e-07 6.713978884182978 -0.2901522498527557 TETPPPLASLNVSK(ub)LASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TETPPPLASLNVSKLASK 18 1 Q3MHD2-2;Q3MHD2;K7ELG9 Q3MHD2-2 LSM12 Protein LSM12 homolog 1 8090900.0 2686500.0 3226800.0 2177600.0 True False 2233943.7821293985 3209416.5879303487 2632926.091915201 1.0 1.4366595138178133 1.178599977751227 21.091161449745385 -10.246750393604739 4.816536001729218 0.9999275653326778 1.3076297457849846 0.6545489243143019 0.10535236443897604 74399878.98366046 7.614567727087707 59771.978512706075 0.036064916555797785 5.665648229270358e-11 10.246750393604739 0.3077021804523068 TETQEK(ub)NPLPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TETQEKNPLPSK 12 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 1 7005300.0 3067000.0 2293900.0 1644400.0 True False 4200952.782558549 2192547.913087102 1256026.5874810682 1.0 0.5219168190106989 0.29898612350412984 22.00228513978287 -10.879011175534348 0.150205634424122 1.9583456074382126 5.590805161512182e-23 0.9996629886211609 0.00536854334133531 2.967029600106215 0.08503573472130863 1.2016172558024922 0.20505806345855412 1.3212616342271594e-11 10.879011175534348 -1.9583456074382126 TETQEK(ub)NTLPTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TETQEKNTLPTK 12 1 P63313;CON__P21752 P63313 TMSB10 Thymosin beta-10 1 3426780.0 948280.0 1468700.0 1009800.0 True False 1243204.2631565845 1249575.6849477615 905315.5826855779 1.0 1.0051249999537482 0.7282114528685069 20.245631925434942 -6.902683984006219 0.9441366037248796 1.0106806243406692 0.6975061604029164 0.9878551624029325 0.014254533535927219 0.10945676616577062 0.16648393928296948 0.011263725532013621 0.02972158619174963 1.2511691169213848e-07 6.902683984006219 -0.31317446393775283 TETQEK(ub)NTLPTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TETQEKNTLPTK 12 1 P63313;CON__P21752 P63313 TMSB10 Thymosin beta-10 1 2925590.0 948280.0 1261200.0 716110.0 True False 1298884.742303432 1205476.0137693232 546979.5667483984 1.0 0.9280854370739174 0.4211147832704456 20.308841986957834 -6.932527224779903 0.7257473480744279 1.0070328887849682 0.31000519956040634 0.9970120526688937 0.014081894523303697 0.09134666783841242 0.07140603058421092 0.013027848769438462 0.04525151668196739 1.1680805036686856e-07 6.932527224779903 -0.6970276892245619 down TETQEK(ub)NTLPTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TETQEKNTLPTK 12 1 P63313;CON__P21752 P63313 TMSB10 Thymosin beta-10 1 4043430.0 1623700.0 1923400.0 496330.0 True False 1350178.4921062724 1913038.2624349936 600110.3082293669 1.0 1.4168780451025127 0.44446738837707117 20.364718711899954 -6.7902284926151415 1.4955565418928187 1.2329288202145632 0.4340827356575807 0.8020000684036901 0.17724470968778694 0.2350251361768568 1.0385125546727536 0.0932853946771181 0.21835480673112218 1.6209570490709987e-07 6.7902284926151415 -0.7988460845569825 down TETQEK(ub)NTLPTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TETQEKNTLPTK 12 1 P63313;CON__P21752 P63313 TMSB10 Thymosin beta-10 1 4363200.0 1564200.0 1695600.0 1103400.0 True False 2024887.7349916378 1601238.3694478106 902592.5218400755 1.0 0.7907788376496948 0.445749414272492 20.949410492797682 -6.963634455209826 0.38076172815644854 1.0234981461660448 0.20081421394809304 0.9998821697017924 0.002480622999637215 0.07842744539639061 0.016512971436213685 0.004486763326151547 0.02914406772792951 1.0873404508250633e-07 6.963634455209826 -0.8226839322179518 down TETQEKNPLPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TETQEKNPLPSK 12 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 0 12255900.0 3899400.0 2187000.0 6169500.0 False True 3775615.6814236487 3060280.505054333 4553522.868967297 1.0 0.8105381382197278 1.2060345260697527 21.848280490082686 -6.776420385236098 1.5496176607099357 0.8922237915785487 1.2088338194500634 0.7545889532991777 0.08000939901262588 0.2561755197775317 1.2147472437218054 0.040675357832985926 0.09627589375673638 1.6733223613513928e-07 6.776420385236098 0.3166100278715147 TETQEKNPLPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TETQEKNPLPSK 12 1 P62328 P62328 TMSB4X Thymosin beta-4;Hematopoietic system regulatory peptide 0 26532200.0 12300900.0 8795800.0 5435500.0 False True 15923757.536989298 8306305.997870403 4446294.772939758 1.0 0.5216297710245641 0.27922396850187275 23.924677473732196 -9.70603841844378 0.17730733939619478 1.588968213122378 5.027800046065369e-13 0.9996128797146797 0.005892094152284297 1.1629603063818088 0.07475330488446197 0.5058190258450929 0.16357389448951243 1.9677122147691143e-10 9.70603841844378 -1.5889682131218752 TETVEEPMEEEEAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TETVEEPMEEEEAAK 15 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 9565040.0 764140.0 5418900.0 3382000.0 False True 1001794.9399422873 4610421.242706755 3032063.0824347665 1.0 4.602160640751848 3.026630462527033 19.93415579901066 -9.460179309069314 11.437251712141581 1.0000077459968142 3.81439555163944 0.8096894284528455 0.6432075018500532 0.0 0.0 0.622782985698208 0.2075943285660693 3.4659372123612327e-10 9.460179309069314 2.814387805642626 TETVEEPMEEEEAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TETVEEPMEEEEAAK 15 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 9009610.0 2035200.0 989810.0 5984600.0 False True 1970593.6900121544 1385046.2947909622 4417053.725848392 1.0 0.7028573682190261 2.241483745855873 20.910198912000983 -6.856642073342475 1.2025976663640623 0.8400140788570399 2.3113488982063326 0.9494278941134682 0.1498643885976654 0.15029811648165808 0.41496776079473113 0.09732013242705381 0.22638151705287846 1.391098642009904e-07 6.856642073342475 1.4713348193492926 up TETVEEPMEEEEAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TETVEEPMEEEEAAK 15 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 8716440.0 764140.0 4296300.0 3656000.0 False True 1046663.2081070405 4106475.2600357975 2792528.097683518 1.0 3.9233969707052463 2.6680292916132875 19.997365860533552 -9.721014897484977 6.775821854090481 0.9999999956247755 3.295713131159834 0.8168144113419575 0.5125017088949239 3.803290159620686e-08 8.730297938326558e-09 0.4962276421651261 0.16540921528743766 1.901013068872843e-10 9.721014897484977 2.295713135535059 TETVEEPMEEEEAAKEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TETVEEPMEEEEAAKEEK 18 1 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 23701100.0 1507100.0 10944000.0 11250000.0 False True 1975822.6947771609 9311197.859377887 10085957.917620074 1.0 4.712567521362554 5.1046877557794215 20.914022058330435 -9.894631856880242 0.5500061047394269 1.8062264156919628e-23 5.076946200091277 0.9992689060569724 0.050007780159945524 1.1695100918325698 0.25353798652126247 2.1502564989189166 0.07284602433588289 1.2745830628784434e-10 9.894631856880242 5.076946200091277 TETVEEPMEEEEAAKEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TETVEEPMEEEEAAKEEK 18 1 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 21976800.0 7319100.0 2217700.0 12440000.0 False True 7086759.176772782 3103239.1751527195 9181590.80799954 1.0 0.43789256806182236 1.2955979706623413 22.756694593332146 -6.7298681697236695 1.7234716853635843 0.6616868483037939 1.2951008358190148 0.558795428368152 0.23629846033384977 0.33646725580587283 1.9578656379423112 0.10864866521637591 0.26966915564576627 1.862652459809894e-07 6.7298681697236695 0.6334139875152209 TETVEEPMEEEEAAKEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TETVEEPMEEEEAAKEEK 18 1 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 17595800.0 1507100.0 8054400.0 8034300.0 False True 2064315.5978461003 7698529.975660995 6136763.811602491 1.0 3.729337696083687 2.972783724545592 20.977232119853326 -10.12792481981452 5.692948722466319 0.9999744974366126 3.351060710314848 0.9279339881151099 0.30886186552481115 9.997472323929858e-05 1.5315958925804503e-05 0.29905742534866575 0.09968473845457163 7.448609047044332e-11 10.12792481981452 2.3510862128782355 TETVEEPMEEEEAAKEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TETVEEPMEEEEAAKEEK 18 1 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 7937000.0 7319100.0 0.0 617900.0 False True 6086155.941106741 0.0 747100.0331531963 1.0 0.0 0.12275400768277708 22.537099868766422 -10.836198793820698 2.7798992657083184 1.328955673660792 0.061377001751701195 0.9873347205389589 0.05011412054707642 28753352.875804853 20628647.80825481 63103030.3520591 0.02074097781015833 1.458146655896995e-11 10.836198793820698 -1.2675786719090907 TETVQK(ub)LCPGGQLPFLLYGTEVHTDTNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TETVQKLCPGGQLPFLLYGTEVHTDTNK 28 1 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 1 17860300.0 8452100.0 4265100.0 5143100.0 True False 10941410.065799022 4027743.4356757835 4207108.572662397 1.0 0.368119228824612 0.3845124666164464 23.383295340536325 -9.751954982359157 6.354002356319893 1.0000000073262978 0.37631584777420557 0.9994821110177989 0.00669251130556314 6.980592581076507e-10 1.3676973413430283e-10 0.006479996206857648 0.0021599987356192424 1.770292451920983e-10 9.751954982359157 -0.6236841595520922 TEVNSGFFYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEVNSGFFYK 10 0 P40227;J3KRI6;P40227-2;Q92526;Q92526-2 P40227;P40227-2;Q92526 CCT6A;CCT6B T-complex protein 1 subunit zeta;T-complex protein 1 subunit zeta-2 0 60164000.0 13791000.0 25008000.0 21365000.0 False True 18080134.55223398 21276903.88042049 19154354.747551378 1.0 1.1768111470050713 1.0594143916470282 24.10790207853092 -10.327047786250343 4.7333518103512855 0.999922913687937 1.1181127693261854 0.5744041851996993 0.047927024681391824 3.901317996187304e-05 5.546557574339163e-06 0.04643539605620019 0.01546838070195908 4.709255067142119e-11 10.327047786250343 0.11818985563824846 TEVNSGFFYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEVNSGFFYK 10 0 P40227;J3KRI6;P40227-2;Q92526;Q92526-2 P40227;P40227-2;Q92526 CCT6A;CCT6B T-complex protein 1 subunit zeta;T-complex protein 1 subunit zeta-2 0 42445800.0 12677000.0 7075800.0 22693000.0 False True 12274575.574038982 9901203.839809537 16749022.524592716 1.0 0.8066432749618502 1.3645296673244893 23.549169804611765 -6.813113849257752 1.4014624288973152 0.8950025554790999 1.3749944454467178 0.8677804268782717 0.08410608911095659 0.2025909667074739 0.783638959325807 0.04718109184301446 0.10899080555816043 1.5377514695973125e-07 6.813113849257752 0.4799918899676179 TEVNSGFFYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEVNSGFFYK 10 0 P40227;J3KRI6;P40227-2;Q92526;Q92526-2 P40227;P40227-2;Q92526 CCT6A;CCT6B T-complex protein 1 subunit zeta;T-complex protein 1 subunit zeta-2 0 94318000.0 16820000.0 65002000.0 12496000.0 False True 25517169.706712637 53401885.237055965 10026160.122808635 1.0 2.0927824618028805 0.39291818951892293 24.60496498247839 -6.7331329554617465 1.7119804746944263 1.6553468712146415 0.39338041878713254 0.5736020570973055 0.4592789839781299 0.3304229623672292 1.8986518583559955 0.21248193793787257 0.525364771585431 1.848702568195299e-07 6.7331329554617465 -1.261966452427509 TEVNSGFFYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEVNSGFFYK 10 0 P40227;J3KRI6;P40227-2;Q92526;Q92526-2 P40227;P40227-2;Q92526 CCT6A;CCT6B T-complex protein 1 subunit zeta;T-complex protein 1 subunit zeta-2 0 42887000.0 13791000.0 13570000.0 15526000.0 False True 18889905.387761645 12970432.530010894 11859078.568007197 1.0 0.6866330065588445 0.627799786424046 24.17111214005381 -13.999999999999998 0.2352133640050096 3.0271223796845064 0.6005774903670247 0.9995173389651164 0.0035890513753028524 13.459359711548418 0.153527616198215 12.779914655224527 0.029579668911391813 1.0000000000000041e-14 13.999999999999998 -2.4265448893174817 TEVNSGFFYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEVNSGFFYK 10 0 P40227;J3KRI6;P40227-2;Q92526;Q92526-2 P40227;P40227-2;Q92526 CCT6A;CCT6B T-complex protein 1 subunit zeta;T-complex protein 1 subunit zeta-2 0 27706300.0 12677000.0 11714000.0 3315300.0 False True 10541487.18632213 11650894.356953053 4008513.901784741 1.0 1.1052419977392192 0.3802607574181656 23.32957508004604 -6.870039004001823 1.1338340479843652 1.0595403087862028 0.3377606928563037 0.9647249424476529 0.060073587524940235 0.13682036018427923 0.3287151622383062 0.041116404228327685 0.09735542935752428 1.3488417376305275e-07 6.870039004001823 -0.721779615929899 down TEVNSGFFYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEVNSGFFYK 10 0 P40227;J3KRI6;P40227-2;Q92526;Q92526-2 P40227;P40227-2;Q92526 CCT6A;CCT6B T-complex protein 1 subunit zeta;T-complex protein 1 subunit zeta-2 0 41640000.0 16820000.0 13281000.0 11539000.0 False True 21773821.5717679 12541900.675062716 9439020.400138322 1.0 0.5760082415355436 0.43350315740517625 24.37609130457084 -13.999999999999998 0.15228876219599485 3.0577403488882644 0.2807711752726199 0.999558780371157 0.005053855399732883 11.967029120277996 0.12301501813960082 7.282463714688128 0.13797864854365313 1.0000000000000041e-14 13.999999999999998 -2.7769691736156443 TEVNSGFFYK(ub)SAEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEVNSGFFYKSAEER 15 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 20538100.0 0.0 12797000.0 7741100.0 True False 0.0 10887737.48231531 6940125.2298745625 0.0 TEVNSGFFYK(ub)SAEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEVNSGFFYKSAEER 15 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 46565000.0 21612000.0 10939000.0 14014000.0 True False 20925938.889810707 15306999.746131409 10343312.989011692 1.0 0.7314844904562308 0.49428190742008116 24.318789018231424 -6.972586142788975 0.18633823504804808 1.168661886037739 0.05064898313155752 0.9999961567174267 0.00040496474412553106 0.07547216349353986 0.0059191738249990975 0.008641791343395253 0.02612588253684948 1.0651575675357741e-07 6.972586142788975 -1.1180129029061814 down TEVNSGFFYK(ub)SAEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEVNSGFFYKSAEER 15 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 26753900.0 0.0 0.0 26753900.0 True False 0.0 0.0 20435179.833866272 0.0 TEVNSGFFYK(ub)SAEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEVNSGFFYKSAEER 15 1 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 1 27596000.0 21612000.0 0.0 5984000.0 True False 17971335.57393656 0.0 7235226.733110098 1.0 0.0 0.4025981654698603 24.0991942936657 -10.70950758100966 6.700969175247641 1.0090324057364148 0.20129908273493743 0.8399394018996014 0.16436001279695792 0.02200168594313166 0.0009537897618062924 0.15786966725123797 0.05304696602875466 1.952056658801352e-11 10.70950758100966 -0.8077333230014774 TEVQGEDGQVVLIK(ub)QEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEVQGEDGQVVLIKQEK 17 1 P05423 P05423 POLR3D DNA-directed RNA polymerase III subunit RPC4 1 2190800.0 0.0 2190800.0 0.0 True False 0.0 3065597.864871075 0.0 0.0 TEVSFTLNEDLANIHDIGGKPASVSAPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEVSFTLNEDLANIHDIGGKPASVSAPR 28 1 P13984 P13984 GTF2F2 General transcription factor IIF subunit 2 0 43735200.0 6617200.0 21825000.0 15293000.0 False True 10038776.182120044 17930158.230496682 12270331.84683998 1.0 1.7860900477522244 1.2222935967727355 23.259080066607485 -10.561536013182497 6.552611377273201 0.9993246768262393 1.5041918222624786 0.5160467609669213 0.23016893728196947 0.002273582455382989 0.00015213545695200154 0.22313537180862572 0.07428670507561058 2.7445047503299307e-11 10.561536013182497 0.5048671454362393 TEVSLTLTNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEVSLTLTNK 10 0 P46940;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 9892500.0 4346800.0 4128600.0 1417100.0 False True 4208813.213318019 5777171.510364575 1045918.9979112672 1.0 1.3726367072037726 0.24850686996553992 22.004982053771645 -6.81735064419825 1.3832849426341793 1.2013963589524117 0.22532736149351504 0.8782028901150642 0.163165746712882 0.19693281129989934 0.7411458904907577 0.09270960128471886 0.2138477382333407 1.5228227483469607e-07 6.81735064419825 -0.9760689974588966 down TEVSLTLTNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEVSLTLTNK 10 0 P46940;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 27374100.0 5343100.0 13468000.0 8563000.0 False True 8105873.332933203 11064530.17403572 6870519.296703778 1.0 1.3650016129763396 0.8475976633868274 22.950536200497613 -6.717167918581397 1.7696698788055834 1.222731811232748 0.8485378762338467 0.49907159391935985 0.15364950752781495 0.36083585525634615 2.2069317958142936 0.06898374466798343 0.17374379293270653 1.9179270368964905e-07 6.717167918581397 -0.3741939349989014 TEVSLTLTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEVSLTLTNK 10 0 P46940;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 13594900.0 3696200.0 6016500.0 3882200.0 False True 5062785.026049211 5750671.136095097 2965304.3164187535 1.0 1.135871088048683 0.5857061481302427 22.271499795733227 -6.8413660515078645 1.276059872503798 1.0722710305207876 0.5671184578027113 0.9267757209673818 0.06331893909602256 0.16720757354617116 0.5282972801117184 0.03890038487576208 0.08965319848776777 1.4409003554470556e-07 6.8413660515078645 -0.5051525727180763 TEVSLTLTNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEVSLTLTNK 10 0 P46940;H0YLE8 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 18762400.0 5343100.0 9034100.0 4385200.0 False True 6916748.278246922 8531344.393387862 3587138.5959516927 1.0 1.2334328285762288 0.518616328316182 22.721662522590062 -6.8187560006032895 1.377249339264515 1.1259824301403587 0.5034252178980952 0.8814845119468652 0.10245791623495695 0.19511323889314391 0.7275494206307455 0.05846466001279531 0.13479830671923818 1.5179029303919763e-07 6.8187560006032895 -0.6225572122422635 TEVVK(ub)NNLNPVWRPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEVVKNNLNPVWRPFK 16 2 O75131;A0A087WYQ3 O75131 CPNE3 Copine-3 1 8604900.0 1994600.0 2355100.0 4255200.0 True False 1931282.5147888416 3295503.711684254 3140635.4667363088 1.0 1.7063809600350317 1.6261916331177952 20.881127791547524 -10.26000906446876 5.590109112663924 0.9999513569590633 1.6662862965764247 0.9892531767982613 0.0327371556274729 1.984838148025199e-05 2.6273887551247116e-06 0.03169991612050678 0.010565871545607708 5.495294041192168e-11 10.26000906446876 0.6663349396173613 TEVVK(ub)NNLNPVWRPFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEVVKNNLNPVWRPFK 16 2 O75131;A0A087WYQ3 O75131 CPNE3 Copine-3 1 7088200.0 1994600.0 3314400.0 1779200.0 True False 1658598.2757622555 3296544.669343113 2151222.49390867 1.0 1.9875485929997685 1.2970123780696774 20.6615330669818 -10.49745594020725 5.182421146703236 0.9984029086248077 1.6422804855347315 0.5356383229134803 0.28191022924862635 0.0052130818497346625 0.0005055171174011007 0.27353694820266156 0.09098613525044941 3.180856374363084e-11 10.49745594020725 0.6438775769099238 TEVVK(ub)NNLNPVWRPFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEVVKNNLNPVWRPFK 16 2 O75131;A0A087WYQ3 O75131 CPNE3 Copine-3 1 16108600.0 4963200.0 3999400.0 7146000.0 True False 6424960.239298373 3776829.8742448487 5845501.324151878 1.0 0.5878370812544189 0.9098112838734432 22.615256095577063 -9.829851091414472 6.208123161569681 1.0000000136631009 0.7488241825638058 0.4479506292171437 0.1314454177931298 2.488823063243684e-08 4.5822859771148815e-09 0.1272714860977862 0.04242382617060655 1.479615623951362e-10 9.829851091414472 -0.2511758310992951 TEWLDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEWLDGK 7 0 P62937;P0DN26;A0A0H2UH34;A0A0B4J2A2;A0A075B767;A0A075B759;Q9Y536;F5H284;P0DN37;P62937-2 P62937;P62937-2 PPIA;PPIAL4C;PPIAL4E;PPIAL4A;PPIAL4D Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C;Peptidyl-prolyl cis-trans isomerase A-like 4D 0 240109000.0 52657000.0 84742000.0 102710000.0 False True 69033836.93111344 72098823.92172882 92082554.46388961 1.0 1.044398328803219 1.3338756551482966 26.040800336350024 -6.934101702866178 0.7123127461173228 0.996196463863196 1.4000295221431085 0.9972848930812533 0.007713846743716385 0.09056302452232683 0.06765017590584375 0.007207836142592402 0.025627642571511466 1.1638534468726918e-07 6.934101702866178 0.40383305827991245 TEWLDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEWLDGK 7 0 P62937;P0DN26;A0A0H2UH34;A0A0B4J2A2;A0A075B767;A0A075B759;Q9Y536;F5H284;P0DN37;P62937-2 P62937;P62937-2 PPIA;PPIAL4C;PPIAL4E;PPIAL4A;PPIAL4D Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C;Peptidyl-prolyl cis-trans isomerase A-like 4D 0 244492000.0 87551000.0 45511000.0 111430000.0 False True 84771741.4279944 63683779.636729755 82243140.17165501 1.0 0.7512383084736217 0.9701716490218949 26.337080088245187 -10.237698811571697 6.974222620678361 1.000000672167357 0.8607049788650767 0.3505404933606362 0.08937916200437526 9.341434999173138e-07 1.0225288010091685e-07 0.0865414192947729 0.02884700049507668 5.784971029955415e-11 10.237698811571697 -0.13929569330228042 TEWLDGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEWLDGK 7 0 P62937;P0DN26;A0A0H2UH34;A0A0B4J2A2;A0A075B767;A0A075B759;Q9Y536;F5H284;P0DN37;P62937-2 P62937;P62937-2 PPIA;PPIAL4C;PPIAL4E;PPIAL4A;PPIAL4D Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C;Peptidyl-prolyl cis-trans isomerase A-like 4D 0 671940000.0 129300000.0 442480000.0 100160000.0 False True 196157553.09619176 363515986.8879801 80363332.09831254 1.0 1.85318373496288 0.4096876762064011 27.547437646920862 -6.746564588614908 1.6627423523007687 1.5037375387289527 0.40757532944871966 0.6340326380676058 0.35846636476677257 0.30604827970369425 1.6636934338507103 0.17039244538042955 0.41514020005962876 1.792401965120819e-07 6.746564588614908 -1.096162209280233 TEWLDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEWLDGK 7 0 P62937;P0DN26;A0A0H2UH34;A0A0B4J2A2;A0A075B767;A0A075B759;Q9Y536;F5H284;P0DN37;P62937-2 P62937;P62937-2 PPIA;PPIAL4C;PPIAL4E;PPIAL4A;PPIAL4D Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C;Peptidyl-prolyl cis-trans isomerase A-like 4D 0 174444000.0 87551000.0 56031000.0 30862000.0 False True 72802535.66693123 55729149.88171734 37315101.51023458 1.0 0.7654836383265006 0.5125522231938421 26.117485363679464 -6.970160858623947 0.25431535724301746 1.0761253127475396 0.19446152984725396 0.9999836093529276 0.0008058285550351025 0.07625056945909056 0.008843227119290241 0.0054803267333762146 0.024073861861842193 1.0711224979760618e-07 6.970160858623947 -0.8816637829002857 TEWLDGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEWLDGK 7 0 P62937;P0DN26;A0A0H2UH34;A0A0B4J2A2;A0A075B767;A0A075B759;Q9Y536;F5H284;P0DN37;P62937-2 P62937;P62937-2 PPIA;PPIAL4C;PPIAL4E;PPIAL4A;PPIAL4D Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase A-like 4A/B/C;Peptidyl-prolyl cis-trans isomerase A-like 4D 0 386890000.0 129300000.0 144240000.0 113350000.0 False True 167381398.88404223 136212917.2028499 92721463.06921558 1.0 0.8137876616577622 0.553953209182167 27.31856396901331 -6.966431093772408 0.3325785956182337 1.0307192720494895 0.32848268664973396 0.9999396757352373 0.00142072572697046 0.07747863977006281 0.013165710724718015 0.0037573492695197734 0.02261684837258182 1.0803610200132145e-07 6.966431093772408 -0.7022365853997556 TEWLDGK(ub)HVVFGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEWLDGKHVVFGK 13 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 1 39925900.0 13044000.0 17958400.0 8923500.0 True False 17100810.318275698 15279076.721294932 8000181.820256251 1.0 0.8934709196187112 0.4678247212476492 24.027561352741426 -6.944900123265137 0.6122825602731574 1.0046936783126048 0.3343486818167536 0.9987378157460471 0.008168117103678003 0.08560058793696841 0.04495227566523478 0.008284859609790326 0.03592062404392046 1.1352718694391178e-07 6.944900123265137 -0.6703449964958512 down TEWLDGK(ub)HVVFGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEWLDGKHVVFGK 13 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 1 84796900.0 30111700.0 21490200.0 33195000.0 True False 29155820.56581127 30071348.929912534 24500233.671346046 1.0 1.0314012209683727 0.84032049847623 24.797280590970804 -6.864713939264934 1.1616008017661736 1.0173035567150548 0.8301947185983843 0.9591218365517447 0.016915268859651934 0.14202918606876236 0.3615061906357102 0.011333344276911997 0.026613809346863297 1.3654822551790208e-07 6.864713939264934 -0.18710883811667045 TEWLDGK(ub)HVVFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEWLDGKHVVFGK 13 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 1 106076400.0 28000400.0 21916000.0 56160000.0 True False 42478653.903438576 18004918.56951045 45059951.384197615 1.0 0.4238580302106273 1.0607669321779072 25.340234713837518 -6.6684590494708935 1.942675502108244 0.6317690630732093 1.0581850950188536 0.2723081813731555 0.24481901040379278 0.46466435771294223 3.3793079788848837 0.1015041744861252 0.27175564807533653 2.1455614157220076e-07 6.6684590494708935 0.42641603194564426 TEWLDGK(ub)HVVFGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEWLDGKHVVFGK 13 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 1 50608300.0 13044000.0 18233400.0 19330900.0 True False 17866719.300845698 17427788.098209325 14765339.55238249 1.0 0.9754330274492198 0.8264158239550778 24.090771414264317 -6.935608082990673 0.6992609736732358 1.0018654692881561 0.7909449463653857 0.9975296704276063 0.0038119947814624056 0.08982929491745788 0.06417721111115997 0.00359707990623556 0.013092896016106215 1.1598235346159752e-07 6.935608082990673 -0.21092052292277041 TEWLDGK(ub)HVVFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEWLDGKHVVFGK 13 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 1 78673700.0 30111700.0 26655800.0 21906200.0 True False 25039212.72449128 26512199.914637987 26486685.137175173 1.0 1.0588272165884014 1.0578082237892446 24.57768586640508 -10.085706676363449 5.635486274980334 0.9999995895002137 1.058317720188835 0.9997710257699 0.0004160020682927404 2.145390222542242e-09 3.4827613545600266e-10 0.0004027951095928008 0.00013426409020103237 8.209057990742869e-11 10.085706676363449 0.05831813068862124 TEWLDGK(ub)HVVFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEWLDGKHVVFGK 13 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 1 121605400.0 28000400.0 20310000.0 73295000.0 True False 36247069.77040013 19179730.64607515 59956062.07020871 1.0 0.5291387901853957 1.654094039876561 25.111361035929967 -6.793007253873239 1.4842165749825975 0.7378551842919822 1.6670826016794025 0.8109309737859589 0.20057725070904792 0.23090449396447124 1.004764516751138 0.10635124677490797 0.24846867582102236 1.6106187333358892e-07 6.793007253873239 0.9292274173874203 TEYDAVAEK(ub)AGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEYDAVAEKAGK 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 4441720.0 827990.0 922030.0 2691700.0 True False 801705.910668812 1290201.3873229309 1986663.020730898 1.0 1.6093200388738538 2.4780446224645543 19.61271358514495 -6.966087409731626 0.33887113241543965 0.904533645723309 3.211651825933662 0.9999338378234942 0.00493326762286746 0.07759385901939429 0.01356941454033494 0.012306037050553277 0.07525435007484625 1.0812163147787118e-07 6.966087409731626 2.3071181802103533 TEYDAVAEK(ub)AGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEYDAVAEKAGK 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 2107550.0 483360.0 759920.0 864270.0 True False 662071.254312846 726344.2216806099 660147.2261993813 1.0 1.0970786255241844 0.9970939259166876 19.336626967469066 -6.6529446322419465 1.9983738833210418 1.0628496243920047 0.9975174569926798 0.20588844134290962 0.04140491862659229 0.5013915062220392 3.841389715171035 0.0167855653246853 0.045859308458402116 2.2235933562179551e-07 6.6529446322419465 -0.0653321673993249 TEYDAVAEK(ub)AGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TEYDAVAEKAGK 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 4771990.0 827990.0 2270500.0 1673500.0 True False 688510.3711763709 2258268.365841037 2023421.1126102526 1.0 3.2799336950910685 2.9388389737006984 19.393118860579225 -9.8178446616484 5.922101208995465 0.9999997895214953 3.1093863344000425 0.9807662260746648 0.13925133690864444 3.8717758352174484e-07 7.735070034568183e-08 0.1348295432613686 0.04494317572986358 1.5210914961044955e-10 9.8178446616484 2.1093865448785474 TEYDAVAEK(ub)AGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEYDAVAEKAGK 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 41645200.0 2376900.0 6885700.0 32382600.0 True False 3076943.905703635 6502504.741983245 26489299.07353491 1.0 2.1132997354712106 8.60896392177723 21.553066712150375 -6.936429361166531 0.6919836129207998 0.920664250729517 10.19076818340505 0.9976578145894675 0.1623892074824364 0.08943405160608595 0.062314569233537835 0.15408468867407935 0.5684180443281321 1.1576323079033548e-07 6.936429361166531 9.270103932675532 TEYFAQHEQGAAAGAADISTLDQK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TEYFAQHEQGAAAGAADISTLDQKLR 26 1 Q99871-3;Q99871;Q99871-2;H7BZF8 Q99871-3 HAUS7 HAUS augmin-like complex subunit 7 1 101908100.0 4406700.0 26285400.0 71216000.0 True False 5704560.019043379 24822594.38327641 58255418.73786738 1.0 4.351360017321548 10.21207920389914 22.443684188034034 -6.962582812873808 0.39736339841622215 0.6683088298068008 14.108217875754207 0.9998543186330802 0.04595042661365662 0.07879110681821513 0.017814677079034863 0.0754462815849091 0.4915237315996374 1.0899766318031564e-07 6.962582812873808 13.439909045947406 TEYMAFPK(ub)PFESSSSIGAEKPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TEYMAFPKPFESSSSIGAEKPR 22 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 28011200.0 11652000.0 12430000.0 3929200.0 True False 15275884.83812852 10575492.451760514 3522644.0755478055 1.0 0.692299828378134 0.23060163865305572 23.86475261313331 -7.2287056211318355 0.41571132290140317 1.0258998162779258 1.0384838976884466e-11 0.9995622408565056 0.00661566705445356 0.09228588102312821 0.029064743775947463 0.009902799261802585 0.04700051259627038 5.9060127319925626e-08 7.2287056211318355 -1.025899816267541 down TEYMAFPK(ub)PFESSSSIGAEKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEYMAFPKPFESSSSIGAEKPR 22 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 39735400.0 20730700.0 13585000.0 5419700.0 True False 20072615.275911488 19009561.344839092 4000117.9824851397 1.0 0.9470395901849356 0.19928235197560704 24.25872526296393 -6.921181889965519 0.815917234044114 1.0158066215770347 0.07536133007793432 0.9945028573914731 0.027107976343018137 0.09748147355073805 0.10204876602068791 0.02350360779098387 0.07121953572017387 1.198997037488062e-07 6.921181889965519 -0.9404452914991004 down TEYMAFPK(ub)PFESSSSIGAEKPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TEYMAFPKPFESSSSIGAEKPR 22 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 96192900.0 50692000.0 24214000.0 21286900.0 True False 76903470.08160995 19892822.515154496 17079534.884620275 1.0 0.25867262548808573 0.22209056192777096 26.196545361964056 -13.448434373513269 0.4341570402575315 9.999999871830541 0.22149227300170168 0.9998728224707141 0.004041767761733739 19.68528276426526 0.22125221495992659 166.01094203782273 0.00857288750549721 3.560947956581203e-14 13.448434373513269 -9.77850759882884 TEYMAFPK(ub)PFESSSSIGAEKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEYMAFPKPFESSSSIGAEKPR 22 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 37929800.0 11652000.0 20094000.0 6183800.0 True False 15960059.28346014 19206180.638027906 4723313.799358686 1.0 1.2033903068224698 0.2959458806179743 23.9279626746562 -6.847849924381171 1.2453114762035227 1.1083766142674532 0.26112641754178595 0.9371269284676583 0.09749060901945779 0.1598442437937431 0.47808396993099433 0.061288602953177215 0.14165370420916726 1.4195479786147293e-07 6.847849924381171 -0.8472501967256671 down TEYMAFPKPFESSSSIGAEK(ub)PR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TEYMAFPKPFESSSSIGAEKPR 22 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 19467500.0 7411500.0 7961200.0 4094800.0 True False 7176225.989349998 11140148.67710954 3022249.0386331603 1.0 1.552368709352558 0.4211474169178035 22.77479389277266 -6.773932735880419 1.5594395599639448 1.315229939365292 0.4138224085338895 0.745361633008504 0.23306310920108783 0.26011683512093453 1.248897597855229 0.11776662083024723 0.2793299267167007 1.6829346960991006e-07 6.773932735880419 -0.9014075308314025 down TEYMAFPKPFESSSSIGAEK(ub)PR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TEYMAFPKPFESSSSIGAEKPR 22 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 11113800.0 3867800.0 5909200.0 1336800.0 True False 5297830.183364841 5648112.004888741 1021075.3722602096 1.0 1.0661179783798627 0.19273463605277136 22.336970169629694 -6.888647071347102 1.0303765556231965 1.0484614544556552 0.11958344221498218 0.9800172467153931 0.05612731321574467 0.120246762725068 0.22832651935600462 0.041577909944468874 0.10315991980188549 1.2922690071774314e-07 6.888647071347102 -0.928878012240673 down TFAPEEISAMVLTK ddPTM_RPMI8226_Bortezomib_1h_R1 2 TFAPEEISAMVLTK 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 223109300.0 56558600.0 97550000.0 69000700.0 False True 74148872.31426148 82995920.24692184 61861169.46545133 1.0 1.119314665975827 0.8342833482789624 26.143921415974464 -6.792980680949546 1.4842217062632213 1.066427140571676 0.8309900840914107 0.8108946794301206 0.0508251563401274 0.2309336892399858 1.0048836235628873 0.026948319682871376 0.06296337032018462 1.6107172843418644e-07 6.792980680949546 -0.23543705648026536 TFAPEEISAMVLTK ddPTM_RPMI8226_Bortezomib_2h_R1 2 TFAPEEISAMVLTK 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 229367800.0 69680400.0 60387400.0 99300000.0 False True 67468433.84312259 84500403.73613079 73290351.06385477 1.0 1.2524435342994753 1.0862909791899023 26.00770933689791 -10.445117838828674 3.8045511760070108 0.9986913371906339 1.1693672567542528 0.580787810280984 0.06783149663320219 0.0007602807987308867 0.00011088440092627882 0.06617741785611027 0.021892521393207 3.5882456015691286e-11 10.445117838828674 0.17067591956361894 TFAPEEISAMVLTK ddPTM_RPMI8226_Bortezomib_8h_R1 2 TFAPEEISAMVLTK 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 391045400.0 63285400.0 265755000.0 62005000.0 False True 96008578.58247274 218328943.89670768 49749684.572243005 1.0 2.274056622025291 0.5181795763126241 26.516659983852108 -6.712101035131254 1.7878445819293745 1.7815745157476799 0.5220649243862675 0.47504330675512174 0.5367065941316193 0.3708543511266243 2.3120260722037043 0.23878619652668456 0.6050593680754269 1.9404343985640173e-07 6.712101035131254 -1.2595095913614123 TFAPEEISAMVLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TFAPEEISAMVLTK 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 222574100.0 56558600.0 74683200.0 91332300.0 False True 77469842.85869443 71383449.27968377 69761491.78776284 1.0 0.9214353178679826 0.9004986871473112 26.207131477497356 -13.999999999998304 0.18561756556088624 1.4149755943762297 0.8847977753996648 0.9994924092037347 0.0009649792921237432 12.28263761261018 0.13661473245090278 1.8409537789471786 0.014916584095354993 1.0000000000039061e-14 13.999999999998304 -0.5301778189765649 TFAPEEISAMVLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TFAPEEISAMVLTK 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 165799600.0 69680400.0 56014700.0 40104500.0 False True 57942339.965117924 55712937.69305255 48490165.52774289 1.0 0.9615237790981949 0.8368693007036759 25.788114612332187 -6.949710590943067 0.5620144185884248 1.00161344980309 0.7908015835401735 0.9991783512617392 0.001995797767262734 0.0836022241136483 0.036445296664280195 0.0021342135417632413 0.010366756700259168 1.1227664042206834e-07 6.949710590943067 -0.21081186626291648 TFAPEEISAMVLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TFAPEEISAMVLTK 14 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 210501600.0 63285400.0 84671000.0 62545200.0 False True 81924197.84173365 79958984.41820918 51162615.3679462 1.0 0.9760118075575058 0.6245116426624693 26.287786305944557 -6.920714796275814 0.8194220125733988 1.0075577317133828 0.56688925777358 0.994376848560166 0.012870317736688645 0.0977531052129334 0.1034530164477542 0.011131237318170237 0.033573901559905764 1.2002872800575637e-07 6.920714796275814 -0.4406684739398028 TFCQLILDPIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFCQLILDPIFK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 586610000.0 173910000.0 213970000.0 198730000.0 False True 227997694.14683563 182046510.04852757 178167325.9527679 1.0 0.7984576805907763 0.7814435431878717 27.76444399287599 -13.999999999999954 0.3501460359492142 3.4807507560112323 0.7790974410655133 0.9997549843807595 0.0015537279402014288 20.67537285457259 0.1905031845670517 38.15181774644259 0.0050741226693431915 1.0000000000001063e-14 13.999999999999954 -2.701653314945719 TFCQLILDPIFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFCQLILDPIFK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 1330880000.0 803680000.0 293520000.0 233680000.0 False True 778167618.3121898 410724066.6865789 172472197.75026768 1.0 0.5278092496028307 0.22163887791212905 29.535505706163182 -8.353298229136842 0.2625587190189192 1.20098217174467 3.900673576070371e-21 0.9993064858136878 0.008431432699526484 0.11324219416307975 0.063775611521813 0.10805809593673651 0.10436124103253543 4.433041233472816e-09 8.353298229136842 -1.20098217174467 down TFCQLILDPIFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFCQLILDPIFK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 644525800.0 193150000.0 284274400.0 167101400.0 False True 293022671.1564533 233543412.27397516 134073735.04685445 1.0 0.7970148226151401 0.45755413571828574 28.126437049342538 -6.963387400757166 0.3847335653948316 1.0221115773476421 0.22036260156754117 0.9998759351126557 0.0024925169486928523 0.07851262237673569 0.016816950353385617 0.004398619124639403 0.028620866357202967 1.0879591755227744e-07 6.963387400757166 -0.801748975780101 down TFCQLILDPIFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFCQLILDPIFK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 1347400000.0 173910000.0 290930000.0 882560000.0 False True 238209226.7410359 278075750.6231438 674117504.893755 1.0 1.1673592766641567 2.829938680866495 27.82765405439888 -6.926302689001702 0.776529494586233 0.9709529936364915 3.141211071385543 0.9957605502881692 0.053783357163764735 0.0946036007145339 0.08741878743429174 0.04796154628839737 0.15360641719331633 1.1849425941974502e-07 6.926302689001702 2.1702580777490517 up TFCQLILDPIFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFCQLILDPIFK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 1428850000.0 803680000.0 136710000.0 488460000.0 False True 668295529.0607678 135973516.09518978 590594727.6161354 1.0 0.20346315392276967 0.8837328725603862 29.315910981597458 -10.729628029523417 9.49315975773444 1.001237836306091 0.5435980132432291 0.3750649027444495 0.27771894968814004 0.007290208887619728 0.0002076298745551008 0.269432213241984 0.08963340558903181 1.863682685707922e-11 10.729628029523417 -0.4576398230628619 TFCQLILDPIFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFCQLILDPIFK 12 0 P13639 P13639 EEF2 Elongation factor 2 0 463123000.0 193150000.0 131980000.0 137993000.0 False True 250036482.55570564 124635196.98025593 112879689.92774838 1.0 0.49846804636794734 0.4514528790917538 27.897563371434988 -13.999999999999774 0.3348698624897545 6.6225731069309886 0.4435938406629188 0.9997248586409223 0.0041177999660867055 19.242958373159542 0.18531845613791553 76.39189825886501 0.01479755384419432 1.0000000000005194e-14 13.999999999999774 -6.17897926626807 TFDAQIVIIEHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFDAQIVIIEHK 12 0 P15170-2;P15170-3;P15170 P15170-2 GSPT1 Eukaryotic peptide chain release factor GTP-binding subunit ERF3A 0 43011800.0 13851000.0 19168000.0 9992800.0 False True 17930392.544028394 18101283.94997384 8174212.934786574 1.0 1.0095308234622202 0.45588588842740896 24.095903737198856 -6.90298418036819 0.942207098452467 1.0211719470888585 0.3941166950150785 0.9879934426198501 0.02835496481991445 0.1092419646385476 0.16528937814481418 0.022437716556616687 0.059303758808204085 1.2503045730431137e-07 6.90298418036819 -0.62705525207378 down TFDLYANVRPCVSIEGYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFDLYANVRPCVSIEGYK 18 1 P50213-2;P50213;H0YLI6;H0YMU3;H0YKD0 P50213-2 IDH3A Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0 39253800.0 9042800.0 19066000.0 11145000.0 False True 13718588.717233118 15663523.336662088 8942185.86497296 1.0 1.1417736663382705 0.651829867436721 23.7096287378962 -6.829325214739484 1.3311814172186571 1.0757875973579907 0.6388506266195497 0.904466777813117 0.06362497013835317 0.18164885232711492 0.6298117354057421 0.03753252667634409 0.08636383179667514 1.4814083398518302e-07 6.829325214739484 -0.43693697073844096 TFDLYANVRPCVSIEGYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFDLYANVRPCVSIEGYK 18 1 P50213-2;P50213;H0YLI6;H0YMU3;H0YKD0 P50213-2 IDH3A Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0 21628900.0 9042800.0 6570900.0 6015200.0 False True 11706082.860236788 6205223.638714672 4920495.321164055 1.0 0.530085401991521 0.4203366215592057 23.48075505998865 -13.999999999999954 0.20431946559929764 3.656238664867539 0.35201931984295076 0.9994876221936457 0.0056909108094484705 12.619650715592153 0.14330627568499324 13.421164277960495 0.067696856221225 1.0000000000001063e-14 13.999999999999954 -3.3042193450245883 TFDQLTPEESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFDQLTPEESK 11 0 O43852;O43852-3;O43852-5;O43852-6;O43852-9;O43852-10;O43852-13;O43852-14;O43852-11;O43852-12;O43852-2;O43852-4;O43852-8;O43852-7 O43852;O43852-2 CALU Calumenin 0 15373400.0 2452100.0 7918300.0 5003000.0 False True 3214726.846170175 6736920.50529166 4485337.552164731 1.0 2.0956432156335794 1.395246864444574 21.616264726965262 -10.120328774303722 4.843964916999323 0.9999591393210184 1.7454450400438044 0.6016517360602744 0.28593561303635306 0.0001261864730146955 2.291592418939652e-05 0.2768710818064168 0.09228532227912815 7.580035257464851e-11 10.120328774303722 0.745485900722786 TFDQLTPEESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFDQLTPEESK 11 0 O43852;O43852-3;O43852-5;O43852-6;O43852-9;O43852-10;O43852-13;O43852-14;O43852-11;O43852-12;O43852-2;O43852-4;O43852-8;O43852-7 O43852;O43852-2 CALU Calumenin 0 14055600.0 4992100.0 2922900.0 6140600.0 False True 4833628.51803739 4090029.212722141 4532192.645948715 1.0 0.8461612632124293 0.9376377661287326 22.204675170317824 -10.201689227084241 4.790130436416762 1.0000162111744835 0.8918995146731822 0.6505914935370554 0.0373451259344478 6.466384106661446e-06 1.0776988144896352e-06 0.0361646841089607 0.012053087566999693 6.285079463329656e-11 10.201689227084241 -0.10811669650130129 TFDQLTPEESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFDQLTPEESK 11 0 O43852;O43852-3;O43852-5;O43852-6;O43852-9;O43852-10;O43852-13;O43852-14;O43852-11;O43852-12;O43852-2;O43852-4;O43852-8;O43852-7 O43852;O43852-2 CALU Calumenin 0 30404200.0 5315400.0 20674000.0 4414800.0 False True 8063850.407791947 16984563.17330074 3542212.844924423 1.0 2.1062597040352924 0.4392706543144264 22.94303744502479 -6.727729543178209 1.7311638033553154 1.6673761111976566 0.44057970794131873 0.5489746857565063 0.46512991668787623 0.3404500900738194 1.9977388936938247 0.2129974261886799 0.5299722666080275 1.8718474701977422e-07 6.727729543178209 -1.2267964032563379 TFDQLTPEESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFDQLTPEESK 11 0 O43852;O43852-3;O43852-5;O43852-6;O43852-9;O43852-10;O43852-13;O43852-14;O43852-11;O43852-12;O43852-2;O43852-4;O43852-8;O43852-7 O43852;O43852-2 CALU Calumenin 0 14136000.0 2452100.0 5414200.0 6269700.0 False True 3358707.6355108595 5174982.74163485 4788925.988524722 1.0 1.5407660633872753 1.4258240097746187 21.679474788488154 -10.082986215494685 4.627964998498885 0.999977185510204 1.4832950365207747 0.9593040865182685 0.046924897015006815 32608760.320284616 0.1388437298559327 9577.238607119272 0.016063640357774165 8.260641684348587e-11 10.082986215494685 0.4833178510105707 TFDQLTPEESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFDQLTPEESK 11 0 O43852;O43852-3;O43852-5;O43852-6;O43852-9;O43852-10;O43852-13;O43852-14;O43852-11;O43852-12;O43852-2;O43852-4;O43852-8;O43852-7 O43852;O43852-2 CALU Calumenin 0 9644200.0 4992100.0 2868500.0 1783600.0 False True 4151152.337527704 2853046.821147327 2156542.5135653713 1.0 0.6872903206550381 0.5195045467422523 21.9850804457521 -13.88416149547208 0.07821813339565653 2.6805993336769998 2.5036689190448765e-20 0.9998987215045007 0.0020038134694002653 11.732563351980936 0.07651662908649629 3.4776204906085937 0.4648197133419568 1.3056852695528517e-14 13.88416149547208 -2.6805993336769998 TFDSIVMDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFDSIVMDPK 10 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 18529100.0 3215600.0 7949100.0 7364400.0 False True 4215682.739914698 6763125.265349105 6602402.532313005 1.0 1.604277570822598 1.5661526114857973 22.007334867330076 -10.16386967743804 4.836390824195493 0.9999471015519984 1.5852150911565521 0.996827008821524 0.015564449481437157 8.878896261345292e-06 1.5349963786708187e-06 0.01507157012675341 0.005023404468376485 6.856939577954145e-11 10.16386967743804 0.5852679896045537 TFDSIVMDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFDSIVMDPK 10 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 19267700.0 3215600.0 10191000.0 5861100.0 False True 4404494.218322556 9740727.922869623 4476828.893143567 1.0 2.211542901418398 1.0164229242304603 22.070544928852968 -6.643071134520876 2.034171317518916 1.7904514138345984 1.0214906578639082 0.16626632343752623 0.5179919515030585 0.5256021035596699 4.160635639649388 0.20714175642690266 0.5733334505909584 2.2747248156015698e-07 6.643071134520876 -0.7689607559706901 TFDSIVMDPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFDSIVMDPK 10 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 32803000.0 10984000.0 11638000.0 10181000.0 False True 14219004.527009452 10990335.069375794 8328162.46588165 1.0 0.7729328061257245 0.5857064360632308 23.761317129575435 -6.973335625171283 0.15951072995969812 1.1907662782070265 0.16290748434227786 0.9999980887671324 0.00023411308754864852 0.07523448583978197 0.004921480762082304 0.008706436119020118 0.022507987381999876 1.0633209603161304e-07 6.973335625171283 -1.0278587938647488 TFDTFCPLGPALVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFDTFCPLGPALVTK 15 0 Q96GK7;Q6P2I3 Q96GK7 FAHD2A;FAHD2B Fumarylacetoacetate hydrolase domain-containing protein 2A;Fumarylacetoacetate hydrolase domain-containing protein 2B 0 9199400.0 1798500.0 3714100.0 3686800.0 False True 2357850.916698777 3159970.7574484088 3305325.302282822 1.0 1.3401910761485625 1.4018381225351608 21.16904107112834 -12.394434477318281 0.26726009605849543 1.2189987325879342e-12 1.4242708751631674 0.9994518184718859 0.004137108675806344 6.388340859484224 0.15563526137499362 3.493449282828715 0.02594415262607292 4.03241779566736e-13 12.394434477318281 1.4242708751619484 TFDTFCPLGPALVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFDTFCPLGPALVTK 15 0 Q96GK7;Q6P2I3 Q96GK7 FAHD2A;FAHD2B Fumarylacetoacetate hydrolase domain-containing protein 2A;Fumarylacetoacetate hydrolase domain-containing protein 2B 0 8167600.0 1798500.0 2715100.0 3654000.0 False True 2463454.0526350043 2595137.904364962 2791000.4564922275 1.0 1.0534549656361984 1.13296225415971 21.232251132651232 -6.965397453244821 0.3511656429674134 0.9924188939005076 1.1966859885609182 0.9999210928723035 0.0004852229887337538 0.07782639681594553 0.014385938602782337 0.0010881694177847724 0.006828622604447263 1.0829353904930602e-07 6.965397453244821 0.2042670946604106 TFEGIDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFEGIDPK 8 0 P50395;P50395-2;Q5SX87;Q5SX86 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 3706210.0 1471700.0 699110.0 1535400.0 False True 1424981.6890678501 978268.268810487 1133232.678987338 1.0 0.6865128698253098 0.795261221727446 20.442511950172968 -10.931667542905952 11.033265045792632 1.0456624294859298 0.740887045776439 0.8833081264488643 0.04439632875480967 0.025035467322424426 0.00015505223926027612 0.02158123601822441 0.01432885349167728 1.1703949981291273e-11 10.931667542905952 -0.30477538370949075 TFEGNLTTKPINGAIFIFNPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFEGNLTTKPINGAIFIFNPR 21 1 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 12147600.0 4649300.0 3915700.0 3582600.0 False True 3866098.9489127924 3894605.346894405 4331705.095929179 1.0 1.0073734268983543 1.1204330652600918 21.88244713167388 -6.9201600286702325 0.823549597447103 0.9975197515710292 1.1387315851553297 0.9942250038709316 0.004188525487649291 0.09807771747394223 0.10513055880359001 0.0036118974299674572 0.01083577972099671 1.2018215062727949e-07 6.9201600286702325 0.14121183358430045 TFEINPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFEINPR 7 0 P14625;H0YIV0;Q58FF3 P14625 HSP90B1;HSP90B2P Endoplasmin;Putative endoplasmin-like protein 0 25112100.0 5723900.0 12784000.0 6604200.0 False True 7504088.3303264575 10876677.031641703 5920860.735959695 1.0 1.4494335024929703 0.7890179959678212 22.839245379183584 -6.723500401336343 1.747011283565436 1.2724110228203742 0.7898611150773702 0.5288243255421119 0.1890471021798932 0.348574417591533 2.0810112580842337 0.08586547997108268 0.21464841631658266 1.890164484464147e-07 6.723500401336343 -0.482549907743004 TFEINPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFEINPR 7 0 P14625;H0YIV0;Q58FF3 P14625 HSP90B1;HSP90B2P Endoplasmin;Putative endoplasmin-like protein 0 21067700.0 10829000.0 3632300.0 6606400.0 False True 10485239.322494907 5082696.332194261 4875985.652248245 1.0 0.48474776548875764 0.4650333199154895 23.32185645511063 TFEINPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFEINPR 7 0 P14625;H0YIV0;Q58FF3 P14625 HSP90B1;HSP90B2P Endoplasmin;Putative endoplasmin-like protein 0 80657000.0 17676000.0 52868000.0 10113000.0 False True 26815784.288695164 43433292.34043064 8114161.117314646 1.0 1.6196912934872087 0.3025889912433165 24.676579113092888 -6.778737968772579 1.5405335144545884 1.3514560682618009 0.2925184148974026 0.7629876395031252 0.26192760248559127 0.25253813134489916 1.1836755317687466 0.13391951803700453 0.31636232694364547 1.6644165718861428e-07 6.778737968772579 -1.0589376533643984 TFEINPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFEINPR 7 0 P14625;H0YIV0;Q58FF3 P14625 HSP90B1;HSP90B2P Endoplasmin;Putative endoplasmin-like protein 0 29100100.0 5723900.0 13501000.0 9875200.0 False True 7840180.51258132 12904481.178163359 7542881.1461281 1.0 1.645941845019415 0.962080035532838 22.902455440706476 -6.6590829890277545 1.9761628270676577 1.4161127517785324 0.964944410798063 0.23159146701189115 0.2750910251747603 0.48670182917028837 3.6528130595753554 0.11250376336998365 0.3049167133697744 2.1923859538270035e-07 6.6590829890277545 -0.4511683409804693 TFEINPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFEINPR 7 0 P14625;H0YIV0;Q58FF3 P14625 HSP90B1;HSP90B2P Endoplasmin;Putative endoplasmin-like protein 0 20116300.0 10829000.0 7611400.0 1675900.0 False True 9004793.306041034 7570395.877455399 2026322.941513906 1.0 0.8407073455396981 0.22502714639263396 23.102261730544907 -6.945663783320527 0.6045830999988335 1.0068708093832144 0.027097988233315815 0.9988155179453918 0.011500854485363919 0.08527519429355825 0.043539422615431866 0.011751100585610205 0.051818861856521355 1.1332773702411731e-07 6.945663783320527 -0.9797728211498986 down TFEINPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFEINPR 7 0 P14625;H0YIV0;Q58FF3 P14625 HSP90B1;HSP90B2P Endoplasmin;Putative endoplasmin-like protein 0 47878000.0 17676000.0 13998000.0 16204000.0 False True 22881930.446050502 13218998.994769078 13255038.267080454 1.0 0.577704710095853 0.5792797202286889 24.447705435185338 -9.998058652937845 5.164447118234636 1.0000028205413662 0.5784922151599023 0.9999895275753623 0.000642995202451308 2.0882042988593386e-08 4.051709448016086e-09 0.0006225815934937177 0.0002075258080447903 1.0044801226813639e-10 9.998058652937845 -0.4215106053814639 TFESLVDFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFESLVDFSK 10 0 A0A0D9SFP2;E9PF18;Q16836;Q16836-3;Q16836-2;A0A1W2PQV5;A0A1W2PNM1;A0A0A0MSE2;A0A1W2PQC2;A0A1W2PRT2;A0A1W2PQ78 A0A0D9SFP2 HADH Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 0 18022800.0 7035100.0 4568200.0 6419500.0 False True 9223084.228005301 3886642.3667041343 5755271.720192184 1.0 0.42140375937396246 0.6240072819368462 23.136817842363296 -10.060040530576423 5.042072964007238 1.0000086984562417 0.5227055206531059 0.8809489646277674 0.08271254173624944 8.087813002583016e-06 1.507728866322798e-06 0.08008753283177082 0.02669535805443622 8.70882310983753e-11 10.060040530576423 -0.4773031778031358 TFESLVDFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFESLVDFSK 10 0 A0A0D9SFP2;E9PF18;Q16836;Q16836-3;Q16836-2;A0A1W2PQV5;A0A1W2PNM1;A0A0A0MSE2;A0A1W2PQC2;A0A1W2PRT2;A0A1W2PQ78 A0A0D9SFP2 HADH Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 0 17656600.0 6806300.0 3332700.0 7517600.0 False True 6590237.732080259 4663464.489800901 5548515.036834186 1.0 0.7076322098518353 0.8419294208196575 22.65189907836737 -10.192596887338409 5.087485975110729 1.0000175773459825 0.7747808153355613 0.7894676531096141 0.054826606792321965 1.0931579654740335e-05 1.73488289643678e-06 0.053089774383324864 0.017695211252884775 6.41805024391982e-11 10.192596887338409 -0.2252367620104212 TFESLVDFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFESLVDFSK 10 0 A0A0D9SFP2;E9PF18;Q16836;Q16836-3;Q16836-2;A0A1W2PQV5;A0A1W2PNM1;A0A0A0MSE2;A0A1W2PQC2;A0A1W2PRT2;A0A1W2PQ78 A0A0D9SFP2 HADH Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 0 20594400.0 7035100.0 6525300.0 7034000.0 False True 9636166.586428959 6236990.66971849 5372714.069777325 1.0 0.6472481161235133 0.557557200945857 23.200027903886188 -13.999999999999998 0.1922857889615406 2.906134753861159 0.4946712075933944 0.9994883125399807 0.004319888280933083 12.3888783001864 0.1390601518362573 8.854916195939714 0.06057898623644818 1.0000000000000041e-14 13.999999999999998 -2.4114635462677647 TFESLVDFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFESLVDFSK 10 0 A0A0D9SFP2;E9PF18;Q16836;Q16836-3;Q16836-2;A0A1W2PQV5;A0A1W2PNM1;A0A0A0MSE2;A0A1W2PQC2;A0A1W2PRT2;A0A1W2PQ78 A0A0D9SFP2 HADH Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 0 12702500.0 6806300.0 3718300.0 2177900.0 False True 5659740.020214897 3698268.779875237 2633288.820528154 1.0 0.6534343921569062 0.4652667456672629 22.432304353801648 -11.45744289586527 0.09987183912906734 2.1104593920852768 4.0585316825040305e-15 0.9998777657317106 0.002448595064935632 4.2955517705669 0.06621752685027471 1.375890014984667 0.32197395116701655 3.4878444178532863e-12 11.45744289586527 -2.110459392085273 TFESLVDFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFESLVDFSK 10 0 A0A0D9SFP2;E9PF18;Q16836;Q16836-3;Q16836-2;A0A1W2PQV5;A0A1W2PNM1;A0A0A0MSE2;A0A1W2PQC2;A0A1W2PRT2;A0A1W2PQ78 A0A0D9SFP2 HADH Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 0 20823600.0 5972600.0 7528300.0 7322700.0 False True 7731648.4375470355 7109343.487092443 5990043.737246987 1.0 0.9195119959887846 0.7747434179957884 22.882344608200462 -6.9620659871261985 0.40526887681625995 1.0075100753242352 0.6814140084755546 0.9998393070494721 0.0011814378587371667 0.07897123123106752 0.0184641049427448 0.0018625563254875625 0.012106267099326344 1.0912745145398305e-07 6.9620659871261985 -0.32609606684868064 TFFPEYTHQLFGDDETAFGYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFFPEYTHQLFGDDETAFGYK 21 0 O14929 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 0 15449000.0 6483700.0 2296700.0 6668600.0 False True 6277878.492497943 3213784.2871322753 4921893.606288242 1.0 0.5119220276360467 0.7840058727116013 22.581845675344063 -10.137297697322131 5.415293487122225 1.0000074955063798 0.647963950173716 0.6906006082565437 0.11107776461531295 1.0052093635548443e-05 1.6017220744723594e-06 0.10755287234930107 0.035850194374032425 7.289576578604052e-11 10.137297697322131 -0.3520435453326638 TFFPEYTHQLFGDDETAFGYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFFPEYTHQLFGDDETAFGYK 21 0 O14929 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 0 31679000.0 5437300.0 20816000.0 5425700.0 False True 8248781.619875668 17101222.163849656 4353308.0168312155 1.0 2.0731815863137637 0.527751638659193 22.97574961222559 -6.719935301197505 1.7593204707047647 1.6529656407588749 0.5301394453091526 0.5122293516125429 0.4516052006092938 0.3554871329448007 2.1502799075328585 0.20380931599818847 0.5117205448359383 1.905744604162847e-07 6.719935301197505 -1.1228261954497223 TFFPEYTHQLFGDDETAFGYK(ub)GLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFFPEYTHQLFGDDETAFGYKGLK 24 1 O14929 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 14235500.0 5987900.0 4300900.0 3946700.0 True False 5797817.39211075 6018271.798897202 2912940.871537924 1.0 1.0380236892397525 0.5024202513693589 22.467078464357673 -6.889850513436602 1.0232266853044243 1.0288816837685744 0.45648121092059224 0.98080385787309 0.033808709100246186 0.11926612492912536 0.22253715103243854 0.0251798102216861 0.06274238939004038 1.2886930506390632e-07 6.889850513436602 -0.5724004728479821 TFFPEYTHQLFGDDETAFGYK(ub)GLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFFPEYTHQLFGDDETAFGYKGLK 24 1 O14929 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 24131300.0 7312800.0 7832600.0 8985900.0 True False 9466563.75683855 7396708.924591246 7350558.403120104 1.0 0.7813509859105885 0.7764758778294959 23.174409409948613 TFFSFPAVVAPFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFFSFPAVVAPFK 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 234372000.0 83145000.0 82045000.0 69182000.0 False True 109003900.17732534 69804205.80890511 62023710.280603774 1.0 0.6403826440645614 0.5690045051571995 26.699804514888452 -13.999999999999998 0.22733615455734887 3.242528430060839 0.5334083657805794 0.9995062732673312 0.004190988291629075 13.209681328410177 0.1509882381069742 13.351544600570026 0.037675442794429116 1.0000000000000041e-14 13.999999999999998 -2.7091200642802598 TFFSFPAVVAPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFFSFPAVVAPFK 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 271760000.0 0.0 131710000.0 140050000.0 False True 0.0 184302489.85857654 103366703.5900591 0.0 TFFSFPAVVAPFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFFSFPAVVAPFK 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 110427000.0 29251000.0 46711000.0 34465000.0 False True 44375905.53454529 38375057.09529125 27652977.64345387 1.0 0.8647723721472554 0.6231529770570399 25.403273223645648 -6.962188709572215 0.403409838375155 1.0127927671066363 0.4662614152668942 0.9998429459088315 0.0019534672275841477 0.07892841460177978 0.018309609907046148 0.0031083194447170614 0.020218597489994692 1.090966186980923e-07 6.962188709572215 -0.5465313518397421 TFFSFPAVVAPFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFFSFPAVVAPFK 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 311014000.0 83145000.0 61689000.0 166180000.0 False True 113885953.4091394 58963376.00175692 126931706.58453143 1.0 0.5177405486515871 1.114551029208358 26.763014576411344 -6.691703837547423 1.8605213662366897 0.6981370124672821 1.1125233819023481 0.37836901631702424 0.20389173370822547 0.41300048229847264 2.773126091340431 0.0876297111126558 0.22769154550221968 2.033743427621005e-07 6.691703837547423 0.414386369435066 TFFSFPAVVAPFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFFSFPAVVAPFK 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 185856000.0 0.0 82306000.0 103550000.0 False True 0.0 81862601.24153818 125201826.23889536 0.0 TFFSFPAVVAPFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFFSFPAVVAPFK 13 0 P41250 P41250 GARS Glycine--tRNA ligase 0 94877000.0 29251000.0 33417000.0 32209000.0 False True 37865996.1234116 31557314.57409618 26347292.492248487 1.0 0.833394544045418 0.6958034962655746 25.174399545738098 -6.973318766609951 0.16015966486661412 1.1389501438950491 0.3865966568441796 0.9999980529871371 0.00017345229379952962 0.07523972075242032 0.004944748532537437 0.006358654951901453 0.016501301071743288 1.0633622373995513e-07 6.973318766609951 -0.7523534870508695 TFGETHPFTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFGETHPFTK 10 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 3949000.0 1024300.0 1711800.0 1212900.0 False True 1342867.219335309 1456406.1125441391 1087400.7429583475 1.0 1.084549605183623 0.8097604344654329 20.356885229654054 -6.8240948367661325 1.3540410749573502 1.0453929678282232 0.8032168603793018 0.8935478650695413 0.03749327342495115 0.18821358616578585 0.6769041133354956 0.02175280105190259 0.05009103370451223 1.4993573854926966e-07 6.8240948367661325 -0.24217610744892137 TFGETHPFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFGETHPFTK 10 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 12718700.0 2809200.0 7374200.0 2535300.0 False True 4261761.780029565 6058216.39511243 2034196.8437385373 1.0 1.4215286324779988 0.47731359675491425 22.023018522281692 -6.785344606978004 1.514954502314493 1.237023069910375 0.4685284030613047 0.785880102650347 0.17871170639917475 0.24235425400789595 1.0988701566959904 0.09288082017559977 0.21821016993547546 1.6392885030605007e-07 6.785344606978004 -0.7684946668490703 down TFGETHPFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFGETHPFTK 10 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 3478100.0 1024300.0 1127300.0 1326500.0 False True 1403011.3906666834 1077492.1585174096 1013208.0201250522 1.0 0.7679853247701763 0.7221666387495227 20.420095291176946 -13.999999999999998 0.22805241827973174 2.451562147144227 0.6994723308972977 0.9995071948908323 0.0026998492608277876 13.231294489545 0.15122000701522065 8.687158838913064 0.024075384715779396 1.0000000000000041e-14 13.999999999999998 -1.7520898162469294 TFGETHPFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFGETHPFTK 10 0 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 0 6969400.0 2809200.0 2310900.0 1849300.0 False True 3636564.777610613 2182296.383555637 1512746.375420382 1.0 0.6000983117340493 0.4159822436641221 21.79414484437414 -13.999999999997597 0.10408926102335482 2.9534384574493466 0.04755850421820949 0.9997730960233306 0.0036722671942268545 12.050638711370995 0.09688330692767616 5.007386287300778 0.3279050318325213 1.000000000005534e-14 13.999999999997597 -2.9058799532311372 TFGK(ub)QQWQQLYDTLNAWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFGKQQWQQLYDTLNAWK 18 1 Q7L2H7;Q7L2H7-2;H0YCQ8 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 1 230674200.0 19070000.0 148873200.0 62731000.0 True False 28930584.203746125 122305614.30837944 50332190.35402593 1.0 4.227554253555049 1.7397571372758032 24.786092120536 -6.580365073977119 2.265270140849158 3.197375114669362 1.7459243260994548 0.0 1.402011648144946 0.6982670068871367 6.739927834519416 0.5195482946645972 1.5672060398907623 2.6280578811221617e-07 6.580365073977119 -1.4514507885699073 TFGK(ub)QQWQQLYDTLNAWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFGKQQWQQLYDTLNAWK 18 1 Q7L2H7;Q7L2H7-2;H0YCQ8 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 1 9886500.0 3785700.0 4522700.0 1578100.0 True False 3147977.284945936 4498335.317414337 1908073.413690015 1.0 1.4289605388596673 0.6061268049215878 21.585993700063447 -6.765042074470379 1.5935211325318668 1.247595756142573 0.6023501743576086 0.7112069296287966 0.18057657997088206 0.2745223230036694 1.374934749075325 0.08936530574070987 0.21370099760956507 1.717741964171744e-07 6.765042074470379 -0.6452455817849644 TFGK(ub)QQWQQLYDTLNAWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFGKQQWQQLYDTLNAWK 18 1 Q7L2H7;Q7L2H7-2;H0YCQ8 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 1 170551800.0 19070000.0 121741800.0 29740000.0 True False 24686490.925898556 114966761.81035687 24327625.158169147 1.0 4.657071843683763 0.9854630709238257 24.55721844262845 -6.6470977167028105 2.019018012414949 3.37852119406674 1.000907523950297 0.18232916000420318 1.5620011927718116 0.515671634310923 4.025897204879767 0.6281740416986222 1.7297899045130898 2.2537320630797644e-07 6.6470977167028105 -2.3776136701164434 TFGQK(ub)PVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFGQKPVK 8 1 G5E975;Q12824-2;Q12824;A0A0G2JSE9;C9JTA6;A0A2R8Y5N5;A0A0G2JRV3;B5MCL5;A0A2R8YDN6 G5E975 SMARCB1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 1 2482100.0 798000.0 877800.0 806300.0 True False 1046185.7278429935 746835.6616376011 722871.81057574 1.0 0.7138652743594708 0.6909593500822686 19.996707563215306 -13.999999999999954 0.3579142726193972 4.695571037423035 0.6881184632284553 0.9997694921797219 0.002134581328289455 21.47299167107948 0.19317608589707155 60.5567712334585 0.006655032473480324 1.0000000000001063e-14 13.999999999999954 -4.00745257419458 TFGQK(ub)PVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFGQKPVK 8 1 G5E975;Q12824-2;Q12824;A0A0G2JSE9;C9JTA6;A0A2R8Y5N5;A0A0G2JRV3;B5MCL5;A0A2R8YDN6 G5E975 SMARCB1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 1 2931960.0 1100800.0 1059400.0 771760.0 True False 1065855.706547456 1482423.9446980176 569612.9036962807 1.0 1.3908298614827692 0.5344184022257419 20.023580711418727 -6.782631918360619 1.5256678731847402 1.2205414334536784 0.5270717526055145 0.7765763404550021 0.1654711105328133 0.24650607594248747 1.133482994785185 0.08541065687248256 0.20109013711431986 1.6495598660418883e-07 6.782631918360619 -0.6934696808481638 TFGQK(ub)PVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFGQKPVK 8 1 G5E975;Q12824-2;Q12824;A0A0G2JSE9;C9JTA6;A0A2R8Y5N5;A0A0G2JRV3;B5MCL5;A0A2R8YDN6 G5E975 SMARCB1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 1 2792270.0 798000.0 970370.0 1023900.0 True False 1093042.1651391343 927495.844815524 782075.9078824278 1.0 0.8485453483832092 0.7155038779157039 20.059917624738198 -6.972649193377115 0.1842393201917825 1.0972462119784219 0.46319001764652584 0.9999963479233588 0.00022203778899380935 0.0754521150895039 0.005838345813605329 0.004936070952432185 0.014742674270015736 1.0650029398831263e-07 6.972649193377115 -0.6340561943318961 TFGQK(ub)PVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFGQKPVK 8 1 G5E975;Q12824-2;Q12824;A0A0G2JSE9;C9JTA6;A0A2R8Y5N5;A0A0G2JRV3;B5MCL5;A0A2R8YDN6 G5E975 SMARCB1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 1 3006510.0 1100800.0 1309400.0 596310.0 True False 915363.9737085582 1302346.0023044492 720995.6639740777 1.0 1.422763009809147 0.7876600835108185 19.803985986853004 -6.727276962807791 1.7333435407388003 1.2551844048344738 0.7882333822753582 0.5465554720919943 0.1777601228350352 0.3413459185514564 2.0079313522381246 0.08131546093153502 0.20238961636226493 1.8737991482079857e-07 6.727276962807791 -0.4669510225591156 TFHIFYYLLSGAGEHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFHIFYYLLSGAGEHLK 17 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 249525300.0 63672300.0 66634800.0 119218200.0 False True 61651057.68895496 93242423.13589135 87991376.95066318 1.0 1.5124221161998996 1.4272484568651156 25.87762231000787 -10.690633078816875 6.591862935333687 0.9957081828216242 1.469835286532474 0.9759449671157636 0.03477200081597704 0.0022038853919753606 0.00010343179372617576 0.03383166299251011 0.011222615006215821 2.038763835062835e-11 10.690633078816875 0.47412710371084976 TFHIFYYLLSGAGEHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFHIFYYLLSGAGEHLK 17 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 336478000.0 73486000.0 99302800.0 163689200.0 False True 111483634.54622382 81581439.4836823 131335957.87247483 1.0 0.7317795102011736 1.1780738796959456 26.732256701604264 -6.743934006784721 1.6720708663980999 0.8411454197774081 1.1785792250159977 0.6225881525909789 0.11269037384745963 0.31073193331066995 1.7071835845100132 0.05328297019751633 0.13020253096160195 1.803291739226279e-07 6.743934006784721 0.33743380523858957 TFHIFYYLLSGAGEHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFHIFYYLLSGAGEHLK 17 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 226819000.0 63672300.0 97769000.0 65377700.0 False True 52946338.61115866 97242298.99137293 79047874.79766902 1.0 1.8366198974687686 1.4929809477139058 25.658027585442145 -10.052290063836557 4.973705498407899 0.9999894518632925 1.6648004225906934 0.8330602146920113 0.14029001379737227 97192679.93088263 11.72119001026888 14308.366071961182 0.04802500321489313 8.865636813251084e-11 10.052290063836557 0.6648109707274009 TFHIFYYLLSGAGEHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFHIFYYLLSGAGEHLK 17 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 242369170.0 73486000.0 99985970.0 68897200.0 False True 95129075.62562044 94421662.87476857 56358616.54497014 1.0 0.9925636536863253 0.5924436474792305 26.503383023696713 -6.910926835180647 0.8894025383687304 1.0120283062702515 0.539697021160356 0.9912665833783461 0.017792968131876204 0.1038082358757982 0.13546750881545327 0.014634428841844776 0.04066166410783233 1.2276460330830392e-07 6.910926835180647 -0.4723312851098955 TFHTIGFCPYGPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFHTIGFCPYGPR 13 0 P47974;G3V2D5;G3V2P5;Q07352 P47974 ZFP36L2;ZFP36L1 Zinc finger protein 36, C3H1 type-like 2;Zinc finger protein 36, C3H1 type-like 1 0 13355500.0 4094200.0 5113800.0 4147500.0 False True 5367535.848289203 4350840.97343627 3718356.485629274 1.0 0.8105844276425309 0.6927492597584471 22.355828490802047 -11.88402105603601 0.05293227758285724 2.1136323610709233 5.641532524376853e-12 0.9999842336506692 0.0005025134469914793 5.507973788749172 0.039984086739630956 1.220970240857341 0.5073175950482565 1.3061075621728442e-12 11.88402105603601 -2.1136323610652816 TFHTIGFCPYGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFHTIGFCPYGPR 13 0 P47974;G3V2D5;G3V2P5;Q07352 P47974 ZFP36L2;ZFP36L1 Zinc finger protein 36, C3H1 type-like 2;Zinc finger protein 36, C3H1 type-like 1 0 8059000.0 4258100.0 1510000.0 2290900.0 False True 4122928.9462660938 2112950.8745459723 1690844.564473161 1.0 0.5124878216636631 0.4101076168204316 21.975238167646236 -13.999999999999998 0.21935151642248876 3.933522191770474 0.35500277378343026 0.9994972507644916 0.005770615308231261 12.982050476771233 0.14837527077623203 16.490512130024587 0.056902962512422176 1.0000000000000041e-14 13.999999999999998 -3.578519417987044 TFHTIGFCPYGPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFHTIGFCPYGPR 13 0 P47974;G3V2D5;G3V2P5;Q07352 P47974 ZFP36L2;ZFP36L1 Zinc finger protein 36, C3H1 type-like 2;Zinc finger protein 36, C3H1 type-like 1 0 14652000.0 3525100.0 5340700.0 5786200.0 False True 5347834.4193301285 4387610.357920446 4642555.033818449 1.0 0.8204461869763798 0.8681186943704919 22.35052336644777 -9.9346757796821 5.126793206479115 1.0000005378245378 0.8442824406712344 0.9343221736418285 0.01946221965343835 1.1964531350890198e-07 2.4866300415431933e-08 0.018844278291359068 0.006281404382065386 1.1623160110809456e-10 9.9346757796821 -0.15571809715330343 TFHTIGFCPYGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFHTIGFCPYGPR 13 0 P47974;G3V2D5;G3V2P5;Q07352 P47974 ZFP36L2;ZFP36L1 Zinc finger protein 36, C3H1 type-like 2;Zinc finger protein 36, C3H1 type-like 1 0 14346100.0 4094200.0 3147200.0 7104700.0 False True 5607936.381594791 3008146.2976013417 5426716.1858895235 1.0 0.5364087772953448 0.967685047872506 22.41903855232494 -10.527024755734102 9.167217631577019 1.0000114420152377 0.7520469125839253 0.3059045064671926 0.1760678001807565 4.117583416622271e-05 2.124501405382501e-06 0.17048477211916263 0.05682563815862041 2.97149664511093e-11 10.527024755734102 -0.24796452943131242 TFHTIGFCPYGPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFHTIGFCPYGPR 13 0 P47974;G3V2D5;G3V2P5;Q07352 P47974 ZFP36L2;ZFP36L1 Zinc finger protein 36, C3H1 type-like 2;Zinc finger protein 36, C3H1 type-like 1 0 7808260.0 4258100.0 962960.0 2587200.0 False True 3540798.8158143223 957772.3433474057 3128171.5581387742 1.0 0.2704961205560996 0.8834649244027577 21.755643443080512 -10.476560193804804 8.60733961461232 1.0000132110149744 0.5769805224797819 0.3883841250626491 0.25024346627807714 6.344296742516856e-05 3.858094348067788e-06 0.24230474545275207 0.0807657314493509 3.337642417829391e-11 10.476560193804804 -0.4230326885351925 TFHTIGFCPYGPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFHTIGFCPYGPR 13 0 P47974;G3V2D5;G3V2P5;Q07352 P47974 ZFP36L2;ZFP36L1 Zinc finger protein 36, C3H1 type-like 2;Zinc finger protein 36, C3H1 type-like 1 0 16091200.0 3525100.0 6028600.0 6537500.0 False True 4563311.440109338 5693103.110434688 5347742.080414618 1.0 1.2475815392293892 1.1718994310601965 22.12164968854022 -10.068049557108674 4.271512116383681 0.999978795638526 1.2097404851848605 0.9110351741010484 0.03089709140712675 10719505.027251301 0.09929719308832796 2311.076497173277 0.010576896200452896 8.549691472507683e-11 10.068049557108674 0.20976168954633456 TFIAIK(ub)PDGVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFIAIKPDGVQR 12 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 379518000.0 94999000.0 122390000.0 162129000.0 True False 124544608.97162476 104129889.07248338 145353446.33118472 1.0 0.8360850777267083 1.1670793905202341 26.89208733364248 -6.772097746682275 1.5668739370964904 0.9062328185411962 1.1690702509675397 0.738353239867876 0.06912087098014674 0.26305522979097357 1.2749141634962609 0.03476879942254552 0.08259071214207143 1.6900605068250714e-07 6.772097746682275 0.2628374324263435 TFIAIK(ub)PDGVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFIAIKPDGVQR 12 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 573245000.0 153530000.0 194950000.0 224765000.0 True False 148656274.18807307 272794551.6508196 165892303.69453496 1.0 1.8350692101006951 1.115945523326218 27.147405114029603 -10.194327526877613 4.338982125582048 0.9998523502213145 1.4755073667316385 0.3682760033549547 0.29358101582615476 206266327.34864897 88.18868993470467 312886.83075855626 0.10050059050430671 6.392525558954032e-11 10.194327526877613 0.47565501651032405 TFIAIK(ub)PDGVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFIAIKPDGVQR 12 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 1187937000.0 303720000.0 384796000.0 499421000.0 True False 460765444.90622926 316126147.37512934 400710220.4459996 1.0 0.6860890955906306 0.8696620479592355 28.779457285055088 -10.22764286823247 5.3651865957877405 1.0000159498126224 0.7778755726759342 0.6612642421428007 0.07494334397998847 1.4299086551834206e-05 2.058488328357282e-06 0.07256878837722615 0.02418786026195113 5.920482909238442e-11 10.22764286823247 -0.22214037713668822 TFIAIK(ub)PDGVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFIAIKPDGVQR 12 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 356287000.0 94999000.0 114300000.0 146988000.0 True False 130122697.55144441 109249848.06044549 112272461.7128843 1.0 0.8395910176797036 0.8628199678115115 26.95529739516537 -10.05653010758698 7.051876359989947 1.0000000330638896 0.851205492767 0.9820493531692955 0.009483179180581091 4.925159657483012e-09 6.596812329948621e-10 0.009182050811218341 0.0030606829196242586 8.779502208410354e-11 10.05653010758698 -0.14879454029688965 TFIAIK(ub)PDGVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFIAIKPDGVQR 12 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 487384000.0 153530000.0 191290000.0 142564000.0 True False 127666997.53222644 190259482.8019081 172373473.25854057 1.0 1.490279292844509 1.3501803644675598 26.92781038946388 -9.966185643991402 4.874095263882989 0.9999964328145865 1.4202298286075268 0.9230542938141507 0.05719514805070436 39285288.75871539 3.304504452748078 1694.0269643010313 0.019579420472709125 1.0809717791527162e-10 9.966185643991402 0.4202333957929403 TFIAIK(ub)PDGVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFIAIKPDGVQR 12 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 1 1078295000.0 303720000.0 432603000.0 341972000.0 True False 393171527.21625197 408528262.76140016 279736604.9290322 1.0 1.0390586155968047 0.7114874439398854 28.550583607147537 -6.877137618814287 1.095693735454463 1.0233996274446642 0.6895151527478027 0.9712998034237539 0.024748484639315026 0.13019314261721074 0.2878960141083472 0.017442409795838214 0.041888172217390225 1.3269739008974973e-07 6.877137618814287 -0.33388447469686144 TFIAIKPDGVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFIAIKPDGVQR 12 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 565560000.0 127390000.0 209290000.0 228880000.0 False True 167009523.6465149 178064747.80603036 205197693.17198974 1.0 1.0661951720963798 1.228658633901036 27.315355133210442 -6.955855689824159 0.490364413477778 0.9964563250611753 1.3052909303801365 0.9995842811737055 0.0019587325826988153 0.08121613040288701 0.02686459460978161 0.002340969413561739 0.013399504807165966 1.1069915611773258e-07 6.955855689824159 0.30883460531896123 TFIAIKPDGVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFIAIKPDGVQR 12 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 440520000.0 185910000.0 104350000.0 150260000.0 False True 180008388.81198883 146017499.17806134 110902398.29662465 1.0 0.8111705245613329 0.6160957221413582 27.423488900184118 -6.9707170729656625 0.24044192167079065 1.0696630859467768 0.35195781966754014 0.9999874468896605 0.000555288502558267 0.07607070499638613 0.008193044202089703 0.004648474381941414 0.019002867350209254 1.0697515564378622e-07 6.9707170729656625 -0.7177052662792367 TFIAIKPDGVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFIAIKPDGVQR 12 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 1087120000.0 224970000.0 667340000.0 194810000.0 False True 341295937.5100561 548247963.0487819 156305718.11174378 1.0 1.6063711951819764 0.45797708361863615 28.346448001051126 -6.763237572301325 1.6001169329216707 1.3507996033198482 0.4530758517274197 0.7040661996313838 0.2551759613417572 0.2775335180583213 1.4011572226830291 0.1257785558051036 0.30132752909816196 1.724894064304349e-07 6.763237572301325 -0.8977237515924285 TFIAIKPDGVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFIAIKPDGVQR 12 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 658950000.0 127390000.0 204910000.0 326650000.0 False True 174489525.5853061 195856398.65324458 249501997.5679218 1.0 1.1224536143144732 1.429896704292103 27.378565194733333 -6.955370281437661 0.49640234598381094 0.9936461470349549 1.5718835512859286 0.9995580950398308 0.0038015260340939546 0.08139834690061835 0.027572748077111797 0.004488961347010786 0.02535873372716253 1.1082295308371731e-07 6.955370281437661 0.5782374042509737 TFIAIKPDGVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFIAIKPDGVQR 12 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 352130000.0 185910000.0 82643000.0 83577000.0 False True 154592402.2094457 82197785.75564884 101052564.28361343 1.0 0.5317065042063659 0.6536709620871591 27.203894175618395 -10.182055695763221 7.9169360263196005 1.0000001362428426 0.5926887331467766 0.9369899350201278 0.04979178142718567 1.1969667740323335e-07 1.2431602949604717e-08 0.04821070086576963 0.01607022835379082 6.575735019376262e-11 10.182055695763221 -0.40731140309606595 TFIAIKPDGVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFIAIKPDGVQR 12 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;E5RHP0;F6XY72;C9K028;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 610310000.0 224970000.0 203050000.0 182290000.0 False True 291228099.8216781 191750089.0047047 149115090.45335105 1.0 0.6584189132920732 0.5120216440125651 28.117574323143575 -13.999999999999998 0.11563961954130739 2.6347534195375992 0.2640198923374231 0.9997145774171757 0.003454224498479374 11.982550352646749 0.10406755701679694 4.529916355332123 0.2200770071290476 1.0000000000000041e-14 13.999999999999998 -2.370733527200176 TFIGK(ub)IPIMLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFIGKIPIMLR 11 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 6508600.0 1291900.0 1898200.0 3318500.0 True False 1250889.3416503065 2656161.158982227 2449285.297133963 1.0 2.123418171808816 1.9580351479393092 20.254522738273486 -10.120493974787873 5.700506997691031 0.9999899144820111 2.0407266598741605 0.9814124845776725 0.06751733676681744 8.654472217223773e-06 1.3353324314311986e-06 0.06537401321756162 0.021791126739796277 7.577152450036029e-11 10.120493974787873 1.0407367453921492 TFIGPGGNMPGYLRPETAQGIFLNFK ddPTM_RPMI8226_Bortezomib_2h_R1 2 TFIGPGGNMPGYLRPETAQGIFLNFK 26 1 P41250 P41250 GARS Glycine--tRNA ligase 0 209127000.0 101619700.0 39535000.0 67972300.0 False True 98393838.24731152 55321531.67230143 50168315.50470955 1.0 0.5622458952485575 0.509872532654049 26.55206463619488 -13.999999999999998 0.29954789268265253 4.982696315040248 0.49692558825442623 0.9996488218549253 0.004117989176980936 16.55887349047095 0.17380224441454412 40.864308324408164 0.018964032932522003 1.0000000000000041e-14 13.999999999999998 -4.485770726785821 TFIGPGGNMPGYLRPETAQGIFLNFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFIGPGGNMPGYLRPETAQGIFLNFK 26 1 P41250 P41250 GARS Glycine--tRNA ligase 0 74869000.0 10099000.0 40319000.0 24451000.0 False True 15320921.33579615 33123759.43621516 19618249.132746 1.0 2.1619952684453807 1.2804875570315393 23.86899972169744 -10.121676755294269 4.447816757892896 0.9999294637699759 1.7212414125022386 0.47162113080378165 0.35987401648831213 125520525.13150986 20.44028552006298 114954.66799086769 0.12319444788925232 7.556544508381103e-11 10.121676755294269 0.7213119487322627 TFIGPGGNMPGYLRPETAQGIFLNFK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TFIGPGGNMPGYLRPETAQGIFLNFK 26 1 P41250 P41250 GARS Glycine--tRNA ligase 0 187162400.0 101619700.0 38945500.0 46597200.0 False True 84501283.06601705 38735692.86142348 56340459.07889006 1.0 0.45840360590928575 0.6667408710809019 26.332469911629158 -10.168342475664573 5.345147107314978 1.0000156882510955 0.5625722384949643 0.85460544164517 0.0850533323466877 1.590169824087627e-05 2.4740358154488054e-06 0.08235548498268827 0.02745084497644754 6.786682377796968e-11 10.168342475664573 -0.43744344975613125 TFIGPGGNMPGYLRPETAQGIFLNFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFIGPGGNMPGYLRPETAQGIFLNFK 26 1 P41250 P41250 GARS Glycine--tRNA ligase 0 78618000.0 10099000.0 50927000.0 17592000.0 False True 13073354.581051383 48092867.68156914 14390436.509163126 1.0 3.678693741794114 1.1007455217363056 23.640126043789888 -6.637173674544047 2.0542107864051435 2.755398470558775 1.1112921285142037 0.14403902416849224 1.1469336057536093 0.5405176449853792 4.355497734976097 0.4551788120930289 1.2704088037530619 2.3058249039826512e-07 6.637173674544047 -1.6441063420445714 TFIIGISGVTNSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFIIGISGVTNSGK 14 0 B3KN26;Q9NWW6-2;Q9NWW6 B3KN26 NMRK1 Nicotinamide riboside kinase 1 0 5879700.0 1810800.0 1805000.0 2263900.0 False True 2373976.3358121472 1535701.0358348938 2029653.3448622325 1.0 0.6468897826268871 0.8549593836485652 21.178874123353438 -10.23851088261833 5.538864467548941 1.00001508501864 0.7509245831377146 0.6564351989774566 0.08494405891463871 1.5824386034349743e-05 2.17554615105005e-06 0.08225170924899078 0.027415577127965548 5.774164035431116e-11 10.23851088261833 -0.2490905018809254 TFIIGISGVTNSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFIIGISGVTNSGK 14 0 B3KN26;Q9NWW6-2;Q9NWW6 B3KN26 NMRK1 Nicotinamide riboside kinase 1 0 7144600.0 1810800.0 2311400.0 3022400.0 False True 2480301.6950300066 2209274.70522234 2308571.3682819153 1.0 0.8907282165106177 0.930762323352759 21.24208418487633 -10.264852322382879 7.114554128451851 1.000000525270852 0.910745270240981 0.8688931201211902 0.016343855678551813 1.361593925459117e-07 1.408661436776283e-08 0.015824963357840297 0.005274956737987387 5.434350898979989e-11 10.264852322382879 -0.08925525502987097 TFIVGAQMNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFIVGAQMNVK 11 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 0 5981120.0 2725200.0 685620.0 2570300.0 False True 2638690.0176990633 959391.6414610656 1897061.3226528305 1.0 0.36358633830648085 0.7189405765467924 21.331390448144674 -10.685418809746269 6.899676267990075 1.0030978113333393 0.541263457426769 0.689632957761626 0.14507276027069552 0.006942926455879516 0.0003165526175821523 0.14107259656466492 0.04682203204306206 2.0633893766752305e-11 10.685418809746269 -0.46183435390657035 TFIVGAQMNVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFIVGAQMNVK 11 0 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 0 24783100.0 4950000.0 11076000.0 8757100.0 False True 7509511.893473699 9099401.262817021 7026255.3466267185 1.0 1.2117167389700854 0.9356474090856738 22.840287707190218 -6.701769868860461 1.8242526896199156 1.1312344571564819 0.9364317133986103 0.4261585664373675 0.08933904735254784 0.39183242347187835 2.536260213333198 0.03904896914115697 0.10021620997012602 1.9871476210523675e-07 6.701769868860461 -0.19480274375787154 TFIVGAQMNVK(ub)EFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFIVGAQMNVKEFK 14 1 P46379-3;P46379;P46379-2;A0A0G2JK23;A0A024RCR6;P46379-5;A0A0G2JL47;P46379-4;F6U341;A0A0G2JJM1;X6REW1;F6S6P2;F6TC96;F6WML8;F6VEM6;F6X9W3;A0A1B0GX79;A0A0G2JJR8;F6XTU0;F6U1F2;F6UR09 P46379-3 BAG6;BAT3 Large proline-rich protein BAG6 1 11114800.0 3757200.0 3520800.0 3836800.0 True False 3637929.742587299 4926673.800729453 2831826.978467254 1.0 1.354252046996817 0.7784171709850712 21.794686250576454 -6.740274471580828 1.685702213252943 1.2107185268915803 0.7780635677831436 0.6060993693898565 0.14884157589269786 0.31735582789015715 1.7707904184615093 0.06984797739552906 0.1713483292546953 1.8185511816081997e-07 6.740274471580828 -0.43265495910843677 TFLASVQWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFLASVQWK 9 0 M0QZ24;O00754-2;O00754 M0QZ24 MAN2B1 Lysosomal alpha-mannosidase;Lysosomal alpha-mannosidase A peptide;Lysosomal alpha-mannosidase B peptide;Lysosomal alpha-mannosidase C peptide;Lysosomal alpha-mannosidase D peptide;Lysosomal alpha-mannosidase E peptide 0 8157600.0 2067000.0 2976900.0 3113700.0 False True 2675772.246661372 2811232.898094588 2547038.549259961 1.0 1.0506248809487555 0.9518891424477419 21.35152389285378 -6.767295502041402 1.5845244925755597 1.0291360345676952 0.9513856702109755 0.720257868640722 0.021321836259175535 0.270800949613811 1.3413458589150764 0.010608706098718395 0.02531918833499433 1.7088521846240151e-07 6.767295502041402 -0.07775036435671967 TFLFSATMTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFLFSATMTK 10 0 Q9H0S4;Q9H0S4-2;F5H1N9 Q9H0S4 DDX47 Probable ATP-dependent RNA helicase DDX47 0 5857600.0 2501300.0 1463600.0 1892700.0 False True 2421897.6006424003 2048023.1125731694 1396945.090217099 1.0 0.845627458415227 0.57679775141879 21.207706437589927 -6.96265903038226 0.3961807255387209 1.0154150345802002 0.39725446283887067 0.9998564620529254 0.0020950047914013964 0.07876458494316464 0.017719201610231442 0.0034617832560558002 0.022556461420022336 1.0897853606328118e-07 6.96265903038226 -0.6181605717413295 TFLHTVCFY ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFLHTVCFY 9 0 Q9NP77 Q9NP77 SSU72 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 0 12580300.0 3836400.0 3957200.0 4786700.0 False True 5254820.754811747 3782357.819289538 3656180.0451809936 1.0 0.7197881708574169 0.6957763577060347 22.325210123130166 -13.999999999999998 0.34796150742511806 4.402966499586599 0.6923688590697786 0.9997508047797868 0.0021800452862762265 20.45848271044055 0.18974437846984696 51.408830026313 0.007214459727065666 1.0000000000000041e-14 13.999999999999998 -3.7105976405168204 TFLLEYHNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFLLEYHNR 9 0 A0A0A0MRI2;Q9UNH7;Q9UNH7-2;G3V5X9 A0A0A0MRI2 SNX6 Sorting nexin-6;Sorting nexin-6, N-terminally processed 0 7336200.0 7336200.0 0.0 0.0 False True 9617829.243861852 0.0 0.0 1.0 0.0 0.0 23.197279881977742 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 TFLSK(ub)ILTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFLSKILTSK 10 1 Q8IY22 Q8IY22 CMIP C-Maf-inducing protein 1 30038300.0 8891300.0 9003800.0 12143200.0 True False 11656580.403471693 7660468.136537507 10886738.149799488 1.0 0.6571797106341737 0.9339564240089725 23.474641283065264 -9.92681819946474 6.325753923373691 1.000000033255597 0.7955680673215579 0.42109742729716704 0.1129936200755223 5.2963839158108787e-08 8.891327554939771e-09 0.10940561931283896 0.036468534065007545 1.1835368938430893e-10 9.92681819946474 -0.204431965934039 TFLSK(ub)ILTSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFLSKILTSK 10 1 Q8IY22 Q8IY22 CMIP C-Maf-inducing protein 1 56918800.0 11005000.0 20229100.0 25684700.0 True False 10655652.29883243 28306685.1233629 18957106.54551653 1.0 2.656494818854454 1.7790657966189187 23.34511557638291 -10.369255734052057 5.320255319302776 0.9994631556268087 2.2177803077367213 0.7197577041588044 0.35820889833115954 0.0022818726657022 0.0002705276862923291 0.34697195763445315 0.11561142480830598 4.2731119010856316e-11 10.369255734052057 1.2183171521099125 TFLSK(ub)ILTSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFLSKILTSK 10 1 Q8IY22 Q8IY22 CMIP C-Maf-inducing protein 1 28337800.0 8782900.0 10626000.0 8928900.0 True False 13324301.415998008 8729707.278683059 7164099.00132411 1.0 0.6551718552540109 0.5376716405351228 23.667556559665396 -13.999999999999998 0.15028383697831868 2.6681203903964508 0.4088189903014978 0.9995652945746328 0.004090746408712217 11.958821478557331 0.12210519810152365 5.824921074679574 0.11617259902936368 1.0000000000000041e-14 13.999999999999998 -2.259301400094953 TFLSK(ub)ILTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFLSKILTSK 10 1 Q8IY22 Q8IY22 CMIP C-Maf-inducing protein 1 34221600.0 8891300.0 7313600.0 18016700.0 True False 12178653.888347855 6990460.969158991 13761526.525583878 1.0 0.5739929086782932 1.1299710667326268 23.537851344588155 -6.7020063042400775 1.8241298187753445 0.7359833164725755 1.1283586034323367 0.42694706452021824 0.179758008628299 0.3913465767149765 2.5331035071286303 0.07858308715456543 0.20156485196107488 1.986066087315035e-07 6.7020063042400775 0.3923752869597612 TFLSK(ub)ILTSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFLSKILTSK 10 1 Q8IY22 Q8IY22 CMIP C-Maf-inducing protein 1 42173000.0 11005000.0 20304100.0 10863900.0 True False 9151145.104163034 20194717.783251677 13135491.261001794 1.0 2.2067968055784304 1.435393178830287 23.125520851817186 -10.108155940459788 4.7283647771594755 0.9999614671398219 1.8210949922165267 0.6016958529778027 0.31492421198107895 39387627.25490296 84201700.08753985 12750.238406971674 0.10780694752594619 7.795501501710582e-11 10.108155940459788 0.8211335250767048 TFLSK(ub)ILTSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFLSKILTSK 10 1 Q8IY22 Q8IY22 CMIP C-Maf-inducing protein 1 28518100.0 8782900.0 9632500.0 10102700.0 True False 11369637.186841877 9096442.907351993 8264112.262455808 1.0 0.8000644838411678 0.7268580453930311 23.438682881757845 -13.999999999999998 0.13968832072075776 1.954797653354099 0.635920153679093 0.9996041771186118 0.0022967287144840297 11.933657641923668 0.1170758011436769 3.106373629557021 0.08128016773850523 1.0000000000000041e-14 13.999999999999998 -1.318877499675006 TFLTLSLQDMASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFLTLSLQDMASR 13 0 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 0 7592700.0 4436600.0 3156100.0 0.0 False True 5816425.564095514 2685222.182381442 0.0 1.0 0.46166191809574175 0.0 22.471701398545434 -8.053111329961363 0.570240853398219 1.0173227472247652 9.938052000142503e-19 0.990008469273131 0.040847503755313465 0.11315250405780508 0.1670086259149371 0.04770105634615343 0.07546771767130718 8.848887424363813e-09 8.053111329961363 -1.0173227472247652 TFLTLSLQDMASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFLTLSLQDMASR 13 0 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 0 27426800.0 11261000.0 8303400.0 7862400.0 False True 10903525.718959756 11618990.921658963 5803001.5730559165 1.0 1.0656177846634607 0.5322133154567867 23.37829137855221 -6.876112808087025 1.1013011794628662 1.0389056632298972 0.49712726808718766 0.9704099399980156 0.04085394801198774 0.13112654943178945 0.2935976942522693 0.02866981107483007 0.0686930271715751 1.330108877030028e-07 6.876112808087025 -0.5417783951427095 TFLTLSLQDMASR ddPTM_RPMI8226_Bortezomib_8h_R1 2 TFLTLSLQDMASR 13 0 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 0 78845200.0 24665000.0 19713200.0 34467000.0 False True 37418608.25303614 16195225.440065386 27654582.342577208 1.0 0.43281207388976867 0.7390596185611291 25.15725256421774 -10.100407820524872 5.35550254972027 1.0000062994034455 0.5859358462251907 0.7090833803569199 0.1250250365717918 9.403730277361843e-06 1.5797507343882032e-06 0.12105681213252642 0.04035165704165579 7.935826776873548e-11 10.100407820524872 -0.41407045317825486 TFLTLSLQDMASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFLTLSLQDMASR 13 0 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 0 12472100.0 4436600.0 2027200.0 6008300.0 False True 6076930.914606865 1937631.6009460597 4589263.284822732 1.0 0.31885035854014 0.755194250076418 22.534911460068326 -10.178604242450776 6.502671379124351 1.0000021100531058 0.5370223043088211 0.6001711973524222 0.17813664777403607 5.449370323435327e-06 6.881291442178169e-07 0.17248085383862868 0.05749335584817131 6.628202337483179e-11 10.178604242450776 -0.46297980574428466 TFLTLSLQDMASR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TFLTLSLQDMASR 13 0 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 0 34910500.0 18903200.0 7577500.0 8429800.0 False True 15718848.353749653 7536678.503484014 10192432.20500859 1.0 0.47946760054378773 0.648421053224121 23.90599218618484 -10.293352778089274 5.258343007715094 1.0000838973924004 0.5639443268839104 0.8988012402610418 0.06897495822486861 6.785376989247242e-05 9.118606425664186e-06 0.06679749612499372 0.02226157204249996 5.089173087826254e-11 10.293352778089274 -0.43613957050849006 TFLTLSLQDMASR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TFLTLSLQDMASR 13 0 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 0 91992800.0 24665000.0 41744800.0 25583000.0 False True 31929328.71983685 39421665.18337157 20927156.5037472 1.0 1.2346537419961459 0.6554211235498261 24.92837888631019 -6.796742503388456 1.4693081761930034 1.1300071900148367 0.6480651131155645 0.8224365695336272 0.10024102625518568 0.22543708607281648 0.9611666982290058 0.053681514431812107 0.12509198122315757 1.59682563708843e-07 6.796742503388456 -0.48194207689927226 TFLTVYWTPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFLTVYWTPER 11 0 P05362;K7EKL8 P05362 ICAM1 Intercellular adhesion molecule 1 0 8200000.0 2623100.0 4429400.0 1147500.0 False True 3438909.5021365373 3768550.785665966 1028767.7075972473 1.0 1.0958563414723848 0.2991552138717495 21.713519719926673 -6.8768371033923215 1.0972294206130035 1.057260356763491 0.2459967813329019 0.971045994289384 0.06042977836370586 0.13047145389399592 0.2894977574404773 0.04253753453142178 0.10209391437859539 1.3278924346096308e-07 6.8768371033923215 -0.8112635754305891 down TFLTVYWTPER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFLTVYWTPER 11 0 P05362;K7EKL8 P05362 ICAM1 Intercellular adhesion molecule 1 0 18414700.0 9008600.0 4675100.0 4731000.0 False True 8722626.924058333 6541891.810324421 3491809.173042265 1.0 0.7499910138631388 0.4003162354005218 23.056331254736346 -6.966393756951604 0.3332668247966153 1.0410109647984378 0.09779306010508917 0.9999390587756056 0.0019199523710889204 0.0774911346464766 0.013209410590029025 0.005044616276356748 0.030420437067123048 1.0804539039467188e-07 6.966393756951604 -0.9432179046933487 down TFLTVYWTPER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFLTVYWTPER 11 0 P05362;K7EKL8 P05362 ICAM1 Intercellular adhesion molecule 1 0 44067000.0 13922000.0 15947000.0 14198000.0 False True 21120691.834533513 13101133.255520292 11391759.076795543 1.0 0.6202984901327525 0.539364863899457 24.332153756952568 -13.999999999999998 0.2172486461077322 3.264034340878282 0.49491523586025593 0.999495289720094 0.004511260084677977 12.92621141183096 0.14767880510228193 12.537083776009656 0.04561758942356537 1.0000000000000041e-14 13.999999999999998 -2.769119105018026 TFLTVYWTPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFLTVYWTPER 11 0 P05362;K7EKL8 P05362 ICAM1 Intercellular adhesion molecule 1 0 16045100.0 2623100.0 3982700.0 9439300.0 False True 3592930.95661211 3806731.144972319 7209931.748485798 1.0 1.059505788155141 2.006699220094191 21.776729781449564 -6.919716934785288 0.8268257412999078 0.978887012881828 2.1584515473425374 0.9941019123624824 0.03541795073040869 0.09833849846775077 0.10648005426223237 0.030470565792111506 0.09102799233058198 1.203048304055191e-07 6.919716934785288 1.1795645344607095 up TFLTVYWTPER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFLTVYWTPER 11 0 P05362;K7EKL8 P05362 ICAM1 Intercellular adhesion molecule 1 0 16696300.0 9008600.0 3715800.0 3971900.0 False True 7491050.048647273 3695782.2478714515 4802405.926009353 1.0 0.4933597057649925 0.6410858150489286 22.836736530170622 -10.687085440711659 10.167972965548715 1.0002848115734801 0.5672227604069763 0.9196357650246034 0.06030893157204471 0.0003896208958101431 1.1990339235290956e-05 0.05842970189739578 0.019464623967174327 2.055486171140648e-11 10.687085440711659 -0.43306205116650387 TFLTVYWTPER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFLTVYWTPER 11 0 P05362;K7EKL8 P05362 ICAM1 Intercellular adhesion molecule 1 0 45242000.0 13922000.0 15635000.0 15685000.0 False True 18022303.443647623 14764898.50573042 12830490.941690745 1.0 0.8192570140602449 0.7119229227168045 24.103280079045017 -13.9999999911441 0.05476130518129073 2.2234817913486644 0.16167097060272614 0.9999664359518703 0.0006886602280329888 12.517474726622781 0.057796422555205 2.20284351629957 0.5213264054792652 1.0000000203914615e-14 13.9999999911441 -2.0618108207459382 TFLVGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFLVGER 7 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 39534600.0 6899600.0 17397000.0 15238000.0 False True 9045442.415821454 14801435.412974877 13661317.933217306 1.0 1.6363417876703932 1.510298480185136 23.10875963662645 -10.195035773799345 4.485913080779323 0.9998613305222823 1.5733201339367275 0.9650182143208527 0.05145696484839177 36155528.01999137 13.633952928246476 52436.974477259624 0.017615087736107125 6.382109131774097e-11 10.195035773799345 0.5734588034144452 TFLVGER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFLVGER 7 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 33249500.0 9594700.0 7579800.0 16075000.0 False True 9290121.500373248 10606453.668134818 11864475.260337016 1.0 1.1416915987276037 1.277106576039973 23.147266034267915 -6.971676462184271 0.2144052364234078 0.9329681480886686 1.489629161551577 0.9999926689894916 0.00030627610271967236 0.07576245914236171 0.007050379613304836 0.003916761854183314 0.013892722841404923 1.0673910029634987e-07 6.971676462184271 0.5566610134629085 TFLVGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFLVGER 7 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 111205000.0 27358000.0 68459000.0 15388000.0 False True 41504086.137707755 56241956.57739162 12346555.055200007 1.0 1.3550944451778701 0.29747806069587873 25.30675004309061 -6.816167742281929 1.3884443926840215 1.1921688258120855 0.2762474036582144 0.8753144177456447 0.1551795301600793 0.19851669201027738 0.7529967967240843 0.08785125535502736 0.20271194632865291 1.5269761637108108e-07 6.816167742281929 -0.9159214221538712 down TFLVGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFLVGER 7 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 33605600.0 6899600.0 11114000.0 15592000.0 False True 9450568.574679164 10622946.730916802 11909490.727319865 1.0 1.12405371665984 1.2601877477751837 23.17196969814934 -6.969931637305832 0.2598149998994897 0.961693832956367 1.4265855412856403 0.9999818413552007 0.0004527657894960381 0.0763249105038566 0.00910954663725146 0.0028452303683312473 0.012848024657592839 1.0716879873536414e-07 6.969931637305832 0.4648917083292733 TFLVGER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFLVGER 7 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 24486800.0 9594700.0 11136000.0 3756100.0 False True 7978418.1672797045 11076008.15767707 4541483.143755817 1.0 1.3882461316832067 0.5692209970117756 22.92767130970219 -6.777796647399512 1.5443350396685944 1.2204690825843036 0.5631637669409927 0.7595279349725099 0.16403972662172295 0.2540283467213124 1.1964938643133705 0.08367206975711267 0.1978075916496238 1.6680280616249244e-07 6.777796647399512 -0.657305315643311 TFLVGER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFLVGER 7 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 67679000.0 27358000.0 19699000.0 20622000.0 False True 35415470.30680299 18602733.33318732 16869007.59958856 1.0 0.5252713904977822 0.4763174808481417 25.07787636518306 -13.999999999999998 0.3210231224653102 5.897289190057427 0.466709210847867 0.999695918010758 0.00411840076019556 18.09307420493576 0.18073704110445113 59.54344653698076 0.016233556234192276 1.0000000000000041e-14 13.999999999999998 -5.43057997920956 TFMIQIAVLANHQNGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFMIQIAVLANHQNGR 16 0 D6RA92;Q9UM13 D6RA92 ANAPC10 Anaphase-promoting complex subunit 10 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 TFNCGVGAVLVVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFNCGVGAVLVVSK 14 0 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 16978800.0 4573400.0 5947700.0 6457700.0 False True 5995771.688868604 5060326.34395302 5789519.1506324615 1.0 0.8439824940879126 0.9656003348794854 22.51551401771865 -10.269007905524411 5.267460271712187 1.0000134339357023 0.9047914145558482 0.44968461757941036 0.04965027559310928 7.834099016713042e-06 1.0871867718209989e-06 0.04808045467998682 0.01602455754222046 5.3825998440382525e-11 10.269007905524411 -0.09522201937985408 TFNCGVGAVLVVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFNCGVGAVLVVSK 14 0 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 72195000.0 16182000.0 33626000.0 22387000.0 False True 24549277.062664937 27625177.578862827 17962199.637429338 1.0 1.1252949530182208 0.7316793725362541 24.549177204292643 -6.82108356643103 1.367190016750691 1.067459801436291 0.722885542386866 0.8868577164554465 0.055228300704991566 0.19207523914147703 0.7051766151529981 0.0317415598270928 0.07313849969211701 1.5097896142788161e-07 6.82108356643103 -0.34457425904942507 TFNCGVGAVLVVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFNCGVGAVLVVSK 14 0 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 16606700.0 4573400.0 5468500.0 6564800.0 False True 6264309.5714878645 5226883.588088759 5014329.446299996 1.0 0.8343910096459838 0.8004600329975423 22.578724079241542 -13.999999999686572 0.22284309409595435 2.011994325714195 0.7827974374710535 0.9995008963885852 0.0019475145508681742 13.078571383676863 0.14952428652128052 5.83317369376321 0.018432356605426813 1.0000000007216935e-14 13.999999999686572 -1.2291968882431412 TFNCGVGAVLVVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFNCGVGAVLVVSK 14 0 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 13113400.0 5546200.0 1473400.0 6093800.0 False True 4611911.038319769 1465462.5017529996 7367985.405452253 1.0 0.31775602121911334 1.5975992043715979 22.136933253646742 -6.7619122558755995 1.605485707648161 0.6046549097388862 1.6026869480009205 0.6986472045947096 0.2870351759612133 0.2797155974042075 1.4214529617187 0.14103973842783066 0.3382748761777897 1.7301658837013242e-07 6.7619122558755995 0.9980320382620342 TFNCGVGAVLVVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFNCGVGAVLVVSK 14 0 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 50823000.0 16182000.0 20805000.0 13836000.0 False True 20947917.994907755 19647183.460935183 11317989.969348628 1.0 0.9379062618877557 0.5402918787489968 24.320303526385093 -6.934474283167058 0.7091090845582035 1.0051605767777727 0.4485133446268691 0.9973467492391411 0.0104902959598076 0.0903804812364886 0.06678200751845828 0.009825621727469676 0.03513441130912856 1.1628554076757392e-07 6.934474283167058 -0.5566472321509036 TFNIK(ub)NDFTEEEEAQVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFNIKNDFTEEEEAQVR 17 1 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 22633300.0 5729200.0 12586200.0 4317900.0 True False 7511036.681651728 10708388.020623347 3871125.1282214904 1.0 1.4256870888118869 0.5153915887107882 22.84058061318355 -6.7795651815023605 1.537730586657332 1.2411763283427508 0.5083016278883999 0.7657694437685945 0.1799830439410343 0.2512641714685222 1.173546687730105 0.0921923950848375 0.2175994866119425 1.661249328862104e-07 6.7795651815023605 -0.7328747004543509 TFNIK(ub)NDFTEEEEAQVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFNIKNDFTEEEEAQVR 17 1 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 57433000.0 22089000.0 18641000.0 16703000.0 True False 21387796.7859073 26084448.511530783 12327983.220740858 1.0 1.2195949294187314 0.5764026722408326 24.350284538497746 -6.814546117644467 1.3951819834653354 1.1190514428890324 0.5639234548504563 0.8714100583915915 0.09572619102428413 0.20066008261253548 0.7688854684841597 0.053934853475210355 0.12453494720211089 1.53268844184099e-07 6.814546117644467 -0.5551279880385761 TFNIK(ub)NDFTEEEEAQVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFNIKNDFTEEEEAQVR 17 1 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 98394700.0 18177000.0 51801700.0 28416000.0 True False 27575837.916701324 42557281.90647054 22799565.144824743 1.0 1.5432815508643416 0.8267950085033018 24.716901388283983 -6.703905141809089 1.8166120980736598 1.3360445181289426 0.8287370634438183 0.4363225018529687 0.22916465849640938 0.3874314306565401 2.488228064878775 0.10053077168262191 0.2573313434138566 1.9774014951160327e-07 6.703905141809089 -0.5073074546851244 TFNIK(ub)NDFTEEEEAQVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFNIKNDFTEEEEAQVR 17 1 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 28248700.0 5729200.0 10031000.0 12488500.0 True False 7847440.065808432 9587797.251918865 9538973.508731024 1.0 1.2217738742208724 1.2155522601940807 22.903790674706443 -10.063003239528053 4.767246261500866 0.999992537560988 1.2186630672112746 0.9993931866107978 0.0025399633034214526 1761557.5570112688 0.07508296557532886 144.29882333376034 0.0008694969958585713 8.649614667540731e-11 10.063003239528053 0.21867052965028655 TFNIK(ub)NDFTEEEEAQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFNIKNDFTEEEEAQVR 17 1 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 53478000.0 22089000.0 20863000.0 10526000.0 True False 18367982.208619494 20750606.87801875 12726937.933274863 1.0 1.1297161899623993 0.6928871004297101 24.130689813932023 -6.827140238925166 1.340545484073935 1.0694636319675652 0.6817975064606203 0.9000382968269797 0.05791263832956311 0.18437702018498425 0.6489923500409295 0.03392800832456862 0.07809689182667735 1.4888802227005147e-07 6.827140238925166 -0.3876661255069449 TFNIK(ub)NDFTEEEEAQVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFNIKNDFTEEEEAQVR 17 1 E5RJR5;P63208 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 89472000.0 18177000.0 49987000.0 21308000.0 True False 23530484.82223696 47205179.50789547 17430162.638543 1.0 2.006128639699139 0.7407481303602811 24.488027710376432 -6.694884309573574 1.849392288946837 1.6278744883318503 0.7448838683237616 0.3932683612553821 0.42510939609365994 0.40623155550201406 2.697542959170952 0.18364847133044887 0.47525169964679576 2.0189041019656847e-07 6.694884309573574 -0.8829906200080887 TFNLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFNLEK 6 0 Q15233;C9JYS8;C9IZL7;C9J4X2;C9JJ13 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 10355900.0 3405300.0 2979900.0 3970700.0 False True 3297200.615466978 4169789.609973213 2930654.5515533607 1.0 1.2646454056853473 0.888831130810127 21.65281023859944 -6.71743940839133 1.7682566617786348 1.1614403288644075 0.8894877267340109 0.5005682637974249 0.11139965916062812 0.3602969775001221 2.200177634470401 0.050047190190922 0.1260300763742828 1.9167284609281752e-07 6.71743940839133 -0.2719526021303966 TFNLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFNLEK 6 0 Q15233;C9JYS8;C9IZL7;C9J4X2;C9JJ13 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 40927400.0 9247700.0 25797000.0 5882700.0 False True 14029436.997429628 21193323.797119018 4719981.76652099 1.0 1.5106325222460393 0.33643415394258164 23.741953778849055 -6.788521064751537 1.502313461302489 1.2859458593819908 0.3244642785550267 0.7964603869769711 0.21687761893152172 0.23757135759335452 1.0592897379021187 0.11364143918139942 0.2663431662070021 1.6273423821173475e-07 6.788521064751537 -0.9614815808269641 down TFNLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFNLEK 6 0 Q15233;C9JYS8;C9IZL7;C9J4X2;C9JJ13 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 8331700.0 3405300.0 3412900.0 1513500.0 False True 2831657.830368596 3394514.030292393 1829965.8523666642 1.0 1.1987726743984919 0.6462524648073239 21.433215514033716 -6.809383502335602 1.4169592649278147 1.108408662414681 0.6367061513301914 0.8582576318968901 0.08602873640779049 0.20763802238579962 0.82174541658181 0.04773939633393665 0.11047062621868142 1.5510167847125086e-07 6.809383502335602 -0.4717025110844896 TFNLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFNLEK 6 0 Q15233;C9JYS8;C9IZL7;C9J4X2;C9JJ13 Q15233 NONO Non-POU domain-containing octamer-binding protein 0 25021700.0 9247700.0 6392800.0 9381200.0 False True 11971329.949419616 6037035.060277165 7673917.859240635 1.0 0.5042910926174787 0.6410246724185124 23.513080100941504 -10.443678709992097 9.09598744703264 1.0000037194971234 0.5726578825180142 0.928692962212071 0.05582125020277617 4.2105235071538665e-06 2.575767951345385e-07 0.05404916312005221 0.018016231033319122 3.600155753140473e-11 10.443678709992097 -0.4273458369791092 TFNLEK(ub)QNHTPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFNLEKQNHTPR 12 1 Q15233;C9JYS8;C9IZL7;C9J4X2;C9JJ13 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 6274100.0 1611300.0 2752300.0 1910500.0 True False 1560150.1634810264 3851307.7430548887 1410082.7362285478 1.0 2.468549395567029 0.9038121901563332 20.573253463593318 -6.6604690471008245 1.9711230874032304 1.9449289078016372 0.9103214386077554 0.23759710233866405 0.6252065924044523 0.48336335271364766 3.6106917879054343 0.2562071424294084 0.6931519594598959 2.185400071246657e-07 6.6604690471008245 -1.0346074691938818 TFNLEK(ub)QNHTPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFNLEKQNHTPR 12 1 Q15233;C9JYS8;C9IZL7;C9J4X2;C9JJ13 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 3800800.0 1419100.0 1283100.0 1098600.0 True False 1943779.6197355187 1226408.3993557072 839133.30637722 1.0 0.630940044284742 0.4317018749745905 20.89043322883492 -10.877362315667467 0.11214778979708688 1.9683374467409727 1.6664569695078956e-16 0.9998536381126861 0.00284828127128608 3.050012853191116 0.0653688809715741 1.0476440994473049 0.27710327017211445 1.3262875239063538e-11 10.877362315667467 -1.9683374467409724 TFNLEK(ub)QNHTPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFNLEKQNHTPR 12 1 Q15233;C9JYS8;C9IZL7;C9J4X2;C9JJ13 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 7205800.0 1611300.0 4484700.0 1109800.0 True False 1339867.3426931305 4460540.03095675 1341854.0488645681 1.0 3.3290907904293525 1.0014827633364392 20.353658739027594 -6.646060111012533 2.023150122114721 2.5160492277715383 1.0113349369766955 0.17811975601541086 0.9950530470870117 0.5181794032643099 4.060973850367776 0.39956272080941163 1.1016283848993509 2.2591230617277065e-07 6.646060111012533 -1.5047142907948428 TFNLEK(ub)QNHTPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFNLEKQNHTPR 12 1 Q15233;C9JYS8;C9IZL7;C9J4X2;C9JJ13 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 12822800.0 2886500.0 3918400.0 6017900.0 True False 3736631.151421407 3700337.5954495766 4922703.948868402 1.0 0.9902870916338574 1.3174176816986114 21.833306729436117 -6.900059440743291 0.9609178949162929 0.986421239469511 1.3517938752183263 0.9865950838646212 0.017595398424055636 0.11136074891942563 0.17718452059510134 0.013732197774384074 0.03573848302935767 1.2587531177757434e-07 6.900059440743291 0.3653726357488153 TFNLIPAVGLNVHSMLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFNLIPAVGLNVHSMLK 17 0 K7ES61;Q9BYD3 K7ES61 MRPL4 39S ribosomal protein L4, mitochondrial 0 36988000.0 11399000.0 12554000.0 13035000.0 False True 17293116.378526594 10313640.615150318 10458626.536556538 1.0 0.5964015038930224 0.6047855289717095 24.04369454352792 -10.210210380882778 5.400092851970671 1.0000217009044 0.6005935164323122 0.9996696350868887 0.003422763905769383 8.942941680637212e-07 1.3079617174093817e-07 0.0033142567137111295 0.0011046923003930086 6.162963833160957e-11 10.210210380882778 -0.3994281844720877 TFNLIPAVGLNVHSMLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TFNLIPAVGLNVHSMLK 17 0 K7ES61;Q9BYD3 K7ES61 MRPL4 39S ribosomal protein L4, mitochondrial 0 47508600.0 17558300.0 14417900.0 15532400.0 False True 22729565.47583665 13615531.19064732 12705662.575882532 1.0 0.5990229423928813 0.5589927616253672 24.43806676843559 -13.999999999999975 0.32572400220798964 5.2542068863289995 0.5515435439065012 0.9997058978601783 0.003414944878173916 18.468318809588713 0.1822794571541386 53.7041074941953 0.013036160436820128 1.0000000000000573e-14 13.999999999999975 -4.702663342422499 TFNPGAGLPTDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFNPGAGLPTDK 12 0 P09661;H0YMA0;H0YLR3 P09661 SNRPA1 U2 small nuclear ribonucleoprotein A 0 9836900.0 2261200.0 1553100.0 6022600.0 False True 2189419.443718303 2173260.9293095046 4445100.385872834 1.0 0.9926197264506995 2.0302644149006444 21.062116938372046 -6.90529559397644 0.927157176685296 0.9628992863058415 2.151706276059413 0.9890222634413826 0.05106929817304497 0.10761265032412279 0.15624264738300436 0.04086190233508251 0.10944133958711903 1.2436678456380948e-07 6.90529559397644 1.1888069897535716 up TFNQVEIKPEMIGHYLGEFSITYKPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFNQVEIKPEMIGHYLGEFSITYKPVK 27 2 P62841;K7EM56;S4R417;K7ELC2;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 0 32269300.0 21505000.0 7404400.0 3359900.0 False True 20822335.546241846 10361015.533435894 2479841.3951605815 1.0 0.49759142102125614 0.11909525661294801 24.311628562436002 -8.102035179927753 0.38412485516129663 1.0753103167880975 4.28226233239874e-20 0.9976413633242265 0.017523115551881237 0.0950865649259289 0.08930539855869624 0.05638609284368843 0.08398825270887302 7.906145818477703e-09 8.102035179927753 -1.0753103167880975 TFNQVEIKPEMIGHYLGEFSITYKPVK ddPTM_RPMI8226_Bortezomib_8h_R1 2 TFNQVEIKPEMIGHYLGEFSITYKPVK 27 2 P62841;K7EM56;S4R417;K7ELC2;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 0 1654814700.0 494382000.0 705834000.0 454598700.0 False True 750013638.1655178 579872407.9937867 364747067.68731165 1.0 0.773149151543584 0.48632058022232516 29.482341588753908 -6.967940995665226 0.3033627031735269 1.0477989703333275 0.20263999672234947 0.9999615739189776 0.001302896411699423 0.07697662430980463 0.01140887184237763 0.00468100045906135 0.02563422391487695 1.0766114748222023e-07 6.967940995665226 -0.845158973610978 down TFNQVEIKPEMIGHYLGEFSITYKPVK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TFNQVEIKPEMIGHYLGEFSITYKPVK 27 2 P62841;K7EM56;S4R417;K7ELC2;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 0 146118560.0 68382300.0 36719360.0 41016900.0 False True 56862912.29953735 36521545.519457676 49593344.149282046 1.0 0.6422735671200369 0.8721562463779321 25.760984654407146 -10.666456258784482 6.137945720341005 1.0021774522450664 0.7572149067489846 0.597941955104675 0.09384921081428825 0.002818846130460064 0.0001531794718509146 0.09159747880768937 0.030289702544870612 2.1554787278618674e-11 10.666456258784482 -0.24496254549608176 TFNQVEIKPEMIGHYLGEFSITYKPVK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TFNQVEIKPEMIGHYLGEFSITYKPVK 27 2 P62841;K7EM56;S4R417;K7ELC2;A0A0B4J2B4 P62841;A0A0B4J2B4 RPS15 40S ribosomal protein S15 0 1172709000.0 494382000.0 461118400.0 217208600.0 False True 639987244.7261451 435456755.6843493 177678863.54844314 1.0 0.6804147415011126 0.2776287574676166 29.253467910846357 -7.225926711165791 0.3493695561681627 1.0473803065211555 2.5486958653775738e-14 0.9998105615331669 0.004067958977108758 0.09287556099907984 0.021744023967451453 0.009685448473463983 0.04411706990964933 5.9439245612461244e-08 7.225926711165791 -1.04738030652113 down TFNTSTGGLLLPSDTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFNTSTGGLLLPSDTK 16 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 26913000.0 4716800.0 9853200.0 12343000.0 False True 6183770.477556173 8383140.967472775 11065864.762416419 1.0 1.3556681959492445 1.7895012116927165 22.560055341200666 -6.968465844975112 0.2925193116297028 0.9177460796176108 2.240874263895782 0.9999678197436606 0.0018313784815487259 0.07680372599610454 0.010802764899585019 0.007478308272911422 0.03922865436106979 1.0753111647539066e-07 6.968465844975112 1.323128184278171 TFNTSTGGLLLPSDTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFNTSTGGLLLPSDTK 16 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 23357800.0 6715400.0 4366400.0 12276000.0 False True 6502223.302824109 6109926.290475197 9060547.327894071 1.0 0.9396672500960517 1.3934537320425162 22.632501672006555 -6.8733960336142275 1.115921958529582 0.9650629206638648 1.42180912926062 0.9679591295544835 0.03601646110002046 0.13364299933714113 0.3089791256569794 0.024991926274683905 0.05954648275997474 1.3384555916297058e-07 6.8733960336142275 0.4567462085967553 TFNTSTGGLLLPSDTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFNTSTGGLLLPSDTK 16 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 22709600.0 4716800.0 8676300.0 9316500.0 False True 6460728.426727146 8292952.377312703 7116134.5793404 1.0 1.2835940206070107 1.1014446219255911 22.623265402723558 -10.28915888270656 4.006736542813457 0.9997269006307148 1.1925193212822924 0.5983081470115845 0.0743621806736714 6943467.43177863 17830646.88260987 9524.278822258437 0.02545615119883295 5.1385562775924e-11 10.28915888270656 0.19279242065157765 TFNTSTGGLLLPSDTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFNTSTGGLLLPSDTK 16 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 16782700.0 6715400.0 5121800.0 4945500.0 False True 5584152.642662105 5094207.846802304 5979581.184591575 1.0 0.9122615681891115 1.0708126312501656 22.41290694744083 -6.756467116976884 1.6255128635437233 0.9488137810687133 1.071297853226852 0.6764715382589301 0.03688697977927603 0.28889846068801267 1.5036019297996404 0.017910859805027858 0.04319849511696786 1.7519950831742843e-07 6.756467116976884 0.12248407215813872 TFNTSTGGLLLPSDTK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFNTSTGGLLLPSDTKR 17 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 45513000.0 12210000.0 19444000.0 13859000.0 True False 16007428.241808213 16543030.99211837 12425003.62491526 1.0 1.0334596377518825 0.7762023628794803 23.932238206867726 -6.874185677870849 1.1116526150037491 1.019500657029207 0.759883106949651 0.9686880449890742 0.020208887553406288 0.1329080506182199 0.3044360305589851 0.014068918508179042 0.033574676138311804 1.3360241918460804e-07 6.874185677870849 -0.2596175500795559 TFNTSTGGLLLPSDTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFNTSTGGLLLPSDTKR 17 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 132361000.0 34517000.0 32558000.0 65286000.0 True False 33421276.728650548 45558579.18772699 48185638.0619822 1.0 1.3631609455742808 1.4417653297091082 24.994263511162714 -12.320364332316554 0.24301011401896458 1.5573920624384224e-13 1.4781332542964862 0.9994063950489704 0.004688062992832332 6.097881119735233 0.14596455520241483 3.0477945179400243 0.037691026176829186 4.782287349634708e-13 12.320364332316554 1.4781332542963306 TFNTSTGGLLLPSDTK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFNTSTGGLLLPSDTKR 17 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 138972000.0 17842000.0 16540000.0 104590000.0 True False 27067618.424920782 13588307.772390144 83917740.65657446 1.0 0.502013422794507 3.1003001202097837 24.690064620190455 -6.8570485612426575 1.2004717198183588 0.7316359802716076 3.2192611683146857 0.9499570060908127 0.2518835322681642 0.14987786892625524 0.4121072837157962 0.1638277225712777 0.38126205996081225 1.3897972204119777e-07 6.8570485612426575 2.487625188043078 up TFNTSTGGLLLPSDTK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFNTSTGGLLLPSDTKR 17 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 63587000.0 12210000.0 25933000.0 25444000.0 True False 16724366.96284315 24787194.311037026 19434651.235628977 1.0 1.482100600047058 1.162056015561445 23.995448268390618 -10.413687571431206 5.487344526967759 0.9998047175658954 1.3220783078042537 0.5745282854875903 0.1306576544884764 0.00031233635427871923 3.337262204952529e-05 0.1265846582623549 0.042169576657364906 3.857557680102948e-11 10.413687571431206 0.32227359023835833 TFNTSTGGLLLPSDTK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFNTSTGGLLLPSDTKR 17 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 108606000.0 34517000.0 43283000.0 30806000.0 True False 28702414.862371262 43049825.887997165 37247392.16914935 1.0 1.4998677321898546 1.297709351207954 24.77466878659699 -10.174697659393518 4.451089006220337 0.9999208158404326 1.3987885417074912 0.8384095650367873 0.0825308135315326 6.928174384874087e-05 1.2845842309618916e-05 0.07992700145425026 0.026636705516105124 6.688093571868549e-11 10.174697659393518 0.39886772586705865 TFNTSTGGLLLPSDTK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFNTSTGGLLLPSDTKR 17 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 144648000.0 17842000.0 25896000.0 100910000.0 True False 23096820.71839973 24454864.835586518 82545415.42403658 1.0 1.0587978810479715 3.5738864855230066 24.461190942282904 -6.911935666441432 0.8824568333248278 0.9268118072272621 3.9127365464127597 0.9916314409363473 0.10975046300253637 0.10315223755897887 0.13193035339180129 0.09072271360662165 0.2539228130064489 1.2247976193770187e-07 6.911935666441432 2.9859247391854975 up TFNTSTGGLLLPSDTKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFNTSTGGLLLPSDTKR 17 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 22425400.0 6372600.0 6758300.0 9294500.0 False True 8354540.312346188 5749987.983647067 8332794.299139538 1.0 0.6882470810691809 0.9973971023666599 22.99412901911353 -10.899154437814284 9.946039906622822 1.0156090876156139 0.8428220917179498 0.25631420263853244 0.12620996769156267 0.04259978543875347 0.0004319299865870001 0.11916901359467941 0.04073409191623319 1.2613789006579618e-11 10.899154437814284 -0.1727869958976641 TFNTSTGGLLLPSDTKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFNTSTGGLLLPSDTKR 17 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 19400000.0 6029100.0 3972800.0 9398100.0 False True 5837709.520662493 5559159.757878302 6936455.673043446 1.0 0.9522844084998974 1.1882152834929445 22.476970994702572 -6.854077260256669 1.2153535245784624 0.9744200991544804 1.1984098858355925 0.946016203324914 0.023664800168854146 0.15303168722611282 0.432949115385641 0.015219419486518566 0.035320821685547274 1.39933836049146e-07 6.854077260256669 0.22398978668111214 TFNTSTGGLLLPSDTKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFNTSTGGLLLPSDTKR 17 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 83388000.0 18248000.0 48767000.0 16373000.0 False True 27683550.107496597 40064147.83168995 13136869.37345917 1.0 1.4472185711774275 0.4745370200876714 24.72252562864802 -6.78169063567771 1.5292966714692668 1.2526700212464466 0.46642117284348145 0.7733233001319111 0.1892632831383119 0.2479560729845241 1.145528234308029 0.09746437577064082 0.22965088412512394 1.65313897208141e-07 6.78169063567771 -0.786248848402965 down TFNTSTGGLLLPSDTKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFNTSTGGLLLPSDTKR 17 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 17629200.0 6372600.0 5801900.0 5454700.0 False True 8728722.433039656 5545552.873682393 4166412.203072844 1.0 0.6353223986927983 0.47732210928168434 23.05733908063642 -13.999999999994825 0.11392204254260127 2.7490260780425455 0.20318098225316525 0.9997232083831286 0.0036413871679671582 11.99101568218138 0.10304081589049563 4.791005152122231 0.24331393855944278 1.0000000000119148e-14 13.999999999994825 -2.5458450957893803 TFNTSTGGLLLPSDTKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFNTSTGGLLLPSDTKR 17 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 12992300.0 6029100.0 4167100.0 2796100.0 False True 5013463.784417035 4144651.005195409 3380751.582294307 1.0 0.8267040879158059 0.6743344975987337 22.25737627013685 -6.972638552201728 0.18458835348974373 1.110863333593611 0.3860358607022623 0.9999963169908589 0.00025526139082473727 0.07545553723995065 0.005851759630679675 0.005636032699979901 0.016867312394672995 1.0650290351304407e-07 6.972638552201728 -0.7248274728913486 TFNTSTGGLLLPSDTKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFNTSTGGLLLPSDTKR 17 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 47154000.0 18248000.0 14439000.0 14467000.0 False True 23622395.72185619 13635456.95709892 11834154.443955384 1.0 0.5772258291517385 0.5009718143450644 24.49365195074047 -13.999999999999998 0.24089851313591804 3.8105933328019983 0.4675426148775475 0.9995264593579504 0.004776310828491448 13.655256408625213 0.15533866140969121 18.472393338503142 0.03706476402659049 1.0000000000000041e-14 13.999999999999998 -3.343050717924451 TFPTHPYFSAQLGAGQLSLYNILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFPTHPYFSAQLGAGQLSLYNILK 24 0 H0Y8P0;Q86TI0-2;Q86TI0;A0JNU9 H0Y8P0 TBC1D1 TBC1 domain family member 1 0 72477000.0 21813000.0 25298000.0 25366000.0 False True 33091915.74390744 20783374.245823827 20352398.98168725 1.0 0.6280498961336277 0.6150263145594506 24.97997547820203 TFQGHTNEVNAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFQGHTNEVNAIK 13 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3;O60907;O60907-2;Q9BQ87;A0A2R8YFW3 Q9BZK7 TBL1XR1;TBL1X;TBL1Y F-box-like/WD repeat-containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1X;F-box-like/WD repeat-containing protein TBL1Y 0 6960800.0 2422500.0 4538300.0 0.0 False True 3318163.715600938 4337782.899848813 0.0 1.0 1.307284170293935 0.0 21.661953638818293 -6.880950181285402 1.3379657505272575 1.1604210044428922 1.6070033143671329e-18 0.9311938163514744 0.14639836023887548 0.1481314477589768 0.5330328491989201 0.08879686224970067 0.18075480245102318 1.3153757126927786e-07 6.880950181285402 -1.1604210044428922 down TFQGHTNEVNAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFQGHTNEVNAIK 13 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3;O60907;O60907-2;Q9BQ87;A0A2R8YFW3 Q9BZK7 TBL1XR1;TBL1X;TBL1Y F-box-like/WD repeat-containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1X;F-box-like/WD repeat-containing protein TBL1Y 0 58560000.0 10704000.0 18539000.0 29317000.0 False True 13856539.007384308 17507288.352909245 23981606.81782264 1.0 1.2634676194091043 1.7307068384856108 23.724063620069796 -6.96232628305802 0.4013044561182723 0.9746819077800047 2.036589264329938 0.9998469846233516 0.003737591895846461 0.07888035527921189 0.018135980133446285 0.006011187471563769 0.03912812192273741 1.0906206512719498e-07 6.96232628305802 1.0619073565499333 TFQGKPIK(ub)AR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFQGKPIKAR 10 2 Q92615 Q92615 LARP4B La-related protein 4B 1 2872450.0 777550.0 1081900.0 1013000.0 True False 1019375.5798049115 920484.7372131702 908184.4773821465 1.0 0.9029888055483268 0.8909223404743081 19.959254266843978 -13.999999998543393 0.29395394836206873 1.854854084089194 0.8877632434487636 0.9996363004254087 0.0009311145056564731 16.205318046956673 0.1720271477041639 8.396596184246054 0.004477351828185717 1.0000000033539622e-14 13.999999998543393 -0.9670908406404305 TFQNSLIHLGLNTMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFQNSLIHLGLNTMK 15 0 Q8NB90;Q8NB90-3;Q8NB90-2 Q8NB90 SPATA5 Spermatogenesis-associated protein 5 0 10929700.0 3174400.0 4560200.0 3195100.0 False True 4161669.1409333292 3879835.935520381 2864501.701563373 1.0 0.9322788054819413 0.6883059668027711 21.988730842492473 -6.947281222040276 0.5879405958355094 1.0028377394281134 0.6055141351921675 0.998970237319362 0.0042954933557369426 0.08459631346678331 0.0406256371481152 0.0044628007225477 0.02042633311754419 1.1290645660633112e-07 6.947281222040276 -0.3973236042359459 TFQNSLIHLGLNTMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 TFQNSLIHLGLNTMK 15 0 Q8NB90;Q8NB90-3;Q8NB90-2 Q8NB90 SPATA5 Spermatogenesis-associated protein 5 0 36914300.0 7901800.0 14545400.0 14467100.0 False True 11987608.298959695 11949659.726271095 11607671.343844805 1.0 0.996834349960209 0.9683058583797852 23.51504051317059 -6.927954142015945 0.763440234848808 1.0004683220085662 0.962743740206379 0.9961199240699579 0.0008878243921525711 0.09371353665674037 0.0829981168061 0.0007992232294579525 0.002610964191181836 1.1804452745429393e-07 6.927954142015945 -0.037724581802187185 TFQNSLIHLGLNTMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFQNSLIHLGLNTMK 15 0 Q8NB90;Q8NB90-3;Q8NB90-2 Q8NB90 SPATA5 Spermatogenesis-associated protein 5 0 25778100.0 3174400.0 9446700.0 13157000.0 False True 4348061.464934419 9029313.557940586 10049587.576920709 1.0 2.0766296959596393 2.311280017075905 22.051940904015364 -10.56512347070427 0.3150668728583034 3.840700600931076e-17 2.374769169228322 0.9991147719071589 0.016986749521112156 2.1445065799857534 0.1530116068421334 1.7676827308355554 0.07912799239923071 2.7219273492109584e-11 10.56512347070427 2.374769169228322 TFQNSLIHLGLNTMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFQNSLIHLGLNTMK 15 0 Q8NB90;Q8NB90-3;Q8NB90-2 Q8NB90 SPATA5 Spermatogenesis-associated protein 5 0 14768600.0 6578900.0 3802700.0 4387000.0 False True 5470646.844686803 3782214.1003231495 5304301.416803807 1.0 0.6913650629808993 0.9695930970129146 22.383279995477167 -10.327784168489648 7.788223430355172 1.0000009859529115 0.8304790803847838 0.33109264537867567 0.11358611925269176 1.944574154068943e-06 1.6781406423839572e-07 0.1099799269840166 0.036659762352167065 4.7012769011368425e-11 10.327784168489648 -0.16952190556812774 TFQNSLIHLGLNTMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TFQNSLIHLGLNTMK 15 0 Q8NB90;Q8NB90-3;Q8NB90-2 Q8NB90 SPATA5 Spermatogenesis-associated protein 5 0 35248100.0 7901800.0 15523800.0 11822500.0 False True 10229035.867764313 14659886.88348306 9670926.30909398 1.0 1.4331640902425702 0.9454386937454043 23.28616683526304 -6.672427391637324 1.929072606945018 1.2759176727939647 0.9474029326480283 0.289665506753886 0.1838982374270051 0.4555968238214887 3.2709826301970577 0.07668823362337511 0.20422271484561264 2.1260457625772866e-07 6.672427391637324 -0.3285147401459364 TFSATVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFSATVR 7 0 Q9Y2V2;H3BSW7;H3BUY4;H3BPY5;H3BNU9;H3BTK3;I3L3X8 Q9Y2V2 CARHSP1 Calcium-regulated heat stable protein 1 0 5100600.0 1860400.0 1714100.0 1526100.0 False True 2439002.4161392273 1458362.961509468 1368193.81138489 1.0 0.5979342012370599 0.5609645166119378 21.217859756630208 -13.999999999999998 0.3376825653697136 5.585127858410394 0.5549917526465034 0.9997305570673557 0.0032636206943439687 19.49308255397849 0.1862599987560762 63.726733662532126 0.01151757050286449 1.0000000000000041e-14 13.999999999999998 -5.030136105763891 TFSATVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFSATVR 7 0 Q9Y2V2;H3BSW7;H3BUY4;H3BPY5;H3BNU9;H3BTK3;I3L3X8 Q9Y2V2 CARHSP1 Calcium-regulated heat stable protein 1 0 2571590.0 854800.0 926630.0 790160.0 False True 827664.8418938641 1296638.1913116144 583193.391708112 1.0 1.5666222916327395 0.7046250634177572 19.65868714937644 -6.729361410650315 1.7252937801373294 1.3412230258644684 0.7051703406312178 0.5564495252992189 0.23820631587808086 0.33742141411165594 1.9673332658625886 0.10942000072154912 0.27174227569253573 1.8648271753430708e-07 6.729361410650315 -0.6360526852332506 TFSATVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFSATVR 7 0 Q9Y2V2;H3BSW7;H3BUY4;H3BPY5;H3BNU9;H3BTK3;I3L3X8 Q9Y2V2 CARHSP1 Calcium-regulated heat stable protein 1 0 11529600.0 3138000.0 5981900.0 2409700.0 False True 4760575.418529384 4914383.208201979 1933421.7387909698 1.0 1.0323086551835596 0.40613194179543827 22.18270453430398 -6.89473913589986 0.9939418750748722 1.0299234155806647 0.34699947514919083 0.9837617668520705 0.03668303450424205 0.11538154536922456 0.20006787109433766 0.027931433296558762 0.07093165171680567 1.2742682554371976e-07 6.89473913589986 -0.6829239404314739 down TFSATVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFSATVR 7 0 Q9Y2V2;H3BSW7;H3BUY4;H3BPY5;H3BNU9;H3BTK3;I3L3X8 Q9Y2V2 CARHSP1 Calcium-regulated heat stable protein 1 0 5015300.0 1860400.0 1322900.0 1832000.0 False True 2548240.1554196035 1264449.9037547086 1399319.3312243458 1.0 0.49620515596439113 0.5491316539566611 21.2810698181531 -10.834845296863467 11.087317123409205 1.00704202582792 0.5226684049605261 0.9908634745502056 0.021607152325583284 0.0036971881580549594 5.50725553250749e-05 0.020565103916921863 0.0069736784263292415 1.462698119801479e-11 10.834845296863467 -0.4843736208673939 TFSATVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFSATVR 7 0 Q9Y2V2;H3BSW7;H3BUY4;H3BPY5;H3BNU9;H3BTK3;I3L3X8 Q9Y2V2 CARHSP1 Calcium-regulated heat stable protein 1 0 9770700.0 3138000.0 2989100.0 3643600.0 False True 4062202.859227566 2822753.957369924 2980502.18649311 1.0 0.6948825686924643 0.7337157423644414 21.95383085639643 -10.469376562380496 9.222476775008829 1.0000036496329627 0.7142991556234004 0.9863331734398524 0.015853576764870914 1.1896772029493006e-06 6.845506934747459e-08 0.015350355632531228 0.005116719899013828 3.393309223791275e-11 10.469376562380496 -0.2857044940095623 TFSFAIPLIEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFSFAIPLIEK 11 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 33996100.0 7779100.0 15546000.0 10671000.0 False True 10198475.432911567 13226597.397833388 9566867.283459907 1.0 1.2969190821551375 0.9380683756502082 23.28185016447007 -6.6869668463058956 1.8769997419551048 1.1866741279125719 0.939345555580057 0.35634280265657103 0.12565401816000102 0.4232275479117213 2.8884684811329353 0.05359982029216681 0.14012365073680894 2.056047547021956e-07 6.6869668463058956 -0.24732857233251493 TFSFAIPLIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFSFAIPLIEK 11 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 30441200.0 11968000.0 8519000.0 9954200.0 False True 11588082.390951995 11920681.125998117 7346896.400401047 1.0 1.0287017923954196 0.6340045015677075 23.46613851149163 -6.8894139307485895 1.0258702653756413 1.021506561528597 0.6004474822358146 0.980519547411591 0.025078294555712404 0.11961886183100551 0.22464880594928882 0.01864104105851996 0.046374284307374135 1.2899891849143422e-07 6.8894139307485895 -0.4210590792927824 TFSFAIPLIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFSFAIPLIEK 11 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 29374000.0 5626000.0 12295000.0 11453000.0 False True 8535053.315693554 10100861.188726533 9189309.529971782 1.0 1.1834561326235538 1.0766551994555484 23.024968734650585 -10.788487210441216 5.676780503184197 0.9918074783529528 1.130055666039551 0.6641121798396684 0.04360129838578346 0.0047520054608335026 0.00017705617541851493 0.04437528334097671 0.014072258543429975 1.627469242355395e-11 10.788487210441216 0.1382481876865983 TFSFAIPLIEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFSFAIPLIEK 11 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 46564100.0 7779100.0 15936000.0 22849000.0 False True 10655243.492272982 15231894.82669515 17452536.789926358 1.0 1.4295210463975867 1.6379294196873744 23.345060225992963 -11.08331360471674 0.133366501374125 5.929637758737843e-21 1.9760882435208877 0.9997354867508754 0.004319630890807718 3.4275033583868924 0.08031486533356479 1.2752924725287087 0.232927276871563 8.254416816057741e-12 11.08331360471674 1.9760882435208877 TFSFAIPLIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFSFAIPLIEK 11 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 24075000.0 11968000.0 6016500.0 6090500.0 False True 9951922.272296535 5984087.920318254 7363995.390709723 1.0 0.6012997043773483 0.739957084593506 23.246543786925905 -10.813292731901651 7.8198027867479025 1.011420158759618 0.6706283944854271 0.8826785294386893 0.05660663843344424 0.011188489066554811 0.00026713839861909963 0.05441106476274537 0.01826971399479286 1.5371182117119584e-11 10.813292731901651 -0.340791764274191 TFSFAIPLIEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFSFAIPLIEK 11 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 17150800.0 5626000.0 5245600.0 6279200.0 False True 7282967.9050396215 4953677.748747005 5136450.030032804 1.0 0.6801729478059612 0.7052687993418887 22.796095056743034 -10.748584087684964 6.890405316927856 1.0056908287232869 0.6927208735739654 0.9950222629275076 0.010245338487277324 0.0009048888909374035 3.3017383690666545e-05 0.010022100407636294 0.0033066687781235873 1.7840865219596628e-11 10.748584087684964 -0.31296995514932147 TFSFAIPLIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFSFAIPLIER 11 0 A0A087WVC1;Q9BQ39 A0A087WVC1 DDX50 ATP-dependent RNA helicase DDX50 0 2884460.0 1007300.0 1043200.0 833960.0 False True 1320580.0547070748 887558.6263617511 747669.8191091953 1.0 0.6720975553114994 0.5661677354918404 20.332740330903498 -13.999999999999998 0.15804416252597092 2.6083783007366486 0.45975312504341054 0.9995416494496328 0.0039537762943728134 11.997202679681441 0.12556181552115345 5.916157028526817 0.09675476275268632 1.0000000000000041e-14 13.999999999999998 -2.148625175693238 TFSFAIPLIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFSFAIPLIER 11 0 A0A087WVC1;Q9BQ39 A0A087WVC1 DDX50 ATP-dependent RNA helicase DDX50 0 4015200.0 1007300.0 1150900.0 1857000.0 False True 1379726.0312589577 1100049.432482647 1418414.8461155072 1.0 0.7972955554653742 1.0280409399982453 20.39595039242639 -6.674679887014521 1.9206091223050632 0.8711396022120189 1.0271333189229008 0.2999966300096675 0.08601259178025394 0.450471767446859 3.2077950758314158 0.035995610998835005 0.09559428783963511 2.1150474402215916e-07 6.674679887014521 0.1559937167108819 TFSFYLSNIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFSFYLSNIGR 11 0 P55199 P55199 ELL RNA polymerase II elongation factor ELL 0 6331200.0 4422300.0 1908900.0 0.0 False True 4281916.5071446365 2671133.724781991 0.0 1.0 0.623817330469906 0.0 22.0298252342903 -7.594241677465107 0.6800952592778449 0.9962405332759705 5.7940899982042515e-21 0.9871157112753569 0.046811066982456725 0.1211369100125799 0.14632286930847443 0.04228466550538093 0.0770487815018669 2.5454133792972317e-08 7.594241677465107 -0.9962405332759705 down TFSFYLSNIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFSFYLSNIGR 11 0 P55199 P55199 ELL RNA polymerase II elongation factor ELL 0 30144300.0 9514100.0 11034000.0 9596200.0 False True 14433585.273878416 9064896.49096451 7699506.863836117 1.0 0.6280419118990456 0.5334438199336734 23.78292637113541 -13.999999999999998 0.1922501175642478 3.0096640889273862 0.467093519820174 0.9994883272672324 0.004555193794587656 12.388241072856296 0.13904694254270095 9.33352950881357 0.06391111169949128 1.0000000000000041e-14 13.999999999999998 -2.5425705691072125 TFSFYLSNIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFSFYLSNIGR 11 0 P55199 P55199 ELL RNA polymerase II elongation factor ELL 0 30502400.0 9514100.0 9668300.0 11320000.0 False True 12316190.000948705 9130250.605881259 9259876.153008563 1.0 0.7413210258349346 0.7518458348154164 23.55405269322786 -9.94509694838543 5.448920183856795 1.0000004526395168 0.7465834303275347 0.998708010422211 0.004296735276347076 5890055.699733573 0.9723714521488499 33.44802631252451 0.00147088677115166 1.1347574733214749e-10 9.94509694838543 -0.25341702231198204 TFSHELSDFGLESTAGEIPVVAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFSHELSDFGLESTAGEIPVVAIR 24 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 148206000.0 28425000.0 97325000.0 22456000.0 False True 43122803.14585654 79956593.34630434 18017561.757185563 1.0 1.8541603864633505 0.4178198178871585 25.361947626002856 -6.745615538676277 1.666256220279746 1.5048811190270583 0.4159130677965347 0.6298728769646749 0.35887003883297447 0.30772460522249395 1.6795659727399082 0.1702479992865435 0.41520682145211707 1.796323127045547e-07 6.745615538676277 -1.0889680512305238 TFSHELSDFGLESTAGEIPVVAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFSHELSDFGLESTAGEIPVVAIR 24 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 6759400.0 2000400.0 2290100.0 2468900.0 False True 2740001.938777349 2188915.8096520198 1885796.6685915862 1.0 0.7988738178151669 0.6882464723485091 21.385745483336063 -13.999999999982242 0.07191903651512926 2.146418142140133 0.3021449721050655 0.9999177568938269 0.0011702958183472077 12.340431089371029 0.07302117487572075 2.34661297714684 0.354576213818613 1.0000000000408898e-14 13.999999999982242 -1.8442731700350676 TFSHELSDFGLESTAGEIPVVAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFSHELSDFGLESTAGEIPVVAIR 24 0 P30101 P30101 PDIA3 Protein disulfide-isomerase A3 0 64218000.0 28425000.0 21435000.0 14358000.0 False True 36796722.8405174 20242123.40712067 11744991.325520927 1.0 0.5501066900672953 0.31918579750771575 25.133073948095305 -9.994763351835509 0.15634587573136186 1.6957538406622703 7.693308737732789e-12 0.9997039118728678 0.004864349526011463 1.5438948826115104 0.07185028338265292 0.6325522907447892 0.18895664605382617 1.0121308166754765e-10 9.994763351835509 -1.695753840654577 TFSVWYVPEVTGTHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFSVWYVPEVTGTHK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98 P21333-2 FLNA Filamin-A 0 43216000.0 13191000.0 15915000.0 14110000.0 False True 17293528.741825707 13540544.036184113 12650032.552677272 1.0 0.7829832903585076 0.7314893762591212 24.043728944926762 -13.999999999651628 0.20207682409634503 2.2160139218454593 0.6987229748791473 0.9994871346353357 0.0026350249092974183 12.572724798823732 0.14252919715124698 6.048136772848209 0.03228803914087709 1.0000000008021562e-14 13.999999999651628 -1.517290946966312 TFSVWYVPEVTGTHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFSVWYVPEVTGTHK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98 P21333-2 FLNA Filamin-A 0 43371000.0 16713000.0 10348000.0 16310000.0 False True 16182454.96323366 14480010.364107125 12037921.710488131 1.0 0.8947968894092726 0.7438872370006987 23.947927152981723 -6.965989793914078 0.34065114321926676 1.0162453529995588 0.6174187864518037 0.999932102570284 0.0008660954624007942 0.07762681147416 0.013685322923938495 0.0021260832133549235 0.013055652504246456 1.0814593657067692e-07 6.965989793914078 -0.39882656654775506 TFSVWYVPEVTGTHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFSVWYVPEVTGTHK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98 P21333-2 FLNA Filamin-A 0 50363000.0 16003000.0 19022000.0 15338000.0 False True 24277720.97601203 15627375.480435653 12306437.57711579 1.0 0.6436920292426344 0.5069025049458041 24.533129661961432 -13.999999999999998 0.13259904682131265 2.694290816391985 0.321514287372212 0.9996340125460735 0.003976318390016511 11.933597417177054 0.11348843331019272 5.2579567642740495 0.16504769420118792 1.0000000000000041e-14 13.999999999999998 -2.3727765290197733 TFSVWYVPEVTGTHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFSVWYVPEVTGTHK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98 P21333-2 FLNA Filamin-A 0 42469000.0 13191000.0 11203000.0 18075000.0 False True 18068069.17337131 10708014.416633159 13806057.266310073 1.0 0.5926485178845016 0.7641135936460447 24.106939006449654 -10.183520864315717 5.365873014504603 1.0000133726741052 0.6783810557652012 0.8242856890926217 0.07000032405415897 1.1198974906588541e-05 1.704095887040077e-06 0.06778033831437814 0.02259250744087022 6.553588004198973e-11 10.183520864315717 -0.3216323169089039 TFSVWYVPEVTGTHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFSVWYVPEVTGTHK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98 P21333-2 FLNA Filamin-A 0 34732500.0 16713000.0 8904500.0 9115000.0 False True 13897600.01143815 8856529.691095147 11020904.357001765 1.0 0.6372704412132996 0.7930077385973998 23.728332428416 -10.175509136998732 5.320468828123564 1.000011693779922 0.7151390909855049 0.8168788622576862 0.0635794854188308 8.819395115500915e-06 1.3668390018978006e-06 0.06156309806055772 0.02052019068225271 6.675608561925806e-11 10.175509136998732 -0.28487260279441706 TFSVWYVPEVTGTHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFSVWYVPEVTGTHK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98 P21333-2 FLNA Filamin-A 0 49653000.0 16003000.0 18178000.0 15472000.0 False True 20716198.96629023 17166378.32025377 12656254.756126182 1.0 0.8286451751205521 0.6109351805666988 24.30425598405388 -6.967869481843072 0.3048133181746732 1.0356621206058545 0.39704943294521955 0.9999606675938575 0.00099848011428968 0.07700028180040308 0.011491762409000997 0.0035284290643055635 0.019428189892950073 1.0767887714357975e-07 6.967869481843072 -0.638612687660635 TFSWASVTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFSWASVTSK 10 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 63883000.0 19113000.0 17013000.0 27757000.0 False True 25057328.090555284 14474726.7161546 24884971.90394497 1.0 0.5776644127356291 0.9931215257274266 24.578729249820316 -10.874891833986206 10.409790959920432 1.0106977905390793 0.7853929692315281 0.2624139525831988 0.16960965613995332 0.04148679706858896 0.0004986006026470409 0.16179211544437028 0.05474128113216718 1.3338536023097375e-11 10.874891833986206 -0.22530482130755114 TFSWASVTSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFSWASVTSK 10 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 49718000.0 20146000.0 10701000.0 18871000.0 False True 19506476.25736289 14973965.104977798 13928118.982134992 1.0 0.7676407008326654 0.7140253728234335 24.217449850401895 -13.999999999999998 0.2060305504045587 2.3223772288978264 0.6812034745945198 0.9994881687553432 0.002807995198373219 12.656671937799036 0.14389506892541865 6.7625300087224085 0.032665861025718515 1.0000000000000041e-14 13.999999999999998 -1.6411737543033067 TFSWASVTSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFSWASVTSK 10 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 106943000.0 38475000.0 39463000.0 29005000.0 False True 58369387.89927285 32420519.324173708 23272149.03665691 1.0 0.5554370277125622 0.39870469563287686 25.79870860343882 -13.999999999999998 0.14528702998976972 3.1355892216182246 0.21656179929305144 0.9995827226614281 0.0052024395347976095 11.943112954041732 0.1197803302525175 7.212386215575058 0.16348030250154566 1.0000000000000041e-14 13.999999999999998 -2.9190274223251733 TFSWASVTSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFSWASVTSK 10 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 52921000.0 19113000.0 16999000.0 16809000.0 False True 26179592.609403826 16247927.971824257 12839060.39222163 1.0 0.620633338885034 0.49042246698712116 24.641939311343208 -13.999999999999998 0.14922183245989618 2.8322333200762366 0.34587501251607955 0.9995688577286463 0.004488425227842779 11.954872347233533 0.12161754278883102 6.352692765980151 0.1301899278270275 1.0000000000000041e-14 13.999999999999998 -2.486358307560157 TFSWASVTSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFSWASVTSK 10 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 44710400.0 20146000.0 15911000.0 8653400.0 False True 16752291.619124845 15825284.28491376 10462785.931199022 1.0 0.9446638492638948 0.6245584884192463 23.99785512583617 -6.936613186593938 0.6903532066971151 1.0038890322579797 0.54620825245219 0.9976857687850251 0.007961190394703981 0.08934634083477912 0.06190405218250747 0.00756351129158026 0.02798656721129178 1.1571424162924728e-07 6.936613186593938 -0.4576807798057897 TFSWASVTSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFSWASVTSK 10 0 Q13283 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 128769000.0 38475000.0 66221000.0 24073000.0 False True 49806645.95563439 62535743.137062624 19691961.00983882 1.0 1.2555702544750105 0.39536814077742893 25.569834925531268 -6.827086620667248 1.3408010023911225 1.1368564840690782 0.3735541041387659 0.8999493158500491 0.1140875368572031 0.18442279141000728 0.6494215154570229 0.06682719648047201 0.15382505355142254 1.4890640520958238e-07 6.827086620667248 -0.7633023799303124 down TFSYAGFEMQPK ddPTM_RPMI8226_Bortezomib_1h_R1 2 TFSYAGFEMQPK 12 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 109522700.0 34546900.0 39128800.0 35847000.0 False True 45291320.45265553 33290935.562867835 32137896.308704607 1.0 0.7350400745694292 0.7095817915553904 25.43273126548359 -13.999999999998712 0.3312830222288789 3.9066643515539115 0.7051405891716129 0.9997174974151634 0.002207124372668822 18.932700943606985 0.1841276966724595 38.36846215697878 0.008119530505515699 1.0000000000029653e-14 13.999999999998712 -3.2015237623822985 TFSYAGFEMQPK ddPTM_RPMI8226_Bortezomib_2h_R1 2 TFSYAGFEMQPK 12 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 103752440.0 32281440.0 21331700.0 50139300.0 False True 31256683.35716691 29849559.053345904 37006313.18324206 1.0 0.954981650236465 1.1839488137744725 24.89766136647677 -6.855662038348862 1.2074836075324382 0.975804521821252 1.1941507476042812 0.9481408383186166 0.022555200645255492 0.15134043062774782 0.42178914780015114 0.014592651500629805 0.03391354602167679 1.3942413592509792e-07 6.855662038348862 0.2183462257830292 TFSYAGFEMQPK ddPTM_RPMI8226_Bortezomib_8h_R1 2 TFSYAGFEMQPK 12 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 185547100.0 48667500.0 89496000.0 47383600.0 False True 73832155.57083455 73524739.56456049 38018210.691030316 1.0 0.9958362856414354 0.5149275460954903 26.137745943627536 -6.908796313543459 0.9038936469070393 1.0154626479244833 0.45435230121032605 0.9904593250525486 0.022239962821319598 0.10521935491415449 0.14312501134079253 0.01810047598454194 0.04955840917329119 1.2336833016943923e-07 6.908796313543459 -0.5611103467141572 TFSYAGFEMQPK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TFSYAGFEMQPK 12 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 101169130.0 34546900.0 29025830.0 37596400.0 False True 47319822.52486862 27743372.855015896 28716904.64216324 1.0 0.5862949473328127 0.6068683927770705 25.49594132700648 -10.123810191433316 4.91309632499951 1.0000199963484657 0.5965816700531896 0.9980532150892032 0.008399073937626246 2234194.392463886 4603728.302836493 319.67814584894586 0.0028752265943632976 7.51951462882116e-11 10.123810191433316 -0.4034383262952761 TFSYAGFEMQPK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TFSYAGFEMQPK 12 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 87030040.0 32281440.0 36145100.0 18603500.0 False True 26843447.67027109 35950379.17205937 22493405.837134633 1.0 1.3392608734039084 0.8379477224174116 24.678066641911045 -6.724445734150807 1.74339713913969 1.2054198861361187 0.8385320081666493 0.5333404452739785 0.14269040304163155 0.3467674869476545 2.062104186377774 0.06492945304632537 0.16214627813857477 1.8860546205655114e-07 6.724445734150807 -0.3668878779694694 TFSYAGFEMQPK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TFSYAGFEMQPK 12 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 148983900.0 48667500.0 55121500.0 45194900.0 False True 63001038.12984627 52053940.069307305 36969891.93883457 1.0 0.8262394019924434 0.5868140118999144 25.908872265719985 -6.966629721660132 0.3288836453475877 1.0295519441231853 0.3756766039654161 0.9999429038637341 0.00127993931646362 0.07741219884293221 0.012932999981585726 0.003507625348109302 0.020902112100826275 1.0798670216511372e-07 6.966629721660132 -0.6538753401577693 TFSYPLDLLLK(ub)LHDER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFSYPLDLLLKLHDER 16 1 Q9Y296;E9PKS9;E9PQE8;J3KP27;Q9Y296-2;E9PN70;G3V1A0;G5EA23 Q9Y296 TRAPPC4 Trafficking protein particle complex subunit 4 1 9548800.0 4092800.0 2278600.0 3177400.0 True False 3962876.3042854555 3188456.8627420254 2345143.6200432237 1.0 0.8045814751507705 0.5917781530317221 21.918116505598267 -6.970034215891611 0.2573772393717905 1.061690687804576 0.32837697269865396 0.9999826441717912 0.000694479638663557 0.07629167735820319 0.008990874468736929 0.004518716699910314 0.020158330737951514 1.0714348889124487e-07 6.970034215891611 -0.733313715105922 TFSYPLDLLLK(ub)LHDER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFSYPLDLLLKLHDER 16 1 Q9Y296;E9PKS9;E9PQE8;J3KP27;Q9Y296-2;E9PN70;G3V1A0;G5EA23 Q9Y296 TRAPPC4 Trafficking protein particle complex subunit 4 1 36384900.0 5824600.0 8701300.0 21859000.0 True False 8836344.035298366 7148485.031432804 17538559.06885993 1.0 0.8089867260573936 1.9848207583135062 23.07501815917586 -6.8652509792688745 1.1589908578065358 0.8945344822948712 2.0477240683723625 0.9597054858205698 0.10342003041846713 0.14148586246390213 0.3582139218647298 0.06943592972274182 0.1631593066394259 1.363794770282471e-07 6.8652509792688745 1.1531895860774912 TFSYPLDLLLK(ub)LHDER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFSYPLDLLLKLHDER 16 1 Q9Y296;E9PKS9;E9PQE8;J3KP27;Q9Y296-2;E9PN70;G3V1A0;G5EA23 Q9Y296 TRAPPC4 Trafficking protein particle complex subunit 4 1 8514200.0 4092800.0 2909000.0 1512400.0 True False 3403344.5417826925 2893328.6396087105 1828635.8474524904 1.0 0.8501427357963491 0.5373055313684578 21.698521781032543 -6.959198090185123 0.4465922089220816 1.0104472266062006 0.3646695043617956 0.9997392897562631 0.0031124113509790738 0.0799888334190775 0.022199238275261088 0.004160795403207915 0.025890497258708293 1.0985046757344412e-07 6.959198090185123 -0.645777722244405 TFSYPLDLLLK(ub)LHDER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFSYPLDLLLKLHDER 16 1 Q9Y296;E9PKS9;E9PQE8;J3KP27;Q9Y296-2;E9PN70;G3V1A0;G5EA23 Q9Y296 TRAPPC4 Trafficking protein particle complex subunit 4 1 37991300.0 5824600.0 7087700.0 25079000.0 True False 7540059.520030879 6693263.264410964 20514879.3322705 1.0 0.8876936908295855 2.7207847998773467 22.846144481268308 -6.892320124463819 1.0085365065885765 0.9069142356905193 2.885817633447068 0.9823429182703161 0.11147437482653223 0.11728165273088685 0.2110035723041118 0.08395048475968274 0.21112017599935862 1.2813857073470336e-07 6.892320124463819 1.9789033977565487 up TFTAWCNSHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFTAWCNSHLR 11 0 A0A494C1A0;P35609-2;P35609;A0A494C166;A0A494C033;K7EP19;A0A494C0Q3;O43707;O43707-3;F5GXS2;P12814-2;P12814;P12814-3;P12814-4;Q08043;G3V2N5 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1;ACTN3 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-3 0 43396000.0 11919000.0 13191000.0 18286000.0 False True 15625924.423760181 11222954.218115274 16393940.13169783 1.0 0.7182265774337216 1.0491500974348649 23.897438205802214 -6.681194953621195 1.8978653567351607 0.8219048337261325 1.0478945678432332 0.32945456913583626 0.1193921367290076 0.4359020976410116 3.0366668194465194 0.05046201064075923 0.13287588371072953 2.0835553707540394e-07 6.681194953621195 0.22598973411710066 TFTAWCNSHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFTAWCNSHLR 11 0 A0A494C1A0;P35609-2;P35609;A0A494C166;A0A494C033;K7EP19;A0A494C0Q3;O43707;O43707-3;F5GXS2;P12814-2;P12814;P12814-3;P12814-4;Q08043;G3V2N5 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1;ACTN3 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-3 0 35404700.0 11405000.0 16075000.0 7924700.0 False True 17302218.817185365 13206290.65545173 6358379.571480596 1.0 0.7632715084110848 0.36748925895938617 24.044453723535383 -6.963391822722805 0.3846555077727965 1.0258027462977 0.09085811416297586 0.9998760602100593 0.002904867140667814 0.07851100455476699 0.016810938907850043 0.00512873882430675 0.03337069982162407 1.0879480980308903e-07 6.963391822722805 -0.9349446321347241 down TFTAWCNSHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFTAWCNSHLR 11 0 A0A494C1A0;P35609-2;P35609;A0A494C166;A0A494C033;K7EP19;A0A494C0Q3;O43707;O43707-3;F5GXS2;P12814-2;P12814;P12814-3;P12814-4;Q08043;G3V2N5 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1;ACTN3 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-3 0 34042000.0 11919000.0 11514000.0 10609000.0 False True 16325776.398863817 11005273.408293685 8103372.6992134685 1.0 0.6741041368825553 0.4963545072060045 23.960648267325105 -12.179295707841769 0.08919475316887998 2.2735982909488297 1.5953418884003968e-20 0.9998952283736121 0.002134733714859613 6.136694288201876 0.06794155936894927 1.8466279164683588 0.37488408100199977 6.617657589437516e-13 12.179295707841769 -2.2735982909488297 TFTAWCNSHLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFTAWCNSHLR 11 0 A0A494C1A0;P35609-2;P35609;A0A494C166;A0A494C033;K7EP19;A0A494C0Q3;O43707;O43707-3;F5GXS2;P12814-2;P12814;P12814-3;P12814-4;Q08043;G3V2N5 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1;ACTN3 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-3 0 11980400.0 5851100.0 2907100.0 3222200.0 False True 4865448.897680003 2891438.875285833 3895947.122230503 1.0 0.5942799803456081 0.8007374456421095 22.21414148688561 -10.274263094643544 4.776139890279276 1.0001033922787672 0.6975087129933987 0.7410816776570783 0.08428590726249563 9.282678752026609e-05 1.4105095174925566e-05 0.08163726563932402 0.027203159595394794 5.31786006871448e-11 10.274263094643544 -0.30259467928536854 TFTAWCNSHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFTAWCNSHLR 11 0 A0A494C1A0;P35609-2;P35609;A0A494C166;A0A494C033;K7EP19;A0A494C0Q3;O43707;O43707-3;F5GXS2;P12814-2;P12814;P12814-3;P12814-4;Q08043;G3V2N5 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1;ACTN3 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1;Alpha-actinin-3 0 37031000.0 11405000.0 13976000.0 11650000.0 False True 14763997.326160112 13198223.314108627 9529819.539094506 1.0 0.8939464714425873 0.6454769212270688 23.815580045627833 -6.956837477989958 0.47792662474960756 1.0060819091369648 0.5230184121942868 0.9996343169534012 0.002841172420984502 0.08085083564780482 0.02545726252437822 0.0034887478318528452 0.020498277800508034 1.1044918663575479e-07 6.956837477989958 -0.48306349694267803 TFTEMDSHEEK(ub)VFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFTEMDSHEEKVFR 14 1 P48444;B0YIW6;P48444-2;Q6P1Q5 P48444 ARCN1 Coatomer subunit delta 1 17985700.0 8900000.0 6982500.0 2103200.0 True False 11667986.187722597 5940738.217571816 1885581.0393189837 1.0 0.5091485473151175 0.16160295435582947 23.47605224773408 -8.171810521731336 0.32954486168367597 1.1156384736526788 2.5752458914248557e-23 0.9986073415615297 0.012835148813122896 0.09280230331030756 0.0755813128200221 0.0708791628746169 0.09019077737125028 6.732703332193791e-09 8.171810521731336 -1.1156384736526788 down TFTEMDSHEEK(ub)VFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFTEMDSHEEKVFR 14 1 P48444;B0YIW6;P48444-2;Q6P1Q5 P48444 ARCN1 Coatomer subunit delta 1 15322000.0 6115300.0 4499600.0 4707100.0 True False 5921173.148845975 6296313.745104019 3474169.300026903 1.0 1.0633557889336773 0.5867366504396196 22.497451611453062 -6.873402379215508 1.1158747451993327 1.0366903117925 0.5569493044753455 0.9679656468054214 0.03782522953789431 0.13363775117779186 0.3089349067245362 0.026247813744218546 0.06254020934490474 1.3384360352139055e-07 6.873402379215508 -0.4797410073171544 TFTEMDSHEEK(ub)VFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFTEMDSHEEKVFR 14 1 P48444;B0YIW6;P48444-2;Q6P1Q5 P48444 ARCN1 Coatomer subunit delta 1 57511000.0 17371000.0 15470000.0 24670000.0 True False 26353076.990208395 12709257.632338325 19793963.68675489 1.0 0.4822684515003886 0.7511063582483908 24.65146808525224 -10.54755838439923 7.7761366646779875 1.0001162249750466 0.6166874048744393 0.7305011123679765 0.10975261584175533 0.00022121563639843658 1.2871089903153228e-05 0.10629927448076266 0.03542250444648486 2.834272582308179e-11 10.54755838439923 -0.3834288201006073 TFTEMDSHEEK(ub)VFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFTEMDSHEEKVFR 14 1 P48444;B0YIW6;P48444-2;Q6P1Q5 P48444 ARCN1 Coatomer subunit delta 1 21113600.0 8900000.0 7995800.0 4217800.0 True False 12190570.513456497 7642519.117425274 3221642.508317715 1.0 0.6269205455962147 0.26427331721362196 23.539262309256973 -7.529962233154811 0.3089525868083908 1.0838211967167526 1.6957941578694296e-13 0.999630226383859 0.005775946709956671 0.12454400647980425 0.03424273211518842 0.0238025388434742 0.06721364691626291 2.9514658790371446e-08 7.529962233154811 -1.083821196716583 down TFTEMDSHEEK(ub)VFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFTEMDSHEEKVFR 14 1 P48444;B0YIW6;P48444-2;Q6P1Q5 P48444 ARCN1 Coatomer subunit delta 1 17963600.0 6115300.0 10257000.0 1591300.0 True False 5085142.903724508 10201743.505144894 1924033.4726601113 1.0 2.0061861973776267 0.37836369775388073 22.27785688688734 -6.739523952348016 1.688601591281999 1.5990227364903256 0.37754676862921516 0.6026946256292687 0.42276205370682124 0.31869924387575677 1.7841473398124346 0.19808228238322279 0.4862998437531721 1.8216965995283618e-07 6.739523952348016 -1.2214759678611105 TFTEMDSHEEK(ub)VFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFTEMDSHEEKVFR 14 1 P48444;B0YIW6;P48444-2;Q6P1Q5 P48444 ARCN1 Coatomer subunit delta 1 58185000.0 17371000.0 16356000.0 24458000.0 True False 22487101.933601674 15445774.221920472 20006894.96027237 1.0 0.6868726022378367 0.8897053528439244 24.42259440734469 -10.639863121915692 6.149878183420118 1.001291057366456 0.7882889775408806 0.592271359805451 0.08280612368501836 0.001474252704452461 8.633210589060713e-05 0.0806387377166875 0.026725561499672302 2.2915897871912456e-11 10.639863121915692 -0.2130020798255754 TFTTQETITNAETAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFTTQETITNAETAK 15 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 78092000.0 11847000.0 33865000.0 32380000.0 False True 15531531.726511186 28812474.00473608 29029628.210892256 1.0 1.8550954607751469 1.8690769669124656 23.888696780174463 -11.090467796327076 0.6867843760907363 1.1658590285128397e-14 1.8667180470386324 0.9999712255659889 0.0021801639213801923 3.2859954587731015 0.34938783120334765 5.126028936304351 0.0022069630600543974 8.11955454578492e-12 11.090467796327076 1.8667180470386207 TFTTQETITNAETAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFTTQETITNAETAK 15 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 58700000.0 18413000.0 13317000.0 26970000.0 False True 17828489.393766608 18634547.547237553 19905747.917343073 1.0 1.0452118031801823 1.1165134340715785 24.08768113293738 -6.964411376044085 0.36801600337890467 0.9943920293763687 1.1698073891952285 0.999900476657048 0.0004784433795502979 0.07816131271506216 0.015567803837537635 0.000942740508662249 0.006062129986581026 1.0853970177090131e-07 6.964411376044085 0.1754153598188598 TFTTQETITNAETAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFTTQETITNAETAK 15 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 131819000.0 23548000.0 90390000.0 17881000.0 False True 35724037.58939774 74259198.27970648 14346812.512479275 1.0 2.0786899603348665 0.4016010921659413 25.090391809648633 -6.733028738487139 1.71222284789901 1.6469571296096803 0.4020450793590363 0.5732156709307779 0.453358201916304 0.3305992785344008 1.9001314276592394 0.2097113649907676 0.5186025618679011 1.8491462517220037e-07 6.733028738487139 -1.244912050250644 TFTTQETITNAETAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFTTQETITNAETAK 15 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 57731000.0 11847000.0 24850000.0 21034000.0 False True 16227156.053136975 23752044.832039103 16066202.408827985 1.0 1.4637219703971136 0.9900812167096973 23.951906841697355 -6.6510423453566 2.005030260373999 1.3006693146912955 0.9920823117792774 0.1981677979990747 0.19787280166681032 0.5060074537309297 3.9004181400044917 0.08000814809761711 0.21915199173082056 2.2333544516974994e-07 6.6510423453566 -0.3085870029120181 TFTTQETITNAETAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFTTQETITNAETAK 15 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 35260800.0 18413000.0 10104000.0 6743800.0 False True 15311225.334207539 10049567.746513033 8153897.400191812 1.0 0.6563529389160523 0.5325437528487548 23.868086408371656 -13.999999999999998 0.14208603960491992 2.64482037184952 0.38310685461092425 0.9995947491606627 0.003980823626606098 11.936743408920467 0.11824810998151437 5.437589853361885 0.13379110480184317 1.0000000000000041e-14 13.999999999999998 -2.2617135172385954 TFTTQETITNAETAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFTTQETITNAETAK 15 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 68027000.0 23548000.0 23120000.0 21359000.0 False True 30483350.2004751 21833351.675886627 17471881.161847167 1.0 0.7162385870417334 0.5731614486905989 24.861518131741082 -13.999999999999998 0.08848725546522215 2.4628324896366416 0.2056983786996772 0.9998494491001688 0.002176468055272111 12.177417426779403 0.08605618838663817 3.368628041863489 0.33062093718416086 1.0000000000000041e-14 13.999999999999998 -2.2571341109369643 TFVEAGK(ub)NNSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFVEAGKNNSK 11 1 Q9P287-4;Q9P287-3;Q9P287;Q9P287-2 Q9P287-4 BCCIP BRCA2 and CDKN1A-interacting protein 1 1852110.0 354940.0 638370.0 858800.0 True False 343672.62398433295 893274.4700555708 633854.5165522506 1.0 2.5992017045160183 1.8443555649086154 18.390675409606313 -10.37008113613535 7.417249259539075 0.9999740147317553 2.221778634712317 0.7774348777549793 0.3081646460579687 0.00013242273511232587 1.1246569132007298e-05 0.29838542118884115 0.09945971183936797 4.264998314416224e-11 10.37008113613535 1.2218046199805617 TFVLEVMGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFVLEVMGR 9 0 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0;P17858;P17858-2;Q01813;Q01813-2;Q5VSR5 A0A2R8Y891;P17858;Q01813 PFKM;PFKL;PFKP ATP-dependent 6-phosphofructokinase, muscle type;ATP-dependent 6-phosphofructokinase, liver type;ATP-dependent 6-phosphofructokinase, platelet type 0 37618500.0 9426500.0 16910000.0 11282000.0 False True 14300689.669460583 13892278.381566962 9052107.754923739 1.0 0.9714411474318059 0.6329840003629126 23.769581388747934 -6.923574828938596 0.797768063897331 1.0065502447641064 0.573650136818619 0.9951176163103713 0.011647295350913404 0.09611390878972063 0.09504847910970396 0.010230221046037142 0.031774806017010576 1.1924087961212857e-07 6.923574828938596 -0.4329001079454874 TFVLEVMGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFVLEVMGR 9 0 A0A2R8Y891;P08237;P08237-3;P08237-2;F8VZI0;P17858;P17858-2;Q01813;Q01813-2;Q5VSR5 A0A2R8Y891;P17858;Q01813 PFKM;PFKL;PFKP ATP-dependent 6-phosphofructokinase, muscle type;ATP-dependent 6-phosphofructokinase, liver type;ATP-dependent 6-phosphofructokinase, platelet type 0 30696300.0 9426500.0 13608000.0 7661800.0 False True 12202790.074094553 12850702.83760663 6267431.016706798 1.0 1.053095460921477 0.5136063948204764 23.540707710840383 -6.882712383347782 1.064584626022901 1.0342509025344613 0.4733318961207727 0.9758071036627505 0.03776099182011861 0.12525329812665684 0.25801256600264516 0.02725391850636548 0.06638384387927025 1.310049231357974e-07 6.882712383347782 -0.5609190064136886 TFVLKPGMVLFLGAIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFVLKPGMVLFLGAIGR 17 1 Q8NC60 Q8NC60 NOA1 Nitric oxide-associated protein 1 0 10155900.0 3207600.0 2404100.0 4544200.0 False True 4866163.706970961 1975069.571680968 3646036.8782063876 1.0 0.40587816000756555 0.7492630946598249 22.214353425412757 -10.26672724440403 5.903531940195278 1.0000198086543897 0.577570627333731 0.6686360234290459 0.14018631254283737 3.655049014895301e-05 4.54000163153954e-06 0.13574116677590636 0.04524493782038536 5.4109404656557944e-11 10.26672724440403 -0.4224491813206587 TFVNITPAEVGVLVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFVNITPAEVGVLVGK 16 0 P07737;I3L3D5 P07737 PFN1 Profilin-1 0 146172250.0 43852350.0 71168000.0 31151900.0 False True 57490855.51676152 60550011.8106912 27928600.218125273 1.0 1.0532111805683215 0.48579204409269333 25.77682916375067 -6.883933614374652 1.057579206285777 1.0350672753511927 0.44241208390169257 0.9767238769101666 0.03903620080464838 0.12420440170257453 0.25169384515774257 0.028324234336234894 0.0692361122111635 1.3063705627821708e-07 6.883933614374652 -0.5926551914495002 down TFVNITPAEVGVLVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFVNITPAEVGVLVGK 16 0 P07737;I3L3D5 P07737 PFN1 Profilin-1 0 461241000.0 164180400.0 149020000.0 148040600.0 False True 158968583.06980735 208524463.1290337 109264325.73719735 1.0 1.311733797347021 0.6873328278281028 27.24416643323819 -6.770973064422739 1.5708676090264417 1.1785796665362391 0.6837021260807095 0.7342292089849255 0.13141402869986515 0.26485376852457504 1.289980171526174 0.06593713171475987 0.15680914643354132 1.6944428890080358e-07 6.770973064422739 -0.4948775404555297 TFVNITPAEVGVLVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFVNITPAEVGVLVGK 16 0 P07737;I3L3D5 P07737 PFN1 Profilin-1 0 1052770000.0 256080000.0 532070000.0 264620000.0 False True 388492081.9557065 437117951.4181151 212317741.01293406 1.0 1.1251656641690644 0.5465175504841853 28.53330995376883 -6.850076985228014 1.234650965217647 1.0668011603264285 0.5233433341818294 0.9404199895560938 0.06067693038684803 0.15737916130795748 0.46160481309451884 0.038453908804640356 0.08899269842772774 1.4122871732923533e-07 6.850076985228014 -0.543457826144599 TFVNITPAEVGVLVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFVNITPAEVGVLVGK 16 0 P07737;I3L3D5 P07737 PFN1 Profilin-1 0 247200540.0 43852350.0 54220690.0 149127500.0 False True 60065748.860199384 51825040.631955475 113906655.87727012 1.0 0.8628052028881913 1.8963661993523677 25.84003922527356 -6.87345540962467 1.115613082644149 0.920518395884916 1.9610196315041029 0.968013801765129 0.0819697006142399 0.133587000551763 0.3086428651741945 0.05689279352211781 0.13556927611100936 1.3382726127430404e-07 6.87345540962467 1.0405012356191867 TFVNITPAEVGVLVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFVNITPAEVGVLVGK 16 0 P07737;I3L3D5 P07737 PFN1 Profilin-1 0 352713300.0 164180400.0 93582000.0 94950900.0 False True 136523277.02494597 93077855.19142738 114804694.18664159 1.0 0.6817727879064893 0.8409166311299728 27.024571708672465 -10.184222877770765 4.9236216071265835 1.0000229716845614 0.7613447095177351 0.749904974916992 0.06497020193555189 1.6384600475437705e-05 2.7146669195559602e-06 0.06291317774348666 0.02096904250776556 6.543003042253729e-11 10.184222877770765 -0.2386782621668263 TFVNITPAEVGVLVGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFVNITPAEVGVLVGK 16 0 P07737;I3L3D5 P07737 PFN1 Profilin-1 0 726981200.0 256080000.0 255070000.0 215831200.0 False True 331500608.09145856 240875130.2754498 176552136.21512583 1.0 0.726620477899679 0.5325846526544422 28.304436275861278 -7.659818092804249 0.12318462209916217 1.387631441951613 1.1834784625999922e-08 0.999989500638529 0.0006212491125178172 0.13676182798647518 0.013817320213374297 0.06055717317798677 0.08596961984664474 2.1886781747148528e-08 7.659818092804249 -1.3876314301168282 TFVNITPAEVGVLVGK(ub)DR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFVNITPAEVGVLVGKDR 18 1 P07737;I3L3D5 P07737 PFN1 Profilin-1 1 20968400.0 7679000.0 10878000.0 2411400.0 True False 10067243.363541793 9255044.802111885 2161891.459782137 1.0 0.9193226455246667 0.21474512751041258 23.263165359453758 -6.92850223092246 0.7589881486784619 1.01133118603449 0.07546685865419762 0.9962355385557555 0.02163986404025933 0.0934231454885372 0.08154588636216759 0.019542055089195032 0.06428525458838041 1.1789564670599598e-07 6.92850223092246 -0.9358643273802923 down TFVNITPAEVGVLVGK(ub)DR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFVNITPAEVGVLVGKDR 18 1 P07737;I3L3D5 P07737 PFN1 Profilin-1 1 105276000.0 59592000.0 33311000.0 12373000.0 True False 57700284.57901159 46612256.0145701 9132140.11795646 1.0 0.8078340749037701 0.15826854554679726 25.782075098501988 -7.060261538609314 0.6273612546872049 1.0031872649266234 3.4245277359695346e-22 0.9987118697589358 0.01292598885302601 0.07534200050888804 0.04594327286316141 0.013137991693005266 0.0474066787971633 8.704392406035399e-08 7.060261538609314 -1.0031872649266234 down TFVNITPAEVGVLVGK(ub)DR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFVNITPAEVGVLVGKDR 18 1 P07737;I3L3D5 P07737 PFN1 Profilin-1 1 86452000.0 36106000.0 19749000.0 30597000.0 True False 54775441.70217401 16224636.650358716 24549489.538858518 1.0 0.2962027533903897 0.4481842368764351 25.7070258771827 -10.15064856995498 7.845196791565052 1.0000001363002762 0.37219349514289085 0.9578972995425077 0.062046180815339864 1.4789730343596167e-07 1.608926693964932e-08 0.06007596878085018 0.02002531874946546 7.068893360316397e-11 10.15064856995498 -0.6278066411573853 TFVNITPAEVGVLVGK(ub)DR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFVNITPAEVGVLVGKDR 18 1 P07737;I3L3D5 P07737 PFN1 Profilin-1 1 34348700.0 7679000.0 20971000.0 5698700.0 True False 10518133.817172201 20044431.878176715 4352784.4284105785 1.0 1.9057023067582208 0.4138361903424446 23.32637542097665 -6.742370451430076 1.67809376624485 1.5374000377662842 0.4125122789356251 0.6155314193077173 0.3805223260934601 0.3135306061900668 1.7344766595344754 0.17932718728814748 0.4389000112154481 1.809795685653684e-07 6.742370451430076 -1.1248877588306592 TFVNITPAEVGVLVGK(ub)DR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFVNITPAEVGVLVGKDR 18 1 P07737;I3L3D5 P07737 PFN1 Profilin-1 1 101447200.0 59592000.0 33682000.0 8173200.0 True False 49553388.3732198 33500548.380646445 9882178.331392959 1.0 0.6760495998443405 0.19942487599361816 25.562480373936264 -7.3157888620719325 0.4366426809851867 1.0228296513404789 7.431700815906108e-25 0.999162841070699 0.009513645597208879 0.10300146590440823 0.03890223651442211 0.01297367133283414 0.05479771484170347 4.832937044740557e-08 7.3157888620719325 -1.0228296513404789 down TFVNITPAEVGVLVGK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFVNITPAEVGVLVGKDR 18 1 P07737;I3L3D5 P07737 PFN1 Profilin-1 1 93476000.0 36106000.0 24223000.0 33147000.0 True False 46739928.75566303 22874968.756271712 27114586.11694125 1.0 0.48940957689200953 0.5801161199599825 25.47815219927515 -10.439071759354851 6.710791686952364 1.0000800567310595 0.5347628484260776 0.9722807536430086 0.037030791141386715 4.436233835220315e-05 3.708065566488152e-06 0.03586102377250784 0.011951636448956323 3.6385491067786325e-11 10.439071759354851 -0.4653172083049819 TFVPNSTECGGDK(ub)GR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFVPNSTECGGDKGR 15 1 O43196-3;O43196-2;O43196;O43196-4;A0A024RCV8;A0A0G2JK88;A0A140T982;A0A140T9J3;A0A0G2JK42;H7C2J4;A0A140T927;A2ABF0;A0A0G2JHB4;A0A0G2JJ70;A0A140T9I9;A0A140T9P6;H0YF11;H0YDS7;A0A140T967 O43196-3 MSH5;MSH5-SAPCD1 MutS protein homolog 5 1 10693000.0 1201500.0 2117600.0 7373900.0 True False 1822763.3414158875 1739697.7351156827 5916445.432904813 1.0 0.9544287486955487 3.2458659324962245 20.79769583046575 -6.902363278759156 0.9462004980445178 0.910808774772277 3.4982814748854767 0.9877059563248027 0.11859725055249407 0.10968685948063278 0.16776893395435305 0.09357101875149175 0.24647502248511177 1.2520933853800423e-07 6.902363278759156 2.5874727001132 up TFVPQFQEAAFANGK(ub)L ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFVPQFQEAAFANGKL 16 1 Q9NXR7 Q9NXR7 BRE BRCA1-A complex subunit BRE 1 35716200.0 8661100.0 8010100.0 19045000.0 True False 8386158.121346442 11208574.702119682 14056543.162246889 1.0 1.3365565661812355 1.6761600435921706 22.999578601837566 -6.971013519242243 0.2327163274541358 0.8664934005130644 2.155958447980953 0.9999892425594863 0.0009053593565452587 0.07597522332394224 0.00784381928530857 0.008553944961842511 0.03355400625777936 1.0690216009114298e-07 6.971013519242243 1.2894650474678884 TFVPQFQEAAFANGK(ub)L ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFVPQFQEAAFANGKL 16 1 Q9NXR7 Q9NXR7 BRE BRCA1-A complex subunit BRE 1 6465900.0 1163700.0 1322400.0 3979800.0 True False 1593951.3378100384 1263971.9954079879 3039853.2065538517 1.0 0.7929802908190311 1.9071179492407635 20.604176154881056 -6.858707137811632 1.192304916615066 0.8880466245355648 1.959737656908601 0.9520415946902577 0.10596092352411078 0.14814216734688757 0.40092136234978465 0.0693513709188269 0.16165276521637573 1.3844996879233766e-07 6.858707137811632 1.0716910323730362 TFVPQFQEAAFANGK(ub)L ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFVPQFQEAAFANGKL 16 1 Q9NXR7 Q9NXR7 BRE BRCA1-A complex subunit BRE 1 27904300.0 8661100.0 9594200.0 9649000.0 True False 7202088.401787051 9542514.140300402 11666561.28806472 1.0 1.3249648724018193 1.6198858771533409 22.779983877271842 -6.972280886067089 0.19621178464526867 0.8156415152650555 2.137318810756319 0.9999951346094375 0.0005583952561833886 0.07556941033128368 0.006306169682937316 0.009880434668235306 0.03161620340536358 1.0659065082133763e-07 6.972280886067089 1.3216772954912637 TFVPQFQEAAFANGK(ub)L ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFVPQFQEAAFANGKL 16 1 Q9NXR7 Q9NXR7 BRE BRCA1-A complex subunit BRE 1 54135800.0 0.0 47048000.0 7087800.0 True False 0.0 44429737.441484205 5797893.126969448 0.0 TFVSGACDASIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFVSGACDASIK 12 0 P62879;E7EP32;C9JIS1;C9JXA5;P62879-2 P62879;P62879-2 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0 10434300.0 2962500.0 3893200.0 3578600.0 False True 3883866.1888908087 3312349.7355747414 3208320.8003551327 1.0 0.8528485726540217 0.8260636809610054 21.889062065665943 -13.999999999999998 0.23960163157064102 1.9721250277974531 0.8141759480914926 0.9995242984899496 0.0016677797821301674 13.609410075035402 0.15492710362236087 6.328692948493471 0.01311882075393572 1.0000000000000041e-14 13.999999999999998 -1.1579490797059604 TFVSGACDASIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFVSGACDASIK 12 0 P62879;E7EP32;C9JIS1;C9JXA5;P62879-2 P62879;P62879-2 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0 24829100.0 5125900.0 15958000.0 3745200.0 False True 7776365.0534862345 13110170.219576914 3004959.5784205287 1.0 1.685899533960211 0.38642213396005254 22.89066451569743 -6.763279007277161 1.600011826912669 1.3967738468988131 0.38086821629477513 0.7042736275570834 0.28864378863119605 0.27743239639372985 1.400479411449327 0.1422866389154312 0.34085522045994854 1.7247295042246638e-07 6.763279007277161 -1.015905630604038 TFVSGACDASIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFVSGACDASIK 12 0 P62879;E7EP32;C9JIS1;C9JXA5;P62879-2 P62879;P62879-2 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 0 7894400.0 2962500.0 1944100.0 2987800.0 False True 4057816.3085522335 1858203.2337210116 2282143.1756725423 1.0 0.4579318264862487 0.5624067237500892 21.952272127188834 -9.958172990039392 5.850692673801149 1.0000003932206973 0.5101692751181274 0.9670069308174494 0.04265169820504931 2.1872831769334174e-07 3.902198762466866e-08 0.04129736182246074 0.01376577640286634 1.1011006270572503e-10 9.958172990039392 -0.48983111810256996 TFVSGACDASIK(ub)LWDVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFVSGACDASIKLWDVR 17 1 P62879;E7EP32;C9JIS1;C9JXA5;P62879-2 P62879;P62879-2 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 6465400.0 1402000.0 1991400.0 3072000.0 True False 1838035.5769873133 1694290.8824164036 2754138.90870479 1.0 0.921794389417359 1.498414363240478 20.809733261003583 -6.872663306173495 1.1198548231270875 0.9549664094746632 1.533946756493319 0.9672724811473685 0.04620224296268463 0.13432969735141467 0.3132229270865703 0.031963256414507944 0.07604763729178542 1.34071569616375e-07 6.872663306173495 0.5789803470186557 TFVSGACDASIK(ub)LWDVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFVSGACDASIKLWDVR 17 1 P62879;E7EP32;C9JIS1;C9JXA5;P62879-2 P62879;P62879-2 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 25406300.0 9964800.0 4572500.0 10869000.0 True False 9648472.878455745 6398323.095272495 8022082.836989311 1.0 0.6631436058196765 0.8314354963780817 23.201869185795665 -10.154985781329463 5.0333524253793245 1.0000141048571747 0.7472895510984562 0.7504045322722829 0.06870487662086862 1.0875265183841906e-05 1.8257476479323523e-06 0.0665269218901231 0.02217440357944468 6.998649089935244e-11 10.154985781329463 -0.2527245537587185 TFVSGACDASIK(ub)LWDVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFVSGACDASIKLWDVR 17 1 P62879;E7EP32;C9JIS1;C9JXA5;P62879-2 P62879;P62879-2 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 219406700.0 15355000.0 57485000.0 146566700.0 True False 23294657.600866392 47226352.617645055 117597727.50253326 1.0 2.027346931937243 5.048270273702562 24.47349578919912 -6.951900093870474 0.5375793428465745 0.9548021805256113 6.2597440378388525 0.9993420826409393 0.0440716662300819 0.0827316194957029 0.03287327360422925 0.04863660045593427 0.25008089589078863 1.1171202031971363e-07 6.951900093870474 5.304941857313241 TFVSGACDASIK(ub)LWDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFVSGACDASIKLWDVR 17 1 P62879;E7EP32;C9JIS1;C9JXA5;P62879-2 P62879;P62879-2 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 11444800.0 1402000.0 1211700.0 8831100.0 True False 1920357.2876253952 1158163.0874439336 6745376.062213602 1.0 0.6030977125491331 3.512563055677285 20.872943322526474 -6.872446479904618 1.1210149852211782 0.7718142828056432 3.691113046089706 0.9670672998197762 0.23377722457955386 0.1345336927657967 0.3144849086439431 0.16158584204659737 0.3842887470947483 1.341385230257296e-07 6.872446479904618 2.9192987632840626 up TFVSGACDASIK(ub)LWDVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFVSGACDASIKLWDVR 17 1 P62879;E7EP32;C9JIS1;C9JXA5;P62879-2 P62879;P62879-2 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 50730000.0 9964800.0 2556500.0 38208700.0 True False 8286172.715489675 2542727.627074482 46197962.512931794 1.0 0.30686394242317194 5.5753076962265204 22.98227446122994 -6.873785010687934 1.113946694083186 0.5974584214910347 5.906792786496309 0.9683136647627296 0.41607011577143477 0.13327411532508168 0.30680948313500755 0.28916745055098275 0.689450642325445 1.337257336806338e-07 6.873785010687934 5.309334365005275 up TFVSGACDASIK(ub)LWDVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFVSGACDASIKLWDVR 17 1 P62879;E7EP32;C9JIS1;C9JXA5;P62879-2 P62879;P62879-2 GNB2 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 1 216358400.0 15355000.0 67473400.0 133530000.0 True False 19877350.19230061 63718445.97611447 109228910.13350114 1.0 3.205580490340985 5.495144427037886 24.24462211129157 -6.970655628214599 0.24201525229765852 0.19815681563060938 8.56895604720168 0.9999870542482603 0.006603235103312058 0.0760905479896104 0.008265265431302569 0.05395732498926369 0.22241639273243793 1.0699029174863794e-07 6.970655628214599 8.370799231571072 TFVSGACDASSK(ub)LWDIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFVSGACDASSKLWDIR 17 1 Q9HAV0;H7C5J5 Q9HAV0 GNB4 Guanine nucleotide-binding protein subunit beta-4 1 21510600.0 3484600.0 6151000.0 11875000.0 True False 4568344.344914401 5233294.776410209 10646288.913043411 1.0 1.145556109892646 2.3304479936796216 22.123239969144237 -6.929773233034813 0.7486517251034764 0.9818295471311786 2.57230115078365 0.9964935276995569 0.03528305475489006 0.0927555242027885 0.0782582164653404 0.03210143330840013 0.10734606288567931 1.1755111881627487e-07 6.929773233034813 1.5904716036524713 up TFVSGACDASSK(ub)LWDIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFVSGACDASSKLWDIR 17 1 Q9HAV0;H7C5J5 Q9HAV0 GNB4 Guanine nucleotide-binding protein subunit beta-4 1 15057100.0 5500700.0 4066800.0 5489600.0 True False 5326083.289430953 5690694.448081833 4051709.075530085 1.0 1.0684576524318372 0.7607295746895795 22.344643558952207 -6.848326784848093 1.2430754419896308 1.0364868732589942 0.7488150343220997 0.9378432268998594 0.03289009258885543 0.15930758258652208 0.4745435780868424 0.020712089801846238 0.04788240213365819 1.4179901535915344e-07 6.848326784848093 -0.2876718389368945 TFVSGACDASSK(ub)LWDIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFVSGACDASSKLWDIR 17 1 Q9HAV0;H7C5J5 Q9HAV0 GNB4 Guanine nucleotide-binding protein subunit beta-4 1 182256000.0 15529000.0 47297000.0 119430000.0 True False 23558628.321970325 38856480.81685232 95824608.15197147 1.0 1.6493524277309266 4.067495222657224 24.48975220632133 -6.946519226442774 0.5958341129007595 0.9724942392213625 4.867256476079964 0.9988990429991119 0.04379429724027918 0.0849142984276024 0.041984266299484624 0.0451345505031901 0.20294351976091907 1.1310473161719082e-07 6.946519226442774 3.8947622368586017 TFVSGACDASSK(ub)LWDIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFVSGACDASSKLWDIR 17 1 Q9HAV0;H7C5J5 Q9HAV0 GNB4 Guanine nucleotide-binding protein subunit beta-4 1 31418200.0 3484600.0 6499600.0 21434000.0 True False 4772950.787774215 6212426.180697034 16371730.647086611 1.0 1.3015902440498646 3.430106735862929 22.186450030667128 -6.932505440978514 0.725938311534055 0.9704490598218973 3.896322580103774 0.9970080341020114 0.05915732197019372 0.09135778258429074 0.07146063419636775 0.05472171461458738 0.19001062560189555 1.1681390949539151e-07 6.932505440978514 2.9258735202818764 up TFVSGACDASSK(ub)LWDIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFVSGACDASSKLWDIR 17 1 Q9HAV0;H7C5J5 Q9HAV0 GNB4 Guanine nucleotide-binding protein subunit beta-4 1 46856700.0 5500700.0 1790000.0 39566000.0 True False 4574075.772328004 1780356.9147128179 47839067.66748568 1.0 0.38922768299631694 10.458739655538693 22.125048834386483 -6.892477416674902 1.0076369289105518 0.4906459584396834 11.367963010403315 0.9824363431215786 0.6109010834896452 0.11715513305324429 0.21030226355950232 0.46038985305700536 1.1584559835216481 1.2809217007684485e-07 6.892477416674902 10.877317051963631 up TFVSGACDASSK(ub)LWDIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFVSGACDASSKLWDIR 17 1 Q9HAV0;H7C5J5 Q9HAV0 GNB4 Guanine nucleotide-binding protein subunit beta-4 1 137213000.0 15529000.0 32672000.0 89012000.0 True False 20102596.62235339 30853774.479003794 72812729.3402473 1.0 1.5348153802526918 3.6220559317835623 24.26087852841378 -6.945440513136838 0.606841029756553 0.976799318481936 4.288181108850176 0.9987931456262658 0.03929981673577414 0.08536992761793924 0.043949426251352224 0.04006773640942358 0.17580837938186375 1.1338601363336341e-07 6.945440513136838 3.3113817903682397 TFVVQGFGNVGLHSMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFVVQGFGNVGLHSMR 16 0 P00367;P00367-3;P00367-2;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 19191800.0 8678400.0 4253200.0 6260200.0 False True 8402908.942315992 5951524.940144995 4620465.818025619 1.0 0.7082695981832987 0.549865034804499 23.002457419852973 -13.99999999999867 0.0745240767385054 2.630928438801951 0.024888930041568197 0.9999082621258456 0.0017856574520042456 12.313725674351904 0.07517952967728356 3.401955300842681 0.4802653607746298 1.0000000000030636e-14 13.99999999999867 -2.606039508760383 TFVVQGFGNVGLHSMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFVVQGFGNVGLHSMR 16 0 P00367;P00367-3;P00367-2;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 65749000.0 11484000.0 29888000.0 24377000.0 False True 17422067.592859004 24554252.88399017 19558875.26518133 1.0 1.409376513615096 1.1226494881237956 24.054412512543067 -10.079185266873312 4.894989833732795 0.9999917296804363 1.2660130008715345 0.5343734872818368 0.11705581799382708 1.056538711900043e-05 1.9874510394944415e-06 0.11334233051285998 0.0377796028045361 8.333256181246414e-11 10.079185266873312 0.2660212711910982 TFVVQGFGNVGLHSMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFVVQGFGNVGLHSMR 16 0 P00367;P00367-3;P00367-2;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 13027400.0 2062100.0 4608900.0 6356400.0 False True 2824514.0961571545 4405263.558405837 4855149.234167265 1.0 1.5596535929487287 1.7189325557882176 21.42957126999934 -11.402919815388708 0.22642374625946085 1.8753331284298078e-09 1.811967603388486 0.9993167491283653 0.00805870056012948 3.805328301228232 0.12886932669528844 1.968285649205277 0.08388086492250914 3.9543962409391836e-12 11.402919815388708 1.8119676015131527 TFVVQGFGNVGLHSMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFVVQGFGNVGLHSMR 16 0 P00367;P00367-3;P00367-2;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 17384900.0 8678400.0 4653700.0 4052800.0 False True 7216474.118307007 4628629.59441287 4900221.741970016 1.0 0.6413976574336765 0.6790326774039084 22.78286269528725 -9.93624765082531 6.966895695551506 1.0000000131872766 0.6602151677320429 0.9908828321009258 0.015364432564425002 3.1680224463723555e-09 4.454623905145364e-10 0.014876548526517102 0.00495884928716142 1.158116766681811e-10 9.93624765082531 -0.3397848454552337 TFVVQGFGNVGLHSMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFVVQGFGNVGLHSMR 16 0 P00367;P00367-3;P00367-2;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 64061000.0 11484000.0 32787000.0 19790000.0 False True 14866264.383482937 30962374.6279107 16188423.062547667 1.0 2.08272729646267 1.0889368468741687 23.825538834635516 -6.625865068854314 2.096345267440908 1.7154750024492424 1.0929261271003543 0.10260664105805795 0.4649246185647805 0.5697612039951159 4.766339888770263 0.18177421325360404 0.5149217721324122 2.3666548803297725e-07 6.625865068854314 -0.6225488753488881 TFYGLHQDFPSVVLVGLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFYGLHQDFPSVVLVGLGK 19 0 P28838-2;P28838 P28838-2 LAP3 Cytosol aminopeptidase 0 37782470.0 15068380.0 15531870.0 7182220.0 False True 19754792.10239949 13214575.53875506 6439072.7711190535 1.0 0.6689301244101662 0.32594991320293065 24.23569932781816 -7.273948318501818 0.28298389316301076 1.0878240184453574 2.60739775510363e-14 0.9999091207046822 0.0026234365554931097 0.10114323244906993 0.01803967155702929 0.013012766033586172 0.0460484584325398 5.321715844747313e-08 7.273948318501818 -1.0878240184453314 down TFYGLHQDFPSVVLVGLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TFYGLHQDFPSVVLVGLGK 19 0 P28838-2;P28838 P28838-2 LAP3 Cytosol aminopeptidase 0 205922630.0 100748300.0 55311330.0 49863000.0 False True 97550100.36333126 77397432.51377541 36802384.44206444 1.0 0.7934121259281537 0.3772664949086852 26.53964002134728 -6.959904898470909 0.4367778091086473 1.0153894932414331 0.13915087133416132 0.9997666403711769 0.003956259214487757 0.0797351941572485 0.021257507130097282 0.005465480500340539 0.034502042308631325 1.0967183285314046e-07 6.959904898470909 -0.8762386219072718 down TFYGLHQDFPSVVLVGLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TFYGLHQDFPSVVLVGLGK 19 0 P28838-2;P28838 P28838-2 LAP3 Cytosol aminopeptidase 0 248723700.0 75602700.0 115903000.0 57218000.0 False True 114694823.19772215 95219204.09572768 45908837.22045969 1.0 0.8301961800976798 0.40026947982924693 26.773225035234507 -6.955189561269844 0.498631877895077 1.008713146764862 0.2032526163880459 0.9995480977733817 0.005365491453314552 0.08146645645588976 0.027838475266936405 0.006308644279176772 0.03546351547591382 1.1086907872229095e-07 6.955189561269844 -0.8054605303768161 down TFYGLHQDFPSVVLVGLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFYGLHQDFPSVVLVGLGK 19 0 P28838-2;P28838 P28838-2 LAP3 Cytosol aminopeptidase 0 71419210.0 15068380.0 15730930.0 40619900.0 False True 20639567.293658163 15035885.497370986 31026316.21310034 1.0 0.7284980970502711 1.5032445095219449 24.298909389341052 -6.812037904377989 1.4060746997187337 0.8523844387285959 1.5174217952401288 0.8650372820533234 0.11791591893993486 0.204045647142143 0.7947061185438062 0.06593512384344147 0.15237658261963785 1.541565902203279e-07 6.812037904377989 0.6650373565115328 TFYGLHQDFPSVVLVGLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TFYGLHQDFPSVVLVGLGK 19 0 P28838-2;P28838 P28838-2 LAP3 Cytosol aminopeptidase 0 169922180.0 100748300.0 40223310.0 28950570.0 False True 83776675.3564516 40006619.04532808 35004000.33468833 1.0 0.477538871948649 0.41782513075093863 26.320045296781558 -13.999999999999998 0.30614198006506743 5.937945257504383 0.4040468699869569 0.999663484778038 0.0047971172103457365 16.999652597089163 0.17591303317070647 53.357884545546106 0.02102573994542465 1.0000000000000041e-14 13.999999999999998 -5.533898387517426 TFYGLHQDFPSVVLVGLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFYGLHQDFPSVVLVGLGK 19 0 P28838-2;P28838 P28838-2 LAP3 Cytosol aminopeptidase 0 177403100.0 75602700.0 56353400.0 45447000.0 False True 97869185.50201544 53217283.75138013 37176112.325598985 1.0 0.543759340372606 0.3798551314686624 26.544351357326956 -13.999999999999998 0.14250999444330317 3.184699766946166 0.18302040794808896 0.9995931192011731 0.005292583453123168 11.937414877833701 0.11845296472492617 7.242808158882851 0.17628153133882285 1.0000000000000041e-14 13.999999999999998 -3.001679358998077 TFYSCTTEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TFYSCTTEGR 10 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 23994700.0 6344700.0 10262000.0 7388000.0 False True 8317963.142162202 8730949.600962693 6623560.630700187 1.0 1.0496499505638754 0.7962959822611614 22.987798861577303 -6.855833464000011 1.2065359374534528 1.0266943487454883 0.7849644277102331 0.9483788710285883 0.024905948764058057 0.15115740866997737 0.42050996516822287 0.016124710963182298 0.03748223204756319 1.393691129906577e-07 6.855833464000011 -0.24172992103525515 TFYSCTTEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TFYSCTTEGR 10 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 23736600.0 6344700.0 8812400.0 8579500.0 False True 8690507.049070502 8423039.029290183 6553198.800348954 1.0 0.9692229672825676 0.7540640337032872 23.051008923100195 -6.932693177522394 0.7243417808695182 1.0029673503311738 0.706702322822386 0.9970416194901809 0.005950644347565613 0.09126334956767887 0.07100428280494005 0.005510924637708482 0.019188015853283894 1.1676342416516694e-07 6.932693177522394 -0.2962650275087878 TFYSCTTEGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TFYSCTTEGR 10 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 11455600.0 6038400.0 3157300.0 2259900.0 False True 7816827.834658938 2981593.47951024 1848621.3885321603 1.0 0.3814326658558589 0.2364925296596121 22.898151832141416 -13.99999999999989 0.20385647484738517 4.490152823433497 0.1458594810220754 0.999487500295859 0.007495332195324954 12.609808230481537 0.14314628208119182 17.577363459987648 0.0897053630441908 1.0000000000002535e-14 13.99999999999989 -4.344293342411421 TGAAPIIDVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGAAPIIDVVR 11 0 E9PLL6;P46776;E9PJD9;E9PLX7 E9PLL6 RPL27A 60S ribosomal protein L27a 0 36367800.0 5323800.0 18460000.0 12584000.0 False True 6979553.355752535 15705839.956516404 11281928.394251643 1.0 2.250264330105261 1.616425553212957 22.73470328598 -10.159912876638181 5.728541114644049 0.9999856263009014 1.9333449416591546 0.7430043055389555 0.2587635970961503 4.7503618504765086e-05 6.966836852281629e-06 0.2505506230432058 0.0835155918464862 6.919697723284163e-11 10.159912876638181 0.9333593153582532 TGAAPIIDVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGAAPIIDVVR 11 0 E9PLL6;P46776;E9PJD9;E9PLX7 E9PLL6 RPL27A 60S ribosomal protein L27a 0 41383000.0 16603000.0 10427000.0 14353000.0 False True 16075946.853022719 14590555.476086682 10593518.719229687 1.0 0.907601624307638 0.6589670155097468 23.938400377188156 -6.953866255602768 0.5146516289087378 1.0044064556151122 0.5511673247127137 0.9994708031770758 0.0033129316539359873 0.08196939979559224 0.029817270244176217 0.003785910233384511 0.020527475431289594 1.1120741465226774e-07 6.953866255602768 -0.45323913090239853 TGAAPIIDVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGAAPIIDVVR 11 0 E9PLL6;P46776;E9PJD9;E9PLX7 E9PLL6 RPL27A 60S ribosomal protein L27a 0 140017000.0 23174000.0 104310000.0 12533000.0 False True 35156652.24633527 85695065.5222501 10055847.056590948 1.0 2.4375206410952557 0.2860297102844646 25.067294362179812 -6.726593177601471 1.7354416518152487 1.8683171376070475 0.28801029132534683 0.5435897857988155 0.6044736938414531 0.3426111283926587 2.0198496451463783 0.2761941909890946 0.688071467498778 1.8767517193041297e-07 6.726593177601471 -1.5803068462817007 TGAAPIIDVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGAAPIIDVVR 11 0 E9PLL6;P46776;E9PJD9;E9PLX7 E9PLL6 RPL27A 60S ribosomal protein L27a 0 45584800.0 5323800.0 26031000.0 14230000.0 False True 7292152.73028536 24880864.34699435 10869167.076049365 1.0 3.4120053799285555 1.4905292686627571 22.79791334750289 -6.589304034682728 2.230625686121224 2.633118456147387 1.4959268946508448 0.0 1.0453651085122622 0.6716005577178049 6.298353377498137 0.39129508485473347 1.1659512474617304 2.574518194025643e-07 6.589304034682728 -1.1371915614965422 TGAAPIIDVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGAAPIIDVVR 11 0 E9PLL6;P46776;E9PJD9;E9PLX7 E9PLL6 RPL27A 60S ribosomal protein L27a 0 26716900.0 16603000.0 5646600.0 4467300.0 False True 13806130.137611909 5616180.645037653 5401391.775538559 1.0 0.40678891108939685 0.3912314110978571 23.718805652622432 TGAAPIIDVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGAAPIIDVVR 11 0 E9PLL6;P46776;E9PJD9;E9PLX7 E9PLL6 RPL27A 60S ribosomal protein L27a 0 46363000.0 23174000.0 12540000.0 10649000.0 False True 29999199.827832926 11842137.976454088 8710991.26796716 1.0 0.3947484614395309 0.2903741205752161 24.83842068427226 -13.999999999999998 0.24727033941919305 5.152021667340856 0.24730351147093046 0.9995376338162218 0.00672679783748119 13.891438507062004 0.15735678853066387 28.60217195147741 0.04891027373701535 1.0000000000000041e-14 13.999999999999998 -4.904718155869926 TGAFEPAEASVNPQDLQGSLQELK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGAFEPAEASVNPQDLQGSLQELKER 26 1 Q9NVX2;A0A0A0MRH0;K7EN33;Q9NVX2-2 Q9NVX2 NLE1 Notchless protein homolog 1 1 13104600.0 1983300.0 2109300.0 9012000.0 True False 1649201.8250873738 2097936.7822367316 10896367.53321995 1.0 1.2720922026178234 6.607055223603495 20.653336532220543 -6.9174821155877355 0.8431845887692999 0.8712694585146185 7.419456525761886 0.9934525445099529 0.20888146645858877 0.09967617042735467 0.11345642552111114 0.17761312340853455 0.5198817226867967 1.209254979498756e-07 6.9174821155877355 6.548187067247268 up TGAFSIPVIQIVYETLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGAFSIPVIQIVYETLK 17 0 Q92499;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 864070000.0 326010000.0 331580000.0 206480000.0 False True 494581004.5235069 272406958.35363555 165669137.49660113 1.0 0.5507833011421052 0.33496866232501465 28.88163158999942 -11.15728571798446 0.1358206654533707 2.0497676687447433 1.2268147458656964e-12 0.9997244384877838 0.004598466280254379 3.5410928618276434 0.0820611075420913 1.3744929325221784 0.23260061475325877 6.9616836123664935e-12 11.15728571798446 -2.0497676687435162 TGAFSIPVIQIVYETLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGAFSIPVIQIVYETLK 17 0 Q92499;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 146510000.0 82913000.0 25791000.0 37806000.0 False True 68945833.16869344 25652058.763887342 45711059.80480623 1.0 0.37206104538795093 0.6629995998882565 26.038960027429923 -10.474717408103288 6.2208158881632505 1.0002604856061785 0.5175303226381625 0.7857161461615694 0.11877516750477728 0.00042932577440081424 3.62518794101412e-05 0.11506404217708913 0.03833452047408319 3.3518346937966146e-11 10.474717408103288 -0.4827301629680161 TGAFSIPVIQIVYETLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGAFSIPVIQIVYETLK 17 0 Q92499;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 681740000.0 326010000.0 202260000.0 153470000.0 False True 422026371.61783904 191004053.19917086 125540034.73517886 1.0 0.4525879566884799 0.2974696445009369 28.652757912091868 -13.999999999999998 0.176873656366422 3.8137907156043647 0.17019075909131678 0.9995022436424702 0.0067231053128779025 12.165885512872075 0.13328888011321613 11.756701134858423 0.11896913663033594 1.0000000000000041e-14 13.999999999999998 -3.643599956513048 TGAHLELSLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGAHLELSLAK 11 0 A0A024R4E5;Q00341;Q00341-2;C9JIZ1;C9J5E5;H7C0A4;C9JZI8;C9JES8;C9JHS7;C9JHZ8 A0A024R4E5 HDLBP Vigilin 0 13675600.0 3174500.0 4660000.0 5841100.0 False True 4161800.2419017293 3964746.1645377316 5236719.003787617 1.0 0.9526517213920979 1.258282161422218 21.988776289579086 -6.86734699789209 1.1481141769456769 0.9736092216115878 1.2752958371455831 0.9619587865184497 0.026196751716222808 0.13941988826758028 0.3451537067840727 0.017735763186908154 0.04180505614549591 1.3572285982243868e-07 6.86734699789209 0.30168661553399534 TGAHLELSLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGAHLELSLAK 11 0 A0A024R4E5;Q00341;Q00341-2;C9JIZ1;C9J5E5;H7C0A4;C9JZI8;C9JES8;C9JHS7;C9JHZ8 A0A024R4E5 HDLBP Vigilin 0 14718700.0 5010800.0 3928500.0 5779400.0 False True 4851734.896773247 5497170.536856863 4265601.761716443 1.0 1.1330319264790987 0.8791910218658846 22.21006929176128 -6.764298070423072 1.5962964346751012 1.0768575128276467 0.878061190810577 0.7082792890868683 0.05599346890959223 0.27574726181943426 1.3857365986676236 0.02766413890553336 0.06620212111653971 1.7206872060525056e-07 6.764298070423072 -0.19879632201706976 TGAHLELSLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGAHLELSLAK 11 0 A0A024R4E5;Q00341;Q00341-2;C9JIZ1;C9J5E5;H7C0A4;C9JZI8;C9JES8;C9JHS7;C9JHZ8 A0A024R4E5 HDLBP Vigilin 0 34476200.0 9428200.0 13701000.0 11347000.0 False True 14303268.69374724 11255949.503598414 9104260.476433216 1.0 0.7869494550234536 0.6365160769449293 23.76984154473834 -7.235697409506712 0.08986642158171407 1.4588795857329446 3.8096761415169924e-08 0.9999995181022929 0.00010335893923157542 0.09832806938523468 0.004295863899378253 0.02701326180714654 0.04149012819785579 5.8116920052809736e-08 7.235697409506712 -1.458879547636183 TGAHLELSLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGAHLELSLAK 11 0 A0A024R4E5;Q00341;Q00341-2;C9JIZ1;C9J5E5;H7C0A4;C9JZI8;C9JES8;C9JHS7;C9JHZ8 A0A024R4E5 HDLBP Vigilin 0 14336000.0 3174500.0 4182800.0 6978700.0 False True 4348198.437636815 3997990.065330101 5330474.790838072 1.0 0.91945897195597 1.2259042146510477 22.051986351101977 -6.836858222913687 1.296954153968747 0.9571220728818453 1.2353695633569342 0.9189077727603308 0.03693786742028573 0.17250100182769473 0.5650031388676693 0.02234363219394396 0.05143883465091749 1.4559342983016277e-07 6.836858222913687 0.2782474904750889 TGAHLELSLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGAHLELSLAK 11 0 A0A024R4E5;Q00341;Q00341-2;C9JIZ1;C9J5E5;H7C0A4;C9JZI8;C9JES8;C9JHS7;C9JHZ8 A0A024R4E5 HDLBP Vigilin 0 15079300.0 5010800.0 4958600.0 5109900.0 False True 4166702.216078162 4931887.037594962 6178356.464491852 1.0 1.1836427903496827 1.4827929004984486 21.990474567195555 -6.963850356569002 0.37726621425439144 0.97880909707453 1.6981595123374307 0.9998874448752241 0.0021109132198059016 0.07835331418011582 0.016249202729714474 0.0039048193946370803 0.025311575330471476 1.0868000342463848e-07 6.963850356569002 0.7193504152629007 TGAHLELSLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGAHLELSLAK 11 0 A0A024R4E5;Q00341;Q00341-2;C9JIZ1;C9J5E5;H7C0A4;C9JZI8;C9JES8;C9JHS7;C9JHZ8 A0A024R4E5 HDLBP Vigilin 0 34283200.0 9428200.0 16468000.0 8387000.0 False True 12204990.75760657 15551541.323464561 6860652.057887177 1.0 1.274195256049031 0.5621185787143167 23.54096786683079 -6.802326371027561 1.4465237229938157 1.1508418055228082 0.551729293601649 0.8388430034559549 0.11772458784431694 0.21745441474663685 0.8980605274083148 0.06401953169446067 0.1486713153134308 1.576426144828558e-07 6.802326371027561 -0.5991125119211592 TGAIVDVPVGEELLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGAIVDVPVGEELLGR 16 0 P25705;P25705-2;K7EK77;K7ERX7;K7EJP1;K7EQH4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 128619000.0 32886000.0 50194000.0 45539000.0 False True 43113864.46847701 42705250.85467961 40827061.12093337 1.0 0.9905224544625044 0.9469589800001423 25.36164854706276 -6.941698918162544 0.6435704997565818 1.0004782526511282 0.9346001568393206 0.9983779411787852 0.0009301806127312265 0.08700012174384071 0.051145001359751883 0.0009175701977660304 0.003722256374057396 1.1436709288185181e-07 6.941698918162544 -0.06587809581180759 TGAIVDVPVGEELLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGAIVDVPVGEELLGR 16 0 P25705;P25705-2;K7EK77;K7ERX7;K7EJP1;K7EQH4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 155267000.0 55075000.0 34520000.0 65672000.0 False True 53326674.27153076 48304016.01942186 48470533.082230374 1.0 0.9058133978778736 0.9089359826833808 25.668354021079598 -10.273361576766694 5.389208143036652 1.000011238883348 0.9073746908413732 0.9991483340626098 0.0012747899086979976 1.7216447793165682e-07 2.321312993590933e-08 0.001234459767593476 0.00041143667385536294 5.328910462995786e-11 10.273361576766694 -0.09263654804197474 TGAIVDVPVGEELLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGAIVDVPVGEELLGR 16 0 P25705;P25705-2;K7EK77;K7ERX7;K7EJP1;K7EQH4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 305147000.0 41619000.0 218350000.0 45178000.0 False True 63139065.75646106 179383736.52366322 36248548.49777916 1.0 2.8410894962491073 0.5741065070173267 25.91202957803804 -6.690672599424998 1.8638642677284063 2.153484204016774 0.5818338284056436 0.37371057116402573 0.7785393010203201 0.41518965736074925 2.7969736514313164 0.33407967427351026 0.8692816429442712 2.0385783168856835e-07 6.690672599424998 -1.5716503756111302 TGAIVDVPVGEELLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGAIVDVPVGEELLGR 16 0 P25705;P25705-2;K7EK77;K7ERX7;K7EJP1;K7EQH4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 223222000.0 32886000.0 104720000.0 85616000.0 False True 45044842.91073376 100093124.13726902 65395264.11686874 1.0 2.2220773271565295 1.4517813780916897 25.42485860858565 -10.082216937412166 4.886982963827763 0.9999760230568476 1.8369293525567796 0.6114976310990581 0.3144720043859083 9.382897623390617e-05 1.7620804643514383e-05 0.30449614304475975 0.10149540298208115 8.275286959252635e-11 10.082216937412166 0.836953329499932 TGAIVDVPVGEELLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGAIVDVPVGEELLGR 16 0 P25705;P25705-2;K7EK77;K7ERX7;K7EJP1;K7EQH4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 116144000.0 55075000.0 37988000.0 23081000.0 False True 45797302.736190744 37783351.10397241 27907130.38551371 1.0 0.8250125847283708 0.6093618776256108 25.448759296513874 -6.9683176074809365 0.295635184349685 1.0393951390751768 0.3882638611041348 0.9999661161226198 0.0009299724424155347 0.07685259810008653 0.010974518198248923 0.0036574901025182766 0.01943213679605462 1.0756782627633499e-07 6.9683176074809365 -0.651131277971042 TGAIVDVPVGEELLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGAIVDVPVGEELLGR 16 0 P25705;P25705-2;K7EK77;K7ERX7;K7EJP1;K7EQH4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 141264000.0 41619000.0 52578000.0 47067000.0 False True 53876615.9331397 49651988.080223426 38501288.94820265 1.0 0.921586985749829 0.7146196597793435 25.68315590013049 -6.954288172976204 0.5095973316392025 1.0038217095784665 0.6233111940397678 0.9994962507953327 0.002701886186293559 0.08180816501877075 0.029179560135044733 0.003114211103297321 0.01708105539064831 1.1109942903868267e-07 6.954288172976204 -0.38051051553869875 TGALLLQGFIQDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGALLLQGFIQDR 13 0 Q07812-5;Q07812-7;Q07812-8;Q07812;Q07812-2 Q07812-5 BAX Apoptosis regulator BAX 0 3535510.0 1185000.0 1394100.0 956410.0 False True 1553546.4755563242 1186105.7141592386 857449.8677325344 1.0 0.7634826075830752 0.5519306188928027 20.56713397077858 -6.972445929256456 0.1909276170593821 1.1416518938725482 0.1679764585132597 0.9999957056934995 0.00037921929534910864 0.0755167226286033 0.006097643197006738 0.007409929761915181 0.023002542888135337 1.0655015129991965e-07 6.972445929256456 -0.9736754353592885 TGAPQYGSYGTAPVNLNIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGAPQYGSYGTAPVNLNIK 19 0 Q6UN15-3;Q6UN15-5;Q6UN15;Q6UN15-4;A0A0B4J203 Q6UN15-3 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 0 7452500.0 1881700.0 2873800.0 2697000.0 False True 2466926.9224087237 2445040.24198466 2417940.3114507846 1.0 0.9911279575307834 0.9801426582551103 21.234283548748156 -6.968257813179476 0.2970590843574847 1.0019730583371964 0.9689548759386765 0.9999648103975893 4.783329479800722e-05 0.07687405397201323 0.01105356900256202 0.00018496088467376766 0.0009883238624744334 1.075826373920637e-07 6.968257813179476 -0.033018182398519946 TGAPQYGSYGTAPVNLNIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGAPQYGSYGTAPVNLNIK 19 0 Q6UN15-3;Q6UN15-5;Q6UN15;Q6UN15-4;A0A0B4J203 Q6UN15-3 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 0 5215300.0 1466700.0 1165700.0 2582900.0 False True 1420140.4113309893 1631170.0890451944 1906361.0046609335 1.0 1.1485977555672986 1.3423750140834643 20.437602147445922 -6.967479238120413 0.3125917838474585 0.9710461226312704 1.526109448945637 0.9999555076910601 0.000935012457689769 0.07712944473538928 0.0119437479679231 0.0030307129847163146 0.017161069164622806 1.0777567756972076e-07 6.967479238120413 0.5550633263143666 TGAPQYGSYGTAPVNLNIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGAPQYGSYGTAPVNLNIK 19 0 Q6UN15-3;Q6UN15-5;Q6UN15;Q6UN15-4;A0A0B4J203 Q6UN15-3 FIP1L1 Pre-mRNA 3-end-processing factor FIP1 0 6627600.0 1881700.0 2615600.0 2130300.0 False True 2577415.341030463 2500034.1433674623 1627167.0149056923 1.0 0.9699772107230248 0.6313173468794296 21.297493610271047 -6.924306102013378 0.7921349072465572 1.006377723988774 0.5709033732528452 0.9952958611965844 0.011465789244522443 0.09570399873633223 0.09296716172382206 0.010111352967484903 0.03165622644020899 1.1904026855905668e-07 6.924306102013378 -0.43547435073592866 TGASFQK(ub)AQQEFAAGVFSNPAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGASFQKAQQEFAAGVFSNPAVR 23 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 69616000.0 18797000.0 34116000.0 16703000.0 True False 24643049.030406952 29026025.783126425 14974733.786489613 1.0 1.1778585412588896 0.6076656248182745 24.554677432781208 -6.822906609118191 1.3593866030298634 1.0955907707973853 0.594437591600108 0.8909142167469319 0.07867508071998822 0.18972863771708595 0.6881343577040336 0.04547217019598841 0.10472660707591816 1.5034652371751778e-07 6.822906609118191 -0.5011531791972773 TGASFQK(ub)AQQEFAAGVFSNPAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGASFQKAQQEFAAGVFSNPAVR 23 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 97371000.0 30841000.0 31362000.0 35168000.0 True False 29861969.33650991 43885010.15066945 25956445.782614786 1.0 1.469595312222582 0.8692141328696583 24.831805975642816 -6.697987227594299 1.8375976501145825 1.2921575457446097 0.8710367760072669 0.4083028234409023 0.19829371731991546 0.3996876326574943 2.6223815826375154 0.08612572486236976 0.2220816479977635 2.0045309788542782e-07 6.697987227594299 -0.4211207697373428 TGASFQK(ub)AQQEFAAGVFSNPAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGASFQKAQQEFAAGVFSNPAVR 23 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 176193000.0 44099000.0 68694000.0 63400000.0 True False 66901407.068746865 56435018.99132823 50868962.21079288 1.0 0.8435550381374859 0.7603571350677379 25.995533218123953 -13.999999999999297 0.07859986309068927 1.8509276717862124 0.5053441348703983 0.9998923944812901 0.001030524512309018 12.272428953808012 0.07847386867653915 1.8276096075650878 0.23200398366486175 1.0000000000016197e-14 13.999999999999297 -1.345583536915814 TGASFQK(ub)AQQEFAAGVFSNPAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGASFQKAQQEFAAGVFSNPAVR 23 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 66748000.0 18797000.0 23963000.0 23988000.0 True False 25746758.869824942 22904235.424955815 18322528.448367715 1.0 0.8895968436555116 0.7116440768722007 24.6178874943041 -6.964034642424566 0.37425207396248455 1.013041748153718 0.5819633086888433 0.9998918374351858 0.0012354444238866168 0.07829009859120147 0.01602454729699593 0.0023314878854862027 0.015079737993535288 1.0863389660189469e-07 6.964034642424566 -0.4310784394648747 TGASFQK(ub)AQQEFAAGVFSNPAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGASFQKAQQEFAAGVFSNPAVR 23 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 84081000.0 30841000.0 28997000.0 24243000.0 True False 25645657.98795935 28840787.40554612 29312099.21303276 1.0 1.1245875391103977 1.142965379433618 24.612211251077092 -13.999999999999998 0.2695145944548405 0.04088936404595554 1.1490944038396131 0.999582277734633 0.0012979710110782266 14.85942919004758 0.16433894858926637 7.806510670553902 0.007651305627381676 1.0000000000000041e-14 13.999999999999998 1.1082050397936576 TGASFQK(ub)AQQEFAAGVFSNPAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGASFQKAQQEFAAGVFSNPAVR 23 1 O14828;O14828-2 O14828 SCAMP3 Secretory carrier-associated membrane protein 3 1 126532000.0 44099000.0 47244000.0 35189000.0 True False 57087024.82124816 44614829.86918628 28784963.069630593 1.0 0.7815231220909652 0.5042295190503017 25.766659540216402 -6.967884615722395 0.3045042399689043 1.0455888961889475 0.23141889814302527 0.9999608625258364 0.001269151081054514 0.07699524111515853 0.011474065049563598 0.004500714884329754 0.024753142572970985 1.0767512491828765e-07 6.967884615722395 -0.8141699980459222 TGCNVLLIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGCNVLLIQK 10 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 43833500.0 8130500.0 20020000.0 15683000.0 False True 10659164.235874 17033094.037348792 14060273.60195872 1.0 1.5979765073909813 1.319078427803758 23.34559098785937 -10.012825634504358 4.429847350029555 0.9999809414705446 1.4585274674859725 0.782795068286565 0.11385966443221429 14888834.072841112 8413343.448308764 2578.3782295317783 0.03897719118642136 9.708996968735267e-11 10.012825634504358 0.4585465260154279 TGCNVLLIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGCNVLLIQK 10 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 38429500.0 8130500.0 13266000.0 17033000.0 False True 11136565.568500906 12679864.255204432 13010156.205646444 1.0 1.1385794100713287 1.168237741305531 23.408801049382262 -13.99999998752001 0.2166749701153806 0.17573467231107415 1.184616480344096 0.9994947815898687 0.001648100291172113 12.911056002992462 0.14748571933409574 4.545632619438537 0.01678091888872366 1.0000000287362402e-14 13.99999998752001 1.0088818080330217 TGCNVLLIQK(ub)SILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGCNVLLIQKSILR 14 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 1 5067050.0 761150.0 1244000.0 3061900.0 True False 997875.0209870863 1058400.0490740212 2745083.95981875 1.0 1.0606539163863067 2.750929627543282 19.928499610747906 -6.914501716184566 0.8645057601531456 0.9548184751988764 2.991793698909163 0.9925126089615961 0.07021693679151861 0.10151611215271013 0.12317301050525842 0.058799101301199135 0.16785288147675864 1.21758218136373e-07 6.914501716184566 2.0369752237102867 up TGCNVLLIQK(ub)SILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGCNVLLIQKSILR 14 1 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 1 8123650.0 761150.0 1949500.0 5413000.0 True False 1042567.7243053289 1863364.6438656028 4134560.8842343804 1.0 1.787284030020378 3.965748016023871 19.991709672270797 -6.953252179166502 0.5219196541675842 0.9635237488739051 4.887045188975045 0.9994324133003544 0.029884404508645122 0.08220550913540439 0.03075660574722428 0.03375268699940719 0.17997733354747883 1.1136476906996813e-07 6.953252179166502 3.92352144010114 TGEAIVDAALSALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGEAIVDAALSALR 14 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 54748080.0 19743000.0 20333320.0 14671760.0 False True 25883264.19148397 17299667.914660573 13153667.016659692 1.0 0.6683727286743244 0.5081919698902377 24.62551623424321 -13.99999999988867 0.096022210259335 2.6587054287462033 0.1449655571136294 0.9998134629608318 0.002797205639085671 12.111875693154099 0.09145347494378658 4.0240509744577 0.3247728438577129 1.0000000002563459e-14 13.99999999988867 -2.513739871632574 TGEAIVDAALSALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGEAIVDAALSALR 14 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 108935000.0 38750000.0 32331000.0 37854000.0 False True 37519902.46067763 45240936.90393768 27938901.80434204 1.0 1.205785035058447 0.7446421758058442 25.161152741540317 -6.785363221084907 1.5145812160539835 1.1157075072871396 0.7403289478459569 0.7860463503284444 0.08724781745719308 0.24232057521469721 1.098129209697986 0.045353183264946334 0.10656280402895986 1.6392182437346278e-07 6.785363221084907 -0.3753785594411827 TGEAIVDAALSALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGEAIVDAALSALR 14 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 107025390.0 19743000.0 32736390.0 54546000.0 False True 27042520.63451368 31289988.045034863 41663358.21013274 1.0 1.1570662538424856 1.5406610490650363 24.688726295766102 -6.955960505289944 0.48905107850197005 0.9915326786103978 1.722434648344279 0.9995898123071091 0.004599272446226945 0.08117692774768752 0.02671275574632541 0.005511714091488045 0.03163781316341609 1.1067244248438782e-07 6.955960505289944 0.7309019697338811 TGEAIVDAALSALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGEAIVDAALSALR 14 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 78282100.0 38750000.0 21894100.0 17638000.0 False True 32222341.91606708 21776152.137661397 21326024.251102228 1.0 0.6758091076801317 0.661839673436908 24.941558016974593 TGEAIVDAALSALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGEAIVDAALSALR 14 0 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 74689100.0 2662300.0 32870800.0 39156000.0 False True 3446399.8317786953 31041511.084244553 32030009.774487942 1.0 9.006938428332024 9.293759092936462 21.71665865389993 -9.868584984920915 0.8082380694300256 6.703686751089e-19 9.232586724623614 0.9998368113302791 0.0491039614828067 1.1635388369586102 0.42401614639121116 3.2781228763698804 0.041056821255554946 1.3533652314662144e-10 9.868584984920915 9.232586724623614 TGEEIFGTIGMRPNAK(ub)NNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGEEIFGTIGMRPNAKNNR 19 2 E9PKG1;Q99873-2;Q99873-3;Q99873;Q99873-5 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 31817700.0 8252500.0 6553500.0 17011700.0 True False 7990528.904690121 9170346.726051023 12555825.429939358 1.0 1.1476520309773732 1.5713384657891156 22.92985956971389 -6.952446151455684 0.5313114228035316 0.9933801084084621 1.7448872735183742 0.9993795267296878 0.00603183792181503 0.0825181184226886 0.03201051087083695 0.006716471796112368 0.03504263260987893 1.115716481415783e-07 6.952446151455684 0.7515071651099121 TGEEIFGTIGMRPNAK(ub)NNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGEEIFGTIGMRPNAKNNR 19 2 E9PKG1;Q99873-2;Q99873-3;Q99873;Q99873-5 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 137121800.0 19013800.0 45032000.0 73076000.0 True False 28845324.694975782 36995687.76337805 58632496.569651335 1.0 1.2825540414118437 2.032651640765334 24.781834167277513 -6.954162676778608 0.5111084798892449 0.9863199458212412 2.361855757016017 0.999488749718866 0.009852529711323953 0.08185608521007434 0.029368901420171484 0.011326591883970836 0.06191201055418004 1.1113153759896732e-07 6.954162676778608 1.3755358111947755 up TGEEIFGTIGMRPNAK(ub)NNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGEEIFGTIGMRPNAKNNR 19 2 E9PKG1;Q99873-2;Q99873-3;Q99873;Q99873-5 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 35350900.0 5660800.0 8185100.0 21505000.0 True False 7753750.737367937 7823455.217493878 16425961.909377484 1.0 1.00898977572106 2.1184536962498988 22.88646292631895 -6.908673857235252 0.9046992703694432 0.9641910093555636 2.257848314369987 0.9904118084399086 0.05142115527801018 0.10530222500814748 0.1435654214497404 0.04182499701558559 0.11442487837043926 1.234031207572897e-07 6.908673857235252 1.2936573050144236 up TGEEIFGTIGMRPNAK(ub)NNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGEEIFGTIGMRPNAKNNR 19 2 E9PKG1;Q99873-2;Q99873-3;Q99873;Q99873-5 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 31999700.0 8252500.0 11646200.0 12101000.0 True False 6862319.3977379 11583459.609010309 14631263.151297685 1.0 1.6879802494807643 2.1321163156761176 22.710264845148167 -8.529206230695742 0.13158261512029917 4.355713079373691e-12 3.1168699777693143 0.9999355495933355 0.003739039043960523 0.1680933077812978 0.0334092346937395 0.39051296398025614 0.33759777134476376 2.956608147187466e-09 8.529206230695742 3.1168699777649587 TGEEIFGTIGMRPNAK(ub)NNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGEEIFGTIGMRPNAKNNR 19 2 E9PKG1;Q99873-2;Q99873-3;Q99873;Q99873-5 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 1 123807800.0 19013800.0 40218000.0 64576000.0 True False 24613738.91803094 37979832.945536695 52823830.605713904 1.0 1.5430338751872574 2.1461115997707076 24.552960489369962 -6.969771670663308 0.26358083161435986 0.8379189064762778 2.869203197862465 0.9999805472436308 0.002064613346589022 0.07637685809346466 0.009294825988216184 0.012304169874774276 0.05660124852734818 1.0720828021923717e-07 6.969771670663308 2.031284291386187 TGEEINFGK(ub)LITKPSEGTTLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGEEINFGKLITKPSEGTTLR 21 2 F8W7U8;P49959-2;P49959;P49959-3 F8W7U8 MRE11A Double-strand break repair protein MRE11A 1 19077000.0 4365300.0 11209000.0 3502700.0 True False 5722950.573625335 9536660.892339796 3140274.204270923 1.0 1.666388826821298 0.5487159401206647 22.448327716400897 -6.745200526672748 1.6675220807862663 1.3940947305774092 0.54727373271669 0.6280806919356728 0.27998069001053455 0.3085016941203363 1.6861780228069319 0.1327214137243304 0.32386286565480016 1.798040514676528e-07 6.745200526672748 -0.8468209978607192 TGEGFLCVFAINNTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGEGFLCVFAINNTK 15 0 P01116-2;P01116;P01112-2;P01112 P01116-2 KRAS;HRAS GTPase KRas;GTPase KRas, N-terminally processed;GTPase HRas;GTPase HRas, N-terminally processed 0 3707200.0 1060800.0 1440700.0 1205700.0 False True 1390719.0728018119 1225753.1758046146 1080945.7298910685 1.0 0.881380862444887 0.7772567091593426 20.407399592218184 -6.9726568592714395 0.18397421582590404 1.0763754529638776 0.5794351641027561 0.9999963701574384 0.00017327593947759427 0.07544962115112687 0.00582817259695365 0.0038721237515149673 0.011547224813417321 1.0649841412838382e-07 6.9726568592714395 -0.4969402888611215 TGEITASSNK(ub)SLNLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGEITASSNKSLNLLK 16 1 Q8TAT6;Q8TAT6-2;A0A0D9SFI9;I3L4U9 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 13728400.0 3908400.0 5823700.0 3996300.0 True False 5123950.248999445 4954826.660604802 3582801.2112164516 1.0 0.9669935147345219 0.6992263853295738 22.288825037222658 -6.929836592194253 0.7481316690720101 1.0040967250278596 0.6444831426844965 0.9965060274283637 0.007961035045649115 0.09272283018050827 0.07809639011254484 0.007245840179216359 0.024250130145666758 1.1753397055138386e-07 6.929836592194253 -0.35961358234336316 TGEITASSNK(ub)SLNLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGEITASSNKSLNLLK 16 1 Q8TAT6;Q8TAT6-2;A0A0D9SFI9;I3L4U9 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 18670900.0 4409200.0 8041100.0 6220600.0 True False 4269232.359474054 11251953.163782543 4591238.24600016 1.0 2.635591651228073 1.075424774154428 22.025545254921724 -6.635117955542686 2.0618914567764146 2.073527233949416 1.0818284366474538 0.13614173780559202 0.7006829030856692 0.5458661660102977 4.429012888896374 0.27730546402294604 0.776033532748211 2.316765324851374e-07 6.635117955542686 -0.9916987973019624 TGEITASSNK(ub)SLNLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGEITASSNKSLNLLK 16 1 Q8TAT6;Q8TAT6-2;A0A0D9SFI9;I3L4U9 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 34986500.0 5076700.0 9707800.0 20202000.0 True False 7701725.056484424 7975367.242612405 16209065.845148843 1.0 1.0355299863499527 2.104601985434641 22.87675019067687 -6.913968095650651 0.8682947051464542 0.9709066921240502 2.2551533135903448 0.9923343330927942 0.044875273133699246 0.10185209846347633 0.12497356528209191 0.037476509985901935 0.10652742641296835 1.219079152212302e-07 6.913968095650651 1.2842466214662944 up TGEITASSNK(ub)SLNLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGEITASSNKSLNLLK 16 1 Q8TAT6;Q8TAT6-2;A0A0D9SFI9;I3L4U9 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 10393100.0 3908400.0 3106900.0 3377800.0 True False 5353441.100538588 2969626.8848556206 2580033.207974668 1.0 0.5547136559617436 0.48193921620153835 22.35203509874555 -13.999999999999998 0.2549027670176127 4.174915268750119 0.45401276582900923 0.99955211751088 0.004846346546499399 14.197748754128723 0.1597586482233839 23.148448298782075 0.03269372910524159 1.0000000000000041e-14 13.999999999999998 -3.7209025029211102 TGEITASSNK(ub)SLNLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGEITASSNKSLNLLK 16 1 Q8TAT6;Q8TAT6-2;A0A0D9SFI9;I3L4U9 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 30613700.0 5076700.0 13778000.0 11759000.0 True False 6571888.226717839 13011242.188164609 9618982.657528952 1.0 1.9798331528627868 1.4636558513614444 22.64787651276932 -10.198793212102288 4.814162163860702 0.9998997131291673 1.7217445021143385 0.7227460105754995 0.21072850092182938 0.0002268554374280362 3.7755710210469604e-05 0.20406508721757166 0.0680123312190363 6.327130439119278e-11 10.198793212102288 0.7218447889851712 TGELYTWGWGK(ub)YGQLGHEDTTSLDRPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGELYTWGWGKYGQLGHEDTTSLDRPR 27 2 A6NED2;G3V2I3 A6NED2 RCCD1 RCC1 domain-containing protein 1 1 30726000.0 4305900.0 3140100.0 23280000.0 True False 4169211.5614305 4393958.30540518 17182269.61497018 1.0 1.053906293951072 4.121227565884127 21.991343151084898 -6.910711421108692 0.8908671599418293 0.907152981260224 4.52373129551968 0.99118748071804 0.13694684538419152 0.10394968999998558 0.13622603657481144 0.11251605547557005 0.3121513252089062 1.228255107888608e-07 6.910711421108692 3.6165783142594554 up TGELYTWGWGK(ub)YGQLGHEDTTSLDRPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGELYTWGWGKYGQLGHEDTTSLDRPR 27 2 A6NED2;G3V2I3 A6NED2 RCCD1 RCC1 domain-containing protein 1 1 27609100.0 4305900.0 4461200.0 18842000.0 True False 3580546.633713375 4437166.630121132 22781775.08443524 1.0 1.2392427983878427 6.362652805560118 21.771748426519174 -6.916647289242415 0.8492133320035733 0.8727276129086787 7.128351175623135 0.993197944747152 0.20400232440266605 0.1001850247877643 0.11613053227402216 0.17271673791323058 0.501894384291691 1.211581715979428e-07 6.916647289242415 6.255623562714456 up TGEMSGPVFTDSGIHIILR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TGEMSGPVFTDSGIHIILR 19 0 Q13526;K7EN45 Q13526 PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 27497420.0 9516020.0 11670300.0 6311100.0 False True 12475594.373268757 9929136.730473105 5658087.912345958 1.0 0.7958848639506986 0.4535325326438511 23.572605215560852 -6.963334770164813 0.38556463360244336 1.0220934618614026 0.21510977931052816 0.9998745973659234 0.0025247827867718366 0.07853066657640752 0.01688114613724455 0.004433193548423197 0.028853880879747495 1.0880910293868065e-07 6.963334770164813 -0.8069836825508745 down TGEMSGPVFTDSGIHIILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGEMSGPVFTDSGIHIILR 19 0 Q13526;K7EN45 Q13526 PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 30445500.0 15476200.0 8564600.0 6404700.0 False True 14984916.502243567 11984489.443798965 4727116.933118545 1.0 0.7997701850393779 0.31545834322205224 23.837007709215193 -6.956165437239072 0.48647330052173626 1.0109454973512493 0.08386837248797976 0.9996004919950173 0.005743913819636937 0.0811004123137094 0.026416974833524936 0.0069208228424610585 0.03994548447632015 1.1062023143860789e-07 6.956165437239072 -0.9270771248632695 down TGEMSGPVFTDSGIHIILR ddPTM_RPMI8226_Bortezomib_8h_R1 2 TGEMSGPVFTDSGIHIILR 19 0 Q13526;K7EN45 Q13526 PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 387955000.0 91102000.0 177100000.0 119753000.0 False True 138208394.44833153 145495121.31138438 96083767.0603956 1.0 1.0527227516978135 0.695209342702523 27.04227000334306 -6.869410514573982 1.1372749809653349 1.0297116000741813 0.6745106934501549 0.9640879286620132 0.029862819014214444 0.13741787871995909 0.3325649867702718 0.02038643559516544 0.04821466316971612 1.350795127557609e-07 6.869410514573982 -0.35520090662402637 TGEMSGPVFTDSGIHIILR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TGEMSGPVFTDSGIHIILR 19 0 Q13526;K7EN45 Q13526 PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 68891420.0 9516020.0 12618800.0 46756600.0 False True 13034349.754771039 12061259.691208655 35713654.06240409 1.0 0.9253441804255561 2.7399643813709704 23.635815277083744 -6.897305638219078 0.9781556388309177 0.9188765779224585 2.9203442569624176 0.9851771400195014 0.10207179965537129 0.11341541980067316 0.18882096018741715 0.0786444148880779 0.20198631778808843 1.2667600595517574e-07 6.897305638219078 2.0014676790399593 up TGEMSGPVFTDSGIHIILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGEMSGPVFTDSGIHIILR 19 0 Q13526;K7EN45 Q13526 PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 26804900.0 15476200.0 4534800.0 6793900.0 False True 12869146.01190804 4510370.132312675 8214473.0785555905 1.0 0.3504793657744774 0.6383075513289381 23.61741298464947 -10.450013595329871 6.134466780567127 1.0002137663564357 0.49439345855181227 0.8044703661907703 0.11750536469992434 0.000343680750389273 3.0812655605738076e-05 0.11382113684033078 0.03792469338106961 3.548022821857821e-11 10.450013595329871 -0.5058203078046234 TGEMSGPVFTDSGIHIILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGEMSGPVFTDSGIHIILR 19 0 Q13526;K7EN45 Q13526 PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 155799000.0 47916000.0 62245000.0 45638000.0 False True 62028206.56556664 58781011.032247484 37332352.28542448 1.0 0.9476496949837374 0.6018609009106605 25.886421076782536 -6.933836806794705 0.7145973654391228 1.004584311420776 0.5233992597698103 0.997240020204004 0.009280035575288004 0.09069408673847992 0.06827564803648317 0.008656516906981472 0.030654706781834355 1.1645635508712819e-07 6.933836806794705 -0.4811850516509657 TGESILSLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGESILSLLR 10 0 H7C0X4;Q92685;C9J7S5;Q92685-2 H7C0X4 ALG3 Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase 0 2855380.0 325480.0 1003300.0 1526600.0 False True 426707.4319528033 853611.55083277 1368642.0761812276 1.0 2.0004609409455636 3.207448414755074 18.702887712578555 -6.96862357694375 0.28917703184101184 0.761829354002914 4.483328254268907 0.99996956793576 0.004978666239194236 0.0767518845171932 0.010620637097902523 0.021180433387148704 0.10955966913549647 1.0749206920283693e-07 6.96862357694375 3.721498900265993 TGFFEFQAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGFFEFQAAK 10 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;Q9P2J5-3 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 16422900.0 3973600.0 5312200.0 7137100.0 False True 5209428.080397144 4519640.466793417 6398621.355897442 1.0 0.8675886099283396 1.22827712699887 22.312693563542837 -6.807369781665996 1.425829381857231 0.9276095662561089 1.2341984771698955 0.8527733303220596 0.05716153594094938 0.21041550324083502 0.8436239461710565 0.031529302473244446 0.0730154897001215 1.5582251811540133e-07 6.807369781665996 0.3065889109137866 TGFFEFQAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGFFEFQAAK 10 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;Q9P2J5-3 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 8281500.0 2146200.0 1755300.0 4380000.0 False True 2078070.0557704824 2456200.4437685744 3232746.6028165612 1.0 1.1819622908997134 1.5556485181236883 20.98681286043301 -6.959523865872946 0.4420939930321536 0.9869265664657394 1.765304471976961 0.9997521273555119 0.003641575082665099 0.07987166072296077 0.02176318004573055 0.004939941581826036 0.030950239328849258 1.0976809675309239e-07 6.959523865872946 0.7783779055112217 TGFFEFQAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGFFEFQAAK 10 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;Q9P2J5-3 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 13145300.0 3973600.0 4143400.0 5028300.0 False True 5442747.302502338 3960330.88760848 3840719.10108918 1.0 0.7276345322494934 0.7056581699693066 22.375903625065728 -13.999999999999998 0.3567593627285156 4.4925806299047535 0.7028881535566573 0.9997673717208791 0.002041876706516874 21.35076723285395 0.19277245385153535 56.69090636422434 0.006409379345161932 1.0000000000000041e-14 13.999999999999998 -3.789692476348096 TGFFEFQAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGFFEFQAAK 10 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;Q9P2J5-3 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 7485300.0 2146200.0 2509100.0 2830000.0 False True 1784660.3927809817 2495582.980282645 3421739.915558416 1.0 1.398351748252705 1.9173059083955033 20.767218135867285 -6.967494067187364 0.3122981563869735 0.9221898140005084 2.4100189568128925 0.9999557134459377 0.002499314632039366 0.07712450483057781 0.011926452939930653 0.00812704991811283 0.045971790122682606 1.0777199761172068e-07 6.967494067187364 1.4878291428123842 TGFFEFQAAK(ub)DK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGFFEFQAAKDK 12 1 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;Q9P2J5-3 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 1 7523900.0 1429000.0 2448500.0 3646400.0 True False 1383637.1771950528 3426198.8187588155 2691298.450344814 1.0 2.4762263368092636 1.9450897205585989 20.400034252699808 -9.891970791849378 5.705545603969611 0.9999994231425305 2.210658028686173 0.8738549720464907 0.21683561559502382 1.591139568873844e-06 3.087080796819928e-07 0.20995028211216132 0.06998339400419178 1.2824168277405945e-10 9.891970791849378 1.2106586055436424 TGFFEFQAAK(ub)DK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGFFEFQAAKDK 12 1 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;Q9P2J5-3 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 1 5386900.0 1917400.0 1183900.0 2285600.0 True False 2626314.595786683 1131591.3833662397 1745788.3534095902 1.0 0.4308666544296017 0.6647293344865485 21.3246083106109 -10.283720420298746 5.669308663134256 1.00003931175728 0.5477979944580741 0.8329209724263082 0.09547403933656672 4.744353667332239e-05 5.994374378806664e-06 0.0924503524080935 0.03081411369546986 5.203308548754921e-11 10.283720420298746 -0.4522413172992058 TGFFEFQAAK(ub)DK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGFFEFQAAKDK 12 1 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;Q9P2J5-3 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 1 6349900.0 1429000.0 1960200.0 2960700.0 True False 1188276.8154338019 1949640.013530764 3579768.681269898 1.0 1.6407288168952558 3.0125713426151792 20.180439528134084 -6.958690102506403 0.45351675479641557 0.9573169543453295 3.750687766772262 0.9997184917640153 0.014085399773529964 0.08017239372460863 0.02288552791730285 0.01843483763332402 0.11341755607074527 1.0997903317780023e-07 6.958690102506403 2.7933708124269323 TGFINLDKPSNPSSHEVVAWIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGFINLDKPSNPSSHEVVAWIR 22 1 O60832;O60832-2;C9IYT0;H7C0M1;H7C2Q9 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 0 8659000.0 2211700.0 3616800.0 2830500.0 False True 2899560.118133265 3077187.5381759754 2537627.0120732137 1.0 1.0612601266419222 0.8751765470229106 21.46740262007373 -6.817992835082112 1.3804180223494618 1.0330879261077794 0.8712825895795212 0.8797277631308797 0.026853481856284386 0.19610439068081634 0.7347935863041841 0.015288428831513705 0.03525965176203476 1.520572615678825e-07 6.817992835082112 -0.16180533652825824 TGFINLDKPSNPSSHEVVAWIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGFINLDKPSNPSSHEVVAWIR 22 1 O60832;O60832-2;C9IYT0;H7C0M1;H7C2Q9 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 0 19266100.0 5335700.0 4275300.0 9655100.0 False True 5166321.124114516 5982449.58539497 7126139.663208709 1.0 1.157970912313418 1.3793450875413977 22.300705889467853 -6.966363033501496 0.33383390038907157 0.9742072485331207 1.5703974776072003 0.9999385453878674 0.0012196743409615717 0.07750143712153304 0.013245500041751245 0.0031875516577679398 0.019250241439973583 1.0805303415879851e-07 6.966363033501496 0.5961902290740796 TGFINLDKPSNPSSHEVVAWIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGFINLDKPSNPSSHEVVAWIR 22 1 O60832;O60832-2;C9IYT0;H7C0M1;H7C2Q9 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 0 14797600.0 2211700.0 5627100.0 6958800.0 False True 3029425.2589451377 5378476.1156687 5315274.760984711 1.0 1.775411391909208 1.7545489017397045 21.530612681596622 -10.434268211420658 4.82793772608172 0.9985798580632348 1.7649801468245672 0.999442491832285 0.008517075947072288 0.0001304013257334981 1.5280270092721778e-05 0.008259847457091784 0.00274887444170418 3.67901694879844e-11 10.434268211420658 0.7664002887613324 TGFINLDKPSNPSSHEVVAWIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGFINLDKPSNPSSHEVVAWIR 22 1 O60832;O60832-2;C9IYT0;H7C0M1;H7C2Q9 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 0 26916100.0 10045000.0 8818000.0 8053100.0 False True 13003450.51655223 8327270.548355029 6587518.431783855 1.0 0.6403892980370985 0.506597723688688 23.632391163048986 -13.999999999999998 0.13730842565765428 2.71415778944099 0.33552895902889146 0.9996138792499693 0.0040939506943437716 11.93219301768856 0.11589259042074795 5.489155919209404 0.1526731632452737 1.0000000000000041e-14 13.999999999999998 -2.3786288304120986 TGFQAVTGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGFQAVTGKR 10 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 3008150.0 817650.0 989300.0 1201200.0 True False 1071947.0681338627 841700.2962611963 1076911.3467240212 1.0 0.7852069577712454 1.004631085561716 20.031802237782024 -11.050588368764277 9.87980911018193 1.3321448585294333 0.8949190216664807 0.23417797281421715 0.08957952505698384 0.04842037430908038 0.0002479309102570755 0.006408210774286319 0.02891166739223904 8.900443163930946e-12 11.050588368764277 -0.4372258368629526 TGFQAVTGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGFQAVTGKR 10 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 7630290.0 692790.0 3759500.0 3178000.0 True False 670797.760664073 5260687.955533498 2345586.4620436104 1.0 7.842435177967124 3.4967118252176905 19.355518347172957 -9.522064746854458 10.309551577573735 1.0002133744135588 5.669573501592362 0.6062158266779443 1.7741341338659198 0.0 2.7412045889873028e-17 1.7177979610758947 0.5725993288892063 3.00562817472155e-10 9.522064746854458 4.669360127178804 TGFQAVTGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGFQAVTGKR 10 1 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 1 6259030.0 692790.0 4972900.0 593340.0 True False 576085.5808008281 4946110.000656631 717404.6507058055 1.0 8.585720881576215 1.2453091599837076 19.135923622607233 -6.638541557503124 2.0502162853988604 5.966174096432485 1.2760032160245995 0.14892974854060814 3.246905394482367 0.5369991312974106 4.312401637429264 1.290639208095641 3.594361053147029 2.2985737489371846e-07 6.638541557503124 -4.690170880407885 TGFSTSPESPYTHWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGFSTSPESPYTHWK 15 0 E9PKG1;Q99873-2;Q99873-3;Q99873;Q99873-5 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 0 14193100.0 2202300.0 6251400.0 5739400.0 False True 2887236.62710354 5318715.487766341 5145541.944212324 1.0 1.842147414533892 1.782168422189318 21.4612579196273 -10.17362842610411 4.7679321429499835 0.9999073038034527 1.8121579183646215 0.9959261429520949 0.024486321104710062 2.4269498522518453e-05 4.206396862954153e-06 0.023711474578013068 0.007902926151706196 6.704579948884606e-11 10.17362842610411 0.8122506145611688 TGFSTSPESPYTHWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGFSTSPESPYTHWK 15 0 E9PKG1;Q99873-2;Q99873-3;Q99873;Q99873-5 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 0 10667800.0 2202300.0 4325300.0 4140200.0 False True 3016549.824919694 4134193.9441456227 3162370.0300955484 1.0 1.370504113670883 1.0483400618717564 21.52446798115019 -10.382924313579888 6.023890246318341 0.9999598369879557 1.2094220877713198 0.36037517127252106 0.13152292339590524 7.095610104571622e-05 7.268587620869936e-06 0.1273709045501549 0.04244884099640451 4.140718306613302e-11 10.382924313579888 0.2094622507833641 TGFSTSPESPYTHWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGFSTSPESPYTHWK 15 0 E9PKG1;Q99873-2;Q99873-3;Q99873;Q99873-5 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 0 2346600.0 2346600.0 0.0 0.0 False True 1951301.8720062715 0.0 0.0 1.0 0.0 0.0 20.896005553605008 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 TGGADQSLQQGEGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGGADQSLQQGEGSK 15 0 A0A087WYR0;P09132 A0A087WYR0 SRP19 Signal recognition particle 19 kDa protein 0 2518960.0 323460.0 1043400.0 1152100.0 False True 424059.19239109603 887728.7871413439 1032891.7437235636 1.0 2.0934077201246484 2.4357253946070836 18.69390613217049 -10.242233029210107 0.26523598747083227 1.1134153317538356e-11 2.5953333253157194 0.9990675459719524 0.018696781829988716 1.7538600711501273 0.12512452929920323 1.3808565832529178 0.14304241636203258 5.7248876849817515e-11 10.242233029210107 2.595333325304585 TGGADQSLQQGEGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGGADQSLQQGEGSK 15 0 A0A087WYR0;P09132 A0A087WYR0 SRP19 Signal recognition particle 19 kDa protein 0 2560160.0 323460.0 1036500.0 1200200.0 False True 443051.903177825 990704.0027528575 916737.4788949012 1.0 2.2360901638091484 2.069142401419628 18.75711619369338 -10.651783350237396 6.68580945813336 0.9945852977521302 2.152616282614388 0.9845092385294804 0.0681561385922889 0.005488529343932711 0.0002858583691156991 0.06584324055935784 0.021997299142478294 2.2295470915288126e-11 10.651783350237396 1.1580309848622576 TGGADQSLQQGEGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGGADQSLQQGEGSK 15 0 A0A087WYR0;P09132 A0A087WYR0 SRP19 Signal recognition particle 19 kDa protein 0 2084650.0 885240.0 457490.0 741920.0 False True 1145960.6306891697 432030.2793339697 606898.1727420599 1.0 0.3770027239715476 0.5295977509952302 20.128126050692003 -10.305788196933591 8.596374008720623 1.0000005889041068 0.4533002374841541 0.9447945881118688 0.062296658915705405 7.030385639237488e-07 5.687940360132381e-08 0.06031854533271869 0.020106160208740908 4.945518184258468e-11 10.305788196933591 -0.5467003514199527 TGGAYGEDLGADYNLSQVCDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGGAYGEDLGADYNLSQVCDGK 22 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 13545800.0 2178000.0 6379900.0 4987900.0 False True 2855379.0917820027 5428043.788655422 4471799.955315312 1.0 1.9009888404232358 1.566096763888722 21.445250865709866 -10.0318097099523 4.986921706459274 0.9999910650916447 1.7335428021585935 0.8648110165274621 0.13671911776185486 94525790.61877224 3.8357962477423104 11823.07173935999 0.04680259052113826 9.29373510974306e-11 10.0318097099523 0.7335517370669488 TGGAYGEDLGADYNLSQVCDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGGAYGEDLGADYNLSQVCDGK 22 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 11388400.0 2178000.0 4147200.0 5063200.0 False True 2983265.458236883 3963962.991043556 3867376.4398772446 1.0 1.3287329091344984 1.296356792252364 21.508460927232758 -10.065620682533584 4.468614870981281 0.9999792849983427 1.312544850716513 0.992016285914117 0.013217494444353 9169200.75353234 0.17365949562616234 1969.0139073263 0.004524699901831347 8.597641208871119e-11 10.065620682533584 0.3125655657181703 TGGLEIDSDFGGFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGGLEIDSDFGGFR 14 0 O95831-3;O95831;E9PMA0;O95831-2;O95831-5 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 0 10212600.0 4242600.0 2020700.0 3949300.0 False True 4107920.9852818293 2827576.0478112884 2914859.8535395963 1.0 0.6883228908107392 0.7095705745030582 21.96997700140911 -10.514968696857562 6.188142043611888 1.0003000549153394 0.6989467326568988 0.9962779818788098 0.008674330543706176 3.594375165027238e-05 2.817310895321041e-06 0.00840710121440088 0.002799628144606027 3.055141314210875e-11 10.514968696857562 -0.3013533222584406 TGGLEIDSDFGGFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGGLEIDSDFGGFR 14 0 O95831-3;O95831;E9PMA0;O95831-2;O95831-5 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 0 20871600.0 2470700.0 11649000.0 6751900.0 False True 3748232.532364739 9570144.935947575 5417384.0055371 1.0 2.5532420556389077 1.4453169483909534 21.837779026825867 -10.344697075897244 5.874946779023272 0.9998588056964166 1.9992795020149325 0.5203044702564608 0.4523085309959763 0.0008365989143356137 9.331615852610271e-05 0.4380061154776247 0.14598195065791214 4.5217122769105166e-11 10.344697075897244 0.9994206963185159 TGGLEIDSDFGGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGGLEIDSDFGGFR 14 0 O95831-3;O95831;E9PMA0;O95831-2;O95831-5 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 0 7782000.0 2470700.0 0.0 5311300.0 False True 3198369.854778059 0.0 4344697.898540141 1.0 0.0 1.3584100950831492 21.608905348918316 -6.709471825298813 1.7972426399226287 0.3848755706545353 1.3551443210214444 0.4624812232124683 0.42143126766050126 0.3761596679334557 2.36819336649173 0.18663246586770718 0.47441058247348783 1.9522173793484864e-07 6.709471825298813 0.9702687503669092 TGGTQTDLFTCGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGGTQTDLFTCGK 13 0 A0A1W2PPZ5;P23193;A0A1W2PRL9;P23193-2;B7Z4S1;Q5JRI7;A0A0A0MT58;Q15560-2;Q15560 A0A1W2PPZ5 TCEA1;TCEA2 Transcription elongation factor A protein 1;Transcription elongation factor A protein 2 0 5442800.0 0.0 2560500.0 2882300.0 False True 0.0 2178483.38075083 2584067.2449738984 0.0 TGGTQTDLFTCGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGGTQTDLFTCGK 13 0 A0A1W2PPZ5;P23193;A0A1W2PRL9;P23193-2;B7Z4S1;Q5JRI7;A0A0A0MT58;Q15560-2;Q15560 A0A1W2PPZ5 TCEA1;TCEA2 Transcription elongation factor A protein 1;Transcription elongation factor A protein 2 0 3672000.0 0.0 2018200.0 1653800.0 False True 0.0 1929029.2507050824 1263206.5010801437 0.0 TGGTQTDLFTCGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGGTQTDLFTCGK 13 0 A0A1W2PPZ5;P23193;A0A1W2PRL9;P23193-2;B7Z4S1;Q5JRI7;A0A0A0MT58;Q15560-2;Q15560 A0A1W2PPZ5 TCEA1;TCEA2 Transcription elongation factor A protein 1;Transcription elongation factor A protein 2 0 8438600.0 2743900.0 2064600.0 3630100.0 False True 3552032.6403551702 1949703.1950707396 2969459.0479714153 1.0 0.5488978825588121 0.8359886714539022 21.76021340829321 -10.421716918189519 6.3925504841200755 1.0000618331583595 0.6924432770063575 0.6047756857036466 0.11720432377434237 0.00010330654460973669 9.345367353754029e-06 0.11350531905034872 0.03782753284012749 3.786893415581371e-11 10.421716918189519 -0.30761855615200195 TGHSK(ub)GFGFVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGHSKGFGFVR 11 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 20346600.0 5217900.0 8395700.0 6733000.0 True False 6840717.4302154835 7143094.286182269 6036333.747496528 1.0 1.0442025063966516 0.8824123798527346 22.705716207116176 -6.833901658191862 1.310425246578022 1.0235624445557698 0.8777025198457656 0.9134484155854472 0.02008709743638468 0.1760449649257458 0.5898450863841331 0.012030430329351416 0.027686471799353546 1.465879737744031e-07 6.833901658191862 -0.1458599247100042 TGHSK(ub)GFGFVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGHSKGFGFVR 11 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 75007200.0 9092200.0 13927000.0 51988000.0 True False 13793532.128856875 11441618.037852347 41712549.01285014 1.0 0.8294915276933175 3.024065817455491 23.71748860128733 -6.888129662788364 1.033357212105795 0.876742124115447 3.206063246790957 0.9796748851209152 0.14210662586871736 0.12067485138133915 0.23080388244723227 0.10502872889428957 0.2601422285678629 1.2938095045277473e-07 6.888129662788364 2.32932112267551 up TGHSK(ub)GFGFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGHSKGFGFVR 11 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 19163500.0 5217900.0 6442400.0 7503200.0 True False 7147098.638445474 6157753.46583213 5731098.693254653 1.0 0.8615738745661791 0.8018776545808514 22.768926268639067 -13.999999999407589 0.11465996874812881 1.663269978899544 0.6993637452722428 0.9997194900923944 0.0013898486561301161 11.987315870684954 0.1034837764127117 1.8258846337477401 0.0909787263069012 1.0000000013640778e-14 13.999999999407589 -0.9639062336273012 TGHSLLHTLYGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGHSLLHTLYGR 12 0 P31040-2;P31040;D6RFM5;A0A494C1T6 P31040-2 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0 68104000.0 17000000.0 18119000.0 32985000.0 False True 22287164.628234174 15415715.827308834 29572028.614462078 1.0 0.6916858238566451 1.3268636503451487 24.409709752905385 -6.774655586081819 1.5561877803726871 0.8242241696440414 1.331125967216706 0.7482679799556093 0.13012197796529806 0.2589296416470398 1.238022812332147 0.06587869033439982 0.15618731092608465 1.6801359088657822e-07 6.774655586081819 0.5069017975726645 TGHSLLHTLYGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGHSLLHTLYGR 12 0 P31040-2;P31040;D6RFM5;A0A494C1T6 P31040-2 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0 49766800.0 12845000.0 8188800.0 28733000.0 False True 12437242.505997514 11458630.54402787 21206965.328476734 1.0 0.9213160022008307 1.7051179405925603 23.56816332139217 -6.882190992298471 1.067546296576072 0.9496692757675076 1.7630436499968933 0.9754084589492302 0.0552636636963005 0.12570510475116675 0.2607309449448702 0.039796639674150286 0.09679371878287062 1.3116229518441027e-07 6.882190992298471 0.8133743742293857 TGHSLLHTLYGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGHSLLHTLYGR 12 0 P31040-2;P31040;D6RFM5;A0A494C1T6 P31040-2 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0 23016000.0 8212100.0 10781000.0 4022900.0 False True 12458356.084928373 8857046.317662543 3227772.051700289 1.0 0.7109321853769653 0.2590849089315339 23.57061037747002 -7.129881326567471 0.4025616309488856 1.0271069617584827 7.894797022528996e-12 0.9997841844557702 0.004479193103096411 0.07940335353691359 0.02140697564901853 0.0072857750887062745 0.038996614750236566 7.415128362113749e-08 7.129881326567471 -1.027106961750588 down TGHSLLHTLYGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGHSLLHTLYGR 12 0 P31040-2;P31040;D6RFM5;A0A494C1T6 P31040-2 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0 45435000.0 17000000.0 16510000.0 11925000.0 False True 23285359.407725897 15780533.608731009 9108560.603084251 1.0 0.6777019556543823 0.3911711407839427 24.472919814428277 -7.290257031481899 0.22074856614964547 1.1515249351183663 1.4703307784977432e-15 0.999968350923567 0.0013990914302865255 0.10497937334407681 0.013551223951536046 0.01711186174817295 0.04620638476212057 5.125579435234236e-08 7.290257031481899 -1.1515249351183647 down TGHSLLHTLYGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGHSLLHTLYGR 12 0 P31040-2;P31040;D6RFM5;A0A494C1T6 P31040-2 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0 28725600.0 12845000.0 8347500.0 7533100.0 False True 10681186.629984032 8302530.360650981 9108236.380880952 1.0 0.777304118752524 0.8527363762479795 23.348568596826446 -10.528062011790169 8.716179071013261 1.0000142438758068 0.8150202475002517 0.8891122219428843 0.030795090168349606 8.524540968585125e-06 4.6155180392085523e-07 0.02981951130737636 0.009939072613914492 2.9644080791111464e-11 10.528062011790169 -0.18499399637555514 TGHSLLHTLYGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGHSLLHTLYGR 12 0 P31040-2;P31040;D6RFM5;A0A494C1T6 P31040-2 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0 24617200.0 8212100.0 10632000.0 5773100.0 False True 10630725.334691765 10040319.853720868 4722455.0370082855 1.0 0.9444623520613219 0.4442269824804209 23.34173669956247 -6.927959462955663 0.7633558265138639 1.0082106620049556 0.34667150933059376 0.9961217827629361 0.015564728696650184 0.09371129271335367 0.08297299929820119 0.014011766158171466 0.04578105035011502 1.1804308119146314e-07 6.927959462955663 -0.6615391526743618 down TGHYTLIHDHSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGHYTLIHDHSK 12 0 Q8N543;A0A0A0MTR2;Q8N543-2 Q8N543 OGFOD1 Prolyl 3-hydroxylase OGFOD1 0 4076430.0 1310600.0 926530.0 1839300.0 False True 1268995.7203861708 1296498.2607901187 1357532.152182761 1.0 1.0216726817609587 1.0697688970689734 20.27525577310677 -6.957961100994496 0.4632771283553147 0.9986430308283764 1.094748084010373 0.9996868986532258 0.000515873469777132 0.080437674764106 0.023884684040194715 0.0006569160907594058 0.003971887398978698 1.101637976930601e-07 6.957961100994496 0.09610505318199658 TGHYTLIHDHSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGHYTLIHDHSK 12 0 Q8N543;A0A0A0MTR2;Q8N543-2 Q8N543 OGFOD1 Prolyl 3-hydroxylase OGFOD1 0 3230860.0 1310600.0 1442000.0 478260.0 False True 1089821.9694244522 1434231.6597854118 578261.954775607 1.0 1.3160238094143455 0.5306022185265672 20.055661048541047 -6.797512416729187 1.4662653465815891 1.1749155889456597 0.5204382679757651 0.8247410951711567 0.135085893514913 0.22432033124357556 0.9523994566029768 0.07249050591551855 0.16883184843904656 1.5939973067603334e-07 6.797512416729187 -0.6544773209698946 TGICICFYQPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGICICFYQPR 11 0 A0A087WVC1;Q9BQ39 A0A087WVC1 DDX50 ATP-dependent RNA helicase DDX50 0 7986600.0 2757900.0 2976100.0 2252600.0 False True 3615633.6075415947 2532077.480746941 2019522.5604649796 1.0 0.7003136256576052 0.5585528788792649 21.785817058093734 -13.999999999857883 0.09957572180196951 2.4818731756092114 0.25462176916219936 0.999795840677689 0.002629408718233092 12.083690676814065 0.09388899221827063 3.683644980410821 0.27113325393824805 1.0000000003272375e-14 13.999999999857883 -2.227251406447012 TGICICFYQPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGICICFYQPR 11 0 A0A087WVC1;Q9BQ39 A0A087WVC1 DDX50 ATP-dependent RNA helicase DDX50 0 35167000.0 12637000.0 0.0 22530000.0 False True 19171252.888449922 0.0 18076935.624750197 1.0 0.0 0.9429188446854708 24.192441287961927 -10.064646995722669 13.294665499377361 0.9999991981293581 0.4714594223427354 0.2952461450461277 0.38494500638928264 0.0 0.0 0.37272139973772406 0.12424046657924133 8.616938716790783e-11 10.064646995722669 -0.5285397757866227 TGICICFYQPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGICICFYQPR 11 0 A0A087WVC1;Q9BQ39 A0A087WVC1 DDX50 ATP-dependent RNA helicase DDX50 0 12779600.0 2757900.0 4020500.0 6001200.0 False True 3777570.159445137 3842861.0159844286 4583840.158593637 1.0 1.0172838236706323 1.2134361415187926 21.849027119616625 -6.924213059453888 0.7928385143905193 0.9962932541957452 1.2483519998278747 0.995273774458227 0.006654653313985408 0.0957557437635823 0.09322558192012811 0.005865565767609966 0.018345386288553207 1.1906577428903368e-07 6.924213059453888 0.2520587456321295 TGICICFYQPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGICICFYQPR 11 0 A0A087WVC1;Q9BQ39 A0A087WVC1 DDX50 ATP-dependent RNA helicase DDX50 0 43670000.0 12637000.0 18358000.0 12675000.0 False True 16358845.612510763 17336361.162021026 10368280.056482645 1.0 1.059754555588121 0.6338026717822491 23.963567610054376 -6.87138435908191 1.1266954634934359 1.034098057498979 0.608186055326596 0.9660479748405286 0.03469597792652969 0.13553703786772117 0.32072001060462063 0.023877537498694288 0.05667312819899881 1.3446697683321085e-07 6.87138435908191 -0.4259120021723831 TGIDLGTTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGIDLGTTGR 10 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;A0A0U1RQW2;A0A087X122 Q14498-3 RBM39 RNA-binding protein 39 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 TGIDLGTTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGIDLGTTGR 10 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;A0A0U1RQW2;A0A087X122 Q14498-3 RBM39 RNA-binding protein 39 0 9125200.0 3141100.0 1252300.0 4731800.0 False True 3041387.499851208 1752349.9206582254 3492399.629042786 1.0 0.5761679236019595 1.148291570611651 21.536298209599025 -6.7082563384522045 1.8011570145783873 0.7389818090725002 1.1468959898061315 0.4569619226897942 0.1786491633010021 0.3785781985278968 2.392952784969547 0.07895933483176334 0.20103887537061235 1.9576888240219984e-07 6.7082563384522045 0.4079141807336313 TGIDLGTTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGIDLGTTGR 10 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;A0A0U1RQW2;A0A087X122 Q14498-3 RBM39 RNA-binding protein 39 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 TGIDLGTTGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGIDLGTTGR 10 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;A0A0U1RQW2;A0A087X122 Q14498-3 RBM39 RNA-binding protein 39 0 4958000.0 3141100.0 1816900.0 0.0 False True 2611963.824324081 1807111.9990735864 0.0 1.0 0.6918595051909753 0.0 21.3167034850333 -7.4451058358599616 0.7393066753753197 0.9914979246170932 1.1696820454168082e-17 0.9872392595739934 0.04723529498710319 0.11622832175802568 0.1403701490264188 0.04124464749804103 0.0742839996797875 3.588344774357786e-08 7.4451058358599616 -0.9914979246170932 down TGIEQGSDAGYLCESQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGIEQGSDAGYLCESQK 17 0 H0YFD6;P40939;A0A2R8Y4F5;A0A2R8YG21 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 11387400.0 2008400.0 5151600.0 4227400.0 False True 2633031.849373268 4383001.360779526 3789989.200084191 1.0 1.6646214749824608 1.4394011986548167 21.328293541773462 -10.151423069529782 4.724603766204335 0.9999498731362326 1.5520113368189938 0.8890093092748594 0.09194579283181382 64328078.266993545 3.8430285721042874 37821.40973551905 0.03147549049428577 7.056298275101066e-11 10.151423069529782 0.5520614636827612 TGIEQGSDAGYLCESQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGIEQGSDAGYLCESQK 17 0 H0YFD6;P40939;A0A2R8Y4F5;A0A2R8YG21 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 10186300.0 2008400.0 4282400.0 3895500.0 False True 2750959.754969219 4093189.4079969507 2975463.130340853 1.0 1.4879132275938183 1.081609109317612 21.391503603296353 -10.021489355013024 5.887556205362256 0.9999995063215199 1.284761168455756 0.39574645155840316 0.16587296169483423 1.074879038628827e-06 1.784482553605641e-07 0.16060608216330538 0.05353526818582819 9.517231755026978e-11 10.021489355013024 0.28476166213423615 TGIEQGSDAGYLCESQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGIEQGSDAGYLCESQK 17 0 H0YFD6;P40939;A0A2R8Y4F5;A0A2R8YG21 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 6969400.0 2493200.0 2621000.0 1855200.0 False True 3227496.548319366 2475139.0459558307 1517572.6359594953 1.0 0.7668913068999855 0.4702011646611153 21.621984121951854 -6.967843243407498 0.305339588132329 1.0482974797757258 0.1794272298336562 0.999960335295224 0.0013654430795091662 0.07700891121853655 0.011521943012675145 0.004796483269658794 0.026462182460061653 1.0768538289197827e-07 6.967843243407498 -0.8688702499420696 down TGIQEMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGIQEMR 7 0 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 0 4039610.0 656810.0 1608800.0 1774000.0 False True 861084.2705570882 1368773.311053282 1590443.4974096038 1.0 1.5895927470231674 1.8470242132987151 19.715794909231427 -10.679397322894504 0.1692817383860356 1.3379569312429142e-17 2.1355915366957547 0.999558339571045 0.0074510854409533585 2.5872046965185973 0.09140131350304358 1.2528272094532344 0.20098405507452682 2.0921974917666452e-11 10.679397322894504 2.1355915366957547 TGIQEMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGIQEMR 7 0 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 0 5509400.0 1436300.0 1282300.0 2790800.0 False True 1390705.4426908721 1794329.077106161 2059805.7577946212 1.0 1.2902294202820683 1.4811229571440439 20.4073854526337 -8.668371323647339 0.06906808308565787 1.6225498794093502e-08 2.449142889202472 0.999993898401406 0.0004885801173027673 0.24094349894956546 0.01863725276477368 0.34325277624829104 0.3030985657448788 2.145994854693214e-09 8.668371323647339 2.449142872976973 TGIQEMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGIQEMR 7 0 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 0 4950310.0 656810.0 2578200.0 1715300.0 False True 899650.4066228503 2464286.5990327224 1310181.467712403 1.0 2.7391602125577603 1.4563228761610005 19.77900497075432 -6.568149090583534 2.3140569262422 2.1926665060017942 1.4588797928277908 0.0 0.7578100265688623 0.7357321153319667 7.393526170065737 0.27709282213150743 0.8499196848279453 2.703030271401589e-07 6.568149090583534 -0.7337867131740035 TGIQEMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGIQEMR 7 0 Q13435;E9PPJ0 Q13435 SF3B2 Splicing factor 3B subunit 2 0 4120480.0 1544100.0 915280.0 1661100.0 False True 1998867.888761405 864343.8634042176 1358796.8443253117 1.0 0.43241670360706375 0.6797832172726972 20.93075169246866 -10.352245690116781 5.869369123915656 1.0000700448222317 0.5560999604398855 0.8110946525160192 0.10098695632200347 9.257688299620745e-05 1.0216985300376924e-05 0.09779553991326206 0.03259340000160751 4.443798007380726e-11 10.352245690116781 -0.4439700843823462 TGISDVFAK(ub)NDLAVVDVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGISDVFAKNDLAVVDVR 18 1 P19338 P19338 NCL Nucleolin 1 32964100.0 7622900.0 17387000.0 7954200.0 True False 9993695.720268618 14792927.373995163 7131175.6860740995 1.0 1.4802259132217752 0.7135674214706251 23.252586862088556 -6.7373551899167765 1.696371248331846 1.2866043724455758 0.7133715517410294 0.5930127958873275 0.2017869546832507 0.3226234688319607 1.821879041905329 0.09414292007735214 0.23169311188031125 1.8308164674839163e-07 6.7373551899167765 -0.5732328207045464 TGISDVFAK(ub)NDLAVVDVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGISDVFAKNDLAVVDVR 18 1 P19338 P19338 NCL Nucleolin 1 106385600.0 30990000.0 40392600.0 35003000.0 True False 30006239.41306839 56521575.824626245 25834664.232508697 1.0 1.883660762901526 0.8609764081685332 24.83875918607757 -6.678097553488127 1.9082894789864715 1.560035294114359 0.8648885259307595 0.3156277954972696 0.37466979150884333 0.44274378469178777 3.1154163880431582 0.1576266673894382 0.4168002497431479 2.098468461765171e-07 6.678097553488127 -0.6951467681835994 TGISDVFAK(ub)NDLAVVDVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGISDVFAKNDLAVVDVR 18 1 P19338 P19338 NCL Nucleolin 1 159088200.0 35720000.0 45276200.0 78092000.0 True False 54189851.48179404 37196308.365434825 62657081.97106046 1.0 0.6864072764239173 1.1562512215430436 25.69151935734447 -6.726827854580787 1.7348617272083247 0.81061387859298 1.1558092097176396 0.5444307893825862 0.13186345933825352 0.34223686730460806 2.016461730172565 0.060270908256116806 0.1500945509264505 1.8757378647241598e-07 6.726827854580787 0.3451953311246596 TGISDVFAK(ub)NDLAVVDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGISDVFAKNDLAVVDVR 18 1 P19338 P19338 NCL Nucleolin 1 41610900.0 7622900.0 14970000.0 19018000.0 True False 10441292.131126704 14308575.90082997 14526340.088004688 1.0 1.3703836384554786 1.3912396957748152 23.315796923611448 -11.902833491466133 0.45146164614282414 2.4821779347599644e-11 1.391254416932128 0.9998276476101218 0.002359387581819633 5.570494337262946 0.22537844922916453 5.334877392338573 0.004690822683367931 1.2507384715178872e-12 11.902833491466133 1.3912544169073062 TGISDVFAK(ub)NDLAVVDVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGISDVFAKNDLAVVDVR 18 1 P19338 P19338 NCL Nucleolin 1 93886700.0 30990000.0 38454700.0 24442000.0 True False 25769558.089778557 38247536.89843965 29552709.19296074 1.0 1.4842139226908382 1.1468069840391544 24.619164461511847 -10.06819605724557 8.489879461674203 0.9999999961274653 1.3155104533649964 0.5382964044622036 0.13774580589519542 1.006706007472321e-08 1.1704493623703492e-09 0.1333718050478968 0.044457267686834286 8.54680789974876e-11 10.06819605724557 0.31551045723753113 TGISDVFAK(ub)NDLAVVDVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGISDVFAKNDLAVVDVR 18 1 P19338 P19338 NCL Nucleolin 1 181409100.0 35720000.0 66582900.0 79106200.0 True False 46240244.146465495 62877503.08392694 64709683.29815598 1.0 1.3598004129208985 1.3994234782409176 25.462645679436918 -12.130865386420158 0.3466887199265249 4.0291450649575132e-22 1.4056070587533671 0.9996202389773612 0.003501509651074192 5.828411758595033 0.18342644188551632 4.205207690131483 0.011952041157499071 7.398345580664289e-13 12.130865386420158 1.4056070587533671 TGISHGHTVYVVHDGFEGLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGISHGHTVYVVHDGFEGLAK 21 0 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 0 31286300.0 11749000.0 9440300.0 10097000.0 False True 15403052.777477851 8031844.038001184 9052259.297263114 1.0 0.5214449469228103 0.5876925456296048 23.876712975550927 -10.49556684833994 6.1757863486551665 1.0003415932767052 0.55456874627632 0.98368096549839 0.02704546891938498 0.0001272977027554131 1.0397530247568673e-05 0.026206123246512267 0.008728887559595683 3.1947225825104826e-11 10.49556684833994 -0.4457728470003852 TGISHGHTVYVVHDGFEGLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGISHGHTVYVVHDGFEGLAK 21 0 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 0 19910900.0 4028000.0 1778900.0 14104000.0 False True 3900133.3448157245 2489224.046840952 10409739.289069563 1.0 0.6382407540372351 2.6690726620685346 21.895092019610775 -6.860862567740189 1.1814534031159918 0.8032770681366912 2.7690092357077902 0.9546758833575723 0.18830380555429785 0.14591056123459611 0.3865290055330595 0.1242726628403755 0.29036046755847117 1.377645355068564e-07 6.860862567740189 1.965732167571099 up TGISHGHTVYVVHDGFEGLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGISHGHTVYVVHDGFEGLAK 21 0 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 0 46715600.0 8181900.0 29417000.0 9116700.0 False True 12412540.47701261 24167306.513929937 7314780.249008446 1.0 1.9470072672622138 0.5893056512125817 23.56529508656862 -6.719168914695064 1.762420570584894 1.5766598385795467 0.5915355004756531 0.5085535075150637 0.3985448959150192 0.3569279465712106 2.166264691333261 0.17959045844067884 0.45126096653047415 1.909110583801023e-07 6.719168914695064 -0.9851243381038937 TGISHGHTVYVVHDGFEGLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGISHGHTVYVVHDGFEGLAK 21 0 P17858;P17858-2 P17858 PFKL ATP-dependent 6-phosphofructokinase, liver type 0 11279100.0 4028000.0 3549500.0 3701600.0 False True 3349460.47065595 3530378.138979416 4475587.445735352 1.0 1.054013973267771 1.3362114540372123 21.67549729504505 -6.93883020319266 0.6703579645883755 0.9967593035142235 1.4097618960680702 0.9980066358339926 0.006581826235129847 0.08830434433829218 0.05707044251963476 0.006351499205006937 0.02441600854465119 1.1512504071772523e-07 6.93883020319266 0.41300259255384675 TGIVDISILTTGMSATSR ddPTM_RPMI8226_Bortezomib_2h_R1 2 TGIVDISILTTGMSATSR 18 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 34309400.0 13809700.0 10476600.0 10023100.0 False True 13371318.632547587 14659961.014747243 7397749.423445346 1.0 1.0963736201052698 0.5532550398909969 23.672638410183627 -6.8610571180477935 1.1804859204682117 1.052435838409028 0.526431410838913 0.9549068359990847 0.050243897108441356 0.14571045008206973 0.38525858341803765 0.0331836659682616 0.07754966312484494 1.3770283513645043e-07 6.8610571180477935 -0.526004427570115 TGIVDISILTTGMSATSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGIVDISILTTGMSATSR 18 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 41080300.0 14130300.0 16491000.0 10459000.0 False True 21436698.163303338 13548052.205228891 8391774.06565745 1.0 0.632002750704457 0.39146765988537385 24.353579372699986 -8.39567819580358 0.16428981985003432 1.3729636173006527 6.0789078805335945e-09 0.9998752285032166 0.0027952292102900065 0.114882993108739 0.03819633224403541 0.1452583291144598 0.13464666529024977 4.0208864075455145e-09 8.39567819580358 -1.372963611221745 down TGIVDISILTTGMSATSR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TGIVDISILTTGMSATSR 18 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 11881310.0 2774760.0 2712700.0 6393850.0 False True 3800663.7570695053 2592843.944300699 4883754.315474224 1.0 0.6822081904714209 1.2849740539110026 21.857819965619598 -6.7634456889938495 1.5993306508423468 0.8161997316791011 1.287571755329663 0.704916751503383 0.13373951924883223 0.2771776783225424 1.3980271459492015 0.06595261176118969 0.15797077224142314 1.72406768205973e-07 6.7634456889938495 0.47137202365056197 TGIVDISILTTGMSATSR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TGIVDISILTTGMSATSR 18 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 29381300.0 13809700.0 6260500.0 9311100.0 False True 11483377.423440278 6226773.44388805 11258007.960337812 1.0 0.5422423398866729 0.9803742875643507 23.453043685617903 -10.696458117051176 9.840481439196461 1.000245945583049 0.7613083137255119 0.28353115510189353 0.17886661863701464 0.0009660965839001783 2.9800288310153633e-05 0.17335992974250886 0.05772895293113257 2.011601185761372e-11 10.696458117051176 -0.23893763185753714 TGIVDISILTTGMSATSR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TGIVDISILTTGMSATSR 18 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 79092300.0 30920300.0 36635000.0 11537000.0 False True 40026937.880234 34596230.045246854 9437384.379616605 1.0 0.8643236749401976 0.23577582696569327 25.254467915860616 -6.941520747571584 0.6452623195555497 1.006911769239821 0.05841525483799989 0.9983563613288249 0.013497162601840001 0.08707970394709917 0.051501658523322544 0.01329509949133131 0.05374578143112599 1.1441402194445323e-07 6.941520747571584 -0.9484965144018211 down TGK(ub)CSACNVWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGKCSACNVWR 11 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 7909200.0 2928400.0 3830400.0 1150400.0 True False 3839160.7586659393 3258919.250782257 1031367.6434160124 1.0 0.8488624091674376 0.26864403661346026 21.87235954130229 -6.9458192346817516 0.6030003434974875 1.00649461879642 0.08115685868158962 0.9988309969406001 0.01077821726401321 0.08520926878776822 0.04325418293521933 0.011029666646415604 0.04880831152365175 1.1328717975436287e-07 6.9458192346817516 -0.9253377601148305 down TGK(ub)CSACNVWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGKCSACNVWR 11 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 6494000.0 2928400.0 2178900.0 1386700.0 True False 4011108.6170343836 2082628.9933412473 1059190.0199829699 1.0 0.5192153073334227 0.26406415809454764 21.935569602825183 -9.267277322517918 0.1954720260764422 1.457786304383005 2.1026131769038896e-19 0.9995619947404802 0.00638562389382841 0.6950888627852131 0.07127181864870587 0.33808992875689203 0.14472981445015762 5.404091297951948e-10 9.267277322517918 -1.457786304383005 TGK(ub)CSACNVWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGKCSACNVWR 11 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 5550570.0 4558600.0 991970.0 0.0 True False 3790677.880221508 986626.0607193715 0.0 1.0 0.26027694567962556 0.0 21.854024435394408 -8.9961429363027 0.4738767398818756 1.1116830078467779 3.77540297322284e-21 0.9961675217507551 0.026223823402188134 0.5066535077438309 0.19865228569895735 0.17257177681932104 0.0553465374131134 1.00892077239534e-09 8.9961429363027 -1.1116830078467779 TGK(ub)CSAFPDVPDKENFEIPIYSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGKCSAFPDVPDKENFEIPIYSK 23 2 E9PPJ1;Q8NG31-3;Q8NG31-4;Q8NG31-2;Q8NG31 E9PPJ1 CASC5 Protein CASC5 1 33104600.0 9926800.0 9861800.0 13316000.0 True False 15059681.346289838 8101884.739404923 10684086.763389865 1.0 0.537985137474435 0.7094497232520819 23.84418790799355 -10.205208711429481 4.979135490575521 1.0000415087778909 0.623717430362795 0.8652514047486648 0.07000012402042737 3.225839534734261e-05 5.149178527093618e-06 0.0677847901982425 0.022592442880067412 6.234351556137072e-11 10.205208711429481 -0.37632407841509585 TGK(ub)CSAFPDVPDKENFEIPIYSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGKCSAFPDVPDKENFEIPIYSK 23 2 E9PPJ1;Q8NG31-3;Q8NG31-4;Q8NG31-2;Q8NG31 E9PPJ1 CASC5 Protein CASC5 1 13552200.0 1333200.0 4228200.0 7990800.0 True False 1826120.0683753048 4041384.1432123766 6103537.615691868 1.0 2.2130988061524275 3.342352850391799 20.800350195738737 -6.971986967882949 0.20525326230572394 0.3717614195806316 5.215048447488394 0.9999940136631915 0.0023401767892482737 0.07566306462780964 0.006670786908710935 0.03512609070421043 0.1183379685601305 1.0666281276559246e-07 6.971986967882949 4.843287027907762 TGK(ub)CSAFPDVPDKENFEIPIYSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGKCSAFPDVPDKENFEIPIYSK 23 2 E9PPJ1;Q8NG31-3;Q8NG31-4;Q8NG31-2;Q8NG31 E9PPJ1 CASC5 Protein CASC5 1 34034700.0 9926800.0 6387900.0 17720000.0 True False 12850438.286481906 6032407.7495846115 14495141.822554054 1.0 0.46943206255699765 1.1279881276736143 23.615314230086 -6.692324536381106 1.8586888193330058 0.6680869554157104 1.1257454746178535 0.3811343858190809 0.2242888334129532 0.41166437484882495 2.7592780933519494 0.09648236912503592 0.25046386299046075 2.030838853470328e-07 6.692324536381106 0.45765851920214307 TGK(ub)DNWLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGKDNWLER 9 1 J3KRA9;Q96Q15-2;Q96Q15;H3BQN7;Q96Q15-3;I3L144 J3KRA9 SMG1 Serine/threonine-protein kinase SMG1 1 1723590.0 322280.0 529900.0 871410.0 True False 441435.6252895234 506487.2658550303 665600.905252297 1.0 1.147363821220459 1.507809671717707 18.75184353893096 -6.955928215263098 0.4894559337925749 0.992072886220345 1.678371066369448 0.9995881143854136 0.004329102317453825 0.08118900209597561 0.02675948272769848 0.005183595152312562 0.029728522464355624 1.1068067134554376e-07 6.955928215263098 0.686298180149103 TGK(ub)GQPSNKEDVDDLVSQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGKGQPSNKEDVDDLVSQLR 20 2 P12270 P12270 TPR Nucleoprotein TPR 1 7305800.0 2164200.0 2855900.0 2285700.0 True False 2837287.1581426105 2429810.852211007 2049197.689982599 1.0 0.8563852429380634 0.7222383832745632 21.436080740614322 -6.971946881297795 0.20645526352314053 1.0734891520828993 0.5014043902124611 0.9999938473043144 0.00028126904200395083 0.07567588647378747 0.006720029427712465 0.004132490533095932 0.01401716253452985 1.0667265849341698e-07 6.971946881297795 -0.5720847618704382 TGK(ub)GQPSNKEDVDDLVSQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGKGQPSNKEDVDDLVSQLR 20 2 P12270 P12270 TPR Nucleoprotein TPR 1 9155700.0 3805400.0 2834000.0 2516300.0 True False 3684599.659970647 3965630.9791147597 1857205.5426181084 1.0 1.0762718734947587 0.5040454090018842 21.81307644510288 -6.873303893280311 1.1164138940929778 1.0441353588511813 0.4683512223902913 0.9678735240469846 0.04547119476133003 0.1337293115473663 0.30950887589324494 0.03154063122449591 0.07513611245712444 1.338739589777654e-07 6.873303893280311 -0.57578413646089 TGK(ub)PIAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGKPIAVK 8 1 O75534-2;O75534;O75534-3;O75534-4;E9PLD4 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 5114890.0 2184800.0 2285000.0 645090.0 True False 2864293.9576332965 1944086.906860241 578342.2749402258 1.0 0.6787316300686531 0.20191442760229028 21.449748130870884 -7.304519949392645 0.4362717008401233 1.0226839360877973 2.7529604761530452e-24 0.9992064081062615 0.009236441565540501 0.10169464950592903 0.037874320234495704 0.012597124128072993 0.05391040675545508 4.959981431116118e-08 7.304519949392645 -1.0226839360877973 down TGK(ub)PIAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGKPIAVK 8 1 O75534-2;O75534;O75534-3;O75534-4;E9PLD4 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 5070170.0 2218400.0 2241600.0 610170.0 True False 2147978.106290764 3136682.5697895726 450348.17229236977 1.0 1.4602954101828127 0.20966143508327162 21.034547857756106 -6.807031965237766 1.4267035761959361 1.2517364452120558 0.1891658284204914 0.8520597200674991 0.19864661236465167 0.21083627400523694 0.846320067866834 0.10949467484921781 0.2536726929099911 1.5594377198074046e-07 6.807031965237766 -1.0625706167915645 down TGK(ub)PIAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGKPIAVK 8 1 O75534-2;O75534;O75534-3;O75534-4;E9PLD4 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 4568050.0 2184800.0 1667700.0 715550.0 True False 2992579.601999974 1594015.4996535853 546551.8272148361 1.0 0.5326560064060742 0.18263568556357518 21.512958192393775 -8.061981664973066 0.3211782723837656 1.1125978436019917 3.171529517410304e-24 0.9988602198746908 0.01130412003786433 0.09393297834921364 0.06689898037589007 0.0612328431234058 0.08946901700266735 8.669984778923748e-09 8.061981664973066 -1.1125978436019917 down TGK(ub)PIAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGKPIAVK 8 1 O75534-2;O75534;O75534-3;O75534-4;E9PLD4 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 4575010.0 2218400.0 1785200.0 571410.0 True False 1844697.8917833054 1775582.7732655443 690889.18909867 1.0 0.9625330961640846 0.37452701180829884 20.814953133190382 -6.919883236136343 0.8255983595721308 1.0130288687890494 0.2799618786469443 0.9941482456935052 0.021910848714445753 0.098240694648278 0.10597283513047974 0.018866716867377856 0.0564513411964966 1.2025877173654087e-07 6.919883236136343 -0.7330669901421052 down TGK(ub)TVSPQSNSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGKTVSPQSNSSR 13 1 Q9H7N4;M0R3G4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 4258100.0 1207200.0 1975500.0 1075400.0 True False 1653534.4633533356 1888215.8778951007 821412.6685582218 1.0 1.1419271383469298 0.4967617468900001 20.65712168415517 -6.84903704266479 1.2397366076189904 1.0756795684223914 0.4714469716554098 0.9388906671425151 0.06842908371139678 0.15852035325371255 0.4693269502067431 0.043201840341235045 0.09991164474336105 1.4156730265511735e-07 6.84903704266479 -0.6042325967669817 down TGK(ub)TVSPQSNSSRPTCAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGKTVSPQSNSSRPTCAR 18 2 Q9H7N4;M0R3G4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 18927100.0 3361500.0 9001300.0 6564300.0 True False 4406959.052812306 7658341.126792583 5885089.205211864 1.0 1.7377835906837853 1.3354081884324038 22.07135206122451 -10.127139477216064 4.155920471616269 0.99987877605513 1.5365958894324303 0.703370864605774 0.1642690704386749 18529435.676907122 9030516.075580586 20135.02318507392 0.056233672565092804 7.46209068792584e-11 10.127139477216064 0.5367171133773003 TGK(ub)TVSPQSNSSRPTCAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGKTVSPQSNSSRPTCAR 18 2 Q9H7N4;M0R3G4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 31885300.0 7826400.0 9393900.0 14665000.0 True False 7577955.215954767 13144933.25854134 10823796.559430333 1.0 1.7346279944840206 1.4283268046559199 22.85337718318625 -10.116956839749106 4.560728042250314 0.9999579956564911 1.5814773993790252 0.8277391940121112 0.125046937378427 87189611.52134356 5.792570928996326 49993.98411791595 0.04280689267655116 7.639116974647857e-11 10.116956839749106 0.5815194037225341 TGK(ub)TVSPQSNSSRPTCAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGKTVSPQSNSSRPTCAR 18 2 Q9H7N4;M0R3G4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 15515300.0 3361500.0 6599500.0 5554300.0 True False 4604337.391121802 6307912.268371911 4242488.734399224 1.0 1.3699934936425346 0.9214113506494325 22.1345621227474 -6.687584636108095 1.8747229299705466 1.2324791341107253 0.9229927145820362 0.3592950435777854 0.1565577588075138 0.4218657729152716 2.8726669779653964 0.0668500312613516 0.17463166587253356 2.0531248707126117e-07 6.687584636108095 -0.30948641952868905 TGK(ub)TVSPQSNSSRPTCAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGKTVSPQSNSSRPTCAR 18 2 Q9H7N4;M0R3G4 Q9H7N4 SCAF1 Splicing factor, arginine/serine-rich 19 1 13624500.0 4919600.0 7051300.0 1653600.0 True False 6368519.179813878 6658888.956409147 1352661.7673688137 1.0 1.0455945516370033 0.2123981618295677 22.60252652260695 -6.893963613238188 0.9986725646356318 1.0406082987987926 0.1349224288482385 0.9833152840144592 0.04940455747509612 0.11598490330441732 0.20354867515583291 0.03748479628145732 0.09488412920567163 1.2765457579497256e-07 6.893963613238188 -0.9056858699505541 down TGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPR 39 2 P38606;P38606-2;C9JVW8;C9JA17 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 63782000.0 36217000.0 10339000.0 17226000.0 False True 54943836.817361034 8493924.671024304 13821273.54957598 1.0 0.1545928563245225 0.2515527555077618 25.711454323880922 -10.552802348022853 6.3507015278034125 1.0011518603637253 0.20307280778758116 0.9890197243582317 0.039583713085106005 0.0006463137191562874 4.5511531162404904e-05 0.03837122605453632 0.01277558846330569 2.8002554553258096e-11 10.552802348022853 -0.7980790525761441 TGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGKPLSVELGPGIMGAIFDGIQRPLSDISSQTQSIYIPR 39 2 P38606;P38606-2;C9JVW8;C9JA17 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 55590100.0 36217000.0 10353000.0 9020100.0 False True 46883620.44380017 9776846.448981592 7378534.35404174 1.0 0.20853437418940776 0.1573797903019554 25.48258064597337 -13.613391848630075 0.3928847386373645 9.998972359152125 0.15380154372515395 0.9998194039913332 0.005183580935654742 18.801888236004842 0.20523997713461303 142.1177307109633 0.013357512613723418 2.4356122594337046e-14 13.613391848630075 -9.845170815426972 TGKPMINLYTDKDTGKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGKPMINLYTDKDTGKPK 18 3 Q92804-2;Q92804;A0A075B7D9 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 0 12223100.0 3550700.0 3301500.0 5370900.0 False True 4655002.085027715 2808929.069146206 4815170.78931073 1.0 0.6034216564973852 1.0344078695041146 22.1503503833077 -6.66481260462384 1.9561321150394488 0.7457448978304976 1.0326199587502192 0.2562010509829473 0.16866175953134102 0.4730879289689831 3.4848976266088685 0.06954509521161699 0.18704791183877623 2.1636519247242672e-07 6.66481260462384 0.2868750609197216 TGKPMINLYTDKDTGKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGKPMINLYTDKDTGKPK 18 3 Q92804-2;Q92804;A0A075B7D9 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 0 13392600.0 3367700.0 2842700.0 7182200.0 False True 3260794.206885784 3977804.9344846667 5300966.358618515 1.0 1.2198883713927051 1.6256672522983884 21.636791962856456 -6.96158733391397 0.4124531994219108 0.9805379079785238 1.8801369240389074 0.9998246152274894 0.0034321031933397363 0.07913888647981629 0.019071584428751457 0.0052292332066285864 0.0338530918006674 1.0924779145974713e-07 6.96158733391397 0.8995990160603836 TGKPMINLYTDKDTGKPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGKPMINLYTDKDTGKPK 18 3 Q92804-2;Q92804;A0A075B7D9 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 0 32738400.0 6107900.0 21170000.0 5460500.0 False True 9266130.847302634 17392048.09803505 4381229.781577832 1.0 1.8769482521496947 0.47282192036530607 23.143535624177744 -6.73781855313527 1.694613605068198 1.5230853308027283 0.47237027061711245 0.5951690345195566 0.36847925939822795 0.3217625734401219 1.8134279361076817 0.17207598213709288 0.4232857055493517 1.8288641502205445e-07 6.73781855313527 -1.050715060185616 TGKPMINLYTDKDTGKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGKPMINLYTDKDTGKPK 18 3 Q92804-2;Q92804;A0A075B7D9 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 0 12173800.0 3550700.0 3713500.0 4909600.0 False True 4863489.744059553 3549425.291097672 3750053.5963859484 1.0 0.7298103785318087 0.771062301707617 22.21356044483059 -10.045442132873733 4.815144312458717 1.0000059033148496 0.7504363401165607 0.9799193685377421 0.01684102713102595 23318972.629331365 1.863887957645583 1634.47350197732 0.0057651315295599035 9.006537614497828e-11 10.045442132873733 -0.24956956319828894 TGKPMINLYTDKDTGKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGKPMINLYTDKDTGKPK 18 3 Q92804-2;Q92804;A0A075B7D9 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 0 7805200.0 3367700.0 3038700.0 1398800.0 False True 2800391.764406172 3022329.9199652756 1691282.6126795458 1.0 1.0792525382983926 0.6039450030443099 21.417197238290733 -6.864041709169073 1.1650497721651096 1.0435592591824234 0.5790758752824335 0.9583718811583568 0.042420832346269366 0.14270146829871144 0.3657750606200051 0.0283471431415706 0.0665061096687008 1.3675974767163683e-07 6.864041709169073 -0.4644833838999899 TGKPMINLYTDKDTGKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGKPMINLYTDKDTGKPK 18 3 Q92804-2;Q92804;A0A075B7D9 Q92804-2 TAF15 TATA-binding protein-associated factor 2N 0 17618500.0 6107900.0 5644400.0 5866200.0 False True 7906796.954708759 5330284.178173632 4798611.792294954 1.0 0.6741395041135174 0.6068970557587446 22.914661946270193 -13.999999999999995 0.22183334448907588 2.982335919218661 0.5715547387390528 0.9994997951480858 0.003839448767835098 13.050198611476127 0.14919331918596562 11.343661336115185 0.03676895944535762 1.0000000000000123e-14 13.999999999999995 -2.410781180479608 TGLAVTVGQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGLAVTVGQAK 11 0 A0A3B3IS06;E7ETY2;Q13428-2;Q13428-8;Q13428-6;Q13428-7;Q13428;Q13428-3;Q13428-4;H0Y8Y7;Q13428-5;A0A6I8PRA0 A0A3B3IS06 TCOF1 Treacle protein 0 7714800.0 3544700.0 1317000.0 2853100.0 False True 4647136.026923629 1120508.7336257917 2557888.5808677226 1.0 0.24111812676324013 0.5504225755494028 22.147910444105232 -10.495014129096978 6.202330463184372 1.0004457719951598 0.3957703511610929 0.8357498290175546 0.12627301244981845 0.0007789016210410744 6.341687003999689e-05 0.12234853025838119 0.040754439524465697 3.1987910402963155e-11 10.495014129096978 -0.604675420834067 TGLAVTVGQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGLAVTVGQAK 11 0 A0A3B3IS06;E7ETY2;Q13428-2;Q13428-8;Q13428-6;Q13428-7;Q13428;Q13428-3;Q13428-4;H0Y8Y7;Q13428-5;A0A6I8PRA0 A0A3B3IS06 TCOF1 Treacle protein 0 4566300.0 1301700.0 1077900.0 2186700.0 False True 1260378.2460145548 1508311.091174243 1613937.670406158 1.0 1.1967130470108298 1.2805185074477399 20.265425328254526 -13.999999999993367 0.11658359569459485 0.05954967871439362 1.4206485227596877 0.9997098551890051 0.0020026820693728226 11.978186666796137 0.10462609491687831 2.622553134777261 0.1243452090115042 1.0000000000152728e-14 13.999999999993367 1.361098844045294 TGLIDYNQLALTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGLIDYNQLALTAR 14 0 P34897;P34897-3;G3V2Y4;G3V5L0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 45907000.0 10353000.0 17137000.0 18417000.0 False True 13572883.258594632 14580226.399502806 16511385.508338584 1.0 1.074217328898803 1.2164980125267952 23.694223886149633 -6.9608646653434665 0.4230741715113333 0.9939152205971897 1.3021944379372346 0.9998009252411182 0.0012674201602432694 0.07939372725891615 0.020000910117842653 0.0018444146655371338 0.011833956844274844 1.0942973175973563e-07 6.9608646653434665 0.3082792173400448 TGLIDYNQLALTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGLIDYNQLALTAR 14 0 P34897;P34897-3;G3V2Y4;G3V5L0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 72878000.0 25590000.0 10693000.0 36595000.0 False True 24777659.457257804 14962770.66325835 27009671.67353244 1.0 0.6038815203296167 1.090081640686237 24.5625365785308 -6.690016470436304 1.8658986632299825 0.7516736546041434 1.0884242508070947 0.37074970583327194 0.16752796625066532 0.4166109424307694 2.8120914191262374 0.07181836909653384 0.1870477688009488 2.041660514081514e-07 6.690016470436304 0.33675059620295134 TGLIDYNQLALTAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGLIDYNQLALTAR 14 0 P34897;P34897-3;G3V2Y4;G3V5L0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 105289000.0 14498000.0 67879000.0 22912000.0 False True 21994525.945774093 55765462.10895227 18383433.157313652 1.0 2.5354245982131176 0.8358185669760135 24.390641170981233 -6.668757373382368 1.9418487258510533 1.9810965704632932 0.8427324052158134 0.2735555939694564 0.6524012582212407 0.46395645622099424 3.371647235521383 0.27059395044726514 0.7241140453496635 2.144088100925636e-07 6.668757373382368 -1.1383641652474799 TGLIDYNQLALTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGLIDYNQLALTAR 14 0 P34897;P34897-3;G3V2Y4;G3V5L0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 55188000.0 10353000.0 24172000.0 20663000.0 False True 14180783.87930509 23104001.113885254 15782824.967843171 1.0 1.629247107249295 1.1129726750067772 23.757433947672524 -10.240324776640017 4.379732657643438 0.9998252858402791 1.3711098911349517 0.40791329991098424 0.21076815439657653 0.00035973744472295025 6.239714126200473e-05 0.2041708132612702 0.0680251293208043 5.750097693423968e-11 10.240324776640017 0.37128460529467266 TGLIDYNQLALTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGLIDYNQLALTAR 14 0 P34897;P34897-3;G3V2Y4;G3V5L0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 52541000.0 25590000.0 12597000.0 14354000.0 False True 21279218.829216927 12529137.460691284 17355355.034602668 1.0 0.5887968708460505 0.8156011352622263 24.342941853965076 -10.109559078736416 5.219438952708401 1.0000067038473677 0.7021990030537988 0.6968533396291197 0.09259245321900389 7.223278116052639e-06 1.2322055424060153e-06 0.08965427533970538 0.029884085774970155 7.770356084833786e-11 10.109559078736416 -0.2978077007935689 TGLIDYNQLALTAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGLIDYNQLALTAR 14 0 P34897;P34897-3;G3V2Y4;G3V5L0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 57513000.0 14498000.0 23486000.0 19529000.0 False True 18767946.798305076 22178983.45414677 15974922.384461502 1.0 1.1817479926013932 0.8511811417700837 24.161767493073683 -6.75743658360916 1.622043593253876 1.1059070869087468 0.8501219395541252 0.6804076969936415 0.0764185677726987 0.2872652352604962 1.488993876093654 0.03718215089194137 0.08958489927215467 1.7480885025258353e-07 6.75743658360916 -0.25578514735462166 TGLIK(ub)GSGTAEVELKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGLIKGSGTAEVELKK 16 2 P14618;P14618-3;P14618-2;H3BTN5;H3BQ34;H3BUW1;H3BTJ2;H3BT25 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 32753600.0 2810900.0 4013700.0 25929000.0 True False 4264340.804316206 3297423.875818767 20804121.784915596 1.0 0.7732552408759727 4.8786254991295355 22.023891311607258 -6.893832500373042 0.9994146404385799 0.7992503547652476 5.259450581375917 0.9832407643467833 0.24391355583591814 0.11608942776918407 0.2041146821002303 0.1849554810863888 0.4679454120186509 1.2769312034157574e-07 6.893832500373042 4.46020022661067 up TGLIPSNYVAEQAESIDNPLHEAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGLIPSNYVAEQAESIDNPLHEAAK 25 0 Q92882 Q92882 OSTF1 Osteoclast-stimulating factor 1 0 11092800.0 3224800.0 2196300.0 5671700.0 False True 3122430.489166276 3073294.0435531973 4186111.622647185 1.0 0.9842633980857013 1.340658066583549 21.57423802456771 -6.896568240918919 0.9826869576281456 0.9837552193194411 1.3755690723647123 0.984780899628431 0.020284094458932138 0.11397639517229552 0.19199831649393587 0.015575339726582801 0.039870664583487696 1.2689127438570215e-07 6.896568240918919 0.39181385304527117 TGLLGIFWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGLLGIFWK 9 0 Q8TBQ9 Q8TBQ9 TMEM167A Protein kish-A 0 45936000.0 10355000.0 17429000.0 18152000.0 False True 13575505.27796264 14828661.137709904 16273805.166279076 1.0 1.092310071270904 1.1987623910173446 23.694502560100833 -6.96925838644626 0.275327430418882 0.9751887305325333 1.3191069979639245 0.9999759997848414 0.0003978199464643753 0.07654411110458782 0.009888516664571346 0.00202076316434117 0.00982996594332902 1.0733506251036213e-07 6.96925838644626 0.3439182674313912 TGLLGIFWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGLLGIFWK 9 0 Q8TBQ9 Q8TBQ9 TMEM167A Protein kish-A 0 27023000.0 12677000.0 6348600.0 7997400.0 False True 12274575.574038982 8883629.087511642 5902641.023142726 1.0 0.7237422617121465 0.48088351304194593 23.549169804611765 -6.972640242056042 0.18452754026077975 1.1768442988882644 0.021184163138841125 0.9999963236385041 0.0004065874169378902 0.07545491173270479 0.005849418335158337 0.008987904060446101 0.02688920677932891 1.0650248910750051e-07 6.972640242056042 -1.1556601357494232 down TGLLGIFWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGLLGIFWK 9 0 Q8TBQ9 Q8TBQ9 TMEM167A Protein kish-A 0 47499000.0 10355000.0 14141000.0 23003000.0 False True 14183523.333353039 13516203.861966394 17570165.1616559 1.0 0.9529510788185175 1.2387729585031286 23.757712621623725 -6.864637329648619 1.161995555358215 0.9740816791634609 1.2538972570758995 0.9590368299232512 0.025325746335729905 0.14210554444598186 0.3619918571290757 0.016963294525518684 0.03983024948008556 1.365723147714122e-07 6.864637329648619 0.2798155779124386 TGLLGIFWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGLLGIFWK 9 0 Q8TBQ9 Q8TBQ9 TMEM167A Protein kish-A 0 19695700.0 12677000.0 3593600.0 3425100.0 False True 10541487.18632213 3574240.563526251 4141272.5741269006 1.0 0.3390641662178299 0.3928546798880822 23.32957508004604 -10.460080327711086 9.431512445511496 1.0000051269364756 0.3659594255398698 0.9946309119764198 0.02195988524905364 2.3674220722212814e-06 1.3553492186981811e-07 0.021262739083725245 0.007087522487850934 3.466727234533647e-11 10.460080327711086 -0.6340457013966058 TGLPSTLLAHIWSLCDTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGLPSTLLAHIWSLCDTK 18 0 P42566;B1AUU8 P42566 EPS15 Epidermal growth factor receptor substrate 15 0 16811300.0 5931000.0 3107700.0 7772600.0 False True 8997760.614180313 2553106.654429078 6236342.203148405 1.0 0.2837491197982559 0.6930993688940822 23.10113455378625 -10.66914998214455 6.426012363415642 1.003827045708271 0.4884242443478832 0.6755796784017426 0.16711653939432758 0.009201752995869776 0.00047376137088501346 0.16249843023247754 0.05393663116250385 2.1421506887995725e-11 10.66914998214455 -0.5154028013603877 TGLVEFAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGLVEFAR 8 0 P31939-2;P31939;F8WEF0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 10978000.0 1991600.0 5588000.0 3398400.0 False True 2611006.886681837 4754292.181853394 3046766.1677546734 1.0 1.8208654316861348 1.1668931948420156 21.316174832171647 -10.5121219216825 5.544991124607262 0.999026488471301 1.4938793132640669 0.4319584014889878 0.2669830477024426 0.0032189574744376894 0.00028322099743223385 0.25897451475000827 0.08616840812260466 3.0752333677573974e-11 10.5121219216825 0.4948528247927658 TGLVEFAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGLVEFAR 8 0 P31939-2;P31939;F8WEF0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 8897400.0 3517900.0 2859400.0 2520100.0 False True 3406226.1901011053 4001173.331574011 1860010.2086205494 1.0 1.1746646018992786 0.5460618599040657 21.699742809537984 -6.832562988749399 1.3162832279132715 1.0931809299368878 0.5282281303077895 0.9109192616398667 0.07907317342276966 0.17767689856454136 0.6011281866251612 0.047151845982601796 0.10851701480050059 1.4704051368540557e-07 6.832562988749399 -0.5649527996290983 TGLVEFAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGLVEFAR 8 0 P31939-2;P31939;F8WEF0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 11379100.0 1991600.0 4660600.0 4726900.0 False True 2727948.3409662903 4454679.2814568 3610503.5735613327 1.0 1.63297787372281 1.3235234404337821 21.37938489369454 -10.103430488621173 4.75537189528852 0.9999747626701202 1.4782506570259781 0.7610291939262532 0.12633424338703206 3.4919241598288835e-05 6.583564868116105e-06 0.12232926284160986 0.040774201767250925 7.880785579524469e-11 10.103430488621173 0.47827589435585793 TGLVEFAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGLVEFAR 8 0 P31939-2;P31939;F8WEF0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 6881800.0 3517900.0 1752100.0 1611800.0 False True 2925289.7193943835 1742661.0895353777 1948819.927878819 1.0 0.5957225631299716 0.6661972367927642 21.48014808497226 -10.725237071906102 6.866266154523888 1.004791573588994 0.630959899961388 0.9733767376217756 0.028771165043833705 0.0021255698642126033 8.505747239461557e-05 0.02805823590514555 0.009285853588812756 1.882621127042471e-11 10.725237071906102 -0.37383167362760605 TGLYNYYDDEKEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGLYNYYDDEKEK 13 1 P50454;E9PPV6;E9PR70;E9PKH2 P50454 SERPINH1 Serpin H1 0 19335500.0 2331400.0 12288000.0 4716100.0 False True 3536904.248170626 10095110.39341779 3783960.767859943 1.0 2.8542221346928547 1.0698510624982571 21.75405573194252 -6.63716481580123 2.0542896318898958 2.2151187433774635 1.0771603527590252 0.14398273292600283 0.7939231413335874 0.5405475101251432 4.356079372438698 0.3150738267214394 0.8793700215957584 2.3058719386998517e-07 6.63716481580123 -1.1379583906184383 TGLYNYYDDEKEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGLYNYYDDEKEK 13 1 P50454;E9PPV6;E9PR70;E9PKH2 P50454 SERPINH1 Serpin H1 0 8957100.0 2331400.0 2367500.0 4258200.0 False True 3018043.2587645515 2235746.54380024 3483251.292821651 1.0 0.7407934055641906 1.1541422684072242 21.525182054034968 -6.737178788697018 1.6971151159668054 0.8452718000711801 1.1542347949685605 0.5921926651758618 0.10891692679878928 0.3229345109959486 1.8251822501583606 0.050795137245010454 0.12503048861337085 1.831560257400117e-07 6.737178788697018 0.30896299489738044 TGNAWHSK(ub)NFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGNAWHSKNFTK 12 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 16388400.0 4538500.0 3990200.0 7859700.0 True False 6885236.308794012 3278117.634425104 6306226.849971118 1.0 0.47610822452647017 0.9159056519115594 22.715074739396073 -10.106810693688637 7.497183600348544 1.0000000611588677 0.696006938219016 0.38913809704952496 0.17954654788036759 1.8351935867099284e-07 2.2113873323446745e-08 0.17384523371916769 0.05794839915080804 7.81968585639831e-11 10.106810693688637 -0.3039931229398517 TGNAWHSK(ub)NFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGNAWHSKNFTK 12 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 10902500.0 2663800.0 5747200.0 2491500.0 True False 2215067.7263488895 5716238.692870118 3012461.1306055826 1.0 2.580615763966834 1.3599860152226775 21.078919379605114 -6.580867378267432 2.263265245722238 2.0757725081490572 1.363025209387281 0.0 0.6865103726841023 0.6967129088237499 6.71371988157936 0.2545466275455279 0.7673160500377922 2.625020030782932e-07 6.580867378267432 -0.7127472987617762 TGNAWHSK(ub)NFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGNAWHSKNFTK 12 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 20543900.0 4538500.0 5920400.0 10085000.0 True False 5875177.717209786 5590924.535550136 8249633.480838453 1.0 0.9516179432620386 1.4041504577254444 22.486201061488522 -6.880453006180973 1.0773264128369042 0.9698346039540119 1.4364937512563576 0.974046560268936 0.03268505809839319 0.1272269541676808 0.26989878248133764 0.023362192396435853 0.056558630503995795 1.3168824012581362e-07 6.880453006180973 0.4666591473023457 TGNLAK(ub)FNQVLDQFGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGNLAKFNQVLDQFGEK 17 1 O43242;O43242-2 O43242 PSMD3 26S proteasome non-ATPase regulatory subunit 3 1 39252000.0 0.0 0.0 39252000.0 True False 0.0 0.0 31493824.995237272 0.0 TGNQHFGYLYGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGNQHFGYLYGR 12 0 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 0 13393000.0 3266000.0 4264800.0 5862200.0 False True 4281757.627988991 3628508.4640601915 5255635.7781931 1.0 0.8474343433970571 1.2274482198240422 22.029771702554655 -6.797776083709349 1.4653044091648177 0.9155835036126234 1.2323908593901531 0.8254810420723174 0.06522854306990115 0.2239534438858174 0.9495909827193519 0.0350263692950272 0.08155939257132709 1.5930298597423676e-07 6.797776083709349 0.3168073557775297 TGNQHFGYLYGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGNQHFGYLYGR 12 0 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 0 11437700.0 3900800.0 1964700.0 5572200.0 False True 3776971.2391899657 2749214.955775148 4112673.657583207 1.0 0.7278887716298212 1.0888813806443594 21.84879836733684 -6.705092038316005 1.8131435889614815 0.8318762632832755 1.087900970639323 0.441603453447173 0.11475834409371367 0.3850072242626539 2.4641800142699357 0.050432434094672 0.12886910776184302 1.972004772636985e-07 6.705092038316005 0.25602470735604754 TGNQHFGYLYGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGNQHFGYLYGR 12 0 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 0 17866200.0 4815200.0 7850000.0 5201000.0 False True 7305010.4382736515 6449106.167670064 4173020.0703207157 1.0 0.8828332583730217 0.5712544979342836 22.80045490384985 -6.954125082034118 0.5115592810752102 1.0056616136958472 0.43472037636860555 0.9994864931880747 0.004100071511529483 0.08187043366752088 0.02942560344761385 0.004709867642813382 0.0257180978437527 1.1114115812783209e-07 6.954125082034118 -0.5709412373272416 TGNQHFGYLYGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGNQHFGYLYGR 12 0 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 0 9956400.0 3266000.0 2798700.0 3891700.0 False True 4473528.460331342 2675044.179936734 2972560.6120773964 1.0 0.5979718702267071 0.6644778586827693 22.092981764077546 -10.667373032263079 6.670261692535669 1.0022287056314236 0.631224864454748 0.9761881543368749 0.027150956092796823 0.0009042538558824179 4.509250597184339e-05 0.026416700625624 0.008762933398417582 2.15093342145705e-11 10.667373032263079 -0.3710038411766756 TGNQHFGYLYGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGNQHFGYLYGR 12 0 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 0 9014900.0 3900800.0 3067400.0 2046700.0 False True 3243688.034740499 3050875.307368774 2474655.507128412 1.0 0.9405575612368806 0.7629141522317786 21.629203642771117 -6.951537589424879 0.5417072386226353 1.002586403540266 0.6926577956651212 0.999316444132366 0.0026333026308094872 0.08287427252861518 0.033453064790485244 0.0028895905402075745 0.014715437353707589 1.1180530497189982e-07 6.951537589424879 -0.30992860787514487 TGNQHFGYLYGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGNQHFGYLYGR 12 0 Q8TAT6;Q8TAT6-2 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 0 15555100.0 4815200.0 4860600.0 5879300.0 False True 6233371.321782217 4590103.337189207 4809327.726712299 1.0 0.7363757267514789 0.771545200573297 22.5715812259423 -10.401656598950815 8.848095149310844 1.0000012496993973 0.7539604637275494 0.9849068997990078 0.014357877564270831 3.53953669970269e-07 2.392773112587961e-08 0.013902025804512698 0.004633985057775509 3.965914992277386e-11 10.401656598950815 -0.24604078597184786 TGPAAAQVQVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGPAAAQVQVGK 12 0 A0A3B3IS06;E7ETY2;Q13428-2;Q13428-8;Q13428-6;Q13428-7;Q13428;Q13428-3;Q13428-4;H0Y8Y7;Q13428-5;A0A6I8PRA0 A0A3B3IS06 TCOF1 Treacle protein 0 2027270.0 501480.0 856290.0 669500.0 False True 657445.1363392287 728534.8697922768 600226.562297479 1.0 1.1081302903066381 0.9129682906160765 19.3265109812618 -6.756304796149072 1.626289029098131 1.0630960498886715 0.9123805984777255 0.6757243019212336 0.04545913295783986 0.2891772218086021 1.506477876759029 0.022063802698063635 0.05321997521120672 1.7526500268962697e-07 6.756304796149072 -0.150715451410946 TGPAAAQVQVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGPAAAQVQVGK 12 0 A0A3B3IS06;E7ETY2;Q13428-2;Q13428-8;Q13428-6;Q13428-7;Q13428;Q13428-3;Q13428-4;H0Y8Y7;Q13428-5;A0A6I8PRA0 A0A3B3IS06 TCOF1 Treacle protein 0 2065830.0 501480.0 795360.0 768990.0 False True 686890.7079874352 760218.3652962011 587370.399846184 1.0 1.1067530197396516 0.8551147846608056 19.389721042784693 -6.791470573618555 1.4907280679919408 1.0595504962056437 0.852339405807811 0.8059692673530072 0.04542469911437223 0.2331681083476605 1.0236525303448931 0.023984012778883332 0.05608619609553529 1.6163277395065644e-07 6.791470573618555 -0.2072110903978327 TGPAAAQVQVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGPAAAQVQVGK 12 0 A0A3B3IS06;E7ETY2;Q13428-2;Q13428-8;Q13428-6;Q13428-7;Q13428;Q13428-3;Q13428-4;H0Y8Y7;Q13428-5;A0A6I8PRA0 A0A3B3IS06 TCOF1 Treacle protein 0 1372510.0 500660.0 546210.0 325640.0 False True 416320.97299866105 543267.4583158044 393729.81841075694 1.0 1.3049245499278548 0.9457362082309104 18.667336713383364 -6.681810725726709 1.8957013864531311 1.1926208272560324 0.9470928306188433 0.33227660524235547 0.12918443755129913 0.43453906974543294 3.0208020327397773 0.054652894365792716 0.1437967754891913 2.080603258300413e-07 6.681810725726709 -0.24552799663718905 TGPFAEHSNQLWNISAVPSWSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGPFAEHSNQLWNISAVPSWSK 22 0 Q15257;Q15257-2;A6PVN5;F6WIT2;Q15257-3;A6PVN9;Q15257-4;B7ZBQ0;Q68CR8;H0Y6E5;B4DDQ6;B7ZBP7;B7ZBP9 Q15257 PPP2R4;DKFZp781M17165 Serine/threonine-protein phosphatase 2A activator 0 6315700.0 1481200.0 2935700.0 1898800.0 False True 1941867.5439612025 2497705.003268976 1702330.390575736 1.0 1.2862386062511373 0.8766459874514221 20.889013366277226 -6.718839837769663 1.7636500938420159 1.1743612531144434 0.8773327686361643 0.5069649913596068 0.1204677471112407 0.3575761443266585 2.1730571834253203 0.05425106250319743 0.13636840350012452 1.9105577178229668e-07 6.718839837769663 -0.2970284844782791 TGPFAEHSNQLWNISAVPSWSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGPFAEHSNQLWNISAVPSWSK 22 0 Q15257;Q15257-2;A6PVN5;F6WIT2;Q15257-3;A6PVN9;Q15257-4;B7ZBQ0;Q68CR8;H0Y6E5;B4DDQ6;B7ZBP7;B7ZBP9 Q15257 PPP2R4;DKFZp781M17165 Serine/threonine-protein phosphatase 2A activator 0 9060900.0 1481200.0 3036600.0 4543100.0 False True 2028839.6679249164 2902432.9713066374 3470113.348081508 1.0 1.4305876492819298 1.710393089677075 20.952223427800117 -8.672770511523856 0.09477996214239642 3.9955966276487286e-17 2.662541918658071 0.9999787802440235 0.0013459407611881894 0.24453292459181983 0.025832930743606774 0.377708781704856 0.31845363506613117 2.1243667164088314e-09 8.672770511523856 2.662541918658071 TGPFAEHSNQLWNISAVPSWSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGPFAEHSNQLWNISAVPSWSK 22 0 Q15257;Q15257-2;A6PVN5;F6WIT2;Q15257-3;A6PVN9;Q15257-4;B7ZBQ0;Q68CR8;H0Y6E5;B4DDQ6;B7ZBP7;B7ZBP9 Q15257 PPP2R4;DKFZp781M17165 Serine/threonine-protein phosphatase 2A activator 0 9407700.0 2580600.0 2697200.0 4129900.0 False True 2145883.2399639376 2682669.648247717 4993442.995499897 1.0 1.250147071512055 2.326987276150129 21.03314014881671 -6.943190772567412 0.6291778192885622 0.988253349103374 2.6468352326391313 0.9985526887567118 0.021902325438258083 0.08634063872263835 0.04820367407346528 0.02187620220632266 0.09145887388837885 1.1397490199514747e-07 6.943190772567412 1.6585818835357573 up TGPLNFVTCMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGPLNFVTCMR 11 0 A0A1W2PRB8;Q9H0W9;Q9H0W9-2;E9PQS1;A0A087WT99;E9PPB5;E9PJU8;Q9H0W9-4 A0A1W2PRB8 C11orf54 Ester hydrolase C11orf54 0 4565900.0 1703600.0 1425600.0 1436700.0 False True 2333466.9580589295 1362612.278171225 1097381.0497652935 1.0 0.5839432495348895 0.4702792323565355 21.154043608178824 -13.999999999999998 0.1820838166286224 3.172741607353648 0.3819061452184751 0.9994957726558319 0.0051130084898830174 12.232385486146297 0.13528761503909784 9.407645703723995 0.08338613827921768 1.0000000000000041e-14 13.999999999999998 -2.790835462135173 TGPNLHGLFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGPNLHGLFGR 11 0 C9JFR7;P99999;CON__P62894 C9JFR7 CYCS Cytochrome c 0 33609500.0 10204000.0 6407500.0 16998000.0 False True 13377542.815676553 5451525.976239378 15239210.016329445 1.0 0.40751325197411997 1.139163613699766 23.67330981059543 -6.69123235920501 1.8620875803949688 0.629001319528566 1.1366791576313606 0.3763940313631665 0.2505132436893822 0.41390339732164166 2.7834794826569986 0.10758929807214528 0.27973035928690165 2.03595249701997e-07 6.69123235920501 0.5076778381027947 TGPNLHGLFGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGPNLHGLFGR 11 0 C9JFR7;P99999;CON__P62894 C9JFR7 CYCS Cytochrome c 0 25204800.0 7029500.0 4701300.0 13474000.0 False True 6806352.370253756 6578553.606955621 9944755.188664464 1.0 0.966531447255993 1.4610990803424568 22.698450412025604 -6.890697985929377 1.0182155660889203 0.9738693045178431 1.5042274174067298 0.981342280015309 0.030824568067160326 0.11857983822882824 0.21854032552165112 0.023044623814555083 0.05759848798759466 1.2861807759741666e-07 6.890697985929377 0.5303581128888867 TGPNLHGLFGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGPNLHGLFGR 11 0 C9JFR7;P99999;CON__P62894 C9JFR7 CYCS Cytochrome c 0 14446900.0 2604000.0 9395900.0 2447000.0 False True 3950458.377900102 7719128.234498231 1963349.3774418007 1.0 1.953982929596488 0.49699280175315624 21.91358863050152 -6.730044435250547 1.7229955845736369 1.5740708320021075 0.4978407349535961 0.5595062943632463 0.4010302059566979 0.33615377097717736 1.9550735556391015 0.1844422985310334 0.4576706846321351 1.861896625203198e-07 6.730044435250547 -1.0762300970485115 TGPNLHGLFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGPNLHGLFGR 11 0 C9JFR7;P99999;CON__P62894 C9JFR7 CYCS Cytochrome c 0 29584500.0 10204000.0 6222500.0 13158000.0 False True 13976694.552731466 5947569.374944195 10050351.397516344 1.0 0.42553476091969555 0.7190792758329403 23.736519872118322 -10.529273522897098 6.4209900764169285 1.0004060711032599 0.5723070183763322 0.7389338705673107 0.1198390463883761 0.0006972694370729389 5.1117213771688995e-05 0.11613962311259836 0.03867788590729656 2.956150068012885e-11 10.529273522897098 -0.4280990527269276 TGPNLHGLFGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGPNLHGLFGR 11 0 C9JFR7;P99999;CON__P62894 C9JFR7 CYCS Cytochrome c 0 18639100.0 7029500.0 5757400.0 5852200.0 False True 5845340.709651438 5726383.743445578 7075867.96248445 1.0 0.979649267319962 1.2105142050661388 22.47885568745988 -6.885417301501147 1.0491552999965235 0.9861985437613718 1.2286725952167723 0.9777976102447474 0.01555091216988203 0.12293830350265297 0.24422158914417857 0.011356697039024538 0.027882366201159595 1.3019152031005846e-07 6.885417301501147 0.24247405145540046 TGPNLHGLFGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGPNLHGLFGR 11 0 C9JFR7;P99999;CON__P62894 C9JFR7 CYCS Cytochrome c 0 13264400.0 2604000.0 5440600.0 5219800.0 False True 3370929.3325138898 5137825.827328229 4269849.959670857 1.0 1.5241570856356892 1.2666684876738699 21.684714952593968 -10.005437723827594 4.284558515074784 0.9999789430803864 1.3954127864919956 0.7587047980009073 0.10511928034509 73060052.35717519 108615073.29311226 20964.89334131054 0.038469721627043686 9.875572375355921e-11 10.005437723827594 0.39543384341160925 TGPTQQQVEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGPTQQQVEGR 11 0 I3L172;Q9BUT9-2;Q9BUT9 I3L172 FAM195A Protein FAM195A 0 2117990.0 274120.0 990160.0 853710.0 False True 359373.9745818559 842431.9876134506 765376.2785645722 1.0 2.3441652629232532 2.129748765071578 18.455126408879533 -10.177163642394037 4.452848647603173 0.9997340005739368 2.2369570140275594 0.9779610943515041 0.08753516880609809 30698780.271011923 42.892586421523966 84403.95007748525 0.029965616564743544 6.650225281405316e-11 10.177163642394037 1.2372230134536226 TGPTQQQVEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGPTQQQVEGR 11 0 I3L172;Q9BUT9-2;Q9BUT9 I3L172 FAM195A Protein FAM195A 0 2497020.0 274120.0 1160000.0 1062900.0 False True 375469.57181446 1108747.3643929726 811864.9111126397 1.0 2.9529619644940635 2.16226552577695 18.518336470402424 -10.500340253652977 6.0146621260372255 0.9984612250810596 2.5576137451355025 0.8380342909153498 0.3228004693821267 0.006664271871630012 0.0005536254689142179 0.3127159964957381 0.1041834035054094 3.1598011029322656e-11 10.500340253652977 1.559152520054443 TGQAFTLLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGQAFTLLLK 10 0 Q8N8A6 Q8N8A6 DDX51 ATP-dependent RNA helicase DDX51 0 3359500.0 1381600.0 0.0 1977900.0 False True 1811290.9794334308 0.0 1773245.8813565138 1.0 0.0 0.9789955901570175 20.78858689963452 -11.943748031274993 13.944861140464072 0.863429620975771 0.5405480155706746 0.0 0.4814992415342125 0.0 0.0 0.0 0.13742158938869586 1.1382875052781431e-12 11.943748031274993 -0.3228816054050965 TGQAFTLLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGQAFTLLLK 10 0 Q8N8A6 Q8N8A6 DDX51 ATP-dependent RNA helicase DDX51 0 4209790.0 1381600.0 991690.0 1836500.0 False True 1892414.8563361224 947873.8567197112 1402756.5239047555 1.0 0.5008805831057976 0.7412521198552692 20.85179696115741 -10.100540549273347 5.0694854803952 1.0000104415846298 0.6210663514795348 0.7681746298328804 0.09813126895761747 1.158114206990377e-05 2.0548208762166563e-06 0.09501780978508015 0.031671730867423 7.933401806121596e-11 10.100540549273347 -0.378944090105095 TGQAPGYSYTAANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGQAPGYSYTAANK 14 0 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 0 4717040.0 706240.0 1583700.0 2427100.0 False True 925887.4792378894 1347418.1332142493 2175966.974387175 1.0 1.4552720102914962 2.3501419159250787 19.82047735149785 -6.960382997339311 0.4300015669137723 0.9644549926497166 2.8752758492114716 0.999784142382758 0.008240020077516955 0.079564587557924 0.020627846055576448 0.011668900082648355 0.07430187525606678 1.0955116558557941e-07 6.960382997339311 1.910820856561755 TGQAPGYSYTAANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGQAPGYSYTAANK 14 0 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 0 5158100.0 1243100.0 1275100.0 2639900.0 False True 1203638.470938539 1784254.079558656 1948430.994697586 1.0 1.4823837245476055 1.6187842460521338 20.198970693558426 -11.705033312985396 0.21805215686091642 1.2385070624947728e-17 1.702958355478225 0.9993546628422485 0.006743458351435661 4.492409748309949 0.12934559318394134 2.1542296590066194 0.07597111057790701 1.9722714452913823e-12 11.705033312985396 1.702958355478225 TGQAPGYSYTAANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGQAPGYSYTAANK 14 0 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 0 4055140.0 706240.0 1237200.0 2111700.0 False True 967356.0134183738 1182536.4131267099 1612959.9518266672 1.0 1.2224417863987291 1.6673902156527711 19.88368741302074 -6.960042444257287 0.434841910298812 0.9832073058218367 1.9238246628189948 0.9997717526457089 0.00419186051382439 0.07968605804318352 0.021075931984881065 0.0058310218968132465 0.03690482918234994 1.0963710409051931e-07 6.960042444257287 0.9406173569971581 TGQAPGYSYTAANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGQAPGYSYTAANK 14 0 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 0 3567200.0 1243100.0 1196300.0 1127800.0 False True 1033692.7286674323 1189855.2944530428 1363617.765641972 1.0 1.1510725203484065 1.31917128545526 19.979375968992702 -6.969745942461561 0.2641832270466218 0.9551524717283154 1.5201060156524997 0.9999803311072353 0.0005781258256125472 0.07638523643024206 0.009324687171033345 0.003416547220218404 0.01576296077997883 1.0721463157317097e-07 6.969745942461561 0.5649535439241843 TGQAPGYSYTAANKNK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGQAPGYSYTAANKNK 16 1 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 1 5825200.0 2147100.0 1481200.0 2196900.0 True False 2814868.8925459795 1260210.7336723777 1969585.862152849 1.0 0.4476978437644206 0.6997078504680931 21.42463629714349 -10.390003873629611 5.986242413703251 1.0000950884456357 0.5737028471162609 0.792328367297544 0.10288265441656183 0.00013059367365148402 1.3307348850480949e-05 0.0996377488255219 0.03320523393074626 4.0737664424822975e-11 10.390003873629611 -0.4263922413293748 TGQAPGYSYTAANKNK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGQAPGYSYTAANKNK 16 1 C9JFR7;P99999 C9JFR7 CYCS Cytochrome c 1 6465300.0 2147100.0 1260800.0 3057400.0 True False 2940940.8931957837 1205093.6870919466 2335305.0891295387 1.0 0.4097646742510446 0.7940673321699679 21.48784635866638 -9.934748158430892 5.506578154330784 1.0000005421034865 0.6019160032095183 0.588591874698549 0.15689090311972545 1.044233685538248e-06 2.0183867649664326e-07 0.15190917198274465 0.050636321245655126 1.1621223176948892e-10 9.934748158430892 -0.3980845388939682 TGQATVASGIPAGWMGLDCGPESSK ddPTM_RPMI8226_Bortezomib_1h_R1 2 TGQATVASGIPAGWMGLDCGPESSK 25 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 56916400.0 9635100.0 26477300.0 20804000.0 False True 12631709.406441128 22526990.047707062 18651401.646059375 1.0 1.783368293464712 1.4765540471148506 23.59054655158086 -10.499720016682474 5.0603628842170325 0.9981476821075559 1.6299611702897978 0.8489659060876953 0.12525639156234725 0.002624036740442245 0.0002594184236224238 0.12157845377683602 0.04042632654390889 3.1643169917414754e-11 10.499720016682474 0.6318134881822419 TGQATVASGIPAGWMGLDCGPESSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGQATVASGIPAGWMGLDCGPESSK 25 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 21246000.0 9904200.0 3917300.0 7424500.0 False True 9589796.592284992 5481498.318449636 5479800.719774321 1.0 0.5715969328128931 0.5714199114695331 23.193068784107318 TGQATVASGIPAGWMGLDCGPESSK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TGQATVASGIPAGWMGLDCGPESSK 25 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 52801400.0 9635100.0 20850500.0 22315800.0 False True 13197456.84878705 19929255.96661692 17045267.648327637 1.0 1.5100830557705953 1.2915569903829032 23.653756613103752 -10.127003062532298 4.535971399124182 0.9999577028070813 1.4008200230396484 0.8177081449533496 0.08921289265828956 62265911.44334999 2.5262774218784956 28588.799141399482 0.030539946074453917 7.464434946651508e-11 10.127003062532298 0.40086232023256707 TGQATVASGIPAGWMGLDCGPESSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGQATVASGIPAGWMGLDCGPESSK 25 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 17958800.0 9904200.0 2186900.0 5867700.0 False True 8235781.130454494 2175118.735634337 7094608.940820548 1.0 0.26410594225132145 0.8614372854793229 22.973474059541594 -10.366221591453112 8.125103752311105 1.000003098796273 0.5627716138659792 0.41669625283340606 0.24385949971331458 1.368860877969469e-05 1.0678634816401271e-06 0.23611761575077223 0.07870531510034495 4.3030699756326404e-11 10.366221591453112 -0.43723148493029373 TGQATVASGIPAGWMGLDCGPESSKK ddPTM_RPMI8226_Bortezomib_1h_R1 2 TGQATVASGIPAGWMGLDCGPESSKK 26 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 97278900.0 24563100.0 39859900.0 32855900.0 False True 32202461.969398763 33912958.29267331 29456286.64404745 1.0 1.0531169425772475 0.9147215722834814 24.94066765488881 -6.8026786061127265 1.445045973355364 1.0292085350205473 0.9126846514478815 0.839841570010721 0.022813663303996243 0.21696484643706312 0.8941603105920289 0.012418582508384181 0.028833992347186685 1.5751481007729596e-07 6.8026786061127265 -0.11652388357266585 TGQATVASGIPAGWMGLDCGPESSKK ddPTM_RPMI8226_Bortezomib_8h_R1 2 TGQATVASGIPAGWMGLDCGPESSKK 26 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 306023000.0 35375000.0 230592000.0 40056000.0 False True 53666461.258915655 189441055.97648057 32138914.042831555 1.0 3.5299710756503173 0.5988640444872316 25.677517424829855 -6.678340008756203 1.9075428599716817 2.6031053210768613 0.6100984858050433 0.31662482224975086 1.07265090574478 0.44223637328196785 3.109656958369714 0.45142541224830607 1.1932480807845778 2.0972972685760966e-07 6.678340008756203 -1.993006835271818 TGQATVASGIPAGWMGLDCGPESSKK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TGQATVASGIPAGWMGLDCGPESSKK 26 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 112694000.0 24563100.0 49819000.0 38311900.0 False True 33644741.86281835 47617831.850597814 29263418.278348293 1.0 1.4153127417280462 0.8697768702659606 25.0038777164117 -6.703137509042824 1.8192425579756617 1.2570818580444032 0.8712742990473313 0.4327478690256502 0.17520824280177275 0.38899581771021813 2.5049764981728484 0.0767630960735708 0.1966855132991924 1.980899721605473e-07 6.703137509042824 -0.38580755899707186 TGQATVASGIPAGWMGLDCGPESSKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGQATVASGIPAGWMGLDCGPESSKK 26 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 29638100.0 17821000.0 3394800.0 8422300.0 False True 14818951.104160793 3376511.5385849583 10183363.989684673 1.0 0.2278509129864743 0.6871852075161674 23.82094000049372 -9.942968621175702 6.068664992751005 1.0000002087449469 0.4575180602615632 0.6503175098725731 0.1875224404935299 5.295245522039626e-07 9.228614759206142e-08 0.18156789261102466 0.060522607422581864 1.1403321763361751e-10 9.942968621175702 -0.5424821484833837 TGQATVASGIPAGWMGLDCGPESSKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGQATVASGIPAGWMGLDCGPESSKK 26 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 95246000.0 22023000.0 33334000.0 39889000.0 False True 28509207.638230976 31478933.59705901 32629611.29570304 1.0 1.1041672569968455 1.1445288732594092 24.764924606950036 -13.999999953269803 0.13120462227713794 0.5048662174289923 1.2001972358016626 0.9996401886900701 0.0011549917739795597 11.935366698412013 0.1127626793016421 1.5223940103291953 0.049532080076013486 1.0000001076002599e-14 13.999999953269803 0.6953310183726703 TGQEIPVNVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGQEIPVNVR 10 0 Q96KP4;J3QKT2;J3QRH4 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 33880300.0 4876300.0 12926000.0 16078000.0 False True 6392876.522156376 10997491.185153367 14414402.79106628 1.0 1.720272735917604 2.254760081961378 22.60803379790816 -7.157850069319141 0.11997411087299516 3.668944157230345e-14 3.89085768866448 0.9999990990066913 0.00048797383073243244 0.08579923453260334 0.004759639539906277 0.052801208834720274 0.09771174200157104 6.952643009707947e-08 7.157850069319141 3.8908576886644433 TGQEIPVNVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGQEIPVNVR 10 0 Q96KP4;J3QKT2;J3QRH4 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 26989800.0 7052100.0 5323700.0 14614000.0 False True 6828234.945624383 7449481.1727287425 10786154.989397537 1.0 1.0909819641608058 1.579640284098519 22.703081268734895 -6.938222464356766 0.6759004338093292 0.9943097708886214 1.704798322064733 0.9979216598595845 0.0116034994090249 0.08858701208177694 0.05837372064964612 0.011148443380668335 0.042397787127430156 1.1528625606384047e-07 6.938222464356766 0.7104885511761115 TGQEIPVNVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGQEIPVNVR 10 0 Q96KP4;J3QKT2;J3QRH4 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 115583200.0 20358000.0 85270000.0 9955200.0 False True 30884574.36915909 70052902.28244913 7987550.3564808285 1.0 2.2682165357086155 0.2586258842685262 24.880383112768016 -6.736170495016186 1.7008807940663526 1.757939195751796 0.2584578693305005 0.5874968448138012 0.5329228296824828 0.32482269127389063 1.8436119061650331 0.24803087603628898 0.6111843074561345 1.8358174979466085e-07 6.736170495016186 -1.4994813264212956 TGQEIPVNVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGQEIPVNVR 10 0 Q96KP4;J3QKT2;J3QRH4 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 31748300.0 4876300.0 13760000.0 13112000.0 False True 6679199.887052582 13152037.701764893 10015215.650116619 1.0 1.9691037735312733 1.4994633817638545 22.67124385943105 -10.201117788123682 4.858734567945323 0.9999035488974082 1.7342835776493193 0.7652242481704907 0.1917298870778838 0.0002003451793031561 3.294042901667433e-05 0.18566582544737664 0.06188055496771024 6.29335473117678e-11 10.201117788123682 0.7343800287519111 TGQEIPVNVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGQEIPVNVR 10 0 Q96KP4;J3QKT2;J3QRH4 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 15848700.0 7052100.0 5993100.0 2803500.0 False True 5864133.611001207 5960813.980762795 3389698.8880805694 1.0 1.0164867269702407 0.5780391636577723 22.48348654416917 -6.898163193417874 0.9728210694214917 1.0191590976934835 0.5336978100032554 0.9856296859323503 0.024324311750355383 0.11276948117917719 0.18514939389531448 0.01881621231293225 0.04851990061537535 1.2642611909075474e-07 6.898163193417874 -0.485461287690228 TGQEIPVNVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGQEIPVNVR 10 0 Q96KP4;J3QKT2;J3QRH4 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 42171000.0 20358000.0 11546000.0 10267000.0 False True 26353832.316174254 10903454.950250292 8398511.348316165 1.0 0.4137331838283902 0.3186827345471766 24.651509434860465 -13.999999999999998 0.2560431954377125 5.204674625479056 0.28260288040479226 0.9995543694945407 0.006360045098773879 14.245824964825811 0.1601172102074454 30.91900875628461 0.04243935919666725 1.0000000000000041e-14 13.999999999999998 -4.9220717450742635 TGQEIYK(ub)QTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGQEIYKQTK 10 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 2020030.0 572510.0 669910.0 777610.0 True False 750566.154194726 569962.0392887276 697150.376561826 1.0 0.7593761537252282 0.9288326853877268 19.51761970967056 -9.949127488121402 5.367484743441779 1.0000003566905622 0.8441044197246617 0.5301787802941456 0.06918033936134761 2.9530410134505963e-07 5.7833570079333584e-08 0.06698372926837269 0.022327858518972118 1.1242748920993561e-10 9.949127488121402 -0.15589593696590054 TGQEIYK(ub)QTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGQEIYKQTK 10 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 2163370.0 520750.0 829770.0 812850.0 True False 504219.0762941383 1161101.4881933865 599940.2000227035 1.0 2.302771836256455 1.1898403456530984 18.943691175644638 -6.607782978475024 2.161452360754603 1.8716900525060989 1.1937172153794444 0.04354007890796219 0.5619880236801907 0.6189524949867077 5.4761103334426835 0.2149273208057899 0.6243059254364715 2.467271951003669e-07 6.607782978475024 -0.6779728371266545 TGQEIYK(ub)QTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGQEIYKQTK 10 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 4545480.0 578700.0 554180.0 3412600.0 True False 877930.2086370165 455282.24917189684 2738098.1142042857 1.0 0.5185859248182392 3.1188106836592095 19.74374673121878 -6.858886254838653 1.191302659577728 0.7395244573513311 3.242100377209227 0.9522737715417962 0.24675814819896452 0.14795829343766737 0.399634596986757 0.16162078422027337 0.3768226716352468 1.3839287934120128e-07 6.858886254838653 2.502575919857896 up TGQEIYK(ub)QTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGQEIYKQTK 10 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 1759990.0 572510.0 430690.0 756790.0 True False 784182.4185010087 411660.6916986287 578051.7885792973 1.0 0.5249552680427751 0.7371394396781592 19.58082977119345 -10.306580124896389 5.741384929747653 1.000038528332086 0.631047353860465 0.8012474776661854 0.08662382533364504 4.272485406858972e-05 5.160186158444498e-06 0.08388189417492925 0.027957719408497696 4.936508340371897e-11 10.306580124896389 -0.3689911744716211 TGQEIYK(ub)QTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGQEIYKQTK 10 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 1763120.0 520750.0 860470.0 381900.0 True False 433026.6981365656 855834.4773200784 461753.5242939085 1.0 1.9764011803497852 1.0663396189679815 18.724096451078914 -6.6294972141782385 2.081881048830859 1.6434854056445745 1.0699623735250445 0.11583621066969918 0.4188730909715407 0.5603013047507833 4.6270484639516125 0.164580624749011 0.4641410717693773 2.3469443173276243e-07 6.6294972141782385 -0.5735230321195299 TGQEYKPGNPPAEIGQNISSNSSASILESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGQEYKPGNPPAEIGQNISSNSSASILESK 30 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 12686300.0 2242200.0 5572400.0 4871700.0 False True 2939545.9134956887 4741019.64104508 4367623.2166462 1.0 1.6128408198282198 1.4858156141035577 21.4871618812075 -10.161635986915526 4.511992167157881 0.9999093975516224 1.5493282169775306 0.9614432070500546 0.05185782312249993 4.7271086325589345e-05 8.78335660903339e-06 0.0502193570976263 0.016737040438105574 6.892297467656955e-11 10.161635986915526 0.5494188194259082 TGQEYKPGNPPAEIGQNISSNSSASILESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGQEYKPGNPPAEIGQNISSNSSASILESK 30 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 11496300.0 2802800.0 2054200.0 6639300.0 False True 2713826.6481751525 2874452.7725114846 4900268.155269406 1.0 1.0591880562615674 1.8056673437724822 21.371897137610226 -6.9226882948170765 0.8045336953487954 0.9850704412354976 1.9338174284954777 0.9948957782085317 0.026194280376240758 0.09661561790455839 0.09760509517982785 0.022896540540037424 0.0704528155617417 1.1948453704143646e-07 6.9226882948170765 0.9487469872599801 TGQEYKPGNPPAEIGQNISSNSSASILESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGQEYKPGNPPAEIGQNISSNSSASILESK 30 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 13099500.0 2242200.0 3541600.0 7315700.0 False True 3071201.9331766497 3385120.401494958 5587882.33157094 1.0 1.102213555197138 1.8194447819297903 21.55037194273039 -6.932619198017304 0.7249694989888895 0.9900827917458829 1.9770168142929085 0.9970284852898996 0.019874593158382584 0.09130029523876484 0.0711832744687785 0.01839754867005075 0.06398795772754226 1.1678331582038898e-07 6.932619198017304 0.9869340225470257 TGQIK(ub)EVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGQIKEVER 9 1 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 1 4111300.0 1005700.0 1478200.0 1627400.0 True False 1318482.4392126552 1257658.3219784698 1459012.2591231058 1.0 0.953868086957224 1.1065845215157886 20.330446925487184 -6.825683728590918 1.3470224539329008 0.9752671657448495 1.1103450716328676 0.8969745557736009 0.02052759882455144 0.1861988122632069 0.6622375111545767 0.011970032469402045 0.027557415952163853 1.4938819208520055e-07 6.825683728590918 0.13507790588801805 TGQIK(ub)EVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGQIKEVER 9 1 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 1 3733120.0 844810.0 975110.0 1913200.0 True False 817991.968975614 1364476.5081314747 1412075.525230284 1.0 1.6680805678816542 1.7262706466405182 19.64172715333008 -11.330103346318461 0.4161023000663967 2.0372927686886512e-17 1.729157540452532 0.9996644335208597 0.006036102754873108 3.5403782692107337 0.20649113057490226 3.2546587662219277 0.014240447212932173 4.676238505480596e-12 11.330103346318461 1.729157540452532 TGQIK(ub)EVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGQIKEVER 9 1 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 1 5445530.0 804130.0 1774800.0 2866600.0 True False 1219923.9997775776 1458073.073424307 2300015.2535245884 1.0 1.19521631977906 1.8853758545154766 20.218359841244038 -6.947713345843722 0.5834067334174395 0.9918512050816394 2.1230777960544054 0.9990094125464536 0.011954075091564839 0.0844171272345894 0.03986393012197683 0.012479061065478499 0.05770748859571439 1.1279417034737915e-07 6.947713345843722 1.1312265909727661 TGQLFHIDFGHILGNFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGQLFHIDFGHILGNFK 17 0 Q68DL0;H0Y871;P42338 Q68DL0 DKFZp779K1237;PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 0 24042600.0 4594900.0 7851900.0 11595800.0 False True 4449037.414621098 10987204.617117567 8558512.113456676 1.0 2.4695689411398876 1.9236772622613607 22.085061800375826 -10.587762215466372 7.052905120266437 0.998519258049252 2.1966231017004736 0.8649887641689699 0.2228593446806068 0.005192414609418845 0.0003034929208712443 0.21592437992304536 0.07192754420789074 2.5836744145901812e-11 10.587762215466372 1.1981038436512215 TGQLFHIDFGHILGNFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGQLFHIDFGHILGNFK 17 0 Q68DL0;H0Y871;P42338 Q68DL0 DKFZp779K1237;PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 0 52763500.0 16305700.0 23314800.0 13143000.0 False True 24736939.00634632 19154091.780636165 10545280.289218465 1.0 0.7743113153863596 0.42629689495992407 24.560163653871818 -6.964794412466412 0.3615688544304494 1.0294560473800536 0.1591970924840093 0.9999088372545322 0.0022531230352053552 0.0780308554358866 0.015106743004755176 0.004654596552359775 0.029697142555229393 1.0844401478365208e-07 6.964794412466412 -0.8702589548960443 down TGQLFHIDFGHILGNFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGQLFHIDFGHILGNFK 17 0 Q68DL0;H0Y871;P42338 Q68DL0 DKFZp779K1237;PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 0 28694300.0 4594900.0 5974300.0 18125100.0 False True 3820862.938584169 5942115.2600942915 21914974.60900629 1.0 1.555176240447965 5.735608673031057 21.865467075810102 -6.931241000268331 0.7365343928491866 0.9392646976431527 6.621596464035048 0.996776560840379 0.12000704384322972 0.09199862072985332 0.0745608607497697 0.11015037161394518 0.3757092324541407 1.1715450670960345e-07 6.931241000268331 5.682331766391895 up TGQLFHIDFGHILGNFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGQLFHIDFGHILGNFK 17 0 Q68DL0;H0Y871;P42338 Q68DL0 DKFZp779K1237;PIK3CB Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 0 30447700.0 16305700.0 7196900.0 6945100.0 False True 21108050.08339932 6796386.188416455 5681163.0627438 1.0 0.3219807685486569 0.26914674924008347 24.331289975964268 -13.999999999999998 0.3618622025018642 9.97496475512132 0.26295367053849095 0.9997766440827626 0.004973339199438787 21.898952517099115 0.19455929022308027 151.91156268166918 0.015153689253522753 1.0000000000000041e-14 13.999999999999998 -9.71201108458283 TGQPMIHIYLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGQPMIHIYLDK 12 0 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2;H7BY36 B0QYK0 EWSR1 RNA-binding protein EWS 0 141108000.0 41257000.0 41650000.0 58201000.0 False True 54088326.533356324 35435982.35042841 52178918.82341396 1.0 0.6551502814304119 0.9646983400611437 25.68881392610716 -10.30722324059208 7.9099056824364595 1.0000006296914479 0.8099243116126003 0.3345449300632982 0.1263724657524039 1.4033204603122423e-06 1.228618324145313e-07 0.12236001857717237 0.040786537939852326 4.929203627417202e-11 10.30722324059208 -0.19007631807884762 TGQPMIHIYLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGQPMIHIYLDK 12 0 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2;H7BY36 B0QYK0 EWSR1 RNA-binding protein EWS 0 126428100.0 47730000.0 27945100.0 50753000.0 False True 46214837.27608111 39103724.16177132 37459266.74263672 1.0 0.8461292188084755 0.8105463299342631 25.461852767543558 -13.999999999963283 0.2057190530124067 1.8746051698670305 0.7886971351892621 0.9994880549330075 0.001860224153849344 12.64980240744632 0.1437875397781876 4.462837995581832 0.021727841682243097 1.0000000000845447e-14 13.999999999963283 -1.0859080346777685 TGQPMIHIYLDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGQPMIHIYLDK 12 0 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2;H7BY36 B0QYK0 EWSR1 RNA-binding protein EWS 0 180326000.0 44975000.0 86720000.0 48631000.0 False True 68230363.11292516 71244138.45354736 39019061.53427552 1.0 1.044170589208711 0.5718724004106022 26.02391055836209 -6.88400016618044 1.057191652956303 1.0291455222403545 0.5357170294498707 0.976773277892832 0.03246142907189374 0.12414776049282535 0.2513499048444022 0.023560507426982832 0.057603215260265274 1.3061703883326937e-07 6.88400016618044 -0.49342849279048384 TGQPMIHIYLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGQPMIHIYLDK 12 0 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2;H7BY36 B0QYK0 EWSR1 RNA-binding protein EWS 0 163168000.0 41257000.0 48231000.0 73680000.0 False True 56510827.82850279 46099994.94141156 56278301.48723238 1.0 0.815772776879403 0.9958852780926148 25.75202398763005 -10.731409980481216 8.381848289291144 1.000528002841606 0.9058290274892776 0.2671252264096229 0.0735306207114642 0.0007295080213720661 2.3376537298326048e-05 0.07158758311386265 0.023731905787649592 1.856051487466197e-11 10.731409980481216 -0.0946989753523283 TGQPMIHIYLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGQPMIHIYLDK 12 0 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2;H7BY36 B0QYK0 EWSR1 RNA-binding protein EWS 0 99594600.0 47730000.0 23530200.0 28334400.0 False True 39689609.79751951 23403438.14222099 34258992.036536574 1.0 0.5896615830091542 0.8631728104990759 25.242258042977834 -9.900120676556217 5.297697071627764 1.000000407625481 0.7264171967513757 0.5715567249120656 0.11166049105502177 5.376580174511202e-07 1.1160548061426471e-07 0.10811496666822362 0.036038268522403154 1.25857564525494e-10 9.900120676556217 -0.2735832108741052 TGQPMIHIYLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGQPMIHIYLDK 12 0 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2;H7BY36 B0QYK0 EWSR1 RNA-binding protein EWS 0 139883000.0 44975000.0 59437000.0 35471000.0 False True 58221024.08978962 56129278.70067791 29015641.96319496 1.0 0.9640723360364499 0.49837051849940767 25.79503688045454 -6.922313453316663 0.8074023107246541 1.0094445561706835 0.41912999534866235 0.9947992625531471 0.016476623040150542 0.09683013876376914 0.09870702458709854 0.014372924532138997 0.044052507418317816 1.1958770919496062e-07 6.922313453316663 -0.5903145608220212 down TGQPMIHIYLDKETGKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGQPMIHIYLDKETGKPK 18 2 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2;H7BY36 B0QYK0 EWSR1 RNA-binding protein EWS 0 27386400.0 10944000.0 7020800.0 9421600.0 False True 14347689.98184677 5973324.006864059 8446743.210368836 1.0 0.4163265316174053 0.5887179902169596 23.77431514187886 -10.89767454432881 11.33085748671148 1.0344618427512307 0.5025222609171824 0.9173783371222852 0.07037851826383985 0.036234223999095615 0.00032721940546587844 0.04029964325809574 0.02271456909721719 1.2656844826713936e-11 10.89767454432881 -0.5319395818340482 TGQPMIHIYLDKETGKPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGQPMIHIYLDKETGKPK 18 2 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2;H7BY36 B0QYK0 EWSR1 RNA-binding protein EWS 0 105433000.0 16885000.0 48216000.0 40332000.0 False True 25615779.45884917 39611478.086672574 32360362.521856423 1.0 1.5463702031908493 1.263297982942201 24.610529456230722 -10.119163807981124 4.65461205497384 0.9999678394271763 1.4048340930731333 0.731693675700388 0.11556375001693331 3.857161021397388e-05 7.299074894718033e-06 0.11190299542994185 0.03729803993354224 7.600395497722474e-11 10.119163807981124 0.4048662536459571 TGQPMIHIYLDKETGKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGQPMIHIYLDKETGKPK 18 2 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2;H7BY36 B0QYK0 EWSR1 RNA-binding protein EWS 0 27450700.0 10944000.0 6600900.0 9905800.0 False True 14990292.55047956 6309250.411742735 7566254.056354869 1.0 0.42088907808146103 0.5047435886174759 23.83752520340175 -10.7142118685028 6.858912714082879 1.0058874459929559 0.4628163333497923 0.9820525293274358 0.03423346057401207 0.0030890614985309827 0.0001287107550981179 0.03322217823172322 0.011048801890516413 1.931026045298381e-11 10.7142118685028 -0.5430711126431635 TGQPMIHIYLDKETGKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGQPMIHIYLDKETGKPK 18 2 B0QYK0;Q01844-6;Q01844-3;Q01844;Q01844-5;A0A0D9SFL3;C9JGE3;Q01844-2;H7BY36 B0QYK0 EWSR1 RNA-binding protein EWS 0 84984000.0 16885000.0 35208000.0 32891000.0 False True 21857965.35310946 33248643.84968065 26905175.49015944 1.0 1.5211225433180944 1.2309094216004866 24.38165577832317 -10.158998153456507 5.292890832295744 0.9999919900612786 1.3760159821881768 0.6911954871067543 0.1184790108513429 1.8595882555015737e-05 2.9550074212407062e-06 0.11472086416667598 0.03823893631918497 6.934287543469895e-11 10.158998153456507 0.3760239921268982 TGQPMINLYTDR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TGQPMINLYTDR 12 0 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 85074000.0 17402200.0 24026700.0 43645100.0 False True 22814452.723144546 20442010.01534307 39129123.72536175 1.0 0.8960114127394909 1.715102448443415 24.44344471080355 -6.875034319222689 1.1070735402903273 0.9389492962220503 1.7679050143295143 0.9694566070077673 0.06363190778800262 0.13212181965871714 0.299614805783468 0.04445513409246689 0.10627560581005122 1.333416057555342e-07 6.875034319222689 0.828955718107464 TGQPMINLYTDR ddPTM_RPMI8226_Bortezomib_2h_R1 2 TGQPMINLYTDR 12 0 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 68962300.0 22288800.0 10640900.0 36032600.0 False True 21581254.24427231 14889866.861560436 26594581.105170757 1.0 0.6899444625889722 1.2323000695026327 24.36327537701751 -6.751662460483418 1.6438437664590622 0.8180489951416523 1.2335066138235433 0.6560469969159815 0.13029889331497688 0.2971470375820242 1.5803401494894322 0.06260465484667532 0.15171378864798762 1.7714852455892524e-07 6.751662460483418 0.415457618681891 TGQPMINLYTDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGQPMINLYTDR 12 0 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 116714000.0 16483000.0 83897000.0 16334000.0 False True 25005916.068712503 68924924.85974717 13105577.740553483 1.0 2.7563447253982547 0.52409908537409 24.575766122029684 -6.696902431603165 1.841497411906166 2.0939499153801555 0.5310443389798872 0.40288391082249164 0.7418123345365948 0.4021090994392264 2.6487063518375837 0.3216044393599216 0.8303876808310998 2.0095442251731583e-07 6.696902431603165 -1.5629055764002682 TGQPMINLYTDR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TGQPMINLYTDR 12 0 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 81302700.0 17402200.0 27146500.0 36754000.0 False True 23836263.616772242 25947077.868529107 28073462.172390606 1.0 1.0885547452274191 1.1777626990430197 24.506654772326442 -6.9710340319492055 0.23216584718016486 0.9646883376386318 1.3041847015743013 0.9999893560427046 0.0002366946225105785 0.07596861473567104 0.007819277130805867 0.002256020198996111 0.008823290037857383 1.0689711098048398e-07 6.9710340319492055 0.3394963639356695 TGQPMINLYTDR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TGQPMINLYTDR 12 0 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 41912900.0 22288800.0 12493700.0 7130400.0 False True 18534124.761260293 12426393.958294718 8621333.67275538 1.0 0.670460252014066 0.46516001072656754 24.143680652451785 -8.941085861204709 0.12450202498206561 1.55387860814954 1.3363667051620642e-15 0.9999248978147606 0.0019091655544649 0.4265929556072221 0.038821019560338545 0.2701811932342743 0.18616366503031676 1.1452864927952246e-09 8.941085861204709 -1.5538786081495386 TGQPMINLYTDR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TGQPMINLYTDR 12 0 H3BPE7;P35637-2;P35637 H3BPE7 FUS RNA-binding protein FUS 0 75905400.0 25414700.0 27131000.0 23359700.0 False True 32899830.14863321 25621135.999934275 19108474.29076274 1.0 0.7787619536084042 0.5808076881988579 24.971576800015303 -6.9724421936819025 0.19105496389408771 1.1323269933569844 0.22182892210827931 0.9999956924552851 0.00035531901930891194 0.07551794095845397 0.006102628220694312 0.00692614603734762 0.021516498039038736 1.065510677926735e-07 6.9724421936819025 -0.9104980712487051 TGQSVYMHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGQSVYMHLK 10 0 Q92995;Q92995-2;H7C502 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 0 3066090.0 1050200.0 1038300.0 977590.0 False True 1376822.370151266 883389.6872616998 876438.3645054422 1.0 0.6416148563628039 0.6365660404029835 20.392911012433835 TGSESSQTGTSTTSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGSESSQTGTSTTSSR 16 0 E7EX17;P23588-2;P23588 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 30916400.0 3797400.0 15874000.0 11245000.0 False True 4978428.174073906 13505661.076367378 10081475.2696567 1.0 2.712836382113662 2.025031780544282 22.247258885229368 -10.43399137206476 5.765054209141002 0.9992530146008887 2.368934081328973 0.8408074014874816 0.28079505276388306 0.002697121482408225 0.0002648015991745949 0.27199999781923395 0.09062621358766193 3.68136287169705e-11 10.43399137206476 1.3696810667280845 TGSESSQTGTSTTSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGSESSQTGTSTTSSR 16 0 E7EX17;P23588-2;P23588 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 11362600.0 4415300.0 3029900.0 3917400.0 False True 4275138.718313028 4239754.8707197625 2891315.420519082 1.0 0.9917233451532941 0.6763091471473928 22.027539802182453 -6.912529326419981 0.878319604385455 1.0090021085046617 0.633260403470696 0.9918418643130298 0.013609452307400797 0.1027695149190027 0.1298655480012103 0.0112834906847059 0.03172199692452005 1.2231245228483848e-07 6.912529326419981 -0.37574170503396565 TGSESSQTGTSTTSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGSESSQTGTSTTSSR 16 0 E7EX17;P23588-2;P23588 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 24083400.0 3797400.0 11903000.0 8383000.0 False True 5201401.400876367 11377086.102042696 6403108.0533044245 1.0 2.187311692599961 1.231035169142221 22.31046894675226 -10.084476588908386 4.143089246338592 0.9998927622442433 1.7091734288780558 0.42306300278294173 0.3903982566022435 273478210.35020286 557547373.827706 431689.0939868609 0.14287112673409916 8.232342130139626e-11 10.084476588908386 0.7092806666338125 TGSESSQTGTSTTSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGSESSQTGTSTTSSR 16 0 E7EX17;P23588-2;P23588 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 6295930.0 4415300.0 917430.0 963200.0 False True 3671517.5809551193 912487.622494403 1164600.666666383 1.0 0.24853145936918702 0.3171987171482971 21.80794507761673 -10.145567719559008 5.2457426725649485 1.0000236302866958 0.28286508834122026 0.9931705958734798 0.028033290600790295 7.747564493600054e-06 1.261955306274991e-06 0.027144008918127602 0.009047705636119991 7.152078629842954e-11 10.145567719559008 -0.7171585419454756 TGSMSK(ub)QELDDILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGSMSKQELDDILK 14 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y5M9 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 20482000.0 3662000.0 0.0 16820000.0 True False 5555521.728060752 0.0 13495519.627532097 1.0 0.0 2.4292083242815314 22.405490973133222 -6.7949138066248915 1.4765165241663596 0.44464477922383444 2.4587029650965446 0.8168840419830439 0.4265797142984117 0.2281060888697671 0.9822102040460016 0.22733967511586098 0.5304465610912492 1.603563614501414e-07 6.7949138066248915 2.01405818587271 TGSMSK(ub)QELDDILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGSMSKQELDDILK 14 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y5M9 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 6495800.0 0.0 3886600.0 2609200.0 True False 0.0 3865662.1143703028 3154771.656422273 0.0 TGSMSK(ub)QELDDILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGSMSKQELDDILK 14 1 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y5M9 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 1 26008500.0 3662000.0 3358500.0 18988000.0 True False 4740531.188811784 3171596.522641226 15532378.833332755 1.0 0.6690382145626571 3.276505989453463 22.17661729522567 -6.875048567491049 1.1070889901482135 0.8057044250650517 3.444577089952802 0.9694650406239613 0.20253812932512602 0.13210410372442705 0.29958758282917114 0.14150415818144887 0.3382690874529234 1.333372311758507e-07 6.875048567491049 2.6388726648877503 up TGSNIDCEK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGSNIDCEKLR 11 1 H0Y6Y2;P55211-4;P55211;Q5JRU8;Q5JRU2;F8VVS7 H0Y6Y2 CASP9 Caspase-9;Caspase-9 subunit p35;Caspase-9 subunit p10;Caspase 1 2730170.0 618450.0 469920.0 1641800.0 True False 810793.9390783191 399809.7677338131 1471922.2852576585 1.0 0.49310897438170564 1.8154085943598517 19.628975778714818 -6.802796697694877 1.44448945471642 0.721311147934453 1.8349433425641717 0.8402107417983614 0.21773740817821904 0.21678813600779478 0.8927180325392348 0.11856881475098116 0.275288363481077 1.5747198511598326e-07 6.802796697694877 1.1136321946297187 TGSSAQK(ub)SLSEYNNFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGSSAQKSLSEYNNFK 16 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 33263600.0 9320000.0 9733600.0 14210000.0 True False 12218610.255008392 8281384.821275634 12739685.511945019 1.0 0.6777681461671228 1.0426460330644427 23.542576866534603 -6.673578992415141 1.9247343081798698 0.7949584978977272 1.0411957744616505 0.29501610478199436 0.1367648593510137 0.4529264833399217 3.238192171909285 0.057136318162679785 0.15194237014332676 2.1204156824801568e-07 6.673578992415141 0.24623727656392325 TGSSAQK(ub)SLSEYNNFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGSSAQKSLSEYNNFK 16 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 47422600.0 8778000.0 9414600.0 29230000.0 True False 8499347.194834273 13173898.87649043 21573786.11879637 1.0 1.5499894961929845 2.53828742658124 23.018920606463634 -6.9620833403225335 0.4050042282210849 0.9485816255784328 3.1760754023344187 0.9998398325305253 0.00805466138749882 0.07896514297244119 0.018442047791733158 0.012714916494303476 0.0826539916590782 1.0912309111247207e-07 6.9620833403225335 2.2274937767559857 TGSSAQK(ub)SLSEYNNFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGSSAQKSLSEYNNFK 16 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 80120000.0 13221000.0 24330000.0 42569000.0 True False 20057223.584568854 19988121.408842348 34155218.49134446 1.0 0.9965547486951448 1.7028886549194169 24.257618579334476 -6.90580265121024 0.9238563589285843 0.9751224859268243 1.7864236708684667 0.9892384533831193 0.03445756373765244 0.10725948184352531 0.15431247258257724 0.027637947042256236 0.07424583397869405 1.2422166579885947e-07 6.90580265121024 0.8113011849416424 TGSSAQK(ub)SLSEYNNFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGSSAQKSLSEYNNFK 16 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 29869000.0 9320000.0 6878000.0 13671000.0 True False 12765855.863529736 6574107.217495565 10442191.36308298 1.0 0.5149758298835936 0.8179781657189833 23.605786928057494 -10.312546709128277 6.4440936789587395 1.0000123911719927 0.6664769978012898 0.6176592519240196 0.12370018561135533 2.2022299880288004e-05 2.3493340635546373e-06 0.11977663509161633 0.039924063232962104 4.86915153776369e-11 10.312546709128277 -0.3335353933707029 TGSSAQK(ub)SLSEYNNFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGSSAQKSLSEYNNFK 16 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 44025000.0 8778000.0 13330000.0 21917000.0 True False 7299295.93133514 13258188.64420217 26499743.367241606 1.0 1.8163654096124677 3.63045198009864 22.79932588189791 -6.9579337343762475 0.46363653432742546 0.9489997712747873 4.571394730431079 0.9996857239346921 0.019488650206330244 0.08044764260237654 0.023922215987167122 0.02479320399372205 0.14980604402971648 1.1017073976971898e-07 6.9579337343762475 3.6223949591562916 TGSSAQK(ub)SLSEYNNFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGSSAQKSLSEYNNFK 16 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 48787000.0 13221000.0 18064000.0 17502000.0 True False 17114845.1248718 17058722.520467818 14316815.585685164 1.0 0.9967208231220027 0.8365144692358064 24.028744901426926 -6.911322700722087 0.886661182692272 1.0047552362764998 0.8152125734810131 0.9914116036632193 0.0070716099809126545 0.10355032169303875 0.13406437289920736 0.005827749292801665 0.01623892409224688 1.2265275262655748e-07 6.911322700722087 -0.1895426627954867 TGSTSSK(ub)EDDYESDAATIVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGSTSSKEDDYESDAATIVQK 21 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 21226100.0 6270400.0 10068000.0 4887700.0 True False 8220555.122639988 8565893.644756626 4381967.69012904 1.0 1.0420091486480703 0.5330500951281005 22.97080438970781 -6.886880490880478 1.0407015653459941 1.0294270918502042 0.49186608636177814 0.9788237614070721 0.03356612580291066 0.12170896373670517 0.23694623999130657 0.02467119633088576 0.06085165958674511 1.2975362777864918e-07 6.886880490880478 -0.5375610054884261 TGSTSSK(ub)EDDYESDAATIVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGSTSSKEDDYESDAATIVQK 21 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 11554600.0 2405200.0 3476100.0 5673300.0 True False 2328848.242539916 4864124.857622024 4187292.5346482177 1.0 2.0886396841028394 1.7980100455499939 21.151185199912696 -10.068349457147939 4.41343121540981 0.9999298894973072 1.943324864901488 0.933541271366281 0.11864905339495108 13629039.86188059 6218383.2582295835 9127.66671040408 0.04061672777198859 8.543789560737053e-11 10.068349457147939 0.9433949754041808 TGSTSSK(ub)EDDYESDAATIVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGSTSSKEDDYESDAATIVQK 21 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 34436400.0 8859400.0 14235000.0 11342000.0 True False 13440357.508897146 11694653.03143736 9100248.728624796 1.0 0.870114728994063 0.6770838292508724 23.680068178031572 -6.965410775344892 0.3509311664188009 1.0184553897004753 0.5222202945260104 0.9999213623100469 0.0011764532007783207 0.07782184002811939 0.014370007034644493 0.002643441499688013 0.016581340800112043 1.0829021716681144e-07 6.965410775344892 -0.49623509517446496 TGSTSSK(ub)EDDYESDAATIVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGSTSSKEDDYESDAATIVQK 21 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 18107500.0 6270400.0 5876400.0 5960700.0 True False 8588736.331188511 5616761.217343844 4552905.424469956 1.0 0.653968290649178 0.530101897288064 23.0340144512307 -13.999999999999998 0.14304066457401515 2.657911602985035 0.3822843671961787 0.9995910940664434 0.004021100049246031 11.93831993882463 0.11870844539865492 5.515854731451126 0.13243532399713775 1.0000000000000041e-14 13.999999999999998 -2.2756272357888565 TGSTSSK(ub)EDDYESDAATIVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGSTSSKEDDYESDAATIVQK 21 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 11509300.0 2405200.0 4692500.0 4411600.0 True False 2000030.3684264377 4667220.5711116735 5334045.163066259 1.0 2.333574852057721 2.6669820855084923 20.931590475346972 -10.224261580476954 0.31500641001294366 1.429471496068201e-23 2.76316039708771 0.9989651734146391 0.023168455749068635 1.670991661840039 0.14616655055016686 1.5389543709736613 0.11203934851961342 5.966757937543036e-11 10.224261580476954 2.76316039708771 TGSTSSK(ub)EDDYESDAATIVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGSTSSKEDDYESDAATIVQK 21 1 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 1 33716400.0 8859400.0 13995000.0 10862000.0 True False 11468667.944882318 13216165.94740628 8885227.453531722 1.0 1.1523714882079006 0.7747392719218618 23.45119450012402 -6.797164323238292 1.4673372788308654 1.084373494860326 0.7698762040123658 0.8237923607549391 0.06511571346470679 0.2248211043377364 0.955896774293736 0.03491526598996626 0.08134882321829695 1.5952754314748962e-07 6.797164323238292 -0.3144972908479603 TGSVDIIVTDLPFGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGSVDIIVTDLPFGKR 16 1 Q9BV44;H7C3J3 Q9BV44 THUMPD3 THUMP domain-containing protein 3 1 5661300.0 1232500.0 2466400.0 1962400.0 True False 1193374.9621363922 3451246.3821060862 1448388.5692619209 1.0 2.8920050207251116 1.2136910989560235 20.186615982869267 -6.617304287218289 2.1263291334546923 2.257736187348631 1.2199531755038295 0.07389967149378474 0.814181018338628 0.592689800079616 5.088051732889476 0.3150126072731722 0.903210800086936 2.4137690412878977e-07 6.617304287218289 -1.0377830118448013 TGTAEMSSILEER ddPTM_RPMI8226_Bortezomib_1h_R1 2 TGTAEMSSILEER 13 0 P25705;P25705-3;K7ERX7;K7ESA0 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 105266300.0 24598100.0 37627600.0 43040600.0 False True 32248347.30833928 32013708.75123599 38587171.58658834 1.0 0.9927240129591816 1.1965627639035588 24.942721890137843 -6.898619979457742 0.9699296093382616 0.9912012478647481 1.2173709834480875 0.9858677618941687 0.011224832856957082 0.11242899645797717 0.18319481148302813 0.008701554989003964 0.02248772674077194 1.2629321542955057e-07 6.898619979457742 0.22616973558333942 TGTAEMSSILEER ddPTM_RPMI8226_Bortezomib_2h_R1 2 TGTAEMSSILEER 13 0 P25705;P25705-3;K7ERX7;K7ESA0 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 87201200.0 26068700.0 13303100.0 47829400.0 False True 25241163.387784936 18615097.204750042 35301445.28875672 1.0 0.7374896679191311 1.3985664902371457 24.58927507116859 -6.798944271227957 1.4601133961771848 0.8549688143141385 1.407468399871101 0.8291017676533953 0.11235427494858712 0.222258817048844 0.9355676271244867 0.06053755386576423 0.14088618463548433 1.5887506043765555e-07 6.798944271227957 0.5524995855569625 TGTAEMSSILEER ddPTM_RPMI8226_Bortezomib_8h_R1 2 TGTAEMSSILEER 13 0 P25705;P25705-3;K7ERX7;K7ESA0 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 193755700.0 24462700.0 152333000.0 16960000.0 False True 37111704.362925075 125147985.96683854 13607848.566167919 1.0 3.3721972115045866 0.36667269261182955 25.14537092284538 -6.696279318716087 1.8439907314687476 2.4783539947054196 0.3761639844516435 0.40002758112742454 1.0020282218959033 0.4033022370857693 2.6633787357783567 0.4339365494538697 1.1211855887166362 2.0124295292149523e-07 6.696279318716087 -2.1021900102537763 TGTAEMSSILEER ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TGTAEMSSILEER 13 0 P25705;P25705-3;K7ERX7;K7ESA0 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 96124300.0 24598100.0 39132400.0 32393800.0 False True 33692682.308657825 37403401.174458176 24743051.611252844 1.0 1.1101342668953023 0.7343746450514792 25.005931951660735 -6.828247204543733 1.3358174195825547 1.058922735066847 0.7246269979222567 0.9023055441307639 0.0492972825168793 0.18298445627954246 0.639215972744783 0.02898156673710456 0.06669799767601084 1.4850900742825099e-07 6.828247204543733 -0.3342957371445904 TGTAEMSSILEER ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TGTAEMSSILEER 13 0 P25705;P25705-3;K7ERX7;K7ESA0 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 56511300.0 26068700.0 19892500.0 10550100.0 False True 21677279.08922264 19785335.154147882 12756077.131849067 1.0 0.9127222596854704 0.5884537943782366 24.369680346602866 -6.946572150584467 0.5952883607831567 1.0036935892783074 0.48101681921298495 0.9989040892883595 0.005861337075659989 0.08489209161386219 0.04188899126870378 0.0060440278330335115 0.027209686266020192 1.1309094924975513e-07 6.946572150584467 -0.5226767700653225 TGTAEMSSILEER ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TGTAEMSSILEER 13 0 P25705;P25705-3;K7ERX7;K7ESA0 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 76120700.0 24462700.0 26931000.0 24727000.0 False True 31667447.38190767 25432266.175748367 20226939.720445465 1.0 0.8031043951549564 0.6387297175080039 24.91649724493783 -6.973203969622181 0.1645426482694099 1.1563574517599144 0.28109717919404864 0.9999978050104155 0.00021872949512284645 0.07527614410186752 0.005103006317428703 0.007287441956939335 0.019404542260685373 1.0636433529138998e-07 6.973203969622181 -0.8752602725658658 TGTAYTFFTPNNIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGTAYTFFTPNNIK 14 0 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 58190000.0 15192000.0 18737000.0 24261000.0 False True 19916859.119537253 15941512.636253964 21750704.447944958 1.0 0.80040294207917 1.0920750263583885 24.247486817142455 -6.722479302655638 1.7504053573036926 0.8788959011792453 1.0916867200904317 0.5243083623581017 0.0839657485281512 0.35046062431902025 2.099823180567669 0.03806931562560996 0.09529026876736706 1.8946138045665498e-07 6.722479302655638 0.21279081891118634 TGTAYTFFTPNNIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGTAYTFFTPNNIK 14 0 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 109411000.0 21160000.0 59029000.0 29222000.0 False True 32101267.003212824 48494813.754317954 23446258.891542405 1.0 1.510682234114448 0.7303842209466626 24.93612690433727 -6.73013335679244 1.722676261377699 1.3072874224703246 0.7308346136472342 0.5598489387252416 0.21467756542428398 0.3360212849057515 1.9536200367085672 0.09875099231176848 0.2450132245594199 1.861515441979881e-07 6.73013335679244 -0.5764528088230904 TGTAYTFFTPNNIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGTAYTFFTPNNIK 14 0 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 50315000.0 15192000.0 15874000.0 19249000.0 False True 20808892.948363032 15172634.19170176 14702782.645599024 1.0 0.7291418255335559 0.7065624626011469 24.310696878665347 -13.999999999999998 0.3519881630901727 4.372086394143741 0.7035245395900083 0.9997584773580205 0.0020719928055169114 20.859359988462604 0.19112714476444706 52.64255906697056 0.006691444675949622 1.0000000000000041e-14 13.999999999999998 -3.668561854553733 TGTAYTFFTPNNIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGTAYTFFTPNNIK 14 0 J3KTA4;P17844;P17844-2 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 66002000.0 21160000.0 23256000.0 21586000.0 False True 27392037.12595773 21961783.156333026 17657569.49106388 1.0 0.8017579362697785 0.6446241807379453 24.70725322642972 -6.973745349663739 0.14270906355455124 1.2024677366689926 0.23980671744914125 0.999998829128168 0.00015723192174971865 0.07510498662789392 0.004332362984871081 0.008635271959008822 0.020217626691239245 1.062318269254911e-07 6.973745349663739 -0.9626610192198514 TGTCGYCGLQFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGTCGYCGLQFR 12 0 O75380 O75380 NDUFS6 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial 0 6383900.0 1479400.0 1709700.0 3194800.0 False True 1939507.7265299803 1454619.4243584026 2864232.742685566 1.0 0.7499941374097524 1.476783362863954 20.887259092553272 -6.813830553904201 1.398169268207561 0.8643431252225013 1.4906652776921852 0.8696080008584994 0.10886632925783185 0.20164605448219106 0.7761279924148579 0.061207853237039776 0.14137037664750524 1.53521585200405e-07 6.813830553904201 0.6263221524696838 TGTGTLSVFGMQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGTGTLSVFGMQAR 14 0 P04818;P04818-2;P04818-3 P04818 TYMS Thymidylate synthase 0 29617100.0 5502600.0 15592000.0 8522500.0 False True 8347846.493945131 12809485.779147958 6838024.139455545 1.0 1.5344658994914375 0.819136305922169 22.992972640777804 -6.7066858532048785 1.8068253236779392 1.329680950090467 0.8209616567288041 0.4494296592746643 0.2253410904771083 0.38178057058033005 2.427413740941878 0.09932278013884971 0.25336409636236523 1.9647809867303094e-07 6.7066858532048785 -0.5087192933616629 TGTINCGTK(ub)SSFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGTINCGTKSSFR 13 1 E9PH99;Q9Y4E5-2;Q9Y4E5;D6RIA1;D6RAV4 E9PH99 ZNF451 Zinc finger protein 451 1 3516240.0 938430.0 665810.0 1912000.0 True False 780346.1244979298 662223.1493770626 2311790.3599108476 1.0 0.8486274597738703 2.962519178778827 19.573754651406407 -6.88969362733335 1.0241612737879013 0.885582330458431 3.143267537277318 0.9807025308386871 0.1337483122136932 0.11939353689382053 0.2232869501353549 0.09954207782131023 0.24789550244520042 1.2891586668547563e-07 6.88969362733335 2.257685206818887 up TGTITTFEHAHNMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TGTITTFEHAHNMR 14 0 P13639 P13639 EEF2 Elongation factor 2 0 58165900.0 12902300.0 28502900.0 16760700.0 False True 16915040.24605092 24250378.423433997 15026463.5439871 1.0 1.4336577430902433 0.8883492634606803 24.01180327395999 -6.694802955850736 1.849147531540551 1.270636421506325 0.8901054351028369 0.3931100007848435 0.18323093918893182 0.40641295902489155 2.69784122510562 0.07915887917758818 0.20491131554670505 2.0192823263182665e-07 6.694802955850736 -0.38053098640348815 TGTITTFEHAHNMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 TGTITTFEHAHNMR 14 0 P13639 P13639 EEF2 Elongation factor 2 0 61460000.0 16078500.0 13864800.0 31516700.0 False True 15568096.818425942 19401086.943976842 23261530.789266795 1.0 1.246208009254817 1.4941794787488172 23.892089251631575 -6.971036726840052 0.23209554584317177 0.9017579303174856 1.8457327321910981 0.9999893767196063 0.00065754061772797 0.07596774102381627 0.007816145195740453 0.006274285568203589 0.02452939255532249 1.0689644766293306e-07 6.971036726840052 0.9439748018736125 TGTITTFEHAHNMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 TGTITTFEHAHNMR 14 0 P13639 P13639 EEF2 Elongation factor 2 0 318574400.0 54678000.0 206890000.0 57006400.0 False True 82950523.49724346 169968863.06105217 45739060.0532073 1.0 2.049039064433396 0.5514017045923436 26.305747750208756 -6.7184159408686766 1.764806257627531 1.639316417083088 0.5539185491543357 0.5050137401384863 0.4415312517195983 0.3584622526552599 2.180990324437114 0.19870805944311248 0.49980273340228715 1.9124234446583026e-07 6.7184159408686766 -1.0853978679287524 TGTITTFEHAHNMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TGTITTFEHAHNMR 14 0 P13639 P13639 EEF2 Elongation factor 2 0 56392100.0 12902300.0 24039900.0 19449900.0 False True 17672628.981547154 22977737.728681568 14856234.203264406 1.0 1.30018786410747 0.8406352115905629 24.075013335482883 -6.73042591398837 1.7214937850406489 1.1805622629232813 0.8408773257147176 0.561340096957698 0.1261874907145876 0.33543041694687487 1.9476189496214462 0.058081502464872425 0.144065949818177 1.8602618770135804e-07 6.73042591398837 -0.33968493720856363 TGTITTFEHAHNMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TGTITTFEHAHNMR 14 0 P13639 P13639 EEF2 Elongation factor 2 0 31216210.0 16078500.0 14427620.0 710090.0 False True 13369985.148322182 14349895.547401661 858566.5359147971 1.0 1.0732918090939279 0.06421596781074508 23.67249452706585 -6.9103048276486785 1.05723593147109 1.053016479085371 4.550071312644462e-19 0.9804501925209057 0.06423126629634832 0.11260146232802098 0.23110180673253497 0.04744316874087479 0.10988734771846738 1.229405558472861e-07 6.9103048276486785 -1.053016479085371 down TGTITTFEHAHNMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TGTITTFEHAHNMR 14 0 P13639 P13639 EEF2 Elongation factor 2 0 131464900.0 54678000.0 43141700.0 33645200.0 False True 70781748.86451407 40740826.47039783 27522118.828904957 1.0 0.5755837786430134 0.3888307264290128 26.076874072301205 -13.999999999999984 0.11145070141197154 3.0428994433004855 0.05328464740043378 0.999735701122581 0.0041573028061065425 12.004285517238237 0.10153883705760094 5.503783277927819 0.29793568654096353 1.0000000000000368e-14 13.999999999999984 -2.9896147959000516 TGTIVVEGHELHDEDIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGTIVVEGHELHDEDIR 17 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 6533000.0 1874800.0 2388800.0 2269400.0 False True 2457880.955589025 2032400.351469468 2034584.2576219556 1.0 0.8268912889568358 0.8277798210671976 21.22898361158462 -10.018803353295507 4.779297604510762 1.0000035299790944 0.8273355550074124 0.9999801343353758 0.0003627417309144696 1.364384462547694e-08 2.8007386415512988e-09 0.0003512303414592691 0.00011707438798482604 9.576275828604282e-11 10.018803353295507 -0.17266797497168196 TGTIVVEGHELHDEDIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGTIVVEGHELHDEDIR 17 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 6885900.0 2973700.0 1352600.0 2559600.0 False True 2879301.521221087 1892700.2337158166 1889163.9736459497 1.0 0.6573470057811587 0.6561188398375074 21.457287445544996 TGTIVVEGHELHDEDIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGTIVVEGHELHDEDIR 17 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 6871100.0 2973700.0 1975100.0 1922300.0 False True 2472763.307246676 1964459.7442733468 2324244.042289029 1.0 0.7944390546868373 0.9399379372370995 21.237692720979272 -9.915929217540187 5.225427376374873 1.000000287410474 0.8671884960107794 0.5262775091888405 0.05939967007082667 1.9891577329910872e-07 4.116646396775531e-08 0.057513607503445564 0.019171161078783496 1.213586627896009e-10 9.915929217540187 -0.13281179139969468 TGTQPQGK(ub)MEVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGTQPQGKMEVLR 13 1 Q75MM6;E7ET89;Q86UW9-2;Q86UW9 Q75MM6 DTX2 Probable E3 ubiquitin-protein ligase DTX2 1 17331400.0 1731100.0 3658300.0 11942000.0 True False 2240943.0750824898 3454712.389095848 9768678.535267519 1.0 1.5416332648113693 4.359181919383619 21.095674570988514 -6.938925766832511 0.669481470776697 0.9677105213264438 5.095564091774298 0.9980198019753005 0.06552831764530773 0.08826011878448621 0.05686687735330068 0.06327927940255826 0.24367093504771611 1.1509971099781677e-07 6.938925766832511 4.127853570447854 up TGTSCALDCGAGIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGTSCALDCGAGIGR 15 0 Q9BV86;Q9BV86-2 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 0 8571200.0 1877200.0 3995500.0 2698500.0 False True 2461027.37883066 3399386.9743370176 2419285.105839801 1.0 1.3812877514398936 0.9830386799635311 21.23082927713386 -6.656060454970487 1.9869827476383193 1.2462242661533312 0.984711654953995 0.21894787755178102 0.1624982083322417 0.49385441914232747 3.7439278183792 0.06617100365228107 0.18005644995885478 2.2076973941595876e-07 6.656060454970487 -0.2615126111993361 TGTSCALDCGAGIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGTSCALDCGAGIGR 15 0 Q9BV86;Q9BV86-2 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 0 19312200.0 2440600.0 15034000.0 1837600.0 False True 3702568.631759985 12351065.238821879 1474397.5545513094 1.0 3.335809938234934 0.39820937872810397 21.820095047250746 -6.694873878138446 1.8491181101635985 2.4577016212638343 0.4077562633758143 0.39323212253312356 0.9869354483318569 0.40632699824862606 2.697292443055206 0.42639029094962594 1.103568513825145 2.0189525951447898e-07 6.694873878138446 -2.04994535788802 TGTSCALDCGAGIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGTSCALDCGAGIGR 15 0 Q9BV86;Q9BV86-2 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 0 5907300.0 1877200.0 1760700.0 2269400.0 False True 2571251.569422534 1682906.4521437096 1733414.4597601146 1.0 0.6545086728023528 0.6741520278972214 21.294039338656752 -10.109424145588536 5.111686725139515 1.0000094095163792 0.6643303503491418 0.9974381444063901 0.00801936613871483 8.599753596534325e-07 1.498071936142838e-07 0.007764935418812684 0.0025882392915407247 7.772770671124425e-11 10.109424145588536 -0.3356790591672374 TGTVSLEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGTVSLEVR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 63243240.0 27072240.0 13690000.0 22481000.0 False True 35491968.8079451 11647505.363202043 20154881.772979267 1.0 0.32817298545001183 0.5678716185636754 25.08098926990587 -10.214546308574883 5.4482800606290205 1.0000290101413811 0.44802230200690263 0.8760920786089558 0.09785655719537169 3.448450374079396e-05 4.9713660162122105e-06 0.09475417108106496 0.03158306802787763 6.101739906683598e-11 10.214546308574883 -0.5520067081344785 TGTVSLEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGTVSLEVR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 20412100.0 6965700.0 2562400.0 10884000.0 False True 6744577.666331404 3585579.682739469 8033153.886998954 1.0 0.5316240482541263 1.1910536559019935 22.68529667628341 -6.715956801485161 1.7741202930245727 0.7138230993838721 1.1897845974751473 0.49331247635219044 0.1971975063908799 0.3632034834278151 2.231932817504781 0.08833888448613197 0.22280369374644954 1.923283025004939e-07 6.715956801485161 0.4759614980912752 TGTVSLEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGTVSLEVR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 60140000.0 15065000.0 20399000.0 24676000.0 False True 22854706.39902653 16758639.07188552 19798777.784124997 1.0 0.7332686221950038 0.8662888701544773 24.44598794981771 -10.150922296904783 4.836218081327533 1.0000156741897588 0.7997787461738016 0.7512939660550313 0.05430528882977119 41603412535.14093 7303847303.23237 7485498.291430645 0.018591809515701267 7.06443938485041e-11 10.150922296904783 -0.20023692801595716 TGTVSLEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGTVSLEVR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 48806240.0 27072240.0 10689000.0 11045000.0 False True 37081578.72777728 10216724.636203863 8436398.47891535 1.0 0.2755202174968527 0.22750915059060756 25.144199331428762 -13.744173520636833 0.3878455742594322 9.999999999980515 0.2238080134081926 0.9998145695861175 0.004812117853374174 20.39318331877479 0.20350705864488963 152.509342756944 0.012719986831543888 1.8022974961711607e-14 13.744173520636833 -9.776191986572323 TGTVSLEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGTVSLEVR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 18676900.0 6965700.0 6566500.0 5144700.0 False True 5792288.182832212 6531124.961151801 6220432.98359483 1.0 1.1275552519139898 1.0739163500240887 22.465701951717687 -10.074048784478569 5.799657644785932 0.9999995704798897 1.1007358009690502 0.8246442545972986 0.021897989998949503 1.216234901652721e-07 1.9393730042937753e-08 0.02120272800497278 0.007067545881773392 8.43240030942987e-11 10.074048784478569 0.10073623048916047 TGTVSLEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGTVSLEVR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 55082000.0 15065000.0 22251000.0 17766000.0 False True 19501939.475546002 21012712.289799012 14532770.2945539 1.0 1.0774678239642477 0.7451961540941568 24.21711427191016 -6.845290949092007 1.257539217580367 1.0412294941145226 0.7330678787705558 0.9331765257833219 0.036692640541846115 0.16271431824587865 0.4975315980174312 0.022856490438006263 0.052758046984307555 1.4279370129583566e-07 6.845290949092007 -0.3081616153439668 TGVAPDVFAENMK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGVAPDVFAENMKLR 15 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 24230700.0 3677000.0 4574700.0 15979000.0 True False 3560275.6476880433 6401401.566745342 11793620.540275287 1.0 1.7980072893800392 3.3125582700131035 21.76355751280729 -6.961056433920169 0.4202802864764751 0.9332557817860128 4.2344687142866375 0.9998073951895654 0.013310392976598341 0.07932588511030075 0.01975275926014777 0.019595521224989015 0.12606504156544618 1.0938142225473529e-07 6.961056433920169 3.3012129325006248 TGVAPDVFAENMK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGVAPDVFAENMKLR 15 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 27723200.0 3677000.0 5818200.0 18228000.0 True False 3057588.4187194495 5786856.201777719 22039390.52325048 1.0 1.8926210494352003 7.208095892932774 21.543962788241565 -6.93599455685277 0.6958266397710164 0.9342408770807652 8.487024164197619 0.9975908158085514 0.1345116155299551 0.08964235010712812 0.06329216697124398 0.12725871759708315 0.4661329982711886 1.1587918795615828e-07 6.93599455685277 7.552783287116854 TGVAPDVFAENMK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGVAPDVFAENMKLR 15 1 Q01581 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 1 155088300.0 5144800.0 6233500.0 143710000.0 True False 6660045.019169529 5886600.245313118 117556254.58912195 1.0 0.8838679360829823 17.650969963530454 22.667100498679737 -6.905339742315853 0.92689268839287 0.4012895843778702 19.614960932979834 0.9890407542105784 0.8246000149019279 0.10758082661116243 0.15608255819561562 0.659925997001405 1.7679059196160334 1.2435414266256237e-07 6.905339742315853 19.213671348601963 up TGVAVNKPAEFTVDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGVAVNKPAEFTVDAK 16 1 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 13360600.0 2790800.0 4346200.0 6223600.0 False True 3658765.8261456406 3697763.9013549066 5579641.572986691 1.0 1.010658806018845 1.5250064743456442 21.802925650409843 -6.911378410358978 0.8862961719051788 0.9847598307053715 1.593474662232464 0.9914311221344904 0.022680768317251618 0.1035144402868324 0.1338765873697036 0.018696386896447533 0.052116903227007176 1.2263702020912133e-07 6.911378410358978 0.6087148315270925 TGVAVNKPAEFTVDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGVAVNKPAEFTVDAK 16 1 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 12482600.0 2790800.0 3961800.0 5730000.0 False True 3822634.1785341986 3786754.576079372 4376692.013054315 1.0 0.9906139063328877 1.1449413699148612 21.866135711932735 -6.8924326292528155 1.0078613178449447 0.9921849062821356 1.1588662954770315 0.9824108467878123 0.009368875749476735 0.11719239792614593 0.2104867003037874 0.0070592218165776415 0.017760443205309378 1.2810538050007517e-07 6.8924326292528155 0.16668138919489583 TGVCICFYQHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGVCICFYQHK 11 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 65777600.0 16480000.0 22178000.0 27119600.0 False True 21605439.59254701 18869128.84916692 24313523.941572424 1.0 0.8733508415017852 1.1253427099886266 24.36489124906354 -6.7700466329556255 1.5741239391737267 0.9273620160334406 1.1267675844232297 0.7307912723437917 0.05337739968341729 0.266355230446469 1.3024987232234113 0.026727228898745684 0.06362308969340175 1.698061311049291e-07 6.7700466329556255 0.19940556838978907 TGVCICFYQHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGVCICFYQHK 11 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 49884000.0 16480000.0 15563000.0 17841000.0 False True 22573101.355254278 14875375.20004122 13627323.246928794 1.0 0.6589867721733647 0.603697428743295 24.42810131058643 -13.999999999999998 0.256039477285644 3.4456820461051487 0.58270960309451 0.9995543614015684 0.0036994803629067595 14.245575025611796 0.16011493588311385 17.98366883926739 0.024686613581406447 1.0000000000000041e-14 13.999999999999998 -2.862972443010639 TGVEADEWIK(ub)ILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGVEADEWIKILR 13 1 Q9UN19;J3KNB3;Q9UN19-2 Q9UN19 DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 1 10713800.0 1746100.0 0.0 8967700.0 True False 2260360.8707766933 0.0 7335670.616372349 1.0 0.0 3.2453537447105534 21.10812168927359 -6.823969830325641 1.3546144967302587 0.4630545861255926 3.322425092199284 0.8932746266085059 0.44332823726854964 0.18836853804806408 0.6780774412075433 0.25710581053279163 0.5920533327317555 1.4997890195908096e-07 6.823969830325641 2.8593705060736916 TGVELGKPTHFTVNAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGVELGKPTHFTVNAK 16 1 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 2883900.0 1718800.0 1165100.0 0.0 False True 1664237.634823555 1630330.5059162327 0.0 1.0 0.9796260292413607 0.0 20.66643001849057 -7.039675199858716 1.0648320046922484 1.0158805323136084 9.200050779946996e-19 0.9872075231018234 0.052782895672689546 0.08605376805542422 0.18849836213821825 0.041652957567562654 0.0749121621904694 9.126931691077508e-08 7.039675199858716 -1.0158805323136084 down TGVHHYSGNNIELGTACGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGVHHYSGNNIELGTACGK 19 0 A0A0B4J213;P62888;E5RI99 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 0 65789000.0 15664000.0 27598000.0 22527000.0 False True 20535655.690391775 23480485.976161446 20196122.134242445 1.0 1.1434008404780325 0.9834661448717125 24.291627676596654 -6.670373692458941 1.9361784287021537 1.0915029430260026 0.9841132207709842 0.2806746117383925 0.060908315312785746 0.4602426829400603 3.326714955464566 0.025323032077311923 0.06762063242960492 2.1361232526884374e-07 6.670373692458941 -0.10738972225501842 TGVHHYSGNNIELGTACGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGVHHYSGNNIELGTACGK 19 0 A0A0B4J213;P62888;E5RI99 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 0 32805300.0 17561000.0 7083800.0 8160500.0 False True 17003535.667405408 9912398.281528981 6023020.240247611 1.0 0.5829610073703881 0.3542216370794764 24.01933143171939 -9.643518296582192 0.15012582650258077 1.6251446136466183 5.457353987974624e-11 0.9997735139667129 0.004023431797845027 1.1058175218630855 0.06210715666218695 0.4772642744991631 0.1897328539364771 2.2723838989989612e-10 9.643518296582192 -1.6251446135920449 TGVHHYSGNNIELGTACGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGVHHYSGNNIELGTACGK 19 0 A0A0B4J213;P62888;E5RI99 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 0 142551000.0 32310000.0 80203000.0 30038000.0 False True 49016632.177401096 65890148.02110087 24100976.1338769 1.0 1.344240619849832 0.49168976046029844 25.54676802748861 -6.797143115631291 1.4679496917262902 1.1906270105269678 0.48078684073646083 0.8235586607935816 0.14709880194813224 0.22486615787268308 0.9569706954426828 0.07885050429706456 0.18367302734134672 1.5953533343769088e-07 6.797143115631291 -0.709840169790507 down TGVHHYSGNNIELGTACGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGVHHYSGNNIELGTACGK 19 0 A0A0B4J213;P62888;E5RI99 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 0 56700000.0 15664000.0 18696000.0 22340000.0 False True 21455404.103683442 17869948.9005957 17063752.10674229 1.0 0.8328880133992818 0.795312548031328 24.354837738119546 -13.999999999999998 0.20968932328295065 1.9652360465917564 0.7731138510979341 0.9994898357422364 0.0020094608529683455 12.739427592966173 0.14514306335362698 5.065331466320461 0.022306388547992897 1.0000000000000041e-14 13.999999999999998 -1.1921221954938224 TGVHHYSGNNIELGTACGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGVHHYSGNNIELGTACGK 19 0 A0A0B4J213;P62888;E5RI99 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 0 32407200.0 17561000.0 5177700.0 9668500.0 False True 14602749.584207837 5149806.702407017 11690138.647906916 1.0 0.3526600708113411 0.8005436634035848 23.799736707153667 -9.814875051292264 5.783919504214901 1.0000000591672844 0.5766018671060815 0.5436985391300999 0.1828477110080996 1.3923242328675709e-07 2.87351655657892e-08 0.17704155864722873 0.05901384496807361 1.531528026622253e-10 9.814875051292264 -0.4233981920612029 TGVHHYSGNNIELGTACGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGVHHYSGNNIELGTACGK 19 0 A0A0B4J213;P62888;E5RI99 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 0 97072000.0 32310000.0 32299000.0 32463000.0 False True 41825931.9253164 30501532.25689711 26555067.098508574 1.0 0.7292493162222918 0.634894809897477 25.31789434958106 -13.999999999999998 0.14699133940822373 2.3035082478583075 0.5274074845219185 0.9995765895722795 0.003184146413199422 11.947704727269507 0.12058258287261059 4.4526488757177285 0.09661464432421979 1.0000000000000041e-14 13.999999999999998 -1.776100763336389 TGVHHYSGNNIELGTACGK(ub)YYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGVHHYSGNNIELGTACGKYYR 22 1 A0A0B4J213;P62888;E5RI99 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 1 86395000.0 34188000.0 41296000.0 10911000.0 True False 44820799.07706295 35134797.77054726 9782034.385702467 1.0 0.783894943732217 0.21824765705055055 25.417665034037967 -7.011619902520762 0.5279683387747848 1.0084245973289727 4.007192729198434e-15 0.9994722912327856 0.007571809415828947 0.07507054797659102 0.030254837264113682 0.008662192662889354 0.04249186320307425 9.735989514162973e-08 7.011619902520762 -1.0084245973289687 down TGVHHYSGNNIELGTACGK(ub)YYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGVHHYSGNNIELGTACGKYYR 22 1 A0A0B4J213;P62888;E5RI99 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 1 48839600.0 30340000.0 14382000.0 4117600.0 True False 29376873.30727633 20124807.6011392 3039077.034647825 1.0 0.6850561457183567 0.10345134428908331 24.808177516738386 -7.379527291995391 0.5723848436448329 1.0036144060138736 5.636728830689157e-25 0.9963836161474253 0.022332955166131076 0.10745506352305428 0.07315885447088506 0.021883311441463965 0.06435778364321253 4.173233721467607e-08 7.379527291995391 -1.0036144060138736 down TGVHHYSGNNIELGTACGK(ub)YYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGVHHYSGNNIELGTACGKYYR 22 1 A0A0B4J213;P62888;E5RI99 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 1 113641000.0 51329000.0 50029000.0 12283000.0 True False 77869845.65254776 41100934.071638875 9855259.666169839 1.0 0.5278157896322236 0.12656066778587988 26.2145614308861 -7.943309244611459 0.39837304508731974 1.0585789113764126 1.055231604916343e-18 0.9976345347609478 0.017361697476672974 0.10249255052635976 0.08246158404244264 0.042956553388971856 0.08169983215229197 1.1394381479831122e-08 7.943309244611459 -1.0585789113764126 down TGVHHYSGNNIELGTACGK(ub)YYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGVHHYSGNNIELGTACGKYYR 22 1 A0A0B4J213;P62888;E5RI99 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 1 61532700.0 34188000.0 20436000.0 6908700.0 True False 46828227.49596077 19533069.947185118 5277007.349142819 1.0 0.41712170183827624 0.11268859897799877 25.480875095560858 -8.734995028808223 0.3258817935772282 1.181738816369508 2.7585767232851163e-18 0.998286897614838 0.015237210157238976 0.29536920295928154 0.1037256153900539 0.15481505566207482 0.0898861026840559 1.8407930721557628e-09 8.734995028808223 -1.181738816369508 TGVHHYSGNNIELGTACGK(ub)YYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGVHHYSGNNIELGTACGKYYR 22 1 A0A0B4J213;P62888;E5RI99 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 1 44047500.0 30340000.0 10305000.0 3402500.0 True False 25229054.2898961 10249484.919617644 4113947.0186174978 1.0 0.40625719861891235 0.16306386166306197 24.588582792172662 -9.943857761709728 0.22802748909032794 1.5736594376858954 3.3807047005216168e-15 0.9992295161171394 0.009757517134053439 1.4187310565456601 0.10267063539405649 0.6388861100278725 0.12066170869864297 1.1379999377176729e-10 9.943857761709728 -1.5736594376858921 TGWISTSSIWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGWISTSSIWK 11 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 31355500.0 9210800.0 8046700.0 14098000.0 False True 12075447.997514086 6846163.725790929 12639274.197565153 1.0 0.5669490462962795 1.0466919488342907 23.52557337805954 -6.668933627571053 1.9412714357968042 0.7233327823261526 1.0447398437189488 0.27431716579649723 0.18399575040493293 0.4635474292069441 3.3668571794716713 0.07633414884753008 0.20422092898566552 2.1432181201858823e-07 6.668933627571053 0.3214070613927962 TGWISTSSIWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGWISTSSIWK 11 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 27106200.0 8141300.0 5153900.0 13811000.0 False True 7882858.887822319 7211879.147233432 10193484.778881159 1.0 0.914881168096839 1.2931202909934574 22.91028751820297 -6.847596221334562 1.2466128906676668 0.9546544888260473 1.3075560994366038 0.9367405963057494 0.04074819761466332 0.1601174193869428 0.4800404577266163 0.025592725814770914 0.05914007003922978 1.4203774822707768e-07 6.847596221334562 0.35290161061055647 TGWISTSSIWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGWISTSSIWK 11 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 20355000.0 4262200.0 7640200.0 8452600.0 False True 6466069.008558305 6276746.616844946 6781939.905093811 1.0 0.970720635449022 1.04885052976042 22.6244574739075 -6.805201274132164 1.4345994852850539 0.9839502509881802 1.0500725237854815 0.8469307061790672 0.01260899891316962 0.21341667668185846 0.8665210346268459 0.0069127950448057566 0.01602832576402533 1.5660251262783503e-07 6.805201274132164 0.06612227279730132 TGWISTSSIWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGWISTSSIWK 11 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 32105300.0 9210800.0 8618500.0 14276000.0 False True 12616281.672510695 8237706.172431737 10904302.8234491 1.0 0.6529424743568204 0.8643040086215114 23.588783439582432 -10.330023038717203 5.720668140783157 1.0000354796717605 0.7586232414891646 0.6348915862800286 0.08628798503338392 3.905184608769116e-05 4.573650160714371e-06 0.08356024428096548 0.027849327417673545 4.6771032924773305e-11 10.330023038717203 -0.24141223818259594 TGWISTSSIWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGWISTSSIWK 11 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 20422300.0 8141300.0 5984800.0 6296200.0 False True 6769851.670742631 5952558.6945102075 7612706.309660386 1.0 0.879274611028107 1.124501197354195 22.690692793637247 -6.772869137163437 1.56373746874689 0.9310083657995107 1.1260237076026114 0.7413164090579973 0.05092060150711463 0.26181742917262 1.263908569447284 0.025662661774097265 0.06092177996685088 1.6870612988702123e-07 6.772869137163437 0.19501534180310065 TGYESGEYEMLGEGLGVK(ub)ETPQQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGYESGEYEMLGEGLGVKETPQQK 24 1 Q13561;Q13561-3;Q13561-2;F8W1I6;F8VW18;H0YHL1;F8VX93;F8VRV7 Q13561 DCTN2 Dynactin subunit 2 1 5373200.0 2380000.0 2993200.0 0.0 True False 2304448.2027461324 4188400.3693317925 0.0 1.0 1.8175285364802813 0.0 21.135989909799296 -6.793828946611021 1.5431375102262275 1.4597102579657282 7.869577991540932e-20 0.7823652747182019 0.3467352897228778 0.2376440110557113 1.1275805637427656 0.17854002241356173 0.4060413056466129 1.6075742955615544e-07 6.793828946611021 -1.4597102579657282 TGYNFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGYNFQR 7 0 O43660-2;O43660 O43660-2 PLRG1 Pleiotropic regulator 1 0 3242240.0 845580.0 591760.0 1804900.0 False True 818737.5257470903 828052.8539876336 1332142.5441606417 1.0 1.0113776734882685 1.6270691183295576 19.64304149529651 -6.910904413723792 0.8895555264524759 0.9814778259219928 1.7081949400911989 0.991258330647212 0.02739069070646799 0.10382303633324763 0.135546637579255 0.022525869021612407 0.06257803583421852 1.2277094147843055e-07 6.910904413723792 0.726717114169206 TGYNFQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGYNFQR 7 0 O43660-2;O43660 O43660-2 PLRG1 Pleiotropic regulator 1 0 8117600.0 1986800.0 4281500.0 1849300.0 False True 3014120.8545360737 3517432.8734878185 1483785.0444230144 1.0 1.1669846841722653 0.4922778866646988 21.52330583388576 -6.841213437843275 1.2767622324408356 1.0888205990726763 0.4695492097451059 0.9265230367838484 0.07777367908663574 0.16738176815701722 0.5294959652636616 0.047755765974811425 0.1100574631040594 1.4414067853800117e-07 6.841213437843275 -0.6192713893275703 down TGYNFQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGYNFQR 7 0 O43660-2;O43660 O43660-2 PLRG1 Pleiotropic regulator 1 0 4916300.0 1986800.0 1557500.0 1372000.0 False True 2571951.765683029 1470823.7558474673 1122310.0779088112 1.0 0.5718706608235568 0.436365134402418 21.29443215597821 -13.999999999999998 0.1610052780667089 3.11301870518664 0.30462308738485916 0.9995337591931303 0.0051869231515163745 12.016525899110688 0.12683560436052205 7.928727696632341 0.12022428547421987 1.0000000000000041e-14 13.999999999999998 -2.808395617801781 TGYQAK(ub)QVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGYQAKQVR 9 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 9957590.0 1964390.0 3325200.0 4668000.0 True False 2575334.3131798175 2829093.1215280844 4185000.1386178276 1.0 1.0985343172921678 1.6250317938141876 21.29632829508021 -6.938335696305298 0.6748721658093476 0.993885596660999 1.7603183883966766 0.9979376500023046 0.0124605737908855 0.08853419296839646 0.05812983873879086 0.011981610617435834 0.04565685777562576 1.152562018348931e-07 6.938335696305298 0.7664327917356777 TGYQAK(ub)QVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGYQAKQVR 9 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 9346970.0 1514960.0 3075410.0 4756600.0 True False 1466868.4240471772 4303437.251051284 3510703.765058733 1.0 2.9337581888754856 2.393332426757468 20.48430803850327 -10.17354931600282 5.013005139243566 0.9998803168234381 2.663545307818964 0.9266531776974402 0.22062789351594023 0.000295136682376924 4.865742634167084e-05 0.21363699024693047 0.07120734644010318 6.705801351255873e-11 10.17354931600282 1.663664990995526 TGYQAK(ub)QVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGYQAKQVR 9 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 8583280.0 1964390.0 1980290.0 4638600.0 True False 2690678.0686436845 1892794.2398566857 3543058.214965748 1.0 0.7034636591849148 1.316790089552308 21.359538356603103 -6.775204656324073 1.5542621887807342 0.831051524612358 1.3209634875908176 0.7501758877048599 0.1251734292343799 0.2580864102992576 1.2310273370557665 0.06345111205035382 0.15034731604160842 1.67801308723893e-07 6.775204656324073 0.4899119629784596 TGYQAK(ub)QVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGYQAKQVR 9 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 7771000.0 1514960.0 3526200.0 2729840.0 True False 1259756.364107482 3507203.6607040996 3300636.9226459363 1.0 2.7840332945560466 2.6200597327280715 20.264713313937545 -9.811841240682712 10.627552893012195 0.999999981775879 2.7020465208241626 0.9930872083608178 0.0669419262975425 0.0 0.0 0.06481624142835654 0.021605413809452176 1.5422641351139548e-10 9.811841240682712 1.7020465390482835 TGYSANIIFHTKPFYGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGYSANIIFHTKPFYGGK 18 1 Q96SU4-3;Q96SU4-7;Q96SU4-2;Q96SU4;Q96SU4-6;Q96SU4-5;Q96SU4-4 Q96SU4-3 OSBPL9 Oxysterol-binding protein-related protein 9 0 31367800.0 8342100.0 9671300.0 13354400.0 False True 10936573.885011328 8228379.738432143 11972614.79245029 1.0 0.7523727105898503 1.0947317613662233 23.38265751813289 -6.71267189179962 1.7857104185997417 0.8481817824701463 1.0939916078292475 0.4777791275127099 0.10430619067016308 0.36972526985927934 2.2998081978873617 0.04645526876658748 0.11763609597457192 1.9378854778006114e-07 6.71267189179962 0.24580982535910123 TGYSANIIFHTKPFYGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGYSANIIFHTKPFYGGK 18 1 Q96SU4-3;Q96SU4-7;Q96SU4-2;Q96SU4;Q96SU4-6;Q96SU4-5;Q96SU4-4 Q96SU4-3 OSBPL9 Oxysterol-binding protein-related protein 9 0 16774700.0 5899400.0 1862800.0 9012500.0 False True 5712126.7761682905 2606625.754373668 6651855.880795488 1.0 0.4563319156796095 1.1645147493133146 22.445596568530057 -6.70169353911582 1.8257489517644216 0.6629471942913527 1.1624119218981415 0.4252312753874109 0.22942031407479135 0.3919931835903751 2.5416992124959363 0.10022397493872769 0.2571243224413129 1.9874969043307917e-07 6.70169353911582 0.4994647276067887 TGYSANIIFHTKPFYGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGYSANIIFHTKPFYGGK 18 1 Q96SU4-3;Q96SU4-7;Q96SU4-2;Q96SU4;Q96SU4-6;Q96SU4-5;Q96SU4-4 Q96SU4-3 OSBPL9 Oxysterol-binding protein-related protein 9 0 110936000.0 28951000.0 28707000.0 53278000.0 False True 43920783.6016075 23584011.561185244 42747579.94742303 1.0 0.5369670034831089 0.9732881893723424 25.388400458264766 -10.601854975688786 9.467570165332903 1.000041636468868 0.7551275964277256 0.2957538006413093 0.17812737823244498 0.00015657372468678597 6.5844746791410085e-06 0.1725002753750705 0.05749036411648739 2.5011804434881645e-11 10.601854975688786 -0.24491404004114237 TGYSANIIFHTKPFYGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGYSANIIFHTKPFYGGK 18 1 Q96SU4-3;Q96SU4-7;Q96SU4-2;Q96SU4;Q96SU4-6;Q96SU4-5;Q96SU4-4 Q96SU4-3 OSBPL9 Oxysterol-binding protein-related protein 9 0 29655700.0 8342100.0 8593500.0 12720100.0 False True 11426399.806775909 8213810.755095697 9715874.358682754 1.0 0.7188450337808825 0.85030057787066 23.445867579655783 -10.083534407996755 4.741071705851638 1.0000094884067317 0.7845728058473723 0.7816982676133568 0.0536665011584781 74591243.4113262 1.2259289774619064 7925.975961860861 0.018371470790016074 8.250221185811866e-11 10.083534407996755 -0.21543668255935933 TGYSANIIFHTKPFYGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGYSANIIFHTKPFYGGK 18 1 Q96SU4-3;Q96SU4-7;Q96SU4-2;Q96SU4;Q96SU4-6;Q96SU4-5;Q96SU4-4 Q96SU4-3 OSBPL9 Oxysterol-binding protein-related protein 9 0 12926000.0 5899400.0 3120200.0 3906400.0 False True 4905612.487732795 3103390.863288789 4723210.178847136 1.0 0.6326204670771028 0.9628176279023705 22.226001843964333 -10.314362827544873 8.043915736517194 1.0000006176570109 0.797719048800036 0.3335032561150295 0.13480242642293677 1.4931609652208369e-06 1.2742340782734937e-07 0.13052228683510964 0.043507296047032074 4.848832394178903e-11 10.314362827544873 -0.2022815688569749 TGYSANIIFHTKPFYGGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGYSANIIFHTKPFYGGK 18 1 Q96SU4-3;Q96SU4-7;Q96SU4-2;Q96SU4;Q96SU4-6;Q96SU4-5;Q96SU4-4 Q96SU4-3 OSBPL9 Oxysterol-binding protein-related protein 9 0 95721000.0 28951000.0 37566000.0 29204000.0 False True 37477640.20952752 35475419.07683201 23889171.658344742 1.0 0.9465755815600548 0.6374246490650621 25.159526780357215 -6.9366058668634185 0.6904175207383725 1.0037567217021583 0.5617708972955326 0.9976846705280914 0.007690320714102941 0.08934981723311927 0.06192021313697711 0.007305811318501006 0.02702978714305364 1.1571619192850066e-07 6.9366058668634185 -0.4419858244066257 TGYSASITFHTKPFYGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGYSASITFHTKPFYGGK 18 1 Q9BXB4 Q9BXB4 OSBPL11 Oxysterol-binding protein-related protein 11 0 15902500.0 5407700.0 4400200.0 6094600.0 False True 8203876.255825808 3614949.93108048 4889999.63864192 1.0 0.4406392561703256 0.5960596535289511 22.967874300238375 -10.61247748468425 9.901066852337816 1.0000701206164195 0.5183494548497202 0.9275635963226592 0.06345011152487313 9.822553553026326e-05 3.844506543676316e-06 0.061444092897666454 0.02047843543756974 2.4407456013867235e-11 10.61247748468425 -0.48172066576669936 TGYSASITFHTKPFYGGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGYSASITFHTKPFYGGK 18 1 Q9BXB4 Q9BXB4 OSBPL11 Oxysterol-binding protein-related protein 11 0 21323700.0 5407700.0 9701900.0 6214100.0 False True 7000374.251703294 9161980.736344485 5083197.562050399 1.0 1.308784417363863 0.7261322579737194 22.739000622330824 -6.762720594977814 1.6021583777770068 1.178753197912319 0.7237080625671745 0.7019816829636331 0.12993166463541767 0.2783813380115101 1.4089359406657853 0.06396759531069067 0.15331848213516955 1.726948573665844e-07 6.762720594977814 -0.45504513534514446 TGYSFVNCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGYSFVNCK 9 0 P43897;C9JT21;P43897-2;C9JG32;F8VPA7;F8VS27;P43897-4;P43897-3;F8WCK2;A0A494C1M9 P43897 TSFM Elongation factor Ts, mitochondrial;Elongation factor Ts 0 5062900.0 1078200.0 2485600.0 1499100.0 False True 1413530.6413036513 2114758.1687929146 1343987.5123826012 1.0 1.4960822970505578 0.9508018242484557 20.430871726336694 -6.667253864747625 1.9470319544434596 1.3173958080524288 0.9530294820020561 0.2669068642804002 0.2108601647283179 0.4674964473898112 3.4140110107184727 0.08726679781218022 0.23399956198716088 2.1515237042538213e-07 6.667253864747625 -0.3643663260503728 TGYTLDVTTGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TGYTLDVTTGQR 12 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;F6UXX1;O43390;O43390-2;O43390-4 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 284404000.0 70282000.0 69412000.0 144710000.0 False True 92140382.61185624 59056000.16585686 129736797.35633807 1.0 0.6409350438084439 1.408034063661942 26.457330252940306 -6.779423448324437 1.5381051836965876 0.7965344215425672 1.4140016552844397 0.7653362124329595 0.15180763275877437 0.2514782410342058 1.1750808633768266 0.07773929889732561 0.18352160838908782 1.6617915705465942e-07 6.779423448324437 0.6174672337418725 TGYTLDVTTGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TGYTLDVTTGQR 12 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;F6UXX1;O43390;O43390-2;O43390-4 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 181329000.0 50142000.0 34920000.0 96267000.0 False True 48550269.65634317 48863738.10539432 71051784.75190447 1.0 1.0064565748299648 1.463468385548327 25.53297597284856 -6.909977024745791 0.895890628112552 0.9858396000936527 1.5225005652500014 0.9909128571412195 0.0206834941165935 0.10443338567256902 0.13884964608374636 0.016931906236825493 0.046732323662406226 1.2303338568003686e-07 6.909977024745791 0.5366609651563488 TGYTLDVTTGQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TGYTLDVTTGQR 12 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;F6UXX1;O43390;O43390-2;O43390-4 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 250265000.0 50711000.0 123920000.0 75634000.0 False True 76932294.47069585 101805507.8086208 60684906.74844013 1.0 1.3233130314006085 0.788809266199067 26.197086000921434 -6.742942057304346 1.6758342520777358 1.1917130921208154 0.7882859323517284 0.6180867178494783 0.13583742380862615 0.3125332628918084 1.7244840984113625 0.06409386422519989 0.15678103008488356 1.8074152516303374e-07 6.742942057304346 -0.40342715976908705 TGYTLDVTTGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TGYTLDVTTGQR 12 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;F6UXX1;O43390;O43390-2;O43390-4 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 228357000.0 70282000.0 52505000.0 105570000.0 False True 96267154.6996349 50185155.48918352 80636540.28239869 1.0 0.5213112992252368 0.8376329448397472 26.520540314463197 -9.885298333859442 5.394147341838428 1.0000003111721918 0.6794721220299699 0.5778860633332938 0.1291377710676953 40372591.41422405 73986686.11849427 96.83968706205106 0.04420729365951727 1.3022718896438806e-10 9.885298333859442 -0.3205281891422219 TGYTLDVTTGQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TGYTLDVTTGQR 12 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;F6UXX1;O43390;O43390-2;O43390-4 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 108532000.0 50142000.0 30634000.0 27756000.0 False True 41695294.66723704 30468968.561627064 33559651.27075599 1.0 0.7307531654301678 0.8048786209232908 25.313381248282838 -9.903234915436789 6.209285833620438 1.000000035950471 0.767815893176689 0.9289865703342378 0.03026159048506685 1.5056057397859026e-08 2.636861079497904e-09 0.029300663578977627 0.00976688633151321 1.2495829319979534e-10 9.903234915436789 -0.23218414277378208 TGYTLDVTTGQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TGYTLDVTTGQR 12 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;F6UXX1;O43390;O43390-2;O43390-4 O60506;O43390;O43390-2 SYNCRIP;HNRNPR Heterogeneous nuclear ribonucleoprotein Q;Heterogeneous nuclear ribonucleoprotein R 0 197977000.0 50711000.0 85160000.0 62106000.0 False True 65646389.16325337 80420771.13834363 50803345.26137363 1.0 1.2250600857626526 0.7738939781597558 25.968212323013883 -6.7710832053562635 1.5704424006881172 1.1289093742568783 0.771259387906352 0.7346514173418752 0.09487889467288484 0.26467463402330293 1.2884243248457725 0.04761802735421254 0.1132321471007668 1.694013217745383e-07 6.7710832053562635 -0.35764998635052636 THAVILSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 THAVILSR 8 0 Q96FV2-2;Q96FV2;J3KT79;J3QR84;J3QRJ1;J3QL71 Q96FV2-2 SCRN2 Secernin-2 0 2652570.0 641490.0 791380.0 1219700.0 False True 840999.602197997 673309.1887750785 1093497.144188553 1.0 0.8006058350269718 1.3002350314205147 19.68174559250687 -6.798432974616475 1.4625630880818705 0.8897654940132214 1.3068476101002164 0.8274635831091605 0.08529848055904861 0.22300649548022314 0.9419728561518282 0.045887183442227336 0.10680779617853454 1.5906221482195196e-07 6.798432974616475 0.4170821160869951 THAVILSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 THAVILSR 8 0 Q96FV2-2;Q96FV2;J3KT79;J3QR84;J3QRJ1;J3QL71 Q96FV2-2 SCRN2 Secernin-2 0 2576800.0 787320.0 503580.0 1285900.0 False True 762326.9575571794 704662.1201350079 949084.2138268984 1.0 0.9243568171759867 1.2449831459039162 19.540050368319672 -6.844499342761925 1.2612304016587959 0.9597488650921204 1.2565101393871163 0.9319218573375088 0.03570540172796508 0.16361853044586613 0.5036021258033045 0.022179506842798805 0.051179221668345286 1.4305421457245103e-07 6.844499342761925 0.2967612742949959 THAVILSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THAVILSR 8 0 Q96FV2-2;Q96FV2;J3KT79;J3QR84;J3QRJ1;J3QL71 Q96FV2-2 SCRN2 Secernin-2 0 1953400.0 641490.0 737030.0 574880.0 False True 878666.1886154172 704465.5775677161 439105.18402524677 1.0 0.8017442649953305 0.4997406178985663 19.744955654029763 -6.964999730107561 0.3580566642669175 1.0266082567913373 0.26455847746666916 0.9999131395260691 0.0019169897862105487 0.07796105643918116 0.014860247905427545 0.004068218416721142 0.02582523638356251 1.0839275876281265e-07 6.964999730107561 -0.7620497793246681 down THAVLVALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 THAVLVALK 9 0 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 114879000.0 37248000.0 44034000.0 33597000.0 False True 48832488.71014508 37464298.84318764 30120704.725180585 1.0 0.7672002765528584 0.6168169085947678 25.541337969901242 -8.994493434108252 0.08013042926646192 1.690586957050282 6.559935594730359e-08 0.9999851350740993 0.0006077366264932748 0.4733024072767934 0.02548511530239914 0.29691638188259656 0.22814002807107978 1.0127600601365313e-09 8.994493434108252 -1.690586891450926 THAVLVALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 THAVLVALK 9 0 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 74618000.0 36406000.0 12320000.0 25892000.0 False True 35250311.45763684 17239440.24795128 19110108.45664984 1.0 0.4890578135364652 0.5421259463087583 25.07113266885497 -10.817571193285678 11.004934188699854 1.0047598620192024 0.5155918802885816 0.9910789834329955 0.02166497448239797 0.002518354744998483 4.174669246798482e-05 0.02087942319304652 0.0069923404471946655 1.5220496049702765e-11 10.817571193285678 -0.4891679817306208 THAVLVALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 THAVLVALK 9 0 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 80580000.0 23708000.0 34335000.0 22537000.0 False True 35966769.28696456 28207650.98942058 18082552.07168201 1.0 0.7842698009477288 0.5027571958829139 25.100161239503496 -6.9674688017390904 0.31279488433638764 1.0419625523568152 0.23607960809553258 0.9999553668053202 0.0013601321200788646 0.07713287874750291 0.011955722208075215 0.004398982204375441 0.024926197094788778 1.077782675210789e-07 6.9674688017390904 -0.8058829442612827 THAVLVALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THAVLVALK 9 0 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 89746000.0 37248000.0 22909000.0 29589000.0 False True 51019592.1893514 21896804.63006776 22600687.604583625 1.0 0.42918423473086814 0.44298056167725985 25.604548031424134 -10.101688082354052 5.542731069254828 1.000005917170605 0.4360823982039174 0.9995512933979612 0.005632326891061419 4.1183933595985936e-07 6.675388674632355e-08 0.005453534239772188 0.0018178256873814555 7.912467107490638e-11 10.101688082354052 -0.5639235189666876 THAVLVALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THAVLVALK 9 0 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 73808000.0 36406000.0 23992000.0 13410000.0 False True 30273202.059260286 23862750.33396089 16213968.99916552 1.0 0.7882466574645512 0.5355881735743186 24.851537944289245 -6.968780942080173 0.28580568048433835 1.0519110796238784 0.2641629837343715 0.9999712506768855 0.0010178769711370185 0.07670025772625494 0.010439105077368366 0.004516274070032696 0.023025732312462372 1.0745312687091356e-07 6.968780942080173 -0.7877480958895069 THAVLVALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THAVLVALK 9 0 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 77277000.0 23708000.0 36946000.0 16623000.0 False True 30690473.35454661 34889922.62185585 13597784.566383505 1.0 1.136832339429757 0.44306206715345675 24.871287561595945 -6.855498141649018 1.2083788055240525 1.0735178692769451 0.4122609027012273 0.9479124660938033 0.06847738375528244 0.15151702519514157 0.4230096427085156 0.04427391531138169 0.10287266509729788 1.3947676258536137e-07 6.855498141649018 -0.6612569665757179 down THAVLVALK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 THAVLVALKR 10 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 1 10627600.0 3550200.0 3823400.0 3254000.0 True False 4654346.5801857 3252963.6234964747 2917307.294572069 1.0 0.6989087656997575 0.6267920199564669 22.150147212576766 -13.999999999999996 0.2007485132506172 2.678509622258478 0.5803000226436805 0.9994869759773118 0.0036610966425700505 12.545796326936047 0.14206619870932524 8.271122562461342 0.045665227557972726 1.0000000000000082e-14 13.999999999999996 -2.0982095996147976 THAVLVALK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 THAVLVALKR 10 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 1 19219970.0 3534300.0 6745170.0 8940500.0 True False 3422105.581078011 9438551.556596862 6598714.840749181 1.0 2.758112317979268 1.9282616168348883 21.70645284082534 -9.83296822060382 6.299834196424827 0.999999940303234 2.343186967407513 0.7774368029398134 0.3387851300839859 2.843423329991463e-07 5.198473250530766e-08 0.32802730635252014 0.10934243056293719 1.4690337699102425e-10 9.83296822060382 1.343187027104279 THAVLVALK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 THAVLVALKR 10 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 1 16773660.0 2002000.0 5272160.0 9499500.0 True False 3037180.3658049214 4331301.856425911 7621919.661221241 1.0 1.4260930648674264 2.50953803963541 21.53430115617188 -6.9550973247185315 0.49976247126637147 0.9782572269229818 3.0040848417339037 0.9995429593232635 0.013584866378633898 0.08150121216054775 0.02797411920867202 0.01593866780686082 0.08937368851324391 1.1089262787592424e-07 6.9550973247185315 2.0258276148109218 up THAVLVALK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THAVLVALKR 10 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 1 10078300.0 3550200.0 3246200.0 3281900.0 True False 4862804.880547553 3102772.150252125 2506782.8128521764 1.0 0.6380622349590864 0.5155014183028277 22.213357274099657 -13.999999999999998 0.1511984272345306 2.7534284320490934 0.38250056673464133 0.9995622883822942 0.004303258805524883 11.962373944351189 0.1225212611856846 6.160350532294089 0.12002016664809466 1.0000000000000041e-14 13.999999999999998 -2.370927865314452 THAVLVALK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THAVLVALKR 10 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 1 18473750.0 3534300.0 12533750.0 2405700.0 True False 2938927.0460375706 12466228.200995428 2908720.747299957 1.0 4.241761706131191 0.989721997768424 21.486858116259615 -6.646919231639864 2.0196657151543773 3.1087135719890715 1.0034153452738026 0.18159297078868963 1.3846788483443655 0.5161308129104407 4.03186089852387 0.5567243622899132 1.5334009912967173 2.2546584855800126e-07 6.646919231639864 -2.105298226715269 THAVLVALK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THAVLVALKR 10 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 1 10636100.0 2002000.0 5408100.0 3226000.0 True False 2591628.4653198216 5107134.480898028 2638901.1015552715 1.0 1.9706275607170332 1.018240514359228 21.305427478264328 -6.641759543853207 2.037898815360137 1.6338834969742109 1.022199830469804 0.1614333533900274 0.4151200659800541 0.5289711348157111 4.200695880525771 0.16575021585612784 0.4597384633375889 2.2816049802662916e-07 6.641759543853207 -0.611683666504407 THAVLVALKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 THAVLVALKR 10 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 29186650.0 10190000.0 8025650.0 10971000.0 False True 13359188.680100383 6828254.303738672 9835826.161263093 1.0 0.5111279185621446 0.7362592442394627 23.671329058046137 -10.351081650251311 5.875394446530488 1.0000579282431914 0.6236935814008034 0.788368951979245 0.09190947883763065 6.97519050131638e-05 7.703769763141484e-06 0.08900461395343526 0.029663656741395192 4.4557246993421923e-11 10.351081650251311 -0.37636434684238795 THAVLVALKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 THAVLVALKR 10 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 24634100.0 8154000.0 2598100.0 13882000.0 False True 7895155.733273947 3635534.8789125173 10245887.748926815 1.0 0.46047665197921833 1.297743590509021 22.91253629309254 -6.732736276293169 1.7134111434667327 0.6763030222864683 1.297483072256009 0.5718035294187465 0.22675842632570145 0.3311483644764762 1.905825414529321 0.10482768135825701 0.2593051713140059 1.850391921486425e-07 6.732736276293169 0.6211800499695406 THAVLVALKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 THAVLVALKR 10 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 63036000.0 13601000.0 22636000.0 26799000.0 False True 20633711.366290085 18596428.944124784 21502165.903581023 1.0 0.9012643733354887 1.0420891095098752 24.298500004978834 -6.718229976577832 1.7655320715340346 0.939818124446755 1.0418504472159265 0.5042315080802783 0.04155751846661665 0.35876232762532423 2.184521472709809 0.018696119975649204 0.04703495492173969 1.9132425170577383e-07 6.718229976577832 0.1020323227691714 THAVLVALKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THAVLVALKR 10 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 28416900.0 10190000.0 8815000.0 9411900.0 False True 13957518.374395715 8425524.152693147 7189003.064165082 1.0 0.6036548852516145 0.5150631273645969 23.73453911956903 -13.999999999999998 0.21052864950475988 3.2971998804352225 0.46314926171890036 0.9994903145248745 0.004760085613206562 12.75913785198874 0.145427672949719 12.127046382069427 0.052283794686234855 1.0000000000000041e-14 13.999999999999998 -2.834050618716322 THAVLVALKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THAVLVALKR 10 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 16720880.0 8154000.0 4561500.0 4005380.0 False True 6780412.283448026 4536926.2941131415 4842886.439215321 1.0 0.6691224817093261 0.7142466028264258 22.692941568526816 -10.424986290703547 6.860218981463083 1.0000350165906033 0.6916845422681854 0.9841887352675199 0.01842184530474027 9.867284929229411e-06 8.270552533647277e-07 0.017838895280273007 0.005945625005972356 3.758492684680102e-11 10.424986290703547 -0.3083504743224179 THAVLVALKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THAVLVALKR 10 1 P25786;P25786-2;F5GX11;B4DEV8 P25786 PSMA1 Proteasome subunit alpha type-1;Proteasome subunit alpha type 0 78676000.0 13601000.0 35671000.0 29404000.0 False True 17606762.615791664 33685877.49267095 24052773.71051799 1.0 1.913235171493582 1.3661099564632537 24.069626327071283 -10.131364210580845 4.578599523237493 0.9999338855259948 1.6396725639916212 0.6457111089769825 0.2233629337526131 155962727.1222095 15.350497680704004 110864.02474367873 0.0764630733222642 7.389852829597359e-11 10.131364210580845 0.6397386784656264 THCFNWHSPTYEYALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THCFNWHSPTYEYALR 16 0 Q99538 Q99538 LGMN Legumain 0 10113400.0 3800700.0 2439200.0 3873500.0 False True 5205921.500055515 2331428.078644255 2958659.0772366333 1.0 0.4478415739882734 0.5683257185505165 22.3117221268721 -9.817270766258707 6.459035629968286 1.0000000112875815 0.5080836462694781 0.9569448170292341 0.04918744604590395 7.987880385270976e-09 1.4832902129906738e-09 0.047625540908915444 0.01587517994813435 1.523102860426531e-10 9.817270766258707 -0.49191636501810343 THEAQIQEMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 THEAQIQEMR 10 0 P35579 P35579 MYH9 Myosin-9 0 16110090.0 1964590.0 7655700.0 6489800.0 False True 2575596.515116621 6513499.401684867 5818297.750557408 1.0 2.5289284883932766 2.259009793035832 21.29647517239108 -10.073006117132634 4.503916666570928 0.9999127082452047 2.3939691405748382 0.9726487662927862 0.11019384625784297 19124858.72017487 3.6769548235426592 18473.62884441794 0.03772228451122183 8.452669393069833e-11 10.073006117132634 1.3940564323296334 THEAQIQEMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 THEAQIQEMR 10 0 P35579 P35579 MYH9 Myosin-9 0 15114720.0 5106600.0 3387690.0 6620430.0 False True 4944493.778211513 4740412.283569967 4886340.774357269 1.0 0.9587255027924488 0.9882388356699927 22.2373913934333 -10.013949126962475 4.425084033868181 1.0000011474280837 0.9734821692272686 0.5183997685668771 0.012048767706409547 1.3654611658907582e-07 3.0409231468723895e-08 0.011666674533924538 0.003888723053914438 9.683912864865527e-11 10.013949126962475 -0.026518978200815058 THEAQIQEMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 THEAQIQEMR 10 0 P35579 P35579 MYH9 Myosin-9 0 45133300.0 6912600.0 32659500.0 5561200.0 False True 10486919.578752797 26831157.055161834 4462026.382439447 1.0 2.5585355979580084 0.4254849433078338 23.32208762800869 -6.710815384572346 1.7922150177844967 1.9573475472125719 0.4303562490700126 0.4690123579377169 0.6566744318521437 0.37343913356290825 2.3387035920837262 0.2915205508074464 0.7398909142551637 1.946187215845727e-07 6.710815384572346 -1.5269912981425593 THEAQIQEMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 THEAQIQEMR 10 0 P35579 P35579 MYH9 Myosin-9 0 15344320.0 1964590.0 6325530.0 7054200.0 False True 2690952.014048482 6046047.168869541 5388143.245809386 1.0 2.246806014118917 2.0023185912197055 21.35968523391397 -10.193096859207323 4.951711350203674 0.9998863860334656 2.1245623026711433 0.9657643606364068 0.09981157244486263 0.00012520263894181177 2.0402242588838735e-05 0.09665173774691864 0.03221404648557103 6.41066585760601e-11 10.193096859207323 1.1246759166376776 THEAQIQEMR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 THEAQIQEMR 10 0 P35579 P35579 MYH9 Myosin-9 0 9688830.0 5106600.0 2554480.0 2027750.0 False True 4246364.160737752 2540718.5092154215 2451743.1497433167 1.0 0.598327984374756 0.5773746802999952 22.017796668867575 THEAQIQEMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 THEAQIQEMR 10 0 P35579 P35579 MYH9 Myosin-9 0 18042070.0 6912600.0 4901030.0 6228440.0 False True 8948496.967717182 4628283.372148387 5094927.82919123 1.0 0.5172134928184584 0.5693612958211661 23.093213950101138 -10.852119981942208 11.163829651543567 1.0102031828162978 0.5432873943198122 0.9903167431423057 0.021289251427301727 0.0051715519089627175 6.850405064191177e-05 0.019717664273621868 0.006871076352596844 1.4056591309574156e-11 10.852119981942208 -0.46691578849648563 THEDIEAQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 THEDIEAQIR 10 0 O75533;B4DGZ4;A0A494C1M2;O75533-2;F8WC19 O75533 SF3B1 Splicing factor 3B subunit 1 0 4513700.0 1427200.0 1862000.0 1224500.0 False True 1871073.0210244611 1584196.8580191538 1097800.486233404 1.0 0.8466782644066798 0.5867224175101031 20.835434432025902 -6.963141662777521 0.3886288421904492 1.0162114785229046 0.4078692103187978 0.9998695640390145 0.0019481802112078655 0.078597354750434 0.017119571497742556 0.003359056938438221 0.021879863800657866 1.0885749524981507e-07 6.963141662777521 -0.6083422682041069 THEDIEAQIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 THEDIEAQIR 10 0 O75533;B4DGZ4;A0A494C1M2;O75533-2;F8WC19 O75533 SF3B1 Splicing factor 3B subunit 1 0 4409980.0 1306900.0 810680.0 2292400.0 False True 1265413.1748608924 1134388.7516403515 1691951.6694741284 1.0 0.8964572000485577 1.3370744853040792 20.271177091000435 -6.844768351140465 1.2600789835124748 0.9449041688488746 1.3529887613916234 0.9323458222021601 0.04892939009695611 0.16330055239655664 0.5015997148509623 0.03042176330785598 0.07020146120475973 1.4296563212904285e-07 6.844768351140465 0.40808459254274876 THEDIEAQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THEDIEAQIR 10 0 O75533;B4DGZ4;A0A494C1M2;O75533-2;F8WC19 O75533 SF3B1 Splicing factor 3B subunit 1 0 5159200.0 1427200.0 1896400.0 1835600.0 False True 1954874.4086297895 1812610.777443818 1402069.085368675 1.0 0.9272262041193291 0.7172169624704501 20.898644493548794 -6.952319848800416 0.5327661413316498 1.0032477617700992 0.6316165556184155 0.9993709908659796 0.0030068845490503174 0.08256735549777211 0.032208882100808967 0.003341106214807802 0.017373061673574774 1.1160410041832873e-07 6.952319848800416 -0.37163120615168377 THEDIEAQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THEDIEAQIR 10 0 O75533;B4DGZ4;A0A494C1M2;O75533-2;F8WC19 O75533 SF3B1 Splicing factor 3B subunit 1 0 3809260.0 1306900.0 1693100.0 809260.0 False True 1086745.2554866595 1683978.934245964 978472.5244045252 1.0 1.5495618000115907 0.9003697227703578 20.05158236643471 -6.682351158797136 1.8934269607162317 1.346978476950331 0.9027889756944366 0.33493168678160135 0.23279881335001024 0.43334104066947393 3.0056097875967476 0.09858174340523987 0.2592323580643483 2.0780157801498536e-07 6.682351158797136 -0.4441895012558944 THESK(ub)DCESESYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 THESKDCESESYK 13 1 O94901-3;H0Y742;O94901-9 O94901-3 SUN1 1 4397300.0 1858400.0 1528300.0 1010600.0 True False 2436380.396771198 1300283.5972667413 906032.8063597213 1.0 0.5336948199837497 0.3718765786986454 21.216307970914404 -13.999999999999998 0.14761202190677017 3.2469017706369363 0.18886213756030423 0.999574405131 0.005493423548402051 11.949511617605836 0.12087170692763853 7.707037855212182 0.16459178767444488 1.0000000000000041e-14 13.999999999999998 -3.058039633076632 THESK(ub)DCESESYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THESKDCESESYK 13 1 O94901-3;H0Y742;O94901-9 O94901-3 SUN1 1 4050700.0 1858400.0 1065600.0 1126700.0 True False 2545500.7013716344 1018518.2685320271 860596.665114885 1.0 0.4001249215854476 0.33808541661416763 21.279518032437295 -13.999999999999998 0.32060072685544794 7.172768004830875 0.3258510771284415 0.9996950143733297 0.00521265876312569 18.06016068028506 0.18059982146077952 74.7992871096499 0.020606866994289003 1.0000000000000041e-14 13.999999999999998 -6.846916927702433 THESK(ub)DCESESYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THESKDCESESYK 13 1 O94901-3;H0Y742;O94901-9 O94901-3 SUN1 1 2180020.0 822520.0 718270.0 639230.0 True False 683961.8238142834 714400.536944567 772890.0375344204 1.0 1.0445035264695544 1.1300192651458334 19.383556275964843 -6.960820021941084 0.42372087006016146 0.9963680817193301 1.1814003368376356 0.999799396680444 0.0007641414270051316 0.07940952088428331 0.020058732405118497 0.001109096080189285 0.007111425724467863 1.0944098119267423e-07 6.960820021941084 0.18503225511830546 THFDYQFGYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 THFDYQFGYR 10 0 Q6PKG0-3;Q6PKG0;A0A0B4J210;E5RH50 Q6PKG0-3 LARP1 La-related protein 1 0 11647400.0 4029900.0 3112400.0 4505100.0 False True 5283237.925607109 2648042.0520401755 4038955.467970688 1.0 0.5012157486236781 0.7644848717477667 22.332990951079736 -10.02701238309257 5.1163779869224735 1.0000038607416513 0.6328503101838909 0.7216915430307358 0.10747916945370926 4.733256321397832e-06 9.001875770522149e-07 0.10406735292163351 0.034688752778952385 9.396965164990154e-11 10.02701238309257 -0.36715355055776033 THFDYQFGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 THFDYQFGYR 10 0 Q6PKG0-3;Q6PKG0;A0A0B4J210;E5RH50 Q6PKG0-3 LARP1 La-related protein 1 0 10699800.0 3624900.0 2290700.0 4784200.0 False True 3509829.5336699444 3205388.4558426887 3531074.4970764797 1.0 0.9132604376062314 1.006052990096166 21.74296953236081 -11.120521353370703 10.204551960762622 1.6849165864353521 0.9596567138511827 0.20129812485801224 0.03788240092179411 0.04278409365946201 0.0005053044846928229 0.00265849427511794 0.012226492323705082 7.576674789909738e-12 11.120521353370703 -0.7252598725841695 THFDYQFGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THFDYQFGYR 10 0 Q6PKG0-3;Q6PKG0;A0A0B4J210;E5RH50 Q6PKG0-3 LARP1 La-related protein 1 0 12072400.0 4029900.0 2255400.0 5787100.0 False True 5519862.933952619 2155748.970389578 4420306.169065723 1.0 0.3905439312866971 0.8007999876005011 22.396201012602628 -10.090087117870654 5.945178478440469 1.000001574488079 0.5956719594436435 0.5642852614890493 0.1674863336426187 3.4954065719365925e-06 5.34908515830214e-07 0.16216857827383765 0.05405598174292437 8.126674817142574e-11 10.090087117870654 -0.40432961504443554 THGVHMVLNHQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 THGVHMVLNHQGR 13 0 H0YBR2;H0YBB3;A0A2U3TZN9;Q6NXG1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1 H0YBR2 ESRP1 Epithelial splicing regulatory protein 1 0 8824600.0 1911700.0 2595500.0 4317400.0 False True 2506257.212929137 2208261.51717976 3870676.8634251496 1.0 0.8810993164579861 1.5444052763049707 21.25710305292849 -6.860535693685925 1.182926385124347 0.93538941440218 1.5768711604938102 0.95429485532981 0.06173529563604979 0.14625620502875386 0.388570446505079 0.04069369266026483 0.09505551880675482 1.3786826374896157e-07 6.860535693685925 0.6414817460916301 THGVHMVLNHQGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 THGVHMVLNHQGR 13 0 H0YBR2;H0YBB3;A0A2U3TZN9;Q6NXG1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1 H0YBR2 ESRP1 Epithelial splicing regulatory protein 1 0 6712800.0 1628700.0 1001600.0 4082500.0 False True 1576997.8100053081 1401544.103274997 3013170.77762525 1.0 0.8887419464902615 1.9107006734620056 20.58874922596707 -6.8799290235170965 1.0802371386693077 0.9311159866654977 1.983015626629646 0.9736263193406681 0.07434515253540247 0.12769101619551854 0.27268919707709804 0.053020850928476825 0.12819040467523052 1.3184721980587408e-07 6.8799290235170965 1.0518996399641483 THGVHMVLNHQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THGVHMVLNHQGR 13 0 H0YBR2;H0YBB3;A0A2U3TZN9;Q6NXG1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1 H0YBR2 ESRP1 Epithelial splicing regulatory protein 1 0 6182300.0 1911700.0 1566400.0 2704200.0 False True 2618507.1517499797 1497191.2686078886 2065523.654747203 1.0 0.5717728391947671 0.7888172668792556 21.32031311445138 -10.484696554027742 7.311377499981224 1.0000545970075163 0.6802950530370171 0.7431250588933636 0.08860801655689998 7.887135720508554e-05 5.5588044921003605e-06 0.08580892169286863 0.02859811437211204 3.275694910739476e-11 10.484696554027742 -0.3197595439704992 THGVHMVLNHQGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THGVHMVLNHQGR 13 0 H0YBR2;H0YBB3;A0A2U3TZN9;Q6NXG1-2;Q6NXG1-5;Q6NXG1-4;Q6NXG1-3;Q6NXG1 H0YBR2 ESRP1 Epithelial splicing regulatory protein 1 0 4145950.0 1628700.0 1690500.0 826750.0 False True 1354336.2136438317 1681392.9409620205 999619.6025399008 1.0 1.2414885787025107 0.7380882180285437 20.369154501401347 -6.776251718963563 1.5503175433622187 1.1374054647351923 0.7345496663482097 0.7539270719811287 0.10197387467753356 0.2564584657869789 1.217179602178986 0.05181915564104783 0.1226680836804338 1.6739723531645562e-07 6.776251718963563 -0.4028557983869826 THHNDTELIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 THHNDTELIR 10 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 14501900.0 3250000.0 5217600.0 6034300.0 False True 4260781.473044766 4439154.4180455115 5409928.521092871 1.0 1.0418639036357993 1.2697033526168902 22.022686629796137 -6.9379328628906425 0.678519525695818 0.9973281145260153 1.3275803310421204 0.997880457284071 0.005456055688129058 0.08872236968694318 0.05899928504738533 0.0052313097269049815 0.019794901628574595 1.153631582682885e-07 6.9379328628906425 0.33025221651610503 THHNDTELIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 THHNDTELIR 10 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 19893100.0 5844600.0 4958100.0 9090400.0 False True 5659066.3721722895 6937895.186149932 6709351.533845581 1.0 1.2259787621976153 1.1855933633925784 22.43213262744503 -10.103169896951062 4.552820840022497 0.9999830055023077 1.2057860628016535 0.9719255565598647 0.016487270044194455 11480166.712998418 0.18296754192946033 2045.2779235789112 0.0056440310684680705 7.885515741707854e-11 10.103169896951062 0.20580305729934578 THHNDTELIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THHNDTELIR 10 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 14366000.0 3250000.0 5295300.0 5820700.0 False True 4451612.827947594 5061336.136784571 4445970.541079449 1.0 1.136966832562141 0.9987325297400702 22.08589669131903 -6.648332172048454 2.0148433531668415 1.0889980551821172 0.9993176523282016 0.18714339678691427 0.05848368848080624 0.5126540069560637 3.987321995230316 0.02355818602814168 0.06475922956458642 2.2473350641920774e-07 6.648332172048454 -0.08968040285391565 THHNDTELIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THHNDTELIR 10 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 11950100.0 5844600.0 3976200.0 2129300.0 False True 4860043.859681172 3954779.421386092 2574526.7852291637 1.0 0.8137332780460818 0.5297332410078409 22.212537902879305 -6.964984480804935 0.358319766954851 1.0249468443184866 0.308812695849086 0.999912822950426 0.0018053920330303843 0.07796624118497603 0.014878598555639196 0.0038235620070640295 0.024281792165244575 1.0839656480472497e-07 6.964984480804935 -0.7161341484694006 THIDVIHYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 THIDVIHYR 9 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 62834000.0 22395000.0 13131000.0 27308000.0 False True 29360061.873488486 11171905.984237123 24482430.116832834 1.0 0.3805137071024063 0.8338684782861425 24.80735167273602 -9.8167400135098 6.189579782968529 1.0000000186337052 0.6071910926940819 0.5002446550170556 0.1850813103103086 4.760352506664137e-08 9.0599642729221e-09 0.17920421614215548 0.059734736043705314 1.5249653874300562e-10 9.8167400135098 -0.39280892593962335 THIDVIHYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 THIDVIHYR 9 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 48766300.0 11468000.0 8711300.0 28587000.0 False True 11103954.617265819 12189767.518829376 21099207.108382884 1.0 1.097786143674903 1.9001524984238676 23.404570240844514 -6.929626694600061 0.7498463828826247 0.9876285721711271 2.0633212766676086 0.9964645035901469 0.023978353007697725 0.09283174884229434 0.07863187338502742 0.02179727459698785 0.07274966295948639 1.1759078927982653e-07 6.929626694600061 1.0756927044964815 THIDVIHYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 THIDVIHYR 9 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 89063000.0 20059000.0 39932000.0 29072000.0 False True 30430969.5093311 32805822.609859966 23325906.457289718 1.0 1.078040665112581 0.7665186759868842 24.85903696204771 -6.840350799944598 1.280750133812507 1.0415135940635352 0.7561998534045875 0.9250631180057836 0.03623041381018306 0.16838460414651668 0.5363767378255727 0.022180566252616465 0.05110502998485566 1.444272692922835e-07 6.840350799944598 -0.28531374065894766 THIDVIHYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THIDVIHYR 9 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 56888000.0 22395000.0 16092000.0 18401000.0 False True 30675036.702118903 15381002.23087215 14055062.780490832 1.0 0.5014175656979636 0.45819220746099276 24.87056173425891 -13.99999999999938 0.3462593665568325 6.991876261750059 0.45192118800981035 0.9997475177276754 0.003906578743727829 20.29316384246871 0.18916506275304143 89.27557827712464 0.013064089133449617 1.0000000000014275e-14 13.99999999999938 -6.539955073740249 THIDVIHYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THIDVIHYR 9 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 37737600.0 11468000.0 17026000.0 9243600.0 False True 9536150.11854082 16934277.558603615 11176394.022422526 1.0 1.7757981311219988 1.1720027352225333 23.18497551627879 -10.09743601379416 4.566641641820127 0.999966727709009 1.4739004326581926 0.4509596107122489 0.24649843822135875 171540657.69700044 5.7582730290665145 64592.02800900869 0.08438297186894161 7.990316572729319e-11 10.09743601379416 0.47393370494918363 THIDVIHYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THIDVIHYR 9 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 74406000.0 20059000.0 27854000.0 26493000.0 False True 25966770.922003124 26303900.414366182 21671545.841135688 1.0 1.0129831118923374 0.8345876314860603 24.63016328414016 -6.889398732722795 1.0259576382033275 1.009724061728292 0.8194248965574734 0.9805097500717712 0.011337444441405033 0.11963137149242305 0.22472033600144783 0.008426709212058356 0.02096248271911417 1.290034328550213e-07 6.889398732722795 -0.19029916517081868 THIETVINALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 THIETVINALK 11 0 O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O94973 AP2A2 AP-2 complex subunit alpha-2 0 3228210.0 962010.0 1139500.0 1126700.0 False True 1261204.426118091 969491.0417362119 1010119.8920695585 1.0 0.7687025367649916 0.8009168626046175 20.266370707515 -10.375930137990053 8.666414562591974 1.0000008401842782 0.7848096997289881 0.9834699131131197 0.013151443452473127 2.1348885681681708e-07 1.5392119489525713e-08 0.012733880078270823 0.004244610122501409 4.207943132696073e-11 10.375930137990053 -0.2151911404552901 THIFK(ub)IHAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 THIFKIHAR 9 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 9297160.0 987360.0 1677800.0 6632000.0 True False 956016.7972535386 2347754.2896114117 4894880.244264706 1.0 2.4557667776926935 5.120077657972958 19.866676441075356 -6.961742936855835 0.41013928537072425 0.8689532190367358 6.80578752803289 0.9998294621810156 0.022278218286508323 0.07908439379809927 0.018874089377345502 0.03430911171827574 0.2224397409573264 1.092086561875113e-07 6.961742936855835 5.936834308996154 THIFK(ub)IHAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THIFKIHAR 9 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 6678360.0 987360.0 3190500.0 2500500.0 True False 821033.5874644633 3173312.143235338 3023342.988994285 1.0 3.8650211047214778 3.6823621288515724 19.647081716509632 -10.218252262309175 4.264920424996622 0.9987161087543596 3.773691616884727 0.9967579726256656 0.07457021503272313 5343695.670305616 4268337.470110241 57568.318995735164 0.025527367299928237 6.049893613173473e-11 10.218252262309175 2.7749755081303675 THILLFLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 THILLFLPK 9 0 P07237;H7BZ94;I3L398;I3L312;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 899212270.0 301912270.0 279850000.0 317450000.0 False True 395809909.6925819 238097470.84675622 284603319.19542146 1.0 0.6015449967679739 0.7190404086054023 28.560232491962783 -10.495642071340233 9.122837131773585 1.0000085100015044 0.6602927026866892 0.9176662158574421 0.047967301019977676 8.302656888171044e-06 4.590605849570101e-07 0.04644530140772269 0.015481379834407638 3.1941692809681635e-11 10.495642071340233 -0.3397158073148152 THILLFLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 THILLFLPK 9 0 P07237;H7BZ94;I3L398;I3L312;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 1117520000.0 422410000.0 204990000.0 490120000.0 False True 409000825.76554424 286843576.0087281 361742868.71517175 1.0 0.7013276207250456 0.8844551060210752 28.607528515045026 -10.34442057229647 5.620527380503171 1.0000428049757277 0.7928913640648314 0.6303698744419594 0.07476148280905592 4.010905837574766e-05 4.678299442230178e-06 0.07240243285141557 0.024129164821436316 4.524592045982794e-11 10.34442057229647 -0.20715144091089632 THILLFLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 THILLFLPK 9 0 P07237;H7BZ94;I3L398;I3L312;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 693210000.0 185530000.0 244710000.0 262970000.0 False True 281462574.0598333 201039588.57204342 210993864.23615438 1.0 0.7142675691202428 0.7496338187801171 28.06836785970667 -10.1898706316517 7.957421121437706 1.0000000958681041 0.7319506940645107 0.9871122671720687 0.014438210963761876 2.4552390896377115e-08 2.500060280982936e-09 0.01397974275657867 0.0046599125509732605 6.458465862174232e-11 10.1898706316517 -0.2680494018035934 THILLFLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THILLFLPK 9 0 P07237;H7BZ94;I3L398;I3L312;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 1008512270.0 301912270.0 279260000.0 427340000.0 False True 413537395.0913169 266921369.8106736 326411093.34356576 1.0 0.6454588459931956 0.7893145752187369 28.623442553485674 -10.115376753963204 5.063012429386207 1.0000093828352001 0.7173867113852487 0.8372924804374703 0.05872885553200847 81885193.79257539 6.52052004218243 8957.070930894202 0.020104449344246544 7.666960857485529e-11 10.115376753963204 -0.28262267144995146 THILLFLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THILLFLPK 9 0 P07237;H7BZ94;I3L398;I3L312;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 768060000.0 422410000.0 155560000.0 190090000.0 False True 351252630.9358941 154721967.40375748 229836940.1231449 1.0 0.44048628758027797 0.6543351419482796 28.387933790479302 -10.176526718378362 5.366941385779528 1.0000172254839745 0.5474107147641717 0.8565729854500942 0.08730342921377715 1.799485257893221e-05 2.7609677532590978e-06 0.08453439505685573 0.028177060617590777 6.65998546915175e-11 10.176526718378362 -0.45260651071980285 THILLFLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THILLFLPK 9 0 P07237;H7BZ94;I3L398;I3L312;I3L4M2 P07237 P4HB Protein disulfide-isomerase 0 770110000.0 185530000.0 326190000.0 258390000.0 False True 240172242.34304985 308037239.7559457 211365671.30529013 1.0 1.2825680301388072 0.8800586997201205 27.839494181799118 -6.717973570892438 1.7662360860866018 1.1722734011818277 0.8807389886945692 0.5031672863746474 0.11893536277914382 0.3592380046802129 2.188975453101817 0.053486543428673664 0.13461114094223212 1.9143724211251816e-07 6.717973570892438 -0.2915344124872584 THIMK(ub)SADVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THIMKSADVEK 11 1 O75663;O75663-2 O75663 TIPRL TIP41-like protein 1 1753250.0 729260.0 417000.0 606990.0 True False 998887.1295104811 398575.56116540456 463631.4633514551 1.0 0.39901961832337574 0.4641479999633836 19.92996214254943 -10.206808054493532 5.4170052414007515 1.0000287039400146 0.4315838091465875 0.990249795189252 0.026588550465469075 9.21762424645466e-06 1.349706950839763e-06 0.025745549651145904 0.00858141776267578 6.211435009008923e-11 10.206808054493532 -0.5684448947934271 THINIVVIGHVDSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 THINIVVIGHVDSGK 15 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 181017700.0 73369700.0 65522000.0 42126000.0 False True 96188387.21318556 55746373.00275556 37767205.62112561 1.0 0.5795540877424527 0.39263789232083574 26.51935939270538 -13.999999999999998 0.1097993369266737 3.029409718275674 0.04875451482671628 0.9997440817120168 0.00406319735501206 12.01384988009589 0.10051869481166549 5.406973914331718 0.3054557427486779 1.0000000000000041e-14 13.999999999999998 -2.9806552034489577 THINIVVIGHVDSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 THINIVVIGHVDSGK 15 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 255293500.0 85119400.0 75614100.0 94560000.0 False True 82417331.23900394 105807204.45232235 69791899.26080681 1.0 1.283797993233845 0.8468109584671658 26.296444412583764 -6.731399750707348 1.717975297424931 1.1705194127177136 0.8469961974480934 0.5658159359512084 0.1192893178561981 0.333617288868781 1.9296233984900255 0.05500931202752136 0.13629397188104125 1.8560952071343347e-07 6.731399750707348 -0.32352321526962025 THINIVVIGHVDSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 THINIVVIGHVDSGK 15 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 1462400700.0 314616700.0 771717600.0 376066400.0 False True 477296535.461707 633998564.822871 301736711.20424134 1.0 1.32831168407619 0.6321787165548143 28.830310623479054 -6.778463031580022 1.5419611587514932 1.1862677263561578 0.6269358183155987 0.7618948605275382 0.1387503207680165 0.2529608560569599 1.1878921720446334 0.07088203747842693 0.16746088401734868 1.6654705914924296e-07 6.778463031580022 -0.5593319080405591 THINIVVIGHVDSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THINIVVIGHVDSGK 15 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 264152300.0 73369700.0 138130000.0 52652600.0 False True 100496460.83158989 132026959.86517328 40217140.294335745 1.0 1.3137473575952252 0.4001846429371367 26.58256945422827 -6.813995463055274 1.3977116854452514 1.1701977881026189 0.3827029705287078 0.8700036355115734 0.13665079207757175 0.20139586819161792 0.7746593377569604 0.07685951348122924 0.17748888516826652 1.534633014568252e-07 6.813995463055274 -0.7874948175739112 down THINIVVIGHVDSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THINIVVIGHVDSGK 15 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 161005400.0 85119400.0 46051000.0 29835000.0 False True 70780552.52878657 45802914.1225922 36073360.558546096 1.0 0.6471115650582705 0.5096507341317377 26.07684968801804 -13.99999999999854 0.13040138522240083 2.6771061014084077 0.31812401482695435 0.9996438026820174 0.0038977557432268 11.936168260121669 0.11233693717998809 5.128976054744117 0.17035686340936262 1.0000000000033621e-14 13.99999999999854 -2.3589820865814533 THINIVVIGHVDSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THINIVVIGHVDSGK 15 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 0 1541683100.0 314616700.0 777139400.0 449927000.0 False True 407277520.17232114 733890909.2295644 368044902.640873 1.0 1.8019430802835656 0.9036710459373043 28.601436945571503 -6.67128876142955 1.9329026597589765 1.5113089075076032 0.9072874405713982 0.2847522656428483 0.3405469485505555 0.4581484879063382 3.3012393123325507 0.14177954087767344 0.3781504107504208 2.1316271277486058e-07 6.67128876142955 -0.604021466936205 THISK(ub)GTLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 THISKGTLGK 10 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 2424580.0 649800.0 951340.0 823440.0 True False 851894.0926721522 809403.7802942746 738238.3277942301 1.0 0.9501225413541753 0.8665846308178803 19.700314560435082 -6.963362113568533 0.38516101990501483 1.0054154724737048 0.8083133865160252 0.9998752385844556 0.0006147669212029104 0.07852164568012712 0.016849915694156413 0.0010820876485651452 0.00704193243519752 1.0880225247731037e-07 6.963362113568533 -0.19710208595767953 THISK(ub)GTLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 THISKGTLGK 10 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 4196700.0 1326900.0 1374000.0 1495800.0 True False 1284778.285808338 1922645.365315345 1104005.1069618745 1.0 1.4964802772220602 0.859296206323469 20.293087984336438 -6.698813590274537 1.8354346431690038 1.3086608696306523 0.8612550796632567 0.41178226969243203 0.20961740584603245 0.39800301047422476 2.6059550683149957 0.09114670412670245 0.23472007327502128 2.000720443101017e-07 6.698813590274537 -0.44740578996739566 THISK(ub)GTLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THISKGTLGK 10 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 2401110.0 649800.0 836500.0 914810.0 True False 890048.620184724 799540.6640644135 698750.7191033532 1.0 0.898311222479592 0.7850702795970089 19.763524621957973 -6.969735393584866 0.2644373300404013 1.0301185752117716 0.6498836567675635 0.9999802377684701 0.00039021172489627165 0.07638871717820364 0.009337297717387373 0.002297890462535676 0.010614926319377164 1.0721723581455861e-07 6.969735393584866 -0.3802349184442081 THISK(ub)GTLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THISKGTLGK 10 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 3343340.0 1326900.0 1378900.0 637540.0 True False 1103376.1416368869 1371471.592009781 770846.6663480961 1.0 1.2429773857310051 0.6986254616712351 20.073493259770714 -6.785365035049233 1.514883333402595 1.1366210937212655 0.6935579814142622 0.7859471705398478 0.10301395281451863 0.2423224103106496 1.0986244650410248 0.05354143279335931 0.12578539539488953 1.639211397050336e-07 6.785365035049233 -0.44306311230700335 THLMSESEWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 THLMSESEWR 10 0 P61024;Q5T179;Q9BZU3 P61024 CKS1B Cyclin-dependent kinases regulatory subunit 1;Cyclin-dependent kinases regulatory subunit 0 8376700.0 2513600.0 2638300.0 3224800.0 False True 3295353.9417370255 2244675.9240128524 2891128.630465889 1.0 0.6811638335970834 0.8773347815081545 21.652001997399793 -10.347004422064574 5.72944401380316 1.0000400496510216 0.779249308725016 0.6280305524822997 0.0800864541233735 4.097815003851841e-05 4.670371183142083e-06 0.07755742227999499 0.025847791923052015 4.497752751771755e-11 10.347004422064574 -0.2207907409260056 THLMSESEWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 THLMSESEWR 10 0 P61024;Q5T179;Q9BZU3 P61024 CKS1B Cyclin-dependent kinases regulatory subunit 1;Cyclin-dependent kinases regulatory subunit 0 5148800.0 2380200.0 0.0 2768600.0 False True 2304641.8538556076 0.0 2043420.6037803462 1.0 0.0 0.8866542974396456 21.136111139583065 -9.122062211425305 12.127664416882679 0.9998851845742118 0.4433271462827572 0.34450707172031125 0.3619751072319246 0.0 0.0 0.35048088777011643 0.11682696259003879 7.549840706399692e-10 9.122062211425305 -0.5565580382914546 THLMSESEWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THLMSESEWR 10 0 P61024;Q5T179;Q9BZU3 P61024 CKS1B Cyclin-dependent kinases regulatory subunit 1;Cyclin-dependent kinases regulatory subunit 0 6457500.0 2513600.0 1829000.0 2114900.0 False True 3442945.847485872 1748188.7323058152 1615404.1777327328 1.0 0.5077595784965331 0.46919244428788875 21.715212058922685 -13.999999999999998 0.361063093682898 7.483404172846517 0.464619051111659 0.9997752086942385 0.00362303714480458 21.81209463551488 0.19428256417246131 109.02295313070368 0.011090631627554906 1.0000000000000041e-14 13.999999999999998 -7.018785121734858 THLMSESEWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THLMSESEWR 10 0 P61024;Q5T179;Q9BZU3 P61024 CKS1B Cyclin-dependent kinases regulatory subunit 1;Cyclin-dependent kinases regulatory subunit 0 4932550.0 2380200.0 1587300.0 965050.0 False True 1979241.760738652 1578748.89984562 1166837.4931129504 1.0 0.7976533898801891 0.5895376281255743 20.91651641501734 -6.970773359616508 0.23899677480061088 1.0756643870799565 0.3055146734476739 0.9999878002357597 0.0005852839491696284 0.07605255546678633 0.008127034141992917 0.005010275350283295 0.020325581295421 1.0696129204820858e-07 6.970773359616508 -0.7701497136322826 THLMSESEWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THLMSESEWR 10 0 P61024;Q5T179;Q9BZU3 P61024 CKS1B Cyclin-dependent kinases regulatory subunit 1;Cyclin-dependent kinases regulatory subunit 0 11497100.0 3059700.0 5862800.0 2574600.0 False True 3960841.9657038176 5536530.026184601 2106049.2176268427 1.0 1.3978164425958846 0.5317175579997195 21.917375709384242 -6.781814074568649 1.5287978675626392 1.2247222565934628 0.5244612831965347 0.7737610218363303 0.16836591532917344 0.24776434613956494 1.1438993648247815 0.08673025407106652 0.2043392816726354 1.6526691695569505e-07 6.781814074568649 -0.700260973396928 THLPGFVEQAEALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 THLPGFVEQAEALK 14 0 P30044-2;P30044 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 11026200.0 2961600.0 3252000.0 4812600.0 False True 2867585.6290978757 4550540.558955968 3552035.685094743 1.0 1.5868891630578925 1.2386851325559862 21.4514051365872 -10.295012861129957 5.12033253766332 0.9998986187641064 1.4127871478070253 0.6520288022120134 0.1421537001853289 0.0001645591409911852 2.2657057179897468e-05 0.13767333293474462 0.04587990945158551 5.069756945521949e-11 10.295012861129957 0.41288852904291895 THLQLGSVLYHHTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 THLQLGSVLYHHTK 14 0 Q9Y6X3;V9GYS3 Q9Y6X3 MAU2 MAU2 chromatid cohesion factor homolog 0 6373600.0 2541700.0 1304100.0 2527800.0 False True 3332193.3138578096 1109533.363341985 2266247.504369781 1.0 0.33297388801774985 0.6801068518278905 21.668040668963407 -10.638545861387838 6.723607009120324 1.0018322133743993 0.5065403699231271 0.7293146931962609 0.14171643903914397 0.0039035525062680364 0.0002098506757902573 0.1376148931934486 0.04573878402353525 2.2985509700444835e-11 10.638545861387838 -0.4952918434512722 THLSLSHNPEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 THLSLSHNPEQK 12 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 18883900.0 5979900.0 5032900.0 7871100.0 False True 7839706.809433976 4282010.93809055 7056674.076922616 1.0 0.5461952904843018 0.9001196407537727 22.902368270541576 -10.122832908566062 7.579801120725847 1.0000000621556642 0.7231574656190376 0.44927843000232637 0.14448901095104494 1.5177707659473358e-07 1.7327004976559583e-08 0.13990091455096748 0.04663362776028156 7.536454672100366e-11 10.122832908566062 -0.2768425965366266 THLSLSHNPEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 THLSLSHNPEQK 12 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 16930200.0 4082500.0 3922300.0 8925400.0 False True 3952903.2721475177 5488494.844524284 6587569.983739471 1.0 1.388471831121361 1.6665143390064796 21.91448122205305 -6.9747432501924065 0.08940222577277887 0.17684453369511882 2.8851520045529666 0.9999998401757378 0.00010912547401196909 0.07479157292315747 0.0026070456906892472 0.029044831955485788 0.049529133997074634 1.0598801287076984e-07 6.9747432501924065 2.708307470857848 THLSLSHNPEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 THLSLSHNPEQK 12 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 26556700.0 4860200.0 15793000.0 5903500.0 False True 7373278.728214323 12974615.758727813 4736670.6374040255 1.0 1.759680630148921 0.6424103593532755 22.813874864773744 -6.723620585283444 1.7462069380954026 1.460393498338677 0.643785159445193 0.529519547930164 0.3195446507890436 0.34836262037956933 2.0778192746558863 0.14518891466309844 0.3629466659276462 1.8896414844990817e-07 6.723620585283444 -0.816608338893484 THLSLSHNPEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THLSLSHNPEQK 12 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 18400900.0 5979900.0 5458500.0 6962500.0 False True 8190830.630721184 5217325.421154342 5318100.897188593 1.0 0.6369714692409612 0.6492749193521471 22.965578332064467 -10.122503169694436 5.430606159083838 1.000006126020484 0.6431231942964307 0.9991093808007356 0.005022862475132572 3.7255288429206497e-07 6.01999961090767e-08 0.004863449135854068 0.00162112189297713 7.542178911748727e-11 10.122503169694436 -0.3568829317240533 THLSLSHNPEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THLSLSHNPEQK 12 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 12336800.0 4082500.0 5003900.0 3250400.0 False True 3394779.6354153226 4976942.997503618 3930043.6118484414 1.0 1.4660577510194504 1.1576726721372692 21.694886497487325 -10.398232936596035 5.412107530278096 0.9998273610138996 1.3118652115783636 0.5769159463439963 0.1258976812582273 0.0002623994835096746 2.9175985774334876e-05 0.12196681659017929 0.04063330190326841 3.997302943788486e-11 10.398232936596035 0.312037850564464 THLSLSHNPEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THLSLSHNPEQK 12 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 16621700.0 4860200.0 6189500.0 5572000.0 False True 6291624.708864831 5845048.883992222 4557953.173548034 1.0 0.9290205876006259 0.7244477197004341 22.585001186866194 -6.9523479409342706 0.5324421636162083 1.003170899794839 0.6409716862214799 0.9993728993222253 0.0029253384622068813 0.08255638375175282 0.03216461061404264 0.003252020530857344 0.01692258588630464 1.1159688159317408e-07 6.9523479409342706 -0.36219921357335905 THNDIIHNENMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 THNDIIHNENMR 12 0 P15311;E7EQR4 P15311 EZR Ezrin 0 33333500.0 6669600.0 16688200.0 9975700.0 False True 8743910.188498285 14198385.610094106 8943510.257671347 1.0 1.6238027729025195 1.0228273238025267 23.059847152027316 -10.14942592310726 4.228429140266955 0.9999270033125853 1.323315048345638 0.27844829730087406 0.24534719986671144 35162843.95163095 42200409.0471713 21257.26190713846 0.08398887237529996 7.088822090078099e-11 10.14942592310726 0.32338804503305263 THNDIIHNENMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 THNDIIHNENMR 12 0 P15311;E7EQR4 P15311 EZR Ezrin 0 14549200.0 0.0 4618700.0 9930500.0 False True 0.0 6462970.996202315 7329404.141385814 0.0 THNDIIHNENMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 THNDIIHNENMR 12 0 P15311;E7EQR4 P15311 EZR Ezrin 0 58945200.0 9053200.0 41094000.0 8798000.0 False True 13734366.27757496 33760454.63111256 7059071.443699605 1.0 2.458100646859518 0.5139713985366353 23.711287008240713 -6.70599261864868 1.8094573206691809 1.9000524606011406 0.519050139160376 0.4460696122952016 0.6148347595227074 0.38318676321837647 2.443044296482565 0.27066011946348384 0.6909743868358994 1.9679197365594034e-07 6.70599261864868 -1.3810023214407647 THNDIIHNENMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 THNDIIHNENMR 12 0 P15311;E7EQR4 P15311 EZR Ezrin 0 27499600.0 6669600.0 10262000.0 10568000.0 False True 9135531.359162873 9808590.908104017 8072056.054791975 1.0 1.0736749207550003 0.8835891134778668 23.123057213550208 -6.801653866190581 1.4495791049594555 1.0405648909364893 0.8808697702064382 0.8368301812747885 0.031609828879388784 0.21841259145865302 0.9059594723919412 0.017155048861397442 0.039849136411979506 1.578869131096597e-07 6.801653866190581 -0.1596951207300511 THNDIIHNENMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THNDIIHNENMR 12 0 P15311;E7EQR4 P15311 EZR Ezrin 0 3206300.0 0.0 0.0 3206300.0 False True 0.0 0.0 3876722.5057438016 0.0 THNDIIHNENMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THNDIIHNENMR 12 0 P15311;E7EQR4 P15311 EZR Ezrin 0 31013200.0 9053200.0 11092000.0 10868000.0 False True 11719545.865251435 10474720.449348383 8890135.515096912 1.0 0.8937821115070703 0.7585733796610881 23.482413330333163 -6.967841159640658 0.3053826676119496 1.0219990801963859 0.6260870427834095 0.9999603052501815 0.0006224415907746941 0.07700961501082759 0.011524416277150588 0.0021854263877393336 0.012058918982057859 1.0768589957311904e-07 6.967841159640658 -0.3959120374129763 THNGESVSYLFSHVPL ddPTM_RPMI8226_Bortezomib_1h_R1 1 THNGESVSYLFSHVPL 16 0 B1ALA9;P60891;P60891-2;B7ZB02;P11908;P11908-2;H7C540 B1ALA9;P11908 PRPS1;PRPS2 Ribose-phosphate pyrophosphokinase 1;Ribose-phosphate pyrophosphokinase 2 0 20879800.0 4342500.0 9259100.0 7278200.0 False True 5693059.552829821 7877678.371689112 6525121.681424227 1.0 1.3837337021660687 1.1461537721278212 22.440772760590715 -10.161349463016053 4.148344108418922 0.9999237856545047 1.264943736890014 0.62379998187269 0.09699160063938289 67924632.60563888 9.729978500281208 57048.12915687613 0.03320280466941506 6.896846131312244e-11 10.161349463016053 0.26501995123550937 THNGESVSYLFSHVPL ddPTM_RPMI8226_Bortezomib_2h_R1 1 THNGESVSYLFSHVPL 16 0 B1ALA9;P60891;P60891-2;B7ZB02;P11908;P11908-2;H7C540 B1ALA9;P11908 PRPS1;PRPS2 Ribose-phosphate pyrophosphokinase 1;Ribose-phosphate pyrophosphokinase 2 0 32185100.0 7800900.0 9018200.0 15366000.0 False True 7553264.699496778 12619214.289291738 11341183.6298811 1.0 1.6706966843267745 1.5014942652064989 22.848668915450375 -10.08264795364144 4.518015580837979 0.9999617278306853 1.586095474667022 0.9411691209778741 0.06907659847513098 10690238.813568309 11928459.707868027 3613.545589013111 0.023646756641052334 8.267078211995604e-11 10.08264795364144 0.5861337468363367 THNGESVSYLFSHVPL ddPTM_RPMI8226_Bortezomib_8h_R1 1 THNGESVSYLFSHVPL 16 0 B1ALA9;P60891;P60891-2;B7ZB02;P11908;P11908-2;H7C540 B1ALA9;P11908 PRPS1;PRPS2 Ribose-phosphate pyrophosphokinase 1;Ribose-phosphate pyrophosphokinase 2 0 35900900.0 8294900.0 21171000.0 6435000.0 False True 12583969.738419188 17392869.640222017 5163119.429439301 1.0 1.382144903537167 0.41029337615745864 23.585083770728993 -6.800032684762983 1.4557390191201103 1.210835224235168 0.3968596994883268 0.8322799612417993 0.16371691403142039 0.2207044084732932 0.9233686825724315 0.08847366963872513 0.20575672457870164 1.5847739187625822e-07 6.800032684762983 -0.8139755247468413 down THNGESVSYLFSHVPL ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THNGESVSYLFSHVPL 16 0 B1ALA9;P60891;P60891-2;B7ZB02;P11908;P11908-2;H7C540 B1ALA9;P11908 PRPS1;PRPS2 Ribose-phosphate pyrophosphokinase 1;Ribose-phosphate pyrophosphokinase 2 0 27609400.0 4342500.0 8981900.0 14285000.0 False True 5948039.601649985 8585049.958828645 10911177.208809929 1.0 1.4433410894653684 1.8344156965234681 22.503982822113606 -6.972602133169106 0.18580024297158804 0.719955828690268 2.5684383733931813 0.9999962074262023 0.0006638061108922225 0.07546705539360976 0.005898410949707216 0.014314156363212096 0.04314024460875709 1.0651183499966144e-07 6.972602133169106 1.8484825447029132 THNGESVSYLFSHVPL ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THNGESVSYLFSHVPL 16 0 B1ALA9;P60891;P60891-2;B7ZB02;P11908;P11908-2;H7C540 B1ALA9;P11908 PRPS1;PRPS2 Ribose-phosphate pyrophosphokinase 1;Ribose-phosphate pyrophosphokinase 2 0 19335200.0 7800900.0 6745400.0 4788900.0 False True 6486793.988465747 6709061.191342936 5790236.848628171 1.0 1.034264569411701 0.8926191981622765 22.62907419088465 -6.842797457626104 1.2692561185557938 1.0182273106804354 0.8876939814536068 0.9291667705483456 0.01605916377547547 0.1655599877070141 0.516877421970486 0.009915971694081722 0.022865622702268416 1.4361590602042997e-07 6.842797457626104 -0.1305333292268286 THNGESVSYLFSHVPL ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THNGESVSYLFSHVPL 16 0 B1ALA9;P60891;P60891-2;B7ZB02;P11908;P11908-2;H7C540 B1ALA9;P11908 PRPS1;PRPS2 Ribose-phosphate pyrophosphokinase 1;Ribose-phosphate pyrophosphokinase 2 0 24683400.0 8294900.0 9333800.0 7054700.0 False True 10737911.56692376 8814365.824930396 5770816.987334771 1.0 0.8208640730550895 0.5374245216463464 23.356210092821442 -6.964354784538505 0.36895862260139733 1.0220556665093035 0.3263829498198645 0.9998992197158436 0.0019117984834375475 0.07818060002295575 0.015636151018624228 0.0037419645905403 0.02408588282050366 1.0855384614899375e-07 6.964354784538505 -0.695672716689439 THPSVVPGSIAFSLPQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 THPSVVPGSIAFSLPQR 17 0 I3L0N3;P46459;I3L0L3 I3L0N3 NSF Vesicle-fusing ATPase 0 14807100.0 4233700.0 4295300.0 6278100.0 False True 5550421.699209125 3654457.982948264 5628502.435787606 1.0 0.658410870559436 1.0140675323083301 22.404165955245634 -10.981280176487838 11.769836357255059 1.0986008566275067 0.8362392014338148 0.2203829782954504 0.1451962241510704 0.07451143158898631 0.00011850969905251385 0.02788405106259219 0.046861879839107896 1.0440464560082028e-11 10.981280176487838 -0.2623616551936919 THPSVVPGSIAFSLPQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 THPSVVPGSIAFSLPQR 17 0 I3L0N3;P46459;I3L0L3 I3L0N3 NSF Vesicle-fusing ATPase 0 9892900.0 2559000.0 1426400.0 5907500.0 False True 2477765.9457257814 1995968.9585777356 4360148.528798812 1.0 0.8055518569140239 1.7597096030479376 21.240608483643438 -6.853623708453259 1.2174331651636578 0.8958170743153793 1.8006140758856506 0.9454196160269404 0.09618046724885912 0.1535156788790802 0.4360240166687526 0.06175606425199735 0.14328231456028223 1.4008005111432866e-07 6.853623708453259 0.9047970015702713 THPSVVPGSIAFSLPQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THPSVVPGSIAFSLPQR 17 0 I3L0N3;P46459;I3L0L3 I3L0N3 NSF Vesicle-fusing ATPase 0 15528600.0 4233700.0 3936800.0 7358100.0 False True 5799013.301440542 3762859.1587433163 5620268.324826341 1.0 0.6488792080902072 0.969176656903029 22.467376016768526 -10.383329182716801 8.249782300178051 1.0000015616002882 0.8090279332810961 0.32157049980578756 0.13076088591777119 3.7557317516481386e-06 2.80831996737929e-07 0.12660971902140836 0.04220289445790467 4.136859938781247e-11 10.383329182716801 -0.19097362831919207 THPVEIFYTPEPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 THPVEIFYTPEPER 14 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 6978300.0 1227600.0 3095200.0 2655500.0 False True 1609395.4880953098 2633408.224995101 2380734.3333546785 1.0 1.6362716588150072 1.479272404430706 20.61808746257208 -10.052777322151385 4.680012455839588 0.9999804410230436 1.55777203158939 0.9439114473501696 0.06409467726548455 44406834.1811385 1.421762136118976 9848.085252996227 0.021941312837570743 8.855695556798174e-11 10.052777322151385 0.5577915905663463 THPVEIFYTPEPER ddPTM_RPMI8226_Bortezomib_2h_R1 1 THPVEIFYTPEPER 14 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 5103300.0 1292900.0 884400.0 2926000.0 False True 1251857.5971976803 1237545.5320850734 2159592.8218815615 1.0 0.9885673377350229 1.7251106089988775 20.255639029756672 -6.903378175984361 0.9396917692133449 0.9721499164036392 1.8079458081523816 0.9881724094464918 0.03747108583687161 0.10896084218690966 0.1637397972081385 0.029707070956192523 0.07868623846029127 1.2491708005529958e-07 6.903378175984361 0.8357958917487424 THPVEIFYTPEPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THPVEIFYTPEPER 14 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 5885000.0 1227600.0 1952100.0 2705300.0 False True 1681476.894642606 1865849.7672685503 2066363.8574024164 1.0 1.1096493643257181 1.2288981573199775 20.681297524094973 -6.970051199710637 0.256964630417195 0.965255384651874 1.3768161142649673 0.9999827742217191 0.0003879138339815995 0.07628613710673597 0.008970891165967231 0.0025390114656508385 0.011303311355628926 1.0713929894612679e-07 6.970051199710637 0.4115607296130933 THSDQFLVAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 THSDQFLVAFK 11 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 39974000.0 14934000.0 13894000.0 11146000.0 False True 19578618.621061716 11821069.358387802 9992718.839981627 1.0 0.6037744330783008 0.5103893708431477 24.22277564269515 -13.999999999999998 0.20303099014765258 3.2284218917642917 0.4515204538210576 0.9994873102249403 0.004805801885380021 12.592472695429615 0.14286062765447244 11.158057626848281 0.05814645049694626 1.0000000000000041e-14 13.999999999999998 -2.776901437943234 THSDQFLVAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 THSDQFLVAFK 11 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 16885700.0 0.0 5189700.0 11696000.0 False True 0.0 7261974.273927978 8632466.727521108 0.0 THSDQFLVAFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 THSDQFLVAFK 11 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 49501000.0 15585000.0 33916000.0 0.0 False True 23643584.4161187 27863424.81308253 0.0 1.0 1.1784771852988167 0.0 24.494945431848613 -6.924158386340472 1.2511936411214066 1.094537794197722 1.3637307663537228e-18 0.9612939641993294 0.1020317228826423 0.12000936044000846 0.37566057676140824 0.06717646812530924 0.13065657858579977 1.1908076436286919e-07 6.924158386340472 -1.094537794197722 down THSDQFLVAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THSDQFLVAFK 11 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 43962000.0 14934000.0 11216000.0 17812000.0 False True 20455503.376175206 10720440.033647902 13605172.449655041 1.0 0.5240858578007003 0.6651106159284823 24.285985704218042 -10.687409197278258 10.120968846798924 1.0002780762236756 0.5945982368645978 0.916794378269598 0.05757311641874679 0.0003614825298035404 1.116461064257253e-05 0.055780823872744134 0.0185816434232556 2.053954424397735e-11 10.687409197278258 -0.4056798393590778 THSDQFLVAFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THSDQFLVAFK 11 0 P36542-2;P36542 P36542-2 ATP5C1 ATP synthase subunit gamma, mitochondrial 0 41353000.0 15585000.0 15516000.0 10252000.0 False True 20175089.726278406 14652520.960339814 8386241.194403168 1.0 0.7262679452302336 0.4156730556434623 24.266071753941063 -6.969480955136285 0.2702966929392964 1.0769345007445281 0.055665394905984565 0.9999780456168267 0.0011184665525528297 0.07647149169264185 0.009631283777890479 0.006077322664634334 0.02887525878957912 1.0728006917097748e-07 6.969480955136285 -1.0212691058385435 down THSDSKPYGPMSVGLDFSLPGMEHVYGIPEHADNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 THSDSKPYGPMSVGLDFSLPGMEHVYGIPEHADNLR 36 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 35875600.0 14747200.0 3710700.0 17417700.0 False True 14279058.208209168 5192401.861044869 12855481.850200439 1.0 0.363637558257148 0.9003032036671507 23.76739749209724 -10.281133694186412 8.054354812442533 1.000000596868257 0.6319703809621772 0.38538774829490086 0.21909283228931928 2.348102857535723e-06 2.0997053623764534e-07 0.21213606721315112 0.07071190756082904 5.234392750615803e-11 10.281133694186412 -0.36803021590607987 THSDSKPYGPMSVGLDFSLPGMEHVYGIPEHADNLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 THSDSKPYGPMSVGLDFSLPGMEHVYGIPEHADNLR 36 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 138135000.0 39921000.0 50545000.0 47669000.0 False True 60563075.61603303 41524849.84011246 38247201.255935065 1.0 0.6856463186146291 0.6315267325328797 25.851935136763196 -13.999999999999998 0.24750644151320628 3.159006862085704 0.6092440556149114 0.9995380641854591 0.003491554307787764 13.900431817147059 0.15743034434695127 14.898746110171421 0.025326828842830214 1.0000000000000041e-14 13.999999999999998 -2.5497628064707927 THSDSKPYGPMSVGLDFSLPGMEHVYGIPEHADNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THSDSKPYGPMSVGLDFSLPGMEHVYGIPEHADNLR 36 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 31289000.0 14747200.0 11003300.0 5538500.0 False True 12262950.211732246 10944023.038915962 6696574.742869355 1.0 0.892446177302878 0.546081866699792 23.547802767531515 -6.949846979590404 0.5605204766165116 1.004517696097743 0.417442231935292 0.9991892235523148 0.005514624745506291 0.08354723742616031 0.03621702531810718 0.005907653821455364 0.02879553014494759 1.1224138587597823e-07 6.949846979590404 -0.5870754641624512 THSDSKPYGPMSVGLDFSLPGMEHVYGIPEHADNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 THSDSKPYGPMSVGLDFSLPGMEHVYGIPEHADNLR 36 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 177086000.0 56573000.0 93987500.0 26525500.0 False True 73234863.72054861 88757013.00334753 21698131.174613826 1.0 1.2119502719637565 0.29628144400473094 26.12602727641809 -6.845765190777177 1.2552422187150214 1.112825538882464 0.26253981455405584 0.9339232883284907 0.10060529816188177 0.16218299898423594 0.4938659159304157 0.06277574743500738 0.1449367220752394 1.426378582722653e-07 6.845765190777177 -0.8502857243284081 down THSQGGYGSQGYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 THSQGGYGSQGYK 13 0 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 15855400.0 1256900.0 8140500.0 6458000.0 False True 1647808.0718369132 6925969.131420474 5789788.1095102625 1.0 4.203140675054267 3.5136301420444123 20.652116783972705 -10.630332426228312 9.084051671719962 0.9987467501076489 3.8583854085493066 0.958183268528644 0.2814914963581003 0.00714298797607361 0.0002906761767199378 0.27248491909433153 0.09085098979116071 2.3424351361349436e-11 10.630332426228312 2.8596386584416575 THSQGGYGSQGYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 THSQGGYGSQGYK 13 0 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 11991900.0 1830600.0 5131400.0 5029900.0 False True 1772488.605019777 7180394.779897489 3712418.2962344745 1.0 4.0510245084579095 2.094466664395313 20.75734492201644 -9.868529188882242 6.421640191716956 0.9999998880880899 3.072745586426848 0.5994218707388994 0.7987613950330645 1.2845858213112392e-06 2.2971368527413047e-07 0.7733974412346188 0.2577991317129136 1.3535391164057698e-10 9.868529188882242 2.0727456983387578 THSQGGYGSQGYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 THSQGGYGSQGYK 13 0 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 7609100.0 1821860.0 3806400.0 1980840.0 False True 2763894.8158068676 3127118.180461061 1589326.105766984 1.0 1.1314172169566292 0.5750313277761295 21.398271282155523 -6.844433223331891 1.261705305731637 1.069922220343915 0.5550723636604536 0.9318000795695094 0.062009825372622736 0.16368653115725693 0.5042473405142806 0.03850769308383388 0.08884567944679014 1.4307599560716874e-07 6.844433223331891 -0.5148498566834613 THSQGGYGSQGYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THSQGGYGSQGYK 13 0 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 13210300.0 1256900.0 5909800.0 6043600.0 False True 1721609.8964453333 5648685.4949048115 4616226.151849045 1.0 3.28104845735834 2.6813427138054475 20.715326845495596 -10.457960408396296 10.306091471373152 0.9999948645072132 2.9811955855818937 0.9356988039571995 0.24482884458682813 2.8891661970328157e-05 1.5197504388773665e-06 0.23705512054511335 0.07901816981299907 3.4836907197088264e-11 10.457960408396296 1.9812007210746805 THSQGGYGSQGYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THSQGGYGSQGYK 13 0 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 5300690.0 1830600.0 1585600.0 1884490.0 False True 1522225.0093303819 1577058.0580830404 2278528.1461027116 1.0 1.0360216449056892 1.4968405670230205 20.537750197450716 -6.922489182557382 0.806030283626307 0.9907162535020807 1.5755852041575393 0.9948454968246924 0.016240072818242166 0.09672847870981545 0.09817951495517448 0.014180359733615793 0.043543980544549554 1.1953933002573869e-07 6.922489182557382 0.5848689506554586 THSQGGYGSQGYK(ub)YNWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 THSQGGYGSQGYKYNWK 17 1 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 1 69217500.0 4385400.0 7745100.0 57087000.0 True False 6652972.415684766 6362926.3922574995 45803729.42787907 1.0 0.9564035433630438 6.8847015388030375 22.66556762140627 -6.905241077721401 0.9275181426806091 0.7876966076719872 7.577732790071514 0.9889987786595934 0.2920473420668272 0.10765022398209813 0.15645332688250288 0.23361399275690425 0.6254883869583686 1.2438239709675138e-07 6.905241077721401 6.790036182399527 up THSQGGYGSQGYK(ub)YNWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THSQGGYGSQGYKYNWK 17 1 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 1 45560600.0 4385400.0 8159200.0 33016000.0 True False 5676986.749157615 7705133.34748677 27007426.77276777 1.0 1.3572575889189988 4.757352441728932 22.43669394349872 -6.927016326177609 0.7708902769531741 0.9421725728240085 5.40513942779127 0.9959186116278678 0.10817897078691938 0.0942170531532881 0.08548917126078917 0.09686009869627205 0.31284931064030325 1.1829970831741026e-07 6.927016326177609 4.462966854967261 up THSTHPDDEDSGPYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THSTHPDDEDSGPYK 15 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 0 1741330.0 633890.0 501480.0 605960.0 False True 820583.100839951 473572.19716365193 495681.49767465296 1.0 0.5771166828550359 0.6040600850386415 19.646289917985513 -10.708657684599508 6.757775152901172 1.0043988008286688 0.5905883839468465 0.996762293104431 0.010999597880737292 0.0007333765445485742 3.161740720902059e-05 0.01071452092157913 0.0035501049505894896 1.955880493590119e-11 10.708657684599508 -0.4138104168818223 THSTHPDDEDSGPYK(ub)HISPGDTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 THSTHPDDEDSGPYKHISPGDTK 23 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 38919400.0 1350000.0 1810400.0 35759000.0 True False 2048048.6982200982 1487319.9752802372 28691217.97627353 1.0 0.7262131884719467 14.00905066427779 20.965818589274075 -6.902196666067064 0.9472970044573917 0.48053933956016753 15.467109459644366 0.9876272766906896 0.6894278186126619 0.1098057037710271 0.16844959308099028 0.5435153885308558 1.4303411841034603 1.2525738305156647e-07 6.902196666067064 14.986570120084199 up THSVNGITEEADPTIYSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 THSVNGITEEADPTIYSGK 19 0 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 0 8063300.0 2803200.0 1527000.0 3733100.0 False True 2714213.950394101 2136739.063199803 2755289.119400568 1.0 0.7872404689724443 1.0151333571181824 21.3721030163178 -11.1215720177724 11.592044259522737 3.535611295361509 0.9011869130453132 0.2004299589361792 0.09303688199436995 0.0372551574145365 0.00039071571171015384 0.0005504639859141284 0.03002752454560497 7.558367117745593e-12 11.1215720177724 -2.6344243823161957 THTGEKPYECK(ub)ECGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 THTGEKPYECKECGK 15 2 P58317;Q8N8Z8;F8W7T7;A0A494BZV4;A0A3F2YPB8;A0A494C069;K7EQV7;A0A0A0MTT2;K7ER43;A0A087WVH9;Q9H0M5;Q9H7R0;Q8N7K0;Q08AG5;Q86YE8-3;P15621;Q8N8Z8-2;Q32M78;Q8N972;Q8N7K0-2;M0QY24;Q86UE3;S4R3U0;Q9BR84;Q08ER8;P17030-2;Q3KP31-2;Q96BR6-2;P17030;Q96BR6;C9JN71;Q147U1;Q15935;Q86YE8;Q8IYI8;Q14584;Q8TBZ8;Q9BUY5;Q9H7R0-2;Q3KP31;Q86YE8-2;Q86YE8-4;Q8NHY6;C9JVC3;A0A494C0W3;Q9BY31;Q8N8L2 P58317;C9JVC3;Q8N8L2 ZNF121;ZNF441;ZNF44;ZNF700;ZNF559;ZNF426;ZNF442;ZNF433;ZNF844;ZNF573;ZNF699;ZNF709;ZNF546;ZNF543;ZNF25;ZNF791;ZNF669;ZNF878;ZNF846;ZNF77;ZNF440;ZNF266;ZNF564;ZFP28;ZNF717;ZNF491 Zinc finger protein 121;Zinc finger protein 441;Zinc finger protein 700;Zinc finger protein 442;Zinc finger protein 433;Zinc finger protein 844;Zinc finger protein 573;Zinc finger protein 44;Zinc finger protein 699;Zinc finger protein 709;Zinc finger protein 546;Zinc finger protein 559;Zinc finger protein 543;Zinc finger protein 25;Zinc finger protein 791;Zinc finger protein 669;Zinc finger protein 878;Zinc finger protein 846;Zinc finger protein 77;Zinc finger protein 440;Zinc finger protein 266;Zinc finger protein 564;Zinc finger protein 426;Zinc finger protein 28 homolog;Zinc finger protein 717;Zinc finger protein 491 1 7557390.0 562710.0 830480.0 6164200.0 True False 853672.2096114324 682274.3554301434 4945843.168135164 1.0 0.7992228723724011 5.79360920087392 19.703322689074085 -6.897531656760738 0.97672227353568 0.7780560203676574 6.292382266467913 0.9852983114878735 0.2799078317287516 0.11324571480355078 0.1878355187828483 0.21589046679566196 0.5550776495603281 1.266100975027089e-07 6.897531656760738 5.514326246100256 up THTGEKPYECK(ub)ECGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THTGEKPYECKECGK 15 2 P58317;Q8N8Z8;F8W7T7;A0A494BZV4;A0A3F2YPB8;A0A494C069;K7EQV7;A0A0A0MTT2;K7ER43;A0A087WVH9;Q9H0M5;Q9H7R0;Q8N7K0;Q08AG5;Q86YE8-3;P15621;Q8N8Z8-2;Q32M78;Q8N972;Q8N7K0-2;M0QY24;Q86UE3;S4R3U0;Q9BR84;Q08ER8;P17030-2;Q3KP31-2;Q96BR6-2;P17030;Q96BR6;C9JN71;Q147U1;Q15935;Q86YE8;Q8IYI8;Q14584;Q8TBZ8;Q9BUY5;Q9H7R0-2;Q3KP31;Q86YE8-2;Q86YE8-4;Q8NHY6;C9JVC3;A0A494C0W3;Q9BY31;Q8N8L2 P58317;C9JVC3;Q8N8L2 ZNF121;ZNF441;ZNF44;ZNF700;ZNF559;ZNF426;ZNF442;ZNF433;ZNF844;ZNF573;ZNF699;ZNF709;ZNF546;ZNF543;ZNF25;ZNF791;ZNF669;ZNF878;ZNF846;ZNF77;ZNF440;ZNF266;ZNF564;ZFP28;ZNF717;ZNF491 Zinc finger protein 121;Zinc finger protein 441;Zinc finger protein 700;Zinc finger protein 442;Zinc finger protein 433;Zinc finger protein 844;Zinc finger protein 573;Zinc finger protein 44;Zinc finger protein 699;Zinc finger protein 709;Zinc finger protein 546;Zinc finger protein 559;Zinc finger protein 543;Zinc finger protein 25;Zinc finger protein 791;Zinc finger protein 669;Zinc finger protein 878;Zinc finger protein 846;Zinc finger protein 77;Zinc finger protein 440;Zinc finger protein 266;Zinc finger protein 564;Zinc finger protein 426;Zinc finger protein 28 homolog;Zinc finger protein 717;Zinc finger protein 491 1 6528500.0 1536700.0 1770300.0 3221500.0 True False 2104859.517756021 1692082.2924007545 2460648.0488751237 1.0 0.8038932185862332 1.1690319606214892 21.005292517675247 -6.7608229745893365 1.6093958815268274 0.8862070482648444 1.1704195326566764 0.694315716556937 0.08249287662743739 0.2815339355791072 1.4374027868320343 0.040438836584866945 0.09710117456153175 1.7345108681848437e-07 6.7608229745893365 0.284212484391832 THTMGGDLSGK(ub)AQNASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THTMGGDLSGKAQNASK 17 1 Q99661;Q99661-2;Q5JR91 Q99661 KIF2C Kinesin-like protein KIF2C;Kinesin-like protein 1 3238800.0 1311200.0 989580.0 938020.0 True False 1795986.073847657 945857.0834965481 716478.995128309 1.0 0.5266505666551062 0.3989334915016071 20.776344732727946 -13.999999999999998 0.18385390417671796 3.485906248954651 0.30141790749647074 0.9994939933179816 0.005816067558442518 12.257024106016601 0.13595504196632946 10.895209862017497 0.09232430448587613 1.0000000000000041e-14 13.999999999999998 -3.1844883414581804 THTMGGDLSGK(ub)AQNASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THTMGGDLSGKAQNASK 17 1 Q99661;Q99661-2;Q5JR91 Q99661 KIF2C Kinesin-like protein KIF2C;Kinesin-like protein 1 5772840.0 1635200.0 3508900.0 628740.0 True False 1359741.2516426533 3489996.859237879 760206.6270346995 1.0 2.5666624845144197 0.5590818298086654 20.374900713088525 -6.698466007684522 1.8360972938500961 1.9742848336971233 0.5651773556275106 0.4103836840718057 0.6614947082908713 0.39873701284477214 2.6122626256164496 0.28751933514463723 0.7408939511691307 2.0023223376234817e-07 6.698466007684522 -1.4091074780696127 THTQDAVPLTLGQEFSGYVQQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 THTQDAVPLTLGQEFSGYVQQVK 23 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 26779500.0 3994800.0 14211000.0 8573700.0 False True 5237221.485698225 12090774.194044122 7686575.76873771 1.0 2.308623805019807 1.4676820122517575 22.320370187967015 -10.154036077605662 5.183955319180038 0.9999634364463434 1.888152908636491 0.5979486408848321 0.3433130492796441 0.0001450839595582084 2.3676593138513235e-05 0.3324250521986886 0.11080381019929009 7.013970297161582e-11 10.154036077605662 0.8881894721901475 THTQDAVPLTLGQEFSGYVQQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 THTQDAVPLTLGQEFSGYVQQVK 23 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 64566000.0 21642000.0 11808000.0 31116000.0 False True 20954986.55623189 16522995.977906529 22965786.140009124 1.0 0.7884994788027047 1.0959580469489365 24.32079026011272 -6.7215832437853145 1.7534867142319186 0.8715443893225405 1.0955261094342124 0.5200254911217533 0.08898338519275446 0.3522569174163836 2.1175231577776166 0.04027906979130154 0.10093274726040732 1.8985269053718807e-07 6.7215832437853145 0.22398172011167183 THTQDAVPLTLGQEFSGYVQQVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 THTQDAVPLTLGQEFSGYVQQVK 23 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 88054000.0 12596000.0 61308000.0 14150000.0 False True 19109052.890948452 50367108.398409665 11353246.29783467 1.0 2.63577209639037 0.5941291995278561 24.187752939471295 -6.693350527430141 1.85436451227753 2.022269037668594 0.6008542789232378 0.386244100852394 0.6913500862014831 0.40949230543610793 2.7325661320032557 0.29795908396384657 0.7726869122366743 2.0260467980758557e-07 6.693350527430141 -1.4214147587453563 THTQDAVPLTLGQEFSGYVQQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THTQDAVPLTLGQEFSGYVQQVK 23 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 42919800.0 3994800.0 18357000.0 20568000.0 False True 5471785.515410785 17545927.04151878 15710262.011256725 1.0 3.2066182038938256 2.871139953678777 22.383580249489906 -10.182337231806414 5.207982391790406 0.9998875347972911 3.0388790787873288 0.9800989052443653 0.13695842214168896 0.00017885563714915509 2.8079673144885932e-05 0.13261648660819728 0.04420314067261745 6.571473610215863e-11 10.182337231806414 2.0389915439900377 THTQDAVPLTLGQEFSGYVQQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THTQDAVPLTLGQEFSGYVQQVK 23 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 38877000.0 21642000.0 9712500.0 7522500.0 False True 17996281.903161913 9660176.83471969 9095419.969889821 1.0 0.5367873701190696 0.5054055064725216 24.101195535546996 -13.999999999999998 0.38241802124331403 7.978757387741661 0.5027643398587553 0.9998113875650594 0.003105449122291102 24.343386686837455 0.20191159652067825 140.00087820808687 0.008444484247060357 1.0000000000000041e-14 13.999999999999998 -7.4759930478829055 THTQDAVPLTLGQEFSGYVQQVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THTQDAVPLTLGQEFSGYVQQVK 23 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 41145000.0 12596000.0 12538000.0 16011000.0 False True 16305770.304279963 11840249.278212214 13097162.286733227 1.0 0.7261386035288604 0.8032225428378238 23.958879261563744 -9.985964321864603 6.575624325978846 1.0000000505522055 0.7646805731833399 0.9255168800794771 0.031469386445112865 2.3324995589263636e-08 3.5560220731992147e-09 0.03047010898787978 0.010156700801439397 1.0328462526023552e-10 9.985964321864603 -0.2353194773688656 THTQGQAFSLSVFHHWQIVPGDPLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 THTQGQAFSLSVFHHWQIVPGDPLDK 26 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 28898900.0 16571000.0 5579200.0 6748700.0 False True 16044962.675506799 7807003.655143632 4981013.013339752 1.0 0.48657038430268823 0.31044092243003124 23.935617097774923 -13.999999999996396 0.14930173243348865 3.480015391395532 0.11509922380930801 0.9995685873003244 0.006075823337327371 11.955177364312583 0.1216545436190631 8.603283431097823 0.17595247657512753 1.000000000008299e-14 13.999999999996396 -3.364916167586224 THTQGQAFSLSVFHHWQIVPGDPLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THTQGQAFSLSVFHHWQIVPGDPLDK 26 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 158808000.0 36880000.0 74029000.0 47899000.0 False True 47741887.01348399 69909221.07327904 39181873.48524357 1.0 1.4643162523830322 0.8207022373074031 25.508752254745033 -6.713135280051896 1.7838784677116029 1.2845332579848296 0.8220620638406456 0.4800107024978414 0.19556771365857548 0.368828215516942 2.28976102340554 0.08717741046820233 0.22064611469362472 1.935818874385083e-07 6.713135280051896 -0.46247119414418403 THTYYQVLIDAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 THTYYQVLIDAR 12 0 Q9Y2S7;B4DEM9 Q9Y2S7 POLDIP2 Polymerase delta-interacting protein 2 0 7084000.0 2320800.0 2053400.0 2709800.0 False True 3042591.2746591712 1747040.7240905107 2429415.890237058 1.0 0.5741950089192355 0.7984693542214931 21.536869112303595 -10.18285475522035 4.986339348372625 1.000023009284713 0.6863321815738913 0.7228436174002537 0.09155961808737192 2.689215702510386e-05 4.407024695598763e-06 0.08865967752587824 0.02955073966636709 6.563647432169452e-11 10.18285475522035 -0.3136908277108218 THTYYQVLIDAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 THTYYQVLIDAR 12 0 Q9Y2S7;B4DEM9 Q9Y2S7 POLDIP2 Polymerase delta-interacting protein 2 0 7357700.0 2569900.0 1345400.0 3442400.0 False True 2488319.9311921364 1882625.236168313 2540732.170213636 1.0 0.7565848798495781 1.0210633039443562 21.246740558599253 -11.798787781852681 12.734275255791658 0.9134219645267005 0.8999416829563229 0.0 0.12279153998706671 0.0 0.0 0.0 0.03575404611113445 1.5893231821973477e-12 11.798787781852681 -0.013480281570377617 THVADFAPEVAWVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 THVADFAPEVAWVTR 15 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 26103300.0 5570800.0 9316500.0 11216000.0 False True 7303372.747703946 7926514.515432562 10055475.911469052 1.0 1.0853224652848947 1.3768263320026106 22.800131433682996 -6.94849836644568 0.5751018219168819 0.996447767200029 1.4799982474178501 0.9990780438450241 0.004898642050233072 0.08409456724016429 0.038502848676658576 0.005160114282152607 0.024319236368020462 1.1259047038624807e-07 6.94849836644568 0.4835504802178211 THVADFAPEVAWVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 THVADFAPEVAWVTR 15 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 21935500.0 7682700.0 4160800.0 10092000.0 False True 7438816.893797361 5822229.138285354 7448602.446489665 1.0 0.7826821417179993 1.0013154716444845 22.826641755552906 -10.97676651383947 9.331603195375669 1.065557574988683 0.8919988066812455 0.2454875682888693 0.08925668318090932 0.06607270064647752 0.00016450528906535746 0.046905853449541554 0.028807470624781114 1.054953910128277e-11 10.97676651383947 -0.17355876830743744 THVADFAPEVAWVTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 THVADFAPEVAWVTR 15 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 32270800.0 6605700.0 19965000.0 5700100.0 False True 10021329.841357412 16402089.762743022 4573472.736557417 1.0 1.6367178829951896 0.4563738355046429 23.25657063264772 -6.760205805588149 1.6118947406464776 1.3697444547570274 0.452045329964585 0.6917591259172939 0.2678106664446434 0.2825572069513192 1.447002826651932 0.13109374868969625 0.3149498703311698 1.7369775063087844e-07 6.760205805588149 -0.9176991247924424 THVADFAPEVAWVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THVADFAPEVAWVTR 15 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 21493400.0 5570800.0 7884400.0 8038200.0 False True 7630475.305209386 7536041.137775813 6139742.711925512 1.0 0.9876240779694153 0.804634372872403 22.863341495205887 -6.920602022856821 0.8202548516193031 1.0039506058418213 0.7747136487683876 0.9943463978127733 0.006716174181477208 0.0978188555519241 0.10379003701264371 0.005805187619496058 0.017490498506557713 1.200598999598258e-07 6.920602022856821 -0.22923695707343372 THVADFAPEVAWVTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THVADFAPEVAWVTR 15 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 17177100.0 7682700.0 4384100.0 5110300.0 False True 6388505.4513178915 4360481.983124287 6178840.102642461 1.0 0.6825511876529367 0.9671808453051912 22.607047030987182 -10.303056826182827 7.741503511826329 1.0000007046645019 0.8248660169812169 0.33545983125851153 0.11619957115184752 1.413245131124356e-06 1.2734027408210557e-07 0.11251020362259927 0.03750325032562912 4.976719617748031e-11 10.303056826182827 -0.175134687683285 THVDSHGHNVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 THVDSHGHNVFK 12 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 10330500.0 1269700.0 5141800.0 3919000.0 False True 1664588.9957922907 4374663.482579425 3513499.4737025006 1.0 2.6280742535470303 2.1107309267235594 20.66673457429073 -9.77865396167109 6.713376964633197 0.9999999916352204 2.369402590135473 0.9033075997910502 0.21120452875921025 2.7111226826484672e-08 4.992989462506976e-09 0.20449791020259817 0.06816596854390579 1.6647385569487716e-10 9.77865396167109 1.3694025985002525 THVDSHGHNVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 THVDSHGHNVFK 12 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 7370300.0 2091800.0 1990000.0 3288500.0 False True 2025396.9539934308 2784617.377712903 2427143.197114667 1.0 1.3748501854031794 1.1983543237433638 20.949773256301434 -10.38808669809468 5.657377685897548 0.9999010410810301 1.2866022545732727 0.778557169798977 0.0720541337965698 8.996634302134757e-05 9.730877966639208e-06 0.06979008666385161 0.02325537168495912 4.0917896728514444e-11 10.38808669809468 0.28670121349224265 THVDSHGHNVFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 THVDSHGHNVFK 12 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 10752400.0 2021500.0 6248000.0 2482900.0 False True 3066763.2914458746 5132995.584153187 1992153.7267062727 1.0 1.673750171221449 0.6495948781775851 21.548285385607578 -6.729277480040574 1.7258334863084561 1.405801771957266 0.6502912826207254 0.5558224472546194 0.283247561149197 0.3376488371844181 1.9698976538984323 0.13007615267470116 0.323043358222416 1.8651876017664476e-07 6.729277480040574 -0.7555104893365405 THVDSHGHNVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THVDSHGHNVFK 12 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 9987100.0 1269700.0 4468500.0 4248900.0 False True 1739142.4023523282 4271066.894646543 3245397.328842318 1.0 2.4558465648756456 1.8660906228567946 20.72994463581362 -10.19837747932595 6.23539033427846 0.9999883484803425 2.1609685938662224 0.8378455290376406 0.24076685512011026 3.899949775973171e-05 5.0135086740895876e-06 0.23312383977094236 0.07770716834990872 6.333190048443158e-11 10.19837747932595 1.16098024538588 THVDSHGHNVFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THVDSHGHNVFK 12 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 6291100.0 2091800.0 2874800.0 1324500.0 False True 1739424.3824523638 2859312.881796875 1601446.82620393 1.0 1.6438270675300142 0.9206763124396915 20.73017853173571 -6.671923603851441 1.9312689274693324 1.4102830465728509 0.9236177764568733 0.28736028526165314 0.27336494764471503 0.45667034432390585 3.285806910032121 0.11389839012036362 0.3034675810252916 2.1285134369411055e-07 6.671923603851441 -0.4866652701159776 THVDSHGHNVFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THVDSHGHNVFK 12 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 6461600.0 2021500.0 1644300.0 2795800.0 False True 2616871.5997222844 1552793.259544134 2286993.08733051 1.0 0.5933777032502948 0.8739416513875642 21.319411707700027 -10.086666909340508 5.507169690222695 1.0000024863176196 0.73365967731883 0.5457785648796336 0.11453975219318269 3.496611261810029e-06 5.800607632107542e-07 0.11090367258879834 0.0369675460601926 8.19092766524832e-11 10.086666909340508 -0.2663428089987896 THYDPPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 THYDPPR 7 0 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;E7EN40;H0YBD7 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 10949200.0 3336000.0 4415000.0 3198200.0 False True 4373528.305869957 3756299.2095352113 2867280.9433006677 1.0 0.8588715899000063 0.6555990364695546 22.060366200437624 -6.965923026570667 0.34184177412378486 1.021582699538195 0.4861137295080936 0.9999309245746623 0.0011748685507525119 0.07764913606946214 0.013763296383448429 0.0028536076813673937 0.01757060555076005 1.081625639335716e-07 6.965923026570667 -0.5354689700301013 THYDPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 THYDPPR 7 0 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;E7EN40;H0YBD7 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 7302600.0 2974700.0 2440000.0 1887900.0 False True 2880269.776768459 3414304.7244319045 1393402.3542140143 1.0 1.1854114333215724 0.48377494547658406 21.457772515498085 -6.836450735018919 1.2988212021822207 1.0987227542009035 0.4622786259766023 0.9181694873040668 0.08492130056564842 0.17298613144743624 0.56839054803314 0.051297809472649766 0.11808867365003795 1.457301006933524e-07 6.836450735018919 -0.6364441282243012 down THYDPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 THYDPPR 7 0 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;E7EN40;H0YBD7 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 9028700.0 3336000.0 3106100.0 2586600.0 False True 4569409.352010216 2968862.231500866 1975698.3526991778 1.0 0.649725599698083 0.432374996525538 22.123576261960515 -8.865495715128764 0.13694293991470818 1.509783428656665 1.8776696459743073e-14 0.9998999386833609 0.002339112708375746 0.36918709934047333 0.041267364193459354 0.24820917875308848 0.1731485881685149 1.363026454142993e-09 8.865495715128764 -1.509783428656646 THYDPPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THYDPPR 7 0 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;E7EN40;H0YBD7 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 5269940.0 2974700.0 1339200.0 956040.0 False True 2473594.8515541875 1331985.4637896144 1155943.5437704837 1.0 0.5384816607912621 0.46731320735252635 21.23817779093236 -13.999999999999998 0.2631803062455299 4.435299629965407 0.4420832003769068 0.9995688892600888 0.004902826955074544 14.560054884276093 0.16235372345795937 26.652237175276124 0.030601236441645124 1.0000000000000041e-14 13.999999999999998 -3.9932164295884998 THYPAQQGEYQTHQPVYHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 THYPAQQGEYQTHQPVYHK 19 0 O95817;C9JFK9 O95817 BAG3 BAG family molecular chaperone regulator 3 0 18742800.0 2511900.0 11437000.0 4793900.0 False True 3810735.9444882 9395977.992311142 3846383.563758988 1.0 2.465659685998807 1.0093545235854897 21.8616382129569 -6.644679419133443 2.027391026221366 1.9550255087157486 1.015432259736388 0.17284596999258728 0.6263810438097677 0.5216734114140751 4.103606921800406 0.25109381730586217 0.6937431708140162 2.2663166052739593e-07 6.644679419133443 -0.9395932489793606 THYPAQQGEYQTHQPVYHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 THYPAQQGEYQTHQPVYHK 19 0 O95817;C9JFK9 O95817 BAG3 BAG family molecular chaperone regulator 3 0 2357450.0 684430.0 1314300.0 358720.0 False True 569133.870390033 1307219.6050318768 433726.69346611865 1.0 2.29685786252016 0.7620820267978103 19.118408514370692 -6.682718976324017 1.892108577695121 1.8185214549370674 0.7677789481500061 0.3366555943880174 0.5493147399204996 0.43251641564215754 2.9960201139727536 0.2327497441187263 0.6117584007730759 2.076256588908529e-07 6.682718976324017 -1.0507425067870613 THYPAQQGEYQTHQPVYHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THYPAQQGEYQTHQPVYHK 19 0 O95817;C9JFK9 O95817 BAG3 BAG family molecular chaperone regulator 3 0 14000100.0 2511900.0 5337500.0 6150700.0 False True 3251704.0669514765 5040463.432960418 5031335.711511468 1.0 1.5500990647300605 1.5472920068733143 21.63276453504935 -10.09016212278332 4.860686552503553 0.9999793141004749 1.5486955358054146 0.9999803707526225 0.0011459765872538716 796921.740355764 0.00820662494790763 185.02191791637048 0.0003922982645854733 8.1252714193838e-11 10.09016212278332 0.5487162217049397 THYSNIEANESEEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 THYSNIEANESEEVR 15 0 K7ELJ7;A0A0C4DGQ5;P04632;U3KQE2;K7EM73;A0A075B7C0;K7EIV0 K7ELJ7 CAPNS1 Calpain small subunit 1 0 6284200.0 2378400.0 1852300.0 2053500.0 False True 3078885.685273057 1749217.876697439 1679784.0706893175 1.0 0.568133427318951 0.5455818248543849 21.553976872448615 TIADLELHYQEFIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIADLELHYQEFIR 14 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 27931300.0 4881700.0 15403000.0 7646600.0 False True 7405895.800074862 12654214.305811713 6135246.1583761675 1.0 1.7086676139412869 0.8284272860433912 22.820242820457697 -6.692433392934992 1.857695963198658 1.4432837006649903 0.8313761188646002 0.3817752027786103 0.2995723177186118 0.4115134354356519 2.755251123876444 0.12891321212790005 0.33468198437220187 2.0303298844991878e-07 6.692433392934992 -0.6119075818003902 TIAECLADELINAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIAECLADELINAAK 15 0 M0R0F0;P46782;M0R0R2;M0QZN2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 0 101227000.0 13893000.0 74872000.0 12462000.0 False True 21076696.71434952 61510506.622393884 9998880.237711357 1.0 2.9184130443228353 0.4744045223606544 24.329145439760733 -6.69733081920281 1.84003395036419 2.1943384800163974 0.48194528651269125 0.4050581905903645 0.8101862351320517 0.4011139115237566 2.6382754456392736 0.35149394418241814 0.9070591415541212 2.0075629902626197e-07 6.69733081920281 -1.7123931935037062 TIAECLADELINAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIAECLADELINAAK 15 0 M0R0F0;P46782;M0R0R2;M0QZN2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 0 33728700.0 13893000.0 9520700.0 10315000.0 False True 17984762.371972155 8990864.675632082 8437775.840837747 1.0 0.49991567804329967 0.46916248690543505 24.100271761853183 -13.999999999999998 0.39669534271244017 9.25287487862924 0.4672155790956991 0.9998330426162436 0.003143912843351029 26.288223513889502 0.20719490776584895 186.50966358208012 0.007941573269985713 1.0000000000000041e-14 13.999999999999998 -8.785659299533542 TIAECLADELINAAK(ub)GSSNSYAIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIAECLADELINAAKGSSNSYAIK 24 1 M0R0F0;P46782;M0R0R2;M0QZN2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 1 308505000.0 21244000.0 39634000.0 247627000.0 True False 32228701.14443542 32561003.03814459 198683414.91123027 1.0 1.0103107442096388 6.16479745866317 24.94184271142871 -6.907334543756999 0.9136770643283875 0.8266435118186722 6.794341365902599 0.9898766638213449 0.2447235700616356 0.10620761770352609 0.14851659205534315 0.19775454216349508 0.5363298624398408 1.2378426898061516e-07 6.907334543756999 5.9676978540839265 up TIAECLADELINAAK(ub)GSSNSYAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIAECLADELINAAKGSSNSYAIK 24 1 M0R0F0;P46782;M0R0R2;M0QZN2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 1 318984000.0 21244000.0 28022000.0 269718000.0 True False 27500776.781845286 26462551.066682294 220632091.54038572 1.0 0.9622474040133885 8.022758531171258 24.71296903352116 -6.905695909624719 0.9245489856101575 0.7505370784447812 8.855947669224758 0.9891934046272338 0.3450772821917727 0.10733342249919847 0.15471581124923414 0.27663990234411134 0.7426884292878163 1.242522009489348e-07 6.905695909624719 8.105410590779977 up TIAEIFGNPNYLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIAEIFGNPNYLR 13 0 Q16401;Q16401-2 Q16401 PSMD5 26S proteasome non-ATPase regulatory subunit 5 0 5827400.0 1064200.0 2324100.0 2439100.0 False True 1395176.505727458 1977353.3392708458 2186725.3294992996 1.0 1.4172782663365129 1.5673467267563546 20.412016220288553 -11.856464800191603 0.17420486324360465 2.781824619627132e-20 1.7103237168761527 0.9994883930896229 0.0054291411551914736 4.977386755256525 0.1118645191755014 1.9397949283830735 0.11611533613411038 1.3916665856216087e-12 11.856464800191603 1.7103237168761527 TIAEIFGNPNYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIAEIFGNPNYLR 13 0 Q16401;Q16401-2 Q16401 PSMD5 26S proteasome non-ATPase regulatory subunit 5 0 6112600.0 1064200.0 2583800.0 2464600.0 False True 1457663.4989236398 2469639.1725159977 1882512.2400303083 1.0 1.6942450533608173 1.2914587224145924 20.475226281811445 -10.142506012735618 4.422674779494528 0.9999234628970108 1.4928518879097104 0.6662531688619562 0.16443683110714205 114943960.97188672 14.589936945228073 93042.91382475631 0.05629110103987878 7.202677791804621e-11 10.142506012735618 0.4929284250126995 TIAFLLPMFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIAFLLPMFR 10 0 A0A0C4DG89;Q7L014;D6RJA6 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 5862960.0 1764120.0 2705700.0 1393140.0 False True 2312778.403762383 2302020.1067359946 1248991.2367425102 1.0 0.9953483234671826 0.5400393028189279 21.14119561173224 -6.909134498858941 0.9016096995304959 1.0144860497678923 0.4822749142722851 0.9905908095016567 0.020926942520162025 0.10499310704384682 0.1418927633385863 0.017060185007254213 0.04681609444020104 1.232723005872274e-07 6.909134498858941 -0.5322111354956072 TIAFLLPMFR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TIAFLLPMFR 10 0 A0A0C4DG89;Q7L014;D6RJA6 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 82823920.0 27594120.0 3651400.0 51578400.0 False True 37796411.867053956 3490069.074434907 39396644.210492246 1.0 0.09233863486065723 1.0423382078983314 25.171745945554335 -12.007578833300553 18.32633803311494 0.9237180416168601 0.6106045792415452 0.0 0.44967481173466656 0.0 0.0 0.0 0.1300364966029715 9.827004766426506e-13 12.007578833300553 -0.3131134623753149 TIAFLLPMFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIAFLLPMFR 10 0 A0A0C4DG89;Q7L014;D6RJA6 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 3144580.0 0.0 2045080.0 1099500.0 False True 0.0 2034062.748123403 1329400.3664863878 0.0 TIAFLLPMFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIAFLLPMFR 10 0 A0A0C4DG89;Q7L014;D6RJA6 A0A0C4DG89 DDX46 Probable ATP-dependent RNA helicase DDX46 0 7321000.0 2794900.0 1366800.0 3159300.0 False True 3618053.1457154695 1290736.3784862398 2584339.817155477 1.0 0.35674887197683686 0.7142901757028847 21.786782169239387 -10.68647199363959 6.899812895575364 1.0031892082750882 0.5355195238400234 0.6923266771465801 0.14596562601637983 0.007191669707916251 0.0003267896926445615 0.14193623908409098 0.04711020322334828 2.0583916258205472e-11 10.68647199363959 -0.46766968443506474 TIAIIAEGIPEALTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIAIIAEGIPEALTR 15 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 22676400.0 4849000.0 12613400.0 5214000.0 False True 6357085.957782796 10731529.88664811 4674505.296219653 1.0 1.6881209343268055 0.7353220213259493 22.59993416538929 -6.712964938297501 1.7849070516312955 1.4217576080614625 0.7373846667484034 0.4790774977603488 0.2898394256624576 0.36913244288022845 2.2942820213199595 0.12914353866806721 0.326877865761955 1.9365783025471484e-07 6.712964938297501 -0.684372941313059 TIAIIAEGIPEALTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIAIIAEGIPEALTR 15 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 33697000.0 11287000.0 11494000.0 10916000.0 False True 10928700.363191446 16083614.140418163 8056772.127019535 1.0 1.4716858918182798 0.7372122813573746 23.38161851068703 -6.733284686848695 1.7114077195960877 1.282814964332839 0.7373922802124543 0.5743808450541421 0.19823891496846893 0.3301034163632116 1.8956088391565598 0.09174217043062666 0.2267969357075076 1.8480567916052854e-07 6.733284686848695 -0.5454226841203847 TIAIIAEGIPEALTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIAIIAEGIPEALTR 15 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 28873000.0 4849000.0 11961000.0 12063000.0 False True 6641806.339297816 11432523.470262347 9213967.845283465 1.0 1.7212973227808708 1.3872683686615264 22.66314422691218 -10.074299687215376 4.45298423329368 0.9999634614286977 1.55428284529864 0.7859320630310618 0.13636674965019074 95429984.42395522 128289764.76388338 51889.64884463282 0.049905120363394416 8.42753010874472e-11 10.074299687215376 0.5543193838699422 TIAIIAEGIPEALTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIAIIAEGIPEALTR 15 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 23648100.0 11287000.0 5132400.0 7228700.0 False True 9385640.598881269 5104750.74249836 8740187.748267535 1.0 0.5438894328754529 0.9312297499767177 23.162023786121306 -10.102372610631196 7.436435955673662 1.0000000554475181 0.7375595914260854 0.37968694254706925 0.15813102228432202 1.4544054516184913e-07 1.7487713333042408e-08 0.15310973589752158 0.051036567985494434 7.900005422173131e-11 10.102372610631196 -0.26244046402143273 TIAMDGTEGLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIAMDGTEGLVR 12 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 42964600.0 7363600.0 19571000.0 16030000.0 False True 9653750.909203848 16651083.087160511 14371369.370617773 1.0 1.7248304046549858 1.4886824308793971 23.20265817146483 -10.17065431942015 4.888458546888929 0.9999464475319572 1.6067564177689369 0.8979837337138886 0.09640700659645414 5.627475797545928e-05 9.547124881730008e-06 0.09335388726758595 0.03111522758295002 6.750651380492004e-11 10.17065431942015 0.6068099702369797 TIAMDGTEGLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIAMDGTEGLVR 12 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 45522500.0 16422000.0 7244500.0 21856000.0 False True 15900692.59894833 10137266.629568424 16131257.93405451 1.0 0.6375361680936402 1.0145003328421953 23.922586271690104 -10.97500576035831 11.883985454856878 1.0877955519208968 0.826018250467928 0.22119476791214754 0.15389497582473563 0.08003664042062991 0.00016833188375263653 0.03331487694641898 0.049669389869516155 1.0592396756307528e-11 10.97500576035831 -0.26177730145296885 TIAMDGTEGLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIAMDGTEGLVR 12 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 22741900.0 4388000.0 12329000.0 6024900.0 False True 6656916.805770224 10128793.623083334 4834075.874192519 1.0 1.521544270209849 0.7261733945664359 22.666422707739077 -6.7298062559926315 1.7240310579000024 1.313927198499183 0.7266687040847176 0.5583685917737506 0.21924719967533227 0.3365793145239002 1.959825055660801 0.10078430613285763 0.2501352765215929 1.8629180215174048e-07 6.7298062559926315 -0.5872584944144653 TIAMDGTEGLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIAMDGTEGLVR 12 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 56507600.0 7363600.0 29768000.0 19376000.0 False True 10086121.913807686 28452751.330387883 14799787.861246146 1.0 2.820980310721475 1.4673417580830102 23.26586823298772 -6.570335027971612 2.3053460029829687 2.2471922380186626 1.470171719510582 0.0 0.7930263098988689 0.728924576087893 7.272921115715006 0.29064877252976423 0.8887950079993624 2.689459272787915e-07 6.570335027971612 -0.7770205185080807 TIAMDGTEGLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIAMDGTEGLVR 12 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 28692400.0 16422000.0 8711400.0 3559000.0 False True 13655620.617952345 8664469.95912248 4303170.445043253 1.0 0.6344984385207469 0.31512082573428374 23.70299154712438 -7.562039255625702 0.25731548339937016 1.1298624643237682 7.471516527936598e-14 0.999819483895444 0.003759445922893707 0.12844969946374696 0.028152509165559482 0.029920249415151038 0.069821203190062 2.741326373831879e-08 7.562039255625702 -1.1298624643236936 down TIAMDGTEGLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TIAMDGTEGLVR 12 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 47155600.0 20424000.0 23275700.0 3455900.0 False True 26439270.617228746 21980386.8340153 2826961.660528472 1.0 0.8313537522359681 0.10692283086986241 24.65617904183545 -7.090800944056236 0.7230335746835884 1.0001698481820254 8.115434339831354e-21 0.9972763250808429 0.02021885130721166 0.07775969364917296 0.06743766918284451 0.01901492596642415 0.05302389653857565 8.113328415755054e-08 7.090800944056236 -1.0001698481820254 down TIAPALVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIAPALVSK 9 0 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 0 152265000.0 34284000.0 66223000.0 51758000.0 False True 44946656.00672825 56342786.53523219 46402578.65779374 1.0 1.2535479063625559 1.0323922351608883 25.421710448650487 -10.58956758636733 3.2210269168726087 0.993189750432861 1.1429700706894663 0.3578332247450563 0.09028642497520831 66414388.66297006 80805012.01732694 3861108.540359409 0.03304144204737345 2.5729563211550225e-11 10.58956758636733 0.14978032025660537 TIAPALVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIAPALVSK 9 0 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 0 193468000.0 82437000.0 38931000.0 72100000.0 False True 79820082.5587324 54476351.32248295 53214847.046363905 1.0 0.6824892881111556 0.6666849411889282 26.250248435255813 TIAPALVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIAPALVSK 9 0 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 0 525814000.0 89043000.0 365360000.0 71411000.0 False True 135084740.9152685 300158653.42929053 57296584.549446814 1.0 2.2220026584465535 0.4241528995890507 27.00928947706983 -6.723684068972613 1.7460225598650925 1.7405237448448538 0.4263554478484068 0.5298093473550414 0.514006766432362 0.3482339288367376 2.07665433949464 0.23356946708172896 0.5838294389852486 1.8893652833261631e-07 6.723684068972613 -1.314168296996447 TIAPALVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIAPALVSK 9 0 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 0 178534000.0 34284000.0 91755000.0 52495000.0 False True 46959721.29026319 87700960.7067905 40096762.16846185 1.0 1.8675783905253875 0.8538543472313084 25.484920510173378 -6.680138983233803 1.9015541823648872 1.548871507317154 0.857727192509052 0.3246478830541405 0.36769149194906253 0.43823931867134164 3.063899455664261 0.1551556789006279 0.40911573679396024 2.0886276197714847e-07 6.680138983233803 -0.6911443148081019 TIAPALVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIAPALVSK 9 0 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 0 144170000.0 82437000.0 45731000.0 16002000.0 False True 68550018.07831796 45484638.026107185 19347944.2151116 1.0 0.6635248144521462 0.2822456471566017 26.03065371069009 -7.308069064120296 0.32626355861225603 1.0617519321460933 6.062751689376944e-13 0.9997914793337277 0.004234052293918744 0.104785117181435 0.024007237854591974 0.01289558534169371 0.05029342599278318 4.919612948167637e-08 7.308069064120296 -1.0617519321454871 down TIAPALVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIAPALVSK 9 0 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 0 232244000.0 89043000.0 71842000.0 71359000.0 False True 115267918.79993649 67843929.5458065 58372394.20517127 1.0 0.588575991066162 0.5064062474007593 26.78041579916228 -13.999999999999973 0.22645689393720467 3.555333108613169 0.46508351581222146 0.9995051648560226 0.004803475855487592 13.183403653472986 0.15070296502397976 15.11759096347971 0.043613834418320736 1.0000000000000614e-14 13.999999999999973 -3.090249592800948 TIAPALVSK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIAPALVSKK 10 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 5230800.0 2082900.0 1689600.0 1458300.0 True False 2730702.070832296 1437518.266009216 1307409.1050013644 1.0 0.5264280865217464 0.47878130645093653 21.380840488927404 -13.999999999999998 0.32459460329054735 5.990559968233839 0.46979954333192103 0.9997035139841574 0.004051225460942843 18.376983023707545 0.18190973611437322 62.43357672412564 0.015583795253565213 1.0000000000000041e-14 13.999999999999998 -5.520760424901918 TIAPALVSK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIAPALVSKK 10 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8;A0A2R8Y6I8 P06733 ENO1 Alpha-enolase;Enolase 1 5445600.0 2082900.0 1681300.0 1681400.0 True False 2853004.4182560197 1607014.6066843981 1284287.949519986 1.0 0.5632709842302773 0.45015280779166955 21.444050550450296 -13.999999999999977 0.18965905462940122 3.3383791756831864 0.36872174767938426 0.9994895982740065 0.005356112406877625 12.345174110070847 0.1381049806749888 10.667047675788227 0.07800420393298665 1.0000000000000532e-14 13.999999999999977 -2.969657428003802 TIAQDYGVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIAQDYGVLK 10 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 847000000.0 198960000.0 542240000.0 105800000.0 False True 301836865.9243492 445473035.4595432 84888583.62621261 1.0 1.4758735123203746 0.2812399451811451 28.169193784440154 -6.798616513403282 1.4616113544961673 1.263021742152285 0.26531694910316683 0.8280745636810437 0.2036107910085333 0.22273681403739137 0.9395608502718529 0.10960026129278638 0.25510120379002116 1.589950071573132e-07 6.798616513403282 -0.9977047930491181 down TIAQDYGVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIAQDYGVLK 10 0 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 0 318740000.0 198960000.0 119780000.0 0.0 False True 257557642.08792794 113114137.70491771 0.0 1.0 0.4391798930442978 0.0 27.940320106532603 -8.131858405811593 0.5577015594293946 1.0221005412108237 1.361537671637135e-16 0.9906595436141421 0.039552758821422035 0.11907872445999451 0.17029945775996919 0.050548750016430236 0.07422609694216634 7.381448502364706e-09 8.131858405811593 -1.0221005412108235 TIAQDYGVLK(ub)ADEGISFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIAQDYGVLKADEGISFR 18 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 24875900.0 6681400.0 6235500.0 11959000.0 True False 6469302.614213459 8725367.667702936 8826579.137690233 1.0 1.3487338880287902 1.3643787690960214 22.625178768521387 -11.907450236127438 0.4838850680417044 9.030993261062083e-13 1.363858883132511 0.9998751828162863 0.0018791885351849913 5.836837233183212 0.2401394009959321 6.011440416679951 0.00328558328873288 1.2375129829186621e-12 11.907450236127438 1.3638588831316079 TIAQDYGVLK(ub)ADEGISFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIAQDYGVLKADEGISFR 18 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 80128000.0 12124000.0 16145000.0 51859000.0 True False 18392994.383126304 13263798.608539233 41609045.919392854 1.0 0.7211331843121431 2.2622225099772177 24.132653034120214 -6.8600687391339745 1.1854321722130112 0.8486784180402235 2.3369320001242504 0.9537209065228076 0.14423819461743573 0.1467291905809628 0.39176979866904726 0.09490057898890321 0.2215369122014836 1.3801657978388613e-07 6.8600687391339745 1.488253582084027 up TIAQDYGVLK(ub)ADEGISFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIAQDYGVLKADEGISFR 18 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 20950400.0 6681400.0 4720500.0 9548500.0 True False 5555880.136206726 4695069.729554112 11545047.202724217 1.0 0.8450631789114998 2.077987091097792 22.405584043955663 -6.875393630782875 1.1052331419264039 0.908760498944019 2.1579766060020718 0.9697729646541341 0.09533524657930759 0.13178539287322208 0.29764741199824774 0.06670188844095343 0.15956715313531145 1.33231331809367e-07 6.875393630782875 1.2492161070580527 up TIAQDYGVLK(ub)ADEGISFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIAQDYGVLKADEGISFR 18 1 Q06830;A0A0A0MSI0 Q06830 PRDX1 Peroxiredoxin-1 1 79048000.0 12124000.0 14508000.0 52416000.0 True False 15694756.99976899 13700617.046443056 42876825.83357752 1.0 0.8729422855444474 2.731920337104208 23.903779356212663 -6.890526006902285 1.0192372798076317 0.9013711632180672 2.89348442697168 0.9812338311722365 0.11616324456971036 0.11871853416139104 0.21934917050833577 0.08677730200977006 0.21675689014603297 1.2866901997176018e-07 6.890526006902285 1.992113263753613 up TIAQGNLSNTDVQAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIAQGNLSNTDVQAAK 16 0 P22695;H3BRG4 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 11321900.0 1722000.0 5816800.0 3783100.0 False True 2257558.6758717205 4948956.113708808 3391661.1020576437 1.0 2.1921716439099184 1.5023578958575716 21.106332054389803 -10.128128073194658 4.839675796042201 0.9999497407407387 1.8472647698870093 0.6679361457765338 0.28161528339861996 196574504.99976355 13.584993948847625 111943.8303329423 0.0964044020320841 7.445123852521277e-11 10.128128073194658 0.8473150291462705 TIAQGNLSNTDVQAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIAQGNLSNTDVQAAK 16 0 P22695;H3BRG4 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 6431900.0 0.0 0.0 6431900.0 False True 0.0 0.0 4747192.437136033 0.0 TIAQGNLSNTDVQAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIAQGNLSNTDVQAAK 16 0 P22695;H3BRG4 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 32800500.0 4490500.0 24918000.0 3392000.0 False True 6812416.799523973 20471188.214777406 2721569.713233585 1.0 3.0049817586334204 0.39950135074291965 22.69973527448317 -6.701172888304174 1.826899589693399 2.2435866546255583 0.4071305988045501 0.42307825401157506 0.8461471074951543 0.39307201083020216 2.5513848050297696 0.36940436253028974 0.9485625280346077 1.9898810294897996e-07 6.701172888304174 -1.8364560558210081 TIAQGNLSNTDVQAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIAQGNLSNTDVQAAK 16 0 P22695;H3BRG4 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 11159000.0 1722000.0 4262900.0 5174100.0 False True 2358669.9353002347 4074550.9824748277 3952084.1439344347 1.0 1.7274782374144175 1.675556246673986 21.169542115912694 -10.46815462393356 4.68979356465994 0.9977520154213799 1.7015172420444247 0.9959082734011424 0.021197063958025893 0.0004995224579093091 5.664828943112925e-05 0.020577467250187036 0.006841322974719149 3.4028701412400844e-11 10.46815462393356 0.7037652266230447 TIAQGNLSNTDVQAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIAQGNLSNTDVQAAK 16 0 P22695;H3BRG4 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 13831500.0 4490500.0 4030500.0 5310500.0 False True 5813040.77098834 3806199.1319057564 4344043.490331443 1.0 0.65476904117062 0.7472927958826038 22.47086159657562 -10.016861438982922 6.9157034671295925 1.0000000474822752 0.7010309185266123 0.9329824292916736 0.037772664688466545 2.7665772489701866e-08 3.9007879771000556e-09 0.03657323104238277 0.01219107510669213 9.619191283172234e-11 10.016861438982922 -0.29896912895566297 TIAQVLVHLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIAQVLVHLHR 11 0 Q99747;Q99747-2 Q99747 NAPG Gamma-soluble NSF attachment protein 0 52326000.0 24353000.0 15938000.0 12035000.0 False True 31927018.83478751 13560112.525837399 10789733.647871798 1.0 0.42472216388278544 0.33794992585137207 24.928274512670455 -13.999999999999998 0.26633167117976064 5.354042775857827 0.30810735095627173 0.9995755029406289 0.006052936438764335 14.70647357910472 0.16334034115168586 34.59382779581194 0.03671150798444636 1.0000000000000041e-14 13.999999999999998 -5.045935424901555 TIAQVLVHLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIAQVLVHLHR 11 0 Q99747;Q99747-2 Q99747 NAPG Gamma-soluble NSF attachment protein 0 58277000.0 26411000.0 14550000.0 17316000.0 False True 25572597.261650477 20359890.87724765 12780420.131135048 1.0 0.7961604630508151 0.4997701250432233 24.608095358471704 -6.965769277193701 0.3445947816591708 1.0304839274715532 0.255527764440789 0.9999281349591821 0.0017410616622449485 0.07770087765633012 0.013944894153113244 0.004127828608434304 0.025569582655088983 1.0820086253401014e-07 6.965769277193701 -0.7749561630307642 down TIAQVLVHLHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIAQVLVHLHR 11 0 Q99747;Q99747-2 Q99747 NAPG Gamma-soluble NSF attachment protein 0 110372000.0 25360000.0 43739000.0 41273000.0 False True 38472974.06434207 35933433.71563321 33115373.45940145 1.0 0.933991576932375 0.860743788718268 25.197342022362655 -6.969785889377766 0.26332699456339026 1.019746809108755 0.7728061484839703 0.9999806269501079 0.00025027527797228294 0.07637288582697754 0.009282234195260699 0.0014968299601805016 0.006877103433948465 1.0720477029904682e-07 6.969785889377766 -0.2469406606247846 TIAQVLVHLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIAQVLVHLHR 11 0 Q99747;Q99747-2 Q99747 NAPG Gamma-soluble NSF attachment protein 0 88521000.0 24353000.0 38838000.0 25330000.0 False True 33356962.215079386 37122008.73990884 19347575.687725283 1.0 1.1128713850066185 0.5800161166648141 24.991484574193347 -6.851353896712813 1.2285847809979848 1.060306563989004 0.5581566807052786 0.9422506041512994 0.05509486289910338 0.15596985922866632 0.4523615348356406 0.03507871677088018 0.08124530512687139 1.4081408687518372e-07 6.851353896712813 -0.5021498832837253 TIAQVLVHLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIAQVLVHLHR 11 0 Q99747;Q99747-2 Q99747 NAPG Gamma-soluble NSF attachment protein 0 44950500.0 26411000.0 9817300.0 8722200.0 False True 21961916.705683786 9764412.25631853 10545971.693103753 1.0 0.44460656085593303 0.48019359304711484 24.38850063390598 -10.388318259889946 7.084985951498759 1.0000249288081586 0.4624000769515243 0.9967243195141199 0.014528345054732435 5.721094259320459e-06 4.939357987327906e-07 0.014067659499254506 0.00468900320374447 4.0896085500254204e-11 10.388318259889946 -0.5376248518566343 TIAQVLVHLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIAQVLVHLHR 11 0 Q99747;Q99747-2 Q99747 NAPG Gamma-soluble NSF attachment protein 0 119040000.0 25360000.0 52903000.0 40777000.0 False True 32829019.920335013 49958901.54452548 33356004.40735247 1.0 1.5217908321892926 1.0160523977961045 24.968468344455104 -10.683081539109327 3.1363455199498165 0.9727637806830847 1.2689216149476272 0.2737821546412651 0.2064668524176334 153217496.80943164 268009320.93432242 35438109.28740384 0.07555913151318124 2.0745239874798965e-11 10.683081539109327 0.29615783426454256 TIATALEYVYK(ub)GQLQSAPS ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIATALEYVYKGQLQSAPS 19 1 P78537-2;G8JLQ3;P78537 P78537-2 BLOC1S1 Biogenesis of lysosome-related organelles complex 1 subunit 1 1 11041800.0 3738400.0 4374500.0 2928900.0 True False 3619726.538296697 6121260.662716127 2161733.224883428 1.0 1.6910837318657101 0.5972089885830589 21.787449278581427 -6.735986041586559 1.7016536293300208 1.4130980121419838 0.5971441981250541 0.5866861649020773 0.29040378554005175 0.3251225679510192 1.8469334005852118 0.13510512896062965 0.3329744163127227 1.8365973714376557e-07 6.735986041586559 -0.8159538140169297 TIATALEYVYK(ub)GQLQSAPS ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIATALEYVYKGQLQSAPS 19 1 P78537-2;G8JLQ3;P78537 P78537-2 BLOC1S1 Biogenesis of lysosome-related organelles complex 1 subunit 1 1 9352900.0 3738400.0 3449200.0 2165300.0 True False 3108645.239200644 3430618.4749874026 2618054.218783973 1.0 1.1035734897397138 0.8421849446729336 21.567854554015703 -6.799174713629848 1.4591188954835035 1.0572050656867282 0.8386427127946872 0.8298012832680577 0.04433878790402457 0.22192621569905832 0.9328647400405912 0.02390590799804839 0.05562849549385034 1.5879078158889252e-07 6.799174713629848 -0.21856235289204107 TIAYGYIHDPSGGPVSLDFVK(ub)SGDYALER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIAYGYIHDPSGGPVSLDFVKSGDYALER 29 1 Q5SYV2;Q9UL12;Q9UL12-2 Q5SYV2;Q9UL12 SARDH Sarcosine dehydrogenase, mitochondrial 1 116503000.0 25802000.0 23861000.0 66840000.0 True False 39143520.37887035 19602818.123156074 53629044.70298731 1.0 0.5007934374174905 1.3700618693441848 25.2222701750242 -6.750957277362635 1.6462500636618553 0.7068020330429841 1.3719225178927816 0.6531111080098704 0.20978057377006987 0.29837350372959076 1.591266914040164 0.10065048648375427 0.24411206304573194 1.7743640209437758e-07 6.750957277362635 0.6651204848497976 TIAYGYIHDPSGGPVSLDFVK(ub)SGDYALER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIAYGYIHDPSGGPVSLDFVKSGDYALER 29 1 Q5SYV2;Q9UL12;Q9UL12-2 Q5SYV2;Q9UL12 SARDH Sarcosine dehydrogenase, mitochondrial 1 97127000.0 25802000.0 15033000.0 56292000.0 True False 33401197.633457504 14196400.33493094 46047433.60469601 1.0 0.42502668589076603 1.3786162433460456 24.99339649711665 -6.743451374539444 1.6740491035194163 0.659264878819638 1.3796069712585846 0.6203195097756593 0.24156975598930588 0.3116172397772152 1.7159660873004716 0.11409799138652721 0.27893372479821554 1.8052968545439054e-07 6.743451374539444 0.7203420924389465 TICMQHGPLLTFHLNLTQGTALIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TICMQHGPLLTFHLNLTQGTALIR 24 0 H0Y720;Q9UPQ9-2;Q9UPQ9-1;Q9UPQ9 H0Y720 TNRC6B Trinucleotide repeat-containing gene 6B protein 0 36928300.0 9118900.0 8147400.0 19662000.0 False True 13834037.980888361 6693432.814073253 15775797.081839265 1.0 0.48383796714453076 1.1403609780191029 23.721718986622882 -6.697032197243036 1.841258629149871 0.6785608779131608 1.1383156214949237 0.40359529438256925 0.21799841816097099 0.4017276935371886 2.645655343427718 0.09452548941729116 0.2440067387800909 2.0089438702332922e-07 6.697032197243036 0.45975474358176294 TICSHVQNMIK ddPTM_RPMI8226_Bortezomib_1h_R1 2 TICSHVQNMIK 11 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7;H0Y9R4 P32969 RPL9 60S ribosomal protein L9 0 82937900.0 18042100.0 29340600.0 35555200.0 False True 23653367.819944944 24963096.84876304 31876288.973561414 1.0 1.0553717778706215 1.3476427211639077 24.49554227658034 -6.938604255649794 0.6724228367389333 0.99662673823899 1.4233247773189899 0.9979753185536551 0.0068625732756983195 0.08840915953620909 0.05755280511457702 0.006611572611820574 0.025313774688470524 1.151849516512828e-07 6.938604255649794 0.4266980390799999 TICSHVQNMIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TICSHVQNMIK 11 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7;H0Y9R4 P32969 RPL9 60S ribosomal protein L9 0 25311400.0 13442000.0 4616500.0 7252900.0 False True 13015291.067778813 6459892.524729458 5353147.907663976 1.0 0.49633100720442835 0.4112968261552327 23.63370424006002 -13.999999999999998 0.2502831583293048 4.507787904604689 0.3771978929982286 0.9995432213778598 0.005552634222132937 14.009260002865398 0.15830667167208973 24.710281062238813 0.03918120209819781 1.0000000000000041e-14 13.999999999999998 -4.13059001160646 TICSHVQNMIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TICSHVQNMIK 11 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7;H0Y9R4 P32969 RPL9 60S ribosomal protein L9 0 136534600.0 38033600.0 76081000.0 22420000.0 False True 57699751.8286104 62503751.12643381 17988677.172964897 1.0 1.0832585781667323 0.31176351029026816 25.782061777945326 -6.88018376443585 1.0788239675988607 1.0517220798297517 0.25690603955705343 0.9738311973838824 0.055929079195408946 0.1274651208010132 0.27133093100331573 0.03993033910357504 0.09660296021374756 1.3176990582923334e-07 6.88018376443585 -0.7948160402726983 down TICSHVQNMIK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TICSHVQNMIK 11 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7;H0Y9R4 P32969 RPL9 60S ribosomal protein L9 0 69845000.0 18042100.0 25238100.0 26564800.0 False True 24712751.939419508 24122997.290764 20290741.359229546 1.0 0.9761356141112401 0.8210636115706573 24.558752338103233 -6.934175160820051 0.7117199475840837 1.0020327664267459 0.7855599531682975 0.9972965255669484 0.004124603061427187 0.09052779031786648 0.06748796374823669 0.0038557722428169653 0.013723586834490218 1.1636566056361645e-07 6.934175160820051 -0.21647281325844836 TICSHVQNMIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TICSHVQNMIK 11 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7;H0Y9R4 P32969 RPL9 60S ribosomal protein L9 0 26874100.0 13442000.0 5577900.0 7854200.0 False True 11177618.581568358 5547850.745573538 9496476.906282296 1.0 0.49633566444303434 0.8495975092531582 23.414109515494296 -10.097797448743467 6.033357727011449 1.0000011783692289 0.6729665868480905 0.533297559726581 0.14421854422987299 2.2859773633855524e-06 3.4177836505744004e-07 0.13963950851675905 0.04654633500137701 7.98366952014053e-11 10.097797448743467 -0.32703459152113834 TICSHVQNMIK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TICSHVQNMIK 11 0 P32969;D6RAN4;E7ESE0;A0A2R8Y5Y7;H0Y9R4 P32969 RPL9 60S ribosomal protein L9 0 85718700.0 44998800.0 16628000.0 24091900.0 False True 58251833.65895782 15702637.18281326 19707421.403769165 1.0 0.26956468486032886 0.3383141811320236 25.79580012803937 -10.263648084915445 5.452784380789388 1.000067216945729 0.3039394329961396 0.9927365944760775 0.02806686432330005 2.293689900824353e-05 3.097425948624006e-06 0.02717822897203993 0.009058541508681664 5.44944050009032e-11 10.263648084915445 -0.6961277839495894 TIDDLEDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIDDLEDK 8 0 J3KN67;P06753-7;P06753-2;P06753-5;A0A087WWU8 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 8700300.0 1155100.0 3945600.0 3599600.0 False True 1514347.286004311 3356931.8598283427 3227147.921801353 1.0 2.216751659842699 2.1310487704021717 20.530264666550938 -10.136779480386618 4.614564815809429 0.9998818793932921 2.173900215139439 0.9960184038678916 0.034988058238501686 12221700.236802677 3.8227006516512576 15838.757908422585 0.011977342941677368 7.298279974268247e-11 10.136779480386618 1.1740183357461467 TIDDLEDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIDDLEDK 8 0 J3KN67;P06753-7;P06753-2;P06753-5;A0A087WWU8 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 10930400.0 3302100.0 1523700.0 6104600.0 False True 3197276.6429781574 2132121.355990531 4505622.125925568 1.0 0.6668554504575276 1.4092062179920504 21.608412147407485 -6.784686852597576 1.5173387032503658 0.8125126220879912 1.4160030313802012 0.7837033970012708 0.14119422755636704 0.24336289959789184 1.1068721638400192 0.07326631932231759 0.17223291942368102 1.6417731446442984e-07 6.784686852597576 0.60349040929221 TIDDLEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIDDLEDK 8 0 J3KN67;P06753-7;P06753-2;P06753-5;A0A087WWU8 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 7831300.0 1155100.0 3340900.0 3335300.0 False True 1582171.6854037747 3193287.9911210993 2547570.8326596967 1.0 2.018294234804337 1.6101734446154934 20.59347472807383 -10.15883066373729 4.939316967151761 0.9999450714737149 1.8142338396260043 0.8414492398445489 0.16661461490890775 0.00010460634170033005 1.7814834242880495e-05 0.16133513181791873 0.0537746357297301 6.936962331908196e-11 10.15883066373729 0.8142887681522893 TIDDLEDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIDDLEDK 8 0 J3KN67;P06753-7;P06753-2;P06753-5;A0A087WWU8 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 5626670.0 3302100.0 1597300.0 727270.0 False True 2745842.457833422 1588695.027860772 879338.7944834532 1.0 0.5785820025211189 0.32024371681443303 21.38881742284176 -8.663268487291093 0.18842388026922505 1.3622569202281232 3.605684370713106e-12 0.999730908870429 0.004595720019165847 0.23894063924045178 0.05217141707177028 0.18529646515266332 0.13620798128104716 2.1713583978711706e-09 8.663268487291093 -1.3622569202245174 down TIDDLEDKLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIDDLEDKLK 10 1 J3KN67;P06753-7;P06753-2;P06753-5;A0A087WWU8 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 9580100.0 1321200.0 5049800.0 3209100.0 False True 1732105.994518999 4296389.523966225 2877053.1158608506 1.0 2.480442615845412 1.6610144673391076 20.72409578639112 -10.154357086318726 6.607084894950825 0.9999972302229354 2.0707285415922607 0.6948002236090557 0.3345301407856698 1.3648962638064963e-05 1.7466783859298717e-06 0.3239082552623747 0.10796913867227641 7.008787837419388e-11 10.154357086318726 1.0707313113693253 TIDDLEDKLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIDDLEDKLK 10 1 J3KN67;P06753-7;P06753-2;P06753-5;A0A087WWU8 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 12683300.0 4394900.0 2774600.0 5513800.0 False True 4255386.3051466355 3882512.2493478544 4069570.3695456437 1.0 0.9123759797441158 0.9563339442587718 22.020858675435576 -10.199393811219577 4.627420319204799 1.0000129556838426 0.934354962000923 0.7483324477168567 0.01794576386716061 2.3991061039557435e-06 4.1508839268898616e-07 0.017379340111356497 0.005791970382455509 6.318386504508027e-11 10.199393811219577 -0.06565799368291958 TIDDLEDKLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIDDLEDKLK 10 1 J3KN67;P06753-7;P06753-2;P06753-5;A0A087WWU8 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 50849600.0 6347300.0 38907000.0 5595300.0 False True 9629318.149787005 31963741.868221488 4489386.502492889 1.0 3.319419025419625 0.4662206017766888 23.19900221404421 -6.69051832032607 1.8643932385213295 2.453462614389627 0.47600231608030735 0.37280003232507053 0.9808570685788658 0.4156335103027418 2.801428838208677 0.42078963952548487 1.095123110128801 2.0393026316281824e-07 6.69051832032607 -1.97746029830932 TIDDLEDKLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIDDLEDKLK 10 1 J3KN67;P06753-7;P06753-2;P06753-5;A0A087WWU8 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 8776600.0 1321200.0 4145000.0 3310400.0 False True 1809683.3440874966 3961860.194317986 2528551.699828101 1.0 2.189256041540068 1.3972343327849337 20.787305847914013 -10.171698422744003 4.789092626575363 0.9999337856977586 1.79324518715832 0.5721844337594062 0.323341508816574 0.0002956284366563984 5.1131037451979156e-05 0.31310757578374476 0.10435802320094338 6.734441384759008e-11 10.171698422744003 0.7933114014605613 TIDDLEDKLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIDDLEDKLK 10 1 J3KN67;P06753-7;P06753-2;P06753-5;A0A087WWU8 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 18371700.0 6347300.0 5836200.0 6188200.0 False True 8216704.973988268 5511410.339567878 5062011.096293963 1.0 0.6707567518872131 0.6160633870047468 22.97012853613666 -13.999999999999998 0.2525845307384696 3.3198933473535726 0.5946064407007529 0.9995476057382924 0.00360677211983303 14.102018552527708 0.1590312824113854 16.624541947377168 0.0248832890991547 1.0000000000000041e-14 13.999999999999998 -2.7252869066528196 TIDDLEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIDDLEEK 8 0 P67936;A0A2R8YE05;K7ENT6;P67936-2;A0A5F9UN72;K7EPB9 P67936 TPM4 Tropomyosin alpha-4 chain 0 4170750.0 1558700.0 668450.0 1943600.0 False True 1509219.9216892426 935365.5709206985 1434512.8532498323 1.0 0.6197675749427961 0.9504995479016789 20.525371618271944 -10.17508595136537 7.52871939190033 1.0000001323189942 0.7851335614222374 0.3601066493715255 0.13502076256220447 2.9981993892443766e-07 3.286165634414071e-08 0.1307333710694477 0.04357776373297032 6.68211658489733e-11 10.17508595136537 -0.21486657089675676 TIDEK(ub)EELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIDEKEELR 9 1 A0A0D9SG79;Q9NZ09-2;Q9NZ09;Q9NZ09-3;Q9NZ09-4 A0A0D9SG79 UBAP1 Ubiquitin-associated protein 1 1 12053600.0 2059400.0 3948600.0 6045600.0 True False 3124260.3623070167 3243941.4794473886 4850684.510119393 1.0 1.0383070241469878 1.552586515720972 21.575083255760955 -6.9218362729302845 0.8109716525133854 0.9893871927193717 1.6391316163185856 0.9946766103629061 0.01838255958720171 0.09710254309715771 0.10009652499117369 0.015994654020793368 0.048787464917158116 1.197191782168667e-07 6.9218362729302845 0.6497444235992139 TIDEK(ub)EELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIDEKEELR 9 1 A0A0D9SG79;Q9NZ09-2;Q9NZ09;Q9NZ09-3;Q9NZ09-4 A0A0D9SG79 UBAP1 Ubiquitin-associated protein 1 1 11440400.0 2059400.0 3803100.0 5577900.0 True False 2665933.8968429742 3591454.1418064195 4562779.434087146 1.0 1.347165489009107 1.7115125920753083 21.346209577853404 -6.970515673211657 0.2455598744043873 0.8778703776534763 2.1914191700440213 0.9999861289381516 0.001081926703629558 0.07613575524061397 0.008429372423751826 0.008377037875464571 0.03517838488956088 1.0702477581463396e-07 6.970515673211657 1.3135487923905451 TIDGQQTIIACIESHQFQPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIDGQQTIIACIESHQFQPK 20 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 18732600.0 4172200.0 9160300.0 5400100.0 False True 5469794.60364228 7793618.9465697445 4841349.453416911 1.0 1.4248467285005644 0.8851062616122927 22.383055228691134 -6.69682654094049 1.8422744230663741 1.264628094242579 0.8868077598567988 0.40252312555302283 0.17943903241449233 0.4021435334070015 2.651237299875686 0.07777245157160965 0.20079094422695468 2.0098954130763708e-07 6.69682654094049 -0.3778203343857801 TIDGQQTIIACIESHQFQPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIDGQQTIIACIESHQFQPK 20 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 93153000.0 13114000.0 62173000.0 17866000.0 False True 19894896.761821058 51077742.390133806 14334777.269054035 1.0 2.567379112424128 0.7205253407779894 24.245895076859913 -6.681836594192281 1.8953941765534195 1.9900553563449712 0.7274544104718697 0.3325579858375579 0.6640262790842355 0.4344428109331587 3.0191172789357474 0.2809537865443304 0.7392490975790961 2.0804793322246897e-07 6.681836594192281 -1.2626009458731016 TIDGQQTIIACIESHQFQPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIDGQQTIIACIESHQFQPK 20 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 20387900.0 4172200.0 6443300.0 9772400.0 False True 5714775.089465537 6158613.700856237 7464360.388895635 1.0 1.0776651057027353 1.3061512084098001 22.446265290214026 -6.951889054705819 0.5377036114726728 0.996584340090364 1.3977420728209784 0.9993413201067308 0.0033349473816319287 0.08273591844139319 0.03289060007782243 0.003679741900990081 0.018915114322443343 1.1171485992074707e-07 6.951889054705819 0.4011577327306144 TIDGQQTIIACIESHQFQPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIDGQQTIIACIESHQFQPK 20 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 14296700.0 9872500.0 0.0 4424200.0 False True 8209421.175906377 0.0 5349279.764810448 1.0 0.0 0.6516025490944373 22.96884907438598 -10.307965602082005 7.542573183513334 1.0000040650681923 0.3258012745472187 0.5880384504713476 0.26601562672969936 1.8184197638514892e-05 1.6690618858652117e-06 0.2575700723280217 0.08585617434625449 4.9207850878977264e-11 10.307965602082005 -0.6742027905209735 TIDGQQTIIACIESHQFQPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIDGQQTIIACIESHQFQPK 20 0 P52907 P52907 CAPZA1 F-actin-capping protein subunit alpha-1 0 43541000.0 13114000.0 17303000.0 13124000.0 False True 16976331.51558649 16340072.839440595 10735566.663611704 1.0 0.9625208381703828 0.6323843672441865 24.017021398952362 -6.928350398561456 0.7602121956717465 1.0053397084926896 0.5673712863481951 0.9962039379700548 0.010176605542598686 0.09350358939498539 0.0819435803343199 0.009181965783028002 0.030147199390404986 1.1793687104696654e-07 6.928350398561456 -0.4379684221444945 TIDLGAAAHYTGDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIDLGAAAHYTGDK 14 0 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 0 10508400.0 3480000.0 3861100.0 3167300.0 False True 4562313.700367938 3285038.9304499216 2839578.1788869393 1.0 0.7200379338634677 0.6223987137618212 22.12133421772905 -13.999999996559664 0.14687902161426147 2.3476516897895054 0.5110237739990109 0.9995769878515173 0.0032914341017111037 11.947391621463442 0.12053014397554877 4.59999084619348 0.10009924229999778 1.0000000079216664e-14 13.999999996559664 -1.8366279157904946 TIDLGAAAHYTGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIDLGAAAHYTGDK 14 0 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 0 8731600.0 3480000.0 1396500.0 3855100.0 False True 4766650.04346389 1334798.0123920543 2944604.7782767317 1.0 0.28002853161464025 0.6177514085210477 22.18454427925194 -10.58880832392083 6.5173370653454405 1.0011517641687933 0.44888997006934067 0.7802458592972099 0.13787478714757848 0.002311516371624934 0.00014583791820767217 0.13373560283998953 0.04449889620703865 2.577458468546539e-11 10.58880832392083 -0.5522617940994525 TIDLGAAAHYTGDK(ub)ASPDQNASTHTPQSSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIDLGAAAHYTGDKASPDQNASTHTPQSSVK 31 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 42612800.0 13417200.0 20022500.0 9173100.0 True False 17590079.13234963 17035221.047093716 8223955.606588518 1.0 0.9684561916361432 0.46753374698945926 24.06825863727676 -6.919744529295904 0.8266215666991809 1.0111547464396933 0.38722888623951873 0.9941095772852153 0.018720041249836013 0.09832246739115243 0.10639580837699038 0.01610741596658366 0.04813200190520792 1.202971866347738e-07 6.919744529295904 -0.6239258602001745 down TIDLGAAAHYTGDK(ub)ASPDQNASTHTPQSSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIDLGAAAHYTGDKASPDQNASTHTPQSSVK 31 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 84143600.0 29613600.0 17847000.0 36683000.0 True False 28673532.477665074 24973400.170875505 27074621.83358902 1.0 0.8709565237672845 0.9442374027224756 24.773216314659322 -10.173623815567383 4.4008988522059616 1.0000163976912417 0.9075969632459795 0.6794841717734679 0.029916793702587995 6.26069907886987e-06 1.1755869602888305e-06 0.028973494498226976 0.009655603626708819 6.704651126109866e-11 10.173623815567383 -0.09241943444526224 TIDLGAAAHYTGDK(ub)ASPDQNASTHTPQSSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIDLGAAAHYTGDKASPDQNASTHTPQSSVK 31 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 172664400.0 31915000.0 25016400.0 115733000.0 True False 48417388.29903299 20552027.965974674 92858321.82242422 1.0 0.4244761786621428 1.9178713492127542 25.529021924679032 -6.80222511717204 1.4466759211541986 0.6833314744581265 1.9396623685664012 0.8385851299850513 0.24708236993857305 0.21762254252260907 0.8989150839331592 0.13434212135964096 0.3120354019115989 1.5767937245249812e-07 6.80222511717204 1.2563308941082747 TIDLGAAAHYTGDK(ub)ASPDQNASTHTPQSSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIDLGAAAHYTGDKASPDQNASTHTPQSSVK 31 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 38483800.0 13417200.0 11071900.0 13994700.0 True False 18377901.42619647 10582706.848122874 10689440.089893747 1.0 0.5758386990278407 0.5816463937855638 24.13146869879965 -10.221860332285553 6.003480536888881 1.0000089743049365 0.5787425464069545 0.9998574673690558 0.002370981456384296 2.8480119650370827e-07 3.69167747715338e-08 0.0022957417723502133 0.0007652309745607522 5.999839981645282e-11 10.221860332285553 -0.42126642789798197 TIDLGAAAHYTGDK(ub)ASPDQNASTHTPQSSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIDLGAAAHYTGDKASPDQNASTHTPQSSVK 31 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 71514400.0 29613600.0 25514400.0 16386400.0 True False 24625020.504919812 25376948.862988114 19812720.477846827 1.0 1.0305351363227524 0.8045768113731504 24.5536215900936 -6.872806161165477 1.1192019046932369 1.0175986558005548 0.7906216008961657 0.967401671775606 0.018073030357309797 0.13418979233112896 0.3124591602591905 0.012510104527326382 0.029769944228677535 1.3402747593311052e-07 6.872806161165477 -0.22697705490438902 TIDLGAAAHYTGDK(ub)ASPDQNASTHTPQSSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIDLGAAAHYTGDKASPDQNASTHTPQSSVK 31 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 155483000.0 31915000.0 26698000.0 96870000.0 True False 41314596.63870235 25212232.83057185 79240653.97013605 1.0 0.6102500056106984 1.917982030978021 25.30014824677148 -6.826827779053372 1.341900524563739 0.7912348761171606 1.9509741952412396 0.8993941706757032 0.17388199506445345 0.18476604578018357 0.651775782752297 0.1017680034323156 0.2342650651026783 1.4899518060067975e-07 6.826827779053372 1.159739319124079 TIDQIHK(ub)EAEMEEHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIDQIHKEAEMEEHR 15 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;H7C044 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 5178900.0 1721200.0 1431800.0 2025900.0 True False 1666561.4481372475 2003525.2067383623 1495256.0143027552 1.0 1.202191019705722 0.8972102504675336 20.66844308166494 -6.727962689628662 1.730820827623829 1.1219521788454958 0.8974629018031861 0.549765420664371 0.08501044511900319 0.3400493298860869 1.9948056730212274 0.038938867755625654 0.0968418581661038 1.8708428581423259e-07 6.727962689628662 -0.2244892770423097 TIDQIHK(ub)EAEMEEHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIDQIHKEAEMEEHR 15 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;H7C044 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 5623400.0 1721200.0 2176200.0 1726000.0 True False 1431254.0620886362 2164476.3786581215 2086898.6198776783 1.0 1.5122936143842207 1.4580909673243174 20.448848357099216 -10.434922381842807 5.936068262508694 0.9997854272453057 1.4851922908542692 0.9907268256641423 0.02212813800082238 6.286492644268467e-05 5.984332426402751e-06 0.021434766848210572 0.007141825829980277 3.673479479427643e-11 10.434922381842807 0.48540686360896346 TIDQIHK(ub)EAEMEEHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIDQIHKEAEMEEHR 15 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;H7C044 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 9006800.0 2591700.0 2852400.0 3562700.0 True False 3355006.740044643 2693661.4325388856 2914325.156389013 1.0 0.8028780986899128 0.868649568301682 21.677884234056403 -10.346149657446704 7.840419971027298 1.0000012274604726 0.8357638334957974 0.892632802191165 0.026851090030300725 5.761308615810152e-07 4.80287306530652e-08 0.02599865059556669 0.008666152042905897 4.5066138031708475e-11 10.346149657446704 -0.16423739396467518 TIEAEAAHGTVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIEAEAAHGTVTR 13 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 8937900.0 1611500.0 4302000.0 3024400.0 False True 2112692.105788201 3660158.3690646617 2711464.10009335 1.0 1.732461800295852 1.283416590929022 21.010651100052506 -10.273682653156294 4.5200445210447935 0.9997352571498455 1.5079391956156494 0.6304524743870352 0.18332193907595595 0.000489335494606886 7.863017510686683e-05 0.17759184003383083 0.05916690141809514 5.324972225031195e-11 10.273682653156294 0.5082039384658039 TIEAEAAHGTVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIEAEAAHGTVTR 13 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 10113800.0 2614300.0 1975800.0 5523700.0 False True 2531310.477495472 2764747.243660882 4076877.2625520146 1.0 1.0922197289667828 1.610579697274337 21.271453041163074 -6.937231693289864 0.6848343090834885 0.993809671318061 1.7396703496286816 0.9977783550618714 0.012667057588667653 0.0890525317143785 0.060533084987721704 0.012085686849215507 0.04518517093731887 1.1554956283022089e-07 6.937231693289864 0.7458606783106206 TIEAEAAHGTVTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIEAEAAHGTVTR 13 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 31150100.0 3510500.0 24860400.0 2779200.0 False True 5325685.151927159 20423867.384808265 2229889.9018333694 1.0 3.834974618696274 0.41870479350933065 22.34453571000567 -6.686428252086126 1.8794397118254025 2.783308592895905 0.4311237606754895 0.3536068692972356 1.1998852808355267 0.42439836014704974 2.9036968860885577 0.5113108789281973 1.337351407285297 2.0585989546848763e-07 6.686428252086126 -2.3521848322204155 TIEAEAAHGTVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIEAEAAHGTVTR 13 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 10692930.0 1611500.0 4120280.0 4961150.0 False True 2207315.099150019 3938232.4056560965 3789428.548091524 1.0 1.7841731826926792 1.71675922008178 21.073861161575397 -10.155797471088501 4.287324228792578 0.9998199949525977 1.750466201437962 0.9939844090594401 0.027521635165060863 9631635.864324834 6.010717475759126 17142.076230986946 0.00942138772365705 6.985580937483247e-11 10.155797471088501 0.7506462064853643 TIEAEAAHGTVTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIEAEAAHGTVTR 13 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 5566070.0 2614300.0 1993400.0 958370.0 False True 2173906.2831270755 1982661.1585410817 1158760.7359977819 1.0 0.9120269691152944 0.5330315961601398 21.05185831659735 -6.943173531886907 0.6293464459068782 1.0041342248661431 0.42052139058948007 0.9985507351960774 0.0077129806611451225 0.08634819787181731 0.04823719958867412 0.007702633390785236 0.032191242888323555 1.1397942667588106e-07 6.943173531886907 -0.5836128342766631 TIEAEAAHGTVTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIEAEAAHGTVTR 13 0 P48735;P48735-2;H0YL11 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 10421480.0 3510500.0 3295980.0 3615000.0 False True 4544411.452300315 3112555.8156007235 2957107.0930323303 1.0 0.6849194550870153 0.6507128863816867 22.11566203209812 -13.999999999999998 0.31357225350641044 4.1101722936564995 0.6434239502909155 0.9996798183489475 0.00281312899107689 17.528218451019118 0.1783122825281098 35.640011845768285 0.011683057976239771 1.0000000000000041e-14 13.999999999999998 -3.466748343365584 TIECISLIGLAVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIECISLIGLAVGK 14 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 4166600.0 1485600.0 1095000.0 1586000.0 False True 1947635.9865708642 931630.2682765705 1421895.933986261 1.0 0.4783390092913922 0.730062467417099 20.893292632041017 -10.081525711628213 5.168496587019952 1.0000070850627374 0.6042007383534392 0.7672475774398547 0.1027656714522903 8.3900489213905e-06 1.491075469034788e-06 0.09950421428041127 0.0331674778409733 8.28846844425201e-11 10.081525711628213 -0.39580634670929815 TIECISLIGLAVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIECISLIGLAVGK 14 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 6291700.0 1485600.0 1757500.0 3048600.0 False True 2034866.4668304464 1679847.8387246958 2328583.467887852 1.0 0.8255322234196844 1.1443421501337656 20.95650269356391 -6.758124958693547 1.6196385171885737 0.8984229387431365 1.1453957429488597 0.6832253437480221 0.07336294800094119 0.28607811986109966 1.4786429060866142 0.03574710469710362 0.08606195409717239 1.7453199032195617e-07 6.758124958693547 0.2469728042057232 TIEK(ub)FEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIEKFEK 7 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 68578000.0 27413000.0 25651000.0 15514000.0 True False 35938708.46786964 21823970.786814887 13908760.100796273 1.0 0.6072552887181858 0.3870133539504112 25.099035227748324 -9.682475010022081 0.138445314331521 1.656553331039145 2.057166197978013e-10 0.9998227014401101 0.0033758662246166186 1.1588718233422493 0.058063332230135586 0.49029125102320015 0.20365574207790563 2.0774232602891364e-10 9.682475010022081 -1.6565533308334284 TIEK(ub)FEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIEKFEK 7 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 65557000.0 22384000.0 26960000.0 16213000.0 True False 21673432.172382142 37725268.594542675 11966328.920425754 1.0 1.740622726224919 0.5521197023734025 24.369424298768745 -6.7382110074574975 1.6932714419960468 1.4415935235333655 0.5517044204973304 0.5967977384027476 0.31119580892855603 0.32110229472156554 1.8070140024828947 0.14543251834212753 0.35757808728102614 1.8272122263088776e-07 6.7382110074574975 -0.8898891030360351 TIEK(ub)FEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIEKFEK 7 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 68944000.0 27413000.0 21473000.0 20058000.0 True False 37548326.90847003 20524251.858284738 15320713.507477053 1.0 0.5466089583249832 0.4080265292465283 25.162245289271215 -13.999999999999998 0.1660303481794528 3.2636833995177095 0.28046783623472693 0.9995218193205563 0.005528208076147638 12.055350175462575 0.1289441220878677 8.786885230572434 0.11720247076975507 1.0000000000000041e-14 13.999999999999998 -2.9832155632829824 TIEK(ub)FEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIEKFEK 7 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 75932700.0 22384000.0 44098000.0 9450700.0 True False 18613287.779335365 43860435.32123238 11426797.67490034 1.0 2.356404512797928 0.6139053890085163 24.14982957420302 -6.698964996965456 1.8346287903247962 1.8431217765922905 0.6191977866469481 0.41266299398556117 0.5726632830661645 0.3976649342121299 2.6014990893192262 0.24909282008147252 0.6414044739007722 2.0000230599265645e-07 6.698964996965456 -1.2239239899453422 TIEK(ub)FEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIEKFEK 7 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 103881000.0 37996000.0 37322000.0 28563000.0 True False 49186571.01313281 35244997.89132532 23364827.081129324 1.0 0.7165573278510288 0.4750245158356519 25.55176114690479 -7.028969843691941 0.17681889456890384 1.1985326397105354 3.478139347374195e-09 0.9999971529090339 0.0003619675566570357 0.07209170177996699 0.00556027132874701 0.009790268053970121 0.02679080448159207 9.354706286017919e-08 7.028969843691941 -1.198532636232396 down TIEKFEK(ub)EAAEMGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIEKFEKEAAEMGK 14 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 24453100.0 4662100.0 5106000.0 14685000.0 True False 7072746.545164396 4194794.406639908 11782503.313335858 1.0 0.5930927087310756 1.6659020987245048 22.753839131972434 -6.80393176905433 1.4397954902993542 0.7765940046043739 1.6821895355852812 0.8433981528679081 0.17499415458575324 0.2152026710438786 0.8802875275112111 0.09559739490804052 0.22181467350685044 1.5706095395809918e-07 6.80393176905433 0.9055955309809073 TIEKFEK(ub)EAAEMGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIEKFEKEAAEMGK 14 2 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01;A0A2U3TZH3;Q05639;A0A2R8Y488;A0A2R8Y660;A0A2R8YDN5 P68104;A0A2U3TZH3 EEF1A1;EEF1A1P5;EEF1A2 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha;Elongation factor 1-alpha 2 1 30893200.0 4662100.0 7479100.0 18752000.0 True False 6035180.35373004 7062881.510342713 15339328.41176824 1.0 1.170285077889595 2.541652032368474 22.524965454064883 -6.929972354191969 0.7470211915834315 0.9791247156649349 2.82298662793962 0.9965328054739242 0.04063599671498651 0.09265204345973513 0.07775095582287089 0.037015344672934325 0.1241037635514396 1.1749723475686175e-07 6.929972354191969 1.843861912274685 up TIESANQQTDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIESANQQTDK 11 0 O76094;O76094-2;D6RDY6;R4GNC1 O76094 SRP72 Signal recognition particle subunit SRP72 0 4143580.0 383880.0 2022500.0 1737200.0 False True 503270.39749920793 1720750.8836432518 1557451.2083990774 1.0 3.4191378872943945 3.094660874428897 18.940974215055064 -9.956146843533553 5.7857460605711095 0.9999979392903914 3.256899380862897 0.9847340548658122 0.13246718580159297 3.521418258657219e-06 6.355658651923733e-07 0.12826091952704058 0.04275360037673112 1.106249675891337e-10 9.956146843533553 2.2569014415725057 TIESANQQTDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIESANQQTDK 11 0 O76094;O76094-2;D6RDY6;R4GNC1 O76094 SRP72 Signal recognition particle subunit SRP72 0 2606990.0 939000.0 691150.0 976840.0 False True 909191.9589826133 967129.7992996362 720976.2994281562 1.0 1.0637245410549554 0.7929857851304905 19.794225399257765 -6.844670752110452 1.2606080522463607 1.0339071969506446 0.7832300374178061 0.9321748696381267 0.030099113536217588 0.16341731275923047 0.5024362430646965 0.018706839990601656 0.043164517519736594 1.4299776441619783e-07 6.844670752110452 -0.25067715953283853 TIESANQQTDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIESANQQTDK 11 0 O76094;O76094-2;D6RDY6;R4GNC1 O76094 SRP72 Signal recognition particle subunit SRP72 0 3020480.0 383880.0 1094100.0 1542500.0 False True 525810.8099669303 1045759.04429513 1178193.2687846902 1.0 1.988850408687681 2.240717091493022 19.004184276577956 -10.5675988770737 0.2853647495038794 3.147530084362799e-14 2.332633231842407 0.999108025508777 0.015992586881378647 2.1887709161940987 0.14036568529552512 1.6513896842345708 0.09626502290451565 2.7064569469348056e-11 10.5675988770737 2.3326332318423755 TIFAYFTGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIFAYFTGSK 10 0 Q9BRA2;I3L0K2;I3L3M7 Q9BRA2 TXNDC17 Thioredoxin domain-containing protein 17 0 100492000.0 29685000.0 31428000.0 39379000.0 False True 38917322.46994889 26739064.90538451 35304438.83004096 1.0 0.6870736013771718 0.907165153956886 25.21390911964899 -10.10737146249673 5.474762590923867 1.0000026321536009 0.797119378910949 0.5311671209215048 0.08985200008644607 2.886721240772147e-06 4.707559810643982e-07 0.08699995275724207 0.028999608329817936 7.80959545391884e-11 10.10737146249673 -0.20288325324265188 TIFAYFTGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIFAYFTGSK 10 0 Q9BRA2;I3L0K2;I3L3M7 Q9BRA2 TXNDC17 Thioredoxin domain-containing protein 17 0 116854000.0 46246000.0 21816000.0 48792000.0 False True 44777946.04378052 30527242.568937074 36011911.47137567 1.0 0.6817472721747849 0.8042332141846327 25.416285017761304 -10.353087839136833 5.861802794821446 1.0000414836736644 0.7429902431797099 0.8544474269322284 0.05000467643137788 2.7113867614459243e-05 2.992285150781282e-06 0.04842461961080386 0.01613893992093451 4.435189300122629e-11 10.353087839136833 -0.25705124049395456 TIFAYFTGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIFAYFTGSK 10 0 Q9BRA2;I3L0K2;I3L3M7 Q9BRA2 TXNDC17 Thioredoxin domain-containing protein 17 0 128072000.0 34268000.0 43105000.0 50699000.0 False True 51987061.32637511 35412575.969097815 40678320.42783886 1.0 0.6811805681182368 0.7824700875562113 25.631649270485028 -10.59421779810219 9.331729465081272 1.0000438296526137 0.7318253278372241 0.9033481973090798 0.0413512731524593 3.771307451757894e-05 1.639932454839577e-06 0.040044706407412346 0.01334606602199573 2.545553340829037e-11 10.59421779810219 -0.26821850181538964 TIFAYFTGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIFAYFTGSK 10 0 Q9BRA2;I3L0K2;I3L3M7 Q9BRA2 TXNDC17 Thioredoxin domain-containing protein 17 0 113950000.0 29685000.0 30040000.0 54225000.0 False True 40660346.706961334 28712733.471004214 41418171.79893027 1.0 0.7061605666556796 1.018637939745831 25.27711918117188 -11.048081956236283 12.299898294439256 1.5370614302180352 0.8623992531993487 0.20543430920817674 0.12756835337269298 0.041015582119024264 0.0001603356454128841 0.00269654897444325 0.041172509009628565 8.951958161249638e-12 11.048081956236283 -0.6746621770186865 TIFAYFTGSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIFAYFTGSK 10 0 Q9BRA2;I3L0K2;I3L3M7 Q9BRA2 TXNDC17 Thioredoxin domain-containing protein 17 0 90223000.0 46246000.0 21114000.0 22863000.0 False True 38455598.045172535 21000254.691199116 27643547.593431845 1.0 0.546090966171708 0.7188432633646699 25.19669029319558 -10.111277410349091 5.438463680277811 1.000005395238839 0.6324671147680482 0.8578553313606241 0.0705258300032263 4.613584114068365e-06 7.538548582435463e-07 0.06828734324246485 0.022762113756590985 7.739672598234372e-11 10.111277410349091 -0.36753828047079085 TIFAYFTGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIFAYFTGSK 10 0 Q9BRA2;I3L0K2;I3L3M7 Q9BRA2 TXNDC17 Thioredoxin domain-containing protein 17 0 168602000.0 34268000.0 76030000.0 58304000.0 False True 44360601.523266524 71798863.6642586 47693270.249559276 1.0 1.6185277295349814 1.0751267704191254 25.402775592577477 -10.53629099737907 6.784529982850327 0.9997522203811805 1.3468272499770535 0.3519772598703049 0.2218425125954717 0.0008320235683085278 5.686685290835842e-05 0.21494831347807622 0.07159936306358926 2.9087674562980574e-11 10.53629099737907 0.347075029595873 TIFLLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIFLLHR 7 0 Q99598;C4P0D6;C4P0D8;Q5VVQ1;C4P0D4 Q99598 TSNAX;DISC1 Translin-associated protein X 0 10469700.0 4117000.0 1754200.0 4598500.0 False True 3986308.0885318615 2454661.2080321503 3394014.897957065 1.0 0.6157730796307292 0.8514181098348234 21.92662178492526 -10.356414593871385 5.846856457282142 1.000045982217824 0.7335955947327758 0.6301964999133485 0.0962016807371286 5.767291148065963e-05 6.348149908021402e-06 0.09316291867430179 0.031048958947671543 4.401344939213194e-11 10.356414593871385 -0.26645038748504823 TIFLLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIFLLHR 7 0 Q99598;C4P0D6;C4P0D8;Q5VVQ1;C4P0D4 Q99598 TSNAX;DISC1 Translin-associated protein X 0 9936400.0 4117000.0 3469700.0 2349700.0 False True 3423467.914024465 3451008.0374184772 2841011.406214702 1.0 1.008044510445444 0.8298635995904355 21.707027060359536 -6.896328517814727 0.9842054769776478 1.008172684901557 0.812495732075172 0.9846488955671578 0.010180186850443912 0.11415785124126271 0.19306091348884924 0.0078082812600008085 0.019965888052967926 1.2696133552698554e-07 6.896328517814727 -0.1956769528263851 TIFLLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIFLLHR 7 0 Q99598;C4P0D6;C4P0D8;Q5VVQ1;C4P0D4 Q99598 TSNAX;DISC1 Translin-associated protein X 0 16349300.0 4219300.0 5484100.0 6645900.0 False True 5461967.024837118 5178905.01408866 5436414.392692547 1.0 0.9481758111205552 0.9953217161457814 22.380989173568793 -10.185115739464893 4.589425789057547 1.0000051426457894 0.9717487636328517 0.32376167644633225 0.01924723513000074 1.0129696665927278e-06 1.7983594452832842e-07 0.018639447670727605 0.006212018426433623 6.52956516568385e-11 10.185115739464893 -0.02825637901293776 TIFPLFMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIFPLFMK 8 0 A0A087WUB9;Q8WYA6-3;Q8WYA6-2;Q8WYA6-4;Q8WYA6 A0A087WUB9 CTNNBL1 Beta-catenin-like protein 1 0 7579700.0 1924400.0 2371000.0 3284300.0 False True 2522907.03591611 2017256.0420856117 2944472.1412301864 1.0 0.7995760499170006 1.1670949818255982 21.26665561618782 -6.758631232579435 1.6177393885556757 0.8833840439923781 1.168342173168174 0.6853117181637106 0.084282776813409 0.2852221324160434 1.4708839992605391 0.04111383036184779 0.0989324083959664 1.7432865016976298e-07 6.758631232579435 0.2849581291757959 TIFPLFMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIFPLFMK 8 0 A0A087WUB9;Q8WYA6-3;Q8WYA6-2;Q8WYA6-4;Q8WYA6 A0A087WUB9 CTNNBL1 Beta-catenin-like protein 1 0 4581100.0 1611900.0 1159300.0 1809900.0 False True 1560731.1168094503 1622214.5356696346 1335832.8941638547 1.0 1.0393939854200336 0.8559020062947502 20.5737905801449 -6.850533297731599 1.2324290154239148 1.0210333205581426 0.8484876674324847 0.9410837740037273 0.01914404353862806 0.1568769554868229 0.4582444442742316 0.012152877597412775 0.028133688665480074 1.4108040647498257e-07 6.850533297731599 -0.17254565312565784 TIFPLFMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIFPLFMK 8 0 A0A087WUB9;Q8WYA6-3;Q8WYA6-2;Q8WYA6-4;Q8WYA6 A0A087WUB9 CTNNBL1 Beta-catenin-like protein 1 0 8299100.0 1924400.0 2423600.0 3951100.0 False True 2635902.6849545725 2316517.338226556 3017931.555458794 1.0 0.8788326486592122 1.1449328431906072 21.32986567771071 -6.782873816309431 1.5244000298656344 0.9316493993356619 1.1472446368969456 0.7775316018140047 0.05130743559212924 0.24612530652299724 1.1298113359145996 0.026503122520221772 0.062394916572042665 1.6486413325153074e-07 6.782873816309431 0.21559523756128363 TIFPLFMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIFPLFMK 8 0 A0A087WUB9;Q8WYA6-3;Q8WYA6-2;Q8WYA6-4;Q8WYA6 A0A087WUB9 CTNNBL1 Beta-catenin-like protein 1 0 5036800.0 1611900.0 1809300.0 1615600.0 False True 1340366.2692776378 1799552.9417820703 1953414.490309606 1.0 1.3425829812562364 1.4573736560547421 20.354195855579178 -12.4390355685738 0.17404130458986677 2.7226310896004443e-09 1.562460781177438 0.9994870718424539 0.004400216172729976 6.504378994795712 0.11877687298943918 2.372821653918341 0.08958454631035907 3.6388523282709365e-13 12.4390355685738 1.562460778454807 TIFQGIAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIFQGIAAK 9 0 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 46255800.0 8990800.0 19661000.0 17604000.0 False True 11787025.867031058 16727655.437977746 15782506.949491914 1.0 1.4191582869743158 1.3389727932672508 23.490696403888972 -10.072427693049748 4.87072461572042 0.9999884982348738 1.3790655401243925 0.9675295346937222 0.03273559073836751 4.088789540141372e-06 7.786103277544429e-07 0.03169706053888547 0.010565366478055132 8.463934755861285e-11 10.072427693049748 0.37907704188951874 TIFQGIAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIFQGIAAK 9 0 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 27126100.0 8868300.0 6430800.0 11827000.0 False True 8586780.670761984 8998651.976178968 8729153.89760534 1.0 1.0479657419013166 1.016580512802445 23.03368591129669 -10.219920188254497 3.837050919680056 0.9999674457568112 1.0322731273634587 0.5850348658633392 0.012812966166122404 1112054.0178252712 2971401.7495449414 147.12011993839639 0.004386219308841467 6.026703306349302e-11 10.219920188254497 0.032305681606647485 TIFQGIAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIFQGIAAK 9 0 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 116937000.0 25375000.0 70165000.0 21397000.0 False True 38495730.16098888 57643507.548352815 17167873.571361758 1.0 1.4974000313096558 0.4459682541301549 25.198195099183145 -6.778071522600396 1.5435347369748216 1.2823419147919868 0.4381538289049556 0.7604815598947705 0.21017682877598134 0.2535672305200004 1.1931490959486084 0.10726595033803367 0.25349784532858327 1.666972661428408e-07 6.778071522600396 -0.8441880858870312 down TIFQGIAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIFQGIAAK 9 0 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 35711800.0 8990800.0 13794000.0 12927000.0 False True 12314941.727234244 13184535.469341949 9873908.839922003 1.0 1.0706128994654205 0.8017828308587165 23.553906465411863 -6.836886766371905 1.2966511838069428 1.0375940982194432 0.7934654668169936 0.9189854436728254 0.032389828165162275 0.17246874455666542 0.5645947867118447 0.019596017689527498 0.045117815311204186 1.4558386119967818e-07 6.836886766371905 -0.24412863140244956 TIFQGIAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIFQGIAAK 9 0 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 21317500.0 8868300.0 8003300.0 4445900.0 False True 7374384.382303412 7960184.634369338 5375517.134480982 1.0 1.0794371735587438 0.7289445268652951 22.814091186730966 -6.847152347949128 1.2488286317865804 1.0423075738316105 0.7156899719229565 0.9360471919705229 0.037945178090985854 0.16061834252753654 0.48348694303070977 0.023792962534888634 0.0549650368132678 1.4218299300555905e-07 6.847152347949128 -0.3266176019086541 TIFQGIAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIFQGIAAK 9 0 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 0 41883000.0 25375000.0 0.0 16508000.0 False True 32848437.71602915 0.0 13503713.386383886 1.0 0.0 0.4110914955262679 24.969321421275595 -10.726801676011137 6.7101362693412465 1.0116646284898476 0.2055457477631403 0.8327663627257647 0.16782740027283166 0.028780428773860493 0.0011717729054834466 0.15969039750345151 0.054166060524496906 1.875850934579687e-11 10.726801676011137 -0.8061188807267073 TIFTGHTAVVEDVSWHLLHESLFGSVADDQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIFTGHTAVVEDVSWHLLHESLFGSVADDQK 31 0 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 59821000.0 14328000.0 22834000.0 22659000.0 False True 21736623.517109312 18759094.297143713 18180438.71820748 1.0 0.8630178593459131 0.8363966328025743 24.373624519321844 -13.999999999690019 0.2303224755325094 1.8660202417013165 0.8234928142838884 0.9995102298039898 0.0015862644745580088 13.301377694795711 0.15195522871929737 5.2688600258529625 0.013791180651741553 1.0000000007137585e-14 13.999999999690019 -1.042527427417428 TIFTGHTAVVEDVSWHLLHESLFGSVADDQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIFTGHTAVVEDVSWHLLHESLFGSVADDQK 31 0 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 0 32300200.0 14328000.0 7524200.0 10448000.0 False True 18547878.44710407 7105471.655696629 8546571.205533 1.0 0.38308810767551826 0.4607843010135425 24.144750841414293 -10.583773040234865 6.4437696732210545 1.001202001776938 0.42193620434548096 0.9866320613343506 0.03171933810579818 0.0005486995200401817 3.54424843284185e-05 0.03076615897686744 0.010237372353039885 2.6075158665935768e-11 10.583773040234865 -0.5792657974314571 TIGGGDDSFNTFFSETGAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIGGGDDSFNTFFSETGAGK 20 0 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8W0F6;F8VRK0;F8VXZ7;P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 273784000.0 41454000.0 118060000.0 114270000.0 False True 54346595.44110702 100445908.1942755 102446436.55523959 1.0 1.848246562254746 1.8850571176304176 25.695686324228117 -11.1012267445275 0.5382974430638875 1.1563912803049896e-08 1.882213114966613 0.9998628778059698 0.004787244202630456 3.091609447215395 0.2633351769450482 3.7782429958546153 0.007002652897677925 7.920876746638972e-12 11.1012267445275 1.8822131034027003 TIGGGDDSFNTFFSETGAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIGGGDDSFNTFFSETGAGK 20 0 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8W0F6;F8VRK0;F8VXZ7;P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 301839000.0 80088000.0 47041000.0 174710000.0 False True 77545650.27795486 65824716.61557421 128948209.81234725 1.0 0.848851178365671 1.662868379466094 26.208542523507468 -6.858757409632333 1.1921519210354996 0.9182545770274853 1.7013297206508757 0.9520870444197993 0.07738473905431885 0.1480972779105471 0.4006842811480121 0.05065499901042074 0.11807150137704185 1.3843394342366e-07 6.858757409632333 0.7830751436233905 TIGGGDDSFNTFFSETGAGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIGGGDDSFNTFFSETGAGK 20 0 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8W0F6;F8VRK0;F8VXZ7;P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 684643000.0 79180000.0 533500000.0 71963000.0 False True 120121848.83338337 438292756.7454741 57739481.507496566 1.0 3.6487346890024477 0.4806742659079856 26.839923344253343 -6.684872957486651 1.8844548452911694 2.6684898622884994 0.49219960171714267 0.34660147627709115 1.1214195150047404 0.4277958053027963 2.941169607699938 0.4767700272059739 1.2497080797814528 2.0659844219912566e-07 6.684872957486651 -2.1762902605713568 TIGGGDDSFNTFFSETGAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIGGGDDSFNTFFSETGAGK 20 0 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8W0F6;F8VRK0;F8VXZ7;P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 266888800.0 41454000.0 105674800.0 119760000.0 False True 56780664.05222759 101005737.91616754 91475154.53462204 1.0 1.7788756014417366 1.6110265010370788 25.758896385751008 -10.043441446997187 4.490502837822154 0.9999664203670946 1.6949510510620194 0.9580826472959239 0.06852410849162914 47806554.47154995 85498768.63489409 23877.019476009467 0.025077254063879003 9.048124192853542e-11 10.043441446997187 0.6949846306949248 TIGGGDDSFNTFFSETGAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIGGGDDSFNTFFSETGAGK 20 0 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8W0F6;F8VRK0;F8VXZ7;P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 189385000.0 80088000.0 52456000.0 56841000.0 False True 66596720.4999737 52173409.11629929 68726190.29691021 1.0 0.7834230983839495 1.0319755955090515 25.988947798941744 -6.676398821547042 1.9143641805481473 0.8625247479127892 1.0310095119609162 0.3076805878981983 0.0918645298123287 0.446682271741344 3.161662657554879 0.03854672278325551 0.10214772450552716 2.1066926422173152e-07 6.676398821547042 0.16848476404812696 TIGGGDDSFNTFFSETGAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIGGGDDSFNTFFSETGAGK 20 0 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8W0F6;F8VRK0;F8VXZ7;P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 245658000.0 79180000.0 88644000.0 77834000.0 False True 102500070.87114054 83710883.47566156 63669010.644281685 1.0 0.8166909814228316 0.6211606499699314 26.611049666345792 -6.970305340491699 0.25078445363790597 1.061456418765948 0.3706626572708918 0.9999846663382383 0.000605700572514893 0.07620372573682319 0.008674850982986993 0.004337973874840373 0.0187157988083926 1.0707662142887195e-07 6.970305340491699 -0.6907937614950563 TIGGGDDSFNTFFSETGAGK(ub)HVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIGGGDDSFNTFFSETGAGKHVPR 24 1 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8W0F6;F8VRK0;P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 824080000.0 333890000.0 295360000.0 194830000.0 True False 437733023.3953599 251293439.30426246 174670860.5413262 1.0 0.5740792352266614 0.39903514518154987 28.705475986785128 -13.999999999999952 0.12219665843020867 3.027168624150439 0.12774762806226908 0.9996822347331475 0.004498705913321465 11.955853909726075 0.10785945368089868 5.869314859585642 0.24078918415835646 1.0000000000001104e-14 13.999999999999952 -2.89942099608817 TIGGGDDSFNTFFSETGAGK(ub)HVPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIGGGDDSFNTFFSETGAGKHVPR 24 1 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8W0F6;F8VRK0;P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 920042000.0 305050000.0 312422000.0 302570000.0 True False 295366354.72592753 437173733.85920686 223317840.09456736 1.0 1.4801067449434562 0.7560706780627926 28.137930256716345 -6.727949733733016 1.7310367892242489 1.289588414663929 0.7566857064614873 0.549605389092741 0.20185963407116037 0.34008593062355164 1.9955447913489435 0.09245327531306637 0.2299219975270072 1.8708986700565803e-07 6.727949733733016 -0.5329027082024417 TIGGGDDSFNTFFSETGAGK(ub)HVPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIGGGDDSFNTFFSETGAGKHVPR 24 1 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8W0F6;F8VRK0;P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 2928150000.0 928200000.0 641570000.0 1358380000.0 True False 1408147260.5095518 527076820.8907103 1089895597.6008952 1.0 0.3743051850272978 0.7739926271677764 30.3911510692808 -9.929401691040882 5.476420299190972 1.0000005837292498 0.5741489060963002 0.6021654096702632 0.16317171497844482 1.1629679696093435e-06 2.2741060915235966e-07 0.15799055025017977 0.052663444556284196 1.1765172765758953e-10 9.929401691040882 -0.4258516776329496 TIGGGDDSFNTFFSETGAGK(ub)HVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIGGGDDSFNTFFSETGAGKHVPR 24 1 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8W0F6;F8VRK0;P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 822390000.0 333890000.0 281950000.0 206550000.0 True False 457338156.037977 269492516.7160331 157767144.03078002 1.0 0.5892631374795123 0.34496825149590005 28.76868604830802 -8.909990633911216 0.1696563069511935 1.4414666023723164 1.2252612259117933e-10 0.9997762423809136 0.004042956144838075 0.4004465852523489 0.052787354223088015 0.24668829921162294 0.15395628461119823 1.2302953033410432e-09 8.909990633911216 -1.4414666022497902 TIGGGDDSFNTFFSETGAGK(ub)HVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIGGGDDSFNTFFSETGAGKHVPR 24 1 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8W0F6;F8VRK0;P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 1015854000.0 305050000.0 411461000.0 299343000.0 True False 253662591.00635475 409244377.92438626 361934237.2943475 1.0 1.6133414718378158 1.426833321612174 27.91833553215062 -10.157328420328907 4.560464259694569 0.9999264423066389 1.5200873967330037 0.9120339221672595 0.07614163352067331 53301995.58902344 5.991582743081283 41789.75258589663 0.026065306397825002 6.960999133034463e-11 10.157328420328907 0.5201609544263649 TIGGGDDSFNTFFSETGAGK(ub)HVPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIGGGDDSFNTFFSETGAGKHVPR 24 1 F8VVB9;F8VS66;F8VRZ4;F8VX09;F8VWV9;F8W0F6;F8VRK0;P68363;P68363-2;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;F8VQQ4;Q9BQE3;F5H5D3;A0A1W2PQM2 F8VVB9;P68363;Q71U36;Q9BQE3 TUBA1B;TUBA1C;TUBA1A;TUBA3E Tubulin alpha-1B chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 2992985000.0 928200000.0 601115000.0 1463670000.0 True False 1201573197.5573697 567662421.8274481 1197297078.5224428 1.0 0.47243265993401523 0.9964412330071779 30.162277391373248 -10.886195321851464 10.918748094807857 1.0151901814833373 0.7344369464723388 0.25509333823559754 0.21392560414552692 0.07299530789364536 0.0007608191411081222 0.19113604039277823 0.06904419184858213 1.2995849645012302e-11 10.886195321851464 -0.28075323501099847 TIGGGDDSFTTFFCETGAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIGGGDDSFTTFFCETGAGK 20 0 P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2 P68366-2 TUBA4A Tubulin alpha-4A chain 0 4404890.0 829190.0 2322300.0 1253400.0 False True 1087076.1198873837 1975821.8922544983 1123710.1914617787 1.0 1.8175561546317334 1.0336996378673007 20.052021534472367 -10.18926973800013 3.950880195792304 0.999756990248559 1.4256278956619357 0.2821870322843766 0.32000808361823113 226498592.99984083 523275600.77962047 807376.3265073901 0.11711093957025252 6.467408036956036e-11 10.18926973800013 0.4258709054133767 TIGGGDDSFTTFFCETGAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIGGGDDSFTTFFCETGAGK 20 0 P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2 P68366-2 TUBA4A Tubulin alpha-4A chain 0 4248890.0 829190.0 1099900.0 2319800.0 False True 1135763.951017192 1051302.7811170944 1771911.017780696 1.0 0.9256349263203378 1.560104999101063 20.115231595995258 -6.877678430340068 1.092615505993639 0.9551787910420066 1.6031233523988644 0.9717662909358056 0.04758511934868558 0.1297087693651616 0.2848541617203445 0.03361470452350811 0.08083388827487444 1.3253224957616816e-07 6.877678430340068 0.6479445613568577 TIGGGDDSFTTFFCETGAGK(ub)HVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIGGGDDSFTTFFCETGAGKHVPR 24 1 P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2 P68366-2 TUBA4A Tubulin alpha-4A chain 1 13247200.0 4602800.0 5639200.0 3005200.0 True False 6034315.373578609 4797853.341429439 2694250.7319139456 1.0 0.7950948938527397 0.4464882203059498 22.52475866786515 -6.963080752287913 0.3895978243762478 1.021506330552756 0.20755922539769858 0.9998679396999047 0.0026257961982741555 0.07861851408059473 0.01719554050643271 0.004501938506149616 0.029329161943977146 1.0887276375679544e-07 6.963080752287913 -0.8139471051550575 down TIGGGDDSFTTFFCETGAGK(ub)HVPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIGGGDDSFTTFFCETGAGKHVPR 24 1 P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2 P68366-2 TUBA4A Tubulin alpha-4A chain 1 48599000.0 12383000.0 12084000.0 24132000.0 True False 18785916.31856258 9927515.787277073 19362299.622568656 1.0 0.5284552331081972 1.0306816710045996 24.163148152083945 -10.142600642443098 14.761417420840898 0.9999931551246658 0.779568452055186 0.20436292378148768 0.20503308473504692 0.0 0.0 0.19852243063288402 0.06617414354429466 7.201108550034885e-11 10.142600642443098 -0.2204247030694798 TIGGGDDSFTTFFCETGAGK(ub)HVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIGGGDDSFTTFFCETGAGKHVPR 24 1 P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2 P68366-2 TUBA4A Tubulin alpha-4A chain 1 14284400.0 4602800.0 5041100.0 4640500.0 True False 6304579.54599299 4818367.533311553 3544509.474097478 1.0 0.7642646901606578 0.5622118728520551 22.58796872938804 -6.972919430151883 0.17491149900960606 1.1671381611607095 0.15390179528037962 0.9999971138432101 0.00030387710757552876 0.0753662473734896 0.005485024974704794 0.0081426509358607 0.02303700311506227 1.0643404552133043e-07 6.972919430151883 -1.0132363658803298 TIGGGDDSFTTFFCETGAGK(ub)HVPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIGGGDDSFTTFFCETGAGKHVPR 24 1 P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2 P68366-2 TUBA4A Tubulin alpha-4A chain 1 9923100.0 3587800.0 2638600.0 3696700.0 True False 2983414.666489429 2624385.338078909 4469662.878390388 1.0 0.8796582545352343 1.4981701768094546 21.508533081932374 -6.856229145372333 1.2045620305618956 0.9352511969286771 1.526045811124138 0.9488969043814988 0.060527646493308954 0.15073967407047234 0.41776038186403514 0.039245742830205314 0.09126138934909254 1.3924219300793898e-07 6.856229145372333 0.5907946141954609 TIGGGDDSFTTFFCETGAGK(ub)HVPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIGGGDDSFTTFFCETGAGKHVPR 24 1 P68366-2;P68366;C9JEV8;C9JQ00;C9JJQ8;C9JDL2 P68366-2 TUBA4A Tubulin alpha-4A chain 1 48525000.0 12383000.0 10942000.0 25200000.0 True False 16030037.605422229 10333068.08120897 20613858.57383535 1.0 0.6446066026516224 1.2859519784821107 23.934274474176394 -6.756256288242025 1.6262933043310452 0.7926156010515872 1.287894593588516 0.6756328167442591 0.14941070353033342 0.2892382985405952 1.5067613728061828 0.0725151138990181 0.17493417223584615 1.752845797591634e-07 6.756256288242025 0.49527899253692875 TIGISVDPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIGISVDPR 9 0 P26373;J3QSB4 P26373 RPL13 60S ribosomal protein L13 0 113704000.0 46398000.0 26082000.0 41224000.0 False True 60828227.31887122 22190667.26683969 36958535.928530656 1.0 0.3648087120887592 0.6075885745410292 25.85823762542395 -10.26114405412405 5.589950369256636 1.0000380738837205 0.486198643314918 0.8565646377216042 0.09911446380523913 4.7033347941198336e-05 6.21658314849724e-06 0.09597425525556837 0.03198905564049043 5.4809513332112233e-11 10.26114405412405 -0.5138394305688024 TIGISVDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIGISVDPR 9 0 P26373;J3QSB4 P26373 RPL13 60S ribosomal protein L13 0 144561000.0 30218000.0 86000000.0 28343000.0 False True 45842915.23171486 70652628.0789332 22740993.626821775 1.0 1.5411896848578814 0.4960634268539971 25.450195454741966 -6.765947562907164 1.5898389757500135 1.312005838100765 0.4910437701036778 0.714907724973536 0.22786509499949106 0.27301207138260825 1.3611820702072288 0.1130141273795633 0.2700468839962617 1.714164264695779e-07 6.765947562907164 -0.8209620679970873 down TIGISVDPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIGISVDPR 9 0 P26373;J3QSB4 P26373 RPL13 60S ribosomal protein L13 0 121895000.0 46398000.0 37384000.0 38113000.0 False True 63552594.45880398 35732251.267643854 29111494.361874186 1.0 0.5622469321973345 0.4580693299743226 25.92144768694684 -13.999999999999998 0.20165885377115603 3.448913684101352 0.3915068287435374 0.999487075838178 0.005317654685023246 12.56422258595566 0.14238417729384026 12.144655584416041 0.06552378905922708 1.0000000000000041e-14 13.999999999999998 -3.0574068553578146 TIGISVDPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIGISVDPR 9 0 P26373;J3QSB4 P26373 RPL13 60S ribosomal protein L13 0 47212000.0 20115000.0 16021000.0 11076000.0 False True 16726513.745591966 15934691.693080474 13391940.390362214 1.0 0.9526606641075959 0.800641460261943 23.99563344455126 -6.9499117907774135 0.5598145768374494 1.0019901386407248 0.7440491011281832 0.9991943147460045 0.0024139760369792447 0.08352125176528008 0.036109604383404395 0.002588224323940543 0.012636397420590483 1.1222463697636807e-07 6.9499117907774135 -0.2579410375125416 TIGISVDPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIGISVDPR 9 0 P26373;J3QSB4 P26373 RPL13 60S ribosomal protein L13 0 105504000.0 30218000.0 47397000.0 27889000.0 False True 39117796.685831375 44759315.28468848 22813488.16530531 1.0 1.1442187208079766 0.5831997223291578 25.221321776834415 -6.838488151590359 1.2893759941933647 1.076742816850834 0.5652901099870755 0.9218286070790029 0.06650802999762259 0.17057041463582226 0.5514900954833256 0.040456350351771926 0.0931704124567883 1.4504803457285307e-07 6.838488151590359 -0.5114527068637584 TIGTGLVTNTLAMTEEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIGTGLVTNTLAMTEEEK 18 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 23538000.0 5916900.0 7379100.0 10242000.0 False True 7757113.199341109 6278167.043506511 9182256.08820133 1.0 0.8093432288753734 1.1837207801713234 22.887088424332426 -6.768248882481962 1.580977854116869 0.8904001935052628 1.1856972832190968 0.7238774161502306 0.08031746279750808 0.2692732896644225 1.3279829093082074 0.0400486006531594 0.09549318577201477 1.705104959187875e-07 6.768248882481962 0.29529708971383406 TIGTGLVTNTLAMTEEEK ddPTM_RPMI8226_Bortezomib_2h_R1 2 TIGTGLVTNTLAMTEEEK 18 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 39011300.0 9951500.0 7999800.0 21060000.0 False True 9635595.07967569 11194161.858405877 15543754.213542623 1.0 1.161750962534495 1.613159756612125 23.19994233724487 -6.9530638859235525 0.5241310677337099 0.992567022627563 1.8026311609661665 0.9994202990719404 0.006247127571540056 0.08227831232546694 0.03104772867312069 0.007031548496822973 0.037302743720926394 1.1141306298290662e-07 6.9530638859235525 0.8100641383386035 TIGTGLVTNTLAMTEEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIGTGLVTNTLAMTEEEK 18 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 26627000.0 5916900.0 9306100.0 11404000.0 False True 8104537.8282102 8894925.730842615 8710610.072752422 1.0 1.0975241178937112 1.0747818391855253 22.950298485855317 -10.049483244106389 4.246341629432108 0.9999921938093839 1.0861529785614983 0.950333360650157 0.00928449647385839 6430487.134836819 0.13313471871387758 498.3348974287116 0.0031783300858285665 8.923120459918205e-11 10.049483244106389 0.08616078475211442 TIGTGLVTNTLAMTEEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIGTGLVTNTLAMTEEEK 18 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 16319400.0 7976800.0 4226800.0 4115800.0 False True 6633062.6321570035 4204029.389445893 4976394.750690926 1.0 0.6337991396409874 0.7502408806703298 22.66124371779493 -10.73223197176391 10.071721345334105 1.0006189243008365 0.6920200101556588 0.9031713649794526 0.04753714171386487 0.0006618489961298473 1.759596968058739e-05 0.04611064194848413 0.0153425465153417 1.8525418521689197e-11 10.73223197176391 -0.3085989141451777 TIHGLIYNALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIHGLIYNALK 11 0 E9PFR3;Q14738-3;Q14738-2;Q14738;H0Y8C4;H7C5Q9;H0YJ49;H0YJ75;Q13362-2;Q13362-3;Q13362;Q13362-4;Q13362-5;H0YN84 E9PFR3;H0YJ75 PPP2R5D;PPP2R5C Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform;Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform 0 14266400.0 4730600.0 4758800.0 4777000.0 False True 6201862.411195568 4048805.589657116 4282721.864219656 1.0 0.652837054615761 0.6905541561980657 22.564270089327003 -10.005374880700254 7.253563226162186 1.0000000200308832 0.6716956056706196 0.990198180983922 0.015397942242228112 4.984842806631474e-09 6.738135950422638e-10 0.01490899435614673 0.0049696644891677084 9.877001490350812e-11 10.005374880700254 -0.3283044143602636 TIHGLIYNALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIHGLIYNALK 11 0 E9PFR3;Q14738-3;Q14738-2;Q14738;H0Y8C4;H7C5Q9;H0YJ49;H0YJ75;Q13362-2;Q13362-3;Q13362;Q13362-4;Q13362-5;H0YN84 E9PFR3;H0YJ75 PPP2R5D;PPP2R5C Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform;Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform 0 20259200.0 8011400.0 3938300.0 8309500.0 False True 7757082.492218647 5510883.727963182 6132992.670343425 1.0 0.7104325284011493 0.7906313586964695 22.887082713303098 -9.978660787702877 6.592458257356259 1.0000000461188872 0.750531943548807 0.9280641384560029 0.03274103536527512 2.2202348218223567e-08 3.439475155796637e-09 0.03170137731783979 0.010567123725606864 1.0503625099236985e-10 9.978660787702877 -0.24946810257008012 TIHGLIYNALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIHGLIYNALK 11 0 E9PFR3;Q14738-3;Q14738-2;Q14738;H0Y8C4;H7C5Q9;H0YJ49;H0YJ75;Q13362-2;Q13362-3;Q13362;Q13362-4;Q13362-5;H0YN84 E9PFR3;H0YJ75 PPP2R5D;PPP2R5C Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform;Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform 0 18735300.0 4730600.0 5076700.0 8928000.0 False True 6479630.659658128 4852394.607598095 6819390.277931746 1.0 0.748869011594885 1.0524350284945938 22.627480150849895 -6.6869737384669685 1.876783083730725 0.8421185830153806 1.0513611692028555 0.3565105963151768 0.106275886497832 0.42318458366500206 2.8874635907068305 0.04533701325110935 0.11852991039831942 2.05601491824352e-07 6.6869737384669685 0.20924258618747493 TIHGLIYNALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIHGLIYNALK 11 0 E9PFR3;Q14738-3;Q14738-2;Q14738;H0Y8C4;H7C5Q9;H0YJ49;H0YJ75;Q13362-2;Q13362-3;Q13362;Q13362-4;Q13362-5;H0YN84 E9PFR3;H0YJ75 PPP2R5D;PPP2R5C Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform;Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform 0 15269200.0 8011400.0 4197300.0 3060500.0 False True 6661834.065196894 4174688.311801182 3700436.39984683 1.0 0.6266575046668919 0.5554681133801944 22.667487988737374 -13.999999999999998 0.23301502211238317 3.3901631393769676 0.5218334365783099 0.9995140559010777 0.004297574196191831 13.38701156695443 0.15282093960243168 14.828990619808186 0.03627278398905704 1.0000000000000041e-14 13.999999999999998 -2.8683297027986576 TIHLSSIRPPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIHLSSIRPPR 11 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 TIHLSSIRPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIHLSSIRPPR 11 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 3449700.0 1591600.0 1858100.0 0.0 False True 2180057.531372736 1776002.9980849817 0.0 1.0 0.8146587750675873 0.0 21.055934777322225 -7.228321049686697 0.8695504757181581 0.9897537960806144 4.0566642628216245e-16 0.9890579792039944 0.04543588036701161 0.09595895510229183 0.13896428154088883 0.03840764574083879 0.06752420524375873 5.9112448725411553e-08 7.228321049686697 -0.989753796080614 down TIHLSSIRPPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIHLSSIRPPR 11 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 2542400.0 0.0 2542400.0 0.0 False True 0.0 2400913.2050507837 0.0 0.0 TIHQLVLEHFLTFLPKPSLVQPSQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIHQLVLEHFLTFLPKPSLVQPSQK 25 1 P98182-3;P98182-2;P98182 P98182-3 ZNF200 Zinc finger protein 200 0 47178500.0 8158800.0 11306700.0 27713000.0 False True 12377496.088176424 9288931.045349685 22235513.40296058 1.0 0.7504693177986876 1.796446813196815 23.561216157557713 -6.843766732018495 1.2649020611171526 0.8672548034765971 1.8334700625197458 0.9307191131640361 0.11740653573160899 0.1644477124135765 0.5094807245383509 0.07273516042565135 0.1677650544488359 1.432957361773695e-07 6.843766732018495 0.9662152590431486 TIHQLVLEHFLTFLPKPSLVQPSQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIHQLVLEHFLTFLPKPSLVQPSQK 25 1 P98182-3;P98182-2;P98182 P98182-3 ZNF200 Zinc finger protein 200 0 27548900.0 8158800.0 3168300.0 16221800.0 False True 10561727.433991693 2991981.3198404657 13269598.849723872 1.0 0.28328522379881926 1.256385277186496 23.332342479650162 -6.709357654428654 1.797201490814495 0.55907656891412 1.2540770022657675 0.46202828745411484 0.30205338645294166 0.3764500173742879 2.3697426259995176 0.1337579885548685 0.3401103819922142 1.952730661616362e-07 6.709357654428654 0.6950004333516474 TIHWIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIHWIK 6 0 P78406;E9PQ57;E9PPG9;B0QZ36 P78406 RAE1 mRNA export factor 0 6183900.0 1664800.0 2423300.0 2095800.0 False True 2182568.9219461316 2061753.0859494156 1878946.7203331722 1.0 0.9446451221851963 0.8608876913072562 21.05759578184093 -6.965112508281338 0.3561195349072725 1.0075449893951727 0.7951347861974382 0.9999154318385619 0.0005258522324916228 0.07792282942430868 0.01472566916766596 0.0011330442651072423 0.007170907096233188 1.0836461484016454e-07 6.965112508281338 -0.21241020319773452 TIHWIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIHWIK 6 0 P78406;E9PQ57;E9PPG9;B0QZ36 P78406 RAE1 mRNA export factor 0 7291200.0 2894200.0 1433300.0 2963700.0 False True 2802325.2052049823 2005624.16456076 2187418.0609058077 1.0 0.7157000054224806 0.7805725248600489 21.41819295718146 -10.122759904835329 7.188040424414054 1.0000001246028978 0.7481362651412652 0.9526016873010952 0.02648409515847104 5.2884758841369753e-08 6.432298483710887e-09 0.025643127863741778 0.008547704957344228 7.53772163628194e-11 10.122759904835329 -0.2518638594616326 TIHWIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIHWIK 6 0 P78406;E9PQ57;E9PPG9;B0QZ36 P78406 RAE1 mRNA export factor 0 5515200.0 1664800.0 1995700.0 1854700.0 False True 2280321.549528356 1907523.3751026334 1416658.0587455228 1.0 0.8365150851191011 0.6212536381277163 21.120805843363822 -6.96733248531741 0.3154658310351893 1.0310933807615656 0.41977820584738856 0.9999534673228054 0.001058020066482162 0.07717811233644535 0.012114006326024477 0.003325059474973129 0.01901259965765394 1.0781210229073958e-07 6.96733248531741 -0.6113151749141771 TIIFSIHQPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIIFSIHQPR 10 0 Q9UNQ0-2;Q9UNQ0 Q9UNQ0-2 ABCG2 ATP-binding cassette sub-family G member 2 0 5945700.0 1820300.0 1852700.0 2272700.0 False True 2386430.9278102736 1576284.3817680357 2037542.8052777941 1.0 0.6605195915787065 0.8538033854377634 21.186423149356575 -10.173869463841203 5.260005851657735 1.000010961402058 0.7571614885081307 0.6779040555503721 0.07890777841769415 1.0143637192754909e-05 1.5931488446313237e-06 0.07640557512812146 0.025467375974776992 6.700859873070688e-11 10.173869463841203 -0.24284947289392733 TIIFSIHQPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIIFSIHQPR 10 0 Q9UNQ0-2;Q9UNQ0 Q9UNQ0-2 ABCG2 ATP-binding cassette sub-family G member 2 0 5460500.0 1820300.0 1539000.0 2101200.0 False True 2493314.1017578486 1471001.8912075723 1604939.8355723761 1.0 0.5899785711597585 0.6436974123881357 21.249633210879466 -10.13694411350145 5.172849978674716 1.0000130597159032 0.6168379917746882 0.9854723909104179 0.02193062509862768 3.3259884355653438e-06 5.54926905879876e-07 0.021234964628780915 0.0070780788147006635 7.295513853805671e-11 10.13694411350145 -0.3831750679412149 TIIFVETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIIFVETK 8 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 37266000.0 10492000.0 11555000.0 15219000.0 False True 13755113.604672518 9831039.041037213 13644283.870956447 1.0 0.7147188546445503 0.9919426522454585 23.713464719257942 -10.7322467940265 9.266426480383885 1.0004844217818771 0.8533307534982413 0.2717804322586036 0.11317614144647074 0.0011362626221714898 3.283226221411216e-05 0.10993256902213294 0.036527442584183 1.8524786268820226e-11 10.7322467940265 -0.14715366828363585 TIIFVETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIIFVETK 8 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 30115200.0 8998000.0 9001200.0 12116000.0 False True 8712363.415256193 12595426.1006379 8942456.127791192 1.0 1.4456956741017124 1.0264099075725062 23.05463270318304 -10.454621280483332 3.1860531173099975 0.9956974575551083 1.2360527906705308 0.29706520540985937 0.1711726991452895 61706162.38929155 86211559.9412737 2420455.2646641824 0.06042390518150591 3.510578748840838e-11 10.454621280483332 0.24035533311542245 TIIFVETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIIFVETK 8 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 51386000.0 12722000.0 25870000.0 12794000.0 False True 19300204.102782317 21253296.376767445 10265260.292190583 1.0 1.1011954207107877 0.5318731469119927 24.202112768519136 -6.8609715689425785 1.180909265093902 1.0550463060294581 0.5037998057511622 0.954805530625706 0.05272111200323752 0.14579851720895443 0.3858154034623264 0.034808330171898265 0.08133885776933773 1.3772996307652294e-07 6.8609715689425785 -0.5512465002782959 TIIFVETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIIFVETK 8 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 33732000.0 10492000.0 10441000.0 12799000.0 False True 14371175.935638819 9979682.096230187 9776139.803679265 1.0 0.6944234863538031 0.680260254794849 23.776674780780834 TIIFVETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIIFVETK 8 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 19012400.0 8998000.0 6247600.0 3766800.0 False True 7482235.678987656 6213942.938748498 4554420.464284613 1.0 0.830492810617968 0.6086978090084466 22.835037978617315 -6.967427815864777 0.3136010820420274 1.0327483593251094 0.3993550879617253 0.9999547999371654 0.001077180646872242 0.07714648420970563 0.012003336413709004 0.003453626128615436 0.01962367218042323 1.0778843940941498e-07 6.967427815864777 -0.6333932713633841 TIIFVETK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIIFVETK 8 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 39922000.0 12722000.0 14619000.0 12581000.0 False True 16468879.788111271 13805439.798866184 10291387.091961186 1.0 0.8382743681711856 0.6248990352938542 23.973239090611585 -6.967301717759783 0.3160652114172627 1.0306043474931157 0.42572635867655495 0.9999530322445306 0.001052771170754134 0.07718834813327784 0.012149743435991687 0.0032875369527237135 0.018835631943068844 1.0781974050101278e-07 6.967301717759783 -0.6048779888165607 TIIGSFNGALAAVPVQDLGSTVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIIGSFNGALAAVPVQDLGSTVIK 24 0 Q9BWD1 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 14920100.0 8598100.0 0.0 6322000.0 False True 13043946.305308333 0.0 5072453.928968969 1.0 0.0 0.3888741804238105 23.636877071647532 -10.677022720542977 6.638488863231361 1.0057812052607813 0.19443709021191433 0.8512264670808524 0.15875721936355647 0.013575114920152606 0.0006604586317993967 0.15361714273456878 0.05123867222377098 2.1036683814071283e-11 10.677022720542977 -0.8113441150488669 TIIGSFNGALAAVPVQDLGSTVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIIGSFNGALAAVPVQDLGSTVIK 24 0 Q9BWD1 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 22903500.0 8598100.0 7317500.0 6987900.0 False True 11130409.943889285 6910274.692400534 5716173.90190889 1.0 0.6208463773784315 0.513563645070156 23.408003393739982 -13.999999999999998 0.17708199628109983 2.950105438511991 0.4257259764054507 0.99950194862262 0.004656891551849099 12.168350231165315 0.13336958509490107 8.159589848943414 0.08213255776109378 1.0000000000000041e-14 13.999999999999998 -2.5243794621065403 TIIITCSFTPGSCTLTAYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIIITCSFTPGSCTLTAYK 19 0 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 37701000.0 10370000.0 11554000.0 15777000.0 False True 15732048.14854995 9492098.428185957 12658669.03469525 1.0 0.6033606265730161 0.8046421492717096 23.90720317103647 -10.26930345106174 4.7470069203373955 1.000100615400745 0.7040013879217996 0.7424960557539118 0.08217283754574642 8.753161412236047e-05 1.347355487828688e-05 0.0795904547996947 0.02652116927681736 5.378938130002262e-11 10.26930345106174 -0.29609922747894546 TIIITCSFTPGSCTLTAYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIIITCSFTPGSCTLTAYK 19 0 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 27736100.0 10370000.0 8991100.0 8375000.0 False True 13424169.423260001 8490737.381187888 6850835.934756786 1.0 0.6324962918358303 0.5103359261010496 23.67832949312892 -13.999999999999998 0.1539003838559041 2.788555492699224 0.3817808228390792 0.9995537468564872 0.0043960615899752515 11.974556542672564 0.12373847459338896 6.398533547562354 0.11633547381155018 1.0000000000000041e-14 13.999999999999998 -2.406774669860145 TIIMWK(ub)LTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIIMWKLTR 9 1 P63244;D6RAC2;D6REE5;D6RHH4;D6R9L0;D6R9Z1;D6RBD0;D6RFZ9;E9PD14;D6RAU2;D6RGK8;D6R909 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 87155300.0 39166000.0 25809000.0 22180300.0 True False 37922696.76838453 36114668.29215702 16370614.03526302 1.0 0.9523233147877069 0.4316838049584835 25.176558225389595 -6.924799597078162 0.788307244754004 1.0096251535524916 0.33769896584993075 0.9954137335864323 0.01743206060866955 0.09542938513208853 0.09157700989127905 0.015414891630657351 0.048525391796094615 1.1890507821405009e-07 6.924799597078162 -0.6719261877025609 down TIIMWK(ub)LTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIIMWKLTR 9 1 P63244;D6RAC2;D6REE5;D6RHH4;D6R9L0;D6R9Z1;D6RBD0;D6RFZ9;E9PD14;D6RAU2;D6RGK8;D6R909 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 46751400.0 12373800.0 17108300.0 17269300.0 True False 16948728.249371715 16352398.73641749 13190647.012397699 1.0 0.9648156779564666 0.7782676563291215 24.014673688773257 -6.938505747731576 0.6733210458409558 1.002157915731717 0.7300984401218242 0.9979615570829337 0.0043929467650048355 0.0884550082856198 0.05776384810055627 0.00422925776244956 0.016164382998143146 1.1521108119518657e-07 6.938505747731576 -0.27205947560989285 TIIMWK(ub)LTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIIMWKLTR 9 1 P63244;D6RAC2;D6REE5;D6RHH4;D6R9L0;D6R9Z1;D6RBD0;D6RFZ9;E9PD14;D6RAU2;D6RGK8;D6R909 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 74201800.0 39166000.0 21776500.0 13259300.0 True False 32568264.347991835 21659185.67220316 16031758.325923571 1.0 0.6650396054507175 0.4922509273022433 24.95696350082387 -13.999999999999751 0.08433883393700517 2.762386990499584 0.015263195976326456 0.9998681628085345 0.002420206205628591 12.216256614500475 0.08294520734125212 3.94227799971307 0.4309934183501694 1.0000000000005726e-14 13.999999999999751 -2.7471237945232576 TIIPLISQCTPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIIPLISQCTPK 12 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 125478000.0 31888000.0 42381000.0 51209000.0 False True 41805476.80383125 36057919.99984415 45910383.91141399 1.0 0.8625166546728545 1.0981906539864306 25.317188621832017 -6.748578479989053 1.6551737934674078 0.919020673269467 1.098606966953924 0.6428158932873533 0.057767672324176234 0.30252491779893986 1.6302265959825448 0.027576188195746993 0.06704597705005576 1.7841095585850454e-07 6.748578479989053 0.179586293684457 TIIPLISQCTPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIIPLISQCTPK 12 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 266239000.0 41236000.0 182800000.0 42203000.0 False True 62558026.75541047 150177911.7770812 33861558.55176797 1.0 2.400617787454313 0.5412823950499586 25.898691671180956 -6.705134611952371 1.8122701761780524 1.8652756760794151 0.5461749143936991 0.44218755954049815 0.5906759298272107 0.3848897392417278 2.460918960583764 0.2596636909012774 0.6636579050735176 1.9718114676269427e-07 6.705134611952371 -1.319100761685716 TIIPLISQCTPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIIPLISQCTPK 12 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 151819000.0 31888000.0 68145000.0 51786000.0 False True 43677855.340797834 65134128.5746199 39555213.366148464 1.0 1.4912391660810453 0.9056125365478153 25.38039868335491 -6.6842089840283485 1.886828808877285 1.3096297198648081 0.9077574723367857 0.3435202137324579 0.20800986927412862 0.4292492449773549 2.9580569708956452 0.08834204858756885 0.23175625219501372 2.0691454291504554e-07 6.6842089840283485 -0.4018722475280224 TIIPLISQCTPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIIPLISQCTPK 12 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 75032000.0 38967000.0 13989000.0 22076000.0 False True 32402787.03079703 13913638.480400914 26691989.5321087 1.0 0.42939634998609166 0.823755978358882 24.94961457184565 -10.172250719844502 5.51417852224834 1.0000101822729157 0.6265761641724604 0.5445276446557017 0.1609966441113163 2.015365185315752e-05 3.0251739901707103e-06 0.15588857860369612 0.051961443453177644 6.725882564423045e-11 10.172250719844502 -0.3734340181004553 TIIPLISQCTPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIIPLISQCTPK 12 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 136788000.0 41236000.0 52454000.0 43098000.0 False True 53380814.88308101 49534888.78922827 35254606.22282364 1.0 0.9279530276509191 0.6604358944321315 25.669817993273405 -6.946586845850902 0.5951437148421523 1.0030483015797402 0.5717602221711189 0.9989054243537014 0.004833032866373478 0.08488608796664687 0.04186373832062184 0.004984396869038622 0.022446574659540957 1.130871226445755e-07 6.946586845850902 -0.43128807940862135 TIIQNPTDQQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIIQNPTDQQK 11 0 Q9UQ80;Q9UQ80-2;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 34954300.0 5440300.0 17268000.0 12246000.0 False True 7132285.983940139 14691681.71013679 10978901.391926708 1.0 2.059883989960335 1.539324336776181 22.765933121325265 -10.142860088754661 4.595948410149972 0.9999090377944745 1.7996041633816926 0.7587990736986583 0.2125175885439199 25306043.60486822 55848280.21205642 14487.507044560718 0.07275042352465763 7.196807912604534e-11 10.142860088754661 0.7996951255872181 TIIQNPTDQQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIIQNPTDQQK 11 0 Q9UQ80;Q9UQ80-2;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 41538900.0 13578000.0 7073900.0 20887000.0 False True 13146973.822221434 9898545.159901181 15416068.103431398 1.0 0.752914343160123 1.172594416927694 23.64822742159204 -6.747157531664229 1.6603083386532198 0.8542162799167025 1.1732536385150114 0.6366665639411044 0.10381590495599884 0.30503261865366454 1.6534728197125168 0.04941297855844533 0.12032419881327339 1.7899564652468681e-07 6.747157531664229 0.31903735859830895 TIIQNPTDQQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIIQNPTDQQK 11 0 Q9UQ80;Q9UQ80-2;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 104094000.0 14832000.0 78485000.0 10777000.0 False True 22501228.364444833 64478738.543896094 8646921.226273092 1.0 2.865565270462378 0.38428663032176796 24.423500425961414 -6.705511096330177 1.810916236766625 2.1521156844044604 0.3907824547345655 0.4438739866928574 0.7867131685764407 0.38418174171012676 2.452966568872488 0.3460655977223493 0.8840837725575805 1.9701028699637724e-07 6.705511096330177 -1.761333229669895 TIIQNPTDQQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIIQNPTDQQK 11 0 Q9UQ80;Q9UQ80-2;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 35915300.0 5440300.0 14047000.0 16428000.0 False True 7451725.928579481 13426357.092782822 12548044.745280316 1.0 1.8017781681004847 1.6839111993041782 22.829143182848156 -10.121357253393635 4.413576818328691 0.9999054075555381 1.742844683698307 0.9814678611107083 0.04811898869468035 16782901.042214382 3.316901070430534 16780.803936063014 0.016472409692770768 7.562105754813572e-11 10.121357253393635 0.7429392761427688 TIIQNPTDQQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIIQNPTDQQK 11 0 Q9UQ80;Q9UQ80-2;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 26048600.0 13578000.0 8278200.0 4192400.0 False True 11290708.607389897 8233603.693505944 5069011.4565325435 1.0 0.7292371081224217 0.44895423598256873 23.428632697026316 -6.970691440094777 0.24109925391905665 1.0992796318228892 0.07079389399216639 0.999987284194077 0.0008022215872864238 0.07607895515326518 0.008223168798115394 0.006648007119969432 0.027271522420165496 1.0698146970346179e-07 6.970691440094777 -1.0284857378307228 down TIIQNPTDQQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIIQNPTDQQK 11 0 Q9UQ80;Q9UQ80-2;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 40533000.0 14832000.0 12959000.0 12742000.0 False True 19200316.382429354 12237820.258123487 10423086.743960714 1.0 0.6373759689357303 0.5428601558617606 24.194626748053864 -13.999999999999998 0.18876760902184628 2.935679028494898 0.47420634343827095 0.9994901322199813 0.004449103483538186 12.33090044386836 0.13777856367244173 8.77580641163412 0.06564241727772287 1.0000000000000041e-14 13.999999999999998 -2.461472685056627 TIIQNPTDQQK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIIQNPTDQQKK 12 1 Q9UQ80;Q9UQ80-2;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 7124900.0 1233600.0 2138800.0 3752500.0 True False 1194440.0432385018 2992833.9936946514 2769607.6774130412 1.0 2.5056376924371517 2.3187498552909913 20.187903006631664 -10.386181364630962 5.204246318316899 0.9990975339939623 2.412193773864133 0.9870351535534154 0.0762966400236291 0.0007993222535251103 9.427663473546216e-05 0.07391234976269175 0.024624634681893125 4.109780577456019e-11 10.386181364630962 1.4130962398701707 TIIQNPTDQQK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIIQNPTDQQKK 12 1 Q9UQ80;Q9UQ80-2;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 17998800.0 2241300.0 5192500.0 10565000.0 True False 3400215.960978303 4265857.805812329 8476823.119195998 1.0 1.2545843719247072 2.493024918557545 21.697194949786514 -6.940419607545859 0.655647100083693 0.9861929619842094 2.831157408043238 0.9982183600289606 0.027526820082089926 0.08757570128860283 0.05374158822020313 0.026881276599869233 0.10639455032102503 1.1470448317753364e-07 6.940419607545859 1.8449644460590287 up TIIQNPTDQQK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIIQNPTDQQKK 12 1 Q9UQ80;Q9UQ80-2;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 1 5255900.0 1233600.0 2179300.0 1843000.0 True False 1025793.0577460738 2167559.678342818 2228362.778930801 1.0 2.1130574651240996 2.172331701900066 19.96830828206594 -10.872284712150828 0.5281161902251528 1.1706544372186013e-23 2.1683477689479393 0.9998036281818494 0.007556159889590357 2.5606218269477474 0.25633595484782684 3.1984022389009366 0.011461026696186578 1.3418849678844537e-11 10.872284712150828 2.1683477689479393 TIIQNPTDQQKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIIQNPTDQQKK 12 1 Q9UQ80;Q9UQ80-2;F8VR77 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 6948900.0 2040200.0 1841400.0 3067300.0 False True 2641079.1183543946 1738924.4712793098 2509082.873155758 1.0 0.6584143803926632 0.9500218511890394 21.33269609004456 -10.105414944568949 7.06504542658234 1.000000093645782 0.8042181171330206 0.37539684841882226 0.11904825143911153 1.755801253418257e-07 2.2245149157758043e-08 0.11526802876850206 0.03842265793489933 7.844857433057604e-11 10.105414944568949 -0.1957819765127614 TIISLDTSQMNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIISLDTSQMNR 12 0 A0A1B0GWA2;A0A2R8YEL0;O00116 A0A1B0GWA2 AGPS Alkyldihydroxyacetonephosphate synthase, peroxisomal 0 4593000.0 1170600.0 1607400.0 1815000.0 False True 1534667.9361065263 1367582.1855961261 1627201.2107093744 1.0 0.8911257956334847 1.060295307164367 20.54949509543578 -6.7329122590825 1.7124764501273888 0.9346935114872184 1.0602517997345846 0.5727544269357884 0.04575867657738227 0.33081508822668526 1.9018522409155272 0.021163272179431345 0.0523456786161241 1.8496422661774252e-07 6.7329122590825 0.12555828824736626 TIISLDTSQMNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIISLDTSQMNR 12 0 A0A1B0GWA2;A0A2R8YEL0;O00116 A0A1B0GWA2 AGPS Alkyldihydroxyacetonephosphate synthase, peroxisomal 0 4904400.0 1170600.0 2043000.0 1690800.0 False True 1603402.4542755268 1952733.5047024493 1291467.8631190634 1.0 1.2178686015450577 0.8054545879453539 20.612705156958672 -6.763199916431804 1.600693309496365 1.1260471263783745 0.803718920550822 0.7037962215366755 0.09168207991519087 0.277572426276375 1.4024278113697264 0.0451791588946666 0.10822073217879646 1.7250436291836774e-07 6.763199916431804 -0.3223282058275525 TIK(ub)QTHSQELCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIKQTHSQELCK 12 1 P52732 P52732 KIF11 Kinesin-like protein KIF11 1 22165700.0 0.0 5973700.0 16192000.0 True False 0.0 4907646.562268871 12991644.102794288 0.0 TILEMLLGFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TILEMLLGFLK 11 0 Q96T76-9;Q96T76;Q96T76-8;Q96T76-5 Q96T76-9 MMS19 MMS19 nucleotide excision repair protein homolog 0 78483000.0 19367000.0 32693000.0 26423000.0 False True 29381154.917354576 26858678.71842514 21200482.468387663 1.0 0.9141464586390549 0.7215673627541839 24.808387770820236 -6.95774123221898 0.4661825946356207 1.0052798624279353 0.6225897753219513 0.999677014929311 0.0020922649320393384 0.08051815527605134 0.024189499847252355 0.002644015906506357 0.015899370007933854 1.102195840606913e-07 6.95774123221898 -0.38269008710598407 TILETSFHQHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TILETSFHQHR 11 0 Q5M775-4;Q5M775;Q5M775-5;Q5M775-3;Q5M775-2 Q5M775-4 SPECC1 Cytospin-B 0 4731900.0 1178300.0 1233500.0 2320100.0 False True 1544762.7106734298 1049466.608145342 2080038.307970698 1.0 0.679370754416925 1.3465099161177434 20.558953813650398 -6.776008737030066 1.551264927164375 0.817507890074381 1.3511615012486486 0.7530464300266989 0.13538089079616064 0.25683671679481984 1.2204431298657887 0.06875476377242816 0.16279252172114167 1.6749091802746464e-07 6.776008737030066 0.5336536111742677 TILGTIMNTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TILGTIMNTIK 11 0 Q5T1M5;Q5T1M5-2 Q5T1M5 FKBP15 FK506-binding protein 15 0 2090450.0 1272900.0 550260.0 267290.0 False True 1232492.486250233 769981.6875679924 197278.73047188084 1.0 0.624735400952102 0.16006485449017768 20.23314742072852 -7.522833069875543 0.43749538095507606 1.027682291555801 9.429858983104515e-23 0.9982880804989938 0.014214458895502024 0.11835273493642937 0.05769108241006202 0.020535086627594328 0.06833728011613034 3.0003155311107393e-08 7.522833069875543 -1.027682291555801 down TILMMGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TILMMGR 7 0 P13639 P13639 EEF2 Elongation factor 2 0 67132200.0 18231800.0 17485700.0 31414700.0 False True 23902066.35700235 14876901.718724754 28164208.195080824 1.0 0.6224106943944793 1.1783168774790818 24.51063201020567 -6.723750188800881 1.7454584073759167 0.771215037563619 1.177663324685365 0.5303739626651753 0.1588214565608159 0.3480515899746928 2.074194271002133 0.07218783232890205 0.1804488702539019 1.8890776559118287e-07 6.723750188800881 0.40644828712174597 TILMMGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 TILMMGR 7 0 P13639 P13639 EEF2 Elongation factor 2 0 31932650.0 12320000.0 7864150.0 11748500.0 False True 11928908.343627064 11004346.106000485 8671215.40255488 1.0 0.9224939775716762 0.7269077062854136 23.507958687186257 -6.955260803491262 0.497751135695796 1.003994503985221 0.6370035718412954 0.9995520664300677 0.002432017513203657 0.08143952947282318 0.027733233013311258 0.0028643370828915536 0.01613300803319226 1.1085089310867071e-07 6.955260803491262 -0.36699093214392553 TILMMGR ddPTM_RPMI8226_Bortezomib_8h_R1 2 TILMMGR 7 0 P13639 P13639 EEF2 Elongation factor 2 0 129450100.0 28226500.0 80564500.0 20659100.0 False True 42821664.13356268 66187135.52168848 16575819.8297948 1.0 1.5456460383054675 0.3870895763904476 25.351837526973423 -6.778632492935173 1.5411943979864209 1.3095055602547887 0.3783012725247192 0.7625283430938865 0.2306170015062813 0.25270185739049045 1.1854916204619514 0.11786738540100414 0.2784376575449711 1.6648208529882747e-07 6.778632492935173 -0.9312042877300695 down TILMMGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TILMMGR 7 0 P13639 P13639 EEF2 Elongation factor 2 0 56368000.0 18231800.0 15117200.0 23019000.0 False True 24972589.15586924 14449272.11810467 17582386.291186247 1.0 0.5786052870977015 0.7040674149341821 24.57384207172856 -10.588171035764551 9.578907470091883 1.000040720754913 0.6413363510159436 0.9159418647878765 0.05121969920720184 4.45471289434219e-05 1.9152174095818446e-06 0.04959885091826332 0.016531086835603823 2.5812434337846342e-11 10.588171035764551 -0.35870436973896935 TILMMGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TILMMGR 7 0 P13639 P13639 EEF2 Elongation factor 2 0 25508400.0 11016000.0 7801300.0 6691100.0 False True 9160292.091545677 7759272.848463197 8090178.073849091 1.0 0.8470551780356955 0.8831790507330844 23.126962171173233 -10.63924328091983 6.5566644513458 1.0005815620956817 0.86511711438439 0.9489518044509868 0.014747509273643246 0.00012590266579491516 6.9273260826931805e-06 0.014339686852687656 0.004759738151238314 2.2948627631927664e-11 10.63924328091983 -0.13546444771129174 TILMMGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TILMMGR 7 0 P13639 P13639 EEF2 Elongation factor 2 0 86453300.0 28226500.0 31273100.0 26953700.0 False True 36539760.67749742 29532724.4937357 22048403.168316882 1.0 0.8082353016592986 0.6034085270267009 25.122963849065872 -6.970287789674777 0.251217943244434 1.0640362270013002 0.34159919063489086 0.9999845397292232 0.0006367030719576222 0.07620943462022786 0.00869541279559082 0.004530952772159802 0.019591872672137568 1.0708094872344074e-07 6.970287789674777 -0.7224370363664093 TILPK(ub)NNPPTIVHDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TILPKNNPPTIVHDK 15 1 O60784-3;O60784-4;O60784;O60784-2;V9GZ68;H7BYN7;V9GYF4;B0QY02;Q6UW50;B0QY01 O60784-3 TOM1 Target of Myb protein 1 1 16787900.0 7484600.0 6756500.0 2546800.0 True False 7247005.4698629035 9454405.684682034 1879716.6776377186 1.0 1.3045948045711755 0.25937839918220434 22.788953552558255 -6.828720724262608 1.3336725801053926 1.162903556637517 0.2319909329726787 0.9032813549057521 0.1364992612300158 0.18239521472539041 0.6349460935319696 0.08037161248116168 0.18496414094414787 1.4834717341097813e-07 6.828720724262608 -0.9309126236648383 down TILPK(ub)NNPPTIVHDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TILPKNNPPTIVHDK 15 1 O60784-3;O60784-4;O60784;O60784-2;V9GZ68;H7BYN7;V9GYF4;B0QY02;Q6UW50;B0QY01 O60784-3 TOM1 Target of Myb protein 1 1 24333900.0 10557100.0 8569000.0 5207800.0 True False 16015892.52739215 7039795.000097412 4178476.047340175 1.0 0.43955058939470126 0.26089560979468884 23.933000862509157 -13.999999999999998 0.15997501329998337 3.7599888772497136 0.08522052947712105 0.999536433123042 0.006779370469267172 12.009512405978057 0.12639518247555084 10.2848175004418 0.1601069560906018 1.0000000000000041e-14 13.999999999999998 -3.6747683477725928 TILPK(ub)NNPPTIVHDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TILPKNNPPTIVHDK 15 1 O60784-3;O60784-4;O60784;O60784-2;V9GZ68;H7BYN7;V9GYF4;B0QY02;Q6UW50;B0QY01 O60784-3 TOM1 Target of Myb protein 1 1 4873100.0 1381000.0 2375800.0 1116300.0 True False 1891593.0201217325 2270829.3002800173 852652.9309201633 1.0 1.2004851340241673 0.45075918648996244 20.8511702927739 -6.835553957431568 1.3029329264196088 1.1067865573231779 0.42820004336582124 0.916526559646504 0.0915640106042205 0.17405739615444343 0.5759010918382267 0.05514285655982663 0.12692345122798446 1.4603133065415176e-07 6.835553957431568 -0.6785865139573566 down TILPK(ub)NNPPTIVHDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TILPKNNPPTIVHDK 15 1 O60784-3;O60784-4;O60784;O60784-2;V9GZ68;H7BYN7;V9GYF4;B0QY02;Q6UW50;B0QY01 O60784-3 TOM1 Target of Myb protein 1 1 17153000.0 7484600.0 8382400.0 1286000.0 True False 6223776.523999882 8337242.347423879 1554896.6542078177 1.0 1.3395793237874358 0.24983169755724463 22.56935882799253 -6.822987339734109 1.3589439254141318 1.1824970037660292 0.2244905165243618 0.8911096157552223 0.1502396958808244 0.18962631922010978 0.6872773939671126 0.08686034585051504 0.20005310877257412 1.503185785330506e-07 6.822987339734109 -0.9580064872416674 down TILPLINFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TILPLINFK 9 0 A0A0A0MRF9;P16885 A0A0A0MRF9 PLCG2 Phosphoinositide phospholipase C;1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 0 3314080.0 874080.0 1177700.0 1262300.0 False True 1197250.9971238272 1125665.3198668992 964170.7378845472 1.0 0.9402082959806262 0.8053204718148392 20.19129420643912 -6.95762305286442 0.467729488262732 1.0036425059619032 0.7363776035885436 0.9996716284086317 0.0014754885211217736 0.0805613787885079 0.024353209635479253 0.0018571858402167641 0.011134949477316247 1.1024958087683524e-07 6.95762305286442 -0.26726490237335954 TILQHLSEAWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TILQHLSEAWR 11 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 13611100.0 4172900.0 4590000.0 4848200.0 False True 5470712.3104210785 3905189.8916798634 4346554.771218287 1.0 0.7138357256039447 0.7945134974359005 22.38329725971077 -10.027205081637728 6.789457813167205 1.0000000610768565 0.7541746115199223 0.9252558131702686 0.03293656242883128 3.044931131297728e-08 4.339511438538781e-09 0.03189069752055853 0.01063022981401512 9.392796611336316e-11 10.027205081637728 -0.2458254495569342 TILQHLSEAWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TILQHLSEAWR 11 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 9757200.0 4638800.0 1806500.0 3311900.0 False True 4491543.833150744 2527844.8707730495 2444414.035129719 1.0 0.562800890890963 0.5442257998437483 22.098779982577085 TILQHLSEAWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TILQHLSEAWR 11 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 14291100.0 3633000.0 5584700.0 5073400.0 False True 5511526.607876753 4588066.651539739 4070640.266249782 1.0 0.8324493335444922 0.7385685592866883 22.394020547751367 -13.9999999921885 0.0680690628258333 1.9856213959763087 0.38388163115857377 0.9999308131356249 0.000899410720876373 12.380331773905544 0.06975713967791831 1.9614708448969238 0.32772139800163635 1.0000000179866454e-14 13.9999999921885 -1.601739764817735 TILQHLSEAWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TILQHLSEAWR 11 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 15822400.0 4172900.0 6155000.0 5494500.0 False True 5715733.898382314 5883051.748136841 4196812.262779574 1.0 1.02927320493382 0.7342560618448962 22.44650732123366 -6.882499517257805 1.0658045837841832 1.018817281523795 0.7123235440908563 0.9756445233493724 0.02071132808626146 0.1254370627870096 0.2591255121871835 0.014934569780077638 0.03635488733023426 1.3106914992709337e-07 6.882499517257805 -0.30649373743293873 TILQHLSEAWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TILQHLSEAWR 11 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 10110800.0 4638800.0 2564900.0 2907100.0 False True 3857367.733683921 2551082.3746072133 3514961.169088299 1.0 0.6613531689836687 0.9112331029251879 21.87918525801136 -10.458536413581582 5.37897863781663 1.0002613950787884 0.7862931359544268 0.49373321726929154 0.10201305585285345 0.0003201703760179718 3.222905133114612e-05 0.09889349301938385 0.032924572201151595 3.4790733600679827e-11 10.458536413581582 -0.21396825912436157 TILSLMTR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TILSLMTR 8 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 98068200.0 31969000.0 25589000.0 40510200.0 False True 41911668.58823642 21771220.945140764 36318593.10527757 1.0 0.5194548840093522 0.8665508754159053 25.32084862342892 -9.848643587645766 5.639991234336988 1.0000000985131554 0.6930028797113 0.5105374538659629 0.1417013451232809 1.7561999181439216e-07 3.552447396100469e-08 0.13720178242537628 0.04573391248245499 1.4169561560164632e-10 9.848643587645766 -0.3069972188018554 TILSLMTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TILSLMTR 8 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 57896700.0 23242000.0 9833700.0 24821000.0 False True 22504195.432027567 13760347.692068037 18319635.485961135 1.0 0.611456994036079 0.8140542300787594 24.42369065075357 -10.110451229687001 4.8695960229980875 1.0000133816087282 0.712755612055624 0.7282791020191266 0.08270997527332458 1.2016533600878486e-05 2.1950756711568937e-06 0.08008731844018364 0.026694529732351636 7.754410187874154e-11 10.110451229687001 -0.2872577695531042 TILSLMTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TILSLMTR 8 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 60521000.0 14591000.0 25552000.0 20378000.0 False True 22135613.74498479 20992045.96131278 16350279.368005317 1.0 0.9483381036167968 0.7386413386305929 24.399866039209122 -6.944538395671767 0.615898082539665 1.0023029790833782 0.673645053139137 0.9986999210477188 0.004074907238355215 0.08575588786930131 0.04563035533611316 0.004119241374980749 0.0177196537046613 1.1362178410011103e-07 6.944538395671767 -0.32865792594424115 TILSLMTR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TILSLMTR 8 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 105411800.0 31969000.0 28690000.0 44752800.0 False True 43788803.22974059 27422380.934857167 34183110.35284764 1.0 0.6262418452265981 0.7806358665137272 25.38405868495181 -10.13078272026528 5.198318457880191 1.0000089876471112 0.703438857138301 0.831062063349918 0.06303109524932696 6.565610508962726e-06 1.097836736333123e-06 0.06103144369875013 0.02034319851600861 7.399753959121458e-11 10.13078272026528 -0.2965701305088102 TILSLMTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TILSLMTR 8 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 55042000.0 23242000.0 14502000.0 17298000.0 False True 19326752.79518013 14423874.84757837 20914931.823084645 1.0 0.7463165178568185 1.0821751612769936 24.204095926187847 -6.704706377907142 1.8143200232675172 0.8431991935911838 1.081260155834883 0.4397766730895323 0.10699437404512888 0.3858406026619759 2.472420016295896 0.04699215799247779 0.12014380986989583 1.9737567220108693e-07 6.704706377907142 0.23806096224369933 TILSLMTR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TILSLMTR 8 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 67033600.0 17516000.0 30899000.0 18618600.0 False True 22674807.291979007 29179443.48759605 15230205.842968678 1.0 1.2868662172894405 0.6716796154804021 24.434586953880984 -6.779895626652315 1.536175456724785 1.1624523914493914 0.6668136073654602 0.7670531202134891 0.12130762773749586 0.25073728599050527 1.16869740217707 0.06219550298771789 0.14677432969495077 1.6599858014245653e-07 6.779895626652315 -0.49563878408393114 TILSNQTVDIPENVDITLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TILSNQTVDIPENVDITLK 19 0 P32969;D6RAN4;E7ESE0 P32969 RPL9 60S ribosomal protein L9 0 61500000.0 28066000.0 11907000.0 21527000.0 False True 27175060.1925517 16661527.194184694 15888432.903842922 1.0 0.6131183179035381 0.5846696489819632 24.695779895026206 -13.999999999999998 0.3703699438685516 6.4015045876585095 0.5817374684948783 0.9997915331442935 0.0027351942667366578 22.863865957364812 0.19757628032524535 98.06823583351853 0.007941834467178388 1.0000000000000041e-14 13.999999999999998 -5.8197671191636315 TILSNQTVDIPENVDITLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TILSNQTVDIPENVDITLK 19 0 P32969;D6RAN4;E7ESE0 P32969 RPL9 60S ribosomal protein L9 0 249898000.0 62733000.0 129690000.0 57475000.0 False True 95170547.39662342 106545806.22740506 46115041.05781256 1.0 1.1195249911022915 0.4845516004613071 26.50401183334289 -6.858025106455575 1.1957247769381572 1.0645376992912068 0.45495089263580973 0.9511862550183304 0.060871281829233716 0.14885325356072768 0.40554305063979273 0.03973646267075663 0.09255718756304923 1.386675663180835e-07 6.858025106455575 -0.6095868066553971 down TILSNQTVDIPENVDITLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TILSNQTVDIPENVDITLK 19 0 P32969;D6RAN4;E7ESE0 P32969 RPL9 60S ribosomal protein L9 0 52427000.0 28066000.0 24361000.0 0.0 False True 23338122.53461519 24229762.457720105 0.0 1.0 1.038205297867574 0.0 24.476185170460482 -6.996470371716754 1.127248138855935 1.0347806740215277 1.2545736986525857e-19 0.9826436972171391 0.06332410352045162 0.09279185808641088 0.23104759698555863 0.04727701962489772 0.08689790872729992 1.008160385376497e-07 6.996470371716754 -1.0347806740215277 down TILSNQTVDIPENVDITLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TILSNQTVDIPENVDITLK 19 0 P32969;D6RAN4;E7ESE0 P32969 RPL9 60S ribosomal protein L9 0 157522000.0 62733000.0 50357000.0 44432000.0 False True 81209105.15230188 47554588.6826394 36345831.910819456 1.0 0.5855819811516721 0.44755858154889705 26.27513815543534 -13.999999999999998 0.1536169955691866 3.0158684807832565 0.3018436344060356 0.9995546188575181 0.004954254543574646 11.97319086060777 0.12361194317729883 7.198062842511054 0.13182405406941947 1.0000000000000041e-14 13.999999999999998 -2.714024846377221 TILSNQTVDIPENVDITLK(ub)GR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TILSNQTVDIPENVDITLKGR 21 1 P32969;D6RAN4;E7ESE0 P32969 RPL9 60S ribosomal protein L9 1 51050400.0 26196000.0 16810000.0 8044400.0 True False 34343209.68242487 14302013.524866803 7212042.655333602 1.0 0.4164437062557334 0.20999908634120365 25.033521542704907 -12.895224596116776 0.16027009014936058 3.0117016964887697 1.6162037021330127e-20 0.9995366797153349 0.007200949948219903 7.924274668844407 0.11726833366634722 5.218233769730531 0.18149703558765984 1.2728446570382166e-13 12.895224596116776 -3.0117016964887697 TILSNQTVDIPENVDITLK(ub)GR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TILSNQTVDIPENVDITLKGR 21 1 P32969;D6RAN4;E7ESE0 P32969 RPL9 60S ribosomal protein L9 1 1161208500.0 254820000.0 678350000.0 228038500.0 True False 246730878.58141586 949218692.5485166 168308375.84164023 1.0 3.847182395677706 0.6821536761403056 27.87836304055991 -6.669669989977657 1.9387288310686308 2.81785015422287 0.6950083634792057 0.27756837726495065 1.2095100073243001 0.46183733856886566 3.3463832413975774 0.5023284871284656 1.3425825288368531 2.139587293319337e-07 6.669669989977657 -2.1228417907436645 TILSNQTVDIPENVDITLK(ub)GR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TILSNQTVDIPENVDITLKGR 21 1 P32969;D6RAN4;E7ESE0 P32969 RPL9 60S ribosomal protein L9 1 1354773000.0 500176000.0 402547000.0 452050000.0 True False 758803559.7636578 330709342.73593354 362702119.3594461 1.0 0.4358299832422222 0.47799211626315485 29.499151205957578 -10.56300958344212 6.222809635882491 1.001036484451933 0.45691104975268854 0.9955000693397897 0.01721261872810576 0.00024793052845983594 1.7410602077623608e-05 0.016694156729254575 0.0055553488065476185 2.7352083686429687e-11 10.56300958344212 -0.5441254346992446 TILSNQTVDIPENVDITLK(ub)GR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TILSNQTVDIPENVDITLKGR 21 1 P32969;D6RAN4;E7ESE0 P32969 RPL9 60S ribosomal protein L9 1 38661700.0 26196000.0 7894300.0 4571400.0 True False 35881369.120281644 7545503.723040896 3491729.470938309 1.0 0.21029029571716823 0.09731316158068891 25.0967316042278 -13.999999999999998 0.2738898266797763 7.2245902746591835 0.06120328999763403 0.9995917504542131 0.008113578157210944 15.077388053984048 0.16570713475381485 52.37862017662128 0.046027211977711605 1.0000000000000041e-14 13.999999999999998 -7.16338698466155 TILSNQTVDIPENVDITLK(ub)GR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TILSNQTVDIPENVDITLKGR 21 1 P32969;D6RAN4;E7ESE0 P32969 RPL9 60S ribosomal protein L9 1 777496000.0 254820000.0 391076000.0 131600000.0 True False 211894120.44005692 388969195.9654917 159116951.55034906 1.0 1.8356771540318781 0.7509266949922847 27.658768315994188 -6.700939336147431 1.8272916319397394 1.5184491099834538 0.7540764752867563 0.42205793666384606 0.3526910034243428 0.39361671973562934 2.5557527944214256 0.15393527853827063 0.395456043611707 1.9909514229914957e-07 6.700939336147431 -0.7643726346966976 TILSNQTVDIPENVDITLK(ub)GR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TILSNQTVDIPENVDITLKGR 21 1 P32969;D6RAN4;E7ESE0 P32969 RPL9 60S ribosomal protein L9 1 1199518700.0 500176000.0 383209000.0 316133700.0 True False 647487691.9429609 361883082.28221595 258600610.40568584 1.0 0.5589034151310097 0.39939077394611966 29.270277528050027 -13.999999999999796 0.14153313693046268 3.1100717654925245 0.20558471591746 0.9995968925668921 0.0051001207580277505 11.935891285529127 0.1179795510178532 6.94997244424657 0.17344501871302906 1.0000000000004703e-14 13.999999999999796 -2.9044870495750645 TILTLTGVSTLGDVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TILTLTGVSTLGDVK 15 0 A6NDG6;H3BV17 A6NDG6 PGP Phosphoglycolate phosphatase 0 8580900.0 2364500.0 3227300.0 2989100.0 False True 3099882.3978505754 2745799.419916872 2679816.605471837 1.0 0.8857753512909972 0.8644897649439838 21.563782053450765 -13.999999999999876 0.23627180892366767 1.7426302918510426 0.8547393599442067 0.999518961889145 0.001304998749661893 13.494792667219082 0.1538657839201462 4.7182010499866855 0.010633811044835531 1.0000000000002864e-14 13.999999999999876 -0.8878909319068359 TILTLTGVSTLGDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TILTLTGVSTLGDVK 15 0 A6NDG6;H3BV17 A6NDG6 PGP Phosphoglycolate phosphatase 0 16165100.0 5487900.0 5200800.0 5476400.0 False True 5313689.618424589 7277506.561813713 4041966.551521595 1.0 1.3695769012514059 0.7606704270995722 22.341282529362353 -6.742433729065145 1.6780939596217688 1.219277939262327 0.7601421132920152 0.6156972266864467 0.1552739372273701 0.31342578612498295 1.7339618817976616 0.07317804064831993 0.17907346650100653 1.8095320137599592e-07 6.742433729065145 -0.4591358259703118 TILTLTGVSTLGDVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TILTLTGVSTLGDVK 15 0 A6NDG6;H3BV17 A6NDG6 PGP Phosphoglycolate phosphatase 0 20911300.0 4527800.0 10159000.0 6224500.0 False True 6869003.626519241 8346047.077370716 4994224.846704733 1.0 1.215030233081991 0.727066852523337 22.711669415481218 -6.786907983439372 1.5085229756090568 1.1206657829224291 0.7223001960232925 0.7911884868132562 0.09124427851216951 0.2399956754028063 1.0789355160218033 0.04761684073647954 0.11174568587570659 1.63339798900245e-07 6.786907983439372 -0.3983655868991366 TILTLTGVSTLGDVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TILTLTGVSTLGDVK 15 0 A6NDG6;H3BV17 A6NDG6 PGP Phosphoglycolate phosphatase 0 14469700.0 2364500.0 5414400.0 6690800.0 False True 3238719.5482098795 5175173.9049735395 5110570.841351454 1.0 1.5979073914670958 1.577960291182419 21.626992114973657 -10.073758018319799 4.594622359229612 0.9999676305559709 1.5879338413464854 0.9991374399347542 0.00814336966344784 5653761.038926951 0.0881657330023666 1951.6488234438664 0.0027876920258744046 8.43804780832416e-11 10.073758018319799 0.5879662107905145 TILTLTGVSTLGDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TILTLTGVSTLGDVK 15 0 A6NDG6;H3BV17 A6NDG6 PGP Phosphoglycolate phosphatase 0 10996700.0 5487900.0 2568700.0 2940100.0 False True 4563432.00519186 2554861.9032529728 3554861.316513534 1.0 0.5598553677027032 0.7789885578374204 22.12168780479663 -10.230590632908509 4.723652973515414 1.0000767093738612 0.6694219627689305 0.7521306271642328 0.08946075026031525 7.22875831368459e-05 1.1774471751082176e-05 0.0866400365942597 0.028873332990895683 5.880433825729192e-11 10.230590632908509 -0.33065474660493066 TIMHLMINNTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIMHLMINNTK 11 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3;A0A0D9SFB1;Q05193;Q05193-3;Q05193-5;Q05193-2;A0A0D9SFE4;A0A0U1RQP1 P50570 DNM2;DNM1 Dynamin-2;Dynamin-1 0 18599000.0 5734100.0 6503000.0 6361900.0 False True 7517460.629103388 5532777.748495462 5703631.615653976 1.0 0.7359902527557847 0.7587178566087485 22.841813976374063 -10.751852957884504 6.890673654372749 1.0049273344926692 0.747354054682281 0.9939672387490055 0.009278505419312376 0.0007117069076648481 2.5629965489415374e-05 0.009103559566956375 0.0029946247472243414 1.7707083779375527e-11 10.751852957884504 -0.25757327981038824 TIMHLMINNTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIMHLMINNTK 11 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3;A0A0D9SFB1;Q05193;Q05193-3;Q05193-5;Q05193-2;A0A0D9SFE4;A0A0U1RQP1 P50570 DNM2;DNM1 Dynamin-2;Dynamin-1 0 16006300.0 5734100.0 5884200.0 4388000.0 False True 7854151.728225945 5624216.587552688 3351644.773696743 1.0 0.7160819885030484 0.42673542473743314 22.905024037896954 -6.970888957044935 0.23598979787460353 1.1092028134118903 0.02528686354101438 0.9999885095755494 0.0007933092273565411 0.07601528919431555 0.007990705758758074 0.0071172941367135725 0.028414026269747678 1.0693282563792172e-07 6.970888957044935 -1.083915949870876 down TIMHLMINNTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIMHLMINNTK 11 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3;A0A0D9SFB1;Q05193;Q05193-3;Q05193-5;Q05193-2;A0A0D9SFE4;A0A0U1RQP1 P50570 DNM2;DNM1 Dynamin-2;Dynamin-1 0 11310400.0 7736000.0 3574400.0 0.0 False True 6432826.762908245 3555143.997737151 0.0 1.0 0.5526565736599893 0.0 22.617021406515107 -7.775195650470176 0.6271633904818846 1.0033754806561734 2.8955694241253433e-19 0.987900516310458 0.04498928523267148 0.11779870537097238 0.15458976362373092 0.04322351805716728 0.0779118500171255 1.6780478841291012e-08 7.775195650470176 -1.0033754806561734 down TINEVENQILTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TINEVENQILTR 12 0 O43707;O43707-2;O43707-3;F5GXS2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;H7C144;H7C5W8;H0YJW3;H0YJ11 O43707 ACTN4;ACTN1 Alpha-actinin-4;Alpha-actinin-1 0 10524800.0 1555600.0 4705000.0 4264200.0 False True 2039406.6644518296 4003032.339946358 3822981.489094715 1.0 1.9628416488588507 1.8745557498324108 20.959718051539806 -10.536420814992638 5.968634360828537 0.9984287841780649 1.91869869934546 0.9931213993064384 0.03604256734961 0.0007545176991715349 5.860273595904187e-05 0.034941365698222364 0.011632688591633127 2.9078981088063972e-11 10.536420814992638 0.9202699151673951 TINEVENQILTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TINEVENQILTR 12 0 O43707;O43707-2;O43707-3;F5GXS2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;H7C144;H7C5W8;H0YJW3;H0YJ11 O43707 ACTN4;ACTN1 Alpha-actinin-4;Alpha-actinin-1 0 5777600.0 1555600.0 4222000.0 0.0 False True 2130747.358509319 4035458.079713039 0.0 1.0 1.8939167347067674 0.0 21.022928113062697 -6.786181935318164 1.5630855428616999 1.5068050565211903 4.873701069485617e-19 0.7612085050281809 0.37802598922033376 0.24784117156344915 1.2044385174773924 0.1919673049812413 0.44117042761599395 1.6361309673178623e-07 6.786181935318164 -1.5068050565211903 TINK(ub)AWVESR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TINKAWVESR 10 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 11077700.0 5827700.0 3000300.0 2249700.0 True False 7640171.135527084 2552666.9350778027 2016922.6246462136 1.0 0.3341112247090651 0.26398919459636805 22.865173523502875 -13.999999999999998 0.31798334836162545 7.746433564496172 0.2497524129807018 0.9996893891150852 0.0058453773482316975 17.85819846198473 0.1797443155126021 80.06384785622565 0.02353186847738299 1.0000000000000041e-14 13.999999999999998 -7.49668115151547 TINK(ub)AWVESR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TINKAWVESR 10 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 17273800.0 2056300.0 8968100.0 6249400.0 True False 1991023.882061712 12549109.09802366 4612494.662018677 1.0 6.302842075921769 2.316644568443058 20.925079095417928 -6.573482147157389 2.292989878854668 4.6252620333974725 2.3255802021146907 0.0 2.3075376794899136 0.7192197237760203 7.10364885933092 0.8485840242867271 2.5835366472633616 2.6700405240698327e-07 6.573482147157389 -2.299681831282782 TINLYPLTNYTFGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TINLYPLTNYTFGTK 15 0 O43809 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 104354000.0 28835000.0 41066000.0 34453000.0 False True 37802964.23853724 34939112.874014296 30888134.05651244 1.0 0.9242426772024543 0.8170823288250064 25.171996028937443 -6.966214172507978 0.3365675690617601 1.0120950797958006 0.7256871484488082 0.9999360205150752 0.0006002100588155467 0.0775513535835597 0.013420531714803187 0.0015291319643375985 0.009298918565292988 1.0809007731654297e-07 6.966214172507978 -0.2864079313469924 TINLYPLTNYTFGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TINLYPLTNYTFGTK 15 0 O43809 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 254736900.0 117080000.0 72139700.0 65517200.0 False True 113363359.48635186 100945458.4135657 48356279.846130796 1.0 0.8904593059957685 0.4265600460786675 26.756379176900104 -6.943565579505474 0.6255161547629623 1.0050634852151208 0.28714581340744855 0.9985945824805315 0.009318208733879636 0.08617707380367055 0.04748090662707368 0.009337476674495845 0.03934314574775428 1.138765812530852e-07 6.943565579505474 -0.7179176718076723 down TINLYPLTNYTFGTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TINLYPLTNYTFGTK 15 0 O43809 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 131870000.0 41622000.0 51129000.0 39119000.0 False True 63143616.97579042 42004630.47729964 31387112.503533244 1.0 0.6652236993868189 0.4970749856722212 25.912133567301133 -13.999999999999995 0.08917903875088741 2.720425331231023 0.07027587596766169 0.9998462438789891 0.002592067542173434 12.17113867774445 0.08656539315211087 3.98095572640828 0.3837579947824859 1.0000000000000123e-14 13.999999999999995 -2.6501494552633615 TINLYPLTNYTFGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TINLYPLTNYTFGTK 15 0 O43809 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 162837000.0 28835000.0 50632000.0 83370000.0 False True 39496078.736575104 48394910.822366305 63679723.05904681 1.0 1.2253092552590668 1.6123049451001978 25.235206090460334 -6.962908710524292 0.39229521649979676 0.9768315736110049 1.8747389815291842 0.9998633300212388 0.0029560872458358014 0.07867800904863537 0.01740852786782181 0.00499068851308155 0.0325221096353518 1.0891590124425449e-07 6.962908710524292 0.8979074079181792 TINLYPLTNYTFGTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TINLYPLTNYTFGTK 15 0 O43809 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 201103000.0 117080000.0 45887000.0 38136000.0 False True 97357207.52343565 45639797.62314358 46110061.2790586 1.0 0.4687870449874731 0.4736173361171957 26.53678445233438 -10.02244335373146 5.498530523592027 1.000002229279698 0.47120219055186957 0.9999374243846025 0.001971958097787897 5448451.232073724 3.4215424369732084 153.78326638266674 0.0006750537076315012 9.496348547085067e-11 10.02244335373146 -0.5288000387278284 TINLYPLTNYTFGTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TINLYPLTNYTFGTK 15 0 O43809 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 126203000.0 41622000.0 51950000.0 32631000.0 False True 53880499.492278524 49058936.83227985 26692492.822334126 1.0 0.9105137720430815 0.49540173298058154 25.683259889393582 -6.9414905852433435 0.645547098174229 1.0045660693246743 0.37837336337771477 0.9983526971728837 0.00892241970058545 0.08709314688769233 0.05156191992974206 0.008786733706580651 0.03549980565655153 1.144219684260914e-07 6.9414905852433435 -0.6261927059469595 down TIPDVFPHLPLIAITR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIPDVFPHLPLIAITR 16 0 K7EJE8;K7EKE6 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 68393000.0 31895000.0 20647000.0 15851000.0 False True 41814653.871619344 17566548.081375632 14210890.573528524 1.0 0.42010506975159945 0.33985431559852786 25.317505285059735 -13.999999999999998 0.27864179014011664 5.690912171932939 0.31537022605725634 0.999602175874288 0.005866193296812079 15.325255291840506 0.167197219545426 40.93384133540403 0.03195110621667824 1.0000000000000041e-14 13.999999999999998 -5.375541945875683 TIPDVFPHLPLIAITR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIPDVFPHLPLIAITR 16 0 K7EJE8;K7EKE6 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 41805000.0 10250000.0 20441000.0 11114000.0 False True 15549999.375374855 16793143.843738057 8917313.02856076 1.0 1.0799449850996043 0.5734606679587596 23.890411186616056 -6.866523632529361 1.1522447931490007 1.0443949789835139 0.5456839694732917 0.9610932024163857 0.043853062194250544 0.14023618139132282 0.35015276221803454 0.0295934050449203 0.06967493350654863 1.3598041662903491e-07 6.866523632529361 -0.4987110095102222 TIPDVFPHLPLIAITR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIPDVFPHLPLIAITR 16 0 K7EJE8;K7EKE6 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 141092000.0 31895000.0 20716000.0 88481000.0 False True 43687443.42996572 19800698.621348962 67583610.12339592 1.0 0.4532354623380739 1.546980203401867 25.380715346582626 -6.77078700620398 1.5714280005441579 0.686704521794827 1.553317191651636 0.7335606356234103 0.23048334586138536 0.26516218138872666 1.292353501330886 0.11560191357144325 0.2749837993365428 1.6951689690772433e-07 6.77078700620398 0.866612669856809 TIPDVFPHLPLIAITR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIPDVFPHLPLIAITR 16 0 K7EJE8;K7EKE6 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 245717000.0 130460000.0 53462000.0 61795000.0 False True 108483270.3579383 53173989.59462384 74716048.7922022 1.0 0.4901584310574097 0.6887333737789997 26.69289733510893 -10.157407944909826 5.314120567938746 1.0000136689331864 0.589445902418041 0.8507333360915189 0.08106788089562353 1.3129013482673132e-05 2.0816391998720777e-06 0.07849624894997324 0.02616454605167337 6.959724606458022e-11 10.157407944909826 -0.4105677665151455 TIPDVFPHLPLIAITR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIPDVFPHLPLIAITR 16 0 K7EJE8;K7EKE6 K7EJE8 LONP1 Lon protease homolog, mitochondrial 0 27455800.0 10250000.0 8430300.0 8775500.0 False True 13268827.057706386 7961146.394170709 7178449.044233809 1.0 0.5999887073324213 0.5410010254120123 23.661537508708506 -13.999999999999998 0.26955761015426594 4.080112147749838 0.5213367821965633 0.9995823775109364 0.00416681251351205 14.861429662828847 0.16435123691449996 25.078054348725672 0.024553177530760147 1.0000000000000041e-14 13.999999999999998 -3.5587753655532746 TIPGK(ub)QQLLIGAYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIPGKQQLLIGAYAK 15 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 14394000.0 3442200.0 5200800.0 5751000.0 True False 3332929.2451650207 7277506.561813713 4244640.573698182 1.0 2.1835166685194327 1.2735465596384181 21.668359260089755 -10.406815320153703 5.117240155134688 0.9993286021779192 1.7285316140789664 0.4608106990718781 0.3714937413240332 0.0028480097824616604 0.000330138031580074 0.3600059457955217 0.11989908944733488 3.919084972636215e-11 10.406815320153703 0.7292030119010472 TIPGK(ub)QQLLIGAYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIPGKQQLLIGAYAK 15 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 14843600.0 3442200.0 8998000.0 2403400.0 True False 2862341.8153157705 8949525.988036847 2905939.8279339545 1.0 3.1266447424796975 1.0152315884793706 21.44876453552403 -6.644526584141844 2.02839856500122 2.385904064541251 1.0241114003446905 0.17213675888857827 0.9089046952473931 0.5220019603722716 4.110258269199383 0.36423131071643955 1.0063680982113665 2.267114297733447e-07 6.644526584141844 -1.3617926641965605 TIPLYNLTGLSVSNGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIPLYNLTGLSVSNGK 16 0 K7EIG7;O94832;J3QRN6 K7EIG7 MYO1D Unconventional myosin-Id 0 3693900.0 0.0 1756000.0 1937900.0 False True 0.0 1494011.6448343908 1737384.6976494198 0.0 TIPLYNLTGLSVSNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIPLYNLTGLSVSNGK 16 0 K7EIG7;O94832;J3QRN6 K7EIG7 MYO1D Unconventional myosin-Id 0 3805400.0 0.0 1211800.0 2593600.0 False True 0.0 1158258.669113278 1981045.0968687052 0.0 TIPNDPGFVVTLSNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIPNDPGFVVTLSNR 15 0 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 10313400.0 2774200.0 3964700.0 3574500.0 False True 3637003.0653910143 3373182.2142795594 3204645.0290251523 1.0 0.9274620212388819 0.8811224437834289 21.794318711071114 TIPNDPGFVVTLSNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIPNDPGFVVTLSNR 15 0 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 12623700.0 3296300.0 2402900.0 6924500.0 False True 3191660.7608033973 3362390.500957962 5110765.719452796 1.0 1.0534924457671966 1.6012872615466582 21.60587588607376 -6.925808831673811 0.780411667781981 0.9902506563695718 1.7026217848613965 0.9956489277617563 0.01792338795334743 0.09487236025860668 0.08876946320531884 0.015939098764455945 0.05075565301168803 1.1862908163353512e-07 6.925808831673811 0.7123711284918247 TIPNDPGFVVTLSNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIPNDPGFVVTLSNR 15 0 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 26513500.0 7191500.0 19322000.0 0.0 False True 10910031.269073967 15873838.136524966 0.0 1.0 1.4549764107021044 0.0 23.3791519007652 -6.846202789266109 1.4148672806352582 1.2428624435066709 3.7972572398903414e-23 0.8896273886866886 0.20190045200889403 0.17825177871995382 0.7168314171566974 0.11462490491225427 0.24330519887522137 1.424942076436786e-07 6.846202789266109 -1.2428624435066709 down TIPNDPGFVVTLSNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIPNDPGFVVTLSNR 15 0 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 10624400.0 2774200.0 4138200.0 3712000.0 False True 3799896.709936069 3955360.6408025813 2835302.051039721 1.0 1.04091267282608 0.7461524003075923 21.857528772594005 -6.871792827093459 1.1245185324298546 1.023411567868903 0.7282874867608274 0.9664424480937909 0.02388438177364139 0.1351499892472144 0.31831585158338216 0.01646455031637978 0.039107963110975086 1.3434056574708347e-07 6.871792827093459 -0.29512408110807564 TIPNDPGFVVTLSNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIPNDPGFVVTLSNR 15 0 Q93009;A0A669KBL1;Q93009-3;H3BND8 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 0 9128600.0 3296300.0 3043000.0 2789300.0 False True 2741019.500849855 3026606.755011791 3372529.7337339567 1.0 1.1041901577399902 1.23039246261776 21.386281161508037 -6.968567068708852 0.2903950224331093 0.9754571267886205 1.3630266825363335 0.9999689365347822 0.0005249900290240122 0.07677061422733174 0.010686751252171701 0.002200148301537093 0.011439357321235645 1.07506056445452e-07 6.968567068708852 0.387569555747713 TIPSPYPASK(ub)ADIPSVAFSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIPSPYPASKADIPSVAFSSR 21 1 Q86SY2;Q8WV16-4;Q8WV16-3;Q8WV16-5;Q8WV16 Q86SY2 DCAF4 DDB1- and CUL4-associated factor 4 1 13952000.0 3738500.0 4645900.0 5567600.0 True False 3619823.363851438 6501032.098048436 4109278.535580248 1.0 1.795952853105914 1.1352152087354996 21.787487869308627 -10.237919825920562 4.570560529506271 0.9998480811913546 1.4655840309224648 0.39832565604000203 0.26974501377138055 0.00042085204814866386 7.017117679602394e-05 0.26126465489063405 0.08705982883655027 5.78202778204172e-11 10.237919825920562 0.4657359497311102 TIPSPYPASK(ub)ADIPSVAFSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIPSPYPASKADIPSVAFSSR 21 1 Q86SY2;Q8WV16-4;Q8WV16-3;Q8WV16-5;Q8WV16 Q86SY2 DCAF4 DDB1- and CUL4-associated factor 4 1 14218800.0 3738500.0 6523600.0 3956700.0 True False 3108728.393631398 6488456.0719667785 4784027.67628622 1.0 2.087173676947512 1.5389017857227 21.567893144742904 -9.978968841816368 5.163305794017956 0.9999960365979252 1.8130377313376302 0.7456783386998951 0.22383106232212002 153938698.318518 10.979612209582747 7956.302150908809 0.07662332618702444 1.0496177301129643e-10 9.978968841816368 0.813041694739705 TIPSWATLSASQLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIPSWATLSASQLAR 15 0 Q5SSJ5;Q5SWC8;Q5SSJ5-2;B0QZK4 Q5SSJ5 HP1BP3 Heterochromatin protein 1-binding protein 3 0 21200800.0 5171400.0 8576300.0 7453100.0 False True 6779755.479908834 7296749.470155572 6681924.707183486 1.0 1.0762555510709495 0.9855701620780778 22.692801811080432 -6.683700643889157 1.8885480398300971 1.0480858994127615 0.9859030522096556 0.3412261534891393 0.032292982574352994 0.43035378803446145 2.9706301005817117 0.01370426025371704 0.03597612830065833 2.0715687744633793e-07 6.683700643889157 -0.06218284720310596 TIPSWATLSASQLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIPSWATLSASQLAR 15 0 Q5SSJ5;Q5SWC8;Q5SSJ5-2;B0QZK4 Q5SSJ5 HP1BP3 Heterochromatin protein 1-binding protein 3 0 23423300.0 7892200.0 6411500.0 9119600.0 False True 7641666.43097187 8971645.385530801 6730903.1778643625 1.0 1.1740430528567032 0.8808161464080452 22.865455852813124 -6.745895883922472 1.66489194111612 1.1028416896272335 0.8804063083442822 0.6311672942367794 0.07312430631450391 0.30726675965170563 1.6743581856542462 0.034714542271102974 0.0846485630045225 1.7951639409019702e-07 6.745895883922472 -0.22243538128295126 TIPSWATLSASQLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIPSWATLSASQLAR 15 0 Q5SSJ5;Q5SWC8;Q5SSJ5-2;B0QZK4 Q5SSJ5 HP1BP3 Heterochromatin protein 1-binding protein 3 0 17429700.0 5171400.0 5856800.0 6401500.0 False True 7083406.331830216 5598027.210152374 4889597.5430309195 1.0 0.7903015791988247 0.69028900983117 22.756011872603324 -13.99999999930354 0.0981847250202316 2.041356225711911 0.4711488450680747 0.9998027752017306 0.0018123978567886646 12.09447293177704 0.09294366370432394 2.564092547916272 0.1956574918222936 1.000000001603658e-14 13.99999999930354 -1.5702073806438361 TIPSWATLSASQLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIPSWATLSASQLAR 15 0 Q5SSJ5;Q5SWC8;Q5SSJ5-2;B0QZK4 Q5SSJ5 HP1BP3 Heterochromatin protein 1-binding protein 3 0 18875700.0 7892200.0 6127600.0 4855900.0 False True 6562713.983741538 6094589.402566636 5871246.23885517 1.0 0.9286690563790174 0.8946369220722693 22.6458611282474 -13.999999838901873 0.09812536544217335 1.354294127891496 0.8199985542504565 0.9998030548165281 0.0006161024167464199 12.094944127495829 0.09290312039315016 0.8720109758904764 0.06664276423906347 1.0000003709422141e-14 13.999999838901873 -0.5342955736410394 TIQCAK(ub)AQAGEGVRPSPMQLELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIQCAKAQAGEGVRPSPMQLELR 23 2 O00764;F2Z2Y4;O00764-2;O00764-3 O00764;O00764-3 PDXK Pyridoxal kinase 1 72218900.0 6822900.0 11438000.0 53958000.0 True False 10350838.120804396 9396799.53449811 43293177.64936851 1.0 0.9078298225542973 4.182577018797398 23.303244253556766 -6.900425979633448 0.9585951168194544 0.8654348962184908 4.529276611414949 0.9867763668820744 0.17507511461891323 0.11109158838867488 0.17566711392740586 0.13687177726441555 0.3568745615105335 1.2576911947153255e-07 6.900425979633448 3.663841715196458 up TIQCAK(ub)AQAGEGVRPSPMQLELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIQCAKAQAGEGVRPSPMQLELR 23 2 O00764;F2Z2Y4;O00764-2;O00764-3 O00764;O00764-3 PDXK Pyridoxal kinase 1 42049900.0 6822900.0 10622000.0 24605000.0 True False 8832378.54946584 10030876.362511579 20127142.468619794 1.0 1.1356936646604918 2.278790742029171 23.074370575649215 -6.929147310082245 0.7537574071579932 0.982056535224686 2.508447996757041 0.9963680711646512 0.03456382750746919 0.09308270260987216 0.07986644755663433 0.031331228398326125 0.10391948033577153 1.1772066043765405e-07 6.929147310082245 1.5263914615323553 up TIQFVDWCPTGFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIQFVDWCPTGFK 13 0 Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 Q71U36;Q9BQE3 TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 80307000.0 23599000.0 34905000.0 21803000.0 False True 30938517.533041082 29697310.058624342 19547034.70914404 1.0 0.9598814819394245 0.6318025641748543 24.882900733688537 -6.929689283965739 0.7493396082103219 1.0050470864469574 0.5649798444336418 0.9964767781885554 0.009789653962828581 0.09279961386700274 0.0784733898343213 0.008902396404574098 0.029736404366758267 1.1757384362913158e-07 6.929689283965739 -0.4400672420133156 TIQFVDWCPTGFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIQFVDWCPTGFK 13 0 Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 Q71U36;Q9BQE3 TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 35706000.0 19008000.0 10493000.0 6205000.0 False True 18404601.444453146 14682909.620272135 4579724.353990123 1.0 0.797784709687225 0.24883583422396677 24.133563172404756 -6.953673246685696 0.5169476251952493 1.0095530122900505 0.012697192541112427 0.9994589089498419 0.007382334820884842 0.08204343227775218 0.03011113632514342 0.008404470853110748 0.045330519114990496 1.1125684837474927e-07 6.953673246685696 -0.996855819748938 down TIQFVDWCPTGFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIQFVDWCPTGFK 13 0 Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 Q71U36;Q9BQE3 TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 240065000.0 63674000.0 127000000.0 49391000.0 False True 96598113.19293824 104335857.74447109 39628847.2011557 1.0 1.0801024398486752 0.4102445264329733 26.525491674040953 -6.877035992016427 1.0961358643877572 1.0479487985112181 0.3653788824055541 0.9712176753848748 0.05067369330144894 0.1302909070318049 0.2883932983299059 0.0356999089770664 0.0857218846806648 1.327284454896458e-07 6.877035992016427 -0.682569916105664 down TIQFVDWCPTGFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIQFVDWCPTGFK 13 0 Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 Q71U36;Q9BQE3 TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 106158000.0 23599000.0 40293000.0 42266000.0 False True 32324188.0389955 38512722.028867215 32283641.295593996 1.0 1.1914521095597497 0.9987456222147765 24.94611079521143 -6.647686921866487 2.0170453339226886 1.124460403164723 0.9995581281159327 0.1846854299020061 0.08176055879436979 0.5141777255757529 4.007129717362419 0.032906326566295004 0.09053777692872249 2.2506765091945568e-07 6.647686921866487 -0.12490227504879026 TIQFVDWCPTGFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIQFVDWCPTGFK 13 0 Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 Q71U36;Q9BQE3 TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 43693000.0 19008000.0 5797000.0 18888000.0 False True 15805994.19717683 5765770.410385586 22837393.471755266 1.0 0.36478378635716774 1.4448565010756704 23.913968447839032 -6.747369948356322 1.660057886078933 0.6253006905093789 1.4465177010115724 0.637387479887101 0.2668920422945693 0.3046510581496668 1.651069484226591 0.1270617199303918 0.3092702104818178 1.7890811981667374e-07 6.747369948356322 0.8212170105021935 TIQFVDWCPTGFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIQFVDWCPTGFK 13 0 Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 Q71U36;Q9BQE3 TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 172546000.0 63674000.0 63389000.0 45483000.0 False True 82427248.20218489 59861346.426590696 37205560.69499014 1.0 0.7262324987455296 0.45137453337916894 26.296617996133403 -6.971075926202672 0.23104735328916087 1.110329202580932 0.059414407684980595 0.9999896009149687 0.000722244616333514 0.07595510596570491 0.007769540630287293 0.007008176811149157 0.02724365186975759 1.0688679963909607e-07 6.971075926202672 -1.0509147948959514 down TIQFVDWCPTGFK(ub)VGINYQPPTVVPGGDLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIQFVDWCPTGFKVGINYQPPTVVPGGDLAK 31 1 Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 Q71U36;Q9BQE3 TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 132415000.0 41694000.0 13801000.0 76920000.0 True False 63252846.2396955 11338103.72229484 61716728.284766324 1.0 0.17925049063135126 0.9757146429568073 25.91462706359961 -9.481882878882702 11.97613035350276 0.9999999996842597 0.5774825667940793 0.2728479831184347 0.32515512860261725 0.0 0.0 0.31483009950296686 0.10494336650098893 3.296986137529167e-10 9.481882878882702 -0.4225174328901804 TIQFVDWCPTGFK(ub)VGINYQPPTVVPGGDLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIQFVDWCPTGFKVGINYQPPTVVPGGDLAK 31 1 Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 Q71U36;Q9BQE3 TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 99265900.0 41694000.0 9319900.0 48252000.0 True False 53973704.911610715 8801239.372149458 39470631.107329495 1.0 0.1630653183168116 0.7312937137068508 25.68575338569206 -10.152898218799033 6.878954548507339 1.0000008230182762 0.44717951606236384 0.5579143564130546 0.23197827101100787 2.928356831640615e-06 3.6005068896089636e-07 0.22461233308334405 0.07487066502563533 7.032371111350813e-11 10.152898218799033 -0.5528213069559124 TIQGDEEDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIQGDEEDLR 10 0 P54920;M0R0Y2;M0R213 P54920 NAPA Alpha-soluble NSF attachment protein 0 2191270.0 433340.0 783740.0 974190.0 False True 568112.9364705295 666809.0469945922 873390.1638903378 1.0 1.1737262156662445 1.5373530645444902 19.11581822932521 -6.959145224327303 0.4473181608632615 0.9879469888166288 1.7374832203132162 0.9997371691806276 0.0036297653768996812 0.08000789447963748 0.022270325521972365 0.004841284930383993 0.030090349927529004 1.0986384028001734e-07 6.959145224327303 0.7495362314965874 TIQGHLQSENFK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIQGHLQSENFKQR 14 1 E7ET15;O15042-2;O15042;O15042-3 E7ET15 U2SURP U2 snRNP-associated SURP motif-containing protein 1 6426600.0 1800000.0 1864700.0 2761900.0 True False 1496779.7535205348 1854654.490986031 3339400.5204172386 1.0 1.2390964579950716 2.231056715300114 20.513430518255305 -6.94403611048694 0.6208786696643471 0.9891496220714935 2.533635253833761 0.9986462096712122 0.01961057446237508 0.08597259625970258 0.04658009749251177 0.019733536834946785 0.08397784810517535 1.137532698926415e-07 6.94403611048694 1.5444856317622675 up TIQVDNTDAEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIQVDNTDAEGR 12 0 P28838-2;P28838 P28838-2 LAP3 Cytosol aminopeptidase 0 6792300.0 1543700.0 1412900.0 3835700.0 False True 1494696.0884786593 1977078.3381761617 2831015.101466548 1.0 1.3227293182980653 1.8940406168775281 20.51142074524178 -6.962359171823288 0.400801025531411 0.9688704214030056 2.2687873072348435 0.9998479377625492 0.004558446102769338 0.07886889466222365 0.01809466659011267 0.0073504173928362155 0.04785230760127965 1.0905380625908721e-07 6.962359171823288 1.2999168858318377 TIQVDNTDAEGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIQVDNTDAEGR 12 0 P28838-2;P28838 P28838-2 LAP3 Cytosol aminopeptidase 0 27413500.0 3039700.0 21519000.0 2854800.0 False True 4611447.131836775 17678766.32128562 2290547.5286967093 1.0 3.8336699556271463 0.4967090510228547 22.136788127420335 -6.681709526123606 1.8956750395488782 2.7901352945255735 0.5091984985952649 0.33199811616798747 1.2005303376614658 0.43475368233196243 3.0220186152416084 0.5078757237239402 1.336629438323111 2.081088138414289e-07 6.681709526123606 -2.280936795930309 TIQVDNTDAEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIQVDNTDAEGR 12 0 P28838-2;P28838 P28838-2 LAP3 Cytosol aminopeptidase 0 3586770.0 1543700.0 1239200.0 803870.0 False True 1283654.947505361 1232524.1836380593 971955.5003250686 1.0 0.9601678286157285 0.7571781670876234 20.291826020676055 -6.939381392790975 0.665294292191407 1.0023045920898277 0.7034204203447416 0.9980817325689828 0.00465702326783784 0.08805002311483677 0.05590351546094812 0.004512286417582987 0.017519078576582026 1.1497902119213259e-07 6.939381392790975 -0.2988841717450861 TIQVDNTDAEGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIQVDNTDAEGR 12 0 P28838-2;P28838 P28838-2 LAP3 Cytosol aminopeptidase 0 6171000.0 3039700.0 0.0 3131300.0 False True 3934951.5714448877 0.0 2561435.5298512154 1.0 0.0 0.6509446135090993 21.907914449512784 -10.305079411810894 7.530390399161146 1.000003944359212 0.3254723067545497 0.5887640610614215 0.2657470256517498 1.7598298503994072e-05 1.6237392026249148e-06 0.2573099567913737 0.08576948372111516 4.9535960480476006e-11 10.305079411810894 -0.6745316376046622 TISHVIIGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TISHVIIGLK 10 0 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 0 39462900.0 14091900.0 17026000.0 8345000.0 False True 18474617.36615372 14485787.166828204 7481539.450892403 1.0 0.784091322690492 0.4049631612180991 24.13904114876326 -6.962507559333625 0.3985215761787642 1.0211840571428787 0.15406001587969023 0.9998521929066728 0.0029901572585621238 0.07881723439791594 0.017908599725819957 0.0048793872764706205 0.031782418446256115 1.0901655167892757e-07 6.962507559333625 -0.8671240412631885 down TISHVIIGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TISHVIIGLK 10 0 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 0 56248900.0 29834900.0 10476000.0 15938000.0 False True 28887807.430298615 14659121.431618283 11763359.670248916 1.0 0.5074501229277528 0.4072084632463682 24.783957372458996 -13.999999999999986 0.22379266508246387 4.022643846415554 0.35549946861009885 0.9995019743147149 0.005781530874034363 13.105606815335703 0.1498347324361679 17.54203738186728 0.054120901502506646 1.0000000000000327e-14 13.999999999999986 -3.6671443778054553 TISHVIIGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TISHVIIGLK 10 0 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 0 70590000.0 28422000.0 0.0 42168000.0 False True 43118251.92652713 0.0 33833476.31710902 1.0 0.0 0.7846671607828807 25.36179535463843 -10.828319585595498 9.304569824641206 1.0153551065369095 0.39233358039144034 0.4443354408460348 0.3203390269727442 0.09439973559593727 0.0017417851644887525 0.2869493467784501 0.10338897638381056 1.48484258455149e-11 10.828319585595498 -0.6230215261454692 TISHVIIGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TISHVIIGLK 10 0 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 0 30313300.0 14091900.0 16221400.0 0.0 False True 19302056.24927839 15504684.911003584 0.0 1.0 0.8032659687012998 0.0 24.20225121028615 -7.245644173717219 0.8563407213300459 0.9893636305728807 1.3027208304993512e-16 0.9888695151261712 0.045635115520868366 0.09791145773015836 0.1383031104160617 0.03865200468874584 0.068038827696123 5.6800979676608817e-08 7.245644173717219 -0.9893636305728806 down TISHVIIGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TISHVIIGLK 10 0 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 0 49539100.0 29834900.0 13680300.0 6023900.0 False True 24809041.26017213 13606601.508573068 7283469.638633331 1.0 0.5484533386792659 0.29358126185738775 24.564362647893272 -9.044045489225757 0.18846563406943606 1.427298402053662 8.231798786685591e-20 0.9996510945025157 0.0054560650303423315 0.5027619860810683 0.0627098127218677 0.2742734011161555 0.14591346876272376 9.035548278911706e-10 9.044045489225757 -1.427298402053662 down TISHVIIGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TISHVIIGLK 10 0 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 0 82232000.0 28422000.0 53810000.0 0.0 False True 36792839.28137854 50815426.19720846 0.0 1.0 1.3811227181623622 0.0 25.13292167673088 -6.862088030537492 1.3789418103621416 1.2009535925056956 7.418265609197283e-21 0.9110290347520695 0.17371960590150948 0.16359605170170433 0.6254184216933569 0.10164653251034719 0.2115596201600048 1.3737634879477723e-07 6.862088030537492 -1.2009535925056956 down TISLDYKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 TISLDYKK 8 1 Q8N3C0;Q8N3C0-4 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 1 7546700.0 2656300.0 3333700.0 1556700.0 True False 3482435.02364579 2836324.9546608203 1395627.616920815 1.0 0.8144660088134102 0.400761997695429 21.731665004149693 -6.957863193268909 0.4645691214153023 1.0115239736986348 0.18689840126417234 0.999682556324145 0.004462777701030477 0.08047343410833299 0.024019817241518082 0.005663487193110957 0.03416041542269224 1.1018863591506133e-07 6.957863193268909 -0.8246255724344624 down TISLDYKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 TISLDYKK 8 1 Q8N3C0;Q8N3C0-4 Q8N3C0 ASCC3 Activating signal cointegrator 1 complex subunit 3 1 15741800.0 3653500.0 7087200.0 5001100.0 True False 5542626.606627512 5822433.787453657 4012630.39294 1.0 1.0504827766120073 0.7239582742488838 22.40213838934098 -6.867423687069122 1.147563082858753 1.0281542610061143 0.7057429209640673 0.9620475306239766 0.027958479924756915 0.13935306475741507 0.3445879381655706 0.01893515495731714 0.04464231865832595 1.3569889554029767e-07 6.867423687069122 -0.32241134004204697 TISVILFLNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TISVILFLNK 10 0 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A0A0MR13;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 0 5314050.0 3370900.0 1025100.0 918050.0 False True 3263892.6246373723 1434427.775825879 677585.1640903521 1.0 0.43948375170131343 0.207600323299739 21.638162165711016 -10.547412356897944 0.19051641188332072 1.8192344861595522 1.1499872646505288e-23 0.9994442826251464 0.007841544796094432 2.32115554495706 0.098613242512925 1.040713429651367 0.1504846749423536 2.835225740476562e-11 10.547412356897944 -1.8192344861595522 TISVILFLNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TISVILFLNK 10 0 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A0A0MR13;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 0 73172000.0 18972000.0 29446000.0 24754000.0 False True 28781911.03898646 24191131.23735192 19861361.049936365 1.0 0.8404977419527109 0.6900640135755132 24.77865905041541 -6.971833235713545 0.20983052577750605 1.0789312871728662 0.4474317324088591 0.9999933681350421 0.0003258427126564641 0.07571221504409141 0.006859280070900806 0.004510863913067169 0.01559470048001087 1.0670057610091698e-07 6.971833235713545 -0.6314995547640072 TISVILFLNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TISVILFLNK 10 0 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A0A0MR13;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 0 6135450.0 3370900.0 950050.0 1814500.0 False True 2803052.7061902056 944931.8920798406 2193903.560699909 1.0 0.3371081428447891 0.7826836633699167 21.418567441145292 -10.557556441117631 5.610046032693637 1.001450195920814 0.5598959031076424 0.5653665217645596 0.18190544452693005 0.003309148084370093 0.00026097991991596024 0.17664728556238543 0.05870972976977133 2.76976905526732e-11 10.557556441117631 -0.4415542928131716 TISVILFLNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TISVILFLNK 10 0 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A0A0MR13;P63092-2;Q5JWF2-2;A0A590UJB0;P63092-3;A0A590UJF0 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 0 53427000.0 18972000.0 16268000.0 18187000.0 False True 24559627.994029768 15362671.499278698 14877152.614378687 1.0 0.6255254152470563 0.605756431571162 24.54978537250786 TISVQFNQLFLRPNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TISVQFNQLFLRPNK 15 1 H0YBS1;Q75QN2-2;Q75QN2;J3KNV5 H0YBS1 INTS8 Integrator complex subunit 8 0 9365400.0 2271400.0 3419500.0 3674500.0 False True 2977827.396268892 2909323.9291066 3294297.9882928915 1.0 0.9769954876336606 1.1062756667564162 21.50582870277287 -6.860904094395882 1.1810634347315516 0.9874863646539755 1.1126478572318472 0.9547361134051342 0.011980072820879787 0.14587847041545907 0.38613753568974046 0.00790808743905178 0.01848020416469351 1.3775136327656716e-07 6.860904094395882 0.12516149257787168 TISVQFNQLFLRPNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TISVQFNQLFLRPNK 15 1 H0YBS1;Q75QN2-2;Q75QN2;J3KNV5 H0YBS1 INTS8 Integrator complex subunit 8 0 12579700.0 2271400.0 3228800.0 7079500.0 False True 3111197.96227698 3086140.939786231 5407467.906879235 1.0 0.9919461818905249 1.7380661637235368 21.56903876429576 -6.904462326788352 0.9326445099985544 0.9726610619993495 1.8238806947659059 0.9886579395604533 0.03725780588652478 0.1081946366824658 0.1594825902576228 0.029691679321174252 0.07913253556585134 1.2460563227047902e-07 6.904462326788352 0.8512196327665563 TISVQFNQLFLRPNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TISVQFNQLFLRPNK 15 1 H0YBS1;Q75QN2-2;Q75QN2;J3KNV5 H0YBS1 INTS8 Integrator complex subunit 8 0 8565700.0 3026200.0 2775800.0 2763700.0 False True 2516419.3833910204 2760846.2144468403 3341576.8920949786 1.0 1.0971327882264366 1.3279093755795233 21.262940949378358 -6.956543549008385 0.4816840258835963 0.9945475538116872 1.4401436966361678 0.9996197405329118 0.0026817571069104656 0.0809597609978673 0.025875252216043046 0.0032650803962825338 0.01903607317119715 1.1052396355926974e-07 6.956543549008385 0.44559614282448057 TITDVINIGIGGSDLGPLMVTEALKPYSSGGPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TITDVINIGIGGSDLGPLMVTEALKPYSSGGPR 33 1 P06744;A0A2U3TZU2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;K7ENA0;A0A0J9YXM3 P06744 GPI Glucose-6-phosphate isomerase 0 48376700.0 17797000.0 21245000.0 9334700.0 False True 26999350.13498008 17453663.762057375 7489692.453455652 1.0 0.6464475505817671 0.2774026936208396 24.686421346734875 -7.409074776439043 0.31384082596564056 1.0738778378778921 1.3619264219204506e-15 0.9997337502589605 0.004813913333753978 0.11652090418208443 0.02819347000391481 0.01753362361961943 0.05830545740507057 3.898748525905348e-08 7.409074776439043 -1.0738778378778908 down TITGFQTHTTPVLLAHGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TITGFQTHTTPVLLAHGER 19 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 30761300.0 8705300.0 10237000.0 11819000.0 False True 11412732.602245105 8709679.50351346 10596083.255853496 1.0 0.7631546104742782 0.9284440129412164 23.444140928205115 -10.017358321831018 5.178425114580531 1.0000012576215698 0.8457993118546985 0.5371305512023136 0.06747911599117137 9.797891702870027e-07 1.8594342142408643e-07 0.06533690662651773 0.021778791037226755 9.608192115118831e-11 10.017358321831018 -0.1542019457668713 TITGFQTHTTPVLLAHGER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TITGFQTHTTPVLLAHGER 19 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 27606300.0 6951600.0 5418700.0 15236000.0 False True 6730925.263113452 7582415.1681471905 11245234.529797515 1.0 1.1265041389926047 1.670681829053013 22.68237340710959 -6.943208401254786 0.6290140847892622 0.9940638634672291 1.8324004383976176 0.9985545917920257 0.011062066402310682 0.08633308628979575 0.04817105612911478 0.011050488100664767 0.04621530475189166 1.1397027567079574e-07 6.943208401254786 0.8383365749303885 TITGFQTHTTPVLLAHGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TITGFQTHTTPVLLAHGER 19 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 77346800.0 16424000.0 52306000.0 8616800.0 False True 24916408.755234737 42971585.63135666 6913685.703122393 1.0 1.7246299839389443 0.2774752080461789 24.570592809444484 -6.770589896523569 1.572361559971552 1.4153291866121964 0.2691940061118153 0.7327119611923145 0.30544236401340874 0.26549983169452157 1.2955386393209107 0.1531149075619841 0.36425547196573804 1.695938516157659e-07 6.770589896523569 -1.146135180500381 TITGFQTHTTPVLLAHGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TITGFQTHTTPVLLAHGER 19 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 32064300.0 8705300.0 10769000.0 12590000.0 False True 11923884.661886826 10293189.971679224 9616501.299189143 1.0 0.8632413230715063 0.8064906338726221 23.507350989728007 -13.99999999999878 0.12069760239951989 1.6514918863437682 0.7167586799872218 0.9996895211017528 0.001431109200627824 11.961165436508365 0.10701018956190562 1.8674833373845732 0.07963139319027823 1.00000000000281e-14 13.99999999999878 -0.9347332063565464 TITGFQTHTTPVLLAHGER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TITGFQTHTTPVLLAHGER 19 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 17549400.0 6951600.0 5643500.0 4954300.0 False True 5780563.4080962995 5613097.345352961 5990221.223904965 1.0 0.9710294566600922 1.0362694431333488 22.462778682543867 -6.7859515301609745 1.5121647615804834 0.983723328124334 1.0368910665581512 0.7880707664328084 0.012286770082310482 0.24142016694270818 1.0905546217728055 0.0063967822592751935 0.015023728416153766 1.6369992100503346e-07 6.7859515301609745 0.05316773843381717 TITGK(ub)TFSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TITGKTFSSR 10 1 O15144 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 1 1267720.0 458980.0 584680.0 224060.0 True False 628677.309468119 558846.9043217953 171141.64266054952 1.0 0.8889248838877254 0.27222493969973366 19.26196016803105 -6.937498653926201 0.6824379716465445 1.007312789119727 0.1174844489504274 0.9978175619272948 0.014955083848470484 0.0889265704216757 0.059946745244672965 0.014295241384416365 0.05368925267804877 1.1547855638834083e-07 6.937498653926201 -0.8898283401692997 down TITK(ub)QVPNESFFNFFNPLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TITKQVPNESFFNFFNPLK 19 1 Q99733;Q99733-2;H0YCI4 Q99733 NAP1L4 Nucleosome assembly protein 1-like 4 1 8566900.0 3256000.0 2669800.0 2641100.0 True False 3152640.0622442923 3735865.0628230767 1949316.6786983588 1.0 1.1849957461251064 0.6183124746916668 21.58812903587024 -6.818797741413369 1.3772446359517083 1.0998320383086408 0.6062741331011682 0.8815611836885825 0.08120100781770374 0.19504614748980556 0.7273108198984918 0.04633748764838499 0.1068270236396831 1.5177570490696813e-07 6.818797741413369 -0.49355790520747267 TITLEVEPSDTIENVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TITLEVEPSDTIENVK 16 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 101190000.0 20981000.0 37151000.0 43058000.0 False True 27506294.18029301 31608215.613463797 38602771.201500975 1.0 1.1491266473878414 1.4034159217695736 24.713258448073383 -6.9630396160966885 0.39024245201653207 0.9844246018656425 1.5772583173437533 0.9998668490119067 0.001921814477477621 0.07863271307196237 0.017246245727840868 0.0032827163559214913 0.021388148781857866 1.0888307662773528e-07 6.9630396160966885 0.5928337154781108 TITLEVEPSDTIENVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TITLEVEPSDTIENVK 16 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 154674000.0 38998000.0 39157000.0 76519000.0 False True 37760029.836425915 54792594.301057406 56476378.37920547 1.0 1.4510739143590587 1.4956656184822312 25.170356568870154 -11.80393066910349 0.374077064344129 5.063496784237203e-17 1.5005279499618023 0.9996448554529273 0.00421926519704074 4.81423132331518 0.19220363775570903 3.815902384279359 0.01229550771155596 1.5706135175165672e-12 11.80393066910349 1.5005279499618023 TITLEVEPSDTIENVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TITLEVEPSDTIENVK 16 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 436181000.0 38101000.0 326440000.0 71640000.0 False True 57802002.55621046 268184231.51263884 57480322.59907261 1.0 4.63970484849273 0.9944347956314312 25.784616140118583 -6.646521702809578 2.0209391593332855 3.368263182642778 1.0097163242416283 0.18009380671196362 1.5547990655316477 0.5170917180143134 4.043940671434889 0.6248073268991179 1.7219309509059877 2.2567232184298184e-07 6.646521702809578 -2.3585468584011497 TITLEVEPSDTIENVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TITLEVEPSDTIENVK 16 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 128057000.0 20981000.0 41683000.0 65393000.0 False True 28738242.690205704 39841307.2327519 49948520.21111006 1.0 1.3863515477350408 1.738050609062921 24.776468509596274 -6.972245788414798 0.19730548741242793 0.783241779116279 2.350842619001163 0.9999950090393716 0.0006733581637973513 0.07558051764612254 0.00634974495817437 0.011675807886585505 0.037595678948449895 1.065992653281487e-07 6.972245788414798 1.567600839884884 TITLEVEPSDTIENVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TITLEVEPSDTIENVK 16 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 114736000.0 38998000.0 31897000.0 43841000.0 False True 32428564.904329862 31725164.529941227 53007950.402118936 1.0 0.9783092351923746 1.634606728928708 24.95076184430443 -6.899259080129944 0.965968831709859 0.972155145888487 1.7024618010207395 0.9861928856975184 0.035767869229858466 0.11195255349352942 0.1805256213150524 0.027810108621336056 0.07208964878419405 1.261075010753578e-07 6.899259080129944 0.7303066551322526 TITLEVEPSDTIENVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TITLEVEPSDTIENVK 16 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 141584000.0 38101000.0 58051000.0 45432000.0 False True 49322495.582992285 54820410.81906987 37163842.17168598 1.0 1.1114687156659895 0.7534866541607247 25.555742462211033 -6.823053345764802 1.3586670456417622 1.0599015513187693 0.7451510908153848 0.8912552624515009 0.049323464389168487 0.18954013101227846 0.6866672691358302 0.028521906213278155 0.06568921309244913 1.5029573417474057e-07 6.823053345764802 -0.3147504605033845 TITLEVEPSDTIENVK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TITLEVEPSDTIENVKAK 18 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 11156535800.0 2001224000.0 4422562600.0 4732749200.0 True False 2623624043.880782 3762733499.0940003 4243049712.5200105 1.0 1.434174041768684 1.6172476092435197 31.288913855615952 -11.488058359704487 0.1536760770027799 1.4523380412619485e-19 1.8426998218607817 0.9996008655525321 0.005171339961557972 4.2066700406679205 0.09677076035464628 1.5805907744418686 0.16916876898937921 3.2504361567925534e-12 11.488058359704487 1.8426998218607817 TITLEVEPSDTIENVK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TITLEVEPSDTIENVKAK 18 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 19903777300.0 3824673300.0 5718898100.0 10360205900.0 True False 3703261139.611821 8002483934.989612 7646557175.275105 1.0 2.160928876819213 2.0648171670865816 31.78614914034143 -10.481710324169875 6.371076674499728 0.9994448857961705 2.1128730219528973 0.9944371163652449 0.03923744119190579 0.00030951759433458213 2.517939578613124e-05 0.03800790295744264 0.012663829690336978 3.298296362630202e-11 10.481710324169875 1.1134281361567266 TITLEVEPSDTIENVK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TITLEVEPSDTIENVKAK 18 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 67788382700.0 17829185800.0 26998692800.0 22960504100.0 True False 27048178346.677197 22180565128.090424 18422350400.688545 1.0 0.8200391480639306 0.6810939415057387 34.654812382899394 -6.974010663672282 0.13068278805666092 1.213063863830546 0.2844712686043774 0.9999992007912669 0.0001165679715285152 0.07502147800134948 0.003925512347097637 0.00867677747354918 0.018917520000211185 1.0616694886324329e-07 6.974010663672282 -0.9285925952261687 TITLEVEPSDTIENVK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TITLEVEPSDTIENVKAK 18 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 11099799900.0 2001224000.0 2952506900.0 6146069000.0 True False 2741130593.8451076 2822055382.523327 4694494084.464357 1.0 1.0295224127080727 1.7126123414204717 31.352123917138844 -6.915965690383314 0.8541096089783382 0.9826273617139251 1.8131569464568054 0.9929849197895403 0.02757173640780741 0.10060426054219974 0.11834381038961496 0.023261602564366612 0.06720513474420306 1.2134847129559051e-07 6.915965690383314 0.8305295847428803 TITLEVEPSDTIENVK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TITLEVEPSDTIENVKAK 18 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 15303698300.0 3824673300.0 5898687500.0 5580337500.0 True False 3180385310.7058744 5866910099.6397295 6747160270.684615 1.0 1.8447167643148217 2.121491458274629 31.566554415775705 -10.548560216330683 0.2366584123734769 6.994076678704168e-17 2.2829448983727736 0.9992116023482831 0.01339383901143356 2.239055200846375 0.11913047239879589 1.4504619338005253 0.1353919777352455 2.8277420083149347e-11 10.548560216330683 2.2829448983727736 TITLEVEPSDTIENVK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TITLEVEPSDTIENVKAK 18 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 61602896800.0 17829185800.0 27250271000.0 16523440000.0 True False 23080232483.894127 25733769463.936672 13516343464.811623 1.0 1.1149701148761928 0.5856242338218912 34.42593870499185 -6.849824350494902 1.2359110636064254 1.0613431618230427 0.5645311776040849 0.9400557467098859 0.05565969816202029 0.1576475154965833 0.46347006213702596 0.035241610157212916 0.08154342956889288 1.413108958057293e-07 6.849824350494902 -0.4968119842189578 TITLEVEPSDTIENVK(ub)AK(ub)IQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TITLEVEPSDTIENVKAKIQDK 22 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 18142100.0 5625500.0 8500500.0 4016100.0 True False 7375084.977419494 7232258.534689483 3600552.497151468 1.0 0.9806339258235931 0.48820488281496166 22.814228241844713 -6.915193047671919 0.8596127776605285 1.0128585599544009 0.41695540158853944 0.9927382832736805 0.020181627264422845 0.10108357716463445 0.12087827386422292 0.016959541074462414 0.04868547733829448 1.2156455155325453e-07 6.915193047671919 -0.5959031583658614 down TITLEVEPSDTIENVK(ub)AK(ub)IQDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TITLEVEPSDTIENVKAKIQDK 22 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 185714100.0 23177100.0 36959000.0 125578000.0 True False 22441355.647003107 51716921.43863884 92685354.54075295 1.0 2.3045364216018425 4.130113884324562 24.419656493729295 -6.966385123922272 0.3334255206509176 0.786285461963272 5.708435090703528 0.9999389162116576 0.010033301772340426 0.07749401240380566 0.013219501551306356 0.026322678244451406 0.1587989312901094 1.0804753817304382e-07 6.966385123922272 4.9221496287402555 TITLEVEPSDTIENVK(ub)AK(ub)IQDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TITLEVEPSDTIENVKAKIQDK 22 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 1313309000.0 133549000.0 584890000.0 594870000.0 True False 202603596.73970082 480511809.7335723 477293683.75921625 1.0 2.3716844985280288 2.3558006444102233 27.594084545046787 -10.044302717492062 5.4204822178132535 0.9999909969121668 2.3637425714704414 0.9998982664013303 0.006484556294190599 7.055283244267945e-07 1.2441381220064117e-07 0.006278685996953888 0.002092881543910111 9.03019819883498e-11 10.044302717492062 1.3637515745582747 TITLEVEPSDTIENVK(ub)AK(ub)IQDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TITLEVEPSDTIENVKAKIQDK 22 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 223797600.0 23177100.0 60412500.0 140208000.0 True False 19272785.56962264 60087045.87155764 169524844.55145398 1.0 3.11771464765662 8.796073818133248 24.20006176916357 -6.95394422111282 0.5137238200393087 0.8986127541891653 11.265879901304348 0.9994755521245452 0.07537864955156305 0.08193959231996174 0.029699257326186005 0.08627363491478467 0.4687749856662632 1.1118745224207558e-07 6.95394422111282 10.367267147115182 TITLEVEPSDTIENVK(ub)AK(ub)IQDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TITLEVEPSDTIENVKAKIQDK 22 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 947805000.0 133549000.0 471886000.0 342370000.0 True False 172881813.14435393 445625129.2788681 280062173.01285696 1.0 2.5776287347633104 1.619963187099437 27.365210867139236 -10.14861030278561 6.6728782128940285 0.9999977107291006 2.0987959609313744 0.6370597951169938 0.3909653226699174 1.3315378832420444e-05 1.698292687618831e-06 0.3785513351550352 0.12618351530376626 7.102147656473238e-11 10.14861030278561 1.098798250202274 TITLEVEPSDTIENVKAK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 TITLEVEPSDTIENVKAK 18 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 2386400.0 0.0 1074500.0 1311900.0 True False 0.0 914188.7883681946 1176157.1726334032 0.0 TITLEVEPSDTIENVKAKIQDK(ub)EGIPPDQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TITLEVEPSDTIENVKAKIQDKEGIPPDQQR 31 3 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 85818000.0 22316000.0 35906000.0 27596000.0 True False 28888501.91412446 33907799.536089346 22573811.158871397 1.0 1.1737472450764503 0.7814116227271163 24.78399205547641 -6.786293840354397 1.5108892662800837 1.0975750134449516 0.7776412322185239 0.7891837549445746 0.07370171944087996 0.24090819651952694 1.0864232565673206 0.038402966191948676 0.0901678628851776 1.6357094383411255e-07 6.786293840354397 -0.3199337812264277 TITLNVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TITLNVYK 8 0 Q2KHT3-2;Q2KHT3 Q2KHT3-2 CLEC16A Protein CLEC16A 0 68386000.0 20383000.0 20913000.0 27090000.0 False True 26722310.38925277 17792861.918235537 24286986.665629163 1.0 0.6658429476738472 0.9088655251679492 24.671541411657522 -10.466512861219845 5.235205797137263 1.0003425640411814 0.7873542364208952 0.5051570088601005 0.09921355180609943 0.00039731954971217875 4.048837624918004e-05 0.09621621795574126 0.03202103615525761 3.415758350913582e-11 10.466512861219845 -0.2129883276202862 TITLNVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TITLNVYK 8 0 Q2KHT3-2;Q2KHT3 Q2KHT3-2 CLEC16A Protein CLEC16A 0 36859000.0 13686000.0 4598000.0 18575000.0 False True 13251545.421337634 6434005.378253236 13709650.261944648 1.0 0.48552868165045887 1.0345699181522914 23.659657283637284 -11.811994067340343 13.923917959983763 0.9082922976979368 0.7840443699111848 0.0 0.25723627312004677 0.0 0.0 0.0 0.07465750593521701 1.5417215134210437e-12 11.811994067340343 -0.12424792778675209 TITLNVYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TITLNVYK 8 0 Q2KHT3-2;Q2KHT3 Q2KHT3-2 CLEC16A Protein CLEC16A 0 53959600.0 13689000.0 30644000.0 9626600.0 False True 20767213.7999518 25175338.777335215 7723898.290511336 1.0 1.2122636680994563 0.3719275182946912 24.30780433650269 -6.83975438692278 1.2834023117201583 1.1129308830376021 0.3444009622461996 0.9240436969145787 0.09833209800668635 0.16909342190310392 0.5411083864736433 0.060078254443890186 0.13840990777963486 1.446257463195039e-07 6.83975438692278 -0.7685299207914025 down TITLNVYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TITLNVYK 8 0 Q2KHT3-2;Q2KHT3 Q2KHT3-2 CLEC16A Protein CLEC16A 0 22211500.0 13686000.0 7879200.0 646300.0 False True 11380515.39260112 7836753.185701258 781438.3418464331 1.0 0.6886114481947111 0.06866458283202834 23.44006255907156 -7.400525688399535 0.6268736644788173 0.9989647313942375 1.160025776531205e-20 0.9942801005413644 0.029277083578705624 0.10943329827868369 0.09137034523179141 0.02718430387140768 0.06763418419487177 3.976255763351436e-08 7.400525688399535 -0.9989647313942375 down TITSALK(ub)QYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TITSALKQYLR 11 1 A1A4S6;H0Y8W5 A1A4S6 ARHGAP10 Rho GTPase-activating protein 10 1 8349000.0 3728400.0 3555100.0 1065500.0 True False 3100329.7961255303 3535947.9706679014 1288291.1236846265 1.0 1.1405070438270024 0.4155335749424461 21.5639902589939 -6.856441167183259 1.2034891433409534 1.0756296924063873 0.38272371630879154 0.949174203860527 0.0707726492896016 0.15051666542700443 0.4162808967095037 0.0459256690084655 0.10681727140645342 1.391742318020441e-07 6.856441167183259 -0.6929059760975957 down TITSALK(ub)TYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TITSALKTYLR 11 1 A0A2R8YDK5;H0Y835;H0Y4P9;A0A2R8YGB3;Q9UNA1-2;Q9UNA1 A0A2R8YDK5 ARHGAP26 Rho GTPase-activating protein 26 1 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 TITVALADGGRPDNTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TITVALADGGRPDNTGR 17 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 105777300.0 31091400.0 32639900.0 42046000.0 False True 40761126.48954595 27770154.149333727 37695483.25371142 1.0 0.6812901541486094 0.9247900266784633 25.280690587119196 -9.793774106303896 5.618516557281778 1.0000000328987622 0.8030400917584711 0.4659153547877063 0.09940840669519502 33229728.09064774 57923546.96368629 8.729666959481476 0.0340301449536653 1.6077773039767497e-10 9.793774106303896 -0.19695994114029103 TITVALADGGRPDNTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TITVALADGGRPDNTGR 17 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 55918800.0 18574700.0 10748000.0 26596100.0 False True 17985056.315776736 15039732.450079551 19629783.544102598 1.0 0.836234937829274 1.0914496568400003 24.100295341136295 -6.7334191426723615 1.7108224677427184 0.9018234068551958 1.091393322513604 0.5750088622282002 0.06882640058029768 0.3298697163764105 1.8930120317597732 0.03186130077362838 0.07875568047341246 1.847484729219262e-07 6.7334191426723615 0.1895699156584083 TITVALADGGRPDNTGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TITVALADGGRPDNTGR 17 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 138536500.0 28444100.0 81657000.0 28435400.0 False True 43151779.242253624 67084670.360947 22815130.726321418 1.0 1.5546211891828232 0.5287181925509379 25.36291671031462 -6.759890105395814 1.6130240473954733 1.3222006538990636 0.5250079976735335 0.6904700126088825 0.2332701538876114 0.2830994505852753 1.4517308653634993 0.1141083446600892 0.2742347413932657 1.738240620426532e-07 6.759890105395814 -0.7971926562255301 TITVALADGGRPDNTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TITVALADGGRPDNTGR 17 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 105712800.0 31091400.0 23387300.0 51234100.0 False True 42586730.793492354 22353971.75454113 39133660.77941116 1.0 0.5249046202428157 0.9189167623402344 25.343900648642087 -10.027417348588909 7.15428658802311 1.0000000306231087 0.7219106912915253 0.3991047413987171 0.16085478343327622 7.86918308787603e-08 1.0705018694545224e-08 0.15574699059435598 0.05191565811623993 9.388206884274517e-11 10.027417348588909 -0.2780893393315834 TITVALADGGRPDNTGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TITVALADGGRPDNTGR 17 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 42724600.0 18574700.0 14223200.0 9926700.0 False True 15445686.048732152 14146576.79851585 12002327.074125 1.0 0.9158917741745154 0.7770666214667883 23.88070061657057 -6.963619149220021 0.3810099083430704 1.0094283293778707 0.6786129847114227 0.9998817844204512 0.0009994171142840582 0.07843273390552813 0.016531831849214373 0.001804840357172568 0.011724951193097867 1.0873787730138698e-07 6.963619149220021 -0.330815344666448 TITVALADGGRPDNTGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TITVALADGGRPDNTGR 17 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 95825400.0 28444100.0 40043900.0 27337400.0 False True 36821448.16703474 37815421.76358289 22362273.70541134 1.0 1.026994418906045 0.6073165184587088 25.13404303240707 -6.891547634228979 1.0131485155508977 1.0217202025120056 0.5701018400684382 0.9818716837537848 0.025823189179658132 0.11789777873816194 0.21456842207641938 0.019379536109375588 0.048592223660839505 1.283666967763079e-07 6.891547634228979 -0.45161836244356734 TITVK(ub)GNVETCAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TITVKGNVETCAK 13 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 3072260.0 1257200.0 873200.0 941860.0 True False 1722020.814552531 834619.1367137432 719412.0662155909 1.0 0.48467424415576527 0.4177719921478016 20.71567115042724 -13.999999999999998 0.28779971200739113 5.385963467004776 0.3991333422263275 0.9996225404443719 0.005053957559233543 15.836263831398222 0.17007932628364056 41.070202814401604 0.025521006929030466 1.0000000000000041e-14 13.999999999999998 -4.986830124778448 TITVK(ub)GNVETCAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TITVKGNVETCAK 13 1 O00425 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 1 3460520.0 977690.0 1490000.0 992830.0 True False 812992.5540108291 1481973.074258158 1200426.162672742 1.0 1.8228618047569696 1.4765524687164016 19.632882613525744 -10.33352743703874 5.62929602859471 0.9998849341935876 1.6497071367366911 0.8243440395772582 0.14138019441025676 0.0002042052809391502 2.417628661655689e-05 0.13691471758215792 0.04563026153620478 4.63951478403637e-11 10.33352743703874 0.6498222025431035 TITYQAVPSEVPNEEPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TITYQAVPSEVPNEEPK 17 0 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;Q9BY44-2;H7C5R5 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 7121700.0 2365500.0 1245800.0 3510400.0 False True 2290408.497309233 1743254.4367611753 2590920.9302573637 1.0 0.7611107096437805 1.131204731951166 21.127173497115656 -6.732433739112287 1.7142855604292697 0.8566268823831459 1.131086326911586 0.5705035489980906 0.1004059198948548 0.33171447017811034 1.910856274404013 0.046392989898069795 0.1148083339645231 1.8516813861507102e-07 6.732433739112287 0.2744594445284402 TIVINYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIVINYAK 8 0 P41214;P41214-2 P41214 EIF2D Eukaryotic translation initiation factor 2D 0 6185500.0 1701700.0 1577500.0 2906300.0 False True 2230945.1792862434 1342143.1490468385 2605583.9551981557 1.0 0.6016029266466496 1.1679282751500744 21.08922363219193 -6.717666100480662 1.7677958910941785 0.7570146599733206 1.1669261481803932 0.5014212448607034 0.16769707466772377 0.35988334870634264 2.1967067971225895 0.07536070812052693 0.18969895703162953 1.915728232245189e-07 6.717666100480662 0.40991148820707257 TIVINYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIVINYAK 8 0 P41214;P41214-2 P41214 EIF2D Eukaryotic translation initiation factor 2D 0 3076110.0 992450.0 704460.0 1379200.0 False True 960945.2179896645 985754.5517103685 1017946.144886894 1.0 1.0258176358612887 1.0593175613241281 19.874094661952597 -6.967555523785393 0.31110818138916807 0.9949061293905569 1.0912956051602771 0.9999564774320462 0.00016010077218572822 0.07710431389033534 0.011856532609679258 0.0005274026955337148 0.002970970221117346 1.0775674797810673e-07 6.967555523785393 0.09638947576972023 TIVINYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIVINYAK 8 0 P41214;P41214-2 P41214 EIF2D Eukaryotic translation initiation factor 2D 0 4408700.0 1701700.0 1169400.0 1537600.0 False True 2330864.476713365 1117732.0413113292 1174450.5478660248 1.0 0.47953540520184473 0.5038690835951383 21.152433693714823 -10.359459187247408 5.8035637273420235 1.0000974313601316 0.49170224439849575 0.998284089218436 0.00993418260476374 1.2525926008221621e-05 1.382481758779318e-06 0.00962055821807473 0.0032062436488688338 4.370597497589621e-11 10.359459187247408 -0.5083951869616359 TIVINYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIVINYAK 8 0 P41214;P41214-2 P41214 EIF2D Eukaryotic translation initiation factor 2D 0 2419110.0 992450.0 887800.0 538860.0 False True 825266.147989697 883017.245185498 651533.1345928652 1.0 1.0699787545344972 0.7894824429427575 19.654499937386873 -6.8406665714651504 1.279467659768512 1.037222540316391 0.7801442834881825 0.9255655219461048 0.03252287599099612 0.1680239882059672 0.5340485683341067 0.019930611855931746 0.045920342810545446 1.4432229572137047e-07 6.8406665714651504 -0.2570782568282085 TIVITSHPGQIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIVITSHPGQIVK 13 0 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 89960100.0 25251000.0 20862000.0 43847100.0 False True 33104305.531031825 17749470.91943908 39310222.70308266 1.0 0.5361680492829191 1.187465559917378 24.98051552971272 -6.715465228590339 1.775614741728604 0.7164530219065981 1.1862026300273338 0.49104917018172545 0.1952983511669418 0.3642011966354753 2.2414972503936066 0.08741850609588601 0.22063379271791628 1.92546119928139e-07 6.715465228590339 0.46974960812073574 TIVITSHPGQIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIVITSHPGQIVK 13 0 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 65788600.0 20492100.0 15864600.0 29431900.0 False True 19841589.502308432 22199417.512796044 21722802.45192616 1.0 1.1188326172262204 1.0948116051588943 24.24202426832559 -10.081011821308515 4.358799976168302 0.9999894567263772 1.1068221112035372 0.963461065792954 0.009806537148758414 1.0048489620056095e-06 2.1186245537769226e-07 0.009496075815286182 0.0031650462499213283 8.298281796418084e-11 10.081011821308515 0.10683265447716006 TIVITSHPGQIVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIVITSHPGQIVK 13 0 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 110978700.0 24744300.0 60007000.0 26227400.0 False True 37538912.15064272 49298282.01316902 21043542.894122194 1.0 1.3132581417206828 0.5605794544518227 25.161883506772085 -6.793672581995676 1.481699308086479 1.1742464690291263 0.5517523188482485 0.8129889424662253 0.13350324161610064 0.2299165268763642 0.9970672710069423 0.0709074083358039 0.16557347320610027 1.6081531953722778e-07 6.793672581995676 -0.6224941501808778 TIVITSHPGQIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIVITSHPGQIVK 13 0 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 96506700.0 25251000.0 23510200.0 47745500.0 False True 34586977.08261685 22471441.626165226 36468996.24943888 1.0 0.6497081711561083 1.0544140981828656 25.04372559123561 -6.6777597189956275 1.9095961239156733 0.7779256302592763 1.0528572199525188 0.31400411522095106 0.1485346878511988 0.443523513102388 3.1249099224810304 0.06245525243815319 0.1652109906871973 2.100101480066231e-07 6.6777597189956275 0.2749315896932425 TIVITSHPGQIVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIVITSHPGQIVK 13 0 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 43770500.0 20492100.0 11927100.0 11351300.0 False True 17040089.103954528 11862846.344956003 13724804.347518818 1.0 0.6961727883337752 0.805442052784435 24.022429543759866 -10.37958161321732 4.990970612955513 1.0001995469845832 0.750807420559066 0.8739675429605409 0.044608990412360994 9.912874004644448e-05 1.2322544595654082e-05 0.043226827185421264 0.01439748974649735 4.172711769226085e-11 10.37958161321732 -0.24939212642551722 TIVITSHPGQIVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIVITSHPGQIVK 13 0 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 85048800.0 24744300.0 36594100.0 23710400.0 False True 32031984.13307357 34557606.16620077 19395350.489248607 1.0 1.0788468807500269 0.6054995035172541 24.933009828864535 -6.864088266546661 1.164811060011374 1.0433438598252907 0.5807110762636106 0.9584241577442025 0.042222076803688724 0.14265479985511656 0.36547827998317817 0.02821949362046269 0.06621076205627992 1.3674508749472764e-07 6.864088266546661 -0.46263278356168 TIVK(ub)CAVNQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIVKCAVNQR 10 1 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 1 1445060.0 551130.0 464220.0 429710.0 True False 533634.6798233093 649585.4668753188 317156.05997632456 1.0 1.217284954363164 0.5943318003270279 19.025492901797616 -6.812484090747251 1.4041141714938605 1.1180732388939019 0.5828074764533341 0.8662117785280936 0.09442979402021678 0.20342660866263734 0.7899834193722333 0.052874472163672234 0.12217491683419424 1.539982938309876e-07 6.812484090747251 -0.5352657624405678 TIVK(ub)FSDEYLTKQWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIVKFSDEYLTKQWK 15 2 O95243-6;O95243-3;O95243-5;O95243-2;O95243 O95243-6 MBD4 Methyl-CpG-binding domain protein 4 1 121601000.0 20952000.0 30563000.0 70086000.0 True False 27468274.8994566 26003119.533640932 62834173.03238409 1.0 0.9466600880041195 2.287517991660522 24.711262971343555 -6.8976360365388985 0.976103199622582 0.9405787554756597 2.4216920939019024 0.9853527060919104 0.07502362501616212 0.113165940398818 0.18740096972090162 0.057892951351168065 0.14891633389595874 1.26579671267895e-07 6.8976360365388985 1.4811133384262427 up TIVK(ub)FSDEYLTKQWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIVKFSDEYLTKQWK 15 2 O95243-6;O95243-3;O95243-5;O95243-2;O95243 O95243-6 MBD4 Methyl-CpG-binding domain protein 4 1 224530000.0 40039000.0 80891000.0 103600000.0 True False 60742090.24298853 66455369.04573233 83123414.590507 1.0 1.094057988124689 1.3684648364583067 25.85619321926461 -6.952076346461964 0.5355627642094912 0.9958378416380673 1.4792611799279267 0.9993543209051176 0.003972020382442842 0.08266253010940117 0.03259340067206088 0.004395892605184573 0.022709379644438782 1.1166669269277815e-07 6.952076346461964 0.4834233382898594 TIVK(ub)FSDEYLTKQWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIVKFSDEYLTKQWK 15 2 O95243-6;O95243-3;O95243-5;O95243-2;O95243 O95243-6 MBD4 Methyl-CpG-binding domain protein 4 1 142282000.0 20952000.0 37727000.0 83603000.0 True False 28698520.60651016 36060096.39349452 63857693.25783245 1.0 1.256514120986237 2.22512143163737 24.774473032866446 -6.9461995299405945 0.5991166063006979 0.9890685314848026 2.542075257982782 0.9988682852647218 0.017747791710862396 0.08504866570286379 0.042561586965546 0.0182311965712753 0.08137595052240158 1.1318802187473224e-07 6.9461995299405945 1.5530067264979794 up TIVK(ub)FSDEYLTKQWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIVKFSDEYLTKQWK 15 2 O95243-6;O95243-3;O95243-5;O95243-2;O95243 O95243-6 MBD4 Methyl-CpG-binding domain protein 4 1 119301000.0 40039000.0 57601000.0 21661000.0 True False 51831274.786683396 54395453.71465163 17718920.26062886 1.0 1.049471654681876 0.3418576975687514 25.62731954135706 -6.890126531919385 1.0215993984877059 1.0379055296277557 0.28083737858035224 0.9809803697208153 0.04448269145438046 0.11904192266634182 0.22123158867049286 0.033170429057836674 0.08273491132013398 1.2878742741987824e-07 6.890126531919385 -0.7570681510474035 down TIVMGASFR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TIVMGASFR 9 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 70625900.0 16399500.0 27418200.0 26808200.0 False True 21499903.312983908 23327511.43530651 24034344.626412656 1.0 1.0850054112205658 1.1178815214437818 24.357826836110352 -13.999999998636767 0.13148432086395584 0.5959204703575215 1.1630659932353933 0.999638935671883 0.0009437715932454613 11.934545326453712 0.11290486417813854 1.244695378075161 0.04020685877415119 1.0000000031389602e-14 13.999999998636767 0.5671455228778718 TIVMGASFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIVMGASFR 9 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 33235100.0 15406000.0 7791100.0 10038000.0 False True 14916944.96281804 10902126.860049758 7408746.666454937 1.0 0.7308552044151391 0.49666648800555147 23.830448761581167 -6.972754283125255 0.1806666737318491 1.1794485956184086 0.0417360188290251 0.99999665976526 0.00037580824546244 0.07541871573659192 0.005701904195345248 0.008965322672539387 0.026228060458273358 1.0647452636858122e-07 6.972754283125255 -1.1377125767893836 down TIVMGASFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIVMGASFR 9 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 162375000.0 30825000.0 51305000.0 80245000.0 False True 46763778.60935893 42149221.902205355 64384540.57736709 1.0 0.9013219879920042 1.3768036393124503 25.478888171513447 -6.85257109753031 1.2226481728773781 0.9472035264508464 1.3967723388545628 0.9439599239847616 0.04850200906598512 0.1546517977129605 0.44358909084301523 0.03101999050493441 0.07190882434235105 1.4041997858625623e-07 6.85257109753031 0.4495688124037164 TIVMGASFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIVMGASFR 9 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 40833000.0 14689000.0 12368000.0 13776000.0 False True 20119920.255299173 11821540.86449334 10522392.525625866 1.0 0.5875540615713817 0.5229838086885301 24.26212125128776 -13.999999999999998 0.26102508322686213 4.035505019817321 0.49961449322836626 0.999564432561039 0.004409859756982249 14.462669954221253 0.16167898127119637 23.17139340538426 0.028077595750897237 1.0000000000000041e-14 13.999999999999998 -3.5358905265889544 TIVMGASFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIVMGASFR 9 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 33929600.0 15406000.0 11803000.0 6720600.0 False True 12810771.601520747 11739414.89628794 8125846.387456497 1.0 0.916370634138413 0.6342979673833145 23.610854037015443 -6.948791407280852 0.5719568874391799 1.0034834212210406 0.5334248106560676 0.999103003376275 0.004685737450772758 0.08397469246854994 0.03799885900090615 0.004953243777686024 0.023513610292541374 1.125145254269861e-07 6.948791407280852 -0.470058610564973 TIVMGASFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIVMGASFR 9 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 169628000.0 30825000.0 82451000.0 56352000.0 False True 39903570.15159011 77862529.369746 46096514.22034799 1.0 1.951267244358166 1.1551977440923566 25.250014493605896 -10.124676671417179 4.217394397038953 0.9998893667907826 1.5532324938517459 0.39170898154038625 0.32499401282316515 41680477.58123562 25015561.288843323 39878.51015417623 0.11125409611658227 7.50452707126057e-11 10.124676671417179 0.5533431270609633 TIVQLENEIYQIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIVQLENEIYQIK 13 0 O75934 O75934 BCAS2 Pre-mRNA-splicing factor SPF27 0 4443900.0 1521900.0 1350500.0 1571500.0 False True 1473588.117545943 1889761.692764462 1159877.0060105533 1.0 1.2824219130591243 0.7871107212388275 20.490901902568925 -6.752024891543329 1.6421775227601056 1.165658943924494 0.7859611524247319 0.6577232194088958 0.1186896945673639 0.29651876758180046 1.5738533819726623 0.05707823816608243 0.13828664784326533 1.7700075076128294e-07 6.752024891543329 -0.3796977914997621 TIVSIGDPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIVSIGDPK 9 0 Q13177 Q13177 PAK2 Serine/threonine-protein kinase PAK 2;PAK-2p27;PAK-2p34 0 5092800.0 1509400.0 1931100.0 1652300.0 False True 1953948.0547221454 1823632.5874266713 1351598.3540296876 1.0 0.9333065856174947 0.6917268607848877 20.897960683410975 -6.947156286796249 0.5892426646551288 1.0027986507316846 0.610094759698085 0.9989587577400619 0.004273308989253528 0.0846482599382093 0.04084689408985222 0.004433759318550849 0.020233765404177012 1.1293894153408215e-07 6.947156286796249 -0.3927038910335996 TIVTNEYMK(ub)DDFFIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIVTNEYMKDDFFIK 15 1 P48739;P48739-2;P48739-3;B3KYB6;B3KYB7 P48739 PITPNB Phosphatidylinositol transfer protein beta isoform 1 21130100.0 6948800.0 7421500.0 6759800.0 True False 10541837.625327293 6097075.340555839 5423722.56707441 1.0 0.5783693087728188 0.5144949827384596 23.329623039902415 -13.999999999999998 0.2657104272681524 4.180642232899323 0.4923954642894855 0.9995741903552855 0.0044447717746205675 14.677304318329247 0.16314672563866428 25.152564976059406 0.02710984176026173 1.0000000000000041e-14 13.999999999999998 -3.688246768609837 TIVTNEYMK(ub)DDFFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIVTNEYMKDDFFIK 15 1 P48739;P48739-2;P48739-3;B3KYB6;B3KYB7 P48739 PITPNB Phosphatidylinositol transfer protein beta isoform 1 12024600.0 4742200.0 4503400.0 2779000.0 True False 3943349.415080601 4479139.290345088 3360076.051355772 1.0 1.1358717726649987 0.8520868169850206 21.91099012077156 -6.776510815036487 1.5494585091759674 1.077282676969128 0.8500796491003482 0.7548526649122269 0.05737961238677619 0.2560334409456502 1.2138630844721385 0.029174724509708948 0.06904379691233299 1.6729739745755794e-07 6.776510815036487 -0.22720302786877977 TIVTNEYMK(ub)DDFFIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIVTNEYMKDDFFIK 15 1 P48739;P48739-2;P48739-3;B3KYB6;B3KYB7 P48739 PITPNB Phosphatidylinositol transfer protein beta isoform 1 22875200.0 6948800.0 7101200.0 8825200.0 True False 8995358.581325864 6706011.977543508 7219104.154198874 1.0 0.7454969045330797 0.8025365624874088 23.100749361994865 -10.819261976314353 7.16716146485551 1.0114471581598052 0.7740167335102442 0.9543971800679284 0.023286342848498332 0.0043214124152303095 0.00010897518677722466 0.022875185859072587 0.007515634837192522 1.5161355241103687e-11 10.819261976314353 -0.237430424649561 TIVWEGK(ub)NENEVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TIVWEGKNENEVGR 14 1 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 1 18216400.0 2176400.0 2640000.0 13400000.0 True False 2107311.3733011307 3694165.767418123 9890138.008616857 1.0 1.753023219170105 4.693249480794016 21.00697206977648 -6.945429729295621 0.6069501256669446 0.9673239253834184 5.631266994844454 0.9987920561669212 0.05538151727199266 0.08537451229070912 0.0439693240783369 0.05645777620579898 0.24766467943081788 1.1338882912377159e-07 6.945429729295621 4.663943069461036 TIVWEGK(ub)NENEVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TIVWEGKNENEVGR 14 1 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 1 65650500.0 4221500.0 16599000.0 44830000.0 True False 6404324.132989738 13636778.76142104 35969330.85031295 1.0 2.1293080234923973 5.616413239459407 22.610614896107617 -6.950800149646708 0.5499887929036001 0.9517712030662856 6.957766107572991 0.9992625914222883 0.053356635180127863 0.0831660191029636 0.034644850037245656 0.057912850422845386 0.28928428946029633 1.119953136477778e-07 6.950800149646708 6.005994904506705 TIVWEGK(ub)NENEVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TIVWEGKNENEVGR 14 1 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 1 12748900.0 1378900.0 2856400.0 8513600.0 True False 1888716.5933713692 2730194.8031483493 6502863.023095841 1.0 1.4455291030587798 3.443006243455613 20.848974807306636 -6.942264022351622 0.6381525765410568 0.9781583604550345 4.019544715353966 0.9984456716459352 0.04188188670364839 0.08674876923790535 0.05001874030944115 0.04150561703287426 0.17027789577568517 1.1421837514227689e-07 6.942264022351622 3.0413863548989317 up TIVWEGK(ub)NENEVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TIVWEGKNENEVGR 14 1 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 1 19386900.0 2176400.0 4641500.0 12569000.0 True False 1809773.03086783 4616495.318234386 15197119.787510142 1.0 2.550869771786059 8.397251770418281 20.787377345210757 -6.946237987392219 0.5987234418283662 0.933959952928466 10.312784423584999 0.9988720061217885 0.10697411801703337 0.08503248946667837 0.04249204598677504 0.10993062572206268 0.4911117086042671 1.1317799934316969e-07 6.946237987392219 9.378824470656532 TIVWEGK(ub)NENEVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TIVWEGKNENEVGR 14 1 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 1 61934500.0 4221500.0 14773000.0 42940000.0 True False 5464814.9682056 13950869.563489335 35125360.60160673 1.0 2.5528530507722156 6.427548015068536 22.381741218200066 -6.955502980458821 0.4947609710788768 0.9187511542600447 8.227286381660031 0.9995653426270706 0.04758383711288304 0.08134846772961812 0.02737858573131399 0.056369164608950986 0.319585306202638 1.1078909621583631e-07 6.955502980458821 7.308535227399986 TIVYWGIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TIVYWGIGR 9 0 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 0 19339900.0 5997600.0 6559100.0 6783200.0 False True 7862911.680841025 5580507.847171551 6081339.53304893 1.0 0.7097253630317585 0.7734208115127224 22.906632218913458 -10.848712013063837 7.321156946278762 1.020171335038186 0.7415730872722404 0.9564234521285999 0.02600355795268256 0.008275183262386038 0.00017100226007669912 0.024335880691681883 0.008392612241073252 1.4167329245828367e-11 10.848712013063837 -0.27859824776594566 TK(ub)AAAPGVEDEPLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKAAAPGVEDEPLLR 15 1 P31350;P31350-2;A0A286YFD6;C9JXC1 P31350 RRM2 Ribonucleoside-diphosphate reductase subunit M2 1 10377500.0 2776300.0 2000200.0 5601000.0 True False 3639756.185727442 1701777.9567185333 5021462.248585785 1.0 0.46755273427151706 1.3796150050589706 21.795410381994607 -6.748477596674654 1.6556405150465952 0.6863422978706343 1.3812018730470264 0.6423367048177475 0.22372216987711743 0.3027037080722979 1.632094439011525 0.10677023442400567 0.25960854753487367 1.784524041843376e-07 6.748477596674654 0.6948595751763921 TK(ub)AAAPGVEDEPLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKAAAPGVEDEPLLR 15 1 P31350;P31350-2;A0A286YFD6;C9JXC1 P31350 RRM2 Ribonucleoside-diphosphate reductase subunit M2 1 14181200.0 2776300.0 2290800.0 9114100.0 True False 3802773.1366864336 2189584.8813374275 6961537.290781559 1.0 0.5757863544932196 1.8306475407700844 21.8586204435175 -6.815533074660558 1.391340100129845 0.7702715517808271 1.8554497117181858 0.8737369443844062 0.18519173874948028 0.19935517472271277 0.7595148090771209 0.10463265202123818 0.24146643767340759 1.5292092816557842e-07 6.815533074660558 1.0851781599373589 TK(ub)AAAPGVEDEPLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKAAAPGVEDEPLLR 15 1 P31350;P31350-2;A0A286YFD6;C9JXC1 P31350 RRM2 Ribonucleoside-diphosphate reductase subunit M2 1 89954300.0 6613300.0 10229000.0 73112000.0 True False 8561047.217632154 9659747.157986334 59806366.192470156 1.0 1.1283370962014228 6.985870381522276 23.029355852314698 -6.911627893392717 0.8845827177124905 0.8278435163392783 7.769803290582248 0.9915213826735724 0.2570865029805925 0.10335116724652325 0.13300338775490983 0.21218922937154913 0.5925548563248053 1.2256659087874198e-07 6.911627893392717 6.941959774242969 up TK(ub)AATIIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKAATIIQK 9 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 4647500.0 1339100.0 2061100.0 1247300.0 True False 1755573.0678628483 1753591.9141048733 1118241.3609464467 1.0 0.9988715059519643 0.6369665731473888 20.743510612509315 -6.907583355498595 0.9120384641519066 1.0120795799093172 0.5925363257741035 0.9899770992332557 0.017106576253765212 0.10603773029559843 0.1475978203001365 0.01384014493969921 0.03759447059029075 1.2371337202016562e-07 6.907583355498595 -0.41954325413521365 TK(ub)AATIIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKAATIIQK 9 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 5258200.0 1063800.0 2230700.0 1963700.0 True False 1030030.2512946808 3121430.1429468263 1449348.0602627571 1.0 3.0304256977145987 1.4070927125111339 19.974255278336475 -6.590356002963197 2.2273486861150715 2.373928720988898 1.4118154037948334 0.0 0.8797728292573874 0.6685660724988918 6.2534741586885465 0.3296580856264764 0.9806102187225153 2.568289623002644e-07 6.590356002963197 -0.9621133171940648 TK(ub)AATIIQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKAATIIQK 9 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 7004100.0 3705400.0 1792500.0 1506200.0 True False 5621362.701025744 1472614.3701335753 1208498.9098090895 1.0 0.2619675065380257 0.21498326546133942 22.422488472671397 -13.681937830426712 0.3943592118826362 9.999999949650947 0.21180229071732798 0.9998233369495535 0.004778254683134999 20.001940682239862 0.20587118655146905 152.18763805739604 0.012217364191796788 2.0799944185179564e-14 13.681937830426712 -9.788197658933619 TK(ub)AATIIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKAATIIQK 9 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 4335500.0 1339100.0 1483800.0 1512600.0 True False 1834201.4578168108 1418240.8097295626 1155355.0329748602 1.0 0.7732197593047645 0.6298953847469083 20.806720674032206 -9.756502260443105 0.07258278044045084 1.8122068493466237 9.075522655838666e-08 0.9999815987089737 0.0006535903948602626 1.2914835504788273 0.03153673274514991 0.49050439256030165 0.29960115807459914 1.7518533160290363e-10 9.756502260443105 -1.812206758591397 TK(ub)AATIIQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKAATIIQK 9 1 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6 G3V394 MYO5A Unconventional myosin-Va 1 5215700.0 1063800.0 2460700.0 1691200.0 True False 884596.8343306367 2447443.7206892935 2044822.1007747003 1.0 2.7667335284341634 2.31158650067066 19.75466055377075 -10.123098983962905 5.2509827906636835 0.9999617452730624 2.5391600145536883 0.9384526303862903 0.18581299599862397 8.321869625770118e-05 1.3897443065262023e-05 0.17991709205667697 0.059970886583654445 7.531838792547435e-11 10.123098983962905 1.539198269280626 TK(ub)AATILTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKAATILTK 9 1 E9PHA2;Q15003;Q15003-2;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 1 5084200.0 2042600.0 2026800.0 1014800.0 True False 2677868.3805665383 1724409.3404045221 909798.2306489663 1.0 0.643948505056735 0.3397471799777129 21.352653622081093 -7.538335747437883 0.23941424910525247 1.1478795789500125 2.0861871412664142e-15 0.9998773674910213 0.0029880135740354575 0.1286788512892481 0.024712925853396118 0.03021488108659656 0.06827141409603567 2.8951045545026606e-08 7.538335747437883 -1.1478795789500105 down TK(ub)AATILTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKAATILTK 9 1 E9PHA2;Q15003;Q15003-2;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 1 7894800.0 2745300.0 3060700.0 2088800.0 True False 2658151.9542012443 4282853.471339649 1541680.617343202 1.0 1.611214687922766 0.5799821243877933 21.341992148470414 -6.746126963089261 1.6641029117819828 1.3610718838385667 0.5785174530804426 0.6321318911958236 0.2568035906059959 0.3068694819944484 1.6706973026224596 0.12196833259728236 0.2973290238805699 1.794209025137114e-07 6.746126963089261 -0.7825544307581241 TK(ub)AATILTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKAATILTK 9 1 E9PHA2;Q15003;Q15003-2;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 1 4533370.0 2042600.0 1514200.0 976570.0 True False 2797804.419189467 1447297.6372102047 745924.2790904802 1.0 0.5172976449974626 0.26661058720701314 21.415863683603984 -9.422284271973407 0.18982462508212528 1.5011105246718464 6.283017612692065e-26 0.999573173693333 0.006287970704296258 0.8468375973263593 0.07307779169412722 0.392418477317161 0.15037102750375697 3.7819495223836396e-10 9.422284271973407 -1.5011105246718464 TK(ub)AATILTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKAATILTK 9 1 E9PHA2;Q15003;Q15003-2;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 1 9028230.0 2745300.0 5480200.0 802730.0 True False 2282838.587411068 5450677.074865473 970577.1315958333 1.0 2.3876751974159514 0.4251623995442227 21.12239742390469 -6.716765120068547 1.7710860074890924 1.8471684525595544 0.42880097254524674 0.4971053198152473 0.5841848991813338 0.36166537974689994 2.2153137523084934 0.26209070178388183 0.6604297583833212 1.9197066969134187e-07 6.716765120068547 -1.4183674800143078 TK(ub)ADSVPGTYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKADSVPGTYR 11 1 Q15004;H0YMA4;A0A0U1RQM0;H0YKX3;A0A0U1RQC1;Q15004-2 Q15004 KIAA0101 PCNA-associated factor 1 3114540.0 892120.0 1361600.0 860820.0 True False 863800.1389217988 1905293.9806501989 635345.4179535509 1.0 2.205711593226183 0.7355236348382549 19.7203380230051 -6.688753071234382 1.870732278848082 1.7567869910844487 0.7406693727428785 0.3646200847233003 0.5100614849842291 0.4193705399168737 2.844496192175239 0.21819252041592532 0.5691071217118557 2.0476085237969169e-07 6.688753071234382 -1.0161176183415703 TK(ub)AEATIPLVPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKAEATIPLVPGR 13 1 Q9BT67 Q9BT67 NDFIP1 NEDD4 family-interacting protein 1 1 141973000.0 26525000.0 52137000.0 63311000.0 True False 34774531.86846542 44358362.82843425 56760185.041995086 1.0 1.275599136638838 1.632234339104559 25.05152775768245 -6.967595352091441 0.3102971314298966 0.9452498139889878 1.9739249119631652 0.9999570852115489 0.0016954669281308901 0.07709095880801768 0.011809083833283092 0.005635124375497751 0.03165329696875175 1.0774686626851304e-07 6.967595352091441 1.0286750979741774 TK(ub)AEATIPLVPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKAEATIPLVPGR 13 1 Q9BT67 Q9BT67 NDFIP1 NEDD4 family-interacting protein 1 1 66967000.0 20548000.0 19827000.0 26592000.0 True False 19895714.987406548 27744024.49643908 19626757.457099985 1.0 1.3944723531675187 0.9864816353432483 24.24595440995095 -6.653852327038458 1.9947187525891759 1.2551928750938914 0.9881950482788159 0.20978818885795658 0.16820749983900016 0.4992014677731562 3.8114978818386227 0.0682854655226355 0.18636396403003652 2.2189508004011642e-07 6.653852327038458 -0.26699782681507556 TK(ub)AEATIPLVPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKAEATIPLVPGR 13 1 Q9BT67 Q9BT67 NDFIP1 NEDD4 family-interacting protein 1 1 150444000.0 47017000.0 72544000.0 30883000.0 True False 71328226.40312183 59597956.411140986 24778961.51350022 1.0 0.8355451890015388 0.34739349010948795 26.08796976519145 -6.951689751990467 0.5399806556462629 1.0071877725856129 0.15320904148662307 0.9993272656221267 0.00718807435117486 0.08281436167707593 0.03320941058106102 0.007906274357952804 0.040425698598558386 1.1176613891572848e-07 6.951689751990467 -0.8539787310989898 down TK(ub)AEATIPLVPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKAEATIPLVPGR 13 1 Q9BT67 Q9BT67 NDFIP1 NEDD4 family-interacting protein 1 1 103746000.0 26525000.0 22936000.0 54285000.0 True False 36332009.31117236 21922611.680790663 41464001.034669064 1.0 0.6033966217786171 1.1412526260120324 25.11473781920534 -6.709106141686328 1.798062238082754 0.7559624200565066 1.1399750631909114 0.4610278583547611 0.1671492031299742 0.37686366287118844 2.374453997923545 0.07398769401350669 0.18819068144839385 1.95386187305817e-07 6.709106141686328 0.38401264313440475 TK(ub)AEATIPLVPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKAEATIPLVPGR 13 1 Q9BT67 Q9BT67 NDFIP1 NEDD4 family-interacting protein 1 1 68786000.0 20548000.0 28345000.0 19893000.0 True False 17086572.430744413 28192299.85895803 24052534.325160287 1.0 1.6499681239890294 1.4076863234361618 24.026359685385227 -10.174732349142257 4.865925565896728 0.9999489953506372 1.528827223714222 0.8639864508454439 0.09891113089186668 5.473658120050089e-05 9.282990532132056e-06 0.09577949554875081 0.03192343022409005 6.687559374383873e-11 10.174732349142257 0.5288782283635848 TK(ub)AEATIPLVPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKAEATIPLVPGR 13 1 Q9BT67 Q9BT67 NDFIP1 NEDD4 family-interacting protein 1 1 120878000.0 47017000.0 55248000.0 18613000.0 True False 60864433.34362736 52173400.23310489 15225624.985507812 1.0 0.857206702944973 0.25015635814018417 25.8590960872839 -6.943477413160276 0.6263782036475903 1.0066244804359221 0.06822442940665294 0.9985848096894705 0.012229654069425508 0.08621544623811779 0.04765015856015212 0.012245500505873145 0.05150116667307723 1.1389970174293985e-07 6.943477413160276 -0.9384000510292692 down TK(ub)AEATIPLVPGRDEDFVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKAEATIPLVPGRDEDFVGR 20 2 Q9BT67 Q9BT67 NDFIP1 NEDD4 family-interacting protein 1 1 29616700.0 8005000.0 10097200.0 11514500.0 True False 10494632.52053028 8590737.11857734 10323089.99488325 1.0 0.8185838905527739 0.9836542608508257 23.32314831439658 -10.37664979176793 6.898471409952962 1.0000049539192994 0.9011190757118571 0.32361038397789044 0.06738969648041648 5.1347418207445e-06 4.6403391302212917e-07 0.06525306165781504 0.021749931014552137 4.200976075384274e-11 10.37664979176793 -0.09888587820744232 TK(ub)AEATIPLVPGRDEDFVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKAEATIPLVPGRDEDFVGR 20 2 Q9BT67 Q9BT67 NDFIP1 NEDD4 family-interacting protein 1 1 25133100.0 8005000.0 5851400.0 11276700.0 True False 10964664.82699094 5592865.800007784 8613375.710926622 1.0 0.5100808723528166 0.7855575931262108 23.38635837591947 -10.153469581493242 5.479994070241048 1.0000080869351706 0.6478192327394503 0.6854570027786935 0.11246290031855644 1.1111852882820198e-05 1.7162607088220666e-06 0.10889423432642194 0.0362972449999632 7.023125328258351e-11 10.153469581493242 -0.3521888541957203 TK(ub)AEATIPLVPGRDEDFVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKAEATIPLVPGRDEDFVGR 20 2 Q9BT67 Q9BT67 NDFIP1 NEDD4 family-interacting protein 1 1 22835500.0 8723400.0 10617300.0 3494800.0 True False 7253893.6121450225 10560102.497530947 4225546.521870515 1.0 1.4557840329847707 0.5825211600561363 22.790324155774314 -6.7648748557751555 1.594158452997007 1.2631310922485552 0.5785413289080111 0.7105595041726116 0.19186168019074895 0.27478986539514344 1.377345212408093 0.09491403156402364 0.22700573188955656 1.7184034827669377e-07 6.7648748557751555 -0.6845897633405441 TK(ub)AEATIPLVPGRDEDFVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKAEATIPLVPGRDEDFVGR 20 2 Q9BT67 Q9BT67 NDFIP1 NEDD4 family-interacting protein 1 1 52848000.0 27354800.0 22829000.0 2664200.0 True False 35411327.84372156 21558546.081696164 2179342.9370004795 1.0 0.6088036623997567 0.061543666100814624 25.077707606715713 -7.608045029304385 0.5664869913979617 1.006719868851552 2.9666230020503516e-20 0.9936940729911747 0.030563668484800615 0.11762639374348953 0.10356362404075618 0.030786882408888907 0.07428822830817042 2.4657836621474243e-08 7.608045029304385 -1.006719868851552 down TK(ub)AGQGTSAPPEASPTAAPESSTSFPPAPTSGMSHPPPAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKAGQGTSAPPEASPTAAPESSTSFPPAPTSGMSHPPPAAR 41 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 94172200.0 33435000.0 45527000.0 15210200.0 True False 43833608.785000585 38734549.062856026 13636394.410540875 1.0 0.8836723723306714 0.3110944954914848 25.38553412386123 -6.940156130842919 0.6581097200628541 1.0064101697140058 0.15597685227486136 0.9981842742452307 0.012830408426698399 0.08769548505488492 0.054285903140566034 0.012504257131592455 0.04924682928145187 1.1477409292309968e-07 6.940156130842919 -0.8504333174391444 down TK(ub)AGQGTSAPPEASPTAAPESSTSFPPAPTSGMSHPPPAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKAGQGTSAPPEASPTAAPESSTSFPPAPTSGMSHPPPAAR 41 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 120122000.0 47610000.0 49451000.0 23061000.0 True False 46098646.6103964 69197042.18355829 17020632.284829352 1.0 1.501064505610727 0.36922195197354823 25.45822106004769 -6.786357607441113 1.5107404279441459 1.2813836267118428 0.3583448192466789 0.7893249619763888 0.21255216467852078 0.24083406999880524 1.0858920463358854 0.1107640562433318 0.260043126245016 1.6354692861567146e-07 6.786357607441113 -0.9230388074651639 down TK(ub)AGQGTSAPPEASPTAAPESSTSFPPAPTSGMSHPPPAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKAGQGTSAPPEASPTAAPESSTSFPPAPTSGMSHPPPAAR 41 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 188835000.0 95372000.0 79597000.0 13866000.0 True False 144686296.6271461 65392293.45580049 11125379.022316307 1.0 0.4519591349021478 0.07689310792843225 27.108353048458255 -8.246156212644534 0.41804438428862223 1.0687808638214154 5.856503360360792e-25 0.9965292570170359 0.02233131774444942 0.11300215988372123 0.11286081293027928 0.06535095496690516 0.08050950920360313 5.673405003495507e-09 8.246156212644534 -1.0687808638214154 TK(ub)AGQGTSAPPEASPTAAPESSTSFPPAPTSGMSHPPPAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKAGQGTSAPPEASPTAAPESSTSFPPAPTSGMSHPPPAAR 41 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 101868300.0 33435000.0 51405000.0 17028300.0 True False 45796823.04690091 49133757.12639711 13006566.248846924 1.0 1.0728638769566792 0.2840058629291117 25.448744185384122 -6.884305446227258 1.0554595901618975 1.0483508317821444 0.22326272807539269 0.97699703789502 0.05398478459226784 0.12388621849456939 0.2498005418889953 0.039234172920837994 0.09600914519065577 1.3052525603145898e-07 6.884305446227258 -0.8250881037067517 down TK(ub)AGQGTSAPPEASPTAAPESSTSFPPAPTSGMSHPPPAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKAGQGTSAPPEASPTAAPESSTSFPPAPTSGMSHPPPAAR 41 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 116937600.0 47610000.0 58867000.0 10460600.0 True False 39589824.48061812 58549871.786815315 12647863.095650304 1.0 1.478912133482163 0.3194725731063113 25.238626335481968 -6.794528197028614 1.478123348686541 1.266095488142184 0.3055434104811146 0.815688309447347 0.20423335018690233 0.22866274615560586 0.9867826403239149 0.10872872027823403 0.2537546764186104 1.6049880491672146e-07 6.794528197028614 -0.9605520776610694 down TK(ub)AGQGTSAPPEASPTAAPESSTSFPPAPTSGMSHPPPAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKAGQGTSAPPEASPTAAPESSTSFPPAPTSGMSHPPPAAR 41 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 199262300.0 95372000.0 82059000.0 21831300.0 True False 123460934.06317765 77492344.51434176 17858227.408054423 1.0 0.6276669223536511 0.14464678680396165 26.879479370550705 -7.517676872793474 0.46106030174071216 1.0219641591632804 7.875987277726582e-27 0.9978709434250873 0.01615742547608164 0.11743285077793694 0.0625422369548005 0.020938594447350523 0.06855601059891986 3.0361493238024144e-08 7.517676872793474 -1.0219641591632804 down TK(ub)ASVHTLSGHTNAVATVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKASVHTLSGHTNAVATVR 19 1 O43660-2;O43660;H0YA24 O43660-2 PLRG1 Pleiotropic regulator 1 1 9537600.0 1151600.0 1494000.0 6892000.0 True False 1115043.088353971 2090561.9911070769 5086778.444431905 1.0 1.874871036771475 4.561956840556734 20.088668030280065 -6.9509205620889265 0.5486437802563694 0.9625361754739757 5.600233884782303 0.9992715626038722 0.040905382130598564 0.08311817680251465 0.034448670806056174 0.044475493972124795 0.2228600812295961 1.1196426614324813e-07 6.9509205620889265 4.637697709308327 TK(ub)ASVHTLSGHTNAVATVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKASVHTLSGHTNAVATVR 19 1 O43660-2;O43660;H0YA24 O43660-2 PLRG1 Pleiotropic regulator 1 1 6228100.0 1151600.0 3014700.0 2061800.0 True False 957606.4245301384 2998459.2127289055 2492912.8473139 1.0 3.1312020637289866 2.6032749817202605 19.86907330571434 -10.209105461651754 5.009664890042738 0.999796256766339 2.867238522726508 0.9434382265140239 0.21552532872617366 0.0004904977220421439 7.743631915274679e-05 0.20870309178917892 0.06956050073592708 6.178663427001742e-11 10.209105461651754 1.8674422659601688 TK(ub)ASVHTLSGHTNAVATVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKASVHTLSGHTNAVATVR 19 1 O43660-2;O43660;H0YA24 O43660-2 PLRG1 Pleiotropic regulator 1 1 9891600.0 2247300.0 3531300.0 4113000.0 True False 2909174.1509057106 3334780.0507378173 3364476.2029438335 1.0 1.1462978418461485 1.156505602078299 21.472178231911496 -13.062779153082975 0.3894573142403825 2.083609496063659e-06 1.1572849931788038 0.9997952620845022 0.0010229533616952491 12.075061635266675 0.20307228216690426 9.88294472989318 0.0026913252051392837 8.654078830957887e-14 13.062779153082975 1.1572829095693078 TK(ub)DGQILPVPNVVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKDGQILPVPNVVVR 15 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 17222200.0 5248800.0 6922400.0 5051000.0 True False 6881227.629451511 5889604.903303852 4528370.972613251 1.0 0.8558945031983052 0.658076031845236 22.714234537874848 -6.966688989348651 0.32777876816044155 1.024733391999096 0.48278276114487884 0.9999438408921915 0.001050355616835316 0.07739246697327797 0.012864024924574871 0.0029097724184842895 0.017285404377903563 1.0797196634459122e-07 6.966688989348651 -0.5419506308542171 TK(ub)DGQILPVPNVVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKDGQILPVPNVVVR 15 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 24458500.0 11512000.0 6576600.0 6369900.0 True False 11146557.861350212 9202670.676515928 4701432.097096158 1.0 0.8256065048049895 0.42178331244284784 23.41009492834429 -6.957082376699302 0.47477423935910573 1.010185953104521 0.22051546838855443 0.9996461986840197 0.0045551362172021916 0.08076036652984087 0.025111259263973902 0.00563483564326505 0.033319732705969024 1.1038692188364146e-07 6.957082376699302 -0.7896704847159666 down TK(ub)DGQILPVPNVVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKDGQILPVPNVVVR 15 1 Q9P258 Q9P258 RCC2 Protein RCC2 1 24490500.0 11512000.0 7355200.0 5623300.0 True False 9572738.06807133 7315576.077707104 6799106.030798467 1.0 0.7642093647278716 0.710257188951616 23.190500203778566 -13.999999999999998 0.2072184551573513 2.3483128783804363 0.6776091075049642 0.9994886375649507 0.0028450319185654837 12.68302386380277 0.14430208541881315 6.953171575757827 0.03259298516218812 1.0000000000000041e-14 13.999999999999998 -1.6707037708754722 TK(ub)DGVVEITGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKDGVVEITGK 11 1 P04792 P04792 HSPB1 Heat shock protein beta-1 1 56969000.0 16870000.0 17777000.0 22322000.0 True False 22116733.369312394 15124740.894203272 20012333.5677436 1.0 0.6838596207516471 0.9048503336171376 24.398634980167888 -10.11365721492971 5.385674749538829 1.00000346389127 0.7943549785236589 0.5358741756322407 0.09021908073607413 3.7523962396503043e-06 6.175463423660454e-07 0.08735572005371359 0.029118083100029578 7.697377482709128e-11 10.11365721492971 -0.20564848536761116 TK(ub)DGVVEITGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKDGVVEITGK 11 1 P04792 P04792 HSPB1 Heat shock protein beta-1 1 90144000.0 18157000.0 24513000.0 47474000.0 True False 17580615.97363932 34301168.7336063 35039135.21052812 1.0 1.9510788919477033 1.9930550364712138 24.067482283415636 -11.00844511273495 0.5441497480446121 8.446085452305246e-08 1.989642049414205 0.9998561420783165 0.005499966634895242 2.868573203366391 0.2658018929283285 3.596576722413069 0.007909205074128102 9.807422552442976e-12 11.00844511273495 1.9896419649533506 TK(ub)DGVVEITGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKDGVVEITGK 11 1 P04792 P04792 HSPB1 Heat shock protein beta-1 1 355430000.0 42214000.0 73046000.0 240170000.0 True False 64041724.2567876 60010370.58899706 192700294.22974944 1.0 0.9370511379171171 3.008980418095562 25.932508815651413 -6.899892197667681 0.9619395851764118 0.9136017748759346 3.2259960649442747 0.9865128785784222 0.1117468557640328 0.11148500137226332 0.17786359319968925 0.08714380417003786 0.22661331366378734 1.2592379461378713e-07 6.899892197667681 2.3123942900683403 up TK(ub)DGVVEITGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKDGVVEITGK 11 1 P04792 P04792 HSPB1 Heat shock protein beta-1 1 51368000.0 16870000.0 15914000.0 18584000.0 True False 23107294.894608002 15210866.859439425 14194841.949494116 1.0 0.6582712052109926 0.6143013284002545 24.46184504169078 -13.999999999999998 0.2890842615154754 3.9295280020417884 0.6022084548882417 0.9996254124918444 0.0033365424201950173 15.911491773219392 0.1704843441516837 27.70627106121315 0.016675240808387958 1.0000000000000041e-14 13.999999999999998 -3.3273195471535466 TK(ub)DGVVEITGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKDGVVEITGK 11 1 P04792 P04792 HSPB1 Heat shock protein beta-1 1 74923000.0 18157000.0 34458000.0 22308000.0 True False 15098349.991484642 34272367.914622486 26972499.659461897 1.0 2.2699412806003205 1.7864534650921582 23.847887558849912 -10.339245722687227 5.314110665585409 0.9996832219122033 2.0281973728462837 0.8577534266274905 0.19738307414147044 0.0007410106457780467 9.213663972411743e-05 0.1911713070677456 0.06370511324773907 4.578827445456431e-11 10.339245722687227 1.0285141509340803 TK(ub)DGVVEITGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKDGVVEITGK 11 1 P04792 P04792 HSPB1 Heat shock protein beta-1 1 382619000.0 42214000.0 71355000.0 269050000.0 True False 54646855.16234306 67384031.5239139 220085660.68612677 1.0 1.233081598634206 4.027416765929231 25.703635137743863 -6.92340768484175 0.7990495842024163 0.9455834009276406 4.515343008738025 0.9950762684315457 0.09651755800711706 0.0962080710009606 0.09552787158897047 0.08469727974601578 0.26259716694791896 1.1928677990719618e-07 6.92340768484175 3.5697596078103846 up TK(ub)DGVVEITGK(ub)HEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKDGVVEITGKHEER 15 2 P04792 P04792 HSPB1 Heat shock protein beta-1 2 2327140.0 566160.0 790250.0 970730.0 True False 470787.12514065905 785992.766397657 1173705.1548515994 1.0 1.6695290173086672 2.4930697807441664 18.844715341224163 -6.968344844857196 0.29505801205614973 0.8485168083169172 3.339706931667505 0.9999664381431911 0.0035374938114220576 0.07684354537450871 0.010942561363870947 0.014009087984405146 0.07425603912242643 1.075610802235841e-07 6.968344844857196 2.491190123350588 TK(ub)DNNLLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKDNNLLGK 9 1 E9PM13 E9PM13 HSPA8 1 6819100.0 2319900.0 2323100.0 2176100.0 True False 2246256.0443490557 3250725.944806457 1606114.128399341 1.0 1.4471751575179344 0.7150182778316253 21.099090955147616 -6.741402423421044 1.6814403549760566 1.265633467416586 0.7144464182202016 0.6112639838643847 0.18787946796092608 0.3152896584270983 1.750776146071908 0.08837380844981209 0.21653861054410423 1.8138341594062233e-07 6.741402423421044 -0.5511870491963845 TK(ub)DNNLLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKDNNLLGK 9 1 E9PM13 E9PM13 HSPA8 1 10328500.0 2827000.0 4985800.0 2515700.0 True False 4288765.681383874 4096045.0357667957 2018470.7923295207 1.0 0.9550638435544251 0.4706414251286893 22.03213106516706 -6.924999046144786 0.7867553818442391 1.0088888098404651 0.38277325074597524 0.9954607961796241 0.016146331260917437 0.09531888832360087 0.0910188386428986 0.014293773361919344 0.04509698090955423 1.1885048377863051e-07 6.924999046144786 -0.6261155590944899 down TK(ub)DNNLLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKDNNLLGK 9 1 E9PM13 E9PM13 HSPA8 1 5275100.0 2038400.0 1582900.0 1653800.0 True False 2792051.5656887344 1512962.2440496846 1263206.5010801437 1.0 0.541881913157457 0.4524295025935669 21.41289415588479 -13.99999999999998 0.22965392081243685 3.887339915258765 0.4087935138978033 0.9995093229392077 0.005312739702262907 13.280515973399787 0.1517389662569962 17.481536262045857 0.0465339860872348 1.000000000000045e-14 13.99999999999998 -3.478546401360962 TK(ub)DNNLLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKDNNLLGK 9 1 E9PM13 E9PM13 HSPA8 1 6887800.0 2319900.0 3391800.0 1176100.0 True False 1929099.6389957138 3373527.700180409 1422017.0723280064 1.0 1.7487576234976967 0.7371402925917845 20.879496230581893 -6.708454822889584 1.800848199160364 1.461043367812902 0.7396356405864043 0.45773208552417965 0.3155990112650722 0.3781721494744465 2.3897806392104486 0.13951810113242497 0.3550892802136498 1.9567943111953614e-07 6.708454822889584 -0.7214077272264977 TK(ub)DNNLLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKDNNLLGK 9 1 E9PM13 E9PM13 HSPA8 1 9323500.0 2827000.0 5170100.0 1326400.0 True False 3659607.2285010684 4882379.390116838 1085008.810013301 1.0 1.334126611209204 0.2964823114249088 21.80325738725951 -6.820030170731419 1.3716741776422532 1.1800857378410827 0.27380085035286444 0.8844748045096692 0.14699268548718397 0.1934366474036301 0.7151212774494714 0.08421029082708106 0.1940962037093717 1.5134561039647614e-07 6.820030170731419 -0.9062848874882183 down TK(ub)DSLVLNNITR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKDSLVLNNITR 12 1 P56182 P56182 RRP1 Ribosomal RNA processing protein 1 homolog A 1 5968310.0 979410.0 0.0 4988900.0 True False 1284015.9946199316 0.0 4472696.484907985 1.0 0.0 3.48336508551975 20.29223174313574 -6.8299401887256215 1.3280823367836545 0.4656324551661858 3.5770474479231584 0.9057710255581062 0.4495315166708501 0.18088612375787866 0.6239806342513081 0.2657572482265609 0.6116142666564008 1.4793121058148576e-07 6.8299401887256215 3.1114149927569725 TK(ub)DSLVLNNITR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKDSLVLNNITR 12 1 P56182 P56182 RRP1 Ribosomal RNA processing protein 1 homolog A 1 8940900.0 1805100.0 2983500.0 4152300.0 True False 1747798.0885617852 4174827.1087469673 3064688.0636701374 1.0 2.3886209374346654 1.7534565827291781 20.73710709886764 -9.92383401737827 5.575583047518557 0.9999989295855362 2.0710387600842495 0.791284089652014 0.25930476198030583 3.4502743719625845e-06 6.66309599989811e-07 0.25107100679647454 0.08369025206064128 1.1916973747633623e-10 9.92383401737827 1.0710398304987132 TK(ub)DSLVLNNITR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKDSLVLNNITR 12 1 P56182 P56182 RRP1 Ribosomal RNA processing protein 1 homolog A 1 6333310.0 979410.0 3271500.0 2082400.0 True False 1341524.3445600483 3126954.3125962107 1590580.008374225 1.0 2.3308964352948007 1.185651244290952 20.355441804658632 -6.609610831478961 2.154710449588694 1.8893881952226586 1.189692364586385 0.04929116540148393 0.5738448317198234 0.6137401303483417 5.398865448239428 0.21994490060895455 0.6372783577597282 2.456909550560857e-07 6.609610831478961 -0.6996958306362735 TK(ub)DSLVLNNITR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKDSLVLNNITR 12 1 P56182 P56182 RRP1 Ribosomal RNA processing protein 1 homolog A 1 7570600.0 1805100.0 3564700.0 2200800.0 True False 1501020.629488843 3545496.2535624467 2660977.1046505207 1.0 2.362056979036876 1.7727785030887209 20.517512374301916 -10.145154432537236 5.331928206030265 0.9999704645236566 2.0674177410632497 0.8139494281736867 0.24057193041457509 8.447022900631047e-05 1.3542394719549542e-05 0.23293918090198135 0.07764425667148857 7.158887991432483e-11 10.145154432537236 1.067447276539593 TK(ub)DSLVLNNITR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKDSLVLNNITR 12 1 P56182 P56182 RRP1 Ribosomal RNA processing protein 1 homolog A 1 10464100.0 2178000.0 2505000.0 5781100.0 True False 2819463.934798485 2365594.547928028 4728999.119095219 1.0 0.8390228081059329 1.6772688810552967 21.42698945814524 -6.856950451756209 1.2011064463160095 0.9132786212004804 1.7155486242299303 0.9498220763130617 0.0813595624321725 0.1499718168245615 0.41287856746859336 0.05289481165832544 0.12307422465793534 1.3901112186315428e-07 6.856950451756209 0.8022700030294498 TK(ub)EDEK(ub)DDKPIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKEDEKDDKPIR 12 3 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 2 30866900.0 13217400.0 11833200.0 5816300.0 True False 17328139.397483658 10067732.685452325 5214485.069889219 1.0 0.5810048300346852 0.30092584958350754 24.04661341818278 -8.27203497552392 0.21549607601427312 1.2576771328333811 1.414796468721895e-14 0.999694205944815 0.005023442107454764 0.0920506221896613 0.04757928199975005 0.10944040114846286 0.11325607504438412 5.345213104601818e-09 8.27203497552392 -1.257677132833367 down TK(ub)EDEK(ub)DDKPIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKEDEKDDKPIR 12 3 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 2 49238400.0 14460500.0 24227400.0 10550500.0 True False 14001459.342777522 33901527.164221905 7787007.541784496 1.0 2.421285262790095 0.5561568513071694 23.739073868300654 -6.702983491217682 1.8199421874831243 1.87995128433821 0.5613295722564721 0.43187669905077797 0.5996192985470019 0.3893502723167888 2.50911911851138 0.2626251965598939 0.6729985127462659 1.9816023507780067e-07 6.702983491217682 -1.3186217120817378 TK(ub)EDEK(ub)DDKPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKEDEKDDKPIR 12 3 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 2 34252400.0 13217400.0 13327800.0 7707200.0 True False 18104229.966804475 12738933.726859184 5886918.094766531 1.0 0.7036440517059835 0.3251681019055026 24.10982347970567 -7.067508319696911 0.32239444400219425 1.053857854425307 1.2076210342247318e-12 0.9999463087894364 0.0020236669342416683 0.07375381061367597 0.013064161886404822 0.006252763707221412 0.0323863357123704 8.560353126571075e-08 7.067508319696911 -1.0538578544240993 down TK(ub)EDEK(ub)DDKPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKEDEKDDKPIR 12 3 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 2 39557700.0 14460500.0 21872800.0 3224400.0 True False 12024546.458768725 21754966.884989135 3898607.1320588603 1.0 1.8092130925341174 0.32422072178995637 23.51947914373493 -6.7587105280209006 1.6171539593431012 1.4707805875964166 0.3191048915755834 0.6857642289873673 0.3402984972492338 0.28508053230662683 1.46906018018383 0.1660494644017523 0.3995798342763921 1.742968233657104e-07 6.7587105280209006 -1.1516756960208332 TK(ub)EDEKDDKPIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKEDEKDDKPIR 12 3 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 104130700.0 38417000.0 45418000.0 20295700.0 True False 37197473.363402665 63553644.25174116 14979647.312051157 1.0 1.708547342203878 0.4027060431149908 25.148701293881263 -6.759361068720121 1.6150021679414845 1.4118921155928135 0.3981049064460948 0.6883117041727965 0.2979886847755605 0.283988507935661 1.4597408883364322 0.14559617286155982 0.3500939205868699 1.7403593518570688e-07 6.759361068720121 -1.0137872091467186 TK(ub)EDEKDDKPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKEDEKDDKPIR 12 3 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 97978400.0 38417000.0 49603000.0 9958400.0 True False 31945437.661665794 49335778.79357541 12040655.397560753 1.0 1.5443763618483104 0.3769131456292245 24.92910656931554 -6.779914362204464 1.5362015665367976 1.3082776500981872 0.36769215817551243 0.7670702442513275 0.23020186056677977 0.25071776009467633 1.1686630801254512 0.11802640972438343 0.2785130335279638 1.6599141908446256e-07 6.779914362204464 -0.9405854919226748 down TK(ub)EGAVLKPELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKEGAVLKPELK 12 2 Q5VYK3;J3KN16;R4GMY1 Q5VYK3 ECM29;KIAA0368 Proteasome-associated protein ECM29 homolog 1 9460490.0 620890.0 1773200.0 7066400.0 True False 813992.8027073122 1508645.4718794657 6335236.713695155 1.0 1.853389203027057 7.7829149012428305 19.634656512731315 -6.932815279005565 0.723307922389315 0.9185729444632444 9.092353297064479 0.997063222906899 0.16347231410460752 0.09120219108103564 0.07071006337881093 0.15150800246140406 0.5284600679221084 1.1673060085314412e-07 6.932815279005565 8.173780352601234 TK(ub)EGAVLKPELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKEGAVLKPELK 12 2 Q5VYK3;J3KN16;R4GMY1 Q5VYK3 ECM29;KIAA0368 Proteasome-associated protein ECM29 homolog 1 14153100.0 622100.0 3409000.0 10122000.0 True False 602351.776020324 4770231.477700146 7470744.546508945 1.0 7.919344920366257 12.402627241953834 19.20024674763187 -8.219210908513313 0.3716370384358703 3.29803942683835e-17 13.981402089939273 0.9974513291748472 0.2367908914384623 0.10729549923060948 0.09800610567560049 0.9342475830584791 1.1563915543901777 6.036554021117482e-09 8.219210908513313 13.981402089939273 TK(ub)EGAVLKPELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKEGAVLKPELK 12 2 Q5VYK3;J3KN16;R4GMY1 Q5VYK3 ECM29;KIAA0368 Proteasome-associated protein ECM29 homolog 1 16045200.0 1257800.0 6275800.0 8511600.0 True False 1908174.5574972187 5155834.456950799 6829278.52923319 1.0 2.7019721213101406 3.5789590121097423 20.863761722699326 -8.958901016778963 0.24572820094244224 6.712635294353175e-22 4.2104564967835305 0.9992088481732199 0.03011494687377492 0.4389153184940683 0.08178652896928232 0.7498656468521276 0.3729662247429205 1.0992563504110842e-09 8.958901016778963 4.2104564967835305 TK(ub)EGAVLKPELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKEGAVLKPELK 12 2 Q5VYK3;J3KN16;R4GMY1 Q5VYK3 ECM29;KIAA0368 Proteasome-associated protein ECM29 homolog 1 8512490.0 620890.0 2332300.0 5559300.0 True False 850449.8119213482 2229251.2741152816 4246307.837377462 1.0 2.621261411157145 4.993014023701344 19.697866574254206 -6.965670029922605 0.34636037381792983 0.7609842633769297 6.932877660600664 0.9999262984152084 0.014076853860398747 0.07773431101794333 0.014062339353507142 0.03286990015205206 0.20436044357541938 1.0822559199271415e-07 6.965670029922605 6.171893397223735 TK(ub)EGAVLKPELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKEGAVLKPELK 12 2 Q5VYK3;J3KN16;R4GMY1 Q5VYK3 ECM29;KIAA0368 Proteasome-associated protein ECM29 homolog 1 13918600.0 622100.0 7822500.0 5474000.0 True False 517303.71370284725 7780358.639855327 6618588.09108366 1.0 15.040214160002277 12.794395083128187 18.980652023066146 -9.181340203752058 13.141898424746708 1.0000000037934822 13.917304621568693 0.9778317640838154 0.9168517988249798 0.0 0.0 0.8877379369473644 0.2959126456491214 6.586577348268098e-10 9.181340203752058 12.91730461777521 TK(ub)EGAVLKPELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKEGAVLKPELK 12 2 Q5VYK3;J3KN16;R4GMY1 Q5VYK3 ECM29;KIAA0368 Proteasome-associated protein ECM29 homolog 1 10658200.0 1257800.0 6912900.0 2487500.0 True False 1628246.894944692 6528191.03807252 2034800.5239053739 1.0 4.009337317541311 1.2496879497961466 20.634888044791776 -6.625535373749486 2.0963018582311124 2.988931704507852 1.2604845650163483 0.10182750625889203 1.2922902197103037 0.5706740826005644 4.772804542425737 0.5051841901352778 1.4323407245171094 2.3684522109647627e-07 6.625535373749486 -1.7284471394915037 TK(ub)EGYYYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKEGYYYR 8 1 P08243-2;P08243;P08243-3 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 7851040.0 1281500.0 819640.0 5749900.0 True False 1658927.0121415334 774026.313478535 4703477.19895618 1.0 0.466582500503945 2.8352526449517463 20.66181898271991 -6.847552125452187 1.2467867824826062 0.7158260505710892 2.9255918287138023 0.9366712711782791 0.2553063623321579 0.16017437020739625 0.4803608588594627 0.16032577321330815 0.370482550817409 1.4205217069404407e-07 6.847552125452187 2.209765778142713 up TK(ub)EQILEEFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKEQILEEFSK 11 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 6665000.0 2016900.0 2344300.0 2303800.0 True False 1952874.6134952416 3280391.215363 1700365.6674814587 1.0 1.6797756459600743 0.8706988435054496 20.897167891669334 -6.683893132423207 1.887985035366919 1.428595785865172 0.8736783487536948 0.34199678464766126 0.2878644240645635 0.42997073064431873 2.966407940427019 0.12219394587299413 0.3206881185385286 2.070650814649713e-07 6.683893132423207 -0.5549174371114773 TK(ub)EQILEEFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKEQILEEFSK 11 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 24444600.0 6073000.0 8205600.0 10166000.0 True False 9213184.995770859 6741246.5693545705 8156685.64408391 1.0 0.731695561572791 0.8853274570985045 23.135268551185955 -10.178589067934045 5.085936427800706 1.000012720332999 0.8085115095687716 0.6744142285814911 0.06271995870974537 9.047016110606298e-06 1.461148391402849e-06 0.060732371431015474 0.020242779629711802 6.628433935002004e-11 10.178589067934045 -0.19150121076422733 TK(ub)EQILEEFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKEQILEEFSK 11 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 10271800.0 2016900.0 5587900.0 2667000.0 True False 1677141.7138197576 5557796.873588689 3224657.369185263 1.0 3.3138504801306166 1.92271013392242 20.67757316710361 -10.224870345570412 6.021450116154365 0.9999651944088324 2.618280307026526 0.6434024431578891 0.5679306681348293 0.0002653728152876521 3.4160709294889605e-05 0.5499081990364296 0.1832988349572165 5.958399992651137e-11 10.224870345570412 1.6183151126176936 TK(ub)FENLCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKFENLCK 8 1 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 1 3601700.0 2376080.0 718600.0 507020.0 True False 3115063.889991452 611387.6810808608 454558.4340792647 1.0 0.19626810321458238 0.14592266808386778 21.570830322566575 -13.565867682145795 0.3979863790536859 9.999992024163845 0.14276321485862253 0.9998261463189311 0.005159289997049815 18.509964226357813 0.20711118424378333 141.8104400178869 0.012958408900168002 2.717267020953194e-14 13.565867682145795 -9.857228809305223 TK(ub)FENLCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKFENLCK 8 1 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 1 4018250.0 2376080.0 776500.0 865670.0 True False 3254580.9871476097 742191.6624578803 661216.5750332862 1.0 0.22804522775398942 0.2031648859390627 21.634040384089467 TK(ub)FENLCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKFENLCK 8 1 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 1 3129280.0 975350.0 757930.0 1396000.0 True False 1262609.8020228199 715750.5292259841 1141942.324169607 1.0 0.5668818094705778 0.9044301116149326 20.267977425660334 -10.443266452856157 6.2488565559825755 1.0000877448116743 0.7356559605427553 0.4498610079308789 0.13780351729941243 0.00016851065714459335 1.501314246570377e-05 0.1334717569025764 0.04447589396245248 3.6035748492226916e-11 10.443266452856157 -0.264431784268919 TK(ub)GDFILVGDLMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKGDFILVGDLMR 13 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 26316500.0 7414000.0 6310500.0 12592000.0 True False 7178646.628218417 8830315.558822762 9293777.448097276 1.0 1.2300808238856373 1.2946420027926333 22.775280451423146 -13.515146269741669 0.18396231916053765 1.0656567831520656e-19 1.3448989147829853 0.9994809278895657 0.0028810523615953 10.145172240704982 0.1327859103648486 3.664379814034201 0.04661610576907401 3.0538923935306905e-14 13.515146269741669 1.3448989147829853 TK(ub)GDFILVGDLMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKGDFILVGDLMR 13 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 21969800.0 7414000.0 4582400.0 9973400.0 True False 6165069.495889576 4557713.7016648175 12058791.828208607 1.0 0.739280182438101 1.9559863576961363 22.555685726857423 -6.850651475265574 1.2319295234401342 0.8607900382503354 2.0052444269979137 0.9412521388423838 0.12677733296830082 0.156739413430468 0.4574229980443392 0.08051296124934397 0.18639245283366815 1.4104202176825443e-07 6.850651475265574 1.1444543887475782 TK(ub)GDFILVGDLMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKGDFILVGDLMR 13 1 Q16531;F5GY55;Q16531-2 Q16531 DDB1 DNA damage-binding protein 1 1 32717500.0 6891600.0 16591000.0 9234900.0 True False 8921312.053745285 15667696.265338887 7554242.958075866 1.0 1.756209868117031 0.8467636724919285 23.088824471648156 -6.686022571056258 1.8809532454884628 1.4758585996047555 0.850081684793844 0.3517405538501873 0.32008710906961335 0.42524865368099096 2.913891562089392 0.13630925109099473 0.35669565494809063 2.060522821453183e-07 6.686022571056258 -0.6257769148109115 TK(ub)GTSSFGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKGTSSFGKR 10 2 P61927;D6RG19;D6R9X9 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 2 8045910.0 902310.0 2462100.0 4681500.0 True False 1182937.1479824684 2094764.2771906308 4197103.2881189715 1.0 1.7708162101116771 3.5480357475266087 20.173941991520156 -6.9571723717413665 0.47361332536967693 0.9546696902983886 4.437483510050804 0.9996504958702804 0.019946380938201284 0.08072723320613587 0.024984897791883027 0.024742892698415977 0.1466491068469652 1.1036404973843389e-07 6.9571723717413665 3.482813819752415 TK(ub)GTSSFGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKGTSSFGKR 10 2 P61927;D6RG19;D6R9X9 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 2 6240900.0 0.0 2832300.0 3408600.0 True False 0.0 3963252.1602493757 2515785.404191903 0.0 TK(ub)GTSSFGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKGTSSFGKR 10 2 P61927;D6RG19;D6R9X9 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 2 7401510.0 902310.0 1587800.0 4911400.0 True False 1235918.3910108902 1517645.745847553 3751428.4734581094 1.0 1.227949803875182 3.0353367186240487 20.237152053043047 -6.930262658971676 0.7446361156915411 0.9727812700541342 3.4088741520143877 0.9965895653488043 0.05317262120113221 0.09250169184732214 0.07701453601683059 0.0485186788326049 0.16330180841564024 1.1741871980359768e-07 6.930262658971676 2.4360928819602536 up TK(ub)GTSSFGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKGTSSFGKR 10 2 P61927;D6RG19;D6R9X9 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 2 4748100.0 0.0 2226400.0 2521700.0 True False 0.0 2214405.9412942007 3048975.810976562 0.0 TK(ub)HPQLHIESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKHPQLHIESK 11 1 B0QY36;B0QY35;B0QY34;H7BYT1;P48730-2;P48730;P49674;B4DLF1 B0QY36 CSNK1E;CSNK1D Casein kinase I isoform delta;Casein kinase I isoform epsilon 1 1777540.0 449560.0 566830.0 761150.0 True False 615774.4809021909 541785.5763438513 581382.0463763168 1.0 0.8798441526028553 0.9441476780988315 19.232042554488068 -10.170161935693743 4.462936160674549 1.000017417607564 0.9119959153486574 0.7140670588002063 0.026251804361948544 4.550469130230906e-06 8.461298205681115e-07 0.025423230334965328 0.008472733424103634 6.758309308428647e-11 10.170161935693743 -0.08802150225890659 TK(ub)IYHPNIDEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKIYHPNIDEK 11 1 A0A1B0GUS4;P68036-2;P68036;P68036-3 A0A1B0GUS4;P68036-2 UBE2L3 Ubiquitin-conjugating enzyme E2 L3 1 10869700.0 2693300.0 3459000.0 4717400.0 True False 3486529.942880052 3266503.6092946273 3858881.6046115346 1.0 0.9368924583496702 1.1067972074904657 21.733360441099197 -6.80616553813025 1.4309041132354439 0.9654478774236989 1.1095071051478058 0.8494890564214821 0.027204955318799424 0.2120837866329738 0.8565809985498386 0.014953672063573526 0.034649888912566304 1.5625519380216217e-07 6.80616553813025 0.14405922772410695 TK(ub)PIWTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKPIWTR 7 1 P08238;P07900;P07900-2;Q14568;Q58FG0;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AA5P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 2 1 38128600.0 12727000.0 19577000.0 5824600.0 True False 16685220.248443304 16656187.91054833 5221926.265508437 1.0 0.998259996723886 0.3129671762046792 23.992067394737745 -6.907453467152807 0.9128798916527576 1.0229649254241555 0.2290579974598055 0.9899249814200131 0.03246720437014449 0.10612712385895107 0.14807193040066657 0.026251013214599397 0.07124962584075276 1.237503776214144e-07 6.907453467152807 -0.79390692796435 down TK(ub)PIWTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKPIWTR 7 1 P08238;P07900;P07900-2;Q14568;Q58FG0;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AA5P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 2 1 40202300.0 15363000.0 16486000.0 8353300.0 True False 14875309.97428103 23068945.773354255 6165320.136371592 1.0 1.5508211804150487 0.4144666663774569 23.82641639607404 -6.774902007992022 1.5556133255828006 1.3139631837268122 0.40684921021421955 0.7489369935924797 0.23248616273564418 0.2586005768544756 1.2356232777195932 0.11775202809741427 0.27906641569246426 1.6791828576992077e-07 6.774902007992022 -0.9071139735125926 down TK(ub)PIWTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKPIWTR 7 1 P08238;P07900;P07900-2;Q14568;Q58FG0;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AA5P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 2 1 83402000.0 29992000.0 23777000.0 29633000.0 True False 45500056.70890163 19533808.57945107 23776024.56139471 1.0 0.4293139391984423 0.5225493390812229 25.439365007623973 -10.814277110430499 7.307980384115971 1.0230212397268794 0.47593163913983316 0.9768122732255297 0.03806319261285984 0.01295945475494755 0.0003293473753792795 0.03345372034163273 0.01228484259109095 1.5336381015402817e-11 10.814277110430499 -0.5470896005870463 TK(ub)PIWTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKPIWTR 7 1 P08238;P07900;P07900-2;Q14568;Q58FG0;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AA5P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 2 1 30886600.0 12727000.0 11203000.0 6956600.0 True False 17432515.83424278 10708014.416633159 5313594.355674278 1.0 0.6142552525665488 0.3048093807112314 24.055277456260637 -7.756516709001988 0.24729280859472846 1.1571024199269582 8.70382461177666e-10 0.9997554717041678 0.004446953790762433 0.12533724180008943 0.03492757625621483 0.04546060209188387 0.0834342239365275 1.7517950345269624e-08 7.756516709001988 -1.1571024190565757 down TK(ub)PIWTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKPIWTR 7 1 P08238;P07900;P07900-2;Q14568;Q58FG0;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AA5P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 2 1 46490200.0 15363000.0 24925000.0 6202200.0 True False 12775015.196297755 24790724.07777484 7499051.344267281 1.0 1.940563177174089 0.5870091916947803 23.606821671508317 -6.719857065236463 1.760113870256772 1.5723314230445053 0.5891799448721492 0.5116861679804801 0.3958005437971838 0.3556097878179191 2.1530251946149184 0.17856764725574523 0.44829882391598586 1.906087945368485e-07 6.719857065236463 -0.9831514781723562 TK(ub)PIWTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKPIWTR 7 1 P08238;P07900;P07900-2;Q14568;Q58FG0;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AA5P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-alpha A5;Putative heat shock protein HSP 90-beta 2 1 88853000.0 29992000.0 31681000.0 27180000.0 True False 38825235.23070528 29917924.500162788 22233518.890350938 1.0 0.7705793492914096 0.57265638593652 25.210491329716422 -6.972848388453205 0.1774103525667385 1.1583578417029408 0.17953939286737183 0.9999969231432799 0.00030624635680046453 0.07538881899463036 0.005578757401922429 0.007799291277197313 0.022389051535644387 1.0645145737935136e-07 6.972848388453205 -0.9788184488355689 TK(ub)QIQNMEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKQIQNMEQK 10 1 B5MCA1;Q96G28;Q96G28-2 B5MCA1 CFAP36 Cilia- and flagella-associated protein 36 1 2435640.0 841540.0 1594100.0 0.0 True False 1103267.0894849512 1356266.4937531312 0.0 1.0 1.22931836422882 0.0 20.073350663997456 -6.905183968752465 1.2880882984742104 1.1196350637846686 2.549412879228236e-22 0.9503787696225936 0.11889277793202303 0.1311569214680674 0.43647942323072597 0.07552102953832902 0.14970506804398587 1.2439875424105688e-07 6.905183968752465 -1.1196350637846686 down TK(ub)QIQNMEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKQIQNMEQK 10 1 B5MCA1;Q96G28;Q96G28-2 B5MCA1 CFAP36 Cilia- and flagella-associated protein 36 1 4830700.0 1487100.0 2099000.0 1244600.0 True False 1439892.8244973845 2937141.646140394 918601.9228003395 1.0 2.0398335182798384 0.637965484077602 20.45753000090811 -6.708064432779675 1.8022821748379327 1.6405291910114916 0.6414671547412617 0.4558466048164851 0.43831473704602675 0.37896744527749715 2.398383725472491 0.19363316876494027 0.4930445597219747 1.958554077032116e-07 6.708064432779675 -0.9990620362702299 TK(ub)QIQNMEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKQIQNMEQK 10 1 B5MCA1;Q96G28;Q96G28-2 B5MCA1 CFAP36 Cilia- and flagella-associated protein 36 1 2214940.0 841540.0 0.0 1373400.0 True False 1152680.0797633901 0.0 1049031.2060608708 1.0 0.0 0.9100801032982236 20.136560725520347 -10.834447900855077 12.408664237057124 1.004809325517003 0.4550400516491119 0.32345071061789565 0.37153864635667566 0.04894494446445371 0.000653004799211371 0.3561901974205268 0.11991358248432092 1.4640371568879286e-11 10.834447900855077 -0.5497692738678911 TK(ub)SAPSRDPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKSAPSRDPER 11 2 F5H6W4;Q9H992;Q9H992-2 F5H6W4 MARCH7 E3 ubiquitin-protein ligase MARCH7 1 7349700.0 1583400.0 2812300.0 2954000.0 True False 2075852.7336674137 2392715.8022595383 2648348.416768864 1.0 1.1526423640044647 1.2757881972147518 20.985272668153023 -6.973563487606781 0.15039237243020281 0.8576311420011696 1.5740393815265645 0.9999985253277099 0.00013686365998821814 0.07516237170606702 0.004598620582873695 0.00626024201697191 0.015337744518085998 1.0627632112236666e-07 6.973563487606781 0.7164082395253949 TK(ub)SAPSRDPER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKSAPSRDPER 11 2 F5H6W4;Q9H992;Q9H992-2 F5H6W4 MARCH7 E3 ubiquitin-protein ligase MARCH7 1 9674700.0 1889100.0 2870200.0 4915400.0 True False 1829131.5545410584 4016285.827895269 3627909.2811608477 1.0 2.1957337174159584 1.983405333615337 20.802727409451094 -10.115365606162113 4.666034241093376 0.9999188085132239 2.089569525533163 0.9723069451296378 0.08668269976351611 7.322090645824849e-05 1.3881674047712297e-05 0.0839363507287348 0.027976721040554754 7.667157661394247e-11 10.115365606162113 1.0896507170199392 TK(ub)SAPSRDPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKSAPSRDPER 11 2 F5H6W4;Q9H992;Q9H992-2 F5H6W4 MARCH7 E3 ubiquitin-protein ligase MARCH7 1 6714900.0 1583400.0 2430900.0 2700600.0 True False 2168825.769776072 2323494.8000886845 2062773.9006028764 1.0 1.0713146406078446 0.9511017110497791 21.048482729675914 -6.746024650681927 1.6649544898085273 1.0421342145448809 0.9509390688403601 0.6315280081665677 0.02996264757442341 0.3070289020955466 1.673325423760543 0.014225094828636332 0.03467469402748096 1.7946317601175007e-07 6.746024650681927 -0.09119514570452081 TK(ub)SAPSRDPER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKSAPSRDPER 11 2 F5H6W4;Q9H992;Q9H992-2 F5H6W4 MARCH7 E3 ubiquitin-protein ligase MARCH7 1 6231600.0 1889100.0 2335000.0 2007500.0 True False 1570870.3513197994 2322420.8915387895 2427258.9683687342 1.0 1.4784293876242296 1.5451682351311946 20.58313268488537 -11.779236042216114 0.32434299180345993 6.720681381980471e-10 1.5591727504975277 0.999499255727552 0.005433161120757984 4.6267779372099795 0.17234095950930886 3.185615816652701 0.021825860463214306 1.662508819113193e-12 11.779236042216114 1.5591727498254595 TK(ub)SGFWGWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKSGFWGWR 9 1 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 20826000.0 4620000.0 8751200.0 7454800.0 True False 6056864.740143642 7445555.071910434 6683448.807491032 1.0 1.2292754405695807 1.1034502327903282 22.53013976329638 -10.3153852270153 5.255691668951069 0.9999580324959946 1.1663628366799264 0.6997771687405263 0.05136792597318627 2.526774699829305e-05 3.291276634973567e-06 0.04974931446785269 0.01657892681860719 4.8374308840457645e-11 10.3153852270153 0.16640480418393178 TK(ub)SGFWGWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKSGFWGWR 9 1 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 36971600.0 10210600.0 11574400.0 15186600.0 True False 9886470.091999864 16196118.279698633 11208773.87176575 1.0 1.6382104157483406 1.133748827181088 23.23702407617338 -10.117844439475201 4.348233696335018 0.9999452714084173 1.3859796214936229 0.4383817650938704 0.20594558123676668 143609200.25426322 9.4670730424489 80994.43344333196 0.07050065027393823 7.623520290249627e-11 10.117844439475201 0.3860343500852056 TK(ub)SGFWGWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKSGFWGWR 9 1 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 28999300.0 4620000.0 16795300.0 7584000.0 True False 6328138.850805509 16053228.11137004 5792815.397382887 1.0 2.5368008651274496 0.9154058616532283 22.59334982481927 -6.658251595173447 1.9787995093038506 1.9906132446537725 0.9221350846532378 0.22835534681460867 0.6546035712831878 0.488574943531591 3.675671051732239 0.26741969573005475 0.7256633982045543 2.1965869788925448e-07 6.658251595173447 -1.0684781600005349 TK(ub)SGFWGWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKSGFWGWR 9 1 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 36105400.0 10210600.0 15771800.0 10123000.0 True False 8490566.306275982 15686834.1829428 12239672.49653635 1.0 1.8475604120007336 1.4415613817760466 23.017429351607657 -10.122326394724674 4.503268978955458 0.9999351803329408 1.6445608967240606 0.7706736911662391 0.16574841014284686 87408258.93244241 9.474741110177499 65186.01681879947 0.06065770706079097 7.545249500687474e-11 10.122326394724674 0.6446257163911198 TK(ub)SLLVNPVLFPNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKSLLVNPVLFPNR 14 1 Q9BUB7;Q9BUB7-2 Q9BUB7 TMEM70 Transmembrane protein 70, mitochondrial 1 4125020.0 1007000.0 763820.0 2354200.0 True False 975033.3362039311 1068817.3092686783 1737564.3955138684 1.0 1.0961854016498283 1.782056398480361 19.895092019610775 -6.932300914908567 0.727655835784696 0.9904089253803953 1.9314849100550657 0.9969715127069246 0.019162857576020372 0.09146038460133014 0.07195490746822497 0.017703693096563805 0.06129308722095749 1.1686893463942754e-07 6.932300914908567 0.9410759846746705 TK(ub)SLSFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKSLSFR 7 1 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 19271900.0 2793500.0 5640400.0 10838000.0 True False 2704821.871584589 7892641.134297421 7999202.666969367 1.0 2.9179892462469654 2.9573861225408997 21.36710215655802 -10.597875463528576 0.7212587490765243 7.906474021423624e-16 2.9501758200052217 0.9999520399073476 0.006326808097679529 2.093397046875214 0.36965635572465433 3.8207960762464026 0.006023719571095245 2.5242044990468368e-11 10.597875463528576 2.950175820005221 TK(ub)SLSFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKSLSFR 7 1 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 13866200.0 2793500.0 10775000.0 297700.0 True False 2322919.023033117 10716952.936329966 359947.6935907209 1.0 4.613571471956205 0.1549549037317386 21.147507431992295 -6.69107857063237 1.8623004687781892 3.263141751935063 0.1700389575385378 0.37560738588504117 1.5279470344617698 0.4143542562854453 2.7869458947445462 0.6561124316164951 1.7064212981121534 2.0366735784181829e-07 6.69107857063237 -3.0931027943965255 TK(ub)STGGAPTFNVTVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKSTGGAPTFNVTVTK 16 1 P07737;K7EJ44 P07737 PFN1 Profilin-1 1 25719300.0 3311800.0 5265500.0 17142000.0 True False 5024242.725011349 4325830.385460722 13753876.186394485 1.0 0.8609915209562156 2.7375023340185893 22.260474732938935 -6.889060127093294 1.0278900900857009 0.8968898231268241 2.895980479510253 0.9802911947876927 0.11985199650231043 0.11991051304404585 0.2263104049210824 0.08894806031635848 0.22101941978523024 1.2910405195863517e-07 6.889060127093294 1.999090656383429 up TK(ub)TIELIEFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKTIELIEFEK 11 1 Q9NW08;Q9NW08-2 Q9NW08 POLR3B DNA-directed RNA polymerase III subunit RPC2 1 6075400.0 760500.0 2051500.0 3263400.0 True False 736358.3437766529 2870674.64843117 2408617.6400985303 1.0 3.89847507357353 3.2709857373858933 19.490048489328487 -9.346448240322815 8.867139871437596 0.9999999991266639 3.5847304054800446 0.9576689663149356 0.25617144878412085 0.0 0.0 0.2480369387281359 0.08267897957604528 4.5035165147748407e-10 9.346448240322815 2.5847304063533807 TK(ub)TIELIEFEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKTIELIEFEK 11 1 Q9NW08;Q9NW08-2 Q9NW08 POLR3B DNA-directed RNA polymerase III subunit RPC2 1 2675100.0 760500.0 0.0 1914600.0 True False 632389.4458624253 0.0 2314934.0078898016 1.0 0.0 3.6606145517384387 19.270453764762763 -6.833894435283711 1.3102864249652053 0.4669167501851247 3.7672840686739657 0.9134624299492063 0.4544517768448445 0.1760551269721017 0.5897298859221437 0.27219283961003077 0.626473568583271 1.465904117521332e-07 6.833894435283711 3.300367318488841 TK(ub)TISQTSAPVWDESASFLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKTISQTSAPVWDESASFLIR 21 1 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 12524600.0 4568900.0 3306100.0 4649600.0 True False 4423862.7703894125 4626242.971083741 3431730.274989922 1.0 1.0457473957033512 0.7757316293714605 22.076875202738265 -6.863292005088877 1.1689116303506628 1.0250749670319081 0.7618047071786019 0.9575222247285715 0.024318179576863493 0.14345343027050816 0.3705895243374248 0.016202444109854174 0.0379748212627684 1.369960340903572e-07 6.863292005088877 -0.2632702598533062 TK(ub)TISQTSAPVWDESASFLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKTISQTSAPVWDESASFLIR 21 1 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 12430600.0 4568900.0 4680000.0 3181700.0 True False 3799242.7865888677 4654787.911092731 3846978.759481349 1.0 1.2251883263485803 1.0125646018361836 21.85728047817254 -10.407056912171704 3.3006175007024434 0.9986908180919079 1.1188764640925712 0.29417418944070417 0.0868032726191494 62751704.69565024 67898445.61216673 746379.4261745589 0.031766736785377093 3.91690544610713e-11 10.407056912171704 0.1201856460006634 TK(ub)VSSYPVALIPGQFQEYYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKVSSYPVALIPGQFQEYYK 20 1 Q8WUB8-3;Q8WUB8-2;Q8WUB8;S5FZ81 Q8WUB8-3 PHF10 PHD finger protein 10 1 25330100.0 7557200.0 8086600.0 9686300.0 True False 7317300.822602146 11315621.551061906 7149167.44722877 1.0 1.5464201657678869 0.9770224869183954 22.802880140241086 -6.6555436794316645 1.9890200570549 1.353007980782585 0.9794229946531461 0.21677658107051756 0.2329034662663888 0.4950511977208052 3.76020186456218 0.09476695569161624 0.25802651158846057 2.2103259402439984e-07 6.6555436794316645 -0.3735849861294389 TK(ub)VSSYPVALIPGQFQEYYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKVSSYPVALIPGQFQEYYK 20 1 Q8WUB8-3;Q8WUB8-2;Q8WUB8;S5FZ81 Q8WUB8-3 PHF10 PHD finger protein 10 1 22304000.0 7557200.0 9901900.0 4844900.0 True False 6284146.64072522 9848556.49932673 5857946.189713416 1.0 1.567206665023043 0.9321784682346912 22.583285415675363 -6.671194833136153 1.9332356032895606 1.361678195313676 0.9347382598297237 0.2842863605449899 0.2408718422758755 0.4583934958879624 3.3040537254255042 0.1002675987512665 0.26746363169559495 2.1320882014204207e-07 6.671194833136153 -0.42693993548395237 TKDGQILPVPNVVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKDGQILPVPNVVVR 15 1 Q9P258 Q9P258 RCC2 Protein RCC2 0 7042500.0 2057300.0 2471200.0 2514000.0 False True 2697140.22292154 2102506.5926621538 2253875.3959908313 1.0 0.7795318073543541 0.8356537701808604 21.362999097814534 -10.15864418064356 5.294365881137723 1.0000067573376188 0.8075927887675237 0.9400180607662818 0.022911695381690408 1.8275178364227418e-06 2.904195601259717e-07 0.02218493251818884 0.007394717887179787 6.939941655909662e-11 10.15864418064356 -0.19241396857009507 TKDGQILPVPNVVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKDGQILPVPNVVVR 15 1 Q9P258 Q9P258 RCC2 Protein RCC2 0 33047200.0 4654600.0 22139000.0 6253600.0 False True 7061368.496840952 18188122.477203477 5017573.218949756 1.0 2.5757220410378396 0.710566687065612 22.75151637495676 -6.6827851567734635 1.8922361090560416 1.9944823725524656 0.7175438174663944 0.3368396485360685 0.6674262378707565 0.43234674144421786 2.995402336271494 0.28279414034780015 0.7431332159172075 2.075940220336113e-07 6.6827851567734635 -1.2769385550860712 TKDGQILPVPNVVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKDGQILPVPNVVVR 15 1 Q9P258 Q9P258 RCC2 Protein RCC2 0 10390700.0 2057300.0 5051300.0 3282100.0 False True 2817939.4064420294 4828116.863584671 2506935.5769713046 1.0 1.7133501354029186 0.8896343091126283 21.426209159337425 -6.677692248909044 1.9103515278925403 1.4522824292785352 0.8928425777121283 0.3134980970065675 0.3024893021179047 0.44365765149887365 3.1284140001767993 0.1271573715683187 0.33633124034277057 2.1004277679691412e-07 6.677692248909044 -0.559439851566407 TKDGVVEITGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKDGVVEITGK 11 1 P04792 P04792 HSPB1 Heat shock protein beta-1 0 27996600.0 4368600.0 13059000.0 10569000.0 False True 5727276.905582572 11110648.10358332 9475421.265006809 1.0 1.9399530154991094 1.6544374265841402 22.44941792669904 -10.036928937009854 4.876746177628614 0.9999839708661836 1.7971952210526105 0.9122392554293672 0.11656125111324313 80630032.39188333 3.775148283704324 14512.85454526881 0.03990201659786025 9.184828742384723e-11 10.036928937009854 0.7972112501864269 TKDGVVEITGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKDGVVEITGK 11 1 P04792 P04792 HSPB1 Heat shock protein beta-1 0 34652000.0 9788900.0 6177100.0 18686000.0 False True 9478156.727672948 8643648.243150957 13791576.032016039 1.0 0.9119545594677165 1.4550905232184435 23.1761750864212 -6.865347620771699 1.1585041163693441 0.9513680989170257 1.484198271544514 0.9598107625972443 0.047715273480763674 0.14138923313113583 0.3576130983359142 0.032048041743276225 0.0753156094563291 1.3634913252275636e-07 6.865347620771699 0.5328301726274882 TKDGVVEITGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKDGVVEITGK 11 1 P04792 P04792 HSPB1 Heat shock protein beta-1 0 134278000.0 13971000.0 102650000.0 17657000.0 False True 21195028.41691336 84331305.4918894 14167086.210661989 1.0 3.9788248372714663 0.6684155327367637 24.33722256487737 -6.669570318849598 1.9385301842807297 2.902033065094727 0.6817151220465946 0.2772869351758154 1.2654580318144186 0.4621141062003951 3.3474412179285196 0.5255658515808388 1.4051547562514939 2.1400783876367187e-07 6.669570318849598 -2.220317943048132 TKDGVVEITGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKDGVVEITGK 11 1 P04792 P04792 HSPB1 Heat shock protein beta-1 0 28892600.0 4368600.0 12526000.0 11998000.0 False True 5983789.476975956 11972559.902057195 9164319.506566444 1.0 2.0008324069762895 1.5315243863154493 22.512627988221933 -10.15415550774621 4.756915908737411 0.9999274364066543 1.766178396651022 0.780399077712403 0.19159419715347487 0.00014745844110023815 2.6219659936197883e-05 0.18552773178868404 0.06183676123126978 7.012041734115679e-11 10.15415550774621 0.7662509602443678 TKDGVVEITGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKDGVVEITGK 11 1 P04792 P04792 HSPB1 Heat shock protein beta-1 0 19323100.0 9788900.0 6080500.0 3453700.0 False True 8139904.071798415 6047743.139615245 4175852.701895439 1.0 0.7429747434700503 0.5130100631484266 22.956580361855476 -6.972442656068994 0.19103834332254352 1.153758417315305 0.09593732784085371 0.9999956944619603 0.00041270427214852107 0.07551778414479705 0.00610197794296752 0.008047283894405873 0.024996989899827526 1.0655095434934383e-07 6.972442656068994 -1.0578210894744513 TKDGVVEITGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKDGVVEITGK 11 1 P04792 P04792 HSPB1 Heat shock protein beta-1 0 48477000.0 13971000.0 14141000.0 20365000.0 False True 18085734.909582026 13354040.919061976 16658778.962545881 1.0 0.7383742483136173 0.9211004720477172 24.108348886969818 -10.055285450425627 5.262694430822747 1.0000018170855747 0.8297373604985314 0.5365319000258388 0.07459766846342462 1.5903994680162235e-06 2.8550751033539597e-07 0.07222965250351558 0.024076293968575843 8.804699728525305e-11 10.055285450425627 -0.17026445658704326 TKDGVVEITGK(ub)HEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKDGVVEITGKHEER 15 2 P04792 P04792 HSPB1 Heat shock protein beta-1 1 18717000.0 5655300.0 8019600.0 5042100.0 True False 7414153.066003099 6823106.940155962 4520391.85923842 1.0 0.9202813698900656 0.6096976713316388 22.82185046938603 -6.945481096075483 0.6064397455416759 1.003454637219733 0.51044898810435 0.9987971469624031 0.005839629972208255 0.08535289221895218 0.04387624746593191 0.005956026422850262 0.026156824723541087 1.1337541869643478e-07 6.945481096075483 -0.493005649115383 TKDGVVEITGK(ub)HEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKDGVVEITGKHEER 15 2 P04792 P04792 HSPB1 Heat shock protein beta-1 1 23297550.0 6277500.0 9668450.0 7351600.0 True False 6078224.198629767 13529112.505300691 5425995.416727448 1.0 2.2258330826873087 0.8926941882056024 22.535218459762852 -6.664886862462105 1.9550848914828454 1.785813546806546 0.8981238121501086 0.25687078166212196 0.5213194453725281 0.47290009756171725 3.479615749451979 0.2150276793546292 0.5784449608738578 2.1632820043447844e-07 6.664886862462105 -0.8876897346564373 TKDGVVEITGK(ub)HEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKDGVVEITGKHEER 15 2 P04792 P04792 HSPB1 Heat shock protein beta-1 1 139653700.0 26811200.0 37990300.0 74852200.0 True False 40674550.56127315 31210634.145431288 60057629.86111534 1.0 0.7673258515398914 1.4765407123710694 25.277623068951264 -6.818318701582161 1.379034007155744 0.8743688944553454 1.4914835760366236 0.880482797264264 0.10204958859740236 0.19568372745191775 0.7316673276800842 0.05815667601652316 0.1341120617607667 1.5194321042366907e-07 6.818318701582161 0.6171146815812782 TKDGVVEITGK(ub)HEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKDGVVEITGKHEER 15 2 P04792 P04792 HSPB1 Heat shock protein beta-1 1 16563800.0 5655300.0 5475100.0 5433400.0 True False 7746217.238736012 5233191.978265476 4150142.8243855718 1.0 0.6755803274011202 0.5357638052844966 22.88506053090892 -13.999999999999948 0.11476117941637291 2.5542627085803713 0.29600107997005043 0.9997189853220264 0.0032597268994389674 11.986817516098212 0.10354433490600982 4.281565433058316 0.2127817903121085 1.0000000000001186e-14 13.999999999999948 -2.2582616286103208 TKDGVVEITGK(ub)HEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKDGVVEITGKHEER 15 2 P04792 P04792 HSPB1 Heat shock protein beta-1 1 23261200.0 6277500.0 12076000.0 4907700.0 True False 5220019.390402859 12010944.19110169 5933877.379359033 1.0 2.300938615895589 1.1367538960235704 22.31562373519713 -6.619581489129892 2.118711860150862 1.8634973959026375 1.1412318062547349 0.0811796835954337 0.5595170528064859 0.5865938082616644 5.003229487300524 0.21705942035451609 0.6202697994550423 2.4011456850691936e-07 6.619581489129892 -0.7222655896479027 TKDGVVEITGK(ub)HEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKDGVVEITGKHEER 15 2 P04792 P04792 HSPB1 Heat shock protein beta-1 1 166872800.0 26811200.0 49780600.0 90281000.0 True False 34707626.92776361 47010265.84933566 73850784.36128682 1.0 1.354464998346828 2.127796997328316 25.048749391043714 -6.958309671351371 0.4586416694915413 0.9771503792699527 2.5362148641156916 0.9997022588386798 0.008125242527157303 0.08031064854957957 0.02340543202295284 0.010478691253908826 0.06389464251000247 1.1007541428066e-07 6.958309671351371 1.559064484845739 up TKEDEK(ub)DDKPIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKEDEKDDKPIR 12 3 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 101600000.0 34840000.0 47691000.0 19069000.0 True False 45675577.391039975 40575688.69806194 17095922.80276421 1.0 0.8883453919078763 0.37429023953877505 25.444919630479188 -6.941662315743372 0.6439216044247619 1.0056453916993813 0.2286172468743911 0.9983735205648903 0.010989214709196168 0.08701662144884678 0.051218859044248444 0.010836973406271076 0.043929889790399426 1.1437673216776425e-07 6.941662315743372 -0.7770281448249902 down TKEDEK(ub)DDKPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKEDEKDDKPIR 12 3 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 102998000.0 34840000.0 49604000.0 18554000.0 True False 47721289.515598305 47412331.261507675 14171927.33162475 1.0 0.9935257773369757 0.2969728495495177 25.50812969200208 -6.908933349480203 0.9029520977372905 1.0223014496421798 0.20897443581338498 0.9905130260660295 0.03213211299682386 0.10512840882884986 0.14261904345691526 0.026168942465892193 0.07171668904459168 1.233294090491918e-07 6.908933349480203 -0.8133270138287949 down TKENDAHLVEVNLNNIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKENDAHLVEVNLNNIK 17 1 Q9NYL9;H0YNJ8;H0YKU1 Q9NYL9 TMOD3 Tropomodulin-3 0 12570600.0 2497700.0 5838000.0 4234900.0 False True 3274508.8877612064 4966993.156345761 3796713.172029268 1.0 1.5168665978920925 1.1594756044852559 21.64284711618152 -10.046176899217528 4.691620282980271 0.9999896667435281 1.338171100955138 0.5441658994037399 0.14590426212134228 101020749.6371575 1.9141785994076992 12362.574010282055 0.04994690974461505 8.991312678362914e-11 10.046176899217528 0.33818143421160995 TKENDAHLVEVNLNNIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKENDAHLVEVNLNNIK 17 1 Q9NYL9;H0YNJ8;H0YKU1 Q9NYL9 TMOD3 Tropomodulin-3 0 8694000.0 2457200.0 2392000.0 3844800.0 False True 2379197.531003277 3347138.074115211 2837731.5384723963 1.0 1.406834880458104 1.1927263295686767 21.18204362468055 -10.172071567942561 4.411718824929799 0.9999332866872169 1.2997806050228433 0.7232854685839487 0.08740944990631139 5.7369384878037954e-05 1.0766057125179925e-05 0.08465263022589384 0.028211278644547574 6.72865764738512e-11 10.172071567942561 0.2998473183356264 TKENDAHLVEVNLNNIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKENDAHLVEVNLNNIK 17 1 Q9NYL9;H0YNJ8;H0YKU1 Q9NYL9 TMOD3 Tropomodulin-3 0 15603100.0 2497700.0 3987100.0 9118300.0 False True 3421167.187804528 3810936.738423459 6964745.337283271 1.0 1.1139288228907218 2.0357804675873705 21.706057177704412 -6.929884422621452 0.7477383450731977 0.9859217627476666 2.224477403348346 0.9965155750679937 0.02737509419603029 0.09269757002041236 0.07797372584818692 0.02492304394724038 0.0834645050376438 1.1752102682149918e-07 6.929884422621452 1.2385556406006795 up TKFENLCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKFENLCK 8 1 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 18007500.0 4140500.0 7325900.0 6541100.0 False True 5428235.596659031 6232904.276134533 5864289.718661749 1.0 1.148237611494011 1.0803307288782935 22.37205190739035 -10.114459147007404 5.240263354407416 0.9999973847163776 1.1142841701862631 0.7906393199490719 0.027722868738984652 8.470719733971341e-07 1.4312382903183848e-07 0.026843166198237386 0.00894751741120926 7.683177260014265e-11 10.114459147007404 0.11428678546988558 TKFENLCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKFENLCK 8 1 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 8866400.0 4078600.0 2399700.0 2388100.0 False True 3949127.0755127626 3357912.724270184 1762584.9685356694 1.0 0.8502923962846108 0.4463226770961306 21.913102361093674 -6.953805268168977 0.5153778919824643 1.007118019713887 0.27161096721746997 0.9994670643327395 0.005398463146072572 0.08199276888698386 0.029909943503801637 0.006161771305393524 0.03335407156894888 1.1122303246772458e-07 6.953805268168977 -0.7355070524964169 down TKFENLCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKFENLCK 8 1 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 81741000.0 15105000.0 53038000.0 13598000.0 False True 22915389.323418237 43572954.5122146 10910349.33978487 1.0 1.9014712731799628 0.4761145091536851 24.449813460951187 -6.735767873873544 1.7020496636806195 1.5389728249461823 0.4760008801699678 0.5858864342214485 0.3788162860996832 0.3255133271465187 1.8498488938082034 0.176188305506221 0.43439869070545806 1.8375202173961542e-07 6.735767873873544 -1.0629719447762145 TKFENLCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKFENLCK 8 1 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 22090700.0 4140500.0 7563200.0 10387000.0 False True 5671354.742805234 7229032.815842177 7933804.526979951 1.0 1.2746571399034836 1.3989258099301396 22.43526196891324 -12.787776134149718 0.11899811845410314 1.2856842411517567e-22 1.6133000861503743 0.9997322532165196 0.002727270342024962 7.770891780373562 0.09421241059572234 2.0266764176488357 0.17492312287845938 1.6301361026390532e-13 12.787776134149718 1.6133000861503743 TKFENLCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKFENLCK 8 1 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 8380900.0 4078600.0 1644100.0 2658200.0 False True 3391536.6126160254 1635242.9069716993 3214017.3298718682 1.0 0.4821539891059505 0.9476581552786985 21.69350763652795 -10.390691926239196 8.651921352061112 1.0000015251144434 0.7149060721923248 0.3333832359592185 0.1900412800438304 5.590920851030479e-06 3.936111341828674e-07 0.18400766235559737 0.061335559391807924 4.067317485491993e-11 10.390691926239196 -0.2850954529221186 TKFENLCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKFENLCK 8 1 P07900;P07900-2;Q58FG0 P07900 HSP90AA1;HSP90AA5P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A5 0 38909000.0 15105000.0 12295000.0 11509000.0 False True 19553720.26406388 11610772.441826373 9414480.092312329 1.0 0.5937884088055011 0.48146746323329587 24.220939783043637 -13.999999999999998 0.18036654649210282 3.110018789133946 0.39258192589012947 0.9994977003384344 0.0049919537517865925 12.209507928830769 0.1346349242447468 9.029196731040445 0.08360239432162199 1.0000000000000041e-14 13.999999999999998 -2.7174368632438166 TKIEECVVCSDK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKIEECVVCSDKK 13 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 23472900.0 4233000.0 7300900.0 11939000.0 True False 5549503.992430305 6211634.178685304 10703666.806974774 1.0 1.1193133993881552 1.9287609886532033 22.403927400311378 -6.93329459000009 0.71923530429514 0.9890683776930103 2.109795012948435 0.9971470792835081 0.022037298744976883 0.0909627545218639 0.06956179946125687 0.020486082921073873 0.0719602425718936 1.1660184168350782e-07 6.93329459000009 1.1207266352554246 TKIEECVVCSDK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKIEECVVCSDKK 13 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 8988800.0 4047900.0 3106700.0 1834200.0 True False 3919401.6302084327 4347221.51122648 1353767.9951794809 1.0 1.1091543866596023 0.345401702327579 21.902201986158452 -6.870667548019155 1.1306279961722874 1.061983694850396 0.3001149439796857 0.9653413695145858 0.06278812785064124 0.1362127788289535 0.32503912290900006 0.04308274341490534 0.1021147938601933 1.3468910032078878e-07 6.870667548019155 -0.7618687508707103 down TKIEECVVCSDK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKIEECVVCSDKK 13 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 150117000.0 19833000.0 85433000.0 44851000.0 True False 30088110.986517992 70186813.65892442 35986180.19110834 1.0 2.332709211634257 1.1960265703364754 24.842690197405524 -6.607355846646339 2.163173200505776 1.891959118324083 1.199977930655234 0.04228721216232867 0.5749607477892673 0.6200444974788604 5.493943067520506 0.2197705962784005 0.6387165363628151 2.469699724850637e-07 6.607355846646339 -0.6919811876688489 TKIEECVVCSDK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKIEECVVCSDKK 13 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 18649500.0 4047900.0 1419600.0 13182000.0 True False 3366008.2023754255 1411952.3330314616 15938295.25331839 1.0 0.419473824227473 4.735073206913333 21.68260726159273 -6.872966727629918 1.1182162228332817 0.6649414207906996 5.002559878231014 0.9675586745308209 0.3444342801852451 0.13404546173863652 0.3114544427279389 0.23858212040295979 0.5679783866958077 1.33977932728876e-07 6.872966727629918 4.337618457440314 up TKIEECVVCSDK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKIEECVVCSDKK 13 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 140361000.0 19833000.0 96685000.0 23843000.0 True False 25674209.466877144 91304394.7570544 19503818.649839494 1.0 3.5562689817128814 0.7596657912681516 24.613816519497973 -6.666220586805432 1.950675360521212 2.6369076629568413 0.7711095695110903 0.2624729895361202 1.08679801498681 0.46984277164123367 3.4429668740947372 0.4491046758353303 1.205881610267632 2.1566487261330954e-07 6.666220586805432 -1.865798093445751 TKIEFVTGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKIEFVTGTK 10 1 J3QQJ0;Q9UHR5-2;Q9UHR5 J3QQJ0 SAP30BP SAP30-binding protein 0 9113700.0 3664200.0 2321700.0 3127800.0 False True 4803801.684163274 1975311.4099157162 2804165.2599761863 1.0 0.4111975347416482 0.5837387644916102 22.195745162670004 -10.886108224854963 11.239116249134284 1.026370640121428 0.4974681496168791 0.91876824505083 0.07043966207995461 0.033425250541355575 0.0003387146936081826 0.048978480962946186 0.022734303179011844 1.2998456201222513e-11 10.886108224854963 -0.528902490504549 TKIEFVTGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKIEFVTGTK 10 1 J3QQJ0;Q9UHR5-2;Q9UHR5 J3QQJ0 SAP30BP SAP30-binding protein 0 8571280.0 2076900.0 733780.0 5760600.0 False True 2010969.9463375816 1026782.1806121486 4251726.045704353 1.0 0.5105905150308908 2.1142663287672105 20.9394600902545 -6.824818476645753 1.3509861100538094 0.7374217412291291 2.1530023283156976 0.8950904542047704 0.21735443563019852 0.1872947066015461 0.670360120892025 0.12638592463843823 0.2909805884535216 1.4968611728701585e-07 6.824818476645753 1.4155805870865685 up TKIEFVTGTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKIEFVTGTK 10 1 J3QQJ0;Q9UHR5-2;Q9UHR5 J3QQJ0 SAP30BP SAP30-binding protein 0 12193400.0 3067100.0 6066500.0 3059800.0 False True 4653014.9350450905 4983885.677219162 2455029.1888420167 1.0 1.0711088932214796 0.5276211710285916 22.1497343871266 -6.873974945343974 1.1128049347308435 1.0413695339728486 0.49328482179283895 0.9684941694919045 0.042811904164200464 0.1331031758216879 0.3056510485206213 0.02977845378928084 0.07103330269035758 1.3366726276042483e-07 6.873974945343974 -0.5480847121800096 TKIEFVTGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKIEFVTGTK 10 1 J3QQJ0;Q9UHR5-2;Q9UHR5 J3QQJ0 SAP30BP SAP30-binding protein 0 6376800.0 3664200.0 1190800.0 1521800.0 False True 5018953.7612817185 1138186.5185509906 1162382.18245481 1.0 0.2267776458375511 0.2315985039395872 22.258955224192896 -10.070350118312886 5.406571971828208 1.0000072565372728 0.22918807488799506 0.9999706637830867 0.001968107080740581 1.7214869977760773e-07 2.9601358703324348e-08 0.001905629416138068 0.0006352038286467942 8.504521466273109e-11 10.070350118312886 -0.7708191816492778 TKIEFVTGTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKIEFVTGTK 10 1 J3QQJ0;Q9UHR5-2;Q9UHR5 J3QQJ0 SAP30BP SAP30-binding protein 0 4601500.0 2076900.0 1216600.0 1308000.0 False True 1727034.3722704425 1210045.9343238077 1581496.7524913093 1.0 0.7006495954872184 0.9157297491492294 20.719865365688776 -9.878864481766975 5.667914775557061 1.0000000847951616 0.8081896732146441 0.5146644305058619 0.08780610504697708 9.406410638587919e-08 1.8551781828080253e-08 0.08501793300723776 0.028339298544934534 1.3217079986008298e-10 9.878864481766975 -0.19181041158051748 TKIEFVTGTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKIEFVTGTK 10 1 J3QQJ0;Q9UHR5-2;Q9UHR5 J3QQJ0 SAP30BP SAP30-binding protein 0 10515800.0 3067100.0 4600900.0 2847800.0 False True 3970421.4115796313 4344855.870483855 2329529.620895566 1.0 1.0943059741246093 0.5867209999678001 21.92086070921905 -6.8587055507805985 1.1922186784406559 1.0510038933892178 0.5627380645314177 0.9520461686426227 0.04827228321633782 0.14814845178489297 0.4008666252492036 0.031595064519680215 0.07365012585964577 1.3845047472738337e-07 6.8587055507805985 -0.4882658288578001 TKPSDEEMLFIYGHYK ddPTM_RPMI8226_Bortezomib_1h_R1 2 TKPSDEEMLFIYGHYK 16 1 P07108;B8ZWD1;A0A0A0MTI5;P07108-3;P07108-2;P07108-4;P07108-5;P07108-6 P07108 DBI Acyl-CoA-binding protein 0 83370400.0 19647100.0 31565200.0 32158100.0 False True 25757538.36278707 26855795.200185888 28830688.294277158 1.0 1.042638268530564 1.1193106999669653 24.618491386487953 -6.9620704030705145 0.4052020395918894 0.9960195925297785 1.168752652136155 0.999839429108276 0.000625503972761534 0.07896966767836672 0.018458529248617482 0.0009864426408982294 0.006411876388848768 1.091263418421435e-07 6.9620704030705145 0.17273305960637664 TKPSDEEMLFIYGHYK ddPTM_RPMI8226_Bortezomib_2h_R1 2 TKPSDEEMLFIYGHYK 16 1 P07108;B8ZWD1;A0A0A0MTI5;P07108-3;P07108-2;P07108-4;P07108-5;P07108-6 P07108 DBI Acyl-CoA-binding protein 0 77153000.0 20917200.0 13655600.0 42580200.0 False True 20253194.93549639 19108352.29301323 31427168.241381165 1.0 0.943473479313791 1.551714104439933 24.271646174876366 -6.884155963825554 1.0563141277170391 0.9625952178489107 1.5984143109184337 0.9768874260874527 0.04171290943869307 0.12401393281955847 0.2505616329676915 0.03029569039362239 0.07410322582179828 1.3057019002854158e-07 6.884155963825554 0.635819093069523 TKPSDEEMLFIYGHYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKPSDEEMLFIYGHYK 16 1 P07108;B8ZWD1;A0A0A0MTI5;P07108-3;P07108-2;P07108-4;P07108-5;P07108-6 P07108 DBI Acyl-CoA-binding protein 0 233982000.0 30687000.0 163020000.0 40275000.0 False True 46554422.520207584 133927807.3189265 32314628.596840374 1.0 2.876800958293346 0.6941258606056979 25.47241488988832 -6.6791277983482775 1.9048256420272067 2.1883856185449866 0.7024518193506663 0.32022109464622217 0.795581896187223 0.4404539690577699 3.0890169144250152 0.3352207064607859 0.8851633541215932 2.093496319216507e-07 6.6791277983482775 -1.4859337991943202 TKPSDEEMLFIYGHYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKPSDEEMLFIYGHYK 16 1 P07108;B8ZWD1;A0A0A0MTI5;P07108-3;P07108-2;P07108-4;P07108-5;P07108-6 P07108 DBI Acyl-CoA-binding protein 0 59098000.0 17771000.0 22375000.0 18952000.0 False True 24341418.943217494 21386398.51576962 14475927.92869203 1.0 0.8786011434115157 0.5947035364890102 24.536909934263004 -6.95687627569584 0.4774308031934166 1.0069818612116592 0.45453775590225526 0.9996362069690617 0.0032393525811878336 0.08083651729680601 0.025402555922434216 0.003982247753928525 0.02342152267656136 1.1043932009626573e-07 6.95687627569584 -0.552444105309404 TKPSDEEMLFIYGHYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKPSDEEMLFIYGHYK 16 1 P07108;B8ZWD1;A0A0A0MTI5;P07108-3;P07108-2;P07108-4;P07108-5;P07108-6 P07108 DBI Acyl-CoA-binding protein 0 36765400.0 18027000.0 13191000.0 5547400.0 False True 14990249.231508164 13119937.4647915 6707335.69172041 1.0 0.8752314429312198 0.4474465759796835 23.83752103429329 -6.948416792825476 0.5759669579363208 1.0051945461989316 0.29647079092409756 0.9990710781952651 0.0072116188835964976 0.08412787391757331 0.038642614772933105 0.007589274674033368 0.0356968074132515 1.1261162026325915e-07 6.948416792825476 -0.708723755274834 down TKPSDEEMLFIYGHYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKPSDEEMLFIYGHYK 16 1 P07108;B8ZWD1;A0A0A0MTI5;P07108-3;P07108-2;P07108-4;P07108-5;P07108-6 P07108 DBI Acyl-CoA-binding protein 0 112913000.0 30687000.0 48524000.0 33702000.0 False True 39724926.43120347 45823596.74397588 27568581.811722156 1.0 1.153522507419472 0.6939869821902893 25.24354121198077 -6.816625534410654 1.3863761272025366 1.0830414734632643 0.684660166352803 0.876448637188701 0.06714208881563916 0.1979063804618729 0.7483196110212922 0.03806568638158609 0.08782544922589416 1.525367418038546e-07 6.816625534410654 -0.39838130711046127 TKPYIQVDIGGGQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKPYIQVDIGGGQTK 15 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 1370636700.0 517441100.0 480114600.0 373081000.0 False True 678370293.006741 408483373.1520533 334478156.9656552 1.0 0.6021539819226638 0.4930613271450132 29.33749775230447 -13.999999999999995 0.18155610506285094 3.074204359672414 0.4077814308740021 0.9994963437495995 0.004889288501552023 12.225241364876927 0.1350875475472413 8.948551934680316 0.08038785726315052 1.0000000000000123e-14 13.999999999999995 -2.666422928798412 TKPYIQVDIGGGQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKPYIQVDIGGGQTK 15 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 909856400.0 233034400.0 234980000.0 441842000.0 False True 225636850.52858138 328808739.4045118 326110325.2241261 1.0 1.4572475135787346 1.4452884112686981 27.74942746395121 -10.177752510067522 5.028380426330066 0.9999668983266999 1.4512679624243054 0.9994735449054074 0.004882283075619399 1.8119535671950086e-06 2.962872651138586e-07 0.004727596286906269 0.0015757500866497097 6.641214232231708e-11 10.177752510067522 0.4513010640976055 TKPYIQVDIGGGQTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKPYIQVDIGGGQTK 15 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 1898555000.0 472794000.0 838590000.0 587171000.0 False True 717263063.8713146 688937062.5664243 471116394.48380774 1.0 0.9605082113778378 0.6568251150993766 29.41792709885927 -6.930839668003378 0.7398673926652993 1.0044772547763845 0.5931262014793075 0.9967006936248924 0.00880640328213187 0.09220426374271404 0.0755614782725441 0.008063487442621744 0.027352333819691686 1.1726281942559152e-07 6.930839668003378 -0.411351053297077 TKPYIQVDIGGGQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKPYIQVDIGGGQTK 15 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 1383695500.0 517441100.0 449850400.0 416404000.0 False True 708753057.9899442 429974521.8716584 318057951.30957574 1.0 0.6066633745342639 0.44875707797522946 29.40070781382736 -13.999999999999998 0.12580754659708768 2.869550614291132 0.21537794415529551 0.9996649875483249 0.004242429444127182 11.945266685631061 0.10986548516118215 5.545045814023752 0.207283973211718 1.0000000000000041e-14 13.999999999999998 -2.6541726701358366 TKPYIQVDIGGGQTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKPYIQVDIGGGQTK 15 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 565951400.0 233034400.0 156690000.0 176227000.0 False True 193778428.77433643 155845879.86947 213075250.9184148 1.0 0.8042478249782872 1.0995818898219594 27.529832739385487 -6.727962799981216 1.730325551825805 0.8819328419036535 1.0993525661436694 0.5499323739780198 0.08230371585869446 0.34007603230464634 1.9937244542759975 0.037705699656569766 0.09379258811227918 1.8708423827684277e-07 6.727962799981216 0.21741972424001588 TKPYIQVDIGGGQTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TKPYIQVDIGGGQTK 15 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 1841552000.0 472794000.0 877520000.0 491238000.0 False True 612041153.1630468 828685240.5979253 401837724.52752835 1.0 1.3539698046695967 0.6565534399947113 29.18905342095172 -6.768710077037574 1.579257887416178 1.2033588043406926 0.6528073192200079 0.7256676867707414 0.14913221563113394 0.26851125176043034 1.3214235663453475 0.07444038884470841 0.17741916512745412 1.7032952016209598e-07 6.768710077037574 -0.5505514851206847 TKTETITGFQVDAVPANGQTPIQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKTETITGFQVDAVPANGQTPIQR 24 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 13134300.0 2756100.0 5362900.0 5015300.0 False True 3613273.790110369 4562776.224420475 4496364.866154665 1.0 1.262781756784919 1.2444019267129274 21.784875146172862 -10.046196633851373 4.5473410141992625 0.9999884111734684 1.25359184176402 0.996075663102366 0.00750353425735867 8.873919235927026e-07 1.86120472270843e-07 0.007265599778581603 0.0024217552639942373 8.990904116340029e-11 10.046196633851373 0.25360343059055157 TKTETITGFQVDAVPANGQTPIQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKTETITGFQVDAVPANGQTPIQR 24 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 8597100.0 3884900.0 1880800.0 2831400.0 False True 3761575.975986745 2631813.2482424285 2089771.39982073 1.0 0.6996570759286725 0.555557408161226 21.84290579941364 -13.999999999999924 0.09717104603884953 2.4963988905573165 0.23472212075866963 0.9998078012591768 0.0025667310355335007 12.102579605275098 0.09224861338882394 3.659038576547815 0.28664464882919 1.0000000000001759e-14 13.999999999999924 -2.2616767697986466 TKTETITGFQVDAVPANGQTPIQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKTETITGFQVDAVPANGQTPIQR 24 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 12310900.0 2756100.0 4535900.0 5018900.0 False True 3775104.650801965 4335488.939784556 3833539.1874901075 1.0 1.1484420541463785 1.0154789183594497 21.848085207695753 -10.759417913370056 2.9106911040772374 0.9836691746042255 1.081960486267371 0.33626412921947946 0.054281973594142566 30985912.744115256 31039788.74712651 3658956.103216807 0.021456832761423003 1.740131571749198e-11 10.759417913370056 0.09829131166314553 TKVEAFQTTISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TKVEAFQTTISK 12 1 A0A087X1Z3;Q9UL46;H0YM70 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 0 14916400.0 4463600.0 5384400.0 5068400.0 False True 5851822.825563881 4581068.50822681 4543970.587525829 1.0 0.7828447040833604 0.7765051545435285 22.48045465928078 TKVEAFQTTISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TKVEAFQTTISK 12 1 A0A087X1Z3;Q9UL46;H0YM70 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 0 10740500.0 3686200.0 1665600.0 5388700.0 False True 3569183.5987238646 2330682.765989252 3977237.812465202 1.0 0.6530016463211841 1.1143270449542675 21.767162684820295 -6.705488881857626 1.8116929729919586 0.7856928752434902 1.1130872229292164 0.4435037573568277 0.14633084895211337 0.384198076217044 2.455319681842862 0.06435210827371297 0.16436017986075316 1.9702036447082628e-07 6.705488881857626 0.3273943476857262 TKVEAFQTTISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TKVEAFQTTISK 12 1 A0A087X1Z3;Q9UL46;H0YM70 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 0 13277200.0 4463600.0 4678300.0 4135300.0 False True 6113913.544254424 4471597.236930723 3158627.309176876 1.0 0.7313805150439077 0.5166293710752926 22.543664720803672 -7.028136229263289 0.14983357824507146 1.2540231876846202 9.389267700268814e-10 0.9999986413108581 0.00023042282878372303 0.07201504992523786 0.004582575965325989 0.011192173486521372 0.026339174025902252 9.372679590924267e-08 7.028136229263289 -1.2540231867456935 TKVEAFQTTISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TKVEAFQTTISK 12 1 A0A087X1Z3;Q9UL46;H0YM70 A0A087X1Z3 PSME2 Proteasome activator complex subunit 2 0 9162600.0 3686200.0 3300000.0 2176400.0 False True 3065238.6263485514 3282222.245001289 2631475.177463373 1.0 1.0707884915672026 0.8584895005705 21.54756796025457 -6.816795459230438 1.3855677200129615 1.0382825854623041 0.8541613341924247 0.8768852663278748 0.030968112434425602 0.19767384161412466 0.7465144946660024 0.01756694891863117 0.040529888380725465 1.5247707098293942e-07 6.816795459230438 -0.18412125126987944 TKVEATK(ub)NETSAPFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TKVEATKNETSAPFK 15 2 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 12117700.0 2939800.0 5236800.0 3941100.0 True False 4459891.5281684855 4302252.1246948475 3162139.8575545074 1.0 0.9646539826186368 0.7090172120964302 22.08857719120149 -6.932022765841102 0.7299960748331257 1.0036105613921635 0.6537263033715012 0.9969210851217319 0.007193736776971342 0.09160108689680861 0.07263360278441512 0.006634529840071397 0.02287887812509961 1.169438087133703e-07 6.932022765841102 -0.34988425802066236 TLADLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLADLIR 7 0 Q16878 Q16878 CDO1 Cysteine dioxygenase type 1 0 9673400.0 2046300.0 3854200.0 3772900.0 False True 2682719.1163973887 3279168.3835539296 3382516.500212338 1.0 1.2223301215214473 1.260853765695271 21.35526458009339 -13.17099449945885 0.25789773767470214 1.4373376303439777e-07 1.2756413182054882 0.9995070125372851 0.00255267209057572 9.42144877551147 0.15719244182563433 4.871862132042445 0.017036429356247353 6.745365709625136e-14 13.17099449945885 1.275641174471725 TLADLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLADLIR 7 0 Q16878 Q16878 CDO1 Cysteine dioxygenase type 1 0 7637900.0 3506300.0 2339900.0 1791700.0 False True 3394994.4257515874 3274234.272417304 1322400.020152152 1.0 0.9644299406154255 0.38951463664315084 21.694977775032136 -6.919540351061922 0.8281339013063523 1.0128967263839095 0.2977791444127743 0.9940521232772714 0.02157722799629664 0.09844315554882535 0.107023192858351 0.01854582863247549 0.05531137396805894 1.2035375618107535e-07 6.919540351061922 -0.7151175819711352 down TLADLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLADLIR 7 0 Q16878 Q16878 CDO1 Cysteine dioxygenase type 1 0 31666100.0 9010800.0 8341300.0 14314000.0 False True 11664658.229422497 7877099.322408001 11708998.874042802 1.0 0.6752961953517936 1.003801281078983 23.475640701671615 -10.985428893229162 10.374002619116347 1.1132876157298555 0.839548738183079 0.24132258559016784 0.13411163965680978 0.07271145357449181 0.00010212894986786478 0.026869414327013293 0.04328434557694954 1.034120403025467e-11 10.985428893229162 -0.2737388775467765 TLAEHQQLIPLVEK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLAEHQQLIPLVEKAK 16 1 Q9Y5K5-3;Q9Y5K5;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 141170000.0 41389000.0 23183000.0 76598000.0 True False 54261379.811646216 19724186.766626224 68672373.73989886 1.0 0.3635032289096487 1.2655847303971357 25.693422398563882 -6.717115496363003 1.7695649955361645 0.6115742874503943 1.2639669630196155 0.49889992252806126 0.26793980824625435 0.3609674403219123 2.207384068800103 0.12029679594250027 0.30303411768287697 1.9181585573566096e-07 6.717115496363003 0.6523926755692212 TLAEHQQLIPLVEK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLAEHQQLIPLVEKAK 16 1 Q9Y5K5-3;Q9Y5K5;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 264792000.0 90164000.0 105571000.0 69057000.0 True False 87301793.17327838 147726050.8454919 50968900.03440712 1.0 1.6921307739038327 0.5838242054575329 26.379507951234952 -6.737868985523892 1.6947613841077638 1.4128328233617746 0.5835038043927513 0.5952381738113315 0.29082093498455763 0.3216783639356623 1.8133506823836114 0.13580670764183547 0.33400636436988934 1.828651785946346e-07 6.737868985523892 -0.8293290189690233 TLAEHQQLIPLVEK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLAEHQQLIPLVEKAK 16 1 Q9Y5K5-3;Q9Y5K5;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 551008000.0 139385000.0 251200000.0 160423000.0 True False 211457235.4084509 206371397.36544204 128715323.73410127 1.0 0.9759486213220131 0.6087061692898551 27.655790684844202 -6.920211239771573 0.8231756720173876 1.0080415948517898 0.5491997182528073 0.9942389896420601 0.01359074774797198 0.09804772972113396 0.10497716181989397 0.01172289296699506 0.03518594284265723 1.2016797983374313e-07 6.920211239771573 -0.45884187659898246 TLAEHQQLIPLVEK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLAEHQQLIPLVEKAK 16 1 Q9Y5K5-3;Q9Y5K5;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 207633000.0 41389000.0 95916000.0 70328000.0 True False 56691631.795668736 91678113.96820363 53717974.85062544 1.0 1.6171366225377883 0.947546809804997 25.756632460086774 -6.664438893952046 1.957208688849435 1.3957795655061631 0.9503130996261763 0.25466414054070863 0.2624858140227988 0.4739737766236247 3.494812164742746 0.10818032010721104 0.2911300881567332 2.1655145498313078e-07 6.664438893952046 -0.44546646587998684 TLAEHQQLIPLVEK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLAEHQQLIPLVEKAK 16 1 Q9Y5K5-3;Q9Y5K5;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 238797000.0 90164000.0 98087000.0 50546000.0 True False 74975360.94245861 97558585.86225499 61114934.9017017 1.0 1.3012086188838536 0.8151335870007431 26.15991322666923 -6.739060508263142 1.6898661900824765 1.1794061492693677 0.8148900080815762 0.6008753609430382 0.12655798339066043 0.31949717791438115 1.7910345812853607 0.05925292976162907 0.14556675177841982 1.8236416049777996e-07 6.739060508263142 -0.3645161411877915 TLAEHQQLIPLVEK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLAEHQQLIPLVEKAK 16 1 Q9Y5K5-3;Q9Y5K5;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 351230000.0 139385000.0 185810000.0 26035000.0 True False 180436630.18911245 175469510.1598831 21296897.14165885 1.0 0.9724716648497403 0.11802978762869794 27.42691700693665 -6.9157574289068116 0.87184178864393 1.0232627899654723 6.740621897189645e-18 0.9922706690875759 0.035995744640215016 0.10139166905938123 0.12588941990641314 0.030030395585883635 0.08467852799847929 1.214066766685361e-07 6.9157574289068116 -1.0232627899654723 down TLAEIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLAEIAK 7 0 Q15233;Q15233-2;C9JYS8;C9IZL7;C9J4X2;Q8WXF1;Q8WXF1-2;X6RDA4 Q15233;Q8WXF1 NONO;PSPC1 Non-POU domain-containing octamer-binding protein;Paraspeckle component 1 0 6863500.0 1103000.0 3601700.0 2158800.0 False True 1446043.6814671957 3064340.3993166387 1935428.0846718415 1.0 2.1191202164843834 1.3384298894125404 20.463679702584344 -10.191128390601229 4.8775272238573555 0.9999173390861589 1.7287750529502326 0.5374435620614231 0.31871549141486727 0.0002865192732875606 4.751493609179495e-05 0.3086296724851102 0.10286498253480332 6.439788577185087e-11 10.191128390601229 0.7288577138640737 TLAEIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLAEIAK 7 0 Q15233;Q15233-2;C9JYS8;C9IZL7;C9J4X2;Q8WXF1;Q8WXF1-2;X6RDA4 Q15233;Q8WXF1 NONO;PSPC1 Non-POU domain-containing octamer-binding protein;Paraspeckle component 1 0 5589400.0 3119700.0 1473400.0 996300.0 False True 3020666.831137442 2061736.3036794972 735339.1416406697 1.0 0.6825434312804182 0.24343603010457637 21.5264356380069 -7.249533449877972 0.39067388713797274 1.0332426187140755 4.5722408358868605e-22 0.9996358215583978 0.005919572507098916 0.09551611398744944 0.027593072304824103 0.010273379062289426 0.04768560742307977 5.629457569721076e-08 7.249533449877972 -1.0332426187140755 down TLAEIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLAEIAK 7 0 Q15233;Q15233-2;C9JYS8;C9IZL7;C9J4X2;Q8WXF1;Q8WXF1-2;X6RDA4 Q15233;Q8WXF1 NONO;PSPC1 Non-POU domain-containing octamer-binding protein;Paraspeckle component 1 0 33683400.0 4802700.0 25374000.0 3506700.0 False True 7286047.024401247 20845811.452033147 2813599.2079587905 1.0 2.8610591425253964 0.3861626473910943 22.796704875638955 -6.705491055537956 1.8110870243648818 2.1493655062515917 0.3926718664239215 0.4437346226821759 0.7848166702982038 0.38422154305524997 2.4536929207088023 0.3452079615598029 0.8818817489502455 1.9701937836983499e-07 6.705491055537956 -1.7566936398276702 TLAEIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLAEIAK 7 0 Q15233;Q15233-2;C9JYS8;C9IZL7;C9J4X2;Q8WXF1;Q8WXF1-2;X6RDA4 Q15233;Q8WXF1 NONO;PSPC1 Non-POU domain-containing octamer-binding protein;Paraspeckle component 1 0 6109460.0 3119700.0 2145800.0 843960.0 False True 2594168.776143338 2134240.1494920487 1020428.1339698512 1.0 0.8227067448807053 0.3933545663466379 21.306840913441178 -6.956140462886777 0.4867965368409295 1.009674647778783 0.188279017399774 0.9995991656815836 0.005099070943840369 0.0811098690553782 0.026453882892157884 0.006139638731339418 0.035412292881020616 1.1062659290112221e-07 6.956140462886777 -0.821395630379009 down TLAEIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLAEIAK 7 0 Q15233;Q15233-2;C9JYS8;C9IZL7;C9J4X2;Q8WXF1;Q8WXF1-2;X6RDA4 Q15233;Q8WXF1 NONO;PSPC1 Non-POU domain-containing octamer-binding protein;Paraspeckle component 1 0 12960100.0 4802700.0 3664300.0 4493100.0 False True 6217189.825370383 3460378.4838214256 3675401.903099189 1.0 0.5565824079716396 0.5911677150504617 22.567831197731405 -9.89626347385262 5.651901662096739 1.0000002462217885 0.5738750623055091 0.9950837907769722 0.014119392493430881 4.380489340034386e-08 8.578366830729222e-09 0.013671050735955452 0.004557014331650243 1.2698035185593823e-10 9.89626347385262 -0.4261251839162794 TLAEIAK(ub)VELDNMPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLAEIAKVELDNMPLR 16 1 Q15233;Q15233-2;C9JYS8;C9IZL7;C9J4X2 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 4526200.0 1134100.0 2049300.0 1342800.0 True False 1486816.0826400234 1743552.4281088351 1203859.9370471342 1.0 1.1726752545028603 0.8096898810171154 20.503794768111003 -6.777337087344695 1.546104188527172 1.098112277116799 0.8070444121944903 0.7578841607235202 0.07294505848433039 0.254744037578825 1.202575068542972 0.03716588992034188 0.08789827950418966 1.6697940633121322e-07 6.777337087344695 -0.29106786492230874 TLAEIAK(ub)VELDNMPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLAEIAKVELDNMPLR 16 1 Q15233;Q15233-2;C9JYS8;C9IZL7;C9J4X2 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 17155700.0 3640400.0 5393400.0 8121900.0 True False 3524837.4946542177 7547012.746209443 5994530.738222789 1.0 2.1410952299659973 1.7006544974950244 21.749125315896396 -10.123010345946517 4.786572633697352 0.9999415982396155 1.920874863738037 0.8535573193643927 0.17980917610782096 125447878.34386435 9.118682607808001 80747.69113413214 0.06155346362151915 7.533376171931607e-11 10.123010345946517 0.9209332654984216 TLAEIAK(ub)VELDNMPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLAEIAKVELDNMPLR 16 1 Q15233;Q15233-2;C9JYS8;C9IZL7;C9J4X2 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 41891600.0 6969600.0 10630000.0 24292000.0 True False 10573392.746010974 8732993.44743092 19490675.55243815 1.0 0.8259405147629286 1.8433700535517705 23.33393504116543 -6.862841346887182 1.1713935189670117 0.9047628230720286 1.8953575456412477 0.9569959099191001 0.09213924804235335 0.14389786651574218 0.37360930022570765 0.06127784621312257 0.14352026812174096 1.3713826576109733e-07 6.862841346887182 0.9905947225692191 TLAEIAK(ub)VELDNMPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLAEIAKVELDNMPLR 16 1 Q15233;Q15233-2;C9JYS8;C9IZL7;C9J4X2 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 5753600.0 1134100.0 2021800.0 2597700.0 True False 1553407.417900115 1932470.190801474 1984176.7613108524 1.0 1.2440201897669405 1.2773060939756862 20.567004829633895 -12.822718959269409 0.29837464476392545 5.478825030690061e-09 1.285975528279968 0.9995710449744054 0.0025604584054641343 8.323661184917226 0.16938541776186075 5.051155631990899 0.012116282477915283 1.504114994414096e-13 12.822718959269409 1.2859755228011431 TLAEIAK(ub)VELDNMPLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLAEIAKVELDNMPLR 16 1 Q15233;Q15233-2;C9JYS8;C9IZL7;C9J4X2 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 13217600.0 3640400.0 6480800.0 3096400.0 True False 3027153.8970645336 6445886.644061925 3743842.923863989 1.0 2.129355448466818 1.2367534163011789 21.529530591330673 -10.105052092849874 4.197378260969876 0.99988770978109 1.6830544314425302 0.4384511205253254 0.36440325412830454 67468987.78403285 126147656.87790407 104036.27405202392 0.13335794411427232 7.851414526423485e-11 10.105052092849874 0.6831667216614402 TLAEIAK(ub)VELDNMPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TLAEIAKVELDNMPLR 16 1 Q15233;Q15233-2;C9JYS8;C9IZL7;C9J4X2 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 57399700.0 9060500.0 11628200.0 36711000.0 True False 11728995.859155953 10981080.447990682 30029974.686669394 1.0 0.9362336366943612 2.5603193186590847 23.483576171096637 -6.897761595957294 0.9753237293532588 0.9282670514086184 2.723244812302423 0.9854189839123163 0.09068741002554254 0.11307127617944598 0.1868637470208768 0.07002091424195461 0.18021763312906328 1.2654308095112342e-07 6.897761595957294 1.7949777608938045 up TLAESALQLLYTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLAESALQLLYTAK 14 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 5510200.0 1292900.0 2823900.0 1393400.0 False True 1695004.4204614114 2402585.127475986 1249224.334436605 1.0 1.4174506558643416 0.7370035849797626 20.69285760514564 -6.740737522831135 1.6844172212282513 1.2481727157513316 0.7365726891148566 0.6080941138275597 0.17539103715609872 0.3164714147303126 1.7634144254253215 0.082371792533534 0.20193666138241106 1.8166132485407432e-07 6.740737522831135 -0.511600026636475 TLAESALQLLYTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLAESALQLLYTAK 14 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 11235100.0 3854300.0 3555800.0 3825000.0 False True 3731947.356237157 4975649.483252038 2823117.7524596658 1.0 1.3332582183766064 0.7564730911172755 21.83149720464802 -6.750089825895064 1.6500240461995688 1.1959433385577467 0.7553542890671074 0.6491553712309674 0.1400363070581493 0.29988509503625466 1.6065043039416704 0.06704956920568386 0.16273020481874903 1.7779116434006543e-07 6.750089825895064 -0.44058904949063926 TLAESALQLLYTAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLAESALQLLYTAK 14 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 22463200.0 4621300.0 11382000.0 6459900.0 False True 7010849.962284851 9350793.172028093 5183097.933525246 1.0 1.333760274764267 0.7392966560984658 22.74115792968543 -6.754353569908972 1.633642266268469 1.195222661466614 0.7377051158703929 0.6675148526331691 0.14028985032246546 0.29251692616613767 1.5371810119929379 0.06780045094834734 0.16386179149542698 1.7605421617719147e-07 6.754353569908972 -0.45751754559622104 TLAESALQLLYTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLAESALQLLYTAK 14 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 12521400.0 1292900.0 3150300.0 8078200.0 False True 1770920.0693087552 3011109.3293510173 6170295.535751368 1.0 1.7003078690764097 3.484231526135352 20.75606766666853 -6.955058764734909 0.5002405521377058 0.9643479067485045 4.297164320489595 0.9995407727210116 0.022412135909556926 0.0815158627671186 0.028031641879443372 0.026271774612965742 0.14715863031721485 1.1090247420814189e-07 6.955058764734909 3.332816413741091 TLAESALQLLYTAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLAESALQLLYTAK 14 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 7558600.0 3854300.0 1847500.0 1856800.0 False True 3205021.2244412224 1837547.1507999613 2245048.2951268065 1.0 0.5733338477720463 0.7004784486312468 21.611902480082296 -10.603714734256862 9.658333042513988 1.000054021149199 0.6369061482016484 0.9157808450575455 0.051906565942478784 6.038853423344502e-05 2.477749295114358e-06 0.0502657215520184 0.016752772121169785 2.4904926578727057e-11 10.603714734256862 -0.3631478729475507 TLAESALQLLYTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLAESALQLLYTAK 14 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 16014200.0 4621300.0 5302100.0 6090800.0 False True 5982363.9494418 5007033.47407952 4982336.896885559 1.0 0.8369657072680633 0.8328374767888285 22.512284251777878 TLAFAIPMIHAVLQWQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLAFAIPMIHAVLQWQK 17 0 G3V529;Q9GZR7-2;Q9GZR7 G3V529 DDX24 ATP-dependent RNA helicase DDX24 0 20258200.0 5218600.0 7029900.0 8009700.0 False True 7916997.730764016 5775359.4201406045 6426579.284223773 1.0 0.729488578441624 0.8117444898652999 22.916522007192274 -10.252987069457678 7.705970719452722 1.000000401885503 0.770616534153462 0.912040007682773 0.033580835219262646 2.3185697248707085e-07 2.2477471611536405e-08 0.032514560816602325 0.010838167962994973 5.584868226938814e-11 10.252987069457678 -0.2293838677320411 TLAFLIPAVELIVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLAFLIPAVELIVK 14 0 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 15721900.0 5393400.0 7121600.0 3206900.0 False True 8182182.110355771 5850694.838685227 2573054.8093657973 1.0 0.7150531190549158 0.31447048900429786 22.96405421688787 -7.032281919326041 0.3465253796080455 1.042158953924676 8.768963480471699e-14 0.9999309948995793 0.0023358212732491547 0.07284432189116413 0.013982511399333248 0.005699106409320047 0.03270692063044806 9.283635502168368e-08 7.032281919326041 -1.0421589539245883 down TLAFLIPAVELIVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLAFLIPAVELIVK 14 0 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 9616400.0 5393400.0 1438200.0 2784800.0 False True 6981862.619808151 1358162.9057205943 2277994.9744609785 1.0 0.19452730305339552 0.32627324519364054 22.73518053898032 -10.436494317302884 6.469817069842027 1.0001671929869222 0.26040027453334263 0.9767550850601213 0.05378505565430609 0.00012973854368278923 1.1299841229497538e-05 0.05208860352519324 0.01735905206866386 3.660207298690457e-11 10.436494317302884 -0.7397669184535796 TLAFTSVDLTNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLAFTSVDLTNK 12 0 Q9NPJ3-2;Q9NPJ3 Q9NPJ3-2 ACOT13 Acyl-coenzyme A thioesterase 13;Acyl-coenzyme A thioesterase 13, N-terminally processed 0 19175500.0 6364900.0 5610500.0 7200100.0 False True 8344445.53777927 4773435.269557707 6455102.720236117 1.0 0.5720494247276344 0.773580783889211 22.992384759538567 -10.095330620012867 4.906561485664229 1.0000107148027746 0.6728151043088617 0.778482161212877 0.08227483286247089 1.072101196608154e-05 1.9767383219708192e-06 0.07966516294448181 0.026554088122593973 8.02914646028382e-11 10.095330620012867 -0.3271956104939129 TLAFTSVDLTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLAFTSVDLTNK 12 0 Q9NPJ3-2;Q9NPJ3 Q9NPJ3-2 ACOT13 Acyl-coenzyme A thioesterase 13;Acyl-coenzyme A thioesterase 13, N-terminally processed 0 18667400.0 6364900.0 5517700.0 6784800.0 False True 8718175.534954967 5273909.769406125 5182369.97734222 1.0 0.6049327348664547 0.5944328554252939 23.055594821061458 TLAGLPLLVAYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLAGLPLLVAYK 12 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 17005600.0 4068000.0 5307200.0 7630400.0 False True 5333187.394568045 4515386.44730357 6840879.403965181 1.0 0.8466581264147176 1.2826999874282965 22.34656659085046 -6.811683735704205 1.4075070256069389 0.9165943167928781 1.2906207015471212 0.8641551458623188 0.06656606130987555 0.2045194233289788 0.7982374364660383 0.03718421381701976 0.08594843192025207 1.542823567350827e-07 6.811683735704205 0.3740263847542431 TLAGLPLLVAYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLAGLPLLVAYK 12 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 16662300.0 7239200.0 5151500.0 4271600.0 False True 7009395.558537732 7208520.814717606 3152739.8147468483 1.0 1.028408334858108 0.4497876868864508 22.740858610949843 -6.895357450449838 0.9901660350640552 1.0272160289068457 0.3944697894445768 0.9841111453972606 0.03357004371054206 0.11490323540546205 0.19732417066168337 0.02563367801402398 0.06526811882131679 1.2724553427073167e-07 6.895357450449838 -0.6327462394622689 down TLAGLPLLVAYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLAGLPLLVAYK 12 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 16773700.0 4068000.0 4663900.0 8041800.0 False True 5572049.533566416 4457833.476545153 6142492.466069832 1.0 0.8000347896569929 1.1023757827469098 22.409776652373353 -6.728360705486007 1.7292057478915208 0.8794417817373464 1.1021424358619256 0.5516318457592422 0.08407213276546108 0.33932907342749485 1.987022202387062 0.038540547886406706 0.09581381888330973 1.869129080860337e-07 6.728360705486007 0.22270065412457918 TLAGLPLLVAYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLAGLPLLVAYK 12 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 12706400.0 7239200.0 3394100.0 2073100.0 False True 6019715.55093658 3375815.3096238994 2506575.6250686035 1.0 0.5607931605835881 0.4163943634643363 22.52126388638412 -13.999999999999998 0.15549874904703243 3.1437405617227863 0.26714934670140705 0.9995489360503669 0.005270954367419168 11.98266700565879 0.12444735017282492 7.751801166985631 0.13529638176213338 1.0000000000000041e-14 13.999999999999998 -2.8765912150213793 TLAGLVVQLLQFQEDAFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLAGLVVQLLQFQEDAFGK 19 0 Q92922;F8WE13 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 0 921460000.0 333150000.0 362070000.0 226240000.0 False True 505412906.52742726 297455779.6341779 181523564.83548537 1.0 0.5885401338045092 0.3591589421067438 28.912887265378746 -9.518401511014858 0.1506429063418658 1.5976183154041093 3.3665343394000503e-13 0.9997845237181565 0.003891705114398096 0.9638509620566822 0.059737896649225276 0.4311847749608191 0.18618956364409825 3.031087607683584e-10 9.518401511014858 -1.5976183154037726 TLAMDTILANAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLAMDTILANAR 12 0 D6RAY7;D6R9P4;P46926;D6RFF8;P46926-2 D6RAY7 GNPDA1 Glucosamine-6-phosphate isomerase;Glucosamine-6-phosphate isomerase 1 0 3787630.0 971430.0 1105800.0 1710400.0 False True 1273554.137341501 940818.9503746395 1533424.2153153247 1.0 0.7387349487463215 1.2040510649325777 20.280428857569213 -6.754356936874623 1.6338296716024685 0.8471830787053016 1.2052866820283668 0.6674850235934807 0.10981701593432408 0.2924927977202861 1.5374418290621654 0.05306959394748823 0.12824932418279986 1.760528512825738e-07 6.754356936874623 0.3581036033230651 TLAPLLASLLSPGSVLVLSAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLAPLLASLLSPGSVLVLSAR 21 0 P35270 P35270 SPR Sepiapterin reductase 0 681980000.0 274040000.0 229230000.0 178710000.0 False True 415738715.0075827 188322115.51783517 143387890.16862437 1.0 0.4529819059896799 0.34489905556668954 28.631101862001554 -13.99999999999996 0.22797812182380903 4.421165121572745 0.29132698542345087 0.9995071001859834 0.0063663966143507784 13.229110471573904 0.1511967927315804 20.463740809057516 0.05681893079469257 1.000000000000094e-14 13.99999999999996 -4.129838136149294 TLAPLLASLLSPGSVLVLSAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLAPLLASLLSPGSVLVLSAR 21 0 P35270 P35270 SPR Sepiapterin reductase 0 479741000.0 274040000.0 67661000.0 138040000.0 False True 354750182.135986 63895605.871200845 112918136.41000901 1.0 0.18011437086932297 0.31830325140389704 28.402228184094003 -10.33571772481736 6.461108667955146 1.000038328268482 0.24920881186271002 0.9752216454506818 0.05641537423935511 3.114926354568514e-05 3.2024455377967534e-06 0.054626721946480765 0.01820798374159006 4.616175112065762e-11 10.33571772481736 -0.7508295164057719 TLAPTWEELSKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLAPTWEELSKK 12 1 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 9802000.0 3280700.0 3505600.0 3015700.0 False True 4301029.470343991 2982578.144721774 2703664.2926370557 1.0 0.6934568026764139 0.6286086415540928 22.03625058588306 -13.999999999999998 0.21831719549906878 2.8362842687906786 0.5933569096040786 0.9994962626515008 0.0036352424247049165 12.95439068481061 0.1480333428205753 10.246386470617562 0.03629109420952243 1.0000000000000041e-14 13.999999999999998 -2.2429273591866 TLAPTWEELSKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLAPTWEELSKK 12 1 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 6199760.0 2233000.0 961360.0 3005400.0 False True 2162114.637282402 1345236.0614261697 2218195.5799326245 1.0 0.6221853542035216 1.0259380060997652 21.044011587426464 -10.137041591278654 14.399464118405835 0.9999935868674307 0.8240616799059783 0.20202982932546265 0.16483132994847882 0.0 0.0 0.15959724893712893 0.05319908297904296 7.293876553078948e-11 10.137041591278654 -0.17593190696145233 TLAPTWEELSKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLAPTWEELSKK 12 1 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 65208500.0 9643500.0 44091000.0 11474000.0 False True 14629894.534285586 36222616.56544469 9206158.870767137 1.0 2.4759314894961086 0.6292703511424661 23.802416033454744 -6.693859547441494 1.8525020237053904 1.921976082013034 0.6353211087452992 0.3884924251963118 0.6237409543149056 0.408507512468695 2.72088880182984 0.2690469620983932 0.6972791821666645 2.0236735369122847e-07 6.693859547441494 -1.2866549732677348 TLAPTWEELSKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLAPTWEELSKK 12 1 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 13014500.0 3280700.0 6247500.0 3486300.0 False True 4493663.447583902 5971464.792280255 2662907.7426023157 1.0 1.3288633788297874 0.592591718018864 22.09946064740595 -6.7852828995998165 1.5151367780168004 1.1849366555607288 0.5857489076759774 0.785666401893067 0.13942150720939367 0.24246229062189684 1.099613746035582 0.07245096471396809 0.1702257950227529 1.639521440356822e-07 6.7852828995998165 -0.5991877478847514 TLAPTWEELSKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLAPTWEELSKK 12 1 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 33833200.0 9643500.0 7635700.0 16554000.0 False True 12483700.851804039 7210766.582680248 13541341.858383732 1.0 0.577614496556781 1.0847217519175696 23.573542355547193 -6.68568704052567 1.8820297049341654 0.7341179945891088 1.0828680401066515 0.350130302973941 0.1788005083517334 0.4260393555253771 2.922347937136574 0.07610400592131644 0.19924315848039856 2.0621153709431633e-07 6.68568704052567 0.34875004551754274 TLAQLNPESSLFIIASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLAQLNPESSLFIIASK 17 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90 P06744 GPI Glucose-6-phosphate isomerase 0 78746000.0 20373000.0 32421000.0 25952000.0 False True 26709200.292412672 27583913.176068187 23266735.989162315 1.0 1.032749497329727 0.8711131645439694 24.670833444698136 -6.853959999378256 1.2158167065901608 1.017554689904928 0.8641402287080437 0.9458739436859172 0.016231989765070193 0.1531539181445753 0.4336698999366831 0.01043523965425199 0.024217219523053692 1.3997162372692464e-07 6.853959999378256 -0.15341446119688418 TLAQLNPESSLFIIASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLAQLNPESSLFIIASK 17 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90 P06744 GPI Glucose-6-phosphate isomerase 0 146959000.0 58323000.0 38997000.0 49639000.0 False True 56471568.28939612 54568705.46666839 36637056.76192033 1.0 0.9663040556448467 0.6487699540088708 25.751021361617457 -6.927183441149105 0.7695610655883589 1.0053665675338128 0.5880237102655937 0.9959551027840775 0.010063242660746605 0.09412700951409268 0.08504020624844824 0.009018909188402157 0.029188997315148776 1.1825419576763373e-07 6.927183441149105 -0.41734285726821907 TLAQLNPESSLFIIASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLAQLNPESSLFIIASK 17 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90 P06744 GPI Glucose-6-phosphate isomerase 0 314986000.0 56398000.0 186130000.0 72458000.0 False True 85559889.24608685 152913647.25967225 58136644.54053039 1.0 1.7872118419866454 0.6794848036013478 26.350431279203686 -6.7158262911774145 1.7741445163856924 1.4810440136679603 0.6815791563832553 0.4928513497478637 0.33144164349367966 0.3634832738813754 2.233544793705002 0.14846380841842907 0.3745683727167315 1.923861079733008e-07 6.7158262911774145 -0.7994648572847051 TLAQLNPESSLFIIASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLAQLNPESSLFIIASK 17 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90 P06744 GPI Glucose-6-phosphate isomerase 0 98417000.0 20373000.0 21534000.0 56510000.0 False True 27905448.659623545 20582556.676584672 43163501.859982476 1.0 0.7375820015524646 1.5467768458579145 24.734043506221028 -6.81938471865205 1.3744400209436292 0.8584655864929954 1.5642238781157987 0.882977468467729 0.11531122056899454 0.19428550100809353 0.72132983609749 0.06592949788485479 0.1519893806508838 1.5157070873437397e-07 6.81938471865205 0.7057582916228032 TLAQLNPESSLFIIASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLAQLNPESSLFIIASK 17 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90 P06744 GPI Glucose-6-phosphate isomerase 0 116008000.0 58323000.0 29430000.0 28255000.0 False True 48498158.64698784 29271454.7486024 34162989.8636407 1.0 0.603558064166224 0.7044182875541507 25.531426637051734 -9.967422375275058 6.834269631847711 1.000000030351281 0.6539881758601892 0.9400913802470003 0.041176013773929473 1.9072922570833787e-08 2.868612972128894e-09 0.03986850746691967 0.013289501300802248 1.0778978972900915e-10 9.967422375275058 -0.34601185449109184 TLAQLNPESSLFIIASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLAQLNPESSLFIIASK 17 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90 P06744 GPI Glucose-6-phosphate isomerase 0 177683000.0 56398000.0 66997000.0 54288000.0 False True 73008322.77078284 63268558.05490385 44408141.04191955 1.0 0.8665937752541174 0.6082613509879344 26.121557601296136 -6.9606717389945905 0.42586289466476634 1.01072316866388 0.45429270008792416 0.9997943013715441 0.002332245805976824 0.07946205753665324 0.02025127778397738 0.0033561502078848764 0.021470995300745498 1.094783544557153e-07 6.9606717389945905 -0.5564304685759558 TLATDILMGVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLATDILMGVLK 12 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 1676830.0 700630.0 976200.0 0.0 False True 959671.8448138228 933068.2561382919 0.0 1.0 0.9722784524529924 0.0 19.872181641943826 -7.045828087973781 1.0565871217629812 1.0138379942795623 3.7209735479206687e-19 0.9876008862176209 0.0517792741354985 0.08554653787344835 0.18414599973554466 0.041114116868153534 0.07376358339966496 8.998537109945201e-08 7.045828087973781 -1.0138379942795623 down TLATWATK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLATWATK 8 0 Q14974;Q14974-2;J3KTM9;J3KS06 Q14974 KPNB1 Importin subunit beta-1 0 10708600.0 2120000.0 6882300.0 1706300.0 False True 3216194.9927604515 5654099.793344673 1369049.0571021428 1.0 1.7580090156448425 0.42567352420603444 21.616923446786444 -6.752370894181385 1.6410795450887896 1.444435371052266 0.42253477077899815 0.6591415484576332 0.31856379910210236 0.29590909819558336 1.568649608421815 0.15330053155442527 0.3712492119850782 1.7685979033080632e-07 6.752370894181385 -1.0219006002732678 TLAVSGLGVVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLAVSGLGVVGR 12 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 0 9886700.0 3475300.0 3624900.0 2786500.0 False True 4760212.326451169 3464739.932058693 2128386.0897689066 1.0 0.7278540734004871 0.4471199904134654 22.18259449485033 -6.97073580608548 0.23996265336818298 1.1008503617757248 0.06600427594348215 0.9999875656382504 0.0007959266571986037 0.07606465237579098 0.008171114521101641 0.0067123743412263815 0.027370508700472387 1.0697054141249421e-07 6.97073580608548 -1.0348460858322426 down TLAVSGLGVVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLAVSGLGVVGR 12 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 0 4898800.0 1209100.0 2075300.0 1614400.0 False True 1005420.2222120423 2064119.9469852012 1951963.5758577785 1.0 2.0529922726677365 1.9414405367371963 19.93936718096724 -10.163379260303618 5.575632037193568 0.9999784177083707 1.9972164047025662 0.9907022416720774 0.04554080549227214 1.221820829179186e-05 1.8332810437795056e-06 0.044095645925314675 0.01469823177031886 6.864686993991367e-11 10.163379260303618 0.9972379869941955 TLAYLLPAIVHINHQPYLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLAYLLPAIVHINHQPYLER 20 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 100846720.0 49395620.0 42624700.0 8826400.0 False True 64758136.16786454 36265260.90977928 7913128.796807272 1.0 0.5600108813473771 0.12219512890696921 25.94855812761492 -7.78098494453136 0.43259827082964053 1.0379905276003416 2.9237718617182127e-21 0.9972843374148619 0.018675003365248955 0.11354694159316361 0.07972057767699625 0.03206865081241699 0.07776856019840658 1.6558273642100257e-08 7.78098494453136 -1.0379905276003416 down TLAYLLPAIVHINHQPYLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLAYLLPAIVHINHQPYLER 20 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 716765000.0 397450100.0 164463600.0 154851300.0 False True 384833264.12868553 230134773.14634386 114291099.09057707 1.0 0.5980116445167495 0.29698861752335143 28.519658266937 -7.9326951020129055 0.2390349690725181 1.1841874626549647 6.286828416240428e-13 0.9997069075643964 0.004930337007462723 0.1095144343871012 0.040537847063159584 0.06289362981518304 0.0940392504896637 1.1676290675218238e-08 7.9326951020129055 -1.184187462654336 down TLAYLLPAIVHINHQPYLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLAYLLPAIVHINHQPYLER 20 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 474054700.0 127204000.0 191490700.0 155360000.0 False True 192977767.8580666 157317688.4613322 124653027.90329288 1.0 0.8152114629962864 0.6459450188841134 27.523859409450232 -6.972174324616807 0.19953949731323573 1.1013520713743417 0.3551333486267195 0.9999947427590881 0.0003314722924977556 0.07560336901748191 0.006439200823585387 0.0055164140451169855 0.017990693029035887 1.0661680783787629e-07 6.972174324616807 -0.7462187227476221 TLAYLLPAIVHINHQPYLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLAYLLPAIVHINHQPYLER 20 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 299303140.0 49395620.0 76285420.0 173622100.0 False True 67658515.58043846 72914877.9022507 132616135.83939229 1.0 1.07768958979839 1.9600804821342321 26.01176818913781 -6.924201877559308 0.7929321855926176 0.9833182180645842 2.1171036581012004 0.9952709444671669 0.029943796362453253 0.09576194548695631 0.09325943878657336 0.02639152633159244 0.08253212231431163 1.1906883994639643e-07 6.924201877559308 1.133785440036616 TLAYLLPAIVHINHQPYLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLAYLLPAIVHINHQPYLER 20 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 625956800.0 397450100.0 79851000.0 148655700.0 False True 330497368.1748399 79420826.81381752 179738919.5637023 1.0 0.24030698717032525 0.5438437242520391 28.300063542371277 -10.475814101455425 6.1460576371598625 1.0003648992782193 0.39207535571588903 0.8424774989303592 0.12391835400658888 0.0006199490348577267 5.287443926135145e-05 0.12005222698159332 0.03999447677974612 3.3433812190383074e-11 10.475814101455425 -0.6082895435623302 TLAYLLPAIVHINHQPYLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLAYLLPAIVHINHQPYLER 20 0 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 582233500.0 127204000.0 186989500.0 268040000.0 False True 164668085.56570563 176583369.9480192 219259470.32265177 1.0 1.0723594031070407 1.3315237714059849 27.29498573154268 -6.947415558041 0.5865387209877291 0.9969720697552108 1.4198744155080616 0.9989824836573107 0.004539984947153246 0.08454057994422694 0.04038866138653206 0.0047237262748968676 0.021689332818833264 1.1287153777378942e-07 6.947415558041 0.4229023457528508 TLCAK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLCAKLR 7 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 13180700.0 3187500.0 5704100.0 4289100.0 True False 4178843.367793913 4853070.514407652 3845305.075952385 1.0 1.1613430050549314 0.9201840647074531 21.994672253626543 -6.7263995661864975 1.736049736058583 1.0974848457436863 0.920412580609683 0.5425275332616449 0.06784672865137488 0.3430832681246535 2.0239378185763583 0.03098951793360865 0.07722287281371215 1.8775885744275658e-07 6.7263995661864975 -0.17707226513400331 TLCAK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLCAKLR 7 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 8495700.0 3231100.0 3318200.0 1946400.0 True False 3128530.499114721 4643174.564184409 1436579.449251633 1.0 1.4841391399247301 0.45918665317731155 21.57705373783548 -6.778256736671065 1.5425585302215006 1.274758837356912 0.45149582300251256 0.7611746499811223 0.2045924083214901 0.25331133250419474 1.1904113537099006 0.10447373727478987 0.24688651799262787 1.6662618972378925e-07 6.778256736671065 -0.8232630143543995 down TLCAK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLCAKLR 7 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 26824700.0 7024300.0 4892400.0 14908000.0 True False 10656376.645116637 4019312.995504329 11961427.265591478 1.0 0.3771744495673592 1.1224666379517367 23.34521364407935 -6.684989234017623 1.8842487906349183 0.6077056355832288 1.1197435792055153 0.34704520995481103 0.26368592553546827 0.4275428166155196 2.938938046738359 0.11211934646593819 0.29382106826060256 2.0654313563735046e-07 6.684989234017623 0.5120379436222865 TLCAK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLCAKLR 7 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 12207400.0 3187500.0 4139300.0 4880600.0 True False 4366004.88894861 3956412.039165363 3727902.7991121938 1.0 0.9061858930071235 0.853847600708922 22.057882315149435 -13.999999999971601 0.06898259943725202 1.5475746316297212 0.6598573993443457 0.9999278167257982 0.0005136573908906584 12.370699273557808 0.07053887264208852 1.0970450835476482 0.1789719146407834 1.0000000000653903e-14 13.999999999971601 -0.8877172322853755 TLCAK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLCAKLR 7 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 11212600.0 3231100.0 2072600.0 5908900.0 True False 2686802.8120001107 2061434.4924211132 7144423.670333263 1.0 0.767244430150994 2.6590800182372925 21.357459013269757 -6.8761092206742385 1.1013263463269154 0.8620024379222969 2.783509001629676 0.9704065455171923 0.14490487408362318 0.13112953359228055 0.293620920865512 0.10168729979073442 0.24364031786733248 1.330119864204628e-07 6.8761092206742385 1.921506563707379 up TLCAK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLCAKLR 7 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 21966900.0 7024300.0 4825600.0 10117000.0 True False 9093094.819653358 4557051.117956687 8275809.809186196 1.0 0.501155130166168 0.9101202586493738 23.1163399661718 -10.00365263399063 7.073874030013219 1.0000000263539945 0.7056376944077716 0.40855188758185257 0.1669593145626037 6.959142332381919e-08 9.534922971915603e-09 0.16165767565208364 0.05388588706626402 9.916247687362026e-11 10.00365263399063 -0.29436233194622297 TLCMQHGPLITFHLNLPHGNALVR ddPTM_RPMI8226_Bortezomib_8h_R1 2 TLCMQHGPLITFHLNLPHGNALVR 24 0 Q8NDV7-2;Q8NDV7-6;Q8NDV7-5;Q8NDV7;H3BRT3;H7C269 Q8NDV7-2 TNRC6A Trinucleotide repeat-containing gene 6A protein 0 130607000.0 29554000.0 43617000.0 57436000.0 False True 44835578.686812535 35833205.56882357 46083749.424906954 1.0 0.7992136294063975 1.0278388452798435 25.418140682740646 -6.67476586795664 1.920591960688747 0.8723660123689876 1.0269339612976536 0.30025971126991735 0.08519749176920223 0.45027662074062713 3.2065095763523863 0.03565621140605239 0.09467245671887846 2.1146287478855412e-07 6.67476586795664 0.154567948928666 TLCMQHGPLITFHLNLPHGNALVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLCMQHGPLITFHLNLPHGNALVR 24 0 Q8NDV7-2;Q8NDV7-6;Q8NDV7-5;Q8NDV7;H3BRT3;H7C269 Q8NDV7-2 TNRC6A Trinucleotide repeat-containing gene 6A protein 0 66693000.0 13267000.0 27884000.0 25542000.0 False True 17174393.031667363 26332230.88799404 20893618.08305167 1.0 1.5332262886636405 1.2165564188805122 24.033755777189292 -10.325587444035422 5.1793497784830285 0.9998795277831729 1.374891353772116 0.6514082224902851 0.1292799329805143 0.00017990108029677986 2.342537564136971e-05 0.1252147205531362 0.04172491895267538 4.725116883517136e-11 10.325587444035422 0.375011825988943 TLCPLCFSILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLCPLCFSILK 11 0 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 0 16379600.0 4707400.0 7236700.0 4435500.0 False True 6171446.986526443 6157012.568435667 3976557.00832034 1.0 0.9976610966403359 0.6443475925503361 22.55717735943423 -6.908352093451125 0.9068857941484715 1.0115175503186917 0.6002616349288373 0.9902846441827424 0.01647121061116517 0.10551778388356549 0.14475371810467969 0.013376275169950018 0.03651618725745775 1.234945825867587e-07 6.908352093451125 -0.4112559153898544 TLCPLCFSILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLCPLCFSILK 11 0 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 0 15977500.0 4707400.0 6058700.0 5211400.0 False True 6447852.992701697 5791006.600558357 3980574.652152047 1.0 0.8981294404685061 0.6173488534334833 22.620387420957123 -6.9533386907547925 0.5209029482883005 1.0047381219737517 0.4981905610125373 0.9994379130321847 0.0038362065597332766 0.082172157865504 0.03062359187867195 0.004339711202307471 0.023194713191934304 1.1134258738464862e-07 6.9533386907547925 -0.5065475609612144 TLDECLTHLLEWGK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLDECLTHLLEWGKQR 16 1 Q5VWM4;Q5VXH5 Q5VWM4 PRAMEF8;PRAMEF7 PRAME family member 8;PRAME family member 7 1 16988300.0 2230000.0 3942300.0 10816000.0 True False 2886778.959871726 3722907.5394397825 8847598.981531855 1.0 1.2896406656660715 3.0648688744513355 21.461029214236 -6.9353869971198225 0.7011736712307478 0.9776250889830547 3.484913205370101 0.9974949667782826 0.04568645535424766 0.08993566677561178 0.06467589614131757 0.043048152938295337 0.15614530994563455 1.1604141151686649e-07 6.9353869971198225 2.5072881163870466 up TLDELGIHLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLDELGIHLTK 11 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 12969600.0 2708900.0 5810700.0 4450000.0 False True 3551394.1330249174 4943766.2099312 3989556.687414164 1.0 1.3920635178051395 1.123377619598656 21.75995404858112 -10.232503591730758 4.2887423257093715 0.9998710263068787 1.2577205687086557 0.5509099311044763 0.10969055865378087 0.00013818869397348444 2.4729347087815764e-05 0.1062615130137463 0.035402475569604984 5.854588943999412e-11 10.232503591730758 0.25784954240177693 TLDELGIHLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLDELGIHLTK 11 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 13181600.0 6008400.0 3384900.0 3788300.0 False True 5817666.630831881 4736508.2220203085 2796030.583436068 1.0 0.8141594427082227 0.4806103135263798 22.47200919752154 -6.96210526037504 0.4046720369745707 1.01741698730866 0.2650811544950376 0.9998404848779987 0.002713902199440344 0.078957489462708 0.01841439019745465 0.0042911644552555035 0.027898835194802896 1.0911758350502483e-07 6.96210526037504 -0.7523358328136225 down TLDELGIHLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLDELGIHLTK 11 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 12073800.0 2708900.0 4289600.0 5075300.0 False True 3710453.5352699244 4100071.2881897325 3876618.669084568 1.0 1.1050054256753992 1.0447829712015395 21.82316411010401 -10.207843736322872 4.290672355691279 0.9999701072972116 1.0748941984415288 0.6734310072333594 0.0245857140967809 7.033133505797312e-06 1.2984630812873847e-06 0.02381451449862795 0.007935005102856602 6.196639965284886e-11 10.207843736322872 0.0749240911443172 TLDELGIHLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLDELGIHLTK 11 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 8741400.0 6008400.0 1664000.0 1069000.0 False True 4996250.817251545 1655035.701721861 1292522.957502456 1.0 0.33125552784643864 0.25869857314598893 22.252414472955817 -13.999999999999998 0.3136618813106134 7.604684736915399 0.24325276104513546 0.9996800148821352 0.005968700431780395 17.5345980653801 0.17833930573542126 75.73714714043494 0.024772184276655427 1.0000000000000041e-14 13.999999999999998 -7.361431975870263 TLDELGIHLTK(ub)EELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLDELGIHLTKEELK 15 1 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 1 36192100.0 14764800.0 20058100.0 1369200.0 True False 19356795.78252658 17065509.665861446 1227528.3182938143 1.0 0.8816288531217816 0.06341588412075447 24.20633682078858 -7.073562755300071 0.8462890390250389 1.0012932342877374 4.341890422336449e-26 0.9949166736385673 0.029689906576987404 0.07928456830862757 0.09958704209876575 0.026311734238322775 0.059591115213389584 8.441842489622294e-08 7.073562755300071 -1.0012932342877374 down TLDELGIHLTK(ub)EELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLDELGIHLTKEELK 15 1 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 1 42155200.0 30484100.0 9572900.0 2098200.0 True False 29516398.931652736 13395408.892014004 1548618.4753492454 1.0 0.45382937542726676 0.05246637568949988 24.815013384242995 -8.168682947832409 0.4639591777510537 1.0463159777876634 5.655054420252395e-22 0.9950947702114183 0.027197730866342303 0.10829574843525835 0.12644954524757063 0.05458706111949754 0.07781509850548862 6.7813639336342695e-09 8.168682947832409 -1.0463159777876634 TLDELGIHLTK(ub)EELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLDELGIHLTKEELK 15 1 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 1 88468000.0 54705000.0 10873000.0 22890000.0 True False 82991484.47120784 8932628.198863255 18365781.46695659 1.0 0.10763306929353991 0.22129717987305328 26.306459977280515 -10.590176138979588 6.410749427375395 1.001970999435051 0.16446512458330087 0.9863103479051886 0.046403178831181835 0.0013091798108718434 8.36926730220097e-05 0.04499744034265372 0.014976561568687652 2.5693535059033262e-11 10.590176138979588 -0.8375058748517501 TLDELGIHLTK(ub)EELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLDELGIHLTKEELK 15 1 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 1 45346800.0 14764800.0 22865500.0 7716500.0 True False 20223745.563717127 21855226.603902988 5894021.6263060365 1.0 1.0806715568610028 0.2914406536482708 24.26954688231147 -6.881704566311906 1.070281104597737 1.051216209308668 0.23365515453390678 0.9750331394487289 0.056024543965285584 0.12612933620693578 0.26327132135990694 0.040260201994619146 0.09779225667559435 1.313092841387843e-07 6.881704566311906 -0.8175610547747614 down TLDELGIHLTK(ub)EELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLDELGIHLTKEELK 15 1 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 1 58593300.0 30484100.0 28109200.0 0.0 True False 25348879.82460854 27957770.16036067 0.0 1.0 1.102919353983423 0.0 24.59541865967727 -6.958687938516045 1.188789815972664 1.0602558881691255 6.585941003834195e-20 0.9745540815104339 0.07935059898328832 0.104190840057805 0.2919649520652189 0.05565419672301808 0.10502509336294324 1.099795811796061e-07 6.958687938516045 -1.0602558881691255 down TLDELGIHLTK(ub)EELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLDELGIHLTKEELK 15 1 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 1 94430100.0 54705000.0 25125100.0 14600000.0 True False 70816700.89676361 23726866.09826206 11942949.808650618 1.0 0.33504619387524165 0.16864595014191663 26.077586299372964 -13.99999999999955 0.19454368657470716 4.622297483802916 0.05457666584940017 0.9994875458729653 0.008130600971138194 12.428266045403772 0.139871855778354 17.09317372811439 0.11043336336526098 1.0000000000010348e-14 13.99999999999955 -4.567720817953515 TLDGIFSEQVAMGYSHSLVIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLDGIFSEQVAMGYSHSLVIAR 22 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 9492900.0 2997900.0 3074800.0 3420200.0 False True 2902733.3054674976 4302583.674870175 2524347.016199357 1.0 1.482252491734588 0.869644831457501 21.468980596833294 -6.696758032372558 1.842055198551708 1.300393502085975 0.8715487220799597 0.40242642490514946 0.2036862242767971 0.4022777239301286 2.651328762505578 0.08828465635033463 0.22798961110334937 2.010212492669206e-07 6.696758032372558 -0.4288447800060152 TLDGIFSEQVAMGYSHSLVIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLDGIFSEQVAMGYSHSLVIAR 22 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 8749200.0 2997900.0 2313300.0 3438000.0 False True 2492886.679488453 2300837.7937459038 4156869.9044840387 1.0 0.9229612451609881 1.667492525306862 21.24938587226757 -6.881370696464535 1.0721714293922717 0.9513353798257409 1.721653886635851 0.9747724051936516 0.05309751836130063 0.12642073075976504 0.26503296394950826 0.03810197377959311 0.09246607342014151 1.3141026876599538e-07 6.881370696464535 0.7703185068101102 TLDLPIYVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLDLPIYVTR 10 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 6162900.0 1481600.0 1999500.0 2681800.0 False True 1942391.9478348119 1701182.3939899546 2404313.0616420894 1.0 0.8758182898597093 1.2378104554655829 20.889402915365835 -6.814080378802465 1.3971339519920793 0.9326412238209435 1.2447637071075148 0.8702683071412463 0.05409585191976182 0.20127922898534106 0.773517983249891 0.030437251749695856 0.07029259944892545 1.5343329836550474e-07 6.814080378802465 0.31212248328657133 TLDTPFFSTGK(ub)LILGPQEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLDTPFFSTGKLILGPQEEK 20 1 Q03188 Q03188 CENPC Centromere protein C 1 3298470.0 807770.0 1056700.0 1434000.0 True False 1058994.2924558073 899044.4789843395 1285623.4358993054 1.0 0.8489606463312052 1.2140041217011144 20.014263383141778 -6.7943648001293635 1.4790769298377349 0.9160604746849244 1.2183543777385708 0.8150885511148587 0.06440116562686611 0.22890710628831476 0.9891678449572876 0.03426583928205405 0.07996931284187966 1.6055920158800063e-07 6.7943648001293635 0.30229390305364645 TLEEDEEELFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLEEDEEELFK 11 0 P43487-2;P43487;F6WQW2;C9JJ34;C9JDM3 P43487-2 RANBP1 Ran-specific GTPase-activating protein 0 15645600.0 4702900.0 2930800.0 8011900.0 False True 4553609.013737305 4101083.723920091 5913343.03815205 1.0 0.900622717397994 1.29860579165069 22.11857899207713 -6.840587501194815 1.2796882305533002 0.947137750017166 1.3118468497903053 0.925457281666334 0.04617558899517432 0.168112437083638 0.534525312211346 0.028291617998176047 0.06518810190229103 1.4434857430032867e-07 6.840587501194815 0.36470909977313926 TLEFAGQDLSAYLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLEFAGQDLSAYLLK 15 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 9768900.0 3414100.0 4253100.0 2101700.0 False True 4475918.162191436 3618554.058453949 1884236.244929966 1.0 0.8084495576841119 0.42097200544154567 22.093752227604536 -6.959822033274884 0.4379347957868881 1.014156677478157 0.20020938418346107 0.9997635412196674 0.003703687925006685 0.07976475672667958 0.02136668358112101 0.005095864498443631 0.032117785204137585 1.0969276069213838e-07 6.959822033274884 -0.8139472932946958 down TLEFAGQDLSAYLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLEFAGQDLSAYLLK 15 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 55781700.0 29286000.0 9821700.0 16674000.0 False True 28356331.960345946 13743556.029488858 12306579.19072222 1.0 0.48467326622879564 0.43399757091051067 24.757167588718833 -13.999999999999998 0.32791424809654257 6.539722535101595 0.4248022967034594 0.9997104959860397 0.004350855080381021 18.648698367518694 0.1830056816307251 71.17157405523281 0.016366814124056755 1.0000000000000041e-14 13.999999999999998 -6.114920238398136 TLEFAGQDLSAYLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLEFAGQDLSAYLLK 15 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 107692000.0 20637000.0 59338000.0 27717000.0 False True 31307837.76679129 48748670.29008986 22238722.80120733 1.0 1.5570756004682742 0.7103244550729175 24.90002053835899 -6.729261368025643 1.7258554107889739 1.3355326431737102 0.7108972666680841 0.5557768401007689 0.23419727633801532 0.3376715998783294 1.9700659309373332 0.10754889037265593 0.2671056491974283 1.8652568001772053e-07 6.729261368025643 -0.6246353765056262 TLEFAGQDLSAYLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLEFAGQDLSAYLLK 15 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 19572800.0 3414100.0 4086700.0 12072000.0 False True 4676385.032583359 3906136.081090309 9220842.230644269 1.0 0.8352896636769143 1.9717885003901041 22.156962289127428 -6.870104582138022 1.1334881841275137 0.9067786478099316 2.038495413038974 0.9647902346275847 0.09409471947248932 0.13675744842229443 0.32832329472064353 0.06441874572122624 0.1525480012533154 1.3486380789313745e-07 6.870104582138022 1.1317167652290423 TLEFAGQDLSAYLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLEFAGQDLSAYLLK 15 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 53782000.0 29286000.0 15158000.0 9338000.0 False True 24352606.589779116 15076340.845372582 11290532.62596625 1.0 0.6190853036528821 0.463627274737191 24.53757286415311 -13.999999999999776 0.12327590743127519 2.812009866019146 0.22611521714798907 0.9996770307300087 0.00404946339487686 11.952376101206877 0.10846498869403108 5.284319863620555 0.21084490179568227 1.0000000000005154e-14 13.999999999999776 -2.585894648871157 TLEFAGQDLSAYLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLEFAGQDLSAYLLK 15 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 55316000.0 20637000.0 19919000.0 14760000.0 False True 26715003.316086497 18810490.13979177 12073831.450389255 1.0 0.7041170804745884 0.45194946478329545 24.67114686045144 -7.140024822078418 0.18613917999556479 1.1911466263750017 3.4690536899004044e-14 0.9999940109518431 0.0005481000404926572 0.08176877913520195 0.0073783121007041244 0.012324286331453937 0.032385085961334034 7.243945561587796e-08 7.140024822078418 -1.191146626374967 down TLEFAGQDLSAYLLK(ub)SLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLEFAGQDLSAYLLKSLFK 19 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 7577357060.0 2492326500.0 3225830560.0 1859200000.0 True False 3781041513.9736767 2650155893.0387974 1491728305.0836926 1.0 0.7009063199239043 0.3945284122299848 31.816136543479395 -7.037773336068757 0.24508296305471933 1.1068656906579115 5.1313085587852335e-15 0.9999869047686044 0.0008944913837917726 0.07239624506072687 0.00845961452334282 0.007362531685135041 0.028742165581785075 9.166988023045776e-08 7.037773336068757 -1.1068656906579064 down TLEFAGQDLSAYLLK(ub)SLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLEFAGQDLSAYLLKSLFK 19 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 6735326500.0 2492326500.0 2968300000.0 1274700000.0 True False 3226365785.350112 2803111495.654594 1042717679.5265044 1.0 0.8688139170030319 0.32318644223824516 31.587262865571844 -6.94397894403428 0.6214458549285867 1.0059661988820208 0.1570560519664373 0.9986399805753958 0.010807861834311415 0.08599741382747841 0.04668939321909719 0.010870026323823863 0.04620191685352235 1.1376824429180275e-07 6.94397894403428 -0.8489101469155835 down TLEHLQLSHDQLLEVK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLEHLQLSHDQLLEVKR 17 1 E9PB90;P52789 E9PB90 HK2 Hexokinase;Hexokinase-2 1 32897900.0 4164500.0 8405400.0 20328000.0 True False 6317850.9657315565 6905390.698310054 16310161.889921084 1.0 1.0929967699088428 2.5815996576032716 22.591002474510262 -6.919653107401305 0.8273104906710084 0.9667425976431109 2.8197335911654937 0.9940837296583017 0.05573803430794873 0.09837610668102681 0.1066799115318294 0.04793602791844771 0.14311522503096 1.2032251266310592e-07 6.919653107401305 1.8529909935223827 up TLEHLQLSHDQLLEVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLEHLQLSHDQLLEVKR 17 1 E9PB90;P52789 E9PB90 HK2 Hexokinase;Hexokinase-2 1 8461100.0 1713400.0 3386700.0 3361000.0 True False 1424768.016490047 3368455.174892681 4063769.5604918124 1.0 2.3642130760283053 2.8522324430773045 20.44229560530005 -9.816001533684242 0.2681997906692133 3.7804738933087593e-25 3.0914335955768486 0.9989814929141841 0.0250163262790576 1.2260567030092842 0.11619751363134825 1.1718461482270175 0.19862322817171832 1.527560663742051e-10 9.816001533684242 3.0914335955768486 TLEHLQLSHDQLLEVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLEHLQLSHDQLLEVKR 17 1 E9PB90;P52789 E9PB90 HK2 Hexokinase;Hexokinase-2 1 25659500.0 4164500.0 7700000.0 13795000.0 True False 5391027.344567623 7271488.231156016 11284451.54865312 1.0 1.348813086337482 2.0931913024006685 22.36212879660271 -6.958757022945604 0.4526179940577433 0.9766273637571754 2.4950154193780993 0.9997212642078533 0.007611897526594954 0.0801482622041846 0.02279539457219291 0.009988975011941103 0.0615491973000805 1.0996208781353792e-07 6.958757022945604 1.518388055620924 up TLELQGLINDLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLELQGLINDLQR 13 0 P15924 P15924 DSP Desmoplakin 0 8506300.0 3522600.0 1637800.0 3345900.0 False True 3410776.991173754 2291782.0810141684 2469508.4151515774 1.0 0.6719237543072246 0.7240310408865938 21.701668998785745 -10.379431016655937 5.841869044964192 1.0000715742344113 0.6979773975969304 0.9781631190957271 0.021272710666739584 1.9835154506640157e-05 2.107050276342532e-06 0.020602075467496733 0.006865737845080711 4.1741589554893624e-11 10.379431016655937 -0.30209417663748084 TLELQGLINDLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLELQGLINDLQR 13 0 P15924 P15924 DSP Desmoplakin 0 8088300.0 3522600.0 2410400.0 2155300.0 False True 2929197.9776396863 2397414.696773063 2605963.2650187486 1.0 0.8184543056065032 0.8896507798078583 21.48207427422002 -10.297604115306799 4.7013657839910445 1.0000727735802268 0.854052542714464 0.8485519682414279 0.029065838880698466 2.218203561776934e-05 3.3140455604379737e-06 0.028156893203040025 0.009380959160574564 5.039597881456384e-11 10.297604115306799 -0.14602023086576288 TLEQTGHVSSENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLEQTGHVSSENK 13 0 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 0 4515600.0 1509400.0 889000.0 2117200.0 False True 1461484.9232037875 1243982.3360737565 1562641.8053614665 1.0 0.8511769887757489 1.0692151390353917 20.479003515586633 -6.7229478364408095 1.748694520334539 0.9097446496133194 1.0689334082829236 0.5264087165495519 0.06260361827582202 0.3496155914607992 2.0909045726106807 0.02840863016632761 0.07107059042675172 1.8925709236439418e-07 6.7229478364408095 0.15918875866960425 TLEQTGHVSSENK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLEQTGHVSSENK 13 0 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 0 1758980.0 560590.0 449250.0 749140.0 False True 725694.8058809382 424248.8425775114 612804.2068255163 1.0 0.5846105541054626 0.8444379122730783 19.46900341850553 -10.413796268632472 6.060163357325339 1.0000799979531987 0.7145242331892705 0.6167938021710102 0.10607407478767122 0.00011468198115555777 1.1093224453982317e-05 0.10273443351780778 0.034235260426417516 3.8565923138076685e-11 10.413796268632472 -0.2855557647639282 TLESK(ub)LVLFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLESKLVLFGR 11 1 Q9UI14;M0QXU8;M0R1H9 Q9UI14 RABAC1 Prenylated Rab acceptor protein 1 1 5852040.0 1224000.0 587340.0 4040700.0 True False 1604675.8532328624 499711.1614333883 3622607.1251313263 1.0 0.311409410459218 2.257532022952197 20.613850469685612 -6.8110612630365726 1.4099884950532724 0.6251827532883992 2.2924387454529818 0.8625944491876579 0.2986733589621189 0.20535921559344603 0.804446265704882 0.16654755451092756 0.3850910554086836 1.5450364761368951e-07 6.8110612630365726 1.6672559921645824 TLESK(ub)LVLFGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLESKLVLFGR 11 1 Q9UI14;M0QXU8;M0R1H9 Q9UI14 RABAC1 Prenylated Rab acceptor protein 1 1 12899100.0 1564900.0 3708900.0 7625300.0 True False 1515223.1060829512 5189883.111657993 5628005.175903452 1.0 3.425161014785813 3.7143079149925167 20.531098805492 -10.10654740650701 0.48311753640640764 7.308916193730268e-24 3.711038991132291 0.999267680623805 0.032937031927783286 1.4121455707181771 0.22229193768125521 2.0528036574525905 0.060496194689148255 7.824427908931553e-11 10.10654740650701 3.711038991132291 TLESK(ub)LVLFGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLESKLVLFGR 11 1 Q9UI14;M0QXU8;M0R1H9 Q9UI14 RABAC1 Prenylated Rab acceptor protein 1 1 9480700.0 1564900.0 3942800.0 3973000.0 True False 1301283.6868246018 3921559.353815476 4803735.930923535 1.0 3.013608326547828 3.6915362726521472 20.311504080926277 -9.547342679171289 0.3165766500313947 3.5612193321939224e-21 3.917552004700931 0.9986356268981339 0.04222042615538205 0.9166594657462798 0.12923227100816068 1.1849065902038765 0.22323114399362767 2.835680657452829e-10 9.547342679171289 3.917552004700931 TLETLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLETLIR 7 0 P25205;P25205-2;J3KQ69;A0A499FHX9;Q7Z6P5 P25205 MCM3 DNA replication licensing factor MCM3 0 24921200.0 4831000.0 16332000.0 3758200.0 False True 7328980.19340838 13417426.997501569 3015390.1227224227 1.0 1.8307358791294162 0.4114337933993106 22.805181034767962 -6.748071082658763 1.6571960757747044 1.4896037945546048 0.4090480894588561 0.6405976411229142 0.3490493239524265 0.3033917895696437 1.6387590673191652 0.16643753934052294 0.404853431636528 1.7861951974441093e-07 6.748071082658763 -1.0805557050957486 TLETVPLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLETVPLER 9 0 P22626;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 38671300.0 6175300.0 18013000.0 14483000.0 False True 8095878.101690267 15325530.614124067 12984438.090745911 1.0 1.8930041215571642 1.6038332010007665 22.948756137097146 -10.040349904231302 4.977840758990397 0.9999896500788855 1.7484186612811266 0.8993090896833601 0.11805353399688855 1.6386363013752435e-05 3.159032185452825e-06 0.11430675144239984 0.03810161425687069 9.112763424973461e-11 10.040349904231302 0.748429011202241 TLETVPLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLETVPLER 9 0 P22626;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 45610000.0 14217000.0 10328000.0 21065000.0 False True 13765689.116992343 14452024.259808473 15547444.563545847 1.0 1.0498583933563428 1.1294345260459289 23.714573497957748 -6.964205562347472 0.37143898958414245 0.9939795002506477 1.1880895977794852 0.9998958029972342 0.0005440767347349579 0.07823163298896102 0.015817172318931857 0.001046634983909702 0.006753166072309424 1.0859115131095673e-07 6.964205562347472 0.19411009752883746 TLETVPLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLETVPLER 9 0 P22626;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 155741000.0 19213000.0 120680000.0 15848000.0 False True 29147525.658446483 99143711.12285635 12715635.853574855 1.0 3.4014451958849583 0.4362509532568185 24.796870082052344 -6.691266961488152 1.862201133213758 2.503767661249934 0.44641311113810195 0.37629121770361096 1.0153814804909986 0.4139181660778484 2.7840049199596453 0.4360704336682916 1.133627419958261 2.035790289574816e-07 6.691266961488152 -2.057354550111832 TLETVPLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLETVPLER 9 0 P22626;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 43733300.0 6175300.0 22846000.0 14712000.0 False True 8458475.291207632 21836588.178380854 11237328.603150984 1.0 2.581622269569012 1.3285288679428902 23.011966198620037 -6.587895217444635 2.2369171287306338 2.071859101641883 1.3320590148430258 0.0 0.6857317567951062 0.6756749003173287 6.370771136653532 0.2562270280649585 0.7647229328731795 2.5828832896522177e-07 6.587895217444635 -0.739800086798857 TLETVPLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLETVPLER 9 0 P22626;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 23415500.0 14217000.0 6571000.0 2627500.0 False True 11822065.419889681 6535600.718758624 3176898.10181263 1.0 0.5528307014578855 0.26872614801029204 23.494978773392024 -8.441219155665205 0.2258621014073363 1.263566231051293 4.0979189290367033e-19 0.9995695067058167 0.006245353450666091 0.136709654006088 0.05629441212766679 0.13209445391159322 0.1159164731941821 3.6206024781430308e-09 8.441219155665205 -1.263566231051293 down TLETVPLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLETVPLER 9 0 P22626;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 55470000.0 19213000.0 16281000.0 19976000.0 False True 24871607.244849976 15374948.03785079 16340572.971068827 1.0 0.6181726772416123 0.656997065376721 24.567996404144793 -9.935290943296643 6.998811823917749 1.0000000128088162 0.6375848716926801 0.9914663290334311 0.015849990084467826 3.1648773254118436e-09 4.901191965284402e-10 0.015346687366038517 0.005115562302890755 1.1606707947811248e-10 9.935290943296643 -0.36241514111613615 TLEVEIEPGVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLEVEIEPGVR 11 0 Q9UBS4;H7C2Y5 Q9UBS4 DNAJB11 DnaJ homolog subfamily B member 11 0 6235800.0 2140600.0 1889200.0 2206000.0 False True 2932037.667539887 1805728.8972510349 1684988.2339961305 1.0 0.6158614253977588 0.5746816463684493 21.483472207046898 -13.999999999999998 0.31540192909326964 4.832944760476226 0.5660801266808269 0.9996838011116935 0.0034057794469178003 17.663308288279307 0.178902631125132 44.56368008997464 0.013961574319304206 1.0000000000000041e-14 13.999999999999998 -4.266864633795399 TLFANIVLSGGSTLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLFANIVLSGGSTLFK 16 0 P42025 P42025 ACTR1B Beta-centractin 0 112966000.0 30845000.0 38417000.0 43704000.0 False True 46794120.0715548 31561186.196609024 35065885.243856296 1.0 0.6744690603936461 0.7493652020859803 25.47982392315377 -9.979619287526946 5.579980791858551 1.0000005831934764 0.7119171312395144 0.9517530799563225 0.030576221809292058 2.2182373608043264e-07 4.055794973416907e-08 0.029605359459102264 0.009868433154624085 1.048046887338694e-10 9.979619287526946 -0.288083451953962 TLFANIVLSGGSTLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLFANIVLSGGSTLFK 16 0 P42025 P42025 ACTR1B Beta-centractin 0 78935000.0 30845000.0 23993000.0 24097000.0 False True 39929460.54584907 22657768.45845797 19711593.25609958 1.0 0.5674448927863963 0.4936603947720684 25.25095024524622 -13.999999999999998 0.24881883472351596 3.9904041692092918 0.4636576876231195 0.9995404828953858 0.004787596643233928 13.951424963544966 0.15784455321760837 20.837755189787167 0.0342761040323798 1.0000000000000041e-14 13.999999999999998 -3.5267464815861724 TLFEK(ub)LPEYFFENK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLFEKLPEYFFENK 14 1 Q9BXW9;Q9BXW9-1;Q9BXW9-3;Q9BXW9-4 Q9BXW9 FANCD2 Fanconi anemia group D2 protein 1 15522700.0 6232200.0 2880700.0 6409800.0 True False 9454703.034849863 2366616.5779881687 5142900.2204848565 1.0 0.25031104300842266 0.543951534123094 23.172600714238747 -10.441450846445003 6.054244602031081 1.0002503972454004 0.39713128856873653 0.8489473303375004 0.11987822850853415 0.00040532804494262665 3.739435477817942e-05 0.11611838007458727 0.03869053188219991 3.6186714462616445e-11 10.441450846445003 -0.6031191086766639 TLFGLHLSQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLFGLHLSQK 10 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 385120000.0 107329000.0 129876000.0 147915000.0 False True 140709358.37551436 110499007.05268285 132610174.70086896 1.0 0.7852996298781462 0.9424403339752931 27.06814304242075 -10.43763391282319 4.841100844744105 1.000257918778009 0.8638699819266942 0.5001549340077253 0.06415242381003607 0.00017892062359065047 2.078431361138507e-05 0.06223249497422159 0.020705105752913296 3.650615447517989e-11 10.43763391282319 -0.13638793685131478 TLFGLHLSQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLFGLHLSQK 10 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 361354400.0 151345000.0 58081000.0 151928400.0 False True 146540635.81706467 81273046.18841375 112133794.28569764 1.0 0.5546109837401804 0.765206139993011 27.126725539532234 -10.060253410716694 4.933432279991851 1.0000078599443425 0.6599085618638455 0.7766475978382279 0.08597511252970323 7.432793817656158e-06 1.4157819137531777e-06 0.08324696740832878 0.027748348249962303 8.704555311694547e-11 10.060253410716694 -0.340099298080497 TLFGLHLSQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLFGLHLSQK 10 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 387812000.0 114733000.0 123847000.0 149232000.0 False True 174058349.1058421 101745535.2289724 119736229.78929074 1.0 0.5845484330493251 0.6879085686173034 27.37499577697952 -9.93842853246167 6.753671038207829 1.0000000246220497 0.6362285008333163 0.9429074873653367 0.04219659864775227 1.5620887680385222e-08 2.5240698850824754e-09 0.04085668339257231 0.013618893652443466 1.1523156693927076e-10 9.93842853246167 -0.36377152378873345 TLFGLHLSQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLFGLHLSQK 10 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 562732000.0 107329000.0 102783000.0 352620000.0 False True 147011431.75716534 98241707.20207144 269338418.4368611 1.0 0.6682589648153885 1.8320916626521702 27.131353103943642 -6.830521455153319 1.32550928545749 0.8228004584532246 1.8637598231454215 0.9069263124958796 0.14935190074914323 0.18016845351635455 0.6188977767828604 0.08846166444811736 0.20357983265311852 1.4773334960902962e-07 6.830521455153319 1.0409593646921969 TLFGLHLSQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLFGLHLSQK 10 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 272957960.0 151345000.0 50490000.0 71122960.0 False True 125850073.22031413 50218000.34851972 85994442.10058825 1.0 0.3990303625855481 0.6833086378110063 26.90713081496651 -10.470809021819901 6.2207428324428555 1.0002342563081097 0.5411695001983028 0.7764568462355518 0.11605611987680893 0.00037724202896848003 3.209142716366754e-05 0.11242695252169212 0.03745695162569436 3.382135307151858e-11 10.470809021819901 -0.4590647561098069 TLFGLHLSQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLFGLHLSQK 10 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 433465900.0 114733000.0 192161000.0 126571900.0 False True 148524130.22554398 181467071.4269053 103537112.93736629 1.0 1.221801946601776 0.6971063407685886 27.14612209907197 -6.791879330510446 1.489021897869744 1.1236627509361123 0.6912494573423762 0.807295101704731 0.09440613914315732 0.23256140179333865 1.0186284322157768 0.04990127136116158 0.11666278574052102 1.6148071715267122e-07 6.791879330510446 -0.43241329359373615 TLFILFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLFILFR 7 0 Q9NUD5;Q9NUD5-2 Q9NUD5 ZCCHC3 Zinc finger CCHC domain-containing protein 3 0 2283880.0 454880.0 759600.0 1069400.0 False True 623061.4286697854 726038.3603387072 816829.7449843418 1.0 1.1652757287331588 1.3109939203398373 19.249014882418653 -6.972607777906386 0.1856143099884962 0.8953975047458561 1.5848349872969805 0.9999962228782254 0.0002468448541978166 0.07546527911648307 0.0058912425736581875 0.00534219309988633 0.016083091602038878 1.0651045062236992e-07 6.972607777906386 0.6894374825511244 TLFK(ub)IGYDYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLFKIGYDYK 10 1 O60488-2;O60488 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 31631700.0 11722400.0 13197500.0 6711800.0 True False 11350278.828517353 18467330.574053314 4953778.230316016 1.0 1.6270376131777933 0.43644550985564734 23.43622440310026 -6.763596946722235 1.5988292147019216 1.3625830714151639 0.4312891871784774 0.7055206515393558 0.26388851336335895 0.2769136189957761 1.3958610609074644 0.13017585908778137 0.3117449439764143 1.7234673217861475e-07 6.763596946722235 -0.9312938842366865 TLFK(ub)IGYDYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLFKIGYDYK 10 1 O60488-2;O60488 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 50655900.0 28897000.0 9313800.0 12445100.0 True False 43838861.653678685 7651679.620948465 9985320.53011889 1.0 0.1745410198238207 0.2277732622028744 25.385707001106812 -9.96106594451268 6.106293229596074 1.0000003617640179 0.2011571410132965 0.9966807179469357 0.02173197194915225 1.0702331015208057e-07 1.822871161668897e-08 0.021041900765575668 0.007013963786558756 1.093790269428257e-10 9.96106594451268 -0.7988432207507213 TLFK(ub)IGYDYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLFKIGYDYK 10 1 O60488-2;O60488 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 15827600.0 5157100.0 4564500.0 6106000.0 True False 7063819.235387248 4362825.297217001 4663888.557017387 1.0 0.6176298050438185 0.6602502699464543 22.75201699391486 -10.324929658063443 8.708954870128302 1.0000004768943385 0.6389400377438216 0.9896575376662479 0.01739973193527615 1.6111892615538382e-07 1.2481630434647396e-08 0.016847240344756854 0.005615739334483157 4.732279006705445e-11 10.324929658063443 -0.3610604391505169 TLFK(ub)IGYDYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLFKIGYDYK 10 1 O60488-2;O60488 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 32705500.0 11722400.0 20983100.0 0.0 True False 9747694.990371736 20870059.875480764 0.0 1.0 2.1410251240006093 0.0 23.216629678534535 -6.766131049359761 1.6168562277402552 1.6609779598342993 7.852805303646331e-10 0.6986036241595226 0.48020752647334436 0.27655607846744273 1.4307017075126354 0.23528051877294562 0.5559102853289474 1.7134401949688294e-07 6.766131049359761 -1.6609779590490188 TLFK(ub)IGYDYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLFKIGYDYK 10 1 O60488-2;O60488 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 48069000.0 28897000.0 16461400.0 2710600.0 True False 37407736.145028375 15545308.619266417 2217298.6131046857 1.0 0.4155640041674226 0.0592737984599844 25.156833323199262 -8.395406854703925 0.4237304186437113 1.0771756213467092 2.5641682893431214e-17 0.9962604596259229 0.023714435613636783 0.15515086650647547 0.12663572534115897 0.08004450083618771 0.07788379377374931 4.0233993859197355e-09 8.395406854703925 -1.0771756213467092 TLFLAVQVQNEEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLFLAVQVQNEEGK 14 0 O95433;O95433-2;G3V3W9 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 0 83306000.0 20781000.0 34543000.0 27982000.0 False True 31526296.294601377 28378531.76430915 22451345.43505374 1.0 0.900154318766862 0.71214662278291 24.91005235655231 -6.961206874177554 0.4180808200719468 1.0084839813480975 0.5967471531209132 0.9998123635549907 0.0016346973161818195 0.07927283286702703 0.01955926314687784 0.0024292296885288136 0.01565864493245386 1.0934353892844518e-07 6.961206874177554 -0.41173682822718427 TLFLAVQVQNEEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLFLAVQVQNEEGK 14 0 O95433;O95433-2;G3V3W9 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 0 64017000.0 20781000.0 27221000.0 16015000.0 False True 26901414.15475081 25706127.42081791 13100434.327776704 1.0 0.9555678847566529 0.48697939269721097 24.68117867864476 -6.925344402914637 0.7840777102443909 1.0084880254741315 0.4012761767564598 0.995541069039369 0.01549702410562177 0.09512880525163071 0.09006265289259215 0.013745248790373381 0.04353505783832508 1.1875600985571403e-07 6.925344402914637 -0.6072118487176716 down TLFLAVQVQNEEGKCEVTEVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLFLAVQVQNEEGKCEVTEVSK 22 1 O95433;O95433-2;G3V3W9 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 0 33326700.0 5425700.0 13608000.0 14293000.0 False True 8231183.571802082 11179546.080210725 11467982.285155544 1.0 1.358194235700073 1.3932361227420444 22.972668461745 -12.098639055340985 0.3647951368664789 2.614607824406081e-09 1.3975183682703571 0.9996640164851771 0.003257038332272127 5.810767421808465 0.19025290934600247 4.425308730099449 0.009951459730111606 7.968213181086897e-13 12.098639055340985 1.3975183656557493 TLFPLIEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLFPLIEAK 9 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 23916000.0 5715300.0 7942700.0 10258000.0 False True 7492813.647043932 6757680.120402115 9196600.561684154 1.0 0.9018881876327136 1.2273894687494864 22.837076140130296 -6.82587176402066 1.3462106154345237 0.9474076997803903 1.2354352195428004 0.8973718427418091 0.04367550029987347 0.18596077928299082 0.6605367624568081 0.025483086767999912 0.0586651557221212 1.4932352584177297e-07 6.82587176402066 0.28802751976241014 TLFPLIEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLFPLIEAK 9 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 19408900.0 7175100.0 4849200.0 7384600.0 False True 6947330.3779511675 6785510.848243938 5450351.726748664 1.0 0.976707667419877 0.7845246202838598 22.72802727516224 -6.929525463420845 0.7506752913246995 1.0029745588418995 0.7455427910437088 0.9964441773375015 0.005757664647611634 0.09288500183871798 0.07889231762669364 0.005230777287865176 0.017434852950314786 1.1761820211195448e-07 6.929525463420845 -0.25743176779819066 TLFPLIEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLFPLIEAK 9 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 60435900.0 10420000.0 40455000.0 9560900.0 False True 15807901.804039594 33235489.173642304 7671183.924308662 1.0 2.102460502705629 0.4852752768459346 23.914142554501755 -6.723145712419417 1.7478876487491908 1.6684437439378317 0.4873156267360635 0.527411464277798 0.4637476143076577 0.3492193268705709 2.0866905978075936 0.21052706480880673 0.5265780225194154 1.8917088150115958e-07 6.723145712419417 -1.1811281172017682 TLFPLIEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLFPLIEAK 9 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 25196200.0 5715300.0 8736900.0 10744000.0 False True 7828400.860175051 8350874.86893531 8206488.479625745 1.0 1.0667408348259488 1.048296916088459 22.900286201653188 -10.047148656877265 4.246412029749871 0.9999964168873603 1.0575188754480374 0.9284047037272827 0.007529698397477847 3.686657971238168e-07 8.27265644419625e-08 0.007291254536845192 0.0024301996929350727 8.971216615812572e-11 10.047148656877265 0.05752245856067706 TLFPLIEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLFPLIEAK 9 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 19684400.0 7175100.0 6545600.0 5963700.0 False True 5966413.560825099 6510337.553600124 7210682.096966699 1.0 1.0911643129042172 1.208545472662396 22.508432550596517 -6.967670453963412 0.3088037327878229 0.9816590893371913 1.3217754470899596 0.9999580823208382 0.0005526382832565779 0.07706609299332391 0.011722044004503832 0.00186733253943353 0.010433361004957883 1.0772823538079626e-07 6.967670453963412 0.3401163577527684 TLFPLIEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLFPLIEAK 9 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 33746000.0 10420000.0 11770000.0 11556000.0 False True 13488895.408907358 11114989.153338471 9452926.574573051 1.0 0.8240103297115579 0.7007932293945163 23.685268876594204 -6.974947360040853 0.07389538407678221 1.4863051621598031 0.035415122147605615 0.9999999253984347 3.3035172846552675e-05 0.07472711473311144 0.0021368620484211037 0.01636645896457649 0.02544281112675241 1.0593821229684233e-07 6.974947360040853 -1.4508900400121976 TLFQIQAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLFQIQAER 9 0 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 0 8901100.0 3711000.0 5190100.0 0.0 False True 4865156.937375123 4415757.310851344 0.0 1.0 0.9076289557955676 0.0 22.214054912690486 -7.108314619839279 0.9809876259277965 0.9993899006799999 2.1131190122638873e-18 0.989551413407018 0.04612203911174672 0.08503823779286317 0.15547658503353112 0.038132265852223034 0.06728595663819854 7.792653757979589e-08 7.108314619839279 -0.9993899006799999 down TLFQIQAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLFQIQAER 9 0 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 0 10383300.0 2796800.0 1365900.0 6220600.0 False True 2708017.1148909223 1911310.9930743992 4591238.24600016 1.0 0.7057972353883686 1.6954243829382494 21.36880542621723 -6.827043975811417 1.3409875505128384 0.8424429986920972 1.7204954774876322 0.899839400359515 0.13131898275020426 0.18449364276998526 0.6498655401741281 0.07690890042205417 0.17703245389895972 1.4892102755507798e-07 6.827043975811417 0.878052478795535 TLFQIQAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLFQIQAER 9 0 Q16222;Q16222-3;Q16222-2 Q16222 UAP1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase 0 7436500.0 2796800.0 2799000.0 1840700.0 False True 2325663.1192479082 2783921.2314420007 2225581.859564797 1.0 1.1970440638635091 0.9569665705859083 21.149210701651505 -6.688643201491401 1.8717560820654344 1.1236937568214616 0.9578209953421187 0.3638967828098162 0.08335917519427129 0.41956385590171896 2.8489992231519246 0.03564608636711863 0.09296616842184888 2.0481266024071512e-07 6.688643201491401 -0.16587276147934282 TLFSNIVLSGGSTLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLFSNIVLSGGSTLFK 16 0 P61163;R4GMT0 P61163 ACTR1A Alpha-centractin 0 87680000.0 22895000.0 31140000.0 33645000.0 False True 34733388.84870307 25582823.702069532 26995051.002872642 1.0 0.7365484494906918 0.7772075198438526 25.04981984189679 -10.08651899145249 6.800591237879444 1.0000001491328951 0.7568779846673517 0.9794547232539562 0.016598995963528488 3.753865084043474e-08 5.0359042857165575e-09 0.01607191855163702 0.005357302910875731 8.193717917310063e-11 10.08651899145249 -0.24312216446554347 TLFSNIVLSGGSTLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLFSNIVLSGGSTLFK 16 0 P61163;R4GMT0 P61163 ACTR1A Alpha-centractin 0 65877000.0 22895000.0 22993000.0 19989000.0 False True 29638028.827920686 21713419.337528568 16351207.104460094 1.0 0.7326202246309076 0.5516968486465719 24.82094616398924 -8.091572343034702 0.1083519825126953 1.483888910420013 1.3203682992880667e-13 0.9999841234354374 0.0007337303651745655 0.09514117074934939 0.01940590253853659 0.11953704895204573 0.13132253988936288 8.098930217089008e-09 8.091572343034702 -1.483888910419881 TLFTNPIFPVGFSTGHNAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLFTNPIFPVGFSTGHNAPR 20 0 Q5T3J3 Q5T3J3 LRIF1 Ligand-dependent nuclear receptor-interacting factor 1 0 6181200.0 1944400.0 2251700.0 1985100.0 False True 2549127.2295963853 1915755.137057855 1779700.8944237877 1.0 0.7515337464584634 0.6981608739496207 21.28157195089418 -13.999999999999998 0.216152187422293 2.4745580066524866 0.6685372829116528 0.9994943400564185 0.002957596673982132 12.897779294328545 0.14731428662280774 8.101713157123614 0.030305887918638932 1.0000000000000041e-14 13.999999999999998 -1.8060207237408337 TLFTNPIFPVGFSTGHNAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLFTNPIFPVGFSTGHNAPR 20 0 Q5T3J3 Q5T3J3 LRIF1 Ligand-dependent nuclear receptor-interacting factor 1 0 6628300.0 1944400.0 1843400.0 2840500.0 False True 2663297.22543425 1761952.4926913835 2169632.4019338177 1.0 0.6615681028256609 0.8146414832013574 21.34478201241707 -10.107319207906267 4.5810392876563215 1.0000208006774003 0.7381047930065344 0.7960417195016747 0.06249194587834721 1.3606478009636495e-05 2.6514773916285025e-06 0.06051248826884297 0.02016918880145956 7.810535165982362e-11 10.107319207906267 -0.26191600767086587 TLFVK(ub)GLSEDTTEETLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLFVKGLSEDTTEETLK 17 1 P19338;H7BY16 P19338 NCL Nucleolin 1 46533000.0 20239000.0 15797000.0 10497000.0 True False 16829625.23972337 15711898.425540995 12691874.16735573 1.0 0.9335857573617161 0.7541388466214205 24.004499715459772 -6.953776458386536 0.5157203797138579 1.0031532845365998 0.6766215119427685 0.999465290832603 0.002401352383206947 0.08200380810347506 0.029953734293366886 0.002739340263730946 0.014816600467522286 1.1123041091204246e-07 6.953776458386536 -0.32653177259383126 TLGDFAAEYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLGDFAAEYAK 11 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 30676800.0 5710900.0 9959900.0 15006000.0 False True 7487045.204434277 8473921.743386118 13453323.067716176 1.0 1.131811216842574 1.7968801710651234 22.835965034339452 -6.939603429182787 0.6632487763339329 0.9924815329743085 1.9741513634528924 0.9981114202606359 0.015156387664067838 0.08794811311763923 0.05543833592308975 0.01470960312571164 0.057341929270185825 1.1492025230813406e-07 6.939603429182787 0.9816698304785839 TLGDFAAEYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLGDFAAEYAK 11 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 18009600.0 6954100.0 3301800.0 7753700.0 False True 6733345.901981889 4620225.958659531 5722773.3639860125 1.0 0.6861708912503093 0.8499152497574163 22.682892149444186 -10.215120733973778 5.328940807347682 1.0000152346360003 0.7680430705038204 0.7279353727469855 0.06684835443377696 1.2100260229902678e-05 1.782265631136915e-06 0.06472988927479623 0.021575213620260957 6.093674693830092e-11 10.215120733973778 -0.23197216413217991 TLGDFAAEYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLGDFAAEYAK 11 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 44088200.0 6762200.0 37326000.0 0.0 False True 10258751.78303998 30664883.670630865 0.0 1.0 2.989143739818991 0.0 23.290351868259016 -6.727414760417253 1.7330018755255059 2.200653422510983 0.0028541279692629235 0.5467784869716089 0.836394717256686 0.3412760506523389 2.0068261117447004 0.38267197531250274 0.9522412617946797 1.873204703435387e-07 6.727414760417253 -2.19779929454172 TLGDFAAEYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLGDFAAEYAK 11 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 22135900.0 5710900.0 8169800.0 8255200.0 False True 7822374.061269527 7808831.222084223 6305491.781180797 1.0 0.9982687047334698 0.8060841544769404 22.899175095862343 -6.908872410013526 0.9033794345981679 1.00616469299529 0.7818373774849178 0.9904890412997028 0.00887542481003278 0.10516838956442574 0.14284685137915618 0.007226157843853302 0.01979501220022488 1.233467156373274e-07 6.908872410013526 -0.22432731551037233 TLGDFAAEYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLGDFAAEYAK 11 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 14350500.0 6954100.0 4726100.0 2670300.0 False True 5782642.268865083 4700639.561242594 3228647.3839277914 1.0 0.812887836163027 0.5583342758917463 22.463297424878462 -6.9668294614340045 0.32512930584128075 1.0328278854803146 0.3301213074217764 0.9999460387317372 0.0013296466409048887 0.07734553162286384 0.012699763978779024 0.0037815721526167742 0.022292084948098558 1.0793704857499978e-07 6.9668294614340045 -0.7027065780585382 TLGDFAAEYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLGDFAAEYAK 11 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 27174000.0 6762200.0 9043800.0 11368000.0 False True 8753801.20288996 8540504.579860883 9299140.645530168 1.0 0.975633828312361 1.0622974442759987 23.061478190351465 -6.831650217031457 1.3206828891700262 0.9869949350198746 1.06470637627447 0.9091047433974129 0.011002037153822043 0.17878498145166857 0.6093132604114389 0.0065399703872589966 0.015048709921609326 1.473498788012178e-07 6.831650217031457 0.07771144125459539 TLGECGFTSQTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLGECGFTSQTAR 13 0 B8ZZU8;Q15370;Q15370-2;I3L0M9 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 0 11032800.0 2196000.0 6407100.0 2429700.0 False True 2878977.266094251 5451185.654680191 2178297.9513281337 1.0 1.893445189331249 0.7566221439057453 21.457124965998158 -6.697094476755411 1.8408913000211242 1.5563569079057222 0.7601456569139726 0.4039314845054053 0.377337773363414 0.40161038333020266 2.6438370568726293 0.1636402895565772 0.422408794073209 2.0086558005496892e-07 6.697094476755411 -0.7962112509917496 TLGECGFTSQTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLGECGFTSQTAR 13 0 B8ZZU8;Q15370;Q15370-2;I3L0M9 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 0 9986500.0 2196000.0 3143400.0 4647100.0 False True 3007920.5446685934 3004514.194166262 3549550.690028741 1.0 0.9988675397332656 1.1800679696543723 21.52033502752105 -6.905492761589591 0.925889862970592 0.9935590562764354 1.201360189254202 0.9891064271845539 0.008887614389267728 0.10747432212350423 0.15549582219759242 0.007117994432248027 0.01908609534448519 1.243103354545067e-07 6.905492761589591 0.2078011329777667 TLGECGFTSQTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLGECGFTSQTAR 13 0 B8ZZU8;Q15370;Q15370-2;I3L0M9 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 0 6048800.0 3111700.0 1788400.0 1148700.0 False True 2587516.421683247 1778765.5342303915 1388887.8590112904 1.0 0.6874412542175319 0.5367648480884935 21.303136588035 -13.999999999594635 0.09635659954596497 2.5615322124945634 0.1969117288084283 0.9998118188355434 0.002646532746780588 12.109178334888238 0.09168587096858044 3.7970284804447765 0.3038039147370124 1.0000000009333865e-14 13.999999999594635 -2.364620483686135 TLGECGFTSQTARPQAPATVGLAFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLGECGFTSQTARPQAPATVGLAFR 25 1 B8ZZU8;Q15370;Q15370-2;I3L0M9 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 0 34930100.0 8432100.0 14928000.0 11570000.0 False True 11054564.756572567 12700800.588888235 10372847.38727682 1.0 1.1489190998077865 0.9383315956523366 23.39813888828964 -6.716733027230613 1.7709812060192318 1.0909172448818898 0.9387174742285734 0.49701886427930975 0.06269250157999089 0.361744430551951 2.2154714689945125 0.02812702808576576 0.07088450842715288 1.919848561742161e-07 6.716733027230613 -0.15219977065331636 TLGECGFTSQTARPQAPATVGLAFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLGECGFTSQTARPQAPATVGLAFR 25 1 B8ZZU8;Q15370;Q15370-2;I3L0M9 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 0 26444500.0 13858000.0 5433200.0 7153300.0 False True 13418085.375485694 7602705.093763701 5279636.135599927 1.0 0.5666013355119606 0.393471645756973 23.67767549250426 -13.999999999999988 0.12656585608262952 3.0596784782767945 0.1400990737401387 0.9996614284239252 0.004693920087454727 11.943363161459617 0.11027904081191595 6.139912339193609 0.22508447172686524 1.0000000000000286e-14 13.999999999999988 -2.919579404536656 TLGECGFTSQTARPQAPATVGLAFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLGECGFTSQTARPQAPATVGLAFR 25 1 B8ZZU8;Q15370;Q15370-2;I3L0M9 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 0 127245000.0 24829000.0 73566000.0 28850000.0 False True 37667408.24304215 60437572.52621859 23147784.854595773 1.0 1.6045057344072116 0.614530861938758 25.166813434328677 -6.7414592385249295 1.681351006984321 1.3590782917961348 0.6137674453863595 0.6114214927141143 0.25398187052333543 0.3152107623982594 1.7501947338372645 0.11947450356400559 0.2927116955917154 1.813596886219493e-07 6.7414592385249295 -0.7453108464097753 TLGECGFTSQTARPQAPATVGLAFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLGECGFTSQTARPQAPATVGLAFR 25 1 B8ZZU8;Q15370;Q15370-2;I3L0M9 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 0 38494100.0 8432100.0 12899000.0 17163000.0 False True 11549675.238934457 12329079.52871115 13109452.883080479 1.0 1.067482788360082 1.135049480775697 23.461348949812532 -6.971110060857419 0.23013967034990113 0.9725688956560788 1.2318942663308106 0.9999897814880233 0.00017614811437638656 0.07594414843427 0.007729307153416555 0.0017343130554698968 0.00670889146862894 1.0687839888620957e-07 6.971110060857419 0.2593253706747317 TLGECGFTSQTARPQAPATVGLAFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLGECGFTSQTARPQAPATVGLAFR 25 1 B8ZZU8;Q15370;Q15370-2;I3L0M9 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 0 23926700.0 13858000.0 3805300.0 6263400.0 False True 11523541.0134931 3784800.093607092 7573047.981310459 1.0 0.3284407188012268 0.6571806333177497 23.458080767938537 -10.577670476435024 6.52216053894485 1.000892625214159 0.49281067605979506 0.7604078750653608 0.1342075081086069 0.0017447157078904945 0.00011297543737144483 0.1301510950046707 0.0433152869867193 2.6444144617731495e-11 10.577670476435024 -0.508081949154364 TLGECGFTSQTARPQAPATVGLAFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLGECGFTSQTARPQAPATVGLAFR 25 1 B8ZZU8;Q15370;Q15370-2;I3L0M9 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 0 85740000.0 24829000.0 37630000.0 23281000.0 False True 32141629.95276016 35535857.42057156 19044096.88323255 1.0 1.1056022197007442 0.5925056355642953 24.937939756421127 -6.853054398962112 1.2202707486815605 1.0565351438169555 0.5707538708917708 0.944634666811184 0.05205430506812715 0.15412602179404128 0.44010923522315387 0.033352040009071215 0.07734412836256656 1.4026380015917028e-07 6.853054398962112 -0.4857812729251847 TLGPAEKPPLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLGPAEKPPLR 11 1 B7ZKW8;Q6JBY9 B7ZKW8 RCSD1 CapZ-interacting protein 0 615750.0 615750.0 0.0 0.0 False True 596203.3532945095 0.0 0.0 1.0 0.0 0.0 19.185444964102953 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 TLGTMIAGDTSGDYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLGTMIAGDTSGDYR 15 0 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 0 5610300.0 1475800.0 1739200.0 2395300.0 False True 1934788.091667532 1479718.139348502 2147457.3333400358 1.0 0.764795972086628 1.10991862240025 20.883744132674863 -6.723195779017278 1.7477868911623418 0.8574009109606077 1.1094828470966198 0.5276625100632562 0.09893709108185761 0.3490968175052985 2.0857597017054488 0.04491745879439499 0.11233923685121446 1.8914907464673782e-07 6.723195779017278 0.25208193613601215 TLGYVDEAGTVK(ub)LAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLGYVDEAGTVKLAGR 16 1 Q15477;H7C4L3 Q15477 SKIV2L Helicase SKI2W 1 5523600.0 1375700.0 1632800.0 2515100.0 True False 1803556.0222977526 1389192.604604549 2254861.57854278 1.0 0.7702519840967849 1.2502309607605417 20.78241280633148 -6.776534370163248 1.5492056567200507 0.8693232618827308 1.2536382713221585 0.7549691178548239 0.09702614556962723 0.25600952756779805 1.2133301175837206 0.0493391349989642 0.11676954049767337 1.6728832388029063e-07 6.776534370163248 0.38431500943942776 TLGYVDEAGTVK(ub)LAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLGYVDEAGTVKLAGR 16 1 Q15477;H7C4L3 Q15477 SKIV2L Helicase SKI2W 1 8664300.0 1911900.0 1642300.0 5110100.0 True False 1851207.7810211482 2298078.9544813624 3771611.51028605 1.0 1.2413943902146494 2.0373788123370917 20.82003540284993 -6.949308373348962 0.5663865510035583 0.9899169715807488 2.3273169521930215 0.999145877992053 0.012953344251876256 0.08376468084639815 0.03712106761177955 0.013780519509643178 0.06626356757589666 1.1238067250307494e-07 6.949308373348962 1.3373999806122727 up TLGYVDEAGTVK(ub)LAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLGYVDEAGTVKLAGR 16 1 Q15477;H7C4L3 Q15477 SKIV2L Helicase SKI2W 1 25726000.0 3559900.0 6435100.0 15731000.0 True False 5400628.563550909 5286706.1273342185 12621760.954857761 1.0 0.9789057079419313 2.337091100847521 22.36469589747886 -6.903373133521728 0.9396934054411513 0.9486380624497398 2.489840007802098 0.9881711391878213 0.06910006074665792 0.10896490586602384 0.16374618520506085 0.05478144779789984 0.14510280269468878 1.249185304383724e-07 6.903373133521728 1.5412019453523582 up TLGYVDEAGTVK(ub)LAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLGYVDEAGTVKLAGR 16 1 Q15477;H7C4L3 Q15477 SKIV2L Helicase SKI2W 1 6469100.0 1375700.0 1753500.0 3339900.0 True False 1884333.4668946208 1676024.5719509257 2551084.4073996707 1.0 0.8894522128893736 1.3538391437710091 20.84562286785437 -6.843903288443915 1.2641759642494441 0.941187602152199 1.3703288366976496 0.9309530749162358 0.05204587931419075 0.16429035636741363 0.508333148318787 0.03226010633746481 0.07441615874919223 1.4325068638225384e-07 6.843903288443915 0.4291412345454506 TLGYVDEAGTVK(ub)LAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLGYVDEAGTVKLAGR 16 1 Q15477;H7C4L3 Q15477 SKIV2L Helicase SKI2W 1 9220200.0 1911900.0 3865900.0 3442400.0 True False 1589829.5615310604 3845073.629378935 4162189.924140743 1.0 2.4185445549748095 2.618010147032624 20.600440678284205 -10.473877210910116 0.403996607170371 1.2588332346852494e-18 2.634795120617476 0.9992835205364665 0.0192814458938444 1.9252435838403064 0.1907191209963818 2.0533653052724548 0.05025254847764081 3.358325515404989e-11 10.473877210910116 2.634795120617476 TLGYVDEAGTVK(ub)LAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLGYVDEAGTVKLAGR 16 1 Q15477;H7C4L3 Q15477 SKIV2L Helicase SKI2W 1 21825300.0 3559900.0 4595400.0 13670000.0 True False 4608360.726119889 4339661.950318742 11182200.266044786 1.0 0.9416931981304805 2.4265028131727626 22.13582221957131 -6.897760167010023 0.9753327382184651 0.934416127251823 2.5754520251417765 0.9854182257136365 0.0829122856573734 0.11307235438011137 0.18686993091259702 0.06401721565199898 0.1647643906617773 1.2654349731305128e-07 6.897760167010023 1.6410358978899535 up TLHEVLEK(ub)VFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLHEVLEKVFK 11 1 C9JBT1;Q8N3F0-3;Q8N3F0-2;Q8N3F0 C9JBT1 MTURN Maturin 1 28853600.0 9757400.0 11043000.0 8053200.0 True False 12792045.890796022 9395427.445276856 7219932.115749165 1.0 0.7344741822757953 0.5644079279721755 23.608743683744756 -8.938698728655373 0.09459185916441783 1.6381111067248275 1.3904856299575143e-09 0.9999733276042252 0.0009257114490360481 0.426939613854933 0.029315192993412488 0.2798979709142123 0.21038948944112468 1.1515989794799834e-09 8.938698728655373 -1.6381111053343418 TLHEVLEK(ub)VFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLHEVLEKVFK 11 1 C9JBT1;Q8N3F0-3;Q8N3F0-2;Q8N3F0 C9JBT1 MTURN Maturin 1 94471000.0 17843000.0 41799000.0 34829000.0 True False 17276583.73176441 58489558.67890538 25706240.052396804 1.0 3.3854817356840954 1.487923796249937 24.042314631683798 -6.588924370364379 2.2322167136861166 2.615557941000498 1.4932500773117034 0.0 1.033973845233843 0.672728188479904 6.317445966415135 0.3868542559996244 1.1532641018286878 2.576769846095049e-07 6.588924370364379 -1.1223078636887944 TLHEVLEK(ub)VFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLHEVLEKVFK 11 1 C9JBT1;Q8N3F0-3;Q8N3F0-2;Q8N3F0 C9JBT1 MTURN Maturin 1 40016300.0 18362000.0 13051000.0 8603300.0 True False 27856496.44201292 10721947.082071586 6902853.9840396475 1.0 0.38489933952716465 0.24780050852442537 24.7315104834005 -13.999999999999998 0.21092998935205448 4.571013837005767 0.16777363539379425 0.999490554113423 0.0073829390454481815 12.768601326363232 0.14556288048085483 18.90520857344572 0.08068455227596016 1.0000000000000041e-14 13.999999999999998 -4.403240201611973 TLHEVLEK(ub)VFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLHEVLEKVFK 11 1 C9JBT1;Q8N3F0-3;Q8N3F0-2;Q8N3F0 C9JBT1 MTURN Maturin 1 25595800.0 9757400.0 7664900.0 8173500.0 True False 13364974.463820288 7326239.373565243 6243087.638516476 1.0 0.5481671059976785 0.4671230502846716 23.671953745267647 -13.999999999999998 0.24168602349478405 4.015321228211208 0.43185851508811723 0.9995277891135455 0.005094577553408723 13.683498546356574 0.15558882662379106 19.93303508597821 0.03921253533743888 1.0000000000000041e-14 13.999999999999998 -3.583462713123091 TLHEVLEK(ub)VFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLHEVLEKVFK 11 1 C9JBT1;Q8N3F0-3;Q8N3F0-2;Q8N3F0 C9JBT1 MTURN Maturin 1 46023300.0 17843000.0 20679000.0 7501300.0 True False 14837245.07892606 20567598.122539856 9069787.14790754 1.0 1.3862140857774767 0.6112851206313041 23.822719907118074 -6.771199180890948 1.569908396192601 1.2211823497857377 0.606731888309041 0.7351151631589394 0.16282293226322495 0.2644923573739546 1.2866629694886291 0.08174330589644317 0.19436614901464472 1.693560902860028e-07 6.771199180890948 -0.6144504614766967 TLHGSALFQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLHGSALFQR 10 0 Q8TCS8;H7C3C5 Q8TCS8 PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial 0 11510600.0 3873200.0 3854800.0 3782600.0 False True 5077802.708122152 3279678.865892713 3391212.8372613103 1.0 0.6458854458143348 0.6678504526843723 22.275772911229005 -10.436329846695267 5.979684691251728 1.0001461811921062 0.6568679492493539 0.99693614012848 0.008967176504720153 1.7482783479889787e-05 1.6480062626253341e-06 0.008686094828483716 0.0028941437721069045 3.6615937094053485e-11 10.436329846695267 -0.3432782319427523 TLHGSALFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLHGSALFQR 10 0 Q8TCS8;H7C3C5 Q8TCS8 PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial 0 7002800.0 2318900.0 1013600.0 3670300.0 False True 2245287.7888016845 1418335.7658541705 2708938.323360185 1.0 0.6316944192758203 1.2064993792203145 21.098468942962036 -6.733643999486102 1.7098672893001856 0.7792604090202926 1.2063962646478326 0.5761026974253285 0.15478768782646152 0.3294519268485492 1.8885751317787614 0.0716898895621481 0.1771696147989268 1.8465284379851476e-07 6.733643999486102 0.42713585562754 TLHGSALFQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLHGSALFQR 10 0 Q8TCS8;H7C3C5 Q8TCS8 PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial 0 8086690.0 3873200.0 1950690.0 2262800.0 False True 5305226.709294347 1864502.0657307971 1728373.24382885 1.0 0.35144625628615145 0.32578687745820056 22.338982972751896 TLHGSALFQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLHGSALFQR 10 0 Q8TCS8;H7C3C5 Q8TCS8 PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial 0 5924690.0 2318900.0 2100700.0 1505090.0 False True 1928268.0946882034 2089383.112143698 1819797.360250114 1.0 1.0835542619303393 0.943747067777093 20.878874218396312 -6.744812906635778 1.668827091104976 1.0494344178556134 0.9435717833130056 0.6264577114524408 0.03510480700428583 0.3091740333422405 1.6923435433457348 0.01662855394726824 0.040595335239596506 1.799646032773193e-07 6.744812906635778 -0.1058626345426078 TLHGSALFQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLHGSALFQR 10 0 Q8TCS8;H7C3C5 Q8TCS8 PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial 0 11277700.0 3194300.0 4667600.0 3415800.0 False True 4135084.3190664873 4407843.956849847 2794159.449067725 1.0 1.0659622916334959 0.6757200660175458 21.979485317211367 -6.863413949554059 1.1684534401916573 1.036163689051612 0.6555606353814419 0.9576516490744579 0.03509778699355348 0.1433212718217943 0.3699121574977704 0.023394506970142795 0.054833823951451095 1.3695757271536963e-07 6.863413949554059 -0.38060305367017 TLHLQTGNLLNWGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLHLQTGNLLNWGR 14 0 P48507-2;P48507 P48507-2 GCLM Glutamate--cysteine ligase regulatory subunit 0 32649600.0 9599600.0 12689000.0 10361000.0 False True 12585168.562658641 10795850.661334591 9288943.109729918 1.0 0.8578232867986272 0.7380865074220039 23.585221203943096 -6.973110167785249 0.16803234042292065 1.1086352336259324 0.4840739723210008 0.9999975878264472 0.00016617099635265686 0.07530583121236054 0.005230357543076294 0.005138465212911882 0.013965017385671545 1.0638731105552189e-07 6.973110167785249 -0.6245612613049316 TLHLQTGNLLNWGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLHLQTGNLLNWGR 14 0 P48507-2;P48507 P48507-2 GCLM Glutamate--cysteine ligase regulatory subunit 0 36719900.0 16924000.0 9007900.0 10788000.0 False True 16386756.883729253 12604801.44557792 7962299.166937212 1.0 0.7692065937765565 0.4858984131779695 23.966027021960343 -6.968374168016374 0.29444456826082166 1.0524946617679791 0.1938026486226314 0.9999667757428667 0.0012118531131379983 0.07683388381396469 0.010908663917661415 0.004834639706716525 0.025562389999198774 1.0755381804473548e-07 6.968374168016374 -0.8586920131453477 down TLHLQTGNLLNWGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLHLQTGNLLNWGR 14 0 P48507-2;P48507 P48507-2 GCLM Glutamate--cysteine ligase regulatory subunit 0 59929000.0 18007000.0 20961000.0 20961000.0 False True 27317935.488036554 17220345.780959498 16818049.16246733 1.0 0.6303677592510923 0.6156412943369209 24.703345122447335 TLHLQTGNLLNWGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLHLQTGNLLNWGR 14 0 P48507-2;P48507 P48507-2 GCLM Glutamate--cysteine ligase regulatory subunit 0 46431600.0 9599600.0 16202000.0 20630000.0 False True 13148831.539435623 15486142.0671508 15757618.888186814 1.0 1.1777580403783543 1.198404500120561 23.648431265465987 -13.205442733445574 0.31416652330714884 1.7396680135983267e-06 1.2028846561492479 0.9996409144469807 0.0016876773819395911 10.749814330422128 0.1763720717061065 6.916891576243572 0.007037458209131414 6.230993045810545e-14 13.205442733445574 1.2028829164812342 TLHLQTGNLLNWGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLHLQTGNLLNWGR 14 0 P48507-2;P48507 P48507-2 GCLM Glutamate--cysteine ligase regulatory subunit 0 33327700.0 16924000.0 7084700.0 9319000.0 False True 14073055.860323085 7046533.314897162 11267559.81381232 1.0 0.5007109603511082 0.8006477005168118 23.74643229739462 -10.32702859995483 5.917184713944807 1.0000364022478805 0.6506793304339613 0.6439430375486102 0.12244866141995482 5.8809060143319936e-05 6.68844130409443e-06 0.1185727324226351 0.0395201355370726 4.7094631175755886e-11 10.32702859995483 -0.3493570718139192 TLHLQTGNLLNWGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLHLQTGNLLNWGR 14 0 P48507-2;P48507 P48507-2 GCLM Glutamate--cysteine ligase regulatory subunit 0 80785500.0 18007000.0 31236500.0 31542000.0 False True 23310416.471035965 29498161.31590972 25801679.648250576 1.0 1.2654497766079063 1.1068733877110302 24.474471444539784 -10.242848996886773 3.897715556392175 0.9998030051071602 1.1861615819932256 0.6475846862255799 0.06473854014234727 8616026.356690554 7606646.930826554 13345.396109393932 0.022161724152755746 5.71677372923198e-11 10.242848996886773 0.18635857688606539 TLHNLVIQYASQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLHNLVIQYASQGR 14 0 Q07866-5;G3V3H3;F8W6L3;Q07866-9;G5E9S8;Q07866-4;Q07866-6;G3V2E7;Q07866-10;G3V5R9;Q07866-7;Q07866;Q07866-3;Q07866-2;Q07866-8;E7EVH7;A8MZ87;Q9H0B6;Q9H0B6-2;E9PQ02;A8MX29 Q07866-5 KLC1;KLC2 Kinesin light chain 1;Kinesin light chain 2 0 37320100.0 11932000.0 8769100.0 16619000.0 False True 15642967.549652355 7460784.461684072 14899425.300704729 1.0 0.47694175916448023 0.9524679542684246 23.89901088932817 -10.452438778122536 8.901804804463664 1.0000038107570595 0.7147048567164527 0.32429272021971545 0.19413275622197065 1.4682494419185798e-05 9.03067074662293e-07 0.1879707442725329 0.06265607765008638 3.528265205677718e-11 10.452438778122536 -0.2852989540406068 TLHNLVIQYASQGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLHNLVIQYASQGR 14 0 Q07866-5;G3V3H3;F8W6L3;Q07866-9;G5E9S8;Q07866-4;Q07866-6;G3V2E7;Q07866-10;G3V5R9;Q07866-7;Q07866;Q07866-3;Q07866-2;Q07866-8;E7EVH7;A8MZ87;Q9H0B6;Q9H0B6-2;E9PQ02;A8MX29 Q07866-5 KLC1;KLC2 Kinesin light chain 1;Kinesin light chain 2 0 31705100.0 11824000.0 5916100.0 13965000.0 False True 11448653.592130374 8278429.5820539305 10307147.558980178 1.0 0.7230919789331729 0.9002934254264755 23.448674605750142 -10.094340285133061 4.767095974403129 1.0000090677633098 0.811692702600489 0.600909958825195 0.07234218760659245 6.972191924825782e-06 1.324551630776244e-06 0.07004839373875145 0.023348340651246302 8.047476457773522e-11 10.094340285133061 -0.1883163651628208 TLHNLVIQYASQGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLHNLVIQYASQGR 14 0 Q07866-5;G3V3H3;F8W6L3;Q07866-9;G5E9S8;Q07866-4;Q07866-6;G3V2E7;Q07866-10;G3V5R9;Q07866-7;Q07866;Q07866-3;Q07866-2;Q07866-8;E7EVH7;A8MZ87;Q9H0B6;Q9H0B6-2;E9PQ02;A8MX29 Q07866-5 KLC1;KLC2 Kinesin light chain 1;Kinesin light chain 2 0 27148900.0 8708700.0 7961200.0 10479000.0 False True 13211734.591251401 6540461.65886049 8407821.056891145 1.0 0.49504942849756295 0.6363903996723238 23.655316557133244 -10.519720835224971 9.439133870584953 1.0000127160018801 0.5657199140849642 0.9264034049122414 0.05770220985459826 1.544151859054824e-05 7.856387624341152e-07 0.05587155611768736 0.01862330815051871 3.0218935713739285e-11 10.519720835224971 -0.4342928019169159 TLHNLVIQYASQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLHNLVIQYASQGR 14 0 Q07866-5;G3V3H3;F8W6L3;Q07866-9;G5E9S8;Q07866-4;Q07866-6;G3V2E7;Q07866-10;G3V5R9;Q07866-7;Q07866;Q07866-3;Q07866-2;Q07866-8;E7EVH7;A8MZ87;Q9H0B6;Q9H0B6-2;E9PQ02;A8MX29 Q07866-5 KLC1;KLC2 Kinesin light chain 1;Kinesin light chain 2 0 31884700.0 11932000.0 7539700.0 12413000.0 False True 16343582.850175602 7206571.1235462865 9481305.053759728 1.0 0.44094193969646356 0.5801240242532167 23.962220950851062 -10.207848883347607 8.153900764521703 1.0000001700598686 0.5105329819749908 0.9428242562386795 0.05682084808349132 1.7572228609788977e-07 1.7092172262091645e-08 0.05501656844126396 0.018338849862061947 6.196566526474332e-11 10.207848883347607 -0.4894671880848779 TLHNLVIQYASQGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLHNLVIQYASQGR 14 0 Q07866-5;G3V3H3;F8W6L3;Q07866-9;G5E9S8;Q07866-4;Q07866-6;G3V2E7;Q07866-10;G3V5R9;Q07866-7;Q07866;Q07866-3;Q07866-2;Q07866-8;E7EVH7;A8MZ87;Q9H0B6;Q9H0B6-2;E9PQ02;A8MX29 Q07866-5 KLC1;KLC2 Kinesin light chain 1;Kinesin light chain 2 0 23214700.0 11824000.0 6053400.0 5337300.0 False True 9832179.892014887 6020789.132694182 6453304.753113048 1.0 0.6123554693688944 0.6563452686981489 23.22907988118442 -10.454370440473356 9.281084296495251 1.0000031552313806 0.6343503692519759 0.9892614394067849 0.01795876037401654 1.17248673715287e-06 6.895850451703709e-08 0.01738864490730976 0.005796164987257984 3.512606976232357e-11 10.454370440473356 -0.36565278597940476 TLHNLVIQYASQGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLHNLVIQYASQGR 14 0 Q07866-5;G3V3H3;F8W6L3;Q07866-9;G5E9S8;Q07866-4;Q07866-6;G3V2E7;Q07866-10;G3V5R9;Q07866-7;Q07866;Q07866-3;Q07866-2;Q07866-8;E7EVH7;A8MZ87;Q9H0B6;Q9H0B6-2;E9PQ02;A8MX29 Q07866-5 KLC1;KLC2 Kinesin light chain 1;Kinesin light chain 2 0 33327000.0 8708700.0 15367000.0 9251300.0 False True 11273583.82414122 14511812.941321367 7567658.3263540855 1.0 1.287240434603042 0.6712735226351645 23.426442879225693 -6.779908047454336 1.5363153020996734 1.162661753379718 0.6664154640289125 0.7670396650875888 0.12146491204457416 0.2507153562667372 1.168838736061377 0.06227292288477737 0.14694394639066918 1.659938326586597e-07 6.779908047454336 -0.4962462893508056 TLHPAVHAGILAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLHPAVHAGILAR 13 0 P31939-2;P31939;C9JLK0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 99015000.0 44044000.0 29283000.0 25688000.0 False True 57742110.52270273 24914090.54424 23030052.176695503 1.0 0.4314717685015066 0.39884326998474834 25.78312050446625 -13.879685288475251 0.40771906344488673 9.999340737235745 0.39724621976990465 0.9998465492081509 0.003419187539402171 25.193572361557216 0.21114587564122125 200.4043868662777 0.008178461795611318 1.3192123595919271e-14 13.879685288475251 -9.60209451746584 TLHPAVHAGILAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLHPAVHAGILAR 13 0 P31939-2;P31939;C9JLK0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 107491000.0 35683000.0 16567000.0 55241000.0 False True 34550262.696886726 23182289.495763697 40771724.90552276 1.0 0.6709728866360434 1.180069895943125 25.042193344146487 -6.732227056581986 1.715157281366125 0.8024856422155007 1.1798897671054305 0.5695454497555892 0.13829243599060703 0.3320758040440691 1.9148152384058263 0.06387035873704212 0.1580890630345582 1.852562818660857e-07 6.732227056581986 0.3774041248899298 TLHPAVHAGILAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLHPAVHAGILAR 13 0 P31939-2;P31939;C9JLK0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 132959000.0 33552000.0 56692000.0 42715000.0 False True 50900836.9797636 46574869.66338228 34272361.52735043 1.0 0.9150118628088341 0.6733162667045324 25.601186043432477 -6.952645572410509 0.5290022225701962 1.0038394138441775 0.5735353845934698 0.9993928809574691 0.0034098542878422847 0.0824404809979346 0.03169794449202852 0.003809823517924377 0.019984392611776234 1.1152042801800572e-07 6.952645572410509 -0.43030402925070776 TLHPAVHAGILAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLHPAVHAGILAR 13 0 P31939-2;P31939;C9JLK0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 95297000.0 44044000.0 25828000.0 25425000.0 False True 60328257.04434587 24686833.558225553 19420138.64431169 1.0 0.40920846660759397 0.32190783549467383 25.846330565989142 -13.999999999999998 0.2692636137635648 5.54196842413442 0.2927221653601749 0.9995817474049186 0.006159800803071467 14.846964330607143 0.1642576589189221 36.89759109511507 0.03639150645429532 1.0000000000000041e-14 13.999999999999998 -5.249246258774245 TLHPAVHAGILAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLHPAVHAGILAR 13 0 P31939-2;P31939;C9JLK0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 72970000.0 35683000.0 23627000.0 13660000.0 False True 29671995.524929605 23499716.661407683 16516242.843296112 1.0 0.7919830212182345 0.5566273029874116 24.822598619580763 -6.96951998480843 0.2694049505682721 1.0589313897292876 0.2826090642627598 0.999978391711992 0.0008419151357762909 0.07645876577458463 0.009586155160651743 0.0046303677743856795 0.021907352600689267 1.0727042843649475e-07 6.96951998480843 -0.7763223254665278 TLHPAVHAGILAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLHPAVHAGILAR 13 0 P31939-2;P31939;C9JLK0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 131517000.0 33552000.0 52335000.0 45630000.0 False True 43433725.408796534 49422511.2438376 37325808.203337535 1.0 1.1378833102312742 0.859373858724493 25.372312365524927 -6.772093485531735 1.5663916156163544 1.0788760119504193 0.8576807398497058 0.7384920437055769 0.05814518875198381 0.2630735909095112 1.2741368660206178 0.029253766010038283 0.06950462239562487 1.690077089208388e-07 6.772093485531735 -0.22119527210071344 TLHPDLGTDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLHPDLGTDK 10 0 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 23258200.0 1689300.0 10400000.0 11168900.0 False True 2214688.659204471 8848360.538882483 10013249.367653955 1.0 3.9953067453105873 4.521289855365391 21.078672468378784 -9.790770948709385 0.4508614987723338 2.0604552070813074e-22 4.541755657751853 0.9987781043523861 0.05421315985825793 1.0922131418397214 0.1983770892470552 1.7289583095854337 0.11751748309961155 1.6189336544602524e-10 9.790770948709385 4.541755657751853 TLHPDLGTDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLHPDLGTDK 10 0 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 25522400.0 2371900.0 7571500.0 15579000.0 False True 2296605.3328124173 10594839.434850888 11498392.540018082 1.0 4.613260834797624 5.006690690706173 21.131071522985884 -9.897928565389687 0.5422873085076501 1.159194366819562e-18 4.9814396395214615 0.9992457004522752 0.04952421418424806 1.1739987106074388 0.2492966706187043 2.1230748546325957 0.07398234175450233 1.2649443938142338e-10 9.897928565389687 4.9814396395214615 TLHPDLGTDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLHPDLGTDK 10 0 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 39588900.0 10167600.0 25040100.0 4381200.0 False True 15424992.551127935 20571498.515805736 3515253.8996518217 1.0 1.3336472252818994 0.22789339365967945 23.878766456895573 -6.825787072345936 1.3466380523395456 1.1788617938281125 0.20062069804714108 0.8971796349618326 0.14849609763735114 0.18606914764924978 0.6613770698243966 0.08661637338290384 0.19939822603078575 1.4935264823033208e-07 6.825787072345936 -0.9782410957809714 down TLHPDLGTDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLHPDLGTDK 10 0 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 20480000.0 1689300.0 9411500.0 9379200.0 False True 2313879.861615963 8995668.810331417 7164026.130687438 1.0 3.8876991669087952 3.0961098065325827 21.141882529901675 -10.543123100286339 11.296926259423016 0.9999828209196094 3.491904486720684 0.9296419056176498 0.3231650031229716 0.00013989922451910526 5.657828364429172e-06 0.3129052602885147 0.10430105626436137 2.8633662369045102e-11 10.543123100286339 2.4919216658010748 TLHPDLGTDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLHPDLGTDK 10 0 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 14949100.0 2371900.0 8459800.0 4117400.0 False True 1972339.9429863074 8414225.378261173 4978329.303293369 1.0 4.266113155687172 2.5240726483263893 20.91147679842016 -9.88402080575875 7.758346515582324 0.99999999473783 3.3950929020067813 0.7159401969451227 0.7111850590488425 6.43645020475983e-08 7.935429848796697e-09 0.6886019724419198 0.22953399081397513 1.3061083148628508e-10 9.88402080575875 2.3950929072689515 TLHPDLGTDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLHPDLGTDK 10 0 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 21771400.0 10167600.0 6234500.0 5369300.0 False True 13162158.633359553 5887544.594434044 4392142.493670392 1.0 0.4473084361338751 0.3336946937061286 23.649892778988022 -13.999999999999922 0.22237538602264237 4.370334696771051 0.27428861375442243 0.9995003839385419 0.006505351755077514 13.065314769186239 0.14937030796896655 19.361446408670837 0.061905976857159074 1.00000000000018e-14 13.999999999999922 -4.0960460830166285 TLHPDLGTDK(ub)DKEQWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLHPDLGTDKDKEQWK 16 2 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 1 132925000.0 35164000.0 35190000.0 62571000.0 True False 53346358.83274934 28910069.55927507 50203814.4241564 1.0 0.5419314493405907 0.9410916794069227 25.668886467159886 -10.205106938448575 7.8580188595328 1.0000001466075883 0.7415115643737569 0.3586238932598461 0.16295648154574233 4.183850566196332e-07 4.2486715498135147e-08 0.157782024137817 0.05259397826526802 6.235812691190501e-11 10.205106938448575 -0.2584885822338314 TLHPDLGTDK(ub)DKEQWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLHPDLGTDKDKEQWK 16 2 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 1 143756000.0 35164000.0 46416000.0 62176000.0 True False 45520491.186067 43832908.79705681 50860605.97963434 1.0 0.9629269732149391 1.1173123280181532 25.440012789252336 -6.84330191475518 1.2668821813103466 0.9802774112774897 1.1227339694615377 0.9299905449542715 0.017411261539248477 0.1649834433776101 0.5129232062550698 0.01076990746569496 0.024839467740783557 1.4344918502645018e-07 6.84330191475518 0.142456558184048 TLHPDLGTDKDK(ub)EQWKEVHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLHPDLGTDKDKEQWKEVHK 20 3 P00338;P00338-3;P00338-5;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 1 19923600.0 4886900.0 4943700.0 10093000.0 True False 7413784.580245784 4061458.1096956003 8098114.126080941 1.0 0.5478252120404817 1.0923050216024042 22.821778765203355 -6.686287407235938 1.8801289792947142 0.7155267903089064 1.0903173830083863 0.35290531275054804 0.19138566448805838 0.42467955020380055 2.907687891650957 0.08153304268685171 0.21327580515055075 2.0592666815242752e-07 6.686287407235938 0.3747905926994799 TLHPDLGTDKDKEQWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLHPDLGTDKDKEQWK 16 2 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 96792500.0 18836200.0 47390400.0 30565900.0 False True 24694440.610020246 40319937.04633234 27403233.87681634 1.0 1.632753609732376 1.10969243278574 24.557682952697473 -10.197968743068715 4.405921121925094 0.9998933631018676 1.3712230212141245 0.40176681654553015 0.21353883133095466 23607643.521059997 54642420.29980491 15054.907481478755 0.07310002613181 6.339153336072735e-11 10.197968743068715 0.37132965811225693 TLHPDLGTDKDKEQWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLHPDLGTDKDKEQWK 16 2 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 110177000.0 30945500.0 19385000.0 59846500.0 False True 29963152.041210327 27125531.591439575 44170906.29348425 1.0 0.9052963304438738 1.4741742201465668 24.8366860635431 -6.864117399241387 1.1646853548085694 0.9479350976475426 1.5039786843497398 0.9584555126977815 0.05072609188649665 0.14262428380575287 0.36530772868168315 0.03390685708755722 0.07955670983607874 1.3673591487236621e-07 6.864117399241387 0.5560435867021972 TLHPDLGTDKDKEQWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLHPDLGTDKDKEQWK 16 2 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 443786700.0 80942700.0 262435000.0 100409000.0 False True 122795993.60401487 215601423.8359863 80563117.13917185 1.0 1.7557692031162253 0.6560728471237176 26.871688250573204 -6.721751914978748 1.7529755464341426 1.4589348266204427 0.6576109392139964 0.5207999578506934 0.3179635653403955 0.35191898447992825 2.114366430173652 0.14396908700271593 0.3606785714611911 1.8977896990856406e-07 6.721751914978748 -0.8013238874064463 TLHPDLGTDKDKEQWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLHPDLGTDKDKEQWK 16 2 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 97403400.0 18836200.0 30891300.0 47675900.0 False True 25800452.169165064 29526420.222131565 36415834.33598187 1.0 1.1444148353887968 1.411441710293108 24.620893014220364 -6.961550508250193 0.41300394305309446 0.9872692020640882 1.5785455833054025 0.9998234450191132 0.0022646759132229936 0.07915186439529703 0.019118844524537975 0.0034418616626744896 0.02227354866596624 1.0925705543425734e-07 6.961550508250193 0.5912763812413143 TLHPDLGTDKDKEQWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLHPDLGTDKDKEQWK 16 2 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 85139400.0 30945500.0 38723700.0 15470200.0 False True 25732554.368094303 38515087.742047384 18704947.29387696 1.0 1.496745608349014 0.7268981938718511 24.617091338977378 -6.732496459074515 1.7142509996991553 1.2981029813822569 0.7271515418410434 0.5707830918424619 0.2087813208543463 0.33155903700747696 1.9099481362597086 0.0964737660741602 0.23870820541150245 1.8514139892445284e-07 6.732496459074515 -0.5709514395412135 TLHPDLGTDKDKEQWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLHPDLGTDKDKEQWK 16 2 P00338;P00338-3;P00338-5;P00338-2;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 235759900.0 80942700.0 77901300.0 76915900.0 False True 104781920.76915212 73566024.1742538 62917995.423780166 1.0 0.7020869977782628 0.6004661392149558 26.642814572665653 -13.999999999999998 0.1501298125553669 2.440821941339462 0.4888297152924631 0.9995658062501203 0.003532835531220656 11.958179892191845 0.1220341986179259 5.026012690708508 0.10063507106281089 1.0000000000000041e-14 13.999999999999998 -1.951992226046999 TLHSDDEGTVLDDSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLHSDDEGTVLDDSR 15 0 O00170;E9PMH2 O00170 AIP AH receptor-interacting protein 0 4837300.0 1490200.0 1589100.0 1758000.0 False True 1442894.41669424 2223635.9170470233 1297527.061130482 1.0 1.5410939922697255 0.8992529502631221 20.46053430429907 -6.683228841180878 1.8906316920625765 1.3413687324857724 0.90164577889028 0.33882383251454085 0.22916998764506463 0.4314145545754175 2.9842413564596817 0.09716933137804624 0.25520211242678903 2.0738204789700996e-07 6.683228841180878 -0.4397229535954924 TLHTCLELLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLHTCLELLR 10 0 F8W7U8;P49959-2;P49959;P49959-3;F5GXT0;F5H742;F5H256 F8W7U8 MRE11A Double-strand break repair protein MRE11A 0 7347500.0 2476700.0 2628200.0 2242600.0 False True 3246977.684396915 2236082.8046433623 2010557.2645382034 1.0 0.6886658985642786 0.6192088335561317 21.630666038727806 -13.999999999999995 0.21079899681841072 2.8064951011855648 0.5786141297223003 0.9994904742855639 0.003737613297747137 12.7655551395516 0.14551930258811072 9.554889993330345 0.04091395399556294 1.0000000000000123e-14 13.999999999999995 -2.2278809714632644 TLHTCLELLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLHTCLELLR 10 0 F8W7U8;P49959-2;P49959;P49959-3;F5GXT0;F5H742;F5H256 F8W7U8 MRE11A Double-strand break repair protein MRE11A 0 25465500.0 6616500.0 12749000.0 6100000.0 False True 10037714.230943182 10473841.341608346 4894332.326275019 1.0 1.0434488470812127 0.487594308192925 23.258927443149258 -6.888012386599922 1.034096064970171 1.0313054590351542 0.4416114447805318 0.979594303546894 0.036057158505562584 0.12076951010295783 0.23140014473321846 0.02663517406325059 0.06594245900968843 1.2941589299575052e-07 6.888012386599922 -0.5896940142546224 down TLHTCLELLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLHTCLELLR 10 0 F8W7U8;P49959-2;P49959;P49959-3;F5GXT0;F5H742;F5H256 F8W7U8 MRE11A Double-strand break repair protein MRE11A 0 9812300.0 2476700.0 2744300.0 4591300.0 False True 3392402.9203008646 2623047.751813474 3506929.5007916694 1.0 0.7732123257283489 1.0337597222916692 21.693876100250698 -6.676621592169872 1.9137955287267332 0.8560734961210521 1.032744633327288 0.3086909367378132 0.09619033951684797 0.4461219061495445 3.156083692138734 0.040373194969960995 0.10694842378006948 2.105612294880525e-07 6.676621592169872 0.17667113720623595 TLHTCLELLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLHTCLELLR 10 0 F8W7U8;P49959-2;P49959;P49959-3;F5GXT0;F5H742;F5H256 F8W7U8 MRE11A Double-strand break repair protein MRE11A 0 24543300.0 6616500.0 12458000.0 5468800.0 False True 8565189.68071358 11764701.348537864 4473534.514626611 1.0 1.373548256033219 0.5222925214020377 23.030053765241707 -6.787430729072063 1.506663913788172 1.2094727891102748 0.5138776882787992 0.7928824688247533 0.15855277910849627 0.23919450571001696 1.0727201466989855 0.08284619428478644 0.19432572826980407 1.631433105655703e-07 6.787430729072063 -0.6955951008314756 TLHTDILFGLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLHTDILFGLIK 12 0 O60231;Q5SQH5;A0A140T8Y5;A0A140T947;A0A140T9T4 O60231 DHX16 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 0 4535900.0 399900.0 2502400.0 1633600.0 False True 547753.8368911523 2391835.693669805 1247777.3250480858 1.0 4.366625174631323 2.2779892006416738 19.063168159438618 -9.201279653500142 8.99726232786908 1.0000001702102825 3.3223071876376875 0.6224080972530874 0.8526820657973492 0.0 1.708080647186762e-17 0.8256058724065696 0.2752019533680284 6.291009579525115e-10 9.201279653500142 2.3223070174274048 TLHTTASNWLHLIPQTLSHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLHTTASNWLHLIPQTLSHLK 21 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6I5 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 168515500.0 88121000.0 42125000.0 38269500.0 False True 85323647.08999678 58945732.178972885 28245569.88960923 1.0 0.6908487176690739 0.33104034875368915 26.346442298035804 -7.129418997794384 0.3017821567907953 1.0676850407420855 3.3009963011031625e-12 0.9999463974567656 0.0020013813846394505 0.07972836123860155 0.01354182992517476 0.0077484055126287475 0.03482657722749659 7.423026350116095e-08 7.129418997794384 -1.0676850407387846 down TLHTTASNWLHLIPQTLSHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLHTTASNWLHLIPQTLSHLK 21 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6I5 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 411269700.0 94988200.0 144919500.0 171362000.0 False True 144104043.96760774 119057482.96377857 137492225.58936724 1.0 0.8261911302818176 0.954117745788406 27.10253558128852 -10.341922308315183 5.095597927391041 1.0000486946368492 0.8901544380497618 0.49572992586883824 0.052225822085444955 2.890395568821242e-05 3.7328712006462277e-06 0.050589835006399235 0.016855811598235806 4.550694610253276e-11 10.341922308315183 -0.1098942565870874 TLHTTASNWLHLIPQTLSHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLHTTASNWLHLIPQTLSHLK 21 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6I5 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 150260500.0 88121000.0 42604700.0 19534800.0 False True 73276515.92221287 42375180.02472918 23619436.361289967 1.0 0.5782914142603724 0.3223329611681227 26.12684757347008 -8.721140067409381 0.18543550517992027 1.3773664258939584 9.653278210324015e-11 0.9997338961673878 0.00455778196687526 0.27299037982956126 0.05287619888829887 0.19828787122600944 0.13943231935333705 1.900465248476614e-09 8.721140067409381 -1.3773664257974256 down TLHTTASNWLHLIPQTLSHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLHTTASNWLHLIPQTLSHLK 21 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6I5 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 281635500.0 94988200.0 116518300.0 70129000.0 False True 122964097.39734866 110033954.17718239 57366241.584305406 1.0 0.8948461909301579 0.4665283834754707 26.87366190338097 -6.944457949099816 0.6166980112043952 1.0047003458514634 0.3341109432819255 0.9986914159338193 0.008346319458545599 0.08579047786193413 0.045781660667169106 0.008430889553817128 0.036204068512407386 1.1364283278949575e-07 6.944457949099816 -0.6705894025695379 down TLIEAGLPQK(ub)VAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLIEAGLPQKVAER 14 1 O43390;O43390-3;O43390-2 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 7771700.0 3484600.0 2527000.0 1760100.0 True False 3373983.2803736045 3536044.278130909 1299077.0081318321 1.0 1.0480325432256912 0.38502769580647833 21.68602139375527 -6.889478612206215 1.025426226578729 1.0360704258773918 0.3285746437895881 0.9805637581711565 0.04208344400357565 0.1195686437802536 0.2243090973514416 0.031290544931158744 0.07786550519994398 1.2897970752487646e-07 6.889478612206215 -0.7074957820878037 down TLIEAGLPQK(ub)VAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLIEAGLPQKVAER 14 1 O43390;O43390-3;O43390-2 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 5479200.0 1876200.0 2100700.0 1502300.0 True False 2569881.8423985485 2007884.127914065 1147487.6808397025 1.0 0.7813137922481471 0.44651378982028117 21.293270598274685 -6.964915570613533 0.35950035898363286 1.0290148829050672 0.18734843344327107 0.999911391506467 0.0021425438004904532 0.07798964072264071 0.014961174784368148 0.004496420606749003 0.02860470289536985 1.0841376562347693e-07 6.964915570613533 -0.841666449461796 down TLIEAGLPQK(ub)VAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLIEAGLPQKVAER 14 1 O43390;O43390-3;O43390-2 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 6256960.0 3484600.0 1842600.0 929760.0 True False 2897599.293954252 1832673.5480725346 1124168.5172754752 1.0 0.632479981582115 0.38796548564220623 21.466426669189545 -8.292391669203964 0.1691450454342007 1.3479515636855532 4.09861856820506e-10 0.9998765802252317 0.0027944472335611576 0.09159312646061425 0.03669948966613669 0.12705413313670616 0.127280000662402 5.100448077321774e-09 8.292391669203964 -1.3479515632756913 down TLIEAGLPQK(ub)VAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLIEAGLPQKVAER 14 1 O43390;O43390-3;O43390-2 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 11939200.0 5311500.0 3843600.0 2784100.0 True False 6875841.455317802 3629700.281204058 2277422.3672783705 1.0 0.5278917940140743 0.3312208959555057 22.713104848540407 -13.999999997659648 0.12009498135949918 3.2499818221907284 0.017723696465547133 0.9996924760559931 0.004921407122840955 11.963377741514192 0.10666536118064598 6.423546433453621 0.27819471911247784 1.0000000053888595e-14 13.999999997659648 -3.2322581257251812 TLIEFLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLIEFLLR 8 0 P28838-2;P28838 P28838-2 LAP3 Cytosol aminopeptidase 0 6279400.0 2161300.0 2500300.0 1617800.0 False True 2833485.2300589764 2127264.986093066 1450405.5750334004 1.0 0.7507591582006549 0.5118804077913657 21.434146251540025 -6.9716423736474376 0.21538286584070412 1.1167893499951764 0.13914084059672038 0.999992513908131 0.0005452384335854747 0.07577335094520647 0.007091575346368915 0.00685687404352913 0.024454429904115935 1.0674747876466256e-07 6.9716423736474376 -0.977648509398456 TLIEFLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLIEFLLR 8 0 P28838-2;P28838 P28838-2 LAP3 Cytosol aminopeptidase 0 22606400.0 12009000.0 5553100.0 5044300.0 False True 11627780.86839426 7770481.7890339475 3723046.504243739 1.0 0.6682686814433418 0.320185471878253 23.471072452712686 -7.276865801286164 0.28867376153757723 1.0837548680231577 3.4283348895395255e-16 0.9998987977556562 0.002792227719330426 0.10143656437579744 0.018681042074255003 0.012906317019781286 0.046466069368619176 5.2860856868103964e-08 7.276865801286164 -1.0837548680231572 down TLIEFLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLIEFLLR 8 0 P28838-2;P28838 P28838-2 LAP3 Cytosol aminopeptidase 0 74013000.0 21258000.0 32675000.0 20080000.0 False True 32249940.167972542 26843890.959059764 16111179.198623342 1.0 0.8323702561692957 0.4995723748543067 24.942793148175355 -6.960189014120745 0.43276601065374565 1.0128379000836867 0.3062841199090128 0.9997771338694497 0.0031047896002035207 0.07963373703049678 0.020882733401276395 0.0043516152867327795 0.027615231352084414 1.0960010895310122e-07 6.960189014120745 -0.706553780174674 down TLIEFLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLIEFLLR 8 0 P28838-2;P28838 P28838-2 LAP3 Cytosol aminopeptidase 0 14733500.0 2161300.0 5124600.0 7447600.0 False True 2960391.016936356 4898178.227213986 5688630.268136697 1.0 1.6545713722246744 1.9215807086267056 21.497356313062916 -10.6327582878961 0.18631869687803898 2.4718666189328884e-17 2.1735864319291407 0.9994610034734984 0.008988529895091713 2.4717970599872254 0.09843772896276713 1.2989015162250805 0.18192289171194218 2.3293873470355367e-11 10.6327582878961 2.1735864319291407 TLIEFLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLIEFLLR 8 0 P28838-2;P28838 P28838-2 LAP3 Cytosol aminopeptidase 0 19985600.0 12009000.0 4852100.0 3124500.0 False True 9986015.588904502 4825960.774233552 3777818.5039442703 1.0 0.48327190472200887 0.378310895903449 23.251477728146963 -13.999999999999938 0.22406379595499076 4.174875756894142 0.324307472068135 0.9995022872242885 0.006062093781074673 13.113389574150624 0.14992325521715577 18.461513446802847 0.056569966943309825 1.0000000000001431e-14 13.999999999999938 -3.850568284826007 TLIEFLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLIEFLLR 8 0 P28838-2;P28838 P28838-2 LAP3 Cytosol aminopeptidase 0 67412000.0 21258000.0 23201000.0 22953000.0 False True 27518900.057826564 21909843.954681892 18775789.51766832 1.0 0.7961744077213065 0.6822870637348879 24.713919470267804 -13.999999999999618 0.06866011188709416 2.192943575984784 0.25731686662805436 0.9999288872406782 0.0011082847386615258 12.37439090738908 0.07026513842422343 2.3844335550279405 0.3922864770864407 1.0000000000008794e-14 13.999999999999618 -1.9356267093567296 TLIENGEK(ub)ITSLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLIENGEKITSLHR 14 1 P37198;M0QXN5 P37198 NUP62 Nuclear pore glycoprotein p62 1 14894800.0 1783000.0 2359300.0 10752500.0 True False 1726399.6409648573 3301380.7935869615 7936097.681914389 1.0 1.9122923309587068 4.596906471481326 20.719335039228987 -6.951883296136963 0.5377707183483373 0.9598855316522477 5.672816328329999 0.9993409113662335 0.03919440399224957 0.08273820371070532 0.03289994943165923 0.04324259636256642 0.2222467277673222 1.1171634122434389e-07 6.951883296136963 4.712930796677751 TLIENGEK(ub)ITSLHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLIENGEKITSLHR 14 1 P37198;M0QXN5 P37198 NUP62 Nuclear pore glycoprotein p62 1 62221960.0 5555260.0 24936700.0 31730000.0 True False 8427735.563906811 20486551.05367364 25458551.592246935 1.0 2.4308488203415783 3.0208056955746745 23.00671361691255 -9.544191639988199 0.25458152025624625 7.515913295260261e-24 3.366265139289083 0.9990555122564037 0.026075461161407958 0.9459506917625204 0.10313849342877071 1.0099983639381007 0.2531070769484103 2.85632986005229e-10 9.544191639988199 3.366265139289083 TLIENGEK(ub)ITSLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLIENGEKITSLHR 14 1 P37198;M0QXN5 P37198 NUP62 Nuclear pore glycoprotein p62 1 10835100.0 1783000.0 2908500.0 6143600.0 True False 1482643.5002928416 2892831.333207955 7428198.355203065 1.0 1.9511307557323003 5.0101041509546285 20.499740314663264 -6.949876925178029 0.560192600897397 0.9600330424475789 6.147443577421187 0.99919159381336 0.04864356262141841 0.0835351922911923 0.03616710346771696 0.05213100025783255 0.2542942675718285 1.1223364684516004e-07 6.949876925178029 5.187410534973608 TLIENGEK(ub)ITSLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLIENGEKITSLHR 14 1 P37198;M0QXN5 P37198 NUP62 Nuclear pore glycoprotein p62 1 72914260.0 5555260.0 29224000.0 38135000.0 True False 7191393.580545747 27597658.710039366 31194821.29814329 1.0 3.837595370207093 4.337799196880551 22.777839939005 -9.822766521509642 0.4440880383445143 2.616223384994967e-19 4.361239234624067 0.9988033351420909 0.05084488409547184 1.125974931460199 0.1958855364202218 1.7245375069944906 0.11351613359790992 1.503950278617589e-10 9.822766521509642 4.361239234624067 TLINAEDPPMVVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLINAEDPPMVVVR 14 0 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 3767910.0 793110.0 1394100.0 1580700.0 False True 1039774.8904881658 1186105.7141592386 1417144.3271450715 1.0 1.1407331769690763 1.362933785100094 19.987839790450817 -6.964391957945421 0.36834642856263744 0.9825890495192692 1.5287922326864243 0.999900045844997 0.0014937081653137974 0.07816798020784817 0.015591722460328764 0.002936341074333972 0.01888825748113741 1.085445548874952e-07 6.964391957945421 0.5462031831671551 TLINAEDPPMVVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLINAEDPPMVVVR 14 0 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 0 5688510.0 793110.0 2358900.0 2536500.0 False True 1086344.1999918527 2254675.9981608447 1937430.9408572875 1.0 2.0754711059144553 1.7834411422013554 20.05104985197371 -10.139100979294964 4.613696168448497 0.9999155979896562 1.92945612390282 0.9310652171075994 0.11922073380547511 83309212.10718143 17.015394233620217 87751.09794451133 0.04081242821098065 7.259371476822548e-11 10.139100979294964 0.9295405259131638 TLIPSPPPRPK(ub)NPVFDDEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLIPSPPPRPKNPVFDDEEK 20 2 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 12643600.0 3709700.0 4636600.0 4297300.0 True False 4863452.6247859085 3944837.3533252464 3852656.6186123374 1.0 0.8111186964628652 0.7921649321672858 22.21354943380781 -13.999999999963041 0.3249758612866118 2.9949996636766874 0.7886075112719545 0.9997043165921163 0.0016133793119603931 18.408010658118044 0.182037487099981 25.034648602304507 0.006190237167241069 1.0000000000851009e-14 13.999999999963041 -2.206392152404733 TLIPSPPPRPK(ub)NPVFDDEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLIPSPPPRPKNPVFDDEEK 20 2 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 32038300.0 11358000.0 12066000.0 8614300.0 True False 17230916.381025113 9912728.027911708 6911679.82921818 1.0 0.5752873386831429 0.40112085024273014 24.038496093760745 -13.999999999999998 0.12253476473619226 3.021063154107426 0.1324026044448739 0.9996806002452517 0.004495141484293218 11.954739715940246 0.10804973495566546 5.864872702083993 0.2385199556276678 1.0000000000000041e-14 13.999999999999998 -2.888660549662552 TLIPSPPPRPK(ub)NPVFDDEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLIPSPPPRPKNPVFDDEEK 20 2 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 11215700.0 3709700.0 4232700.0 3273300.0 True False 5081276.340872993 4045685.3183328668 2500213.9557296126 1.0 0.7961947052141224 0.4920444762309584 22.2767594953307 -6.965342020590154 0.352133744995651 1.0286801824885403 0.24926217495017883 0.9999200216919812 0.0018665540839177513 0.07784509753405032 0.014451831362133712 0.0041528321005628 0.026105975075440005 1.083073623459993e-07 6.965342020590154 -0.7794180075383614 down TLIPSPPPRPK(ub)NPVFDDEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLIPSPPPRPKNPVFDDEEK 20 2 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 16047400.0 6366200.0 7229200.0 2452000.0 True False 5293777.37047913 7190254.8647161545 2964701.8632329465 1.0 1.3582465527947538 0.560035236798146 22.335866092971358 -6.784690402364439 1.5174886087730903 1.2016133730748213 0.5527447763445626 0.783666658968241 0.1518312964048839 0.24335573222979429 1.1070842863466506 0.07878089774467743 0.18518310779568833 1.6417597254360648e-07 6.784690402364439 -0.6488685967302587 TLIPSPPPRPK(ub)NPVFDDEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLIPSPPPRPKNPVFDDEEK 20 2 Q9NZ52-2;Q9NZ52;J3KSS7;Q9NZ52-3;Q9NZ52-4;J3KSG3 Q9NZ52-2 GGA3 ADP-ribosylation factor-binding protein GGA3 1 38282000.0 11358000.0 21129000.0 5795000.0 True False 14703154.899651607 19953152.57611628 4740369.461721256 1.0 1.3570660659086895 0.32240491881328 23.809622415853195 -6.813487858455782 1.3995983670145327 1.1938039149545903 0.302774999560592 0.8688288535979425 0.15541017964959505 0.20205431211118036 0.7793613221124851 0.0872913207057441 0.20164417326331371 1.5364277465475353e-07 6.813487858455782 -0.8910289153939983 down TLIQNCGASTIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLIQNCGASTIR 12 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 53771000.0 10103000.0 18828000.0 24840000.0 False True 13245130.837591175 16018935.790969184 22269795.08210511 1.0 1.2094207288240322 1.6813571232456928 23.65895875916948 -6.957645639963049 0.4674378590966359 0.9872194200583816 1.922822136483203 0.9996726537304258 0.005155727059009286 0.08055317291603058 0.024322264626969056 0.006494312226173177 0.03895909588011793 1.1024384708673333e-07 6.957645639963049 0.9356027164248214 TLIQNCGASTIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLIQNCGASTIR 12 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 19477700.0 9976700.0 4259500.0 5241500.0 False True 9659995.119469471 5960340.5629990585 3868593.908370546 1.0 0.6170127923756551 0.40047576220545855 23.20359102949092 -9.702395724810316 0.1338423506156286 1.6699167483789428 1.3537262167021154e-09 0.9998399002065226 0.003136423533904264 1.1858144468312222 0.056529019984204634 0.49678899961317363 0.2096477468430833 1.9842860316764568e-10 9.702395724810316 -1.6699167470252165 TLIQNCGASTIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLIQNCGASTIR 12 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 165187000.0 29931000.0 113100000.0 22156000.0 False True 45407515.249204285 92916421.34566678 17776856.888680223 1.0 2.0462784813422497 0.3914959184865713 25.43642775722286 -6.7358485106026995 1.701978230301406 1.6255189320790322 0.39139973093892116 0.5860937653300786 0.43966708338558447 0.32539793807594136 1.8491129066481162 0.20450443971942536 0.5041246511407868 1.8371790713043133e-07 6.7358485106026995 -1.234119201140111 TLIQNCGASTIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLIQNCGASTIR 12 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 50091000.0 10103000.0 14697000.0 25291000.0 False True 13838352.123309107 14047637.943520257 19317786.68449504 1.0 1.0151236085298503 1.395960047291791 23.72216882069237 -6.915270944913944 0.8590731216761311 0.990081699963716 1.45115577020973 0.9927631193076397 0.015584521241076768 0.10103481827937259 0.1206260179237745 0.013101594917495435 0.0376338060127442 1.2154274907938746e-07 6.915270944913944 0.461074070246014 TLIQNCGASTIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLIQNCGASTIR 12 0 P49368;B4DUR8;P49368-2 P49368 CCT3 T-complex protein 1 subunit gamma 0 84690000.0 29931000.0 26716000.0 28043000.0 False True 38746269.52821553 25229231.114748575 22939461.745478716 1.0 0.6511396173604875 0.5920431056923792 25.207554079315308 -13.999999999999998 0.24980478985107515 3.423776683817169 0.5682371679562328 0.9995423217384223 0.0038509743055467715 13.990232858998382 0.15815546063949615 17.013440755958786 0.027302311959435707 1.0000000000000041e-14 13.999999999999998 -2.855539515860936 TLITFAGMIPYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLITFAGMIPYR 12 0 Q8N1F7;Q8N1F7-2;H3BV15 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 0 16687900.0 4731400.0 8061300.0 3895200.0 False True 6202911.218942771 6858585.462701292 3492162.069396779 1.0 1.1057042766880476 0.5629875950396056 22.56451404536916 -6.856176158793351 1.2048930115375425 1.0568640543917407 0.5385607663467348 0.948823991200579 0.05314429896363327 0.15079095761793385 0.4181716875066449 0.034450754549272426 0.08010377720798403 1.3925918244220918e-07 6.856176158793351 -0.5183032880450059 TLITFAGMIPYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLITFAGMIPYR 12 0 Q8N1F7;Q8N1F7-2;H3BV15 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 0 29533300.0 8518300.0 10282000.0 10733000.0 False True 12922883.871146876 8447096.766367322 8611617.845558984 1.0 0.6536541572757831 0.6663851452527773 23.623424722040106 -9.978521959420586 5.761783062024137 1.0000004425057594 0.6600196512713984 0.9989494375061382 0.005197404078076624 2.954133971655917e-08 5.244951822221417e-09 0.00503237138302358 0.0016774549530778316 1.0506983266063802e-10 9.978521959420586 -0.339980791234361 TLITFAGMIPYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLITFAGMIPYR 12 0 Q8N1F7;Q8N1F7-2;H3BV15 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 0 10624500.0 1070200.0 4141900.0 5412400.0 False True 889918.7178987085 4119586.7625972247 6544107.815889885 1.0 4.6291719454159415 7.353601721449286 19.763314045752267 -7.9584506522926395 0.29334484556684975 2.940984651511056e-22 9.213071099732334 0.999215015757231 0.07291848062544254 0.1095743920766902 0.0570251974938098 0.48268631263370165 0.7721203655227303 1.10039687331282e-08 7.9584506522926395 9.213071099732334 TLK(ub)ATASSSAQEMEQQLAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLKATASSSAQEMEQQLAER 20 1 J3KQ34;Q9H9Q2;J3QT73;A0A087X1P5;Q9H9Q2-2 J3KQ34 COPS7B COP9 signalosome complex subunit 7b 1 22419300.0 7844900.0 9377700.0 5196700.0 True False 10284739.870119676 7978583.713988297 4658995.334266334 1.0 0.7757691312318487 0.45300079468243476 23.294001968737064 -6.965932983696424 0.34166161321180605 1.0343418135570053 0.1836745610047195 0.9999311050751649 0.0018635406779899718 0.07764577176019018 0.013751476165853807 0.004533551989794715 0.02790327975100805 1.0816008410490647e-07 6.965932983696424 -0.8506672525522858 down TLK(ub)ATASSSAQEMEQQLAER ddPTM_RPMI8226_Bortezomib_2h_R1 2 TLKATASSSAQEMEQQLAER 20 1 J3KQ34;Q9H9Q2;J3QT73;A0A087X1P5;Q9H9Q2-2 J3KQ34 COPS7B COP9 signalosome complex subunit 7b 1 38479000.0 12274200.0 15424800.0 10780000.0 True False 11884562.23955739 21584003.079269342 7956394.606932075 1.0 1.8161378302540814 0.6694730900940943 23.502585427697944 -6.7155763068002665 1.7753738961074788 1.4988556693147865 0.6717025490738221 0.49155052763433726 0.34363180173656116 0.363958196374573 2.239491030118429 0.15383766119826411 0.38819337199090026 1.9249687927617826e-07 6.7155763068002665 -0.8271531202409644 TLK(ub)ATASSSAQEMEQQLAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLKATASSSAQEMEQQLAER 20 1 J3KQ34;Q9H9Q2;J3QT73;A0A087X1P5;Q9H9Q2-2 J3KQ34 COPS7B COP9 signalosome complex subunit 7b 1 83225000.0 28688000.0 31491000.0 23046000.0 True False 43521793.37373199 25871185.009693954 18490947.998579375 1.0 0.5944420715279799 0.4248664074982666 25.375234670204257 -13.99999999999999 0.11951646253097634 2.9336603047148158 0.15244166384679628 0.9996953177000709 0.004211845952806213 11.965625432918342 0.10633319787754099 5.499148864497332 0.24173912069941733 1.0000000000000246e-14 13.99999999999999 -2.7812186408680195 TLK(ub)ATASSSAQEMEQQLAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLKATASSSAQEMEQQLAER 20 1 J3KQ34;Q9H9Q2;J3QT73;A0A087X1P5;Q9H9Q2-2 J3KQ34 COPS7B COP9 signalosome complex subunit 7b 1 25206700.0 7844900.0 7144800.0 10217000.0 True False 10745371.530451125 6829119.111305952 7803955.02572006 1.0 0.6355405294226475 0.7262620006767161 23.357212030259955 -9.84106314202613 6.210677304950463 1.0000000202368184 0.6809012650495494 0.9428428469330709 0.037036885548319305 1.0371262131967988e-08 1.892883894463797e-09 0.035860812368264265 0.011953603410265471 1.4419056977764093e-10 9.84106314202613 -0.31909875518726905 TLK(ub)ATASSSAQEMEQQLAER ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TLKATASSSAQEMEQQLAER 20 1 J3KQ34;Q9H9Q2;J3QT73;A0A087X1P5;Q9H9Q2-2 J3KQ34 COPS7B COP9 signalosome complex subunit 7b 1 45689800.0 12274200.0 23589900.0 9825700.0 True False 10206541.139256518 23462816.52647149 11880208.441096228 1.0 2.298801935577228 1.1639798712418286 23.28299070313222 -6.613533119594571 2.1407238414033327 1.8656541709735392 1.1681454230541575 0.06154363476399005 0.5594509009575578 0.6028995237547992 5.2407500626351515 0.21542955740956612 0.620750036598228 2.434820111822803e-07 6.613533119594571 -0.6975087479193818 TLK(ub)ATASSSAQEMEQQLAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLKATASSSAQEMEQQLAER 20 1 J3KQ34;Q9H9Q2;J3QT73;A0A087X1P5;Q9H9Q2-2 J3KQ34 COPS7B COP9 signalosome complex subunit 7b 1 112701000.0 28688000.0 71893000.0 12120000.0 True False 37137181.52502244 67892091.35097389 9914284.361701751 1.0 1.8281433475297333 0.2669638339415086 25.146360992296707 -6.7625812255679865 1.6025072566751026 1.479499664635148 0.2604787740073349 0.7014434983482181 0.3484648273596983 0.2786371734426489 1.4107871555040998 0.17151296982552477 0.41116975281520435 1.7275028575367839e-07 6.7625812255679865 -1.219020890627813 TLK(ub)EITEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLKEITEGK 9 1 Q9BZX2;A0A2R8Y653 Q9BZX2 UCK2 Uridine-cytidine kinase 2 1 3925100.0 1278900.0 1598600.0 1047600.0 True False 1238302.0195344656 2236929.3165888684 773202.1326736588 1.0 1.806448896392685 0.6244051293434383 20.23993179740172 -6.723008458370275 1.7483074855644138 1.4890418849051386 0.625903747919816 0.5267715941935924 0.3392369727294907 0.3494975535625263 2.089270811113978 0.15396752362137564 0.38518178545780296 1.892306763497573e-07 6.723008458370275 -0.8631381369853226 TLK(ub)EITEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLKEITEGK 9 1 Q9BZX2;A0A2R8Y653 Q9BZX2 UCK2 Uridine-cytidine kinase 2 1 4441150.0 1278900.0 2502800.0 659450.0 True False 1063462.0148763387 2489316.919633099 797337.9460477022 1.0 2.3407671217317163 0.7497568647437005 20.020337072835996 -6.683267292445821 1.8901678085967653 1.8458141177727432 0.7556350731757093 0.3391801212367591 0.56784691996666 0.43131114574413043 2.9820061960116035 0.24080859601449459 0.6324961927487673 2.0736368766125256e-07 6.683267292445821 -1.0901790445970339 TLK(ub)EITEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLKEITEGK 9 1 Q9BZX2;A0A2R8Y653 Q9BZX2 UCK2 Uridine-cytidine kinase 2 1 6833200.0 2592200.0 1453900.0 2787100.0 True False 3355653.9999011154 1372989.1869191844 2279876.398060971 1.0 0.40915695925731427 0.679413431220309 21.678162537080258 -10.426065410683522 6.085353700049473 1.0001465879127496 0.5442851952388275 0.7912825410652762 0.11033174266568782 0.00021949480270725964 2.0701295351725126e-05 0.10686215947341822 0.03560941682518755 3.749165304402335e-11 10.426065410683522 -0.4558613926739221 TLK(ub)GHTDSVQDISFDHSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLKGHTDSVQDISFDHSGK 19 1 P43034 P43034 PAFAH1B1 Platelet-activating factor acetylhydrolase IB subunit alpha 1 12433300.0 1437000.0 2429000.0 8567300.0 True False 1860224.827504785 2293824.014737398 7008139.307921397 1.0 1.2330896678839738 3.767361452390555 20.82704556588567 -6.924867524815168 0.7877840703078515 0.9532680642983512 4.225584649502393 0.9954297276090701 0.0847227519638545 0.09539161412849088 0.09138808153663724 0.07494731037021662 0.23610834687885263 1.188864817971132e-07 6.924867524815168 3.2723165852040417 up TLK(ub)LSVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLKLSVQR 8 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 14149600.0 2405900.0 5003800.0 6739900.0 True False 3649926.194850175 4110832.7951321607 5407755.810796885 1.0 1.126278334321471 1.4816068934289413 21.799435860878422 -6.952881277107106 0.5262627313197408 0.9942412648438731 1.629671684286073 0.9994084258614213 0.004959133518089558 0.0823489992586867 0.03133075033743249 0.005563663410665163 0.02937020890539648 1.1145991894417705e-07 6.952881277107106 0.6354304194421999 TLK(ub)LSVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLKLSVQR 8 1 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 10106100.0 2405900.0 3923700.0 3776500.0 True False 3114484.977379096 3705342.645790495 3089215.7501622676 1.0 1.1897128008973792 0.9918865470855174 21.57056218297087 -6.655677989772944 1.9881414067279168 1.1225479063972048 0.9927146916800768 0.2174101441734757 0.08085961611016135 0.49478984581398555 3.7549096711241536 0.03291083740475455 0.08960494512973348 2.209642478345733e-07 6.655677989772944 -0.12983321471712805 TLK(ub)LSYVSTASGFEDLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLKLSYVSTASGFEDLLK 18 1 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 33300200.0 4039200.0 11528000.0 17733000.0 True False 6127761.705074537 9470738.3313249 14228064.777349992 1.0 1.5455461206139869 2.321902427368775 22.546928764499626 -6.96611725020476 0.33832900568762003 0.9141462668577514 2.9790375825674125 0.9999343582324403 0.004394496278462309 0.0775838439617023 0.013534264630046741 0.011016252693442283 0.06727991436994855 1.0811420267107563e-07 6.96611725020476 2.0648913157096613 TLK(ub)LSYVSTASGFEDLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLKLSYVSTASGFEDLLK 18 1 P59045;P59045-3;K7EQV0;K7EMN8 P59045 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 18954500.0 4039200.0 8068500.0 6846800.0 True False 5228824.024535369 7619480.882218469 5600752.654100625 1.0 1.4572073656457645 1.0711304545381608 22.318055086592075 -10.238239153049168 5.952168866461174 0.9999922775962068 1.2641689100919642 0.3843290144552297 0.15761523894725318 1.615228822286966e-05 2.06743390457647e-06 0.15261475901461904 0.05087009962926708 5.7777779474728257e-11 10.238239153049168 0.2641766324957574 TLK(ub)LTTPTYGDLNHLVSATMSGVTTCLR ddPTM_RPMI8226_Bortezomib_8h_R1 2 TLKLTTPTYGDLNHLVSATMSGVTTCLR 28 1 P04350;M0R2D3;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P04350;P07437;P68371;Q13885;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 1488773200.0 357203600.0 181497000.0 950072600.0 True False 541903976.2811356 149107442.30746663 762290334.1783864 1.0 0.2751547300514932 1.4066889477535707 29.013461992198167 -6.733685876943707 1.7096909135009275 0.5655914769369664 1.4064937487321745 0.5762936700182342 0.30463012508818005 0.32938001825191665 1.8877868977424896 0.14110204973876192 0.34869696450960846 1.8463503924619036e-07 6.733685876943707 0.840902271795208 TLK(ub)LTTPTYGDLNHLVSATMSGVTTCLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TLKLTTPTYGDLNHLVSATMSGVTTCLR 28 1 P04350;M0R2D3;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P04350;P07437;P68371;Q13885;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 162701400.0 97243500.0 32074900.0 33383000.0 True False 80862278.86748561 31902106.147330858 40363230.954447605 1.0 0.39452395596729295 0.4991601958262086 26.26896352654601 -10.10321463811636 5.495248338712224 1.0000065281581068 0.4468420758972745 0.9738647949984156 0.04271756604359433 3.4166262683076072e-06 5.575437341400646e-07 0.04136159331439187 0.013787035156355692 7.884703415036851e-11 10.10321463811636 -0.5531644522608323 TLK(ub)LTTPTYGDLNHLVSATMSGVTTCLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TLKLTTPTYGDLNHLVSATMSGVTTCLR 28 1 P04350;M0R2D3;P07437;Q5JP53;Q5ST81;P68371;Q13885;Q9BVA1 P04350;P07437;P68371;Q13885;Q9BVA1 TUBB4A;TUBB;TUBB4B;TUBB2A;TUBB2B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain;Tubulin beta-2A chain;Tubulin beta-2B chain 1 998851600.0 357203600.0 202943000.0 438705000.0 True False 462407101.7356215 191649043.64876568 358865191.49342984 1.0 0.41445955939997625 0.7760806227811978 28.784588314290616 -10.337662760053163 6.612577735274463 1.0000168814137085 0.5952700910906187 0.6254926668846121 0.14763118092110802 3.674330788024044e-05 3.680166326046757e-06 0.14294922882299377 0.04764775875736543 4.595547294465715e-11 10.337662760053163 -0.4047467903230898 TLLAILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLLAILR 7 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 16053600.0 4238700.0 3909000.0 7905900.0 False True 5556976.747629192 3325792.4371626573 7087873.306747779 1.0 0.5984895363439412 1.2754909060527784 22.405868772875085 -6.746024950131173 1.6644170579971271 0.762781704480742 1.276448357676507 0.6317078763049191 0.16869560885157356 0.30705100362059656 1.6722716473383816 0.08010662057865574 0.19530639213275272 1.794630522706103e-07 6.746024950131173 0.5136666531957651 TLLAILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLLAILR 7 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 10118700.0 4084100.0 3231100.0 2803500.0 False True 3954452.4810233153 4521295.079963906 2069179.246802788 1.0 1.143342877847379 0.5232530310409331 21.915046527589002 -6.8458546761877965 1.254863064641229 1.0763045336212584 0.5003689677645919 0.9340601937869754 0.06806597314304176 0.16207852805172193 0.49321438166624304 0.04248468577911291 0.09809022550104186 1.4260847108697553e-07 6.8458546761877965 -0.5759355658566665 TLLAILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLLAILR 7 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 20913100.0 4625400.0 7264600.0 9023100.0 False True 7017069.9620349975 5968175.371421128 7239680.330034784 1.0 0.8505224265557011 1.0317241197827858 22.742437315856773 -6.687591829819397 1.8747286715688596 0.9060741270307053 1.0310831595811736 0.35915306905669875 0.06325025747062639 0.4219420767607694 2.8732177899344435 0.027007637126743235 0.07055033248064498 2.0530908627620646e-07 6.687591829819397 0.12500903255046825 TLLAILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLLAILR 7 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 16469000.0 4238700.0 4656700.0 7573600.0 False True 5805861.93656046 4450951.596352373 5784871.663188162 1.0 0.7666306303847849 0.9963846413156815 22.469078834397976 -10.803860506297575 9.121506064946425 1.00192576273797 0.881507635860557 0.26179895830517974 0.09379668218975425 0.003726973331498859 8.014088287247106e-05 0.09214474140976887 0.030272749004202334 1.570867279786379e-11 10.803860506297575 -0.12041812687741305 TLLAILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLLAILR 7 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 9916800.0 4084100.0 3000500.0 2832200.0 False True 3396110.1063073426 2984335.7109473776 3424399.9253867688 1.0 0.878751164576435 1.0083300653376595 21.69545180302328 -11.149499451980361 9.759685090767144 2.624814237965123 0.9435406149570472 0.20199775721129754 0.052900364715956445 0.04384345084533337 0.0006715978262962352 0.001200743539978002 0.017073519296099817 7.0876220081060085e-12 11.149499451980361 -1.6812736230080758 TLLAILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLLAILR 7 0 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 16744600.0 4625400.0 5615000.0 6504200.0 False True 5987671.480264879 5302520.31401831 5320502.338727766 1.0 0.8855730197448543 0.8885761946466042 22.513563637949222 -10.487481653125995 8.633176105428417 1.000004247471408 0.8870746071957315 0.9994698257717751 0.0012260410196033968 1.0023670430305274e-07 5.950718822286025e-09 0.0011871537535663949 0.0003957030375575965 3.254755329991642e-11 10.487481653125995 -0.11292964027567642 TLLAK(ub)AIANECQANFISIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLLAKAIANECQANFISIK 19 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 10333000.0 4818100.0 2020300.0 3494600.0 True False 4665152.052794597 2827016.32572532 2579259.424247203 1.0 0.6059858915063301 0.5528778901648301 22.153492673388936 -13.999999999999998 0.28241929500269514 4.254384051954664 0.5372676546762228 0.9996105430187805 0.003935871398384022 15.530483034500312 0.1683825731400893 29.234237969848643 0.020769476104050062 1.0000000000000041e-14 13.999999999999998 -3.7171163972784407 TLLAK(ub)NLPYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLLAKNLPYK 10 1 P19338 P19338 NCL Nucleolin 1 11461230.0 5232300.0 5236100.0 992830.0 True False 6859595.969665284 4454894.2901579365 890101.475497843 1.0 0.6494397497838804 0.1297600440950279 22.70969217345898 -7.455432257744205 0.5017392322460913 1.0131585934519978 2.2616430656982504e-16 0.9974031329252651 0.018218172677331963 0.11367659562109794 0.06548207949495946 0.020361402851666627 0.06634454871204166 3.50402940698603e-08 7.455432257744205 -1.0131585934519975 down TLLAK(ub)NLPYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLLAKNLPYK 10 1 P19338 P19338 NCL Nucleolin 1 16922400.0 5095500.0 6804600.0 5022300.0 True False 4933746.141635681 9521712.265520213 3706808.964229591 1.0 1.929915320362123 0.7513173272025455 22.234252055204347 -6.696359795322883 1.8436045805765597 1.5794947873791703 0.7550303209395314 0.40034249321000825 0.3927982487765145 0.403193436195579 2.6615794799893076 0.17013153148160148 0.43955033513220476 2.012056652049186e-07 6.696359795322883 -0.8244644664396389 TLLAK(ub)NLPYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLLAKNLPYK 10 1 P19338 P19338 NCL Nucleolin 1 37794000.0 9363300.0 6815400.0 21615300.0 True False 14204810.64892168 5599138.621036749 17343026.48067746 1.0 0.3941719998542742 1.220926269931941 23.759876264645545 -6.710297439977447 1.794218015776026 0.6276637200696895 1.2189953974281658 0.4664953873825848 0.2552804311748543 0.37447078676567985 2.350124361336627 0.11321894410739157 0.2875177286918308 1.948509645709761e-07 6.710297439977447 0.5913316773584762 TLLAK(ub)NLPYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLLAKNLPYK 10 1 P19338 P19338 NCL Nucleolin 1 16895500.0 5232300.0 5202600.0 6460600.0 True False 7166822.7075908445 4972731.929302473 4934739.3402336305 1.0 0.6938544641317178 0.6885532880570534 22.77290223498187 TLLAK(ub)NLPYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLLAKNLPYK 10 1 P19338 P19338 NCL Nucleolin 1 19743100.0 5095500.0 9165800.0 5481800.0 True False 4237134.018924377 9116422.016131153 6628019.035020538 1.0 2.151553851120672 1.5642693871418072 22.014657330638624 -10.07609240716532 5.462088942787409 0.9999922913717642 1.8579116191316951 0.7399417122733367 0.23975787843695937 2.2507122856317862e-05 3.8062922412502703e-06 0.23214664780421448 0.07738152252546515 8.392813891186639e-11 10.07609240716532 0.857919327759931 TLLAK(ub)NLPYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLLAKNLPYK 10 1 P19338 P19338 NCL Nucleolin 1 38130200.0 9363300.0 11306400.0 17460500.0 True False 12120976.4282363 10677188.900875624 14282868.159859188 1.0 0.8808852128449557 1.1783595360012973 23.531002586737994 -6.798025041322438 1.4638698303575317 0.934113448046106 1.182272798392084 0.8263520296462307 0.05094023025021431 0.2235885703083961 0.9461009886758697 0.027377876362551613 0.06375159459910154 1.5921169232997315e-07 6.798025041322438 0.24815935034597802 TLLAVTRPFISSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLLAVTRPFISSK 13 1 J3KN59;Q12982;Q12982-2;H7C096 J3KN59 BNIP2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 0 5928400.0 2214000.0 2047000.0 1667400.0 False True 2902575.4404065018 1741595.5791435048 1494873.442830199 1.0 0.6000173345708447 0.5150162238749061 21.468902133774513 -13.999999999999998 0.21767311949051527 3.3893389621749397 0.46852265423714956 0.9994956707365281 0.0047487094992259985 12.937332614171895 0.14781952023090472 13.271128748050646 0.04777415457314051 1.0000000000000041e-14 13.999999999999998 -2.9208163079377902 TLLAVTRPFISSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLLAVTRPFISSK 13 1 J3KN59;Q12982;Q12982-2;H7C096 J3KN59 BNIP2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 0 8295200.0 2796400.0 1760500.0 3738300.0 False True 2707629.812671969 2463476.830886215 2759127.083403912 1.0 0.90982778345729 1.0190193173715736 21.368599076357633 -6.68732059680014 1.8755116798231635 0.9433289149491647 1.018634970153494 0.3581525704191897 0.03815708882145332 0.42242670709404584 2.8786566966084015 0.0162869271096235 0.0425627592766478 2.054373494673554e-07 6.68732059680014 0.07530605520432931 TLLAVTRPFISSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLLAVTRPFISSK 13 1 J3KN59;Q12982;Q12982-2;H7C096 J3KN59 BNIP2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 0 6737300.0 2214000.0 2846900.0 1676400.0 False True 3032575.631100306 2721114.5445606434 1280468.8465417554 1.0 0.8972948660058132 0.4222380584378581 21.532112195297405 -6.941556353969901 0.6449247434524468 1.0052221454370323 0.2880449525399542 0.9983606956911962 0.010189659574069403 0.08706380721823323 0.0514303206591389 0.01003997420485789 0.04061506025117632 1.1440464189379417e-07 6.941556353969901 -0.717177192897078 down TLLAVTRPFISSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLLAVTRPFISSK 13 1 J3KN59;Q12982;Q12982-2;H7C096 J3KN59 BNIP2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 0 5286660.0 2796400.0 1684200.0 806060.0 False True 2325330.5015248996 1675126.8803124737 974603.4191996526 1.0 0.7203822765039047 0.41912468724791146 21.14900435179191 -6.970174605535547 0.25398046849541644 1.0910432497024412 0.039595257130818365 0.9999837124018068 0.0009572565610308438 0.07624608283298777 0.008827168330353808 0.006541964973677732 0.028688656198159614 1.071088593807655e-07 6.970174605535547 -1.0514479925716227 down TLLAVTRPFISSK(ub)FSQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLLAVTRPFISSKFSQK 17 2 J3KN59;Q12982;Q12982-2;H7C096 J3KN59 BNIP2 BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 1 23569100.0 11232600.0 10275200.0 2061300.0 True False 9340404.588552635 10219845.458132485 2492308.2996256445 1.0 1.0941544727792274 0.2668308718318428 23.15505361232727 -6.87859693665521 1.087559951718826 1.057344412294899 0.20974598987980483 0.9725374754723107 0.06128503328932426 0.1288818263421456 0.27983883421702654 0.04346073537447238 0.10473762931769279 1.322522481568555e-07 6.87859693665521 -0.8475984224150941 down TLLDK(ub)ALTQRPDYIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLLDKALTQRPDYIK 15 2 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 6036100.0 1324100.0 2365600.0 2346400.0 True False 1735907.9226026393 2012661.7010365794 2103617.03625811 1.0 1.1594288353837365 1.2118252407674746 20.727258994567638 -13.999999993861609 0.15555221572774677 0.22176038858380567 1.26594763222828 0.9995487746663232 0.001913518604086507 11.983038923777821 0.12447172772363446 2.815157183701573 0.04906719750464521 1.000000014134168e-14 13.999999993861609 1.0441872436444743 TLLDK(ub)ALTQRPDYIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLLDKALTQRPDYIK 15 2 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 10397400.0 3681100.0 4906900.0 1809400.0 True False 3060997.750380246 4880465.555756606 2187737.174279647 1.0 1.5944035094930535 0.7147137478320198 21.545570553909283 -6.724701079529548 1.742317107613044 1.359805546952538 0.7157046419349891 0.5345872804362237 0.2499951549916196 0.34629029233124553 2.0568127082707894 0.11381783693716596 0.28416657621650776 1.8849460322661963e-07 6.724701079529548 -0.644100905017549 TLLDK(ub)ALTQRPDYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLLDKALTQRPDYIK 15 2 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 11980500.0 3806600.0 2766700.0 5407200.0 True False 4927718.73930391 2612730.712875241 4423145.082557233 1.0 0.5302110065730569 0.8976050210166919 22.232488482623335 -9.845842819811796 6.399392417435621 1.0000000117652454 0.7139080137948247 0.4470589543872321 0.14998797832344976 2.5275932231261325e-08 4.396092766478353e-09 0.14522524203650009 0.04840841184814349 1.4261236439624982e-10 9.845842819811796 -0.28609199797042073 TLLEFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLLEFLK 7 0 Q14232;H0YGG4;Q14232-2;F5H0D0 Q14232 EIF2B1 Translation initiation factor eIF-2B subunit alpha 0 5931600.0 2053600.0 1592300.0 2285700.0 False True 2658425.682507883 1503687.1052558064 1869726.0532625178 1.0 0.5656306719988016 0.7033207907842177 21.34214070511639 -10.869700923000384 10.907492333491986 1.013857345121721 0.6344757313915107 0.9038136830587237 0.056211755607912375 0.01753738253437219 0.00020949821116408892 0.050389879344698525 0.018142266110877173 1.3498921661447617e-11 10.869700923000384 -0.3793816137302103 TLLENTAITIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLLENTAITIGR 12 0 Q92973-2;Q92973;Q92973-3;S4R398;O14787-2 Q92973-2;O14787-2 TNPO1;TNPO2 Transportin-1;Transportin-2 0 9957900.0 2488100.0 4183400.0 3286400.0 False True 3261923.194794678 3559253.026765478 2946354.853374809 1.0 1.0911516961666277 0.9032569675694855 21.637291382093363 -6.774836332143239 1.5563701207143839 1.0519598240071384 0.9020125379320352 0.7485507166005325 0.038470537619288765 0.25868803461554235 1.237318014743253 0.019477720364252715 0.04615430862430528 1.679436810035917e-07 6.774836332143239 -0.14994728607510321 TLLENTAITIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLLENTAITIGR 12 0 Q92973-2;Q92973;Q92973-3;S4R398;O14787-2 Q92973-2;O14787-2 TNPO1;TNPO2 Transportin-1;Transportin-2 0 13106500.0 2681400.0 3456600.0 6968500.0 False True 2596280.424724155 4836838.405930866 5143240.799481096 1.0 1.8629876649186543 1.981003573613411 21.308014786832796 -11.00461765105377 0.36580077042851766 3.956808533980057e-18 1.9972169885576456 0.9994158125526287 0.010569409187761478 2.8291095601985945 0.18144672371416107 2.4145452168800765 0.03333235586696023 9.894237911090052e-12 11.00461765105377 1.9972169885576456 TLLENTAITIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLLENTAITIGR 12 0 Q92973-2;Q92973;Q92973-3;S4R398;O14787-2 Q92973-2;O14787-2 TNPO1;TNPO2 Transportin-1;Transportin-2 0 13114300.0 2488100.0 4096700.0 6529500.0 False True 3408017.808374287 3915694.248024727 4987366.579273677 1.0 1.148965313034152 1.46342151353158 21.700501443616254 -6.958975387029335 0.4496419415650477 0.9898222527118817 1.6350231189926934 0.9997302870682085 0.0031724187562812965 0.08006919053092909 0.022499225579129183 0.004200792376948097 0.02601209863075158 1.0990681256602552e-07 6.958975387029335 0.6452008662808116 TLLESERER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLLESERER 9 1 O75792;A0A2R8Y658 O75792 RNASEH2A Ribonuclease H2 subunit A 0 12194600.0 1926600.0 6590800.0 3677200.0 False True 2525791.2572209416 5607478.330737182 3296718.618193116 1.0 2.2200877901948775 1.3052221195113347 21.268303982552524 -10.266069484339136 5.010443194084129 0.9998396714226236 1.7626549548535035 0.48094398296574137 0.37349234606201004 0.0006690522072827756 9.800404927127572e-05 0.3617071754285012 0.12054413635264465 5.419141806627601e-11 10.266069484339136 0.7628152834308799 TLLESERER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLLESERER 9 1 O75792;A0A2R8Y658 O75792 RNASEH2A Ribonuclease H2 subunit A 0 16602000.0 2092800.0 8555900.0 5953300.0 False True 2026365.2095408016 11972315.488429071 4393952.134828268 1.0 5.908271338285629 2.168391025536798 20.95046278221471 -6.577243598338547 2.2783064832571043 4.34801762230974 2.1773672588669535 0.0 2.133808787064369 0.7076452789460386 6.905333940315559 0.7879028013785322 2.386242040614261 2.647014995796439e-07 6.577243598338547 -2.1706503634427867 TLLESERER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLLESERER 9 1 O75792;A0A2R8Y658 O75792 RNASEH2A Ribonuclease H2 subunit A 0 11191100.0 1926600.0 4589700.0 4674800.0 False True 2638916.084407339 4386911.877891744 3570708.5205281507 1.0 1.662391579562856 1.35309665268499 21.331514044075416 -10.061985716497201 4.502559293748885 0.9999714761993106 1.507744116121856 0.7822874663468323 0.1262691252591839 43781703.93701108 0.6613683357576225 13776.741964913286 0.043225280121308635 8.669903897194422e-11 10.061985716497201 0.5077726399225455 TLLESERER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLLESERER 9 1 O75792;A0A2R8Y658 O75792 RNASEH2A Ribonuclease H2 subunit A 0 17508400.0 2092800.0 11808800.0 3606800.0 False True 1740255.9267598737 11745183.650536718 4360965.204041023 1.0 6.749112857443155 2.5059332578516558 20.730868057648987 -6.568267141474002 2.312545345436629 4.942234928963668 2.5141738424232294 0.0 2.504985144888793 0.7355679430454423 7.381631337505558 0.916220652919396 2.8108749518608422 2.702295627561632e-07 6.568267141474002 -2.4280610865404384 TLLFTFNVPGSGNTYPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLLFTFNVPGSGNTYPK 17 0 Q96A33;Q96A33-2;A0A087WYW6 Q96A33 CCDC47 Coiled-coil domain-containing protein 47 0 13585200.0 4016300.0 6317100.0 3251800.0 False True 5265408.193904527 5374613.303862944 2915334.929468175 1.0 1.0207401033190242 0.5536769082486516 22.32811394796251 -6.896510128843686 0.9830834738705685 1.0213215767764543 0.5079846652037737 0.9847481009594965 0.026608219167914924 0.1140193298126953 0.19226836103394568 0.02042582460936745 0.05227155132530079 1.2690825458912908e-07 6.896510128843686 -0.5133369115726806 TLLFTFNVPGSGNTYPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLLFTFNVPGSGNTYPK 17 0 Q96A33;Q96A33-2;A0A087WYW6 Q96A33 CCDC47 Coiled-coil domain-containing protein 47 0 16865600.0 5559200.0 5347700.0 5958700.0 False True 5382726.238952232 7483064.497887084 4397937.7128317375 1.0 1.3901997177073029 0.817046514646417 22.3599056222592 -6.7234173996910975 1.7471256473521857 1.2365273168123438 0.8177715788852745 0.5285076852311413 0.16413294764515046 0.34873900103863686 2.082186742679202 0.07454276597737228 0.1863747091399323 1.8905257641060914e-07 6.7234173996910975 -0.4187557379270693 TLLFTFNVPGSGNTYPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLLFTFNVPGSGNTYPK 17 0 Q96A33;Q96A33-2;A0A087WYW6 Q96A33 CCDC47 Coiled-coil domain-containing protein 47 0 22318800.0 4016300.0 5866500.0 12436000.0 False True 5501234.646426445 5607298.632078765 9498872.927459596 1.0 1.0192800330233538 1.7266801978043207 22.391324009485402 -6.9127409645408315 0.8768637084300115 0.9799496686709991 1.8236685060561997 0.9919152796262672 0.03040097021501907 0.10263371699799066 0.12914342942026905 0.025231920125430032 0.07104784200151762 1.2225286213955403e-07 6.9127409645408315 0.8437188373852006 TLLGDGPVVTDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLLGDGPVVTDPK 13 0 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 45186100.0 3793100.0 19206000.0 22187000.0 False True 4972790.8324326575 16340539.66440164 19891302.072732177 1.0 3.2859897419831654 4.000027900429803 22.245624318510593 -9.537392858321308 0.3403801769060301 9.161769746576079e-20 4.189324227448574 0.9985123161843122 0.04935378154085087 0.8966365535755068 0.13925332746816033 1.2498326180270107 0.21594283323312888 2.901396893238471e-10 9.537392858321308 4.189324227448574 TLLGDGPVVTDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLLGDGPVVTDPK 13 0 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 21905000.0 12326000.0 9579000.0 0.0 False True 11934717.876911286 13403944.653825087 0.0 1.0 1.12310527924218 0.0 23.5086611273726 -6.948591089776376 1.2064082741237367 1.0690001166452725 5.387086777265761e-19 0.9713928574724688 0.0850651662811592 0.10825034738407278 0.3132625421228898 0.058592223153945765 0.1114836849977836 1.1256643450858703e-07 6.948591089776376 -1.0690001166452725 down TLLGDGPVVTDPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLLGDGPVVTDPK 13 0 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 105502500.0 0.0 97610000.0 7892500.0 False True 0.0 80190732.869589 6332543.915594362 0.0 TLLGDGPVVTDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLLGDGPVVTDPK 13 0 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 43549100.0 3793100.0 23595000.0 16161000.0 False True 5195511.574673248 22552494.8817691 12344104.646242704 1.0 4.340765015654392 2.375917071654111 22.308834380033485 -9.496003006005543 8.505650019400136 0.9999540975073005 3.3583410436801024 0.6576342237250739 0.8021458145975245 0.0 0.0 0.7766743450936515 0.25889144836455047 3.191515764681288e-10 9.496003006005543 2.3583869461728018 TLLGDGPVVTDPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLLGDGPVVTDPK 13 0 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 20570200.0 12326000.0 5429900.0 2814300.0 False True 10249615.134385617 5400648.050949235 3402757.1181470184 1.0 0.5269122772064906 0.33198876967891017 23.289066402806878 -13.99999999986507 0.12180306662372042 3.252150053591894 0.028305123407298988 0.9996841423311894 0.004984882848309783 11.957181712064443 0.10763725645152522 6.503579023921841 0.2695295506166588 1.0000000003106884e-14 13.99999999986507 -3.223844930184595 TLLGDGPVVTDPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLLGDGPVVTDPK 13 0 P52566;F5H3P3;H0YGX7;F5H6Q0;F5H2R5 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 0 23163000.0 0.0 11000000.0 12163000.0 False True 0.0 10387840.330222866 9949458.802919023 0.0 TLLGFFLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLLGFFLAK 9 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 7696800.0 1421200.0 2704500.0 3571100.0 False True 1863206.962920379 2300999.142058432 3201596.828410052 1.0 1.2349670153936418 1.7183259252058019 20.82935650543682 -6.959490599119506 0.44256065597417055 0.9831713753682769 1.9890471717700393 0.999750820074554 0.004720511278295148 0.07988368624396322 0.021808058781099468 0.006393641855522855 0.04003039983539828 1.097765052598142e-07 6.959490599119506 1.0058757964017624 TLLGFFLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLLGFFLAK 9 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 4980100.0 1925700.0 1308300.0 1746100.0 False True 1864569.7075748865 1830711.0126943677 1288744.0281228302 1.0 0.9818410141798579 0.6911750324416716 20.830411303090443 -6.919653235365298 0.8273078625182514 1.0064939093659173 0.6446764062110585 0.9940837628865847 0.010883435210178103 0.09837617952762791 0.10667912216908758 0.009360003709912693 0.027944827352292624 1.2032247721032547e-07 6.919653235365298 -0.36181750315485883 TLLGFFLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLLGFFLAK 9 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 6597900.0 1709300.0 2130000.0 2758600.0 False True 2593133.0665686056 1749884.8582340393 2213361.5008626706 1.0 0.6748149105011396 0.8535472125969716 21.306264809280506 -10.10283576546821 5.01694983866933 1.0000074396154062 0.7641810625365527 0.698893075989086 0.0729671567840087 6.072010162122197e-06 1.0858984460730072e-06 0.07065237451792016 0.023550048586659003 7.891584925177319e-11 10.10283576546821 -0.23582637707885346 TLLGFFLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLLGFFLAK 9 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 8925200.0 1421200.0 2794400.0 4709600.0 False True 1946656.0464858867 2670934.1681549298 3597289.4772566524 1.0 1.3720627087545916 1.84793275820374 20.89256656695971 -6.967770316177361 0.3068065087340749 0.9238678847617935 2.311184522702111 0.9999593956782149 0.0022113250190561335 0.07703303315666885 0.011606370854074129 0.007640415857484623 0.04238102255282711 1.0770346706394822e-07 6.967770316177361 1.3873166379403172 TLLGFFLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLLGFFLAK 9 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 4556000.0 1925700.0 1082600.0 1547700.0 False True 1601304.872974718 1076767.818920725 1871316.914243731 1.0 0.6724314882777013 1.1686200084855896 20.61081657852472 -6.728663937023602 1.7280419069854809 0.8025784586118355 1.1682566509691146 0.5530829931058097 0.13771713730828894 0.3387506401681745 1.981095742068665 0.06317073222642643 0.15699512823989822 1.8678244797483181e-07 6.728663937023602 0.36567819235727905 TLLGFFLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLLGFFLAK 9 0 A0A087WU64;A6NMQ1;P09884 A0A087WU64 POLA1 DNA polymerase;DNA polymerase alpha catalytic subunit 0 7967000.0 1709300.0 2358600.0 3899100.0 False True 2212722.5453402437 2227341.8366239723 3189503.808144495 1.0 1.0066069247201892 1.441438654322589 21.077391131372956 -6.910205962108514 0.8943312391385944 0.9866232572388811 1.4978813027970506 0.9909985991873109 0.019597196318079036 0.1042833383415117 0.13803152856272669 0.016060650441263615 0.044398172531359754 1.2296854599808622e-07 6.910205962108514 0.5112580455581694 TLLHLAVSLGHLESAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLLHLAVSLGHLESAR 16 0 Q8IZ07 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 0 31389400.0 6168900.0 9368500.0 15852000.0 False True 9358672.30699999 7696617.978575408 12718845.25182157 1.0 0.8224049016887344 1.3590437654610767 23.15787244187098 -6.817510883321314 1.3825414432703178 0.9040275598629555 1.3701510932655683 0.87856861185966 0.07778455158375959 0.19674231760239688 0.7395844551617238 0.044218667564251406 0.10199411705256523 1.5222609848870637e-07 6.817510883321314 0.4661235334026128 TLLHLAVSLGHLESAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLLHLAVSLGHLESAR 16 0 Q8IZ07 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 0 27914400.0 6168900.0 9349500.0 12396000.0 False True 7985762.657198526 8829192.106128978 10140055.19370089 1.0 1.1056166436614752 1.2697666621184192 22.928998763963428 -6.9646606142902066 0.36383148239165297 0.9864601080310574 1.3945820748111328 0.9999059730704781 0.00107625154418403 0.0780763536226199 0.015267283126063553 0.0021860963495535096 0.013989021375356018 1.0847742954553698e-07 6.9646606142902066 0.4081219667800754 TLLILFKPLISFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLLILFKPLISFK 13 1 Q07960;H0YE29;E9PNR6 Q07960 ARHGAP1 Rho GTPase-activating protein 1 0 459450000.0 138300000.0 185140000.0 136010000.0 False True 209811211.08432597 152100320.49457744 109127563.88469936 1.0 0.7249389568293673 0.5201226536976592 27.644516528261104 -7.370452229711228 0.1359991125128914 1.3208338855093529 8.317749699040937e-11 0.9999943578590977 0.0004669698511166698 0.11842093699472261 0.009289367527251478 0.03100868136282597 0.054622898311771556 4.261355538512077e-08 7.370452229711228 -1.3208338854261754 TLLILFKPLISFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLLILFKPLISFK 13 1 Q07960;H0YE29;E9PNR6 Q07960 ARHGAP1 Rho GTPase-activating protein 1 0 360666000.0 138300000.0 158580000.0 63786000.0 False True 179032076.3005651 149754883.59697682 52177602.499629326 1.0 0.8364695684228298 0.2914427603019685 27.415642850353553 -6.949064283110412 0.5690234488018291 1.0068195009208842 0.0946384179102112 0.9991257935620995 0.008956455769315927 0.08386366896387071 0.037534228514200185 0.009499419027888778 0.04540062478501278 1.124438525258339e-07 6.949064283110412 -0.912181083010673 down TLLSDPTYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLLSDPTYR 9 0 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 0 24962200.0 4259300.0 11390000.0 9312900.0 False True 5583983.547119879 9690656.397872252 8349290.443644808 1.0 1.7354378493594458 1.4952211755622427 22.412863260061652 -10.203911183395785 4.992148443995475 0.9999347025652502 1.6153295124615432 0.8974231536374384 0.09806804642112302 7.128150516866738e-05 1.1367380974884674e-05 0.09496399958542835 0.03165132588165125 6.253005585350765e-11 10.203911183395785 0.615394809896293 TLLSDPTYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLLSDPTYR 9 0 P31948;P31948-2;P31948-3;F5H783 P31948 STIP1 Stress-induced-phosphoprotein 1 0 29019300.0 4259300.0 11927000.0 12833000.0 False True 5834078.3132545315 11400025.702685319 9802109.70393124 1.0 1.954040568290869 1.6801470905287093 22.476073321584543 -10.069568501463618 4.822487924420427 0.9999740622610696 1.8170938294190895 0.9222782202191964 0.11181654410119943 3.200871214372263e-05 6.17590550204787e-06 0.10826942344798171 0.03608863442279903 8.519841169431768e-11 10.069568501463618 0.8171197671580199 TLLTEK(ub)KEGEENIGGVEWLQIK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLLTEKKEGEENIGGVEWLQIK 22 2 Q969F1 Q969F1 GTF3C6 General transcription factor 3C polypeptide 6 2 44599400.0 7618400.0 20733000.0 16248000.0 True False 9862168.98111515 19579190.324228257 13291030.718558598 1.0 1.9852823817681504 1.347678258607138 23.233473541908516 -10.255897373041805 4.982006310461323 0.9998691844334965 1.6664803201880833 0.5929727015296354 0.2603007932747637 0.0003782939189569473 5.650095756487781e-05 0.25208405069989537 0.08401171977958706 5.5475679055159976e-11 10.255897373041805 0.6666111357545869 TLLVADPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLLVADPR 8 0 P62249;M0R210 P62249 RPS16 40S ribosomal protein S16 0 12919400.0 1904700.0 6204400.0 4810300.0 False True 2497080.1451410353 5278727.704561779 4312576.299655815 1.0 2.1139600644510494 1.7270476112060231 21.25181069541288 -10.050877319543927 4.4800372369546695 0.999949970547926 1.920503837895439 0.8829975458059391 0.15795634784254725 48522806.587536745 65370663.03705019 32131.94393993789 0.057806102594311674 8.894523368172682e-11 10.050877319543927 0.9205538673475131 TLLVADPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLLVADPR 8 0 P62249;M0R210 P62249 RPS16 40S ribosomal protein S16 0 8895300.0 3014200.0 2608200.0 3272900.0 False True 2918515.870889663 3649667.8615833153 2415629.3051046375 1.0 1.2505218484457896 0.8276909950016038 21.476803482941467 -6.746189924526039 1.6640383249811335 1.1479815319781703 0.8270933504878534 0.6323845539508309 0.10525688251383869 0.30673408703125615 1.669881200885859 0.04999503004244292 0.12185951831595572 1.793948930213884e-07 6.746189924526039 -0.32088818149031695 TLLVADPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLLVADPR 8 0 P62249;M0R210 P62249 RPS16 40S ribosomal protein S16 0 40323000.0 6721000.0 29071000.0 4531000.0 False True 10196248.370916525 23883052.917240303 3635445.8639921476 1.0 2.3423373037247317 0.3565474017249114 23.281535085791912 -6.724611968048058 1.7425358420888275 1.8126052556189458 0.3587700550172984 0.5342615103724744 0.5645652685925991 0.34643677877019985 2.0581339959026277 0.25700282257832857 0.6417448911488912 1.8853328379344404e-07 6.724611968048058 -1.4538352006016475 TLLVADPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLLVADPR 8 0 P62249;M0R210 P62249 RPS16 40S ribosomal protein S16 0 10228700.0 1904700.0 5242700.0 3081300.0 False True 2608919.062582087 5011060.178709512 2353560.4013654883 1.0 1.9207419082407216 0.9021208956310565 21.31502075693577 -6.668643428145556 1.9423340304838 1.5883900247306693 0.906273686010916 0.27302320425899984 0.3912336032988983 0.46421637907937685 3.375136785044709 0.16223943933543059 0.4342072938961624 2.1446507161299438e-07 6.668643428145556 -0.6821163387197533 TLLVADPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLLVADPR 8 0 P62249;M0R210 P62249 RPS16 40S ribosomal protein S16 0 5449280.0 3014200.0 1684300.0 750780.0 False True 2506440.8517008857 1675226.3415926269 907764.6267854943 1.0 0.6683685914454388 0.36217277027282724 21.257208758375743 -7.3218905782507235 0.2420339463836662 1.1284616498238356 2.0999151933153732e-14 0.9999437921355988 0.0019527163103784434 0.10896330407105322 0.016427248057426645 0.017298594176284092 0.0494641808821564 4.765510400920745e-08 7.3218905782507235 -1.1284616498238145 down TLLVADPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLLVADPR 8 0 P62249;M0R210 P62249 RPS16 40S ribosomal protein S16 0 17516800.0 6721000.0 5068000.0 5727800.0 False True 8700466.990716547 4785961.344869962 4685399.172191028 1.0 0.5500809726623425 0.538522722652747 23.05266140788436 TLLWTELFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLLWTELFR 9 0 E9PKH6;E9PPW7;O00217;E9PN51;F8W9K7 E9PKH6 NDUFS8 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial 0 9053100.0 2177400.0 3358400.0 3517300.0 False True 3303274.9892625553 2759067.2807010324 2822104.113312647 1.0 0.8352520724642984 0.8543352044519528 21.655465644649013 -9.90858907436218 5.213440001761363 1.0000003168867844 0.8447936384966481 0.9887889732321798 0.007790656017760416 2.869487983693099e-08 6.004576280204203e-09 0.007543285593125651 0.0025144234167118634 1.23427213838982e-10 9.90858907436218 -0.15520667839013624 TLLWTELFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLLWTELFR 9 0 E9PKH6;E9PPW7;O00217;E9PN51;F8W9K7 E9PKH6 NDUFS8 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial 0 10367800.0 2177400.0 4655400.0 3535000.0 False True 2818687.2229707194 4396322.897574505 2891666.27216301 1.0 1.5597058310503342 1.025891148403254 21.426591966741462 -10.438710347429923 3.732826726606342 0.9976489428331357 1.2927984897559022 0.28629516259351373 0.21792893171043154 156784643.55297 9631.439328800257 3169014.8002731223 0.07460280519294754 3.641578301044245e-11 10.438710347429923 0.2951495469227665 TLMELLNQMDGFDTLHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLMELLNQMDGFDTLHR 17 0 A0A087X2I1;P62333 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 0 33537300.0 8621700.0 15996000.0 8919600.0 False True 13079749.230699442 13141388.822681554 7156637.150400444 1.0 1.004712597382023 0.5471540030448842 23.64083154548374 -6.9045725165667475 0.931897546361726 1.016711384155108 0.49440268415237926 0.9887073596038685 0.022804123107821667 0.10811768399172583 0.15904181293278438 0.018182861425075896 0.04849249254783299 1.2457402117272104e-07 6.9045725165667475 -0.5223087000027289 TLMELLNQMDGFDTLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLMELLNQMDGFDTLHR 17 0 A0A087X2I1;P62333 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 0 18252700.0 8621700.0 4946400.0 4684600.0 False True 11160960.609114835 4671128.491764952 3832050.8680551164 1.0 0.41852387579884265 0.3433441799736835 23.411957867576188 -13.999999999999998 0.28839154129031536 5.965436090540968 0.32252341966834386 0.9996238638101951 0.005691040291785736 15.870812438984732 0.170265923219597 46.709827694365735 0.02860128248121708 1.0000000000000041e-14 13.999999999999998 -5.642912670872624 TLMIQLLR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TLMIQLLR 8 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 14317710.0 2764000.0 7413020.0 4140690.0 False True 3623630.766614071 6307026.31172564 3712251.1191031383 1.0 1.7405267583647712 1.0244562313869177 21.789004527381216 -10.615848244605903 5.888525216325977 0.9979081310000166 1.3824914948758444 0.27558617817385234 0.29233456849026634 0.008065693119634617 0.0005261836982386592 0.284370479745702 0.09435057627362772 2.4218751740319896e-11 10.615848244605903 0.3845833638758278 TLMIQLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLMIQLLR 8 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 14201500.0 6920400.0 3783200.0 3497900.0 False True 6700715.690035441 5293851.489127365 2581695.0552493236 1.0 0.7900426960361551 0.38528646411435324 22.675883764494905 -6.9607574918469135 0.424622977869179 1.0170251520916016 0.14291918710262244 0.9997972699340778 0.003632498470509416 0.07943163457969812 0.020139632688186183 0.005253155499125343 0.03365141182976064 1.0945673973399802e-07 6.9607574918469135 -0.8741059649889792 down TLMIQLLR ddPTM_RPMI8226_Bortezomib_8h_R1 2 TLMIQLLR 8 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 69186100.0 21971400.0 28989400.0 18225300.0 False True 33332220.124498628 23816015.074783977 14623061.466567237 1.0 0.7145043140189633 0.4387064951554046 24.99041407694724 -6.971547268695929 0.21808731269037285 1.1302978589434358 0.015142436198958066 0.9999920658396331 0.0006454596708145013 0.07580376768842881 0.007206206551959959 0.0077524632058643475 0.028067944580303233 1.0677085766054653e-07 6.971547268695929 -1.1151554227444778 down TLMIQLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TLMIQLLR 8 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 28640950.0 2764000.0 10219350.0 15657600.0 False True 3785925.4942914303 9767825.326128718 11959597.358394293 1.0 2.5800363321615905 3.158962683345843 21.852214588904108 -9.639611943904683 0.2798827741982201 1.6523603537864478e-15 3.4237011352588484 0.9988830056108832 0.030494816563161206 1.0279748126615882 0.11635344994493753 1.122796089181511 0.22194934257307627 2.2929155315229142e-10 9.639611943904683 3.4237011352588467 TLMIQLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLMIQLLR 8 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 14476700.0 6920400.0 4306200.0 3250100.0 False True 5754619.225701949 4283001.645886222 3929680.8832354853 1.0 0.7442719453542612 0.6828741796997251 22.45628903992918 -13.999999999999998 0.20041073590288233 2.423782349741757 0.6431606525056318 0.9994869502674704 0.003110597571634404 12.539088120783816 0.14194849021706055 6.999364865579809 0.03897559843653052 1.0000000000000041e-14 13.999999999999998 -1.7806216972361253 TLMIQLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLMIQLLR 8 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 40285000.0 12222000.0 16727000.0 11336000.0 False True 15821619.931637766 15796127.74578528 9272964.317182425 1.0 0.9983887752352393 0.5860944933103661 23.915393985115376 -6.907757335968549 0.9108750022886916 1.0136884218505637 0.5352919272527991 0.990047286412097 0.019427729085020835 0.10591968861322384 0.14695128878905955 0.01573143367919889 0.04277966490752576 1.236638217706811e-07 6.907757335968549 -0.4783964945977647 TLMMFVTVSGSPTEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLMMFVTVSGSPTEK 15 0 Q14696 Q14696 MESDC2 LDLR chaperone MESD 0 40656000.0 12444000.0 12779000.0 15433000.0 False True 18878457.77825997 10498487.60721727 12382660.785475794 1.0 0.5561093883053893 0.6559148491321893 24.170237576870267 -10.343293080382363 8.68781472468674 1.0000007764881245 0.6060121187188033 0.9540813047402497 0.04074540876149919 6.128111356714346e-07 4.635175397751723e-08 0.03945165056972836 0.013150524130641673 4.536353808880056e-11 10.343293080382363 -0.3939886577693211 TLMNLGGLAVAR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TLMNLGGLAVAR 12 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 350704000.0 101726000.0 133052000.0 115926000.0 False True 133363771.11598538 113201160.23263389 103931089.56071326 1.0 0.8488149314117982 0.7793052692723067 26.990791564077323 -13.999999999999998 0.10431808064027491 1.7381011018695818 0.6406905760019342 0.9997719326017837 0.0013913557133775148 12.049063749833358 0.09703233678519359 1.894968243886515 0.12335788937644168 1.0000000000000041e-14 13.999999999999998 -1.0974105258676476 TLMNLGGLAVAR ddPTM_RPMI8226_Bortezomib_2h_R1 2 TLMNLGGLAVAR 12 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 344509600.0 142762000.0 58618600.0 143129000.0 False True 138230098.45396805 82025312.67196067 105639221.1220392 1.0 0.5933969055174759 0.7642273448659814 27.042496543873177 -10.180437378157045 5.356709708653775 1.0000130797694369 0.6788121251916506 0.8249702788465293 0.069741234823492 1.0894442620180741e-05 1.6668753126626274e-06 0.0675294085519187 0.0225088867512375 6.600283982978341e-11 10.180437378157045 -0.3212009545777863 TLMNLGGLAVAR ddPTM_RPMI8226_Bortezomib_8h_R1 2 TLMNLGGLAVAR 12 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 517077000.0 103865000.0 305695000.0 107517000.0 False True 157570798.5486152 251141338.84406346 86266217.82362479 1.0 1.5938317325121574 0.547475919511883 27.23142495447333 -6.752740656535466 1.6395763198554945 1.348025512955835 0.5449390730583673 0.660718266772711 0.2495744398678659 0.29529490069108183 1.5626102704128355 0.1202018091932427 0.29099717526185154 1.7670927434771651e-07 6.752740656535466 -0.8030864398974676 TLMNLGGLAVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TLMNLGGLAVAR 12 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 382827200.0 101726000.0 126146200.0 154955000.0 False True 139336851.2417839 120572643.7743004 118357820.39839992 1.0 0.865332054655642 0.8494365944370297 27.054001625600215 -13.999999999999998 0.30149600161886125 2.2390209838552955 0.8455857863043823 0.9996531591869187 0.0012578687001542318 16.686545418286148 0.1744257818823185 12.908565591683615 0.005707814888171254 1.0000000000000041e-14 13.999999999999998 -1.3934351975509132 TLMNLGGLAVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TLMNLGGLAVAR 12 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 275777100.0 142762000.0 73487700.0 59527400.0 False True 118712928.42894374 73091807.17393358 71974304.11640002 1.0 0.6157021660676417 0.606288675285107 26.822901819307454 TLMNLGGLAVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TLMNLGGLAVAR 12 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 337915000.0 103865000.0 142582000.0 91468000.0 False True 134455289.98523617 134647186.360349 74821762.54093531 1.0 1.0014272132776174 0.5564806155946047 27.00255127656578 -6.906177488452327 0.9213839277398893 1.015496561835164 0.5034451624239169 0.9893970633007613 0.021563502396121585 0.10700001649023567 0.15288470267649198 0.017327232898324735 0.046653650052975004 1.241144969992615e-07 6.906177488452327 -0.512051399411247 TLNDELEIIEGMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 TLNDELEIIEGMK 13 0 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 59419700.0 4438100.0 25234300.0 29747300.0 False True 5818392.078621538 21469440.802530974 26669334.752250627 1.0 3.689926789467477 4.583626265105355 22.472189086598426 -9.3661621164106 0.35047181665365934 3.8623130751632245e-21 4.810145383035885 0.9983336214545284 0.06217236031070094 0.7419483224287765 0.1381165798372681 1.2026851867843857 0.26021686069432837 4.303659305696029e-10 9.3661621164106 4.810145383035885 TLNDELEIIEGMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 TLNDELEIIEGMK 13 0 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 149593900.0 45975600.0 51433000.0 52185300.0 False True 44516129.74377111 71970465.11955178 38516404.40455778 1.0 1.6167278138015175 0.8652235633747374 25.407824833661806 -6.688644442148781 1.8713589524096401 1.387147253318992 0.8678734893369958 0.36399619381830883 0.2609060142969512 0.41960872009787065 2.8479950037273474 0.11158188034348639 0.2910508883521617 2.0481207514929448e-07 6.688644442148781 -0.5192737639819961 TLNDELEIIEGMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLNDELEIIEGMK 13 0 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 296479000.0 27327000.0 242560000.0 26592000.0 False True 41457056.87130423 199273272.8700702 21336079.54431236 1.0 4.806739501279052 0.5146549503151243 25.305114364163728 -6.672667266406684 1.9276516487261899 3.4242452354695696 0.5317033728915158 0.29094967054560683 1.6160369346437329 0.45507227727965976 3.262461670824068 0.674262033218845 1.795391349352281 2.1248718035617898e-07 6.672667266406684 -2.892541862578054 TLNDELEIIEGMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TLNDELEIIEGMK 13 0 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 62946400.0 4438100.0 22447600.0 36060700.0 False True 6078985.505142844 21455790.807713494 27543905.353428908 1.0 3.529501886385782 4.531003623898537 22.535399148121318 -9.191250529224948 0.32102008968799267 5.242257132054813e-19 4.8869478081199444 0.9984555495220194 0.05839259938016504 0.6061745983396297 0.11942324513678225 1.042148949510783 0.3199571705762317 6.437977740633142e-10 9.191250529224948 4.8869478081199444 TLNDELEIIEGMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TLNDELEIIEGMK 13 0 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 85679700.0 45975600.0 27715000.0 11989100.0 False True 38230748.46442152 27565693.794003256 14495965.378664814 1.0 0.7210346357633195 0.37917032652800714 25.188230109096082 -6.968398446385642 0.29393380685147524 1.0637317240253448 0.02585269599757094 0.9999670554837284 0.0014572253186854358 0.07682587079259946 0.010880498914513087 0.005849425461438049 0.030863386604242656 1.0754780563050279e-07 6.968398446385642 -1.0378790280277739 down TLNDELEIIEGMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLNDELEIIEGMK 13 0 P10809;E7ESH4;E7EXB4 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 86871000.0 27327000.0 30444000.0 29100000.0 False True 35375340.19570167 28749764.63757318 23804098.591214627 1.0 0.8127063790348074 0.6729009094902492 25.076240686256178 -6.974342987358349 0.1138313579468309 1.276638831763089 0.20539141392346863 0.999999557306607 8.897399557920172e-05 0.07491696040553139 0.0033739005853427326 0.01059420337793781 0.020896706709267673 1.0608574060981085e-07 6.974342987358349 -1.0712474178396203 TLNMTTSPEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLNMTTSPEEK 11 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 4284400.0 1673500.0 0.0 2610900.0 False True 1620375.6585275875 0.0 1927026.9646789394 1.0 0.0 1.1892470456079312 20.62789688729052 -10.757883680088712 6.204429746625738 1.0127545364790163 0.5946235274160269 0.13414027753002178 0.4855080733086376 0.08551350665684311 0.003337001831140408 0.4693013989557713 0.15669705686446692 1.7462898104297313e-11 10.757883680088712 -0.4181310090629894 TLNMTTSPEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLNMTTSPEEK 11 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 6084840.0 872840.0 2478700.0 2733300.0 False True 1195552.5356140882 2369182.83803522 2087750.8340805185 1.0 1.9816635132794926 1.7462644023486247 20.18924609644994 -10.024706074094926 4.925033332048828 0.9999864124772594 1.8639639578249432 0.9472589963825602 0.09610128465188286 1.433798612100237e-05 2.8393264608154737e-06 0.0930511306585398 0.031016556245117313 9.447000229464474e-11 10.024706074094926 0.8639775453476838 TLNMTTSPEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLNMTTSPEEK 11 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 2351720.0 1673500.0 0.0 678220.0 False True 1391589.3986203421 0.0 820032.6662650283 1.0 0.0 0.5892777475008288 20.408302162724798 -10.045056941234941 6.4484075113198145 1.0000004903989461 0.2946388737504095 0.6564032606712575 0.24057163302562798 1.6962560307913326e-06 2.513710038781365e-07 0.23293264519228285 0.07764416068984553 9.014529385248555e-11 10.045056941234941 -0.7053616166485366 TLNMTTSPEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLNMTTSPEEK 11 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 8005000.0 2591700.0 2334400.0 3078900.0 False True 3355006.740044643 2204488.587897478 2518571.7921818094 1.0 0.6570742650335613 0.7506905312948182 21.677884234056403 -10.071689464188688 7.145118064159557 1.0000000689566009 0.7038823981641903 0.9302662943825468 0.03821868066076815 4.196540967994137e-08 5.4793693430526904e-09 0.03700508669952607 0.01233502614276451 8.478334281396071e-11 10.071689464188688 -0.2961176707924106 TLNQQLTNHIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLNQQLTNHIR 11 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3;K7EMQ3 P50570 DNM2 Dynamin-2 0 3931400.0 0.0 1702300.0 2229100.0 False True 0.0 1627086.7572466864 1702632.489755562 0.0 TLPAHSDPVSAVHFNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLPAHSDPVSAVHFNR 16 0 P61964 P61964 WDR5 WD repeat-containing protein 5 0 6154700.0 1142100.0 2853000.0 2159600.0 False True 1497304.1601121314 2427343.5209069005 1936145.3083459868 1.0 1.6211425744820742 1.2930875101562471 20.513935887389014 -10.10955575319118 4.7766861617889695 0.9999762567554715 1.4571150422098214 0.7213542948459866 0.1339279192085425 3.6381062107086444e-05 6.781883592096897e-06 0.12968237459820106 0.043225050054437615 7.770415585404626e-11 10.10955575319118 0.4571387854543498 TLPAHSDPVSAVHFNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLPAHSDPVSAVHFNR 16 0 P61964 P61964 WDR5 WD repeat-containing protein 5 0 4383000.0 1484500.0 1225600.0 1672900.0 False True 1437375.3600742158 1714988.4714195651 1234717.3040757566 1.0 1.1931389107233725 0.8590082579487133 20.455005429590646 -6.749949301316238 1.6498292897209712 1.1135713323344176 0.8583378026981843 0.6488674365960794 0.08115815528453149 0.30011753484661996 1.6072029443545568 0.03885826768667402 0.09434989291503014 1.7784870149976645e-07 6.749949301316238 -0.25523352963623336 TLPAHSDPVSAVHFNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLPAHSDPVSAVHFNR 16 0 P61964 P61964 WDR5 WD repeat-containing protein 5 0 18005700.0 2132100.0 12193000.0 3680600.0 False True 3234551.5773889446 10017063.885656176 2953127.796735709 1.0 3.0968941585845227 0.9129944989529548 21.625134287131065 -6.655384768630895 1.9891329594523985 2.3548136389988947 0.9221167431677717 0.21627352124681753 0.8937977473510952 0.4954490937503987 3.76332589374984 0.3636419949840942 0.9904765313730097 2.2111348589588474e-07 6.655384768630895 -1.432696895831123 TLPAHSDPVSAVHFNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLPAHSDPVSAVHFNR 16 0 P61964 P61964 WDR5 WD repeat-containing protein 5 0 5175100.0 1142100.0 1552600.0 2480400.0 False True 1564365.2340919839 1484000.998238385 1894580.6054415202 1.0 0.9486282141137934 1.211085853963768 20.577145948911905 -6.8559104988446995 1.2062500152323097 0.972377738422642 1.2228359819901726 0.9484677152449196 0.02578087867727215 0.15107699538761318 0.42006020816749456 0.016695235715209793 0.038808778999897965 1.3934439398942573e-07 6.8559104988446995 0.25045824356753066 TLPGSDWTPNAQFITR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLPGSDWTPNAQFITR 16 0 P56192;P56192-2 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 22181800.0 5565200.0 6824000.0 9792600.0 False True 7296031.093473467 5805885.799743658 8779355.689252121 1.0 0.7957594650243758 1.2033056845255958 22.798680447168987 -6.770481676949949 1.572921264774916 0.8829234153792945 1.2056226938583647 0.7322851726919829 0.08608705209293258 0.2656532956020303 1.2972187654095695 0.043141114519196826 0.1026354015920079 1.6963611708759684e-07 6.770481676949949 0.3226992784790702 TLPGSDWTPNAQFITR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLPGSDWTPNAQFITR 16 0 P56192;P56192-2 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 16444100.0 4921600.0 3662500.0 7860000.0 False True 4765366.5019476395 5124955.349685189 5801230.205054368 1.0 1.0754588020859641 1.2173733547426757 22.184155744678456 -6.961229991477144 0.4177412283379269 0.9935724844176562 1.3045932347110667 0.9998131199758111 0.0012318827781034965 0.07926468686636802 0.01952953855483346 0.001833314394702331 0.011820824768271999 1.0933771877603874e-07 6.961229991477144 0.3110207502934105 TLPGSDWTPNAQFITR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLPGSDWTPNAQFITR 16 0 P56192;P56192-2 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 20651700.0 5565200.0 6608600.0 8477900.0 False True 7622804.833875074 6316610.200282235 6475594.627831267 1.0 0.8286464546766008 0.8495028757727463 22.86189050869188 -9.9704008087493 5.523791553284101 1.000000330623035 0.8390746652673083 0.9875590012646812 0.008514598258553796 3.4672341733914815e-08 6.449594567434774e-09 0.008244241266358412 0.0027480747711276367 1.0705308602738622e-10 9.9704008087493 -0.1609256653557266 TLPGSDWTPNAQFITR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLPGSDWTPNAQFITR 16 0 P56192;P56192-2 P56192 MARS Methionine--tRNA ligase, cytoplasmic 0 9525600.0 4921600.0 4604000.0 0.0 False True 4092528.463848148 4579197.338177551 0.0 1.0 1.1189164299352958 0.0 21.964561020112733 -6.950628733528041 1.2028118713340967 1.067158168146552 3.618371475458562e-19 0.9720727966840245 0.08385586621601075 0.10739443716057426 0.30876900068828367 0.05797254064026173 0.11011698042921353 1.1203952694534689e-07 6.950628733528041 -1.067158168146552 down TLPGWNTDISNAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLPGWNTDISNAR 13 0 P30520 P30520 ADSS Adenylosuccinate synthetase isozyme 2 0 10530000.0 3034200.0 3358200.0 4137600.0 False True 2937880.9818371097 4699146.772781651 3053838.4346606857 1.0 1.5995020907358848 1.0394697584893537 21.48634452056507 -10.140198156556984 4.791133515313256 0.9999757324294565 1.3194859246147312 0.3026140982425872 0.2286322422514048 159781208.74623257 0.33133481756608557 42776.422279166654 0.07826689778270463 7.241054953851959e-11 10.140198156556984 0.31951019218527477 TLPHGAGHLAFSQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLPHGAGHLAFSQR 14 0 O15213 O15213 WDR46 WD repeat-containing protein 46 0 4860700.0 1323800.0 1388100.0 2148800.0 False True 1735514.619697434 1181000.8907714204 1926462.7887450687 1.0 0.6804903153033155 1.1100239472951974 20.72693208757408 -6.707506593683553 1.8039134762589255 0.8030776806747298 1.1089508202099465 0.4533488591614807 0.1346929400988423 0.38010195263191887 2.40948483048693 0.05945237897881188 0.15150557467950035 1.9610714012492386e-07 6.707506593683553 0.30587313953521666 TLPHGAGHLAFSQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLPHGAGHLAFSQR 14 0 O15213 O15213 WDR46 WD repeat-containing protein 46 0 3691270.0 1323800.0 866770.0 1500700.0 False True 1813244.6343498537 828473.2353749108 1146265.5678866692 1.0 0.45690097170587424 0.6321626691578036 20.790142149096972 -10.667447353759892 6.978422057519501 1.00217653331618 0.54453182043184 0.9000493684557967 0.07155028836854495 0.0024315022971511326 0.0001158716754488389 0.06952418348500927 0.023092756272309414 2.1505653603366092e-11 10.667447353759892 -0.45764471288434005 TLPHGAGHLAFSQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLPHGAGHLAFSQR 14 0 O15213 O15213 WDR46 WD repeat-containing protein 46 0 5851160.0 890960.0 2728400.0 2231800.0 False True 1153365.2834472249 2576562.141543641 1825635.3002018104 1.0 2.2339515316801526 1.5828769310146718 20.13741807204226 -10.292923750598824 8.65305835733847 0.9999993083641084 1.9084142313474122 0.7218856859332806 0.26580009268612487 3.54661550055124e-06 2.898475622131539e-07 0.257360028632371 0.0857866110328125 5.0942030250287175e-11 10.292923750598824 0.9084149229833037 TLPLFYGSIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLPLFYGSIVR 11 0 A6NHR9-2;A6NHR9;J3KTL8 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 0 14542900.0 5027600.0 4365400.0 5149900.0 False True 6591232.287347653 3714099.336195921 4617037.749329038 1.0 0.5634908882403376 0.700481722999169 22.652116783972705 -10.83794428291294 10.73487310803782 1.006702185137945 0.6319863056197547 0.9058593674036721 0.05592627409951049 0.008890293313497732 0.00013420931269000384 0.05366439399846204 0.01805012735023628 1.452297925779428e-11 10.83794428291294 -0.3747158795181903 TLPLFYGSIVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLPLFYGSIVR 11 0 A6NHR9-2;A6NHR9;J3KTL8 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 0 12234100.0 5027600.0 2962200.0 4244300.0 False True 6886439.585781333 2831320.2093145344 3241883.75410234 1.0 0.41114427478031723 0.47076340592546084 22.715326845495596 -10.119707716815153 5.75658292581264 1.0000047859933312 0.44095384035875906 0.9915423732608644 0.02433940836908898 1.4950514220115947e-06 2.2855155200443608e-07 0.023566732467643473 0.007855510272481036 7.590882748076343e-11 10.119707716815153 -0.5590509456345721 TLPLFYGSIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLPLFYGSIVR 11 0 A6NHR9-2;A6NHR9;J3KTL8 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 0 7779600.0 4474300.0 1959100.0 1346200.0 False True 3720578.6950982907 1948545.9394490952 1627684.1958744687 1.0 0.5237212001499186 0.4374814590049864 21.827095603457717 -13.999999999999998 0.24034593312938096 4.157802477666951 0.39947578001186257 0.9995255357155038 0.005388155524222441 13.635645035403096 0.15516355198349827 20.67038338952862 0.042054508226967664 1.0000000000000041e-14 13.999999999999998 -3.758326697655088 TLPLTGSTFHDQIAMLSHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLPLTGSTFHDQIAMLSHR 19 0 P55265;P55265-4;P55265-5 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 10546100.0 2403300.0 3983600.0 4159200.0 False True 3150749.573590309 3389262.407951179 3728845.881863597 1.0 1.0757003464699615 1.1834789769135925 21.587263660621268 -6.966109659547854 0.33846685333415927 0.9881002857113343 1.2746525180661394 0.9999342204469263 0.0006105736130932208 0.07758636898076267 0.013543193650901574 0.0015286833037675626 0.009339257812239406 1.0811609232205011e-07 6.966109659547854 0.2865522323548051 TLPLTGSTFHDQIAMLSHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLPLTGSTFHDQIAMLSHR 19 0 P55265;P55265-4;P55265-5 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 9557100.0 3895800.0 1890700.0 3770600.0 False True 3772129.9614531053 2645666.36987025 2782966.7444246868 1.0 0.7013720091582112 0.7377706422799464 21.846947951464962 -10.203536231487737 8.042174450065739 1.0000001102863871 0.7195713258483843 0.9875223280089258 0.014859679747169733 2.939561508168779e-08 2.905818991608759e-09 0.01438782883630452 0.004795941015897005 6.258406503090942e-11 10.203536231487737 -0.2804287844380028 TLPLTGSTFHDQIAMLSHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLPLTGSTFHDQIAMLSHR 19 0 P55265;P55265-4;P55265-5 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 10503400.0 2403300.0 3158300.0 4941800.0 False True 3291864.9567404534 3018755.8628985514 3774648.619565766 1.0 0.9170351465108916 1.1466596197504275 21.65047372214416 -6.808943932296233 1.4187818706426618 0.9547285419860375 1.1505879071031788 0.8571106276226911 0.035887369890645796 0.20823520987726693 0.8263075383843191 0.019889605388170428 0.04603511993914819 1.5525874370812812e-07 6.808943932296233 0.1958593651171413 TLPLTGSTFHDQIAMLSHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLPLTGSTFHDQIAMLSHR 19 0 P55265;P55265-4;P55265-5 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 9387500.0 3895800.0 2436500.0 3055200.0 False True 3239530.3132029437 2423374.090892617 3694028.194351268 1.0 0.74806340938252 1.1402974620413289 21.62735322689924 -6.733204951821726 1.7112023270060883 0.8489359925166953 1.1402204598817478 0.5742562368154188 0.10588386644016536 0.33023881626571594 1.8958026223037543 0.04900306210385055 0.12117495015179466 1.848396119853786e-07 6.733204951821726 0.29128446736505254 TLPLTGSTFHDQIAMLSHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLPLTGSTFHDQIAMLSHR 19 0 P55265;P55265-4;P55265-5 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 14883900.0 3597700.0 6548000.0 4738200.0 False True 4657293.571269287 6183598.043845401 3875896.218037558 1.0 1.3277234834393614 0.8322207219119389 22.151060394249303 -6.7283805502263165 1.729291848317142 1.197583340511047 0.8326118505820489 0.5516241904145558 0.13778609027820599 0.33930672671378653 1.98712945729997 0.06316283517983173 0.15701307625117092 1.8690436744475916e-07 6.7283805502263165 -0.3649714899289981 TLQEDLVK(ub)DVLSNAHIQNELER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLQEDLVKDVLSNAHIQNELER 22 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 60144700.0 2887300.0 8521400.0 48736000.0 True False 4380245.189904366 7000689.591997914 39103308.238252416 1.0 1.5982414884292724 8.927196205449441 22.062580198136594 -6.923097083932183 0.8014184455348345 0.8556221606722454 10.197573619825913 0.9949989449143871 0.2548818682333303 0.09638361222165437 0.0964203636147947 0.22328868832507232 0.6900157602357185 1.193721225400242e-07 6.923097083932183 9.341951459153668 up TLQEDLVK(ub)DVLSNAHIQNELER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLQEDLVKDVLSNAHIQNELER 22 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 84909200.0 2887300.0 6875900.0 75146000.0 True False 3737666.7671917654 6493250.120598133 61470199.06307257 1.0 1.7372469310517829 16.446142176889996 21.833706520229043 -6.917313783112344 0.844417270160752 0.6429873320932363 18.677423151119562 0.9934014879934969 0.5778773378400998 0.09977806746430537 0.11399707849275333 0.49094420425665863 1.434864334237656 1.2097237773927392e-07 6.917313783112344 18.034435819026324 up TLQFEISDSHEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLQFEISDSHEK 12 0 Q96IX9 Q96IX9 ANKRD36BP1 Putative ankyrin repeat domain-containing protein 26-like 1 0 5078900.0 1016100.0 1067100.0 2995700.0 False True 1332116.9399263978 907892.8395232223 2685733.700783512 1.0 0.6815413964883483 2.0161395897659737 20.34528930432091 -6.84374117504799 1.2649344734854955 0.83058278751572 2.0633805187469805 0.9306927522972132 0.1498288297522201 0.16447471672606365 0.5095884113954358 0.09281708483173591 0.21409306691302626 1.4330416896390674e-07 6.84374117504799 1.2327977312312606 up TLQFEISDSHEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLQFEISDSHEK 12 0 Q96IX9 Q96IX9 ANKRD36BP1 Putative ankyrin repeat domain-containing protein 26-like 1 0 5753200.0 1322600.0 1464000.0 2966600.0 False True 1280614.786954637 2048582.8346591408 2189558.463907672 1.0 1.5996870062157946 1.709771342805237 20.28840514295316 -11.439260967083175 0.29607780648276266 4.142170852800361e-09 1.7420837180018234 0.9993536875083829 0.007929258024241555 3.774916535255829 0.15783272282095734 2.468698778287156 0.040367870782702625 3.6369642566464377e-12 11.439260967083175 1.7420837138596525 TLQFEISDSHEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLQFEISDSHEK 12 0 Q96IX9 Q96IX9 ANKRD36BP1 Putative ankyrin repeat domain-containing protein 26-like 1 0 5652400.0 1016100.0 2642500.0 1993800.0 False True 1391779.6290700175 2525745.612421058 1522905.503599947 1.0 1.8147597217734484 1.0942145378414163 20.408499365843802 -10.25163539923495 4.454188739808903 0.9997890573433167 1.45448712981255 0.3466052393127438 0.29416133955957735 0.0006164811078839299 0.00010357752090447289 0.28495131895854053 0.09494016409859338 5.602277289101974e-11 10.25163539923495 0.4546980724692332 TLQFEISDSHEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLQFEISDSHEK 12 0 Q96IX9 Q96IX9 ANKRD36BP1 Putative ankyrin repeat domain-containing protein 26-like 1 0 5310000.0 1322600.0 1102800.0 2884600.0 False True 1099800.5011145878 1096858.9975113382 3487756.5231165416 1.0 0.9973254207465185 3.171262896845283 20.068810418387436 -6.9066184757302045 0.918453859833425 0.9252826930132356 3.43279912164328 0.9895817140977695 0.10453745850516374 0.10669685380279338 0.1512107088553607 0.08418027815434136 0.22727598473992305 1.2398853377001217e-07 6.9066184757302045 2.507516428630044 up TLQFEISDSHEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLQFEISDSHEK 12 0 Q96IX9 Q96IX9 ANKRD36BP1 Putative ankyrin repeat domain-containing protein 26-like 1 0 27417400.0 2086100.0 6182300.0 19149000.0 False True 2700497.573178663 5838249.570321532 15664078.485332243 1.0 2.161916243994076 5.8004416078384375 21.364793821126508 -6.950482432090381 0.5535215297339398 0.9506990472424213 7.183627266855062 0.9992386038152705 0.05642471971530761 0.08329259039412919 0.035165046230628265 0.06096864635669052 0.30205254173988255 1.1207727622787768e-07 6.950482432090381 6.23292821961264 TLQIFNIEMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLQIFNIEMK 10 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13;J3KSQ2;F5H5N6;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 17340100.0 5476500.0 4647700.0 7215900.0 False True 7179744.534501434 3954281.27659271 6469267.887800414 1.0 0.5507551497954931 0.9010442999347809 22.775501081149 -9.830824297413793 6.304244384045024 1.000000011671861 0.7258997248650475 0.44946121847033904 0.14300494671272493 2.3401396350762507e-08 4.254682394099776e-09 0.138463948387317 0.04615464808692463 1.4763036808838838e-10 9.830824297413793 -0.27410028680681353 TLQIFNIEMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLQIFNIEMK 10 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13;J3KSQ2;F5H5N6;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 9031600.0 2841900.0 2689800.0 3499900.0 False True 2751685.440077409 3763851.1671216995 2583171.195250608 1.0 1.3678348230878514 0.938759626237634 21.391884126581353 -6.6797869069047415 1.9028888236229313 1.2327802032582587 0.9404047080286401 0.3230674696298065 0.15590467516236572 0.4389808733119652 3.07311162628523 0.06575017150824644 0.1734434945377412 2.090321526850214e-07 6.6797869069047415 -0.2923754952296186 TLQIFNIEMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLQIFNIEMK 10 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13;J3KSQ2;F5H5N6;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 18925100.0 2783700.0 9331100.0 6810300.0 False True 4223076.415729845 7665892.300782933 5464241.219939477 1.0 1.8152388321057862 1.2939006264690405 22.009862921980098 -10.282905008964644 4.301261289097566 0.9995459631803294 1.554569729297005 0.6013921738739307 0.21283543124421164 150834794.92977852 514.2877495647228 682109.6157631322 0.0728592291997009 5.213087218560699e-11 10.282905008964644 0.5550237661166757 TLQIFNIEMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLQIFNIEMK 10 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13;J3KSQ2;F5H5N6;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 19475700.0 5476500.0 5268600.0 8730600.0 False True 7501310.046847694 5035815.831069666 6668612.092351135 1.0 0.6713248485424073 0.8889929959838833 22.83871114267189 -10.392114368704133 5.000875916499596 1.000200515629908 0.780158922263117 0.5762867906643003 0.08886264908151656 0.00019884236014522958 2.417050851696381e-05 0.0861189053563499 0.028680296666034947 4.054017614008797e-11 10.392114368704133 -0.22004159336679108 TLQIFNIEMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLQIFNIEMK 10 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13;J3KSQ2;F5H5N6;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 8798600.0 2841900.0 2476100.0 3480600.0 False True 2363165.7675166684 2462760.757832631 4208377.367523898 1.0 1.0421447330039069 1.7808219065166426 21.17228940201563 -6.918634753826686 0.8347712686438564 0.9828871108486156 1.8962858168417271 0.9937938475818322 0.028247236347879547 0.09898104783073793 0.10981867469942871 0.024163825765466336 0.0714658492352034 1.206049814402267e-07 6.918634753826686 0.9133987059931116 TLQIFNIEMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLQIFNIEMK 10 0 A0A087WVQ6;Q00610-2;Q00610;J3KS13;J3KSQ2;F5H5N6;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 11865500.0 2783700.0 6014200.0 3067600.0 False True 3603554.524930459 5679504.483093316 2509328.27623402 1.0 1.5760839592687774 0.6963480804504949 21.780989244072547 -6.7300302044002915 1.7230893243567211 1.3466725776494681 0.6968657621576163 0.5594178969991264 0.2421713894744269 0.3361824224456997 1.9554544201291368 0.11137495468708766 0.2763631715754958 1.861957636354126e-07 6.7300302044002915 -0.6498068154918518 TLQLALDLVSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLQLALDLVSSR 12 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 50876100.0 16836100.0 19353000.0 14687000.0 False True 25541594.5837803 15899305.944320826 11784108.012459224 1.0 0.6224868182042704 0.461369315600307 24.606345260759596 -13.999999999999998 0.11630381532030157 2.805368640338558 0.19092594614659522 0.999711254209611 0.003835766781193315 11.979438192348963 0.10446083402276123 5.025027887282376 0.23998217259680216 1.0000000000000041e-14 13.999999999999998 -2.6144426941919625 TLQLALDLVSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLQLALDLVSSR 12 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 63768500.0 16836100.0 25426200.0 21506200.0 False True 21794663.339146346 24011209.618573878 17592292.272246715 1.0 1.1017013314193431 0.8071834833368786 24.377471582852046 -6.813447221947956 1.3998468516247664 1.055204912809515 0.8016069496050312 0.8686784238376077 0.04426123790884505 0.20213207698923194 0.7799590691139906 0.024856474926852692 0.05741765454593514 1.536571515307751e-07 6.813447221947956 -0.2535979632044837 TLQLDNNFEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLQLDNNFEVK 11 0 Q9UMS4 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 18552900.0 6957700.0 4211000.0 7384200.0 False True 6736831.6219524285 5892474.260074897 5450056.498748414 1.0 0.8746655090612425 0.8089940204218599 22.683638810877376 -13.999999999724805 0.08142659112516902 1.670145449233976 0.6179571792953973 0.9998807157157243 0.0008653727700979083 12.244473043115407 0.0807008673729906 1.468548993763243 0.17319206212947583 1.0000000006336598e-14 13.999999999724805 -1.0521882699385787 TLQLDNNFEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLQLDNNFEVK 11 0 Q9UMS4 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 26636000.0 6390600.0 9988400.0 10257000.0 False True 8272757.67755886 9432536.759490741 8390331.245707488 1.0 1.1401925605868963 1.0142121373224269 22.97993689322635 -10.749765266124538 2.789675655801902 0.9845287689844351 1.0772023489423201 0.33365249075905756 0.05143129323963495 18249715.213332392 18336542.472700752 1971793.194164258 0.019999410041635742 1.7792408204703363e-11 10.749765266124538 0.09267357995788505 TLQQNAESR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLQQNAESR 9 0 O95816;O95816-2 O95816 BAG2 BAG family molecular chaperone regulator 2 0 4368990.0 715090.0 1983200.0 1670700.0 False True 937489.9149414102 1687314.2904530524 1497831.990486033 1.0 1.7998212712064252 1.597704643659705 19.8384436452076 -10.056515952982236 4.660897842995874 0.9999756866529815 1.6987629571293703 0.940956108903736 0.08251376777156383 57189427.74606967 0.8505604617455486 17172.988556955657 0.02824665743031198 8.779788356206207e-11 10.056515952982236 0.6987872704763888 TLQQNAESR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLQQNAESR 9 0 O95816;O95816-2 O95816 BAG2 BAG family molecular chaperone regulator 2 0 3392650.0 1425100.0 732550.0 1235000.0 False True 1379860.9805602997 1025061.0351977834 911516.4507941663 1.0 0.7428726876395563 0.6605857138043285 20.396091493748536 -13.999999999999998 0.15940758301865662 2.264743239419546 0.5791624682051578 0.9995379371436903 0.0031074823832695385 12.005788595527243 0.1261514329942896 4.694986731094871 0.07415518814591256 1.0000000000000041e-14 13.999999999999998 -1.6855807712143882 TLQQNAESR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLQQNAESR 9 0 O95816;O95816-2 O95816 BAG2 BAG family molecular chaperone regulator 2 0 4755590.0 715090.0 2080400.0 1960100.0 False True 979478.0975806298 1988481.0490371864 1497164.7495266616 1.0 2.0301434549163018 1.5285331578365553 19.901653706730492 -10.158732308230759 4.79520185659856 0.99992803371224 1.7793383063800043 0.7629507408486947 0.204781546276046 26124484.204438828 55345273.19816813 13059.775371900103 0.07010216700146679 6.938533537018533e-11 10.158732308230759 0.7794102726677643 TLQQQTFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLQQQTFK 8 0 P54727;Q5W0S5;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 0 12699600.0 2922000.0 6644000.0 3133600.0 False True 3830770.29668825 5652741.098109153 2809365.1316137128 1.0 1.475614735500069 0.7333682037898344 21.869203089796457 -6.7336511045710505 1.709954154512635 1.285055991783281 0.7335110261813959 0.5760691147444907 0.19988654001489292 0.32944725192250957 1.8887645704753364 0.09257467793876092 0.22877117103732358 1.8464982289112595e-07 6.7336511045710505 -0.551544965601885 TLQQQTFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLQQQTFK 8 0 P54727;Q5W0S5;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 0 12382900.0 3827800.0 3102600.0 5452500.0 False True 3706288.5842317906 4341484.35984526 4024326.678506232 1.0 1.1713832480060717 1.0858103968556354 21.82154378820443 -10.227368140152544 5.506145359922304 0.9999928384534285 1.1285968224308618 0.7506926991221164 0.0349349701923128 3.071398980159186e-06 4.310258089320264e-07 0.03382752286747624 0.011275213146252528 5.92422930145617e-11 10.227368140152544 0.12860398397743333 TLQQQTFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLQQQTFK 8 0 P54727;Q5W0S5;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 0 11695500.0 2922000.0 3739700.0 5033800.0 False True 4002342.3640808854 3574467.6884658597 3844920.1143652415 1.0 0.8930939343283081 0.9606674703472563 21.93241315131935 -10.024353707835958 4.717242723753454 1.0000016067667068 0.9268807024291503 0.6095530360457307 0.02758678056905169 5.299952972485225e-07 1.0960980336438052e-07 0.02671145271510973 0.008903595142046843 9.454668194523859e-11 10.024353707835958 -0.07312090433755647 TLQQQTFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLQQQTFK 8 0 P54727;Q5W0S5;P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54727;P54725-3 RAD23B;RAD23A UV excision repair protein RAD23 homolog B;UV excision repair protein RAD23 homolog A 0 8699000.0 3827800.0 3692200.0 1179000.0 False True 3182985.3002921706 3672309.385755679 1425523.4489199216 1.0 1.1537311797885441 0.44785737740889686 21.601949063638706 -6.849659158778734 1.2367581197870559 1.0820106330136363 0.41982723953158657 0.9398095685501011 0.07435843670452184 0.1578274992673965 0.46472641849377255 0.047051639171464675 0.10885531267365348 1.413646561698744e-07 6.849659158778734 -0.6621833934820498 down TLQQQTFK(ub)IR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLQQQTFKIR 10 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 69913000.0 42901000.0 15689000.0 11323000.0 True False 65083953.483215235 12889175.371283516 9085004.086952802 1.0 0.1980392198302391 0.1395890016007674 25.955798553473244 -13.716590419652668 0.3742373117944364 9.998904173119506 0.13385517826439014 0.9997911855261628 0.005672517599790183 18.747121773676227 0.1984839580293928 134.39351247870698 0.016128870995436365 1.920479078409049e-14 13.716590419652668 -9.865048994855115 TLQQQTFK(ub)IR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLQQQTFKIR 10 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 23036900.0 10188000.0 10614000.0 2234900.0 True False 13954778.920347732 10145038.38419568 1707062.649210313 1.0 0.7269938450549728 0.12232817581375025 23.734255932790045 -7.2630280511120695 0.587666544604141 1.0022468249183014 1.0280304050385597e-22 0.9974642535539661 0.01846745268792135 0.09518506864100537 0.06054501968114886 0.017976144516703145 0.057069138152207696 5.457226116898523e-08 7.2630280511120695 -1.0022468249183014 down TLQQQTFK(ub)IR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLQQQTFKIR 10 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 33934200.0 14574000.0 16274000.0 3086200.0 True False 12118926.737671252 16186328.731863929 3731510.151023459 1.0 1.3356239444495777 0.3079076416415814 23.530758602395288 -6.818736926603408 1.3772535952359568 1.181132023063182 0.2860583091740211 0.8814795801110623 0.1473100365844847 0.19512083563689103 0.7275749484456793 0.08405760698471776 0.19381479555919598 1.517969597405535e-07 6.818736926603408 -0.895073713889161 down TLQQQTFK(ub)IR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLQQQTFKIR 10 1 P54725-3;P54725;P54725-2;A0A494C0B4;K7ENJ0;K7ELW1 P54725-3 RAD23A UV excision repair protein RAD23 homolog A 1 71460700.0 42901000.0 20815000.0 7744700.0 True False 55536190.205137685 19656626.952144448 6335244.06733264 1.0 0.3539426611645032 0.1140741567603347 25.726924875565693 -9.839995555123256 0.26495870470184196 1.4921435208272247 7.24298209316218e-26 0.9989670570680056 0.012024477410603739 1.272940917482305 0.11700768518218962 0.5834842088814702 0.09794894231612644 1.4454545644740725e-10 9.839995555123256 -1.4921435208272247 TLQTISLLGYMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLQTISLLGYMK 12 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 11367800.0 2688700.0 6000400.0 2678700.0 False True 3524911.7374078403 5105163.709376004 2401533.819904793 1.0 1.44830965700442 0.6813032492186144 21.749155702694267 -6.748275367310275 1.6562209725923782 1.264154894543599 0.6799761877844763 0.6415269511696576 0.18836872746313274 0.3030590557323508 1.6350626377759283 0.08986579245884638 0.2185669299026855 1.7853551995335274e-07 6.748275367310275 -0.5841787067591226 TLQTISLLGYMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLQTISLLGYMK 12 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 8246000.0 4028700.0 1605300.0 2612000.0 False True 3900811.1236988907 2246304.6615289105 1927838.841679647 1.0 0.5758557875006476 0.4942148646898854 21.895342714443938 -13.999999999999998 0.23168219657717407 3.6985099102453267 0.45515039114968264 0.9995121364857542 0.004896958393794544 13.344220792263199 0.15239257534606154 16.58052465284204 0.041939851426375616 1.0000000000000041e-14 13.999999999999998 -3.243359519095644 TLQTISLLGYMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLQTISLLGYMK 12 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 9265300.0 2688700.0 2649100.0 3927500.0 False True 3682785.0493854512 2532054.0025977776 2999905.3894015364 1.0 0.6875378195152343 0.814575205767747 21.81236576421716 -10.049529569841978 4.923700049206227 1.000005203187446 0.7510565129132896 0.8366035762642907 0.0518627957708227 71841176.94276525 5.24860593446387 4237.9364028971895 0.01775401446060483 8.922168690807188e-11 10.049529569841978 -0.24894869027415645 TLQTISLLGYMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLQTISLLGYMK 12 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 7841800.0 4028700.0 1308900.0 2504200.0 False True 3350042.5516712125 1301848.6959036915 3027816.64188742 1.0 0.38860661493814375 0.9038143830074499 21.675747989878214 -10.234151546734147 7.915344769855536 1.0000003067541114 0.6462104989728111 0.386024491876222 0.21033269054799664 1.1386563102022671e-06 1.1003360431070334e-07 0.20365392791881537 0.06788458397128241 5.832415470592793e-11 10.234151546734147 -0.3537898077813003 TLQTISLLGYMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLQTISLLGYMK 12 0 O60264 O60264 SMARCA5 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5 0 8706100.0 1254600.0 3338300.0 4113200.0 False True 1624104.43186326 3152520.67039846 3364639.804996008 1.0 1.941082487399975 2.071689319347471 20.631212971851706 -10.901644689392489 0.37032259463696976 1.1204096773545404e-24 2.088835243147046 0.9993903840421582 0.01178724124709889 2.636052688687877 0.18207866186030106 2.3225392826385054 0.03635379468145686 1.2541668304793676e-11 10.901644689392489 2.088835243147046 TLQYK(ub)LLEPVLLLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLQYKLLEPVLLLGK 15 1 P62249;M0R3H0;M0R1M5;Q6IPX4 P62249 RPS16 40S ribosomal protein S16 1 2231920.0 466290.0 602830.0 1162800.0 True False 611310.7055587837 512890.11381293554 1042484.6103652127 1.0 0.8390007064314629 1.7053269325821863 19.22154630691063 -6.8586911156671 1.1923164372653028 0.9129328968247197 1.7462449033499112 0.9520305117401487 0.08240123597334399 0.1481573117458935 0.4009683860718481 0.053930122360184025 0.12571058788531866 1.3845507663142356e-07 6.8586911156671 0.8333120065251916 TLQYK(ub)LLEPVLLLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLQYKLLEPVLLLGK 15 1 P62249;M0R3H0;M0R1M5;Q6IPX4 P62249 RPS16 40S ribosomal protein S16 1 8218800.0 2058500.0 2715600.0 3444700.0 True False 1993154.0442659308 3799953.24166692 2542429.731215115 1.0 1.9065025368204418 1.275581151657287 20.92662178492526 -10.261815077563835 5.714907343337313 0.9999642760374556 1.5910418442388725 0.5391927255401091 0.25757257690997903 0.00011724556250317542 1.5144100183129541e-05 0.24940859325433123 0.08313119173433563 5.472489316922082e-11 10.261815077563835 0.5910775682014169 TLQYK(ub)LLEPVLLLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLQYKLLEPVLLLGK 15 1 P62249;M0R3H0;M0R1M5;Q6IPX4 P62249 RPS16 40S ribosomal protein S16 1 47184300.0 1369200.0 3498100.0 42317000.0 True False 2077176.501928119 2873836.7242199555 33953026.4018 1.0 1.3835303459057737 16.34575895225246 20.98619237945836 -6.912403943074778 0.8791978956542633 0.5712142264081742 18.382246789398163 0.9917977171167295 0.6471314590393896 0.10284991470615323 0.1303008483340458 0.5361945535492374 1.506006543039953 1.2234776969979055e-07 6.912403943074778 17.81103256298999 up TLQYK(ub)LLEPVLLLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLQYKLLEPVLLLGK 15 1 P62249;M0R3H0;M0R1M5;Q6IPX4 P62249 RPS16 40S ribosomal protein S16 1 43837500.0 1369200.0 4568300.0 37900000.0 True False 1772456.3909669814 4314070.089141557 31002588.88683966 1.0 2.4339499189528566 17.49131264658415 20.75731870155081 -6.9254106738868835 0.7835420634216697 0.7279485053291693 20.249838453681658 0.9955569095934054 0.49719768856442664 0.09509173543380277 0.08987306673738048 0.441162591691283 1.3983822915884174 1.1873788971805085e-07 6.9254106738868835 19.521889948352488 TLSDLKLDYLDLYLIHWPTGFKPGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLSDLKLDYLDLYLIHWPTGFKPGK 25 2 P15121;E9PCX2 P15121 AKR1B1 Aldose reductase 0 652686000.0 141895000.0 207011000.0 303780000.0 False True 215265088.91403052 170068269.66567478 243737749.8484961 1.0 0.7900411094229691 1.1322678985157533 27.68153912535513 -6.740685523068821 1.6840809090560505 0.8751761049268004 1.1325031457016228 0.6080720598545539 0.08821453171349655 0.3165719830146322 1.7631551108841763 0.04143361254450127 0.10160210532279054 1.8168307717111735e-07 6.740685523068821 0.2573270407748224 TLSDLKLDYLDLYLIHWPTGFKPGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLSDLKLDYLDLYLIHWPTGFKPGK 25 2 P15121;E9PCX2 P15121 AKR1B1 Aldose reductase 0 63540200.0 41131000.0 15998000.0 6411200.0 False True 34202248.912251696 15911815.598645614 7751752.277960465 1.0 0.465227173788148 0.22664451971705538 25.02758785446547 -10.171136621789705 0.18958917385182708 1.6957061101655309 7.53829532043453e-24 0.9994782452334627 0.007385885415495916 1.7538640459408947 0.09046810806815783 0.7581274325736546 0.1529135605829339 6.743158658205276e-11 10.171136621789705 -1.6957061101655309 TLSDLKLDYLDLYLIHWPTGFKPGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLSDLKLDYLDLYLIHWPTGFKPGK 25 2 P15121;E9PCX2 P15121 AKR1B1 Aldose reductase 0 383809000.0 141895000.0 110681000.0 131233000.0 False True 183685874.66860938 104521505.05358167 107349940.56429094 1.0 0.5690230957723373 0.5844213157814268 27.45266544744758 -9.765214902864274 6.274350852978619 1.0000000075709448 0.5767222057900065 0.999008435760293 0.006286296996349224 6.59442907988943e-10 1.3009912108304694e-10 0.006086680984101467 0.0020288936311343097 1.7170585211761108e-10 9.765214902864274 -0.4232778017809382 TLSDYNIQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLSDYNIQK 9 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 95916000.0 18389000.0 42316000.0 35211000.0 False True 24108157.07932929 36002617.74647613 31567703.48776186 1.0 1.4933790927281345 1.3094200184562634 24.523018034184194 -10.142140445475967 4.4859964112364175 0.9999441374627704 1.4013995556035008 0.8639121089072007 0.07510097762952576 52494885.75055482 3.346503539520292 30861.188241976313 0.02570906220510238 7.208743196255683e-11 10.142140445475967 0.4014554181407304 TLSDYNIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLSDYNIQK 9 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 66044000.0 17878000.0 16704000.0 31462000.0 False True 17310472.675922424 23373994.310209215 23221158.360231627 1.0 1.350280535246198 1.34145143202996 24.04514178336432 -10.06374482953878 4.430296327799405 0.9999755592251348 1.3458659836680187 0.9995114964965693 0.003604466397194658 1250006.8165773635 0.003933815517507447 313.7481432276361 0.0012339047056617808 8.634857412665369e-11 10.06374482953878 0.34589042444288387 TLSDYNIQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLSDYNIQK 9 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 246098000.0 27181000.0 182630000.0 36287000.0 False True 41235564.197274454 150038249.60529718 29114858.544842873 1.0 3.638564247296373 0.7060618451964161 25.297385811301965 -6.669569034366262 1.9387404562146264 2.684716305292597 0.7178378415225689 0.27737245362363716 1.1208959478393299 0.46199544046541324 3.34736823699006 0.46550275392084245 1.244478608702537 2.140084717210788e-07 6.669569034366262 -1.966878463770028 TLSDYNIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLSDYNIQK 9 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 86805000.0 18389000.0 25750000.0 42666000.0 False True 25187910.244039476 24612279.85613705 32589169.53385258 1.0 0.9771465603011411 1.2938417366944746 24.586228095707085 -6.889552637161855 1.0250043668352273 0.9828006947725068 1.320845059780573 0.9806111648261472 0.020079937610823335 0.11950771720520394 0.22396343714893002 0.014935054128765404 0.037174626295850374 1.289577249672485e-07 6.889552637161855 0.3380443650080662 TLSDYNIQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLSDYNIQK 9 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 46897000.0 17878000.0 15951000.0 13068000.0 False True 14866349.129688945 15865068.796974385 15800458.380394857 1.0 1.067179887850941 1.0628338028763527 23.825547058798595 -10.317295937833565 7.316864252504366 0.9999993427870045 1.065006845363647 0.9966588909436381 0.001774281761086411 1.902129388763895e-08 1.7756124281450174e-09 0.0017179583099496375 0.0005726469760139308 4.8161949963920436e-11 10.317295937833565 0.06500750257664245 TLSDYNIQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLSDYNIQK 9 0 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 0 91321000.0 27181000.0 32242000.0 31898000.0 False True 35186340.31761138 30447704.357004188 26092891.30111903 1.0 0.8653273992738761 0.7415630914039412 25.068512133394414 -6.97213680555838 0.2007060434586975 1.0729997112880394 0.530471103126002 0.9999945984541874 0.0002452147096951679 0.07561537249423989 0.006486152049701726 0.003994971908155558 0.013115715647005545 1.0662601894969767e-07 6.97213680555838 -0.5425286081620374 TLSDYNIQK(ub)ESTLHLVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLSDYNIQKESTLHLVLR 18 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 9299625570.0 2456210500.0 3316206370.0 3527208700.0 True False 3220115751.476319 2821441306.0671873 3162246979.0989733 1.0 0.8761925110218934 0.9820289775760965 31.58446540290982 -10.115316316596063 4.889768928945106 1.0000033471997427 0.929110744298615 0.3742866400732767 0.04320755654080178 1.5767143288522648e-06 2.8522272143640586e-07 0.041837512306639596 0.01394517890921627 7.668027882720387e-11 10.115316316596063 -0.07089260290112775 TLSDYNIQK(ub)ESTLHLVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLSDYNIQKESTLHLVLR 18 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 15633634860.0 4960237700.0 4620864300.0 6052532860.0 True False 4802777669.310355 6465999512.4789915 4467192931.872271 1.0 1.3463041509909126 0.9301269472492004 32.161221878716596 -6.685865327501687 1.8813646396987154 1.217948390083359 0.9316421647007496 0.35106182448361356 0.14658768361249755 0.42559926938288184 2.917402915423625 0.0624115779105401 0.1633607923784425 2.0612690031543437e-07 6.685865327501687 -0.2863062253826094 TLSDYNIQK(ub)ESTLHLVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLSDYNIQKESTLHLVLR 18 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 41344630800.0 9325547300.0 12391442300.0 19627641200.0 True False 14147537042.929573 10180092606.784428 15748229313.719234 1.0 0.7195664217661172 1.113142822381909 33.719831863751864 -6.715368403928401 1.7758475117414803 0.828549344093625 1.1123808534311626 0.4906164804078552 0.11807950959543954 0.3644052318851356 2.2432611055778096 0.052846970211330585 0.1334005339516996 1.9258905229805227e-07 6.715368403928401 0.28383150933753754 TLSDYNIQK(ub)ESTLHLVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLSDYNIQKESTLHLVLR 18 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 11264866770.0 2456210500.0 3843200600.0 4965455670.0 True False 3364337898.442951 3673395289.7271442 3792717307.515579 1.0 1.0918627678353081 1.1273294841373949 31.647675464432712 -13.999999998234708 0.1317461205163016 0.5632937907603944 1.175914087949173 0.9996377727170311 0.001021154634777084 11.934317629952183 0.11304255454664715 1.347552470829594 0.04323738873017339 1.0000000040647349e-14 13.999999998234708 0.6126202971887785 TLSDYNIQK(ub)ESTLHLVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLSDYNIQKESTLHLVLR 18 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 14822938560.0 4960237700.0 4182790260.0 5679910600.0 True False 4124657423.3384886 4160256738.650516 6867553645.520628 1.0 1.0086308538281499 1.664999766201685 31.941627154150872 -6.909767474866131 0.8973207965726968 0.979527599001784 1.749402715252181 0.9908333796504303 0.02982085981145254 0.1045720371640523 0.13960448428049635 0.024386670795998856 0.06720994914709048 1.2309276440378277e-07 6.909767474866131 0.769875116250397 TLSDYNIQK(ub)ESTLHLVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLSDYNIQKESTLHLVLR 18 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;M0R1M6;A0A2R8Y422;M0R2S1 P62979;A0A2R8Y422;M0R2S1 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 24996039600.0 9325547300.0 12305249700.0 3365242600.0 True False 12072104813.869354 11620451737.011152 2752802977.1049967 1.0 0.9625870480896331 0.2280300759104052 33.49095818584432 -6.9174708704408605 0.8432845756553279 1.017732336068573 0.11620810701911868 0.9934486077306057 0.02876794357515901 0.09968330044879714 0.11349908051572646 0.024459964104459546 0.07158641129139087 1.2092862910315317e-07 6.9174708704408605 -0.9015242290494544 down TLSEK(ub)ETEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLSEKETEAR 10 1 P12270 P12270 TPR Nucleoprotein TPR 1 2797170.0 816580.0 1237400.0 743190.0 True False 1070544.2877719682 1052784.7433474227 666291.8279818726 1.0 0.9834107335610497 0.6223860475390219 20.029913049706494 -6.916501806254124 0.8502614997109301 1.0090136025595553 0.5686062401245061 0.9931528482476183 0.014417138209918365 0.10027418044029422 0.11660103648562337 0.012196989672603452 0.03539881084089394 1.2119876480425825e-07 6.916501806254124 -0.4404073624350492 TLSEK(ub)ETEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLSEKETEAR 10 1 P12270 P12270 TPR Nucleoprotein TPR 1 2869110.0 1184700.0 1034300.0 650110.0 True False 1147092.3469719936 1447301.383803244 479826.6881180537 1.0 1.26171305006412 0.4182982210496508 20.129550109898133 -6.82335244024453 1.3572675634744844 1.1406048289443997 0.3985217234103593 0.8919272104700806 0.11587784459856383 0.18916183476767537 0.683782337251379 0.06707353298908647 0.1544759940565661 1.501922625659104e-07 6.82335244024453 -0.7420831055340404 down TLSEK(ub)ETEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLSEKETEAR 10 1 P12270 P12270 TPR Nucleoprotein TPR 1 5548000.0 1346000.0 2291600.0 1910400.0 True False 2041980.405780929 1882646.0756474787 1532808.602641936 1.0 0.9219706860641913 0.7506480465250758 20.9615375919462 -6.958179511017071 0.4603734636082969 1.0049751683973902 0.6607328926302926 0.9996966037689703 0.0018140241699587587 0.0803579724380664 0.023583486029557146 0.0023282353268380446 0.014152399729748556 1.1010840940387469e-07 6.958179511017071 -0.34424227576709765 TLSEK(ub)ETEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLSEKETEAR 10 1 P12270 P12270 TPR Nucleoprotein TPR 1 2799420.0 816580.0 859140.0 1123700.0 True False 1118491.6932447534 821180.3540039451 858305.203327946 1.0 0.7341854740303831 0.7673773605220041 20.093123111229385 -10.103224579745707 7.533712936251351 1.0000000437051018 0.7507814173778112 0.9868712055400136 0.01355053091747485 9.936710942316433e-09 1.1937433942553677e-09 0.01312024748998756 0.0043734150479707344 7.884522924828144e-11 10.103224579745707 -0.24921862632729053 TLSEK(ub)ETEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLSEKETEAR 10 1 P12270 P12270 TPR Nucleoprotein TPR 1 4601200.0 1346000.0 2145000.0 1110200.0 True False 1742423.5336266116 2025628.864393461 908154.991613968 1.0 1.162535299427113 0.5212022072060575 20.73266391403865 -6.839519408669979 1.2845541115856234 1.0864742476102422 0.500299363761055 0.9236319884296976 0.07522958611358467 0.16936445422482652 0.5430599609336357 0.04592487603512984 0.10579295657762072 1.4470401832588916e-07 6.839519408669979 -0.5861748838491873 TLSEK(ub)NNITQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLSEKNNITQK 11 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 14685100.0 4332100.0 5149500.0 5203500.0 True False 5679425.052116077 4381214.672593788 4665091.73549654 1.0 0.7714186968558387 0.8214021124829157 22.43731345742653 -10.735290114209574 6.864492775851916 1.0031021049042672 0.7964104046693781 0.9567486317825133 0.02040564398129891 0.0009811730143998057 3.78361380351643e-05 0.020010799197839577 0.006585893275684028 1.839542753100864e-11 10.735290114209574 -0.20669170023488914 TLSEK(ub)NNITQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLSEKNNITQK 11 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 13982500.0 3954300.0 4380100.0 5648100.0 True False 3828772.9109743834 6129096.7719197525 4168693.1706320117 1.0 1.6007992415407997 1.0887804702867903 21.868450664109616 -10.243683268452367 4.259284900945211 0.9997928976183292 1.3447898556102378 0.3767959340489061 0.209030788088964 21752659.322531927 52315804.50371461 25313.93214155208 0.07155679739776868 5.70580245515058e-11 10.243683268452367 0.34499695799190855 TLSEK(ub)NNITQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLSEKNNITQK 11 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 45032200.0 6237900.0 10839300.0 27955000.0 True False 9463350.351575667 8904942.227162547 22429681.99688824 1.0 0.9409925551028401 2.370162908863841 23.173919606999153 -6.8972701641257155 0.9783777695341326 0.9360483451955187 2.5121254537259827 0.9851581360094487 0.0804362538818813 0.11344219053560599 0.1889747387828243 0.06196443292363669 0.15912004687241088 1.26686353542314e-07 6.8972701641257155 1.576077108530464 up TLSEK(ub)NNITQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLSEKNNITQK 11 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 11770260.0 4332100.0 3209060.0 4229100.0 True False 5933794.440600553 3067273.1182576763 3230273.6810485153 1.0 0.5169159715528064 0.5443858417046181 22.50052351894942 -10.693466311116024 6.710304800186728 1.0041168163855836 0.5306509066287172 0.9974374738515528 0.011214527528741415 0.000693943017809296 3.1699989678313154e-05 0.010909475019708788 0.0036194731962000052 2.0255067223704074e-11 10.693466311116024 -0.4734659097568664 TLSEK(ub)NNITQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLSEKNNITQK 11 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 14794000.0 3954300.0 6072600.0 4767100.0 True False 3288175.655192358 6039885.698483268 5763878.569419976 1.0 1.836850074887479 1.7529107851395458 21.648855939543893 -10.09534937133241 4.4355647987782545 0.9999238145637221 1.7948804300544048 0.991705864384078 0.03426807171233045 5044198.980656181 3826869.6400990756 3362.1409222210727 0.01173087191396697 8.028799797254472e-11 10.09534937133241 0.7949566154906826 TLSEK(ub)NNITQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLSEKNNITQK 11 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 22104700.0 6237900.0 7469100.0 8397700.0 True False 8075084.517391851 7053438.019133422 6869404.767678443 1.0 0.8734816340240104 0.8506913770231563 22.945045929091602 -13.99999999997359 0.24108096710776963 1.8418382989738669 0.8407175828613461 0.9995267590149545 0.0014286983660240751 13.661803633401789 0.15539703914717046 5.5403485730097275 0.011065894866316364 1.0000000000608133e-14 13.99999999997359 -1.0011207161125206 TLSFYFPPCGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLSFYFPPCGK 11 0 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 0 8406200.0 2423700.0 3175700.0 2806800.0 False True 3177494.171144186 2701897.9387816424 2516379.260726761 1.0 0.850323491800054 0.7919382775203129 21.59945804804958 -13.999999999999998 0.13018929675649907 1.7113158436756475 0.7103700300047346 0.9996447563316724 0.0016515176715320345 11.936495451906785 0.11222493838344776 2.172298145717643 0.07254659216113794 1.0000000000000041e-14 13.999999999999998 -1.0009458136709128 TLSFYFPPCGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLSFYFPPCGK 11 0 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 0 7480900.0 2423700.0 2204700.0 2852500.0 False True 3319807.38802972 2107289.0640320554 2178798.2490815767 1.0 0.634762447854758 0.6563026086807634 21.662668109572472 -10.33202015128092 5.703430116531257 1.0000549287860723 0.64553252826776 0.9972381160386486 0.00879373383354063 6.142977908781417e-06 7.194653263987443e-07 0.008515811078693654 0.0028381653906892367 4.655644908112248e-11 10.33202015128092 -0.3545224005183123 TLSGMESYCVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLSGMESYCVR 11 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 1797230.0 800290.0 996940.0 0.0 False True 1049187.9400193833 848200.4380416825 0.0 1.0 0.8084351770436975 0.0 20.000841698953334 -7.237712928910638 0.8623123816899503 0.989522521243748 2.199618092465844e-16 0.9889563344836089 0.04554206317230944 0.09701706924219274 0.1385758554057235 0.038538323217351435 0.06779752524938333 5.784782984578737e-08 7.237712928910638 -0.9895225212437477 down TLSGMESYCVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLSGMESYCVR 11 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 47554400.0 6528800.0 33521000.0 7504600.0 False True 9904666.919214355 27538915.649231575 6021312.520616967 1.0 2.7803979552111966 0.6079268055885904 23.23967702933773 -6.6888924724269225 1.8702163181317668 2.117352591245778 0.6155091938047088 0.36527971110152313 0.7531535667319293 0.4190691184576411 2.840988554756726 0.3222559683282767 0.8403920805151147 2.0469513815206356e-07 6.6888924724269225 -1.5018433974410692 TLSGMESYCVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLSGMESYCVR 11 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 23894600.0 6528800.0 8381700.0 8984100.0 False True 8451660.301888123 7915251.026893556 7349085.984650547 1.0 0.9365320829476864 0.8695434650880066 23.01080335143018 -6.9704452244912165 0.24739388650891275 1.0219523925418603 0.7821678116837772 0.9999856182073427 0.0002019165769107125 0.07615907222032663 0.008515031871213661 0.0015208715924255934 0.006447901883523902 1.070421381583585e-07 6.9704452244912165 -0.23978458085808307 TLSLCHVIHFCAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLSLCHVIHFCAK 13 0 V9GZ03;P51398-2;P51398-3;P51398;V9GYL9 V9GZ03 DAP3 28S ribosomal protein S29, mitochondrial 0 6050200.0 1413900.0 1843200.0 2793100.0 False True 1936657.0392108026 1761761.3293526918 2133427.3057001773 1.0 0.909691955613689 1.1016030523244114 20.885137060364997 -6.778777861329495 1.540969055144766 0.9487833339943659 1.1030562873929846 0.7629198888758 0.03817003907561455 0.25248325493438817 1.184184585188857 0.019512518437920772 0.046082151231381076 1.6642636922476363e-07 6.778777861329495 0.15427295339861868 TLSLQFVHHICITCPEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLSLQFVHHICITCPEIK 18 0 Q5VYK3;J3KN16;R4GMY1 Q5VYK3 ECM29;KIAA0368 Proteasome-associated protein ECM29 homolog 0 16114900.0 7885900.0 8229000.0 0.0 False True 11963486.836513983 6760470.6565295365 0.0 1.0 0.5650919960805889 0.0 23.512134597944737 -7.741530260340203 0.6358223735393801 1.0019450111120207 2.72900783962644e-19 0.987700349962591 0.04540399053179885 0.11895360684274293 0.1530336347718796 0.04301535911744076 0.07792999469442251 1.8133003261272172e-08 7.741530260340203 -1.0019450111120207 down TLSSFFTPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLSSFFTPR 9 0 P18858;M0R0Q7;F5GZ28;P18858-2;P18858-3;B4E135 P18858 LIG1 DNA ligase 1;DNA ligase 0 3720090.0 870990.0 1356200.0 1492900.0 False True 1141876.3246791582 1153860.2464261958 1338429.0289080022 1.0 1.010494938451767 1.1721313420558666 20.122974971833813 -6.9201068215862485 0.8239424544898458 0.9964472839811195 1.1982600944754516 0.9942103402962865 0.005994839613861506 0.09810900668348876 0.10529169170287773 0.005168081040435634 0.015496508123060044 1.2019687550584508e-07 6.9201068215862485 0.20181281049433208 TLSSPTEPVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLSSPTEPVKR 11 1 P40306;J3QQN1 P40306 PSMB10 Proteasome subunit beta type-10 1 13131800.0 1575700.0 3892200.0 7663900.0 True False 1525680.2659945716 5446375.757554856 5656494.677928267 1.0 3.569801536368718 3.7075230007257582 20.541021220228387 -10.29365171976826 0.6080909954070366 3.837736348024192e-16 3.690902010712722 0.999755803345407 0.01945765928079092 1.6117227583137597 0.2946509917858639 2.7438976113221267 0.023648934568192784 5.0856712186487166e-11 10.29365171976826 3.6909020107127217 TLSSPTEPVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLSSPTEPVKR 11 1 P40306;J3QQN1 P40306 PSMB10 Proteasome subunit beta type-10 1 11230900.0 1575700.0 4640800.0 5014400.0 True False 1310264.3653457244 4615799.0892733205 6062887.856033969 1.0 3.52279983441006 4.627224868802888 20.321426495662664 -9.048939438342142 0.3083500373746915 2.810325451633598e-20 5.086091739274298 0.9985478469497454 0.057849570591136754 0.4997916753477301 0.10909195571084226 0.9481549480256282 0.36622777698400616 8.934300624133869e-10 9.048939438342142 5.086091739274298 TLSYLLPAIVHINHQPFLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLSYLLPAIVHINHQPFLER 20 0 J3KTA4;P17844;J3QRQ7;J3QRN5 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 190156760.0 66131480.0 117718900.0 6306380.0 False True 86699010.6981632 100155698.98467818 5653856.292668524 1.0 1.1552115552202036 0.06521246606091097 26.36951219550182 -6.870810454583834 1.1298525975193503 1.088220439895489 0.000400512574636641 0.9654826002619525 0.08944511711482406 0.13607752694837438 0.32418016589198984 0.06140972299562626 0.14559242295999963 1.3464478755384779e-07 6.870810454583834 -1.0878199273208522 down TLSYLLPAIVHINHQPFLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLSYLLPAIVHINHQPFLER 20 0 J3KTA4;P17844;J3QRQ7;J3QRN5 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 737546850.0 421658800.0 150553350.0 165334700.0 False True 408273472.198358 210670087.78034818 122028582.13531855 1.0 0.5160023908631394 0.2988893240558903 28.604960589774368 -11.49619354723821 0.1431992916151579 2.1770426212068887 2.569841297884879e-13 0.9996646061595068 0.0053669946207759766 4.2377221861036265 0.09098353172126049 1.7800870763773164 0.21976210210744443 3.1901158344697666e-12 11.49619354723821 -2.1770426212066316 TLSYLLPAIVHINHQPFLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLSYLLPAIVHINHQPFLER 20 0 J3KTA4;P17844;J3QRQ7;J3QRN5 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 1498779600.0 432006700.0 420242100.0 646530800.0 False True 655385747.8202679 345246613.88848585 518743703.99548334 1.0 0.5267838292741847 0.7915089788277527 29.287769059119352 -10.141524225853795 5.413894060761481 1.0000076713356492 0.6591464040508684 0.6885188626692634 0.10807358974838907 1.000712213688823e-05 1.5870357645681558e-06 0.10464415689115614 0.03488060110497901 7.218978928409005e-11 10.141524225853795 -0.3408612672847807 TLSYLLPAIVHINHQPFLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLSYLLPAIVHINHQPFLER 20 0 J3KTA4;P17844;J3QRQ7;J3QRN5 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 266329940.0 66131480.0 45227760.0 154970700.0 False True 90582075.29204914 43229448.014998145 118369812.3817515 1.0 0.4772406447480964 1.3067686073664226 26.43272225702471 -6.736373016551458 1.699918592488309 0.6876576908183298 1.3068843462580004 0.5885468498658464 0.2196687394718167 0.32443303164463677 1.8393592449492413 0.10228726720072903 0.25201556376453343 1.834961613473288e-07 6.736373016551458 0.6192266554396706 TLSYLLPAIVHINHQPFLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLSYLLPAIVHINHQPFLER 20 0 J3KTA4;P17844;J3QRQ7;J3QRN5 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 674231810.0 421658800.0 114501910.0 138071100.0 False True 350627974.85209143 113885065.48398033 166941128.6413631 1.0 0.3248031350950291 0.47612039145417706 28.385365865208644 -10.168407481350327 7.967166635676442 1.0000001420302078 0.4004617632785386 0.9544030063087753 0.06177501122630425 1.5584669901013218e-07 1.622119670908747e-08 0.05981341168302938 0.019937799140937712 6.78566661557949e-11 10.168407481350327 -0.5995383787516693 TLSYLLPAIVHINHQPFLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLSYLLPAIVHINHQPFLER 20 0 J3KTA4;P17844;J3QRQ7;J3QRN5 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 780403100.0 432006700.0 203232300.0 145164100.0 False True 559241189.275165 191922243.84945053 118745723.3094481 1.0 0.34318331254928097 0.21233365064428636 29.0588953812118 -13.999999999999998 0.2268134089356661 5.086075534802465 0.14675329493238512 0.9995056115602212 0.007662863332586392 13.194019353483972 0.15081866699120633 24.235921184288337 0.06929508331121408 1.0000000000000041e-14 13.999999999999998 -4.939322239870079 TLTAAAVSGAQPILSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLTAAAVSGAQPILSK 16 0 O60664-4;O60664-3;O60664;K7EL96;K7ER39 O60664-4 PLIN3 Perilipin-3 0 8440900.0 1744800.0 3831200.0 2864900.0 False True 2287449.696667233 3259599.8939006366 2568467.6300613107 1.0 1.424993038600939 1.1228520713716743 21.125308586746346 -10.505869778721772 9.49354741207322 0.9999944207093726 1.2739225549863067 0.5228803930907869 0.1233485333504454 1.4566431203456938e-05 7.58123658407873e-07 0.11943413494264499 0.0398105679537821 3.119824909551233e-11 10.505869778721772 0.2739281342769341 TLTAAAVSGAQPILSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLTAAAVSGAQPILSK 16 0 O60664-4;O60664-3;O60664;K7EL96;K7ER39 O60664-4 PLIN3 Perilipin-3 0 7630300.0 1744800.0 2232000.0 3653500.0 False True 2389899.711447065 2133382.8597630267 2790618.546194406 1.0 0.8926662694441184 1.167671820214041 21.188518648269238 -6.800901919504168 1.4526904296446215 0.9408465891148591 1.1715327700917573 0.8346504243944239 0.04601762018146594 0.21948127291807204 0.914395340802591 0.024921910507210862 0.05791561244139809 1.581605186579691e-07 6.800901919504168 0.2306861809768982 TLTAVHDAILEDLVFPSEIVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLTAVHDAILEDLVFPSEIVGK 22 0 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 0 148749000.0 35767000.0 87097000.0 25885000.0 False True 54261153.917954266 71553859.85803306 20768818.40420147 1.0 1.318694032313177 0.38275666668654007 25.693416392517065 -6.8148148272819995 1.394124732865613 1.172727440370538 0.3645049474351447 0.8720396008459859 0.13897983424792415 0.20031116225427165 0.7663381648463816 0.0783644198299455 0.18091696085418774 1.5317404197307845e-07 6.8148148272819995 -0.8082224929353934 down TLTAVHDAILEDLVFPSEIVGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLTAVHDAILEDLVFPSEIVGK 22 0 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 0 69766000.0 35767000.0 20997000.0 13002000.0 False True 46301086.57297398 19828498.492153592 10635769.411785988 1.0 0.4282512562832061 0.22970885132518906 25.464542714609514 -13.999999999999998 0.1475137397930227 3.754608180357616 0.004903190030760433 0.9995747496528443 0.006733805428762605 11.949256743333914 0.12082639305244415 9.442343227708227 0.20215920259260556 1.0000000000000041e-14 13.999999999999998 -3.7497049903268556 TLTAVHDAILEDLVFPSEIVGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLTAVHDAILEDLVFPSEIVGKR 23 1 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 15073500.0 9618300.0 2465700.0 2989500.0 True False 9312972.331291234 3450266.8684556335 2206460.266922399 1.0 0.37047966489311557 0.23692331389289928 23.15081026162322 -13.999999999999957 0.21791044588621913 4.764369641801182 0.1640374859933491 0.9994958874621661 0.0074707362553319825 12.94359819891462 0.14789833626999105 20.94398636188242 0.07494531736810864 1.0000000000000981e-14 13.999999999999957 -4.600332155807833 TLTAVHDAILEDLVFPSEIVGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLTAVHDAILEDLVFPSEIVGKR 23 1 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 78853800.0 21845800.0 11621000.0 45387000.0 True False 33141675.74190864 9547141.75471257 36416239.55617121 1.0 0.28807058004734276 1.098805016371631 24.98214321557658 -6.67480617123137 1.9205773050673203 0.5474575884973324 1.0955867193275783 0.30037226253633864 0.30208357597406665 0.4501934797042823 3.205942557842953 0.1264287465562764 0.3356535974614079 2.1144325158069162e-07 6.67480617123137 0.548129130830246 TLTAVHDAILEDLVFPSEIVGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLTAVHDAILEDLVFPSEIVGKR 23 1 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 17586200.0 9618300.0 5669800.0 2298100.0 True False 7998042.612936973 5639255.662032809 2778622.0847861497 1.0 0.7050794719336972 0.34741276325430925 22.931215537057497 -7.033948561324181 0.3002565656964194 1.0644180738229132 1.3698502482295732e-10 0.9999655753897075 0.0015655345097071523 0.07259530415902886 0.011220192212255318 0.00613674649243638 0.030723541662878905 9.24807703459212e-08 7.033948561324181 -1.0644180736859281 down TLTAVHDAILEDLVFPSEIVGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLTAVHDAILEDLVFPSEIVGKR 23 1 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 95908200.0 21845800.0 14544400.0 59518000.0 True False 28279818.74509676 13734991.35444488 48686334.70625122 1.0 0.48568173220085764 1.7215928837836911 24.75326953766903 -6.793693930426005 1.4816421950057745 0.7139179373108526 1.7360876149310789 0.8130275893671288 0.2191930492808065 0.22989726780389175 0.9969103158489827 0.11642415522874013 0.27185065240040024 1.608074146008116e-07 6.793693930426005 1.0221696776202263 TLTFALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLTFALR 7 0 Q96C86;A0A3B3ITF0 Q96C86 DCPS m7GpppX diphosphatase 0 19562400.0 6712500.0 7535200.0 5314700.0 False True 10183353.24948328 6190484.68721369 4264247.215484241 1.0 0.6079023810283519 0.41874686176683656 23.27970936509602 -13.965389963535202 0.0973566494239664 2.9432806784962473 4.4330676978248136e-21 0.9998119815351031 0.003319237596854598 11.884423545160397 0.09142300891769138 4.684302297332167 0.3708917077552615 1.0829540666261631e-14 13.965389963535202 -2.9432806784962473 TLTFALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLTFALR 7 0 Q96C86;A0A3B3ITF0 Q96C86 DCPS m7GpppX diphosphatase 0 9134600.0 4324800.0 2616900.0 2192900.0 False True 3596262.821125341 2602802.2402860206 2651425.251175991 1.0 0.7237519529986834 0.737272380539281 21.7780670286856 -10.017789088142825 7.11851562911291 1.0000000274571523 0.7305121667721729 0.9981157212098846 0.005519691429789988 2.4007983603988135e-09 3.3562356105217303e-10 0.0053444187237720354 0.0017814727486482917 9.598666703904433e-11 10.017789088142825 -0.26948786068497943 TLTFALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLTFALR 7 0 Q96C86;A0A3B3ITF0 Q96C86 DCPS m7GpppX diphosphatase 0 26542900.0 6712500.0 11116000.0 8714400.0 False True 8689463.57315649 10497384.82825067 7128468.617294857 1.0 1.2080590176681578 0.8203577306332392 23.05083568718847 -6.760942940804234 1.6090043357187174 1.1207107527947366 0.8188788892419356 0.69477883360587 0.08752204318597653 0.28133345483913275 1.435716809018664 0.04291461085516103 0.10303132481798778 1.7340318062227985e-07 6.760942940804234 -0.301831863552801 TLTGK(ub)EIEIDIEPTDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLTGKEIEIDIEPTDK 16 1 Q15843;S4R3E9;F8VSA6;E9PS38;E9PL57 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 43601000.0 8893000.0 18030000.0 16678000.0 True False 11658809.11993452 15339994.28038956 14952320.546672672 1.0 1.3157428106581537 1.282491238415322 23.474917097303326 -10.081273771726526 4.37293543010824 0.9999724814105961 1.2991170245604367 0.9908167418790471 0.013574897638059668 2024089.439759638 2337174.7716838657 443.4621856413295 0.004647048148696693 8.293278087993829e-11 10.081273771726526 0.2991445431498405 TLTGK(ub)EIEIDIEPTDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLTGKEIEIDIEPTDK 16 1 Q15843;S4R3E9;F8VSA6;E9PS38;E9PL57 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 97926000.0 31000000.0 28120000.0 38806000.0 True False 30015921.968542118 39348462.643862784 28641544.444954216 1.0 1.3109196740683675 0.9542117172003477 24.839224646652955 -6.6763525109303234 1.915209362883865 1.1973658644412724 0.9556165594918743 0.3073898744863621 0.1318819134203319 0.4466548801116888 3.1644132138267533 0.05532394884304285 0.14657917032027487 2.106917299544267e-07 6.6763525109303234 -0.24174930494939806 TLTGK(ub)EIEIDIEPTDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLTGKEIEIDIEPTDK 16 1 Q15843;S4R3E9;F8VSA6;E9PS38;E9PL57 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 112005000.0 35382000.0 46203000.0 30420000.0 True False 53677080.77068419 37957713.6643133 24407473.666440323 1.0 0.7071493665326889 0.4547094088576161 25.677802876878957 -7.0967906044871185 0.18705212481118938 1.186122767143337 1.2644567486010653e-09 0.999995275215679 0.0004842946597818652 0.07620737890091292 0.006657946810184653 0.010782216329033374 0.029509958449700013 8.002199888656247e-08 7.0967906044871185 -1.1861227658788802 down TLTGK(ub)EIEIDIEPTDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLTGKEIEIDIEPTDK 16 1 Q15843;S4R3E9;F8VSA6;E9PS38;E9PL57 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 46370000.0 8893000.0 20043000.0 17434000.0 True False 12180982.424288629 19157433.98666236 13316448.264500698 1.0 1.572733078447173 1.0932162776910321 23.538127158826217 -10.202589368001702 3.8912092399416407 0.9997511414353559 1.3329746777427285 0.39132574588079017 0.19576191468662804 21592558.56553053 11323036.642430434 45366.23887444917 0.06701451033665871 6.272066177388568e-11 10.202589368001702 0.33322353630737256 TLTGK(ub)EIEIDIEPTDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLTGKEIEIDIEPTDK 16 1 Q15843;S4R3E9;F8VSA6;E9PS38;E9PL57 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 86157000.0 31000000.0 33664000.0 21493000.0 True False 25777873.532853674 33482645.350219212 25987086.927596156 1.0 1.298890899885356 1.0081160067169948 24.61962992208723 -10.65999228236259 4.47432711872496 0.9953781867457779 1.1535034533011856 0.270917882397276 0.11870835304587687 0.005625194801371111 0.00042746289435291 0.11813576922187953 0.03831295620018795 2.187800501949806e-11 10.65999228236259 0.1581252665554077 TLTGK(ub)EIEIDIEPTDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLTGKEIEIDIEPTDK 16 1 Q15843;S4R3E9;F8VSA6;E9PS38;E9PL57 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 82801000.0 35382000.0 28498000.0 18921000.0 True False 45802696.48348948 26912061.248244688 15477572.145854676 1.0 0.5875649975748849 0.337918361453542 25.448929198971406 -8.775604797347322 0.17655238649952731 1.4042971257094699 7.766550100001124e-08 0.9997668972150516 0.004168132537325237 0.3070786091616515 0.05156757168513467 0.21326833182019037 0.14565636377911673 1.6764677472052193e-09 8.775604797347322 -1.404297048043969 down TLTGK(ub)EIEIDIEPTDKVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLTGKEIEIDIEPTDKVER 19 2 Q15843;S4R3E9;F8VSA6;E9PS38;E9PL57 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 153970000.0 45949000.0 62400000.0 45621000.0 True False 60239583.970748946 53090163.23329496 40900576.547532946 1.0 0.8813168971929555 0.6789651231222544 25.844208470652156 -6.963041641575522 0.3902068110758763 1.012399108265289 0.5406098080782625 0.9998669087081757 0.0015290087305635234 0.07863196620034255 0.017243443699924983 0.0026122874441398213 0.01701997500824945 1.0888256881595791e-07 6.963041641575522 -0.4717893001870265 TLTGK(ub)EIEIDIEPTDKVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLTGKEIEIDIEPTDKVER 19 2 Q15843;S4R3E9;F8VSA6;E9PS38;E9PL57 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 314525000.0 79188000.0 77527000.0 157810000.0 True False 76674220.28531967 108483935.39796405 116474826.80147968 1.0 1.414868452450827 1.5190872025571858 26.19223825473908 -12.055880272533377 0.2271573266552583 3.4670200139559865e-09 1.5763365438656987 0.9993747391996524 0.005606402680668448 5.348066246711782 0.1371828703233685 2.5596194459394797 0.05489325662490606 8.792648815203265e-13 12.055880272533377 1.5763365403986787 TLTGK(ub)EIEIDIEPTDKVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLTGKEIEIDIEPTDKVER 19 2 Q15843;S4R3E9;F8VSA6;E9PS38;E9PL57 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 929605000.0 206299000.0 327826000.0 395480000.0 True False 312970665.4771175 269322888.9837713 317313204.65495855 1.0 0.8605371643160039 1.0138752274792941 28.221452199790416 -13.918180299491342 14.59568335249761 9.108362682557969 0.9434855793800864 0.0 0.07077905024129227 0.0 0.0 0.0 0.02065259554472207 1.2073125093205727e-14 13.918180299491342 -8.164877103177883 TLTGK(ub)EIEIDIEPTDKVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLTGKEIEIDIEPTDKVER 19 2 Q15843;S4R3E9;F8VSA6;E9PS38;E9PL57 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 185523000.0 45949000.0 73309000.0 66265000.0 True False 62937587.02503512 70069965.97955553 50614571.770513766 1.0 1.1133246330477098 0.8042026102840654 25.907418532175047 -6.80745671566645 1.424982399989948 1.0619486224538066 0.7990922102915552 0.8531503276761198 0.04893086060307409 0.21027957814893591 0.8419873828195539 0.027002617755561047 0.06254384661067648 1.5579132978647573e-07 6.80745671566645 -0.2628564121622514 TLTGK(ub)EIEIDIEPTDKVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLTGKEIEIDIEPTDKVER 19 2 Q15843;S4R3E9;F8VSA6;E9PS38;E9PL57 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 249308000.0 79188000.0 114704000.0 55416000.0 True False 65848330.62321334 114086066.78503856 67003229.38536583 1.0 1.732558224411844 1.017538770553818 25.972643530173357 -10.551943084259555 5.79077961034073 0.9990461316407933 1.3750484974828185 0.26838601358298964 0.2919054696859444 0.003603314965429384 0.00027880337136781816 0.28330909055431563 0.094212085230043 2.805801323480185e-11 10.551943084259555 0.3760023658420253 TLTGK(ub)EIEIDIEPTDKVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLTGKEIEIDIEPTDKVER 19 2 Q15843;S4R3E9;F8VSA6;E9PS38;E9PL57 Q15843 NEDD8;NEDD8-MDP1 NEDD8 1 921739000.0 206299000.0 288720000.0 426720000.0 True False 267058122.2612456 272652478.19472224 349061338.51694447 1.0 1.0209480838332414 1.3070613077084412 27.992578521882866 -6.921609944078187 0.8126825378065534 0.9940460652856934 1.3549549134064638 0.9946169028724116 0.01027716246002261 0.09723366594448746 0.1007686338956203 0.008931188159280078 0.02717975836639346 1.1978158510190697e-07 6.921609944078187 0.3609088481207704 TLTGK(ub)TITLEVEPSDTIENVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLTGKTITLEVEPSDTIENVK 21 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 18248994690.0 3512419490.0 5534350300.0 9202224900.0 True False 4604815965.708738 4708646807.968494 8250066941.322277 1.0 1.022548315292721 1.7916170814988237 32.10049635326382 -6.913166576253081 0.8738976450796848 0.978505577056218 1.898042535231471 0.9920624746974734 0.03278368219812501 0.10236140441764008 0.12768646305226122 0.027267859832611433 0.07702970932036106 1.2213311214390122e-07 6.913166576253081 0.9195369581752529 TLTGK(ub)TITLEVEPSDTIENVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLTGKTITLEVEPSDTIENVK 21 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 27913075340.0 6919645640.0 6787369400.0 14206060300.0 True False 6699985276.780718 9497601397.08381 10485066934.7562 1.0 1.4175555623977911 1.5649388023422912 32.64151077923745 -11.87520549645879 0.17697385364043977 3.0206537629215925e-12 1.7010772367102294 0.9994767655037989 0.005473024511795896 5.013002799324904 0.11340268588504 1.9736210883136545 0.11143446479561155 1.3328905949758156e-12 11.87520549645879 1.7010772367072087 TLTGK(ub)TITLEVEPSDTIENVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLTGKTITLEVEPSDTIENVK 21 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 102598772200.0 18310850000.0 48036239400.0 36251682800.0 True False 27778898152.44717 39463797170.21868 29086521804.903046 1.0 1.4206393987855899 1.04707255288816 34.69327032495585 -10.463536365731537 6.590711826246654 0.9999318805323859 1.2338559758368748 0.3431921595164785 0.15250802621160311 0.00015269478896204659 1.24290364757493e-05 0.14770811784857596 0.04922175380670858 3.439249115566039e-11 10.463536365731537 0.23392409530448888 TLTGK(ub)TITLEVEPSDTIENVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLTGKTITLEVEPSDTIENVK 21 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 23366227950.0 3512419490.0 5979093800.0 13874714660.0 True False 4811055895.020667 5714917665.696851 10597792816.026072 1.0 1.1878718082680477 2.202799769380053 32.16370641478671 -6.938095755598727 0.6770550715190989 0.9881452823212362 2.4618064674597826 0.997903592552214 0.024189962945867914 0.08864633338011808 0.05864862529802471 0.02322023247188582 0.08811090840326288 1.1531989662366039e-07 6.938095755598727 1.4736611851385464 up TLTGK(ub)TITLEVEPSDTIENVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLTGKTITLEVEPSDTIENVK 21 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 20306413140.0 6919645640.0 438649500.0 12948118000.0 True False 5753991941.9381275 436286408.0783917 15655509608.46659 1.0 0.07582325670262174 2.720808399879913 32.421916054671726 -6.812304328280208 1.4047875030103159 0.497688164276862 2.769582511576265 0.8657760148983749 0.4015423674907164 0.20366856650119192 0.7917056881481506 0.2247271952431855 0.5193279681022898 1.5406204974877732e-07 6.812304328280208 2.271894347299403 TLTGK(ub)TITLEVEPSDTIENVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLTGKTITLEVEPSDTIENVK 21 1 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 81922939800.0 18310850000.0 38192133800.0 25419956000.0 True False 23703756285.81488 36066707980.446144 20793784838.774475 1.0 1.5215608676347077 0.8772358519066521 34.46439664704829 -6.691314661955726 1.8614559363056786 1.3265715599653887 0.8794073665766914 0.3767546597683783 0.22052336114729107 0.41382790027756855 2.7810620991262023 0.09473107657924532 0.24630452275143289 2.0355667020782437e-07 6.691314661955726 -0.4471641933886973 TLTGK(ub)TITLEVEPSDTIENVK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLTGKTITLEVEPSDTIENVKAK 23 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 131563800.0 18474000.0 36404000.0 76685800.0 True False 24219592.902470488 30972665.101680607 68751089.03813605 1.0 1.2788268253064352 2.8386558483864186 24.529671279758933 -6.937334228862934 0.6839110404725648 0.9814233436889963 3.22823793446893 0.9977935179061629 0.03800499180216125 0.08900404467255542 0.060306631364742846 0.036286591389618456 0.1359030601747668 1.1552228515892756e-07 6.937334228862934 2.2468145907799335 up TLTGK(ub)TITLEVEPSDTIENVK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLTGKTITLEVEPSDTIENVKAK 23 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 431928000.0 39314000.0 117625000.0 274989000.0 True False 38065998.58939558 164593275.90627158 202961131.4068319 1.0 4.323892239940448 5.3318220702969485 25.18199958928278 -9.338015202958294 0.3868716818096406 1.4876726276431923e-22 5.505789821815281 0.9981198184853196 0.08025228350305098 0.7102416633854851 0.15343903972768871 1.3030521760258071 0.26297969896845497 4.5918193838430597e-10 9.338015202958294 5.505789821815281 TLTGK(ub)TITLEVEPSDTIENVK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLTGKTITLEVEPSDTIENVKAK 23 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 1110967000.0 113800000.0 559400000.0 437767000.0 True False 172642919.8944055 459570699.3878512 351242160.56990737 1.0 2.6619724670374016 2.0345008111814806 27.36321592941719 -10.299441022821373 5.464908919858117 0.9997998940231924 2.348236639109436 0.8602527395449343 0.25616423081785855 0.0006246541305437024 8.00765610430444e-05 0.24806516844209253 0.08267664998761157 5.0183272327954815e-11 10.299441022821373 1.3484367450862438 TLTGK(ub)TITLEVEPSDTIENVK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLTGKTITLEVEPSDTIENVKAK 23 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 188400700.0 18474000.0 46951700.0 122975000.0 True False 25304337.04107814 44877218.645490944 93930837.74962558 1.0 1.7734990872370575 3.712044998339284 24.592881341281824 -6.955408962462212 0.4959279105951177 0.9597684215933691 4.608809159942105 0.9995602007078799 0.023922761710200132 0.08138385923659679 0.02751648920373718 0.028274833706934822 0.15989480284608 1.108130829272889e-07 6.955408962462212 3.6490407383487358 TLTGK(ub)TITLEVEPSDTIENVK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLTGKTITLEVEPSDTIENVKAK 23 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 267613000.0 39314000.0 114220000.0 114079000.0 True False 32691332.905503478 113604674.18910505 137932391.45829973 1.0 3.4750701208019596 4.219234249548732 24.962404864717055 -9.521342099552763 0.35432375007471706 1.0596597237110561e-19 4.390970114390933 0.9984434339713031 0.05429231510752663 0.8763084889185561 0.1449059166681401 1.2839185128053439 0.21485143810966253 3.0106335737040655e-10 9.521342099552763 4.390970114390933 TLTGK(ub)TITLEVEPSDTIENVK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLTGKTITLEVEPSDTIENVKAK 23 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 2 1046006000.0 113800000.0 626060000.0 306146000.0 True False 147316343.33336443 591219210.6490301 250430569.3232297 1.0 4.01326286867677 1.69995102822045 27.13434225150964 -6.579249163952721 2.269297564383913 3.0528596177595713 1.7055309729264703 0.0 1.3092947161470847 0.7017142118847369 6.795495089019585 0.4846198585954383 1.464266230722838 2.634819300409757e-07 6.579249163952721 -1.347328644833101 TLTGK(ub)TITLEVEPSDTIENVKAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLTGKTITLEVEPSDTIENVKAK 23 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 85136000.0 25371700.0 17529500.0 42234800.0 True False 33262544.39989231 14914166.929455826 37864748.040808976 1.0 0.44837721222264976 1.1383599398045918 24.987395195215115 -6.693791839144837 1.8526166549903462 0.6553957917253257 1.136106399612004 0.3882260943770389 0.23312317349833223 0.40865284660697204 2.7221117729664424 0.10054908378075086 0.26062362768516617 2.0239890605382785e-07 6.693791839144837 0.4807106078866783 TLTGK(ub)TITLEVEPSDTIENVKAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLTGKTITLEVEPSDTIENVKAK 23 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 86038000.0 26169000.0 25711000.0 34158000.0 True False 25338279.41918638 35977536.38109377 25210995.08196527 1.0 1.4198886903840537 0.9949765990375523 24.594815226666423 -11.853813378216731 15.422314077090189 1.10582380704717 1.1866906168668538 0.0 0.20493006331470862 0.0 0.0 0.0 0.0588771835312735 1.4001888720280237e-12 11.853813378216731 0.08086680981968386 TLTGK(ub)TITLEVEPSDTIENVKAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLTGKTITLEVEPSDTIENVKAK 23 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 403444000.0 86731000.0 167870000.0 148843000.0 True False 131577267.88542786 137912286.92570347 119424115.80979557 1.0 1.048146759254736 0.9076348652700802 26.971335020650944 -6.814214053033565 1.3967580853846424 1.0261117753619367 0.9049326325758763 0.8705486206663513 0.020976993988737126 0.2011060264362454 0.7724368634916369 0.011806365346966743 0.02726204737779139 1.5338607943250073e-07 6.814214053033565 -0.12117914278606035 TLTGK(ub)TITLEVEPSDTIENVKAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLTGKTITLEVEPSDTIENVKAK 23 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 93718300.0 25371700.0 34774600.0 33572000.0 True False 34752303.13441173 33238143.187775675 25642985.037043553 1.0 0.9564299395991187 0.7378787223932756 25.050605256738006 -6.939733689381517 0.6620372290996417 1.0024647360521615 0.6794014471550699 0.9981287939648071 0.004960907018480764 0.08788837458100558 0.0551646945441369 0.004819375772050374 0.01883245162372317 1.148857888488762e-07 6.939733689381517 -0.32306328889709157 TLTGK(ub)TITLEVEPSDTIENVKAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLTGKTITLEVEPSDTIENVKAK 23 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 83805300.0 26169000.0 23775000.0 33861300.0 True False 21760682.983266033 23646919.356031973 40941541.27303827 1.0 1.0866809361735776 1.8814456009732008 24.3752205021007 -6.927650195673543 0.7658262671129493 0.9868032155063218 2.035258785498751 0.9960562015696346 0.02491062974699958 0.09387581815909563 0.08379025110984603 0.022385531287787384 0.07286334195062655 1.1812717128707624e-07 6.927650195673543 1.0484555699924294 TLTGK(ub)TITLEVEPSDTIENVKAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLTGKTITLEVEPSDTIENVKAK 23 2 P62979;P0CG48;F5H2Z3;Q96C32;Q5PY61;J3QKN0;F5GXK7;F5H747;F5H388;B4DV12;F5H265;F5GYU3;F5H6Q2;J3QTR3;J3QS39;P62987;P0CG47;Q49A90;M0R1V7;F5GZ39;J3QSA3 P62979 RPS27A;UBC;UBB;UBA52 Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a;Polyubiquitin-C;Ubiquitin;Ubiquitin-60S ribosomal protein L40;Ubiquitin;60S ribosomal protein L40;Polyubiquitin-B;Ubiquitin 1 402695000.0 86731000.0 171108000.0 144856000.0 True False 112274989.2236031 161585689.38397956 118493694.34807506 1.0 1.4391957683662826 1.0553881605108597 26.742461342743393 -10.37637739348084 6.278259560180771 0.9999699430151877 1.2472919644385712 0.356299616422289 0.15668879977400121 6.592917245683902e-05 6.548646951561413e-06 0.15173168975343537 0.05057109267182793 4.203611839102144e-11 10.37637739348084 0.24732202142338344 TLTLALIWQLMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 TLTLALIWQLMR 12 0 P13796;P13796-2 P13796 LCP1 Plastin-2 0 3392027500.0 939970400.0 1239481100.0 1212576000.0 False True 1426003817.8410559 1018286013.5949628 972909822.1090581 1.0 0.7140836517090323 0.682263125762192 30.409330698301712 -13.999999999999998 0.3099834445913646 3.763493248073575 0.6752149650427203 0.9996719586199357 0.0025877192413710694 17.26843925113489 0.1771486947098713 30.780035980138482 0.011027606979909153 1.0000000000000041e-14 13.999999999999998 -3.0882782830308546 TLTLALIWQLMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLTLALIWQLMR 12 0 P13796;P13796-2 P13796 LCP1 Plastin-2 0 152577000.0 67416000.0 25499000.0 59662000.0 False True 87271340.96803239 24079958.234577548 48804128.18381604 1.0 0.27592057103142337 0.5592228518832209 26.379004629275887 -10.405492190446804 5.966110130280256 1.0001653268516202 0.4175717114583919 0.849292821606106 0.11565767184226058 0.00025440867098864607 2.5350952064431496e-05 0.11201626382033637 0.03732835307551632 3.9310431370888045e-11 10.405492190446804 -0.5825936153932283 TLTLRK(ub)SK(ub)TACGPLSAEALAK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLTLRKSKTACGPLSAEALAK 21 3 H0YN02;H0YLX4;H0YKE0;Q3MJ13 H0YN02 WDR72 WD repeat-containing protein 72 3 59465900.0 9177900.0 35717000.0 14571000.0 True False 13923545.294366114 29343022.29180531 11691035.463303816 1.0 2.1074389942681035 0.8396593838807965 23.731023269605636 -6.675883967399518 1.9164520130492666 1.703274814480764 0.8446316128328344 0.3053341746908327 0.4697900537290401 0.4477847572749902 3.1759933260971023 0.19695698592194227 0.5222275383399508 2.1091915977908794e-07 6.675883967399518 -0.8586432016479295 TLTLRK(ub)SK(ub)TACGPLSAEALAK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLTLRKSKTACGPLSAEALAK 21 3 H0YN02;H0YLX4;H0YKE0;Q3MJ13 H0YN02 WDR72 WD repeat-containing protein 72 3 50330900.0 9177900.0 25349000.0 15804000.0 True False 11880972.473455928 23938305.866438154 12927834.16273388 1.0 2.014843980147275 1.0881124581019623 23.502149591698085 -6.624475964576732 2.099866961205435 1.6712269890747191 1.0916978433795177 0.09823399738692962 0.4359156787615689 0.5734796432795377 4.811015262874782 0.1701909306631213 0.48328401433012985 2.3742368179291242e-07 6.624475964576732 -0.5795291456952014 TLTLVDTGIGMTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLTLVDTGIGMTK 13 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 600954400.0 162071400.0 207561000.0 231322000.0 False True 212477174.90167004 176593707.8664411 207387018.43730798 1.0 0.8311184857769544 0.9760437493264033 27.662732628938326 -10.164156828213196 5.886606823083055 1.0000011584624744 0.9035811175613854 0.3711351255188474 0.059165491089094475 8.995453152684507e-07 1.2776018624705215e-07 0.057287428441067795 0.019095580138186137 6.852407342782166e-11 10.164156828213196 -0.09642004090108902 TLTLVDTGIGMTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLTLVDTGIGMTK 13 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 569196500.0 212136000.0 116263500.0 240797000.0 False True 205401858.79737565 162688121.85614288 177725041.94484428 1.0 0.7920479532594253 0.8652552756115321 27.61387399657595 -10.64188704568225 9.146053055417386 1.0000908991734245 0.8286516156005178 0.8795831672602892 0.029886764199684567 5.542472836409848e-05 2.170143363203544e-06 0.028952980830880454 0.0096459116681172 2.2809352362990606e-11 10.64188704568225 -0.17143928357290672 TLTLVDTGIGMTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLTLVDTGIGMTK 13 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 1052171000.0 159770000.0 693990000.0 198411000.0 False True 242382770.75157437 570142062.3313807 159194978.88336957 1.0 2.352238406069452 0.6567916456674779 27.852711910737 -6.694249795665941 1.8512824884305847 1.8443574044500983 0.6623216142441718 0.3904338310402482 0.5714159406952525 0.40757900392730756 2.7114630520252003 0.24662413196550767 0.6388150696458056 2.021855921621625e-07 6.694249795665941 -1.1820357902059264 TLTLVDTGIGMTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLTLVDTGIGMTK 13 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 560998400.0 162071400.0 174333000.0 224594000.0 False True 221993576.3949003 166630391.61786178 171549522.85862508 1.0 0.750609068622085 0.7727679586253379 27.725942690461217 -10.760213040328122 6.918138021504943 1.005227158758783 0.761688513623731 0.9935574105113644 0.009046328962404775 0.0007402166815778643 2.5656342248182356e-05 0.008889712794866956 0.002919690117975629 1.736948570928646e-11 10.760213040328122 -0.24353864513505208 TLTLVDTGIGMTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLTLVDTGIGMTK 13 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 401130400.0 212136000.0 115736400.0 73258000.0 False True 176400483.21824008 115112905.04132316 88575909.09327874 1.0 0.6525657013020036 0.5021296284301779 27.394279272010227 -13.999999999999858 0.11402060181048064 2.6661077028895495 0.2414730985965774 0.9997227117734496 0.0034717820042559125 11.990508225701642 0.10310006268878497 4.566892289826345 0.2313427505589687 1.0000000000003272e-14 13.999999999999858 -2.4246346042929723 TLTLVDTGIGMTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLTLVDTGIGMTK 13 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 573480000.0 159770000.0 235380000.0 178330000.0 False True 206825414.53753626 222280896.08435062 145875769.82031953 1.0 1.0747271875720543 0.7053087269110484 27.62383823282945 -6.854050015159296 1.2153392257900517 1.0400621467284545 0.6893416791760054 0.9459995804511935 0.03705932038370683 0.15305820985949942 0.43300529087088463 0.02383309716164223 0.05531512420443682 1.399426149554817e-07 6.854050015159296 -0.3507204675524491 TLTPDQWAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLTPDQWAR 9 0 A0A087WZT3;Q9H3K6 A0A087WZT3 BOLA2 BolA-like protein 2 0 19374100.0 4521600.0 8599500.0 6253000.0 False True 5927861.387236685 7316488.120588462 5605999.543011405 1.0 1.2342542516836912 0.9457035475022606 22.499080282439536 -6.690788095349466 1.8635742759062328 1.1467576533045891 0.9466916021216072 0.374047166364043 0.09905797833612852 0.41502648104672957 2.7951241879735678 0.04251289007409173 0.11059836666655938 2.0380362510926882e-07 6.690788095349466 -0.20006605118298193 TLTPDQWAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLTPDQWAR 9 0 A0A087WZT3;Q9H3K6 A0A087WZT3 BOLA2 BolA-like protein 2 0 15612200.0 5145500.0 2983000.0 7483700.0 False True 4982158.919004306 4174127.4561394937 5523494.463812387 1.0 0.8378149962694689 1.1086548128248521 22.24833961017285 -6.744496787529164 1.6699601331618268 0.9040093820755124 1.1089837630166905 0.6250944922346602 0.06814077428514559 0.3097274335164621 1.697560421028802 0.032256561356963774 0.07877573138584618 1.8009564560449688e-07 6.744496787529164 0.20497438094117815 TLTPDQWAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLTPDQWAR 9 0 A0A087WZT3;Q9H3K6 A0A087WZT3 BOLA2 BolA-like protein 2 0 80006000.0 11322000.0 55201000.0 13483000.0 False True 17176301.74907258 45349950.2626185 10818079.140191155 1.0 2.6402627832890233 0.6298258669550485 24.033916105657486 -6.689819487277873 1.8674735883920148 2.0285285454351456 0.6368652361076438 0.36944492964603826 0.6937420177255154 0.4170281723011154 2.819731934361316 0.2972294888973441 0.7740635950092011 2.0425867610726737e-07 6.689819487277873 -1.3916633093275017 TLTPDQWAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLTPDQWAR 9 0 A0A087WZT3;Q9H3K6 A0A087WZT3 BOLA2 BolA-like protein 2 0 21321800.0 4521600.0 6627200.0 10173000.0 False True 6193357.711645494 6334388.390780261 7770346.919511607 1.0 1.0227712794417774 1.2546258881351013 22.562290343962427 -6.925901654089272 0.7796831539895277 0.9958877958678899 1.2976125936173022 0.9956700006717552 0.007569995369027906 0.09482197989710664 0.08851480503083081 0.006735391948307367 0.021470875873577183 1.1860372957013529e-07 6.925901654089272 0.3017247977494123 TLTPDQWAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLTPDQWAR 9 0 A0A087WZT3;Q9H3K6 A0A087WZT3 BOLA2 BolA-like protein 2 0 10496300.0 5145500.0 2898300.0 2452500.0 False True 4278711.234299955 2882686.2826324934 2965306.410921207 1.0 0.6737277008842437 0.6930372835516591 22.028744885607125 -10.142209682576658 5.189743951410044 1.0000111898126351 0.6833824922176714 0.9972181890593214 0.007883104114529126 1.0206590557411427e-06 1.6869773934791479e-07 0.007633052389349025 0.0025442609125239744 7.207594038907128e-11 10.142209682576658 -0.3166286975949637 TLTPDQWAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLTPDQWAR 9 0 A0A087WZT3;Q9H3K6 A0A087WZT3 BOLA2 BolA-like protein 2 0 40365000.0 11322000.0 15924000.0 13119000.0 False True 14656552.189985521 15037815.401678994 10731476.612307364 1.0 1.026013158262008 0.7321965270686193 23.805042427749935 -6.885310235690606 1.049691046566331 1.017607104999178 0.709127518063899 0.9777242748146758 0.01982053632018602 0.12303230960292556 0.24471760054355776 0.014468201551924973 0.035512434001735704 1.3022362013990892e-07 6.885310235690606 -0.308479586935279 TLVDIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLVDIAK 7 0 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 0 9884200.0 1372800.0 5372200.0 3139200.0 False True 1799754.0942141088 4570688.700671584 2814385.697332709 1.0 2.5396184486344775 1.563761241816569 20.77936836960514 -9.957922131674636 5.743440724510045 0.9999989116334626 2.051689845226213 0.6076289771140271 0.3983920364226928 5.551216903912405e-06 1.008801437882484e-06 0.38574183285820246 0.12858047686020652 1.1017368315341069e-10 9.957922131674636 1.0516909335927505 TLVDIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLVDIAK 7 0 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 0 6190300.0 2689700.0 1385000.0 2115600.0 False True 2604316.945767344 1938037.7226795878 1561460.893360437 1.0 0.7441635419334717 0.5995663837683793 21.31247360471773 -13.99999999963884 0.06621109736769444 2.530036078402582 0.03122950192876515 0.9999366844284997 0.001317410752838893 12.399618477662356 0.06814989222008878 3.003436158447315 0.5267726356142093 1.0000000008316015e-14 13.99999999963884 -2.498806576473817 TLVDIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLVDIAK 7 0 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 0 42129800.0 6325800.0 31611000.0 4193000.0 False True 9596701.077926448 25969770.072129685 3364251.712142813 1.0 2.706114305452656 0.3505633534716416 23.194107125528042 -6.712391990150859 1.7865317837366115 2.0462740731029925 0.3556414264993319 0.47659206387342223 0.7186791921011163 0.3702489292048413 2.3049783408617985 0.31994294245686533 0.810501117693875 1.9391348424455377e-07 6.712391990150859 -1.6906326466036605 TLVDIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLVDIAK 7 0 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 0 9529800.0 1372800.0 4378800.0 3778200.0 False True 1880361.2585250635 4185330.137244782 2885866.9744715174 1.0 2.225811725416909 1.5347407108010525 20.842578431128032 -10.289858031883284 5.342645727783672 0.9998585568183563 1.8802762181090404 0.6838816869244632 0.2821285603062605 0.00047539600252038353 6.318901065228294e-05 0.27321285408868984 0.09105660129627151 5.130290625360185e-11 10.289858031883284 0.8804176612906841 TLVDIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLVDIAK 7 0 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 0 5250600.0 2689700.0 1456800.0 1104100.0 False True 2236604.7239134344 1448951.929247842 1334962.2052183913 1.0 0.6478354953630698 0.5968699748083245 21.092878880152007 -13.999999999999998 0.2722414165294708 3.7511438191926696 0.5803167819957623 0.9995881665375596 0.0036373613533873805 14.994095995494508 0.16519094998502232 22.861302484358934 0.020932593455488598 1.0000000000000041e-14 13.999999999999998 -3.1708270371969074 TLVDIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLVDIAK 7 0 Q99832;Q99832-3;F8WAM2 Q99832 CCT7 T-complex protein 1 subunit eta 0 17352300.0 6325800.0 5934000.0 5092500.0 False True 8188872.800159894 5603767.683594778 4165717.253462555 1.0 0.6843149014947895 0.5087045989261447 22.96523344762049 -11.83072740091933 0.08832407872816508 2.1836472396039293 1.922851758313765e-09 0.9999076484923067 0.001953407264337666 5.2306804587668925 0.06352764874883121 1.5497340976787999 0.36794333299147797 1.4766330993235726e-12 11.83072740091933 -2.1836472376810776 TLVGVGASLGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLVGVGASLGLR 12 0 C9JGI3;P19971;P19971-2;A0A494C1N7;A0A494C0L6 C9JGI3 TYMP Thymidine phosphorylase 0 28116900.0 7072500.0 11750000.0 9294400.0 False True 10729499.56900864 9653120.696830966 7457357.7661197595 1.0 0.8996804216958344 0.6950331390720013 23.3550794536195 -6.9596560821854005 0.4402537420037241 1.0072979867546863 0.5794333082493721 0.9997572292322281 0.001977348291788034 0.07982419638031303 0.021586964016253103 0.0026990047821212953 0.016955493776498503 1.0973468411576307e-07 6.9596560821854005 -0.4278646785053142 TLVGVGASLGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLVGVGASLGLR 12 0 C9JGI3;P19971;P19971-2;A0A494C1N7;A0A494C0L6 C9JGI3 TYMP Thymidine phosphorylase 0 26769500.0 7072500.0 12582000.0 7115000.0 False True 9155490.669817397 11881800.6395331 5820143.006065011 1.0 1.2977786847299664 0.6356997364709336 23.12620577571195 -6.784420641728305 1.5184625203487776 1.1676418498074623 0.6296919670559048 0.7827776506947461 0.1261873671970344 0.24376641672507487 1.11035561259779 0.06543291105074711 0.1538457440352414 1.6427798160480235e-07 6.784420641728305 -0.5379498827515575 TLVK(ub)NCIVLIDSTPYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLVKNCIVLIDSTPYR 16 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 25932900.0 4472100.0 4806800.0 16654000.0 True False 6784502.654303787 3948988.984300178 13362329.600292493 1.0 0.5820602018329397 1.9695370878535987 22.693811630440944 -6.825926188996196 1.3459515216174158 0.7759740985179243 2.003876017034319 0.8974885878575795 0.1860737323253484 0.18589407809408431 0.6600252925588642 0.10858699986560288 0.24998102547640896 1.4930481406813783e-07 6.825926188996196 1.2279019185163946 TLVK(ub)NCIVLIDSTPYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLVKNCIVLIDSTPYR 16 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 18440700.0 4472100.0 5507300.0 8461300.0 True False 5789221.608270115 5200813.913694224 6921430.220269553 1.0 0.8983615182850612 1.1955718209822952 22.464937952533393 -6.814412266818775 1.3959932626173754 0.9448904036481761 1.2013088542419383 0.8710226273989239 0.044295269071530065 0.20084049679361435 0.7705401463966974 0.02494430267559335 0.05759236625297043 1.5331608936897449e-07 6.814412266818775 0.2564184505937622 TLVQILTEPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLVQILTEPR 10 0 O76031 O76031 CLPX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial 0 3765100.0 1078000.0 1005500.0 1681600.0 False True 1413268.43936685 855483.319408303 1507604.1630462173 1.0 0.6053225951833772 1.0667500391656874 20.430604089745465 -6.680167630458886 1.9007597186161833 0.7503348669279752 1.0650207814196022 0.32519314608637406 0.167264984988661 0.43811185742627723 3.0602827885813286 0.07059909054068964 0.18619668510212964 2.0884898528536693e-07 6.680167630458886 0.314685914491627 TLVQILTEPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLVQILTEPR 10 0 O76031 O76031 CLPX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial 0 4572400.0 1078000.0 1571100.0 1923300.0 False True 1476565.7318546192 1501683.607067067 1469056.1516068701 1.0 1.0170110105297505 0.9949141578422541 20.493814151268356 -6.701061905129993 1.8268669512955116 1.0105520246074002 0.9949781014929697 0.42270441682278603 0.007179162143419848 0.3933246628664011 2.552756767038045 0.0031340621674424206 0.008050074590287535 1.9903896049899674e-07 6.701061905129993 -0.01557392311443051 TLVSTVGSMVFNEGEAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLVSTVGSMVFNEGEAQR 18 0 Q9P2E9;Q9P2E9-3;A0A087WVV2 Q9P2E9 RRBP1 Ribosome-binding protein 1 0 7072000.0 2626600.0 1325300.0 3120100.0 False True 2543220.0207281513 1854499.201348198 2302852.2090063784 1.0 0.7291933793511247 0.905486819951601 21.278224848136485 -10.648581911765152 6.021205598573795 1.0013985650016697 0.8173400996513629 0.588709775088911 0.071971495745137 0.0013610641922665756 7.943623890557737e-05 0.07019340835200555 0.023228700368546122 2.2460431125225192e-11 10.648581911765152 -0.1840584653503068 TLVSVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLVSVTK 7 0 P07900;P07900-2;Q58FG1 P07900;Q58FG1 HSP90AA1;HSP90AA4P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A4 0 46461000.0 13713000.0 17020000.0 15728000.0 False True 17977875.796880905 14480682.343440376 14100617.433629211 1.0 0.8054723765503331 0.784331674828659 24.09971923131815 -13.999999999712575 0.31342228031972574 2.9184963708028837 0.7798195447534374 0.9996794889566073 0.0017377916257854125 17.516969903467775 0.1782612995598333 21.957965328415337 0.007224756849165237 1.000000000661821e-14 13.999999999712575 -2.1386768260494464 TLVSVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLVSVTK 7 0 P07900;P07900-2;Q58FG1 P07900;Q58FG1 HSP90AA1;HSP90AA4P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A4 0 38658100.0 14919000.0 8574100.0 15165000.0 False True 14445404.51124771 11997782.84334082 11192831.559751846 1.0 0.8305605311363151 0.7748368383202219 23.784107268127908 -13.999999999990782 0.15545498472238264 1.8269557945021422 0.7172146600495062 0.9995490622320247 0.002033280581147849 11.982428119138685 0.1244279556168178 2.989406724816889 0.05223412612435993 1.0000000000212241e-14 13.999999999990782 -1.109741134452636 TLVSVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLVSVTK 7 0 P07900;P07900-2;Q58FG1 P07900;Q58FG1 HSP90AA1;HSP90AA4P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A4 0 157517000.0 28533000.0 102310000.0 26674000.0 False True 43286647.041714124 84051981.1483215 21401872.20837047 1.0 1.9417531015355143 0.49442203707175764 25.367418718778122 -6.731061153187009 1.7190205236379652 1.566055001676731 0.49505817698661986 0.5643449830254623 0.395858445255705 0.334244420733687 1.9354158995064854 0.1824400881652894 0.4522286941720172 1.8575428752890632e-07 6.731061153187009 -1.0709968246901111 TLVSVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLVSVTK 7 0 P07900;P07900-2;Q58FG1 P07900;Q58FG1 HSP90AA1;HSP90AA4P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A4 0 48741000.0 13713000.0 19047000.0 15981000.0 False True 18783066.679890905 18205440.559993915 12206616.939026348 1.0 0.9692475073564322 0.6498734816341102 24.162929292841042 -6.925586396223923 0.7821717346914108 1.0057324215267374 0.591115115775954 0.9955973917842413 0.010503638628265281 0.0949952488692031 0.08938829326783025 0.009329001952247345 0.029630021671102034 1.1868985622975514e-07 6.925586396223923 -0.41461730575078337 TLVSVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLVSVTK 7 0 P07900;P07900-2;Q58FG1 P07900;Q58FG1 HSP90AA1;HSP90AA4P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A4 0 32151100.0 14919000.0 12049000.0 5183100.0 False True 12405809.523762686 11984089.645460756 6266862.2460533 1.0 0.9660062588020437 0.5051554462487474 23.564512543562184 -6.921711724719845 0.8119513609516041 1.0095552481963908 0.4278376489698323 0.9946427740566594 0.016518698500029304 0.09717553317895261 0.10047912752621041 0.014362968705966234 0.043752451483600255 1.1975351654790752e-07 6.921711724719845 -0.5817175992265584 TLVSVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLVSVTK 7 0 P07900;P07900-2;Q58FG1 P07900;Q58FG1 HSP90AA1;HSP90AA4P Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-alpha A4 0 84222000.0 28533000.0 26508000.0 29181000.0 False True 36936530.96951566 25032806.49759527 23870357.42234481 1.0 0.6777248929590942 0.646253364779855 25.13854504087057 -13.999999999999988 0.3289264010293026 4.4855776887106495 0.640609479673336 0.9997126081454137 0.0027099915578385667 18.733374125290016 0.18334362446434935 45.146915838566784 0.010125887654341055 1.0000000000000286e-14 13.999999999999988 -3.8449682090373134 TLVSVTK(ub)EGLELPEDEEEKKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLVSVTKEGLELPEDEEEKKK 21 3 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 25620400.0 6364300.0 10666000.0 8590100.0 True False 9655108.392653475 8762568.966161638 6892262.969825426 1.0 0.9075578035798163 0.7138462552186069 23.202861024944 -6.9591223997913625 0.4476303249694535 1.0064003253464604 0.6073547062926853 0.9997362512948968 0.0019364147841117937 0.08001611830287443 0.022300957431019838 0.0025802038402548497 0.01602896101405441 1.0986961437379574e-07 6.9591223997913625 -0.3990456190537751 TLWIWECGITAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLWIWECGITAK 12 0 P13489;H0YCR7 P13489 RNH1 Ribonuclease inhibitor 0 4276900.0 1026600.0 1876600.0 1373700.0 False True 1345882.5416085406 1596618.5949295056 1231562.701460864 1.0 1.1862986149008934 0.9150595712378834 20.360121077316165 -6.721824959441923 1.7524504413496942 1.1131162474979985 0.9154289978649848 0.5212883541271733 0.07837777858495305 0.3517644575939429 2.1121572939607134 0.03549642809382363 0.08892865892681244 1.8974705346047675e-07 6.721824959441923 -0.19768724963301376 TLWIWECGITAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLWIWECGITAK 12 0 P13489;H0YCR7 P13489 RNH1 Ribonuclease inhibitor 0 4990900.0 1026600.0 1598500.0 2365800.0 False True 1406161.7628218464 1527872.9844673816 1807046.765180436 1.0 1.0865556331166968 1.2850916679416062 20.423331138839057 -6.957279439808085 0.47221799497418504 0.9948675635076516 1.384949188284127 0.999655601898933 0.0022147638363903834 0.08068768793975761 0.024833793719740187 0.0027566544648477995 0.01638381229288869 1.1033684467487356e-07 6.957279439808085 0.39008162477647534 TLWNGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLWNGQK 7 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 8625500.0 2111700.0 4201700.0 2312100.0 False True 2768459.1497318917 3574822.7380983178 2072866.0712292797 1.0 1.291268010382063 0.7487436003634094 21.400651803522617 -6.760861881142069 1.6090976454318846 1.1690020666296126 0.7466675502832875 0.6945296290590629 0.12252410774250062 0.2814697417476311 1.436525881991528 0.060071535241743565 0.14424616430818654 1.7343554878641895e-07 6.760861881142069 -0.42233451634632513 TLWNGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLWNGQK 7 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 5042800.0 1860800.0 1217800.0 1964200.0 False True 1801729.9225504235 1704073.890743103 1449717.0952630802 1.0 0.9457987400969151 0.8046250867671363 20.780951338189848 -6.954577211360986 0.5061063873680799 1.0026836630908427 0.7415876209187887 0.999513244997879 0.0018169205876035594 0.08169818555898319 0.02874638192993879 0.0021070829420533647 0.01164866672580142 1.1102551302687515e-07 6.954577211360986 -0.26109604217205395 TLWNGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLWNGQK 7 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 6870300.0 2111700.0 2464300.0 2294300.0 False True 2892452.5565467547 2355419.077649652 1752433.5925917139 1.0 0.8143328305656785 0.605864247842292 21.46386186504551 -6.969623837873176 0.2670169916448896 1.053734077063256 0.36022065763326294 0.9999792973735607 0.0007325066228718019 0.07642494186330584 0.00946599559171366 0.004162401980384138 0.019469509624025053 1.0724477987009654e-07 6.969623837873176 -0.693513419429993 TLWNGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLWNGQK 7 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 4921300.0 1860800.0 2233000.0 827500.0 False True 1547337.6474172284 2220970.3857842023 1000526.424072294 1.0 1.4353495434505728 0.6466115690666119 20.561356613624124 -6.756848943640583 1.6241504432821554 1.2538623366643273 0.6441524159333153 0.6780396198536636 0.1830368510289445 0.2882454067447321 1.4977962520120043 0.08894734217637248 0.2144402611841703 1.7504554263717987e-07 6.756848943640583 -0.609709920731012 TLWNGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLWNGQK 7 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 19160000.0 7870700.0 5321800.0 5967500.0 False True 10188776.304691657 5025637.151761829 4881476.231720725 1.0 0.4932522808894782 0.47910328833826066 23.2804774551496 TLWSLVAFPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLWSLVAFPK 10 0 Q93034 Q93034 CUL5 Cullin-5 0 2520110.0 522430.0 882280.0 1115400.0 False True 684910.7892193167 750647.2631005034 999989.107672306 1.0 1.0959781549887908 1.460028259756465 19.385556561294685 -6.946096912447472 0.6001750818917161 0.9959010887400417 1.5787465235710447 0.9988582234659877 0.006695517566369713 0.08509209461792949 0.042749265039303895 0.0068707070326176805 0.030595525433687144 1.1321476972414066e-07 6.946096912447472 0.582845434831003 TLWSLVAFPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLWSLVAFPK 10 0 Q93034 Q93034 CUL5 Cullin-5 0 2634630.0 522430.0 948300.0 1163900.0 False True 715586.4891398967 906400.9703912538 889010.7912729353 1.0 1.26665467298119 1.2423526782087333 19.448766622817576 -10.270916340131507 5.26196978944356 0.9999629098470206 1.2545036755948695 0.9932080051151512 0.00992124782083401 4.31774704011207e-06 5.982688769971771e-07 0.009607604935152126 0.003202068965290391 5.358998800902559e-11 10.270916340131507 0.2545407657478489 TLYGFGG ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLYGFGG 7 0 P62805 P62805 HIST1H4A Histone H4 0 911260000.0 165430000.0 617720000.0 128110000.0 False True 250969404.55300087 507483039.7316108 102789002.34739219 1.0 2.0220912610263544 0.4095678615904144 27.90293625638221 -6.735383519068858 1.703337507577665 1.61133652934508 0.4094753114205453 0.5842497737397809 0.4295092381731351 0.32618379107164625 1.8562834280745815 0.19962399629833796 0.4924129991524284 1.8391471603329318e-07 6.735383519068858 -1.201861217924535 TLYGFGG ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLYGFGG 7 0 P62805 P62805 HIST1H4A Histone H4 0 40805800.0 4417800.0 18913000.0 17475000.0 False True 6051180.046555973 18077361.123072647 13347764.908922205 1.0 2.987410882504045 2.205811892263738 22.528785080522244 -10.432807579137261 5.904588870711584 0.9992852384859507 2.5966113873838923 0.8476485412474482 0.3190864515938897 0.0030034054683361336 0.0002885055421315727 0.30906298460726594 0.10298470941862908 3.691411160029714e-11 10.432807579137261 1.5973261488979416 TLYGFGG ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLYGFGG 7 0 P62805 P62805 HIST1H4A Histone H4 0 34798700.0 12046000.0 18807000.0 3945700.0 False True 10016782.728282433 18705682.9581028 4770727.627144475 1.0 1.8674342316807189 0.4762734459313271 23.255915870621262 -6.7380762801562435 1.6936289344335709 1.5172535203493458 0.4757740117313036 0.5963623494302941 0.36447815536042416 0.3212880911174523 1.808744842400645 0.17029795883080595 0.4187994651908454 1.8277791539827752e-07 6.7380762801562435 -1.0414795086180422 TLYGFGG ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLYGFGG 7 0 P62805 P62805 HIST1H4A Histone H4 0 731570000.0 165430000.0 244640000.0 321500000.0 False True 214152396.11281607 231025568.94415691 262990298.868574 1.0 1.0787904928341405 1.2280520958076508 27.674062578474658 -6.961091944201151 0.4197659195605889 0.9933857192598212 1.319085186015399 0.9998085634296157 0.0013084908351719546 0.0793133989783028 0.019707355693794698 0.001930540126908424 0.012425686393850941 1.0937247899984867e-07 6.961091944201151 0.3256994667555777 TLYNNQPIDFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLYNNQPIDFLK 12 0 Q13867;K7ESE8;K7ES02;J3KSD8 Q13867 BLMH Bleomycin hydrolase 0 10734600.0 2122000.0 4201300.0 4411300.0 False True 2781962.5494772294 3574482.416539131 3954860.9921775484 1.0 1.2848779783936444 1.4216082789902127 21.407671567907723 -12.461474682698384 0.11214032590901214 1.2318528778504542e-22 1.6862869841683172 0.999779600121654 0.0026073321242483798 6.850378346393339 0.08642593468819315 1.782466966080027 0.20905993678341517 3.45561473580178e-13 12.461474682698384 1.6862869841683172 TLYNNQPIDFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TLYNNQPIDFLK 12 0 Q13867;K7ESE8;K7ES02;J3KSD8 Q13867 BLMH Bleomycin hydrolase 0 14926500.0 5056800.0 4139400.0 5730300.0 False True 4896274.65195238 5792284.006685836 4229362.524684866 1.0 1.1829981809488923 0.863791928624432 22.223253056255093 -6.751213088193064 1.6451990465096165 1.1074472701030935 0.8630924262867854 0.6542287395604731 0.07690240296951983 0.29793877779039757 1.5869784357610524 0.03691844748547521 0.08951965528653698 1.7733191817876629e-07 6.751213088193064 -0.24435484381630812 TLYNNQPIDFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLYNNQPIDFLK 12 0 Q13867;K7ESE8;K7ES02;J3KSD8 Q13867 BLMH Bleomycin hydrolase 0 10285600.0 2122000.0 3447800.0 4715800.0 False True 2906560.744893784 3295464.795650075 3602025.164949658 1.0 1.1338021410491812 1.2392740015076782 21.470881629430615 -6.973801561445952 0.14024296079094953 0.8592254495010923 1.5166023493197458 0.9999989129957227 0.00010191829462308236 0.07508728822640269 0.0042479759619672396 0.0059464914635444935 0.013720714643579808 1.0621807797372416e-07 6.973801561445952 0.6573768998186535 TLYNNQPIDFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLYNNQPIDFLK 12 0 Q13867;K7ESE8;K7ES02;J3KSD8 Q13867 BLMH Bleomycin hydrolase 0 7946800.0 5056800.0 2890000.0 0.0 False True 4204953.254223692 2874430.9963799147 0.0 1.0 0.6835821524276575 0.0 22.00365833168937 -7.462106066539576 0.7316097473630447 0.9919670659589905 2.2623912178693844e-17 0.9871788280382773 0.04725341416215634 0.11720118735505418 0.14095792126680992 0.04139921263011167 0.07470154033524959 3.450594561279941e-08 7.462106066539576 -0.9919670659589905 down TLYSFFSPSPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLYSFFSPSPAR 12 0 P13051 P13051 UNG Uracil-DNA glycosylase 0 7666500.0 1814600.0 3235600.0 2616300.0 False True 2378958.1726113986 2752861.092270015 2345590.3733217283 1.0 1.1571708674676615 0.9859737763892493 21.18189847551488 -6.665331581073163 1.95430349028114 1.1007248450451113 0.9866841692444237 0.2583439990742169 0.06683610549258788 0.4719468357451323 3.4705190143688656 0.027579513315381308 0.07412678387849315 2.1610679320855847e-07 6.665331581073163 -0.11404067580068755 TLYSFFSPSPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLYSFFSPSPAR 12 0 P13051 P13051 UNG Uracil-DNA glycosylase 0 6218100.0 1814600.0 1911500.0 2492000.0 False True 2485506.657721144 1827043.6095147976 1903440.9243510193 1.0 0.735078944101456 0.7658160634726296 21.245108537037773 -9.835150011141748 6.335392617963116 1.0000000104083326 0.750447503922552 0.9887500558308191 0.01254837643730613 1.8592325499288802e-09 3.143492881858384e-10 0.012149913783943901 0.00404997108026691 1.4616722060564915e-10 9.835150011141748 -0.24955250648578065 TLYVGNLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TLYVGNLSR 9 0 Q01085;Q01085-2;E7ETC0;E5RG67;P31483-2;C9JTN7;F8W8I6;P31483;P31483-3;E5RGV5 Q01085;P31483-2;F8W8I6 TIAL1;TIA1 Nucleolysin TIAR;Nucleolysin TIA-1 isoform p40 0 10749700.0 3368400.0 3681400.0 3699900.0 False True 4416005.019632 3132149.469984805 3317069.839946895 1.0 0.7092721715805064 0.7511472077591337 22.074310381339277 -10.553752058560994 6.900109180497722 1.000224836507308 0.73020968966982 0.9822523006616162 0.017095411933037017 5.9178023081861646e-05 3.827175232752111e-06 0.016566144190709564 0.005517520476100659 2.7941385771805637e-11 10.553752058560994 -0.27001514683748806 TLYVGNLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLYVGNLSR 9 0 Q01085;Q01085-2;E7ETC0;E5RG67;P31483-2;C9JTN7;F8W8I6;P31483;P31483-3;E5RGV5 Q01085;P31483-2;F8W8I6 TIAL1;TIA1 Nucleolysin TIAR;Nucleolysin TIA-1 isoform p40 0 18484000.0 6604900.0 5063400.0 6815700.0 False True 8550173.252043398 4781617.338913676 5575312.534987676 1.0 0.559242157785624 0.6520701242697319 23.027522222928727 -9.993121393544142 5.82421760971096 1.000000539007703 0.6056561410275805 0.9600989100108647 0.037896858624770484 2.652325344752244e-07 4.5907263521842265e-08 0.03669352533628541 0.012231158527218169 1.0159646717842428e-10 9.993121393544142 -0.39434439798012244 TLYVHWTDAGQLTPALLHSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TLYVHWTDAGQLTPALLHSR 20 0 A0A087WZ13;E9PAU2;Q8IY67-2;Q8IY67 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 0 126163000.0 44680000.0 32986000.0 48497000.0 False True 67782826.54553631 27099390.579205666 38911546.693009794 1.0 0.3997972932126159 0.5740620253843962 26.01441646270656 -10.882180864474131 11.214066567117413 1.0244875464029033 0.4869296592986894 0.92036794266623 0.07114327899727226 0.03260326816252206 0.00034254135593935695 0.05156276625610948 0.0229613945625853 1.3116535394806092e-11 10.882180864474131 -0.5375578871042139 TLYVHWTDAGQLTPALLHSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TLYVHWTDAGQLTPALLHSR 20 0 A0A087WZ13;E9PAU2;Q8IY67-2;Q8IY67 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 0 5330500.0 1701300.0 1076800.0 2552400.0 False True 2330316.5859037717 1029223.4154985789 1949575.6883280666 1.0 0.44166677683384936 0.8366140893135163 21.152094535313992 -9.838992258067448 5.671443643009459 1.0000000939178717 0.6391404330721457 0.526763165046441 0.16123656514859788 1.9139727501355525e-07 3.917231750653423e-08 0.15611667361300774 0.05203887763422007 1.4487976802462632e-10 9.838992258067448 -0.36085966084572596 TLYVHWTDAGQLTPALLHSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TLYVHWTDAGQLTPALLHSR 20 0 A0A087WZ13;E9PAU2;Q8IY67-2;Q8IY67 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 0 23090900.0 9437700.0 7342800.0 6310400.0 False True 7847865.711000422 7303242.878968324 7629875.464007005 1.0 0.930602427196391 0.972222989661016 22.90386892437122 -10.012570726930056 4.522843884608476 1.0000015482781905 0.9514127084251749 0.6450194098097999 0.016991523490118114 129185393649.52895 28212645430.63906 2342096.2875091173 0.005819126091792044 9.714697302097456e-11 10.012570726930056 -0.04858883985301565 TLYVHWTDAGQLTPALLHSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TLYVHWTDAGQLTPALLHSR 20 0 A0A087WZ13;E9PAU2;Q8IY67-2;Q8IY67 A0A087WZ13 RAVER1 Ribonucleoprotein PTB-binding 1 0 133205000.0 44680000.0 50877000.0 37648000.0 False True 57839140.77447026 48045650.22552263 30796450.30110126 1.0 0.8306771086532045 0.5324499964683875 25.78554278479901 -6.962452128965848 0.39937415102024504 1.0165075163730906 0.33574116912762736 0.9998506122779302 0.0023623374281839618 0.07883652059491494 0.017978004541018326 0.003837627902046836 0.024992403006054258 1.0903046669156106e-07 6.962452128965848 -0.6807663472454633 TMCPLLSMKPGEYSYFSPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TMCPLLSMKPGEYSYFSPR 19 1 E9PHA2;Q15003;Q15003-2;C9J470 E9PHA2 NCAPH Condensin complex subunit 2 0 6097520.0 943820.0 2702800.0 2450900.0 False True 1292775.7597764616 2583381.359035621 1872047.8978699525 1.0 1.998321317134166 1.4480840035194154 20.30204062149144 -10.30544360329393 5.004522580058808 0.9997582665111692 1.7232026603270374 0.6972764015273987 0.2246334426335069 0.0006060624355747093 8.411252144265147e-05 0.21757137684248698 0.07250013185994504 4.9494437934077607e-11 10.30544360329393 0.7234443938158682 TMDVSK(ub)LSAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TMDVSKLSAEK 11 1 P25789;H0YN18;H0YMZ1;H0YL69;P25789-2;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type 1 6566000.0 1752500.0 3298700.0 1514800.0 True False 2297544.471234141 2806546.818231887 1358063.0269876344 1.0 1.2215418910800593 0.5910932493324675 21.131661355890945 -6.8117446274002225 1.4071568496287559 1.1204910042802414 0.5796145593077539 0.8643450420023475 0.09618175499974627 0.20442830428070285 0.7974579478151604 0.05374006102070636 0.12421821300096544 1.542607265827438e-07 6.8117446274002225 -0.5408764449724875 TMDVSK(ub)LSAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TMDVSKLSAEK 11 1 P25789;H0YN18;H0YMZ1;H0YL69;P25789-2;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type 1 10316700.0 2866900.0 3966600.0 3483200.0 True False 2775891.8287617187 5550484.06554573 2570845.4262398696 1.0 1.9995318290272548 0.9261331438072221 21.40451991924696 -6.662213501173177 1.9652760048672961 1.6422167934207126 0.9306103048457035 0.24498655240776646 0.42535491355734084 0.47919778511875627 3.560279616230589 0.17473150224074785 0.4715793167906406 2.1766394632768923e-07 6.662213501173177 -0.7116064885750091 TMDVSK(ub)LSAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TMDVSKLSAEK 11 1 P25789;H0YN18;H0YMZ1;H0YL69;P25789-2;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type 1 21709500.0 5968400.0 9516200.0 6224900.0 True False 9054499.148486543 7817959.759590041 4994545.786529411 1.0 0.8634337064239285 0.5516092833654137 23.11020340972888 -6.957373753908344 0.47098864782419586 1.0081575088799548 0.3940808860236851 0.9996600544188342 0.0034599571675103195 0.0806529402200018 0.02470133633785494 0.004319529654376629 0.025734808496986995 1.1031288583865617e-07 6.957373753908344 -0.6140766228562697 TMDVSK(ub)LSAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TMDVSKLSAEK 11 1 P25789;H0YN18;H0YMZ1;H0YL69;P25789-2;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type 1 4531600.0 1752500.0 1225200.0 1553900.0 True False 2400446.609531743 1171066.6128054028 1186900.823575062 1.0 0.48785363863345566 0.4944499989552326 21.194871417413836 -9.953399258133116 7.086988298444806 1.0000000194688852 0.49115181879478076 0.9998739796114139 0.0026929528246520708 8.295107958416032e-10 1.2061338388898244e-10 0.0026074404770600073 0.0008691467868328688 1.113270604584014e-10 9.953399258133116 -0.5088482006741044 TMDVSK(ub)LSAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TMDVSKLSAEK 11 1 P25789;H0YN18;H0YMZ1;H0YL69;P25789-2;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type 1 6508000.0 2866900.0 2434700.0 1206400.0 True False 2383954.3752044546 2421583.7878498877 1458652.6622366358 1.0 1.01578445168113 0.6118626587019047 21.184925194681238 -6.897806541496486 0.9750458104302034 1.0178191775513283 0.5713055267587244 0.9854426178544251 0.022538320025987123 0.11303737509423527 0.18667223935916466 0.01740575764445086 0.04480769692965665 1.2652998556781392e-07 6.897806541496486 -0.44651365079260397 TMDVSK(ub)LSAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TMDVSKLSAEK 11 1 P25789;H0YN18;H0YMZ1;H0YL69;P25789-2;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type 1 19349200.0 5968400.0 8011300.0 5369500.0 True False 7726211.454752645 7565464.112501309 4392306.09572257 1.0 0.9791945453224096 0.5684941606174548 22.881329731821328 -6.917416226007368 0.8436645615452147 1.00993292693203 0.5060464963881625 0.9934326321074941 0.016101822201356454 0.09971612723616971 0.11366700625735641 0.013686790170359718 0.04003848579552718 1.209438457187187e-07 6.917416226007368 -0.5038864305438676 TMEDQDLK(ub)PNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TMEDQDLKPNR 11 1 Q6P1K8;Q13888;D6RJD3;D6RID8;D6RIT7;D6RGC9;R4GMS9 Q6P1K8 GTF2H2C;GTF2H2 General transcription factor IIH subunit 2-like protein;General transcription factor IIH subunit 2 1 8667000.0 1996800.0 3135000.0 3535200.0 True False 2617824.1370387054 2667270.2201342913 3169411.4160329336 1.0 1.0188882371416743 1.2107044820887725 21.319936750967845 -6.9259441610910075 0.7793517788610116 0.9966033043204431 1.246304396192665 0.9956795923979602 0.00625667928800138 0.09479888082778609 0.08839900589276922 0.005568187070647937 0.01775876913011676 1.1859212168093472e-07 6.9259441610910075 0.2497010918722219 TMEDQDLK(ub)PNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TMEDQDLKPNR 11 1 Q6P1K8;Q13888;D6RJD3;D6RID8;D6RIT7;D6RGC9;R4GMS9 Q6P1K8 GTF2H2C;GTF2H2 General transcription factor IIH subunit 2-like protein;General transcription factor IIH subunit 2 1 9904900.0 1870900.0 3028700.0 5005300.0 True False 1811509.3035788843 4238075.704461847 3694261.7742186603 1.0 2.3395274294694204 2.039328071305039 20.78876078455101 -10.04028852025429 4.845798182235379 0.9999734068536876 2.189427750405504 0.9544029823498371 0.12255587483197285 3.52111467945424e-05 6.973561310221235e-06 0.11866685708085153 0.039554738508039276 9.114051530665573e-11 10.04028852025429 1.1894543435518166 TMEDQDLK(ub)PNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TMEDQDLKPNR 11 1 Q6P1K8;Q13888;D6RJD3;D6RID8;D6RIT7;D6RGC9;R4GMS9 Q6P1K8 GTF2H2C;GTF2H2 General transcription factor IIH subunit 2-like protein;General transcription factor IIH subunit 2 1 45945300.0 7144300.0 12846000.0 25955000.0 True False 10838425.418291748 10553530.933743881 20824982.873519372 1.0 0.9737144028257964 1.9214029778138764 23.36965184468345 -6.90052265524772 0.9579787072708315 0.9611615440833075 2.021934073034395 0.9868239267336717 0.05058434391921358 0.11102095652436025 0.17526714157614987 0.03956426138779757 0.10320961874739501 1.2574112589991283e-07 6.90052265524772 1.0607725289510874 TMEDQDLK(ub)PNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TMEDQDLKPNR 11 1 Q6P1K8;Q13888;D6RJD3;D6RID8;D6RIT7;D6RGC9;R4GMS9 Q6P1K8 GTF2H2C;GTF2H2 General transcription factor IIH subunit 2-like protein;General transcription factor IIH subunit 2 1 9180200.0 1996800.0 1616900.0 5566500.0 True False 2735070.921491003 1545460.011626721 4251807.345666111 1.0 0.5650529935012526 1.5545510400689249 21.383146812490736 -6.787217260781964 1.507398316891163 0.7560280302785434 1.5642888918529787 0.7922022551588392 0.18459277522461712 0.23951982540645944 1.075208399451547 0.09640429349384909 0.22617541201302566 1.632235199289758e-07 6.787217260781964 0.8082608615744353 TMEDQDLK(ub)PNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TMEDQDLKPNR 11 1 Q6P1K8;Q13888;D6RJD3;D6RID8;D6RIT7;D6RGC9;R4GMS9 Q6P1K8 GTF2H2C;GTF2H2 General transcription factor IIH subunit 2-like protein;General transcription factor IIH subunit 2 1 12379700.0 1870900.0 4356200.0 6152600.0 True False 1555736.2449230938 4332732.285962 7439080.213591778 1.0 2.7850043991076285 4.781710420302974 20.569166059985285 -6.969674621872959 0.2658414593576084 0.4779314911231058 7.14847927331437 0.9999797330280263 0.006953983289463511 0.07640841332394895 0.00940720804570153 0.04016108953498609 0.18678971480288895 1.0723223999062356e-07 6.969674621872959 6.670547782191265 TMEDQDLK(ub)PNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TMEDQDLKPNR 11 1 Q6P1K8;Q13888;D6RJD3;D6RID8;D6RIT7;D6RGC9;R4GMS9 Q6P1K8 GTF2H2C;GTF2H2 General transcription factor IIH subunit 2-like protein;General transcription factor IIH subunit 2 1 56280300.0 7144300.0 10380000.0 38756000.0 True False 9248437.185206985 9802343.875246676 31702805.67014136 1.0 1.0598919232457644 3.427909498142073 23.1407781667759 -6.912333227260218 0.8796905021851363 0.9319804173822773 3.7497205507256535 0.991772776076739 0.10255682002687908 0.10289542994965611 0.13054597540569307 0.08494550237477883 0.23845924497736012 1.2236769310887208e-07 6.912333227260218 2.817740133343376 up TMEIYSK(ub)TTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TMEIYSKTTR 10 1 P35250;P35250-2;A0A087WVY3;H7C5P4 P35250 RFC2 Replication factor C subunit 2 1 10573780.0 839480.0 2711100.0 7023200.0 True False 1273552.534208747 2227283.023079016 5635061.441622085 1.0 1.7488740850905042 4.424679226226914 20.28042704152303 -6.947469597868042 0.5859657553070388 0.9686788976281867 5.338587339080755 0.9989874531678221 0.046777485759168215 0.08451802398851996 0.04029222343621896 0.048699903370673904 0.2239000114048178 1.1285749389535872e-07 6.947469597868042 4.369908441452568 TMGFCYQILTEPNADPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TMGFCYQILTEPNADPR 17 0 O95373 O95373 IPO7 Importin-7 0 3852300.0 1027000.0 1349400.0 1475900.0 False True 1346406.9454821488 1148074.7799200027 1323188.0258324856 1.0 0.8526952299023359 0.9827549020542609 20.360683093311156 -10.257553753177028 6.024933258537174 1.0000027674415597 0.9177250659815575 0.3479252200063334 0.05309663881431471 1.9738132425110353e-06 2.4325664968533954e-07 0.051412328483732304 0.01713686648895248 5.526450021406581e-11 10.257553753177028 -0.08227770146000224 TMGVMFTPLTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TMGVMFTPLTVK 12 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 24964600.0 7657900.0 8954400.0 8352300.0 False True 10039581.059209092 7618438.423977816 7488084.116918942 1.0 0.7588402722232703 0.7458562337170717 23.259195732662388 TMGVMFTPLTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TMGVMFTPLTVK 12 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 14353100.0 6615900.0 0.0 7737200.0 False True 6405881.8758605635 0.0 5710595.208975403 1.0 0.0 0.8914612101254589 22.610965764458093 -9.129050830579663 12.032804429234252 1.0000000065895842 0.4457306050627278 0.34012435566210475 0.3639375150485711 0.0 0.0 0.35238098371080406 0.11746032790360132 7.42932178736688e-10 9.129050830579663 -0.5542694015268563 TMGVMFTPLTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TMGVMFTPLTVK 12 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 22427000.0 3592300.0 11789000.0 7045700.0 False True 5449781.732308203 9685160.842122594 5653114.306759986 1.0 1.7771649063861747 1.0373102234987424 22.37776701939313 -10.168039226030958 3.9189076961300096 0.999794608737547 1.4072375643142025 0.28773049370656456 0.3020444101936657 213338635.83870375 325205723.3761376 568891.2460507803 0.11053694574113984 6.791422888500509e-11 10.168039226030958 0.40744295557665555 TMGVMFTPLTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TMGVMFTPLTVK 12 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 24437100.0 7657900.0 7277800.0 9501400.0 False True 10489232.57696613 6956242.731533768 7257365.007475439 1.0 0.6631793775656529 0.6918871284646961 23.32240579418528 -10.353637661240107 6.841310306432254 1.0000122044743092 0.6775332530151746 0.9940909731378644 0.011719890227596815 2.1817211601806127e-06 2.061279247938928e-07 0.011348163921738387 0.0037825783059051263 4.4295778492854505e-11 10.353637661240107 -0.3224789514591345 TMGVMFTPLTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TMGVMFTPLTVK 12 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 17356100.0 6615900.0 5408300.0 5331900.0 False True 5501413.984064721 5379164.414436503 6446775.638079833 1.0 0.9777785183986657 1.171839759151634 22.39137103989237 -6.878407892079388 1.088603947017707 0.9864960356409016 1.1851816216772204 0.9723799498729812 0.01441215809217972 0.12905146257686395 0.2808675365422789 0.010212314642476955 0.024599881815298066 1.3230982893088782e-07 6.878407892079388 0.1986855860363188 TMGVMFTPLTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TMGVMFTPLTVK 12 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 20643200.0 3592300.0 9588000.0 7462900.0 False True 4650303.16481938 9054419.371470638 6104728.775820458 1.0 1.9470600196497758 1.3127593104045656 22.14889334148558 -10.485403080334038 5.163708077005744 0.9986130845010988 1.6299096650271816 0.5680227679046261 0.2589521801894107 0.004142561717500272 0.0004128330046017178 0.2512124969703361 0.08357645677813537 3.270370221627106e-11 10.485403080334038 0.6312965805260828 TMGVMFTPLTVK(ub)YAYYDTER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TMGVMFTPLTVKYAYYDTER 20 1 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 1 10714500.0 3462600.0 2660200.0 4591700.0 True False 3352681.65833141 3722431.7327597328 3388996.021952692 1.0 1.110284874052833 1.010831438031416 21.676884073109004 -10.805811012152688 3.566421742196357 0.9877082755934711 1.0605581560430388 0.3308177693464721 0.04060169523942918 0.004732794690326788 0.00025769698565995797 0.04688741273290312 0.013104140790453377 1.5638280109309795e-11 10.805811012152688 0.07284988044956775 TMGVMFTPLTVK(ub)YAYYDTER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TMGVMFTPLTVKYAYYDTER 20 1 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 1 44274000.0 12056000.0 15331000.0 16887000.0 True False 18289833.411660388 12595063.26835027 13549277.048164964 1.0 0.6886373967911862 0.7408092104068504 24.124538598933707 -10.457803005642452 6.057902272101403 1.0001481459872714 0.7147233035990267 0.9755296025665579 0.021299053718994362 4.263810107510721e-05 3.816194827640557e-06 0.020633341201709534 0.006874240028636843 3.4849535538374144e-11 10.457803005642452 -0.2854248423882447 TMGVMFTPLTVK(ub)YAYYDTER ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TMGVMFTPLTVKYAYYDTER 20 1 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 1 59853800.0 19375100.0 19391800.0 21086900.0 True False 25081448.89031869 18312629.283237822 17249300.56986542 1.0 0.7301264517579924 0.6877314243406233 24.580117355513394 -13.999999999590626 0.2605365147220777 2.981140746552984 0.672315759596679 0.9995634294345306 0.002889661218087745 14.440925390095677 0.16152630074123167 15.067528159854405 0.018482316974358586 1.0000000009426181e-14 13.999999999590626 -2.308824986956305 TMLELLNQLDGFEATKNIK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TMLELLNQLDGFEATKNIK 19 1 P62195;P62195-2 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 8860600.0 0.0 8860600.0 0.0 True False 0.0 8367499.8209066065 0.0 0.0 TMLELLNQLDGFQPNTQVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TMLELLNQLDGFQPNTQVK 19 0 P17980;R4GNH3;E9PM69;E9PKD5 P17980 PSMC3 26S protease regulatory subunit 6A 0 20478900.0 5557900.0 14921000.0 0.0 False True 8431740.636916671 12258230.971694907 0.0 1.0 1.4538197389545786 0.0 23.007399059213316 -6.846420605150029 1.4144281748603988 1.2421833180431965 1.8911247551597856e-20 0.8899738466723475 0.20144938091300565 0.17801487380328623 0.7154543421959265 0.1144155478258125 0.24278710598419437 1.4242275907337172e-07 6.846420605150029 -1.2421833180431965 down TMMACGGSIQTSVNALSADVLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TMMACGGSIQTSVNALSADVLGR 23 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 26463700.0 5007700.0 21456000.0 0.0 False True 7597047.011908744 17627009.16350683 0.0 1.0 2.3202448445923296 0.0 22.857007318254865 -6.754843821402732 1.647960022629815 1.7740274640179765 1.817592422724176e-07 0.6589277349253959 0.5549526436841312 0.2940451120599789 1.5753058031680192 0.26660433654467414 0.6399384453953069 1.758555902480843e-07 6.754843821402732 -1.7740272822587342 TMMACGGSIQTSVNALSADVLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TMMACGGSIQTSVNALSADVLGR 23 0 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 0 5007700.0 5007700.0 0.0 0.0 False True 6482566.366524512 0.0 0.0 1.0 0.0 0.0 22.628133640347315 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 TMQTLLSLVR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TMQTLLSLVR 10 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 90890300.0 26229800.0 24563500.0 40097000.0 False True 34387521.809744515 20898721.54777307 35948147.07758328 1.0 0.6077414261893954 1.0453834759152818 25.035381813759937 -6.670423353282997 1.935673127680843 0.7497175435127724 1.0436256469218665 0.28101009843111635 0.166606016628181 0.4601454016089 3.3242260501865895 0.06927901173471446 0.18500746073310823 2.1358790046481375e-07 6.670423353282997 0.2939081034090941 TMQTLLSLVR ddPTM_RPMI8226_Bortezomib_2h_R1 2 TMQTLLSLVR 10 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 74243300.0 41014600.0 19191500.0 14037200.0 False True 39712613.97325693 26854766.032350346 10360436.213026615 1.0 0.6762276099587589 0.260885274890328 25.24309398962035 -7.258765677512782 0.36399256238273664 1.042638683235692 6.94440007756652e-12 0.999726382936857 0.0050039815482971995 0.09727345353268739 0.025194913659820958 0.010582069464069161 0.047424697204365665 5.5110496348990334e-08 7.258765677512782 -1.0426386832287475 down TMQTLLSLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TMQTLLSLVR 10 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 117297000.0 26229800.0 39655000.0 51412200.0 False True 35927665.89369227 37902910.9784511 39269697.22749585 1.0 1.054978386032743 1.093021109239115 25.09859187528283 -6.975053477660268 0.06425903725250001 0.8170186489782049 1.3319290326835889 0.9999999363455968 7.712356065272083e-06 0.07469552360918988 0.0018500491669253979 0.005991567095428298 0.008793683570369902 1.0591233000263255e-07 6.975053477660268 0.514910383705384 TMQTLLSLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TMQTLLSLVR 10 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 80429000.0 41014600.0 18217700.0 21196700.0 False True 34105457.15485736 18119557.634169664 25628831.96753257 1.0 0.5312803036738959 0.7514583912821843 25.023499265054625 -10.055145506316217 4.91488783020701 1.0000081431694579 0.6413693474746827 0.7796099369710171 0.08988732787529477 8.020736052673909e-06 1.541996421567775e-06 0.087035005402213 0.02901101032301889 8.807537352435338e-11 10.055145506316217 -0.3586387956947752 TMQTLLSLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TMQTLLSLVR 10 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 23645200.0 6527000.0 11478700.0 5639500.0 False True 8449330.166404827 10839900.254411753 4613168.866156523 1.0 1.2829301306643233 0.5459804239274292 23.010405543392366 -6.8026444417337055 1.4452040637571264 1.1555850186686474 0.535143726700595 0.8397518005495391 0.1215137499520184 0.2170052089426607 0.8945294687794266 0.06613924569152142 0.15356668832338155 1.5752720168614703e-07 6.8026444417337055 -0.6204412919680524 TMSAQIEGGVHGLHSYEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TMSAQIEGGVHGLHSYEK 18 0 P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4 P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 21943400.0 10594100.0 7986500.0 3362800.0 False True 13888967.693410348 6794945.3311331775 3014849.714255359 1.0 0.4892332879683387 0.2170679477990118 23.727436038264972 -9.01258639591444 0.2295064773691057 1.3490819238866538 1.2283837514540326e-26 0.9993544733809345 0.00824567017823934 0.47541415612370375 0.0767297578971558 0.2517077137524813 0.12303116945993152 9.714346810206079e-10 9.01258639591444 -1.3490819238866538 TMSAQIEGGVHGLHSYEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TMSAQIEGGVHGLHSYEK 18 0 P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4 P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 8179600.0 4128500.0 1379000.0 2672100.0 False True 3997443.027326648 1929641.8913899998 1972196.8487182923 1.0 0.4827190477009694 0.49336459212458855 21.930646041484056 -10.054546359351292 5.1529491530522336 1.0000068763812835 0.48804181991122664 0.9996758186712719 0.004346025317409556 3.433336237187211e-07 6.298658634971662e-08 0.004208077384918129 0.0014026736389326606 8.819696500695485e-11 10.054546359351292 -0.5119650564700569 TMSAQIEGGVHGLHSYEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TMSAQIEGGVHGLHSYEK 18 0 P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4 P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 8427900.0 4128500.0 2851200.0 1448200.0 False True 3433030.6735608503 2835840.0196811133 1751011.9242797515 1.0 0.8260456399417161 0.5100484355601592 21.711051316918333 -6.9618818121099375 0.408047328210359 1.0159016630109727 0.3085026423945063 0.999833749326975 0.0026149186161326834 0.07903562765117261 0.01869706136998033 0.004067162146122644 0.026400320373372067 1.0917373989021514e-07 6.9618818121099375 -0.7073990206164664 TMSCSDK(ub)ILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TMSCSDKILR 10 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 7439800.0 1117200.0 1069900.0 5252700.0 True False 1446237.4233043464 1010359.1244823147 4296762.497253366 1.0 0.6986122113849453 2.9709938548237624 20.46387298282092 -6.873492934033099 1.115517917187613 0.8253764612701984 3.1131784811435956 0.968043478210632 0.18014268015921586 0.13354659326916424 0.30848902200872547 0.12504763378046713 0.29797247160763457 1.3381569867777737e-07 6.873492934033099 2.2878020198733973 up TMTQK(ub)DVEDMFSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TMTQKDVEDMFSR 13 1 Q15717;Q15717-2;M0QZR9;M0R055 Q15717 ELAVL1 ELAV-like protein 1 1 3902800.0 1049900.0 1428200.0 1424700.0 True False 1376429.0672460615 1215118.127079998 1277285.7106874068 1.0 0.8828047561587666 0.9279706023957928 20.39249883347549 -10.55979390305661 8.376949374143656 1.0000194251108674 0.9053876794730207 0.8540312235782417 0.018438879513619617 6.69075717701029e-06 3.515793079122856e-07 0.01785703143975825 0.005951122773247826 2.75553604858451e-11 10.55979390305661 -0.09463174563784671 TMTQK(ub)DVEDMFSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TMTQKDVEDMFSR 13 1 Q15717;Q15717-2;M0QZR9;M0R055 Q15717 ELAVL1 ELAV-like protein 1 1 5989200.0 1730200.0 1575500.0 2683500.0 True False 1675275.7480635988 2204605.3661239613 1980610.8467256264 1.0 1.3159656663520611 1.1822596065244515 20.6759671500419 -10.154146908897319 4.329253388312257 0.9999469880379795 1.2491126364524228 0.8223286654927289 0.05458527040207365 5875761.945367928 13781443.380458307 1721.7088917377034 0.018685989781924317 7.012180570980345e-11 10.154146908897319 0.24916564841444322 TMTQK(ub)DVEDMFSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TMTQKDVEDMFSR 13 1 Q15717;Q15717-2;M0QZR9;M0R055 Q15717 ELAVL1 ELAV-like protein 1 1 5724100.0 1730200.0 2577800.0 1416100.0 True False 1438737.9608562393 2563912.879746765 1712199.9626933844 1.0 1.7820568786694817 1.1900707490017146 20.456372425476175 -10.259016078699787 4.939173675701487 0.9998936328692987 1.4860638138358617 0.4733740863193262 0.24167732541656523 0.0002831595005186964 4.247990347982417e-05 0.23405392408013048 0.07800102137432852 5.507873044639421e-11 10.259016078699787 0.48617018096656306 TMVQLGICAFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TMVQLGICAFR 11 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 5571000.0 3028500.0 1230000.0 1312500.0 False True 2932361.925217086 1721145.414365265 968716.8758440025 1.0 0.586948493487156 0.3303537900671273 21.48363174765662 -8.612016884677654 0.18536060501940888 1.3603294914799697 1.1676155335638087e-11 0.9997570254362824 0.004299970789275066 0.21044625594600977 0.04980282013080921 0.17631798139580668 0.1358226566491221 2.4433355578529403e-09 8.612016884677654 -1.3603294914682935 down TMVQLGICAFR ddPTM_RPMI8226_Bortezomib_8h_R1 2 TMVQLGICAFR 11 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 137913000.0 37106000.0 57248000.0 43559000.0 False True 56292514.81196668 47031647.119334444 34949544.55741205 1.0 0.8354866943932738 0.6208559819036983 25.746439764819307 -6.967472217986446 0.31272905594369993 1.0320179080780327 0.41747522388949115 0.9999554122239543 0.0010365513583684013 0.07713175424825724 0.011951838540270366 0.0033548393051316375 0.019005398560805135 1.0777741971898018e-07 6.967472217986446 -0.6145426841885415 TMVQLGICAFR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TMVQLGICAFR 11 0 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 0 112514500.0 37106000.0 40294700.0 35113800.0 False True 48034448.468609996 38052264.52311197 28723448.698013477 1.0 0.7921869769771318 0.5979760279080533 25.517566086911756 -6.971941461193507 0.2066325541303297 1.106152568623347 0.2786092467490477 0.9999938241959611 0.00040790818931879557 0.07567769629123786 0.0067273009704238275 0.005974281771540337 0.02028472662985273 1.0667398980331319e-07 6.971941461193507 -0.8275433218742994 TMYLLGYIPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TMYLLGYIPK 10 0 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 0 20168200.0 3530600.0 8800300.0 7837300.0 False True 4628650.79037904 7487329.543300729 7026371.376690114 1.0 1.6176051904506696 1.518017170639638 22.14216029160127 -10.079566314901307 4.3713622963978445 0.999946992207543 1.567811180592074 0.9774492084759798 0.040656639029210746 28466548.853486385 37547466.4461736 19506.56341706194 0.01487880273523256 8.325947826325581e-11 10.079566314901307 0.567864188384531 TMYLLGYIPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TMYLLGYIPK 10 0 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 0 10167000.0 3020400.0 1895000.0 5251600.0 False True 2924519.05528337 2651683.382294454 3876048.415377037 1.0 0.9067075071724983 1.3253626808738537 21.479767958598764 -6.848222754295692 1.2436256152885312 0.9502817208891756 1.3415351018231627 0.9376838888303555 0.04479767402485932 0.1594195641820604 0.4753568831209368 0.028199590231526784 0.06518621397479138 1.4183298585020598e-07 6.848222754295692 0.3912533809339871 TMYLLGYIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TMYLLGYIPK 10 0 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 0 13393500.0 3530600.0 4447100.0 5415800.0 False True 4835958.230877479 4250612.417406884 4136699.5819021882 1.0 0.8789597044628765 0.8554043241088104 22.205370353124163 -13.999999999999984 0.23012813882322175 1.7645449878878612 0.8439654511959844 0.9995099611713346 0.0014022492442852107 13.295338040029941 0.1518928955793549 4.64494351541471 0.012217686583964542 1.0000000000000368e-14 13.999999999999984 -0.9205795366918768 TMYLLGYIPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TMYLLGYIPK 10 0 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 0 8922400.0 3020400.0 2424100.0 3477900.0 False True 2511596.4264074555 2411040.892153826 4205112.810007282 1.0 0.9599634984361471 1.6742788633531396 21.26017323403304 -6.893631888904531 1.0006701125314295 0.9648932205748495 1.7402680040075058 0.9831221693372408 0.042573395167543514 0.11624526473135553 0.20504003311339133 0.03225299661998359 0.08153144627032421 1.2775211860857435e-07 6.893631888904531 0.7753747834326563 TNAAAMNMGRPFQK(ub)NR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNAAAMNMGRPFQKNR 16 2 Q71RC2-5;Q71RC2-3;Q71RC2;Q71RC2-4;Q96J85;Q71RC2-7;Q71RC2-6;Q71RC2-2;X6RLN4 Q71RC2-5 LARP4 La-related protein 4 1 7709700.0 1746200.0 1798300.0 4165200.0 True False 2260490.322747987 1698223.024167252 3407176.338561067 1.0 0.7512631251182667 1.5072731363959566 21.1082043107575 -6.818046775464267 1.3802068012027031 0.8656615841786506 1.5231102902993203 0.8798589182183466 0.10904399343443731 0.19602729329374724 0.7342695726178461 0.06209166356778688 0.14319796778906227 1.5203837687602979e-07 6.818046775464267 0.6574487061206697 TNADTDGMVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNADTDGMVK 10 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 4125200.0 833700.0 1464200.0 1827300.0 False True 1092988.7735622856 1245747.0674068977 1638228.5246993054 1.0 1.1397619971399522 1.4988521056442017 20.059847152027316 -6.954873264178591 0.502507755990652 0.9929622359297854 1.661205851080763 0.9995302861713125 0.004553780983334207 0.08158596726975542 0.028305961196307766 0.005315558041757564 0.029624485436345032 1.1094985419042075e-07 6.954873264178591 0.6682436151509776 TNADTDGMVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNADTDGMVK 10 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 3577620.0 1162600.0 736520.0 1678500.0 False True 1125693.899375066 1030616.2769010599 1238850.49607936 1.0 0.915538653512479 1.1005216398233244 20.102383149948515 -6.78257143962137 1.5259295718324148 0.9523354304877956 1.102104822678169 0.7763563977037591 0.03575850179509081 0.2466007323054391 1.1343087244137215 0.018454333440676016 0.043450419378667254 1.6497895955270286e-07 6.78257143962137 0.14976939219037333 TNADTDGMVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNADTDGMVK 10 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 5085800.0 833700.0 1875600.0 2376500.0 False True 1141941.419895359 1792729.7902202231 1815219.6455538534 1.0 1.56989645789755 1.5895908616049583 20.123057213550208 -11.421365578973303 0.5475740885673596 2.2356485697979674e-15 1.5878960539844833 0.999909109751531 0.00260660482017352 4.09077207057388 0.26982601573520004 4.90252855508792 0.0036935240333876088 3.789958208108787e-12 11.421365578973303 1.587896053984481 TNADTDGMVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNADTDGMVK 10 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 2274090.0 1162600.0 947170.0 164320.0 False True 966753.4119127634 942067.4072114762 198678.55227016212 1.0 0.9744650451737793 0.2055110949927428 19.882788425382792 -6.913961743139269 0.8683273930718113 1.0209311014013762 0.09723462522742936 0.9923323233271558 0.03228132496215521 0.1018568110405266 0.12499127810587664 0.026957978709340143 0.07662580096817158 1.219096984054867e-07 6.913961743139269 -0.9236964761739469 down TNCNVAVINVGAPAAGMNAAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNCNVAVINVGAPAAGMNAAVR 22 0 Q01813;Q01813-2;B1APP6 Q01813 PFKP ATP-dependent 6-phosphofructokinase, platelet type 0 11866200.0 3124800.0 5736100.0 3005300.0 False True 4096643.0606062496 4880296.239142671 2694340.384873211 1.0 1.1912915445507355 0.6576946892889624 21.96601076599239 -6.809743344657713 1.4155030840418983 1.1042836243390164 0.6484041688102592 0.8591879756760654 0.08282833851208032 0.20714703123013908 0.8180600842854874 0.04601036297190804 0.10644924499576074 1.5497321947675294e-07 6.809743344657713 -0.4558794555287572 TNDFTK(ub)IK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNDFTKIK 8 1 Q8IWI9-3;Q8IWI9;H3BP52;H3BTF4 Q8IWI9-3 MGA MAX gene-associated protein 1 7362300.0 1997900.0 3042800.0 2321600.0 True False 1934477.7580951713 4257805.9079923825 1713503.313492903 1.0 2.2010105260579116 0.8857704909360882 20.883512710630367 -6.666428641094319 1.9498732276829995 1.768927389585042 0.8911403405959761 0.2634159901547417 0.5105839675437431 0.4693545538643231 3.436747860783719 0.21106020535157685 0.5665721170840273 2.1556158035995932e-07 6.666428641094319 -0.8777870489890658 TNEAQAIETAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNEAQAIETAR 11 0 P61088;F8VQQ8;Q5JXB2 P61088 UBE2N;UBE2NL Ubiquitin-conjugating enzyme E2 N;Putative ubiquitin-conjugating enzyme E2 N-like 0 18688500.0 1957400.0 9967500.0 6763600.0 False True 2566170.355488566 8480387.853010694 6063767.553032455 1.0 3.304686235998598 2.3629637604000733 21.291185516392687 -10.523163808232528 6.291491370820261 0.9981662205461828 2.8338249981993355 0.8348750052847552 0.38445659075449473 0.0098918106691206 0.0007497059061330079 0.37235646265881145 0.12408283111098642 2.998031501001201e-11 10.523163808232528 1.8356587776531528 TNEAQAIETAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNEAQAIETAR 11 0 P61088;F8VQQ8;Q5JXB2 P61088 UBE2N;UBE2NL Ubiquitin-conjugating enzyme E2 N;Putative ubiquitin-conjugating enzyme E2 N-like 0 22483200.0 6928700.0 3594500.0 11960000.0 False True 6708752.211078638 5029802.595069868 8827317.20769087 1.0 0.749737423117789 1.3157912127256237 22.677613027807762 -6.78650887785652 1.5101187911637963 0.8594914596515413 1.321257074256764 0.789859861947489 0.1061706414590747 0.24059385496235108 1.083914085376403 0.055349400469945735 0.12993110640733135 1.634899730135119e-07 6.78650887785652 0.4617656146052227 TNEAQAIETAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TNEAQAIETAR 11 0 P61088;F8VQQ8;Q5JXB2 P61088 UBE2N;UBE2NL Ubiquitin-conjugating enzyme E2 N;Putative ubiquitin-conjugating enzyme E2 N-like 0 71285400.0 9974400.0 50105000.0 11206000.0 False True 15131894.026315982 41163371.27784821 8991129.188235728 1.0 2.720305284074862 0.594183991283523 23.85108924207389 -6.691440557809701 1.861033116506798 2.0770973170199296 0.6013714319643058 0.3771322379422608 0.7273643787460343 0.4136726177222215 2.7788583050785434 0.312514905857578 0.8124150398572683 2.0349767054789305e-07 6.691440557809701 -1.4757258850556239 TNEAQAIETAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNEAQAIETAR 11 0 P61088;F8VQQ8;Q5JXB2 P61088 UBE2N;UBE2NL Ubiquitin-conjugating enzyme E2 N;Putative ubiquitin-conjugating enzyme E2 N-like 0 15397200.0 1957400.0 6972400.0 6467400.0 False True 2681103.6767460424 6664336.313356515 4939933.320284024 1.0 2.485669006819153 1.8424999238669653 21.35439557791558 -10.530263442719544 5.855288669634492 0.9979320437271497 2.164084465343059 0.8137020744296845 0.26257267859444183 0.00709532454713874 0.0005692165083607963 0.25448748943871957 0.0847449676137787 2.949419568135329e-11 10.530263442719544 1.1661524216159094 TNEAQAIETAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNEAQAIETAR 11 0 P61088;F8VQQ8;Q5JXB2 P61088 UBE2N;UBE2NL Ubiquitin-conjugating enzyme E2 N;Putative ubiquitin-conjugating enzyme E2 N-like 0 12900900.0 6928700.0 3619800.0 2352400.0 False True 5761521.043454299 3600299.418925952 2844275.963731312 1.0 0.6248869685230561 0.4936675475589406 22.45801830324204 -13.999999999999988 0.14643541087263365 2.8046141805249425 0.34321146124067 0.9995785693912991 0.004404527596745418 11.946100954774513 0.12032177332073975 6.141515591257058 0.1351712884842678 1.0000000000000286e-14 13.999999999999988 -2.4614027192842727 TNEGVIEFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNEGVIEFR 9 0 A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247 A0A590UJK4 SRSF6 Serine/arginine-rich splicing factor 6 0 38893400.0 4412400.0 10858000.0 23623000.0 False True 5784699.129742382 9238028.7241525 21178718.56781683 1.0 1.5969765266882445 3.6611616426038758 22.46381049403005 -6.948222672071025 0.5780262529311069 0.9751391780605033 4.384751401539433 0.9990543290817426 0.03506093902416866 0.08420736627715297 0.03897715802361936 0.036813617132243764 0.17234139042269447 1.1266196660627663e-07 6.948222672071025 3.40961222347893 TNEGVIEFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNEGVIEFR 9 0 A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247 A0A590UJK4 SRSF6 Serine/arginine-rich splicing factor 6 0 10167700.0 6260400.0 3907300.0 0.0 False True 6061667.028769706 5467505.266300321 0.0 1.0 0.9019804684669427 0.0 22.53128317546553 -7.114545850490701 0.9741970825407815 0.9984377472130556 9.764846853826579e-19 0.9896091983077706 0.04587939036440622 0.08534279780232241 0.15374554534045234 0.038017409208405115 0.06701915572026634 7.681643527105418e-08 7.114545850490701 -0.9984377472130556 down TNEGVIEFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNEGVIEFR 9 0 A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247 A0A590UJK4 SRSF6 Serine/arginine-rich splicing factor 6 0 32934500.0 4412400.0 7971100.0 20551000.0 False True 6043783.5206264565 7618910.445097245 15697277.061130738 1.0 1.2606193486406545 2.5972599792097895 22.52702055555294 -6.939239689053529 0.6665977652171406 0.9847818811858028 2.9497896915753423 0.9980626298092654 0.03079611679108206 0.08811518042911143 0.05620177631366361 0.029807786551811963 0.11543269683778778 1.1501654323321767e-07 6.939239689053529 1.9650078103895394 up TNEGVIEFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNEGVIEFR 9 0 A0A590UJK4;A0A590UK01;A0A590UJP7;A0A590UK80;Q13247-3;Q13247 A0A590UJK4 SRSF6 Serine/arginine-rich splicing factor 6 0 10291900.0 6260400.0 4031500.0 0.0 False True 5205799.982744419 4009781.509309904 0.0 1.0 0.7702527032542668 0.0 22.311688450899805 -7.299079803632608 0.8191927353882262 0.9889936321771162 1.816908211746461e-18 0.9882955465950379 0.04626780136217584 0.10379803378059041 0.1375007034112353 0.03944564094162859 0.06980158697259387 5.022502902137262e-08 7.299079803632608 -0.9889936321771162 down TNEVK(ub)SGGAVEPLGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNEVKSGGAVEPLGTR 16 1 O75312;H7C0E5;H7BZM7 O75312 ZPR1 Zinc finger protein ZPR1 1 74726790.0 24361600.0 43421600.0 6943590.0 True False 31938293.518070024 36943266.53607113 6225133.9144184515 1.0 1.1567075903779704 0.19491128763333582 24.92878389496983 -6.865116459522592 1.1596885394006902 1.0864758777412584 0.14359027465358712 0.959557472820504 0.08473366694750264 0.14161933807046378 0.3590641323455724 0.05685962148928786 0.13358198530387894 1.3642172618161783e-07 6.865116459522592 -0.9428856030876713 down TNEVK(ub)SGGAVEPLGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNEVKSGGAVEPLGTR 16 1 O75312;H7C0E5;H7BZM7 O75312 ZPR1 Zinc finger protein ZPR1 1 104336400.0 50471300.0 42895100.0 10970000.0 True False 48869116.208092816 60023337.12499139 8096627.907054256 1.0 1.2282468311766075 0.16567985131094798 25.542419678071116 -6.850503766669135 1.232599566173634 1.1218614697563056 0.1227767702492748 0.9410362236293454 0.11089979607107332 0.15691088433654682 0.45848973846682717 0.07039184908506373 0.16294991087627175 1.4108999995618227e-07 6.850503766669135 -0.9990846995070308 down TNEVK(ub)SGGAVEPLGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TNEVKSGGAVEPLGTR 16 1 O75312;H7C0E5;H7BZM7 O75312 ZPR1 Zinc finger protein ZPR1 1 241331300.0 169611000.0 64958200.0 6762100.0 True False 257312287.22504392 53365901.689266935 5425567.971066283 1.0 0.2073974090580191 0.0210855378481056 27.9389451096622 -9.937103997363803 0.3748920719734502 1.3992325078012242 9.369817041495135e-19 0.9985631357358797 0.01608812715469602 1.371376218989056 0.17797913968824494 0.6661804039041791 0.05120485474718038 1.1558354294855437e-10 9.937103997363803 -1.3992325078012242 TNEVK(ub)SGGAVEPLGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNEVKSGGAVEPLGTR 16 1 O75312;H7C0E5;H7BZM7 O75312 ZPR1 Zinc finger protein ZPR1 1 75510600.0 24361600.0 42877600.0 8271400.0 True False 33368741.86748564 40983125.85473798 6317865.674830271 1.0 1.2281891243454932 0.1893348481617874 24.99199395649272 -6.849125551953546 1.2392575984238723 1.1216877816547235 0.14849056691900683 0.9390289848647387 0.1100730141783202 0.1584220238982229 0.4686210205595576 0.06951733592015709 0.16078444550136067 1.415384541546927e-07 6.849125551953546 -0.9731972147357166 down TNEVK(ub)SGGAVEPLGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNEVKSGGAVEPLGTR 16 1 O75312;H7C0E5;H7BZM7 O75312 ZPR1 Zinc finger protein ZPR1 1 140863100.0 50471300.0 86724800.0 3667000.0 True False 41969122.207700506 86257596.2888749 4433752.745707676 1.0 2.055263292427125 0.10564320892311085 25.322824953505393 -6.75971056903961 1.6135744366020541 1.6131839512326425 0.098628593448163 0.6897608903091565 0.4438284283232755 0.28341379309636905 1.4542730917399804 0.21703067462131528 0.5217049768025822 1.7389593537172752e-07 6.75971056903961 -1.5145553577844795 TNEVK(ub)SGGAVEPLGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNEVKSGGAVEPLGTR 16 1 O75312;H7C0E5;H7BZM7 O75312 ZPR1 Zinc finger protein ZPR1 1 286974300.0 169611000.0 113629000.0 3734300.0 True False 219564783.03264725 107305446.26208146 3054695.7171536987 1.0 0.48871884088135453 0.013912503066120097 27.71007143175465 -7.974383410045631 0.5595362203897682 1.0164401795369031 1.1043715793954228e-23 0.9909381546276458 0.03833073598263782 0.10915761714342687 0.15078895329301337 0.04404811832128742 0.07674290772609743 1.060758669610918e-08 7.974383410045631 -1.0164401795369031 TNFFGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TNFFGTR 7 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 15039200.0 3478100.0 8964700.0 2596400.0 False True 5276531.983169878 7364879.243479199 2083220.4019574542 1.0 1.395780271392337 0.39480863730232885 22.331158594639625 -6.799419644380789 1.4581828429123702 1.2185299641980833 0.38117145443696177 0.8304961715719323 0.1694653998295945 0.22158123985818218 0.9302057010446826 0.09142823787866552 0.21271329274326756 1.5870125298143354e-07 6.799419644380789 -0.8373585097611216 down TNFFGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNFFGTR 7 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 5351360.0 3018200.0 1622100.0 711060.0 False True 2509767.028930934 1613361.4253383593 859739.3584300247 1.0 0.6428331421763838 0.3425574360167769 21.259122020430425 -7.564259638962684 0.23491184497759607 1.1554756341756904 1.1867016031077243e-14 0.999878027699418 0.0029679276693816204 0.12979982662867148 0.025149507164034177 0.0324888430390445 0.07042537906583402 2.727346776123191e-08 7.564259638962684 -1.1554756341756787 down TNFFGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNFFGTR 7 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 10280600.0 3478100.0 3335500.0 3467000.0 False True 4502469.013600835 3149876.492859851 2836041.574424093 1.0 0.6995887108483947 0.6298858617032388 22.102284916732074 -13.99999999999943 0.20524689815210304 2.704342809254439 0.5868880807943582 0.9994878997571157 0.0036339907199691825 12.639610443397563 0.14362613166652222 8.667917431121232 0.04270767955671486 1.000000000001313e-14 13.99999999999943 -2.117454728460081 TNFFIQLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNFFIQLVR 9 0 H7C2P7;A6NJD9;A8MVT4;A8MYK1;Q16540 H7C2P7 MRPL23 39S ribosomal protein L23, mitochondrial 0 9462300.0 2228000.0 4056000.0 3178300.0 False True 2920929.5759826913 3450860.610164172 2849440.0044063935 1.0 1.1814254744581425 0.9755250615543354 21.47799614433299 -6.67408083157656 1.9230863659070236 1.1153967322270648 0.9763444803197519 0.29714553118449016 0.07699431737352005 0.45182945830308735 3.2253202666912415 0.03218904793368846 0.08554044992846756 2.1179668992092136e-07 6.67408083157656 -0.13905225190731296 TNFFIQLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNFFIQLVR 9 0 H7C2P7;A6NJD9;A8MVT4;A8MYK1;Q16540 H7C2P7 MRPL23 39S ribosomal protein L23, mitochondrial 0 11228000.0 4914800.0 2651900.0 3661300.0 False True 4758782.364225503 3710817.4994758097 2702295.693354396 1.0 0.7797829813298783 0.5678544397552414 22.18216104583724 -6.971593199113077 0.2167874322069158 1.1017846983741748 0.23989068392461138 0.9999922835315999 0.0004900723623860065 0.07578908622119286 0.007150986050755789 0.006017287991272713 0.02162878606329304 1.0675956631118992e-07 6.971593199113077 -0.8618940144495635 TNFFIQLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNFFIQLVR 9 0 H7C2P7;A6NJD9;A8MVT4;A8MYK1;Q16540 H7C2P7 MRPL23 39S ribosomal protein L23, mitochondrial 0 13520600.0 2228000.0 3538000.0 7754600.0 False True 3051751.809436077 3381679.4613985647 5923123.191000179 1.0 1.1081109056582994 1.9408928251261344 21.541206205855882 -6.93080665620752 0.740139385617542 0.987707819859835 2.115425435219059 0.9966944939200336 0.02416927339554495 0.09222088375878308 0.07564346693254145 0.02212607372551447 0.07502076665731891 1.1727173320079683e-07 6.93080665620752 1.127717615359224 TNFFIQLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNFFIQLVR 9 0 H7C2P7;A6NJD9;A8MVT4;A8MYK1;Q16540 H7C2P7 MRPL23 39S ribosomal protein L23, mitochondrial 0 9497500.0 4914800.0 1823000.0 2759700.0 False True 4086873.962557066 1813179.1371628335 3336740.510588891 1.0 0.44365917661634163 0.816453000792118 21.962566321271517 -10.070352663045714 5.605579692557617 1.0000022746975024 0.6300560887041369 0.5676657702710417 0.1521924414156212 4.326582057955197e-06 7.17644101277332e-07 0.14736060450651384 0.04911989925172464 8.504471634482794e-11 10.070352663045714 -0.3699461859933655 TNGKEPELLEPIPYEFMA ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNGKEPELLEPIPYEFMA 18 1 P46778 P46778 RPL21 60S ribosomal protein L21 0 5842360.0 569660.0 3024100.0 2248600.0 False True 746829.7765952869 2572916.067849472 2015936.44209427 1.0 3.4451171451399643 2.699325208061063 19.51041992434955 -9.963800311987725 5.534001209447698 0.9999961796278206 3.072221176603771 0.9114558166296386 0.3044682833656676 1.4352538866754594e-05 2.686213271647831e-06 0.294800682933166 0.0982667159086342 1.0869252755024319e-10 9.963800311987725 2.0722249969759505 TNGKEPELLEPIPYEFMA ddPTM_RPMI8226_Bortezomib_2h_R1 2 TNGKEPELLEPIPYEFMA 18 1 P46778 P46778 RPL21 60S ribosomal protein L21 0 12605700.0 6926100.0 2187300.0 3492300.0 False True 6706234.746655455 3060700.296618814 2577561.863245723 1.0 0.4563962360764737 0.38435306257825363 22.677071553784266 -13.999999999999998 0.2848419575710055 5.550774166422106 0.36368041628371905 0.9996159365956784 0.005385720867209794 15.66630455295669 0.16914645614073187 41.65050040162187 0.027858428805292733 1.0000000000000041e-14 13.999999999999998 -5.187093750138387 TNGKEPELLEPIPYEFMA ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNGKEPELLEPIPYEFMA 18 1 P46778 P46778 RPL21 60S ribosomal protein L21 0 8719660.0 569660.0 3554300.0 4595700.0 False True 780278.6964826548 3397259.273501674 3510290.3114125147 1.0 4.353904942959305 4.498764771146801 19.57362998587244 -10.193675817056144 0.6706086071341705 1.6506709246723016e-12 4.476138962648503 0.9998146557465246 0.02200412011092503 1.4863751526085087 0.33204282364828086 2.9173620352484515 0.023173173930099693 6.40212549463893e-11 10.193675817056144 4.476138962646853 TNHFAIVNLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNHFAIVNLR 10 0 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 0 14124600.0 4398900.0 2550200.0 7175500.0 False True 5767000.499008194 2169720.1006017416 6433048.092256255 1.0 0.3762302605964555 1.1154928967602151 22.459389716553023 -6.6830376432863865 1.8912123648076495 0.6064084457058246 1.112739989932059 0.33800160977727367 0.26419573200256696 0.4318254647584934 2.9887319412120674 0.11199020139091793 0.2942094651690584 2.074733678239583e-07 6.6830376432863865 0.5063315442262343 TNHFAIVNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNHFAIVNLR 10 0 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 0 8797400.0 2571200.0 1779400.0 4446800.0 False True 2489578.6634037215 2489923.6994484146 3282049.6788595133 1.0 1.0001385921440302 1.3183153145971838 21.247470170391722 -6.906987908154319 0.9159849627443544 0.989185630763904 1.3568936288582132 0.9897347196348667 0.015199948962057366 0.10644446216479315 0.14981451621295752 0.012261938865763936 0.033182810116966055 1.2388310782089694e-07 6.906987908154319 0.3677079980943092 TNHFAIVNLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNHFAIVNLR 10 0 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 0 13296800.0 4398900.0 3462900.0 5435000.0 False True 6025292.205802672 3309897.6277210535 4151364.9373386 1.0 0.5493339600249509 0.6889898108743371 22.522599778075914 -10.81716225534662 10.659980358666697 1.004282463198824 0.6191618854496462 0.9083845988365739 0.05701426236253813 0.005803918513216516 9.954738459880516e-05 0.05521470248712171 0.01840127405220088 1.52348346376464e-11 10.81716225534662 -0.38512057774917785 TNHFAIVNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNHFAIVNLR 10 0 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 0 7147200.0 2571200.0 2737600.0 1838400.0 False True 2138066.723473331 2722852.0054289466 2222800.9401987973 1.0 1.273511240568592 1.0396312312404423 21.027875445825998 -12.295550322155444 10.548984951053525 1.0053916002448955 1.140912588872058 0.0 0.12609080529267624 0.0 0.0 0.0 0.034962888499864155 5.063486749744859e-13 12.295550322155444 0.13552098862716244 TNHIGHTGYLNTVTVSPDGSLCASGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNHIGHTGYLNTVTVSPDGSLCASGGK 27 0 P63244;J3KPE3;D6RAC2;H0Y8W2;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 311894500.0 92152500.0 136307000.0 83435000.0 False True 120812819.90607943 115970526.9205245 74801946.56503399 1.0 0.9599190467591158 0.6191557040319516 26.84819831172209 -6.928981941845199 0.7551040255826619 1.0053825401971 0.5509790104835748 0.9963342871380138 0.010345335133061172 0.09317004191121729 0.0802959133003918 0.009368621977653523 0.031007653538491227 1.1776549399110524e-07 6.928981941845199 -0.45440352971352516 TNHIGHTGYLNTVTVSPDGSLCASGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNHIGHTGYLNTVTVSPDGSLCASGGK 27 0 P63244;J3KPE3;D6RAC2;H0Y8W2;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 190095000.0 107271000.0 36990000.0 45834000.0 False True 103865740.82217665 51760299.900301754 33828700.40947356 1.0 0.498338523276101 0.3256964244580895 26.630144631855558 -13.999999999999998 0.14883470894677298 3.4214951379848504 0.1331873619493554 0.999570175979529 0.005929368850167602 11.953545456179608 0.12143922762498659 8.374087800547503 0.1733249907715901 1.0000000000000041e-14 13.999999999999998 -3.288307776035495 TNHIGHTGYLNTVTVSPDGSLCASGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TNHIGHTGYLNTVTVSPDGSLCASGGK 27 0 P63244;J3KPE3;D6RAC2;H0Y8W2;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 994435000.0 196330000.0 594467000.0 203638000.0 False True 297846963.64559424 488379719.2581295 163388860.0422938 1.0 1.6397001778377995 0.5485664787125677 28.149996010925815 -6.747833049076713 1.658116638144472 1.3771313332162674 0.546782819811157 0.6395013540218182 0.26878091308259683 0.30383396332754464 1.6429018777270135 0.1280964750594039 0.3116637399887993 1.7871744661145093e-07 6.747833049076713 -0.8303485134051104 TNHIGHTGYLNTVTVSPDGSLCASGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNHIGHTGYLNTVTVSPDGSLCASGGK 27 0 P63244;J3KPE3;D6RAC2;H0Y8W2;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 335190100.0 92152500.0 115606600.0 127431000.0 False True 126223769.57767418 110498718.15209688 97334422.32382622 1.0 0.8754192536145057 0.7711259349129932 26.91140837324498 -6.9731739728437505 0.16565591427511223 1.0977177476972921 0.5460458229295928 0.9999977356589087 0.0001406676915804583 0.07528560217191327 0.005143506494652321 0.004575796831391119 0.012263927516165729 1.0637168214409303e-07 6.9731739728437505 -0.5516719247676993 TNHIGHTGYLNTVTVSPDGSLCASGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNHIGHTGYLNTVTVSPDGSLCASGGK 27 0 P63244;J3KPE3;D6RAC2;H0Y8W2;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 184842400.0 107271000.0 19155000.0 58416400.0 False True 89200589.41105619 19051808.213030174 70630999.15308362 1.0 0.2135838825597351 0.7918221126051112 26.410549907289834 -10.201828949504423 7.265524729381305 1.0000007897403487 0.5027029975890593 0.4965213198549291 0.23606476889687472 3.0197349985663726e-06 3.318979504945038e-07 0.22856909063050035 0.07618957654699154 6.283057735441542e-11 10.201828949504423 -0.49729779215128933 TNHIGHTGYLNTVTVSPDGSLCASGGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNHIGHTGYLNTVTVSPDGSLCASGGK 27 0 P63244;J3KPE3;D6RAC2;H0Y8W2;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 595300000.0 196330000.0 216970000.0 182000000.0 False True 254153055.2428772 204895428.76804173 148877867.47769958 1.0 0.8061891232125334 0.5857803571766111 27.921122333018264 -6.9694499584391485 0.2710006750334292 1.0541316434553674 0.3312028015072619 0.9999777682634342 0.0007978635590044881 0.0764816050320119 0.00966701339545759 0.004294201777449799 0.020471153418301434 1.0728772629447954e-07 6.9694499584391485 -0.7229288419481055 TNHIYVSSDDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNHIYVSSDDIK 12 0 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 3616300.0 1199900.0 1142800.0 1273600.0 False True 1573080.519848128 972298.6945995112 1141820.0892338606 1.0 0.6180857764950144 0.725849741845444 20.585161087892462 -10.284228269756648 8.165624633677663 1.0000004690220474 0.6719677591702303 0.9251187923752829 0.04399445462791987 3.7563422652585977e-07 3.295955689033861e-08 0.04259750782296333 0.01419914917495095 5.197227529737221e-11 10.284228269756648 -0.3280327098518171 TNHLVTVEGGWPQFGVGAEICAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNHLVTVEGGWPQFGVGAEICAR 23 0 P11177-2;P11177;P11177-3;C9J634 P11177-2 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 42139000.0 15435000.0 11499000.0 15205000.0 False True 19980911.769336395 10859070.541566629 12437846.01647486 1.0 0.5434722232361512 0.6224864090317709 24.25211908193082 -10.773126153272784 7.067629214750838 1.0103919576678164 0.582979316133961 0.9737809179007555 0.03225740627345579 0.005263168363399437 0.0001689496626430892 0.03112145603960401 0.010411033107411745 1.6860631888975877e-11 10.773126153272784 -0.4274126415338554 TNIIPVLEDAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNIIPVLEDAR 11 0 A6NHQ2 A6NHQ2 FBLL1 rRNA/tRNA 2-O-methyltransferase fibrillarin-like protein 1 0 18760600.0 2777100.0 8206100.0 7777400.0 False True 3640804.9934746586 6981781.867127273 6972669.254088753 1.0 1.9176478497586606 1.9151449381622272 21.79582603944435 -10.046405593351443 4.678260086651482 0.9999683328281009 1.9163963939895619 0.999994405039031 0.001021809480373419 353746.7071812645 0.005125989663327521 120.7571112047647 0.00034979254867247754 8.986579210069682e-11 10.046405593351443 0.9164280611614609 TNIIPVLEDAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNIIPVLEDAR 11 0 A6NHQ2 A6NHQ2 FBLL1 rRNA/tRNA 2-O-methyltransferase fibrillarin-like protein 1 0 9559600.0 0.0 2936600.0 6623000.0 False True 0.0 4109199.694166694 4888237.614258917 0.0 TNIIPVLEDAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNIIPVLEDAR 11 0 A6NHQ2 A6NHQ2 FBLL1 rRNA/tRNA 2-O-methyltransferase fibrillarin-like protein 1 0 14612600.0 2777100.0 6394000.0 5441500.0 False True 3803868.918305627 6111491.937869526 4156329.7712103017 1.0 1.6066515616399824 1.0926585170189493 21.85903610096724 -10.249304275685114 4.389502059982567 0.99982280179516 1.3496550393351212 0.38158095530125713 0.20983678179597146 0.0003640629258714213 6.226204665477074e-05 0.203275885814478 0.067724530107125 5.632428979452969e-11 10.249304275685114 0.3498322375399612 TNIIPVLEDAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNIIPVLEDAR 11 0 A6NHQ2 A6NHQ2 FBLL1 rRNA/tRNA 2-O-methyltransferase fibrillarin-like protein 1 0 20293600.0 7005300.0 4161600.0 9126700.0 False True 9068498.945107361 3930003.3016595957 7465734.247850112 1.0 0.4333686672346047 0.8232601991841247 23.112432339078374 -10.117836896806974 5.971267522888806 1.0000020069835316 0.6283144332093723 0.5478633430267645 0.15917255138476244 4.252843530055921e-06 6.284404590238617e-07 0.15411899140207821 0.051372720057205744 7.623652693920416e-11 10.117836896806974 -0.3716875737741593 TNIQK(ub)EATWTMSNITAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNIQKEATWTMSNITAGR 18 1 P52292 P52292 KPNA2 Importin subunit alpha-1 1 26725300.0 6501600.0 9395700.0 10828000.0 True False 8523660.56158396 7993898.1841517445 9707622.429510254 1.0 0.9378480203892857 1.1389029818083556 23.023041711028768 -6.82368099805787 1.355791427273889 0.9666188840576966 1.143651481180562 0.8926556707512875 0.0275377572354286 0.18874219875686485 0.6806775410777012 0.015956454378394228 0.036747471377919096 1.5007868023435714e-07 6.82368099805787 0.17703259712286545 TNIQK(ub)EATWTMSNITAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNIQKEATWTMSNITAGR 18 1 P52292 P52292 KPNA2 Importin subunit alpha-1 1 47820000.0 13231000.0 13020000.0 21569000.0 True False 12810989.147283226 18218953.898403015 15919431.843869954 1.0 1.422134831974831 1.2426387737004618 23.610878535893235 -10.424899124814763 5.223768203680021 0.9996708073681246 1.3323868028376549 0.820534694470526 0.07327895893554234 0.0002812147290645203 3.0959676861177776e-05 0.07102119376689088 0.023650682298726848 3.759247115713025e-11 10.424899124814763 0.33271599546953023 TNIQK(ub)EATWTMSNITAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TNIQKEATWTMSNITAGR 18 1 P52292 P52292 KPNA2 Importin subunit alpha-1 1 142836000.0 23187000.0 48353000.0 71296000.0 True False 35176374.19676259 39724029.36628669 57204314.3498531 1.0 1.1292815212871665 1.6262140614571305 25.068103448956332 -6.945791258241768 0.6032927453813246 0.9944408292691314 1.7866367582775322 0.9988281546334832 0.009240584121828432 0.08522126336313704 0.04330668994437618 0.009453479830733563 0.04180625187735168 1.1329447773810905e-07 6.945791258241768 0.7921959290084009 TNIQK(ub)EATWTMSNITAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNIQKEATWTMSNITAGR 18 1 P52292 P52292 KPNA2 Importin subunit alpha-1 1 27136400.0 6501600.0 8459800.0 12175000.0 True False 8905417.21913357 8086018.063182462 9299515.75199586 1.0 0.9079886842145246 1.044253797791254 23.08625177255166 -6.724830341708981 1.742017317227944 0.9443111296499779 1.0440999029696698 0.5351378633561894 0.038697675292697714 0.3460323433723023 2.0546711616718767 0.017621529532528546 0.04398592675824916 1.8843850857517621e-07 6.724830341708981 0.09978877331969194 TNIQK(ub)EATWTMSNITAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNIQKEATWTMSNITAGR 18 1 P52292 P52292 KPNA2 Importin subunit alpha-1 1 45206000.0 13231000.0 13971000.0 18004000.0 True False 11002162.732683431 13895735.449973632 21768553.15890947 1.0 1.2630003561658334 1.978570367282698 23.39128381132751 -6.953623895594192 0.5175345552781078 0.9876047654640887 2.2857651251710864 0.999455834163059 0.009645766541854716 0.08206242141565918 0.030186676520394418 0.010970808436379964 0.05909267782164592 1.1126949177481601e-07 6.953623895594192 1.2981603597069977 TNIQK(ub)EATWTMSNITAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TNIQKEATWTMSNITAGR 18 1 P52292 P52292 KPNA2 Importin subunit alpha-1 1 159436800.0 25990000.0 41743800.0 91703000.0 True False 33644567.33949158 39420720.83425068 75013994.95223898 1.0 1.1716816101831429 2.2296020095995845 25.003870232787897 -6.9352736312473775 0.7021595970627423 0.9866187702295666 2.4791513120782107 0.9974769397966785 0.027310623895145766 0.0899904565126581 0.06493419895168055 0.025714328018741926 0.09310497001381615 1.1607170629040521e-07 6.9352736312473775 1.4925325418486441 up TNIQVTVTGPSSPSPVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNIQVTVTGPSSPSPVK 17 0 Q6YHK3;Q6YHK3-2 Q6YHK3 CD109 CD109 antigen 0 9413000.0 2344500.0 3082500.0 3986000.0 False True 3073662.2041702983 2622603.0154908905 3573566.9564118776 1.0 0.853250240684413 1.1626414091839097 21.55152719071378 -6.777738140666404 1.5448204671345414 0.9166619565026521 1.1649146900120293 0.7592552429320318 0.062001412945472456 0.2541066744731058 1.197651932071251 0.03161724626597992 0.07474145904885872 1.6682527880502923e-07 6.777738140666404 0.24825273350937715 TNIQVTVTGPSSPSPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNIQVTVTGPSSPSPVK 17 0 Q6YHK3;Q6YHK3-2 Q6YHK3 CD109 CD109 antigen 0 11187600.0 3286700.0 3278000.0 4622900.0 False True 3182365.5075486214 4586922.494544178 3412023.8059727564 1.0 1.4413562752813671 1.072165908623438 21.601668113869458 -10.227338661706979 6.008057365288508 0.9999941475788807 1.256761091952404 0.392062539239048 0.15072133604383064 1.1815567865970616e-05 1.5195278017765746e-06 0.14593863235804272 0.048645102034656676 5.924631431819965e-11 10.227338661706979 0.2567669443735232 TNIQVTVTGPSSPSPVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNIQVTVTGPSSPSPVK 17 0 Q6YHK3;Q6YHK3-2 Q6YHK3 CD109 CD109 antigen 0 9892700.0 2344500.0 3566900.0 3981300.0 False True 3211325.0077302004 3409302.563839046 3040998.937447322 1.0 1.061649803626939 0.9469608121654224 21.614737252236672 -6.760661060225139 1.6097019582212877 1.0357787910532865 0.946523612209904 0.6938113726580557 0.025932730342593767 0.2817857075920489 1.4391491690839426 0.012709554143163233 0.030526571508336896 1.7351576518642372e-07 6.760661060225139 -0.08925517884338252 TNIQVTVTGPSSPSPVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNIQVTVTGPSSPSPVK 17 0 Q6YHK3;Q6YHK3-2 Q6YHK3 CD109 CD109 antigen 0 5943700.0 3286700.0 2657000.0 0.0 False True 2733036.675497744 2642686.213626796 0.0 1.0 0.9669413650094931 0.0 21.382073389303734 -7.050410474078203 1.0505456234855515 1.0124036657428468 1.897912414064917e-19 0.9878628560711366 0.05109722917216262 0.08523225322250114 0.18112721731990758 0.040748006368521335 0.07298193560986466 8.904089689353593e-08 7.050410474078203 -1.0124036657428468 down TNIVTASVDAINFHDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNIVTASVDAINFHDK 16 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 74221500.0 26768900.0 26848400.0 20604200.0 False True 35094287.130396344 22842723.37424351 18472275.03344248 1.0 0.6508957794004785 0.5263613124497126 25.064732862848306 -13.999999999999998 0.14355203125219004 2.6735821883529116 0.37864479118733313 0.9995891598414528 0.004063485637033032 11.939337219305203 0.1189544139514899 5.587039215217129 0.13239734817044013 1.0000000000000041e-14 13.999999999999998 -2.2949373971655787 TNIVTASVDAINFHDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNIVTASVDAINFHDK 16 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 57901800.0 21872100.0 14847700.0 21182000.0 False True 21177782.157682236 20776464.03973264 15633798.753621062 1.0 0.9810500403223753 0.7382169972859932 24.336048175276908 -6.922468627473255 0.8062089010853756 1.004896325015697 0.6967450116298376 0.9948395656306108 0.008562184642961617 0.0967409998217328 0.09824749506158846 0.007475319389286369 0.022948939109019666 1.195449879358355e-07 6.922468627473255 -0.30815131338585944 TNIVTASVDAINFHDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TNIVTASVDAINFHDK 16 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 153196300.0 21065300.0 90569000.0 41562000.0 False True 31957600.179715455 74406254.3311732 33347252.48272823 1.0 2.3282804063116513 1.043484250857323 24.929655738972556 -6.638446644911791 2.050264310605869 1.8696658512700166 1.0488367528297948 0.14855119232948633 0.5685589198655883 0.5373426384228438 4.315131269689725 0.22598756176037482 0.6295100457714503 2.2990761440651835e-07 6.638446644911791 -0.8208290984402218 TNIVTASVDAINFHDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNIVTASVDAINFHDK 16 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 73591800.0 26768900.0 18891100.0 27931800.0 False True 36666085.73232198 18056428.737486262 21334884.11347829 1.0 0.49245585878203285 0.5818696947700396 25.127942924371197 -10.835264136357447 7.396582623663287 1.0279863236780795 0.5371627767760409 0.9727714212582981 0.03650304568591998 0.014559025227016353 0.0003242565848482351 0.030544928792943956 0.011781307335618043 1.4612881538827494e-11 10.835264136357447 -0.49082354690203867 TNIVTASVDAINFHDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNIVTASVDAINFHDK 16 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 47455700.0 21872100.0 11799300.0 13784300.0 False True 18187620.248320263 11735734.828922316 16666533.39859783 1.0 0.6452595044701455 0.916366911725963 24.116453450711184 -9.782505789389797 5.773727852077827 1.0000000204801982 0.7808132080967636 0.4656791822430679 0.11067913554884905 2.921961613120935e-08 6.084683028016576e-09 0.10716462176758669 0.035721537395443745 1.6500390052252948e-10 9.782505789389797 -0.21918681238343463 TNIVTASVDAINFHDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNIVTASVDAINFHDK 16 0 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 0 92634500.0 21065300.0 43724000.0 27845200.0 False True 27269446.109141648 41290720.963514976 22777659.315879345 1.0 1.5141752714101853 0.8352813337210945 24.700782061065006 -6.7041885200865385 1.8162191400810657 1.3179667475565526 0.837153121864184 0.4373708289972269 0.21687816388582848 0.3868591057797088 2.483807671480949 0.09516770307492552 0.24346275881688886 1.9761116563618289e-07 6.7041885200865385 -0.48081362569236863 TNLANVVLLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNLANVVLLLK 11 0 Q92620;Q92620-2 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 0 5864400.0 1156700.0 2184800.0 2522900.0 False True 1516444.9014987338 1858836.356283698 2261854.5093656597 1.0 1.2257856216513845 1.491550736284729 20.53226164936432 -6.968972713763512 0.2816419490839411 0.9425961214258706 1.7828569116148216 0.9999732240883693 0.0010395286236040645 0.07663743827529876 0.010217880153944427 0.004863027088892276 0.024343750352424965 1.0740568920144508e-07 6.968972713763512 0.8402607901889511 TNLANVVLLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNLANVVLLLK 11 0 Q92620;Q92620-2 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 0 8188300.0 3619400.0 2027100.0 2541800.0 False True 3504504.1281593954 2836531.6011868515 1876026.3276345038 1.0 0.8093959936855972 0.5353186239845618 21.740778893030726 -6.965950201719402 0.3413570525596441 1.0292641715159156 0.30632341533095914 0.9999314074379685 0.001579568584190675 0.07764003172016709 0.013731509666553251 0.0038531418779843888 0.023699146663302202 1.0815579607921164e-07 6.965950201719402 -0.7229407561849566 TNLANVVLLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TNLANVVLLLK 11 0 Q92620;Q92620-2 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 0 28528800.0 6229800.0 11072000.0 11227000.0 False True 9451062.059386358 9096115.09406915 9007978.529031085 1.0 0.9624436954188983 0.9531181228552803 23.17204503005628 -13.999999999995946 0.19564330742868802 1.205405575278781 0.9467948903585431 0.9994872017744496 0.0004588234316021713 12.448105441341054 0.14026460526354306 0.9767267655703754 0.006136880938814871 1.0000000000093338e-14 13.999999999995946 -0.25861068492023775 TNLANVVLLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNLANVVLLLK 11 0 Q92620;Q92620-2 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 0 10951200.0 1156700.0 2796700.0 6997800.0 False True 1584363.2486421496 2673132.546549846 5345063.764214913 1.0 1.6871967642778931 3.373635287738342 20.59547171088721 -6.955858130471123 0.49034001180921777 0.9632070187513437 4.169178170517221 0.9995843883467316 0.02033036772127584 0.08121532418288789 0.026861751850372182 0.024298949262386724 0.13909231045091525 1.1069853401266023e-07 6.955858130471123 3.2059711517658775 TNLANVVLLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNLANVVLLLK 11 0 Q92620;Q92620-2 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 0 6426600.0 3619400.0 1216700.0 1590500.0 False True 3009691.466606791 1210145.3956039592 1923066.196358892 1.0 0.4020828742848882 0.638957919007894 21.521184168465002 -10.265931346771968 5.612846327358357 1.0000363542837898 0.520520396646392 0.8452758607243968 0.09670383206175566 4.3996413016398124e-05 5.75400799961837e-06 0.09364016104688865 0.031211027590796105 5.4208657662033796e-11 10.265931346771968 -0.47951595763739774 TNLANVVLLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNLANVVLLLK 11 0 Q92620;Q92620-2 Q92620 DHX38 Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16 0 19627300.0 6229800.0 7014200.0 6383300.0 False True 8064598.907716991 6623853.60402266 5221604.898189013 1.0 0.8213494161109878 0.6474723613585388 22.94317135214873 -6.971457175283108 0.22062981066967113 1.0795494458697534 0.3843589607639794 0.9999916236078392 0.0004165024861157381 0.07583269514031446 0.007314875017175924 0.004793123477004678 0.017599882355879615 1.0679300933224088e-07 6.971457175283108 -0.695190485105774 TNLATGIPSSK(ub)VK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNLATGIPSSKVK 13 1 Q5JWB9;A0A087WTT2;Q96A57;Q96A57-2 Q5JWB9 TMEM230 Transmembrane protein 230 1 2470730.0 816130.0 1654600.0 0.0 True False 1069954.3334141623 1407740.129580284 0.0 1.0 1.315701133793502 0.0 20.029117791779687 -6.878621726149861 1.342924313120545 1.1649585652231293 5.114323529416356e-18 0.9289786400204573 0.14945931011939623 0.1499303035506761 0.5435641406082292 0.09025166665546713 0.1842076523358045 1.3224469942444162e-07 6.878621726149861 -1.1649585652231293 down TNLATGIPSSK(ub)VK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNLATGIPSSKVK 13 1 Q5JWB9;A0A087WTT2;Q96A57;Q96A57-2 Q5JWB9 TMEM230 Transmembrane protein 230 1 1512500.0 730710.0 781790.0 0.0 True False 707514.0110204313 1093962.8239809913 0.0 1.0 1.5462065866415757 0.0 19.43239919259977 -6.829678934635497 1.4536939926322323 1.296006463505172 4.218046810281407e-21 0.862348200266567 0.23753614102312992 0.19511521434214502 0.8268675103780944 0.13071790493284502 0.28340072261459026 1.4802022681861179e-07 6.829678934635497 -1.296006463505172 down TNLCQK(ub)IR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNLCQKIR 8 1 P11766;D6RFE4;H0YAG8 P11766 ADH5 Alcohol dehydrogenase class-3 1 1732430.0 592270.0 445510.0 694650.0 True False 492498.7470097818 443109.9492031892 839898.1033012917 1.0 0.8997179219105472 1.7053811982279217 18.90976052857928 -6.875711082240053 1.1034019957945536 0.9407592621966763 1.7579906830760033 0.9700598799067904 0.062032347493311886 0.13149885927015129 0.2957999804737328 0.04345998301022234 0.10404647145588378 1.331339807533747e-07 6.875711082240053 0.817231420879327 TNLDESDVQPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNLDESDVQPVK 12 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 9970300.0 2644600.0 1495300.0 5830400.0 False True 2560648.620580851 2092381.0878864853 4303243.331749235 1.0 0.8171293285104673 1.6805286352694102 21.288077865162602 -6.8513523361810424 1.2285015982982268 0.9022875832980246 1.7159639648062694 0.9422573590636176 0.08926706023881634 0.15597434605548385 0.45229986895344354 0.056837872841563324 0.13164856427627883 1.4081459285732316e-07 6.8513523361810424 0.8136763815082448 TNLEEFASK(ub)HK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNLEEFASKHK 11 1 D6RJ86;D6RFY6;Q96H20-2;Q96H20;H0Y8S5;D6RBI1 D6RJ86 SNF8 Vacuolar-sorting protein SNF8 1 3455700.0 1028400.0 733000.0 1694300.0 True False 995754.0049176987 1025690.7225445033 1250512.0020895202 1.0 1.0300643707973627 1.2558443108575574 19.925429851550284 -6.931291031260605 0.7361078442309804 0.9967259196101906 1.3037589970699215 0.9967861679287351 0.0064730238560813625 0.09197262120056404 0.07443377210285092 0.005943228257406177 0.020286032491497 1.1714101121550611e-07 6.931291031260605 0.30703307745973085 TNLEEFASK(ub)HK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNLEEFASKHK 11 1 D6RJ86;D6RFY6;Q96H20-2;Q96H20;H0Y8S5;D6RBI1 D6RJ86 SNF8 Vacuolar-sorting protein SNF8 1 3377500.0 1028400.0 1110500.0 1238600.0 True False 855160.1658447314 1104517.5160830088 1497585.5333606554 1.0 1.2915914002986342 1.7512339713360399 19.70583512698456 -6.964419479046116 0.36788277373338935 0.963793748040884 2.0949779297709967 0.999900669347505 0.0030820007626568423 0.07815854080207843 0.015558154208934288 0.00607864429910392 0.039082068928835666 1.0853767667213575e-07 6.964419479046116 1.1311841817301127 TNLIFLSGNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNLIFLSGNR 10 0 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3;K7EQ85;L7N2F4 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 0 31955700.0 7523700.0 10118000.0 14314000.0 False True 9863643.559614442 8608433.839655092 12832924.589583442 1.0 0.8727438078664296 1.301032880195142 23.233689235643606 -6.827090109710737 1.3408331579139783 0.9318539409603258 1.3118901495804907 0.8999356792407339 0.056806997700788266 0.18442812812614093 0.6494777336518847 0.03327421286916678 0.0765897958634661 1.48905208927202e-07 6.827090109710737 0.38003620862016485 TNLIFLSGNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNLIFLSGNR 10 0 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3;K7EQ85;L7N2F4 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 0 18889700.0 0.0 4899700.0 13990000.0 False True 0.0 6856175.761597957 10325599.308996268 0.0 TNLIFLSGNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNLIFLSGNR 10 0 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3;K7EQ85;L7N2F4 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 0 27464900.0 7523700.0 8089200.0 11852000.0 False True 10305415.210347492 7731792.396592785 9052801.699602056 1.0 0.7502650052206944 0.8784509420360174 23.296899297166497 -10.103439456847271 4.898627053009164 1.0000075294034372 0.8143579736272665 0.7365975985484632 0.0523316895701284 4.303476740240169e-06 7.876073435985057e-07 0.05067199508311285 0.016889980181463527 7.880622842165108e-11 10.103439456847271 -0.1856495557761707 TNLIFLSGNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNLIFLSGNR 10 0 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3;K7EQ85;L7N2F4 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 0 10902800.0 0.0 4709900.0 6192900.0 False True 0.0 4684526.833858052 7487806.757265636 0.0 TNLIFLSGNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNLIFLSGNR 10 0 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3;K7EQ85;L7N2F4 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 0 26235700.0 7919300.0 9617200.0 8699200.0 False True 10251689.962740872 9081994.365801757 7116034.861329695 1.0 0.8859021682093098 0.6941328587962063 23.289358417834688 -6.963297822001017 0.3861544628871079 1.012294320105251 0.5608925014889239 0.9998736395830435 0.0014186564524702862 0.07854344511110692 0.01692682436733854 0.0024821592391589915 0.016158293746399068 1.088183604073942e-07 6.963297822001017 -0.4514018186163271 TNLIVNYLPQNMTQDELR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TNLIVNYLPQNMTQDELR 18 0 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 0 19347780.0 3757980.0 7016900.0 8572900.0 False True 4926748.172330087 5970005.871661972 7685858.545063569 1.0 1.2117538105948047 1.5600266699705438 22.232204300398752 -6.963681796117029 0.38000094759256636 0.9760772670502523 1.8080189793037917 0.9998833345753604 0.0024938037929015215 0.07841121594818203 0.01645526311901241 0.00453242553745252 0.029428707220901913 1.0872219301437367e-07 6.963681796117029 0.8319417122535394 TNLIVNYLPQNMTQDELR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TNLIVNYLPQNMTQDELR 18 0 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 0 23509380.0 3757980.0 7936200.0 11815200.0 False True 5147406.761590928 7585552.442496124 9024693.101682264 1.0 1.4736648556897083 1.753250426801897 22.295414361921644 -9.65905588992167 0.1136450294154598 1.6801282320593272e-17 2.42176261290504 0.999907718595917 0.0029865711429553914 1.160090563930133 0.04803172498399314 0.6857921265471913 0.3357146997784484 2.192522758588847e-10 9.65905588992167 2.42176261290504 TNLLLQAHLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNLLLQAHLSR 11 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 16548900.0 5995600.0 6105800.0 4447500.0 False True 7860289.661472995 5194838.440221984 3987315.36343247 1.0 0.6608965653879588 0.5072733366272991 22.90615104789846 -13.999999999998456 0.1067405092912034 2.646524409377914 0.21175701767815203 0.9997596329550169 0.0031914586085383116 12.032820412324934 0.09859203215839202 4.297154780271602 0.26273880479230066 1.0000000000035544e-14 13.999999999998456 -2.4347673916997623 TNLLLQAHLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNLLLQAHLSR 11 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 9765600.0 3628500.0 2342600.0 3794500.0 False True 3513315.2536404813 3278012.396497612 2800606.6174400547 1.0 0.9330254075836065 0.7971407104836603 21.744401606305072 -6.959763233622644 0.4387576596261621 1.0049220739095917 0.7199570082780724 0.999761313103057 0.0013038422086140786 0.07978580704412402 0.02144462409805916 0.0017888332540339472 0.01126158347574288 1.097076131323606e-07 6.959763233622644 -0.28496506563151924 TNLLLQAHLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNLLLQAHLSR 11 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 19669000.0 5995600.0 4994000.0 8679400.0 False True 8212335.344997733 4773348.56705043 6629504.477854031 1.0 0.5812413115786795 0.8072617835671031 22.969361109421353 -10.066342890330992 5.110027343837174 1.0000051802522414 0.6942515475719014 0.7092937266034272 0.09227247130255466 5.44570999611759e-06 9.948605108885893e-07 0.08934395020242233 0.029780812055188424 8.583355686509388e-11 10.066342890330992 -0.30575363268033995 TNLLLQAHLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNLLLQAHLSR 11 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 9015100.0 3628500.0 3055400.0 2331200.0 False True 3017258.5198051427 3038939.9537505833 2818643.1417490374 1.0 1.0071858058575773 0.934173562937215 21.524806881739348 -6.882706561271644 1.0645450227987707 1.0046359011361277 0.9287220396475957 0.9758056459960497 0.005110566392946509 0.12526153682663038 0.2580040555707766 0.0036885050381010713 0.008984706676140123 1.3100667937673794e-07 6.882706561271644 -0.07591386148853196 TNLWQGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNLWQGK 7 0 J3KQJ1;Q8NBJ7;C9J660;C9JL30;Q8NBJ7-3;A8MXB9;F8WA42;A0A494C1B1;Q8NBJ7-2;H7C3B2 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 5014800.0 1029300.0 2217200.0 1768300.0 False True 1349422.2677553801 1886402.4025779078 1585333.2787313422 1.0 1.3979333583369251 1.17482371279405 20.36391044338441 -10.09309851673666 4.157843235064921 0.9999533910052177 1.28637853542343 0.6871834487211492 0.0910841316175912 63859973.18732726 105228243.69929078 40104.1793844032 0.033333381690382954 8.070519352639604e-11 10.09309851673666 0.2864251444182123 TNLWQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNLWQGK 7 0 J3KQJ1;Q8NBJ7;C9J660;C9JL30;Q8NBJ7-3;A8MXB9;F8WA42;A0A494C1B1;Q8NBJ7-2;H7C3B2 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 4482080.0 1773800.0 883180.0 1825100.0 False True 1717491.6899290308 1235838.379722856 1347051.5581736309 1.0 0.7195600345372981 0.7843132901733533 20.711871687915043 -10.138575146809945 7.2317037378446 1.000000146215383 0.7519366623553261 0.9513801705584273 0.02643540591538907 6.233584254097284e-08 7.41016620463574e-09 0.025595986971375106 0.008531990571711244 7.268166258535979e-11 10.138575146809945 -0.24806348386005683 TNLWQGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TNLWQGK 7 0 J3KQJ1;Q8NBJ7;C9J660;C9JL30;Q8NBJ7-3;A8MXB9;F8WA42;A0A494C1B1;Q8NBJ7-2;H7C3B2 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 14273500.0 3755400.0 7855000.0 2663100.0 False True 5697216.356515379 6453213.878604873 2136737.1177218053 1.0 1.1326959474208715 0.37504931952921483 22.441825764113556 -6.861700892636431 1.1771496629897085 1.0723440377611488 0.33715786079918575 0.9556693863527259 0.0695553557020983 0.1450615693035958 0.3809994598519732 0.04605349858201359 0.1077140300592665 1.374988631369901e-07 6.861700892636431 -0.7351861769619631 down TNLWQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNLWQGK 7 0 J3KQJ1;Q8NBJ7;C9J660;C9JL30;Q8NBJ7-3;A8MXB9;F8WA42;A0A494C1B1;Q8NBJ7-2;H7C3B2 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 4256300.0 1029300.0 1368600.0 1858400.0 False True 1409860.0257866052 1308130.726645017 1419484.194949412 1.0 0.9278443978260678 1.00682632955526 20.4271205049073 -11.185525268072428 9.02512999223439 2.54336088152539 0.9673353636906576 0.18570397110571313 0.03224423860597626 0.04933647206732254 0.0010141879257300468 0.0015382685996763554 0.010406783261007024 6.523410854588015e-12 11.185525268072428 -1.5760255178347322 TNLWQGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNLWQGK 7 0 J3KQJ1;Q8NBJ7;C9J660;C9JL30;Q8NBJ7-3;A8MXB9;F8WA42;A0A494C1B1;Q8NBJ7-2;H7C3B2 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 4219180.0 1773800.0 1558200.0 887180.0 False True 1474993.2926637356 1549805.6673215174 1072685.23614315 1.0 1.0507204846489002 0.7272475349402808 20.49227696334932 -6.866814113348155 1.1507393083197346 1.0282039059247023 0.7094099096902575 0.9614029197933731 0.02790714109743691 0.13995032844820693 0.34835287666000464 0.018854399926235152 0.044410260382372814 1.3588949561223677e-07 6.866814113348155 -0.3187939962344448 TNLWQGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNLWQGK 7 0 J3KQJ1;Q8NBJ7;C9J660;C9JL30;Q8NBJ7-3;A8MXB9;F8WA42;A0A494C1B1;Q8NBJ7-2;H7C3B2 J3KQJ1 SUMF2 Sulfatase-modifying factor 2 0 8548700.0 3755400.0 2860400.0 1932900.0 False True 4861439.330001023 2701216.2255063183 1581132.0332288223 1.0 0.555641249873574 0.3252394868884417 22.212952086206005 -9.953855468335087 0.15490301113351052 1.6879725798804666 4.58489846365378e-12 0.9997161219916807 0.0047184337907632875 1.49030466919698 0.07039928840353712 0.6117990097671702 0.19011076866963061 1.1121017692325796e-10 9.953855468335087 -1.6879725798758816 TNNIELHYCTGAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNNIELHYCTGAYR 14 0 Q9NVM9;Q9NVM9-2;H0YH12 Q9NVM9 ASUN Protein asunder homolog 0 24418110.0 10642900.0 11650310.0 2124900.0 False True 13952944.965990208 9912129.16055269 1905035.7314800818 1.0 0.7103969222779235 0.13653287790667393 23.73406631955814 -7.285614342295331 0.5515802879712466 1.0053530125932382 6.440552533611593e-27 0.9978790684731287 0.01652493628923288 0.09795400702478035 0.056019192445320505 0.016730654049076307 0.05717615045030661 5.1806667597144356e-08 7.285614342295331 -1.0053530125932382 down TNNIELHYCTGAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNNIELHYCTGAYR 14 0 Q9NVM9;Q9NVM9-2;H0YH12 Q9NVM9 ASUN Protein asunder homolog 0 26320840.0 10642900.0 4556940.0 11121000.0 False True 14577867.743557997 4355599.323014579 8494448.844184479 1.0 0.2987816462348776 0.582694876480698 23.79727638108103 -10.413129761079 6.000008413592183 1.0001684180898112 0.4407382613582824 0.8380214695618952 0.11590709088793005 0.0002612045540998448 2.554881046341754e-05 0.1122597419349516 0.03740885272635843 3.862515532833514e-11 10.413129761079 -0.5594301567315287 TNNIFCSNPNHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNNIFCSNPNHR 12 0 P29590;P29590-4;P29590-2;P29590-5;P29590-9;P29590-3;P29590-8;P29590-11;H3BT57;P29590-14;P29590-10;P29590-12;P29590-13 P29590 PML Protein PML 0 4256110.0 933010.0 1314200.0 2008900.0 False True 1277969.0106471973 1256134.298521762 1534439.1945942077 1.0 0.9829145214449468 1.2006857613997441 20.2854214222541 -6.887936986037631 1.0345312087548881 0.9877136238629213 1.2186747239920637 0.9795438486598775 0.014141966492499427 0.12083204009524726 0.23176397693569858 0.010443091236199936 0.025848228386749526 1.2943836364327908e-07 6.887936986037631 0.2309611001291424 TNNLFK(ub)QVYEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNNLFKQVYEQK 12 1 B1APE1;B1APE2;Q00403 B1APE1 GTF2B Transcription initiation factor IIB 1 7701200.0 2111500.0 2884100.0 2705600.0 True False 2044471.5882766629 4035736.1703828136 1996922.193739837 1.0 1.9739751794666114 0.9767424527640873 20.963296583405292 -6.6516936141448575 2.0040527805687973 1.631215445186947 0.9810605510610435 0.20043451446651606 0.4155409860057917 0.5043166044603755 3.8847953244318947 0.16811527629680142 0.45986525571033043 2.2300078192693314e-07 6.6516936141448575 -0.6501548941259034 TNNLFK(ub)QVYEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNNLFKQVYEQK 12 1 B1APE1;B1APE2;Q00403 B1APE1 GTF2B Transcription initiation factor IIB 1 6328300.0 2111500.0 2234200.0 1982600.0 True False 1755805.8053103362 2222163.921146024 2397152.493493326 1.0 1.2656091661305675 1.3652719943420124 20.743701858839568 -13.16035539157595 0.1452795840373352 5.771287182930888e-09 1.4859557543356388 0.9995920514858576 0.0031137997276350195 8.827455284935722 0.11249135641332993 2.606536455519477 0.10336285327789083 6.912650638299322e-14 13.16035539157595 1.4859557485643515 TNNVSEHEDTDKYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNNVSEHEDTDKYR 14 1 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 5243720.0 496020.0 2620300.0 2127400.0 False True 650287.0234645123 2229361.4538493995 1907277.0554617764 1.0 3.428273013925613 2.9329772648705807 19.31071710939415 -10.104553112209608 5.056086878564255 0.999935267364603 3.180625139403957 0.9627487046740476 0.20220364284609255 70407330.30068086 7.081997956459477 53060.747052328865 0.06921968524473204 7.860440557116482e-11 10.104553112209608 2.1806898720393537 TNNVSEHEDTDKYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TNNVSEHEDTDKYR 14 1 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 12218300.0 2057100.0 9147800.0 1013400.0 False True 3120771.0941544925 7515303.61791237 813101.0458110013 1.0 2.4081559945198365 0.26054491703477345 21.57347111003554 -6.729834085511768 1.7239642371002957 1.8475954611812107 0.26189625335771377 0.5584118179151427 0.5919639713457705 0.33656330030331394 1.9595995603720977 0.2721256126251857 0.6753548189088703 1.8627986498609742e-07 6.729834085511768 -1.5856992078234968 TNNVSEHEDTDKYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNNVSEHEDTDKYR 14 1 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 4722020.0 496020.0 2322200.0 1903800.0 False True 679411.9984364818 2219597.5255115177 1454161.649991765 1.0 3.2669389569501806 2.1403237701692053 19.373927170917042 -9.309354626711396 11.149713942746942 1.0000002686145304 2.703631363559321 0.7530174574626365 0.45993872401398683 0.0 0.0 0.44533375459550245 0.14844458486516746 4.905071849271905e-10 9.309354626711396 1.7036310949447906 TNNVSEHEDTDKYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNNVSEHEDTDKYR 14 1 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 4623500.0 2057100.0 1249200.0 1317200.0 False True 2662956.5015031956 1179680.9218649466 1077483.1156133297 1.0 0.4429966922850733 0.4046191197659849 21.34459743212799 -13.999999999999998 0.37993661584684146 9.260771285195615 0.4012436735481644 0.9998074172381484 0.003775639608021123 24.02713154225058 0.2010107612537661 162.33924546475845 0.010403898087177182 1.0000000000000041e-14 13.999999999999998 -8.85952761164745 TNPFGESGGSTK(ub)SETEDSILHQLFIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNPFGESGGSTKSETEDSILHQLFIVR 27 1 Q9UKG1 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 1 47984100.0 15245000.0 9328100.0 23411000.0 True False 14761055.81969109 13052858.975398887 17278956.78505443 1.0 0.8842767844551142 1.170577294478115 23.8152925815011 -6.796974334005897 1.468134990599186 0.9359032532287109 1.1742448443792706 0.8231965199338335 0.04944619371088697 0.2251053448794275 0.958165547220211 0.026499098267436128 0.061746897623863914 1.595973463505617e-07 6.796974334005897 0.23834159115055964 TNPFGESGGSTK(ub)SETEDSILHQLFIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TNPFGESGGSTKSETEDSILHQLFIVR 27 1 Q9UKG1 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 1 125181000.0 36673000.0 49930000.0 38578000.0 True False 55635622.15542641 41019601.39512941 30953041.390661925 1.0 0.7372902433001475 0.5563529298583196 25.729505566062546 -7.879324594578315 0.1099392629668322 1.453741504639538 1.4003060329736667e-12 0.9999887440062374 0.0006110542732700874 0.12347501752534087 0.016029027226516834 0.09016630496103452 0.11035586907786642 1.3203084580167206e-08 7.879324594578315 -1.453741504638138 TNPFGESGGSTK(ub)SETEDSILHQLFIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNPFGESGGSTKSETEDSILHQLFIVR 27 1 Q9UKG1 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 1 35206400.0 15245000.0 12032000.0 7929400.0 True False 12676892.968011405 11967181.227834992 9587400.878596796 1.0 0.944015324420007 0.7562894869262865 23.595697856935377 -6.948925985675779 0.5705167265337767 1.0023330711558238 0.6888366072238633 0.999114249895398 0.0031019629281267896 0.08391999510848867 0.037770068512362406 0.0032844059895616143 0.01564322669847184 1.1247966502921564e-07 6.948925985675779 -0.3134964639319605 TNPFGESGGSTK(ub)SETEDSILHQLFIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNPFGESGGSTKSETEDSILHQLFIVR 27 1 Q9UKG1 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 1 121900000.0 36673000.0 62705000.0 22522000.0 True False 47473921.43290392 59215411.62787504 18423227.09523489 1.0 1.247325054273548 0.38807047193842825 25.500631888154995 -6.8297308512485015 1.3291152804701645 1.1321769248479836 0.36507498869092814 0.9053409832845606 0.11111783594225418 0.18113843591261894 0.6259125646305281 0.06564392528935571 0.1510665523394201 1.4800253318020124e-07 6.8297308512485015 -0.7671019361570555 down TNPK(ub)IQSIYLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNPKIQSIYLER 12 1 Q9Y5J1 Q9Y5J1 UTP18 U3 small nucleolar RNA-associated protein 18 homolog 1 16018300.0 2790800.0 3740900.0 9486600.0 True False 3612745.6148923803 3532715.6264846157 7760136.140735966 1.0 0.9778478761200715 2.1479885294849725 21.784664242845217 -6.902589082777281 0.9447881671467567 0.9547452695423707 2.2774674429633213 0.9878100487390433 0.06033396186799107 0.1095234817806943 0.16688044504109065 0.04765342172133707 0.1256720556818064 1.2514425499624367e-07 6.902589082777281 1.3227221734209507 up TNQELQEINR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNQELQEINR 10 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YMM1;H0YNA0;H0YN52;H0YLE2 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 24383200.0 3160600.0 12318000.0 8904600.0 False True 4143577.2072939402 10480202.415187933 7983237.410954642 1.0 2.529264423199266 1.9266534715225643 21.9824453734929 -10.209825330142223 6.139248465020574 0.9999826982024846 2.2279589473609183 0.8470120584185467 0.24601489083682856 5.8262407016984866e-05 7.499013365012271e-06 0.23820623717283618 0.0794009645941707 6.168430414448455e-11 10.209825330142223 1.2279762491584336 TNQELQEINR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNQELQEINR 10 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YMM1;H0YNA0;H0YN52;H0YLE2 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 27501000.0 7502600.0 5379400.0 14619000.0 False True 7264434.069715603 7527422.473200407 10789845.339400735 1.0 1.0362021873914673 1.4852974417349414 22.792418979485525 -6.922917803963276 0.8027693687873982 0.9910947451337067 1.5628176832687657 0.994954393237299 0.015679259199335993 0.09648451377642527 0.09693290661897361 0.013722554718805346 0.04232709739657882 1.1942141040613544e-07 6.922917803963276 0.571722938135059 TNQELQEINR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TNQELQEINR 10 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YMM1;H0YNA0;H0YN52;H0YLE2 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 102159000.0 15657000.0 75902000.0 10600000.0 False True 23752813.680023763 62356695.07496725 8504905.353854945 1.0 2.625234042374085 0.3580588585598856 24.501595084677557 -6.714302945373392 1.7798794072965984 1.9947537290467334 0.36269724270130194 0.48545499840908524 0.6844262823404563 0.3665196692753597 2.265960114268691 0.30571063333840354 0.7726195718924924 1.9306211279516962e-07 6.714302945373392 -1.6320564863454314 TNQELQEINR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNQELQEINR 10 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YMM1;H0YNA0;H0YN52;H0YLE2 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 25180600.0 3160600.0 10871000.0 11149000.0 False True 4329159.232003442 10390683.274410335 8515835.82086257 1.0 2.4001619523710036 1.9670876871215532 22.045655435015792 -10.15159078116031 4.917307187288085 0.999920324408555 2.1836248197499546 0.9087558344680852 0.17680182844469142 61848995.07684776 8.367119238009876 55795.80758952684 0.06052396852764806 7.053573868352973e-11 10.15159078116031 1.1837044953413995 TNQELQEINR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNQELQEINR 10 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YMM1;H0YNA0;H0YN52;H0YLE2 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 15669000.0 7502600.0 5637000.0 2529400.0 False True 6238744.321535085 5606632.362143102 3058285.8453757786 1.0 0.8986796177541625 0.49020855604213426 22.5728242549198 -6.94469458405049 0.6143381945511011 1.0044933394727202 0.36296398471402724 0.9987163836792181 0.00789473996312128 0.08568870305658244 0.04533664859743744 0.007992203112864174 0.0344967290210603 1.1358092884581622e-07 6.94469458405049 -0.641529354758693 down TNQELQEINR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNQELQEINR 10 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YN28;H0YL33;H0YMM1;H0YNA0;H0YN52;H0YLE2 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 40094000.0 15657000.0 12451000.0 11986000.0 False True 20268295.145610582 11758090.904691357 9804670.986745639 1.0 0.5801223447862489 0.48374423780132264 24.272721406770007 -13.999999999999998 0.20677111979905882 3.39665572561069 0.42516837619063186 0.999488454106577 0.00506921718959573 12.673030998280874 0.1441489123275254 12.320458511253548 0.05840899786670627 1.0000000000000041e-14 13.999999999999998 -2.9714873494200584 TNRPPLSLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNRPPLSLSR 10 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 44567000.0 10848000.0 21090000.0 12629000.0 False True 14221833.052181436 17943454.2081761 11322272.225922143 1.0 1.2616836481162192 0.7961190505035116 23.761604090129303 -6.75418803331535 1.6343444232345152 1.153092704272276 0.7948889625262197 0.6668149558214385 0.10999171454092797 0.2927846971903435 1.5398805164982854 0.05313707720916985 0.1284404485883428 1.761213341612822e-07 6.75418803331535 -0.3582037417460564 TNRPPLSLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNRPPLSLSR 10 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 40220800.0 13116000.0 9508800.0 17596000.0 False True 12699639.759335427 13305713.427736927 12987079.731315091 1.0 1.0477236897964746 1.0226337106742236 23.598284237997053 -9.888302122603317 8.234121306961013 1.0000000134175613 1.035178700872852 0.7238472596768984 0.010242941084435927 0.0 0.0 0.00991768505904968 0.0033058950196832265 1.2932958303734e-10 9.888302122603317 0.035178687455290625 TNRPPLSLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TNRPPLSLSR 10 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 106814000.0 29074000.0 61447000.0 16293000.0 False True 44107383.59411203 50481302.76239776 13072681.4085244 1.0 1.1445091195374506 0.29638306204745035 25.394516847952655 -6.863022924964653 1.1702879163085624 1.0791338320453152 0.252861313925498 0.9572146192493778 0.07663174383746187 0.1437246576710011 0.37232255997149555 0.051003579572523064 0.11949905141614142 1.3708094037750864e-07 6.863022924964653 -0.8262725181198172 down TNRPPLSLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNRPPLSLSR 10 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 37655000.0 10848000.0 13691000.0 13116000.0 False True 14858798.756177094 13086086.349917373 10018270.9324992 1.0 0.8806961157931579 0.6742315510757159 23.824814151652195 -6.96277268350455 0.39441687261061725 1.0120726674749143 0.5353837501257666 0.9998596124644116 0.0015944667915526998 0.07872515206555124 0.01757759928195068 0.0026602309919754514 0.017335773099666156 1.0895002054928554e-07 6.96277268350455 -0.47668891734914776 TNRPPLSLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNRPPLSLSR 10 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 34626500.0 13116000.0 15355000.0 6155500.0 False True 10906535.137319632 15272279.567271128 7442586.590183681 1.0 1.4002870182862137 0.6823969754351111 23.37868951343133 -6.755391997737437 1.629898564293178 1.2338420550759484 0.6803644877633378 0.6718092025583429 0.16826879460319713 0.29074661695442827 1.521180772434992 0.0815010371271011 0.19675488734589378 1.7563376136595116e-07 6.755391997737437 -0.5534775673126106 TNRPPLSLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNRPPLSLSR 10 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7;F8VUA6 J3QQ67 RPL18 60S ribosomal protein L18 0 72620000.0 29074000.0 23425000.0 20121000.0 False True 37636866.13422003 22121378.157770045 16459184.458894467 1.0 0.5877582389267246 0.4373154874318699 25.165643170045104 -13.999999999954586 0.1401810642848776 2.969525082693038 0.2515402059291359 0.999602212525237 0.0047439922797377475 11.934190478944895 0.11731861499744542 6.428827963028739 0.16610103541629873 1.0000000001045705e-14 13.999999999954586 -2.7179848767639023 TNSSNLQYK(ub)EALEATLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNSSNLQYKEALEATLDR 18 1 Q8N6F8 Q8N6F8 WBSCR27 Williams-Beuren syndrome chromosomal region 27 protein 1 95809300.0 3696300.0 10014000.0 82099000.0 True False 3578962.979752324 14012642.422320137 60594808.98279371 1.0 3.9152800690019594 16.93082865779938 21.771110190137996 -6.942359930944678 0.6372333722312531 0.8577498013233036 20.698571533505365 0.9984569224043714 0.27205766645828977 0.08670640806408997 0.0498299270810916 0.2698271434415063 1.1090995723118273 1.1419315420436335e-07 6.942359930944678 19.84082173218206 TNSSNLQYK(ub)EALEATLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNSSNLQYKEALEATLDR 18 1 Q8N6F8 Q8N6F8 WBSCR27 Williams-Beuren syndrome chromosomal region 27 protein 1 65412100.0 3696300.0 7924800.0 53791000.0 True False 3073637.2238544156 7882107.5294503635 65038449.39851691 1.0 2.564423500690823 21.160092965349083 21.551515465572272 -6.923530639840367 0.7980991606474948 0.6395272370885502 24.41670797589239 0.995106892058739 0.6405474760608956 0.09613867794250322 0.09517252993034796 0.5624803166097873 1.7462434335545154 1.1925301288859522e-07 6.923530639840367 23.77718073880384 TNSTFNQVVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNSTFNQVVLK 11 0 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7 J3QQ67 RPL18 60S ribosomal protein L18 0 86739000.0 16453000.0 32868000.0 37418000.0 False True 21570042.331078667 27964222.518460527 33546344.298800725 1.0 1.2964379990190822 1.5552284869866155 24.362525671993044 -6.972717601538897 0.18191400335079955 0.8049450167270646 2.0537330502847158 0.9999965541565687 0.00042105185979592297 0.0754303707080473 0.005749385324095736 0.009798916026546237 0.028874970062689565 1.0648351985028985e-07 6.972717601538897 1.2487880335576511 TNSTFNQVVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNSTFNQVVLK 11 0 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7 J3QQ67 RPL18 60S ribosomal protein L18 0 85803000.0 16453000.0 31171000.0 38179000.0 False True 22536118.725606743 29793762.15128734 29161906.521186836 1.0 1.3220449587636434 1.2940074942031397 24.425735733515936 -10.081159051338316 4.444277557627234 0.9999745998691496 1.3080262264988256 0.9938244853538547 0.01144624704661154 7952714.000314263 0.09498456174510848 2067.933443395406 0.0039183548058524965 8.295469075426009e-11 10.081159051338316 0.308051626629676 TNSTFNQVVLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNSTFNQVVLKR 12 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7 J3QQ67 RPL18 60S ribosomal protein L18 1 40575100.0 3541900.0 8051600.0 28981600.0 True False 4643465.199808388 6850332.6648909915 25982862.043137614 1.0 1.4752630568166354 5.595575916927253 22.1467703920846 -6.92863208982835 0.7579359556487788 0.9340581074930397 6.412724713901697 0.9962624782231301 0.1261524424058972 0.09335451115278064 0.08120567502049127 0.11400906225237688 0.3756612184423811 1.1786039985931511e-07 6.92863208982835 5.478666606408657 up TNSTFNQVVLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNSTFNQVVLKR 12 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7 J3QQ67 RPL18 60S ribosomal protein L18 1 54974300.0 4266200.0 5188000.0 45520100.0 True False 4130771.8161998102 7259595.455062601 33597020.2362717 1.0 1.7574428649368528 8.133351763588816 21.97797993725743 -6.92916109491097 0.7536435513509339 0.8999634141255212 9.414773476311732 0.9963708254354502 0.19272478836457207 0.09307580426505802 0.07983062959514829 0.1747132644017841 0.5795941740006357 1.1771692395594474e-07 6.92916109491097 8.51481006218621 up TNSTFNQVVLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 TNSTFNQVVLKR 12 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7 J3QQ67 RPL18 60S ribosomal protein L18 1 71337900.0 7100000.0 13635000.0 50602900.0 True False 10771219.079527933 11201727.719258754 40601214.63496101 1.0 1.0399684229382222 3.769416844573217 23.36067820661529 -6.910088548067846 0.8951439562693068 0.9157272524032563 4.122806281123916 0.9909546356632872 0.1232776285411925 0.10435923066691286 0.13845456366438308 0.10097322214962887 0.27889863610244214 1.2300179575457308e-07 6.910088548067846 3.20707902872066 up TNSTFNQVVLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNSTFNQVVLKR 12 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7 J3QQ67 RPL18 60S ribosomal protein L18 1 60103900.0 3541900.0 4354400.0 52207600.0 True False 4851436.14624849 4162008.2099247896 39877240.12927306 1.0 0.8578919900127265 8.219677416574731 22.209980453607493 -6.902501547737781 0.945339896758552 0.7145764608096207 9.03284669232127 0.9877696889127648 0.38014165427106855 0.10958658168038968 0.16722609261413804 0.3001216183713007 0.7911168381075854 1.251694812236379e-07 6.902501547737781 8.318270231511649 up TNSTFNQVVLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNSTFNQVVLKR 12 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7 J3QQ67 RPL18 60S ribosomal protein L18 1 64670200.0 4266200.0 8035000.0 52369000.0 True False 3547534.324705165 7991713.860177382 63319115.773102 1.0 2.252751666001589 17.84876761646681 21.758385212691707 -6.922872157263938 0.803154293748772 0.690169351091759 20.537620476911727 0.9949417746853556 0.5451007312404319 0.09651179147872291 0.09707820491923075 0.47694520029597165 1.470341309365025 1.194339629020283e-07 6.922872157263938 19.84745112581997 up TNSTFNQVVLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNSTFNQVVLKR 12 1 J3QQ67;Q07020;G3V203;F8VYV2;Q07020-2;A0A075B7A0;H0YHA7 J3QQ67 RPL18 60S ribosomal protein L18 1 107098900.0 7100000.0 8877900.0 91121000.0 True False 9191089.961923435 8383837.060698684 74537912.98041466 1.0 0.912170057678794 8.109801262876115 23.13180452870774 -6.9041378854281765 0.9347306266482113 0.7337662980786267 8.93217013494496 0.9885150731289892 0.361421610677253 0.10842344675156097 0.16073720130239524 0.2875792493791174 0.7650330219464944 1.2469875416569254e-07 6.9041378854281765 8.198403836866333 up TNTPVK(ub)EDWNVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNTPVKEDWNVR 12 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 11240900.0 2960300.0 2958300.0 5322300.0 True False 2866326.8968862914 4139564.6173306964 3928229.964422508 1.0 1.4442053423241887 1.370475212959753 21.450771723803033 -10.679263524598804 6.548963278680845 0.9967680401796837 1.40734027764197 0.9760175154939894 0.030100199268710336 0.001428271027797862 6.994973662551843e-05 0.029305957973160438 0.009714797540436658 2.092842159373145e-11 10.679263524598804 0.4105722374622862 TNTPVK(ub)EDWNVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TNTPVKEDWNVR 12 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 31557100.0 5532800.0 5356300.0 20668000.0 True False 8393662.101860859 4400426.416037087 16582960.740893802 1.0 0.5242558447833541 1.9756526459669363 23.0008689560908 -6.818420562467334 1.378808910197791 0.7431593166717155 2.006246339608897 0.8806779881189511 0.20868555480707598 0.19554925286502697 0.7309330179590977 0.11895196739556692 0.2742720386519276 1.5190757733212743e-07 6.818420562467334 1.2630870229371816 TNTPVK(ub)EDWNVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNTPVKEDWNVR 12 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 6410400.0 2196800.0 1981300.0 2232300.0 True False 3009016.3262877837 1893759.6147170658 1705076.7156616321 1.0 0.6293616947746483 0.5666558538634389 21.52086050377559 -13.999999999999998 0.24998558114770378 3.577429502302743 0.541439365616517 0.9995426611522282 0.004089365908807389 13.997464564400742 0.15821311705830698 18.116393759428654 0.028940773915729284 1.0000000000000041e-14 13.999999999999998 -3.035990136686226 TNTPVK(ub)EDWNVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNTPVKEDWNVR 12 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347;A0A494C0Q7 A0A494C1K3 GTF2I General transcription factor II-I 1 9151100.0 2960300.0 3627200.0 2563600.0 True False 2461620.6135260183 3607659.553657173 3099636.9072528505 1.0 1.4655627816219705 1.25918546920719 21.23117699923731 -10.091862838270332 4.373304911555901 0.9999634731704282 1.362374125447648 0.8043369455074594 0.08425318509825426 29300123.853454273 1.0176192071683903 11415.33786226707 0.028842106245434096 8.093514735045809e-11 10.091862838270332 0.3624106522772198 TNTVK(ub)VPKPIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNTVKVPKPIK 11 2 Q9HA64;I3L3W5;I3L2G3;I3L139 Q9HA64 FN3KRP Ketosamine-3-kinase 1 6789600.0 2090800.0 2836600.0 1862200.0 True False 2741059.047336001 2413390.336980199 1669517.4074837444 1.0 0.8804590836252656 0.6090775056839167 21.38630197606549 -6.957493632001528 0.46943140479750756 1.0072076874454863 0.47121435527994004 0.9996656266832379 0.0029907799218087065 0.08060899507054488 0.024534433604455234 0.0037482945456409748 0.022399513236830787 1.1028244042890286e-07 6.957493632001528 -0.5359933321655462 TNTVK(ub)VPKPIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNTVKVPKPIK 11 2 Q9HA64;I3L3W5;I3L2G3;I3L139 Q9HA64 FN3KRP Ketosamine-3-kinase 1 7593100.0 2090800.0 3712900.0 1789400.0 True False 2863825.2617454883 3548851.8010816053 1366780.5738498052 1.0 1.2391998382326568 0.47725697238132425 21.44951203758838 -6.822297666381218 1.361684492437555 1.128636867702834 0.4597564981754242 0.8896475307680376 0.10569075719296905 0.19049918250761536 0.6933896329372025 0.060981297735438804 0.1404886408372235 1.505574788234298e-07 6.822297666381218 -0.6688803695274098 down TNTVK(ub)VPKPIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNTVKVPKPIK 11 2 Q9HA64;I3L3W5;I3L2G3;I3L139 Q9HA64 FN3KRP Ketosamine-3-kinase 1 11589910.0 2839900.0 7893400.0 856610.0 True False 2361502.678901649 7850876.68748277 1035723.1904828616 1.0 3.3245258443383454 0.4385864982226416 21.171273741414783 -6.692341402372658 1.8579320510166026 2.4541690796185396 0.4482590844090938 0.3813332824402389 0.9826589174891529 0.4117402935319503 2.7573780534924843 0.4228093107827967 1.097852989497799 2.030759986601683e-07 6.692341402372658 -2.005909995209446 TNTVSYK(ub)AGLICR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNTVSYKAGLICR 13 1 A0A0U1RR27;Q7Z401;Q7Z401-2;H3BTW5 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 6044500.0 1636100.0 2090700.0 2317700.0 True False 2241010.3839400224 1998325.9609796403 1770306.994529839 1.0 0.8917075865870342 0.7899593001516493 21.095717903056045 -6.97187884175079 0.20850759663598628 1.0542959687798044 0.6245353233811468 0.9999935572203755 0.00021761154144793256 0.07569781390877739 0.0068045225717328055 0.0030833081943738446 0.010580289442808888 1.0668937187163064e-07 6.97187884175079 -0.42976064539865755 TNTVSYK(ub)AGLICR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNTVSYKAGLICR 13 1 A0A0U1RR27;Q7Z401;Q7Z401-2;H3BTW5 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 17081800.0 3374400.0 4429600.0 9277800.0 True False 4368227.319368231 4183088.8660686626 7589335.598267033 1.0 0.957617028656296 1.7373948385462377 22.058616504334662 -6.894055555959339 0.9981112699579837 0.9620832112618415 1.8100365772591267 0.9833686407543535 0.04617111969934272 0.11591338231213506 0.2031336780038024 0.03504616324946881 0.08874517115727086 1.2762755342361857e-07 6.894055555959339 0.8479533659972852 TNVALMCMLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNVALMCMLR 10 0 O75643;A0A494C1A5;O75643-2 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 9145500.0 2479500.0 3574500.0 3091500.0 False True 3250648.5115121524 3041198.533291869 2771621.2357620005 1.0 0.9355667100030909 0.8526363973054363 21.632296137006428 -6.9676763039041365 0.308686431199723 1.012975910913893 0.7725960863014454 0.9999581555492725 0.00039014263038464813 0.07706413969449388 0.011715226745146712 0.0013199871208443258 0.00737206311609618 1.0772678429271383e-07 6.9676763039041365 -0.24037982461244756 TNVALMCMLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNVALMCMLR 10 0 O75643;A0A494C1A5;O75643-2 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 2479500.0 2479500.0 0.0 0.0 False True 3396238.155968018 0.0 0.0 1.0 0.0 0.0 21.69550619852932 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 TNVFNATFHIWHSGQFGTINNFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TNVFNATFHIWHSGQFGTINNFR 23 0 Q14457;K7ELY9;E7EV84;K7ERY0 Q14457 BECN1 Beclin-1 0 34819000.0 8497000.0 10152000.0 16170000.0 False True 12890570.213908285 8340296.282061974 12973992.41243724 1.0 0.6470075523162822 1.0064715677541516 23.619812746885703 -10.911067930522035 10.7949273633331 1.0189969632508238 0.8267395600352169 0.2365019189331956 0.14675056978578585 0.06090945559885039 0.0005017908782078095 0.12899248773180352 0.04736354273556648 1.2272472552744562e-11 10.911067930522035 -0.19225740321560691 TNVFNATFHIWHSGQFGTINNFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNVFNATFHIWHSGQFGTINNFR 23 0 Q14457;K7ELY9;E7EV84;K7ERY0 Q14457 BECN1 Beclin-1 0 30637000.0 8497000.0 10941000.0 11199000.0 False True 10999534.00091034 10332123.732088044 9160896.911443727 1.0 0.9393237687371975 0.8328440923665998 23.390939068978152 -6.9625193614692735 0.39834805815200686 1.0059610476850938 0.7623292453013036 0.9998525065940636 0.000839054282164484 0.07881324465763408 0.01789449298599931 0.0013704410046987935 0.008926802386585282 1.0901358914842749e-07 6.9625193614692735 -0.24363180238379012 TNVNGGAIALGHPLGGSGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNVNGGAIALGHPLGGSGSR 20 0 P42765;A0A0B4J2A4;K7EME0 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 75147000.0 15342000.0 25217000.0 34588000.0 False True 20113510.572139323 21454721.895096138 31009165.55152383 1.0 1.0666821099253865 1.5417082681964465 24.261661572955763 -6.932319927091378 0.7274928908661051 0.9933618746383068 1.6452532148024475 0.9969749857759154 0.013265361581057648 0.09145074145018506 0.07190794286788584 0.012256724240044628 0.04244657172318859 1.1686381856034175e-07 6.932319927091378 0.6518913401641406 TNVNGGAIALGHPLGGSGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNVNGGAIALGHPLGGSGSR 20 0 P42765;A0A0B4J2A4;K7EME0 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 44910500.0 14258000.0 9406500.0 21246000.0 False True 13805387.59443461 13162564.504249487 15681035.233662257 1.0 0.953436795179567 1.1358634537710321 23.718728057224006 -6.839000874865907 1.2869116340613302 0.9752239922053356 1.141749989746336 0.9227356022261373 0.02151240640327702 0.16997384302907992 0.5472314967333646 0.013109373115221574 0.03019579270471218 1.44876893506461e-07 6.839000874865907 0.16652599754100028 TNVNGGAIALGHPLGGSGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TNVNGGAIALGHPLGGSGSR 20 0 P42765;A0A0B4J2A4;K7EME0 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 99933000.0 18686000.0 60435000.0 20812000.0 False True 28348028.12958579 49649902.069189854 16698499.077776331 1.0 1.7514411176053577 0.5890532844627991 24.75674504993964 -6.732153064027102 1.7151583062043225 1.4511146855996857 0.5894368780691106 0.5693451097977396 0.31583758235040227 0.3322013736321108 1.915457666523321 0.14586331110347414 0.3611015824243141 1.8528784743725986e-07 6.732153064027102 -0.8616778075305751 TNVNGGAIALGHPLGGSGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNVNGGAIALGHPLGGSGSR 20 0 P42765;A0A0B4J2A4;K7EME0 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 60772000.0 15342000.0 15841000.0 29589000.0 False True 21014352.001960613 15141092.240818148 22600687.604583625 1.0 0.7205119738836345 1.075488199801498 24.324871634478654 -6.696766068470518 1.8422737185896563 0.8259017470950448 1.07437441739735 0.4022721197253404 0.11804676615549242 0.40230504445289245 2.6522040088030203 0.05116200578902612 0.13210925814747093 2.0101752964446888e-07 6.696766068470518 0.24847267030230513 TNVNGGAIALGHPLGGSGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNVNGGAIALGHPLGGSGSR 20 0 P42765;A0A0B4J2A4;K7EME0 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 32460300.0 14258000.0 11248000.0 6954300.0 False True 11856158.73649765 11187404.791446814 8408411.976949781 1.0 0.9435943833147102 0.7092020412197733 23.499133332658282 -6.943999548361818 0.6212439190382256 1.0025632889502616 0.6377889744695315 0.9986421992293514 0.004639651018398091 0.08598853582824291 0.04665044248306223 0.004667191752222094 0.019846033068846684 1.1376284688828703e-07 6.943999548361818 -0.36477431448073006 TNVNGGAIALGHPLGGSGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNVNGGAIALGHPLGGSGSR 20 0 P42765;A0A0B4J2A4;K7EME0 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 54141000.0 18686000.0 15643000.0 19812000.0 False True 24189395.356126968 14772453.298697866 16206419.288286725 1.0 0.6106995681872689 0.669980338478439 24.527871372032088 -10.475893327787729 6.113314260822602 1.0002248347329739 0.6403399533328832 0.9800315376603144 0.02420127312875123 7.420740144172549e-05 6.361919058328059e-06 0.023447194587660532 0.007810927315389204 3.3427713571054094e-11 10.475893327787729 -0.3598848814000907 TNVPTFSQSNLEQQK(ub)QLYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNVPTFSQSNLEQQKQLYLR 20 1 Q96BU1-2;Q96BU1 Q96BU1-2 S100PBP S100P-binding protein 1 12195100.0 2998600.0 3812700.0 5383800.0 True False 2493468.7605037093 3792160.2283383077 6509527.688121338 1.0 1.5208372723194847 2.6106313386522393 21.249722697593413 -6.9591519471846945 0.4472246018426578 0.963842226276283 3.210629686539494 0.9997374438192868 0.01087379404413235 0.08000544906694225 0.022261154468349326 0.014507456628611174 0.09018250393067585 1.0986213960629301e-07 6.9591519471846945 2.246787460263211 TNVPVK(ub)LFAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNVPVKLFAR 10 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 10379400.0 2732500.0 3735300.0 3911600.0 True False 2645758.2831948763 5226824.769332176 2887034.6145153553 1.0 1.9755488634511773 1.091193641102061 21.335249832163257 -6.622791682707873 2.1071502316241872 1.6460600354524841 1.0946662089269645 0.09202861563502407 0.41922856918565393 0.5779699639483314 4.88052946605701 0.16328553385917205 0.4645458132515582 2.3834624665761274e-07 6.622791682707873 -0.5513938265255196 TNVPVK(ub)LFAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNVPVKLFAR 10 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 4248980.0 1409100.0 2002100.0 837780.0 True False 1930082.34949568 1913640.6019406617 639913.6186207061 1.0 0.9914813232920789 0.33154731392052367 20.880230972607432 -6.9097154948697375 0.8976711323560624 1.020617524776812 0.24677928611658162 0.9908136327398066 0.03001144779841408 0.10460673738636443 0.13979077303647333 0.024536197551346547 0.06759815020930407 1.2310749805718243e-07 6.9097154948697375 -0.7738382386602303 down TNVPVK(ub)LFAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNVPVKLFAR 10 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 1 7466820.0 2732500.0 3745500.0 988820.0 True False 2272194.8202749197 3725322.2480764636 1195577.6902128893 1.0 1.6395258957705596 0.526177456063487 21.115655107597533 -6.750944752406432 1.6465854994250728 1.3756184080885474 0.5238339479960173 0.652965620316271 0.2687442670619661 0.2983822381055239 1.5920082058538185 0.12892268071114452 0.3126504444777752 1.7744151939451482e-07 6.750944752406432 -0.8517844600925301 TNYNDRYDEIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNYNDRYDEIR 11 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 16433400.0 2656300.0 7646900.0 6130200.0 False True 3482435.02364579 6506012.3273827415 5495905.709030629 1.0 1.8682365308201914 1.5781789672207351 21.731665004149693 -10.33893893636879 5.719656497115906 0.9998802650703752 1.7232077490204667 0.8923445351836156 0.11841550447560355 0.00018083069813675702 2.0899728008032816e-05 0.11467401153415256 0.03821843973056174 4.582063079200255e-11 10.33893893636879 0.7233274839500915 TNYNDRYDEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNYNDRYDEIR 11 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 20678300.0 7142500.0 5573100.0 7962700.0 False True 6915765.247106835 7798467.893332565 5877029.994120412 1.0 1.1276362939871336 0.8498018345227997 22.721457467427726 -6.781753412541845 1.5287148476367616 1.0721035791175102 0.8474651665769053 0.773685742725829 0.054018589201659147 0.24783969949441675 1.1440694474581727 0.027826523921839343 0.06557226354525328 1.6529000296477333e-07 6.781753412541845 -0.2246384125406049 TNYNDRYDEIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TNYNDRYDEIR 11 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 63378000.0 14362000.0 40389000.0 8627000.0 False True 21788204.002842303 33181267.389302634 6921869.668651579 1.0 1.5229005284223558 0.3176888589692207 24.377043944512035 -6.788789334148341 1.5011573605332993 1.2927117443874006 0.3052940415364628 0.7973729116421973 0.2221258430484613 0.23716588397306287 1.0558383769259587 0.11647724929615523 0.2729452908313663 1.6263374617951487e-07 6.788789334148341 -0.9874177028509378 down TNYNDRYDEIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TNYNDRYDEIR 11 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 13463700.0 2656300.0 5225600.0 5581800.0 False True 3638405.8938083695 4994715.71325165 4263493.800779506 1.0 1.3727758416814824 1.1718026864553168 21.794875065672585 -10.157112144914644 4.180304710372726 0.9999295429851914 1.27228926404645 0.7099351920229964 0.08204694740751958 11598628.538457053 14090914.732772784 6875.221018910812 0.028086853873122875 6.964466522002795e-11 10.157112144914644 0.2723597210612586 TNYNDRYDEIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TNYNDRYDEIR 11 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 14637500.0 7142500.0 4723000.0 2772000.0 False True 5939305.216400233 4697556.261557897 3351612.3837201144 1.0 0.790926899763715 0.5643105147156422 22.501862742862002 -6.970095163781813 0.25590074346142705 1.0668930111293777 0.2816567031019057 0.9999831152153225 0.0007310599585905004 0.07627183846383698 0.008919487146686075 0.004858916881515656 0.02151580524006336 1.0712845367510522e-07 6.970095163781813 -0.785236308027472 TNYNDRYDEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TNYNDRYDEIR 11 1 P62424;Q5T8U2 P62424 RPL7A 60S ribosomal protein L7a 0 32963500.0 14362000.0 8957900.0 9643600.0 False True 18591892.1173443 8459384.990373036 7888563.751691993 1.0 0.455003984370225 0.42430128692134483 24.148170266604485 -13.90825084755588 0.41022013043084304 9.999999999999906 0.42290125529138256 0.9998503715537056 0.003234788248853608 26.165383835318334 0.21213005536073418 209.7997802943885 0.007644558546317614 1.235233759001409e-14 13.90825084755588 -9.577098744708524 TNYVVWGTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TNYVVWGTGK 10 0 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2;A0A2R8Y640;A0A3B3ISN2 A0A3B3IRP5 CDC73 Parafibromin 0 9042000.0 2615700.0 2821000.0 3605300.0 False True 3429208.0304748323 2400117.7961718743 3232258.1404796117 1.0 0.6999044020783822 0.9425669459989134 21.709443996324694 -9.944148874206519 6.139225510622189 1.000000058907742 0.8212356747819627 0.4198169622801027 0.09906656871525361 7.984534492676503e-08 1.3736357443724692e-08 0.0959208241452121 0.03197359756666175 1.1372373791095241e-10 9.944148874206519 -0.17876438412577933 TNYVVWGTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TNYVVWGTGK 10 0 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3;A0A1B0GUB2;A0A2R8Y640;A0A3B3ISN2 A0A3B3IRP5 CDC73 Parafibromin 0 3495600.0 2452400.0 1043200.0 0.0 False True 2374549.904375893 1459755.2002161327 0.0 1.0 0.614750272262567 0.0 21.179222646025398 -7.615794051897965 0.6728726625141455 0.9970193691110817 3.427112675383763e-21 0.9871650008124713 0.04665536934336811 0.12119844043594842 0.14728027700202725 0.0423927621336765 0.07728471297868217 2.4221774025164807e-08 7.615794051897965 -0.9970193691110817 down TPAALAALSLTGSGTPPTAANYPSSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPAALAALSLTGSGTPPTAANYPSSSR 27 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 5885700.0 1424000.0 2807700.0 1654000.0 False True 1866877.790035617 2388802.1043288815 1482859.9462883202 1.0 1.2795706912787832 0.7942994202421947 20.832196057959358 -6.750459111407971 1.648081301136441 1.164292333298543 0.7932948010293985 0.6510481762450397 0.1174796140698135 0.2992055454809392 1.599103864241439 0.056306706488991554 0.13663507316158963 1.776400507568506e-07 6.750459111407971 -0.37099753226914456 TPAALAALSLTGSGTPPTAANYPSSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPAALAALSLTGSGTPPTAANYPSSSR 27 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 8331700.0 1424000.0 2532900.0 4374800.0 False True 1950491.2821530413 2420988.102819792 3341562.3418342085 1.0 1.241219648081377 1.7131900933931064 20.89540611948225 -6.960472209477471 0.42873492889141757 0.9809991026814001 1.9914719378592711 0.9997872936890707 0.004319838148255964 0.07953297721652046 0.02051194493165182 0.006147069544856535 0.03919975385111378 1.0952866405634539e-07 6.960472209477471 1.010472835177871 TPAEVVSTCDITFACVSDPK(ub)AAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPAEVVSTCDITFACVSDPKAAK 23 1 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2;K7EK70 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 1 17096800.0 4131600.0 7065700.0 5899500.0 True False 5416567.610471312 6011525.101882879 5289076.331999965 1.0 1.1098403147892761 0.9764627181566273 22.36894749839667 -6.687926672170614 1.87381688818599 1.0689960715377338 0.9769351594356355 0.36074296227917635 0.04647440849865683 0.42112928174527664 2.865233022885352 0.01985351264360022 0.05183480176313556 2.0515085336030813e-07 6.687926672170614 -0.09206091210209832 TPAEVVSTCDITFACVSDPK(ub)AAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPAEVVSTCDITFACVSDPKAAK 23 1 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2;K7EK70 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 1 45882000.0 15721000.0 16430000.0 13731000.0 True False 23849906.359050516 13497938.131824085 11017061.831488905 1.0 0.5659535064254839 0.46193312735201464 24.507480266056636 -13.999999999999998 0.20066891997923145 3.4189659612292767 0.394821055092865 0.9994869701321009 0.005278195182461648 12.54417353406049 0.14203804270764817 11.913169928928735 0.06590576298214015 1.0000000000000041e-14 13.999999999999998 -3.024144906136412 TPAEVVSTCDITFACVSDPK(ub)AAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPAEVVSTCDITFACVSDPKAAK 23 1 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2;K7EK70 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 1 16714500.0 4131600.0 5318700.0 7264200.0 True False 5659164.172291783 5083702.247411111 5548545.570895135 1.0 0.8983132654644957 0.98045319096091 22.43215755991956 -10.170015784077691 4.5409283495400015 1.0000103203323316 0.9393832282116864 0.42067011168945345 0.03353348416620522 3.504225225303445e-06 6.405101059218603e-07 0.032474184140500996 0.010822885475847768 6.760584041557919e-11 10.170015784077691 -0.06062709212064521 TPAEVVSTCDITFACVSDPK(ub)AAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPAEVVSTCDITFACVSDPKAAK 23 1 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2;K7EK70 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 1 37985900.0 15721000.0 14509000.0 7755900.0 True False 20351144.407239206 13701561.39556397 6344405.782254344 1.0 0.6732575388089782 0.311746880435753 24.278606588149085 -7.243878734346054 0.30353862169143087 1.0719786901143957 4.962578618278194e-12 0.9998924430509084 0.002915248530615634 0.09629341930259554 0.018459741306008415 0.011168900891653146 0.04402894708362229 5.703234983360923e-08 7.243878734346054 -1.0719786901094333 down TPAILYTYSGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPAILYTYSGLR 12 0 Q8N684-2;Q8N684;Q8N684-3;F5H669;J3QT54;F5H6M0;F5H047;C9J286;C9J323;F5H5B7;F5H1W4;F5H2K8;F5H6P5;F5H6A8;F5GXA3;C9JM38 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 0 15733200.0 5849400.0 5043300.0 4840500.0 False True 7668620.045670181 4290859.2986294255 4339651.493354667 1.0 0.5595347367682025 0.565897314968017 22.870535560040288 -9.941992749553224 6.943828016516849 1.0000000196853513 0.5627160258683854 0.9998412427382145 0.0025975116730227394 7.934908970101079e-10 1.2143583295915464e-10 0.002515029956488412 0.000838343287598834 1.142897415040738e-10 9.941992749553224 -0.4372839938169659 TPAILYTYSGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPAILYTYSGLR 12 0 Q8N684-2;Q8N684;Q8N684-3;F5H669;J3QT54;F5H6M0;F5H047;C9J286;C9J323;F5H5B7;F5H1W4;F5H2K8;F5H6P5;F5H6A8;F5GXA3;C9JM38 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 0 7847700.0 3267500.0 1440000.0 3140200.0 False True 3163775.0010390747 2014999.5095007976 2317687.416019307 1.0 0.6368972220967084 0.7325702413281955 21.593215572286788 -10.00429751161549 6.909374948513014 1.0000000415906471 0.6847337317124528 0.9353930333977508 0.03905834654477271 2.4981973036528805e-08 3.6702315241633318e-09 0.037818085932825006 0.012606027141524956 9.90153412059264e-11 10.00429751161549 -0.3152663098781944 TPAILYTYSGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPAILYTYSGLR 12 0 Q8N684-2;Q8N684;Q8N684-3;F5H669;J3QT54;F5H6M0;F5H047;C9J286;C9J323;F5H5B7;F5H1W4;F5H2K8;F5H6P5;F5H6A8;F5GXA3;C9JM38 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 0 13427700.0 5849400.0 3397000.0 4181300.0 False True 8012081.254091291 3246909.3076232118 3193763.056576616 1.0 0.4052516699035234 0.3986184057913482 22.93374562156318 TPAILYTYSGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPAILYTYSGLR 12 0 Q8N684-2;Q8N684;Q8N684-3;F5H669;J3QT54;F5H6M0;F5H047;C9J286;C9J323;F5H5B7;F5H1W4;F5H2K8;F5H6P5;F5H6A8;F5GXA3;C9JM38 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 0 7503800.0 3267500.0 1951600.0 2284700.0 False True 2717071.024793527 1941086.3434377324 2762420.2067407495 1.0 0.7144039760923208 1.016690466142919 21.373620847721064 -11.049821560352015 11.991231294871415 1.5320980120071288 0.8655472211176198 0.20872264224471315 0.12340794279347829 0.04153004008664066 0.00017255060993336506 0.002826778870218543 0.039829742269071586 8.916172038502582e-12 11.049821560352015 -0.666550790889509 TPAILYTYSGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPAILYTYSGLR 12 0 Q8N684-2;Q8N684;Q8N684-3;F5H669;J3QT54;F5H6M0;F5H047;C9J286;C9J323;F5H5B7;F5H1W4;F5H2K8;F5H6P5;F5H6A8;F5GXA3;C9JM38 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 0 16663700.0 5218600.0 5594300.0 5850800.0 False True 6755580.573985024 5282972.287215078 4786014.434277608 1.0 0.7820160279871735 0.7084534603447715 22.687648329284723 -13.999999999999911 0.15169774592231586 2.056894424734319 0.6290787432687632 0.9995606701401955 0.002594770860009443 11.964528457514836 0.12274850136510024 3.7256580842644755 0.0716643748240524 1.0000000000002045e-14 13.999999999999911 -1.4278156814655558 TPALIVYGDQDPMGQTSFEHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPALIVYGDQDPMGQTSFEHLK 22 0 Q96IU4;F8W9U3;Q96IU4-2 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 24719900.0 4426700.0 9479200.0 10814000.0 False True 5803446.568223773 8064940.3096322 9695071.015212769 1.0 1.3896811515059042 1.6705712547259797 22.468478516132663 -6.9746762133985465 0.09389854896015805 0.23081588398276134 2.836536235995263 0.9999998039247096 0.00012161544792976468 0.07481237317530938 0.002745608457871528 0.02753436210618155 0.04822940849100119 1.0600437422293692e-07 6.9746762133985465 2.6057203520125016 TPALIVYGDQDPMGQTSFEHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPALIVYGDQDPMGQTSFEHLK 22 0 Q96IU4;F8W9U3;Q96IU4-2 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 24402300.0 4426700.0 9417600.0 10558000.0 False True 6063370.6170694195 9001499.292161413 8064417.848835513 1.0 1.48457019381607 1.3300222529912331 22.531688577655554 -9.981064285604287 4.66718728199078 0.9999942840404927 1.4072962232576773 0.9025385822704888 0.06309393273625905 21700824.935384158 0.027974397793637473 1667.6241241834443 0.0215987313608284 1.0445655879671296e-10 9.981064285604287 0.4073019392171846 TPALIVYGDQDPMGQTSFEHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPALIVYGDQDPMGQTSFEHLK 22 0 Q96IU4;F8W9U3;Q96IU4-2 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 14355200.0 8232800.0 2599300.0 3523100.0 False True 6845937.974879914 2585297.054979344 4259763.921026097 1.0 0.3776395673559536 0.6222323276454776 22.70681679071976 -10.28253299316138 5.6539542776203024 1.0000439035849156 0.49993594750073467 0.8478665568751454 0.099854576248061 5.526627545607302e-05 7.013043251956856e-06 0.09669223391697687 0.032227925904274556 5.217554651994055e-11 10.28253299316138 -0.5001079560841809 TPALIVYGDQDPMGQTSFEHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPALIVYGDQDPMGQTSFEHLK 22 0 Q96IU4;F8W9U3;Q96IU4-2 Q96IU4 ABHD14B Alpha/beta hydrolase domain-containing protein 14B 0 14681400.0 7073100.0 7608300.0 0.0 False True 9156267.381645165 7184891.416766783 0.0 1.0 0.7846965490730162 0.0 23.126328162464727 -7.275110177354818 0.8352214787681042 0.9890257842629341 1.620253281316327e-17 0.9885474026869526 0.04598962488338374 0.10120338275169807 0.13766536599294021 0.039088538293968814 0.06899233012250676 5.3074977978689243e-08 7.275110177354818 -0.9890257842629341 down TPALK(ub)YQQLFEDIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPALKYQQLFEDIR 14 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 88707600.0 56134300.0 30593500.0 1979800.0 True False 46678157.621137686 30428686.743165728 2393767.0264390674 1.0 0.6518827711697524 0.05128238020592048 25.476244283455113 -7.49981429787864 0.6197726371065049 1.0000173600455018 1.5497551764635927e-24 0.9927681420456239 0.03332370143759293 0.11572878952129949 0.10546984150013197 0.031193194393173952 0.07210492181660731 3.163630123215868e-08 7.49981429787864 -1.0000173600455018 down TPALVNAAVTYSKPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPALVNAAVTYSKPR 15 1 E9PN17;A0A3B3ITX4;O75964;A0A3B3IRW3 E9PN17 ATP5L ATP synthase subunit g, mitochondrial 0 12351500.0 0.0 4966400.0 7385100.0 False True 0.0 4225432.47887558 6620960.694881435 0.0 TPALVNAAVTYSKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPALVNAAVTYSKPR 15 1 E9PN17;A0A3B3ITX4;O75964;A0A3B3IRW3 E9PN17 ATP5L ATP synthase subunit g, mitochondrial 0 6075800.0 0.0 1713800.0 4362000.0 False True 0.0 2398129.2773489333 3219461.3428049865 0.0 TPALVNAAVTYSKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPALVNAAVTYSKPR 15 1 E9PN17;A0A3B3ITX4;O75964;A0A3B3IRW3 E9PN17 ATP5L ATP synthase subunit g, mitochondrial 0 8123100.0 0.0 3815300.0 4307800.0 False True 0.0 3646727.43049009 3290386.3619258907 0.0 TPALVNAAVTYSKPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPALVNAAVTYSKPR 15 1 E9PN17;A0A3B3ITX4;O75964;A0A3B3IRW3 E9PN17 ATP5L ATP synthase subunit g, mitochondrial 0 2139500.0 0.0 2139500.0 0.0 False True 0.0 2127974.088842503 0.0 0.0 TPALVNAAVTYSKPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPALVNAAVTYSKPR 15 1 E9PN17;A0A3B3ITX4;O75964;A0A3B3IRW3 E9PN17 ATP5L ATP synthase subunit g, mitochondrial 0 28399200.0 5606700.0 17672000.0 5120500.0 False True 7257983.674579732 16688537.665063493 4188621.5407668166 1.0 2.299335244237764 0.5771053957364206 22.791137381083644 -6.704872933234437 1.8133230272546783 1.8029420294875869 0.5817021899067488 0.4408139617821747 0.5479913839048586 0.3854667376275838 2.4673280903292523 0.2407804554795273 0.6155650344561246 1.9729999160152417e-07 6.704872933234437 -1.221239839580838 TPAQYDASELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPAQYDASELK 11 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YMW4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 29011000.0 4554600.0 14965000.0 9491400.0 False True 5971124.7068091445 12732280.333113132 8509320.975937711 1.0 2.1323085613324966 1.4250784221997819 22.509571269007058 -10.092595477298586 4.773540220908989 0.9999656994618727 1.7786934917686998 0.6177962400870771 0.28872549530034475 200830554.5441251 1.7999790031014105 80116.22440540635 0.09883841668400517 8.079872779419131e-11 10.092595477298586 0.7787277923068271 TPAQYDASELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPAQYDASELK 11 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YMW4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 30979200.0 8302400.0 4993800.0 17683000.0 False True 8038844.856503999 6987850.3823229745 13051291.821371052 1.0 0.8692605103168902 1.6235282623736202 22.93855677725538 -6.862210074819592 1.1746216299736858 0.9286147970424979 1.6616076950054244 0.956264787049697 0.06882594137425414 0.14453644297838886 0.3777080493545675 0.04566039873749691 0.1068567755497685 1.3733774908186957e-07 6.862210074819592 0.7329928979629264 TPAQYDASELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPAQYDASELK 11 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YMW4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 101676000.0 15282000.0 74295000.0 12099000.0 False True 23183911.263851557 61036476.780515574 9707627.346819926 1.0 2.6327083504535267 0.418722588968674 24.466620642331236 -6.709107261927779 1.7981836604850274 2.004656844377368 0.42401473825779024 0.4609392460456093 0.6881105785686752 0.376880587111944 2.3749100795513955 0.3045755581780928 0.7746628392711834 1.953856833173186e-07 6.709107261927779 -1.5806421061195777 TPAQYDASELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPAQYDASELK 11 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YMW4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 25685000.0 4554600.0 9709400.0 11421000.0 False True 6238558.703436967 9280406.60330785 8723595.022878425 1.0 1.4875882466562442 1.398335006140504 22.57278133052995 -10.033596632117037 4.849684393059008 0.9999908879800782 1.4429616264055738 0.9704504800481409 0.036437482883742156 25196881.436979536 0.05198593848619504 2563.8474976498164 0.012473519567584157 9.255574222826468e-11 10.033596632117037 0.4429707384254956 TPAQYDASELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPAQYDASELK 11 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YMW4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 17005500.0 8302400.0 6451300.0 2251800.0 False True 6903813.458682718 6416545.566417206 2722640.9688531593 1.0 0.9294204724415476 0.3943676904289724 22.718962052689655 -6.931111876906234 0.7376097233483169 1.0078101656492309 0.28134838697995257 0.9967522617496946 0.015409899562182675 0.09206464734815753 0.07488226627460924 0.014133150276613623 0.04812048068050694 1.1718934397662537e-07 6.931111876906234 -0.7264617786692783 down TPAQYDASELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPAQYDASELK 11 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YKS4;H0YNP5;H0YMM1;H0YKX9;H0YMT9;H0YLV6;H0YKZ7;H0YMW4 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 43945000.0 15282000.0 14295000.0 14368000.0 False True 19782850.25325551 13499470.683685074 11753171.428129595 1.0 0.6823824934662067 0.5941091034743827 24.237746964423685 -13.999999999994667 0.17963930609732046 2.6461571145434317 0.5237272358445673 0.9994985766538667 0.0039029777522349447 12.200083480999716 0.13435649027894153 7.009252701089581 0.06611062867282717 1.0000000000122788e-14 13.999999999994667 -2.1224298786988642 TPCNAGTFSQPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPCNAGTFSQPEK 13 0 O43684-2;O43684;J3QT28;J3QSX4 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 10929500.0 2154900.0 4724900.0 4049700.0 False True 2825094.768081282 4019963.337515952 3630675.891465424 1.0 1.422948137150878 1.2851518938358548 21.42986783301048 -9.985274269273956 4.951911693728712 0.9999966562607301 1.3540500154995294 0.8979825032006622 0.05625508078703562 2.076694515804717e-06 4.255077808690344e-07 0.05446926225499547 0.01815624924926401 1.0344886514418365e-10 9.985274269273956 0.3540533592387993 TPCNAGTFSQPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPCNAGTFSQPEK 13 0 O43684-2;O43684;J3QT28;J3QSX4 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 8414700.0 3237100.0 2067900.0 3109700.0 False True 3134340.032398951 2893623.253956038 2295176.2809996945 1.0 0.9232001710233482 0.7322678003263801 21.57973027001696 -6.955580950300867 0.4937895760980196 1.0040384392320536 0.6432809028677015 0.9995695832571573 0.0023352802888548666 0.08131911139619497 0.027264268242987878 0.0027717626993383126 0.0157479117005855 1.1076920779145972e-07 6.955580950300867 -0.36075753636435215 TPCNAGTFSQPEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPCNAGTFSQPEK 13 0 O43684-2;O43684;J3QT28;J3QSX4 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 51697300.0 7161800.0 37778000.0 6757500.0 False True 10864974.19771311 31036220.739138793 5421877.163082535 1.0 2.8565388351931276 0.4990234734495501 23.37318141260321 -6.6966889585738105 1.8424008375191037 2.1565073916320907 0.5063637321500152 0.4020970040422739 0.7841447251144017 0.4023945160558812 2.653068272081579 0.3398262290010723 0.8776229816146904 2.0105322389743007e-07 6.6966889585738105 -1.6501436594820755 TPCNAGTFSQPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPCNAGTFSQPEK 13 0 O43684-2;O43684;J3QT28;J3QSX4 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 13101700.0 2154900.0 4386500.0 6560300.0 False True 2951624.763982853 4192689.925784287 5010892.253619587 1.0 1.4204684744976763 1.697672520831546 21.49307789453337 -8.453262952924131 0.09133780026016046 4.514655962712267e-16 2.709116839185387 0.9999858514654396 0.001078838427848259 0.1321367179855652 0.021713564434801297 0.32023758721418827 0.29771166519555275 3.521575851043306e-09 8.453262952924131 2.7091168391853864 TPCNAGTFSQPEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPCNAGTFSQPEK 13 0 O43684-2;O43684;J3QT28;J3QSX4 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 5752200.0 3237100.0 1318100.0 1197000.0 False True 2691792.0778451758 1310999.1336776356 1447287.1656973227 1.0 0.48703580951434855 0.5376667750860981 21.360135545451236 -10.540077065956808 9.77844673651094 1.000015515835353 0.5123512928734547 0.9919798514450823 0.020670005139201447 6.992009367889664e-06 3.28869434851902e-07 0.020014280843823746 0.006671215472512404 2.8835197744781847e-11 10.540077065956808 -0.48766422296189826 TPCNAGTFSQPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPCNAGTFSQPEK 13 0 O43684-2;O43684;J3QT28;J3QSX4 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 20181700.0 7161800.0 6438100.0 6581800.0 False True 9271091.28018355 6079814.075455257 5383979.934971003 1.0 0.6557819238011955 0.5807277452309164 23.14430773469566 -13.999999999999998 0.21403911416725385 3.0245317352635652 0.5382138821297499 0.9994926602642389 0.0041117064245567644 12.844309115980867 0.14660910764327456 10.957309143279014 0.04323299853472241 1.0000000000000041e-14 13.999999999999998 -2.4863178531338153 TPCNAGTFSQPEK(ub)VYTLSVSGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPCNAGTFSQPEKVYTLSVSGDR 23 1 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 15209100.0 3813200.0 6677500.0 4718400.0 True False 4999142.127081334 5681243.028691135 4230185.230088759 1.0 1.1364435905742163 0.8461822293815204 22.2532491131731 -6.778880416773727 1.5402500915832296 1.0773699915364119 0.8439637657861307 0.7634043132807047 0.05767348482079102 0.25231690501448334 1.1822570710620908 0.029494333342711097 0.06965914974832586 1.6638707350293322e-07 6.778880416773727 -0.23340622575028114 TPCNAGTFSQPEK(ub)VYTLSVSGDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPCNAGTFSQPEKVYTLSVSGDR 23 1 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 70325000.0 18761000.0 14290000.0 37274000.0 True False 28461808.612820245 11739837.85172039 29906777.56222547 1.0 0.4124768742360363 1.0507686974170136 24.76252400540978 -12.055402194545524 18.719901090168896 0.9142870536575188 0.7584605072438743 0.0 0.29636131040363833 0.0 0.0 0.0 0.08629181300459782 8.802333226486255e-13 12.055402194545524 -0.15582654641364457 TPCNAGTFSQPEK(ub)VYTLSVSGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPCNAGTFSQPEKVYTLSVSGDR 23 1 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 15217300.0 3813200.0 6275900.0 5128200.0 True False 5223043.087855324 5998609.986374007 3917024.7785942606 1.0 1.1484894697349979 0.7499506920979014 22.316459174695993 -6.805788226954949 1.431964663028754 1.081337783643833 0.7436171216267963 0.8485976077630438 0.06398992297926777 0.21259853976427015 0.8599124413169423 0.03514397839520944 0.08146869641130126 1.5639100590957104e-07 6.805788226954949 -0.33772066201703665 TPCNAGTFSQPEK(ub)VYTLSVSGDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPCNAGTFSQPEKVYTLSVSGDR 23 1 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 13283100.0 5391500.0 4017000.0 3874600.0 True False 4483271.133947755 3995359.62368793 4684760.945873728 1.0 0.8911706440047061 1.044942588994958 22.096120320948653 -6.716585562939217 1.771613636798721 0.9335489553024274 1.0446578826352826 0.49634084972931736 0.04581604608494168 0.3619996612653686 2.218556696417279 0.020549276781899845 0.05179444432413166 1.9205005552389754e-07 6.716585562939217 0.11110892733285516 TPCNAGTFSQPEK(ub)VYTLSVSGDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPCNAGTFSQPEKVYTLSVSGDR 23 1 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 67368000.0 18761000.0 14348000.0 34259000.0 True False 24286484.33459799 13549521.187094327 28024213.52702478 1.0 0.5579037706907615 1.153901616262429 24.53365032750223 -6.708010250360885 1.802003174115416 0.7276669409848848 1.1524401040521137 0.4558117684666041 0.18635495982943598 0.3790732587972419 2.3981712362182437 0.08233078268340663 0.20968818206064752 1.9587984407567723e-07 6.708010250360885 0.4247731630672289 TPDGNLDQCK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPDGNLDQCK 10 0 P30825 P30825 SLC7A1 High affinity cationic amino acid transporter 1 1 12344000.0 4991200.0 4120800.0 3232000.0 True False 6543511.5348495515 3505992.702752594 2897583.6435331623 1.0 0.5357968246988356 0.44281783994742874 22.641633626199148 -13.999999999999936 0.22604807991574682 3.8777958583107943 0.39587658055557484 0.9995046587919059 0.005424225649380512 13.171343958436273 0.15057070693664065 16.975214589670138 0.0494797542885735 1.0000000000001472e-14 13.999999999999936 -3.4819192777552193 TPDGNLDQCK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPDGNLDQCK 10 0 P30825 P30825 SLC7A1 High affinity cationic amino acid transporter 1 1 19624400.0 5975900.0 7113500.0 6535000.0 True False 9065877.196810007 5844040.346970828 5243354.385607751 1.0 0.6446194030763134 0.5783615056525054 23.11201518843985 -13.999999999999998 0.2362006194835042 3.309719174953885 0.5479898665663112 0.9995188596372019 0.004060848575920706 13.492329015362708 0.15384227642156334 14.666788303765848 0.03311497511461606 1.0000000000000041e-14 13.999999999999998 -2.761729308387574 TPDGNLDQCK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPDGNLDQCK 10 0 P30825 P30825 SLC7A1 High affinity cationic amino acid transporter 1 1 11189000.0 4991200.0 3335800.0 2862000.0 True False 6836581.52210832 3188413.3259845427 2186054.544740219 1.0 0.4663753830293351 0.31975842570894497 22.70484368772204 -13.999999999999998 0.18127160753951177 3.7796289120331865 0.20480923605572207 0.999496659777966 0.006557933676996907 12.221457507198807 0.13497975876566554 11.968567247929716 0.10829789827173315 1.0000000000000041e-14 13.999999999999998 -3.5748196759774644 TPDGNLDQCK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPDGNLDQCK 10 0 P30825 P30825 SLC7A1 High affinity cationic amino acid transporter 1 1 5068100.0 2040500.0 1397500.0 1630100.0 True False 1696766.159477028 1389971.3901179703 1970946.373269177 1.0 0.8191885383583928 1.1615898644965055 20.69435632229637 -6.763240650030628 1.6003280587086033 0.8953969775451394 1.1630421877647157 0.7040143528288021 0.07608921902179568 0.2775178089045828 1.4014850386974438 0.0375019364048203 0.08983503204967484 1.7248818404829158e-07 6.763240650030628 0.2676452102195763 TPDGNLDQCK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPDGNLDQCK 10 0 P30825 P30825 SLC7A1 High affinity cationic amino acid transporter 1 1 15389100.0 5975900.0 5863700.0 3549500.0 True False 7735920.352599763 5537379.940393438 2903527.4209455773 1.0 0.7158010537857366 0.37533057330015124 22.8831415105323 -6.9687236111751645 0.2870389086280471 1.0689262785068943 0.011729436402495788 0.999970644311823 0.0013835776955186691 0.07671906779301103 0.010505258093597656 0.006044659267733865 0.030982733572080944 1.0746731261790806e-07 6.9687236111751645 -1.0571968421043985 down TPDLPEEEYVK(ub)EEIQENEEAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPDLPEEEYVKEEIQENEEAVK 22 1 Q9NYB0;A0A590UJT3 Q9NYB0 TERF2IP Telomeric repeat-binding factor 2-interacting protein 1 1 11714100.0 3715400.0 3597300.0 4401400.0 True False 3597456.6607071357 5033720.649671674 3248541.300830318 1.0 1.399244278507088 0.9030105452866712 21.778545875953537 -6.692540627681794 1.8572173649872197 1.2497015682004877 0.9046638377371209 0.3823936389346556 0.16876612845918257 0.4112458086335891 2.7520972827812056 0.07263930537366607 0.18856617785663105 2.0298286231598515e-07 6.692540627681794 -0.34503773046336683 TPDVLK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPDVLKK 7 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 13368200.0 4865400.0 5297700.0 3205100.0 True False 6378586.516600628 4507303.810272862 2873466.9974901415 1.0 0.7066305048214603 0.45048648160713706 22.604805330082606 -7.083948144112979 0.19110170312508024 1.1784618685766048 1.0626810749754077e-11 0.9999951299932179 0.0004954159252064089 0.07490805169986997 0.00664218270076069 0.010224123826543294 0.028896088058246276 8.242365251155564e-08 7.083948144112979 -1.178461868565978 down TPDVLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPDVLKK 7 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 17399600.0 5470700.0 8965000.0 2963900.0 True False 5297035.623009778 12544771.251857404 2187565.674905934 1.0 2.3682625801805464 0.4129792266080624 22.336753780237505 -6.7185710643588585 1.7643531307799742 1.8336862713060023 0.4162440474359037 0.5058418077569398 0.5758713862749877 0.35808627276150806 2.1776908393214143 0.2592332759077551 0.6518943202515489 1.9117404776013158e-07 6.7185710643588585 -1.4174422238700985 TPDVLK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPDVLKK 7 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 11618600.0 4865400.0 3751500.0 3001700.0 True False 6664269.862491159 3585746.3254484762 2292760.281952033 1.0 0.5380553908283803 0.3440377309533171 22.668015391605497 -13.999999999999998 0.1188186675537427 3.203760419360837 0.029386833544401608 0.9996987578042426 0.004775431189518995 11.96845776025742 0.10593077381844171 6.23810592241191 0.2792021765081166 1.0000000000000041e-14 13.999999999999998 -3.1743735858164355 TPEASPEPK(ub)DQTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPEASPEPKDQTLK 14 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 10656700.0 2868200.0 3997100.0 3791400.0 True False 2777150.560973304 5593162.874601139 2798318.6004380565 1.0 2.013993390635944 1.007622215288657 21.405173963146904 -6.644471684112369 2.028891060903234 1.660845911501571 1.0118785040565197 0.1718119122033851 0.4333783903516656 0.5221346101053973 4.113341165084629 0.1736448149423816 0.47976331967629027 2.267400906277187e-07 6.644471684112369 -0.6489674074450513 TPEASPEPK(ub)DQTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPEASPEPKDQTLK 14 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 12470100.0 5135600.0 3895200.0 3439300.0 True False 7034370.104371595 3723097.184296124 2627008.17460693 1.0 0.5292722914852547 0.3734532212023282 22.7459898118357 -13.999999999999996 0.15450932065362902 3.2934214675786104 0.2106011638789291 0.9995518929372003 0.005637990802173864 11.97754027154599 0.12400922333851339 8.23821569521803 0.14746958624181314 1.0000000000000082e-14 13.999999999999996 -3.0828203036996813 TPEASPEPK(ub)DQTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPEASPEPKDQTLK 14 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 11709600.0 2868200.0 7009000.0 1832400.0 True False 2385035.3828042205 6971241.125822434 2215546.3679396603 1.0 2.9229088910311902 0.9289364778038293 21.18557923858118 -6.654406089143098 1.992603362255351 2.2433830850649126 0.9372727285171707 0.2122059905500554 0.8198319153330066 0.4978142383212476 3.7934119138690905 0.33309091104780986 0.9084465629372652 2.2161232539871773e-07 6.654406089143098 -1.3061103565477419 TPEASPEPK(ub)DQTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPEASPEPKDQTLK 14 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 29603400.0 11417000.0 13325000.0 4861400.0 True False 14779531.562715482 12583452.036383625 3976675.0821763095 1.0 0.8514107489122364 0.26906638179306847 23.817097208197822 -6.945343997204608 0.6078167539619064 1.0064627188501918 0.08380121025028228 0.9987833724654283 0.011002274200340091 0.08541101454975095 0.0441276977678024 0.01120679439335091 0.04906739105432428 1.1341121490434614e-07 6.945343997204608 -0.9226615085999095 down TPEAVQK(ub)LLEQGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPEAVQKLLEQGLR 14 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 39322800.0 3309800.0 11428000.0 24585000.0 True False 3204732.2106929193 15991259.99623272 18145450.965809368 1.0 4.9898896210036625 5.66208025284147 21.611772378759078 -9.650551835352795 0.4907171846614119 4.867462353793784e-22 5.658971180790875 0.9986699710407709 0.07504232287792525 0.9520934534408967 0.21470828119127552 1.7903381527901883 0.13811503819468837 2.235878318844783e-10 9.650551835352795 5.658971180790875 TPEAVQK(ub)LLEQGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPEAVQKLLEQGLR 14 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 83558500.0 5457900.0 9463600.0 68637000.0 True False 8280033.325937404 7774746.64055572 55070866.865334205 1.0 0.938975283614033 6.651044107856835 22.981205143699484 -6.9044844411015 0.9324661735862635 0.7908400997803818 7.3083936994470875 0.9886687374020381 0.2851143066279547 0.10817973215978219 0.1593820096289106 0.22723972976074933 0.6057280475981849 1.2459928750228312e-07 6.9044844411015 6.517553599666706 up TPEAVQK(ub)LLEQGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPEAVQKLLEQGLR 14 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 22768000.0 1871800.0 6974200.0 13922000.0 True False 2563855.0434930185 6666056.78340471 10633910.332590258 1.0 2.600013132693655 4.147625412590614 21.289883265779444 -6.971532143085603 0.21851697407203444 0.27280906352412987 6.518454534656937 0.9999919932554324 0.0036362599021315003 0.07580864144657878 0.007224509360536424 0.04335844437875497 0.15735508964836695 1.0677457634125269e-07 6.971532143085603 6.245645471132807 TPEAVQK(ub)LLEQGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPEAVQKLLEQGLR 14 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 23321100.0 3309800.0 5730300.0 14281000.0 True False 2752245.3490012554 5699429.736524502 17267091.07211654 1.0 2.0708290918150634 6.273819693575823 21.392177654193354 -6.94530975688319 0.6081617967429628 0.953381707484962 7.609456128967178 0.9987799011444292 0.07950337752755819 0.08542558510235555 0.04419090572533801 0.08095460162717168 0.3541795431449803 1.1342015673919831e-07 6.94530975688319 6.6560744214822165 TPEEMK(ub)HSQSMIEDAQLPLEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPEEMKHSQSMIEDAQLPLEQK 22 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 1 11352400.0 3975000.0 3343900.0 4033500.0 True False 5211263.493954757 2845003.1544201076 3616152.112064052 1.0 0.545933468480419 0.6939108176469893 22.31320177205204 -10.36864732085266 5.07746481086824 1.0002367017980915 0.6199221430636621 0.8979192401840058 0.06041149982477243 0.0001619708277295205 2.0140028088770046e-05 0.05852915729110852 0.01949772772837538 4.2791023976602645e-11 10.36864732085266 -0.38031455873442943 TPEFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPEFLR 6 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 76049000.0 11659000.0 33425000.0 30965000.0 False True 15285061.905916614 28438120.289629515 27761038.83725382 1.0 1.8605171810669312 1.8162202422293066 23.865619059496808 -10.138939551364924 5.112745674418981 0.9999668066178854 1.8383687116492586 0.9979105584239982 0.0180841495572101 6.842631215615751e-06 1.1524123616624088e-06 0.01751059305267674 0.005836634171546988 7.262070297965335e-11 10.138939551364924 0.8384019050313732 TPEFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPEFLR 6 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 59840000.0 20354000.0 11669000.0 27817000.0 False True 19707873.41121633 16328492.553031111 20530893.207887713 1.0 0.8285263565645843 1.0417609642348817 24.23226877419951 -6.692690830794831 1.857264655914518 0.8927655551563943 1.0410401197523862 0.38285110947318013 0.0724826372619239 0.4109170372432611 2.750296593353743 0.031199568743529436 0.08095909047978375 2.0291267172559816e-07 6.692690830794831 0.14827456459599186 TPEFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPEFLR 6 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 197022000.0 38337000.0 125580000.0 33105000.0 False True 58160031.810121484 103169267.83898152 26561782.239563063 1.0 1.77388602839497 0.4567016456641718 25.793524722538713 -6.747479693030591 1.6592026770162247 1.4564242585781992 0.45458217002670154 0.6380607371577505 0.3251590161869497 0.30445255503124374 1.6482508192799525 0.15486442818236212 0.3769647568960833 1.7886291608139192e-07 6.747479693030591 -1.0018420885514976 TPEFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPEFLR 6 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 72890000.0 11659000.0 27576000.0 33655000.0 False True 15969647.372628024 26357601.13836259 25706382.146482196 1.0 1.650481098508131 1.6097025530158502 23.9288291210197 -10.181109909313035 4.806996947629835 0.9999270589848968 1.6300918257643928 0.9968684817124421 0.016647771493256087 11681349.511189844 1.2508721132669303 9431.584391572438 0.00569897498563386 6.590070955583726e-11 10.181109909313035 0.6301647667794961 TPEFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPEFLR 6 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 43293500.0 20354000.0 15509000.0 7430500.0 False True 16925252.835087217 15425449.938704547 8984183.19524977 1.0 0.9113866769970209 0.5308153020098428 24.012674049633787 -6.943244453536406 0.6286546685717478 1.0041515597148296 0.4175869123486949 0.9985587358405306 0.0077268183433703294 0.08631715301761982 0.04809977926511259 0.007721179583847728 0.03231616908120397 1.1396081499813196e-07 6.943244453536406 -0.5865646473661348 TPEFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPEFLR 6 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 106990000.0 38337000.0 31384000.0 37269000.0 False True 49628002.23524773 29637452.811246797 30486424.4122329 1.0 0.5971921390419607 0.6142988441831788 25.564651044631162 -10.195882462497943 8.16977439130741 1.0000001062472728 0.6057454916209699 0.9985899706163471 0.006983783129371686 1.351447702022368e-08 1.3320189969958775e-09 0.006762020752083089 0.0022540063127984068 6.369678866349268e-11 10.195882462497943 -0.39425461462630285 TPEIYLAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPEIYLAYR 9 0 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 0 63027000.0 19879000.0 20793000.0 22355000.0 False True 26061561.50850983 17690765.450479183 20041919.044301953 1.0 0.6788068107393586 0.7690221876289993 24.635420191444258 -10.112717821436327 7.260080360884133 1.000000099839795 0.7239144991841793 0.9258555820561549 0.03683027338874898 5.953509115804804e-08 7.2461074917856204e-09 0.03566077162090652 0.011886919622574241 7.714045187617788e-11 10.112717821436327 -0.2760856006556158 TPEIYLAYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPEIYLAYR 9 0 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 0 49175800.0 16116000.0 9352800.0 23707000.0 False True 15604406.401452404 13087421.814207688 17497425.505244788 1.0 0.8387003951005504 1.1213131121486422 23.89545014175259 -6.751906353645331 1.642729988553288 0.905369188607868 1.121958452654206 0.6570969250956389 0.06778693178365565 0.2967627038042743 1.5761933355247688 0.03258894565923463 0.07896130466703408 1.7704906857656653e-07 6.751906353645331 0.21658926404633794 TPEIYLAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPEIYLAYR 9 0 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 0 57788000.0 19879000.0 20969000.0 16940000.0 False True 27228803.50977547 20042520.244789846 12939120.890251331 1.0 0.7360778903705533 0.4751997599015333 24.69863025296715 -6.971268402612811 0.22585122424412793 1.1117604772057115 0.09209995999117376 0.9999906550726999 0.0006549255359450032 0.0758932641743532 0.0075408408151512 0.006912969746363082 0.026123743476768407 1.068394386200946e-07 6.971268402612811 -1.0196605172145377 down TPEIYLAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPEIYLAYR 9 0 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 0 39254200.0 16116000.0 13938000.0 9200200.0 False True 13401168.059853857 13862913.227523612 11123919.283081468 1.0 1.0344555911549989 0.8300708739266999 23.675855417186867 -6.863526801744038 1.1676940412376406 1.0189018537010819 0.8194812289423458 0.957790156193672 0.018355122942381265 0.14321810430767373 0.3690716581303824 0.012240763885856048 0.02869868361676601 1.3692198867112445e-07 6.863526801744038 -0.19942062475873612 TPEMIIQKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPEMIIQKPK 10 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 4903100.0 1057500.0 2418000.0 1427600.0 False True 1386392.7408445668 2057243.8252901782 1279885.6465061707 1.0 1.4838824271663023 0.9231768234205311 20.40290457500027 -6.67836911196327 1.907437941687228 1.3065984467616214 0.9253240354587945 0.31679866683852587 0.20515321626220606 0.442147025614833 3.1087115686135 0.08634285710010102 0.22822076695926283 2.097156727919662e-07 6.67836911196327 -0.3812744113028269 TPEMIIQKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPEMIIQKPK 10 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7011100.0 2084400.0 1495000.0 3431700.0 False True 2018231.8629428744 2091961.296322006 2532834.821206754 1.0 1.0365316962500153 1.2549771251324484 20.944660496148177 -6.9359061815388126 0.6966003131122744 0.9972904259979183 1.3074091126447434 0.9975771369478676 0.005541427168419028 0.08968464682021109 0.06349072549534099 0.00523955136404543 0.019164562263736494 1.1590277080622683e-07 6.9359061815388126 0.31011868664682507 TPEMIIQKPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPEMIIQKPK 10 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 15189900.0 2461700.0 11102000.0 1626200.0 False True 3734578.874376608 9120761.35967809 1304780.8572112212 1.0 2.442246279026726 0.34937831040695877 21.83251413761249 -6.7212581440198935 1.7545776905181838 1.8762439869538203 0.35235740511825425 0.5185636341155013 0.6068092536536609 0.3528683429387013 2.123651263873918 0.27452070868931816 0.6881867395629775 1.8999486174764864e-07 6.7212581440198935 -1.523886581835566 TPEMIIQKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPEMIIQKPK 10 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5454700.0 1057500.0 2318100.0 2079100.0 False True 1448486.3278629489 2215678.677068403 1588059.4004085895 1.0 1.5296510808889343 1.096357880541104 20.466114636523162 -13.689844141972038 11.852544914971753 1.0550552782141107 1.2816935513280994 0.0 0.24164954251409512 0.0 0.0 0.0 0.06635556817597983 2.0424708076710363e-14 13.689844141972038 0.22663827311398865 TPEMIIQKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPEMIIQKPK 10 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5413890.0 2084400.0 2448300.0 881190.0 False True 1733270.9545767782 2435110.5219505 1065442.7548377814 1.0 1.40492201494549 0.6147006340955711 20.725065771582454 -6.767395927680052 1.5842448688822193 1.2330193437501387 0.6106669990518981 0.7205873968682417 0.17054570015395687 0.2706495028317656 1.3401558330479408 0.08487088221968528 0.20252893057033733 1.7084570777576935e-07 6.767395927680052 -0.6223523446982405 TPEMIIQKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPEMIIQKPK 10 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5624600.0 2461700.0 1279400.0 1883500.0 False True 3186719.1773615386 1208200.2653170123 1540722.3263420165 1.0 0.3791360951727627 0.4834823028296035 21.603640459704938 -10.274784890559808 7.255710757369683 1.0000031111791796 0.4313091990022004 0.9753718150619612 0.04259916089229252 2.1439112619281253e-06 2.1431477002456015e-07 0.04124668562821116 0.013748820058188262 5.3114746056363335e-11 10.274784890559808 -0.5686939121769792 TPEQCPSVVSLLSESYNPHVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPEQCPSVVSLLSESYNPHVR 21 0 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 12290100.0 2238900.0 5771800.0 4279400.0 False True 2935219.581538442 4910669.938300185 3836608.7389034065 1.0 1.6730162094811136 1.3070942845415734 21.48503700361245 -10.05164839470059 4.3190790396184 0.999962120720292 1.4900552469792998 0.7051363935191451 0.1493870005774259 19329029.620373365 11245953.285881106 6587.083091330469 0.05113914389274458 8.87874545363288e-11 10.05164839470059 0.4900931262590078 TPEQCPSVVSLLSESYNPHVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPEQCPSVVSLLSESYNPHVR 21 0 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 12908000.0 2238900.0 4884800.0 5784300.0 False True 3066681.8339975015 4668973.384126538 4418167.471397919 1.0 1.522483790905823 1.4406996586400747 21.548247065135342 -10.663860820957348 6.488478844995494 0.9968257066334842 1.4815917247729482 0.9788286754932787 0.03338823218456226 0.0015397886551880978 7.976953965475848e-05 0.03246795664630134 0.010776005600843014 2.1683989037240694e-11 10.663860820957348 0.48476601813946396 TPFGAYGGLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPFGAYGGLLK 11 0 P42765;A0A0B4J2A4 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 37327200.0 11391000.0 8187200.0 17749000.0 False True 11029398.940118156 11456391.655683985 13100004.441413505 1.0 1.0387140512265534 1.1877351170754884 23.394850835944236 -6.945757945449451 0.603625317209935 0.9983339719885114 1.2357912429352704 0.9988249007750494 0.0027743352052661385 0.0852352411852811 0.04336659537723992 0.0028373348534632037 0.012538352923821034 1.1330316838539539e-07 6.945757945449451 0.23745727094675906 TPFGAYGGLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPFGAYGGLLK 11 0 P42765;A0A0B4J2A4 P42765 ACAA2 3-ketoacyl-CoA thiolase, mitochondrial 0 27820300.0 11391000.0 8159300.0 8270000.0 False True 9472121.206862448 8115344.231405764 9999218.76384031 1.0 0.8567610204909842 1.055647256350139 23.175256111378513 -6.713407102111668 1.782695050130707 0.9122511260082362 1.0552364746110845 0.4814606559200856 0.06032873308610444 0.368254664936054 2.283282994189041 0.02690755235335851 0.06808622515019373 1.9346076371761587e-07 6.713407102111668 0.14298534860284828 TPFLLVGTQIDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPFLLVGTQIDLR 13 0 P60953;A0A590UJK8;P60953-1;Q5JYX0 P60953 CDC42 Cell division control protein 42 homolog 0 4091300.0 1890900.0 929100.0 1271300.0 False True 1830874.4145263284 1300094.4751924945 938308.3918175087 1.0 0.7100948404092731 0.5124919461285178 20.804101404831986 -8.060023261082613 0.12301711914410897 1.43466975170113 1.9707834666973053e-13 0.9999750327355629 0.001000377187524514 0.09889819691937032 0.021566833982425614 0.10951864856358311 0.12418674611911255 8.709169418536636e-09 8.060023261082613 -1.4346697517009328 TPFLLVGTQIDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPFLLVGTQIDLR 13 0 P60953;A0A590UJK8;P60953-1;Q5JYX0 P60953 CDC42 Cell division control protein 42 homolog 0 44546000.0 8781000.0 15953000.0 19812000.0 False True 13321418.977089398 13106062.508642085 15896149.516091922 1.0 0.9838338191436146 1.1932774986981964 23.66724442846579 -6.888264691958327 1.0326138818625208 0.988273699268466 1.2106895174979329 0.9797633982562579 0.013535807836905072 0.12056153599403438 0.23017265390018407 0.0100100189584316 0.024803749186911205 1.293407300781813e-07 6.888264691958327 0.22241581822946688 TPFLLVGTQIDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPFLLVGTQIDLR 13 0 P60953;A0A590UJK8;P60953-1;Q5JYX0 P60953 CDC42 Cell division control protein 42 homolog 0 27432700.0 8781000.0 7521700.0 11130000.0 False True 11367177.599387271 7103110.782894299 9104454.203443926 1.0 0.6248790186296711 0.8009423732356118 23.43837075055824 -10.095376414890564 5.122955409708619 1.0000066630139555 0.712910695932021 0.7799853374708264 0.07187756353336809 5.470160046945075e-06 9.660488976765178e-07 0.06959676590181157 0.023198383877248163 8.028299858703234e-11 10.095376414890564 -0.2870959670819344 TPGFSVQSISDFEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPGFSVQSISDFEK 14 0 Q9NY61 Q9NY61 AATF Protein AATF 0 6054200.0 1749000.0 1783700.0 2521500.0 False True 2292955.937340094 1517578.912808144 2260599.367935914 1.0 0.6618439055434213 0.9858887085978135 21.128777200914612 -10.654691834866115 9.277440904968946 1.000110221506949 0.8238663073044185 0.2826012654971548 0.1322907368806548 0.0003017834212185008 1.1232270035125879e-05 0.12816940304511004 0.0426966517330236 2.2146656267557157e-11 10.654691834866115 -0.1762439142025306 TPGGVFLNLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPGGVFLNLLK 11 0 Q9H814 Q9H814 PHAX Phosphorylated adapter RNA export protein 0 7102000.0 1792600.0 2556200.0 2753200.0 False True 2350115.9595630914 2174824.9239895614 2468325.274559255 1.0 0.9254117504882107 1.0502993541723533 21.164300513416247 -6.744916197338859 1.6684656670051472 0.9558758231771816 1.0504575250513015 0.6269149403875652 0.03133779009695319 0.3089853160310323 1.6906170982085407 0.01484725137279681 0.036242333703150297 1.7992180637146879e-07 6.744916197338859 0.09458170187411996 TPGGVFLNLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPGGVFLNLLK 11 0 Q9H814 Q9H814 PHAX Phosphorylated adapter RNA export protein 0 5271300.0 2426700.0 1594400.0 1250200.0 False True 2349665.736808423 2231052.2346861595 922735.1148039398 1.0 0.9495189889080233 0.39270909914926927 21.16402410307236 -6.924646077049269 0.7895001700994886 1.0103532918360674 0.2925654293417415 0.9953772748249916 0.01870789598496947 0.09551463507684174 0.09200819089518898 0.01652901148661846 0.05194349980764547 1.1894711774844177e-07 6.924646077049269 -0.7177878624943259 down TPGGVFLNLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPGGVFLNLLK 11 0 Q9H814 Q9H814 PHAX Phosphorylated adapter RNA export protein 0 11072300.0 1792600.0 5235100.0 4044600.0 False True 2455372.6631934945 5003795.971839344 3089348.781151744 1.0 2.0378967506021395 1.2581995505047656 21.22751057493914 -10.143761674219258 4.546212099821952 0.9999328679955426 1.6480481503884377 0.47946176073225 0.31831004919815115 222531334.10870555 31.36079091422437 193291.4098371783 0.10896599636341564 7.181883000348591e-11 10.143761674219258 0.6481152823928951 TPGGVFLNLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPGGVFLNLLK 11 0 Q9H814 Q9H814 PHAX Phosphorylated adapter RNA export protein 0 5699000.0 2426700.0 1583000.0 1689300.0 False True 2017908.5710379346 1574472.0647991009 2042524.8195593057 1.0 0.7802494559945562 1.0121988918996014 20.944429378506637 -11.069053972827582 11.085983268875538 1.6048217305184629 0.8962241739470785 0.21067015537744382 0.09469296068229209 0.041981486759602615 0.00026150073044779346 0.0027192001198047084 0.03056202164379924 8.529940998583458e-12 11.069053972827582 -0.7085975565713843 TPGK(ub)EAVAMESYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPGKEAVAMESYAK 14 1 P78371;F5GWF6;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 1 11896700.0 2240600.0 4427500.0 5228600.0 True False 3399154.009801453 3637378.032784611 4195164.9182232125 1.0 1.0700833272915082 1.2341791240192306 21.696744298706914 -6.956850004348357 0.4777623119510595 0.9959770873218594 1.3151011412562679 0.9996349417791807 0.0018750575990812445 0.08084614358565184 0.025439133151489525 0.002303304842936235 0.01353770306835037 1.1044600099513064e-07 6.956850004348357 0.31912405393440846 TPGK(ub)EAVAMESYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPGKEAVAMESYAK 14 1 P78371;F5GWF6;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 1 27178900.0 2240600.0 4137100.0 20801200.0 True False 2900500.8688289686 3906866.74819682 17015595.038335834 1.0 1.3469627919036464 5.866433353355833 21.467870620799363 -6.922244190459095 0.8079037062758236 0.9081157899412964 6.6342464231225104 0.9947820310068096 0.16013231479496895 0.09686927241742005 0.09890203919124745 0.13963603523663604 0.4276903778348309 1.196067829970685e-07 6.922244190459095 5.726130633181214 up TPGPGAQSALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPGPGAQSALR 11 0 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 27732000.0 5847000.0 11626000.0 10259000.0 False True 7665473.622428549 9891446.117793057 9197497.091276836 1.0 1.290389427321424 1.199860249256577 22.869943502972006 -10.081133609340096 4.3873964737630935 0.9999779109341906 1.2451248382710465 0.9071963447658075 0.03695838225841993 25678172.36663654 0.14118091719613632 5914.85383872453 0.012651837271056617 8.295955057865044e-11 10.081133609340096 0.24514692733685584 TPGPGAQSALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPGPGAQSALR 11 0 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 29841400.0 8499800.0 8293600.0 13048000.0 False True 8229978.501555288 11605277.73055264 9630337.368390508 1.0 1.410122484324776 1.170153405208845 22.97245723135138 -10.19196948178684 4.613771300136269 0.9999457351407337 1.2901379447694488 0.6609151009616704 0.0979669663223941 5.469588943246143e-05 9.579413939675986e-06 0.09487381725976544 0.03161870241913657 6.427328810727664e-11 10.19196948178684 0.29019220962871506 TPGPGAQSALR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPGPGAQSALR 11 0 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 75270000.0 14224000.0 50314000.0 10732000.0 False True 21578847.91369091 41335073.59492373 8610815.495997291 1.0 1.915536629214495 0.3990396304027925 24.363114506165655 -6.743226067276046 1.6747662029044497 1.5426769225913872 0.39748320935893733 0.6194421553120031 0.3846526606158209 0.3119820893570225 1.7193469531459231 0.18160413457976976 0.4440924096921371 1.806233665940211e-07 6.743226067276046 -1.14519371323245 TPGPGAQSALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPGPGAQSALR 11 0 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 26792000.0 5847000.0 10748000.0 10197000.0 False True 8008793.909233731 10273117.821116941 7788678.613807123 1.0 1.2827297015687418 0.9725157997669504 22.933153564494898 -6.666797319063351 1.9482227982763904 1.1809495017493299 0.9737702494515534 0.2652254453348182 0.12018474157101351 0.4684660472716348 3.424696411513088 0.04971255582713161 0.1334010795115298 2.1537866511287e-07 6.666797319063351 -0.20717925229777645 TPGPGAQSALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPGPGAQSALR 11 0 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 20455200.0 8499800.0 7264600.0 4690800.0 False True 7067960.304985464 7225464.157889794 5671624.59219131 1.0 1.0222842016802547 0.8024414891225078 22.752862506785657 -6.881931790175351 1.0690125010860103 1.0141965103378885 0.7862754060538355 0.9752086412548886 0.015556664842193148 0.12593058546491293 0.2620870974143467 0.011190198681649662 0.027197528017940373 1.3124060079104935e-07 6.881931790175351 -0.227921104284053 TPGPGAQSALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPGPGAQSALR 11 0 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 0 39334000.0 14224000.0 11431000.0 13679000.0 False True 18413248.396957614 10794854.801343435 11189562.358392589 1.0 0.5862547752914173 0.607690838529144 24.134240828258104 -10.154297278110977 5.253820447031449 1.0000145266039944 0.5969728069100609 0.9978827977451293 0.008751236171867797 1.4891033742218333e-06 2.3969393531080114e-07 0.00847365315599948 0.0028244493292503684 7.009753108500222e-11 10.154297278110977 -0.40304171969393343 TPGTWNHITDQIGMFSFTGLNPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPGTWNHITDQIGMFSFTGLNPK 23 0 P17174;P17174-2 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 4148000.0 1271200.0 1006100.0 1870700.0 False True 1666555.5103183105 855993.8017470835 1677137.9090215003 1.0 0.5136305370251901 1.0063498627184453 20.668437941454116 -10.990723087511387 9.784572529708795 1.1947414288473595 0.7599901998718175 0.2403360884951572 0.20115182239277876 0.07728564271942967 7.327575744352441e-05 0.01761500794487686 0.064921471515542 1.0215906571726712e-11 10.990723087511387 -0.43475122897554197 TPGTWNHITDQIGMFSFTGLNPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPGTWNHITDQIGMFSFTGLNPK 23 0 P17174;P17174-2 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 51498800.0 18843000.0 8551800.0 24104000.0 False True 18244839.279136747 11966578.337047847 17790439.295500085 1.0 0.6558883941900114 0.9750943279529858 24.12098510632529 -10.468077287809436 8.55788354762853 1.0000051746868701 0.8154913615932886 0.3081892767861045 0.13031527676465537 1.2866473478974578e-05 7.997614188620054e-07 0.1261807614481156 0.04205907472216002 3.403476154512757e-11 10.468077287809436 -0.1845138130935815 TPGTWNHITDQIGMFSFTGLNPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPGTWNHITDQIGMFSFTGLNPK 23 0 P17174;P17174-2 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 49855000.0 18843000.0 11158000.0 19854000.0 False True 15668789.38643748 11097889.639310421 24005379.60547593 1.0 0.7082799676225454 1.5320506909266645 23.901390381759565 -6.810986495973282 1.4104344549789327 0.8412015985859065 1.5467829346792807 0.8623790226792214 0.1265167687288765 0.20545605401690198 0.8053700956680886 0.07052924074006345 0.1630729421231369 1.5453024886906236e-07 6.810986495973282 0.7055813360933743 TPHVLVLGSGVYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPHVLVLGSGVYR 13 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 13716000.0 3814500.0 4933600.0 4967900.0 False True 5000846.439670548 4197526.11102218 4453869.36346176 1.0 0.839363128154503 0.8906231009475223 22.253740874404222 -10.00486327664846 6.26081270737161 1.0000000794312278 0.8649931145510084 0.902429306265791 0.020926796261989716 2.3192187648392674e-08 3.7133767661066037e-09 0.02026229512834322 0.006754094451011204 9.888643571187378e-11 10.00486327664846 -0.13500696488021946 TPHVLVLGSGVYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPHVLVLGSGVYR 13 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 6104800.0 1677800.0 1466900.0 2960100.0 False True 1624539.157381286 2052640.8197824438 2184761.008903491 1.0 1.2635219104790594 1.3448497064393743 20.631599087678524 -13.185923710516574 0.17456223639338705 2.374931618208028e-07 1.4157739087465755 0.9994921135552943 0.003317077992987538 8.875132425557995 0.12629435521470922 3.0851018648514077 0.0635172119294812 6.517428711316104e-14 13.185923710516574 1.4157736712534137 TPHVLVLGSGVYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPHVLVLGSGVYR 13 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 18556800.0 3898700.0 8198800.0 6459300.0 False True 5914612.933148675 6735660.0824832255 5182616.523788241 1.0 1.138816716937293 0.8762393384598455 22.495852327458355 -6.763076915464925 1.600816969069489 1.0803262912139313 0.8751302164196325 0.7033664156328776 0.05841571423967651 0.2778115604168386 1.4037718162012387 0.028781975628927595 0.06896109656209996 1.7255322655654334e-07 6.763076915464925 -0.2051960747942988 TPHVLVLGSGVYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPHVLVLGSGVYR 13 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 10827800.0 3814500.0 2545200.0 4468100.0 False True 5224823.7329865 2432744.648149131 3412826.803408025 1.0 0.4656127694395115 0.6531946296793556 22.316950935927114 -10.31491814039836 6.31330077696341 1.0000208407187698 0.5594036995594344 0.8803247939086365 0.07657997376494807 2.246503372491584e-05 2.4377787217460785e-06 0.07415174091335283 0.02471608025372033 4.842636372048687e-11 10.31491814039836 -0.4406171411593355 TPHVLVLGSGVYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPHVLVLGSGVYR 13 0 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 12214600.0 3898700.0 4816800.0 3499100.0 False True 5046944.004866328 4548740.845692499 2862299.7037979043 1.0 0.9012861726435927 0.5671352210442673 22.266978649550804 -6.948709163081971 0.5728390107337707 1.0041108493627664 0.44798493710790893 0.9990960578994003 0.005568889683793221 0.0840082354693741 0.03813960930191176 0.00588097175415305 0.02786104484727026 1.1253583480034983e-07 6.948709163081971 -0.5561259122548574 TPHYGSQTPLHDGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPHYGSQTPLHDGSR 15 0 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 4700680.0 1617750.0 355120.0 2727810.0 False True 1566395.4117615784 496921.26792633586 2013314.728454117 1.0 0.31723871520250113 1.28531704915423 20.5790170134856 -6.717206444402702 1.7694017235731447 0.583379376132768 1.2835722511745005 0.49927505689047547 0.2874115478854356 0.36077968821921014 2.205914040514438 0.12905314543649407 0.32503677685112303 1.917756907087949e-07 6.717206444402702 0.7001928750417324 TPHYGSQTPLHDGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPHYGSQTPLHDGSR 15 0 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 13724300.0 1509000.0 10648600.0 1566700.0 False True 2289263.322677133 8748274.132108457 1257041.0582909945 1.0 3.8214363745093176 0.5491028689617815 21.126451987862566 -6.678559912163785 1.9067730061735122 2.787429516070586 0.5616222866228944 0.3176496128745584 1.1961652385228752 0.44172792105493125 3.1037710830514187 0.5035759283740487 1.3307156506627418 2.0962355786610295e-07 6.678559912163785 -2.2258072294476916 TPHYGSQTPLHDGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPHYGSQTPLHDGSR 15 0 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 3540260.0 1617750.0 1428300.0 494210.0 False True 1345230.8034765795 1420605.4644046463 597547.0260311395 1.0 1.0560310251097957 0.4441966571735159 20.359422288919877 -6.884512876725253 1.0542779497186285 1.0373273858179899 0.39689620644454243 0.9771483036915071 0.04174707071105549 0.12370902668826797 0.24874945213493121 0.03036765943381871 0.07435757430332818 1.3046292861269331e-07 6.884512876725253 -0.6404311793734474 down TPHYGSQTPLHDGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPHYGSQTPLHDGSR 15 0 O00267;O00267-2 O00267 SUPT5H Transcription elongation factor SPT5 0 5755500.0 1509000.0 2062400.0 2184100.0 False True 1953430.2468369661 1947625.6270046972 1786616.2107584828 1.0 0.9970284990510063 0.9146045596720989 20.897578309955016 -6.914536788970987 0.8642729466211911 1.0022005954760655 0.9028506619826034 0.9925238649710726 0.0034217475015798915 0.10149368527496364 0.12306103566619607 0.0028658593398143634 0.00818325158125324 1.2174838557407338e-07 6.914536788970987 -0.0993499334934621 TPIAAGHPSMNLLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPIAAGHPSMNLLLR 15 0 P50213-2;P50213;H0YLI6;H0YMU3;H0YKD0 P50213-2 IDH3A Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0 21437000.0 5370800.0 8886100.0 7180100.0 False True 7041170.810901179 7560328.517746508 6437172.1283825785 1.0 1.0737317302459934 0.9142189986950059 22.747383910493404 -6.780992928023229 1.5317374729725413 1.0416945921908294 0.9129098845254128 0.7709749014565688 0.031194202092553684 0.24903447391017633 1.1541037405417294 0.016038177984610318 0.03781626775742774 1.655796925962827e-07 6.780992928023229 -0.1287847076654166 TPIAAGHPSMNLLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPIAAGHPSMNLLLR 15 0 P50213-2;P50213;H0YLI6;H0YMU3;H0YKD0 P50213-2 IDH3A Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0 28815200.0 7441100.0 12888000.0 8486100.0 False True 11288692.71727821 10588035.705596393 6808818.615410236 1.0 0.9379328475644121 0.6031538625361657 23.428375089250714 -6.938129496350704 0.6767449869836272 1.003907184494254 0.5176358383059492 0.9979084337526013 0.00797125186182937 0.08863057821686599 0.058574797594250876 0.0076535354669474065 0.02905925809576894 1.1531093765906611e-07 6.938129496350704 -0.4862713461883048 TPIAAGHPSMNLLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPIAAGHPSMNLLLR 15 0 P50213-2;P50213;H0YLI6;H0YMU3;H0YKD0 P50213-2 IDH3A Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0 16882000.0 5370800.0 5052100.0 6459100.0 False True 7356529.900412598 4828881.516939418 4933593.609340162 1.0 0.6564075158137516 0.6706414132923536 22.810593972016296 -9.809337650194774 6.319112532352836 1.0000000100698756 0.663524464559786 0.99865964489136 0.005810964312783541 8.290601432430699e-10 1.459454568832554e-10 0.005626442169661453 0.0018754806673268458 1.5511805473145447e-10 9.809337650194774 -0.3364755455100896 TPIAAGHPSMNLLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPIAAGHPSMNLLLR 15 0 P50213-2;P50213;H0YLI6;H0YMU3;H0YKD0 P50213-2 IDH3A Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0 10699700.0 4492700.0 2440700.0 3766300.0 False True 3735879.110356499 2427551.464658983 4553815.9165963475 1.0 0.6497939020375133 1.218940919146015 21.83301634083027 -6.740224896165268 1.6857025543544055 0.7916790153736166 1.2192999385867163 0.6059578719007224 0.14714199173632073 0.31744323709965994 1.7712268941929061 0.0690483442492667 0.16940777957320985 1.818758784007476e-07 6.740224896165268 0.42762092321309964 TPIGSFLGSLSLLPATK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPIGSFLGSLSLLPATK 17 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 663690000.0 305330000.0 156000000.0 202360000.0 False True 295637466.2791924 218291613.52925298 149355845.33012742 1.0 0.7383760126096602 0.5051993145857894 28.139253873610034 -6.9724861352858944 0.18962090283302657 1.158819240645647 0.0783885544070696 0.9999958384019104 0.0004122695627469707 0.07550391104489448 0.006046581353058075 0.008258827606756109 0.025445574325587382 1.0654028757748085e-07 6.9724861352858944 -1.0804306862385773 TPIGSFLGSLSLLPATK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPIGSFLGSLSLLPATK 17 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 581050000.0 155310000.0 218740000.0 207000000.0 False True 235616624.68189886 179704137.97657925 166086359.26867685 1.0 0.7626971917588332 0.7049008510876794 27.81186609580533 -13.999999999999996 0.19838168044044555 2.3110985401089956 0.6667610424575401 0.9994869324234663 0.002892239903986187 12.49933395064979 0.14123505464620226 6.354583674489651 0.03725068728554724 1.0000000000000082e-14 13.999999999999996 -1.6443374976514555 TPIGSFLGSLSLLPATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPIGSFLGSLSLLPATK 17 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 237300000.0 76980000.0 15890000.0 144430000.0 False True 105441586.30627884 15187927.258796839 110318608.62922068 1.0 0.14404114914090996 1.046253309474835 26.651868739214052 -11.97275666075745 14.367509929551684 0.9375765181595613 0.6356325097247915 0.0 0.4254547273046135 0.0 0.0 0.0 0.12319549489239236 1.0647394345403975e-12 11.97275666075745 -0.3019440084347699 TPIGSFLGSLSLLPATK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPIGSFLGSLSLLPATK 17 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 600070000.0 305330000.0 134560000.0 160180000.0 False True 253895423.41245842 133835098.57193111 193672897.41135952 1.0 0.5271268649632695 0.7628057836108918 27.91965914904431 -10.117597542041953 5.309483222430031 1.000007331088398 0.6449663242868446 0.7516005068207547 0.0962155156370913 8.349816892613132e-06 1.3877349975989555e-06 0.09316219503160687 0.031053424142315024 7.627855511619548e-11 10.117597542041953 -0.35504100680155326 TPIGSFLGSLSLLPATK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPIGSFLGSLSLLPATK 17 0 P24752;A0A5F9ZHL1;A0A5F9ZHJ7;A0A5F9ZHH9;P24752-2;A0A5F9ZHL7;E9PRQ6 P24752 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 730290000.0 155310000.0 320150000.0 254830000.0 False True 201051856.61779264 302333371.0655318 208453554.77660525 1.0 1.503758165438279 1.0368148709657705 27.582992417897778 -10.521028061553325 3.0160819821751845 0.9902940294325493 1.2702865184648582 0.3087929293595135 0.19062880457065334 35113784.425247364 40682479.39736981 2800641.6231433484 0.07532443081219713 3.0128113477597574e-11 10.521028061553325 0.2799924890323089 TPK(ub)DKEEIVICDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPKDKEEIVICDR 13 2 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 25394600.0 10681000.0 12025000.0 2688600.0 True False 14002894.43495112 10230916.873082867 2410409.4628723 1.0 0.7306287225551437 0.17213651606598818 23.739221731049447 -7.195375491738588 0.5260774235870197 1.0077901996063112 2.349606529956875e-21 0.9989004372780736 0.011432640900930102 0.08696540119042866 0.04127620709195349 0.012262417412951893 0.04925689998079303 6.377118810019721e-08 7.195375491738588 -1.0077901996063112 down TPK(ub)DKEEIVICDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPKDKEEIVICDR 13 2 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 22703400.0 11377000.0 8434200.0 2892200.0 True False 11015843.362454947 11802020.04377196 2134646.055859829 1.0 1.0713678159219766 0.19377963044893098 23.39307661483408 -6.887195749014885 1.0388625147776573 1.0503726326699636 0.1223281929671146 0.9790405949406165 0.05761201752504885 0.12144648942252326 0.23539174516876085 0.042404021273070316 0.10469782763372507 1.2965947267202755e-07 6.887195749014885 -0.928044439702849 down TPK(ub)DKEEIVICDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPKDKEEIVICDR 13 2 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 49638000.0 31924000.0 11094000.0 6620000.0 True False 48431041.957021065 9114189.02218237 5311554.098350928 1.0 0.18818899313111068 0.10967251340709407 25.529428705971156 -13.999999999999998 0.33032676756383067 9.854520672318504 0.0958204388671017 0.9997155200325756 0.006788378731569932 18.850918450952882 0.1838049510024062 115.98316598791763 0.025130172656505217 1.0000000000000041e-14 13.999999999999998 -9.758700233451401 TPK(ub)DKEEIVICDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPKDKEEIVICDR 13 2 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 22623200.0 10681000.0 9197900.0 2744300.0 True False 14630054.34317177 8791506.364612157 2096152.8606326268 1.0 0.6009209643650697 0.14327717529025832 23.80243179257234 -7.617248562687733 0.4384906738881073 1.0302913110714005 3.020373319029586e-15 0.9978396363100517 0.016269196197838034 0.11933013520374494 0.06658534081184206 0.02444816437528404 0.07269276285866604 2.4140787730066845e-08 7.617248562687733 -1.0302913110713974 down TPK(ub)DKEEIVICDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPKDKEEIVICDR 13 2 Q9NRR5;Q9NRR5-2 Q9NRR5 UBQLN4 Ubiquilin-4 1 27475800.0 11377000.0 14745000.0 1353800.0 True False 9460479.58655729 14665565.758346664 1636873.3207360378 1.0 1.5501926328539892 0.17302223484123633 23.173481890268356 -6.798277673629401 1.4628899126705162 1.304226527747 0.1547958978067546 0.8271096252468646 0.23534323727473583 0.22321381653512762 0.9432361141485146 0.1265706162797532 0.29467664387466896 1.5911910464500309e-07 6.798277673629401 -1.1494306299402455 down TPK(ub)EK(ub)EEFAVPENSSVQQFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPKEKEEFAVPENSSVQQFK 20 2 Q9UHD9;Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UHD9;Q9UMX0-2 UBQLN2;UBQLN1 Ubiquilin-2;Ubiquilin-1 2 25646400.0 12103500.0 11688700.0 1854200.0 True False 15867805.710460737 9944791.52219574 1662345.1707423234 1.0 0.6267275831112368 0.10476213290451586 23.919599302182284 -7.538129966387859 0.5164711423844588 1.0122772389633452 1.0925101934022924e-22 0.9963269053587429 0.02225187191196336 0.1168059064445166 0.07891240635704819 0.024363031007202426 0.07074266116535655 2.8964766622445787e-08 7.538129966387859 -1.0122772389633452 down TPK(ub)EK(ub)EEFAVPENSSVQQFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPKEKEEFAVPENSSVQQFK 20 2 Q9UHD9;Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UHD9;Q9UMX0-2 UBQLN2;UBQLN1 Ubiquilin-2;Ubiquilin-1 2 54575300.0 10338100.0 26413500.0 17823700.0 True False 10009922.674289834 36960548.29458284 13155138.270461543 1.0 3.6923909901436924 1.3142097794871177 23.254927493745136 -6.6162286131838 2.1301967689624073 2.7911215478958127 1.3230032693093414 0.07040615570769915 1.1589228943038192 0.595597279312042 5.130047073625557 0.44780817947186 1.285885333786056 2.4197549492493686e-07 6.6162286131838 -1.4681182785864713 TPK(ub)EK(ub)EEFAVPENSSVQQFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPKEKEEFAVPENSSVQQFK 20 2 Q9UHD9;Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UHD9;Q9UMX0-2 UBQLN2;UBQLN1 Ubiquilin-2;Ubiquilin-1 2 80716300.0 23374300.0 44796000.0 12546000.0 True False 35460521.99022674 36801803.80725452 10066277.600892853 1.0 1.0378246495468244 0.28387279814062566 25.079710437536935 -6.895093150719186 0.9917875593027846 1.0357045904819988 0.21217244551334283 0.983962286249547 0.04392446689312311 0.11510713512672989 0.19849684420561145 0.033499521323631494 0.08519903678505397 1.2732299598704023e-07 6.895093150719186 -0.823532144968656 down TPK(ub)EK(ub)EEFAVPENSSVQQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPKEKEEFAVPENSSVQQFK 20 2 Q9UHD9;Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UHD9;Q9UMX0-2 UBQLN2;UBQLN1 Ubiquilin-2;Ubiquilin-1 2 17655100.0 12103500.0 1953100.0 3598500.0 True False 16578491.034788856 1866805.5839619925 2748608.413433848 1.0 0.11260407114523424 0.16579364235659788 23.982809363705176 -10.674304049500051 6.016447222888451 1.009448662536413 0.13919885675091606 0.9971446013840546 0.02171455151754514 0.002735316217587376 0.00014807418000931414 0.020896855079623057 0.007008341366484602 2.116878589968615e-11 10.674304049500051 -0.8702498057854969 TPK(ub)EK(ub)EEFAVPENSSVQQFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPKEKEEFAVPENSSVQQFK 20 2 Q9UHD9;Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UHD9;Q9UMX0-2 UBQLN2;UBQLN1 Ubiquilin-2;Ubiquilin-1 2 43826700.0 10338100.0 27066100.0 6422500.0 True False 8596588.205483684 26920289.547099754 7765415.055715169 1.0 3.1315085593988963 0.9033136018730875 23.035332769179412 -6.65620075841115 1.986145925010374 2.3762552516606963 0.9125908356136726 0.2197326435948973 0.9083695889296076 0.4934706782268178 3.7379088629143538 0.3700048933689663 1.0067476769010981 2.2069842892848525e-07 6.65620075841115 -1.4636644160470236 TPK(ub)EKEEFAVPENSSVQQFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPKEKEEFAVPENSSVQQFK 20 2 Q9UHD9;Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UHD9;Q9UMX0-2 UBQLN2;UBQLN1 Ubiquilin-2;Ubiquilin-1 1 218256100.0 78478000.0 98065000.0 41713100.0 True False 102885417.98203318 83434084.25437604 37397028.55230921 1.0 0.8109417825269086 0.3634823018247331 26.616463281702412 -6.956624183910813 0.4806539462529612 1.0106744650453439 0.1450732158263708 0.9996237831982011 0.00517686069162818 0.0809298067758962 0.025760059581201707 0.006317443494903363 0.03691079422180117 1.1050344462087198e-07 6.956624183910813 -0.8656012492189731 down TPK(ub)EKEEFAVPENSSVQQFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPKEKEEFAVPENSSVQQFK 20 2 Q9UHD9;Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UHD9;Q9UMX0-2 UBQLN2;UBQLN1 Ubiquilin-2;Ubiquilin-1 1 262568400.0 160760000.0 94041000.0 7767400.0 True False 155656761.79557496 131592061.71733648 5732884.92299482 1.0 0.8453989418728701 0.0368302980022407 27.2137930085501 -7.148977860769697 0.8450991648916478 0.9951347418110641 1.188604164821699e-19 0.993199367581666 0.03482911162375215 0.08504760713409686 0.11078740509940381 0.03021034764125627 0.06153880669128432 7.096139413588606e-08 7.148977860769697 -0.9951347418110641 down TPK(ub)EKEEFAVPENSSVQQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPKEKEEFAVPENSSVQQFK 20 2 Q9UHD9;Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UHD9;Q9UMX0-2 UBQLN2;UBQLN1 Ubiquilin-2;Ubiquilin-1 1 201611600.0 78478000.0 113411000.0 9722600.0 True False 107493437.38820678 108400127.01997532 7426322.123232431 1.0 1.008434837082138 0.06908628381110064 26.679673343225303 -6.946057137965875 0.9834150455911068 1.030283963292269 2.2854628838287066e-17 0.988582864192163 0.04710403273285479 0.09684610038036823 0.1676715728654742 0.03736716024013513 0.08690191813656199 1.1322513887496625e-07 6.946057137965875 -1.030283963292269 down TPK(ub)EKEEFAVPENSSVQQFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPKEKEEFAVPENSSVQQFK 20 2 Q9UHD9;Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UHD9;Q9UMX0-2 UBQLN2;UBQLN1 Ubiquilin-2;Ubiquilin-1 1 230106700.0 160760000.0 52125000.0 17221700.0 True False 133679062.87553391 51844192.27899755 20822677.845855977 1.0 0.3878258207664779 0.15576618655116983 26.994198283984375 -10.346112514734449 0.22140881175325042 1.7158590661160984 6.302951691670979e-22 0.9992636403803747 0.009663425416399914 1.9725611098620144 0.10900262274386967 0.9237469612602879 0.12187395649847055 4.5069992444434787e-11 10.346112514734449 -1.7158590661160984 TPK(ub)GTQGVVTNFEIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPKGTQGVVTNFEIFR 16 1 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 11394600.0 4119400.0 4957600.0 2317600.0 True False 5400573.292326347 4217945.404573449 2077796.9839890029 1.0 0.7810180838702274 0.3847363736256179 22.364681132543875 -6.961952602432523 0.406981460211032 1.020175586211249 0.13094450393169824 0.9998359008481208 0.0032618737330685093 0.07901085588926281 0.01860740129616324 0.005099531233523724 0.03311961892026854 1.0915594593991225e-07 6.961952602432523 -0.8892310822795507 down TPK(ub)GTQGVVTNFEIFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPKGTQGVVTNFEIFR 16 1 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 18426200.0 6698900.0 6306700.0 5420600.0 True False 6486247.086292478 8824998.199006021 4000782.245485718 1.0 1.3605707709865191 0.6168100277802637 22.62895255201075 -6.774884567831968 1.5557956075447026 1.205521383638899 0.6118358472288762 0.7488738447585469 0.15218453983309685 0.25860540947756133 1.2359524273248501 0.0770735032576531 0.18265447689687697 1.6792502907591153e-07 6.774884567831968 -0.5936855364100228 TPK(ub)GTQGVVTNFEIFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPKGTQGVVTNFEIFR 16 1 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 57479000.0 14850000.0 11049000.0 31580000.0 True False 22528535.68042112 9077219.623768965 25338199.15799432 1.0 0.40292097775612223 1.124715761265167 24.425250207911375 -6.687014855209114 1.8768102920366978 0.624630948295749 1.122149377527693 0.35657098384044605 0.2526770277470717 0.42312542661497937 2.8872223449083783 0.10779246335081206 0.281781920941936 2.0558202746614702e-07 6.687014855209114 0.497518429231944 TPK(ub)GTQGVVTNFEIFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPKGTQGVVTNFEIFR 16 1 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 20127900.0 6698900.0 7264500.0 6164500.0 True False 5570432.161588178 7225364.6966096405 7453468.4485723935 1.0 1.297092305769976 1.338041328277723 22.409357827445028 -12.507891677142354 0.30393603803775665 1.6099662789322458e-10 1.3482586885669943 0.9995527300150148 0.0031856948791348905 7.005404237084495 0.16970664713865924 4.356048107609832 0.014550947873087418 3.105334032022024e-13 12.507891677142354 1.3482586884059977 TPK(ub)GTQGVVTNFEIFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPKGTQGVVTNFEIFR 16 1 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 43910200.0 14850000.0 8228200.0 20832000.0 True False 19223617.737262417 7770293.436830891 17040789.754370525 1.0 0.404205573739079 0.8864507184482362 24.196376530003825 -10.066106708422657 7.257052310084111 1.0000000592262532 0.6453281460936731 0.41901040818453195 0.1968757559120118 1.8878293512942135e-07 2.4267753831083125e-08 0.19062416506586963 0.06354137699326816 8.588024833239241e-11 10.066106708422657 -0.3546719131325802 TPK(ub)PGELGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPKPGELGGR 10 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 6653700.0 3297200.0 1995200.0 1361300.0 True False 5002093.457608383 1639140.9714312495 1092238.4583210142 1.0 0.32769099284581554 0.21835626774619254 22.25410058197472 -13.999999999999998 0.25560727725969357 5.8109663243804475 0.17668125493297773 0.9995535064464254 0.007302546988225344 14.227363167611847 0.15998000161061682 35.26215664489295 0.04893180769133711 1.0000000000000041e-14 13.999999999999998 -5.634285069447469 TPK(ub)PGELGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPKPGELGGR 10 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 3637640.0 1409000.0 1654600.0 574040.0 True False 1929945.3767932835 1581494.3009694903 438463.574724904 1.0 0.8194502911772742 0.22718962930103068 20.88012858482549 -6.949426927522759 0.5650986349879018 1.0075490735137305 0.010536841014148417 0.9991555509243515 0.009592081054701081 0.08371665110427717 0.036920818871420305 0.010219976273861009 0.04928931107108431 1.1234999889332509e-07 6.949426927522759 -0.997012232499582 down TPKEK(ub)EEFAVPENSSVQQFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPKEKEEFAVPENSSVQQFK 20 2 Q9UHD9;Q9UMX0-2;Q9UMX0;Q9UMX0-4 Q9UHD9;Q9UMX0-2 UBQLN2;UBQLN1 Ubiquilin-2;Ubiquilin-1 1 692176000.0 405620000.0 199500000.0 87056000.0 True False 615355194.7941009 163897666.29938543 69849343.44199975 1.0 0.26634644134957847 0.1135106098606537 29.196844161168812 -13.999999999999865 0.22049042872388716 5.436723389277871 0.0321415753792252 0.9994983885571421 0.008666063811488383 13.01299420717453 0.14875088672808243 25.144963785592598 0.08431026048392783 1.0000000000003108e-14 13.999999999999865 -5.404581813898646 TPLHASVINGHTLCLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPLHASVINGHTLCLR 16 0 H7C209;A0A2R8Y7Y4;Q8N8A2-4;Q8N8A2;Q8N8A2-2 H7C209 ANKRD44 Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B 0 8286800.0 2611600.0 1925800.0 3749400.0 False True 3423832.8907703785 1638478.1467096056 3361448.054784421 1.0 0.4785508519199196 0.9817792404079859 21.707180858230224 -10.8035721026284 10.330089839260427 1.0025233667710882 0.7301650461639528 0.2771214864404138 0.2054421293131378 0.012007659443336456 0.00022832662169210925 0.20005866711110656 0.0663061621199311 1.5719107983361062e-11 10.8035721026284 -0.2723583206071354 TPLHEIALSIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPLHEIALSIK 11 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 103013000.0 33809000.0 33745000.0 35459000.0 False True 44323926.40682177 28710377.53697977 31790042.82674578 1.0 0.647739942383828 0.71722081963057 25.401582351481874 -10.800749874427748 7.147153043927755 1.011959125495892 0.6824803810071991 0.9653321037905216 0.028365449355911943 0.005400021961749563 0.00015054296622069531 0.027437643094888615 0.009154909413594746 1.582158998316195e-11 10.800749874427748 -0.32947874448869285 TPLHEIALSIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPLHEIALSIK 11 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 61774000.0 18937000.0 10765000.0 32072000.0 False True 18335855.300589744 15063520.638733393 23671381.06062387 1.0 0.8215335686167254 1.2909886488830722 24.128164228277996 -6.8036610938163955 1.440718054780324 0.901985956451658 1.2980863969207521 0.8427198575594288 0.07673162641472103 0.21556209137456123 0.8828945779963132 0.041890044774261045 0.09722062159467343 1.571588731434162e-07 6.8036610938163955 0.3961004404690941 TPLHEIALSIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPLHEIALSIK 11 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 160771000.0 40571000.0 67428000.0 52772000.0 False True 61549173.13739834 55394946.58263145 42341591.069210745 1.0 0.9000112228798167 0.6879311111895874 25.87523613962821 -6.958879420568144 0.4509483916906782 1.0067732327612797 0.5727482651918808 0.9997263538843543 0.0021523415354639565 0.0801038639627349 0.02262882830877232 0.0028386981838505825 0.017540084643946907 1.0993110146150784e-07 6.958879420568144 -0.4340249675693989 TPLHEIALSIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPLHEIALSIK 11 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 109314000.0 33809000.0 25875000.0 49630000.0 False True 46309100.95387092 24731756.942817338 37908416.16193464 1.0 0.5340582398145227 0.8185953814930609 25.464792413004766 -10.355259165045538 5.986409156565906 1.00004471201983 0.6763268106537922 0.6330730745790907 0.11616180166373824 6.93291964358367e-05 7.4667483305879686e-06 0.11248867384073559 0.03749106027575876 4.413070189867168e-11 10.355259165045538 -0.32371790136603773 TPLHEIALSIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPLHEIALSIK 11 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 50676000.0 18937000.0 14287000.0 17452000.0 False True 15746954.551343549 14210033.095252529 21101132.511069097 1.0 0.9023988129844518 1.3400135526058734 23.908569503712272 -6.8481681723074725 1.2438841682934918 0.9479871823348438 1.3569007816227954 0.9376022159830194 0.046854088649639185 0.15948042006826665 0.4757625298409696 0.029488297529567754 0.0681632115349138 1.41850812493606e-07 6.8481681723074725 0.40891359928795157 TPLHEIALSIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPLHEIALSIK 11 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 133111000.0 40571000.0 52851000.0 39689000.0 False True 52519959.27397128 49909795.39023715 32466009.243529804 1.0 0.9503014869048515 0.6181651641078071 25.64636246172066 -6.933598654165599 0.7166374493042758 1.004439073213956 0.5432789376278859 0.9971994381808733 0.008970169552505495 0.09081193610657197 0.06883873068934188 0.008354793269107654 0.029480592696091875 1.1652023338628551e-07 6.933598654165599 -0.46116013558607016 TPLLLMLGQEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPLLLMLGQEDR 12 0 C9JIF9;P13798 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 1764290.0 640990.0 1123300.0 0.0 False True 877981.3251034255 1073668.8917436418 0.0 1.0 1.2228835181854971 0.0 19.743830728016114 -6.907435386127578 1.2835885851248077 1.1163906479829462 6.91730028562732e-20 0.9518361251716704 0.11670613464351526 0.12974639599329096 0.4286401464640215 0.07444875809799942 0.14723660159509763 1.2375552984040748e-07 6.907435386127578 -1.1163906479829462 down TPLQVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPLQVAK 7 0 B1AJY7;O75832;B1AJY5 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 2626150.0 475250.0 1255800.0 895100.0 False True 623057.3523275468 1068439.5350700603 802483.6384054873 1.0 1.7148333633793187 1.287977158776251 19.24900544364151 -10.229692186529943 4.673332102084401 0.999874024972381 1.5014052610800568 0.6478534364562993 0.17426331581087803 0.0002287849113252814 3.771031885266963e-05 0.16877180570174802 0.05624324333143367 5.892611560722982e-11 10.229692186529943 0.5015312361076758 TPLQVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPLQVAK 7 0 B1AJY7;O75832;B1AJY5 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 3240170.0 1118400.0 784370.0 1337400.0 False True 1082897.0041812088 1097573.0314355146 987094.8188600157 1.0 1.0135525605829914 0.9115315815342658 20.046464602092065 -6.873435135976965 1.1158255646344986 1.0078487852571585 0.9051549760941109 0.9679899923962307 0.008093753805339367 0.13360066750793853 0.308820197395886 0.005617017818033279 0.013383129226879925 1.338335087174334e-07 6.873435135976965 -0.1026938091630476 TPLQVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPLQVAK 7 0 B1AJY7;O75832;B1AJY5 B1AJY7 PSMD10 26S proteasome non-ATPase regulatory subunit 10 0 2813650.0 475250.0 1151400.0 1187000.0 False True 650962.7681483374 1100527.340829369 906655.0470323691 1.0 1.690614877959637 1.3927909419633138 19.312215505164403 -10.105825003417708 4.5524889945718465 0.9999586304962031 1.5417029099649524 0.8151929478151548 0.12158611281676024 14285980.05046996 31712681.664759967 3887.5056317525177 0.041622163087419194 7.83745385057951e-11 10.105825003417708 0.5417442794687493 TPLRPLDPTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPLRPLDPTR 10 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 8423200.0 2140600.0 3762900.0 2519700.0 False True 2806347.3295998885 3201489.987669322 2258985.6146690934 1.0 1.1408031906463163 0.8049558195603556 21.420262145524006 -6.792792419379004 1.4849413123580024 1.0784080616104685 0.801092300506993 0.8103338061439295 0.059970979289770826 0.23119805994827836 1.0070126821855983 0.031782431667717014 0.07426896423863742 1.6114156627750431e-07 6.792792419379004 -0.27731576110347556 TPLRPLDPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPLRPLDPTR 10 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 8943300.0 2423400.0 2057800.0 4462100.0 False True 2346470.493502093 2879490.2712852387 3293342.14986935 1.0 1.22715809947715 1.4035301781928895 21.16206088814087 -6.97395471174448 0.13331909173264786 0.7397970227682631 1.8954675385446247 0.9999991294816485 0.00015400252828012522 0.07503932274541214 0.0040137197029854466 0.010702628042290241 0.023702177968734986 1.0618062766501203e-07 6.97395471174448 1.1556705157763616 TPLRPLDPTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPLRPLDPTR 10 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 26866900.0 6178900.0 20688000.0 0.0 False True 9373843.038097907 16996064.763918243 0.0 1.0 1.8131373327717892 0.0 23.16020920689195 -6.794295021003997 1.5419277734238968 1.4570141347075172 3.375437275825635e-20 0.7836047027362164 0.3449422821426391 0.23703736518709956 1.1230551985426915 0.1777680448472233 0.4040294822260964 1.605850010886447e-07 6.794295021003997 -1.4570141347075172 TPLRPLDPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPLRPLDPTR 10 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 8699500.0 2140600.0 2686300.0 3872600.0 False True 2932037.667539887 2567610.3835938256 2957971.6387005467 1.0 0.8757085258553883 1.0088450334208767 21.483472207046898 -11.14519161738439 9.986416324731975 2.6266513963286178 0.9422767796381325 0.2004075948135624 0.05435275161193982 0.043090861890644504 0.0006264953097940882 0.0011520360920670683 0.017542275151132602 7.158275064557094e-12 11.14519161738439 -1.6843746166904854 TPLRPLDPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPLRPLDPTR 10 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 5615100.0 2423400.0 2033800.0 1157900.0 False True 2015164.4748231457 2022843.515722307 1400011.5364752985 1.0 1.003810627368188 0.6947380990319244 20.942466163575148 -6.904108774192007 0.9349184799370174 1.0114419978915432 0.6594459358177888 0.9885021466969031 0.015527517156139528 0.10844404036201556 0.16085051851165436 0.012353353035324047 0.032857602239237435 1.247071131403111e-07 6.904108774192007 -0.35199606207375445 TPLRPLDPTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPLRPLDPTR 10 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 14563500.0 6178900.0 4763900.0 3620700.0 False True 7998707.854327987 4498784.777195337 2961769.7515192693 1.0 0.5624389412798855 0.37028102606806645 22.9313355289844 -13.999999999999998 0.11176645209152761 3.1051247597858396 0.026572330577283414 0.9997341012154334 0.004296871154036745 12.002540532584833 0.1017325493100717 5.683497316920896 0.30516457479349274 1.0000000000000041e-14 13.999999999999998 -3.078552429208556 TPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVR 43 0 P12268 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 937070000.0 737800000.0 17320000.0 181950000.0 False True 955096644.212269 16356126.774496365 148836966.96465638 1.0 0.01712510129065142 0.15583445703278753 29.831071482897876 -10.329859885983938 5.210396813404673 1.0002944572490047 0.08647977916164198 0.98300226840261 0.056627857353341464 0.00019375785169983972 2.4920435894758116e-05 0.05484666519850303 0.01827656237170278 4.678860684225073e-11 10.329859885983938 -0.9138146780873627 TPLVSVLLEGPPHSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPLVSVLLEGPPHSGK 16 0 I3L0N3;P46459;P46459-2 I3L0N3 NSF Vesicle-fusing ATPase 0 22307300.0 6809600.0 6911900.0 8585800.0 False True 8927451.544260204 5880671.4623751845 7697423.776809107 1.0 0.6587178248148645 0.8622196086584274 23.089816967606787 -10.286486817008372 5.539107149988593 1.0000267384524382 0.76046871673664 0.6487844917916914 0.08307925536050229 2.743588377841979e-05 3.5341784935642957e-06 0.0804501136232198 0.02681371436887514 5.170269520629076e-11 10.286486817008372 -0.2395580217157982 TPLVSVLLEGPPHSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPLVSVLLEGPPHSGK 16 0 I3L0N3;P46459;P46459-2 I3L0N3 NSF Vesicle-fusing ATPase 0 21056600.0 6905100.0 5510200.0 8641300.0 False True 6685901.38016065 7710451.595313394 6377884.296556786 1.0 1.1532404019887184 0.9539303579143634 22.67269064408169 -6.701354269984701 1.8264187139608776 1.0950311991093398 0.9545151994057911 0.42386594572710157 0.06466887004585602 0.39269521332744994 2.5477614323282336 0.02823979436491603 0.07249392753175886 1.989050135659671e-07 6.701354269984701 -0.14051599970354867 TPLVSVLLEGPPHSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPLVSVLLEGPPHSGK 16 0 I3L0N3;P46459;P46459-2 I3L0N3 NSF Vesicle-fusing ATPase 0 26371500.0 6809600.0 6640900.0 12921000.0 False True 9327293.142520605 6347483.079480415 9869325.91634813 1.0 0.6805278854745068 1.0581125483615974 23.153027029129678 -6.682494051105164 1.8934507270024634 0.7983167606419299 1.0566902408845962 0.3354257624384651 0.13532711089431954 0.43298319055627355 3.0034671300257823 0.05731004217267474 0.15064669919254486 2.0773321803343858e-07 6.682494051105164 0.25837348024266626 TPMENIGLQDSLLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPMENIGLQDSLLSR 15 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 13708200.0 2419600.0 5628500.0 5660100.0 False True 3172119.031439734 4788749.739721167 5074447.147513021 1.0 1.5096374670239565 1.5997026269250287 21.597015477454914 -11.696906070880976 0.29185180466468114 2.5968434913804513e-17 1.626650244468272 0.9993984699822989 0.0064760323652995 4.387291942092211 0.1589204474097904 2.747483347618898 0.033675803817101786 2.0095273857718504e-12 11.696906070880976 1.626650244468272 TPPKEEQSENLK(ub)HPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPPKEEQSENLKHPK 15 2 Q5SWX8-3;Q5SWX8-4;Q5SWX8-2;Q5SWX8 Q5SWX8-3 ODR4 Protein odr-4 homolog 1 3878710.0 400230.0 719980.0 2758500.0 True False 518105.6247127629 679912.4800867157 2256481.304600188 1.0 1.3123047650055109 4.355253440553128 18.98288672044743 -6.92662358356379 0.7740066035941409 0.9474751772164675 4.929428809943871 0.9958319862565511 0.09770861162770438 0.09442932767637006 0.08655014501305182 0.08729029710459087 0.280619549321964 1.1840673788597257e-07 6.92662358356379 3.981953632727403 up TPPVFASEGK(ub)YR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPPVFASEGKYR 12 1 Q96PZ0;Q96PZ0-2 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 1 6280790.0 1578300.0 802790.0 3899700.0 True False 1528197.7304177422 1123348.2334945458 2878251.5815076996 1.0 0.735080422601774 1.8834287764063828 20.543399792172576 -6.8459872361831895 1.254250462703518 0.8589734920513872 1.9259143098501734 0.9342687296709365 0.12587162580369674 0.16192487935488611 0.4922054931666665 0.07860221242048093 0.18148938047647992 1.4256494925033263e-07 6.8459872361831895 1.0669408177987862 TPPVFASEGK(ub)YR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPPVFASEGKYR 12 1 Q96PZ0;Q96PZ0-2 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 1 13062600.0 2369100.0 2278100.0 8415400.0 True False 3594097.904409804 1871555.2561234594 6752092.501399156 1.0 0.5207301820651968 1.8786612610398363 21.777198278195037 -6.811343725490842 1.4091505979490178 0.7392203627744954 1.9030919879683421 0.8632404168147545 0.207947576809662 0.20497607497517575 0.801990549550655 0.11603344505434952 0.26821513890108695 1.5440319206493584e-07 6.811343725490842 1.1638716251938468 TPPVFASEGK(ub)YR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPPVFASEGKYR 12 1 Q96PZ0;Q96PZ0-2 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 1 19217300.0 2369100.0 2732200.0 14116000.0 True False 3066846.6519426475 2580150.668203175 11547032.842391241 1.0 0.8413041019083292 3.7651158185809352 21.548324600287486 -6.894070510925627 0.9979742430557175 0.857884546762339 4.037616196490424 0.9833789061146039 0.1730733848677022 0.11590324776792754 0.20304445658351256 0.13138107557167605 0.3327239531041942 1.2762315863396247e-07 6.894070510925627 3.179731649728085 up TPQAPASANLVGPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPQAPASANLVGPR 14 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 7068400.0 3350100.0 2099000.0 1619300.0 False True 2785756.5845939647 2087692.2703811184 1957888.1432027388 1.0 0.7494166151941118 0.702820969366248 21.409637772151616 -13.999999999999998 0.23657621365501053 2.6315325971657155 0.6815382494366267 0.9995194443250676 0.0028608192986369872 13.504965457765127 0.15396172593628205 10.38872188507875 0.023235517732373385 1.0000000000000041e-14 13.999999999999998 -1.9499943477290889 TPQAVALSSK(ub)SGLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPQAVALSSKSGLSR 15 1 P08574 P08574 CYC1 Cytochrome c1, heme protein, mitochondrial 1 4259090.0 562570.0 877020.0 2819500.0 True False 544711.5232852498 1227218.6595988795 2080988.3668130767 1.0 2.2529698879827444 3.8203494471023385 19.055132861921095 -6.968098997381509 0.3001446899351745 0.7286308952298539 5.3938107776519795 0.999963523290362 0.006968393297473075 0.07692453917702459 0.01122652404480009 0.025984653880844925 0.14054965590798338 1.0762198614625779e-07 6.968098997381509 4.665179882422126 TPQAVALSSK(ub)SGLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPQAVALSSKSGLSR 15 1 P08574 P08574 CYC1 Cytochrome c1, heme protein, mitochondrial 1 5279370.0 562570.0 2096900.0 2619900.0 True False 467801.88107669336 2085603.5834979396 3167708.9769510585 1.0 4.458305252423766 6.771475500825811 18.83553813735537 -8.200086881824618 0.2979870054368685 6.6032975814242965e-24 8.166939696011141 0.9989487927472974 0.0768929276093785 0.09535211690203645 0.0699639302968886 0.5916927814238379 0.7031271529220753 6.308311323253667e-09 8.200086881824618 8.166939696011141 TPQAVALSSK(ub)SGLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPQAVALSSKSGLSR 15 1 P08574 P08574 CYC1 Cytochrome c1, heme protein, mitochondrial 1 6944800.0 1874300.0 1692100.0 3378400.0 True False 2426318.29797649 1597933.1475245557 2763565.865311318 1.0 0.6585834796931656 1.1389955998832004 21.210337392985494 -6.71584006221611 1.7743184039160875 0.7913706035825709 1.138076700779134 0.4928314635211718 0.14374706794252656 0.36344807325904954 2.2338214166652413 0.06438583653103684 0.16242663547451516 1.9238000770114918e-07 6.71584006221611 0.346706097196563 TPQGPPEIYSDTQFPSLQSTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPQGPPEIYSDTQFPSLQSTAK 22 0 Q9UKY7;Q9UKY7-2;H0Y8K3;D6R9V8;D6RFH2;Q9UKY7-3;D6RDN0 Q9UKY7 CDV3 Protein CDV3 homolog 0 12407300.0 1751300.0 6099300.0 4556700.0 False True 2295971.2596133277 5189308.214885182 4085216.3949528364 1.0 2.2601799535413742 1.7792977058610226 21.13067315215971 -10.331464747743034 5.2956312758528865 0.9997061181518871 2.019738829701252 0.857054840893676 0.19631935553011096 0.0006813572219488515 8.601652481052047e-05 0.19013770098987406 0.06336179954216396 4.6616026531092614e-11 10.331464747743034 1.0200327115493648 TPQGPPEIYSDTQFPSLQSTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPQGPPEIYSDTQFPSLQSTAK 22 0 Q9UKY7;Q9UKY7-2;H0Y8K3;D6R9V8;D6RFH2;Q9UKY7-3;D6RDN0 Q9UKY7 CDV3 Protein CDV3 homolog 0 10699300.0 3439700.0 2402600.0 4857000.0 False True 3330508.6062965887 3361970.7093934845 3584805.993123295 1.0 1.0094466361796557 1.0763539197424492 21.667311079278967 -6.932434721596684 0.7265285949648335 0.9990687772067232 1.0909819713727271 0.9969954515341514 0.0018629194339738059 0.09139334792475415 0.07163040883626053 0.0017224836411459763 0.00597498058062431 1.1683293271684575e-07 6.932434721596684 0.09191319416600396 TPQGPPEIYSDTQFPSLQSTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPQGPPEIYSDTQFPSLQSTAK 22 0 Q9UKY7;Q9UKY7-2;H0Y8K3;D6R9V8;D6RFH2;Q9UKY7-3;D6RDN0 Q9UKY7 CDV3 Protein CDV3 homolog 0 10149800.0 1751300.0 4152500.0 4246000.0 False True 2398802.937102966 3969028.819518809 3243182.2491149427 1.0 1.6545872768991208 1.3520002827042281 21.1938832136826 -9.999455850001853 4.3642528433354615 0.9999795871688034 1.503293779651136 0.7867243599191407 0.1235306234847253 22701863.795540582 44626229.82869363 6810.340048070179 0.04520757686071616 1.0012537369459696e-10 9.999455850001853 0.5033141924823327 TPSALAILENANVLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPSALAILENANVLAR 16 0 P09972;A8MVZ9;J3KSV6;J3QKP5;K7EKH5 P09972 ALDOC Fructose-bisphosphate aldolase C;Fructose-bisphosphate aldolase 0 2517270.0 788420.0 1190100.0 538750.0 False True 1033626.2550701409 1012541.7189734655 483005.3180549167 1.0 0.979601392676268 0.46729203683215303 19.9792831907326 -6.915290730931182 0.8589193080866825 1.0133333269979912 0.39300576109428487 0.9927697830029965 0.020956123981333098 0.10102273015103706 0.12055617683503575 0.0176191735633528 0.05061952009781029 1.215372118408356e-07 6.915290730931182 -0.6203275659037063 down TPSALAILENANVLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPSALAILENANVLAR 16 0 P09972;A8MVZ9;J3KSV6;J3QKP5;K7EKH5 P09972 ALDOC Fructose-bisphosphate aldolase C;Fructose-bisphosphate aldolase 0 7172300.0 2848600.0 1779600.0 2544100.0 False True 2758172.752244809 2490203.560491399 1877723.888635982 1.0 0.9028453922854119 0.6807854537420648 21.39528138912087 -6.957352966893231 0.4712624606779415 1.0057938348082553 0.5687143012870672 0.9996590662445103 0.002466889095027692 0.08066063549426347 0.024730777275371037 0.003077669598566869 0.018326215848008556 1.1031816596677044e-07 6.957352966893231 -0.4370795335211881 TPSFGISAPQVSIPDVNVNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPSFGISAPQVSIPDVNVNLK 21 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 106244000.0 67813000.0 12389000.0 26042000.0 False True 65660313.43395948 17335992.307781503 19220818.956746303 1.0 0.2640254272501742 0.29273114841400233 25.968518300941493 -10.62689258536014 6.520304097828689 1.002664009608434 0.2783782878320928 0.9988146025403029 0.011719061591665168 0.0004547812004698912 2.6023630701237033e-05 0.0113705814783666 0.0037823108648081796 2.3610621256495964e-11 10.62689258536014 -0.7242857217763412 TPSFGISAPQVSIPDVNVNLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPSFGISAPQVSIPDVNVNLK 21 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 232152000.0 86483000.0 78474000.0 67195000.0 False True 131201033.75419913 64469701.579839565 53913878.79738531 1.0 0.4913810488766533 0.4109257164725639 26.967203846327617 -13.999999999999998 0.25954992593521936 4.71461192160869 0.38139280580764656 0.99956141668416 0.005461881624714296 14.397240718713974 0.1612166263765259 28.042674375372748 0.03525751543864914 1.0000000000000041e-14 13.999999999999998 -4.333219115801044 TPSFGISAPQVSIPDVNVNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPSFGISAPQVSIPDVNVNLK 21 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5914200.0 2149700.0 3764500.0 0.0 False True 2944502.1834581364 3598171.942463228 0.0 1.0 1.2219966969891654 0.0 21.489592312661966 -6.907747963044734 1.2829701165251128 1.1159440144337491 5.061365132860869e-20 0.9520356208356666 0.11640553527395948 0.12955119100860793 0.4275642934441959 0.07430108339653553 0.14689700120068047 1.236664907064752e-07 6.907747963044734 -1.1159440144337491 down TPSFGISAPQVSIPDVNVNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPSFGISAPQVSIPDVNVNLK 21 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 102022000.0 67813000.0 15417000.0 18792000.0 False True 56389514.12527109 15333945.560965084 22721320.315609083 1.0 0.2719290243732237 0.40293520290196067 25.74892357637577 -10.024912426860668 6.094494724894217 1.0000000863170895 0.3374321136725378 0.9715138946194524 0.05348304842608177 5.493997099719457e-07 8.793412381670448e-08 0.05178479798949153 0.01726157965465631 9.442512602628863e-11 10.024912426860668 -0.6625679726445517 TPSFGISAPQVSIPDVNVNLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPSFGISAPQVSIPDVNVNLK 21 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 172968000.0 86483000.0 49974000.0 36511000.0 False True 111953948.33479214 47192902.96932346 29866372.634496104 1.0 0.4215385314343329 0.2667737322240959 26.738330168420067 -13.999999999999936 0.185055210790392 4.049784711797443 0.15004555860056973 0.999492904327555 0.007105976058007375 12.274332339687437 0.13640468534119138 13.477438300353501 0.1107734987702031 1.0000000000001472e-14 13.999999999999936 -3.8997391531968733 TPSLTVFLLGQSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPSLTVFLLGQSAR 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 0 15504000.0 7214900.0 4195400.0 4093700.0 False True 9458803.769190993 3569462.6735411114 3670123.193543231 1.0 0.37736935458662185 0.3880113472168093 23.173226310459686 -10.046837346982013 5.1899323628479985 1.0000069767532813 0.3826903508999946 0.9997771539108902 0.004344575304407666 3.507278722438209e-07 6.44249666338578e-08 0.00420666443156932 0.0014022056491622735 8.977649646474474e-11 10.046837346982013 -0.6173166258532867 TPSLTVFLLGQSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPSLTVFLLGQSAR 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 0 19762000.0 9249700.0 4002700.0 6509600.0 False True 8956073.336529804 5600998.983804753 4804540.476186004 1.0 0.6253855650064343 0.5364561338046849 23.09443491102682 -13.999999999999991 0.20201220568404543 3.0985597275667116 0.47983301009308627 0.9994871262901126 0.004548907495664398 12.571427126138454 0.14250702843808963 10.432983230263195 0.055787730187372195 1.0000000000000205e-14 13.999999999999991 -2.6187267174736255 TPSLTVFLLGQSAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPSLTVFLLGQSAR 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 0 64491000.0 16961000.0 22906000.0 24624000.0 False True 25731077.015193403 18818245.334605154 19757055.60691741 1.0 0.7313430884954237 0.7678285520365697 24.617008508844833 -10.541870932503494 9.475433416111972 1.0000114205611623 0.7495858203213519 0.9843280480637037 0.014895128117454462 3.5938007141677096e-06 1.737477818937352e-07 0.014422802740684087 0.004807381928210586 2.8716338729171915e-11 10.541870932503494 -0.2504256002398104 TPSLTVFLLGQSAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPSLTVFLLGQSAR 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 0 35203100.0 7214900.0 7943200.0 20045000.0 False True 9882443.505341277 7592243.159350213 15310783.839733649 1.0 0.7682556601762253 1.5492913095287066 23.236436371982577 -6.8272054421390385 1.3402628515335038 0.8759078917662897 1.5691456536705197 0.9001782277594809 0.1034795941813909 0.18429107638635292 0.6483957218040955 0.06063607305854498 0.13957324291790374 1.4886567050358448e-07 6.8272054421390385 0.69323776190423 TPSLTVFLLGQSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPSLTVFLLGQSAR 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 0 19021300.0 9249700.0 3503300.0 6268300.0 False True 7691535.381188275 3484427.0275493977 7578972.548655413 1.0 0.4530209970913615 0.9853653624465974 22.874840186461096 -10.887201411143199 10.656527518200747 1.017634631360631 0.7191931797689803 0.2706030373810743 0.2173286770943452 0.08152503261458495 0.0008629351194401064 0.18840500589500123 0.07014252891997402 1.2965778224349062e-11 10.887201411143199 -0.2984414515916507 TPSLTVFLLGQSAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPSLTVFLLGQSAR 14 0 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 0 55111000.0 16961000.0 17969000.0 20181000.0 False True 21956348.851293422 16969009.353979535 16508265.074546464 1.0 0.77285205609128 0.7518674979321064 24.388134830937283 -13.999999999999998 0.3369977302093486 3.5796138645194153 0.7484488411261125 0.9997291737703914 0.0018489414448250399 19.431650005610862 0.18603043362873617 35.655199998821374 0.006553768800204802 1.0000000000000041e-14 13.999999999999998 -2.831165023393303 TPSNELYKPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPSNELYKPLR 11 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 17449600.0 3858600.0 13591000.0 0.0 False True 5853778.301445986 11165579.863032335 0.0 1.0 1.9074142012303816 0.0 22.480936677308446 -6.784940465217237 1.5661511354056032 1.5151999397077898 4.58697663676684e-17 0.7575389578875807 0.3835843195919006 0.2496269026725438 1.217488873485774 0.19436392195405836 0.44747724721232673 1.6408146870650547e-07 6.784940465217237 -1.5151999397077898 TPSNELYKPLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPSNELYKPLR 11 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 9430600.0 3858600.0 3189700.0 2382300.0 False True 4995033.764377153 3012190.3910283567 1948745.8444622173 1.0 0.6030370430146546 0.3901366710191223 22.252062999400895 -10.322050506048676 0.12893395527414409 1.8171680702513948 8.507284934157511e-09 0.9998141381281838 0.0034454548793573935 2.0538904667276414 0.06524942330037847 0.770383095242583 0.23276353640266684 4.7637558373563084e-11 10.322050506048676 -1.81716806174411 TPSPEPVDKDFYSEFGNK(ub)TTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPSPEPVDKDFYSEFGNKTTGK 22 2 Q9Y2I1;Q9Y2I1-2 Q9Y2I1 NISCH Nischarin 1 7582400.0 2165100.0 3458800.0 1958500.0 True False 1800376.5801929508 3440166.7578819524 2368013.2949191355 1.0 1.9108039927475957 1.3152877686652364 20.779867272297775 -10.079300812032486 4.397040404889953 0.9999461606652083 1.613045880761809 0.5855755118087638 0.24311848060598326 56294881.49699964 3.825799313049164 31259.789039340376 0.08322592245710256 8.33103939200155e-11 10.079300812032486 0.6130997200966009 TPSSDAQDK(ub)QFGTWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPSSDAQDKQFGTWR 15 1 Q99598 Q99598 TSNAX Translin-associated protein X 1 17689900.0 7462400.0 3765600.0 6461900.0 True False 7225510.196711238 5269223.717344586 4769334.537155324 1.0 0.7292528242148112 0.6600688958028367 22.784668029917125 -13.999999999999998 0.19157969596760985 2.4593761815672703 0.6112168880170087 0.9994886155123791 0.0033170608768734585 12.376935457890056 0.1388048713736518 6.746416955450598 0.04698804911780634 1.0000000000000041e-14 13.999999999999998 -1.8481592935502618 TPSSDAQDK(ub)QFGTWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPSSDAQDKQFGTWR 15 1 Q99598 Q99598 TSNAX Translin-associated protein X 1 35581200.0 11044000.0 17332000.0 7205200.0 True False 14296675.70978625 16367458.963947514 5893927.531595174 1.0 1.144843689274129 0.4122586013167179 23.7691763920164 -6.855342556175189 1.2089761570498634 1.077809539889571 0.3798016677840643 0.9477290835104084 0.07242305765429698 0.15167991676167747 0.4239404165006471 0.04680150122276859 0.10874254425610896 1.3952673891861677e-07 6.855342556175189 -0.6980078721055067 down TPSSDVLVFDYTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPSSDVLVFDYTK 13 0 Q09028-3;Q09028;Q09028-2;Q09028-4;H0YF10;Q16576;E9PC52;Q16576-2;Q5JP01 Q09028-3;Q16576;Q5JP01 RBBP4;RBBP7 Histone-binding protein RBBP4;Histone-binding protein RBBP7 0 82498000.0 22126000.0 30073000.0 30299000.0 False True 29007400.26848878 25586225.62363588 27163950.12853077 1.0 0.8820585570169355 0.9364489708524283 24.789917666820013 -10.115152603062953 4.470675660222586 1.000010045296471 0.9092537639308652 0.7877540456434571 0.022204793478923027 30959287.65752569 0.5677761972936701 3201.4254051287385 0.007601291418790452 7.670919000686858e-11 10.115152603062953 -0.09075628136560587 TPSSDVLVFDYTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPSSDVLVFDYTK 13 0 Q09028-3;Q09028;Q09028-2;Q09028-4;H0YF10;Q16576;E9PC52;Q16576-2;Q5JP01 Q09028-3;Q16576;Q5JP01 RBBP4;RBBP7 Histone-binding protein RBBP4;Histone-binding protein RBBP7 0 93296000.0 32598000.0 17584000.0 43114000.0 False True 31563194.33324306 24605382.899348624 31821150.00772449 1.0 0.7795593386260555 1.0081726732648775 24.91173988399647 -11.074278195416925 10.448393432406187 1.63378552648796 0.8938660059454665 0.22322381898416221 0.0933310030435421 0.04278252720809703 0.00030414374083318244 0.0028058182298457248 0.030122451706039374 8.427947169673981e-12 11.074278195416925 -0.7399195205424934 TPSSDVLVFDYTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPSSDVLVFDYTK 13 0 Q09028-3;Q09028;Q09028-2;Q09028-4;H0YF10;Q16576;E9PC52;Q16576-2;Q5JP01 Q09028-3;Q16576;Q5JP01 RBBP4;RBBP7 Histone-binding protein RBBP4;Histone-binding protein RBBP7 0 216505000.0 31221000.0 148070000.0 37214000.0 False True 47364539.56083689 121645751.62380968 29858636.58852435 1.0 2.5682874308862025 0.630400651317907 25.49730402406458 -6.691354407596153 1.8612974996316674 1.9819291898989881 0.636913169314786 0.3769746428355826 0.6630876374906843 0.4137242634482028 2.7799180572745197 0.28486524462943746 0.7406284884847423 2.035380420180652e-07 6.691354407596153 -1.345016020584202 TPSSDVLVFDYTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPSSDVLVFDYTK 13 0 Q09028-3;Q09028;Q09028-2;Q09028-4;H0YF10;Q16576;E9PC52;Q16576-2;Q5JP01 Q09028-3;Q16576;Q5JP01 RBBP4;RBBP7 Histone-binding protein RBBP4;Histone-binding protein RBBP7 0 88977000.0 22126000.0 30305000.0 36546000.0 False True 30306580.132667236 28966024.894766387 27914587.488496162 1.0 0.9557668588130841 0.9210734885394488 24.853127728342905 -6.973852541134578 0.13798043781252142 1.0478363148807095 0.828100559525457 0.9999989587074503 3.245050172547283e-05 0.07507140077821782 0.004171004369492325 0.0020030295933175972 0.004560204786396114 1.0620561028886602e-07 6.973852541134578 -0.21973575535525247 TPSSDVLVFDYTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPSSDVLVFDYTK 13 0 Q09028-3;Q09028;Q09028-2;Q09028-4;H0YF10;Q16576;E9PC52;Q16576-2;Q5JP01 Q09028-3;Q16576;Q5JP01 RBBP4;RBBP7 Histone-binding protein RBBP4;Histone-binding protein RBBP7 0 62130000.0 32598000.0 15631000.0 13901000.0 False True 27106681.336256877 15546792.700489432 16807634.829038013 1.0 0.5735409845134611 0.6200550565574677 24.692145159430748 -10.510335046453266 9.571985987827516 1.0000082881306183 0.5967980208198895 0.9901173957193278 0.018989290394478654 3.3587677196198217e-06 1.7180123123702616e-07 0.01838667884202948 0.006128767121176036 3.0879122725119144e-11 10.510335046453266 -0.40321026731072873 TPSSDVLVFDYTK(ub)HPAKPDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPSSDVLVFDYTKHPAKPDPSGECNPDLR 29 2 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 32407000.0 1402300.0 11644000.0 19360700.0 True False 1838428.879892516 9906760.587956503 17357440.484948196 1.0 5.388710271204891 9.44145333811499 20.810041935905637 -7.550135843855807 0.30024009849184813 8.764134057823005e-19 12.569525719605572 0.9995761224631671 0.07097026438332173 0.13846501432415892 0.037442325285577144 0.32370944386570527 0.870564039069085 2.817501501384647e-08 7.550135843855807 12.569525719605572 TPSSDVLVFDYTK(ub)HPAKPDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPSSDVLVFDYTKHPAKPDPSGECNPDLR 29 2 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 29417200.0 7357400.0 6119800.0 15940000.0 True False 7123843.364237138 8563468.054335393 11764835.810250212 1.0 1.2020853935847897 1.6514731176308026 22.7642243648032 -6.957919296356755 0.46383211606676994 0.9873905693209403 1.8844003942724759 0.9996850616431 0.0048319327176323075 0.08045299389355533 0.02394264701348566 0.00614392686041512 0.03710942076435569 1.1017440243133514e-07 6.957919296356755 0.8970098249515356 TPSSDVLVFDYTK(ub)HPAKPDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPSSDVLVFDYTKHPAKPDPSGECNPDLR 29 2 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 256159000.0 26865000.0 65710000.0 163584000.0 True False 40756169.094579995 53983537.105426684 131251550.69858582 1.0 1.324548854926744 3.2204094156641543 25.280515114930363 -6.936403672432916 0.6922081275889282 0.9768277412433558 3.6817594367012907 0.9976539471169353 0.047429543230909435 0.08944619650626767 0.06237130262430252 0.04499631183661507 0.1659221988453808 1.1577007844526785e-07 6.936403672432916 2.704931695457935 up TPSSDVLVFDYTK(ub)HPAKPDPSGECNPDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPSSDVLVFDYTKHPAKPDPSGECNPDLR 29 2 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 44522300.0 1402300.0 11550000.0 31570000.0 True False 1920768.2057325887 11039682.809257595 24113816.204559285 1.0 5.747535166559578 12.554256225499204 20.87325199742853 -6.965997197828758 0.340504334155017 0.26601340729622824 18.262156966343632 0.9999322497533325 0.03903091441755007 0.07762417329866736 0.013675741473001426 0.09593881567071348 0.5889337357813202 1.0814409289893928e-07 6.965997197828758 17.996143559047404 TPSSDVLVFDYTK(ub)HPAKPDPSGECNPDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPSSDVLVFDYTKHPAKPDPSGECNPDLR 29 2 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 46705800.0 7357400.0 4118100.0 35230300.0 True False 6118004.088084426 4095914.9779211474 42596792.8434974 1.0 0.6694854921555956 6.962530954573888 22.544629640237478 -6.894509696244928 0.9953354883687113 0.6975068446472334 7.554114338854133 0.9836308222381147 0.3699850701750934 0.11555996087646715 0.2010901430988681 0.2814208610517735 0.7139806200656308 1.2749416347320284e-07 6.894509696244928 6.8566074942069 up TPSSDVLVFDYTK(ub)HPAKPDPSGECNPDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPSSDVLVFDYTKHPAKPDPSGECNPDLR 29 2 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 353207000.0 26865000.0 47213000.0 279129000.0 True False 34777272.08832016 44585555.04643749 228330386.10539997 1.0 1.282031406408423 6.565505929433839 25.051641437022813 -6.917938471209109 0.8398704780702887 0.8745378793281788 7.378394297387448 0.9935889178041261 0.20495482365742607 0.09940012415273541 0.11201037204374407 0.17468823736402755 0.5133953503042527 1.2079849645881866e-07 6.917938471209109 6.50385641805927 up TPSSDVLVFDYTK(ub)HPSKPDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPSSDVLVFDYTKHPSKPDPSGECNPDLR 29 2 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 20647200.0 3993100.0 5888100.0 10766000.0 True False 5234992.769235413 5009618.431634031 9652037.594764259 1.0 0.9569484911372097 1.8437537586463504 22.319756113778173 -6.895490002287258 0.9893167226267437 0.9584304682510192 1.9287708523018656 0.9841865305061922 0.051341261122257134 0.114802481123856 0.19672157141610216 0.03922759145671308 0.09994173650345635 1.2720670334750383e-07 6.895490002287258 0.9703403840508464 TPSSDVLVFDYTK(ub)HPSKPDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPSSDVLVFDYTKHPSKPDPSGECNPDLR 29 2 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 13559600.0 3769100.0 3839400.0 5951100.0 True False 3649451.9836010323 5372492.442206503 4392328.3808268495 1.0 1.4721367663824667 1.2035583426125247 21.79924840868682 -10.117758464351283 4.595435340508178 0.9999701855340352 1.33784755450498 0.6784342872083851 0.1096466823851237 3.349645272384194e-05 6.43070095851796e-06 0.10617430210700793 0.035388314566768324 7.625029630132265e-11 10.117758464351283 0.3378773689709448 TPSSDVLVFDYTK(ub)HPSKPDPSGECNPDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPSSDVLVFDYTKHPSKPDPSGECNPDLR 29 2 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 119911700.0 11619000.0 44180700.0 64112000.0 True False 17626872.462681018 36296308.899615385 51440235.09871212 1.0 2.0591462822721742 2.918284863501426 24.07127318408539 -6.973507141703965 0.15270302174893277 0.038261779135514144 4.961818166327238 0.9999984254738769 0.0009844425670136336 0.07518022443361458 0.0046797136759335395 0.04268593304663216 0.10601665062818781 1.0629011043811556e-07 6.973507141703965 4.9235563871917245 TPSSDVLVFDYTK(ub)HPSKPDPSGECNPDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPSSDVLVFDYTKHPSKPDPSGECNPDLR 29 2 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 24839100.0 3993100.0 7093000.0 13753000.0 True False 5469456.979470024 6779607.806585646 10504824.651925996 1.0 1.2395394701948224 1.9206339297221944 22.382966175301064 -6.952650016098896 0.5289547384408828 0.9891768635011327 2.2018601235150075 0.999393155034921 0.00960711960711192 0.08243882760848979 0.03169153068795838 0.01073477215796987 0.05631532743149424 1.1151928695009842e-07 6.952650016098896 1.2126832600138748 TPSSDVLVFDYTK(ub)HPSKPDPSGECNPDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPSSDVLVFDYTKHPSKPDPSGECNPDLR 29 2 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 141274100.0 11619000.0 35283100.0 94372000.0 True False 15041024.54473078 33319564.468662433 77197264.33849165 1.0 2.2152456682437265 5.132447201911896 23.842399506177838 -6.956325920489597 0.484445047921667 0.9328255974355383 6.537411258584396 0.9996087376461615 0.03430116076007105 0.0810406168449627 0.026186324920157603 0.04150972076518255 0.24061520417614501 1.1057936190096785e-07 6.956325920489597 5.604585661148858 TPTAPAVNLAGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPTAPAVNLAGAR 13 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 9959500.0 1794700.0 3855000.0 4309800.0 False True 2352869.0798995243 3279849.0266723065 3863863.2385207987 1.0 1.393978549291985 1.6421921948525071 21.165989616603575 -9.214156590104443 0.09285522883293819 2.1487373504257364e-21 2.4657004413648376 0.9999675383332965 0.00150649987177696 0.6768376382814807 0.03307859812934198 0.5130210025102989 0.34474511813323333 6.1072178211061e-10 9.214156590104443 2.4657004413648376 TPTAPAVNLAGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPTAPAVNLAGAR 13 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 12375900.0 4047800.0 1574800.0 6753300.0 False True 3919304.8046536963 2203625.8524735123 4984408.135342704 1.0 0.5622491646623083 1.2717582285063227 21.902166345138134 -6.739790128916783 1.6873404611412313 0.7394754638052936 1.2721641943733772 0.6040244470742135 0.1839257861405201 0.31821063528563237 1.7788023202740282 0.08623286106075864 0.21166662891106888 1.8205804343300655e-07 6.739790128916783 0.5326887305680836 TPTAPAVNLAGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPTAPAVNLAGAR 13 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 7040500.0 4047800.0 1927300.0 1065400.0 False True 3365925.047944675 1916917.2523609027 1288170.2141469733 1.0 0.5695068146367146 0.3827091203155474 21.68257162057241 -13.999999999995525 0.11368183444329946 3.065350470912649 0.057508749950463095 0.9997244193913374 0.004290776837743318 11.992261767641786 0.10289621341216498 5.648378134478374 0.28864081312217954 1.0000000000103033e-14 13.999999999995525 -3.007841720962186 TPTGDEFVK(ub)TSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPTGDEFVKTSVR 13 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 25448500.0 5327000.0 10930000.0 9191500.0 True False 6983748.586741389 9299286.604806297 8240451.751093773 1.0 1.331560907341502 1.1799467934367267 22.73557019255411 -10.162866334143684 4.307983446692265 0.9999391564662702 1.2557538503583412 0.7914083957606592 0.06189620287843898 43696003.82325642 24502960.36481267 29503.615941936343 0.022651690565818776 6.872799364283218e-11 10.162866334143684 0.255814693892071 TPTGDEFVK(ub)TSVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPTGDEFVKTSVR 13 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 46368000.0 5357400.0 6781300.0 34229300.0 True False 5187332.269492499 9489108.454012327 25263619.47301115 1.0 1.8292848734250624 4.870252792864339 22.306561352404387 -6.946873641877832 0.5921731496718848 0.9650710185263109 5.888056190972289 0.998932542904235 0.054359590310717874 0.0847659608621969 0.04134898807912681 0.05623111603459667 0.25492481686445867 1.1301246769897236e-07 6.946873641877832 4.922985172445978 TPTGDEFVK(ub)TSVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPTGDEFVKTSVR 13 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 128254800.0 21793900.0 26618000.0 79842900.0 True False 33062939.647510365 21867809.932616785 64061915.81861368 1.0 0.6613994449904708 1.9375747136095183 24.978711665500683 -6.836157346346716 1.3002310455310053 0.8196907687233523 1.9764244235128343 0.9176152484723011 0.15493338389111233 0.17334415418998492 0.5709332471473123 0.09349274709388601 0.21520515790759467 1.4582858227114747e-07 6.836157346346716 1.156733654789482 TPTGDEFVK(ub)TSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPTGDEFVKTSVR 13 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 24464200.0 5327000.0 7147200.0 11990000.0 True False 7296535.856762119 6831413.071370214 9158208.941801256 1.0 0.9362543000510511 1.255144786729694 22.798780254077002 -6.854733611952738 1.2120625808711798 0.965791595620997 1.2691032761583958 0.9469089435380844 0.03174690455128651 0.15232814799592514 0.42827027235019244 0.020468026673287152 0.04752956774250838 1.3972251298183275e-07 6.854733611952738 0.30331168053739876 TPTGDEFVK(ub)TSVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPTGDEFVKTSVR 13 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 30295040.0 5357400.0 8648600.0 16289040.0 True False 4454915.473061619 8602008.275187312 19695002.951988604 1.0 1.9309026910168563 4.420959964578926 22.086966627838663 -6.953996937305574 0.5130912174812746 0.9553127112715281 5.50636995407589 0.9994787689585203 0.03297047664229608 0.08191936921231668 0.029619047706221865 0.03777600930306414 0.20555582891534332 1.1117395673687038e-07 6.953996937305574 4.551057242804362 TPTGDEFVK(ub)TSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPTGDEFVKTSVR 13 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 153618800.0 21793900.0 16536000.0 115288900.0 True False 28212633.171994783 15615757.063687764 94307503.16400972 1.0 0.5535022898602997 3.342740203974434 24.749837987593132 -6.86591215682124 1.1555772557713133 0.7527805686203345 3.4938357983666606 0.9604261027388228 0.24334863007137283 0.14083046452141285 0.3540662629410654 0.16381222645150695 0.3852879727098842 1.3617200848237943e-07 6.86591215682124 2.741055229746326 up TPTQLEGATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPTQLEGATR 10 0 O94776;O94776-2 O94776 MTA2 Metastasis-associated protein MTA2 0 1840270.0 687970.0 0.0 1152300.0 False True 901935.3323109577 0.0 1033071.0496421003 1.0 0.0 1.1453937024455445 19.78266447210948 -10.691320295393718 4.456637942661757 1.017991294369631 0.572696851222718 0.15652191241398716 0.46760502093165235 0.08423177709518564 0.005834133312550737 0.45623666864466345 0.15091887155591263 2.0355402979563896e-11 10.691320295393718 -0.445294443146913 TPVDRDTEDGLK(ub)AVITCYDTETR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPVDRDTEDGLKAVITCYDTETR 23 2 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 140760000.0 43340000.0 62345000.0 35075000.0 True False 65749948.57841425 51219047.64629165 28142410.876081344 1.0 0.7789975316133844 0.42802179293750076 25.97048643031692 -6.964291387157205 0.3700140833706685 1.0269859807484918 0.1678161718185464 0.999897781900322 0.0023810701459263386 0.07820227931722448 0.015712975952282243 0.004626023072771599 0.029807915674215535 1.0856969376437718e-07 6.964291387157205 -0.8591698089299453 down TPVDRDTEDGLK(ub)AVITCYDTETR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPVDRDTEDGLKAVITCYDTETR 23 2 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 20872200.0 8803400.0 1963800.0 10105000.0 True False 7320417.156745928 1953220.6196162219 12217908.779758954 1.0 0.2668182123769115 1.6690181062290799 22.803494432699686 -6.764616098685231 1.5950596338239547 0.5765830087588847 1.6753517459052678 0.7095514377100938 0.3086174153961256 0.27522314684077115 1.3810154153541583 0.15258795904493996 0.36504646538095253 1.7194276301890128e-07 6.764616098685231 1.0987687371463832 TPVDRDTEDGLK(ub)AVITCYDTETR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPVDRDTEDGLKAVITCYDTETR 23 2 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 160994900.0 43340000.0 75781000.0 41873900.0 True False 56104484.35912143 71563720.7331473 34253279.86249694 1.0 1.275543685154866 0.6105265961138464 25.74161275240937 -6.7941704529228915 1.4795305220382442 1.153170944819067 0.6026084366514435 0.8145824182111203 0.11747534715266546 0.2291896724694141 0.9909555066658416 0.06248204857908129 0.14586036399742686 1.6063106806709818e-07 6.7941704529228915 -0.5505625081676235 TPVEEVPAAIAPFQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPVEEVPAAIAPFQGR 16 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 11885800.0 1691800.0 5693400.0 4500600.0 False True 2217966.1834145053 4843966.912699377 4034921.0848036404 1.0 2.1839678841460994 1.8191986491840813 21.08080593870472 -10.061770348763655 4.4919715594466165 0.9999420580899553 2.001583266434966 0.9095231811931297 0.14891641682234774 11451952.136938136 12825877.487635365 5546.091004711755 0.050978050545426146 8.674204390720634e-11 10.061770348763655 1.0016412083450108 TPVEEVPAAIAPFQGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPVEEVPAAIAPFQGR 16 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 12645300.0 3613400.0 2846700.0 6185200.0 False True 3498694.59487516 3983402.1553443847 4565110.567977394 1.0 1.1385395459149872 1.3048039616445246 21.738385304868203 -6.968698422566733 0.28757892834186055 0.9665578112247878 1.4819053088558567 0.9999703736898655 0.0006782129417503502 0.07672730604773757 0.010534313160922407 0.002943107386567379 0.015120342548205047 1.0747354578611793e-07 6.968698422566733 0.5153474976310689 TPVEEVPAAIAPFQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPVEEVPAAIAPFQGR 16 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 12687200.0 1691800.0 5793600.0 5201800.0 False True 2317304.1791759226 5537619.5951268235 3973241.9744338477 1.0 2.3896817883857207 1.7145966464561455 21.144016000227612 -10.669907440270274 7.0378086026561215 0.9950003212181304 2.052139217420311 0.7640775022047677 0.27560235511030406 0.02158135877164335 0.0010122243921110534 0.2663668348891741 0.08895027762647903 2.1384177947682322e-11 10.669907440270274 1.0571388962021806 TPVEPEVAIHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPVEPEVAIHR 11 0 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 0 48243200.0 8483000.0 22352200.0 17408000.0 False True 11121295.149488864 19017338.888193168 15606787.149327159 1.0 1.7099931826795556 1.4033246073902146 23.40682147358056 -10.111063670851758 4.567500618428347 0.9999627814534269 1.5566588949326892 0.8145804600980585 0.12519692182081438 87243340.22325635 4.16776632494389 44462.04662773048 0.04285823634756853 7.743482641752339e-11 10.111063670851758 0.5566961134792623 TPVEPEVAIHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPVEPEVAIHR 11 0 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 0 27579700.0 3064700.0 2462000.0 22053000.0 False True 2967412.7760319626 3445089.43916039 16276657.724181183 1.0 1.1609741209536675 5.485134341824328 21.500774193315856 -6.914772517326751 0.862597592720933 0.8854656681818779 6.105003025588992 0.9926014961183528 0.17868753036881815 0.10134607352255483 0.12227272527748592 0.1498378911780903 0.4286680011492624 1.2168232035676823e-07 6.914772517326751 5.219537357407114 up TPVEPEVAIHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPVEPEVAIHR 11 0 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 0 36033000.0 22841000.0 0.0 13192000.0 False True 34651466.90077431 0.0 10584595.417741003 1.0 0.0 0.30545879769102885 25.046413091485352 -10.371993480994428 5.791680389250046 1.000195348057454 0.15272939884555575 0.9111770788516189 0.12470303196451583 0.000314622285114534 3.411545627362771e-05 0.1207702010071603 0.04024773050167749 4.246259377737367e-11 10.371993480994428 -0.8474659492118981 TPVEPEVAIHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPVEPEVAIHR 11 0 P60866;P60866-2;E5RJX2;E5RIP1 P60866 RPS20 40S ribosomal protein S20 0 54112700.0 22841000.0 18959700.0 12312000.0 False True 29568124.76342158 17904576.028084233 10071342.331788123 1.0 0.6055364069024018 0.3406148483331373 24.8175394135778 -8.249861559232013 0.19430145236118104 1.2916618514695493 1.6188980517198777e-07 0.9997997913476872 0.0038333663424752157 0.08837238200529092 0.04154847688206703 0.11257975244087855 0.11775859327253843 5.6252061223596815e-09 8.249861559232013 -1.2916616895797441 down TPVIVTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPVIVTLK 8 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 36282900.0 9931900.0 10837000.0 15514000.0 False True 13020817.080656407 9220161.84229515 13908760.100796273 1.0 0.7081093133542693 1.0681941090670097 23.63431664737133 -6.691095295743944 1.8627015912435732 0.8171866185228849 1.0669592487354995 0.3754396217247613 0.12342262140349397 0.4143393917224187 2.7881763356713347 0.05299243084325818 0.13779671761507378 2.036595145607371e-07 6.691095295743944 0.24977263021261464 TPVIVTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPVIVTLK 8 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 26765600.0 9588400.0 5519200.0 11658000.0 False True 9284021.490424795 7723045.342247772 8604420.067496665 1.0 0.8318642250250112 0.9267988098014371 23.14631843152546 -10.108426449048574 4.587340038383538 1.0000098094027632 0.8793315174156321 0.6829581603137456 0.038756881951355515 3.888560213015812e-06 7.557634476681915e-07 0.03752923974403139 0.012508729860899598 7.790647437022455e-11 10.108426449048574 -0.12067829198713109 TPVIVTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPVIVTLK 8 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 52635900.0 9931900.0 17057000.0 25647000.0 False True 13603991.829505455 16303365.340043887 19589706.81654521 1.0 1.1984251052462271 1.4399969554566656 23.697526708894223 -6.968493215276796 0.2919406796091906 0.9538808176380218 1.6920250974436284 0.9999681273721537 0.001015712708283397 0.07679470973262743 0.010771078465052993 0.0041769087228629535 0.021858094628588468 1.0752433981466766e-07 6.968493215276796 0.7381442798056066 TPVLFDIYEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPVLFDIYEIK 11 0 P50995-2;P50995 P50995-2 ANXA11 Annexin A11 0 17358000.0 6611600.0 5894100.0 4852300.0 False True 6401718.377006867 8247644.867325452 3581337.0641202712 1.0 1.2883485935508538 0.5594337103274342 22.610027780879285 -6.799387170911936 1.458523890376278 1.1592167785144774 0.5495350745208725 0.8303433246695823 0.12345835175856607 0.22162857708608405 0.9308755820915708 0.06659455592760047 0.15492493066785176 1.5871311998202738e-07 6.799387170911936 -0.6096817039936049 TPVPSDIDISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPVPSDIDISR 11 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 11828400.0 1333900.0 3952200.0 6542300.0 False True 1748755.817505973 3362547.165554942 5865365.5541729685 1.0 1.9228225758531077 3.354022039816851 20.737897426069775 -6.964696741943284 0.36321891502840054 0.8811209047607 4.4450156469517195 0.9999067576478048 0.009351715979660462 0.07806401481036591 0.015223684958906194 0.019081825311613242 0.12201124412972252 1.084684060094278e-07 6.964696741943284 3.563894742191019 TPVPSDIDISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPVPSDIDISR 11 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 16528200.0 1333900.0 5673700.0 9520600.0 False True 1827078.8772920908 5423017.173583103 7272030.362911854 1.0 2.968135224474022 3.980140350420838 20.801107487592667 -8.886664370848447 0.26179792331163015 1.3360986091659192e-16 4.629668680647723 0.9990681899932818 0.03777030069600354 0.3873924716450783 0.08525701942278416 0.760820603454895 0.39706204643974974 1.298182137633766e-09 8.886664370848447 4.629668680647723 TPVQIK(ub)EFGAVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPVQIKEFGAVSK 13 1 Q8TED0;D6RF65 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 1 21559900.0 6918500.0 12009000.0 2632400.0 True False 6698876.004495439 16804256.32610769 1942895.4696927632 1.0 2.508518789544812 0.29003305455854644 22.675487617316314 -6.723607278643966 1.7463272747405922 1.914210899250684 0.29276738652822293 0.5294849592590751 0.6345257340834842 0.3483566841658023 2.0780779528228353 0.28829125836313174 0.7206686937861184 1.889699383377016e-07 6.723607278643966 -1.6214435127224611 TPVQIK(ub)EFGAVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPVQIKEFGAVSK 13 1 Q8TED0;D6RF65 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 1 11632130.0 3857800.0 6775900.0 998430.0 True False 5284132.913125001 6476518.333095117 762621.3973113117 1.0 1.2256539416350425 0.14432290213917093 22.33323532483675 -6.852234517478579 1.2241724805858123 1.1206933930850964 0.09917497641492032 0.9435041881252254 0.11070545625699456 0.15501719773355987 0.4459036058310464 0.07071859921615073 0.16390678182783355 1.405288468420178e-07 6.852234517478579 -1.021518416670176 down TPVQIK(ub)EFGAVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPVQIKEFGAVSK 13 1 Q8TED0;D6RF65 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 1 18808500.0 6918500.0 9943200.0 1946800.0 True False 5753039.291517681 9889634.008029325 2353866.8790138275 1.0 1.7190277185505523 0.40915188646188877 22.45589289275059 -6.757698816466395 1.6214574114427032 1.418850634111826 0.40495437330132666 0.6813820098289624 0.3023302969260849 0.2867972648539833 1.4856251401744067 0.14716325193033541 0.3544189673228062 1.7470333017490995e-07 6.757698816466395 -1.0138962608104993 TPVTDPATGAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPVTDPATGAVK 12 0 P49748-2;P49748;P49748-3 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 5008580.0 1233900.0 686180.0 3088500.0 False True 1194730.519902713 960175.2523814281 2279529.196986059 1.0 0.8036751689072238 1.907986076367817 20.188253813938168 -6.860962032049202 1.1809544214851126 0.8932096249519074 1.9624306740449775 0.954794340984675 0.10227419275153118 0.14580846387442722 0.3858762194992319 0.06752259103451319 0.15778294656980618 1.3773298759202914e-07 6.860962032049202 1.0692210490930703 TPWLYEQEGEVEK(ub)PFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPWLYEQEGEVEKPFIK 17 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 31775800.0 11583000.0 16081000.0 4111800.0 True False 15185425.169931551 13681777.483247057 3686350.379170689 1.0 0.9009808635676632 0.24275582263379625 23.856183966655973 -6.933707161385173 0.7157090769577112 1.0087648311714137 0.09391698749677894 0.9972179769811877 0.017725940997840348 0.09075815982957802 0.06858191408499334 0.016521301042520847 0.05839163765855759 1.1649112477965367e-07 6.933707161385173 -0.9148478436746348 down TPWLYEQEGEVEK(ub)PFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPWLYEQEGEVEKPFIK 17 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 28905000.0 11583000.0 13067000.0 4255000.0 True False 15865548.118805233 12489656.733209431 3250056.63447576 1.0 0.7872187358220293 0.20484994342070723 23.919394028178864 -7.027011560789821 0.5472600498802223 1.0070817919711017 4.874759908778018e-12 0.9993680894819686 0.008448922551289866 0.0745959786044245 0.0328328941909118 0.009404769458743707 0.043171674305365 9.396982957428072e-08 7.027011560789821 -1.007081791966227 down TPWLYEQEGEVEK(ub)PFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPWLYEQEGEVEKPFIK 17 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 48484800.0 21586000.0 24767000.0 2131800.0 True False 17949715.421941273 24633575.25513538 2577549.52367047 1.0 1.3723657827479496 0.1435983503404037 24.09745763569114 -6.825421666709341 1.3483299092090775 1.1996741643696465 0.11353859542533606 0.8963938577290047 0.16559139633030417 0.18652371435525278 0.664789074233165 0.0964723756739732 0.22208987545978218 1.4947836307824073e-07 6.825421666709341 -1.0861355689443104 down TPWLYEQEGEVEKPFIK(ub)TGFSVSVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPWLYEQEGEVEKPFIKTGFSVSVEK 26 2 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 38434000.0 14768000.0 13135000.0 10531000.0 True False 22404135.6854181 10790956.625776585 8449543.234098727 1.0 0.4816502085728735 0.37714212022015986 24.417261734981658 -13.999999999999998 0.22511921730452258 4.199999987819976 0.323910724167473 0.9995035309038893 0.006068340439364345 13.143975279435919 0.15026743698231274 18.749631310429212 0.05594545867610448 1.0000000000000041e-14 13.999999999999998 -3.876089263652503 TPYHVNLLLAGYDEHEGPALYYMDYLAALAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TPYHVNLLLAGYDEHEGPALYYMDYLAALAK 31 0 P49721 P49721 PSMB2 Proteasome subunit beta type-2 0 42460000.0 13445000.0 13451000.0 15564000.0 False True 20397047.961162418 11050563.956857312 12487768.578056464 1.0 0.5417727103401656 0.6122341135753643 24.28185703209612 -10.651769724008542 6.6271895340332145 1.0020823264889673 0.5770034119577958 0.9796133980054486 0.028765747414454767 0.0008884837778551824 4.668595144371906e-05 0.027961153668744597 0.009284105056449369 2.2296170458956806e-11 10.651769724008542 -0.4250789145311715 TPYIVLSGSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPYIVLSGSGK 11 0 O43290 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 0 13576900.0 5967700.0 7609200.0 0.0 False True 7823712.491289001 6473937.020429288 0.0 1.0 0.8274763454865492 0.0 22.89942192389182 -7.209519950307002 0.8846077907851786 0.9903745642608854 1.3570610673936862e-15 0.9892537040683138 0.04524541157696263 0.09386061035819668 0.13998636451835844 0.0381648423121907 0.06703004791086198 6.172769352142702e-08 7.209519950307002 -0.9903745642608841 down TPYIVLSGSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPYIVLSGSGK 11 0 O43290 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 0 9564400.0 5967700.0 3596700.0 0.0 False True 8174119.961028573 3437785.9013036177 0.0 1.0 0.4205695435953733 0.0 22.96263198541471 -8.200681364859081 0.5477195283189297 1.0266295239531658 9.648048738388978e-20 0.9912227721342342 0.03840803739355634 0.12887465673037563 0.17307688986356523 0.05387010809651205 0.07300542840120333 6.2996821127314335e-09 8.200681364859081 -1.0266295239531658 TPYTDVNIVTIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPYTDVNIVTIR 12 0 P50213-2;P50213;H0YLI6;H0YMU3;H0YL72;H0YKD0 P50213-2 IDH3A Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0 15962400.0 5096400.0 5281400.0 5584600.0 False True 6681429.753607809 4493435.706735959 5006759.16326587 1.0 0.6725260718799916 0.7493544567406912 22.671725426174156 -10.596543551621359 6.314087814723969 1.0008194607498169 0.7109402643103424 0.9496837254940153 0.031365056778480366 0.000362789271997748 2.318139240652631e-05 0.03045085323800984 0.010123028546325373 2.5319577145023904e-11 10.596543551621359 -0.28987919643947446 TPYTDVNIVTIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TPYTDVNIVTIR 12 0 P50213-2;P50213;H0YLI6;H0YMU3;H0YL72;H0YKD0 P50213-2 IDH3A Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0 11952900.0 3314700.0 2839100.0 5799100.0 False True 3209476.6628750484 3972767.4357109135 4280141.7407291075 1.0 1.2378240607464364 1.3335949097990816 21.61390664005868 -13.51904570440991 0.13004643174474906 6.4917947624790976e-15 1.4707767249920911 0.9996545415574062 0.002606658765309026 10.124976235601126 0.10794176418225694 2.6582795075438663 0.11869865922767736 3.026594897660339e-14 13.51904570440991 1.4707767249920847 TPYTDVNIVTIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPYTDVNIVTIR 12 0 P50213-2;P50213;H0YLI6;H0YMU3;H0YL72;H0YKD0 P50213-2 IDH3A Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0 17349600.0 5096400.0 5415400.0 6837800.0 False True 6980676.805031432 5176129.721666984 5222852.468911487 1.0 0.7414939648740374 0.7481871192127151 22.734935487697047 -10.180710005042881 5.243719576086238 1.0000129028214002 0.7448405420432668 0.9994842045878363 0.0027324688169585343 4.1219537029119186e-07 6.440854407304408e-08 0.002645835260709677 0.0008819005184541594 6.596141977328376e-11 10.180710005042881 -0.25517236077813343 TPYTDVNIVTIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TPYTDVNIVTIR 12 0 P50213-2;P50213;H0YLI6;H0YMU3;H0YL72;H0YKD0 P50213-2 IDH3A Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0 9627100.0 3314700.0 3329000.0 2983400.0 False True 2756319.9161080653 3311066.016245236 3607215.1463169507 1.0 1.2012633210300474 1.3087069919700587 21.394311915492956 -13.475344102505963 0.08149121073052608 1.0313205988818546e-16 1.628788997467282 0.9998913365579833 0.001333807202734497 10.296289330650307 0.07599937566593683 1.9406885126696747 0.27804708878105505 3.347001426799605e-14 13.475344102505963 1.628788997467282 TPYTDVNIVTIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TPYTDVNIVTIR 12 0 P50213-2;P50213;H0YLI6;H0YMU3;H0YL72;H0YKD0 P50213-2 IDH3A Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0 16136400.0 4972900.0 6119400.0 5044100.0 False True 6437517.080513947 5778850.010615069 4126125.5568366176 1.0 0.8976830567343067 0.6409498421877902 22.61807292438158 -6.955382977253421 0.4962443653511606 1.0053132404491336 0.5223170273585215 0.9995587961480012 0.003172413089725567 0.08139354568402508 0.027554007281878082 0.0037472350403039223 0.021175977764510807 1.1081971342194922e-07 6.955382977253421 -0.48299621309061214 TPYTIMFGPDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TPYTIMFGPDK 11 0 P27824;P27824-2;P27824-3;H0Y9Q7;D6RFL1;H0Y9H1;D6RGY2 P27824 CANX Calnexin 0 13394000.0 3735400.0 4461100.0 5197500.0 False True 4897145.573665057 3795521.2692316 4659712.557940476 1.0 0.7750476705537275 0.9515160388530405 22.223509651889763 -9.898166949152921 5.342364694608716 1.0000001775955618 0.863281854803092 0.44453957619650053 0.07204290968317882 1.524264691912339e-07 3.132495588635656e-08 0.06975533778260407 0.02325174911735652 1.2642502577510588e-10 9.898166949152921 -0.13671832279246976 TPYTIMFGPDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TPYTIMFGPDK 11 0 P27824;P27824-2;P27824-3;H0Y9Q7;D6RFL1;H0Y9H1;D6RGY2 P27824 CANX Calnexin 0 9441100.0 3735400.0 3081200.0 2624500.0 False True 5116478.325389374 2945062.395834158 2004647.1532741806 1.0 0.575603414798016 0.3918021392422537 22.286719713412655 -13.999999999998728 0.11398500405077631 3.0352732835003753 0.0731757821848626 0.9997228913337594 0.00423970310441961 11.99073720742549 0.1030790615390859 5.57748368575295 0.2827955499847591 1.0000000000029286e-14 13.999999999998728 -2.9620975013155126 TQAIVCQQLDLTHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQAIVCQQLDLTHLK 15 0 P61221;D6R9I9;D6RGF4 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 47176000.0 10811000.0 20546000.0 15819000.0 False True 14173325.693872938 17480616.88768074 14182201.626562865 1.0 1.2333461648480657 1.00062624206073 23.756674982743128 -10.826774392071519 2.7913113049461242 0.9616009091249421 1.1169862032120286 0.25201818841060586 0.09500751209223396 913430242.6669654 488470003.6493885 233031393.19367126 0.03476916834716915 1.4901349741626028e-11 10.826774392071519 0.15538529408708646 TQAIVCQQLDLTHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQAIVCQQLDLTHLK 15 0 P61221;D6R9I9;D6RGF4 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 26951000.0 14012000.0 5127200.0 7811800.0 False True 13567196.729781022 7174517.697994787 5765655.231023371 1.0 0.5288135670831823 0.4249702680559885 23.693619324406054 -13.99999999999996 0.21252647707061045 3.753735685179938 0.3652839258051206 0.9994915801335956 0.005641843581329808 12.806980183900645 0.1461007985115148 14.744506460959128 0.06044050353686683 1.000000000000094e-14 13.99999999999996 -3.388451759374817 TQAIVCQQLDLTHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQAIVCQQLDLTHLK 15 0 P61221;D6R9I9;D6RGF4 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 108088000.0 21959000.0 60698000.0 25431000.0 False True 33313408.417937186 49865967.66436147 20404551.70319673 1.0 1.496873782435056 0.6125026730140936 24.98959963323709 -6.754294322013149 1.6343592514773455 1.2906571070693302 0.6101959378724644 0.6670860541073305 0.20884749269876318 0.2926086775440079 1.5390817622691948 0.10090059644387753 0.24382604565534058 1.7607823571653913e-07 6.754294322013149 -0.6804611691968658 TQAIVCQQLDLTHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQAIVCQQLDLTHLK 15 0 P61221;D6R9I9;D6RGF4 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 43617000.0 10811000.0 13613000.0 19193000.0 False True 14808118.856289702 13011532.647828888 14660008.692242837 1.0 0.8786755950640065 0.9899980432704351 23.81988504426602 -10.40153956154053 5.609305336752979 1.0000288650872147 0.9343368192044863 0.3168895883858752 0.0454471991705273 1.6412819824411118e-05 1.751078961942162e-06 0.04402339955680985 0.014668020459935196 3.9669839051649365e-11 10.40153956154053 -0.06569204588272837 TQAIVCQQLDLTHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQAIVCQQLDLTHLK 15 0 P61221;D6R9I9;D6RGF4 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 30033500.0 14012000.0 9223400.0 6798100.0 False True 11651598.836849848 9173711.713498436 8219551.279136995 1.0 0.787335012297648 0.7054440677395697 23.47402459984033 -13.999999999999998 0.13214309241815123 2.0111025040157435 0.593822700663579 0.999636022681896 0.0023683514350781513 11.934044713166607 0.11325123242246238 3.128279069361131 0.09935449676414355 1.0000000000000041e-14 13.999999999999998 -1.4172798033521645 TQAIVCQQLDLTHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQAIVCQQLDLTHLK 15 0 P61221;D6R9I9;D6RGF4 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 60746000.0 21959000.0 21896000.0 16891000.0 False True 28426358.37660237 20677468.351869073 13817011.31629574 1.0 0.7274047585669159 0.4860633618011539 24.76072595532954 -6.972561029794542 0.18716130284130728 1.1697609881232356 0.03713335489489148 0.9999960788686546 0.00041568588921320085 0.07548013099190187 0.005951007180970591 0.008730335414980063 0.02651936680606701 1.0652191618469617e-07 6.972561029794542 -1.132627633228344 down TQAIVCQQLDLTHLK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQAIVCQQLDLTHLKER 17 1 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 54577200.0 10590300.0 13454000.0 30532900.0 True False 13883985.856611088 11446715.64328124 27373648.400257986 1.0 0.8244545738881388 1.9715986952855886 23.72691846484168 -6.867871404940488 1.145362814655932 0.90189669697705 2.0360995432715083 0.9625086754125655 0.09768635810913472 0.13890859040269 0.3419235629121308 0.06627513225403066 0.15634744867698316 1.355590744796658e-07 6.867871404940488 1.1342028462944582 TQAIVCQQLDLTHLK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQAIVCQQLDLTHLKER 17 1 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 31438700.0 10755900.0 9899800.0 10783000.0 True False 10414459.841982001 13852841.766774975 7958608.816934005 1.0 1.3301546097410086 0.7641883436769182 23.312084678481817 -6.748621455654069 1.6553959849418645 1.1944602868589003 0.7632111513681099 0.6428373803779228 0.13872346747344066 0.30245352030632944 1.6303596003124208 0.06621746857808088 0.16096316407702327 1.7839330205343593e-07 6.748621455654069 -0.43124913549079036 TQAIVCQQLDLTHLK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQAIVCQQLDLTHLKER 17 1 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 301429300.0 35369300.0 69026000.0 197034000.0 True False 53657813.94218976 56707770.99740047 158090143.53692994 1.0 1.0568408742573205 2.9462650809303232 25.67728494357692 -6.913321915686846 0.8727956629909513 0.9474650085628555 3.2086307999895998 0.992116198207282 0.08030045845600227 0.10226240642936674 0.12715076276476936 0.06684250241245492 0.18905494311344873 1.220894351074904e-07 6.913321915686846 2.2611657914267442 up TQAIVCQQLDLTHLK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQAIVCQQLDLTHLKER 17 1 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 46773100.0 10590300.0 13063500.0 23119300.0 True False 14505820.10209645 12486311.374782387 17658997.496929612 1.0 0.8607794172890512 1.2173732593290227 23.790128526364573 -6.800868750905151 1.452831849004646 0.9232699988419768 1.2223752547243383 0.8345525634494678 0.05968668255569951 0.21952859811835262 0.9147750739743649 0.0323216522142771 0.07511304287270239 1.581725983950454e-07 6.800868750905151 0.2991052558823615 TQAIVCQQLDLTHLK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQAIVCQQLDLTHLKER 17 1 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 35569800.0 10755900.0 4430500.0 20383400.0 True False 8944007.41716196 4406632.017114609 24645474.697806887 1.0 0.4926910065681593 2.7555293224060393 23.092489953916093 -6.847840025260746 1.2454681826519074 0.7297037130304083 2.842290413596981 0.9371053953025658 0.2431433982655547 0.15984676688937285 0.4782338906701051 0.15284351545230337 0.35323569955390055 1.4195803355456287e-07 6.847840025260746 2.1125867005665726 up TQAIVCQQLDLTHLK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQAIVCQQLDLTHLKER 17 1 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 212895000.0 35369300.0 46188700.0 131337000.0 True False 45786256.083135 43618258.24186956 107435013.63142109 1.0 0.9526495934210265 2.3464467904156487 25.44841126566937 -6.89903644557592 0.9673519716235229 0.9405089862853263 2.489913326619668 0.9860804305530224 0.076236035720572 0.1121175789139361 0.18145252018282898 0.059213473543170254 0.15332981053404737 1.2617216476785772e-07 6.89903644557592 1.5494043403343416 up TQANDYFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQANDYFK 8 0 P53041;H0YDU8 P53041 PPP5C Serine/threonine-protein phosphatase 5;Serine/threonine-protein phosphatase 0 9985000.0 1556600.0 6968300.0 1460100.0 False True 2361476.002703264 5724752.421423603 1171510.5950154352 1.0 2.424226379971797 0.496092525892436 21.171257444233824 -6.708806294188985 1.7993852072843795 1.8766280339742607 0.5007592374886435 0.45951567987869857 0.6002711915486558 0.37745343642187207 2.3815393155211493 0.26554573898038936 0.6756081555866825 1.9552113327220185e-07 6.708806294188985 -1.375868796485617 TQAPTK(ub)ASE ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQAPTKASE 9 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 4053700.0 1229900.0 1686900.0 1136900.0 True False 1612410.810368542 1435221.0954846991 1019264.4939148696 1.0 0.8901088272638513 0.6321369761108836 20.620787930171577 -6.956795938559185 0.4784597956651485 1.0062827014275553 0.5052355894331464 0.999632276439487 0.0029566064686256796 0.0808662115996352 0.0255162037528257 0.0036260406522393837 0.021281726304333344 1.104597513929804e-07 6.956795938559185 -0.5010471119944089 TQAPTK(ub)ASE ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQAPTKASE 9 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 4471430.0 1410300.0 2085200.0 975930.0 True False 1365530.7984591906 2917831.234174345 720304.6557275724 1.0 2.136774386536508 0.5274905967264414 20.38103042263152 -6.716932652232383 1.7705263990228917 1.6938569520196323 0.5304464260605907 0.49795272070769747 0.47854669530464866 0.36129674996681854 2.2117604328397573 0.21475987791099696 0.5410469467677066 1.918966299312092e-07 6.716932652232383 -1.1634105259590415 TQAPTK(ub)ASE ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQAPTKASE 9 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 3568520.0 1229900.0 1672200.0 666420.0 True False 1684627.2667977696 1598316.6747740733 509025.32135072595 1.0 0.9487657633680832 0.30215901842685283 20.68399799169447 -6.922680243125477 0.8046075700555291 1.0129365042678853 0.19118015130917185 0.9948933861341301 0.02269437083409429 0.09662054117234362 0.0976328492380899 0.019836266771644878 0.06102998465187052 1.194867522700461e-07 6.922680243125477 -0.8217563529587134 down TQAPTK(ub)ASE ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQAPTKASE 9 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 3368750.0 1410300.0 1422300.0 536150.0 True False 1172726.936883339 1414637.7875955545 648256.4861224901 1.0 1.2062806294491046 0.5527770069350575 20.161435698065798 -6.821838178369831 1.3639149860413433 1.110981052952458 0.5379410783907385 0.8885599441453664 0.09105753971460037 0.19110078401962333 0.6980293923638424 0.05245669362041793 0.12084826398602254 1.5071685447421948e-07 6.821838178369831 -0.5730399745617195 TQCPTCCVTVTEPDLK(ub)NNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQCPTCCVTVTEPDLKNNR 19 1 Q9NS91;F8WE49;C9J0Q4;F8WFA6 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 7300600.0 1463900.0 2869400.0 2967300.0 True False 1919187.0764277673 2441296.704833596 2660272.2603514707 1.0 1.272047282319994 1.3861453596817173 20.87206391716802 -12.973468344632812 0.12972909433130989 9.269976223827858e-17 1.5551676307210525 0.9996705860007841 0.002939884997790614 8.287241407693003 0.10236869025545135 2.2643558778022825 0.14089468605435096 1.0629960613596407e-13 12.973468344632812 1.5551676307210525 TQCPTCCVTVTEPDLK(ub)NNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQCPTCCVTVTEPDLKNNR 19 1 Q9NS91;F8WE49;C9J0Q4;F8WFA6 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 5896200.0 1463900.0 1588900.0 2843400.0 True False 2005143.3904099986 1518697.1442103365 2171847.481661193 1.0 0.7574007681813735 1.0831382394139444 20.935273978690912 -6.7073103559454665 1.8049527530302965 0.8504465969879792 1.0823089371067098 0.4522657730136036 0.10227401564086751 0.38049712740396857 2.414720756925458 0.045122487481197855 0.11500087389763604 1.9619577196116712e-07 6.7073103559454665 0.23186234011873064 TQCPTCCVTVTEPDLK(ub)NNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQCPTCCVTVTEPDLKNNR 19 1 Q9NS91;F8WE49;C9J0Q4;F8WFA6 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 44111900.0 3293600.0 3140300.0 37678000.0 True False 4263630.126562117 2965539.5444544433 30820990.608927276 1.0 0.695543341337078 7.228814342246684 22.02365085786224 -6.89596741931896 0.9863705843248917 0.697508666502459 7.861184405495865 0.9844522377321654 0.37539611457965305 0.11443622225827217 0.19461424211401507 0.2874545714423002 0.7338973316437228 1.2706694269871725e-07 6.89596741931896 7.1636757389934065 up TQCSEEDQCK(ub)INK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQCSEEDQCKINK 13 1 Q9UK73;H3BT12 Q9UK73 FEM1B Protein fem-1 homolog B 1 7864600.0 1050000.0 1973900.0 4840700.0 True False 1592926.7652823003 1621642.1228489068 3883933.52324582 1.0 1.018026790805739 2.4382373426674797 20.60324850988937 -6.90966893062447 0.8979864886243941 0.9555657192331447 2.620481866059637 0.9907960305613243 0.06464091827101714 0.10463735732675394 0.1399578064931869 0.052835905779102965 0.14551861353724596 1.2312069812140777e-07 6.90966893062447 1.6649161468264926 up TQCYDPSTNK(ub)WSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQCYDPSTNKWSLK 14 1 A0A0C4DGF2;Q8WZ60 A0A0C4DGF2 KLHL6 Kelch-like protein 6 1 21224000.0 3957900.0 8000000.0 9266100.0 True False 5188845.22835812 6806431.183755759 8307332.858707509 1.0 1.3117429570951924 1.6009983904137677 22.306982073477908 -6.9720248957488815 0.20410874348693842 0.8366973614546593 2.0840661784087375 0.999994165781072 0.0005927475372510247 0.07565097479855687 0.0066240728772619046 0.009081182828571694 0.030396232061454545 1.0665349808077496e-07 6.9720248957488815 1.2473688169540782 TQCYDPSTNK(ub)WSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQCYDPSTNKWSLK 14 1 A0A0C4DGF2;Q8WZ60 A0A0C4DGF2 KLHL6 Kelch-like protein 6 1 10327100.0 4819200.0 2036900.0 3471000.0 True False 4666217.133896707 2850244.792293172 2561840.972232028 1.0 0.6108255810875572 0.5490188087524043 22.153822011388556 -13.999999999999998 0.25898273066268124 3.8338963146945515 0.5262077596100011 0.9995602644689173 0.0041861625920064215 14.372349180262898 0.16103870144032553 21.302986198898456 0.027166578268182286 1.0000000000000041e-14 13.999999999999998 -3.3076885550845505 TQCYDPSTNK(ub)WSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQCYDPSTNKWSLK 14 1 A0A0C4DGF2;Q8WZ60 A0A0C4DGF2 KLHL6 Kelch-like protein 6 1 64033000.0 15281000.0 29585000.0 19167000.0 True False 23182394.190741748 24305325.601339936 15378634.04880545 1.0 1.0484389749116874 0.6633755738200305 24.46652623438428 -6.875350487085151 1.1053555515869333 1.028519613656451 0.6384024501686042 0.9697397272508177 0.029789595392762817 0.1318305921483473 0.29782649195716854 0.020839319522749068 0.049852533202057646 1.3324456793846718e-07 6.875350487085151 -0.39011716348784675 TQCYDPSTNK(ub)WSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQCYDPSTNKWSLK 14 1 A0A0C4DGF2;Q8WZ60 A0A0C4DGF2 KLHL6 Kelch-like protein 6 1 25979300.0 3957900.0 7370400.0 14651000.0 True False 5421242.588225783 7044751.357346507 11190735.54681653 1.0 1.2994717064768082 2.0642381086434534 22.3701921350008 -6.955004622661128 0.5009013996522681 0.9848030442959721 2.4119422207858894 0.9995377356055636 0.009634328167313628 0.08153627008208554 0.02811135293793626 0.01127951943316557 0.06308827698923289 1.1091630091901892e-07 6.955004622661128 1.4271391764899173 up TQCYDPSTNK(ub)WSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQCYDPSTNKWSLK 14 1 A0A0C4DGF2;Q8WZ60 A0A0C4DGF2 KLHL6 Kelch-like protein 6 1 16453500.0 4819200.0 2516200.0 9118100.0 True False 4007378.3267589738 2502644.7311734026 11024652.552668964 1.0 0.6245092245127386 2.7510885306367654 21.934227286822832 -6.861301962857846 1.1792351533636125 0.7955507655192183 2.856611652156281 0.9551982060902026 0.19615807490619813 0.14546079568265521 0.38364239170255565 0.12967635850498266 0.3031411130833972 1.3762522346138547e-07 6.861301962857846 2.0610608866370628 up TQCYDPSTNK(ub)WSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQCYDPSTNKWSLK 14 1 A0A0C4DGF2;Q8WZ60 A0A0C4DGF2 KLHL6 Kelch-like protein 6 1 65208000.0 15281000.0 36514000.0 13413000.0 True False 19781555.733542543 34481963.80161432 10971971.629002105 1.0 1.7431371053968758 0.5546566598094967 24.23765255647673 -6.737653469805161 1.6954567855644191 1.4433614185079622 0.554331920148729 0.5943121667359932 0.31225539118471934 0.3220668636422571 1.8169278455828164 0.14575871324020645 0.35858086302019493 1.8295594673056383e-07 6.737653469805161 -0.8890294983592332 TQDDDTVNK(ub)LHPVYSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQDDDTVNKLHPVYSR 16 1 A0A087WZV0;O43314-2;O43314;H0Y9S9 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 1 28516900.0 6778500.0 9240400.0 12498000.0 True False 10283480.074729595 7591378.4244252695 10027764.821932012 1.0 0.7382110306296173 0.975133393468037 23.293825239728044 -10.350072534640754 7.544719227793536 1.0000017898232798 0.8566722121709971 0.32794054623242075 0.09672314960144388 2.9120381684962306e-06 2.5082084951376553e-07 0.09365295626795737 0.031217262299926732 4.4660899454563605e-11 10.350072534640754 -0.1433295776522827 TQDDDTVNK(ub)LHPVYSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQDDDTVNKLHPVYSR 16 1 A0A087WZV0;O43314-2;O43314;H0Y9S9 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 1 9183900.0 5994400.0 2102000.0 1087500.0 True False 8210691.672568957 2009126.6896155404 830654.8977655435 1.0 0.24469639949187447 0.10116746930598706 22.969072329762497 -13.999999999999991 0.23350103815353304 5.84656485635579 0.033667164028886 0.9995147700793937 0.008684779763522294 13.40286420059576 0.1529777659769903 30.175677560404832 0.0729153604489197 1.0000000000000205e-14 13.999999999999991 -5.812897692326904 TQDDDTVNK(ub)LHPVYSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQDDDTVNKLHPVYSR 16 1 A0A087WZV0;O43314-2;O43314;H0Y9S9 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 1 19341200.0 6778500.0 6032100.0 6530600.0 True False 8774901.874210991 5696408.332357939 5342097.809614639 1.0 0.6491706020211355 0.608792882951182 23.064951561820493 -13.999999999999998 0.3051365963318989 4.296499673653781 0.5993768407509974 0.9996612569425541 0.003233284439829897 16.930755576411077 0.17559021324580673 35.34012044332886 0.014277330150377266 1.0000000000000041e-14 13.999999999999998 -3.6971228329027834 TQDECILHFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQDECILHFLR 11 0 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 0 13625700.0 2521800.0 6674400.0 4429500.0 False True 3306104.221145938 5678605.536607431 3971177.830764276 1.0 1.7176123790311588 1.2011653490426912 21.656700773978727 -10.25032032221681 5.436210549829214 0.9999613843019469 1.4593888640369561 0.5133794841828951 0.2108386171080409 9.868452604414082e-05 1.3608951679578686e-05 0.20416072286298204 0.06804787106638782 5.619267124922843e-11 10.25032032221681 0.4594274797350092 TQDECILHFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQDECILHFLR 11 0 Q92922;Q8TAQ2;F8VXC8;Q8TAQ2-2;Q8TAQ2-3 Q92922;Q8TAQ2 SMARCC1;SMARCC2 SWI/SNF complex subunit SMARCC1;SWI/SNF complex subunit SMARCC2 0 18168700.0 2521800.0 8351000.0 7295900.0 False True 3454177.609082539 7982025.206935955 5572758.683777135 1.0 2.310832305191178 1.613338778273567 21.71991083550162 -10.243915571638986 5.476309788617136 0.9999303968228079 1.9620855417324026 0.7172583149359306 0.2847505399739274 0.00024201718837308788 3.341461833396171e-05 0.2757282560028981 0.09190284159518652 5.702751249773105e-11 10.243915571638986 0.9621551449095946 TQDLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQDLFR 6 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 3570030.0 991230.0 1417100.0 1161700.0 False True 1299512.1290849734 1205674.2038125372 1041498.4278132659 1.0 0.9277898811621633 0.8014534104784518 20.309538668689562 -6.962574886023297 0.3974937767133182 1.0071397952865662 0.7175091771650424 0.999854075812876 0.0009911898165446366 0.07879395812197036 0.01782521743586996 0.0016263053033295101 0.01059497690906447 1.0899965265083181e-07 6.962574886023297 -0.2896306181215238 TQDLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQDLFR 6 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 15712700.0 2276300.0 9880700.0 3555700.0 False True 3453313.5198210455 8117411.886738539 2852914.336481329 1.0 2.350615384368342 0.8261382350911395 21.71954988902317 -6.6728785615997985 1.9269442355012771 1.8599297562272277 0.8321806344744692 0.29198859872229554 0.5733303573984898 0.4545211272155683 3.2563282419427177 0.23928613737735327 0.6369747424487261 2.1238382514085248e-07 6.6728785615997985 -1.0277491217527586 TQDLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQDLFR 6 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 3513830.0 991230.0 1445600.0 1077000.0 False True 1357714.5179835367 1381728.6120400669 822634.7815112559 1.0 1.017687145374416 0.6058967261637773 20.372748730212454 -6.896865235640242 0.9808900751824344 1.0186242012341038 0.5653242402822558 0.9849406030174009 0.02332699752196564 0.11374906066699603 0.19072630768288967 0.017936398425035308 0.04597424756445866 1.2680452873896587e-07 6.896865235640242 -0.453299960951848 TQDLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQDLFR 6 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 2969590.0 1197900.0 1185500.0 586190.0 False True 996106.9259679154 1179113.4761966732 708759.6187636706 1.0 1.183721792769316 0.7115296563920284 19.92594108950511 -6.801192282206718 1.4509824524780286 1.1012173347847476 0.7048146524368264 0.8356217497285653 0.07879494975438311 0.21907299107498912 0.9104359858807965 0.0427178863794269 0.09927732702672873 1.5805481027586573e-07 6.801192282206718 -0.3964026823479212 TQDNSCSFGLHAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQDNSCSFGLHAR 13 0 Q9Y5Y6 Q9Y5Y6 ST14 Suppressor of tumorigenicity 14 protein 0 4351600.0 1506700.0 1442200.0 1402700.0 False True 1975298.2909035545 1227029.3816515699 1257562.0596485042 1.0 0.6211868796232763 0.6366441288587668 20.91363910125316 -9.916015062357722 6.874294818094873 1.0000000131171933 0.6289155042496657 0.9987003822231016 0.006310395575673012 1.2670806868138342e-09 2.1191133630581445e-10 0.006110014425228434 0.002036671414378694 1.213346768005376e-10 9.916015062357722 -0.37108450886752764 TQDNSCSFGLHAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQDNSCSFGLHAR 13 0 Q9Y5Y6 Q9Y5Y6 ST14 Suppressor of tumorigenicity 14 protein 0 10912200.0 2601100.0 5977200.0 2333900.0 False True 3946058.8658817085 4910521.959923247 1872603.6420152897 1.0 1.2444117350555637 0.4745503566117924 21.911981047150007 -6.821342275345527 1.366215611740655 1.1315607790449027 0.45727767522197765 0.8873986868751402 0.1077820227063793 0.19175169707204406 0.7029362639746378 0.061990725211113124 0.14281881768518168 1.5088905015046306e-07 6.821342275345527 -0.6742831038229251 down TQDNSCSFGLHAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQDNSCSFGLHAR 13 0 Q9Y5Y6 Q9Y5Y6 ST14 Suppressor of tumorigenicity 14 protein 0 4076500.0 1506700.0 1348500.0 1221300.0 False True 2063767.707036506 1288918.8111068276 932854.093463042 1.0 0.6245464577782678 0.4520150646230365 20.976849162776052 -13.999999999999762 0.1044032732431848 2.8326294839774127 0.10839584755761808 0.9997715038700253 0.0034580972929777447 12.048433064684465 0.0970873512979523 4.707715854761174 0.3057859152347113 1.0000000000005481e-14 13.999999999999762 -2.7242336364197945 TQDQISNIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQDQISNIK 9 0 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 0 6521210.0 1769710.0 2776000.0 1975500.0 False True 2320106.9478960205 2361831.620763248 1771094.210334088 1.0 1.0179839437596034 0.7633674869773557 21.14575987883349 -6.889947894598427 1.0227164495786574 1.013697990427844 0.7414925324862447 0.9808639977868834 0.016049528727019365 0.11918441106213327 0.22210729339580504 0.011958344543091469 0.029806041428091352 1.2884041214376128e-07 6.889947894598427 -0.27220545794159934 TQDQISNIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQDQISNIK 9 0 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 0 8881600.0 2081400.0 1762000.0 5038200.0 False True 2015327.096300758 2465575.7887086114 3718544.277239816 1.0 1.223412215929766 1.8451318816014557 20.942582582724167 -6.953126600308633 0.5233939709979399 0.9897057011417162 2.1067450099321725 0.9994243596703231 0.008578959232435164 0.08225401441819541 0.030950417050292302 0.009667185834070812 0.0513724527562202 1.1139697551793487e-07 6.953126600308633 1.1170393087904564 TQDQISNIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQDQISNIK 9 0 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 0 29969400.0 7932500.0 19511000.0 2525900.0 False True 12034182.44343032 16029109.609861193 2026654.7578587004 1.0 1.3319649826824569 0.16840817956562462 23.520634798140883 -6.830471735684093 1.3259552483613843 1.1773192585804217 0.13683003055733745 0.9067818474333148 0.1494218467580864 0.18023435092722292 0.6195937400266388 0.08847871139030558 0.2035955093644646 1.4775026357985891e-07 6.830471735684093 -1.0404892280230844 down TQDQISNIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQDQISNIK 9 0 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 0 6368110.0 1769710.0 2661200.0 1937200.0 False True 2424019.6116145086 2543619.3845884264 1479673.2578863564 1.0 1.04933944115009 0.6104213228294907 21.208969940356383 -6.8789711643019835 1.0854735404038656 1.0301861386080502 0.5799168635584685 0.9728481176702177 0.032348393331310996 0.1285475816943079 0.27779989053318804 0.02297660396933332 0.05542315165649288 1.3213833667007693e-07 6.8789711643019835 -0.4502692750495817 TQDQISNIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQDQISNIK 9 0 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 0 4308710.0 2081400.0 1242400.0 984910.0 False True 1730776.3216542446 1235706.9446029076 1190850.127290687 1.0 0.7139610873702278 0.6880439213268726 20.722987858158444 -13.999999999999998 0.3398247594699911 4.304805110326042 0.6839656258159473 0.9997348521598056 0.002301569984454706 19.687531753262178 0.1869802136627382 46.73457202908769 0.008012369563628411 1.0000000000000041e-14 13.999999999999998 -3.6208394845100944 TQDQISNIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQDQISNIK 9 0 Q14847;Q14847-2;C9J9W2;Q14847-3 Q14847 LASP1 LIM and SH3 domain protein 1 0 14831300.0 7932500.0 4300700.0 2598100.0 False True 10268777.622951774 4061362.2643808676 2125272.4587572073 1.0 0.3955059125346434 0.206964503156345 23.291761120233332 -13.99999999999756 0.16312046938427588 3.9975218187226793 0.02785557646181618 0.9995285108100744 0.007345221505824034 12.031936448948242 0.12773107000654657 11.409102781993276 0.16390503020148464 1.00000000000562e-14 13.99999999999756 -3.969666242260863 TQEAIIQIMK(ub)MR ddPTM_RPMI8226_Bortezomib_1h_R1 3 TQEAIIQIMKMR 12 1 Q93034 Q93034 CUL5 Cullin-5 1 282198700.0 85526000.0 88187500.0 108485200.0 True False 112125414.23496203 75030268.75218254 97260192.16751988 1.0 0.669163804335692 0.8674232584212207 26.740538074130807 -10.284833238867307 5.575658818665647 1.0000238458221087 0.7682935313784515 0.6455354236904762 0.08093908319873305 2.3994598394376934e-05 3.07757430098209e-06 0.07837698828302758 0.026122976773829968 5.1899928690028956e-11 10.284833238867307 -0.23173031444365721 TQEAIIQIMK(ub)MR ddPTM_RPMI8226_Bortezomib_2h_R1 3 TQEAIIQIMKMR 12 1 Q93034 Q93034 CUL5 Cullin-5 1 266604300.0 64161200.0 63874800.0 138568300.0 True False 62124437.82606525 89380340.74268165 102273105.2701063 1.0 1.4387307776197014 1.6462620644785306 25.888657555768273 -11.12467759640281 0.13821657906961707 9.47349592348386e-18 1.962499729137524 0.9997067166556983 0.004613686147239111 3.495775367646436 0.08346086865975484 1.3176028370076291 0.2207819562193955 7.50451108769963e-12 11.12467759640281 1.962499729137524 TQEAIIQIMK(ub)MR ddPTM_RPMI8226_Bortezomib_8h_R1 2 TQEAIIQIMKMR 12 1 Q93034 Q93034 CUL5 Cullin-5 1 404882000.0 103922000.0 131018000.0 169942000.0 True False 157657271.71587363 107636814.25169365 136352889.21177542 1.0 0.6827266074074546 0.8648690144626346 27.232216472897424 -10.188879306736457 5.255898542478663 1.0000123403730259 0.7737978118632577 0.6728190132109819 0.07435932630153935 104432011.74262057 3.9434657222286758 15596.447671574088 0.02545517523510538 6.473224858864319e-11 10.188879306736457 -0.2262145285097682 TQEAIIQIMK(ub)MR ddPTM_RPMI8226_Carfilzomib_1h_R1 3 TQEAIIQIMKMR 12 1 Q93034 Q93034 CUL5 Cullin-5 1 283009700.0 85526000.0 75458800.0 122024900.0 True False 117147273.4532449 72124780.70711762 93205131.80170174 1.0 0.6156761363797649 0.7956235689847379 26.8037481356537 -10.087442148246861 4.81932632090215 1.0000106439991996 0.7056498526810032 0.781066558259123 0.07346323174770673 102146353.97662137 6.757582112085945 13346.64828793473 0.02514841823261289 8.176319462838351e-11 10.087442148246861 -0.29436079131819637 TQEAIIQIMK(ub)MR ddPTM_RPMI8226_Carfilzomib_2h_R1 3 TQEAIIQIMKMR 12 1 Q93034 Q93034 CUL5 Cullin-5 1 315015200.0 64161200.0 84414200.0 166439800.0 True False 53352880.62310096 83959443.94969325 201241592.64931464 1.0 1.5736628082521964 3.7718974177034443 25.66906283120255 -6.945861608503089 0.6025681037758398 0.9753731742574279 4.483212834109981 0.9988351956104362 0.040772551901982736 0.08519131725289546 0.04317658966693865 0.04174132686927414 0.18489021280363926 1.1327612693942761e-07 6.945861608503089 3.507839659852553 TQEAIIQIMK(ub)MR ddPTM_RPMI8226_Carfilzomib_8h_R1 3 TQEAIIQIMKMR 12 1 Q93034 Q93034 CUL5 Cullin-5 1 491607400.0 112701300.0 139795000.0 239111100.0 True False 145894054.52474946 132015285.36031874 195595333.28707144 1.0 0.9048709064283608 1.3406669238456914 27.120345850837 -6.8495132213070296 1.2374077921950353 0.9492558801806591 1.3579285452581735 0.939600752984765 0.045979549986542856 0.1579904957564939 0.46575994735117504 0.029079568315647973 0.06727248331145656 1.4141216740478574e-07 6.8495132213070296 0.40867266507751443 TQEFLSACK(ub)SLQTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQEFLSACKSLQTR 14 1 Q13190-3;Q13190-2;Q13190-4;Q13190;E9PNU4;H0YEJ8;E9PP18;E9PRW9 Q13190-3 STX5 Syntaxin-5 1 8047900.0 2543800.0 2078600.0 3425500.0 True False 3484311.603610187 1986760.5789889903 2616467.4503870104 1.0 0.5702017514537033 0.7509280879689462 21.73244221992021 -10.199118272180126 5.4188278207416385 1.0000155208869768 0.660564919711277 0.8246651155047573 0.0737812179243126 1.3835408888723446e-05 2.0448111632518744e-06 0.07144162143486876 0.023812785690289273 6.322396489935547e-11 10.199118272180126 -0.3394506011756998 TQEFLSACK(ub)SLQTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQEFLSACKSLQTR 14 1 Q13190-3;Q13190-2;Q13190-4;Q13190;E9PNU4;H0YEJ8;E9PP18;E9PRW9 Q13190-3 STX5 Syntaxin-5 1 8395700.0 2036900.0 1691700.0 4667100.0 True False 1693772.599969985 1682586.4763238418 5642969.03176773 1.0 0.9933957346775232 3.3315977787500684 20.69180876576683 -6.906260753412099 0.9208039320220517 0.918767679564866 3.610814070603195 0.9894327655846793 0.11314724528997526 0.1069435420673116 0.15255696732123014 0.0909554790895269 0.24503185043937223 1.2409070347110223e-07 6.906260753412099 2.6920463910383288 up TQEFPQILTLIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQEFPQILTLIGR 13 0 Q9NZ08;Q9NZ08-2;H0Y9X5 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 4273400.0 785200.0 2055300.0 1432900.0 False True 1029404.8038876157 1748657.251496652 1284637.2533473598 1.0 1.698707102291277 1.2479417703277096 19.973378989571767 -10.211128112272148 3.9607963621613247 0.9996609792518315 1.4733244361936366 0.5951629130255833 0.18402417675195462 99693881.22797872 190429033.9016477 442767.4895009507 0.07274193772062973 6.149954288116548e-11 10.211128112272148 0.4736634569418051 TQEFPQILTLIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQEFPQILTLIGR 13 0 Q9NZ08;Q9NZ08-2;H0Y9X5 Q9NZ08 ERAP1 Endoplasmic reticulum aminopeptidase 1 0 5310600.0 785200.0 1596700.0 2928700.0 False True 1075509.6592321391 1526152.5144191862 2237001.378469837 1.0 1.4190040055137987 2.079945409385673 20.03658905109466 -6.964407832940184 0.3680801055802035 0.9480538643658957 2.5738324683893543 0.9999004050447879 0.004436568359129388 0.07816255618752833 0.015572434438072508 0.008737968175257002 0.05619182012062751 1.0854058727376973e-07 6.964407832940184 1.6257786040234588 up TQEHFTHNTVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQEHFTHNTVR 11 0 Q08209-2;Q08209-3;Q08209;E7ETC2;Q08209-5 Q08209-2 PPP3CA Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 0 4724200.0 1023700.0 1738500.0 1962000.0 False True 1342080.6135249017 1479122.5766199215 1758991.0608329424 1.0 1.1021115734136764 1.3106448622434446 20.35603990050435 -6.959634297890788 0.44055799773167176 0.9925869681575741 1.4283074075251807 0.9997563914254449 0.0020177443354485324 0.07983201908516967 0.02161601031295636 0.002751303746688035 0.017276469385920666 1.0974018856664238e-07 6.959634297890788 0.4357204393676066 TQEHFTHNTVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQEHFTHNTVR 11 0 Q08209-2;Q08209-3;Q08209;E7ETC2;Q08209-5 Q08209-2 PPP3CA Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 0 3808900.0 1446500.0 1192000.0 1170400.0 False True 1400581.6492740694 1667971.8161978798 863837.128752625 1.0 1.1909136586663123 0.6167702748357138 20.41759465953359 -6.817081798831322 1.3846016798238225 1.103212838794572 0.6050177259512153 0.8775095660822688 0.0835543187675274 0.19729901006361772 0.744031034958883 0.047432076132234206 0.10940963115802274 1.523765727367654e-07 6.817081798831322 -0.4981951128433568 TQEHFTHNTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQEHFTHNTVR 11 0 Q08209-2;Q08209-3;Q08209;E7ETC2;Q08209-5 Q08209-2 PPP3CA Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 0 3834200.0 1023700.0 1304200.0 1506300.0 False True 1402189.5544522943 1246576.1315873384 1150542.9632222878 1.0 0.8890211224503526 0.8205331152047403 20.41924996202724 TQEHFTHNTVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQEHFTHNTVR 11 0 Q08209-2;Q08209-3;Q08209;E7ETC2;Q08209-5 Q08209-2 PPP3CA Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 0 3721010.0 1446500.0 1575100.0 699410.0 False True 1202828.8408152522 1566614.623667129 845653.397293537 1.0 1.3024418524960797 0.7030538083210334 20.197999934967868 -6.769544526932372 1.576423387519656 1.1735744437760554 0.6997582734810591 0.728739642399056 0.12744761135608737 0.26716384368811846 1.3102606573233015 0.06373057648733733 0.15175471515005381 1.700025646091254e-07 6.769544526932372 -0.47381617029499623 TQEQLALEMAELTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQEQLALEMAELTAR 15 0 P26038 P26038 MSN Moesin 0 11654100.0 1841100.0 5519200.0 4293800.0 False True 2413699.929237761 4695756.873673096 3849518.7650379604 1.0 1.9454600867291743 1.5948621940978498 21.202814900964263 -10.194216226961162 4.669328236112012 0.9998669201909766 1.7701611404187294 0.8654835276291396 0.14313099032483872 0.00019832469205682964 3.422468164957712e-05 0.13860964028448558 0.04619532848532941 6.394164029547605e-11 10.194216226961162 0.7702942202277528 TQEQLALEMAELTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQEQLALEMAELTAR 15 0 P26038 P26038 MSN Moesin 0 16699100.0 6140500.0 3767200.0 6791400.0 False True 5945573.188639767 5271462.605688469 5012528.602367203 1.0 0.8866197485821343 0.8430690268761074 22.50338447038779 -13.999999999999892 0.13251896052472903 1.5391234439959287 0.7839863468206096 0.999634358236155 0.0012648379482722654 11.933633965241913 0.11344646644723447 1.6721847098725426 0.05259816744633443 1.0000000000002494e-14 13.999999999999892 -0.7551370971753191 TQEQLALEMAELTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQEQLALEMAELTAR 15 0 P26038 P26038 MSN Moesin 0 12394600.0 1841100.0 5466000.0 5087500.0 False True 2521804.4238567143 5224494.046355157 3885937.28035145 1.0 2.0717284801828892 1.540935230182721 21.266024962487155 -10.16427924119724 5.023752388830769 0.9999489452380509 1.806331855184063 0.7547165333501873 0.21669543690673881 0.00012392742429728358 2.0615727829408083e-05 0.2098276615342277 0.06993815152761318 6.850476152175995e-11 10.16427924119724 0.8063829099460121 TQEQLALEMAELTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQEQLALEMAELTAR 15 0 P26038 P26038 MSN Moesin 0 11019100.0 6140500.0 3070000.0 1808600.0 False True 5106097.820273804 3053461.300652712 2186769.8979784288 1.0 0.5980028993038321 0.4282663542589883 22.283789745822066 -13.999999999999988 0.11798935076516918 2.9191872608161926 0.1498689990530733 0.9997028622913133 0.004132614435585253 11.971908525420217 0.10544909086615935 5.402487402615406 0.2470294980112812 1.0000000000000286e-14 13.999999999999988 -2.7693182617631193 TQETLSQAGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQETLSQAGQK 11 0 O43399;O43399-5;O43399-7;A0A087WYR3;O43399-2;O43399-4;O43399-3;O43399-6 O43399;O43399-2 TPD52L2 Tumor protein D54 0 10228400.0 1158800.0 4866100.0 4203500.0 False True 1519198.0218351618 4140096.847909236 3768562.142819197 1.0 2.725185781184785 2.480626020212195 20.534878501376 -9.918228080064965 6.0029811518329845 0.9999994859054079 2.6029059006990516 0.9828407474752253 0.09984110433530947 6.871226392705059e-07 1.2382208778975412e-07 0.09667076383412192 0.032223577862841545 1.2071796895094062e-10 9.918228080064965 1.6029064147936438 TQETLSQAGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQETLSQAGQK 11 0 O43399;O43399-5;O43399-7;A0A087WYR3;O43399-2;O43399-4;O43399-3;O43399-6 O43399;O43399-2 TPD52L2 Tumor protein D54 0 8712500.0 2900800.0 2138400.0 3673300.0 False True 2808715.6918176436 2992274.271608681 2711152.5333621143 1.0 1.0653532076335746 0.9652641387877917 21.421479166460788 -6.730532019061264 1.7214875312921802 1.0393061961766175 0.9653200041258334 0.5616605143383776 0.027471732072142742 0.3352333099439051 1.9465821995114319 0.012645497786910298 0.0313576918020252 1.8598074408641142e-07 6.730532019061264 -0.07398619205078405 TQETLSQAGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQETLSQAGQK 11 0 O43399;O43399-5;O43399-7;A0A087WYR3;O43399-2;O43399-4;O43399-3;O43399-6 O43399;O43399-2 TPD52L2 Tumor protein D54 0 16669200.0 2577300.0 12131000.0 1960900.0 False True 3909952.525868645 9966128.270064391 1573327.2555069986 1.0 2.548912858692649 0.40239037305381714 21.898719659948956 -6.713102097507772 1.7841941748579946 1.9492041923518972 0.40696721043385237 0.4798111949334426 0.6523956208761778 0.36886911704019054 2.2908482434008075 0.2907799589229423 0.7359392829009819 1.935966787499174e-07 6.713102097507772 -1.5422369819180448 TQETLSQAGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQETLSQAGQK 11 0 O43399;O43399-5;O43399-7;A0A087WYR3;O43399-2;O43399-4;O43399-3;O43399-6 O43399;O43399-2 TPD52L2 Tumor protein D54 0 9724500.0 1158800.0 4616000.0 3949700.0 False True 1587239.675392515 4412049.856929271 3016862.2066248893 1.0 2.7796998306750345 1.9006973259276907 20.59808856289889 -10.098530034336015 5.649308257486608 0.9999891736756007 2.3401985783015786 0.756070011360554 0.35885126987732036 4.8932737537275554e-05 7.809487544005348e-06 0.34745904716276294 0.1158187493332426 7.970213693848205e-11 10.098530034336015 1.3402094046259778 TQETLSQAGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQETLSQAGQK 11 0 O43399;O43399-5;O43399-7;A0A087WYR3;O43399-2;O43399-4;O43399-3;O43399-6 O43399;O43399-2 TPD52L2 Tumor protein D54 0 5287440.0 2900800.0 1694000.0 692640.0 False True 2412143.727229094 1684874.0857673285 837467.8215944818 1.0 0.6984965558842535 0.34718819286797126 21.201884441895064 -7.071975543668405 0.2929969774174172 1.0705506310333854 3.2767929178109376e-12 0.9999655979145454 0.0015646698201029106 0.0739798663737585 0.0114136293527388 0.006741797309592485 0.03139134547762646 8.472751252188022e-08 7.071975543668405 -1.0705506310301087 down TQGFLALFSGDTGEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQGFLALFSGDTGEIK 16 0 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 0 19497000.0 3743800.0 7866600.0 7886600.0 False True 4908158.055010776 6692933.943766637 7070570.2856091205 1.0 1.363634558779901 1.4405751009568082 22.226750277475094 -12.313009708621326 0.24654408108094306 2.4491447449387994e-13 1.4749921593949182 0.9994093893399154 0.004669449737454137 6.07971328778744 0.14724242037175528 3.0830025088155253 0.036158194978865604 4.863963322155513e-13 12.313009708621326 1.4749921593946733 TQGFLALFSGDTGEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQGFLALFSGDTGEIK 16 0 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 0 37764400.0 15281000.0 7967400.0 14516000.0 False True 14795913.019396506 11148824.36944212 10713824.129334502 1.0 0.7535070228398015 0.7241069959852667 23.818695388652387 -13.999999999999998 0.2999914338190278 3.24832029837894 0.7168724617892528 0.9996498101163658 0.0023150447405575637 16.587721287257445 0.17394386043028967 23.14906680643914 0.010625243593356952 1.0000000000000041e-14 13.999999999999998 -2.5314478365896873 TQGFLALFSGDTGEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQGFLALFSGDTGEIK 16 0 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 0 61568000.0 16588000.0 29032000.0 15948000.0 False True 25165208.745240763 23851012.771948654 12795870.809743296 1.0 0.9477772671549705 0.5084746540067245 24.584927229241845 -6.929174623807126 0.7535469995624297 1.0068894361900345 0.4201580952826534 0.9963732649117302 0.013274919750724392 0.09306912028202512 0.07979965175626767 0.0120351382162332 0.03993141298696295 1.1771325696200177e-07 6.929174623807126 -0.5867313409073811 TQGFLALFSGDTGEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQGFLALFSGDTGEIK 16 0 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 0 29605800.0 3743800.0 11054000.0 14808000.0 False True 5127984.03239084 10565597.729310263 11310655.380333045 1.0 2.0603803878040203 2.2056728938486247 22.289960338997986 -10.773506288793362 0.38195452232786264 3.774011544773189e-22 2.222127736868429 0.9993722681686421 0.01346426311327977 2.405236430180021 0.18541794809107137 2.24417983763243 0.03901711144679306 1.6845880329510013e-11 10.773506288793362 2.222127736868429 TQGFLALFSGDTGEIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQGFLALFSGDTGEIK 16 0 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 0 31323700.0 15281000.0 6974700.0 9068000.0 False True 12706828.563081827 6937125.906730444 10964076.874305207 1.0 0.5459368458692703 0.862849201110655 23.599100664086663 -10.112747257127888 5.753348946657945 1.0000023229509833 0.7043930234899394 0.5370552211060104 0.12937892725425618 3.855059246311857e-06 5.944028518056851e-07 0.1252715931416093 0.0417568692171473 7.713522361357437e-11 10.112747257127888 -0.295609299461044 TQGFLALFSGDTGEIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQGFLALFSGDTGEIK 16 0 Q9Y230;Q9Y230-2;M0R0Y3 Q9Y230 RUVBL2 RuvB-like 2 0 48649000.0 16588000.0 18419000.0 13642000.0 False True 21473492.998364225 17393966.45839773 11159295.978740547 1.0 0.8100203567124706 0.519677724513223 24.356053551334295 -6.96494500243578 0.35899644294721217 1.025307403486924 0.29445649361830967 0.9999120047015735 0.0018527727527635903 0.07797964318513266 0.01492588320426488 0.0039034120499983217 0.02481388678099196 1.0840641875011163e-07 6.96494500243578 -0.7308509098686145 TQIAICPNNHEVHIYEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQIAICPNNHEVHIYEK 17 0 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7;C9JTT6 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 14463200.0 4947100.0 4975500.0 4540600.0 False True 6485696.007784553 4233174.7943471 4070782.268510732 1.0 0.6526939883192442 0.6276554225829757 22.628829973885757 -13.999999999755603 0.3732741055137103 5.9384297007283555 0.6251917598513932 0.9997964512980438 0.0024244070113123113 23.20708215030987 0.19860673625925115 91.83515686679021 0.006926885005782911 1.0000000005627437e-14 13.999999999755603 -5.313237940876962 TQIAICPNNHEVHIYEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQIAICPNNHEVHIYEK 17 0 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7;C9JTT6 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 23368200.0 3917400.0 10647000.0 8803800.0 False True 5942982.200301791 8746959.664609313 7063725.071157375 1.0 1.4718132024970787 1.1885825723655494 22.502755629294303 -10.374640868439755 5.142825800483253 0.9997992473836644 1.3301978874313378 0.6444069118038462 0.11562842055828228 0.00026631202625831274 3.2383189625976805e-05 0.1120241639958633 0.03731891226419597 4.2204536155109285e-11 10.374640868439755 0.3303986400476734 TQIAICPNNHEVHIYEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQIAICPNNHEVHIYEK 17 0 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7;C9JTT6 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 12822400.0 4947100.0 3075000.0 4800300.0 False True 6776176.560350641 2939136.332334817 3666568.0052817836 1.0 0.4337455357247551 0.5410968814974404 22.69204003540865 -9.968257340821726 5.850477584969911 1.0000004715994968 0.4874212086111976 0.9681508374530977 0.04382600339133274 2.695292480869499e-07 4.755539199566233e-08 0.04243438388592104 0.01414478177202847 1.0758275440372817e-10 9.968257340821726 -0.5125792629882993 TQIAICPNNHEVHIYEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQIAICPNNHEVHIYEK 17 0 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7;C9JTT6 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 14893100.0 3917400.0 5872300.0 5103400.0 False True 5071151.52349843 5545501.342833434 4174633.5653059976 1.0 1.0935388771439756 0.8232121532874347 22.273881951386752 -6.813246855914486 1.4006882990618346 1.0507857135588197 0.8181160741908517 0.8681796165783883 0.040697050055689465 0.20240014514273452 0.7819747099779057 0.02284137954371255 0.05276723693940018 1.5372805912559888e-07 6.813246855914486 -0.23266963936796792 TQILAASYELHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQILAASYELHK 12 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 23745900.0 9416600.0 8168400.0 6160900.0 False True 12345253.79048411 6949706.560173816 5523429.167525827 1.0 0.5629456208936543 0.4474131728084328 23.55745315954272 -13.999999999999998 0.18676624716781526 3.3173001040110996 0.3617772166129182 0.9994915160782061 0.005366380262687433 12.299840234178749 0.13704097461354414 10.36187943231518 0.08154514263435396 1.0000000000000041e-14 13.999999999999998 -2.9555228873981814 TQILAASYELHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQILAASYELHK 12 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 19878500.0 4115400.0 4070100.0 11693000.0 False True 3984758.879656067 5695312.155291099 8630252.517519182 1.0 1.4292739729794324 2.165815493022774 21.92606099776854 -6.962927821919411 0.39199308483967676 0.9557568056187792 2.665882055475319 0.9998638530332926 0.005617314705540799 0.07867134767648634 0.017384565551384366 0.009499764870251608 0.061904778245828684 1.089111084386555e-07 6.962927821919411 1.7101252498565396 up TQILAASYELHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQILAASYELHK 12 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 26280300.0 5584700.0 14203000.0 6492600.0 False True 8472398.196259104 11668363.681454498 5209334.764192331 1.0 1.377220877862721 0.6148595289693132 23.01433896581544 -6.772171048958623 1.5662302337200265 1.2157629226608841 0.6102238407233538 0.7387710631049269 0.15907564650949146 0.262930108691214 1.2732117644026542 0.08004396324503674 0.19015413224082084 1.6897752744928755e-07 6.772171048958623 -0.6055390819375304 TQILAASYELHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQILAASYELHK 12 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 22432200.0 9416600.0 4847800.0 8167800.0 False True 12898171.494046565 4633608.166469177 6238733.861121304 1.0 0.3592453526151301 0.4836913405904805 23.620663221065612 -10.235880181134137 6.019284248334858 1.000014550326415 0.4214683466047325 0.9664607729942597 0.0508048618460315 9.920623268513885e-06 1.2593618733810344e-06 0.04919283126504056 0.016397198653002855 5.809246685418693e-11 10.235880181134137 -0.5785462037216826 TQILAASYELHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQILAASYELHK 12 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 14808700.0 4115400.0 5494800.0 5198500.0 False True 3422137.4431324475 5465198.421767601 6285482.314851742 1.0 1.5970131277851427 1.8367124112637443 21.706466273202818 -10.847511280871878 0.18171381622597121 1.1504364477465925e-17 2.0682750006460466 0.9994769040874356 0.008046475071918142 2.8508260064186373 0.10015449274606443 1.3877491883638233 0.17044386203323456 1.4206553106213717e-11 10.847511280871878 2.0682750006460466 TQILAASYELHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQILAASYELHK 12 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 21869700.0 5584700.0 10129000.0 6156000.0 False True 7229504.240894901 9565312.245893419 5035671.165894061 1.0 1.3230938010639277 0.6965444653049575 22.78546528790789 -6.766525069440883 1.5875708096143502 1.186136950104002 0.6934581269757903 0.7171703039569319 0.13605460627622026 0.2720805524537937 1.3527585598392307 0.06757029988894225 0.16137560419466815 1.7118863560310187e-07 6.766525069440883 -0.49267882312821165 TQIQSQESDLK(ub)SQEDDLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQIQSQESDLKSQEDDLNR 19 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R2S2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 24454300.0 10356000.0 10098000.0 4000300.0 True False 13576816.287646644 8591417.761695698 3586387.329587169 1.0 0.6328006197972134 0.26415525213008684 23.69464187689307 -7.489887223493303 0.315167747821993 1.0774035781584155 1.1441076320048369e-11 0.9996418177351288 0.005685421454557022 0.12240039420653182 0.03293414739714968 0.021348169331991025 0.06443728546722824 3.236776978337919e-08 7.489887223493303 -1.0774035781469744 down TQIQSQESDLK(ub)SQEDDLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQIQSQESDLKSQEDDLNR 19 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R2S2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 25693000.0 7685900.0 8485700.0 9521400.0 True False 7441915.311548958 11874084.26234091 7027459.704122737 1.0 1.595568313430517 0.9443079382020062 22.827242542117403 -6.666156949257019 1.9511944204438565 1.3814046289876456 0.9469922243289556 0.262034745351559 0.25321202906948925 0.4700142822095578 3.4460843292348393 0.10461807569486414 0.2809012896470528 2.1569647649020857e-07 6.666156949257019 -0.43441240465869 TQIQSQESDLK(ub)SQEDDLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQIQSQESDLKSQEDDLNR 19 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R2S2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 71457000.0 18188000.0 30490000.0 22779000.0 True False 27592525.720909007 25048821.280542664 18276720.665609628 1.0 0.9078118304175837 0.6623794012361809 24.717774186080423 -6.954100131642618 0.5118567293014018 1.0044488969836265 0.5549407116917123 0.9994849997544799 0.0032335446390268936 0.0818799319152659 0.029463078031933872 0.003712584740526228 0.02025873802658278 1.1114754341518779e-07 6.954100131642618 -0.44950818529191416 TQIQSQESDLK(ub)SQEDDLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQIQSQESDLKSQEDDLNR 19 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R2S2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 25245000.0 10356000.0 9540400.0 5348600.0 True False 14184893.060377011 9118873.582116123 4085370.8378747497 1.0 0.6428581127331924 0.288008575072484 23.75785193841596 -7.439904389103723 0.29775734616963667 1.0863888160621689 1.6894990569852199e-12 0.9997654760517447 0.004451364126808422 0.11985029104477986 0.027776855231336554 0.01980300266137592 0.060471717160185984 3.631579960108226e-08 7.439904389103723 -1.0863888160604793 down TQIQSQESDLK(ub)SQEDDLNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQIQSQESDLKSQEDDLNR 19 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R2S2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 24148300.0 7685900.0 11449000.0 5013400.0 True False 6391166.3931019325 11387321.964551438 6061678.76065744 1.0 1.7817282893529294 0.9484464005192992 22.60764781755168 -6.660544171446039 1.9707839390664883 1.5029576815477057 0.9519045145162361 0.23799607470251383 0.33279777318626985 0.4831525932570597 3.6079315907117757 0.13639684436644317 0.3689859972673461 2.185022073004955e-07 6.660544171446039 -0.5510531670314696 TQIQSQESDLK(ub)SQEDDLNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQIQSQESDLKSQEDDLNR 19 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R2S2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 61730000.0 18188000.0 29444000.0 14098000.0 True False 23544724.539079346 27805415.516643826 11532308.657695657 1.0 1.180961598021358 0.4898043567489789 24.488900508172872 -6.837136148055714 1.2956415107457389 1.0963295649597575 0.46833149496297527 0.9194204872417084 0.08307042422048995 0.17216549619798652 0.5626440232778526 0.05029777506439074 0.11580183075984134 1.4550028766121177e-07 6.837136148055714 -0.6279980699967822 down TQK(ub)EIEQEAAVELSQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQKEIEQEAAVELSQLR 17 1 P47985 P47985 UQCRFS1 Cytochrome b-c1 complex subunit Rieske, mitochondrial;Cytochrome b-c1 complex subunit 11 1 25935300.0 9284700.0 8079600.0 8571000.0 True False 8989962.280687839 11305826.414557392 6325997.975511576 1.0 1.2576055451138513 0.7036734724795266 23.099883631940564 -6.780239480782961 1.5348661733037072 1.1458158260965035 0.6992465085098989 0.7682690681734892 0.108949761523291 0.2501974703228955 1.1642208213505076 0.055906331749775606 0.13189302197493583 1.6586720221932023e-07 6.780239480782961 -0.44656931758660456 TQK(ub)EIEQEAAVELSQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQKEIEQEAAVELSQLR 17 1 P47985 P47985 UQCRFS1 Cytochrome b-c1 complex subunit Rieske, mitochondrial;Cytochrome b-c1 complex subunit 11 1 38184000.0 11398000.0 11919000.0 14867000.0 True False 17291599.30541683 9791961.326427946 11928530.933562422 1.0 0.5662843068171537 0.6898454401395738 24.043567974677476 -10.438567007795447 8.956950515455882 1.0000034812857088 0.6280648734783671 0.923554297441114 0.05044362144665548 3.5068137220631883e-06 2.19799767092439e-07 0.048842283254824495 0.01628060881544066 3.6427804085414136e-11 10.438567007795447 -0.37193860780734167 TQK(ub)EIEQEAAVELSQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQKEIEQEAAVELSQLR 17 1 P47985 P47985 UQCRFS1 Cytochrome b-c1 complex subunit Rieske, mitochondrial;Cytochrome b-c1 complex subunit 11 1 25688900.0 9284700.0 10568000.0 5836200.0 True False 7720639.431951177 10511068.086416245 7056522.436460076 1.0 1.3614245528572577 0.913981607178453 22.88028890737484 -6.69177756659577 1.8602509898065605 1.226212287954021 0.9154999665652288 0.37871934692792997 0.1528023544041043 0.41284274806572757 2.7713154153264505 0.06568027471416257 0.1706442325962998 2.033398193577055e-07 6.69177756659577 -0.3107123213887921 TQK(ub)EIEQEAAVELSQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQKEIEQEAAVELSQLR 17 1 P47985 P47985 UQCRFS1 Cytochrome b-c1 complex subunit Rieske, mitochondrial;Cytochrome b-c1 complex subunit 11 1 28231000.0 11398000.0 16833000.0 0.0 True False 14754935.688169496 15896228.75260378 0.0 1.0 1.0773499179226766 0.0 23.814694296769925 -6.972555257285427 1.1654086999790918 1.0496911062919592 2.544926456942363e-21 0.9781300438007917 0.07256023326526483 0.09933623865898746 0.26641907508409146 0.052130210314188935 0.09734902890575448 1.0652333205076011e-07 6.972555257285427 -1.0496911062919592 down TQK(ub)EIEQEAAVELSQLRDPQHDLDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQKEIEQEAAVELSQLRDPQHDLDR 25 2 P47985 P47985 UQCRFS1 Cytochrome b-c1 complex subunit Rieske, mitochondrial;Cytochrome b-c1 complex subunit 11 1 42356200.0 11675200.0 12109000.0 18572000.0 True False 17712131.971451335 9948054.34195117 14901236.059603224 1.0 0.5616519997697389 0.8413010971023278 24.07823454087053 -10.576528837799774 6.418797477794739 1.0005712192392422 0.7014765484360337 0.6030782676690318 0.11416626591579186 0.000934964991466276 6.16829278813155e-05 0.11074462355542537 0.036847003882545776 2.651375031916882e-11 10.576528837799774 -0.2990946708032085 TQK(ub)FFEMIENHPLSTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQKFFEMIENHPLSTK 16 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 10454000.0 1038700.0 3685000.0 5730300.0 True False 1361745.7587851076 3135212.3640175 5137383.524918961 1.0 2.3023478088998086 3.7726451444962232 20.377025943174665 -6.96954963968195 0.26872411053809536 0.6287950721078953 5.49032427556145 0.999978654240867 0.005232866132430495 0.07644910282188488 0.009551795486677922 0.029047954774100954 0.13698737949277218 1.072631039538783e-07 6.96954963968195 4.861529203453555 TQK(ub)FFEMIENHPLSTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQKFFEMIENHPLSTK 16 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 16340100.0 5446200.0 3697800.0 7196100.0 True False 5273313.362099162 5174350.823772251 5311225.531627446 1.0 0.9812333287382115 1.0071894399071313 22.330278299497976 -6.712743463635218 1.7854037221543184 0.9884950825323767 1.0071335569092497 0.4781121902040788 0.007904878367747486 0.36959819056269694 2.298261745747022 0.0035211297541512887 0.008915761835080435 1.9375661401196197e-07 6.712743463635218 0.018638474376872938 TQK(ub)FFEMIENHPLSTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQKFFEMIENHPLSTK 16 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 64129400.0 7040900.0 19773500.0 37315000.0 True False 10681560.0587392 16244764.433939338 29939673.894254513 1.0 1.5208232079029091 2.802930819993765 23.34861903451792 -6.9557917443930055 0.491164703142562 0.9722359474172905 3.4059926943673995 0.9995808869430975 0.015509770869898255 0.0812400901395285 0.02695750054261941 0.01850613485466168 0.10574463218879421 1.1071545663896973e-07 6.9557917443930055 2.433756746950109 TQK(ub)FFEMIENHPLSTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQKFFEMIENHPLSTK 16 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 9937100.0 1038700.0 2923000.0 5975400.0 True False 1422735.4598120518 2793852.1949315965 4564133.587225963 1.0 1.9637186770481379 3.2079987574281033 20.440236004697557 -6.96762937205092 0.30962488209841804 0.807457183353681 4.40379055395156 0.9999575387535643 0.005889587722764201 0.07707970949622825 0.011769840366079788 0.019720464006289434 0.11050850946098814 1.0773842637205358e-07 6.96762937205092 3.596333370597879 TQK(ub)FFEMIENHPLSTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQKFFEMIENHPLSTK 16 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 17873200.0 5446200.0 6139700.0 6287300.0 True False 4528756.607568633 6106624.217464973 7601945.360809339 1.0 1.3484107773112264 1.67859437358693 22.110683574932253 -6.971776587909266 0.21149730096698297 0.8303979111375426 2.2058402068703087 0.9999931218588903 0.0007266222238465434 0.07573036148549189 0.006928587132790214 0.009770940892990505 0.034097487847570405 1.0671449464656332e-07 6.971776587909266 1.375442295732766 TQK(ub)FFEMIENHPLSTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQKFFEMIENHPLSTK 16 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 42430500.0 7040900.0 18923600.0 16466000.0 True False 9114583.846888281 17870485.024818685 13469356.95542749 1.0 1.9606473893944887 1.4777807941309278 23.11974535661037 -10.21942717255201 4.887698578170489 0.9998899339225809 1.7192140917639152 0.7473482836146049 0.19712946204262313 0.0002364703867390528 3.7764688816153726e-05 0.1908986921075668 0.06362326029423135 6.033548768654429e-11 10.21942717255201 0.7193241578413343 TQLAVCQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQLAVCQQR 9 0 Q02790;H0YFG2 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 23789800.0 5977500.0 9376700.0 8435600.0 False True 7836560.38619235 7977732.910090327 7562765.031988982 1.0 1.0180146029560007 0.9650617948805981 22.90178913659195 -6.814907801606858 1.3938270805785618 1.009762415188084 0.9640278705838032 0.872254346034824 0.007856997199511509 0.20018123646437572 0.7655080671592602 0.004431247103908778 0.01022942207746787 1.5314125378569066e-07 6.814907801606858 -0.045734544604280725 TQLAVCQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQLAVCQQR 9 0 Q02790;H0YFG2 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 15081100.0 5832500.0 3433300.0 5815300.0 False True 5647350.480049082 4804234.59442297 4292098.474739523 1.0 0.8507059392533427 0.7600198517698904 22.42914273847555 TQLAVCQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQLAVCQQR 9 0 Q02790;H0YFG2 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 64622900.0 10005000.0 44720000.0 9897900.0 False True 15178316.463475624 36739366.60104526 7941575.726596322 1.0 2.420516576357669 0.5232184837960488 23.855508444128986 -6.70630229473971 1.808262795530676 1.87656826468499 0.5281172940475671 0.4476039704617317 0.598954183509596 0.3825449636350538 2.435913358377313 0.2638183358179565 0.673275912848196 1.9665170006413498e-07 6.70630229473971 -1.3484509706374228 TQLAVCQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQLAVCQQR 9 0 Q02790;H0YFG2 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 22154700.0 5977500.0 7629600.0 8547600.0 False True 8187543.28586363 7292499.044286731 6528832.923347822 1.0 0.8906821972932643 0.7974104924269912 22.964999198114842 -6.972969302154452 0.17314458211935155 1.0789996430239401 0.6065877063500296 0.9999972389441444 0.0001374515847408556 0.07535047028493547 0.005419146819529716 0.003819402461390206 0.010694978984273684 1.0642182391951626e-07 6.972969302154452 -0.47241193667391057 TQLAVCQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQLAVCQQR 9 0 Q02790;H0YFG2 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 11876600.0 5832500.0 2851900.0 3192200.0 False True 4849982.173560282 2836536.2486421703 3859674.2609348376 1.0 0.5848549844379988 0.7958120510165756 22.209548013909828 -10.271137931011626 4.784717815054813 1.0001008071143447 0.6903335177268177 0.7418036998116277 0.08612286179369402 9.264296235057833e-05 1.4112302049061665e-05 0.08341514409606991 0.02779603412098087 5.3562651664440665e-11 10.271137931011626 -0.30976728938752696 TQLAVCQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQLAVCQQR 9 0 Q02790;H0YFG2 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed 0 33977000.0 10005000.0 11057000.0 12915000.0 False True 12951669.728034357 10441668.230115838 10564602.51909061 1.0 0.8062024780877843 0.8156942495393583 23.626634766221436 -9.989332948512919 5.5112904027123 1.0000005087457562 0.810948363814596 0.998112983937485 0.0038749994694176923 2.422314372055001e-08 4.443247995204511e-09 0.0037519622218294686 0.001250650700846413 1.0248659194490537e-10 9.989332948512919 -0.18905214493116018 TQLEELEDELQATEDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQLEELEDELQATEDAK 17 0 P35579;P35579-2;P35749-2;P35749;P35749-3;P35749-4;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35580 MYH9;MYH11;MYH10 Myosin-9;Myosin-11;Myosin-10 0 28779200.0 8725600.0 3864600.0 16189000.0 False True 8448610.604151972 5407754.933622757 11948615.240410333 1.0 0.6400762429464057 1.414269848646868 23.010282675297546 -6.780280577665665 1.534651273120666 0.7962743574086073 1.4204696982057932 0.7684087359975036 0.15222690645781878 0.2501465971201932 1.16365202959312 0.07812295158084544 0.18430389948389686 1.6585150710293534e-07 6.780280577665665 0.6241953407971859 TQLEINGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQLEINGR 8 0 Q9NR56;C9JP00;A0A0A0MQX8;Q9NR56-6;Q9NR56-7;Q9NR56-4;H7C4T5;Q9NR56-3;Q9NR56-2;Q9NR56-5;Q5VZF2-3;Q5VZF2-2;O95205;Q5VZF2;Q86VM6;Q9NUK0-4;Q9NUK0-3;C9J4T8;B1AKI6;Q9NUK0-2;Q9NUK0 Q9NR56;B1AKI6 MBNL1;MBNL2;MBLL;MBNL3 Muscleblind-like protein 1;Muscleblind-like protein 2;Muscleblind-like protein 3 0 10849500.0 2253600.0 4193800.0 4402100.0 False True 2954491.423893441 3568101.3873043656 3946612.919924917 1.0 1.2076871702684813 1.335801108782389 21.494478380480526 -11.210278413535736 0.06186388421206845 4.473478779470479e-18 1.9707116891763454 0.9999779353737543 0.0006499269454246133 3.887613539525728 0.04069088041471983 0.9646048051937881 0.4189094306107554 6.161998474496933e-12 11.210278413535736 1.9707116891763454 TQLEINGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQLEINGR 8 0 Q9NR56;C9JP00;A0A0A0MQX8;Q9NR56-6;Q9NR56-7;Q9NR56-4;H7C4T5;Q9NR56-3;Q9NR56-2;Q9NR56-5;Q5VZF2-3;Q5VZF2-2;O95205;Q5VZF2;Q86VM6;Q9NUK0-4;Q9NUK0-3;C9J4T8;B1AKI6;Q9NUK0-2;Q9NUK0 Q9NR56;B1AKI6 MBNL1;MBNL2;MBLL;MBNL3 Muscleblind-like protein 1;Muscleblind-like protein 2;Muscleblind-like protein 3 0 11354900.0 4060200.0 1354700.0 5940000.0 False True 3931311.173441113 1895638.774667172 4384135.80381971 1.0 0.4821899592872731 1.1151841231591535 21.90657913064735 -6.689264273006312 1.8690885117331384 0.6751431753906193 1.1129744428696167 0.366982326986511 0.21902975675057576 0.4182379344099042 2.832276893253161 0.09376820836078668 0.24440035180372707 2.0451997312865596e-07 6.689264273006312 0.43783126747899737 TQLIQLSTLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQLIQLSTLLR 11 0 Q8TC07-2;Q8TC07-3;Q8TC07 Q8TC07-2 TBC1D15 TBC1 domain family member 15 0 8452200.0 2604100.0 2759000.0 3089100.0 False True 3414000.3181402734 2347367.9544977653 2769469.564739574 1.0 0.687571100103605 0.8112095215762024 21.70303176213018 -10.196286601088634 4.795088702029408 1.0000350849091428 0.7493903108390297 0.8456330254647252 0.050475174204848657 1.893468648292379e-05 3.1735614242263346e-06 0.04887921245924618 0.01629079242393035 6.36375423277641e-11 10.196286601088634 -0.2506447740701131 TQLIQLSTLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQLIQLSTLLR 11 0 Q8TC07-2;Q8TC07-3;Q8TC07 Q8TC07-2 TBC1D15 TBC1 domain family member 15 0 13372000.0 5231900.0 4857800.0 3282300.0 False True 5065816.198297263 6797544.873092344 2422567.1631106813 1.0 1.3418459349901315 0.4782185275346077 22.27236330239205 -6.799347802686616 1.4589231614980656 1.188767941803797 0.46653444245968156 0.8301490999354931 0.14635388628968085 0.221693283545687 0.931698448704708 0.07892694837832523 0.18359984453414668 1.5872750777034976e-07 6.799347802686616 -0.7222334993441155 down TQLIQLSTLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQLIQLSTLLR 11 0 Q8TC07-2;Q8TC07-3;Q8TC07 Q8TC07-2 TBC1D15 TBC1 domain family member 15 0 13172200.0 2604100.0 5043700.0 5524400.0 False True 3566906.143156414 4820852.656714507 4219650.498589399 1.0 1.3515501847347335 1.183000148934494 21.766241823653072 -10.544127176789852 5.791090347741726 0.9993877089967514 1.2672751668346118 0.7702589916806328 0.06881026397307093 0.0005451776075508204 4.291616411488106e-05 0.06677342174602421 0.022208417201319972 2.8567538622717942e-11 10.544127176789852 0.2678874578378604 TQLIQLSTLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQLIQLSTLLR 11 0 Q8TC07-2;Q8TC07-3;Q8TC07 Q8TC07-2 TBC1D15 TBC1 domain family member 15 0 8984400.0 5231900.0 1828600.0 1923900.0 False True 4350556.662468931 1818748.9688513172 2326178.594891463 1.0 0.41804971408398606 0.5346852771643622 22.052768577826328 -9.962939985696503 6.356562309363077 1.0000001339337372 0.47636749562457226 0.9641240848897994 0.047616269234924805 9.040168396066983e-08 1.4752705907173117e-08 0.046104266461257606 0.01536808481293889 1.0890805808469288e-10 9.962939985696503 -0.523632638309165 TQLQQLGVTLSMTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQLQQLGVTLSMTR 14 0 Q7Z3B4;Q7Z3B4-3;Q7Z3B4-2 Q7Z3B4 NUP54 Nucleoporin p54 0 41571000.0 9199000.0 15339000.0 17033000.0 False True 13955555.53698275 12601635.605845977 13666420.084170891 1.0 0.9029834442957978 0.9792816952327237 23.73433621996611 -10.507407512936046 5.6405759586086255 1.0000980315260601 0.9411325697644536 0.44249506343847067 0.031148630510383014 3.8464125568242764e-05 3.359092166411544e-06 0.03020971175204477 0.010053177268656777 3.108797879778243e-11 10.507407512936046 -0.05896546176160655 TQLVSNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQLVSNLK 8 0 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 3256670.0 1369600.0 1371700.0 515370.0 False True 1138883.083567623 1364310.379838868 623131.4841983545 1.0 1.1979371715357119 0.5471426287642766 20.11918821855205 -6.825105705713441 1.3496964541961152 1.106169867860159 0.5313240332626976 0.8957209709271398 0.08796258612858796 0.18692433706260966 0.6676639886834377 0.05119551191510584 0.11786463516252044 1.4958715220384242e-07 6.825105705713441 -0.5748458345974614 TQLVSNLKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQLVSNLKK 9 1 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 3983050.0 773050.0 1279900.0 1930100.0 False True 1013476.0362268487 1088943.9090111253 1730391.7668265342 1.0 1.0744643879940585 1.707383011510315 19.950880545819743 -6.928985570219495 0.7550657432730987 0.9900048568827238 1.83402686556935 0.9963353038430004 0.01921262930389597 0.09316749885714734 0.08028356056951312 0.01739931965818453 0.05759072011132357 1.1776451010684211e-07 6.928985570219495 0.8440220086866261 TQLVSNLKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQLVSNLKK 9 1 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 9415600.0 1818300.0 6346500.0 1250800.0 False True 2758494.035536006 5213917.489569173 1003578.8317548856 1.0 1.8901318699266467 0.3638140299838927 21.395449430378132 -6.7485958740000855 1.6548103902073281 1.524279163085031 0.3610591129546506 0.6430096521560265 0.37401762774698044 0.30249672684246354 1.6293122425971975 0.17857001605189238 0.4342000296755273 1.784038104304147e-07 6.7485958740000855 -1.1632200501303804 TQLVSNLKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQLVSNLKK 9 1 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 3675850.0 773050.0 1668600.0 1234200.0 False True 1058867.4758907354 1594875.7346776829 942707.3791468812 1.0 1.506209011978623 0.8902977951550183 20.014090607342634 -6.688333563032588 1.8724942771465038 1.317855182992518 0.8924757095899513 0.36260685751896726 0.21416352353040885 0.42023672204724277 2.8554802974517313 0.0915453246375183 0.23887852191857353 2.049587373657225e-07 6.688333563032588 -0.42537947340256677 TQLVSNLKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQLVSNLKK 9 1 P00505;P00505-2 P00505 GOT2 Aspartate aminotransferase, mitochondrial 0 4669700.0 1818300.0 1099000.0 1752400.0 False True 2353825.1940514627 1037839.6839013583 1433481.1811424212 1.0 0.44091621014345705 0.6090006958737142 21.16657575247058 -10.90367289738467 11.364446268734586 1.0381968379912954 0.5249584530085856 0.9141625580955217 0.06862020395287505 0.035901544953701146 0.0003043074387770905 0.035918729680906016 0.02214707559357012 1.2483233744597048e-11 10.90367289738467 -0.5132383849827098 TQLYDK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQLYDKQR 8 1 Q9BVK6 Q9BVK6 TMED9 Transmembrane emp24 domain-containing protein 9 1 21137510.0 367010.0 3655500.0 17115000.0 True False 556781.0020250066 3003147.4644481367 13732212.748229 1.0 5.3937678432376845 24.663579932298497 19.086750460135118 -6.942765987162889 0.6333099262048952 0.7897056058240532 30.312085782007536 0.9985041935072642 0.3974792059618797 0.08652717512411522 0.04903156374905903 0.3955656340140043 1.6393760843912897 1.140864359012732e-07 6.942765987162889 29.522380176183482 TQMK(ub)MSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQMKMSLK 8 1 Q9UK73;H3BT12 Q9UK73 FEM1B Protein fem-1 homolog B 1 5154700.0 1522100.0 1926400.0 1706200.0 True False 1995487.8400373694 1638988.629048385 1529658.791026078 1.0 0.8213473398152562 0.7665588135066922 20.928310056807167 -13.999999999999291 0.16555194687253905 1.890944814495176 0.7158672742901475 0.9995228744465174 0.002177181944775659 12.051291414536577 0.12874582196459605 3.4471898088439508 0.04654424510503202 1.000000000001632e-14 13.999999999999291 -1.1750775402050284 TQMK(ub)MSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQMKMSLK 8 1 Q9UK73;H3BT12 Q9UK73 FEM1B Protein fem-1 homolog B 1 5248700.0 1195100.0 1774300.0 2279300.0 True False 1157162.2046646671 2482787.2428522687 1682282.9524657049 1.0 2.14558273061792 1.4538004660748594 20.142159677039505 -10.174054320506773 4.716838552383758 0.9999535253516867 1.7996915983236106 0.6405130996886446 0.2824189286866379 0.00030188480013319525 5.2861496968004774e-05 0.27348536161077125 0.09115031701507872 6.69800827104333e-11 10.174054320506773 0.7997380729719239 TQMK(ub)MSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQMKMSLK 8 1 Q9UK73;H3BT12 Q9UK73 FEM1B Protein fem-1 homolog B 1 10976800.0 4050500.0 3065300.0 3861000.0 True False 6144904.6312152 2518273.2657017848 3097871.6576635856 1.0 0.40981486562205244 0.5041366536311823 22.55095918950054 -10.809644158753393 7.290233717297458 1.0222372277762013 0.45697575962661774 0.977872660782549 0.03850670870822217 0.012715639426000718 0.0003320185592553927 0.034064332284828205 0.012427986795350385 1.55008616920093e-11 10.809644158753393 -0.5652614681495836 TQMK(ub)MSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQMKMSLK 8 1 Q9UK73;H3BT12 Q9UK73 FEM1B Protein fem-1 homolog B 1 5064900.0 1522100.0 1696900.0 1845900.0 True False 2084861.5032058605 1621925.3471020982 1409936.4375038329 1.0 0.7779535209451984 0.6762734288756326 20.991520118330058 -13.999999998975039 0.10497957475759036 2.0823647023641016 0.4755021490628927 0.9997685786276845 0.0020562960135454425 12.044530225884674 0.0974612941749304 2.79130994878401 0.1786231885552829 1.0000000023600609e-14 13.999999998975039 -1.6068625533012089 TQMK(ub)MSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQMKMSLK 8 1 Q9UK73;H3BT12 Q9UK73 FEM1B Protein fem-1 homolog B 1 5855400.0 1195100.0 3472200.0 1188100.0 True False 993778.6019068846 3453494.569422258 1436526.216846274 1.0 3.4751146410232776 1.4455193682877006 19.92256495247378 -6.597041926662343 2.2019530024789744 2.6676725052018337 1.451878286201455 0.012267602245268017 1.0706080774896571 0.6489660827800916 5.942266684187218 0.4042648703007005 1.1915539021646624 2.529053830542897e-07 6.597041926662343 -1.2157942190003788 TQNLAALLHAIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQNLAALLHAIAR 13 0 Q6P179-3;Q6P179;H0Y9X9 Q6P179-3 ERAP2 Endoplasmic reticulum aminopeptidase 2 0 15297000.0 5943200.0 3185400.0 6168400.0 False True 7791592.754030676 2710150.7365919515 5530153.139470913 1.0 0.3478301320599644 0.7097590074391535 22.893486842856536 -10.694312045957169 6.9089378412577735 1.003641088318895 0.528794569749774 0.6932536899304358 0.1477568446430625 0.008322979530817317 0.0003682522195233436 0.14368786575518905 0.04768831654922811 2.021566136451967e-11 10.694312045957169 -0.4748465185691211 TQNLAALLHAIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQNLAALLHAIAR 13 0 Q6P179-3;Q6P179;H0Y9X9 Q6P179-3 ERAP2 Endoplasmic reticulum aminopeptidase 2 0 21911200.0 10664000.0 4788600.0 6458600.0 False True 10325477.157178488 6700712.952219113 4766898.906153205 1.0 0.6489494722828026 0.4616637888583345 23.299705116692966 -11.884288686622797 0.09811935420307182 2.220640871050159 6.207593450516447e-19 0.9998697562698315 0.0025465509555062673 5.323420855207997 0.07033053918816258 1.7042219736855206 0.3375241599937436 1.3053029315250052e-12 11.884288686622797 -2.220640871050159 TQNLAALLHAIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQNLAALLHAIAR 13 0 Q6P179-3;Q6P179;H0Y9X9 Q6P179-3 ERAP2 Endoplasmic reticulum aminopeptidase 2 0 30643200.0 5943200.0 12707000.0 11993000.0 False True 8140561.648940981 12145562.723570254 9160500.40358821 1.0 1.4919809280174532 1.125290956402242 22.956696904379427 -10.609268460905325 11.04407389322256 0.9999850660814606 1.308635942209847 0.48574721742120586 0.14970055404215243 5.5049760022132375e-05 1.9474679737980776e-06 0.14495393072923854 0.04831564606027329 2.4588471878523208e-11 10.609268460905325 0.3086508761283864 TQNLAALLHAIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQNLAALLHAIAR 13 0 Q6P179-3;Q6P179;H0Y9X9 Q6P179-3 ERAP2 Endoplasmic reticulum aminopeptidase 2 0 18824200.0 10664000.0 4569600.0 3590600.0 False True 8867588.495301664 4544982.657805421 4341377.858941357 1.0 0.5125387426596871 0.4895781825286051 23.080110392127242 TQNVLGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQNVLGEK 8 0 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 0 21817800.0 4075100.0 10860000.0 6882700.0 False True 5342495.5633245325 9239730.331948452 6170544.227520335 1.0 1.7294783350645864 1.1549928594943977 22.349082374123654 -10.090656329576982 4.176733618699297 0.9999317876266691 1.4422355972879166 0.4413753745996485 0.23453271363584954 164393385.98210934 202423497.22269794 140810.16178843402 0.08583018721823173 8.116030499668491e-11 10.090656329576982 0.4423038096612475 TQNVLGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQNVLGEK 8 0 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 0 14624100.0 4815000.0 3475600.0 6333500.0 False True 4662150.460597748 4863425.205014562 4674566.3490727525 1.0 1.0431720825224093 1.0026631247918611 22.152564134334813 -6.631142330245694 2.0761251254810884 1.028418567019462 1.0028262686753275 0.12166289108611794 0.018513145688094267 0.5560539965244923 4.568863461005718 0.007289186846003739 0.020509382528613916 2.3380708629615577e-07 6.631142330245694 -0.025592298344134568 TQNVLGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQNVLGEK 8 0 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 0 23914600.0 3580600.0 16046000.0 4288000.0 False True 5432031.976923619 13182465.932029786 3440474.9205028336 1.0 2.426801975399186 0.6333679431782937 22.37306054169278 -6.694738121292714 1.8494499508057773 1.890504911889999 0.6391666539786928 0.392741304888068 0.6028683978390887 0.40656700076362795 2.6997164208458 0.2604152526171987 0.6741496768473653 2.0195838015968367e-07 6.694738121292714 -1.2513382579113062 TQNVLGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQNVLGEK 8 0 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 0 15036900.0 4075100.0 5264400.0 5697400.0 False True 5581774.595436692 5031801.400957199 4351791.461636241 1.0 0.9014698309514116 0.7796429947554657 22.412292435646545 -6.968269098322127 0.2966303259512763 1.0219930674371165 0.6553206035118605 0.9999655542198669 0.000528933300493129 0.07686842763807614 0.011029783524542612 0.002055705412673936 0.010965769952289584 1.0757984189341838e-07 6.968269098322127 -0.366672463925256 TQNVLGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQNVLGEK 8 0 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 0 10453100.0 4815000.0 4066600.0 1571500.0 False True 4003885.840667431 4044692.418643095 1900093.3842049665 1.0 1.0101917436209575 0.47456232765323525 21.93296940976909 -6.902563541362027 0.9449159004255882 1.0207303242222683 0.4153171394401269 0.9877991942504303 0.02762873060612991 0.10954294383627963 0.16696731486519376 0.02181931734997681 0.05753651732345342 1.251516151067438e-07 6.902563541362027 -0.6054131847821413 down TQNVLGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQNVLGEK 8 0 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 0 8274200.0 3580600.0 1823100.0 2870500.0 False True 4635157.284177892 1721642.8823663017 2348098.4538172344 1.0 0.37143138340593734 0.5065844177138212 22.14418686378523 -9.92314557242486 6.944688531267396 1.0000000186439568 0.4390079005611572 0.9582848323630064 0.055175995207207534 1.5884435829892066e-08 2.521888450746694e-09 0.05342393002521017 0.01780797587899309 1.1935879552017677e-10 9.92314557242486 -0.5609921180827997 TQNVLGEK(ub)GR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQNVLGEKGR 10 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 290053900.0 67260000.0 54387900.0 168406000.0 True False 88178511.34676655 46273437.32237379 150980962.58442032 1.0 0.5247699991259901 1.712219454359803 26.393923785406905 -6.7980968909103 1.4637158019518122 0.7371584968970443 1.727843065113243 0.8265279051132515 0.20324433727414531 0.22348558804023483 0.9454814985787728 0.10924822258418666 0.2543661906812674 1.5918535455975417e-07 6.7980968909103 0.9906845682161988 TQNVLGEK(ub)GR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQNVLGEKGR 10 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 344327000.0 100843000.0 99187000.0 144297000.0 True False 97641794.16366737 138792886.35337204 106501286.88279013 1.0 1.4214495702601198 1.090734636689208 26.540995469031998 -9.904501111324432 5.3303578387010555 0.9999996293234661 1.2560921034767683 0.4442929401785648 0.13501380626856785 5.947498900821245e-07 1.224259910490705e-07 0.13072674474464838 0.04357551859778833 1.2459450489941209e-10 9.904501111324432 0.25609247415330216 TQNVLGEK(ub)GR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQNVLGEKGR 10 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 572563700.0 115902000.0 84185700.0 372476000.0 True False 175831807.57118952 69162104.08912376 298855955.33796954 1.0 0.3933423937595699 1.699669470877565 27.38962083341636 -6.780423381214664 1.5341972854876045 0.6566852482228029 1.7101598770290791 0.7688948745038845 0.2565947295759561 0.24991623683967804 1.1619176381212541 0.1317255599990776 0.3107102847843627 1.657969812193478e-07 6.780423381214664 1.0534746288062762 TQNVLGEK(ub)GR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQNVLGEKGR 10 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 377165600.0 67260000.0 63326600.0 246579000.0 True False 92127839.63315555 60528621.41893794 188342118.65391272 1.0 0.6570068467898221 2.0443561837971393 26.457133846929796 -6.841290746169009 1.2764085021494647 0.8175584211411021 2.091159579589064 0.9266487889422715 0.1597963688770298 0.1672955127587084 0.5288968650167445 0.09814620925382854 0.22619131253566171 1.4411502248375806e-07 6.841290746169009 1.273601158447962 up TQNVLGEK(ub)GR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQNVLGEKGR 10 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 399008000.0 100843000.0 157375000.0 140790000.0 True False 83855422.60237288 156527189.63850847 170228538.06059006 1.0 1.8666316951347541 2.0300242104530644 26.321400744466274 -10.909497751054348 0.3183208744488467 4.4231113280420614e-17 2.070481960418063 0.9992510805207818 0.012369478843678379 2.698917931260003 0.1600610389558399 2.0630339239490727 0.05453189583188264 1.231692363901702e-11 10.909497751054348 2.070481960418063 TQNVLGEK(ub)GR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQNVLGEKGR 10 1 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 251043000.0 115902000.0 90612000.0 44529000.0 True False 150037423.76997876 85569362.54565047 36425178.9061235 1.0 0.5703201267760782 0.2427739559295997 27.16074715550881 -7.965921675619576 0.2776034105613899 1.142868702672392 9.746701688215993e-23 0.9994336127988527 0.0073793706487607314 0.10367096292788 0.05057660934017778 0.05915691613033971 0.09127736399666404 1.0816290039320224e-08 7.965921675619576 -1.142868702672392 down TQNVLGEK(ub)GRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQNVLGEKGRR 11 2 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 3431260.0 1220200.0 834460.0 1376600.0 True False 1181465.4189037117 1167664.2296514125 1016027.162885223 1.0 0.9883185838269346 0.859971986169515 20.17214597205426 -6.924705153301597 0.7890367061147415 1.0023811757556647 0.8368553533452731 0.9953914128752092 0.004306449803765521 0.09548180380798359 0.09184074617401838 0.0038061327988747166 0.0119689919026796 1.1893093869868437e-07 6.924705153301597 -0.1655258224103916 TQNVLGEK(ub)GRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQNVLGEKGRR 11 2 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 36419300.0 3463900.0 4334400.0 28621000.0 True False 5254989.545010824 3560892.455178233 22964046.804970037 1.0 0.67762122544259 4.36995099767087 22.32525646322123 -6.885630732225838 1.0478467141233239 0.7803341324898706 4.6616592679472575 0.977952596860608 0.24793660868016246 0.12276140323560175 0.24311084032421612 0.18123809789836745 0.44529149399287055 1.301275543952677e-07 6.885630732225838 3.881325135457387 up TQNVLGEK(ub)GRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQNVLGEKGRR 11 2 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 10721200.0 3044800.0 3915800.0 3760600.0 True False 4170544.842626104 3742787.0081810327 2872423.7319881422 1.0 0.8974335846786576 0.688740641901224 21.99180443990251 -6.959706882721053 0.43954530297019234 1.0074974451428258 0.5705462864634305 0.9997591713560079 0.002009808959653262 0.0798059924774224 0.021519459107913985 0.0027499461096217553 0.01729301174744829 1.0972184891996557e-07 6.959706882721053 -0.43695115867939527 TQNVLGEK(ub)GRR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQNVLGEKGRR 11 2 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 3965100.0 1220200.0 1708800.0 1036100.0 True False 1014650.3640254203 1699594.355229756 1252743.7196148676 1.0 1.6750542014166918 1.2346555661251233 19.952551247488536 -10.245863333866442 4.584907756286946 0.9998438594542595 1.4548548837713255 0.5871699567389472 0.17979198999524934 0.00029152541955511683 4.795065085436418e-05 0.17414303357526797 0.05802761525061186 5.677232315148066e-11 10.245863333866442 0.4550110243170661 TQNVLGEK(ub)GRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQNVLGEKGRR 11 2 P23396;P23396-2;E9PL09;E9PPU1;F2Z2S8;H0YCJ7;E9PQ96;E9PJH4;H0YF32;E9PK82 P23396 RPS3 40S ribosomal protein S3 1 43611800.0 3463900.0 3529900.0 36618000.0 True False 4484086.833676989 3333457.9619685174 29953899.732408796 1.0 0.7433972814560894 6.680044531574413 22.09638278531368 -6.896795997157915 0.9812825753817088 0.7310128763852193 7.264228384693761 0.9849043089301129 0.3366590855008637 0.1138029503425139 0.1910102976240643 0.2587790627372562 0.6631150329453581 1.2682474647921374e-07 6.896795997157915 6.533215508308542 up TQPMTAQAASYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQPMTAQAASYR 12 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 7167400.0 1804600.0 2972100.0 2390700.0 False True 2365848.0757712577 2528674.265155059 2143333.297213719 1.0 1.0688236032783807 0.9059471397016905 21.17392600252485 -6.791892787832394 1.4886253131303426 1.038370821415887 0.9041200151039691 0.807443779341415 0.029294849410749682 0.23253852847643597 1.0179316589414962 0.015487698995121996 0.03621328690793444 1.614757134871368e-07 6.791892787832394 -0.134250806311918 TQPMTAQAASYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQPMTAQAASYR 12 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 8870000.0 3255100.0 1690100.0 3924800.0 False True 3151768.632251655 2364965.7437550696 2896777.1385238417 1.0 0.7503614699234805 0.9190957448086394 21.587730201404458 -10.066082813285293 4.780007320182158 1.0000056763177712 0.8347286075740901 0.5612433450424835 0.06888547927350502 4.167167391846426e-06 8.140788536704012e-07 0.06670036919206832 0.022232692833874926 8.588497364406853e-11 10.066082813285293 -0.1652770687436811 TQPMTAQAASYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQPMTAQAASYR 12 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 7972000.0 1804600.0 3240100.0 2927300.0 False True 2471809.387481302 3096941.6684221285 2235932.0296359304 1.0 1.2529047280534107 0.9045729986138925 21.237136064047743 -6.711958205951322 1.7880028102942864 1.155165503421176 0.9053349863252258 0.47450315141304944 0.10654039133118597 0.3711511318676969 2.3141236882947585 0.04739451972801618 0.12012930809409629 1.9410726664779618e-07 6.711958205951322 -0.24983051709595028 TQPMTAQAASYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQPMTAQAASYR 12 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 6741920.0 3255100.0 2562500.0 924320.0 False True 2706759.8753803833 2548695.303883577 1117591.0384271927 1.0 0.9416037702736402 0.4128888744776951 21.368135476838734 -6.927869512840699 0.7640784857534848 1.0087075802983139 0.31000996924375557 0.9961026829032056 0.016486179443207426 0.09375928990524304 0.08321131976656589 0.014833576187447507 0.048412138894014016 1.1806753254608412e-07 6.927869512840699 -0.6986976110545583 down TQPTEDNK(ub)FK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQPTEDNKFK 10 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 3248850.0 1019200.0 1296500.0 933150.0 True False 847509.9582156272 1289515.4971649 1128267.3506018852 1.0 1.5215343308530374 1.3312732666615186 19.692870794407206 -10.077061595661641 4.359757098135485 0.9999602899485927 1.4264037988028297 0.8700794391511434 0.07767375435216586 54371298.99997313 71543298.30962107 27906.999745938174 0.028425680857408462 8.37410504398306e-11 10.077061595661641 0.4264435088542371 TQQIK(ub)SHEYNER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQQIKSHEYNER 12 1 P49454 P49454 CENPF Centromere protein F 1 2312410.0 485930.0 822480.0 1004000.0 True False 404072.32534901804 818049.1369905028 1213931.7580284986 1.0 2.024511667023748 3.004243750125583 18.624254020095886 -6.971668768562672 0.21461728449297052 0.5163262732988071 4.539922992182999 0.9999926377502324 0.0022203162991699435 0.07576486654237956 0.007059306805110549 0.02829101648786315 0.10046702028729963 1.0674099121957285e-07 6.971668768562672 4.023596718884192 TQQIK(ub)SHEYNER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQQIKSHEYNER 12 1 P49454 P49454 CENPF Centromere protein F 1 7116840.0 619440.0 2029800.0 4467600.0 True False 801877.2909878672 1916839.8456624001 3654542.6414470924 1.0 2.3904403668807763 4.55748364808399 19.613021956468735 -6.964613235864264 0.36462878654072234 0.82286732113005 6.19985622936047 0.9999049500520055 0.014271364442334209 0.07809245061715397 0.015324177921551958 0.028818327167318702 0.18459330351143743 1.0848926430381123e-07 6.964613235864264 5.37698890823042 TQQMLHGLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQQMLHGLQR 10 0 O60216;E5RI01;E5RFZ5 O60216 RAD21 Double-strand-break repair protein rad21 homolog 0 2742720.0 689510.0 1236300.0 816910.0 False True 903954.2872243382 1051848.8590596553 732383.9895540461 1.0 1.163608463310063 0.810200250062299 19.785890292141154 -6.780841863741332 1.5327714860313553 1.0925384297746734 0.8073354656134285 0.7702957862294788 0.0692122043095077 0.2492700856701111 1.156817846072821 0.03556435551113229 0.08385173900818181 1.656372975836289e-07 6.780841863741332 -0.2852029641612449 TQRPADVIFATVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQRPADVIFATVR 13 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 31551700.0 8232700.0 10739000.0 12580000.0 False True 10793149.425580202 9136783.060294136 11278342.275880946 1.0 0.8465353994488013 1.0449537786580456 23.36361256682105 -6.7001451321127625 1.8299486072856084 0.9047221221194379 1.044373588203426 0.4184876750323201 0.06477707005888858 0.39520103171478377 2.5729151222770272 0.02823647949446348 0.07261465144493781 1.9945956515238676e-07 6.7001451321127625 0.13965146608398804 TQRPADVIFATVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQRPADVIFATVR 13 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 18536400.0 5090700.0 4430700.0 9015000.0 False True 4929098.515008293 6199901.615795259 6653701.055797102 1.0 1.2578165351975783 1.3498819379522804 22.232892384923215 -13.273420278259062 0.15148240525740336 1.6835308693676107e-09 1.4529617766012224 0.9995648947155282 0.0030889280119171477 9.196007317186245 0.11661642507403917 2.795364716323837 0.0895468679176007 5.328190228523536e-14 13.273420278259062 1.4529617749176915 TQRPADVIFATVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQRPADVIFATVR 13 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 25603700.0 8232700.0 7778700.0 9592300.0 False True 11276551.670352053 7435011.313278969 7326796.299619711 1.0 0.6593337689239577 0.6497373056767956 23.426822628343942 TQRPADVIFATVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQRPADVIFATVR 13 1 P33993;P33993-3 P33993 MCM7 DNA replication licensing factor MCM7 0 13039100.0 5090700.0 3954400.0 3994000.0 False True 4233142.606248322 3933096.862313058 4829126.933830499 1.0 0.9291198592052199 1.1407900425330522 22.01329766035749 -6.816401217683571 1.3872887478171443 0.9616508463395297 1.1450668201317944 0.8759183076333591 0.030987993445012525 0.198203569667383 0.7504774098610044 0.017556880648062274 0.040511365424839595 1.5261554865541297e-07 6.816401217683571 0.1834159737922647 TQSQLAVQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQSQLAVQIR 10 0 A0A0C4DG44;O43464-3;O43464;O43464-2 A0A0C4DG44 HTRA2 Serine protease HTRA2, mitochondrial 0 5546900.0 2143800.0 1282000.0 2121100.0 False True 2810542.5605887314 1090730.5971968593 1901628.9190279068 1.0 0.3880854225414687 0.6766056297078696 21.422417231412023 -10.477589245829124 6.237245724169308 1.00025794128005 0.5323455261247058 0.777924361136685 0.11778788133996282 0.0004227169611895735 3.540526477711416e-05 0.1141089553024812 0.03801587523456094 3.329743303462042e-11 10.477589245829124 -0.4679124151553443 TQSQLAVQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQSQLAVQIR 10 0 A0A0C4DG44;O43464-3;O43464;O43464-2 A0A0C4DG44 HTRA2 Serine protease HTRA2, mitochondrial 0 8412700.0 1815900.0 3059500.0 3537300.0 False True 2754853.0600725054 2513508.3210173924 2838151.104546332 1.0 0.9123928812926374 1.0302368375580926 21.393543938879876 -6.7076657968996365 1.8037911039815302 0.9460117303470225 1.0299380198620969 0.45386731628450006 0.03693107037475519 0.3797974434125969 2.407429292829147 0.016303131829461977 0.041531152247585607 1.9603526454983704e-07 6.7076657968996365 0.08392628951507441 TQSSASLAASYAAQQHPQAAASYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQSSASLAASYAAQQHPQAAASYR 24 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 69647000.0 23059000.0 21998000.0 24590000.0 False True 30230572.303673662 18715984.147532396 22045662.683935784 1.0 0.6191078342654467 0.7292505898492951 24.849504955511144 -10.375460450481848 8.557692812618356 1.0000014735374418 0.6741792120573719 0.9210589341270807 0.04496559167408523 1.26415205271356e-06 9.226221404985184e-08 0.0435379434654544 0.014512582308841249 4.212496465828706e-11 10.375460450481848 -0.32582226148007 TQSSASLAASYAAQQHPQAAASYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQSSASLAASYAAQQHPQAAASYR 24 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 47127000.0 13463000.0 10145000.0 23519000.0 False True 13035624.43427362 14195951.405476112 17358668.345123876 1.0 1.089011997626422 1.3316330516153865 23.635956356916445 -6.9535840663767035 0.5180049076408476 0.9958127491754708 1.4356228131680322 0.9994533581265633 0.003276665220822808 0.08207770802447828 0.03024734973749138 0.0037239430641385265 0.020036822883853223 1.112796967859274e-07 6.9535840663767035 0.4398100639925614 TQSSASLAASYAAQQHPQAAASYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQSSASLAASYAAQQHPQAAASYR 24 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 91261000.0 26255000.0 47088000.0 17918000.0 False True 39830754.49760651 38684778.49977673 14376499.446261603 1.0 0.9712288654261209 0.36093967155770323 25.247379472551486 -6.916735650103251 0.8485880274428885 1.0151142226842638 0.2695540771961873 0.9932249364948094 0.024257697721860122 0.1001309119327248 0.1158495730671766 0.020546895754691697 0.05975125106369303 1.211335234576062e-07 6.916735650103251 -0.7455601454880765 down TQSSASLAASYAAQQHPQAAASYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQSSASLAASYAAQQHPQAAASYR 24 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 61296000.0 23059000.0 21106000.0 17131000.0 False True 31584535.446044225 20173467.13179144 13085010.624019805 1.0 0.6387134351320036 0.4142853595669594 24.912715017034035 -8.799558790874544 0.14482808800613076 1.4796909113374035 2.5646502896018065e-10 0.9998838616367205 0.002600240932445077 0.32280295042937296 0.04230700186334908 0.23048926212715945 0.16474920814704577 1.586504137776455e-09 8.799558790874544 -1.4796909110809384 TQSSASLAASYAAQQHPQAAASYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQSSASLAASYAAQQHPQAAASYR 24 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 29213200.0 13463000.0 9941100.0 5809100.0 False True 11195081.012026088 9887545.321146147 7023755.95175633 1.0 0.8832044458208612 0.6273966168008256 23.41636163235072 -6.958230295177148 0.45970379737255296 1.0074784420281238 0.4928157763531002 0.9996988014363504 0.002700504480780899 0.08033957351697889 0.023514480558782705 0.003472412205726187 0.02113296031105672 1.1009553464631097e-07 6.958230295177148 -0.5146626656750235 TQSSASLAASYAAQQHPQAAASYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQSSASLAASYAAQQHPQAAASYR 24 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 65443000.0 26255000.0 20141000.0 19047000.0 False True 33987615.063422546 19020135.644638088 15580641.438723883 1.0 0.5596196028802135 0.4584211457511698 25.018505794643936 -13.999999999999998 0.20661140251256493 3.5120748028278386 0.3968198455267666 0.9994883905937424 0.005317863281227176 12.66952341775222 0.14409462908113485 12.899292952707857 0.06140055936855711 1.0000000000000041e-14 13.999999999999998 -3.115254957301072 TQTFYK(ub)ELNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQTFYKELNR 10 1 B4DVT3;B4DJL6;Q96SY0-4;Q96SY0-3;Q96SY0;H3BRY6 B4DVT3 VWA9 von Willebrand factor A domain-containing protein 9 1 4469600.0 0.0 3010100.0 1459500.0 True False 0.0 2993883.993841933 1764674.7020344543 0.0 TQTVCNFTDGALVQHQEWDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQTVCNFTDGALVQHQEWDGK 21 0 Q01469;I6L8B7;A8MUU1 Q01469 FABP5;FABP5P3 Fatty acid-binding protein, epidermal;Putative fatty acid-binding protein 5-like protein 3 0 23276700.0 4310400.0 9449000.0 9517300.0 False True 5650976.141972983 8039246.031913523 8532541.092388045 1.0 1.4226296183063867 1.5099233969529717 22.4300686675679 -12.022325601304434 0.25778495309006755 3.3269363841532843e-09 1.5456275377253186 0.9993887256866764 0.005505408174510876 5.243137692786326 0.1488890703845297 2.832918586671651 0.0385486579102854 9.498923688477877e-13 12.022325601304434 1.5456275343983823 TQTVTISDNANAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQTVTISDNANAVK 14 0 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;A0A2R8Y783 P11171 EPB41 Protein 4.1 0 4675700.0 1073900.0 2316800.0 1285000.0 False True 1407893.299662394 1971142.470815669 1152040.5265903813 1.0 1.4000652402340004 0.8182726111890972 20.425106569577103 -6.721649803372316 1.7532001820184404 1.2429656564572382 0.819084507736741 0.5203301100085793 0.16831623158834008 0.3521435502211743 2.1161755069435695 0.07620022195895469 0.19093378317392068 1.8982359611181847e-07 6.721649803372316 -0.4238811487204972 TQTVTISDNANAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQTVTISDNANAVK 14 0 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;A0A2R8Y783 P11171 EPB41 Protein 4.1 0 6909400.0 2626100.0 2163600.0 2119700.0 False True 3399538.218170017 2043193.7580427476 1733936.349958678 1.0 0.6010209701782985 0.5100505535401987 21.696907358157173 -13.999999999999964 0.20771759799187353 3.2860672196667338 0.45526832050972926 0.9994888571019112 0.0048108178779051845 12.694224117248295 0.14447234953970267 11.830706925897235 0.05476111149573963 1.0000000000000819e-14 13.999999999999964 -2.8307988991570046 TQTVTISDNANAVK(ub)SEIPTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQTVTISDNANAVKSEIPTK 20 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;A0A2R8Y783 P11171 EPB41 Protein 4.1 1 16935500.0 3438500.0 7146400.0 6350600.0 True False 4451206.032968129 6748696.557809514 5194855.96265868 1.0 1.5161501192766367 1.1670670654610598 22.08576484968345 -10.484926182285344 5.7252872930766765 0.9996157771394018 1.3416085923688483 0.5607960872732434 0.14251255995011478 0.0006997007943994787 6.294852692952404e-05 0.13813883102059543 0.04599573094268157 3.273963382192231e-11 10.484926182285344 0.3419928152294466 TQVAGGQLSFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQVAGGQLSFK 11 0 P46060;B0QYT5;B0QYT4;B0QYT6 P46060 RANGAP1 Ran GTPase-activating protein 1 0 60983000.0 14885000.0 18718000.0 27380000.0 False True 19514379.146545064 15925347.362192519 24546980.247505583 1.0 0.8160827071463369 1.257891940254298 24.21803422811836 -6.793624399273192 1.4816506615659548 0.897691026833954 1.2630829153125167 0.8129067460036218 0.07838049894642882 0.22998801990851972 0.9972762016965215 0.04162942184360292 0.0972209385625241 1.608331621534255e-07 6.793624399273192 0.36539188847856274 TQVAGGQLSFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQVAGGQLSFK 11 0 P46060;B0QYT5;B0QYT4;B0QYT6 P46060 RANGAP1 Ran GTPase-activating protein 1 0 34426900.0 8761600.0 4637300.0 21028000.0 False True 8483467.803857373 6488998.073200037 15520135.97352205 1.0 0.764899239701191 1.829456577470024 23.01622268797453 -6.848782471158898 1.2408341339386662 0.8746517619882598 1.8710508782603155 0.9385274620905436 0.1132138926598348 0.15880482093603107 0.4711087522744978 0.07141414447211902 0.16514492057070654 1.4165030984845063e-07 6.848782471158898 0.9963991162720557 TQVAGGQLSFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQVAGGQLSFK 11 0 P46060;B0QYT5;B0QYT4;B0QYT6 P46060 RANGAP1 Ran GTPase-activating protein 1 0 48416300.0 10974000.0 28103000.0 9339300.0 False True 16648360.306864714 23087800.08025882 7493383.261439402 1.0 1.3867912307699692 0.45009737435521574 23.988876757805755 -6.794562748403722 1.4779039376389258 1.2149079182133 0.4388253020839391 0.8157900528854609 0.16495383788892298 0.22862960855396247 0.9863321199000752 0.08782793762350094 0.20497813519223784 1.604860365439727e-07 6.794562748403722 -0.7760826161293609 down TQVAGGQLSFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQVAGGQLSFK 11 0 P46060;B0QYT5;B0QYT4;B0QYT6 P46060 RANGAP1 Ran GTPase-activating protein 1 0 36417300.0 14885000.0 8334300.0 13198000.0 False True 20388386.752000023 7966063.068155471 10080904.221342213 1.0 0.39071571307004127 0.49444344684864855 24.28124428964125 -10.228805280544682 6.4309652765631435 1.0000061186608264 0.4425795799593446 0.9746866104631803 0.042346669988808185 3.714993984190501e-06 4.4549066080919325e-07 0.04100243624874762 0.013667328969499468 5.904657609471512e-11 10.228805280544682 -0.5574265387014818 TQVAGGQLSFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQVAGGQLSFK 11 0 P46060;B0QYT5;B0QYT4;B0QYT6 P46060 RANGAP1 Ran GTPase-activating protein 1 0 22492600.0 8761600.0 9253700.0 4477300.0 False True 7285658.604691959 9203848.481384356 5413482.729303787 1.0 1.2632829756059505 0.7430327198995447 22.796627963408806 -6.769081041976203 1.5776627832699637 1.151182008562472 0.7401842037024703 0.7271982345345573 0.11093559881078635 0.2678892638283874 1.3157285387553095 0.05542672154301609 0.13206670938567325 1.7018409049597857e-07 6.769081041976203 -0.4109978048600017 TQVAGGQLSFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQVAGGQLSFK 11 0 P46060;B0QYT5;B0QYT4;B0QYT6 P46060 RANGAP1 Ran GTPase-activating protein 1 0 38564400.0 10974000.0 18817000.0 8773400.0 False True 14206059.329879962 17769817.408527628 7176731.222685985 1.0 1.250861832679519 0.5051880367408424 23.760003079898205 -6.815948456688371 1.3891634885396973 1.135791365130392 0.4902608648080972 0.874853418448706 0.10959603114143868 0.19879116420319895 0.7548373954548757 0.06201141843288595 0.14311379178360004 1.527747364907015e-07 6.815948456688371 -0.6455305003222946 TQVTVQYMQDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TQVTVQYMQDR 11 0 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 127749000.0 40742000.0 29120000.0 57887000.0 False True 53413156.54608918 24775409.508870985 51897408.53131321 1.0 0.4638446987774026 0.9716221973612801 25.67069180960663 -10.697579463985777 9.894317114417046 1.0002873523365454 0.7177334480693414 0.291791103689648 0.2072992957328846 0.0013152970363652064 4.0202102640304654e-05 0.20091240846040573 0.06690556000449902 2.0064139376768627e-11 10.697579463985777 -0.28255390426720406 TQVTVQYMQDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQVTVQYMQDR 11 0 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 81648000.0 23425000.0 10564000.0 47659000.0 False True 22681386.197196696 14782260.290532222 35175678.16064714 1.0 0.6517353111495114 1.5508610388634303 24.4350054790379 -6.801668712640273 1.4489728398245034 0.8082484147166008 1.5638071309991486 0.8370241522602446 0.149434424906683 0.21838623389345108 0.9050056081336251 0.08112422445128198 0.18848644757257538 1.5788151580404216e-07 6.801668712640273 0.7555587162825478 TQVTVQYMQDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQVTVQYMQDR 11 0 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 116234000.0 33565000.0 48596000.0 34073000.0 False True 50920558.93019083 39923664.11771902 27338456.61527361 1.0 0.7840382147503933 0.5368844566838528 25.60174491929898 -6.969363633989578 0.27296117888585264 1.0592765147356968 0.2541864455427427 0.9999769826175152 0.0009077390517814552 0.07650978272251499 0.00976696446419565 0.004758475311801624 0.022894370635644222 1.073090539300396e-07 6.969363633989578 -0.8050900691929541 TQVTVQYMQDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQVTVQYMQDR 11 0 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 111408000.0 40742000.0 31784000.0 38882000.0 False True 55805418.411151044 30379677.784367435 29698872.39992636 1.0 0.5443858078536862 0.5321861791469326 25.73390187112952 TQVTVQYMQDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TQVTVQYMQDR 11 0 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 56067000.0 23425000.0 19229000.0 13413000.0 False True 19478925.40345471 19125409.56034233 16217596.285295064 1.0 0.9818513682972634 0.8325714047048391 24.215410754472178 -6.9295821560177755 0.7502120060599294 1.002305637247913 0.8022483695076249 0.9964555074315657 0.004466104857003915 0.09285539649218878 0.07874680225789242 0.004058767982839918 0.01353843400511901 1.1760284928939576e-07 6.9295821560177755 -0.2000572677402882 TQVTVQYMQDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQVTVQYMQDR 11 0 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 125908000.0 33565000.0 60219000.0 32124000.0 False True 43450554.16506478 56867759.71324465 26277761.620074823 1.0 1.3087925069311912 0.604773911979303 25.37287124139143 -6.787507578244657 1.5064745029516025 1.1731481741745393 0.5978132585426751 0.7930695260663061 0.13107172403325168 0.23909772597098877 1.0720347479838503 0.06849636213540661 0.160649176998088 1.631144446237749e-07 6.787507578244657 -0.5753349156318642 TQYEELK(ub)AQQDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TQYEELKAQQDK 12 1 P12270 P12270 TPR Nucleoprotein TPR 1 11140300.0 2442900.0 3571800.0 5125600.0 True False 3706057.8999125054 2934384.383399223 4112522.913369716 1.0 0.7917805017208446 1.1096758400527975 21.821453990156197 -6.730002366208449 1.723394243360881 0.8746951773915205 1.1094812723571508 0.5592364007775784 0.08753016021645263 0.3362157228559408 1.9563667243339713 0.04025019435775841 0.09987126855827451 1.862076991301836e-07 6.730002366208449 0.2347860949656303 TQYEELK(ub)AQQDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TQYEELKAQQDK 12 1 P12270 P12270 TPR Nucleoprotein TPR 1 17727300.0 2442900.0 4476500.0 10807900.0 True False 3162382.2067581355 4227378.839840249 8840973.098418834 1.0 1.3367703722864914 2.795668746024856 21.592580312248646 -6.943046878992922 0.6305798193595312 0.9840854497060519 3.227058702379046 0.9985363809672095 0.029815116671410097 0.08640369134870222 0.04848310564166018 0.029742720807816342 0.12397786724452771 1.1401267123689316e-07 6.943046878992922 2.242973252672994 up TQYSSAMLESLLPGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TQYSSAMLESLLPGIR 16 0 E9PLK3;P55786;P55786-2;H0YCQ5 E9PLK3 NPEPPS Puromycin-sensitive aminopeptidase 0 4400500.0 0.0 1413300.0 2987200.0 False True 0.0 1977638.0602621355 2204762.705920917 0.0 TQYSSAMLESLLPGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TQYSSAMLESLLPGIR 16 0 E9PLK3;P55786;P55786-2;H0YCQ5 E9PLK3 NPEPPS Puromycin-sensitive aminopeptidase 0 4306150.0 661550.0 1307600.0 2337000.0 False True 906142.9127165332 1249825.908345042 1785048.732025819 1.0 1.3792812268411159 1.9699417243957764 19.789379077917733 -6.964626786517519 0.36440510949424815 0.9515966853004513 2.4180067318083194 0.9999052385701381 0.0038850454269854983 0.07808788555301766 0.015308193766499749 0.007858027542589624 0.050320092704154024 1.0848587932534793e-07 6.964626786517519 1.466410046507868 TREDNDLDSQVSQEGLGPVLQPQPK(ub)SYFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TREDNDLDSQVSQEGLGPVLQPQPKSYFK 29 2 O00165-5;O00165-3;O00165;O00165-2;E9PIQ7 O00165-5 HAX1 HCLS1-associated protein X-1 1 267782000.0 28773000.0 212967000.0 26042000.0 True False 43650744.58806436 174961374.9312344 20894787.285385918 1.0 4.008210549037804 0.4786811194762365 25.379502927558715 -6.681015454048814 1.8985583757352145 2.9016886600961604 0.49214980735215896 0.3285428599953871 1.2746873943648882 0.43634240964603616 3.0418161130759542 0.5385955348862411 1.4185192895802634 2.084416709346398e-07 6.681015454048814 -2.4095388527440016 TREDNDLDSQVSQEGLGPVLQPQPK(ub)SYFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TREDNDLDSQVSQEGLGPVLQPQPKSYFK 29 2 O00165-5;O00165-3;O00165;O00165-2;E9PIQ7 O00165-5 HAX1 HCLS1-associated protein X-1 1 454231000.0 28773000.0 185311000.0 240147000.0 True False 37247215.70062292 174998279.9485392 196442710.11630285 1.0 4.698291581177503 5.274024015519032 25.150629249651164 -9.73112209385315 0.4929922984695738 3.744550295125e-20 5.268063476825476 0.998819146249046 0.06507548177457541 1.0242675105411319 0.21825870936013728 1.840965522020209 0.11785016386612861 1.8572822411729783e-10 9.73112209385315 5.268063476825476 TREEECHFYAGGQVYPGEASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TREEECHFYAGGQVYPGEASR 21 1 Q13162;A6NG45 Q13162 PRDX4 Peroxiredoxin-4 0 69225100.0 13785200.0 29571900.0 25868000.0 False True 18072530.696066715 25159887.79036339 23191427.503377452 1.0 1.3921618512364269 1.2832418377590478 24.10729520511395 -10.379451418103617 5.083495340444606 0.9997634202284644 1.337701844497769 0.9276259822560311 0.044466409299551535 0.00011930939598609245 1.4564222614651515e-05 0.043084243168115724 0.014351471890217954 4.1739628745145817e-11 10.379451418103617 0.33793842426930465 TREEECHFYAGGQVYPGEASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TREEECHFYAGGQVYPGEASR 21 1 Q13162;A6NG45 Q13162 PRDX4 Peroxiredoxin-4 0 13003900.0 5976400.0 2012600.0 5014900.0 False True 5786682.453315959 2816241.675570351 3701347.2462248285 1.0 0.48667638120639434 0.639631995722149 22.464305047094705 -10.789599744930342 10.633619382118548 1.0025293675685651 0.563154188464287 0.9157956837526533 0.06244386814290648 0.0037517163447488007 7.423246310686833e-05 0.06057876212226593 0.020153671782520734 1.6233054811642917e-11 10.789599744930342 -0.43937517910427815 TREEECHFYAGGQVYPGEASR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TREEECHFYAGGQVYPGEASR 21 1 Q13162;A6NG45 Q13162 PRDX4 Peroxiredoxin-4 0 83682000.0 13427000.0 58071000.0 12184000.0 False True 20369740.645186163 47707776.33920607 9775827.059563104 1.0 2.342090514072427 0.47991907358296954 24.279924275723694 -6.713297280728848 1.7833079254730881 1.822271608346087 0.48382161595088696 0.4808593400388157 0.5652643493735062 0.36846242585043715 2.2861248450943106 0.2520488116222146 0.6378096374059539 1.9350969092252328e-07 6.713297280728848 -1.3384499923952 TREEECHFYAGGQVYPGEASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TREEECHFYAGGQVYPGEASR 21 1 Q13162;A6NG45 Q13162 PRDX4 Peroxiredoxin-4 0 48549200.0 13785200.0 14923600.0 19840400.0 False True 18881960.971022554 14264226.006254278 15154506.145864354 1.0 0.7554419812722343 0.8025917524732422 24.17050526663684 -10.551105541597241 6.31793673292515 1.000322308930317 0.7790168668727391 0.9669842160896204 0.019248813488573772 8.75138430398569e-05 6.217902471311321e-06 0.018664356578676225 0.006212527839624898 2.8112175694789776e-11 10.551105541597241 -0.22130544205757796 TREEECHFYAGGQVYPGEASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TREEECHFYAGGQVYPGEASR 21 1 Q13162;A6NG45 Q13162 PRDX4 Peroxiredoxin-4 0 11563600.0 5976400.0 1633000.0 3954200.0 False True 4969641.399411174 1624202.704874879 4781004.93784491 1.0 0.32682493048036065 0.9620422387843488 22.24471032252898 -10.878397881228604 10.505338343634454 1.0187693543033343 0.6444335846323598 0.29466616669291035 0.2593263801881598 0.09951844190384539 0.0011519505226507622 0.21919353016924123 0.08369722930841633 1.323128788181781e-11 10.878397881228604 -0.3743357696709745 TREEECHFYAGGQVYPGEASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TREEECHFYAGGQVYPGEASR 21 1 Q13162;A6NG45 Q13162 PRDX4 Peroxiredoxin-4 0 45784000.0 13427000.0 14523000.0 17834000.0 False True 17381516.18573889 13714782.283256982 14588394.992292814 1.0 0.7890440705345155 0.8393050891764111 24.051050597816143 -10.82638101240653 7.1595506650221195 1.0106186956250451 0.8141745798561143 0.9479865343354774 0.020518974937526222 0.00356781686020258 8.651937857854577e-05 0.020381183217918476 0.006622470684523867 1.49148533522763e-11 10.82638101240653 -0.19644411576893084 TREGNDLYHEMIESGVINLK(ub)DATSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TREGNDLYHEMIESGVINLKDATSK 25 2 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 1 25386900.0 4088600.0 6921300.0 14377000.0 True False 6202705.116698298 5686139.938636281 11535379.648337051 1.0 0.9167193718960825 1.8597336857563427 22.564466108583435 -6.885373836275388 1.0493959402627029 0.9435698606479269 1.9338455534407535 0.9777669646548474 0.06356001157648015 0.12297546821069096 0.2444348672021579 0.046408582606815484 0.11392565549955729 1.3020455083943594e-07 6.885373836275388 0.9902756927928266 TRLELEENQMK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TRLELEENQMKR 12 2 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 14245800.0 6096500.0 2305100.0 5844200.0 True False 5902969.944555379 3225538.4509376953 4313428.697758108 1.0 0.546426372018509 0.730721778744039 22.493009565530915 -10.171023046892488 5.344723834413982 1.000013408074713 0.6385740753811692 0.8368147146406543 0.07523828473640762 1.2021177429644962e-05 1.864433687220687e-06 0.07285185588503935 0.024283051981723414 6.744922331780687e-11 10.171023046892488 -0.3614393326935438 TRNEELAQTWK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 TRNEELAQTWKR 12 2 Q8TAT6;Q8TAT6-2;I3L283;I3L3I1;I3L281 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 102353900.0 4610900.0 40175000.0 57568000.0 True False 6995072.401943013 33005457.36129232 46189659.567049265 1.0 4.718386810710413 6.60317104855401 22.737907559292267 -8.67726109424743 0.33501603012032344 2.339455468420137e-22 7.316979255133611 0.9981693931013612 0.09960289996374054 0.2647254998441351 0.10492729459999944 0.8880058427657115 0.5559113666139709 2.102514045693272e-09 8.67726109424743 7.316979255133611 TRNEELAQTWK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TRNEELAQTWKR 12 2 Q8TAT6;Q8TAT6-2;I3L283;I3L3I1;I3L281 Q8TAT6 NPLOC4 Nuclear protein localization protein 4 homolog 1 84003900.0 4610900.0 34496000.0 44897000.0 True False 5968900.944427156 32576267.27557893 36726206.68212237 1.0 5.457665921897004 6.1529261457105715 22.509033881384717 -9.634282371065819 0.5153323252299769 6.1755818193045865e-24 6.131762762463774 0.9987212533773355 0.0816373671931581 0.9340807522067732 0.22732325653150498 1.8701660149685437 0.13652222487701637 2.321227082282347e-10 9.634282371065819 6.131762762463774 TRPAANPIQFTLNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TRPAANPIQFTLNK 14 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 0 11351500.0 2687000.0 2657300.0 6007200.0 False True 3522683.0209450135 2260841.198074275 5385632.569131315 1.0 0.6417952409092346 1.5288439343278002 21.748243233006125 -6.797099218974864 1.4678183206226656 0.8016305453979713 1.5402175059359513 0.8235224265683978 0.15306600105136972 0.22492359867929704 0.9569989319059008 0.08205140807160559 0.19116068622538646 1.5955145941198697e-07 6.797099218974864 0.73858696053798 TRPAANPIQFTLNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TRPAANPIQFTLNK 14 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 0 11671700.0 1632700.0 1225400.0 8813600.0 False True 1580870.832194797 1714708.61037658 6505053.75766759 1.0 1.0846607929352265 4.114854689700562 20.592288063924432 -6.9128832934937385 0.875886282834526 0.9145171794339155 4.53158120110142 0.9919645655520166 0.1298725485065828 0.1025417335273346 0.12865929509014953 0.10786814102787985 0.30405645108419216 1.2221280344281428e-07 6.9128832934937385 3.6170640216675043 up TRPAANPIQFTLNK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TRPAANPIQFTLNKEK 16 2 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 59168000.0 11688000.0 17160000.0 30320000.0 True False 17731550.507256683 14097663.928308055 24327238.71027194 1.0 0.7950609802870059 1.3719747012713837 24.07981536013938 -6.810657842233413 1.411635091866881 0.8883961938896491 1.3822332135968256 0.8615732013617745 0.08884436347685239 0.2059020813597363 0.8085287796902053 0.0494846857008537 0.11444151029160204 1.5464723438872798e-07 6.810657842233413 0.4938370197071765 TRPAANPIQFTLNK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TRPAANPIQFTLNKEK 16 2 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 58522000.0 11688000.0 22499000.0 24335000.0 True False 15130346.404924097 21246910.871789493 19906279.69818582 1.0 1.4042580588158107 1.315652607378997 23.85094168223183 -10.060385836446754 4.79896165331899 0.9999909599808912 1.3599553330977252 0.9565305848782548 0.03617302411430187 4649106.382097165 9746234.11539411 337.5457868332874 0.012382988745389753 8.701901510149076e-11 10.060385836446754 0.35996437311683405 TRPAANPIQFTLNKEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 TRPAANPIQFTLNKEK 16 2 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 29019000.0 5493000.0 10308000.0 13218000.0 True False 5318627.721716182 14424038.15550986 9755809.268499842 1.0 2.711984916074479 1.834271879693038 22.342622628122484 -10.121366746432242 6.0996817553195815 0.9999944347174818 2.273128397883775 0.7372080671075405 0.3583248466206294 2.7119170491363546e-05 3.906483640831752e-06 0.3469480586692155 0.11564884695782672 7.561940460110785e-11 10.121366746432242 1.2731339631662932 TRPDGNCFYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TRPDGNCFYR 10 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 13275400.0 2853300.0 8052000.0 2370100.0 False True 4328664.704171414 6615057.689436859 1901648.696148265 1.0 1.5281982185088423 0.43931531456240974 22.04549062389076 -6.774794910434338 1.5560378968135 1.301099766203613 0.432039510847362 0.7485841025924121 0.2229288830940936 0.25874477510888594 1.236977631957124 0.1128826956903218 0.2675503218726263 1.6795969973353765e-07 6.774794910434338 -0.869060255356251 down TRPDGNCFYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TRPDGNCFYR 10 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 3800910.0 839310.0 1366100.0 1595500.0 False True 1149625.5884999065 1305741.1849114117 1218675.760353954 1.0 1.1357969046385035 1.0600631827829685 20.132732648263264 -10.06923379078155 4.23500179562695 0.9999890284582906 1.09793004373261 0.6903469334358356 0.030918162547236075 21456154.425271697 0.18099698867918318 2342.8276414125644 0.010584109404645312 8.526409940497307e-11 10.06923379078155 0.09794101527431942 TRPDGNCFYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TRPDGNCFYR 10 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 6720800.0 2853300.0 1922300.0 1945200.0 False True 3693653.096951567 1815322.315162495 1591193.5594374787 1.0 0.4914707113834568 0.4307912837701832 21.81661694598321 -13.999999999999998 0.29993094578457224 5.636802800295838 0.41585039542961716 0.999649676828326 0.004777122303972935 16.58388855648397 0.173925857872998 47.7189604189373 0.021935627791890375 1.0000000000000041e-14 13.999999999999998 -5.220952404866221 TRPGK(ub)CFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TRPGKCFR 8 2 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 1 17339600.0 2327700.0 7829300.0 7182600.0 True False 3051637.241478864 6661198.9583723685 6439413.4523642585 1.0 2.182827915399362 2.1101503693943755 21.541152043611806 -10.443200975835905 5.699533579664182 0.999231090611344 2.1464891423968693 0.9969952041821718 0.02967048391165018 0.00029005975869469855 2.8336523892687798e-05 0.028744635238181375 0.009576107505310547 3.6041181882262417e-11 10.443200975835905 1.1472580517855253 TRPGK(ub)CFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TRPGKCFR 8 2 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 1 8492900.0 2769200.0 3076300.0 2647400.0 True False 2681293.2617834457 4304682.632692572 1953966.5197024106 1.0 1.6054501363380664 0.7287403237655331 21.354497589533345 -6.720872479647727 1.7558553198019267 1.3679923659448272 0.7300072528840968 0.5168084850311281 0.25474786337792216 0.35360831258461956 2.1309776591260374 0.11517063770612743 0.28886011659892363 1.9016365687731732e-07 6.720872479647727 -0.6379851130607304 TRPGK(ub)CFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TRPGKCFR 8 2 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 1 13164000.0 2327700.0 4627100.0 6209200.0 True False 3188313.5937272687 4422659.422226477 4742714.842488106 1.0 1.387146932763351 1.4875308538717733 21.604362105134697 -12.200907403973375 0.21874145891105057 2.1313299318647627e-11 1.546795417679911 0.9993900588271113 0.005191235942843436 5.751100196724721 0.1353085842282512 2.6252490350721653 0.055840845297342824 6.296404143248473e-13 12.200907403973375 1.5467954176585976 TRPGK(ub)CFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TRPGKCFR 8 2 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 1 7258200.0 2769200.0 1473500.0 3015500.0 True False 2302712.496360593 1465561.9630331504 3646027.1079033217 1.0 0.636450258271257 1.5833618455042997 21.13490286496762 -6.802650559741587 1.445266004272036 0.8000836058816178 1.5972742282843324 0.8397435773346507 0.15613755874336085 0.21699865926582346 0.8945919312417869 0.08498266988680453 0.19731020710826416 1.5752498257926594e-07 6.802650559741587 0.7971906224027147 TRPSSDQLK(ub)EASGTDVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TRPSSDQLKEASGTDVK 17 2 Q8N0X7 Q8N0X7 SPG20 Spartin 1 4719800.0 1817200.0 1551500.0 1351100.0 True False 2382366.7977898335 1320022.2476996311 1211301.132666356 1.0 0.5540801898868976 0.5084444317265094 21.18396412216234 -13.999999999999998 0.32212262333650327 5.630316496922111 0.49959740912144773 0.9996982653465314 0.0038518908882206266 18.17958522324523 0.18109774215836047 56.79369654358805 0.015068804017826768 1.0000000000000041e-14 13.999999999999998 -5.130719087800664 TRPSSDQLK(ub)EASGTDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TRPSSDQLKEASGTDVK 17 2 Q8N0X7 Q8N0X7 SPG20 Spartin 1 6503800.0 2205000.0 2531500.0 1767300.0 True False 2135003.4819559776 3542341.1515980996 1304391.112136463 1.0 1.659173477484352 0.6109550280177757 21.025806992048874 -6.7367450757906235 1.6989090631877766 1.3936829767986771 0.6108007814524452 0.5901249966717023 0.27698510496954537 0.32373185645517333 1.833421310656963 0.12905485896325175 0.3177914283357818 1.833390278598737e-07 6.7367450757906235 -0.7828821953462319 TRPSSDQLK(ub)EASGTDVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TRPSSDQLKEASGTDVK 17 2 Q8N0X7 Q8N0X7 SPG20 Spartin 1 47044000.0 14203000.0 19596000.0 13245000.0 True False 21546989.378385246 16098940.695753159 10627119.944510262 1.0 0.7471549928874394 0.4932067194116132 24.360982969150147 -6.97107130031736 0.23117300809283534 1.1017760242721555 0.13131939180575417 0.9999895741509208 0.0006680286120529342 0.07595661657083008 0.007775119224425638 0.006469066226014017 0.025165022247679077 1.0688793814932455e-07 6.97107130031736 -0.9704566324664013 down TRPSSDQLK(ub)EASGTDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TRPSSDQLKEASGTDVK 17 2 Q8N0X7 Q8N0X7 SPG20 Spartin 1 6367700.0 2205000.0 2339500.0 1823200.0 True False 1833555.1980626548 2326896.6491456106 2204422.6904756534 1.0 1.2690627757507509 1.202266881741471 20.80621226748315 -10.08101464345659 4.440669121585166 0.9999821591217611 1.2356648287105287 0.9431720243681769 0.027269309612596365 18946115.22350999 0.173518324374324 3789.367058181005 0.009335009990415288 8.298227872399033e-11 10.08101464345659 0.2356826695887676 TRPSSDQLK(ub)EASGTDVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TRPSSDQLKEASGTDVK 17 2 Q8N0X7 Q8N0X7 SPG20 Spartin 1 37918700.0 14203000.0 16923000.0 6792700.0 True False 18386063.482985713 15981220.173487406 5556498.298987748 1.0 0.8692029258071623 0.3022125048208214 24.132109291242596 -6.943032179675756 0.630726597543702 1.0061851377316697 0.1346346494434547 0.9985346662313839 0.011593211883659969 0.08641023013948806 0.04851241933016473 0.011563566941663531 0.048185918590000036 1.1401653022393394e-07 6.943032179675756 -0.871550488288215 down TRPVVAAGAVGLAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TRPVVAAGAVGLAQR 15 1 B7Z9I1;Q5T4U5;P11310;P11310-2;H0YDT5 B7Z9I1 ACADM Medium-chain specific acyl-CoA dehydrogenase, mitochondrial 0 4945660.0 1177600.0 859260.0 2908800.0 False True 1140217.7325856518 1202366.9989817056 2146898.0178705025 1.0 1.0545064899623329 1.882884256677906 20.120877912773643 -6.9202659457338465 0.8227527880646758 0.9818972225171135 2.0172879058390523 0.994254487356665 0.030619954838418964 0.09801544793099826 0.10480543831795956 0.026419465159680383 0.07934106915624599 1.2015284381147918e-07 6.9202659457338465 1.0353906833219386 TSAALSTVGSAISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSAALSTVGSAISR 14 0 O43399;O43399-5;O43399-7;A0A087WYR3;O43399-2;O43399-4;O43399-3;O43399-6 O43399;O43399-2 TPD52L2 Tumor protein D54 0 6455800.0 3274900.0 3180900.0 0.0 False True 4485719.030844798 3040357.320170344 0.0 1.0 0.6777859467488206 0.0 22.096907827398493 -7.474194066047522 0.7263036783530433 0.9923144587234433 3.14782019852724e-17 0.9871436894814802 0.04725484803691741 0.11782759707325442 0.1413949486247153 0.041502434595091606 0.07498248483639243 3.355876222001138e-08 7.474194066047522 -0.9923144587234433 down TSACGLFSVCYPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSACGLFSVCYPR 13 0 P30153;C9J9C1;P30154;P30154-2;P30154-4;P30154-3 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 0 64976000.0 17895000.0 24071000.0 23010000.0 False True 23460518.29542652 20479700.62802313 20629145.927505594 1.0 0.8729432304151403 0.8793133070520064 24.483731550296707 -10.307199843535635 5.787047682873135 1.0000121256241699 0.8761282687338879 0.9980205352106954 0.00260057289712663 4.068875416156824e-07 4.871126354423139e-08 0.002518240274220655 0.0008393312934304833 4.929469189074001e-11 10.307199843535635 -0.12388385689028192 TSACGLFSVCYPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSACGLFSVCYPR 13 0 P30153;C9J9C1;P30154;P30154-2;P30154-4;P30154-3 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 0 121023000.0 28051000.0 52918000.0 40054000.0 False True 42555417.80279411 43474369.4497789 32137309.34370812 1.0 1.0215942339291157 0.7551872594139599 25.3428394797809 -6.887260047265224 1.0384306459187596 1.0152686056821951 0.7334650269923224 0.9790867439867683 0.017471950589043946 0.12139538825182856 0.2350468313790767 0.012863616193277144 0.03176934265714798 1.2964027772375155e-07 6.887260047265224 -0.2818035786898727 TSACGLFSVCYPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSACGLFSVCYPR 13 0 P30153;C9J9C1;P30154;P30154-2;P30154-4;P30154-3 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 0 59270000.0 17895000.0 18341000.0 23034000.0 False True 24511265.09419148 17530633.974423703 17593843.60012095 1.0 0.715207228474633 0.7177860274658049 24.546941611819598 -10.049120423615728 4.894312482347382 1.0000062900794235 0.7164966291933175 0.9999379465533611 0.001052790290422036 7.226085074914957e-08 1.4037888079568212e-08 0.0010193824156911498 0.000339786603611087 8.930578173049848e-11 10.049120423615728 -0.2835096608861061 TSACGLFSVCYPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSACGLFSVCYPR 13 0 P30153;C9J9C1;P30154;P30154-2;P30154-4;P30154-3 P30153;P30154 PPP2R1A;PPP2R1B Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform 0 122172000.0 28051000.0 51174000.0 42947000.0 False True 36312572.467875265 48326121.9144387 35131086.67343277 1.0 1.330837190264928 0.9674634509717612 25.11396580187335 -6.667132393929309 1.9480239263729502 1.2116974658922668 0.968965027818822 0.2662025764898929 0.14062728037472302 0.4677341966688962 3.4192804633022056 0.058180868074541384 0.15600071419264913 2.1521255629195464e-07 6.667132393929309 -0.2427324380734448 TSAEAPSHHLQQQQQQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSAEAPSHHLQQQQQQQR 18 0 C9J3F6;Q92609;Q92609-2 C9J3F6 TBC1D5 TBC1 domain family member 5 0 2574030.0 305130.0 1123400.0 1145500.0 False True 400028.38488312304 955793.0989789021 1026974.6484118935 1.0 2.389313196507687 2.5672544429864557 18.609742847629835 -10.524943364588756 0.4158329603505335 4.294699904916459e-14 2.5787220954800225 0.9993539724685253 0.017808363367464237 1.9910148267436274 0.1970287124332802 2.1497846889663497 0.04346185888941633 2.985771961643787e-11 10.524943364588756 2.5787220954799794 TSAEAPSHHLQQQQQQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSAEAPSHHLQQQQQQQR 18 0 C9J3F6;Q92609;Q92609-2 C9J3F6 TBC1D5 TBC1 domain family member 5 0 1448400.0 305130.0 637590.0 505680.0 False True 417944.8068282 609419.1655718229 386248.79880651017 1.0 1.458133120965731 0.9241622159102009 18.672952909152727 -6.679596633598477 1.903027334858129 1.2899755052284996 0.9261902078590094 0.3222857111190325 0.1941859745508353 0.43949270754501896 3.0768285542632094 0.08188285582634584 0.21609539809375966 2.091237540165428e-07 6.679596633598477 -0.36378529736949017 TSAK(ub)EEDAFHFVSYVPVNGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSAKEEDAFHFVSYVPVNGR 20 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 218353000.0 52960000.0 97837000.0 67556000.0 True False 69431072.86536959 83240100.96563913 60565953.16291048 1.0 1.198888300733102 0.8723176909616673 26.04907812868754 -6.7418794478466175 1.679986967377402 1.1180797083615541 0.8720528984364474 0.6132947686755048 0.08356140403699928 0.31441768006036036 1.74314683026119 0.039338889591167776 0.0963292565377143 1.8118429570746386e-07 6.7418794478466175 -0.24602680992510673 TSAK(ub)EEDAFHFVSYVPVNGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSAKEEDAFHFVSYVPVNGR 20 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 305808000.0 101155000.0 80299000.0 124354000.0 True False 97943889.89444758 112362809.453753 91781956.85996592 1.0 1.147216121136749 0.9370871113948785 26.545452158808217 -6.718371173448794 1.7650727414717993 1.0897194799513954 0.9374420341477121 0.504858323366712 0.06196179103895054 0.35849611490641003 2.181852180347356 0.02788236891884442 0.07013236057712068 1.9126205889455362e-07 6.718371173448794 -0.1522774458036833 TSAK(ub)EEDAFHFVSYVPVNGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSAKEEDAFHFVSYVPVNGR 20 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 967300000.0 264343000.0 330377000.0 372580000.0 True False 401027657.0619225 271418643.1027172 298939399.6923846 1.0 0.6768077919892882 0.7454333745520836 28.579126495355563 -10.852216053161825 7.370685419503643 1.023520557764289 0.711120583270686 0.9593933755834859 0.028016276763347902 0.010103259157924647 0.00020257245278159917 0.025309863684463245 0.009042214443932028 1.4053482164577239e-11 10.852216053161825 -0.312399974493603 TSAK(ub)EEDAFHFVSYVPVNGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSAKEEDAFHFVSYVPVNGR 20 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 207359000.0 52960000.0 74011000.0 80388000.0 True False 72540743.19018614 70740949.29835194 61402010.04282898 1.0 0.9751891997147654 0.8464485934731353 26.112288190210432 -6.938985100327956 0.6689743694588316 1.0014736075377002 0.8127479218587362 0.9980274297776137 0.0029891834275584395 0.08823354069125772 0.056748921420920445 0.002887770408871914 0.01113097719762362 1.1508398710084055e-07 6.938985100327956 -0.18872568567896397 TSAK(ub)EEDAFHFVSYVPVNGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSAKEEDAFHFVSYVPVNGR 20 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 316679000.0 101155000.0 110253000.0 105271000.0 True False 84114864.42631648 109659045.20549284 127282679.38189061 1.0 1.3036821250725872 1.5132007909658889 26.325857434242494 -7.112370438180882 0.06524855523627406 3.918526644971618e-10 2.793357705853445 0.9999999452988784 4.8936327025671144e-05 0.07865827730478145 0.0022081475919208476 0.03886098914080122 0.05506091177210617 7.720217962677211e-08 7.112370438180882 2.793357705461592 TSAK(ub)EEDAFHFVSYVPVNGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSAKEEDAFHFVSYVPVNGR 20 1 Q9Y5K5-3;Q9Y5K5;Q9Y5K5-2;Q9Y5K5-4;Q5LJB0;H0Y6Y4;H0Y4E0;Q5LJA5;Q5LJA9 Q9Y5K5-3;Q5LJA5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5;Ubiquitin carboxyl-terminal hydrolase 1 763192000.0 264343000.0 266069000.0 232780000.0 True False 342197224.4795387 251262026.25655204 190416428.52449945 1.0 0.7342608539233666 0.5564522880456185 28.350252817448013 -8.230075618407545 0.1048271076474819 1.5122921772085753 7.458787298901763e-12 0.9999826351018799 0.0007594767622035081 0.08466415529633307 0.021027497695250325 0.14180351750397713 0.1453041634613559 5.887411361086663e-09 8.230075618407545 -1.5122921772011166 TSALSDETK(ub)NNWEVSALSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSALSDETKNNWEVSALSR 19 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 14123800.0 3614400.0 4988400.0 5521000.0 True False 4738513.401899391 4244150.1646309085 4949739.8811716 1.0 0.8956712379307988 1.044576528830232 22.17600308749868 -6.718370492810125 1.7651465066034215 0.9364171712507021 1.0443237683886586 0.5048109114987555 0.04391099103445647 0.3585035107549911 2.1820944519735983 0.019759103836886213 0.04969867065829247 1.9126235864612918e-07 6.718370492810125 0.10790659713795647 TSALSDETK(ub)NNWEVSALSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSALSDETKNNWEVSALSR 19 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 15028100.0 2523300.0 7219500.0 5285300.0 True False 2443199.2226845906 10102283.999195142 3900921.3743987144 1.0 4.134858879045786 1.596644816427363 21.220340077571386 -6.593729526042599 2.2146318203608186 3.116742847901248 1.6043510859090002 0.0029608117739524653 1.3571469185351006 0.6586593082023563 6.095715680253478 0.5104888337624635 1.511424426705802 2.5484168852389e-07 6.593729526042599 -1.5123917619922476 TSALSDETK(ub)NNWEVSALSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSALSDETKNNWEVSALSR 19 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 66226000.0 8457000.0 17149000.0 40620000.0 True False 12829887.289516592 14088626.964251438 32591439.195621554 1.0 1.0981099557876375 2.5402747865331827 23.613005160627463 -6.9206749652346735 0.8197150342019086 0.9689473587538364 2.776478600043669 0.9943661892775225 0.052849433803190606 0.09777611358349886 0.10357135085471857 0.04569870406213763 0.13778312095470494 1.2003973686874312e-07 6.9206749652346735 1.8075312412898326 up TSALSDETK(ub)NNWEVSALSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSALSDETKNNWEVSALSR 19 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 15118700.0 3614400.0 7025700.0 4478600.0 True False 4950741.355487324 6715281.343116974 3420846.9196623093 1.0 1.3564193442814099 0.6909766990494658 22.239213149021573 -6.76121747813463 1.6078156775134795 1.2067205728568322 0.6883952799055545 0.6958934199810971 0.14993906447806152 0.28090469858850037 1.4314451820039722 0.07356878571895539 0.17659055293892117 1.7329359921014047e-07 6.76121747813463 -0.5183252929512777 TSALSDETK(ub)NNWEVSALSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSALSDETKNNWEVSALSR 19 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 15952100.0 2523300.0 7649500.0 5779300.0 True False 2098235.7511435375 7608290.625193124 6987724.909535963 1.0 3.626041840649512 3.33028588695415 21.000745353005662 -9.802860676633724 7.440882582650364 0.999999996935559 3.478163863801842 0.9894305224639084 0.12074186249067995 6.397544100544961e-09 9.364814086291894e-10 0.11690780478306857 0.03896926855136663 1.5744878853195782e-10 9.802860676633724 2.478163866866283 TSASIILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSASIILR 8 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 229740000.0 65044000.0 75965000.0 88731000.0 False True 85273313.886992 64631318.10925075 79549967.28785318 1.0 0.7579313522974264 0.9328823246306148 26.34559098785937 -9.808272977144105 5.291325086512888 1.00000007644956 0.8454068386401017 0.5100647191887817 0.07142343538707381 6.440429705995926e-08 1.441166600174763e-08 0.0691554779447148 0.023051814646126958 1.5549879318798533e-10 9.808272977144105 -0.15459323780945833 TSASIILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSASIILR 8 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 126654000.0 49126000.0 20947000.0 56581000.0 False True 47566522.02021281 29311246.337161954 41760738.70638439 1.0 0.6162158823532757 0.8779439179647963 25.50344320606376 -10.082460017878748 5.273496270938044 1.0000036672428494 0.7470799001587283 0.5545859400868534 0.10685002310594498 4.607001768349567e-06 8.016074989327817e-07 0.10345858982017674 0.03448569666911164 8.270656465762173e-11 10.082460017878748 -0.2529237670841211 TSASIILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSASIILR 8 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 215441000.0 54388000.0 84505000.0 76548000.0 False True 82510572.29540353 69424422.50942145 61418254.24781979 1.0 0.8414003269892352 0.7443682977731723 26.298075651702476 TSASIILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSASIILR 8 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 182583000.0 65044000.0 57168000.0 60371000.0 False True 89092524.54800725 54642128.73070467 46112613.17977351 1.0 0.6133188952487357 0.5175811709648643 26.408801049382262 -13.999999999999998 0.1960552125776017 3.1180565812314867 0.4529309793684662 0.9994872019168934 0.004722487941062906 12.455666152567918 0.14041150615353176 10.100542169805856 0.06280385878874896 1.0000000000000041e-14 13.999999999999998 -2.6651256018630205 TSASIILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSASIILR 8 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 104484000.0 49126000.0 33987000.0 21371000.0 False True 40850445.65080539 33803905.28510867 25839577.291660413 1.0 0.8275039536672033 0.632540891047806 25.283848481498037 -6.969534158199145 0.2690797755565434 1.0490102660599268 0.40518060127224687 0.9999785164903623 0.0006957311890516916 0.07645413310324273 0.009569733465653023 0.003843361950348252 0.01815570235205055 1.0726692767618412e-07 6.969534158199145 -0.6438296647876799 TSASIILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSASIILR 8 0 P17987;E7ERF2;E7EQR6;F5H282;F5GZ03 P17987 TCP1 T-complex protein 1 subunit alpha 0 225938000.0 54388000.0 105700000.0 65850000.0 False True 70406338.14775938 99817702.08223249 53865975.67805773 1.0 1.4177374467728812 0.7650728200778039 26.069201973794925 -6.733808260651229 1.7091134101403227 1.250316577969864 0.7651656904150222 0.5769276701303127 0.17556079687243972 0.3291457375056434 1.885197929124159 0.08134183365536918 0.20099769337233347 1.8458301662542788e-07 6.733808260651229 -0.4851508875548417 TSATVGPK(ub)APSGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSATVGPKAPSGGK 14 1 P16104 P16104 H2AFX Histone H2AX 1 10276740.0 638750.0 6466100.0 3171890.0 True False 837407.4356637996 5501383.08466039 2843693.2497173278 1.0 6.569541719317946 3.395829949208866 19.675570202817944 -9.413118414479289 9.548392636264587 0.9999907646620433 4.982685834263424 0.6773874409853744 1.295662404583096 0.0 0.0 1.254519728809366 0.41817324293645525 3.8626164482077054e-10 9.413118414479289 3.9826950696013803 TSATVGPK(ub)APSGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSATVGPKAPSGGK 14 1 P16104 P16104 H2AFX Histone H2AX 1 18379400.0 6077700.0 8493400.0 3808300.0 True False 5884766.740264776 11884858.91249588 2810791.9834489278 1.0 2.0195972817711274 0.477638640154913 22.48855380033425 -6.728378902252165 1.728960377713882 1.6146874417493342 0.47879288256261254 0.5518146971794853 0.4286721144495816 0.3392847849101706 1.9861725514178425 0.19653278597783852 0.4886140014735895 1.8690507667355123e-07 6.728378902252165 -1.1358945591867218 TSATVGPK(ub)APSGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSATVGPKAPSGGK 14 1 P16104 P16104 H2AFX Histone H2AX 1 10700210.0 638750.0 7071100.0 2990360.0 True False 874913.1365697018 6758675.420999254 2284098.5563974003 1.0 7.72496735790046 2.610657516645291 19.738780264340836 -6.5766746436667685 2.279310526646583 5.588756390937759 2.622502160701869 0.0 2.9240101449454676 0.7097028824946463 6.929915143779861 1.0792382304744057 3.2725789973565984 2.650485034082974e-07 6.5766746436667685 -2.9662542302358896 TSATWLALSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSATWLALSR 10 0 P05023-4;P05023;P05023-3;P05023-2 P05023-4 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 0 18666700.0 5519400.0 5675700.0 7471600.0 False True 7235986.84994563 4828907.683705325 6698510.504648023 1.0 0.6673461110203108 0.925721763120445 22.78675835545698 -10.422352077098276 5.847569540578282 1.000085242383051 0.7965339370703778 0.45260557377308563 0.10548141826736616 0.00011727087467656914 1.1584458986845885e-05 0.10217459751542787 0.034043981356987246 3.7813591037781185e-11 10.422352077098276 -0.2035513053126733 TSATWLALSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSATWLALSR 10 0 P05023-4;P05023;P05023-3;P05023-2 P05023-4 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 0 13026900.0 5519400.0 3812800.0 3694700.0 False True 7560071.336176606 3644337.888756479 2822087.9547350383 1.0 0.4820507276588145 0.37328853515319704 22.84996841697987 -13.999999999999964 0.21936448043827028 4.116848732076203 0.31475594448768957 0.9994972634768292 0.00613075109154232 12.982388319554943 0.14837942932870746 17.52267524608974 0.060444842407214046 1.0000000000000819e-14 13.999999999999964 -3.8020927875885135 TSATWLALSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSATWLALSR 10 0 P05023-4;P05023;P05023-3;P05023-2 P05023-4 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 0 5664000.0 2086400.0 1851100.0 1726500.0 False True 1734934.043191802 1841127.7568854173 2087503.167565941 1.0 1.0612090782991659 1.2032175953648987 20.726449386381983 -6.957041809136328 0.47529365711001237 0.9964357663621599 1.2738647434439296 0.9996442584321372 0.001605467611326668 0.080775276112065 0.025167989964660967 0.0019835632126037187 0.01171690771309516 1.1039723363695562e-07 6.957041809136328 0.2774289770817697 TSCTK(ub)EDCKDDILINCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSCTKEDCKDDILINCR 17 2 Q58WW2;Q58WW2-2;Q58WW2-4;Q58WW2-3;F2Z305 Q58WW2 DCAF6 DDB1- and CUL4-associated factor 6 1 6799600.0 2887100.0 1837800.0 2074700.0 True False 3954538.890943846 1756599.9192081064 1584698.5897877477 1.0 0.4441984179826466 0.40072904414135657 21.915078052004183 -13.999999999999998 0.3613250612239536 8.33255174771646 0.3955938128710594 0.9997756799711972 0.004086271946889089 21.84002665707507 0.1943689985253634 123.56410465324015 0.012489395585001187 1.0000000000000041e-14 13.999999999999998 -7.936957934845401 TSDDVAK(ub)EFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSDDVAKEFVR 11 1 Q8NB66;A0A3B3ISZ1;A0A0C4DGH4 Q8NB66 UNC13C Protein unc-13 homolog C 1 47461000.0 9276000.0 11092000.0 27093000.0 True False 12007964.85729602 10474720.449348383 22162351.997655567 1.0 0.8723143824812212 1.845637646431798 23.517488324074336 -6.873887969306097 1.1133841012916736 0.9257829180737751 1.9070001851815128 0.968408904593564 0.07676372072100698 0.13317861422028807 0.3062139706960325 0.05337338456364702 0.1272832180077297 1.3369403494755558e-07 6.873887969306097 0.9812172671077377 TSDFNTFLAQEGCTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSDFNTFLAQEGCTK 15 0 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 19107100.0 3002000.0 7360200.0 8744900.0 False True 3935651.071409351 6262086.849834889 7840061.635004083 1.0 1.59111840359172 1.9920621754195724 21.908170888613647 -8.05863407099934 0.11318692408680228 5.6595254032662264e-15 3.153743503265762 0.9999816016134709 0.001747811037926468 0.10112514382264993 0.020061961306647363 0.24742108974952426 0.277743310534183 8.737072288956688e-09 8.05863407099934 3.153743503265756 TSDFNTFLAQEGCTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSDFNTFLAQEGCTK 15 0 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 6571500.0 2464300.0 0.0 4107200.0 False True 2386072.145389619 0.0 3031401.1066411342 1.0 0.0 1.2704566006096771 21.186206234411912 -6.696800066634724 1.842033507770461 0.3771165510045062 1.266491138995238 0.4025346165011259 0.42236279947514976 0.4022075798189532 2.650865507320975 0.1830716673808699 0.47272402166407956 2.0100179387123515e-07 6.696800066634724 0.8893745879907318 TSDFNTFLAQEGCTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSDFNTFLAQEGCTK 15 0 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 13409600.0 3002000.0 5499200.0 4908400.0 False True 4111920.5259995945 5256227.160577442 3749137.011671166 1.0 1.2782900660025938 0.9117727319789973 21.97138095013654 -6.703716507817361 1.8179193997083432 1.1721761724834334 0.9127944191593602 0.4351194618064683 0.11739185951300428 0.3878273895282919 2.4943777530141356 0.05147054536876341 0.1317498929551355 1.9782605577363498e-07 6.703716507817361 -0.2593817533240732 TSDFNTFLAQEGCTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSDFNTFLAQEGCTK 15 0 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 16030900.0 6900400.0 4680100.0 4450400.0 False True 8932703.827219227 4419648.320861464 3640472.864960188 1.0 0.4947716174574336 0.4075443376805068 23.090665498052257 -13.999999999999998 0.2471046185969371 4.4630001861871085 0.371492827064206 0.9995373316360616 0.00561760147157967 13.88502114878454 0.15730396453526907 23.8263433400568 0.0409132546992257 1.0000000000000041e-14 13.999999999999998 -4.091507359122902 TSDFNTFLAQEGCTK(ub)GK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSDFNTFLAQEGCTKGK 17 1 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 1 18304900.0 3947000.0 3297900.0 11060000.0 True False 5109469.307001658 3114368.965912907 9047193.485183282 1.0 0.6095288529564498 1.7706718529037142 22.284742023321435 -6.81601492317024 1.3890492800549534 0.7886480263168768 1.7939114645692302 0.874949843961881 0.17059928531839785 0.1987231006788354 0.7544656836921007 0.09653824268099946 0.2227736233101639 1.527513569114597e-07 6.81601492317024 1.0052634382523533 TSDIFGSPVTATSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSDIFGSPVTATSR 14 0 A6NGP5;Q9H910;Q9H910-3;H3BU16;H3BMV3;Q9H910-2;H3BMT0;H3BTV5 A6NGP5 HN1L Hematological and neurological expressed 1-like protein 0 18207800.0 8335900.0 3210500.0 6661400.0 False True 8071281.417340968 4492469.392536324 4916579.502283615 1.0 0.5565992759073366 0.609144849257821 22.944366306976377 -10.369894977718245 6.78173340956127 1.0000222363828781 0.5828720625836962 0.988238658823308 0.021451640491778765 7.212582578073392e-06 6.701268398138146e-07 0.020771566200773996 0.006923487197790648 4.266826879036435e-11 10.369894977718245 -0.41715017379918196 TSDIFGSPVTATSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSDIFGSPVTATSR 14 0 A6NGP5;Q9H910;Q9H910-3;H3BU16;H3BMV3;Q9H910-2;H3BMT0;H3BTV5 A6NGP5 HN1L Hematological and neurological expressed 1-like protein 0 17704400.0 2369000.0 7750500.0 7584900.0 False True 3244883.3198178024 7408057.282523894 5793502.835918964 1.0 2.282996506308846 1.7854271679156293 21.62973517175608 -10.390205425794832 5.420788716285787 0.9994882687512849 2.0342118371122506 0.8520791441429102 0.20313183178631275 0.0012568432885782183 0.00014138421553843363 0.19677074149048884 0.06556051679940961 4.071876282732029e-11 10.390205425794832 1.0347235683609657 TSDIK(ub)ELNIVLPEFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSDIKELNIVLPEFEK 16 1 Q09GN1;Q71F23-3;Q71F23;Q71F23-2 Q09GN1 MLF1IP;CENPU Centromere protein U 1 7053400.0 2647100.0 2429200.0 1977100.0 True False 2563069.2594492855 3399192.2281106478 1459238.1982713738 1.0 1.3262194205555788 0.5693323318874782 21.289441033093727 -6.789584892236369 1.497988897822197 1.1824277458977543 0.5613764242551265 0.7999463570988058 0.13864453019165984 0.2359895813183851 1.0461603014557574 0.07285174316023477 0.1706156548565261 1.6233609984983366e-07 6.789584892236369 -0.6210513216426279 TSDLIVLGLPWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSDLIVLGLPWK 12 0 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 0 36658000.0 10127000.0 14439000.0 12092000.0 False True 13276595.07000749 12284757.482781181 10840835.834654404 1.0 0.9252942804991529 0.8165373559629312 23.66238186319572 -6.965749694795155 0.3449476342584532 1.0111402361677955 0.7270498417647916 0.9999277657247525 0.0006401846816712315 0.07770751253934202 0.013968299934176979 0.0015131552930880818 0.00938013864008617 1.0820574143593344e-07 6.965749694795155 -0.2840903944030039 TSDLIVLGLPWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSDLIVLGLPWK 12 0 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 0 54415000.0 22301000.0 13820000.0 18294000.0 False True 21593066.961950243 19338398.07034794 13502252.591763966 1.0 0.8955836660176473 0.6253049932905164 24.36406483469339 -6.954712175612303 0.5044686066334616 1.005209412702667 0.5039329503319214 0.9995210625821741 0.003455256164658137 0.08164696461131468 0.028545174211146294 0.004018865655543353 0.022299638498773762 1.1099101535819531e-07 6.954712175612303 -0.5012764623707455 TSDLIVLGLPWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSDLIVLGLPWK 12 0 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 0 51568000.0 13463000.0 24240000.0 13865000.0 False True 20424355.27713868 19914182.612015564 11124576.672754625 1.0 0.9750213576780972 0.5446721094401715 24.283787202648337 -6.918823477851447 0.8334061669164369 1.0099040667017833 0.4771183123431341 0.9938477918107277 0.016393519745863082 0.09886909640711916 0.10923793685634067 0.014037380632688131 0.04158713293676917 1.2055258355417533e-07 6.918823477851447 -0.5327857543586492 TSDLIVLGLPWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSDLIVLGLPWK 12 0 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 0 61626000.0 10127000.0 19149000.0 32350000.0 False True 13871225.571884703 18302933.862725 24709596.26916352 1.0 1.3194893102901328 1.7813563870842735 23.72559192471861 -6.965863355993071 0.34291133014036046 0.9515636095833949 2.1646992190357635 0.9999298524345942 0.002686389606034214 0.0776691880872339 0.0138336280304249 0.006463519600553326 0.0398926335753904 1.0817742612118987e-07 6.965863355993071 1.2131356094523684 TSDLIVLGLPWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSDLIVLGLPWK 12 0 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 0 40642300.0 22301000.0 8834800.0 9506500.0 False True 18544269.60181192 8787205.178829506 11494265.19691027 1.0 0.47385016328553203 0.6198284129662993 24.144470110127667 -10.530584401117105 9.514348746626771 1.0000154906105507 0.5468392881259527 0.9277922501958393 0.0595953708770802 1.9582868822059944e-05 9.662448277366322e-07 0.05770493558407302 0.01923432324316551 2.947240651975983e-11 10.530584401117105 -0.453176202484598 TSDLIVLGLPWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSDLIVLGLPWK 12 0 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 0 36705500.0 13463000.0 14913000.0 8329500.0 False True 17428118.895404965 14083078.440419426 6813616.46788736 1.0 0.8080664657464851 0.39095535833668277 24.054913524740787 -6.958388437784966 0.45758075097525647 1.0124562432850697 0.16981907884797495 0.9997056787184804 0.004361736836808458 0.0802819102720702 0.023296965325723135 0.005641923323741684 0.0344670680424655 1.1005545210759015e-07 6.958388437784966 -0.8426371644370947 down TSDLIVLGLPWK(ub)TTEQDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSDLIVLGLPWKTTEQDLK 19 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 24054900.0 4585300.0 14269000.0 5200600.0 True False 6011372.70410837 12140120.82012638 4662491.799677774 1.0 2.019525558917587 0.7756118326337135 22.519263039009378 -6.688873085879409 1.8701471877818758 1.6398592571720212 0.7799431882073216 0.3651784455079583 0.431288807163789 0.4191523512711104 2.841291816253614 0.18453926839388762 0.4812852139447334 2.047042757781668e-07 6.688873085879409 -0.8599160689646996 TSDLIVLGLPWK(ub)TTEQDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSDLIVLGLPWKTTEQDLK 19 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 94373000.0 41468000.0 28985000.0 23920000.0 True False 40151621.03843556 40558861.65477823 17654634.41538174 1.0 1.010142569734677 0.4396991692684501 25.258954898950442 -6.9028532610529965 0.9430522504468039 1.0218961404104934 0.37622707731310556 0.9879331898368504 0.029280383944605953 0.10933546171555264 0.16581103851342224 0.02315557468633702 0.0611569001008391 1.250681537752657e-07 6.9028532610529965 -0.6456690630973878 down TSDLIVLGLPWK(ub)TTEQDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSDLIVLGLPWKTTEQDLK 19 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 248637000.0 27463000.0 51766000.0 169408000.0 True False 41663378.81423602 42527952.85039599 135924434.5458358 1.0 1.0207514143299523 3.262443863515735 25.31227650793184 -6.908924202195853 0.9030046062098592 0.9282086198668599 3.5456003020224993 0.9905097883226719 0.10342536188190163 0.10513447803600506 0.14264846285479937 0.08422780754788024 0.23081711443324404 1.2333200668996546e-07 6.908924202195853 2.6173916821556396 up TSDLIVLGLPWK(ub)TTEQDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSDLIVLGLPWKTTEQDLK 19 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 42120300.0 4585300.0 13173000.0 24362000.0 True False 6280609.323073274 12590973.302714305 18608197.351139456 1.0 2.0047375429734893 2.962801281521831 22.58247310053227 -6.971703082730139 0.21362761938017127 0.5210402262511832 4.47335404806741 0.9999927943621738 0.0021511776796537367 0.0757538483323567 0.007017701595749483 0.027880297483640324 0.09846210172337419 1.0673255780928044e-07 6.971703082730139 3.952313821816227 TSDLIVLGLPWK(ub)TTEQDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSDLIVLGLPWKTTEQDLK 19 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 78398000.0 41468000.0 23743000.0 13187000.0 True False 34482479.343883045 23615091.7463835 15944340.730201006 1.0 0.6848432072090157 0.46238962608207645 25.03936017438472 -7.879972989934394 0.14799492235405984 1.3451248943466465 2.735910106046118e-16 0.9999623914938048 0.0013526104193840299 0.12129683009895101 0.022061098720527316 0.0784366639937764 0.10323984286153153 1.3183387274135717e-08 7.879972989934394 -1.3451248943466463 down TSDLIVLGLPWK(ub)TTEQDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSDLIVLGLPWKTTEQDLK 19 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 254727000.0 27463000.0 38044000.0 189220000.0 True False 35551394.876662455 35926817.95663628 154783901.56115553 1.0 1.0105600098470473 4.353806709923573 25.08340283002429 -6.907591858064201 0.911977388926338 0.8884391649028892 4.764329166822198 0.9899806646174784 0.15800418368191466 0.10603201483592042 0.14756443955082635 0.1278392915412632 0.34727510738460143 1.2371094999822183e-07 6.907591858064201 3.8758900019193088 up TSDTIAPWFHGILTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSDTIAPWFHGILTLK 16 0 Q9H788;Q9H788-2 Q9H788 SH2D4A SH2 domain-containing protein 4A 0 9759100.0 4307000.0 2412200.0 3039900.0 False True 4170276.64253261 3375404.03945682 2243658.9949548068 1.0 0.8093957137114377 0.5380120282841073 21.99171165984585 -6.966109441290834 0.338477852244558 1.0299593472781141 0.30845042020107455 0.9999342149131967 0.0015375082838083236 0.07758654193481096 0.013543903899417932 0.003849049835020722 0.023515798128260223 1.0811614665638542e-07 6.966109441290834 -0.7215089270770396 TSDTIAPWFHGILTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSDTIAPWFHGILTLK 16 0 Q9H788;Q9H788-2 Q9H788 SH2D4A SH2 domain-containing protein 4A 0 18357300.0 4693800.0 6969300.0 6694200.0 False True 7120837.762744817 5725573.963610569 5371088.435827913 1.0 0.8040590383291606 0.7542776025496133 22.76361555279912 -13.999999999999998 0.19239581148910587 2.059201597692264 0.7194122008815416 0.9994882659614499 0.0023993761272612575 12.390680258322615 0.139099019434238 4.924227846662058 0.03359418186078121 1.0000000000000041e-14 13.999999999999998 -1.3397893968107224 TSDTIAPWFHGILTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSDTIAPWFHGILTLK 16 0 Q9H788;Q9H788-2 Q9H788 SH2D4A SH2 domain-containing protein 4A 0 4518050.0 473850.0 1368600.0 2675600.0 False True 649045.1503147602 1308130.726645017 2043678.3857117167 1.0 2.015469533992554 3.148746099898623 19.307959316096518 -6.969706008635468 0.26511543785104474 0.7010602439289509 4.497004549569999 0.9999799975336751 0.003925258336618703 0.0763982179660793 0.00937101744111445 0.02289845990912354 0.10612695049392269 1.0722449052252458e-07 6.969706008635468 3.795944305641048 TSDTIAPWFHGILTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSDTIAPWFHGILTLK 16 0 Q9H788;Q9H788-2 Q9H788 SH2D4A SH2 domain-containing protein 4A 0 7491500.0 4307000.0 1252200.0 1932300.0 False True 3581461.332451638 1245454.150057762 2336334.9960542484 1.0 0.34775027131319164 0.6523412593861355 21.772116935280128 -10.507631490253235 6.311351457659998 1.0003903188625862 0.5000457653498014 0.7822412655590532 0.12434875017147827 0.0006834551702222865 5.331847225625514e-05 0.12049026074720232 0.040133386544653475 3.1071950026561187e-11 10.507631490253235 -0.5003445535127848 TSDTIAPWFHGILTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSDTIAPWFHGILTLK 16 0 Q9H788;Q9H788-2 Q9H788 SH2D4A SH2 domain-containing protein 4A 0 11324900.0 4693800.0 6631100.0 0.0 False True 6076216.628630452 6262073.455794619 0.0 1.0 1.0305875906873416 0.0 22.53474187489157 -7.0015492744699825 1.1194843710361992 1.0320771384281138 4.345823379029407e-20 0.9833847912442639 0.061714347357344566 0.09167996466776095 0.2247647005132782 0.046423826382189545 0.08507353116179137 9.964390190850881e-08 7.0015492744699825 -1.0320771384281138 down TSEATK(ub)MHAPPINMESVHMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSEATKMHAPPINMESVHMK 20 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 11704300.0 2632400.0 4358900.0 4713000.0 True False 2548835.9029029077 6099431.501363203 3478523.913030696 1.0 2.3930263593731036 1.3647500449397125 21.281407063245723 -10.091045243547288 4.8081744358361185 0.9999625441588795 1.878888201712548 0.49343014802906016 0.41979204752359217 0.00016856013113161782 3.186502019274852e-05 0.4064791529183564 0.1354873007395954 8.108765786688714e-11 10.091045243547288 0.8789256575536684 TSEATK(ub)MHAPPINMESVHMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TSEATKMHAPPINMESVHMK 20 1 P48444;B0YIW6;P48444-2 P48444 ARCN1 Coatomer subunit delta 1 18675800.0 4587600.0 7700700.0 6387500.0 True False 3814792.6651393333 7659214.800630732 7723096.71753689 1.0 2.0077669936358085 2.024512836074358 21.86317321770671 -10.986679987124342 0.6963881895163679 7.03342549132624e-14 2.0216159226791715 0.9999697644273563 0.002634204797730509 2.9800939052844764 0.35518854103604003 4.791665033996138 0.0026191882109555496 1.0311456473374294e-11 10.986679987124342 2.0216159226791013 TSEESWIEQQMLEDK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 2 TSEESWIEQQMLEDKK 16 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 79746200.0 49865800.0 15459100.0 14421300.0 True False 65374546.70109416 13152662.539099827 12929122.214877717 1.0 0.20118934972102367 0.19776997114782788 25.962225702139364 TSEESWIEQQMLEDK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 2 TSEESWIEQQMLEDKK 16 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 119448100.0 49760200.0 40969900.0 28718000.0 True False 48180589.68835637 57329394.725206055 21195894.278467126 1.0 1.1898857007775612 0.4399260037199059 25.52194871522381 -6.839600472296371 1.2843314151063976 1.101018254935822 0.415465916694278 0.9237522587771531 0.0879087839528393 0.16926596785781745 0.5425453669735689 0.05367634670442658 0.12364130946724113 1.4467701098806356e-07 6.839600472296371 -0.685552338241544 down TSEESWIEQQMLEDK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 2 TSEESWIEQQMLEDKK 16 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 647506100.0 309724100.0 292432000.0 45350000.0 True False 469874103.56473523 240245224.8183555 36386552.62238891 1.0 0.5112970112541148 0.07743894023173353 28.807699016967202 -7.95120545308197 0.46278025282901625 1.0360990607035476 4.6344571468212776e-20 0.9956869888999742 0.02474944297342653 0.10303878630802547 0.10562051520358798 0.04073262486402085 0.07906157813397381 1.1189084326454768e-08 7.95120545308197 -1.0360990607035476 down TSEESWIEQQMLEDK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TSEESWIEQQMLEDKK 16 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 150992700.0 49865800.0 81500100.0 19626800.0 True False 68302533.83257523 77899156.09720995 14991354.06663428 1.0 1.140501702149999 0.219484596331103 26.025435763662255 -6.8679949735957155 1.144587306544776 1.0785830870868887 0.1675473557973603 0.962644091640789 0.07830340030660264 0.13879516610619386 0.34108740688579114 0.05315318762111986 0.12542827398019923 1.3552050970294537e-07 6.8679949735957155 -0.9110357312895283 down TSEESWIEQQMLEDK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSEESWIEQQMLEDKK 16 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 107124300.0 19616000.0 17568000.0 69940300.0 True False 16311573.13614378 17473357.697025027 84564493.36259027 1.0 1.0712245564044907 5.184324813846996 23.95939259072905 -6.910655564761286 0.8912372421810936 0.8752747041386274 5.723434234928263 0.9911670879005041 0.18382604194676289 0.10398670010758794 0.13641973447296216 0.15099022093407835 0.41873059156511905 1.2284130888413793e-07 6.910655564761286 4.848159530789635 up TSEESWIEQQMLEDK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TSEESWIEQQMLEDKK 16 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 533265600.0 309724100.0 94901000.0 128640500.0 True False 400943953.0247567 89619675.92531654 105229248.9629947 1.0 0.2235217048398355 0.2624537623504131 28.57882533905965 -10.030651609246487 5.453945453319272 1.0000036030635908 0.2429877335947145 0.9980202536325244 0.015893945926530848 87900763.94685745 61.36485534010311 4317.654365542369 0.00544092044426581 9.318551092806724e-11 10.030651609246487 -0.7570158694688763 TSEESWIEQQMLEDK(ub)KR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSEESWIEQQMLEDKKR 17 2 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 128215600.0 61882000.0 46635500.0 19698100.0 True False 81127901.26614048 39677665.183755204 17659929.569517516 1.0 0.48907545449243695 0.2176800988797187 26.273694831374833 -9.028881731409964 0.22845510018552442 1.3537986354278295 1.5641614725186892e-26 0.9993593288228013 0.008209332931845833 0.4880491177079711 0.07685514120288275 0.2564827500561346 0.1236319317964683 9.356604417755646e-10 9.028881731409964 -1.3537986354278295 TSEESWIEQQMLEDK(ub)KR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSEESWIEQQMLEDKKR 17 2 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 183044500.0 76374000.0 60699300.0 45971200.0 True False 73949549.17501402 84936847.03266777 33929963.61356179 1.0 1.1485782939886553 0.4588258345329575 26.14003801633704 -6.850326159159658 1.233413657934358 1.0793139166561636 0.4310630156970834 0.9407899884515564 0.07212455249866209 0.15710078747126519 0.4597343119063409 0.04575150646467066 0.10590057114179416 1.411477114150971e-07 6.850326159159658 -0.6482509009590802 down TSEESWIEQQMLEDK(ub)KR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSEESWIEQQMLEDKKR 17 2 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 447346000.0 204055000.0 170330000.0 72961000.0 True False 309566353.4187427 139933280.7056357 58540226.37005774 1.0 0.45203000636297 0.1891039698712729 28.20567343344358 -9.338591645079555 0.23293882242190686 1.4094499466827377 3.3139616251623724e-17 0.9992530655038006 0.009231990033483925 0.753526732202656 0.08819115203375 0.35227946022467665 0.12146372041640748 4.5857286726857203e-10 9.338591645079555 -1.4094499466827377 TSEESWIEQQMLEDK(ub)KR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSEESWIEQQMLEDKKR 17 2 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 216381000.0 61882000.0 111960000.0 42539000.0 True False 84761447.69817029 107013236.99779056 32492164.318205476 1.0 1.2625225253213863 0.3833365899306941 26.336904892897724 -6.8266615514513 1.342660272394455 1.1406291153780288 0.3612334157796339 0.8990620681767528 0.11707655468421786 0.18495764593623956 0.6532490402880226 0.06848523193503837 0.1576507210535493 1.4905221989791716e-07 6.8266615514513 -0.7793956995983948 down TSEESWIEQQMLEDK(ub)KR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TSEESWIEQQMLEDKKR 17 2 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 393827100.0 78420300.0 223775000.0 91631800.0 True False 65209954.0583368 222569479.65914044 110791585.7224262 1.0 3.413121246183211 1.698998064364715 25.958588867540463 -6.557261217850033 2.357037272218618 2.6650167170526604 1.7014254153403818 0.0 1.0543134037749287 0.770297160319051 8.016543893838913 0.38118858756808316 1.1875905211609437 2.771652519816962e-07 6.557261217850033 -0.9635913017122786 TSEESWIEQQMLEDK(ub)KR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSEESWIEQQMLEDKKR 17 2 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 461790000.0 204055000.0 129746000.0 127989000.0 True False 264153220.0253926 122525521.04409985 104696315.27803998 1.0 0.46384261767591434 0.3963469204273781 27.976799755536028 -13.999999999999998 0.29222388817346656 5.678446926554983 0.3783627864577739 0.999632440550175 0.005177645713844555 16.09936226989834 0.17147796911039553 45.33829333756785 0.0252381704984258 1.0000000000000041e-14 13.999999999999998 -5.300084140097209 TSEESWIEQQMLEDKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 2 TSEESWIEQQMLEDKK 16 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 591871800.0 224416200.0 279528600.0 87927000.0 True False 294211811.449572 237824022.47394875 78829157.49534053 1.0 0.8083428782216374 0.2679333542285465 28.132279925398194 -6.952835722752301 0.5267963796851074 1.008723904555165 0.04315407276995104 0.9994054241258777 0.007558125616455172 0.08236671204575592 0.031401959296358015 0.008472632015050647 0.04467115211646965 1.1147161089793363e-07 6.952835722752301 -0.9655698317852139 down TSEESWIEQQMLEDKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 2 TSEESWIEQQMLEDKK 16 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 960635700.0 369830100.0 378188600.0 212617000.0 True False 358090045.9102617 529201280.2074952 156926229.32672325 1.0 1.4778441519151149 0.43823119664725163 28.415747174670216 -6.781722758051988 1.5291141765902059 1.2699599721211323 0.4295396418197562 0.7734587876201382 0.20222780095100817 0.24790377476340783 1.1450059191002893 0.10415176840294178 0.24540748462486825 1.6530167030054802e-07 6.781722758051988 -0.8404203303013762 down TSEESWIEQQMLEDKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSEESWIEQQMLEDKK 16 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 510690000.0 182120000.0 220180000.0 108390000.0 True False 249454685.60794345 210451719.56210735 82790514.36212158 1.0 0.8436470898480726 0.33188598626782123 27.89420252742241 -6.9494776476985844 0.5645544243301359 1.0065403822136447 0.14434306328468005 0.9991596127477896 0.008271570617085494 0.08369628540195623 0.03683647111241846 0.008818657802504848 0.04258453922255902 1.1233687858165508e-07 6.9494776476985844 -0.8621973189289647 down TSEESWIEQQMLEDKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSEESWIEQQMLEDKK 16 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 114026600.0 57450100.0 32688000.0 23888500.0 True False 47772303.620961115 32511903.255940024 28883474.902055547 1.0 0.6805596714342813 0.604607119874837 25.50967111067544 -13.999999999999988 0.20178679180545714 2.7879211674140123 0.5561394757357495 0.9994870928673556 0.003879895401835486 12.566827012479035 0.14242869293774793 8.874613992188985 0.047726240397451304 1.0000000000000286e-14 13.999999999999988 -2.231781691678263 TSEESWIEQQMLEDKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSEESWIEQQMLEDKK 16 1 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 142621700.0 99746000.0 22605000.0 20270700.0 True False 129123163.28760768 21347011.878608014 16581640.594946193 1.0 0.16532286953859615 0.12841724267560273 26.944172586720068 -13.23974441770576 0.4527438798147127 9.99989743170009 0.1285783374008317 0.9998899335233771 0.004222217581262287 17.65427270151554 0.22879874771154815 155.12748037745612 0.00828272136329894 5.757786833954509e-14 13.23974441770576 -9.871319094299258 TSEESWIEQQMLEDKK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 2 TSEESWIEQQMLEDKKR 17 2 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 688062300.0 240114600.0 345988000.0 101959700.0 True False 314792565.8730943 294367939.0506609 91409888.31050383 1.0 0.9351171881528251 0.2903813438445521 28.229826229726186 -6.9263003647145 0.776568430590923 1.01126565398595 0.16968738200805497 0.9957595958790694 0.020858817595732115 0.09460513261330783 0.0874313315852575 0.018600583046242194 0.05956837394445416 1.184948935872031e-07 6.9263003647145 -0.8415782719778949 down TSEESWIEQQMLEDKK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 2 TSEESWIEQQMLEDKKR 17 2 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 1040529100.0 528000400.0 323306000.0 189222700.0 True False 511239316.31480676 452403771.8185175 139659598.31067947 1.0 0.8849158454392816 0.2731785170933157 28.929423548574906 -6.938449910507564 0.6738321941361519 1.0070854856569273 0.11547372680984336 0.9979537051217913 0.014429392781224968 0.08848104768481613 0.05788421281436831 0.013886119892602916 0.053020710192781914 1.1522589483152043e-07 6.938449910507564 -0.891611758847084 down TSEESWIEQQMLEDKK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 2 TSEESWIEQQMLEDKKR 17 2 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 3698354000.0 1591438000.0 1467707000.0 639209000.0 True False 2414327795.702222 1205783218.602869 512869060.97474295 1.0 0.4994281309892138 0.2124272693574204 31.168974419527782 -8.715101287437413 0.24667985878400403 1.2722997353922971 4.050911798304633e-12 0.999291598927615 0.008661899041635267 0.273508656767232 0.0727592622037795 0.17548806989471608 0.11378504415581264 1.927075422574821e-09 8.715101287437413 -1.2722997353882461 TSEESWIEQQMLEDKK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TSEESWIEQQMLEDKKR 17 2 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 770038100.0 240114600.0 305147800.0 224775700.0 True False 328891456.4730792 291665361.2071666 171688309.06085393 1.0 0.8868134318078291 0.5220211886984883 28.293036291249077 -6.9498290578202315 0.560717350280064 1.004753197627061 0.3866259435457807 0.9991877983732372 0.00581230512595936 0.08355446005341892 0.036247026877710385 0.006225074653031059 0.03032886651078187 1.1224601776956876e-07 6.9498290578202315 -0.6181272540812802 TSEESWIEQQMLEDKK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSEESWIEQQMLEDKKR 17 2 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 110247700.0 73360400.0 32396000.0 4491300.0 True False 61002423.01675983 32221476.31789749 5430410.064575092 1.0 0.5281999423046679 0.089019579813791 25.86236321188441 -7.891261599342261 0.4572190153884079 1.035145945821132 6.361535898415628e-22 0.9961072483486413 0.02320889901479108 0.1062555756117983 0.09787006833039609 0.03754819039881348 0.07891163087540028 1.2845126945485152e-08 7.891261599342261 -1.035145945821132 down TSEESWIEQQMLEDKK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TSEESWIEQQMLEDKKR 17 2 H7BZQ3;A0A087WXV6;Q96G74-2;Q96G74-3;Q96G74-5;Q96G74;Q96G74-4 H7BZQ3 OTUD5 OTU domain-containing protein 5 1 4136476000.0 1591438000.0 1999701000.0 545337000.0 True False 2060147862.9328885 1888415881.4715452 446091261.6301439 1.0 0.9166409438122269 0.21653361375482774 30.94010074162023 -6.92920259675424 0.7533116581744843 1.0109676356590098 0.07568229283171773 0.9963791201547307 0.02114106696676838 0.09305412571932523 0.07972501124264207 0.01916990978864926 0.06362775494728722 1.1770567528457603e-07 6.92920259675424 -0.935285342827292 down TSEK(ub)LGEWNEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSEKLGEWNEK 11 1 O43399;O43399-5;O43399-7;A0A087WYR3 O43399 TPD52L2 Tumor protein D54 1 4847080.0 2209980.0 1229300.0 1407800.0 True False 2139825.3945818907 1720165.9007148123 1039054.9469052851 1.0 0.8038814312001016 0.4855793138712191 21.02906164975999 -6.963914705435687 0.37622025030127065 1.0228150510817202 0.25545703339327225 0.9998889859005347 0.0022334482654711523 0.07833127826600923 0.016170950395480516 0.004159972328095912 0.02694607605834056 1.086639016382598e-07 6.963914705435687 -0.767358017688448 down TSESLCQNNMVILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSESLCQNNMVILK 14 0 O14980;C9JKM9 O14980 XPO1 Exportin-1 0 6987300.0 1216800.0 3185700.0 2584800.0 False True 1595236.5835079614 2710405.9777613394 2317349.6911523873 1.0 1.6990620737903936 1.4526683471968045 20.605338969830093 -10.336001004018565 5.368718488792674 0.9998431454373368 1.5758652104936184 0.8792734397896319 0.10058981766292086 0.00018890367136004972 2.3363193536934972e-05 0.0974218290979036 0.03246522405053465 4.6131650807003024e-11 10.336001004018565 0.5760220650562816 TSESTGSLPSPFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSESTGSLPSPFLR 14 0 O95456;O95456-2 O95456 PSMG1 Proteasome assembly chaperone 1 0 8299100.0 1750000.0 3910000.0 2639100.0 False True 2294266.947024109 3326643.2410606276 2366031.2480347687 1.0 1.4499808949327422 1.0312798391241025 21.129601833712652 -10.40683372420588 3.4222870417958857 0.9977673075049286 1.2406303668729843 0.3057406654321474 0.17093399098761913 94377168.83429545 213336746.50126815 2315941.535803804 0.06756757791163352 3.9189188974980526e-11 10.40683372420588 0.24286305936805574 TSETLSQAGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSETLSQAGQK 11 0 P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;H0YC42 P55327-2 TPD52 Tumor protein D52 0 12134400.0 1428500.0 5774500.0 4931400.0 False True 1872777.3336136793 4912967.108824705 4421146.033329035 1.0 2.6233589122657346 2.3607430280021955 20.836747947929332 -10.144227394531297 4.8423503579715526 0.9998946769256144 2.492050970137136 0.9772929511617264 0.10721248582942632 0.00012398432103545822 2.1910910792911057e-05 0.10381534211264677 0.034602681005902115 7.174185559594351e-11 10.144227394531297 1.4921562932115213 TSETLSQAGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSETLSQAGQK 11 0 P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;H0YC42 P55327-2 TPD52 Tumor protein D52 0 8821500.0 3408500.0 1790800.0 3622200.0 False True 3300299.033218569 2505875.7788986294 2673437.156329255 1.0 0.7592874929441803 0.8100590671997452 21.65416531930925 -10.707573131668878 6.780512598595847 1.0022402364537637 0.7846732800719631 0.9599718777692506 0.020727408393993445 0.0007083841984604811 3.0550825074929884e-05 0.02025332179444718 0.006689742293331362 1.9607709697442442e-11 10.707573131668878 -0.21756695638180057 TSETLSQAGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSETLSQAGQK 11 0 P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;H0YC42 P55327-2 TPD52 Tumor protein D52 0 11928300.0 1428500.0 5893400.0 4606400.0 False True 1956655.053760969 5633010.101132356 3518463.1917859362 1.0 2.8788978876501043 1.7982031043350999 20.899958009452224 -10.600487066000062 6.147804012853048 0.9953171791829413 2.3385504959926022 0.6716480432217311 0.4411917978015654 0.028291861750784512 0.001838535590750409 0.4267935073983216 0.14239404044739778 2.5090709025876477e-11 10.600487066000062 1.3432333168096608 TSEVDLAKPLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSEVDLAKPLVK 12 1 Q8WUM4;Q8WUM4-2;A0A3B3IT07;Q8WUM4-3;C9IZF9;F8WEQ7;F8WBR8 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 0 4073290.0 994390.0 1243300.0 1835600.0 False True 1362042.8553793272 1188366.8949567091 1402069.085368675 1.0 0.8724886227061853 1.0293869093995582 20.377340666411715 -6.690591388404048 1.864696846705053 0.9201015327507567 1.0288430600058396 0.3730631540343313 0.05392198822057524 0.41537572860200184 2.8008027334708605 0.023131569218220138 0.06018286139256701 2.0389595570654908e-07 6.690591388404048 0.1087415272550829 TSEVNCYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSEVNCYR 8 0 P62633-2;P62633;P62633-7;P62633-3;P62633-8;P62633-5;P62633-4;P62633-6 P62633-2 CNBP Cellular nucleic acid-binding protein 0 24362500.0 3748500.0 10459000.0 10155000.0 False True 4914319.800525638 8898557.968862684 9104258.013638398 1.0 1.8107405154851521 1.8525977924075274 22.22856031380082 -11.138503144438209 0.5087106510889028 1.352983726099423e-16 1.8504055301445186 0.9998247764280523 0.005194604327806072 3.153903823134887 0.24844939037154398 3.6246954533530236 0.008377220382100715 7.269371359255538e-12 11.138503144438209 1.8504055301445184 TSEVNCYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSEVNCYR 8 0 P62633-2;P62633;P62633-7;P62633-3;P62633-8;P62633-5;P62633-4;P62633-6 P62633-2 CNBP Cellular nucleic acid-binding protein 0 10341900.0 5476400.0 2997600.0 1867900.0 False True 5302554.679629799 4194557.3122774875 1378640.954201154 1.0 0.7910446125885746 0.25999561296318485 22.338256162142525 -6.955108228538884 0.49962760385375227 1.0106696710851701 0.017480451469749546 0.9995435744257118 0.006654888652705469 0.08149707510632356 0.027957909047812254 0.0078099432263938505 0.04380619727573004 1.1088984373252804e-07 6.955108228538884 -0.9931892196154206 down TSEVNCYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSEVNCYR 8 0 P62633-2;P62633;P62633-7;P62633-3;P62633-8;P62633-5;P62633-4;P62633-6 P62633-2 CNBP Cellular nucleic acid-binding protein 0 28091220.0 6164620.0 17408000.0 4518600.0 False True 9352179.234090073 14301406.390675219 3625496.7294272636 1.0 1.5292057639939665 0.38766330698750867 23.1568711486436 -6.780646344866936 1.5333483007401645 1.2993967011572605 0.37843555238012727 0.7696755795354511 0.22385662883525462 0.24956939247106455 1.1590378056405661 0.11498156956610965 0.27116246788414666 1.6571188409190696e-07 6.780646344866936 -0.9209611487771332 down TSEVNCYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSEVNCYR 8 0 P62633-2;P62633;P62633-7;P62633-3;P62633-8;P62633-5;P62633-4;P62633-6 P62633-2 CNBP Cellular nucleic acid-binding protein 0 20537940.0 3748500.0 8077540.0 8711900.0 False True 5134421.749403563 7720647.573947234 6654328.647212549 1.0 1.5037034257741093 1.2960229938231203 22.29177037532371 -10.083631363498025 4.3268501819892595 0.9999606163112229 1.399863209696543 0.8317283240539045 0.08478518149511438 59387960.74598343 77504010.51849577 32427.728160231447 0.031028194700920886 8.248379543603652e-11 10.083631363498025 0.3999025933853202 TSEVNCYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSEVNCYR 8 0 P62633-2;P62633;P62633-7;P62633-3;P62633-8;P62633-5;P62633-4;P62633-6 P62633-2 CNBP Cellular nucleic acid-binding protein 0 7089600.0 5476400.0 1613200.0 0.0 False True 4553869.245655471 1604509.3714048716 0.0 1.0 0.3523397982793691 0.0 22.1186614375768 -8.486996673271957 0.5138551177699536 1.049582833524765 1.962319533560463e-19 0.9933800551783073 0.03369568606421021 0.21633067783557522 0.18362633288052393 0.07794374186123304 0.0670467353660009 3.2583919694494044e-09 8.486996673271957 -1.049582833524765 TSEVNCYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSEVNCYR 8 0 P62633-2;P62633;P62633-7;P62633-3;P62633-8;P62633-5;P62633-4;P62633-6 P62633-2 CNBP Cellular nucleic acid-binding protein 0 13431920.0 6164620.0 3133000.0 4134300.0 False True 7980222.11282711 2958645.7958716634 3381899.821500293 1.0 0.37074729926577443 0.4237851746086558 22.92799747073605 -10.43824016498319 9.357744050378766 1.0000033367278818 0.3972662387947176 0.9942261212410735 0.021652621938566836 1.5073495880271072e-06 9.047303988842402e-08 0.020965177148171633 0.006988353680816247 3.645522936421316e-11 10.43824016498319 -0.6027370979331641 TSEVPYAGINIGPVHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSEVPYAGINIGPVHK 16 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 26592800.0 5757300.0 10937000.0 9898500.0 False True 7547876.0537725035 9305242.232092088 8874298.17311665 1.0 1.2328292311373126 1.1757344860851535 22.847639301473457 -10.109617465081213 4.38962465312638 0.9999747777012824 1.2042818586247783 0.9446563479618063 0.023308832107804912 16240411.269301558 0.048057444265965726 4140.248969250054 0.007979233202304354 7.769311512053352e-11 10.109617465081213 0.20430708092349592 TSEVPYAGINIGPVHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSEVPYAGINIGPVHK 16 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 20056600.0 5038300.0 3183300.0 11835000.0 False True 4878361.924325987 4454408.290690198 8735058.4576105 1.0 0.9130950839211537 1.7905720389569841 22.217965364576116 -6.88254932026537 1.0655294761093888 0.9440919793730432 1.855867371838139 0.9756822067471493 0.061559591675608774 0.1253936002086193 0.2588703558900587 0.04439901224904533 0.1080938604765886 1.310541203472321e-07 6.88254932026537 0.9117753924650959 TSEVPYAGINIGPVHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSEVPYAGINIGPVHK 16 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 27211900.0 5757300.0 7004600.0 14450000.0 False True 7885929.3951823665 6695113.610885358 11037207.607091594 1.0 0.8489948711657886 1.3996077131801854 22.91084936299635 -6.833610900302157 1.311790744285782 0.9194942376658632 1.415537554476367 0.912888569856277 0.06856208127968426 0.17639779195427488 0.5923788496347068 0.04102196951567863 0.0944023707385516 1.4668614651742587e-07 6.833610900302157 0.49604331681050384 TSEVPYAGINIGPVHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSEVPYAGINIGPVHK 16 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 12138600.0 5038300.0 3442400.0 3657900.0 False True 4189569.684534727 3423855.107937101 4422749.977781325 1.0 0.8172331207607869 1.055657337341196 21.998370640010393 -6.701859995413748 1.8239764258498548 0.8867195538166213 1.0549799498376509 0.4265517864262679 0.0771218386322885 0.3916537513539742 2.5344084452267532 0.0337136166365072 0.0865123700747167 1.9867352829005662e-07 6.701859995413748 0.1682603960210296 TSEVPYAGINIGPVHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSEVPYAGINIGPVHK 16 0 A0A087WUT6;O60841 A0A087WUT6 EIF5B Eukaryotic translation initiation factor 5B 0 19916000.0 7368200.0 6593400.0 5954400.0 False True 9538280.148935815 6226471.4939355925 4870760.297303373 1.0 0.652787651097696 0.5106539356413015 23.18529772609135 -13.999999999999998 0.12280787804774118 2.652043196499132 0.292150837847899 0.9996792824768191 0.003680915776616476 11.953878745515759 0.10820325469331633 4.802786691158398 0.1939561331008126 1.0000000000000041e-14 13.999999999999998 -2.359892358651233 TSFEIAELK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSFEIAELKER 11 1 O95619;F8W0J4 O95619 YEATS4 YEATS domain-containing protein 4 1 3347380.0 481680.0 1578700.0 1287000.0 True False 400538.2620420948 1570195.2297525837 1556105.7495843396 1.0 3.9202128199866286 3.8850364548213867 18.611580539347315 -10.12420605935057 4.4327968261459505 0.9996212550270552 3.9026246375366207 0.9998898628848251 0.014360691442015381 1670039.9350546943 4.9814208681219005 6489.247131981722 0.004916046578067285 7.512663567030005e-11 10.12420605935057 2.9030033825095654 TSFFLGEVGNAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSFFLGEVGNAAK 13 0 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 0 7688200.0 3020400.0 2155000.0 2512800.0 False True 3959773.649595205 1833482.4001242055 2252799.56047962 1.0 0.46302707234582374 0.5689212969811839 21.916986533987732 -9.967435936039449 6.059506871402884 1.000000267941193 0.5159741846635753 0.9653461231985169 0.0432311361776187 1.5644418826693096e-07 2.6660320100044346e-08 0.04185839069100352 0.013952789204427161 1.0778642406542713e-10 9.967435936039449 -0.48402608327761776 TSFFLGEVGNAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSFFLGEVGNAAK 13 0 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 0 7868700.0 3020400.0 1563400.0 3284900.0 False True 4137123.5032408987 1494323.818527563 2509074.2746391147 1.0 0.36119874530140433 0.6064779725994598 21.980196595510623 -10.27167100557012 5.61856389759246 1.000041746755926 0.48383835895046495 0.8551684950699499 0.10013482523076477 5.2368456998351234e-05 6.788499711710195e-06 0.09696293983225902 0.03231837587450657 5.3496946545838945e-11 10.27167100557012 -0.516203387805461 TSFFLGEVGNAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSFFLGEVGNAAK 13 0 Q49A26-5;Q49A26-4;Q49A26-3;Q49A26;K7EMM8;Q49A26-2 Q49A26-5 GLYR1 Putative oxidoreductase GLYR1 0 6629020.0 2502400.0 945620.0 3181000.0 False True 2080856.4751165493 940525.7573691253 3846132.392717784 1.0 0.4519897304865518 1.8483410262605262 20.98874602945826 -6.800258276732939 1.454960291925761 0.6977400638139514 1.8677182137098396 0.832895266572834 0.2348206763438658 0.22038570235259547 0.9210478120390475 0.12696887864468132 0.29522294556340795 1.5839509301055552e-07 6.800258276732939 1.169978149895888 TSFFQALGITTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSFFQALGITTK 12 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 555427900.0 129520000.0 160940700.0 264967200.0 False True 169801974.273464 136928974.90193513 237550935.88885528 1.0 0.806403903651984 1.3989880677493327 27.339277992182886 -6.818707456254928 1.3773905058501184 0.8955130338389021 1.4115763483964006 0.8813954561795292 0.08496715801424085 0.19516919517205267 0.7279092886787348 0.0484787294077505 0.11177966441618287 1.5180726072588312e-07 6.818707456254928 0.5160633145574984 TSFFQALGITTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSFFQALGITTK 12 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 813121360.0 327760000.0 185911360.0 299450000.0 False True 317355438.206753 260146735.56293476 221015061.69256103 1.0 0.8197330319370563 0.696427522847655 28.241524323971653 -7.479166940783657 0.06820199545691569 1.5752516647704546 5.125375606090104e-08 0.9999994816162888 8.956650138023754e-05 0.13200583476122277 0.0055862477101241235 0.055622583159514946 0.07137788416241446 3.3176690338034974e-08 7.479166940783657 -1.5752516135166985 TSFFQALGITTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSFFQALGITTK 12 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 869530000.0 312530000.0 326660000.0 230340000.0 False True 474130859.0035017 268364970.79377088 184813198.03839144 1.0 0.5660145626416374 0.38979364985189985 28.82071005362383 -13.999999999873548 0.12405778550530626 3.0638151544508063 0.1233187301884413 0.9996732861015561 0.00463479964355646 11.95003728914794 0.10890062832967934 6.050166356135158 0.2365893016655763 1.0000000002911659e-14 13.999999999873548 -2.9404964242623652 TSFFQALGITTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSFFQALGITTK 12 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 793310560.0 129520000.0 292880560.0 370910000.0 False True 177407044.1463915 279940128.4327044 283308697.1312349 1.0 1.5779538505906527 1.5969416462260437 27.402488053705778 -11.405290851667319 0.5560764689628103 4.3279948039060684e-13 1.5951882087146658 0.9999157038512595 0.0025435238586836387 4.0597834600631035 0.27423027324041704 4.948426616702329 0.00351441130063884 3.932865989903229e-12 11.405290851667319 1.595188208714233 TSFFQALGITTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSFFQALGITTK 12 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 629601400.0 327760000.0 140230000.0 161611400.0 False True 272546962.2299388 139474553.15652445 195403596.5333135 1.0 0.51174502924327 0.7169538597478772 28.02192959940593 -10.24296879754612 5.556493770832991 1.0000239747893775 0.6143494444955585 0.8248399299414999 0.08377615424164869 2.4883141719321512e-05 3.3900217470062544e-06 0.08112094655881369 0.027038637515592896 5.715196967753866e-11 10.24296879754612 -0.38567453029381904 TSFFQALGITTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSFFQALGITTK 12 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 0 993620000.0 312530000.0 480610000.0 200480000.0 False True 404576245.88731396 453863631.0098555 163994697.09851223 1.0 1.1218247131994732 0.40534929760604244 28.59183637571628 -6.863134405245883 1.1699004027694706 1.066723557461279 0.36853603702329796 0.9573313003013133 0.06465698894794156 0.14360253609428364 0.37172289165454725 0.043049786379312 0.10086554273821005 1.3704575719830207e-07 6.863134405245883 -0.698187520437981 down TSFFQALGITTK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSFFQALGITTK 12 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 7702800.0 2297300.0 3698300.0 1707200.0 True False 3011782.547084845 3146528.0558604943 1530555.3206187566 1.0 1.0447394546814384 0.5081891858694138 21.522186179451083 -6.886660975937015 1.041974120226033 1.0311793824785842 0.4649572177920778 0.9786720675674793 0.0354987673361655 0.12189237472598509 0.23802913969981485 0.026066462392151643 0.06424764656065789 1.2981922856572599e-07 6.886660975937015 -0.5662221646865064 TSFFQALGITTK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSFFQALGITTK 12 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 11837200.0 3067000.0 3950500.0 4819700.0 True False 2969639.763790922 5527955.25158534 3557275.982099309 1.0 1.8614901776936663 1.1978813139133868 21.50185650287101 -10.231048850277404 4.818896433092606 0.9998956501721297 1.5296857458045428 0.45930621922413506 0.27091718417880134 0.0003038037553472645 4.8478032405565596e-05 0.26236575592234956 0.0874381452099466 5.874232743154805e-11 10.231048850277404 0.5297900956324131 TSFFQALGITTK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSFFQALGITTK 12 0 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 5537700.0 3067000.0 0.0 2470700.0 True False 2550346.391137488 0.0 2987311.946773913 1.0 0.0 1.1713357672333806 21.282261778305287 -10.762558407076328 6.173389073424045 1.01417520221547 0.5856678836166904 0.1429768364993741 0.47819582453220505 0.0927229352166704 0.0035663152323594225 0.4601697928228797 0.15433703871992946 1.7275936255450638e-11 10.762558407076328 -0.42850731859877955 TSFFQALGITTK(ub)ISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSFFQALGITTKISR 15 1 P05388;F8VWS0;P05388-2;F8VU65;F8VW21;G3V210;F8VPE8;Q8NHW5 P05388 RPLP0;RPLP0P6 60S acidic ribosomal protein P0;60S acidic ribosomal protein P0-like 1 6191000.0 1871000.0 2275400.0 2044600.0 True False 1811606.1291336205 3183979.0860542464 1509057.9233147798 1.0 1.7575448850887623 0.8329944898323286 20.788837894844775 -6.6889716731358435 1.8704966874948947 1.4753975410279743 0.8362647307115663 0.36547074508177635 0.3204560979802184 0.4188564522052763 2.840605280304122 0.13710973416134062 0.35745055675121457 2.0465781204602757e-07 6.6889716731358435 -0.639132810316408 TSFLLNLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSFLLNLR 8 0 F5H6E2;O00159-2;O00159-3;O00159 F5H6E2 MYO1C Unconventional myosin-Ic 0 8230600.0 1419200.0 3349200.0 3462200.0 False True 1860584.9435523483 2849512.4150793455 3103964.755767491 1.0 1.5315142826206436 1.6682736074608893 20.82732482640666 -11.555581521323653 0.2379752332814474 5.294463014625109e-16 1.7386772795327952 0.9993194606063549 0.007519656963592924 4.110356212860377 0.1357548349779177 2.1702862382725363 0.06727498932640984 2.782393042432101e-12 11.555581521323653 1.7386772795327947 TSFLLNLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSFLLNLR 8 0 F5H6E2;O00159-2;O00159-3;O00159 F5H6E2 MYO1C Unconventional myosin-Ic 0 3738500.0 2027900.0 1710600.0 0.0 False True 1963525.424516339 2393651.500661157 0.0 1.0 1.219058062999499 0.0 20.905014848044637 -6.908789586150892 1.2809127660968092 1.1144668004486182 1.645910408072381e-20 0.9526937470591782 0.11541146425347056 0.12890438466435716 0.42400362682850457 0.0738123472056589 0.1457739324741721 1.2337024120826235e-07 6.908789586150892 -1.1144668004486182 down TSFLLNLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSFLLNLR 8 0 F5H6E2;O00159-2;O00159-3;O00159 F5H6E2 MYO1C Unconventional myosin-Ic 0 18241400.0 7543000.0 4703800.0 5994600.0 False True 11443282.467166094 3864370.1390428543 4809764.682473488 1.0 0.3376976973286108 0.42031337566594357 23.447997607922428 -10.63578734580993 6.60945485417689 1.0024313116601038 0.37900553649966895 0.9868996243379174 0.03372770944672849 0.0012114245110993052 6.675516056250395e-05 0.032739638183430786 0.010885571416075168 2.313197180016432e-11 10.63578734580993 -0.6234257751604348 TSFLLNLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSFLLNLR 8 0 F5H6E2;O00159-2;O00159-3;O00159 F5H6E2 MYO1C Unconventional myosin-Ic 0 9733800.0 1419200.0 3184500.0 5130100.0 False True 1943916.5924379157 3043798.260266735 3918476.0377259892 1.0 1.565807026961702 2.0157634607211863 20.89053488792955 -6.973711733521454 0.1441620903153034 0.4320824725792866 3.1612644499120104 0.9999987774829008 0.0004594620695075789 0.0751155941500076 0.0043823253977904545 0.024360532632421345 0.057527202929598314 1.0624005001505457e-07 6.973711733521454 2.7291819773327237 TSFLLNLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSFLLNLR 8 0 F5H6E2;O00159-2;O00159-3;O00159 F5H6E2 MYO1C Unconventional myosin-Ic 0 6149200.0 2027900.0 1774100.0 2347200.0 False True 1686288.7012023847 1764542.5711687214 2837988.667773398 1.0 1.0464059742027203 1.6829791160610932 20.685420123478913 -6.92155458521679 0.8131127248192551 0.9867260569069315 1.7893953137516048 0.9946020162124649 0.022893401180567256 0.09726559745592182 0.10093719882866807 0.019889166829255785 0.06049254852295444 1.19796854452732e-07 6.92155458521679 0.8026692568446733 TSFLLNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSFLLNLR 8 0 F5H6E2;O00159-2;O00159-3;O00159 F5H6E2 MYO1C Unconventional myosin-Ic 0 25228300.0 7543000.0 12293000.0 5392300.0 False True 9764562.194758948 11608883.743584523 4410956.729670332 1.0 1.1888790825476538 0.4517311315849755 23.219123930014877 -6.838739729600093 1.2883403222676502 1.1004990186308052 0.42809981030360633 0.9222481066583211 0.08717499675271771 0.1702766379798646 0.5495701437475077 0.05307030249072214 0.12221843515978509 1.4496403551185798e-07 6.838739729600093 -0.6723992083271989 down TSFQMAGEWLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSFQMAGEWLK 11 0 Q9HAV4 Q9HAV4 XPO5 Exportin-5 0 6623400.0 1620400.0 2504500.0 2498500.0 False True 2124360.0919759213 2130838.3624645364 2239979.187304337 1.0 1.0030495161875261 1.05442537532367 21.018596901792034 -6.919070319667825 0.8315912767124123 0.9988279826936841 1.0625356258539083 0.9939186947868192 0.0019471145837368531 0.09872208476157086 0.10847120409312688 0.0016694286602541375 0.004957154135637137 1.204840840340125e-07 6.919070319667825 0.06370764316022415 TSFQMAGEWLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSFQMAGEWLK 11 0 Q9HAV4 Q9HAV4 XPO5 Exportin-5 0 5153900.0 1620400.0 1329800.0 2203700.0 False True 2219505.6696634735 1271045.0389394592 1683231.4466261426 1.0 0.57267032759244 0.7583812330974392 21.081806963314925 -10.23947425546987 5.534876672346353 1.0000206512548908 0.665525780344924 0.8122076634411006 0.07581615969296693 1.9321639199520194e-05 2.6549348174714803e-06 0.073413207908922 0.024469560322013924 5.761369703545362e-11 10.23947425546987 -0.33449487090996677 TSFVNFTDICK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSFVNFTDICK 11 0 P20042 P20042 EIF2S2 Eukaryotic translation initiation factor 2 subunit 2 0 18657200.0 4703500.0 6330700.0 7623000.0 False True 6166334.048758799 5386184.236875324 6834245.084979373 1.0 0.8734823955830759 1.1083157401041248 22.555981615991723 -6.7603761322690366 1.611089280623313 0.9265459386741861 1.1091886944306746 0.6924935448100403 0.05321642254408005 0.28228324385567255 1.4441661721169123 0.02606110773302675 0.06260482466607101 1.7362964117573392e-07 6.7603761322690366 0.18264275575648847 TSGHLLLGVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSGHLLLGVVR 11 0 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7;Q9H4I0;A0A140T8W2;Q9H4I0-2 O60216 RAD21;RAD21L1 Double-strand-break repair protein rad21 homolog;Double-strand-break repair protein rad21-like protein 1 0 19499400.0 3900600.0 6055700.0 9543100.0 False True 5113724.373464128 5152213.164933715 8555671.55587913 1.0 1.0075265674601688 1.673080309192215 22.285942971641582 -6.909371031723577 0.9000114630872639 0.9789807828211315 1.7579435367221152 0.9906818843211058 0.030458621899941574 0.10483548048946845 0.1410359799495805 0.024859552895192774 0.06832786261105286 1.2320518020510388e-07 6.909371031723577 0.7789627539009837 TSGHLLLGVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSGHLLLGVVR 11 0 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7;Q9H4I0;A0A140T8W2;Q9H4I0-2 O60216 RAD21;RAD21L1 Double-strand-break repair protein rad21 homolog;Double-strand-break repair protein rad21-like protein 1 0 10107500.0 4446000.0 1852200.0 3809300.0 False True 4304864.163617359 2591793.119095401 2811530.053449569 1.0 0.6020615333231626 0.6531054050929803 22.03753628463098 -10.079980604479434 6.601455738998175 1.000000314438339 0.627583469208572 0.986106412601382 0.020838573388687536 9.64467581843817e-08 1.3435590715109202e-08 0.020176878910030498 0.006725620641091905 8.318009183662051e-11 10.079980604479434 -0.3724168452297669 TSGHLLLGVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSGHLLLGVVR 11 0 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7;Q9H4I0;A0A140T8W2;Q9H4I0-2 O60216 RAD21;RAD21L1 Double-strand-break repair protein rad21 homolog;Double-strand-break repair protein rad21-like protein 1 0 15421300.0 3900600.0 3127600.0 8393100.0 False True 5342757.229751505 2989412.2904098798 6410822.641320456 1.0 0.5595261326423622 1.1999090292969623 22.349153033164473 -6.721613106892991 1.7533057522986655 0.7324767642716008 1.1990126066187867 0.5201031467774695 0.18531885285635843 0.35224813703348273 2.1170343368286137 0.08389236201129152 0.21021900019543302 1.89839636269511e-07 6.721613106892991 0.4665358423471859 TSGHLLLGVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSGHLLLGVVR 11 0 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7;Q9H4I0;A0A140T8W2;Q9H4I0-2 O60216 RAD21;RAD21L1 Double-strand-break repair protein rad21 homolog;Double-strand-break repair protein rad21-like protein 1 0 9857800.0 4446000.0 2427200.0 2984600.0 False True 3697045.9911957197 2414124.1918385215 3608666.060768786 1.0 0.652987330313879 0.9760944465831897 21.817941560065258 -10.48857026225001 8.654861097208228 1.0000069485604024 0.8145408889645042 0.30520845675106834 0.13190792785365468 1.768657764254107e-05 1.0452420956508888e-06 0.1277240842098461 0.042573100650827846 3.24660712747131e-11 10.48857026225001 -0.18546605959589824 TSGHLLLGVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSGHLLLGVVR 11 0 O60216;E5RJW1;E5RJK5;E5RFV8;E5RIN7;Q9H4I0;A0A140T8W2;Q9H4I0-2 O60216 RAD21;RAD21L1 Double-strand-break repair protein rad21 homolog;Double-strand-break repair protein rad21-like protein 1 0 22388100.0 4490200.0 10267000.0 7630900.0 False True 5812652.415074457 9695632.42458166 6242154.499646028 1.0 1.6680220546883437 1.0738908941910417 22.47076521021099 -10.238749422080508 4.613276265837768 0.9998858532023761 1.3709564744417766 0.3420102460697111 0.24255303059145347 0.0002848489082934072 4.7004083922962505e-05 0.23492287543832735 0.07828365400339868 5.770993403875975e-11 10.238749422080508 0.3710706212394005 TSGHVDK(ub)FADFMVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSGHVDKFADFMVK 14 1 P41250 P41250 GARS Glycine--tRNA ligase 1 16760600.0 5204300.0 6396500.0 5159800.0 True False 6822887.698512895 5442167.13336171 4625913.392296546 1.0 0.797633989278158 0.6779993452486112 22.701951039744092 -13.999999992473883 0.05587823334415517 2.350856380273685 0.08149784823425384 0.9999640220212556 0.0007971030289844314 12.50614734284621 0.05883967995666548 2.4531417371543514 0.5638198259086651 1.000000017329524e-14 13.999999992473883 -2.269358532039431 TSGHVDK(ub)FADFMVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSGHVDKFADFMVK 14 1 P41250 P41250 GARS Glycine--tRNA ligase 1 23062400.0 5302900.0 8727900.0 9031600.0 True False 5134562.342160705 12212995.985397236 6665953.017807763 1.0 2.378585587541589 1.2982514523336424 22.29180987922628 -6.58491735507436 2.2476014391156633 1.9359908298111916 1.3011300139867226 0.0 0.5981576660838612 0.6847511373021107 6.513260102502031 0.22278763888637557 0.6678360180912567 2.600654412744209e-07 6.58491735507436 -0.6348608158244691 TSGHVDK(ub)FADFMVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSGHVDKFADFMVK 14 1 P41250 P41250 GARS Glycine--tRNA ligase 1 47434000.0 11032000.0 16063000.0 20339000.0 True False 16736350.547232708 13196432.149208155 16318987.735099627 1.0 0.7884892295943297 0.9750624957958896 23.996481638849865 -10.25363097021206 6.699803911797806 1.0000011808099376 0.8817758627330861 0.3486902437289988 0.0761682169730461 1.343437734000295e-06 1.4976036810169496e-07 0.07375029524307215 0.024583186320576707 5.5765940340204336e-11 10.25363097021206 -0.11822531807685155 TSGHVDK(ub)FADFMVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSGHVDKFADFMVK 14 1 P41250 P41250 GARS Glycine--tRNA ligase 1 17846300.0 5204300.0 5703700.0 6938300.0 True False 7128470.350919293 5451691.674386368 5299616.438773948 1.0 0.7647772111001785 0.743443709223046 22.765161101266983 -13.999999999999998 0.3396837093685861 3.7153548250944253 0.7400808313946072 0.9997345696985006 0.0018937798689355628 19.675001838826073 0.18693618465351822 38.355861376875076 0.006598752714575397 1.0000000000000041e-14 13.999999999999998 -2.975273993699818 TSGHVDK(ub)FADFMVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSGHVDKFADFMVK 14 1 P41250 P41250 GARS Glycine--tRNA ligase 1 18507800.0 5302900.0 8212200.0 4992700.0 True False 4409596.308302245 8167959.248605935 6036650.486363429 1.0 1.8523145153282095 1.3689803021192255 22.072215154660558 -10.420587560612454 5.280325785389536 0.999467519055893 1.6106474087237292 0.6803334833044041 0.19732036626530522 0.0012379369809834204 0.0001358390683405932 0.1912131198985412 0.06368487436775029 3.796753827129111e-11 10.420587560612454 0.6111798896678362 TSGHVDK(ub)FADFMVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSGHVDKFADFMVK 14 1 P41250 P41250 GARS Glycine--tRNA ligase 1 43629000.0 11032000.0 13457000.0 19140000.0 True False 14281141.473230902 12708106.120346284 15656716.392984439 1.0 0.8898522673531962 1.0963210764582065 23.767607960942314 -6.761784083655262 1.6058168190073205 0.9361624073644742 1.0971411762515288 0.698198271162763 0.04634085602391055 0.279923534514168 1.4230442732688635 0.022765308842217034 0.05461131976937246 1.7306765784923963e-07 6.761784083655262 0.16097876888705465 TSGLCVPLTWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSGLCVPLTWR 11 0 Q9NPF0;M0R100 Q9NPF0 CD320 CD320 antigen 0 4423300.0 0.0 1805200.0 2618100.0 False True 0.0 1725440.2950018898 1999758.7014620434 0.0 TSGLQQK(ub)NVEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSGLQQKNVEVK 12 1 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;Q9UBU8-3;H0YM21;H0YNE0;H0YMT8;H0YLV1;H0YNI8;H0YNX3 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 1 45938000.0 21313000.0 21918300.0 2706700.0 True False 20636430.48114638 30670391.49242453 1997734.0707405412 1.0 1.4862256105989484 0.09680618324790657 24.298690111111203 -6.812129571202147 1.4054293699716265 1.264314640995834 0.07125069234829756 0.865391359831031 0.21121129724250404 0.203877895012228 0.7932648424488905 0.11815328967409597 0.27307584494549736 1.5412405572031078e-07 6.812129571202147 -1.1930639486475363 down TSGNVEDDLIIFPDDCEFK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSGNVEDDLIIFPDDCEFKR 20 1 Q16186 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 13851100.0 2430400.0 5230100.0 6190600.0 True False 3186277.936027079 4449789.466770121 5550056.096428349 1.0 1.3965478078533522 1.7418618864582254 21.60344068660768 -6.972745573670929 0.18096170155720862 0.7364321839963561 2.41132439306204 0.9999966354198673 0.0005559482956906815 0.07542145578037061 0.005713118576690605 0.013185114264858154 0.03863917881529863 1.0647666165779505e-07 6.972745573670929 1.6748922090656837 TSGNVEDDLIIFPDDCEFK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSGNVEDDLIIFPDDCEFKR 20 1 Q16186 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 22538000.0 9064600.0 6404600.0 7068800.0 True False 8776849.234711181 8961990.179547772 5217269.220545588 1.0 1.0210942377937158 0.5944353242291135 23.06527169481811 -6.895273547910958 0.9906912533954287 1.0201117377940898 0.5537152934628653 0.984063668746768 0.02478654848485051 0.114967546560445 0.19770068418563766 0.018919393488600875 0.04815435469054766 1.2727011955832384e-07 6.895273547910958 -0.4663964443312245 TSGNVEDDLIIFPDDCEFK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSGNVEDDLIIFPDDCEFKR 20 1 Q16186 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 189099000.0 23626000.0 69989000.0 95484000.0 True False 35842369.291961506 57498916.123447046 76611545.54787613 1.0 1.6042163857829155 2.1374576251871296 25.095162671383424 -6.972596683636001 0.1859797770471139 0.6190516583352192 3.1371294588095964 0.9999961908600866 0.0009068718102849528 0.07546875568431705 0.00590533465295016 0.019487429986931305 0.0587925381754176 1.0651317152001058e-07 6.972596683636001 2.5180778004743773 TSGNVEDDLIIFPDDCEFK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSGNVEDDLIIFPDDCEFKR 20 1 Q16186 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 17843700.0 2430400.0 3974300.0 11439000.0 True False 3328984.5590904127 3798702.284747403 8737343.79360006 1.0 1.1410994005287103 2.624627311574971 21.66665074813057 -6.925389357953749 0.7836983991425343 0.9731751894697315 2.896280464970318 0.9955521932059413 0.04900921960111105 0.09510332632136995 0.08992897907328938 0.04348075155665968 0.13779268566913444 1.1874371772447824e-07 6.925389357953749 1.9231052755005869 up TSGNVEDDLIIFPDDCEFK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSGNVEDDLIIFPDDCEFKR 20 1 Q16186 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 32404200.0 9064600.0 3033600.0 20306000.0 True False 7537616.52986791 3017257.3946775487 24551890.715664018 1.0 0.4002932999737549 3.257248576970825 22.845676970252388 -6.851902468743997 1.2259585949729923 0.6793977129664206 3.3756627978377933 0.9430172754755535 0.2936238115406376 0.1553775497391273 0.448444208276559 0.18732212501894982 0.4340121484342378 1.4063633213279328e-07 6.851902468743997 2.6962650848713725 up TSGNVEDDLIIFPDDCEFK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSGNVEDDLIIFPDDCEFKR 20 1 Q16186 Q16186 ADRM1 Proteasomal ubiquitin receptor ADRM1 1 194425000.0 23626000.0 80288000.0 90511000.0 True False 30584322.738084912 75819902.2211758 74038926.72128612 1.0 2.479044668422937 2.420813020949771 24.866288993475873 -10.070324699471117 6.2015855753649785 0.9999975118007928 2.449928844686378 0.9987917383109498 0.023772970531900056 8.178876296111012e-07 1.226178345102426e-07 0.02301811915485443 0.007672693246648096 8.505019242369437e-11 10.070324699471117 1.4499313328855852 TSGQTFANSNSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSGQTFANSNSSR 13 0 Q99661;Q99661-2 Q99661 KIF2C Kinesin-like protein KIF2C 0 4087440.0 703140.0 1927500.0 1456800.0 False True 921823.349217446 1639924.5133361532 1306064.3106123512 1.0 1.7790008408100286 1.416827108709163 19.81413078515064 -10.111146540674614 4.39499529806301 0.9999368316486458 1.597913974443643 0.7842026683176038 0.14785680724565523 21626583.31541952 16584749.315200206 13711.856297290395 0.05061531875011263 7.742005211477696e-11 10.111146540674614 0.5979771427949973 TSGQTFANSNSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSGQTFANSNSSR 13 0 Q99661;Q99661-2 Q99661 KIF2C Kinesin-like protein KIF2C 0 2741540.0 1192100.0 569890.0 979550.0 False True 1154257.438022548 797450.0489370889 722976.4691298989 1.0 0.6908771151635507 0.6263563441865174 20.138533598452774 -13.999999999999996 0.22021867813385124 2.8671706185522554 0.5919162756763428 0.9994981113817218 0.0036532548171951634 13.005609742436464 0.14866185917764974 10.56156123027671 0.03565603069394342 1.0000000000000082e-14 13.999999999999996 -2.275254342875913 TSGQTFANSNSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSGQTFANSNSSR 13 0 Q99661;Q99661-2 Q99661 KIF2C Kinesin-like protein KIF2C 0 9023500.0 1555900.0 6358300.0 1109300.0 False True 2360414.051526408 5223611.687375357 890046.3687765386 1.0 2.213006520613367 0.3770721362215975 21.170608521152282 -6.7285211581947575 1.7285080192985252 1.731175253063951 0.3784325993675798 0.55244904555623 0.5099811380963511 0.3390164202789674 1.9836424066144465 0.2338686242820272 0.5813285873811533 1.8684386474282872e-07 6.7285211581947575 -1.3527426536963714 TSGQTFANSNSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSGQTFANSNSSR 13 0 Q99661;Q99661-2 Q99661 KIF2C Kinesin-like protein KIF2C 0 4748340.0 703140.0 2033900.0 2011300.0 False True 963109.859644023 1944035.5727921263 1536272.3640237597 1.0 2.0184982567935346 1.5951164331258996 19.87734084667353 -10.130181358046608 4.6709049828866425 0.9999301899838078 1.806807344970509 0.8288222226192387 0.1728449057627553 0.00012566825565226932 2.3402278101302658e-05 0.1673707455728933 0.05578545350388589 7.41000740453668e-11 10.130181358046608 0.8068771549867013 TSGQTFANSNSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSGQTFANSNSSR 13 0 Q99661;Q99661-2 Q99661 KIF2C Kinesin-like protein KIF2C 0 3505530.0 1555900.0 646330.0 1303300.0 False True 2014143.2213741778 610361.1673302688 1066112.7729872854 1.0 0.30303761959581066 0.5293132889824562 20.94173484324473 -10.116181206979858 5.147597946212966 1.0000164717046374 0.4161754542884943 0.8987466153496699 0.092376655203712 1.7463028727488354e-05 2.998188362626344e-06 0.08944583265863053 0.02981443726475546 7.652772325782489e-11 10.116181206979858 -0.583841017416143 TSGSVYITLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSGSVYITLK 10 0 P37108;H0YLA2 P37108 SRP14 Signal recognition particle 14 kDa protein 0 84432500.0 20465200.0 21729000.0 42238300.0 False True 26830075.38527873 18487117.898978606 37867885.894383326 1.0 0.6890445752948654 1.4113969249285405 24.677347772399795 -6.789724595962607 1.4973837438734479 0.8261389994482129 1.4190250251682313 0.8004160951716351 0.1321694838732552 0.23577948170681262 1.0443745276589222 0.06947619526902413 0.16269693162909793 1.6228388801729254e-07 6.789724595962607 0.5928860257200184 TSGSVYITLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSGSVYITLK 10 0 P37108;H0YLA2 P37108 SRP14 Signal recognition particle 14 kDa protein 0 84484400.0 27606000.0 23579400.0 33299000.0 False True 26729662.640760437 32994777.38494661 24576992.95141292 1.0 1.2343880964151195 0.919465138102234 24.671938293428394 -6.7074433376284714 1.8046121781524196 1.1444724846504961 0.9202680218403211 0.45285804851449996 0.09881017677885719 0.38021609478487445 2.4121416022339854 0.04360243798313388 0.11110327038557138 1.9613570569051406e-07 6.7074433376284714 -0.22420446281017503 TSGSVYITLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSGSVYITLK 10 0 P37108;H0YLA2 P37108 SRP14 Signal recognition particle 14 kDa protein 0 471400000.0 122780000.0 164140000.0 184480000.0 False True 186266236.42034385 134847934.56832653 148017447.13954365 1.0 0.7239526452019865 0.7946552739999277 27.472790946725585 -10.73926302961826 11.322794806732007 1.0002686567345758 0.7593039596009574 0.9392198490462673 0.02886422733806059 0.00019596419397628902 4.512575768840916e-06 0.027977490900915735 0.009315889315121124 1.8227913978367197e-11 10.73926302961826 -0.24096469713361834 TSGSVYITLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSGSVYITLK 10 0 P37108;H0YLA2 P37108 SRP14 Signal recognition particle 14 kDa protein 0 93479200.0 20465200.0 32050000.0 40964000.0 False True 28031737.491234846 30633925.024823062 31289146.88006229 1.0 1.0928300478841844 1.1162043340997323 24.740557833922686 -13.999999986307701 0.19366657567311174 0.49590889771499663 1.1323684066554989 0.9994877944244033 0.0011357805834679476 12.41300625625207 0.13956014902037442 2.3643393375554678 0.01561858284118608 1.0000000315276837e-14 13.999999986307701 0.6364595089405023 TSGSVYITLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSGSVYITLK 10 0 P37108;H0YLA2 P37108 SRP14 Signal recognition particle 14 kDa protein 0 55125000.0 27606000.0 14204000.0 13315000.0 False True 22955612.153159946 14127480.232726756 16099104.938395884 1.0 0.6154259855266828 0.7013145557165971 24.45234356886267 -9.946274793295867 5.84640953584122 1.0000002360731317 0.6583702706214795 0.9547408680234604 0.0350638619510011 1.0785590290336159e-07 1.946970523048771e-08 0.03395046161833172 0.0113168127824101 1.1316840805844912e-10 9.946274793295867 -0.34162996545165225 TSGSVYITLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSGSVYITLK 10 0 P37108;H0YLA2 P37108 SRP14 Signal recognition particle 14 kDa protein 0 472148500.0 122780000.0 214218500.0 135150000.0 False True 158941130.35562828 202297052.16180426 110554086.7561049 1.0 1.2727797500191913 0.6955662546802195 27.243917268818034 -6.778189107027249 1.5428351230599056 1.1548182966229117 0.6912438035473335 0.7609543550111977 0.11527067573900107 0.2534017383156324 1.1912602712251705 0.05885242238347602 0.13908397655535773 1.666521392759661e-07 6.778189107027249 -0.4635744930755782 TSGVPSGFNFTAPPVLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSGVPSGFNFTAPPVLGK 18 0 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A0A0MSW3;E9PKD2;B7ZAV2;H0Y837 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 0 7480900.0 1588900.0 2614200.0 3277800.0 False True 2083063.2869294856 2224171.550071786 2938644.6988777895 1.0 1.0677407470179647 1.4107323177921605 20.990275240844994 -6.9395251798798 0.6639683363623171 0.9961168105035695 1.5019477686142149 0.9981010200531083 0.007834934259659358 0.08798393736934644 0.05560157830389797 0.007599553151436827 0.029582896023273127 1.1494096000803401e-07 6.9395251798798 0.5058309581106454 TSGVPSGFNFTAPPVLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSGVPSGFNFTAPPVLGK 18 0 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A0A0MSW3;E9PKD2;B7ZAV2;H0Y837 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 0 6847900.0 1588900.0 2663900.0 2595100.0 False True 2176359.2684079795 2546200.089660721 1982190.8277621712 1.0 1.1699355555037942 0.9107829100349577 21.053485302367886 -6.729790592785941 1.7238385587010632 1.102289799659233 0.910938738196006 0.5583498256835773 0.07143814715216365 0.33663777294622765 1.9596727574544173 0.0328407973215307 0.08151636162416905 1.8629852104811817e-07 6.729790592785941 -0.1913510614632269 TSGVVTSCTGVLPQLSMVK ddPTM_RPMI8226_Bortezomib_1h_R1 2 TSGVVTSCTGVLPQLSMVK 19 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 64624300.0 13702600.0 30595300.0 20326400.0 False True 17964241.296167172 26030600.49954531 18223219.112596717 1.0 1.4490230937333917 1.0144162958045324 24.09862466988999 -10.518219757719919 3.153013261193251 0.9929896351947264 1.2317196948146862 0.27485169409860466 0.1774274834036008 40052053.416885845 39550636.442228265 2338939.131679821 0.06264921705057155 3.032356390681316e-11 10.518219757719919 0.23873005961995986 TSGVVTSCTGVLPQLSMVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSGVVTSCTGVLPQLSMVK 19 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 22788800.0 11763000.0 3705000.0 7320800.0 False True 11389590.003740672 5184425.821319762 5403262.860707645 1.0 0.45518985491286745 0.4744036316437253 23.441212478841738 -10.340859040092749 8.954895405068763 1.0000006698543693 0.4647967432984851 0.9990343274322037 0.007843991503727062 1.049064324705568e-07 7.70927050274474e-09 0.007594921733687193 0.0025316373718106133 4.561849568714724e-11 10.340859040092749 -0.5352039265558842 TSGVVTSCTGVLPQLSMVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSGVVTSCTGVLPQLSMVK 19 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 51808800.0 6988000.0 35309000.0 9511800.0 False True 10601306.891231159 29007833.079523843 7631788.56082996 1.0 2.7362506695771245 0.7198912963403193 23.337738790252644 -6.678856495524312 1.905741968837186 2.099691547181792 0.727608751698432 0.3188773159926839 0.7360536682747294 0.4411362222177353 3.0965282546165147 0.3100108616982522 0.8188950742492579 2.0948045304171078e-07 6.678856495524312 -1.3720827954833599 TSGVVTSCTGVLPQLSMVK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TSGVVTSCTGVLPQLSMVK 19 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 45410200.0 13702600.0 14421000.0 17286600.0 False True 18768821.51884148 13783832.53613022 13203861.108702399 1.0 0.7344005334747857 0.7034997426688416 24.16183473141288 -13.999999999999998 0.3035764944395503 3.4731990823814933 0.6961746449943106 0.999657793438757 0.0024619541408865816 16.825154503494442 0.1750909395390139 26.19081447193116 0.010998359548531336 1.0000000000000041e-14 13.999999999999998 -2.777024437387183 TSGVVTSCTGVLPQLSMVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSGVVTSCTGVLPQLSMVK 19 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 21131900.0 11763000.0 2895100.0 6473800.0 False True 9781455.6892567 2879503.5216676444 7827441.648530773 1.0 0.29438394582007865 0.8002327973665427 23.221617754276014 -9.926512916878952 6.3984089874856735 1.0000000612622661 0.5473083715940664 0.5164012561963809 0.2065119288770395 1.805468553031819e-07 3.026860238803034e-08 0.19995434214924568 0.06665143844448254 1.1843691407141523e-10 9.926512916878952 -0.4526916896681997 TSGVVTSCTGVLPQLSMVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSGVVTSCTGVLPQLSMVK 19 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 25247100.0 6988000.0 10788000.0 7471100.0 False True 9046103.75407338 10187638.316585839 6111436.459959565 1.0 1.1261907439430414 0.675587703402986 23.108865112345093 -6.831941178994332 1.3191207401649976 1.0673440255047728 0.6629664424249863 0.9097163706603859 0.057029138892750665 0.17842932770893488 0.6065168580968661 0.03393666384872709 0.07810024611884565 1.4725119264887206e-07 6.831941178994332 -0.40437758307978655 TSIAIDTIINQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSIAIDTIINQK 12 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 117421000.0 30917000.0 49484000.0 37020000.0 False True 40532486.40065392 42101180.087121196 33189525.52091516 1.0 1.0387021331719233 0.8188376403274314 25.272575342134356 -6.861454121513838 1.1784542528431443 1.0210825721274752 0.8078956800755512 0.9553782622152897 0.02024391701750358 0.14530663499362748 0.38263970868865976 0.013390791369855748 0.0313091784423934 1.3757701377434088e-07 6.861454121513838 -0.21318689205192398 TSIAIDTIINQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSIAIDTIINQK 12 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 193804000.0 55073000.0 41816000.0 96915000.0 False True 53324737.76043609 58513346.8675592 71530054.11232111 1.0 1.09730210264574 1.3414047047671058 25.66830162993165 -6.955387158554408 0.4961928676131641 0.9949458612962736 1.4542213573277214 0.9995590245159168 0.003015691914935958 0.08139197697894475 0.027547899638602914 0.003562473401153712 0.020134151689679768 1.1081864647690196e-07 6.955387158554408 0.4592754960314478 TSIAIDTIINQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSIAIDTIINQK 12 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 492706000.0 86876000.0 255770000.0 150060000.0 False True 131797243.48634766 210125845.1598691 120400575.2263655 1.0 1.5943113801286382 0.9135287813423603 26.973744956074885 -6.676038694981552 1.9164279151401225 1.377363749895857 0.9162215086131248 0.3059333766269565 0.2521053092448876 0.44735539362396504 3.1731571337969253 0.10570342138600733 0.28016077045366383 2.1084402827234873e-07 6.676038694981552 -0.4611422412827323 TSIAIDTIINQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSIAIDTIINQK 12 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 191399000.0 30917000.0 43002000.0 117480000.0 False True 42347850.40050954 41102029.45140222 89733643.5765482 1.0 0.9705812470450133 2.11896572619111 25.335785403657248 -6.901021070469044 0.9547866406826817 0.953582833898962 2.2420406911331052 0.9870675945120015 0.060789930769144046 0.11065770871984987 0.17320974184619134 0.04765839632574812 0.1246469448632189 1.255969026935181e-07 6.901021070469044 1.2884578572341432 up TSIAIDTIINQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSIAIDTIINQK 12 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 135530000.0 55073000.0 35917000.0 44540000.0 False True 45795639.64757579 35723507.9920337 53853108.07030812 1.0 0.780063522792715 1.1759440087471047 25.448706905365928 -6.7559197663836565 1.6279180310741295 0.8716020129078528 1.177101398489296 0.6740575625837888 0.09245937051997474 0.28982609741476395 1.5128173261663722 0.044834533193642674 0.10817919847645939 1.754204551952037e-07 6.7559197663836565 0.3054993855814432 TSIAIDTIINQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSIAIDTIINQK 12 0 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 359526000.0 86876000.0 153330000.0 119320000.0 False True 112462694.5819803 144797050.7120977 97604984.32658865 1.0 1.287511838928482 0.8678876554521726 26.744871278167334 -6.722304688453913 1.7512082984564106 1.1744884695134836 0.8684637326293748 0.5232942576827283 0.1209530168251247 0.3508553218981236 2.1040611969213665 0.05481741047604786 0.13723093149492524 1.895375713838904e-07 6.722304688453913 -0.3060247368841088 TSIAIDTIINQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSIAIDTIINQKR 13 1 P25705;P25705-2;P25705-3;K7EK77;K7ENJ4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 1 7546700.0 2023100.0 2497100.0 3026500.0 True False 1682297.288526331 2483647.6266644583 3659327.1570450673 1.0 1.4763428816081008 2.1751964899441685 20.68200124446777 -6.965622896079057 0.3471955315868283 0.9302473170088248 2.744772750429948 0.9999254160119256 0.004168086502433381 0.07775021435331493 0.014118166590062401 0.009663461153524452 0.06018181576613498 1.0823733831958041e-07 6.965622896079057 1.8145254334211234 TSIFWNDVK(ub)DPVSIEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSIFWNDVKDPVSIEER 17 1 P55884;P55884-2;C9JZG1;C9JQN7 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 15898000.0 4705400.0 6274000.0 4918600.0 True False 6168824.967158421 5337943.655860451 4409670.454542764 1.0 0.8653096309716333 0.7148315081103711 22.556564281471204 -6.969691514711143 0.26545321378078046 1.0395309257519116 0.5361136712124542 0.9999798724072742 0.0005225370234028512 0.07640295658937446 0.009387844180221191 0.0030340453077964333 0.014084874987997828 1.0722806903813869e-07 6.969691514711143 -0.5034172545394574 TSIFWNDVK(ub)DPVSIEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSIFWNDVKDPVSIEER 17 1 P55884;P55884-2;C9JZG1;C9JQN7 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 33128400.0 11741000.0 8616400.0 12771000.0 True False 11368288.381698474 12056973.453932399 9425891.978212394 1.0 1.0605794864724423 0.8291390631316939 23.43851172150948 -6.837168579337165 1.295573401637272 1.0322472751170626 0.821948042634476 0.9194587369921439 0.02781090969802561 0.17213332985145027 0.5624791590851774 0.016840125060738217 0.038769946548023126 1.4548942271866048e-07 6.837168579337165 -0.21029923248258664 TSIFWNDVK(ub)DPVSIEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSIFWNDVKDPVSIEER 17 1 P55884;P55884-2;C9JZG1;C9JQN7 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 98581000.0 16802000.0 29317000.0 52462000.0 True False 25489862.3907364 24085152.295233525 42092862.70508857 1.0 0.9448914209904334 1.651357000671219 24.60342024907663 -6.888053545076228 1.0338540152582685 0.9602504643036646 1.7098463361973584 0.9796219712313403 0.04579924126105405 0.12073558031615758 0.23119944212566634 0.03383776628674398 0.08378612239804596 1.294036287170319e-07 6.888053545076228 0.7495958718936938 TSIFWNDVK(ub)DPVSIEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSIFWNDVKDPVSIEER 17 1 P55884;P55884-2;C9JZG1;C9JQN7 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 18617500.0 4705400.0 7338600.0 6573500.0 True False 6445113.538653735 7014356.3864950575 5020974.685482118 1.0 1.0883216167453624 0.7790358781687043 22.619774342994095 -6.830373190811846 1.3261445914714425 1.047182956699831 0.7706443050533217 0.906628545404454 0.039747723103762574 0.18035796005883764 0.6201912413763064 0.023531465603690373 0.05415473316739399 1.4778379309375814e-07 6.830373190811846 -0.27653865164650926 TSIFWNDVK(ub)DPVSIEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSIFWNDVKDPVSIEER 17 1 P55884;P55884-2;C9JZG1;C9JQN7 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 34678500.0 11741000.0 14101000.0 8836500.0 True False 9763161.714491442 14025035.114170633 10684171.29464027 1.0 1.4365259456220316 1.09433517615321 23.218916996943758 -9.868402253652285 5.257569356309119 0.9999997018071146 1.2654305608922771 0.4451347681481065 0.13969879666443896 4.883510430484811e-07 1.0504247302160812e-07 0.13526292940087567 0.04508759280386157 1.353934785513043e-10 9.868402253652285 0.2654308590851625 TSIFWNDVK(ub)DPVSIEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSIFWNDVKDPVSIEER 17 1 P55884;P55884-2;C9JZG1;C9JQN7 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 97397000.0 16802000.0 29844000.0 50751000.0 True False 21750520.216934882 28183155.16501558 41514838.74923483 1.0 1.2957462572813438 1.9086825664478368 24.37454657116908 -6.959342838114943 0.4446057297413271 0.9791071957907143 2.2494024989157366 0.9997450239620982 0.0060427027960179526 0.07993681738094405 0.02200572185141308 0.008129783365671198 0.05074350066474038 1.098138611256707e-07 6.959342838114943 1.2702953031250224 TSIGHVVQLLYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSIGHVVQLLYR 12 0 A6NHN2;Q9HBD1-2;Q9HBD1-3;Q9HBD1-6;Q9HBD1-4;Q5TC82-2;Q5TC82;Q9HBD1 A6NHN2 RC3H2;RC3H1 Roquin-2;Roquin-1 0 8200300.0 4057600.0 1924700.0 2218000.0 False True 5319552.893854292 1637542.26242184 1988502.636558343 1.0 0.307834567133208 0.37381010702152634 22.342873562245003 -10.141307088758671 5.248236301663106 1.0000205295378821 0.34082233709641147 0.9925428736794313 0.026934401373391814 6.470141723451564e-06 1.0586968926013045e-06 0.026079932544234893 0.008693040663043558 7.22258915166452e-11 10.141307088758671 -0.6591981924414707 TSIGHVVQLLYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSIGHVVQLLYR 12 0 A6NHN2;Q9HBD1-2;Q9HBD1-3;Q9HBD1-6;Q9HBD1-4;Q5TC82-2;Q5TC82;Q9HBD1 A6NHN2 RC3H2;RC3H1 Roquin-2;Roquin-1 0 11486100.0 5338500.0 2247200.0 3900400.0 False True 5169032.239647164 3144518.6789931906 2878768.230508149 1.0 0.6083379892418381 0.5569259577116997 22.301462769834934 -13.999999999999998 0.2862152183604008 4.3040164058391115 0.5423739769834593 0.9996190001296775 0.003862176221693683 15.744648340672414 0.16957958049219535 30.56208856279295 0.01975494432105874 1.0000000000000041e-14 13.999999999999998 -3.761642428855652 TSIGHVVQLLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSIGHVVQLLYR 12 0 A6NHN2;Q9HBD1-2;Q9HBD1-3;Q9HBD1-6;Q9HBD1-4;Q5TC82-2;Q5TC82;Q9HBD1 A6NHN2 RC3H2;RC3H1 Roquin-2;Roquin-1 0 11172600.0 4057600.0 2681000.0 4434000.0 False True 5557804.372516974 2562544.5551185817 3386780.5210964833 1.0 0.4610713841944885 0.6093738271616612 22.406083623767895 -10.526826827041155 9.512417718758869 1.0000146630434783 0.5352226056781283 0.9290568946549264 0.0605442188129628 1.882793133496221e-05 9.365476594248199e-07 0.05862353103112131 0.01954056259764522 2.972851206392881e-11 10.526826827041155 -0.46479205736535 TSIGHVVQLLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSIGHVVQLLYR 12 0 A6NHN2;Q9HBD1-2;Q9HBD1-3;Q9HBD1-6;Q9HBD1-4;Q5TC82-2;Q5TC82;Q9HBD1 A6NHN2 RC3H2;RC3H1 Roquin-2;Roquin-1 0 6977700.0 5338500.0 1639200.0 0.0 False True 4439199.285649656 1630369.304244275 0.0 1.0 0.36726652698712486 0.0 22.08186804526921 -8.41917492196333 0.520922604808178 1.043490533561022 1.8975317691952557e-19 0.9929038506042189 0.03479186718113573 0.1894702886718776 0.18127269815558322 0.0706032561073254 0.06854898383914512 3.8091237138643926e-09 8.41917492196333 -1.043490533561022 TSIGHVVQLLYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSIGHVVQLLYR 12 0 A6NHN2;Q9HBD1-2;Q9HBD1-3;Q9HBD1-6;Q9HBD1-4;Q5TC82-2;Q5TC82;Q9HBD1 A6NHN2 RC3H2;RC3H1 Roquin-2;Roquin-1 0 9926500.0 1332500.0 4298000.0 4296000.0 False True 1724947.5175018301 4058812.5217543514 3514172.080682407 1.0 2.35300638458413 2.0372631891849307 20.718121037074873 -10.15888816965774 5.059772845425385 0.9999336895408752 2.195134786886205 0.9502565001868006 0.1289016197531401 9.642645779241445e-05 1.6029769980052352e-05 0.12481530636215356 0.04160281888275523 6.936043853753168e-11 10.15888816965774 1.1952010973453298 TSIHEAMEQQSISISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSIHEAMEQQSISISK 16 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 25600600.0 5197800.0 13317000.0 7085800.0 False True 6814366.135566801 11330155.50925942 6352629.387793105 1.0 1.6626866364169919 0.932240689950058 22.70014803477657 -6.667854549635251 1.945121511584791 1.4237676899783553 0.9352271205142881 0.2695536841208207 0.2816345930924015 0.4660389805775917 3.3973463914000592 0.11665431801949802 0.312529380532523 2.14854992846032e-07 6.667854549635251 -0.4885405694640672 TSIHEAMEQQSISISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSIHEAMEQQSISISK 16 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 16850300.0 4136600.0 3829800.0 8883900.0 False True 4005285.8972603576 5359059.112143161 6556940.078712793 1.0 1.337996649829365 1.6370716715123341 21.933473795188767 -6.97256746097835 0.18695153281939275 0.7890490934238373 2.1941638019068956 0.999996099102038 0.0005139697607127513 0.075478077650326 0.005942884774315633 0.010838383817834326 0.03288293868227422 1.0652033878277449e-07 6.97256746097835 1.4051147084830582 TSIHEAMEQQSISISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSIHEAMEQQSISISK 16 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 22554200.0 5197800.0 11884000.0 5472400.0 False True 7119567.125263393 11358925.584867304 4179931.8276157803 1.0 1.5954517156753507 0.5871047711290651 22.763358096299463 -6.7466929714119805 1.6619851035149484 1.3515225683183334 0.5855855372519996 0.6346321078778311 0.2501838040903665 0.3058624510085413 1.6611617124368738 0.11896556711498776 0.2898373597564357 1.7918721873352495e-07 6.7466929714119805 -0.7659370310663338 TSIHEAMEQQSISISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSIHEAMEQQSISISK 16 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 10523000.0 4136600.0 4319200.0 2067200.0 False True 3439766.1824516873 4295931.61230593 2499441.962347127 1.0 1.2489022173140885 0.726631355089855 21.713879070623044 -6.777105348579724 1.5469596603471079 1.1414694993591992 0.7228521263502916 0.7570262849166405 0.10513773303755214 0.25512689586885007 1.2056886849111332 0.05353869596904084 0.12664788446155273 1.6706853002216562e-07 6.777105348579724 -0.41861737300890756 TSIHEAMEQQSISISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSIHEAMEQQSISISK 16 0 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 0 18267100.0 5798200.0 6864100.0 5604800.0 False True 7505884.199609086 6482106.800971159 4584783.9101044545 1.0 0.8636033581904652 0.6108252922877807 22.839590601896727 -6.961507608475307 0.41364231395405954 1.0119682101602472 0.45302377348530426 0.9998220813421239 0.0021505851531844365 0.07916695959454972 0.019173750789769278 0.0032590278365591456 0.021080864490131357 1.0926784842100417e-07 6.961507608475307 -0.558944436674943 TSIHEAMEQQSISISK(ub)AGIVTSLQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSIHEAMEQQSISISKAGIVTSLQAR 26 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 59758000.0 12423000.0 19982000.0 27353000.0 True False 18846599.242954288 16416055.979921404 21946667.5607542 1.0 0.871035446145992 1.164489533514056 24.167800885426917 -6.787262083117822 1.5074171178038227 0.9276647412194982 1.1673727184057248 0.7922890583015457 0.05473339768390553 0.23945314260451503 1.0749668389820628 0.02858546868534662 0.0670568367008327 1.6320667494886933e-07 6.787262083117822 0.2397079771862266 TSIHEAMEQQSISISK(ub)AGIVTSLQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSIHEAMEQQSISISKAGIVTSLQAR 26 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 60550000.0 12423000.0 25176000.0 22951000.0 True False 16081818.39394011 23774933.46851734 18774153.49714661 1.0 1.47837345790922 1.167414843101388 23.938927207519367 -10.250445018423383 5.05420199868058 0.9999474473419163 1.3228941505048768 0.5897692447239571 0.1269483229008654 89683278.18198787 4.956379596938077 54857.78359399454 0.043457787556324894 5.6176539321721416e-11 10.250445018423383 0.3229467031629605 TSILAAANPISGHYDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSILAAANPISGHYDR 16 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 61828500.0 18225000.0 21510300.0 22093200.0 False True 23893151.491151053 18301047.08649271 19807207.59693904 1.0 0.7659536705850877 0.8289910020565824 24.51009382109462 -10.044968083078796 5.429923870793924 1.0000013204858438 0.7974723363206498 0.9322628968062395 0.02573488280929231 4.1139660694604164e-07 7.234783510837528e-08 0.024917855758388875 0.008305897711321515 9.016373977901298e-11 10.044968083078796 -0.20252898416519394 TSILAAANPISGHYDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSILAAANPISGHYDR 16 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 49147500.0 17172000.0 8968900.0 23006600.0 False True 16626884.259477561 12550228.542195618 16980481.2767944 1.0 0.7548154149832257 1.0212665831913326 23.987014509051814 -11.804922026208075 12.76945614087291 0.912967855112344 0.899236899385996 0.0 0.12369587884799314 0.0 0.0 0.0 0.03601858248904068 1.5670323918715233e-12 11.804922026208075 -0.013730955726347971 TSILAAANPISGHYDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSILAAANPISGHYDR 16 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 65834500.0 18225000.0 24990000.0 22619500.0 False True 24963275.01210615 23885859.16912102 17277239.96322551 1.0 0.9568399642089177 0.6921063023520259 24.573303882617513 -6.935369748294707 0.701313138394146 1.003338455322409 0.6294937107764351 0.9974923793214874 0.006816104183736906 0.08994386730121551 0.06471264971690646 0.006421781927934192 0.023287388511499058 1.1604602041208759e-07 6.935369748294707 -0.37384474454597383 TSILAAANPISGHYDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSILAAANPISGHYDR 16 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 35894000.0 17172000.0 11528100.0 7193900.0 False True 14279278.848585889 11465995.83715131 8698111.229164565 1.0 0.8029814361589286 0.6091421927813925 23.76741978448609 -6.971326047455185 0.2242830999618234 1.0846934992912656 0.32192925029635366 0.9999909548257834 0.000479871539168434 0.0758748730579096 0.007472576300290416 0.005197370122454779 0.019472397660230293 1.0682525853229311e-07 6.971326047455185 -0.7627642489949119 TSILAAANPISGHYDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSILAAANPISGHYDR 16 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 51666800.0 20291800.0 15608000.0 15767000.0 False True 26268135.111177176 14739401.079465311 12897567.783081803 1.0 0.5611133419666952 0.49099670488575514 24.64681044514147 -13.999999999999998 0.25813775954198337 4.181908246719012 0.4649087167120333 0.9995585570267711 0.004732539368891466 14.335593443834556 0.1607742106943529 23.76799842031979 0.030957730407604574 1.0000000000000041e-14 13.999999999999998 -3.716999530006979 TSK(ub)AEELLAEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSKAEELLAEEK 12 1 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 1 3992300.0 2645800.0 1346500.0 0.0 True False 2561810.5272376994 1884164.4719047362 0.0 1.0 0.7354815868979809 0.0 21.28873234651704 -7.360528576215594 0.7822179086628263 0.9896153370921755 9.484835296887651e-24 0.9877373680947135 0.04684953709611364 0.10984679925825847 0.13808891952279426 0.04030120211564227 0.07184568943863644 4.3598487561447965e-08 7.360528576215594 -0.9896153370921755 down TSK(ub)AEELLAEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSKAEELLAEEK 12 1 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 1 21486600.0 3547900.0 7019700.0 10919000.0 True False 5382423.6862334 5766979.689833565 8760854.86403228 1.0 1.0714466244238152 1.6276784167771625 22.359824528858695 -6.930605173360522 0.7418027818088605 0.9917288925945777 1.743651952354623 0.9966559996744413 0.01622464669409727 0.09232445405106587 0.07614805372180414 0.014835097042141629 0.050162775367031474 1.1732615186244689e-07 6.930605173360522 0.7519230597600453 TSK(ub)AEELLAEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSKAEELLAEEK 12 1 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 1 6461800.0 1939700.0 2211400.0 2310700.0 True False 2656859.5084215277 2113693.035878117 1764960.2503603152 1.0 0.7955607096191126 0.6643031913301654 21.34129051116751 -9.537700505515394 0.06580266819428747 1.80116262001053 1.8584544733769818e-11 0.9999891116000752 0.0004557552738173983 1.0224510225379526 0.02642779293043637 0.42817502550065295 0.2924230301332142 2.8993423183569005e-10 9.537700505515394 -1.8011626199919455 TSK(ub)AEELLAEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSKAEELLAEEK 12 1 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 1 6867700.0 2645800.0 2434900.0 1787000.0 True False 2200099.928813684 2421782.7104101917 2160653.437845545 1.0 1.1007603239713033 0.9820705912256409 21.069137621951317 -6.681783476767965 1.8954951827582422 1.0636509751549188 0.9825157598439174 0.33225975716293565 0.04268828604223274 0.4346146790583147 3.0205651459518883 0.018060577428150596 0.04752597807761867 2.0807338057822126e-07 6.681783476767965 -0.08113521531100143 TSK(ub)AEELLAEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSKAEELLAEEK 12 1 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;O00429-7 O00429-9 DNM1L Dynamin-1-like protein 1 16068500.0 3547900.0 5654200.0 6866400.0 True False 4592826.489564528 5339538.799558743 5616785.655213605 1.0 1.1625823034444775 1.2229474960518625 22.130950850951145 -13.999999999999998 0.1376119035972143 0.22485304714467924 1.2998464135425962 0.9996126209156784 0.0018530992194466837 11.93251121601391 0.11604676738803954 2.4872805031569336 0.06864345355534696 1.0000000000000041e-14 13.999999999999998 1.074993366397917 TSK(ub)EGVDESFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSKEGVDESFIK 12 1 Q9H583;Q5T3Q7 Q9H583 HEATR1 HEAT repeat-containing protein 1;HEAT repeat-containing protein 1, N-terminally processed 1 28805600.0 11015800.0 13205000.0 4584800.0 True False 14441820.47715896 11234865.472686838 4110408.876507073 1.0 0.7779396988389234 0.2846184719584387 23.78374927816973 -6.95793963564697 0.4635650845940616 1.0138787769750228 0.028673531190774572 0.9996859655278745 0.005298048866729551 0.08044559016812697 0.023914740098529935 0.00674138943043111 0.040738371500297174 1.1016924276026787e-07 6.95793963564697 -0.9852052457842483 down TSK(ub)EGVDESFIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSKEGVDESFIK 12 1 Q9H583;Q5T3Q7 Q9H583 HEATR1 HEAT repeat-containing protein 1;HEAT repeat-containing protein 1, N-terminally processed 1 14431300.0 6192600.0 4805000.0 3433700.0 True False 5996019.302657866 6723661.55774398 2534310.96120804 1.0 1.1213542215855727 0.4226655774914953 22.51557359700687 -6.8620976855667015 1.1750038097426136 1.0662510580843056 0.38743659438224615 0.9561448155802418 0.06383315298558802 0.14466142761125456 0.37831649150514474 0.04233215508875148 0.09906688652970197 1.3737329474280997e-07 6.8620976855667015 -0.6788144637020594 down TSK(ub)EGVDESFIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSKEGVDESFIK 12 1 Q9H583;Q5T3Q7 Q9H583 HEATR1 HEAT repeat-containing protein 1;HEAT repeat-containing protein 1, N-terminally processed 1 42961900.0 17181600.0 10401200.0 15379100.0 True False 26065743.343213666 8545024.595053473 12339414.144101018 1.0 0.3278258548984834 0.47339582768176225 24.6356516675284 -10.055421458783092 7.483644577504009 1.000000051146845 0.40061084129408636 0.9576368774597906 0.05942869253164473 5.073628815244728e-08 6.301610250283335e-09 0.05754158926005859 0.019180528038495084 8.801942785242593e-11 10.055421458783092 -0.5993892098527587 TSK(ub)EGVDESFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSKEGVDESFIK 12 1 Q9H583;Q5T3Q7 Q9H583 HEATR1 HEAT repeat-containing protein 1;HEAT repeat-containing protein 1, N-terminally processed 1 24892500.0 11015800.0 9080100.0 4796600.0 True False 15088638.9508016 8678911.158124667 3663741.869077893 1.0 0.57519509787618 0.2428146024982096 23.84695933969262 -7.914871292913562 0.2825020971287971 1.13347496461386 2.5455521543754092e-23 0.9994352501645978 0.0073642803523711105 0.10895185471993726 0.04926887031382269 0.053683880235200855 0.08882317527123677 1.2165464817492239e-08 7.914871292913562 -1.13347496461386 down TSK(ub)EGVDESFIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSKEGVDESFIK 12 1 Q9H583;Q5T3Q7 Q9H583 HEATR1 HEAT repeat-containing protein 1;HEAT repeat-containing protein 1, N-terminally processed 1 21421700.0 6192600.0 11650100.0 3579000.0 True False 5149421.278695148 11587338.598936219 4327352.352573705 1.0 2.2502215242860113 0.8403570262307701 22.295978872441147 -6.6727247484364565 1.9279125074563979 1.7961379221956344 0.8460056250396387 0.2911231056149237 0.5307360099699213 0.45486862801806666 3.262073766579645 0.2214310759653684 0.589471698974445 2.124590579953077e-07 6.6727247484364565 -0.9501322971559957 TSK(ub)EGVDESFIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSKEGVDESFIK 12 1 Q9H583;Q5T3Q7 Q9H583 HEATR1 HEAT repeat-containing protein 1;HEAT repeat-containing protein 1, N-terminally processed 1 38473400.0 17181600.0 10533300.0 10758500.0 True False 22241919.899969522 9947112.595485136 8800563.391532049 1.0 0.4472236497667976 0.3956746284093986 24.40677798962085 -13.999999999999998 0.3356300564066748 7.225701069349269 0.38713626125455564 0.9997264053542275 0.004524575316598748 19.310090538202537 0.18557362811810546 85.10695475948873 0.01617970755682508 1.0000000000000041e-14 13.999999999999998 -6.838564808094714 TSK(ub)EVYDHAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSKEVYDHAR 10 1 Q8WY64;Q5TIA5 Q8WY64 MYLIP E3 ubiquitin-protein ligase MYLIP 1 7025770.0 931470.0 1157100.0 4937200.0 True False 1221166.1903683112 984465.1903404727 4426345.9049665695 1.0 0.806168069592192 3.6246875649509724 20.219828121577972 -6.890422015998135 1.019900510771518 0.8500858622959017 3.869104284124049 0.9811664023407074 0.1764045361972633 0.11880070048517102 0.21986163206216455 0.13171692572240318 0.32886974878999287 1.2869983318805408e-07 6.890422015998135 3.019018421828147 up TSK(ub)EVYDHAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSKEVYDHAR 10 1 Q8WY64;Q5TIA5 Q8WY64 MYLIP E3 ubiquitin-protein ligase MYLIP 1 10199500.0 1358800.0 1983200.0 6857500.0 True False 1315665.6377695173 2775102.102251374 5061315.029409715 1.0 2.109276112854994 3.8469614802665943 20.32736145959583 -6.964526202239509 0.36609226444313725 0.8603082493840117 5.1560461734251914 0.9999030437984064 0.011536975435350413 0.07812210082884556 0.015429054531491354 0.023049287717924055 0.14789733139683772 1.0851100798349609e-07 6.964526202239509 4.2957379240411795 TSK(ub)EVYDHAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSKEVYDHAR 10 1 Q8WY64;Q5TIA5 Q8WY64 MYLIP E3 ubiquitin-protein ligase MYLIP 1 8570270.0 931470.0 1005300.0 6633500.0 True False 1275859.6310302613 960882.5219174604 5066803.921220909 1.0 0.7531255778831596 3.971286337455043 20.283038183100864 -6.888387183760197 1.0319020726704133 0.820338953644046 4.239461367587829 0.9798448066335915 0.2076074880331538 0.1204604212131905 0.22958250639251754 0.15361356812354576 0.38079458369676394 1.2930425495430623e-07 6.888387183760197 3.419122413943783 up TSK(ub)EVYDHAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSKEVYDHAR 10 1 Q8WY64;Q5TIA5 Q8WY64 MYLIP E3 ubiquitin-protein ligase MYLIP 1 7891300.0 1358800.0 2121600.0 4410900.0 True False 1129902.4050465024 2110170.5196953705 5333198.796302694 1.0 1.86756883627354 4.720052610281151 20.107766735030108 -6.949374332143703 0.5656702338106363 0.9637421907506716 5.761537720225089 0.9991512691522669 0.04629622664364972 0.0837379446656101 0.03700956937531008 0.04929377862459828 0.23742184042918224 1.1236360590158926e-07 6.949374332143703 4.797795529474417 TSK(ub)THTDTESEASILGDSGEYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSKTHTDTESEASILGDSGEYK 22 1 J3KQ48;Q9Y3E5 J3KQ48 PTRH2 Peptidyl-tRNA hydrolase 2, mitochondrial 1 14510100.0 5857300.0 3262500.0 5390300.0 True False 7678977.022173891 2775747.717125397 4832563.463408664 1.0 0.3614736323744843 0.6293238603858438 22.87248270014862 -10.378773589205311 5.926269570238591 1.0001050492970487 0.4953987463802219 0.8255430151146832 0.10934939768599505 0.00015180367590950512 1.5912705549285994e-05 0.1058989219218814 0.035292366346305656 4.1804825099201736e-11 10.378773589205311 -0.5047063029168268 TSK(ub)THTDTESEASILGDSGEYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSKTHTDTESEASILGDSGEYK 22 1 J3KQ48;Q9Y3E5 J3KQ48 PTRH2 Peptidyl-tRNA hydrolase 2, mitochondrial 1 16504800.0 7949000.0 5809200.0 2746600.0 True False 6609945.700408186 5777904.686564085 3320901.3611564483 1.0 0.8741228670316128 0.5024097793952182 22.65620698960879 -6.951805478547439 0.5386606168814089 1.005521310911656 0.35388503750248973 0.9993354430385075 0.0054456256766908595 0.08276881025849228 0.03302424375922199 0.0060006480071861275 0.03077660330383717 1.1173636053301746e-07 6.951805478547439 -0.6516362734091663 TSK(ub)VRPSTGNSASTPQSQCLPSEIEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSKVRPSTGNSASTPQSQCLPSEIEVK 27 2 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 1 23895800.0 6371500.0 5180300.0 12344000.0 True False 8248032.3510415815 4892011.751150318 10097518.66013585 1.0 0.593112580424414 1.224233639052193 22.97561856068632 -6.732625111340583 1.7135493520711182 0.7558557399105665 1.2240489698949297 0.5714237713358439 0.17101361209661245 0.3313475242583095 1.907180126377505 0.0790483329821427 0.1955809830681829 1.850865620939344e-07 6.732625111340583 0.4681932299843632 TSLCK(ub)ALAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSLCKALAQK 10 1 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 5677000.0 1102900.0 1960100.0 2614000.0 True False 1445912.5804987927 1667660.7204099596 2343528.35525857 1.0 1.1533620655231251 1.620795328062039 20.463548899280305 -6.951093888061354 0.546702187915039 0.9934055384820343 1.802587362801487 0.9992843574896496 0.007063161497481216 0.08304943053935283 0.034167280203510876 0.007699088459832676 0.03875403305685627 1.1191959036650865e-07 6.951093888061354 0.8091818243194527 TSLCK(ub)ALAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSLCKALAQK 10 1 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 5102000.0 1102900.0 1362000.0 2637100.0 True False 1510671.9347518173 1301822.336468298 2014271.292779323 1.0 0.8617505273785135 1.3333611662748208 20.526758960803196 -6.828240572557085 1.335904642113507 0.9260356170876176 1.3455883277500675 0.9022795562467523 0.06187982183577897 0.18299411517188424 0.6393445306547766 0.036376916612711356 0.08371516050968736 1.4851127528408513e-07 6.828240572557085 0.4195527106624499 TSLDLYANVIHCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSLDLYANVIHCK 13 0 E9PF84;E7EQB8;P51553-2;P51553;H7C1W2;G5E9Q7 E9PF84 IDH3G Isocitrate dehydrogenase [NAD] subunit, mitochondrial;Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial 0 11863500.0 3871000.0 7992500.0 0.0 False True 5872590.008007407 6566175.9293124825 0.0 1.0 1.1181056263691753 0.0 22.485565489628193 -6.951026538514669 1.2021121779411448 1.0668032507239635 3.33856442305596e-19 0.9722029739810818 0.08362316274283665 0.10722952084815392 0.3079035166740613 0.057853169466338554 0.10985398415566877 1.1193694798556506e-07 6.951026538514669 -1.0668032507239635 down TSLGNVVLLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSLGNVVLLLK 11 0 O60231;Q5SQH5;A0A140T8Y5 O60231 DHX16 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 0 16076700.0 3426900.0 8386600.0 4263200.0 False True 4492699.086146809 7135351.970710757 3822084.9595020367 1.0 1.588210524206382 0.8507324630949346 22.099151004997683 -6.694242222088405 1.8512005945573975 1.3672925809518905 0.8531340350876285 0.3903990311032154 0.24856147766557785 0.4076231028084171 2.711484157033865 0.10728159725826088 0.2778986429021321 2.0218911806837286e-07 6.694242222088405 -0.514158545864262 TSLGNVVLLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSLGNVVLLLK 11 0 O60231;Q5SQH5;A0A140T8Y5 O60231 DHX16 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 0 11677700.0 3761400.0 3875100.0 4041200.0 False True 3641996.4158862606 5422447.638379543 2982688.4865986947 1.0 1.488866824450188 0.8189707363764314 21.796298071873505 -6.7110351652801 1.791304106143889 1.300225632861148 0.8204828288715488 0.4700738260103223 0.2059730478974415 0.37301967940800895 2.3338089792504473 0.09147762458988948 0.23212324069265777 1.9452025701517357e-07 6.7110351652801 -0.4797428039895991 TSLGNVVLLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSLGNVVLLLK 11 0 O60231;Q5SQH5;A0A140T8Y5 O60231 DHX16 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 0 16752200.0 3426900.0 4980600.0 8344700.0 False True 4693917.5384903485 4760540.6233583065 6373853.7244911585 1.0 1.0141934928173846 1.3578963993775461 22.162361066520575 -6.915586095731803 0.8568299809385097 0.9911444499525257 1.4080595325481153 0.9928642270586452 0.013977832075278994 0.10083896648725456 0.11958916183146658 0.011769839135904953 0.03389633381748543 1.2145458217016867e-07 6.915586095731803 0.4169150825955896 TSLGPNGLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSLGPNGLDK 10 0 P48643;B7ZAR1;E9PCA1 P48643 CCT5 T-complex protein 1 subunit epsilon 0 15668700.0 2127000.0 8601600.0 4940100.0 False True 2788517.5978973005 7318274.8087741835 4428945.840785333 1.0 2.624431997234866 1.5882796809763753 21.41106694495363 -10.496676020449287 5.0346548774540265 0.9967653127022664 2.106355839105656 0.6031953305525921 0.42300741177282286 0.015381669243011964 0.0015377316681097434 0.4101902853276702 0.13652505509318638 3.186573789002396e-11 10.496676020449287 1.1095905264033894 TSLGPNGLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSLGPNGLDK 10 0 P48643;B7ZAR1;E9PCA1 P48643 CCT5 T-complex protein 1 subunit epsilon 0 17480000.0 4663500.0 3019200.0 9797300.0 False True 4515459.745170836 4224782.304920002 7231093.217300155 1.0 0.9356261695031816 1.6014079684872877 22.10644145366621 -6.88316449902235 1.061948320873224 0.9581486402408563 1.6515597260866883 0.9761514566090075 0.04630320188830399 0.1248658597473472 0.25563673566957146 0.03348518510665775 0.08167089048308156 1.3086861341408818e-07 6.88316449902235 0.693411085845832 TSLGPNGLDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSLGPNGLDK 10 0 P48643;B7ZAR1;E9PCA1 P48643 CCT5 T-complex protein 1 subunit epsilon 0 51932300.0 8203900.0 38985000.0 4743400.0 False True 12445916.085428046 32027822.158804707 3805864.910893921 1.0 2.5733599631371122 0.3057922683047744 23.569169088444774 -6.720070501433015 1.75896018431524 1.9571264731284568 0.3092833872193673 0.5129164646735056 0.6620683862951457 0.3551696191606581 2.1475779304137546 0.29885442347859553 0.7502029192130685 1.9051514190578632e-07 6.720070501433015 -1.6478430859090896 TSLGPNGLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSLGPNGLDK 10 0 P48643;B7ZAR1;E9PCA1 P48643 CCT5 T-complex protein 1 subunit epsilon 0 13156800.0 2127000.0 5552500.0 5477300.0 False True 2913409.3800137057 5307172.190337907 4183674.5485344455 1.0 1.821636268059568 1.4360064113319921 21.474277006476523 -10.056044265969032 5.062345739583932 0.9999895312525804 1.6288213396986648 0.7799921191717094 0.15743272977088152 1.8601883935468092e-05 3.4685097417061023e-06 0.1524361200245966 0.050811195044446054 8.789329260067236e-11 10.056044265969032 0.6288318084460844 TSLGPNGLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSLGPNGLDK 10 0 P48643;B7ZAR1;E9PCA1 P48643 CCT5 T-complex protein 1 subunit epsilon 0 9049700.0 4663500.0 2904800.0 1481400.0 False True 3877906.878079449 2889151.265842345 1791153.8907802952 1.0 0.7450285312867571 0.4618867721927795 21.886846729100487 -6.96977302367577 0.2635562412158416 1.0761190074699516 0.12235672221769146 0.9999805554280171 0.0009691428731391439 0.07637645428581928 0.00929360373853026 0.00577764149055956 0.02657491461577565 1.0720794622025889e-07 6.96977302367577 -0.9537622852522601 down TSLGPNGLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSLGPNGLDK 10 0 P48643;B7ZAR1;E9PCA1 P48643 CCT5 T-complex protein 1 subunit epsilon 0 21629000.0 8203900.0 6862400.0 6562700.0 False True 10620110.273045579 6480501.407465587 5368355.938988454 1.0 0.6102103688992245 0.5054896607442613 23.340295410537223 -13.999999999999998 0.18446449738381385 3.0511149733534215 0.4260292616328926 0.9994934275924823 0.004788864515044524 12.265751002951612 0.13618379317295312 9.027412151145992 0.07531955108709669 1.0000000000000041e-14 13.999999999999998 -2.625085711720529 TSLSAPPNSSSTENPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSLSAPPNSSSTENPK 16 0 Q16666;Q16666-2;Q16666-3;H3BR88;H3BR65 Q16666 IFI16 Gamma-interferon-inducible protein 16 0 6783290.0 693690.0 4630400.0 1459200.0 False True 1052378.4455320763 3804068.9425196755 1170788.48040992 1.0 3.614734755039914 1.1125165907574022 20.00522217443963 -6.635855166563319 2.059101544001708 2.7152036360904055 1.1227588854989503 0.13900848925028397 1.1199260769015285 0.543914413816189 4.40213224064678 0.4436721543199771 1.240432610358168 2.3128359722806395e-07 6.635855166563319 -1.5924447505914552 TSLSAPPNSSSTENPKTVAK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSLSAPPNSSSTENPKTVAK 20 1 Q16666;Q16666-2;Q16666-3;H3BR88;H3BR65 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 15557100.0 1702800.0 1234300.0 12620000.0 True False 1648745.546065595 1727162.4267894689 9314443.408115288 1.0 1.0475615421136393 5.649412324626056 20.652937331498336 -6.909157866702069 0.9014243536829532 0.8536935005579682 6.233586519156519 0.9906004528674328 0.21141483678569137 0.10497835234180901 0.14179763676867396 0.17237044402072196 0.4731051346431485 1.2326566792113115e-07 6.909157866702069 5.379893018598551 up TSLSPGSGMVTHYLSSSGVLPYLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSLSPGSGMVTHYLSSSGVLPYLSK 25 0 P48200 P48200 IREB2 Iron-responsive element-binding protein 2 0 15734300.0 6431200.0 2465000.0 6838100.0 False True 6227045.076260901 3449287.3548051864 5046996.471397233 1.0 0.5539204088877978 0.8104962160363481 22.57011629194111 -10.19791158112716 5.547388529345253 1.0000112887651682 0.6822083124620496 0.6716430916096647 0.10474663464286474 1.4624807541630593e-05 2.1147630616959555e-06 0.10142409221479931 0.03380683096191192 6.339987751833228e-11 10.19791158112716 -0.3178029763031186 TSLSPGSGMVTHYLSSSGVLPYLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSLSPGSGMVTHYLSSSGVLPYLSK 25 0 P48200 P48200 IREB2 Iron-responsive element-binding protein 2 0 13895200.0 6431200.0 2651900.0 4812100.0 False True 5347827.750467369 2637613.6883390658 5818287.861363483 1.0 0.49321216228562215 1.0879721884937297 22.350521567375385 -6.6809680911406195 1.8980554576857593 0.6796417107604411 1.0857492092740193 0.328780385742495 0.21474105400081192 0.43634916591669975 3.0400273939234284 0.090746817213645 0.2390766015522482 2.0846440422387866e-07 6.6809680911406195 0.4061074985135782 TSLTVVLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSLTVVLLR 9 0 P32942;K7ERN2 P32942 ICAM3 Intercellular adhesion molecule 3 0 16511600.0 3912300.0 4981000.0 7618300.0 False True 5129063.186767097 4237854.215785925 6830031.395893792 1.0 0.8262433238723834 1.3316333114232568 22.290263913825996 -6.8138922242273825 1.398121326865761 0.9057294163475681 1.3412830238950288 0.8697394172414296 0.07566734488439392 0.20154439966364293 0.7757035146511729 0.042546426761015874 0.0982561787654199 1.5349978650392852e-07 6.8138922242273825 0.43555360754746075 TSLTVVLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSLTVVLLR 9 0 P32942;K7ERN2 P32942 ICAM3 Intercellular adhesion molecule 3 0 23236400.0 11402000.0 6793500.0 5040900.0 False True 11040049.751139268 9506179.977634484 3720537.066241551 1.0 0.8610631466269889 0.3370036503556167 23.396243337737054 -6.946224820542601 0.5988598741091715 1.005917867333306 0.16537469759833834 0.9988707161677072 0.009593609718847462 0.08503806781742279 0.04251615312928128 0.009857420290160604 0.04402431916097007 1.1318143070218864e-07 6.946224820542601 -0.8405431697349677 down TSLTVVLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSLTVVLLR 9 0 P32942;K7ERN2 P32942 ICAM3 Intercellular adhesion molecule 3 0 60864000.0 16352000.0 24328000.0 20184000.0 False True 24807179.49132972 19986478.324468408 16194623.553038543 1.0 0.8056731452059602 0.6528200256985554 24.564254378273507 -6.973823543194124 0.13927666156248436 1.2068634251065702 0.24764508108007102 0.9999989470213311 0.00014567280389635087 0.07508037921647469 0.004215045700489085 0.008705432069235797 0.019971995693193682 1.0621270189815713e-07 6.973823543194124 -0.9592183440264992 TSLTVVLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSLTVVLLR 9 0 P32942;K7ERN2 P32942 ICAM3 Intercellular adhesion molecule 3 0 26843400.0 3912300.0 7874100.0 15057000.0 False True 5358783.035932123 7526196.225833351 11500846.708648996 1.0 1.4044599632730272 2.1461676338699736 22.353473975348887 -6.961705199769598 0.4106958085037191 0.9637390081484201 2.6144453162317367 0.9998283062479304 0.006219099326950445 0.07909752672422575 0.018921437408100185 0.009552727433263472 0.06191315733019246 1.0921814605142956e-07 6.961705199769598 1.6507063080833166 up TSLTVVLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSLTVVLLR 9 0 P32942;K7ERN2 P32942 ICAM3 Intercellular adhesion molecule 3 0 20043900.0 11402000.0 3098900.0 5543000.0 False True 9481268.194245085 3082205.6106165093 6702015.672063706 1.0 0.32508368579715297 0.7068691165314444 23.17664861317133 -10.732938060819226 6.968693512905178 1.00666490146801 0.5159764011647512 0.6818381062436314 0.15586324942128404 0.016176639972430396 0.0006199382112380879 0.15126100834266284 0.05030464744120046 1.8495323809102893e-11 10.732938060819226 -0.49068850030325883 TSLTVVLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSLTVVLLR 9 0 P32942;K7ERN2 P32942 ICAM3 Intercellular adhesion molecule 3 0 53949000.0 16352000.0 22329000.0 15268000.0 False True 21167986.346108764 21086371.52123151 12489380.662909424 1.0 0.996144421885823 0.5900126945804319 24.335380700365956 -6.908977797332125 0.9026691977262548 1.0129847689809544 0.5386588380593427 0.9905300347543973 0.018720005184621615 0.10509782008870971 0.14246313912004446 0.015249277557412256 0.04180258506701499 1.2331678755148596e-07 6.908977797332125 -0.4743259309216117 TSLVQLLAHLTGHTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSLVQLLAHLTGHTLK 16 0 Q9NU22 Q9NU22 MDN1 Midasin 0 96438000.0 32627000.0 28605000.0 35206000.0 False True 49497544.353205286 23500214.258114904 28247518.668662034 1.0 0.47477535633731116 0.5706852539409427 25.56085361693243 -10.092078447042425 5.399766823029197 1.0000059730891628 0.5227303051389466 0.9706030639478833 0.03915505173623064 2.8155951233899274e-06 4.734215268008315e-07 0.03791219015158408 0.012637238607716908 8.089497645833379e-11 10.092078447042425 -0.47727566795021625 TSLVQLLAHLTGHTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSLVQLLAHLTGHTLK 16 0 Q9NU22 Q9NU22 MDN1 Midasin 0 25882800.0 3533000.0 9195800.0 13154000.0 False True 2937846.038437808 9146260.400176605 15904440.582775751 1.0 3.1132538194683974 5.413639916689744 21.48632736092892 -6.970038781230167 0.2572577075917423 0.332153126997406 8.26274667221645 0.9999826838645015 0.007500266782571695 0.07629009342750714 0.008985082917632803 0.0488851864015021 0.21794991958363377 1.0714236259618406e-07 6.970038781230167 7.930593545219043 TSLVQLLAHLTGHTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSLVQLLAHLTGHTLK 16 0 Q9NU22 Q9NU22 MDN1 Midasin 0 66120000.0 32627000.0 15588000.0 17905000.0 False True 42236294.67432051 14720514.097046733 14646473.720814342 1.0 0.34852759245466536 0.3467745888637181 25.33197993902488 TSMTEEYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSMTEEYR 8 0 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 6158200.0 1870500.0 1180000.0 3107700.0 False True 1811122.001359933 1651180.1536187069 2293700.1409984087 1.0 0.911689081342323 1.2664525853455029 20.788452302154816 -6.840807711060076 1.2786650363191807 0.953025208326806 1.2783070091456976 0.925831329960661 0.04106747331057334 0.16785631005738993 0.5327618677646712 0.025181092596282297 0.058024632967264095 1.4427540062680018e-07 6.840807711060076 0.3252818008188916 TSMTEEYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSMTEEYR 8 0 A0A087WTP3;Q92945;M0R0I5 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 4005620.0 1870500.0 1478400.0 656720.0 False True 1555403.6272000873 1470435.565760577 794037.1156697972 1.0 0.9453723394020478 0.5105022913564623 20.568857577589093 -6.930188906760609 0.745250119768085 1.0065672637659024 0.4207978579275454 0.9965749975877864 0.012817468310570472 0.09254028852489964 0.07720353707075502 0.011690374133488472 0.03930760227387965 1.1743866163091346e-07 6.930188906760609 -0.585769405838357 TSNLLLSHAGILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSNLLLSHAGILK 13 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 14353900.0 4079700.0 4958200.0 5316000.0 False True 5348526.2078709975 4218455.886912221 4765951.31467274 1.0 0.7887136984959067 0.8910774911524358 22.350709979433894 -10.071472201514272 4.562677669432219 1.0000092860324716 0.8398955948173897 0.7653553863264004 0.041789843380540315 58014356.9396555 0.11237117007782355 5659.750019157531 0.014305774930378844 8.482576763134586e-11 10.071472201514272 -0.1601136912150819 TSNLLLSHAGILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSNLLLSHAGILK 13 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 12176100.0 5351800.0 2004500.0 4819800.0 False True 5181910.038427215 2804907.303329404 3557349.7890993757 1.0 0.5412883053795225 0.6864939303691738 22.30505253886736 -10.901658007445073 11.185680324991667 1.0306681586391993 0.6138911178743482 0.9040987171408935 0.05927994816776192 0.03014431795790334 0.00026502159284732884 0.03816268272907171 0.01913252100148174 1.2541283708525732e-11 10.901658007445073 -0.416777040764851 TSNLLLSHAGILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSNLLLSHAGILK 13 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 14394400.0 4079700.0 4018000.0 6296700.0 False True 5588075.339747019 3840471.474250824 4809549.144607171 1.0 0.6872619355960022 0.8606807983417252 22.413920040956786 -10.491917873712733 8.005686627292631 1.000019347085782 0.7739713669688644 0.6937236232967332 0.07079795425012869 2.4449798587057267e-05 1.5517361604838307e-06 0.06855568343585812 0.022849941479691906 3.221677961893596e-11 10.491917873712733 -0.22604798011691773 TSNLLLSHAGILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSNLLLSHAGILK 13 0 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q9UQ88-9;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 0 10537000.0 5351800.0 2889200.0 2296000.0 False True 4450258.824939557 2873635.3061387013 2776082.9844954535 1.0 0.6457231858144185 0.623802590747777 22.085457814301638 -13.999999999999998 0.39579009475746774 6.8127911408347055 0.6223868863587025 0.9998317288513731 0.0022364432013339845 26.158414332640188 0.20685508453632542 130.3734632555093 0.005675024264842658 1.0000000000000041e-14 13.999999999999998 -6.190404254476003 TSNLLLSHAGILK(ub)VGDFGLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSNLLLSHAGILKVGDFGLAR 21 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 15107200.0 2077800.0 5426800.0 7602600.0 True False 2011841.3763302155 7593749.540388143 5611250.986888852 1.0 3.774526973016055 2.7891120308521997 20.940085129635012 -10.300704227494633 5.895694066934148 0.9998280366959329 3.2818195019341183 0.8772899509533355 0.4022939655359658 0.0009094052417645308 0.00010786532342292971 0.389546664751577 0.12983981906670766 5.003751951662872e-11 10.300704227494633 2.2819914652381854 TSNLLLSHAGILK(ub)VGDFGLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSNLLLSHAGILKVGDFGLAR 21 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 43910900.0 8065700.0 5320200.0 30525000.0 True False 12236256.581654701 4370768.743087674 24491720.37041723 1.0 0.3571981932481361 2.001569696334794 23.544658928361493 -6.800681261633195 1.4531010253614847 0.6456401119523698 2.0246587382627577 0.8341480517197861 0.275551715386421 0.21979130733803617 0.9161518371376133 0.14917502981585415 0.3467875673062081 1.5824089782963962e-07 6.800681261633195 1.3790186263103879 up TSNLLLSHAGILK(ub)VGDFGLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSNLLLSHAGILKVGDFGLAR 21 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 5201400.0 2077800.0 1297400.0 1826200.0 True False 1727782.7621472017 1290410.6486862637 2208049.976605225 1.0 0.7468593141203737 1.2779673608163398 20.720490405069288 -6.777137244745294 1.5474138821299284 0.8561295497827945 1.2817739100296428 0.7569866785988679 0.10692528131999786 0.25505431435519194 1.2061487404138778 0.05443978114442947 0.12874505593140595 1.6705626035253575e-07 6.777137244745294 0.42564436024684826 TSNLLLSHAGILK(ub)VGDFGLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSNLLLSHAGILKVGDFGLAR 21 1 P21127;P21127-6;A0A0D9SER5;A0A0D9SEI3;P21127-8;P21127-2;A0A0D9SEN2;P21127-3;P21127-9;P21127-10;P21127-5;P21127-4;P21127-12;Q5QPR4;Q5QPR3;Q9UQ88-10;Q9UQ88-4;Q9UQ88-3;Q9UQ88-2;Q9UQ88;Q9UQ88-5 P21127;Q5QPR4 CDK11B;CDK11A Cyclin-dependent kinase 11B;Cyclin-dependent kinase 11A 1 78072400.0 8065700.0 7457700.0 62549000.0 True False 10441207.648716308 7042672.439154825 51165723.80693757 1.0 0.6745074589164679 4.900364548657178 23.315785250453942 -6.888302878362445 1.0323436965597308 0.7636167381359826 5.252003141536732 0.9797905878094277 0.2729429609009347 0.1205319869146031 0.2299643444360371 0.2018829278252676 0.5003307701231384 1.293293579782339e-07 6.888302878362445 4.4883864034007495 up TSNNSQVNK(ub)LTLTSDESTLIEDGGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSNNSQVNKLTLTSDESTLIEDGGAR 26 1 Q9NRX5 Q9NRX5 SERINC1 Serine incorporator 1 1 32017100.0 5473100.0 0.0 26544000.0 True False 8303092.837206243 0.0 21297566.765351485 1.0 0.0 2.565016094956433 22.985217398526213 -6.800988583655341 1.4519841248240946 0.448942142405864 2.601245696215317 0.8349974794841802 0.4287891819288707 0.21935692692988168 0.9129242149864615 0.23231496848550798 0.5399300166082741 1.581289606250002e-07 6.800988583655341 2.152303553809453 TSNNSQVNK(ub)LTLTSDESTLIEDGGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSNNSQVNKLTLTSDESTLIEDGGAR 26 1 Q9NRX5 Q9NRX5 SERINC1 Serine incorporator 1 1 43406100.0 5473100.0 18712000.0 19221000.0 True False 7085035.84093002 17670660.75083002 15722975.22411462 1.0 2.494082055131915 2.219180760284021 22.756343720618663 -10.090312047238243 4.483934920798686 0.999888415808767 2.3566314077540484 0.9701242735668766 0.11222798390613388 19511360.42333052 5.474788063845432 22784.67056117329 0.03841862394495811 8.122466947538443e-11 10.090312047238243 1.3567429919452816 TSNVLTLSLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSNVLTLSLK 10 0 K7EMM6;E9PEW0;A0A075B784;Q9P275 K7EMM6 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 0 4331600.0 1456300.0 1511000.0 1364300.0 False True 1909223.402829261 1285564.68983187 1223135.3232896966 1.0 0.6733442969150719 0.6406454695019679 20.864554495165283 -13.999999999999998 0.32533166229860677 4.457553942378632 0.634533152937787 0.9997050702274243 0.0027862992275296886 18.436590799513457 0.18215192608884362 43.51089913509769 0.010664680595990432 1.0000000000000041e-14 13.999999999999998 -3.823020789440845 TSNVLTLSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSNVLTLSLK 10 0 K7EMM6;E9PEW0;A0A075B784;Q9P275 K7EMM6 USP36 Ubiquitin carboxyl-terminal hydrolase;Ubiquitin carboxyl-terminal hydrolase 36 0 5340100.0 1456300.0 1756700.0 2127100.0 False True 1994733.4650277193 1679083.1853699416 1624722.7889996222 1.0 0.841758167097582 0.8145062072125233 20.927764556688174 -13.999999998896232 0.24746048177067756 2.086568522808366 0.8032808458769253 0.9995379764127982 0.0017578207903943199 13.898762971888843 0.15741691486489368 7.495631269273153 0.012756714607626304 1.0000000025415191e-14 13.999999998896232 -1.2832876769314407 TSPALHPEQK(ub)ADR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSPALHPEQKADR 13 1 Q9H1I8;B1AH59 Q9H1I8 ASCC2 Activating signal cointegrator 1 complex subunit 2 1 5343880.0 456980.0 1163000.0 3723900.0 True False 693272.0697130535 955453.5634395254 2987869.5327566476 1.0 1.3781798015243703 4.309808029614307 19.403062113373796 -6.930686979030573 0.7411320763031426 0.9565362588450657 4.922321038683905 0.996671548172355 0.08533909425171476 0.09228263759645804 0.0759442549904053 0.07806818383533663 0.2642667185393866 1.1730405385989765e-07 6.930686979030573 3.9657847798388395 up TSPALHPEQK(ub)ADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSPALHPEQKADR 13 1 Q9H1I8;B1AH59 Q9H1I8 ASCC2 Activating signal cointegrator 1 complex subunit 2 1 6155480.0 456980.0 1018900.0 4679600.0 True False 591569.6184225037 962197.3193149177 3827960.8167507877 1.0 1.6265157799698036 6.470854312901559 19.174188435466245 -6.930735240285115 0.7407314199292622 0.9283044340842959 7.484254324389626 0.9966807705536656 0.14084768318085292 0.0922579804089778 0.0758229543704064 0.1288844509379442 0.43657089592643844 1.172910190954805e-07 6.930735240285115 6.55594989030533 up TSQETADVK(ub)ASVLLGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSQETADVKASVLLGSR 17 1 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 10939500.0 1973700.0 4893700.0 4072100.0 True False 2587539.8133379915 4163579.035493196 3650758.1543413945 1.0 1.609087912012482 1.4108993166106398 21.303149630221505 -10.130190405364825 4.599222701070149 0.9999545234477748 1.5099936142573915 0.8982601184451457 0.08091015535707599 56488810.33098512 2.9526815950641594 30477.10440579971 0.02769769824788561 7.409853039239684e-11 10.130190405364825 0.5100390908096167 TSQETADVK(ub)ASVLLGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSQETADVKASVLLGSR 17 1 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 45552100.0 10045000.0 7157100.0 28350000.0 True False 15238999.387867324 5879859.586322469 22746610.073753607 1.0 0.38584289143050793 1.4926577194998472 23.861264840956537 -6.756076576741261 1.6270706385241107 0.6415273870120243 1.4959586506030975 0.6748015900546103 0.2581927443671611 0.2895647122919486 1.509875870986692 0.12525625067520108 0.3022083296494847 1.753571277067034e-07 6.756076576741261 0.8544312635910732 TSQETADVK(ub)ASVLLGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSQETADVKASVLLGSR 17 1 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 11824900.0 1973700.0 4225500.0 5625700.0 True False 2703430.2272369806 4038803.4381400845 4297025.52492839 1.0 1.4939551231798986 1.5894715837812212 21.366359691744396 -11.745905388587637 0.27639853104478157 9.594384694759018e-11 1.6227164263582992 0.9993759909670551 0.006453030401578113 4.513152718369773 0.15337254489650554 2.670992146449445 0.03836590817036956 1.7951246536299026e-12 11.745905388587637 1.6227164262623552 TSQETADVK(ub)ASVLLGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSQETADVKASVLLGSR 17 1 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 20208700.0 5085200.0 9477300.0 5646200.0 True False 4228569.11255701 9426243.903803237 6826794.3149208175 1.0 2.229180522510888 1.6144454857432056 22.01173812783505 -10.094575119934678 5.593424856661793 0.9999920527514344 1.9218130041272519 0.7498822085131716 0.2509645278493703 2.4872252002046165e-05 4.025949567742197e-06 0.24299745312724175 0.08099845307067965 8.043126145329337e-11 10.094575119934678 0.9218209513758174 TSQETADVK(ub)ASVLLGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSQETADVKASVLLGSR 17 1 Q8N1F7;H3BVG0;H3BRI8;H3BM93;H3BNN5;H3BV11 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 34739600.0 10045000.0 9797600.0 14897000.0 True False 13003450.51655223 9252354.947217429 12185898.85612797 1.0 0.71153075373648 0.937128098470203 23.632391163048986 -9.861452315781026 5.7056401901347344 1.0000000560474458 0.8243294267262338 0.4470491865037711 0.09209973032244648 6.562245327352697e-08 1.3042115037394844e-08 0.08917520833655285 0.029725060143835646 1.3757758580059216e-10 9.861452315781026 -0.17567062932121202 TSQLGDSPFYPGK(ub)TTYGGAAAAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSQLGDSPFYPGKTTYGGAAAAVR 24 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 10306300.0 3098000.0 4848100.0 2360200.0 True False 4061508.001074677 4124782.3777457844 2115989.14463706 1.0 1.015579035337211 0.520986083020683 21.953584055782528 -6.8996249038812225 0.9636125478245474 1.0207755471467006 0.46945960391717645 0.9863794511202062 0.026792386826289035 0.11168272302629391 0.17897087248369656 0.02086741422634937 0.054193398463486586 1.2600132036943002e-07 6.8996249038812225 -0.5513159432295242 TSQLGDSPFYPGK(ub)TTYGGAAAAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSQLGDSPFYPGKTTYGGAAAAVR 24 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 19742800.0 6076500.0 6635800.0 7030500.0 True False 5883604.833607939 9285509.545239855 5189001.139520963 1.0 1.5782007473037245 0.8819424972052325 22.488268922011585 -6.686272280090778 1.8798039731478684 1.3637619832343042 0.8844624166176576 0.3529336851275666 0.24472777467367118 0.42475339632249337 2.9070761692940685 0.10426659449371728 0.27278587754827127 2.0593384102010962e-07 6.686272280090778 -0.47929956661664663 TSQLGDSPFYPGK(ub)TTYGGAAAAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSQLGDSPFYPGKTTYGGAAAAVR 24 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 18707800.0 6076500.0 10021000.0 2610300.0 True False 5052878.984593074 9967014.883987248 3156101.6613364466 1.0 1.972541775565584 0.6246145357844185 22.26867419744586 -6.713085259741846 1.7839102450684077 1.5959848626691986 0.6274397531229406 0.4799076881978288 0.40963005419181614 0.3688921210094325 2.2901779931413255 0.18259281625365584 0.4621958823141095 1.9360418471393032e-07 6.713085259741846 -0.9685451095462579 TSQLIPEMQEAFFQCQVCAHTTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSQLIPEMQEAFFQCQVCAHTTR 23 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 31998000.0 12095000.0 10497000.0 9406000.0 False True 15657215.928093525 9912832.72239541 7694204.513710113 1.0 0.6331159235409759 0.4914158780875283 23.90032436829562 -13.999999999999984 0.13169062332742396 2.744103659934451 0.29717047653290035 0.9996380305749173 0.004077259060645788 11.934510070994643 0.11301472792744342 5.379882742719792 0.1728645441504985 1.0000000000000368e-14 13.999999999999984 -2.446933183401551 TSQTVATFLDELAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSQTVATFLDELAQK 15 0 P52888;K7EP46 P52888 THOP1 Thimet oligopeptidase 0 4632880.0 727180.0 1935100.0 1970600.0 False True 953340.0220211383 1646390.6229607218 1766701.215329969 1.0 1.72697105432569 1.8531700909655047 19.862631337672635 -11.1710410554344 0.31747948128303866 5.635052117731744e-19 1.8836227352646076 0.9993332598548967 0.009708538038371753 3.1896640374678102 0.16329342849398867 2.31565192085112 0.04231108317854172 6.744642651279932e-12 11.1710410554344 1.8836227352646076 TSQTVATFLDELAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSQTVATFLDELAQK 15 0 P52888;K7EP46 P52888 THOP1 Thimet oligopeptidase 0 5029780.0 727180.0 1477300.0 2825300.0 False True 996038.0973005965 1412028.0012221853 2158022.328879993 1.0 1.4176445710751224 2.1666062118793823 19.925841399195527 -6.962120841737801 0.4044351609115143 0.9607895541864059 2.651005732663645 0.9998409497515427 0.006086626417041127 0.0789520383047871 0.018394688918461584 0.00963537908687148 0.06265011443112581 1.0911366871857464e-07 6.962120841737801 1.6902161784772392 up TSQTVATFLDELAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSQTVATFLDELAQK 15 0 P52888;K7EP46 P52888 THOP1 Thimet oligopeptidase 0 6980700.0 2701600.0 1793900.0 2485200.0 False True 2246500.101172821 1784235.9046387288 3004843.8297334886 1.0 0.7942291672754611 1.3375667457859282 21.099247696158383 -6.804102316378418 1.4392417007335956 0.8870516552134915 1.3458371579590227 0.8438512504046158 0.08850769811899531 0.21495403161087903 0.8785943099694561 0.04837087253395592 0.1122167507992093 1.5699928827334082e-07 6.804102316378418 0.4587855027455312 TSQTWHGGIATIFQSPGDEVWGVVWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSQTWHGGIATIFQSPGDEVWGVVWK 26 0 O75223;B8ZZK2;H7BZK5;O75223-2;O75223-4 O75223 GGCT Gamma-glutamylcyclotransferase 0 62993000.0 16348000.0 22918000.0 23727000.0 False True 24801111.19889055 18828103.840848695 19037348.050086465 1.0 0.7591637201195627 0.7676006085944278 24.563901425356544 -10.03924106503079 4.887990315851283 1.0000047628522286 0.763382164353983 0.9990473832040672 0.003444345307101688 1.787790598382143e-07 3.5142782065013004e-08 0.003335040103007803 0.0011116576662662946 9.136059829185648e-11 10.03924106503079 -0.23662259849824563 TSQVPVK(ub)HVYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSQVPVKHVYR 11 1 Q9NXV2 Q9NXV2 KCTD5 BTB/POZ domain-containing protein KCTD5 1 2566560.0 931040.0 1180700.0 454820.0 True False 1220602.456204186 1004544.1623325524 407759.5893415083 1.0 0.8229904480583065 0.33406420515452173 20.21916196796956 -6.953291498936327 0.5214580490936801 1.008215509682194 0.1269656211216095 0.9994349158313679 0.006694823992026759 0.0821903489199798 0.03069614978406398 0.007566897560204715 0.040391495192070116 1.1135468688138126e-07 6.953291498936327 -0.8812498885605846 down TSQVPVK(ub)HVYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSQVPVKHVYR 11 1 Q9NXV2 Q9NXV2 KCTD5 BTB/POZ domain-containing protein KCTD5 1 2582310.0 931040.0 831580.0 819690.0 True False 1275270.6484099491 794838.0459326779 626096.1040454606 1.0 0.6232700853922335 0.4909515519910213 20.28237202949245 -13.999999999999998 0.14584116645416587 2.810996715840156 0.33817684446608554 0.9995807076330749 0.004415885055924951 11.944526274554947 0.12004231653305569 6.138838013041528 0.13718497806783977 1.0000000000000041e-14 13.999999999999998 -2.47281987137407 TSRPENAIIYNNNEDFQVGQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSRPENAIIYNNNEDFQVGQAK 22 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 122340000.0 17390000.0 46578000.0 58372000.0 False True 22798458.40499954 39628743.95962199 52332225.383761756 1.0 1.7382203329560075 2.295428245810062 24.442432939186908 -6.9905701220588465 0.12039483010269968 7.917096410831872e-10 4.038886139396171 0.9999994768402276 0.0003837200026512194 0.07333602815746103 0.0035536484819579262 0.03889039207735784 0.07905226086558798 1.0219505410924222e-07 6.9905701220588465 4.038886138604461 TSRPENAIIYNNNEDFQVGQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSRPENAIIYNNNEDFQVGQAK 22 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 106074000.0 31180000.0 22511000.0 52383000.0 False True 30190207.967069104 31499759.693314184 38662320.84368484 1.0 1.0433767043828752 1.2806245285178872 24.84757735918914 -6.9378244972438745 0.6794986287004005 0.9972102277430586 1.3407062957277869 0.9978648852636854 0.005699276323308838 0.08877318531257572 0.05923471463341727 0.00546032555367767 0.02062279051717666 1.153919474046735e-07 6.9378244972438745 0.3434960679847283 TSRPENAIIYNNNEDFQVGQAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSRPENAIIYNNNEDFQVGQAK 22 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 365452000.0 48547000.0 276940000.0 39965000.0 False True 73649348.26110451 227517893.25790372 32065900.232718263 1.0 3.089204434658383 0.435386069120897 26.13416942281098 -6.69673294467067 1.842268594542307 2.3013457047660633 0.4436181764893172 0.40239884830085926 0.8823995022111234 0.4022425097780601 2.651723037627282 0.38243461116740834 0.9875989301890264 2.010328619100714e-07 6.69673294467067 -1.857727528276746 TSRPENAIIYNNNEDFQVGQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSRPENAIIYNNNEDFQVGQAK 22 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 123366000.0 17390000.0 44890000.0 61086000.0 False True 23819552.9470796 42906611.36862111 46658744.905660674 1.0 1.801318919122774 1.9588421751375178 24.5056430007098 -10.99863840536511 0.3061334798830954 1.1390555111801308e-13 2.0026830362738623 0.9992564903496404 0.011447619648835922 2.8736404565482383 0.1562686363544885 2.081738109513921 0.05523886816270188 1.0031401073495538e-11 10.99863840536511 2.0026830362737487 TSRPENAIIYNNNEDFQVGQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSRPENAIIYNNNEDFQVGQAK 22 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 60723000.0 31180000.0 16454000.0 13089000.0 False True 25927551.5082057 16365359.036136705 15825849.3833018 1.0 0.6311957004870785 0.6103873471543637 24.627982634623415 -13.999999999999998 0.40942884246221123 7.60628119567312 0.609430555917456 0.9998506716496302 0.002186911606287302 28.214979549771787 0.2120446350144292 166.15857954602458 0.005190182725203003 1.0000000000000041e-14 13.999999999999998 -6.996850639755665 TSRPENAIIYNNNEDFQVGQAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSRPENAIIYNNNEDFQVGQAK 22 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 130296000.0 48547000.0 40292000.0 41457000.0 False True 62845048.50443614 38049714.780485496 33912251.38474174 1.0 0.6054528667886957 0.5396169179875471 25.90529574490343 -13.999999999999174 0.25194726651678007 3.7710470331486516 0.5136313634736321 0.999546382231398 0.0043298039816282476 14.076019900438544 0.15882983912785295 19.763408080245366 0.030057484116647618 1.000000000001902e-14 13.999999999999174 -3.2574156696750194 TSSAEVTIQNVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSSAEVTIQNVIK 13 0 P48960-2;P48960-3;P48960 P48960-2 CD97 CD97 antigen;CD97 antigen subunit alpha;CD97 antigen subunit beta 0 5983100.0 1849700.0 2104100.0 2029300.0 False True 2424974.6125202817 1790176.4817175611 1819327.5024201279 1.0 0.7382248343858028 0.7502459997011254 21.20953821287845 -9.776722922797127 5.967720288531826 1.0000000128134205 0.7442354170458739 0.9983459248271739 0.004907620191968745 8.328777650710005e-10 1.7797521882544915e-10 0.004751783029528889 0.0015839276057025968 1.6721570999930836e-10 9.776722922797127 -0.2557645957675466 TSSAEVTIQNVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSSAEVTIQNVIK 13 0 P48960-2;P48960-3;P48960 P48960-2 CD97 CD97 antigen;CD97 antigen subunit alpha;CD97 antigen subunit beta 0 5314700.0 1849700.0 1498300.0 1966700.0 False True 2533584.076262978 1432100.1517844745 1502205.9654579253 1.0 0.565246744799886 0.5929173535356563 21.27274827440134 -10.723684600688973 6.812346881200372 1.005518754701525 0.5790820491678051 0.9967692856844748 0.011296478712472668 0.0009521299595808196 3.861927090790546e-05 0.010998720352992137 0.0036459228270160995 1.8893629701357872e-11 10.723684600688973 -0.4264367055337198 TSSAFVGK(ub)TPEASPEPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSSAFVGKTPEASPEPK 17 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 488910000.0 139880000.0 123590000.0 225440000.0 True False 183384034.59984678 105150853.7500467 202113631.3731797 1.0 0.5733915385790872 1.102133191769948 27.450292802578037 -6.691965680451899 1.859205989473651 0.7330440796473879 1.1003626470949954 0.37976961639805284 0.18035299831104248 0.4124429949761658 2.7655711159596508 0.07755534459746793 0.2014772986532136 2.0325176216119461e-07 6.691965680451899 0.3673185674476075 TSSAFVGK(ub)TPEASPEPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSSAFVGKTPEASPEPK 17 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 661015300.0 143680000.0 221005300.0 296330000.0 True False 139118957.0464556 309253868.8174139 218712283.2905549 1.0 2.222945566750804 1.5721242304707685 27.0517437812325 -10.052259244496865 4.981659149975549 0.9999845326133856 1.8975348986139569 0.7171799103870893 0.26569669795719686 5.0315458115267525e-05 9.57160838208899e-06 0.25726459531263546 0.08575324052417643 8.866265977974616e-11 10.052259244496865 0.8975503660005713 TSSAFVGK(ub)TPEASPEPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSSAFVGKTPEASPEPK 17 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 1478446000.0 391490000.0 743210000.0 343746000.0 True False 593918951.7527305 610578368.7737654 275804452.4307758 1.0 1.0280499838772124 0.4643806223338079 29.145690828370327 -6.895193094578155 0.9911740044309028 1.0266250613954027 0.4106687267603251 0.9840187189543256 0.032787254267335884 0.11502999033750172 0.19805258544833734 0.025017065833786288 0.06365303483978481 1.272936986139852e-07 6.895193094578155 -0.6159563346350776 down TSSAFVGK(ub)TPEASPEPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSSAFVGKTPEASPEPK 17 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 426448000.0 139880000.0 120728000.0 165840000.0 True False 191597416.11486453 115393837.76589198 126672007.58201173 1.0 0.6022724111097211 0.6611363041872684 27.51350286410093 -10.431996892840495 5.992520219769625 1.0001453538286944 0.631704357648541 0.9812014533771336 0.024031083718956736 4.668535608932816e-05 4.425102065717605e-06 0.023277085576798796 0.007755998919569571 3.698308257251324e-11 10.431996892840495 -0.36844099618015336 TSSAFVGK(ub)TPEASPEPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSSAFVGKTPEASPEPK 17 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 631864000.0 143680000.0 328354000.0 159830000.0 True False 119476286.10323898 326585091.828834 193249714.0295767 1.0 2.733472076179478 1.617473394365392 26.832149056666776 -10.470230997362714 4.946376296096305 0.9971830721534815 2.175472735272519 0.5966493960499649 0.45560455401081607 0.014172300787707162 0.0015178845575993007 0.4417345961194658 0.14704573751163735 3.386639758761039e-11 10.470230997362714 1.1782896631190374 TSSAFVGK(ub)TPEASPEPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSSAFVGKTPEASPEPK 17 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 1508740000.0 391490000.0 926340000.0 190910000.0 True False 506791522.42160594 874788364.6816959 156166338.90201983 1.0 1.7261306197500854 0.3081471019006178 28.916817150462776 -6.767501904358493 1.5839606306715777 1.417817106985949 0.30090325219559316 0.720931678391476 0.3058391803645848 0.2704895951143115 1.3389205324645466 0.15222774797060534 0.36321020338693527 1.7080402303765864e-07 6.767501904358493 -1.1169138547903559 TSSAQVEGGVHSLHSYEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSSAQVEGGVHSLHSYEK 18 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 48548400.0 10140100.0 18008300.0 20400000.0 False True 13293769.296868071 15321531.835803593 18289203.690617725 1.0 1.1525348073712434 1.3757726106264343 23.66424688657525 -6.965663166824732 0.3464822787475961 0.9775345970624262 1.5582651789423283 0.9999261687761154 0.0013259064409063897 0.07773664038401791 0.014070480058920759 0.003092804194632664 0.01923352471712236 1.0822730228084835e-07 6.965663166824732 0.5807305818799021 TSSAQVEGGVHSLHSYEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSSAQVEGGVHSLHSYEK 18 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 47749500.0 12951000.0 7174500.0 27624000.0 False True 12539877.594018986 10039315.26452323 20388445.69776363 1.0 0.8005911691922397 1.6258887333547891 23.5800199297866 -6.8428785911101775 1.268910706347444 0.893925419363705 1.6546261286614017 0.9293003052129643 0.09348895231203465 0.16546139386960318 0.5162573627652716 0.05774203762219642 0.1331508365855047 1.435890786694569e-07 6.8428785911101775 0.7607007092976967 TSSAQVEGGVHSLHSYEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSSAQVEGGVHSLHSYEK 18 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 130828000.0 18551300.0 93544000.0 18732700.0 False True 28143678.381696697 76850342.33739208 15030173.63416592 1.0 2.730643141067582 0.5340514992503903 24.746307565501642 -6.696631658331504 1.8428444210449753 2.078174316435452 0.5409712264946035 0.4016569777998471 0.7309834755908968 0.4025540663741521 2.6554150897362585 0.31673280471986753 0.8179684269606784 2.0107975234518255e-07 6.696631658331504 -1.5372030899408484 TSSAQVEGGVHSLHSYEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSSAQVEGGVHSLHSYEK 18 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 43864300.0 10140100.0 14389000.0 19335200.0 False True 13889168.995898893 13753246.401940059 14768623.98094375 1.0 0.9902137706007488 1.0633194819146154 23.72745694809814 -6.8731468853189375 1.1172621208182323 0.9943440634602952 1.0678659691067025 0.9677267350613441 0.005821113426358499 0.13387597921737107 0.310418926227946 0.00403513837630942 0.009609500950595777 1.3392236640222657e-07 6.8731468853189375 0.07352190564640726 TSSAQVEGGVHSLHSYEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSSAQVEGGVHSLHSYEK 18 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 30844000.0 12951000.0 12219600.0 5673400.0 False True 10769330.326580245 12153770.589399308 6859681.709162229 1.0 1.1285539788302403 0.6369645559326521 23.360425205220878 -6.837218526448159 1.2951501653682584 1.0684335351277898 0.6216562415227367 0.9195804105035452 0.05903117185015776 0.17207355733085905 0.561865473996824 0.03575412056162747 0.08232389271995817 1.4547269130991145e-07 6.837218526448159 -0.44677729360505314 TSSAQVEGGVHSLHSYEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSSAQVEGGVHSLHSYEK 18 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 59379500.0 18551300.0 22384300.0 18443900.0 False True 24015023.55079299 21138594.0276189 15087299.450395303 1.0 0.8802237475599266 0.628244207984427 24.51743388759409 -6.9590436340993485 0.4487085801501492 1.0082339277817323 0.490266281574779 0.9997330678366958 0.0025313230486371796 0.08004454145719525 0.022407044698669984 0.0033615598014364997 0.020846933913556145 1.0988954265144297e-07 6.9590436340993485 -0.5179676462069533 TSSAQVEGGVHSLHSYEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSSAQVEGGVHSLHSYEKR 19 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 7680800.0 1527500.0 3801100.0 2352200.0 True False 2002567.2923310394 3233990.696571755 2108816.9078956423 1.0 1.6149223593916324 1.0530567017505443 20.93341929169905 -10.360375615716265 5.607849455221138 0.9999135488214768 1.333989530570929 0.32024977194446935 0.22938069420233628 0.0002480176698605052 2.8288352014444677e-05 0.22215411678494165 0.07403230071559425 4.361384585229044e-11 10.360375615716265 0.3340759817494523 TSSAQVEGGVHSLHSYEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSSAQVEGGVHSLHSYEKR 19 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 9763000.0 3379900.0 1612600.0 4770500.0 True False 3272606.924563723 2256519.589597907 3520962.938067666 1.0 0.6895174524813203 1.0758893503646336 21.642008898856883 -6.692796152524337 1.856653013368454 0.805859550133124 1.0745952996783377 0.38350804224979584 0.13123849274925126 0.410662617289009 2.7468042324817326 0.0565045988758627 0.14661604646698545 2.0286346888456218e-07 6.692796152524337 0.2687357495452136 TSSAQVEGGVHSLHSYEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSSAQVEGGVHSLHSYEKR 19 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 11152700.0 3379900.0 5160100.0 2612700.0 True False 2810536.6049578083 5132301.517100343 3159003.490240097 1.0 1.826093105511212 1.1239858910457137 21.42241417429116 -10.278584244188808 4.570723486299171 0.9997709120179904 1.4750394981585886 0.3790236816981275 0.2866340700985387 0.0006999367802255732 0.00011047438219374009 0.2776703754698994 0.092510748318372 5.265210707388829e-11 10.278584244188808 0.4752685861405982 TSSAQVEGGVHSLHSYEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSSAQVEGGVHSLHSYEKR 19 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 24232300.0 4924400.0 4304900.0 15003000.0 True False 6374732.87443602 4065328.5306887683 12272607.943779806 1.0 0.6377253150467788 1.9251956412158804 22.603933458150447 -6.831565490010209 1.320894633993765 0.8066280895126284 1.9609645107032008 0.9089772653117633 0.1635501340241124 0.17888163826977563 0.6098424278331755 0.0972010756003214 0.22368286229006148 1.473786282666635e-07 6.831565490010209 1.1543364211905724 TSSDPTCVEK(ub)EK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSSDPTCVEKEK 12 1 O14980;C9JKM9;C9J673 O14980 XPO1 Exportin-1 1 11963490.0 4431690.0 4694400.0 2837400.0 True False 5809988.506547009 3994013.8186278795 2543813.0662626866 1.0 0.6874391944368237 0.437834440360111 22.470103878984265 -7.395469666237263 0.18028360784720462 1.2237908459568136 4.12536269565353e-10 0.9999788542504302 0.0010575467296024266 0.12017627713794427 0.013468141685542702 0.027106832672713493 0.05625960607598025 4.0228175281686895e-08 7.395469666237263 -1.2237908455442774 down TSSDPTCVEK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSSDPTCVEKEK 12 1 O14980;C9JKM9;C9J673 O14980 XPO1 Exportin-1 1 13475230.0 880630.0 4066600.0 8528000.0 True False 1335980.0926767155 3340883.4575091754 6842437.0620448105 1.0 2.5006985327270237 5.121660943566592 20.349467079822848 -6.96260620253878 0.39699845315247073 0.8510649133460645 6.866533565763195 0.9998549830491219 0.020511076907425575 0.0787829407462975 0.01778517309596221 0.03374324377354207 0.21984467265842825 1.089917930846079e-07 6.96260620253878 6.01546865241713 TSSDPTCVEK(ub)EK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSSDPTCVEKEK 12 1 O14980;C9JKM9;C9J673 O14980 XPO1 Exportin-1 1 11076190.0 4431690.0 3618200.0 3026300.0 True False 6070205.554919106 3458335.960212631 2311550.268604933 1.0 0.5697230396769848 0.38080263471996006 22.533313940507156 -13.999999999999998 0.11179919564127556 3.0699752219447496 0.04304209847265622 0.9997339353363932 0.0042264401201549855 12.00236146016473 0.10175262933803979 5.589831793658702 0.2998816912955321 1.0000000000000041e-14 13.999999999999998 -3.0269331234720935 TSSDPTCVEK(ub)EK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSSDPTCVEKEK 12 1 O14980;C9JKM9;C9J673 O14980 XPO1 Exportin-1 1 3564240.0 2051200.0 1304700.0 208340.0 True False 1705663.6835673992 1297671.3221373276 251902.9307446787 1.0 0.7608014021986124 0.147686166488474 20.701901778769646 -7.161396596114518 0.5892343168760171 1.0029473005213239 1.029936797856553e-26 0.998461825910876 0.01407761320336761 0.08287731098967069 0.04812633029966119 0.014108985647049235 0.04979508596669067 6.896097671217991e-08 7.161396596114518 -1.0029473005213239 down TSSDPTCVEK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSSDPTCVEKEK 12 1 O14980;C9JKM9;C9J673 O14980 XPO1 Exportin-1 1 14314150.0 880630.0 4078520.0 9355000.0 True False 1139992.8948124833 3851546.7766927774 7652485.990405927 1.0 3.378570861466918 6.712748847144947 20.120593401915297 -6.966358479525677 0.3339166967960787 0.6119021261052121 9.58920896304705 0.9999384716185994 0.01837905594635079 0.07750294079116157 0.01325077391762834 0.047995207713835634 0.28991457363976847 1.0805416719986883e-07 6.966358479525677 8.977306836941837 TSSGDASSLSIEETNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSSGDASSLSIEETNK 16 0 O43290;E9PQI8 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 0 2059900.0 897800.0 1162100.0 0.0 False True 1177024.4943075688 988719.2098303206 0.0 1.0 0.8400158319661595 0.0 20.166712913021144 -7.191832529604737 0.8995070147019735 0.9911810997866433 1.5645392488300216e-19 0.9894209881266872 0.04511049747906057 0.09194008135945449 0.14130419850336073 0.037970568658812175 0.06665268745837236 6.42935595025097e-08 7.191832529604737 -0.9911810997866433 down TSSGDASSLSIEETNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSSGDASSLSIEETNK 16 0 O43290;E9PQI8 O43290 SART1 U4/U6.U5 tri-snRNP-associated protein 1 0 3305300.0 897800.0 1231500.0 1176000.0 False True 1229740.9221327258 1177088.2579740898 898253.0204802566 1.0 0.9571839375180577 0.730440863041645 20.229922974544035 -6.938531840263082 0.673083690698142 1.0026213138405478 0.6718489801171079 0.9979651988715488 0.00533538464321722 0.08844289524419177 0.05770801880537054 0.005137542831432591 0.01964492460896085 1.152041594897821e-07 6.938531840263082 -0.33077233372343984 TSSSIPPIILLQFLHMAFPQFAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSSSIPPIILLQFLHMAFPQFAEK 24 0 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 0 2370900000.0 1451900000.0 318120000.0 600880000.0 False True 1879513171.2276947 300416342.3500454 491526005.5494509 1.0 0.1598373168908489 0.26151772335193957 30.80771187950196 -10.630370632428864 6.595733272600659 1.0028792392408787 0.2106775215547323 0.9877070803577828 0.04151085211141101 0.0017605717560907309 9.866343826654338e-05 0.04026212413613491 0.013397569909531164 2.3422290740875588e-11 10.630370632428864 -0.7922017176861464 TSTSQAVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSTSQAVFR 9 0 P14868;P14868-2;C9J7S3;C9JLC1 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 3357100.0 555700.0 1597700.0 1203700.0 False True 728528.0814064558 1359329.387785823 1079152.6707057145 1.0 1.865857229774283 1.4812780704655368 19.474625057056087 -10.069816564759375 4.469146134486517 0.9999557770827038 1.673567649711223 0.8035386638444649 0.157003784498016 23221449.429018866 17440750.649271753 9457.143632265617 0.05374657639953086 8.51497613777118e-11 10.069816564759375 0.6736118726285193 TSTSQAVFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSTSQAVFR 9 0 P14868;P14868-2;C9J7S3;C9JLC1 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 5827600.0 3321500.0 0.0 2506100.0 False True 5038958.334176345 0.0 2010768.236537351 1.0 0.0 0.39904442608692975 22.264694096414598 -10.702014286980484 6.690656174539812 1.008121370696496 0.1995222130434726 0.842898456921488 0.1629092047691224 0.01962785545999685 0.0008741763374716875 0.1568767521665112 0.0525787197512254 1.9860295818908156e-11 10.702014286980484 -0.8085991576530234 TSTSQAVFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSTSQAVFR 9 0 P14868;P14868-2;C9J7S3;C9JLC1 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 7680600.0 3321500.0 1888300.0 2470800.0 False True 4299747.226553339 1783214.4450508936 2021139.752548902 1.0 0.4147254131681391 0.4700601328532143 22.035820418507047 -10.769225053481824 10.807962256090399 1.0017869873653122 0.44239277379265535 0.9926683100611378 0.022590304714729028 0.0009739147408395391 2.079529609087784e-05 0.021899746729237213 0.007290989495491364 1.7012766702046418e-11 10.769225053481824 -0.5593942135726568 TSTTAEKTDEEEKEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSTTAEKTDEEEKEDR 16 2 Q9NUU7;I3L0H8;H3BTB3 Q9NUU7 DDX19A ATP-dependent RNA helicase DDX19A 0 7058940.0 460940.0 3442300.0 3155700.0 False True 604296.8037493089 2928722.2579803034 2829178.435611882 1.0 4.846496357103482 4.681769650374586 19.20489778578233 -10.102848077088101 4.385916280285617 0.9995642752241349 4.7641330040074426 0.9985657130754795 0.06724939734224442 11798688.156369131 20488503.201201014 70195.03783834967 0.02461075680376396 7.891361213339273e-11 10.102848077088101 3.7645687287833076 TSTTAEKTDEEEKEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSTTAEKTDEEEKEDR 16 2 Q9NUU7;I3L0H8;H3BTB3 Q9NUU7 DDX19A ATP-dependent RNA helicase DDX19A 0 5474320.0 1436520.0 630900.0 3406900.0 False True 1390918.4589112918 882821.6601000368 2514530.685190805 1.0 0.6347041082415746 1.8078203427963662 20.407606415248562 -6.8230478448281175 1.3585928706195052 0.8036856374211611 1.8351510142341076 0.8912469069460313 0.16164011169087517 0.1895596424127518 0.6866492366439548 0.09347225227832649 0.215288063691944 1.502976378888982e-07 6.8230478448281175 1.0314653768129465 TSTTAEKTDEEEKEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSTTAEKTDEEEKEDR 16 2 Q9NUU7;I3L0H8;H3BTB3 Q9NUU7 DDX19A ATP-dependent RNA helicase DDX19A 0 8392640.0 460940.0 4376000.0 3555700.0 False True 631361.9744351273 4182653.850503137 2715916.891940181 1.0 6.62481115408528 4.3016795466183755 19.26810784730522 -9.707715299144704 6.465567418148833 0.9999999805219536 5.463245350356447 0.8311223006888838 0.9484145072874961 2.706376028806228e-07 5.079354644503781e-08 0.9182983979990861 0.30609946599972276 1.9601292110989883e-10 9.707715299144704 4.463245369834493 TSTTSSMVASAEQPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSTTSSMVASAEQPR 15 0 E7EMN6;Q6NXS1;P41236;E7EUI7 E7EMN6 PPP1R2;PPP1R2P3 Protein phosphatase inhibitor 2-like protein 3;Protein phosphatase inhibitor 2 0 3250680.0 520680.0 1521100.0 1208900.0 False True 682616.5222722923 1294157.8092013604 1083814.6245876371 1.0 1.8958782375987193 1.5877357040521631 19.380715808756133 -10.015684721310055 4.93584201637098 0.9999899976189744 1.7418069708344315 0.8854145681805857 0.1257986625737353 16968226.5809848 34431491.78301285 1179.8174661722908 0.043064230525619265 9.645289751340927e-11 10.015684721310055 0.741816973215457 TSTTSSMVASAEQPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSTTSSMVASAEQPR 15 0 E7EMN6;Q6NXS1;P41236;E7EUI7 E7EMN6 PPP1R2;PPP1R2P3 Protein phosphatase inhibitor 2-like protein 3;Protein phosphatase inhibitor 2 0 2998210.0 857110.0 0.0 2141100.0 False True 829901.5122082935 0.0 1580281.6783768353 1.0 0.0 1.9041797793232687 19.662580610559722 -6.76398842410162 1.597288346848225 0.42204492062040694 1.912587154150911 0.7071220581880544 0.42088055877799463 0.2762555953924804 1.3899276619897505 0.20780999869024386 0.4974873080739402 1.7219144711281911e-07 6.76398842410162 1.490542233530504 TSTTSSMVASAEQPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSTTSSMVASAEQPR 15 0 E7EMN6;Q6NXS1;P41236;E7EUI7 E7EMN6 PPP1R2;PPP1R2P3 Protein phosphatase inhibitor 2-like protein 3;Protein phosphatase inhibitor 2 0 3559880.0 520680.0 1326600.0 1712600.0 False True 713189.4668479245 1267986.4255204438 1308119.1521041554 1.0 1.7779096361651963 1.8341818169099369 19.443925870279024 -11.173381006213127 0.4545571298706857 2.866834416175614e-13 1.834328435379715 0.9997242230718618 0.00632156356791348 3.1895057540100558 0.22259085370196996 3.264323676383714 0.012554836294002645 6.7084006722089225e-12 11.173381006213127 1.8343284353794282 TSTVINWFHNYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSTVINWFHNYR 12 0 A0A2R8YDI1;A0A2R8Y852;P39880-6;P39880-4;P39880-5;P39880-2;P39880;P39880-3 A0A2R8YDI1 CUX1 Homeobox protein cut-like 1 0 18599100.0 6911300.0 5118700.0 6569100.0 False True 8946814.092090337 4833839.845301073 5373591.204657996 1.0 0.5402861617047072 0.6006150512738002 23.09294260792437 -10.30806456037562 5.6636742634031405 1.0000517745304405 0.5704506064895126 0.9854216679568603 0.02462916603218026 1.610340927333669e-05 1.967335580421604e-06 0.023849950892763917 0.007949029156132126 4.919663966074693e-11 10.30806456037562 -0.42960116804092785 TSVETALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSVETALR 8 0 P47755;F8W9N7;A0A0D9SET8;C9JUG7;P47755-2 P47755 CAPZA2 F-actin-capping protein subunit alpha-2 0 5858700.0 1629100.0 1950200.0 2279400.0 False True 2135765.876226843 1659237.7618200588 2043549.5535487314 1.0 0.7768818578332921 0.9568228317042757 21.026322076031743 -9.96856832560371 5.622047827427451 1.0000002116290458 0.8668523448580118 0.4219781152257801 0.07346059496769715 1.9489075850839179e-07 3.5725329907305184e-08 0.0711280281056339 0.023709305075963947 1.0750574531183254e-10 9.96856832560371 -0.13314786677103407 TSVETALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSVETALR 8 0 P47755;F8W9N7;A0A0D9SET8;C9JUG7;P47755-2 P47755 CAPZA2 F-actin-capping protein subunit alpha-2 0 5268800.0 1892300.0 1403000.0 1973500.0 False True 1832229.9722926521 1963225.216548345 1456581.1462690574 1.0 1.0714949794712614 0.7949772508341031 20.805169163950957 -6.838057405563043 1.2912767792072966 1.0380499246602322 0.7862205385051709 0.9210786531240064 0.03292297877426221 0.1710809906919148 0.5549404262396752 0.019998084078253847 0.046053313361677624 1.4519196884257113e-07 6.838057405563043 -0.25182938615506123 TSVETALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSVETALR 8 0 P47755;F8W9N7;A0A0D9SET8;C9JUG7;P47755-2 P47755 CAPZA2 F-actin-capping protein subunit alpha-2 0 5814500.0 1629100.0 2179600.0 2005800.0 False True 2231422.294772135 2083298.065026657 1532071.3507477022 1.0 0.933618916467533 0.6865896044586002 21.089532137554635 -6.946535458310878 0.5956721064002739 1.0028110512992867 0.6048457148182041 0.998900542289727 0.004471298061127475 0.08490760682641378 0.04195593399335959 0.004608883568237801 0.020730944058890206 1.1310050437771664e-07 6.946535458310878 -0.39796533648108257 TSVIK(ub)GIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSVIKGIK 8 1 Q9ULC4;Q9ULC4-3;A0A3B3IRV3 Q9ULC4 MCTS1 Malignant T-cell-amplified sequence 1 1 13414200.0 2349700.0 1208000.0 9856500.0 True False 3041732.9695114763 1140773.7380826569 8062718.136230465 1.0 0.3750407249804946 2.6506988670755653 21.53646207528891 -6.83348599700047 1.3121502926347657 0.6667693351407317 2.716459058167719 0.9126804385755793 0.2836720552188139 0.17655452448932818 0.5932454156118072 0.1696716130645227 0.3904988727870366 1.4672833959073444e-07 6.83348599700047 2.0496897230269875 up TSVLAAANPIESQWNPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSVLAAANPIESQWNPK 17 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 23986300.0 5462500.0 9467000.0 9056800.0 False True 7161390.398925246 8054560.502076972 8119689.214960145 1.0 1.124720208422902 1.133814631328955 22.771808286268282 -13.295054208858788 0.3794547088004642 1.4187545093302721e-05 1.1346415170334938 0.9997867336960821 0.0008915371518097545 13.918253980315884 0.1997477593192286 11.125558006289424 0.0024696728068156924 5.0692742938518776e-14 13.295054208858788 1.1346273294884004 TSVLAAANPIESQWNPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSVLAAANPIESQWNPK 17 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 26496800.0 10699000.0 4437800.0 11360000.0 False True 10359366.101336515 6209836.682821278 8384475.207305049 1.0 0.599441763335318 0.809361801222888 23.30443239016671 -10.03298999543505 4.917891873499641 1.0000050733972063 0.7044017822763612 0.7255639628745656 0.0856994966138586 4.875505857795258e-06 9.585839316094873e-07 0.0829796370709594 0.02765939359525234 9.268511744127033e-11 10.03298999543505 -0.29560329112084516 TSVLAAANPIESQWNPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSVLAAANPIESQWNPK 17 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 54050500.0 8051400.0 37228000.0 8771100.0 False True 12214562.43618467 30584372.536308378 7037488.240490295 1.0 2.503926988469485 0.5761555747295781 23.54209884689543 -6.69853075177617 1.8360093062893128 1.9352102728657294 0.5820255425122999 0.41066181659817036 0.6349972122841345 0.3985818986722753 2.611076104555868 0.2760200223915302 0.7111672976817837 2.002023856100829e-07 6.69853075177617 -1.3531847303534295 TSVLAAANPIESQWNPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSVLAAANPIESQWNPK 17 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 25095700.0 5462500.0 9313200.0 10320000.0 False True 7482133.868511924 8901712.029366061 7882628.54707165 1.0 1.1897290513376593 1.0535267993860926 22.835018347791173 -10.26418020008767 3.5648447459364605 0.9997116497028758 1.121627925397159 0.5153285354367095 0.05560433694421412 10553619.075662348 16427641.998440146 31776.43313941821 0.0203491033047428 5.442767713805797e-11 10.26418020008767 0.1219162756942832 TSVLAAANPIESQWNPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSVLAAANPIESQWNPK 17 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 19620600.0 10699000.0 4235000.0 4686600.0 False True 8896692.54606456 4212185.214418319 5666546.391609916 1.0 0.47345518490257077 0.6369273032950324 23.084837665600986 -10.356080800279457 4.969280339442794 1.0002807749174483 0.5551912440986994 0.9080192304175738 0.06673721287258463 0.00020772616155454913 2.6916932230709068e-05 0.06465813992944498 0.02153934283560074 4.404729061104135e-11 10.356080800279457 -0.4450895308187489 TSVLAAANPIESQWNPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSVLAAANPIESQWNPK 17 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 26504500.0 8051400.0 10715000.0 7738100.0 False True 10422696.01682117 10118700.830758005 6329845.199610911 1.0 0.9708333443120142 0.6073136153443587 23.31322516898788 -6.922855043562131 0.8032751858649547 1.0072259043101355 0.544663718796457 0.9949377561026311 0.012709906725973313 0.09652105916433008 0.09712438937563653 0.011119796075784064 0.034274817581545394 1.194386693801998e-07 6.922855043562131 -0.46256218551367845 TSVLAAANPIESQWNPKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSVLAAANPIESQWNPKK 18 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 21346300.0 7236000.0 7084200.0 7026100.0 True False 9486466.073523685 6027264.973995321 6299106.571110257 1.0 0.635354085207468 0.6640098138010306 23.1774393196142 -9.976239548548945 5.255882957860205 1.0000013850374743 0.6496819495042966 0.9950067275139359 0.011698652216262014 1.9984889940885744e-07 3.892262523678568e-08 0.011327218387427314 0.003775723766364047 1.0562347495762513e-10 9.976239548548945 -0.3503194355331777 TSVLAAANPIESQWNPKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSVLAAANPIESQWNPKK 18 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 35112000.0 10038000.0 14864000.0 10210000.0 True False 8347041.758799517 14783924.681726988 12344863.794293791 1.0 1.7711573883216363 1.478950764955709 22.992833557797777 -10.117304422839375 4.590861763841845 0.9999478985554819 1.6250540766536599 0.8591727533555278 0.11929285451524294 83837968.72810397 50325623.84300785 53025.23712239403 0.04365671262668359 7.633005532442367e-11 10.117304422839375 0.6251061780981779 TSVLHVMVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSVLHVMVK 9 0 H3BQG3;A8MT40;Q8NCN5 H3BQG3 PDPR Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial 0 4887400.0 1320200.0 1810400.0 1756800.0 False True 1709024.9250325821 1709649.6485304977 1437080.4262902348 1.0 1.000365543819031 0.8408773946130933 20.704742007273673 -6.906382134737993 0.9200275205663027 1.0055206479319088 0.8217854130417708 0.9894829840231321 0.007701426627592506 0.10685907374594154 0.15210729344837898 0.0061945776019961775 0.016699969179818835 1.2405602610342783e-07 6.906382134737993 -0.183735234890138 TSVPENHAQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSVPENHAQSR 11 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 7416300.0 1871700.0 2820200.0 2724400.0 False True 2453816.8255685847 2399437.153053498 2442505.2222901452 1.0 0.9778387400606049 0.9953902006211004 21.226596126920306 -10.262007854373328 5.213307338426658 1.0000019021975275 0.9866144703408544 0.4367790796986044 0.007165353768974997 1.5844184609373855e-07 2.2424566743673796e-08 0.006938809943797507 0.002312607984742454 5.470060700012071e-11 10.262007854373328 -0.013387431856673127 TSVPENHAQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSVPENHAQSR 11 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 9718000.0 2919200.0 2953300.0 3845500.0 False True 2826531.593889292 4132568.0912560388 2838248.1874728478 1.0 1.4620632934690279 1.004145219394995 21.43060139230111 -10.64899056723845 3.107341908697634 0.9810892239110334 1.2331042565678885 0.2567886809719102 0.18694427154340185 138287236.21643472 160141163.67014566 21147684.787376404 0.06841459370555021 2.243930660835338e-11 10.64899056723845 0.2520150326568551 TSVPENHAQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSVPENHAQSR 11 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 10318500.0 1871700.0 4308100.0 4138700.0 False True 2563718.070790623 4117753.8970184084 3161224.2992020724 1.0 1.6061648681005465 1.233062377341353 21.289806188443197 -10.11720291368515 4.329375623240394 0.99994488749624 1.4196136225284055 0.6277659163661775 0.15231845420910142 22451670.934894472 26233366.004927963 10779.110837957916 0.05214265698795117 7.634789829793163e-11 10.11720291368515 0.4196687350321655 TSVPENHAQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSVPENHAQSR 11 0 Q9UQ35 Q9UQ35 SRRM2 Serine/arginine repetitive matrix protein 2 0 5041450.0 2919200.0 1504500.0 617750.0 False True 2427444.1424873015 1496394.9598801325 746918.6688467182 1.0 0.6164487716478776 0.30769757201555276 21.211006667735386 -7.742952033489734 0.246248430697287 1.157133100778298 1.7508812849928564e-09 0.9997665604047427 0.004326636811411362 0.1262214587833126 0.034174576730541466 0.04450274600029941 0.08265563176964921 1.807373733942962e-08 7.742952033489734 -1.1571330990274167 down TSVVGLFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSVVGLFLR 9 0 F5H0F9;Q9UJX4-3;Q9UJX4;F5GY68;F5GZ05;F5H3S5 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 0 636110.0 636110.0 0.0 0.0 False True 833946.3700980032 0.0 0.0 1.0 0.0 0.0 19.669595083428778 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 TSVVGLFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSVVGLFLR 9 0 F5H0F9;Q9UJX4-3;Q9UJX4;F5GY68;F5GZ05;F5H3S5 F5H0F9 ANAPC5 Anaphase-promoting complex subunit 5 0 3349750.0 636110.0 925040.0 1788600.0 False True 871297.0572263842 884168.6741017881 1366169.5173732897 1.0 1.0147729373910412 1.5679721468614183 19.73280514495167 -6.912627337390845 0.8776563760745558 0.984261632929481 1.6436308856453086 0.9918756010587502 0.023825631495514667 0.10270659717968927 0.12953499986807426 0.019763289639412315 0.055601433808284625 1.2228485209629103e-07 6.912627337390845 0.6593692527158276 TSYAQHQQVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSYAQHQQVR 10 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6;H0Y8L7;D6RAS7 P61247 RPS3A 40S ribosomal protein S3a 0 136554100.0 26127200.0 63104000.0 47322900.0 False True 34253012.21616468 53689129.17746537 42426380.26131049 1.0 1.5674279633756825 1.2386174971580641 25.02972752872955 -10.201940200442555 4.9457234820221165 0.9999544668926795 1.4030227302674656 0.6670127606323357 0.1342363107220874 6.740580889542136e-05 1.0876484261570265e-05 0.12998839743322668 0.04332458298994475 6.281448443647376e-11 10.201940200442555 0.4030682633747861 TSYAQHQQVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSYAQHQQVR 10 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6;H0Y8L7;D6RAS7 P61247 RPS3A 40S ribosomal protein S3a 0 88493600.0 30374400.0 33294700.0 24824500.0 False True 29410181.29810593 46589447.33956679 18322218.730963375 1.0 1.5841264923643037 0.6229889760027886 24.809812341910575 -6.742206828509406 1.6785413954795991 1.346671674110098 0.6221461821557128 0.6147678637054987 0.2454180803887509 0.3138749405473604 1.7372207976112986 0.11562435548884978 0.2830556327957202 1.8104776649522064e-07 6.742206828509406 -0.7245254919543851 TSYAQHQQVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSYAQHQQVR 10 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6;H0Y8L7;D6RAS7 P61247 RPS3A 40S ribosomal protein S3a 0 19799540.0 10639600.0 1338000.0 7821940.0 False True 16141051.058950055 1099223.4461582862 6275930.130521916 1.0 0.06810110705577488 0.38881793432169176 23.94423119004925 -10.470319094784445 6.076749930855766 1.000466251573626 0.2284595236849451 0.8852732557004315 0.13093209645430495 0.000827529149698124 7.213183628573426e-05 0.1268456312349702 0.04225815242096214 3.3859528424295916e-11 10.470319094784445 -0.7720067278886809 TSYAQHQQVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSYAQHQQVR 10 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6;H0Y8L7;D6RAS7 P61247 RPS3A 40S ribosomal protein S3a 0 104056600.0 26127200.0 41724800.0 36204600.0 False True 35787131.90103151 39881260.37053775 27653819.13714247 1.0 1.1144022516481191 0.7727308020552882 25.09293759025244 -6.816411127727129 1.3872356450413126 1.0618965586302962 0.7658255289352834 0.8759380022018235 0.050016208858560944 0.19819526633255477 0.7503844522706221 0.028338599815749172 0.06538960209249253 1.5261206620389178e-07 6.816411127727129 -0.29607102969501276 TSYAQHQQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSYAQHQQVR 10 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6;H0Y8L7;D6RAS7 P61247 RPS3A 40S ribosomal protein S3a 0 67030940.0 30374400.0 24991700.0 11664840.0 False True 25257659.414074484 24857064.75163592 14103904.11187366 1.0 0.9841396759742774 0.558401072746054 24.59021761734485 -6.91477759580768 0.8625573208468794 1.011274718881763 0.49736371723296086 0.9926032180039703 0.017591018952993878 0.1013430841872941 0.12225445032596481 0.01475125928513493 0.04220354340455791 1.216808974565107e-07 6.91477759580768 -0.5139110016488022 TSYEEFTHK(ub)DGVWNLQNEVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSYEEFTHKDGVWNLQNEVTK 21 1 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 29220000.0 6608500.0 14831200.0 7780300.0 True False 8663807.496805033 12618442.771564798 6975269.189907507 1.0 1.456454656479628 0.8051043600033575 23.046569757043024 -6.718330568683462 1.7653255809899864 1.2781935917044973 0.8062133470200629 0.5046416659665725 0.19211788058689447 0.3585632835386306 2.182886398843076 0.08644221705048678 0.21742927077332475 1.912799419541021e-07 6.718330568683462 -0.47198024468443445 TSYEEFTHK(ub)DGVWNLQNEVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TSYEEFTHKDGVWNLQNEVTK 21 1 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 34622800.0 9572100.0 11354700.0 13696000.0 True False 9268238.925002635 15888690.923978275 10108606.72880722 1.0 1.7143160693792492 1.0906717889563196 23.1438638050972 -10.263923794837636 4.589902546241577 0.9998316390855773 1.4024939291697414 0.357066746408072 0.25460171134690546 0.0004388213514383877 7.037391516093087e-05 0.246619366933317 0.08217234899593127 5.445982044910254e-11 10.263923794837636 0.4026622900841641 TSYEEFTHK(ub)DGVWNLQNEVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSYEEFTHKDGVWNLQNEVTK 21 1 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 76030500.0 26443600.0 22868700.0 26718200.0 True False 40116874.48611337 18787601.811031364 21437336.058996942 1.0 0.46832167390145946 0.5343720400356107 25.25770587387462 -10.373448850589101 5.848587784731921 1.0001079839380875 0.5013468569690692 0.987012154276584 0.02696494905878214 3.797559180843377e-05 4.068239693615712e-06 0.026114297572657517 0.008702899886332494 4.232053501603066e-11 10.373448850589101 -0.4987611269690183 TSYEEFTHK(ub)DGVWNLQNEVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSYEEFTHKDGVWNLQNEVTK 21 1 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 27190800.0 6608500.0 13385300.0 7197000.0 True False 9051841.037997447 12793893.186732115 5497216.826867696 1.0 1.4134023269991636 0.6073037301242592 23.109779818565915 -6.76732847172259 1.584936851441567 1.2379275573468767 0.6032473117375697 0.7201438315220781 0.1741116114832093 0.27077132934012205 1.3419905203359226 0.08661564441755676 0.20666912022910103 1.7087224611861764e-07 6.76732847172259 -0.6346802456093069 TSYEEFTHK(ub)DGVWNLQNEVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TSYEEFTHKDGVWNLQNEVTK 21 1 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 31434500.0 9572100.0 15173500.0 6688900.0 True False 7959625.265929948 15091757.343796063 8087518.064020749 1.0 1.8960386751364038 1.0160676908545216 22.924269080531477 -6.641983503761669 2.037289921699491 1.5850796498135693 1.0197406163827183 0.16222712748995705 0.38320002735031444 0.5284084208053917 4.194065909656144 0.15304384668111193 0.42433768504562813 2.2804286901415564e-07 6.641983503761669 -0.565339033430851 TSYEEFTHK(ub)DGVWNLQNEVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSYEEFTHKDGVWNLQNEVTK 21 1 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 56175600.0 26443600.0 19229000.0 10503000.0 True False 34231761.48128431 18158889.2463505 8591561.769880654 1.0 0.5304690281941405 0.2509821697191352 25.02883219596707 -8.659582554612603 0.22549854163554028 1.2959061063669055 9.68428254995831e-12 0.9994945175659216 0.006948320132794747 0.2396937113072189 0.0637038835814821 0.17145781903472293 0.12085239562510197 2.189865519110627e-09 8.659582554612603 -1.2959061063572213 down TSYGWIEIVGCADR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TSYGWIEIVGCADR 14 0 P41250 P41250 GARS Glycine--tRNA ligase 0 26288300.0 6945700.0 10760000.0 8582600.0 False True 10537134.69868693 8839793.931736285 6886245.348112792 1.0 0.8389181864437819 0.6535216209175831 23.32897928090411 -6.969285685644637 0.27472091198835424 1.043528889555313 0.4433019441840667 0.9999762572362975 0.0006897744639042652 0.07653523316236997 0.009857260823324637 0.0035320551887431015 0.01713347519726106 1.0732831577699285e-07 6.969285685644637 -0.6002269453712463 TSYGWIEIVGCADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TSYGWIEIVGCADR 14 0 P41250 P41250 GARS Glycine--tRNA ligase 0 20615700.0 6945700.0 5994700.0 7675300.0 False True 8991345.570215723 5661089.675235186 6278474.155228502 1.0 0.6296154041712985 0.698279707547473 23.10010560299656 -10.751588103160733 6.956837833236933 1.0062841387431687 0.663947555859466 0.9696387827535046 0.028032084469215325 0.0027554026669991266 9.838870277364916e-05 0.02737229420389529 0.009047316359062542 1.7717885747416525e-11 10.751588103160733 -0.3423365828837027 TSYLTELIDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TSYLTELIDR 10 0 B4DR80;Q9Y6E0-2;Q9Y6E0;H0Y630;Q5JV98;Q5JV99;Q8NBY1;B4E0Y9;Q9P289;Q9P289-2;Q9P289-3 B4DR80;Q8NBY1 STK24;STK26 Serine/threonine-protein kinase 24;Serine/threonine-protein kinase 24 36 kDa subunit;Serine/threonine-protein kinase 24 12 kDa subunit;Serine/threonine-protein kinase 26 0 5295600.0 1382800.0 1850300.0 2062500.0 False True 1812864.1910542503 1574242.4524129098 1849092.2848970157 1.0 0.8683730751487938 1.019983898419714 20.789839420367997 -6.677129908981997 1.9118684698879502 0.9165056353218917 1.0193976127639062 0.3111262061257368 0.05582177426903426 0.44493490169680155 3.141768701842269 0.02344878488264481 0.062077823659140136 2.1031492380258876e-07 6.677129908981997 0.1028919774420145 TSYLTELIDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TSYLTELIDR 10 0 B4DR80;Q9Y6E0-2;Q9Y6E0;H0Y630;Q5JV98;Q5JV99;Q8NBY1;B4E0Y9;Q9P289;Q9P289-2;Q9P289-3 B4DR80;Q8NBY1 STK24;STK26 Serine/threonine-protein kinase 24;Serine/threonine-protein kinase 24 36 kDa subunit;Serine/threonine-protein kinase 24 12 kDa subunit;Serine/threonine-protein kinase 26 0 5864900.0 1382800.0 2232100.0 2250000.0 False True 1894058.5287649063 2133478.441432374 1718596.3402045732 1.0 1.1264057625629926 0.9073617916787662 20.85304948189089 -6.750227058629687 1.648757220257179 1.0743107016581463 0.9069138864222656 0.6499396927263896 0.05311785114936254 0.29970496017743975 1.602985130080129 0.025447648626125658 0.061771284042489494 1.7773499297659502e-07 6.750227058629687 -0.1673968152358808 TTAAFQQGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTAAFQQGK 9 0 P09234;A0A0A0MRR7;Q5TAL2 P09234 SNRPC U1 small nuclear ribonucleoprotein C 0 5236700.0 1104000.0 2382300.0 1750400.0 False True 1447354.6911512073 2026870.1261326673 1569285.3990224164 1.0 1.400396280555474 1.0842438336757847 20.464987083771128 -9.957265055662795 5.401955539262076 0.999999435607088 1.2423200571163826 0.4392397223591772 0.12906869596724435 8.773120041733127e-07 1.6943425659450292e-07 0.12497051985828302 0.04165674249943794 1.1034049917096787e-10 9.957265055662795 0.24232062150929456 TTAAFQQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTAAFQQGK 9 0 P09234;A0A0A0MRR7;Q5TAL2 P09234 SNRPC U1 small nuclear ribonucleoprotein C 0 3641000.0 1289600.0 1079000.0 1272400.0 False True 1248662.3538913499 1509850.3269106655 939120.2688182172 1.0 1.209174219279812 0.7521010510900156 20.251951985244595 -6.782259513608018 1.5268316544791591 1.1180939252954212 0.7482061491330902 0.7753558628636004 0.08854755798520088 0.2470933761221025 1.1378545303752114 0.04566849278609786 0.10756740502499207 1.6509749597526684e-07 6.782259513608018 -0.36988777616233093 TTAAFQQGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTAAFQQGK 9 0 P09234;A0A0A0MRR7;Q5TAL2 P09234 SNRPC U1 small nuclear ribonucleoprotein C 0 4112200.0 1104000.0 1792400.0 1215800.0 False True 1512178.6344781988 1713205.8413258286 928653.0801869868 1.0 1.1329387958962913 0.6141159906729097 20.52819714529402 -6.838723997046388 1.288275449255064 1.0707366726097243 0.597474338912682 0.9222456007262579 0.06135685119433164 0.17029207220864548 0.5495496086965085 0.03735335118118704 0.08602927365711396 1.4496928700797067e-07 6.838723997046388 -0.4732623336970423 TTAAFQQGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTAAFQQGK 9 0 P09234;A0A0A0MRR7;Q5TAL2 P09234 SNRPC U1 small nuclear ribonucleoprotein C 0 1696670.0 1289600.0 0.0 407070.0 False True 1072359.538966711 0.0 492186.4549209765 1.0 0.0 0.45897521963131 20.03235726067887 -10.660873984001096 5.714126649864407 1.0088914096768984 0.22948760981565788 0.7898134154394965 0.18737584877975855 0.021178629122746137 0.001256923231267427 0.18103445019641226 0.060475295150456965 2.18336335023883e-11 10.660873984001096 -0.7794037998612405 TTAGLCLLTWGGHWLYGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTAGLCLLTWGGHWLYGK 18 0 A0A3B3ISZ0;Q53H12;A0A3B3ITX7;E9PG39;F8WDD1;A0A3B3IRM6;A0A3B3IS09;Q53H12-2 A0A3B3ISZ0 AGK Acylglycerol kinase, mitochondrial 0 15757400.0 4623000.0 6471900.0 4662500.0 False True 7013428.986571502 5316938.879814503 3740954.831353653 1.0 0.7581083219056982 0.5333988322283434 22.741688544571826 -6.972010978575972 0.2045274843408675 1.1261822750987647 0.15908991110451087 0.999994109944774 0.00046237479882754674 0.07565541201300667 0.006641145918080611 0.0070308634501428735 0.02358941461747203 1.0665691589753077e-07 6.972010978575972 -0.9670923639942538 TTAGLCLLTWGGHWLYGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTAGLCLLTWGGHWLYGK 18 0 A0A3B3ISZ0;Q53H12;A0A3B3ITX7;E9PG39;F8WDD1;A0A3B3IRM6;A0A3B3IS09;Q53H12-2 A0A3B3ISZ0 AGK Acylglycerol kinase, mitochondrial 0 13195900.0 4623000.0 3909600.0 4663300.0 False True 5984564.632953812 3692027.3231853917 3814627.2494986607 1.0 0.6169249644084989 0.6374109870070646 22.512814866664275 -10.105867751078005 5.1057471843824125 1.0000101308373874 0.627167975707359 0.9977407304477623 0.008363383706967306 9.659547715352809e-07 1.6915433021598095e-07 0.008098031735836743 0.002699270484198154 7.836682446979794e-11 10.105867751078005 -0.3728421551300284 TTAQVLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTAQVLIR 8 0 P15121;C9JRZ8;C9JRZ8-2 P15121 AKR1B1;AKR1B15 Aldose reductase;Aldo-keto reductase family 1 member B15 0 110276000.0 41828000.0 34123000.0 34325000.0 False True 54836913.06292814 29031981.41041223 30773378.268649712 1.0 0.5294240647188976 0.5611799889854431 25.70864402391085 -9.949944867894065 5.3060765877741884 1.0000012191300929 0.5453020268497831 0.9963551555321905 0.01296430180227488 1.869756252731254e-07 3.697934267871642e-08 0.012552664906176273 0.004184210413411812 1.1221608995077649e-10 9.949944867894065 -0.45469919228030975 TTAQVLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTAQVLIR 8 0 P15121;C9JRZ8;C9JRZ8-2 P15121 AKR1B1;AKR1B15 Aldose reductase;Aldo-keto reductase family 1 member B15 0 82299000.0 24273000.0 10498000.0 47528000.0 False True 23502466.901368424 14689906.146346787 35078990.99056289 1.0 0.6250367762667276 1.49256633943054 24.486308859281905 -6.789235996638346 1.499343987017978 0.7902257882749022 1.501605217946615 0.798855650499812 0.1593267413171533 0.23649010291157088 1.0502767480490913 0.08364549270586275 0.19594750576346243 1.624665668707979e-07 6.789235996638346 0.7113794296717129 TTAQVLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTAQVLIR 8 0 P15121;C9JRZ8;C9JRZ8-2 P15121 AKR1B1;AKR1B15 Aldose reductase;Aldo-keto reductase family 1 member B15 0 114187000.0 31492000.0 50417000.0 32278000.0 False True 47775666.37359067 41419692.44018111 25898239.152050007 1.0 0.8669621082057161 0.5420801240014933 25.50977266022264 -6.9559630304719935 0.48902695237420285 1.0071728986155566 0.38811574683982036 0.9995899135805547 0.0038949119412486155 0.08117610968153754 0.026709956088712416 0.004667850401515998 0.026795315629575128 1.1067179898725792e-07 6.9559630304719935 -0.6190571517757362 TTAQVLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTAQVLIR 8 0 P15121;C9JRZ8;C9JRZ8-2 P15121 AKR1B1;AKR1B15 Aldose reductase;Aldo-keto reductase family 1 member B15 0 85360000.0 41828000.0 17325000.0 26207000.0 False True 57292941.95919753 16559524.213886412 20017446.35010723 1.0 0.28903253433345516 0.3493876499545635 25.77185408543374 -10.427707423039793 5.388588616850301 1.000561259678754 0.31921009214400275 0.9941398232821022 0.0246398727730893 0.00016627068781984187 1.7658696656476958e-05 0.023875952607206968 0.007952484741900369 3.735016949300155e-11 10.427707423039793 -0.6813511675347513 TTAQVLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTAQVLIR 8 0 P15121;C9JRZ8;C9JRZ8-2 P15121 AKR1B1;AKR1B15 Aldose reductase;Aldo-keto reductase family 1 member B15 0 53270000.0 24273000.0 18652000.0 10345000.0 False True 20184074.97622438 18551517.973867863 12508091.670124322 1.0 0.9191165805577134 0.6197010110623399 24.26671413471618 -6.946657104602565 0.5944221931129889 1.0034181902653727 0.5202186056016873 0.9989120629176077 0.005395427734497125 0.0848567299348748 0.04173813859458706 0.005568454748427467 0.025117402984510935 1.1306882925669108e-07 6.946657104602565 -0.4831995846636854 TTAQVLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTAQVLIR 8 0 P15121;C9JRZ8;C9JRZ8-2 P15121 AKR1B1;AKR1B15 Aldose reductase;Aldo-keto reductase family 1 member B15 0 98679000.0 31492000.0 39945000.0 27242000.0 False True 40767014.80012576 37722025.63552294 22284235.526524685 1.0 0.925307526696965 0.5466241674986696 25.28089898231509 -6.939497015299693 0.6642362048440187 1.0042897257678411 0.44600213665333877 0.998097131276524 0.00865783635836275 0.08799716157115635 0.05566242313159697 0.008395900983620808 0.032665494941364955 1.1494841432528479e-07 6.939497015299693 -0.5582875891145024 TTAVK(ub)QWEQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTAVKQWEQR 10 1 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;A0A0J9YXA0;A0A0J9YXE6;A0A0J9YYC6;B9TX12;A0A087WU12 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 4027300.0 1078500.0 1172500.0 1776300.0 True False 1413923.9442088576 997567.5703692037 1592505.5154727593 1.0 0.7055312801335856 1.1263021055660987 20.431273088153414 -6.718570209238507 1.7643649904603238 0.8205749886387436 1.1255976456900336 0.5057731560700902 0.12393602571169693 0.3581187679000435 2.1779191230550192 0.05579033259909019 0.14029570237473885 1.9117442417978843e-07 6.718570209238507 0.30502265705129006 TTAVK(ub)QWEQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTAVKQWEQR 10 1 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;A0A0J9YXA0;A0A0J9YXE6;A0A0J9YYC6;B9TX12;A0A087WU12 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 10177500.0 1251800.0 2676300.0 6249400.0 True False 1212062.2942006781 3744960.5467201252 4612494.662018677 1.0 3.089742635043213 3.80549307084954 20.20903241766051 -9.499295300344137 0.3183620136445396 1.808527011770626e-21 4.043263050780268 0.9986034196917285 0.044480405564453346 0.8707881026357622 0.12852259000850386 1.1680112954070956 0.23376331350204146 3.167413034967921e-10 9.499295300344137 4.043263050780268 TTAVK(ub)QWEQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTAVKQWEQR 10 1 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;A0A0J9YXA0;A0A0J9YXE6;A0A0J9YYC6;B9TX12;A0A087WU12 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 4941300.0 1078500.0 1152300.0 2710500.0 True False 1477250.5953666118 1101387.575853467 2070335.724499776 1.0 0.745565836499212 1.4014790252874985 20.494483149676306 -6.801518240611881 1.4496638771117485 0.8598846848212555 1.4108801600759835 0.8365667764908163 0.10915624462267594 0.21860372798530148 0.9068004800213901 0.059231267913933634 0.137627270904065 1.579362272244038e-07 6.801518240611881 0.550995475254728 TTAVK(ub)QWEQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTAVKQWEQR 10 1 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;A0A0J9YXA0;A0A0J9YXE6;A0A0J9YYC6;B9TX12;A0A087WU12 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 1390760.0 1251800.0 0.0 138960.0 True False 1040927.1641427815 0.0 168015.89352155378 1.0 0.0 0.16140984624982602 19.989437693094786 -10.197372805502845 4.259491252633208 1.0003493135758807 0.08070492308538613 0.9774012540528255 0.06589529396300789 345794477.6210841 689112877.1616205 1634628.9259908875 0.02298675731967791 6.347857873785369e-11 10.197372805502845 -0.9196443904904946 TTCSCSLAVQLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTCSCSLAVQLSK 13 0 O43681 O43681 ASNA1 ATPase ASNA1 0 26180100.0 7327100.0 6736000.0 12117000.0 False True 9605899.055737326 5731015.056722346 10863249.074471328 1.0 0.5966141246611764 1.1308935281787105 23.195489217317327 -6.704741089773901 1.8138337918430847 0.7506876491756337 1.1294602287425197 0.4401529567611252 0.17013105215041838 0.38574558143088145 2.470426507503417 0.0747354722857266 0.1910922277883663 1.9735989718084954e-07 6.704741089773901 0.37877257956688604 TTCSCSLAVQLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTCSCSLAVQLSK 13 0 O43681 O43681 ASNA1 ATPase ASNA1 0 31602900.0 4385900.0 16466000.0 10751000.0 False True 6653730.952239651 13527513.65055481 8626060.137669312 1.0 2.0330719332739835 1.29642454730842 22.665732100450704 -10.032156118508617 4.39872312958338 0.9999660072423789 1.6647482395686994 0.5205584450547515 0.30073503631175974 209575162.40975165 457151087.12936926 114970.37921704624 0.11005774394238246 9.286325055338722e-11 10.032156118508617 0.6647822323263205 TTCSCSLAVQLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTCSCSLAVQLSK 13 0 O43681 O43681 ASNA1 ATPase ASNA1 0 26237900.0 7327100.0 5681800.0 13229000.0 False True 10036126.877432253 5430759.28879998 10104582.659807244 1.0 0.5411210275760724 1.0068209363244425 23.25869927884022 -10.926288586771438 11.442815041357967 1.0324114252981706 0.7739709819506209 0.23901741504634855 0.1901211916156991 0.10403173942693429 0.0006701422413661631 0.12181996428832653 0.06136135074072597 1.1849810717865452e-11 10.926288586771438 -0.2584404433475498 TTCSCSLAVQLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTCSCSLAVQLSK 13 0 O43681 O43681 ASNA1 ATPase ASNA1 0 26744400.0 4385900.0 12945000.0 9413500.0 False True 5677634.009014079 12224599.370430475 7700339.590666612 1.0 2.1531150741703544 1.3562585362919113 22.436858422543153 -10.16196703986851 4.811230097837095 0.9999298871927506 1.7546868052346807 0.5446156238674194 0.3253153193460452 0.000244680769564645 4.26193920181357e-05 0.3150142731026801 0.10499506783937798 6.887045625657565e-11 10.16196703986851 0.7547569180419301 TTCSCSLAVQLSK(ub)GR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTCSCSLAVQLSKGR 15 1 O43681 O43681 ASNA1 ATPase ASNA1 1 19154600.0 4373900.0 5913400.0 8867300.0 True False 5734225.256907857 5031143.770252659 7949796.857147786 1.0 0.8773885825625326 1.386376799127466 22.45116714823829 -6.843094493358632 1.267974919963353 0.9347773846958529 1.4041667579033663 0.9296402695917337 0.05753219146846728 0.1652157555362198 0.5146451286485503 0.035559409151761125 0.08200145949548339 1.435177134975727e-07 6.843094493358632 0.4693893732075134 TTCSCSLAVQLSK(ub)GR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTCSCSLAVQLSKGR 15 1 O43681 O43681 ASNA1 ATPase ASNA1 1 11237000.0 3339800.0 4841800.0 3055400.0 True False 3233779.8771140953 6775155.9896534365 2255099.0799647737 1.0 2.095119719682266 0.6973570142867237 21.624790047454205 -6.697722225146982 1.839091281907102 1.681533893448789 0.7016986919168227 0.40676978140162556 0.4624580416607262 0.4002577375527013 2.63033623285933 0.20073709677519558 0.5176803432418041 2.005754498237071e-07 6.697722225146982 -0.9798352015319662 TTCSCSLAVQLSK(ub)GR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTCSCSLAVQLSKGR 15 1 O43681 O43681 ASNA1 ATPase ASNA1 1 41167600.0 9816600.0 15084000.0 16267000.0 True False 14892499.889590688 12392142.348170081 13051820.31992063 1.0 0.832106257515015 0.8764022438599025 23.828082612597232 -10.125399413007242 4.963502935346589 1.0000066452778658 0.8542542506869739 0.9352100797648422 0.01808376070139018 1.3298838814175072e-06 2.343350080730046e-07 0.01751032432812872 0.005836508669200388 7.492048618379365e-11 10.125399413007242 -0.14575239459089184 TTCSCSLAVQLSK(ub)GR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTCSCSLAVQLSKGR 15 1 O43681 O43681 ASNA1 ATPase ASNA1 1 17557300.0 4373900.0 3764300.0 9419100.0 True False 5991049.030203083 3597980.7791245375 7194502.572453734 1.0 0.6005593946879407 1.2008752617752918 22.514377209761182 -6.727317484611421 1.7327392691864179 0.7589046272065653 1.2003637265178762 0.5468760739434148 0.16795420857703688 0.3413055903290115 2.006224424588681 0.07684803970830939 0.19129484094783497 1.8736243217202137e-07 6.727317484611421 0.4414590993113109 TTCSCSLAVQLSK(ub)GR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTCSCSLAVQLSKGR 15 1 O43681 O43681 ASNA1 ATPase ASNA1 1 11821700.0 3339800.0 2849800.0 5632100.0 True False 2777191.6782266027 2834447.561758992 6809746.070111852 1.0 1.0206164680606238 2.452025952511952 21.40519532288848 -6.910035981475204 0.8954902943252349 0.9557311528720264 2.6371536884398443 0.9909351271833741 0.06471249364654803 0.10439421542383805 0.13863843359944264 0.05299041169324384 0.14631389950925386 1.2301668467645257e-07 6.910035981475204 1.681422535567818 up TTCSCSLAVQLSK(ub)GR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTCSCSLAVQLSKGR 15 1 O43681 O43681 ASNA1 ATPase ASNA1 1 42755500.0 9816600.0 23493000.0 9445900.0 True False 12707782.214115152 22185593.89799325 7726843.123118693 1.0 1.74582736186261 0.6080402538324989 23.59920893468968 -6.729899589368783 1.7240309193859666 1.448895328981046 0.6087825486388138 0.5586289179277233 0.3135294495520932 0.336415486298558 1.9589792929431153 0.14413197656582874 0.3576350556951559 1.8625177084723801e-07 6.729899589368783 -0.8401127803422322 TTDFSDFLSIVGCTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTDFSDFLSIVGCTK 15 0 Q9UHD1;E9PPQ5;E9PIZ4;E9PSD5 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 2951760.0 1033200.0 1391600.0 526960.0 False True 1354535.205523031 1183978.704414315 472435.2341572515 1.0 0.874084851827193 0.34878032865511865 20.369366460223596 -6.943908870013084 0.622135829856007 1.0057417553961838 0.1891915478467371 0.9986323697995847 0.010430019360474526 0.08602775772206035 0.04682270466026624 0.010483449082788357 0.044492762964733326 1.137866024379256e-07 6.943908870013084 -0.8165502075494467 down TTDFSDFLSIVGCTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTDFSDFLSIVGCTK 15 0 Q9UHD1;E9PPQ5;E9PIZ4;E9PSD5 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 5661350.0 1033200.0 876250.0 3751900.0 False True 1415201.9611801396 837534.377628742 2865778.4928060183 1.0 0.5918126179886866 2.0249961287618907 20.432576521746487 -6.8305936769654325 1.3252664927971856 0.7819825927177843 2.0640292632062143 0.9070575738304829 0.18379874754180656 0.1800775887681589 0.6183459568119588 0.10888635401648886 0.2505729732370596 1.4770878405833974e-07 6.8305936769654325 1.28204667048843 up TTDGVYEGVAIGGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTDGVYEGVAIGGDR 15 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 34256600.0 4180600.0 16610000.0 13466000.0 False True 5480807.084987991 14131852.745272912 12072667.494993055 1.0 2.578425499408702 2.202717101293396 22.385956924512605 -10.066197642568568 5.199137345340547 0.9999805811296947 2.390571300353993 0.9480928235785431 0.15338231125376267 3.452555998405225e-05 6.2010006345627475e-06 0.14851384959224534 0.049503928089240326 8.58622682984982e-11 10.066197642568568 1.390590719224298 TTDGYLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTDGYLLR 8 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6;H0Y8L7;D6RAS7;D6RED7 P61247 RPS3A 40S ribosomal protein S3a 0 34501200.0 4319200.0 17767000.0 12415000.0 False True 5662513.027192305 15116232.855223555 11130414.893089188 1.0 2.6695272545304456 1.9656316620622563 22.433011033554855 -10.542428768982445 5.952539799413085 0.997510765451162 2.3175794582963483 0.8236863308361047 0.2873641722901867 0.009499793616533955 0.0007302464861945621 0.2784388506586666 0.09274638779804754 2.867947724828337e-11 10.542428768982445 1.3200686928451861 TTDGYLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTDGYLLR 8 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6;H0Y8L7;D6RAS7;D6RED7 P61247 RPS3A 40S ribosomal protein S3a 0 22855900.0 9749300.0 5006400.0 8100200.0 False True 9439813.807997022 7005481.628031096 5978514.619208835 1.0 0.7421207420528083 0.6333297182349172 23.170326973304462 -13.999999999999998 0.11812493219708194 2.2309958169969617 0.4552232774903269 0.999702189251095 0.00265349141200527 11.971331734202048 0.10552805641884222 3.468384936314503 0.15803882633928987 1.0000000000000041e-14 13.999999999999998 -1.7757725395066348 TTDGYLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTDGYLLR 8 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6;H0Y8L7;D6RAS7;D6RED7 P61247 RPS3A 40S ribosomal protein S3a 0 23036200.0 4319200.0 8124000.0 10593000.0 False True 5916124.961991166 7765054.817524575 8091151.569683135 1.0 1.312523800192199 1.3676437907694108 22.496221095077747 -12.539005395777819 0.2677630927587734 5.468918912338659e-09 1.3874399499723864 0.9994693026976448 0.0037294021060446884 6.892095158423592 0.15686085754931683 3.7539395607005748 0.02314380170367709 2.89064396809498e-13 12.539005395777819 1.3874399445034675 TTDGYLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTDGYLLR 8 0 P61247;D6RG13;D6RAT0;H0Y9Y4;D6RB09;E9PFI5;D6R9B6;H0Y8L7;D6RAS7;D6RED7 P61247 RPS3A 40S ribosomal protein S3a 0 18754500.0 9749300.0 5838800.0 3166400.0 False True 8106974.917220979 5807345.225488946 3828479.60022056 1.0 0.7163393602159642 0.47224515177517523 22.95073224873874 -7.015614146391019 0.1796668271608303 1.1923693402982056 5.19831604313727e-11 0.9999969700180754 0.00037534593135519475 0.07225666423346416 0.005617622275805627 0.009512776204499309 0.02673235680703722 9.646857284165791e-08 7.015614146391019 -1.1923693402462225 down TTEAKPESK(ub)QEPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTEAKPESKQEPVK 14 2 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 5966600.0 1556200.0 2278000.0 2132400.0 True False 1506799.2828208113 3187617.2796130637 1573860.469371238 1.0 2.115488981150607 1.0445057197166199 20.523055821054275 -6.636663058388527 2.0565937269908052 1.7313054588161974 1.0489318688296165 0.14191984511782652 0.47768476168400353 0.5418242404936044 4.37572289555682 0.18942424332765845 0.5289453129965002 2.3085375423412697e-07 6.636663058388527 -0.6823735899865808 TTESHMDWEK(ub)VAFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTESHMDWEKVAFK 14 1 P17480;E9PKP7;P17480-2;E9PMM2 P17480 UBTF Nucleolar transcription factor 1 1 26777900.0 2724400.0 3958500.0 20095000.0 True False 3526789.5059527038 3738205.9951988417 16437916.192111934 1.0 1.0599458768064547 4.660872491643502 21.749924041379685 -6.910515302493191 0.8922206017499779 0.8903174569527312 5.131394243113354 0.9911145482286561 0.1613586017862401 0.10407812791471119 0.1369269743583847 0.1324440282536779 0.36692292596796683 1.2288098883396012e-07 6.910515302493191 4.2410767861606224 up TTFFNVSSSTLTSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTFFNVSSSTLTSK 14 0 O75449-2;O75449 O75449-2 KATNA1 Katanin p60 ATPase-containing subunit A1 0 5106200.0 1747500.0 1183100.0 2175600.0 False True 2290989.4228140707 1006586.09168768 1950489.781828821 1.0 0.4393674111560363 0.8513744159643448 21.127539367255757 -9.753461683455406 6.0246746592580465 1.000000010959394 0.6453709135590925 0.4969365887101428 0.16820115537607913 2.4757059186911105e-08 5.035135603867528e-09 0.1628600744613704 0.054286689464787936 1.7641614044628864e-10 9.753461683455406 -0.3546290974003016 TTFYTALGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTFYTALGR 9 0 E7ESC6;Q9UIA9 E7ESC6 XPO7 Exportin-7 0 13926000.0 4974100.0 4874600.0 4077300.0 False True 6521093.269252913 4147328.681041975 3655420.1082233205 1.0 0.6359867141598348 0.5605532626651271 22.636682423643695 -13.999999999999998 0.22123557387433418 3.208586701319908 0.520678365481014 0.9994991601175311 0.004293827837040411 13.033501743065417 0.14899595652224673 12.584155333021062 0.041409068163689 1.0000000000000041e-14 13.999999999999998 -2.6879083358388938 TTFYTALGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTFYTALGR 9 0 E7ESC6;Q9UIA9 E7ESC6 XPO7 Exportin-7 0 11415600.0 4974100.0 3224100.0 3217400.0 False True 6813159.189998193 3081648.601327048 2457516.384432973 1.0 0.45230832208514204 0.3607014478746716 22.699892485166586 -13.999999999999998 0.25161082892509723 4.840078181861808 0.3244280664700237 0.9995457394209746 0.006016016383326103 14.062432340747163 0.15872421849619425 27.319394904517427 0.041900828119884465 1.0000000000000041e-14 13.999999999999998 -4.515650115391785 TTGAFWQTWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTGAFWQTWK 10 0 Q9HCS7 Q9HCS7 XAB2 Pre-mRNA-splicing factor SYF1 0 5759800.0 1399000.0 1568000.0 2792800.0 False True 1834102.5479352726 1334060.5120161297 2503827.8464292735 1.0 0.7273641888333553 1.3651515010695228 20.806642874157713 -6.790542584036654 1.4940870198468734 0.8477309605034761 1.3720435324231335 0.8030972341487204 0.1159428267397666 0.2345457582482995 1.0343174532446897 0.06107816901134567 0.14294741461078309 1.6197851607262486e-07 6.790542584036654 0.5243125719196574 TTGAFWQTWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTGAFWQTWK 10 0 Q9HCS7 Q9HCS7 XAB2 Pre-mRNA-splicing factor SYF1 0 4177800.0 1399000.0 1088800.0 1690000.0 False True 1916248.1065534442 1040693.2158198867 1290856.8066425452 1.0 0.5430889728009559 0.6736376162501602 20.869852935680605 -10.499662706469145 9.269774846707014 1.00000901299915 0.6083632945255637 0.9230735771745318 0.053296260510514025 9.927653914622795e-06 5.359025107488596e-07 0.05160506771659348 0.017201294114362737 3.164734587763044e-11 10.499662706469145 -0.3916457184735862 TTGASFEK(ub)AQQEFATGVMSNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTGASFEKAQQEFATGVMSNK 21 1 A0A087WXB0;O15126;A0A087WU14 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 15295500.0 3599300.0 4437800.0 7258400.0 True False 4718717.155670779 3775697.5384089164 6507370.395489213 1.0 0.8001533920869623 1.3790549805827834 22.16996326689756 -6.813500078464691 1.399825300526975 0.891526102830311 1.3900080241617112 0.8687486633350495 0.08697791537442612 0.20207237743662038 0.7797248484030184 0.04884810079949223 0.11282434102252949 1.536384515750481e-07 6.813500078464691 0.49848192133140024 TTGASFEK(ub)AQQEFATGVMSNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTGASFEKAQQEFATGVMSNK 21 1 A0A087WXB0;O15126;A0A087WU14 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 18826600.0 5953800.0 4387600.0 8485200.0 True False 5764799.8779453505 6139591.56103174 6262671.569456409 1.0 1.0650138237270381 1.0863640893096373 22.4588390956562 -13.999999986475753 0.15566493090347744 0.682573093147568 1.1083897628465458 0.9995484219985937 0.0007804901187037377 11.983733745606882 0.12452250786353883 1.149118050252089 0.01997115769533199 1.0000000311407291e-14 13.999999986475753 0.4258166696989778 TTGASFEK(ub)AQQEFATGVMSNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTGASFEKAQQEFATGVMSNK 21 1 A0A087WXB0;O15126;A0A087WU14 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 11810500.0 3599300.0 3665000.0 4546200.0 True False 4930058.477425164 3503068.1814657245 3472481.1919280174 1.0 0.7105530689963099 0.7043488850748075 22.233173328420452 TTGASFEK(ub)AQQEFATGVMSNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTGASFEKAQQEFATGVMSNK 21 1 A0A087WXB0;O15126;A0A087WU14 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 17395800.0 5953800.0 6837600.0 4604400.0 True False 4950848.49806142 6800764.491642666 5567158.751659782 1.0 1.3736563529071044 1.124485783364142 22.239244371090475 -10.26367003349488 4.716042081735388 0.9999161003449704 1.249071068136249 0.571232929958444 0.10172345905196856 8.976496658807968e-05 1.401529138664376e-05 0.09852641001082477 0.03283110523526968 5.44916510065438e-11 10.26367003349488 0.24915496779127855 TTGFGMIYDSLDYAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 TTGFGMIYDSLDYAK 15 0 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4;A0A2R8Y8A0 E7ETK0 RPS24 40S ribosomal protein S24 0 73786380.0 17654180.0 29471100.0 26661100.0 False True 23144800.943322293 25074126.757448044 23902465.12332983 1.0 1.083358928808692 1.0327358261521855 24.464184819007393 -10.26495148231404 3.7722089847776603 0.9999025383058564 1.0580473774731105 0.6367729307503015 0.020666795187302564 14620823.081448141 2.048281800958327 12439.574823665498 0.007074793687132246 5.433110246911707e-11 10.26495148231404 0.0581448391672541 TTGFGMIYDSLDYAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 TTGFGMIYDSLDYAK 15 0 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4;A0A2R8Y8A0 E7ETK0 RPS24 40S ribosomal protein S24 0 120555300.0 40706000.0 26506700.0 53342600.0 False True 39413810.31133789 37090963.54061439 39370572.81630199 1.0 0.9410651557823299 0.9989029861692041 25.232197892285285 -9.907034929221698 4.269207049268534 1.0000005777364653 0.9699840710467531 0.26422026035105994 0.02361219546807682 15200469.334761549 103.08171115839284 96.75818266048275 0.008520326070882744 1.2386969572179963e-10 9.907034929221698 -0.03001650668971223 TTGFGMIYDSLDYAK ddPTM_RPMI8226_Bortezomib_8h_R1 2 TTGFGMIYDSLDYAK 15 0 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4;A0A2R8Y8A0 E7ETK0 RPS24 40S ribosomal protein S24 0 151546600.0 37996100.0 82284000.0 31266500.0 False True 57642861.586993136 67599777.31217355 25086662.570406247 1.0 1.172734584145405 0.43520848687475544 25.780638621772923 -6.845000634631583 1.2590363894748036 1.0919189928396076 0.4084588329649923 0.9327009982713685 0.08170585862384294 0.16304251355692673 0.4998789366565052 0.05084062001007102 0.11732826355852949 1.4288918704795725e-07 6.845000634631583 -0.6834601598746153 down TTGFGMIYDSLDYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TTGFGMIYDSLDYAK 15 0 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4;A0A2R8Y8A0 E7ETK0 RPS24 40S ribosomal protein S24 0 78001880.0 17654180.0 24379900.0 35967800.0 False True 24181407.432275653 23302715.40445189 27472946.420093335 1.0 0.9636624944067175 1.1361185860267324 24.527394880530284 -6.851663930659517 1.2270009016472274 0.9805777788407302 1.1432385899635893 0.9426985781698517 0.017768777355533207 0.15563351665433042 0.45005174244918145 0.011326619953979052 0.02624040158919757 1.4071359845163873e-07 6.851663930659517 0.16266081112285913 TTGFGMIYDSLDYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TTGFGMIYDSLDYAK 15 0 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4;A0A2R8Y8A0 E7ETK0 RPS24 40S ribosomal protein S24 0 76159900.0 40706000.0 21497900.0 13956000.0 False True 33848842.58155938 21382086.545700945 16874135.074746754 1.0 0.6316932844655008 0.49851438890674704 25.01260316771956 -13.999999999999998 0.14154529717874517 2.7618884148705845 0.3367270589762169 0.9995968450034601 0.00425867462790174 11.935897467214945 0.11798536099697862 5.803621260316911 0.14479129394820783 1.0000000000000041e-14 13.999999999999998 -2.4251613558943674 TTGFGMIYDSLDYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TTGFGMIYDSLDYAK 15 0 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4;A0A2R8Y8A0 E7ETK0 RPS24 40S ribosomal protein S24 0 113891200.0 37996100.0 43403500.0 32491600.0 False True 49186700.46510408 40988057.070257135 26578462.191969335 1.0 0.8333158492575947 0.5403587136491428 25.551764943865372 -6.962490981896591 0.39877685747874597 1.0163230984529912 0.3466755864735884 0.9998517207874026 0.0023135421373113984 0.07882300540626931 0.017929359444060586 0.00377018774428969 0.024556299023379812 1.0902071302471576e-07 6.962490981896591 -0.6696475119794028 TTGFGMIYDSLDYAK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTGFGMIYDSLDYAKK 16 1 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4;A0A2R8Y8A0 E7ETK0 RPS24 40S ribosomal protein S24 1 22996600.0 6884000.0 7252100.0 8860500.0 True False 9024990.664750824 6170114.948464393 7943700.45591757 1.0 0.6836699535394751 0.88018932661543 23.105494009033162 -10.410645959834492 5.694130271295782 1.0000961022450219 0.7819296412048095 0.6214707642520161 0.08022869810129038 9.792362090163785e-05 1.0135211405154449e-05 0.0777152134596953 0.02589370096951645 3.884669181321532e-11 10.410645959834492 -0.21816646104021242 TTGFGMIYDSLDYAK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTGFGMIYDSLDYAKK 16 1 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4;A0A2R8Y8A0 E7ETK0 RPS24 40S ribosomal protein S24 1 35254000.0 9833000.0 11574000.0 13847000.0 True False 9520856.79731208 16195558.557612648 10220055.298904307 1.0 1.7010610391897674 1.0734386113012038 23.18265997916121 -10.361081089553455 4.208760209234623 0.9992076177981588 1.3872498252509502 0.3366954586649058 0.2562257832605906 0.0019088643867294197 0.00028977853701165186 0.24858224379203112 0.08269651595056694 4.354305644171708e-11 10.361081089553455 0.3880422074527914 TTGFGMIYDSLDYAK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTGFGMIYDSLDYAKK 16 1 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4;A0A2R8Y8A0 E7ETK0 RPS24 40S ribosomal protein S24 1 84550000.0 17664000.0 21229000.0 45657000.0 True False 26797579.411377653 17440519.08706593 36632873.93782597 1.0 0.6508244203452599 1.3670217513105856 24.675599354114052 -6.774104279527568 1.5584997895003638 0.8007788751243012 1.3717160352192665 0.7461171632722455 0.14733932699065774 0.25983150564695395 1.2459989486824232 0.07449034455160863 0.17667657681945273 1.6822700785216394e-07 6.774104279527568 0.5709371600949653 TTGFGMIYDSLDYAK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTGFGMIYDSLDYAKK 16 1 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4;A0A2R8Y8A0 E7ETK0 RPS24 40S ribosomal protein S24 1 23110800.0 6884000.0 6208800.0 10018000.0 True False 9429200.833105 5934474.686244034 7651954.727186404 1.0 0.6293719681320897 0.8115167830895214 23.168704070556053 -10.109547037584834 5.051624816046188 1.0000088763392825 0.7204443756100811 0.7585013187905676 0.07436030932574446 7.4340085936649315e-06 1.3102621517510821e-06 0.07200134545832644 0.023999686636092768 7.770571526973715e-11 10.109547037584834 -0.27956450072920136 TTGFGMIYDSLDYAK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTGFGMIYDSLDYAKK 16 1 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4;A0A2R8Y8A0 E7ETK0 RPS24 40S ribosomal protein S24 1 35919000.0 9833000.0 14756000.0 11330000.0 True False 8176575.17575968 14676506.499163333 13699050.615998881 1.0 1.7949454611110758 1.6754020260965938 22.963065254595485 -10.130643990340415 4.4956115111533865 0.9999094008214515 1.7351737436158106 0.9805551419069407 0.0488034030602002 7506999.831617611 8458338.098862197 5518.790605998448 0.016706704181855103 7.402118095284911e-11 10.130643990340415 0.735264342794359 TTGFGMIYDSLDYAK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTGFGMIYDSLDYAKK 16 1 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4;A0A2R8Y8A0 E7ETK0 RPS24 40S ribosomal protein S24 1 90115000.0 17664000.0 23098000.0 49353000.0 True False 22866396.20949514 21812575.99522618 40371260.40454346 1.0 0.9539140228038484 1.7655278966862094 24.4467256762065 -6.893445161627568 1.0017607443110863 0.9599240873751999 1.8402395208378821 0.9830139498504729 0.048510552447476575 0.11639311891518168 0.20586681389216563 0.03671988353761646 0.0927565679018907 1.2780705813743104e-07 6.893445161627568 0.8803154334626823 TTGFGMIYDSLDYAKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTGFGMIYDSLDYAKK 16 1 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4;A0A2R8Y8A0 E7ETK0 RPS24 40S ribosomal protein S24 1 5946700.0 1663600.0 2004900.0 2278200.0 True False 2180995.7103253193 1705776.7350389904 2042473.7180375177 1.0 0.7821091655354769 0.9364868112156262 21.056555501751955 -9.906819024874762 5.3221083132176945 1.0000002139305175 0.859297988453496 0.5255195299343576 0.06302440993883941 1.599849090519367e-07 3.280449661553456e-08 0.06102321527251179 0.020341040840883364 1.2393129138029611e-10 9.906819024874762 -0.1407022254770215 TTGFGMIYDSLDYAKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTGFGMIYDSLDYAKK 16 1 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4;A0A2R8Y8A0 E7ETK0 RPS24 40S ribosomal protein S24 1 21468400.0 5691800.0 5753600.0 10023000.0 True False 7368147.302151524 5433407.102179123 8198916.844664737 1.0 0.7374183603241142 1.112751483981682 22.81287047303888 -6.718628907959852 1.76415387935902 0.8400146322479889 1.112125024874871 0.5060546102197138 0.11051450855988613 0.3580023967500553 2.1767226851516406 0.04975393049174355 0.1251073159908288 1.9114858701998195e-07 6.718628907959852 0.2721103926268822 TTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSR 56 1 P53396;P53396-2;P53396-3;K7EIE7 P53396 ACLY ATP-citrate synthase 0 174579000.0 35166000.0 45262000.0 94151000.0 False True 53349392.97896887 37184642.46637988 75542013.5821508 1.0 0.6970021660984713 1.4159863751763884 25.668968520055735 -6.792217285971775 1.4873387975609593 0.8311352989503543 1.4241178055150316 0.8084283387389017 0.12899997084365208 0.23208404275207195 1.0141766800856888 0.06825735488271494 0.1595615123544762 1.613551063877195e-07 6.792217285971775 0.5929825065646773 TTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSR 56 1 P53396;P53396-2;P53396-3;K7EIE7 P53396 ACLY ATP-citrate synthase 0 109649000.0 35166000.0 51390000.0 23093000.0 False True 45523080.22549286 48530101.3245594 18890310.95418965 1.0 1.066054868962549 0.41496117706927715 25.440094842148184 -6.881907367561483 1.0691361137495703 1.0420670034112778 0.3671029889003736 0.9751903577164887 0.04608836312751859 0.1259525056247451 0.26220734801119283 0.033148831891024466 0.08056311303883655 1.3124798133299893e-07 6.881907367561483 -0.6749640145109042 down TTGIVETHFTFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTGIVETHFTFK 12 0 P04899-4;P04899;P04899-6;P04899-3;P04899-5;P04899-2;P63096;P09471-2;P09471;P63096-2;A0A1W2PP38;H3BTM2;A0A3B3ITM0;P08754 P04899-4;P08754 GNAI2;GNAI1;GNAO1;GNAI3 Guanine nucleotide-binding protein G(i) subunit alpha-2;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(o) subunit alpha;Guanine nucleotide-binding protein G(k) subunit alpha 0 10613800.0 3503900.0 3592200.0 3517700.0 False True 4593646.831815867 3056257.7622859264 3153722.148161078 1.0 0.665322754269681 0.6865399678351879 22.13120851320293 -10.408446448089839 5.901334671392458 1.0001046360939827 0.6759313610524347 0.9967954269304038 0.008661891166525682 1.1928495115500538e-05 1.1957131653155721e-06 0.008389530871571136 0.0027956133528844736 3.904393237652774e-11 10.408446448089839 -0.324173275041548 TTGIVETHFTFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTGIVETHFTFK 12 0 P04899-4;P04899;P04899-6;P04899-3;P04899-5;P04899-2;P63096;P09471-2;P09471;P63096-2;A0A1W2PP38;H3BTM2;A0A3B3ITM0;P08754 P04899-4;P08754 GNAI2;GNAI1;GNAO1;GNAI3 Guanine nucleotide-binding protein G(i) subunit alpha-2;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(o) subunit alpha;Guanine nucleotide-binding protein G(k) subunit alpha 0 7762630.0 2919230.0 2137200.0 2706200.0 False True 2826560.641555713 2990595.105350768 1997365.035740221 1.0 1.058033237066788 0.7066414943925949 21.430616218496244 -6.864497964973368 1.1628945027613597 1.0319448464967709 0.6881118474650831 0.9588716508444428 0.031191804367544033 0.14223450151582154 0.3629914469448835 0.020879738403931255 0.049010532425170374 1.3661614772648993e-07 6.864497964973368 -0.34383299903168774 TTGIVETHFTFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTGIVETHFTFK 12 0 P04899-4;P04899;P04899-6;P04899-3;P04899-5;P04899-2;P63096;P09471-2;P09471;P63096-2;A0A1W2PP38;H3BTM2;A0A3B3ITM0;P08754 P04899-4;P08754 GNAI2;GNAI1;GNAO1;GNAI3 Guanine nucleotide-binding protein G(i) subunit alpha-2;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(o) subunit alpha;Guanine nucleotide-binding protein G(k) subunit alpha 0 9597500.0 3503900.0 2815900.0 3277700.0 False True 4799386.519337105 2691484.2270639385 2503574.7663504556 1.0 0.5607975553166509 0.521644746940751 22.194418574725823 -13.999999999999968 0.342195804541302 6.148418903446875 0.515663134904964 0.9997395621280626 0.0034997056390661556 19.907296438727496 0.1877853212424466 74.21932018608912 0.012002891956121609 1.0000000000000737e-14 13.999999999999968 -5.632755768541911 TTGIVETHFTFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTGIVETHFTFK 12 0 P04899-4;P04899;P04899-6;P04899-3;P04899-5;P04899-2;P63096;P09471-2;P09471;P63096-2;A0A1W2PP38;H3BTM2;A0A3B3ITM0;P08754 P04899-4;P08754 GNAI2;GNAI1;GNAO1;GNAI3 Guanine nucleotide-binding protein G(i) subunit alpha-2;Guanine nucleotide-binding protein G(i) subunit alpha-1;Guanine nucleotide-binding protein G(o) subunit alpha;Guanine nucleotide-binding protein G(k) subunit alpha 0 6069830.0 2919230.0 1804200.0 1346400.0 False True 2427469.0888165273 1794480.4164943409 1627926.0149497725 1.0 0.7392392450069097 0.6706268773718725 21.21102149393052 -13.999999999999998 0.18742309546945776 2.38561753075766 0.6201067660124223 0.999491032606726 0.003201037116448445 12.30989121801599 0.13728384732755625 6.223959958669393 0.048170858301841916 1.0000000000000041e-14 13.999999999999998 -1.7655107647452377 TTGIVMDSGDGVTHTVPIYEGYALPHAILR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TTGIVMDSGDGVTHTVPIYEGYALPHAILR 30 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 163417600.0 56221400.0 84505300.0 22690900.0 False True 73706799.8488121 71897438.63907953 20343063.334482245 1.0 0.9754519092750743 0.27599981787582795 26.135294386050585 -6.914344589740179 0.8656340858383962 1.0187959651188907 0.1766786619041467 0.9924601126358821 0.029146253288690426 0.10161482556525438 0.12370566836637963 0.024387302679143717 0.0695289326309953 1.218022778653209e-07 6.914344589740179 -0.842117303214744 down TTGIVMDSGDGVTHTVPIYEGYALPHAILR ddPTM_RPMI8226_Bortezomib_2h_R1 2 TTGIVMDSGDGVTHTVPIYEGYALPHAILR 30 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 1081644600.0 560130400.0 195491200.0 326023000.0 False True 542349367.0518794 273551855.6331406 240627795.81964916 1.0 0.5043831010998 0.4436767339245949 29.01464725594912 -13.999999999999998 0.2961635432256056 5.422618803462033 0.42813787780191015 0.999641258883437 0.004719584688149366 16.342845278162283 0.1727275052824248 44.1943352296581 0.022307289507006948 1.0000000000000041e-14 13.999999999999998 -4.994480925660123 TTGIVMDSGDGVTHTVPIYEGYALPHAILR ddPTM_RPMI8226_Bortezomib_8h_R1 2 TTGIVMDSGDGVTHTVPIYEGYALPHAILR 30 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 3684655800.0 545886800.0 2449084000.0 689685000.0 False True 828150185.2707666 2012025825.4193707 553368457.4503256 1.0 2.429542202857241 0.6681981931446406 29.625317183704464 -6.690804906561205 1.863369602075792 1.8955417052079953 0.6741926472461663 0.37429229265872876 0.6044951763780405 0.4149333172088146 2.793859333499142 0.25945224879168405 0.6749933687159144 2.0379573617738967e-07 6.690804906561205 -1.221349057961829 TTGIVMDSGDGVTHTVPIYEGYALPHAILR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TTGIVMDSGDGVTHTVPIYEGYALPHAILR 30 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 175775700.0 56221400.0 79293900.0 40260400.0 False True 77007970.90620716 75790433.30813776 30751722.708965465 1.0 0.9841894600813166 0.39933168407228803 26.198504447573477 -6.912694478582187 0.8771815447524267 1.0166021186328202 0.31922405775601986 0.9918992938096225 0.02515661050984244 0.10266339997679773 0.12930084438006195 0.020874425285913434 0.05875784438393874 1.22265948526537e-07 6.912694478582187 -0.6973780608768003 down TTGIVMDSGDGVTHTVPIYEGYALPHAILR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TTGIVMDSGDGVTHTVPIYEGYALPHAILR 30 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 922755500.0 560130400.0 239765100.0 122860000.0 False True 465773245.5840878 238473437.8166539 148549457.95954332 1.0 0.5119947100387959 0.3189308517994839 28.795052531383398 -13.999999999999996 0.12804492012156649 3.3188794819002063 0.041723007204083715 0.9996545549318383 0.005326867325758145 11.940157554209527 0.11107972239738247 6.981115023696118 0.24636431658267108 1.0000000000000082e-14 13.999999999999996 -3.2771564746961226 TTGIVMDSGDGVTHTVPIYEGYALPHAILR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TTGIVMDSGDGVTHTVPIYEGYALPHAILR 30 0 P60709;A0A2R8Y793;A0A2R8YEA7;P63261;I3L3I0;I3L1U9;I3L4N8 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 1820162800.0 545886800.0 672624900.0 601651100.0 False True 706661223.6375353 635192733.0301939 492156773.2616054 1.0 0.8988645644946277 0.69645362841367 29.396443505796913 -6.960031452814487 0.4349926890820372 1.0076270323825756 0.5798647324216608 0.9997713559451833 0.0019082656988478705 0.07968992311553888 0.021090032912069095 0.0026530245508692724 0.01678780646079662 1.0963987890175465e-07 6.960031452814487 -0.42776229996091475 TTGK(ub)MENYELIHSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTGKMENYELIHSSR 15 1 Q9Y2I1;Q9Y2I1-2 Q9Y2I1 NISCH Nischarin 1 17529000.0 7483100.0 6173700.0 3872200.0 True False 9810416.566443477 5252608.024894117 3471541.8887651945 1.0 0.5354113140170479 0.3538628421385898 23.225882966276615 -13.999999999999998 0.12991876103431402 3.207809226547346 0.09935419786068125 0.9996459843036287 0.005119449232110138 11.936831453107722 0.11208087982496207 6.730274599425592 0.22633506969904144 1.0000000000000041e-14 13.999999999999998 -3.108455028686665 TTGK(ub)MENYELIHSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTGKMENYELIHSSR 15 1 Q9Y2I1;Q9Y2I1-2 Q9Y2I1 NISCH Nischarin 1 14600100.0 4117200.0 3200300.0 7282600.0 True False 3986501.739641341 4478196.479344028 5375068.586683076 1.0 1.123339903458044 1.348317130589453 21.92669186799544 -6.961805268995151 0.40919957556827424 0.9888202525298835 1.4911750064062221 0.9998313975601794 0.0018724326361774534 0.07906247544789828 0.018794396884510574 0.0028963895359438783 0.018788803827456027 1.0919298313391185e-07 6.961805268995151 0.5023547538763387 TTGK(ub)MENYELIHSSR ddPTM_RPMI8226_Bortezomib_8h_R1 2 TTGKMENYELIHSSR 15 1 Q9Y2I1;Q9Y2I1-2 Q9Y2I1 NISCH Nischarin 1 54499000.0 22763600.0 23003700.0 8731700.0 True False 34534045.44207632 18898510.00627155 7005875.667759931 1.0 0.5472428661151173 0.20286866418563185 25.04151601077942 -8.015992859382486 0.30723471679011327 1.119965399634972 5.535389261628292e-22 0.9990914679295214 0.009839166891216642 0.09759186819341376 0.06054194158864332 0.05906272890649334 0.08984345832813538 9.638448709148597e-09 8.015992859382486 -1.119965399634972 down TTGK(ub)MENYELIHSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTGKMENYELIHSSR 15 1 Q9Y2I1;Q9Y2I1-2 Q9Y2I1 NISCH Nischarin 1 19215300.0 7483100.0 4641900.0 7090300.0 True False 10249804.293173742 4436805.5092894295 5415717.169312218 1.0 0.4328673389641492 0.5283727390696646 23.289093027799506 -10.487759308090707 6.578387568278187 1.000221700866128 0.4806200390169069 0.9752673619852134 0.03898991632314393 0.0001268298195883983 9.875891188530002e-06 0.03776751065304122 0.012583941382463092 3.252675151225417e-11 10.487759308090707 -0.5196016618492212 TTGK(ub)MENYELIHSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TTGKMENYELIHSSR 15 1 Q9Y2I1;Q9Y2I1-2 Q9Y2I1 NISCH Nischarin 1 22492100.0 5776800.0 11392900.0 5322400.0 True False 4803665.155631902 11331524.186386412 6435289.232002869 1.0 2.3589329853895276 1.3396623252264 22.19570415934656 -10.133108306671652 4.708375540260228 0.9999308696762478 1.849297655316112 0.4807136459182373 0.4161155045635609 290601844.95694107 30.399576252225327 221714.10481391056 0.1424474052308761 7.360235211381099e-11 10.133108306671652 0.8493667856398642 TTGK(ub)MENYELIHSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTGKMENYELIHSSR 15 1 Q9Y2I1;Q9Y2I1-2 Q9Y2I1 NISCH Nischarin 1 45500900.0 19373800.0 21062300.0 5064800.0 True False 25079766.014691893 19890164.489750277 4143058.3692365554 1.0 0.7930761586092345 0.16519525608052021 24.580020552582017 -7.076098287054049 0.6020508763152734 1.0036666839944954 1.0152814838475862e-20 0.9988763466958408 0.011898493536003316 0.07560792318511979 0.04263876627275621 0.012280166069390128 0.04628003747988143 8.392700262117421e-08 7.076098287054049 -1.0036666839944954 down TTGLVGLAVCNTPHER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTGLVGLAVCNTPHER 16 0 F8WAS3;Q16718 F8WAS3 NDUFA5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 0 20552050.0 508750.0 7360300.0 12683000.0 False True 666976.1767420081 6262171.930224683 11370684.823926713 1.0 9.388898957101647 17.048112392063725 19.34727570614657 -7.686222376215667 0.3588380844028236 1.619669850134622e-16 20.97721033163089 0.9984616756286149 0.2570525306180417 0.14237285563378682 0.06240917046303137 0.6810062844166846 1.7517599013512548 2.0595750580882458e-08 7.686222376215667 20.97721033163089 TTGLVGLAVCNTPHER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTGLVGLAVCNTPHER 16 0 F8WAS3;Q16718 F8WAS3 NDUFA5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 0 12322800.0 5468200.0 2777000.0 4077600.0 False True 5294614.984141352 3885870.5818636846 3009554.2346221 1.0 0.7339288302365335 0.5684179574221053 22.336094346900513 -9.591465734172209 0.08820152476668254 1.751008469006023 2.0598652819695852e-11 0.9999658014838112 0.0010396310496152419 1.0771262034787576 0.036047037235964204 0.4485891464688897 0.26389556223317684 2.5617353769954424e-10 9.591465734172209 -1.7510084689854244 TTGLVGLAVCNTPHER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTGLVGLAVCNTPHER 16 0 F8WAS3;Q16718 F8WAS3 NDUFA5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 0 23867350.0 508750.0 6954300.0 16404300.0 False True 696848.6234517971 6647036.031205201 12529942.197163504 1.0 9.538708705887247 17.980866683925125 19.41048576766946 -7.561029288606696 0.35652519730898347 1.1397827136841872e-16 22.683215225856788 0.9987977505239126 0.2403719935388087 0.14783460833042303 0.05329182618735121 0.5926834303750046 1.790197283665418 2.747708842718142e-08 7.561029288606696 22.683215225856788 TTGLVGLAVCNTPHER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTGLVGLAVCNTPHER 16 0 F8WAS3;Q16718 F8WAS3 NDUFA5 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 0 10280700.0 5468200.0 2145200.0 2667300.0 False True 4547050.582333883 2133643.3818111406 3225020.097798219 1.0 0.4692367817725038 0.7092553820113652 22.11649962233479 -10.362672095752222 5.907408027748503 1.0000705709131361 0.589246081891936 0.7961231610426248 0.09798718322704636 9.108947962685464e-05 9.827192361136384e-06 0.0948918947575359 0.0316252273983435 4.338383145892584e-11 10.362672095752222 -0.41082448902120017 TTGYSDRPTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTGYSDRPTAR 11 1 Q9NP61-2;Q9NP61 Q9NP61-2 ARFGAP3 ADP-ribosylation factor GTPase-activating protein 3 0 2428590.0 544940.0 1065700.0 817950.0 False True 714421.6172064664 906701.7140660636 733316.3803304306 1.0 1.269140927749991 1.0264476363381143 19.446416209101894 -10.631043746535147 3.2535954379067493 0.9906845477697008 1.147794282098815 0.33086569830399104 0.09907912150271453 73167725.10918202 68104853.638668 5618742.014751465 0.03625924156396158 2.338601659169523e-11 10.631043746535147 0.15710973432911413 TTGYSDRPTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTGYSDRPTAR 11 1 Q9NP61-2;Q9NP61 Q9NP61-2 ARFGAP3 ADP-ribosylation factor GTPase-activating protein 3 0 2492310.0 843350.0 642760.0 1006200.0 False True 816578.3158764512 899417.4199491203 742646.0346470362 1.0 1.1014466126053764 0.9094608811035327 19.639231731942477 -6.7631578835317 1.600777448917342 1.0586944922390464 0.9086526226388506 0.7036553698954118 0.042689922774366944 0.2776426593397322 1.402909293563331 0.021035426095682958 0.05039115852306645 1.7252105944538423e-07 6.7631578835317 -0.15004186960019583 TTGYSDRPTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTGYSDRPTAR 11 1 Q9NP61-2;Q9NP61 Q9NP61-2 ARFGAP3 ADP-ribosylation factor GTPase-activating protein 3 0 2574870.0 544940.0 931430.0 1098500.0 False True 746419.0444497733 890276.3427728845 839056.924317656 1.0 1.1927299408995606 1.1241097484807228 19.509626270624786 -10.121420652495198 4.557460224899452 0.999984306524079 1.1584198446942158 0.8766417675872127 0.028014076260175023 4.467479791470712e-06 8.612310785831072e-07 0.027127198844972885 0.009041504232632391 7.561001905378741e-11 10.121420652495198 0.15843553817013678 TTHFVEGGDAGNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTHFVEGGDAGNR 13 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 18998400.0 3065300.0 8028900.0 7904200.0 False True 4018637.984407422 6831019.416407084 7086349.206440238 1.0 1.699834481959282 1.7633708818599079 21.93827518861585 -11.279743301039023 0.41282704321610697 7.708690770150566e-12 1.7668558907435554 0.9996435161680626 0.006530006841806421 3.4138324376574096 0.2046394471893478 3.133689751065859 0.015680106390226673 5.251177505183481e-12 11.279743301039023 1.7668558907358467 TTHFVEGGDAGNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTHFVEGGDAGNR 13 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 17761000.0 5674900.0 3917000.0 8169100.0 False True 5494753.405783209 5481078.526885147 6029367.642253134 1.0 0.9975112843310368 1.0972954010833764 22.3896233065066 -6.901179788188314 0.9537685174466146 0.9959845724057244 1.108024446063187 0.9871444743256497 0.005268096951846352 0.11054243036430576 0.172557961772402 0.004133206052695202 0.010819100497199696 1.2555101030348372e-07 6.901179788188314 0.1120398736574626 TTHFVEGGDAGNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTHFVEGGDAGNR 13 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 13848200.0 3065300.0 5618600.0 5164300.0 False True 4198624.246617774 5370351.673774438 3944598.7020971007 1.0 1.2790741343668837 0.939497909410373 22.001485250138742 -6.688359713043608 1.8725747429308999 1.1752309896004778 0.9407038201160461 0.3626724341081896 0.11806826955920914 0.4201684053481029 2.8553273000415254 0.050468406154968615 0.13167959258489118 2.049463966335524e-07 6.688359713043608 -0.23452716948443164 TTHFVEGGDAGNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTHFVEGGDAGNR 13 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 11856200.0 5674900.0 3899200.0 2282100.0 False True 4718930.790696489 3878194.2356694015 2759276.558761789 1.0 0.8218374898219266 0.5847249474821254 22.170028581940876 -6.967168919027558 0.31864096456523733 1.0329947477700574 0.36593502850820686 0.9999511249990721 0.001189192573835382 0.07723246601190605 0.01230418859143487 0.0036141635538672508 0.020882202519962968 1.0785271470353816e-07 6.967168919027558 -0.6670597192618506 TTHFVEGGDAGNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTHFVEGGDAGNR 13 0 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 6293800.0 2753700.0 2270700.0 1269400.0 False True 3564718.933542053 2144333.548894282 1038382.2251439107 1.0 0.6015435126504021 0.29129427719344225 21.765356898680427 -7.8483813519289525 0.24978960266101624 1.1625273095117608 2.3044851693352578e-09 0.9996955288913549 0.005061525862250354 0.11781713081491704 0.03926815456572345 0.05297056406095918 0.08854368904499134 1.41781200091897e-08 7.8483813519289525 -1.1625273072072755 down TTHFVEGGDAGNREDQINR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTHFVEGGDAGNREDQINR 19 1 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 54623550.0 7428550.0 24957200.0 22237800.0 False True 9738900.988180522 21233683.04240366 19936845.776040167 1.0 2.180295607088892 2.0471350720411094 23.21532754611222 -10.070881326643805 4.8069206740158155 0.9999619307394005 2.113715339579662 0.9893920286921217 0.05436256084099429 2.2179790983622746e-05 4.28707865712012e-06 0.052638112828385694 0.017545441059020197 8.494125499788156e-11 10.070881326643805 1.1137534088402616 TTHFVEGGDAGNREDQINR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTHFVEGGDAGNREDQINR 19 1 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 73777200.0 18971400.0 16670700.0 38135100.0 False True 18369163.29141933 23327397.446552034 28146373.28152274 1.0 1.2699216113696812 1.5322621305604363 24.130782577932905 -6.971473964333517 0.22015308276264947 0.8792537830065716 1.9303390497783621 0.9999917087417656 0.0006256858866117991 0.07582725292389245 0.007294431145151437 0.007258120293145869 0.026580916691602417 1.0678888098468886e-07 6.971473964333517 1.0510852667717905 TTHFVEGGDAGNREDQINR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTHFVEGGDAGNREDQINR 19 1 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 206814400.0 32316000.0 148630000.0 25868400.0 False True 49025734.61605984 122105815.24850976 20755499.40147751 1.0 2.4906473346043523 0.42335927373699006 25.547035912558712 -6.7131726324469465 1.7835350971662571 1.9133717806927237 0.4276374440037092 0.4804431762844973 0.6278402429953728 0.36866611879800587 2.2878506758669577 0.2799113535100048 0.7084799489417389 1.935652387439087e-07 6.7131726324469465 -1.4857343366890146 TTHFVEGGDAGNREDQINR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTHFVEGGDAGNREDQINR 19 1 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 52010650.0 7428550.0 21107600.0 23474500.0 False True 10175085.684015417 20174996.43850093 17930306.572503224 1.0 1.9827839356866452 1.7621774527826233 23.278537607635112 -10.075502343609516 5.412916968273003 0.9999913611707497 1.8724806942352241 0.954244247163504 0.09006221951288808 9.39111357939893e-06 1.6036222875516398e-06 0.0872032308538389 0.029067456357690598 8.404224718652103e-11 10.075502343609516 0.8724893330644744 TTHFVEGGDAGNREDQINR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTHFVEGGDAGNREDQINR 19 1 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 40741600.0 18971400.0 14776000.0 6994200.0 False True 15775559.675521923 14696398.755193625 8456654.882473027 1.0 0.93159285993493 0.5360605301119528 23.91118785336718 -6.936623902853275 0.6902642361005877 1.0048040514955545 0.4392216432289868 0.9976872890648222 0.009834314058058348 0.08934143329338565 0.06188166359956023 0.00934370421916156 0.034579353261661075 1.1571138640410581e-07 6.936623902853275 -0.5655824082665677 TTHFVEGGDAGNREDQINR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTHFVEGGDAGNREDQINR 19 1 P18124;A8MUD9 P18124 RPL7 60S ribosomal protein L7 0 82374400.0 32316000.0 25004700.0 25053700.0 False True 41833699.04359407 23613166.46410215 20494183.67267056 1.0 0.5644532279943817 0.4898965222108133 25.31816223465116 -13.999999999999998 0.2483189079704447 4.003549652563018 0.45943538919273225 0.9995395576682141 0.004827182090019543 13.931983882519491 0.1576876369272818 20.85200529538931 0.03473212410953168 1.0000000000000041e-14 13.999999999999998 -3.544114263370286 TTHLMFHTVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTHLMFHTVTK 11 0 Q68CP9-3;Q68CP9;F8WCU9 Q68CP9-3 ARID2 AT-rich interactive domain-containing protein 2 0 9246200.0 3353400.0 2627700.0 3265100.0 False True 4396339.874371798 2235657.402694375 2927258.7730507865 1.0 0.5085269716581756 0.6658399615814664 22.067871492489548 -10.369653704820077 5.074191837524284 1.0002613719973878 0.5871834666197753 0.9017847024946701 0.06422275920410192 0.00019001482791870274 2.3604585425304116e-05 0.062222202626673724 0.020727806403725096 4.2691979791645885e-11 10.369653704820077 -0.4130779053776126 TTHLMFHTVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTHLMFHTVTK 11 0 Q68CP9-3;Q68CP9;F8WCU9 Q68CP9-3 ARID2 AT-rich interactive domain-containing protein 2 0 8051000.0 3353400.0 1968900.0 2728700.0 False True 4593242.602227535 1881907.487718382 2084237.259340544 1.0 0.4097121904263741 0.45376163199604874 22.13108155401244 -9.802745254219623 6.5935055942237595 1.0000000072518294 0.4317369134753177 0.9955136778223305 0.01798310921700894 1.905703479350467e-09 3.5415768875393057e-10 0.01741207088695267 0.005804023542497604 1.5749063924656574e-10 9.802745254219623 -0.5682630937765116 TTHVVNLGSNQYLFSVIVDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTHVVNLGSNQYLFSVIVDPK 21 0 Q96RS6;Q96RS6-2;Q96RS6-3 Q96RS6 NUDCD1 NudC domain-containing protein 1 0 13252700.0 5825900.0 2189100.0 5237700.0 False True 5640959.993436424 3063219.0460056914 3865789.242368102 1.0 0.5430315140631949 0.6853069773347384 22.42750927448614 -10.84701366249411 10.824966247922916 1.0085177502535565 0.6141692456989691 0.9074550505348917 0.058083714655561766 0.01167754110926221 0.00016503523423863585 0.055002625980123634 0.0187464382955712 1.4222840427067053e-11 10.84701366249411 -0.39434850455458736 TTHVVNLGSNQYLFSVIVDPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTHVVNLGSNQYLFSVIVDPK 21 0 Q96RS6;Q96RS6-2;Q96RS6-3 Q96RS6 NUDCD1 NudC domain-containing protein 1 0 70821000.0 18552000.0 22419000.0 29850000.0 False True 28144740.332873534 18418154.289553523 23950134.416280217 1.0 0.6544083928904046 0.8509630621216304 24.746362001981886 -10.170805039536239 5.270810562023206 1.0000105370641632 0.7526857275059131 0.6785509742406453 0.08024310769670298 9.936303021151563e-06 1.5630703009876137e-06 0.07769836432727846 0.02589835164638559 6.748309001138638e-11 10.170805039536239 -0.2473248095582501 TTHVVNLGSNQYLFSVIVDPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTHVVNLGSNQYLFSVIVDPK 21 0 Q96RS6;Q96RS6-2;Q96RS6-3 Q96RS6 NUDCD1 NudC domain-containing protein 1 0 12413400.0 5825900.0 2605900.0 3981600.0 False True 4844493.981130706 2591861.4994693473 4814134.151161627 1.0 0.535011811257201 0.9937331267027412 22.207914549920417 -10.926338071413301 10.61750709929135 1.0389152641653536 0.7643724689799711 0.26024432368323147 0.18727219282997623 0.10562051330489641 0.0007327707924527767 0.11101698459203393 0.060441840336520176 1.1848460596557941e-11 10.926338071413301 -0.2745427951853825 TTHVVNLGSNQYLFSVIVDPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTHVVNLGSNQYLFSVIVDPK 21 0 Q96RS6;Q96RS6-2;Q96RS6-3 Q96RS6 NUDCD1 NudC domain-containing protein 1 0 55344000.0 18552000.0 22078000.0 14714000.0 False True 24015929.71459204 20849339.89187826 12036202.978389394 1.0 0.8681462737297334 0.5011758079503462 24.517488324074336 -6.953124474562919 0.5234245565152226 1.0060748204142722 0.34677466917121685 0.9994241917118398 0.0050643497912434225 0.08225493926105625 0.030954430494984635 0.005706483068562665 0.030322694746485246 1.1139752077520321e-07 6.953124474562919 -0.6593001512430554 TTHYTPLACGSNPLKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTHYTPLACGSNPLKR 16 1 O60832;O60832-2;C9IYT0;H7C0M1;H7C2Q9 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 0 12834100.0 4818700.0 3024100.0 4991300.0 False True 6237902.140777529 2855806.1766024516 4082934.6150628696 1.0 0.45781516159637714 0.6545364968732819 22.57262948944208 -10.078913651969772 5.095741350330485 1.000008986553402 0.556175829233503 0.8715756488651516 0.08031114882918368 8.199505247160176e-06 1.4821977704583337e-06 0.07776250931891543 0.025920311826855027 8.338469566658779e-11 10.078913651969772 -0.44383315731989914 TTIEAIHGLMSQVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTIEAIHGLMSQVIK 15 0 Q92905 Q92905 COPS5 COP9 signalosome complex subunit 5 0 13252900.0 2163400.0 4221400.0 6868100.0 False True 2836238.350395399 3591583.5748883197 6157454.8954672385 1.0 1.26631937488174 2.170993454978433 21.435547347488406 -6.948628781370682 0.5736987191866889 0.988911024791992 2.492666810227647 0.9990892473128355 0.015124796669829852 0.08404104518756654 0.038277260037831586 0.01595701564685124 0.07544698260200056 1.1255666550517701e-07 6.948628781370682 1.5037557854356551 up TTIEAIHGLMSQVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTIEAIHGLMSQVIK 15 0 Q92905 Q92905 COPS5 COP9 signalosome complex subunit 5 0 59474000.0 16126300.0 15065000.0 28282700.0 False True 15614379.433590323 21080533.062937155 20874612.40718721 1.0 1.3500717817570007 1.3368838957685918 23.896371897298977 -10.08596376551606 4.630860290443832 0.9999799033742727 1.3434778387717752 0.998895578675924 0.005383931940293412 1.1171501197633798e-06 2.2050680293956063e-07 0.005213274489204052 0.0017376565574884729 8.204199915612568e-11 10.08596376551606 0.3434979353975025 TTIEAIHGLMSQVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTIEAIHGLMSQVIK 15 0 Q92905 Q92905 COPS5 COP9 signalosome complex subunit 5 0 25575100.0 8525600.0 8495400.0 8554100.0 False True 12933958.504848354 6979329.495136835 6863378.385604788 1.0 0.5396127946846745 0.5306479360539172 23.624660551215644 TTIEAIHGLMSQVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTIEAIHGLMSQVIK 15 0 Q92905 Q92905 COPS5 COP9 signalosome complex subunit 5 0 43010600.0 2163400.0 20434200.0 20413000.0 False True 2963267.4436867163 19531349.477136932 15591869.81893155 1.0 6.591153126846094 5.261715358210496 21.498757409011297 -9.78822758969736 6.787699008161147 0.9999999706649899 5.9264342425287015 0.9482110709820324 0.5427406963250395 2.43202292665325e-07 3.691692692686734e-08 0.525506419543209 0.1751688065144414 1.6284424324614122e-10 9.78822758969736 4.9264342718637115 TTIEAIHGLMSQVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTIEAIHGLMSQVIK 15 0 Q92905 Q92905 COPS5 COP9 signalosome complex subunit 5 0 35001400.0 16126300.0 6284700.0 12590400.0 False True 13409732.966221211 6250843.0736847175 15222994.428567747 1.0 0.46614224827820494 1.135219803922576 23.676777172733253 -6.694143782464971 1.8514068289889123 0.6666240067265143 1.1330499747130482 0.39005060009472037 0.22559636921416976 0.4078037344121634 2.7131813873996284 0.09735856236120043 0.2522387985373715 2.0223495258240725e-07 6.694143782464971 0.4664259679865339 TTIEAIHGLMSQVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTIEAIHGLMSQVIK 15 0 Q92905 Q92905 COPS5 COP9 signalosome complex subunit 5 0 27236200.0 8525600.0 9704700.0 9005900.0 False True 11036557.264700621 9164624.913883084 7366918.608337441 1.0 0.8303880181182284 0.6675015071864693 23.395786873308094 -6.971618218156615 0.2160700467876884 1.078945293169159 0.41436561611999884 0.99999240105326 0.0003741697503679663 0.07578101652751938 0.007120606653417319 0.004650641437198228 0.01664978647410482 1.0675341623235246e-07 6.971618218156615 -0.6645796770491601 TTIESHTK(ub)SLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTIESHTKSLPK 12 1 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A0A0MSW3 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 1 5637800.0 1170400.0 1816800.0 2650600.0 True False 1133246.292644569 2542257.7144868374 1956328.3437044679 1.0 2.2433408615475527 1.7263046492207235 20.112030010855115 -10.49865071980268 5.598937794544773 0.9984642086065518 1.9848227553839854 0.8286911702949321 0.2110791497903431 0.004051283026389434 0.0003627666908858564 0.20461439668660097 0.06812550265580104 3.1721176046924303e-11 10.49865071980268 0.9863585467774336 TTIESHTK(ub)SLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTIESHTKSLPK 12 1 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A0A0MSW3 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 1 15876700.0 3785900.0 2072800.0 10018000.0 True False 5743487.086364063 1702892.6451396807 8037937.908954613 1.0 0.29649107232827493 1.3994874173283918 22.453495486486652 -6.734404613849934 1.7072352612323953 0.5787266821809818 1.3993730476816637 0.5795687979557507 0.29564910239958503 0.3280235407858691 1.8749533333931674 0.13712743500398955 0.3385804089500641 1.8432972966129456e-07 6.734404613849934 0.8206463655006819 TTIESHTK(ub)SLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTIESHTKSLPK 12 1 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A0A0MSW3 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 1 6014500.0 1170400.0 2966300.0 1877800.0 True False 973239.4575113513 2950319.9531355486 2270439.298033777 1.0 3.031443012678242 2.332868114327656 19.89243528628939 -10.18781493864431 5.4635378349903805 0.9999385584243522 2.6821555635031666 0.885467782911349 0.28519200801335837 0.00021344778977708115 3.173010061928776e-05 0.27614589137835927 0.09204532479215498 6.48910888238191e-11 10.18781493864431 1.6822170050788143 TTIESHTK(ub)SLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTIESHTKSLPK 12 1 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A0A0MSW3 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 1 11610900.0 3785900.0 1431000.0 6394000.0 True False 4900922.181245913 1351363.5920499037 5230357.6079802755 1.0 0.2757365944762583 1.0672190690958112 22.2246218085791 -12.120752468590133 18.97995370626821 0.9397815675416591 0.7043300486122119 0.0 0.3664248491707365 0.0 0.0 0.0 0.10680401517188913 7.572643840677378e-13 12.120752468590133 -0.23545151892944716 TTIFSPEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTIFSPEGR 9 0 P25789;H0YMZ1;H0YL69;H0YMA1;H0YMI6;H0YLC2;H0YLS6 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type 0 12750700.0 4385400.0 2839900.0 5525400.0 False True 4246187.877446598 3973886.879882858 4078131.9815531084 1.0 0.9358716558421608 0.9604219359237235 22.01773677567438 -10.074856351690796 6.110901073756486 1.000000115163338 0.9481467959709857 0.856075371330224 0.010022609873711433 1.5731139952309867e-08 2.366373282245034e-09 0.009704371827931593 0.003234783427200885 8.416734895992016e-11 10.074856351690796 -0.051853319192352254 TTIFSPEGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTIFSPEGR 9 0 P25789;H0YMZ1;H0YL69;H0YMA1;H0YMI6;H0YLC2;H0YLS6 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type 0 38843900.0 5788700.0 27214000.0 5841200.0 False True 8781881.110656815 22357449.076047532 4686684.259711095 1.0 2.545861051217918 0.5336765780196914 23.066098572676484 -6.701435893057924 1.8255031390280207 1.9585265981611841 0.539441127505876 0.42457223381806064 0.6523516974277601 0.3925086482873576 2.543907480286378 0.2849683268663699 0.7316339825958277 1.9886763406058464e-07 6.701435893057924 -1.419085470655308 TTIFSPEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTIFSPEGR 9 0 P25789;H0YMZ1;H0YL69;H0YMA1;H0YMI6;H0YLC2;H0YLS6 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type 0 12704900.0 3048200.0 4550000.0 5106700.0 False True 4175201.914507653 4348965.955162087 3900602.635787861 1.0 1.04161811673123 0.9342308984469382 21.99341453793243 -6.801604173417919 1.449243183149401 1.0229157761182424 0.9326871035322104 0.8368535029433007 0.01785649796008027 0.21846794958774352 0.9056905145995885 0.00969214057096516 0.02251980240659123 1.5790497985397993e-07 6.801604173417919 -0.09022867258603195 TTIFSPEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTIFSPEGR 9 0 P25789;H0YMZ1;H0YL69;H0YMA1;H0YMI6;H0YLC2;H0YLS6 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type 0 8339300.0 4385400.0 2150900.0 1803000.0 False True 3646654.406160531 2139312.674779775 2179998.9638699014 1.0 0.5866507863113364 0.5978079414893517 21.798142051108655 -10.018810965635684 5.072357227439359 1.0000042061684458 0.592229363898489 0.9994388315684553 0.004554889537764004 2.2149761292724375e-07 4.284667428916031e-08 0.004410299310815661 0.0014700842755427082 9.576107976528336e-11 10.018810965635684 -0.40777484226995675 TTIFSPEGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTIFSPEGR 9 0 P25789;H0YMZ1;H0YL69;H0YMA1;H0YMI6;H0YLC2;H0YLS6 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type 0 18568900.0 5788700.0 6112300.0 6667900.0 False True 7493586.262336087 5772145.131856475 5454410.618431605 1.0 0.770278065773148 0.7278772042494939 22.837224894768934 -13.999999998324075 0.23762747426124214 2.5032475085511865 0.7087027912974151 0.9995211039774617 0.0026160975471272606 13.540996974599427 0.15429965473748836 9.645909035152687 0.021011705464233657 1.0000000038589603e-14 13.999999998324075 -1.7945447172537714 TTIFTDAK(ub)ESSTVFELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTIFTDAKESSTVFELK 17 1 B8ZZU8;Q15370;Q15370-2;I3L0M9;A0A0B4J296 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 26871100.0 6663700.0 6649400.0 13558000.0 True False 6452164.491024961 9304540.09616291 10006753.068718465 1.0 1.4420804226404391 1.5509141285281831 22.621351788251854 -11.928467362047854 0.2336715051052689 7.932822554309807e-11 1.6075591216247929 0.999361464054507 0.006019921400006116 5.007976498562245 0.13842797732040252 2.489776745680391 0.055045606758579765 1.1790511275662725e-12 11.928467362047854 1.6075591215454645 TTIFTDAK(ub)ESSTVFELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTIFTDAKESSTVFELK 17 1 B8ZZU8;Q15370;Q15370-2;I3L0M9;A0A0B4J296 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 58906600.0 6213600.0 11260000.0 41433000.0 True False 9426485.47500772 9250565.025218448 33243749.389271006 1.0 0.9813376416634081 3.526632431292616 23.16828855306979 -6.905246230449089 0.9274866762278755 0.9088621175025896 3.8242125609548268 0.989000940179858 0.12537858430802842 0.10764656870038976 0.15643443664207773 0.100295094169919 0.2685419623531237 1.2438092135886823e-07 6.905246230449089 2.9153504434522373 up TTIFTDAK(ub)ESSTVFELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTIFTDAKESSTVFELK 17 1 B8ZZU8;Q15370;Q15370-2;I3L0M9;A0A0B4J296 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 11687500.0 2336000.0 3072100.0 6279400.0 True False 3199682.3280263366 2936364.4639238333 4796335.048302484 1.0 0.9177049978380429 1.4990035124083747 21.60949724739587 -6.871037894308223 1.1286470355210227 0.9531555753191796 1.5337171799714386 0.9657052747380724 0.04756312936663549 0.13586067135954347 0.32283277281295303 0.032685372193326116 0.07752324012700104 1.3457429263099068e-07 6.871037894308223 0.580561604652259 TTIFTDAK(ub)ESSTVFELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTIFTDAKESSTVFELK 17 1 B8ZZU8;Q15370;Q15370-2;I3L0M9;A0A0B4J296 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 26700800.0 6663700.0 7790100.0 12247000.0 True False 5541161.801963766 7748133.185086227 14807791.076269953 1.0 1.3982867604299731 2.672326058232432 22.40175706368613 -6.950000178008676 0.5588446615238635 0.983235429424531 3.1481448114244377 0.9992012763424026 0.020157552555047923 0.08348573595951075 0.03596251160213924 0.021638016141231235 0.10588073549061629 1.1220179944089936e-07 6.950000178008676 2.1649093819999066 up TTIFTDAK(ub)ESSTVFELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTIFTDAKESSTVFELK 17 1 B8ZZU8;Q15370;Q15370-2;I3L0M9;A0A0B4J296 B8ZZU8 TCEB2 Transcription elongation factor B polypeptide 2 1 44742600.0 6213600.0 9951000.0 28578000.0 True False 8043627.688367253 9397218.102367988 23377097.235042304 1.0 1.1682810873952192 2.9062878269279437 22.93941487516224 -6.925674412716257 0.781480497003714 0.9689084753202555 3.2267313357311447 0.9956177107420786 0.05704431499093837 0.09494673413463235 0.08914465518556591 0.050690118553740435 0.16116115614388046 1.1866580433239377e-07 6.925674412716257 2.257822860410889 up TTIIWDAHTGEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTIIWDAHTGEAK 13 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3;O60907;O60907-2;Q9BQ87;A0A2R8YFW3 Q9BZK7 TBL1XR1;TBL1X;TBL1Y F-box-like/WD repeat-containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1X;F-box-like/WD repeat-containing protein TBL1Y 0 21848700.0 8834900.0 8124600.0 4889200.0 False True 11582639.457293296 6912441.349442763 4383312.484518052 1.0 0.5967932762588214 0.37843813585667563 23.465460717023838 -10.03404812236171 0.13608976474324738 1.7383041715734209 2.385545647680285e-14 0.9998033396341626 0.0036105716869955532 1.617852734133668 0.06356468462395058 0.6364555344755282 0.21563446348900095 9.245957176635315e-11 10.03404812236171 -1.7383041715733971 TTIIWDAHTGEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTIIWDAHTGEAK 13 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3;O60907;O60907-2;Q9BQ87;A0A2R8YFW3 Q9BZK7 TBL1XR1;TBL1X;TBL1Y F-box-like/WD repeat-containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1X;F-box-like/WD repeat-containing protein TBL1Y 0 27338230.0 7522900.0 3962430.0 15852900.0 False True 7284089.65732726 5544648.962799468 11700549.913194217 1.0 0.7611999884188627 1.6063160207568727 22.796317249379914 -6.831252987212047 1.3224958691033881 0.8725131682116064 1.629613342067039 0.9083211514130451 0.10770839908957576 0.17927190825498845 0.612800884151745 0.06394088138491791 0.14712775147853058 1.4748471482734512e-07 6.831252987212047 0.7571001738554325 TTIIWDAHTGEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTIIWDAHTGEAK 13 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3;O60907;O60907-2;Q9BQ87;A0A2R8YFW3 Q9BZK7 TBL1XR1;TBL1X;TBL1Y F-box-like/WD repeat-containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1X;F-box-like/WD repeat-containing protein TBL1Y 0 36371800.0 10489800.0 10103000.0 15779000.0 False True 15913793.507103104 8300040.714900713 12660273.733818615 1.0 0.5215626752474826 0.7955534755536269 23.92377444843647 -10.19972240987162 5.558532922057744 1.0000121603902983 0.6585580754005321 0.6743329015146042 0.11185627582789172 1.685717056820467e-05 2.4271195870505992e-06 0.10830822791017607 0.03610145778750533 6.313607654869904e-11 10.19972240987162 -0.34145408498976615 TTIIWDAHTGEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTIIWDAHTGEAK 13 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3;O60907;O60907-2;Q9BQ87;A0A2R8YFW3 Q9BZK7 TBL1XR1;TBL1X;TBL1Y F-box-like/WD repeat-containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1X;F-box-like/WD repeat-containing protein TBL1Y 0 27849900.0 8834900.0 8515100.0 10499900.0 False True 12101401.284195142 8138874.726329817 8020039.872228455 1.0 0.67255638708217 0.6627364619916299 23.52867077854673 TTIIWDAHTGEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTIIWDAHTGEAK 13 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3;O60907;O60907-2;Q9BQ87;A0A2R8YFW3 Q9BZK7 TBL1XR1;TBL1X;TBL1Y F-box-like/WD repeat-containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1X;F-box-like/WD repeat-containing protein TBL1Y 0 15596400.0 7522900.0 6726500.0 1347000.0 False True 6255624.670977565 6690263.009394294 1628651.472175686 1.0 1.0694796061587895 0.26034993431298314 22.57672252481419 -6.886013498563256 1.0457224437229695 1.0477208485912224 0.19597002297908678 0.97821986034226 0.05403694853488123 0.12243534564300461 0.24124283606521824 0.039566023729201434 0.09732031261970682 1.3001291673228648e-07 6.886013498563256 -0.8517508256121356 down TTIIWDAHTGEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTIIWDAHTGEAK 13 0 Q9BZK7;A0A0D9SF63;A0A1B0GVH3;O60907;O60907-2;Q9BQ87;A0A2R8YFW3 Q9BZK7 TBL1XR1;TBL1X;TBL1Y F-box-like/WD repeat-containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1X;F-box-like/WD repeat-containing protein TBL1Y 0 31482200.0 10489800.0 15299900.0 5692500.0 False True 13579252.88487104 14448447.115307001 4656523.409982442 1.0 1.0640089876670866 0.34291455129835474 23.694900770528918 -6.8852508187589425 1.0500468925961863 1.043270037511725 0.2863660286149473 0.9776812028460933 0.04868618455806655 0.12308200514446059 0.24502361472778716 0.03552964042038925 0.08719110053958508 1.3024143758309119e-07 6.8852508187589425 -0.7569040088967777 down TTILQSTGK(ub)NFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTILQSTGKNFSK 13 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3 A0A3B3IRP5 CDC73 Parafibromin 1 9051200.0 3141900.0 0.0 5909300.0 True False 4119061.3262028857 0.0 5297862.322008211 1.0 0.0 1.2861819483741435 21.973884175100665 -6.69923101767537 1.8338937583161563 0.37854924724462835 1.2822608350803613 0.41374527540155925 0.4221754687532454 0.3971538052053549 2.5963113823912916 0.18370324883694988 0.47283578939601845 1.998798350286644e-07 6.69923101767537 0.9037115878357329 TTILQSTGK(ub)NFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTILQSTGKNFSK 13 1 A0A3B3IRP5;Q6P1J9;A0A2R8YHB3 A0A3B3IRP5 CDC73 Parafibromin 1 10639200.0 3141900.0 3624800.0 3872500.0 True False 4303545.336654947 3464644.3503893446 2957895.2566409823 1.0 0.8050674686472196 0.6873159279739551 22.037094236623556 TTISVAHLLAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTISVAHLLAAR 12 0 Q8NCA5;E9PH82 Q8NCA5 FAM98A Protein FAM98A 0 22051500.0 0.0 4041500.0 18010000.0 False True 0.0 5655292.026144082 13292640.711581312 0.0 TTITMAHLLAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTITMAHLLAAR 12 0 Q52LJ0;Q52LJ0-1 Q52LJ0 FAM98B Protein FAM98B 0 14860500.0 3657900.0 5113200.0 6089400.0 False True 4795542.323153995 4350330.491097497 5459327.3016493935 1.0 0.9071613173119312 1.138417082733373 22.19326254675368 -6.797737576404681 1.4650382048264252 0.9486288198502437 1.141437279728739 0.825492211723013 0.03969337075285398 0.22400279258488273 0.9493922276703163 0.021316535720748715 0.0496463518727194 1.5931711141407833e-07 6.797737576404681 0.19280845987849538 TTITMAHLLAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTITMAHLLAAR 12 0 Q52LJ0;Q52LJ0-1 Q52LJ0 FAM98B Protein FAM98B 0 11662700.0 3806700.0 1739700.0 6116300.0 False True 3685858.392182233 2434371.282415652 4514257.544933086 1.0 0.6604625092431642 1.2247506725998758 21.81356921413413 -6.743750127565912 1.672768185578159 0.7988635717102739 1.225373905194373 0.6217623346586827 0.14265347683536314 0.3110617635174732 1.7103602137183922 0.06742428751583338 0.16478968304007982 1.804055410184046e-07 6.743750127565912 0.42651033348409917 TTITMAHLLAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTITMAHLLAAR 12 0 Q52LJ0;Q52LJ0-1 Q52LJ0 FAM98B Protein FAM98B 0 14502700.0 3657900.0 4341700.0 6503100.0 False True 5010324.481030628 4149869.337918067 4967201.715548601 1.0 0.8282635892405187 0.9913932190130016 22.25647260827657 -10.568604148235117 7.582830310421496 1.000048291224243 0.9098284041307019 0.2894659283348864 0.06659739247861904 5.43990320668098e-05 3.0948016171008357e-06 0.06451713702261995 0.021494215997544204 2.7001994953658245e-11 10.568604148235117 -0.09021988709354112 TTITMAHLLAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTITMAHLLAAR 12 0 Q52LJ0;Q52LJ0-1 Q52LJ0 FAM98B Protein FAM98B 0 9124900.0 3806700.0 2966200.0 2352000.0 False True 3165439.7154036784 2950220.491855397 2843792.325580704 1.0 0.9320096912599597 0.8983877695544881 21.593974489568406 -13.99999999976448 0.0919376791783153 1.3453223718865968 0.8169044498011399 0.9998332297947671 0.0005457979146525157 12.146558040682914 0.08856801598574213 0.8144985014985886 0.07308726593798932 1.000000000542305e-14 13.99999999976448 -0.5284179220854569 TTITMAHLLAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTITMAHLLAAR 12 0 Q52LJ0;Q52LJ0-1 Q52LJ0 FAM98B Protein FAM98B 0 20281200.0 5936800.0 8400000.0 5944400.0 False True 7685304.631823525 7932532.615806557 4862580.194694706 1.0 1.0321689244378556 0.6327114444572044 22.87367101624226 -6.887396578681341 1.0376392264020695 1.0228218638516617 0.6000543330686801 0.9791797579411888 0.026145794003921932 0.12128175012564169 0.2343793363650801 0.019261288723046992 0.04759091985886201 1.2959952844068118e-07 6.887396578681341 -0.4227675307829817 TTK(ub)CIATVNTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTKCIATVNTK 11 1 Q96J01;Q96J01-2 Q96J01 THOC3 THO complex subunit 3 1 3233790.0 436830.0 1371660.0 1425300.0 True False 572688.3602677378 1167013.6746888026 1277823.6284430143 1.0 2.037781375796099 2.2312722190575314 19.127390755820784 -10.689848636366138 0.3346274394768621 1.0856745539758488e-23 2.2726926980143416 0.9992004519615123 0.015286809738110958 2.313032866043075 0.16356370408909127 1.9474142857632428 0.060656901564284625 2.042449670811992e-11 10.689848636366138 2.2726926980143416 TTK(ub)CIATVNTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTKCIATVNTK 11 1 Q96J01;Q96J01-2 Q96J01 THOC3 THO complex subunit 3 1 21349310.0 593710.0 0.0 20755600.0 True False 900701.4760150041 0.0 16653246.562497348 1.0 0.0 18.48919648291987 19.780689500080605 -6.894118067245427 0.997684585808062 0.10239161375855461 20.21402930845485 0.9834064741035897 1.0936479026720614 0.11586613730613815 0.20283023645540535 0.8303753234286245 2.1033491225390297 1.2760918434759727e-07 6.894118067245427 20.111637694696295 up TTK(ub)CIATVNTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTKCIATVNTK 11 1 Q96J01;Q96J01-2 Q96J01 THOC3 THO complex subunit 3 1 2507670.0 436830.0 1412700.0 658140.0 True False 598337.855886877 1350282.2428258199 502700.8868187727 1.0 2.2567220668737145 0.8401622626294505 19.190600817343675 -6.672631448550998 1.9283048299437429 1.800340900561537 0.8458465742173044 0.2907008230769408 0.533506476566813 0.4550675749075649 3.264760067268432 0.2225520674507093 0.5925143447857484 2.125047056744448e-07 6.672631448550998 -0.9544943263442326 TTK(ub)CIATVNTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTKCIATVNTK 11 1 Q96J01;Q96J01-2 Q96J01 THOC3 THO complex subunit 3 1 22768210.0 593710.0 1741100.0 20433400.0 True False 768569.2987737412 1644206.2544500956 16714730.864389146 1.0 2.13930774631961 21.74785135323209 19.551815822173054 -6.918835526437521 0.8333263773946827 0.5489254593231155 24.826648013900417 0.9938511204753462 0.7467800052552787 0.0988616966008276 0.1092032030952954 0.6394911935274582 1.8947419953128157 1.205492391229381e-07 6.918835526437521 24.277722554577302 up TTK(ub)DIILPFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTKDIILPFR 10 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2;C9JJ47 E9PFW3 AP2M1 AP-2 complex subunit mu 1 9204500.0 3471800.0 2735800.0 2996900.0 True False 3361589.6093672393 3828219.207008526 2211921.9849271583 1.0 1.1388121846703119 0.6579988166204245 21.680712177101768 -6.829480473290801 1.3301525692153493 1.0742006972648241 0.6451903813322049 0.9048435558819614 0.062327019932925096 0.18145507810538491 0.6280608367579275 0.036791468255636485 0.08467275900487074 1.480878836910949e-07 6.829480473290801 -0.4290103159326193 TTK(ub)LQLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTKLQLSK 8 1 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 16352900.0 4761300.0 6442200.0 5149400.0 True False 6242110.408494793 5481048.871498925 4616589.484532703 1.0 0.8780762455018176 0.7395879249828802 22.57360244474522 -6.969466617337923 0.2706237808886262 1.034167922440285 0.5793294068196649 0.9999779150179239 0.0004999167962667585 0.07647615424333373 0.009647869517089182 0.0027043553728934183 0.012869152417529011 1.072836109737284e-07 6.969466617337923 -0.45483851562062017 TTK(ub)LQLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTKLQLSK 8 1 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 25558000.0 5892700.0 8017300.0 11648000.0 True False 5705639.464000902 11218649.699667191 8597039.367490234 1.0 1.9662388011808343 1.506761761189486 22.443957156073566 -10.202611854267614 4.869684752393981 0.9999035851295655 1.7365002811867973 0.7740501093678367 0.1875807160895151 0.00019637710538718297 3.2156468100506025e-05 0.18164780578501433 0.06054141578955772 6.271741439905907e-11 10.202611854267614 0.7365966960572319 TTK(ub)LQLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTKLQLSK 8 1 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 17878600.0 4860900.0 5463000.0 7554700.0 True False 7374340.679391168 4488084.967386179 6061510.233657358 1.0 0.608608303102796 0.8219731766118787 22.814082636842823 -10.085856543471557 5.117346852461148 1.000005976025649 0.7152907398566302 0.7036232619173285 0.0871058448575834 5.9391137861553995e-06 1.0607416825533788e-06 0.08434164199641904 0.028113290540542124 8.206225683206057e-11 10.085856543471557 -0.28471523616901884 TTK(ub)LQLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTKLQLSK 8 1 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 16422200.0 4761300.0 5853700.0 5807200.0 True False 6521681.279294435 5595064.178402703 4435658.963038218 1.0 0.8579174508521857 0.6801404075235798 22.63681250626811 -6.968095957886769 0.30021504313314773 1.0307538119107034 0.5017319492933966 0.9999634796778717 0.0007907496559753948 0.07692561281826389 0.011230483783804257 0.002946232667671013 0.0159403801859379 1.0762273936237994e-07 6.968095957886769 -0.5290218626173068 TTK(ub)LQLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTKLQLSK 8 1 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 25746200.0 5892700.0 13328000.0 6525500.0 True False 4900041.140872475 13256199.418599138 7889951.879496983 1.0 2.705324105960223 1.6101807418890652 22.224362431507842 -10.477026371162763 4.9700739070651725 0.9970866134433728 2.157752423924711 0.5984167674273064 0.44709040619512563 0.01445312726026391 0.0015208209674243103 0.4334957012633736 0.14429780812020288 3.334061671105419e-11 10.477026371162763 1.1606658104813379 TTK(ub)LQLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTKLQLSK 8 1 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 1 12495700.0 4860900.0 4062300.0 3572500.0 True False 6292530.872663887 3836229.4339513113 2922341.6569455024 1.0 0.6096480909798504 0.4644143534743366 22.585208958935272 -13.999999999999998 0.13730325039432048 2.8606853688981695 0.27870365703748207 0.999613900818652 0.004443830399451989 11.932233450167645 0.11589040537536922 5.9581888505607195 0.16574068096690256 1.0000000000000041e-14 13.999999999999998 -2.5819817118606876 TTLAHIIASNSK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTLAHIIASNSKK 13 1 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 43653500.0 16328000.0 19114000.0 8211500.0 True False 21406166.120576944 16262265.705788458 7361852.750269987 1.0 0.7597000609163802 0.3439127169621147 24.35152309402568 -6.962775823947466 0.3943692425962162 1.0243253161225219 0.06424271922253014 0.9998596981871551 0.0032102187264884297 0.07872407544337053 0.017573786063573092 0.00535738189618092 0.03491219614822942 1.0894923271960438e-07 6.962775823947466 -0.9600825968999918 down TTLAHIIASNSK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTLAHIIASNSKK 13 1 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 60413000.0 16071000.0 20587000.0 23755000.0 True False 15560834.901820626 28807496.459786735 17532852.86527567 1.0 1.8512821864343694 1.1267295730529419 23.891416133044785 -10.215156366184099 4.564418782250347 0.9998778667625816 1.4890058796455625 0.37785147377740047 0.29579736579845817 0.00038516647841856165 6.622828968496322e-05 0.2864789588714521 0.09546818929409635 6.093174751509356e-11 10.215156366184099 0.4891280128829809 TTLAHIIASNSK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTLAHIIASNSKK 13 1 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 38587000.0 16328000.0 11517000.0 10742000.0 True False 22364902.847608756 11008140.858374005 8204960.838434458 1.0 0.49220606650437515 0.3668677165441713 24.41473315554857 -13.999999999999998 0.19649030042679036 3.7859092563377006 0.28259337156848596 0.9994871282622521 0.006199382615534074 12.463705715477179 0.14056628487709286 13.325722211359055 0.08194922657739355 1.0000000000000041e-14 13.999999999999998 -3.5033158847692145 TTLAHIIASNSK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTLAHIIASNSKK 13 1 Q96S55-2;Q96S55;Q96S55-3 Q96S55-2 WRNIP1 ATPase WRNIP1 1 55260000.0 16071000.0 27102000.0 12087000.0 True False 13363748.566015825 26955996.146674223 14614335.816026345 1.0 2.017098422161552 1.0935805731328094 23.67182140847906 -6.6231447454368615 2.105199191316852 1.6733913690521953 1.0971726582122716 0.09339510684138685 0.43704084666649967 0.577093524077382 4.8643114848245155 0.17032399330419998 0.4844530025036675 2.3815256015359605e-07 6.6231447454368615 -0.5762187108399237 TTLALHHLSSGHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTLALHHLSSGHLK 14 0 Q8N766-3;Q8N766-2;Q8N766;Q8N766-4 Q8N766-3 EMC1 ER membrane protein complex subunit 1 0 5142100.0 1370000.0 1499800.0 2272300.0 False True 1796083.2670988722 1276035.68617461 2037184.19344072 1.0 0.7104546373485956 1.1342370539041247 20.77642280484085 -6.722765852635785 1.7492031886746542 0.8243670421445419 1.1336883170259462 0.52558684629034 0.12180241854014012 0.3499824431131193 2.094192687293848 0.05525627297078332 0.13827307333334599 1.893364139868257e-07 6.722765852635785 0.30932127488140426 TTLCVSILER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTLCVSILER 10 0 Q16401;Q16401-2 Q16401 PSMD5 26S proteasome non-ATPase regulatory subunit 5 0 49447000.0 12257000.0 23247000.0 13943000.0 False True 18594765.106728733 19098391.220359992 11187159.938566014 1.0 1.0270842955391255 0.6016295379024611 24.148393187827047 -6.89171522883526 1.0121484937214593 1.0219289925824317 0.5637781595740405 0.9819747248348518 0.026112156643088448 0.11776377192159126 0.21379131591684575 0.01961121224751749 0.0492044002240306 1.28317169516846e-07 6.89171522883526 -0.4581508330083912 TTLLNYILTEQHSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTLLNYILTEQHSK 14 0 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;Q9BRT8-2;A0A087X140;F2Z2T4;A0A087WTC0;A0A087WZQ3 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 0 69351100.0 6118100.0 23594000.0 39639000.0 False True 8380126.905435747 22551539.065075632 30277084.59083072 1.0 2.6910736936987956 3.6129625401247294 22.998540661035975 -8.826173651010453 0.23864655457857248 3.0320597987000478e-21 4.339691596264544 0.9993114152619006 0.028393549277581843 0.3468429836862979 0.07484741229723249 0.6830738624239594 0.3976725505517846 1.4921976406809143e-09 8.826173651010453 4.339691596264544 TTLLNYILTEQHSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTLLNYILTEQHSK 14 0 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;Q9BRT8-2;A0A087X140;F2Z2T4;A0A087WTC0;A0A087WZQ3 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 0 100327000.0 43366000.0 20501000.0 36460000.0 False True 36060750.439539686 20390557.043870095 44083617.42800706 1.0 0.5654501582837936 1.2224819752966234 25.103926084391027 -6.728384848643667 1.7294365155180866 0.738017448942318 1.2219548958695892 0.5516450680655661 0.18269827534397537 0.3392621187840529 1.987233481392752 0.08374739868420612 0.2081693913564759 1.8690251757322373e-07 6.728384848643667 0.48393744692727114 TTLLNYILTEQHSK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTLLNYILTEQHSKR 15 1 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;Q9BRT8-2;A0A087X140;F2Z2T4;A0A087WTC0;A0A087WZQ3 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 1 10112500.0 1369600.0 4247800.0 4495100.0 True False 1795558.8632252647 3614044.7977947155 4029990.172043912 1.0 2.0127687662118765 2.2444210850348063 20.776001518506742 -10.611260370939446 0.3028345032074523 1.2355544948365373e-11 2.3149801907522374 0.9991224768050662 0.01600723562057827 2.2304214142881116 0.14861553523507498 1.751841451053202 0.08211972360755478 2.4475954042060502e-11 10.611260370939446 2.314980190739882 TTLLNYILTEQHSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTLLNYILTEQHSKR 15 1 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;Q9BRT8-2;A0A087X140;F2Z2T4;A0A087WTC0;A0A087WZQ3 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 1 23735200.0 2463100.0 4822500.0 16449600.0 True False 2384910.238732773 6748149.399005276 12140956.282577915 1.0 2.829519236996911 5.090739301378922 21.185503537621194 -6.968274750899011 0.29651351062905673 0.5912197602363188 7.399542949581328 0.9999656243300374 0.009809713134533504 0.07686657955217696 0.011023287205225678 0.0381785795222358 0.20356093243443926 1.0757844169287378e-07 6.968274750899011 6.808323189345009 TTLLNYILTEQHSK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTLLNYILTEQHSKR 15 1 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;Q9BRT8-2;A0A087X140;F2Z2T4;A0A087WTC0;A0A087WZQ3 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 1 51647000.0 5591000.0 10115000.0 35941000.0 True False 8481955.756850805 8309899.221144275 28837245.596500117 1.0 0.9797149925513863 3.3998344748743254 23.015965526965147 -6.905010051165788 0.9290537133110609 0.91273812302687 3.6813754897417157 0.9888981436067051 0.11970601603284911 0.10781086214532284 0.15735305026057875 0.09564844980362064 0.2557370801479954 1.2444858094760285e-07 6.905010051165788 2.7686373667148456 up TTLLNYILTEQHSK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTLLNYILTEQHSKR 15 1 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;Q9BRT8-2;A0A087X140;F2Z2T4;A0A087WTC0;A0A087WZQ3 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 1 6295700.0 1369600.0 1558300.0 3367800.0 True False 1875978.1320483151 1489449.1533910052 2572395.0020182063 1.0 0.7939586970370106 1.3712286716314213 20.839211580029634 -6.810182608290198 1.4136306663180986 0.8877330524926578 1.3813833848435413 0.8603396667554433 0.08926626275868553 0.20654903499806995 0.81345524290341 0.0496507243159066 0.11485007472751338 1.548165523136497e-07 6.810182608290198 0.4936503323508835 TTLLNYILTEQHSK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTLLNYILTEQHSKR 15 1 Q8IUF1;C9J3G2;Q9BRT8;Q9BRT8-3;Q9BRT8-2;A0A087X140;F2Z2T4;A0A087WTC0;A0A087WZQ3 Q8IUF1;Q9BRT8 CBWD2;CBWD1 COBW domain-containing protein 2;COBW domain-containing protein 1 1 33973300.0 5591000.0 9460500.0 18921800.0 True False 7237659.715086474 8934014.858552128 15478226.55406339 1.0 1.2343789581499254 2.138567874612831 22.787091849057596 -6.9457067260108785 0.6041426197745241 0.9899012489069471 2.429661831971015 0.9988198414379011 0.0168640331067694 0.08525688639532683 0.043459888281209794 0.01723832596324021 0.07609004666138891 1.1331653182228472e-07 6.9457067260108785 1.4397605830640678 up TTLLPGLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTLLPGLLK 9 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 17993300.0 3532900.0 6179700.0 8280700.0 False True 4631666.112652271 5257712.8482819395 7423892.598083258 1.0 1.135166637750399 1.6028557364710492 22.14309982546163 -6.948207948714057 0.5781926172106407 0.9943708526442306 1.7667120660609161 0.9990529688240785 0.007948678083379306 0.08421361269523515 0.03900424486993041 0.008344517149489568 0.03904959245236401 1.1266578611248275e-07 6.948207948714057 0.7723412134166855 TTLLPGLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTLLPGLLK 9 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 16646500.0 5894600.0 3089500.0 7662400.0 False True 5707479.149540915 4323153.461529657 5655387.572927311 1.0 0.757454096328568 0.990873102599456 22.44442225335648 -10.661698160554327 8.65603496295463 1.0001484067781543 0.8741635994890825 0.279282602709519 0.09529291027186378 0.0002732394976291993 1.0678937015223576e-05 0.09237497723688284 0.030755654541213852 2.179223830700022e-11 10.661698160554327 -0.1259848072890718 TTLLPGLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTLLPGLLK 9 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 27573300.0 5756400.0 17596000.0 4220900.0 False True 8732879.649210513 14455856.321824484 3386637.264913806 1.0 1.6553367162378507 0.38780303873991573 23.058026027371167 -6.766177662544836 1.5890172583408722 1.3777138590233702 0.38166932396876474 0.7157549095935039 0.2759397046922363 0.2726542555275221 1.358042328231982 0.1369261658647865 0.3271063577365975 1.7132562998879438e-07 6.766177662544836 -0.9960445350546054 TTLLPGLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTLLPGLLK 9 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 17082400.0 3532900.0 5951400.0 7598100.0 False True 4839108.603032642 5688447.469352005 5803585.267781498 1.0 1.1755155620576665 1.1993087454463047 22.20630988698452 -13.370491890060624 0.2895514477469577 1.9776552774973667e-05 1.2059534064290285 0.9995923609402547 0.001794470731694232 11.14305870842377 0.1686637500260678 6.553727849741911 0.009008749285978406 4.260966403628101e-14 13.370491890060624 1.2059336298762535 TTLLPGLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTLLPGLLK 9 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 12180400.0 5894600.0 3119400.0 3166400.0 False True 4901621.075056751 3102595.173047577 3828479.60022056 1.0 0.6329732807858174 0.7810639667155899 22.224827528790755 -10.090265582763672 5.0782875552714515 1.0000070298658719 0.7070186247836519 0.8391949793056258 0.0604577693673532 4.812016533888633e-06 8.621416248326811e-07 0.058539387470462216 0.01951266115863435 8.123336003822645e-11 10.090265582763672 -0.29298840508222 TTLLPGLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTLLPGLLK 9 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 14383800.0 5756400.0 4480300.0 4147100.0 False True 7451773.275607902 4230967.366499775 3392370.352839383 1.0 0.5677799377430227 0.45524336656131553 22.829152349463616 -13.999999999999998 0.18891768623377636 3.3083626598910794 0.37362342276930494 0.9994900390207085 0.005302640295881318 12.333297194146391 0.13783374861963937 10.476312479976315 0.07806421549229847 1.0000000000000041e-14 13.999999999999998 -2.934739237121774 TTLPTFQSPEFSVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTLPTFQSPEFSVTR 15 0 Q9Y5X3;Q5QPE4 Q9Y5X3 SNX5 Sorting nexin-5 0 13671600.0 3406100.0 6014000.0 4251500.0 False True 4465430.084719316 5116734.6423883885 3811595.563267713 1.0 1.1458548326392646 0.8535786007065652 22.090367703508335 -6.771042566893927 1.5707093048604854 1.0835470494328219 0.8518787981983076 0.734458204191901 0.06148718194563457 0.26473981966452015 1.2891923027765226 0.030854894132242124 0.07337004387162054 1.6941717399376159e-07 6.771042566893927 -0.2316682512345143 TTLPTFQSPEFSVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTLPTFQSPEFSVTR 15 0 Q9Y5X3;Q5QPE4 Q9Y5X3 SNX5 Sorting nexin-5 0 16064400.0 4308600.0 2466500.0 9289300.0 False True 4171825.8514084015 3451386.312627582 6856153.656973476 1.0 0.8273083382573123 1.6434419607086066 21.992247504613935 -6.851416165337324 1.2282419803663653 0.9077226055358285 1.6769691898377066 0.9423407672424937 0.08432529121316991 0.15590571252346758 0.45188490848193774 0.053702612500029105 0.12438834266757198 1.407938985667831e-07 6.851416165337324 0.7692465843018781 TTLPTFQSPEFSVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTLPTFQSPEFSVTR 15 0 Q9Y5X3;Q5QPE4 Q9Y5X3 SNX5 Sorting nexin-5 0 13138600.0 3406100.0 3851400.0 5881100.0 False True 4665427.216391478 3681232.413123352 4492105.305056498 1.0 0.7890450847008688 0.9628497234452547 22.153577765031226 -10.031710601508445 5.771744439820897 1.0000003198062184 0.8759474041287275 0.40449498625797176 0.07095544664217988 2.920199232405492e-07 4.895484927986707e-08 0.06870249289883756 0.02290077193064212 9.295856234393267e-11 10.031710601508445 -0.12405291567749088 TTLTAAITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTLTAAITK 9 0 P49411;H3BNU3 P49411 TUFM Elongation factor Tu, mitochondrial 0 158242000.0 53336000.0 34178000.0 70728000.0 False True 69924012.5065587 29078775.624800548 63409745.03088288 1.0 0.41586251392642876 0.9068379052894769 26.059284638769988 -10.18237898713209 7.751166476731992 1.000000155680503 0.6613502096079599 0.3881315620370237 0.2004398641837905 5.390601016365443e-07 5.7084027372654185e-08 0.19407515073180284 0.06469168799165809 6.570841825006093e-11 10.18237898713209 -0.33864994607254306 TTLTAAITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTLTAAITK 9 0 P49411;H3BNU3 P49411 TUFM Elongation factor Tu, mitochondrial 0 75686700.0 30402000.0 9982700.0 35302000.0 False True 29436905.151213467 13968844.16909279 26055347.162700914 1.0 0.4745350809582969 0.8851252204964503 24.81112266584769 -9.877976021504557 6.559931800295462 1.0000000139630298 0.6798301507273591 0.4477401491501233 0.16762272254783273 3.427667971443128e-08 5.898741122826444e-09 0.16230001047376627 0.054100001072799296 1.3244146574549355e-10 9.877976021504557 -0.32016986323567076 TTLTAAITK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTLTAAITK 9 0 P49411;H3BNU3 P49411 TUFM Elongation factor Tu, mitochondrial 0 164519000.0 48721000.0 69058000.0 46740000.0 False True 73913318.98220846 56734060.347383335 37501818.51313027 1.0 0.7675756024572471 0.5073756533941773 26.13933102179286 -6.9696638273045055 0.266094418053456 1.0678242670503335 0.1993451601978837 0.9999796393888704 0.00090793938324034 0.07641193787194307 0.009419835539727667 0.005225293788706411 0.024332648606092796 1.072349053252956e-07 6.9696638273045055 -0.8684791068524498 TTLTAAITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTLTAAITK 9 0 P49411;H3BNU3 P49411 TUFM Elongation factor Tu, mitochondrial 0 107869000.0 53336000.0 22264000.0 32269000.0 False True 73055760.55120401 21280302.8627975 24647726.800916154 1.0 0.2912884993905766 0.3373823859330138 26.12249470029288 -9.869157801418663 6.772991309595891 1.0000000150289043 0.3143354426617783 0.996622035782852 0.018817750381846517 4.264077335602954e-09 7.21548376339207e-10 0.018220208731968997 0.00607340282015592 1.351581375255973e-10 9.869157801418663 -0.685664572367126 TTLTAAITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTLTAAITK 9 0 P49411;H3BNU3 P49411 TUFM Elongation factor Tu, mitochondrial 0 66939000.0 30402000.0 22320000.0 14217000.0 False True 25280610.036961854 22199757.72982686 17189708.96801908 1.0 0.8781337830601954 0.6799562567076758 24.591527941281967 -6.963880306453411 0.3767780745881129 1.0141157611482996 0.5370019374736865 0.9998881650505694 0.0013947471156139234 0.07834303578669778 0.0162126463478248 0.0025883019228971895 0.01677218422447418 1.0867250887556168e-07 6.963880306453411 -0.4771138236746131 TTLTAAITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTLTAAITK 9 0 P49411;H3BNU3 P49411 TUFM Elongation factor Tu, mitochondrial 0 155418000.0 48721000.0 68073000.0 38624000.0 False True 63070294.93448893 64284677.709023714 31594828.315706983 1.0 1.0192544331019249 0.5009462592259083 25.91045734388531 -6.898272521818406 0.9721358218046812 1.0225826275353693 0.4484122641626186 0.9856867489536691 0.028703943847404274 0.11268763279751766 0.18468311301543563 0.022215409400632043 0.05731495096037638 1.2639429684490335e-07 6.898272521818406 -0.5741703633727507 TTNFAGILSQGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTNFAGILSQGLR 13 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 173318000.0 44194000.0 57267000.0 71857000.0 False True 57938761.97530477 48722986.82501763 64421926.941015646 1.0 0.8409393843414332 1.1118968501341848 25.788025521909763 -6.747614317698223 1.6585629624264384 0.9062008610221763 1.1123413783373688 0.638624065657613 0.06683241508656523 0.3042571393946755 1.6459414810884225 0.031840937207269056 0.07749916463910762 1.7880747989718848e-07 6.747614317698223 0.20614051731519245 TTNFAGILSQGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTNFAGILSQGLR 13 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 140967000.0 43031000.0 30498000.0 67438000.0 False True 41665004.45897851 42676010.44496898 49773964.70336604 1.0 1.0242651116714956 1.1946228099500444 25.31233279870616 -6.932607762167476 0.7250569361110675 0.9976435455753447 1.2320394171762263 0.9970266040950234 0.004721934229378539 0.09130587817057921 0.07120851555322624 0.004370713808819693 0.015199398162670175 1.1678639100117383e-07 6.932607762167476 0.2343958716008816 TTNFAGILSQGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTNFAGILSQGLR 13 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 118634000.0 25672000.0 66040000.0 26922000.0 False True 38946300.87459732 54254646.02712496 21600854.899668243 1.0 1.3930628791119029 0.5546317471643982 25.21498297161769 -6.7792215836129435 1.5388925900864483 1.2227862139608225 0.5481497640351516 0.7646329014039894 0.1661675311546311 0.25178383833089163 1.1777001345329583 0.08505082591766516 0.20081613119265762 1.6625641685510067e-07 6.7792215836129435 -0.674636449925671 TTNFAGILSQGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTNFAGILSQGLR 13 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 192659000.0 44194000.0 53173000.0 95292000.0 False True 60533716.09794342 50823641.04040294 72785992.20034404 1.0 0.8395922853665617 1.2024041623774835 25.851235583432654 -6.786528586566727 1.5102605155774655 0.9099420761537362 1.2058979173581839 0.7898575774104126 0.06805035674968961 0.24056403318762978 1.084018053470374 0.035474614721783364 0.08326656983572968 1.6348255384628213e-07 6.786528586566727 0.2959558412044476 TTNFAGILSQGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTNFAGILSQGLR 13 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 105458000.0 43031000.0 24711000.0 37716000.0 False True 35782183.096523374 24577876.938250512 45602241.22091914 1.0 0.686874718402481 1.2744398824941983 25.092738074140435 -6.761924585971197 1.605114384308487 0.818554187688254 1.2768008421901436 0.6988017830750313 0.13174075807676505 0.2797043845572626 1.4206872512350854 0.06474349411393189 0.15530150199494536 1.73011676309583e-07 6.761924585971197 0.4582466545018895 TTNFAGILSQGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTNFAGILSQGLR 13 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 82308000.0 25672000.0 30608000.0 26028000.0 False True 33232910.070774414 28904637.893405594 21291171.069832783 1.0 0.8697594592784345 0.6406652629724594 24.98610929371014 -6.9624759348666405 0.399008972176008 1.0127320830666102 0.48934091853135553 0.9998512902213778 0.0018113449108431406 0.07882825588320601 0.017948251614735317 0.0029481899708756498 0.019201483359813285 1.0902449033808496e-07 6.9624759348666405 -0.5233911645352547 TTPDVIFVFGFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTPDVIFVFGFR 12 0 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4;A0A2R8Y8A0 E7ETK0 RPS24 40S ribosomal protein S24 0 648730000.0 183900000.0 229760000.0 235070000.0 False True 278989744.8908715 188757532.87692654 188608311.4651587 1.0 0.6765751656956429 0.6760403022660706 28.055636851522546 TTPDVIFVFGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTPDVIFVFGFR 12 0 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4;A0A2R8Y8A0 E7ETK0 RPS24 40S ribosomal protein S24 0 243479000.0 99508000.0 57841000.0 86130000.0 False True 82745310.95184527 57529399.05246046 104139384.779875 1.0 0.6952587208952596 1.258553307515882 26.302174223162293 -6.759742948712126 1.6131895230590276 0.8229389765566449 1.2606049494328093 0.6900535625496986 0.12817088567573526 0.2833282670473527 1.4531040073230925 0.06268697280025255 0.15069983865637968 1.7388297070426038e-07 6.759742948712126 0.4376659728761644 TTPDVIFVFGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTPDVIFVFGFR 12 0 E7ETK0;A0A2R8Y849;A0A2R8YD14;P62847-2;P62847-3;P62847;P62847-4;A0A2R8Y8A0 E7ETK0 RPS24 40S ribosomal protein S24 0 510220000.0 183900000.0 154920000.0 171400000.0 False True 238062175.21094656 146298565.81437516 140206958.71251476 1.0 0.6145393138777305 0.588951010752874 27.826763173614996 -13.999999999999996 0.38541485834592715 6.919013560018828 0.5869128727789942 0.9998161005758772 0.0025498530745242123 24.733067116362307 0.20300196668049772 121.73547440406631 0.006824730350807217 1.0000000000000082e-14 13.999999999999996 -6.332100687239834 TTPLK(ub)PSPLPVIPDTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTPLKPSPLPVIPDTIK 17 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 6168600.0 2407600.0 1472200.0 2288800.0 True False 3297754.782943582 1407153.336085631 1748232.579315659 1.0 0.42670041549590393 0.5301281309203904 21.653052695029817 -10.13847772922779 7.570216881457217 1.0000001568249641 0.4784142732084694 0.9713541740347948 0.042224188008629523 1.1176543291029462e-07 1.2674754177812804e-08 0.04088340612042645 0.013627798080379418 7.269796780292286e-11 10.13847772922779 -0.5215858836164947 TTPPSVFFPVFVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTPPSVFFPVFVR 13 0 C9IZY8;F8W1F5;Q8IVF7-2;Q8IVF7-3;Q8IVF7;Q96PY5;Q96PY5-3 C9IZY8 FMNL2;FMNL3 Formin-like protein 3;Formin-like protein 2 0 2173750.0 686210.0 524830.0 962710.0 False True 899627.9552670934 446527.4097713167 863098.0041664016 1.0 0.4963467477383423 0.9593943797690831 19.77896896692045 -10.492823812557662 9.063283641315936 1.0000068880117463 0.7278705637537128 0.3153073580665703 0.18903840417988985 2.6311220024234776e-05 1.472541027371459e-06 0.18304027529282366 0.06101188259852833 3.2149645420785216e-11 10.492823812557662 -0.27213632425803347 TTPPSVFFPVFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTPPSVFFPVFVR 13 0 C9IZY8;F8W1F5;Q8IVF7-2;Q8IVF7-3;Q8IVF7;Q96PY5;Q96PY5-3 C9IZY8 FMNL2;FMNL3 Formin-like protein 3;Formin-like protein 2 0 2659820.0 686210.0 884310.0 1089300.0 False True 939920.3811279765 845238.2601778868 832029.7748377069 1.0 0.899265807135213 0.8852130367033934 19.84217902844334 -13.999999997314019 0.27749292723083513 1.809746619812145 0.8808769672499618 0.9995996313155953 0.0010228899080357238 15.264169395529489 0.16683563663369375 7.0040418310566395 0.005625856826785999 1.0000000061847003e-14 13.999999997314019 -0.9288696525621832 TTPSVVAFTADGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTPSVVAFTADGER 14 0 P38646;A0A3B3ITI4;D6RJI2;D6RA73 P38646 HSPA9 Stress-70 protein, mitochondrial 0 42349800.0 8996800.0 15315000.0 18038000.0 False True 11794891.925135124 13030061.697402442 16171600.792713882 1.0 1.1047207367483503 1.3710681619940843 23.4916588636464 -6.955091799173902 0.499831582401381 0.9946580940339882 1.4926152629871126 0.9995426425037928 0.0033405743468941083 0.08150332486495919 0.027982426812817252 0.003918873382260169 0.021971122291149333 1.1089403877587341e-07 6.955091799173902 0.49795716895312436 TTPSVVAFTADGER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTPSVVAFTADGER 14 0 P38646;A0A3B3ITI4;D6RJI2;D6RA73 P38646 HSPA9 Stress-70 protein, mitochondrial 0 42377200.0 12037000.0 9478200.0 20862000.0 False True 11654892.023720672 13262894.688160047 15397616.353415305 1.0 1.1379680447632359 1.3211290436734409 23.474432302949932 -6.967207088821197 0.31790166268327313 0.9742904162589187 1.4906962515550675 0.9999516780697622 0.0009143159308620541 0.07721977650677986 0.012259711925705363 0.0028003588589415877 0.016141486503735657 1.0784323603150107e-07 6.967207088821197 0.5164058352961488 TTPSVVAFTADGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTPSVVAFTADGER 14 0 P38646;A0A3B3ITI4;D6RJI2;D6RA73 P38646 HSPA9 Stress-70 protein, mitochondrial 0 110388000.0 14640000.0 75630000.0 20118000.0 False True 22209950.327364665 62133235.60011295 16141668.481967367 1.0 2.7975405025358926 0.7267764332673619 24.40470283050729 -6.677197534402095 1.9120842984128719 2.1401798451757017 0.7348633844482686 0.3112761498927874 0.7623120667422492 0.44475790340783194 3.1414167727764473 0.32021236421999016 0.847508550330554 2.1028217752466355e-07 6.677197534402095 -1.405316460727433 TTPSVVAFTADGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTPSVVAFTADGER 14 0 P38646;A0A3B3ITI4;D6RJI2;D6RA73 P38646 HSPA9 Stress-70 protein, mitochondrial 0 38174800.0 8996800.0 14824000.0 14354000.0 False True 12323160.08937813 14169026.66358742 10963880.829909539 1.0 1.1497884114806172 0.8896971840331594 23.55486892516929 -6.7505060218216935 1.647734391782268 1.0880207662014285 0.8891521415293792 0.6512752858478279 0.06294385064618595 0.2991466941324129 1.5981005392180638 0.03017323753375541 0.07322041534203892 1.776208639640554e-07 6.7505060218216935 -0.19886862467204935 TTPSVVAFTADGER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTPSVVAFTADGER 14 0 P38646;A0A3B3ITI4;D6RJI2;D6RA73 P38646 HSPA9 Stress-70 protein, mitochondrial 0 28086100.0 12037000.0 9789300.0 6259800.0 False True 10009298.82951481 9736563.097876094 7568695.237954971 1.0 0.9727517645057724 0.7561663775725093 23.25483757838421 -6.930215787404233 0.7450173000741126 1.0032673827987033 0.711456987804878 0.9965804980785815 0.00637922575951037 0.09252597408490862 0.07713204475844428 0.005819254342612906 0.0195740481307567 1.1743139299350573e-07 6.930215787404233 -0.29181039499382533 TTPSVVAFTADGER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTPSVVAFTADGER 14 0 P38646;A0A3B3ITI4;D6RJI2;D6RA73 P38646 HSPA9 Stress-70 protein, mitochondrial 0 48110000.0 14640000.0 15877000.0 17593000.0 False True 18951768.597543556 14993430.992995314 14391254.519424018 1.0 0.7911362422892129 0.7593620851454121 24.17582915259974 -13.999999999999678 0.2651136235471541 2.570623303473033 0.74830533763075 0.9995729313267406 0.0022058366571722056 14.649267423386622 0.16295848421771175 12.364510565642231 0.013526881252619544 1.0000000000007403e-14 13.999999999999678 -1.8223179658422828 TTPSYVAFTDTER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTPSYVAFTDTER 13 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PI65;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;Q53FA3;P34931;P17066;P48741 P11142;P0DMV9;Q53FA3;P17066 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA1L;HSPA6;HSPA7 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 564900000.0 101600000.0 197990000.0 265310000.0 False True 133198583.89579943 168450663.75897533 237858266.23322535 1.0 1.2646580679172492 1.785741704426082 26.98900350353985 -6.960350235231559 0.4304689140232724 0.9794044112330702 2.0909935585358737 0.9997829700357997 0.004808825277210401 0.07957623684676238 0.020670744144388423 0.006797877192851715 0.04326137771282341 1.095594301678426e-07 6.960350235231559 1.1115891473028034 TTPSYVAFTDTER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTPSYVAFTDTER 13 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PI65;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;Q53FA3;P34931;P17066;P48741 P11142;P0DMV9;Q53FA3;P17066 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA1L;HSPA6;HSPA7 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 439237000.0 145810000.0 97727000.0 195700000.0 False True 141181341.3623588 136749900.73957247 144440299.12584472 1.0 0.9686117118592001 1.0230834877473036 27.072974192589605 -6.750456693701591 1.6482330688648568 0.9815535166782214 1.0231950433657586 0.6509118422089958 0.013189837040195367 0.2992444018596136 1.5996302900482537 0.006321305420253687 0.01533859863428983 1.7764103967726616e-07 6.750456693701591 0.04164152668753718 TTPSYVAFTDTER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTPSYVAFTDTER 13 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PI65;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;Q53FA3;P34931;P17066;P48741 P11142;P0DMV9;Q53FA3;P17066 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA1L;HSPA6;HSPA7 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 1590870000.0 214070000.0 1175300000.0 201500000.0 False True 324759840.61331594 965558532.3391869 161673436.6794126 1.0 2.9731463425887537 0.49782459670533413 28.274798000827282 -6.694368916221342 1.8506511578906788 2.231961479389822 0.5058633454271582 0.3909349343373264 0.8337829028582565 0.40741401131595356 2.7085544124289544 0.3599530403276978 0.9322966266263547 2.021301432482753e-07 6.694368916221342 -1.726098133962664 TTPSYVAFTDTER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTPSYVAFTDTER 13 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PI65;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;Q53FA3;P34931;P17066;P48741 P11142;P0DMV9;Q53FA3;P17066 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA1L;HSPA6;HSPA7 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 566640000.0 101600000.0 236780000.0 228260000.0 False True 139164265.6367617 226318276.67324832 174349689.1622647 1.0 1.6262671716600787 1.2528337527202702 27.05221356506274 -10.230785405977342 4.833975413856647 0.9999159392185211 1.439550462190892 0.6487861080780564 0.15245355488720677 0.00013815622123321378 2.198445822189588e-05 0.1476406225708447 0.04920417326193547 5.877797150859495e-11 10.230785405977342 0.43963452297237104 TTPSYVAFTDTER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTPSYVAFTDTER 13 0 P11142;E9PKE3;E9PNE6;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PI65;P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;Q53FA3;P34931;P17066;P48741 P11142;P0DMV9;Q53FA3;P17066 HSPA8;HSPA2;HSPA1B;HSPA1A;HSPA1L;HSPA6;HSPA7 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2;Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like;Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 738510000.0 214070000.0 291110000.0 233330000.0 False True 277117834.9505561 274909472.59374386 190866334.16797605 1.0 0.9920309627231092 0.6887551434646233 28.04592432291973 -6.912536803070514 0.8782679245885063 1.008653550947626 0.6473563965769125 0.9918444766243354 0.013083852704347181 0.10276469945078821 0.1298398472517816 0.010848126038535083 0.030499729981446393 1.2231034661776688e-07 6.912536803070514 -0.3612971543707135 TTQFSCTLGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTQFSCTLGEK 11 0 Q01469;I6L8B7 Q01469 FABP5 Fatty acid-binding protein, epidermal 0 10680100.0 3948500.0 6731600.0 0.0 False True 5176521.737328392 5727271.519571282 0.0 1.0 1.1063937930118946 0.0 22.30355160201832 -6.95689911098212 1.1918743948525867 1.0617367354520442 9.755772808334131e-20 0.9740308788659078 0.08031332443483288 0.10487713610184322 0.2955645623313117 0.05615090088335241 0.10611321157903814 1.1043351332851728e-07 6.95689911098212 -1.0617367354520442 down TTQFSCTLGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTQFSCTLGEK 11 0 Q01469;I6L8B7 Q01469 FABP5 Fatty acid-binding protein, epidermal 0 8402000.0 3948500.0 4453500.0 0.0 False True 5408367.154200337 4256729.644244913 0.0 1.0 0.787063733448455 0.0 22.36676166354121 -7.271269312953236 0.8378829179502594 0.9890495516706177 2.1720854404141537e-17 0.9885889006095252 0.045943595222488594 0.10077917925423226 0.1377187130088268 0.039031045141652274 0.06886444790844436 5.3546450443520235e-08 7.271269312953236 -0.9890495516706177 down TTQIINITMTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTQIINITMTK 11 0 Q14980;Q14980-2;A0A087WY61;Q14980-5;H0YFY6 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 0 20289500.0 6952000.0 6418900.0 6918600.0 False True 9114139.323263757 5461225.1406762265 6202729.639897443 1.0 0.5992036051869977 0.6805612049472443 23.119674993807358 -10.108707126285024 5.312128405254836 1.0000066340991014 0.6398824050668632 0.9631315844030367 0.0332141010192878 2.6096501993636012e-06 4.378554122825168e-07 0.03216000736262328 0.010719805008779336 7.785614098962514e-11 10.108707126285024 -0.3601242290322382 TTQIINITMTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTQIINITMTK 11 0 Q14980;Q14980-2;A0A087WY61;Q14980-5;H0YFY6 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 0 19381100.0 4853800.0 3743300.0 10784000.0 False True 4699718.775835793 5238019.211051614 7959346.886934651 1.0 1.1145388609172875 1.693579396252102 22.164142999977066 -6.939560186476617 0.6636477588189795 0.9934487261019079 1.8477257736388577 0.9981056618098644 0.01321310987825225 0.08796793002172539 0.055528778023824304 0.012819477235618874 0.04993423521606091 1.1493169548856467e-07 6.939560186476617 0.8542770475369498 TTQIINITMTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTQIINITMTK 11 0 Q14980;Q14980-2;A0A087WY61;Q14980-5;H0YFY6 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 0 21878400.0 6224800.0 9515500.0 6138100.0 False True 9443476.693837382 7817384.680059171 4924901.844575196 1.0 0.8278079073526634 0.5215136336164291 23.170886666786167 -6.962270677529941 0.40215456616944484 1.0164424331283384 0.32165609680575125 0.9998453639449443 0.0024607099917422783 0.07889975024730761 0.018205923893052454 0.003940392236251653 0.02564213287725341 1.0907602994192244e-07 6.962270677529941 -0.6947863363225871 TTQIINITMTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTQIINITMTK 11 0 Q14980;Q14980-2;A0A087WY61;Q14980-5;H0YFY6 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 0 22798500.0 6952000.0 6580300.0 9266200.0 False True 9522342.270735899 6289560.587857821 7077714.403379385 1.0 0.6605056202597258 0.7432745223967265 23.18288505533025 -10.003718403680887 5.703165039742362 1.0000006200376357 0.7018900713280988 0.9453446172667321 0.03379026280145606 2.664078522794868e-07 4.654586112411258e-08 0.03271734928098007 0.010905760424434715 9.9147460814592e-11 10.003718403680887 -0.2981105487095369 TTQIINITMTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTQIINITMTK 11 0 Q14980;Q14980-2;A0A087WY61;Q14980-5;H0YFY6 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 0 11468500.0 4853800.0 3026700.0 3588000.0 False True 4036149.7597988723 3010394.566347091 4338234.210962407 1.0 0.7458579947482186 1.0748447082346588 21.944548275411343 -6.700416037744553 1.8292655435256846 0.8422527297389485 1.0738773214886568 0.4195870300334148 0.10726836958783313 0.3946687957014418 2.567786923539951 0.046775477939362084 0.12023782187818217 1.9933518441007526e-07 6.700416037744553 0.2316245917497083 TTQIINITMTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTQIINITMTK 11 0 Q14980;Q14980-2;A0A087WY61;Q14980-5;H0YFY6 Q14980 NUMA1 Nuclear mitotic apparatus protein 1 0 18038500.0 6224800.0 7855400.0 3958300.0 False True 8058126.309152246 7418240.084548433 3237930.01558779 1.0 0.9205911895576713 0.40182170040077664 22.942012988878616 -6.934061931914475 0.7126613674275328 1.0068255959863444 0.28339701685114255 0.997278082973321 0.013838912765927282 0.09058288328503704 0.0677452392241533 0.012927731707771572 0.04593651449958226 1.1639600327968349e-07 6.934061931914475 -0.7234285791352018 down TTQIPQWCVEYMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTQIPQWCVEYMR 13 0 O43143 O43143 DHX15 Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX15 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 TTQSGQMSGEGK(ub)AGPPGGSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTQSGQMSGEGKAGPPGGSSR 21 1 Q16630;Q16630-2 Q16630 CPSF6 Cleavage and polyadenylation specificity factor subunit 6 1 3981380.0 1911300.0 1471400.0 598680.0 True False 1850626.827692726 2058937.6932496324 441867.74798498134 1.0 1.1125623288497437 0.23876653108713503 20.819582579543987 -6.874533414055735 1.1098887939335156 1.0657825051086682 0.18299560805210877 0.9689994082450952 0.06833450466242277 0.13257981083308154 0.3025187042297165 0.0476399719085465 0.11376115955093205 1.3349548759095298e-07 6.874533414055735 -0.8827868970565594 down TTQSGQMSGEGK(ub)AGPPGGSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTQSGQMSGEGKAGPPGGSSR 21 1 Q16630;Q16630-2 Q16630 CPSF6 Cleavage and polyadenylation specificity factor subunit 6 1 7288110.0 2774000.0 3949500.0 564610.0 True False 2306703.9090366457 3928223.259585628 682667.3405383173 1.0 1.7029594670545216 0.2959492711066768 21.13740139936187 -6.7708738775592465 1.5712229414912489 1.4027475387979258 0.28779366504260384 0.7338600774222575 0.29633071981675435 0.26501441683478266 1.2913289269159842 0.14865111460221533 0.35355192009766767 1.694829920563867e-07 6.7708738775592465 -1.114953873755322 TTQSGQMSGEGK(ub)AGPPGGSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTQSGQMSGEGKAGPPGGSSR 21 1 Q16630;Q16630-2 Q16630 CPSF6 Cleavage and polyadenylation specificity factor subunit 6 1 2233200.0 1140400.0 1092800.0 0.0 True False 1476270.2806447165 1031984.7193515947 0.0 1.0 0.6990486314612433 0.0 20.493525448478923 -7.430589106703705 0.7461065101785501 0.9911171866188107 8.685124024536256e-18 0.9873012442354817 0.04720450995604929 0.11531317684192481 0.13989616870679136 0.04110363289694726 0.07390706253341658 3.7103159499039585e-08 7.430589106703705 -0.9911171866188107 down TTQVPQFILDDFIQNDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTQVPQFILDDFIQNDR 17 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 3856300.0 1101700.0 1644100.0 1110500.0 False True 1444339.3688779776 1398806.6886516039 995596.1126681869 1.0 0.9684750819596191 0.6893089907544423 20.46197833389879 -6.928256729476368 0.7609652749153636 1.0045311983761098 0.6344615156810223 0.9961843853280821 0.008624730787129387 0.0935532407841325 0.08218915930260409 0.007777551099233903 0.025506162151003372 1.1796231053715919e-07 6.928256729476368 -0.37006968269508755 TTQVPQFILDDFIQNDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTQVPQFILDDFIQNDR 17 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 12098500.0 3288500.0 4150700.0 4659300.0 False True 3184108.367533889 5808096.15561455 3438889.5539961657 1.0 1.8240887197293965 1.0800164934900147 21.602458006538416 -10.39377501188035 6.06186251660848 0.9999044267299535 1.4520526066097057 0.3298204986500701 0.30376621434386886 0.0003924415345829796 3.9246574982130705e-05 0.2941820265380721 0.09804012410785634 4.0385455736981416e-11 10.39377501188035 0.4521481798797522 TTQVPQFILDDFIQNDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTQVPQFILDDFIQNDR 17 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 5033100.0 1101700.0 1325500.0 2605900.0 False True 1509028.2623230382 1266935.0271576568 1990440.0901951538 1.0 0.8395701119654998 1.319021081242718 20.525188395421683 -6.816473414147113 1.3869018558231927 0.9132030456649484 1.328728535421989 0.8760846378172057 0.07014710327613667 0.1981262663731496 0.749736617156736 0.03975290868217597 0.09172846068249882 1.5259018018408465e-07 6.816473414147113 0.41552548975704073 TTQVPQFILDDFIQNDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTQVPQFILDDFIQNDR 17 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 9679900.0 3288500.0 3063900.0 3327500.0 False True 2734533.4552512625 3047394.1625634637 4023264.865378312 1.0 1.1144110000597722 1.471280176752723 21.382863281972693 -6.950571441153948 0.5525326818869971 0.9951370925434799 1.6073923259563954 0.9992453794979091 0.005513495905858442 0.08325704956170911 0.03501871985731524 0.005964931732838185 0.02961975384994315 1.1205430823817194e-07 6.950571441153948 0.6122552334129154 TTSCQHLVQYLATIAGISGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTSCQHLVQYLATIAGISGNK 21 0 A0A0D9SFK2;Q92614-2;Q92614-3;Q92614-4;Q92614;Q92614-5 A0A0D9SFK2 MYO18A Unconventional myosin-XVIIIa 0 8444300.0 3581400.0 2784600.0 2078300.0 False True 4695250.082326937 2369148.5342857833 1863257.4524613179 1.0 0.5045840994078953 0.39683880939051047 22.162770571276557 -13.999999999999984 0.21440155416440007 3.9182777601309726 0.336020210374471 0.999492935051672 0.0059143015079082505 12.853316119094844 0.14672986449069764 15.835226461139579 0.061910236242871605 1.0000000000000368e-14 13.999999999999984 -3.5822575497565015 TTSCQHLVQYLATIAGISGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTSCQHLVQYLATIAGISGNK 21 0 A0A0D9SFK2;Q92614-2;Q92614-3;Q92614-4;Q92614;Q92614-5 A0A0D9SFK2 MYO18A Unconventional myosin-XVIIIa 0 11245300.0 4347900.0 4562200.0 2335200.0 False True 4209878.294420139 6383910.251558709 1723541.0655016492 1.0 1.5164120682586186 0.40940401241196606 22.00534709559102 -6.779847487415564 1.5364049426223185 1.2924614786276891 0.40066698190259387 0.7668744302135648 0.21837097789024698 0.250808895319991 1.1693841272360144 0.11194550507165761 0.2641846910934059 1.6601698122324745e-07 6.779847487415564 -0.8917944967250953 down TTSCQHLVQYLATIAGISGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTSCQHLVQYLATIAGISGNK 21 0 A0A0D9SFK2;Q92614-2;Q92614-3;Q92614-4;Q92614;Q92614-5 A0A0D9SFK2 MYO18A Unconventional myosin-XVIIIa 0 24383200.0 3581400.0 2741800.0 18060000.0 False True 4905540.363695857 2620658.2100798707 13794599.957375366 1.0 0.5342241661029682 2.8120449399344967 22.22598063279945 -6.853428572748211 1.218428954210405 0.7505179384094396 2.9093131564855783 0.9451527785974216 0.23011185668974432 0.15371995993660817 0.4374280161741529 0.14764302116160252 0.3424898922731143 1.401430055439732e-07 6.853428572748211 2.158795218076139 up TTSCQHLVQYLATIAGISGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTSCQHLVQYLATIAGISGNK 21 0 A0A0D9SFK2;Q92614-2;Q92614-3;Q92614-4;Q92614;Q92614-5 A0A0D9SFK2 MYO18A Unconventional myosin-XVIIIa 0 15810100.0 4347900.0 2309600.0 9152600.0 False True 3615471.4946288555 2297157.726380293 11066366.34315901 1.0 0.6353687837929162 3.0608362863873233 21.785752371025296 -6.868619309954422 1.1414580135760062 0.7954272522724536 3.199155203549681 0.9632812987947507 0.2046243617449687 0.1381811318782741 0.33736732512341294 0.13924453052456878 0.32887996632767236 1.353258270698549e-07 6.868619309954422 2.403727951277227 up TTSFK(ub)GTSPSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTSFKGTSPSSK 12 1 Q9H3F6;F5GWA4;Q9H3F6-2;F5H6V0;F5H497;F8W8I7 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 81286100.0 15104100.0 34095000.0 32087000.0 True False 19801621.368312463 29008158.90126911 28766945.040237796 1.0 1.464938570519756 1.4527570497975528 24.239115228064712 -10.18016827442634 5.026619979282839 0.999965272452661 1.4588478101592413 0.9994716788080715 0.004973085012149043 1.935629880640123e-06 3.1569588115618577e-07 0.004815532513742256 0.0016050562856490043 6.604375012259951e-11 10.18016827442634 0.4588825377065803 TTSFK(ub)GTSPSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTSFKGTSPSSK 12 1 Q9H3F6;F5GWA4;Q9H3F6-2;F5H6V0;F5H497;F8W8I7 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 109719400.0 24030400.0 44110000.0 41579000.0 True False 23267568.105575938 61723353.03061126 30688212.556737397 1.0 2.6527633979856975 1.3189265168362458 24.471817094320073 -6.59281324721314 2.217447164991144 2.11661342491537 1.3228748058768622 0.0005907001074806351 0.715676619764417 0.6613914641020451 6.134825382609878 0.2689518416577881 0.7974883016130258 2.553799236473242e-07 6.59281324721314 -0.7937386190385078 TTSFK(ub)GTSPSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTSFKGTSPSSK 12 1 Q9H3F6;F5GWA4;Q9H3F6-2;F5H6V0;F5H497;F8W8I7 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 52105100.0 17462800.0 13205200.0 21437100.0 True False 26492344.301687382 10848628.88730149 17200047.788785286 1.0 0.4095005245198518 0.6492459705685525 24.65907217733293 -10.28960992847175 5.682000097217967 1.0000432753067738 0.5293732475442066 0.8370795789802349 0.09787566849589717 5.36609153581315e-05 6.709062798233111e-06 0.0947763910912574 0.031589236173624566 5.133222291091334e-11 10.28960992847175 -0.4706700277625673 TTSFK(ub)GTSPSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTSFKGTSPSSK 12 1 Q9H3F6;F5GWA4;Q9H3F6-2;F5H6V0;F5H497;F8W8I7 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 77494600.0 15104100.0 28068500.0 34322000.0 True False 20688493.942954868 26828340.859882835 26215850.483778417 1.0 1.2967759245239208 1.2671705613789157 24.302325289587603 -10.073153505902903 4.577985665552014 0.9999842360613606 1.2819732429168085 0.9918000635985426 0.012086338931347631 1.9875369801942513e-06 4.0236654849114755e-07 0.0117032156007552 0.0039008491109889113 8.449801253543525e-11 10.073153505902903 0.2819890068554479 TTSFK(ub)GTSPSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTSFKGTSPSSK 12 1 Q9H3F6;F5GWA4;Q9H3F6-2;F5H6V0;F5H497;F8W8I7 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 89401700.0 24030400.0 48360000.0 17011300.0 True False 19982342.327222146 48099475.08129155 20568284.178635634 1.0 2.4070989423379636 1.0293229813511529 24.25222236975435 -6.641299552669411 2.0398281867544537 1.9192684159098679 1.0350770980502693 0.15954670298068097 0.6018641055398972 0.5301299843116949 4.217412774520361 0.2401490418105082 0.6664419264748813 2.2840228654210523e-07 6.641299552669411 -0.8841913178595986 TTSFK(ub)GTSPSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTSFKGTSPSSK 12 1 Q9H3F6;F5GWA4;Q9H3F6-2;F5H6V0;F5H497;F8W8I7 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 36632200.0 17462800.0 10132300.0 9037100.0 True False 22605938.843250223 9568428.59799248 7392440.528476477 1.0 0.4232705690455967 0.32701320567731 24.43019849942538 -13.999999999999995 0.2519153014808308 5.049922113043269 0.2890087051456031 0.9995463214619579 0.00632965219559147 14.074721243334213 0.15881976774701595 28.877602791607952 0.043954145918178734 1.0000000000000123e-14 13.999999999999995 -4.760913407897666 TTSILCLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTSILCLAR 9 0 P35250;P35250-2 P35250 RFC2 Replication factor C subunit 2 0 11690200.0 3650700.0 3374400.0 4665100.0 False True 4786103.053429091 2870952.6733081783 4182400.202799066 1.0 0.5998518296114063 0.8738633824030405 22.190420030360734 -10.099174398357574 5.322678565555303 1.0000042207118172 0.7368576060070177 0.5514997501788361 0.11186474799525417 5.602917020840649e-06 9.482231765495481e-07 0.10831431287283506 0.03610419216767165 7.958397032331449e-11 10.099174398357574 -0.2631466147047995 TTSILCLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTSILCLAR 9 0 P35250;P35250-2 P35250 RFC2 Replication factor C subunit 2 0 12678800.0 3650700.0 2984600.0 6043500.0 False True 5000462.44645794 2852730.503247643 4616149.769789481 1.0 0.5704933361250147 0.9231445729703087 22.253630091883625 -9.976362926900917 6.866412698650721 1.0000000236982671 0.7468189545476611 0.4073171250410712 0.14396926457206088 5.2260925408187414e-08 7.865368220279376e-09 0.13939765347643018 0.046465880337776364 1.0559347273583132e-10 9.976362926900917 -0.253181069150606 TTSPGLFFSLFSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTSPGLFFSLFSR 13 0 O95466;O95466-2;O95466-3;K7EK60;K7EJE6 O95466 FMNL1 Formin-like protein 1 0 155568000.0 51906000.0 44487000.0 59175000.0 False True 78745196.83689809 36547947.27148253 47479035.31267613 1.0 0.46412922615690316 0.6029451600840828 26.230688591382307 -10.29575668614532 8.510900438597284 1.0000004732300258 0.5335371931205645 0.9377159066380651 0.05667136771491566 5.089024680830614e-07 4.207934030221014e-08 0.054871871437403776 0.018290605280555424 5.061081301015408e-11 10.29575668614532 -0.46646328010946136 TTSPGLFFSLFSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTSPGLFFSLFSR 13 0 O95466;O95466-2;O95466-3;K7EK60;K7EJE6 O95466 FMNL1 Formin-like protein 1 0 116391000.0 51906000.0 32889000.0 31596000.0 False True 67193340.22022499 31058698.23824548 25845852.202337325 1.0 0.462228818160418 0.38464901607254526 26.001814913474757 -13.999999999999998 0.2726955063983628 5.2114453426876 0.35956276429878276 0.9995891522165773 0.005546360698911053 15.01690102156938 0.16533302346873072 35.11726374463267 0.03179224956151226 1.0000000000000041e-14 13.999999999999998 -4.8518825783888175 TTSSAIYMNLASHIQPGTVNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTSSAIYMNLASHIQPGTVNR 21 0 A0A0U1RRM1;Q8WXI9;A0A0U1RR30 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 0 11611300.0 4055900.0 3279800.0 4275600.0 False True 3927147.674587417 4589441.243931047 3155692.0947494204 1.0 1.1686449362801743 0.8035582963100452 21.905050418764485 -6.781074386564502 1.5314502932418892 1.095356093401108 0.8005557205165099 0.7712634438013435 0.07135218764198663 0.24890102106555773 1.1530617544372537 0.03669199868506973 0.08650877349997498 1.6554863851676837e-07 6.781074386564502 -0.29480037288459804 TTSSAIYMNLASHIQPGTVNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTSSAIYMNLASHIQPGTVNR 21 0 A0A0U1RRM1;Q8WXI9;A0A0U1RR30 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 0 9529100.0 4055900.0 2917100.0 2556100.0 False True 3372660.556835522 2901385.003300985 3090568.691928932 1.0 0.8602659397254249 0.9163592480912846 21.68545569419876 -10.91456279760488 10.06112965469055 1.015431545867986 0.8883125939083548 0.8409156593942753 0.02289999724682452 0.008006038728703058 6.798567226546969e-05 0.02239469729155281 0.00739094233042892 1.217410946355403e-11 10.91456279760488 -0.12711895195963108 TTSSAIYMNLASHIQPGTVNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTSSAIYMNLASHIQPGTVNR 21 0 A0A0U1RRM1;Q8WXI9;A0A0U1RR30 A0A0U1RRM1 GATAD2B Transcriptional repressor p66-beta 0 22235100.0 4640800.0 9992500.0 7601800.0 False True 6007607.083844261 9436408.590886561 6218350.401054818 1.0 1.5707433024811293 1.0350794108651498 22.518359028526874 -10.37843067526289 3.417806988822422 0.997735119372493 1.3029113566135528 0.2989188879005038 0.21868386901254516 47543355.2430217 60802565.85607918 1042602.7385042219 0.08619923050559113 4.1837846744722885e-11 10.37843067526289 0.3051762372410598 TTSSANNPNLMYQDECDRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTSSANNPNLMYQDECDRR 19 1 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 12665200.0 1635000.0 5141800.0 5888400.0 False True 2143500.8333625253 4374663.482579425 5279124.853521253 1.0 2.0408965625251745 2.462851784965183 21.031537547378406 -9.920929041570975 0.2260025992916658 2.0361782284545002e-17 2.7617337914008226 0.9992495759447829 0.01684084818382974 1.3885140630262858 0.10096564845853524 1.0964560305098159 0.21486658390695623 1.199695302738222e-10 9.920929041570975 2.7617337914008226 TTSSANNPNLMYQDECDRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTSSANNPNLMYQDECDRR 19 1 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 9423600.0 3329400.0 1766400.0 4327800.0 False True 3223710.0194214205 2471732.7316543097 3194219.3487829873 1.0 0.7667354435613681 0.9908519468374125 21.620290545088917 -10.64988206497803 8.527732795783564 1.0001252601750392 0.8787936952198695 0.28056479130711154 0.09149517932718387 0.00021811866556332364 8.955173852771732e-06 0.08868084649703374 0.02952994214937034 2.2393291579870385e-11 10.64988206497803 -0.12133156495516972 TTSSANNPNLMYQDECDRR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTSSANNPNLMYQDECDRR 19 1 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 13753300.0 1635000.0 5583900.0 6534400.0 False True 2239503.6842136406 5337184.834511988 4991109.300192343 1.0 2.3831998456327788 2.2286675996002554 21.094747608901297 -10.07464294101181 4.479797226351252 0.9999080094033355 2.305933722678163 0.9896074958280303 0.06308752554078335 10951029.510433342 2.015132694262519 10554.529258675395 0.021596537981215438 8.420871864303433e-11 10.07464294101181 1.3060257132748276 TTSSANNPNLMYQDECDRR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTSSANNPNLMYQDECDRR 19 1 A0A1X7SBZ2;A0A5H1ZRQ2;Q92841;Q92841-1;Q92841-3;Q92841-2 A0A1X7SBZ2 DDX17 Probable ATP-dependent RNA helicase DDX17 0 5806670.0 3329400.0 1501800.0 975470.0 False True 2768543.617428482 1493709.5053160384 1179436.2669363134 1.0 0.5395289768645389 0.4260132509784383 21.400695820523193 -13.999999999997078 0.1966673482734511 3.5279316055835537 0.34982205225724516 0.9994871012263719 0.005620800754519285 12.466954585599664 0.14062871659521423 12.106639955898347 0.07411900963782186 1.0000000000067284e-14 13.999999999997078 -3.1781095533263084 TTTAAAVASTGPSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTTAAAVASTGPSSR 15 0 P27816-6;P27816;E7EVA0;P27816-2;P27816-5;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 10987100.0 2581400.0 4637900.0 3767800.0 False True 3384240.398313162 3945943.3983926037 3377944.199289685 1.0 1.1659760932939092 0.9981395532579143 21.690400622751238 -6.648724421829153 2.0130218465968905 1.1078101275453276 0.9988436918404208 0.1889254809947356 0.07086260751206722 0.5116591449820264 3.972700101355421 0.028563130243081554 0.07848813524092142 2.2453062133667534e-07 6.648724421829153 -0.10896643570490683 TTTAAAVASTGPSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTTAAAVASTGPSSR 15 0 P27816-6;P27816;E7EVA0;P27816-2;P27816-5;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 8412000.0 2323600.0 1478200.0 4610200.0 False True 2249838.589874334 2068452.9687111638 3402650.3169645853 1.0 0.9193783847519027 1.5123975258841311 21.101390071237205 -6.8725744809022 1.1203295145480627 0.9536056542647249 1.5488789924068302 0.96718857681102 0.04757076277191293 0.1344132613008085 0.3137391084805659 0.03289800974288366 0.0782583225027851 1.3409899377665818e-07 6.8725744809022 0.5952733381421054 TTTAAAVASTGPSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTTAAAVASTGPSSR 15 0 P27816-6;P27816;E7EVA0;P27816-2;P27816-5;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 20717700.0 3269400.0 15603000.0 1845300.0 False True 4959918.825156143 12818522.743204577 1480575.6461762767 1.0 2.5844218817030815 0.2985080398225402 22.241885078746204 -6.720265354393392 1.7582598745462759 1.9636727803282024 0.30199767252144044 0.5137848584088645 0.6667102186249758 0.35481776434410145 2.143847061227397 0.3010563267148611 0.7555569214108859 1.904296835027681e-07 6.720265354393392 -1.661675107806762 TTTAAAVASTGPSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTTAAAVASTGPSSR 15 0 P27816-6;P27816;E7EVA0;P27816-2;P27816-5;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 10659200.0 2581400.0 3881400.0 4196400.0 False True 3535813.339711981 3709906.913926619 3205296.7475708732 1.0 1.049237207252807 0.9065231785770596 21.75361068427413 -6.813555867101955 1.3996052077643466 1.026722910146079 0.9038197500302134 0.8688986931431806 0.021430922775680428 0.2019872547044332 0.7791416816229658 0.012037914913804765 0.027803108668186142 1.5361871674142652e-07 6.813555867101955 -0.12290316011586566 TTTAAAVASTGPSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTTAAAVASTGPSSR 15 0 P27816-6;P27816;E7EVA0;P27816-2;P27816-5;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 5606900.0 2323600.0 2275500.0 1007800.0 False True 1932176.3529335065 2263241.4298486155 1218526.320459283 1.0 1.1713430952679205 0.6306496395162212 20.88179534667148 -6.821507244759332 1.3655095454314248 1.0922146010433076 0.6184768704886109 0.8877695968047663 0.07558353752479349 0.19153822973892073 0.7013831430707671 0.04349389104592408 0.10019998860222717 1.5083174490693706e-07 6.821507244759332 -0.4737377305546967 TTTAAAVASTGPSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTTAAAVASTGPSSR 15 0 P27816-6;P27816;E7EVA0;P27816-2;P27816-5;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 8309500.0 3269400.0 2555800.0 2484300.0 False True 4232302.749508799 2413567.4832712365 2032182.8910706001 1.0 0.5702728812468236 0.4801600951884775 22.013011400838653 -13.999999999992339 0.2195589662718642 3.588155546730258 0.43175439898304335 0.999497453919311 0.0050847069533020185 12.987643594541066 0.14844371775061124 14.57068873259247 0.05001602824978604 1.0000000000176411e-14 13.999999999992339 -3.1564011477472147 TTTESEVMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTTESEVMK 9 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 1706890.0 893260.0 813630.0 0.0 False True 864903.9502458031 1138516.7020243977 0.0 1.0 1.3163504475853471 0.0 19.72218040117684 -6.878444159047121 1.343303667939459 1.1653095605829207 5.5631001889900395e-18 0.9288067521742287 0.1496960723040774 0.15006871298547728 0.5443768819318766 0.09036401905858049 0.1844746994109028 1.322987804922199e-07 6.878444159047121 -1.1653095605829207 down TTTESEVMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTTESEVMK 9 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 1783530.0 893260.0 713330.0 176940.0 False True 742785.2681276401 709487.1497050808 213937.33592187517 1.0 0.9551712724371946 0.28802043484404727 19.502585676611115 -6.920523136847642 0.8208520903523 1.0144449199342735 0.17913642627406715 0.9943246260792917 0.024527513278251083 0.09786516287161494 0.10403147876422274 0.021191605381433217 0.06379845887775905 1.2008170983074464e-07 6.920523136847642 -0.8353084936602064 down TTTGSYIANR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTTGSYIANR 10 0 P28072;I3L3X7;A0A087X2I4 P28072 PSMB6 Proteasome subunit beta type-6;Proteasome subunit beta type 0 13203100.0 2714100.0 5695300.0 4793700.0 False True 3558211.383381792 4845583.440105528 4297693.908417371 1.0 1.3618031415267389 1.2078242255334366 21.762720788950606 -10.31806505583096 5.565844208496069 0.999954394503203 1.2848136835300918 0.8202026624810776 0.06286162922175902 3.5580022729138634e-05 4.359225950563392e-06 0.06087523576322719 0.020288503590942728 4.8076732575114877e-11 10.31806505583096 0.28485928902688884 TTTGSYIANR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTTGSYIANR 10 0 P28072;I3L3X7;A0A087X2I4 P28072 PSMB6 Proteasome subunit beta type-6;Proteasome subunit beta type 0 15914500.0 5401900.0 3542500.0 6970100.0 False True 5230419.641350567 4957038.723893448 5144421.711482118 1.0 0.9477325078668968 0.9835581204252584 22.318495269182296 -10.042346887648739 4.375407113551312 1.0000020435378043 0.9656453141570687 0.5507824511678787 0.014625745098366026 20245336.467426106 3.4086976980573622 452.29178853396036 0.0050067815667225605 9.070957086348527e-11 10.042346887648739 -0.03435672938073564 TTTGSYIANR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTTGSYIANR 10 0 P28072;I3L3X7;A0A087X2I4 P28072 PSMB6 Proteasome subunit beta type-6;Proteasome subunit beta type 0 46035300.0 9300000.0 29794000.0 6941300.0 False True 14108779.921071803 24477027.9184155 5569349.012520129 1.0 1.734879135924324 0.3947434890668449 23.75008989821864 -6.7578060507753435 1.620606307829162 1.42801821474004 0.3903502184838789 0.6819988367687225 0.3090036460596421 0.28661689820436764 1.4830829425009215 0.15047469265504687 0.36241977479258786 1.7466019843143574e-07 6.7578060507753435 -1.037667996256161 TTTGSYIANR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTTGSYIANR 10 0 P28072;I3L3X7;A0A087X2I4 P28072 PSMB6 Proteasome subunit beta type-6;Proteasome subunit beta type 0 10565300.0 2714100.0 3785200.0 4066000.0 False True 3717576.1157946438 3617957.3480174807 3105694.5418985784 1.0 0.9732033011095809 0.8354084610947438 21.825930850473497 -6.939181470212074 0.6671350674855132 1.0015707107909262 0.7991275846687633 0.998054702328877 0.0031803488569387105 0.08814206749733958 0.05632513468215096 0.0030769569159512255 0.011903138832624461 1.1503196267558955e-07 6.939181470212074 -0.20244312612216286 TTTGSYIANR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTTGSYIANR 10 0 P28072;I3L3X7;A0A087X2I4 P28072 PSMB6 Proteasome subunit beta type-6;Proteasome subunit beta type 0 11282400.0 5401900.0 3930300.0 1950200.0 False True 4491919.194745877 3909126.6937965336 2357977.803294 1.0 0.8702575723911005 0.5249377161664189 22.098900544616573 -6.954106375610607 0.5117861373851793 1.006263134374177 0.37373637272583315 0.9994853554631381 0.004548248623884598 0.08187762361245317 0.029454169418643785 0.0052226843645287 0.02850358282547786 1.1114594542869903e-07 6.954106375610607 -0.6325267616483439 TTTGSYIANR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTTGSYIANR 10 0 P28072;I3L3X7;A0A087X2I4 P28072 PSMB6 Proteasome subunit beta type-6;Proteasome subunit beta type 0 23742400.0 9300000.0 6827400.0 7615000.0 False True 12039033.330406757 6447449.188233055 6229148.136498259 1.0 0.5355454222349277 0.5174126497985032 23.52121622031109 TTTHVPPELGQIMDSETFEK(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTTHVPPELGQIMDSETFEKSR 22 1 O75844 O75844 ZMPSTE24 CAAX prenyl protease 1 homolog 1 15462400.0 2047700.0 4507400.0 8907300.0 True False 2684554.529955007 3834913.4897075845 7985658.04085488 1.0 1.428510185550918 2.974667845912118 21.35625127923163 -6.947244893151675 0.5883133894688652 0.9820369819876511 3.4987165415407393 0.9989669617599464 0.02725886518537019 0.08461127273332791 0.040688903164139464 0.028309615595208556 0.12946459075931044 1.1291590166680792e-07 6.947244893151675 2.516679559553088 up TTTHVPPELGQIMDSETFEK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTTHVPPELGQIMDSETFEKSR 22 1 O75844 O75844 ZMPSTE24 CAAX prenyl protease 1 homolog 1 26382100.0 4080200.0 3910900.0 18391000.0 True False 3950676.284388566 5472542.765074077 13573845.38182634 1.0 1.3852166999101638 3.4358282999456438 21.913668207074707 -6.938417667138853 0.6741216735974417 0.9762311293128059 3.9639912844896266 0.9979492403362317 0.04841426071380084 0.08849594645445545 0.05795254646793703 0.046580785653996676 0.1777576430902201 1.1523444987674195e-07 6.938417667138853 2.9877601551768205 up TTTHVPPELGQIMDSETFEK(ub)SR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTTHVPPELGQIMDSETFEKSR 22 1 O75844 O75844 ZMPSTE24 CAAX prenyl protease 1 homolog 1 15589700.0 2047700.0 2632000.0 10910000.0 True False 2804790.027011783 2515709.537139917 8333282.69850307 1.0 0.8969332865961978 2.971089678103758 21.41946134075452 -6.895206611828362 0.9910382160140712 0.9020610826391673 3.16882669327275 0.9840280254614694 0.12061754094132497 0.11502150604422647 0.19796819557699857 0.09203885404868911 0.23420852591669297 1.272897367077937e-07 6.895206611828362 2.2667656106335827 up TTTHVPPELGQIMDSETFEK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTTHVPPELGQIMDSETFEKSR 22 1 O75844 O75844 ZMPSTE24 CAAX prenyl protease 1 homolog 1 24328600.0 4080200.0 5668400.0 14580000.0 True False 3392867.08350805 5637863.204110701 17628610.589696728 1.0 1.6616811284812962 5.195785792902223 21.694073482508983 -6.938344262673373 0.6747898516033138 0.9589654370653958 6.104130457077167 0.9979389121143443 0.08361939420678109 0.08853014872318694 0.05811044947995341 0.08041027620999584 0.30645857869744714 1.1525392845277204e-07 6.938344262673373 5.145165020011771 TTTLSGTAPAAGVVPSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTTLSGTAPAAGVVPSR 17 0 P27816-6;P27816;E7EVA0;P27816-2;P27816-5;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 15017400.0 2715600.0 4742000.0 7559800.0 False True 3560177.89790781 4034512.0841712235 6777584.414722163 1.0 1.1332332821183355 1.9037207153904048 21.763517902093646 -6.93661982396106 0.6902963371919055 0.9906411224217669 2.0923418480771008 0.9976867672007124 0.019158861655977626 0.08934308098740457 0.06188964727379139 0.018202698476306275 0.06736089406547463 1.15712473170135e-07 6.93661982396106 1.1017007256553337 TTTLSGTAPAAGVVPSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTTLSGTAPAAGVVPSR 17 0 P27816-6;P27816;E7EVA0;P27816-2;P27816-5;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 13612400.0 4306600.0 1894300.0 7411500.0 False True 4169889.3403136604 2650703.8686439996 5470205.80976597 1.0 0.6356772691825469 1.3118347666642156 21.991577667550697 -6.760348468906679 1.6110343634793085 0.7884726988539603 1.3143578741477013 0.6924271098601695 0.1532434789807322 0.282337444936924 1.4443121795809284 0.07504645467492486 0.18029537429751752 1.7364070125790826e-07 6.760348468906679 0.525885175293741 TTTLSGTAPAAGVVPSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTTLSGTAPAAGVVPSR 17 0 P27816-6;P27816;E7EVA0;P27816-2;P27816-5;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 31152300.0 4118500.0 23323000.0 3710800.0 False True 6248065.6026811 19160828.426569257 2977358.7534985784 1.0 3.0666816971875543 0.47652488671389226 22.57497817071793 -6.694161260549403 1.8513676169165805 2.2905821968973537 0.48493937629379136 0.39004979687890295 0.8733363701173172 0.4078068970283992 2.7131061047750573 0.37690445191666117 0.9764630547054691 2.022268138456785e-07 6.694161260549403 -1.8056428206035622 TTTLSGTAPAAGVVPSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTTLSGTAPAAGVVPSR 17 0 P27816-6;P27816;E7EVA0;P27816-2;P27816-5;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 18410400.0 2715600.0 7408300.0 8286500.0 False True 3719630.7063306165 7080976.81002797 6329399.365824526 1.0 1.9036773725887677 1.7016203665197784 21.826727963616538 -10.158161668188653 4.794104349190235 0.9999284384161349 1.8026488693742173 0.954627586968706 0.08248942732974857 10519814.85432809 22290300.86557098 5388.983389422754 0.028238325574306642 6.947656396274611e-11 10.158161668188653 0.8027204309580824 TTTLSGTAPAAGVVPSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTTLSGTAPAAGVVPSR 17 0 P27816-6;P27816;E7EVA0;P27816-2;P27816-5;P27816-4;H0Y2V1;H7C4C5;B5MEG9;F8W9U4 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 7506930.0 4306600.0 2226100.0 974230.0 False True 3581128.714728633 2214107.557453746 1177936.988669427 1.0 0.6182708676031279 0.32892897254006903 21.771982942984973 -7.848462214636063 0.22301095605262297 1.1977001826255362 4.259033845680711e-11 0.999809773353442 0.003790492251057007 0.1196547516482955 0.03413746877827527 0.057715314768235805 0.09104271638924306 1.4175480384495992e-08 7.848462214636063 -1.1977001825829459 down TTTPVYVALGIFVQHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTTPVYVALGIFVQHR 16 0 P54619;P54619-3;F8VYY9;P54619-2;F8VPF5 P54619 PRKAG1 5-AMP-activated protein kinase subunit gamma-1 0 12257100.0 2746800.0 4975900.0 4534400.0 False True 4167096.4179784935 4087911.768115855 3638173.8525018776 1.0 0.9809976439419532 0.8730716757129411 21.990611050725363 -6.937010420842454 0.686842743385377 1.0012967477959234 0.8463631251452383 0.9977450663866981 0.0026543092142313866 0.08915803303836947 0.06102824827718601 0.002528563730748402 0.009417869640566876 1.1560845017544529e-07 6.937010420842454 -0.1549336226506851 TTTVNIGSISTADGSALVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTTVNIGSISTADGSALVK 19 0 Q96B26 Q96B26 EXOSC8 Exosome complex component RRP43 0 9920400.0 1737900.0 3827400.0 4355100.0 False True 2278403.7298475388 3256366.839088346 3904476.0290690865 1.0 1.4292317013132032 1.713689271975673 21.11959198249856 -8.36123795885069 0.0920876880169984 1.4585507173291699e-09 2.750462018205987 0.9999870725206299 0.0010547322245359609 0.10222631522671696 0.020558825097297315 0.2993381008766202 0.2891332172970958 4.3527331316303025e-09 8.36123795885069 2.7504620167474365 TTTVNIGSISTADGSALVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTTVNIGSISTADGSALVK 19 0 Q96B26 Q96B26 EXOSC8 Exosome complex component RRP43 0 7521300.0 2410000.0 0.0 5111300.0 False True 2333495.8691673023 0.0 3772497.1942868163 1.0 0.0 1.6166718973593106 21.154061482721314 -6.739392187288299 1.6890549489952635 0.40458977962843223 1.6174759016857978 0.6021888538584612 0.4201617163077795 0.31889855881948415 1.7861654534171978 0.19681538925578446 0.4832650138262589 1.8222493866080867e-07 6.739392187288299 1.2128861220573657 TTTVNIGSISTADGSALVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTTVNIGSISTADGSALVK 19 0 Q96B26 Q96B26 EXOSC8 Exosome complex component RRP43 0 8242500.0 1737900.0 3042000.0 3462600.0 False True 2380448.5949815772 2907594.3814512207 2644805.194485489 1.0 1.2214480865417399 1.1110532695649147 21.18280204402145 -10.265880397599425 4.508944491926893 0.9999185952569155 1.1662506780544741 0.751485216397923 0.04506849531098257 3.689952698982361e-05 6.0077247715895505e-06 0.04365871935327313 0.014545794314259366 5.4215017513192527e-11 10.265880397599425 0.16633208279755862 TTTVNIGSISTADGSALVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTTVNIGSISTADGSALVK 19 0 Q96B26 Q96B26 EXOSC8 Exosome complex component RRP43 0 3985600.0 2410000.0 1575600.0 0.0 False True 2004021.7811024915 1567111.9300678866 0.0 1.0 0.7819834818390828 0.0 20.93446675815559 -7.279542591402145 0.8321828228948788 0.9890051366050256 1.1399383487637939e-17 0.9884998388181369 0.04604237763141778 0.10169037761588245 0.13761366039206752 0.039154892250464875 0.06914075803911338 5.253604903081648e-08 7.279542591402145 -0.9890051366050256 down TTVTELPQTSHVSFSEPDIPSSK(ub)STELPVDWSIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTVTELPQTSHVSFSEPDIPSSKSTELPVDWSIK 34 1 F8W8A5;Q9NYP3;H7C304;H7C006;F8WD19;C9J4K5;C9JSP0;Q9NYP3-2;Q9NYP3-3 F8W8A5 DONSON Protein downstream neighbor of Son 1 19107300.0 6472300.0 3975900.0 8659100.0 True False 8378519.938106621 3754637.6699030153 7083232.649868945 1.0 0.44812660202984356 0.8454038066620171 22.998263984306003 -10.570673619246488 5.8081299972381695 1.0011336527525594 0.6467652043459402 0.5131668198975033 0.1621877396313473 0.002387963161617324 0.00017651387159771086 0.15750527924120658 0.052345867879269356 2.6873632927664083e-11 10.570673619246488 -0.3543684484066192 TTVVAQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTVVAQLK 8 0 P60228;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 24434300.0 9984900.0 7522300.0 6927100.0 False True 13090300.59390915 6400002.161695744 6210350.141435204 1.0 0.48891177981609013 0.474423799276607 23.6419948906286 TTVVAQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTVVAQLK 8 0 P60228;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 12799500.0 3276500.0 2136300.0 7386700.0 False True 3172489.3009654256 2989335.7306573237 5451901.673750017 1.0 0.9422681834569573 1.7184933207153574 21.597183867994133 -6.888988795048183 1.0283720918455272 0.9572756550240294 1.7839416665422594 0.9802421813651567 0.04963205922035796 0.11996637642818013 0.22668377827660446 0.03682231938741243 0.0914685257014124 1.2912525879589627e-07 6.888988795048183 0.8266660115182299 TTVVAQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTVVAQLK 8 0 P60228;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 20137900.0 9984900.0 4742000.0 5411000.0 False True 13676587.361776615 4532482.760302988 4133033.243043084 1.0 0.33140451198888915 0.3021976998877734 23.70520495215149 -13.457591514095984 0.4519048642951451 9.999999999999998 0.30230582271212736 0.9998927123999991 0.0033382007355370375 21.539235431191127 0.22863528758861068 190.18248105801888 0.006567504672059518 3.486651060337628e-14 13.457591514095984 -9.697694177287872 TTVVAQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTVVAQLK 8 0 P60228;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 44185700.0 14192000.0 22454000.0 7539700.0 False True 18371823.76614332 21204415.161347654 6167551.963855013 1.0 1.1541812849535604 0.33570711554619537 24.1309915137294 -6.857978142478669 1.1959077387500405 1.083243494127485 0.2975755538715093 0.9511362998626486 0.07849854345834233 0.14889820578276983 0.4058077281599678 0.051235889979789916 0.11934087367347533 1.3868256243888604e-07 6.857978142478669 -0.7856679402559759 down TTVVAQLK(ub)QLQAETEPIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTVVAQLKQLQAETEPIVK 19 1 P60228;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 34056700.0 4282900.0 9250800.0 20523000.0 True False 4146941.6838409337 12944692.682284692 15147410.623197295 1.0 3.121503428110714 3.6526702755963596 21.98361632888417 -9.795704725324875 0.36223769300149544 2.7280804342910987e-23 3.7551877614124494 0.998665784203564 0.04185937150798794 1.137542315546646 0.15656430271114571 1.4445484356768832 0.15029564391767541 1.6006459300124454e-10 9.795704725324875 3.7551877614124494 TTVVAQLK(ub)QLQAETEPIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTVVAQLKQLQAETEPIVK 19 1 P60228;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 19781600.0 2664900.0 3722700.0 13394000.0 True False 3650185.546214628 3558218.804677341 10230613.058088914 1.0 0.9748049132371751 2.8027652097571925 21.799538370248353 -6.90377548245182 0.9370859328743024 0.9316707271867272 3.010061049624501 0.9883529800698585 0.09236255544590274 0.10867949270838363 0.1621590029176299 0.07336448679779385 0.19476532959667175 1.248028541761574e-07 6.90377548245182 2.0783903224377736 up TTVVAQLK(ub)QLQAETEPIVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTVVAQLKQLQAETEPIVK 19 1 P60228;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 39303900.0 4282900.0 16312000.0 18709000.0 True False 3561421.1146406103 16224124.018321503 22620965.399357747 1.0 4.555519691739321 6.351668244557053 21.764021604318447 -8.694942307549955 0.33037117996120974 2.2431361179003508e-22 7.053396654558256 0.998240637492152 0.09327742275666884 0.2736907966802529 0.10384877686343852 0.8788285468295499 0.5381023980727611 2.018634504862608e-09 8.694942307549955 7.053396654558256 TTVVAQLK(ub)QLQAETEPIVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTVVAQLKQLQAETEPIVK 19 1 P60228;H0YBR5;E5RIT4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 71582000.0 5483000.0 16223000.0 49876000.0 True False 7097851.5860881945 15320175.788836896 40799079.7709766 1.0 2.158424363065646 5.748088597814991 22.75895097772513 -6.950720312843913 0.5508785608535944 0.9506126152790605 7.124791969248842 0.9992566079425231 0.055112005952416124 0.0831977739129473 0.034775194503305296 0.05974996405745362 0.29784274499684493 1.1201590375435568e-07 6.950720312843913 6.174179353969782 TTVVYPATEK(ub)HLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTVVYPATEKHLQK 14 1 Q96C86;A0A3B3ITF0 Q96C86 DCPS m7GpppX diphosphatase 1 26190900.0 8785800.0 8794200.0 8610900.0 True False 8506899.588103777 12305769.92114716 6355446.968537242 1.0 1.446563438735753 0.7470932156557755 23.020201994552625 -6.734259560787301 1.7078662989785047 1.2674575242414732 0.7471872774958775 0.5788433281553949 0.1876696503877223 0.32830054427757355 1.8778813927087263 0.08701635965156299 0.21487799709211738 1.8439130552415076e-07 6.734259560787301 -0.5202702467455956 TTVVYPATEK(ub)HLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTVVYPATEKHLQK 14 1 Q96C86;A0A3B3ITF0 Q96C86 DCPS m7GpppX diphosphatase 1 26199200.0 8211900.0 6110300.0 11877000.0 True False 12458052.670306414 5019869.225008199 9529505.744125964 1.0 0.4029417243493426 0.7649273924519039 23.57057524120502 -10.339227333162723 6.413095123273398 1.0000240748548561 0.5839345584006674 0.6378761702322489 0.14778003017529012 5.087138293046034e-05 5.241679337581261e-06 0.14309566018182565 0.04769579964757732 4.57902133288939e-11 10.339227333162723 -0.4160895164541887 TTWVTK(ub)HAAENPGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTWVTKHAAENPGK 14 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 38486800.0 10640000.0 18998000.0 8848800.0 True False 13949143.037906557 16163572.45362399 7933211.059683244 1.0 1.1587502120882809 0.5687239021153399 23.73367315738151 -6.835084507877328 1.3050608858486967 1.0845742649873844 0.5511354014354255 0.9156608917184897 0.07239823559965258 0.17462020105167297 0.5798363535965889 0.04353206032903456 0.10019377971415613 1.4618926820831654e-07 6.835084507877328 -0.5334388635519589 TTWVTK(ub)HAAENPGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTWVTKHAAENPGK 14 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 33080000.0 10352000.0 11289000.0 11439000.0 True False 10023381.426398315 15796756.571357291 8442782.737355854 1.0 1.5759907659259371 0.8423088355313229 23.2568659535965 -6.697320740155409 1.840272987908586 1.358601204572378 0.8445884324665761 0.40491578271548034 0.24325418506327562 0.4011365033637666 2.639151541892035 0.10552561588019843 0.27230045704633055 2.007609582052708e-07 6.697320740155409 -0.514012772105802 TTWVTK(ub)HAAENPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTWVTKHAAENPGK 14 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 37002000.0 10640000.0 12270000.0 14092000.0 True False 14573895.535188435 11727870.828535995 10763759.833850168 1.0 0.8047176405388141 0.7385643603565871 23.7968832189044 -13.999999999992289 0.15114104618768665 1.9459692408191334 0.6667288426145157 0.9995624733293307 0.0023214920668783636 11.962187820896041 0.12249566220709279 3.322227719284092 0.06482099612571458 1.0000000000177557e-14 13.999999999992289 -1.2792403982046177 TTWVTK(ub)HAAENPGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTWVTKHAAENPGK 14 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 36591100.0 10352000.0 17961000.0 8278100.0 True False 8608146.671358097 17864240.52802065 10009012.436390163 1.0 2.07527139232657 1.162737209124604 23.037271229030775 -10.272174510172245 4.258561175461707 0.9995083786175236 1.6190043007296449 0.3802364875116163 0.37254052033553386 265825967.502864 145786373.3556281 1365692.4349540735 0.13633586702335865 5.3434960147960094e-11 10.272174510172245 0.6194959221121212 TTWVTK(ub)HAAENPGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTWVTKHAAENPGK 14 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 68945000.0 23260000.0 20824000.0 24861000.0 True False 30110528.52314634 19665126.09423283 20336553.095401578 1.0 0.6530980045440253 0.6753967496707544 24.843764695788913 -10.508157687386982 6.173479471337474 1.0003087741920518 0.66424737710739 0.9967027709099264 0.009103424577476565 3.87229466880808e-05 3.0850708324380105e-06 0.008822288436727006 0.0029381176485018257 3.103432562468731e-11 10.508157687386982 -0.33606139708466176 TTYDQMYNDLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTYDQMYNDLLR 12 0 Q9NP77;Q9NP77-2 Q9NP77 SSU72 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 0 1778240.0 0.0 961560.0 816680.0 False True 0.0 818098.9961315244 732177.7877477312 0.0 TTYDQMYNDLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTYDQMYNDLLR 12 0 Q9NP77;Q9NP77-2 Q9NP77 SSU72 RNA polymerase II subunit A C-terminal domain phosphatase SSU72 0 2334100.0 0.0 1321800.0 1012300.0 False True 0.0 1263398.5053919205 773215.5889729294 0.0 TTYDSSLSSYTVPLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTYDSSLSSYTVPLEK 16 0 Q8WWM7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7-3;H3BUF6;Q8WWM7-7;H3BSK9 Q8WWM7 ATXN2L Ataxin-2-like protein 0 9357100.0 1680500.0 3446500.0 4230100.0 False True 2203151.7739851475 2932295.6343517792 3792409.829984423 1.0 1.3309548933379782 1.7213565922989331 21.07113745430096 -6.968942454648383 0.2823073157694486 0.9163471793291785 2.1478982975166714 0.9999729168808582 0.0015343048756410974 0.07664739275715182 0.0102530139239298 0.007116676174742175 0.03573078974804786 1.0741317286627096e-07 6.968942454648383 1.2315511181874927 TTYDSSLSSYTVPLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTYDSSLSSYTVPLEK 16 0 Q8WWM7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7-3;H3BUF6;Q8WWM7-7;H3BSK9 Q8WWM7 ATXN2L Ataxin-2-like protein 0 10812500.0 3436500.0 2080700.0 5295300.0 False True 3327410.188545 2911534.360707161 3908302.074405143 1.0 0.8750151606587189 1.174577780599438 21.665968295629824 -6.793399928022419 1.4829143170972907 0.9304535348689112 1.1780602423073976 0.8120954079871265 0.05325439819660255 0.23032067765670858 1.000490766304969 0.028262837561651256 0.06600461362470333 1.609163125368875e-07 6.793399928022419 0.24760670743848634 TTYDSSLSSYTVPLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTYDSSLSSYTVPLEK 16 0 Q8WWM7;Q8WWM7-6;Q8WWM7-8;Q8WWM7-5;Q8WWM7-4;Q8WWM7-9;Q8WWM7-2;Q8WWM7-3;H3BUF6;Q8WWM7-7;H3BSK9 Q8WWM7 ATXN2L Ataxin-2-like protein 0 7798600.0 1680500.0 3239500.0 2878600.0 False True 2301826.2638049023 3096368.1784060574 2198733.966627948 1.0 1.3451789247064125 0.9552128243568898 21.13434751582385 -6.673122298465526 1.9264831030654859 1.2197369880335835 0.9567728748439963 0.2928433555978487 0.14652074314027724 0.45400646126478217 3.251428311913004 0.06116742743515784 0.1627509983678569 2.1226466349679213e-07 6.673122298465526 -0.26296411318958723 TTYGGAAAAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTYGGAAAAVR 11 0 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 4800700.0 1268800.0 1654400.0 1877500.0 False True 1663409.087076678 1407569.968800691 1683234.3102517084 1.0 0.8461959115988684 1.0119184290437369 20.665711587809575 -13.70687460461073 12.707958543172584 8.786224070966856 0.9361514532891726 0.0 0.07726420260567739 0.0 0.0 0.0 0.0224636937870633 1.9639272466743518e-14 13.70687460461073 -7.850072617677684 TTYGGAAAAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTYGGAAAAVR 11 0 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 2560200.0 1141800.0 1418400.0 0.0 False True 1105554.1839897216 1984774.516858284 0.0 1.0 1.795275659575213 0.0 20.076338303711807 -6.796222464601416 1.5369350270972981 1.4460604362603617 1.592642822805978e-19 0.7886709187151291 0.33765592598817806 0.23454534818719983 1.1045287329210172 0.17462754075072337 0.3958543947229975 1.5987388749528646e-07 6.796222464601416 -1.4460604362603617 TTYGGAAAAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTYGGAAAAVR 11 0 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 11075800.0 2100300.0 6386800.0 2588700.0 False True 3186308.65249754 5247025.6397038335 2077042.3103324845 1.0 1.6467411704107922 0.6518647553821962 21.60345459446095 -6.731275431991705 1.718837569558674 1.3886556813061701 0.6523446594900995 0.5650750409775038 0.27184750418767145 0.3338422609886941 1.9328861342703434 0.12531132734354963 0.3104729387942583 1.856626598646912e-07 6.731275431991705 -0.7363110218160707 TTYGGAAAAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTYGGAAAAVR 11 0 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 0 5042000.0 1268800.0 1859000.0 1914200.0 False True 1737909.6480307423 1776863.2331090784 1462105.384186487 1.0 1.0224140450123371 0.8413011492531995 20.728921649332467 -6.875911696549626 1.1023981654184247 1.0132638494404616 0.8294335883303141 0.9702329801647126 0.013908673005135028 0.1313106270952132 0.29472456356293064 0.0097523931251323 0.0233564986113176 1.3307249617338538e-07 6.875911696549626 -0.18383026111014744 TTYLVLDEADR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTYLVLDEADR 11 0 J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 31327600.0 7063600.0 10727000.0 13537000.0 False True 9260448.003999695 9126573.413518503 12136321.096073149 1.0 0.9855434002303809 1.3105544235906654 23.14265055951748 -6.896488357401288 0.9831760482746106 0.9851547278740664 1.3423407852192801 0.9847375331868768 0.01852137200202143 0.11403745211722549 0.19234422908474438 0.014216575014113894 0.036379562499028816 1.269146167353818e-07 6.896488357401288 0.3571860573452137 TTYLVLDEADR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTYLVLDEADR 11 0 J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 31043600.0 8208500.0 6030100.0 16805000.0 False True 7947925.660605724 8437950.376556067 12403266.360806465 1.0 1.0616544161175505 1.5605664786579285 22.92214694800423 -6.929882488619618 0.747749135591051 0.9923803397403438 1.662687189767363 0.9965152965649978 0.014816094252058789 0.09269845399110206 0.07797721731444873 0.01348886261956836 0.04517196021162118 1.175215501677469e-07 6.929882488619618 0.6703068500270192 TTYLVLDEADR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTYLVLDEADR 11 0 J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 55886000.0 10310000.0 34330000.0 11246000.0 False True 15641023.761962397 28203543.27848571 9023223.170703107 1.0 1.8031775737771247 0.5768946654660034 23.898831609591355 -6.729981335853206 1.723132883397978 1.4833525158440746 0.5776031427208553 0.5592603554999098 0.33763720397690317 0.33626859142983917 1.9560062690192366 0.15527290853943726 0.38533164627715766 1.862167163041089e-07 6.729981335853206 -0.9057493731232192 TTYLVLDEADR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTYLVLDEADR 11 0 J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 28582600.0 7063600.0 10205000.0 11314000.0 False True 9675203.806612503 9754109.356577825 8641866.219144246 1.0 1.0081554406028526 0.8931973312270668 23.205860621040372 -6.889867825724158 1.02318319037984 1.0061964379858073 0.8833361259322028 0.9808128690106641 0.007254920168141543 0.11924969555084393 0.22248396435013895 0.005403639313762905 0.013464727751014333 1.2886416804722207e-07 6.889867825724158 -0.12286031205360448 TTYLVLDEADR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTYLVLDEADR 11 0 J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 16541400.0 8208500.0 4409800.0 3923100.0 False True 6825731.448207385 4386043.532123229 4743402.071635065 1.0 0.6425748750011426 0.6949294896271968 22.702552223438506 -10.260981579323408 5.521950228782522 1.0000274998350365 0.6687521823142373 0.9816090679578684 0.021373681919025257 7.2366595543812175e-06 9.6853149856495e-07 0.020696694038119166 0.00689832617662019 5.483002206776417e-11 10.260981579323408 -0.3312753175207992 TTYLVLDEADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTYLVLDEADR 11 0 J3KTA4;P17844;P17844-2;J3KRZ1;J3QSF1 J3KTA4 DDX5 Probable ATP-dependent RNA helicase DDX5 0 31095400.0 10310000.0 11929000.0 8856400.0 False True 13346498.24048319 11265140.663566247 7244626.074337908 1.0 0.8440521596441172 0.5428110013428981 23.669957931683804 -6.960719095893558 0.42518060510326483 1.012595723620559 0.3628067835773983 0.9997959391449344 0.002710746563700774 0.07944527888252942 0.020189774703014314 0.003911418841132959 0.025041606507719315 1.0946641722665319e-07 6.960719095893558 -0.6497889400431607 TTYMDPTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTYMDPTGK 9 0 A6NFX8;Q9UKK9;A6NJU6;A6NCQ0;C9JYY9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 5785710.0 823110.0 2712400.0 2250200.0 False True 1079105.1810085773 2307720.4928523917 2017370.8894425526 1.0 2.1385501000889446 1.8694849445139652 20.04140406132706 -10.102357333642992 4.449702240046618 0.9999137121465654 2.0040175219956677 0.9488895988350177 0.10984539033022886 38239865.389014855 8.284790365307199 39861.59908571015 0.03760299874135514 7.900283322117529e-11 10.102357333642992 1.0041038098491022 TTYMDPTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTYMDPTGK 9 0 A6NFX8;Q9UKK9;A6NJU6;A6NCQ0;C9JYY9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 7588200.0 2226500.0 1447200.0 3914500.0 False True 2155820.976224481 2025074.5070483028 2889175.0175172216 1.0 0.939351889318214 1.3401739056167241 21.039805948046894 -6.868337980598105 1.1427734547830495 0.9660175210919427 1.3629260447521812 0.9630001989678475 0.033931254701295474 0.13846258922894075 0.338981753678003 0.023064781830012964 0.054457839962183854 1.3541351748044296e-07 6.868337980598105 0.39690852366023843 TTYMDPTGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TTYMDPTGK 9 0 A6NFX8;Q9UKK9;A6NJU6;A6NCQ0;C9JYY9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 17071400.0 3362100.0 12062000.0 1647300.0 False True 5100551.502433931 9909441.859163845 1321710.4329627608 1.0 1.9428177236197222 0.25913088659766575 22.28222181774354 -6.754738365148148 1.632211585200446 1.5512037449437963 0.25451455099094467 0.6691605879197347 0.39630829428702385 0.29184266320856117 1.5310568610569126 0.19169101783796005 0.4631005166829005 1.7589829703904305e-07 6.754738365148148 -1.2966891939528518 TTYMDPTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTYMDPTGK 9 0 A6NFX8;Q9UKK9;A6NJU6;A6NCQ0;C9JYY9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 5257010.0 823110.0 2149300.0 2284600.0 False True 1127436.0107113675 2054336.8192153536 1745024.5328139407 1.0 1.8221316329244694 1.5477814405740857 20.104614122849952 -10.12496968926897 4.424313041340665 0.9999283116128946 1.6849565364989658 0.8926003574154923 0.11200299774616763 39078255.62914756 6.798996885713002 36663.91209400226 0.038341605118134836 7.499465485535113e-11 10.12496968926897 0.6850282248860712 TTYMDPTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TTYMDPTGK 9 0 A6NFX8;Q9UKK9;A6NJU6;A6NCQ0;C9JYY9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 5393850.0 2226500.0 2429200.0 738150.0 False True 1851433.4006741485 2416113.4174415516 892493.7521800168 1.0 1.3049961270882282 0.4820555532027454 20.82021122348117 -6.806343062637339 1.429701452638289 1.1669532138774577 0.4688117226302313 0.8501040433969185 0.13151678807741876 0.21182788796903881 0.8540094839703762 0.0723434544224331 0.16765091638946966 1.5619133515603154e-07 6.806343062637339 -0.6981414912472264 down TTYMDPTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TTYMDPTGK 9 0 A6NFX8;Q9UKK9;A6NJU6;A6NCQ0;C9JYY9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 8361100.0 3362100.0 2636900.0 2362100.0 False True 4352304.72689899 2490154.1969786105 1932222.037192717 1.0 0.5721461049334294 0.44395375747723026 22.05334813983599 -13.999999999143009 0.16889662990821047 3.151517990276368 0.3295348891000795 0.9995158267892197 0.005231196624055492 12.080990122743023 0.13011887821931803 8.515050330003504 0.10557306463941693 1.0000000019732945e-14 13.999999999143009 -2.8219831011762886 TTYPIDETMIHNGPPHNSNFGYSYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TTYPIDETMIHNGPPHNSNFGYSYAK 26 0 Q13630;E9PKL9;E9PP14;A0A0J9YX13 Q13630 TSTA3 GDP-L-fucose synthase 0 10155000.0 3000800.0 1706100.0 5448100.0 False True 2905541.246554871 2387354.627193966 4021079.170503401 1.0 0.821655734546765 1.3839346370564294 21.470375504378097 -6.821401901945259 1.3656791876798506 0.9040022513474365 1.3965931498881918 0.8875819641049955 0.07866138925208256 0.191681196832686 0.7020657282762232 0.04525623282485396 0.10427747045994845 1.5086833521214985e-07 6.821401901945259 0.49259089854075533 TTYQALPCLPSMYGYPNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TTYQALPCLPSMYGYPNR 18 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 7632000.0 1577800.0 2685800.0 3368400.0 False True 2068511.079436933 2285089.109166402 3019870.2799743526 1.0 1.1047023783834038 1.4599246337111176 20.98016125433542 -6.948658499501119 0.5733914601322765 0.9956402175602482 1.5863580445180185 0.9990916889775393 0.005932079005101729 0.08402911927770895 0.03822795682895121 0.006260637226418263 0.029622029040181356 1.1254896368219015e-07 6.948658499501119 0.5907178269577703 TTYQALPCLPSMYGYPNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TTYQALPCLPSMYGYPNR 18 0 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3ITI7 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 0 7350700.0 1577800.0 2913000.0 2859900.0 False True 2161155.2984417584 2784294.0279971785 2184450.5214893594 1.0 1.2883359331024091 1.0107790601926652 21.043371315858312 -10.63679072699083 3.511480520494088 0.9920678644610033 1.1495574966579247 0.2790843995684327 0.11331211890741964 0.0073803540026494375 0.0007633850107542921 0.1150710004866537 0.0365713291163051 2.3078590063301566e-11 10.63679072699083 0.15748963219692147 TVAGGAWTYNTTSAVTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVAGGAWTYNTTSAVTVK 18 0 C9J4Z3;P61513 C9J4Z3 RPL37A 60S ribosomal protein L37a 0 54049000.0 14279000.0 21094000.0 18676000.0 False True 18719907.278032705 17946857.423768003 16743586.672842005 1.0 0.958704397260992 0.8944267951845115 24.158069953307336 -6.964635689711912 0.36425931632532044 1.0052761593921826 0.8456376852171801 0.99990540894723 0.00042244074979471514 0.07808488378723276 0.015297777859757623 0.0008553610443882906 0.005476448727675688 1.0848365534827127e-07 6.964635689711912 -0.15963847417500254 TVAGGAWTYNTTSAVTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVAGGAWTYNTTSAVTVK 18 0 C9J4Z3;P61513 C9J4Z3 RPL37A 60S ribosomal protein L37a 0 52116000.0 13842000.0 10038000.0 28236000.0 False True 13402593.286727728 14046225.747478474 20840144.538157165 1.0 1.048022979357892 1.5549337424716654 23.67600884100813 -6.925326584021265 0.7841860573785309 0.9908131419842633 1.6476158924939572 0.995537824606496 0.016769740649475336 0.09513723739781761 0.09010166131187872 0.014872973692779746 0.04709974473806876 1.1876088245754737e-07 6.925326584021265 0.6568027505096939 TVAGGAWTYNTTSAVTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVAGGAWTYNTTSAVTVK 18 0 C9J4Z3;P61513 C9J4Z3 RPL37A 60S ribosomal protein L37a 0 80296000.0 14094000.0 48910000.0 17292000.0 False True 21381628.40941785 40181628.36442583 13874228.62064715 1.0 1.8792595023645275 0.6488854990359876 24.349868396069237 -6.714804806958123 1.7776823641969206 1.5378526028661637 0.6512918533846502 0.4881125843442009 0.37024773419857465 0.36547502426348444 2.254133110008055 0.1655498016772494 0.41820425505190995 1.9283914312555057e-07 6.714804806958123 -0.8865607494815134 TVAGGAWTYNTTSAVTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVAGGAWTYNTTSAVTVK 18 0 C9J4Z3;P61513 C9J4Z3 RPL37A 60S ribosomal protein L37a 0 46620000.0 14279000.0 14488000.0 17853000.0 False True 19558332.175465778 13847872.254590834 13636489.09407657 1.0 0.7080293007786105 0.697221469179379 24.221280014830228 TVAGGAWTYNTTSAVTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVAGGAWTYNTTSAVTVK 18 0 C9J4Z3;P61513 C9J4Z3 RPL37A 60S ribosomal protein L37a 0 35245700.0 13842000.0 11842000.0 9561700.0 False True 11510236.30457291 11778204.795547042 11561007.261694321 1.0 1.0232808852818835 1.0044109396000185 23.456414116442406 -6.593925990882423 2.2128963345559765 1.0157171513129402 1.0044670458322413 0.0037299377629889108 0.010078075894324866 0.6581245866227566 6.080977647864335 0.0037924423991892594 0.011229336301963513 2.547264300745384e-07 6.593925990882423 -0.011250105480698824 TVAGGAWTYNTTSAVTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVAGGAWTYNTTSAVTVK 18 0 C9J4Z3;P61513 C9J4Z3 RPL37A 60S ribosomal protein L37a 0 58853400.0 14094000.0 28602400.0 16157000.0 False True 18244960.834274497 27010651.29646973 13216591.784819728 1.0 1.4804444658345466 0.7243968296161749 24.120994718161686 -6.735019506295795 1.70496588676306 1.287504388146949 0.7244222460668329 0.5823332890715116 0.2019007198096037 0.3269195703699995 1.863933022030325 0.09375896417397607 0.2313428180085115 1.840689325224407e-07 6.735019506295795 -0.5630821420801161 TVAGQDAVIVLLGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVAGQDAVIVLLGTR 15 0 P30043;M0R192;A0A2R8YEP4;A0A2R8Y7Y9;M0QZL1 P30043 BLVRB Flavin reductase (NADPH) 0 19635300.0 5531400.0 6822000.0 7281900.0 False True 7251718.966153797 5804184.191947718 6528438.840917128 1.0 0.8003873590575961 0.9002608721308066 22.78989158514087 -10.147852703496307 4.654085010127074 1.00001571941271 0.8503241155938615 0.749663305697222 0.04077319098181836 6.84923464922071e-06 1.2540300910777722e-06 0.03948274100675064 0.013159490802686935 7.114547716833852e-11 10.147852703496307 -0.1496916038188485 TVAGQDAVIVLLGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVAGQDAVIVLLGTR 15 0 P30043;M0R192;A0A2R8YEP4;A0A2R8Y7Y9;M0QZL1 P30043 BLVRB Flavin reductase (NADPH) 0 34217000.0 15572000.0 7108000.0 11537000.0 False True 15077675.383681845 9946261.46773032 8515113.597418876 1.0 0.6596680996657406 0.5647497628602981 23.845910680951274 -13.999999999999996 0.17913985237944172 2.761208833278993 0.4886778525032522 0.9994991998913229 0.004181841536708364 12.19369375189505 0.13416448745364967 7.473542591491241 0.07139070483784866 1.0000000000000082e-14 13.999999999999996 -2.272530980775741 TVAGQDAVIVLLGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVAGQDAVIVLLGTR 15 0 P30043;M0R192;A0A2R8YEP4;A0A2R8Y7Y9;M0QZL1 P30043 BLVRB Flavin reductase (NADPH) 0 36993400.0 7695200.0 22134000.0 7164200.0 False True 11674180.99447653 18184014.766268656 5748192.729819588 1.0 1.5576265928095647 0.4923850960113829 23.476818005011307 -6.764449357521041 1.5955678699694065 1.3221030996625132 0.48759329510423294 0.7089160182421401 0.23471513216937692 0.2755089967104947 1.3832789202818487 0.11601046859794667 0.27759783799476784 1.7200879066163085e-07 6.764449357521041 -0.8345098045582802 down TVAGQDAVIVLLGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVAGQDAVIVLLGTR 15 0 P30043;M0R192;A0A2R8YEP4;A0A2R8Y7Y9;M0QZL1 P30043 BLVRB Flavin reductase (NADPH) 0 24589400.0 5531400.0 7642000.0 11416000.0 False True 7576508.060464415 7304351.171285424 8719775.91990019 1.0 0.9640788491205924 1.150896409046478 22.853101646663763 -6.856870702305468 1.2013190116009105 0.9806483840428732 1.1594223205341283 0.9497316799943427 0.018147123721653623 0.15006612448130593 0.41329958955674667 0.011795306205822947 0.027446166559309024 1.3903665080493422e-07 6.856870702305468 0.17877393649125506 TVAGQDAVIVLLGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVAGQDAVIVLLGTR 15 0 P30043;M0R192;A0A2R8YEP4;A0A2R8Y7Y9;M0QZL1 P30043 BLVRB Flavin reductase (NADPH) 0 27966400.0 15572000.0 5457800.0 6936600.0 False True 12948807.95656764 5428397.748111516 8387010.988785335 1.0 0.4192198823489564 0.6477052572651245 23.62631595638555 -10.238717786668428 5.539095343208945 1.0000283185968026 0.5334625698070251 0.8475372087691078 0.09327876370559617 3.2622868760394855e-05 4.48355250445623e-06 0.0903222443316862 0.030105591532204896 5.771413796977028e-11 10.238717786668428 -0.4665657487897775 TVAGQDAVIVLLGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVAGQDAVIVLLGTR 15 0 P30043;M0R192;A0A2R8YEP4;A0A2R8Y7Y9;M0QZL1 P30043 BLVRB Flavin reductase (NADPH) 0 23614600.0 7695200.0 10149000.0 5770400.0 False True 9961588.09506947 9584199.228311997 4720246.409303944 1.0 0.9621155920967799 0.473844768952076 23.247944327103756 -6.92238936842576 0.8068080427230063 1.0098740204450012 0.3906105234873113 0.994819281656135 0.017245896614259473 0.09678629658278938 0.09847845931934555 0.01505027927817431 0.046166074768530414 1.1956680697089835e-07 6.92238936842576 -0.6192634969576899 down TVAK(ub)CQVTPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVAKCQVTPR 10 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88;H3BR65 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 4034600.0 1085900.0 1681200.0 1267500.0 True False 1423625.4158705575 1430371.5132662742 1136351.2587185293 1.0 1.0047386744578393 0.7982094489537067 20.44113816383347 -6.901648721638894 0.9507751544919506 1.0082026093839782 0.7757891345411159 0.9873691670097218 0.01081851915196853 0.11020219255685686 0.17064974623784834 0.008506752521921578 0.022322208418802152 1.25415518610803e-07 6.901648721638894 -0.23241347484286234 TVAK(ub)CQVTPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVAKCQVTPR 10 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88;H3BR65 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 9062500.0 1616700.0 1698500.0 5747300.0 True False 1565378.743436839 2376719.9075604896 4241909.714695802 1.0 1.5183034249860359 2.7098296386614744 20.578080328827532 -6.957233127639268 0.4728241736956147 0.969376895852396 3.3078353278346473 0.9996533924527458 0.013327147616613157 0.08070481731512376 0.024899332798043437 0.01656348216239705 0.09832466810869617 1.1034861137064346e-07 6.957233127639268 2.3384584319822515 TVAK(ub)CQVTPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVAKCQVTPR 10 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88;H3BR65 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 34873590.0 845010.0 597580.0 33431000.0 True False 1281941.9485059006 490937.18008614966 26823348.19667215 1.0 0.38296365967143475 20.92399599524353 20.289899501718498 -6.899972714199959 0.9614196146742178 0.14534222092835852 23.07908694034043 0.9865533618351645 1.1063737841257766 0.11142599428883647 0.1775240668111439 0.8631131944797141 2.2454169980310703 1.259004509889125e-07 6.899972714199959 22.933744719412072 up TVAK(ub)CQVTPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVAKCQVTPR 10 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88;H3BR65 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 3219510.0 1085900.0 1232000.0 901610.0 True False 1487386.5753440903 1177566.1663208099 688668.2872408199 1.0 0.7917014889343028 0.4630055821779245 20.504348225356363 -6.964400999115729 0.3681877243784012 1.025802025586237 0.2174961302651218 0.9999002599556538 0.0022076785419721345 0.07816481270966977 0.0155802336120406 0.004344766680446662 0.027943390679856527 1.0854229522352837e-07 6.964400999115729 -0.8083058953211152 down TVAK(ub)CQVTPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVAKCQVTPR 10 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88;H3BR65 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 9966400.0 1616700.0 1798400.0 6551300.0 True False 1344357.6819536937 1788711.6622455504 7921146.540211259 1.0 1.330532555626191 5.892142133408885 20.35848560426181 -6.9214752954995555 0.8137057913943827 0.9046036358590077 6.6533086507757755 0.994581110507219 0.16433041976184265 0.09731147446710077 0.1011716806181087 0.1427050079651387 0.4336916407341996 1.1981872791936603e-07 6.9214752954995555 5.7487050149167676 up TVAK(ub)CQVTPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVAKCQVTPR 10 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88;H3BR65 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 67324030.0 845010.0 976020.0 65503000.0 True False 1093882.1026373124 921703.6290094664 53582126.11753718 1.0 0.8425986921143243 48.98345625031482 20.061025823810947 -6.902025532583557 0.9495072344109279 3.0419493836986136e-15 54.22765369360352 0.9893978207895909 2.332901042541732 0.10453814851443541 0.1613436157840562 1.879478256579811 4.935357984503996 1.2530675037515348e-07 6.902025532583557 54.22765369360352 up TVALIK(ub)SAAVAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVALIKSAAVAER 13 1 Q96LD4;Q96LD4-2;K7EJ63 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 67845400.0 15433700.0 24140600.0 28271100.0 True False 20233730.160163388 20538916.579321776 25345877.767540388 1.0 1.0150830527412709 1.2526547288567635 24.270258974591723 -6.919840624012353 0.8259145234399882 0.9947279577636685 1.290824385510484 0.9941363939165664 0.00886050665628541 0.09826561702343652 0.10610304145989674 0.007627791907772935 0.022813942467339213 1.202705718705881e-07 6.919840624012353 0.29609642774681544 TVALIK(ub)SAAVAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVALIKSAAVAER 13 1 Q96LD4;Q96LD4-2;K7EJ63 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 139126500.0 25311500.0 43652000.0 70163000.0 True False 24508000.287314583 61082471.24217268 51785205.45511835 1.0 2.4923482342942993 2.1129918740013456 24.54674943755256 -10.211126622987466 5.232710727685729 0.999911519207396 2.302670054135161 0.9401991963454968 0.15487158564619308 0.0001753142659431439 2.643018860600585e-05 0.14996472942925926 0.04998458932199672 6.149975377604899e-11 10.211126622987466 1.3027585349277648 TVALIK(ub)SAAVAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVALIKSAAVAER 13 1 Q96LD4;Q96LD4-2;K7EJ63 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 122853400.0 23769000.0 24052400.0 75032000.0 True False 36059310.74666187 19760061.29774105 60201892.312306166 1.0 0.5479877703866068 1.6695242106888926 25.103868484945288 -6.79730379093618 1.466843510646054 0.7497460612119559 1.6840042858525246 0.8241789948960454 0.19318737743840741 0.22462795175242128 0.954432852785064 0.10362306375884474 0.24140121873728526 1.5947632129680642e-07 6.79730379093618 0.9342582246405687 TVALIK(ub)SAAVAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVALIKSAAVAER 13 1 Q96LD4;Q96LD4-2;K7EJ63 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 57069200.0 15433700.0 21314400.0 20321100.0 True False 21139955.97005994 20372659.330704764 15521674.70619161 1.0 0.963703962276843 0.7342340129835001 24.333469036114614 -6.934737946777928 0.7068168981851078 1.0029526257210708 0.6808867035189053 0.9973902802289444 0.006010961547361057 0.0902512035001875 0.06616734071692999 0.005639786946166067 0.02024953361105463 1.1621496432304959e-07 6.934737946777928 -0.32206592220216546 TVALIK(ub)SAAVAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVALIKSAAVAER 13 1 Q96LD4;Q96LD4-2;K7EJ63 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 107993500.0 25311500.0 53233000.0 29449000.0 True False 21047633.739574976 52946223.263076834 35606649.743208416 1.0 2.5155427882386743 1.6917174720813741 24.327154712986836 -10.01597601603588 5.236541546170083 0.9999922385820105 2.1036301301636025 0.7052625811096576 0.33632527697457215 3.0475402121719666e-05 5.727769766920339e-06 0.325647836595124 0.10854851638412491 9.638822526655521e-11 10.01597601603588 1.103637891581592 TVALIK(ub)SAAVAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVALIKSAAVAER 13 1 Q96LD4;Q96LD4-2;K7EJ63 Q96LD4 TRIM47 Tripartite motif-containing protein 47 1 72115800.0 23769000.0 30063400.0 18283400.0 True False 30769439.057036337 28390345.362147484 14956008.803526226 1.0 0.9226799783226857 0.48606699575519546 24.874994807037737 -6.9371319938717955 0.6857237142162845 1.0052282035408877 0.3776373041904304 0.9977636341738589 0.010699817622395887 0.08909969389242169 0.06075216431880513 0.010201687335338657 0.03807745834289245 1.1557609217167406e-07 6.9371319938717955 -0.6275908993504573 down TVANMIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVANMIK 7 0 E5RJR5;P63208;E7ERH2;F8W8N3;P63208-2 E5RJR5 SKP1 S-phase kinase-associated protein 1 0 3635500.0 1006600.0 1170400.0 1458500.0 False True 1319662.3479282674 995780.8821834669 1307588.4109199005 1.0 0.7545724735927636 0.9908507376698883 20.3317374146025 -10.664514820817631 8.691751939936658 1.0001544666938607 0.8727116056580642 0.27899993984667804 0.09646019738325533 0.000289077871832838 1.1157852784707271e-05 0.09350963537474939 0.031132394836435665 2.1651359901968752e-11 10.664514820817631 -0.1274428610357965 TVANMIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVANMIK 7 0 E5RJR5;P63208;E7ERH2;F8W8N3;P63208-2 E5RJR5 SKP1 S-phase kinase-associated protein 1 0 3763730.0 1045300.0 574230.0 2144200.0 False True 1012117.5236682913 803523.03356989 1582569.695378827 1.0 0.7939028964320496 1.5636224631730555 19.94894538995839 -6.835438430275656 1.3032789519289236 0.8902135605353073 1.586756637864733 0.9163430476177801 0.0940997262380354 0.17419641057430654 0.5766845109065725 0.056652809214043136 0.13040984864291974 1.4607018177726745e-07 6.835438430275656 0.6965430773294258 TVANMIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVANMIK 7 0 E5RJR5;P63208;E7ERH2;F8W8N3;P63208-2 E5RJR5 SKP1 S-phase kinase-associated protein 1 0 3745800.0 1006600.0 1113900.0 1625300.0 False True 1378767.2223421715 1064684.2148252851 1241437.6141042202 1.0 0.7722001202035105 0.900396813898242 20.39494747612539 -10.133045920491623 4.836317053710238 1.0000104999603758 0.8362984671069572 0.6849555594911857 0.05233608104722152 5.925615629482847e-06 1.0622248178552336e-06 0.05067744239133749 0.016891397524678223 7.361292581345325e-11 10.133045920491623 -0.16371203285341862 TVANMIK(ub)GK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVANMIKGK 9 1 E5RJR5;P63208;E7ERH2;F8W8N3;P63208-2 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 2545900.0 857220.0 1389900.0 298780.0 True False 1174157.3994994576 1328489.6222153357 228214.31756725433 1.0 1.131440829638062 0.1943643311063252 20.163194388552604 -6.87138851379009 1.1266625924045577 1.0750081644899137 0.13800181296686725 0.9660525356018445 0.07632514503910023 0.13553366037879974 0.3206891170301146 0.05252749478079245 0.12467551048772493 1.3446569045173558e-07 6.87138851379009 -0.9370063515230465 down TVANMIK(ub)GK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVANMIKGK 9 1 E5RJR5;P63208;E7ERH2;F8W8N3;P63208-2 E5RJR5 SKP1 S-phase kinase-associated protein 1 1 3942330.0 0.0 3212900.0 729430.0 True False 0.0 3034099.290633917 596681.224583838 0.0 TVAPMPPAQDHK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVAPMPPAQDHKR 13 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;H7C366 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 6122910.0 770290.0 655920.0 4696700.0 True False 997155.589685917 619417.4753999804 3841948.7922115983 1.0 0.6211843786535699 3.852908043589999 19.92745910539436 -6.877675613923632 1.0926281498059778 0.7716864893741071 4.072016182768475 0.9717640258495149 0.24238730593588392 0.1297114529524026 0.28486803823902407 0.17122340605932818 0.41174226833666744 1.325331090556962e-07 6.877675613923632 3.3003296933943673 up TVAPMPPAQDHKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVAPMPPAQDHKR 13 1 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;H7C366 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 1748610.0 558170.0 652620.0 537820.0 False True 846784.6976929726 536154.8620566666 431519.64126512024 1.0 0.6331655065536692 0.5095978262724591 19.691635672972282 -13.999999999999998 0.1519657378514057 2.7793824902382047 0.37667406048003127 0.9995598109013552 0.004369325745113265 11.965636484470128 0.12286934171552018 6.2837430779605326 0.12004412747474953 1.0000000000000041e-14 13.999999999999998 -2.4027084297581736 TVATLSILGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVATLSILGTR 11 0 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 0 13535500.0 3646300.0 5171500.0 4717700.0 False True 4780334.610819424 4399932.358349117 4229557.659373894 1.0 0.9204235093482087 0.884782761817772 22.188680175913902 -13.999999946503408 0.10859889507812734 1.3849472465783335 0.8180623361685713 0.9997501692549732 0.000761255512839677 12.021118712738001 0.09976850806995587 1.0173476925504186 0.05928446169028744 1.000000123180463e-14 13.999999946503408 -0.5668849104097622 TVATLSILGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVATLSILGTR 11 0 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 0 9385400.0 3370400.0 2008300.0 4006700.0 False True 3263408.496863689 2810224.663146148 2957225.071576511 1.0 0.8611317479398993 0.9061768008567004 21.637948157278885 -9.962527430812926 5.997558916334362 1.0000000697343652 0.883654275556066 0.898938733216722 0.01838956584721889 1.7137866977246778e-08 2.9861182158648376e-09 0.01780563118049629 0.005935206855843499 1.0901156365655941e-10 9.962527430812926 -0.11634579417829916 TVATLSILGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVATLSILGTR 11 0 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 0 15049900.0 3951000.0 6108900.0 4990000.0 False True 5993955.856790833 5018719.06594645 4003724.3128053066 1.0 0.8372966344522722 0.6679602600458426 22.515077028313556 -6.9706225897249 0.2428560693496583 1.058690475634029 0.4416512134518664 0.99998683776109 0.0004917884019117224 0.07610118836924869 0.008304014647336405 0.003967249100983635 0.01642583258819708 1.0699843123061523e-07 6.9706225897249 -0.6170392621821625 TVATLSILGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVATLSILGTR 11 0 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 0 13211400.0 3646300.0 4091500.0 5473600.0 False True 4994435.647552404 3910724.001218826 4180848.412330559 1.0 0.7830161958609545 0.8371012677637453 22.251890237436793 -9.913205231002218 5.124517733792075 1.00000051205931 0.8100587318088548 0.9426755753638705 0.022080138156099435 1.2915575850815e-07 2.741545485230522e-08 0.021379059177159005 0.0071263339449631905 1.221222420663047e-10 9.913205231002218 -0.18994178025045527 TVATLSILGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVATLSILGTR 11 0 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 0 7617700.0 3370400.0 2130800.0 2116500.0 False True 2802636.9340364523 2119320.957469313 2559050.364409676 1.0 0.7561881925308803 0.9130866482673676 21.41835343271316 -10.678315370941329 5.6686220134667265 1.0024827252939108 0.834637420399124 0.5969482498427992 0.06405352633084106 0.0020378439016938516 0.0001156440437761562 0.06288522548444196 0.020673186728767147 2.0974162530203797e-11 10.678315370941329 -0.16784530489478677 TVATLSILGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVATLSILGTR 11 0 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 0 14467700.0 3951000.0 6460000.0 4056700.0 False True 5114647.385853455 6100495.321203616 3318422.2252570516 1.0 1.1927499319067247 0.6488076254162579 22.286203350406005 -6.810930718098957 1.4107695551888066 1.1049297704820646 0.6391005078385276 0.8622141377010142 0.08358642312542829 0.20552960976495938 0.8060678299729622 0.04658710244441518 0.10771313420130442 1.5455009697372557e-07 6.810930718098957 -0.4658292626435371 TVATPLNQVANPNSAIFGGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVATPLNQVANPNSAIFGGAR 21 0 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 52142800.0 9060800.0 26655000.0 16427000.0 False True 11878796.54491203 22678177.900376234 14727291.618910672 1.0 1.909130930446808 1.2397966042459678 23.50188534659318 -10.181038687212393 4.625715999731398 0.9999154446634365 1.5744637673478055 0.4954973152912657 0.27325459448856987 0.00026362810877567723 4.667450179226782e-05 0.264620431895905 0.08819254113396836 6.591151782544988e-11 10.181038687212393 0.574548322684369 TVATPLNQVANPNSAIFGGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVATPLNQVANPNSAIFGGAR 21 0 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 58077900.0 20026000.0 8842900.0 29209000.0 False True 19390285.591678176 12373916.085114298 21558286.648782846 1.0 0.6381502751266785 1.1118086191590246 24.20883071668479 -6.702528885852042 1.821685143464688 0.7758642036698029 1.1104753690031788 0.42962125209916524 0.15267205633096248 0.39030733310814913 2.5198280766258208 0.06681375427873334 0.1713035825474999 1.9836777138140844e-07 6.702528885852042 0.33461116533337587 TVATPLNQVANPNSAIFGGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVATPLNQVANPNSAIFGGAR 21 0 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 58756700.0 9947000.0 43154000.0 5655700.0 False True 15090326.223107653 35452831.536259025 4537848.416018627 1.0 2.3493747591732306 0.3007124132989165 23.847120658636268 -6.729021058753126 1.7265265843825126 1.8129059734422686 0.30208094112741224 0.5548756302521953 0.5672888582993327 0.3380594327015987 1.9737121034898195 0.2604143963511126 0.6469854165202088 1.866289193078207e-07 6.729021058753126 -1.5108250323148562 TVATPLNQVANPNSAIFGGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVATPLNQVANPNSAIFGGAR 21 0 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 39286800.0 9060800.0 14575000.0 15651000.0 False True 12410822.618913123 13931028.306920316 11954556.14246301 1.0 1.1224903243472772 0.963236403382738 23.565095408116072 -6.701218754433615 1.826262974436055 1.075968380164648 0.9636947083925248 0.42351312549819575 0.05169294883325409 0.3929767157477033 2.548909804543533 0.022572916238193255 0.05797002302659893 1.9896708879259553e-07 6.701218754433615 -0.11227367177212322 TVATPLNQVANPNSAIFGGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVATPLNQVANPNSAIFGGAR 21 0 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 36363200.0 20026000.0 9130400.0 7206800.0 False True 16652506.302223446 9081212.722957496 8713708.55952169 1.0 0.5453360928465747 0.523267092735358 23.989235992119067 TVATPLNQVANPNSAIFGGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVATPLNQVANPNSAIFGGAR 21 0 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 23448700.0 9947000.0 8224700.0 5277000.0 False True 12876587.584683435 7766988.214907639 4316640.14659242 1.0 0.6031868430846065 0.33523168449745316 23.618246980728717 -8.228393845917772 0.19816225593041592 1.2818121978729067 2.1024080564076244e-07 0.9997895354144068 0.003961744950412625 0.0872088479176943 0.04181684007610583 0.10836166309047865 0.11573531003865936 5.91025411557113e-09 8.228393845917772 -1.281811987632101 down TVATPLNQVANPNSAIFGGARPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVATPLNQVANPNSAIFGGARPR 23 1 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 36925700.0 8832700.0 16554000.0 11539000.0 False True 11579755.235988468 14084207.726986608 10345054.969903829 1.0 1.2162785343868587 0.893374234522044 23.465101423276373 -6.726183808428082 1.7368542999741934 1.1307022398819724 0.8936856570075838 0.5416299165178442 0.09094876308689002 0.34343217684756694 2.0277741533768663 0.041524633751981066 0.10350017150644401 1.8785215932975406e-07 6.726183808428082 -0.23701658287438854 TVATPLNQVANPNSAIFGGARPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVATPLNQVANPNSAIFGGARPR 23 1 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 38202900.0 13813000.0 6669900.0 17720000.0 False True 13374513.875853926 9333225.853068998 13078600.41139485 1.0 0.6978366421166913 0.9778748246698288 23.67298311896717 -10.46074250950826 8.287705820895274 1.0000055041993265 0.8378557336161878 0.3089149498135694 0.11432510929192558 1.1627545196188995e-05 7.566543484598469e-07 0.11069856831573029 0.03689827036174754 3.461445439421415e-11 10.46074250950826 -0.16214977058313873 TVATPLNQVANPNSAIFGGARPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVATPLNQVANPNSAIFGGARPR 23 1 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 172776000.0 37495000.0 108260000.0 27021000.0 False True 56882656.25167609 88940157.16075923 21680287.506274994 1.0 1.5635725020864957 0.38114056084777453 25.76148550032997 -6.7770865873805475 1.5470902599205607 1.3203162210643489 0.3725944340395135 0.756986397953938 0.23805318959852 0.25512980790885326 1.2059137259357569 0.12121496834545645 0.28673650713073356 1.670757474145145e-07 6.7770865873805475 -0.9477217870248353 down TVATPLNQVANPNSAIFGGARPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVATPLNQVANPNSAIFGGARPR 23 1 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 34494700.0 8832700.0 12746000.0 12916000.0 False True 12098387.884742381 12182839.574614499 9865506.813369894 1.0 1.0069804085202643 0.8154397848172452 23.528311484799264 -6.898442720826691 0.9710746843353527 1.0083073926341946 0.7959592879241644 0.985775064177377 0.0105783377868045 0.11256014803903795 0.18396151750158965 0.00819359394925156 0.021156225905690756 1.263447729155535e-07 6.898442720826691 -0.21234810471003018 TVATPLNQVANPNSAIFGGARPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVATPLNQVANPNSAIFGGARPR 23 1 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 28053000.0 13813000.0 8721600.0 5518400.0 False True 11486121.519655075 8674615.00969795 6672271.925801265 1.0 0.755225773543657 0.5808986013584881 23.453388394401447 -7.4380162903119675 0.10796098927693347 1.4124671574740504 1.1452902645276957e-11 0.999997123383112 0.0002914975354686409 0.1270817024579243 0.008326168911624259 0.04172987432289249 0.06324881697199243 3.6474026532384925e-08 7.4380162903119675 -1.4124671574625975 TVATPLNQVANPNSAIFGGARPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVATPLNQVANPNSAIFGGARPR 23 1 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 98497000.0 37495000.0 22571000.0 38431000.0 False True 48538016.63694642 21314904.00849642 31436952.335359745 1.0 0.4391383390863942 0.6476769038690057 25.53261182242242 -10.136714444780061 5.255678596447819 1.0000132549240242 0.5434076214773884 0.8647149847100881 0.08513551256938662 1.3222968140170527e-05 2.1720451377739648e-06 0.0824344962456668 0.02747736852918063 7.299372973663316e-11 10.136714444780061 -0.45660563344663574 TVAVITSDGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVAVITSDGR 10 0 F2Z2Y6;O95777 F2Z2Y6 LSM8 U6 snRNA-associated Sm-like protein LSm8 0 4235800.0 2522700.0 1713100.0 0.0 False True 2442618.269356167 2397149.7636984843 0.0 1.0 0.9813853412020588 0.0 21.219996987191436 -7.038228206169587 1.0667933527696227 1.016381124260893 1.1389615570032117e-18 0.9871076331998856 0.053034259198404994 0.08618774640741936 0.18957416382611536 0.041787891900759724 0.0751995412282803 9.15739175592398e-08 7.038228206169587 -1.016381124260893 down TVAVITSDGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVAVITSDGR 10 0 F2Z2Y6;O95777 F2Z2Y6 LSM8 U6 snRNA-associated Sm-like protein LSm8 0 2522700.0 2522700.0 0.0 0.0 False True 2097736.8245590306 0.0 0.0 1.0 0.0 0.0 21.000402262625713 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 TVCIYGHLDVQPAALEDGWDSEPFTLVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVCIYGHLDVQPAALEDGWDSEPFTLVER 29 0 Q96KP4;J3QKT2;A0A087WYZ1;J3KSV5;J3QRD0;J3QKQ0;J3QLU1;J3QR27;J3QRH4;A0A087WVS2;J3KRD5 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 45598000.0 11850000.0 18377000.0 15371000.0 False True 17977316.351043098 15097480.76984364 12332915.112651365 1.0 0.839807259049966 0.6860264831427841 24.099674336008867 -6.971622778749902 0.21593637858027803 1.0746584729188753 0.44685325422534344 0.9999924227009237 0.0003528146841109559 0.07577957547568379 0.007114958707793045 0.004395223936440487 0.015723646202418836 1.0675229520416205e-07 6.971622778749902 -0.6278052186935319 TVDFTQDSNYLLTGGQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVDFTQDSNYLLTGGQDK 18 0 Q9Y3F4;Q9Y3F4-2 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 0 11277300.0 2031800.0 5749900.0 3495600.0 False True 2663709.4759791903 4892037.332934655 3133908.8441629107 1.0 1.8365506362649864 1.1765205148774243 21.345005309233205 -10.287568010019545 4.929507504348467 0.999844162808884 1.5065355755715215 0.4398675155988151 0.2694561687122224 0.00046163334920543543 6.671658440038757e-05 0.2609792482689178 0.08696660449611827 5.1574139423522394e-11 10.287568010019545 0.5066914127626375 TVDFTQDSNYLLTGGQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVDFTQDSNYLLTGGQDK 18 0 Q9Y3F4;Q9Y3F4-2 Q9Y3F4 STRAP Serine-threonine kinase receptor-associated protein 0 9089700.0 2031800.0 3388200.0 3669700.0 False True 2783011.367330442 3238498.120720917 2802992.4398438777 1.0 1.1636668677452773 1.0071796589651023 21.408215370756096 -10.875148514573329 2.7527489886540626 0.9612998964875996 1.0854232632057352 0.28434098484216175 0.06388563639610584 48261400.81225752 26000702.63063071 12123610.702190846 0.023379749268520867 1.3330654892127272e-11 10.875148514573329 0.12412336671813562 TVDGMQQEGTPYTGILYAGIMLTK ddPTM_RPMI8226_Bortezomib_8h_R1 2 TVDGMQQEGTPYTGILYAGIMLTK 24 0 P22102;P22102-2;F8WD69 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 111228000.0 25096000.0 56294000.0 29838000.0 False True 38072466.763356745 46247895.872970514 23940506.221539993 1.0 1.2147333704545327 0.6288141603837919 25.182244711179486 -6.807520847990435 1.4250108165205766 1.1173744096137186 0.6191424757340289 0.8532376734710276 0.09271924695265928 0.21019937502762995 0.8417354416504818 0.051169340286464624 0.11849924472027998 1.557683257586023e-07 6.807520847990435 -0.49823193387968967 TVDGMQQEGTPYTGILYAGIMLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TVDGMQQEGTPYTGILYAGIMLTK 24 0 P22102;P22102-2;F8WD69 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 72590800.0 25096000.0 21502500.0 25992300.0 False True 32487266.716116965 20305866.97278339 21261968.103519853 1.0 0.6250407936814713 0.6544708205006292 24.953371033271935 -10.394901927227872 6.601721204281024 1.0000364675428624 0.6397558070910518 0.9950194161360268 0.012014758137226925 6.449497054836417e-06 5.9113720983876e-07 0.011634413579389073 0.003877746514515815 4.028079865189231e-11 10.394901927227872 -0.3602806604518105 TVDGMQQEGTPYTGILYAGIMLTK(ub)NGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVDGMQQEGTPYTGILYAGIMLTKNGPK 28 1 P22102;P22102-2;F8WD69 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 9067400.0 2705000.0 1846300.0 4516100.0 True False 2619131.25564214 2583537.2183273085 3333197.9299040763 1.0 0.9864099833720993 1.27263493294721 21.32065693031817 -6.895751617385678 0.9876999534361074 0.9866734105114139 1.3002198135101883 0.9843326357401757 0.016502491062998337 0.11460169271264983 0.19556351974793773 0.012624013628957261 0.032199680045078366 1.271300982464245e-07 6.895751617385678 0.31354640299877445 TVDGPSGK(ub)LWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVDGPSGKLWR 11 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 53853700.0 14769000.0 24060000.0 15024700.0 True False 19362302.023199454 20470341.78514545 13470088.171099225 1.0 1.0572266541766764 0.6956862957183336 24.206747151948985 -6.866410764808719 1.1529814098108628 1.0317564056077984 0.6759142339509048 0.9609641297742784 0.03134974846981098 0.140339060326996 0.35094854883756665 0.021145309111654072 0.04977093849146692 1.3601576083634177e-07 6.866410764808719 -0.3558421716568936 TVDGPSGK(ub)LWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVDGPSGKLWR 11 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 80202000.0 32787000.0 19616000.0 27799000.0 True False 31746194.63169647 27448771.096088625 20517607.947876148 1.0 0.8646318531885661 0.6463013342515918 24.920080332789087 -6.964023932731979 0.3744325858455419 1.015968347780976 0.4873119307104198 0.9998915791089569 0.0015172505862163868 0.07829383123247895 0.01603792547131904 0.0028598317991067232 0.018499636275292223 1.086365755444806e-07 6.964023932731979 -0.5286564170705562 TVDGPSGK(ub)LWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVDGPSGKLWR 11 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 222371000.0 41113000.0 37158000.0 144100000.0 True False 62371426.762905985 30526864.583220907 115618571.8387263 1.0 0.48943668868219764 1.853710550477384 25.894381925537598 -6.8053513356834054 1.4339962944450309 0.7201774525518616 1.8751181725368076 0.8473269118652819 0.21990686001191848 0.21321636076095665 0.8649608491223281 0.12061210235255292 0.2796321479891334 1.5654841118872968e-07 6.8053513356834054 1.154940719984946 TVDGPSGK(ub)LWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVDGPSGKLWR 11 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 50888000.0 14769000.0 22097000.0 14022000.0 True False 20229498.41721788 21120681.47499265 10710292.3921549 1.0 1.0440536408463919 0.529439345022963 24.269957213471876 -6.886077296612264 1.045287177098153 1.0303064727487623 0.4884319080542628 0.9782672928943994 0.03433465821509524 0.12238450594195 0.24089075980347968 0.025147299780263373 0.06187079749989242 1.2999381918080747e-07 6.886077296612264 -0.5418745646944996 TVDGPSGK(ub)LWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVDGPSGKLWR 11 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 82493000.0 32787000.0 33535000.0 16171000.0 True False 27263843.210376564 33354340.2988237 19552281.33374389 1.0 1.223390995959407 0.7171505932920833 24.700485608223364 -6.786744478861531 1.509177890398741 1.1253850794846882 0.7122294351580675 0.7906328023776108 0.09478327352524496 0.24024752986191783 1.0810060489791409 0.04944270691925208 0.11604473180081044 1.6340130516831767e-07 6.786744478861531 -0.4131556443266208 TVDGPSGK(ub)LWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVDGPSGKLWR 11 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 141865000.0 41113000.0 35139000.0 65613000.0 True False 53221588.95838855 33183483.760336492 53672107.246232376 1.0 0.6234966751233432 1.0084649537276322 25.665508247630047 -10.893447831674317 11.077834195269283 1.0121477501355072 0.8159808144254878 0.23351662031914067 0.15716264162301713 0.04587095137392663 0.00044120900132797687 0.1480370972066769 0.050724024470992515 1.2780627238079517e-11 10.893447831674317 -0.19616693571001942 TVDLK(ub)PDWGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVDLKPDWGK 10 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 76150800.0 22166500.0 35082000.0 18902300.0 True False 29060496.160691332 29847902.348564923 16946471.319664903 1.0 1.0270954144595328 0.5831445969111684 24.792555999063165 -6.892378404217794 1.0081799459346454 1.0225116767526197 0.5431288292983966 0.982378373738933 0.02697345702035564 0.11723563779832692 0.21073237279093626 0.020318879221894123 0.05111021568405755 1.2812137644917178e-07 6.892378404217794 -0.4793828474542231 TVDLK(ub)PDWGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVDLKPDWGK 10 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 68291000.0 29268000.0 10311000.0 28712000.0 True False 28338903.36049323 14428236.071154648 21191465.858463254 1.0 0.5091317715303267 0.7477870822625375 24.756280595121332 -10.127898518939224 5.1927905635242855 1.0000096977114068 0.6284594268997812 0.763679203470081 0.09743062262079774 1.2407294724789124e-05 2.083759621907709e-06 0.09433958626685598 0.03144559823444966 7.449060148492686e-11 10.127898518939224 -0.3715502708116256 TVDLK(ub)PDWGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVDLKPDWGK 10 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 142970000.0 48602000.0 54875000.0 39493000.0 True False 73732787.28214319 45082127.50966807 31687191.23960316 1.0 0.6114257872438545 0.429757132581332 26.135802959661106 -13.999999999999998 0.1015398286927044 2.910630480581291 0.05189562442753803 0.9997859814087765 0.0034796490941852725 12.068888970757346 0.09520528308653861 4.813494233836012 0.3367178604666997 1.0000000000000041e-14 13.999999999999998 -2.858734856153753 TVDLK(ub)PDWGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVDLKPDWGK 10 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 73141000.0 22166500.0 29416000.0 21558500.0 True False 30362054.07713858 28116303.854296263 16466826.311244596 1.0 0.9260343118704449 0.5423488894858224 24.855766060586056 -6.938989085302871 0.6689118322776643 1.0043912961981614 0.44189056384888636 0.9980283239626503 0.008906942832736176 0.08823117857728853 0.05673483519789913 0.008605143404477229 0.03317291594743578 1.150829311245002e-07 6.938989085302871 -0.562500732349275 TVDLK(ub)PDWGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVDLKPDWGK 10 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 77262300.0 29268000.0 41720000.0 6274300.0 True False 24337638.7922439 41495246.079228364 7586227.120914554 1.0 1.7049824115415986 0.3117076058887105 24.53668587055561 -6.769145147561611 1.577741265991509 1.4047987819611296 0.3041251235789164 0.7272825027249982 0.2970489669492903 0.2678099623227368 1.3155323034221762 0.14841508705129855 0.35356509228953054 1.701589717204559e-07 6.769145147561611 -1.1006736583822132 TVDLK(ub)PDWGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVDLKPDWGK 10 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 117949900.0 48602000.0 59816000.0 9531900.0 True False 62916247.08864829 56487187.01751011 7797192.005553205 1.0 0.8978155823235975 0.12392970601960807 25.906929281753555 -6.981316167011146 0.7771715256737738 1.008198370620874 1.0409889034205236e-24 0.9966249372298083 0.022722777807440864 0.08254344768168001 0.07927032412981677 0.0208790030814217 0.06124806177743577 1.0439599381661789e-07 6.981316167011146 -1.008198370620874 down TVDLKPDWGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVDLKPDWGK 10 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 29191700.0 6504700.0 10975300.0 11711700.0 False True 8527724.691604408 9337828.021384312 10499885.63055921 1.0 1.0949964215633574 1.2312646116374284 23.023729432319442 -6.9659891112797006 0.3406502225994415 0.9853306454100831 1.3454634197811428 0.99993210268981 0.0007820618884346302 0.07762689918233609 0.013685272563180417 0.0019198137161646946 0.01178899775981803 1.0814610655716117e-07 6.9659891112797006 0.3601327743710597 TVDLKPDWGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVDLKPDWGK 10 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 34592900.0 12132100.0 6475300.0 15985500.0 False True 11746973.126275793 9060921.058243416 11798417.995279476 1.0 0.7713409199835336 1.0043794148884713 23.485785725829672 -11.04946605645471 10.171019649034184 1.3571742450766031 0.8878601674360017 0.2359105700925045 0.09513756715721244 0.046876160553199056 0.00022797923356607616 0.005603922891276839 0.0307055177665478 8.923473608594097e-12 11.04946605645471 -0.4693140776406014 TVDLKPDWGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVDLKPDWGK 10 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 96580900.0 18436800.0 67623000.0 10521100.0 False True 27969973.510625463 55555147.309089415 8441599.973438052 1.0 1.9862423998358336 0.30180936604145114 24.737375551700744 -6.747991590051057 1.6570544174670887 1.5813110079199681 0.2989231199193442 0.6403704333865057 0.41439289912583893 0.30356413216775285 1.639307881554012 0.19759507256248135 0.48076535169909185 1.7865221698455147e-07 6.747991590051057 -1.2823878880006239 TVDLKPDWGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVDLKPDWGK 10 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 35169100.0 6504700.0 12153600.0 16510800.0 False True 8909663.372907925 11616613.765419316 12611289.090599844 1.0 1.303821848167974 1.4154619049859554 23.086939493842333 -12.73594212272524 0.1544648093512251 1.4368724086046973e-10 1.5399572361063527 0.9995597015883737 0.003683741920975805 7.441161450332117 0.11274111331543607 2.3904969829875173 0.1048116835455751 1.8367831102560538e-13 12.73594212272524 1.5399572359626654 TVDLKPDWGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVDLKPDWGK 10 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 18449400.0 12132100.0 4988700.0 1328600.0 False True 10088378.693159157 4961824.882920577 1606404.1172476737 1.0 0.49183570857477305 0.15923313012991497 23.266191001263948 -8.316569299635567 0.3171657720132858 1.1397085950220553 4.622735879025435e-25 0.998658230303531 0.012664038642785654 0.11166135459400131 0.07939376503570372 0.09006512251378439 0.09322061630844766 4.824259940180993e-09 8.316569299635567 -1.1397085950220553 TVDLKPDWGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVDLKPDWGK 10 1 P31948;P31948-2;P31948-3;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 45200800.0 18436800.0 15225100.0 11538900.0 False True 23866801.04366059 14377809.80106146 9438938.599112246 1.0 0.602418806557255 0.39548402745073297 24.508501873793193 -10.931244755104817 0.12110166239532753 1.9804584964096055 2.595797860465244e-16 0.9998118399077789 0.0034409438447164428 3.1323128994576384 0.07090136467439387 1.1204592854592004 0.25932872377431276 1.1715349381597249e-11 10.931244755104817 -1.9804584964096053 TVDNFVALATGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVDNFVALATGEK 13 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 346044000.0 87424000.0 133330000.0 125290000.0 False True 114613710.6152204 113437683.7162694 112326192.6665441 1.0 0.9897392127640022 0.9800414982082211 26.77220439528305 -6.9718094464653655 0.21055898736327633 1.0050412507814934 0.9644685763070409 0.9999927608442218 2.1151929801860053e-05 0.07571974270312873 0.00688950035502388 0.0002891162829779203 0.0010036182315070127 1.0670642097372437e-07 6.9718094464653655 -0.040572674474452564 TVDNFVALATGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVDNFVALATGEK 13 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 304762000.0 109720000.0 64282000.0 130760000.0 False True 106236998.65769157 89950137.8262015 96510033.28408508 1.0 0.8466931385743652 0.9084408869178624 26.66271105333963 -10.28297317696064 4.6073242149402684 1.0000608588023365 0.87756701274567 0.8397938031296958 0.02520841270274134 1.5766497985111946e-05 2.453672099256709e-06 0.02442006309651515 0.008135980214956227 5.2122690229921506e-11 10.28297317696064 -0.12249384605666658 TVDNFVALATGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVDNFVALATGEK 13 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 491390600.0 73355000.0 354054600.0 63981000.0 False True 111284897.96884103 290870790.3887844 51335127.3061315 1.0 2.613748996474132 0.46129464323636227 26.72968258265254 -6.706061563465632 1.8092102785772797 1.9960617240371112 0.46690805899329535 0.4463969725029512 0.6804588787465826 0.3830469091786907 2.441530590396966 0.29958465944445933 0.7647524528168029 1.9676073515240925e-07 6.706061563465632 -1.529153665043816 TVDNFVALATGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVDNFVALATGEK 13 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 343346600.0 87424000.0 127770000.0 128152600.0 False True 119747015.34476653 122124698.92111191 97885595.26564468 1.0 1.0198558900988033 0.8174366182223407 26.835414456805943 -6.882798985088857 1.0641000711352844 1.0128268190422844 0.8023005301336713 0.9758725108253861 0.014150994253159792 0.12517809396858448 0.25756710484330914 0.010217263012915083 0.024892648694568073 1.3097880232649792e-07 6.882798985088857 -0.21052628890861314 TVDNFVALATGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVDNFVALATGEK 13 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 213830000.0 109720000.0 55406000.0 48704000.0 False True 91237041.42015171 55107516.88077001 58887781.21814741 1.0 0.604003768896854 0.6454372073176493 26.443116328773907 -10.117211961106992 7.818883486085897 1.000000046982729 0.6247204884671688 0.9909405640009905 0.016915130403329415 1.3870375373970122e-08 1.560653464145923e-09 0.016378006784205288 0.005459334862585134 7.63463078000632e-11 10.117211961106992 -0.3752795585155603 TVDNFVALATGEK(ub)GFGYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVDNFVALATGEKGFGYK 18 1 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 1 9014600.0 2258700.0 2474200.0 4281700.0 True False 2186998.804849872 3462160.9627825464 3160194.321753349 1.0 1.583064862726438 1.4449913345838719 21.060521001307055 -10.064181998217338 4.636380605900478 0.9999773823275737 1.5140280985301258 0.9486641359044998 0.05636828188158425 29555345.70174674 0.06641541624879015 7433.770564981717 0.02062867889059543 8.626169782351565e-11 10.064181998217338 0.514050716202552 TVDTK(ub)QAHELAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVDTKQAHELAK 12 1 P01111 P01111 NRAS GTPase NRas 1 3382790.0 1192600.0 1235200.0 954990.0 True False 1563510.1491548277 1050912.9747718906 856176.7957109326 1.0 0.6721497620849938 0.5475991289047585 20.576357153529766 -13.999999999999998 0.1341784932561248 2.5599509786600123 0.3820892329130602 0.9996271270309567 0.0036844597252251553 11.93248485919367 0.11430413956434105 4.8922568053634725 0.14746048811316867 1.0000000000000041e-14 13.999999999999998 -2.1778617457469522 TVDTK(ub)QAHELAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVDTKQAHELAK 12 1 P01111 P01111 NRAS GTPase NRas 1 3654100.0 1192600.0 1088500.0 1373000.0 True False 1633536.4488031704 1040406.4708118517 1048725.677822614 1.0 0.6369043504196785 0.6419971091498908 20.639567215052658 -9.872993061837693 5.671532180052495 1.0000001462542514 0.6394507297839481 0.9998503844980603 0.002079110048862808 3.846524023866273e-09 7.616328564627633e-10 0.0020130904569340647 0.0006710298823374667 1.3396980898819408e-10 9.872993061837693 -0.36054941647030325 TVEAEAAHGTVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVEAEAAHGTVTR 13 0 O75874 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 3555900.0 1244100.0 895900.0 1415900.0 False True 1204606.7264859092 1253637.5420567798 1045033.3139104947 1.0 1.0407027575828867 0.8675306977232946 20.200130789343746 -6.84475067137331 1.2600603096770229 1.021659809338574 0.861274858715231 0.9323216065913635 0.0192334474687562 0.16333128316173276 0.5016713596808822 0.011958018862439317 0.027595826390411027 1.4297145225948769e-07 6.84475067137331 -0.16038495062334301 TVEAEAAHGTVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVEAEAAHGTVTR 13 0 O75874 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 4234970.0 841870.0 1957100.0 1436000.0 False True 1153132.089681307 1870628.85073576 1096846.3753483426 1.0 1.6222155878540754 0.9511888405182443 20.13712635049536 -6.663091836347562 1.961670598158149 1.399479615095623 0.9539530835546928 0.24895956830126864 0.2647288998252398 0.4771392300381929 3.5327351749946954 0.10890068387168572 0.2936221376300466 2.1722417858626962e-07 6.663091836347562 -0.44552653154093025 TVEDLK(ub)NNESQWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVEDLKNNESQWK 13 1 O95155-3;O95155-2;O95155;O95155-4;K7EP75 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 27750800.0 7203500.0 12205400.0 8341900.0 True False 9443858.258793222 10384401.896276575 7478760.209155099 1.0 1.0995931548006461 0.7919178797703352 23.170944957897223 -6.819550674690582 1.3737241326541592 1.0537047854301662 0.785260226550013 0.883371146040109 0.04377619338447031 0.19406251103539626 0.7197072899534183 0.02504205555126951 0.057727573353797926 1.5151280040258005e-07 6.819550674690582 -0.2684445588801532 TVEDLK(ub)NNESQWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVEDLKNNESQWK 13 1 O95155-3;O95155-2;O95155;O95155-4;K7EP75 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 30594630.0 7410400.0 7621930.0 15562300.0 True False 7175160.908247884 10665406.396839868 11486066.771007326 1.0 1.4864344553694857 1.600809642861672 22.774579754970098 -11.750906682398146 0.24603678942634452 2.2905871940783972e-15 1.6543559901568439 0.9993427266112098 0.0066781435486548075 4.55029094736159 0.14140776748605516 2.416095673948731 0.05378936921977116 1.7745707449936265e-12 11.750906682398146 1.6543559901568416 TVEDLK(ub)NNESQWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVEDLKNNESQWK 13 1 O95155-3;O95155-2;O95155;O95155-4;K7EP75 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 90606300.0 18907500.0 35973100.0 35725700.0 True False 28684059.823404863 29553419.24588681 28664499.735869426 1.0 1.0303081024037117 0.9993180851087378 24.773745895802943 -6.651296099993737 2.004184526584035 1.0196474060995806 0.999449184021947 0.1991724122370817 0.012931860449564587 0.5053935112598311 3.8927072409293992 0.005230647161980547 0.01432223904804345 2.2320499025073153e-07 6.651296099993737 -0.020198222077633554 TVEDLK(ub)NNESQWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVEDLKNNESQWK 13 1 O95155-3;O95155-2;O95155;O95155-4;K7EP75 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 20674600.0 7203500.0 4402200.0 9068900.0 True False 9866828.617267845 4207696.247871324 6927012.599858344 1.0 0.4264487011061968 0.702050564427099 23.234155019420115 -10.463077113029172 6.206933430406387 1.0002025784039288 0.5642496327666588 0.7692190032799444 0.11251398954941363 0.00031555627626048604 2.72967709041384e-05 0.10899092999329592 0.03631373397835285 3.442887936546274e-11 10.463077113029172 -0.43595294563726994 TVEDLK(ub)NNESQWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVEDLKNNESQWK 13 1 O95155-3;O95155-2;O95155;O95155-4;K7EP75 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 30346500.0 7410400.0 10019200.0 12916900.0 True False 6162075.936382541 9965224.580944518 15617764.069002293 1.0 1.6171862670674295 2.5344971776136096 22.554985030404374 -6.96540948091502 0.35095339721820007 0.9123197206585141 3.270362451621734 0.9999213394788032 0.005591393057428191 0.07782228147705261 0.014371517826499845 0.012561320955194001 0.07879580244769609 1.0829053993006692e-07 6.96540948091502 2.35804273096322 TVEDLK(ub)NNESQWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVEDLKNNESQWK 13 1 O95155-3;O95155-2;O95155;O95155-4;K7EP75 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 64937200.0 18907500.0 26004700.0 20025000.0 True False 24476131.472544715 24557515.585031494 16380655.473851277 1.0 1.0033250398486406 0.6692501832744987 24.544872217895392 -6.904651380017172 0.9313818806183681 1.012173250338005 0.63067201161401 0.9887420189073612 0.016627134208361267 0.10806237647816848 0.15873509077603032 0.013262664237418169 0.03538691700332863 1.245514018542482e-07 6.904651380017172 -0.381501238723995 TVEEEDQIFLDGQENK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVEEEDQIFLDGQENKR 17 1 Q96HA1-2;A8CG34-2;Q96HA1-3;A8CG34;Q96HA1;C9JER0;C9J370;A0A0J9YWR1;Q6PJE2-5;Q6PJE2 Q96HA1-2 POM121;POM121C;POMZP3 Nuclear envelope pore membrane protein POM 121;Nuclear envelope pore membrane protein POM 121C;POM121 and ZP3 fusion protein 1 28736200.0 8219200.0 10114000.0 10403000.0 True False 10639916.424653685 9551147.009079475 8509760.74379401 1.0 0.8976712436338853 0.7997958258465353 23.34298348288793 -6.9716665424827 0.21468498720373722 1.048277585650597 0.6464426431074215 0.9999926219991058 0.00022195032391099823 0.07576553271074006 0.007062149695667639 0.0028247812310742103 0.010035153707925383 1.0674153834738983e-07 6.9716665424827 -0.40183494254317553 TVEGVLIVHEHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVEGVLIVHEHR 12 0 O43809;H3BND3;H3BV41 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 7811000.0 2440000.0 3378000.0 1993000.0 False True 3198863.6289936113 2874015.5673408727 1786783.4782059388 1.0 0.8984489183257436 0.5585681934081308 21.609128059443208 -6.9489683477298785 0.5700563678187552 1.0042327824180879 0.43625795602891215 0.9991178224569953 0.005606626686599263 0.08390265569595756 0.03769722996820098 0.005939495925751423 0.028319137221125775 1.1246869404645368e-07 6.9489683477298785 -0.5679748263891757 TVEGVLIVHEHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVEGVLIVHEHR 12 0 O43809;H3BND3;H3BV41 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 6474650.0 2381600.0 824850.0 3268200.0 False True 2305997.4116219287 1154216.9065359258 2412160.3761016172 1.0 0.5005282749749943 1.0460377639387801 21.136959462954664 -6.665894787926118 1.9521466155106701 0.6800644881827953 1.0437864161120536 0.2608794618237016 0.21236874769691064 0.47062516770218993 3.4536772913944844 0.08770883430681628 0.23557875641256898 2.158267207103995e-07 6.665894787926118 0.3637219279292583 TVEGVLIVHEHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVEGVLIVHEHR 12 0 O43809;H3BND3;H3BV41 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 20628900.0 2215700.0 13570000.0 4843200.0 False True 3361378.889367611 11148327.477106087 3885939.397150028 1.0 3.3165935302233853 1.1560551562460442 21.680621739462907 -6.629685390586512 2.081428605512541 2.5265620977309573 1.164725818215869 0.11637136132262216 0.993776117014635 0.5598686090976975 4.62181053702343 0.39054025816056814 1.101008755360548 2.3459276249569316e-07 6.629685390586512 -1.3618362795150882 TVEGVLIVHEHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVEGVLIVHEHR 12 0 O43809;H3BND3;H3BV41 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 5965400.0 2440000.0 1919900.0 1605500.0 False True 3342133.9385206583 1835072.4697397125 1226313.9663104182 1.0 0.5490720909144586 0.3669254401136378 21.6723381209661 -13.999999999467885 0.12486102793535211 3.143809222213244 0.09437558442836669 0.9996694622080803 0.0048379331048902414 11.947708744077705 0.10934474040891576 6.318431235008106 0.24202131680474936 1.0000000012252397e-14 13.999999999467885 -3.049433637784877 TVEGVLIVHEHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVEGVLIVHEHR 12 0 O43809;H3BND3;H3BV41 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 3972880.0 2381600.0 889920.0 701360.0 False True 1980405.922769168 885125.82432471 848011.1332777571 1.0 0.4469416164374289 0.4282006650899112 20.91736473838894 TVEGVLIVHEHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVEGVLIVHEHR 12 0 O43809;H3BND3;H3BV41 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 0 13126700.0 2215700.0 6356700.0 4554300.0 False True 2868267.327976585 6002944.057011607 3725464.131064211 1.0 2.0928816496495726 1.2988552687285024 21.451748061555357 -10.031290367444251 4.403267160472267 0.9999644067255903 1.695868458756806 0.505942217767664 0.3241599129196181 172518637.3229759 372915223.80409664 96700.82754872416 0.12813550382444636 9.304855487664585e-11 10.031290367444251 0.6959040520312157 TVEIVHIDIADR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVEIVHIDIADR 12 0 P48739;P48739-2;P48739-3;A0A0A0MSW4;B3KYB6;B3KYB7 P48739 PITPNB Phosphatidylinositol transfer protein beta isoform 0 4342500.0 849100.0 1449700.0 2043700.0 False True 1113178.3226960963 1233410.4108863394 1832237.5285546798 1.0 1.1080079316484024 1.6459514986934314 20.08625328928371 -6.939892529844101 0.6605675847487372 0.993950548018509 1.7905578741324562 0.9981497303520618 0.012152058380198713 0.0878157711362722 0.05483423309412563 0.011819477163889845 0.04632171243167613 1.1484377778064187e-07 6.939892529844101 0.7966073261139471 TVEIVHIDIADR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVEIVHIDIADR 12 0 P48739;P48739-2;P48739-3;A0A0A0MSW4;B3KYB6;B3KYB7 P48739 PITPNB Phosphatidylinositol transfer protein beta isoform 0 6357600.0 2100000.0 1958000.0 2299600.0 False True 2033336.6494818833 2739839.6108351103 1697265.7734787564 1.0 1.3474599061268344 0.8347195108646857 20.955417664157476 -6.7242238139892665 1.7442689221246668 1.210437114136693 0.83533232246379 0.5322568840285916 0.14614241292741256 0.34719811523854793 2.0666323643619764 0.06647088808311359 0.1660339770275021 1.8870186219979095e-07 6.7242238139892665 -0.375104791672903 TVEIVHIDIADR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVEIVHIDIADR 12 0 P48739;P48739-2;P48739-3;A0A0A0MSW4;B3KYB6;B3KYB7 P48739 PITPNB Phosphatidylinositol transfer protein beta isoform 0 5047900.0 849100.0 1658500.0 2540300.0 False True 1163035.2160647092 1585221.9860739154 1940333.4591207472 1.0 1.3630042875552244 1.6683359474583532 20.149463350806602 -6.973123276959842 0.16754024509495635 0.7211287451485651 2.31836936334255 0.9999976217180958 0.00042125823317023826 0.07530164869063959 0.0052123281237658105 0.013163130874977893 0.03567107217170926 1.0638409980406767e-07 6.973123276959842 1.5972406181939849 TVENIK(ub)DPLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVENIKDPLFR 11 1 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6I5 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 1 6579600.0 1769300.0 1847600.0 2962700.0 True False 1713134.539965856 2585356.315106718 2186679.9909051647 1.0 1.5091379309638144 1.2764204677986044 20.708207026361716 -10.102963592645562 4.419079286256433 0.9999616063754834 1.3927791993639291 0.791588480927656 0.09500650661193485 66152143.75438905 2.2220019507420763 28718.38803888153 0.0325232542209704 7.889262513479967e-11 10.102963592645562 0.39281759298844576 TVENIK(ub)DPLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVENIKDPLFR 11 1 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6I5 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 1 6824600.0 1769300.0 2905200.0 2150100.0 True False 1471251.3432799345 2889549.1109629488 2599675.9690608336 1.0 1.9640077979613815 1.7669829026393582 20.488612301795992 -10.211265843812114 4.71699482085881 0.9998352559230778 1.865495350304192 0.9625877084339653 0.0804350767071518 56606571.0361067 30.308091800648597 101288.03568692981 0.027535066202508854 6.148004209519293e-11 10.211265843812114 0.8656600943811142 TVEQTATTTNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVEQTATTTNK 11 0 P08579 P08579 SNRPB2 U2 small nuclear ribonucleoprotein B 0 11004500.0 1624900.0 5033200.0 4346400.0 False True 2130259.635553985 4282266.179259938 3896676.2216127897 1.0 2.0102085716637603 1.8292024862027858 21.02259784583101 -10.21146173138664 4.608830846585363 0.999786494384927 1.9197055289403357 0.9717698336468623 0.07389542497712116 0.00016215035877236865 2.774252436784054e-05 0.0715651689598911 0.023849645854705934 6.145231790984489e-11 10.21146173138664 0.9199190345554088 TVEQTATTTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVEQTATTTNK 11 0 P08579 P08579 SNRPB2 U2 small nuclear ribonucleoprotein B 0 10903200.0 1624900.0 4314100.0 4964200.0 False True 2225669.4412714024 4123488.7971790633 3791758.2009082427 1.0 1.8526959667575529 1.703648408248001 21.085807907353903 -10.148889489231001 4.518456384836561 0.9998902368644665 1.7781721875216407 0.9732223977152668 0.060848411025608895 42560777.58759195 10.694268363976763 49156.96362482547 0.020830029556995037 7.097583504156182e-11 10.148889489231001 0.7782819506571742 TVEQTATTTNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVEQTATTTNK 11 0 P08579 P08579 SNRPB2 U2 small nuclear ribonucleoprotein B 0 5261920.0 2740200.0 1915800.0 605920.0 False True 2278597.711442758 1905479.205143474 732615.0705424579 1.0 0.8362508202191454 0.3215201467391022 21.119714807250414 -6.950396207592121 0.554475083612374 1.0069369420684582 0.12646629741196794 0.9992320220068464 0.008011055986584789 0.0833270010596586 0.03530669483083608 0.008645859047528537 0.042738588476056806 1.1209953017467604e-07 6.950396207592121 -0.8804706446564903 down TVESEAASYLDQISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVESEAASYLDQISR 15 0 P61289;P61289-3;P61289-2;K7ESG5;K9J957;B3KQ25;K7ENH2;A0A087WTV2 P61289 PSME3 Proteasome activator complex subunit 3 0 13981800.0 7368900.0 1821400.0 4791500.0 False True 7134978.303031933 2548694.5184755228 3536462.4080811697 1.0 0.3572112500177446 0.4956514593153546 22.766477611897557 -9.960757279139687 7.100983167496637 1.0000000239298856 0.42643135466839416 0.9581358712128177 0.05651797877721145 2.144871836285181e-08 3.1005425344493487e-09 0.054723300087673295 0.0182410992137866 1.0945679334334893e-10 9.960757279139687 -0.5735686692614914 TVETK(ub)ATQNFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVETKATQNFK 11 1 G5E9G4;Q9ULT0;Q9ULT0-4;H7C055 G5E9G4 TTC7A Tetratricopeptide repeat protein 7A 1 3830210.0 667710.0 1044000.0 2118500.0 True False 875374.2761128371 888239.2694801257 1899297.9420869455 1.0 1.0146965631939935 2.1696981438852827 19.73954046377164 -6.909674258315793 0.897933546863178 0.9638689636207357 2.3179356345554227 0.9907983930865528 0.05256400908372143 0.1046344333452469 0.1399325247867782 0.04296559271500481 0.11834103217803499 1.2311918775211006e-07 6.909674258315793 1.354066670934687 up TVETK(ub)ATQNFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVETKATQNFK 11 1 G5E9G4;Q9ULT0;Q9ULT0-4;H7C055 G5E9G4 TTC7A Tetratricopeptide repeat protein 7A 1 6345500.0 1237300.0 2797100.0 2311100.0 True False 1028869.7716838659 2782031.4671191196 2794340.3246809426 1.0 2.70396851349418 2.7159319882706607 19.97262895521424 -10.731620230470634 0.8710731706391034 8.057969386165236e-08 2.71309754247417 0.9999928926223018 0.002149009426261092 2.466376585500645 0.48122778816125067 5.244398061136782 0.0016580996636916332 1.8551531560870162e-11 10.731620230470634 2.713097461894476 TVETK(ub)ATQNFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVETKATQNFK 11 1 G5E9G4;Q9ULT0;Q9ULT0-4;H7C055 G5E9G4 TTC7A Tetratricopeptide repeat protein 7A 1 10673600.0 4215900.0 2367600.0 4090100.0 True False 5457565.657813103 2235840.9787123343 3345743.7679699985 1.0 0.4096773394767103 0.6130469109758121 22.37982615113787 -10.101887245619075 5.004138521515189 1.0000154776818353 0.511362125225351 0.8850224038770593 0.08302527990299163 1.4503096984068063e-05 2.603058613287626e-06 0.0803914543970081 0.02679629386399916 7.908839358199874e-11 10.101887245619075 -0.48865335245648434 TVFAEHISDECK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVFAEHISDECK 12 0 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 48250400.0 9649600.0 20805400.0 17795400.0 False True 12650719.046859324 17701315.41881401 15954102.713530343 1.0 1.3992339370787428 1.261122206131921 23.592716051965624 -10.056035868476922 5.074147596903066 0.9999946428365493 1.330178071606764 0.8839952239999692 0.05638387805702293 3.417171286148927e-06 6.356237576603693e-07 0.0545943412837699 0.018197818391739475 8.789499211654851e-11 10.056035868476922 0.33018342877021467 TVFAEHISDECK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVFAEHISDECK 12 0 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 15629600.0 7298500.0 3697200.0 4633900.0 False True 7066813.112496919 5173511.240643289 3420142.575979833 1.0 0.7320854759119745 0.48397241041109024 22.752628325611482 -6.972047178661866 0.2034324803478259 1.1412974198947934 0.06788441902702463 0.9999942542649032 0.0005050661685911718 0.07564385440599067 0.006596546784598825 0.007832404567946413 0.02611596445056168 1.0664802601113358e-07 6.972047178661866 -1.0734130008677687 down TVFAEHISDECK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVFAEHISDECK 12 0 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 103632100.0 11916000.0 83321000.0 8395100.0 False True 18077443.176289435 68451716.56005567 6735804.805296956 1.0 3.7865817578581944 0.3726082687474138 24.107687305585415 -6.689703144585227 1.8674339429576916 2.747502228157052 0.3844421299432675 0.3690335647360916 1.1786003460224936 0.41731829366631024 2.8213668606515383 0.5049376166492627 1.3154026257884546 2.043134020794046e-07 6.689703144585227 -2.363060098213784 TVFAEHISDECK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVFAEHISDECK 12 0 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 50559300.0 9649600.0 19258600.0 21651100.0 False True 13217317.890634812 18407691.37232626 16537556.098401425 1.0 1.3926949116786476 1.2512036280915346 23.655926113488515 -10.103716529982256 5.161018122254429 0.999992378293635 1.3219492698856148 0.8734699396991848 0.05776357464180208 5.065933956901427e-06 8.796346987969953e-07 0.055930663669315185 0.018643113550163248 7.875596730636662e-11 10.103716529982256 0.3219568915919798 TVFAEHISDECK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVFAEHISDECK 12 0 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 12222800.0 7298500.0 1640100.0 3284200.0 False True 6069026.128372013 1631264.4557656394 3970911.0355749005 1.0 0.2687852089052084 0.6542913066416602 22.53303360104576 -10.71730697612905 6.825334089179316 1.0063340358842099 0.46153825777612784 0.7223204142707891 0.15738220536430136 0.015196879169578483 0.0006294264227560477 0.1526629839386011 0.050794888363777914 1.91731303062181e-11 10.71730697612905 -0.5447957781080821 TVFAEHISDECK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVFAEHISDECK 12 0 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 38162700.0 11916000.0 14072200.0 12174500.0 False True 15425496.899476023 13289069.69954204 9958865.920918971 1.0 0.8615002671319746 0.6456107045250035 23.878813627677864 -6.964610614761768 0.3646733783106078 1.0176377140887947 0.48202091346604886 0.9999048908822162 0.001422122716036364 0.07809334153229497 0.015327363361106365 0.002870768558769572 0.018389458018648545 1.084899190722953e-07 6.964610614761768 -0.5356168006227457 TVFAEHISDECK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVFAEHISDECKR 13 1 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 1 17307100.0 4332300.0 6185100.0 6789700.0 True False 5679687.254052878 5262307.189330965 6087166.975401343 1.0 0.926513548008461 1.071743337814542 22.437380060770842 -6.769188059804287 1.5780177072287451 0.9578054371634652 1.072526371148029 0.727274838156776 0.030963718412085492 0.26774773493953985 1.3157658071128713 0.015469055798347509 0.03684343320271282 1.7014215929787895e-07 6.769188059804287 0.11472093398456384 TVFAEHISDECK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVFAEHISDECKR 13 1 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 1 8128200.0 3301700.0 3110300.0 1716200.0 True False 3196889.340759204 4352259.010000232 1266675.7351036032 1.0 1.3614043359307046 0.39622132644816244 21.608237375907116 -6.805274993443533 1.4341557044389266 1.198090659542365 0.38107732767946795 0.8471691093152925 0.15565272890987691 0.213313889727101 0.8655356959544291 0.0853589547417636 0.19792196809054047 1.5657593239229341e-07 6.805274993443533 -0.8170133318628972 down TVFAEHISDECK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVFAEHISDECKR 13 1 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 1 64004800.0 9143300.0 10288500.0 44573000.0 True False 13871054.564767301 8452436.790582592 35763127.012960106 1.0 0.6093579079453638 2.5782558093166914 23.725574138789046 -6.855149011653592 1.2099335641132194 0.7902137049632391 2.665162491660991 0.9474699424959596 0.19507795725318972 0.15188835822888438 0.4253002782598489 0.12597173212992271 0.2926433367384417 1.3958893324826717e-07 6.855149011653592 1.8749487866977521 up TVFAEHISDECK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVFAEHISDECKR 13 1 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 1 15712800.0 4332300.0 3365900.0 8014600.0 True False 5934068.386005348 3217183.408457156 6121716.545868264 1.0 0.5421547577787312 1.0316221768366298 22.500590122293733 -11.81102996700576 13.794366594874575 0.9033139701472198 0.8081996205768512 0.0 0.22911779591406065 0.0 0.0 0.0 0.06651811532756022 1.545147818217994e-12 11.81102996700576 -0.09511434957036857 TVFAEHISDECK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVFAEHISDECKR 13 1 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 1 14815200.0 3301700.0 2704800.0 8808700.0 True False 2745509.8401104133 2690228.705539234 10650558.443172945 1.0 0.9798648929377153 3.8792643492199694 21.388642651341392 -6.905333671864665 0.9269103904899778 0.8964510252476191 4.218864403241342 0.989038705688714 0.14260344064046473 0.10758572391363311 0.15609701326607953 0.11412201457446586 0.30572366218686914 1.243558808633923e-07 6.905333671864665 3.3224133779937226 up TVFAEHISDECK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVFAEHISDECKR 13 1 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 1 67787400.0 9143300.0 8755100.0 49889000.0 True False 11836182.091387974 8267870.988648567 40809713.904367864 1.0 0.6985251599554457 3.4478781746743388 23.496700460881495 -6.879718718515661 1.0814122188376143 0.8138577624072121 3.6416401016577504 0.9734558672891269 0.2005861899056328 0.12787743604910634 0.2738191051409879 0.14292409029937633 0.3453684360123546 1.319110816452398e-07 6.879718718515661 2.8277823392505383 up TVFAEHISDECKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVFAEHISDECKR 13 1 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 20084600.0 4839900.0 9048700.0 6196000.0 False True 6345155.769658276 7698669.231556336 5554897.356228802 1.0 1.2133144576797292 0.875454844275315 22.597224151098203 -6.736061300499166 1.70100972499167 1.1274972529075087 0.8754183634411099 0.58715784231422 0.0896381293726113 0.3250003492721738 1.8448045560968525 0.04171440727380151 0.10281355889371033 1.8362791349612095e-07 6.736061300499166 -0.2520788894663988 TVFAEHISDECKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVFAEHISDECKR 13 1 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 56431100.0 4749800.0 46656000.0 5025300.0 False True 7205793.856893204 38329872.27500821 4032047.252332767 1.0 5.319312907951301 0.5595562865673199 22.780725949108323 -6.667793787406418 1.9451321639552823 3.762225168062144 0.5789628795885251 0.2693089318209333 1.8356915698520957 0.4662213447927347 3.3985912163028633 0.7603240191713608 2.037302905285776 2.148850553545292e-07 6.667793787406418 -3.1832622884736193 TVFAEHISDECKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVFAEHISDECKR 13 1 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 17845900.0 4839900.0 6015700.0 6990300.0 False True 6629341.823379569 5749906.48274034 5339335.109747572 1.0 0.8673419829495378 0.8054095341587976 22.660434212621094 -13.999999999999941 0.1017786423491876 1.6518593074907921 0.6770631546617845 0.9997847735925164 0.0011908194974362657 12.067139461848498 0.09536398758741643 1.6449173404422341 0.11435721293498664 1.000000000000135e-14 13.999999999999941 -0.9747961528290077 TVFAEHISDECKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVFAEHISDECKR 13 1 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2;F8WCR1 P39023 RPL3 60S ribosomal protein L3 0 18498900.0 4749800.0 9043300.0 4705800.0 False True 6148709.732555481 8540032.405300412 3849392.685585488 1.0 1.3889145490286574 0.6260488546408634 22.551852271200772 -6.768124568724964 1.5817301235742622 1.2236037034147567 0.6220679028480097 0.7233153671612156 0.16382977164299764 0.2694649290223627 1.3302185081869504 0.081657265845687 0.19470683295923105 1.7055931034136476e-07 6.768124568724964 -0.6015358005667469 TVFCMQLAAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVFCMQLAAR 10 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;Q5QP23;Q5QP22;Q86U06-4;Q86U06-5;Q86U06-2;Q86U06;Q86U06-3 Q14498-3;Q86U06-4 RBM39;RBM23 RNA-binding protein 39;Probable RNA-binding protein 23 0 102329000.0 0.0 44330000.0 57999000.0 False True 0.0 36418965.148129135 46535472.22813526 0.0 TVFCMQLAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVFCMQLAAR 10 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;Q5QP23;Q5QP22;Q86U06-4;Q86U06-5;Q86U06-2;Q86U06;Q86U06-3 Q14498-3;Q86U06-4 RBM39;RBM23 RNA-binding protein 39;Probable RNA-binding protein 23 0 84533000.0 0.0 52703000.0 31830000.0 False True 0.0 49770031.72033962 26037266.603380095 0.0 TVFDNFFIK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVFDNFFIKK 10 1 Q9H040 Q9H040 SPRTN SprT-like domain-containing protein Spartan 1 19127000.0 5167400.0 5175100.0 8784500.0 True False 5003363.715491758 7241544.417789974 6483575.920648873 1.0 1.4473351987920062 1.2958434144161817 22.254466901019843 -10.04024690078404 4.876561262877796 0.9999922416686894 1.3715893066090312 0.8891608136836171 0.06184626200779596 5.216856028750924e-06 1.0267481264676652e-06 0.05988363537975906 0.019960795229352228 9.114924993692607e-11 10.04024690078404 0.37159706494034184 TVFDNFFIK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVFDNFFIKK 10 1 Q9H040 Q9H040 SPRTN SprT-like domain-containing protein Spartan 1 15405400.0 5167400.0 5927500.0 4310500.0 True False 4296922.054634453 5895567.380983378 5211805.6204998465 1.0 1.3720442926407528 1.2129160255254443 22.03487217645412 -10.324945750316532 5.58140007508963 0.9999500714940676 1.292480159083102 0.8183271349332047 0.06496384301431424 4.0368148862195076e-05 4.882449604745693e-06 0.06291168198338463 0.020966990175004162 4.732103661119037e-11 10.324945750316532 0.29253008758903454 TVFGVEPDLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVFGVEPDLTR 11 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 39666700.0 6279700.0 12546000.0 20841000.0 False True 8232747.512701296 10674185.703924965 18684573.240988456 1.0 1.2965520547614358 2.2695428485037734 22.972942550572842 -6.949422377694458 0.5651509808725006 0.987601207587078 2.6254073913819505 0.9991551599472283 0.015761340584917276 0.08371855501496459 0.03692892573573528 0.016792040640914337 0.08097549227231289 1.123511759192913e-07 6.949422377694458 1.6378061837948725 up TVFGVEPDLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVFGVEPDLTR 11 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 31677100.0 10770000.0 5244100.0 15663000.0 False True 10428112.24519994 7338096.477620236 11560390.420072077 1.0 0.7036840710069996 1.108579400398507 23.31397468103556 -6.710509301543666 1.7931558538621857 0.8179287647258934 1.1076520917798867 0.46761532554555796 0.12485584891581582 0.37405930940396065 2.3448265294688 0.055400812668158037 0.14066953406184673 1.947559337457072e-07 6.710509301543666 0.2897233270539933 TVFGVEPDLTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVFGVEPDLTR 11 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 111925000.0 17048000.0 79604000.0 15273000.0 False True 25863062.375745382 65398044.25110917 12254284.855606304 1.0 2.528627248428247 0.4738141476663833 24.624389775118587 -6.707570084334181 1.8045683335668354 1.9421255205063055 0.47911848213834424 0.4532713024847643 0.6444070716032473 0.3799595758097651 2.4105691812073484 0.2843844822078399 0.7244172094609409 1.960784728027211e-07 6.707570084334181 -1.4630070383679612 TVFGVEPDLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVFGVEPDLTR 11 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 34449700.0 6279700.0 13827000.0 14343000.0 False True 8601474.79251154 13216077.420225538 10955478.803357428 1.0 1.5364896996188933 1.273674464859827 23.036152612095734 -10.00628626346655 4.3044822178731605 0.9999792349203322 1.4050820820580727 0.7600509727273467 0.10729387068119996 74577755.84210107 191148760.95269203 25078.617829824867 0.03926553886398919 9.85629597671554e-11 10.00628626346655 0.4051028471377405 TVFGVEPDLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVFGVEPDLTR 11 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 20567800.0 10770000.0 5962000.0 3835800.0 False True 8955732.19189786 5929881.52263565 4637848.045264657 1.0 0.6621325197732398 0.5178636370413645 23.094379956469837 -13.999999999998693 0.11622555044235988 2.6159109915116656 0.2754397968711491 0.999711645196575 0.0034310349479880716 11.979784528660431 0.10441445897302845 4.495329507405219 0.21511914929553705 1.0000000000030104e-14 13.999999999998693 -2.3404711946405166 TVFGVEPDLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVFGVEPDLTR 11 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 47440000.0 17048000.0 15927000.0 14465000.0 False True 22068972.06631982 15040648.449041795 11832518.42343365 1.0 0.6815291805999347 0.536160831953367 24.395516097211036 -13.999999999999863 0.10550607578007055 2.5505167456357642 0.25136785825721203 0.9997659062496771 0.002963738626895901 12.040934222870955 0.09780075454745928 4.012905948545701 0.2533213981184644 1.0000000000003149e-14 13.999999999999863 -2.299148887378552 TVFSDYLHPQYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVFSDYLHPQYK 12 0 Q9ULG6-4;Q9ULG6-2;Q9ULG6;Q9ULG6-5;H3BN32 Q9ULG6-4 CCPG1 Cell cycle progression protein 1 0 8275000.0 2544100.0 1330900.0 4400000.0 False True 2463338.9380699317 1862335.3105518105 3247508.0028294185 1.0 0.7560207333916388 1.318335837850189 21.232183715484524 -6.788832049218704 1.5014700771193896 0.8634310109078349 1.3240857608830912 0.797363415389083 0.10363943195928339 0.23710365514313403 1.0560765968211883 0.054339983750623995 0.12730642479642656 1.6261775111031644e-07 6.788832049218704 0.46065474997525624 TVGAALDILCPSGPIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVGAALDILCPSGPIK 16 0 E7EQ29;P16278-2;P16278-3;P16278 E7EQ29 GLB1 Beta-galactosidase 0 1025700.0 0.0 0.0 1025700.0 False True 0.0 0.0 783450.7849545911 0.0 TVGATALPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVGATALPR 9 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 9555300.0 1990200.0 4119900.0 3445200.0 False True 2609171.4731242186 3505226.979244423 3088723.7526919735 1.0 1.3434253039135327 1.1837948500155644 21.315160329614777 -10.474386494907526 5.762917192284533 0.9997534557362666 1.2636100769645486 0.7842996813849299 0.06516885990981668 0.00020662386575897356 1.8845273099579823e-05 0.06315781260205411 0.021033159093503596 3.354389616899782e-11 10.474386494907526 0.263856621228282 TVGATALPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVGATALPR 9 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 36506300.0 6151200.0 26170000.0 4185100.0 False True 9331820.112956647 21499759.032856736 3357913.1506055053 1.0 2.3039191468131355 0.3598347492728941 23.153727066461254 -6.725984341509798 1.7378460773396485 1.7881896454742003 0.36181138724588957 0.540533912102422 0.5483324942828742 0.34383356362454354 2.032418632482065 0.2502336225722771 0.62378680486608 1.8793845768041332e-07 6.725984341509798 -1.4263782582283109 TVGATALPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVGATALPR 9 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 5623100.0 1990200.0 0.0 3632900.0 False True 2726030.723132714 0.0 2774883.8419240876 1.0 0.0 1.017920971461111 21.37837039113767 -12.077070669639234 14.641971176329502 0.8843226012480259 0.5580644371575108 0.0 0.4892889364055269 0.0 0.0 0.0 0.1407367953692362 8.373930080563348e-13 12.077070669639234 -0.3262581640905151 TVGTPIASVPGSTNTGTVPGSEK(ub)DSDSMETEEK ddPTM_RPMI8226_Bortezomib_1h_R1 2 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEK 33 1 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 304610000.0 67973000.0 116663000.0 119974000.0 True False 89113261.25146838 99257335.1488122 107560241.35187119 1.0 1.1138334940825283 1.2070060038353592 26.40913680435507 -6.973413031599509 0.15647485356149649 0.9010141316152617 1.4222897322857075 0.9999982414087384 0.00011210745005230452 0.07521003200896202 0.004813135413245977 0.0044614854799862975 0.01132972389749689 1.0631314563127575e-07 6.973413031599509 0.5212756006704459 TVGTPIASVPGSTNTGTVPGSEK(ub)DSDSMETEEK ddPTM_RPMI8226_Bortezomib_2h_R1 2 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEK 33 1 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 347662800.0 100506000.0 129773800.0 117383000.0 True False 97315492.04420295 181593155.10142663 86636870.88548301 1.0 1.8660251444748674 0.8902680248087379 26.53616615592125 -6.6725224745094875 1.9281253295216372 1.5515837626608833 0.8941452889609172 0.290285888079434 0.3676579332275296 0.45542290007863995 3.2664333391261975 0.15336666502289856 0.4084598423485294 2.1255803447135145e-07 6.6725224745094875 -0.6574384736999661 TVGTPIASVPGSTNTGTVPGSEK(ub)DSDSMETEEK ddPTM_RPMI8226_Bortezomib_8h_R1 2 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEK 33 1 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 1015635000.0 229010000.0 414364000.0 372261000.0 True False 347424912.8736183 340417506.7592915 298683450.1822074 1.0 0.9798304443502132 0.8597064836592722 28.372125968502857 -6.9359950647086075 0.6958544783282976 1.0014861608220271 0.8308067976721293 0.9975903905464536 0.0030400409775809944 0.08964279671279209 0.0632987233505009 0.0028760803813737052 0.01053413180668006 1.1587905244928432e-07 6.9359950647086075 -0.17067936314989784 TVGTPIASVPGSTNTGTVPGSEK(ub)DSDSMETEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEK 33 1 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 312988000.0 67973000.0 121551000.0 123464000.0 True False 93104455.00125606 116180474.90459494 94304346.02089658 1.0 1.247850867104346 1.0128875790060134 26.472346865877963 -10.916054996787492 2.9068890435400534 0.9256749380266438 1.1303692231166116 0.2910200029571196 0.09592336097586168 24055292.08014191 171899.6104699265 11965031.73596877 0.032837118525350956 1.2132352029599167e-11 10.916054996787492 0.2046942850899678 TVGTPIASVPGSTNTGTVPGSEK(ub)DSDSMETEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEK 33 1 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 314206000.0 100506000.0 135016000.0 78684000.0 True False 83575192.17074159 134288642.00942215 95136460.60628921 1.0 1.6068002779470076 1.1383337343924773 26.316571431355527 -10.436112037926556 4.936817968572066 0.9993870966481607 1.3725670061697732 0.45749943054621867 0.19125066554579515 0.00129222024072177 0.00014759851024180503 0.18547320236155912 0.061725886884141934 3.6634305442564844e-11 10.436112037926556 0.3731799095216125 TVGTPIASVPGSTNTGTVPGSEK(ub)DSDSMETEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEK 33 1 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 719830000.0 229010000.0 383761000.0 107059000.0 True False 296457959.4619837 362404362.9969687 87575360.5181046 1.0 1.2224477415100121 0.2954056645233532 28.143252290595306 -6.843367694578532 1.2667444333356401 1.1183327428690875 0.26284059397923715 0.9300761135062944 0.10449192274412453 0.16490463623461357 0.5125635969858262 0.06464447803466808 0.1490836149083935 1.434274593360026e-07 6.843367694578532 -0.8554921488898504 down TVGTPIASVPGSTNTGTVPGSEK(ub)DSDSMETEEKTSSAFVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGK 41 2 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 10845400.0 2533800.0 2376200.0 5935400.0 True False 2453365.9059319994 3325029.0517193 4380740.681816757 1.0 1.355292760725053 1.785604288061782 21.226330989239088 -6.96856773534813 0.2903641265955063 0.9162853763173758 2.2379133018331228 0.9999689559665811 0.0017896745517786787 0.07677023360349639 0.010685077445136665 0.007503081619953952 0.039006167397254876 1.0750589142446318e-07 6.96856773534813 1.321627925515747 TVGTPIASVPGSTNTGTVPGSEK(ub)DSDSMETEEKTSSAFVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGK 41 2 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 120303700.0 44360700.0 47577000.0 28366000.0 True False 67298425.10157956 39086512.62920235 22759447.66674053 1.0 0.5807938680616309 0.33818692833283465 26.004069407907064 -9.075574974575575 0.16815984965580988 1.4741204752519368 9.435354458631246e-20 0.9997575644299442 0.0042564860883506795 0.5308492674003131 0.05634727754738378 0.2895186662125831 0.15988594770979758 8.402819322206479e-10 9.075574974575575 -1.4741204752519368 TVGTPIASVPGSTNTGTVPGSEK(ub)DSDSMETEEKTSSAFVGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGK 41 2 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 79667700.0 44360700.0 15278000.0 20029000.0 True False 57425800.63012634 14427765.869558629 16383927.514894752 1.0 0.2512418757987613 0.2853060355296035 25.775195729999513 -9.965989249333328 5.2970031874684125 1.000002273188603 0.26827395569526885 0.9983772398077123 0.013906634988052528 38207115.14156965 12.910006373619861 1136.4950230879383 0.004760611049400961 1.0814607217965805e-10 9.965989249333328 -0.731728317493334 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEK(ub)TSSAFVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGK 41 2 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 60229000.0 16621000.0 20079000.0 23529000.0 True False 21790291.957992963 17083291.467328988 21094444.78610514 1.0 0.7839863504473429 0.968066184095685 24.377182190795086 -10.132462467508056 6.240512689211543 1.000000478025121 0.8760262673277398 0.37685526807658953 0.07515027739581046 4.997905754767601e-07 6.949913722745918e-08 0.07276422402693711 0.024254647734736443 7.371188756932991e-11 10.132462467508056 -0.12397421069738124 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEK(ub)TSSAFVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGK 41 2 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 87935000.0 24837000.0 27197000.0 35901000.0 True False 24048563.030086428 38056903.930481315 26497451.093086123 1.0 1.5825022011863858 1.1018309518093021 24.519447355657828 -10.14656135179718 3.926958070556677 0.9998557236096273 1.342166576419717 0.40321434915119514 0.19623321640839014 138309785.20454296 212437198.34065402 253738.81946811435 0.07181395919400664 7.135733931058872e-11 10.14656135179718 0.34231085281008977 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEK(ub)TSSAFVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGK 41 2 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 454813000.0 101150000.0 254840000.0 98823000.0 True False 153451945.0555284 209361810.92599216 79290590.73434044 1.0 1.3643477171321101 0.5167128426143325 27.193211691668893 -6.789905240091534 1.49682011702902 1.2036577308774077 0.5077346188308005 0.8009894206609973 0.15487873349875714 0.2354901401113548 1.0423290388556836 0.08144681808713039 0.19069120298211914 1.6221640031767812e-07 6.789905240091534 -0.6959231120466072 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEK(ub)TSSAFVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGK 41 2 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 80677000.0 16621000.0 27572000.0 36484000.0 True False 22766232.865636013 26353777.871588804 27867230.611566063 1.0 1.1575818461985394 1.2240598071730013 24.440392252317977 -13.999999999997845 0.11812678734161776 0.2477787258544726 1.332890970005646 0.9997021776845064 0.0016214849308485815 11.971555519576851 0.10553108823170386 2.11948408183643 0.09657061145495405 1.0000000000049615e-14 13.999999999997845 1.0851122441511734 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEK(ub)TSSAFVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGK 41 2 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 90363000.0 24837000.0 47058000.0 18468000.0 True False 20653065.965660825 46804489.21371833 22329573.413615834 1.0 2.2662247480126494 1.0811747491022632 24.299852631092104 -6.6305813813588665 2.079147897970571 1.8338734588455872 1.086020677395234 0.11941873534503455 0.5430673254340801 0.5573952653440477 4.592891751042432 0.21361845720574302 0.601294232758414 2.3410927425389546e-07 6.6305813813588665 -0.7478527814503533 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEK(ub)TSSAFVGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVGTPIASVPGSTNTGTVPGSEKDSDSMETEEKTSSAFVGK 41 2 Q99460;A0A087WW66;Q99460-2;H7BZR6 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 418651000.0 101150000.0 253300000.0 64201000.0 True False 130940668.96458542 239203632.33140498 52517076.75788902 1.0 1.8268093039611755 0.4010753662186721 26.964338013761342 -6.749485332205027 1.6519134613510407 1.4864652342999114 0.39837135142436403 0.6467357553842837 0.34741941494984113 0.3009174606366111 1.6154812988449712 0.16615665350510742 0.40357571147684246 1.7803880383898415e-07 6.749485332205027 -1.0880938828755473 TVGVEPAADGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVGVEPAADGK 11 0 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 19585000.0 2406000.0 11333000.0 5846000.0 False True 3154289.2997371457 9642160.575688006 5241111.998791728 1.0 3.0568409107216357 1.6615825311991776 21.588883554169037 -10.507618084843266 6.206210026059148 0.9988047509185691 2.359211720960315 0.5585631403602469 0.5696118481954234 0.009425905469936501 0.0007478241521790053 0.551847306857698 0.1838414334886085 3.107290914226413e-11 10.507618084843266 1.360406970041746 TVGVEPAADGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVGVEPAADGK 11 0 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 15247900.0 4737600.0 3816300.0 6694000.0 False True 4587207.481231124 5340168.4917415865 4940640.584304579 1.0 1.1641436568089092 1.0770475511560247 22.12918473189418 -10.430724715555339 4.92353880378305 0.9998101185569144 1.1205956039824823 0.7188053305800621 0.03555683623890321 7.422768914446943e-05 8.582466483118472e-06 0.03448180909752258 0.01147591954975045 3.709157581194439e-11 10.430724715555339 0.12078548542556788 TVGVEPAADGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVGVEPAADGK 11 0 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 39903200.0 6231500.0 30149000.0 3522700.0 False True 9453641.083672993 24768675.39478783 2826436.800945741 1.0 2.620014360135252 0.2989786449400081 23.172438661793695 -6.719034990534314 1.7626951497617473 1.9866054060156582 0.3027704058538277 0.5079977669572238 0.6817898375097112 0.3571979439200703 2.168463187123745 0.3071716578296494 0.7720193096477919 1.9096993904035925e-07 6.719034990534314 -1.6838350001618305 TVGVEPAADGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVGVEPAADGK 11 0 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 14037800.0 2406000.0 5820900.0 5810900.0 False True 3295563.2197052096 5563713.390857798 4438485.099242112 1.0 1.6882435626149135 1.346806237156372 21.65209361569193 -10.028324001461213 4.356483148373262 0.9999705364538183 1.5175248996264254 0.7538902219122617 0.13939120472773678 97101339.64083377 209855576.7203512 43487.081953618224 0.051011939575254406 9.368628081377852e-11 10.028324001461213 0.5175543631726072 TVGVEPAADGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVGVEPAADGK 11 0 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 8359900.0 4737600.0 2540400.0 1081900.0 False True 3939524.3112660423 2526714.3609700804 1308120.2878595951 1.0 0.6413754964639555 0.332050314835906 21.909590007328458 -7.54079405408189 0.24536933123343446 1.1411684063716505 9.55934640436325e-16 0.9998623863226141 0.003201784970022101 0.1284467524080651 0.02559920887120111 0.02974931535391487 0.06837200668002752 2.8787632236620905e-08 7.54079405408189 -1.1411684063716496 down TVGVEPAADGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVGVEPAADGK 11 0 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 13787600.0 6231500.0 3898000.0 3658100.0 False True 8066799.591228991 3681072.873382612 2992363.3352756733 1.0 0.45632382852116876 0.3709480198974153 22.943564983886144 -13.999999999999998 0.2605890303721516 4.992219625571368 0.33991931943685205 0.9995635383180503 0.005820488272042981 14.443208537601995 0.1615421799672374 30.3746296283599 0.037209629350923264 1.0000000000000041e-14 13.999999999999998 -4.652300306134515 TVHNLYLFDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVHNLYLFDR 10 0 I3L3S0;Q9Y5R8;I3L3V5;I3L1R8 I3L3S0 TRAPPC1 Trafficking protein particle complex subunit 1 0 5185100.0 1292200.0 1989100.0 1903800.0 False True 1694086.7136826026 1692334.0334510705 1706813.0385391228 1.0 0.9989654129169563 1.007512203923054 20.692076291808977 -6.876647808385836 1.0983939068200987 0.9993833354899158 1.0080801196371274 0.9708739194066928 0.000649970421480213 0.13063722674945738 0.29062111224557985 0.0004571471595739658 0.001096609442960164 1.3284713463989195e-07 6.876647808385836 0.008696784147211645 TVHNLYLFDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVHNLYLFDR 10 0 I3L3S0;Q9Y5R8;I3L3V5;I3L1R8 I3L3S0 TRAPPC1 Trafficking protein particle complex subunit 1 0 3333150.0 1769000.0 395550.0 1168600.0 False True 1712844.0633016448 553495.1777660004 862508.6027514682 1.0 0.32314393915059253 0.5035534881610375 20.70796238429445 -10.813430331924584 10.776196537946367 1.0057262277341672 0.4133487136576412 0.9337692288918903 0.07365188996687068 0.01002900950555479 0.00017363317316655016 0.07058418140149911 0.023771045271532603 1.5366312748362603e-11 10.813430331924584 -0.592377514076526 TVHNLYLFDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVHNLYLFDR 10 0 I3L3S0;Q9Y5R8;I3L3V5;I3L1R8 I3L3S0 TRAPPC1 Trafficking protein particle complex subunit 1 0 4144600.0 1292200.0 938800.0 1913600.0 False True 1769961.2603919674 897320.7118035526 1461647.091829099 1.0 0.506971950111968 0.825807391685742 20.75528635333187 -10.124961414966815 5.2717211263481 1.0000081335491149 0.6663896708986125 0.59345797833864 0.1301640239626391 1.244334059672528e-05 2.0652315927953753e-06 0.12603384547797006 0.042010258090097084 7.499608368848467e-11 10.124961414966815 -0.33361846265050243 TVHSLACLLTQYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVHSLACLLTQYR 13 0 F8VPD4;P27708;H7C2E4 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 6510300.0 3793900.0 2716400.0 0.0 False True 4973839.640179862 2311123.7084442684 0.0 1.0 0.46465585455841 0.0 22.245928564203748 -8.042963806469185 0.5719520173356774 1.0167366522429815 3.7966690005696274e-19 0.989924683915785 0.04101239131542749 0.1127508363455236 0.16657609845069168 0.047400037446191194 0.07561389695083101 9.058080866070795e-09 8.042963806469185 -1.0167366522429815 TVHSLACLLTQYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVHSLACLLTQYR 13 0 F8VPD4;P27708;H7C2E4 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 10403500.0 3793900.0 2425900.0 4183700.0 False True 5196607.356292429 2318715.7166214758 3195596.2260061684 1.0 0.4461979821919404 0.6149389412953643 22.30913862572664 -10.924710722379995 11.58463772597981 1.0630047449690823 0.5305684617436526 0.9116538300994933 0.06888820808520543 0.033269435574324234 0.00021621976034741296 0.019795811494465448 0.022233573555339305 1.1892941362410348e-11 10.924710722379995 -0.5324362832254297 TVHTEWTQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVHTEWTQR 9 0 C9JIF9;P13798;H7C393 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 6952080.0 2287580.0 1639100.0 3025400.0 False True 2999039.5329562346 1394552.6691617595 2712360.6296860245 1.0 0.4649997620361847 0.9044097618187704 21.51606910907801 -10.040421076412645 7.22210915168013 1.0000000370282927 0.6847047619274799 0.40705222389104323 0.17938838122396725 1.0697845787742564e-07 1.397657388294781e-08 0.17369207395152428 0.05789735108196103 9.11127014763127e-11 10.040421076412645 -0.3152952751008128 TVHTEWTQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVHTEWTQR 9 0 C9JIF9;P13798;H7C393 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 8718680.0 3065100.0 1980580.0 3673000.0 False True 2967800.0782509125 2771435.922588253 2710931.112361922 1.0 0.9338351133886391 0.9134480224017052 21.50096247939931 -13.999966889080103 0.16487406052733125 1.3294290879703294 0.894446527215653 0.9995243807123357 0.0008057106171405159 12.045584016769281 0.1284643066875903 1.268773626557977 0.017430301785881896 1.000076243616968e-14 13.999966889080103 -0.43498256075467645 TVHTEWTQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVHTEWTQR 9 0 C9JIF9;P13798;H7C393 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 21407900.0 6467700.0 11839600.0 3100600.0 False True 9811973.75220603 9726730.876782993 2487765.0509587433 1.0 0.991312362061316 0.2535437939180604 23.226111943903256 -6.909471161294804 0.8993267019911397 1.0232266548756996 0.1592696798184768 0.9907204953612246 0.03370141473331839 0.10476886278260146 0.14067118539794454 0.02751984454762409 0.07569192659683728 1.2317677768018138e-07 6.909471161294804 -0.8639569750572228 down TVHTEWTQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVHTEWTQR 9 0 C9JIF9;P13798;H7C393 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 7584080.0 2287580.0 2476600.0 2819900.0 False True 3133360.145525039 2367175.6229789928 2153897.697663503 1.0 0.7554751171389329 0.6874082766194712 21.579279170600902 -13.999999999997689 0.17941383660051194 2.2664615444816008 0.6330107880409058 0.9994988550465342 0.0030047164997445844 12.197184777886894 0.13426984131435307 5.3842091879901695 0.05107535874087158 1.0000000000053213e-14 13.999999999997689 -1.6334507564406948 TVHTEWTQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVHTEWTQR 9 0 C9JIF9;P13798;H7C393 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 8112450.0 3065100.0 3086400.0 1960950.0 False True 2548766.456953215 3069772.9505975633 2370975.5785916154 1.0 1.2044151562898224 0.9302443431501645 21.281367754833585 -6.707165431773096 1.8060471763309507 1.1260379270643774 0.9309611847121625 0.45131486645677765 0.08617900934854876 0.3807898212875751 2.419546366571612 0.03800466106608305 0.09685634003269744 1.9626125346213319e-07 6.707165431773096 -0.19507674235221495 TVHTEWTQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVHTEWTQR 9 0 C9JIF9;P13798;H7C393 C9JIF9 APEH Acylamino-acid-releasing enzyme 0 17798600.0 6467700.0 5112500.0 6218400.0 False True 8372565.14742707 4827984.8807513155 5086715.006172133 1.0 0.5766434534385174 0.6075455868785093 22.997238265995705 -9.97808480805247 5.28767716795167 1.0000016106526322 0.5920945201568613 0.9957139837942383 0.012615743154343995 2.3954613056906547e-07 4.6282614808880275e-08 0.012215188921181284 0.004071713593899712 1.0517564691237868e-10 9.97808480805247 -0.4079070904957709 TVHYLPILFIDQLSNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVHYLPILFIDQLSNR 16 0 Q96KA5;Q96KA5-2;G5E9Z2 Q96KA5 CLPTM1L Cleft lip and palate transmembrane protein 1-like protein 0 2215170.0 1247500.0 967670.0 0.0 False True 1635484.5808071857 823297.4079481176 0.0 1.0 0.5033966187206627 0.0 20.641286727217583 -7.918214037954564 0.5950335926885136 1.0100372145771699 2.499235139460038e-18 0.9889177996056145 0.0429774566307216 0.11269159149350479 0.16111304121243522 0.04470506284694616 0.07709966814050062 1.2072187220673345e-08 7.918214037954564 -1.0100372145771699 down TVIDYNGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVIDYNGER 9 0 P07237;H7BZ94;H0Y3Z3;I3L0S0 P07237 P4HB Protein disulfide-isomerase 0 31626500.0 5499500.0 14455000.0 11672000.0 False True 7209897.7572337575 12298370.345148701 10464293.405729907 1.0 1.7057621008300197 1.4513788902527756 22.781547370235806 -10.400713903658632 5.537503951747694 0.9997221520761944 1.578570495541401 0.8733732466336085 0.10385151084088076 0.00035640076499917337 3.8570882874363344e-05 0.10060080697869929 0.03351793099709909 3.974532900423959e-11 10.400713903658632 0.5788483434652066 TVIDYNGER ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVIDYNGER 9 0 P07237;H7BZ94;H0Y3Z3;I3L0S0 P07237 P4HB Protein disulfide-isomerase 0 29538000.0 9297600.0 6091400.0 14149000.0 False True 9002452.77724893 8523727.786231363 10442952.439098503 1.0 0.9468228267492383 1.1600119098086263 23.10188669604104 -6.840653562965838 1.2792368891808545 0.9717112157407898 1.167119969619 0.9255828720470514 0.02471622733734828 0.1680439423630654 0.5338790753088791 0.015147896274722746 0.034906490610506664 1.443266186973245e-07 6.840653562965838 0.19540875387821022 TVIDYNGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVIDYNGER 9 0 P07237;H7BZ94;H0Y3Z3;I3L0S0 P07237 P4HB Protein disulfide-isomerase 0 113348000.0 20067000.0 79857000.0 13424000.0 False True 30443106.09420943 65605894.42441121 10770740.516051777 1.0 2.155032874155048 0.3537990007563806 24.859612227984012 -6.733541359070036 1.7104559918430258 1.6923518791569765 0.3541895272495041 0.5755169025572384 0.4854286251924349 0.32965250350250463 1.8910226372378525 0.22476265824493902 0.5554817425498756 1.8469648949359728e-07 6.733541359070036 -1.3381623519074723 TVIDYNGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVIDYNGER 9 0 P07237;H7BZ94;H0Y3Z3;I3L0S0 P07237 P4HB Protein disulfide-isomerase 0 32775500.0 5499500.0 11277000.0 15999000.0 False True 7532813.768399329 10778744.851947885 12220365.70974798 1.0 1.4309055265862884 1.6222843263447255 22.844757431758698 -11.376015927360594 0.14588563137600305 2.3560288319370377e-19 1.8826691598414258 0.9996495220147372 0.0048720423848836875 3.991854390415717 0.09117605873135194 1.4773510626711737 0.1901991332571458 4.207111988956413e-12 11.376015927360594 1.8826691598414258 TVIDYNGER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVIDYNGER 9 0 P07237;H7BZ94;H0Y3Z3;I3L0S0 P07237 P4HB Protein disulfide-isomerase 0 19964900.0 9297600.0 7112300.0 3555000.0 False True 7731366.353518065 7073984.62821898 4298334.063537159 1.0 0.9149721155045315 0.5559604689514233 22.882291971475315 -6.943633769111482 0.6248427911293327 1.0039194654327461 0.4478346395301761 0.9986021756078952 0.00719475799686418 0.08614727171147195 0.04734912976762803 0.007213989210470948 0.030439695635933676 1.1385870262476163e-07 6.943633769111482 -0.55608482590257 TVIDYNGER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVIDYNGER 9 0 P07237;H7BZ94;H0Y3Z3;I3L0S0 P07237 P4HB Protein disulfide-isomerase 0 52029000.0 20067000.0 15408000.0 16554000.0 False True 25977127.07970669 14550531.255279467 13541341.858383732 1.0 0.5601285781385089 0.5212794246582493 24.63073855007646 -13.999999999999998 0.3435532655518108 6.199275096509307 0.5154449554924365 0.9997422360284719 0.0034854510076925507 20.034318323291874 0.1882408842377414 75.78047351695096 0.0118527206613485 1.0000000000000041e-14 13.999999999999998 -5.683830141016871 TVIFVATGEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVIFVATGEGK 11 0 O95336;M0R261 O95336 PGLS 6-phosphogluconolactonase 0 6502900.0 1958300.0 2008400.0 2536200.0 False True 2567350.2642041733 1708754.5486818843 2273778.3529482735 1.0 0.6655712594056828 0.8856517884025843 21.291848705891198 -10.467823349826274 4.984775905330496 1.000499136358161 0.7756115239041204 0.5808960058149519 0.08984749972741352 0.0004994859264855146 5.332516671154756e-05 0.08718510967717187 0.028998155845214084 3.405466795958935e-11 10.467823349826274 -0.22488761245404065 TVIFVATGEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVIFVATGEGK 11 0 O95336;M0R261 O95336 PGLS 6-phosphogluconolactonase 0 4430300.0 2413800.0 0.0 2016500.0 False True 2337175.240247317 0.0 1488318.15629671 1.0 0.0 0.636802123635033 21.156334480063414 -10.24357635777364 7.271651442731324 1.0000021531775145 0.3184010618175166 0.6043556072168763 0.2599733783377598 9.074670728473796e-06 9.439639485397461e-07 0.25171893604934265 0.08390604706328525 5.707207230776947e-11 10.24357635777364 -0.6816010913599979 TVIFVATGEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVIFVATGEGK 11 0 O95336;M0R261 O95336 PGLS 6-phosphogluconolactonase 0 5801100.0 1958300.0 1299400.0 2543400.0 False True 2682336.4310676227 1241988.2114588162 1942701.3029672492 1.0 0.4630247708951559 0.7242571366016215 21.35505876741409 -10.129039659453523 5.161031632872878 1.0000129973815406 0.5936409537479029 0.7633863658519539 0.10664766671520058 1.5949989534388053e-05 2.6914839737880674e-06 0.10326445888322343 0.03442038642474241 7.4295128903205e-11 10.129039659453523 -0.40637204363363766 TVIGCSGFHGDCLTLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVIGCSGFHGDCLTLTK 17 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 28321100.0 7419600.0 9465500.0 11436000.0 False True 9727167.451508608 8053284.296230027 10252712.42185806 1.0 0.8279166917169731 1.0540285723433231 23.213588323087166 -6.703224743434256 1.819131459832369 0.8934852775980566 1.0534039758595592 0.4330286857321618 0.07259620096372171 0.38883882202140146 2.5037640158554098 0.03180877663816471 0.08148694990503261 1.9805018689154145e-07 6.703224743434256 0.15991869826150262 TVIGCSGFHGDCLTLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVIGCSGFHGDCLTLTK 17 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 56726500.0 11288000.0 37530000.0 7908500.0 False True 17124721.263339628 30832478.276771627 6345381.508581317 1.0 1.800465993147426 0.3705392578952759 24.029577169933148 -6.754756435042848 1.6319429686525215 1.467955471474171 0.36656939276541595 0.6693580039165116 0.33647275845858654 0.29178849831825804 1.5302393658994269 0.1627695440311378 0.3932540354035739 1.7589097850815e-07 6.754756435042848 -1.101386078708755 TVIGCSGFHGDCLTLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVIGCSGFHGDCLTLTK 17 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 23904900.0 7419600.0 9012600.0 7472700.0 False True 10162826.62715077 8614393.531317312 5707802.1650874335 1.0 0.8476375566914917 0.5616352983763988 23.276798384610057 -6.961266002514457 0.4172114917495157 1.0130277891717603 0.3855055811756009 0.9998143008192456 0.0024762178707324833 0.07925198583161423 0.01948323869083729 0.003693630232975211 0.02382630190018642 1.0932865303470655e-07 6.961266002514457 -0.6275222079961593 TVIGCSGFHGDCLTLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVIGCSGFHGDCLTLTK 17 0 P20618 P20618 PSMB1 Proteasome subunit beta type-1 0 26234300.0 11288000.0 8149300.0 6797000.0 False True 14612538.51974532 7695784.2911895765 5560015.743109475 1.0 0.5266562193003345 0.3804962249096182 23.800703492025598 -13.999999999999998 0.16456741852649986 3.3550587703385344 0.2438164080180642 0.9995251067334061 0.0057619778253418024 12.043277591132945 0.12833714810512714 9.051715886229836 0.12532506225838255 1.0000000000000041e-14 13.999999999999998 -3.1112423623204704 TVIGCSGFHGDCLTLTK(ub)IIEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVIGCSGFHGDCLTLTKIIEAR 22 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 190038000.0 20575000.0 75029000.0 94434000.0 True False 31213779.23398414 61639488.74574742 75769078.50810747 1.0 1.974752505413928 2.4274240533364684 24.895679707532235 -9.699874497313933 0.20248748369627625 1.1328496982855137e-23 2.841489463057423 0.9994332056548813 0.014179576817357037 1.1478829383487608 0.08577665130162142 0.9342672238758458 0.2621349425671153 1.9958389904178845e-10 9.699874497313933 2.841489463057423 TVIGCSGFHGDCLTLTK(ub)IIEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVIGCSGFHGDCLTLTKIIEAR 22 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 19909400.0 3327800.0 9188900.0 7392700.0 True False 4558177.590413546 8782904.01437118 5646696.51743571 1.0 1.9268455079158822 1.238805730016194 22.120025703628528 -10.180496114655076 4.6269369920183285 0.9999128989264756 1.582825618968031 0.4889430101500173 0.28089106314740814 197082766.64118436 34.32489949156303 197651.36443308005 0.09615648217205464 6.599391382752848e-11 10.180496114655076 0.5829127200415554 TVIGCSGFHGDCLTLTK(ub)IIEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVIGCSGFHGDCLTLTKIIEAR 22 1 P20618 P20618 PSMB1 Proteasome subunit beta type-1 1 128387000.0 20575000.0 60459000.0 47353000.0 True False 26634743.09388378 57094403.50226771 38735239.88281048 1.0 2.143606315293444 1.4543125025187638 24.666806029624684 -10.158420067883513 4.752176012025612 0.9999597408974518 1.7989594088834946 0.6417498540386075 0.28140302164668785 0.00023857996943016388 4.224980021456487e-05 0.2724943748510767 0.090822434557293 6.94352385858096e-11 10.158420067883513 0.7989996679860428 TVIGSVLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVIGSVLLR 9 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 9787200.0 2408300.0 3009400.0 4369500.0 False True 3157304.622010378 2560409.250549325 3917386.0552036366 1.0 0.8109478042441826 1.2407374403770026 21.590262030311568 -6.7871244556606385 1.5076712554141818 0.8939430119256233 1.2449617576864827 0.7919190209886589 0.08023073418230207 0.23966207523934818 1.0762213366791864 0.04189257831327692 0.09829566747397724 1.6325840316561667e-07 6.7871244556606385 0.35101874576085934 TVIGSVLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVIGSVLLR 9 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 7058200.0 2193400.0 1150400.0 3714400.0 False True 2123771.717606458 1609760.7192567473 2741487.2103885445 1.0 0.7579725758241976 1.2908577638835246 21.01819726975212 -6.783199096510909 1.5231570988748437 0.8635279251507413 1.2955293569125197 0.7786277250371898 0.10250063753718847 0.24563455023785988 1.1257380636805936 0.05298952648177739 0.12471602467901878 1.6474069866326303e-07 6.783199096510909 0.4320014317617784 TVIGSVLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVIGSVLLR 9 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 8230400.0 2408300.0 2640700.0 3181400.0 False True 3298713.591860373 2524025.142372862 2430018.8429897055 1.0 0.7651543767245914 0.736656510278981 21.65347209183446 -13.999999999999961 0.2975086177590264 3.1118020888343243 0.7294619755151096 0.9996442649423881 0.002225569125850606 16.42814017041325 0.1731566814034093 21.3257585687443 0.010410646565677478 1.00000000000009e-14 13.999999999999961 -2.3823401133192146 TVIGSVLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVIGSVLLR 9 0 O00203;O00203-3 O00203 AP3B1 AP-3 complex subunit beta-1 0 6047000.0 2193400.0 1577300.0 2276300.0 False True 1823909.2840955218 1568802.7718304626 2752263.8055779575 1.0 0.8601320172611727 1.5089916091648208 20.798602545186398 -6.850285660425712 1.2336272408014977 0.9253388169167182 1.5350853205302104 0.9407278066004084 0.06788064980559642 0.15714658710600274 0.4600508812625708 0.04305260057437239 0.09964971851570639 1.4116087430430227e-07 6.850285660425712 0.6097465036134923 TVIIDHGSGFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVIIDHGSGFLK 12 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 44479100.0 7560100.0 17673000.0 19246000.0 False True 9911364.312112534 15036257.288814446 17254608.5406681 1.0 1.5170724044962058 1.7408913644291628 23.24065222924292 -10.989160083214173 0.16125450650939518 2.902916308127073e-17 2.0059136538736158 0.9995851369609507 0.006319530987544023 3.1642980983737754 0.09284761701998122 1.3656914856709657 0.18963442785487575 1.0252739352638334e-11 10.989160083214173 2.0059136538736158 TVIIDHGSGFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVIIDHGSGFLK 12 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 29330000.0 9771100.0 8158900.0 11400000.0 False True 9460921.778929735 11416791.318101417 8413998.007330758 1.0 1.2067313930792207 0.8893423076459037 23.17354932171602 -6.73093327470724 1.7197580121190974 1.1242833810669075 0.8894977247707684 0.5635512108565242 0.08689923448453893 0.33452537914328534 1.938699914664248 0.04003523642673882 0.0992425553603784 1.8580899113308488e-07 6.73093327470724 -0.23478565629613912 TVIIDHGSGFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVIIDHGSGFLK 12 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 91071000.0 16821000.0 74250000.0 0.0 False True 25518686.77982245 60999507.382102154 0.0 1.0 2.3903858340521773 0.0 24.605050752523354 -6.750973448582027 1.6588602799822216 1.8184582698785923 1.7050099907668256e-09 0.6446564123657581 0.5843037308982857 0.30023093184461075 1.6279974438698777 0.2788328402684872 0.6729114052550381 1.7742979526494412e-07 6.750973448582027 -1.8184582681735824 TVIIDHGSGFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVIIDHGSGFLK 12 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 39249100.0 7560100.0 14459000.0 17230000.0 False True 10355273.274020495 13820153.570481008 13160628.862988811 1.0 1.3346005657961022 1.270910821446542 23.30386229076581 -10.082935817385646 4.404250438401124 0.9999732071367274 1.3027556936446316 0.9678755873129842 0.026001229338641456 18068523.726763673 0.48060187099377566 5071.313368043515 0.008900912381687885 8.261600353856919e-11 10.082935817385646 0.3027824865079042 TVIIDHGSGFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVIIDHGSGFLK 12 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 23165500.0 9771100.0 8346700.0 5047700.0 False True 8125102.583124723 8301734.6704097595 6103150.732072171 1.0 1.0217390593506954 0.7511475294783346 22.953954597150297 -6.887446299065896 1.0373477456612321 1.0154416531437997 0.7290041031187975 0.9792136738667154 0.017698209218742985 0.12124052949891201 0.2341349644414078 0.013040926549189256 0.03222694988072535 1.295846920340083e-07 6.887446299065896 -0.28643755002500226 TVIIDHGSGFLK(ub)AGTAGWNEPQMVFPNIVNYLPCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVIIDHGSGFLKAGTAGWNEPQMVFPNIVNYLPCK 35 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 87777600.0 7813600.0 14913000.0 65051000.0 True False 11853802.45067597 12251658.63419918 52193641.33713385 1.0 1.0335635915292751 4.403113815529925 23.4988465838227 -6.909078958432288 0.9019837484147963 0.8926090010358552 4.830101180013008 0.9905693550236196 0.15502794003500847 0.10503019426996779 0.14209407931624504 0.12634830905133124 0.346592621976076 1.2328806646560447e-07 6.909078958432288 3.937492178977153 up TVIIEQSWGSPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVIIEQSWGSPK 12 0 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25;C9JCQ4;C9JL19 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 472910000.0 105270000.0 179970000.0 187670000.0 False True 138009989.43612996 153119177.5175654 168251708.65775654 1.0 1.1094789452790146 1.219127030914108 27.040197455003643 -6.971106138874266 0.2302397786701343 0.9555401601311252 1.3761996909547394 0.9999897673725542 0.00028610506472446866 0.07594539419588181 0.007733742593056043 0.0028123926777435058 0.010885168371564724 1.0687936407731857e-07 6.971106138874266 0.4206595308236142 TVIIEQSWGSPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVIIEQSWGSPK 12 0 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25;C9JCQ4;C9JL19 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 306638000.0 90585000.0 58433000.0 157620000.0 False True 87709428.75872213 81765601.62406954 116334593.50135764 1.0 0.9322327460254778 1.3263635979363158 26.386228604855006 -6.862586634174532 1.1725011540767032 0.9629444272819315 1.3464228634628705 0.9567132641279946 0.0357980791596071 0.14416639211735488 0.3751334818406005 0.02378555192663264 0.05569802016511625 1.372187206288732e-07 6.862586634174532 0.383478436180939 TVIIEQSWGSPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVIIEQSWGSPK 12 0 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25;C9JCQ4;C9JL19 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 702720000.0 123940000.0 390790000.0 187990000.0 False True 188026041.22770318 321050471.2437937 150833694.10105607 1.0 1.7074787574503862 0.8021957656301104 27.486357245194856 -6.698204247700665 1.8373097382193928 1.4400832867087134 0.8049792446647512 0.4090756449256828 0.2987340838384131 0.3992519445923631 2.6189729664763437 0.12977711053726645 0.33448982222557433 2.0035295503990212e-07 6.698204247700665 -0.6351040420439622 TVIIEQSWGSPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVIIEQSWGSPK 12 0 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25;C9JCQ4;C9JL19 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 398440000.0 105270000.0 170160000.0 123010000.0 False True 144191163.8147825 162641768.5561275 93957571.47047313 1.0 1.1279593301920032 0.6516180949282315 27.103407516526534 -6.835203553173278 1.304495798265179 1.0681672018641692 0.637382276876671 0.9158856938987388 0.05837790680434101 0.17447696506016946 0.578808609161367 0.035116274852829046 0.08082599700137877 1.4614920147839752e-07 6.835203553173278 -0.4307849249874982 TVIIEQSWGSPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVIIEQSWGSPK 12 0 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25;C9JCQ4;C9JL19 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 229362900.0 90585000.0 80556900.0 58221000.0 False True 75325441.09592092 80122923.99040721 70394741.91651122 1.0 1.0636900736947172 0.9345413832607917 26.166633880289282 -6.772625771059541 1.5645686355311885 1.036408282060329 0.9337445765098248 0.7404520877443714 0.02686189931597608 0.26220048051678235 1.2670567255092327 0.01353051178717694 0.03212909205491266 1.6880069443037332e-07 6.772625771059541 -0.1026637055505043 TVIIEQSWGSPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVIIEQSWGSPK 12 0 P10809;E7ESH4;E7EXB4;P10809-2;C9JL25;C9JCQ4;C9JL19 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 484230000.0 123940000.0 195930000.0 164360000.0 False True 160442773.22264662 185026323.26368812 134448166.4760149 1.0 1.1532231682814835 0.8379820653526167 27.257483567287306 -6.774539069006351 1.5570839034035362 1.0873742190539093 0.8358967092862506 0.7476148871072389 0.06466293438585678 0.2591529553400644 1.2405773815060033 0.03272188081282249 0.0775717754909085 1.680586733810321e-07 6.774539069006351 -0.2514775097676587 TVIK(ub)EGEEQLQTQHQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVIKEGEEQLQTQHQK 16 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 4616300.0 624920.0 2467280.0 1524100.0 True False 819276.1717338894 2099171.441382112 1366400.7521995348 1.0 2.562226894673983 1.6678145896855865 19.64399032975761 -10.390823464456059 7.292876482828966 0.9999597622506393 2.1150207421797846 0.6744990583743955 0.36514229448135604 0.000238897685610639 1.9955163476053093e-05 0.3535600987965327 0.11784916879352134 4.0660857713005566e-11 10.390823464456059 1.1150609799291453 TVIK(ub)EGEEQLQTQHQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVIKEGEEQLQTQHQK 16 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 7685840.0 863740.0 1116700.0 5705400.0 True False 836321.0464873733 1562604.1335135694 4210984.581668858 1.0 1.8684261744657187 5.035129271653975 19.6736973440907 -6.947002465527105 0.5908368162733241 0.9634877290886691 6.099641033263835 0.9989445631687233 0.0563370879437288 0.08471220894928025 0.04111933460242398 0.05835645752969208 0.26535759730969644 1.1297895007424805e-07 6.947002465527105 5.136153304175166 TVIK(ub)EGEEQLQTQHQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVIKEGEEQLQTQHQK 16 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 52219500.0 6201300.0 13596200.0 32422000.0 True False 9407825.47575727 11169851.882404547 26013777.48893257 1.0 1.1872936962093725 2.765121180868699 23.165429866361237 -6.929147058552713 0.7537614377479906 0.9752316541668707 3.0821149343883496 0.9963679488393594 0.04770948375478985 0.09308302881319885 0.07986780027555457 0.04324721562818291 0.14344148342987822 1.1772072861773085e-07 6.929147058552713 2.1068832802214787 up TVIK(ub)EGEEQLQTQHQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVIKEGEEQLQTQHQK 16 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 5481360.0 624920.0 871540.0 3984900.0 True False 855969.811828005 833032.4810026296 3043748.6915916465 1.0 0.9732031077399909 3.5559065863449453 19.7072003912805 -6.904554781322641 0.932008602693663 0.9056230031446582 3.8535583865602536 0.988699675632699 0.12875751309918193 0.10813029116664533 0.15910889129960534 0.10265602581453821 0.2737501580932892 1.2457910849452453e-07 6.904554781322641 2.9479353834155955 up TVIK(ub)EGEEQLQTQHQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVIKEGEEQLQTQHQK 16 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 7645040.0 863740.0 3396500.0 3384800.0 True False 718238.0801699044 3378202.380347539 4092546.0304530463 1.0 4.703457632806661 5.698035433438624 19.454102619524978 -9.386486557047657 0.4160031179408976 2.2322761299450566e-21 5.811747447056809 0.9981005990615707 0.08809904598404351 0.7436997350289746 0.16872212282236704 1.4174955525602695 0.24041420403572145 4.106893519680482e-10 9.386486557047657 5.811747447056809 TVIK(ub)EGEEQLQTQHQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVIKEGEEQLQTQHQK 16 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 48875100.0 6201300.0 8941800.0 33732000.0 True False 8027705.095898005 8444180.969526084 27593122.11954813 1.0 1.0518798172893633 3.4372366435891695 22.936556188453686 -6.911593072679638 0.8848096988573311 0.929813383380809 3.756250762597362 0.9915091184483256 0.10476016366628801 0.10337418291961589 0.13312046540755337 0.08644985654385373 0.24136081237986526 1.2257641837453076e-07 6.911593072679638 2.8264373792165527 up TVINFTMPNTIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVINFTMPNTIK 12 0 Q96GQ7;B7Z6D5 Q96GQ7 DDX27 Probable ATP-dependent RNA helicase DDX27 0 15089100.0 4074900.0 4519000.0 6495200.0 False True 5342233.361387727 3844782.814924031 5823139.010357856 1.0 0.7196957816768397 1.0900195885200354 22.349011567005068 -6.704260784625107 1.8155050202178578 0.8266764461208758 1.089017008418252 0.4379032028287463 0.11822998562666151 0.38672150675888334 2.480915001464895 0.05189428789664453 0.1327693748164449 1.9757828681253632e-07 6.704260784625107 0.26234056229737623 TVINFTMPNTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVINFTMPNTIK 12 0 Q96GQ7;B7Z6D5 Q96GQ7 DDX27 Probable ATP-dependent RNA helicase DDX27 0 12373300.0 3890800.0 2374500.0 6108000.0 False True 3767288.6837162445 3322650.2328539197 4508131.563927748 1.0 0.8819738840869209 1.196651476010779 21.845095159181838 -6.805085152345035 1.4348419062226343 0.9352940459383111 1.201572311266649 0.8466830869987669 0.050822694293321244 0.21357022676444226 0.8674176158022064 0.027857289420662495 0.06460222754454772 1.5664439065244798e-07 6.805085152345035 0.26627826532833787 TVINFTMPNTIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVINFTMPNTIK 12 0 Q96GQ7;B7Z6D5 Q96GQ7 DDX27 Probable ATP-dependent RNA helicase DDX27 0 13280700.0 3684200.0 4459000.0 5137500.0 False True 5589200.751098137 3663256.611673988 4122070.8731537606 1.0 0.6554168967636831 0.737506319189533 22.41421056350763 -10.806455787445215 7.5008654318303964 1.0107266605072822 0.696461607976608 0.9479984776380239 0.03351286637051914 0.0060177506222784585 0.0001552753158393896 0.0324819452238682 0.01081623111139127 1.56150799634162e-11 10.806455787445215 -0.31426505253067416 TVINFTMPNTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVINFTMPNTIK 12 0 Q96GQ7;B7Z6D5 Q96GQ7 DDX27 Probable ATP-dependent RNA helicase DDX27 0 16670200.0 4074900.0 5579800.0 7015500.0 False True 5581500.650031893 5333265.986068883 5358583.388757862 1.0 0.9555254617839037 0.9600614108550257 22.41222162852796 -10.40938712968257 5.822788867302862 1.0000153590742666 0.9577934366109996 0.9914119221605721 0.0018517934539168928 3.6935972628532583e-07 3.7464521611269626e-08 0.0017936437102699272 0.0005976637673029874 3.8959454764188594e-11 10.40938712968257 -0.04222192246326706 TVINFTMPNTIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVINFTMPNTIK 12 0 Q96GQ7;B7Z6D5 Q96GQ7 DDX27 Probable ATP-dependent RNA helicase DDX27 0 8557700.0 3890800.0 2421200.0 2245700.0 False True 3235372.591665387 2408156.5150294267 2715265.487056376 1.0 0.7443212325013372 0.8392435214575118 21.625500434616114 -10.350007967701007 4.922199541230087 1.0001315609500878 0.7917823769793578 0.8651491483800612 0.038751862193505536 5.5982699000737114e-05 7.392706553486359e-06 0.03754495240070868 0.012507109742464767 4.466753972306777e-11 10.350007967701007 -0.20834918397073 TVIPGMPTVIPPGLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVIPGMPTVIPPGLTR 16 0 Q15637-6;Q15637-2;Q15637-4;Q15637-3;Q15637;Q15637-5;Q15637-7;F8WEV5;C9J792 Q15637-6 SF1 Splicing factor 1 0 9275700.0 0.0 5464400.0 3811300.0 False True 0.0 4649132.8200643705 3416943.236571149 0.0 TVIPGMPTVIPPGLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVIPGMPTVIPPGLTR 16 0 Q15637-6;Q15637-2;Q15637-4;Q15637-3;Q15637;Q15637-5;Q15637-7;F8WEV5;C9J792 Q15637-6 SF1 Splicing factor 1 0 10612600.0 0.0 5341000.0 5271600.0 False True 0.0 5105016.959674878 4026556.652009971 0.0 TVIQPGIYHPDIQLLHPINLEFLVNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVIQPGIYHPDIQLLHPINLEFLVNR 26 0 Q709C8-3;Q709C8;Q709C8-4;Q709C8-2 Q709C8-3 VPS13C Vacuolar protein sorting-associated protein 13C 0 30467900.0 9764800.0 6845100.0 13858000.0 False True 14813915.502503417 5623538.423989596 11118960.225822834 1.0 0.37961188742026164 0.7505753778563021 23.82044967752191 -10.493294978696692 5.921017639449023 1.000434696753775 0.5650936326383703 0.6469675805704413 0.15144521079502143 0.0008698786219307496 7.444148823639494e-05 0.14677757609055372 0.04887873160599911 3.21147851797105e-11 10.493294978696692 -0.43534106411540463 TVIQPGIYHPDIQLLHPINLEFLVNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVIQPGIYHPDIQLLHPINLEFLVNR 26 0 Q709C8-3;Q709C8;Q709C8-4;Q709C8-2 Q709C8-3 VPS13C Vacuolar protein sorting-associated protein 13C 0 20013300.0 9764800.0 5481600.0 4766900.0 False True 12640726.09298449 5176544.141286334 3899373.112524429 1.0 0.4095131959357365 0.30847698809711194 23.59157599961436 -13.999999999999998 0.24837944810459467 5.073257935797294 0.2672210521474119 0.9995396697503893 0.006543327339615847 13.934334241142935 0.15770662739147717 28.291089669645647 0.04705151973125902 1.0000000000000041e-14 13.999999999999998 -4.806036883649882 TVISQSLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVISQSLSK 9 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 3034430.0 531330.0 1475300.0 1027800.0 False True 696578.7754070397 1255190.9906743588 921453.1153537714 1.0 1.8019368878141586 1.3228268616357546 19.40992698944944 -10.138301378784622 4.885275402816953 0.9999652954147623 1.5623818747273333 0.647526380337623 0.19559584913964856 7.393928312711864e-05 1.3041825038638581e-05 0.189396520875437 0.06312828885759164 7.272749367222956e-11 10.138301378784622 0.5624165793125709 TVISQSLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVISQSLSK 9 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 2424120.0 531330.0 765990.0 1126800.0 False True 727777.0596533536 732146.029009804 860673.0471744495 1.0 1.0060031699247725 1.182605353876358 19.47313705097233 -6.914119969416212 0.8672056201233284 0.9952184642377038 1.2075600407471792 0.9923856977272317 0.007391047366685947 0.10175630209024883 0.12445487867808416 0.006177223847447614 0.017580369033596967 1.2186529120001016e-07 6.914119969416212 0.21234157650947538 TVISQSLSK(ub)YSNSDVIIYVGCGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVISQSLSKYSNSDVIIYVGCGER 24 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 116522000.0 13372000.0 19688000.0 83462000.0 True False 20286301.624147534 16174522.576953903 66965699.11730591 1.0 0.7973125351592314 3.301030437090325 24.274002536953287 -6.88728550490166 1.0382674022142573 0.8565890406005665 3.5052908748620477 0.9791046988774458 0.1641401799767251 0.1213748520806002 0.23491429271292716 0.12086109651673904 0.298520376457153 1.2963267864417062e-07 6.88728550490166 2.648701834261481 up TVISQSLSK(ub)YSNSDVIIYVGCGER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVISQSLSKYSNSDVIIYVGCGER 24 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 74488000.0 13372000.0 16430000.0 44686000.0 True False 17310317.601526782 15515656.05686926 36553606.51707958 1.0 0.8963241700141173 2.1116658491497304 24.045128859045736 -6.886160654176889 1.0448740264226226 0.9285616907120925 2.208642616612967 0.9783231514812091 0.08099325998965512 0.12231157719978128 0.24051133996707388 0.0593418611106032 0.14603024721299654 1.2996887083634344e-07 6.886160654176889 1.2800809259008745 up TVITEEFK(ub)VPDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVITEEFKVPDK 12 1 Q96I24;Q96I24-2 Q96I24 FUBP3 Far upstream element-binding protein 3 1 3739660.0 924160.0 1299900.0 1515600.0 True False 894823.0466596076 1818956.8488889493 1118618.892974606 1.0 2.0327559238434367 1.250100673144744 19.771242888716436 -10.089689665947754 4.382239548761536 0.9999384154531054 1.6414282981537769 0.47245099594814777 0.319517668311611 46608719.5894055 35770731.196107835 25995.787342117008 0.10937939552787085 8.134115484928685e-11 10.089689665947754 0.6414898827006715 TVITEEFK(ub)VPDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVITEEFKVPDK 12 1 Q96I24;Q96I24-2 Q96I24 FUBP3 Far upstream element-binding protein 3 1 3018310.0 924160.0 1298000.0 796150.0 True False 768479.9872297422 1291007.416367171 962621.2840183153 1.0 1.6799492996832146 1.252630257150123 19.551648164150713 -10.117502207671361 4.202988423287354 0.9999177323547264 1.4662897781805984 0.6135442031220777 0.1744522689111066 122605917.01838914 203730620.8176201 144932.86939346942 0.06384300002676699 7.629530127935883e-11 10.117502207671361 0.466372045825872 TVITEEFK(ub)VPDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVITEEFKVPDK 12 1 Q96I24;Q96I24-2 Q96I24 FUBP3 Far upstream element-binding protein 3 1 16410900.0 2602200.0 5581600.0 8227100.0 True False 3368599.1970305834 5270979.053379266 6729852.217174625 1.0 1.5647391527094194 1.9978192190709367 21.68371735312523 -6.974078115115687 0.12743993014446556 0.3032737414974856 3.270472006611953 0.9999992845530344 0.00034551019811086055 0.07500019848061246 0.0038177541044600674 0.028031239926450104 0.05994981785027898 1.0615046106944447e-07 6.974078115115687 2.9671982651144675 TVIVHGFTLGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVIVHGFTLGEK 12 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 17573000.0 5767200.0 6434700.0 5371100.0 False True 7560855.04964425 5474667.84226415 4815350.095229262 1.0 0.7240805181844799 0.6368790386288163 22.85011796595662 -13.999999999999998 0.1612182509938236 2.362422148391364 0.5522976063084962 0.9995332152500509 0.0033438997056774353 12.017999242616154 0.12692610417676173 5.119575637877121 0.07720779759419535 1.0000000000000041e-14 13.999999999999998 -1.810124542082868 TVIVHGFTLGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVIVHGFTLGEK 12 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 13889200.0 4401700.0 2744800.0 6742700.0 False True 4261970.4428687645 3840812.953942905 4976584.593335895 1.0 0.9011824472807993 1.1676722445747696 22.02308915726541 -6.806277767389734 1.429895958038358 0.945904073679936 1.1719580064566943 0.8499555189343513 0.04260829196828338 0.2119116528280348 0.8545780022298833 0.023434127189367653 0.05431070163989943 1.5621481995501348e-07 6.806277767389734 0.22605393277675834 TVIVHGFTLGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVIVHGFTLGEK 12 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 15405600.0 4626400.0 5856900.0 4922300.0 False True 7018587.0351448 4811690.4348314395 3949405.2474792646 1.0 0.6855639761589377 0.5627066000183589 22.74274918923201 -13.999999999999215 0.12993797947521624 2.4942602880651177 0.3905177035455592 0.9996458966715839 0.00346519689488481 11.936819494397572 0.11209125327214498 4.5556857721371 0.15312929916390597 1.0000000000018079e-14 13.999999999999215 -2.1037425845195585 TVIVHGFTLGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVIVHGFTLGEK 12 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 19734600.0 5767200.0 6216900.0 7750500.0 False True 7899489.692719818 5942216.80146092 5919991.526558016 1.0 0.7522279327659958 0.7494144250879762 22.913328027479512 TVIVHGFTLGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVIVHGFTLGEK 12 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 10428600.0 4401700.0 3942500.0 2084400.0 False True 3660208.578372964 3921260.9699750203 2520238.4028233085 1.0 1.0713217255280296 0.6885504880007698 21.803494432699686 -6.858574919054602 1.193087040402383 1.0385552140859837 0.6705291828827213 0.9518608182760232 0.036465307773245866 0.14828292208092791 0.4019215089113602 0.02385302173722294 0.055587530103341574 1.3849212560152248e-07 6.858574919054602 -0.3680260312032624 TVIVHGFTLGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVIVHGFTLGEK 12 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 17447700.0 4626400.0 8125200.0 4696100.0 False True 5988965.9999778345 7673025.477375172 3841457.98605508 1.0 1.2811936947719473 0.6414225737914186 22.51387551132446 -6.7872523454883025 1.5074794953251613 1.1577226797149685 0.6351409680153123 0.7922419274637273 0.11933953887019225 0.2394720668715089 1.075144686481077 0.062324816608443086 0.14620343166993982 1.632103343643557e-07 6.7872523454883025 -0.5225817116996562 TVK(ub)EFCQQEVEPMCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVKEFCQQEVEPMCK 15 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5GYJ8;F5H3F0;Q96FW1-2 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 1 4215700.0 2120900.0 0.0 2094800.0 True False 2780520.4388248194 0.0 1878050.1907404915 1.0 0.0 0.6754311763067798 21.406923511351817 -10.413903474709118 7.992118816639797 1.000013705392106 0.33771558815339 0.5617751919244904 0.2757436230532389 6.73394228558104e-05 4.938565300673082e-06 0.2669931219904279 0.08899587165900749 3.855640427190877e-11 10.413903474709118 -0.6622981172387161 TVK(ub)GGISETR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVKGGISETR 10 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;A0A3B3ITP0;P11171-6;E9PPC9;Q6R5J7;E9PN54;J3QS83;A8K968;A0A0A0MRA8;Q9Y2J2-2;Q9Y2J2;A0A0A0MSA4;Q9Y2J2-4;E9PII3;E9PK52;E9PHY5;O43491-2;O43491-3;O43491-4;O43491 P11171;A8K968 EPB41;EPB41L2;EPB41L3 Protein 4.1;Band 4.1-like protein 3;Band 4.1-like protein 3, N-terminally processed;Band 4.1-like protein 2 1 3724300.0 1499400.0 1641400.0 583500.0 True False 1246817.534682606 1632557.4524076106 705507.152200826 1.0 1.3093796060729925 0.5658463508699548 20.249818918958766 -6.793700223595842 1.4815667462787705 1.1720847839460211 0.5571183648169425 0.813071950724589 0.13185325658850205 0.22988170865235058 0.9967331885215904 0.07003671029899926 0.16353873359629145 1.6080508442835682e-07 6.793700223595842 -0.6149664191290786 TVK(ub)GPDGLTAFEATDNQAIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVKGPDGLTAFEATDNQAIK 20 1 P58546;C9JL85 P58546 MTPN Myotrophin 1 23932000.0 3458300.0 5830700.0 14643000.0 True False 4476837.523284484 5506216.4194027735 11978124.249867894 1.0 1.229934388005905 2.675577165257497 22.094048529154804 -6.934854221919473 0.7058168357200999 0.9814684221464933 3.0127114611538888 0.9974091341522926 0.03775004520536878 0.09019454004089124 0.065900496412839 0.03544577897135289 0.12749569103036423 1.1618385385947762e-07 6.934854221919473 2.0312430390073954 up TVK(ub)HFSTEDGIFQGQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVKHFSTEDGIFQGQR 16 1 Q6RFH5;Q6RFH5-2;E9PS41 Q6RFH5 WDR74 WD repeat-containing protein 74 1 49765500.0 2890100.0 4683400.0 42192000.0 True False 4384492.994611783 3847610.6784287808 33852732.70658942 1.0 0.877549737941698 7.721014208071931 22.0639785941039 -6.902826945469321 0.9432201336568227 0.7371200954782198 8.48206560390213 0.987921105707228 0.35142570561740005 0.1093543265507791 0.1659152049368383 0.27788040567810446 0.7338138373871771 1.250757323684082e-07 6.902826945469321 7.7449455084239105 up TVK(ub)HFSTEDGIFQGQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVKHFSTEDGIFQGQR 16 1 Q6RFH5;Q6RFH5-2;E9PS41 Q6RFH5 WDR74 WD repeat-containing protein 74 1 83269000.0 2890100.0 4426900.0 75952000.0 True False 3741291.4223880144 4180539.123442144 62129515.33333102 1.0 1.1174053692865669 16.60643567126204 21.83510491619635 -6.9085592386431305 0.905464463416281 0.49830061799290193 18.547820258805768 0.9903670155778354 0.7193670344266894 0.10537923401716942 0.14398245863323872 0.5847913776009648 1.5986720534581667 1.2343569349121195e-07 6.9085592386431305 18.049519640812864 up TVK(ub)KPGPNLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVKKPGPNLGR 11 2 Q9UBZ4 Q9UBZ4 APEX2 DNA-(apurinic or apyrimidinic site) lyase 2 1 2563590.0 1618400.0 494830.0 450360.0 True False 2095050.7034333642 467292.27550947096 368399.1010838285 1.0 0.22304580731324233 0.17584257053067828 20.998553729099253 -13.577217322095919 0.40231805468872295 9.999999993745469 0.1731660585515287 0.9998329481113224 0.004884006351650351 19.046141797065587 0.20877962025935093 147.79980511205662 0.01200521324886398 2.647175153742996e-14 13.577217322095919 -9.82683393519394 TVK(ub)NCLALADDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVKNCLALADDKK 13 2 O75367-2;O75367-3;O75367;B4DJC3 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 15165500.0 4208800.0 6607600.0 4349100.0 True False 5517777.558077175 5621771.836223068 3899096.8515130226 1.0 1.0188471313044618 0.7066426311088504 22.395655866840386 -6.892545342002952 1.0071735437568294 1.0157658341404436 0.6784086787443392 0.9824791045120976 0.018920408613252844 0.11710340726323525 0.2099642118135739 0.014263368993219436 0.035901703417667574 1.2807213753519526e-07 6.892545342002952 -0.33735715539610445 TVK(ub)NCLALADDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVKNCLALADDKK 13 2 O75367-2;O75367-3;O75367;B4DJC3 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 10933600.0 4498900.0 4282700.0 2152000.0 True False 4356084.882073349 5992804.4439854575 1588326.6413838442 1.0 1.3757317881126974 0.3646225187025865 22.05460063581085 -6.806073939515443 1.4308693199513327 1.2057426019941544 0.3484618087236962 0.8493504202061056 0.1619674747911408 0.212205975706664 0.8569821408269996 0.08902272562685741 0.20632794728470646 1.5628815362410116e-07 6.806073939515443 -0.8572807932704583 down TVK(ub)NCLALADDKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVKNCLALADDKK 13 2 O75367-2;O75367-3;O75367;B4DJC3 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 24493600.0 13094000.0 7217000.0 4182600.0 True False 19864555.299625166 5929069.963321625 3355907.2767012995 1.0 0.29847483992926355 0.1689394615727755 24.2436931609244 -13.999999999999998 0.23757102910693753 5.589376932613335 0.11032989791684407 0.9995210161640734 0.007990122035775498 13.538905975238311 0.15427985737516467 29.436216542649746 0.06421198109314886 1.0000000000000041e-14 13.999999999999998 -5.479047034696491 TVK(ub)NCLALADDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVKNCLALADDKK 13 2 O75367-2;O75367-3;O75367;B4DJC3 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 12645900.0 4208800.0 5484700.0 2952400.0 True False 5764907.098543337 5242367.818522522 2255103.926586658 1.0 0.9093585948413898 0.3911778434654173 22.458865928363277 -6.936866836999646 0.6880957393662219 1.0062505270409283 0.2634452772089073 0.9977240206478738 0.012795179453364959 0.08922558670479051 0.061339810391590886 0.012177174596866881 0.04524865911083246 1.1564667826847003e-07 6.936866836999646 -0.742805249832021 down TVK(ub)NCLALADDKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVKNCLALADDKK 13 2 O75367-2;O75367-3;O75367;B4DJC3 O75367-2 H2AFY Core histone macro-H2A.1;Histone H2A 1 10453000.0 4498900.0 3916600.0 2037500.0 True False 3741034.685063069 3895500.498415764 2463531.8296644054 1.0 1.041289596690839 0.6585161692032998 21.835005911245126 -6.880190266475784 1.0786993690491846 1.0256576546386853 0.6312859388531554 0.9738402145218069 0.027744740908064572 0.12746343877550378 0.271247871662971 0.019809188259000972 0.047928451344217284 1.317679330508262e-07 6.880190266475784 -0.3943717157855299 TVLAPGNDRNSDTAENLLLDAEANIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVLAPGNDRNSDTAENLLLDAEANIK 26 1 Q6IPE9 Q6IPE9 MARK4 0 60609000.0 18286000.0 26922000.0 15401000.0 False True 27741198.885668673 22117558.75745395 12356985.599501908 1.0 0.7972820082004479 0.4454380522784697 24.72552680187427 -6.962719984861804 0.39523978860711545 1.0203866023115253 0.20958463009582545 0.9998581505959119 0.002728721491609956 0.07874347674555335 0.017643537782587194 0.004532098084096731 0.02953281542661704 1.0896324168565784e-07 6.962719984861804 -0.8108019722156998 down TVLAPGNDRNSDTAENLLLDAEANIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVLAPGNDRNSDTAENLLLDAEANIK 26 1 Q6IPE9 Q6IPE9 MARK4 0 42929400.0 18286000.0 18817000.0 5826400.0 False True 23671587.470948137 17769817.408527628 4766054.983912463 1.0 0.750681272658047 0.20134074192370016 24.49665312396672 -7.108533535843647 0.5115036545212578 1.0092683933287836 4.11315559591993e-22 0.9993943809596497 0.008210451882369693 0.07723777072389378 0.03187786340503163 0.009365122679485728 0.04289169776741975 7.788726683587989e-08 7.108533535843647 -1.0092683933287836 down TVLCGTCGQPADK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVLCGTCGQPADK 13 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 0 5252210.0 893110.0 2587000.0 1772100.0 False True 1170875.8588895435 2201029.6840470205 1588740.0911835146 1.0 1.8798147278691637 1.3568817557569877 20.15915669276498 -10.394446035803629 5.188931888856152 0.9995542874595073 1.6183482418131028 0.6508730655893809 0.2134864918920778 0.0011015530211098562 0.0001285525642669603 0.20685046392007064 0.06890246897817484 4.032310476731193e-11 10.394446035803629 0.6187939543535955 TVLCGTCGQPADK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVLCGTCGQPADK 13 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 0 18153700.0 2534400.0 13801000.0 1818300.0 False True 3844870.089458538 11338103.72229484 1458912.2080107986 1.0 2.948891239103361 0.37944382360555984 21.874503422528132 -6.703867349595602 1.8170142232650315 2.2055354828295095 0.3864655946587494 0.43605703845652677 0.8220779415725797 0.38748599937691086 2.4897168455049754 0.36057795006576304 0.9229320436333976 1.9775735756608508e-07 6.703867349595602 -1.81906988817076 TVLCGTCGQPADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVLCGTCGQPADK 13 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 0 4921210.0 893110.0 2334500.0 1693600.0 False True 1223316.9023902405 2231354.0708408537 1293606.5607868752 1.0 1.8240196522103211 1.0574582581662166 20.222366754287872 -10.223651099616067 4.145787602022817 0.9997428890750228 1.4407389547765201 0.30592458787712473 0.3129473788092087 43745175.8373751 53938843.41303419 85571.86878805935 0.10713020966565925 5.975151212246887e-11 10.223651099616067 0.4409960657014973 TVLCGTCGQPADK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVLCGTCGQPADK 13 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 0 6518300.0 2534400.0 2030100.0 1953800.0 False True 3280830.760492786 1917123.1503986763 1598228.44768093 1.0 0.5843407631641205 0.48714138715307387 21.64562974462058 -13.999999999999998 0.2041417958379036 3.347912057861845 0.42653071574244655 0.999487573850042 0.005034928120646546 12.615871098297662 0.1432449908668723 11.848476595826442 0.060033366177332376 1.0000000000000041e-14 13.999999999999998 -2.9213813421193984 TVLCGTCGQPADK(ub)ASASGSGAQVGGPISSGSSASSVTVTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVLCGTCGQPADKASASGSGAQVGGPISSGSSASSVTVTR 40 1 P02545;P02545-3;P02545-5;P02545-4;A0A0C4DGC5 P02545 LMNA Prelamin-A/C;Lamin-A/C 1 29151000.0 8928000.0 6018000.0 14205000.0 True False 13544428.724228924 4944040.881151391 11397375.523727331 1.0 0.36502395057144443 0.8414807117954823 23.69119620916507 -9.904375449234514 6.5128261950192945 1.0000000290336801 0.6032523311835302 0.48039233192611297 0.1945126582497265 8.188878607726651e-08 1.421995215160743e-08 0.18833608553899783 0.06277869050230102 1.2463056124338822e-10 9.904375449234514 -0.39674769785014996 TVLDK(ub)AVQADGQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVLDKAVQADGQVK 14 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 7511500.0 2462500.0 2089200.0 2959800.0 True False 2384329.285404354 2923428.455034069 2184539.5879032984 1.0 1.2261009722649487 0.9162071704088585 21.185152060835094 -6.711103706201911 1.7913636035843796 1.138847495541365 0.9169149464680652 0.4702635636703093 0.09526174717229466 0.3728807480410775 2.3332030429141017 0.04230881382538299 0.10733691994890421 1.9448955999678253e-07 6.711103706201911 -0.22193254907329985 TVLDK(ub)AVQADGQVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVLDKAVQADGQVK 14 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 34378000.0 7367100.0 14270000.0 12740900.0 True False 11176429.307153545 11723407.007981116 10222655.530465152 1.0 1.0489402908384589 0.9146620310944995 23.413956007699138 -6.80805880444251 1.4225046644183965 1.0267336428347393 0.9124117556458711 0.8547532592307894 0.02114644828335479 0.20945131533319244 0.8356603649185027 0.011689766540513872 0.027067556363854776 1.5557549646472218e-07 6.80805880444251 -0.11432188718886827 TVLDK(ub)AVQADGQVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVLDKAVQADGQVK 14 1 Q8WUM4;Q8WUM4-2 Q8WUM4 PDCD6IP Programmed cell death 6-interacting protein 1 15155800.0 7367100.0 5618100.0 2170600.0 True False 9536856.17725156 5305447.796293186 1775573.0722367843 1.0 0.5563099304096006 0.18618012469057588 23.185082329791587 -7.890649749384366 0.33853956761278997 1.0871860877339854 1.5642502371260599e-21 0.9988534725571312 0.011265109262055905 0.10851711904456111 0.06160915048393707 0.0444292462302643 0.08389808393967016 1.2863236383981867e-08 7.890649749384366 -1.0871860877339854 down TVLDPVTGDLSDTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVLDPVTGDLSDTR 14 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 11113100.0 0.0 3209400.0 7903700.0 False True 0.0 4490930.156799904 5833483.864082479 0.0 TVLDQQQTPSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVLDQQQTPSR 11 0 P42704 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 13825600.0 2862600.0 10963000.0 0.0 False True 4342773.484092487 9006566.995690038 0.0 1.0 2.0739205092508177 0.0 22.050185274153982 -6.770998396944618 1.6034659051529847 1.6189116297702102 4.5941291877051844e-10 0.7146806373853791 0.4523494223232987 0.269381103714017 1.3723583387606801 0.22355526479120635 0.5246767915070392 1.694344054550145e-07 6.770998396944618 -1.6189116293107972 TVLDQQQTPSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVLDQQQTPSR 11 0 P42704 P42704 LRPPRC Leucine-rich PPR motif-containing protein, mitochondrial 0 6602400.0 2862600.0 1946800.0 1793000.0 False True 3705692.130281975 1838458.8686252641 1466692.3977335994 1.0 0.49611754133643354 0.39579445517023976 21.82131159624643 -13.999999999999986 0.2268971007317529 4.135862289765614 0.34555376175446934 0.9995057167692027 0.005877612869296897 13.196523757743057 0.150845858841912 18.611133740932495 0.053100713714319764 1.0000000000000327e-14 13.999999999999986 -3.790308528011144 TVLEHYALEDDPLAAFK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVLEHYALEDDPLAAFKQR 19 1 Q3ZCQ8;Q3ZCQ8-2;M0R0C3;M0R2F8;Q3ZCQ8-3 Q3ZCQ8 TIMM50 Mitochondrial import inner membrane translocase subunit TIM50 1 7761800.0 1581000.0 1650700.0 4530100.0 True False 2165538.4249185105 1577766.6158650664 3460183.68033811 1.0 0.7285793674727512 1.5978398907737308 21.046294340874223 -6.822800700255159 1.3596617700383327 0.8541043124308636 1.6179890137066966 0.8907127473755557 0.12004198169662114 0.18986813169990527 0.688920955511071 0.06936418449496666 0.15977050440790166 1.5038319231851865e-07 6.822800700255159 0.763884701275833 TVLELQYVLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVLELQYVLDK 11 0 Q14444-2;Q14444;G3V153;E9PLA9 Q14444-2 CAPRIN1 Caprin-1 0 15292700.0 4912400.0 5256300.0 5124000.0 False True 4756458.550911816 7355168.001242387 3781870.683294987 1.0 1.5463538518237265 0.7951022053098729 22.181456375500428 -6.711693425227779 1.7893905501232408 1.3353057713228713 0.7967939941896597 0.47306469498329984 0.23017026134856394 0.3716695393039906 2.320890404604213 0.10232820963275398 0.2594077250667035 1.9422564607777588e-07 6.711693425227779 -0.5385117771332116 TVLELQYVLDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVLELQYVLDK 11 0 Q14444-2;Q14444;G3V153;E9PLA9 Q14444-2 CAPRIN1 Caprin-1 0 39485000.0 8871700.0 20676000.0 9937300.0 False True 13459017.508147588 16986206.25767466 7973188.299326691 1.0 1.2620688135216291 0.5924049281086097 23.682069763026224 -6.800562855719649 1.4536273743633275 1.1444922711071552 0.5830333444032595 0.8337980901590782 0.11232873509003188 0.2199565191902005 0.9175243449913927 0.06079024908628263 0.14132663150497565 1.5828404646094667e-07 6.800562855719649 -0.5614589267038957 TVLELQYVLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVLELQYVLDK 11 0 Q14444-2;Q14444;G3V153;E9PLA9 Q14444-2 CAPRIN1 Caprin-1 0 12440800.0 4912400.0 3458300.0 4070100.0 False True 4084878.2562190443 3439669.451481197 4921139.091983852 1.0 0.8420494408234699 1.204721116104657 21.961861650934704 -6.78830739720983 1.5028883028084197 0.9115289756314509 1.2084120918790604 0.795878918356389 0.06707835574129553 0.2378699134098628 1.0613911609835278 0.03513359099317656 0.08236597859734872 1.62814321153012e-07 6.78830739720983 0.29688311624760955 TVLELQYVLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVLELQYVLDK 11 0 Q14444-2;Q14444;G3V153;E9PLA9 Q14444-2 CAPRIN1 Caprin-1 0 27798300.0 8871700.0 10716000.0 8210600.0 False True 11484590.537351558 10119645.179878948 6716355.047870325 1.0 0.8811498456968604 0.5848144978287726 23.453196085118673 -6.955518906621251 0.49456316237820597 1.0062248141504098 0.44707595647839404 0.9995662083495666 0.0036361914043141507 0.08134247957554977 0.02735527230823965 0.004309216375853676 0.02444170074859717 1.1078503350524843e-07 6.955518906621251 -0.5591488576720157 TVLGQQILGQLDSSSLALPSEAKLK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVLGQQILGQLDSSSLALPSEAKLK 25 1 Q99959-2;Q99959 Q99959-2 PKP2 Plakophilin-2 1 5460700.0 0.0 3633800.0 1826900.0 True False 0.0 3614223.998147173 2208896.343368788 0.0 TVLGTPEVLLGALPGAGGTQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVLGTPEVLLGALPGAGGTQR 21 0 H0YFD6;P40939;A0A2R8YG21;A0A2R8Y688 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 4370290.0 683190.0 2264900.0 1422200.0 False True 895668.7060213708 1926985.7485110543 1275044.3867057152 1.0 2.1514492306769015 1.4235669708385372 19.77260567484085 -10.134915466573625 4.768520356197363 0.9999533370344926 1.7875081007594111 0.6094856711584624 0.2971566883449949 207561799.48002547 14.663051513184351 134530.74343385958 0.10172463830815208 7.329671879518332e-11 10.134915466573625 0.7875547637249185 TVLGTPEVLLGALPGAGGTQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVLGTPEVLLGALPGAGGTQR 21 0 H0YFD6;P40939;A0A2R8YG21;A0A2R8Y688 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 10485000.0 4880300.0 2003800.0 3600900.0 False True 4725377.547841162 2803927.7896789555 2657716.265315555 1.0 0.5933764574980805 0.5624346919178469 22.171998171597124 -13.999999999999998 0.3653456123279823 6.500965872005794 0.5589896096360129 0.9997828263328226 0.0029381874740369114 22.285951287902446 0.19578744694364 95.81721645277477 0.008775842194876862 1.0000000000000041e-14 13.999999999999998 -5.9419762623697805 TVLGTPEVLLGALPGAGGTQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVLGTPEVLLGALPGAGGTQR 21 0 H0YFD6;P40939;A0A2R8YG21;A0A2R8Y688 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 7948390.0 683190.0 3051400.0 4213800.0 False True 935783.8055155443 2916579.0583695793 3218587.2259351253 1.0 3.1167231588954145 3.4394560014446216 19.83581573636374 -10.101767268779557 0.4324787358295681 4.080068371417809e-21 3.4564455718963334 0.9990873726511618 0.032685528123626094 1.4295315572539622 0.19698147917528422 1.864604119946959 0.07543247787474336 7.911024531323271e-11 10.101767268779557 3.4564455718963334 TVLIACNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVLIACNVK 9 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 21009200.0 3747900.0 8168500.0 9092800.0 False True 4913533.194715224 6949791.640563619 8151964.280296512 1.0 1.4144183757705155 1.6590839946017661 22.228329371741594 -9.90358474764307 0.10461490821603951 4.491418672595529e-18 2.303329578782222 0.9999209672162626 0.002418336978005768 1.484038273976663 0.047964980888617344 0.736881284611015 0.3390985015539874 1.2485767752181897e-10 9.90358474764307 2.303329578782222 TVLIACNVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVLIACNVK 9 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 16036400.0 3747900.0 4908000.0 7380500.0 False True 5133599.913189166 4691148.3314144 5637377.90616882 1.0 0.9138126092300207 1.0981334738777278 22.291539433264486 -6.779588500124073 1.5378029699206122 0.9511717304077801 1.0995661705255821 0.7658131318890884 0.03644046996877077 0.25121946887422797 1.1734760228306422 0.018665619622775496 0.044052152942164136 1.6611601336125214e-07 6.779588500124073 0.148394440117802 TVLIACNVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVLIACNVK 9 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 14086600.0 6041900.0 4449500.0 3595200.0 False True 7821358.653654262 4201881.413575149 2940910.489867176 1.0 0.537231649850498 0.3760101818746205 22.898987810185737 -13.999999999999998 0.14703661625424877 3.228098948310716 0.19244582091747506 0.9995764302042017 0.005443050689907367 11.947809784108104 0.12060347562917294 7.6132396205066035 0.16500241118237366 1.0000000000000041e-14 13.999999999999998 -3.035653127393241 TVLIACNVK(ub)QMSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVLIACNVKQMSK 13 1 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 1 23280900.0 4948300.0 8541100.0 9791500.0 True False 6487269.219405358 7266801.172947041 8778369.506700188 1.0 1.120163342567913 1.3531686769590918 22.62917988072278 -6.960645506229197 0.4262404102951473 0.9903670237921189 1.4918451298550557 0.9997933905283986 0.002107397724593515 0.07947135843615415 0.020285381498206342 0.003028066238668628 0.019364141958625996 1.0948496749559052e-07 6.960645506229197 0.5014781060629367 TVLIACNVK(ub)QMSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVLIACNVKQMSK 13 1 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 1 9258400.0 3985500.0 2924400.0 2348500.0 True False 3858982.4840524024 4092128.170544532 1733357.3965102036 1.0 1.0604163629805592 0.44917472511820444 21.879789064815654 -6.882594453877285 1.0651787751173547 1.0389059052890535 0.40363410183030657 0.975720495509584 0.042851747611820964 0.12535872260697342 0.2585850902878413 0.030912874168319303 0.07527614539013709 1.3104050138886995e-07 6.882594453877285 -0.6352718034587469 down TVLIACNVK(ub)QMSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVLIACNVKQMSK 13 1 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 1 42596000.0 13010000.0 12197000.0 17389000.0 True False 19737121.158402618 10020350.05440404 13952056.528130557 1.0 0.507690558009171 0.7068942028655884 24.234408238941043 -10.196278106098719 5.422997794443369 1.0000171983692816 0.6072923804373238 0.838235499719586 0.08132454746699996 1.6910900396370488e-05 2.5063807294488878e-06 0.07874559818382323 0.026247384831433608 6.363878711808506e-11 10.196278106098719 -0.3927248179319578 TVLIACNVK(ub)QMSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVLIACNVKQMSK 13 1 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 1 19241300.0 4948300.0 7479100.0 6813900.0 True False 6777820.232779409 7148648.631923678 5204597.1566755315 1.0 1.0547120440508058 0.7678865738434111 22.692389942245672 -6.857305293490892 1.1992088013220272 1.0294989441143387 0.7546907762807898 0.9502857972964761 0.02772319371844756 0.1496060152840322 0.4103561664739356 0.018048983481788954 0.04201389178907602 1.3889758875649155e-07 6.857305293490892 -0.2748081678335489 TVLIACNVK(ub)QMSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVLIACNVKQMSK 13 1 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 1 10847900.0 3985500.0 2100900.0 4761500.0 True False 3314119.8375867163 2089582.0347039995 5757107.635311452 1.0 0.6305088943994241 1.737145280631637 21.66019434024993 -6.816674791373875 1.386175018436337 0.8001566614840768 1.7596307596255116 0.8765829756248587 0.16160789608202228 0.19782796279379983 0.7477955841467592 0.09163646563049573 0.21141989685769624 1.5251944231945893e-07 6.816674791373875 0.9594740981414348 TVLIACNVK(ub)QMSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVLIACNVKQMSK 13 1 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 1 32088400.0 13010000.0 11680000.0 7398400.0 True False 16841701.46544001 11029997.732454829 6051967.113994582 1.0 0.6549218174356624 0.3593441628456313 24.005534561033492 -7.475631401258123 0.22960052712324958 1.1548044087066562 9.825417181127316e-17 0.9999168694094627 0.0023870417459542306 0.12569019066386602 0.02105610405915013 0.027122331495646697 0.06317119535781117 3.3447880177337165e-08 7.475631401258123 -1.1548044087066562 down TVLIACNVKQMSK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVLIACNVKQMSK 13 1 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 1 12031400.0 5756300.0 1349200.0 4925900.0 True False 8732727.941899521 1108424.7186522854 3952293.7059013345 1.0 0.12692765949275453 0.45258408737758543 23.058000964700533 -10.510093312556197 6.196902055553089 1.0006538887905234 0.28975587373760187 0.8637996304900408 0.13294867996255058 0.0012020596983980687 9.503080133073151e-05 0.12883423817636444 0.042909001949601504 3.089631522651608e-11 10.510093312556197 -0.7108980150529216 TVLIMELINNVAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 TVLIMELINNVAK 13 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 170665620.0 81215930.0 48502090.0 40947600.0 False True 106474870.72618484 41265767.23166604 36710735.149114646 1.0 0.3875634405585407 0.3447830919985006 26.665937737375923 -13.999999999999998 0.3779164268088682 9.96745152507567 0.3408867094458988 0.9998041393340001 0.0041886894494723124 23.774405485570053 0.20028257492600485 173.30025304961762 0.011668565498241107 1.0000000000000041e-14 13.999999999999998 -9.626564815629772 TVLIMELINNVAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 TVLIMELINNVAK 13 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 788169620.0 350179000.0 183552020.0 254438600.0 False True 339062759.3232933 256845298.7971392 187793497.6656169 1.0 0.7575155092519007 0.5538605833339469 28.33697709495141 -6.973139486475494 0.1669464012825699 1.1875064866688732 0.11843139946345273 0.9999976586512899 0.0002789861545405794 0.07529650810391639 0.005190597351999873 0.00882832399801565 0.023841018623662082 1.0638012922046144e-07 6.973139486475494 -1.0690750872054204 TVLIMELINNVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVLIMELINNVAK 13 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 13976600.0 6640900.0 7335700.0 0.0 False True 10074730.81482212 6026587.020914294 0.0 1.0 0.5981883915000362 0.0 23.26423795633358 -7.656249589062217 0.6600560268333947 0.9985336508603835 2.064507657391337e-15 0.9872945347915669 0.04631196543958974 0.1209243372340857 0.1491087694089349 0.042585522974206924 0.07762404662737256 2.206736157139754e-08 7.656249589062217 -0.9985336508603814 down TVLIMELINNVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TVLIMELINNVAK 13 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 281666930.0 81215930.0 66802200.0 133648800.0 False True 111243654.09898278 63850657.91866569 102083706.02343684 1.0 0.5739712385018603 0.9176586911879435 26.729147798898815 -9.921208236226336 6.629206076838048 1.0000000179315183 0.7458149648448967 0.4217342140643361 0.14030981501299233 3.713647596968403e-08 6.1074840748970315e-09 0.1358544043356136 0.04528479807122741 1.198924303129611e-10 9.921208236226336 -0.25418505308662154 TVLIMELINNVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TVLIMELINNVAK 13 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 614282300.0 350179000.0 138453400.0 125649900.0 False True 291189354.0600372 137707524.0533517 151922713.15050307 1.0 0.4729140064130204 0.5217316877566196 28.117382370385688 -10.304305667122101 8.764073536156522 1.0000004019508646 0.4973228479541403 0.9929761356728559 0.01992973495293401 1.5652173978260062e-07 1.243486741871292e-08 0.019296898130425368 0.0064322942972534535 4.962429305481756e-11 10.304305667122101 -0.5026775539967243 TVLIMELINNVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVLIMELINNVAK 13 0 P06576;H0YH81;F8W079;F8W0P7;H0YI37 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 18168700.0 6640900.0 7703700.0 3824100.0 False True 8596775.961709484 7274982.322903445 3128153.0385795133 1.0 0.8462454244831572 0.36387513790198556 23.03536427842603 -6.950440730268934 0.5539850696085298 1.006518816589027 0.18078529033807753 0.9992354100840777 0.007493520109345496 0.0833092692258689 0.035233830838099625 0.008092272250618393 0.04004770875886637 1.120880386279509e-07 6.950440730268934 -0.8257335262509495 down TVLK(ub)LASEEPPDDEEALATIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVLKLASEEPPDDEEALATIR 21 1 Q9UBB4;Q9UBB4-2;B1AHE4 Q9UBB4 ATXN10 Ataxin-10 1 33242100.0 7602100.0 13046000.0 12594000.0 True False 9966426.718841134 11099587.652909711 11290893.690178426 1.0 1.1136978142754395 1.1328928620759775 23.248644914565425 -13.999999999997547 0.2502868155951481 0.2081403133958251 1.1405898617100907 0.9995432190288869 0.0012534345244566351 14.008641556422173 0.15829893978132611 5.578029642822269 0.008843817107696026 1.0000000000056486e-14 13.999999999997547 0.9324495483142656 TVLK(ub)LASEEPPDDEEALATIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVLKLASEEPPDDEEALATIR 21 1 Q9UBB4;Q9UBB4-2;B1AHE4 Q9UBB4 ATXN10 Ataxin-10 1 144361000.0 40560000.0 51097000.0 52704000.0 True False 61532485.333190575 41978341.127316765 42287031.29901624 1.0 0.6822142954247564 0.6872309979035846 25.874844929226587 -9.953935963005787 6.217768845377555 1.0000000987434743 0.684722646664255 0.9998101400376277 0.002048060210838691 2.8023727035406256e-09 4.704888818591227e-10 0.0019830263926450304 0.0006610085907039472 1.1118956649093092e-10 9.953935963005787 -0.3152774520792193 TVLK(ub)LASEEPPDDEEALATIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVLKLASEEPPDDEEALATIR 21 1 Q9UBB4;Q9UBB4-2;B1AHE4 Q9UBB4 ATXN10 Ataxin-10 1 141439000.0 40560000.0 51130000.0 49749000.0 True False 52505719.557128824 48284570.55311777 40695192.46784654 1.0 0.9196059202765855 0.7750620848756897 25.645971251319036 -6.962073149969999 0.40516059201533655 1.0075073260718843 0.6818385627160837 0.9998395206945194 0.0011789625614675252 0.07896871951437825 0.018455074866274564 0.0018596475157364972 0.01208792526246266 1.0912565162350917e-07 6.962073149969999 -0.32566876335580064 TVLLPK(ub)SGGVVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVLLPKSGGVVER 13 1 Q92989;Q92989-2;E9PL17 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 8339800.0 1646000.0 2928300.0 3765500.0 True False 2254570.6814774587 2798918.0234068455 2876166.452906812 1.0 1.2414416839540674 1.275704716882955 21.104421308937475 -12.867402902601743 0.29184023470927223 2.843909810559936e-05 1.285230341078488 0.9995587753412558 0.0025771930649277756 8.449690986177803 0.1673170875392126 5.004566601386566 0.012835974290438498 1.357053899740895e-13 12.867402902601743 1.2852019019803824 TVLLPK(ub)SGGVVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVLLPKSGGVVER 13 1 Q92989;Q92989-2;E9PL17 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 11119600.0 3014900.0 5216300.0 2888400.0 True False 2507022.932716144 5188198.756545518 3492351.085547326 1.0 2.069466014387252 1.3930271797568536 21.257543762450368 -10.130092335649378 4.860905590406119 0.9999567971796024 1.7312465970758766 0.6090925757633074 0.27615499785443587 0.00012930716302840336 2.3140502421094002e-05 0.2674016573694523 0.08912864230330013 7.41152647572801e-11 10.130092335649378 0.7312897998962742 TVLLPK(ub)SGGVVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVLLPKSGGVVER 13 1 Q92989;Q92989-2;E9PL17 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 13387400.0 4084000.0 3621900.0 5681500.0 True False 5286818.507675397 3420338.081094022 4647525.297112911 1.0 0.64695583480469 0.8790778972960087 22.333968370306135 -10.574729810876931 5.037224671487099 1.0017081891135433 0.7630168660503464 0.5815484772703923 0.09476343519103732 0.001830284237605098 0.0001545224989254103 0.0923794132602849 0.0305847671936896 2.66238090087561e-11 10.574729810876931 -0.23869132306319696 TVLPFVSTVPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVLPFVSTVPSK 12 0 P26010;P26010-2;F5H6T4 P26010 ITGB7 Integrin beta-7;Integrin beta 0 5338100.0 2433800.0 1151300.0 1753000.0 False True 2356540.3511947636 1611020.093950184 1293836.7111272668 1.0 0.6836378138542795 0.5490407624343427 21.168238954250608 -13.999999999999993 0.11679673718986004 2.5121318082433732 0.3246419399634966 0.9997087933130395 0.0032256224673929226 11.977158310864553 0.1047510727423999 4.222759255658579 0.19911914237512368 1.0000000000000164e-14 13.999999999999993 -2.1874898682798767 TVLPFVSTVPSK(ub)LR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVLPFVSTVPSKLR 14 1 P26010;P26010-2;F5H6T4 P26010 ITGB7 Integrin beta-7;Integrin beta 1 121661000.0 2805500.0 5585500.0 113270000.0 True False 3678037.668500651 4752165.172108476 101549906.96256241 1.0 1.2920382009153517 27.60980612902726 21.81050482446304 -6.909324708708048 0.9003198401134788 0.16763863340596355 30.962276685697198 0.9906642173279933 1.2054270551703061 0.10486643386577271 0.1412016686016458 0.9836147472443181 2.7026894344063166 1.232183223013061e-07 6.909324708708048 30.794638052291234 up TVLPFVSTVPSK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVLPFVSTVPSKLR 14 1 P26010;P26010-2;F5H6T4 P26010 ITGB7 Integrin beta-7;Integrin beta 1 376151600.0 5774600.0 13297000.0 357080000.0 True False 5591288.483856229 18606561.44293894 263550035.82962 1.0 3.32777704041954 47.13583221301675 22.4147493524047 -6.917702059110329 0.8418326170103186 4.150997197826144e-14 53.83440324990956 0.9935926252218891 1.698679153889522 0.0991802206856209 0.11243260974272906 1.4488497786127568 4.247592143147178 1.2086427210562418e-07 6.917702059110329 53.83440324990952 up TVLPFVSTVPSK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVLPFVSTVPSKLR 14 1 P26010;P26010-2;F5H6T4 P26010 ITGB7 Integrin beta-7;Integrin beta 1 1749207900.0 5157900.0 376650000.0 1367400000.0 True False 7824911.3929996 309433864.72011805 1097132790.6472905 1.0 39.54471164963566 140.21025102326632 22.89964298480664 -6.96367114166665 0.5157700914113542 3.4075494379155084e-16 183.2553645552623 0.9994910966986293 1.323940285756916 0.08082158760895979 0.029780311834999344 1.5327367576446684 8.193144329690965 1.0872486030458369e-07 6.96367114166665 183.2553645552623 TVLPFVSTVPSK(ub)LR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVLPFVSTVPSKLR 14 1 P26010;P26010-2;F5H6T4 P26010 ITGB7 Integrin beta-7;Integrin beta 1 227488800.0 2805500.0 6413300.0 218270000.0 True False 3842769.16578677 6129939.200052972 166719121.41175672 1.0 1.5951879843914396 43.38515123315313 21.873714885985933 -6.908163037594814 0.9089976929677616 1.5234378730198264e-17 48.56310851443277 0.9910064847984432 1.8816756597294089 0.10287414146764136 0.14198254389645507 1.5460939703569305 4.211068282954147 1.2354835360510663e-07 6.908163037594814 48.56310851443277 up TVLPFVSTVPSK(ub)LR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVLPFVSTVPSKLR 14 1 P26010;P26010-2;F5H6T4 P26010 ITGB7 Integrin beta-7;Integrin beta 1 309133600.0 5774600.0 16019000.0 287340000.0 True False 4801835.758155376 15932702.467477454 347421465.4899486 1.0 3.3180440293938744 72.35180105856233 22.195154627838978 -6.911000327220998 0.8907505521824034 3.038969589728843e-14 81.40699159833272 0.9923620624601006 2.8930222359522713 0.09968058082178667 0.13060852039839957 2.4290488308376545 6.736350883131474 1.2274383063395204e-07 6.911000327220998 81.4069915983327 up TVLPFVSTVPSK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVLPFVSTVPSKLR 14 1 P26010;P26010-2;F5H6T4 P26010 ITGB7 Integrin beta-7;Integrin beta 1 999767900.0 5157900.0 252030000.0 742580000.0 True False 6677003.227409143 238004308.9478249 607438059.514231 1.0 35.64537874877993 90.97465417130452 22.67076930689909 -7.111022885875735 0.42425357087816773 1.0918160212588594e-14 120.59937697093122 0.9991802341791136 1.0609169579136317 0.11863454385289196 0.03445266243694759 1.3031203921476406 7.032330490772427 7.744209873151458e-08 7.111022885875735 120.5993769709312 TVLQRPLSLIQGPPGTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVLQRPLSLIQGPPGTGK 18 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 10511900.0 3702000.0 3595100.0 3214800.0 False True 4853357.850219001 3058725.093590041 2882163.334539115 1.0 0.6302286350988976 0.593849335550038 22.210551806863535 -13.999999999999998 0.32784602278933916 4.973384689527383 0.5872429730501673 0.9997103528117651 0.003122792024603212 18.64297376637896 0.1829825785726305 51.01994616319369 0.011752482043768183 1.0000000000000041e-14 13.999999999999998 -4.386141716477216 TVLQRPLSLIQGPPGTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVLQRPLSLIQGPPGTGK 18 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 16272700.0 6577200.0 3371200.0 6324300.0 False True 6368410.38617726 4717337.740575753 4667776.105066846 1.0 0.7407402247215117 0.7329578061109773 22.60250187678643 TVLQRPLSLIQGPPGTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVLQRPLSLIQGPPGTGK 18 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 14422800.0 3702000.0 4498100.0 6222700.0 False True 5070729.442788316 4299359.068772435 4753026.420529335 1.0 0.8478778284822635 0.9373456963453602 22.273761868386426 -10.215323031998963 4.718971892790631 1.00002128571061 0.8926117624133626 0.6576466240833111 0.03652510410809746 8.181162148804815e-06 1.3603863311776959e-06 0.0353722882381365 0.011788426660544377 6.090836869858896e-11 10.215323031998963 -0.10740952329724751 TVLQRPLSLIQGPPGTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVLQRPLSLIQGPPGTGK 18 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 11388000.0 6577200.0 2507700.0 2303100.0 False True 5469233.219364034 2494190.522360524 2784667.5616687615 1.0 0.45604025689190675 0.5091513654618964 22.382907152220707 -10.68140623838072 10.408762116319295 1.0002498407433873 0.4825958117911889 0.992159322989177 0.02168251927833892 0.0001257674744465313 3.849502142060177e-06 0.02100339308611721 0.0069980030057356585 2.0825419652272483e-11 10.68140623838072 -0.5176540289521985 TVLQRPLSLIQGPPGTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVLQRPLSLIQGPPGTGK 18 1 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 6988600.0 6988600.0 0.0 0.0 False True 9046880.465901136 0.0 0.0 1.0 0.0 0.0 23.10898897895429 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 TVLSHQGAVCEFCQPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVLSHQGAVCEFCQPR 16 0 P28340;M0R2B7;A0A087WYJ2;M0R3H8 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 1993050.0 555050.0 1438000.0 0.0 False True 727675.9251118465 1223456.005280097 0.0 1.0 1.6813198885095 0.0 19.47293655490237 -6.809820502733568 1.5024103930899497 1.3766880353778292 1.797227879410818e-20 0.8218375874597936 0.29145246517342344 0.21761786877373954 0.9819847615947083 0.15455229189363393 0.34397062156395525 1.5494568890985002e-07 6.809820502733568 -1.3766880353778292 TVMNSK(ub)THPPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVMNSKTHPPK 11 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 7864800.0 2387900.0 3029200.0 2447700.0 True False 2312097.4215703737 4238775.357069315 1806573.9405739927 1.0 1.8333030942054096 0.7813571883778885 21.140770757238606 -6.6955651112756565 1.8464554669396482 1.5196679181914645 0.7847081281503783 0.3966946460389642 0.35203917876146124 0.4048042965310694 2.6799079616913923 0.15227720356479768 0.39380842128953 2.0157417394350867e-07 6.6955651112756565 -0.7349597900410862 TVNCLLVGAIAIPHCVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVNCLLVGAIAIPHCVLK 18 0 Q5SY16 Q5SY16 NOL9 Polynucleotide 5-hydroxyl-kinase NOL9 0 19521000.0 3415200.0 10156000.0 5949800.0 False True 4477360.272843841 8640764.387777938 5334171.770511641 1.0 1.9298791835417048 1.1913653236404822 22.094216979353234 -10.277484921481172 5.138596692195425 0.999891368373249 1.5606222535912222 0.43450278929780495 0.30149702078899654 0.0003752920445364742 5.276871669461209e-05 0.2919793134039252 0.09730774503717944 5.2785553338198414e-11 10.277484921481172 0.5607308852179732 TVNCLLVGAIAIPHCVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVNCLLVGAIAIPHCVLK 18 0 Q5SY16 Q5SY16 NOL9 Polynucleotide 5-hydroxyl-kinase NOL9 0 41863000.0 19575000.0 11533000.0 10755000.0 False True 29696706.124191433 9474846.04225971 8629269.535916043 1.0 0.31905376989070655 0.29058002257315996 24.823799584401648 -13.40475978729711 0.4588947622217079 9.999590470797319 0.2908962956049857 0.9998989731262129 0.0032959740718120564 21.16942995040959 0.23157218016337558 189.87615001198049 0.006304185073569337 3.937678122229854e-14 13.40475978729711 -9.708694175192333 TVNCLLVGAIAIPHCVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVNCLLVGAIAIPHCVLK 18 0 Q5SY16 Q5SY16 NOL9 Polynucleotide 5-hydroxyl-kinase NOL9 0 23260500.0 3415200.0 5087300.0 14758000.0 False True 4677891.732309731 4862526.26454859 11272464.350550719 1.0 1.039469603574535 2.409731775682822 22.157427040876126 -6.913059481964796 0.8746334055121294 0.9615680068025798 2.598916984674701 0.9920259746734448 0.05852988572196677 0.10242971609306373 0.12804757989600446 0.04865617223047421 0.13733972655585197 1.2216323311502089e-07 6.913059481964796 1.637348977872121 up TVNDIVSALLNAEDEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVNDIVSALLNAEDEKR 17 1 E9PMH5;Q13490-2;Q13490;A0A087X2B2;E9PIW1 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 10835400.0 4080500.0 3552500.0 3202400.0 True False 5349575.015618216 3022480.847536544 2871046.3675899142 1.0 0.5649945722253331 0.5366868132903686 22.350992853882172 -13.999999999999956 0.3883502995573896 7.805867378857189 0.5345551527360393 0.9998206307443436 0.0028399662144732323 25.125644402889055 0.20409086224224654 143.44827966257176 0.0074859096540473855 1.0000000000001022e-14 13.999999999999956 -7.27131222612115 TVNDIVSALLNAEDEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVNDIVSALLNAEDEKR 17 1 E9PMH5;Q13490-2;Q13490;A0A087X2B2;E9PIW1 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 93740500.0 21558000.0 17947000.0 54235500.0 True False 20873653.090252597 25113330.69236861 40029595.519876115 1.0 1.203111433527456 1.9177091497495855 24.315179772327312 -6.947824656921703 0.5822350224135284 0.991527706945254 2.164774057125167 0.9990193380641641 0.012324928895625212 0.0843711686175048 0.039669235311788405 0.01288229221900823 0.05973125884246584 1.1276526454180829e-07 6.947824656921703 1.1732463501799129 TVNDIVSALLNAEDEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVNDIVSALLNAEDEKR 17 1 E9PMH5;Q13490-2;Q13490;A0A087X2B2;E9PIW1 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 116567100.0 15847000.0 55317100.0 45403000.0 True False 24041057.57088441 45445331.310525045 36429077.14915818 1.0 1.8903216373294192 1.5152859661746587 24.51899702609719 -10.227603510130747 4.8125872723582965 0.9998652252342233 1.7028038017536247 0.8240157749357466 0.1531076716173599 0.0002214464153565615 3.5540618632944014e-05 0.14827395354130352 0.04941528852844257 5.921019479554988e-11 10.227603510130747 0.7029385765194014 TVNDIVSALLNAEDEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVNDIVSALLNAEDEKR 17 1 E9PMH5;Q13490-2;Q13490;A0A087X2B2;E9PIW1 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 15836500.0 4080500.0 3414200.0 8341800.0 True False 5589171.121366215 3263349.354750416 6371638.644763785 1.0 0.5838700021681791 1.1399970597440403 22.414202915405063 -6.706418638028771 1.807891636095361 0.7432440271571463 1.1385623834947034 0.4481252006997807 0.17545609964900494 0.38231469294700365 2.4335329380829442 0.07729663125086023 0.19723314661342198 1.9659902603242068e-07 6.706418638028771 0.3953183563375571 TVNDIVSALLNAEDEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVNDIVSALLNAEDEKR 17 1 E9PMH5;Q13490-2;Q13490;A0A087X2B2;E9PIW1 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 68782000.0 21558000.0 18518000.0 28706000.0 True False 17926432.181330938 18418239.858464807 34708291.87845225 1.0 1.0274347774369765 1.9361516852527065 24.09558504776159 -6.9133459940871465 0.8726487188216816 0.974753003741344 2.062393422039316 0.9921238509838101 0.038603808800217035 0.10224696244007536 0.127076919728944 0.032137813571067264 0.0909116708045048 1.220826663436166e-07 6.9133459940871465 1.0876404182979722 TVNDIVSALLNAEDEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVNDIVSALLNAEDEKR 17 1 E9PMH5;Q13490-2;Q13490;A0A087X2B2;E9PIW1 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 86288100.0 15847000.0 31702000.0 38739100.0 True False 20514253.891070537 29937755.831702318 31688981.296732694 1.0 1.459363620566949 1.5447298968317 24.29012334818964 -11.86875668998503 0.27834273736823395 1.1117418183278672e-14 1.5735853184446242 0.9994004259481309 0.005857569854022533 4.831210409661633 0.1553501547558641 2.8453572293992138 0.03398431745352698 1.352830263277297e-12 11.86875668998503 1.5735853184446131 TVNDIVSALLNAEDEK(ub)REEEKEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVNDIVSALLNAEDEKREEEKEK 23 3 E9PMH5;Q13490-2;Q13490;A0A087X2B2;E9PIW1 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 19539400.0 2590500.0 4408900.0 12540000.0 True False 3548277.855630232 4214100.219717383 9578310.269406835 1.0 1.1876466249762987 2.6994250898949317 21.75868755676593 -6.929965147255966 0.7470807961809461 0.9769810512769485 3.009507554134898 0.9965313711526542 0.044804705074953786 0.09265583171803712 0.07776946391663503 0.04081084115455694 0.13681598301566122 1.1749918459070241e-07 6.929965147255966 2.03252650285795 up TVNDIVSALLNAEDEKREEEK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVNDIVSALLNAEDEKREEEK 21 2 E9PMH5;Q13490-2;Q13490;A0A087X2B2;E9PIW1 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 97716000.0 13618000.0 41016000.0 43082000.0 True False 20659501.609156538 33696374.34052932 34566823.81648857 1.0 1.631035200074463 1.6731683305064893 24.300302115187446 -11.379460525812059 0.45306041063589436 3.013749843775701e-19 1.6732684673016562 0.9997628503445262 0.004741315593878738 3.720927642008255 0.22340149560608802 3.7005717762877652 0.009435624539733574 4.173875342114608e-12 11.379460525812059 1.6732684673016562 TVNDIVSALLNAEDEKREEEK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVNDIVSALLNAEDEKREEEK 21 2 E9PMH5;Q13490-2;Q13490;A0A087X2B2;E9PIW1 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 75418000.0 13618000.0 27585000.0 34215000.0 True False 17628769.45091174 26049870.50083616 27988221.075546686 1.0 1.4776908038518188 1.5876446256490786 24.071428437279895 -11.788899281999154 0.2481756626896923 1.9759699043970995e-09 1.6379080377310422 0.9993485779852116 0.006510465062952779 4.640392701337376 0.14269412936585943 2.4731972671278086 0.05110579754824278 1.6259257833522146e-12 11.788899281999154 1.6379080357550724 TVNDIVSALLNAEDEKREEEKEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVNDIVSALLNAEDEKREEEKEK 23 3 E9PMH5;Q13490-2;Q13490;A0A087X2B2;E9PIW1 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 171067000.0 73594000.0 18466000.0 79007000.0 True False 71257798.75331886 25839570.09891783 58312696.54080545 1.0 0.36262094186167015 0.8183342393535489 26.086544581632772 -9.7898211825837 6.037630751002342 1.0000000202145838 0.5904775906069915 0.5184759753321768 0.18604417464532103 5.0724625523706305e-08 9.780881809396701e-09 0.1801365082508677 0.06004549917130332 1.6224780026993913e-10 9.7898211825837 -0.40952242960759233 TVNDIVSALLNAEDEKREEEKEK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVNDIVSALLNAEDEKREEEKEK 23 3 E9PMH5;Q13490-2;Q13490;A0A087X2B2;E9PIW1 E9PMH5 BIRC2 Baculoviral IAP repeat-containing protein 2 1 124806000.0 73594000.0 28025000.0 23187000.0 True False 61196671.76699451 27874023.76247307 28035294.495425113 1.0 0.4554826750808121 0.45811796109058206 25.86694985706705 -10.134862653885497 7.779282792337614 1.0000001011140336 0.4568003180857067 0.9999823476470258 0.001075851008371928 1.8869087151509565e-09 2.0951146266601531e-10 0.0010416884613935384 0.000347229419868746 7.330563263657224e-11 10.134862653885497 -0.5431997830283268 TVNELQNLSSAEVVVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVNELQNLSSAEVVVPR 17 0 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 0 8396200.0 1300600.0 3167100.0 3928500.0 False True 1705099.195028317 2694581.0252591097 3522016.5048329337 1.0 1.5803074877496264 2.065578656715302 20.701424240545855 -6.9731858906914015 0.1652143573213595 0.5425912851330847 3.116232214160337 0.9999977660899907 0.0006510294661697132 0.07528182811101289 0.005127426584038854 0.021379074202656778 0.05715150858200357 1.0636876314751159e-07 6.9731858906914015 2.5736409290272526 TVNELQNLSSAEVVVPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVNELQNLSSAEVVVPR 17 0 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 0 7311200.0 1874000.0 1340500.0 4096700.0 False True 1814510.8957757372 1875768.6406151506 3023651.371634381 1.0 1.033759921189795 1.6663726730291766 20.791149289263178 -6.917934348007669 0.8398894680098524 0.9849765884236823 1.763697983472632 0.9935881351864184 0.024541424320813146 0.09940200353116908 0.11201884570807673 0.02091701567707521 0.06147223377318116 1.2079964332786668e-07 6.917934348007669 0.7787213950489498 TVNELQNLSSAEVVVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVNELQNLSSAEVVVPR 17 0 O00425;O00425-2 O00425 IGF2BP3 Insulin-like growth factor 2 mRNA-binding protein 3 0 6353200.0 1300600.0 2331600.0 2721000.0 False True 1781466.9673934306 2228582.2024298706 2078355.8407540645 1.0 1.2509814906591508 1.1666541557012586 20.764634302068746 -10.07654192274736 4.318094777283021 0.9999790737245935 1.2088178230863205 0.8910192063934479 0.03442649042950955 18072865.962606072 0.040463297544468056 3861.196504067326 0.012598805430775704 8.384131421137051e-11 10.07654192274736 0.20883874936172697 TVNLTDFSNK(ub)WDSTNPFPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVNLTDFSNKWDSTNPFPK 19 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 19316700.0 3572900.0 4832800.0 10911000.0 True False 3459480.2452065805 6762562.242719056 8053081.77701632 1.0 1.9547914031563531 2.3278299646817135 21.722123871929252 -10.103320179715054 0.22309737038211694 2.804049632326158e-18 2.5916280296061482 0.9992632300515834 0.015177501774327324 1.6239236456089559 0.10394103345139567 1.1721495622750313 0.1948048914442949 7.88278751895513e-11 10.103320179715054 2.5916280296061482 TVNLTDFSNK(ub)WDSTNPFPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVNLTDFSNKWDSTNPFPK 19 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 139207800.0 5704400.0 14214000.0 119289400.0 True False 8653991.847501287 11677400.645511117 95711797.80359861 1.0 1.3493658015038221 11.059843768079581 23.044934330992806 -6.914521298537411 0.864374176040487 0.740608606528113 12.444151832470073 0.992518942101333 0.4032388097771365 0.1015036217240923 0.1231099119582778 0.337702811086613 0.96417714397851 1.217527281779804e-07 6.914521298537411 11.70354322594196 up TVNLTDFSNK(ub)WDSTNPFPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVNLTDFSNKWDSTNPFPK 19 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 22802300.0 3572900.0 6363400.0 12866000.0 True False 2971024.6563075087 6329119.101163995 15556221.114337297 1.0 2.13028158070894 5.23597846329256 21.50252914736353 -6.953407100823745 0.5200975599030546 0.9472658449350183 6.557613596590874 0.9994422415049041 0.042295890610760827 0.08214581042844861 0.030518600261491214 0.0479083928204922 0.256534611597697 1.1132505008100352e-07 6.953407100823745 5.610347751655856 TVNLTDFSNK(ub)WDSTNPFPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVNLTDFSNKWDSTNPFPK 19 1 A0A0D9SFD2;Q8N1K5-2;Q8N1K5;Q8N1K5-4;Q8N1K5-3 A0A0D9SFD2 THEMIS Protein THEMIS 1 110832000.0 5704400.0 13712000.0 91415600.0 True False 7384458.250534654 12948915.146183277 74778898.80326596 1.0 1.7535362387952755 10.126524690941515 22.816060653085255 -6.924534608340254 0.7903727904993778 0.8436603013860455 11.62836225457579 0.9953505342434269 0.2820303172021347 0.09557664391650508 0.0923243206036036 0.24902859099156185 0.7816100160711833 1.1897765137000027e-07 6.924534608340254 10.784701953189746 up TVNQK(ub)TTIYEIQDDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVNQKTTIYEIQDDR 15 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 13862300.0 4977300.0 4636300.0 4248700.0 True False 6525288.500241761 3944582.112155855 3809085.2804082185 1.0 0.6045069290054699 0.5837420491472665 22.63761025777557 -13.999999999999998 0.4200897367248052 8.591135704506677 0.5830711479361289 0.9998642500643994 0.0022314173734713253 29.976726199249267 0.21618126196158072 208.89809967007292 0.005037410434096152 1.0000000000000041e-14 13.999999999999998 -8.008064556570547 TVNQK(ub)TTIYEIQDDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVNQKTTIYEIQDDR 15 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 58250400.0 7504100.0 5184300.0 45562000.0 True False 7265886.453036669 7254418.02576735 33627945.36929862 1.0 0.9984216065935732 4.628195828087064 22.79270738967145 -6.906793464348228 0.9172675390865741 0.8759027652015489 5.06652044047114 0.9896548683762207 0.17399908323737348 0.10657757472236501 0.15054126167583018 0.14023434237748578 0.37903935887832707 1.239385856067139e-07 6.906793464348228 4.190617675269591 up TVNQK(ub)TTIYEIQDDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVNQKTTIYEIQDDR 15 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 222810700.0 7708700.0 17482000.0 197620000.0 True False 11694661.481458738 14362200.51251056 158560320.38007706 1.0 1.2280988667590818 13.5583505885541 23.479346765654842 -6.910906166466885 0.8895182192153431 0.6290875106096918 15.183232141091018 0.9912596389627824 0.5485088659547454 0.10382225405371787 0.1355307390273719 0.45109378117851656 1.2532188716522121 1.2277044599553924e-07 6.910906166466885 14.554144630481327 up TVNQK(ub)TTIYEIQDDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVNQKTTIYEIQDDR 15 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 16034700.0 4977300.0 4805800.0 6251600.0 True False 6817542.316474945 4593463.865344605 4775100.83574352 1.0 0.6737712290020205 0.7004138168976585 22.70082031929846 -9.925216794339306 5.142837954289946 1.0000009289237641 0.6870925229452348 0.9945921164380788 0.010876790977969591 1.1584980276390303e-07 2.419799914008278e-08 0.010531438800397485 0.00351046919084947 1.1879090901393056e-10 9.925216794339306 -0.3129084059785293 TVNQK(ub)TTIYEIQDDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVNQKTTIYEIQDDR 15 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 657008700.0 7708700.0 12112000.0 637188000.0 True False 9979064.111194259 11437956.552696317 521226322.1009915 1.0 1.1461953170403536 52.23198451208397 23.25047308774729 -6.90357611105135 0.9396136475971725 7.489612030500463e-16 57.9753013010426 0.989959696184612 2.416515508299375 0.1036603550411184 0.15575786636266714 1.9606744304525885 5.191828263321149 1.2486016052713244e-07 6.90357611105135 57.9753013010426 up TVNVPFHLALSDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVNVPFHLALSDK 13 0 Q9H2M9 Q9H2M9 RAB3GAP2 Rab3 GTPase-activating protein non-catalytic subunit 0 5480800.0 1879900.0 1954900.0 1646000.0 False True 2464567.1049774946 1663236.5401405164 1475687.709546901 1.0 0.6748595064753591 0.5987614240921131 21.232902832419033 -13.999999999999998 0.20401908011038924 2.835717672296604 0.5512519007175479 0.9994875410962748 0.003939043508203373 12.613302790314114 0.1432030158784779 9.255784742455052 0.04704260128109525 1.0000000000000041e-14 13.999999999999998 -2.284465771579056 TVNVPFHLALSDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVNVPFHLALSDK 13 0 Q9H2M9 Q9H2M9 RAB3GAP2 Rab3 GTPase-activating protein non-catalytic subunit 0 5391300.0 1879900.0 1088600.0 2422800.0 False True 2574949.8323872876 1040502.0524811974 1850584.539132285 1.0 0.4040863396225965 0.7186876093102641 21.296112893941924 -10.58385515732649 6.5924757316038365 1.0007918752123015 0.5613869744664624 0.7215785127712513 0.12843543052775103 0.0014973123900504986 9.451672010801238e-05 0.12456353792252492 0.041452356958079944 2.60702287995364e-11 10.58385515732649 -0.43940490074583916 TVNVVQFEPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVNVVQFEPSK 11 0 P41250 P41250 GARS Glycine--tRNA ligase 0 7407190.0 949690.0 2613700.0 3843800.0 False True 1245052.7868110414 2223746.148122803 3446080.448333161 1.0 1.7860657569535607 2.767818750207066 20.247775479212795 -6.968122098257827 0.2996660002611317 0.829053932161236 3.755578405280429 0.9999638060645405 0.004350756142433791 0.07691688317419926 0.011199582504152553 0.016314624550852537 0.08808023681472173 1.0761626169850597e-07 6.968122098257827 2.9265244731191933 TVNVVQFEPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVNVVQFEPSK 11 0 P41250 P41250 GARS Glycine--tRNA ligase 0 7125800.0 2634300.0 1969000.0 2522500.0 False True 2550675.588442919 2755231.9681993513 1861781.576622093 1.0 1.080196941031339 0.7299170404334457 21.282447988567693 -6.846498835154602 1.2519606538307306 1.0426987111438148 0.7168390352389112 0.9350399859724834 0.03819049222146116 0.16135183942679984 0.48845329970694384 0.02389050506608939 0.05517139034766786 1.42397106595316e-07 6.846498835154602 -0.3258596759049036 TVNVVQFEPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVNVVQFEPSK 11 0 P41250 P41250 GARS Glycine--tRNA ligase 0 8494990.0 949690.0 3100500.0 4444800.0 False True 1300816.0574072467 2963509.6580175958 3395029.7835294614 1.0 2.278192709217003 2.609923028084653 20.310985540735686 -10.240273749616392 0.3057374709335201 4.453427237797784e-11 2.7146608610097114 0.998978614029442 0.022182064963623356 1.701922608109751 0.14249976179913698 1.5170720637140584 0.11569656569812878 5.750773335461202e-11 10.240273749616392 2.7146608609651772 TVNVVQFEPSK(ub)GAIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVNVVQFEPSKGAIGK 16 1 P41250 P41250 GARS Glycine--tRNA ligase 1 7054900.0 1731700.0 2869900.0 2453300.0 True False 1676728.1313846544 4015866.0363307865 1810707.1325775934 1.0 2.3950609291766667 1.0799050237692966 20.677217355245258 -6.632321218189401 2.072570005757306 1.917547263408491 1.0852939854956127 0.1257741462873142 0.5980605165778445 0.5529386590742679 4.529549129357631 0.23579663133716383 0.6622297550329629 2.3317327996354913e-07 6.632321218189401 -0.8322532779128782 TVNVVQFEPSK(ub)GAIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVNVVQFEPSKGAIGK 16 1 P41250 P41250 GARS Glycine--tRNA ligase 1 5851200.0 1731700.0 3045700.0 1073800.0 True False 1439985.277317504 3029292.2095758864 1298326.6153097628 1.0 2.1036966539123543 0.9016249233661389 20.457622630679534 -6.665305734407226 1.95434859250686 1.7073306644686468 0.9066099910638341 0.25824881195926275 0.4693438535375578 0.4720095841838276 3.4711001244885042 0.19366703671073357 0.5205545922667902 2.1611965500289203e-07 6.665305734407226 -0.8007206734048127 TVNVVQFEPSK(ub)GAIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVNVVQFEPSKGAIGK 16 1 P41250 P41250 GARS Glycine--tRNA ligase 1 11508100.0 2124100.0 2642300.0 6741700.0 True False 2749689.322270641 2495253.682231625 5514779.775683555 1.0 0.9074674953354701 2.0056010440952488 21.390837192128917 -6.886431457029981 1.0432968930273192 0.9358497921194201 2.0936907418081008 0.9785128432125587 0.07289552225626313 0.12208480607667889 0.23916150934640307 0.05347259717286049 0.13170132936179807 1.29887854448553e-07 6.886431457029981 1.1578409496886808 up TVPEELVKPEELSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVPEELVKPEELSK 14 1 Q9UMS4;F5GY56;H0YGF3 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 8889000.0 2450100.0 1948300.0 4490600.0 False True 2372322.9166169334 2726266.3502502805 3314377.144887677 1.0 1.1491969879623682 1.3971020225248956 21.177868969804084 -6.963501632849796 0.38290400306465755 0.9835176498539558 1.5715883882292774 0.999878838657665 0.0018027403663264329 0.07847323042597983 0.016676355034953624 0.0032172587498536173 0.020919084423810453 1.0876730482167262e-07 6.963501632849796 0.5880707383753215 TVPFCSTFAAFFTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVPFCSTFAAFFTR 14 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 186945000.0 73588000.0 79953000.0 33404000.0 False True 96474580.62720582 68024324.054353 29947674.5137939 1.0 0.7051010080801549 0.31042036481627017 26.52364553162937 -7.079806727972693 0.33987556887764037 1.0463438936186304 2.6657094871849843e-11 0.9999268475964262 0.002416195838515947 0.07459868554071357 0.014501629207911875 0.006287094731574724 0.03358067258684668 8.321340093918505e-08 7.079806727972693 -1.0463438935919733 down TVPFCSTFAAFFTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVPFCSTFAAFFTR 14 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 584808000.0 345520000.0 152150000.0 87138000.0 False True 334551656.728086 212904288.45176795 64313943.716034 1.0 0.6363868902458027 0.19223920259437405 28.317653747698376 -7.466657757172729 0.40665388462923907 1.0347262251749587 8.561732930230113e-20 0.9989477246503206 0.010714948680557767 0.11705206974972163 0.04657699977653108 0.017982169813683307 0.06445276355785172 3.41461892357131e-08 7.466657757172729 -1.0347262251749587 down TVPFCSTFAAFFTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVPFCSTFAAFFTR 14 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 1018870000.0 325830000.0 281680000.0 411360000.0 False True 494307931.3637441 231412003.22411463 330054515.6945073 1.0 0.46815353050409897 0.6677103375297282 28.880834814367482 -10.121724680108825 5.214787054808003 1.0000113640569162 0.5679319340164789 0.8620771686428869 0.0814687253201612 1.0764018629686471e-05 1.813013330516832e-06 0.07888382725679967 0.026293918033258572 7.555710682420856e-11 10.121724680108825 -0.43207943004043725 TVPFCSTFAAFFTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVPFCSTFAAFFTR 14 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 394597000.0 73588000.0 73999000.0 247010000.0 False True 100795472.24092564 70729479.49803051 188671325.33063647 1.0 0.7017128639366845 1.8718234176200517 26.58685559315226 -6.839102529288438 1.2866126974244985 0.8413010104272741 1.9096190479207005 0.9228989886951887 0.13785106037386957 0.16984245694414335 0.5465383774571031 0.08402825030589531 0.19353473905957488 1.448429864362769e-07 6.839102529288438 1.0683180374934262 TVPFCSTFAAFFTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVPFCSTFAAFFTR 14 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 690916000.0 345520000.0 78156000.0 267240000.0 False True 287315189.13134176 77734958.11524872 323118648.4218483 1.0 0.2705563821748156 1.1246138757883055 28.098059023132652 -6.680564555502275 1.900267724842159 0.5386982497164864 1.1213480979287043 0.3265719758607116 0.3091185203134789 0.43725051280887856 3.0532795454154686 0.13051752083744786 0.3439337463893654 2.0865819418543772e-07 6.680564555502275 0.5826498482122179 TVPFCSTFAAFFTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVPFCSTFAAFFTR 14 0 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 890950000.0 325830000.0 270050000.0 295070000.0 False True 421793358.06950843 255021480.10697165 241370287.6738728 1.0 0.6046123658138448 0.5722477204918356 28.65196113645993 -13.999999999999998 0.3546556242294032 6.004370787352205 0.5680479914089572 0.9997634776141602 0.0029907319521110046 21.13248632315475 0.19205188925182548 79.84732451788445 0.009505878519169543 1.0000000000000041e-14 13.999999999999998 -5.436322795943248 TVPLAGHVGFDSLPDQLVNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVPLAGHVGFDSLPDQLVNK 20 0 Q14141;B1AMS2;Q14141-2;Q14141-4;Q14141-3 Q14141 SEPT6 Septin-6 0 27295200.0 6116200.0 10798000.0 10381000.0 False True 8018397.429365061 9186980.490274342 9306873.70158348 1.0 1.1457377326583593 1.160689998664789 22.93488249531428 -13.391611845361359 0.32897952957652754 6.064822076789795e-19 1.1634205443457293 0.9996869589040407 0.0012824299594641115 12.581260641133003 0.1819889829720678 8.559435603741353 0.004812131798091521 4.058711243953151e-14 13.391611845361359 1.1634205443457293 TVPLAGHVGFDSLPDQLVNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVPLAGHVGFDSLPDQLVNK 20 0 Q14141;B1AMS2;Q14141-2;Q14141-4;Q14141-3 Q14141 SEPT6 Septin-6 0 26305900.0 9251900.0 4765000.0 12289000.0 False True 8958203.498734029 6667689.349146735 9070142.237902435 1.0 0.7443109938381073 1.0124956682647615 23.0947780088243 -11.059384481326713 11.355896501977771 1.5744942803760904 0.8784033310452214 0.2151342498940675 0.10948593486328925 0.041713438648342226 0.00021813640544532075 0.0027768586310026222 0.035336433530789094 8.721988679857846e-12 11.059384481326713 -0.696090949330869 TVPLAGHVGFDSLPDQLVNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVPLAGHVGFDSLPDQLVNK 20 0 Q14141;B1AMS2;Q14141-2;Q14141-4;Q14141-3 Q14141 SEPT6 Septin-6 0 22508600.0 6116200.0 7233400.0 9159000.0 False True 8377524.4240901945 6913804.470344937 6995832.835526089 1.0 0.8252801329308905 0.8350716132093929 22.99809255683717 -10.01029142132433 6.780466902094049 1.000000033060782 0.8301758730709117 0.9975129835809137 0.003997355084810869 1.9963429826166847e-09 2.934527170465111e-10 0.0038704231390082285 0.0012901408060289354 9.765816928548033e-11 10.01029142132433 -0.16982415998987022 TVPLAGHVGFDSLPDQLVNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVPLAGHVGFDSLPDQLVNK 20 0 Q14141;B1AMS2;Q14141-2;Q14141-4;Q14141-3 Q14141 SEPT6 Septin-6 0 18609600.0 9251900.0 4867200.0 4490500.0 False True 7693364.778664805 4840979.42753644 5429442.788273879 1.0 0.6292408545297913 0.7057305801137597 22.875183284258576 -10.095954026362921 5.200964544505921 1.0000066053989851 0.6674857173212901 0.9618280527945057 0.03122679970941026 2.391769288554192e-06 4.1573571313993133e-07 0.030235819190097678 0.010078406268912949 8.017629320855391e-11 10.095954026362921 -0.332520888077695 TVPPAVTGITFLSGGQSEEEASINLNAINK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVPPAVTGITFLSGGQSEEEASINLNAINK 30 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 77064500.0 8189500.0 57347000.0 11528000.0 False True 12424070.232647058 47112979.79584391 9249485.74709811 1.0 3.7920728805962387 0.7444811220394579 23.566634554555282 -6.665728311797199 1.9524663603518524 2.7886505077411217 0.7569832117690727 0.26031330250562035 1.1871872349357369 0.47098354730042963 3.4571899290706796 0.4902293449068897 1.3171329198296955 2.1590946844448253e-07 6.665728311797199 -2.031667295972049 TVPQYK(ub)YAAGVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVPQYKYAAGVR 12 1 P11940;E7EQV3;E7ERJ7;H0YAS6;H0YB75;H0YAS7;H0YAW6 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 14046500.0 5665700.0 5858600.0 2522200.0 True False 7427787.566716843 4984519.716643941 2261226.938650788 1.0 0.6710638493458084 0.3044280572566607 22.824501124389286 -7.258896363685366 0.30931142666013545 1.0691384081570625 7.247701828465416e-14 0.9998726873840798 0.0032056342705952577 0.09838797560542491 0.019707266779873066 0.011541035525887582 0.045519112289867845 5.509391521195057e-08 7.258896363685366 -1.0691384081569901 down TVPQYK(ub)YAAGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVPQYKYAAGVR 12 1 P11940;E7EQV3;E7ERJ7;H0YAS6;H0YB75;H0YAS7;H0YAW6 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 15917900.0 7117400.0 8800500.0 0.0 True False 6891462.032867795 12314585.544001218 0.0 1.0 1.786933670281959 0.0 22.71637865440326 -6.797158190316286 1.534393899194016 1.4409773272332533 7.891732829281388e-19 0.7910408786678477 0.33426439185765194 0.233400216159424 1.0957081203366972 0.17317538777272032 0.39208503165264946 1.5952979594352726e-07 6.797158190316286 -1.4409773272332533 TVPQYK(ub)YAAGVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVPQYKYAAGVR 12 1 P11940;E7EQV3;E7ERJ7;H0YAS6;H0YB75;H0YAS7;H0YAW6 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 42362600.0 12148300.0 15160300.0 15054000.0 True False 18429859.25969426 12454826.017035456 12078570.301597416 1.0 0.6757960460541289 0.6553804959331954 24.135541718027888 -13.999999999999998 0.39319586385126637 6.231747568081069 0.6539866589778868 0.9998279206932373 0.0020708279329589726 25.79209164599886 0.20589234668818737 114.82526908723035 0.0053244695504629245 1.0000000000000041e-14 13.999999999999998 -5.577760909103182 TVPQYK(ub)YAAGVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVPQYKYAAGVR 12 1 P11940;E7EQV3;E7ERJ7;H0YAS6;H0YB75;H0YAS7;H0YAW6 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 12726480.0 5665700.0 4110480.0 2950300.0 True False 7760462.399785446 3928865.402060365 2253499.9033357995 1.0 0.5062669206629989 0.2903821689024744 22.887711185912178 -11.726633011536594 0.1435409117532362 2.2707220113179667 3.1005376336447647e-19 0.9996511097472796 0.005547734750905809 4.762424761771737 0.0944224567713928 2.0774159531569647 0.21942222132725053 1.8765795896064488e-12 11.726633011536594 -2.2707220113179667 TVPQYK(ub)YAAGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVPQYKYAAGVR 12 1 P11940;E7EQV3;E7ERJ7;H0YAS6;H0YB75;H0YAS7;H0YAW6 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 21163600.0 7117400.0 10554100.0 3492100.0 True False 5918433.454281701 10497242.968475174 4222281.964353904 1.0 1.7736522763267577 0.7134120873318744 22.496783929837537 -6.711082955661587 1.7914411731643394 1.4751068461491978 0.7158364761593374 0.4701593939258851 0.32595936834886907 0.3729247815975368 2.3336686713642263 0.1447635746984532 0.367272058570873 1.944988529075632e-07 6.711082955661587 -0.7592703699898604 TVPQYK(ub)YAAGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVPQYKYAAGVR 12 1 P11940;E7EQV3;E7ERJ7;H0YAS6;H0YB75;H0YAS7;H0YAW6 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 35408400.0 12148300.0 21922500.0 1337600.0 True False 15726213.828793593 20702493.603573717 1094170.5249350062 1.0 1.3164321577307379 0.06957622075134555 23.906668040120337 -6.839433860089321 1.2850603954791324 1.168351969192885 0.029038928562376224 0.9234594549787576 0.1464080871423121 0.1694715995307033 0.5438859443931331 0.0893447996487253 0.20579849695785876 1.447325253487199e-07 6.839433860089321 -1.1393130406305088 down TVQIPVYDFVSHSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVQIPVYDFVSHSR 14 0 Q9BZX2;A0A2R8Y653 Q9BZX2 UCK2 Uridine-cytidine kinase 2 0 6141000.0 3081400.0 3059600.0 0.0 False True 4039745.24032005 2603119.606227393 0.0 1.0 0.644377170185405 0.0 21.94583288405476 -7.54687773129504 0.6970345064186546 0.9946015425566106 9.724147170065739e-15 0.9870615583846623 0.04707802003710191 0.12045088198871358 0.14427907939496276 0.04202040542980346 0.07638897995265607 2.8387181118930092e-08 7.54687773129504 -0.9946015425566008 down TVQK(ub)QGFHHLWLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVQKQGFHHLWLQR 14 1 Q969X6;H3BSH7;Q969X6-3;Q969X6-2;A0A0J9YWM9;A0A0J9YWK2;A0A0J9YXV4 Q969X6 CIRH1A Cirhin 1 18401200.0 6875400.0 4464400.0 7061400.0 True False 6657144.1904036915 6247058.2015384445 5211807.502540836 1.0 0.9383991127221808 0.782889382214927 22.666471985969544 -6.955252564690858 0.4978534491384173 1.0031731668119082 0.7114325060540723 0.9995516052033866 0.0019345071153678986 0.08144265204809056 0.027745440676060117 0.0022779415197051013 0.012827312904784016 1.1085299602980762e-07 6.955252564690858 -0.2917406607578359 TVQK(ub)QGFHHLWLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVQKQGFHHLWLQR 14 1 Q969X6;H3BSH7;Q969X6-3;Q969X6-2;A0A0J9YWM9;A0A0J9YWK2;A0A0J9YXV4 Q969X6 CIRH1A Cirhin 1 23084500.0 6875400.0 10638000.0 5571100.0 True False 5717199.731863939 10580690.982522331 6735991.252143989 1.0 1.8506771634288839 1.1781976436124788 22.44687726140382 -10.232356047133917 4.773852362252266 0.9998886528784662 1.5144374035219006 0.43828789127727175 0.2745386143416351 0.00032544759988525185 5.233247698188617e-05 0.265878000965187 0.08860695676901068 5.856578284760902e-11 10.232356047133917 0.5145487506434344 TVQTAAANAASTAASSAAQNAFK(ub)GNQI ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVQTAAANAASTAASSAAQNAFKGNQI 27 1 A0A087WXB0;O15126;A0A087WU14 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 21208700.0 7232700.0 10847600.0 3128400.0 True False 9482139.74156644 9229180.363613613 2804703.1777317896 1.0 0.973322542712175 0.29578800293745255 23.176781224039964 -6.915204055760801 0.8595519811271335 1.0176856713742888 0.19773748387213588 0.9927414224672153 0.02776262840659483 0.10107653656005915 0.12084814964294784 0.023331485442127094 0.066981712307238 1.2156147028815746e-07 6.915204055760801 -0.8199481875021529 down TVQTAAANAASTAASSAAQNAFK(ub)GNQI ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVQTAAANAASTAASSAAQNAFKGNQI 27 1 A0A087WXB0;O15126;A0A087WU14 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 43004100.0 20325800.0 14670700.0 8007600.0 True False 19680568.604780424 20528787.016689803 5910169.33714928 1.0 1.043099283813545 0.3003048060163107 24.230268567380893 -6.893134921444526 1.0036358809623942 1.0369636863416682 0.23234699599705125 0.9828307199334729 0.04461010809113175 0.11663710220740373 0.20727660080942345 0.03371986115556297 0.08507207287401679 1.2789839029229117e-07 6.893134921444526 -0.804616690344617 down TVQTAAANAASTAASSAAQNAFK(ub)GNQI ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVQTAAANAASTAASSAAQNAFKGNQI 27 1 A0A087WXB0;O15126;A0A087WU14 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 67833000.0 41163000.0 13931000.0 12739000.0 True False 62447280.41839552 11444904.206600208 10221131.066297958 1.0 0.18327306057076595 0.16367616007961572 25.896135407985078 TVQTAAANAASTAASSAAQNAFK(ub)GNQI ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVQTAAANAASTAASSAAQNAFKGNQI 27 1 A0A087WXB0;O15126;A0A087WU14 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 26100300.0 7232700.0 12172000.0 6695600.0 True False 9906824.64636819 11634200.792578656 5114237.18021055 1.0 1.1743622409672625 0.5162337441881959 23.239991285562855 -6.8362419201011075 1.2996381521935751 1.0928495333750636 0.4961361376502849 0.9178153682638321 0.07981167454848817 0.17323231774155542 0.569978221396544 0.048180599048007235 0.11091769812493635 1.4580018663083372e-07 6.8362419201011075 -0.5967133957247788 TVQTAAANAASTAASSAAQNAFK(ub)GNQI ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVQTAAANAASTAASSAAQNAFKGNQI 27 1 A0A087WXB0;O15126;A0A087WU14 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 44086100.0 20325800.0 13039000.0 10721300.0 True False 16901803.28561539 12968756.318961153 12963074.260309689 1.0 0.7673001572559105 0.7669639766392363 24.01067384281517 TVQTAAANAASTAASSAAQNAFK(ub)GNQI ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVQTAAANAASTAASSAAQNAFKGNQI 27 1 A0A087WXB0;O15126;A0A087WU14 A0A087WXB0 SCAMP1 Secretory carrier-associated membrane protein 1 1 63783200.0 41163000.0 15974000.0 6646200.0 True False 53286314.94403581 15085032.857725456 5436659.79577081 1.0 0.2830939402277785 0.10202731792357354 25.667261730077527 -12.705376216554379 0.2158538683965792 3.3334511780454092 8.433127703040027e-18 0.9994047013687863 0.009460414128841998 7.403056112420926 0.14115688690855435 7.531040349984188 0.10221833437416428 1.9707148240927238e-13 12.705376216554379 -3.3334511780454092 TVQTAVFLYSLYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVQTAVFLYSLYK 13 0 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y8B3 A0A2R8YFD8 CHD4 Chromodomain-helicase-DNA-binding protein 4 0 9893500.0 1299500.0 2521200.0 6072800.0 False True 1779960.267667049 2409805.0475065173 4638529.713241924 1.0 1.3538532804808001 2.605973738572003 20.763413606988053 -6.947692791567832 0.5836232275915877 0.9852271823982551 3.0369184824233253 0.9990075700374202 0.02170465554891152 0.0844256317023773 0.03989999781585944 0.02265264261813486 0.10470207669978082 1.1279950879273418e-07 6.947692791567832 2.05169130002507 up TVQVVPHITDAIQEWVMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVQVVPHITDAIQEWVMR 18 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8 A0A3B3IRI2 CTPS1 CTP synthase 1 0 17981400.0 6877100.0 3916000.0 7188300.0 False True 6658790.224834219 5479679.221670221 5305468.585622433 1.0 0.8229241403691533 0.7967616348440412 22.666828660258872 -13.999999999999998 0.2692843776907746 2.3614996284950145 0.7880169468891395 0.9995817881914424 0.0018461351359320452 14.848157294600606 0.16426619055718164 11.062294408661714 0.010904909257344395 1.0000000000000041e-14 13.999999999999998 -1.5734826816058751 TVQVVPHITDAIQEWVMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVQVVPHITDAIQEWVMR 18 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8 A0A3B3IRI2 CTPS1 CTP synthase 1 0 25226300.0 6602000.0 9470100.0 9154200.0 False True 10015716.670851199 7780086.664770982 7344868.357571614 1.0 0.7767878146367115 0.7333342784093952 23.25576232055842 -13.999999999898174 0.2300801755856837 2.4095955414947667 0.7122229061992225 0.9995099013396372 0.002586177814237804 13.293709716475801 0.15187588632571375 8.560842610088343 0.0225449314384386 1.0000000002344633e-14 13.999999999898174 -1.6973726352955443 TVQVVPHITDAIQEWVMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVQVVPHITDAIQEWVMR 18 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8 A0A3B3IRI2 CTPS1 CTP synthase 1 0 14750600.0 6877100.0 3160100.0 4713400.0 False True 5718613.357186703 3143075.91406926 5698950.147700718 1.0 0.5496220355795325 0.9965615424128519 22.44723393569315 -10.937714958651826 10.267926270664333 1.0520369698584286 0.7730917889961922 0.25576966592733474 0.18246228960546468 0.10650355559769778 0.0006460476272710106 0.08656715653561432 0.05888945074606995 1.154210554549472e-11 10.937714958651826 -0.2789451808622364 TVQVVPHITDAIQEWVMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVQVVPHITDAIQEWVMR 18 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8 A0A3B3IRI2 CTPS1 CTP synthase 1 0 19260600.0 6602000.0 7858700.0 4799900.0 False True 8546419.14487586 7421356.436647504 3926367.4511330193 1.0 0.868358585138794 0.459416673179098 23.02688864265087 -6.950664403215166 0.551506512267762 1.0056056987394972 0.30290853671579604 0.9992523618594993 0.00629345818648988 0.08322014363903131 0.03486743420696229 0.00681762339927877 0.03393491147935393 1.120303252379225e-07 6.950664403215166 -0.7026971620237012 down TVSFHLYISTAPCGDGALFDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVSFHLYISTAPCGDGALFDK 21 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISU1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 231457000.0 66494000.0 66345000.0 98618000.0 False True 100876259.3625535 54505216.3941491 79126109.07419516 1.0 0.5403175805543609 0.7843878190388941 26.588011443652952 -10.035789341925668 5.084913095012414 1.0000042221715972 0.6623526997948646 0.7184474986479182 0.09964125762054975 4.769471376027164e-06 9.044540676055457e-07 0.09647843876934714 0.03215907761241643 9.208961516117951e-11 10.035789341925668 -0.3376515223767327 TVSFHLYISTAPCGDGALFDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVSFHLYISTAPCGDGALFDK 21 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISU1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 138607000.0 66494000.0 22951000.0 49162000.0 False True 86077793.79269528 21673756.674449563 40215020.44471792 1.0 0.2517926600982289 0.46719390301254027 26.359137765745402 -10.197767378106011 5.064667669217323 1.0000553963583947 0.3594932815563441 0.9218099173313964 0.08793718918549319 5.50103765252364e-05 8.71353612521917e-06 0.08515214563871124 0.0283816057686982 6.342093229166372e-11 10.197767378106011 -0.6405621148020506 TVSLGAGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVSLGAGAK 9 0 P06748-2;P06748;P06748-3;E5RGW4 P06748-2 NPM1 Nucleophosmin 0 93929000.0 30767000.0 23203000.0 39959000.0 False True 29790318.426004358 32468078.902046517 29492539.1556956 1.0 1.08988693701591 0.9900041595376562 24.82834020871748 -6.669582294083635 1.9389333663789003 1.0573948276800673 0.990409152160182 0.27719912821430315 0.03818562726256455 0.46205459568676294 3.3485463121436294 0.015857466934497924 0.042389029907086755 2.1400193779387167e-07 6.669582294083635 -0.06698567551988532 TVSLGAGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVSLGAGAK 9 0 P06748-2;P06748;P06748-3;E5RGW4 P06748-2 NPM1 Nucleophosmin 0 56781000.0 24748000.0 18110000.0 13923000.0 False True 32036773.856011443 17102162.58003056 11389156.862044027 1.0 0.5338291132838732 0.35550261437785013 24.93322553804197 -13.999999999999996 0.13313916762164416 3.217131993737368 0.11544652091814744 0.9996316437297491 0.005215038988666788 11.933145949990099 0.11376847984422504 6.905309602834834 0.2137703090247855 1.0000000000000082e-14 13.999999999999996 -3.101685472819221 TVSLGAGAKDELHIVEAEAMNYEGSPIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVSLGAGAKDELHIVEAEAMNYEGSPIK 28 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 0 56247900.0 7309900.0 36555000.0 12383000.0 False True 11089652.725273423 30031474.644481428 9935494.622338286 1.0 2.708062676844642 0.8959247749656939 23.40271085213042 -6.6595811046041185 1.9751735174925409 2.0998765055071735 0.903599089587906 0.23357757093634512 0.7273340820839053 0.48538093262897525 3.6400323247859516 0.29760974228002046 0.8058469846734604 2.189872830575581e-07 6.6595811046041185 -1.1962774159192675 TVSLGAGAKDELHIVEAEAMNYEGSPIK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TVSLGAGAKDELHIVEAEAMNYEGSPIK 28 1 P06748-2;P06748;P06748-3 P06748-2 NPM1 Nucleophosmin 0 41730400.0 12556900.0 13842700.0 15330800.0 False True 16255154.583503699 13072341.576288737 12540751.707291843 1.0 0.8041966939862268 0.7714938447905404 23.954393940067167 -13.999999999999998 0.2518158718547633 2.3742808462837486 0.7585698197461688 0.9995461283253079 0.0021495477483909923 14.07076569857314 0.15878913749619547 9.791984640227541 0.014941354106808318 1.0000000000000041e-14 13.999999999999998 -1.6157110265375798 TVSLLDENNVSSYLSK(ub)NILAFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVSLLDENNVSSYLSKNILAFR 22 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 62962300.0 8665300.0 16100000.0 38197000.0 True False 13145893.61828641 13226829.210125862 30647346.20766014 1.0 1.0061567204322168 2.3313246780750285 23.648108879568078 -6.907919229812226 0.9097867162536266 0.9562214960646058 2.495172384272264 0.990112397890265 0.06226175407733973 0.10581014230463878 0.1463495096844672 0.05045580226782474 0.13735260318121786 1.236177316609054e-07 6.907919229812226 1.5389508882076581 up TVSPDRLELEAAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVSPDRLELEAAQK 14 1 Q14974;J3QR48 Q14974 KPNB1 Importin subunit beta-1 0 8855100.0 1447400.0 3737400.0 3670300.0 False True 1897555.41664154 3179794.488271093 3290532.5640036417 1.0 1.6757320815952623 1.7340903644477035 20.85571058837545 -11.317625551927902 0.4181339459632251 1.4373560885506725e-16 1.7368300886200074 0.9996669309745515 0.00608006835003617 3.511025710828778 0.2072823009543951 3.2480528809662705 0.014206739205153153 4.8125410621429975e-12 11.317625551927902 1.7368300886200072 TVSPDRLELEAAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVSPDRLELEAAQK 14 1 Q14974;J3QR48 Q14974 KPNB1 Importin subunit beta-1 0 8799600.0 1447400.0 3315600.0 4036600.0 False True 1982542.8945142645 3169105.828777012 3083238.2163865687 1.0 1.5985055544301163 1.5551936984152777 20.918920649898343 -10.219111800112536 4.97566718166932 0.999924908640048 1.5768496264232592 0.9957896589187375 0.017681991177015494 1.4732060781692814e-05 2.31207288544231e-06 0.01712273034646915 0.00570683811272458 6.037931753301491e-11 10.219111800112536 0.5769247177832112 TVSQIISLQTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVSQIISLQTLK 12 0 O76021;J3QSV6;I3L3U9;I3L3C4;I3L234 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 48139000.0 15251000.0 14013000.0 18875000.0 False True 19994208.690894093 11922315.02224617 16921996.06178482 1.0 0.5962884156388704 0.8463448753284023 24.253078849069833 -10.387054559281397 5.956202132598857 1.0000622707488322 0.7213166454836363 0.6235071136826027 0.10208512218769797 8.44335298889094e-05 8.688791839665659e-06 0.09886550842589158 0.032947831510708514 4.1015257335342393e-11 10.387054559281397 -0.278745625265196 TVSQIISLQTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVSQIISLQTLK 12 0 O76021;J3QSV6;I3L3U9;I3L3C4;I3L234 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 41259000.0 12671000.0 12752000.0 15836000.0 False True 12268766.040754749 17843940.1008015 11688076.530183343 1.0 1.4544201137691415 0.952669281601552 23.548486818150742 -6.668291642137224 1.9443049222313515 1.2904921350417191 0.9547495219077388 0.2711916293213432 0.19310625471554424 0.4650108021886806 3.3876531654987376 0.0800209330685079 0.21420497014283366 2.146388623910713e-07 6.668291642137224 -0.33574261313398035 TVSQIISLQTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVSQIISLQTLK 12 0 O76021;J3QSV6;I3L3U9;I3L3C4;I3L234 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 33901500.0 10538000.0 16188000.0 7175500.0 False True 15986916.430995129 13299124.922578702 5757259.279866625 1.0 0.8318755514850013 0.36012318602632837 23.930388361709362 -6.9529439586175 0.5255377084106535 1.0076867836363117 0.16305933131524863 0.9994124867940544 0.006565145895673348 0.08232481890051306 0.031234203402983603 0.007373578023927275 0.038990043937210755 1.1144383314938598e-07 6.9529439586175 -0.8446274523210631 down TVSQIISLQTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVSQIISLQTLK 12 0 O76021;J3QSV6;I3L3U9;I3L3C4;I3L234 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 42640000.0 15251000.0 13468000.0 13921000.0 False True 20889706.84277811 12872939.227279784 10633146.511994617 1.0 0.6162335988803096 0.509013677981348 24.316288910592725 -13.999999999999998 0.17889006814863875 2.9844833227209566 0.42286021110392213 0.9994995181323157 0.004715371265245375 12.190570823025634 0.13406874545426706 8.406637630467966 0.08081578015333667 1.0000000000000041e-14 13.999999999999998 -2.5616231116170347 TVSQIISLQTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVSQIISLQTLK 12 0 O76021;J3QSV6;I3L3U9;I3L3C4;I3L234 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 25645600.0 12671000.0 6215000.0 6759600.0 False True 10536497.920477062 6181518.56141909 8173001.107140867 1.0 0.5866767694611008 0.7756847833906104 23.32889209358502 -10.09710055666348 5.013487045677396 1.0000094813424305 0.6811807764247062 0.791394508906557 0.07716219857467975 8.177672242821806e-06 1.4726788311765414e-06 0.07471419821260013 0.024903992502469618 7.996490826024657e-11 10.09710055666348 -0.3188287049177243 TVSQIISLQTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVSQIISLQTLK 12 0 O76021;J3QSV6;I3L3U9;I3L3C4;I3L234 O76021 RSL1D1 Ribosomal L1 domain-containing protein 1 0 26785300.0 10538000.0 10005000.0 6242300.0 False True 13641648.735035101 9448212.954898162 5106265.45140684 1.0 0.6926005161408997 0.37431439194682514 23.70151468380181 -7.104015604386444 0.25699849308691364 1.0996023836773063 8.826587387817649e-11 0.999978481912762 0.0011849475560876009 0.07686389689407394 0.010150932092247204 0.008235295582304422 0.03170507390038017 7.870175113113548e-08 7.104015604386444 -1.0996023835890405 down TVSTLHHVLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVSTLHHVLQR 11 0 O00764;F2Z2Y4;O00764-2;O00764-3 O00764;O00764-3 PDXK Pyridoxal kinase 0 5258810.0 2225900.0 2406900.0 626010.0 False True 2918176.455646262 2047799.902022717 561236.4903119416 1.0 0.7017395737192353 0.1923243843688848 21.476635691781127 -7.244761312708442 0.4712742761785578 1.0151218089414058 4.254928642175684e-12 0.9991451972494858 0.00974958045824363 0.09370216303594014 0.037754612875537365 0.01169503259046333 0.05063905459138726 5.69165657091789e-08 7.244761312708442 -1.015121808937151 down TVSTLHHVLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVSTLHHVLQR 11 0 O00764;F2Z2Y4;O00764-2;O00764-3 O00764;O00764-3 PDXK Pyridoxal kinase 0 7760400.0 2539200.0 1527200.0 3694000.0 False True 2458594.485887807 2137018.92424279 2726430.582375424 1.0 0.8692034967576627 1.1089387038102383 21.22940236955181 -6.758568129805301 1.617994565196128 0.9238904870967206 1.1097490333893507 0.6850445801286291 0.05500239564522843 0.2853288901030307 1.4718870525891417 0.02682667940001546 0.06455676550908564 1.7435398187699463e-07 6.758568129805301 0.1858585462926301 TVSTLHHVLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVSTLHHVLQR 11 0 O00764;F2Z2Y4;O00764-2;O00764-3 O00764;O00764-3 PDXK Pyridoxal kinase 0 6378900.0 2539200.0 2430200.0 1409500.0 False True 2111457.3056329656 2417108.0302430703 1704219.9332083347 1.0 1.1447581837410052 0.8071297149422821 21.009807644986086 -6.790177339972718 1.4954769433761008 1.0808851652905584 0.8035133949061185 0.8019600853878137 0.06154668465105632 0.2350768752896447 1.0385871907038524 0.03239275750216118 0.07583441169682946 1.6211479820048394e-07 6.790177339972718 -0.27737177038443994 TVSVSEAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVSVSEAIK 9 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 3180370.0 698530.0 901740.0 1580100.0 False True 915779.5945741417 767203.9069549892 1416606.409389467 1.0 0.8377604300211083 1.5468857548067787 19.80464089363623 -6.846529677146246 1.2516738857297955 0.9136144811387402 1.5733991768266322 0.935109974520693 0.07727735034627611 0.1613141622225667 0.48807873526252127 0.04835050217067662 0.11166884375274082 1.4238699443729105e-07 6.846529677146246 0.659784695687892 TVTAMDVVYALK ddPTM_RPMI8226_Bortezomib_1h_R1 2 TVTAMDVVYALK 12 0 P62805 P62805 HIST1H4A Histone H4 0 228862000.0 69883100.0 91117100.0 67861800.0 False True 91617420.84890312 77522783.851674 60840111.9123511 1.0 0.8461576754002472 0.6640670665974058 26.449118613873054 -6.968894779583383 0.28334460706156805 1.038533897510185 0.4661166564262384 0.9999724300839975 0.0007209281177708285 0.07666299606210455 0.010307952755445854 0.0032999389552280083 0.01664422900989844 1.0742496489057532e-07 6.968894779583383 -0.5724172410839465 TVTAMDVVYALK ddPTM_RPMI8226_Bortezomib_2h_R1 2 TVTAMDVVYALK 12 0 P62805 P62805 HIST1H4A Histone H4 0 463711000.0 195587000.0 47752000.0 220372000.0 False True 189378197.74391106 66819622.62339038 162649962.18171036 1.0 0.3528369338150953 0.8588631855165066 27.496695008504727 -10.042376337217323 7.04774566534798 1.0000000702382124 0.6058500596658883 0.4471896460333329 0.20658435218693827 2.2794394426845097e-07 3.129571124451134e-08 0.2000244746686609 0.06667481296725487 9.070342004354808e-11 10.042376337217323 -0.394150010572324 TVTAMDVVYALK ddPTM_RPMI8226_Bortezomib_8h_R1 2 TVTAMDVVYALK 12 0 P62805 P62805 HIST1H4A Histone H4 0 1258223000.0 165432000.0 854033000.0 238758000.0 False True 250972438.69922024 701624138.5597144 191567376.64865118 1.0 2.7956222691073305 0.7633004549883524 27.902953698035112 -6.673506707387536 1.9252666415035575 2.142676661957654 0.7714296536188556 0.29457922791722135 0.762131794211626 0.45308524690491647 3.2411326900851747 0.3183364854925647 0.8465449609427655 2.1207686389852745e-07 6.673506707387536 -1.3712470083387982 TVTAMDVVYALK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TVTAMDVVYALK 12 0 P62805 P62805 HIST1H4A Histone H4 0 875404100.0 69883100.0 349758000.0 455763000.0 False True 95720770.5897677 334304535.0649625 348121166.13362545 1.0 3.49249732325806 3.6368404055748242 26.512328675395946 -10.295251817055792 0.593160017137178 1.8788448084631462e-18 3.6208534099940652 0.9997272842382643 0.01998919973738923 1.6148760736996388 0.28586974428330536 2.6784384145253943 0.02526824654722814 5.066968249609648e-11 10.295251817055792 3.6208534099940652 TVTAMDVVYALK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TVTAMDVVYALK 12 0 P62805 P62805 HIST1H4A Histone H4 0 555460700.0 195587000.0 204244800.0 155628900.0 False True 162639256.47323382 203144492.72298118 188170183.44326818 1.0 1.2490495660647187 1.1569788716676535 27.277100283939003 -10.141304610492268 4.239273703964077 0.9999538136470233 1.2030142188855037 0.8663565007746636 0.037587703659147494 26271290.592945345 1.0954792043691426 11919.841343137932 0.01286727072657247 7.222630366904069e-11 10.141304610492268 0.20306040523848046 TVTAMDVVYALK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TVTAMDVVYALK 12 0 P62805 P62805 HIST1H4A Histone H4 0 816165000.0 165432000.0 386584000.0 264149000.0 False True 214154985.15224177 365070260.5653529 216076592.3976202 1.0 1.7047012018227183 1.008972974614681 27.674080020127562 -10.577426376455161 4.953296824371084 0.9971203652931946 1.3568370882187069 0.2596713424322551 0.28402985938516045 0.009095320790837113 0.0007759351553655472 0.276930123658077 0.09167024293535986 2.645901201723508e-11 10.577426376455161 0.35971672292551227 TVTAMDVVYALK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVTAMDVVYALKR 13 1 P62805 P62805 HIST1H4A Histone H4 1 26118300.0 9706500.0 9907900.0 6503900.0 True False 12725315.497879717 8429679.940691704 5830938.817814162 1.0 0.6624338659498266 0.458215658290414 23.601198089595727 -9.269125108673379 0.12194579782290611 1.6147255788719912 4.93225433713108e-12 0.999910488834006 0.002113629960423021 0.7150857456480014 0.043963936470931886 0.35544921366294063 0.20554544264389932 5.381147436604022e-10 9.269125108673379 -1.614725578867059 TVTAMDVVYALK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 2 TVTAMDVVYALKR 13 1 P62805 P62805 HIST1H4A Histone H4 1 60194500.0 20909300.0 13998100.0 25287100.0 True False 20245545.716672186 19587614.329127137 18663649.91326089 1.0 0.9675024127898294 0.921864501676109 24.271101195451433 -6.966330469127758 0.3344573146067796 1.0052789617667448 0.8825839779693354 0.9999379469398724 0.00025239359445115725 0.07751260897778083 0.013285244433783195 0.0006557639466643011 0.003966653659056536 1.080611365212669e-07 6.966330469127758 -0.1226949837974094 TVTAMDVVYALK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVTAMDVVYALKR 13 1 P62805 P62805 HIST1H4A Histone H4 1 51080600.0 9144600.0 17453000.0 24483000.0 True False 13873026.759810004 14338375.789088614 19643924.31871989 1.0 1.033543439174119 1.4159797035516508 23.725779247473618 -6.924143196598272 0.7933710696668903 0.9927545546051323 1.483942898636483 0.9952571618006205 0.012994478842206955 0.09579420022624392 0.09342090339674608 0.011449332902337619 0.03578241298908037 1.1908492936569448e-07 6.924143196598272 0.4911883440313508 TVTAMDVVYALK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVTAMDVVYALKR 13 1 P62805 P62805 HIST1H4A Histone H4 1 30659260.0 9706500.0 10374760.0 10578000.0 True False 13295255.358299505 9916368.798456572 8079694.260748436 1.0 0.7458577162465948 0.6077126044596595 23.664408151118618 -13.99999994124365 0.07430690288842132 2.423008585166698 0.14792618437429056 0.9999090731926134 0.001549208887839342 12.315854291914594 0.07500060315687349 2.963584122120924 0.42075538001275176 1.0000001352915027e-14 13.99999994124365 -2.2750824007924075 TVTAMDVVYALK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TVTAMDVVYALKR 13 1 P62805 P62805 HIST1H4A Histone H4 1 61204700.0 20909300.0 25982500.0 14312900.0 True False 17387009.389048304 25842527.11537758 17305661.21462757 1.0 1.4863123690296745 0.9953213245245055 24.05150647088571 -10.597827074382367 3.0667267344198206 0.9859664897776105 1.2408168461145823 0.2428538551927093 0.20044625673192729 35960653.85166063 33090522.02982746 3983901.577332237 0.07082844523869468 2.5244857619008728e-11 10.597827074382367 0.25485035633697184 TVTAMDVVYALK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVTAMDVVYALKR 13 1 P62805 P62805 HIST1H4A Histone H4 1 38778500.0 9144600.0 19214900.0 10419000.0 True False 11837864.967014784 18145573.923745424 8522848.907967871 1.0 1.532841772930046 0.7199650386041802 23.496905569566067 -6.729860601420411 1.723791628873375 1.3207078517270696 0.7204632087599174 0.558632950342478 0.22399563207354664 0.33648051963526776 1.9587226998376182 0.10297937641829545 0.25557149306002275 1.862684919908059e-07 6.729860601420411 -0.6002446429671522 TVTAMDVVYALKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVTAMDVVYALKR 13 1 P62805 P62805 HIST1H4A Histone H4 0 21151700.0 6808500.0 5835800.0 8507400.0 False True 8926009.43360779 4965121.387770227 7627135.856743199 1.0 0.5562532086371975 0.8544844046462539 23.08958390065201 -9.973983421121712 5.451527606528797 1.000000751486217 0.7053688066411327 0.5654701364920838 0.1217523759357749 1.1120423973546684e-06 2.091278589121612e-07 0.11788653146466367 0.03929541036306813 1.0617360874336821e-10 9.973983421121712 -0.29463194484508437 TVTAMDVVYALKR ddPTM_RPMI8226_Bortezomib_8h_R1 2 TVTAMDVVYALKR 13 1 P62805 P62805 HIST1H4A Histone H4 0 472258200.0 41283200.0 253839000.0 177136000.0 False True 62629632.60619259 208539447.19684076 142124991.95853326 1.0 3.3297249004813922 2.269293081315001 25.900342080136838 -10.628425099028165 6.982026296228198 0.9954206976746666 2.7995089908971904 0.7933695766175117 0.43291947732816694 0.03077148615666015 0.001637618082202616 0.417967475008687 0.139724160495067 2.3527452266320638e-11 10.628425099028165 1.8040882932225237 TVTAMDVVYALKR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TVTAMDVVYALKR 13 1 P62805 P62805 HIST1H4A Histone H4 0 108845060.0 7769560.0 77329300.0 23746200.0 False True 10642176.29646418 73912635.83220117 18137836.628340397 1.0 6.94525572337665 1.7043352903641165 23.343289872481193 -6.615775647814252 2.1324743350984283 4.956447004657357 1.7238919333175955 0.06876808069998508 2.5594212631259396 0.5967974348453255 5.151010752650494 0.9882790282902274 2.8389814969791836 2.422280049227627e-07 6.615775647814252 -3.2325550713397613 TVTAMDVVYALKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVTAMDVVYALKR 13 1 P62805 P62805 HIST1H4A Histone H4 0 18829000.0 5302800.0 8913200.0 4613000.0 False True 4409513.153871498 8865182.822468318 5577556.971897869 1.0 2.0104674854376605 1.264891786749937 22.072187948629068 -10.048209074670293 4.349983134412228 0.9999556217771957 1.6376796358081123 0.4937605156460172 0.3043800047229544 56210221.520276494 109599699.92067455 35306.3251946076 0.11139168419239681 8.949338297480744e-11 10.048209074670293 0.6377240140309166 TVTAMDVVYALKR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TVTAMDVVYALKR 13 1 P62805 P62805 HIST1H4A Histone H4 0 404822200.0 41283200.0 158395000.0 205144000.0 False True 53441916.21353203 149580179.0096047 167809896.95519325 1.0 2.798929933798472 3.140042663977346 25.671468402229287 -10.1212618858853 0.38395459783482633 1.601048868008293e-16 3.18488442072239 0.9989679504638429 0.030159787984545373 1.4825302827176958 0.1745800381377607 1.7084842564608773 0.09069661448413857 7.563766513588942e-11 10.1212618858853 3.18488442072239 TVTAMDVVYALKRQGRTLYGFGG ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVTAMDVVYALKRQGRTLYGFGG 23 3 P62805 P62805 HIST1H4A Histone H4 0 4425260.0 2055200.0 831660.0 1538400.0 False True 2694387.1025851127 707579.56978529 1379221.1253748215 1.0 0.2626124394324807 0.5118867753083944 21.361525707006415 -10.244616820823166 5.504828432890048 1.0000425626633311 0.3872496073716606 0.88958305976957 0.10176582147796674 5.316273976060908e-05 7.2948761758940745e-06 0.09854114904128293 0.03284477764975756 5.693550527773566e-11 10.244616820823166 -0.6127929552916705 TVTAMDVVYALKRQGRTLYGFGG ddPTM_RPMI8226_Bortezomib_2h_R1 2 TVTAMDVVYALKRQGRTLYGFGG 23 3 P62805 P62805 HIST1H4A Histone H4 0 234608800.0 73935800.0 14075200.0 146597800.0 False True 71588748.49941085 19695500.76119836 108199438.34026983 1.0 0.2751200597026842 1.5114028476298935 26.093229523214283 -6.747775905593235 1.6580353142483133 0.5726410062056744 1.5134605327319908 0.6394245795264979 0.30457050484941545 0.3039086574597246 1.6430747856538164 0.14515338290875726 0.3532256210256396 1.7874096339507138e-07 6.747775905593235 0.9408195265263164 TVTAMDVVYALKRQGRTLYGFGG ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TVTAMDVVYALKRQGRTLYGFGG 23 3 P62805 P62805 HIST1H4A Histone H4 0 17571470.0 2347040.0 6005730.0 9218700.0 False True 3214804.11437112 5740376.990306719 7041432.925086172 1.0 1.785607080893528 2.190314767114082 21.61629940272964 -9.653747601926172 0.1703162351664163 7.594701627806888e-14 2.700525525151377 0.9996536557599933 0.009196621521710188 1.1182240618788106 0.07142266110440393 0.8299345681456308 0.2913505035701047 2.2194859393484238e-10 9.653747601926172 2.700525525151301 TVTAMDVVYALKRQGRTLYGFGG ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TVTAMDVVYALKRQGRTLYGFGG 23 3 P62805 P62805 HIST1H4A Histone H4 0 402250200.0 73935800.0 165286000.0 163028400.0 False True 61480893.611302026 164395571.51129767 197116884.6818461 1.0 2.673929441407417 3.2061486602336915 25.87363479864856 -9.76687048329489 0.3045774625178541 4.584228492420344e-25 3.3942129212044785 0.998786741888784 0.03274192035573165 1.1444440164794232 0.13039756116179804 1.2549376878102023 0.18474554603951251 1.7105253574380258e-10 9.76687048329489 3.3942129212044785 TVTATFGYPFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVTATFGYPFR 11 0 A0A0U1RQT9;C9JYN0;Q16563-2;Q16563 A0A0U1RQT9 SYPL1 Synaptophysin-like protein 1 0 5913400.0 2127200.0 1603100.0 2183100.0 False True 2913683.3254185 1532269.741257217 1667496.7423558244 1.0 0.525887534822314 0.5722985500204685 21.474412655486155 -10.26280652050025 8.543780552347593 1.0000002268128978 0.5490930430077847 0.9921169832174024 0.018947217613338944 8.1855535181099e-08 7.0712114167194606e-09 0.01834557386257963 0.00611518818945246 5.460010520292935e-11 10.26280652050025 -0.4509071838051131 TVTITK(ub)EDESTEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVTITKEDESTEK 13 1 Q9NS91;H7C3I2 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 6904020.0 586310.0 2967910.0 3349800.0 True False 567697.9099798686 4153011.9404461905 2472386.8881540913 1.0 7.31553149560382 4.355110076487275 19.114763904675232 -9.438819153956647 9.560143127477279 0.9999011147693144 5.8353207860666645 0.7805567443574202 1.2085869847554143 0.0 0.0 1.1702093154908806 0.39006977183029345 3.640666067818403e-10 9.438819153956647 4.83541967129735 TVTITK(ub)EDESTEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVTITKEDESTEK 13 1 Q9NS91;H7C3I2 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 7853860.0 586310.0 5032650.0 2234900.0 True False 487542.742937014 5005538.115547191 2702207.256989934 1.0 10.266870316627521 5.542503290504386 18.89516918010951 -9.797929392367873 11.70349281305013 0.9999839465695012 7.904686803566005 0.7401245008910318 1.9287147619608846 0.0 0.0 1.8674700381546647 0.6224900127182215 1.5924676095192765e-10 9.797929392367873 6.904702856996503 TVTITK(ub)EDESTEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVTITKEDESTEK 13 1 Q9NS91;H7C3I2 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 24962100.0 4583200.0 6793000.0 13585900.0 True False 5933042.748378523 6414963.578473095 11113405.603105929 1.0 1.0812265898853128 1.873137625064842 22.50034074697317 -6.926612846582675 0.7740850962861687 0.9863254478308238 2.0225276291758583 0.9958297521300887 0.02543410158819691 0.09443499327022772 0.0865772519400307 0.022720844306421597 0.07303413879613051 1.1840966526975754e-07 6.926612846582675 1.0362021813450344 TVTIVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVTIVVR 7 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 86374000.0 29450000.0 34921000.0 22003000.0 False True 38609235.19420573 29710922.920991845 19726340.627679516 1.0 0.7695289163731144 0.5109228537798112 25.202442640598147 -6.969632692011345 0.2668129437429958 1.0668227639233516 0.2058874565774871 0.9999793737659531 0.0009072820661153286 0.07642208752059237 0.009455776280503439 0.005170042014851114 0.024158970779021995 1.072425934494557e-07 6.969632692011345 -0.8609353073458645 TVTIVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVTIVVR 7 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 60922000.0 21114000.0 11724000.0 28084000.0 False True 20443747.62721926 16405454.339852309 20727957.898059417 1.0 0.8024680522865447 1.0139020631648648 24.28515635107481 -11.123509891095573 11.310827547145205 3.290405848914817 0.9081850577257048 0.20091366384566978 0.08631757348699197 0.038158296273662275 0.0004166747543021136 0.0006396866793126314 0.027858877050012897 7.524715923707764e-12 11.123509891095573 -2.3822207911891122 TVTIVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVTIVVR 7 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 194787000.0 54336000.0 71964000.0 68487000.0 False True 82431684.49369444 59121461.94270164 54950514.43108157 1.0 0.717217685236362 0.6666188464859647 26.296695640888924 -13.999999999999998 0.24203067063375394 2.890335467016214 0.644673784967096 0.999528374869634 0.003185712936075322 13.696044937467928 0.15569936620976757 12.528044403262502 0.02443300078406346 1.0000000000000041e-14 13.999999999999998 -2.2456616820491178 TVTIVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVTIVVR 7 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 78831000.0 29450000.0 19890000.0 29491000.0 False True 40338460.85632522 19011194.03256568 22525833.186210237 1.0 0.47129200343757427 0.558420740603892 25.265652702121038 -10.789295849551777 7.1643448239757666 1.0150076655215672 0.5148563720207331 0.976380932879851 0.035570157998424466 0.00828272092525593 0.00024359543209814588 0.03345547322801117 0.011480219129155377 1.6244417785199097e-11 10.789295849551777 -0.5001512935008341 TVTIVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVTIVVR 7 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 47757000.0 21114000.0 14984000.0 11659000.0 False True 17557226.508795854 14903278.217908878 14096842.994874772 1.0 0.8488401177966579 0.8029083060364066 24.065561626509087 -13.999999999998556 0.16687689453632648 1.7562731575278452 0.7610141005805435 0.9995199835458713 0.0018447148234149802 12.062692911893437 0.12929352318945683 2.9524653693183494 0.03853997769351794 1.0000000000033254e-14 13.999999999998556 -0.9952590569473017 TVTIVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVTIVVR 7 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 192601000.0 54336000.0 83647000.0 54618000.0 False True 70339023.12268625 78991970.91837758 44678084.42800552 1.0 1.1230177419524114 0.6351820432603593 26.067821962981373 -6.839901350603571 1.2830218536794922 1.0654404398255455 0.6191848793076955 0.9242561360539178 0.05701167029883607 0.16891609566341984 0.540204702678957 0.03484545785899236 0.08026749130620478 1.4457681377017336e-07 6.839901350603571 -0.44625556051785 TVTNAVVTVPAYFNDSQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVTNAVVTVPAYFNDSQR 18 0 P11142;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 486230000.0 147110000.0 195190000.0 143930000.0 False True 192862634.6152664 166068412.844661 129037504.27404974 1.0 0.861070954339828 0.6690643033652488 27.522998420490577 -6.966582667683832 0.32976575349422593 1.0234565108957474 0.5003953795153098 0.9999421456286524 0.0010320085569407663 0.07742796763988612 0.01298826740245899 0.0028040230237976935 0.016750408495663848 1.0799840270290455e-07 6.966582667683832 -0.5230611313804376 TVTNAVVTVPAYFNDSQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVTNAVVTVPAYFNDSQR 18 0 P11142;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 476422000.0 160260000.0 94892000.0 221270000.0 False True 155172634.02188867 132782870.45524271 163312749.04228744 1.0 0.8557106173535234 1.0524584445685863 27.209298907847618 -6.7101111351076135 1.7945222151249254 0.9113068662778524 1.0520039026518075 0.4657878446809235 0.060801387763940146 0.3748383430949683 2.353034524241764 0.026960389047738554 0.06849017615603242 1.9493457021787492e-07 6.7101111351076135 0.14069703637395514 TVTNAVVTVPAYFNDSQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVTNAVVTVPAYFNDSQR 18 0 P11142;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 892710000.0 137010000.0 584520000.0 171180000.0 False True 207854186.77269343 480207839.12439567 137346197.96914062 1.0 2.3103111204083877 0.6607814838935171 27.630996567322757 -6.695019818495929 1.8483515306602352 1.8175653928054945 0.6660718244470274 0.39414776690367337 0.5536148174889542 0.40595181735253133 2.6926143787059162 0.23925829294014855 0.6191838642231804 2.0182742601100336e-07 6.695019818495929 -1.151493568358467 TVTNAVVTVPAYFNDSQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVTNAVVTVPAYFNDSQR 18 0 P11142;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 476620000.0 147110000.0 147300000.0 182210000.0 False True 201500542.498268 140791798.94403848 139175750.7327447 1.0 0.6987167240269274 0.6906966552407221 27.58620848201347 TVTNAVVTVPAYFNDSQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVTNAVVTVPAYFNDSQR 18 0 P11142;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 335731000.0 160260000.0 101980000.0 73491000.0 False True 133263290.72177808 101430613.49855494 88857628.31600827 1.0 0.7611294374406365 0.6667824862701445 26.989704183281894 -13.999999999999998 0.1282943941018462 2.1350481305223448 0.5317487927401726 0.999653403504953 0.0026107755399576403 11.939680960218151 0.11121398279054298 3.422817661109371 0.12001875358394187 1.0000000000000041e-14 13.999999999999998 -1.6032993377821723 TVTNAVVTVPAYFNDSQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVTNAVVTVPAYFNDSQR 18 0 P11142;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PI65;E9PN89 P11142;E9PN89 HSPA8 Heat shock cognate 71 kDa protein 0 534990000.0 137010000.0 230110000.0 167870000.0 False True 177362145.8708635 217304176.21705326 137319382.49165615 1.0 1.225200423405293 0.7742316254542709 27.402122889415207 -6.770940325760457 1.570990941498424 1.129013350784689 0.7716121356001584 0.7341087259455328 0.09493427237249613 0.2649046853136479 1.29042591650587 0.04762977204671007 0.11327477216602198 1.6945706269526073e-07 6.770940325760457 -0.3574012151845305 TVTPAK(ub)AVTTPGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVTPAKAVTTPGK 13 1 P19338;C9JYW2;C9JLB1;C9J1H7;C9JWL1 P19338 NCL Nucleolin 1 4130000.0 1178800.0 1851500.0 1099700.0 True False 1141379.639242498 2590813.6054449505 811655.5797071626 1.0 2.2698964624639717 0.7111179767021566 20.12234730184063 -6.690099849884319 1.8663299774330098 1.7960760746533968 0.7165364963487376 0.37081054045392214 0.5370661394631481 0.41643249050256176 2.812437632103977 0.2302169754202854 0.599366139171595 2.0412685768280773e-07 6.690099849884319 -1.0795395783046593 TVTSATIVYHLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVTSATIVYHLAR 13 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 22552700.0 9395100.0 8982200.0 4175400.0 False True 12317067.082277808 7642090.772341378 3743369.661264966 1.0 0.6204472802894013 0.3039172910449636 23.554155429206315 -7.677918711413794 0.25509751034306966 1.1414557817731572 3.0002018690373825e-10 0.9997652207245002 0.004360208455941787 0.1284068040430736 0.0329019555912634 0.03824300186246981 0.0780327029618644 2.099332787129254e-08 7.677918711413794 -1.141455781473137 down TVTSATIVYHLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVTSATIVYHLAR 13 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 26272820.0 9172800.0 5364620.0 11735400.0 False True 8881614.484936867 7506740.742123723 8661546.685546458 1.0 0.8452000202052322 0.9752220950634998 23.08239052041524 -10.318911547513279 4.783240951847219 1.000049591860308 0.9102110576420105 0.38869459135331896 0.05308128978374894 2.8087776030212225e-05 3.999457616274096e-06 0.05142410998654648 0.017131912610596982 4.798311656001114e-11 10.318911547513279 -0.08983853421829757 TVTSATIVYHLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVTSATIVYHLAR 13 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 34239100.0 15226900.0 4132200.0 14880000.0 False True 23100320.53550197 3394776.624974037 11938961.477864321 1.0 0.1469579878667371 0.516830987670314 24.461409534544245 -10.647243119677483 6.525326595903634 1.0033341965805687 0.3318944879411188 0.8130961252863647 0.151000019858551 0.007342485369212129 0.0003969317941859158 0.14656607144521383 0.04873504684909647 2.2529776337500225e-11 10.647243119677483 -0.6714397086394499 TVTSATIVYHLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVTSATIVYHLAR 13 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 19742900.0 9395100.0 1254700.0 9093100.0 False True 12868722.363030907 1199263.2052619504 6945497.05827299 1.0 0.09319209564324564 0.5397192403673204 23.617365490729206 -10.320108944376061 5.055466054870853 1.0002498046588713 0.31645566800513314 0.7575446140792584 0.18229394347983421 0.0005134411878764942 6.905031177050004e-05 0.17656833669821723 0.058835117267581526 4.7851004125308324e-11 10.320108944376061 -0.6837941366537381 TVTSATIVYHLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVTSATIVYHLAR 13 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 22103040.0 9172800.0 7393100.0 5537140.0 False True 7627589.623940644 7353271.902884554 6694930.373157297 1.0 0.9640361195894583 0.8777255598733291 22.862795795849518 -6.956331519231283 0.48438049747745743 1.0019886636482511 0.8361477727805703 0.9996089854878345 0.0010145814269476227 0.081038640257918 0.026179003501633952 0.0012279725594055728 0.007119027902018506 1.1057793636756066e-07 6.956331519231283 -0.16584089086768083 TVTSATIVYHLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVTSATIVYHLAR 13 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 55758200.0 15226900.0 26179300.0 14352000.0 False True 19711522.21707212 24722398.941545766 11740083.26395575 1.0 1.254210540885256 0.595594958860543 24.232535856636694 -6.802061916243899 1.44751339961939 1.1398943978858929 0.5860372278818069 0.8381140998876613 0.10911711425572984 0.21782777545526116 0.9008509653927099 0.05929766035312421 0.13773284928124535 1.5773863697626078e-07 6.802061916243899 -0.553857170004086 TVTSGSIQPVTQAPQAGQMVDTK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVTSGSIQPVTQAPQAGQMVDTKR 24 1 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 50445600.0 24382000.0 17697000.0 8366600.0 True False 31965038.11562391 15056676.58236572 7500904.49009423 1.0 0.47103577752364073 0.2346596447957285 24.92999147834703 -10.271010183083193 0.18401655240238127 1.7335780051110117 2.013780878229396e-21 0.9995057497002949 0.007113470304160776 1.9038644398150386 0.09001168304487031 0.8179521777778228 0.15864916273717602 5.357840946137405e-11 10.271010183083193 -1.7335780051110117 TVTSGSIQPVTQAPQAGQMVDTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 2 TVTSGSIQPVTQAPQAGQMVDTKR 24 1 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 103068200.0 50300500.0 34408500.0 18359200.0 True False 48703738.1606016 48147993.487957 13550374.755805895 1.0 0.9885892809539173 0.2782204255271587 25.537529172017944 -6.910390093174824 0.8930651471520068 1.0217245372583212 0.1856443763083949 0.9910680160264819 0.03190561277239968 0.10416126512920512 0.13736940829087757 0.026171938586658144 0.0724439913604695 1.2291642115837441e-07 6.910390093174824 -0.8360801609499263 down TVTSGSIQPVTQAPQAGQMVDTK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVTSGSIQPVTQAPQAGQMVDTKR 24 1 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 81441000.0 31896000.0 30684000.0 18861000.0 True False 48388563.90994694 25208200.464813735 15133115.082930036 1.0 0.5209536805375586 0.31274156247111135 25.528162787333216 -12.628705104100058 0.12959875823020764 2.625048792582604 2.823575560868726e-19 0.9996883429720209 0.005079748670302152 7.19770561708244 0.09803221392621599 3.3033138183906545 0.2529117281798037 2.3512288171454487e-13 12.628705104100058 -2.625048792582604 TVTSGSIQPVTQAPQAGQMVDTK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVTSGSIQPVTQAPQAGQMVDTKR 24 1 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 52135000.0 24382000.0 20249000.0 7504000.0 True False 33396684.29877492 19354332.225511465 5731709.749731169 1.0 0.5795285559597134 0.17162511399197267 24.993201539869922 -7.726233497704226 0.3799838445577143 1.055221328122714 2.8627687024694597e-21 0.99856092225331 0.012829509251028201 0.1186525757998987 0.061016676192726244 0.030645241070431477 0.07704441209266837 1.8783066768239082e-08 7.726233497704226 -1.055221328122714 down TVTSGSIQPVTQAPQAGQMVDTK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TVTSGSIQPVTQAPQAGQMVDTKR 24 1 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 109097100.0 50300500.0 51005000.0 7791600.0 True False 41827094.43997753 50730225.94130015 9420787.535712002 1.0 1.2128556052129975 0.22523169877914817 25.31793444745222 -6.850304284219594 1.2336337628560137 1.1136170483117582 0.1855210932487842 0.9407444683845545 0.10330736238468044 0.1571237989854987 0.4599947729650071 0.0655233552168856 0.15165356948009256 1.4115482105064803e-07 6.850304284219594 -0.928095955062974 down TVTSGSIQPVTQAPQAGQMVDTK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVTSGSIQPVTQAPQAGQMVDTKR 24 1 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 1 80371500.0 31896000.0 41911000.0 6564500.0 True False 41290000.764156364 39578616.00727007 5369828.3574580215 1.0 0.9585520773743376 0.13005154415302267 25.299289109425665 -6.917296893722094 0.8445488910244504 1.0201227408204132 0.004423445040640207 0.9933958756034975 0.03256203023796968 0.09978926273206035 0.11405536003284411 0.027660802838109566 0.08083013148465487 1.2097708235678816e-07 6.917296893722094 -1.015699295779773 down TVVLHGK(ub)SGIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVVLHGKSGIGK 12 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 45861000.0 12473000.0 20339000.0 13049000.0 True False 16352223.78870381 17304500.480801057 11698814.654846625 1.0 1.0582353020850341 0.7154265258360896 23.962983509768247 -6.863177189428074 1.1696723673777818 1.031900543315259 0.6977975242279254 0.9573812626969155 0.030919879795406873 0.14355927570889046 0.3714396710079923 0.020590552179538035 0.04824659103837902 1.370322569074057e-07 6.863177189428074 -0.33410301908733364 TVVLHGK(ub)SGIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVVLHGKSGIGK 12 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 53846000.0 10802000.0 19387000.0 23657000.0 True False 10459096.422715848 27128330.201869402 17460522.005212646 1.0 2.593754671096641 1.6694101765130092 23.31825488455598 -10.486409601598474 7.202702496388107 0.9997738236836642 2.1315824238048244 0.666468824518674 0.3773620597134512 0.0013708301910384034 9.774624883237668e-05 0.36544710207299264 0.12179308106339377 3.26279958503692e-11 10.486409601598474 1.1318086001211602 TVVLHGK(ub)SGIGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVVLHGKSGIGK 12 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 96114180.0 24867180.0 17382000.0 53865000.0 True False 37725330.09437398 14280046.293814132 43218559.14013176 1.0 0.37852674206139636 1.1456111591870999 25.169030188513737 -6.691140635167025 1.8622677133207917 0.6108118956003463 1.1430110827188806 0.37595256160923785 0.2627752986388331 0.414142699971693 2.785520353389021 0.11284340164032149 0.29344057112586613 2.036382540490295e-07 6.691140635167025 0.5321991871185343 TVVLHGK(ub)SGIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVVLHGKSGIGK 12 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 39651000.0 12473000.0 14389000.0 12789000.0 True False 17084605.17015088 13753246.401940059 9768501.597722806 1.0 0.8050081500255472 0.5717721598149486 24.026193571291138 -6.968746013312711 0.28656234768844074 1.047487750022144 0.3221209255476406 0.9999708794587084 0.0009446423962295343 0.07671177258016043 0.010479660053961523 0.004151704680422743 0.021236454084437934 1.0746176929298068e-07 6.968746013312711 -0.7253668244745034 TVVLHGK(ub)SGIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVVLHGKSGIGK 12 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 53619000.0 10802000.0 28061000.0 14756000.0 True False 8982341.60973822 27909829.82332763 17841411.375964675 1.0 3.1071886414416867 1.98627620181155 23.098660159990256 -10.346420712223201 10.634083214246377 0.999999826540511 2.5467324216266185 0.7174170488738639 0.4576105872386813 1.882494799136458e-06 1.148612602112949e-07 0.4430795920646778 0.14769318195196746 4.503801982782261e-11 10.346420712223201 1.5467325950861075 TVVLHGK(ub)SGIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVVLHGKSGIGK 12 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 74503180.0 24867180.0 14766000.0 34870000.0 True False 32191054.715400435 13944259.1196428 28524017.79641421 1.0 0.433171862274266 0.886085219903283 24.940156510606187 -9.985965392310863 6.97234715277454 1.0000000289568842 0.6596285410887819 0.4295605005872405 0.1849011039802964 8.321724388714483e-08 1.1861183486814061e-08 0.17902974010922879 0.05967657470092089 1.0328437068526591e-10 9.985965392310863 -0.34037148786810234 TVVLHGK(ub)SGIGK(ub)SALAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVVLHGKSGIGKSALAR 17 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 2 4381050.0 962950.0 2381900.0 1036200.0 True False 1262436.7752210665 2026529.8045734805 928983.9639322606 1.0 1.6052525119276668 0.7358657337668141 20.267779706607172 -6.7195185401924 1.7613364476238977 1.3684210972166706 0.7372834705870034 0.5101376894967553 0.2547072429634015 0.3562418578203827 2.159667080783653 0.11484157722225044 0.28842725576685807 1.9075742871984503e-07 6.7195185401924 -0.6311376266296672 TVVLHGK(ub)SGIGK(ub)SALAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVVLHGKSGIGKSALAR 17 2 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 2 3815050.0 962950.0 1520500.0 1331600.0 True False 1318978.6377452756 1453319.282378889 1017103.5051628493 1.0 1.101852024581127 0.7711296271647994 20.330989768130063 -6.824028099766433 1.3544623311275368 1.0546845321821519 0.7632728100564914 0.8933772050285872 0.04515809088112022 0.1882984461269241 0.6776712989322836 0.02619261780107725 0.06031159551198796 1.499587805878267e-07 6.824028099766433 -0.29141172212566047 TVVNK(ub)DVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVVNKDVFR 9 1 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 9666100.0 1157900.0 1788700.0 6719500.0 True False 1518018.113119552 1521832.9322979925 6024230.597995384 1.0 1.0025130261262831 3.9684840028789194 20.533757574538587 -6.907078965616272 0.9153773259922631 0.8994701194702688 4.328793730320835 0.9897722595178811 0.14146029300393181 0.10638202500475846 0.14947188473135958 0.11416811050212453 0.3091354603042014 1.2385713627542683e-07 6.907078965616272 3.4293236108505663 up TVVNK(ub)DVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVVNKDVFR 9 1 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 13355920.0 2949030.0 3115790.0 7291100.0 True False 2855414.6568674087 4359941.195630199 5381342.181688542 1.0 1.5269029964332264 1.8846097076465431 21.445268835041137 -8.013346322256954 0.10401899821805273 1.717330514672777e-16 3.0457851709890638 0.9999879371371061 0.001261910838902987 0.10788414938332494 0.0175900082555041 0.22889161321978171 0.25992973221809945 9.697363557007879e-09 8.013346322256954 3.0457851709890638 TVVNK(ub)DVFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVVNKDVFR 9 1 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 13077700.0 5306400.0 2876800.0 4894500.0 True False 8050196.749803803 2363412.5634590103 3927099.9296644423 1.0 0.2935844473014415 0.48782657762496956 22.940592612985903 -10.397089386323582 5.140688004308789 1.0004846764179791 0.39070551246343455 0.9291743081239732 0.07929901764075763 0.0004408324848523502 5.1701620702576934e-05 0.07683945999930342 0.025593647891088207 4.0078421988345244e-11 10.397089386323582 -0.6097791639545446 TVVNK(ub)DVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVVNKDVFR 9 1 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 13746800.0 1157900.0 1633700.0 10955200.0 True False 1586006.9210709322 1561517.7320765508 8367807.389426279 1.0 0.9845592168173861 5.27602198846397 20.59696763606148 -6.906088846182856 0.9219564645520201 0.8501400046660389 5.786618999463179 0.9893600540960432 0.20829982916425094 0.1070615822192225 0.15321644095079515 0.16730636586842423 0.4502361544864518 1.2413983214394083e-07 6.906088846182856 4.93647899479714 up TVVNK(ub)DVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVVNKDVFR 9 1 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 17775130.0 2949030.0 5743200.0 9082900.0 True False 2452249.1091803676 5712260.241664054 10982092.3954154 1.0 2.3293963978942185 4.478375526492095 21.225674110475413 -6.963984264190679 0.37507595496581697 0.8439649694793149 6.0392102739799824 0.9998906526901525 0.01498603167873112 0.07830734905503538 0.016085703919776498 0.028125453654424305 0.18202834564143255 1.0864649888332653e-07 6.963984264190679 5.195245304500667 TVVNK(ub)DVFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVVNKDVFR 9 1 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 15826400.0 5306400.0 3202400.0 7317600.0 True False 6869239.404781761 3024183.624864156 5985871.884916555 1.0 0.44025014221501513 0.8714024264097882 22.711718935078352 -9.87102658954662 6.509406968189551 1.0000000154109834 0.6558262843123845 0.45935299711049205 0.17601718295219873 3.936316067102689e-08 7.022503023636588e-09 0.1704279121737232 0.05680930151833711 1.345777956690442e-10 9.87102658954662 -0.34417373109859883 TVVNK(ub)DVFRDPALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVVNKDVFRDPALK 14 2 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 10720210.0 2558000.0 826710.0 7335500.0 True False 2476797.6901784088 1156819.6142356966 5414112.489717092 1.0 0.46706261832486146 2.1859324688433084 21.24004460048563 -6.8234209356622 1.3568999287447259 0.7136899578050675 2.2263135503194458 0.8920813861198703 0.23600350756625524 0.18908212646304529 0.683092770743422 0.13663883766267954 0.31469731962835434 1.50168576631657e-07 6.8234209356622 1.5126235925143783 up TVVNK(ub)DVFRDPALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVVNKDVFRDPALK 14 2 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 15936000.0 2558000.0 4017700.0 9360300.0 True False 2127090.338614182 3996055.8526489926 11317495.45286271 1.0 1.878648866062011 5.3206463531004315 21.020449875919905 -6.945354384509906 0.6077112677009456 0.9617950791920029 6.416045777261501 0.9987844321888609 0.06500589876472566 0.08540657760525493 0.04410839627811488 0.06622095628596768 0.29000658648338495 1.1340850240654878e-07 6.945354384509906 5.454250698069498 TVVNK(ub)DVFRDPALKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVVNKDVFRDPALKR 15 3 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 12248200.0 1657600.0 5368100.0 5222500.0 True False 2514700.386792324 4410120.613843271 4190270.5858969362 1.0 1.7537360064865173 1.6663100733212672 21.261955090135075 -10.359815849168859 6.185203406556461 0.9999220967315947 1.7100230399038285 0.9887568897998904 0.035691487756922345 3.8350480406192336e-05 3.9693544983237965e-06 0.03456188347337423 0.01151937814032701 4.367009642221806e-11 10.359815849168859 0.7101009431722338 TVVNK(ub)DVFRDPALKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVVNKDVFRDPALKR 15 3 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 15983400.0 1657600.0 4967400.0 9358400.0 True False 2145795.8761808854 4690959.823304462 7655267.2252928745 1.0 2.1861165245845715 3.5675654475195544 21.033081412227524 -6.969120732609367 0.27838676971422627 0.6896881625850693 5.105996973660871 0.9999746891098116 0.005278589276092592 0.07658905822531424 0.010047181262446586 0.025756505670580385 0.12705993477323382 1.0736908878885198e-07 6.969120732609367 4.416308811075802 TVVSGLVNHVPLEQMQNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVVSGLVNHVPLEQMQNR 18 0 Q12904;Q12904-2;A0A5F9ZHC5 Q12904 AIMP1 Aminoacyl tRNA synthase complex-interacting multifunctional protein 1;Endothelial monocyte-activating polypeptide 2 0 12103800.0 7221400.0 2575400.0 2307000.0 False True 6004914.062262888 2561525.809023127 2789383.0336371944 1.0 0.4265716016022123 0.46451672825206847 22.517712168654864 -9.913493416101508 5.788129114910288 1.0000002851192549 0.4455441670272662 0.9964996090427429 0.015491033088140786 5.70062949370811e-08 1.0676858970161066e-08 0.014999136001327469 0.004999709430215651 1.2204123220384316e-10 9.913493416101508 -0.5544561180919887 TVVSGLVQFVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVVSGLVQFVPK 12 0 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 0 51552000.0 14511000.0 17351000.0 19690000.0 False True 19024061.524723914 14762298.433668276 17652667.679816816 1.0 0.7759803769811722 0.9279126676958642 24.18132195015998 -10.063423043818466 4.703077393445122 1.0000058294113316 0.8519465224257984 0.5587176234931324 0.062026097962469426 86038330.08979115 2.520057840309913 5431.3648368174645 0.021233183128250507 8.641257686118783e-11 10.063423043818466 -0.14805930698553327 TVVSGLVQFVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVVSGLVQFVPK 12 0 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 0 63948000.0 26107000.0 11574000.0 26267000.0 False True 25278247.57524931 16195558.557612648 19386884.706891 1.0 0.6406915079615806 0.7669394268403827 24.591393115775205 -10.369016720831924 5.241268542177484 1.000146019065008 0.7038154674009685 0.8800762317271786 0.051540497056937806 8.798509442053688e-05 1.0592302109157768e-05 0.04992831752871963 0.01663462389639102 4.275464248106535e-11 10.369016720831924 -0.29633055166403954 TVVSGLVQFVPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVVSGLVQFVPK 12 0 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 0 55081000.0 11022000.0 24214000.0 19845000.0 False True 16721179.81613478 19892822.515154496 15922627.051627507 1.0 1.1896781646926193 0.9522430370770414 23.99517330916839 -6.693962199765513 1.852570042655932 1.118473099377561 0.9530273718622114 0.3889434599799164 0.08015728170657588 0.40819783712793767 2.719209523316151 0.03457680403194029 0.0895855854402657 2.0231952664034026e-07 6.693962199765513 -0.16544572751534947 TVVSGLVQFVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVVSGLVQFVPK 12 0 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 0 50231000.0 14511000.0 15777000.0 19943000.0 False True 19876108.845030054 15079919.972437855 15232874.13897769 1.0 0.758695783466115 0.7663911612552178 24.24453201168287 -10.697853446780437 6.686681174182734 1.0022658254131032 0.7625434723606666 0.9992129316628288 0.003141624826874794 0.0001070016531227701 4.835002963297917e-06 0.003067165562332959 0.0010139550528764833 2.00514855311463e-11 10.697853446780437 -0.2397223530524366 TVVSGLVQFVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVVSGLVQFVPK 12 0 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 0 43906900.0 26107000.0 7331900.0 10468000.0 False True 21709127.23620034 7292401.599431791 12656810.401436582 1.0 0.3359140844350291 0.5830179289903067 24.37179839120948 -10.26246155049279 5.584770179331122 1.0000410998533524 0.45946600671275023 0.8645000135906267 0.10087972210679132 5.1627943465176954e-05 6.818018530490575e-06 0.0976837708233087 0.03255879030746216 5.4643492540689274e-11 10.26246155049279 -0.5405750931406021 TVVSGLVQFVPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVVSGLVQFVPK 12 0 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 0 51990000.0 11022000.0 24514000.0 16454000.0 False True 14268196.27610143 23149774.350462154 13459540.832297074 1.0 1.6224737803219706 0.9433246201442562 23.76629963126084 -6.665718902827642 1.9534728064208386 1.3987917696893553 0.946167324627995 0.25991708432178806 0.26467974591327775 0.47096873092844554 3.460937206460547 0.10926465562032311 0.2934686769983953 2.15914146163649e-07 6.665718902827642 -0.45262444506136024 TVVSGLVQFVPK(ub)EELQDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVVSGLVQFVPKEELQDR 18 1 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 1 19908400.0 7097900.0 6402400.0 6408100.0 True False 6872581.049694022 8958911.70807494 4729626.371120722 1.0 1.3035730889596135 0.6881877910092151 22.712420585147836 -6.77256748014112 1.564600306405224 1.1735494423534538 0.684383356004199 0.7402942739803848 0.12803397465556146 0.2622974335783764 1.267538301120271 0.0644878957660847 0.15315087544841388 1.6882335234632454e-07 6.77256748014112 -0.48916608634925485 TVVSGLVQFVPK(ub)EELQDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVVSGLVQFVPKEELQDR 18 1 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 1 36777000.0 11146000.0 10914000.0 14717000.0 True False 16909296.881749045 8966311.428528786 11808178.49930974 1.0 0.530259270461241 0.698324630638831 24.011313335413988 -10.052030175608753 5.7037334947219875 1.0000015110939369 0.6142919505499481 0.8753525786888265 0.06861239597900567 1.3184311004108617e-06 2.1920773010317837e-07 0.06643392707007838 0.022144555580794475 8.870943728879668e-11 10.052030175608753 -0.38570956054398875 TVVSGLVQFVPK(ub)EELQDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVVSGLVQFVPKEELQDR 18 1 P54577 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed 1 33764000.0 11146000.0 12152000.0 10466000.0 True False 14428716.720506834 11475730.517533477 8561295.390228586 1.0 0.7953396507690513 0.5933511313629738 23.782439657506437 -6.971287125456428 0.225334359065699 1.087095660649074 0.29585572371026175 0.999990754466915 0.0005047596598348082 0.0758872138383374 0.007518303798061449 0.005373241089702019 0.02024777642653331 1.0683483277068335e-07 6.971287125456428 -0.7912399369388123 TVVSGSCAAHSLLITTEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVVSGSCAAHSLLITTEGK 19 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 115818400.0 24920700.0 40022900.0 50874800.0 False True 32671279.03240209 34051639.328042336 45610763.7215412 1.0 1.042249961939698 1.3960507538228375 24.96151959947676 -6.929254499702162 0.7528765173214296 0.9944686564197984 1.4673266901788433 0.9963899468819951 0.010669746808604677 0.09302628189473705 0.07958707474019568 0.009677985015605062 0.03214495854257425 1.1769160900756572e-07 6.929254499702162 0.4728580337590449 TVVSGSCAAHSLLITTEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVVSGSCAAHSLLITTEGK 19 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 34743300.0 17549200.0 6140100.0 11054000.0 False True 16992110.251946412 8591873.950198501 8158625.787108273 1.0 0.5056390185094474 0.48014199920658585 24.01836169630783 -13.925167540770598 0.4231429944485503 9.999999999999304 0.4793997853503399 0.9998670245086952 0.0027592538233233675 28.512473680852256 0.21720025232336784 236.99518160461034 0.00613999768515218 1.1880438191821753e-14 13.925167540770598 -9.520600214648963 TVVSGSCAAHSLLITTEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVVSGSCAAHSLLITTEGK 19 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 154456500.0 31473900.0 80981000.0 42001600.0 False True 47748207.35030338 66529307.8425591 33699965.350044765 1.0 1.3933362430649743 0.7057849335118681 25.508943234105985 -6.751541075685088 1.6440531423113762 1.2308579162779185 0.704250238064849 0.6555916082252904 0.16529721528815944 0.29737532825395013 1.5818801485336675 0.07940709457288982 0.19247476314799422 1.771980442838011e-07 6.751541075685088 -0.5266076782130695 TVVSGSCAAHSLLITTEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVVSGSCAAHSLLITTEGK 19 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 88228500.0 24920700.0 29396100.0 33911700.0 False True 34134556.246594995 28097283.102096748 25902454.893384658 1.0 0.8231331000501734 0.7588337960587518 25.02472966099965 -13.999999999999998 0.14074839578851875 1.8454381701211766 0.6799729614057304 0.9995999640248079 0.0020394455148501434 11.934857546898819 0.11759687205265712 2.7700999257875947 0.07053676064562468 1.0000000000000041e-14 13.999999999999998 -1.1654652087154462 TVVSGSCAAHSLLITTEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVVSGSCAAHSLLITTEGK 19 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 32346400.0 17549200.0 3988600.0 10808600.0 False True 14592937.3613792 3967112.620124888 13068628.286680115 1.0 0.2718515485870591 0.8955447394207809 23.798766971742108 -10.54943907880913 8.917264615915549 1.0000399610956596 0.5836981440041744 0.3726619514868026 0.2546216789318188 0.00020230581799413102 1.0221786575314118e-05 0.2465598813911844 0.08217879350719219 2.8220254184022307e-11 10.54943907880913 -0.4163418170914852 TVVSGSCAAHSLLITTEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVVSGSCAAHSLLITTEGK 19 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 97262500.0 31473900.0 40310900.0 25477700.0 False True 40743583.99332138 38067562.978870995 20841020.023277927 1.0 0.9343204315337346 0.51151661146683 25.280069556198434 -6.934365663333735 0.7100515107559545 1.0055072678849777 0.41421039088709455 0.9973286753167209 0.01118768343074996 0.09043387062009503 0.06703625806229788 0.010471434707592707 0.0373809170331311 1.163146281639158e-07 6.934365663333735 -0.5912968769978831 TVVSHSLTTLGLEVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVVSHSLTTLGLEVAK 16 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 0 12175100.0 2979900.0 6419200.0 2776000.0 False True 3906677.757392652 5461480.38184562 2488766.1492722966 1.0 1.397985890059859 0.6370543730060089 21.89751082894491 -6.764545168719699 1.5950523981002869 1.2298538764413471 0.6335994478399817 0.7093953567570557 0.16752308275261826 0.27532833678088436 1.3814717810952208 0.08282397544318161 0.19818088285095978 1.7197084739654716e-07 6.764545168719699 -0.5962544286013655 TVVSHSLTTLGLEVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVVSHSLTTLGLEVAK 16 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 0 9784300.0 6396100.0 3388200.0 0.0 False True 6193059.306548132 4741125.92922958 0.0 1.0 0.7655547435524518 0.0 22.56222083111564 -7.307073368383359 0.8140604862041332 0.9890227860879139 6.781922463297194e-19 0.9882150404150475 0.04635559872245314 0.10463891242778371 0.13750319635344974 0.03956295504553531 0.07007301627976399 4.930904957158551e-08 7.307073368383359 -0.9890227860879139 down TVVSHSLTTLGLEVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVVSHSLTTLGLEVAK 16 0 P42166 P42166 TMPO Lamina-associated polypeptide 2, isoform alpha;Thymopoietin;Thymopentin 0 13928200.0 2979900.0 3738200.0 7210100.0 False True 4081649.558769556 3573033.9634256964 5507222.876670671 1.0 0.8753896952639938 1.3492640162696536 21.9607208904678 -6.836818229756486 1.297128850651614 0.933659737984072 1.363889988000971 0.9188372028745981 0.05714174372403075 0.17254833905592085 0.5653253152805348 0.034560370466743165 0.07956370596180631 1.4560683780396572e-07 6.836818229756486 0.43023025001689896 TVVTGIEMFHK ddPTM_RPMI8226_Bortezomib_1h_R1 2 TVVTGIEMFHK 11 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 99414200.0 32430600.0 29914500.0 37069100.0 False True 42516830.65837711 25451373.20580773 33233545.123915605 1.0 0.598618777827294 0.7816562196497491 25.341530721949358 -10.045659044094203 4.723959465390439 1.000008764982255 0.6901374987291765 0.792581674722106 0.07472472274395049 103470019.12570667 8.623261421560441 10820.24836342144 0.025580260151979974 9.002040363542878e-11 10.045659044094203 -0.3098712662530786 TVVTGIEMFHK ddPTM_RPMI8226_Bortezomib_2h_R1 2 TVVTGIEMFHK 11 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 66017720.0 20331100.0 10440720.0 35245900.0 False True 19685700.35918149 14609753.94363552 26013941.43566484 1.0 0.7421505802216212 1.3214638524929 24.23064470445775 -6.78569998100773 1.513333481508133 0.8550753471442047 1.3269265880692 0.7871137784380909 0.10934091042955495 0.24183388229163946 1.0941371663519401 0.05688370112171378 0.13361544246893284 1.6379476564645625e-07 6.78569998100773 0.4718512409249953 TVVTGIEMFHK ddPTM_RPMI8226_Bortezomib_8h_R1 2 TVVTGIEMFHK 11 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 133173600.0 28667700.0 79048000.0 25457900.0 False True 43490996.7896032 64941266.79515709 20426134.906406052 1.0 1.4932117355075594 0.4696635261137323 25.374213439165217 -6.775690850688176 1.5527547350441417 1.2808370837111263 0.4626393618109292 0.7517962341496475 0.2082246128304906 0.2573379126650511 1.225185456770105 0.10565614803553608 0.2502072867927957 1.6761355961771333e-07 6.775690850688176 -0.818197721900197 down TVVTGIEMFHK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TVVTGIEMFHK 11 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 95312500.0 32430600.0 21925100.0 40956800.0 False True 44421069.22401147 20956376.585389953 31283647.37177366 1.0 0.4717665952548063 0.704252462137123 25.40474078347225 -10.330139272256961 5.810493195232511 1.00005280389652 0.5880095286959649 0.8072164265010222 0.09491195771171987 6.493164115977202e-05 7.485777183863209e-06 0.0919098391237862 0.030632702631118766 4.675851691197825e-11 10.330139272256961 -0.41204327520055506 TVVTGIEMFHK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TVVTGIEMFHK 11 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 46007240.0 20331100.0 15647040.0 10029100.0 False True 16906210.47044519 15562746.289825724 12126138.440680891 1.0 0.920534280407306 0.7172594036895115 24.011049979892025 -6.9549680816383805 0.5013460403222453 1.0040238955506116 0.6249822811217525 0.9995356809166589 0.002565507759163526 0.08155003674868977 0.028165105503878685 0.0030011172347171795 0.016769148346008685 1.1092563367767852e-07 6.9549680816383805 -0.3790416144288591 TVVTGIEMFHK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TVVTGIEMFHK 11 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 93843800.0 28667700.0 39063100.0 26113000.0 False True 37110902.77484962 36889204.14577534 21360701.942006443 1.0 0.9940260513084438 0.5755910081627756 25.145339761257667 -6.910009095001674 0.8956746561363803 1.0129518444776808 0.5215051088594097 0.990924959567426 0.018926397351655633 0.10441195553672557 0.13873529910000257 0.015495992546218989 0.04277854882947339 1.2302430067747676e-07 6.910009095001674 -0.4914467356182711 TVWDWELMNDIKPIWQRPSK ddPTM_RPMI8226_Bortezomib_1h_R1 2 TVWDWELMNDIKPIWQRPSK 20 2 P14625 P14625 HSP90B1 Endoplasmin 0 51391240.0 15241100.0 20193370.0 15956770.0 False True 19981229.695022374 17180597.909139737 14305716.508546025 1.0 0.8598368654667777 0.715957762705155 24.25214203714762 -6.970797855218508 0.23836022994417194 1.0527249637494236 0.5189165896573469 0.9999879518927972 0.0004024708389209943 0.0760446580460151 0.008098065325597228 0.0034795422775670457 0.014068048837414108 1.0695525925834017e-07 6.970797855218508 -0.5338083740920767 TVWDWELMNDIKPIWQRPSK ddPTM_RPMI8226_Bortezomib_2h_R1 2 TVWDWELMNDIKPIWQRPSK 20 2 P14625 P14625 HSP90B1 Endoplasmin 0 703425500.0 276901800.0 125405000.0 301118700.0 False True 268111703.9273825 175479870.47843572 222246679.10263452 1.0 0.6545028356015524 0.8289331493071618 27.998258958014457 -10.11884482688925 5.20547284168941 1.000006687515679 0.7417179924540749 0.7451167878855867 0.07121087737637535 5.526904538248414e-06 9.356054108119869e-07 0.06895141976283738 0.0229832118454849 7.605979895188186e-11 10.11884482688925 -0.2582886950616041 TVWDWELMNDIKPIWQRPSK ddPTM_RPMI8226_Bortezomib_8h_R1 2 TVWDWELMNDIKPIWQRPSK 20 2 P14625 P14625 HSP90B1 Endoplasmin 0 465517600.0 147501300.0 164327000.0 153689300.0 False True 223770255.88946122 135001562.95728874 123312542.49058668 1.0 0.6033043239847626 0.5510676206738622 27.73744304146947 -13.999999999999998 0.2857642457055018 4.338060572244405 0.5362155253452349 0.9996179934993091 0.003917867348633819 15.71875279376216 0.16943675336168235 30.76948541728905 0.02011349523431448 1.0000000000000041e-14 13.999999999999998 -3.8018450468991705 TVWDWELMNDIKPIWQRPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TVWDWELMNDIKPIWQRPSK 20 2 P14625 P14625 HSP90B1 Endoplasmin 0 91344600.0 15241100.0 21423700.0 54679800.0 False True 20876146.54524068 20477130.095297996 41765557.40583027 1.0 0.9808864893203362 2.0006353814062456 24.315352098670513 -6.902631701657526 0.9445018108413074 0.9606093683099869 2.113576617573507 0.9878301409704521 0.052541055468817856 0.10949335099677039 0.16670495700680965 0.04150679471099264 0.10948907849588799 1.2513197474275276e-07 6.902631701657526 1.1529672492635203 up TVWDWELMNDIKPIWQRPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TVWDWELMNDIKPIWQRPSK 20 2 P14625 P14625 HSP90B1 Endoplasmin 0 570705980.0 276901800.0 148586500.0 145217680.0 False True 230256115.52966267 147786035.032389 175582025.47731066 1.0 0.641833267674276 0.7625509753494099 27.778664233448733 -10.927156744654342 11.14691008167132 1.045915462726666 0.702192121511843 0.8902863691486699 0.04928279778708977 0.02719641172854155 0.00017772388493986685 0.02307712960249499 0.015905954590325528 1.1826146518891961e-11 10.927156744654342 -0.34372334121482306 TVWDWELMNDIKPIWQRPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TVWDWELMNDIKPIWQRPSK 20 2 P14625 P14625 HSP90B1 Endoplasmin 0 339254800.0 147501300.0 109237500.0 82516000.0 False True 190943340.53530398 103158337.09752019 67498934.68565848 1.0 0.5402562708304928 0.3535024290264705 27.508569363561918 -13.99999999999703 0.12399700158965982 3.1863580130357008 0.0708742427714313 0.9996735764867978 0.004908160202779709 11.950183488977014 0.1088665737548534 6.406788559188769 0.2509273647585944 1.0000000000068388e-14 13.99999999999703 -3.1154837702642695 TVWIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVWIAR 6 0 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 15010500.0 4866400.0 6785100.0 3359000.0 False True 6379897.526284639 5772789.528112656 3011442.901803189 1.0 0.9048404781313887 0.4720205754710477 22.605101820977602 -6.941937129921678 0.6412891543397399 1.0047426240521458 0.34833624920863365 0.9984067754955523 0.009171340626205445 0.08689392559543706 0.050667973858599905 0.009064546225886028 0.036945680223159194 1.1430437940679995e-07 6.941937129921678 -0.656406374843512 down TVWIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVWIAR 6 0 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 12772400.0 6669300.0 2395700.0 3707400.0 False True 6457586.722090249 3352315.503410459 2736320.7203840455 1.0 0.5191282204453852 0.42373735547733055 22.622563682454818 -13.999999999999975 0.22741669262121142 3.9997587768942067 0.37620260893957896 0.9995063765870327 0.0056031489357553045 13.212136032704457 0.15101472616320716 17.87037858623061 0.050324560894808724 1.0000000000000573e-14 13.999999999999975 -3.6235561679546278 TVWIAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVWIAR 6 0 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 35166300.0 8159000.0 19713000.0 7294300.0 False True 12377799.502798377 16195061.131627992 5852578.40779474 1.0 1.3083958201105623 0.47282866445458155 23.561251522497617 -6.8067814268917886 1.4279716950673722 1.1687231203916892 0.4592557611905252 0.8512717057589156 0.1330481415533046 0.21122081168987905 0.8494475018834163 0.07327435917368687 0.16976291690825365 1.560337596916794e-07 6.8067814268917886 -0.709467359201164 down TVWIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVWIAR 6 0 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 16520400.0 4866400.0 5926700.0 5727300.0 False True 6665639.589515139 5664838.79702398 4374629.697446065 1.0 0.8498567498210688 0.6562955645437585 22.668311882500493 -6.96765234705407 0.3091743977695785 1.030111940263591 0.46989507561605487 0.9999578385532985 0.0009135042668530094 0.07707217464022667 0.011743596512774727 0.0030740192393827717 0.017198329894038068 1.0773272695537721e-07 6.96765234705407 -0.5602168646475361 TVWSSGDDK(ub)EQLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVWSSGDDKEQLVK 14 1 K7EM91;O43291;K7ES27;O43291-2 K7EM91 SPINT2 Kunitz-type protease inhibitor 2 1 123921500.0 37973300.0 47166500.0 38781700.0 True False 49783364.03396033 40129442.053577036 34768941.70433482 1.0 0.8060813653774431 0.6984048261707819 25.569160385714333 -13.999999999995433 0.06996958822394057 2.1226213330845782 0.3073805820962317 0.9999245169594454 0.001084193319612201 12.360617993300009 0.07137964546421706 2.2654759565988205 0.36018617473446807 1.000000000010516e-14 13.999999999995433 -1.8152407509883466 TVWSSGDDK(ub)EQLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVWSSGDDKEQLVK 14 1 K7EM91;O43291;K7ES27;O43291-2 K7EM91 SPINT2 Kunitz-type protease inhibitor 2 1 49372900.0 14666900.0 14544200.0 20161800.0 True False 14201307.287755176 20351774.907001026 14880819.738965051 1.0 1.4330916509742015 1.0478485844606553 23.75952040596621 -10.446929579875638 6.508523710347502 0.9999395509935214 1.2404701177174284 0.3418917601449455 0.15727482331721152 0.00013798820922897442 1.1725558428134347e-05 0.1523188464862 0.05076023095710618 3.573307740424673e-11 10.446929579875638 0.24053056672390705 TVWSSGDDK(ub)EQLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVWSSGDDKEQLVK 14 1 K7EM91;O43291;K7ES27;O43291-2 K7EM91 SPINT2 Kunitz-type protease inhibitor 2 1 111868700.0 49936500.0 37661000.0 24271200.0 True False 75757321.3471615 30940100.303263966 19473986.681555133 1.0 0.4084106955350163 0.25705748745147244 26.174881984623347 -13.999999999999893 0.1914065818815605 4.186836692329887 0.14999861057670485 0.9994886958381947 0.007248593609680672 12.373963456450985 0.1387413919246746 14.714399678923055 0.1029351508921368 1.0000000000002453e-14 13.999999999999893 -4.036838081753182 TVWSSGDDK(ub)EQLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVWSSGDDKEQLVK 14 1 K7EM91;O43291;K7ES27;O43291-2 K7EM91 SPINT2 Kunitz-type protease inhibitor 2 1 85750400.0 37973300.0 25439300.0 22337800.0 True False 52013055.199846976 24315307.609484572 17062071.70143189 1.0 0.4674847019860527 0.32803440666723394 25.632370447237225 -13.999999999999972 0.18810088386477244 3.836125625751216 0.22605704079875444 0.9994905651441884 0.006535349831162728 12.32041312040401 0.137533703919192 12.799120492289516 0.09737024306422895 1.0000000000000655e-14 13.999999999999972 -3.6100685849524616 TVWSSGDDK(ub)EQLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVWSSGDDKEQLVK 14 1 K7EM91;O43291;K7ES27;O43291-2 K7EM91 SPINT2 Kunitz-type protease inhibitor 2 1 49479500.0 14666900.0 23820900.0 10991700.0 True False 12196177.203839084 23692572.083621528 13290013.650121352 1.0 1.9426228143162463 1.0896868279298166 23.539925681400486 -10.288762134362614 4.143204281001736 0.9994172119661855 1.5161548211440385 0.3280818516632764 0.3482096583869594 246914005.5667523 1313.0242368388676 1374274.4659562202 0.11920142788977214 5.1432527342416354e-11 10.288762134362614 0.516737609177853 TVWSSGDDK(ub)EQLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVWSSGDDKEQLVK 14 1 K7EM91;O43291;K7ES27;O43291-2 K7EM91 SPINT2 Kunitz-type protease inhibitor 2 1 101140600.0 49936500.0 32721800.0 18482300.0 True False 64643783.64557601 30900803.065226037 15118711.04441255 1.0 0.47801662159267466 0.23387726076345194 25.946008306715797 -9.880311610367537 0.19293794677412632 1.607402837288621 1.1525583613655852e-08 0.9994860248312141 0.007244541617890034 1.3639185991439107 0.08548150539668256 0.5918365940189786 0.1499066512656611 1.3173112162230078e-10 9.880311610367537 -1.6074028257630375 TVWSSGDDK(ub)EQLVK(ub)NTYVL ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVWSSGDDKEQLVKNTYVL 19 2 K7EM91;O43291;K7ES27;O43291-2 K7EM91 SPINT2 Kunitz-type protease inhibitor 2 2 46552000.0 10842000.0 17466000.0 18244000.0 True False 14213966.99407735 14860140.881934771 16356285.888805388 1.0 1.0454604888365555 1.1507192816488667 23.760805918578715 -6.957084961262557 0.47475169011445917 0.997344397249727 1.2031850482013071 0.999646275356369 0.0011872051511776834 0.08075960599606576 0.02510877958324711 0.0014686858754489993 0.008684973939323236 1.1038626495350516e-07 6.957084961262557 0.2058406509515801 TVWSSGDDK(ub)EQLVK(ub)NTYVL ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVWSSGDDKEQLVKNTYVL 19 2 K7EM91;O43291;K7ES27;O43291-2 K7EM91 SPINT2 Kunitz-type protease inhibitor 2 2 43958000.0 10842000.0 14363000.0 18753000.0 True False 14850580.394033186 13728395.167910561 14323927.630158382 1.0 0.9244349246731456 0.9645365534611423 23.824015980101606 -10.284031803841613 4.742850331805508 1.0000223189665456 0.9444857390670481 0.7187213524814209 0.01637142139784928 3.8652359589247525e-06 5.834839427200554e-07 0.015857932816187425 0.0052838535355872445 5.1995791807414345e-11 10.284031803841613 -0.05553657989949745 TVWSSGDDK(ub)EQLVK(ub)NTYVL ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVWSSGDDKEQLVKNTYVL 19 2 K7EM91;O43291;K7ES27;O43291-2 K7EM91 SPINT2 Kunitz-type protease inhibitor 2 2 67557000.0 32003000.0 21518000.0 14036000.0 True False 41428514.373441644 20320504.384157818 11481592.021521935 1.0 0.49049560891772104 0.27714225805988296 25.30412075041093 -12.153440296316566 0.14372602317625116 2.464025863588604 2.018157821133094e-14 0.9996319131388997 0.005818001377563249 5.822120250411251 0.10015670155801631 2.751166351331127 0.2188937908777932 7.023598924882837e-13 12.153440296316566 -2.464025863588584 TVWSSGDDKEQLVK(ub)NTYVL ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVWSSGDDKEQLVKNTYVL 19 2 K7EM91;O43291;K7ES27;O43291-2 K7EM91 SPINT2 Kunitz-type protease inhibitor 2 1 88494000.0 22136000.0 38284000.0 28074000.0 True False 29020510.36532894 32572176.429863177 25169171.78482365 1.0 1.1223846865483607 0.8672890816866363 24.790569555602914 -6.7762467080524535 1.550490082421139 1.069635163963035 0.8655009921015928 0.7538863070160622 0.051678965583514834 0.2564500941956002 1.217434777430736 0.026259311273643813 0.062158270899865274 1.6739916676513894e-07 6.7762467080524535 -0.20413417186144223 TVWSSGDDKEQLVK(ub)NTYVL ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVWSSGDDKEQLVKNTYVL 19 2 K7EM91;O43291;K7ES27;O43291-2 K7EM91 SPINT2 Kunitz-type protease inhibitor 2 1 91376000.0 27122000.0 25226000.0 39028000.0 True False 26261026.95583218 35298873.35185213 28805395.98509696 1.0 1.3441543398596139 1.0968876439426416 24.64641999914442 -10.179306784978086 3.7974709167819936 0.9998329351971753 1.2205209918744508 0.51467899176925 0.10094620637806705 30397356.36886679 37034448.68866232 56070.233883148765 0.036942527759208484 6.617488801291623e-11 10.179306784978086 0.22068805667727553 TVWSSGDDKEQLVK(ub)NTYVL ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVWSSGDDKEQLVKNTYVL 19 2 K7EM91;O43291;K7ES27;O43291-2 K7EM91 SPINT2 Kunitz-type protease inhibitor 2 1 166463000.0 61750000.0 58109000.0 46604000.0 True False 93679264.52969708 47738994.9423107 37392698.972741194 1.0 0.5096004455412548 0.3991566240455209 26.481226413582647 -13.999999999999998 0.2094630873503543 3.8299149158840087 0.33376568634303677 0.9994897171400995 0.005898789675638822 12.7341776293697 0.14506641687091618 14.826984957087559 0.06566844239321777 1.0000000000000041e-14 13.999999999999998 -3.496149229540972 TVWSSGDDKEQLVK(ub)NTYVL ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVWSSGDDKEQLVKNTYVL 19 2 K7EM91;O43291;K7ES27;O43291-2 K7EM91 SPINT2 Kunitz-type protease inhibitor 2 1 84514000.0 22136000.0 28325000.0 34053000.0 True False 30320277.4029071 27073507.841750816 26010382.743549462 1.0 0.8929175509177569 0.8578543790320201 24.853779617125806 -13.999999999995755 0.1560877649528076 1.52324207356339 0.8218531254624423 0.9995472002528526 0.0012865747120512233 11.985871113537007 0.1247069869779206 1.8995451722590149 0.032658363697202354 1.0000000000097756e-14 13.999999999995755 -0.7013889481009478 TVWSSGDDKEQLVK(ub)NTYVL ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVWSSGDDKEQLVKNTYVL 19 2 K7EM91;O43291;K7ES27;O43291-2 K7EM91 SPINT2 Kunitz-type protease inhibitor 2 1 101380000.0 27122000.0 35133000.0 39125000.0 True False 22553144.70832438 34943731.555645466 47305856.60643924 1.0 1.5493950847017672 2.0975281814681312 24.426825274578697 -6.9711536719761 0.22896058372103636 0.7741580050110025 2.8884075711549158 0.9999900359155557 0.0014143445861235285 0.07593009058288683 0.007677229250718092 0.014192575380215913 0.05455095799500323 1.0686766687668363e-07 6.9711536719761 2.114249566143913 TVWSSGDDKEQLVK(ub)NTYVL ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVWSSGDDKEQLVKNTYVL 19 2 K7EM91;O43291;K7ES27;O43291-2 K7EM91 SPINT2 Kunitz-type protease inhibitor 2 1 155604000.0 61750000.0 49422000.0 44432000.0 True False 79936592.27447487 46671622.25457039 36345831.910819456 1.0 0.5838580420630896 0.4546832792924212 26.252352735675096 -13.999999999999998 0.16381005026838175 3.0668040995503376 0.33288912307200363 0.9995268693673537 0.0050609991332510465 12.037226923727887 0.1280202156224505 7.903278617179013 0.1115594073150023 1.0000000000000041e-14 13.999999999999998 -2.733914976478334 TVYCNVHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVYCNVHK 8 0 Q13263;Q13263-2;M0R3C0;M0R2I3 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 7650200.0 1743500.0 3327300.0 2579400.0 False True 2285745.3840780193 2830879.809713819 2312508.431351934 1.0 1.238493066390107 1.0117086738795755 21.124233275769665 -10.95901482531872 2.5861885412982963 0.9020016094483563 1.125100869646169 0.28862389140889066 0.0925843426342655 20119148.64877327 7621490.5701183975 11807456.038141735 0.03663577695410888 1.0989683237964002e-11 10.95901482531872 0.2230992601978128 TVYCNVHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVYCNVHK 8 0 Q13263;Q13263-2;M0R3C0;M0R2I3 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 2780970.0 1242600.0 870030.0 668340.0 False True 1203154.3431648507 1217437.5161465136 493281.70422977547 1.0 1.0118714386585612 0.40999037823544493 20.198390295658296 -6.902401892786959 0.945958902942209 1.023401674668162 0.34363851466448075 0.9877238444458838 0.03113120797538429 0.10965881097644975 0.16761655297536027 0.02456645745849222 0.06472345744980743 1.251982064095759e-07 6.902401892786959 -0.6797631600036813 down TVYCNVHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVYCNVHK 8 0 Q13263;Q13263-2;M0R3C0;M0R2I3 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 6419400.0 1743500.0 2332100.0 2343800.0 False True 2388119.0663158908 2229060.1107765953 1790242.712076215 1.0 0.9333957180850815 0.7496455002295974 21.187443337292557 -6.95331790861204 0.5211465420768666 1.003094960664426 0.6717300265064123 0.9994365971769011 0.002512954262172986 0.08218015189533881 0.030655415678402523 0.0028416880503549227 0.015179610799315325 1.1134791555022933e-07 6.95331790861204 -0.3313649341580136 TVYFAEEVQCEGNSFHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVYFAEEVQCEGNSFHK 17 0 P21291;E9PS42 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 17090900.0 3300900.0 7198900.0 6591100.0 False True 4327511.865961077 6124852.1810924215 5909116.198295626 1.0 1.415328801122116 1.3654766021036198 22.045106344765824 -10.104264313526615 4.610960566167494 0.9999710725069156 1.3904027016221217 0.9879183743697452 0.020352075056772743 6.052634856418275e-06 1.1758246897336653e-06 0.019707270086129134 0.006568603975177429 7.865669359063411e-11 10.104264313526615 0.390431629115206 TVYFAEEVQCEGNSFHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVYFAEEVQCEGNSFHK 17 0 P21291;E9PS42 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 48065300.0 5970200.0 34940000.0 7155100.0 False True 9057229.880084181 28704684.01253398 5740891.3488082625 1.0 3.1692564274704256 0.6338462669951471 23.110638444170654 -6.680163314014252 1.9011992784499727 2.3723006216017892 0.6434585916327439 0.32492322627927595 0.9193473894820713 0.43815833246095787 3.0621366270534236 0.38798537444319703 1.0231117518607915 2.0885106104179327e-07 6.680163314014252 -1.7288420299690452 TVYFAEEVQCEGNSFHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVYFAEEVQCEGNSFHK 17 0 P21291;E9PS42 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 16006800.0 3300900.0 7917600.0 4788300.0 False True 4521331.933468384 7567774.251998099 3657402.1581340255 1.0 1.6737931130379853 0.8089214001433369 22.108316406288715 -6.698823480322987 1.8352558572262159 1.4188851461102925 0.8115665099556333 0.41191255009636074 0.2844786526816362 0.39797272280177654 2.6052222345545144 0.12370603749422196 0.3185796146544469 2.000674881857118e-07 6.698823480322987 -0.6073186361546592 TVYFAEEVQCEGNSFHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVYFAEEVQCEGNSFHK 17 0 P21291;E9PS42 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 5607740.0 3256700.0 815840.0 1535200.0 False True 2708090.3462724052 811444.9079884385 1856203.2220372013 1.0 0.29963731051490394 0.6854288390312392 21.36884443967908 -10.730386119734995 6.914650274213348 1.0069362070837615 0.4925330747740712 0.697611735774504 0.15749873199223452 0.016865486809927742 0.0006576129488912426 0.15271805451701273 0.05083249717122578 1.8604323399764645e-11 10.730386119734995 -0.5144031323096903 TVYFAEEVQCEGNSFHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVYFAEEVQCEGNSFHK 17 0 P21291;E9PS42 P21291 CSRP1 Cysteine and glycine-rich protein 1 0 20351600.0 5970200.0 6860800.0 7520600.0 False True 7728541.59023596 6478990.4488721 6151927.967872457 1.0 0.8383199305102387 0.7960011466645459 22.881764766263103 -13.999999997625318 0.18816975567224492 1.8612933752663803 0.7650757515084216 0.9994905152299914 0.0019841808928745463 12.32151518178596 0.13755927360327136 3.8887777820813696 0.029532463538564483 1.0000000054679068e-14 13.999999997625318 -1.0962176237579588 TVYGGGCSEMLMAHAVTQLANR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TVYGGGCSEMLMAHAVTQLANR 22 0 P78371;F5GWF6;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 0 31833900.0 6977800.0 15240500.0 9615600.0 False True 9147963.373111332 12966676.807003692 8620669.951348241 1.0 1.417438644880972 0.9423594738788562 23.125019158779878 -6.6746764182934175 1.9210292617122073 1.2653778024083602 0.9442465895526317 0.29978804152788807 0.1771314163355181 0.4504890882182049 3.2094365480424165 0.07411903747028077 0.19681104905404664 2.1150643332269014e-07 6.6746764182934175 -0.32113121285572843 TVYGGGCSEMLMAHAVTQLANR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVYGGGCSEMLMAHAVTQLANR 22 0 P78371;F5GWF6;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 0 21081600.0 11697000.0 3758900.0 5625700.0 False True 11325685.137614084 5259848.372404547 4152160.402617609 1.0 0.4644176761488717 0.366614500771149 23.433094991722783 -13.999999999999979 0.2391440750146916 4.5303975260079685 0.32301834328403006 0.9995235534357894 0.006076956220742808 13.593381624412373 0.15478161819887662 22.906459435423784 0.048031989929264 1.000000000000049e-14 13.999999999999979 -4.207379182723939 TVYGGGCSEMLMAHAVTQLANR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVYGGGCSEMLMAHAVTQLANR 22 0 P78371;F5GWF6;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 0 72286000.0 11620000.0 46637000.0 14029000.0 False True 17628389.535790805 38314262.97345582 11256162.000870872 1.0 2.1734409088060267 0.6385246921176526 24.071397345627776 -6.702366186918948 1.8222054558794896 1.7269374802454514 0.6428419701940765 0.4289786523453464 0.4951089280576095 0.39058847311708433 2.5229599258646496 0.21661979344435198 0.555514228509041 1.98442099452062e-07 6.702366186918948 -1.084095510051375 TVYGGGCSEMLMAHAVTQLANR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TVYGGGCSEMLMAHAVTQLANR 22 0 P78371;F5GWF6;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 0 38950800.0 7335000.0 16049500.0 15566300.0 False True 10046947.720921727 15340380.02140086 11889860.53801177 1.0 1.5268696968987017 1.1834301191049665 23.260253939076602 -10.204072364472646 5.013963891852521 0.9999637276938084 1.3551499080005387 0.587766454105531 0.14020862051321226 5.686729992573778e-05 9.027217126774153e-06 0.1357702552857748 0.04525213768668105 6.250685318313733e-11 10.204072364472646 0.3551861803067303 TVYGGGCSEMLMAHAVTQLANR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVYGGGCSEMLMAHAVTQLANR 22 0 P78371;F5GWF6;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 0 16870200.0 11697000.0 0.0 5173200.0 False True 9726573.764960935 0.0 6254892.201825726 1.0 0.0 0.6430725097010404 23.21350026715706 -10.27071664712858 7.385624891644106 1.0000027881321951 0.32153625485052023 0.5974446856032232 0.2625332527297557 1.2052807764095491e-05 1.1898559327347156e-06 0.254197773776668 0.08473224297066721 5.3614634894480127e-11 10.27071664712858 -0.6784665332816748 TVYGGGCSEMLMAHAVTQLANR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVYGGGCSEMLMAHAVTQLANR 22 0 P78371;F5GWF6;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 0 42298000.0 11620000.0 16350000.0 14328000.0 False True 15042319.064443724 15440108.127194917 11720451.017694931 1.0 1.026444663289417 0.7791651651239829 23.842523667720226 -6.880438456416968 1.0773148360723535 1.0164882171776055 0.761490069586608 0.9740389132415916 0.017862661871001825 0.1272440578917718 0.26992548264462085 0.012767105646105687 0.030909735265246943 1.3169265202831713e-07 6.880438456416968 -0.2549981475909975 TVYSILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVYSILR 7 0 P05198;H0YJS4;G3V4T5 P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 0 18974200.0 4870600.0 9344200.0 4759400.0 False True 7389056.288556157 7676654.5034321705 3818702.503880878 1.0 1.0389221848697288 0.5168051716962984 22.816958688126014 -6.888944452392898 1.0286300754811182 1.0287680855395818 0.472819936503984 0.9802131818426654 0.03340618045592542 0.12000280831775872 0.22689536947409136 0.024779358699546502 0.061543863890068336 1.2913844351132716e-07 6.888944452392898 -0.5559481490355977 TVYSILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVYSILR 7 0 P05198;H0YJS4;G3V4T5 P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 0 13496400.0 4870600.0 5272400.0 3353400.0 False True 6305087.713879473 4978986.305187918 2743115.60878966 1.0 0.7896775637597571 0.43506382992122433 22.588085010218464 -6.963241560819302 0.3870471441521705 1.022508557705296 0.18955126198898842 0.9998721824143166 0.00263565941352779 0.07856284667072637 0.016996153020996746 0.004586988736157056 0.029867595364631166 1.088324583210865e-07 6.963241560819302 -0.8329572957163075 down TVYSVFGFSFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TVYSVFGFSFK 11 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 10565390.0 3519590.0 4124200.0 2921600.0 False True 4614216.57375805 3508885.436005691 2619300.857966119 1.0 0.7604509627834565 0.5676588465445237 22.13765428954663 -6.973588692557851 0.14935763850220185 1.2261402193894284 0.09690174702551144 0.9999985709733602 0.00021132653768864558 0.07515452473418655 0.0045624663304808 0.00990261078618844 0.02411391891298848 1.0627015339089412e-07 6.973588692557851 -1.129238472363917 TVYSVFGFSFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TVYSVFGFSFK 11 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 44153000.0 18689000.0 12925000.0 12539000.0 False True 18095727.924841393 18086019.9029846 9254659.73806321 1.0 0.9994635185775829 0.5114278782539955 24.10914580742551 -6.907136936471782 0.9150154765205195 1.016512564022957 0.4520732904378647 0.9897954263281485 0.02325313619035685 0.10634174933090965 0.14926407723298002 0.018772160308492745 0.050846880414236004 1.2384060457801605e-07 6.907136936471782 -0.5644392735850924 TVYSVFGFSFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TVYSVFGFSFK 11 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 154693000.0 50091000.0 49885000.0 54717000.0 False True 75991709.14262444 40982631.99671604 43902160.96668694 1.0 0.5393039906471653 0.5777230366577164 26.179338690250763 -10.568486814353516 5.89871331773733 1.0012576066919183 0.5585135136524408 0.9943524511660812 0.01568450985506013 0.0002600656840059773 1.9024773017512024e-05 0.01522526187895253 0.0050621537885061465 2.7009291101858e-11 10.568486814353516 -0.4427440930394775 TVYSVFGFSFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TVYSVFGFSFK 11 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 15187390.0 3519590.0 4213400.0 7454400.0 False True 4820877.536343418 4027238.0561494385 5693824.248187102 1.0 0.8353744781503107 1.181076309294885 22.200864351069523 -6.777220726954807 1.5467923751254269 0.9064479140842677 1.1835753436314667 0.757397983382501 0.06954038715318278 0.254918511977193 1.2044980300549455 0.03541756791451076 0.08376359816025258 1.6702415106727344e-07 6.777220726954807 0.27712742954719893 TVYSVFGFSFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TVYSVFGFSFK 11 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 35997800.0 18689000.0 6389800.0 10919000.0 False True 15540731.563080708 6355376.879124003 13202112.41624817 1.0 0.408949659372673 0.8495167915783147 23.889551082859786 -9.82239850905474 6.267527781232279 1.000000015433014 0.6292332254753595 0.485679630936555 0.17986077855809285 3.8836675103186696e-08 7.452783389797104e-09 0.17414945778267407 0.05804981666586523 1.5052252361041406e-10 9.82239850905474 -0.37076678995765444 TVYSVFGFSFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TVYSVFGFSFK 11 0 P26639;P26639-2 P26639 TARS Threonine--tRNA ligase, cytoplasmic 0 126694000.0 50091000.0 42242000.0 34361000.0 False True 64843786.94122629 39891195.56629764 28107650.573633194 1.0 0.6151891715154544 0.43346713539586557 25.950465012343212 -13.999999999961066 0.09985843852030019 2.901195111128265 0.04556775137911369 0.9997944263319255 0.0033864169432138726 12.081478439174438 0.09407941782579528 4.735111213750128 0.34598214196181076 1.0000000000896493e-14 13.999999999961066 -2.855627359749151 TWEILK(ub)EDESGSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TWEILKEDESGSLK 14 1 Q6P1K8;Q13888;D6RJD3;D6RID8;D6RIT7;D6RGC9;D6RAW1 Q6P1K8 GTF2H2C;GTF2H2 General transcription factor IIH subunit 2-like protein;General transcription factor IIH subunit 2 1 28207000.0 0.0 9936000.0 18271000.0 True False 0.0 8162843.169677662 14659728.841536231 0.0 TWEILK(ub)EDESGSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TWEILKEDESGSLK 14 1 Q6P1K8;Q13888;D6RJD3;D6RID8;D6RIT7;D6RGC9;D6RAW1 Q6P1K8 GTF2H2C;GTF2H2 General transcription factor IIH subunit 2-like protein;General transcription factor IIH subunit 2 1 34538000.0 0.0 8356000.0 26182000.0 True False 0.0 7890981.254485673 21417144.65000623 0.0 TWEQQQEVVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TWEQQQEVVSR 11 0 Q9UJU6;H0Y5J4;Q9UJU6-5;Q9UJU6-2;Q9UJU6-3;B4DDD6;Q9UJU6-6;Q9UJU6-4 Q9UJU6;Q9UJU6-2 DBNL Drebrin-like protein 0 7805000.0 1759500.0 3162000.0 2883500.0 False True 2306721.5390222385 2690241.925379466 2585143.080485114 1.0 1.1662621083079634 1.120700109117155 21.137412425742625 -10.127394433225346 4.441331766519437 0.999981338607963 1.1434811086560923 0.929690231154618 0.018600608302427248 12982748.940993372 0.10775238209204895 2537.219513031675 0.0063674829657110925 7.457711294194277e-11 10.127394433225346 0.1434997700481293 TWEQQQEVVSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TWEQQQEVVSR 11 0 Q9UJU6;H0Y5J4;Q9UJU6-5;Q9UJU6-2;Q9UJU6-3;B4DDD6;Q9UJU6-6;Q9UJU6-4 Q9UJU6;Q9UJU6-2 DBNL Drebrin-like protein 0 8709900.0 2622800.0 1835400.0 4251700.0 False True 2539540.6496481327 2568284.7914845585 3138052.221734053 1.0 1.0113186382113664 1.2356770986000352 21.276136136240655 -6.9173771184745565 0.8439612876358621 0.9945663591230665 1.269759616681118 0.9934205257107249 0.008803282641957118 0.09973973342106415 0.11379620255802046 0.007481400060082627 0.021877673840524057 1.2095473701154986e-07 6.9173771184745565 0.2751932575580516 TWEQQQEVVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TWEQQQEVVSR 11 0 Q9UJU6;H0Y5J4;Q9UJU6-5;Q9UJU6-2;Q9UJU6-3;B4DDD6;Q9UJU6-6;Q9UJU6-4 Q9UJU6;Q9UJU6-2 DBNL Drebrin-like protein 0 6778000.0 1759500.0 2189400.0 2829100.0 False True 2410034.6986996317 2092665.068622391 2160924.847143447 1.0 0.8683132528139608 0.8966364045751726 21.200622487265516 -10.334299136845623 5.692622309427707 1.000019078635371 0.8824748286945662 0.9582587419180303 0.011562878287065764 2.800251304247717e-06 3.274857021989771e-07 0.011197525428970474 0.003731902920002051 4.631278129511906e-11 10.334299136845623 -0.11754424994080492 TWEQQQEVVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TWEQQQEVVSR 11 0 Q9UJU6;H0Y5J4;Q9UJU6-5;Q9UJU6-2;Q9UJU6-3;B4DDD6;Q9UJU6-6;Q9UJU6-4 Q9UJU6;Q9UJU6-2 DBNL Drebrin-like protein 0 5814100.0 2622800.0 2077300.0 1114000.0 False True 2180974.409740919 2066109.1725882331 1346932.2494459634 1.0 0.94733306514755 0.6175827847544381 21.05654141167493 -6.934940353962817 0.7050612001825007 1.0042153791243305 0.5405009200852389 0.9974232241822774 0.008590490670955245 0.09015255970158108 0.06569998990859238 0.008070672316981655 0.029069084736308252 1.1616081382356178e-07 6.934940353962817 -0.4637144590390916 TWFQEYMNSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TWFQEYMNSK 10 0 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 0 7828000.0 1492700.0 2640600.0 3694700.0 False True 1956944.1553273604 2246632.772978182 3312407.8860649685 1.0 1.1480311110882784 1.692643030741398 20.900171156161747 -6.94679900357746 0.5929552989905145 0.993758082401331 1.8744591835360453 0.9989254607352006 0.009762580825351783 0.08479733168227489 0.04148389531533332 0.010090659768529103 0.04566573460104575 1.1303189180803181e-07 6.94679900357746 0.8807011011347143 TWFQEYMNSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TWFQEYMNSK 10 0 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 0 4358000.0 0.0 2025000.0 2333000.0 False True 0.0 2833593.060235495 1721917.3115002343 0.0 TWFQEYMNSK(ub)DR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TWFQEYMNSKDR 12 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 21336500.0 6342400.0 7193000.0 7801100.0 True False 6141063.98365423 10065202.410999477 5757757.882016502 1.0 1.6389997625476938 0.9375831122004298 22.550057203903116 -6.666946769463635 1.9480740933506593 1.4089354633163036 0.9404468109533682 0.26562455247945116 0.2716254900324445 0.4681799637737471 3.4223465238440163 0.11236603809484257 0.3014276692268634 2.1530456127017143e-07 6.666946769463635 -0.46848865236293535 TWFQEYMNSK(ub)DR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TWFQEYMNSKDR 12 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 49905000.0 12513000.0 14139000.0 23253000.0 True False 18983135.82283565 11615784.981488774 18657034.35784806 1.0 0.6119002197474473 0.9828215175811307 24.178214994946266 -10.652245361418467 9.484929456556973 1.0001019283745218 0.7973608692971091 0.28466369946422476 0.1514279857372386 0.0003265529817204837 1.197261274914238e-05 0.1466925399900498 0.048873172242504974 2.2271765157684415e-11 10.652245361418467 -0.2027410590774127 TWFQEYMNSK(ub)DR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TWFQEYMNSKDR 12 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 18223800.0 5038900.0 7327700.0 5857200.0 True False 6901917.50115236 7003937.984536535 4473849.992820541 1.0 1.01478146955062 0.6482039218917898 22.718565798619235 -6.897504831484742 0.9769236433284475 1.016301834874501 0.6116192858186859 0.9852830208439454 0.02055412920961242 0.113264737678586 0.1879662682071288 0.01585120017753558 0.0407485929405169 1.2661791813098096e-07 6.897504831484742 -0.40468254905581513 TWFQEYMNSK(ub)DR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TWFQEYMNSKDR 12 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 22073400.0 6342400.0 9648000.0 6083000.0 True False 5273986.615960348 9596024.309021937 7354927.175385812 1.0 1.8195010734350492 1.3945669018438611 22.330462479337392 -10.142690247950727 4.342504572016323 0.9999161257385215 1.607033987185358 0.7312518212241343 0.17347865015946784 60633269.74651496 15.800266194724434 69660.45943605716 0.059386356045271704 7.199622939574074e-11 10.142690247950727 0.6071178614468365 TWFQEYMNSK(ub)DR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TWFQEYMNSKDR 12 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BPA9 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 51609000.0 12513000.0 11838000.0 27258000.0 True False 16198325.168105356 11179204.893561669 22297323.690698568 1.0 0.6901457266442348 1.3765203167178168 23.949341317038716 -6.783960858989058 1.52010742236223 0.8254475546939497 1.3826774514017306 0.7812058172434104 0.1312759674597128 0.24449993871619088 1.1160718801588414 0.06799668582639154 0.15994317203559905 1.6445199297308463e-07 6.783960858989058 0.5572298967077809 TWFSIPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TWFSIPEK 8 0 P00374;P00374-2;B4DM58;C9JJ68;Q86XF0 P00374 DHFR;DHFRL1 Dihydrofolate reductase;Dihydrofolate reductase, mitochondrial 0 3751230.0 696930.0 1562000.0 1492300.0 False True 913681.9790797216 1328955.6886283122 1337891.1111523968 1.0 1.4545057460440036 1.4642853222298933 19.801332575121975 -11.550048308702115 0.6079313303362378 1.5763808631527201e-12 1.4630400337367429 0.9999580448550273 0.0014029533801862624 4.900246900313911 0.30313766495740846 6.479758337633414 0.001684692552894946 2.818069446163962e-12 11.550048308702115 1.4630400337351666 TWFSIPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TWFSIPEK 8 0 P00374;P00374-2;B4DM58;C9JJ68;Q86XF0 P00374 DHFR;DHFRL1 Dihydrofolate reductase;Dihydrofolate reductase, mitochondrial 0 4032230.0 1668100.0 862830.0 1501300.0 False True 1615147.0785717757 1207362.5185990077 1108064.491965412 1.0 0.7475248134471077 0.6860455661692673 20.623234114964504 -13.999999999310312 0.1984102519601043 2.395075383192112 0.6454868601961719 0.9994869312824637 0.003077078268886309 12.499951633368779 0.1412458489466715 6.762986563490086 0.03961602301731192 1.000000001588066e-14 13.999999999310312 -1.7495885229959403 TWFSIPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TWFSIPEK 8 0 P00374;P00374-2;B4DM58;C9JJ68;Q86XF0 P00374 DHFR;DHFRL1 Dihydrofolate reductase;Dihydrofolate reductase, mitochondrial 0 3751130.0 696930.0 1047300.0 2006900.0 False True 954603.8548250842 1001026.8230420334 1532911.553402916 1.0 1.04863061046978 1.6058090962599323 19.864542636644867 -6.9240715985955665 0.7939379258022312 0.9894150255510485 1.704651822804031 0.995239398632873 0.018962945277537613 0.09583479226372883 0.09362898799597988 0.01670136062085183 0.05215443667509043 1.1910456338433654e-07 6.9240715985955665 0.7152367972529825 TWGPEQVCSFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TWGPEQVCSFLR 12 0 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8YG48;A0A2R8Y7R5;A0A2R8Y755 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 5821100.0 1254800.0 2140600.0 2425700.0 False True 1645054.9515004852 1821230.823993448 2174711.8329574266 1.0 1.107094217328284 1.3219691117149803 20.6497043459492 -6.959982237549986 0.4356847115782056 0.9919620071219881 1.4454192338977763 0.9997695365631063 0.0020323628734861075 0.07970748100893729 0.021154823748205015 0.0028185641045072062 0.01781898347163467 1.0965230425279541e-07 6.959982237549986 0.45345722677578815 TWGPEQVCSFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TWGPEQVCSFLR 12 0 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8YG48;A0A2R8Y7R5;A0A2R8Y755 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 6197100.0 1254800.0 2134300.0 2808000.0 False True 1718733.469694968 2039999.5688137251 2144808.2325753053 1.0 1.1869202553993283 1.2479004280727453 20.71291440747209 -13.99999999999962 0.15662262666332868 0.08570761479211997 1.3101383377568265 0.9995456594328752 0.00224808111200381 11.989000832244525 0.12494318062367896 3.3311654217402817 0.05649414004072816 1.0000000000008753e-14 13.99999999999962 1.2244307229647067 TWHAWMDNIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TWHAWMDNIR 10 0 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 32838000.0 10183000.0 10165000.0 12490000.0 False True 13350011.612312289 8648421.622859664 11197654.612539977 1.0 0.64782128091061 0.8387748968107817 23.670337661032086 -10.07704899743213 5.005249050484151 1.000006163529412 0.7432980888594821 0.7067086559685798 0.07795648725334757 5.361932967464943e-06 9.887940882752954e-07 0.07548285695979363 0.02516034807115147 8.374347967694724e-11 10.07704899743213 -0.25670807466992984 TWHAWMDNIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TWHAWMDNIR 10 0 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 25949300.0 8793300.0 5494000.0 11662000.0 False True 8514161.50470907 7687782.850831519 8607372.347499238 1.0 0.9029406884729057 1.0109477419166426 23.02143302611433 -13.722252910747875 16.24543391460826 8.749564317867206 0.9612497936752967 0.0 0.04956953465960747 0.0 0.0 0.0 0.014494164868245472 1.8956016988813353e-14 13.722252910747875 -7.788314524191909 TWHAWMDNIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TWHAWMDNIR 10 0 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 66951000.0 23599000.0 28057000.0 15295000.0 False True 35801408.31799714 23050009.139658447 12271936.545963366 1.0 0.6438296766127871 0.34277803925926403 25.09351300403146 -7.552192393655205 0.2357931229423297 1.1533846417903673 1.2578712787437586e-14 0.9998803681803132 0.0029381060387813976 0.12938429397157233 0.024790168935956456 0.03155255419488099 0.06944705171666482 2.8041910983447572e-08 7.552192393655205 -1.1533846417903546 down TWHAWMDNIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TWHAWMDNIR 10 0 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 31417000.0 10183000.0 11534000.0 9700000.0 False True 13947930.28522783 11024389.742162537 7409059.7777708275 1.0 0.7903961029858604 0.531194207761256 23.733547722554977 -6.96826724345417 0.2966756513498792 1.0467677713690586 0.2667389262944269 0.9999655317979638 0.0011257179940428591 0.07686910509221817 0.011032301830347358 0.0043727594695180914 0.023329887414996798 1.0758030136696916e-07 6.96826724345417 -0.7800288450746318 TWHAWMDNIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TWHAWMDNIR 10 0 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 23506300.0 8793300.0 9530100.0 5182900.0 False True 7312018.5592400655 9478759.45972327 6266620.426977991 1.0 1.2963259574533126 0.8570301588005376 22.801838301548607 -6.7250192068082235 1.7415763582434545 1.179310557100573 0.8575285726219624 0.5359658682581222 0.12462437610865218 0.3456454312277592 2.0514773119197343 0.05676488099140537 0.1416494920455161 1.8835657863663894e-07 6.7250192068082235 -0.3217819844786107 TWHAWMDNIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TWHAWMDNIR 10 0 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 0 60134000.0 23599000.0 18747000.0 17788000.0 False True 30549370.705835376 17703712.970062558 14550766.520292953 1.0 0.5795115434793847 0.47630331440881507 24.86463932612391 -13.999999999999998 0.1972849705314004 3.3137150947795995 0.40745317662249064 0.9994870213589163 0.005130004948510631 12.478510105215568 0.14084773636474052 11.128544968534667 0.06707324863426987 1.0000000000000041e-14 13.999999999999998 -2.9062619181571088 TWIEGLTGLSIGPDFQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TWIEGLTGLSIGPDFQK 17 0 B4DDF4;B4DUT8;Q99439;A0A087X271;H3BVI6;Q99439-2;K7ES69 B4DDF4 CNN2 Calponin;Calponin-2 0 18995300.0 8351000.0 3755500.0 6888800.0 False True 8085902.076106295 5255090.734673778 5084416.620429837 1.0 0.6499077882976697 0.6288001725193041 22.946977301356824 -13.999999999999998 0.39961693136152904 6.886913441831357 0.6275499492551295 0.9998372255837794 0.0021718187499651194 26.712800956394698 0.2082890852365054 136.3348341627659 0.005406448914445107 1.0000000000000041e-14 13.999999999999998 -6.259363492576227 TWIEGLTGLSIGPDFQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TWIEGLTGLSIGPDFQK 17 0 B4DDF4;B4DUT8;Q99439;A0A087X271;H3BVI6;Q99439-2;K7ES69 B4DDF4 CNN2 Calponin;Calponin-2 0 4581840.0 854840.0 0.0 3727000.0 False True 1170897.4491823756 0.0 2846759.35997442 1.0 0.0 2.4312627565823806 20.15918329500551 -6.795017068712877 1.4762465870264918 0.44472431260536505 2.460817711241107 0.8171848184425229 0.42660703554203416 0.22793854418591677 0.9811465421577286 0.22740318042464983 0.5305237304823713 1.6031823809152605e-07 6.795017068712877 2.016093398635742 TWIEGLTGLSIGPDFQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TWIEGLTGLSIGPDFQK 17 0 B4DDF4;B4DUT8;Q99439;A0A087X271;H3BVI6;Q99439-2;K7ES69 B4DDF4 CNN2 Calponin;Calponin-2 0 15565400.0 8351000.0 3204900.0 4009500.0 False True 6944226.512027773 3187634.5675771567 4847867.912166599 1.0 0.459033783252318 0.6981148877804939 22.7273825767911 -10.34525918846117 5.8537692754184425 1.0000619468652525 0.5785743355164075 0.8055520320322173 0.09760445220584318 7.892048494246777e-05 8.827383350687657e-06 0.09451892988926855 0.031501701492410224 4.515863556254669e-11 10.34525918846117 -0.42148761134884505 TWIEVSGSSAK(ub)DVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TWIEVSGSSAKDVAK 15 1 B4DR61;P61619;Q8TC24;Q9H9S3-2;Q9H9S3-3;Q9H9S3;F8W776;P61619-3 B4DR61 SEC61A1;SEC61A2 Protein transport protein Sec61 subunit alpha isoform 1;Protein transport protein Sec61 subunit alpha isoform 2 1 49342330.0 935030.0 2904300.0 45503000.0 True False 905347.9844595448 4064002.1357244155 33584399.23926072 1.0 4.488884059481787 37.09556967679031 19.788112895316846 -6.927323506667766 0.7684406395254991 0.45182449611285613 43.35512027659334 0.9959855967153184 1.029956221803722 0.09405170365586556 0.08466371743616609 0.9238098907959992 2.994939459627921 1.1821606342817842e-07 6.927323506667766 42.903295780480484 TWIEVSGSSAK(ub)DVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TWIEVSGSSAKDVAK 15 1 B4DR61;P61619;Q8TC24;Q9H9S3-2;Q9H9S3-3;Q9H9S3;F8W776;P61619-3 B4DR61 SEC61A1;SEC61A2 Protein transport protein Sec61 subunit alpha isoform 1;Protein transport protein Sec61 subunit alpha isoform 2 1 39841230.0 935030.0 2157200.0 36749000.0 True False 777518.8738523913 2145578.7354293237 44433045.991822004 1.0 2.759519810494855 57.14722495631332 19.568518170751123 -6.911650787502105 0.8858090312717515 2.0374000494402994e-13 64.39413402521699 0.9923350752028697 2.281824524569764 0.10019112649575682 0.12941131735225714 1.9131028616595547 5.333640562689521 1.225601298733743e-07 6.911650787502105 64.39413402521679 up TWK(ub)ESPSAIA ddPTM_RPMI8226_Bortezomib_1h_R1 1 TWKESPSAIA 10 1 Q8NBI5;H0YCF1;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 46166000.0 10019000.0 13548000.0 22599000.0 True False 13135006.024134012 11526691.209690364 20260672.264915206 1.0 0.8775550759939843 1.5424943260542576 23.646913526349337 -6.8591718591166995 1.1899591505985916 0.9337105039132368 1.5741815442730989 0.952623665476178 0.0628935018883758 0.14765414221233472 0.3977680980321843 0.041237837884526604 0.09617055238277562 1.383018982067112e-07 6.8591718591166995 0.640471040359862 TWK(ub)ESPSAIA ddPTM_RPMI8226_Bortezomib_2h_R1 1 TWKESPSAIA 10 1 Q8NBI5;H0YCF1;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 19966700.0 2837300.0 2643400.0 14486000.0 True False 2747231.464559499 3698923.4051488936 10691682.029315231 1.0 1.3464185500445236 3.8918024080761513 21.389547037329567 -6.931714090511291 0.7325841159507532 0.9636488864367362 4.437925110923655 0.9968645670661724 0.07219633588717461 0.09175745993689594 0.07339081590564797 0.06645817632272308 0.22818112053069986 1.1702695621235855e-07 6.931714090511291 3.474276224486919 up TWK(ub)ESPSAIA ddPTM_RPMI8226_Bortezomib_8h_R1 1 TWKESPSAIA 10 1 Q8NBI5;H0YCF1;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 68075500.0 7859500.0 25295000.0 34921000.0 True False 11923436.106415456 20780909.619262923 28018849.04358196 1.0 1.742862496498108 2.3498971935201043 23.507296717068996 -6.973430266158997 0.1557921808425078 0.3489778494175042 3.759827900318908 0.9999982795997976 0.0007240317488878857 0.07520461724625055 0.00478889251994577 0.02926089969256554 0.07400855440785857 1.0630892677988846e-07 6.973430266158997 3.410850050901404 TWK(ub)ESPSAIA ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TWKESPSAIA 10 1 Q8NBI5;H0YCF1;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 39745500.0 10019000.0 6880500.0 22846000.0 True False 13723295.053294454 6576496.7592291795 17450245.3281394 1.0 0.47922140664390994 1.2715783826239488 23.71012358787223 -6.72937324536574 1.7251999074094366 0.6863926193438739 1.2710846996096343 0.5565505345564841 0.21893309648977208 0.33738692139116566 1.966913783674765 0.10057122772554773 0.2497680162231547 1.8647763586756813e-07 6.72937324536574 0.5846920802657605 TWK(ub)ESPSAIA ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TWKESPSAIA 10 1 Q8NBI5;H0YCF1;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 19801500.0 2837300.0 4278200.0 12686000.0 True False 2359340.663702118 4255152.487443786 15338583.946563292 1.0 1.8035345861275023 6.501216285780037 21.169952312763844 -6.936386525956286 0.6923619949054949 0.9425534166933145 7.643826959627352 0.9976512943492517 0.11758117473281932 0.08945444008107406 0.06241017376388726 0.11153591465202577 0.41116686875480707 1.1577464927960673e-07 6.936386525956286 6.701273542934037 TWK(ub)ESPSAIA ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TWKESPSAIA 10 1 Q8NBI5;H0YCF1;Q8NBI5-2 Q8NBI5;Q8NBI5-2 SLC43A3 Solute carrier family 43 member 3 1 51062500.0 7859500.0 14768000.0 28435000.0 True False 10174277.683906648 13946147.817884669 23260121.767738417 1.0 1.3707260850511527 2.28616934689433 23.278423039161446 -6.955725667189834 0.4919886057596664 0.9803225773196977 2.7155229692831226 0.999577365557357 0.011112575152856375 0.08126483400457632 0.027053453723847744 0.013237296799215656 0.07550352338986695 1.1073230309821972e-07 6.955725667189834 1.735200391963425 up TWKPTLVILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TWKPTLVILR 10 1 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 134842000.0 37379000.0 38172000.0 59291000.0 False True 49004230.978750944 32476886.39329057 53156136.07943223 1.0 0.662736374893284 1.0847254414110001 25.546402979736264 -6.693806688651452 1.8525055498433596 0.7893253281757275 1.083354800110779 0.3885256236280483 0.14252905858322817 0.40850910575092053 2.7208243647964565 0.06147793750943509 0.15935152397019364 2.0239198569762433e-07 6.693806688651452 0.29402947193505136 TWKPTLVILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TWKPTLVILR 10 1 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 116152000.0 40414000.0 22444000.0 53294000.0 False True 39131079.6915052 31406006.24391384 39334702.614270724 1.0 0.8025847099417407 1.0052036111543767 25.22181158135264 -11.06157884198459 9.829487241043623 1.387291725245969 0.9038941605480587 0.2307517047371881 0.082718820035725 0.04695565384882568 0.0002941636608064049 0.005356777469889789 0.026697384368024272 8.678030217025076e-12 11.06157884198459 -0.4833975646979104 TWKPTLVILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TWKPTLVILR 10 1 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 75036000.0 22369000.0 26017000.0 26650000.0 False True 33935408.39295216 21374063.078251213 21382615.81889007 1.0 0.6298454649713384 0.6300974949613659 25.016288039438464 -9.947997479040874 5.206414722241994 1.000001233314351 0.6299714799632321 0.9999996509717761 0.00010289082346559324 1.4728779041243349e-09 2.976781793965377e-10 9.962393775983671e-05 3.3207868912198075e-05 1.1272039992633925e-10 9.947997479040874 -0.370029753351119 TWKPTLVILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TWKPTLVILR 10 1 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 134741000.0 37379000.0 38537000.0 58825000.0 False True 51199026.42949336 36834307.915182665 44931746.53890406 1.0 0.7194337565365139 0.8775898620021608 25.609613041259156 -10.149597138676333 5.032536545143717 1.000010581951913 0.7985118095882647 0.6839487277624681 0.06456695968402384 7.666334648674647e-06 1.2955336327738473e-06 0.06251997192982865 0.02083889663077667 7.086027954892582e-11 10.149597138676333 -0.20149877236364822 TWKPTLVILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TWKPTLVILR 10 1 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 93842000.0 40414000.0 25740000.0 27688000.0 False True 33606031.643766075 25601333.511010006 33477432.785152458 1.0 0.7618076951897133 0.9961733399534701 25.002216856786916 -10.801999316308127 9.15637054684236 1.0018614516981121 0.878990517583474 0.26224258886620777 0.09567937381826476 0.0036860573450785044 7.970844070797244e-05 0.0939226953530075 0.030880385114474444 1.5776137532695948e-11 10.801999316308127 -0.12287093411463812 TWKPTLVILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TWKPTLVILR 10 1 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2;C9JBJ7 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 0 90033000.0 22369000.0 33996000.0 33668000.0 False True 28957111.45891061 32104092.715114277 27540769.46285271 1.0 1.108677319582416 0.951088284545658 24.787414361530914 -6.721128177112474 1.7552144251921804 1.0660349488509857 0.9513164371951811 0.517973331035348 0.045725117350289564 0.3530699857804404 2.1263735434875026 0.020680014501289694 0.05184661154125786 1.9005172809254405e-07 6.721128177112474 -0.1147185116558046 TWNDPSVQQDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TWNDPSVQQDIK 12 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 243315000.0 47330000.0 106020000.0 89965000.0 False True 62050088.34437195 90202229.2627231 80656284.80521688 1.0 1.4537002552213867 1.2998576949251441 25.886929928618684 -10.022846921286707 4.835125667510828 0.9999928972152572 1.3767789750806592 0.8888591094922195 0.06280596226701067 4.808897905621827e-06 9.719585395207978e-07 0.060812757388771184 0.02027053715492883 9.487528176936952e-11 10.022846921286707 0.37678607786540197 TWNDPSVQQDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TWNDPSVQQDIK 12 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 180468000.0 50698000.0 37775000.0 91995000.0 False True 49088619.74068218 52858754.494022615 67898749.70915738 1.0 1.076802622955315 1.3831871840732632 25.548885266212544 -6.944937073432761 0.611916918754792 0.9966198756523835 1.4793778877242094 0.9987416002844097 0.0058720079097078475 0.08558485737193643 0.044884183813579434 0.005957982540181308 0.025852628432221088 1.1351752835897348e-07 6.944937073432761 0.4827580120718259 TWNDPSVQQDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TWNDPSVQQDIK 12 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 543865000.0 104630000.0 363510000.0 75725000.0 False True 158731359.47760662 298638800.3834067 60757920.55855339 1.0 1.8814102100948604 0.38277200396009303 27.242011938900475 -6.747307753314794 1.6597157294942195 1.5199429767154011 0.3803748716566046 0.6373618551864315 0.3703357544371388 0.3047550812739205 1.650831700873353 0.17632607064731912 0.4293046590403668 1.7893374297147548e-07 6.747307753314794 -1.1395681050587965 TWNDPSVQQDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TWNDPSVQQDIK 12 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 217466000.0 47330000.0 95861000.0 74275000.0 False True 64829180.04515684 91625544.05006422 56732774.741642065 1.0 1.4133380059140397 0.8751117120735569 25.950139990141576 -6.701490980451846 1.8251394710655777 1.2562775903093566 0.8766429201902964 0.4249075518986666 0.17442618784945332 0.3923961852888229 2.542164051011303 0.07620622899301155 0.19565246532395536 1.9884241061108076e-07 6.701490980451846 -0.37963467011906016 TWNDPSVQQDIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TWNDPSVQQDIK 12 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 113940000.0 50698000.0 38553000.0 24689000.0 False True 42157633.30221338 38345307.33682869 29851355.750961717 1.0 0.9095697346657139 0.7080889844305953 25.32929054164682 -6.957880015615881 0.4643528246410359 1.0056243658609043 0.6038527905009595 0.9996832917180241 0.0021713691358084116 0.08046737357814283 0.023997135375239894 0.002757147897569463 0.01663700834227752 1.1018436785354231e-07 6.957880015615881 -0.4017715753599448 TWNDPSVQQDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TWNDPSVQQDIK 12 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 295612000.0 104630000.0 102930000.0 88052000.0 False True 135445597.56564063 97201855.0172582 72027439.48981546 1.0 0.7176449937411331 0.5317813261144129 27.013138260992925 -8.435088994640394 0.11014837696568605 1.5215870215439895 1.679172549662397e-15 0.9999720546766363 0.0010175908396802302 0.12445057244298476 0.02567097039547341 0.17341421033600277 0.16055445184549297 3.6720704555274267e-09 8.435088994640394 -1.5215870215439877 TWNDPSVQQDIK(ub)FLPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TWNDPSVQQDIKFLPFK 17 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 15934500.0 1798000.0 2217500.0 11919000.0 True False 1740923.4741754415 3102959.314109735 8797056.337664505 1.0 1.7823639925237946 5.053097662337559 20.73142135711844 -6.943861177509823 0.6226057427269107 0.9642584726457406 6.0452573585056975 0.998627166993038 0.06504597355838408 0.08604844034287672 0.04691369804646979 0.06535138378035912 0.27707771761067146 1.1379909871894692e-07 6.943861177509823 5.080998885859957 TWNDPSVQQDIK(ub)FLPFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TWNDPSVQQDIKFLPFK 17 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 14480200.0 1798000.0 1779200.0 10903000.0 True False 1495116.664905512 1769615.0964564506 13182766.890223814 1.0 1.1835966637214135 8.817216207711079 20.511826632552715 -6.912074890315659 0.8814805973987277 0.77887122574866 9.84882151099703 0.991681346425655 0.3322264493715619 0.10306227593694203 0.13144134381676376 0.2748193218703793 0.7699934875885592 1.2244050430322629e-07 6.912074890315659 9.069950285248371 up TWPSSHNWFFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TWPSSHNWFFAK 12 0 A0A3B3IRL2;O75629 A0A3B3IRL2 CREG1 Protein CREG1 0 29111430.0 8015030.0 11255000.0 9841400.0 False True 10507781.947660934 9575797.87164638 8823106.333374782 1.0 0.9113053467747285 0.8396735274221058 23.324954832006203 -6.973552883951713 0.15084805472240567 1.0822876107456705 0.6668059305861346 0.9999985004364528 8.009491866079996e-05 0.07516580085074698 0.004614571082704853 0.003624990423073262 0.008905224497439404 1.0627891597736811e-07 6.973552883951713 -0.4154816801595359 TWPSSHNWFFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TWPSSHNWFFAK 12 0 A0A3B3IRL2;O75629 A0A3B3IRL2 CREG1 Protein CREG1 0 33661300.0 11254000.0 8591300.0 13816000.0 False True 10896747.930128159 12021850.893037627 10197175.128884364 1.0 1.1032512608462473 0.9357998546236385 23.37739429966155 -6.739880514907509 1.687029608009667 1.061441827004554 0.9357020791049337 0.6044621678245211 0.04338189692760325 0.31802668730054257 1.777157549773396 0.020343049415318313 0.04992857607549396 1.820201571943853e-07 6.739880514907509 -0.12573974789962028 TWPSSHNWFFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TWPSSHNWFFAK 12 0 A0A3B3IRL2;O75629 A0A3B3IRL2 CREG1 Protein CREG1 0 46307000.0 15151000.0 17033000.0 14123000.0 False True 22985174.68646872 13993328.070563575 11331582.859669188 1.0 0.6087979865909564 0.4929952899744567 24.45420029483632 -13.999999999205903 0.1706291923414877 2.976113301701641 0.391525294018311 0.9995124913400855 0.004789584850511243 12.09767964998693 0.1308190465471144 7.913226203614618 0.09387420451574992 1.0000000018284764e-14 13.999999999205903 -2.5845880076833296 TWPSSHNWFFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TWPSSHNWFFAK 12 0 A0A3B3IRL2;O75629 A0A3B3IRL2 CREG1 Protein CREG1 0 38161030.0 8015030.0 12141000.0 18005000.0 False True 10978403.189041495 11604570.475081956 13752589.824614825 1.0 1.0570362807102487 1.2526949127121227 23.388164893529094 -6.948405041755146 0.576094890542134 0.9976253695702267 1.3217185894639052 0.9990700437102076 0.003299965306260865 0.08413273884821823 0.038663303675746434 0.003472287110071226 0.01632740738847503 1.1261466733161466e-07 6.948405041755146 0.32409321989367845 TWPSSHNWFFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TWPSSHNWFFAK 12 0 A0A3B3IRL2;O75629 A0A3B3IRL2 CREG1 Protein CREG1 0 34566800.0 11254000.0 14884100.0 8428700.0 False True 9358199.636733394 14803916.399037454 10191102.200094426 1.0 1.5819192765377852 1.0890024359056918 23.157799575095826 -10.238479629964422 4.142847703761749 0.9997756503827929 1.3354608562039396 0.3817827181102357 0.20123245769295792 141995730.81134725 130.9804958724936 318093.956076776 0.06888722271267768 5.7745795701683345e-11 10.238479629964422 0.3356852058211467 TWPSSHNWFFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TWPSSHNWFFAK 12 0 A0A3B3IRL2;O75629 A0A3B3IRL2 CREG1 Protein CREG1 0 69020000.0 15151000.0 36450000.0 17419000.0 False True 19613268.170859456 34421525.45787488 14248920.734033221 1.0 1.7550122273358242 0.7264939534760275 24.22532661692877 -6.709970956998046 1.795226596383513 1.4641842365933209 0.728909051368329 0.46494609665399045 0.31816062879448864 0.3751641448720336 2.3568873532861794 0.1410328444559151 0.35831329213870416 1.949974997993429e-07 6.709970956998046 -0.7352751852249919 TWQANLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TWQANLR 7 0 P06730;P06730-2;D6RBW1;P06730-3;H0Y8J7 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 9277000.0 1910500.0 3925800.0 3440700.0 False True 2504684.0013083196 3340085.942648541 3084689.3695249273 1.0 1.3335358635675598 1.2315682808344854 21.25619716935047 -10.096394875656628 4.286806339770478 0.9999654376586737 1.282552072137416 0.9110155127843009 0.0416280914944425 6068113.963814836 7145888.739745796 1702.1675270952683 0.014250403258717736 8.009494810700118e-11 10.096394875656628 0.2825866344787422 TWQANLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TWQANLR 7 0 P06730;P06730-2;D6RBW1;P06730-3;H0Y8J7 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 5512900.0 1908800.0 1243300.0 2360800.0 False True 1848206.1888242948 1739756.1737238492 1742435.6575181123 1.0 0.9413214738938656 0.9427712492546805 20.817694284411857 -10.071136676241567 6.472716216454091 1.000000056339373 0.942046361574273 0.9995308207550391 0.000591868312610273 4.807687702770502e-10 6.992314997896938e-11 0.0005730745845370311 0.00019102467649048522 8.489132726206566e-11 10.071136676241567 -0.05795369476509993 TWQANLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TWQANLR 7 0 P06730;P06730-2;D6RBW1;P06730-3;H0Y8J7 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 19660600.0 6171100.0 10299000.0 3190500.0 False True 9362009.867841529 8461062.983545728 2559896.276554176 1.0 0.9037656553438861 0.2734344774990476 23.158386855019046 -6.934008320420648 0.713120854255491 1.0083083241690713 0.12974843117622353 0.997269088680288 0.016839010652488162 0.09060926934634159 0.06787080444536936 0.01572490731933665 0.05583051728854569 1.1641037267428977e-07 6.934008320420648 -0.8785598929928478 down TWQANLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TWQANLR 7 0 P06730;P06730-2;D6RBW1;P06730-3;H0Y8J7 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 5311100.0 1910500.0 1353600.0 2047000.0 False True 2616863.479321198 1293793.4762433849 1563540.759288339 1.0 0.4944061799429402 0.5974865603970727 21.319407230873363 -10.011726014651414 6.006264960259717 1.0000005263465044 0.5459463701700283 0.962784151421066 0.042082389100917335 2.965865430906639e-07 4.88258460420595e-08 0.04074614478850751 0.013582032679683676 9.733610988913245e-11 10.011726014651414 -0.45405415617647604 TWQANLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TWQANLR 7 0 P06730;P06730-2;D6RBW1;P06730-3;H0Y8J7 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 6151900.0 1908800.0 2631100.0 1612000.0 False True 1587251.7741777757 2616925.742067543 1949061.746954121 1.0 1.6487149579172191 1.2279474363566354 20.598099559846133 -10.17361658371535 4.383656567505132 0.9999040676000285 1.4383311970070256 0.5913310703886523 0.17177762148445042 0.00017551753322948488 3.30872870709608e-05 0.16636243699120706 0.05544098892017524 6.704762772586162e-11 10.17361658371535 0.43842712940699713 TWQANLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TWQANLR 7 0 P06730;P06730-2;D6RBW1;P06730-3;H0Y8J7 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 16180700.0 6171100.0 5571500.0 4438100.0 False True 7988610.600567005 5261441.127257885 3630411.3387515307 1.0 0.6586177985549134 0.4544484041435011 22.929513177111495 -9.398094761591594 0.12136805345785769 1.6387537764824092 2.668213282445346e-10 0.9999040488053667 0.0022045253266502617 0.8462333662543458 0.04604391754259132 0.3931915696424237 0.2122243641204085 3.9985749268518253e-10 9.398094761591594 -1.638753776215588 TWSEK(ub)DLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TWSEKDLR 8 1 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4;E9PQK4;E9PSH0;E9PKU1;F5H4Y5;F5H0D8;E9PKA1 G5EA30 CELF1 CUGBP Elav-like family member 1 1 3783800.0 1337000.0 1269000.0 1177800.0 True False 1752819.9475264184 1079670.1465232586 1055932.5542553721 1.0 0.6159618094527567 0.6024192934051814 20.741246377086313 TWSEK(ub)DLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TWSEKDLR 8 1 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4;E9PQK4;E9PSH0;E9PKU1;F5H4Y5;F5H0D8;E9PKA1 G5EA30 CELF1 CUGBP Elav-like family member 1 1 3555310.0 1337000.0 729510.0 1488800.0 True False 1831325.0310664435 697277.8360330322 1137176.1027984766 1.0 0.38075045347192316 0.6209580950991861 20.804456438609204 -10.261837006386898 5.596170812224783 1.0000369267560227 0.5008542742855644 0.8520121738612316 0.09806435905073117 4.518324660632762e-05 5.959794756093114e-06 0.09495741061688029 0.03165013578832568 5.4722130015985267e-11 10.261837006386898 -0.49918265247045834 TWSEK(ub)DLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TWSEKDLR 8 1 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4;E9PQK4;E9PSH0;E9PKU1;F5H4Y5;F5H0D8;E9PKA1 G5EA30 CELF1 CUGBP Elav-like family member 1 1 13399500.0 2966500.0 3186400.0 7246600.0 True False 3840192.7284571617 3009074.0389292873 5927793.15639504 1.0 0.7835737036401855 1.5436186607166964 21.872747286888323 -6.830603498449216 1.3251254514011794 0.8844005905263205 1.5643360963176807 0.9070876982899219 0.09745773891522459 0.18007116201118606 0.6181734963493818 0.0577403164451196 0.13288069219233592 1.4770544369118328e-07 6.830603498449216 0.6799355057913602 TWTVVDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TWTVVDAK 8 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 5082300.0 1715400.0 1332300.0 2034600.0 False True 1660945.5659624885 1864294.337852717 1501677.2233083488 1.0 1.1224295221092278 0.9041098360367719 20.663573362068885 -6.754522100119356 1.632939638867848 1.07159616644096 0.9035172352053834 0.6682573441958173 0.05146179382354182 0.2922260543733777 1.534364386590066 0.024880706801912036 0.06012369827427112 1.7598591068590422e-07 6.754522100119356 -0.1680789312355765 TWTVVDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TWTVVDAK 8 0 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 4668460.0 1715400.0 1957500.0 995560.0 False True 1426431.1051050706 1946954.5589666713 1203726.9930506495 1.0 1.364913140213147 0.8438732082766683 20.44397863750316 -6.718465259191072 1.7651356008171903 1.2223742194280423 0.8447705447995033 0.5051544698270646 0.15358621290164606 0.3582954720103437 2.1809215200442473 0.06911504987307758 0.17379906482722224 1.9122062828825899e-07 6.718465259191072 -0.37760367462853894 TYADYESVNECMEGVCK ddPTM_RPMI8226_Bortezomib_1h_R1 2 TYADYESVNECMEGVCK 17 0 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 0 36854500.0 7657700.0 17980000.0 11216800.0 False True 10039318.857272284 15297454.085491065 10056193.135143192 1.0 1.5237541812321154 1.001680818998859 23.25915805356288 -10.735370369955675 2.9996561230368908 0.9578239615325984 1.2627175002280604 0.25241458490554103 0.2131355605479324 79470226.42407668 49862576.969667666 24410846.82105445 0.07799963047030974 1.8392028449462052e-11 10.735370369955675 0.304893538695462 TYADYESVNECMEGVCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYADYESVNECMEGVCK 17 0 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 0 79621000.0 12503000.0 54452000.0 12666000.0 False True 18967965.09173771 44734615.16458214 10162559.548294976 1.0 2.3584298551913814 0.5357748972620001 24.177061577039538 -6.707134715013736 1.8051512644959335 1.8375431210929165 0.5403555600103598 0.45163054524179325 0.5726955917742945 0.38085147067792374 2.4172923952779692 0.25262784240655406 0.6440975914145706 1.962751351095927e-07 6.707134715013736 -1.2971875610825567 TYADYESVNECMEGVCK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TYADYESVNECMEGVCK 17 0 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 0 45160100.0 7657700.0 18419600.0 19082800.0 False True 10488958.631561328 17605761.166528244 14575835.66260259 1.0 1.6785042047503573 1.38963610922669 23.322368115085773 -9.993324193176772 4.408380421444931 0.999981054959027 1.5340701568826787 0.8200662127291828 0.11792990652330775 13474719.89362307 6109148.1949736355 2389.6659486788235 0.04037054422639982 1.0154903642064537e-10 9.993324193176772 0.5340891019236517 TYADYESVNECMEGVCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYADYESVNECMEGVCK 17 0 P84090;G3V279 P84090 ERH Enhancer of rudimentary homolog 0 29303700.0 12503000.0 7372900.0 9427800.0 False True 16185379.970975874 6962591.63370002 7712037.137397016 1.0 0.4301778300037166 0.4764816860170401 23.948187899131987 -9.986272516415404 7.39670229367516 1.000000017357773 0.45332975970252687 0.994648023738289 0.01890347005932468 5.38034495500085e-09 7.743342431818839e-10 0.018303206726800074 0.0061010687271078725 1.0321135592785216e-10 9.986272516415404 -0.5466702576552461 TYAFSENPLPTVEIAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYAFSENPLPTVEIAIR 17 0 G5E975;Q12824-2;Q12824;A0A0G2JRV3 G5E975 SMARCB1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 0 36430000.0 14634000.0 21796000.0 0.0 False True 22200847.888705898 17906333.50707473 0.0 1.0 0.8065607942921904 0.0 24.404111440853224 -7.24057516213531 0.8601426829895621 0.9894614839054495 1.8225595598211986e-16 0.9889250742222611 0.04557535981501257 0.09733989070530014 0.13847185037494644 0.038579045988983485 0.06788360338166788 5.7467835225815926e-08 7.24057516213531 -0.9894614839054493 down TYAICGAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYAICGAIR 9 0 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 297532000.0 81603000.0 126550000.0 89379000.0 False True 106982323.24457611 107669233.28803636 80130918.46390808 1.0 1.0064207807666494 0.7490108275244493 26.672797198023055 -6.901178785886919 0.9537707130250866 1.01035876980255 0.7213336080911169 0.9871441150689658 0.013590122563419602 0.11054329455077003 0.17256026568938976 0.010662393019411428 0.027909913061480714 1.2555130006101738e-07 6.901178785886919 -0.2890251617114331 TYAICGAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYAICGAIR 9 0 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 75031000.0 45026000.0 14202000.0 15803000.0 False True 43596674.27598632 19872932.662451595 11663720.220162116 1.0 0.45583597814473414 0.26753692601241974 25.37771474901781 -13.999999999999146 0.14803057343337625 3.6236077437949774 0.05560530078170349 0.9995729461523967 0.006417975516546908 11.950858241031737 0.12106664515555478 9.02439271482238 0.19067054527737448 1.0000000000019674e-14 13.999999999999146 -3.568002443013274 TYAICGAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYAICGAIR 9 0 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 412570000.0 113780000.0 170530000.0 128260000.0 False True 172612578.4322097 140097589.1430287 102909354.78164501 1.0 0.8116302439572755 0.5961868811435471 27.362962357918008 -6.969371941197987 0.2727693294724971 1.0517912637009479 0.34952488682112237 0.9999770602135624 0.0007901563015197003 0.07650701312933088 0.009757152213476412 0.0041527458231117335 0.019962110878133706 1.0730700133626593e-07 6.969371941197987 -0.7022663768798255 TYAICGAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYAICGAIR 9 0 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 233326000.0 81603000.0 80908000.0 70815000.0 False True 111773834.33815627 77333217.03302287 54089955.48070533 1.0 0.6918722748569394 0.4839232348159736 26.736007259545946 -8.173401633914533 0.13166770507496917 1.4242300890294235 5.878153864192651e-13 0.9999607303505894 0.0013285366675825445 0.08646778584580761 0.025541151717650663 0.1225355702201408 0.13108676593624807 6.708082050615727e-09 8.173401633914533 -1.4242300890288357 down TYAICGAIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYAICGAIR 9 0 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 110547000.0 45026000.0 28169000.0 37352000.0 False True 37441113.99000865 28017248.005891275 45162130.503865 1.0 0.7483016668085201 1.2062175958737964 25.158120024452085 -6.757459345761608 1.6218730870464693 0.8533395723701562 1.2076928084882474 0.6805701647296498 0.10583046956049265 0.2872084312318941 1.4883778032221968 0.05149737644652898 0.12407669488024527 1.747996884474207e-07 6.757459345761608 0.3543532361180912 TYAICGAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYAICGAIR 9 0 P63220;Q8WVC2;Q9BYK1 P63220 RPS21 40S ribosomal protein S21 0 290240000.0 113780000.0 176460000.0 0.0 False True 147290452.9391055 166639845.87919343 0.0 1.0 1.1313689553802075 0.0 27.134088680010457 -6.944652121274586 1.2134324873551925 1.0726704967060283 2.329249949854129e-22 0.9700164056396423 0.08748327920537109 0.10995453102209152 0.3222380887998839 0.05982825589730708 0.11421635612590461 1.1359203466805815e-07 6.944652121274586 -1.0726704967060283 down TYASGYAHYEEQEN ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYASGYAHYEEQEN 14 0 Q9Y3S2 Q9Y3S2 ZNF330 Zinc finger protein 330 0 3954540.0 1423100.0 924040.0 1607400.0 False True 1865697.8813200032 786176.8338797089 1441081.6672695575 1.0 0.4213848564396072 0.7724089101982445 20.831283954007933 -10.35518081608136 6.295132261746528 1.0000351717605922 0.5968968833189511 0.6374601518259092 0.14330496985865906 7.074554869398639e-05 7.246750443951306e-06 0.13876650840977342 0.04625148014094516 4.4138664023057433e-11 10.35518081608136 -0.4031382884416411 TYASGYAHYEEQEN ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYASGYAHYEEQEN 14 0 Q9Y3S2 Q9Y3S2 ZNF330 Zinc finger protein 330 0 3062110.0 1069000.0 347610.0 1645500.0 False True 1035065.1801410165 486412.48576220253 1214494.1860581373 1.0 0.4699341597945881 1.173350441459808 19.981290189324483 -6.7051251691296105 1.8125351869785449 0.6725078920459533 1.1714716917274337 0.4418602731486695 0.22354645567311243 0.3850057318059886 2.4624272796875424 0.09826187580707739 0.2511225121769501 1.9718543409983606e-07 6.7051251691296105 0.4989637996814804 TYASGYAHYEEQEN ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYASGYAHYEEQEN 14 0 Q9Y3S2 Q9Y3S2 ZNF330 Zinc finger protein 330 0 3633300.0 1423100.0 1040500.0 1169700.0 False True 1949258.527831454 994527.2695266252 893440.9507276843 1.0 0.5102079869482652 0.4583491301800975 20.894494015530825 -13.999999999999998 0.31719689847007765 5.93926403146427 0.4477284584651752 0.9996876906196109 0.004312624108313122 17.798409481787772 0.17948799816128677 58.25159941678115 0.017457233310967577 1.0000000000000041e-14 13.999999999999998 -5.491535572999095 TYAVGIQQVLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYAVGIQQVLLK 12 0 O15397;O15397-2;F5H244 O15397 IPO8 Importin-8 0 4879270.0 893870.0 1713000.0 2272400.0 False True 1171872.2262493924 1457427.077221701 2037273.8463999887 1.0 1.24367404959006 1.7384777971232723 20.160383845052284 -6.95974723989707 0.43898813435260103 0.9821201010257912 2.0192908259886853 0.9997606917608036 0.004752844167838405 0.07979163464463576 0.021466487681085895 0.0065155851873078775 0.04100549421024757 1.0971165339959888e-07 6.95974723989707 1.037170724962894 TYAVGIQQVLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYAVGIQQVLLK 12 0 O15397;O15397-2;F5H244 O15397 IPO8 Importin-8 0 3099420.0 893870.0 923650.0 1281900.0 False True 1224357.8949284668 882840.0888979039 979141.6215592186 1.0 0.7210637449677114 0.7997184692605139 20.223593906575175 -10.006776153290389 6.680059954434566 1.000000055553073 0.7603911071141117 0.92522564103126 0.032110656729446956 2.655182513818078e-08 3.987884969351212e-09 0.031091016868237505 0.010363669895743697 9.845184214951059e-11 10.006776153290389 -0.2396089484389613 TYCQPCFNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYCQPCFNK 9 0 O60711;O60711-2;B7Z5P7 O60711 LPXN Leupaxin 0 5618000.0 1823200.0 2481200.0 1313600.0 False True 2390232.8558939127 2111014.6316418513 1177681.2729409537 1.0 0.8831836724344424 0.4927056667458108 21.188719741370893 -6.948997428992628 0.5697454908599495 1.0048697316524404 0.3520431988895811 0.9991202281783197 0.006433883759456628 0.08389086743078156 0.03764808826014814 0.006818285986713489 0.03253244650415843 1.1246116316067471e-07 6.948997428992628 -0.6528265327628593 down TYCQPCFNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYCQPCFNK 9 0 O60711;O60711-2;B7Z5P7 O60711 LPXN Leupaxin 0 18684700.0 3077500.0 12092000.0 3515200.0 False True 4668792.495386931 9934088.124772783 2820419.1792331045 1.0 2.1277638992498176 0.604100349719946 22.154618038707703 -6.7084487771848895 1.8007357837312548 1.6944225862522906 0.6078421552505443 0.45772007255696745 0.47535073189738697 0.3782077295510691 2.3896733278215487 0.21014679543721007 0.5348779788195352 1.9568215514284033e-07 6.7084487771848895 -1.0865804310017464 TYCQPCFNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYCQPCFNK 9 0 O60711;O60711-2;B7Z5P7 O60711 LPXN Leupaxin 0 5723100.0 1823200.0 2055800.0 1844100.0 False True 2497286.310127401 1964967.9583785099 1408561.5604316683 1.0 0.7868412806372472 0.5640368726322812 21.251929802893784 -6.970567862492162 0.24425016182870857 1.075902304407448 0.2684974544599936 0.9999864761522204 0.0006545499692777553 0.07611891761008532 0.008368506097706988 0.005169418416130927 0.021560316795959645 1.0701191539230784e-07 6.970567862492162 -0.8074048499474544 TYCQPCFNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYCQPCFNK 9 0 O60711;O60711-2;B7Z5P7 O60711 LPXN Leupaxin 0 10327700.0 3077500.0 3485000.0 3765200.0 False True 3983884.416594277 3291056.68643879 3079972.234214478 1.0 0.8260924119009034 0.7731078294805223 21.925744360800152 -13.99996942863444 0.16649543946312487 1.8692583380465142 0.7245818841248514 0.9995208032721782 0.0021214986628472175 12.059217043362501 0.12913599106755952 3.3847721208874946 0.04461595025109382 1.0000703956482682e-14 13.99996942863444 -1.144676453921663 TYCQPCFNK(ub)LFPL ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYCQPCFNKLFPL 13 1 O60711;O60711-2;B7Z5P7 O60711 LPXN Leupaxin 1 5570900.0 1515300.0 3025700.0 1029900.0 True False 1986572.974186074 2574277.354086225 923335.827498394 1.0 1.2958383042238564 0.4647882758380407 20.921850359257956 -6.8104540926656565 1.4124933906436257 1.1611474671020465 0.45008126467904647 0.8610265916219018 0.12821566885427874 0.20619204861047924 0.8106919522137034 0.07137061409492552 0.16507122265106483 1.547198042714636e-07 6.8104540926656565 -0.7110662024230001 down TYCQPCFNK(ub)LFPL ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYCQPCFNKLFPL 13 1 O60711;O60711-2;B7Z5P7 O60711 LPXN Leupaxin 1 5756800.0 1515300.0 1637400.0 2604100.0 True False 2075547.3594427682 1565054.2538422847 1989065.2131229916 1.0 0.7540441063520045 0.9583328484766569 20.985060420780847 -10.042381041370415 6.136173681525863 1.0000001912834204 0.8561884775752593 0.39786244616592037 0.08340052973341953 2.182570049964289e-07 3.4023387262505576e-08 0.08075232277397863 0.02691740522686501 9.070243757547449e-11 10.042381041370415 -0.14381171370816115 TYCYLLPTFAFAHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYCYLLPTFAFAHK 14 0 F5H1S9;G8JLB3;Q9Y606-2;Q9Y606;F5GXL3 F5H1S9 PUS1 tRNA pseudouridine synthase;tRNA pseudouridine synthase A, mitochondrial 0 22284700.0 4207200.0 13218000.0 4859500.0 False True 5515679.9425827535 11245925.923360463 4356685.555615535 1.0 2.0389011038400615 0.7898727991775912 22.39510731358629 -6.6859202447928725 1.8807603991692226 1.6537979680726032 0.7943752431991982 0.3514379173623746 0.4397527983182026 0.4255163708354274 2.914898528008254 0.18726921435765695 0.49021219650073794 2.0610083685896601e-07 6.6859202447928725 -0.859422724873405 TYCYLLPTFAFAHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYCYLLPTFAFAHK 14 0 F5H1S9;G8JLB3;Q9Y606-2;Q9Y606;F5GXL3 F5H1S9 PUS1 tRNA pseudouridine synthase;tRNA pseudouridine synthase A, mitochondrial 0 8754300.0 6161000.0 1230400.0 1362900.0 False True 5965422.427360902 1721705.1364512371 1005915.6038764117 1.0 0.28861411868411774 0.1686243708849011 22.508192871918673 -13.999999999999998 0.2504171516685826 5.957777101617173 0.12056946625727082 0.9995434742728312 0.007839716532776046 14.014590285196652 0.15834881245384308 34.95937615034733 0.055246558581753646 1.0000000000000041e-14 13.999999999999998 -5.837207635359903 TYCYLLPTFAFAHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYCYLLPTFAFAHK 14 0 F5H1S9;G8JLB3;Q9Y606-2;Q9Y606;F5GXL3 F5H1S9 PUS1 tRNA pseudouridine synthase;tRNA pseudouridine synthase A, mitochondrial 0 30910200.0 8956200.0 11868000.0 10086000.0 False True 13587210.185925085 9750062.674892776 8092497.679149158 1.0 0.7175912156708086 0.5955967095829673 23.69574592722583 -13.999999999999998 0.11439230889892456 2.3536244620823794 0.3853163117243229 0.9997208399905986 0.0028298618822216507 11.988681701352945 0.10332371413380198 3.7196481188714094 0.1866247146255278 1.0000000000000041e-14 13.999999999999998 -1.9683081503580566 TYCYLLPTFAFAHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYCYLLPTFAFAHK 14 0 F5H1S9;G8JLB3;Q9Y606-2;Q9Y606;F5GXL3 F5H1S9 PUS1 tRNA pseudouridine synthase;tRNA pseudouridine synthase A, mitochondrial 0 28167200.0 4207200.0 10048000.0 13912000.0 False True 5762715.535304963 9604046.135707386 10626272.126633788 1.0 1.6665834148620942 1.8439695767615998 22.458317375109182 -11.129993658281027 0.24818369901877535 5.3110057055830826e-14 1.9302643916077693 0.999255687258629 0.009912426090385876 3.212418800725715 0.13408725616612388 1.8845346726542669 0.08206685386809388 7.41321066249754e-12 11.129993658281027 1.9302643916077162 TYCYLLPTFAFAHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYCYLLPTFAFAHK 14 0 F5H1S9;G8JLB3;Q9Y606-2;Q9Y606;F5GXL3 F5H1S9 PUS1 tRNA pseudouridine synthase;tRNA pseudouridine synthase A, mitochondrial 0 14619160.0 6161000.0 708860.0 7749300.0 False True 5123144.478577789 705041.2304823062 9369642.801285109 1.0 0.13761884589247994 1.8288851388954326 22.28859814735295 -6.7680753460142675 1.5816873643375338 0.5041517215036819 1.8377498086069344 0.7232132036825135 0.3632766155199052 0.2695408312478006 1.3304758063022233 0.18106420504148849 0.4317968857137418 1.7057864254041873e-07 6.7680753460142675 1.3335980871032524 TYCYLLPTFAFAHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYCYLLPTFAFAHK 14 0 F5H1S9;G8JLB3;Q9Y606-2;Q9Y606;F5GXL3 F5H1S9 PUS1 tRNA pseudouridine synthase;tRNA pseudouridine synthase A, mitochondrial 0 33858200.0 8956200.0 14304000.0 10598000.0 False True 11593977.45309559 13507969.825773455 8669272.74466296 1.0 1.1650850521679106 0.7477393137717604 23.46687224931828 -6.7993883757815965 1.4583091344971293 1.0911598360388164 0.7420599543007834 0.830358618949133 0.07068408667265548 0.221655713971466 0.9306824284019161 0.03813093270559895 0.08871566482931637 1.5871267966246134e-07 6.7993883757815965 -0.34909988173803297 TYDATTHFETTCDDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYDATTHFETTCDDIK 16 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 94957900.0 17420600.0 36555100.0 40982200.0 False True 22838575.301330365 31101221.5706638 36741755.0730213 1.0 1.36178466302371 1.6087586282530095 24.444969320612227 -7.689967575661068 0.07709468213063034 1.8324258677063937e-15 2.7998366353994086 0.9999982874456057 0.0003271022235007212 0.1398528101647568 0.008925595507296236 0.1417764091013619 0.17447076026072617 2.04189038610561e-08 7.689967575661068 2.799836635399407 TYDATTHFETTCDDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYDATTHFETTCDDIK 16 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 35943900.0 11641000.0 4869900.0 19433000.0 False True 11271462.82696125 6814476.466193002 14342914.322496383 1.0 0.6045778237313464 1.2724980370949053 23.426171426948866 -6.746284325598219 1.663422593534513 0.7664578050100382 1.27347289920235 0.6329180258534524 0.1661377799662258 0.30656265155823403 1.6676974452604392 0.07893613419090365 0.19240221134032448 1.7935590281882942e-07 6.746284325598219 0.5070150941923118 TYDATTHFETTCDDIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYDATTHFETTCDDIK 16 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 108551900.0 19676100.0 73179800.0 15696000.0 False True 29850082.215591498 60120292.933612935 12593678.720198812 1.0 2.0140746179322244 0.4218976225673776 24.83123156929836 -6.734641480604034 1.706142823891337 1.607105493842994 0.4219925456637871 0.5806268653253573 0.4261636616893641 0.3276504482801618 1.870482313616634 0.1977692315158707 0.4882240686958155 1.8422922255818795e-07 6.734641480604034 -1.1851129481792069 TYDATTHFETTCDDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYDATTHFETTCDDIK 16 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 68757400.0 17420600.0 27717500.0 23619300.0 False True 23861466.59401351 26492849.20048461 18040907.79475283 1.0 1.110277488439511 0.7560686902321011 24.50817938213512 -6.823065881991216 1.3585989871560158 1.059261053607048 0.7478180546207593 0.8912836848458806 0.04879773798271342 0.1895255814378133 0.6865399510151222 0.028219153964721033 0.06499220624867286 1.5029139584156388e-07 6.823065881991216 -0.3114429989862886 TYDATTHFETTCDDIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYDATTHFETTCDDIK 16 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 23936800.0 11641000.0 5498700.0 6797100.0 False True 9680007.283740308 5469077.411693502 8218342.183760462 1.0 0.5649869107929304 0.8490016528773658 23.206576702383142 -10.137429508458979 5.215757253138829 1.0000092879057207 0.7069942818349049 0.5866209807439189 0.1159485329233559 1.2523278941058404e-05 2.071151950401921e-06 0.11227024284756745 0.037422228085655915 7.287364481469264e-11 10.137429508458979 -0.2930150060708159 TYDATTHFETTCDDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYDATTHFETTCDDIK 16 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 48856100.0 19676100.0 14558000.0 14622000.0 False True 25471099.323915742 13747834.502489513 11960946.034389677 1.0 0.539742487265996 0.4695889204577483 24.60235789139081 -13.999999999999998 0.2648384202449087 4.456027704237371 0.4451121655917052 0.9995723553948879 0.004864920796720763 14.636502263486532 0.16287286664157571 27.15067744279731 0.02990802309083257 1.0000000000000041e-14 13.999999999999998 -4.010915538645666 TYDATTHFETTCDDIK(ub)NIYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYDATTHFETTCDDIKNIYK 20 1 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 1 32526400.0 5189600.0 13190800.0 14146000.0 True False 6803615.856157892 11222784.057335678 12682307.61801365 1.0 1.6495322920352766 1.8640540392260692 22.69787025558395 -10.984685457751473 0.21522351414384813 1.8276393691972258e-09 2.009948450387684 0.9993184317120879 0.00959030284109074 3.0155233748945176 0.11761051665131927 1.6185800400846393 0.12059780177294903 1.0358921506068454e-11 10.984685457751473 2.0099484485600447 TYDATTHFETTCDDIK(ub)NIYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYDATTHFETTCDDIKNIYK 20 1 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 1 40228000.0 13602400.0 14019500.0 12606100.0 True False 13170599.257577315 19617559.460726656 9304184.235106349 1.0 1.4894963453876462 0.7064359072161019 23.650817653410098 -6.73769987448339 1.6952481263068748 1.2920238582993968 0.7062149809585079 0.5945176546058126 0.2056793184073647 0.3219930020228111 1.8160753660388533 0.09601983326464628 0.2362097112510089 1.829363988002399e-07 6.73769987448339 -0.5858088773408889 TYDATTHFETTCDDIK(ub)NIYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYDATTHFETTCDDIKNIYK 20 1 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 1 125915300.0 36660300.0 38515000.0 50740000.0 True False 55616355.32693204 31641697.330931474 40711216.75986798 1.0 0.5689279195828405 0.732000803011155 25.72900586872989 -10.209371037778507 4.980482732537371 1.000040343813212 0.6504643612965902 0.8596635866747206 0.06657422588203711 2.9826791135611614e-05 4.734918070466225e-06 0.06446764281104937 0.021486739010446062 6.174886257464349e-11 10.209371037778507 -0.3495759825166217 TYDATTHFETTCDDIK(ub)NIYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYDATTHFETTCDDIKNIYK 20 1 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 1 34453000.0 5189600.0 13742200.0 15521200.0 True False 7108335.363666729 13135024.164621627 11855412.229148103 1.0 1.847834055742429 1.667818360082643 22.761080317106842 -10.074450225295422 4.563320744625786 0.9999581543621926 1.757826207827521 0.959398524254413 0.0734911001423658 25513374.042455807 0.7484328246126805 12140.924594932372 0.025157958307319327 8.424609407690734e-11 10.074450225295422 0.7578680534653285 TYDATTHFETTCDDIK(ub)NIYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYDATTHFETTCDDIKNIYK 20 1 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 1 43381600.0 13602400.0 15679900.0 14099300.0 True False 11310998.288493173 15595429.266483532 17047398.442202393 1.0 1.3787845129769816 1.5071524199190212 23.431222928844374 -12.162753001810577 0.17755368498088953 3.94287659890584e-09 1.622503850493446 0.9994741300141605 0.004937064074917011 5.737307384829575 0.11723290941117652 2.187941213444081 0.09694405830091068 6.874593105763774e-13 12.162753001810577 1.6225038465505692 TYDATTHFETTCDDIK(ub)NIYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYDATTHFETTCDDIKNIYK 20 1 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 1 102962700.0 36660300.0 27249600.0 39052800.0 True False 47457481.03254949 25733135.805676445 31945591.115566526 1.0 0.5422356021809702 0.6731413134560622 25.500132190822338 -10.504892131193683 9.294112565120933 1.0000098184474746 0.607688457818522 0.922930050661084 0.05344203284001234 1.0872908508127326e-05 5.791887832900878e-07 0.051746318135965155 0.017248341931403136 3.1268559101022425e-11 10.504892131193683 -0.3923213606289526 TYDLPGNFLTQALTQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYDLPGNFLTQALTQR 16 0 O94874;O94874-2;O94874-3 O94874 UFL1 E3 UFM1-protein ligase 1 0 5867300.0 3176400.0 2690900.0 0.0 False True 3075566.920673457 3765390.4028581167 0.0 1.0 1.2242914883587086 0.0 21.552420936933185 -6.906935063866626 1.2846027411618774 1.117094510614155 4.49862916080048e-23 0.9515203502388762 0.11718178873065649 0.1300518621468219 0.4303608109992721 0.07468202586675375 0.14777260902912434 1.2389818264492516e-07 6.906935063866626 -1.117094510614155 down TYDLPGNFLTQALTQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYDLPGNFLTQALTQR 16 0 O94874;O94874-2;O94874-3 O94874 UFL1 E3 UFM1-protein ligase 1 0 5862320.0 585220.0 1789400.0 3487700.0 False True 801591.6489758436 1710338.3912455009 2663977.0914362185 1.0 2.133677906239069 3.3233593374380312 19.612507952975054 -6.9705167434690605 0.24553175917221642 0.601078814360905 4.890606267835668 0.9999861368388376 0.00353194040503359 0.07613537798452615 0.008428061405207991 0.027358367510899356 0.1148713969073091 1.0702451206751693e-07 6.9705167434690605 4.289527453474763 TYDLYITYDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYDLYITYDK 10 0 Q9NT62;Q9NT62-2 Q9NT62 ATG3 Ubiquitin-like-conjugating enzyme ATG3 0 9295100.0 2920700.0 3644500.0 2729900.0 False True 3829065.9840990384 3100754.8061497305 2447436.135049869 1.0 0.8097940382919058 0.6391731417565893 21.868561090863054 -6.9724135395942035 0.19198352651351155 1.112682619673121 0.3316138385404881 0.9999955955667101 0.0003092471600318416 0.07552710092941889 0.0061390482660629445 0.005922946692967745 0.0184985253561738 1.0655809810157821e-07 6.9724135395942035 -0.7810687811326329 TYDLYITYDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYDLYITYDK 10 0 Q9NT62;Q9NT62-2 Q9NT62 ATG3 Ubiquitin-like-conjugating enzyme ATG3 0 12061700.0 4376000.0 2183100.0 5502600.0 False True 4237086.275301293 3054823.2147161034 4061303.9855384473 1.0 0.7209726251087204 0.9585134032347865 22.014641074396547 -10.109773755917562 6.684489801829098 1.0000001795183786 0.8397430145099927 0.37767247568727547 0.09697561658542277 2.594258684871291e-07 3.453702708260908e-08 0.09389634194248214 0.031298745668628114 7.766516050036184e-11 10.109773755917562 -0.16025716500838594 TYDLYITYDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYDLYITYDK 10 0 Q9NT62;Q9NT62-2 Q9NT62 ATG3 Ubiquitin-like-conjugating enzyme ATG3 0 8584400.0 2920700.0 2947500.0 2716200.0 False True 4000561.7189497133 2817269.703920935 2074689.5018949609 1.0 0.7042185327565865 0.5185995486752893 21.931771152385945 -9.07749407580731 0.10622472733794665 1.6246146317376733 1.3256837940988547e-09 0.9999533438907228 0.0013540630891522318 0.5409270018147775 0.03521066567993156 0.30871623970283507 0.20974195962255507 8.365770073896106e-10 9.07749407580731 -1.6246146304119895 TYDPSGDSTLPTCSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYDPSGDSTLPTCSK 15 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 6800900.0 1489800.0 2524200.0 2786900.0 False True 1953142.2272437226 2147599.199254537 2498538.321832478 1.0 1.0995610915059844 1.2792403374322714 20.897365579003594 -6.96200345012583 0.4062149841921376 0.9907750356254788 1.3946535345215956 0.9998374319507033 0.0014733130296226509 0.07899309614001912 0.018543152580534333 0.0023119429532942356 0.015020777611803647 1.0914316658538114e-07 6.96200345012583 0.4038784988961168 TYDPSGDSTLPTCSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYDPSGDSTLPTCSK 15 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 3021820.0 1448400.0 527020.0 1046400.0 False True 1402421.3348140756 737461.8343729933 772316.4486728869 1.0 0.5258489842289524 0.5507021531266678 20.419488418192806 -10.49556021286201 6.153622009784584 1.0003632880214917 0.5382755686778112 0.99783171413168 0.010146263715102048 5.0608073377747435e-05 4.148573723919358e-06 0.00983154527716741 0.0032746925329015493 3.194771394259235e-11 10.49556021286201 -0.4620877193436804 TYDPSGDSTLPTCSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYDPSGDSTLPTCSK 15 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 15745400.0 3028100.0 10655000.0 2062300.0 False True 4593849.083763175 8753532.002105022 1654685.5010617995 1.0 1.9054896759765412 0.3601958773330706 22.13127203168155 -6.747879934795788 1.6576029800152479 1.5337849792507927 0.3575966737464588 0.6398457907136803 0.380459892774824 0.3037516754554066 1.6413948760805632 0.1813629584999534 0.4412999739371703 1.7869815361084096e-07 6.747879934795788 -1.1761883055043338 TYDPSGDSTLPTCSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYDPSGDSTLPTCSK 15 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 5182300.0 1489800.0 1418400.0 2274100.0 False True 2040619.3203311793 1355730.3979784397 1737004.416559654 1.0 0.6643720288595589 0.8512143344196846 20.960575640526486 -10.12749551168079 5.11724243648669 1.0000083055632851 0.7577931829719161 0.6914135471890912 0.07627805183253102 7.228085487220018e-06 1.232405861733006e-06 0.07385843833927747 0.024618635368860695 7.455975775427657e-11 10.12749551168079 -0.24221512259136901 TYDPSGDSTLPTCSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYDPSGDSTLPTCSK 15 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 7685800.0 3028100.0 1835600.0 2822100.0 False True 3919935.142774699 1733447.2463779203 2308506.7571912967 1.0 0.4422132467097177 0.588914528712645 21.902398353774 -10.397718163010676 8.972190288459075 1.0000019118299532 0.5155638877112927 0.9356470974448545 0.05989054758655217 2.2903857590078666e-06 1.5370991294071735e-07 0.05798900224565264 0.019329591116496615 4.0020437960111614e-11 10.397718163010676 -0.48443802411866055 TYEAALETIQNMSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYEAALETIQNMSK 14 0 O00231;O00231-2 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 12925500.0 4434400.0 2692200.0 5798900.0 False True 4293632.399267837 3767209.4996375274 4279994.126728979 1.0 0.8773945110624568 0.9968236049874265 22.033767249003603 -10.697662334844344 7.2438513961058275 1.0004059747114167 0.9371090580253069 0.2699336314708082 0.048756723426517004 0.00032172174417139824 1.3427710291188415e-05 0.04751116140243009 0.01573616482054513 2.0060311159057053e-11 10.697662334844344 -0.06329691668610982 TYEAALETIQNMSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYEAALETIQNMSK 14 0 O00231;O00231-2 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 10111900.0 1656500.0 4685600.0 3769800.0 False True 2268952.8152292944 4478574.698792853 2879450.8814680916 1.0 1.973850962758016 1.269066003550674 21.113595176596867 -10.06858579079815 4.524652430057666 0.9999641676177272 1.6214584829486463 0.5090077298276774 0.2877272548544598 44607611.65158005 49632058.27255157 13593.379441377661 0.09849669187478362 8.53914148032407e-11 10.06858579079815 0.621494315330919 TYEAALETIQNMSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYEAALETIQNMSK 14 0 O00231;O00231-2 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 9900500.0 4434400.0 2789700.0 2676400.0 False True 3687400.0772285857 2774671.332387907 3236022.865724577 1.0 0.7524736329867746 0.8775893035606651 21.81417252443788 -10.15087000229111 4.884082368350311 1.000013178832036 0.8150314682730363 0.7445163001066111 0.05107825862439129 71467917.84663102 0.650576603071438 10592.214147721008 0.017485446528806726 7.065290084978797e-11 10.15087000229111 -0.1849817105589998 TYEEGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYEEGLK 7 0 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 5851700.0 1877600.0 1563500.0 2410600.0 False True 1817996.6157462776 2187813.7035447895 1779191.5435501342 1.0 1.2034201189349871 0.9786550360655022 20.7939180832398 -6.668369772690288 1.943243359625845 1.1300230581929056 0.9795710425518285 0.2718488288039549 0.08644084622591348 0.464844337454926 3.3825823112199482 0.03583197816781897 0.09593486704122672 2.1460025185064391e-07 6.668369772690288 -0.15045201564107713 TYEEGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYEEGLK 7 0 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 6137300.0 1706900.0 1913800.0 2516600.0 False True 2337987.0572380796 1829241.9879097154 1922230.9110039256 1.0 0.7824003910742957 0.8221734611630841 21.156835512662468 -10.31095770733942 5.640925437457949 1.0000256566052397 0.802286926118692 0.9705433265249349 0.016237287870254698 5.239871437008394e-06 6.400705020153703e-07 0.01572372486734173 0.005240562125754926 4.88699947823789e-11 10.31095770733942 -0.19773873048654766 TYEEGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYEEGLK 7 0 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 4507200.0 1877600.0 1593300.0 1036300.0 False True 1561307.5917834193 1584716.5766547106 1252985.538690174 1.0 1.014993192241224 0.8025231833138906 20.574323358674075 -6.889964431458903 1.0226166931224283 1.01142603998108 0.7842631232904077 0.9808746659992624 0.013389531719979218 0.11917106650583936 0.22202791281898845 0.009977149087824612 0.02486945954051477 1.28835506312708e-07 6.889964431458903 -0.22716291669067223 TYEEGLK(ub)HEANNPQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYEEGLKHEANNPQLK 16 1 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 26129000.0 11339000.0 11512000.0 3278000.0 True False 14865538.807032213 9794454.473424539 2938824.004796325 1.0 0.6588697927848552 0.19769374275260718 23.825468419427885 -7.376988877007703 0.4217399625056769 1.0278325973163662 4.491332232221517e-25 0.9990855848514927 0.009941471288191043 0.10977841927308647 0.04176761565878232 0.014775289105564133 0.0588341276870126 4.197697348430923e-08 7.376988877007703 -1.0278325973163662 down TYEEGLK(ub)HEANNPQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYEEGLKHEANNPQLK 16 1 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 41101700.0 19287000.0 14325000.0 7489700.0 True False 18674744.742170043 20045047.203888126 5527922.883816256 1.0 1.07337730612316 0.2960106261229625 24.15458518772285 -6.883771505799124 1.0585020411950443 1.0482153374886052 0.23676527593310237 0.9766040501622126 0.05360262632373154 0.1243434413244345 0.2525220433804292 0.03886608786483033 0.09496000532647572 1.3068582811600862e-07 6.883771505799124 -0.8114500615555028 down TYEEGLK(ub)HEANNPQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYEEGLKHEANNPQLK 16 1 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 48021300.0 24695000.0 14685000.0 8641300.0 True False 37464120.446329944 12064347.015571319 6933343.267383661 1.0 0.322024029173576 0.18506622295633968 25.15900624560169 -13.999999999999986 0.2248436935507734 5.180245712712256 0.11512283995746588 0.9995032024878606 0.00794147855040104 13.135934424948736 0.15017750805902233 24.444527172299956 0.07344594697451912 1.0000000000000327e-14 13.999999999999986 -5.06512287275479 TYEEGLK(ub)HEANNPQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYEEGLKHEANNPQLK 16 1 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 25648800.0 11339000.0 9776800.0 4533000.0 True False 15531334.724953191 9344828.648445873 3462398.7600654787 1.0 0.6016758259309254 0.22292989117687784 23.888678480950777 -7.651582738975233 0.33410265690541224 1.074848003277069 4.1068069847185856e-20 0.9992883568754118 0.008463725091322032 0.12394203333027272 0.0458344018018912 0.02897140458050276 0.07444451579261624 2.230577211858774e-08 7.651582738975233 -1.074848003277069 down TYEEGLK(ub)HEANNPQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYEEGLKHEANNPQLK 16 1 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 43867500.0 19287000.0 21675000.0 2905500.0 True False 16037995.058972528 21558232.472849376 3513026.616485857 1.0 1.3441974756556947 0.21904400167030094 23.934990463157128 -6.824574364329115 1.3517941432692815 1.1847082257427062 0.19194245273947236 0.8946420320470889 0.15279580837127035 0.18758259197378066 0.6722281262150304 0.08879123654483354 0.20446101213666187 1.4977027791475376e-07 6.824574364329115 -0.9927657730032338 down TYEEGLK(ub)HEANNPQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYEEGLKHEANNPQLK 16 1 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 1 50667400.0 24695000.0 18374000.0 7598400.0 True False 31968164.31122528 17351470.7479559 6215569.166167878 1.0 0.5427734473281318 0.19442996806624105 24.93013256769414 -8.02184537838167 0.31443035402032965 1.1145560453874077 1.1130212800624326e-11 0.9989969554282868 0.010447348173684463 0.09695787118303446 0.0627968066164063 0.058501120740979164 0.08927090825870812 9.50943297197411e-09 8.02184537838167 -1.1145560453762775 down TYEEGLKHEANNPQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYEEGLKHEANNPQLK 16 1 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 30183900.0 5270900.0 14697600.0 10215400.0 False True 6910200.943468211 12504775.370796073 9158408.401036099 1.0 1.8096109611133768 1.3253461767552477 22.72029623303901 -10.136536536429281 6.5273621569821385 0.9999986901922384 1.5674785689343125 0.646759270324841 0.19770027034606014 3.7735856378886304e-06 4.994862536579389e-07 0.19142290569776518 0.06380748788258252 7.302363767898722e-11 10.136536536429281 0.5674798787420741 TYEEGLKHEANNPQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYEEGLKHEANNPQLK 16 1 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 32576100.0 9277800.0 6571600.0 16726700.0 False True 8983281.317410953 9195674.15044128 12345475.479756104 1.0 1.0236431238793198 1.3742723892915065 23.098811082850663 -6.920563049924715 0.8205244114762841 0.9924197494101059 1.4315563579813848 0.9943362957214672 0.012879083727361455 0.09784144072888178 0.1039005209289955 0.011129903090307227 0.03352172809263836 1.2007067443769318e-07 6.920563049924715 0.4391366085712789 TYEEGLKHEANNPQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYEEGLKHEANNPQLK 16 1 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 153901100.0 23307100.0 112479000.0 18115000.0 False True 35358574.677248694 92406243.64756185 14534562.309913462 1.0 2.613404089136551 0.4110618836472969 25.075556784316735 -6.710343385151934 1.7937904185660045 1.9915579707267568 0.41615683272275333 0.466715955088602 0.679847964918366 0.37444123897935483 2.3487893479816284 0.30156695991208654 0.7658575346332773 1.9483035185678442e-07 6.710343385151934 -1.5754011380040034 TYEEGLKHEANNPQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYEEGLKHEANNPQLK 16 1 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 29418800.0 5270900.0 11404900.0 12743000.0 False True 7219694.170716618 10900993.807039142 9733365.850323068 1.0 1.5098968944216542 1.3481687201934407 22.783506294561903 -10.00953582526824 4.725400986323955 0.9999919135772734 1.4290328072628744 0.9036900556086399 0.06602525070634103 45547629.807029285 1.893682621525776 4438.780445155769 0.022602199476786385 9.782822522402716e-11 10.00953582526824 0.42904089368560105 TYEEGLKHEANNPQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYEEGLKHEANNPQLK 16 1 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 19944500.0 9277800.0 7137300.0 3529400.0 False True 7714901.776229335 7098849.94825688 4267381.221898195 1.0 0.9201478066939757 0.5531348739975639 22.87921635828494 -6.941701098049162 0.6435542603895857 1.004029218343503 0.44900919764450314 0.9983781929297786 0.007836184162408492 0.08699939090072259 0.0511416373983326 0.007730024425472338 0.03135899185281729 1.1436651883203076e-07 6.941701098049162 -0.5550200206989997 TYEEGLKHEANNPQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYEEGLKHEANNPQLK 16 1 P31948;P31948-2;F5H783;F5GXD8 P31948 STIP1 Stress-induced-phosphoprotein 1 0 62817500.0 23307100.0 18936100.0 20574300.0 False True 30171500.401626185 17882289.38883032 16829988.510145262 1.0 0.5926881046945381 0.5578107911808774 24.846683106409184 -13.999999999999998 0.34806997033319625 5.949806499666247 0.5528683791630268 0.9997510143353344 0.0031674477372685876 20.46911724306494 0.18978136129916068 74.8431417311103 0.010475110014444433 1.0000000000000041e-14 13.999999999999998 -5.39693812050322 TYFNILIKPETLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYFNILIKPETLAK 14 1 O43847-2;G3V1R5;O43847;F5H7V1;H0Y5G9 O43847-2 NRD1 Nardilysin 0 12564100.0 3102600.0 3704500.0 5757000.0 False True 4067538.645621142 3151803.0400278987 5161320.865043451 1.0 0.7748673865510616 1.2689051819089185 21.955724622310143 -6.7827792816011945 1.524748645266095 0.8729847887844424 1.2731859420096967 0.7771949233146633 0.09532670208437186 0.24628012542222016 1.1310317855632643 0.04923012063784364 0.1159098273459478 1.6490002382757107e-07 6.7827792816011945 0.4002011532252543 TYFNILIKPETLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYFNILIKPETLAK 14 1 O43847-2;G3V1R5;O43847;F5H7V1;H0Y5G9 O43847-2 NRD1 Nardilysin 0 8301400.0 3752200.0 1632900.0 2916300.0 False True 3633088.464850444 2284925.4854610055 2152433.5428753286 1.0 0.6289209601052378 0.5924528300644982 21.792765064790526 -13.999999999999998 0.328004537099394 4.991235532595612 0.5858424841244508 0.9997106843038484 0.0031318603249527875 18.6561505110331 0.18303506544753415 51.31442265100411 0.01177412731606275 1.0000000000000041e-14 13.999999999999998 -4.4053930484711605 TYFNILIKPETLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYFNILIKPETLAK 14 1 O43847-2;G3V1R5;O43847;F5H7V1;H0Y5G9 O43847-2 NRD1 Nardilysin 0 34124500.0 5346000.0 9229500.0 19549000.0 False True 8110272.84495159 7582423.614587362 15685131.581368908 1.0 0.9349159713297687 1.9339832187190162 22.95131901957896 -6.8913447453018195 1.0144288070541787 0.9480364684940552 2.0221993997848986 0.9817439161631941 0.0616663118086776 0.11805748806957052 0.21554574525053985 0.04623598755714166 0.11583541273606898 1.2842667973013813e-07 6.8913447453018195 1.0741629312908434 TYFNILIKPETLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYFNILIKPETLAK 14 1 O43847-2;G3V1R5;O43847;F5H7V1;H0Y5G9 O43847-2 NRD1 Nardilysin 0 11668000.0 3102600.0 3005000.0 5560400.0 False True 4249715.064612377 2872229.163793861 4247148.0400326755 1.0 0.6758639391405507 0.9993959537190911 22.018934683833034 -10.972230154555499 9.431687446539069 1.0888360937237285 0.8376299464492911 0.25140027260881603 0.13208139186201875 0.08139611030447416 0.00023965557306738567 0.04218993913689686 0.04262908591879122 1.0660310278863233e-11 10.972230154555499 -0.25120614727443735 TYFNILIKPETLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYFNILIKPETLAK 14 1 O43847-2;G3V1R5;O43847;F5H7V1;H0Y5G9 O43847-2 NRD1 Nardilysin 0 8578700.0 3752200.0 1256100.0 3570400.0 False True 3120120.550644309 1249333.1399836706 4316954.13233561 1.0 0.4004118173336866 1.3835856859582407 21.573170340224802 -6.741617133149802 1.6807013380655842 0.6439394224714201 1.384385754751024 0.6123359089252969 0.2519117449204425 0.31483490295051186 1.7468030174288944 0.11854394862030634 0.2903897730082427 1.8129376442456386e-07 6.741617133149802 0.740446332279604 TYFNILIKPETLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYFNILIKPETLAK 14 1 O43847-2;G3V1R5;O43847;F5H7V1;H0Y5G9 O43847-2 NRD1 Nardilysin 0 24668300.0 5346000.0 15574000.0 3748300.0 False True 6920502.385414457 14707293.209353734 3066147.860805828 1.0 2.1251771027997326 0.44305278577289325 22.72244534167141 -6.726400131985193 1.7360558831574198 1.6797983253108046 0.44462561761848807 0.5426916278036669 0.47314421955619784 0.3429966323140476 2.0234435046752606 0.21611461913352237 0.5385346602037888 1.8775861283074353e-07 6.726400131985193 -1.2351727076923167 TYFSCTSAHTSTGDGTAMITR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TYFSCTSAHTSTGDGTAMITR 21 0 P31040-2;P31040;D6RFM5;A0A494C1T6 P31040-2 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0 25629700.0 4113300.0 9677200.0 11839200.0 False True 5392576.1332538575 8233399.481430157 10614193.153625568 1.0 1.5268026408858801 1.9682973204906815 22.362543209053424 -6.973162511764104 0.16609003691098298 0.5887694901794648 2.9181103048426893 0.9999977126555486 0.0005986042308051592 0.07528922032958314 0.0051593264691006425 0.019291861414219392 0.05183724119671486 1.0637448934164825e-07 6.973162511764104 2.3293408146632246 TYFSCTSAHTSTGDGTAMITR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TYFSCTSAHTSTGDGTAMITR 21 0 P31040-2;P31040;D6RFM5;A0A494C1T6 P31040-2 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0 18670500.0 4113300.0 4867300.0 9689900.0 False True 5634098.167752874 4652246.591991306 7401345.189754804 1.0 0.8257304813428245 1.3136699023309324 22.425753270576315 -6.810118542914734 1.413908147740131 0.9050377616072139 1.3222399891546486 0.8601712012018932 0.07549488052490572 0.20663613917111567 0.8141311833788251 0.0419829446796402 0.09711570918397874 1.5483939191341703e-07 6.810118542914734 0.41720222754743463 TYFSCTSAHTSTGDGTAMITR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYFSCTSAHTSTGDGTAMITR 21 0 P31040-2;P31040;D6RFM5;A0A494C1T6 P31040-2 SDHA Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial 0 13141700.0 3944000.0 5854800.0 3342900.0 False True 5105585.747862817 5528975.2332171695 2734526.5010505575 1.0 1.0829267210978843 0.5355950592339423 22.283645055806243 -6.868292070435806 1.1431575585002876 1.0464449924518389 0.5045729723994077 0.9629452340072674 0.04636457158403567 0.1384995146088688 0.3393498056196073 0.03150918541137567 0.07438249593841044 1.3542783307834726e-07 6.868292070435806 -0.5418720200524312 TYGGCEGPDAMYVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYGGCEGPDAMYVK 14 0 E5RHG8;Q15369;R4GMY8 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 0 10750300.0 1985600.0 3634800.0 5129900.0 False True 2603140.8285777536 3092502.0083394265 4599107.157475484 1.0 1.187988745898561 1.7667531110824464 21.311821932235954 -6.95086691965579 0.5492438563660642 0.9919597567472169 1.9899363612833438 0.9992675707987616 0.00883067103713373 0.0831394867196107 0.03453606510073782 0.0095939381604138 0.04800658784546415 1.1197809640554101e-07 6.95086691965579 0.9979766045361269 TYGGCEGPDAMYVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYGGCEGPDAMYVK 14 0 E5RHG8;Q15369;R4GMY8 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 0 35638100.0 4961300.0 26000000.0 4676800.0 False True 7526654.819614355 21360096.86107278 3752428.430085739 1.0 2.8379269905414914 0.49855194904208494 22.843577378782374 -6.69718270354001 1.8408232902864157 2.14441602692803 0.5058536156615496 0.4042415810873041 0.7762197220441301 0.4014233157224697 2.6425333304317844 0.336646705099186 0.8688200969236642 2.0082477842141423e-07 6.69718270354001 -1.6385624112664805 TYGGCEGPDAMYVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYGGCEGPDAMYVK 14 0 E5RHG8;Q15369;R4GMY8 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 0 12071200.0 1985600.0 4548200.0 5537400.0 False True 2719729.9788223864 4347245.48511389 4229580.166332804 1.0 1.598410694798533 1.555147091537435 21.375031993758846 -10.219508990475841 4.972843619002295 0.9999241917816374 1.5767788931685507 0.9957979694803699 0.017662292072811746 1.484775599700927e-05 2.3303434275215597e-06 0.01710367547979003 0.005700480254178575 6.032412198983823e-11 10.219508990475841 0.5768547013869133 TYGGCEGPDAMYVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYGGCEGPDAMYVK 14 0 E5RHG8;Q15369;R4GMY8 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 0 14771300.0 4961300.0 4644500.0 5165500.0 False True 6422500.651843765 4386029.492156372 4225432.002505812 1.0 0.682916161463874 0.6579107160219251 22.614703700874824 -13.999999999999998 0.3601116994380646 5.151686502968573 0.6549046571876306 0.9997734911649637 0.002343364902297612 21.70894728055512 0.1939496789529456 69.27030006029129 0.007213106053711055 1.0000000000000041e-14 13.999999999999998 -4.4967818457809425 TYGNVLVLDGVIQCTER ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYGNVLVLDGVIQCTER 17 0 P19623;K7ESL0 P19623 SRM Spermidine synthase 0 34424400.0 6632800.0 20574000.0 7217600.0 False True 10062442.522632789 16902408.95460429 5791038.196413536 1.0 1.6797520996106876 0.575510188842136 23.262477206688533 -6.740183426298549 1.6863034818845335 1.4043687836546057 0.5748720237326874 0.6056581767694565 0.28560045847893684 0.31747880369097264 1.772754509013409 0.13398855887856773 0.3286942637246416 1.8189324617506844e-07 6.740183426298549 -0.8294967599219183 TYGNVLVLDGVIQCTER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYGNVLVLDGVIQCTER 17 0 P19623;K7ESL0 P19623 SRM Spermidine synthase 0 9545900.0 2559400.0 2340200.0 4646300.0 False True 3505679.3451843364 2236802.225993473 3548939.63355223 1.0 0.6380510040275394 1.0123400585473736 21.74126261212201 -10.97348524576805 11.39904936283734 1.0871584580538294 0.8251955312875039 0.22530076667585563 0.15280286664705792 0.08186956986380456 0.00019043250999051676 0.03578725034533346 0.04931691314806734 1.0629546942887668e-11 10.97348524576805 -0.2619629267663255 TYGQSTYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYGQSTYSR 9 0 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 0 7574200.0 1578000.0 3313500.0 2682700.0 False True 2068773.281373737 2819138.7159218392 2405119.9382755 1.0 1.3627103275666022 1.1625826570412865 20.980344117006418 -10.181725365301116 4.317981852067319 0.9999263872999559 1.2626464922615934 0.696648550414101 0.08170177942958104 8739474.836302396 20607535.459873997 3697.3699569102196 0.027968693014997513 6.580738518102225e-11 10.181725365301116 0.26272010496163756 TYGQSTYSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYGQSTYSR 9 0 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 0 6785200.0 2363100.0 1974900.0 2447200.0 False True 2288084.68399554 2763487.868967447 1806204.9055736705 1.0 1.2077734221540002 0.7893960036564763 21.125709017821382 -6.77164624144629 1.5679426132394894 1.1189190543117173 0.7868821954729708 0.7369225600609476 0.08760678173145002 0.2637591782534657 1.2799038223894812 0.04403333613952027 0.10466909195091316 1.6918184567710486e-07 6.77164624144629 -0.33203685883874656 TYGQSTYSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYGQSTYSR 9 0 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 0 33466500.0 8479800.0 17143000.0 7843700.0 False True 12864476.556419868 14083697.711129641 6293389.256984165 1.0 1.0947742529097568 0.48920678811789836 23.616889420558756 -6.866896827753167 1.1503191966345814 1.052720514403421 0.4557623912228823 0.9614902939298066 0.05219134203864889 0.13986856529056504 0.3478469927410196 0.035272630376782896 0.083092127850107 1.3586361697701713e-07 6.866896827753167 -0.5969581231805388 down TYGQSTYSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYGQSTYSR 9 0 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 0 5610400.0 1578000.0 1915000.0 2117400.0 False True 2161429.2438465566 1830388.967941846 1617313.7292218525 1.0 0.846841955688737 0.7482612414106248 21.04355417852931 TYGQSTYSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYGQSTYSR 9 0 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 0 6578290.0 2363100.0 3232100.0 983090.0 False True 1965022.353080206 3214688.035778382 1188649.573705414 1.0 1.6359549451126107 0.6049038433797893 20.90611429325566 -6.739845514955114 1.6872332396301297 1.3784635708113886 0.60432025550406 0.6042284835599325 0.2672030073437862 0.3181126848320622 1.7780674660153388 0.1252863211248812 0.3074969262001369 1.8203482685706235e-07 6.739845514955114 -0.7741433153073286 TYGQSTYSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYGQSTYSR 9 0 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 0 23650000.0 8479800.0 6797900.0 8372300.0 False True 10977268.261847667 6419590.889165635 6848627.30705244 1.0 0.5848076894938801 0.623891768305906 23.388015742651206 -9.828548379796002 6.5741901192046655 1.0000000078697469 0.6043497294521512 0.9927344044452697 0.015956008359518308 1.8504090389861347e-09 3.32668265092806e-10 0.015449339122447992 0.005149779554007346 1.4840605485928064e-10 9.828548379796002 -0.3956502784175957 TYGVSFFLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYGVSFFLVK 10 0 Q9Y490;Q9Y4G6 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 11673900.0 7756300.0 3917600.0 0.0 False True 7510080.502083972 5481918.110014107 0.0 1.0 0.7299413246626224 0.0 22.84039694168887 -7.370807090433104 0.7765485161884325 0.9897933397770068 1.8955008106437144e-17 0.9876592185387213 0.04692329495824087 0.11075281804115086 0.1382933185517718 0.040431523563627045 0.07217080433311075 4.2578750198046984e-08 7.370807090433104 -0.9897933397770068 down TYGVSFFLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYGVSFFLVK 10 0 Q9Y490;Q9Y4G6 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 75815000.0 23426000.0 21554000.0 30835000.0 False True 35538954.67000305 17707520.297829334 24740448.734539386 1.0 0.498256644356946 0.6961501531000789 25.082897911290516 -10.168498533411572 5.3449076393423045 1.0000144806233193 0.5972033987283923 0.8467178797402495 0.08078968663870183 1.3941194333450737e-05 2.1687714603430997e-06 0.0782270867511313 0.026074759241356327 6.784244114960797e-11 10.168498533411572 -0.402811081894927 TYGVSFFLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYGVSFFLVK 10 0 Q9Y490;Q9Y4G6 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 18301000.0 7756300.0 4790600.0 5754100.0 False True 6449707.112350739 4764792.086940356 6957255.706047591 1.0 0.7387610016920166 1.078693277827288 22.620802217123146 -6.7014477950562386 1.8261315210797788 0.8380078748100072 1.0776958254539537 0.42427783359047855 0.11024358644946333 0.3925076472689695 2.5458178676705394 0.04814835349748933 0.12358453271654797 1.988621840953854e-07 6.7014477950562386 0.23968795064394655 TYGVSFFLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYGVSFFLVK 10 0 Q9Y490;Q9Y4G6 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 80331000.0 23426000.0 35474000.0 21431000.0 False True 30325418.795495585 33499840.715847835 17530777.900629565 1.0 1.104678584713355 0.5780885671802665 24.854024233382965 -6.855041715976807 1.2105043826988544 1.056202485487034 0.5548968124155897 0.9473289250416399 0.05223730155063591 0.15199509092091573 0.42606500542718456 0.03371850826830075 0.07832167873390504 1.3962342399122242e-07 6.855041715976807 -0.5013056730714442 TYHALSNLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYHALSNLPK 10 0 O00231;O00231-2;J3QS13 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 4289700.0 2281700.0 2008000.0 0.0 False True 2209268.6824394334 2809804.871581666 0.0 1.0 1.2718257828554975 0.0 21.075137453500012 -6.891344283647595 1.3161610728749793 1.1415815394656808 4.5378064391973144e-18 0.940236961680946 0.13368621578246392 0.14047436056635157 0.4888095934440337 0.08270931245453507 0.16641165161988275 1.2842681624753168e-07 6.891344283647595 -1.1415815394656808 down TYHLTSAGEK(ub)LTEDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYHLTSAGEKLTEDR 15 1 B8ZZ06;Q4TT61;Q9BV90 B8ZZ06 C16orf33;SNRNP25 U11/U12 small nuclear ribonucleoprotein 25 kDa protein 1 17075700.0 5031200.0 2561600.0 9482900.0 True False 6512987.579778768 2419044.708172626 7757109.502770758 1.0 0.3714185968484214 1.1910216943841079 22.634888044791776 -6.701770943083828 1.8243133894483519 0.6103644188415114 1.1886870447495628 0.4261145185884694 0.2652458666655279 0.3918405875827319 2.5364980861022626 0.11593327588957474 0.29752635351746437 1.987142705867267e-07 6.701770943083828 0.5783226259080514 TYHVGEQWQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYHVGEQWQK 10 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 29488300.0 9151200.0 11793100.0 8544000.0 False True 11997311.820346847 10033615.449143747 7659948.839835191 1.0 0.8363219694037819 0.638472097294687 23.516207848552867 -6.9685959630791885 0.28976781667845025 1.0387660437650343 0.4299172753141324 0.9999692632860253 0.0008194639453706978 0.07676098723821077 0.01065267112953997 0.0034608556534757415 0.017946733237139613 1.0749890411769831e-07 6.9685959630791885 -0.608848768450902 TYHVGEQWQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYHVGEQWQK 10 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 26243300.0 9745300.0 7429900.0 9068100.0 False True 9435940.785807518 10396697.816416647 6692892.572831242 1.0 1.1018188914510985 0.7092978564361001 23.169734934458365 -6.837817886909486 1.2923802845366175 1.0541920725667244 0.6969267235782817 0.9206529397906603 0.0468487623551291 0.17136437886868466 0.5569102131983004 0.02843361024509951 0.0654762170110246 1.4527206605273662e-07 6.837817886909486 -0.35726534898844275 TYHVGEQWQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYHVGEQWQK 10 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 26875500.0 10346500.0 13424300.0 3104700.0 False True 15696396.93046982 11028628.780465357 2491054.6841616514 1.0 0.7026216799510594 0.15870232481990948 23.90393009421337 -7.280783035482065 0.5145635069959239 1.0093804039927472 3.858022075735606e-24 0.9984810772686444 0.013575960759921913 0.09768435626177317 0.048418368662862914 0.01461722289228421 0.055260324248228104 5.2386208185769403e-08 7.280783035482065 -1.0093804039927472 down TYHVGEQWQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYHVGEQWQK 10 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 28828800.0 9151200.0 9365600.0 10312000.0 False True 12534645.941881238 8951796.824102433 7876517.982306477 1.0 0.7141643143020376 0.6283797738545732 23.579417910075758 -13.999999999999998 0.16865683301885287 2.436479334581806 0.5516157400261285 0.9995163046906047 0.0034940774249413472 12.078758944968557 0.13002145181170788 5.675924297317892 0.07080380322992497 1.0000000000000041e-14 13.999999999999998 -1.8848635945556778 TYHVGEQWQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYHVGEQWQK 10 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 25203100.0 9745300.0 11598400.0 3859400.0 False True 8103648.739990921 11535917.117097862 4666382.696150581 1.0 1.4235460453966797 0.575837236518202 22.95014020989264 -6.770873794655987 1.571285394346621 1.2426638362520854 0.5709306886699087 0.7338360485239303 0.1785441918039712 0.2650153045108705 1.2914459604607258 0.08956233175453239 0.2130097175189485 1.694830244093048e-07 6.770873794655987 -0.6717331475821767 TYHVGEQWQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYHVGEQWQK 10 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 19924500.0 10346500.0 5816800.0 3761200.0 False True 13393748.210005745 5493089.966621851 3076700.1931710127 1.0 0.4101234307599019 0.22971166434744356 23.675056416305818 -13.999999999999748 0.16594146943695326 3.9444918992342473 0.0634916343836864 0.999522014826934 0.007191693322210095 12.054616718677849 0.12890758424675067 11.422719867510269 0.15270581704579883 1.0000000000005808e-14 13.999999999999748 -3.881000264850561 TYHYHCALHDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYHYHCALHDK 11 0 Q5JRC6;A0A0D9SGE8;Q8IWS0-5;Q8IWS0-3;Q8IWS0;Q8IWS0-4;Q8IWS0-2 Q5JRC6 PHF6 PHD finger protein 6 0 7190200.0 3042900.0 1371500.0 2775800.0 False True 3939094.0345263104 1295174.819354607 2270632.882113179 1.0 0.3288001779095269 0.5764353077664546 21.90943242687666 -10.260773490291523 5.577615373237273 1.0000412258454898 0.4526177428380975 0.8669278174707273 0.10109661842294232 5.183105439174713e-05 6.869157172635808e-06 0.09789372556285063 0.032628793292487156 5.485629976761547e-11 10.260773490291523 -0.5474234830073923 TYHYHCGVQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYHYHCGVQDK 11 0 Q5JRC6;A0A0D9SGE8;Q8IWS0-5;Q8IWS0-3;Q8IWS0 Q5JRC6 PHF6 PHD finger protein 6 0 11552300.0 2467000.0 4788400.0 4296900.0 False True 3234260.890461987 4073989.3850370105 3852298.0067752628 1.0 1.259635361220064 1.1910906810690198 21.625004627293084 -10.085675619401764 4.380440516559087 0.9999781121190785 1.2253630211393358 0.9351200021011307 0.02798324856017669 19451133.35829009 0.3126107649851109 4369.3325236194205 0.0095794102828252 8.209645052117524e-11 10.085675619401764 0.22538490902025732 TYHYHCGVQDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYHYHCGVQDK 11 0 Q5JRC6;A0A0D9SGE8;Q8IWS0-5;Q8IWS0-3;Q8IWS0 Q5JRC6 PHF6 PHD finger protein 6 0 6364220.0 3720800.0 1713500.0 929920.0 False True 3602685.2406629473 2397709.485784457 686346.0549979848 1.0 0.6655339907916138 0.1905095808124739 21.78064118124124 -7.359041505176088 0.4372735323275956 1.0236039132565493 1.0397378764701085e-12 0.9989929654215248 0.010539734356292404 0.10762887562863603 0.04280028051609027 0.014446281670245989 0.05806321707215265 4.374802935187768e-08 7.359041505176088 -1.0236039132555095 down TYHYHCGVQDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYHYHCGVQDK 11 0 Q5JRC6;A0A0D9SGE8;Q8IWS0-5;Q8IWS0-3;Q8IWS0 Q5JRC6 PHF6 PHD finger protein 6 0 11052900.0 2897300.0 5437700.0 2717900.0 False True 4395415.92100229 4467299.950055983 2180705.87370211 1.0 1.0163543178496977 0.496131859395195 22.067568257736415 -6.8996397384642165 0.9635209524316712 1.0218432662336858 0.44191937585389734 0.9863868514158414 0.028173933339385095 0.11167168945980414 0.1789098101265077 0.0219449651230469 0.05699590618178796 1.259970165037374e-07 6.8996397384642165 -0.5799238903797885 down TYHYHCGVQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYHYHCGVQDK 11 0 Q5JRC6;A0A0D9SGE8;Q8IWS0-5;Q8IWS0-3;Q8IWS0 Q5JRC6 PHF6 PHD finger protein 6 0 10668300.0 2467000.0 3606600.0 4594700.0 False True 3379116.5681682266 3447248.486568702 3509526.490816865 1.0 1.0201626422249792 1.0385929043931539 21.688214688815975 -6.972198338404662 0.19878865888665267 0.9888569271843719 1.0704068106789817 0.9999947004981437 3.5820026204587815e-05 0.07559584365676154 0.0064090855100518715 0.0006043803230803573 0.001962640867641659 1.0661091275348174e-07 6.972198338404662 0.08154988349460979 TYHYHCGVQDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYHYHCGVQDK 11 0 Q5JRC6;A0A0D9SGE8;Q8IWS0-5;Q8IWS0-3;Q8IWS0 Q5JRC6 PHF6 PHD finger protein 6 0 7107800.0 2897300.0 1787500.0 2423000.0 False True 3750611.964321233 1688024.053661215 1982038.8620794853 1.0 0.4500663011047332 0.5284574573254167 21.838694579828864 -10.675553083781471 6.715050290966989 1.003384705711864 0.4892618792152468 0.9826382878555963 0.03200305551457965 0.001627955484813549 7.865679556127646e-05 0.031106856060119356 0.010328941752976536 2.110799177217278e-11 10.675553083781471 -0.5141228264966171 TYHYHCGVQDK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYHYHCGVQDKAK 13 1 Q5JRC6;A0A0D9SGE8;Q8IWS0-5;Q8IWS0-3;Q8IWS0 Q5JRC6 PHF6 PHD finger protein 6 1 7462580.0 891900.0 847580.0 5723100.0 True False 1353077.5066240812 696322.7268272345 4591926.776476163 1.0 0.5146214636030384 3.393690866928228 20.367813051077324 -6.86352580916308 1.1677124529495984 0.7337333348374299 3.5428503146906847 0.9577883185796446 0.2585647831160541 0.14321828027022665 0.36908644365349985 0.1724317362190373 0.4042648706884535 1.3692230160697705e-07 6.86352580916308 2.809116979853255 up TYINPFVSFLDQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYINPFVSFLDQR 13 0 O95486;O95486-2 O95486 SEC24A Protein transport protein Sec24A 0 2113860.0 517610.0 792450.0 803800.0 False True 678591.7225423709 674219.5489459056 720630.4865940467 1.0 0.9935569894957093 1.0619500100799577 19.372184306607856 -6.883825849619069 1.0582601476075546 0.9957630504439852 1.0671665351565964 0.9766415309174707 0.004712587056927478 0.12429390562616045 0.25227978290283143 0.0034177542856197035 0.00835129482610838 1.306694762554902e-07 6.883825849619069 0.07140348471261126 TYINPFVSFLDQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYINPFVSFLDQR 13 0 O95486;O95486-2 O95486 SEC24A Protein transport protein Sec24A 0 2707260.0 517610.0 824050.0 1365600.0 False True 708984.404884295 787640.7462310579 1043073.4054148294 1.0 1.1109422729257346 1.4712219312991195 19.435394368130748 -6.949656368820523 0.5626018645347378 0.9953506295756367 1.6041090443519503 0.9991740514292083 0.005780973656024236 0.08362398759666784 0.03653544146849184 0.006177580112299736 0.0299662360548828 1.1229065915374548e-07 6.949656368820523 0.6087584147763136 TYIPPKGETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYIPPKGETK 10 1 Q5T7C4;P09429;B2RPK0 Q5T7C4 HMGB1;HMGB1P1 High mobility group protein B1;Putative high mobility group protein B1-like 1 0 2613580.0 859180.0 0.0 1754400.0 False True 1126393.3003109556 0.0 1572871.5173931243 1.0 0.0 1.396378615674394 20.10327922741335 -6.7144778486422725 1.7792463163139152 0.3880480331688142 1.393547893569134 0.48631035602424744 0.4211133654567483 0.3661598218181561 2.2622257272091173 0.1881570208567513 0.4754291591511326 1.9298437661057848e-07 6.7144778486422725 1.0054998604003198 TYIPPKGETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYIPPKGETK 10 1 Q5T7C4;P09429;B2RPK0 Q5T7C4 HMGB1;HMGB1P1 High mobility group protein B1;Putative high mobility group protein B1-like 1 0 2959400.0 1851600.0 1107800.0 0.0 False True 1792821.9715145973 1550150.3171006825 0.0 1.0 0.864642636988154 0.0 20.77380080400852 -7.159119740672165 0.9290962395271012 0.9933864959005607 1.4714955843486852e-17 0.989647625037567 0.045069765361980436 0.08866839621262473 0.14495004678207818 0.037756640089725374 0.06629668620596064 6.932346458010562e-08 7.159119740672165 -0.9933864959005607 down TYIPPKGETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYIPPKGETK 10 1 Q5T7C4;P09429;B2RPK0 Q5T7C4 HMGB1;HMGB1P1 High mobility group protein B1;Putative high mobility group protein B1-like 1 0 9033900.0 1777500.0 5442600.0 1813800.0 False True 2696597.4526564623 4471325.506772114 1455301.6349832176 1.0 1.6581360715769193 0.539680712651262 21.36270874184266 -6.747242729532749 1.6599866385513942 1.3882729863361878 0.5379114082316647 0.6370249889917601 0.2765246856862894 0.3048906049094273 1.6520891643218083 0.13164018076051692 0.32052530984273075 1.7896053543658912e-07 6.747242729532749 -0.8503615781045231 TYIPPKGETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYIPPKGETK 10 1 Q5T7C4;P09429;B2RPK0 Q5T7C4 HMGB1;HMGB1P1 High mobility group protein B1;Putative high mobility group protein B1-like 1 0 4758180.0 859180.0 2005200.0 1893800.0 False True 1176842.0644664671 1916603.633690333 1446523.4440352987 1.0 1.6285988507380929 1.2291568152699353 20.16648928893624 -10.122691145759546 4.255074771228166 0.9999353052318356 1.4288778325876164 0.6058471511607371 0.16307152850006235 37922299.171880245 4.790735729758144 29466.081010124286 0.05582372159516472 7.538915130156488e-11 10.122691145759546 0.42894252735578076 TYIPPKGETK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYIPPKGETK 10 1 Q5T7C4;P09429;B2RPK0 Q5T7C4 HMGB1;HMGB1P1 High mobility group protein B1;Putative high mobility group protein B1-like 1 0 5423600.0 1777500.0 1582900.0 2063200.0 False True 2301008.7897632243 1494810.2235190712 1687718.7702197223 1.0 0.6496325568894886 0.733469067014468 21.13383506393511 -10.722710420368719 5.646479491581143 1.008384432942374 0.6915508119521752 0.9475022550692992 0.03422611193697923 0.003667183197410199 0.00018008935010001986 0.03364070017753613 0.011046430128112605 1.893605819579405e-11 10.722710420368719 -0.31683362099019874 TYIQCIAAISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYIQCIAAISR 11 0 Q86VP6;Q86VP6-2;H0YH27;Q86VP6-3 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 18391600.0 5261900.0 6031700.0 7098000.0 False True 6898401.856312086 5131793.871382457 6363567.048823757 1.0 0.743910543090039 0.9224697518891348 22.717830742660755 -10.047177777012699 5.227938020275936 1.000001741510772 0.8331901477586209 0.5378153208325462 0.07289649174016179 1.4796983068800941e-06 2.69585060681134e-07 0.07058246187736585 0.023527241542021498 8.970615101642907e-11 10.047177777012699 -0.16681159375215115 TYIQCIAAISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYIQCIAAISR 11 0 Q86VP6;Q86VP6-2;H0YH27;Q86VP6-3 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 25627600.0 6042900.0 11770000.0 7814700.0 False True 9167521.095166115 9669551.540570263 6270121.119695308 1.0 1.0547618533071998 0.683949461867226 23.128100250016395 -6.869352463631174 1.1375815193768148 1.030850391704034 0.6625045602684895 0.9640292318279114 0.030996350134990382 0.13747378452054765 0.33291535908661196 0.02115529071947894 0.05002810658856323 1.3509756966759154e-07 6.869352463631174 -0.36834583143554445 TYIQCIAAISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYIQCIAAISR 11 0 Q86VP6;Q86VP6-2;H0YH27;Q86VP6-3 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 14980700.0 5261900.0 4418900.0 5299900.0 False True 7207366.627500761 4223658.386651808 4048172.774866762 1.0 0.5860196386480219 0.5616715485820254 22.781040804183647 -13.999999999999998 0.4032827237134044 8.127276403276369 0.560351820637161 0.9998423577199732 0.0025253811130148554 27.261811106999147 0.20969170427594036 170.22883987843363 0.0061743705580879545 1.0000000000000041e-14 13.999999999999998 -7.566924582639208 TYIQCIAAISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYIQCIAAISR 11 0 Q86VP6;Q86VP6-2;H0YH27;Q86VP6-3 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 17257000.0 6042900.0 6150100.0 5064000.0 False True 7822653.173367211 5807841.528627611 4142403.9610278616 1.0 0.7424388375546072 0.5295395141805566 22.899226572108844 -6.973309242805258 0.16052933243045667 1.2139159388068765 0.05241084646892175 0.9999980341976116 0.00026963064994463715 0.07524279074063409 0.004958028157206497 0.009804290621277712 0.02549837343045018 1.0633855565199458e-07 6.973309242805258 -1.1615050923379548 TYIQLLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYIQLLIR 8 0 P57740-2;P57740 P57740-2 NUP107 Nuclear pore complex protein Nup107 0 45356800.0 9236800.0 13602000.0 22518000.0 False True 14012900.900532903 11174616.82708892 18067307.430009976 1.0 0.7974520698040444 1.2893338473065834 23.740252312456306 -6.794889148474015 1.4767496430085332 0.887511711442514 1.29529280244126 0.8167797586434516 0.08639994712215122 0.228135949602514 0.9826716073805691 0.04603988881696736 0.10741933125519702 1.6036546634042497e-07 6.794889148474015 0.40778109099874604 TYIQLLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYIQLLIR 8 0 P57740-2;P57740 P57740-2 NUP107 Nuclear pore complex protein Nup107 0 5400500.0 1854300.0 1699700.0 1846500.0 False True 1541932.6094184055 1690543.378735965 2232594.6127486257 1.0 1.096379548891967 1.447919707457726 20.556308282578133 -6.946997111305037 0.5909006870730366 0.995947477179499 1.5660679189729394 0.9989439938703457 0.006255481125969368 0.08471461199353861 0.04113023163794774 0.006479283590368191 0.029458228065129894 1.1298034294968587e-07 6.946997111305037 0.5701204417934403 TYIQLLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYIQLLIR 8 0 P57740-2;P57740 P57740-2 NUP107 Nuclear pore complex protein Nup107 0 34103600.0 9236800.0 15019000.0 9847800.0 False True 11957219.684548507 14183179.447237939 8055601.446960935 1.0 1.186160313301418 0.6737018855119502 23.511378634548755 -6.808416810824786 1.4211227162680924 1.1016500417934771 0.6650540850184167 0.8556495323675282 0.08047085268513426 0.20897957598734146 0.8321149820843562 0.044527350335776074 0.10307940906005439 1.5544730218033364e-07 6.808416810824786 -0.43659595677506047 TYK(ub)NSEELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYKNSEELR 9 1 Q5QPM9;Q5QPM7;Q92530 Q5QPM9 PSMF1 Proteasome inhibitor PI31 subunit 1 7152900.0 1017300.0 1733200.0 4402400.0 True False 1333690.1515472133 1474613.3159606846 3946881.878802726 1.0 1.1056640961545576 2.9593694414133225 20.346992101852184 -6.91862682974416 0.8348453703708956 0.9570397910328559 3.2490566815388617 0.9937909413485053 0.07090087855635875 0.09898659333983087 0.10984983617254157 0.060648239644682175 0.17935324719301798 1.2060718200363363e-07 6.91862682974416 2.292016890506006 up TYK(ub)NSEELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYKNSEELR 9 1 Q5QPM9;Q5QPM7;Q92530 Q5QPM9 PSMF1 Proteasome inhibitor PI31 subunit 1 14964500.0 2188600.0 3254600.0 9521300.0 True False 2119124.0909790723 4554178.75251479 7027385.897122672 1.0 2.149085450871676 3.316174794594448 21.015036640374685 -6.970931608905254 0.23487321525461743 0.5533610793889228 4.945443549660267 0.9999887645730091 0.0031695247677762006 0.07600156080202153 0.007940424863848859 0.0289399682201408 0.11484622215571513 1.0692232433021724e-07 6.970931608905254 4.392082470271344 TYK(ub)NSEELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYKNSEELR 9 1 Q5QPM9;Q5QPM7;Q92530 Q5QPM9 PSMF1 Proteasome inhibitor PI31 subunit 1 31769100.0 2202100.0 14774000.0 14793000.0 True False 3340746.6950744325 12137464.270211134 11869157.065997768 1.0 3.6331591042525027 3.5528455609931604 21.67173916689858 -10.14815581646414 4.589896795558246 0.9996813211282909 3.5930023326663587 0.9992810136015192 0.03278786688382747 11466003.760537397 24.198355350168608 38668.42379175599 0.011224158918463517 7.10958389763611e-11 10.14815581646414 2.593321011538068 TYK(ub)NSEELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYKNSEELR 9 1 Q5QPM9;Q5QPM7;Q92530 Q5QPM9 PSMF1 Proteasome inhibitor PI31 subunit 1 9117800.0 1017300.0 1515200.0 6585300.0 True False 1393423.3014987973 1448253.453903647 5029987.76851075 1.0 1.0393492432241322 3.6098059814992203 20.410202163375075 -6.9102296605936395 0.8941699195431291 0.9209902216124042 3.943630678005445 0.9910079147380423 0.11579327175171206 0.10426638939889014 0.13794520731398055 0.09490922889023076 0.26241098130413887 1.229618360607712e-07 6.9102296605936395 3.0226404563930407 up TYK(ub)NSEELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYKNSEELR 9 1 Q5QPM9;Q5QPM7;Q92530 Q5QPM9 PSMF1 Proteasome inhibitor PI31 subunit 1 14362400.0 2188600.0 5092800.0 7081000.0 True False 1819917.8714194684 5065364.075558352 8561604.361155175 1.0 2.783292672216882 4.704390508829633 20.79544191580896 -6.970175962482825 0.2539463699241521 0.4191809596834887 7.125053340192956 0.9999837234124427 0.006102710492863486 0.0762456321587484 0.00882553472047055 0.04172710221774975 0.1829553431387643 1.0710852472109518e-07 6.970175962482825 6.705872380509467 TYK(ub)NSEELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYKNSEELR 9 1 Q5QPM9;Q5QPM7;Q92530 Q5QPM9 PSMF1 Proteasome inhibitor PI31 subunit 1 23987200.0 2202100.0 12723000.0 9062100.0 True False 2850661.859880508 12014953.865584146 7412890.78499814 1.0 4.214794477970032 2.6004104132185177 21.44286548899103 -9.173965067503241 11.588338060605487 1.0000000164890113 3.4076024455942817 0.7478235296414222 0.6590695345869325 0.0 1.3616752414349067e-17 0.6381413423710016 0.21271377762065152 6.699384937831659e-10 9.173965067503241 2.4076024291052702 TYLGEEGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYLGEEGKR 9 1 Q9BV86;Q9BV86-2;S4R338 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 1 6255870.0 1433910.0 1582160.0 3239800.0 True False 1879869.896004193 1346107.895211375 2904576.574356047 1.0 0.716064392579843 1.5450944666596056 20.84220138713949 -6.814247304637962 1.3964500883691449 0.846010538928969 1.5610726098518641 0.870657925503316 0.12371753628510132 0.201068783302244 0.7719197281984325 0.06964335257347674 0.160824003538312 1.533743359308027e-07 6.814247304637962 0.7150620709228951 TYLGEEGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYLGEEGKR 9 1 Q9BV86;Q9BV86-2;S4R338 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 1 6817800.0 1670280.0 813520.0 4334000.0 True False 1617257.8756650477 1138362.7784507556 3198795.3827869743 1.0 0.7038845168601444 1.9779130038068715 20.625118307678445 -6.8454958993059165 1.2565875356461946 0.8423958497962448 2.024598300010037 0.9335001339992878 0.1403823766443941 0.16247861088763255 0.4959656964196859 0.08751010532135191 0.20201007824496361 1.4272633066026783e-07 6.8454958993059165 1.1822024502137922 TYLGEEGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYLGEEGKR 9 1 Q9BV86;Q9BV86-2;S4R338 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 1 27748860.0 1852860.0 4310300.0 21585700.0 True False 2810924.0822104444 3541093.288472388 17319276.93365159 1.0 1.2597612688592272 6.161417536411057 21.4226130590803 -6.917864872558611 0.8404071510365123 0.883302977969789 6.914304897466289 0.993567036894189 0.19042921426189424 0.0994445017662422 0.1122432374555575 0.16224555109741814 0.4765131133166515 1.2081896957111354e-07 6.917864872558611 6.0310019194965 up TYLGEEGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYLGEEGKR 9 1 Q9BV86;Q9BV86-2;S4R338 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 1 6328880.0 1433910.0 1349870.0 3545100.0 True False 1964065.276960721 1290228.2799768457 2707820.3936263258 1.0 0.6569172089704678 1.3786814651173527 20.90541144866238 -6.777442486299165 1.545743560995027 0.8050902455428928 1.3839550811618653 0.7582481338396474 0.14493746847513253 0.2545790815840496 1.2012523788623748 0.07386378662970537 0.1746704710963839 1.6693888700585922e-07 6.777442486299165 0.5788648356189725 TYLGEEGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYLGEEGKR 9 1 Q9BV86;Q9BV86-2;S4R338 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 1 8948780.0 1670280.0 2664700.0 4613800.0 True False 1388911.8259501546 2650344.732198465 5578524.248199087 1.0 1.9082166935869844 4.016471127951422 20.40552358311272 -6.957031178846802 0.47543954446957126 0.9471591628371296 5.06475158459508 0.9996437181550886 0.023849770399948754 0.08077933245003838 0.025183921130944514 0.029456341067694774 0.1739473152767233 1.1039993587925452e-07 6.957031178846802 4.1175924217579505 TYLGEEGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYLGEEGKR 9 1 Q9BV86;Q9BV86-2;S4R338 Q9BV86 NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1;N-terminal Xaa-Pro-Lys N-methyltransferase 1, N-terminally processed 1 20593660.0 1852860.0 3932300.0 14808500.0 True False 2398563.795330913 3713464.048230489 12113504.948041283 1.0 1.548203160349199 5.050315931400969 21.19373938117275 -6.934522204814363 0.7086867047909406 0.9546200597642052 5.859751915688882 0.9973548271986571 0.0922747468494468 0.09035666166262811 0.06666836155516714 0.08645565727197314 0.30938103177210174 1.1627271010205866e-07 6.934522204814363 4.905131855924677 up TYLGNALVCTCYGGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYLGNALVCTCYGGSR 16 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 156863000.0 45122000.0 50284000.0 61457000.0 False True 59155378.96206955 42781823.20549684 55098019.177171245 1.0 0.7232110410944804 0.931411819920892 25.818006022110108 -9.802098684374563 5.801613296099506 1.0000000193866676 0.8273114309985792 0.4784273672952748 0.08499761203159968 2.133132770739033e-08 4.333289038586312e-09 0.08229859316294257 0.027432861321787943 1.5772528311256902e-10 9.802098684374563 -0.17268858838808843 TYLGNALVCTCYGGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYLGNALVCTCYGGSR 16 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 154340000.0 45122000.0 39799000.0 69419000.0 False True 61804822.77620045 38040548.582306765 53023661.929182746 1.0 0.6154948250568444 0.8579211062732937 25.881216083633 -10.370418615414142 6.195986861487903 1.000033079560665 0.736707965665069 0.6113081636682398 0.09897011487012734 4.523039085509877e-05 4.595874636746848e-06 0.09583942025643061 0.03194246722201983 4.2616853792552625e-11 10.370418615414142 -0.2633251138955959 TYNASITLQQQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYNASITLQQQLK 13 0 P11387 P11387 TOP1 DNA topoisomerase 1 0 25847800.0 6995800.0 10158000.0 8694000.0 False True 9171561.547423568 8642465.995573865 7794428.2787368 1.0 0.9423112902733195 0.8498474592831331 23.12873595689909 -6.964132183319333 0.37264695098207834 1.006900552134471 0.7820262439327603 0.9998941138401698 0.0006363659451880271 0.0782566934544776 0.015905953235436265 0.0012140605474607591 0.007841898567815937 1.086095005801429e-07 6.964132183319333 -0.22487430820171062 TYNASITLQQQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYNASITLQQQLK 13 0 P11387 P11387 TOP1 DNA topoisomerase 1 0 13961300.0 3847300.0 3822900.0 6291100.0 False True 3725169.5674055456 5349403.906160135 4643272.181045489 1.0 1.4360162160043128 1.2464592811218984 21.828874666976073 -10.164557710391938 4.429574767983646 0.9999334758994712 1.3412377485728035 0.8120616228270807 0.07738629465187473 5.1965509601105287e-05 9.801054015994133e-06 0.07494384916302275 0.02497631919522431 6.846085041542556e-11 10.164557710391938 0.3413042726733323 TYNASITLQQQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYNASITLQQQLK 13 0 P11387 P11387 TOP1 DNA topoisomerase 1 0 23487500.0 5192100.0 10262000.0 8033400.0 False True 7876795.293354499 8430665.922628034 6445594.968835698 1.0 1.0703167479470774 0.8183016986963877 22.909177351951886 -6.832233599876799 1.317798143690455 1.0375192342630077 0.8112005733238807 0.9102851246057697 0.03180390489248449 0.17807204836600724 0.6039802410354798 0.018944072750649594 0.043597439047272854 1.471520782637988e-07 6.832233599876799 -0.226318660939127 TYNASITLQQQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYNASITLQQQLK 13 0 P11387 P11387 TOP1 DNA topoisomerase 1 0 14103700.0 6995800.0 2857200.0 4250700.0 False True 9582336.314386401 2730959.456503102 3246772.2059144787 1.0 0.284999332824813 0.3388288721446721 23.19194601842198 -10.428382070606599 9.213008648798958 1.0000037266767992 0.3119141024847426 0.995430923455389 0.021975817403789785 1.6821772247007223e-06 1.043821928373606e-07 0.02127810866802571 0.007092664568681076 3.7292193533637304e-11 10.428382070606599 -0.6880896241920565 TYNASITLQQQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYNASITLQQQLK 13 0 P11387 P11387 TOP1 DNA topoisomerase 1 0 10253500.0 3847300.0 3956300.0 2449900.0 False True 3199200.4142886386 3934986.626635935 2962162.762942252 1.0 1.2299906592475554 0.9259072203517787 21.60927994241035 -6.704432849528055 1.8152307616579375 1.142190716822365 0.9267374029785396 0.43858629861359455 0.09700543011652417 0.3863580502752225 2.478025951605501 0.04258612713493354 0.10891809166226568 1.9750002296971428e-07 6.704432849528055 -0.2154533138438255 TYNASITLQQQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYNASITLQQQLK 13 0 P11387 P11387 TOP1 DNA topoisomerase 1 0 19275700.0 5192100.0 7782800.0 6300800.0 False True 6721275.801591921 7349680.338368955 5154119.051667524 1.0 1.093494829750655 0.7668364167479604 22.680303674044335 -6.830201499595283 1.3270872200348471 1.049949572981952 0.7580147698008265 0.9062639554604117 0.04205489687050776 0.1805619949033671 0.6218645464464363 0.024881484067400136 0.05725666864903732 1.478422285479917e-07 6.830201499595283 -0.2919348031811254 TYNFLPEFLVSTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYNFLPEFLVSTQK 14 0 P30740 P30740 SERPINB1 Leukocyte elastase inhibitor 0 24229300.0 4552600.0 8804700.0 10872000.0 False True 5968502.687441111 7491073.080451789 9747069.731588041 1.0 1.2551008976195088 1.6330845845303497 22.508937618680246 -6.96546063379164 0.3500609666916751 0.9634980350195215 1.937443071469286 0.999922323215075 0.0022921361796745215 0.07780504282029688 0.014311024671600165 0.005187607651891698 0.032487411296410786 1.0827778580435859e-07 6.96546063379164 0.9739450364497646 TYNFLPEFLVSTQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYNFLPEFLVSTQK 14 0 P30740 P30740 SERPINB1 Leukocyte elastase inhibitor 0 30491000.0 12043000.0 10329000.0 8119000.0 False True 11660701.557004921 14453423.56502341 5992390.335220927 1.0 1.2394986265934247 0.5138962099258192 23.475151253981867 -6.8177717511564735 1.3816031420095627 1.1293849025023743 0.4988146724240816 0.8791556815942994 0.10493972580578298 0.19639373710695662 0.7372352219211222 0.05969814121707887 0.13767536807448927 1.5213468823545508e-07 6.8177717511564735 -0.6305702300782927 TYNFLPEFLVSTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYNFLPEFLVSTQK 14 0 P30740 P30740 SERPINB1 Leukocyte elastase inhibitor 0 25243100.0 4552600.0 7218500.0 13472000.0 False True 6235819.249388993 6899562.801612633 10290191.064549334 1.0 1.1064404732848336 1.6501746848351326 22.572147680203138 -6.9393285925031405 0.6657850194252638 0.9938204313160851 1.793948899048521 0.9980745755348736 0.012494393592210462 0.08807433708168347 0.05601553250059535 0.012101330893382386 0.046938270911543366 1.149930008642784e-07 6.9393285925031405 0.800128467732436 TYNFLPEFLVSTQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYNFLPEFLVSTQK 14 0 P30740 P30740 SERPINB1 Leukocyte elastase inhibitor 0 26597600.0 12043000.0 6939100.0 7615500.0 False True 10014288.095359892 6901717.690996493 9207865.839906413 1.0 0.6891870520675749 0.9194728324395687 23.255556529416143 -9.802171567012257 6.1460708808486535 1.0000000085033072 0.8043299434233926 0.4904760697034892 0.09401377615567326 1.0932061780031072e-08 2.2069867152062434e-09 0.09102845141024098 0.030342815780317826 1.5769881611696114e-10 9.802171567012257 -0.19567006507991458 TYNFLPEFLVSTQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYNFLPEFLVSTQK 14 0 P30740 P30740 SERPINB1 Leukocyte elastase inhibitor 0 36277000.0 11211000.0 13715000.0 11351000.0 False True 14512860.501848403 12951748.193546066 9285234.471095432 1.0 0.8924324871651933 0.6397935451741464 23.790828568530234 -6.956785808796713 0.47858952090925605 1.0061452772792379 0.5155727011094615 0.9996317784996979 0.0028971025625414938 0.08086995918623263 0.025530563426658943 0.0035520067281936897 0.020841671810821572 1.1046232785697045e-07 6.956785808796713 -0.49057257616977634 TYNITK(ub)SVAVNPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYNITKSVAVNPK 13 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 199991400.0 22896400.0 46521000.0 130574000.0 True False 34735512.75105683 38218964.07976798 104765991.6673827 1.0 1.1002850124504113 3.016106093444531 25.04990805815827 -6.917740470082174 0.8413104507238385 0.95418887243926 3.309548818275078 0.9935299841867208 0.07461828205163426 0.09951969297364463 0.11263654894769776 0.06353357737169459 0.1863910530003806 1.208535827944542e-07 6.917740470082174 2.3553599458358176 up TYNITK(ub)SVAVNPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYNITKSVAVNPK 13 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 166448400.0 22896400.0 44683000.0 98869000.0 True False 29639841.155518852 42196351.7704862 80875856.4816082 1.0 1.42363623168842 2.7286197674696155 24.82103438025072 -6.950854702859136 0.5493845621683264 0.9818862678629072 3.2316107980825564 0.9992666329274028 0.01992184661480757 0.08314443288382042 0.034556574194111164 0.021639830322442315 0.1082468240161192 1.1198124641764563e-07 6.950854702859136 2.249724530219649 up TYNTDVPLVLMNSFNTDEDTKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYNTDVPLVLMNSFNTDEDTKK 22 1 A0A087WYS1;E7EUC7;Q16851-2;Q16851;C9JVG3;C9JQU9;C9JNZ1 A0A087WYS1 UGP2 UTP--glucose-1-phosphate uridylyltransferase 0 8054100.0 3719800.0 1965400.0 2368900.0 False True 3601716.9851155765 2750194.469425602 1748414.0245233213 1.0 0.7635787266992468 0.48543903692289025 21.78025339126474 -6.968980034965079 0.281482627391933 1.0601919506631983 0.18033307490743242 0.9999732974065534 0.0010866935071164989 0.07663506770986807 0.010209482340841573 0.0050940866542994 0.02548230564983681 1.0740387860493756e-07 6.968980034965079 -0.8798588757557658 down TYPGVMHSSCPQEMAAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYPGVMHSSCPQEMAAVK 18 0 O95372;Q5QPQ0 O95372 LYPLA2 Acyl-protein thioesterase 2 0 7193500.0 2246800.0 3063200.0 1883500.0 False True 2945576.5580421495 2606182.500260082 1688613.48780777 1.0 0.8847783953007644 0.5732709554594462 21.490118619684207 -6.953763539850265 0.5158765304164487 1.0054671015143928 0.43877831601126743 0.9994644841586774 0.004171200177763817 0.08200880995562766 0.029973713320211207 0.004757069730736152 0.025720926181548795 1.1123371962428596e-07 6.953763539850265 -0.5666887855031253 TYPGVMHSSCPQEMAAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYPGVMHSSCPQEMAAVK 18 0 O95372;Q5QPQ0 O95372 LYPLA2 Acyl-protein thioesterase 2 0 23485400.0 4311100.0 12553000.0 6621300.0 False True 6540253.883627163 10312819.072963333 5312597.152781111 1.0 1.5768224378537337 0.8122921903812692 22.640915209564444 -6.704875830393533 1.8133406022959582 1.3564590533266923 0.8143372098676284 0.440776659969208 0.24327409604439196 0.38548218243538834 2.467483152290603 0.10689089309234114 0.27326710072100363 1.9729867542648054e-07 6.704875830393533 -0.5421218434590639 TYPGVMHSSCPQEMAAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYPGVMHSSCPQEMAAVK 18 0 O95372;Q5QPQ0 O95372 LYPLA2 Acyl-protein thioesterase 2 0 8654700.0 2246800.0 2916600.0 3491300.0 False True 3077502.677486973 2787734.9680935657 2666726.8455805485 1.0 0.9058432307750173 0.8665229977177938 21.5533286812071 -13.999999999999963 0.11971254416691295 1.4488621276655793 0.8035217818000593 0.9996943433594118 0.0009790971121232275 11.96485368233486 0.10644596746413156 1.2781971968860046 0.05590544165115258 1.0000000000000858e-14 13.999999999999963 -0.64534034586552 TYQEFNHYLTSMVGCLWTSKPFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYQEFNHYLTSMVGCLWTSKPFGK 24 1 Q92674 Q92674 CENPI Centromere protein I 0 17661400.0 5914400.0 2825900.0 8921100.0 False True 8972577.200557755 2321596.066142524 7157840.674742963 1.0 0.2587435041515395 0.7977463458657136 23.09709100044802 -10.047562675138225 6.777078297713655 1.0000001655671733 0.5282449250106034 0.5052898700094732 0.22004698868497827 5.504386355532076e-07 7.753128482477573e-08 0.2130596552471933 0.07101986021333404 8.962668320127838e-11 10.047562675138225 -0.4717552405565699 TYQEFNHYLTSMVGCLWTSKPFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYQEFNHYLTSMVGCLWTSKPFGK 24 1 Q92674 Q92674 CENPI Centromere protein I 0 15455400.0 5914400.0 3972200.0 5568800.0 False True 7656307.390253522 3751143.5781555683 4555335.540713264 1.0 0.4899416111389119 0.5949781413573082 22.86821732254047 -9.943882535212046 6.079501484498966 1.0000001736846726 0.542459876248102 0.9619768363300882 0.042880983898200324 1.0091731296022532e-07 1.7605523704303004e-08 0.04151934959346239 0.013839778042184855 1.1379350245281243e-10 9.943882535212046 -0.45754029743657065 TYQELLVNQNPIAQPLASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYQELLVNQNPIAQPLASR 19 0 Q9NX24;J3QSY4;D6RC52;D6RCB9 Q9NX24 NHP2 H/ACA ribonucleoprotein complex subunit 2 0 9363300.0 2053300.0 3009600.0 4300400.0 False True 2691896.184185483 2560579.4113289183 3855435.8603496305 1.0 0.9512177424864924 1.4322379455046528 21.360191341289923 -6.88191790755008 1.0690824247335082 0.968928460547483 1.4676013714415528 0.9751982634840853 0.03404467123984838 0.12594305911488976 0.2621552238031765 0.024487544616525414 0.059514604903512236 1.312447960854353e-07 6.88191790755008 0.49867291089406973 TYQELLVNQNPIAQPLASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYQELLVNQNPIAQPLASR 19 0 Q9NX24;J3QSY4;D6RC52;D6RCB9 Q9NX24 NHP2 H/ACA ribonucleoprotein complex subunit 2 0 10952700.0 3263900.0 2006300.0 5682500.0 False True 3160289.281068535 2807426.052716283 4194082.7786541306 1.0 0.8883446428572057 1.3271198949344463 21.591625192682674 -6.839231576026982 1.2859872044772274 0.9405953372340384 1.3413310026458343 0.923121683064632 0.05162459141130312 0.16969712958038938 0.5454805923001493 0.031482357989283165 0.07251387102920115 1.447999540261365e-07 6.839231576026982 0.40073566541179584 TYQELLVNQNPIAQPLASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYQELLVNQNPIAQPLASR 19 0 Q9NX24;J3QSY4;D6RC52;D6RCB9 Q9NX24 NHP2 H/ACA ribonucleoprotein complex subunit 2 0 11190500.0 2053300.0 4233000.0 4904200.0 False True 2812460.4983460917 4045972.063340898 3745928.965169449 1.0 1.4385880497593444 1.3319045609253168 21.423401402812814 -10.071909851650354 4.984187033979857 0.9999908806962511 1.385246305344469 0.9456133485598254 0.04355335194462359 5947171.361993772 12017881.880447935 388.18617206459345 0.0149094728586072 8.474032949858583e-11 10.071909851650354 0.38525542464821794 TYQLVYFLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYQLVYFLDK 10 0 A6NKB8;Q9H4A4 A6NKB8 RNPEP Aminopeptidase B 0 13750700.0 4813300.0 5573300.0 3364100.0 False True 6310282.912063509 4741785.364553245 3016015.202725838 1.0 0.7514378405266533 0.47795245391613966 22.589273257048855 -6.969896575472219 0.260645605298128 1.07617855633543 0.14509100655811755 0.9999815638050319 0.000915432561975463 0.07633626792296315 0.009150202188301986 0.005685354480616388 0.025778863793202243 1.071774511277585e-07 6.969896575472219 -0.9310875497773125 down TYQLVYFLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYQLVYFLDK 10 0 A6NKB8;Q9H4A4 A6NKB8 RNPEP Aminopeptidase B 0 17222600.0 7164200.0 3968900.0 6089500.0 False True 6936776.39248481 5553702.467540071 4494477.268915847 1.0 0.8006171964194869 0.6479201598288638 22.725833949271223 -6.974091453166493 0.1267967001678959 1.248016604951925 0.19657815734240464 0.999999298585081 0.00012059376411775596 0.07499597437734865 0.003796472014467182 0.009954581489697715 0.021208479814049275 1.0614720102686874e-07 6.974091453166493 -1.0514384476095204 TYQLVYFLDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYQLVYFLDK 10 0 A6NKB8;Q9H4A4 A6NKB8 RNPEP Aminopeptidase B 0 16609000.0 5005900.0 7821700.0 3781400.0 False True 7594316.280311104 6425856.523778966 3034004.632553506 1.0 0.8461402299557279 0.3995099124880294 22.856488653418726 -6.95218840568425 0.5342787339305519 1.0068346086864672 0.21839124992606218 0.9993620196216546 0.006432679136977901 0.08261871676618056 0.032416329491970666 0.007132160479213721 0.03695540901315725 1.1163788351139743e-07 6.95218840568425 -0.788443358760405 down TYQLVYFLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYQLVYFLDK 10 0 A6NKB8;Q9H4A4 A6NKB8 RNPEP Aminopeptidase B 0 18217200.0 4813300.0 5192100.0 8211800.0 False True 6592907.084541597 4962695.8540213285 6272341.967329746 1.0 0.7527325640091868 0.9513772736213011 22.652483318571747 -9.948009232389918 5.749766340365369 1.0000001322511418 0.8520549190052924 0.4251489539720624 0.08109636310921672 1.3749478814728196e-07 2.50301135727768e-08 0.07852128614307588 0.02617373864661001 1.1271734940570649e-10 9.948009232389918 -0.14794521324584942 TYQLVYFLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYQLVYFLDK 10 0 A6NKB8;Q9H4A4 A6NKB8 RNPEP Aminopeptidase B 0 16732000.0 7164200.0 4333300.0 5234500.0 False True 5957349.727873226 4309955.652807293 6329009.748406557 1.0 0.7234686311333862 1.062386805796277 22.5062392247055 -6.689805167524522 1.867516340364559 0.8265986045739477 1.0612003854516001 0.3693879237541441 0.11695804349199418 0.4170545749291156 2.820026309807093 0.050108918808476316 0.13049952266807874 2.042654111274097e-07 6.689805167524522 0.23460178087765238 TYQLVYFLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYQLVYFLDK 10 0 A6NKB8;Q9H4A4 A6NKB8 RNPEP Aminopeptidase B 0 17261000.0 5005900.0 5657200.0 6597900.0 False True 6480236.231041195 5342371.846921526 5397149.900170956 1.0 0.8244100456293326 0.8328631407475376 22.627614975511175 -10.09970473367881 9.332520754473586 1.0000000000051197 0.8286365932827721 0.9981783457152668 0.0034509616311356496 4.929889788789808e-11 5.335153901336076e-12 0.003341379256342481 0.0011137930771490886 7.948684629151042e-11 10.09970473367881 -0.17136340672234762 TYQVAHMKSK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYQVAHMKSK 10 1 P33527-8;P33527-6;P33527-7;P33527-5;P33527-4;P33527-2;P33527-3;P33527;P33527-9;I3L4X2;A0A0A0MS99 P33527-8 ABCC1 Multidrug resistance-associated protein 1 1 9646390.0 735280.0 4817000.0 4094110.0 True False 963959.200461649 4098322.3765189364 3670490.7706762305 1.0 4.251551699030635 3.8077241950887535 19.878612560168726 -10.234920146469557 4.214307402034691 0.9982096403510267 4.029637946982467 0.9841593265879699 0.1811918204910667 15976249.929065855 892.374977889441 280232.9851453983 0.062026779460903646 5.82210258667369e-11 10.234920146469557 3.0314283066314403 TYQVAHMKSK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYQVAHMKSK 10 1 P33527-8;P33527-6;P33527-7;P33527-5;P33527-4;P33527-2;P33527-3;P33527;P33527-9;I3L4X2;A0A0A0MS99 P33527-8 ABCC1 Multidrug resistance-associated protein 1 1 6453280.0 735280.0 2321100.0 3396900.0 True False 1007132.886194865 2218546.1271487265 2594622.181351517 1.0 2.202833566016105 2.576246111031565 19.941822621691617 -10.135576879692708 0.2751763282519091 5.426353285961878e-25 2.7377441274469927 0.9990108524545294 0.021151881650859652 1.602038804841194 0.12699735432212936 1.3554644193459633 0.1484627352683793 7.318517578451435e-11 10.135576879692708 2.7377441274469927 TYSAK(ub)LDNAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYSAKLDNAR 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 43370100.0 16710000.0 19758600.0 6901500.0 True False 21906971.8198702 16810693.898419574 6187398.98386267 1.0 0.7673673037353265 0.282439719863543 24.38488673994151 -6.959227816213064 0.4461916987578059 1.0162611428455224 0.014443844468924997 0.9997404547559131 0.004815680730730923 0.07997824679457305 0.02216009064560317 0.006446003236870411 0.040135323504797725 1.0984294892779372e-07 6.959227816213064 -1.0018172983765974 down TYSAK(ub)LDNAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYSAKLDNAR 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 44859900.0 18543200.0 17064600.0 9252100.0 True False 17954556.26603451 23878583.77071341 6828697.452949555 1.0 1.3299456370239384 0.3803322873463449 24.097846662482716 -6.812876525508062 1.4025053668979013 1.1792184827472234 0.3626215839941417 0.8671673962847488 0.14346919976472872 0.20291526507019533 0.7861186521961615 0.08042372453098827 0.18579750124813252 1.538592016027898e-07 6.812876525508062 -0.8165968987530817 down TYSAK(ub)LDNAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYSAKLDNAR 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 93746700.0 39159000.0 34907700.0 19680000.0 True False 59407065.906371005 28678148.199895017 15790239.37394959 1.0 0.48273968361092684 0.26579732786056 25.824131200318725 -11.749184966010215 0.15119346714562884 2.297241710320533 2.94113805597967e-14 0.9996085758799873 0.006093247563261464 4.790590689327454 0.09878363749682842 2.206575156677679 0.20422300017159528 1.7816198140011443e-12 11.749184966010215 -2.297241710320504 TYSAK(ub)LDNAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYSAKLDNAR 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 37622900.0 16710000.0 12673800.0 8239100.0 True False 22888138.57077059 12113829.609347973 6293194.269590888 1.0 0.5292623326222778 0.27495439395965743 24.448096801464402 -9.219854567455586 0.19177728641473632 1.4549679847960029 7.072792328421448e-10 0.9995959568210684 0.006037527400634462 0.6525224429547719 0.06860716288487291 0.32410646421283074 0.1466603661672668 6.027613994791217e-10 9.219854567455586 -1.4549679840887237 TYSAK(ub)LDNAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYSAKLDNAR 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 55998400.0 18543200.0 29550700.0 7904500.0 True False 15419492.403045544 29391504.513745267 9557294.403721383 1.0 1.9061265925939348 0.6198190027211075 23.878251937916993 -6.7174488564426875 1.768840121537741 1.552790384071054 0.6221546003826102 0.5002740290652852 0.38142672162224367 0.3603086110126982 2.2018352794610854 0.17132451298964835 0.43132841200421934 1.9166867630648385e-07 6.7174488564426875 -0.9306357836884438 TYSAK(ub)LDNAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYSAKLDNAR 10 1 P02545;P02545-3;P02545-6;P02545-5;P02545-4;P02545-2;Q3BDU5;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 79118400.0 39159000.0 28694900.0 11264500.0 True False 50692097.43929009 27098003.59015564 9214476.583530482 1.0 0.5345607098346793 0.18177343311876037 25.595257522411174 -8.042777646888984 0.3241780102385616 1.1086988412757264 7.400047493787238e-25 0.9988415267074898 0.011405350152719271 0.0952393167298617 0.0666755792362639 0.05897603608850317 0.08877309082033505 9.06196442908423e-09 8.042777646888984 -1.1086988412757264 down TYSVSFPMFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYSVSFPMFSK 11 0 Q96SL4 Q96SL4 GPX7 Glutathione peroxidase 7 0 17121700.0 4861500.0 5486800.0 6773400.0 False True 6373473.578832972 4668190.827378889 6072553.543040695 1.0 0.7324406023871315 0.9527855521686531 22.603648433031957 -10.008815359603139 6.173156917725647 1.0000001197375248 0.8426130775822617 0.40485117336274223 0.08995544906067747 1.482168017313461e-07 2.3757733904882738e-08 0.08709905521960848 0.029032996342714053 9.799065043320336e-11 10.008815359603139 -0.1573870421552631 TYSVSFPMFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYSVSFPMFSK 11 0 Q96SL4 Q96SL4 GPX7 Glutathione peroxidase 7 0 18292300.0 7765800.0 3598300.0 6928200.0 False True 7519278.929783995 5035119.954886609 5113496.578455182 1.0 0.6696280324091198 0.680051455226715 22.842162888899583 -9.974694237947801 5.084485850179909 1.0000019470020223 0.6748397438151584 0.9992298890876553 0.004255344558237214 9.600970113831767e-08 1.9368817938222474e-08 0.004120244847233802 0.0013734065487890233 1.0599997480849573e-10 9.974694237947801 -0.32516220318686384 TYSVSFPMFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYSVSFPMFSK 11 0 Q96SL4 Q96SL4 GPX7 Glutathione peroxidase 7 0 17772000.0 4861500.0 5572700.0 7337800.0 False True 6658927.927097619 5326479.687545435 5604762.7667347165 1.0 0.7999004863635836 0.8416914596607785 22.666858494554848 -10.56553443509195 6.355510960004819 1.0003105253823326 0.8207959730121812 0.9608106063520483 0.017061093405400785 7.519677360902103e-05 5.140498168827061e-06 0.01654761676302114 0.00550644421893387 2.7193528607981252e-11 10.56553443509195 -0.17951455237015135 TYSVSFPMFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYSVSFPMFSK 11 0 Q96SL4 Q96SL4 GPX7 Glutathione peroxidase 7 0 15506900.0 7765800.0 3671900.0 4069200.0 False True 6457606.783272085 3652118.7458849163 4920050.906144985 1.0 0.5655529778222853 0.7619000461424787 22.62256816433386 -10.20798068806217 5.842195542866032 1.0000079352544091 0.6637265119823772 0.7963707539749711 0.0801583549793276 8.285049991486329e-06 1.1232806329300813e-06 0.07761482338102665 0.025870997824523984 6.194686206109905e-11 10.20798068806217 -0.3362814232720319 TYSYLTPDLWK(ub)ETVFTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYSYLTPDLWKETVFTK 17 1 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 6280800.0 1884800.0 4396000.0 0.0 True False 2470991.052429164 3740133.935473791 0.0 1.0 1.5136169480650152 0.0 21.236658355936058 -6.8352274777380035 1.4405752278617334 1.2768551695862016 5.999364066505262e-21 0.8721557960055437 0.2247135251169275 0.18922918206008538 0.7880598134320767 0.12495760438754808 0.26896286783321605 1.4614115058236244e-07 6.8352274777380035 -1.2768551695862016 down TYSYLTPDLWK(ub)ETVFTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYSYLTPDLWKETVFTK 17 1 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 15897900.0 4939900.0 4857900.0 6100100.0 True False 4783085.578464553 6797684.803613831 4502300.810922669 1.0 1.421192385563797 0.9412963111498374 22.189510173427383 -6.674879295172554 1.9201136697537655 1.2677067473397616 0.9431892293671275 0.3008654309908676 0.17871415792032497 0.4499825501020282 3.2029014989282913 0.0748088243187292 0.198604752737586 2.1140765301118136e-07 6.674879295172554 -0.3245175179726342 TYSYLTPDLWK(ub)ETVFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYSYLTPDLWKETVFTK 17 1 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 62342700.0 8978700.0 7357700.0 46006300.0 True False 13621344.330895405 6044660.949027513 36913134.639722355 1.0 0.44376390480910516 2.709947986264279 23.699365758443125 -6.841785773606735 1.2739347729779076 0.7041082109071284 2.787220676256496 0.9274940086826216 0.259657078995014 0.16673141527828503 0.5248279151129865 0.1597660831134427 0.3682945535156774 1.4395084759774707e-07 6.841785773606735 2.083112465349368 up TYSYLTPDLWK(ub)ETVFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYSYLTPDLWKETVFTK 17 1 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 9716000.0 1884800.0 3863400.0 3967800.0 True False 2581661.4948048107 3692702.2134446627 3030687.359406094 1.0 1.4303587905988633 1.1739290241981288 21.29986841745895 -10.279002762150467 4.871072777412053 0.9999070727025486 1.3021439073985863 0.6492580046715735 0.10468701375812509 0.00010569055610466286 1.5643842175052727e-05 0.1013938303246876 0.03378758840397786 5.2601392088603516e-11 10.279002762150467 0.3022368346960377 TYSYLTPDLWK(ub)ETVFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYSYLTPDLWKETVFTK 17 1 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 13153000.0 4939900.0 5213600.0 2999500.0 True False 4107745.7246756065 5185513.301981422 3626681.58187897 1.0 1.2623744626722064 0.8828885293685926 21.96991544886166 -6.720726675201841 1.7568962286448015 1.159503545983607 0.883463888670496 0.5158549985516852 0.11039843297878545 0.35390836872054054 2.1353430920240983 0.049888164679589814 0.12512178319310144 1.9022751069678558e-07 6.720726675201841 -0.276039657313111 TYSYLTPDLWK(ub)ETVFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYSYLTPDLWKETVFTK 17 1 P15880;H0YEN5;E9PQD7 P15880 RPS2 40S ribosomal protein S2 1 68954500.0 8978700.0 6336200.0 53639600.0 True False 11623104.146636885 5983584.90003256 43877743.18877371 1.0 0.5148009365264008 3.775045171686741 23.470492080535575 -6.869036642033702 1.139247262410628 0.7271505763581159 3.962462729415392 0.9637087168974384 0.2736106965272846 0.13777832186037098 0.33482524623648346 0.18650350770923757 0.4408097241123031 1.3519584917506868e-07 6.869036642033702 3.235312153057276 up TYTAYVDLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYTAYVDLEK 10 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 21022900.0 5798200.0 6295000.0 8929700.0 False True 7601496.349848677 5355810.537717811 8005740.303730858 1.0 0.7045731907540058 1.0531795235145023 22.857852009461354 -6.6821073659903645 1.894150847987483 0.8134384404475533 1.0518835686396424 0.33391308707498957 0.12515098888561613 0.4338545058947632 3.0112273304102164 0.05297898041850847 0.13936513549495338 2.0791826094319648e-07 6.6821073659903645 0.23844512819208907 TYTAYVDLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYTAYVDLEK 10 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 24127600.0 9178200.0 6071100.0 8878300.0 False True 8886843.064892687 8495321.890368246 6552806.88670919 1.0 0.9559437280859455 0.7373604821036995 23.083239580787502 -6.939978152754806 0.6597678089420536 1.0024544406064626 0.6784536180186742 0.9981610177044291 0.004924826636586706 0.08777665378802717 0.054655307410719715 0.004793148435138481 0.018814842523483744 1.1482113809796112e-07 6.939978152754806 -0.3240008225877884 TYTAYVDLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYTAYVDLEK 10 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 21857400.0 5798200.0 5976200.0 10083000.0 False True 7941951.2304633185 5712151.723349381 7701603.065903431 1.0 0.7192378242564637 0.9697368873737259 22.921062070984245 -10.286286296099483 7.428070959728269 1.0000007766934595 0.8444873560471796 0.3394437109362678 0.10226581428042161 1.315451919287823e-06 1.2623508731537518e-07 0.09901894391004638 0.033006149632867805 5.172657270336098e-11 10.286286296099483 -0.15551342064627993 TYTAYVDLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYTAYVDLEK 10 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 18401700.0 9178200.0 5833500.0 3390000.0 False True 7632079.963201215 5802073.7776409155 4098833.3264109646 1.0 0.7602218275510942 0.5370532471061457 22.86364485622178 -6.9719889046620755 0.2051948658234808 1.1242485297917522 0.16682978448268831 0.9999940206325098 0.00046221316940144936 0.07566244743656125 0.006668398567993909 0.00694505911979525 0.02338981031551645 1.0666233709330719e-07 6.9719889046620755 -0.9574187453090639 TYTIANQFPLNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYTIANQFPLNK 12 0 Q9NSD9;Q9NSD9-2 Q9NSD9 FARSB Phenylalanine--tRNA ligase beta subunit 0 30329200.0 12596000.0 8303100.0 9430100.0 False True 16305770.304279963 7841025.185988512 7713918.560997005 1.0 0.4808742573744209 0.47307906446911274 23.958879261563744 TYTMDK(ub)QPLNTGEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYTMDKQPLNTGEQK 15 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2;A0A0C4DG73 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34;Ubiquitin carboxyl-terminal hydrolase 1 25831200.0 7244600.0 12068000.0 6518600.0 True False 9497740.756806197 10267501.440695565 5844117.802826516 1.0 1.0810467145397444 0.6153166266028635 23.179152947338242 -6.8620044866134355 1.1754769311888562 1.0442329239034287 0.591875228072008 0.9560360247509492 0.042597093004955844 0.1447561893110601 0.3789230131672382 0.028238827259449522 0.06607775157758623 1.3740277801203408e-07 6.8620044866134355 -0.4523576958314207 TYTMDK(ub)QPLNTGEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYTMDKQPLNTGEQK 15 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2;A0A0C4DG73 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34;Ubiquitin carboxyl-terminal hydrolase 1 35971900.0 16984000.0 13104000.0 5883900.0 True False 25765969.69671866 10765488.817980703 4720944.585995013 1.0 0.4178181122114611 0.18322402151222872 24.61896355324126 -10.351647890378102 0.20632552250503802 1.7342205350037392 7.018941350303276e-10 0.9993562656172901 0.008711817234013746 1.9970739337378423 0.1020570994521641 0.9069974040236196 0.1354386042510545 4.449919039432198e-11 10.351647890378102 -1.734220534301845 TYTMDK(ub)QPLNTGEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYTMDKQPLNTGEQK 15 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2;A0A0C4DG73 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34;Ubiquitin carboxyl-terminal hydrolase 1 21267900.0 7323400.0 9958800.0 3985700.0 True False 6089731.581629052 9905149.96773298 4819091.442205368 1.0 1.6265330967318716 0.7913471025132149 22.537947208886507 -6.70595336988791 1.8096141838007958 1.3867613023123238 0.7935327720119546 0.4458682745973469 0.26419106222379624 0.3832704246767858 2.443980045701959 0.11629258452551892 0.29689832750405754 1.9680975926097016e-07 6.70595336988791 -0.5932285303003692 TYTMDK(ub)QPLNTGEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 TYTMDKQPLNTGEQK 15 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2;A0A0C4DG73 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34;Ubiquitin carboxyl-terminal hydrolase 1 44850300.0 23124500.0 16257100.0 5468700.0 True False 29935121.102042012 15352378.093860574 4473452.713600529 1.0 0.5128550521485385 0.1494382701293089 24.83533577086321 -8.09466432055296 0.3509157162727488 1.0941158111663227 9.014872166863757e-16 0.9983409318270557 0.014193469313734716 0.09330031460127211 0.07778548332504542 0.0599311226507935 0.0869538967835485 8.041474321093519e-09 8.09466432055296 -1.0941158111663218 down TYTWNTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYTWNTK 7 0 O75400-2;O75400;O75400-3;F5H578 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 0 3530400.0 1022900.0 1282400.0 1225100.0 False True 1341031.8057776904 1091070.9187560494 1098338.4039890098 1.0 0.8136055491415554 0.8190248726815708 20.354912023936876 -10.224330786905993 5.317410356529175 1.0000137886480642 0.8163152109115313 0.9993475840659837 0.002212429570793355 3.616785922519959e-07 5.276309467734331e-08 0.0021423364543023066 0.0007140585735121921 5.96580718839205e-11 10.224330786905993 -0.18369857773653298 TYTWNTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYTWNTK 7 0 O75400-2;O75400;O75400-3;F5H578 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 0 3895100.0 1366100.0 1194900.0 1334100.0 False True 1322733.9032653333 1672029.8013211836 984659.1878578934 1.0 1.2640711765182475 0.7444121492819831 20.335091430599512 -6.768536169240878 1.57987619822248 1.151743078934625 0.7416360328739305 0.7250257261342647 0.11125208816832277 0.2687871051466863 1.3237826722625934 0.055510992158667845 0.13232716485823443 1.703977401473732e-07 6.768536169240878 -0.4101070460606945 TYTWNTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYTWNTK 7 0 O75400-2;O75400;O75400-3;F5H578 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 0 14862100.0 4402900.0 7024600.0 3434600.0 False True 6679521.195106126 5771005.246549698 2755749.8045613426 1.0 0.8639848692714577 0.41256696761144995 22.671313259717603 -6.9491602639540195 0.5679862085358651 1.005675338894998 0.24900459843372544 0.9991337383338332 0.0073897698463651846 0.08382467033863084 0.03737121110742942 0.007847111198733941 0.03759362740016564 1.1241900472377076e-07 6.9491602639540195 -0.7566707404612725 down TYTWNTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYTWNTK 7 0 O75400-2;O75400;O75400-3;F5H578 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 0 3913400.0 1022900.0 1005400.0 1885100.0 False True 1401093.7728331068 960978.1035868035 1439878.204853175 1.0 0.6858770784796513 1.0276815390747498 20.418122085459768 -6.665052954343793 1.954867161696059 0.7986530236051547 1.0262763660013052 0.25737714820468194 0.13358595686178337 0.4725538942266003 3.4765764316770236 0.0551075776461345 0.1481923116523368 2.1624548354621618e-07 6.665052954343793 0.22762334239615056 TYYMSGGLQPVPIVFR ddPTM_RPMI8226_Bortezomib_1h_R1 2 TYYMSGGLQPVPIVFR 16 0 P11177-2;P11177;C9J634;F8WF02 P11177-2 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 64845140.0 18952070.0 31291600.0 14601470.0 False True 24846347.302106936 26623015.253701493 13090649.95159041 1.0 1.0715062029034705 0.5268641620605674 24.566530438877468 -6.873851245927756 1.1134708241687952 1.0415586261645773 0.49253559861885776 0.9683804326661799 0.042972112032477444 0.13321837283869778 0.30635985334852217 0.029874606485083742 0.07124490598341066 1.3370534041980206e-07 6.873851245927756 -0.5490230275457195 TYYMSGGLQPVPIVFR ddPTM_RPMI8226_Bortezomib_2h_R1 2 TYYMSGGLQPVPIVFR 16 0 P11177-2;P11177;C9J634;F8WF02 P11177-2 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 107996700.0 46957000.0 24411300.0 36628400.0 False True 45466375.73796231 34158859.39324776 27034323.2115539 1.0 0.7512993687932487 0.5946003562580313 25.438296671301224 -9.498579061176008 0.08237009196099822 1.7520182623957914 2.1724913746468276e-07 0.9999751553134639 0.0008319749395267807 0.9709594201750755 0.03253536806206109 0.4210592905595817 0.2655350125658227 3.172641047551477e-10 9.498579061176008 -1.7520180451466538 TYYMSGGLQPVPIVFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYYMSGGLQPVPIVFR 16 0 P11177-2;P11177;C9J634;F8WF02 P11177-2 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 23536900.0 8876000.0 7056800.0 7604100.0 False True 13465540.92251971 5797458.90496994 6101146.302004567 1.0 0.4305403650940079 0.45309329473731264 23.682768849532895 -10.080016534281064 5.0592245879841045 1.000012370115857 0.4418168299137343 0.9987771238472314 0.009207194978661255 5148285.829435139 10257462.92298679 473.1020617600229 0.0031518672453671043 8.317321051369382e-11 10.080016534281064 -0.5581955402021227 TYYMSGGLQPVPIVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 TYYMSGGLQPVPIVFR 16 0 P11177-2;P11177;C9J634;F8WF02 P11177-2 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 92905870.0 18952070.0 36512200.0 37441600.0 False True 25959162.439434092 34898970.274300925 28598665.213957172 1.0 1.3443796715600707 1.1016790422526674 24.62974050040036 -10.634466626353852 5.8463251123199855 0.9983732041799547 1.223029356905713 0.5296231350469608 0.09908211700925118 0.002115259288533109 0.00013225360003412437 0.09658939290181213 0.03197861575698368 2.3202424792839526e-11 10.634466626353852 0.22465615272575823 TYYMSGGLQPVPIVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 TYYMSGGLQPVPIVFR 16 0 P11177-2;P11177;C9J634;F8WF02 P11177-2 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 95726200.0 46957000.0 29270700.0 19498500.0 False True 39046826.04781321 29113012.929320958 23575546.199122168 1.0 0.7455923022698899 0.6037762498353564 25.2187019467355 -13.99999999999634 0.06915483809746807 2.482779307049736 0.08002014656645419 0.9999272532225852 0.0013980912260365085 12.36899167263056 0.07068629903403445 2.9744662428965527 0.48307641758821923 1.0000000000084258e-14 13.99999999999634 -2.402759160483282 TYYMSGGLQPVPIVFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYYMSGGLQPVPIVFR 16 0 P11177-2;P11177;C9J634;F8WF02 P11177-2 PDHB Pyruvate dehydrogenase E1 component subunit beta, mitochondrial 0 28096700.0 8876000.0 10556000.0 8664700.0 False True 11490156.972117241 9968549.320530232 7087813.507329797 1.0 0.8675729448014121 0.6168595889968731 23.453895171625344 -6.96110374094411 0.41959055166947135 1.0111309475296728 0.46385042531675563 0.9998089639248322 0.002195989199457482 0.07930919853437485 0.019691902994102013 0.0032423561249738195 0.020872339247938618 1.0936950815505988e-07 6.96110374094411 -0.5472805222129171 TYYYNNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYYYNNR 7 0 O14776;O14776-2;G3V220 O14776 TCERG1 Transcription elongation regulator 1 0 4437700.0 1528200.0 1594400.0 1315100.0 False True 2003484.9991098496 1356521.7349225227 1179026.0673299693 1.0 0.6770810540259731 0.5884875942938489 20.934080277100946 -13.999999999999998 0.18148148342101333 2.6831731065261124 0.519179177415837 0.9994964256663871 0.003968482970223538 12.224240924545672 0.13505919472455385 7.257849110599656 0.06532342111472852 1.0000000000000041e-14 13.999999999999998 -2.1639939291102754 TYYYNNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYYYNNR 7 0 O14776;O14776-2;G3V220 O14776 TCERG1 Transcription elongation regulator 1 0 3823200.0 1515000.0 1152300.0 1155900.0 False True 1466907.154269073 1612419.3991651179 853135.113743302 1.0 1.0991966290931006 0.5815876698538567 20.484346129964305 -6.85705700807298 1.2005024334227627 1.0534538533421214 0.5578935694944807 0.9499643380944359 0.05017474200406315 0.14986334795467443 0.41209516828020015 0.032634493352024514 0.07594446931895786 1.3897701897504557e-07 6.85705700807298 -0.4955602838476407 TYYYNNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYYYNNR 7 0 O14776;O14776-2;G3V220 O14776 TCERG1 Transcription elongation regulator 1 0 13477600.0 4384100.0 5493700.0 3599800.0 False True 6651000.220642035 4513306.312525982 2888297.9521516114 1.0 0.6785906123590991 0.4342652016741022 22.665139888110897 -7.587596840242313 0.17286694440130254 1.256887514336242 1.610852540249968e-14 0.9999649945857262 0.0013706945562775292 0.13381997521701872 0.01807348751503484 0.043126158124103725 0.07482451212058755 2.5846584406706833e-08 7.587596840242313 -1.2568875143362257 down TYYYNNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYYYNNR 7 0 O14776;O14776-2;G3V220 O14776 TCERG1 Transcription elongation regulator 1 0 4246800.0 1528200.0 1580000.0 1138600.0 False True 2093216.838052158 1510190.3756387008 869686.1302030795 1.0 0.7214686735675258 0.41547827936085474 20.997290338623838 -6.969916971313064 0.26016186432117067 1.0857374536599784 0.04212931062084617 0.9999817273122147 0.001020420023244688 0.07632966337301766 0.009126511407973525 0.006380951826564119 0.02886366949155206 1.0717241785426046e-07 6.969916971313064 -1.0436081430391322 down TYYYNNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYYYNNR 7 0 O14776;O14776-2;G3V220 O14776 TCERG1 Transcription elongation regulator 1 0 4904210.0 1515000.0 2445000.0 944210.0 False True 1259789.6258797832 2431828.2997054993 1141639.9454662225 1.0 1.930344757369481 0.906214753649007 20.26475140539858 -6.667575961239045 1.946150298221618 1.5950687622031257 0.9104097566483449 0.26831738979826536 0.3954121412927631 0.4666804406087254 3.405361441742347 0.16371236462171415 0.43875621330622355 2.1499286084235168e-07 6.667575961239045 -0.6846590055547808 TYYYNNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYYYNNR 7 0 O14776;O14776-2;G3V220 O14776 TCERG1 Transcription elongation regulator 1 0 13205600.0 4384100.0 3063000.0 5758500.0 False True 5675303.873530784 2892541.357406602 4710512.087199631 1.0 0.5096716267294885 0.8300017394961222 22.436266210203346 -10.149923152125004 5.343950940363311 1.0000094614968327 0.6698366831126824 0.5861695664115805 0.13077422092151178 1.4742044918038062e-05 2.3452502215978396e-06 0.12662522158436312 0.04220719831179224 7.080710656047513e-11 10.149923152125004 -0.33017277838415027 TYYYNTETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 TYYYNTETK 9 0 O75400-2;O75400;O75400-3;F5H578;H0YG38 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 0 7764300.0 1772200.0 3307400.0 2684700.0 False True 2323371.36200921 2813948.812144223 2406912.9974608547 1.0 1.211148961443155 1.03595707376689 21.14778833875687 -9.964992911296225 9.663643256808108 1.0000068531023947 1.1235530176051887 0.3987344619456745 0.0715217887564149 1.0355405873690615e-10 0.0 0.06925067413668856 0.023083558045562846 1.0839446063931665e-10 9.964992911296225 0.12354616450279399 TYYYNTETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 TYYYNTETK 9 0 O75400-2;O75400;O75400-3;F5H578;H0YG38 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 0 10694600.0 3706200.0 2171700.0 4816700.0 False True 3588548.7096713088 3038871.135265888 3555061.7720973776 1.0 0.8468245469473458 0.9906683898469366 21.774969072791194 -10.50485923382162 7.109228004475723 1.0000245342985101 0.9187464683994723 0.2984633625655585 0.05872400295751044 2.284257058707953e-05 1.5908646213086183e-06 0.05687643075522613 0.01895309045642275 3.127092775276963e-11 10.50485923382162 -0.08127806589903785 TYYYNTETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 TYYYNTETK 9 0 O75400-2;O75400;O75400-3;F5H578;H0YG38 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 0 34036000.0 9862200.0 16082000.0 8091800.0 False True 14961678.423397247 13212041.45076048 6492452.183238072 1.0 0.8830587770219239 0.4339387600448022 23.834768692196814 -6.945810270494579 0.6030952159052019 1.005026249118101 0.2888583322095867 0.9988300745964124 0.008345702086753727 0.08521314312202563 0.04327120767553019 0.008539613450379345 0.03778140167034907 1.1328951811694071e-07 6.945810270494579 -0.7161679169085143 down TYYYNTETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 TYYYNTETK 9 0 O75400-2;O75400;O75400-3;F5H578;H0YG38 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 0 10636600.0 1772200.0 4901600.0 3962800.0 False True 2427430.231904223 4685031.104576367 3026868.2564278604 1.0 1.930037388098749 1.2469434617090527 21.210998400279763 -10.174864203890898 4.590652290946514 0.9999148619286613 1.5884904249079792 0.4973846844051474 0.2788719277689916 195557828.38167012 36.370548784511136 198237.68501052243 0.09546527841898521 6.685529294213751e-11 10.174864203890898 0.5885755629793179 TYYYNTETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 TYYYNTETK 9 0 O75400-2;O75400;O75400-3;F5H578;H0YG38 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 0 11067400.0 3706200.0 5490100.0 1871100.0 False True 3081869.512498777 5460523.741600473 2262338.3590110806 1.0 1.7718218501642808 0.7340798660799817 21.55537434822547 -6.707525602800398 1.803804574379595 1.4756821177937265 0.7366660753567664 0.453469204646337 0.32536885556002604 0.380057415242415 2.4089144001636873 0.14362197476861838 0.3659964760185041 1.9609855668186043e-07 6.707525602800398 -0.7390160424369601 TYYYNTETK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 TYYYNTETK 9 0 O75400-2;O75400;O75400-3;F5H578;H0YG38 O75400-2 PRPF40A Pre-mRNA-processing factor 40 homolog A 0 26407000.0 9862200.0 7475300.0 9069500.0 False True 12766812.313025545 7059292.983683185 7418944.06092855 1.0 0.5529409229648365 0.5811117042395346 23.605895014289263 -10.731533458540033 6.8427429638737225 1.0063010648506638 0.5670263136022663 0.9968351037849572 0.011500673296426895 0.0011106643914897268 4.357548235448962e-05 0.011187226611369342 0.003711826345602813 1.855523852262303e-11 10.731533458540033 -0.43927475124839754 VAACELLHSMVMFMLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAACELLHSMVMFMLGK 17 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 994670000.0 345240000.0 370550000.0 278880000.0 False True 523754320.4248207 304422457.3796359 223759245.7625537 1.0 0.5812314008841335 0.42722176607738727 28.96431499868369 -13.999999999999998 0.1390325607903889 2.998741590781272 0.23438692420370727 0.999606818650199 0.004798953341500232 11.933171472597538 0.11675248472772509 6.474456795386688 0.1722827355051599 1.0000000000000041e-14 13.999999999999998 -2.7643546665775647 VAACELLHSMVMFMLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAACELLHSMVMFMLGK 17 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 726270000.0 345240000.0 141040000.0 239990000.0 False True 446919985.6978098 133191000.01587592 196314282.5053467 1.0 0.2980197893990236 0.4392604689602915 28.73544132077614 -9.943777998961494 6.9547821949294235 1.000000028476263 0.368640129190007 0.9638236703005844 0.0576612659748497 2.5475683130206964e-08 3.827863204080434e-09 0.05583028320625004 0.018610093570151275 1.13820896256659e-10 9.943777998961494 -0.6313598992862559 VAAGLQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAAGLQIK 8 0 Q14974;J3QR48 Q14974 KPNB1 Importin subunit beta-1 0 43852000.0 13038000.0 10588000.0 20226000.0 False True 17092944.2601716 9008311.67170074 18133207.541491907 1.0 0.5270193089373769 1.060859221529449 24.026897586895398 -6.672879235760762 1.9269484066813984 0.6988513173805884 1.0587408277626449 0.29193835389139755 0.20077918392362762 0.4545512855511376 3.2565609724316786 0.08379726802919767 0.22306585660410733 2.1238349545493883e-07 6.672879235760762 0.3598895103820565 VAAGLQIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAAGLQIK 8 0 Q14974;J3QR48 Q14974 KPNB1 Importin subunit beta-1 0 24205400.0 5451900.0 3011500.0 15742000.0 False True 5278832.418719178 4214007.654765039 11618697.950122897 1.0 0.7982840371711399 2.200997688224015 22.331787436408614 -6.870413745226941 1.1318377237309387 0.8856140816162966 2.283819823263082 0.9650977883926487 0.11567998240995864 0.13646226420863727 0.32646866756150056 0.07929618381336623 0.18788247025219443 1.34767835975646e-07 6.870413745226941 1.3982057416467852 up VAAGLQIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAAGLQIK 8 0 Q14974;J3QR48 Q14974 KPNB1 Importin subunit beta-1 0 42364000.0 10971000.0 18712000.0 12681000.0 False True 16643809.087535333 15372697.402476689 10174594.79172026 1.0 0.9236285589210111 0.6113140770966957 23.988482309398407 -6.944367644377067 0.6176021292939932 1.0034245588724777 0.515040348714024 0.9986817455815609 0.006104907991977626 0.08582955501065295 0.0459532012558381 0.0061616267969939785 0.02640754028663316 1.1366646549027933e-07 6.944367644377067 -0.4883842101584537 VAAGLQIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAAGLQIK 8 0 Q14974;J3QR48 Q14974 KPNB1 Importin subunit beta-1 0 32984100.0 13038000.0 7623100.0 12323000.0 False True 17858500.93870178 7286286.235779358 9412561.200151537 1.0 0.40800099968015757 0.5270633426881451 24.09010764841829 -10.663920336392376 7.767995013686702 1.0013050532187846 0.4675321711846875 0.9638560550254073 0.048606997991633 0.0011006878599586947 4.762082352408921e-05 0.047153148214528554 0.01568784114422767 2.1681017681002766e-11 10.663920336392376 -0.5337728820340971 VAAGLQIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAAGLQIK 8 0 Q14974;J3QR48 Q14974 KPNB1 Importin subunit beta-1 0 18983400.0 5451900.0 8303600.0 5227900.0 False True 4533496.410121443 8258866.858664457 6321029.718921504 1.0 1.821743332635223 1.3942946342273992 22.11219271184289 -10.179691669598613 4.34844497613236 0.9998466931064479 1.6080189834548693 0.7295667814546805 0.17450520059375202 123396970.36909255 69730515.94148812 218522.64481269635 0.06386236544096266 6.611626784835987e-11 10.179691669598613 0.6081722903484214 VAAIEALNDGELQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAAIEALNDGELQK 14 0 P50502;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P4 Hsc70-interacting protein;Putative protein FAM10A4 0 28432000.0 2422000.0 13676000.0 12334000.0 False True 3175265.454681365 11635594.108630471 11057795.99608232 1.0 3.664447673650672 3.4824792301316303 21.59844577668729 -10.077390335288776 4.820624973760621 0.9999085759675587 3.573463451920789 0.9962641286550419 0.07428830608703747 4803958.6683180705 10042556.717031473 2937.45313702996 0.02543086332601982 8.367768655559925e-11 10.077390335288776 2.5735548759532305 VAAIEALNDGELQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAAIEALNDGELQK 14 0 P50502;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P4 Hsc70-interacting protein;Putative protein FAM10A4 0 30582300.0 7737500.0 3513800.0 19331000.0 False True 7491877.297793366 4916878.664224933 14267631.182430787 1.0 0.6562946066499428 1.9044133553325988 22.83689584059298 -6.833286179059645 1.3132332787094474 0.8167274877401336 1.9402934871366666 0.9122770925710747 0.15591020348317033 0.17679011223436997 0.595122288736211 0.09318456883366796 0.2144410820590078 1.4679586451156062e-07 6.833286179059645 1.123565999396533 VAAIEALNDGELQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAAIEALNDGELQK 14 0 P50502;Q3KNR6;H7C3I1;Q8IZP2;F6VDH7 P50502 ST13;ST13P4 Hsc70-interacting protein;Putative protein FAM10A4 0 25362000.0 2422000.0 11693000.0 11247000.0 False True 3317478.85208895 11176364.596419837 8590690.239235932 1.0 3.3689331853260507 2.589523738433644 21.66165583821018 -10.079311141801561 5.599971146682379 0.9999861750084664 2.9792284618803673 0.8958120185799419 0.31819257426704395 5.49215358642939e-05 9.030266288496683e-06 0.30809077833762066 0.10269621175166084 8.330841239150834e-11 10.079311141801561 1.9792422868719008 VAALFPALRPGGFQAHYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAALFPALRPGGFQAHYR 18 1 Q13501;E7EMC7;E3W990;D6RBF1;C9J6J8 Q13501 SQSTM1 Sequestosome-1 0 37623700.0 13995000.0 16589000.0 7039700.0 False True 18347580.527772784 14113985.86341553 6311299.373570679 1.0 0.7692559704017187 0.34398537529333895 24.129086493453237 -6.961611214216902 0.41209779565338606 1.0204759424556318 0.07692912682753136 0.9998253667530239 0.003590656050294666 0.07913050374459159 0.019041138364740823 0.005479721854229038 0.03548318011634124 1.0924178447891144e-07 6.961611214216902 -0.9435468156281004 down VAALFPALRPGGFQAHYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAALFPALRPGGFQAHYR 18 1 Q13501;E7EMC7;E3W990;D6RBF1;C9J6J8 Q13501 SQSTM1 Sequestosome-1 0 43343000.0 17746000.0 8859000.0 16738000.0 False True 17182662.943669297 12396444.89907468 12353815.670763373 1.0 0.7214507401858784 0.7189697959660529 24.03445030475724 VAALFPALRPGGFQAHYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAALFPALRPGGFQAHYR 18 1 Q13501;E7EMC7;E3W990;D6RBF1;C9J6J8 Q13501 SQSTM1 Sequestosome-1 0 55741000.0 14173000.0 15728000.0 25840000.0 False True 21501477.185091466 12921215.516575115 20732712.67392567 1.0 0.6009454794824205 0.9642459676352454 24.357932442835498 -10.381827156766834 8.435732420765174 1.0000013259507319 0.782595723558833 0.32316571918901005 0.1483168032130777 3.698681044556475e-06 2.7092549374544496e-07 0.14360800447477406 0.04786904240058106 4.1511922150587014e-11 10.381827156766834 -0.21740560239189888 VAALFPALRPGGFQAHYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAALFPALRPGGFQAHYR 18 1 Q13501;E7EMC7;E3W990;D6RBF1;C9J6J8 Q13501 SQSTM1 Sequestosome-1 0 42432000.0 13995000.0 13453000.0 14984000.0 False True 19169329.70065435 12858601.976878151 11445087.805166822 1.0 0.6707903811805803 0.5970520609688371 24.192296554976128 -13.999999999386615 0.21023521851412952 2.9057793050376106 0.5537191363514892 0.9994901441671957 0.003955493990767601 12.752185616169147 0.1453279313928798 10.039794658582382 0.043607053673870085 1.0000000014123709e-14 13.999999999386615 -2.3520601686861213 VAALFPALRPGGFQAHYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAALFPALRPGGFQAHYR 18 1 Q13501;E7EMC7;E3W990;D6RBF1;C9J6J8 Q13501 SQSTM1 Sequestosome-1 0 32979300.0 17746000.0 8355500.0 6877800.0 False True 14756585.281097455 8310487.263063102 8315916.180645833 1.0 0.5631714319239205 0.5635393298812944 23.814855580191516 -10.289179507588479 8.022464963808474 1.0000008661475916 0.5633553818508871 0.9999994667868802 0.00015019371216504099 2.3268165424430936e-09 2.0609902205090116e-10 0.00014542472465565645 4.84748121609197e-05 5.138312250545464e-11 10.289179507588479 -0.4366454842967046 VAALFPALRPGGFQAHYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAALFPALRPGGFQAHYR 18 1 Q13501;E7EMC7;E3W990;D6RBF1;C9J6J8 Q13501 SQSTM1 Sequestosome-1 0 93318000.0 14173000.0 48855000.0 30290000.0 False True 18347227.891597304 46136176.3030035 24777530.801645704 1.0 2.514612920033169 1.3504781729447728 24.129058764927947 -6.579593244879528 2.2678420255300487 2.031676982113192 1.3533049937635386 0.0 0.6580646803862 0.7008132329975788 6.778487703453991 0.24367132959707083 0.7359265382853186 2.6327326240543187e-07 6.579593244879528 -0.6783719883496535 VAALTGLPFVTAPNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAALTGLPFVTAPNK 15 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 10070000.0 2251600.0 6280800.0 1537600.0 False True 2951869.4045254146 5343729.1223666435 1378503.9017006804 1.0 1.8102864287201685 0.46699352606431066 21.493197464973413 -6.74336626634336 1.6742333766883932 1.4802213348956461 0.46559008904505117 0.620028190785905 0.3404342039648831 0.3117530168871875 1.7170384316733884 0.16077403478158733 0.3930977758701617 1.8056506711843332e-07 6.74336626634336 -1.014631245850595 VAALTGLPFVTAPNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAALTGLPFVTAPNK 15 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 11346500.0 5790900.0 2000300.0 3555300.0 False True 5607071.049278401 2799030.221426694 2624060.2732862355 1.0 0.49919649614336775 0.467991264998138 22.418815920168562 -13.999999999999998 0.39475320265644415 9.1625278743965 0.4659300932647099 0.9998302153519698 0.003176343689612858 26.010412842680655 0.206464197001883 181.49028845911852 0.008102300289331165 1.0000000000000041e-14 13.999999999999998 -8.696597781131791 VAALTGLPFVTAPNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAALTGLPFVTAPNK 15 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 11463400.0 2251600.0 4582100.0 4629700.0 False True 3084077.3672020943 4379647.6710215835 3536260.2116644965 1.0 1.4200835937507117 1.146618515239333 21.556407526496304 -10.21035918026085 4.792131939845946 0.9999534229831273 1.2833510544950422 0.5887275004132277 0.1116416508067945 5.5576311172887267e-05 9.157759604675149e-06 0.10811430726936369 0.03603218785939799 6.160852620283262e-11 10.21035918026085 0.2833976315119149 VAALTGLPFVTAPNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAALTGLPFVTAPNK 15 0 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 8858000.0 5790900.0 1324600.0 1742500.0 False True 4815389.930367814 1317464.1168874858 2106848.6935902964 1.0 0.2735944826770973 0.4375240061669043 22.19922119560284 -10.387407987394274 8.817611054054963 1.0000025561415398 0.35555924443760983 0.9537162229016642 0.06692394772126939 3.36300970163198e-06 2.3357732043555294e-07 0.06479909138106614 0.021599611248911004 4.098189276633457e-11 10.387407987394274 -0.6444433117039299 VAASIGNAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAASIGNAQK 10 0 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 0 5865670.0 953870.0 3042400.0 1869400.0 False True 1250532.8072902192 2588485.7791823144 1675972.4205510188 1.0 2.069906334397821 1.3402066789296676 20.254111475938654 -10.248450070423951 4.937497777009355 0.9998627708890994 1.705056506664397 0.5545252899568596 0.2978986368992213 0.00045009903023601186 6.851111484861783e-05 0.2884945408209701 0.0961463716303893 5.6435181950626816e-11 10.248450070423951 0.7051937357752976 VAASIGNAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAASIGNAQK 10 0 O00151 O00151 PDLIM1 PDZ and LIM domain protein 1 0 5584570.0 953870.0 1865800.0 2764900.0 False True 1306541.5163674995 1783362.7866244873 2111887.564902943 1.0 1.364949191651151 1.6163952989220731 20.317321537461545 -7.453913801797263 0.07646657451270977 8.742054995044223e-16 2.867188861714778 0.999999256959296 0.0002180611874004561 0.13095527031329104 0.006059323410036488 0.09547089309694318 0.1274087646587111 3.516302247114407e-08 7.453913801797263 2.867188861714777 VAASNIVQMK(ub)DDHDK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VAASNIVQMKDDHDK 15 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 103495700.0 51460200.0 35836200.0 16199300.0 True False 67464820.54128572 30489578.64841351 14523151.830658041 1.0 0.4519329986174814 0.21526999870651792 26.007632070657408 -10.286565977737693 0.19227128704578172 1.7284758917749476 1.8485027217311563e-15 0.9994507758285642 0.00770244436387445 1.9170054384492077 0.09415001334438 0.839068082250711 0.14981117720316192 5.169327199175473e-11 10.286565977737693 -1.7284758917749459 VAASNIVQMK(ub)DDHDK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VAASNIVQMKDDHDK 15 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 203024400.0 48615300.0 51573200.0 102835900.0 True False 47072033.91216986 72166647.71068513 75900092.7791286 1.0 1.5331108879921882 1.6124243307766997 25.488366855280056 -11.626832411846108 0.3206475049831185 1.1677355515203199e-15 1.6300140771810994 0.999457687849133 0.006332822221756108 4.216636524608447 0.16954967233238435 2.91059913534161 0.026302118936887817 2.3613892844181047e-12 11.626832411846108 1.6300140771810983 VAASNIVQMK(ub)DDHDK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VAASNIVQMKDDHDK 15 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 960390400.0 91805800.0 194024400.0 674560200.0 True False 139276110.50300357 159399229.90044346 541233080.7997607 1.0 1.1444836399061125 3.8860439083563345 27.05337257831212 -6.917809532622362 0.840816435535855 0.9346010021075579 4.306607394997336 0.9935503258235784 0.1066314113913092 0.09947816807832927 0.1124209335015504 0.09082337476285081 0.26661288242932213 1.2083436589862669e-07 6.917809532622362 3.372006392889778 up VAASNIVQMK(ub)DDHDK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VAASNIVQMKDDHDK 15 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 125242300.0 51460200.0 26688300.0 47093800.0 True False 70486426.59961513 25509122.65959393 35971214.367256105 1.0 0.36190120410690835 0.5103282447780169 26.0708421321803 -10.175352221128628 8.029154204660141 1.0000001348859053 0.4361147244438127 0.950602521809671 0.06059508561259032 1.4632163937892677e-07 1.5135206956433306e-08 0.05867095334776855 0.019556979786631245 6.678020976154548e-11 10.175352221128628 -0.5638854104420926 VAASNIVQMK(ub)DDHDK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VAASNIVQMKDDHDK 15 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 208231400.0 48615300.0 98766800.0 60849300.0 True False 40425775.9729594 98234723.64472504 73572607.29462497 1.0 2.4300021775817924 1.819942982512873 25.268772130714332 -10.238089762332033 5.44012192261372 0.9999194144173807 2.12497258004742 0.8192979047260476 0.2490556234689532 0.0002434411029716691 3.409487441222738e-05 0.24116409457597013 0.08038235683116894 5.7797657573544956e-11 10.238089762332033 1.1250531656300393 VAASNIVQMK(ub)DDHDK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VAASNIVQMKDDHDK 15 1 P49721 P49721 PSMB2 Proteasome subunit beta type-2 1 831053500.0 91805800.0 215269000.0 523978700.0 True False 118844417.86286625 203289090.91334087 428619953.0754796 1.0 1.7105480810038107 3.606563613026076 26.82449890040457 -6.954050142813475 0.5124545471595227 0.9657978171288204 4.434843880687492 0.9994819906492255 0.025040314006477243 0.0818990252625432 0.02953851778210438 0.02872083425117327 0.15650979209519916 1.1116033762641229e-07 6.954050142813475 3.4690460635586713 VAASVLNPYVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAASVLNPYVK 11 0 P48047;A0A494C0K9;H7C0C1 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 10292770.0 919870.0 6699700.0 2673200.0 False True 1205958.4780337512 5700130.875226065 2396602.9071450643 1.0 4.726639415081532 1.9873013464382232 20.201748804451025 -6.567035419285872 2.3172398816509534 3.5570679499055426 1.9923696954870402 0.0 1.624217619527869 0.7391618866482051 7.446076939966692 0.593319336195027 1.8235176274991236 2.7099706087328605e-07 6.567035419285872 -1.5646982544185024 VAASVLNPYVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAASVLNPYVK 11 0 P48047;A0A494C0K9;H7C0C1 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 6037100.0 2449500.0 1039800.0 2547800.0 False True 2371741.9632885084 1454997.5624853678 1880454.7476383646 1.0 0.613472116700233 0.7928580666638138 21.17751562788684 -10.23574185629134 5.979097289527006 1.0000079972574212 0.7031650916820219 0.7849847013495702 0.0732340074058731 7.807327053552846e-06 9.97896877800354e-07 0.07091043282622224 0.02363617425491402 5.811097252605098e-11 10.23574185629134 -0.2968429055753993 VAASVLNPYVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAASVLNPYVK 11 0 P48047;A0A494C0K9;H7C0C1 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 8956670.0 919870.0 4138900.0 3897900.0 False True 1259970.7975520482 3956029.712487987 2977296.2997704037 1.0 3.139778890252071 2.3629883371542304 20.264958865973917 -10.270864212385924 5.697709837214837 0.9998772625399956 2.7513836137031737 0.8714301462604083 0.31712341535075433 0.0004944666433858771 6.327650904771743e-05 0.3070741372772613 0.10235114219547878 5.359642072469498e-11 10.270864212385924 1.751506351163178 VACIGAWHPAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VACIGAWHPAR 11 0 P39023;G5E9G0;B5MCW2;H7C422;Q92901 P39023 RPL3;RPL3L 60S ribosomal protein L3;60S ribosomal protein L3-like 0 48533000.0 16457000.0 16898000.0 15178000.0 False True 21575286.36981471 14376884.267888088 13607526.157656685 1.0 0.6663589081256565 0.6306996776040266 24.362876372703585 -13.999999999999998 0.31583639978266187 4.337627478670899 0.6232866346099922 0.9996847438229505 0.002953138576820403 17.69597975639654 0.17904559423482866 38.939423285312245 0.012069025131634234 1.0000000000000041e-14 13.999999999999998 -3.7143408440609065 VACIGAWHPAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VACIGAWHPAR 11 0 P39023;G5E9G0;B5MCW2;H7C422;Q92901 P39023 RPL3;RPL3L 60S ribosomal protein L3;60S ribosomal protein L3-like 0 14408600.0 7258500.0 2108200.0 5041900.0 False True 7028082.890602032 2950015.2541177613 3721275.1362421922 1.0 0.41974679297857004 0.5294865177555447 22.744699776201948 -9.976204288707866 5.93654581906872 1.0000004392038626 0.4746166553673427 0.9683150459135156 0.044801055036572446 2.6046863672218466e-07 4.4968763145783957e-08 0.04337847120830977 0.0144594783373724 1.0563205074729054e-10 9.976204288707866 -0.5253837838365198 VACIGAWHPAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VACIGAWHPAR 11 0 P39023;G5E9G0;B5MCW2;H7C422;Q92901 P39023 RPL3;RPL3L 60S ribosomal protein L3;60S ribosomal protein L3-like 0 61298000.0 10411000.0 50887000.0 0.0 False True 15794248.146051442 41805817.268054344 0.0 1.0 2.646901383432157 0.0 23.912895926286506 -6.738871391931702 1.6938842959654212 1.9816188966130595 8.581611499407945e-05 0.5979100768827506 0.6919978332905118 0.32022512387109403 1.8041984375228335 0.3234310024402556 0.7937202444732002 1.8244358943958528e-07 6.738871391931702 -1.9815330804980653 VACIGAWHPAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VACIGAWHPAR 11 0 P39023;G5E9G0;B5MCW2;H7C422;Q92901 P39023 RPL3;RPL3L 60S ribosomal protein L3;60S ribosomal protein L3-like 0 56979000.0 16457000.0 12710000.0 27812000.0 False True 22541597.63370266 12148430.17365058 21243378.406119797 1.0 0.5389338577975091 0.9424078431050577 24.426086434226477 -10.224541251131514 7.941292465940511 1.0000001801800138 0.7406708504512834 0.3551801729328814 0.16471756474844845 5.254204073083268e-07 5.1473478138680834e-08 0.1594872055939327 0.05316236542488188 5.96291678831941e-11 10.224541251131514 -0.25932932972873035 VACIGAWHPAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VACIGAWHPAR 11 0 P39023;G5E9G0;B5MCW2;H7C422;Q92901 P39023 RPL3;RPL3L 60S ribosomal protein L3;60S ribosomal protein L3-like 0 13026500.0 7258500.0 1590400.0 4177600.0 False True 6035764.356071562 1581832.199530316 5051116.844960014 1.0 0.2620765335113029 0.8368644875737967 22.525105051636224 -10.235197150405718 7.570456115335104 1.000000730830742 0.5494705105436175 0.45029638446409403 0.23465619962523454 2.894349908894959e-06 2.9247914066475356e-07 0.2272052573035465 0.07573496276940471 5.818390287335346e-11 10.235197150405718 -0.4505302202871244 VACIGAWHPAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VACIGAWHPAR 11 0 P39023;G5E9G0;B5MCW2;H7C422;Q92901 P39023 RPL3;RPL3L 60S ribosomal protein L3;60S ribosomal protein L3-like 0 25196500.0 10411000.0 8936300.0 5849200.0 False True 13477244.73149082 8438987.049360974 4784705.617860221 1.0 0.6261656011664243 0.35502105312967397 23.684022248378955 -7.941250336625184 0.20105362449945513 1.2422218040409025 1.046608363833136e-16 0.9998531300068567 0.003204519160553207 0.11080191889818694 0.03321405240532866 0.07184430967214608 0.09946048169586298 1.1448528335618667e-08 7.941250336625184 -1.2422218040409025 down VACITEQVLTLVNK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VACITEQVLTLVNKR 15 1 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 1 6995000.0 1585000.0 1285200.0 4124800.0 True False 1317997.727405583 1278276.3725077747 4987276.609079637 1.0 0.9698623494776445 3.7839796726333192 20.32991645206504 -6.904478545520354 0.932504976981383 0.8969371689463956 4.107790669346087 0.9886661287925552 0.14047925080120632 0.10818386539643016 0.1594050954260077 0.1119605774402701 0.29843072001260545 1.2460097895871847e-07 6.904478545520354 3.2108535003996908 up VACVQVVIIPCGITNALSEEDKEALIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VACVQVVIIPCGITNALSEEDKEALIAK 28 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 180898000.0 48526000.0 68142000.0 64230000.0 False True 73617489.72579901 55981527.70412391 51534912.346990965 1.0 0.7604378784530242 0.7000362622923113 26.133545220482194 -13.999999999999998 0.19347704591589004 2.300000896095392 0.658187509017069 0.9994878682800881 0.0029314406012214997 12.409458936357996 0.13948957419601601 6.089263723167466 0.040418927398057275 1.0000000000000041e-14 13.999999999999998 -1.641813387078323 VACVQVVIIPCGITNALSEEDKEALIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VACVQVVIIPCGITNALSEEDKEALIAK 28 1 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 104291000.0 48526000.0 20189000.0 35576000.0 False True 62817863.59046437 19065464.402442697 29101533.040585905 1.0 0.303503865186157 0.46326842998531176 25.904671542574643 -10.320784135580407 8.592354670243122 1.000000899393353 0.38338614759215994 0.952064001459855 0.06522361045595798 1.1238379877530315e-06 8.871247156334049e-08 0.06315258147124843 0.02105082975628711 4.77766686763755e-11 10.320784135580407 -0.616614751801193 VADEDSVK(ub)VLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VADEDSVKVLDK 12 1 E9PC61;G4U4J3;Q8NDF8-2;Q8NDF8;Q8NDF8-3;Q8NDF8-5;Q8NDF8-4 E9PC61 PAPD5 Non-canonical poly(A) RNA polymerase PAPD5 1 3016610.0 874550.0 1222100.0 919960.0 True False 727227.0741341019 1215516.304732144 1112319.3825855544 1.0 1.6714398404094633 1.5295351646663815 19.47204638545386 -10.031751447587387 4.516950575554186 0.9999757653498679 1.6004875025155965 0.959799873159279 0.05793234144787997 8624488.009425534 6384744.545811027 1917.448930218326 0.019831781617130964 9.294981985609757e-11 10.031751447587387 0.6005117371657286 VADEDSVK(ub)VLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VADEDSVKVLDK 12 1 E9PC61;G4U4J3;Q8NDF8-2;Q8NDF8;Q8NDF8-3;Q8NDF8-5;Q8NDF8-4 E9PC61 PAPD5 Non-canonical poly(A) RNA polymerase PAPD5 1 17068800.0 1435300.0 1326500.0 14307000.0 True False 1858024.1439927754 1252679.1089127858 11703272.802216757 1.0 0.674199586137163 6.2987732640907295 20.825337818188082 -6.893163904836933 1.0035137222398387 0.7203054569610041 6.813557648612256 0.982846131869956 0.3376597194856148 0.11661226865166205 0.20716969344883354 0.25526194806191427 0.6440430153068251 1.2788985505710603e-07 6.893163904836933 6.093252191651252 up VADGFK(ub)VVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VADGFKVVAR 10 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 4595100.0 0.0 2551700.0 2043400.0 True False 0.0 2170996.3064486952 1831968.5696768789 0.0 VADGFK(ub)VVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VADGFKVVAR 10 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 14589500.0 5412300.0 4322000.0 4855200.0 True False 5240489.499043237 6047797.138932255 3583477.4671221385 1.0 1.154051952596491 0.6838058673290689 22.32127014537301 -6.818460940984082 1.3785546872243055 1.0831640364580601 0.673877563274012 0.8808007755272229 0.06758115477875924 0.19548817913462896 0.7304122576928723 0.03852813382885363 0.08883817369088498 1.5189345438612002e-07 6.818460940984082 -0.4092864731840481 VADGFK(ub)VVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VADGFKVVAR 10 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 4696900.0 0.0 2805900.0 1891000.0 True False 0.0 2681926.060129515 1444384.7463674867 0.0 VADGFK(ub)VVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VADGFKVVAR 10 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 15252300.0 5412300.0 7360100.0 2479900.0 True False 4500567.255543994 7320449.680434534 2998435.624237921 1.0 1.6265615565275438 0.6662350441590043 22.101675420807286 -6.730652102743272 1.7210091757538095 1.376785193591592 0.6667525990570706 0.5622597104161801 0.2633771234140751 0.3349958228928914 1.9441683712711746 0.12126513310900816 0.3006712950948941 1.8592932698086896e-07 6.730652102743272 -0.7100325945345214 VADGFK(ub)VVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VADGFKVVAR 10 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 30330800.0 8807400.0 8461400.0 13062000.0 True False 11401352.919809092 7990515.651831621 10684850.027437977 1.0 0.7008392519758451 0.9371563271998854 23.442701693416325 -9.882060999822071 5.868970220626002 1.0000000497202601 0.8189977903761544 0.43889488184105463 0.09647604196829963 6.268129234972146e-08 1.2095775895624194e-08 0.09341255101767086 0.031137508654172186 1.312015603932385e-10 9.882060999822071 -0.18100225934410574 VADISGDTQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VADISGDTQK 10 0 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 6655790.0 2304900.0 756890.0 3594000.0 False True 2231732.21113847 1059120.124129206 2652623.582311121 1.0 0.4745731225472247 1.188594029817736 21.089732495756408 -6.709514729920606 1.796882865612925 0.6768204748482192 1.1868964995985283 0.46281957009434616 0.22142868897176388 0.37605242091921787 2.366551664401708 0.09807495985039975 0.24930804708178533 1.9520245263084468e-07 6.709514729920606 0.5100760247503091 VADISGDTQK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VADISGDTQKAK 12 1 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 9296260.0 362300.0 8211710.0 722250.0 True False 474978.80851819064 6986554.87699487 647518.4983112088 1.0 14.709192813866979 1.3632576584443772 18.857503622558884 -6.6399173699844685 2.0446038895934793 9.965568637033455 1.4185989493718427 0.15432380481667207 5.865874923151498 0.5335961715558206 4.263100416316682 2.3363197385530996 6.496053447233623 2.2913035607670424e-07 6.6399173699844685 -8.546969687661612 VADISGDTQK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VADISGDTQKAK 12 1 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 10877530.0 578380.0 5748450.0 4550700.0 True False 560019.6434892057 8043836.062770737 3358735.1519263233 1.0 14.363489131655397 5.997530963377827 19.09511790708461 -9.43597992549 8.325849887496023 1.0000679376985655 10.18051004751775 0.616213208700306 3.4153881205208907 0.0 0.0 3.3069352785255544 1.1023117759331271 3.664545129813281e-10 9.43597992549 9.180442109819184 VADISGDTQK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VADISGDTQKAK 12 1 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 47487900.0 8688800.0 9937200.0 28861900.0 True False 13181544.836366538 8163829.020302028 23157332.81437984 1.0 0.6193378030910958 1.7567996089874929 23.652016123871604 -6.816466148313169 1.387120025076512 0.7940648770344235 1.779794488962553 0.8760578618553518 0.16643508351877617 0.1981124278238724 0.7499512255315216 0.09431112315322877 0.21760059021696 1.525927330698139e-07 6.816466148313169 0.9857296119281295 VADISGDTQK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VADISGDTQKAK 12 1 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 9092320.0 362300.0 4433920.0 4296100.0 True False 496252.10078935826 4238014.753387315 3281449.660956831 1.0 8.540043954768475 6.612465026822511 18.920713684081775 -9.528404133249527 8.07175571307678 0.9999964007187306 7.576254490795833 0.9394646806256367 0.7869308020720854 0.0 0.0 0.7619424727589144 0.2539808242529714 2.9620737453925626e-10 9.528404133249527 6.576258090077102 VADISGDTQK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VADISGDTQKAK 12 1 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 10001930.0 578380.0 8543400.0 880150.0 True False 480948.59657844837 8497375.008467866 1064185.2956461988 1.0 17.667948443803898 2.2126799063704463 18.875523182518887 -6.495663435362484 2.6365101983602672 9.999999999999998 2.188849212722469 0.18984892630592254 6.8295516592333305 0.6341692206779252 8.23774591186 2.5685147312811965 8.761974559109595 3.1940121557270944e-07 6.495663435362484 -7.81115078727753 VADISGDTQK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VADISGDTQKAK 12 1 Q7KZF4;H7C597 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 37971400.0 8688800.0 9042400.0 20240200.0 True False 11247822.881853582 8539182.491091568 16556691.281989763 1.0 0.7591853624284983 1.4719907537574335 23.423142445964054 -6.815576520163525 1.391001823273739 0.8695953837088789 1.4861120421328433 0.8738837383153836 0.10513899960570215 0.19929251220363595 0.7588727467739593 0.059415487874064615 0.13712425127872774 1.5290563118480368e-07 6.815576520163525 0.6165166584239644 VADK(ub)IQLINNMLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VADKIQLINNMLDK 14 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 11254400.0 2751700.0 5391300.0 3111400.0 True False 2664348.7897044304 7544074.205258096 2296431.000000786 1.0 2.831488968114793 0.8619108011963932 21.34535152719833 -6.6624766840233995 1.9640415442411268 2.1764632543010607 0.8700617299842139 0.24629844207549256 0.7793401841009451 0.4785413986495502 3.55111328454565 0.320293754801739 0.8642288586342658 2.175320817377172e-07 6.6624766840233995 -1.3064015243168468 VADLEQENALLKDEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VADLEQENALLKDEK 15 1 Q9ULV0;A0A0A0MR36;Q9ULV0-2 Q9ULV0 MYO5B Unconventional myosin-Vb 0 16080100.0 2032200.0 1029900.0 13018000.0 False True 2664233.8798527955 876242.934518758 11671022.237473613 1.0 0.3288911462109221 4.380629765926729 21.34528930432091 -6.864362889665603 1.163583968927029 0.6307733066136201 4.5937445720909595 0.9587213092281053 0.36024784422180817 0.1423697234311152 0.3638464836646377 0.24102132222462352 0.5656413478869746 1.3665864501574244e-07 6.864362889665603 3.9629712654773392 up VADLEQENALLKDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VADLEQENALLKDEK 15 1 Q9ULV0;A0A0A0MR36;Q9ULV0-2 Q9ULV0 MYO5B Unconventional myosin-Vb 0 4210510.0 2032200.0 640310.0 1538000.0 False True 2783559.258140035 612018.986977985 1174756.0761042822 1.0 0.219869214276018 0.42203379456317025 21.408499365843802 -10.301344870859412 5.131242833709503 1.0001765759968586 0.32095150442445064 0.9376669431784318 0.08253334429500499 0.00016676173620980278 2.2705611844219112e-05 0.07993299335545091 0.02663752233005125 4.9963761791868267e-11 10.301344870859412 -0.679225071572408 VADLVHILTHLQLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VADLVHILTHLQLLR 15 0 D3YTB5;P51617-4;P51617-2;P51617-3;P51617;F8WAB6;H7C1F0 D3YTB5 IRAK1 Interleukin-1 receptor-associated kinase 1 0 321901000.0 81204000.0 132310000.0 108387000.0 False True 123192404.8076036 108698246.75725177 86964261.94229032 1.0 0.8823453599027622 0.7059222691375108 26.876338071266606 -6.965263535052416 0.35351373925010815 1.016374479265759 0.5659078665510288 0.9999184577864627 0.0010912977883693299 0.07787179804545054 0.014546170847496624 0.0024009049013708175 0.015129354595023705 1.0832693738110663e-07 6.965263535052416 -0.4504666127147302 VADLVHILTHLQLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VADLVHILTHLQLLR 15 0 D3YTB5;P51617-4;P51617-2;P51617-3;P51617;F8WAB6;H7C1F0 D3YTB5 IRAK1 Interleukin-1 receptor-associated kinase 1 0 197741000.0 81204000.0 60791000.0 55746000.0 False True 105120178.77014507 57407927.41041626 45600800.00226283 1.0 0.5461171021782979 0.4337968269819363 26.647464393359055 -13.999999999999993 0.19612561856674499 3.486798953559206 0.3580016971555092 0.9994871894052122 0.005542894371562874 12.45697122481324 0.14043664773840342 11.864819546755983 0.07364239437895499 1.0000000000000164e-14 13.999999999999993 -3.128797256403697 VADMALHYANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VADMALHYANK 11 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 25090800.0 4894400.0 8837400.0 11359000.0 False True 6416605.797437019 7518894.367915395 10183679.643221913 1.0 1.1717868613525646 1.5870820126256742 22.6133789236638 -6.956176658872965 0.48633213719152424 0.9906020985843528 1.7857680531458922 0.9996010702004545 0.004922432894636156 0.08109623759200373 0.026400863336677148 0.0059328051905305585 0.03425312768972041 1.1061737318515797e-07 6.956176658872965 0.7951659545615394 VADMALHYANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VADMALHYANK 11 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 13167800.0 3905000.0 1912000.0 7350800.0 False True 3781037.9124889295 2675471.5709482813 5425404.96072693 1.0 0.7076024184023875 1.4348983232372745 21.850350884633333 -6.797582841174765 1.4656960651698085 0.8381704637428982 1.4443559877773937 0.8250089583182296 0.12499841832311602 0.22423256551608875 0.9512374807402826 0.06709848621887392 0.15628624599808222 1.5937388478572175e-07 6.797582841174765 0.6061855240344955 VADMALHYANK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VADMALHYANK 11 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 41694900.0 3217900.0 34067000.0 4410000.0 False True 4881789.560001825 27987477.68331409 3538361.5670283358 1.0 5.733036489861235 0.724808294896475 22.21897867532293 -6.658967490518864 1.9766613661076795 4.049278369842369 0.7458317050256967 0.23109627711711167 2.015739223938952 0.4869590072306024 3.656493675962221 0.8242212687001054 2.2341403850779864 2.1929690857641422e-07 6.658967490518864 -3.3034466648166725 VADMALHYANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VADMALHYANK 11 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 18230800.0 4894400.0 5163700.0 8172700.0 False True 6703991.946186682 4935550.659927574 6242476.582039958 1.0 0.7362107084175391 0.9311581267025179 22.67658898518669 -10.457538404475242 5.033336860807342 1.0003094147384328 0.8336844175600201 0.4924996845487416 0.07958695024521525 0.0002768485381939312 2.983686743339842e-05 0.07720210613836072 0.02568657773959224 3.487077466949057e-11 10.457538404475242 -0.16662499717841273 VADMALHYANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VADMALHYANK 11 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 8450300.0 3905000.0 2629200.0 1916100.0 False True 3247180.5208320473 2615035.9777446636 2316747.6509545897 1.0 0.8053251000269597 0.7134643842840476 21.63075616006761 -13.999999999995152 0.09999039069744478 1.961436741166486 0.5177816960308738 0.9997937637383956 0.0017155677687918042 12.08044953996162 0.09416812900030183 2.3967051444434584 0.17452319953805384 1.0000000000111622e-14 13.999999999995152 -1.4436550451356123 VADMALHYANK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VADMALHYANK 11 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 11994500.0 3217900.0 5526900.0 3249700.0 False True 4165634.9842920336 5219323.1564644305 2658287.9447378037 1.0 1.252947792148302 0.6381471143683489 21.99010499741538 -6.794988423492944 1.4763833586827182 1.1404599392894914 0.6306827234467451 0.8170807343235215 0.10790656531111895 0.22798823927965478 0.9815474234557876 0.057514577992554015 0.13418085784717013 1.6032881271965368e-07 6.794988423492944 -0.5097772158427463 VADPTPFHIQAEVTMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VADPTPFHIQAEVTMK 16 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 9026700.0 1883800.0 2305500.0 4837400.0 False True 1823999.8001399885 3226098.173023667 3570339.8211106886 1.0 1.7686943676068771 1.9574233620182808 20.7986741407473 -10.951247675310057 0.270382713760354 1.7310856620029093e-13 2.0330390711947546 0.9992109624152401 0.011631461959065042 2.8424130843399316 0.1406390424690393 1.8613705221811025 0.07770031067602454 1.1187996573498758e-11 10.951247675310057 2.0330390711945814 VADPTPFHIQAEVTMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VADPTPFHIQAEVTMK 16 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 61760800.0 9167800.0 33124000.0 19469000.0 False True 13908222.855957204 27212763.401006717 15620943.616434157 1.0 1.956595294944593 1.1231444720303252 23.72943475334459 -10.208187724680563 4.320538332853884 0.9998559330906305 1.539869883247863 0.35874599246052763 0.34025487550662326 180957157.23243418 137.70344334470803 368565.56622886896 0.12452053386768014 6.191733782619903e-11 10.208187724680563 0.5400139501572325 VADPTPFHIQAEVTMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VADPTPFHIQAEVTMK 16 0 P16152;E9PQ63;A8MTM1;P16152-2 P16152 CBR1 Carbonyl reductase [NADPH] 1 0 39438800.0 9167800.0 18145000.0 12126000.0 False True 11867897.82435516 17135214.799263112 9919192.423266951 1.0 1.4438289790546077 0.8358002883131418 23.50056107543704 -6.711024791139624 1.7918242291206765 1.272573287454561 0.8372017083845869 0.4698645207715795 0.18699734479358207 0.3730088502420527 2.335195994900129 0.08303530131275436 0.2106654568691132 1.9452490364242303e-07 6.711024791139624 -0.43537157906997415 VADSSK(ub)GPDEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VADSSKGPDEAK 12 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;F6UXX1 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 10619440.0 3236530.0 5475310.0 1907600.0 True False 4243122.172601108 4658415.0905912155 1710219.8509912952 1.0 1.0978743720064805 0.4030569428414314 22.01669478819987 -6.8712334034333775 1.127616657114448 1.0557837179445806 0.3614114188537041 0.9658954216300921 0.056710053142827 0.1356743016904429 0.3216816499078444 0.03900214168300687 0.09253752642959615 1.3451372409507404e-07 6.8712334034333775 -0.6943722990908765 down VADSSK(ub)GPDEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VADSSKGPDEAK 12 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;F6UXX1 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 5136600.0 1916300.0 1634900.0 1585400.0 True False 1855468.1054295888 2287724.0958908685 1170136.1790194898 1.0 1.2329633094723562 0.6306420334552574 20.82335177136525 -6.801838743412634 1.4483652632385344 1.128241104343837 0.621943723961422 0.8374734766673491 0.09997583114236798 0.2181557253733466 0.9032863425645314 0.054297512479618344 0.12613882326506487 1.5781971565947208e-07 6.801838743412634 -0.506297380382415 VADSSK(ub)GPDEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VADSSKGPDEAK 12 1 O60506;O60506-2;O60506-3;O60506-4;B7Z645;F6UXX1 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 4721020.0 1916300.0 2437220.0 367500.0 True False 1593488.3564841126 2424090.212109705 444342.5508719848 1.0 1.521247521041346 0.2788489473825754 20.603757046799526 -6.792682841808955 1.485286425768216 1.2902893346901474 0.26456419873243986 0.8100747775396651 0.22199465896077863 0.23132159455824194 1.008009061266766 0.11762217157666097 0.274891037030278 1.61182229306363e-07 6.792682841808955 -1.0257251359577075 down VADWTGATYQDK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 VADWTGATYQDKR 13 1 O15371-2;O15371-3;O15371;B0QYA5;B0QYA6;B0QYA8 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 1 30012400.0 7805500.0 12213000.0 9993900.0 True False 10233086.088569518 10390868.005901124 8959827.096258083 1.0 1.0154188009331662 0.8755742909527869 23.28673796210501 -6.879557641332327 1.082320264213096 1.0095002519178955 0.8657495168565582 0.973324377696767 0.01022528738694569 0.12802001998067297 0.2746913520604861 0.007280830602569043 0.017586470039307477 1.3196001573767416e-07 6.879557641332327 -0.1437507350613373 VADWTGATYQDK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VADWTGATYQDKR 13 1 O15371-2;O15371-3;O15371;B0QYA5;B0QYA6;B0QYA8 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 1 30318300.0 9878300.0 10286000.0 10154000.0 True False 9564718.773608033 14393253.44078137 7494362.786529526 1.0 1.5048276673326488 0.7835424087123974 23.189291119716195 -6.718574632563897 1.7645670222587353 1.3076037760432493 0.7847669966229348 0.5056931776199618 0.21247198362635067 0.3581116356719 2.1784221770882577 0.09563865874039967 0.2404811005115254 1.911724770623067e-07 6.718574632563897 -0.5228367794203145 VADWTGATYQDK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 VADWTGATYQDKR 13 1 O15371-2;O15371-3;O15371;B0QYA5;B0QYA6;B0QYA8 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 1 57656800.0 22313500.0 14360000.0 20983300.0 True False 33851210.83535871 11797345.804807909 16835941.557692885 1.0 0.34850587360630514 0.49735123625495803 25.012704103179455 -10.156337615253921 7.93888271345204 1.0000001157424947 0.42292855493263876 0.9524745648918256 0.06076586484478627 1.2447832808770283e-07 1.3141749690345483e-08 0.058836307914379694 0.01961209854681234 6.976898176165608e-11 10.156337615253921 -0.577071560809856 VADWTGATYQDK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VADWTGATYQDKR 13 1 O15371-2;O15371-3;O15371;B0QYA5;B0QYA6;B0QYA8 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 1 26599000.0 7805500.0 8402500.0 10391000.0 True False 10691404.285706142 8031249.766648233 7936859.80936255 1.0 0.7511875476812341 0.7423589640112781 23.349948023627903 VADWTGATYQDK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VADWTGATYQDKR 13 1 O15371-2;O15371-3;O15371;B0QYA5;B0QYA6;B0QYA8 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 1 39744930.0 9878300.0 19688600.0 10178030.0 True False 8214244.132889934 19582533.603918888 12306209.015106387 1.0 2.383972680518489 1.4981547682314647 22.96969639515047 -10.07816792808108 4.860552461365838 0.9999743545329031 1.9410637243826003 0.6007715557428709 0.36163364839769 251184137.2967827 2.998297424340558 87477.59921255446 0.12379681673088806 8.352799791602308e-11 10.07816792808108 0.9410893698496973 VADWTGATYQDK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VADWTGATYQDKR 13 1 O15371-2;O15371-3;O15371;B0QYA5;B0QYA6;B0QYA8 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 1 56993400.0 22313500.0 18802000.0 15877900.0 True False 28885265.61484209 17755652.17171368 12988285.12101189 1.0 0.6146958248010815 0.4496508806323086 24.783830425271905 -13.999999999999998 0.11572711594585805 2.843819038768363 0.1703980185924922 0.999714139306875 0.0038988296290425654 11.982127621751415 0.10411942937341472 5.112235587947751 0.24780767525071218 1.0000000000000041e-14 13.999999999999998 -2.673421020175871 VAEAEK(ub)QLGAAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAEAEKQLGAAER 13 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 1 5764600.0 1431100.0 1912900.0 2420600.0 True False 1876185.958792112 1627502.7764257984 2170139.5320347706 1.0 0.8674528070093778 1.1566761396252565 20.83937139746069 -6.782069146567859 1.527554812510588 0.9251516662822957 1.159128472501241 0.7747424434268926 0.056104872864974266 0.24736325898796288 1.1401645394202453 0.028922922542273934 0.06813615647192436 1.6516988006538438e-07 6.782069146567859 0.23397680621894523 VAEAEK(ub)QLGAAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAEAEKQLGAAER 13 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 1 38940500.0 4224300.0 5600200.0 29116000.0 True False 5468439.62340186 5288543.947028556 23817186.755388476 1.0 0.9671029235463346 4.355389909301413 22.382697799284745 -6.904706583129718 0.9310175653023324 0.8767349169487658 4.747114517604954 0.9887663245210926 0.1684755721379537 0.10802377401716663 0.1585192908097512 0.13442052203568935 0.35877258101528003 1.2453557114863382e-07 6.904706583129718 3.8703796006561886 up VAEDEAEAAAAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAEDEAEAAAAAK 13 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5H0E2;H0YFS2;F5H867 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 4160490.0 334390.0 1873300.0 1952800.0 False True 438388.5282373661 1593810.942066208 1750742.9885803105 1.0 3.635612794145098 3.993587595960924 18.741850520747104 -9.998154610719999 0.4733440805699087 1.0192416110301838e-22 3.994655611821347 0.9991187267033972 0.03962637429429389 1.295769858400801 0.21492677354726533 1.937693074220311 0.07633475121940969 1.0042582063524333e-10 9.998154610719999 3.994655611821347 VAEDEAEAAAAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAEDEAEAAAAAK 13 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5H0E2;H0YFS2;F5H867 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 2655090.0 334390.0 1149000.0 1171700.0 False True 458023.01954996824 1098233.3807651068 894968.591918977 1.0 2.3977689633245487 1.953981685895025 18.805060582269995 -10.183222951682119 4.989028719172029 0.9999010451434124 2.175875324611562 0.903482081161435 0.18117539734636917 0.00019942964247860733 3.264956637214425e-05 0.17543685393220063 0.058474108054536386 6.558085105908427e-11 10.183222951682119 1.1759742794681496 VAEDEAEAAAAAK(ub)FTGLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAEDEAEAAAAAKFTGLSK 19 1 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5H0E2;H0YFS2;F5H867 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 1 41186000.0 14148000.0 16881000.0 10157000.0 True False 18548165.009426888 14362420.601622615 9106051.072823744 1.0 0.7743310777278013 0.4909408056374148 24.144773130693878 -6.968041910703193 0.30130859204203797 1.048391250703511 0.20798426608696516 0.9999628272961614 0.001269781141284598 0.07694331553172676 0.011292233130082494 0.004671283767001891 0.02538098732211559 1.0763613365622445e-07 6.968041910703193 -0.8404069846165457 down VAEDEAEAAAAAK(ub)FTGLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAEDEAEAAAAAKFTGLSK 19 1 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5H0E2;H0YFS2;F5H867 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 1 35005000.0 13391000.0 10011000.0 11603000.0 True False 12965910.034862816 14008444.50667534 8563826.217461297 1.0 1.0804058079231886 0.6604878635155442 23.62822013200771 -6.857102136735532 1.2002556755027622 1.0433329882212399 0.6412470907738634 0.950023196896759 0.04068349212028851 0.14981773479188187 0.41177213171558424 0.02646593020400193 0.061593033844370905 1.3896257826395556e-07 6.857102136735532 -0.40208589744737644 VAEDEAEAAAAAK(ub)FTGLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAEDEAEAAAAAKFTGLSK 19 1 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5H0E2;H0YFS2;F5H867 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 1 115935000.0 25631000.0 37148000.0 53156000.0 True False 38884100.877095856 30518649.161351234 42649693.30089754 1.0 0.784861896583748 1.0968414426169681 25.212677043727737 -6.721127107697106 1.7549480149111731 0.8692751212676715 1.0963973462579397 0.5180071237772725 0.09051824401375642 0.35311446099107724 2.1259396191590314 0.040942098301344244 0.10265607274169504 1.900521960802745e-07 6.721127107697106 0.22712222499026824 VAEDEAEAAAAAK(ub)FTGLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAEDEAEAAAAAKFTGLSK 19 1 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5H0E2;H0YFS2;F5H867 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 1 34211300.0 14148000.0 12283000.0 7780300.0 True False 19378897.93532388 11740296.445550732 5942753.380308282 1.0 0.6058289013510157 0.30666105988802506 24.20798319221677 -7.883475966077978 0.23584109681720064 1.183457150425398 2.1152973103788733e-11 0.9997446206036188 0.004537506987846262 0.11520986332395726 0.03793687501275643 0.05867527319940622 0.09177683713772346 1.307747907883881e-08 7.883475966077978 -1.1834571504042448 down VAEDEAEAAAAAK(ub)FTGLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAEDEAEAAAAAKFTGLSK 19 1 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5H0E2;H0YFS2;F5H867 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 1 40077000.0 13391000.0 12096000.0 14590000.0 True False 11135209.821885271 12030836.447131995 17640701.543461964 1.0 1.0804319487080027 1.5842271340761558 23.408625407441985 -6.934931498779236 0.705136044097799 0.9935580822376583 1.701966045063975 0.9974218523786624 0.013127637962458716 0.09015665136560397 0.06571976142642984 0.012332619966871388 0.04441387259467029 1.1616318234506276e-07 6.934931498779236 0.7084079628263168 VAEDEAEAAAAAK(ub)FTGLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAEDEAEAAAAAKFTGLSK 19 1 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;F5H0E2;H0YFS2;F5H867 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 1 98230000.0 25631000.0 26418000.0 46181000.0 True False 33179834.76254362 24947815.07671163 37776531.85707493 1.0 0.7518969053117457 1.1385388784310788 24.983803365820187 -6.7333488738712735 1.710583140409339 0.8512621124795331 1.1384743717707375 0.5749961760104993 0.1042715245736004 0.3299530741362886 1.892836591169287 0.04827230724992552 0.11935295426945691 1.847783676236555e-07 6.7333488738712735 0.2872122592912044 VAEELALEQAKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAEELALEQAKK 12 1 C9JRZ6;Q9NX63;F8WAR4;A0A286YEX5 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 13326300.0 5144500.0 4876600.0 3305200.0 True False 6744489.319408872 4149030.288837921 2963209.609717147 1.0 0.6151733796802227 0.439352702537434 22.685277778361538 -13.999999999986892 0.10535313681750277 2.874227729860721 0.0941156139987436 0.9997666832730527 0.0035761835864711222 12.042003107260102 0.09770253009466101 4.845698103916071 0.307105695855389 1.0000000000301817e-14 13.999999999986892 -2.7801121158619773 VAEELALEQAKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAEELALEQAKK 12 1 C9JRZ6;Q9NX63;F8WAR4;A0A286YEX5 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 14780100.0 7823000.0 1021300.0 5935800.0 True False 7574663.147093705 1429110.4160091416 4381035.909817019 1.0 0.18866983102178897 0.5783802955644255 22.852750301233435 -10.732111261323396 6.401708217661013 1.0118841981637188 0.3835250633404235 0.7693969650260029 0.15909863092540927 0.02668612006842103 0.0011167177982060422 0.15233633244865327 0.05134886233154252 1.853056830444153e-11 10.732111261323396 -0.6283591348232953 VAEELALEQAKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAEELALEQAKK 12 1 C9JRZ6;Q9NX63;F8WAR4;A0A286YEX5 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 11914600.0 5144500.0 3900800.0 2869300.0 True False 7046560.674885058 3728449.757779397 2191630.435088435 1.0 0.529116249728484 0.3110212962331705 22.74848783988443 -11.243317038004367 0.1421107164251796 2.082190791977289 1.4383816765797445e-16 0.9996849167431876 0.005103572186074762 3.699895813665198 0.08666502485420566 1.4958441351397445 0.22100957559421 5.7106160551294285e-12 11.243317038004367 -2.082190791977289 VAEELALEQAKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAEELALEQAKK 12 1 C9JRZ6;Q9NX63;F8WAR4;A0A286YEX5 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 11550500.0 7823000.0 1510900.0 2216600.0 True False 6505171.117661748 1502760.4818098298 2680080.8115995703 1.0 0.23101013864643574 0.41199236163412595 22.63315557666771 -10.713949133926823 10.144703032058757 1.0008504483901266 0.32150125018756615 0.9493409309069689 0.07388568313907418 0.0014224017335337843 4.0107514047806275e-05 0.07160090117491535 0.023846501693399372 1.9321946090861683e-11 10.713949133926823 -0.6793491982025605 VAEFHTELER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAEFHTELER 10 0 R4GMR5;P48556;K7EJR3;K7EJC1;K7ERW6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 5820780.0 792380.0 2303300.0 2725100.0 False True 1038817.8534188354 1959656.6181930793 2443132.793005023 1.0 1.8864294753345712 2.351839434569276 19.98651128323315 -9.434571499133153 0.1785640528169735 6.793330779069597e-16 2.9101983898247195 0.9996339348523373 0.01072848295576801 0.8734493254187685 0.0697218310368311 0.7699303267963014 0.3078070369587891 3.676448619785613e-10 9.434571499133153 2.9101983898247186 VAEFHTELER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAEFHTELER 10 0 R4GMR5;P48556;K7EJR3;K7EJC1;K7ERW6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 5029680.0 1819100.0 710380.0 2500200.0 False True 1761353.6662249963 994038.4385827607 1845322.6156077527 1.0 0.5643605016096647 1.0476729636942943 20.74825318961205 -6.669276589497696 1.9402240112596874 0.7217517013776661 1.0456996278383213 0.27568693477902784 0.18508272588751243 0.4628034602925439 3.3582085837798035 0.0768203045001703 0.20541697394453817 2.141526291043085e-07 6.669276589497696 0.3239479264606552 VAEFHTELER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAEFHTELER 10 0 R4GMR5;P48556;K7EJR3;K7EJC1;K7ERW6 R4GMR5 PSMD8 26S proteasome non-ATPase regulatory subunit 8 0 5039980.0 792380.0 1878700.0 2368900.0 False True 1085344.2992643442 1795692.8219698926 1809414.6090269403 1.0 1.654491411791658 1.6671342082446807 20.04972134475604 -11.274832109263864 0.6440759481868799 2.817006604598843e-10 1.6652700079663785 0.9999632774671771 0.001887974329747045 3.842186446109252 0.32348933007674024 5.496706259344655 0.002085995285928225 5.310897146506015e-12 11.274832109263864 1.6652700076846778 VAEIEHAEKEK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAEIEHAEKEK 11 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 12895400.0 3189200.0 5909500.0 3796700.0 True False 4181072.084256736 5027825.635050587 3403853.904518058 1.0 1.202520677407641 0.8141103133176804 21.995441485871314 -6.764992080244858 1.5934322520432154 1.1169009410698008 0.8123175056088634 0.7111099395649911 0.0852538790259735 0.2746062278296904 1.3751465068809767 0.04219129290862918 0.10090900507051052 1.7179397150661928e-07 6.764992080244858 -0.30458343546093736 VAEIEHAEKEK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAEIEHAEKEK 11 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 13657100.0 6077700.0 7579400.0 0.0 True False 9220315.239386883 6226796.851877514 0.0 1.0 0.6753344858837574 0.0 23.136384646066144 -7.479352390465639 0.724080128512523 0.9924659432835672 3.528955133675627e-17 0.9871306417247152 0.047252632406260826 0.11807832344718033 0.14158584346565634 0.04154485358434748 0.07509830200124859 3.316252646192768e-08 7.479352390465639 -0.9924659432835672 down VAEIEHAEKEK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAEIEHAEKEK 11 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 11902800.0 3189200.0 3772700.0 4940900.0 True False 4368333.424889383 3606009.6393494527 3773961.1810296807 1.0 0.8254886448922488 0.8639361545817091 22.058651547394206 -10.58218924279458 6.3994509242490105 1.0003291374819574 0.8447123997369791 0.9560455568463644 0.01569613010331498 7.386247649328383e-05 4.822359493664905e-06 0.015229568745145564 0.005065904207503648 2.6170423896869003e-11 10.58218924279458 -0.1556167377449783 VAEIEHAEKEK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAEIEHAEKEK 11 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 35975700.0 6077700.0 5674000.0 24224000.0 True False 7867702.459377749 5358236.912153137 19815480.55922965 1.0 0.6810421390257959 2.518585401715464 22.907510968158594 -6.862127609963004 1.1748372958786244 0.825851573829842 2.6112959945272554 0.9561805399832958 0.16781912460495532 0.1446318673278199 0.378112519231411 0.11130588902012216 0.26049328896945007 1.3736382957237116e-07 6.862127609963004 1.7854444206974134 up VAELDK(ub)ITYER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAELDKITYER 11 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 13160100.0 1301700.0 2826900.0 9031500.0 True False 1260378.2460145548 3955695.9120887485 6665879.2108077025 1.0 3.138499037568337 5.28879265560628 20.265425328254526 -6.971057018911195 0.23155318245973663 0.14230047714830024 8.346546481580711 0.9999894939422966 0.005675179977484499 0.07596120329702011 0.0077920111897661 0.05462403682030562 0.21292813117488152 1.068914531264234e-07 6.971057018911195 8.204246004432411 VAELDK(ub)ITYER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAELDKITYER 11 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 99626600.0 4842600.0 20823000.0 73961000.0 True False 7346578.241481976 17106972.959158435 59342575.93174208 1.0 2.3285633660804193 8.077580334837801 22.808641022879055 -6.9430721577903185 0.6303342000941777 0.9372870634786369 9.778875334513932 0.9985392496313387 0.11739297995971443 0.08639261309164623 0.04843403860319094 0.11713329551246417 0.48850572211449633 1.1400603514212363e-07 6.9430721577903185 8.841588271035295 VAELDK(ub)ITYER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAELDKITYER 11 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 8980000.0 2078100.0 2738300.0 4163600.0 True False 2846429.7285408922 2617312.8516528234 3180243.43203367 1.0 0.9195072779802942 1.117274528208323 21.440722052844915 -6.796261366420424 1.4716495032074708 0.9553753999529899 1.1197430258097696 0.820842325733251 0.034370502009962056 0.22614924100853828 0.9673757718855447 0.01837883409338915 0.04283357480382433 1.5985956747338204e-07 6.796261366420424 0.16436762585677966 VAELDK(ub)ITYER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAELDKITYER 11 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 80140000.0 4842600.0 19846400.0 55451000.0 True False 6268841.161916968 18741930.39361229 45359486.975307226 1.0 2.989696167047426 7.23570526094437 22.579767344971504 -6.958756828077493 0.4526136379100126 0.8666742904426884 9.527788418402812 0.9997212774486429 0.043418199775378814 0.08014822781217029 0.022794970589091336 0.0569777677047459 0.35108344676001585 1.099621371535826e-07 6.958756828077493 8.661114127960124 VAELK(ub)GHTSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAELKGHTSR 10 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 6193430.0 879630.0 2326800.0 2987000.0 True False 851706.627135118 3255903.3741017007 2204615.091920791 1.0 3.822799154508835 2.5884676973061085 19.699997049883972 -9.721401320823333 6.863620188018057 0.9999999964923778 3.205633425907854 0.8097909745669923 0.5039137072701606 2.6923750108638077e-08 6.3556494242320615e-09 0.4879123490451287 0.16263744968171004 1.899322351785213e-10 9.721401320823333 2.2056334294154762 VAELK(ub)GHTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAELKGHTSR 10 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 1790320.0 709220.0 851100.0 230000.0 True False 971437.7999498452 813495.5877886709 175678.7369986898 1.0 0.8374139732164748 0.1808440406660725 19.88976209909285 -6.979826389280402 0.632926575502736 1.0057153413030815 4.948002518390099e-18 0.9986983185549189 0.012775812569213124 0.07974837248178165 0.046475580443751247 0.01296043666520123 0.05115770035862349 1.0475472249839393e-07 6.979826389280402 -1.0057153413030815 down VAELK(ub)GHTSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAELKGHTSR 10 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 4808230.0 879630.0 1368200.0 2560400.0 True False 731451.3192162593 1360829.235033564 3095767.802047974 1.0 1.8604508588372977 4.232363413282307 19.48040232531825 -6.953335843378106 0.5209353503814689 0.9599843682988803 5.23884965423166 0.999437739540679 0.03241079785808212 0.08217323604106982 0.0306278276485647 0.036662860389604784 0.19593956012479394 1.1134331738546612e-07 6.953335843378106 4.278865285932779 VAELVHFLLHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAELVHFLLHK 11 0 A0A075B7A9;P43362 A0A075B7A9 MAGEA9 Melanoma-associated antigen 9 0 7186400.0 3539500.0 1130900.0 2516000.0 False True 4640318.776566755 962174.1282136737 2255668.45517619 1.0 0.20735086845166273 0.4861020468178045 22.14579248708539 -10.37777218387105 5.849394447029453 1.0001497749340842 0.34672645764812193 0.8798525771399919 0.11379969203276802 0.00022232613870821536 2.3650102009510613e-05 0.11021088576922693 0.03672869267053647 4.1901330762229245e-11 10.37777218387105 -0.6534233172859623 VAELVHFLLHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAELVHFLLHK 11 0 A0A075B7A9;P43362 A0A075B7A9 MAGEA9 Melanoma-associated antigen 9 0 9053600.0 2986800.0 2296300.0 3770500.0 False True 2891985.668891662 3213224.565046308 2782892.937424618 1.0 1.1110790069294358 0.962277568440077 21.46362897241882 -6.706912545170511 1.806686193598052 1.068505180193127 0.9626650983964665 0.4502283582539429 0.04683145746423868 0.38130562174640337 2.4243171616862016 0.020645284753633555 0.05263666562942337 1.9637556827988007e-07 6.706912545170511 -0.10584008179666038 VAELVHFLLHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAELVHFLLHK 11 0 A0A075B7A9;P43362 A0A075B7A9 MAGEA9 Melanoma-associated antigen 9 0 9609800.0 3539500.0 2655400.0 3414900.0 False True 4848148.801390928 2538075.6477664625 2608370.952073153 1.0 0.5235143869838095 0.5380137984471134 22.209002548608282 -9.993742898015862 5.991353247575395 1.000000439085881 0.5307640927338828 0.9992844020997368 0.005919359942843293 3.4717345792978064e-08 5.8301495573763985e-09 0.005731400999881477 0.0019104652065381161 1.0145117981662099e-10 9.993742898015862 -0.4692363463519982 VAELVHFLLHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAELVHFLLHK 11 0 A0A075B7A9;P43362 A0A075B7A9 MAGEA9 Melanoma-associated antigen 9 0 6096300.0 2986800.0 1394400.0 1715100.0 False True 2483656.5376750734 1386888.0904332714 2073719.4802735827 1.0 0.558405749504931 0.8349461565304723 21.244034247853097 -10.505866710675372 5.855658572517077 1.0003876421647295 0.6966759530177019 0.6159922307610393 0.11289714841235834 0.0005720504057117537 4.827279593447224e-05 0.10944889219369344 0.03643739796961419 3.119846949438432e-11 10.505866710675372 -0.3037116891470276 VAEQVLQQK(ub)EHTINMEECR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAEQVLQQKEHTINMEECR 19 1 P80217;P80217-2 P80217 IFI35 Interferon-induced 35 kDa protein 1 57729500.0 9909100.0 21487400.0 26333000.0 True False 15032829.152246509 17652805.588177543 21128271.00783609 1.0 1.174283656748637 1.4054753628779635 23.841613211710424 -6.967219126657446 0.317670385185787 0.9674602195215117 1.6197302752973466 0.9999518509977264 0.001152386490106984 0.0772157873368749 0.01224582032370454 0.003538102712968237 0.020378553891619168 1.0784024685876598e-07 6.967219126657446 0.6522700557758349 VAEQVLQQK(ub)EHTINMEECR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAEQVLQQKEHTINMEECR 19 1 P80217;P80217-2 P80217 IFI35 Interferon-induced 35 kDa protein 1 68808800.0 9909100.0 19208800.0 39690900.0 True False 12827525.287562745 18139813.394107714 32467563.4630254 1.0 1.4141319535495778 2.531085516120959 23.612739533802873 -6.953815859359036 0.5152525147075445 0.9802994078658954 3.0143614416892466 0.9994677121114952 0.014918913574546592 0.08198871764387955 0.029893920187151948 0.0170318797833705 0.09222114666266758 1.1122032009176492e-07 6.953815859359036 2.0340620338233513 up VAETANEEEVK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAETANEEEVKK 12 1 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 21736730.0 5549320.0 8881210.0 7306200.0 True False 7275212.25969133 7556168.086685427 6550224.510019182 1.0 1.0386182309141339 0.9003482340042533 22.794557909652564 -6.832178465672521 1.3182922026896082 1.020605245949371 0.8964630207476355 0.9101354145793048 0.01746266872579861 0.17813918373468005 0.6047204733883427 0.010398553118817459 0.023927840485707924 1.4717076058210486e-07 6.832178465672521 -0.12414222520173557 VAETANEEEVK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAETANEEEVKK 12 1 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 16108670.0 646370.0 607800.0 14854500.0 True False 625851.3381550508 850497.7096351276 10963660.824552195 1.0 1.3589452602950607 17.517995338752502 19.2554604811522 -6.911690096597032 0.8841369507823803 0.5260284327712258 19.683643185189926 0.9915440978967274 0.7083780449355259 0.10331124641232202 0.13277997267828084 0.5848487579394142 1.6340138446650458 1.2254903714723026e-07 6.911690096597032 19.1576147524187 up VAETANEEEVK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAETANEEEVKK 12 1 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 80960800.0 1411800.0 17227900.0 62321100.0 True False 2141803.816405289 14153446.642802918 50003307.268691555 1.0 6.608190037945423 23.346352679777624 21.030394908393976 -6.95156659351238 0.5413746345652078 0.7557746878985063 29.973556076885462 0.9993185417360179 0.24780082169268194 0.0828627663161842 0.033406016953521134 0.2720411729312593 1.3864637585718234 1.1179783837330943e-07 6.95156659351238 29.217781388986957 VAETANEEEVK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAETANEEEVKK 12 1 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 22334960.0 5549320.0 6413210.0 10372430.0 True False 7601053.568734212 6129853.176550551 7922675.660901392 1.0 0.8064478326747727 1.0423128306173401 22.857767971175456 -6.688616962389934 1.8711311834047333 0.8785000122524509 1.0414889173150919 0.36405570117269737 0.08188178973723713 0.4196446786527855 2.8474398528873914 0.0350204622097415 0.0913617287238642 2.048250349374858e-07 6.688616962389934 0.16298890506264097 VAETANEEEVK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAETANEEEVKK 12 1 P61221;D6R9I9 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 53628500.0 1411800.0 1366500.0 50850200.0 True False 1827602.9307385238 1290453.07374996 41595985.36711275 1.0 0.7060905036021666 22.759859194526488 20.801521230486426 -6.903880209340273 0.9364057828479445 0.17812520602452542 25.26623623143023 0.9883999910533688 1.1123243322872767 0.10860540416950556 0.16174730604754414 0.8839729522164305 2.348134357175903 1.2477276252322015e-07 6.903880209340273 25.088111025405706 up VAEVLEGK(ub)GAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAEVLEGKGAGK 12 1 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 1 2442010.0 851680.0 759920.0 830410.0 True False 1166569.1117865886 726344.2216806099 634284.2608307911 1.0 0.6226328250438768 0.5437176884097259 20.153840349666613 -13.999999999994941 0.2199490255066394 3.276686898395842 0.5014851862545836 0.999497840691593 0.004461984681389339 12.998193627742982 0.14857206761299482 12.853037805432406 0.043688051391709996 1.000000000011649e-14 13.999999999994941 -2.7752017121412584 VAEVLEGK(ub)GAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAEVLEGKGAGK 12 1 Q9BTE6;C9J5N1;Q9BTE6-2;Q9BTE6-3 Q9BTE6 AARSD1;PTGES3L-AARSD1 Alanyl-tRNA editing protein Aarsd1 1 4834100.0 1154000.0 2492800.0 1187300.0 True False 959602.1308681646 2479370.7916179416 1435558.9405450565 1.0 2.583748734879134 1.4959939066061552 19.87207683568375 -10.509208449050927 5.460520030342881 0.9978273428749663 2.039871320741548 0.5492508940475751 0.4440740490862662 0.011761794497623811 0.0010571490685853866 0.4305474320112679 0.14332428304949882 3.095932982403712e-11 10.509208449050927 1.042043977866582 VAFHPARPFLLVASQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAFHPARPFLLVASQR 16 1 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 24088000.0 8420600.0 10759000.0 4908400.0 False True 11039488.14520641 9153799.138253536 4400525.852697455 1.0 0.8291869168072179 0.39861683755765986 23.396169946156284 -6.955284870084435 0.4974582260640551 1.008816247733095 0.20049685854679777 0.9995533830860396 0.005347413717875845 0.08143053601656473 0.027698302767631505 0.006301522985024039 0.035515450486661965 1.1084475043465292e-07 6.955284870084435 -0.8083193891862973 down VAFHPARPFLLVASQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAFHPARPFLLVASQR 16 1 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 24796200.0 9214000.0 4933200.0 10649000.0 False True 8921506.6134886 6903052.486298142 7859707.4368478395 1.0 0.7737541185993498 0.8809843199538288 23.0888559342082 -10.077461119323909 4.494756243015484 1.000012013755341 0.8273692192663794 0.7755703455905559 0.04377654642180213 60808516.76278142 0.09586003655559959 7752.057494736928 0.014985876223178722 8.366404935344596e-11 10.077461119323909 -0.17264279448896158 VAFHPARPFLLVASQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAFHPARPFLLVASQR 16 1 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 28412900.0 6113800.0 7529100.0 14770000.0 False True 9275081.5786504 6185473.279873201 11850703.026079023 1.0 0.6668915229932929 1.2776925923063847 23.14492854028638 -6.75863374366948 1.6178575391025183 0.806183579785701 1.279756650906162 0.685292513420532 0.14007888838894778 0.28520747789809126 1.471045289035531 0.06832859784136934 0.1644106723310657 1.7432764220468228e-07 6.75863374366948 0.473573071120461 VAFHPARPFLLVASQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAFHPARPFLLVASQR 16 1 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 30714200.0 8420600.0 9011600.0 13282000.0 False True 11533923.378158644 8613437.714623887 10145065.151376512 1.0 0.7467916538213554 0.8795849268938131 23.459380007679176 -10.208329624104543 5.1842794350431305 1.000014694796013 0.8131882903575064 0.725178755465924 0.05421262671720328 9.208497554738798e-06 1.4062269535310865e-06 0.0524952774688381 0.017497050035784896 6.189711053863362e-11 10.208329624104543 -0.1868264044385065 VAFHPARPFLLVASQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAFHPARPFLLVASQR 16 1 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 22258800.0 9214000.0 4986400.0 8058400.0 False True 7661849.249410108 4959537.273477091 9743374.18216817 1.0 0.6473029045643166 1.2716739608154417 22.869261209642477 -6.7534192004465545 1.6369455623115636 0.7934719628398853 1.2732663273707725 0.6636776152444598 0.14823832831930187 0.2941040865660049 1.5514901444260656 0.07150311748209286 0.1729884244451275 1.7643339844828577e-07 6.7534192004465545 0.4797943645308872 VAFHPARPFLLVASQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAFHPARPFLLVASQR 16 1 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 45300800.0 6113800.0 21286000.0 17901000.0 False True 7914434.621015136 20101415.388102178 14643201.679770876 1.0 2.539842244034343 1.8501892277799474 22.91605486237883 -10.441931917850386 5.598492387399693 0.9991025016959564 2.195015735907146 0.800134331507388 0.2815496648991141 0.003155941406636878 0.0003145892568267215 0.2727771613252533 0.09086976360704416 3.614665234771577e-11 10.441931917850386 1.1959132342111896 VAFSVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAFSVAR 7 0 P39023;G5E9G0;B5MCW2;H7C422 P39023 RPL3 60S ribosomal protein L3 0 66343000.0 21195000.0 17079000.0 28069000.0 False True 27786850.25267197 14530879.773420563 25164689.136860244 1.0 0.522940874596727 0.9056330209445175 24.727898972935417 -9.921867521458074 6.722428401961218 1.000000016153316 0.7142869477706189 0.4263390346443816 0.15623341452044598 3.7940476046359967e-08 6.035677797525596e-09 0.15127236215622117 0.0504241177132319 1.1971056444524892e-10 9.921867521458074 -0.28571306838269717 VAFSVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAFSVAR 7 0 P39023;G5E9G0;B5MCW2;H7C422 P39023 RPL3 60S ribosomal protein L3 0 32926900.0 13722000.0 3970900.0 15234000.0 False True 13286402.62104304 5556501.077969936 11243758.389796235 1.0 0.4182095964162289 0.8462605500143688 23.66344720273682 -9.77923385893133 6.1046914730607 1.0000000129768625 0.632235073214741 0.49602145639299344 0.17475107003993154 3.080978700435781e-08 6.195169063349118e-09 0.16920200104084324 0.056400665332745535 1.6625171768968735e-10 9.77923385893133 -0.36776493976212143 VAFSVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAFSVAR 7 0 P39023;G5E9G0;B5MCW2;H7C422 P39023 RPL3 60S ribosomal protein L3 0 59368100.0 13465000.0 37571000.0 8332100.0 False True 20427389.423358236 30866161.506437197 6685256.7829108415 1.0 1.511018410954778 0.327269267959733 24.284001506724916 -6.789338702328927 1.498707172684437 1.2858341826911444 0.3148459076512093 0.799329692384437 0.2171562102332287 0.2362927604207107 1.0484717478669627 0.11405005518093041 0.2671789450305268 1.6242814992389938e-07 6.789338702328927 -0.970988275039935 down VAFSVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAFSVAR 7 0 P39023;G5E9G0;B5MCW2;H7C422 P39023 RPL3 60S ribosomal protein L3 0 52880000.0 21195000.0 13866000.0 17819000.0 False True 29031364.273338262 13253354.27126978 13610519.193824586 1.0 0.4565184793413707 0.4688212054272687 24.79110903445831 -9.972815905704108 5.328456056052082 1.0000016597536217 0.46266984238283454 0.9996069829446649 0.005022566900078484 13808461.984743703 4.652785671880592 306.12242519119883 0.0017193582411966681 1.0645941963869738e-10 9.972815905704108 -0.5373318173707871 VAFSVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAFSVAR 7 0 P39023;G5E9G0;B5MCW2;H7C422 P39023 RPL3 60S ribosomal protein L3 0 36257100.0 13465000.0 14682000.0 8110100.0 False True 17430707.934830837 13864933.793484736 6634145.016653246 1.0 0.795431479049637 0.38060100837307903 24.055127828817366 -6.959773887572059 0.4386127128102131 1.0150489529815798 0.144847203532384 0.9997617103903521 0.003977696740247177 0.07978205202730372 0.02143087085521424 0.005460015700547809 0.034380452625737114 1.0970492185933488e-07 6.959773887572059 -0.8702017494491958 down VAFVLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAFVLGR 7 0 J3QSH9;J3KTM2;J3KRL7;O15534-4;O15534 J3QSH9 PER1 Period circadian protein homolog 1 0 20701900.0 5535300.0 4933600.0 10233000.0 False True 7256831.903921458 4197526.11102218 9174187.321867228 1.0 0.5784240515139829 1.2642138392250295 22.790908421396015 -6.740403823579276 1.685503061927444 0.7492791752170587 1.2646294024037077 0.6066521909038196 0.17712579286333177 0.3170762495452747 1.7689114560774613 0.08313479376180273 0.20389246488628604 1.8180096177350736e-07 6.740403823579276 0.515350227186649 VAFVLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAFVLGR 7 0 J3QSH9;J3KTM2;J3KRL7;O15534-4;O15534 J3QSH9 PER1 Period circadian protein homolog 1 0 19819500.0 6400400.0 2478100.0 10941000.0 False True 6197222.805401837 3467618.253120779 8075223.877035611 1.0 0.5595439057150267 1.3030391403705552 22.563190407001127 -6.746169155977059 1.6637653145141433 0.7398282674796063 1.3041213077727838 0.6324678874133737 0.18505842319623111 0.30675553476011796 1.6693812919670417 0.08790779040296007 0.21430330488851182 1.79403472132717e-07 6.746169155977059 0.5642930402931775 VAFVLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAFVLGR 7 0 J3QSH9;J3KTM2;J3KRL7;O15534-4;O15534 J3QSH9 PER1 Period circadian protein homolog 1 0 17562900.0 5535300.0 3637800.0 8389800.0 False True 7581849.995857959 3477069.9674040927 6408302.033354818 1.0 0.45860442626847686 0.8452161460403118 22.854118482918906 -10.221405491627424 5.704535073945797 1.0000125942267604 0.6519102861543933 0.5194304097060871 0.15783357367017592 2.5281964589122255e-05 3.4504903197672975e-06 0.15282722554759495 0.05094056685807833 6.006126961602834e-11 10.221405491627424 -0.3481023080723671 VAFVLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAFVLGR 7 0 J3QSH9;J3KTM2;J3KRL7;O15534-4;O15534 J3QSH9 PER1 Period circadian protein homolog 1 0 13170500.0 6400400.0 2260500.0 4509600.0 False True 5322216.1857960215 2248322.2378258826 5452536.509965454 1.0 0.4224409831051631 1.0244861012067177 22.343595682435403 -10.964951391283021 12.820315290808795 1.0982693721688723 0.7234635421559407 0.21954885306039118 0.24578389024707417 0.09975722637150809 0.00027271934328909164 0.03438834664742973 0.07932640947441583 1.0840482400971322e-11 10.964951391283021 -0.37480583001293166 VAGALVQNTEK(ub)GPNAEQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAGALVQNTEKGPNAEQLR 19 1 Q9UPN7 Q9UPN7 PPP6R1 Serine/threonine-protein phosphatase 6 regulatory subunit 1 1 22011200.0 3025400.0 3176800.0 15809000.0 True False 2929360.3330202317 4445312.806793149 11668148.640165977 1.0 1.5175029021472202 3.983172882025023 21.48215423563374 -6.940886699695908 0.651261383378465 0.972691166412424 4.665798059398781 0.9982777592848745 0.05401482834643732 0.0873644199064592 0.0527847645626292 0.0529396074995525 0.21139990696825328 1.145811825960842e-07 6.940886699695908 3.6931068929863566 up VAGALVQNTEK(ub)GPNAEQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAGALVQNTEKGPNAEQLR 19 1 Q9UPN7 Q9UPN7 PPP6R1 Serine/threonine-protein phosphatase 6 regulatory subunit 1 1 67799700.0 5332700.0 16850000.0 45617000.0 True False 8090095.772591361 13842985.850349095 36600779.95535862 1.0 1.7111028397522925 4.524146683078749 22.947725351067778 -6.945129460365306 0.6099782135384093 0.9688836223568789 5.41285498062719 0.9987614931920342 0.053550199551144435 0.08550248250437328 0.04452502640744728 0.054433664643625486 0.23720128678003763 1.1346725267408333e-07 6.945129460365306 4.4439713582703115 VAGALVQNTEK(ub)GPNAEQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAGALVQNTEKGPNAEQLR 19 1 Q9UPN7 Q9UPN7 PPP6R1 Serine/threonine-protein phosphatase 6 regulatory subunit 1 1 13015000.0 3025400.0 3545700.0 6443900.0 True False 2515754.1479450124 3526598.6103336546 7791289.696772749 1.0 1.401805742112896 3.0969996424877384 21.262559511068016 -6.94365190193245 0.6246646660334382 0.981491769482888 3.607843587384235 0.9986041793752525 0.03395174539291732 0.08613938361455103 0.04731432291130314 0.034047935732928206 0.1437212832620992 1.1385394885409134e-07 6.94365190193245 2.626351817901347 up VAGALVQNTEK(ub)GPNAEQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAGALVQNTEKGPNAEQLR 19 1 Q9UPN7 Q9UPN7 PPP6R1 Serine/threonine-protein phosphatase 6 regulatory subunit 1 1 44946700.0 5332700.0 18129000.0 21485000.0 True False 6903285.273232275 17120105.21332824 17574950.454716355 1.0 2.4799938776559087 2.5458821067215385 22.718851673160227 -10.677391498631412 0.5799516835121766 9.439317074110893e-15 2.538936895826585 0.9998395954631516 0.009039236870972436 2.198689101145575 0.2827211591332401 3.1528624344864964 0.011760835240826372 2.1018828244797945e-11 10.677391498631412 2.5389368958265757 VAGCSVHK(ub)GYAFVQYSNER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAGCSVHKGYAFVQYSNER 19 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2 Q5QPL9 RALY RNA-binding protein Raly 1 14292800.0 4090800.0 5631100.0 4570900.0 True False 5363078.415363558 4790961.829855882 4097947.1151688546 1.0 0.8933230989372187 0.7641035237205382 22.3546299169667 -6.9685659446500114 0.2904070833435538 1.0251260167282892 0.6283060088516645 0.9999689304015323 0.0005375868049594102 0.07677085723466727 0.010687410044340682 0.0022526040830651733 0.011712695802620202 1.0750633469740913e-07 6.9685659446500114 -0.39682000787662464 VAGCSVHK(ub)GYAFVQYSNER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAGCSVHKGYAFVQYSNER 19 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2 Q5QPL9 RALY RNA-binding protein Raly 1 12062900.0 4090800.0 4293500.0 3678600.0 True False 5603279.309713247 4103798.9732941575 2809790.4431451303 1.0 0.7323923628401406 0.5014546460809793 22.417839978489592 -6.97284534527592 0.17752726973475502 1.184485731131033 0.043131637067477864 0.9999969142699149 0.0003578019740444394 0.0753898332642707 0.005583156123404545 0.009090756784473608 0.02611415610504633 1.0645220330591843e-07 6.97284534527592 -1.1413540940635551 VAGCSVHK(ub)GYAFVQYSNER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAGCSVHKGYAFVQYSNER 19 1 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2 Q5QPL9 RALY RNA-binding protein Raly 1 14730200.0 2715500.0 4089100.0 7925600.0 True False 3515268.280507479 3861537.990392214 6483222.123523384 1.0 1.0985044901991794 1.8443036508688433 21.745203367352534 -6.931135738758925 0.7374079081396256 0.9891234869296426 2.0019379819414125 0.9967568699828772 0.021466281472772786 0.09205212237297568 0.07482173214328489 0.019690713297186545 0.06706531264576239 1.171829053084878e-07 6.931135738758925 1.01281449501177 VAGFNPALQLILTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAGFNPALQLILTR 14 0 Q9H496 Q9H496 TOR1AIP2 Torsin-1A-interacting protein 2, isoform IFRG15 0 2897170.0 656210.0 1417100.0 823860.0 False True 860297.6647466789 1205674.2038125372 738614.8702231534 1.0 1.4014616721847746 0.8585573348506579 19.71447639605602 -6.708630241214625 1.799983723046505 1.2471610629418861 0.8598809821846459 0.4585391642205894 0.16921172146588467 0.37788912937384367 2.385757390401803 0.07483230253834945 0.19043306980295782 1.9560040910092822e-07 6.708630241214625 -0.3872800807572402 VAGFNPALQLILTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAGFNPALQLILTR 14 0 Q9H496 Q9H496 TOR1AIP2 Torsin-1A-interacting protein 2, isoform IFRG15 0 8681300.0 3478300.0 2360900.0 2842100.0 False True 3367883.2704251558 3303619.6819308526 2097668.7488276097 1.0 0.980918700758239 0.6228448495374377 21.68341070532434 -6.917921255034616 0.8399980496298908 1.0085080271917934 0.5677752928038725 0.9935837597919606 0.013895205814615117 0.09941048113354287 0.11206548710419507 0.011842177219785149 0.03479778076694612 1.2080328521230722e-07 6.917921255034616 -0.44073273438792093 VAGFNPALQLILTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAGFNPALQLILTR 14 0 Q9H496 Q9H496 TOR1AIP2 Torsin-1A-interacting protein 2, isoform IFRG15 0 40848000.0 11818000.0 14008000.0 15022000.0 False True 17928770.011529744 11508162.954996452 12052895.1156235 1.0 0.6418824575024227 0.672265588095137 24.095773180910072 -10.084191246146458 5.320225606167779 1.0000046014114383 0.6570740227984537 0.9941470306731656 0.012403861124558206 6.76998840993324e-07 1.1654263072372755e-07 0.012010148008731045 0.004003328963508706 8.237752770148672e-11 10.084191246146458 -0.3429305786129846 VAGFNPALQLILTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAGFNPALQLILTR 14 0 Q9H496 Q9H496 TOR1AIP2 Torsin-1A-interacting protein 2, isoform IFRG15 0 7178610.0 656210.0 1386200.0 5136200.0 False True 898828.5704084589 1324953.1004495993 3923135.3433594317 1.0 1.4740887685039814 4.364720339916012 19.777686457578913 -6.935496533139202 0.7002143245492158 0.9636895239189499 5.05073864298585 0.9975123633588378 0.0741684126819829 0.0898828552882527 0.06442569698736667 0.0699357329775625 0.2541157202025184 1.1601214770615223e-07 6.935496533139202 4.087049119066901 up VAGFNPALQLILTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAGFNPALQLILTR 14 0 Q9H496 Q9H496 TOR1AIP2 Torsin-1A-interacting protein 2, isoform IFRG15 0 7610100.0 3478300.0 1549600.0 2582200.0 False True 2892360.5648169275 1541251.9972284841 3122126.0812561624 1.0 0.5328699388231487 1.0794387529805702 21.463815980758618 -6.680357070142834 1.9002698419394548 0.7045458919799877 1.0773829385709652 0.3259421347655066 0.19796365902269303 0.4377135813660189 3.0561388456938134 0.08357629538602891 0.22035426654698942 2.087579050168448e-07 6.680357070142834 0.3728370465909775 VAGFNPALQLILTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAGFNPALQLILTR 14 0 Q9H496 Q9H496 TOR1AIP2 Torsin-1A-interacting protein 2, isoform IFRG15 0 33919000.0 11818000.0 10832000.0 11269000.0 False True 15298633.967607213 10229189.67790674 9218157.629704379 1.0 0.668634186527089 0.6025477600956124 23.86689950300252 -13.999999999999984 0.2266582244040394 3.0599808011996625 0.5693769688513136 0.9995054159403083 0.003867173991343261 13.189377472692337 0.1507680861260133 12.204756139240494 0.035032278936475376 1.0000000000000368e-14 13.999999999999984 -2.490603832348349 VAGGAAPSKPASAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAGGAAPSKPASAK 14 1 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 11663200.0 4460300.0 1659200.0 5543700.0 False True 4318710.217944788 2321727.2126136967 4091638.6625648793 1.0 0.5375973601948624 0.9474214420693481 22.042169085415377 -10.281051612716048 8.172382608764263 1.000000342957323 0.7425094011321053 0.3448380644682034 0.167309980816181 1.0454304367469082e-06 9.21583426899224e-08 0.16199740717348493 0.05399906411294595 5.2353821420895857e-11 10.281051612716048 -0.2574909418252177 VAGHSLGYGFVNYVTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAGHSLGYGFVNYVTAK 17 0 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 0 37230000.0 14949000.0 15399000.0 6882000.0 False True 19598283.76632191 13101529.224831866 6169916.65680546 1.0 0.6685039047830199 0.31481923266199313 24.224223986397647 -7.274293286824068 0.29491864436715315 1.079202473485828 1.992358719045803e-11 0.9998896500650168 0.0029389394290648637 0.10092441173382095 0.019129622397828748 0.012574981990348741 0.046419909478136054 5.317490383588327e-08 7.274293286824068 -1.0792024734659045 down VAGHSLGYGFVNYVTAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAGHSLGYGFVNYVTAK 17 0 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 0 46195400.0 15266000.0 8099400.0 22830000.0 False True 14781389.18618591 11333532.657813016 16850138.11468084 1.0 0.766743403820588 1.1399563263261008 23.817278527595477 -6.73772542343115 1.6951856670517254 0.8608493669468831 1.140062141178471 0.594649564550302 0.09801070410871793 0.32193148747410033 1.8156107111065047 0.04575747123528785 0.11255929190273598 1.8292563721975421e-07 6.73772542343115 0.27921277423158797 VAGHSLGYGFVNYVTAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAGHSLGYGFVNYVTAK 17 0 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 0 43322000.0 11241000.0 20623000.0 11458000.0 False True 17053418.827179365 16942664.52176555 9193321.277780196 1.0 0.9935054485827031 0.5390896318765175 24.023557660386153 -6.910012342702834 0.8956524086273575 1.0140641176793066 0.4803488396135351 0.9909261866668622 0.020552626544614466 0.1044098124414279 0.1387235984419445 0.016827737031886027 0.04645604300484644 1.2302338069187528e-07 6.910012342702834 -0.5337152780657715 VAGHSLGYGFVNYVTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAGHSLGYGFVNYVTAK 17 0 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 0 47004000.0 14949000.0 13837000.0 18218000.0 False True 20476049.28153495 13225635.587159961 13915283.611487512 1.0 0.6459075872163814 0.6795883043725697 24.287434047920538 -10.467763313929748 5.631634276553516 1.0003393065466801 0.662747945794475 0.9925753110892976 0.013750095200612478 5.863573296635642e-05 5.541576734437365e-06 0.013326607516949694 0.0044378241433946424 3.4059375926020635e-11 10.467763313929748 -0.3375913607522051 VAGHSLGYGFVNYVTAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAGHSLGYGFVNYVTAK 17 0 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 0 35135100.0 15266000.0 10399000.0 9470100.0 False True 12694355.398469144 10342978.522960115 11450254.125204865 1.0 0.814769887741398 0.9019957111477823 23.597683803029753 -10.049269053222561 4.333842111952861 1.0000104946898225 0.8583827994238132 0.7784982891065986 0.035609793366238054 49715913.80103085 65208603.133618444 6792.82817437541 0.013031853765361876 8.9275223635171e-11 10.049269053222561 -0.14162769526600927 VAGHSLGYGFVNYVTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAGHSLGYGFVNYVTAK 17 0 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 0 49127000.0 11241000.0 26748000.0 11138000.0 False True 14551696.093236808 25259450.28661832 9110998.285530876 1.0 1.7358423461274837 0.6261124632588634 23.794683982478603 -6.7279444485083255 1.731039543655913 1.4438369665696114 0.6270518199347581 0.5496258216446348 0.3093821853422979 0.3400771354279367 1.9954939124816278 0.1416992778270302 0.3523961777104657 1.8709214384324749e-07 6.7279444485083255 -0.8167851466348532 VAGHSLGYGFVNYVTAK(ub)DAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAGHSLGYGFVNYVTAKDAER 21 1 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 1 42215500.0 8930700.0 9278800.0 24006000.0 True False 13548524.821625385 7622925.64440471 19261203.577796414 1.0 0.5626387923973413 1.421645812469028 23.69163244210925 -6.768283818425406 1.5810408482516436 0.7486013851148318 1.4261687552177176 0.7240049753196875 0.184245096937909 0.269182522178933 1.3276785161370601 0.09187060362775025 0.21903470013021267 1.7049678009761215e-07 6.768283818425406 0.6775673701028858 VAGHSLGYGFVNYVTAK(ub)DAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAGHSLGYGFVNYVTAKDAER 21 1 Q15717;Q15717-2;M0QZR9 Q15717 ELAVL1 ELAV-like protein 1 1 50351500.0 8930700.0 8142800.0 33278000.0 True False 11560967.200415455 7689646.021903519 27221745.46111476 1.0 0.6651386418280976 2.354625265275082 23.4627587642017 -6.8552004277115675 1.209613854402848 0.8201463412375171 2.429297704501099 0.9475453444983611 0.16728597744200366 0.15183441683311988 0.4248866407463467 0.10804902943451275 0.2510291108781874 1.395724083138003e-07 6.8552004277115675 1.6091513632635817 up VAGILTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAGILTVK 8 0 Q99798;A2A274 Q99798 ACO2 Aconitate hydratase, mitochondrial 0 18824400.0 6095300.0 7000500.0 5728600.0 False True 7990997.326969171 5956052.687735268 5135859.424611415 1.0 0.7453453485253864 0.6427056867205018 22.92994414117339 -13.999999999999998 0.12519710955764163 2.2105677029534907 0.48979684788786226 0.9996678684648508 0.00273732883951543 11.946790082299243 0.10952981654295732 3.575904429540722 0.13579128024907544 1.0000000000000041e-14 13.999999999999998 -1.7207708550656284 VAGILTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAGILTVK 8 0 Q99798;A2A274 Q99798 ACO2 Aconitate hydratase, mitochondrial 0 13547400.0 4601200.0 2290800.0 6655400.0 False True 4455137.424569539 3205528.3863641806 4912151.082279757 1.0 0.7195127963249984 1.102581270600059 22.08703850358251 -6.710473421978949 1.793968410758176 0.8276424389152642 1.1016765959624375 0.46717361168247173 0.11818709098271049 0.37410962498878797 2.347395579846168 0.052426494017609716 0.13308903248040416 1.9477202431806617e-07 6.710473421978949 0.27403415704717327 VAGILTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAGILTVK 8 0 Q99798;A2A274 Q99798 ACO2 Aconitate hydratase, mitochondrial 0 15804900.0 6095300.0 3864000.0 5845600.0 False True 8348897.1292889295 3693275.7034607264 4464989.673911052 1.0 0.442366895443504 0.5347999388143536 22.99315420269628 -10.817092658833753 7.320345717326907 1.0234331047803427 0.48858341712892944 0.9760858911517388 0.03773563193852147 0.013056284133671315 0.00032622605962739166 0.03305536397436784 0.012179122838042187 1.5237276244368257e-11 10.817092658833753 -0.5348496876514133 VAGILTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAGILTVK 8 0 Q99798;A2A274 Q99798 ACO2 Aconitate hydratase, mitochondrial 0 9715800.0 4601200.0 3127400.0 1987200.0 False True 3826101.6677214867 3110552.075459701 2402714.33222533 1.0 0.8129820756467487 0.6279797404485047 21.867443779016785 -6.971259007675992 0.2261075992008077 1.079000504530187 0.35669977594340846 0.999990604483174 0.0004655003668470843 0.07589627333941003 0.007552034240976256 0.004892951304887105 0.018516167037137776 1.0684174986436402e-07 6.971259007675992 -0.7223007285867784 VAGISLAYSSVQDVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAGISLAYSSVQDVQK 16 0 Q9NX46 Q9NX46 ADPRHL2 Poly(ADP-ribose) glycohydrolase ARH3 0 7334500.0 2376500.0 2211700.0 2746300.0 False True 3115614.5140587375 1881722.9811390752 2462139.220369782 1.0 0.6039652763999159 0.7902579761583959 21.571085313295296 -10.056792441230177 4.836632592182024 1.0000083048944692 0.697111626275112 0.7789869513015987 0.07605367621623739 19804160.73507581 41178716.88451565 1088.991469114869 0.026035200259423814 8.774200590661618e-11 10.056792441230177 -0.3028966786193572 VAGISLAYSSVQDVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAGISLAYSSVQDVQK 16 0 Q9NX46 Q9NX46 ADPRHL2 Poly(ADP-ribose) glycohydrolase ARH3 0 11018800.0 3259300.0 2034100.0 5725400.0 False True 3155835.3055506228 2846326.7376913647 4225745.981681713 1.0 0.9019249935778079 1.3390261444408345 21.58959048631521 -6.847786079019057 1.245716863207815 0.9477468760504563 1.3557688353997754 0.9370262029490696 0.046993457231255295 0.15990583775644115 0.4786265398303634 0.029535210874406723 0.06825700695962494 1.4197566808218256e-07 6.847786079019057 0.4080219593493192 VAGISLAYSSVQDVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAGISLAYSSVQDVQK 16 0 Q9NX46 Q9NX46 ADPRHL2 Poly(ADP-ribose) glycohydrolase ARH3 0 8984900.0 2376500.0 2220400.0 4388000.0 False True 3255156.2724976833 2122295.3861190993 3351644.773696743 1.0 0.6519795697828851 1.0296417416313546 21.634295374818187 -6.664490517030761 1.9570556055245978 0.7768143919827055 1.0280791456449345 0.2548151134988107 0.14802213585622287 0.47389282913529923 3.4937299784140903 0.061009435188337 0.1641729566587815 2.165257157925794e-07 6.664490517030761 0.251264753662229 VAGISLAYSSVQDVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAGISLAYSSVQDVQK 16 0 Q9NX46 Q9NX46 ADPRHL2 Poly(ADP-ribose) glycohydrolase ARH3 0 8057300.0 3259300.0 1727000.0 3071000.0 False True 2710252.3614719342 1717696.3082173376 3713131.901300318 1.0 0.6337772572899666 1.370031792642262 21.369995761749486 -6.771447547425114 1.5687945265649865 0.7903334134490131 1.3744132156466782 0.7361082877215928 0.1544070659445811 0.26409518866472126 1.2829156308026373 0.07756897367138921 0.18441115087939736 1.6925926575379307e-07 6.771447547425114 0.5840798021976651 VAGPNGYAILLAVPGSSDSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAGPNGYAILLAVPGSSDSR 20 0 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 0 4743600.0 1150900.0 1872300.0 1720400.0 False True 1508841.0453314541 1592960.1381682374 1542389.5112420972 1.0 1.0557507983342966 1.0222345925798124 20.525009396930933 -10.304923520269721 4.964620142747986 0.9999861900354013 1.0389926954570712 0.643450588860099 0.013682933702160652 2.092241559991948e-06 2.929559587696073e-07 0.013253135638250091 0.0044161478629691645 4.955374478046749e-11 10.304923520269721 0.039006505421669835 VAGPNGYAILLAVPGSSDSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAGPNGYAILLAVPGSSDSR 20 0 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 0 5930630.0 1611700.0 815330.0 3503600.0 False True 1560537.4656999777 1140895.5208897807 2585902.054252991 1.0 0.7310914002170611 1.6570586167202892 20.573611563512227 -6.82899668847582 1.3323113898583117 0.8562064929273261 1.681481531538047 0.9038627225308418 0.12059408437303079 0.18205620080631868 0.632357357885686 0.07107439399174716 0.16357626831420094 1.48252938948761e-07 6.82899668847582 0.8252750386107208 VAGPNGYAILLAVPGSSDSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAGPNGYAILLAVPGSSDSR 20 0 A0A494C001;A0A499FJY3;A0A087WWP4;Q96T37-4;Q96T37-2;Q96T37-3;Q96T37 A0A494C001 RBM15 Putative RNA-binding protein 15 0 4379000.0 1150900.0 1768900.0 1459200.0 False True 1576418.8319030437 1690744.149029938 1114567.0131673396 1.0 1.0725221716546494 0.7070246755564578 20.588219458453825 -6.855147192370986 1.2099806328145601 1.0389450257115451 0.6908952292055976 0.9474655761421205 0.036214732276138584 0.15188736309481188 0.4253375209125174 0.023385241796356017 0.054324557866083846 1.3958951799493254e-07 6.855147192370986 -0.3480497965059475 VAGQDGSVVQFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAGQDGSVVQFK 12 0 A8MUA9;A8MU27;P55854;P55854-2;Q6EEV6;P61956-2;P61956 A8MUA9;P61956-2 SUMO3;SUMO4;SUMO2 Small ubiquitin-related modifier 3;Small ubiquitin-related modifier 4;Small ubiquitin-related modifier 2 0 52695600.0 3287600.0 27594000.0 21814000.0 False True 4310075.437163692 23477082.760569546 19556896.53466352 1.0 5.447023631683575 4.537483582313636 22.03928168965236 -10.418047210692041 5.64581374683936 0.9979316641287889 4.9922536069986165 0.9625300618888212 0.37131817026373143 0.009665032612459021 0.0009962412780161244 0.3594509052635549 0.11984242413129825 3.8190275321999075e-11 10.418047210692041 3.994321942869828 VAGQDGSVVQFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAGQDGSVVQFK 12 0 A8MUA9;A8MU27;P55854;P55854-2;Q6EEV6;P61956-2;P61956 A8MUA9;P61956-2 SUMO3;SUMO4;SUMO2 Small ubiquitin-related modifier 3;Small ubiquitin-related modifier 4;Small ubiquitin-related modifier 2 0 38769400.0 14799000.0 3163400.0 20807000.0 False True 14329213.845563035 4426562.116913074 15357022.503379948 1.0 0.30891870025959134 1.0717281959006544 23.77245612431964 -6.668056190648879 1.943565284375538 0.5581859437009192 1.0686763525728418 0.27087487441080893 0.29368137104494607 0.46552123738418855 3.388085557050066 0.12170926866724509 0.32608600066053267 2.1475525977451402e-07 6.668056190648879 0.5104904088719225 VAGQDGSVVQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAGQDGSVVQFK 12 0 A8MUA9;A8MU27;P55854;P55854-2;Q6EEV6;P61956-2;P61956 A8MUA9;P61956-2 SUMO3;SUMO4;SUMO2 Small ubiquitin-related modifier 3;Small ubiquitin-related modifier 4;Small ubiquitin-related modifier 2 0 56627600.0 3287600.0 28652000.0 24688000.0 False True 4503114.564049398 27386059.900506403 18857202.865320243 1.0 6.081581872054274 4.187591187634148 22.10249175117525 -9.678303729962787 8.15399493628823 0.9999999993311196 5.134586529844221 0.8640195865107719 0.7732184590690333 0.0 0.0 0.7486655481606235 0.24955518457953874 2.097472473639896e-10 9.678303729962787 4.134586530513101 VAGQDGSVVQFK(ub)IK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAGQDGSVVQFKIK 14 1 A8MUA9;A8MU27;P55854;P55854-2;Q6EEV6;P61956-2;P61956 A8MUA9;P61956-2 SUMO3;SUMO4;SUMO2 Small ubiquitin-related modifier 3;Small ubiquitin-related modifier 4;Small ubiquitin-related modifier 2 1 28671100.0 8836300.0 9650800.0 10184000.0 True False 11584474.870850917 8210938.258523761 9130257.371826032 1.0 0.7087881280820321 0.7881459862112321 23.465689311919654 -9.932288143220568 6.399444946266923 1.0000000369684827 0.74846705714662 0.9305323087480112 0.032397709916163926 1.7083525743415695e-08 2.8486723030583735e-09 0.03136895241444943 0.010456315913373643 1.1687237155971963e-10 9.932288143220568 -0.25153297982186273 VAGQDGSVVQFK(ub)IK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAGQDGSVVQFKIK 14 1 A8MUA9;A8MU27;P55854;P55854-2;Q6EEV6;P61956-2;P61956 A8MUA9;P61956-2 SUMO3;SUMO4;SUMO2 Small ubiquitin-related modifier 3;Small ubiquitin-related modifier 4;Small ubiquitin-related modifier 2 1 71343000.0 11614000.0 12822000.0 46907000.0 True False 11245319.927182198 17941891.465846695 34620649.52016353 1.0 1.5954985346817514 3.078671815861678 23.422821370306682 -6.955542375747932 0.49427419648048326 0.9687643077490475 3.7687565159869894 0.9995674733314858 0.01817736517155153 0.08133369808963828 0.02732123792677876 0.021554129915040368 0.12233135736828384 1.1077904688132618e-07 6.955542375747932 2.799992208237942 VAGQDGSVVQFK(ub)IK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAGQDGSVVQFKIK 14 1 A8MUA9;A8MU27;P55854;P55854-2;Q6EEV6;P61956-2;P61956 A8MUA9;P61956-2 SUMO3;SUMO4;SUMO2 Small ubiquitin-related modifier 3;Small ubiquitin-related modifier 4;Small ubiquitin-related modifier 2 1 56245000.0 11614000.0 17711000.0 26920000.0 True False 9657555.587437503 17615587.327641767 32548847.535983227 1.0 1.8240213238385115 3.3702987511997957 23.20322664574096 -6.961272022586931 0.4171199452914142 0.9294952766086905 4.322879655848492 0.9998145046463308 0.013381742134149938 0.0792498254007124 0.019475253198120365 0.019968716691212564 0.1288208923361272 1.0932713756103495e-07 6.961272022586931 3.393384379239802 VAGSGK(ub)PPIFEVDPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAGSGKPPIFEVDPR 15 1 Q6Q0C0;Q6Q0C0-2 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 27596100.0 5687300.0 6848800.0 15060000.0 True False 5506759.77457062 9583561.556020182 11115334.209684338 1.0 1.7403267889541165 2.018489032518408 22.392772243439452 -10.565712578396818 0.20709657210465526 1.3322931544827349e-18 2.2336483004645 0.999347726142538 0.01097768571811785 2.32095290272796 0.1065202499898185 1.3462178388797241 0.16330461046306535 2.7182376378690582e-11 10.565712578396818 2.2336483004645 VAGSGK(ub)PPIFEVDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAGSGKPPIFEVDPR 15 1 Q6Q0C0;Q6Q0C0-2 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 42628500.0 6496500.0 21138000.0 14994000.0 True False 9855665.45776807 17365758.748052184 12030429.327896344 1.0 1.7620077327568768 1.2206612916649033 23.23252185512461 -10.096132743819105 5.784779511914048 0.9999970980349262 1.4913345122109325 0.5234362009087501 0.2210037591246447 8.271628013199728e-06 1.2931584695285574e-06 0.21398723520488347 0.07132865654489348 8.014330647740513e-11 10.096132743819105 0.4913374141760063 VAGSGK(ub)PPIFEVDPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAGSGKPPIFEVDPR 15 1 Q6Q0C0;Q6Q0C0-2 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 20698600.0 5687300.0 6778500.0 8232800.0 True False 4729241.940109625 6741982.875073097 9954240.41583368 1.0 1.42559483326345 2.1048279072825227 22.17317751887373 -6.964206521854187 0.3714244800745532 0.948602744226462 2.6055158575179775 0.999895834757009 0.004643674625497377 0.07823132910145827 0.0158161090523847 0.008933885796416453 0.057643021994002265 1.0859091139581134e-07 6.964206521854187 1.6569131132915156 up VAGSGK(ub)PPIFEVDPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAGSGKPPIFEVDPR 15 1 Q6Q0C0;Q6Q0C0-2 Q6Q0C0 TRAF7 E3 ubiquitin-protein ligase TRAF7 1 35811500.0 6496500.0 19285000.0 10030000.0 True False 8409847.315159952 18211772.797122546 8204642.916490797 1.0 2.165529541100374 0.9755995096011737 23.00364817721706 -6.650892246424116 2.005167092677926 1.7557697010442324 0.9805822427353119 0.19775766702329367 0.4973499580515995 0.5063416203560641 3.903217321313514 0.20107818873436634 0.5509669747274498 2.2341264671594502e-07 6.650892246424116 -0.7751874583089204 VAGVLGFAATHNLYSMNDCAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAGVLGFAATHNLYSMNDCAQK 22 0 E9PS17;E9PK59;Q96KG9-5;Q96KG9-3;Q96KG9-4;Q96KG9-6;Q96KG9-2;Q96KG9;H0YCI6;A0A0A0MQX4;E9PPN3 E9PS17 SCYL1 N-terminal kinase-like protein 0 5642600.0 1535300.0 2383100.0 1724200.0 False True 2012793.1678663506 2027550.7692510432 1545796.323694272 1.0 1.007331901568573 0.767985677004699 20.940767499643847 -6.8998345267242565 0.9623295065241457 1.0099963697499688 0.7429479451064172 0.9864833418924572 0.012921387725417715 0.1115266405313698 0.1781146109098454 0.010073772688111384 0.026188085314680823 1.2594051742869076e-07 6.8998345267242565 -0.2670484246435516 VAGVLGFAATHNLYSMNDCAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAGVLGFAATHNLYSMNDCAQK 22 0 E9PS17;E9PK59;Q96KG9-5;Q96KG9-3;Q96KG9-4;Q96KG9-6;Q96KG9-2;Q96KG9;H0YCI6;A0A0A0MQX4;E9PPN3 E9PS17 SCYL1 N-terminal kinase-like protein 0 6460100.0 1535300.0 2295400.0 2629400.0 False True 2102941.899922447 2193981.638127266 2008389.874192848 1.0 1.0432916088685933 0.9550382130228678 21.00397756116674 -6.7733377552393845 1.561849982380243 1.0247250875389555 0.9544800386271096 0.7431003344633452 0.01826263652164677 0.26106762954945273 1.2572908680066053 0.00921451109036566 0.021866343382268838 1.6852418858423592e-07 6.7733377552393845 -0.07024504891184591 VAHALAEGLGVIACIGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAHALAEGLGVIACIGEK 18 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 0 32824100.0 20045000.0 7238400.0 5540700.0 False True 19408682.44707828 10128730.867757335 4089424.452562949 1.0 0.5218659687681212 0.21070077599103373 24.210198848642126 -8.340446018775088 0.2716655952195903 1.1885062114952558 1.9005354277538806e-11 0.9992223279238587 0.009052725805799265 0.11109430397153838 0.06598353004099845 0.10387837584490521 0.10213072098641635 4.566190027567717e-09 8.340446018775088 -1.1885062114762504 down VAHALAEGLGVIACIGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAHALAEGLGVIACIGEK 18 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 0 165498000.0 25802000.0 96386000.0 43310000.0 False True 39143520.37887035 79185165.23274472 34749759.51655263 1.0 2.0229443970882297 0.8877525368237069 25.2222701750242 -6.6693394100404575 1.9401196838784704 1.6533320396356777 0.8923964808681897 0.2759428025264449 0.4345944715757776 0.46264055471251986 3.3567615459253 0.1803935577727758 0.48231076910050574 2.1412165424277463e-07 6.6693394100404575 -0.760935558767488 VAHALAEGLGVIACIGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAHALAEGLGVIACIGEK 18 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 0 22443200.0 4769700.0 4285500.0 13388000.0 False True 6533186.986295895 4096152.4397466164 10226030.134515043 1.0 0.6269761524258779 1.5652437556073795 22.639355501018123 -6.798828184043557 1.4607134824406864 0.7938805810758311 1.5778216551333628 0.828714393369081 0.15963510290349076 0.22243133238854254 0.9370945199097378 0.08598019135466252 0.20010078369169615 1.5891753351614603e-07 6.798828184043557 0.7839410740575317 VAHALAEGLGVIACIGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAHALAEGLGVIACIGEK 18 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 0 30874000.0 20045000.0 3121900.0 7707100.0 False True 16668305.644066188 3105081.705051371 9318618.976395857 1.0 0.1862865831331069 0.5590621611689264 23.990604124076402 -10.672784009482005 6.528226834385967 1.0045851423148624 0.3726743721998791 0.7906189671732087 0.15218499245980166 0.01018174858970045 0.0005103420566421869 0.14772640266715112 0.049117495111626094 2.1243006916983562e-11 10.672784009482005 -0.6319107701149833 VAHALAEGLGVIACIGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAHALAEGLGVIACIGEK 18 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 0 91740000.0 25802000.0 36733000.0 29205000.0 False True 33401197.633457504 34688776.25909787 23889989.668605603 1.0 1.0385488759945127 0.7152435050614874 24.99339649711665 -6.877138561194145 1.0956887451914155 1.0230944696513589 0.6935569759637173 0.9713005937112947 0.024425896088645777 0.13019230405054352 0.2878909992199759 0.017215121549537537 0.04134242277905464 1.326971021486933e-07 6.877138561194145 -0.3295374936876415 VAHFLEK(ub)QGFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAHFLEKQGFK 11 1 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 1 7817900.0 1979100.0 1402200.0 4436600.0 True False 2561983.9638933334 1324166.3373671377 3629184.323360229 1.0 0.5168519225838013 1.4165523182452393 21.28883001483825 -6.760834548386331 1.6092518051732014 0.7196508721075114 1.419983617793767 0.6943835000845654 0.20323893144799796 0.28152379976125386 1.437079479172487 0.09963626203555004 0.23925208742262366 1.734464644688995e-07 6.760834548386331 0.7003327456862556 VAHILNISPPLNLNPVWFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAHILNISPPLNLNPVWFK 19 0 Q6YN16 Q6YN16 HSDL2 Hydroxysteroid dehydrogenase-like protein 2 0 31355400.0 9047400.0 10434000.0 11874000.0 False True 13725567.253538173 8571971.178785916 9527098.695440914 1.0 0.624525822535767 0.6941132937864569 23.71036243872108 -10.757813901790762 6.980712175995265 1.0069456954649036 0.6593195581612642 0.9696577718110693 0.028408966175797357 0.0030950062478387334 0.00010737679393036108 0.027722335719404304 0.009168954406819411 1.746570410173458e-11 10.757813901790762 -0.34762613730363945 VAHILNISPPLNLNPVWFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAHILNISPPLNLNPVWFK 19 0 Q6YN16 Q6YN16 HSDL2 Hydroxysteroid dehydrogenase-like protein 2 0 21926700.0 9047400.0 6793800.0 6085500.0 False True 11712037.650916351 6415719.0577698285 4978001.442502973 1.0 0.5477884591045403 0.42503290980399927 23.48148876081353 -13.999999999999943 0.18299172222370566 3.3683485285544053 0.3304754377944851 0.999494833891885 0.005556952804563834 12.24491447273975 0.13563088830866563 10.31870495847194 0.08937550666124568 1.000000000000131e-14 13.999999999999943 -3.0378730907599203 VAHLALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAHLALK 7 0 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 0 3868400.0 1022600.0 1689400.0 1156400.0 False True 1340638.5028724878 1437348.1052296218 1036746.820972076 1.0 1.0721369721591028 0.7733231730632193 20.35448884279254 -6.8429401778693935 1.2686479773426091 1.038372645360555 0.7629072834341956 0.9293984748030689 0.033828085995534156 0.1653896470097313 0.5157959155071975 0.02089768460071732 0.048189591536983094 1.435687179248664e-07 6.8429401778693935 -0.2754653619263595 VAHLALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAHLALK 7 0 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 0 3454200.0 1022600.0 1014000.0 1417600.0 False True 1400682.8547259131 969198.1271504081 1082792.076388445 1.0 0.691946877110923 0.7730458559802438 20.417698904315433 -9.872646521360041 6.193798062708473 1.000000027843889 0.7324963665455068 0.9355115648700517 0.03310851948204025 1.2725292121508905e-08 2.3137147452810183e-09 0.03205718948658037 0.010685728714253414 1.340767513763706e-10 9.872646521360041 -0.2675036612983822 VAHLALK(ub)HR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAHLALKHR 9 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 7898000.0 1296400.0 1752800.0 4848800.0 True False 1255246.4916134824 2452702.180731247 3578753.819118016 1.0 1.9539605942881912 2.8510367031720745 20.25953926203447 -6.971867931533991 0.20880452241059144 0.5231057574160466 4.306900990708879 0.99999351909727 0.0019240818769949816 0.07570115181502408 0.006816799693914616 0.02712005803707742 0.09321772111689945 1.0669205212396359e-07 6.971867931533991 3.7837952332928326 VAHLALK(ub)HR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAHLALKHR 9 1 P55036;P55036-2;A6PVX3;Q5VWC4 P55036;Q5VWC4 PSMD4 26S proteasome non-ATPase regulatory subunit 4 1 7174100.0 1296400.0 2543800.0 3333900.0 True False 1078014.040257789 2530096.0444952347 4031003.075788063 1.0 2.346997302456473 3.739286247908345 20.039944537468745 -6.970710338932879 0.2406155269041409 0.5038690298238759 5.6227151029328155 0.9999874052360564 0.0039689546387133194 0.07607286977564753 0.00820099166233497 0.03313644566861765 0.1355855959668755 1.0697681437955229e-07 6.970710338932879 5.11884607310894 VAHPIRPKPPSATSIPAILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAHPIRPKPPSATSIPAILK 20 2 Q9UMS4;F5GY56 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 19070700.0 2282000.0 10374000.0 6414700.0 False True 2991724.0989194377 8826239.63753528 5750968.378147342 1.0 2.950218451201157 1.9222923598551414 21.512545703281642 -10.114729529730532 10.458712070638446 0.9999999992086338 2.436255405528149 0.7224554230921025 0.4196490695152115 7.7818185549523e-09 1.1578273240781884e-09 0.4063234673983089 0.13544115479032104 7.678395362159204e-11 10.114729529730532 1.436255406319515 VAHPIRPKPPSATSIPAILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAHPIRPKPPSATSIPAILK 20 2 Q9UMS4;F5GY56 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 14327000.0 3234800.0 3053700.0 8038500.0 False True 3132113.044639996 4273058.33483513 5932975.700169151 1.0 1.3642733432459089 1.894240602305938 21.578704852833834 -6.965760034274772 0.34475936370665355 0.9455960388768838 2.3306580661375387 0.9999279658197127 0.0031161494228600204 0.07770399370742796 0.013955810213469337 0.0073774332145558385 0.04571499505731108 1.082031653549864e-07 6.965760034274772 1.3850620272606549 VAHPIRPKPPSATSIPAILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAHPIRPKPPSATSIPAILK 20 2 Q9UMS4;F5GY56 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 12060100.0 2282000.0 5564600.0 4213500.0 False True 3125717.0687312083 5318737.572328565 3218358.0797564294 1.0 1.7016055693382215 1.029638322659455 21.575755764804533 -10.361159202358795 5.083061163498908 0.9997930976575387 1.365621945998881 0.2830185761950844 0.27432947970446403 0.0006435884145938837 8.088568287794703e-05 0.2657671059267188 0.0885394588557399 4.353522543171528e-11 10.361159202358795 0.3658288483413423 VAHSFNCTPIEGMLSHQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAHSFNCTPIEGMLSHQLK 19 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 49327000.0 10262000.0 26643000.0 12422000.0 False True 13453581.37734935 22667968.25360056 11136690.600237932 1.0 1.6849021548838057 0.8277863185922991 23.681486937184374 -6.693924459626457 1.8528936992482763 1.4278090973202509 0.8306337028072883 0.38869842098716334 0.28943949001476454 0.40826708513115334 2.720640290715849 0.1248382048989715 0.3234379005387801 2.023371089471896e-07 6.693924459626457 -0.5971753945129625 VAHSFNCTPIEGMLSHQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAHSFNCTPIEGMLSHQLK 19 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 58662100.0 2948200.0 50351000.0 5362900.0 False True 4472634.942290737 41365470.655841395 4302920.464357433 1.0 9.24856850370519 0.962054922853511 22.092693579301034 -6.647240190162577 2.0183812775251453 6.36421257808945 0.9968633424595968 0.18289646662231585 3.5229954113047954 0.5153586943486019 4.021038119384837 1.4171259932957934 3.9017464614942963 2.2529928311658242e-07 6.647240190162577 -5.367349235629853 VAHSFNCTPIEGMLSHQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAHSFNCTPIEGMLSHQLK 19 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 40169000.0 10262000.0 16564000.0 13343000.0 False True 14056138.72012253 15832147.710176885 10191658.207710946 1.0 1.1263511285294767 0.7250681293519636 23.744696998707266 -6.822079231066959 1.3630422991093494 1.0679612649923715 0.7159241763864562 0.889060632090944 0.05579833329040142 0.19079314328178257 0.6959726196724116 0.032165829254205094 0.07409221793079068 1.506332231478357e-07 6.822079231066959 -0.3520370886059153 VAHSFNCTPIEGMLSHQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAHSFNCTPIEGMLSHQLK 19 0 Q9UQ80;Q9UQ80-2;F8VR77;F8W0A3 Q9UQ80 PA2G4 Proliferation-associated protein 2G4 0 24078600.0 2948200.0 12784000.0 8346400.0 False True 3816503.0177102336 12072559.161960835 6827440.841296003 1.0 3.1632515698111363 1.7889258333122517 21.863819901393484 -10.363797743246376 6.067886227469507 0.9997964320627971 2.4760887015616944 0.6060043362696818 0.5610661324661618 0.0015453229006416951 0.00016202353556801348 0.5433204257795897 0.18108331559687033 4.327153054267066e-11 10.363797743246376 1.4762922694988974 VAIDVGYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAIDVGYR 8 0 P15121;E9PCX2;E9PEF9 P15121 AKR1B1 Aldose reductase 0 85946000.0 29470000.0 16129000.0 40347000.0 False True 38635455.38788596 13722616.070349589 36172279.47575263 1.0 0.3551819418867851 0.936245712975195 25.203422067004322 -10.587376475704964 9.2969524236415 1.000051666962287 0.6457138274310001 0.33140684327576986 0.23721829119732876 0.0002540776180140226 1.1276649605396791e-05 0.22971883633879842 0.0765618742685863 2.585970250079126e-11 10.587376475704964 -0.35433783953128684 VAIDVGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAIDVGYR 8 0 P15121;E9PCX2;E9PEF9 P15121 AKR1B1 Aldose reductase 0 49410200.0 17022000.0 6671200.0 25717000.0 False True 16481645.927371724 9335044.949848408 18980946.206537314 1.0 0.5663903344959819 1.151641425266569 23.974356987599506 -6.708251531581853 1.8012886032318822 0.7329537669312134 1.1502056222703068 0.4568540744028321 0.18277134222391656 0.3786050068918597 2.393494535762771 0.08077733020603718 0.2056601001361437 1.9577104922882003e-07 6.708251531581853 0.41725185533909337 VAIDVGYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAIDVGYR 8 0 P15121;E9PCX2;E9PEF9 P15121 AKR1B1 Aldose reductase 0 79176000.0 18284000.0 43537000.0 17355000.0 False True 27738164.739449095 35767482.19386643 13924776.643033283 1.0 1.289468230138459 0.5020078571827619 24.725369000939917 -6.807205511579129 1.426241238308285 1.158288199796559 0.4890948626294362 0.8523994722689657 0.12494366109321677 0.21064140576942403 0.8450021359234181 0.06889318819321456 0.15957583616061521 1.5588146848488435e-07 6.807205511579129 -0.6691933371671228 VAIDVGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAIDVGYR 8 0 P15121;E9PCX2;E9PEF9 P15121 AKR1B1 Aldose reductase 0 75093000.0 29470000.0 23972000.0 21651000.0 False True 40365855.39680484 22912837.775196806 16537479.716341881 1.0 0.5676291893224805 0.40968981218841966 25.266632128527213 -13.99999999997829 0.14003918570930107 3.0654323187491648 0.21432380280520555 0.9996027773023882 0.0049731011623967885 11.934038255750036 0.11724886391795011 6.735508169595911 0.17465927873159218 1.0000000000499906e-14 13.99999999997829 -2.851108515943959 VAIDVGYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAIDVGYR 8 0 P15121;E9PCX2;E9PEF9 P15121 AKR1B1 Aldose reductase 0 34757500.0 17022000.0 10758000.0 6977500.0 False True 14154547.202459186 10700044.518704195 8436462.989685103 1.0 0.7559439638482528 0.5960249288807604 23.754762263033783 -8.599525365841542 0.08877053126231121 1.6120933605640062 2.834196973963887e-06 0.9999853005901944 0.0006368370642202232 0.1991740483497121 0.02283453598323856 0.21270785721501506 0.1866787803303435 2.514633136507099e-09 8.599525365841542 -1.6120905263670322 VAIDVGYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAIDVGYR 8 0 P15121;E9PCX2;E9PEF9 P15121 AKR1B1 Aldose reductase 0 73128000.0 18284000.0 33920000.0 20924000.0 False True 23668998.431522246 32032322.181923598 17116046.698370248 1.0 1.353345063357777 0.723141993012057 24.496495323032367 -6.754558305300041 1.632870663485906 1.20662821032953 0.7214336148343043 0.6683643967780708 0.1485248345455949 0.2921737513696852 1.5339814042469158 0.07181220821183708 0.1735217274788184 1.7597124014234154e-07 6.754558305300041 -0.4851945954952257 VAIFIEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAIFIEK 7 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 44192000.0 13190000.0 12207000.0 18795000.0 False True 17292217.7321417 10385763.182513308 16850273.6943706 1.0 0.6006033085744055 0.974442605071434 24.043619571131867 -10.530222154829282 9.034171046322848 1.0000121131920432 0.7875229580381351 0.3010501649150248 0.1526192537031251 3.723766339694427e-05 1.9363691339195825e-06 0.14778137167967767 0.04925765232523404 2.949699979481192e-11 10.530222154829282 -0.2124891551539081 VAIFIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAIFIEK 7 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 31413800.0 8436300.0 5045500.0 17932000.0 False True 8168494.274297157 7060194.461934909 13235071.251531161 1.0 0.8643201825029608 1.6202583740771426 22.96163873543001 -6.860469617728719 1.183241073424507 0.9262836223516994 1.6572150062302256 0.954216517929043 0.07041093664763164 0.14632519012519402 0.38899528905843167 0.04640081790325681 0.1083798689565424 1.3788924138260933e-07 6.860469617728719 0.7309313838785262 VAIFIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAIFIEK 7 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 26355500.0 4551500.0 17314000.0 4490000.0 False True 6904958.259221323 14224181.42510057 3602549.531963086 1.0 2.0599952803631636 0.5217337160803269 22.719201262678403 -6.7212761823380935 1.7545641872308089 1.6440028177068764 0.5239281023134704 0.5186073255619541 0.445981546496529 0.3528401922323314 2.123469307082223 0.20176481378318886 0.5057768629455847 1.899869705200539e-07 6.7212761823380935 -1.120074715393406 VAIFIEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAIFIEK 7 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 42494000.0 13190000.0 13574000.0 15730000.0 False True 18066699.446347337 12974255.796784637 12014897.969519101 1.0 0.7181309367167077 0.6650300463125395 24.106829632654758 -13.999999999999998 0.23472882942920023 2.8191850730509436 0.6403467845201047 0.9995166027255402 0.0032319285778966756 13.443179437475242 0.153371402702436 11.428423536040421 0.026775771774604128 1.0000000000000041e-14 13.999999999999998 -2.178838288530839 VAIFIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAIFIEK 7 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 18953600.0 8436300.0 5728600.0 4788700.0 False True 7015157.241458499 5697738.89476193 5789995.029552855 1.0 0.8122040174793476 0.8253549892417059 22.742044010864287 -10.087934552090777 6.850110778355507 1.0000001024250371 0.8187795033605274 0.996065850363862 0.005368861739921697 8.40046895843876e-09 1.119505064873126e-09 0.005198380970240213 0.001732792675567186 8.16705439088675e-11 10.087934552090777 -0.1812205990645097 VAIFIEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAIFIEK 7 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 19698100.0 4551500.0 11313000.0 3833600.0 False True 5892006.473478102 10683421.605073772 3135924.1360577396 1.0 1.8132060195730328 0.5322336542184035 22.490327584770853 -6.735161070728455 1.704302101263393 1.4865428412774369 0.532230499352287 0.583080541112554 0.3417363803335512 0.3266400628734055 1.860921320781138 0.15874957737572085 0.3916622060227862 1.8400894242672026e-07 6.735161070728455 -0.9543123419251499 VAIHYINPPNPAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAIHYINPPNPAK 13 0 P78406;E9PQ57 P78406 RAE1 mRNA export factor 0 6412990.0 963890.0 2773000.0 2676100.0 False True 1263669.1243240382 2359279.2090693424 2399202.842963829 1.0 1.8670070856810463 1.8986005092489782 20.269187330951713 -11.084722890929603 0.566383104350367 1.5123290607421828e-14 1.8954907723823928 0.9998943425927858 0.00427972633201224 3.0817716856340662 0.2782032760934122 3.9709335984036347 0.005755421065963354 8.227674634398083e-12 11.084722890929603 1.8954907723823777 VAIHYINPPNPAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAIHYINPPNPAK 13 0 P78406;E9PQ57 P78406 RAE1 mRNA export factor 0 3881990.0 963890.0 1823000.0 1095100.0 False True 1320266.181147819 1742453.8321451626 836459.9342924574 1.0 1.319774646223461 0.6335540107262705 20.332397392474604 -6.779989253304084 1.5359317851750331 1.181064865051467 0.62812100727034 0.7673587768459512 0.13522781865768807 0.2505837505061281 1.1676365541077602 0.06934501372561523 0.1636252649878167 1.65962797472543e-07 6.779989253304084 -0.552943857781127 VAIK(ub)DKQEGIE ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAIKDKQEGIE 11 2 P52435 P52435 POLR2J DNA-directed RNA polymerase II subunit RPB11-a 1 18932600.0 2915600.0 4675000.0 11342000.0 True False 3774301.6750681633 4414832.1403447185 9277872.378747623 1.0 1.1697083382358373 2.4581692661279035 21.847778309626296 -6.931083347670856 0.7378486599281449 0.9811731077213951 2.7301293048871287 0.9967468828921281 0.037135278012004 0.09207910686491058 0.07495367158220315 0.03405273254891817 0.11589666727731422 1.1719704251375392e-07 6.931083347670856 1.7489561971657337 up VAILK(ub)ANLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAILKANLR 9 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 21388200.0 2385100.0 11879600.0 7123500.0 True False 3126889.197341256 10107209.986318119 6386428.553437031 1.0 3.2323530987001776 2.042422404627356 21.576296666975836 -10.246506508539317 5.849491892317519 0.9999359384482124 2.6373877516637805 0.7162826218780922 0.48578717162575585 0.0004058631098598929 5.2279641556052165e-05 0.47037944957459527 0.15678713545897266 5.6688307588580874e-11 10.246506508539317 1.6374518132155682 VAILK(ub)ANLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAILKANLR 9 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 28481400.0 3529900.0 15705800.0 9245700.0 True False 3417845.256669569 21977207.84466502 6823973.804945452 1.0 6.430135419904921 1.996571902027799 21.704655649635733 -6.596019178410037 2.206381719551482 4.66141764289791 2.0105939102093977 0.009069127476869943 2.34949928046531 0.6521513524986924 5.994238931748657 0.8860207772915835 2.614649287898278 2.5350166818895505e-07 6.596019178410037 -2.6508237326885125 VAILK(ub)ANLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAILKANLR 9 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 26773700.0 11622400.0 7892300.0 7259000.0 True False 17632030.51125431 6483857.402178645 5824255.468267282 1.0 0.36773174808426506 0.3303224472388322 24.071695289739438 -13.789608692287837 0.4040332944895753 9.999849025400687 0.32830133303773834 0.9998398605331591 0.0038881457306041674 22.9054976996566 0.2096540825556283 179.81749776135467 0.009470301881929459 1.6232720380848732e-14 13.789608692287837 -9.67154769236295 VAILK(ub)ANLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAILKANLR 9 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 19814700.0 2385100.0 15665500.0 1764100.0 True False 3266935.924903944 14973346.411119048 1347455.912779952 1.0 4.58329968977255 0.4124525071055902 21.639506728498727 -6.679311311220078 1.9042424793869757 3.2685735113187357 0.42837409339076765 0.32102571146298564 1.518912573714846 0.44004896511582414 3.084465895555163 0.6401670286810993 1.6899455639617675 2.092611890839131e-07 6.679311311220078 -2.840199417927968 VAILK(ub)ANLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAILKANLR 9 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 30421800.0 3529900.0 25766600.0 1125300.0 True False 2935268.2510845168 25627790.21153036 1360595.027200667 1.0 8.730987432600568 0.46353345275954155 21.48506092507001 -6.661265907126228 1.9683627885455535 5.971125023303799 0.49789258843979856 0.24102739500190395 3.290680643588046 0.4814410272174541 3.5871177583685228 1.3500320797972 3.6484950942823056 2.1813938925848253e-07 6.661265907126228 -5.473232434864 VAILK(ub)ANLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAILKANLR 9 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 20192900.0 11622400.0 6711600.0 1858900.0 True False 15045425.911754798 6338093.56002944 1520599.2739247018 1.0 0.42126381780110117 0.10106721357330783 23.842821611831887 -8.592362758983837 0.3501736393362444 1.1423571054512462 5.798562563776326e-17 0.9979140325560173 0.01699071283664434 0.22266859398181224 0.1066127717049962 0.1223446483014248 0.08614852033085553 2.5564496348260203e-09 8.592362758983837 -1.1423571054512462 VAIVKPGVPMEIVLNK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VAIVKPGVPMEIVLNK 16 1 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 36267770.0 9127920.0 13440210.0 13699640.0 False True 11966791.514903013 11434983.057528252 12282132.669026196 1.0 0.9555596454812081 1.026351353554582 23.512533059097915 -6.736993533802982 1.6975860419766087 0.9734664295246509 1.026367096241851 0.5913977716828444 0.018673789742507663 0.3232951067599653 1.8281212796390556 0.008706257594322945 0.02143626062564856 1.8323417038466865e-07 6.736993533802982 0.05290066671720006 VAIVKPGVPMEIVLNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAIVKPGVPMEIVLNK 16 1 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 21620500.0 10677000.0 3760400.0 7183100.0 False True 10338064.479294328 5261947.330226945 5301630.621619094 1.0 0.5089876679300924 0.5128262289558656 23.301462769834934 -10.007152314352316 5.015799483087309 1.0000047800670095 0.5109069484384999 0.9999538043561236 0.0015670860061649146 2161598.952996433 0.34283469764946883 127.87831959220688 0.0005364552173688946 9.83666057087891e-11 10.007152314352316 -0.4890978316285096 VAIVKPGVPMEIVLNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAIVKPGVPMEIVLNK 16 1 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 27965100.0 2840400.0 21822000.0 3302700.0 False True 4309094.461055091 17927693.6039358 2649919.897375166 1.0 4.160431795116918 0.6149598068282606 22.038953293904292 -6.671577290377932 1.93163222521967 3.0144865069000364 0.6291057873780374 0.28619795300982975 1.3419832824961706 0.45745127278352354 3.2920827517974476 0.5589881651407168 1.4904925126120887 2.130211425037868e-07 6.671577290377932 -2.385380719521999 VAIVKPGVPMEIVLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAIVKPGVPMEIVLNK 16 1 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 36839300.0 8165300.0 13096000.0 15578000.0 False True 11184232.068935541 12517375.417319277 11898797.23898082 1.0 1.1191984697891393 1.0638904097877224 23.41496286576972 -10.594971118955524 6.614659583688869 0.9998083522164417 1.0915444397884309 0.785075616882685 0.022579420944451194 6.394850868782542e-05 3.915698664688564e-06 0.021908017301063436 0.007287476773738874 2.5411416885526717e-11 10.594971118955524 0.09173608757198914 VAIVKPGVPMEIVLNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAIVKPGVPMEIVLNK 16 1 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9;A0A087WW13;A0A087X214 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 17388400.0 10677000.0 3100100.0 3611300.0 False True 8878398.571299313 3083399.145978326 4366406.133235372 1.0 0.34729226461468543 0.4918010943268982 23.08186804526921 -10.06417481226106 7.540633429031787 1.0000000509392586 0.41954667947304625 0.9555796156083449 0.058995482686944434 5.04917878180463e-08 6.321276462336154e-09 0.0571221355940723 0.019040710162333635 8.626312514516761e-11 10.06417481226106 -0.5804533714662123 VAK(ub)GSQGPLPFHEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAKGSQGPLPFHEK 14 1 B4DLN1;Q9UBX3;Q9UBX3-2;I3L1E8;F6RGN5 B4DLN1 SLC25A10 Mitochondrial dicarboxylate carrier 1 10623000.0 2181000.0 5138100.0 3303900.0 True False 3308736.45245781 4221165.910841469 2650882.7168491874 1.0 1.2757637156945165 0.8011767497771082 21.657848951976636 -6.749200450943975 1.6530346537177216 1.1623091721859953 0.800303752693312 0.6454361329302738 0.11587281927191244 0.3014380905498624 1.620396806166692 0.05538227066775484 0.13455407971449215 1.7815562908063436e-07 6.749200450943975 -0.3620054194926833 VALALCLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VALALCLGK 9 0 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 49291000.0 14230000.0 17649000.0 17412000.0 False True 18655667.803516015 15015837.995263161 15610373.26769785 1.0 0.8048941562109688 0.836763038027284 24.153110668406804 -10.431528262853854 4.974212533720254 1.0002664216135198 0.8208285971191095 0.9768221519333613 0.013010416520564446 3.849710383424207e-05 4.399578177202809e-06 0.01261589589830296 0.004199093875938903 3.702301109194563e-11 10.431528262853854 -0.17943782449441026 VALALCLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VALALCLGK 9 0 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 32792100.0 21621000.0 7135300.0 4035800.0 False True 20934653.18973705 9984462.500097938 2978702.9085952234 1.0 0.4769346981583958 0.1422857537499353 24.319389682333178 -8.355881429957261 0.3296511308925787 1.133148706498478 7.954892553345898e-22 0.9984245162722273 0.0140100285050426 0.12392737320764309 0.08579169482376224 0.09245011716329579 0.09126701415619834 4.406751591644029e-09 8.355881429957261 -1.133148706498478 VALALCLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VALALCLGK 9 0 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 143191000.0 48551000.0 54892000.0 39748000.0 False True 73655416.5535437 45096093.726846494 31891790.37783272 1.0 0.6122576700664499 0.43298635552008624 26.13428828787858 -13.999999999999998 0.10339279011010916 2.8972986108401915 0.070473651094135 0.9997766238263239 0.0035367647044696835 12.055494773519056 0.09642813094228032 4.840524044593223 0.3227449180693931 1.0000000000000041e-14 13.999999999999998 -2.8268249597460566 VALALCLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VALALCLGK 9 0 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 89265000.0 14230000.0 27481000.0 47554000.0 False True 19491215.551290557 26266798.552485574 36322724.60537256 1.0 1.3476223934502838 1.863543323390498 24.216320729929695 -6.965433614258262 0.35053708483105095 0.9504495279516385 2.278139389004587 0.9999217996915475 0.003137213427803943 0.07781419513611636 0.014343269392243653 0.007072200933674533 0.044329046091564205 1.0828452249197417e-07 6.965433614258262 1.3276898610529486 VALALCLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VALALCLGK 9 0 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 36480200.0 21621000.0 2231200.0 12628000.0 False True 17978819.472704154 2219180.0827414733 15268456.414724987 1.0 0.1234330255170915 0.8492468839739951 24.099794957767454 -10.853005619441515 9.962295266488967 1.0176308952040234 0.48633995476227854 0.4004040635376295 0.2963122669100111 0.10314859519475575 0.0015219624593670197 0.2550428232557125 0.09563437291828664 1.4027955533330178e-11 10.853005619441515 -0.5312909404417449 VALALCLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VALALCLGK 9 0 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 122511000.0 48551000.0 43261000.0 30699000.0 False True 62850226.58328795 40853487.32052474 25112096.998340078 1.0 0.6500133657654592 0.39955459770796525 25.90541460997103 -7.923135913289625 0.17712556307092142 1.2847676883898496 5.36186454057314e-15 0.9999150694104819 0.002269385308214103 0.11448419215997102 0.028190044702646667 0.0756309824608617 0.10186617062119636 1.1936145020637787e-08 7.923135913289625 -1.2847676883898442 down VALALCLGKPADVYLIDEPSAYLDSEQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VALALCLGKPADVYLIDEPSAYLDSEQR 28 1 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 89318000.0 25704000.0 36174000.0 27440000.0 False True 38994847.21411073 29718467.07124797 22016471.972620778 1.0 0.7621126685808376 0.5645995187962646 25.216780162807297 -6.973262026908521 0.1623374878760346 1.1936094496629635 0.12785096326570095 0.9999979335850464 0.0002558191035343741 0.07525778656760798 0.005023156441808158 0.008940673643435662 0.023500606525124892 1.0635011726148542e-07 6.973262026908521 -1.0657584863972625 VALALCLGKPADVYLIDEPSAYLDSEQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VALALCLGKPADVYLIDEPSAYLDSEQR 28 1 P61221 P61221 ABCE1 ATP-binding cassette sub-family E member 1 0 60504000.0 25704000.0 13525000.0 21275000.0 False True 33274334.701588754 12772321.86056948 17403168.299934376 1.0 0.3838490528845837 0.5230207742997616 24.987906484899746 -10.030547642873918 7.410998612983614 1.0000000357298973 0.453434913593017 0.9536277291104814 0.05681661734865956 3.3548236850954385e-08 4.369196173374328e-09 0.05501245688365118 0.018337484398266456 9.320782141018154e-11 10.030547642873918 -0.5465651221368802 VALAVSLNLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VALAVSLNLR 10 0 F5H8H2;Q03426;F5GXC0;F5H092;F5H163;F5H368;A0A1W2PS16 F5H8H2 MVK Mevalonate kinase 0 41886000.0 12260000.0 12578000.0 17048000.0 False True 18599316.326058086 10333357.627637459 13678455.327596156 1.0 0.5555772828681976 0.7354278559385709 24.148746255914027 -10.158177181332194 5.305729188957756 1.000012109583072 0.6455025694032379 0.8381912954423123 0.07342368899543861 1.0517860875742789e-05 1.6688945378392667e-06 0.07109460768087195 0.023697393724629884 6.947408228106475e-11 10.158177181332194 -0.35450954017983416 VALAVSLNLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VALAVSLNLR 10 0 F5H8H2;Q03426;F5GXC0;F5H092;F5H163;F5H368;A0A1W2PS16 F5H8H2 MVK Mevalonate kinase 0 37782000.0 12260000.0 12612000.0 12910000.0 False True 15870811.680729758 11910131.113160979 10560512.46778628 1.0 0.7504424696578176 0.6654046863027674 23.919872578006476 -13.999999999999998 0.1502820553262877 2.207241513647783 0.5721489607538093 0.9995652997137363 0.0029605241819134482 11.958797489957604 0.12210421170456799 4.215518633657414 0.08407841056963662 1.0000000000000041e-14 13.999999999999998 -1.635092552893974 VALDMTTLTIMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VALDMTTLTIMR 12 0 A0A087X2I1;P62333;H0YJC0;H0YJS8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 0 4007400.0 1289600.0 1663600.0 1054200.0 False True 1690678.0885041635 1415397.3646620119 945121.4966004525 1.0 0.8371773280117992 0.5590191905998224 20.689170560633563 -6.963006081328082 0.3907659227958855 1.0169383483819958 0.3692514030484488 0.9998659586395213 0.0021079366112492287 0.07864425452957943 0.01728750926481692 0.003589833519155304 0.023390585259263616 1.0889148453966809e-07 6.963006081328082 -0.647686945333547 VALDMTTLTIMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VALDMTTLTIMR 12 0 A0A087X2I1;P62333;H0YJC0;H0YJS8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 0 8546200.0 3244500.0 1795700.0 3506000.0 False True 3141505.1234495128 2512732.374451791 2587673.4222545335 1.0 0.7998498413055901 0.8237049823471727 21.583024502287127 -10.413699874812261 6.772712463604691 1.0000201292971218 0.8117774118935824 0.9880963213594157 0.00973882054900043 2.9603798195813926e-06 2.562767883316563e-07 0.00943057991784001 0.0031431908164984337 3.857448398655014e-11 10.413699874812261 -0.18824271740353937 VALDMTTLTIMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VALDMTTLTIMR 12 0 A0A087X2I1;P62333;H0YJC0;H0YJS8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 0 6344800.0 1289600.0 2103700.0 2951500.0 False True 1766399.970129606 2010751.5779943916 2254416.488050576 1.0 1.138333113675753 1.2762774717920553 20.752380622156455 -6.97116014656713 0.2287890915205284 0.943041933706687 1.4755044054597828 0.9999900684988511 0.00035540222545788993 0.0759280509321478 0.0076696717779071106 0.0035762712646809068 0.013733029446009185 1.0686607367366459e-07 6.97116014656713 0.5324624717530958 VALGNTWK(ub)ENLTELSGGQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VALGNTWKENLTELSGGQR 19 1 O95347;O95347-2;A0A0C4DGE5 O95347 SMC2 Structural maintenance of chromosomes protein 2 1 42207100.0 6255100.0 12062000.0 23890000.0 True False 9489444.009064103 9909441.859163845 19168131.02864103 1.0 1.0442594792380429 2.0199424761168374 23.177892130873616 -6.916387650318704 0.85109215790559 0.9755442720632447 2.1649090342084243 0.9931171502622499 0.039052344996163446 0.10034402463124667 0.11697406427809794 0.03301914321534962 0.09573544447728213 1.212306265420149e-07 6.916387650318704 1.1893647621451797 up VALLDVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VALLDVFR 8 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 21281100.0 6416300.0 5987200.0 8877600.0 False True 8411831.43553759 5093933.097922812 7959031.111952362 1.0 0.6055676622812955 0.9461710179221762 23.00398850955666 -10.14801241621695 7.470055573075734 1.0000000968515694 0.7758693401017359 0.3660275721265953 0.13905073766664466 2.2418754891522884e-07 2.5514037835305033e-08 0.134635355995282 0.044878432605064286 7.111931807791569e-11 10.14801241621695 -0.22413075674983352 VALLDVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VALLDVFR 8 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 11179400.0 4787100.0 2626200.0 3766100.0 False True 4635136.1308260625 3674855.3554520747 2779645.4294217923 1.0 0.7928257664348579 0.5996901387503393 22.144180279778787 -6.971970471391976 0.20576432067574868 1.1067455623788172 0.28040423215238247 0.9999939432526588 0.00040223945009218817 0.07566845352745837 0.0066916986592584875 0.0059828707699550445 0.020214373247554436 1.0666686438406754e-07 6.971970471391976 -0.8263413302264346 VALLDVFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VALLDVFR 8 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 14703400.0 2024400.0 10525000.0 2154000.0 False True 3071162.803464274 8646731.517799672 1728260.9558682614 1.0 2.815458531877943 0.5627383067803445 21.550353561457243 -6.692209265617124 1.8584463132145075 2.135800181258417 0.5702828835359437 0.3808491108635953 0.7674682982086557 0.4119322750979839 2.7601018992913695 0.3301462021564047 0.8573750053686907 2.0313779517680995e-07 6.692209265617124 -1.5655172977224732 VALLDVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VALLDVFR 8 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 27452300.0 6416300.0 10200000.0 10836000.0 False True 8788579.50398775 9749330.273110598 8276759.974425233 1.0 1.1093180949989603 0.9417631109407063 23.06719857107955 -6.7306543246648305 1.7209614260781099 1.0657388098525367 0.9418527329547495 0.5622767117872891 0.04595224611421019 0.33499712145469923 1.944061180505782 0.021157893195245477 0.05246068433233687 1.8592837573847366e-07 6.7306543246648305 -0.12388607689778719 VALLDVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VALLDVFR 8 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 13167700.0 4787100.0 4590900.0 3789700.0 False True 3980685.754487864 4566167.910477698 4582108.748406978 1.0 1.1470807273168335 1.1510852729937457 21.924585555213064 VALLDVFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VALLDVFR 8 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 8418800.0 2024400.0 3189000.0 3205400.0 False True 2620625.706889831 3011529.346643701 2622050.0901814215 1.0 1.1491642391838537 1.0005435279398525 21.321479883549692 -6.645318240116349 2.0250963967859907 1.0971478052315602 1.001164123481458 0.17535652806198632 0.06373849072138367 0.5200933608853752 4.082681032891734 0.025572722962385278 0.07059423910369222 2.2629854408407855e-07 6.645318240116349 -0.0959836817501023 VALLSGGGSGHEPAHAGFIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VALLSGGGSGHEPAHAGFIGK 21 0 Q3LXA3;H0YCY6;Q3LXA3-2;E9PJG8 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 0 13184500.0 2995700.0 5880800.0 4308000.0 False True 3927391.7104000715 5003407.563178856 3862249.4852539822 1.0 1.273977217482382 0.9834133618570343 21.90514006609823 -6.659451898676356 1.975060143404837 1.1764362811184579 0.9846309681871216 0.23322661493768793 0.11666871721335809 0.48571565200499445 3.641801992470494 0.04773676973633428 0.1293071833364555 2.1905244314036026e-07 6.659451898676356 -0.1918053129313363 VALNAK(ub)VVGGPHGDKDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VALNAKVVGGPHGDKDK 17 2 Q9Y597;Q9Y597-2 Q9Y597 KCTD3 BTB/POZ domain-containing protein KCTD3 1 4597800.0 1064500.0 1258800.0 2274500.0 True False 1030708.0301778408 1761445.4045552784 1678740.2164626175 1.0 1.7089664123906694 1.6287252716687999 19.975204286056286 -10.252408533129476 6.124619983869991 0.9999823565909722 1.6688458420297327 0.9893207556798441 0.032758308524577846 7.892696867012836e-06 9.633629216869518e-07 0.03171893043800733 0.01057269861380057 5.592312950128984e-11 10.252408533129476 0.6688634854387605 VALNAK(ub)VVGGPHGDKDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VALNAKVVGGPHGDKDK 17 2 Q9Y597;Q9Y597-2 Q9Y597 KCTD3 BTB/POZ domain-containing protein KCTD3 1 4318100.0 1064500.0 1963300.0 1290300.0 True False 885178.9153458943 1952723.3132154632 1560095.7643268628 1.0 2.2060210420312747 1.7624637655509865 19.755609561490562 -10.174411431390578 4.927380072287847 0.9999158385113769 1.9842424037933744 0.8678146000866352 0.18108149985364563 24123146.43138929 49811252.67894437 15065.128509649954 0.061989017343862515 6.692502908654676e-11 10.174411431390578 0.9843265652819975 VALNVSCANLLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VALNVSCANLLDK 13 0 O75131;A0A087WYQ3;E5RHZ0;A0A087WXR6;A0A087WUS8;E5RFT7 O75131 CPNE3 Copine-3 0 63855000.0 17226000.0 22606000.0 24023000.0 False True 22583452.81682129 19233272.917497817 21537330.404887754 1.0 0.8516533354532887 0.9536774814542828 24.428762742921297 -10.161479606758727 6.022986255327669 1.0000008666928604 0.902665408457476 0.5482424347494061 0.041651183190945205 4.847438649610724e-07 6.749890969013068e-08 0.04032894377250239 0.01344286157069654 6.894779683472764e-11 10.161479606758727 -0.09733545823538436 VALNVSCANLLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VALNVSCANLLDK 13 0 O75131;A0A087WYQ3;E5RHZ0;A0A087WXR6;A0A087WUS8;E5RFT7 O75131 CPNE3 Copine-3 0 24600800.0 14864000.0 4496500.0 5240300.0 False True 14392150.45614223 6291975.89893773 3867708.224369772 1.0 0.43718108132009303 0.2687373395765971 23.778778837986643 -13.999999999999536 0.1690552954412329 3.831360773980827 0.11864644574669259 0.9995155126311605 0.0068822811606360675 12.082469373878292 0.13018318734570788 11.217698570043888 0.13852034321435722 1.0000000000010675e-14 13.999999999999536 -3.7127143282341346 VALNVSCANLLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VALNVSCANLLDK 13 0 O75131;A0A087WYQ3;E5RHZ0;A0A087WXR6;A0A087WUS8;E5RFT7 O75131 CPNE3 Copine-3 0 73574000.0 17226000.0 27313000.0 29035000.0 False True 23594917.715146247 26106221.347987268 22177530.99459548 1.0 1.1064340915768036 0.9399283041516645 24.49197280444419 -6.73403330664043 1.7084038094708764 1.0637617738188607 0.9399498766344856 0.5779056352440994 0.04473001509681843 0.3287322112778394 1.8813835943096053 0.020732845152412572 0.05121625931659167 1.844873927838037e-07 6.73403330664043 -0.12381189718437513 VALNVSCANLLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VALNVSCANLLDK 13 0 O75131;A0A087WYQ3;E5RHZ0;A0A087WXR6;A0A087WUS8;E5RFT7 O75131 CPNE3 Copine-3 0 25502600.0 14864000.0 1671400.0 8967200.0 False True 12360074.586849555 1662395.836453075 10842200.060351757 1.0 0.13449723339224615 0.8771953586661416 23.55918411342092 -10.8074186741588 9.53111189317372 1.0072168534340253 0.5058462960292062 0.371169235195731 0.30320523997378385 0.04602223900720841 0.0009299030499479466 0.29057607417720005 0.09785907040844066 1.5580497674005758e-11 10.8074186741588 -0.5013705574048192 VALNVSCANLLDKDIGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VALNVSCANLLDKDIGSK 18 1 O75131;A0A087WYQ3;E5RHZ0;A0A087WXR6;A0A087WUS8;E5RFT7 O75131 CPNE3 Copine-3 0 37071800.0 6584800.0 15483000.0 15004000.0 False True 8632736.567293907 13172996.752261316 13451530.008530831 1.0 1.5259352175958545 1.55819998718523 23.04138653385437 -11.556262283596434 0.4554175947667484 9.507225025551201e-11 1.5581460214516583 0.9997953880655384 0.003660061279718592 4.263807622573146 0.22553412154471136 4.195462370042034 0.007189774310045702 2.778035021516451e-12 11.556262283596434 1.558146021356586 VALNVSCANLLDKDIGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VALNVSCANLLDKDIGSK 18 1 O75131;A0A087WYQ3;E5RHZ0;A0A087WXR6;A0A087WUS8;E5RFT7 O75131 CPNE3 Copine-3 0 13312900.0 6765200.0 1744500.0 4803200.0 False True 6550442.429083263 2441087.9474473214 3545097.827088696 1.0 0.3726600109649315 0.5411997533706794 22.643160921575518 -10.66717291913135 10.153477368031211 1.0002267272255125 0.45692988216832925 0.9326304428692254 0.0688060617123664 0.00035327785507222606 1.1580249161906987e-05 0.06664712252773289 0.02220706092750957 2.1519247515856147e-11 10.66717291913135 -0.5432968450571833 VALNVSCANLLDKDIGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VALNVSCANLLDKDIGSK 18 1 O75131;A0A087WYQ3;E5RHZ0;A0A087WXR6;A0A087WUS8;E5RFT7 O75131 CPNE3 Copine-3 0 79143000.0 9786000.0 54005000.0 15352000.0 False True 14846077.452431045 44367385.80700905 12317670.470979353 1.0 2.9884921420603185 0.8296919176426858 23.823578464768925 -6.664548382544794 1.9565689354844764 2.2751176338230352 0.8385625214739262 0.2552287129105427 0.8457375926933894 0.47372867040590866 3.490753701596037 0.3486397604537066 0.938194589127221 2.1649686776964484e-07 6.664548382544794 -1.436555112349109 VALNVSCANLLDKDIGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VALNVSCANLLDKDIGSK 18 1 O75131;A0A087WYQ3;E5RHZ0;A0A087WXR6;A0A087WUS8;E5RFT7 O75131 CPNE3 Copine-3 0 40887800.0 6584800.0 18630000.0 15673000.0 False True 9019378.50752903 17806864.998828493 11971360.195567224 1.0 1.9742895792613657 1.327293248151632 23.104596595377263 -10.493877554750291 5.003086434709294 0.9980889701379462 1.6507914137065243 0.5742907471167937 0.2641351461120291 0.005644096383388023 0.0005709681359399209 0.2563733453482264 0.08524925183664989 3.207173429469981e-11 10.493877554750291 0.6527024435685781 VALNVSCANLLDKDIGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VALNVSCANLLDKDIGSK 18 1 O75131;A0A087WYQ3;E5RHZ0;A0A087WXR6;A0A087WUS8;E5RFT7 O75131 CPNE3 Copine-3 0 32291200.0 9786000.0 14565000.0 7940200.0 False True 12668169.910898987 13754444.946336016 6495165.073332027 1.0 1.0857483790537463 0.5127153423908491 23.594704786861374 -6.8688000510667555 1.1403403212748986 1.0481674024723886 0.47990023807621257 0.9634752559857995 0.048229475224040405 0.13801508738083146 0.33616672726377234 0.03284513127020212 0.07760911581170805 1.3526951999556205e-07 6.8688000510667555 -0.5682671643961761 VALRGEDVPLTEQTVSQVLQSAK(ub)EQIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VALRGEDVPLTEQTVSQVLQSAKEQIK 27 2 F8VVA7;P61923;P61923-4;P61923-3;F8VYK5;F8W651;P61923-2 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 28458800.0 4483800.0 12781000.0 11194000.0 True False 5804367.488911586 12069726.114598058 9156806.860139402 1.0 2.0794214249279603 1.577571867672433 22.468707432224118 -10.47029449683004 5.510754386843136 0.9990018090510123 1.82849664630019 0.7841991261668269 0.20487922381962378 0.0025152269581183474 0.00024176907504164095 0.19858032400074033 0.06612448515310752 3.386144624448036e-11 10.47029449683004 0.8294948372491776 VALSEK(ub)ETR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VALSEKETR 9 1 H3BTI9;H3BP07;H3BTW6;J3KNN3;P15735-2;P15735 H3BTI9 PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1 7776500.0 1193500.0 2119700.0 4463300.0 True False 1810626.7565375483 1741422.9737083062 3581126.798666113 1.0 0.9617791007564805 1.977838218581439 20.78805774841766 -6.898157165227723 0.9728275423235262 0.9555935265594808 2.0805938579867282 0.9856274661692012 0.05637316877475583 0.11277511173527845 0.1851612620040759 0.04360667326952696 0.11244568196622581 1.264278739506642e-07 6.898157165227723 1.1250003314272474 VALSEK(ub)ETR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VALSEKETR 9 1 H3BTI9;H3BP07;H3BTW6;J3KNN3;P15735-2;P15735 H3BTI9 PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1 2147060.0 425320.0 525840.0 1195900.0 True False 582572.297840823 502606.6500796547 913453.0503336225 1.0 0.8627369546105377 1.5679651327725963 19.152077575300815 -6.856208454927557 1.2046345716723026 0.9261471074272394 1.5997407434999933 0.9488703819659413 0.06902987115149704 0.15076508709931638 0.41788771080952625 0.044755360868005856 0.10407338096607945 1.3924882687425154e-07 6.856208454927557 0.6735936360727539 VALSEK(ub)ETR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VALSEKETR 9 1 H3BTI9;H3BP07;H3BTW6;J3KNN3;P15735-2;P15735 H3BTI9 PHKG2 Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1 8634300.0 1193500.0 2336600.0 5104200.0 True False 1545009.2774022005 2206566.1559635215 4175287.973514696 1.0 1.4281895832196372 2.702435535231919 20.55918407051011 -6.951632417337733 0.5406313160667435 0.9813172980336927 3.2082156173536043 0.9993232049511017 0.01881059891705455 0.08283691276206806 0.03330104197395753 0.020671626415604334 0.10553616836713633 1.1178089502255923e-07 6.951632417337733 2.2268983193199117 up VALSEPQPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VALSEPQPER 10 0 Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5;Q9BXP5-5;H7C3A1;H7C1K0 Q9BXP5-4 SRRT Serrate RNA effector molecule homolog 0 574773000.0 186780000.0 291940000.0 96053000.0 False True 244870388.780093 248383689.973207 86114356.96543652 1.0 1.014347595111915 0.3516732153464742 27.867443084070658 -6.901954851072482 0.9488561628537184 1.0260933376130796 0.27929303354701235 0.9875131975028991 0.03453587391001904 0.10997971358143348 0.169428026355519 0.027195379280685678 0.07147521821853546 1.2532714573268463e-07 6.901954851072482 -0.7468003040660673 down VALSEPQPER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VALSEPQPER 10 0 Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5;Q9BXP5-5;H7C3A1;H7C1K0 Q9BXP5-4 SRRT Serrate RNA effector molecule homolog 0 926610000.0 363390000.0 355790000.0 207430000.0 False True 351854383.35962945 497858802.42033863 153097860.23338795 1.0 1.4149569423197392 0.4351171037619475 28.390403245148022 -6.791649643709152 1.4897844841732844 1.2314210180481169 0.4242239856243658 0.8066166499593938 0.17659445608457944 0.23289752975494113 1.021129146889678 0.09329485697588374 0.21816193926166544 1.6156614259697955e-07 6.791649643709152 -0.8071970324237511 down VALSEPQPER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VALSEPQPER 10 0 Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5;Q9BXP5-5;H7C3A1;H7C1K0 Q9BXP5-4 SRRT Serrate RNA effector molecule homolog 0 1430730000.0 855280000.0 379200000.0 196250000.0 False True 1297522289.3434718 311528797.2968771 157461101.48056936 1.0 0.24009514122066167 0.12135521892286143 30.273112175959852 -13.999999999999998 0.26129673363433437 6.600675924447523 0.07849256711971046 0.9995649916099666 0.008118323711769163 14.474782670574816 0.16176360682991126 42.83983592695704 0.05155914544416891 1.0000000000000041e-14 13.999999999999998 -6.522183357327813 VALSEPQPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VALSEPQPER 10 0 Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5;Q9BXP5-5;H7C3A1;H7C1K0 Q9BXP5-4 SRRT Serrate RNA effector molecule homolog 0 569130000.0 186780000.0 256340000.0 126010000.0 False True 255837613.5397085 245014051.1969776 96249033.25741257 1.0 0.9576936237288228 0.37621142538711877 27.93065314559355 -6.921529557988858 0.8133070279311682 1.012136627444845 0.2790635281490461 0.9945952129318277 0.020923715474764865 0.09728030436375364 0.10101369837004873 0.018175442675591257 0.05526587196623817 1.198037582235537e-07 6.921529557988858 -0.7330730992957988 down VALSEPQPER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VALSEPQPER 10 0 Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5;Q9BXP5-5;H7C3A1;H7C1K0 Q9BXP5-4 SRRT Serrate RNA effector molecule homolog 0 1100167000.0 363390000.0 655800000.0 80977000.0 False True 302174885.9065707 652267075.2338916 97908916.30465499 1.0 2.1585747381917297 0.3240140755275321 28.1708085205823 -6.73601200524206 1.7011998625317803 1.692501155459123 0.3238209693095163 0.5869762478251415 0.48685065153217955 0.32506636767027564 1.845573218199694 0.2265410459733308 0.5583844559090443 1.8364875764527332e-07 6.73601200524206 -1.3686801861496067 VALSEPQPER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VALSEPQPER 10 0 Q9BXP5-4;Q9BXP5-2;Q9BXP5-3;Q9BXP5;Q9BXP5-5;H7C3A1;H7C1K0 Q9BXP5-4 SRRT Serrate RNA effector molecule homolog 0 1409017000.0 855280000.0 495150000.0 58587000.0 False True 1107176820.0892782 467594467.2281682 47924767.15338456 1.0 0.4223304342575229 0.043285558624249466 30.0442384980523 -8.298790772146031 0.45981863944181484 1.0553480257254513 1.0992891548710014e-15 0.9951318088068313 0.027446575565692174 0.13322158331666284 0.1360908247608502 0.06556209603406982 0.07610336726054948 5.025846588742573e-09 8.298790772146031 -1.0553480257254502 VALSHHLVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VALSHHLVAR 10 0 I3L2B0;A0A494C0R8;K7EIG1;O75153 I3L2B0 CLUH Clustered mitochondria protein homolog 0 3690300.0 1024600.0 1244600.0 1421100.0 False True 1343260.522240514 1058910.531412802 1274058.2041537678 1.0 0.7883135950772784 0.9484818343568089 20.35730770856016 -10.274427575417924 5.778472000127208 1.000008444290419 0.8683977147833473 0.4737245566122458 0.06538840987247913 7.113893254072865e-06 8.932566626049232e-07 0.06331611742678757 0.02110401853925747 5.3158464117047717e-11 10.274427575417924 -0.13161072950707164 VALSSETEVALAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VALSSETEVALAR 13 0 P27816-6;P27816;E7EVA0;P27816-2 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 1394100.0 0.0 1394100.0 0.0 False True 0.0 1950771.4001354594 0.0 0.0 VALSSETEVALAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VALSSETEVALAR 13 0 P27816-6;P27816;E7EVA0;P27816-2 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 22103800.0 2275000.0 14927000.0 4901800.0 False True 3451341.3247783184 12263160.224816693 3932957.081464741 1.0 3.5531577641351837 1.1395445165706284 21.718725727309305 -6.632944169353051 2.069634719300654 2.6784384560313277 1.1493435007821773 0.1282052535784861 1.094356005748343 0.5514087266231389 4.504770373119586 0.43188846015240206 1.2122269038082258 2.328390564245104e-07 6.632944169353051 -1.5290949552491504 VALSSETEVALAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VALSSETEVALAR 13 0 P27816-6;P27816;E7EVA0;P27816-2 P27816-6 MAP4 Microtubule-associated protein 4;Microtubule-associated protein 0 12323600.0 2275000.0 6002300.0 4046300.0 False True 2945032.346954342 5668266.728554253 3309914.918544043 1.0 1.924687426410169 1.123897644780388 21.489852049401755 -10.232406704658915 4.283827906573418 0.999738946546206 1.5242925356136745 0.3636827681099547 0.3269210594704371 230548594.63803065 292.98058474449044 613958.6561181899 0.11191377423199485 5.855895194205878e-11 10.232406704658915 0.5245535890674685 VALTGLTVAEYFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VALTGLTVAEYFR 13 0 P06576;H0YH81;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 42338600.0 9319600.0 21573000.0 11446000.0 False True 12218085.851134788 18354392.49089539 10261677.71778483 1.0 1.5022314227060924 0.8398760528296458 23.54251494696375 -6.703926204681408 1.816680763425263 1.3106524230522507 0.8416812677490091 0.4363306014182362 0.2118490704933321 0.3874023293141292 2.4882766215211327 0.09293355408554764 0.23786565256828882 1.97730559533609e-07 6.703926204681408 -0.4689711553032416 VALTGLTVAEYFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VALTGLTVAEYFR 13 0 P06576;H0YH81;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 95311000.0 45871000.0 18169000.0 31271000.0 False True 44414850.21351589 25423976.450083297 23080186.990108833 1.0 0.5724206279625484 0.5196502268758141 25.404538790051735 -13.999999999999998 0.29507497475462263 4.791889307069207 0.5059915142698919 0.9996388229643517 0.004087567312488004 16.274614773696094 0.17238107352663665 37.571129431376704 0.019484016123958035 1.0000000000000041e-14 13.999999999999998 -4.2858977927993145 VALTGLTVAEYFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VALTGLTVAEYFR 13 0 P06576;H0YH81;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 67034600.0 9319600.0 25788000.0 31927000.0 False True 12765307.972720144 24648600.890487887 24386500.157205082 1.0 1.930905305470319 1.9103730367743406 23.60572500848664 -10.547544696266428 6.193463922038629 0.9985484839183474 1.9206391711222168 0.999627098208605 0.008382263594478826 0.0001681968170425563 1.2287392004640314e-05 0.008125388823161384 0.0027053639420779466 2.8343619145758256e-11 10.547544696266428 0.9220906872038694 VALTGLTVAEYFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VALTGLTVAEYFR 13 0 P06576;H0YH81;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 78636000.0 45871000.0 14969000.0 17796000.0 False True 38143768.92985576 14888359.02588612 21517061.320592813 1.0 0.39032217957446663 0.5641042278795647 25.18494406548601 -10.845836020268571 10.983063871115336 1.0105957517434538 0.47721320372724185 0.9234678930444856 0.07094622413386475 0.017522242606483985 0.00024595072630309567 0.0653909828460505 0.022897795378896423 1.4261459722804412e-11 10.845836020268571 -0.533382548016212 VALVLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VALVLLR 7 0 Q4KMP7 Q4KMP7 TBC1D10B TBC1 domain family member 10B 0 138052000.0 40947000.0 36900000.0 60205000.0 False True 53681913.53131201 31394663.835073408 53975564.12713931 1.0 0.5848275847462345 1.0054701961333032 25.677932762592615 -10.93069552208669 11.23830213858692 1.034085813094961 0.7951488904397689 0.24024838606444388 0.1717266269950259 0.09631847769607833 0.000593976936319512 0.10919906117821644 0.055424530537675654 1.173017463812162e-11 10.93069552208669 -0.23893692265519217 VALVLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VALVLLR 7 0 Q4KMP7 Q4KMP7 TBC1D10B TBC1 domain family member 10B 0 206056000.0 75969000.0 45530000.0 84557000.0 False True 73557405.67832826 63710366.43581334 62408985.04437434 1.0 0.8661312324475292 0.8484391811926218 26.13236726194653 -13.999999999999961 0.2852420854308308 2.1231834398419105 0.8433826703303557 0.9996168220374638 0.001324486097556623 15.688812559488904 0.16927006769886305 10.311483134693315 0.006828578900221098 1.00000000000009e-14 13.999999999999961 -1.2798007695115547 VALVLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VALVLLR 7 0 Q4KMP7 Q4KMP7 TBC1D10B TBC1 domain family member 10B 0 32354300.0 8822900.0 9120400.0 14411000.0 False True 13384984.340389723 7492793.3619895615 11562659.533434324 1.0 0.5597909696001481 0.863853049012806 23.67411211532655 -10.107936659755897 5.549080599821905 1.0000032324322703 0.7118220093064104 0.544971864916158 0.12413282411534128 4.96415977259041e-06 7.981880378869736e-07 0.12019243854334934 0.04006369670966662 7.799438541552993e-11 10.107936659755897 -0.2881812231258599 VALVLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VALVLLR 7 0 Q4KMP7 Q4KMP7 TBC1D10B TBC1 domain family member 10B 0 243227000.0 40947000.0 100410000.0 101870000.0 False True 56086212.451067746 95973554.18853286 77810404.0785067 1.0 1.7111790936545181 1.38733568693718 25.741142824115506 -10.145337254287599 4.682525130735353 0.9999453244306532 1.5492573903017413 0.7931955671623528 0.13220851719053728 7.547100581184594e-05 1.377538352414097e-05 0.1280230438022905 0.04267011543928714 7.155875001287826e-11 10.145337254287599 0.549312065871088 VALVLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VALVLLR 7 0 Q4KMP7 Q4KMP7 TBC1D10B TBC1 domain family member 10B 0 135099000.0 75969000.0 28660000.0 30470000.0 False True 63171589.49733421 28505602.89143541 36841136.12263782 1.0 0.4512408682171647 0.5831915330259735 25.912772537380807 -10.07632521639341 7.576866044289311 1.0000000484387128 0.5172162006217036 0.9469476035154604 0.053868633333766444 4.4081448756698194e-08 5.334030979750636e-09 0.05215808538663205 0.017386026648719265 8.388316019385112e-11 10.07632521639341 -0.4827838478170092 VALVLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VALVLLR 7 0 Q4KMP7 Q4KMP7 TBC1D10B TBC1 domain family member 10B 0 29457700.0 8822900.0 15380000.0 5254800.0 False True 11421417.97535976 14524089.479893431 4298480.318801182 1.0 1.2716537921322277 0.37635259720593367 23.445238437419 -6.825307293076336 1.3487388210365812 1.14568818521151 0.35448830154444333 0.8961602792275342 0.1207771838525251 0.18667429281651532 0.6657506019285433 0.07034120008603822 0.1619435540834797 1.4951773413995154e-07 6.825307293076336 -0.7911998836670666 down VALVTFNSAAHNKPSLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VALVTFNSAAHNKPSLIR 18 1 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 85302300.0 35715700.0 24976800.0 24609800.0 False True 46823628.57133076 21250358.79880388 22063413.96987084 1.0 0.4538383599731329 0.47120256680362993 25.48073340385199 -9.938245770873623 7.175667541564042 1.0000000129290427 0.462520463415988 0.9992178181151616 0.007088907753814075 1.4716732862158174e-09 2.138031255106944e-10 0.006863805622886453 0.0022879351394431424 1.1528006936544471e-10 9.938245770873623 -0.5374795495130547 VALVTFNSAAHNKPSLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VALVTFNSAAHNKPSLIR 18 1 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 58726900.0 15109000.0 11636600.0 31981300.0 False True 14629373.065248482 16283155.064067336 23604438.111565597 1.0 1.1130453090124108 1.6134962179368466 23.802364609010073 -6.942552835689404 0.6353762306033243 0.9945350020107186 1.75922746620229 0.9984794555018108 0.010395255704400959 0.08662118809757545 0.04945047133075094 0.010326630108235089 0.042612031567480384 1.141424431992273e-07 6.942552835689404 0.7646924641915713 VALVTFNSAAHNKPSLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VALVTFNSAAHNKPSLIR 18 1 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 108799100.0 35715700.0 20557300.0 52526100.0 False True 48920759.4705009 19649010.512099687 40120516.98898645 1.0 0.4016497438873162 0.8201123086238884 25.54394346537488 -10.22730055693793 5.6970195741909935 1.0000154169532613 0.6108810262556343 0.5355094903613953 0.1708366266768617 3.345375544722257e-05 4.537584011905858e-06 0.16541839730785823 0.0551372841701402 5.925151278665809e-11 10.22730055693793 -0.389134390697627 VALVTFNSAAHNKPSLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VALVTFNSAAHNKPSLIR 18 1 Q86VP6;Q86VP6-2;A0A0C4DGH5 Q86VP6 CAND1 Cullin-associated NEDD8-dissociated protein 1 0 36255300.0 15109000.0 10107000.0 11039300.0 False True 12563802.942189878 10052551.584917575 13347566.590043833 1.0 0.8001201253452173 1.0623826759668475 23.58276988444435 -6.703013575335174 1.8203212616785962 0.8762472069001296 1.0616422098301472 0.43175330115013755 0.0843266812463477 0.38931162629399907 2.5100485399000885 0.036929897329211196 0.09461525170897012 1.9814650874793014e-07 6.703013575335174 0.18539500293001765 VALVYGQMNEPPGAR ddPTM_RPMI8226_Bortezomib_1h_R1 2 VALVYGQMNEPPGAR 15 0 P06576;H0YH81;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 58341300.0 13654100.0 21420600.0 23266600.0 False True 17900657.32649247 18224729.97684482 20859195.420986596 1.0 1.0181039525220525 1.1652753885252902 24.09350922959264 -6.929797790736683 0.7484421131894731 0.9977451777977971 1.1953347382957988 0.9964985244859343 0.004379668100824014 0.09274271014068085 0.07819321438785004 0.003985319500947484 0.013331284166049201 1.175444719353361e-07 6.929797790736683 0.1975895604980017 VALVYGQMNEPPGAR ddPTM_RPMI8226_Bortezomib_2h_R1 2 VALVYGQMNEPPGAR 15 0 P06576;H0YH81;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 40701600.0 13958700.0 3693200.0 23049700.0 False True 13515588.709106084 5167914.019783568 17012292.093822118 1.0 0.38236691948917495 1.2587163208333012 23.68812101805308 -6.717298807453636 1.7688312836332565 0.6231699582563553 1.2571688947723294 0.4998671906908865 0.25999103898862874 0.36057426785607327 2.203238458579635 0.116770430710341 0.2940954424353074 1.9173490938364285e-07 6.717298807453636 0.633998936515974 VALVYGQMNEPPGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VALVYGQMNEPPGAR 15 0 P06576;H0YH81;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 10134800.0 1852000.0 8282800.0 0.0 False True 2809619.3993360214 6804669.62618822 0.0 1.0 2.421918651258004 0.0 21.42194328059612 -6.749312051523727 1.6636848186503495 1.8384435768955327 3.983780020177145e-09 0.6384661320152161 0.5975084987169397 0.3028721977500196 1.6511178096532058 0.28430948582506277 0.687688138691435 1.7810985434029853e-07 6.749312051523727 -1.8384435729117528 VALVYGQMNEPPGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VALVYGQMNEPPGAR 15 0 P06576;H0YH81;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 69649300.0 13654100.0 25637400.0 30357800.0 False True 18702389.758178227 24504654.896455504 23187912.878516637 1.0 1.3102419109696957 1.2398368966926792 24.156719291115532 -10.038472581722406 4.295701048200222 0.9999802763515436 1.2750394038440365 0.9531571672041048 0.02874272691773169 4125363.3885201877 3213472.2025864576 686.2122658114914 0.009839400470580116 9.152240382208626e-11 10.038472581722406 0.27505912749249284 VALVYGQMNEPPGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VALVYGQMNEPPGAR 15 0 P06576;H0YH81;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 26934700.0 13958700.0 6634000.0 6342000.0 False True 11607277.525259495 6598261.325254097 7668082.877905113 1.0 0.568458995737382 0.6606271678451734 23.468526293487358 -9.977692350100895 5.956579927859252 1.0000003137029603 0.6145430817912159 0.9588815717544733 0.037627498698445914 1.567562844323287e-07 2.6886659960728732e-08 0.03643269881273722 0.01214422298483867 1.0527073371785238e-10 9.977692350100895 -0.3854572319117444 VALVYGQMNEPPGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VALVYGQMNEPPGAR 15 0 P06576;H0YH81;F8W0P7 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 28149600.0 5573600.0 10402000.0 12174000.0 False True 7215135.072081186 9823119.555907112 9958456.915788542 1.0 1.36146024402474 1.380217669704145 22.78259497249493 -11.907734682884414 0.4629877061059277 7.792172872114582e-15 1.379993320202922 0.9998462853219264 0.0021694592453840025 5.675293882965809 0.2305569972643629 5.57995695638823 0.0041132539000956645 1.2367027232471222e-12 11.907734682884414 1.3799933202029142 VAMFLTDSNNIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAMFLTDSNNIK 12 0 Q15046;Q15046-2 Q15046 KARS Lysine--tRNA ligase 0 23070700.0 6080800.0 1983900.0 15006000.0 False True 5887768.332461643 2776081.6159018283 11075478.429649608 1.0 0.471499804195109 1.881099561711018 22.489289475742186 -6.805142132478363 1.4346935296771808 0.710268939746836 1.903147464361158 0.8467906878991553 0.22758582600153432 0.21350920818325672 0.8669957935758174 0.12475958242438874 0.28930238713490886 1.566238400050549e-07 6.805142132478363 1.1928785246143219 VAMHILNNGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAMHILNNGR 10 0 P49748-2;P49748;P49748-3;J3KSR4 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 11599700.0 4489200.0 3090600.0 4019900.0 False True 5885384.673474644 2629494.527064442 3603959.3096036427 1.0 0.44678379969206455 0.6123574769626602 22.48870528337758 -10.883248669662427 11.191652151226041 1.0232195681868828 0.5295706383274218 0.9149897589161596 0.06759517069153603 0.030263474151619844 0.00031570802687969654 0.05057709994197413 0.02181624753103056 1.3084325221783217e-11 10.883248669662427 -0.49364892985946096 VAMHILNNGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAMHILNNGR 10 0 P49748-2;P49748;P49748-3;J3KSR4 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 8957300.0 2837300.0 1317500.0 4802500.0 False True 2747231.464559499 1843584.620671734 3544581.178088249 1.0 0.6710700006369288 1.2902375441657952 21.389547037329567 -6.762360876368686 1.603560330439167 0.8095092457905886 1.292772394641177 0.7006110379330376 0.1383989926286252 0.2789318207753807 1.4141271089466545 0.06808062017956427 0.16323086567567652 1.7283795678574382e-07 6.762360876368686 0.4832631488505885 VAMHILNNGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAMHILNNGR 10 0 P49748-2;P49748;P49748-3;J3KSR4 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 12151700.0 4489200.0 2788600.0 4873900.0 False True 6148978.556068423 2665390.4313329686 3722785.201121363 1.0 0.43346881226354195 0.6054314821845245 22.551915344900472 -10.349149980362254 5.011191261591705 1.0002631506926738 0.5194501472239396 0.9123753545827515 0.07020346601917446 0.00020650922143216472 2.682137587790534e-05 0.0680107994981292 0.022658071228144252 4.475587164182566e-11 10.349149980362254 -0.48081300346873423 VAMHILNNGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAMHILNNGR 10 0 P49748-2;P49748;P49748-3;J3KSR4 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 6565000.0 2837300.0 2426000.0 1301700.0 False True 2359340.663702118 2412930.6564767044 1573879.4516192183 1.0 1.0227139698811007 0.6670844426296595 21.169952312763844 -6.891661795409362 1.0124641583950729 1.0183540345849809 0.6354780184661725 0.9819420356132726 0.021844307212865934 0.11780658825560408 0.2140372950354268 0.016401951820685427 0.0411441592630767 1.283329579923205e-07 6.891661795409362 -0.3828760161188084 VAMHILNNGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAMHILNNGR 10 0 P49748-2;P49748;P49748-3;J3KSR4 P49748-2 ACADVL Very long-chain specific acyl-CoA dehydrogenase, mitochondrial 0 6438500.0 1715600.0 3265300.0 1457600.0 False True 2220878.01953181 3083583.1845706115 1192331.7562389823 1.0 1.388452295646868 0.5368740406960042 21.082698725176527 -6.782686779498768 1.525457789794534 1.2191832527164104 0.5295576145065062 0.7767677919217648 0.16446868576170168 0.2464202107274137 1.1327791934782803 0.08490477508841524 0.19988979682027616 1.6493515027772763e-07 6.782686779498768 -0.6896256382099042 VANDNAPEHALRPGFLSTFALATDQGSK(ub)LGLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VANDNAPEHALRPGFLSTFALATDQGSKLGLSK 33 2 Q9UHA4 Q9UHA4 LAMTOR3 Ragulator complex protein LAMTOR3 1 23278400.0 6408500.0 8046200.0 8823700.0 True False 8295929.580420609 7598421.89682176 7217877.138807567 1.0 0.9159216966782058 0.8700504348352504 22.983972217283274 -13.999999995462005 0.07356934684311667 1.4733126177783702 0.7151429208393192 0.9999117919305751 0.0005053515835709245 12.323521333832504 0.07439345332270438 0.9804981004866575 0.14191040853971104 1.0000000104491193e-14 13.999999995462005 -0.758169696939051 VANHQK(ub)DLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VANHQKDLFR 10 1 Q9UBM7;H0YE57 Q9UBM7 DHCR7 7-dehydrocholesterol reductase 1 21631980.0 526420.0 957560.0 20148000.0 True False 690141.717858531 814695.780539646 18063278.23326307 1.0 1.180476066665842 26.173288421561235 19.396533118440942 -6.908481906140423 0.9059953206225227 0.18852600156435126 29.300629075653877 0.9903363050826925 1.1623960626921697 0.10543097098293233 0.1442701610196481 0.9445823563398228 2.5808970500528488 1.2345767498399066e-07 6.908481906140423 29.112103074089525 up VANHQK(ub)DLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VANHQKDLFR 10 1 Q9UBM7;H0YE57 Q9UBM7 DHCR7 7-dehydrocholesterol reductase 1 82831430.0 925430.0 47600000.0 34306000.0 True False 1403944.9679954266 39105408.099502556 27525404.06314605 1.0 27.85394655129384 19.605757127679464 20.42105495514035 -9.334939702323226 10.262671338807085 0.9999257345897767 23.729851839486702 0.9101160632088262 3.367309231885856 0.0 0.0 3.2603831440326707 1.0867943813442233 4.6244522308290617e-10 9.334939702323226 22.729926104896926 VANHQK(ub)DLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VANHQKDLFR 10 1 Q9UBM7;H0YE57 Q9UBM7 DHCR7 7-dehydrocholesterol reductase 1 32412600.0 526420.0 665180.0 31221000.0 True False 721051.6999655917 635790.1481438943 23847242.81667868 1.0 0.8817538994419318 33.07286123563215 19.459743179963834 -6.904972706482922 0.9296743741265536 6.835333322409011e-13 36.80971884840381 0.9894301875745283 1.5572815370126571 0.1061124548547764 0.15514468980569726 1.2530594801124462 3.348097670329691 1.2445928265532738e-07 6.904972706482922 36.80971884840313 up VANHQK(ub)DLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VANHQKDLFR 10 1 Q9UBM7;H0YE57 Q9UBM7 DHCR7 7-dehydrocholesterol reductase 1 40294770.0 516870.0 1798900.0 37979000.0 True False 429800.3062234219 1789208.9686463075 45920233.304944545 1.0 4.162884350566814 106.84085757973834 18.713306985091887 -6.909001777052698 0.9047552785010027 1.3417949618495845e-16 119.72648836646852 0.9920107949339053 4.394511891138569 0.09984423281651762 0.13617260036368925 3.672340136866513 10.04002219194786 1.2330997876023156e-07 6.909001777052698 119.72648836646852 up VANHQK(ub)DLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VANHQKDLFR 10 1 Q9UBM7;H0YE57 Q9UBM7 DHCR7 7-dehydrocholesterol reductase 1 58459430.0 925430.0 27881000.0 29653000.0 True False 1197987.377952507 26329397.840631276 24256458.265473753 1.0 21.978026083739824 20.247674317679976 20.192181277232798 -9.628677345803753 7.133144846288596 0.9999999985725584 21.11285020071537 0.9944794968728298 0.7064131504148654 3.387254771867839e-08 0.0 0.6839815866697889 0.22799386392195006 2.3513791027113964e-10 9.628677345803753 20.112850202142813 VANLLLCMYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VANLLLCMYAK 11 0 Q9Y2Q5;Q9Y2Q5-2 Q9Y2Q5 LAMTOR2 Ragulator complex protein LAMTOR2 0 45419000.0 11501000.0 19559000.0 14359000.0 False True 17447857.83572545 16068543.634835491 11520937.356226739 1.0 0.9209465016349608 0.6603066957960297 24.05654658434356 -6.949312148469571 0.5663539383133105 1.0033021402972266 0.5653582408058899 0.9991461240380042 0.004240970426916769 0.0837633189846452 0.037115946876784094 0.004511961270245847 0.0216973591071016 1.1237969563422996e-07 6.949312148469571 -0.4379438994913367 VANLLLCMYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VANLLLCMYAK 11 0 Q9Y2Q5;Q9Y2Q5-2 Q9Y2Q5 LAMTOR2 Ragulator complex protein LAMTOR2 0 39319000.0 11501000.0 15300000.0 12518000.0 False True 14888271.21860301 14448541.550219087 10239852.445526617 1.0 0.970464692513495 0.6877798164189702 23.82767290643601 -6.926921305504793 0.7716439596484668 1.0048250133851158 0.6340481599904179 0.9958977950289454 0.009014046368335521 0.09426829006238106 0.08574472299057675 0.008066539648126671 0.026024543109969343 1.183255943190855e-07 6.926921305504793 -0.3707768533946979 VANQIK(ub)EEEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VANQIKEEEEK 11 1 Q9Y6Y8;Q9Y6Y8-2 Q9Y6Y8 SEC23IP SEC23-interacting protein 1 5851900.0 1484500.0 1668200.0 2699200.0 True False 2252095.031487212 1370496.676293908 2165701.9368986147 1.0 0.6085430042394239 0.9616387881591542 21.102836275322538 -10.334863855622096 8.220356609254061 1.0000007321473798 0.7850908961992891 0.33062352064405265 0.14415075015522746 1.934247436915431e-06 1.5661220844507726e-07 0.13957383992340097 0.04652445455787518 4.625259931803151e-11 10.334863855622096 -0.21490983594809077 VANQIK(ub)EEEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VANQIKEEEEK 11 1 Q9Y6Y8;Q9Y6Y8-2 Q9Y6Y8 SEC23IP SEC23-interacting protein 1 2121500.0 798820.0 575120.0 747560.0 True False 1094165.3412988007 549709.2967324879 571001.7244814811 1.0 0.5024005751086665 0.5218605478799834 20.06139933217863 -10.499248428517157 9.618848637372514 1.0000074413210334 0.5121305615065247 0.9988081521962034 0.00794450061636342 1.2677959870194681e-06 6.600758874172435e-08 0.00769234681088962 0.002564076548425836 3.1677549008071823e-11 10.499248428517157 -0.48787687981450867 VANQIK(ub)EEEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VANQIKEEEEK 11 1 Q9Y6Y8;Q9Y6Y8-2 Q9Y6Y8 SEC23IP SEC23-interacting protein 1 2376790.0 654770.0 1240100.0 481920.0 True False 544470.2662292445 1233419.3351594221 582687.243853679 1.0 2.265356644177336 1.0701911196898006 19.05449373929286 -6.632746833130683 2.0701437753727188 1.83197785306168 1.0750274880749093 0.1274383581866282 0.5423986200066632 0.5520155791553147 4.511607799342552 0.21401233052510837 0.6008951048497105 2.3294487867696968e-07 6.632746833130683 -0.7569503649867706 VANVPNTSLLVNIPQPTPASLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VANVPNTSLLVNIPQPTPASLK 22 0 Q86YP4-2;Q86YP4;Q86YP4-3 Q86YP4-2 GATAD2A Transcriptional repressor p66-alpha 0 2348220.0 497860.0 1107900.0 742460.0 False True 652699.2812830976 942605.6385603761 665637.3613792186 1.0 1.4441652773193976 1.0198224212392069 19.316058925122423 -10.509453209549422 3.158117326563405 0.9934512483078726 1.2319938490718212 0.2849620185452255 0.17323724672498728 63234325.89215107 84202141.75926793 3629379.2401596447 0.06339834540114307 3.0941886622678096e-11 10.509453209549422 0.23854260076394862 VANVPNTSLLVNIPQPTPASLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VANVPNTSLLVNIPQPTPASLK 22 0 Q86YP4-2;Q86YP4;Q86YP4-3 Q86YP4-2 GATAD2A Transcriptional repressor p66-alpha 0 4318030.0 497860.0 813870.0 3006300.0 False True 681932.2961606121 777910.5322918169 2296273.8566920045 1.0 1.1407445235715885 3.3673047450903755 19.379268986645314 -6.919788744149859 0.8262918185725928 0.9504971825662457 3.72461900790917 0.994122027379038 0.08313164446739245 0.09829631247868684 0.10625953461330474 0.07154633282523433 0.21388446944940384 1.2028493998644323e-07 6.919788744149859 2.7741218253429243 up VANVSLLALYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VANVSLLALYK 11 0 P62266 P62266 RPS23 40S ribosomal protein S23 0 294599000.0 94863000.0 109350000.0 90386000.0 False True 124366311.65459886 93035406.24296163 81033723.76373404 1.0 0.7480756243808838 0.6515729435539431 26.890020500267514 -13.999999999999998 0.1329315826326676 2.1980726507749044 0.5213275888276727 0.9996325513973692 0.0028156486575072882 11.93330126523653 0.11366089073864882 3.7262662225649885 0.11597244954984472 1.0000000000000041e-14 13.999999999999998 -1.6767450619472317 VANVSLLALYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VANVSLLALYK 11 0 P62266 P62266 RPS23 40S ribosomal protein S23 0 265938000.0 130370000.0 67393000.0 68175000.0 False True 126231475.7109302 94303376.34985214 50317922.293839894 1.0 0.7470670513731985 0.3986162881361526 26.911496449055992 -6.966632779911075 0.32882758007302565 1.0430369419670562 0.09125935322662006 0.9999429523662217 0.0018621348256545006 0.07741119030662288 0.012929492066756481 0.005105901767328948 0.030421538674758865 1.0798594173806545e-07 6.966632779911075 -0.9517775887404362 down VANVSLLALYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VANVSLLALYK 11 0 P62266 P62266 RPS23 40S ribosomal protein S23 0 527110000.0 124430000.0 213900000.0 188780000.0 False True 188769407.05150142 175727873.79167193 151467550.25478664 1.0 0.9309128875089838 0.8023945861813412 27.492049732107073 -6.961436611842858 0.4146915591133192 1.0060160475530584 0.7224853483969869 0.9998198179660492 0.0010990653827374485 0.07919189404221244 0.01926429783402899 0.001657712149851069 0.01071459454014391 1.0928571252871114e-07 6.961436611842858 -0.28353069915607154 VANVSLLALYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VANVSLLALYK 11 0 P62266 P62266 RPS23 40S ribosomal protein S23 0 332523000.0 94863000.0 104780000.0 132880000.0 False True 129936414.67618257 100150473.13887545 101496480.74950401 1.0 0.7707652499760185 0.781124221431272 26.953230561790406 -10.487937676286569 7.0966584846507805 1.0000520500504055 0.7759447357058187 0.9983993759365418 0.004229032387571222 3.483540048958674e-06 2.513560668734568e-07 0.004095691270325646 0.0013649143339695966 3.251339525980494e-11 10.487937676286569 -0.22410731434458686 VANVSLLALYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VANVSLLALYK 11 0 P62266 P62266 RPS23 40S ribosomal protein S23 0 231055000.0 130370000.0 49026000.0 51659000.0 False True 108408431.37026238 48761887.20710097 62460658.055771075 1.0 0.44979792245639755 0.5761605187555985 26.69190172449027 -9.945956132169115 7.014721021088981 1.0000000196663534 0.5129792206061565 0.9519369263221136 0.051587313917728486 1.586492468079925e-08 2.4404286933026544e-09 0.04994920340832926 0.016649733973244065 1.132514752109125e-10 9.945956132169115 -0.4870207990601969 VANVSLLALYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VANVSLLALYK 11 0 P62266 P62266 RPS23 40S ribosomal protein S23 0 485230000.0 124430000.0 209210000.0 151590000.0 False True 161077087.88199052 197567279.58962974 124002175.44474976 1.0 1.2265386852186757 0.7698312471081992 27.263176054199523 -6.771819339699513 1.5675702189700063 1.1296262736192884 0.7670856881295175 0.7375338227161063 0.09552206549907791 0.26344815118237286 1.277857198630762 0.048025856725517846 0.11412796438197477 1.6911442772032473e-07 6.771819339699513 -0.36254058548977086 VANVSLLALYK(ub)GK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VANVSLLALYKGK 13 1 P62266 P62266 RPS23 40S ribosomal protein S23 1 13012900.0 2839400.0 3603900.0 6569600.0 True False 3722480.8967887107 3066212.167892171 5889840.812053053 1.0 0.8237012500285265 1.5822353358842132 21.827833014456893 -6.845496425592525 1.2565739947407055 0.9061662674743292 1.610032881055176 0.9335017630423003 0.08358028097675686 0.1624787768518167 0.49595352682384664 0.052101722537123724 0.1202734623790801 1.4272615770179365e-07 6.845496425592525 0.7038666135808469 VANVSLLALYK(ub)GK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VANVSLLALYKGK 13 1 P62266 P62266 RPS23 40S ribosomal protein S23 1 31201000.0 3558300.0 6495700.0 21147000.0 True False 3445343.714214949 9089466.88462801 15607966.303598562 1.0 2.638188708756776 4.530162328711222 21.716216485507108 -6.969237591584452 0.27578696008104264 0.5614704046219624 6.664203736166517 0.999975810839258 0.007094194232170032 0.07655086526240468 0.00991224425387873 0.03581732998568022 0.17460248973709677 1.0734020204430177e-07 6.969237591584452 6.102733331544554 VANVSLLALYK(ub)GK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VANVSLLALYKGK 13 1 P62266 P62266 RPS23 40S ribosomal protein S23 1 12371900.0 2839400.0 1997000.0 7535500.0 True False 3889202.911899816 1908765.9368041055 5755770.098494026 1.0 0.49078589624723457 1.479935665193262 21.891043075979784 -6.766790511006899 1.5869064891114686 0.7067342315616832 1.4848165993765214 0.7180919028820488 0.21443891997817982 0.27164092657093103 1.349544752675019 0.10654885982786243 0.25436741038744404 1.7108403677083825e-07 6.766790511006899 0.7780823678148382 VANVSLLALYK(ub)GK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VANVSLLALYKGK 13 1 P62266 P62266 RPS23 40S ribosomal protein S23 1 21746400.0 3558300.0 6752100.0 11436000.0 True False 2958884.1094178464 6715725.097113086 13827214.725910261 1.0 2.269681693763393 4.673118045380538 21.496621760941384 -6.9611064121581805 0.4195501630472521 0.8932479625576408 6.140148511660832 0.9998090568223367 0.02104748202309225 0.07930823678962344 0.019688345358386535 0.031081714648113663 0.20009269314405015 1.0936883545834655e-07 6.9611064121581805 5.2469005491031915 VANVSLLALYK(ub)GK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VANVSLLALYKGK 13 1 P62266 P62266 RPS23 40S ribosomal protein S23 1 31913800.0 4684800.0 0.0 27229000.0 True False 6064565.951213928 0.0 22273601.39313341 1.0 0.0 3.6727445248863955 22.531972962825012 -6.834161494861287 1.309188065972184 0.46700640287691875 3.7802640928703766 0.9139480547954484 0.4547928289579353 0.175731330853488 0.5875738637097544 0.2726255453969154 0.6274448180143779 1.4650029700089175e-07 6.834161494861287 3.313257689993458 VAPAEPQEAPDSTAAGGSASK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAPAEPQEAPDSTAAGGSASKR 22 1 Q3LXA3;H0YCY6;Q3LXA3-2;I3L252 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 1 18002400.0 2578800.0 5438400.0 9985200.0 True False 3912228.1355333324 4467875.029586864 8011620.843331363 1.0 1.1420282444693841 2.047840914635001 21.899559070597462 -6.934557212642612 0.7083885720979849 0.9882760522992146 2.2573942050612765 0.9973605362509286 0.023844327502817605 0.09033954243342214 0.06658807007665798 0.022345693073001695 0.08000641588158228 1.1626333791064792e-07 6.934557212642612 1.2691181527620619 up VAPAEPQEAPDSTAAGGSASK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAPAEPQEAPDSTAAGGSASKR 22 1 Q3LXA3;H0YCY6;Q3LXA3-2;I3L252 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 1 7189000.0 1139800.0 2189000.0 3860200.0 True False 947794.201701504 2177207.4225175222 4667349.972451801 1.0 2.297130979076412 4.9244339795209315 19.854214309492498 -6.959796515026342 0.43829196889610333 0.904368253140678 6.419341517984906 0.9997625784785282 0.025154852863222298 0.07977389091725097 0.02140048501630952 0.034567365507890635 0.21776026314138372 1.0969920620200663e-07 6.959796515026342 5.514973264844228 VAPAEPQEAPDSTAAGGSASK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAPAEPQEAPDSTAAGGSASKR 22 1 Q3LXA3;H0YCY6;Q3LXA3-2;I3L252 Q3LXA3 DAK;TKFC Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing);ATP-dependent dihydroxyacetone kinase;FAD-AMP lyase (cyclizing) 1 20129900.0 2578800.0 4686100.0 12865000.0 True False 3338307.4357476304 4425314.415587041 10523702.006047292 1.0 1.3256161994546705 3.1524064840033095 21.67068539268991 -6.937272407986091 0.6844655156524798 0.9782080014903595 3.6078713579925745 0.9977844118409828 0.0445884681761365 0.0890332532132519 0.06044259284424594 0.04255408825389757 0.1592094327736519 1.155387306759375e-07 6.937272407986091 2.629663356502215 up VAPAPAVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAPAPAVVK 9 0 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 0 6240190.0 1876500.0 745690.0 3618000.0 False True 1816931.5346441695 1043447.9057219782 2670337.2623265563 1.0 0.5742912629486221 1.4696961395683623 20.793072626490968 -6.7774081457899875 1.5458242045432762 0.7581409189040246 1.476238365108768 0.7581517907860016 0.1798414853329153 0.2546273943959465 1.2015943554483952 0.09164637742450707 0.21673321840128715 1.6695208771016626e-07 6.7774081457899875 0.7180974462047435 VAPEEHPVLLTEAPLNPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAPEEHPVLLTEAPLNPK 18 0 K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65 K7EM38;P60709;P63261 ACTG1;ACTB Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 867487000.0 12946000.0 554690000.0 299851000.0 False True 16972331.36924233 471932414.164685 268825294.8938935 1.0 27.80598633726492 15.839031718474764 24.016681415528577 -9.438659697252174 11.102546629712272 1.0000008568191563 21.82250902764957 0.8014613673685078 4.885488765179736 0.0 0.0 4.7303537334799115 1.5767847188020419 3.6420030297755727e-10 9.438659697252174 20.822508170830414 VAPEEHPVLLTEAPLNPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAPEEHPVLLTEAPLNPK 18 0 K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65 K7EM38;P60709;P63261 ACTG1;ACTB Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 719633900.0 226233100.0 93232800.0 400168000.0 False True 219051454.0742379 130461143.24262904 295351996.0173278 1.0 0.5955730528883636 1.3483224627088353 27.706694550471607 -6.760758112793455 1.6094582155719073 0.765306976891212 1.351191040166589 0.6941044081230503 0.17012303799773745 0.2816509339177239 1.438067004882353 0.08339000408403727 0.20026224674117915 1.7347699363889788e-07 6.760758112793455 0.585884063275377 VAPEEHPVLLTEAPLNPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAPEEHPVLLTEAPLNPK 18 0 K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65 K7EM38;P60709;P63261 ACTG1;ACTB Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 2699730000.0 18864000.0 2655810000.0 25056000.0 False True 28618067.143128894 2181859955.5617614 20103670.617565077 1.0 76.24064702376725 0.7024817754818883 24.770422900315648 -3.0034556386773996 7.733651541965328e-16 9.981502108985637 59.46731381155227 0.0 36.59883996144908 0.0 0.29460029845987923 473329636.4309587 473329609.0440738 0.0009920746702453392 3.0034556386773996 49.485811702566636 VAPEEHPVLLTEAPLNPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAPEEHPVLLTEAPLNPK 18 0 K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65 K7EM38;P60709;P63261 ACTG1;ACTB Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 937081000.0 12946000.0 491266000.0 432869000.0 False True 17732486.05249526 469560243.7205839 330634257.4168948 1.0 26.480226310653652 18.64567982391668 24.07989147705147 -9.967323509668805 11.620033370648116 1.0000000010937269 22.562953215726175 0.9099110640214297 3.1984402097700353 0.0 0.0 3.096876416569879 1.0322921388566262 1.0781433048747141e-10 9.967323509668805 21.562953214632447 VAPEEHPVLLTEAPLNPK(ub)ANR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAPEEHPVLLTEAPLNPKANR 21 1 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 159226600.0 35471500.0 47689500.0 76065600.0 True False 46503480.00649458 40574412.492215045 68195061.3847575 1.0 0.8725027134861414 1.4664507124033195 25.470835346029062 -6.8505589713695185 1.2325001895470735 0.9319326613928712 1.4904368337567133 0.9410989751048111 0.06196028952931044 0.15684521528610004 0.4582222600393029 0.039333474422083015 0.0910469886332348 1.4107206664943462e-07 6.8505589713695185 0.5585041723638421 VAPEEHPVLLTEAPLNPK(ub)ANR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAPEEHPVLLTEAPLNPKANR 21 1 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 283131800.0 52658300.0 52514500.0 177959000.0 True False 50986691.0901961 73483813.70949973 131346199.24443652 1.0 1.4412351956612743 2.5760879248289212 25.603617377885723 -6.954850413165737 0.5027842096528814 0.9778107048035799 3.0886918948660638 0.9995289950164707 0.01440795810297785 0.08159457147742911 0.028339581195015923 0.016809645187144992 0.09362506652201134 1.109556921260859e-07 6.954850413165737 2.110881190062484 up VAPEEHPVLLTEAPLNPK(ub)ANR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAPEEHPVLLTEAPLNPKANR 21 1 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 1318337300.0 110125300.0 181841000.0 1026371000.0 True False 167068131.33785033 149390052.81978235 823508321.9756092 1.0 0.8941864113969239 4.929176590299471 27.315861321069782 -6.900880396613413 0.955709684387091 0.8362684018570826 5.360334768871238 0.9869985622186208 0.21409905386635045 0.11075933408307438 0.17379793188983816 0.16773886467277146 0.43837558524064985 1.2563759181826422e-07 6.900880396613413 4.524066367014155 up VAPEEHPVLLTEAPLNPK(ub)ANR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAPEEHPVLLTEAPLNPKANR 21 1 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 186684800.0 35471500.0 48218000.0 102995300.0 True False 48586272.131244026 46087569.32439675 78669931.39478764 1.0 0.9485718352686612 1.6191802322738387 25.534045407551954 -6.888392986326313 1.0318629124105998 0.9625669041888074 1.675070631411286 0.9798488539902678 0.04325789836586426 0.12045586165654774 0.22955185904048464 0.03200836726517792 0.07934789431354172 1.2930252734433793e-07 6.888392986326313 0.7125037272224786 VAPEEHPVLLTEAPLNPK(ub)ANR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAPEEHPVLLTEAPLNPKANR 21 1 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 267028600.0 52658300.0 76614900.0 137755400.0 True False 43787709.60822796 76202160.32683304 166559417.230995 1.0 1.7402636723550897 3.8037937750390474 25.38402265332 -6.953089062694281 0.5238335085728256 0.965945493980051 4.670805570456583 0.9994219412474253 0.02852387849029645 0.08226851915338869 0.031008415723363904 0.032120228947392734 0.17051690819008 1.114066043702475e-07 6.953089062694281 3.704860076476532 VAPEEHPVLLTEAPLNPK(ub)ANR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAPEEHPVLLTEAPLNPKANR 21 1 P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65 P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 1 1270828300.0 110125300.0 181092000.0 979611000.0 True False 142559371.74419814 171014071.00733808 801331849.6576736 1.0 1.1995989384282482 5.621039429772081 27.08698764316223 -6.916345077733167 0.8514023398779328 0.8890132327659169 6.277340968645893 0.99310380715606 0.17712227208913525 0.10037002718036171 0.11711349870716432 0.14972595650917195 0.43395434709703645 1.2124251099923256e-07 6.916345077733167 5.388327735879976 up VAPEMFFSPQVFEQPGPSIPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAPEMFFSPQVFEQPGPSIPR 21 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 3113350.0 300170.0 2003200.0 809980.0 False True 393525.7768504146 1704330.3684124404 726171.0394767915 1.0 4.330924347708698 1.8452947232293266 18.58609861313344 -6.571404247438975 2.3009537938460833 3.2799119611277883 1.8505860216867387 0.0 1.450202822361346 0.7256114767119066 7.213626221088715 0.532132822308093 1.6249166614674289 2.682846052063402e-07 6.571404247438975 -1.4293259394410496 VAPEMFFSPQVFEQPGPSIPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAPEMFFSPQVFEQPGPSIPR 21 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 7255000.0 1665000.0 1530900.0 4059100.0 False True 1612145.486374922 2142196.353538036 2995899.939610205 1.0 1.3287860007938792 1.8583310035788394 20.620550513562616 -6.964048284407651 0.3740328930099632 0.9610946267839899 2.2445722546923665 0.9998921536315849 0.0036720241723343173 0.07828549784941244 0.016008308735263557 0.006939950076785957 0.0448787330857374 1.0863048426633422e-07 6.964048284407651 1.2834776279083766 VAPEMFFSPQVFEQPGPSIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAPEMFFSPQVFEQPGPSIPR 21 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 5264570.0 300170.0 1936900.0 3027500.0 False True 411150.96078923985 1851321.3535282277 2312466.8533197097 1.0 4.502777641512636 5.624374193071882 18.649308674656332 -9.26002188381876 0.38567384686393275 2.8633635665036535e-23 5.827969177606603 0.9980246552446413 0.08753650834539163 0.649001785097922 0.15008639058944861 1.2677188892978948 0.29316106097641004 5.495131835451784e-10 9.26002188381876 5.827969177606603 VAPSAVLGPNVSIGK(ub)GVTVGEGVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAPSAVLGPNVSIGKGVTVGEGVR 24 1 Q96IJ6;Q96IJ6-2;A0A087WUI8;A0A0U1RRC2 Q96IJ6 GMPPA Mannose-1-phosphate guanyltransferase alpha 1 19009900.0 4952600.0 9385400.0 4671900.0 True False 6492906.561046626 7985134.904002657 4188496.60402927 1.0 1.2298243981991772 0.6450880764490939 22.63043301711763 -6.800104894870728 1.4556823670016341 1.1267856424892915 0.6370128900396326 0.8324245652369393 0.09846389222971354 0.22060277710681397 0.9229014812784917 0.05321513822901194 0.12373995626159251 1.5845104404384716e-07 6.800104894870728 -0.4897727524496589 VAPSAVLGPNVSIGK(ub)GVTVGEGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAPSAVLGPNVSIGKGVTVGEGVR 24 1 Q96IJ6;Q96IJ6-2;A0A087WUI8;A0A0U1RRC2 Q96IJ6 GMPPA Mannose-1-phosphate guanyltransferase alpha 1 38671000.0 12648000.0 13766000.0 12257000.0 True False 12246496.16316518 19262835.588741645 9046523.997881869 1.0 1.5729262747560484 0.7387030443117161 23.545865703962363 -6.7218540575271835 1.7524323941694508 1.347861913174127 0.7398458448254451 0.5213651248867421 0.24103577351404942 0.3517187390985108 2.111872090618982 0.10916478437349679 0.2734705400131168 1.8973434067869228e-07 6.7218540575271835 -0.6080160683486818 VAPSAVLGPNVSIGK(ub)GVTVGEGVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAPSAVLGPNVSIGKGVTVGEGVR 24 1 Q96IJ6;Q96IJ6-2;A0A087WUI8;A0A0U1RRC2 Q96IJ6 GMPPA Mannose-1-phosphate guanyltransferase alpha 1 56866000.0 14036000.0 10433000.0 32397000.0 True False 21293638.16904988 8571149.636598947 25993718.749890488 1.0 0.4025216155432301 1.2207269863198922 24.34391912973805 -6.71092334620863 1.7916882014849385 0.6330275421980845 1.2188734368299483 0.4695184948539005 0.25173905061739665 0.3732598538211184 2.336241714094953 0.11178175948003041 0.283684622800565 1.9457034716327515e-07 6.71092334620863 0.5858458946318638 VAPSAVLGPNVSIGK(ub)GVTVGEGVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAPSAVLGPNVSIGKGVTVGEGVR 24 1 Q96IJ6;Q96IJ6-2;A0A087WUI8;A0A0U1RRC2 Q96IJ6 GMPPA Mannose-1-phosphate guanyltransferase alpha 1 20195800.0 4952600.0 9278100.0 5965100.0 True False 6783710.058982549 8868162.86342624 4556266.235090798 1.0 1.3072732747007065 0.671648138772925 22.69364307864052 -6.775260659922788 1.5543843473513927 1.175057088220733 0.6673455725611821 0.7502484151541132 0.1297057262051242 0.258007447601186 1.2309041141844728 0.0657474978731231 0.1557592101226417 1.6777967162819286e-07 6.775260659922788 -0.5077115156595509 VAPSAVLGPNVSIGK(ub)GVTVGEGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAPSAVLGPNVSIGKGVTVGEGVR 24 1 Q96IJ6;Q96IJ6-2;A0A087WUI8;A0A0U1RRC2 Q96IJ6 GMPPA Mannose-1-phosphate guanyltransferase alpha 1 36353800.0 12648000.0 15514000.0 8191800.0 True False 10517372.401404295 15430423.002712118 9904667.50539628 1.0 1.467136696676427 0.9417435389160314 23.32627097939664 -6.672170489287989 1.9298075349462622 1.2976184407945466 0.9438530293716748 0.28861555985955034 0.1983317603396612 0.45616903088753685 3.277293516478693 0.08267950736910555 0.22026527941602386 2.1273037747123033e-07 6.672170489287989 -0.35376541142287177 VAPSAVLGPNVSIGK(ub)GVTVGEGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAPSAVLGPNVSIGKGVTVGEGVR 24 1 Q96IJ6;Q96IJ6-2;A0A087WUI8;A0A0U1RRC2 Q96IJ6 GMPPA Mannose-1-phosphate guanyltransferase alpha 1 27226000.0 14036000.0 0.0 13190000.0 True False 18169878.69092358 0.0 10789555.340828888 1.0 0.0 0.5938154857477727 24.1150454518305 -10.063435369768332 6.52382004597571 1.0000005457995915 0.2969077428738838 0.6514731753598201 0.24242415690750654 1.924641285551002e-06 2.761134574824932e-07 0.23472636246924278 0.07824206020176075 8.641012437325652e-11 10.063435369768332 -0.7030928029257077 VAPYRPDQQVEEDDDFMDENQGK(ub)GIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAPYRPDQQVEEDDDFMDENQGKGIR 26 2 Q7KZ85 Q7KZ85 SUPT6H Transcription elongation factor SPT6 1 15507700.0 6187400.0 6090200.0 3230100.0 True False 5990984.37381153 8522048.619973429 2384039.9090771168 1.0 1.4224788596054387 0.39793792811386763 22.514361639873783 -6.794723848550617 1.477260648445009 1.2346892229266537 0.3855584398197496 0.8162809244422815 0.18019525709524437 0.22839763928467463 0.9844652235467536 0.0959840154018904 0.2239882243327719 1.6042651580299525e-07 6.794723848550617 -0.8491307831069042 down VAPYRPDQQVEEDDDFMDENQGK(ub)GIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAPYRPDQQVEEDDDFMDENQGKGIR 26 2 Q7KZ85 Q7KZ85 SUPT6H Transcription elongation factor SPT6 1 14286200.0 6187400.0 5565300.0 2533500.0 True False 5145097.2482960895 5535318.624274435 3063243.1364195226 1.0 1.0758433431180676 0.5953712803842497 22.29476691530806 -6.866520923240843 1.1522549474186896 1.0421169514794073 0.5690220468431653 0.961090518351595 0.04160212753910573 0.14023905249497962 0.3501671336946482 0.02807413609495719 0.06609786724800308 1.3598126492747282e-07 6.866520923240843 -0.47309490463624204 VAPYRPDQQVEEDDDFMDENQGK(ub)GIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAPYRPDQQVEEDDDFMDENQGKGIR 26 2 Q7KZ85 Q7KZ85 SUPT6H Transcription elongation factor SPT6 1 31535700.0 8182700.0 12294000.0 11059000.0 True False 10592666.455131104 11609828.092705462 9046375.474922407 1.0 1.0960250794153574 0.8540224987958843 23.336562463869708 -6.799022278284253 1.459745367257218 1.053046295650218 0.8507556049516135 0.8293492308440618 0.04110179048700767 0.22214507861404625 0.9346022325911738 0.02215130967034906 0.05155033924537676 1.588465261980309e-07 6.799022278284253 -0.2022906906986045 VAQAQAQHELEIKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAQAQAQHELEIKK 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 12109900.0 3120400.0 6366100.0 2623400.0 True False 4090874.617996581 5416302.694863447 2351955.7334297346 1.0 1.3239962601239454 0.5749273573633882 21.963977889789792 -6.789152733222647 1.4997139801076018 1.1812797207942167 0.5671447261205526 0.7985755626773927 0.1376626604028806 0.2366127219435782 1.051347200450515 0.0722551504403481 0.16927218683033796 1.6249771812575693e-07 6.789152733222647 -0.6141349946736642 VAQAQAQHELEIKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAQAQAQHELEIKK 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 19261500.0 6494000.0 7651800.0 5115700.0 True False 6287851.524635876 10707203.643609866 3775744.702289647 1.0 1.7028397699371427 0.6004824839607352 22.584135720890078 -6.734482003883671 1.7070777847665077 1.4208426605188589 0.6006046877364335 0.5798487292894114 0.2953668743063194 0.3278909936683293 1.873906262323716 0.13701071795605888 0.338246723413585 1.8429688555746481e-07 6.734482003883671 -0.8202379727824254 VAQAQAQHELEIKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAQAQAQHELEIKK 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 25785800.0 10655000.0 9254900.0 5875900.0 True False 16164413.984840857 7603290.786136261 4714525.7895015385 1.0 0.470372188763954 0.29166079227634645 23.94631787000595 -13.999999999999998 0.1517148469102995 3.567970557540123 0.09886712739314035 0.9995606168772209 0.006304672735864261 11.964555071924503 0.12275576302208167 9.053353441094663 0.17406829826312037 1.0000000000000041e-14 13.999999999999998 -3.4691034301469825 VAQAQAQHELEIKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAQAQAQHELEIKK 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 10958900.0 3120400.0 5668200.0 2170300.0 True False 4274096.205639284 5417760.181769166 1657719.838731551 1.0 1.2675803072988672 0.38785271996085147 22.027187951312683 -6.825106311778644 1.3496775270832109 1.1435302235525557 0.36646926935313295 0.8957094451257162 0.11891170314471579 0.1869364393141005 0.6676857477034835 0.0692082290434608 0.15933562690139372 1.49586943452619e-07 6.825106311778644 -0.7770609541994228 down VAQAQAQHELEIKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAQAQAQHELEIKK 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 17621800.0 6494000.0 8759200.0 2368600.0 True False 5400048.732979079 8712012.451034922 2863863.3088309807 1.0 1.6133210794615758 0.5303402710684529 22.364540996324354 -6.753062601933957 1.6385282653169113 1.359302098285153 0.5276733998380636 0.6620648956295275 0.25776964941670405 0.2947180375359222 1.5576808400662132 0.12422778254172585 0.30062604552520455 1.7657832712507297e-07 6.753062601933957 -0.8316286984470893 VAQAQAQHELEIKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAQAQAQHELEIKK 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 23384700.0 10655000.0 10106000.0 2623700.0 True False 13793107.541449882 9543592.216112038 2146213.5214353846 1.0 0.6919102303402218 0.15560043412884045 23.717444192098398 -7.312395002380463 0.5079046752754945 1.0104728369921898 7.33476558787255e-25 0.9983545647945441 0.01415261898842003 0.10139060871701755 0.05068379957386951 0.015417800339083736 0.057335813385454425 4.870852715668922e-08 7.312395002380463 -1.0104728369921898 down VAQGVSGAVQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAQGVSGAVQDK 12 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 15247960.0 992160.0 6714900.0 7540900.0 False True 1300731.3680911066 5713063.094475194 6760640.005420554 1.0 4.392192911330663 5.197568207601665 20.310891611364838 -9.526773516155956 0.42275166488186156 1.1072846474787967e-19 5.273260416357207 0.9983256534721268 0.07442667575796501 0.8592225787884887 0.1766889721902595 1.500628945966234 0.19175079652098423 2.9732161547485365e-10 9.526773516155956 5.273260416357207 VAQGVSGAVQDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAQGVSGAVQDK 12 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 13401200.0 4498500.0 1375700.0 7527000.0 False True 4355697.5798544055 1925024.184180728 5555452.894840241 1.0 0.4419554270902973 1.2754450447925587 22.054472359193888 -6.726283682032027 1.736743837330213 0.6627861354258541 1.274624290321401 0.541943854942684 0.23466561430452207 0.3432628967923833 2.0266150440496333 0.10715187247781047 0.2670198422141634 1.8780896441053669e-07 6.726283682032027 0.6118381548955468 VAQGVSGAVQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAQGVSGAVQDK 12 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 13695860.0 992160.0 6530100.0 6173600.0 False True 1358988.3641158424 6241578.5898470115 4715522.829283089 1.0 4.5928123850477425 3.4698772659109616 20.37410167288773 -10.114712556793524 12.297247479217724 0.9999720173379171 4.031344825484654 0.9066840492843927 0.45843634297409835 0.0 0.0 0.4438790802800996 0.14795969342669982 7.678695452243059e-11 10.114712556793524 3.031372808146737 VAQGVSGAVQDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAQGVSGAVQDK 12 0 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 5613840.0 4498500.0 590210.0 525130.0 False True 3740702.0673400685 587030.4215824873 634932.2550732127 1.0 0.1569305469975351 0.16973612002323915 21.834877634628164 -10.109555911273539 4.832970308220623 1.000041554291657 0.163333333504153 0.9998243376850691 0.005227853317993119 9581122.233384123 0.4431157946373611 4435.155951443579 0.001860772038095455 7.770412756988781e-11 10.109555911273539 -0.836708220787504 VAQGVSGAVQDK(ub)GSIHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAQGVSGAVQDKGSIHK 17 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 16810600.0 5013600.0 10296800.0 1500200.0 True False 6572878.151771464 8760557.576612046 1344973.694934545 1.0 1.3328343192016998 0.20462477226541306 22.64809380989386 -6.827695369076867 1.338188751450981 1.1781473135968472 0.17567223568190582 0.9011844991274726 0.14878674772466458 0.18367187458937212 0.6440713848962986 0.08731865407291292 0.2009721179801176 1.486978300574659e-07 6.827695369076867 -1.0024750779149414 down VAQGVSGAVQDK(ub)GSIHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAQGVSGAVQDKGSIHK 17 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 38499500.0 7749100.0 10451000.0 20299400.0 True False 7503109.06214289 14624138.801245013 14982378.171053538 1.0 1.949077199881239 1.9968226567100662 22.8390570981452 -11.005396325295155 0.5241465096253479 3.4503277483985996e-16 1.9937228511805907 0.9998255433628471 0.0060634475229423964 2.8466531286646077 0.25534179114560723 3.4413602638560263 0.009297308267395605 9.876513795767115e-12 11.005396325295155 1.9937228511805902 VAQGVSGAVQDK(ub)GSIHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAQGVSGAVQDKGSIHK 17 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 68160100.0 17447600.0 13445500.0 37267000.0 True False 26469284.790418543 11046045.47482901 29901161.115293678 1.0 0.41731560041348387 1.1296550455385714 24.657815877433347 -6.68924615240109 1.8688490524630124 0.6344446852428512 1.127188702262692 0.3670324389912033 0.24647096820689385 0.4182783159096884 2.8317324779541617 0.10552272484473037 0.27507477067274205 2.0452850674619944e-07 6.68924615240109 0.49274401701984083 VAQGVSGAVQDK(ub)GSIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAQGVSGAVQDKGSIHK 17 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 22807200.0 5013600.0 8818400.0 8975200.0 True False 6867263.407445564 8428773.929450836 6855442.610046261 1.0 1.2273846843143172 0.9982786742406754 22.711303871416753 -6.647924154275385 2.0159268440181752 1.1477950586410666 0.9992416938721507 0.1856042936820561 0.0971007705471465 0.5136945919398327 3.9991057734118876 0.03909550078625754 0.10754294670219135 2.24944741780901e-07 6.647924154275385 -0.1485533647689159 VAQGVSGAVQDK(ub)GSIHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAQGVSGAVQDKGSIHK 17 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 31384300.0 7749100.0 13909300.0 9725900.0 True False 6443719.993336654 13834367.840120116 11759540.722519303 1.0 2.1469536004708476 1.8249614717398726 22.619462373579477 -10.685502163425696 6.480697669627843 0.9909698947081448 1.98595753610536 0.9259345536723335 0.13145273609724067 0.016998641044300444 0.0008249156095586647 0.1261488888926566 0.04242618814316762 2.062993390541802e-11 10.685502163425696 0.9949876413972153 VAQGVSGAVQDK(ub)GSIHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAQGVSGAVQDKGSIHK 17 1 P12268;H0Y4R1 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 1 48358000.0 17447600.0 13579100.0 17331300.0 True False 22586262.14361344 12823411.148011759 14177181.23415524 1.0 0.5677526926091109 0.6276904582090854 24.428942199525796 -10.371160734043096 5.82994414141354 1.000086781858414 0.5977215754092177 0.983622880175834 0.024469490340415793 2.7606605818618734e-05 2.977760898042736e-06 0.023697560840241876 0.007897494048217454 4.2544092668380947e-11 10.371160734043096 -0.4023652064491964 VAQLEQVYIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAQLEQVYIR 10 0 P62318;P62318-2 P62318 SNRPD3 Small nuclear ribonucleoprotein Sm D3 0 23050000.0 3748300.0 8644700.0 10657000.0 False True 4914057.598588829 7354944.456776675 9554315.869162409 1.0 1.4967151502027156 1.9442824341143505 22.228483337221945 -6.972362445487156 0.19361278170173787 0.710618284518886 2.742652535450487 0.9999954233097538 0.0008250635609258524 0.07554331974036257 0.00620319497374581 0.015324580013493735 0.04831172215032109 1.0657063524257078e-07 6.972362445487156 2.032034250931601 VAQLEQVYIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAQLEQVYIR 10 0 P62318;P62318-2 P62318 SNRPD3 Small nuclear ribonucleoprotein Sm D3 0 19885500.0 7020200.0 2349300.0 10516000.0 False True 6797347.593663196 3287387.7414376526 7761544.126762313 1.0 0.483628017567074 1.1418489373705099 22.696540468633238 -6.697493720484535 1.8400967387303657 0.6785655791876206 1.1397835042931468 0.40558798218874215 0.21806882665836747 0.40074378326381827 2.6362931241601455 0.09461430697627832 0.24405248096666993 2.0068101065139531e-07 6.697493720484535 0.46121792510552617 VAQLEQVYIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAQLEQVYIR 10 0 P62318;P62318-2 P62318 SNRPD3 Small nuclear ribonucleoprotein Sm D3 0 23588500.0 3748300.0 9464200.0 10376000.0 False True 5134147.803998759 9046040.350075824 7925402.500427857 1.0 1.761936098339488 1.543664655360158 22.291693398744837 -10.36565338568078 5.25068438786828 0.9996951918802638 1.652800376849852 0.9226383352457267 0.0891089434534931 0.00031809904957989316 3.8430135302095845e-05 0.08631846093847367 0.02875978783277853 4.308703547934383e-11 10.36565338568078 0.6531051849695882 VAQLEQVYIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAQLEQVYIR 10 0 P62318;P62318-2 P62318 SNRPD3 Small nuclear ribonucleoprotein Sm D3 0 11395400.0 7020200.0 2646700.0 1728500.0 False True 5837607.347591585 2632441.701771184 2089921.358318985 1.0 0.4509453180089695 0.3580099232232914 22.476945744067514 -13.999999999999998 0.24991756485137365 4.81683383393236 0.32061275328591354 0.9995425339249018 0.0060590084275100545 13.994747584128188 0.15819151688650213 26.81440187114658 0.04290890834239161 1.0000000000000041e-14 13.999999999999998 -4.496221080646447 VAQNLVGPDNVHVALSLVEYKPELQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAQNLVGPDNVHVALSLVEYKPELQK 26 1 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 0 12081800.0 4457100.0 2643000.0 4981700.0 False True 4315611.800193195 3698363.6830629217 3676843.322203483 1.0 0.8569732066487905 0.8519865762807681 22.041133666048967 VAQNLVGPDNVHVALSLVEYKPELQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAQNLVGPDNVHVALSLVEYKPELQK 26 1 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 0 10657700.0 4457100.0 3156200.0 3044400.0 False True 3706276.1330090994 3139196.924143353 3680969.9642848214 1.0 0.8469948842140538 0.9931720768188602 21.821538941483244 -10.586281807735563 7.442955560082848 1.0000665810196507 0.9200834805182442 0.2849595574150403 0.059676588985719065 6.598767807020355e-05 3.6679429285918646e-06 0.057829675040378094 0.019260536275012903 2.5924965807202788e-11 10.586281807735563 -0.07998310050140656 VAQNLVGPDNVHVALSLVEYKPELQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAQNLVGPDNVHVALSLVEYKPELQK 26 1 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 0 28649600.0 9134800.0 9480800.0 10034000.0 False True 11825178.673827907 8953185.145706993 8207914.95753427 1.0 0.7571289527762183 0.6941049419997729 23.495358646499085 -13.999999999808225 0.18939436659295825 2.2992225205428602 0.6486143490544891 0.9994897503369196 0.0029789849230566004 12.340960889800575 0.13800879962879664 5.915888745710861 0.043552240102247085 1.0000000004415794e-14 13.999999999808225 -1.6506081714883711 VASEQSSQPTCTVGVWIDVGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VASEQSSQPTCTVGVWIDVGSR 22 0 P31930 P31930 UQCRC1 Cytochrome b-c1 complex subunit 1, mitochondrial 0 16424100.0 3964900.0 7879300.0 4579900.0 False True 6015043.173016939 6473177.353748115 3674680.757558522 1.0 1.0761647369026932 0.6109151093117471 22.520143661717032 -6.86490174123221 1.160818789761817 1.0419922053928714 0.5861931164983661 0.9593194214130571 0.04109623953846112 0.14183169530345302 0.36043492294004403 0.027553597005383998 0.06471193541612219 1.3648919073246335e-07 6.86490174123221 -0.45579908889450527 VASEQTEK(ub)LLNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VASEQTEKLLNK 12 1 Q8TD55-2;Q8TD55 Q8TD55-2 PLEKHO2 Pleckstrin homology domain-containing family O member 2 1 9424800.0 2461700.0 4113200.0 2849900.0 True False 3734578.874376608 3379167.323421715 2286616.015844457 1.0 0.9048322279672778 0.6122821589157489 21.83251413761249 -6.95090108953608 0.5488604768777642 1.0040734746314453 0.4993241354848826 0.999270121831112 0.00445715633223351 0.08312588884280125 0.03448021135583013 0.004844804922494935 0.024264338670950146 1.1196928642109808e-07 6.95090108953608 -0.5047493391465627 VASEQTEK(ub)LLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VASEQTEKLLNK 12 1 Q8TD55-2;Q8TD55 Q8TD55-2 PLEKHO2 Pleckstrin homology domain-containing family O member 2 1 3543060.0 1085800.0 1479100.0 978160.0 True False 1487249.602641693 1413748.4712703812 747138.7538375589 1.0 0.9505791554822021 0.5023627187463832 20.504215362157773 -6.927841188211774 0.7643163065965458 1.007390112090218 0.4152119819109895 0.9960963844758296 0.01398596497752573 0.09377484899458419 0.08328972506797024 0.012581827814804616 0.04104800132146999 1.1807523314612383e-07 6.927841188211774 -0.5921781301792285 VASEQTEK(ub)LLNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VASEQTEKLLNK 12 1 Q8TD55-2;Q8TD55 Q8TD55-2 PLEKHO2 Pleckstrin homology domain-containing family O member 2 1 3866520.0 1379000.0 1723800.0 763720.0 True False 1146699.6000582322 1714513.5472524911 923410.320957695 1.0 1.4951723600195064 0.8052765701765328 20.12905606855225 -6.714147203241511 1.7813038268280514 1.3031389990007656 0.8067534861606572 0.4843993940688116 0.20853363118308757 0.3667855751847191 2.271329072725354 0.09309202215186974 0.2352378425067858 1.9313135912052748e-07 6.714147203241511 -0.49638551284010834 VASEQTEK(ub)LLNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VASEQTEKLLNK 12 1 Q8TD55-2;Q8TD55 Q8TD55-2 PLEKHO2 Pleckstrin homology domain-containing family O member 2 1 8891200.0 2461700.0 3604800.0 2824700.0 True False 3186719.1773615386 3404189.71112613 2310633.583869549 1.0 1.0682427668272443 0.7250822727914954 21.603640459704938 -6.855014481429385 1.2105694538848815 1.0366404495648072 0.7099717124406434 0.9472975328151965 0.0340504121732955 0.1520279339381211 0.42620671184586684 0.0219774124652532 0.05105038773654208 1.3963218003154177e-07 6.855014481429385 -0.3266687371241638 VASGNDHLVMLTADGDLYTLGCGEQGQLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VASGNDHLVMLTADGDLYTLGCGEQGQLGR 30 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 53683600.0 7459600.0 34112000.0 12112000.0 False True 11316758.569809383 28024447.08172749 9718057.891121818 1.0 2.4763669657573626 0.8587315732834889 23.431957454102054 -6.666564730211889 1.9492664285096382 1.9451455894480632 0.865331787969269 0.26390130888516783 0.6276337061916376 0.46914378975841636 3.4331632978691693 0.25950398081170284 0.6965223541589126 2.1549404326081718e-07 6.666564730211889 -1.0798138014787941 VASLELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VASLELR 7 0 E7ENN3;A0A0C4DG40;Q8NF91-4;Q8NF91;Q8NF91-7 E7ENN3 SYNE1 Nesprin-1 0 93700000.0 26551000.0 26211000.0 40938000.0 False True 34808618.120249756 22300420.969677795 36702128.46502496 1.0 0.6406580374043813 1.0543977453581723 25.0529412053448 -6.6770750484783 1.9123928794214347 0.7720460514278906 1.0527855096566563 0.3107688477329775 0.15239589741161724 0.4450358608808764 3.1442499114399167 0.06400482124935755 0.16943660004682232 2.103414926675202e-07 6.6770750484783 0.28073945822876567 VASLELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VASLELR 7 0 E7ENN3;A0A0C4DG40;Q8NF91-4;Q8NF91;Q8NF91-7 E7ENN3 SYNE1 Nesprin-1 0 69118000.0 26093000.0 19003000.0 24022000.0 False True 25264691.99758609 26590996.999335885 17729917.555447362 1.0 1.0524963851479574 0.7017666218587333 24.590619256347743 -6.868800780609196 1.1404981316900105 1.0294820423247002 0.6816956835488767 0.9634675397453134 0.02952192842739491 0.1380058026650196 0.3362611309025064 0.02010406979781538 0.047497960486736296 1.352692927654751e-07 6.868800780609196 -0.34778635877582353 VASLELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VASLELR 7 0 E7ENN3;A0A0C4DG40;Q8NF91-4;Q8NF91;Q8NF91-7 E7ENN3 SYNE1 Nesprin-1 0 124426000.0 80384000.0 33139000.0 10903000.0 False True 121948404.85757366 27225086.53381119 8748017.27104533 1.0 0.22325086224463528 0.0717353972875852 26.86169564622751 -13.999999999979948 0.23101527173018355 5.930450576276512 2.8456907075398937e-11 0.9995063096762165 0.009034481776394848 13.368291246509898 0.15269419036157814 30.249707286180133 0.0778100374640094 1.0000000000461703e-14 13.999999999979948 -5.930450576248055 VASLELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VASLELR 7 0 E7ENN3;A0A0C4DG40;Q8NF91-4;Q8NF91;Q8NF91-7 E7ENN3 SYNE1 Nesprin-1 0 86604000.0 26551000.0 37735000.0 22318000.0 False True 36367622.213795915 36067742.927042 17046948.053638093 1.0 0.9917542234410872 0.4687396925051482 25.116151266867693 -6.910327370518643 0.8935035022196786 1.0160263839960704 0.40067364276904127 0.9910444970796779 0.023518109746614536 0.10420191271844925 0.13759633459494428 0.01928580983970831 0.05335901881166094 1.2293417455267532e-07 6.910327370518643 -0.6153527412270291 down VASLELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VASLELR 7 0 E7ENN3;A0A0C4DG40;Q8NF91-4;Q8NF91;Q8NF91-7 E7ENN3 SYNE1 Nesprin-1 0 70623000.0 26093000.0 29787000.0 14743000.0 False True 21697485.61589517 29626531.51874344 17825693.136069894 1.0 1.3654361635819958 0.821555707035986 24.37102453178202 -6.725655703658441 1.738777127684246 1.2209738441991957 0.8221110365143491 0.5391080014636531 0.15368064262844727 0.3444615948512783 2.038100258135629 0.0700957793180261 0.17481941063240994 1.880807276566515e-07 6.725655703658441 -0.3988628076848466 VASLELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VASLELR 7 0 E7ENN3;A0A0C4DG40;Q8NF91-4;Q8NF91;Q8NF91-7 E7ENN3 SYNE1 Nesprin-1 0 102168900.0 80384000.0 14915000.0 6869900.0 False True 104058672.60552861 14084967.138661303 5619648.691126643 1.0 0.13535601392932792 0.05400461634207001 26.63282196831996 -13.900919511257987 0.33513869106988964 9.999999999999986 0.040357860210533114 0.9997220726885176 0.00713628621611406 18.00311215708032 0.1851261335534224 114.16795938633645 0.025594016884934335 1.256262768035469e-14 13.900919511257987 -9.959642139789453 VASLLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VASLLVK 7 0 P00492;Q9NRG1-2;Q9NRG1 P00492 HPRT1;PRTFDC1 Hypoxanthine-guanine phosphoribosyltransferase;Phosphoribosyltransferase domain-containing protein 1 0 8164500.0 2186800.0 3299900.0 2677800.0 False True 2866915.9770013215 2807567.782909452 2400726.94327138 1.0 0.9792989419404103 0.8373900604448281 21.45106819230518 -6.933088710259915 0.7210204040792729 1.0019303698725095 0.8058280993791987 0.997110678868607 0.0038847680695785944 0.09106608564612353 0.07006217465400999 0.0036065749222128616 0.012629386372185438 1.1665713054590172e-07 6.933088710259915 -0.19610227049331075 VASLLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VASLLVK 7 0 P00492;Q9NRG1-2;Q9NRG1 P00492 HPRT1;PRTFDC1 Hypoxanthine-guanine phosphoribosyltransferase;Phosphoribosyltransferase domain-containing protein 1 0 5667980.0 2492400.0 820680.0 2354900.0 False True 2413280.1262707836 1148381.8037896636 1738081.044514317 1.0 0.4758593050547538 0.7202152065123726 21.202563958282433 -10.39081803484344 5.994059495970747 1.0000896835641688 0.5980372557835647 0.7829853861052914 0.0997578790348298 0.00011958568280299793 1.215365373481431e-05 0.09661155246986391 0.032196717012905704 4.06613660641254e-11 10.39081803484344 -0.4020524277806041 VASLLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VASLLVK 7 0 P00492;Q9NRG1-2;Q9NRG1 P00492 HPRT1;PRTFDC1 Hypoxanthine-guanine phosphoribosyltransferase;Phosphoribosyltransferase domain-containing protein 1 0 10799100.0 2186800.0 3876000.0 4736300.0 False True 2995319.0560479383 3704745.5037820297 3617683.487160408 1.0 1.23684503535664 1.2077790110058009 21.51427825382807 -10.174290218947146 4.968194934309177 0.9999824338976955 1.2223120231816336 0.9873417337906043 0.01186615475324209 2.308988112180785e-06 3.837398966794865e-07 0.011490262261466504 0.003829784978364345 6.694371060059705e-11 10.174290218947146 0.2223295892839381 VASPK(ub)LVMEEAPESYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VASPKLVMEEAPESYK 16 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 20373500.0 9994200.0 5808700.0 4570600.0 True False 9676939.591548504 8128144.201970326 3373422.744939127 1.0 0.8399498751722247 0.34860429922341923 23.20611942527455 -6.950931688544874 0.5485238604699534 1.0068553812870924 0.1586746269038496 0.9992723584384293 0.007476309152072458 0.08311384869629823 0.03443121074777718 0.008130084855595326 0.040750016110989946 1.119613976989805e-07 6.950931688544874 -0.8481807543832428 down VASPK(ub)LVMEEAPESYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VASPKLVMEEAPESYK 16 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 21881900.0 9994200.0 9321400.0 2566300.0 True False 8310620.118130523 9271183.768046962 3102901.464769456 1.0 1.115582668472701 0.3733658163486668 22.986524700708827 -6.867123074143103 1.149283095013131 1.064352872723331 0.3322239629392046 0.9617224233565861 0.06379516724494158 0.13963901338881105 0.34653619139126923 0.04315201609898428 0.10167854082914306 1.3579285704600097e-07 6.867123074143103 -0.7321289097841264 down VASPK(ub)LVMEEAPESYK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VASPKLVMEEAPESYK 16 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 63612900.0 24737700.0 10040200.0 28835000.0 True False 32023440.302968055 9481454.043954886 23587325.872084998 1.0 0.2960785585262714 0.7365643931110935 24.932624970236088 -10.26878015350108 7.3067848113090115 1.0000021962953252 0.5163214758197943 0.616511290465174 0.17982758894280154 6.434145024850541e-06 6.437800382591423e-07 0.1741181053907487 0.0580391047636753 5.385423318787068e-11 10.26878015350108 -0.4836807204755309 VASVAENK(ub)GLFEEAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VASVAENKGLFEEAAK 16 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BVE2 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 6677300.0 2222100.0 2463400.0 1991800.0 True False 2913194.6188470116 2095870.322257994 1785707.6426947261 1.0 0.7194405443078501 0.6129723126433194 21.474170654690692 -13.999999999999998 0.1343429335621659 2.3350377650014313 0.4717797176275097 0.9996264173623646 0.0031552351882839437 11.932475887980122 0.1143891778756191 4.191506443574627 0.12580613265923402 1.0000000000000041e-14 13.999999999999998 -1.8632580473739218 VASVAENK(ub)GLFEEAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VASVAENKGLFEEAAK 16 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BVE2 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 4351000.0 1771300.0 2579700.0 0.0 True False 1715071.051060601 3609787.6629577787 0.0 1.0 2.1047452586442317 0.0 20.709836914170943 -6.768715200051549 1.6097001252331549 1.6382204596967775 2.3181678974590056e-11 0.7072090808069362 0.4651380953808404 0.2727344384148888 1.3994246149936158 0.22894608013056067 0.539026930971129 1.7032751093701525e-07 6.768715200051549 -1.6382204596735959 VASVAENK(ub)GLFEEAAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VASVAENKGLFEEAAK 16 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BVE2 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 8798900.0 1771300.0 3820700.0 3206900.0 True False 1472914.4318949578 3800117.1307504303 3877447.962969713 1.0 2.5799985718528413 2.6325004895099275 20.49024218960522 -10.665359394240516 0.6300941259868923 1.988849323336021e-12 2.625291955572465 0.9998972855801481 0.007677083591669235 2.1880023083671984 0.3118443766061754 3.419146176716768 0.008791116727878868 2.1609295370058912e-11 10.665359394240516 2.6252919555704763 VASVAENK(ub)GLFEEAAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VASVAENKGLFEEAAK 16 1 Q8N1F7;H3BVG0;Q8N1F7-2;H3BVE2 Q8N1F7 NUP93 Nuclear pore complex protein Nup93 1 49353300.0 9429000.0 3777300.0 36147000.0 True False 12206026.373376904 3567089.9344864395 29568616.89954073 1.0 0.29224006448706147 2.4224605121314604 23.54109027694824 -6.817148167132909 1.384156998431543 0.6173789160504343 2.466182439492528 0.8776894069720822 0.3097986144717168 0.19722169741397216 0.7432202654042865 0.17591393447900555 0.4057960661206737 1.5235328853199352e-07 6.817148167132909 1.8488035234420939 VASVEMVK(ub)YHHCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VASVEMVKYHHCR 13 1 P08243-2;P08243;P08243-3;F8WEJ5;C9J057 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 8306400.0 2562800.0 3080700.0 2662900.0 True False 2481445.316805797 4310839.575638264 1965406.6047123768 1.0 1.737229326168399 0.7920410703397311 21.24274923188089 -6.69857897753609 1.8356091720618788 1.45843754403936 0.7949038656571048 0.4108327319791699 0.31127818868617013 0.39856881546576733 2.6098322094399133 0.13532570802747437 0.34867619998005195 2.0018015558749156e-07 6.69857897753609 -0.6635336783822552 VASVEMVK(ub)YHHCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VASVEMVKYHHCR 13 1 P08243-2;P08243;P08243-3;F8WEJ5;C9J057 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 67172000.0 12633000.0 15312000.0 39227000.0 True False 19165184.596010778 12579453.966797948 31473766.25619514 1.0 0.6563700914947803 1.642236530440014 24.191984558226135 -6.812557109216278 1.403835642008921 0.8132855175606699 1.660498588981063 0.866384137493798 0.14935246012559394 0.20333223559967614 0.7892931917762367 0.0836441794052021 0.19326467598867422 1.5397240408364922e-07 6.812557109216278 0.8472130714203931 VASVEMVK(ub)YHHCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VASVEMVKYHHCR 13 1 P08243-2;P08243;P08243-3;F8WEJ5;C9J057 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 9738700.0 2562800.0 2430900.0 4745000.0 True False 2131081.751290238 2417804.259204129 5737157.561598824 1.0 1.134543176365852 2.6921339634790318 21.023154507315166 -6.923917985032039 0.7951264100268696 0.9702394372465012 2.967433344108207 0.9952019365140428 0.053193317631284744 0.09592084409170908 0.0940671500001429 0.04680971680258684 0.14593041439128526 1.191466991085857e-07 6.923917985032039 1.997193906861706 up VASVEMVK(ub)YHHCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VASVEMVKYHHCR 13 1 P08243-2;P08243;P08243-3;F8WEJ5;C9J057 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 58984000.0 12633000.0 14255000.0 32096000.0 True False 16353667.533658998 13461696.7188479 26254857.332770564 1.0 0.82316071860585 1.6054415487371876 23.963110880318585 -6.847314330797581 1.2480112624304298 0.9058077928181006 1.6351257734070472 0.9363018989883375 0.08453928548033388 0.16043564572890107 0.4822197429742613 0.05304120768693384 0.12254618518919368 1.421299715820304e-07 6.847314330797581 0.7293179805889466 VASVSQNAIVSAAGNIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VASVSQNAIVSAAGNIAR 18 0 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 0 2967400.0 0.0 1436000.0 1531400.0 False True 0.0 1221754.3974841603 1372945.418226078 0.0 VASVSQNAIVSAAGNIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VASVSQNAIVSAAGNIAR 18 0 O75694;O75694-2;E9PF10 O75694 NUP155 Nuclear pore complex protein Nup155 0 2824000.0 0.0 1373200.0 1450800.0 False True 0.0 1312527.4834348515 1108150.9201639083 0.0 VATWFNQPAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VATWFNQPAR 10 0 P26373;J3QSB4;P26373-2;H3BTH3 P26373 RPL13 60S ribosomal protein L13 0 10024000.0 3970800.0 1774300.0 4278900.0 False True 3844749.127506025 2482787.2428522687 3158127.7257515476 1.0 0.6457605322256174 0.821413210853664 21.874458033750322 -10.101518831745258 5.108117000057903 1.000006855019108 0.7335868715390651 0.7541298924653541 0.07170990576730142 5.598328839050424e-06 9.848302032945994e-07 0.06943460303945409 0.02314427256595094 7.915551307072243e-11 10.101518831745258 -0.2664199834800428 VATWFNQPAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VATWFNQPAR 10 0 P26373;J3QSB4;P26373-2;H3BTH3 P26373 RPL13 60S ribosomal protein L13 0 7742790.0 3970800.0 2778300.0 993690.0 False True 3301896.1362662953 2763332.7464506263 1201465.9846965524 1.0 0.836892692080659 0.3638715256668071 21.6548633091846 -6.952210094978312 0.5340331877602731 1.0072507988028454 0.17189151822687337 0.9993634836817985 0.006806253787277416 0.08261030240150569 0.032382556690676786 0.007549009076769571 0.03913766820193774 1.1163230829337587e-07 6.952210094978312 -0.835359280575972 down VAVEAK(ub)NPADLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAVEAKNPADLPK 13 1 P13639 P13639 EEF2 Elongation factor 2 1 25139700.0 7997300.0 8779000.0 8363400.0 True False 10484537.745963357 7469207.420273971 7498035.595397678 1.0 0.7124021679591629 0.7151517574806281 23.321759919894262 -10.222159470823176 5.3616145282461485 1.0000193295866266 0.713776963597616 0.9999307899361561 0.001122515221758068 2.593829497284505e-07 3.763046939441981e-08 0.0010869440291044485 0.00036229022995731364 5.995708763178138e-11 10.222159470823176 -0.28624236598901065 VAVEAK(ub)NPADLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAVEAKNPADLPK 13 1 P13639 P13639 EEF2 Elongation factor 2 1 35280500.0 9157900.0 7098600.0 19024000.0 True False 8867187.477281023 9933107.998709956 14041043.692233387 1.0 1.1202095392885254 1.5834833455600785 23.080045147806064 -6.9457309771675195 0.6039053550615466 0.9948234604732031 1.7327437926742122 0.9988221706852847 0.008633293724185866 0.08524679391955166 0.043417020033912374 0.00882694492361491 0.03898259368954376 1.1331020436395185e-07 6.9457309771675195 0.737920332201009 VAVEAK(ub)NPADLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAVEAKNPADLPK 13 1 P13639 P13639 EEF2 Elongation factor 2 1 104436000.0 16971000.0 25519000.0 61946000.0 True False 25746247.746291324 20964935.069142964 49702345.948103674 1.0 0.8142908930161641 1.9304694974537857 24.617858853700813 -6.8641548788889155 1.1646536661742075 0.8979086772212252 1.988947069199467 0.95848850443674 0.09949231460117113 0.14257772654888215 0.3651712307881476 0.06651012787573603 0.15604524635958553 1.367241150614593e-07 6.8641548788889155 1.0910383919782418 VAVEAK(ub)NPADLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAVEAKNPADLPK 13 1 P13639 P13639 EEF2 Elongation factor 2 1 23539100.0 7997300.0 7114300.0 8427500.0 True False 10954117.928906247 6799966.702155966 6437098.069810683 1.0 0.6207680751922426 0.587641844974497 23.384969981417154 -13.999999999999991 0.34516197031571316 5.526940399570999 0.582767737249822 0.9997453834290126 0.002985000781890503 20.187670899549875 0.1887911743322489 66.84994555990693 0.01005007065022313 1.0000000000000205e-14 13.999999999999991 -4.9441726623211775 VAVEAK(ub)NPADLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAVEAKNPADLPK 13 1 P13639 P13639 EEF2 Elongation factor 2 1 33284600.0 9157900.0 16145000.0 7981700.0 True False 7615199.613758726 16058023.680468397 9650636.566788921 1.0 2.108680598661608 1.2672860931120806 22.86045042324034 -10.14108501106242 4.501139898058207 0.9999263045004171 1.687983345724362 0.47130408112242206 0.34349786875406674 240076835.23203284 43.150910839912605 233000.7781055287 0.11758845694173375 7.226283387247336e-11 10.14108501106242 0.688057041223945 VAVEAK(ub)NPADLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAVEAKNPADLPK 13 1 P13639 P13639 EEF2 Elongation factor 2 1 82272000.0 16971000.0 24648000.0 40653000.0 True False 21969294.048422888 23276317.132666662 33254571.135005046 1.0 1.0594931763106699 1.513684102079388 24.388985175793263 -6.930976623856342 0.7387255192182355 0.9933376736775621 1.609291337017974 0.9967268907684301 0.013125345167028695 0.09213352765101097 0.07521719200914549 0.012028126931848536 0.040877836155842055 1.1722584613180826e-07 6.930976623856342 0.6159536633404119 VAVEEVDEEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAVEEVDEEGK 11 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 9109400.0 1033200.0 4709800.0 3366400.0 False True 1354535.205523031 4007116.1986566074 3018077.220788996 1.0 2.958296087335232 2.2281275587987515 20.369366460223596 -10.321239816672337 5.666273520501667 0.9997728918775256 2.593211823067005 0.8639092610027512 0.2980900535255783 0.0008553366406793377 0.00010246090431324877 0.2886630261491926 0.09620815108121354 4.77265655598492e-11 10.321239816672337 1.5934389311894792 VAVEEVDEEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAVEEVDEEGK 11 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 10750860.0 3314700.0 961960.0 6474200.0 False True 3209476.6628750484 1346075.6445551286 4778412.798163228 1.0 0.41940658429630534 1.4888448492043955 21.61390664005868 -6.759266734782609 1.6151873451227714 0.6624524033680811 1.492616769883474 0.6879848399999111 0.24417434726467152 0.2841506714944372 1.4608591843429801 0.1192859751780456 0.2868758415057144 1.7407374197093154e-07 6.759266734782609 0.8301643665153929 VAVEEVDEEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAVEEVDEEGK 11 0 P02545;P02545-3;P02545-6;P02545-5;P02545-4;A0A0C4DGC5;P02545-2;Q5TCI8 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 0 8908900.0 1033200.0 4079500.0 3796200.0 False True 1415201.9611801396 3899254.2008975246 2899615.7451931555 1.0 2.7552634237772886 2.048905968710756 20.432576521746487 -10.449804947309506 5.8158033827275375 0.9991149903622636 2.402084696244023 0.8400862807055652 0.28836922348732014 0.0033107084195448506 0.0003132044020446018 0.27934895945904914 0.09307076667709581 3.549727807358508e-11 10.449804947309506 1.4029697058817596 VAVEYLDPSPEVQKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAVEYLDPSPEVQKK 15 1 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 104285200.0 47818000.0 48316000.0 8151200.0 True False 39762785.69658053 48055712.118024915 9855578.233109469 1.0 1.2085599958897637 0.24785935040655405 25.244915496812457 -6.84985135957586 1.2357290919435584 1.1112866701696273 0.2095483340031338 0.9400961940124479 0.10098521826473197 0.1576238588246634 0.4632423866741535 0.06394724771815903 0.14797082741824694 1.41302107854453e-07 6.84985135957586 -0.9017383361664936 down VAVEYLDPSPEVQKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAVEYLDPSPEVQKK 15 1 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 164708000.0 94670000.0 34636000.0 35402000.0 True False 122552181.22468893 32708476.15250904 28959199.25519514 1.0 0.2668942798540717 0.23630096964248173 26.868820921100774 -13.329029761173528 0.46006219786210834 9.998885020157068 0.2366758884857774 0.999898979879752 0.003548168526515954 19.805239848629693 0.23201107856754893 177.70959469145183 0.006756090921944137 4.687812565739148e-14 13.329029761173528 -9.762209131671291 VAVFFGGLSIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAVFFGGLSIK 11 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;A0A140T996;A0A140T9X9;F6UJC5;A0A140TA18;F6R6M7;A0A140T9K1;A0A140T973;A0A140T9L4;A0A140T9N3;A0A140T9K2;F6QYI9;A0A0G2JJL7 Q13838-2;F6QYI9 DDX39B Spliceosome RNA helicase DDX39B 0 59989000.0 18904000.0 24287000.0 16798000.0 False True 24783327.066596393 20663474.269984517 15059904.09779397 1.0 0.833765144383511 0.6076627265308578 24.562866540966805 -6.966832711557156 0.32506548597968854 1.029180524192937 0.40489975013027046 0.9999460905001576 0.001180566003740279 0.07734443177480205 0.012695830877813672 0.0033597275304896785 0.019801599293423774 1.0793624081113799e-07 6.966832711557156 -0.6242807740626666 VAVFFGGLSIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAVFFGGLSIK 11 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;A0A140T996;A0A140T9X9;F6UJC5;A0A140TA18;F6R6M7;A0A140T9K1;A0A140T973;A0A140T9L4;A0A140T9N3;A0A140T9K2;F6QYI9;A0A0G2JJL7 Q13838-2;F6QYI9 DDX39B Spliceosome RNA helicase DDX39B 0 90316000.0 36260000.0 26812000.0 27244000.0 False True 35108946.147720516 37518171.42273285 20107979.09751923 1.0 1.0686214067740896 0.5727309219967789 25.06533535623551 -6.871916299417161 1.123973669584141 1.0392939835056898 0.5426198100282673 0.9665553596066468 0.04012118634018481 0.1350274169634771 0.3176590327834054 0.027670406929235183 0.06573452873514828 1.3430237740991071e-07 6.871916299417161 -0.4966741734774225 VAVFFGGLSIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAVFFGGLSIK 11 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;A0A140T996;A0A140T9X9;F6UJC5;A0A140TA18;F6R6M7;A0A140T9K1;A0A140T973;A0A140T9L4;A0A140T9N3;A0A140T9K2;F6QYI9;A0A0G2JJL7 Q13838-2;F6QYI9 DDX39B Spliceosome RNA helicase DDX39B 0 375230000.0 104900000.0 118810000.0 151520000.0 False True 159140969.21725067 97607427.23323296 121572005.58642472 1.0 0.6133394041353648 0.763926512351833 27.245730049687875 -10.082606569473493 4.981682509400252 1.0000083774113668 0.6886329597508032 0.8507560837854906 0.06147692950063182 5.720211612507326e-06 1.0534002259434592e-06 0.05952638239541161 0.019841593676892835 8.267866024110716e-11 10.082606569473493 -0.31137541766056365 VAVFFGGLSIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAVFFGGLSIK 11 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;A0A140T996;A0A140T9X9;F6UJC5;A0A140TA18;F6R6M7;A0A140T9K1;A0A140T973;A0A140T9L4;A0A140T9N3;A0A140T9K2;F6QYI9;A0A0G2JJL7 Q13838-2;F6QYI9 DDX39B Spliceosome RNA helicase DDX39B 0 96903000.0 18904000.0 30664000.0 47335000.0 False True 25893319.661391184 29309163.087712124 36155447.89492598 1.0 1.1319198724223147 1.3963233902695131 24.626076602489697 -6.960003156539836 0.43539075727119975 0.9900786481156781 1.548394807755003 0.9997703115609868 0.0024973752680954044 0.07970001175325697 0.02112727915517119 0.0034671006896946775 0.021927593808947692 1.0964702267475987e-07 6.960003156539836 0.5583161596393248 VAVFFGGLSIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAVFFGGLSIK 11 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;A0A140T996;A0A140T9X9;F6UJC5;A0A140TA18;F6R6M7;A0A140T9K1;A0A140T973;A0A140T9L4;A0A140T9N3;A0A140T9K2;F6QYI9;A0A0G2JJL7 Q13838-2;F6QYI9 DDX39B Spliceosome RNA helicase DDX39B 0 85432000.0 36260000.0 23052000.0 26120000.0 False True 30151796.59036365 22927814.30053625 31581571.234765325 1.0 0.7604128739666496 1.0474192189548872 24.845740631669788 -6.685272530795815 1.8840567348584942 0.8491266726774843 1.0463523503622647 0.3480637319829851 0.10142872970334373 0.4268836129074439 2.9342569625030466 0.04313645361436538 0.11296932045693255 2.0640844839858384e-07 6.685272530795815 0.1972256776847804 VAVFFGGLSIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAVFFGGLSIK 11 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;F6WLT2;F6TRA5;A0A0A0MT12;F6S4E6;A0A140T996;A0A140T9X9;F6UJC5;A0A140TA18;F6R6M7;A0A140T9K1;A0A140T973;A0A140T9L4;A0A140T9N3;A0A140T9K2;F6QYI9;A0A0G2JJL7 Q13838-2;F6QYI9 DDX39B Spliceosome RNA helicase DDX39B 0 336931000.0 104900000.0 138340000.0 93691000.0 False True 135795117.88813633 130641257.38936664 76640199.35084152 1.0 0.9620467909382775 0.5643811098862572 27.016856371780325 -6.925446228108609 0.7832739497492823 1.007175540318266 0.491468021395574 0.9955648962028812 0.013120674413428 0.09507243867070087 0.08977772393006993 0.011644204013343729 0.03692377266913405 1.1872816944613055e-07 6.925446228108609 -0.5157075189226921 VAVGELTDEDVK(ub)MITSLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAVGELTDEDVKMITSLSK 19 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 7394000.0 5149900.0 0.0 2244100.0 True False 4282370.029253002 0.0 2713330.9344539405 1.0 0.0 0.6336049701261435 22.029978030228293 -10.229818753302958 7.214002930337993 1.0000018987006862 0.31680248506307185 0.6078774099503028 0.2586681458834051 7.899165069823025e-06 8.432617460987993e-07 0.2504550492122341 0.0834847851000649 5.890894522640122e-11 10.229818753302958 -0.6831994136376144 VAVGELTDEDVK(ub)MITSLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAVGELTDEDVKMITSLSK 19 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 29003100.0 5833500.0 6522600.0 16647000.0 True False 7551580.745476116 6159611.576173786 13617416.812644307 1.0 0.8156718154492079 1.8032538181892601 22.8483472395837 -6.8584699070982 1.1934823056983526 0.9003723433741098 1.8496891256522139 0.9517487144824683 0.09418204617690842 0.14838682107290777 0.4025080004687325 0.061586806388470666 0.14351970693349783 1.3852561690312666e-07 6.8584699070982 0.9493167822781041 VAVLDGK(ub)HTGPITCLQFNPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAVLDGKHTGPITCLQFNPK 20 1 Q6UXN9 Q6UXN9 WDR82 WD repeat-containing protein 82 1 40064500.0 14794000.0 21913000.0 3357500.0 True False 19395077.265299797 18643665.816205 3010098.1074141674 1.0 0.9612576202292751 0.15519907790208223 24.209187187440634 -6.916915845742515 0.8472978482950478 1.0198387548201167 0.03401383623702146 0.9932799971911374 0.03192398185456993 0.10002109520509785 0.11527343212581091 0.027065477368764735 0.0788290445777381 1.2108327367112322e-07 6.916915845742515 -0.9858249185830952 down VAVLDGK(ub)HTGPITCLQFNPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAVLDGKHTGPITCLQFNPK 20 1 Q6UXN9 Q6UXN9 WDR82 WD repeat-containing protein 82 1 40564600.0 24607000.0 10561000.0 5396600.0 True False 20461810.77493322 10504105.796805639 6525004.108940828 1.0 0.5133517220124875 0.3188869343339983 24.286430486734684 -13.999999999997128 0.1265159521894359 3.312759333467966 0.03410683573467061 0.9996616623593121 0.005269215712110949 11.943493742098095 0.11025198574668206 6.892060820486206 0.2529823888887028 1.0000000000066138e-14 13.999999999997128 -3.278652497733295 VAVLGASGGIGQPLSLLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAVLGASGGIGQPLSLLLK 19 0 P40926;P40926-2 P40926 MDH2 Malate dehydrogenase, mitochondrial 0 954830000.0 498520000.0 235350000.0 220960000.0 False True 482694755.4760521 329326482.33403623 163083947.34208813 1.0 0.6822665433960263 0.33786144450906347 28.846535910949168 -7.180629507763018 0.2847339688490456 1.08148169471377 1.0104387107489305e-16 0.9999447142522684 0.0020104601460216877 0.08701659006621641 0.014256523509728771 0.00958450765083764 0.03806159837867796 6.597364697671838e-08 7.180629507763018 -1.08148169471377 down VAVLGASGGIGQPLSLLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAVLGASGGIGQPLSLLLK 19 0 P40926;P40926-2 P40926 MDH2 Malate dehydrogenase, mitochondrial 0 1155880000.0 231200000.0 488260000.0 436420000.0 False True 350747302.9840646 401126188.20720834 350161395.7103188 1.0 1.1436329938805905 0.9983295458902719 28.385856769611287 -6.648831236488228 2.0128474423954246 1.0932896498393276 0.9989413989614147 0.18931164183870897 0.06132178789252185 0.5113692958021194 3.969957548901623 0.02471980974867394 0.06791237420237785 2.2447540485642153e-07 6.648831236488228 -0.09434825087791299 VAVLGASGGIGQPLSLLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAVLGASGGIGQPLSLLLK 19 0 P40926;P40926-2 P40926 MDH2 Malate dehydrogenase, mitochondrial 0 285976000.0 112800000.0 33746000.0 139430000.0 False True 154505208.30538136 32254990.136901043 106499505.65098836 1.0 0.20876312514429077 0.6892939520879505 27.20308023068937 -10.41710333477189 5.513718342968315 1.0003366674032121 0.44902853863472264 0.6367452636012938 0.19617588861494611 0.0008123634750526776 8.588067202111432e-05 0.19005904811406257 0.06331549579442576 3.8273366594131844e-11 10.41710333477189 -0.5513081287684896 VAVLGASGGIGQPLSLLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAVLGASGGIGQPLSLLLK 19 0 P40926;P40926-2 P40926 MDH2 Malate dehydrogenase, mitochondrial 0 784340000.0 498520000.0 120110000.0 165710000.0 False True 414541468.18058753 119462943.59003174 200359194.84352824 1.0 0.28818092461135847 0.4833272669267562 28.626941186383444 -10.400552587951587 5.221845979507129 1.0004551140162101 0.3857540957690364 0.9296269666055125 0.0796681606406101 0.0004224150054295714 4.849165502689226e-05 0.07719317902262003 0.025712788281994487 3.9760094876308145e-11 10.400552587951587 -0.6147010182471737 VAVLGASGGIGQPLSLLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAVLGASGGIGQPLSLLLK 19 0 P40926;P40926-2 P40926 MDH2 Malate dehydrogenase, mitochondrial 0 637830000.0 231200000.0 208200000.0 198430000.0 False True 299292957.6333378 196613486.9774911 162317776.06373578 1.0 0.6569265395758535 0.5423374386997453 28.156983091703736 -13.999999999999998 0.15320049600381364 2.6676129875081935 0.42079047763871974 0.9995559101956631 0.004097652923155158 11.971175065268483 0.12342503969358583 5.937931458952874 0.10991081784981822 1.0000000000000041e-14 13.999999999999998 -2.2468225098694736 VAVLISGTGSNLQALIDSTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAVLISGTGSNLQALIDSTR 20 0 P22102;A0A140TA71 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 185967000.0 56171000.0 75064000.0 54732000.0 False True 85215513.65016387 61668242.72229117 43914196.21011223 1.0 0.7236738955239822 0.5153310040516054 26.344612764014048 -7.319735018667932 0.13991252328147755 1.3054805457147103 3.130265798199523e-14 0.999995022657043 0.00044284419863569564 0.11122223178175074 0.008541101885439821 0.026596697424258908 0.04917984596812023 4.7892221378434075e-08 7.319735018667932 -1.305480545714679 VAVLISGTGSNLQALIDSTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAVLISGTGSNLQALIDSTR 20 0 P22102;A0A140TA71 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 119947000.0 56171000.0 27414000.0 36362000.0 False True 72714466.79594384 25888386.801157285 29744489.105627015 1.0 0.3560280084815446 0.409058752903985 26.115739086106498 -10.414384008545747 9.24626361042899 1.0000023760008898 0.3825433828987241 0.994498161669605 0.021649710752487422 1.0603913046772264e-06 6.716009410312033e-08 0.020962322834260257 0.00698741409954932 3.8513766358525624e-11 10.414384008545747 -0.6174589931021657 VAVLLLAGGQGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAVLLLAGGQGTR 13 0 Q16222;Q16222-3;Q16222-2;Q3KQV9 Q16222 UAP1;UAP1L1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase;UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 0 32322000.0 10662000.0 10182000.0 11478000.0 False True 13977985.250954889 8662885.289125139 10290366.664750522 1.0 0.6197520696720827 0.7361838262096856 23.736653093742795 -10.606955753382142 9.560578368396833 1.0000562559907207 0.6779679479408847 0.9107131358129086 0.04753306556218107 5.700671954961679e-05 2.3436062458046804e-06 0.04603166216481701 0.015341230943042728 2.471975981061959e-11 10.606955753382142 -0.322088308049836 VAVLLLAGGQGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAVLLLAGGQGTR 13 0 Q16222;Q16222-3;Q16222-2;Q3KQV9 Q16222 UAP1;UAP1L1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase;UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 0 34015800.0 12645000.0 7240800.0 14130000.0 False True 12243591.396523051 10132089.200273165 10428929.109086283 1.0 0.8275422522798733 0.8517867651192527 23.54552346815459 -10.017171425750591 6.911778877486143 1.0000000258188042 0.8396645087281477 0.983140503904701 0.00989778091980652 3.934664392340598e-09 5.578502672158131e-10 0.009583486594753828 0.00319449505556824 9.612327834010629e-11 10.017171425750591 -0.16033551709065652 VAVLLLAGGQGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAVLLLAGGQGTR 13 0 Q16222;Q16222-3;Q16222-2;Q3KQV9 Q16222 UAP1;UAP1L1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase;UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 0 70191000.0 17582000.0 26689000.0 25920000.0 False True 26673179.41637467 21926139.427891243 20796900.63886043 1.0 0.822029465839786 0.7796933509206334 24.668886467159886 -13.999999999999998 0.20171825435667512 1.9958452830958469 0.7526591897165695 0.9994870808073855 0.002161777147632209 12.565415692568445 0.14240470705202124 4.940647040842452 0.026616146073472974 1.0000000000000041e-14 13.999999999999998 -1.2431860933792773 VAVLLLAGGQGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAVLLLAGGQGTR 13 0 Q16222;Q16222-3;Q16222-2;Q3KQV9 Q16222 UAP1;UAP1L1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase;UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 0 48666000.0 10662000.0 11423000.0 26581000.0 False True 14604029.529716108 10918294.089190427 20303115.252879016 1.0 0.7476220221942177 1.3902406326669277 23.799863155265687 -6.800155767771621 1.4551477054935456 0.8607814945417785 1.3991602796486673 0.8326696115042977 0.10813620728567194 0.22052450941917184 0.9218400237899562 0.05845989605910514 0.1359511163726254 1.5843248430502298e-07 6.800155767771621 0.5383787851068887 VAVLLLAGGQGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAVLLLAGGQGTR 13 0 Q16222;Q16222-3;Q16222-2;Q3KQV9 Q16222 UAP1;UAP1L1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase;UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 0 24923700.0 12645000.0 4980300.0 7298400.0 False True 10514877.768481752 4953470.135387845 8824461.696011154 1.0 0.47109155659762647 0.8392357847908033 23.325928743588868 -10.092848237514461 6.025948653632872 1.0000011780482314 0.6551636706942108 0.5391378443978982 0.15029425180403716 2.378615232295654e-06 3.580541734547408e-07 0.1455222801019376 0.04850726118897332 8.075171646234852e-11 10.092848237514461 -0.34483750735402063 VAVLLLAGGQGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAVLLLAGGQGTR 13 0 Q16222;Q16222-3;Q16222-2;Q3KQV9 Q16222 UAP1;UAP1L1 UDP-N-acetylhexosamine pyrophosphorylase;UDP-N-acetylgalactosamine pyrophosphorylase;UDP-N-acetylglucosamine pyrophosphorylase;UDP-N-acetylhexosamine pyrophosphorylase-like protein 1 0 61898000.0 17582000.0 27030000.0 17286000.0 False True 22760245.5930335 25525756.73872039 14140125.369337987 1.0 1.1215062084625909 0.6212641823894037 24.440012789252336 -6.842522135860199 1.2706371730163988 1.0646318168632916 0.6039726317153579 0.9287043685333911 0.05688239570696145 0.16587243235015933 0.5191193597356616 0.03508769055507802 0.08089794739646343 1.4370698044703912e-07 6.842522135860199 -0.4606591851479337 VAVPLLSSGGQVAVLELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAVPLLSSGGQVAVLELR 18 0 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 0 9953800.0 3273400.0 4327100.0 2353300.0 False True 4291459.09965069 3681513.546903692 2109803.090447584 1.0 0.8578698902672414 0.49162838126997754 22.033036817965705 -6.954809871556913 0.5032775494157001 1.0071308627634845 0.32648276565552586 0.9995266823243093 0.004659204115216965 0.08160990889195643 0.028399661826030778 0.005430945767264452 0.030215492131762025 1.1096605037934782e-07 6.954809871556913 -0.6806480971079587 down VAVPLLSSGGQVAVLELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAVPLLSSGGQVAVLELR 18 0 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 0 31101300.0 16710000.0 8874200.0 5517100.0 False True 16179550.196591567 12417714.338341637 4072006.0005477658 1.0 0.7674944103796897 0.25167609427149507 23.947668164552542 -6.988317040388548 0.4721475045019666 1.0133626732483676 1.7505073941924695e-11 0.9996858627243451 0.005542532103158215 0.07632117209697581 0.024131758051097747 0.007019922819932391 0.04027342017269185 1.0272661072645179e-07 6.988317040388548 -1.0133626732308625 down VAVPLLSSGGQVAVLELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAVPLLSSGGQVAVLELR 18 0 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 0 68705000.0 12329000.0 38203000.0 18173000.0 False True 18703994.3706338 31385376.16859866 14581098.584491147 1.0 1.6780039357729524 0.7795713736625262 24.156843064983953 -6.704813783231733 1.8134780641000312 1.4190019468903243 0.7819669289203874 0.4405757382090102 0.2859486712472751 0.38557923902971275 2.468418400743836 0.12563193910532616 0.3212131001415134 1.9732686527893437e-07 6.704813783231733 -0.6370350179699369 VAVPLLSSGGQVAVLELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAVPLLSSGGQVAVLELR 18 0 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 0 25640300.0 3273400.0 4869900.0 17497000.0 False True 4483664.4403088195 4654731.715394247 13364568.962026423 1.0 1.0381534517943642 2.980724614865674 22.096246879488596 -6.911149942727215 0.8878699876052456 0.9420196170451818 3.2380414163792244 0.9913482810436207 0.08602557791493297 0.10366241763643143 0.13467979238742459 0.07083321516716487 0.19712455810081436 1.2270155236840464e-07 6.911149942727215 2.2960217993340426 up VAVPLLSSGGQVAVLELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAVPLLSSGGQVAVLELR 18 0 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 0 26017900.0 16710000.0 3503000.0 5804900.0 False True 13895105.378515637 3484128.64370894 7018677.751174935 1.0 0.2507450320669059 0.505118713387168 23.72807343998682 -10.27148255014936 5.573691509144008 1.0000541135998113 0.3779318727290911 0.8885656155466812 0.10384762053805198 6.983687537223428e-05 9.12811053487095e-06 0.10055872361915633 0.03351667540725381 5.3520165761661825e-11 10.27148255014936 -0.6221222408707202 VAVPLLSSGGQVAVLELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAVPLLSSGGQVAVLELR 18 0 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 0 36547200.0 12329000.0 14574000.0 9644200.0 False True 15960133.540923113 13762944.088424368 7889054.557848512 1.0 0.8623326398325573 0.49429752812658606 23.927969387076402 -6.9540100652899905 0.5129427537133086 1.0066128005174582 0.33379012269063996 0.9994795217153375 0.004870171944834056 0.08191449961253316 0.029600225185677467 0.005581406412946316 0.030381144820290272 1.1117059618781048e-07 6.9540100652899905 -0.6728226778268183 down VAVVAGYGDVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAVVAGYGDVGK 12 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 57411000.0 20772000.0 0.0 36639000.0 False True 27232293.156334132 0.0 32847947.746105082 1.0 0.0 1.206213063201575 24.698815137080754 -10.756520406878671 6.23190249410283 1.012059595819982 0.6031065357937414 0.12614701016699792 0.49243442098722257 0.08254494178085868 0.0032250161752976556 0.47700265295341154 0.15893252596523386 1.7517801186238066e-11 10.756520406878671 -0.40895306002624066 VAVVAGYGDVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAVVAGYGDVGK 12 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 40090100.0 10125000.0 5324100.0 24641000.0 False True 9803587.41714479 7450040.894814716 18186782.885845378 1.0 0.7599300723106599 1.8551150830806913 23.224878339150703 -6.849261653748643 1.2386917342467993 0.8719695711777714 1.8982660398898754 0.939218571320174 0.11587869044594735 0.1582711049699881 0.46769338409158884 0.07321712166268232 0.16934645518851618 1.414941049392945e-07 6.849261653748643 1.0262964687121041 VAVVAGYGDVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAVVAGYGDVGK 12 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 71226000.0 12752000.0 41474000.0 17000000.0 False True 19345716.296076093 34072640.66215898 13639942.548635302 1.0 1.7612498881248435 0.7050626784701636 24.205510811326356 -6.7133295751567985 1.783641910412202 1.4664003530134762 0.7073229943840226 0.4808157296243072 0.3206239036350947 0.368394029091013 2.286672310982002 0.14295110096694694 0.36166277179074624 1.9349530194756073e-07 6.7133295751567985 -0.7590773586294536 VAVVAGYGDVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAVVAGYGDVGK 12 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 73674000.0 20772000.0 23389000.0 29513000.0 False True 28451969.742193073 22355596.642920002 22542637.2393145 1.0 0.7857310704842904 0.7923049772502998 24.762025198603645 -10.50315596824167 6.118272116412466 1.0001924945198581 0.789018023867295 0.9992723818445111 0.0026837861988922218 7.053257570692046e-06 5.727721174260774e-07 0.002600916548883323 0.0008661882710909044 3.139381045021879e-11 10.50315596824167 -0.21117447065256312 VAVVAGYGDVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAVVAGYGDVGK 12 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 27938100.0 10125000.0 11146000.0 6667100.0 False True 8419386.113553002 11085954.28569221 8061159.784812558 1.0 1.3167176485523964 0.9574522032949893 23.00528361458498 -6.673949541457254 1.9233321788346827 1.2014686429805355 0.9588752086195326 0.2966763146572585 0.13441347500435763 0.452111667005696 3.2279745923204852 0.05618673371990209 0.14935022626575298 2.1186072715225466e-07 6.673949541457254 -0.2425934343610029 VAVYVPGSK(ub)GAPSFVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAVYVPGSKGAPSFVR 16 1 Q9BY44;Q9BY44-3;F8WAE5;Q9BY44-4;C9IZE1 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 1 14778500.0 2703200.0 8018700.0 4056600.0 True False 2247830.5720648365 7975501.671512678 4904816.304400801 1.0 3.5480884416419585 2.1820222419589577 21.100101867314706 -9.935405863690582 6.035271155875568 0.9999992992661532 2.865055341800904 0.7130805924680117 0.5576941906826394 5.25931117323506e-06 9.265955534539339e-07 0.5399852793043055 0.17999502606564105 1.1603637056875516e-10 9.935405863690582 1.8650560425347509 VAYGIDSLFSFYHNKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAYGIDSLFSFYHNKPK 17 1 Q9H9F9 Q9H9F9 ACTR5 Actin-related protein 5 0 6593400.0 1897000.0 2218300.0 2478100.0 False True 2486985.370574133 1887338.2868656744 2221689.9836137164 1.0 0.7588859625780481 0.8933265188853234 21.245966590404436 -10.119662191087473 4.835567740700784 1.0000096238894025 0.82610624081858 0.6904719961581333 0.05488512728545039 5.6948190151627795e-06 1.0367277588023743e-06 0.05314523614756086 0.017714098660350237 7.59167851820222e-11 10.119662191087473 -0.17390338307082254 VAYGIDSLFSFYHNKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAYGIDSLFSFYHNKPK 17 1 Q9H9F9 Q9H9F9 ACTR5 Actin-related protein 5 0 9892100.0 3214900.0 2867800.0 3809400.0 False True 3112844.7592472862 4012927.495379436 2811603.860449631 1.0 1.2891511802695221 0.9032264947030324 21.569802199247658 -6.706197793677836 1.8089361908818389 1.1784510475585799 0.9042374481004339 0.44697065644629375 0.12192169215568804 0.382757272754822 2.4390814488430217 0.05368721634666636 0.13701422395029136 1.9669902459844372e-07 6.706197793677836 -0.27421359945814594 VAYGIDSLFSFYHNKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAYGIDSLFSFYHNKPK 17 1 Q9H9F9 Q9H9F9 ACTR5 Actin-related protein 5 0 8788300.0 1897000.0 2227000.0 4664300.0 False True 2598372.164497415 2128603.7762958184 3562688.404273867 1.0 0.8192066576835191 1.3711232182026445 21.309176651927327 -6.818461316815334 1.3784290005197963 0.9023960018954785 1.3827868093952438 0.8808142274036909 0.07931434274845905 0.19549815340114138 0.7302967290698263 0.045219634036002626 0.10427371393213967 1.5189332294009696e-07 6.818461316815334 0.48039080749976526 VAYVSFGPHAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VAYVSFGPHAGK 12 0 P50914;E7EPB3 P50914 RPL14 60S ribosomal protein L14 0 155040000.0 58706000.0 43867000.0 52467000.0 False True 76964134.50971268 37322214.59222672 47038218.13900204 1.0 0.4849299589994967 0.6111706243258791 26.197682966911497 -10.072595812314972 7.520683839508087 1.0000000479045135 0.548050291662744 0.9447182355839008 0.05153753580651633 4.141435903298768e-08 5.042458542206537e-09 0.04990100967584736 0.016633668156933838 8.460658925362704e-11 10.072595812314972 -0.4519497562417695 VAYVSFGPHAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VAYVSFGPHAGK 12 0 P50914;E7EPB3 P50914 RPL14 60S ribosomal protein L14 0 129953000.0 51833000.0 11955000.0 66165000.0 False True 50187589.78694972 16728693.844501419 48834401.59254738 1.0 0.33332331589375075 0.9730373943011265 25.58082732786408 -10.938424680028756 10.268268878747646 1.0808782503265582 0.6531803550974463 0.2815571334168079 0.26116217889547677 0.128305201613735 0.0007694017079690865 0.06709637710724438 0.08428973079345194 1.1523258911171026e-11 10.938424680028756 -0.42769789522911184 VAYVSFGPHAGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VAYVSFGPHAGK 12 0 P50914;E7EPB3 P50914 RPL14 60S ribosomal protein L14 0 79186000.0 24926000.0 33131000.0 21129000.0 False True 37814564.33469197 27218514.19631552 16952843.888830315 1.0 0.719789178460655 0.44831519778418755 25.172438661793695 -6.9715128569001905 0.21906955878088624 1.126672002129261 0.03377507505654282 0.9999918976667651 0.0006410929304488887 0.07581488798157246 0.007248084451754268 0.007573462843522272 0.027569759450716564 1.0677931810078989e-07 6.9715128569001905 -1.0928969270727182 down VAYVSFGPHAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAYVSFGPHAGK 12 0 P50914;E7EPB3 P50914 RPL14 60S ribosomal protein L14 0 153277000.0 58706000.0 44970000.0 49601000.0 False True 80411194.66999744 42983076.7040965 37886265.364660874 1.0 0.5345409539119073 0.47115660350705846 26.26089302843439 -13.999999999999998 0.28095011569771755 4.813373940904805 0.45225316407672783 0.9996072820103015 0.004672546265044973 15.449878925849486 0.1679223059583859 33.87113863364376 0.024960577907958956 1.0000000000000041e-14 13.999999999999998 -4.361120776828077 VAYVSFGPHAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VAYVSFGPHAGK 12 0 P50914;E7EPB3 P50914 RPL14 60S ribosomal protein L14 0 92262000.0 51833000.0 23810000.0 16619000.0 False True 43101436.09123879 23681730.804085054 20093956.062425923 1.0 0.5494418040724826 0.4662015441873041 25.361232603298355 -13.999999999999998 0.23749353667160997 3.9464564795629347 0.42851094571285614 0.9995208925075704 0.005132649136911292 13.536324225422117 0.15425591128976646 18.887929365650766 0.04128225816929937 1.0000000000000041e-14 13.999999999999998 -3.5179455338500785 VAYVSFGPHAGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VAYVSFGPHAGK 12 0 P50914;E7EPB3 P50914 RPL14 60S ribosomal protein L14 0 73284000.0 24926000.0 29081000.0 19277000.0 False True 32267198.364915963 27462616.78574648 15768783.798723163 1.0 0.8511001319410026 0.4886939244117493 24.943564983886144 -6.956033323015162 0.4881366355352984 1.0080665629682513 0.3164082775462295 0.9995936265260372 0.004328480151649767 0.08114972186138339 0.02660749329269694 0.005197099229250606 0.029890378231455836 1.1065388770125255e-07 6.956033323015162 -0.6916582854220217 down VAYWRQAGLSYIRYSQICAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VAYWRQAGLSYIRYSQICAK 20 2 Q5VTU8;P56381 Q5VTU8 ATP5EP2;ATP5E ATP synthase subunit epsilon-like protein, mitochondrial;ATP synthase subunit epsilon, mitochondrial 0 27641200.0 4406500.0 9892700.0 13342000.0 False True 6035702.131184958 9455607.803215807 10190894.38711529 1.0 1.5666127316590153 1.6884356062671644 22.525090178292473 -11.49934016381498 0.26875007323452166 5.891287633769234e-13 1.7351728012347105 0.999320748274984 0.007817935951008855 3.9363410561926186 0.14757832875793644 2.3357419610047145 0.05074707767612356 3.167085851895489e-12 11.49934016381498 1.7351728012341214 VCAHITNIPFSITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCAHITNIPFSITK 14 0 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 0 49963000.0 17595000.0 18669000.0 13699000.0 False True 23067215.390222378 15883657.97119204 12281558.890086899 1.0 0.6885815085389426 0.5324248584982108 24.459340520629986 -13.999999999996975 0.08947607053255541 2.598275192195723 0.1380542859240831 0.9998448605272857 0.0024208817859106063 12.16839058999621 0.0867827259999116 3.705940211205679 0.3545006409919432 1.0000000000069656e-14 13.999999999996975 -2.46022090627164 VCAHITNIPFSITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VCAHITNIPFSITK 14 0 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 0 38941900.0 20388000.0 5428900.0 13125000.0 False True 19740794.09982696 7596688.081339504 9687168.758440021 1.0 0.3848218082273647 0.4907182917492126 24.234676689509367 -10.109040410083566 5.525393147327216 1.0000067144702536 0.4377700499890463 0.9740825564379003 0.04323205836443903 3.575921858543015e-06 5.766465977558585e-07 0.04185975983125184 0.013953086838904283 7.779641599303919e-11 10.109040410083566 -0.5622366644812073 VCAHITNIPFSITK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VCAHITNIPFSITK 14 0 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 0 45334900.0 9489900.0 20160000.0 15685000.0 False True 14396872.104621416 16562290.48920105 12584852.87502027 1.0 1.1504089477800203 0.8741379921670982 23.779252066898284 -6.758856402397259 1.61666658407461 1.0874901950873619 0.8731817891252062 0.686312125317707 0.06325271060230866 0.28484911380274064 1.467027334633252 0.03087338561712597 0.07428084240501122 1.7423828895669795e-07 6.758856402397259 -0.21430840596215572 VCAHITNIPFSITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCAHITNIPFSITK 14 0 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 0 62343000.0 17595000.0 19468000.0 25280000.0 False True 24100346.986996308 18607839.38793308 19309384.657942925 1.0 0.7720984016526072 0.8012077447831595 24.522550582152878 -9.975052575303614 6.875300039453791 1.0000000191542546 0.7866530732911615 0.986230073077069 0.01188383956957626 3.4893413136055646e-09 5.237092535942417e-10 0.011506479214249694 0.0038354927284971266 1.059125500625203e-10 9.975052575303614 -0.2133469458630931 VCAHITNIPFSITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VCAHITNIPFSITK 14 0 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 0 35652700.0 20388000.0 4789700.0 10475000.0 False True 16953525.34154258 4763896.935418982 12665274.069072224 1.0 0.28099742321708304 0.747058432622122 24.015081964943644 -10.62043464619242 6.708636282229774 1.001381164501951 0.5140279280094577 0.5917854578860788 0.19026861034146955 0.0039398811415278685 0.00022291291249779347 0.18466612992187847 0.061408929929878356 2.396433344380729e-11 10.62043464619242 -0.4873532364924933 VCAHITNIPFSITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VCAHITNIPFSITK 14 0 Q9NTZ6 Q9NTZ6 RBM12 RNA-binding protein 12 0 49555900.0 9489900.0 23357000.0 16709000.0 False True 12284862.623895373 22057162.41754686 13668133.448818048 1.0 1.7954748940084457 1.112599616883958 23.550378388990733 -10.177074025870072 4.46467986863364 0.9999251608849185 1.4540372552086247 0.37084723402166575 0.27878266479306657 0.00026688229056123693 4.91906197866797e-05 0.26998704682492647 0.08997671811704075 6.651597694805637e-11 10.177074025870072 0.45411209432370625 VCALLSCTSHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCALLSCTSHK 11 0 P15121 P15121 AKR1B1 Aldose reductase 0 84378300.0 29896700.0 30835000.0 23646600.0 False True 39194863.220054634 26234538.1938886 21199876.666203983 1.0 0.6693361333243615 0.5408840578720722 25.224161254966486 -13.99999999999933 0.1308154064464278 2.571600756003604 0.3628448228567591 0.9996419401522574 0.0036595680692484913 11.935572655936637 0.11255516562359928 4.819585706057537 0.1583854390958678 1.000000000001542e-14 13.99999999999933 -2.2087559331468447 VCALLSCTSHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VCALLSCTSHK 11 0 P15121 P15121 AKR1B1 Aldose reductase 0 12679610.0 9101400.0 1433900.0 2144310.0 False True 8812481.038854474 2006463.747689718 1582650.8830788964 1.0 0.22768431941506181 0.17959197598280718 23.07111681758906 -13.607186805038207 0.39838803715517584 9.999990375670526 0.17660466256130014 0.9998277556387107 0.004933663614591754 19.17625281599133 0.20731266178962027 147.27674789008316 0.0123647915402514 2.4706611998171774e-14 13.607186805038207 -9.823385713109227 VCALLSCTSHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VCALLSCTSHK 11 0 P15121 P15121 AKR1B1 Aldose reductase 0 64607800.0 23203600.0 30930000.0 10474200.0 False True 35201557.61038511 25410299.84280696 8403969.778995054 1.0 0.7218515761163492 0.23873857719624675 25.06913593134289 -7.125928732835334 0.4371865741945148 1.0195325773676196 1.0060461001963717e-16 0.999685963191695 0.005573564011196157 0.0788890896100143 0.024535993654837183 0.00771465313555674 0.040320566097622926 7.48292284235833e-08 7.125928732835334 -1.0195325773676196 down VCALLSCTSHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCALLSCTSHK 11 0 P15121 P15121 AKR1B1 Aldose reductase 0 65084000.0 29896700.0 13594800.0 21592500.0 False True 40950317.91793876 12994136.784008242 16492796.21149654 1.0 0.31731467408989295 0.4027513594533458 25.287371316489377 -10.665485681035431 6.709618499086229 1.0036449712300002 0.3600330167755727 0.9868092906981449 0.03487938074252857 0.0019065640909602989 9.505341046285308e-05 0.03385659391178551 0.011257271728486735 2.160301260103526e-11 10.665485681035431 -0.6436119544544274 VCALLSCTSHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VCALLSCTSHK 11 0 P15121 P15121 AKR1B1 Aldose reductase 0 51872900.0 23203600.0 19279700.0 9389600.0 False True 30037517.611336138 18206767.746781632 7680789.145431912 1.0 0.6061342346050065 0.2557065215846328 24.840262253435338 -7.6733630672694 0.29792339139837304 1.1011465424250795 1.9439571575608703e-20 0.9995460857259176 0.006477415184824383 0.12567906859157718 0.04016920733801386 0.03322683723559517 0.07633633921906488 2.1214701856382552e-08 7.6733630672694 -1.1011465424250795 down VCANHWITTTMNLKPLSGSDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCANHWITTTMNLKPLSGSDR 21 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 0 14285100.0 5592000.0 3879300.0 4813800.0 False True 7331166.153005029 3300523.561392967 4315714.153230181 1.0 0.4502044412184124 0.5886804449877567 22.805611272368395 -10.227540929066654 8.230746555881339 1.0000002107805717 0.5194424431031991 0.9413750896488297 0.05653259180910227 2.1867606260099572e-07 2.0612427039193336e-08 0.054737470301667215 0.01824581554954958 5.92187274942972e-11 10.227540929066654 -0.48055776767737257 VCANHWITTTMNLKPLSGSDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VCANHWITTTMNLKPLSGSDR 21 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 0 19733200.0 6459000.0 6625400.0 6648800.0 False True 9798775.216150831 5443045.605513529 5334661.765727432 1.0 0.5554822399172938 0.5444212820531464 23.224170002224273 VCANHWITTTMNLKPLSGSDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCANHWITTTMNLKPLSGSDR 21 1 J3KNE0;A6NKT7;Q7Z3J3;F8VYC4;A0A286YES2;A0A1W2PNU4;P0DJD0;P0DJD1;P49792 J3KNE0;P49792 RGPD3;RGPD4;RGPD1;RGPD2;RANBP2 RanBP2-like and GRIP domain-containing protein 3;RanBP2-like and GRIP domain-containing protein 4;RANBP2-like and GRIP domain-containing protein 1;RANBP2-like and GRIP domain-containing protein 2;E3 SUMO-protein ligase RanBP2 0 18135200.0 5592000.0 5044300.0 7498900.0 False True 7659513.518117835 4821426.146730577 5727814.264693367 1.0 0.6294689780657691 0.7478039239887467 22.868821333891287 -10.762091965644208 10.216443747932397 1.0011552971941997 0.6886364510272581 0.9022577389648458 0.04831003937518931 0.0012750315949642088 2.9691287658570806e-05 0.046914918986136936 0.015591998162894395 1.7294500942958452e-11 10.762091965644208 -0.3125188461669416 VCASEK(ub)PPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCASEKPPK 9 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 6237500.0 1585400.0 3029700.0 1622400.0 True False 2078474.753035437 2577680.5696781017 1454529.6111597186 1.0 1.2401789176960734 0.6998062444759076 20.987093793162433 -6.785865978462571 1.5126511246264422 1.1349621132435306 0.6946836064720963 0.7876928428521262 0.10185704185413029 0.24157519862544347 1.0919796427880286 0.05301349920907176 0.12450998137086183 1.637321714395856e-07 6.785865978462571 -0.4402785067714343 VCASEK(ub)PPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VCASEKPPK 9 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 3720890.0 1549200.0 1290000.0 881690.0 True False 1500021.493989207 1805103.7272611314 650748.9388669705 1.0 1.2033852411411643 0.43382640947120504 20.516551742744976 -6.8364237152224385 1.2987182014508059 1.1083034488435701 0.4102287436035033 0.9181485691734169 0.09315317897464957 0.1730264581180311 0.5684080119432747 0.05627086021690755 0.12955218488463247 1.4573916762907914e-07 6.8364237152224385 -0.6980747052400669 down VCASEK(ub)PPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCASEKPPK 9 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 5440100.0 1585400.0 1694100.0 2160600.0 True False 2171565.2238240354 1619249.0603604584 1650310.7789537783 1.0 0.7456598782278474 0.7599637168841975 21.050303854685325 -10.475344776713525 9.135566385739391 1.0000039811186185 0.7528117975575619 0.9974949170788374 0.005839517678525847 4.7351070722329793e-07 2.718871734024106e-08 0.005654179718043097 0.001884696226567872 3.346996230850735e-11 10.475344776713525 -0.24719218356105666 VCASEK(ub)PPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VCASEKPPK 9 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 3147980.0 1549200.0 543380.0 1055400.0 True False 1288228.4411966738 540452.7040875145 1276079.2603817505 1.0 0.41953172807260175 0.9905690788788691 20.296957018179253 -10.889584974756154 11.078385527239394 1.0176411782715404 0.7050504035070141 0.26238324137716507 0.2331250222576719 0.08953754999766605 0.0008923928632893084 0.1989686510016684 0.07524077739901643 1.2894812312445906e-11 10.889584974756154 -0.31259077476452635 VCASEKPPK(ub)DLGYIYFYQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VCASEKPPKDLGYIYFYQR 19 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 13639000.0 5740100.0 4284600.0 3614300.0 True False 5557883.667471887 5995463.123893824 2667606.4033241738 1.0 1.078731309002187 0.47996801713152576 22.406104207008052 -6.873796942576529 1.1137673815674156 1.045737252637831 0.44226778597953753 0.9683302016250295 0.04727584765012859 0.13326875657316103 0.30667386623103565 0.032859188574840915 0.07835372910787947 1.3372205972504748e-07 6.873796942576529 -0.6034694666582935 down VCASVTFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCASVTFK 8 0 P55060-3;P55060;P55060-4;P55060-2 P55060-3 CSE1L Exportin-2 0 51410000.0 12939000.0 13961000.0 24510000.0 False True 16963154.301454224 11878073.219551759 21973940.316521626 1.0 0.7002278590682555 1.2953923501502216 24.015901128448615 -6.769753734455274 1.5752430667242445 0.8280047113350849 1.298720892798693 0.7296692486283765 0.12633190128660632 0.2668295873500345 1.3066315030432618 0.06321376416782698 0.1505184116417958 1.6992069101427925e-07 6.769753734455274 0.47071618146360816 VCASVTFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCASVTFK 8 0 P55060-3;P55060;P55060-4;P55060-2 P55060-3 CSE1L Exportin-2 0 33502100.0 12939000.0 8445100.0 12118000.0 False True 17722897.963327363 8071967.557788857 9255977.978044005 1.0 0.4554541573557305 0.5222609754452512 24.079111189971506 -10.37613522802286 5.857450028052101 1.0001133144278391 0.48885756640113603 0.9873500117906688 0.027273769276379606 4.0367864843532734e-05 4.2994903330532695e-06 0.026413505650437447 0.008802571182976443 4.2059564543220955e-11 10.37613522802286 -0.511255748026703 VCASVTFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VCASVTFK 8 0 P55060-3;P55060;P55060-4;P55060-2 P55060-3 CSE1L Exportin-2 0 45426000.0 11147000.0 19113000.0 15166000.0 False True 14430011.24021978 18049344.748322703 12405943.61630105 1.0 1.250819867555959 0.8597320826558205 23.78256908782464 -6.733463138060449 1.710576508188227 1.1503465666552541 0.8598084519558163 0.5754158199278798 0.10541167093587743 0.32970352359025645 1.891516860211612 0.04880389153910716 0.12063287054756826 1.847297582722649e-07 6.733463138060449 -0.2905381146994378 VCDLIMTAIK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCDLIMTAIKR 11 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 19102100.0 5692500.0 7780000.0 5629600.0 True False 7462922.626248414 6619254.326202468 5047102.994936354 1.0 0.8869520237180786 0.676290408959193 22.831309298016944 -6.961404226175702 0.41517659583363736 1.0098095461599517 0.545548806814102 0.9998187688976118 0.0018058350814617687 0.07920335542346585 0.019306265469502582 0.0027178509847412724 0.017560324320228138 1.0929386235060715e-07 6.961404226175702 -0.46426073934584966 VCDLIMTAIK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 VCDLIMTAIKR 11 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 38508000.0 12861000.0 14743000.0 10904000.0 True False 19511077.265043482 12111996.462415256 8748819.620607028 1.0 0.6207753830238477 0.44840269462115373 24.217790099874012 -13.999999999990278 0.10619588266634356 2.8434849435177165 0.11414221677486336 0.9997624016578902 0.003551528717035886 12.036340155895036 0.09824366382949944 4.7934746476490355 0.2972434122788052 1.0000000000223857e-14 13.999999999990278 -2.7293427267428534 VCDLIMTAIK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCDLIMTAIKR 11 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 18735800.0 5692500.0 7178200.0 5865100.0 True False 7797171.084028214 6861043.388866926 4479884.175526156 1.0 0.8799400853113433 0.5745525046516916 22.894519359539835 -6.955090035915149 0.4998544664786084 1.00612368679924 0.4352006151205977 0.9995425383744319 0.0038305848347987862 0.08150401765064226 0.027985177669866343 0.004493517630872416 0.025191577981221538 1.1089448901249751e-07 6.955090035915149 -0.5709230716786423 VCDLIMTAIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VCDLIMTAIKR 11 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 9650580.0 3502300.0 884080.0 5264200.0 True False 2912317.628197208 879317.2855638586 6364919.881089272 1.0 0.3019304203120785 2.185517067047836 21.47373627913116 -6.806371900421798 1.429826441332592 0.6178970791767007 2.215773787908481 0.8501151868016378 0.3010114219187947 0.21179241535261992 0.8540495914230208 0.16557142950622353 0.3836515040327974 1.5618096416882011e-07 6.806371900421798 1.5978767087317804 VCDLIMTAIK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VCDLIMTAIKR 11 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 36968000.0 12861000.0 14443000.0 9664000.0 True False 16648818.028210886 13639234.353582636 7905251.161013672 1.0 0.8192313911096507 0.47482356691138544 23.98891642196646 -6.960982937714477 0.42135191303857134 1.0150037048743334 0.2660304663293399 0.9998049346935617 0.0030425306742718526 0.07935184624028695 0.019847625052980513 0.00445917511036436 0.028658712878542762 1.093999345778651e-07 6.960982937714477 -0.7489732385449935 down VCEGPK(ub)AVAAPRPDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCEGPKAVAAPRPDR 15 2 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 5916200.0 2052900.0 2462600.0 1400700.0 True False 2691371.7803118816 2095189.6791396164 1255769.0004631525 1.0 0.7784839294468717 0.46659068421889727 21.359910264860048 -6.966287783196882 0.3352155635700889 1.0357602599900104 0.19902390856419355 0.9999372825024627 0.0017327861373789373 0.07752663243778579 0.013333746180066625 0.004470280482880647 0.027092679028629246 1.0807175815495007e-07 6.966287783196882 -0.8367363514258168 down VCEGPK(ub)AVAAPRPDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VCEGPKAVAAPRPDR 15 2 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 8341900.0 2688600.0 3528400.0 2124900.0 True False 2603251.864665237 4937308.52036292 1568324.9443664174 1.0 1.8965927144348091 0.6024484091047007 21.311883468590292 -6.7203815977476955 1.7583322718550345 1.545261287743161 0.6044750702476259 0.5141713098779768 0.3772711419034034 0.35456210391256116 2.1426414556164572 0.17036639141856852 0.4274285341061402 1.9037871987355387e-07 6.7203815977476955 -0.9407862174955351 VCEGPK(ub)AVAAPRPDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VCEGPKAVAAPRPDR 15 2 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 13512800.0 2911500.0 2787500.0 7813800.0 True False 4416958.35916135 2290048.8461630917 6269399.0050897915 1.0 0.5184673841022818 1.4193928254012713 22.074621800770704 -6.761524748267591 1.6068046388529664 0.7208252544258934 1.422924810163643 0.6971139549292581 0.2025801700017027 0.28037364684826105 1.4270329507888708 0.0994603695303544 0.23865340273696473 1.731710346438086e-07 6.761524748267591 0.7020995557377495 VCEGPK(ub)AVAAPRPDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCEGPKAVAAPRPDR 15 2 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 5851900.0 2052900.0 1842500.0 1956500.0 True False 2811912.607536502 1761092.257667286 1494414.9953823327 1.0 0.6262969385845057 0.5314585493791643 21.42312032638294 -13.999999999999998 0.19255406808598405 3.02126687564367 0.46514171640382174 0.9994882053304425 0.004575683906991624 12.393446944009806 0.13915679618509494 9.407231513856487 0.06392122006202511 1.0000000000000041e-14 13.999999999999998 -2.556125159239848 VCENIPIVLCGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCENIPIVLCGNK 13 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 67594100.0 2918100.0 33196000.0 31480000.0 False True 3825657.358920594 28243286.19699451 28222751.57748271 1.0 7.382596910080658 7.3772293045725705 21.86727623529196 -10.062557174999897 4.830614248202844 0.9998111555202105 7.379913107409733 0.9999994691206745 0.0021913160570937533 91116.82907677627 94902.23103809658 152.80692657126636 0.0007501457225003769 8.658503263990114e-11 10.062557174999897 6.380101951889523 VCENIPIVLCGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCENIPIVLCGNK 13 0 B5MDF5;P62826;J3KQE5;F5H018;B4DV51 B5MDF5 RAN GTP-binding nuclear protein Ran 0 73184100.0 2918100.0 27266000.0 43000000.0 False True 3997000.428687346 26061297.96339551 32844285.612798557 1.0 6.520213952529971 8.217233447629361 21.930486296814852 -9.107290597089685 0.4439792208365716 5.994183695911122e-22 8.369350574232858 0.9974267110550077 0.15629908195945946 0.5346978285230145 0.17167390733190332 1.4269807966972783 0.3831907181176687 7.811049731926314e-10 9.107290597089685 8.369350574232858 VCEVCSAYLGLHDNDRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCEVCSAYLGLHDNDRR 17 1 A8MYV2;Q9NQ29-2;Q9NQ29-3;Q9NQ29;B8ZZ10;Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 A8MYV2;Q9Y383 LUC7L;LUC7L2 Putative RNA-binding protein Luc7-like 1;Putative RNA-binding protein Luc7-like 2 0 17821500.0 5372100.0 6518400.0 5931000.0 False True 7042875.123490395 5545880.128524197 5317317.01416931 1.0 0.7874454723791413 0.7549923746957036 22.74773307199771 -13.99999999908909 0.264596387480269 2.5940088886923975 0.7436429964730014 0.9995718452804776 0.0022483575735289005 14.625169733215321 0.16279603353118538 12.499643270208528 0.013852600226385832 1.0000000020974488e-14 13.99999999908909 -1.8503658922193962 VCFEMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCFEMK 6 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;M0QYG9;M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;Q9BUJ2-3;M0QYZ0;M0QYM5;M0QYI8 Q00839;M0R3F1 HNRNPU;HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U;Heterogeneous nuclear ribonucleoprotein U-like protein 1 0 40700000.0 11388000.0 14014000.0 15298000.0 False True 14929778.281548882 11923165.826144142 13715109.708777964 1.0 0.798616402822238 0.9186412182509047 23.831689404735226 -10.241332134864034 5.0544710574303915 1.0000206869034032 0.8586288105620086 0.6490948708868671 0.04899992571226465 1.1424397794008002e-05 1.7147518666226253e-06 0.04745091427325061 0.01581465802071133 5.7367756370637804e-11 10.241332134864034 -0.1413918763413946 VCFEMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VCFEMK 6 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;M0QYG9;M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;Q9BUJ2-3;M0QYZ0;M0QYM5;M0QYI8 Q00839;M0R3F1 HNRNPU;HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U;Heterogeneous nuclear ribonucleoprotein U-like protein 1 0 11642900.0 6635700.0 1784800.0 3222400.0 False True 6425053.335698547 2497479.947609044 2378356.7700721635 1.0 0.38870960552695744 0.370169187056808 22.615276999790755 VCFEMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VCFEMK 6 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;M0QYG9;M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;Q9BUJ2-3;M0QYZ0;M0QYM5;M0QYI8 Q00839;M0R3F1 HNRNPU;HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U;Heterogeneous nuclear ribonucleoprotein U-like protein 1 0 41499700.0 5040200.0 31192000.0 5267500.0 False True 7646351.8879769975 25625543.89579167 4226376.316172729 1.0 3.3513424795535327 0.5527310772628993 22.866340164390493 -6.683871947887313 1.8879068877262355 2.4825075626113366 0.5629838540725745 0.34200413653370176 0.9957207869453941 0.4299944577595465 2.966267744505408 0.42267414769267525 1.1093665957048862 2.0707518217962918e-07 6.683871947887313 -1.9195237085387622 VCFEMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCFEMK 6 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;M0QYG9;M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;Q9BUJ2-3;M0QYZ0;M0QYM5;M0QYI8 Q00839;M0R3F1 HNRNPU;HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U;Heterogeneous nuclear ribonucleoprotein U-like protein 1 0 32947500.0 11388000.0 9580500.0 11979000.0 False True 15598451.349128393 9157201.83152316 9149806.915249145 1.0 0.5870583961551313 0.5865843159975247 23.894899466258117 VCFEMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VCFEMK 6 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;M0QYG9;M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;Q9BUJ2-3;M0QYZ0;M0QYM5;M0QYI8 Q00839;M0R3F1 HNRNPU;HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U;Heterogeneous nuclear ribonucleoprotein U-like protein 1 0 10775600.0 6635700.0 1489500.0 2650400.0 False True 5517878.561353456 1481475.7678573998 3204586.38593499 1.0 0.2684864756237069 0.580764210430349 22.39568227522503 -10.506698235945489 6.258256887353346 1.0004706971476363 0.4246253430288473 0.8190521586669139 0.12748685138473922 0.0008379096872555083 6.604733787410687e-05 0.12353388093135892 0.04114620435612624 3.113879225378122e-11 10.506698235945489 -0.5758453541187889 VCFEMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VCFEMK 6 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;M0QYG9;M0R3F1;A0A0A0MRA5;B7Z4B8;Q9BUJ2-4;Q9BUJ2-2;Q9BUJ2;Q9BUJ2-3;M0QYZ0;M0QYM5;M0QYI8 Q00839;M0R3F1 HNRNPU;HNRNPUL1 Heterogeneous nuclear ribonucleoprotein U;Heterogeneous nuclear ribonucleoprotein U-like protein 1 0 12507400.0 5040200.0 5507600.0 1959600.0 False True 6524638.257195281 5201097.2184305005 1602972.9071939555 1.0 0.797147215432948 0.24567996630713115 22.637466486482943 -6.953642187693129 0.5173203728703437 1.0095687152488584 0.00876092896648116 0.9994569580853231 0.007427302661003552 0.08205544268477856 0.030159081034867752 0.008450533445816883 0.04553996171653847 1.1126480530106609e-07 6.953642187693129 -1.0008077862823772 down VCFEMK(ub)VTEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCFEMKVTEK 10 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 4971700.0 1789800.0 2054700.0 1127200.0 True False 2346445.132447857 1748146.769157868 1010568.1568658995 1.0 0.7450192399488018 0.43068049744323456 21.162045295161967 -6.968312128082733 0.29573708587816655 1.057353790395381 0.10855570628196386 0.9999660598704411 0.0013564964304132582 0.07685428299713323 0.01098017330605336 0.0053284716004813985 0.028321694482061958 1.0756918344456267e-07 6.968312128082733 -0.948798084113417 down VCFEMK(ub)VTEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VCFEMKVTEK 10 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 5875700.0 2489000.0 1499400.0 1887300.0 True False 2069713.7813958963 1491322.4345924035 2281925.704110745 1.0 0.720545250264796 1.102532014147253 20.980999842019305 -6.710600895005093 1.7931976296169971 0.8283029462051086 1.1016457725373139 0.46791919271803906 0.11774948616488781 0.3738562505015559 2.3437998839730296 0.05224962673789882 0.13263528040419933 1.9471486371164268e-07 6.710600895005093 0.2733428263322053 VCFEMK(ub)VTEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VCFEMKVTEK 10 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 14191400.0 3564400.0 6631400.0 3995600.0 True False 4614186.064828159 6262356.7605309095 3268441.7983181113 1.0 1.3571964096259588 0.7083463372298651 22.137644750499934 -6.757246315394386 1.6227927187016011 1.2081883663360984 0.7062897795550279 0.6796400327223986 0.15018452055950662 0.28756980690081824 1.491908958816981 0.07304237547177748 0.1760159495209017 1.7488545231912535e-07 6.757246315394386 -0.5018985867810705 VCFVTSMMTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCFVTSMMTGR 11 0 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7;B4DSP0;A0A087WZG9;Q86TG7-2 A0A087WUL4;B4DSP0 PEG10 Retrotransposon-derived protein PEG10 0 15474700.0 4712300.0 5692200.0 5070200.0 False True 6177870.933978116 4842945.948021817 4545584.340792656 1.0 0.7839182786072384 0.7357849313089515 22.558678300300286 -13.999999997525382 0.21101451243025462 2.2549177791813055 0.7077116741674043 0.9994906032239953 0.002593261990199017 12.77064888964048 0.14559187199534682 6.647627724247167 0.028310546123400542 1.0000000056980182e-14 13.999999997525382 -1.5472061050139012 VCFVTSMMTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCFVTSMMTGR 11 0 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7;B4DSP0;A0A087WZG9;Q86TG7-2 A0A087WUL4;B4DSP0 PEG10 Retrotransposon-derived protein PEG10 0 13030600.0 4712300.0 4103000.0 4215300.0 False True 6454564.655119224 3921715.8931934154 3219732.9568285923 1.0 0.6075879788550939 0.4988303826618218 22.621888361823178 -13.999999999999998 0.18003563524686117 3.036268518656151 0.41247035345610517 0.9994980947598414 0.004822255772061265 12.205195488356436 0.1345083294981826 8.693879816044044 0.08117773023091956 1.0000000000000041e-14 13.999999999999998 -2.623798165200046 VCHAHPTLSEAFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCHAHPTLSEAFR 13 0 P09622;E9PEX6;P09622-2;P09622-3 P09622 DLD Dihydrolipoyl dehydrogenase, mitochondrial;Dihydrolipoyl dehydrogenase 0 4967160.0 818060.0 2581200.0 1567900.0 False True 1072484.5821043104 2196095.021438795 1405668.7483588026 1.0 2.0476704822458713 1.3106656933013947 20.03252547720607 -10.234902621650086 4.955497026212376 0.9998902228205653 1.679168087774234 0.5310177656279054 0.30088094515259584 0.0003649994434701143 5.635486569819329e-05 0.29137334598544046 0.09710890748026257 5.822337527156834e-11 10.234902621650086 0.6792778649536688 VCIESEHSMDTLLATLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCIESEHSMDTLLATLK 17 0 E5RGN3;E5RIM7;O00244 E5RGN3 ATOX1 Copper transport protein ATOX1 0 14445400.0 1878200.0 9453000.0 3114200.0 False True 2462338.388514671 8042649.247505407 2791972.4575157734 1.0 3.2662648176300757 1.1338703366436746 21.23159760811058 -6.631785635422272 2.0735902461045814 2.4910645822443533 1.142438799089742 0.12409899485432252 0.9716595989027372 0.5543629380674164 4.544616536314774 0.38291014647562943 1.0765274697582736 2.3346101244036236e-07 6.631785635422272 -1.3486257831546113 VCIESEHSMDTLLATLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VCIESEHSMDTLLATLK 17 0 E5RGN3;E5RIM7;O00244 E5RGN3 ATOX1 Copper transport protein ATOX1 0 9622900.0 3912100.0 3050000.0 2660800.0 False True 3787912.52687527 4267880.905539879 1963856.6577110277 1.0 1.1267105233447787 0.5184535397207429 21.852971584792467 -6.852342382275654 1.2237056277177836 1.0677782831572813 0.49301257696882583 0.9436494844347018 0.062200446626721896 0.15489821770046153 0.44517481831675126 0.03974850169293227 0.09213037311309555 1.4049394832513427e-07 6.852342382275654 -0.5747657061884555 VCIESEHSMDTLLATLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCIESEHSMDTLLATLK 17 0 E5RGN3;E5RIM7;O00244 E5RGN3 ATOX1 Copper transport protein ATOX1 0 14973200.0 1878200.0 4966900.0 8128100.0 False True 2572621.296446515 4747445.934658145 6208410.183474131 1.0 1.845373021367603 2.4132623764133583 21.29480766963347 -8.19566603951923 0.14544580882347122 3.086863006358477e-16 3.562335921603325 0.9999375205296207 0.00458974011856614 0.0872798273866722 0.029525404376204753 0.31582994382200613 0.33589329369242815 6.372853874264311e-09 8.19566603951923 3.5623359216033244 VCIESEHSMDTLLATLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VCIESEHSMDTLLATLK 17 0 E5RGN3;E5RIM7;O00244 E5RGN3 ATOX1 Copper transport protein ATOX1 0 8886200.0 3912100.0 1442600.0 3531500.0 False True 3253084.485415376 1434828.4274663199 4269920.322188882 1.0 0.44106706539566287 1.312575907982811 21.633376860226743 -6.73350555902023 1.7105361726968085 0.6649557433145733 1.312390076678293 0.575407327174702 0.23490410902505487 0.3297023926564049 1.891461214327101 0.10875978501331403 0.2688065247802097 1.847117151442424e-07 6.73350555902023 0.6474343333637197 VCIGAVWHPHETSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCIGAVWHPHETSK 14 0 O60508 O60508 CDC40 Pre-mRNA-processing factor 17 0 8292600.0 3726000.0 2646600.0 1920000.0 False True 4884822.082635329 2251737.5963660004 1721336.8179404929 1.0 0.46096614334645386 0.35238475195637897 22.219874585934598 -13.999999999999998 0.22524553075683793 4.32958964562952 0.29714522757472683 0.9995036825065616 0.0063088853003552495 13.147660830192784 0.15030854093512758 19.526697816913305 0.058079019977953186 1.0000000000000041e-14 13.999999999999998 -4.032444418054793 VCIGAVWHPHETSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VCIGAVWHPHETSK 14 0 O60508 O60508 CDC40 Pre-mRNA-processing factor 17 0 6503400.0 1217100.0 1774600.0 3511700.0 False True 1846429.6819286563 1457908.7649869167 2817610.9557672115 1.0 0.78958260867215 1.5259779364162542 20.81630689037595 -6.830347674655386 1.3265321149658191 0.8875977044825748 1.5459099729079429 0.9065348722453662 0.09468056894340943 0.18038410543428135 0.6206958953190068 0.05604103951352576 0.12895313861683602 1.4779247610798332e-07 6.830347674655386 0.658312268425368 VCIGAVWHPHETSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCIGAVWHPHETSK 14 0 O60508 O60508 CDC40 Pre-mRNA-processing factor 17 0 9862170.0 3726000.0 3026170.0 3110000.0 False True 5103602.891363926 2892463.803194035 2375482.0524605443 1.0 0.5667493856327506 0.4654519763832374 22.28308464745749 -13.99999999999994 0.20416359177177917 3.4474894027789578 0.4022993571232974 0.9994875797300967 0.005247877024524804 12.616305254657508 0.14325217188412107 12.352846854547444 0.06255437901252638 1.000000000000139e-14 13.99999999999994 -3.0451900456556604 VCIGAVWHPHETSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VCIGAVWHPHETSK 14 0 O60508 O60508 CDC40 Pre-mRNA-processing factor 17 0 7852000.0 1217100.0 3462000.0 3172900.0 False True 1575559.9426277499 3269336.6566574196 2595464.7567032585 1.0 2.075031592390421 1.6473284744561931 20.5874332124684 -10.16267573075929 5.608782268209863 0.9999826735831668 1.8611800334233797 0.8438859627691808 0.17460906672297305 3.7832984992830646e-05 5.648002315448806e-06 0.16906789429359328 0.05635483395953665 6.875816363986973e-11 10.16267573075929 0.8611973598402128 VCISILHAPGDDPMGYESSAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCISILHAPGDDPMGYESSAER 22 0 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 0 20087200.0 5141900.0 7565300.0 7380000.0 False True 6741080.694230436 6436586.729308431 6616388.39395877 1.0 0.9548300964291058 0.9815026245897949 22.684548464474037 -10.488810738529041 5.8128509775398145 1.000033995220459 0.9681663605094672 0.6550835764721625 0.010889014023950616 4.802443321882453e-06 4.2233960287283425e-07 0.010554500080536643 0.003514414164281642 3.244809923220326e-11 10.488810738529041 -0.031867634710991855 VCISILHAPGDDPMGYESSAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCISILHAPGDDPMGYESSAER 22 0 P60604-2;P60604 P60604-2 UBE2G2 Ubiquitin-conjugating enzyme E2 G2 0 38231900.0 5141900.0 13613000.0 19477000.0 False True 7042999.3846227 13011532.647828888 14876933.741406433 1.0 1.8474419685791197 2.1123008719676903 22.74775852599693 -10.598890278296167 0.24352537124737647 6.831020180798716e-10 2.256051720008137 0.9991927884088647 0.013478476747890673 2.304920465010149 0.1230608966265507 1.5064719147391012 0.1247957001547247 2.5183130829767408e-11 10.598890278296167 2.256051719325035 VCIVGSGNWGSAIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCIVGSGNWGSAIAK 15 0 P21695-2;P21695 P21695-2 GPD1 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic 0 11658700.0 3645300.0 4093500.0 3919900.0 False True 4779023.601135414 3482765.7563380217 3514306.350335903 1.0 0.7287609451249784 0.7353607438768379 22.188284461653677 -10.105523830755857 4.895932274027601 1.0000109157119053 0.7320608445006701 0.9995451641375369 0.002694356567804674 713460.2283754199 1472628.4802698626 56.04832523226229 0.0009223499515207951 7.842890819215395e-11 10.105523830755857 -0.26795007121123515 VCIVGSGNWGSAIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCIVGSGNWGSAIAK 15 0 P21695-2;P21695 P21695-2 GPD1 Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic 0 10887000.0 3645300.0 2577100.0 4664600.0 False True 4993065.920528424 2463235.2006699345 3562917.5504525574 1.0 0.4933311996828687 0.7135731046137457 22.251494523176568 -10.298578302282326 5.718816529424256 1.0000386361281788 0.6034521521483046 0.8121166150236052 0.08991338117654676 4.42963205288337e-05 5.433021252598767e-06 0.08706671618917208 0.02901941899149541 5.0283059849281116e-11 10.298578302282326 -0.39658648397987417 VCK(ub)DMNLTLEPEIMPAATDNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCKDMNLTLEPEIMPAATDNR 21 1 Q03154;A0A1B0GU86;A0A1B0GW23;Q03154-4;C9JMV9;Q03154-2;Q03154-3 Q03154 ACY1;ABHD14A-ACY1 Aminoacylase-1 1 9119390.0 979090.0 2367600.0 5772700.0 True False 1283596.4715210483 2014363.3088325176 5175396.379648484 1.0 1.5693119711099845 4.03194967770182 20.2917602982369 -6.943080623795789 0.6302516739957034 0.9731364704358694 4.760905427689725 0.9985402115309683 0.050272121867708706 0.08638890258897804 0.0484175638714651 0.050164556525496264 0.20924841211038026 1.1400381276456628e-07 6.943080623795789 3.7877689572538555 VCK(ub)DMNLTLEPEIMPAATDNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VCKDMNLTLEPEIMPAATDNR 21 1 Q03154;A0A1B0GU86;A0A1B0GW23;Q03154-4;C9JMV9;Q03154-2;Q03154-3 Q03154 ACY1;ABHD14A-ACY1 Aminoacylase-1 1 76381200.0 4579200.0 16050000.0 55752000.0 True False 6946981.1843625875 13185752.100777648 44732592.76303033 1.0 1.8980549609747492 6.439141200457234 22.72795475917519 -6.939554434936773 0.6636949931878328 0.9486165694184746 7.647844618138799 0.9981049670392609 0.10363924904235915 0.08797046752053758 0.055539588204174345 0.1005477234264538 0.3916156928406258 1.1493321758619824e-07 6.939554434936773 6.699228048720324 VCLDIIYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCLDIIYK 8 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 9060000.0 2232200.0 3530300.0 3297500.0 False True 2926435.816655551 3003593.0010016216 2956306.331853531 1.0 1.0263655822919255 1.0102071314969474 21.480713206779843 -10.223881770750864 4.843571475054141 0.9999968162497229 1.0182863568944724 0.6306730893991803 0.006596659913720635 2.268333301295941e-07 3.634563464092626e-08 0.006388300544795804 0.0021290628321848446 5.971978413606313e-11 10.223881770750864 0.018289540644749525 VCLDIIYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCLDIIYK 8 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 7137100.0 2232200.0 2252700.0 2652200.0 False True 3057504.662936811 2153168.2653172817 2025804.9837735845 1.0 0.7042240332183529 0.662568076618319 21.543923268302734 -13.999999999952985 0.2761322724475007 3.3599625758487295 0.6495423800181851 0.9995966526395917 0.0030168242353622054 15.192996742709933 0.16641090716088092 20.201713387610596 0.016786514702497823 1.0000000001082557e-14 13.999999999952985 -2.7104201958305443 VCLLGCGISTGYGAAVNTAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCLLGCGISTGYGAAVNTAK 20 0 P11766;H0YAG8 P11766 ADH5 Alcohol dehydrogenase class-3 0 20273300.0 4973300.0 9647500.0 5652500.0 False True 6520044.461505709 8208130.605660461 5067633.522608662 1.0 1.2589071522627182 0.777239105120821 22.63645037184419 -6.760664398931511 1.609675048253694 1.1502576182861863 0.7754017933728011 0.6938295242817604 0.10890833332551199 0.28178042446790624 1.4390724652706852 0.053376354432851186 0.12820284294909204 1.7351443126212078e-07 6.760664398931511 -0.3748558249133852 VCLLGCGISTGYGAAVNTAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VCLLGCGISTGYGAAVNTAK 20 0 P11766;H0YAG8 P11766 ADH5 Alcohol dehydrogenase class-3 0 29351400.0 4678200.0 16580000.0 8093200.0 False True 7097171.422232062 13621169.459868725 6493575.472624431 1.0 1.9192391798794772 0.9149526038335708 22.758812722363036 -6.665903911903324 1.9516382288587821 1.5887826908447276 0.9190506471785663 0.2611801518107172 0.39084163221441354 0.4705650865478024 3.451300281493146 0.16144231631253397 0.43369069562326545 2.1582218651188403e-07 6.665903911903324 -0.6697320436661612 VCLLGCGISTGYGAAVNTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCLLGCGISTGYGAAVNTAK 20 0 P11766;H0YAG8 P11766 ADH5 Alcohol dehydrogenase class-3 0 22220000.0 4973300.0 6278700.0 10968000.0 False True 6812063.408379013 6001286.273115642 8377584.293050564 1.0 0.8809792148637234 1.229815958956859 22.699660433367082 -6.814604334074496 1.3949084815738726 0.935478526511171 1.2365945751429073 0.8715636586265552 0.051888639619490654 0.20057941178168046 0.7682578310254197 0.02924105270896895 0.06751660224653973 1.532483001355306e-07 6.814604334074496 0.30111604863173624 VCLLGCGISTGYGAAVNTAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VCLLGCGISTGYGAAVNTAK 20 0 P11766;H0YAG8 P11766 ADH5 Alcohol dehydrogenase class-3 0 16642500.0 4678200.0 7131600.0 4832700.0 False True 6056022.121108488 6734720.190819776 3953198.187689448 1.0 1.112069945607639 0.6527714246469526 22.529939044455485 -6.842220880848871 1.2721727004927155 1.059609528319672 0.6370009276481648 0.9281842922533386 0.05239860800978153 0.16622245017131912 0.5216283721730495 0.032285773633328164 0.07442482531913194 1.438066995743455e-07 6.842220880848871 -0.4226086006715072 VCLNLPYFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCLNLPYFLR 10 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 0 6300890.0 2029400.0 3468200.0 803290.0 False True 2660563.052737553 2950758.078937718 720173.2565017802 1.0 1.1090727866425012 0.27068452888600664 21.34330016370912 -6.874185242894365 1.111782566658119 1.0635540392894118 0.21752960000588653 0.9686815524782021 0.06586558934678961 0.13290210052492002 0.3045126807981189 0.04585234786473357 0.10941308410478329 1.3360255299689923e-07 6.874185242894365 -0.8460244392835253 down VCLNLPYFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCLNLPYFLR 10 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 0 15914600.0 2029400.0 5320100.0 8565100.0 False True 2779724.022472876 5085040.390781931 6542199.783771647 1.0 1.8293328221332623 2.3535429168078443 21.40651022523201 -8.605135748839105 0.15051295245210344 1.6686554120032474e-20 3.2983390847161815 0.9998836045863826 0.006011897362111642 0.20832931955612857 0.040343591124236106 0.4402327541744257 0.3550912944209462 2.4823570655933802e-09 8.605135748839105 3.2983390847161815 VCLYLTSCVNYVPEPENSALLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VCLYLTSCVNYVPEPENSALLR 22 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 81713000.0 18122000.0 32550000.0 31041000.0 False True 27492398.89566268 26741198.18568925 24905732.744246382 1.0 0.9726760581052116 0.9059134067844338 24.712529461345397 -6.955951095775946 0.4891742556441143 1.0014720434300601 0.8742903666545799 0.99958927603159 0.0008008947954421155 0.08118054345081323 0.026726958496306324 0.0009595378552633202 0.00550638896881624 1.1067484036237513e-07 6.955951095775946 -0.1271816767754802 VCLYLTSCVNYVPEPENSALLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VCLYLTSCVNYVPEPENSALLR 22 0 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 43050100.0 18122000.0 7530100.0 17398000.0 False True 23459286.23802484 7111043.315510115 14231742.518555049 1.0 0.3031227482097866 0.6066570983513987 24.483655783437847 -10.485002453527027 6.215752769801683 1.000343073192874 0.454889923281122 0.8113288645939054 0.12391737954237286 0.000589491105957549 4.884140151786098e-05 0.12005508806652844 0.03999416227277277 3.2733884558761576e-11 10.485002453527027 -0.545453149911752 VCMDFNIIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCMDFNIIR 9 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 9081600.0 2144700.0 3346600.0 3590300.0 False True 2811722.4693043474 2847300.3249446293 3218810.1965894587 1.0 1.0126534023285323 1.144782328885336 21.423022769738182 -6.925499667017368 0.7828503411168102 0.9976206283455594 1.169040344771763 0.9955773390765208 0.004354133844568093 0.09504310454538137 0.08962818278935081 0.003865317089519017 0.012264523184109881 1.1871356112448688e-07 6.925499667017368 0.17141971642620357 VCMDFNIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCMDFNIIR 9 0 A0A0A0MSX9;P41252;J3KR24 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 8511500.0 2144700.0 2728800.0 3638000.0 False True 2937653.5483382237 2608232.5930651193 2778779.326961886 1.0 0.887862557700362 0.9459179856432662 21.486232831261074 -10.1131768098017 4.384255006634304 1.000009626739497 0.916890271738969 0.7320815199820184 0.023701029237227774 33038976.788569644 0.3874746623971107 3586.936181263049 0.00811349271416273 7.705896830204721e-11 10.1131768098017 -0.08311935500052792 VCMYFTYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCMYFTYK 8 0 E5RHG8;Q15369;Q15369-2 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 0 77454000.0 20930000.0 28742000.0 27782000.0 False True 27439432.68640833 24453805.635438506 24907385.143761847 1.0 0.8911920998844591 0.9077223071051068 24.70974731813603 -9.92554028555696 6.2652906770064245 1.0000000186444071 0.8994572035017964 0.9801299071230699 0.006748428838878221 1.7510261870240669e-09 3.1081169407498583e-10 0.006534139294889367 0.002178046042164901 1.1870245864403478e-10 9.92554028555696 -0.10054281514261076 VCMYFTYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VCMYFTYK 8 0 E5RHG8;Q15369;Q15369-2 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 0 23381000.0 16274000.0 3941100.0 3165900.0 False True 15757390.777937237 5514801.782564995 2336655.815035831 1.0 0.3499819139020505 0.14828951366158333 23.909525326964314 -12.21936632828405 0.1937108187899145 2.7219825025815263 5.192578217996577e-24 0.9994195899176216 0.008755209887384777 5.88775443320663 0.12601949154637848 4.140842414226024 0.1326641225218408 6.034394122648549e-13 12.21936632828405 -2.7219825025815263 VCMYFTYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VCMYFTYK 8 0 E5RHG8;Q15369;Q15369-2 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 0 255661000.0 77935000.0 61596000.0 116130000.0 False True 118233092.8116916 50603712.548255384 93176854.5984128 1.0 0.4279995671673015 0.7880776217773008 26.817058653778563 -10.452963794298496 6.84723271372974 1.0000703978025656 0.6080385944723224 0.6123894119497433 0.14700125022808574 0.00015800638051901124 1.2623433907588322e-05 0.1423587365289786 0.047444449500420455 3.524002482667243e-11 10.452963794298496 -0.3920318033302431 VCMYFTYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCMYFTYK 8 0 E5RHG8;Q15369;Q15369-2 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 0 77030000.0 20930000.0 24537000.0 31563000.0 False True 28668386.611982547 23452874.206991684 24108469.46038974 1.0 0.8180744359429375 0.8409426657554948 24.772957379658923 -9.723920638525657 5.6033593948871845 1.0000000120606438 0.8295085508922506 0.986686249973894 0.009335915742147611 3119328.178343626 5413199.046239342 0.29817933032834465 0.0031959324409690133 1.8883363856421002e-10 9.723920638525657 -0.1704914611683932 VCMYFTYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VCMYFTYK 8 0 E5RHG8;Q15369;Q15369-2 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 0 31832600.0 16274000.0 3081600.0 12477000.0 False True 13532552.060440665 3064998.8091502953 15085883.012870088 1.0 0.226490819725728 1.1147847756647642 23.68993060239859 -6.676524965952011 1.9140950605230074 0.5090709512815851 1.1113277675482232 0.30830924028164775 0.328084191416345 0.44631500327092205 3.158338870087481 0.13768567145723484 0.36477996595394974 2.106080824866779e-07 6.676524965952011 0.6022568162666381 VCMYFTYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VCMYFTYK 8 0 E5RHG8;Q15369;Q15369-2 E5RHG8 TCEB1 Transcription elongation factor B polypeptide 1 0 300446000.0 77935000.0 132400000.0 90111000.0 False True 100888393.82852165 125031823.61104624 73711722.61693953 1.0 1.2393082976775385 0.7306263864426877 26.588184975871012 -6.778768495274024 1.5405894974567766 1.1357184699696397 0.7267456564951819 0.7630366307001907 0.10114955697689917 0.25249148036164315 1.1835728893339554 0.05171606134748375 0.1221584487783869 1.6642995843779588e-07 6.778768495274024 -0.4089728134744578 VCNALALLQCVASHPETR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCNALALLQCVASHPETR 18 0 Q92600;Q92600-3;Q92600-2 Q92600 RQCD1 Cell differentiation protein RCD1 homolog 0 5185270.0 894070.0 2723300.0 1567900.0 False True 1172134.428186197 2316994.2553402577 1405668.7483588026 1.0 1.9767308250860423 1.1992385127139256 20.160706606452983 -10.253103337974888 4.817132531392669 0.9998515891020601 1.5879846689009607 0.43264597881710953 0.3174099073780768 0.0005060400840787374 7.846155993384933e-05 0.30740753962412926 0.1024436070992324 5.583373256448197e-11 10.253103337974888 0.5881330797989006 VCNFLASQVPFPSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCNFLASQVPFPSR 14 0 Q99714;Q99714-2 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 72192000.0 17494000.0 25455000.0 29243000.0 False True 22934803.412136983 21657213.222812835 26217214.878663447 1.0 0.9442946963021251 1.143119232702445 24.451035205485756 -6.831906751244415 1.319242286735201 0.9702702861717836 1.1486853184029655 0.9096459251095803 0.025172545190052895 0.17847944544153357 0.6068064167978644 0.014977991768463622 0.03447023396850923 1.4726286612940168e-07 6.831906751244415 0.17841503223118194 VCNFLASQVPFPSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VCNFLASQVPFPSR 14 0 Q99714;Q99714-2 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 43371700.0 17931000.0 7997700.0 17443000.0 False True 17361790.219933156 11191223.317454537 12874155.021216713 1.0 0.6445892489016392 0.7415223233394349 24.049412379750752 -10.099063953556332 7.296918888254868 1.000000081846893 0.6930557861205379 0.9304079308581239 0.03957276192863654 5.269108414532615e-08 6.494428217087549e-09 0.038316172255384154 0.012772053992753355 7.960421178132343e-11 10.099063953556332 -0.3069442957263552 VCNFLASQVPFPSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VCNFLASQVPFPSR 14 0 Q99714;Q99714-2 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 63574200.0 9066200.0 54508000.0 0.0 False True 13754088.228002282 44780621.52705212 0.0 1.0 3.2558044404486344 0.0 23.71335716936632 -6.7203397327514445 1.7581695495506455 2.371899503810569 0.005000956902752985 0.5141094921656482 0.9492093775037878 0.35464585410765304 2.1426642921016787 0.42865367456622994 1.0756201128464382 1.9039707283195653e-07 6.7203397327514445 -2.366898546907816 VCNFLASQVPFPSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCNFLASQVPFPSR 14 0 Q99714;Q99714-2 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 63349000.0 17494000.0 20093000.0 25762000.0 False True 23962004.557573933 19205224.821334448 19677546.185044568 1.0 0.8014865690885633 0.8211978316657514 24.514245267008647 -10.792912492273752 7.020659457780799 1.006634128707899 0.8113422003772081 0.9918791849359643 0.008047089250021375 0.0008552025604568749 2.5225778576983e-05 0.007974270784156242 0.002597186887564789 1.610970203285468e-11 10.792912492273752 -0.19529192833069098 VCNFLASQVPFPSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VCNFLASQVPFPSR 14 0 Q99714;Q99714-2 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 32654800.0 17931000.0 5849800.0 8874000.0 False True 14910420.977987047 5818285.96630562 10729512.371259844 1.0 0.3902160760514695 0.7195982183937211 23.82981765518503 -10.622534935095674 6.713960255499962 1.0013006641706266 0.5549071472226484 0.708851106163191 0.134469696520549 0.002624590557311794 0.00014755677453999588 0.1305273170138507 0.043399907932804266 2.384871946191921e-11 10.622534935095674 -0.44639351694797813 VCNFLASQVPFPSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VCNFLASQVPFPSR 14 0 Q99714;Q99714-2 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 31309200.0 9066200.0 11621000.0 10622000.0 False True 11736374.62151976 10974281.13431999 8688904.990923764 1.0 0.9350656815433961 0.7403397787756221 23.484483491458768 -6.951460213672637 0.5425838853469881 1.0028191511891034 0.6635540797054085 0.9993108984691709 0.0028962875913673236 0.08290478784504482 0.03357739898894184 0.003174402357734307 0.016132837677076583 1.1182522645521205e-07 6.951460213672637 -0.3392650714836949 VCNPIITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCNPIITK 8 0 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 66405200.0 2251200.0 40037000.0 24117000.0 False True 2951345.000651811 34063635.6630037 21621604.186599445 1.0 11.541732889743718 7.326017182614797 21.49294114534213 -10.26825010284054 8.10203606290959 0.9999901291355101 9.43387503617255 0.8421823087301568 1.721058730517038 0.0003089977464980834 2.790233420098936e-05 1.6664098790361312 0.555469316761447 5.392000169251072e-11 10.26825010284054 8.43388490703704 VCNPIITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VCNPIITK 8 0 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 23250800.0 10485000.0 3375500.0 9390300.0 False True 10152159.414198834 4723354.7529999595 6930698.727038437 1.0 0.4652561647518915 0.6826822200353891 23.275283292587947 -10.238761011322273 5.5446404951181485 1.0000256238558407 0.5739691923936227 0.8365785207047663 0.08876381537185644 2.811790169477277e-05 3.860316836708508e-06 0.08595035433137763 0.0286483982234094 5.7708394057290824e-11 10.238761011322273 -0.42605643146221805 VCNPIITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCNPIITK 8 0 A8K7Q2;E9PS65;P11142;E9PKE3;E9PNE6 A8K7Q2;P11142 HSPA8 Heat shock cognate 71 kDa protein 0 45941200.0 2251200.0 22365000.0 21325000.0 False True 3083529.4763925024 21376840.348835196 16288474.202161139 1.0 6.9325882928949625 5.282412354694734 21.55615120686502 -9.611513196882939 7.300861849209266 0.9999953835512194 6.107500324330461 0.9273945071937223 0.6736815057436947 4.0450938619432085e-09 0.0 0.6522893130943386 0.21742977103144615 2.4461709432577254e-10 9.611513196882939 5.107504940779242 VCNYGLTFTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCNYGLTFTQK 11 0 E5RK27;E5RFP6;E5RJN6;E5RHZ6;Q9Y277;Q9Y277-2;E5RHE1 E5RK27 VDAC3 Voltage-dependent anion-selective channel protein 3 0 11657200.0 4263300.0 3891300.0 3502600.0 False True 5589227.585855931 3310733.208168599 3140184.5513116564 1.0 0.592341814197497 0.5618279991421695 22.414217490129303 -13.999999999999723 0.36776168489802086 6.599101892995059 0.5585528423678306 0.9997870444798034 0.002914987480609473 22.560355657715057 0.19664011283623203 99.48651104334613 0.008588182650093028 1.000000000000638e-14 13.999999999999723 -6.040549050627229 VCQFVVSVNGLNVLHVDYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VCQFVVSVNGLNVLHVDYR 19 0 Q8TB45;Q8TB45-2 Q8TB45 DEPTOR DEP domain-containing mTOR-interacting protein 0 96017000.0 29544000.0 22539000.0 43934000.0 False True 44820407.955714494 18516739.351989206 35250425.6430437 1.0 0.41313187890402425 0.7864815884289459 25.417652444541496 -10.085270339089444 5.3744795980485005 1.0000048537090604 0.5998067336661961 0.6050486283322114 0.15241938065974292 8.864648826905403e-06 1.5086663265986036e-06 0.14758122027088072 0.04919314357772286 8.217309806322062e-11 10.085270339089444 -0.40019812004286437 VCQFVVSVNGLNVLHVDYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VCQFVVSVNGLNVLHVDYR 19 0 Q8TB45;Q8TB45-2 Q8TB45 DEPTOR DEP domain-containing mTOR-interacting protein 0 63081000.0 29544000.0 10141000.0 23396000.0 False True 38245290.39930503 9576644.435344553 19138168.063232176 1.0 0.2504006201903117 0.5004058764730923 25.188778766633945 -10.247605088239423 5.506692452001674 1.0000449150967747 0.3754032483336956 0.8927295699395449 0.10206421848453222 5.6284601908597676e-05 7.69040154536071e-06 0.09883032738025702 0.032941084869506844 5.6545091576693764e-11 10.247605088239423 -0.6246416667630792 VCSNDTGSGK(ub)FK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCSNDTGSGKFK 12 1 Q9H9Y6;Q9H9Y6-3;Q9H9Y6-2;Q9H9Y6-4;Q9H9Y6-5;H7C0D9 Q9H9Y6 POLR1B DNA-directed RNA polymerase I subunit RPA2;DNA-directed RNA polymerase 1 1183450.0 228450.0 430300.0 524700.0 True False 299500.1623129471 366100.9172962631 470409.0772778003 1.0 1.2223730179943109 1.5706471530598733 18.192197259314046 -6.964530167679452 0.36603136646063394 0.9719829942787388 1.8330847803176429 0.9999031232147901 0.0023115091382856674 0.07812082030824896 0.015424675214810911 0.004620117204725578 0.02964319609995192 1.0851001719973334e-07 6.964530167679452 0.8611017860389041 VCSTNDLK(ub)ELLIFNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCSTNDLKELLIFNK 15 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 19374400.0 4862300.0 7554300.0 6957800.0 True False 6374522.386580178 6427227.886430759 6237873.599930393 1.0 1.008268148835988 0.9785632901788122 22.603885820891705 -6.832424990023797 1.3169265659065028 1.0044111921745609 0.9777229869209106 0.9106558302338423 0.003741649020454206 0.1778392690606556 0.6023210935944677 0.0022301417654383496 0.0051324481802943744 1.4708724379256328e-07 6.832424990023797 -0.026688205253650232 VCSTNDLK(ub)ELLIFNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VCSTNDLKELLIFNK 15 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 19712800.0 6704200.0 7657700.0 5350900.0 True False 6491378.840693543 10715459.544377947 3949338.7664408954 1.0 1.6507216428664178 0.608397516669809 22.630093524489542 -6.737913800132963 1.6945878766700229 1.3881092982425793 0.6080884017676164 0.5954682799594084 0.27342063526968874 0.32158526544171306 1.812470896400105 0.12769330805604326 0.3140376853201059 1.8284630981083203e-07 6.737913800132963 -0.780020896474963 VCSTNDLK(ub)ELLIFNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCSTNDLKELLIFNK 15 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 23654400.0 4862300.0 8178100.0 10614000.0 True False 6660023.7087168 7816764.50063979 8107191.802191704 1.0 1.1736841852993736 1.2172917329980093 22.667095882414596 -13.999999999999885 0.1940740658426164 0.055467800478757 1.2473254350221377 0.999487676654417 0.002124421335625998 12.41981364159674 0.13970216334449814 4.44256773221287 0.029045539460714538 1.0000000000002658e-14 13.999999999999885 1.1918576345433807 VCSTNDLK(ub)ELLIFNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VCSTNDLKELLIFNK 15 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 21092000.0 6704200.0 4607000.0 9780800.0 True False 5574839.34641798 4582181.176582094 11825920.05869038 1.0 0.8219395917707114 2.1213023952499954 22.41049879992382 -6.87228510373547 1.1219990826216073 0.8977705787989241 2.200757808518048 0.9669080008665938 0.10463007204020246 0.13467953391043075 0.31549796301048394 0.07226959232159075 0.1718053319966564 1.341883757965079e-07 6.87228510373547 1.3029872297191238 up VCSTNDLK(ub)ELLIFNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VCSTNDLKELLIFNK 15 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 36273000.0 10627000.0 7331000.0 18315000.0 True False 13756860.989487369 6923023.405533078 14981857.927769598 1.0 0.5032415033359333 1.08904625402687 23.713647980797507 -6.682029579470306 1.8948699123507502 0.6862613931101539 1.086840968606713 0.33331128128975107 0.21044665399142626 0.4340534881937939 3.0149507468646366 0.08906365572152594 0.234273756098233 2.0795550453511567e-07 6.682029579470306 0.4005795754965592 VCTLAIIDPGDSDIIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCTLAIIDPGDSDIIR 16 0 A0A0B4J213;P62888;E5RI99;A0A0C4DH44 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 0 76759000.0 14768000.0 37932000.0 24059000.0 False True 19360991.01351543 32272693.457777917 21569605.470224112 1.0 1.6668926417686545 1.1140754858657236 24.206649464638733 -10.139605203994133 4.074119809555993 0.9998834887914587 1.3904840637607645 0.3994881598783142 0.22568665916440486 25279405.49378152 12583018.208595756 25883.766664982762 0.07725854499250703 7.250948090155766e-11 10.139605203994133 0.3906005749693058 VCTLAIIDPGDSDIIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VCTLAIIDPGDSDIIR 16 0 A0A0B4J213;P62888;E5RI99;A0A0C4DH44 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 0 45888800.0 25727000.0 8215800.0 11946000.0 False True 24910310.46724781 11496411.784830997 8816984.22768188 1.0 0.46151218387850007 0.35394919060822194 24.570239666792595 -13.999999999999998 0.22643580719075806 4.344199319636171 0.2998454513553876 0.9995051388929462 0.006287249277141368 13.182773023565993 0.15069604684676197 19.781579957914776 0.05709960373201095 1.0000000000000041e-14 13.999999999999998 -4.044353868280783 VCTLAIIDPGDSDIIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VCTLAIIDPGDSDIIR 16 0 A0A0B4J213;P62888;E5RI99;A0A0C4DH44 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 0 132428000.0 12727000.0 99511000.0 20190000.0 False True 19307789.46833125 81752484.5670082 16199437.650408644 1.0 4.234171120474413 0.8390104769362157 24.20267966508067 -6.657112298902881 1.9827391519188808 3.0866129462473406 0.8530503961268189 0.22367552130638435 1.3779675134185558 0.49124177701919863 3.709199954963432 0.5620366011360921 1.5274920675465427 2.2023569088599278e-07 6.657112298902881 -2.2335625501205216 VCTLAIIDPGDSDIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCTLAIIDPGDSDIIR 16 0 A0A0B4J213;P62888;E5RI99;A0A0C4DH44 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 0 67365000.0 14768000.0 26882000.0 25715000.0 False True 20228128.690193884 25694264.353113644 19641646.617049184 1.0 1.2702244852520448 0.9710066075746783 24.269859526161625 -6.668790909758619 1.9413536023475488 1.1726568958007186 0.9722133701339069 0.27386513922144773 0.11481652923068948 0.46387852984924555 3.3692804306217456 0.047629369779066406 0.12746891086371903 2.1439225400629658e-07 6.668790909758619 -0.20044352566681178 VCTLAIIDPGDSDIIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VCTLAIIDPGDSDIIR 16 0 A0A0B4J213;P62888;E5RI99;A0A0C4DH44 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 0 41193900.0 25727000.0 3925900.0 11541000.0 False True 21393140.39934599 3904750.397469859 13954169.740445105 1.0 0.1825234783009806 0.6522730875393917 24.35064494222687 -10.654336035024055 5.441390349117457 1.0076644179465306 0.4173982829705582 0.6722303616332492 0.1917744749176499 0.017900255040772018 0.0011371113281612231 0.1864034851828806 0.0618949456319774 2.2164807558450634e-11 10.654336035024055 -0.5902661349759724 VCTLAIIDPGDSDIIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VCTLAIIDPGDSDIIR 16 0 A0A0B4J213;P62888;E5RI99;A0A0C4DH44 A0A0B4J213;P62888 RPL30 60S ribosomal protein L30 0 55369000.0 12727000.0 24817000.0 17825000.0 False True 16475352.386675982 23435912.134103708 14581032.89994504 1.0 1.4224832091031268 0.8850210033587552 23.97380598717312 -6.697037975139607 1.8410507370236369 1.2630921001933006 0.8866833597626477 0.4037534982795761 0.17843232899572362 0.4016900687411022 2.644768883475085 0.0773749094343736 0.19974693477958072 2.008917143223925e-07 6.697037975139607 -0.376408740430653 VCVEHHTFFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCVEHHTFFR 10 0 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6;J3KT37;A8K968;A0A0A0MRA8;Q9Y2J2-2;Q9Y2J2;A0A0A0MSA4;Q9Y2J2-4;A0A1B0GTF8;Q9Y2J2-3 P11171;A8K968 EPB41;EPB41L3 Protein 4.1;Band 4.1-like protein 3;Band 4.1-like protein 3, N-terminally processed 0 9658500.0 3109800.0 2915200.0 3633500.0 False True 4076977.915346034 2480263.5233605974 3257540.274993119 1.0 0.6083583416100219 0.7990085653227373 21.95906871121145 -10.128270414028023 5.064827920635899 1.0000101103136287 0.7036834534693778 0.763083145243251 0.07783262791279669 1.0012415528740793e-05 1.7232210343876441e-06 0.07536401389857947 0.02512037264066705 7.442684099012841e-11 10.128270414028023 -0.29632665684425097 VCVEHHTFFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VCVEHHTFFR 10 0 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6;J3KT37;A8K968;A0A0A0MRA8;Q9Y2J2-2;Q9Y2J2;A0A0A0MSA4;Q9Y2J2-4;A0A1B0GTF8;Q9Y2J2-3 P11171;A8K968 EPB41;EPB41L3 Protein 4.1;Band 4.1-like protein 3;Band 4.1-like protein 3, N-terminally processed 0 8153400.0 1793000.0 3741600.0 2618800.0 False True 2720112.0858582496 3073882.246745767 2101193.032139184 1.0 1.1300571997480375 0.7724656064958498 21.375234670204257 -6.808278082558436 1.421600539871123 1.0710259689726758 0.7664434961748402 0.8553258072614058 0.05621085836588186 0.20915601852887877 0.8333859655358071 0.031092766986177984 0.07198698714145843 1.554969652091967e-07 6.808278082558436 -0.30458247279783557 VCVEHHTFFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCVEHHTFFR 10 0 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6;J3KT37;A8K968;A0A0A0MRA8;Q9Y2J2-2;Q9Y2J2;A0A0A0MSA4;Q9Y2J2-4;A0A1B0GTF8;Q9Y2J2-3 P11171;A8K968 EPB41;EPB41L3 Protein 4.1;Band 4.1-like protein 3;Band 4.1-like protein 3, N-terminally processed 0 6428100.0 3109800.0 1604900.0 1713400.0 False True 4259577.099185054 1533990.2113054153 1308730.2085806746 1.0 0.3601273496373383 0.3072441648799037 22.022278772734342 -13.999999999999998 0.3532491767886662 9.028552514795662 0.3002490760497565 0.9997608506218201 0.004868897337588492 20.987640521956248 0.19156276031106048 126.63371714048279 0.01560558383599419 1.0000000000000041e-14 13.999999999999998 -8.728303438745906 VCVEHHTFFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VCVEHHTFFR 10 0 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6;J3KT37;A8K968;A0A0A0MRA8;Q9Y2J2-2;Q9Y2J2;A0A0A0MSA4;Q9Y2J2-4;A0A1B0GTF8;Q9Y2J2-3 P11171;A8K968 EPB41;EPB41L3 Protein 4.1;Band 4.1-like protein 3;Band 4.1-like protein 3, N-terminally processed 0 8725600.0 1793000.0 3320700.0 3611900.0 False True 2321073.8453139025 3135900.125870099 2954571.261223644 1.0 1.3510557331905997 1.2729329000836107 21.146360992296707 -10.135098162502686 4.562025751990304 0.9999646457695842 1.3119943166439008 0.9550875185252905 0.031893513085282384 1.146973534707869e-05 2.1745861678392223e-06 0.030884256304440024 0.010293587082684422 7.32658913348492e-11 10.135098162502686 0.31202967087431654 VCVEK(ub)WNLLNSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCVEKWNLLNSSR 13 1 O00418 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 86564000.0 34980000.0 51584000.0 0.0 True False 47913051.29895599 49304848.31452324 0.0 1.0 1.0290483903202712 0.0 25.513915357324866 -7.002593617554022 1.1179024989054973 1.031539236973676 3.4934280890197165e-20 0.9835291019408369 0.06139715751487008 0.0914627383667154 0.2235208748072953 0.04625545379145546 0.08471389160747052 9.940457719793192e-08 7.002593617554022 -1.031539236973676 down VCVEK(ub)WNLLNSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VCVEKWNLLNSSR 13 1 O00418 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 78338100.0 47611000.0 25101000.0 5626100.0 True False 39590656.02492563 24965775.93084162 6802491.497852724 1.0 0.6305976823198781 0.17182063094812036 25.238656637517042 -7.496716297248542 0.42744988916211757 1.02958896216903 6.2474754467628086e-24 0.9985621058964606 0.012845574466079736 0.117763322456007 0.05320055424857117 0.01934032433599113 0.06671240797662344 3.186278277438385e-08 7.496716297248542 -1.02958896216903 down VCVETVESGAMTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCVETVESGAMTK 13 0 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 10075700.0 1191700.0 3455400.0 5428600.0 False True 1562330.2404392166 2939867.789043704 4866900.54680821 1.0 1.8817198265439843 3.1151547994359903 20.57526800736656 -6.9663909300488 0.33331871764261894 0.855426160382864 4.182027859800902 0.9999390125190414 0.006774526427078033 0.07749208067438618 0.013212710357227955 0.017791128458907856 0.10730002238322747 1.0804609368431472e-07 6.9663909300488 3.3266016994180383 VCVETVESGAMTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCVETVESGAMTK 13 0 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 10332900.0 1191700.0 4783500.0 4357700.0 False True 1632303.6944815863 4572149.153080844 3328501.009648653 1.0 2.8010407429316895 2.0391432188149112 20.63847806888945 -10.594068343222958 6.107719796873808 0.9952902304373775 2.4200919808733 0.8224465480338272 0.31104336172932456 0.01992646059959748 0.001324352653277339 0.30083976552111524 0.10038881332717023 2.5464294994088e-11 10.594068343222958 1.4248017504359227 VCVSVVSEK(ub)CR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VCVSVVSEKCR 11 1 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;Q9Y2X0-4;Q9Y2X0-5;U3KQ43;B9TWZ6 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 5618100.0 1644900.0 1887100.0 2086100.0 True False 2156479.8292342615 1605552.0358581871 1870250.3832842023 1.0 0.7445244857348368 0.8672700564736117 21.040246791123554 -10.083418472769544 4.640050358733125 1.000010840445666 0.8058972710992379 0.7692763851949989 0.05011066943316952 69648181.0531253 0.18454883110835008 8066.705434553472 0.017154215010089627 8.252423882339119e-11 10.083418472769544 -0.1941135693464281 VCVSVVSEK(ub)CR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VCVSVVSEKCR 11 1 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;Q9Y2X0-4;Q9Y2X0-5;U3KQ43;B9TWZ6 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 21982000.0 3080200.0 5075800.0 13826000.0 True False 4672888.592783377 4169983.8325935886 11093285.039848937 1.0 0.8923781831720846 2.373967369344299 22.155883211372835 -6.889434009400787 1.0257496372239965 0.9193086454740184 2.4999820965041026 0.9805326613558385 0.09410900123449316 0.11960257623803139 0.22455182842795166 0.06995881256822904 0.17405286741186735 1.2899295464742337e-07 6.889434009400787 1.5806734510300844 up VCVSVVSEK(ub)CR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VCVSVVSEKCR 11 1 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;Q9Y2X0-4;Q9Y2X0-5;U3KQ43;B9TWZ6 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 8053600.0 1644900.0 1278400.0 5130300.0 True False 2253063.981751081 1221916.06089653 3918628.801845123 1.0 0.5423352691239851 1.7392443506196238 21.103456852646445 -6.803080646013907 1.4434011913714098 0.7484602925787159 1.757030089196351 0.8409763474514033 0.19664636164571903 0.21639968794889788 0.8897523223453679 0.10716415342063496 0.2487603720301686 1.573690611940801e-07 6.803080646013907 1.008569796617635 VCVSVVSEK(ub)CR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VCVSVVSEKCR 11 1 Q9Y2X0;Q9Y2X0-3;Q9Y2X0-2;Q9Y2X0-4;Q9Y2X0-5;U3KQ43;B9TWZ6 Q9Y2X0 MED16 Mediator of RNA polymerase II transcription subunit 16 1 18401500.0 3080200.0 3381300.0 11940000.0 True False 3987379.619819239 3193127.6825984186 9767042.514745785 1.0 0.8008085477306958 2.4494889992913587 21.927009533465284 -6.876708287440929 1.0980341340769797 0.8811924023454729 2.559179668708017 0.9709299785541007 0.12527599079903162 0.1305838393078802 0.2902694517218517 0.08813405362136545 0.21145144294316418 1.3282863587902157e-07 6.876708287440929 1.677987266362544 up VDAAWEPSK(ub)NTLIMGLGTQGAEK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VDAAWEPSKNTLIMGLGTQGAEK 23 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 139102500.0 24616800.0 45934700.0 68551000.0 True False 32272863.18943032 39081421.812058195 61458000.10762437 1.0 1.2109685336148839 1.9043243776323033 24.943818240981305 -6.949383901975174 0.5655673009803542 0.991182396792605 2.157565318473257 0.9991520413443193 0.011248964405178934 0.08373409276985827 0.03699356827153999 0.011978742986464954 0.057708949476592705 1.1236112995734069e-07 6.949383901975174 1.166382921680652 VDAAWEPSK(ub)NTLIMGLGTQGAEK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VDAAWEPSKNTLIMGLGTQGAEK 23 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 320749000.0 70365000.0 94200000.0 156184000.0 True False 68131301.59085372 131814551.24651039 115274724.98043405 1.0 1.934713533554536 1.6919495487212164 26.021814432708492 -9.992270357635364 5.2529706908538145 0.999995867281833 1.8133315411411282 0.9373668652355234 0.09910798180577043 4.801886339497871e-06 9.211793313547754e-07 0.09596137953669459 0.03198696358252558 1.0179574903830204e-10 9.992270357635364 0.8133356738592952 VDAAWEPSK(ub)NTLIMGLGTQGAEK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VDAAWEPSKNTLIMGLGTQGAEK 23 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 359814000.0 87089000.0 184999000.0 87726000.0 True False 132120380.05873372 151984483.04621583 70386917.64832836 1.0 1.1503485153361774 0.5327483739983042 26.97727778391113 -6.84236880744701 1.2713739768039605 1.0799723829207983 0.5114667939109576 0.9284483879618839 0.07034104811258372 0.16604886760555035 0.5203464977726024 0.04336594689699681 0.09997783323798519 1.4375772540072186e-07 6.84236880744701 -0.5685055890098407 VDAAWEPSK(ub)NTLIMGLGTQGAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VDAAWEPSKNTLIMGLGTQGAEK 23 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 198061400.0 24616800.0 64936600.0 108508000.0 True False 33718296.20400631 62067486.29537986 82880645.19240786 1.0 1.8407657943287534 2.458031826132432 25.007028302504196 -7.468569627710509 0.13540201570392169 2.537257828588511e-18 4.009271690451439 0.999991608976778 0.001730974213204789 0.13184098917225745 0.011498165656049835 0.12084583847976134 0.19991380576124473 3.39961997459792e-08 7.468569627710509 4.009271690451439 VDAAWEPSK(ub)NTLIMGLGTQGAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VDAAWEPSKNTLIMGLGTQGAEK 23 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 313270000.0 70365000.0 120230000.0 122675000.0 True False 58511615.19804027 119582297.12621361 148325775.31488657 1.0 2.043736046620343 2.534980017435144 25.80221970814277 -9.58495325349084 0.20712609480894537 5.480442586247095e-16 2.9734238988502733 0.9994146849224711 0.015484687232106102 1.0169160269372302 0.08484671875664092 0.9001588844209323 0.27382812722833555 2.6004394537228066e-10 9.58495325349084 2.973423898850273 VDAAWEPSK(ub)NTLIMGLGTQGAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VDAAWEPSKNTLIMGLGTQGAEK 23 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 303953600.0 87089000.0 163571000.0 53293600.0 True False 112738427.28083819 154468130.05953518 43594711.63851389 1.0 1.3701462206382016 0.3866890171344758 26.74840410600358 -6.804722634539892 1.436360813929858 1.2030176584507304 0.3714446639805634 0.845674007413773 0.15932355863794864 0.21407671990035115 0.8713723719855195 0.08723910449749989 0.20234885887680507 1.5677520071392512e-07 6.804722634539892 -0.831572994470167 down VDACLELLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDACLELLIR 10 0 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 0 11934000.0 2777100.0 5096600.0 4060300.0 False True 4213063.733205219 4187071.9100824483 3257779.9253072906 1.0 0.9938306598787205 0.7732567394200879 22.006438309787274 -6.912887149595812 0.8758325112421299 1.0062217161699165 0.7429171006390742 0.991966479974714 0.009452704154689791 0.10253992411651762 0.12863646959689215 0.00785126898946447 0.022132445955969467 1.2221171831976483e-07 6.912887149595812 -0.2633046155308423 VDATADYICK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDATADYICK 10 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 16585800.0 2138700.0 8109000.0 6338100.0 False True 2803856.411200265 6899168.808634426 5682294.211348248 1.0 2.460599901291327 2.0265995750173924 21.41898103844677 -10.568263128596797 5.480032362800169 0.9946451341627431 2.243599738154361 0.9163013490742835 0.17717989126209696 0.011588409594753726 0.0009129757700349256 0.17150468787336123 0.05718456401174457 2.7023205968648937e-11 10.568263128596797 1.2489546039916177 VDATADYICK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDATADYICK 10 0 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 0 12681900.0 2138700.0 4437200.0 6106000.0 False True 2929435.18619432 4241149.832141807 4663888.557017387 1.0 1.447770495872127 1.5920777421521741 21.48219109996966 -11.787297961496835 0.19434858695422247 4.62379057502275e-09 1.7041482548437394 0.9994139249728378 0.006102492483095203 4.747152502404667 0.12015326318653134 2.0419264308139033 0.09496261083022377 1.6319319250937761e-12 11.787297961496835 1.7041482502199488 VDATADYICK(ub)VK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDATADYICKVK 12 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 1 5382830.0 1075000.0 822630.0 3485200.0 True False 1409335.4103148072 699896.8105866254 3124584.936399069 1.0 0.49661479124425567 2.2170626761596246 20.42658357146978 -6.828404328558366 1.335241326894776 0.7307246871408686 2.26179643238198 0.9026029044976525 0.22539801182783556 0.1827909275254035 0.6379552206759942 0.132569294369277 0.3050712761705112 1.4845528786270949e-07 6.828404328558366 1.5310717452411113 up VDATADYICK(ub)VK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDATADYICKVK 12 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 1 19532600.0 2994600.0 0.0 16538000.0 True False 4543027.134585117 0.0 13269257.051137092 1.0 0.0 2.920796345265255 22.11522249167117 -6.814291133861288 1.3964033414093768 0.4577092410755169 2.9770749758539594 0.8707437191392047 0.43574125085473836 0.2010047168054999 0.7716341678618321 0.2453052313949067 0.5664243778845062 1.5335885809466697e-07 6.814291133861288 2.5193657347784426 VDATADYICK(ub)VK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDATADYICKVK 12 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 1 5642410.0 1075000.0 994710.0 3572700.0 True False 1472456.550782666 950760.423133907 2728901.8420661725 1.0 0.6456967593566969 1.8532987208455547 20.489793632992672 -6.828159878244264 1.3361844657765978 0.8104325397487329 1.8845740579987114 0.9021325537327626 0.1585576785881821 0.18309127574563924 0.6399669403095288 0.09318990932791608 0.21447046720129526 1.485388720628187e-07 6.828159878244264 1.0741415182499785 VDATADYICK(ub)VK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDATADYICKVK 12 1 P53396;P53396-2 P53396 ACLY ATP-citrate synthase 1 28402000.0 2994600.0 2855400.0 22552000.0 True False 3876568.732390973 2696494.479901672 18447767.403060876 1.0 0.6955879454350704 4.758787648705701 21.886348813763618 -6.888844553445597 1.029164132670155 0.7755946564363292 5.100488577300767 0.9801494556338909 0.26034634609547264 0.12008682777636889 0.22734910355769936 0.19303019280406689 0.4792819422526331 1.2916815210531638e-07 6.888844553445597 4.3248939208644375 up VDATEESDLAQQYGVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDATEESDLAQQYGVR 16 0 P07237;H7BZ94;I3NI03;I3L3U6 P07237 P4HB Protein disulfide-isomerase 0 49563500.0 3815500.0 24901000.0 20847000.0 False True 5002157.449354555 21185867.863337755 18689952.41854453 1.0 4.235346063741243 3.7363782743296405 22.254119038244102 -9.509438075408871 11.767864729062955 1.000000000000572 3.985862169035442 0.9794853219732716 0.2037027470238196 0.0 0.0 0.197234336699989 0.06574477889999632 3.0942964893390396e-10 9.509438075408871 2.98586216903487 VDATEESDLAQQYGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDATEESDLAQQYGVR 16 0 P07237;H7BZ94;I3NI03;I3L3U6 P07237 P4HB Protein disulfide-isomerase 0 44600100.0 13756000.0 5426100.0 25418000.0 False True 13319323.309653709 7592770.026737697 18760263.27634503 1.0 0.5700567401374315 1.4084997293179138 23.667017452130782 -6.767302116394527 1.5848184739855815 0.752560575889731 1.4127433316739304 0.720205035049136 0.1810777960976742 0.2707697827011306 1.3417422815306186 0.09008515960744465 0.21497192867618267 1.7088261588139119e-07 6.767302116394527 0.6601827557841994 VDATEESDLAQQYGVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDATEESDLAQQYGVR 16 0 P07237;H7BZ94;I3NI03;I3L3U6 P07237 P4HB Protein disulfide-isomerase 0 60773500.0 3815500.0 26727000.0 30231000.0 False True 5226193.4600104755 25546112.765630104 23091060.426988665 1.0 4.88809167917387 4.418332502169252 22.317329099766994 -10.17130337798416 5.114601810215608 0.9997890295431939 4.6532120906749235 0.9877507525920182 0.19177838095354896 0.0004613775647674396 7.475641406372835e-05 0.18569816793367952 0.0618962062979628 6.74056998238595e-11 10.17130337798416 3.6534230611317295 VDCPVCGVNIPESHINK(ub)HLDSCLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDCPVCGVNIPESHINKHLDSCLSR 25 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 193384700.0 50706000.0 76685000.0 65993700.0 True False 66476057.03760255 65243896.91578881 59165304.98027057 1.0 0.9814646027950068 0.8900242826797532 25.986331476810204 -6.940108421129256 0.6585841138195153 1.0010245450546296 0.8652893770153247 0.9981776645573555 0.002052192876533821 0.08771790604740906 0.054391019933052655 0.0019992574088604467 0.00786637137834493 1.1478670220119191e-07 6.940108421129256 -0.13573516803930485 VDCPVCGVNIPESHINK(ub)HLDSCLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDCPVCGVNIPESHINKHLDSCLSR 25 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 58128300.0 26990500.0 21592000.0 9545800.0 True False 26133701.351352718 30213798.20079249 7045468.612138424 1.0 1.1561239563652006 0.26959321672104974 24.639408134184173 -6.861431431934826 1.1785684993458927 1.085040925981323 0.22549211058499105 0.9553519879682087 0.0816484635110145 0.14532924183885185 0.3827863706858803 0.05400352977788412 0.12626300070827323 1.375842016300433e-07 6.861431431934826 -0.8595488153963319 down VDCPVCGVNIPESHINK(ub)HLDSCLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDCPVCGVNIPESHINKHLDSCLSR 25 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 418455000.0 184016000.0 142906000.0 91533000.0 True False 279165725.3716072 117403307.77032569 73441462.42966087 1.0 0.4205505801761519 0.26307478230681935 28.05654658434356 -13.999999999999966 0.18282831786617257 4.033148966501576 0.14156944930445942 0.9994949990099908 0.007120613321514174 12.242651602335478 0.13556937369847558 13.200378926806389 0.11481087093874665 1.0000000000000778e-14 13.999999999999966 -3.891579517197117 VDCPVCGVNIPESHINK(ub)HLDSCLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDCPVCGVNIPESHINKHLDSCLSR 25 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 181178300.0 50706000.0 72342200.0 58130100.0 True False 69453378.4781265 69145882.4003356 44400967.60698927 1.0 0.9955726260618446 0.6392916886105522 26.049541538333095 -6.909611717219905 0.8983763972789242 1.0111670764304297 0.5936289454357928 0.990774183910746 0.01623317977610877 0.10467528779478034 0.14016466246363227 0.013264859739621777 0.03651918571248077 1.2313691895455178e-07 6.909611717219905 -0.4175381309946369 VDCPVCGVNIPESHINK(ub)HLDSCLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDCPVCGVNIPESHINKHLDSCLSR 25 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 61900500.0 26990500.0 5977600.0 28932400.0 True False 22443796.63188663 5945397.482339291 34982031.07169694 1.0 0.264901593070598 1.5586503320029566 24.41981340961845 -6.752585349572921 1.6404419592750894 0.5691018549342797 1.5617140260850664 0.65997320783792 0.3089392619304756 0.2955469985181587 1.565601527597004 0.14872736618701368 0.36007177271694546 1.7677247820939036e-07 6.752585349572921 0.9926121711507867 VDCPVCGVNIPESHINK(ub)HLDSCLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDCPVCGVNIPESHINKHLDSCLSR 25 1 Q9NS91;F8WE49 Q9NS91 RAD18 E3 ubiquitin-protein ligase RAD18 1 326378000.0 184016000.0 94506000.0 47856000.0 True False 238212339.49764815 89246658.02254942 39146699.04402637 1.0 0.37465170028872724 0.16433531162399276 27.82767290643601 -11.745058471329905 0.19152426501036363 2.38828997140821 4.1063369409898636e-15 0.9994175590772608 0.008565250156943784 4.68043933714259 0.11895450143437868 2.7756360207724824 0.13981959334693664 1.7986287400636884e-12 11.745058471329905 -2.388289971408206 VDCQAYAQTCQK(ub)AGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDCQAYAQTCQKAGIR 16 1 Q8IXB1;Q8IXB1-2 Q8IXB1 DNAJC10 DnaJ homolog subfamily C member 10 1 7163200.0 1464000.0 2765500.0 2933700.0 True False 1919318.1773961652 2352898.1798345675 2630148.8660375117 1.0 1.2259031397423727 1.3703558362614436 20.872162465277 -9.900495632082185 0.06046967338569642 1.8199820042817624e-07 2.165623364699673 0.9999896696924596 0.0004898273389467968 1.506761320765445 0.027900977188109063 0.6146535126789856 0.39132521652822644 1.2574895015077996e-10 9.900495632082185 2.1656231827014727 VDCQAYAQTCQK(ub)AGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDCQAYAQTCQKAGIR 16 1 Q8IXB1;Q8IXB1-2 Q8IXB1 DNAJC10 DnaJ homolog subfamily C member 10 1 20672600.0 3607800.0 6125800.0 10939000.0 True False 4670368.220370057 5784893.844989024 8948214.243618445 1.0 1.2386376345569294 1.9159547644638248 22.155104868458196 -6.952689796413226 0.528493331371013 0.9892008168752499 2.1960597738810295 0.9993957948913353 0.009536502982739663 0.08242336657116237 0.03162942150264227 0.010663190712272478 0.05599976117811746 1.1150907252347317e-07 6.952689796413226 1.2068589570057795 VDCTAHSDVCSAQGVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDCTAHSDVCSAQGVR 16 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 76634000.0 3044500.0 40732300.0 32857200.0 False True 3991368.9829799356 34655199.61326188 29457452.132517934 1.0 8.682534679464409 7.380287880707323 21.928452224597535 -10.563761186795587 16.264072015544002 0.9999994357922217 8.031411280085866 0.9749197576028669 0.5316400293546184 1.0888809071060988e-05 2.924057647454936e-07 0.5147583061003875 0.1715860816556383 2.730478826856245e-11 10.563761186795587 7.031411844293644 VDCTAHSDVCSAQGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDCTAHSDVCSAQGVR 16 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 20382860.0 16231960.0 1595700.0 2555200.0 False True 15716685.314725691 2232871.3314655693 1885916.4656431219 1.0 0.1420701176331048 0.11999454260728369 23.905793646168885 VDCTAHSDVCSAQGVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDCTAHSDVCSAQGVR 16 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 85278300.0 3044500.0 39464900.0 42768900.0 False True 4170133.9245189084 37721210.22502778 32667766.673144642 1.0 9.045563261947162 7.833745214049305 21.991662286120427 -9.907765971451207 13.77880680623848 1.0000522488636079 8.439654237998237 0.9804892735195967 0.4947226473272442 0.0 0.0 0.47901315738191486 0.15967104770231869 1.2366136287190186e-10 9.907765971451207 7.439601989134629 VDCTAHSDVCSAQGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDCTAHSDVCSAQGVR 16 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 8455070.0 907270.0 3636100.0 3911700.0 False True 1174478.899965392 3433747.83861122 3199810.7374314144 1.0 2.923635187241253 2.72445144610576 20.1635893642505 -9.684765811472326 6.2470971998691835 0.9999999889421629 2.8240433166797287 0.9911359545955871 0.08131642182899797 1.2477630250636899e-08 2.6292615177410705e-09 0.07873428686941271 0.0262447622898049 2.0664941897050208e-10 9.684765811472326 1.8240433277375658 VDCTANTNTCNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDCTANTNTCNK 12 0 H7BZJ3;P30101 H7BZJ3;P30101 PDIA3 Protein disulfide-isomerase A3 0 10303000.0 7015100.0 2019600.0 1268300.0 False True 6792409.490371595 2826036.812074865 936094.1818155807 1.0 0.4160580742490335 0.13781474499476465 22.695492005824125 -9.071200793412325 0.2810427251351086 1.2861981985645756 1.9522496432017144e-21 0.998820556804994 0.012338929027917979 0.5202800514837873 0.09919981129278246 0.25050224639293917 0.10035880806524668 8.487879523556327e-10 9.071200793412325 -1.2861981985645756 VDCTQHYELCSGNQVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDCTQHYELCSGNQVR 16 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 125043100.0 15224000.0 54250300.0 55568800.0 False True 19958811.429425742 46156366.706013136 49819073.62956859 1.0 2.31258093044377 2.496094209103011 24.250522473266983 -10.549755210149184 0.3976408164856537 1.1324619573733795e-22 2.5130433129171794 0.9993082050777561 0.01752335676375853 2.040138393296571 0.18906873798843266 2.0955490672189585 0.04706401895335165 2.8199719590709553e-11 10.549755210149184 2.5130433129171794 VDCTQHYELCSGNQVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDCTQHYELCSGNQVR 16 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 25450700.0 19888000.0 2140200.0 3422500.0 False True 19256666.32614082 2994793.020995561 2526044.577200838 1.0 0.15551980650618355 0.1311776677446888 24.198854632656477 VDCTQHYELCSGNQVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDCTQHYELCSGNQVR 16 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 234883100.0 2620000.0 229459700.0 2803400.0 False True 3974731.54765679 188510823.75818118 2249306.761226133 1.0 47.42730961775603 0.5659015544212437 21.922425993760697 -6.240688334711756 23.011336275855058 9.999999999999998 0.5658727104875794 0.0 22.224637269056277 1860.4139416987662 4596995.896239 9.513266225672842 76.4993817252091 5.745286166315031e-07 6.240688334711756 -9.43412728951242 VDCTQHYELCSGNQVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDCTQHYELCSGNQVR 16 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 111024400.0 15224000.0 45029900.0 50770500.0 False True 20852724.213130563 43040330.124033645 38779553.551269494 1.0 2.0640147389918466 1.8596876434423253 24.313732534789875 -10.586779596880923 7.091878150690991 0.9988712490744689 1.9618511912170522 0.9672627731404237 0.08341618745353849 0.0014899578864482955 8.681476753627301e-05 0.08083460775794138 0.026922458734305883 2.589526758635947e-11 10.586779596880923 0.9629799421425833 VDCTQHYELCSGNQVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDCTQHYELCSGNQVR 16 0 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 0 18007200.0 2620000.0 9649600.0 5737600.0 False True 3391641.6479210453 9112591.277319873 4693415.67274752 1.0 2.6867789180810315 1.3838182685439115 21.693552315853147 -6.580937001018349 2.2635062311363416 2.147962547463125 1.3870907542944888 0.0 0.732602625026206 0.6962916547397942 6.711509205765464 0.27163398277481327 0.8185971034398778 2.624599241491965e-07 6.580937001018349 -0.7608717931686364 VDDFLANEAK(ub)GTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDDFLANEAKGTK 13 1 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 16475000.0 3858200.0 5988200.0 6628600.0 True False 5058137.56286195 5094783.901820782 5942736.058021022 1.0 1.0072450261590151 1.1748862074558835 22.27017484289314 -6.915967169232415 0.8541174814019669 0.9957366703437568 1.1995607505025294 0.9929849645261777 0.0067665155640601 0.1006031061772174 0.1183454239066252 0.005708784243606332 0.016493030055231978 1.2134805808340475e-07 6.915967169232415 0.20382408015877262 VDDFLANEAK(ub)GTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDDFLANEAKGTK 13 1 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 17678600.0 4626100.0 4464500.0 8588000.0 True False 4479246.987699118 6247198.132059927 6338545.165522519 1.0 1.3946982939802037 1.415091684591047 22.094824788566335 -11.817682131753745 0.4674822397942319 3.4630743525145057e-20 1.4147593442124242 0.99984531709644 0.0023761222476360875 5.303236358542643 0.23224892496614427 5.2825596999689814 0.004428816605784629 1.5216608542633007e-12 11.817682131753745 1.4147593442124242 VDDFLANEAK(ub)GTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDDFLANEAKGTK 13 1 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 60941100.0 10359000.0 19112600.0 31469500.0 True False 15715360.34434223 15701807.202574633 25249539.531428136 1.0 0.9991375863186951 1.6066790056467497 23.905672016910426 -6.906577184553475 0.918736116198518 0.9790927680115804 1.6797040208429057 0.9895642241299831 0.029236405268628023 0.1067252617330525 0.15137036496453374 0.023538256751016083 0.06353333844566897 1.2400032271981376e-07 6.906577184553475 0.7006112528313253 VDDFLANEAK(ub)GTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDDFLANEAKGTK 13 1 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 14815000.0 3858200.0 3750500.0 7206300.0 True False 5284680.803934595 3584790.5087550287 5504320.3584072115 1.0 0.6783362404946105 1.0415615554886661 22.333384904416032 -6.672993548921517 1.926625251417986 0.7952131325571467 1.0401176513910944 0.2923866547983156 0.13654247629767113 0.454309273531566 3.25386551740571 0.056995832879991964 0.1516941835707308 2.1232760012413665e-07 6.672993548921517 0.2449045188339477 VDDFLANEAK(ub)GTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDDFLANEAKGTK 13 1 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 16671700.0 4626100.0 6468600.0 5577000.0 True False 3846807.120978528 6433752.36788343 6743124.914865474 1.0 1.6724915405290322 1.7529147427464982 21.87523006400061 -11.319672460228034 0.36831732277787393 1.524049709898515e-13 1.7630642149973597 0.9995236273350222 0.007367830591346368 3.487147251648072 0.1859717042291311 2.8501656658506116 0.02255573510167964 4.789912056452439e-12 11.319672460228034 1.7630642149972073 VDDFLANEAK(ub)GTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDDFLANEAKGTK 13 1 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 59375400.0 10359000.0 22768500.0 26247900.0 True False 13409929.706417585 21501412.959879927 21471051.526197307 1.0 1.6033949044184777 1.6011308035359733 23.676798339002875 -10.086687933425674 4.728956983558733 0.9999711083333339 1.602262853986936 0.9999894003133304 0.00092431534805308 2.8156604010161815e-07 5.437906278200661e-08 0.0008950073121447649 0.00029832149107964233 8.190531154125512e-11 10.086687933425674 0.602291745653602 VDDSSEDK(ub)TEFTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDDSSEDKTEFTVK 14 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 17634000.0 3713500.0 5181100.0 8739400.0 True False 5633650.99321507 4256492.224880933 7012053.759384913 1.0 0.7555477309487704 1.244673084617761 22.425638760308253 -6.770836139378924 1.5714202409078795 0.8599380171618378 1.2475007674343181 0.7336941075931687 0.1030469049121412 0.2650770437772826 1.291961776959196 0.051686566691379006 0.12293295883568012 1.694977199838207e-07 6.770836139378924 0.3875627502724803 VDDSSEDKTEFTVK(ub)NAQVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDDSSEDKTEFTVKNAQVR 19 2 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 106512600.0 9445600.0 38199000.0 58868000.0 True False 14329665.765857603 31382089.999850776 47232713.99723896 1.0 2.1900085118958543 3.2961490357840297 23.772501623876966 -6.972004045183369 0.2047382672944341 0.38054118793713193 5.136315290967095 0.9999940827416607 0.00228076146494741 0.07565763509020038 0.006649748437087219 0.034550681308880324 0.11606035597694243 1.0665861865960931e-07 6.972004045183369 4.755774103029963 VDDSSEDKTEFTVK(ub)NAQVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDDSSEDKTEFTVKNAQVR 19 2 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 9503400.0 1653400.0 2080800.0 5769200.0 True False 2264706.6614549416 1988863.3757145663 4406633.780403657 1.0 0.8781991105359481 1.9457856752064535 21.11089276508325 -6.878520503988321 1.0879829124527283 0.9258844633259116 2.0193408985677053 0.972473842214433 0.07916473246799394 0.12895032617391008 0.28025483576239407 0.05612208596316445 0.1352257630193343 1.3227552563792842e-07 6.878520503988321 1.0934564352417937 VDDSSEDKTEFTVK(ub)NAQVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDDSSEDKTEFTVKNAQVR 19 2 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 87243500.0 9445600.0 18865900.0 58932000.0 True False 12227515.400611823 17815996.080541063 48206980.69338349 1.0 1.457041393679178 3.9425001003042186 23.543627945969416 -6.937949905546336 0.678365575195997 0.9708649832722132 4.574174925883927 0.9978828924748719 0.05948972314901607 0.08871443436677365 0.05896237191870244 0.057046033884782424 0.21592181215396675 1.1535863125702854e-07 6.937949905546336 3.603309942611714 up VDDSSGSIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDDSSGSIGR 10 0 P41250 P41250 GARS Glycine--tRNA ligase 0 4829700.0 1558800.0 784300.0 2486600.0 False True 1509316.7472439809 1097475.0800704674 1835284.8635990098 1.0 0.7271337060789008 1.2159706482752863 20.525464172885666 -6.755203397734249 1.6302855470879125 0.8405600928161261 1.2173583305118774 0.6711309164040723 0.11470391602793233 0.29107595559235894 1.523523478817033 0.05554119922470629 0.1341267802274949 1.757100499738642e-07 6.755203397734249 0.37679823769575127 VDEAVAVLQAHQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDEAVAVLQAHQAK 14 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAS6;H0YB75;H0YAS7;H0YC10 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 8147170.0 799970.0 4373800.0 2973400.0 False True 1048768.4169204996 3721246.0889388677 2665741.0908668065 1.0 3.548205713388632 2.5417823876640244 20.00026471468923 -10.416025052941455 6.196128654972388 0.9995076325008618 3.0449940505262094 0.8462733335533338 0.41087060221002775 0.0027952339430043975 0.00026344659031818217 0.39789972491681985 0.13260791665047056 3.836851113913566e-11 10.416025052941455 2.0454864180253476 VDEAVAVLQAHQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDEAVAVLQAHQAK 14 0 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;Q9H361;H0YAS6;H0YB75;H0YAS7;H0YC10 P11940 PABPC1;PABPC3 Polyadenylate-binding protein 1;Polyadenylate-binding protein;Polyadenylate-binding protein 3 0 8305970.0 799970.0 3282700.0 4223300.0 False True 1095740.5273763814 3137659.4595627617 3225843.5215937644 1.0 2.863505895027456 2.9439848586395336 20.06347477621212 -10.527993745092857 0.606637357219305 5.966903274009997e-16 2.9341648491066343 0.9998386239713903 0.01140808931615212 1.9486226535868014 0.2966259680338154 3.050364214120215 0.013858493118612461 2.9648740906853155e-11 10.527993745092857 2.934164849106634 VDEEQMK(ub)YK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDEEQMKYK 9 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 2665680.0 785490.0 1149400.0 730790.0 True False 1029784.9966959801 977914.0003261091 655174.8610326744 1.0 0.9496292949146697 0.6362249043584576 19.97391172558793 -6.935070945295715 0.7039234302142242 1.0039897160668279 0.562703221868172 0.9974443838959497 0.00813560734058464 0.09008896949998929 0.06539879624229009 0.0076498643329575644 0.027609981393904928 1.1612588979012966e-07 6.935070945295715 -0.44128649419865584 VDEEQMK(ub)YK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDEEQMKYK 9 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 2509980.0 594710.0 539070.0 1376200.0 True False 575831.2565777954 754323.4622129127 1015731.934884964 1.0 1.309973110344702 1.7639402572926113 19.135286576095883 -6.965652135048431 0.34668385073305674 0.9544213537753181 2.134732710588891 0.9999259574264334 0.0026994794271859887 0.07774042010237654 0.014083937849523744 0.00628595031006244 0.03910706206814379 1.0823005146280282e-07 6.965652135048431 1.1803113568135728 VDEEQMK(ub)YK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VDEEQMKYK 9 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 15403830.0 2828190.0 3334240.0 9241400.0 True False 4290570.998384525 2739218.821463978 7414833.239350485 1.0 0.6384275711776688 1.7281693374010823 22.032738226774008 -6.8172688859776835 1.383612185659416 0.8045592042959655 1.7506014196055284 0.8779938406877774 0.15829952921814036 0.19705483043518202 0.7419727448227057 0.08992236894550033 0.20742640836600995 1.5231094547253856e-07 6.8172688859776835 0.9460422153095629 VDEEQMK(ub)YK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDEEQMKYK 9 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 2683030.0 785490.0 892140.0 1005400.0 True False 1075906.880069095 852722.3048875396 767945.2268629674 1.0 0.7925614388047947 0.7137655136229353 20.03712178711082 -13.999999999999998 0.1341979289915913 1.9870265074745526 0.6090823092830918 0.9996270417502793 0.0023314405453911434 11.932512998702729 0.11431446650874458 3.0958843220159005 0.09326832484947296 1.0000000000000041e-14 13.999999999999998 -1.3779441981914609 VDEEQMK(ub)YK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDEEQMKYK 9 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 2744600.0 594710.0 1176700.0 973190.0 True False 494527.71512010926 1170360.8835433375 1176679.5294778422 1.0 2.3666234424476777 2.3794005745300932 18.91569185153016 -10.82819503341418 0.8079573720731682 1.5100678390523052e-19 2.3766267928791427 0.9999884217460075 0.0022024305678222003 2.662310300530641 0.4325530778473227 5.124773720697635 0.0018348276205907516 1.485268486589789e-11 10.82819503341418 2.3766267928791427 VDEEQMK(ub)YK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VDEEQMKYK 9 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 19577660.0 2828190.0 2269770.0 14479700.0 True False 3661147.7069594734 2143455.3042118135 11844543.1742684 1.0 0.5854599365486731 3.2351994845094927 21.803864548866457 -6.866923050416812 1.1503239327556143 0.7694167319148283 3.381521384558235 0.9615105186782559 0.22831541578504366 0.13983516988943875 0.34777246915251164 0.1543126784384325 0.36349387899238667 1.358554137911093e-07 6.866923050416812 2.6121046526434064 up VDEIVLK(ub)NLHLNSHVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDEIVLKNLHLNSHVK 16 1 Q9Y2Z2-2;Q9Y2Z2-4;Q9Y2Z2-6;Q9Y2Z2;Q9Y2Z2-5;Q9Y2Z2-3 Q9Y2Z2-2 MTO1 Protein MTO1 homolog, mitochondrial 1 13194800.0 2519800.0 2744100.0 7930900.0 True False 3303482.2017779136 2334690.9764180225 7110286.546564714 1.0 0.7067363569149869 2.1523610881687216 21.655556141229944 -6.8538979543994865 1.2161971208797804 0.8428224617732631 2.2146243190927053 0.9457782012731544 0.14528926657999822 0.15322313038045685 0.4341821803241611 0.09337837101190917 0.21668333301164894 1.399916220395146e-07 6.8538979543994865 1.3718018573194422 up VDEIVLK(ub)NLHLNSHVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDEIVLKNLHLNSHVK 16 1 Q9Y2Z2-2;Q9Y2Z2-4;Q9Y2Z2-6;Q9Y2Z2;Q9Y2Z2-5;Q9Y2Z2-3 Q9Y2Z2-2 MTO1 Protein MTO1 homolog, mitochondrial 1 22519300.0 1915000.0 13096200.0 7508100.0 True False 1854209.3732180046 18325580.955780793 5541503.371828081 1.0 9.883231753907332 2.988607139985885 20.822372728416312 -6.582246654087293 2.2578723122602664 7.040916258982487 3.0061466482853967 0.0 3.856919425167537 0.6925891001367329 6.644178388308349 1.4322805206919247 4.309376446028632 2.616696454238911e-07 6.582246654087293 -4.03476961069709 VDEIVLK(ub)NLHLNSHVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDEIVLKNLHLNSHVK 16 1 Q9Y2Z2-2;Q9Y2Z2-4;Q9Y2Z2-6;Q9Y2Z2;Q9Y2Z2-5;Q9Y2Z2-3 Q9Y2Z2-2 MTO1 Protein MTO1 homolog, mitochondrial 1 12180500.0 2519800.0 3743600.0 5917100.0 True False 3451438.1550345747 3578195.373570279 4519602.846499773 1.0 1.036725913327117 1.3094839436445003 21.718766202752835 -6.931505506978736 0.7343201628612462 0.9960753610052403 1.3676906030795377 0.9968261496810858 0.007777443885406163 0.09186324511152773 0.07390297508939274 0.0071502178393541066 0.024478698028008165 1.1708317557432512e-07 6.931505506978736 0.3716152420742974 VDEIVLK(ub)NLHLNSHVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDEIVLKNLHLNSHVK 16 1 Q9Y2Z2-2;Q9Y2Z2-4;Q9Y2Z2-6;Q9Y2Z2;Q9Y2Z2-5;Q9Y2Z2-3 Q9Y2Z2-2 MTO1 Protein MTO1 homolog, mitochondrial 1 13871600.0 1915000.0 9756400.0 2200200.0 True False 1592407.3488843476 9703840.336706217 2660251.6474246033 1.0 6.093817856030871 1.6705848847585358 20.602778003850588 -6.6120194308326985 2.146797842216358 4.398672048417189 1.686825387266713 0.0565466546686898 2.1950114289587423 0.6070859772745919 5.305144243904875 0.8435919399849431 2.4353694124464798 2.443321233257123e-07 6.6120194308326985 -2.711846661150476 VDEIVLK(ub)NLHLNSHVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDEIVLKNLHLNSHVK 16 1 Q9Y2Z2-2;Q9Y2Z2-4;Q9Y2Z2-6;Q9Y2Z2;Q9Y2Z2-5;Q9Y2Z2-3 Q9Y2Z2-2 MTO1 Protein MTO1 homolog, mitochondrial 1 57159700.0 11626400.0 6981300.0 38552000.0 True False 15050603.99060656 6592784.517944093 31535931.576924615 1.0 0.4380411923706721 2.09532664580152 23.843318048656194 -6.815215640004738 1.3924414789619894 0.6955672314802159 2.127927852404941 0.8730260970784534 0.24521638778942736 0.19977112851106585 0.7623394170334513 0.1384316695998229 0.31954131640292854 1.530327420357981e-07 6.815215640004738 1.432360620924725 up VDELSLYSVPEGQSK(ub)YVEEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDELSLYSVPEGQSKYVEEAR 21 1 H7C1U8;Q9BUR5;Q9BUR5-2;G3V1B6 H7C1U8 APOO Apolipoprotein O 1 26206000.0 7938800.0 9958800.0 8308400.0 True False 10407843.679448558 8472985.859098366 7448726.467800408 1.0 0.8140961874580435 0.7156839300448703 23.3111678629923 -13.999999999996442 0.0794793662396963 2.005625050034728 0.4189519402536669 0.9998888190318366 0.0012430387291868785 12.263651971086407 0.07917173454802928 2.17344560038393 0.2696561547451083 1.0000000000081926e-14 13.999999999996442 -1.5866731097810614 VDELSLYSVPEGQSK(ub)YVEEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDELSLYSVPEGQSKYVEEAR 21 1 H7C1U8;Q9BUR5;Q9BUR5-2;G3V1B6 H7C1U8 APOO Apolipoprotein O 1 23098200.0 10514000.0 7255300.0 5328900.0 True False 10180238.825072628 10152379.125889674 3933101.226426751 1.0 0.9972633550487697 0.3863466559094886 23.279268071175867 -6.907880674951896 0.9100204895988766 1.0202066291159841 0.3108663788014867 0.9900974357232292 0.028722646832677327 0.10583721596241497 0.14648320729019568 0.02327187350994473 0.06333764671843951 1.2362870641683502e-07 6.907880674951896 -0.7093402503144974 down VDELSLYSVPEGQSK(ub)YVEEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDELSLYSVPEGQSKYVEEAR 21 1 H7C1U8;Q9BUR5;Q9BUR5-2;G3V1B6 H7C1U8 APOO Apolipoprotein O 1 76613000.0 21785000.0 24486000.0 30342000.0 True False 33049437.69683323 20116281.990008816 24344890.400628958 1.0 0.6086724432209127 0.7366204116374926 24.978122390138413 -10.89624360953738 10.978298632763453 1.023765581462171 0.6726464274292179 0.8972021156411601 0.05223453937439306 0.023952527371539703 0.00022637600225994814 0.03987047412162 0.01685862509115333 1.2698615997814651e-11 10.89624360953738 -0.351119154032953 VDELSLYSVPEGQSK(ub)YVEEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDELSLYSVPEGQSKYVEEAR 21 1 H7C1U8;Q9BUR5;Q9BUR5-2;G3V1B6 H7C1U8 APOO Apolipoprotein O 1 23606300.0 7938800.0 9998500.0 5669000.0 True False 10873988.898003196 9556733.209381994 4330098.956719884 1.0 0.8788617773130988 0.39820704226716885 23.37437792451519 -6.945061078297821 0.6106745399610878 1.0053115447394478 0.24669766370796806 0.9987543790475053 0.009172183912519817 0.08553189962481902 0.04465367892533111 0.009317368912251945 0.04053959643878596 1.134851201270301e-07 6.945061078297821 -0.7586138810314798 down VDELSLYSVPEGQSK(ub)YVEEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDELSLYSVPEGQSKYVEEAR 21 1 H7C1U8;Q9BUR5;Q9BUR5-2;G3V1B6 H7C1U8 APOO Apolipoprotein O 1 25356400.0 10514000.0 9369000.0 5473400.0 True False 8742856.849174943 9318527.337399112 6617862.633857761 1.0 1.0658446658975658 0.7569450979266902 23.059673346610143 -6.850979486544149 1.2304142595703111 1.0351676084664698 0.7443653582636238 0.9417102402900481 0.03207312982453628 0.15638379819733342 0.45510805700974 0.02039249772091313 0.04721820361008151 1.409355366309601e-07 6.850979486544149 -0.290802250202846 VDELSLYSVPEGQSK(ub)YVEEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDELSLYSVPEGQSKYVEEAR 21 1 H7C1U8;Q9BUR5;Q9BUR5-2;G3V1B6 H7C1U8 APOO Apolipoprotein O 1 55137000.0 21785000.0 13994000.0 19358000.0 True False 28201111.946549572 13215221.598285345 15835042.629853355 1.0 0.4686064018799173 0.5615041938724258 24.749248712230862 -10.439774549881188 6.726661539741583 1.0000826496698574 0.5150552978762957 0.9732147141732725 0.037925364768809124 4.701641641113095e-05 3.915735708016384e-06 0.036727274166867566 0.012240358845703264 3.632665840840514e-11 10.439774549881188 -0.4850273517935617 VDENFDCVEADDVEGK(ub)IR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDENFDCVEADDVEGKIR 18 1 O14929;O14929-2 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 17037900.0 4162600.0 7731400.0 5143900.0 True False 5457208.9106757445 6577905.256761155 4611658.571772978 1.0 1.2053607190835285 0.8450580960445464 22.379731842762947 -6.752061994852529 1.6418813793173042 1.120449107702858 0.8442120441790534 0.6579747079100027 0.08630454639842748 0.29643942683738467 1.5728482138208983 0.041510186073267036 0.10057146041407988 1.769856296088593e-07 6.752061994852529 -0.2762370635238046 VDENFDCVEADDVEGK(ub)IR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDENFDCVEADDVEGKIR 18 1 O14929;O14929-2 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 40887000.0 13851000.0 15541000.0 11495000.0 True False 21012979.64373824 12767587.127612771 9223008.211562514 1.0 0.6076047920894192 0.43891958056081415 24.324777415106407 -13.999999999999956 0.11516136292899617 2.8790041796053436 0.15125840159224732 0.9997169757819456 0.003954331582784697 11.984848553160274 0.10378309229424777 5.190056166644957 0.25528038556303273 1.0000000000001022e-14 13.999999999999956 -2.7277457780130963 VDENFDCVEADDVEGK(ub)IR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDENFDCVEADDVEGKIR 18 1 O14929;O14929-2 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 17402000.0 4162600.0 6138800.0 7100600.0 True False 5701625.710035288 5867567.517703084 5423584.521447372 1.0 1.0291042969333688 0.9512347525551278 22.44294190428584 -6.805482463543887 1.4334698173539193 1.0159481803552575 0.9500091315151885 0.8476992766509066 0.012537441517047831 0.21302320491388002 0.8635260401866578 0.006878949187668122 0.015947206668357684 1.5650115118343684e-07 6.805482463543887 -0.06593904884006896 VDENFDCVEADDVEGK(ub)IR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDENFDCVEADDVEGKIR 18 1 O14929;O14929-2 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 1 28188500.0 13851000.0 4667900.0 9669600.0 True False 17930392.544028394 4408127.261586118 7909832.018474523 1.0 0.24584666792775917 0.4411410402227275 24.095903737198856 -10.388246471729696 5.1023370953284015 1.0004964392097635 0.3434938540769339 0.937761982173694 0.07972859362680897 0.00045057205922278997 5.402232612145829e-05 0.07725259006066458 0.025732292944405714 4.090284611435634e-11 10.388246471729696 -0.6570025851328296 VDENGK(ub)ISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDENGKISR 9 1 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 295019300.0 0.0 321350.0 294697950.0 True False 0.0 273405.83261248923 264205433.07634723 0.0 VDENGK(ub)ISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDENGKISR 9 1 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 398915680.0 175680.0 0.0 398740000.0 True False 170103.13456237028 0.0 294298032.0564096 1.0 0.0 1730.1152786723153 17.376050200834467 -9.987653245364463 17.374444514954025 1.0078943288611912 199.99999995849788 0.0 890.9270015362619 0.0 0.0 1063.5577136901475 354.5193060345418 1.0288374270558736e-10 9.987653245364463 198.99210562963668 VDENGK(ub)ISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDENGKISR 9 1 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 3069490000.0 1893030000.0 162460000.0 1014000000.0 True False 2871864909.030809 133467743.69422656 813582455.5480112 1.0 0.046474241624153895 0.28329412466082093 31.419340741150314 -10.360270676139638 5.061341258046679 1.0004829012041423 0.1648841831423774 0.9431185747773483 0.09668131239795749 0.0005271148310032439 6.662478119396865e-05 0.09366239675933963 0.03120375940050846 4.362438563971044e-11 10.360270676139638 -0.8355987180617649 VDENGK(ub)ISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDENGKISR 9 1 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 VDENGK(ub)ISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDENGKISR 9 1 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 484325680.0 175680.0 0.0 484150000.0 True False 146085.70394360428 0.0 585383526.5433246 1.0 0.0 4007.123974083797 17.156455476268743 -12.378984153644444 20.036489550460214 2.078077383386966 199.99999994191197 0.0 2204.071531994031 0.0 0.0 0.0 859.9283008530676 4.178456125445624e-13 12.378984153644444 197.921922558525 VDENGK(ub)ISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDENGKISR 9 1 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 2732241000.0 1893030000.0 638600000.0 200611000.0 True False 2450564652.1999865 603061348.6254843 164101856.44268563 1.0 0.24609077262421458 0.06696491614508669 31.190467063242764 -11.338973497680142 0.2648734959042191 2.229269872639754 4.324594249688184e-13 0.9992364106099818 0.011171664093800293 3.703424575034524 0.14824106294541478 2.7265245846783737 0.0757461941694969 4.581698451478225e-12 11.338973497680142 -2.2292698726393216 VDENGKISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDENGKISR 9 1 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 0 42365500.0 13578000.0 20482000.0 8305500.0 False True 17800889.489539042 17426165.43821068 7446126.531981648 1.0 0.9789491389433898 0.4183008122351119 24.085445996981008 -6.914837095815148 0.862141324504013 1.0148177401734064 0.3378175135075349 0.9926225325610933 0.02313858145500826 0.101305828777782 0.12205866966749734 0.019409131034898112 0.05555607136251903 1.216642278494194e-07 6.914837095815148 -0.6770002266658715 down VDENGKISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDENGKISR 9 1 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 0 61845000.0 22867000.0 28240000.0 10738000.0 False True 22141099.60176297 39516379.26965455 7925395.666905066 1.0 1.7847523375265466 0.3579495060974303 24.400223537217045 -6.757345265607095 1.6222354324814163 1.457308016271968 0.35335598914172406 0.6801923290063527 0.32995568393159214 0.2873641555656868 1.4898113294536857 0.16052282875979063 0.38681465725512104 1.7484561073193919e-07 6.757345265607095 -1.1039520271302439 VDENGKISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDENGKISR 9 1 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 0 22606800.0 9967200.0 3570200.0 9069400.0 False True 15120971.099925453 2933069.9159000837 7276829.114740771 1.0 0.1939736473614809 0.481240858583259 23.85004745959447 -10.40466078370211 5.920881349775669 1.0001977801517536 0.3376072529950604 0.8763785125177521 0.11727634788761392 0.0003062722248580613 3.0795377070618354e-05 0.11358540751155313 0.037850778522729445 3.938575874204492e-11 10.40466078370211 -0.6625905271566932 VDENGKISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDENGKISR 9 1 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 0 38117700.0 13578000.0 17074000.0 7465700.0 False True 18598153.531653076 16319614.223832399 5702455.420917899 1.0 0.8774857243788894 0.30661406312259015 24.1486560585039 -6.941389539288218 0.6465084040793262 1.0062857832606766 0.1461648405367163 0.9983402825718255 0.012309752340594504 0.08713842984780493 0.051765759288580855 0.012112743909065636 0.048840842923782095 1.1444859372921232e-07 6.941389539288218 -0.8601209427239603 down VDENGKISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDENGKISR 9 1 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 0 16711200.0 9967200.0 5586300.0 1157700.0 False True 12902736.882884955 5275417.494247637 947010.4790051248 1.0 0.4088603481673179 0.07339609321657192 23.62117378168692 -8.510739170003792 0.3914694211774313 1.1047189100275305 7.513488298972289e-21 0.9970750097541695 0.020716807444734232 0.19344299370212323 0.11979011565327102 0.10050149514704304 0.08017103914198838 3.0850402174876962e-09 8.510739170003792 -1.1047189100275305 VDEVK(ub)STIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDEVKSTIK 9 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 43742000.0 15996000.0 14001000.0 13745000.0 True False 20970910.905484345 11912105.375470536 12322799.251350047 1.0 0.5680299453446852 0.5876139242061903 24.32188619280309 -10.77736708344886 10.785944546197452 1.0016756733901062 0.5778219347806788 0.9983887175111661 0.007995125890689883 0.0003228820783375771 6.664610537891689e-06 0.007758537123912905 0.0025804157854561346 1.669678736986208e-11 10.77736708344886 -0.42385373860942743 VDEVK(ub)STIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDEVKSTIK 9 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 52550000.0 16475000.0 17632000.0 18443000.0 True False 15952010.142959062 24672549.549665283 13612225.021859786 1.0 1.5466733865233477 0.8533234933948424 23.927234896386768 -6.6965344458840415 1.8434748967012873 1.340620334492878 0.8555341528085476 0.4009853929916879 0.23090895746619106 0.40280342988410306 2.6588772121550517 0.10002650878089875 0.25832436987339275 2.0112476706120816e-07 6.6965344458840415 -0.4850861816843304 VDEVK(ub)STIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDEVKSTIK 9 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 78492000.0 25400000.0 21338000.0 31754000.0 True False 38533656.988733694 17530067.185445048 25477807.981727365 1.0 0.4549287183038561 0.6611832349360576 25.199615773882773 -10.147375923941329 5.286289687794519 1.0000137451474882 0.5580559766197289 0.8595825002195405 0.08420305381634953 1.3640900275625594e-05 2.2001773672356343e-06 0.08153178944487106 0.02717641876076157 7.122362537579295e-11 10.147375923941329 -0.44195776852775925 VDEVK(ub)STIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDEVKSTIK 9 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 44224000.0 15996000.0 12387000.0 15841000.0 True False 21910153.475646082 11839701.381668746 12099682.055635842 1.0 0.5403751002853082 0.5522408626249501 24.38509625432598 -9.943065690888178 5.228226593750726 1.0000013516649857 0.5463079814514504 0.9994872470677576 0.004844177203059141 7.632343205181174e-08 1.542693915760076e-08 0.0046903683799066126 0.0015634514676096396 1.140077327721711e-10 9.943065690888178 -0.4536933702135353 VDEVK(ub)STIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDEVKSTIK 9 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 49181000.0 16475000.0 18817000.0 13889000.0 True False 13699692.466250448 18715629.08611795 16793125.68451973 1.0 1.3661349794693853 1.2258031138939824 23.707640171821044 -10.180633176202736 5.301341842519238 0.9999865877183044 1.2959690466817788 0.8557180591963591 0.05729024421909545 9.082195674896066e-06 1.403715104864366e-06 0.05547355267644882 0.01849034681334468 6.597308970662895e-11 10.180633176202736 0.2959824589634744 VDEVK(ub)STIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDEVKSTIK 9 1 P62906 P62906 RPL10A 60S ribosomal protein L10a 1 74794000.0 25400000.0 17484000.0 31910000.0 True False 32880800.70885282 16511000.030328788 26102707.4242494 1.0 0.5021471398013544 0.7938586306148412 24.970742095975222 -10.258699108498732 5.748678989288998 1.0000192769465865 0.6480028852080955 0.660023174134535 0.11909071743328578 2.9424515180583945e-05 3.7942629256768025e-06 0.1153153984666738 0.03843636377558195 5.5118944378472583e-11 10.258699108498732 -0.3520163917384911 VDFNVPMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDFNVPMK 8 0 P00558;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 15806700.0 6319700.0 1814700.0 7672300.0 False True 6119084.582728888 2539319.173535482 5662694.465933671 1.0 0.41498350598105943 0.9254152952741693 22.544884410683498 -10.33513765645747 8.373686417020732 1.000000893105297 0.6701994006276183 0.35758635912836245 0.20838290537732285 3.474300279929581e-06 2.761085328418741e-07 0.20176642466584183 0.06725529351339057 4.6223448569656776e-11 10.33513765645747 -0.32980149247767876 VDFNVPMK(ub)NNQITNNQR ddPTM_RPMI8226_Bortezomib_1h_R1 2 VDFNVPMKNNQITNNQR 17 1 P00558 P00558 PGK1 Phosphoglycerate kinase 1 1 95291900.0 25513600.0 45168300.0 24610000.0 True False 33448576.67405389 38429365.704654396 22063593.27578935 1.0 1.1489088483237049 0.6596272687711735 24.995441485871314 -6.825054485975161 1.3499368948458526 1.079876456660175 0.6477488805738282 0.8956018833000218 0.06616674613658903 0.18699407906532214 0.6681695734270957 0.03850331211353993 0.08864409133297071 1.4960479522472294e-07 6.825054485975161 -0.4321275760863469 VDFNVPMK(ub)NNQITNNQR ddPTM_RPMI8226_Bortezomib_2h_R1 2 VDFNVPMKNNQITNNQR 17 1 P00558 P00558 PGK1 Phosphoglycerate kinase 1 1 177067400.0 70528700.0 60162800.0 46375900.0 True False 68289805.02395861 84186119.78485738 34228660.542822026 1.0 1.2327772755438642 0.5012265085661518 26.025166879048747 -6.821108016954491 1.3669811405489827 1.125328146057367 0.4848601725904622 0.8869340638994798 0.10261231718053355 0.19204362025791294 0.7048220842248806 0.05898216096633402 0.13591203570022617 1.5097046164057318e-07 6.821108016954491 -0.6404679734669048 VDFNVPMK(ub)NNQITNNQR ddPTM_RPMI8226_Bortezomib_8h_R1 2 VDFNVPMKNNQITNNQR 17 1 P00558 P00558 PGK1 Phosphoglycerate kinase 1 1 261396900.0 85476000.0 71190900.0 104730000.0 True False 129673341.13263813 58486327.677959494 84030069.59521025 1.0 0.45102815403002505 0.6480134533532144 26.950306673006732 -10.25813555465326 5.065071131436453 1.0000787185760671 0.5495208036914324 0.8745769273965474 0.08041891169587592 7.14989041141049e-05 1.0472165335120199e-05 0.07787881629677755 0.025955092143091427 5.5190514837919664e-11 10.25813555465326 -0.4505579148846347 VDFNVPMK(ub)NNQITNNQR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VDFNVPMKNNQITNNQR 17 1 P00558 P00558 PGK1 Phosphoglycerate kinase 1 1 104156400.0 25513600.0 59674600.0 18968200.0 True False 34946667.39911506 57037978.85448688 14488301.82234152 1.0 1.6321435804757516 0.41458321781802865 25.058651547394206 -6.765583803248649 1.5911806069347103 1.3646171496079318 0.40881897200168726 0.7134618981358282 0.26614152821223436 0.2736246219412531 1.3664679484409334 0.1318896790115685 0.3152638523647403 1.715600628828301e-07 6.765583803248649 -0.9557981776062445 VDFNVPMK(ub)NNQITNNQR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VDFNVPMKNNQITNNQR 17 1 P00558 P00558 PGK1 Phosphoglycerate kinase 1 1 202312100.0 70528700.0 106493000.0 25290400.0 True False 58647739.001179904 105919301.07179451 30578505.710402317 1.0 1.8060253110467495 0.5213927464413781 25.805572154483023 -6.7371115979542795 1.6974575826454705 1.481194246707753 0.5211371755801009 0.591781961444309 0.3386890768492715 0.323090314260805 1.8267907263673384 0.15792522076039245 0.3887419546165182 1.8318436444092544e-07 6.7371115979542795 -0.9600570711276522 VDFNVPMK(ub)NNQITNNQR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VDFNVPMKNNQITNNQR 17 1 P00558 P00558 PGK1 Phosphoglycerate kinase 1 1 230130500.0 85476000.0 107351000.0 37303500.0 True False 110650366.98385473 101376822.48088698 30514645.766232774 1.0 0.9161905671372886 0.27577536883077164 26.721432995099182 -6.930959819802644 0.7388700307705086 1.0094001579170546 0.14102865398406061 0.9967235644727452 0.018515093035970355 0.09214248677736112 0.07526072808371519 0.01696548006785673 0.05764372019277047 1.1723038201150647e-07 6.930959819802644 -0.868371503932994 down VDFPQDQLTALTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDFPQDQLTALTGR 14 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 13413500.0 4103200.0 2399900.0 6910400.0 False True 3972946.161978125 3358192.5853131684 5100358.932443737 1.0 0.8452650623488762 1.283772476268411 21.921777812693946 -6.811347368080827 1.4089336292533425 0.9158035845242549 1.291677008720534 0.8632903790147249 0.06713976953080306 0.20497547391284127 0.801708991309926 0.03746745906082744 0.08661532257841044 1.5440189703314115e-07 6.811347368080827 0.3758734241962791 VDFPTAIGMVVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDFPTAIGMVVER 13 0 O96019;H7C5S0 O96019 ACTL6A Actin-like protein 6A 0 16963300.0 4444500.0 6259700.0 6259100.0 False True 5826782.540599223 5325777.1601194935 5611468.37352674 1.0 0.9140168048165727 0.9630475025329605 22.474268038675397 -10.164529792878099 4.123733638089158 1.0000204442186487 0.9385321536646843 0.6769558899298265 0.02001669857416645 28044746.88176984 0.38696256842219584 5871.343825654809 0.006852248327132586 6.84652513881525e-11 10.164529792878099 -0.06148829055396432 VDFPTAIGMVVER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDFPTAIGMVVER 13 0 O96019;H7C5S0 O96019 ACTL6A Actin-like protein 6A 0 17846100.0 6148500.0 3391000.0 8306600.0 False True 5953319.233018736 4745043.983831393 6130852.267341557 1.0 0.7970417506781899 1.0298208490715859 22.505262826959925 -6.676288345165809 1.9152376682350474 0.8711575296919135 1.0289069239414916 0.30710705303342556 0.08608976706948027 0.4468474040536227 3.165756360880922 0.036112727527371456 0.09569449437233704 2.107228613531737e-07 6.676288345165809 0.15774939424957812 VDFPTAIGMVVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDFPTAIGMVVER 13 0 O96019;H7C5S0 O96019 ACTL6A Actin-like protein 6A 0 18439300.0 4444500.0 6014300.0 7980500.0 False True 6087751.758096337 5748568.339369527 6095670.263556714 1.0 0.944284288813893 1.0013007273908379 22.53747810019829 -10.006244698102671 4.358980625179468 1.000000935833294 0.9727925081265267 0.23289919572695317 0.023276863598136004 32104607.244551424 5.552394361132524 408.4097837628721 0.00796828953483696 9.857239346137133e-11 10.006244698102671 -0.027208427706767235 VDFPTAIGMVVER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDFPTAIGMVVER 13 0 O96019;H7C5S0 O96019 ACTL6A Actin-like protein 6A 0 11526300.0 6148500.0 2533900.0 2843900.0 False True 5112750.1747338865 2520249.3777602306 3438546.34129208 1.0 0.4929341922894574 0.6725433912817875 22.2856681023942 -10.177386317041487 6.290904158642842 1.0000027888384542 0.5827387917856218 0.8779908539422869 0.07332514844020596 2.868057222027495e-06 3.751056950524284e-07 0.0709972435305231 0.0236655898972582 6.646816403181261e-11 10.177386317041487 -0.41726399705283235 VDGMDILCVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDGMDILCVR 10 0 P08559;P08559-4;P08559-3;P08559-2 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 0 4754700.0 1164000.0 3590700.0 0.0 False True 1594362.2559172313 3432051.001142965 0.0 1.0 2.1526168149085527 0.0 20.604548031424134 -6.7653420367687565 1.6188865083037245 1.6682856289010985 6.223831456242795e-09 0.6958853509584673 0.48503525185775115 0.27779850914744997 1.44041221139785 0.23732532172598542 0.5613860970987371 1.7165559488097464e-07 6.7653420367687565 -1.668285622677267 VDIAEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDIAEGR 7 0 Q15056-2;Q15056 Q15056-2 EIF4H Eukaryotic translation initiation factor 4H 0 5239710.0 1815400.0 464310.0 2960000.0 False True 1757771.1206997186 649711.4043446636 2184687.2019034284 1.0 0.3696222999078697 1.242873532382172 20.74531579877682 -6.712988850328016 1.7843767883625596 0.613666967902895 1.2410308126055074 0.47947860209855975 0.2655141407819368 0.36904010084013184 2.292264018117243 0.11832853552953373 0.29954518263830054 1.9364716784784955e-07 6.712988850328016 0.6273638447026124 VDIDAPDVDVHGPDWHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDIDAPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 63341500.0 7761500.0 29602000.0 25978000.0 False True 10175401.662472913 25185496.98769224 23290045.75857198 1.0 2.4751354121554594 2.288857632467339 23.278582408582228 -10.0725713249525 4.520988021606411 0.9999137330281078 2.3819965223563067 0.9865571387063136 0.076047585362035 13197983.256899644 2.232039218481555 12177.813908221915 0.026033111178772453 8.461135986599771e-11 10.0725713249525 1.3820827893281988 VDIDAPDVDVHGPDWHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDIDAPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 66526000.0 18054000.0 10949000.0 37523000.0 False True 17480885.65225995 15320992.798280692 27694600.634129126 1.0 0.8764425958189352 1.5842790339715274 24.059274943658483 -6.8618668885877865 1.1763653012212014 0.9326091908131187 1.6197823252287427 0.9558640063730438 0.06485419203036509 0.14488520451702966 0.3799428358139338 0.04296805674857752 0.10051376459865102 1.37446318391058e-07 6.8618668885877865 0.687173134415624 VDIDAPDVDVHGPDWHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDIDAPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 196508700.0 5572700.0 180860000.0 10076000.0 False True 8454193.318941586 148584119.9343701 8084474.183532308 1.0 17.575197813547508 0.9562679582236517 23.01123567164906 -6.537301489515237 2.4419859552525987 9.999999999999998 0.9650839180187059 0.24525089368758834 6.797159200101115 0.5620926367124314 6.267117911951433 2.615839369561076 8.381945767104835 2.9020073662452413e-07 6.537301489515237 -9.034916081981292 VDIDAPDVDVHGPDWHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDIDAPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 80858500.0 7761500.0 34484000.0 38613000.0 False True 10631136.296650853 32960382.856661413 29493404.659697402 1.0 3.1003631161275758 2.774247628542658 23.34179247010512 -10.302860187321754 5.386202553846615 0.9996593865110394 2.9373053723352056 0.9791898668976888 0.13313609030064408 0.0005446412545199973 7.049303910524411e-05 0.12892879072189448 0.042969488376084976 4.9789734756707246e-11 10.302860187321754 1.9376459858241661 VDIDAPDVDVHGPDWHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDIDAPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 31587400.0 18054000.0 7779100.0 5754300.0 False True 15012700.927810948 7737192.444269552 6957497.525122905 1.0 0.5153764456824984 0.4634407598325081 23.83968021909276 -13.999999999999998 0.31544683029843723 5.83686782464426 0.45259790497643915 0.999683898953547 0.004295941006218995 17.66672328225093 0.17891799840320396 56.25603016054202 0.01760520614447577 1.0000000000000041e-14 13.999999999999998 -5.384269919667821 VDIDAPDVDVHGPDWHLKMPK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDIDAPDVDVHGPDWHLKMPK 21 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 10081200.0 3204600.0 5151200.0 1725400.0 True False 4201261.63339054 4382661.039220332 1546872.159205485 1.0 1.0431773647201774 0.36819229416976684 22.002391201718886 -6.891638167038643 1.012620224871197 1.0348562003609334 0.30823446440095703 0.9819269962222164 0.041475883666645626 0.11782489546968385 0.2141540802076743 0.03113907399893313 0.07810396102109855 1.2833994030806008e-07 6.891638167038643 -0.7266217359599764 down VDIDAPDVEVHDPDWHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDIDAPDVEVHDPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9991900.0 3324100.0 1377000.0 5290800.0 False True 3218578.2650203463 1926843.280960138 3904980.7594022457 1.0 0.598662863631796 1.2132626389240717 21.61799212009937 -6.730487158449212 1.721259814649894 0.7586094699484477 1.2129422271867725 0.5615890747776737 0.16870654129939225 0.3353356842172744 1.9465654087046198 0.07766140272259903 0.19261957400422575 1.8599995602964252e-07 6.730487158449212 0.4543327572383248 VDIDAPDVSIEGPDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDIDAPDVSIEGPDAK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9628870.0 851970.0 4465700.0 4311200.0 False True 1116940.920489216 3799434.967162264 3865118.379950547 1.0 3.4016436299049064 3.46045015367298 20.091121447203268 -10.458235937794955 0.7181321386103149 6.127570487858806e-22 3.449804085985699 0.9999326765190718 0.00940514628607292 1.854901194835243 0.36647100433262125 3.5265774202281857 0.009011864837620133 3.4814812631492944e-11 10.458235937794955 3.449804085985699 VDIDAPDVSIEGPDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDIDAPDVSIEGPDAK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 10481700.0 2909400.0 1273100.0 6299200.0 False True 2817042.6895250403 1781455.4691287936 4649250.548050705 1.0 0.6323849744105763 1.6504011690481621 21.425749995834114 -6.809021935411257 1.4186540488862598 0.7994219653574751 1.6678134181936866 0.8572589460039886 0.15902598953236435 0.20813504977094624 0.82577822277661 0.08814707786924396 0.20399290886443264 1.5523086037407129e-07 6.809021935411257 0.8683914528362114 VDIDAPDVSIEGPDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDIDAPDVSIEGPDAK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 12201270.0 851970.0 6025400.0 5323900.0 False True 1166966.332623543 5759177.904666737 4066504.4691622793 1.0 4.935170573189635 3.4846801964029854 20.15433150872616 -9.50365149739125 9.17823772650523 1.000001563670929 4.209925384763928 0.8671940900023656 0.5921602166581429 0.0 0.0 0.573356655806904 0.19111888811685682 3.1358010601909915e-10 9.50365149739125 3.2099238210929997 VDIDTPDINIEGSEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDIDTPDINIEGSEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 17569100.0 6177100.0 2547600.0 8844400.0 False True 5981011.341673596 3564869.96555849 6527786.313687391 1.0 0.5960313000444795 1.0914184810525367 22.511958022686123 -6.689889898671024 1.866871346611007 0.7467121029556405 1.0897018979411657 0.3699118587642405 0.17085385281581797 0.41688797883983364 2.816931364397418 0.07321739906620953 0.190685152549805 2.0422556269520522e-07 6.689889898671024 0.3429897949855252 VDIDVPDVDVQGPDWHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDIDVPDVDVQGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 6859600.0 1660900.0 2922000.0 2276700.0 False True 2177455.9841784816 2486048.98986679 2041128.9236485008 1.0 1.1417218111091854 0.9373915883854641 21.054212125324323 -6.720146217653471 1.758682574217958 1.0862085901820397 0.9377055304202668 0.5132258715301605 0.05963610531121139 0.35504886871708613 2.1462095662634493 0.02692314677505536 0.06757825737219711 1.904819298119142e-07 6.720146217653471 -0.14850305976177292 VDIDVPDVDVQGPDWHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDIDVPDVDVQGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 28702300.0 8989400.0 7620900.0 12092000.0 False True 8704036.417548772 10663965.112468477 8924742.44777576 1.0 1.225174689178479 1.025356744806583 23.053253162137967 -10.683397576666637 3.1596764994393207 0.9874842258484321 1.1252657169031601 0.34383354053435367 0.081575334380907 60538234.69334631 54454509.25520263 5984493.69205926 0.029853508898523146 2.0730148985377613e-11 10.683397576666637 0.13778149105472803 VDIDVPDVDVQGPDWHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDIDVPDVDVQGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 11295100.0 1660900.0 3202500.0 6431700.0 False True 2274979.614134823 3061002.960748697 4912664.92501945 1.0 1.345507863776089 2.1594325041403684 21.117422186847215 -6.956722773366478 0.47939806878513586 0.980352408647518 2.5584878740133914 0.9996286645242067 0.00936606291738639 0.0808933290009115 0.025620224064983675 0.01146212446223042 0.06714331308394733 1.1047836201351447e-07 6.956722773366478 1.5781354653658735 up VDIDVPDVNIEGPDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDIDVPDVNIEGPDAK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 22815700.0 1501500.0 12777000.0 8537200.0 False True 1968481.0405466827 10870721.404355912 7653852.438605 1.0 5.522390706560687 3.8882022640560394 20.90865138655011 -10.151392635002166 5.870447333270842 0.9999613528246393 4.705296485308463 0.8726856291571377 0.6671546379486802 0.0003374613499494201 4.8778425294926676e-05 0.6459762586182701 0.21532323350997137 7.056792784330773e-11 10.151392635002166 3.705335132483824 VDIDVPDVNIEGPDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDIDVPDVNIEGPDAK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 32510800.0 13961000.0 4813800.0 13736000.0 False True 13517815.696865022 6735975.443635371 10138129.528832924 1.0 0.4983035421319985 0.7499828194272616 23.688358713916685 -10.248452019387598 4.846135251147846 1.0000856872308301 0.6241431807790814 0.7483416997491219 0.10274763470292038 9.514520249573817e-05 1.4755461767954129e-05 0.09950755677607544 0.03316165650527376 5.643492868958899e-11 10.248452019387598 -0.37594250645174876 VDIDVPDVNIEGPDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDIDVPDVNIEGPDAK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 28292500.0 1501500.0 13266000.0 13525000.0 False True 2056645.1265117894 12679864.255204432 10330673.556118598 1.0 6.165314614442185 5.023070544814956 20.971861448073 -9.904607193151378 6.850685303876914 0.9999998561142461 5.594192579628617 0.9556923413707632 0.4663191887179695 1.024361207500487e-06 1.6106414372387622e-07 0.4515116129779568 0.15050387099344598 1.2456407485907085e-10 9.904607193151378 4.594192723514371 VDIDVPDVNLEAPEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDIDVPDVNLEAPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 12174200.0 5302000.0 2091600.0 4780600.0 False True 5133690.912168064 2926786.7875499045 3528417.445074167 1.0 0.570113557209439 0.6873061712209789 22.29156500647125 -10.264773581620634 8.196071716554199 1.00000034973972 0.6287098642152134 0.9304752023715903 0.04784368432520253 3.057447459442201e-07 2.7456364470501422e-08 0.046324491639320904 0.015441482717726192 5.43533627582315e-11 10.264773581620634 -0.3712904855245067 VDIDVPDVNVQGPDWHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDIDVPDVNVQGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7261900.0 1658800.0 3522600.0 2080500.0 False True 2174702.863842052 2997041.810987255 1865229.8175652092 1.0 1.3781385313910772 0.8576941009172646 21.05238686401156 -6.7118350535107005 1.7884591038249424 1.2320330660451362 0.8588392854509087 0.47387869214810774 0.15930068583827406 0.3714137391949534 2.316872380043687 0.07084897844905852 0.17960407641248363 1.9416231725118656e-07 6.7118350535107005 -0.3731937805942275 VDIDVPDVNVQGPDWHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDIDVPDVNVQGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 26490700.0 6166000.0 5555700.0 14769000.0 False True 5970263.705097755 7774119.982592766 10900555.839497207 1.0 1.3021401342715857 1.8258081012719227 22.509363225711166 -6.962745177630925 0.3948434188946864 0.9695239212157278 2.1773871269529037 0.999858857120194 0.004053029784119992 0.07873467158588078 0.017611755109591874 0.00674626955285608 0.04396221481095525 1.0895692107536414e-07 6.962745177630925 1.2078632057371759 VDIDVPDVNVQGPDWHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDIDVPDVNVQGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 14225900.0 1658800.0 3421900.0 9145200.0 False True 2272103.187384456 3270709.1432899195 6985292.111306168 1.0 1.4395073082288197 3.0743727442006388 21.11559692553445 -6.9465449136059885 0.5955692360324052 0.9813913517779855 3.6155436326502963 0.9989014948466072 0.029580689137244785 0.08490351937214113 0.041938002157308814 0.030494067898157826 0.13719526104480406 1.1309804202314064e-07 6.9465449136059885 2.6341522808723106 up VDIDVPDVNVQGPDWHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDIDVPDVNVQGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 14454900.0 6166000.0 4575300.0 3713600.0 False True 5127302.200115339 4550651.950774053 4490096.590253613 1.0 0.8875333992741223 0.8757230245084068 22.289768501145442 -13.999999999999998 0.3183877771165692 2.142186081038816 0.8733358910034081 0.9996902506894124 0.0009857230071233503 17.888965836462376 0.17987461947355213 13.598578697087682 0.003957019366630811 1.0000000000000041e-14 13.999999999999998 -1.2688501900354077 VDIEAPDVSLEGPEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDIEAPDVSLEGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 13363700.0 5625300.0 1884600.0 5853800.0 False True 5446727.930633542 2637130.608059169 4320514.169764288 1.0 0.4841678603455466 0.7932311334048482 22.376958374279507 -10.327262006166263 5.930638049809319 1.0000369915920166 0.6386994968752002 0.6456586136276257 0.12617455287162826 6.171940966294922e-05 7.001255773036307e-06 0.12218046126306298 0.040722661832248284 4.706932754740461e-11 10.327262006166263 -0.3613374947168164 VDIEGPDVNIEGPEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDIEGPDVNIEGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 19770900.0 1540000.0 10163000.0 8067900.0 False True 2018954.9133812166 8646720.015063712 7233111.100761509 1.0 4.282770238084583 3.582601598887593 20.945177262575225 -10.573927534643122 8.90153450367139 0.9995273204621788 3.9326859184860883 0.9590026964590463 0.28584264998858055 0.0026815743123662613 0.00012835486096850267 0.27678453053910823 0.09225531858679734 2.6673036874191773e-11 10.573927534643122 2.933158598023909 VDIEGPDVNIEGPEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDIEGPDVNIEGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 23583800.0 6847800.0 3226000.0 13510000.0 False True 6630420.337296216 4514158.623367762 9971325.708687592 1.0 0.6808254067959388 1.5038753504960662 22.66066890260477 -6.801549187208054 1.4495632651221222 0.8242418269881819 1.5156783824156363 0.8366589329874223 0.13693459235660935 0.21855333945104138 0.9064661011681089 0.07431032040007342 0.17265914851390068 1.5792497353660695e-07 6.801549187208054 0.6914365554274544 VDIEGPDVNIEGPEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDIEGPDVNIEGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 24859800.0 1540000.0 13367000.0 9952800.0 False True 2109379.6169351726 12776401.741242113 7602153.624350253 1.0 6.056947568217053 3.6039760521606903 21.008387324098116 -9.670639443083534 14.566890549268571 0.9999999487883335 4.830461810189263 0.764777400091323 1.0014214279865608 0.0 0.0 0.9696221282817998 0.3232073760939332 2.134816530030502e-10 9.670639443083534 3.8304618614009294 VDIEGPDVNIEGPEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDIEGPDVNIEGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9107050.0 6847800.0 1383300.0 875950.0 False True 5694249.108976625 1375847.8883364487 1059107.0950648035 1.0 0.24162060036458735 0.18599591882890895 22.441074178039045 -13.793728348350943 0.37250842789814964 9.999989943043825 0.18039411934333538 0.9997902350425385 0.0053777693027905055 19.72412724058451 0.19795725747204104 140.99596657468135 0.015431579940236745 1.607946710858691e-14 13.793728348350943 -9.81959582370049 VDIETPNLEGTLTGPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDIETPNLEGTLTGPR 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 17228200.0 2656900.0 7706800.0 6864500.0 False True 3483221.629456204 6556975.480871111 6154227.388933604 1.0 1.8824456719668388 1.7668205022872443 21.731990840567754 -10.294034159963543 5.465492323173779 0.9998857621878556 1.8246330871270693 0.985469264173699 0.04720377785638606 6.57168803828575e-05 8.488530274188182e-06 0.045711097342091576 0.015234953792973996 5.081194742301125e-11 10.294034159963543 0.8247473249392137 VDIETPNLEGTLTGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDIETPNLEGTLTGPR 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 20648200.0 7678300.0 2881900.0 10088000.0 False True 7434556.569388924 4032657.6989099653 7445650.166487085 1.0 0.5424207430896482 1.0014921666133845 22.825815265304417 -10.896119340688795 10.887833675671919 1.016864846837738 0.7719564548523117 0.2475622242602491 0.1874151238543774 0.06991944090906851 0.0006670991633446735 0.1653703243010822 0.060487971126283624 1.2702250094599639e-11 10.896119340688795 -0.24490839198542624 VDIETPNLEGTLTGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDIETPNLEGTLTGPR 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 17263100.0 2656900.0 7752400.0 6853800.0 False True 3639227.7300227657 7409873.3342414405 5235073.598441828 1.0 2.0361114730775824 1.4385122302882318 21.795200902090645 -10.614253425977804 6.4412973137436955 0.9975848570360831 1.7373118516829071 0.6699288370867542 0.2439688692512514 0.00847840319110278 0.0005077411825571559 0.2366909633614648 0.07874061396692925 2.4307851472204345e-11 10.614253425977804 0.739726994646824 VDIETPNLEGTLTGPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDIETPNLEGTLTGPR 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 11154900.0 7678300.0 2368400.0 1108200.0 False True 6384846.656364842 2355640.9591094097 1339919.4962621348 1.0 0.36894244856470426 0.2098593072593863 22.606220540738693 -13.999999999999995 0.19350159445263987 4.424779692792628 0.0996668877914803 0.9994878617190779 0.007721907198847691 12.409849575154789 0.13949796822766908 16.04451013578222 0.10643298580896365 1.0000000000000123e-14 13.999999999999995 -4.325112805001147 VDIK(ub)APDVEGQGLDWSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDIKAPDVEGQGLDWSLK 18 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 11614000.0 4957600.0 4250500.0 2405900.0 True False 4800223.701653046 5947746.816064681 1775722.6145471125 1.0 1.239056174406302 0.36992497119157375 22.19467020968824 -6.83337678447102 1.3127978667446163 1.1274660246249282 0.3448891186886002 0.9124539879701683 0.10846896850029732 0.17668015565149822 0.5943194649765341 0.0648502003286313 0.14923940510419317 1.4676524217366905e-07 6.83337678447102 -0.7825769059363279 down VDINAPDVDVHGPDWHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDINAPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 17674500.0 2542100.0 8028700.0 7103700.0 False True 3332717.7177314153 6830849.25562748 6368677.2675020285 1.0 2.0496333125618715 1.9109561045683745 21.668267695210524 -10.200648515765405 5.2386895987731945 0.9999363494219382 1.9802947085654623 0.9852127252405484 0.05661473309083197 4.209051380246891e-05 6.422476023907727e-06 0.05482050655131488 0.01827232653406008 6.300158625058612e-11 10.200648515765405 0.9803583591435241 VDINAPDVDVHGPDWHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDINAPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 19503700.0 5198000.0 3914700.0 10391000.0 False True 5032992.335241351 5477860.12489081 7669285.376681937 1.0 1.08839031733358 1.5238023159664051 22.262984970076193 -6.9401387700369925 0.6582753594816187 0.9951240591580697 1.641698353445446 0.9981819717229118 0.009762071716841266 0.08770344449640537 0.054322638899856744 0.009512644960387964 0.037452197227242294 1.1477868107851586e-07 6.9401387700369925 0.6465742942873762 VDINAPDVDVHGPDWHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDINAPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 20310000.0 2542100.0 7639900.0 10128000.0 False True 3481983.0676694093 7302343.956229192 7735974.992707523 1.0 2.097179628480175 2.2217152818854546 21.731477756733415 -10.783782473282574 0.4129154117740784 1.8820111588610724e-14 2.2295449145789656 0.999477176084785 0.012551432566348407 2.4039355401730895 0.1994221582994153 2.4097639839001728 0.030682852285164233 1.6451955521904618e-11 10.783782473282574 2.229544914578947 VDINAPDVDVHGPDWHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDINAPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 10701900.0 5198000.0 3128500.0 2375400.0 False True 4322367.310444302 3111646.1495413724 2872085.1573913293 1.0 0.7198939669061865 0.6644704050142615 22.04339024551047 -13.999999999999996 0.22777704337938304 2.750229440334344 0.6369466368321628 0.9995068386871305 0.0032613539954551504 13.223069246993433 0.15113219748812537 10.45384210680531 0.02917307129303554 1.0000000000000082e-14 13.999999999999996 -2.113282803502181 VDINAPDVDVHGPDWHLK(ub)MPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDINAPDVDVHGPDWHLKMPK 21 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 12404500.0 3146000.0 5303000.0 3955500.0 True False 4072559.0169311417 5007883.388288358 3235639.586857367 1.0 1.2296650257169326 0.7944979000686326 21.95750417484402 -6.763317694423559 1.600079538761681 1.1328500306877174 0.7926467493183545 0.7043449669758255 0.09664872725467126 0.27736953969280315 1.4003237970628555 0.0476427696797074 0.11411670646490367 1.724575871393127e-07 6.763317694423559 -0.34020328136936284 VDINAPDVDVQGPDWHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDINAPDVDVQGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 45002000.0 11434000.0 10511000.0 23057000.0 False True 11071033.928655174 14708097.114140898 17017680.00482682 1.0 1.3285206430514054 1.5371355660630697 23.400286626537746 -9.341231189056645 0.08071161943886178 8.980138703229633e-07 2.361536548075635 0.9999789403879658 0.0010146208857298735 0.8080183247780763 0.03029274881689432 0.5221249229963125 0.3522118156265178 4.557942172948311e-10 9.341231189056645 2.361535650061765 VDINAPDVDVQGPDWHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDINAPDVDVQGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 35830900.0 3613900.0 11924000.0 20293000.0 False True 4950056.491975337 11397158.252604978 15500211.347453963 1.0 2.302429936119154 3.1313200915144606 22.239013559208868 -8.434073229760356 0.19407266767620446 8.016390423408512e-12 4.165814146632282 0.9997450746892655 0.014006303894545276 0.13347223863661262 0.048146888092923584 0.4566065493328187 0.4068295864274731 3.6806690579462506e-09 8.434073229760356 4.165814146624265 VDINAPDVDVQGPDWHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDINAPDVDVQGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 16996900.0 11434000.0 0.0 5562900.0 False True 9507877.612085443 0.0 6726076.670056506 1.0 0.0 0.7074214608638846 23.180691901972022 -10.559920262385635 8.619091083063067 1.0001040733661535 0.3537107326424807 0.5267053679098834 0.28880360203512945 0.0005776618622837534 2.9494668800656612e-05 0.2796767190012873 0.09321096175056424 2.7547344334305587e-11 10.559920262385635 -0.6463933407236728 VDINAPDVDVQGPDWHLK(ub)MPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDINAPDVDVQGPDWHLKMPK 21 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 20973500.0 8551900.0 6111200.0 6310400.0 True False 11070603.133151146 5771106.347823454 5161971.950171839 1.0 0.5213000844138075 0.46627739140193813 23.40023048737011 -13.999999999999998 0.3053250913587388 5.502932011523022 0.4534716117702615 0.9996616752798821 0.0044086710979182216 16.943649691613928 0.17565083275519086 48.345407067905036 0.01944028798436489 1.0000000000000041e-14 13.999999999999998 -5.0494603997527605 VDINAPDVEVHGPDWHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDINAPDVEVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 30822900.0 12182100.0 5479000.0 13161800.0 False True 15970851.071624197 4661554.556974727 11799943.19290063 1.0 0.2918789071458455 0.7388424787121006 23.92893785887026 -9.927276645451746 6.172790092377961 1.0000001158037275 0.5153606929301514 0.6105293158357169 0.18247211399179714 2.9079100901254517e-07 5.075372388544919e-08 0.17667790678206013 0.05889262155308745 1.18228819858669e-10 9.927276645451746 -0.4846394228735761 VDINAPDVEVHGPDWHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDINAPDVEVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 42234100.0 10055200.0 7288600.0 24890300.0 False True 9736003.1799382 10198975.989546888 18370783.73700569 1.0 1.0475526559566741 1.8868917149554891 23.214898208583737 -6.918559108748813 0.8353232942345893 0.9805026912901313 2.0178656066618887 0.9937718813930236 0.03214658268856663 0.09902643124268524 0.11005435282982018 0.027488568302869665 0.08124302095121358 1.206259901524553e-07 6.918559108748813 1.0373629153717574 VDINAPDVEVHGPDWHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDINAPDVEVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 81965000.0 5063200.0 71684000.0 5217800.0 False True 7681244.5695022335 58891430.1303517 4186499.542957023 1.0 7.66691251625751 0.5450288042616406 22.872908654851138 -6.661065639857945 1.9690179546289999 5.287820487012476 0.5747551199525007 0.2400056725337658 2.8379409620606237 0.4820487497269148 3.5938106486609995 1.1639639133595923 3.146536045883312 2.182400036008651e-07 6.661065639857945 -4.713065367059975 VDINAPDVEVHGPDWHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDINAPDVEVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 54840100.0 12182100.0 18220800.0 24437200.0 False True 16686151.578873966 17415744.807871956 18665636.659932077 1.0 1.0437244756856767 1.1186304146705883 23.99214792039315 -6.962955658010541 0.39155649921243957 0.9954785846762231 1.1695744776894301 0.9998645917089074 0.0005699868027688239 0.0786617080304267 0.017349984768612634 0.0009663257010203871 0.0062968300519363396 1.0890412800830031e-07 6.962955658010541 0.17409589301320705 VDINAPDVEVHGPDWHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDINAPDVEVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 22899400.0 10055200.0 5030600.0 7813600.0 False True 8361344.320888705 5003499.159304079 9447387.633995485 1.0 0.5984084576931129 1.1298886006157616 22.995303484018013 -6.704571653466526 1.814720184717579 0.7517696562452393 1.128449436108031 0.4394607994341697 0.16937611718956724 0.38596366593115833 2.474192474753702 0.0743763988206052 0.1901935372059658 1.974369104923172e-07 6.704571653466526 0.3766797798627918 VDINAPDVEVQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDINAPDVEVQGK 13 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 11362900.0 4078100.0 2656300.0 4628500.0 False True 3948642.9477390763 3716974.442421502 3416156.9979763534 1.0 0.9413295888274164 0.8651471007102288 21.912925488701323 -6.967544518742767 0.31131996398352335 1.0115551033989076 0.7924953965218228 0.9999563779296323 0.0003645864949233523 0.07710795228621149 0.011868961494803381 0.0011982389338327144 0.006754947065105797 1.0775947857377214e-07 6.967544518742767 -0.21905970687708487 VDINAPDVEVQGK(ub)VK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDINAPDVEVQGKVK 15 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 12551800.0 4766800.0 4968900.0 2816100.0 True False 6170716.567675585 4692376.346985862 2303598.6956260954 1.0 0.7604264910766123 0.37331137646042073 22.557006599801934 -6.9639914131035905 0.3749601585292039 1.0281447814102218 0.09201251547011316 0.9998908197031338 0.002697880392921231 0.07830491446631377 0.016077096053229056 0.005067238975614711 0.032792340681541465 1.086447104701682e-07 6.9639914131035905 -0.9361322659401087 down VDINTPDVDVHGPDWHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDINTPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 18472900.0 3579400.0 7502200.0 7391300.0 False True 4692628.062958912 6382901.00334656 6626519.17835603 1.0 1.360197509308218 1.4121125922299738 22.161964686415423 -12.21817031281789 0.3051577879903165 4.614750734124155e-09 1.4251191056594221 0.9995190176515133 0.004019235135409892 5.937606479736417 0.1683462377900496 3.7436746319095278 0.018346876129230437 6.051035309657871e-13 12.21817031281789 1.4251191010446713 VDINTPDVDVHGPDWHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDINTPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 24857100.0 7888500.0 4543600.0 12425000.0 False True 7638083.88544659 6357883.174560989 9170519.757989902 1.0 0.8323924258903647 1.2006309298937101 22.864779333805842 -6.782995813824689 1.524579873704893 0.905463902988487 1.2038063234568974 0.7777124094954493 0.07097289615084353 0.24595456917223055 1.1294028942300216 0.0366616155575889 0.08627809134149393 1.648178278280352e-07 6.782995813824689 0.2983424204684104 VDINTPDVDVHGPDWHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDINTPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 19868100.0 3579400.0 6693500.0 9595200.0 False True 4902800.909647892 6397759.037555484 7329011.379347071 1.0 1.3049191993429234 1.4948621235924149 22.225174747938315 -9.835832068716051 0.07908306393468911 1.723168781905956e-15 2.2365809194385933 0.9999725536798071 0.0010678663606657221 1.4077497324758423 0.035629712666625 0.6476209559123224 0.36798426691207275 1.4593784579157623e-10 9.835832068716051 2.2365809194385915 VDIRPQLLK(ub)NALQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDIRPQLLKNALQR 14 2 Q5SSJ5;Q5SWC8;Q5SSJ5-2;Q5SSJ5-3;B0QZK4 Q5SSJ5 HP1BP3 Heterochromatin protein 1-binding protein 3 1 15030100.0 1565000.0 3549700.0 9915400.0 True False 1515319.9316376902 4967113.72144095 7318259.2843761 1.0 3.277930698154756 4.8295143036011225 20.531190993423973 -8.164521949303087 0.24892797413635676 4.777615099786398e-16 6.176171365272036 0.9994981445089075 0.03523269583444211 0.09112325547116701 0.05389423706951013 0.4609518436698062 0.5453902631875766 6.846648791591599e-09 8.164521949303087 6.176171365272035 VDIRPQLLK(ub)NALQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDIRPQLLKNALQR 14 2 Q5SSJ5;Q5SWC8;Q5SSJ5-2;Q5SSJ5-3;B0QZK4 Q5SSJ5 HP1BP3 Heterochromatin protein 1-binding protein 3 1 8710800.0 1565000.0 3628700.0 3517100.0 True False 1301366.8412553545 3609151.4728594422 4252509.348766967 1.0 2.773354413562512 3.2677252977068427 20.31159626885825 -9.850669463928627 0.3283771803500411 3.505824080547012e-25 3.4032042171538124 0.9987523315923315 0.0343912378866833 1.2173285787539663 0.1429929976391436 1.3693482349443633 0.1570267045715939 1.4103617986842072e-10 9.850669463928627 3.4032042171538124 VDISAPDVDVHGPDWHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDISAPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 18733000.0 3866400.0 9211400.0 5655200.0 False True 5068887.842270856 7837095.025755977 5070054.152508898 1.0 1.5461172686442728 1.000230091940152 22.27323781153332 -10.679542633913911 2.9033431570201973 0.9679435213041124 1.2731736800550089 0.2503161112280462 0.22285750879664146 165407144.3198288 167427862.86033484 39414405.324129395 0.08593525504391435 2.091497578441468e-11 10.679542633913911 0.30523015875089643 VDISAPDVDVHGPDWHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDISAPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 22812500.0 4851100.0 3987400.0 13974000.0 False True 4697104.48585789 5579589.614016306 10313790.188985966 1.0 1.187878538962762 2.195776189360674 22.16334025564979 -6.938248797627546 0.6756667491574516 0.9882707116594593 2.4541144399594517 0.9979253119529776 0.02391507408317969 0.08857484065561969 0.05831813730319898 0.022981442921065225 0.08743827502493463 1.152792659401173e-07 6.938248797627546 1.4658437282999923 up VDISAPDVDVHGPDWHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDISAPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 20197300.0 3866400.0 8737100.0 7593800.0 False True 5295912.565531255 8351066.032273983 5800300.839220219 1.0 1.5768889551967618 1.0952410500452376 22.336447873056212 -10.380486136097518 4.0929195370429134 0.9990209545041175 1.336065002628472 0.3936165222510568 0.19663193390846898 140673900.62229618 1812.6883252006353 1297970.4738676886 0.06731198606297273 4.1640301356943954e-11 10.380486136097518 0.3370440481243544 VDISAPDVDVHGPDWHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDISAPDVDVHGPDWHLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9741700.0 4851100.0 3043200.0 1847400.0 False True 4033904.590168593 3026805.677572096 2233682.798587499 1.0 0.7503414148537395 0.5537272259813524 21.943745531084065 -6.973811181814105 0.13982349237141248 1.2640065068095818 0.034934422841450534 0.9999989295471462 0.0001888538751380941 0.07508437445631812 0.004233677641998349 0.011133807147809144 0.025626010142651673 1.0621572508705554e-07 6.973811181814105 -1.2290720839681313 VDK(ub)AAAAAAALQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDKAAAAAAALQAK 14 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 30941300.0 9078300.0 10060000.0 11803000.0 True False 11901739.21438225 8559087.213572871 10581738.782370657 1.0 0.7191459213986082 0.8890918034553736 23.50466907578026 -10.315034611855065 5.4551599269843845 1.0000359248864195 0.8041188628336252 0.6391641227252318 0.06938011582106658 3.031940889453504e-05 3.8069773596737574e-06 0.06718931482375085 0.022392336094408313 4.841337821616585e-11 10.315034611855065 -0.19591706205279424 VDK(ub)AAAAAAALQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDKAAAAAAALQAK 14 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 55525000.0 14080000.0 16526000.0 24919000.0 True False 13633038.107002344 23124917.981951497 18391966.346024156 1.0 1.6962409846176425 1.3490732000945176 23.70060376512865 -10.078185249507245 4.380892395799192 0.9999533879221961 1.5226570922147813 0.7513671066521123 0.14173065470531432 99221919.25382648 131177317.20443991 60637.615761235815 0.051868100247755865 8.352466654697118e-11 10.078185249507245 0.5227037042925852 VDK(ub)AAAAAAALQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDKAAAAAAALQAK 14 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 46410300.0 9078300.0 17017000.0 20315000.0 True False 12434792.841832818 16265132.672306206 15517015.400558185 1.0 1.308034068536104 1.2478708409484902 23.56787913730315 -10.042985827393705 4.437388810895535 0.9999845136102499 1.277952454671197 0.9660543539005677 0.024561534909497224 3727198.8216120787 4217819.0549540315 453.4546156621485 0.008408066481323185 9.057621587248597e-11 10.042985827393705 0.277967941060947 VDK(ub)AAAAAAALQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDKAAAAAAALQAK 14 1 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 1 49021200.0 14080000.0 26760000.0 8181200.0 True False 11708143.849760627 26615838.5685559 9891851.094405139 1.0 2.273275671198732 0.84486928255561 23.481009040562927 -6.671639993217406 1.932001013328207 1.81158894219042 0.8506526015719649 0.28620413148259327 0.5406575751727841 0.4573242165100209 3.292658719471065 0.22518834737882343 0.6002664539677957 2.1299038902458967e-07 6.671639993217406 -0.9609363406184552 VDK(ub)AAAAAAALQAK(ub)SDEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDKAAAAAAALQAKSDEK 18 2 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 2 12898920.0 980120.0 5361000.0 6557800.0 True False 1284946.8114955819 4561159.697014334 5879261.76285947 1.0 3.5496875483160935 4.575490370699819 20.293277211716326 -9.165076233390291 0.31991412795961705 1.9459423910309976e-19 4.946785171693269 0.9984568935993967 0.05905047937564441 0.5859079093226977 0.11803261530053459 1.0281873116094686 0.328575215789225 6.83791608160336e-10 9.165076233390291 4.946785171693269 VDK(ub)AAAAAAALQAK(ub)SDEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDKAAAAAAALQAKSDEK 18 2 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 2 8825500.0 1509500.0 1640100.0 5675900.0 True False 1461581.748758527 2295000.483008512 4189211.516649882 1.0 1.5702169823603052 2.866217726246386 20.47909909311762 -6.957469833265306 0.4697434996976642 0.9656835631546938 3.5238571905210545 0.9996645170709999 0.014302189646784815 0.0806177600698901 0.024567799918853408 0.01791068926065493 0.10696791466538058 1.1028848391951139e-07 6.957469833265306 2.5581736273663607 VDK(ub)AAAAAAALQAK(ub)SDEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDKAAAAAAALQAKSDEK 18 2 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 2 8439600.0 1509500.0 2665900.0 4264200.0 True False 1255216.132188472 2651538.2675602804 5155824.504566856 1.0 2.1124157024155816 4.107519312692122 20.259504368551895 -6.9621193985662195 0.40446473596174376 0.8955840342654561 5.397727298203897 0.9998408921223663 0.016216120558919665 0.07895264262675382 0.018397137397123165 0.02566700592482246 0.16688712280904805 1.0911403130666643e-07 6.9621193985662195 4.502143263938441 VDK(ub)AAAAAAALQAK(ub)SDEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDKAAAAAAALQAKSDEK 18 2 P36578;H3BM89;H3BU31 P36578 RPL4 60S ribosomal protein L4 2 12960200.0 5656800.0 3878900.0 3424500.0 True False 7322839.112198374 3663035.805172866 2801276.138337265 1.0 0.5002207134485567 0.3825396264231592 22.803971668512293 -13.99999999999994 0.2031634574282879 3.8122738986298477 0.30845098975307905 0.9994873384908719 0.006060873303873906 12.595245771623588 0.14290660039701375 14.094607795717808 0.07320351035351577 1.000000000000139e-14 13.99999999999994 -3.5038229088767685 VDK(ub)ATFMVGSYGPRPEEYEFLTPVEEAPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDKATFMVGSYGPRPEEYEFLTPVEEAPK 29 2 P52566;H0YGX7 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 81743900.0 29165000.0 19881700.0 32697200.0 True False 28239173.03911387 27820566.491695836 24132822.42502591 1.0 0.9851763878907421 0.8545867257373194 24.75119450530512 -6.92834789773618 0.7602285312934213 1.0021123610121003 0.8288712538355294 0.9962034935030547 0.004025688084940396 0.09350481900176225 0.08194900782928503 0.0036321802741879705 0.011925263571911844 1.1793755017223644e-07 6.92834789773618 -0.17324110717657093 VDK(ub)ATFMVGSYGPRPEEYEFLTPVEEAPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDKATFMVGSYGPRPEEYEFLTPVEEAPK 29 2 P52566;H0YGX7 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 117401200.0 51960200.0 54084000.0 11357000.0 True False 78827422.19944885 44432287.639779255 9112283.972050073 1.0 0.5636653641591481 0.11559789369991327 26.232194260759133 -7.76136473812695 0.44554588211035207 1.0333506557291892 8.150827226304308e-23 0.9970152551322935 0.019726065474046327 0.11434807943862317 0.08184600702525141 0.031039296435323088 0.07715639489963177 1.732348490092273e-08 7.76136473812695 -1.0333506557291892 down VDK(ub)ATFMVGSYGPRPEEYEFLTPVEEAPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDKATFMVGSYGPRPEEYEFLTPVEEAPK 29 2 P52566;H0YGX7 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 8402600.0 2525600.0 2812500.0 3064500.0 True False 3459382.571773682 2688234.4503062326 2340728.2153586275 1.0 0.777085041776091 0.6766317881281624 21.722083138941475 -13.999999999999892 0.10760350238357802 2.080443288333598 0.48582954895494795 0.9997552436250368 0.0021141099962541194 12.027276705806333 0.09914027592382213 2.8362755736100214 0.16958907741568136 1.0000000000002494e-14 13.999999999999892 -1.5946137393786501 VDK(ub)ATFMVGSYGPRPEEYEFLTPVEEAPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDKATFMVGSYGPRPEEYEFLTPVEEAPK 29 2 P52566;H0YGX7 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 66938100.0 29165000.0 27926000.0 9847100.0 True False 24251989.728570215 27775557.095123034 11906083.082153827 1.0 1.145289825947842 0.49093221691941374 24.531599780739395 -6.848452997274879 1.2425093604135466 1.0774427539112363 0.46554086518668497 0.9380250106891874 0.06984566193577547 0.15916923746384715 0.47364377998142854 0.04400350290281447 0.10173268338670738 1.4175781244660413e-07 6.848452997274879 -0.6119018887245513 down VDK(ub)ATFMVGSYGPRPEEYEFLTPVEEAPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDKATFMVGSYGPRPEEYEFLTPVEEAPK 29 2 P52566;H0YGX7 P52566 ARHGDIB Rho GDP-dissociation inhibitor 2 1 137105200.0 51960200.0 78233500.0 6911500.0 True False 67263503.18866672 73879736.95222645 5653677.917978684 1.0 1.098362907816471 0.08405268310395224 26.003320582851583 -6.883089780622304 1.062384887893984 1.0638649601940835 0.007760765620411188 0.9760947788574961 0.07061719631400329 0.12492976476477402 0.2560286855736161 0.051051737452436054 0.12448822511543402 1.3089113070367376e-07 6.883089780622304 -1.0561041945736722 down VDK(ub)GVVPLAGTNGETTTQGLDGLSER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDKGVVPLAGTNGETTTQGLDGLSER 26 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 44525900.0 8836900.0 14120000.0 21569000.0 True False 11585261.476661326 12013351.039328927 19337246.78445757 1.0 1.0369512214748018 1.669124760232018 23.465787270073793 -6.918898115065823 0.8328406397184854 0.9854909397578121 1.7685348704696302 0.9938699401607629 0.024043494354679958 0.09882376789604734 0.10899895814441722 0.020596183879077624 0.06106182519199777 1.2053186734368923e-07 6.918898115065823 0.7830439307118181 VDK(ub)GVVPLAGTNGETTTQGLDGLSER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDKGVVPLAGTNGETTTQGLDGLSER 26 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 58325000.0 14835000.0 12703000.0 30787000.0 True False 14364071.04526845 17775374.145269856 22722961.10979757 1.0 1.237488598409926 1.5819304317129894 23.77596135797162 -6.965810860439465 0.343857081313017 0.9642707734469339 1.8666621840647615 0.9999288917670988 0.002014581959707863 0.07768693220471627 0.013896047463894463 0.004807103453296116 0.029730376397105716 1.0819050290972461e-07 6.965810860439465 0.9023914106178276 VDK(ub)GVVPLAGTNGETTTQGLDGLSER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDKGVVPLAGTNGETTTQGLDGLSER 26 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 425161000.0 60326000.0 99534000.0 265301000.0 True False 91518952.42135233 81771380.03730853 212864141.06444088 1.0 0.8934912154679604 2.3259022905377735 26.44756720250387 -6.8889936948483905 1.028344198041661 0.9211675409711187 2.4466888829028535 0.9802453618701013 0.09158219258919453 0.11996232775434304 0.2266607220574601 0.06794684787169246 0.16878618096035827 1.2912380198622646e-07 6.8889936948483905 1.5255213419317348 up VDK(ub)GVVPLAGTNGETTTQGLDGLSER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDKGVVPLAGTNGETTTQGLDGLSER 26 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 41726900.0 8836900.0 11732000.0 21158000.0 True False 12104140.738243114 11213641.447464097 16160916.16268818 1.0 0.926430193597677 1.3351560025758504 23.528997331596685 -6.8603254161741525 1.1839669487964313 0.9600443916096639 1.3550834303157406 0.9540428824508236 0.038135043542076835 0.1464734855826098 0.3899491777181324 0.025117038276504192 0.05865711425544175 1.3793503322487019e-07 6.8603254161741525 0.3950390387060767 VDK(ub)GVVPLAGTNGETTTQGLDGLSER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDKGVVPLAGTNGETTTQGLDGLSER 26 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 44514000.0 14835000.0 18892000.0 10787000.0 True False 12335959.80193174 18790225.046231586 13042511.826547228 1.0 1.5232073829625437 1.0572758047172661 23.556366633405897 -10.410704169763363 3.449261062213064 0.9973157276779899 1.290241593727715 0.34097142414828385 0.19021577092609254 137558719.26227242 180873259.55698124 3597836.792406224 0.06961183116101832 3.8841485411278294e-11 10.410704169763363 0.29292586604972504 VDK(ub)GVVPLAGTNGETTTQGLDGLSER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDKGVVPLAGTNGETTTQGLDGLSER 26 1 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 279611000.0 60326000.0 108605000.0 110680000.0 True False 78093196.20323841 102561036.27853222 90537375.67270212 1.0 1.3133159002945145 1.1593503669266858 26.21869352459632 -10.131083586712078 4.097324590748005 0.9999365414543232 1.2363331335633834 0.7585432236387588 0.06285616597352972 14629325.996915571 1.166562311923929 8979.052158371878 0.021517337461539155 7.394629402441582e-11 10.131083586712078 0.23639659210906017 VDLHTSGEHSELVQEENLSPGTQTPSNDK(ub)ASMLQEYSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDLHTSGEHSELVQEENLSPGTQTPSNDKASMLQEYSK 38 1 Q9Y2X9-2;Q9Y2X9 Q9Y2X9-2 ZNF281 Zinc finger protein 281 1 45575200.0 3853100.0 9492100.0 32230000.0 True False 4987913.905955949 8963856.290773511 26364470.707726702 1.0 1.7971152790087224 5.285670764334067 22.250005133023766 -6.942813872561315 0.632843535377594 0.961932983522266 6.309786029109479 0.998509732696269 0.07184488491717057 0.0865060427620877 0.048937474643598974 0.07152817120214984 0.29673176134817436 1.1407385740097678e-07 6.942813872561315 5.347853045587213 VDLPLAVLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDLPLAVLSK 10 0 Q9H773;H3BSA6 Q9H773 DCTPP1 dCTP pyrophosphatase 1 0 4942930.0 365830.0 2584500.0 1992600.0 False True 479606.67270275956 2198902.6743020946 1786424.8663688668 1.0 4.584804172782817 3.724770667392318 18.871492205349526 -10.53036473897378 10.108756766400234 0.9999435659164112 4.154787420087567 0.9472046554487723 0.35110720831731446 0.00044656879322626283 2.0747361355853233e-05 0.3399635838064766 0.11331936421219481 2.94873171616598e-11 10.53036473897378 3.154843854171156 VDLPLAVLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDLPLAVLSK 10 0 Q9H773;H3BSA6 Q9H773 DCTPP1 dCTP pyrophosphatase 1 0 3827300.0 1473200.0 1054300.0 1299800.0 False True 1426434.0723889107 1475287.4881018691 959343.3868358358 1.0 1.0342486320669146 0.6725466009299553 20.443981638616368 -6.883698808936034 1.0589842263386406 1.0224705949230388 0.6450261745364878 0.9765474151810342 0.024967740397560508 0.12440282047263734 0.2529301371455953 0.018097600266771808 0.04420520751039244 1.307077055409776e-07 6.883698808936034 -0.377444420386551 VDLPLAVLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDLPLAVLSK 10 0 Q9H773;H3BSA6 Q9H773 DCTPP1 dCTP pyrophosphatase 1 0 5339230.0 365830.0 2660700.0 2312700.0 False True 501087.2371840217 2543141.4762417027 1766487.8915516068 1.0 5.07524695806161 3.5253100866803226 18.934702266872417 -9.382575600041116 9.327229284264575 1.0000000005748015 4.300278110212583 0.8580597327479865 0.6327590780685801 0.0 0.0 0.6126663428803364 0.20422211429344542 4.144044400872819e-10 9.382575600041116 3.300278109637781 VDLPLAVLSK(ub)MDINR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDLPLAVLSKMDINR 15 1 Q9H773;H3BSA6 Q9H773 DCTPP1 dCTP pyrophosphatase 1 1 8820090.0 907690.0 1429600.0 6482800.0 True False 878875.8777943853 2000446.7352655139 4784760.2001687605 1.0 2.276142497261169 5.4441819613669775 19.745299904726053 -6.955611868661258 0.493405279613072 0.9327620781452542 6.9226800889918065 0.9995712555121424 0.03868582376587063 0.0813075101770687 0.027219161314335927 0.0459516606733379 0.2612955308786723 1.1076132217346826e-07 6.955611868661258 5.989918010846552 VDLPLAVLSK(ub)MDINR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDLPLAVLSKMDINR 15 1 Q9H773;H3BSA6 Q9H773 DCTPP1 dCTP pyrophosphatase 1 1 2600990.0 907690.0 1693300.0 0.0 True False 754784.4524850294 1684177.8568062654 0.0 1.0 2.231336179834295 0.0 19.52570518016033 -6.760161287756637 1.6332484050029326 1.7178367640225989 3.554645699732129e-15 0.6780239109321212 0.5178188084330072 0.2856704045734546 1.5054975064845828 0.2510694115468031 0.5981750349039063 1.7371555662163835e-07 6.760161287756637 -1.7178367640225953 VDLSEK(ub)YKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDLSEKYKK 9 2 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4 P43243 MATR3 Matrin-3 1 5522300.0 1377900.0 1287200.0 2857200.0 True False 1783718.712469621 1215566.1884602623 2337218.9173477106 1.0 0.6814786322319107 1.3103068892021372 20.76645669348307 -6.768974845817581 1.5781858219621596 0.8170699309699855 1.313725296531961 0.7267191440051234 0.13420644716914737 0.2680763992170361 1.3175236992447337 0.06703327441098109 0.15973001894947764 1.702257099667438e-07 6.768974845817581 0.49665536556197554 VDLSEKYK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDLSEKYK 8 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4 P43243 MATR3 Matrin-3 1 9588500.0 2893000.0 3340500.0 3355000.0 True False 3792751.015851854 2842110.4211670132 3007856.7834324753 1.0 0.7493532819023381 0.793054110554871 21.85481323492256 -10.325559054202484 5.685476853655021 1.0000334911929742 0.7712036962286107 0.9733670492986436 0.017840788589256373 7.57489706792948e-06 8.98552630843292e-07 0.017276794716179555 0.005758089757448958 4.725425774532701e-11 10.325559054202484 -0.2288297949643635 VDLSEKYK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDLSEKYK 8 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4 P43243 MATR3 Matrin-3 1 21564100.0 4368000.0 4770100.0 12426000.0 True False 6626575.343574368 3918838.386038591 9969995.653490713 1.0 0.5913821518438774 1.5045472414583467 22.659832038255736 -6.785045660317983 1.5159901616984597 0.7701470812122623 1.5129883830705 0.7849110462160964 0.17321283191610534 0.24281033554655093 1.1024151693413244 0.08996031748191013 0.21141124563711394 1.6404172959609534e-07 6.785045660317983 0.7428413018582377 VDLSEKYK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDLSEKYK 8 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4 P43243 MATR3 Matrin-3 1 19908200.0 4368000.0 5487200.0 10053000.0 True False 5654462.106152334 5181832.496363546 8223457.152490732 1.0 0.9164147533547808 1.4543305796572947 22.430958360348185 -6.867206026779519 1.1486874873387705 0.9534334064870982 1.4842162715428917 0.9618188342979868 0.04618299072652688 0.139566616679806 0.3459228303656244 0.03125076614476061 0.07365381772931709 1.3576692233981083e-07 6.867206026779519 0.5307828650557935 VDMVWIVGGSSVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDMVWIVGGSSVYK 14 0 P00374;P00374-2;B4DM58 P00374 DHFR Dihydrofolate reductase 0 3587250.0 1133500.0 1661600.0 792150.0 False True 1486029.4768296147 1413695.7568660728 710185.9168393553 1.0 0.9513241688059492 0.4779083644790875 20.503031302733746 -6.926655232603831 0.7737691615520657 1.008162527804755 0.38851401720374285 0.9958386498411697 0.015190681053135119 0.09441275376989901 0.08646867684829579 0.01357324980456919 0.04365050996087442 1.1839810935579193e-07 6.926655232603831 -0.6196485106010121 down VDMVWIVGGSSVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDMVWIVGGSSVYK 14 0 P00374;P00374-2;B4DM58 P00374 DHFR Dihydrofolate reductase 0 7474200.0 2640800.0 2654700.0 2178700.0 False True 2556969.249500835 3714735.5540776136 1608033.1104010118 1.0 1.452788513120678 0.6288824594644336 21.286003379939164 -6.757509847718439 1.621946118638603 1.263818994151057 0.6262479653760304 0.6806805252044688 0.19038154391405085 0.28712083412420714 1.488114487237192 0.0926405051877429 0.22317150823483756 1.7477936303818448e-07 6.757509847718439 -0.6375710287750265 VDMVWIVGGSSVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDMVWIVGGSSVYK 14 0 P00374;P00374-2;B4DM58 P00374 DHFR Dihydrofolate reductase 0 4644500.0 1133500.0 1158600.0 2352400.0 False True 1552585.5816857244 1107409.2210221528 1796811.5691987714 1.0 0.7132677477397285 1.1573027538023881 20.566241364256637 -6.732361672535275 1.7145929157553021 0.8279021842015207 1.157156109404063 0.5701994516285432 0.12051454088427924 0.331824627693879 1.91215310138859 0.05567574804547137 0.13778912734377294 1.8519886785921983e-07 6.732361672535275 0.32925392520254226 VDMVWIVGGSSVYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDMVWIVGGSSVYK 14 0 P00374;P00374-2;B4DM58 P00374 DHFR Dihydrofolate reductase 0 6724800.0 2640800.0 2436800.0 1647200.0 False True 2195942.2072761245 2423672.4747330686 1991621.9042077102 1.0 1.1037050368185344 0.9069555189606489 21.06640865537344 -6.763488940510827 1.5993244508137705 1.0599754299826702 0.9061096219840078 0.7050608967992273 0.043643203969059574 0.2770904424165631 1.3976107823119575 0.021523096487083188 0.051547061435776684 1.7238959901946476e-07 6.763488940510827 -0.15386580799866245 VDNAASEK(ub)NKEELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDNAASEKNKEELK 14 2 E7EWR4;P33240-2;P33240;A0A0A0MT56;E9PID8;Q9H0L4 E7EWR4;Q9H0L4 CSTF2;CSTF2T Cleavage stimulation factor subunit 2;Cleavage stimulation factor subunit 2 tau variant 1 3956430.0 1421900.0 1905700.0 628830.0 True False 1864124.6696991888 1621376.9883604182 563764.7037632917 1.0 0.8697792667601237 0.3024286481087478 20.8300669176974 -6.942916810128782 0.6318476986918549 1.006189812674333 0.13534412130493256 0.9985215049297353 0.011644852889717434 0.08646086975365315 0.048737083849716575 0.011603636661968337 0.0482384410739797 1.1404682253322004e-07 6.942916810128782 -0.8708456913694004 down VDNAASEK(ub)NKEELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDNAASEKNKEELK 14 2 E7EWR4;P33240-2;P33240;A0A0A0MT56;E9PID8;Q9H0L4 E7EWR4;Q9H0L4 CSTF2;CSTF2T Cleavage stimulation factor subunit 2;Cleavage stimulation factor subunit 2 tau variant 1 5189100.0 2108200.0 1832100.0 1248800.0 True False 2041276.344970335 2563667.0842752834 921701.8168030396 1.0 1.2559137769817932 0.4515321108159093 20.96104007483572 -6.8211144617973805 1.3669025160239308 1.1377842320494238 0.43352649314434194 0.8869641484438503 0.11281430584691036 0.19203127887118007 0.7046859436556406 0.06484938663030478 0.14943532453942096 1.5096822128586593e-07 6.8211144617973805 -0.7042577389050819 down VDNAASEK(ub)NKEELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDNAASEKNKEELK 14 2 E7EWR4;P33240-2;P33240;A0A0A0MT56;E9PID8;Q9H0L4 E7EWR4;Q9H0L4 CSTF2;CSTF2T Cleavage stimulation factor subunit 2;Cleavage stimulation factor subunit 2 tau variant 1 3724440.0 1421900.0 1650900.0 651640.0 True False 1947614.8554026757 1577957.7792037542 497736.052947071 1.0 0.8102001146820716 0.2555618486716474 20.893276979220293 -6.952039528907695 0.5359840604901894 1.0083884629795319 0.031935804817001895 0.9993517800506132 0.008041522475568042 0.08267693623430737 0.03265168801512587 0.008894367128029972 0.045903626523626576 1.1167615969952856e-07 6.952039528907695 -0.97645265816253 down VDNAASEK(ub)NKEELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDNAASEKNKEELK 14 2 E7EWR4;P33240-2;P33240;A0A0A0MT56;E9PID8;Q9H0L4 E7EWR4;Q9H0L4 CSTF2;CSTF2T Cleavage stimulation factor subunit 2;Cleavage stimulation factor subunit 2 tau variant 1 4948190.0 2108200.0 2340000.0 499990.0 True False 1753061.7090955493 2327393.9555463656 604535.5973074397 1.0 1.327616674000101 0.3448455888180545 20.741445350269995 -6.816820637739856 1.3855102248887918 1.1771687802733846 0.32480672421447093 0.8769389209770457 0.1433282328523243 0.1976374420930964 0.7463170258730784 0.0813087043214895 0.187586636807202 1.5246823128029176e-07 6.816820637739856 -0.8523620560589136 down VDNAASEK(ub)NKEELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDNAASEKNKEELK 14 2 E7EWR4;P33240-2;P33240;A0A0A0MT56;E9PID8;Q9H0L4 E7EWR4;Q9H0L4 CSTF2;CSTF2T Cleavage stimulation factor subunit 2;Cleavage stimulation factor subunit 2 tau variant 1 8228400.0 3108000.0 2382500.0 2737900.0 True False 4023367.2678391626 2249911.780614182 2239630.2932263403 1.0 0.5592111360548365 0.5566556926405535 21.939972007836044 VDNDENEHQLSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDNDENEHQLSLR 13 0 P06748-2;P06748;P06748-3;E5RGW4 P06748-2 NPM1 Nucleophosmin 0 185913460.0 47940600.0 14982560.0 122990300.0 False True 46418751.89435766 20965174.34101825 90775450.80008885 1.0 0.4516531247701778 1.9555771556865769 25.468204396285827 -6.808053365543888 1.4228350061598558 0.7004643780865784 1.9806985106238921 0.8546503000716884 0.2369194289258013 0.2094680668642308 0.8361647181410825 0.13094727316655194 0.3031650574651231 1.555774448308357e-07 6.808053365543888 1.2802341325373137 VDNDENEHQLSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDNDENEHQLSLR 13 0 P06748-2;P06748;P06748-3;E5RGW4 P06748-2 NPM1 Nucleophosmin 0 663049000.0 3680900.0 656969000.0 2399100.0 False True 5584194.4098358285 539727749.0277743 1924916.833437117 1.0 96.65275049828395 0.34470806210590155 22.412917738168254 -13.69316269077359 5.378221669797647e-10 9.014197845930484 78.48347472157313 0.0 46.583994017525555 844653568.8229694 0.24997069012265338 943582832.9926493 943582894.5592995 2.02692327287243e-14 13.69316269077359 69.46927687564265 VDNIIK(ub)AAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDNIIKAAPR 10 1 P78371;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 1 5509900.0 1336000.0 2358200.0 1815700.0 True False 1751508.9378424035 2006365.7521916055 1627828.7814242486 1.0 1.1455070019015416 0.9293865113982744 20.74016691946701 -6.725314308830006 1.7400200277299172 1.0880196892319998 0.9296149434262089 0.537482158187861 0.061193782456291645 0.34512495392018455 2.0447785225484436 0.027893225496901795 0.06959312914035473 1.882286342831405e-07 6.725314308830006 -0.1584047458057909 VDNIIK(ub)AAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDNIIKAAPR 10 1 P78371;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 1 9313200.0 2920800.0 2281000.0 4111400.0 True False 2828080.8027650905 3191815.1952578602 3034501.000643834 1.0 1.1286152758213757 1.072989497922733 21.431391910151515 -10.083769508453855 5.187458324879674 0.9999982194124826 1.1008023868722372 0.8140755288563082 0.022709128733481566 4.6768126593119017e-07 8.255483742675805e-08 0.021988407606337582 0.00732933978254606 8.245756229546517e-11 10.083769508453855 0.10080416745975462 VDNIIK(ub)AAPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDNIIKAAPR 10 1 P78371;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 1 25800500.0 3778700.0 7920800.0 14101000.0 True False 5732564.159973548 6507271.354507139 11313931.169312133 1.0 1.1351414782136806 1.9736248655199244 22.450749166144227 -6.93512990553193 0.7034119469684347 0.9893461103155599 2.1706396186678405 0.9974538853514835 0.021731018916825863 0.0900601873848602 0.06526364329248432 0.020441518279199534 0.07384592639150746 1.1611012549784806e-07 6.93512990553193 1.1812935083522806 VDNIIK(ub)AAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDNIIKAAPR 10 1 P78371;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 1 5345900.0 1336000.0 2041700.0 1968200.0 True False 1829955.3040424588 1951490.9430009748 1503351.6963513964 1.0 1.066414539573747 0.8215237241207043 20.803376980989903 -6.834486179946687 1.3078902800751282 1.0353916595929926 0.8143161060026826 0.9145244718305914 0.030232135861748038 0.1753424732881883 0.5850141058522432 0.018140738888661034 0.04174795301648282 1.4639081210722295e-07 6.834486179946687 -0.22107555359031006 VDNIIK(ub)AAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDNIIKAAPR 10 1 P78371;P78371-2 P78371 CCT2 T-complex protein 1 subunit beta 1 8811500.0 2920800.0 3637300.0 2253400.0 True False 2428774.6133793225 3617705.142952474 2724575.5214555934 1.0 1.4895186745710052 1.1217901844192544 21.21179718558579 -10.715064115247484 11.492765228905185 0.999837621727789 1.305654429495122 0.47948717830859944 0.15012452745930974 0.0006249287289833629 1.5493551477744806e-05 0.1454319858476775 0.04845248289226373 1.9272403721247795e-11 10.715064115247484 0.305816807767333 VDNIQAGELTEGIWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDNIQAGELTEGIWR 15 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 18034500.0 1529900.0 7684400.0 8820200.0 False True 2005713.7155726736 6537917.473556597 7907570.313332675 1.0 3.2596463906065893 3.9425219321865668 20.93568426769782 -9.579309199643403 0.34350949357177646 1.0743008205532447e-22 4.115604839724297 0.9985297196800833 0.048216180302420975 0.934376911217405 0.14192105789951745 1.2788509368040872 0.20455455054218452 2.634455095313425e-10 9.579309199643403 4.115604839724297 VDNIQAGELTEGIWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDNIQAGELTEGIWR 15 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 16346000.0 5790700.0 2112000.0 8443300.0 False True 5606877.398168921 2955332.613934499 6231746.4364294605 1.0 0.5270906431625639 1.1114468881492947 22.418766093027543 -6.691368464658371 1.8613239311938972 0.7039037987483336 1.109475034511244 0.3769671991682262 0.19995105035385982 0.4137200872415118 2.7799992455022062 0.08589961346058557 0.2233223818561023 2.035314540904356e-07 6.691368464658371 0.40557123576291043 VDNIQAGELTEGIWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDNIQAGELTEGIWR 15 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 12790600.0 1529900.0 4893500.0 6367200.0 False True 2095545.3739929313 4677288.989359489 4863398.496600246 1.0 2.2320151342975723 2.320827101602359 20.99889432922071 -10.756252130065478 0.49097709344639995 5.1321172558954595e-11 2.318003515987247 0.999691611029593 0.010585809968998047 2.33492085901593 0.23626598514273206 2.785652465557851 0.01835460521562695 1.7528625803910543e-11 10.756252130065478 2.318003515935926 VDNLTYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDNLTYR 7 0 J3QL05;J3KP15;Q01130-2;Q01130;Q9BRL6-2;Q9BRL6 J3QL05 SRSF2;SRSF8 Serine/arginine-rich splicing factor 2;Serine/arginine-rich splicing factor 8 0 14390100.0 4090600.0 953300.0 9346200.0 False True 3960746.142081237 1333957.6613938273 6898149.840010077 1.0 0.3367945365700408 1.7416288730853462 21.917340806215023 -6.778351088602443 1.5425193439834808 0.6236708416840152 1.7521456434703278 0.7614404974744847 0.28026786022473804 0.25314249661505894 1.1896170569884037 0.1431303968544414 0.3381645897455524 1.665899935577712e-07 6.778351088602443 1.1284748017863127 VDPLVSLMMVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDPLVSLMMVEK 12 0 P62195;J3QQM1;J3QRW1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 0 4862500.0 1119500.0 1894300.0 1848700.0 False True 1467675.3412534222 1611677.823923567 1657414.2579826005 1.0 1.0981160333096311 1.1292785341526128 20.485101439845558 -13.999999941592792 0.16050292007178182 0.5162751554789993 1.1597434548374763 0.99953504278757 0.001187810876699317 12.012848371145418 0.1266188172583209 1.8089323879280008 0.027783098162533593 1.0000001344875753e-14 13.999999941592792 0.643468299358477 VDPLVSLMMVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDPLVSLMMVEK 12 0 P62195;J3QQM1;J3QRW1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 0 5374750.0 1905000.0 1616950.0 1852800.0 False True 1844526.8177442807 2262606.567282857 1367496.0971914425 1.0 1.2266596210565572 0.7413804364545855 20.814819333984676 -6.77968776591044 1.5369631443346472 1.1283929317448602 0.7375658437180329 0.7663143750549923 0.09583976948882983 0.25106574116014757 1.1714115954671087 0.04911310574687317 0.11592260217142317 1.6607804890850396e-07 6.77968776591044 -0.3908270880268273 VDPLVSLMMVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDPLVSLMMVEK 12 0 P62195;J3QQM1;J3QRW1;J3QSE0;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 0 4729900.0 1119500.0 1341200.0 2269200.0 False True 1533409.4033499504 1281941.3492447007 1733261.6956409868 1.0 0.8360072309744012 1.1303319856096035 20.54831150136845 -6.755468645084723 1.6293589432419602 0.9042094970881326 1.1311789913817873 0.6722577193660375 0.0689385391497638 0.2906014426283065 1.5193918697891078 0.03339951832493504 0.0806329003650387 1.7560276701854114e-07 6.755468645084723 0.22696949429365476 VDPSLMEDSDDGPSLPTK(ub)QNEEFRPFIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDPSLMEDSDDGPSLPTKQNEEFRPFIR 28 2 O15258;Q5T092;A0A0A0MR06;Q5T091 O15258 RER1 Protein RER1 1 51441900.0 6161900.0 23011000.0 22269000.0 True False 9348052.795231432 18904507.264236405 17867522.38915058 1.0 2.022293591867587 1.9113630165059663 23.156234451412764 -10.195030598526166 5.62892107529475 0.9999715398929488 1.9668283041868253 0.9902231675513207 0.04528721775172835 1.617543948115768e-05 2.3131396828416912e-06 0.04385044446008785 0.01461638667901741 6.382185184674577e-11 10.195030598526166 0.9668567642938765 VDPSLMEDSDDGPSLPTK(ub)QNEEFRPFIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDPSLMEDSDDGPSLPTKQNEEFRPFIR 28 2 O15258;Q5T092;A0A0A0MR06;Q5T091 O15258 RER1 Protein RER1 1 29933900.0 6161900.0 10629000.0 13143000.0 True False 7976701.019207888 10037486.806358092 10751108.858568165 1.0 1.2583506367090647 1.3478139437192778 22.927360773505214 -13.267882966592735 0.1562228783990316 7.768242165231509e-07 1.4427404243475253 0.9995472208598318 0.003137924224613167 9.168735798769958 0.11881673944341907 2.8656057337036227 0.08293931449642185 5.396560290937777e-14 13.267882966592735 1.4427396475233087 VDQICHK(ub)NSIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDQICHKNSIK 11 1 Q9UBE0;M0QX65;B3KNJ4;Q9UBE0-2;Q9UBE0-3;A0A590UK93;A0A590UKC5;M0R054;M0QYM8;M0QYP2;M0R286 Q9UBE0 SAE1 SUMO-activating enzyme subunit 1;SUMO-activating enzyme subunit 1, N-terminally processed 1 9812800.0 2927200.0 4173300.0 2712300.0 True False 3837587.547045121 3550659.907395988 2431657.2142187483 1.0 0.9252322882197013 0.6336421474191734 21.871768232444683 -6.945457618313341 0.6066753354528993 1.0032420750166846 0.5405338701138046 0.9987947988800459 0.00548704333225741 0.08536282433029066 0.04391917412706945 0.00559514708071554 0.024559212856326552 1.1338154788566683e-07 6.945457618313341 -0.46270820490288 VDQICHK(ub)NSIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDQICHKNSIK 11 1 Q9UBE0;M0QX65;B3KNJ4;Q9UBE0-2;Q9UBE0-3;A0A590UK93;A0A590UKC5;M0R054;M0QYM8;M0QYP2;M0R286 Q9UBE0 SAE1 SUMO-activating enzyme subunit 1;SUMO-activating enzyme subunit 1, N-terminally processed 1 9448200.0 2927200.0 3356900.0 3164100.0 True False 4009464.944605601 3208581.0582161755 2416804.746685017 1.0 0.8002516800983763 0.6027748789614996 21.934978293967575 -6.971266773805413 0.22590612382145867 1.0845409955265704 0.31287066774434785 0.9999906438748054 0.0004960004157690801 0.0758938631838261 0.00754323521275736 0.005230757061661227 0.019772684809253347 1.0683983931870265e-07 6.971266773805413 -0.7716703277822226 VDQICHK(ub)NSIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDQICHKNSIK 11 1 Q9UBE0;M0QX65;B3KNJ4;Q9UBE0-2;Q9UBE0-3;A0A590UK93;A0A590UKC5;M0R054;M0QYM8;M0QYP2;M0R286 Q9UBE0 SAE1 SUMO-activating enzyme subunit 1;SUMO-activating enzyme subunit 1, N-terminally processed 1 7453900.0 3597900.0 2399600.0 1456400.0 True False 2991813.263995295 2386672.8785166903 1760926.506367238 1.0 0.7977345736242594 0.5885816897595008 21.51258870059409 -6.970705182152756 0.24075028725179973 1.0744055742554168 0.30585565097057354 0.9999873706334212 0.000596896105547761 0.07607457102284589 0.008207167886339314 0.004973102757753433 0.020363127446838734 1.069780846217685e-07 6.970705182152756 -0.7685499232848433 VDQIIMAKPAGGPKPPSGKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDQIIMAKPAGGPKPPSGKK 20 3 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 1 14179600.0 2715000.0 4706700.0 6757900.0 True False 4118853.4930870943 3866752.6113850516 5422198.10290721 1.0 0.9387934331422184 1.3164338357767744 21.97381138002761 -6.865345540957795 1.1583643383467261 0.9661864392945059 1.3366851756489384 0.9598167991502393 0.03317414033763052 0.14139963178479595 0.3575314103232584 0.022282319387921308 0.05237072602809652 1.3634978549329247e-07 6.865345540957795 0.37049873635443253 VDQIIMAKPAGGPKPPSGKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDQIIMAKPAGGPKPPSGKK 20 3 P50990;P50990-2;P50990-3;H7C2U0 P50990 CCT8 T-complex protein 1 subunit theta 1 13782300.0 2715000.0 4143500.0 6923800.0 True False 3514621.0206510075 3912910.582570773 5663739.444187345 1.0 1.113323615712624 1.6114794200878761 21.74493770212006 -6.9427136770155755 0.633821125365534 0.994562863514086 1.7572641669508215 0.9984981097242797 0.010293269890669985 0.08655027616665874 0.04913484909712095 0.010239160775136192 0.04238935545472211 1.14100178276419e-07 6.9427136770155755 0.7627013034367356 VDQSLHTNTSLDAASEYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDQSLHTNTSLDAASEYAK 19 0 E9PCB6;Q9BYT8;H0YAK4;H0YAF7 E9PCB6 NLN Neurolysin, mitochondrial 0 4141570.0 0.0 527970.0 3613600.0 False True 0.0 738791.1743271782 2667089.7543237256 0.0 VDSHSK(ub)ILYAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDSHSKILYAR 11 1 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07;Q13098-6 Q13098-7 GPS1 COP9 signalosome complex subunit 1 1 6229400.0 1147600.0 2147500.0 2934300.0 True False 1111170.0661644805 3005007.9490645565 2165718.802886901 1.0 2.704363661844488 1.9490435072306216 20.083648209485293 -10.05484346012984 4.777030040899801 0.9999594744705836 2.326703584024129 0.8044438996965814 0.3083581619567415 0.00013309486065915389 2.633214281763946e-05 0.2985755655134359 0.09952216881538492 8.813665011179059e-11 10.05484346012984 1.326744109553545 VDSHSK(ub)ILYAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDSHSKILYAR 11 1 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07;Q13098-6 Q13098-7 GPS1 COP9 signalosome complex subunit 1 1 6090500.0 1147600.0 3257600.0 1685300.0 True False 954280.2473000918 3240050.6622170242 2037688.4380532133 1.0 3.395282121142059 2.1353144883993633 19.86405348491957 -10.236007900478095 10.820461649954922 0.9999999904516411 2.7652983047707114 0.7235519408161759 0.5143796321070059 1.1890572227940013e-07 8.916349421984422e-09 0.4980459409053859 0.16601531239822764 5.8075385262809795e-11 10.236007900478095 1.7652983143190704 VDSLLENLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDSLLENLEK 10 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 28544400.0 941400.0 10088000.0 17515000.0 False True 1234184.516530569 8582909.722716011 15702715.81574361 1.0 6.954316480037793 12.723150878513454 20.23512666979485 -7.535736401235184 0.3282390192375992 2.5682587484389215e-20 16.539857639927156 0.9993228017371035 0.12455029638238396 0.14177819935769204 0.04318557797717864 0.40652978310099724 1.1967988450345408 2.912484339074719e-08 7.535736401235184 16.539857639927156 VDSLLENLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDSLLENLEK 10 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 16915500.0 5075900.0 2223100.0 9616500.0 False True 4914768.3329071915 3110795.4233133513 7097650.161183888 1.0 0.6329485364518186 1.4441474511954209 22.228691983277013 -6.78364017992278 1.5212823440922105 0.7931575877550974 1.4513739759008708 0.7802320588724926 0.15548436291752474 0.24493363861353917 1.11975695386188 0.08047560837081413 0.1893516254753033 1.645734676603076e-07 6.78364017992278 0.6582163881457734 VDSLLENLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDSLLENLEK 10 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V2D6;G3V5V7;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;P07910;G3V2Q1;G3V576 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 28127700.0 941400.0 9215300.0 17971000.0 False True 1289461.0203784222 8808137.575078055 13726619.924362836 1.0 6.830867653907912 10.645238365045298 20.298336731317743 -8.214237901001814 0.3549184237595154 1.7292544231981117e-12 12.168201765530194 0.9978861102524648 0.1823557368638302 0.10385418770043302 0.09090082419409308 0.8257246374328199 1.0144065150313608 6.1060745026929146e-09 8.214237901001814 12.168201765528465 VDSTAK(ub)VAEIEHAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDSTAKVAEIEHAEK 15 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 17890100.0 5289000.0 8358400.0 4242700.0 True False 6933930.218748858 7111359.3007880235 3803706.1028521517 1.0 1.025588530089243 0.5485642316629029 22.725241887034297 -6.894228544463988 0.9970146538988538 1.0230937411378505 0.5039657851226809 0.9834702422160442 0.028167899421981984 0.1157799418346337 0.2023347838204068 0.021397856773907112 0.054225720567689824 1.2757672684386755e-07 6.894228544463988 -0.5191279560151696 VDSTAK(ub)VAEIEHAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDSTAKVAEIEHAEK 15 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 26281500.0 8095300.0 9257500.0 8928700.0 True False 7838319.132643184 12954068.027224747 6590005.614741593 1.0 1.652658919343651 0.8407421927103084 22.90211288195668 -6.692737000490525 1.8566150503224477 1.408133121614468 0.8434513522778275 0.383193036465611 0.2758796074758057 0.41087199159294213 2.7479853559160126 0.11877645482909578 0.30824789731130814 2.0289110129645958e-07 6.692737000490525 -0.5646817693366404 VDSTAK(ub)VAEIEHAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDSTAKVAEIEHAEK 15 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 37167400.0 15518000.0 5883600.0 15765800.0 True False 23541940.51776262 4833625.611223381 12649682.719604379 1.0 0.20531976145196545 0.5373254048475771 24.488729908120938 -10.5671315853356 6.365432937170319 1.0011041625063053 0.371322583171702 0.8270145333724708 0.1355407363406134 0.002127063578011415 0.00014464689828836742 0.13143268712063122 0.043745584548323835 2.7093706049839788e-11 10.5671315853356 -0.6297815793346033 VDSTAK(ub)VAEIEHAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDSTAKVAEIEHAEK 15 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 17581200.0 5289000.0 6022500.0 6269700.0 True False 7244486.2298507225 5756406.036255752 4788925.988524722 1.0 0.7945913421074121 0.6610442530475209 22.78845194855719 -9.044309410560622 0.06884138854714107 1.7333543533529645 3.219396054451597e-11 0.9999913495602689 0.00040998947029737763 0.5166991528081932 0.022411539852997583 0.3110174118639381 0.24396940559297148 9.030059032273016e-10 9.044309410560622 -1.7333543533207705 VDSTAK(ub)VAEIEHAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDSTAKVAEIEHAEK 15 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 25038800.0 8095300.0 12316400.0 4627100.0 True False 6731600.632597099 12250049.108586019 5594605.216706835 1.0 1.8197825119432054 0.8310958302570003 22.682518157390955 -6.686528616308147 1.8784803787097444 1.5156008236915497 0.834621574613438 0.35437388746477316 0.34695628398005696 0.4241592749463352 2.899022213062876 0.14790039755868536 0.38687516165167335 2.0581232732762187e-07 6.686528616308147 -0.6809792490781117 VDSTAK(ub)VAEIEHAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDSTAKVAEIEHAEK 15 1 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 39598700.0 15518000.0 9891500.0 14189200.0 True False 20088356.905510984 9341029.329672694 11606911.193486664 1.0 0.4649971808849186 0.577792959776738 24.259856230213387 -9.979130913483864 5.987058363161187 1.0000003698063398 0.5213950703308784 0.9600084987136319 0.046048683904401665 2.272973880739427e-07 3.872893754471861e-08 0.04458648101610177 0.01486214882300261 1.0492261028530636e-10 9.979130913483864 -0.4786052994754614 VDTCHTPFGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDTCHTPFGKR 11 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 5391700.0 1430000.0 1472600.0 2489100.0 True False 1874743.8481396975 1252893.8201498406 2231551.809133166 1.0 0.6683013369496229 1.1903235801240408 20.83826205865871 -6.735025765059486 1.704825052485947 0.8015088007080747 1.1903130163052502 0.5823990236907137 0.1393924118806545 0.3269151669931597 1.8635804341446598 0.06473483871556626 0.1597342112922759 1.8406627986232558e-07 6.735025765059486 0.3888042155971755 VDTCHTPFGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDTCHTPFGKR 11 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 3580840.0 994740.0 1062500.0 1523600.0 True False 963162.5231931476 1486761.7908643025 1124523.452979752 1.0 1.5436250425683922 1.1675324007122379 19.87741973213319 -10.068475760953914 4.637622146656572 0.9999848942868 1.3555787214004145 0.5437638229476216 0.15353917813485113 106542951.9501551 1.6479010193577848 19360.289271817575 0.052560544572100985 8.541305172188574e-11 10.068475760953914 0.3555938271136144 VDTCHTPFGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDTCHTPFGKR 11 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 23479800.0 3916000.0 3723800.0 15840000.0 True False 5940858.297948083 3059258.7958178003 12709217.057081368 1.0 0.5149523254702842 2.139289715338104 22.50223994693958 -6.826683306158306 1.34277648381526 0.7401760392051816 2.180077037411174 0.8990544341025528 0.2163117774927877 0.18494102416373304 0.6533297676881741 0.12652855425841075 0.2912322485190871 1.490447537515696e-07 6.826683306158306 1.4399009982059923 up VDTCHTPFGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDTCHTPFGKR 11 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 6429200.0 1430000.0 1505100.0 3494100.0 True False 1958709.644296942 1438599.7052998785 2668865.543248353 1.0 0.7344629713181652 1.362563129772261 20.9014721201816 -6.791893555756082 1.4891918693044461 0.8519549600417122 1.3695549135282967 0.807264725066773 0.1130197355722318 0.23254587590848255 1.0188280906375105 0.05973594240795939 0.13963983172053848 1.6147542796447652e-07 6.791893555756082 0.5175999534865845 VDTCHTPFGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDTCHTPFGKR 11 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 6092240.0 994740.0 1151300.0 3946200.0 True False 827170.3844538985 1145097.7183848417 4771332.174832733 1.0 1.384355315308877 5.76825798469899 19.657825007567467 -6.924138826041872 0.7934178023909694 0.9169236721911088 6.5472093528231925 0.9952556530584288 0.14897778221931668 0.09579746932827875 0.09343806502778028 0.1312582435452986 0.41019094583909266 1.190861277922016e-07 6.924138826041872 5.630285680632084 up VDTCHTPFGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDTCHTPFGKR 11 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 29054700.0 3916000.0 2555700.0 22583000.0 True False 5069339.195900307 2413473.0483591435 18473125.72114776 1.0 0.4760922390655917 3.6440894971256625 22.273366269032028 -6.864434625323606 1.1632030579883859 0.7116756302009012 3.8109570943728093 0.9588020398966532 0.2814254962455999 0.14229871158342922 0.3633828086661109 0.18833972174041147 0.4420524545126806 1.3663607395248202e-07 6.864434625323606 3.099281464171908 up VDTNAPDLSLEGPEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDTNAPDLSLEGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9165400.0 2800200.0 0.0 6365200.0 False True 2711309.183751984 0.0 4697963.168093145 1.0 0.0 1.7327286744892645 21.370558209401928 -6.750210314277403 1.6489883338668858 0.4121346810151163 1.7362442544692516 0.6498961280659998 0.42021231259067493 0.29968300330714337 1.6033411402850357 0.20129616314082147 0.48859976893737844 1.7774184573395582e-07 6.750210314277403 1.3241095734541353 VDVADQAQDKDRDDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDVADQAQDKDRDDR 15 2 E7EX17;P23588-2;P23588;F8VP89;F8W0K0;F8VSC7 E7EX17 EIF4B Eukaryotic translation initiation factor 4B 0 10714070.0 3057200.0 1128470.0 6528400.0 False True 2960150.8594266754 1579073.9558933082 4818416.192198091 1.0 0.5334437435391872 1.6277603477044837 21.49723927173269 -6.790860583530989 1.4929034417609375 0.7395338160858681 1.6396747389142836 0.8040983992261962 0.1984501464977706 0.23407054402911315 1.0305923161746393 0.10462574710868984 0.244800701985512 1.6185995543016422e-07 6.790860583530989 0.9001409228284155 VDVAVNCAGIAVASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDVAVNCAGIAVASK 15 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 68027000.0 15510000.0 34836000.0 17681000.0 False True 20333760.199053664 29638604.58966447 15851539.728128053 1.0 1.4576056912013675 0.7795675552850174 24.277373692916413 -6.724900607195622 1.7416865760016447 1.276933393925661 0.7803211885366348 0.5355462834474813 0.19245546923334217 0.34587532211808714 2.0529791023940165 0.08765156970712405 0.2187797321693307 1.8840802314882838e-07 6.724900607195622 -0.4966122053890263 VDVAVNCAGIAVASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDVAVNCAGIAVASK 15 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 32136900.0 13956000.0 7265900.0 10915000.0 False True 13512974.419128187 10167211.761167947 8056034.057018898 1.0 0.7524036859550203 0.5961703032320731 23.687841933798367 -9.472484547639798 0.0821545981749038 1.7488753623187003 2.1812968250394503e-11 0.9999758546612899 0.0008169624287456548 0.9414158484756441 0.032127026684177336 0.4139053380759312 0.2639140446523693 3.3691120295492567e-10 9.472484547639798 -1.7488753622968873 VDVAVNCAGIAVASK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDVAVNCAGIAVASK 15 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 174356000.0 19924000.0 115560000.0 38872000.0 False True 30226164.639509063 94937415.12559886 31188932.161797155 1.0 3.1409018066918346 1.031852123276985 24.84929459300847 -6.642669476718807 2.0346778745838683 2.397143262672883 1.040625454210422 0.16504588283203336 0.9154099200386496 0.5266132473367844 4.1698833153178 0.3659527368144953 1.013782259976597 2.276829570873323e-07 6.642669476718807 -1.3565178084624607 VDVAVNCAGIAVASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDVAVNCAGIAVASK 15 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 86136000.0 15510000.0 28616000.0 42010000.0 False True 21244466.14198993 27351650.49954246 32088103.22310854 1.0 1.2874717734366414 1.5104217262342043 24.340583754439304 -6.973965521374735 0.13279261405319004 0.6685398924199862 2.1351362043755135 0.9999991447254012 0.00019313718599848698 0.07503560250866122 0.003996052568177108 0.013606318888578028 0.030038795452714803 1.0617798485215314e-07 6.973965521374735 1.4665963119555272 VDVAVNCAGIAVASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDVAVNCAGIAVASK 15 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 29571600.0 13956000.0 5662600.0 9953000.0 False True 11605032.35562922 5632094.449861904 12034126.28252754 1.0 0.4853148424984752 1.036974815213693 23.468247209232644 -11.867957483801304 17.874192883815915 0.9071558564680278 0.7850303459704779 0.0 0.25788715281255215 0.0 0.0 0.0 0.0749060293141364 1.3553220880471706e-12 11.867957483801304 -0.12212551049754983 VDVAVNCAGIAVASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDVAVNCAGIAVASK 15 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 77806000.0 19924000.0 28946000.0 28936000.0 False True 25792010.760755263 27335129.65442103 23669944.908432502 1.0 1.0598293366104574 0.9177239079183518 24.62042091510092 -6.79230126546429 1.4869069024021073 1.0333378719122008 0.9161102525786737 0.8087857386014261 0.025473798599129766 0.2319214814778263 1.01285957746932 0.013482685624364398 0.031517175365259775 1.6132390817897727e-07 6.79230126546429 -0.1172276193335271 VDVDIPDVNIEGPDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDVDIPDVNIEGPDAK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 10324000.0 4409600.0 1770300.0 4144100.0 False True 4269619.661693003 2477190.0219925395 3058635.889664865 1.0 0.5801898572413535 0.7163719797121332 22.02567612942092 -10.914436023177116 11.205397351046724 1.0386738644877074 0.6482809184767433 0.8989272357469438 0.05559611869043622 0.029890222495421136 0.00022824017792061698 0.029954901550529493 0.01794357015015253 1.2177663713281188e-11 10.914436023177116 -0.3903929460109641 VDVDVPDVNIEGPDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDVDVPDVNIEGPDAK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 31329700.0 2124700.0 17899000.0 11306000.0 False True 2785502.2756240685 15228538.969755523 10136163.574810011 1.0 5.467071092714758 3.6388997645098273 21.409506063932994 -9.335140765698805 9.16712115928443 0.9999991402832672 4.552985428612522 0.8343293045229907 0.7463478194157137 0.0 0.0 0.7226481687683695 0.24088272292278975 4.6223117643641167e-10 9.335140765698805 3.552986288329255 VDVDVPDVNIEGPDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDVDVPDVNIEGPDAK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 30632800.0 9505300.0 5795500.0 15332000.0 False True 9203559.454438165 8109673.373133242 11316089.249859238 1.0 0.8811453235326876 1.229533997784125 23.133760497246396 -6.814615064919432 1.394862979223213 0.9355693455583408 1.236305502968713 0.8715900583084971 0.05181706724398694 0.20056512669280108 0.7681505115915858 0.029201653949180246 0.06742536241270321 1.5324451361855267e-07 6.814615064919432 0.3007361574103723 VDVDVPDVNIEGPDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDVDVPDVNIEGPDAK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 35518700.0 2124700.0 17747000.0 15647000.0 False True 2910259.0078585423 16962878.858519033 11951500.860080434 1.0 5.828649207068631 4.106679449426295 21.472716125455886 -10.050249799125732 7.311553977577209 0.9999995487834111 4.967664328247464 0.8762187161732076 0.702991209787958 5.1731788574105464e-06 6.714155907250976e-07 0.6806683931117576 0.22688943733658032 8.907384524838975e-11 10.050249799125732 3.967664779464053 VDVDVPDVNIEGPDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDVDVPDVNIEGPDAK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 12645400.0 9505300.0 0.0 3140100.0 False True 7904078.106188187 0.0 3796680.391818021 1.0 0.0 0.4803444931605065 22.914165772680672 -10.082440672235105 6.290168483006492 1.0000012856193123 0.24017224658024838 0.769387960287209 0.1960998181665322 3.5353920288139757e-06 5.156988855746692e-07 0.18987315354970757 0.0632909441627699 8.27102489028293e-11 10.082440672235105 -0.759829039039064 VDVECPDVNIEGPEGK(ub)WK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDVECPDVNIEGPEGKWK 18 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 5923300.0 2389000.0 2292700.0 1241600.0 True False 3132002.1351089114 1950638.096874602 1113131.1422681871 1.0 0.6228086740454188 0.3554056141246786 21.578653765449292 -8.023500905131415 0.19664293397174157 1.2593716211614383 5.817920719272963e-15 0.9998463197989346 0.0032779993530266953 0.10066543522238809 0.03498941281285879 0.08229846532642543 0.10516729150125914 9.473252101418351e-09 8.023500905131415 -1.2593716211614325 down VDVECPDVNIEGPEGK(ub)WK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDVECPDVNIEGPEGKWK 18 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 8745100.0 4239100.0 2707600.0 1798400.0 True False 3524999.473971612 2693013.62138348 2174437.125137902 1.0 0.7639756094344222 0.6168616878367833 21.74919161154522 -10.080578443188726 0.07391681261815 1.8549741429423634 2.2285957644760927e-09 0.9999759758369731 0.0007734910522593358 1.7460198690298265 0.03569630787661718 0.5916418465522182 0.3208756596291779 8.306566701850072e-11 10.080578443188726 -1.8549741407137676 VDVEVPDVSLEGPEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDVEVPDVSLEGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 37053500.0 1760500.0 12415000.0 22878000.0 False True 2308032.5487062503 10562730.393290974 20510804.021272216 1.0 4.576508420217831 8.886704839916312 21.13823213885609 -6.9686390191553915 0.28885105762728797 0.14615922578870535 13.450007936244871 0.9999697342083799 0.017738687185303546 0.07674685070465134 0.010602988977854772 0.07576969489240405 0.39139039494381694 1.0748824717460228e-07 6.9686390191553915 13.303848710456165 VDVEVPDVSLEGPEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDVEVPDVSLEGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 29895200.0 9403400.0 5066800.0 15425000.0 False True 9104894.214160929 7089999.663012939 11384729.75991903 1.0 0.7787020360967835 1.2503967088615102 23.118210824572195 -6.7791425380484265 1.5393453273716469 0.874555404107998 1.2540243526185384 0.7642967331179601 0.09354992264048885 0.2519106952232968 1.179004478140915 0.04786994963274657 0.11302791514588918 1.6628667979628896e-07 6.7791425380484265 0.37946894851054036 VDVEVPDVSLEGPEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDVEVPDVSLEGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 38621500.0 1760500.0 24221000.0 12640000.0 False True 2411404.4257236132 23150836.13186393 9654692.328971462 1.0 9.600561351261863 4.003763212002187 21.20144220037898 -9.80065302546448 10.825434655620397 1.0000002796067475 6.802160760400724 0.588980891855055 2.2848832724244357 0.0 0.0 2.212328682566134 0.7374429051774636 1.5825118638297818e-10 9.80065302546448 5.802160480793977 VDVIPVNLPGEHGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDVIPVNLPGEHGQR 15 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 10200100.0 4256900.0 1799800.0 4143400.0 False True 4121767.03960925 2518469.525833008 3058119.2406644127 1.0 0.6110169501650833 0.7419437370614539 21.97483153604071 -10.347642522071379 4.989832481605333 1.0001797819719302 0.676480343613195 0.8906039681996696 0.05345063692662489 0.0001069611798503907 1.398381533577796e-05 0.051781892651407375 0.017251118888379952 4.4911491480298524e-11 10.347642522071379 -0.32369943835873527 VDVK(ub)GIFPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDVKGIFPR 9 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 24178400.0 6944900.0 8383300.0 8850200.0 True False 9104831.154507268 7132544.317847449 7934466.201113001 1.0 0.7833801853993245 0.871456709791385 23.11820083256542 -10.19055475939172 5.934198325400958 1.0000027138489498 0.8274184476135426 0.8365815296717019 0.0359570905130645 1.2910357029123406e-06 1.761202002094643e-07 0.03481585072383429 0.011605101061263254 6.448300093132734e-11 10.19055475939172 -0.17258426623540724 VDVK(ub)GIFPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VDVKGIFPR 9 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 38457600.0 9585800.0 13663600.0 15208200.0 True False 9281504.026001636 19119546.734732706 11224716.183779621 1.0 2.0599621226441664 1.2093639298473804 23.14592717586637 -10.154877939973362 4.558937151529563 0.9999109431381752 1.6346630262571558 0.4260442072851458 0.3472552581198058 40766357.449559964 90805729.72613586 22374.872557017687 0.11887469603869912 7.00038716756375e-11 10.154877939973362 0.6347520831189806 VDVK(ub)GIFPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDVKGIFPR 9 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 36017000.0 5712200.0 7573500.0 22731300.0 True False 8665825.017757677 6221949.752974418 18238448.5915173 1.0 0.7179870053023961 2.1046407646293077 23.04690567501289 -6.853740015185806 1.2168281728690922 0.8488705631387112 2.1642283964025104 0.945578216593937 0.13959388372974268 0.1533954741905491 0.4351828764943526 0.08967070498690377 0.2080719467775573 1.40042541838179e-07 6.853740015185806 1.3153578332637992 up VDVK(ub)GIFPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDVKGIFPR 9 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 32513800.0 6944900.0 12567500.0 13001400.0 True False 9512617.208865622 12012226.294835063 9930737.092238106 1.0 1.2627677568734545 1.0439542424752257 23.181410894088312 -10.324550011516687 5.106925255546215 0.9999455193443144 1.1533609996743643 0.39575883697079717 0.08933024318355101 5.543146178576683e-05 7.331370408110818e-06 0.08652432614275316 0.02883121201353388 4.7364176245087986e-11 10.324550011516687 0.15341548033004992 VDVK(ub)GIFPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VDVKGIFPR 9 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 39899800.0 9585800.0 19042100.0 11271900.0 True False 7971017.422942854 18939516.427739095 13628802.174622959 1.0 2.3760475511226185 1.709794553377263 22.926332451300645 -10.091676515819184 4.983437858803005 0.9999689777695024 2.0429210522545715 0.7656491420575924 0.27199664736201445 94588570.27946556 3.0646233469643582 33671.35172339118 0.09311168707628653 8.096987786390622e-11 10.091676515819184 1.042952074485069 VDVK(ub)GIFPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VDVKGIFPR 9 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 20392500.0 5712200.0 9504000.0 5176300.0 True False 7394555.504295645 8975094.045312554 4234266.513323168 1.0 1.2137435495749194 0.5726194780556314 22.81803199710534 -6.8168359717617495 1.3856612866701201 1.1155853824215107 0.559566366438286 0.8769220309426238 0.09350796280730284 0.19762158687526413 0.7464500951432257 0.053042921985187244 0.12236148998672852 1.5246284804375456e-07 6.8168359717617495 -0.5560190159832248 VDVNAPDVQAPDWHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDVNAPDVQAPDWHLK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 12844000.0 1349400.0 6040500.0 5454100.0 False True 1769076.4676081885 5139280.945684588 4889762.051421478 1.0 2.9050643314660975 2.7640196119009444 20.75456497860457 -10.38676036826045 5.627536346983182 0.999350619362461 2.834541971683529 0.995586343227855 0.0575812656414565 0.00046927049447729053 5.1136748297032566e-05 0.055768560219328016 0.01858427357357151 4.104305047736399e-11 10.38676036826045 1.835191352321068 VDVNAPDVQAPDWHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDVNAPDVQAPDWHLK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 62831100.0 6436100.0 44222000.0 12173000.0 False True 9764034.241936589 36330238.59193696 9767001.21438457 1.0 3.720822530086832 1.0003038674767484 23.21904592390509 -6.646131771356313 2.0222179197860983 2.770891487840561 1.0116768350953917 0.17859291689228363 1.162382144009054 0.5180544687640919 4.056096042011291 0.46687683571459115 1.2874093851120891 2.2587503280492682e-07 6.646131771356313 -1.7592146527451693 VDVNAPDVQAPDWHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDVNAPDVQAPDWHLK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 13055400.0 1349400.0 5250400.0 6455600.0 False True 1848309.646163843 5018419.967249013 4930920.237255397 1.0 2.7151402783969214 2.667799871893487 20.81777504012746 -10.272783913711269 4.853179885239338 0.9995000186154283 2.6914700751470724 0.999412860141347 0.01932664003133434 0.00010458101946400846 1.5670760439299123e-05 0.018717872516407674 0.006237646247374605 5.3360032606202585e-11 10.272783913711269 1.6919700565316442 VDVSAPDVEAHGPEWNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDVSAPDVEAHGPEWNLK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 18312600.0 0.0 10487000.0 7825600.0 False True 0.0 10023649.664128536 5977354.453291067 0.0 VDYIMQLPVPMDAALNK(ub)EELLEYEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VDYIMQLPVPMDAALNKEELLEYEEK 26 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 47785600.0 9810600.0 22429000.0 15546000.0 True False 14883397.450931942 18426369.711423133 12473326.285946153 1.0 1.238048622444692 0.8380698242500485 23.82720055397298 -6.745486259058938 1.6665055096151875 1.1407319876024673 0.8375391050625848 0.6293188092174238 0.10001551082415772 0.3079963283985055 1.6814679322874033 0.04743848127016558 0.11572088786667899 1.79685793129494e-07 6.745486259058938 -0.3031928825398825 VDYSGGFEPFSVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VDYSGGFEPFSVLR 14 0 F8W7U8;P49959-2;P49959;P49959-3 F8W7U8 MRE11A Double-strand break repair protein MRE11A 0 4008800.0 1063000.0 1808300.0 1137500.0 False True 1393603.2941066439 1538508.6886981917 1019802.4116704753 1.0 1.1039789409255365 0.7317738240021956 20.410388508524065 -6.832139672075419 1.318209714721055 1.0554850997338443 0.7213057658818858 0.9100958723507303 0.047016785841739434 0.17819465369190793 0.6048068633342277 0.027996902475927423 0.06443163400802976 1.4718390727963187e-07 6.832139672075419 -0.3341793338519585 VDYSGGFEPFSVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VDYSGGFEPFSVLR 14 0 F8W7U8;P49959-2;P49959;P49959-3 F8W7U8 MRE11A Double-strand break repair protein MRE11A 0 4271200.0 1063000.0 1389300.0 1818900.0 False True 1456019.8264948616 1327916.132199272 1389313.2814213762 1.0 0.9120178915393075 0.9541856890547493 20.473598570046956 -10.13060593105137 4.448809219275154 1.0000090708088647 0.9331017902943538 0.7704250279568016 0.0172149312573782 1.549016827484598e-06 3.0270833325497135e-07 0.016670545522575474 0.005556095170889736 7.402766806489945e-11 10.13060593105137 -0.06690728051451089 VEAIDVEEAK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEAIDVEEAKR 11 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 17379800.0 5196800.0 5763600.0 6419400.0 True False 6813055.125882792 4903693.346336831 5755182.067232918 1.0 0.719749547850817 0.8447285338069532 22.699870449290774 -10.028465822123339 4.4901076803088 1.000008958134883 0.782239040823136 0.8018959910208668 0.0510224574306333 60740073070.46686 54395049865.347115 7088444.573384987 0.01867264805616512 9.365569216538106e-11 10.028465822123339 -0.217769917311747 VEAIDVEEAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEAIDVEEAKR 11 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 27875800.0 6912500.0 9152300.0 11811000.0 True False 6693066.471211197 12806861.118613988 8717344.777595056 1.0 1.9134519541528505 1.302444076282652 22.674235911613422 -10.433655056701431 5.359576453099792 0.9994396101502073 1.6079480152175392 0.5689678187004072 0.24944292160048392 0.0016717832594614417 0.00017665614790588735 0.24173302233999852 0.08050735676566316 3.684214803866942e-11 10.433655056701431 0.6085084050673318 VEAIDVEEAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEAIDVEEAKR 11 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 34635600.0 11947000.0 7939600.0 14749000.0 True False 18124472.442692984 6522716.347622063 11833853.685283659 1.0 0.3598844804032762 0.652921276616499 24.11143566676601 -10.4743527454659 6.21375188321251 1.000267381281595 0.5064028785099726 0.7909274595385871 0.11963177109705571 0.0004433656442563817 3.75062362646975e-05 0.11589400476882813 0.03861098809468287 3.354650299869926e-11 10.4743527454659 -0.4938645027716224 VEAIDVEEAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEAIDVEEAKR 11 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 16460900.0 5196800.0 4405600.0 6858500.0 True False 7118197.398239414 4210946.024629033 5238663.555241363 1.0 0.5915747750505699 0.7359536778984344 22.763080510813666 -10.296649186534989 6.404393699157982 1.0000105222447628 0.6637642264745021 0.8785131742780148 0.05894244026668911 8.855860876662781e-06 9.72659851569378e-07 0.05707255649230775 0.01902359079480932 5.0506911647532134e-11 10.296649186534989 -0.3362462957702608 VEAIDVEEAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEAIDVEEAKR 11 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 25794800.0 6912500.0 11769000.0 7113300.0 True False 5748050.025672605 11705598.061036395 8600658.141816845 1.0 2.0364467965232556 1.4962740587509837 22.4546411870477 -10.444976468878883 5.624092775945787 0.9994206657190982 1.766360427637121 0.7285363561419242 0.2205245967507201 0.0016030387691992726 0.00015819855756120496 0.21367129571769408 0.07117400755371962 3.589413824268207e-11 10.444976468878883 0.7669397619180228 VEAIDVEEAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEAIDVEEAKR 11 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 34261900.0 11947000.0 6950900.0 15364000.0 True False 15465627.010577358 6564076.304667832 12567909.647952607 1.0 0.4244300150377663 0.8126349897975087 23.88256198885846 -10.10441461557755 5.726395796249647 1.0000028377959187 0.6185325024176214 0.5628326839662128 0.15848401729537048 5.74182287119732e-06 8.978612261778079e-07 0.15345263185122598 0.051150496635398016 7.862947653549894e-11 10.10441461557755 -0.38147033537829733 VEAIPNCK(ub)SEEETSPLVTHQNPAGPVASAPELESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEAIPNCKSEEETSPLVTHQNPAGPVASAPELESK 35 1 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 26756000.0 9424500.0 9916500.0 7415000.0 True False 12355610.76698783 8436996.854214257 6647766.9297024775 1.0 0.6828474134808885 0.5380362861109402 23.55866299246022 -13.999999999999845 0.10545564112036396 2.5442746818038287 0.2541221189837698 0.999766162407985 0.002950093398350702 12.041302578952852 0.09776850756651187 3.995395336027959 0.25254535182190535 1.0000000000003558e-14 13.999999999999845 -2.290152562820059 VEAIPNCK(ub)SEEETSPLVTHQNPAGPVASAPELESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEAIPNCKSEEETSPLVTHQNPAGPVASAPELESK 35 1 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 38024000.0 15735000.0 11213000.0 11076000.0 True False 23871145.382587638 9211952.542431122 8886823.745216751 1.0 0.3859032482434047 0.372283089176738 24.50876445552167 VEAIPNCK(ub)SEEETSPLVTHQNPAGPVASAPELESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEAIPNCKSEEETSPLVTHQNPAGPVASAPELESK 35 1 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 22747500.0 9424500.0 6343600.0 6979400.0 True False 12908992.337536048 6063318.776520044 5331009.465255018 1.0 0.46969729456647547 0.41296867531277454 23.621873053983112 -13.999999999999998 0.31570777085442603 6.300933736012024 0.4011589714371174 0.9996844654706495 0.004696157739842514 17.686310416737225 0.17900360268719825 61.78162079847702 0.019209941513055714 1.0000000000000041e-14 13.999999999999998 -5.899774764574907 VEAIPNCK(ub)SEEETSPLVTHQNPAGPVASAPELESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEAIPNCKSEEETSPLVTHQNPAGPVASAPELESK 35 1 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 15082800.0 7395600.0 5114600.0 2572600.0 True False 6149769.080631366 5087046.634631391 3110518.7656415496 1.0 0.827193113746822 0.5057944005471842 22.55210080864067 -6.961440207170499 0.41463701052746316 1.015053837225009 0.3059156759340873 0.9998199401435998 0.002747807705704111 0.07919060217646941 0.019259582762642835 0.0041455076950168285 0.026795512786514073 1.0928480780545769e-07 6.961440207170499 -0.7091381612909218 VEAIPNCK(ub)SEEETSPLVTHQNPAGPVASAPELESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEAIPNCKSEEETSPLVTHQNPAGPVASAPELESK 35 1 P43007;P43007-2 P43007 SLC1A4 Neutral amino acid transporter A 1 32988800.0 15735000.0 8581200.0 8672600.0 True False 20369267.683220483 8103648.676518965 7094275.788390652 1.0 0.39783701616305417 0.3482833010356419 24.27989077761412 -13.999999999999998 0.3538761470385899 8.584786454388839 0.34178422489783084 0.9997620242055318 0.004569837321691654 21.051849207302926 0.19177908344440842 120.24859617039542 0.01459226155971512 1.0000000000000041e-14 13.999999999999998 -8.243002229491008 VEAK(ub)PCTSNCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEAKPCTSNCR 11 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 3784260.0 1453300.0 1643500.0 687460.0 True False 1905290.3737772186 1398296.2063128226 616328.2337819642 1.0 0.7339018899994307 0.32348257371400024 20.86157945622082 -6.964790240875354 0.36163401664746136 1.0347121887754214 0.008571892861072457 0.9999087559331593 0.0026581164878540253 0.07803221934520252 0.015111353949559944 0.005488549985573116 0.03502102738342268 1.0844505644149908e-07 6.964790240875354 -1.0261402959143489 down VEAK(ub)PCTSNCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEAKPCTSNCR 11 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 3477170.0 1453300.0 1316700.0 707170.0 True False 1990624.2839557666 1258523.8402553655 540151.0106233195 1.0 0.6322257044681622 0.2713475440729237 20.92478951774371 -7.500062608408806 0.3060627900953132 1.0840487232337737 2.897933178081e-16 0.9996758829470045 0.005355524119996418 0.12339346174413883 0.03215305018674481 0.022391918846624462 0.06509512852492189 3.161821815319892e-08 7.500062608408806 -1.0840487232337734 down VEAKPEVQSQPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEAKPEVQSQPPR 13 1 Q9UN86-2;Q9UN86 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 6772760.0 1926900.0 950360.0 3895500.0 False True 1865731.6142317345 1329843.7040619291 2875151.6875050017 1.0 0.7127733131163821 1.5410317676848302 20.83131003854445 -6.813037406432558 1.4015844685647632 0.8440125577765368 1.5565709514374344 0.8676393792858621 0.12492869640645651 0.20268978490905112 0.7841425233661544 0.07007243980678418 0.1618914478436226 1.538022162451216e-07 6.813037406432558 0.7125583936608976 VEANSTLLNVHIVFEGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEANSTLLNVHIVFEGEK 18 0 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 59449000.0 20411000.0 39038000.0 0.0 False True 30964979.243978113 32071363.894713815 0.0 1.0 1.035730191905453 0.0 24.88413414321967 -6.99810438847988 1.1247374841353712 1.033894771350606 8.925459204788329e-20 0.982889398009885 0.06279386227524966 0.09242400709978615 0.2289832265282873 0.04699622493631333 0.08629711242835769 1.0043743464721782e-07 6.99810438847988 -1.033894771350606 down VEANSTLLNVHIVFEGEKEFDQNVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEANSTLLNVHIVFEGEKEFDQNVK 25 1 Q9UHD1;Q9UHD1-2;E9PHZ2 Q9UHD1 CHORDC1 Cysteine and histidine-rich domain-containing protein 1 0 97957000.0 21552000.0 37115000.0 39290000.0 False True 32695959.662251577 30491538.2691814 31524314.278581224 1.0 0.9325781712529073 0.964165438305729 24.962609032798188 -10.097706592887114 4.20930158389452 1.0000076726596883 0.9483718047687181 0.7807957337634993 0.012895447809796613 17948615.567707602 0.22350801940939766 1429.9282529345894 0.004414454778899166 7.985339905192164e-11 10.097706592887114 -0.05163586789097019 VEAQVYILSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEAQVYILSK 10 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 27303000.0 7238900.0 11246000.0 8818100.0 False True 9490268.001607321 9568140.63656467 7905687.6011880515 1.0 1.0082055253807543 0.8330310166002797 23.178017398312438 -6.895913128678878 0.9867642214295019 1.0081220716200663 0.8160975160735232 0.9844203412941867 0.010074541674108607 0.11447569057906792 0.19487981314422012 0.00771247011641149 0.019684715634878943 1.270828281799915e-07 6.895913128678878 -0.19202455554654307 VEAQVYILSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEAQVYILSK 10 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 29619800.0 9768600.0 5364200.0 14487000.0 False True 9458501.140061295 7506153.033933455 10692420.099315856 1.0 0.7935880032980376 1.1304560776578354 23.173180151501338 -6.740881836362328 1.6833402403645856 0.8773134413039041 1.1306972441174559 0.6089686597616506 0.08672395657959127 0.3162133798655886 1.7596789359678906 0.04075003939056819 0.0999052247040959 1.8160096988042813e-07 6.740881836362328 0.2533838028135518 VEAQVYILSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEAQVYILSK 10 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 197168000.0 31758000.0 91832000.0 73578000.0 False True 48179207.82079548 75443862.11330913 59035276.0496169 1.0 1.5659008424116403 1.2253268312173378 25.521907336691914 -10.387336935778201 5.3173133870865765 0.9997814504283241 1.3956138368144984 0.6427440914747922 0.13903875784652717 0.0003604261252745337 4.1528746423228774e-05 0.13469709465589053 0.04487456613474242 4.098859805050528e-11 10.387336935778201 0.39583238638617424 VEAQVYILSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEAQVYILSK 10 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 36146900.0 7238900.0 13232000.0 15676000.0 False True 9915316.953916887 12647366.4876274 11973651.657354187 1.0 1.2755382955893568 1.2075914177029095 23.24122745983533 -10.040823067720591 4.317987134068853 0.9999830977470061 1.2415648566464486 0.9439857856318035 0.027739196893141964 9597872.778438726 0.16971349606716074 1663.382468031429 0.009495864893195035 9.102840483039812e-11 10.040823067720591 0.24158175889944244 VEAQVYILSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEAQVYILSK 10 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 20146600.0 9768600.0 5160300.0 5217700.0 False True 8123023.722355938 5132500.439660648 6308696.946080979 1.0 0.6318460483545231 0.7766439150877248 22.953585426935614 -10.215453758508081 4.967942327615363 1.0000374413128388 0.704244981720781 0.8476216130072238 0.05911348155783418 2.4517247187104345e-05 3.871727180144717e-06 0.05724361762459212 0.01907879413398245 6.089003749591288e-11 10.215453758508081 -0.2957924595920578 VEAQVYILSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEAQVYILSK 10 0 P49411 P49411 TUFM Elongation factor Tu, mitochondrial 0 162273000.0 31758000.0 73916000.0 56599000.0 False True 41111357.04376961 69802509.62261394 46298562.75478195 1.0 1.697888725694411 1.1261745192572876 25.293033658784363 -10.242970268482102 4.709679029658223 0.9998879108703275 1.412031622477189 0.40917034503454275 0.2334013474164549 0.00027477511371252393 4.416710374378217e-05 0.22605101835237917 0.07532996095987425 5.7151776106701764e-11 10.242970268482102 0.4121437116068615 VEATK(ub)NETSAPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEATKNETSAPFK 13 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 3948400.0 870500.0 1391100.0 1686800.0 True False 842866.453987609 1946573.4844906672 1244976.4770846977 1.0 2.309468451711905 1.4770744181295892 19.684944539255092 -10.127961541129089 5.292934237816189 0.9999783558190414 1.8932714349213158 0.6055993134428301 0.3398234412042894 8.679694395716353e-05 1.4299418294822543e-05 0.32904058102083633 0.10967754403597198 7.447979264341752e-11 10.127961541129089 0.8932930791022744 VEATK(ub)NETSAPFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEATKNETSAPFK 13 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 3185900.0 870500.0 1701400.0 614000.0 True False 723859.3196886805 1692234.220498541 742384.5611847596 1.0 2.3377943399642103 1.0255923229724342 19.465349814689368 -6.641700509446348 2.038056873951226 1.8737300556235033 1.0310496295972056 0.16111471028776525 0.5721647041495633 0.5292053446925551 4.203115252435101 0.22843927764595431 0.6336805264910119 2.2819151438931966e-07 6.641700509446348 -0.8426804260262977 VEATK(ub)NETSAPFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEATKNETSAPFK 13 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 7432400.0 2044100.0 3244300.0 2144000.0 True False 2646127.74523489 3063751.8530310947 1753813.999297735 1.0 1.1578246207305207 0.662785083772308 21.33545128058861 -6.82094060523085 1.3677762294346993 1.084986499860841 0.6517560280012877 0.8865397735770548 0.06954868346718752 0.19226058830564152 0.706497161645414 0.039954883168885916 0.09206833469711663 1.5102866891290194e-07 6.82094060523085 -0.4332304718595532 VECSK(ub)FGQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VECSKFGQIR 10 1 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 6689600.0 2169200.0 2207500.0 2312900.0 True False 2971211.8604258215 2109965.350773694 1766640.6556707383 1.0 0.7101362844153775 0.5945858924437488 21.502620048643696 -13.999999999999998 0.1268849491994787 2.3774834863615593 0.4261764629339906 0.9996599370824757 0.003144758353667973 11.94266959920628 0.11045292467319191 4.115049028637497 0.14962060410310066 1.0000000000000041e-14 13.999999999999998 -1.9513070234275687 VECSK(ub)FGQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VECSKFGQIR 10 1 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 4479600.0 1388800.0 1220000.0 1870800.0 True False 1154848.7342718448 1213427.61784896 2261975.6303981217 1.0 1.0507242912761647 1.958676979305296 20.139272464595386 -6.918412397251375 0.8364194181171879 0.978797618253628 2.099875189779457 0.9937284180252612 0.03488116457172513 0.09911481277244862 0.11052177282684249 0.029803770984491988 0.08796511242511701 1.206667463902588e-07 6.918412397251375 1.121077571525829 VECSK(ub)FGQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VECSKFGQIR 10 1 O43719 O43719 HTATSF1 HIV Tat-specific factor 1 1 13753100.0 2684000.0 3156900.0 7912200.0 True False 3474490.9095496475 2981215.73986187 6472260.786027766 1.0 0.8580295120841994 1.862793990405541 21.728370175628516 -6.871103959308645 1.1281638786781976 0.9191348536807061 1.9229051599566096 0.9657764068515367 0.0821359214452811 0.13580465655720816 0.32236268740155727 0.05646108181480105 0.13394376890244905 1.34553822708208e-07 6.871103959308645 1.0037703062759036 VECVLAELK(ub)GVTCENR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VECVLAELKGVTCENR 16 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 28506500.0 3542500.0 10753000.0 14211000.0 True False 4644251.805618795 9148694.31486571 12740582.041537672 1.0 1.9698962712997747 2.7433013055243096 22.14701476479834 -6.973683860167733 0.14535399853462502 0.040188114298788644 4.69327132933622 0.9999987326855789 0.0008028703073367099 0.07512445997848612 0.004423447082352026 0.04136492835735365 0.09837375040023699 1.0624686880195385e-07 6.973683860167733 4.653083215037431 VECVLAELK(ub)GVTCENR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VECVLAELKGVTCENR 16 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 254078000.0 16938000.0 45671000.0 191469000.0 True False 25696184.33366821 37520653.22084828 153625068.22615603 1.0 1.4601643860285964 5.978516741291822 24.615050811506734 -6.926495331601688 0.7750152110804585 0.9216292799813149 6.828428633887808 0.9958035171942329 0.14551609465864132 0.09449901840998053 0.08689661317726054 0.12990566341317775 0.41698912500262797 1.1844170986833741e-07 6.926495331601688 5.906799353906493 up VECVLAELK(ub)GVTCENR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VECVLAELKGVTCENR 16 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 44827900.0 3542500.0 8418400.0 32867000.0 True False 4852257.982462878 8046447.252073962 25104491.51711275 1.0 1.658289250315128 5.17377509766502 22.21022482632123 -6.9383474050583445 0.6747613290672838 0.9591846347277235 6.077415402456059 0.9979393540786977 0.08317119270088769 0.08852868119536664 0.05810369880225526 0.07998108121221878 0.3048396126439695 1.1525309452345096e-07 6.9383474050583445 5.118230767728336 VECVLAELK(ub)GVTCENR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VECVLAELKGVTCENR 16 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 211216000.0 16938000.0 33992000.0 160286000.0 True False 21926574.897895675 32100315.31863055 131115592.67324468 1.0 1.4639913195795693 5.97975713415359 24.386177133599183 -6.926641959639833 0.7738553373057183 0.9221058133624369 6.832238822552141 0.9958361418692938 0.14493741373718122 0.09441949280156399 0.08649879802947946 0.1294965729870671 0.41639861585623283 1.1840172790938321e-07 6.926641959639833 5.910133009189704 up VECYDYDNDGSHDLIGTFQTTMTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VECYDYDNDGSHDLIGTFQTTMTK 24 0 O75131;H0YB26 O75131 CPNE3 Copine-3 0 9173300.0 2098300.0 4400700.0 2674300.0 False True 2750891.619966103 3744132.7137942426 2397589.0896970127 1.0 1.3610615142447444 0.8715679935535069 21.391467870585885 -6.709086859278857 1.7985319053480322 1.2221796959274538 0.8727519881858448 0.4607403047102958 0.15217114447761704 0.3769090638802124 2.376057901482329 0.06734637368024875 0.1712765293986545 1.9539486252476106e-07 6.709086859278857 -0.34942770774160903 VECYDYDNDGSHDLIGTFQTTMTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VECYDYDNDGSHDLIGTFQTTMTK 24 0 O75131;H0YB26 O75131 CPNE3 Copine-3 0 10184800.0 2098300.0 2845900.0 5240600.0 False True 2874098.2144253664 2720158.727867204 4002878.2135449243 1.0 0.9464390305851326 1.3927423194705408 21.454677932108776 -6.876927389964677 1.0968346660120227 0.9679817113619349 1.4225602874564098 0.9711194032477237 0.03381356096573692 0.13038456803706067 0.2890535118165245 0.02381037785742934 0.05715414289578566 1.3276164044042508e-07 6.876927389964677 0.45457857609447494 VEDAMLMFDK(ub)TTNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEDAMLMFDKTTNR 14 1 Q96DH6;B4DHE8;Q96DH6-2;B4DM51;Q96DH6-3 Q96DH6 MSI2 RNA-binding protein Musashi homolog 2 1 22294300.0 5355200.0 5101100.0 11838000.0 True False 5185202.107288282 7137995.831885074 8737272.667612422 1.0 1.3766089892334108 1.6850399438300343 22.30596879240316 -6.9734068701463094 0.15671341572318875 0.67340236626732 2.3964061751531887 0.9999982337521147 0.0003722456563972642 0.07521193572017039 0.004821617463431647 0.014734801968836255 0.03747089490039122 1.0631465393530729e-07 6.9734068701463094 1.7230038088858688 VEDAMLMFDK(ub)TTNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEDAMLMFDKTTNR 14 1 Q96DH6;B4DHE8;Q96DH6-2;B4DM51;Q96DH6-3 Q96DH6 MSI2 RNA-binding protein Musashi homolog 2 1 50168700.0 8337700.0 22803000.0 19028000.0 True False 12648900.46751831 18733626.4893478 15267107.459731318 1.0 1.481047822097639 1.2069908763165955 23.59250864525741 -10.171625012837922 4.632717993555845 0.9999543289633013 1.3440193492054489 0.6775217674836818 0.11188327964496346 5.7785016605135896e-05 1.0332671784463968e-05 0.10834623246020145 0.036110173226075314 6.73557982080927e-11 10.171625012837922 0.3440650202421476 VEDAMLMFDK(ub)TTNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEDAMLMFDKTTNR 14 1 Q96DH6;B4DHE8;Q96DH6-2;B4DM51;Q96DH6-3 Q96DH6 MSI2 RNA-binding protein Musashi homolog 2 1 11401300.0 3131700.0 3591600.0 4678000.0 True False 4289574.121010308 3432911.236167067 3573152.7464342173 1.0 0.8002918563296736 0.8329854306358612 22.032402990008052 -10.402061588195975 5.2560184494997095 1.0001319874046444 0.8166386434827623 0.9767117456555483 0.013347095819672122 2.0658043820080513e-05 2.3501318923371185e-06 0.012932539345803379 0.004307756652482837 3.962218412348116e-11 10.402061588195975 -0.1834933439218821 VEDAMLMFDK(ub)TTNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEDAMLMFDKTTNR 14 1 Q96DH6;B4DHE8;Q96DH6-2;B4DM51;Q96DH6-3 Q96DH6 MSI2 RNA-binding protein Musashi homolog 2 1 19056000.0 5355200.0 7309200.0 6391600.0 True False 4453086.075585096 7269823.888837398 7728054.008580628 1.0 1.6325361256086224 1.735437823883795 22.086374067837436 -11.377240080810525 0.3177294891238497 2.1001641825505406e-11 1.7596136098938195 0.99939075339102 0.00802588936108761 3.623395347463383 0.16583857891735396 2.5525474241393695 0.03449213684427711 4.195270026244536e-12 11.377240080810525 1.759613609872818 VEDAMLMFDK(ub)TTNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEDAMLMFDKTTNR 14 1 Q96DH6;B4DHE8;Q96DH6-2;B4DM51;Q96DH6-3 Q96DH6 MSI2 RNA-binding protein Musashi homolog 2 1 51566700.0 8337700.0 17663000.0 25566000.0 True False 10793317.010637885 16680038.522975162 20913250.329312466 1.0 1.5454043003217017 1.937611052163147 23.36363496734986 -7.15555032246894 0.09992636659065318 1.910953651046714e-09 3.422107216845128 0.9999995865507285 0.00024715168236536753 0.08535254531371517 0.0038799199264114795 0.04886926436620741 0.08169192739173907 6.989557428327586e-08 7.15555032246894 3.4221072149341745 VEDLLK(ub)RPDVDVNGQCAGHTAMQAASQNGHVDILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILK 35 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 55950200.0 14384500.0 7687700.0 33878000.0 True False 13927871.921177229 10757438.700825883 25004335.48178525 1.0 0.7723677214800687 1.7952732207255824 23.731471505546097 -6.848303474790218 1.2431648405887523 0.8786762655839757 1.8348650441116665 0.9378117279399218 0.10935352728395427 0.15933305334203257 0.47469566103310584 0.06885886736236604 0.15918857934955893 1.4180662639751213e-07 6.848303474790218 0.9561887785276908 VEDLLK(ub)RPDVDVNGQCAGHTAMQAASQNGHVDILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILK 35 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 270029000.0 19751000.0 171661000.0 78617000.0 True False 29963710.991514973 141026753.3564853 63078315.49094484 1.0 4.706585022009484 2.1051569850212197 24.836712976175995 -6.553839957365104 2.3718422820151073 3.5624512067631646 2.1085483270888146 0.0 1.620847305833327 0.7814272718174898 8.23177679487706 0.5838870020594302 1.8274177330297283 2.793573116192285e-07 6.553839957365104 -1.45390287967435 VEDLLK(ub)RPDVDVNGQCAGHTAMQAASQNGHVDILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILK 35 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 46355700.0 14384500.0 8313000.0 23658200.0 True False 11961349.091397861 8268216.2189986985 28605020.23684249 1.0 0.6912444537669149 2.3914543433410964 23.511876780980373 -6.859874477347277 1.1862511549273065 0.8325210368402162 2.4736370722700576 0.953498227141958 0.15947500931827074 0.14693423691629492 0.3929449200780562 0.1048536401262336 0.24474447387099885 1.380783290020083e-07 6.859874477347277 1.6411160354298415 up VEDLLK(ub)RPDVDVNGQCAGHTAMQAASQNGHVDILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEDLLKRPDVDVNGQCAGHTAMQAASQNGHVDILK 35 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 156976000.0 19751000.0 83839000.0 53386000.0 True False 25568058.850415472 79173285.9495959 43670295.786617935 1.0 3.096570076469038 1.7080020052405467 24.607839298268445 -10.451067588855345 6.1459965224354765 0.9994069392803356 2.4022860408547837 0.5762367201506121 0.5668805412717357 0.004608274790830445 0.0004115884250548399 0.5490728791795049 0.18295990796953981 3.5394225308586554e-11 10.451067588855345 1.402879101574448 VEDMAELTCLNEASVLHNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEDMAELTCLNEASVLHNLK 20 0 P35579;Q5BKV1;B1AH99;E7ERA5;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 8957420.0 739420.0 4969000.0 3249000.0 False True 969386.7805534651 4227644.569010296 2912824.6466086814 1.0 4.361153518718864 3.0048116036259778 19.886712883163533 -9.50194541173364 10.10455064177255 0.9999462278304024 3.682982561173345 0.8391554497489379 0.5537242689914563 0.0 0.0 0.5361412176554516 0.17871373921848382 3.1481439924486943e-10 9.50194541173364 2.6830363333429426 VEDMAELTCLNEASVLHNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEDMAELTCLNEASVLHNLK 20 0 P35579;Q5BKV1;B1AH99;E7ERA5;P35580;P35580-5;P35580-2;P35580-3;P35580-4 P35579;P35580 MYH9;MYH10 Myosin-9;Myosin-10 0 15598020.0 739420.0 3194600.0 11664000.0 False True 1012803.5560741572 3053452.0088705015 8909203.427620517 1.0 3.0148511925711765 8.796575973878381 19.949922944686424 -6.952445670139161 0.5313169340253912 0.9096669544389011 11.164819625509743 0.9993794951807601 0.08231365492190632 0.0825183078996322 0.03201126138768935 0.09165579118779701 0.47820038194318043 1.1157177179340834e-07 6.952445670139161 10.255152671070842 VEDVSAVEIVGGATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEDVSAVEIVGGATR 15 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 10408800.0 0.0 3785500.0 6623300.0 False True 0.0 3220718.1557634277 5937984.451179834 0.0 VEDVSAVEIVGGATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEDVSAVEIVGGATR 15 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 8076300.0 0.0 3497400.0 4578900.0 False True 0.0 3342873.30364481 3497458.125405657 0.0 VEEAEPEEFVVEK(ub)VLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEEAEPEEFVVEKVLDR 17 1 Q13185;S4R2Y4;C9JMM0;B8ZZ43 Q13185 CBX3 Chromobox protein homolog 3 1 14435400.0 5256300.0 5515400.0 3663700.0 True False 5089441.633653155 7717727.982431035 2704067.0613559415 1.0 1.5164193909600492 0.5313091800632336 22.27907595518372 -6.764248945970601 1.596360684868806 1.2983736028117625 0.5269191944358581 0.7081184334693026 0.2173613754790649 0.27583439567518575 1.386256717686233 0.10738291370484468 0.25699916081655405 1.7208818495517473e-07 6.764248945970601 -0.7714544083759044 VEEAEPEEFVVEK(ub)VLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEEAEPEEFVVEKVLDR 17 1 Q13185;S4R2Y4;C9JMM0;B8ZZ43 Q13185 CBX3 Chromobox protein homolog 3 1 12932800.0 5256300.0 5283700.0 2392800.0 True False 4370846.343572214 5255235.659367666 2893123.416942817 1.0 1.2023382306943913 0.661913778139892 22.059481230617997 -6.805311909474966 1.4342106361468845 1.1109012101877394 0.6534465569716562 0.8471972426321615 0.08714542380288542 0.2132766367326869 0.8654778470862466 0.047789908611779744 0.1107978681161062 1.5656262364298576e-07 6.805311909474966 -0.45745465321608314 VEEAK(ub)SSLAMNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEEAKSSLAMNR 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 31831400.0 1379800.0 4923000.0 25528600.0 True False 2093257.4768919211 4044452.186425435 20482861.020417113 1.0 1.9321331613876078 9.785160806319041 20.997318347610964 -6.929146281707877 0.7537691875434698 0.8767204424791389 11.362836244977526 0.996367753699461 0.23746112293577812 0.09308350754248061 0.07987025676666192 0.21525011940676503 0.7139282328567569 1.1772093919103024e-07 6.929146281707877 10.486115802498388 VEEAK(ub)SSLAMNR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VEEAKSSLAMNR 12 1 E9PD53;Q9NTJ3;Q9NTJ3-2 E9PD53 SMC4 Structural maintenance of chromosomes protein;Structural maintenance of chromosomes protein 4 1 39074980.0 2148280.0 5240800.0 31685900.0 True False 2780990.8089297004 4949144.872966543 25919391.32478921 1.0 1.7796336676392268 9.32020028313744 21.407167545963663 -6.926746476406113 0.7730362312872553 0.8704440101392478 10.747314962707163 0.9958591905982036 0.24143425372720562 0.09436266101287792 0.0862181768969702 0.21584173773512197 0.6948960920471136 1.183732369262227e-07 6.926746476406113 9.876870952567915 up VEEEIQTLSQVLAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEEEIQTLSQVLAAK 15 0 P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;H0YC42;E5RFR7;H0YC44;P55327-8 P55327-2 TPD52 Tumor protein D52 0 10841300.0 1432100.0 5493800.0 3915400.0 False True 1877496.9684761267 4674146.454664672 3510271.9671688555 1.0 2.489562717354718 1.8696551984411316 20.84037914760008 -9.936217528224468 5.481231469847925 0.9999982586121893 2.179608957901263 0.8284125181619407 0.25307618485391037 5.385830429135011e-06 1.0445427720018752e-06 0.24504032367447023 0.0816799874367064 1.1581970962747466e-10 9.936217528224468 1.179610699289074 VEEEIQTLSQVLAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEEEIQTLSQVLAAK 15 0 P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;H0YC42;E5RFR7;H0YC44;P55327-8 P55327-2 TPD52 Tumor protein D52 0 19379800.0 11812000.0 2596500.0 4971300.0 False True 11437034.525561912 3633295.990568622 3669167.394196798 1.0 0.317678151836314 0.3208145770650743 23.447209692737946 -10.078119376117957 5.169538187566917 1.0000116759675635 0.31924636444925353 0.9999840796313264 0.001280440242832609 1.7230974008036757e-07 3.073096188947469e-08 0.0012398021711119206 0.00041326031063632594 8.353733645275654e-11 10.078119376117957 -0.6807653115183099 VEEEIQTLSQVLAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEEEIQTLSQVLAAK 15 0 P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;H0YC42;E5RFR7;H0YC44;P55327-8 P55327-2 TPD52 Tumor protein D52 0 13379000.0 1432100.0 4372600.0 7574300.0 False True 1961586.0710473084 4179404.073745435 5785406.337605106 1.0 2.130624873123214 2.9493512535579054 20.90358920912297 -7.787263834631849 0.16618103813157714 4.398002817860952e-16 4.427450222833582 0.9999484425290076 0.005738590237202373 0.1322052345196176 0.023206715169264112 0.2233652043975156 0.32659290411614855 1.6320601673602994e-08 7.787263834631849 4.427450222833582 VEEEIQTLSQVLAAK(ub)EK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEEEIQTLSQVLAAKEK 17 1 P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;H0YC42;E5RFR7;H0YC44;P55327-8 P55327-2 TPD52 Tumor protein D52 1 18688300.0 4499100.0 9601000.0 4588200.0 True False 5898363.669346376 8168568.224404888 4113457.077122173 1.0 1.384887179279348 0.6973895316932879 22.491883345231432 -6.754776035659789 1.6320353871078463 1.2250108303727432 0.6954983223176975 0.6693079983791752 0.1617862650707299 0.29179084108938097 1.5304584478403351 0.07826193723914017 0.18906603366244892 1.7588304036009666e-07 6.754776035659789 -0.5295125080550457 VEEEIQTLSQVLAAKEK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEEEIQTLSQVLAAKEK 17 1 P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;H0YC42;E5RFR7;H0YC44;P55327-8 P55327-2 TPD52 Tumor protein D52 1 70080000.0 36010000.0 20536000.0 13534000.0 True False 54629802.683633946 16871190.351499647 10858998.967837075 1.0 0.3088275908518691 0.19877426668960357 25.703184876413527 -13.999999999999998 0.25861382335005295 6.023356298889174 0.15801322700529288 0.9995595182588094 0.007442626207350956 14.356263617168173 0.16092327737252213 37.65727941924422 0.04846766194745944 1.0000000000000041e-14 13.999999999999998 -5.86534307188388 VEEFLYEK(ub)LDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEEFLYEKLDR 11 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9;H7C1Z6 Q9NR46 SH3GLB2 Endophilin-B2 1 84355000.0 7374000.0 16368000.0 60613000.0 True False 11186897.111611126 13447002.516232297 48632813.98237839 1.0 1.2020314821949474 4.34730144535801 23.4153065984297 -6.919978170241117 0.8248938194038694 0.9305470287328692 4.854241374539345 0.9941747451144777 0.11696820281652161 0.09818460513587296 0.10568253963389516 0.10076834663789223 0.3017837756405618 1.202324867810628e-07 6.919978170241117 3.923694345806476 up VEEFLYEK(ub)LDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEEFLYEKLDR 11 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2;F8WFB9;H7C1Z6 Q9NR46 SH3GLB2 Endophilin-B2 1 72003000.0 7374000.0 0.0 64629000.0 True False 9545788.363270905 0.0 52867185.14953985 1.0 0.0 5.538273334547791 23.18643292052215 -6.86016727527016 1.1847695762948298 0.45713687464202957 5.807474714269386 0.9538514890742168 0.5176988250864614 0.14663588982020828 0.3910016775795177 0.34076572533057553 0.7956630125365476 1.3798526905259548e-07 6.86016727527016 5.350337839627357 up VEEIAASK(ub)CR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEEIAASKCR 10 1 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 1 95966800.0 15487900.0 18454900.0 62024000.0 True False 20304786.88503694 15701500.856636766 55606351.45621943 1.0 0.7732906011541327 2.738583358252187 24.27531654931599 -6.87818103777928 1.0898763267457598 0.8625944422991413 2.8731028007443755 0.9721885269533996 0.146406112935678 0.12925532466826972 0.2821187669094637 0.10364164154773192 0.24951758463262547 1.3237895919953577e-07 6.87818103777928 2.010508358445234 up VEEIAASK(ub)CR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEEIAASKCR 10 1 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 1 41677200.0 11201200.0 11032300.0 19443700.0 True False 10845624.037226893 15437554.92268448 14350811.671503255 1.0 1.4233901958703423 1.323189115005742 23.370609729624803 -10.049450727276522 4.93215402605919 0.9999923477521777 1.3732896554414762 0.9487307289882518 0.040906919977483164 3.4421904900949353e-06 6.633283754716777e-07 0.03960876618778789 0.013202651649756765 8.92378858365559e-11 10.049450727276522 0.3732973076892985 VEEIAASK(ub)CR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEEIAASKCR 10 1 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 1 108873700.0 16511400.0 26843300.0 65519000.0 True False 25049000.94503063 22052903.387339853 52569140.932002105 1.0 0.8803905367617002 2.0986521996371708 24.578249728294992 -6.8827753163747465 1.0642280022801522 0.9227618294385962 2.189709516125142 0.9758548437962307 0.08519574186474939 0.12519883787612138 0.25768638399188537 0.06150658707438847 0.14984135604515958 1.3098594076466378e-07 6.8827753163747465 1.2669476866865457 up VEEIAASK(ub)CR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEEIAASKCR 10 1 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 1 83150600.0 15487900.0 11565700.0 56097000.0 True False 21214195.174759872 11054689.131344654 42848043.95398038 1.0 0.5210986813441432 2.0197817358143255 24.33852661083888 -6.820757389911401 1.3688055217025081 0.7420770439285373 2.0529765329638403 0.8860685464632524 0.2109526489670094 0.1925025192821446 0.7085392899492041 0.12110681136961211 0.2790478141958136 1.5109239664722075e-07 6.820757389911401 1.310899489035303 up VEEIAASK(ub)CR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEEIAASKCR 10 1 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 1 73491900.0 11201200.0 10022700.0 52268000.0 True False 9314294.097296784 9968705.725749819 63196997.14007321 1.0 1.0702588539310736 6.784947574117763 23.15101500505908 -6.909583725815481 0.8985717445183566 0.8207242683915348 7.516920075163801 0.9907633721485175 0.2605126945019694 0.10469374956928615 0.1402677210005367 0.21284725370353955 0.5858688009880274 1.23144855703741e-07 6.909583725815481 6.696195806772266 up VEEIAASK(ub)CR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEEIAASKCR 10 1 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 1 131828700.0 16511400.0 30448300.0 84869000.0 True False 21374332.788352475 28753825.33879316 69423712.82947734 1.0 1.34525019440429 3.2479943826507855 24.34937605038744 -6.937658974905491 0.6809916820932262 0.9775312126703697 3.727599129107 0.9978409510113253 0.04592839720421467 0.08885100038199695 0.059595439757276665 0.043951446926486164 0.16552526645199858 1.1543593503518119e-07 6.937658974905491 2.75006791643663 up VEEIICGLIKGGAAK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEEIICGLIKGGAAK 15 1 X6RM59;Q9H0P0-3;Q9H0P0-2;Q9H0P0-1;Q9H0P0;B9A035;C9K084 X6RM59 NT5C3A 5-nucleotidase;Cytosolic 5-nucleotidase 3A 1 19534100.0 3536700.0 4467400.0 11530000.0 True False 5365432.467403725 3670157.5660444903 9251090.446221478 1.0 0.6840376033696386 1.7242021966400747 22.355263029855518 -6.825199665295051 1.3491053526608745 0.8305299939141607 1.7495682626444558 0.8959522997818338 0.14044797595562666 0.1868089168793455 0.6666099462305298 0.08177393933680412 0.18827789009236248 1.4955479253427374e-07 6.825199665295051 0.919038268730295 VEEIICGLIKGGAAK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEEIICGLIKGGAAK 15 1 X6RM59;Q9H0P0-3;Q9H0P0-2;Q9H0P0-1;Q9H0P0;B9A035;C9K084 X6RM59 NT5C3A 5-nucleotidase;Cytosolic 5-nucleotidase 3A 1 11112200.0 3536700.0 3681200.0 3894300.0 True False 4578327.868779523 3476337.98396513 3185577.3588923384 1.0 0.7593029777685716 0.695794938718869 22.126389351947967 -13.999999999999998 0.1870313553531174 2.277326247149415 0.6488472977817007 0.9994913166813894 0.00295514381783165 12.303863935261413 0.137138922334814 5.722045843171531 0.0447288697922867 1.0000000000000041e-14 13.999999999999998 -1.6284789493677145 VEEIVAK(ub)NAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEEIVAKNAR 10 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 2113440.0 413590.0 606550.0 1093300.0 True False 400460.8118377198 848748.5781164643 806931.9317030457 1.0 2.1194297994391667 2.0150084798560557 18.61130154520173 -10.277764675544773 5.820889275515948 0.9999332915153774 2.0672191396476034 0.992871054987148 0.042629825207809724 3.6909123988766305e-05 4.579548989137724e-06 0.04127869761799033 0.013758716923461546 5.2751562075233914e-11 10.277764675544773 1.067285848132226 VEEIVAK(ub)NAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEEIVAKNAR 10 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 5932900.0 1470200.0 2340100.0 2122600.0 True False 2230400.8860171777 1922490.8717152507 1703067.1796313715 1.0 0.8619485778398513 0.7635699888339513 21.088871608747674 -6.974783788476739 0.08653444444541122 1.306453624481587 0.3165882078013019 0.9999998573115007 3.617325584525012e-05 0.07477841538534079 0.002519206063252241 0.010715888899979013 0.017963508632741865 1.0597812010938383e-07 6.974783788476739 -0.989865416680285 VEEIVAK(ub)NAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEEIVAKNAR 10 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 1872900.0 561000.0 508530.0 803370.0 True False 768416.8604549541 486061.4631161707 613630.5519245103 1.0 0.6325491905895843 0.7985646639262964 19.551529649124642 -10.024683742910732 4.629603847710654 1.0000082341063947 0.7155569272429222 0.7965040879180182 0.06777553322989871 21557080.39894879 23339243.693146046 1540.2442622650597 0.02320136964258385 9.447486001526716e-11 10.024683742910732 -0.28445130686347253 VEEIVAK(ub)NAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEEIVAKNAR 10 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 2844490.0 413590.0 1239700.0 1191200.0 True False 343918.41014364304 1233021.4900388164 1440274.4125134929 1.0 3.5852151372874315 4.187837492944734 18.391706820636006 -9.707128139684508 0.3940254573551395 3.943204200502224e-15 4.268205785856035 0.9985700367095336 0.05228973809204174 1.0334589327242623 0.1686365184641667 1.4973994848616623 0.15501597606669437 1.962781067876964e-10 9.707128139684508 4.268205785856032 VEEIVAK(ub)NAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEEIVAKNAR 10 1 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 1 2451250.0 1470200.0 981050.0 0.0 True False 1903202.881974624 926453.7050877402 0.0 1.0 0.4867866236764625 0.0 20.859997930840123 -7.970260856118586 0.5849183222058586 1.012722521621927 2.9244770828496025e-18 0.9893305861180471 0.042174039069318305 0.11180020499329843 0.16342356369603436 0.04562345889632973 0.07655467060604725 1.0708758974768086e-08 7.970260856118586 -1.012722521621927 VEEK(ub)SIDLIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEEKSIDLIQK 11 1 C9J050;C9JEJ2;P49585 C9J050 PCYT1A Choline-phosphate cytidylyltransferase A 1 2561570.0 668020.0 224750.0 1668800.0 True False 915005.0465617096 214819.8018511382 1274663.8100148418 1.0 0.23477444486056218 1.393067518922013 19.803420174805595 -6.728531086294119 1.7283727495130956 0.5387374168156036 1.3922223583455269 0.5525083417571616 0.3217228152268387 0.33901100079394736 1.9832857418847674 0.14754417640441791 0.36676112275790895 1.868395934860463e-07 6.728531086294119 0.8534849415299233 VEEQEPELTSTPNFVVEVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEEQEPELTSTPNFVVEVIK 20 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 35662300.0 4343200.0 23283000.0 8036100.0 False True 5693977.259608629 19809267.15642318 7204601.45971437 1.0 3.478985997528335 1.2653021133086808 22.44100530063488 -6.618995399671535 2.120437073509576 2.6460304716088237 1.2737001607614837 0.07941321244325406 1.0663220118555707 0.5881155121044239 5.02336423858897 0.41340716131501365 1.1824742357323483 2.404388268710019e-07 6.618995399671535 -1.37233031084734 VEEQEPELTSTPNFVVEVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEEQEPELTSTPNFVVEVIK 20 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 50306900.0 9569100.0 9805800.0 30932000.0 False True 9265334.158360515 13721307.076571452 22829981.259890817 1.0 1.4809295425346445 2.464021358505492 23.143411577947585 -6.9596154769315985 0.4408191358293365 0.9651475299863379 3.018184899193767 0.9997556723199715 0.009523818745755678 0.079838756905765 0.02164097160190706 0.012974784686033318 0.081442780397588 1.0974494446488993e-07 6.9596154769315985 2.0530373692074293 VEEQEPELTSTPNFVVEVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEEQEPELTSTPNFVVEVIK 20 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 48223200.0 4343200.0 25353000.0 18527000.0 False True 5948998.410566772 24232820.628840536 14151304.175542267 1.0 4.073428660830963 2.378770878540888 22.504215362157773 -9.544749766857876 6.477797535756093 1.0000000065014092 3.226099769693153 0.6970358942138326 0.6918411426307189 227553081.93896598 24.254244301633083 2.234302924140699 0.23683562500411925 2.852661449396858e-10 9.544749766857876 2.2260997631917436 VEEQEPELTSTPNFVVEVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEEQEPELTSTPNFVVEVIK 20 0 Q07021;I3L3Q7;I3L3B0 Q07021 C1QBP Complement component 1 Q subcomponent-binding protein, mitochondrial 0 16932500.0 9569100.0 0.0 7363400.0 False True 7957130.63300741 0.0 8903052.89548511 1.0 0.0 1.1188773071732503 22.92381685338186 -10.683591466235605 4.333755165358398 1.0187399864775055 0.5594386535864948 0.1713086825793021 0.45677974789272946 0.0833043174984051 0.0060820645915371134 0.44546938041084627 0.14742502970605242 2.072089613336968e-11 10.683591466235605 -0.4593013328910107 VEESSWLIEDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEESSWLIEDGK 12 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 26328300.0 3606300.0 10584000.0 12138000.0 False True 4727894.223458876 9004908.456108863 10882076.195917564 1.0 1.90463407819665 2.3016750548104175 22.172766327978707 -9.937399964309192 0.20303821294048352 4.88563788072593e-20 2.649891541827593 0.9994036915497857 0.013301459006506283 1.4331642359137435 0.09158285277386446 1.0354796076829702 0.2328682440561605 1.1550480086059892e-10 9.937399964309192 2.649891541827593 VEESSWLIEDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEESSWLIEDGK 12 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 19756600.0 5635700.0 1670900.0 12450000.0 False True 5456797.788326208 2338099.083628387 9188971.508005977 1.0 0.4284745695782076 1.68394942683492 22.379623152308284 -6.782935964286958 1.5243770252938116 0.6776181126335981 1.6948339219758581 0.7776440444705363 0.2420117284310089 0.24604783466151792 1.1294589438862157 0.1250187111993058 0.2942828919093647 1.6484054271606299e-07 6.782935964286958 1.01721580934226 VEESSWLIEDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEESSWLIEDGK 12 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 19678700.0 3606300.0 7544900.0 8527500.0 False True 4939646.566593052 7211541.3703521835 6513480.129375341 1.0 1.4599306393951361 1.3186125852457065 22.235976389501598 -9.979608810233545 4.862904690566807 0.9999960747371469 1.3892716122594806 0.9100471378467465 0.057692854056028565 39680517.433164895 0.018837651405848765 1887.4693293306113 0.019749798477617844 1.0480721716276938e-10 9.979608810233545 0.3892755375223337 VEESSWLIEDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEESSWLIEDGK 12 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 9942000.0 5635700.0 1761700.0 2544600.0 False True 4686334.253842036 1752209.3724299308 3076664.095098923 1.0 0.373897651665244 0.6565182781353157 22.16002842774256 -10.44548372373944 6.13122416703522 1.000193059813335 0.5152079649003298 0.7968806480375807 0.11537938760623294 0.0003046062762912842 2.7548824273792723e-05 0.11175926368318993 0.03723853722454588 3.585223845384556e-11 10.44548372373944 -0.48498509491300523 VEFLECSAK(ub)GGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEFLECSAKGGR 12 1 Q9Y5M8;H7C4H2 Q9Y5M8 SRPRB Signal recognition particle receptor subunit beta 1 5820200.0 1013700.0 1814200.0 2992300.0 True False 1328970.5166847648 1543528.4316962124 2682685.5001684036 1.0 1.1614467080478816 2.018619274459603 20.341877667990556 -6.938476173015586 0.6735974803912308 0.9900778262864561 2.239760033920596 0.9979573358858006 0.020203181219090507 0.08846884442394977 0.05782878378454966 0.019446183008516988 0.07428414777472506 1.1521892714112124e-07 6.938476173015586 1.24968220763414 up VEFLECSAK(ub)GGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEFLECSAKGGR 12 1 Q9Y5M8;H7C4H2 Q9Y5M8 SRPRB Signal recognition particle receptor subunit beta 1 3706680.0 845050.0 843930.0 2017700.0 True False 818224.3503069845 1180915.6500368107 1489203.8402974834 1.0 1.4432663237090784 1.820043414423878 19.642136946818468 -6.973010246449683 0.17167396974007762 0.6745191627550393 2.598896774431154 0.9999973472101279 0.0005458378819840205 0.07533746623357715 0.005364561431314024 0.015636716171275843 0.04341115553666652 1.0641179118512897e-07 6.973010246449683 1.9243776116761149 VEFLECSAK(ub)GGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEFLECSAKGGR 12 1 Q9Y5M8;H7C4H2 Q9Y5M8 SRPRB Signal recognition particle receptor subunit beta 1 5213400.0 1013700.0 1243300.0 2956400.0 True False 1388492.2842124563 1188366.8949567091 2258159.2089692443 1.0 0.8558685622302489 1.6263390402994262 20.405087729513447 -6.858361932522649 1.1941134218073208 0.9221215099761138 1.6624738908356769 0.9516000221302197 0.07357854442473084 0.14850348941625288 0.4033248941950582 0.048091691944988 0.11205202199826655 1.3856006151342082e-07 6.858361932522649 0.7403523808595631 VEFMDDTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEFMDDTSR 9 0 P62857 P62857 RPS28 40S ribosomal protein S28 0 21089110.0 648210.0 9694900.0 10746000.0 False True 849809.5872745697 8248458.710424206 9634107.002910703 1.0 9.706243414925332 11.336783141983977 19.69678009419469 -9.27978159580394 0.57043183228527 1.1521157173451843e-21 11.228053990947156 0.9979246823643366 0.20671227479931775 0.6580031654013146 0.24612240459260662 1.987804705248373 0.2933817888234616 5.250714492755582e-10 9.27978159580394 11.228053990947156 VEFMDDTSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEFMDDTSR 9 0 P62857 P62857 RPS28 40S ribosomal protein S28 0 17047600.0 5021500.0 1476100.0 10550000.0 False True 4862095.231130129 2065514.4277598087 7786638.506784181 1.0 0.4248198214084975 1.601498559084019 22.21314672022551 -6.773778469940937 1.5598449549102649 0.6716834291507824 1.609104638829645 0.7448314860188241 0.24267890709150855 0.2603749666570763 1.25073907841497 0.12258983030233708 0.2908325003536048 1.6835325982784777e-07 6.773778469940937 0.9374212096788627 VEFMDDTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEFMDDTSR 9 0 P62857 P62857 RPS28 40S ribosomal protein S28 0 21004310.0 648210.0 8106100.0 12250000.0 False True 887870.754216589 7747945.698711958 9356802.29666934 1.0 8.726434181907864 10.53847336702209 19.75999015571758 -9.189868018531156 0.5221036796314279 5.731562160844549e-19 10.509495540469983 0.9974965312266714 0.20694696808791446 0.5930497058095353 0.2154004886498671 1.772100214915774 0.3517928606842974 6.458504722443724e-10 9.189868018531156 10.509495540469983 VEFNIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEFNIR 6 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 21409900.0 4093700.0 6872200.0 10444000.0 False True 5366880.343447195 5846894.547625787 9363355.065922137 1.0 1.0894400794242924 1.7446550820449205 22.3556522923821 -6.931772170072588 0.732096899794013 0.9906625400502568 1.8854473194958152 0.996875303528195 0.018556604364207613 0.09172779340439202 0.07324759712715019 0.017087866290534777 0.05871845701234882 1.1701130687741078e-07 6.931772170072588 0.8947847794455585 VEFNIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEFNIR 6 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 9045800.0 2844400.0 1257400.0 4944000.0 False True 2754106.078945846 1759486.3772543755 3649018.083179243 1.0 0.6388593346875846 1.3249373766227375 21.39315269765028 -6.763709964195563 1.5987975757533206 0.7911967435611437 1.3278881911760265 0.7058202405294651 0.1519867557802868 0.2767279561915523 1.3949575508036987 0.07498160086352472 0.17951766241635134 1.723018878188299e-07 6.763709964195563 0.5366914476148829 VEFNIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEFNIR 6 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 20153500.0 4093700.0 7161600.0 8898200.0 False True 5607251.518082799 6845176.831755777 6796628.4241814865 1.0 1.220772210713359 1.2121140637731465 22.41886235390499 -10.334204782916212 5.544758154834497 0.9999559802965258 1.2164431372432138 0.998801318527036 0.003534673686937002 1.9239453011046956e-06 2.3101692188245543e-07 0.003423128055218769 0.001140811026980544 4.632284420818785e-11 10.334204782916212 0.21648715694668808 VEFNIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEFNIR 6 0 Q8NC51;Q8NC51-2;Q8NC51-3;Q8NC51-4 Q8NC51;Q8NC51-3 SERBP1 Plasminogen activator inhibitor 1 RNA-binding protein 0 6429600.0 2844400.0 2206500.0 1378700.0 False True 2365244.628285452 2194613.14654404 1666979.7956114437 1.0 0.9278588439855792 0.7047811358184227 21.173557973084556 -6.950768620735114 0.5503491380105805 1.0030787359857927 0.6190752595156371 0.9992601720231692 0.0034180187741340395 0.0831787309742718 0.034697549174553005 0.0037081736654909106 0.018507374596386718 1.1200344457890447e-07 6.950768620735114 -0.38400347647015554 VEGDLK(ub)GPEVDIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEGDLKGPEVDIR 13 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 4746700.0 2544700.0 2202000.0 0.0 True False 2116030.799324278 2190137.3889372223 0.0 1.0 1.035021508021816 0.0 21.01292919569342 -6.998575098376909 1.1240165097675836 1.0336424341347608 8.090019932629598e-20 0.9829588779280007 0.06264330904552602 0.09231983538430413 0.22839618797079186 0.046916453614921805 0.0861265035592081 1.0032863454677462e-07 6.998575098376909 -1.0336424341347608 down VEGFPTIYFAPSGDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEGFPTIYFAPSGDK 15 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 36064200.0 6535200.0 12627000.0 16902000.0 False True 8567710.48696682 10743100.819660492 15153143.175432405 1.0 1.2539056771354342 1.7686338956578105 23.03047829987055 -6.959779842979588 0.438532666597431 0.9813113845981895 2.0612476286080614 0.9997619274862107 0.004933746794112495 0.07977995925295801 0.021423275657351182 0.0067742201174807596 0.04266045458566909 1.0970341750442067e-07 6.959779842979588 1.0799362440098719 VEGFPTIYFAPSGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEGFPTIYFAPSGDK 15 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 25465600.0 7814900.0 4400700.0 13250000.0 False True 7566820.27715998 6157922.4593473235 9779427.508520419 1.0 0.8138058304271697 1.292409116420945 22.85125574878377 -6.8011882834102675 1.4509360560355882 0.8974241205216008 1.2992213093296516 0.8356609195804285 0.07985580197690592 0.2190565577102483 0.9102999593295796 0.04329431986411852 0.1006200448936002 1.580562655831523e-07 6.8011882834102675 0.4017971888080508 VEGFPTIYFAPSGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEGFPTIYFAPSGDK 15 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 30825200.0 6535200.0 11788000.0 12502000.0 False True 8951440.047139425 11267167.182296854 9549285.086772267 1.0 1.2586988376130002 1.0667875823872488 23.09368836139344 -10.466199188365662 3.615497293786818 0.9981055779773319 1.1627432099957136 0.48949230786468356 0.078347442609575 56513942.36475853 2113.9452277460027 899575.5060641613 0.02682039324218491 3.418226302347195e-11 10.466199188365662 0.16463763201838166 VEGFPTIYFAPSGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEGFPTIYFAPSGDK 15 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 15930600.0 7814900.0 4694200.0 3421500.0 False True 6498435.608770898 4668911.412874257 4136919.8307714188 1.0 0.7184669809719522 0.6366024193865742 22.631661024218047 -13.999999999999998 0.17318376237321415 2.4320000901503627 0.5667827820315564 0.9995079646119237 0.003452430324380144 12.124088433176318 0.13183973740143304 5.834730511481651 0.06485693695367051 1.0000000000000041e-14 13.999999999999998 -1.8652173081188064 VEGFPTIYFAPSGDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEGFPTIYFAPSGDKK 16 1 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 25260200.0 5007700.0 9178500.0 11074000.0 False True 6565143.194635789 7809103.577512785 9928168.709308876 1.0 1.1894795507116134 1.5122547086895117 22.64639504791194 -6.963057328138052 0.38995910444083415 0.9801672925103857 1.7331638450202842 0.9998673294318413 0.0024358077557274076 0.07862652004803453 0.017223948270456813 0.004167486315261688 0.027151737676705635 1.0887863608724588e-07 6.963057328138052 0.7529965525098985 VEGFPTIYFAPSGDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEGFPTIYFAPSGDKK 16 1 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 19379600.0 7619900.0 2739700.0 9020000.0 False True 7378010.4454223905 3833676.4973467626 6657391.405800303 1.0 0.5196084399318419 0.902328812766972 22.814800400854658 -9.903165195273873 6.648513442915229 1.0000000147442958 0.7109686263494003 0.4319605277038283 0.15624493793566036 3.4145147481226585e-08 5.425093034699439e-09 0.15128351965568682 0.05042783687949814 1.249783551906024e-10 9.903165195273873 -0.2890313883948955 VEGFPTIYFAPSGDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEGFPTIYFAPSGDKK 16 1 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 24074800.0 5007700.0 9700500.0 9366600.0 False True 6859182.018004064 9271899.834736213 7154401.9911823 1.0 1.3517500790034755 1.0430401135883753 22.709605109434833 -10.202603071959878 5.093713802888088 0.9999828752349917 1.197395096296065 0.3528105619595576 0.12603031563035919 2.451168053020744e-05 3.837150399016636e-06 0.12203891082786254 0.04067610946273404 6.271868268411871e-11 10.202603071959878 0.19741222106107337 VEGFPTIYFAPSGDKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEGFPTIYFAPSGDKK 16 1 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 14971900.0 7619900.0 3269100.0 4082900.0 False True 6336284.468806185 3251488.709434457 4936615.512803339 1.0 0.5131538404630794 0.779102569827242 22.595205676288934 -10.094763985067338 5.2895371557319075 1.0000057619092404 0.6461282051448186 0.7024400526567129 0.10857311411515669 7.377586661235624e-06 1.2628207311500745e-06 0.10512717579828725 0.03504182190098337 8.039629126846808e-11 10.094763985067338 -0.3538775567644218 VEGGVK(ub)GGQIGLQAPGLSVSGPQGHLESGSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEGGVKGGQIGLQAPGLSVSGPQGHLESGSGK 32 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 8251800.0 2947000.0 3718400.0 1586400.0 True False 2450561.07423612 3698368.241155386 1918108.9053151512 1.0 1.5091924376168537 0.7827223428467528 21.22468067216227 -6.7183027186514295 1.7654367054032776 1.310347318640019 0.7839626655405674 0.5044840475214301 0.21431593058186937 0.35862837963543376 2.1835444387749217 0.09642468143281681 0.24254529357036855 1.9129220856936795e-07 6.7183027186514295 -0.5263846530994516 VEGHVFPEFK(ub)ESDAMFAAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEGHVFPEFKESDAMFAAER 20 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 9261700.0 2185900.0 5599000.0 1476800.0 True False 1817672.7017891854 5568837.075685519 1785592.0520482939 1.0 3.0637182756851433 0.9823507005913036 20.793661014172184 -6.648139380133867 2.015355657913928 2.3411198967770144 0.9911190375217723 0.18650803391018755 0.881222792488103 0.5130770428366189 3.992356013512336 0.3548939577788649 0.9758832806379836 2.2483329221666982e-07 6.648139380133867 -1.3500008592552422 VEGK(ub)LLDDPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEGKLLDDPSK 11 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925;Q6STE5-2;Q6STE5 J3KMX2 SMARCD2;SMARCD3 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 1 6717230.0 839750.0 3195170.0 2682310.0 True False 1100920.3821505685 2718463.0906751137 2404770.291734357 1.0 2.469264021949337 2.184327160004806 20.07027870722746 -10.104122680440172 4.691690681263944 0.9999247974398467 2.3267955908821185 0.9665664705230275 0.11632498694119973 40502647.476299606 6.026655389482391 36362.219882618665 0.03982113706803004 7.868234947047809e-11 10.104122680440172 1.3268707934422719 VEGK(ub)LLDDPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEGKLLDDPSK 11 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925;Q6STE5-2;Q6STE5 J3KMX2 SMARCD2;SMARCD3 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 1 10812450.0 4378900.0 3148550.0 3285000.0 True False 4239894.21638868 4405782.434471337 2424559.9521124177 1.0 1.0391255558785975 0.571844444311993 22.015596839915652 -6.886565836413882 1.0424618145502473 1.0272131844541768 0.5342541539739181 0.9786084897821863 0.030957046640718817 0.12197465725898497 0.2384670236608517 0.022722246796931207 0.05599110280377786 1.2984767077015958e-07 6.886565836413882 -0.4929590304802587 VEGK(ub)LLDDPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEGKLLDDPSK 11 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925;Q6STE5-2;Q6STE5 J3KMX2 SMARCD2;SMARCD3 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 1 22298900.0 5975700.0 4983800.0 11339400.0 True False 9065573.782188036 4094401.9513928713 9098162.619764429 1.0 0.4516428909814311 1.003594790397098 23.111966903857333 -10.92732954869259 10.437193708387984 1.047500861413854 0.7276188406893592 0.24511555669702123 0.22533341935472812 0.1271504479671112 0.0008853019153806482 0.11138234921142791 0.07272604837540282 1.182144187850822e-11 10.92732954869259 -0.3198820207244947 VEGK(ub)LLDDPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEGKLLDDPSK 11 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925;Q6STE5-2;Q6STE5 J3KMX2 SMARCD2;SMARCD3 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 1 5012950.0 839750.0 2023500.0 2149700.0 True False 1150228.268390461 1934095.0791803238 1641985.1344612304 1.0 1.6814880422707261 1.4275298039396085 20.13348876875035 -10.421315326298512 5.582743441592244 0.9996739678170098 1.5545089231051692 0.8640693487620899 0.10367801664789995 0.00042096322955414886 4.36352759647694e-05 0.1004430507726341 0.0334619359870933 3.790396773562809e-11 10.421315326298512 0.5548349552881594 VEGK(ub)LLDDPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEGKLLDDPSK 11 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925;Q6STE5-2;Q6STE5 J3KMX2 SMARCD2;SMARCD3 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 1 14252620.0 4378900.0 6734300.0 3139420.0 True False 3641249.368161708 6698020.9892461095 3795858.2069619847 1.0 1.8394842846557413 1.0424603819096112 21.79600211534993 -10.373704639257012 4.199188711241713 0.9989660991588432 1.4409723332884812 0.28984787475938334 0.32538364577438483 0.0031565632746231058 0.00047079032403478377 0.3157578616869189 0.10501712009834677 4.2295616610450485e-11 10.373704639257012 0.442006234129638 VEGK(ub)LLDDPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEGKLLDDPSK 11 1 J3KMX2;B9EGA3;Q92925-3;Q92925-2;Q92925;Q6STE5-2;Q6STE5 J3KMX2 SMARCD2;SMARCD3 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2;SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 1 36429200.0 5975700.0 3363200.0 27090300.0 True False 7735661.448657163 3176034.9635096 22160143.36995123 1.0 0.4105705742927684 2.86467337241058 22.883093225949782 -6.843284937705053 1.2669049210503753 0.6864171456756764 2.9508539275521493 0.9299669035283638 0.27681114879897034 0.16500714375253547 0.5130139276614469 0.17121771792079532 0.3949029850888676 1.434547927228571e-07 6.843284937705053 2.264436781876473 up VEGSLAVSRALGDFTYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEGSLAVSRALGDFTYK 17 1 H7C347;Q8N819-2;Q8N819 H7C347 PPM1N Probable protein phosphatase 1N 0 32225200.0 14247000.0 11237000.0 6741200.0 False True 13794736.78341351 15723992.700180853 4975477.488334921 1.0 1.1398544928444765 0.3606794074039402 23.717614593183484 -6.860469257392407 1.1832590671997303 1.0759831580366364 0.32258989784435715 0.9542151108334656 0.072576284093716 0.14632461780480713 0.3890083062341981 0.047827460760258296 0.11171085701035507 1.378893557900526e-07 6.860469257392407 -0.7533932601922793 down VEGSLAVSRALGDFTYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEGSLAVSRALGDFTYK 17 1 H7C347;Q8N819-2;Q8N819 H7C347 PPM1N Probable protein phosphatase 1N 0 45808400.0 14247000.0 8189400.0 23372000.0 False True 11847011.749115022 8145282.076731369 28258977.140081737 1.0 0.687538954904795 2.385325324100628 23.49801986861776 -6.859216382237034 1.1898371889578847 0.8308275512668647 2.4662555107706328 0.9526598997775952 0.16053049442228365 0.14761710306342532 0.39757752867524654 0.1052673902780762 0.24548878652600353 1.382877204616815e-07 6.859216382237034 1.635427959503768 up VEGTEPTTAFNLFVGNLNFNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEGTEPTTAFNLFVGNLNFNK 21 0 P19338 P19338 NCL Nucleolin 0 494554000.0 256650000.0 83644000.0 154260000.0 False True 248502786.2331074 117043485.39769758 113854678.29919682 1.0 0.4709946603492214 0.4581625825007682 27.888686786589286 VEGTEPTTAFNLFVGNLNFNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEGTEPTTAFNLFVGNLNFNK 21 0 P19338 P19338 NCL Nucleolin 0 361152000.0 75432000.0 159340000.0 126380000.0 False True 114435858.81788035 130904532.07089768 101400937.60567819 1.0 1.1439118246949718 0.8860940849585734 26.76996395485579 -6.755210344692843 1.6301846614300144 1.0840916286701063 0.8853605709065723 0.6711293171425357 0.06049618436110787 0.29109529068234113 1.5234249685949786 0.02929419420069086 0.07074434072390598 1.757072393448327e-07 6.755210344692843 -0.19873105776353406 VEGTEPTTAFNLFVGNLNFNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEGTEPTTAFNLFVGNLNFNK 21 0 P19338 P19338 NCL Nucleolin 0 398086000.0 256650000.0 76442000.0 64994000.0 False True 213415846.52280292 76030191.77345099 78583944.90169741 1.0 0.3562537319145482 0.3682198214522038 27.669092062023562 -9.955621056017192 5.234358333307466 1.0000020059804466 0.36223677667971266 0.9997360432483431 0.0048851356133984055 3520171.7450337163 3347638.7579577714 74.8568320549524 0.001672312146334017 1.107589790791637e-10 9.955621056017192 -0.637765229300734 VEGTEPTTAFNLFVGNLNFNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEGTEPTTAFNLFVGNLNFNK 21 0 P19338 P19338 NCL Nucleolin 0 203227000.0 75432000.0 60958000.0 66837000.0 False True 97648210.98701523 57565633.713611506 54673351.80553302 1.0 0.5895206182657693 0.5599012132726446 26.54109027694824 -13.999999999999998 0.3731429059712378 6.831883112112158 0.5569806157863062 0.999796231244332 0.0028670443581261945 23.191033439216678 0.19855613466132652 108.33069437535879 0.008197228023218628 1.0000000000000041e-14 13.999999999999998 -6.274902496325852 VEGTEPTTAFNLFVGNLNFNK(ub)SAPELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEGTEPTTAFNLFVGNLNFNKSAPELK 27 1 P19338 P19338 NCL Nucleolin 1 22283900.0 10495000.0 6672800.0 5116100.0 True False 10161841.969672564 9337283.838192292 3776039.930289904 1.0 0.9188574144391224 0.37159010556937205 23.27665859778351 -6.933413280360281 0.7182236970133071 1.0073609150733243 0.24880691248177128 0.9971675536326502 0.014852987155261314 0.09090392462279505 0.06927943507890919 0.01381778479808296 0.0486223962606082 1.165699793776197e-07 6.933413280360281 -0.7585540025915529 down VEGTEPTTAFNLFVGNLNFNK(ub)SAPELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEGTEPTTAFNLFVGNLNFNKSAPELK 27 1 P19338 P19338 NCL Nucleolin 1 21375400.0 10495000.0 5120400.0 5760000.0 True False 8727057.507332236 5092815.388880171 6964389.36876908 1.0 0.5835661544113038 0.7980226282361255 23.057063873217785 -10.085898432033982 4.853993293976087 1.000011303278381 0.69079439132097 0.7348715667442187 0.08755148882735947 1.0709966427296114e-05 2.0169891366038137e-06 0.08477446182984927 0.02825712151232089 8.205434214665421e-11 10.085898432033982 -0.3092169119574111 VEGTEPTTAFNLFVGNLNFNK(ub)SAPELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEGTEPTTAFNLFVGNLNFNKSAPELK 27 1 P19338 P19338 NCL Nucleolin 1 39988700.0 11596000.0 9645700.0 18747000.0 True False 15011250.591332968 9108908.31574824 15335238.360463917 1.0 0.6068054263918186 1.0215829965104979 23.83954083748973 -11.017057240400336 12.720935701918641 1.3062268811002502 0.8141942114326733 0.21108481989379446 0.16933223392370592 0.0488277681232716 6.547218052446294e-05 0.005443635989558564 0.054651743496884314 9.614855453790513e-12 11.017057240400336 -0.49203266966757686 VEGTLK(ub)GPEVDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEGTLKGPEVDLK 13 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 6941600.0 3304000.0 2174300.0 1463300.0 True False 2747422.3920176937 2162586.6143352417 1769269.2644652426 1.0 0.7871329216135013 0.6439742464084308 21.389647298457714 -8.07610184451923 0.07936676147060549 1.5859545471036156 6.538965570675134e-05 0.9999955363048539 0.00030898295744986745 0.09804127844871374 0.013876290311747802 0.12946910446113366 0.139297709742993 8.392631514716957e-09 8.07610184451923 -1.5858891574479088 VEGTLK(ub)GPEVDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEGTLKGPEVDLK 13 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 5401100.0 0.0 3271300.0 2129800.0 True False 0.0 3089249.2792961868 1742198.2535934327 0.0 VEHSDLSFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEHSDLSFSK 10 0 P61769;F5H6I0;H0YLF3 P61769 B2M Beta-2-microglobulin;Beta-2-microglobulin form pI 5.3 0 8132580.0 521080.0 4490900.0 3120600.0 False True 683140.9261458982 3820875.225391088 2797710.2469089106 1.0 5.593099577487567 4.095363254977062 19.38182369933499 -10.334274078373744 6.8345379979969945 0.9998916371506994 4.844231416232315 0.8977912009328126 0.6114482932305464 0.0010096277784675158 9.834554977092533e-05 0.592047217776776 0.19734408806240455 4.631545358559824e-11 10.334274078373744 3.844339779081616 VEHSDLSFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEHSDLSFSK 10 0 P61769;F5H6I0;H0YLF3 P61769 B2M Beta-2-microglobulin;Beta-2-microglobulin form pI 5.3 0 8827730.0 3083900.0 1283030.0 4460800.0 False True 2986003.2825415167 1795350.5699130595 3292382.6588685177 1.0 0.6012553905784588 1.1026051706367277 21.50978432076574 -6.694823916643501 1.8495345206030278 0.7511496944614092 1.1009685788586294 0.39300981429497883 0.16847948045489042 0.4063625857087735 2.6987652562882003 0.07277799911904052 0.18835661057922776 2.019184870009813e-07 6.694823916643501 0.3498188843972202 VEHSDLSFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEHSDLSFSK 10 0 P61769;F5H6I0;H0YLF3 P61769 B2M Beta-2-microglobulin;Beta-2-microglobulin form pI 5.3 0 13590780.0 521080.0 4983800.0 8085900.0 False True 713737.3576575186 4763599.2367773205 6176176.954337849 1.0 6.674162681369828 8.653290861232236 19.445033760857882 -8.988524625806427 0.4295415351254613 2.3866139697368538e-23 8.897328544358949 0.9972423720615273 0.17032927906716971 0.4564482909067109 0.1598347703222337 1.3448860639268247 0.46147475290376166 1.0267752087675547e-09 8.988524625806427 8.897328544358949 VEIAGPGFINVHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEIAGPGFINVHLR 14 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 54346000.0 18711000.0 17570000.0 18065000.0 False True 24530302.197581753 14948624.487323593 16195807.091716161 1.0 0.6093942246173086 0.6602367537613448 24.54806167129364 -10.09155022069972 6.552905707434987 1.000000406918281 0.6348154891897533 0.9856707727301334 0.020756375605914857 1.2339138386107504e-07 1.7114969965548988e-08 0.020097296572295125 0.006699091420777413 8.099342775429183e-11 10.09155022069972 -0.3651849177285278 VEIAGPGFINVHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEIAGPGFINVHLR 14 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 54101000.0 21379000.0 17148000.0 15574000.0 False True 20700335.34727297 23995285.825638674 11494702.190014862 1.0 1.1591737729408222 0.5552906268027757 24.303150803913375 -6.836633683809654 1.2979151345584596 1.0847475204077404 0.5367130578261666 0.9185159180490732 0.07294938539967873 0.17276525738194445 0.5667882228523952 0.04409492651277903 0.10151411709631797 1.456687240652298e-07 6.836633683809654 -0.5480344625815737 VEIAGPGFINVHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEIAGPGFINVHLR 14 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 123652000.0 39252000.0 44406000.0 39994000.0 False True 59548153.70558183 36481402.354338445 32089168.370007053 1.0 0.6126370018911067 0.5388776372255372 25.82755344213982 -13.999999999999998 0.23321361106592792 3.4822382253838047 0.5040944341450582 0.9995143466465466 0.00445696128102056 13.3934789197503 0.15288506327545576 15.422553014963741 0.03753678228412303 1.0000000000000041e-14 13.999999999999998 -2.9781437912387467 VEIAGPGFINVHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEIAGPGFINVHLR 14 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 91627000.0 18711000.0 25579000.0 47337000.0 False True 25628962.345762316 24448835.20155848 36156975.53611733 1.0 0.9539533778901131 1.4107857761980673 24.611271732816533 -6.882082369335639 1.068155498385482 0.9705959105663349 1.4444773176899233 0.9753251008464887 0.032258730453378855 0.12579977570568307 0.2612957954613546 0.023219402659730812 0.05645780382088391 1.3119510476309737e-07 6.882082369335639 0.4738814071235884 VEIAGPGFINVHLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEIAGPGFINVHLR 14 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 40077500.0 21379000.0 7918500.0 10780000.0 False True 17777585.750286415 7875841.468800808 13034048.158911563 1.0 0.44302086793050177 0.7331731283423325 24.08355607934765 -10.04231572989511 5.127973553874186 1.0000049319711728 0.5880969981360382 0.728780909772871 0.11845416429303672 6.8472358486255905e-06 1.278829845047443e-06 0.11469415839170234 0.03823091713217122 9.071607890806175e-11 10.04231572989511 -0.4119079338351346 VEIAGPGFINVHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEIAGPGFINVHLR 14 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 111566000.0 39252000.0 48037000.0 24277000.0 False True 50812487.77259425 45363698.72208327 19858835.10305555 1.0 0.8927667333491632 0.3908258771334244 25.59867976423227 -6.941287376842195 0.6474817874923688 1.0055328349657675 0.2501859692215248 0.9983276348553515 0.01085856945222966 0.08718435487921429 0.05197289826762399 0.010676052918382967 0.04296197106043997 1.144755195229193e-07 6.941287376842195 -0.7553468657442427 down VEIATLTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEIATLTR 8 0 P25789;H0YN18;H0YMZ1;H0YL69;P25789-2 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type 0 10847230.0 880230.0 3704300.0 6262700.0 False True 1153990.0541594466 3151632.879248305 5614695.880060383 1.0 2.731074559861713 4.865462973292317 20.13819935927232 -6.968309785587609 0.29578385691989195 0.6107795989612828 7.052239138738311 0.9999660343212801 0.009213666991396087 0.07685503716333644 0.010982767738167592 0.03617210833090282 0.19229699586730137 1.0756976365218165e-07 6.968309785587609 6.4414595397770285 VEIEK(ub)SLTQMEDVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEIEKSLTQMEDVLK 15 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 5131200.0 0.0 5131200.0 0.0 True False 0.0 7180114.918854503 0.0 0.0 VEIEK(ub)SLTQMEDVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEIEKSLTQMEDVLK 15 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 7356200.0 0.0 3853200.0 3503000.0 True False 0.0 3832442.0467996863 4235461.103957998 0.0 VEIEK(ub)SLTQMEDVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEIEKSLTQMEDVLK 15 1 Q9NYP9 Q9NYP9 MIS18A Protein Mis18-alpha 1 27489600.0 5721200.0 8436400.0 13332000.0 True False 7406206.181712158 7966906.923808382 10905712.797871925 1.0 1.075706877224231 1.4725100179901762 22.820303282645916 -6.938759638338074 0.6710056328936328 0.9954361289387502 1.5757197972724082 0.9979968609733323 0.009274293858476236 0.08833708680441175 0.05722130317312133 0.008945141852693832 0.03434289475202634 1.1514374793624682e-07 6.938759638338074 0.580283668333658 VEILANDQGNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEILANDQGNR 11 0 P17066;P48741 P17066 HSPA6;HSPA7 Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 275639000.0 37839000.0 134340000.0 103460000.0 False True 49607295.43339728 114296995.65321872 92754951.65839769 1.0 2.304036022416779 1.8697844913341513 25.56404896852563 -10.161390761721139 4.906926493298396 0.9999165935196086 2.0869102568786477 0.8930826339944309 0.17728244520679728 0.0001617743845810851 2.764711420213126e-05 0.1716660038827233 0.05721766315350225 6.896190315307501e-11 10.161390761721139 1.0869936633590391 VEILANDQGNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEILANDQGNR 11 0 P17066;P48741 P17066 HSPA6;HSPA7 Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 251292000.0 64133000.0 27619000.0 159540000.0 False True 62097133.01962937 38647410.73118234 117751687.90259212 1.0 0.6223702907341246 1.896249990565103 25.888023325993142 -6.827292054820966 1.3400112227348868 0.797813567917798 1.9286613623800204 0.9003427258463738 0.16864935169488515 0.18417515771049006 0.6477367338097866 0.09884555220021086 0.22750714867309893 1.488359847261192e-07 6.827292054820966 1.1308477944622224 VEILANDQGNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEILANDQGNR 11 0 P17066;P48741 P17066 HSPA6;HSPA7 Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 1032958300.0 9830300.0 999620000.0 23508000.0 False True 14913283.791194849 821230000.9332913 18861633.496077582 1.0 55.06701357203198 1.264753877158425 23.830094627242158 -9.800545094229847 6.905388501778623 1.0000000127180324 28.165883724596323 0.253690562894338 21.964680543529013 4.759794838471496e-05 8.811376695761593e-06 21.26721080425763 7.089070162487221 1.5829051999004645e-10 9.800545094229847 27.16588371187829 VEILANDQGNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEILANDQGNR 11 0 P17066;P48741 P17066 HSPA6;HSPA7 Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 260377000.0 37839000.0 97508000.0 125030000.0 False True 51829100.86052594 93199774.14416358 95500489.07367899 1.0 1.7982132160649993 1.842603623988662 25.62725903004852 -11.151938196825832 0.49632396889576186 1.0234126692689824e-19 1.8407839077878956 0.9998058799519104 0.005394299716612796 3.174639740467482 0.2423962287328483 3.553849583777618 0.009090402193992245 7.047933589071218e-12 11.151938196825832 1.8407839077878956 VEILANDQGNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEILANDQGNR 11 0 P17066;P48741 P17066 HSPA6;HSPA7 Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 97234000.0 64133000.0 19645000.0 13456000.0 False True 53329431.07362915 19539168.485772792 16269587.386485528 1.0 0.36638621662391424 0.3050770851844071 25.66842860142742 -13.999999999999998 0.33026161953443844 7.908189112255033 0.29425250831621846 0.9997153848123108 0.005299672037759189 18.845298014379065 0.18378235155259512 90.44078526127814 0.019627443823179883 1.0000000000000041e-14 13.999999999999998 -7.613936603938814 VEILANDQGNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEILANDQGNR 11 0 P17066;P48741 P17066 HSPA6;HSPA7 Heat shock 70 kDa protein 6;Putative heat shock 70 kDa protein 7 0 48985300.0 9830300.0 39155000.0 0.0 False True 12725517.134182526 36975989.829988785 0.0 1.0 2.9056571485543863 0.0 23.601220949334607 -6.729843268077355 1.7239951827782354 2.1471359430741304 0.0019414580617877928 0.558209817282401 0.8011193193267581 0.33666520676755346 1.9602797883054337 0.36826533068994133 0.9139200883057864 1.862759263935852e-07 6.729843268077355 -2.1451944850123428 VEITYTPSDGTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEITYTPSDGTQK 13 0 O75874 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 5846900.0 1103200.0 2302200.0 2441500.0 False True 1446305.8834039983 1958720.7339053145 2188877.000521725 1.0 1.3542921704054098 1.5134260502142363 20.46394127361958 -11.917598895233711 0.1329117272240504 3.88684282671527e-17 1.756082245214959 0.9996933337353148 0.003757930950625266 5.2948410146288065 0.091779693717909 1.6709673878864406 0.18487447583888014 1.2089298605073975e-12 11.917598895233711 1.756082245214959 VEITYTPSDGTQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEITYTPSDGTQK 13 0 O75874 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 3586300.0 1638700.0 0.0 1947600.0 False True 1586680.3654790313 0.0 1437465.1332524049 1.0 0.0 0.905957598346169 20.597580097886247 -9.211748807258775 13.141372910218275 1.000003806630037 0.4529787992610386 0.3271006558744446 0.3698556407641003 0.0 0.0 0.3581111842921079 0.11937039476403595 6.141171032876098e-10 9.211748807258775 -0.5470250073689984 VEITYTPSDGTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEITYTPSDGTQK 13 0 O75874 O75874 IDH1 Isocitrate dehydrogenase [NADP] cytoplasmic 0 4790900.0 1103200.0 1470200.0 2217500.0 False True 1511082.852859014 1405241.7026987462 1693772.170846064 1.0 0.9299567525632277 1.120899603646085 20.52715133514247 -6.807450383854096 1.4255162688584986 0.9617105118557485 1.1240394525571122 0.8529841790661612 0.030240206972214127 0.210304547055046 0.8427991342764152 0.01668364861108797 0.03863399318519531 1.5579360116844945e-07 6.807450383854096 0.16232894070136372 VEIVQK(ub)HNTAAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEIVQKHNTAAR 12 1 H0Y4W2;F2Z2U4;Q9Y4A5-2;Q9Y4A5;A0A2R8YFJ4 H0Y4W2 TRRAP Transformation/transcription domain-associated protein 1 1318470.0 304350.0 312470.0 701650.0 True False 393987.0746354084 295080.76981679484 573956.899536967 1.0 0.7489605340222381 1.456791190594516 18.587788775018787 -6.810835911025804 1.4110554274182217 0.8633215465805526 1.469408249698342 0.8619920986944121 0.10885216923876546 0.20566136753715497 0.8069123416576166 0.060655332061669245 0.14025330610824496 1.545838391519033e-07 6.810835911025804 0.6060867031177894 VEIYSGQK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEIYSGQKK 9 1 Q9H900-2;Q9H900;H3BQ07 Q9H900-2 ZWILCH Protein zwilch homolog 1 2768760.0 676790.0 908070.0 1183900.0 True False 876117.9965253756 857535.1062423172 968442.3478398266 1.0 0.9787895119644193 1.1053789006510573 19.74076566108735 -6.863815611175667 1.1662314022599696 0.9883522477315092 1.1119733280384239 0.9581160685959662 0.01132909909678045 0.14292694757538607 0.36723292568879956 0.007563741425314541 0.017739889232667064 1.36830964682511e-07 6.863815611175667 0.12362108030691465 VEK(ub)APQETYADIGGLDNQIQEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEKAPQETYADIGGLDNQIQEIK 23 1 P62191;P62191-2;G3V4X1 P62191 PSMC1 26S protease regulatory subunit 4 1 9095400.0 2432900.0 4439000.0 2223500.0 True False 3189555.460237118 3776718.503086478 1993433.5493180647 1.0 1.1840893034058448 0.6249878938207486 21.60492393375259 -6.818007246502065 1.3806734019836295 1.0994249558765197 0.6133147440774872 0.8796981970126068 0.08069220925972057 0.19608179586265392 0.7350270593009542 0.045935439508036836 0.10592395988628849 1.5205221585630555e-07 6.818007246502065 -0.48611021179903247 VEK(ub)APQETYADIGGLDNQIQEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEKAPQETYADIGGLDNQIQEIK 23 1 P62191;P62191-2;G3V4X1 P62191 PSMC1 26S protease regulatory subunit 4 1 19246900.0 8080800.0 4897800.0 6268300.0 True False 7824279.427206287 6853517.081689586 4626444.185030827 1.0 0.8759294891563811 0.5912933233115284 22.89952646326543 -6.957276114340856 0.47226625519369847 1.0073548235448693 0.44815480371022537 0.9996554276948564 0.0031759179966042244 0.08068898706665248 0.02483899517680637 0.0039525107519590985 0.023488971838024685 1.1033768954622507e-07 6.957276114340856 -0.5592000198346438 VEK(ub)APQETYADIGGLDNQIQEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEKAPQETYADIGGLDNQIQEIK 23 1 P62191;P62191-2;G3V4X1 P62191 PSMC1 26S protease regulatory subunit 4 1 56590000.0 18001000.0 12889000.0 25700000.0 True False 27308833.0493778 10588857.247783367 20620383.735289864 1.0 0.38774477212692987 0.7550811013420318 24.70286433093848 -10.491425928457657 5.925079354683262 1.0004156208500559 0.5714129367345501 0.6447667838252245 0.14996442842733645 0.0008241162149838378 7.073708677271534e-05 0.14533854410904773 0.04840081115188229 3.2253293717782196e-11 10.491425928457657 -0.4290026841155058 VEK(ub)APQETYADIGGLDNQIQEIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEKAPQETYADIGGLDNQIQEIK 23 1 P62191;P62191-2;G3V4X1 P62191 PSMC1 26S protease regulatory subunit 4 1 17492000.0 8080800.0 6087500.0 3323700.0 True False 6719543.240138186 6054705.429225856 4018670.302947527 1.0 0.9010590769115049 0.5980570641978462 22.679931738699707 -6.950986410897874 0.5479062672015234 1.004243376412634 0.48068916607367373 0.9992764431939491 0.004599628108852658 0.0830920304158251 0.03434153604227525 0.00500586560339867 0.02512681703462055 1.1194729112981577e-07 6.950986410897874 -0.5235542103389602 VEK(ub)APQETYADIGGLDNQIQEIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEKAPQETYADIGGLDNQIQEIK 23 1 P62191;P62191-2;G3V4X1 P62191 PSMC1 26S protease regulatory subunit 4 1 75253300.0 18001000.0 9559300.0 47693000.0 True False 23302649.35275828 9027316.551699957 39013363.37150509 1.0 0.3873944294935466 1.6742029106182799 24.473990653030928 -6.777229123386344 1.5464540142184866 0.6518774593458739 1.6835634515957547 0.7575323856531906 0.25878014445222497 0.2549036658592695 1.2038529859330829 0.1318194639251884 0.3117942407006409 1.6702092193738296e-07 6.777229123386344 1.031685992249881 VEK(ub)TGHSGTLDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEKTGHSGTLDPK 13 1 O60832;O60832-2;C9IYT0;H7C0M1;H7C2Q9 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 5858000.0 1217200.0 1766000.0 2874800.0 True False 1595760.9873815677 1502519.683814085 2577343.273028816 1.0 0.9415693801861398 1.6151186132566724 20.605813150620193 -6.8857837164207165 1.0470506106522282 0.9600671809142268 1.6684720816607306 0.9780576678819292 0.04513165973981659 0.12262873076683471 0.2423902121956053 0.03301221089824358 0.08114142117441167 1.30081723849199e-07 6.8857837164207165 0.7084049007465038 VEK(ub)TGHSGTLDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEKTGHSGTLDPK 13 1 O60832;O60832-2;C9IYT0;H7C0M1;H7C2Q9 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 4841700.0 1139900.0 1327200.0 2374600.0 True False 1103714.498449713 1857157.8812565666 1752621.0235269864 1.0 1.6826433682488966 1.5879296919527044 20.073935602908666 -10.08149509487053 4.310475499790833 0.9999308730104682 1.6352865301618198 0.9836028952315216 0.03866669670985546 4408583.915544279 2062192.1845294887 2749.2631229717035 0.013236638800415748 8.289052782726644e-11 10.08149509487053 0.6353556571513516 VEK(ub)TGHSGTLDPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEKTGHSGTLDPK 13 1 O60832;O60832-2;C9IYT0;H7C0M1;H7C2Q9 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 9399300.0 2802100.0 2610300.0 3986900.0 True False 4250990.560950034 2144471.5706330147 3198887.467479655 1.0 0.5044639690175545 0.7525040156204794 22.019367624893665 -10.1030134575188 5.403780087550917 1.0000052827431667 0.6284839923188311 0.7494508353658107 0.10126192499287667 6.444767472528475e-06 1.0696036857461837e-06 0.09804783065304883 0.03268214575843147 7.888356735239899e-11 10.1030134575188 -0.37152129042433557 VEK(ub)TGHSGTLDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEKTGHSGTLDPK 13 1 O60832;O60832-2;C9IYT0;H7C0M1;H7C2Q9 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 6731600.0 1217200.0 1779300.0 3735100.0 True False 1667231.733593175 1700684.6426417357 2852946.3067991594 1.0 1.0200649426078665 1.711187622761092 20.669023212143085 -6.913107543991271 0.8743087494265661 0.9806463406398602 1.8067039718407347 0.9920421947682799 0.02949428329778474 0.10239910605450583 0.12788762559168423 0.02452460548699749 0.06924900515817078 1.2214971443607063e-07 6.913107543991271 0.8260576312008745 VEK(ub)TGHSGTLDPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEKTGHSGTLDPK 13 1 O60832;O60832-2;C9IYT0;H7C0M1;H7C2Q9 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 4786000.0 1139900.0 2298100.0 1348000.0 True False 947877.3561322534 2285719.6791628664 1629860.5675522075 1.0 2.4114086747357106 1.7194846537981858 19.854340878342942 -10.301845420224678 7.003905513089191 0.9999862683414776 2.0654466642669482 0.7596987360402239 0.2824767986786267 6.056952889360577e-05 6.037948314132736e-06 0.27351049611397504 0.09116899474769222 4.99062088560537e-11 10.301845420224678 1.0654603959254705 VEK(ub)TGHSGTLDPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEKTGHSGTLDPK 13 1 O60832;O60832-2;C9IYT0;H7C0M1;H7C2Q9 O60832 DKC1 H/ACA ribonucleoprotein complex subunit 4 1 9070600.0 2802100.0 1225100.0 5043400.0 True False 3627373.687648687 1156922.108050549 4125552.9496540157 1.0 0.3189420797724542 1.13733883103956 21.790493946986114 -6.685866992355145 1.8815937095262103 0.5713675000489618 1.134341448362379 0.35097618177799383 0.2882868520761628 0.4255887441810685 2.9181047709442627 0.12273351598985807 0.3212235606532836 2.0612611013632948e-07 6.685866992355145 0.5629739483134173 VEK(ub)VTISNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEKVTISNR 9 1 P08238;Q58FF7 P08238;Q58FF7 HSP90AB1;HSP90AB3P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3 1 5544900.0 1287600.0 2474500.0 1782800.0 True False 1246725.8427966067 3462580.7543470324 1315831.1971464297 1.0 2.777339360015115 1.055429471322106 20.249712818194308 -6.638789936166613 2.0486361138412574 2.1633525172247503 1.0625618557955785 0.1499836771218972 0.7607039216624161 0.5364882328820972 4.301709650464437 0.3025267788987908 0.8424474291093199 2.297259540552651e-07 6.638789936166613 -1.1007906614291718 VEK(ub)YTISQEAYDQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEKYTISQEAYDQR 14 1 Q99426;K7EP07;A0A494C0X0;Q99426-2;K7EK42 Q99426 TBCB Tubulin-folding cofactor B 1 17688500.0 4284500.0 0.0 13404000.0 True False 5546369.710121259 0.0 10964609.536654323 1.0 0.0 1.9768984236023108 22.4031123561273 -6.76917954601336 1.577558584534141 0.4258295468338481 1.987685580720145 0.7274338773500648 0.4213612096219931 0.26775375700101095 1.314948477563912 0.21054697320208496 0.5015746198817858 1.7014549475119698e-07 6.76917954601336 1.561856033886297 VELCSFSGYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VELCSFSGYK 10 0 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 25039600.0 6408200.0 8892700.0 9738700.0 False True 8401212.25709707 7565943.823473104 8731032.744206816 1.0 0.9005776299821068 1.0392586780355568 23.00216608663411 -6.714239246053111 1.7799387910136912 0.9391469131800396 1.0389784769027295 0.48539205294483057 0.04186897505396173 0.36656019336977996 2.2662887834350807 0.01870064297790774 0.047268539396956605 1.9309043189154558e-07 6.714239246053111 0.09983156372268986 VELCSFSGYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VELCSFSGYK 10 0 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 23972100.0 6408200.0 8833600.0 8730300.0 False True 8777484.715093471 8443302.343191173 6668382.946172441 1.0 0.9619273194144503 0.7597145609044139 23.065376148157 -6.938467601459239 0.6736686837388683 1.002341175944509 0.7075576112799719 0.9979562150920598 0.0047671886445395635 0.08847275930418819 0.0578457111771358 0.004588293115894008 0.017524816464898736 1.1522120120932507e-07 6.938467601459239 -0.29478356466453726 VELCSFSGYK(ub)IYPGHGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VELCSFSGYKIYPGHGR 17 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 200670900.0 38133000.0 69062900.0 93475000.0 True False 49992732.28049728 58758984.52507564 83803103.67551449 1.0 1.1753505328613167 1.6763057319074959 25.57521504179916 -6.9525443018704856 0.5301776883702559 0.992109243265493 1.8822952718047679 0.999386113203883 0.007100229709440359 0.08247990836422732 0.03185669271154325 0.007919288507921944 0.041427261307442606 1.1154643583367284e-07 6.9525443018704856 0.8901860285392749 VELCSFSGYK(ub)IYPGHGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VELCSFSGYKIYPGHGR 17 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 264854100.0 77833000.0 121394000.0 65627100.0 True False 75362234.01863012 169867257.2613472 48437393.73920152 1.0 2.2540103736754236 0.6427276787897163 26.167338396675866 -6.698952224441731 1.8341995854890172 1.7794545318586847 0.6475428375727723 0.41284259706585413 0.5294308592666306 0.3976771798451549 2.6002397070536825 0.23031810084448787 0.5931741407048998 2.0000818811151667e-07 6.698952224441731 -1.1319116942859124 VELCSFSGYK(ub)IYPGHGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VELCSFSGYKIYPGHGR 17 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 342804000.0 80850000.0 186789000.0 75165000.0 True False 122655360.92673717 153455043.56088185 60308604.80401009 1.0 1.2511075129650593 0.49169155223498795 26.87003505058427 -6.817576658789188 1.3821947181426988 1.1356857500127937 0.4759400290440612 0.878758112258683 0.10999636488199548 0.19664124320251258 0.7388071921609796 0.06254544299941305 0.14426785845320883 1.5220304504208622e-07 6.817576658789188 -0.6597457209687325 down VELCSFSGYK(ub)IYPGHGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VELCSFSGYKIYPGHGR 17 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 282336700.0 38133000.0 67074700.0 177129000.0 True False 52231800.60557715 64111117.96762862 135294778.28626502 1.0 1.2274345748054307 2.590275975893097 25.638425103322053 -6.935863002366957 0.6969946805614472 0.9830728053572136 2.916985326848197 0.9975701700555579 0.034614839868862525 0.08970574805843255 0.06359189673901024 0.03271941917610655 0.11958998384696805 1.1591429486343514e-07 6.935863002366957 1.9339125214909831 up VELCSFSGYK(ub)IYPGHGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VELCSFSGYKIYPGHGR 17 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 225271300.0 77833000.0 53382300.0 94056000.0 True False 64721588.08653534 53094718.95434313 113722674.73419164 1.0 0.8203556266782789 1.757105752444453 25.947743672110143 -6.8570201929589985 1.2006724798211044 0.9032008417680061 1.7999587530480816 0.949916787071325 0.09084327404975398 0.1499041579124314 0.41234231952156586 0.05907785577439443 0.1374777081721307 1.389888005469385e-07 6.8570201929589985 0.8967579112800755 VELECETIK(ub)QENTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VELECETIKQENTR 14 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 3725340.0 1148600.0 800040.0 1776700.0 True False 1505825.7230582235 680677.1505314942 1592864.1273098297 1.0 0.4520291691850555 1.0578011139794037 20.522123378491628 -6.66845574484948 1.9426160682030507 0.6497740912714289 1.0553490705394717 0.27231583025993433 0.23284832962334817 0.46467715990481134 3.3791694691741077 0.09654243009645244 0.2584794454740561 2.1455777417299818e-07 6.66845574484948 0.40557497926804276 VELECETIK(ub)QENTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VELECETIKQENTR 14 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 27949900.0 1891800.0 4585100.0 21473000.0 True False 2869998.90910577 3766853.0814501876 17228852.138049778 1.0 1.312492861756473 6.003086650446818 21.452618757853013 -6.92041567337843 0.8216276007894289 0.8980483255133536 6.766793068100924 0.9942958208339426 0.17283231845345265 0.0979279151474479 0.10434809421774155 0.14924139739905676 0.44884799266917685 1.2011142697971438e-07 6.92041567337843 5.8687447425875705 up VELECETIK(ub)QENTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VELECETIKQENTR 14 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 5144300.0 1148600.0 1138000.0 2857700.0 True False 1573268.4597478819 1087719.3971372435 2182770.116178936 1.0 0.6913755820869579 1.38741109481641 20.58533344001452 -6.786178908800609 1.5116161827791488 0.8266470907712051 1.3940483896474691 0.7886785905251149 0.13090401469677806 0.24110277403262537 1.0883891443612312 0.06817978088369596 0.16007767807973705 1.6361423692503214e-07 6.786178908800609 0.567401298876264 VELECETIK(ub)QENTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VELECETIKQENTR 14 1 O14777 O14777 NDC80 Kinetochore protein NDC80 homolog 1 31558800.0 1891800.0 6369000.0 23298000.0 True False 2448972.3929530666 6014559.551199037 19058003.05766727 1.0 2.455952369453396 7.78204079086673 21.223745079945463 -6.9469290796526995 0.5915986457793168 0.9387243995661577 9.568006991509021 0.9989377242168419 0.09501235980747275 0.08474281962814886 0.04125010915778502 0.09834121571136341 0.4464087043373772 1.1299804255625201e-07 6.9469290796526995 8.629282591942863 VELFSK(ub)MR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VELFSKMR 8 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 54624500.0 17178900.0 35111000.0 2334600.0 True False 22521704.260704264 29872575.661606062 2093037.987064517 1.0 1.3263905482378415 0.09293426300408524 24.424812667270697 -6.836331900392497 1.2991861991190101 1.173804344879995 0.05519100983281022 0.9179810888771096 0.14944521414175682 0.1731292947875314 0.5692004841606024 0.0902456431762506 0.20776393340908295 1.457699818162244e-07 6.836331900392497 -1.118613335047185 down VELFSK(ub)MR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VELFSKMR 8 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 70610300.0 43376000.0 18610000.0 8624300.0 True False 41999052.62282199 26041070.049867943 6365337.106545862 1.0 0.6200394633596428 0.15155906405105393 25.323853449441703 -7.542819763551523 0.4445937704359075 1.0264526058601748 1.4863401631812216e-24 0.9980654284981108 0.015262470077771036 0.11862996323983074 0.06114778966807071 0.02147443890162276 0.06947533235555237 2.8653668784042224e-08 7.542819763551523 -1.0264526058601748 down VELFSK(ub)MR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VELFSKMR 8 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 30433700.0 17241000.0 6855700.0 6337000.0 True False 26155857.4859354 5632246.771171417 5084489.172394231 1.0 0.2153340518161182 0.19439198944742211 24.64063073189245 VELFSK(ub)MR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VELFSKMR 8 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 51586200.0 17178900.0 31647000.0 2760300.0 True False 23530403.572316635 30248730.89736581 2108373.9901629714 1.0 1.285516876257628 0.08960211768928007 24.488022728793588 -6.843697664452552 1.265035069618271 1.1519003353994086 0.04728100458137932 0.930632839425155 0.13431213416368354 0.16452893889092055 0.5098410392694597 0.08319556001739753 0.19190814673973047 1.4331852687618884e-07 6.843697664452552 -1.1046193308180292 down VELFSK(ub)MR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VELFSKMR 8 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 71228700.0 43376000.0 23691000.0 4161700.0 True False 36069065.882614836 23563371.880704712 5031892.228473306 1.0 0.6532847830711961 0.13950714013080834 25.10425872487598 -7.43717354346065 0.4919780279782524 1.0144366401901916 4.417621069237666e-29 0.9977478516670666 0.016775730588299474 0.11275027929222961 0.06119962534218762 0.01918429199129013 0.06501243295265252 3.654487296365606e-08 7.43717354346065 -1.0144366401901916 down VELFSK(ub)MR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VELFSKMR 8 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2;E7EV93;E9PGW9;Q15154-3;E5RGQ4 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 24993000.0 17241000.0 7752000.0 0.0 True False 22318814.370918613 7320594.385444333 0.0 1.0 0.32800104269799646 0.0 24.4117570539849 -8.605042632730386 0.5027026341840638 1.0612783939106922 8.212524522197824e-21 0.9941496955170858 0.03183569458069023 0.2705746015430748 0.18751558831194215 0.09338857945816167 0.0643603974988044 2.4828893592828104e-09 8.605042632730386 -1.0612783939106922 VELGEK(ub)PLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VELGEKPLR 9 1 Q9BSJ8-2;Q9BSJ8;F8VZB1 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 7796700.0 2282800.0 3210400.0 2303500.0 True False 2992772.9066666486 2731420.834041186 2065155.9167322523 1.0 0.9126722672330804 0.6900476518388505 21.51305137978205 -6.955041787625435 0.5004436297632139 1.0044413848517852 0.5886693101896077 0.9995398389655623 0.0027992698015575444 0.08152218200076734 0.028056126789132687 0.003280089019515497 0.01836479483041678 1.1090680960802639e-07 6.955041787625435 -0.4157720746621776 VELGEK(ub)PLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VELGEKPLR 9 1 Q9BSJ8-2;Q9BSJ8;F8VZB1 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 6150400.0 1328200.0 2344300.0 2477900.0 True False 1286037.0180199235 3280391.215363 1828863.6545934116 1.0 2.550775109423934 1.4220925439683405 20.294500739941146 -10.437444701314451 4.926880917331898 0.9983311204611384 1.9864338266962516 0.5045653332336362 0.4607827278240084 0.008458073679617414 0.0009657491605187025 0.4467436178914045 0.14871698592347773 3.6522062781092967e-11 10.437444701314451 0.9881027062351132 VELGEK(ub)PLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VELGEKPLR 9 1 Q9BSJ8-2;Q9BSJ8;F8VZB1 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 17472000.0 5759400.0 7351800.0 4360800.0 True False 8737430.86853989 6039813.850124423 3498885.9685934633 1.0 0.6912574120467674 0.40044791440829575 23.05877770510447 -7.144124551903562 0.22694589957172162 1.1332198366266366 9.458193351470408e-15 0.9999847644445939 0.0009555144483460216 0.08211732815107557 0.00953234595585956 0.01046261367080883 0.03353073590372535 7.175884635891303e-08 7.144124551903562 -1.133219836626627 down VELGEK(ub)PLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VELGEKPLR 9 1 Q9BSJ8-2;Q9BSJ8;F8VZB1 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 6329200.0 2282800.0 1245300.0 2801100.0 True False 3126812.850350396 1190278.528343591 2139537.870465347 1.0 0.38066829877912467 0.6842551738347842 21.57626144130494 -10.52553961229015 6.386531421628539 1.0004361752164252 0.5324617363070082 0.7597498986862994 0.12393882274873937 0.0007704105394396999 5.7234449219882864e-05 0.12011023927149402 0.04000108303786838 2.9816755748990416e-11 10.52553961229015 -0.46797443890941703 VELGEK(ub)PLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VELGEKPLR 9 1 Q9BSJ8-2;Q9BSJ8;F8VZB1 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 6754300.0 1328200.0 4145800.0 1280300.0 True False 1104457.1492366528 4123465.7525231345 1548004.8105616395 1.0 3.733477351632043 1.401597890539751 20.074906015375422 -6.607380696135285 2.1629493686382086 2.8294008128707917 1.409664190879359 0.042447411833294924 1.1792661438676535 0.6199206823155233 5.491681869021296 0.4507844225683769 1.310126186653323 2.469558417459353e-07 6.607380696135285 -1.4197366219914327 VELHVHLDGSIKPETILYYGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VELHVHLDGSIKPETILYYGR 21 1 P00813;F5GWI4;F5GXW0;F5GYD4 P00813 ADA Adenosine deaminase 0 114083000.0 26717000.0 37600000.0 49766000.0 False True 40531642.274330646 30889986.229859106 39929728.28678733 1.0 0.7621202718800822 0.9851495287689215 25.272545296369838 -10.518242858052979 8.032366548733863 1.0000170599279619 0.8736349003626848 0.299732250360652 0.09105131284829437 2.7820675696307626e-05 1.668652222968611e-06 0.0881719479532227 0.029386684859313793 3.0321951024711795e-11 10.518242858052979 -0.1263821595652771 VELHVHLDGSIKPETILYYGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VELHVHLDGSIKPETILYYGR 21 1 P00813;F5GWI4;F5GXW0;F5GYD4 P00813 ADA Adenosine deaminase 0 82505000.0 26717000.0 28232000.0 27556000.0 False True 34585683.17080398 26660864.38207745 22541090.748436745 1.0 0.7708641824540745 0.6517462915830197 25.043671618462287 -13.9999999999727 0.08290330978469511 2.214967476280933 0.31437928184272024 0.9998744157882123 0.0016195381225793093 12.230030545691996 0.08184487815936851 2.690398837160417 0.3053249941104013 1.0000000000628624e-14 13.9999999999727 -1.9005881944382128 VELQEK(ub)VVQVSAGDSHTAALTDDGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VELQEKVVQVSAGDSHTAALTDDGR 25 1 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 1 8733100.0 2021500.0 3582100.0 3129500.0 True False 2650206.0762338457 3047664.6429164363 2805689.3602837385 1.0 1.1499727022162032 1.0586683750536285 21.337673115264653 -10.418880728523485 6.553936775954645 0.9999837920720065 1.1043205386349024 0.6351146197155643 0.03727483547607435 8.829508706942257e-06 7.829093593775015e-07 0.036096810112467216 0.012030401419288113 3.8117049091072006e-11 10.418880728523485 0.10433674656289593 VELQEK(ub)VVQVSAGDSHTAALTDDGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VELQEKVVQVSAGDSHTAALTDDGR 25 1 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 1 15749000.0 4397400.0 5564300.0 5787300.0 True False 4257806.944015065 7786154.007441164 4271432.514721518 1.0 1.8286770888909554 1.0032001382133133 22.0216791064262 -10.23904537493343 3.66924882950557 0.9993835797307291 1.415938611903337 0.25290748089880355 0.3369995564496714 119845104.67691237 213060825.29494256 928527.8705607093 0.12332923636441663 5.7670620618460974e-11 10.23904537493343 0.4165550321726079 VELQEK(ub)VVQVSAGDSHTAALTDDGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VELQEKVVQVSAGDSHTAALTDDGR 25 1 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 1 18158300.0 5205400.0 6678600.0 6274300.0 True False 7896972.365714751 5486751.649860024 5034181.85487662 1.0 0.6947918006755518 0.637482521368932 22.91286821119865 -13.999999999999998 0.23519398676532127 2.9741629166199854 0.6109604761680596 0.9995173093322358 0.003495764692494938 13.458635316421953 0.15352055004748597 12.44419982308827 0.028816699692497293 1.0000000000000041e-14 13.999999999999998 -2.363202440451926 VELQEK(ub)VVQVSAGDSHTAALTDDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VELQEKVVQVSAGDSHTAALTDDGR 25 1 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 1 8415300.0 2021500.0 4064600.0 2329200.0 True False 2768903.178983405 3885012.5321652293 1779090.9313797753 1.0 1.4030871724419054 0.6425255115034262 21.400883176787545 -6.762728030900361 1.602385302066977 1.233338106673331 0.6393823666671988 0.7019636551957785 0.16961083765138232 0.27834343314706594 1.4091871641656948 0.08349540738114311 0.20010110226473782 1.7269190053741986e-07 6.762728030900361 -0.5939557400061323 VELQEK(ub)VVQVSAGDSHTAALTDDGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VELQEKVVQVSAGDSHTAALTDDGR 25 1 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 1 13549400.0 4397400.0 5732300.0 3419700.0 True False 3656632.937850667 5701418.962127539 4134743.4590936843 1.0 1.559199148241217 1.13075157648283 21.802084381860475 -10.180887454078807 4.516921188758564 0.9999311473653293 1.3449753623678609 0.4636371417333581 0.17491298874361128 0.00012130350071305607 2.1997858719325946e-05 0.16939248711729463 0.0564529243671571 6.593447400279534e-11 10.180887454078807 0.3450442150025316 VELSNGEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 VELSNGEKR 9 1 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 1 35704200.0 16335000.0 16382000.0 2987200.0 True False 21415343.188365035 13937869.456535866 2678113.1992457495 1.0 0.6508356804717618 0.12505581515503192 24.352141461318386 -7.454426414376487 0.5095732045317213 1.0119401406482487 4.462710003041436e-21 0.9972285491373265 0.0189316218693502 0.11348084024281765 0.0672379803417122 0.020752197447694028 0.06652514785306612 3.512154284197177e-08 7.454426414376487 -1.0119401406482487 down VELSNGEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VELSNGEKR 9 1 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 1 38860000.0 17613000.0 18452000.0 2795000.0 True False 17053884.955868762 25819979.825908802 2062905.6517973265 1.0 1.514023337950533 0.1209639713845623 24.023597093673107 -6.806823398900657 1.4279204513007069 1.2812090934910156 0.09834225766997967 0.851346170214861 0.2217662772036931 0.21116849748832306 0.8491887471002351 0.12214171421895897 0.28295732103044147 1.5601868067464138e-07 6.806823398900657 -1.182866835821036 down VELSNGEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 VELSNGEKR 9 1 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 1 6316600.0 3554000.0 1194800.0 1567800.0 True False 5391677.832203138 981578.6049849925 1257923.6428088478 1.0 0.1820543874343289 0.2333083841351918 22.36230286336456 -10.176244475275146 5.923274679174123 1.0000104609136604 0.20768138578477727 0.9968713558566339 0.020924356532609382 2.890599054268719e-06 4.020192164239092e-07 0.020260188004962595 0.0067533070317357885 6.664315125608823e-11 10.176244475275146 -0.7923290751288832 VELSNGEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VELSNGEKR 9 1 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 1 30789900.0 16335000.0 11924000.0 2530900.0 True False 22374490.936776638 11397158.252604978 1933153.5455216686 1.0 0.5093817903973685 0.08639988954314805 24.415351522841277 -7.9715565548567655 0.44645633759584497 1.0419584610099548 1.6032009264651493e-18 0.9961891203629037 0.02304567726039962 0.10150466759009243 0.10136272721676573 0.042307051482313146 0.07972589982321696 1.0676857469173579e-08 7.9715565548567655 -1.0419584610099548 down VELSNGEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VELSNGEKR 9 1 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 1 37168100.0 17613000.0 17785000.0 1770100.0 True False 14645989.888198426 17689188.67495388 2140219.725982315 1.0 1.2077837558257247 0.1461300835464102 23.804002369107383 -6.855914005723306 1.2061833749865474 1.1117309363708265 0.09858770097719229 0.9484722123426473 0.10428095904059763 0.1510801020684451 0.4200128128647369 0.06753200600192312 0.15698642994744208 1.3934326880381645e-07 6.855914005723306 -1.0131432353936343 down VELSNGEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VELSNGEKR 9 1 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 1 5804750.0 3554000.0 1660500.0 590250.0 True False 4600723.059813506 1568091.7153031887 482830.55647644063 1.0 0.3408359283783433 0.10494666820828215 22.13342918545701 -9.888001539509576 0.2705675050061539 1.4995803841513122 5.504723673352407e-25 0.998935317494364 0.01235935638207142 1.3275002310457436 0.12100759420669133 0.6142287031303674 0.09406756486882721 1.2941912537256598e-10 9.888001539509576 -1.4995803841513122 VENACYALK(ub)VR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VENACYALKVR 11 1 Q99598 Q99598 TSNAX Translin-associated protein X 1 2660890.0 840890.0 1820000.0 0.0 True False 1102414.9331903437 1548463.0943044366 0.0 1.0 1.4046100498867953 0.0 20.072235905198298 -6.856758138970509 1.3908128369065123 1.214160942225477 7.61447976407141e-22 0.9043232469684942 0.18260564811606594 0.16835901573718076 0.6546369645702703 0.10576798243078152 0.22157802237260268 1.390726919201562e-07 6.856758138970509 -1.214160942225477 down VENACYALK(ub)VR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VENACYALKVR 11 1 Q99598 Q99598 TSNAX Translin-associated protein X 1 3672990.0 840890.0 1292100.0 1540000.0 True False 1151789.757197802 1235010.7495966882 1176283.7172955764 1.0 1.0722536312541582 1.0212659992370188 20.13544596672119 -10.434192300208698 4.448227524751086 0.999857756836459 1.0467598152456725 0.5286097597167003 0.02081561360608233 2.9452889910236046e-05 3.7463363231175633e-06 0.02021590831125727 0.006718210403080565 3.679660067825515e-11 10.434192300208698 0.046902058409213465 VENETDEGDKAQDGENEK(ub)NSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VENETDEGDKAQDGENEKNSEK 22 2 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 1 3323650.0 1111100.0 1667600.0 544950.0 True False 923928.8800759265 1658616.307807315 658896.5254358872 1.0 1.7951774682819885 0.7131463683457329 19.817422278122862 -6.709736869485711 1.795919110319064 1.4889768512575625 0.7156797664978445 0.46398039782359424 0.3350957608741195 0.3755902020324521 2.3612081648705563 0.14848674798838965 0.3773781191980881 1.9510263303410736e-07 6.709736869485711 -0.773297084759718 VENFEAAVHFYGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VENFEAAVHFYGK 13 0 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 0 48490900.0 5350900.0 33034000.0 10106000.0 False True 8117706.503189581 27138824.604179986 8108544.670382853 1.0 3.343164056684815 0.9988713766871062 22.95264074946235 -6.646260977592342 2.021766707635797 2.5249189207133873 1.0086694386873447 0.17913821937712215 1.0010046047277414 0.5177069192383564 4.051722833571842 0.4021291094739429 1.1086718978905443 2.2580784309117862e-07 6.646260977592342 -1.5162494820260426 VENFEAAVHFYGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VENFEAAVHFYGK 13 0 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 0 24515100.0 5350900.0 12401000.0 6763200.0 False True 6926845.532007905 11710873.448644886 5532366.996292185 1.0 1.6906502959436172 0.7986849094191512 22.7237670715548 -6.700008305133608 1.8312172557434623 1.4288684709501622 0.801369703099133 0.4174846934877551 0.2915317917847368 0.3954839715428227 2.5784181970555946 0.12701823997552533 0.32660831248538436 1.9952241593800924e-07 6.700008305133608 -0.6274987678510292 VENFEAAVHFYGK(ub)AIELNPANAVYFCNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VENFEAAVHFYGKAIELNPANAVYFCNR 28 1 O43765;K7EMD6 O43765 SGTA Small glutamine-rich tetratricopeptide repeat-containing protein alpha 1 32654200.0 8258200.0 12247000.0 12149000.0 True False 10690402.693458606 11565443.684021782 9938006.659266885 1.0 1.0818529493840872 0.9296194862096161 23.3498128627249 -6.760691090171181 1.6101799506302754 1.047504724787162 0.9290503031147896 0.693662146431217 0.034430673625032146 0.2817588118332999 1.4399716044246822 0.016871261425607027 0.04051163910584785 1.7350376759230856e-07 6.760691090171181 -0.11845442167237241 VENLFNEK(ub)CGEALGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VENLFNEKCGEALGLK 16 1 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 1 10359700.0 2935600.0 4807100.0 2617000.0 True False 3848600.028390836 4089899.41792904 2346217.944036601 1.0 1.062697964911437 0.6096289369455714 21.875902313987936 -6.8719153699239675 1.1239842676586704 1.0359015396360018 0.5821191436716306 0.966554183221723 0.03665718720816337 0.1350280110243509 0.3176678496916329 0.025281253363158906 0.06005842991920161 1.3430266484915864e-07 6.8719153699239675 -0.4537823959643712 VENQENVSNLVIEDTELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VENQENVSNLVIEDTELK 18 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 11611900.0 0.0 6041200.0 5570700.0 False True 0.0 5139876.508413165 4994297.401927656 0.0 VENQENVSNLVIEDTELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VENQENVSNLVIEDTELK 18 0 Q01518;Q01518-2 Q01518 CAP1 Adenylyl cyclase-associated protein 1 0 13802900.0 0.0 7335300.0 6467600.0 False True 0.0 7011202.191406688 4940086.084403159 0.0 VEPFLPGHYEVLDLK(ub)PNGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEPFLPGHYEVLDLKPNGK 19 1 P08243-2;P08243;P08243-3;F8WEJ5;C9J057 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 65379600.0 2183000.0 7963600.0 55233000.0 True False 3311770.5986773893 6542433.360109205 44316173.34051613 1.0 1.975509222384556 13.381413965754309 21.659171312326674 -6.923770812362568 0.7962484284463331 0.7808686951883845 15.390384490281416 0.9951661204110123 0.3907958889736475 0.09600359603378107 0.09448363294141346 0.3436192656100532 1.0695528533247756 1.1918708209746918e-07 6.923770812362568 14.609515795093031 up VEPFLPGHYEVLDLK(ub)PNGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEPFLPGHYEVLDLKPNGK 19 1 P08243-2;P08243;P08243-3;F8WEJ5;C9J057 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 1 73894000.0 2183000.0 11826000.0 59885000.0 True False 2825936.533363218 11167872.704110516 48986544.47198925 1.0 3.9519191504344757 17.334623015644706 21.430297634419123 -6.942011384051013 0.6405806419666412 0.8534359976481684 21.167551808405868 0.9984156310092672 0.28290211572402457 0.08686097367025988 0.05052062649504317 0.2797770723856778 1.1420053941961215 1.1428483772027263e-07 6.942011384051013 20.3141158107577 VEPFLPGHYEVLDLKPNGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEPFLPGHYEVLDLKPNGK 19 1 P08243-2;P08243;P08243-3;F8WEJ5;C9J057 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 5655720.0 430620.0 3355000.0 1870100.0 False True 564546.990130012 2854447.0776875694 1676599.9912658953 1.0 5.056172697033078 2.969814772867328 19.10673414331127 -9.399029821826122 8.6972660397531 0.9998455617142187 4.012993734950432 0.7355002487597946 0.8517520605043203 0.0 0.0 0.8247053842485831 0.27490179474952764 3.989975033432655e-10 9.399029821826122 3.013148173236213 VEPFLPGHYEVLDLKPNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEPFLPGHYEVLDLKPNGK 19 1 P08243-2;P08243;P08243-3;F8WEJ5;C9J057 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 5924320.0 430620.0 2952400.0 2541300.0 False True 589831.851067937 2821953.205718799 1941097.279716392 1.0 4.784335061949318 3.2909332993833456 19.169944204834163 -9.671182935124138 10.156212487087075 1.000000000005238 4.03763418090175 0.8465412172970314 0.6096787165432781 0.0 0.0 0.5903188789273071 0.19677295964243563 2.132146613303567e-10 9.671182935124138 3.037634180896512 VEPITK(ub)HIGLVYSGMGPDYR ddPTM_RPMI8226_Bortezomib_1h_R1 2 VEPITKHIGLVYSGMGPDYR 20 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 765723400.0 192765800.0 391158000.0 181799600.0 True False 252717830.54666263 332798751.1219422 162988721.33690342 1.0 1.3168787908714388 0.6449434968016974 27.912952216550337 -6.778468378974983 1.5418627204319308 1.1797819604987674 0.6398765616972537 0.7619226397161226 0.1339196849351312 0.2529626683301395 1.1877371985361038 0.06841725267233097 0.16164225508130955 1.665450084959208e-07 6.778468378974983 -0.5399053988015137 VEPITK(ub)HIGLVYSGMGPDYR ddPTM_RPMI8226_Bortezomib_2h_R1 2 VEPITKHIGLVYSGMGPDYR 20 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 1338003100.0 522190500.0 445784600.0 370028000.0 True False 505613848.41012853 623788715.5159785 273106566.19794667 1.0 1.2337255347681704 0.5401485087022703 28.913460737564485 -6.8158022873192845 1.3898704619154396 1.1265369853070355 0.5263198670243866 0.8744680931019229 0.10208380139137326 0.19899425448337282 0.7564255690359809 0.057732755510596596 0.13324076193690085 1.5282616414207345e-07 6.8158022873192845 -0.6002171182826489 VEPITK(ub)HIGLVYSGMGPDYR ddPTM_RPMI8226_Bortezomib_8h_R1 2 VEPITKHIGLVYSGMGPDYR 20 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 2186125600.0 770187000.0 507121300.0 908817300.0 True False 1168429987.2118845 416621541.8581979 729189162.3062278 1.0 0.3565652597228723 0.6240760424561029 30.121924143837983 -10.374073782738543 5.910733783757073 1.00010176859969 0.4903206510895541 0.8287687127031205 0.10921081973149323 0.00014649037577295175 1.5512676399728586e-05 0.10576383133900402 0.03524764050381086 4.2259681275712134e-11 10.374073782738543 -0.5097811175101359 VEPITK(ub)HIGLVYSGMGPDYR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VEPITKHIGLVYSGMGPDYR 20 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 818190300.0 192765800.0 261516500.0 363908000.0 True False 264036525.55987117 249961836.3105812 277960425.3205183 1.0 0.9466941582440325 1.0527347484637684 27.97616227807323 -6.770047211637895 1.5744380958964201 0.9694270345496782 1.0533299821494908 0.7306923816051899 0.02246585335570591 0.26634780527314555 1.3030338977942952 0.011247655057403052 0.02677113031959753 1.6980590484432506e-07 6.770047211637895 0.08390294759981265 VEPITK(ub)HIGLVYSGMGPDYR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VEPITKHIGLVYSGMGPDYR 20 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 1387800300.0 522190500.0 521114800.0 344495000.0 True False 434224537.7115361 518307451.1392115 416527311.73508763 1.0 1.1936392491101764 0.9592440674363615 28.69386601299876 -6.687335882468612 1.8761613207890417 1.1217058585824506 0.9600862241518316 0.3578048035292447 0.0819413611602995 0.42245159287604506 2.881016399590161 0.0349689435224089 0.09135916118141398 2.0543011890817413e-07 6.687335882468612 -0.161619634430619 VEPITK(ub)HIGLVYSGMGPDYR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VEPITKHIGLVYSGMGPDYR 20 1 A0A024RA52;P25787 A0A024RA52 PSMA2 Proteasome subunit alpha type;Proteasome subunit alpha type-2 1 1735398500.0 770187000.0 612687500.0 352524000.0 True False 997022254.1554823 578590902.0294024 288368249.2016953 1.0 0.5803189443544488 0.28922950114684726 29.893050465930433 -8.154124889955913 0.22938430992954756 1.2217597643376494 1.1947796767715932e-19 0.9996606617097618 0.00537435448595576 0.08801092617806207 0.046867436411505724 0.08991322351507393 0.10555281897297049 7.01253610095763e-09 8.154124889955913 -1.2217597643376494 down VEPWK(ub)EQFFESYYGQSSGLSLEDSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEPWKEQFFESYYGQSSGLSLEDSK 25 1 A0A5F9ZHN2;E7EWD6;Q76L83-2;Q76L83 A0A5F9ZHN2 ASXL2 Putative Polycomb group protein ASXL2 1 137064000.0 44108000.0 50261000.0 42695000.0 True False 66915060.726735 41291531.85901467 34256314.536116704 1.0 0.6170738158280891 0.5119372853296995 25.995827622318927 -13.999999999999899 0.1813731595130156 2.995278349614935 0.42959522846272885 0.9994965460841682 0.004705939020929116 12.222838621701401 0.13501860332745425 8.597297114141995 0.07759230672698973 1.0000000000002332e-14 13.999999999999899 -2.5656831211522064 VEPWK(ub)EQFFESYYGQSSGLSLEDSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEPWKEQFFESYYGQSSGLSLEDSK 25 1 A0A5F9ZHN2;E7EWD6;Q76L83-2;Q76L83 A0A5F9ZHN2 ASXL2 Putative Polycomb group protein ASXL2 1 18138700.0 11066000.0 4935900.0 2136800.0 True False 9201869.306921244 4909309.32700056 2583595.000553086 1.0 0.533512177064718 0.28076849544144455 23.133495535481092 -9.233986276390748 0.18868176562908662 1.463637174878722 1.9646225947662432e-11 0.9996136293516787 0.005855922690529523 0.6659521252356758 0.06780866934599589 0.3293799679618895 0.14897059332401935 5.83463541300866e-10 9.233986276390748 -1.4636371748590757 VEPWK(ub)EQFFESYYGQSSGLSLEDSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEPWKEQFFESYYGQSSGLSLEDSK 25 1 A0A5F9ZHN2;E7EWD6;Q76L83-2;Q76L83 A0A5F9ZHN2 ASXL2 Putative Polycomb group protein ASXL2 1 104551000.0 44108000.0 26545000.0 33898000.0 True False 57098675.498664685 25067747.41506968 27728911.82285197 1.0 0.4390250245937126 0.4856314368185378 25.766953944411377 -10.026012590800043 7.567958055052854 1.000000022878232 0.4623282322276308 0.9943962640486481 0.01902698811543913 7.310697962494685e-09 9.794017358598548e-10 0.0184228025739349 0.006140934008298524 9.418622902314609e-11 10.026012590800043 -0.5376717906506012 VEPWK(ub)EQFFESYYGQSSGLSLEDSKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEPWKEQFFESYYGQSSGLSLEDSKK 26 2 A0A5F9ZHN2;E7EWD6;Q76L83-2;Q76L83 A0A5F9ZHN2 ASXL2 Putative Polycomb group protein ASXL2 1 47984500.0 20530000.0 8240500.0 19214000.0 True False 19878286.387553863 11530974.623639787 14181276.992355544 1.0 0.5800789061404975 0.7134054070794897 24.244690058599957 -10.849242411386857 10.757575636511197 1.0084392849506283 0.6467421566099943 0.9034776236352291 0.0544303160818722 0.010808129485466418 0.0001514657761266537 0.05170278843868012 0.017567308976158078 1.4150037428230778e-11 10.849242411386857 -0.36169712834063394 VEPWK(ub)EQFFESYYGQSSGLSLEDSKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEPWKEQFFESYYGQSSGLSLEDSKK 26 2 A0A5F9ZHN2;E7EWD6;Q76L83-2;Q76L83 A0A5F9ZHN2 ASXL2 Putative Polycomb group protein ASXL2 1 43795000.0 20530000.0 16047000.0 7218000.0 True False 17071604.633209225 15960551.625919897 8727250.427738743 1.0 0.9349180682682865 0.5112144180495902 24.025095334034233 -6.934133951822286 0.7120502181642191 1.0055616364281104 0.41430710632270945 0.9972899971326986 0.01128145702399831 0.09054777396572683 0.06757855312907893 0.010543452098071617 0.037504818209155306 1.1637670270198126e-07 6.934133951822286 -0.5912545301054009 VEQATKPSFESGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEQATKPSFESGR 13 1 P38159;P38159-2;H3BT71;H0Y6E7 P38159 RBMX RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed 0 12728250.0 268750.0 6969800.0 5489700.0 False True 352333.8525787018 5929933.008067612 4921678.504920796 1.0 16.830437849405985 13.96879257811716 18.42658357146978 -9.91318285513692 8.26535384072999 0.9999999850231303 15.399615213761573 0.9712317170664186 1.1682617899176613 3.128604239142313e-07 4.894357822146781e-08 1.1311646140903038 0.37705487136346394 1.2212853425132688e-10 9.91318285513692 14.399615228738442 VEQATKPSFESGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEQATKPSFESGR 13 1 P38159;P38159-2;H3BT71;H0Y6E7 P38159 RBMX RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed 0 11286000.0 3248400.0 1448400.0 6589200.0 False True 3145281.3200842626 2026753.673306217 4863290.848237183 1.0 0.6443791403854202 1.5462180814105666 21.58475762965275 -6.799726626751243 1.4569714491695078 0.803716094575803 1.5585911486736035 0.8313683951352531 0.15231126763635722 0.2211537592420599 0.9268448332737472 0.08224071678674037 0.19129839235667506 1.585891141573988e-07 6.799726626751243 0.7548750540978005 VEQATKPSFESGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEQATKPSFESGR 13 1 P38159;P38159-2;H3BT71;H0Y6E7 P38159 RBMX RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed 0 12944850.0 268750.0 6322500.0 6353600.0 False True 368114.1376956665 6043151.044288413 4853010.536499461 1.0 16.416514405335086 13.183439698563339 18.489793632992672 -9.860810925053181 7.169703417235774 0.9999999117686512 14.799977051949282 0.9604618684148429 1.3198972219817777 1.977576046300889e-06 3.1873218546486887e-07 1.277984989856961 0.4259949966200334 1.377809182934254e-10 9.860810925053181 13.799977140180632 VEQHVVDGK(ub)ER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEQHVVDGKER 11 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 24380800.0 8979400.0 11112000.0 4289400.0 True False 11772080.356633289 9454132.914236745 3845574.034830189 1.0 0.8030978916066916 0.32666902691190847 23.48886595952303 -6.956158626604013 0.48656658130550506 1.0107581253806077 0.09892350899209934 0.9996001099668664 0.005652653465325807 0.08110306675941178 0.0264276059664664 0.006809513047256135 0.03929520960187883 1.1062196620606462e-07 6.956158626604013 -0.9118346163885084 down VEQHVVDGK(ub)ER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEQHVVDGKER 11 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 29747700.0 13809000.0 10141000.0 5797700.0 True False 13370640.853664437 14190354.184616363 4279108.442728207 1.0 1.061306959024875 0.32003764737689816 23.672565279549033 -6.886837015354539 1.0409496918430803 1.0429017317772977 0.2601052303344555 0.9787939403944297 0.04891785579723343 0.12174541250299525 0.23715838623221352 0.035947897718494104 0.08865358125866173 1.297666175581866e-07 6.886837015354539 -0.7827965014428422 down VEQHVVDGK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEQHVVDGKER 11 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 53672300.0 13349000.0 7177200.0 33146100.0 True False 20251408.94262232 5896372.584280452 26594758.80654825 1.0 0.2911586349861612 1.3132300513953545 24.271518947706245 -6.720140932004258 1.7588236943447748 0.5688355193261941 1.3116556213184751 0.5133056477965579 0.29827450495684776 0.35497738764306846 2.146144257539787 0.13465256542659496 0.3379702985533507 1.9048424811627017e-07 6.720140932004258 0.742820101992281 VEQHVVDGK(ub)ER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEQHVVDGKER 11 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 24811000.0 8979400.0 9847500.0 5984100.0 True False 12299326.839160815 9412404.88867222 4570778.826408083 1.0 0.76527805234863 0.37162837333949145 23.55207602104592 -6.963336523651275 0.38553730305823297 1.0254116691277364 0.09745108478751444 0.9998746417160423 0.002902673066636234 0.07853006867908548 0.01687903066191103 0.005097560211938181 0.033177688698299894 1.0880866361717945e-07 6.963336523651275 -0.927960584340222 down VEQHVVDGK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEQHVVDGKER 11 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 28573600.0 13809000.0 11282000.0 3482600.0 True False 11482795.34242503 11221221.626698337 4210795.558276938 1.0 0.9772203798877904 0.36670474677184905 23.45297055498331 -6.914790389898407 0.8624774961052923 1.0161612494080832 0.2791547092207084 0.9926071356483065 0.02521987054138276 0.10133498717846233 0.12221582418876882 0.021149923910087243 0.060515550092569224 1.2167731285303145e-07 6.914790389898407 -0.7370065401873748 down VEQHVVDGK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEQHVVDGKER 11 1 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 1 36831300.0 13349000.0 5121300.0 18361000.0 True False 17280543.648129012 4836295.153015496 15019486.39976946 1.0 0.27986938672147205 0.8691558961106898 24.042645269798694 -10.353876450934207 8.122925596832909 1.0000024014477753 0.5745126414164716 0.41007086094550804 0.2405752100515653 1.0462570323897928e-05 8.324113460649657e-07 0.23293725708583674 0.07764531517000528 4.427142988040008e-11 10.353876450934207 -0.4254897600313037 VEQLGAEGNVEESQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEQLGAEGNVEESQK 15 0 Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 Q9Y383 LUC7L2 Putative RNA-binding protein Luc7-like 2 0 14900200.0 1594400.0 7224200.0 6081600.0 False True 2090273.8401915636 6146377.51971105 5452334.370826515 1.0 2.9404652163411105 2.6084306591747017 20.995260526944655 -10.087082905358452 6.206972357907427 0.9999961751704544 2.7744479377579285 0.974411563975473 0.13555254033819267 7.174611199224237e-06 1.0552384888743112e-06 0.13124846600021142 0.043749394272148905 8.183085608668348e-11 10.087082905358452 1.774451762587474 VEQLGAEGNVEESQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEQLGAEGNVEESQK 15 0 Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 Q9Y383 LUC7L2 Putative RNA-binding protein Luc7-like 2 0 15670800.0 3449900.0 1055900.0 11165000.0 False True 3340384.8128797887 1477526.3764457568 8240551.557179645 1.0 0.44232220513898285 2.466946779726064 21.671582880303266 -6.83326441387946 1.3133118839617066 0.7026282564122396 2.5251314424526954 0.9122395708384752 0.2529575339439703 0.17681612160686547 0.595286271195868 0.15117849948258777 0.34790292407422746 1.46803221543799e-07 6.83326441387946 1.8225031860404557 up VEQLGAEGNVEESQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEQLGAEGNVEESQK 15 0 Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 Q9Y383 LUC7L2 Putative RNA-binding protein Luc7-like 2 0 12807600.0 1594400.0 4580200.0 6633000.0 False True 2183892.7670398927 4377831.6193040395 5066422.010923078 1.0 2.0046000817328915 2.3199042038086164 21.058470588467546 -10.349924879668759 0.25734182444544534 7.242163853893135e-11 2.475553422091956 0.9991133085880187 0.016758965707694903 1.9128515369291605 0.12404196254491572 1.4136705331199773 0.13737345171430518 4.467608621209717e-11 10.349924879668759 2.4755534220195345 VEQLGAEGNVEESQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEQLGAEGNVEESQK 15 0 Q9Y383;Q96HJ9-2;A0A0A6YYJ8;Q9Y383-3;Q9Y383-2 Q9Y383 LUC7L2 Putative RNA-binding protein Luc7-like 2 0 5769040.0 3449900.0 1433600.0 885540.0 False True 2868744.7064836095 1425876.91225268 1070702.3197256548 1.0 0.4970386207702887 0.37323025548623256 21.451988155737542 -13.999999999999998 0.19687558435277536 3.7633236294045473 0.29030207538970315 0.9994870719567194 0.006138371299412497 12.470859621038139 0.14070289229050234 13.253216531496053 0.08071163756526091 1.0000000000000041e-14 13.999999999999998 -3.4730215540148444 VESEIKVPDVELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VESEIKVPDVELK 13 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 12157300.0 5129500.0 1459400.0 5568400.0 False True 4966666.830246342 2042146.0306704587 4109868.9915807634 1.0 0.4111703282036275 0.827490373735602 22.243846541693706 -10.246291007057746 5.759901048193871 1.0000173483842674 0.6193303509696401 0.52713265365092 0.1699619468742841 3.786585581927915e-05 4.9551902680067545e-06 0.16457243765681975 0.05485498247775507 5.67164439021658e-11 10.246291007057746 -0.3806869974146273 VESK(ub)GNSPPSSGEACR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VESKGNSPPSSGEACR 16 1 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 9466200.0 2328200.0 4314300.0 2823700.0 True False 3052292.7463208684 3670623.257009684 2531530.6108430047 1.0 1.202579032248506 0.8293865697824782 21.54146190745047 -6.759301161332311 1.615229050843928 1.1177720589645164 0.8280760386381071 0.6880616808815001 0.0851965483919295 0.28409167013001513 1.460667910101643 0.041621136627546046 0.10008617596046485 1.7405994368183843e-07 6.759301161332311 -0.2896960203264093 VESK(ub)GNSPPSSGEACR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VESKGNSPPSSGEACR 16 1 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 8786700.0 3964300.0 3128300.0 1694100.0 True False 3838455.4664481105 4377446.50386899 1250364.3880893902 1.0 1.1404187288695136 0.325746748664615 21.87209447945026 -6.862469012057477 1.1731069766012534 1.0767515288856895 0.2843777736571588 0.9565768203336515 0.07409954029916589 0.14428513880583171 0.3758998113371293 0.049211752717469415 0.11522038007882471 1.3725588928498544e-07 6.862469012057477 -0.7923737552285306 down VESK(ub)GNSPPSSGEACR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VESKGNSPPSSGEACR 16 1 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 8183800.0 2328200.0 3423600.0 2432000.0 True False 3188998.4572392576 3272334.031668774 1857611.6886122343 1.0 1.0261322090765954 0.58250629892759 21.60467196897336 -6.892913084328153 1.0049670470674943 1.0221986456446759 0.5420958949929486 0.9826990739178831 0.026733818546192233 0.1168123012639619 0.2082847336504694 0.020187216125798612 0.050885798982531476 1.2796373732951082e-07 6.892913084328153 -0.48010275065172725 VESK(ub)GNSPPSSGEACR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VESKGNSPPSSGEACR 16 1 P41227;P41227-2 P41227 NAA10 N-alpha-acetyltransferase 10 1 18925100.0 6324500.0 4635900.0 7964700.0 True False 8187189.924533064 4377908.089716385 6515206.324723258 1.0 0.5347265826334264 0.7957805284570624 22.964936932350536 -10.147545651214902 5.417063676881122 1.0000080707981134 0.6652535555451544 0.6867512723435396 0.10657482710166315 1.0388354810920464e-05 1.6347993815272795e-06 0.10319311952810539 0.03439687754076038 7.119579580304905e-11 10.147545651214902 -0.33475451525295896 VESLWPIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VESLWPIFR 9 0 P41223-2;P41223 P41223-2 BUD31 Protein BUD31 homolog 0 1758930.0 423950.0 521350.0 813630.0 False True 555802.5555376395 443566.61220638367 729443.3724900644 1.0 0.7980650822616537 1.3124145710061703 19.08421294239199 -6.800228155635543 1.455173373084873 0.8886165589383691 1.3195394189845102 0.8327792927130446 0.08652503679903949 0.22043123982774304 0.9215251825359883 0.04677866095777662 0.10876547771780724 1.5840607910334987e-07 6.800228155635543 0.4309228600461411 VESLWPIFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VESLWPIFR 9 0 P41223-2;P41223 P41223-2 BUD31 Protein BUD31 homolog 0 2073050.0 423950.0 598100.0 1051000.0 False True 580695.7718179639 571673.9643477892 802775.446024448 1.0 0.9844637968657315 1.382437215809626 19.14742300391488 -6.897816375349164 0.9749864882391924 0.9824477565666875 1.4224047001625506 0.9854476910492704 0.02220296066950234 0.11303002732884992 0.1866312075919232 0.0171475367155928 0.04414489945908102 1.2652712054603237e-07 6.897816375349164 0.4399569435958631 VESPAK(ub)IHVFYIDYGNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VESPAKIHVFYIDYGNR 17 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 12821400.0 2319300.0 2213700.0 8288400.0 True False 2245675.0910206335 3097641.954292995 6117419.39332985 1.0 1.3793811788174364 2.724089258410732 21.09871778001856 -6.947654243454801 0.5840283996175202 0.9841569812432209 3.1862868242097897 0.9990041138942671 0.023343792572315315 0.08444157243622755 0.03996758611974276 0.024352896386244428 0.11245713186573475 1.1280952135650321e-07 6.947654243454801 2.2021298429665688 up VETFSGVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VETFSGVYK 9 0 P62081;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 0 44100300.0 3137300.0 21706000.0 19257000.0 False True 4113030.6816564146 18467549.40932531 17264470.366187535 1.0 4.490010126033874 4.197505854547802 21.971770403163067 -10.067490518736033 4.387883334270277 0.9997353056564678 4.343757990636279 0.9942934895130666 0.11941436999481252 3896454.4629504303 2235011.1094012572 9357.85229896131 0.040878714937227834 8.560704007460525e-11 10.067490518736033 3.344022684979811 VETFSGVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VETFSGVYK 9 0 P62081;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 0 25096400.0 9617200.0 2880200.0 12599000.0 False True 9311907.25018912 4030278.880044576 9298943.938101789 1.0 0.43280917343358666 0.9986078778773202 23.150645257901278 -10.89223797221534 11.18524702535173 1.0177181728870086 0.7157085256554534 0.2518453298178267 0.23098635383582272 0.08974973866051493 0.0008646742790827654 0.19667637024260043 0.07455052513394296 1.2816281204526327e-11 10.89223797221534 -0.3020096472315552 VETFSGVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VETFSGVYK 9 0 P62081;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 0 34923300.0 3137300.0 15391000.0 16395000.0 False True 4297244.592344613 14710974.728769144 12522838.665623995 1.0 3.4233505709626626 2.9141554306526984 22.034980464685958 -10.103701403974867 5.09902254096393 0.9999416604601772 3.1687530008124547 0.9602977175554814 0.20787804556065795 0.00013787001563199256 2.4235267807808018e-05 0.20128237158493992 0.06709235070583115 7.87587103393511e-11 10.103701403974867 2.1688113403522777 VETFSGVYK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 VETFSGVYKK 10 1 P62081;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 5761030.0 2290000.0 783130.0 2687900.0 True False 2217305.2034826237 1095837.8929689978 1983858.3547284538 1.0 0.49422059319926437 0.8947159604426557 21.080375934588297 -9.900869690500516 6.654056218522031 1.0000000148382067 0.6944682768209537 0.43693390072264116 0.16350154901583952 3.6096654646839553e-08 5.849586238708565e-09 0.15830970236083897 0.05276989803478435 1.256406890411804e-10 9.900869690500516 -0.305531738017253 VETFSGVYK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VETFSGVYKK 10 1 P62081;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 6850900.0 2290000.0 3068900.0 1492000.0 True False 1904236.464201123 3052367.226571048 1803970.3017714354 1.0 1.6029349736518128 0.947345739715287 20.860781210022573 -6.664901604892546 1.9553526135556778 1.3865239427814362 0.9500420437575561 0.25668561504016685 0.25641823533837804 0.47294414040701593 3.481007812253791 0.10575683378516963 0.28445738761839434 2.163208571467994e-07 6.664901604892546 -0.4364818990238801 VETFSGVYK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VETFSGVYKK 10 1 P62081;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 18245350.0 846050.0 2030400.0 15368900.0 True False 1095228.4031387775 1917406.4551349548 12571917.89823085 1.0 1.7506909514398326 11.478809225729924 20.062800335693066 -6.922314131499643 0.8073713657329324 0.8027281870624393 13.134247530983908 0.9948000852995335 0.34415918314391075 0.09682933447071425 0.09869640551078789 0.3002214321027689 0.9202120979694851 1.1958752245004662e-07 6.922314131499643 12.33151934392147 up VETGVLK(ub)PGMVVTFAPVNVTTEVK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VETGVLKPGMVVTFAPVNVTTEVK 24 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 48933100.0 18919900.0 20518000.0 9495200.0 True False 24804172.120572224 17456794.37853758 8512727.788389878 1.0 0.7037846009808635 0.3431974164269544 24.564079469961506 -7.045675976767479 0.303273754034754 1.0631557889533145 2.7208297348736653e-12 0.9999629109024084 0.0016355876244685107 0.07277531966199165 0.01153349229955273 0.006213167966398582 0.031019358871340903 9.001689390543751e-08 7.045675976767479 -1.0631557889505936 down VETGVLK(ub)PGMVVTFAPVNVTTEVK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VETGVLKPGMVVTFAPVNVTTEVK 24 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 275298400.0 96568000.0 79240900.0 99489500.0 True False 93502501.69865066 110882204.60583451 73430215.3289767 1.0 1.185874202202599 0.7853288842007142 26.478501629639126 -6.780513336824851 1.533735801239422 1.1051779521760157 0.7820978736500778 0.769225308412625 0.07862197160353528 0.2497896594149429 1.1606184979159664 0.04037218285794319 0.09522596346038051 1.6576264317285907e-07 6.780513336824851 -0.3230800785259379 VETGVLK(ub)PGMVVTFAPVNVTTEVK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VETGVLKPGMVVTFAPVNVTTEVK 24 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 1025091300.0 231453000.0 153648000.0 639990300.0 True False 351131122.4808421 126228313.94269668 513495936.6872863 1.0 0.35949053177302376 1.4624050783630065 28.38743463415222 -6.749252953981808 1.6525054087391053 0.6230382773485356 1.464486756843002 0.6457930583386859 0.2691374712406951 0.3013498347364963 1.6188432807385065 0.12866746865564863 0.3126279842587226 1.781340926652561e-07 6.749252953981808 0.8414484794944664 VETGVLK(ub)PGMVVTFAPVNVTTEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VETGVLKPGMVVTFAPVNVTTEVK 24 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 57422500.0 18919900.0 13150600.0 25352000.0 True False 25915098.32107254 12569563.008781211 19364379.740829505 1.0 0.4850285672487851 0.7472238577263509 24.627289531484397 -10.131089252303092 5.539758853892566 1.0000058970176848 0.6161262124875004 0.7407999561999223 0.10704077910538733 7.796172330569031e-06 1.2227737887519314e-06 0.10364338038438539 0.03454726290331708 7.394532936392933e-11 10.131089252303092 -0.3838796845301844 VETGVLK(ub)PGMVVTFAPVNVTTEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VETGVLKPGMVVTFAPVNVTTEVK 24 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 268741600.0 96568000.0 111438200.0 60735400.0 True False 80300570.68776159 110837860.29784906 73434891.3312392 1.0 1.3802873298226956 0.9145002420565763 26.258906905073403 -6.689689785869494 1.8678827014057686 1.2384928597422682 0.9161329552791677 0.3687947719195295 0.16084600777344893 0.41734374688483 2.822987725468807 0.06889990488766648 0.1794662151970042 2.0431968677043792e-07 6.689689785869494 -0.3223599044631005 VETGVLK(ub)PGMVVTFAPVNVTTEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VETGVLKPGMVVTFAPVNVTTEVK 24 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 1 953300000.0 231453000.0 187435000.0 534412000.0 True False 299620471.1207134 177004077.4813932 437154499.5301778 1.0 0.590760961089606 1.4590274753091006 28.15856095624467 -6.778527328089336 1.5414448261358082 0.7678320504312776 1.4656085274768529 0.7621747494242656 0.1729594445290864 0.25288302478194363 1.1866939313228095 0.08838172159681922 0.20881617566718932 1.6652240398472688e-07 6.778527328089336 0.6977764770455753 VETGVLKPGMVVTFAPVNVTTEVK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VETGVLKPGMVVTFAPVNVTTEVK 24 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 1272957250.0 580803150.0 482248400.0 209905700.0 False True 761438554.1557051 410298818.5095399 188186671.7216519 1.0 0.5388469184680117 0.2471462348400735 29.50415237927627 -8.439533904583733 0.23947678262145047 1.242900761164346 2.8516072739640272e-12 0.9994679707137445 0.007148896027643117 0.13777767272038982 0.06025621365320721 0.12766719176452812 0.111939175070207 3.634679281555063e-09 8.439533904583733 -1.2429007611614944 down VETGVLKPGMVVTFAPVNVTTEVK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VETGVLKPGMVVTFAPVNVTTEVK 24 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 3977573800.0 1409263700.0 970943700.0 1597366400.0 False True 1364527395.2354498 1358646582.814506 1178968219.875185 1.0 0.9956902203345438 0.8640121290285664 30.345754213474518 -6.9138631545323115 0.8690093734161365 1.0035959464487612 0.8455098528588523 0.9922996737529441 0.005538345518674834 0.10191859696605839 0.1253188602431055 0.004622773052037947 0.013129875923122333 1.2193737610378245e-07 6.9138631545323115 -0.15808609358990888 VETGVLKPGMVVTFAPVNVTTEVK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VETGVLKPGMVVTFAPVNVTTEVK 24 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 6268425000.0 916897000.0 1796434000.0 3555094000.0 False True 1390999783.1495652 1475846317.0970948 2852428112.6469455 1.0 1.0609967988315685 2.0506316012417685 30.373475048956944 -6.919496365722903 0.8284565507208701 0.9777656543094456 2.2083834452952 0.9940398413323069 0.03717585885067373 0.0984688933767266 0.10715737314474309 0.03194570938012372 0.09523626215992667 1.20365946225102e-07 6.919496365722903 1.2306177909857543 up VETGVLKPGMVVTFAPVNVTTEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VETGVLKPGMVVTFAPVNVTTEVK 24 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 1769039950.0 580803150.0 302915700.0 885321100.0 False True 795541770.1699607 289531882.76573455 676226489.9403937 1.0 0.3639430305512161 0.8500200935972522 29.56736244079916 -9.955858354462949 6.721057604223232 1.0000000377291307 0.6069815620743082 0.46571905974781 0.19844013002225105 1.121556721837733e-07 1.7465522526862026e-08 0.19213884974042408 0.06404627656628271 1.1069847691877254e-10 9.955858354462949 -0.3930184756548225 VETGVLKPGMVVTFAPVNVTTEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VETGVLKPGMVVTFAPVNVTTEVK 24 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 3504741500.0 1409263700.0 1068175400.0 1027302400.0 False True 1171865207.5174656 1062420927.103985 1242106582.1303747 1.0 0.9066067669631284 1.0599398072084687 30.126159488908794 -6.741821463877482 1.6800444015845448 0.9445525249303787 1.0600669244472174 0.6132231383937401 0.039238169408183886 0.31446072924341845 1.7434555779628191 0.018471621408102067 0.0452370809049896 1.8120848778544016e-07 6.741821463877482 0.11551439951683873 VETGVLKPGMVVTFAPVNVTTEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VETGVLKPGMVVTFAPVNVTTEVK 24 1 P68104;Q5VTE0;A0A087WVQ9 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3 0 6738546900.0 916897000.0 3232366300.0 2589283600.0 False True 1186941241.24193 3052482273.9266663 2118060553.093303 1.0 2.5717214701654214 1.7844695925108447 30.144601371049394 -10.126170581528038 5.544739038239086 0.9999831725713106 2.1780955313383545 0.7491143710158367 0.321394233217729 6.685777595893217e-05 1.0536022769748317e-05 0.31119305586566676 0.10372954273483377 7.47875693333613e-11 10.126170581528038 1.178112358767044 VEVCGTSWTYNPAAVSK(ub)VASAGSAISNASGER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEVCGTSWTYNPAAVSKVASAGSAISNASGER 32 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 13226300.0 6361000.0 3486600.0 3378700.0 True False 6159073.536835365 4878817.562378808 2493717.1111726733 1.0 0.7921349750413316 0.4048851010234872 22.554281922787244 -6.961409089920537 0.4151041426667537 1.0180466127571282 0.16448221315403616 0.9998189277093719 0.003318406124809691 0.07920164320571686 0.019299993780467258 0.004995937300404096 0.032281068967014784 1.0929263835512923e-07 6.961409089920537 -0.8535643996030919 down VEVCGTSWTYNPAAVSK(ub)VASAGSAISNASGER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEVCGTSWTYNPAAVSKVASAGSAISNASGER 32 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 15966600.0 6361000.0 2867600.0 6738000.0 True False 5289453.340080069 2852151.6696259654 8146884.647007982 1.0 0.5392148273648995 1.5402129715893587 22.33468719822152 -6.781510921687011 1.5297350797703977 0.7396092232494009 1.5485592859149993 0.7727994699630756 0.19499235016081365 0.24822303497953616 1.147368144198771 0.10038192143178633 0.23658650671934942 1.6538231937146435e-07 6.781510921687011 0.8089500626655983 VEVCGTSWTYNPAAVSK(ub)VASAGSAISNASGER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEVCGTSWTYNPAAVSKVASAGSAISNASGER 32 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 27733400.0 7016900.0 14949000.0 5767500.0 True False 9083515.373777542 14117075.00877287 4717874.179547435 1.0 1.5541422486635845 0.519388583099345 23.11481930635768 -6.761234058347042 1.6078787423218537 1.3213793269469207 0.5153795694709604 0.6959886100480449 0.23311567524229201 0.2808362094031581 1.4312329116751112 0.11437954409157226 0.2745322415308088 1.7328698344604832e-07 6.761234058347042 -0.8059997574759603 VEVEEDGQLK(ub)SLTINGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEVEEDGQLKSLTINGK 17 1 O75190-2 O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 36067700.0 8437700.0 12051000.0 15579000.0 True False 11061906.410803031 10253037.774430072 13967034.524320297 1.0 0.9268780076115072 1.2626245427894893 23.399096705516367 -6.849652107901314 1.2366857699394147 0.9609889758892547 1.2759625398205103 0.9398069803654765 0.03536909456218535 0.15784184776361268 0.4647011527961296 0.02238074550842365 0.05178159770838631 1.4136695127836624e-07 6.849652107901314 0.31497356393125564 VEVEEDGQLK(ub)SLTINGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEVEEDGQLKSLTINGK 17 1 O75190-2 O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 75496000.0 25722000.0 18413000.0 31361000.0 True False 24905469.189510945 25765406.922526475 23146613.29016666 1.0 1.0345280679706166 0.9293787285852445 24.56995925414212 -6.81822583889198 1.3793977365958614 1.0186446949507437 0.927166876364422 0.8802848103188483 0.015141565187800982 0.19579584315668128 0.7324911209296106 0.008626737644382518 0.01989456902729152 1.5197570303981965e-07 6.81822583889198 -0.09147781858632176 VEVEEDGQLK(ub)SLTINGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEVEEDGQLKSLTINGK 17 1 O75190-2 O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 156142000.0 33012000.0 52987000.0 70143000.0 True False 50081617.500475496 43531055.86067937 56279205.30523099 1.0 0.8692022748719342 1.1237497531843226 25.57777782237325 -6.767006667082455 1.5856978246152167 0.924693766256591 1.1250300822775694 0.7190912831156013 0.05508473496457703 0.271280255495161 1.3456743819964943 0.02738829216417386 0.06538184820021671 1.7099890639494805e-07 6.767006667082455 0.20033631602097834 VEVEEDGQLK(ub)SLTINGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEVEEDGQLKSLTINGK 17 1 O75190-2 O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 38894700.0 8437700.0 11170000.0 19287000.0 True False 11557345.710268755 10676472.465749552 14731807.828233609 1.0 0.9237823920299847 1.274670516703877 23.46230676703926 -6.849819445340337 1.2359057847534827 0.9593320525173575 1.2886528646067645 0.9400459212883968 0.03689797357420424 0.15765977810657594 0.4635000682473675 0.023362045023203288 0.054056804258552284 1.4131249185571148e-07 6.849819445340337 0.329320812089407 VEVEEDGQLK(ub)SLTINGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEVEEDGQLKSLTINGK 17 1 O75190-2 O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 60127000.0 25722000.0 21407000.0 12998000.0 True False 21388982.67780843 21291676.242043182 15715821.704038259 1.0 0.995450628146695 0.7347624681721675 24.350364529576396 -6.910686265946477 0.891050381275619 1.0078972805144673 0.7005738725589199 0.9911779346192788 0.011644529807701061 0.10396589318719335 0.13631933584747233 0.009566000475554124 0.026533679869625616 1.2283262528204224e-07 6.910686265946477 -0.30732340795554736 VEVEEDGQLK(ub)SLTINGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEVEEDGQLKSLTINGK 17 1 O75190-2 O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 140544000.0 33012000.0 42598000.0 64934000.0 True False 42734684.76380512 40227383.85334851 53116678.27910415 1.0 0.9413286672333145 1.2429406832571803 25.3489041444657 -6.856242661859533 1.2045250332845405 0.96843247649096 1.2565355183345195 0.9489124860122061 0.02951172074435213 0.15072368992149118 0.4176877130048018 0.019135984902623134 0.04449819393719422 1.3923785945982667e-07 6.856242661859533 0.2881030418435595 VEVEEDGQLK(ub)SLTINGVADDDALAEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEVEEDGQLKSLTINGVADDDALAEER 27 1 O75190;A0A0J9YX62;O75190-3;O75190-4 O75190 DNAJB6 DnaJ homolog subfamily B member 6 1 20358700.0 6026700.0 3572000.0 10760000.0 True False 5835385.707348798 4998318.227733919 7941633.2069192175 1.0 0.8565531874678451 1.3609440069947587 22.47639658767129 -6.830734135891616 1.3248407898119614 0.9233928319408262 1.3747006384841869 0.9072939190335755 0.06461060844278736 0.17990944960443045 0.6173535450084793 0.038290378958083196 0.08810554015099684 1.4766102001012642e-07 6.830734135891616 0.45130780654336067 VEVEEDGQLK(ub)SLTINGVADDDALAEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEVEEDGQLKSLTINGVADDDALAEER 27 1 O75190;A0A0J9YX62;O75190-3;O75190-4 O75190 DNAJB6 DnaJ homolog subfamily B member 6 1 22114800.0 6026700.0 5690100.0 10398000.0 True False 5011468.078079007 5659446.301903578 12572173.725080011 1.0 1.1292990823704807 2.508680795568226 22.256801863105565 -6.925160551814537 0.7854842656940003 0.9748433531046011 2.7598708959278873 0.9954989658104118 0.045806626465257044 0.09522931841276716 0.09056442240449562 0.0405876847236825 0.12829075257918138 1.1880629381284372e-07 6.925160551814537 1.7850275428232862 up VEVK(ub)NYDAALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEVKNYDAALR 11 1 Q969X6;H3BSH7;Q969X6-3;Q969X6-2;A0A0J9YWM9;A0A0J9YWK2;A0A0J9YXV4 Q969X6 CIRH1A Cirhin 1 18250500.0 6212600.0 7237100.0 4800800.0 True False 8144778.762903974 6157352.889994856 4304059.268525373 1.0 0.755987740027881 0.5284439754371898 22.957444080598457 -6.971966465819111 0.2058667178270936 1.1255978808812352 0.152510872232154 0.9999939296513894 0.0004743736860690481 0.07566963137860043 0.006695897628494666 0.007042939149975942 0.02380983950594327 1.0666784819548049e-07 6.971966465819111 -0.9730870086490813 VEVK(ub)NYDAALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEVKNYDAALR 11 1 Q969X6;H3BSH7;Q969X6-3;Q969X6-2;A0A0J9YWM9;A0A0J9YWK2;A0A0J9YXV4 Q969X6 CIRH1A Cirhin 1 19701900.0 6544800.0 5589200.0 7567900.0 True False 6337038.906442392 7820996.707292945 5585639.957866533 1.0 1.234172114572616 0.8814274364306067 22.595377442353048 -6.72772173426549 1.7313678662363572 1.1412815572311041 0.8817177753794574 0.5486926644664832 0.09845975956525478 0.3405535222494334 1.9988477492822565 0.04508363115960676 0.11216891396574329 1.871881127601971e-07 6.72772173426549 -0.25956378185164675 VEVK(ub)NYDAALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEVKNYDAALR 11 1 Q969X6;H3BSH7;Q969X6-3;Q969X6-2;A0A0J9YWM9;A0A0J9YWK2;A0A0J9YXV4 Q969X6 CIRH1A Cirhin 1 14699600.0 6212600.0 4116000.0 4371000.0 True False 8509566.109202225 3934141.510208165 3338659.8235707516 1.0 0.4623198715095231 0.3923419573602387 23.020654142121348 -13.999999999999998 0.2874433431397259 5.5670896110240875 0.3727767197179708 0.9996217439348596 0.005279690559454991 15.815530130182841 0.16996681366151706 42.64848560378909 0.026737783703986013 1.0000000000000041e-14 13.999999999999998 -5.194312891306117 VEVK(ub)NYDAALR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEVKNYDAALR 11 1 Q969X6;H3BSH7;Q969X6-3;Q969X6-2;A0A0J9YWM9;A0A0J9YWK2;A0A0J9YXV4 Q969X6 CIRH1A Cirhin 1 21177800.0 6544800.0 7968300.0 6664700.0 True False 5442291.18380066 7925373.186316295 8058257.955908889 1.0 1.456256734278881 1.48067379781053 22.375782717787324 -11.679380296704895 0.4689322689555153 2.6153125473419164e-17 1.4802560816290473 0.9998340523107071 0.002847723600855157 4.749930212250565 0.23233096979494386 4.776793871879416 0.005285632913744701 2.09227951640881e-12 11.679380296704895 1.4802560816290473 VEVRPMMYVALTYDHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEVRPMMYVALTYDHR 16 1 P36957;P36957-2 P36957 DLST Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial 0 35245100.0 7848100.0 10784000.0 16613000.0 False True 11906141.472963834 8859510.944223428 13329433.26826342 1.0 0.7441126887616263 1.1195426577562144 23.50520260640234 -6.723225364208077 1.7478884754748638 0.8448552247529129 1.119057973978618 0.5275650631537591 0.1076383605740783 0.3491124792693946 2.086152900813284 0.048866392550490106 0.12220173614768516 1.8913618979304167e-07 6.723225364208077 0.2742027492257051 VEVRPMMYVALTYDHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEVRPMMYVALTYDHR 16 1 P36957;P36957-2 P36957 DLST Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial 0 36585100.0 7848100.0 14559000.0 14178000.0 False True 10159520.159179064 13748778.851610433 11597749.478564976 1.0 1.3532901786890492 1.1415646897542184 23.276328928494788 -10.188441965291041 4.063380615420146 0.9998857705851855 1.2474274341631626 0.6455042871634261 0.08643656924488552 11800211.871876026 14793829.107896326 10317.774479170945 0.029589533898721834 6.479746782463833e-11 10.188441965291041 0.24754166357797713 VEVTEFEDIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEVTEFEDIK 10 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 91616000.0 15268000.0 41539000.0 34809000.0 False True 20016495.855522305 35341543.11775382 31207298.591505546 1.0 1.765620884536767 1.5590790124684004 24.254686098208516 -10.037291105083042 4.467037040212565 0.9999678061959338 1.662349948552338 0.9320277982389851 0.0843203663974422 11084651.557523329 6226716.198413038 3323.137668713913 0.028865104669834794 9.177172497025326e-11 10.037291105083042 0.6623821423564042 VEVTEFEDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEVTEFEDIK 10 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 81387200.0 24423000.0 7609200.0 49355000.0 False True 23647705.23347429 10647593.241453787 36427444.88173771 1.0 0.45025904781583986 1.5404219784579 24.49519685585597 -6.769603508138681 1.5759157907751935 0.6845228872474498 1.5464694703666058 0.729056144354274 0.23166516116270433 0.26707431981014185 1.3089410667096495 0.11587464554540787 0.2759364359103354 1.6997947825664289e-07 6.769603508138681 0.861946583119156 VEVTEFEDIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEVTEFEDIK 10 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 87945000.0 15268000.0 33960000.0 38717000.0 False True 20912992.20218581 32459534.909297697 29572842.001644667 1.0 1.5521229384815174 1.414089467242939 24.317896159731408 -10.039811373154134 4.53073797804688 0.9999817315764747 1.4831062027517339 0.9423052278069117 0.0563519288050275 19496027.533791095 0.17496842437828913 4385.35297110321 0.019290764081419658 9.124070384774366e-11 10.039811373154134 0.48312447117525914 VEVTEFEDIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEVTEFEDIK 10 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 40692800.0 24423000.0 9151500.0 7118300.0 False True 20308806.622351106 9102199.053069483 8606703.618699469 1.0 0.4481897544414031 0.42379169681133577 24.275602131290245 -13.663931283691344 0.4480889016677904 9.999999998779492 0.42378505713367515 0.9998916001666639 0.0027701156182161277 25.65971321260597 0.2271853076939231 225.84820996504143 0.005534046071166697 2.1680471172582877e-14 13.663931283691344 -9.576214941645818 VEVTEFEDIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEVTEFEDIK 10 0 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 0 20127400.0 1780800.0 11910000.0 6436600.0 False True 2305280.704815951 11247198.030268572 5265204.845093189 1.0 4.878884383481848 2.283975584445605 21.13651100188293 -6.539576165735546 2.4310086339576813 3.7021397241309884 2.2853570503554965 0.0 1.70213133279598 0.8290535680554783 9.160919043166787 0.6044918470190309 1.9314063320731374 2.886847445007095e-07 6.539576165735546 -1.4167826737754918 VEVTEFEDIK(ub)SGYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEVTEFEDIKSGYR 14 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 1 37149000.0 11187000.0 11494000.0 14468000.0 True False 14666265.335062115 9779140.003261087 12970990.146855764 1.0 0.6667777910633083 0.8844098923975201 23.805998209487758 -10.35778503423073 6.6663364196001 1.0000117439381504 0.7755938417304142 0.5863714816407077 0.08884793331975019 1.55085896431618e-05 1.4940888276263119e-06 0.08603114091903086 0.028675547174361635 4.3874781410293565e-11 10.35778503423073 -0.22441790220773616 VEVTEFEDIK(ub)SGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEVTEFEDIKSGYR 14 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 1 72268000.0 23845000.0 24038000.0 24385000.0 True False 23088053.527093083 33636498.75651399 17997836.965680767 1.0 1.4568789316536646 0.7795302858493848 24.46064321388571 -6.725019608971985 1.741480197464233 1.2764612692823925 0.7802917995617068 0.5360090327117741 0.19214736235153645 0.3456453435686207 2.0512314081761667 0.08752381159126366 0.21841220871958916 1.8835640421546086e-07 6.725019608971985 -0.49616946972068565 VEVTEFEDIK(ub)SGYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEVTEFEDIKSGYR 14 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 1 116622000.0 29176000.0 48075000.0 39371000.0 True False 44262125.051310815 39495640.63831055 31589304.593077715 1.0 0.8923123458831965 0.7136870305358781 25.399569381671995 -6.963531779455642 0.3824147244816662 1.0119415366151578 0.5877169106300293 0.9998796046994007 0.0012955801761412385 0.07846279996685317 0.01663893042778313 0.002319186112809044 0.015076460518866809 1.087597549876273e-07 6.963531779455642 -0.42422462598512856 VEVTEFEDIK(ub)SGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEVTEFEDIKSGYR 14 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 1 62779000.0 11187000.0 22683000.0 28909000.0 True False 15323136.217307637 21680790.057349823 22081289.59954403 1.0 1.414905522595378 1.441042439771761 23.86920827101065 -11.808536497865623 0.43930541273958573 4.427363008336257e-10 1.4414444966007869 0.9997965181850103 0.0028819046820463597 5.104731937637052 0.21961572970672213 4.769019084056101 0.006044818409832627 1.5540446842365794e-12 11.808536497865623 1.4414444961580506 VEVTEFEDIK(ub)SGYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEVTEFEDIKSGYR 14 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 1 67367000.0 23845000.0 28345000.0 15177000.0 True False 19828174.01260951 28192299.85895803 18350440.52948061 1.0 1.4218303632512728 0.9254730424400576 24.241048489319986 -6.681565383742077 1.8965113389368018 1.2665219109776573 0.9273461400445699 0.3312558258574486 0.17872082230348654 0.43503395708896847 3.0266013562120238 0.07558252848094052 0.19893141118075688 2.0817789664100051e-07 6.681565383742077 -0.3391757709330874 VEVTEFEDIK(ub)SGYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEVTEFEDIKSGYR 14 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;A0A087X027;P0DME0;Q01105 Q01105-2;Q01105 SET;SETSIP Protein SET;Protein SETSIP 1 115580000.0 29176000.0 53294000.0 33110000.0 True False 37768907.14494056 50328142.05080892 27084319.73728919 1.0 1.3325284170302176 0.7171062597430051 25.170695703764444 -6.75993489478263 1.6124975853449663 1.1931651562361247 0.7148479019492542 0.690782797437749 0.13986196933408843 0.28302828476033853 1.4503690657015913 0.06843291077532598 0.16447991993016492 1.7380613625260156e-07 6.75993489478263 -0.47831725428687055 VEVVSPLSSWK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEVVSPLSSWKR 12 1 Q9H490-2;Q9H490 Q9H490-2 PIGU Phosphatidylinositol glycan anchor biosynthesis class U protein 1 26119000.0 1703400.0 3359600.0 21056000.0 True False 2233173.8957490674 2858360.775618233 18877327.103414103 1.0 1.2799544097569977 8.453137993126207 21.090664166551147 -6.915132745423368 0.8600363102123724 0.8123060731990625 9.489657100554687 0.9927188838765849 0.29433124866997673 0.10112123910092023 0.12107586265628749 0.2472638090083976 0.7094710892984545 1.2158143209183763e-07 6.915132745423368 8.677351027355625 up VEVVSPLSSWK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEVVSPLSSWKR 12 1 Q9H490-2;Q9H490 Q9H490-2 PIGU Phosphatidylinositol glycan anchor biosynthesis class U protein 1 53285600.0 1766500.0 7308100.0 44211000.0 True False 1710423.4244332148 10226262.441238044 32630812.798429884 1.0 5.9787899856590965 19.077622729145443 20.705922085494645 -6.954358964139827 0.5087483149917429 0.7564236143797054 24.873426155366946 0.9995004302730337 0.17041094147724947 0.08178126202973429 0.02907365755134506 0.19670682100570153 1.0809900304284956 1.1108132101008565e-07 6.954358964139827 24.11700254098724 VEVVSPLSSWK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEVVSPLSSWKR 12 1 Q9H490-2;Q9H490 Q9H490-2 PIGU Phosphatidylinositol glycan anchor biosynthesis class U protein 1 35095910.0 1703400.0 3260300.0 30132210.0 True False 2333193.012654138 3116249.1656296607 23015602.59034476 1.0 1.335615677197984 9.864422902657 21.153874228074038 -6.91519851359633 0.8595840272321277 0.7773357736483285 11.09856340110539 0.9927398898549158 0.34950871467714656 0.10107978678560291 0.12086349896385915 0.2937169358438951 0.8431941514669522 1.2156302158109013e-07 6.91519851359633 10.321227627457061 up VEVVSPLSSWK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEVVSPLSSWKR 12 1 Q9H490-2;Q9H490 Q9H490-2 PIGU Phosphatidylinositol glycan anchor biosynthesis class U protein 1 46597500.0 1766500.0 9756000.0 35075000.0 True False 1468923.019218904 9703442.491585612 42409020.33152345 1.0 6.605820975387392 28.870825616222106 20.48632736092892 -6.945037355309283 0.6109036626356842 0.7540353926180975 35.883904036249774 0.9987520281504011 0.4252161074595152 0.08554181702229452 0.04469616455832556 0.4318536314858175 1.878041176815003 1.1349131933021444e-07 6.945037355309283 35.129868643631674 VEYHFLSPYVSPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEYHFLSPYVSPK 13 0 P02786;G3V0E5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 0 8966300.0 2188100.0 2966100.0 3812100.0 False True 2868620.2895905445 2523569.4417672455 3417660.460245289 1.0 0.8797153986969289 1.1913952057883241 21.451925584980835 -6.80211779021427 1.4476660260049734 0.9338107149916663 1.195905154285173 0.8381609467705128 0.05163095519653244 0.21775680988773352 0.9008003539268984 0.028057089721345574 0.06515591637663933 1.577183444849378e-07 6.80211779021427 0.26209443929350673 VEYHFLSPYVSPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEYHFLSPYVSPK 13 0 P02786;G3V0E5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 0 7343500.0 2188100.0 2577100.0 2578300.0 False True 2997099.701179123 2463235.2006699345 1969358.6417553108 1.0 0.8218729592815498 0.6570881312291756 21.515135646503726 -6.972059599048449 0.2030529413907862 1.0943019280777666 0.38009431008404615 0.9999943026001261 0.0003341873384655388 0.0756398826394836 0.006581125106020618 0.00521799524096556 0.017361160355731375 1.0664497602817153e-07 6.972059599048449 -0.7142076179937205 VEYHFLSPYVSPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEYHFLSPYVSPK 13 0 P02786;G3V0E5 P02786 TFRC Transferrin receptor protein 1;Transferrin receptor protein 1, serum form 0 841530.0 841530.0 0.0 0.0 False True 699769.481100075 0.0 0.0 1.0 0.0 0.0 19.416520220429714 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 VEYSEEELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEYSEEELK 9 0 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 0 7715170.0 1840900.0 818270.0 5056000.0 False True 1782461.637157716 1145009.4782216777 3731681.923251258 1.0 0.6423753837684221 2.0935552527243932 20.76543959607586 -6.841514238744246 1.275345940922077 0.8097750863048949 2.142734119981287 0.9270272437632191 0.1667577449562485 0.16703665952830796 0.5270977815650233 0.10250253332999519 0.23625021876442398 1.4404087843446874e-07 6.841514238744246 1.3329590336763921 up VEYSEEELK(ub)THISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEYSEEELKTHISK 14 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 11429200.0 3413100.0 4782500.0 3233600.0 True False 4474607.152507413 4068969.6420389866 2899018.0908814464 1.0 0.9093467880769999 0.6478821474320797 22.09332959605684 -6.952331848145161 0.5326279841069769 1.0040474366865368 0.5412585092055502 0.9993718061498436 0.003741594319711513 0.08256267084614896 0.03218999393556589 0.004158311128161652 0.021629309624836664 1.1160101689405775e-07 6.952331848145161 -0.46278892748098666 VEYSEEELK(ub)THISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEYSEEELKTHISK 14 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 8907800.0 1939600.0 2721600.0 4246600.0 True False 1878028.4596833629 3808349.072956509 3134288.064730776 1.0 2.027844175268036 1.6689246899161578 20.84078749511296 -10.090357216466899 4.421633467434343 0.999925439789739 1.848384432589172 0.8816505030341701 0.1465282665489877 21516245.96684026 16367010.299503041 14898.26479574238 0.050160525540961884 8.121622206231324e-11 10.090357216466899 0.848458992799433 VEYSEEELK(ub)THISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VEYSEEELKTHISK 14 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 31078900.0 6024300.0 6585600.0 18469000.0 True False 9139303.535323974 5410348.226472352 14818594.05474972 1.0 0.5919869282775236 1.621413929133105 23.12365279758144 -6.7991521111822015 1.459268539610281 0.7746410368701802 1.6353479440150285 0.8297145386965381 0.17466149617985466 0.2219610982136436 0.9332139240539523 0.09416282868764625 0.21911218359822238 1.587990459207537e-07 6.7991521111822015 0.8607069071448483 VEYSEEELK(ub)THISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEYSEEELKTHISK 14 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 8501000.0 3413100.0 2020000.0 3067900.0 True False 4675015.305559365 1930749.7207532753 2343325.20538383 1.0 0.4129932405691368 0.5012443922049259 22.15653965757973 -10.75323670312125 7.018466060452667 1.0100647957292481 0.45711881638703133 0.9805656888447216 0.03602838178677805 0.0056302212653822105 0.00019795353705047368 0.03461481881679987 0.011628110220916171 1.7650755409792725e-11 10.75323670312125 -0.5529459793422168 VEYSEEELK(ub)THISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VEYSEEELKTHISK 14 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 8856000.0 1939600.0 3707000.0 3209400.0 True False 1612863.3388491273 3687029.6552181095 3880470.7014110233 1.0 2.286014919186533 2.4059513338433045 20.621192770547236 -10.675812945286054 0.4560588389452144 4.435687140400876e-11 2.406860417996273 0.9995635473172645 0.013295087050054792 2.204627369115723 0.21819865626642193 2.4966168968201137 0.026631102526069074 2.1095365515044393e-11 10.675812945286054 2.406860417951916 VEYSEEELK(ub)THISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VEYSEEELKTHISK 14 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 57173000.0 6024300.0 6704700.0 44444000.0 True False 7798575.106706398 6331577.551095023 36355648.03394992 1.0 0.8118890264517902 4.661832134268454 22.89477911967389 -6.895414450086276 0.9897984293811342 0.819176128888007 5.0303407461719 0.984143419193117 0.22316148675046013 0.11486054068719448 0.19706472469270953 0.17044782138957748 0.43410678428489985 1.272288348339377e-07 6.895414450086276 4.2111646172838935 up VEYTLGEESEAPGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VEYTLGEESEAPGQR 15 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;H7C0V6 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 14694480.0 956480.0 5353900.0 8384100.0 False True 1253954.5425654966 4555118.989338746 7516593.757966095 1.0 3.632602965031982 5.994311199341971 20.25805361889633 -7.39312314690291 0.24413109680479056 7.555834511948648e-26 8.698099794737596 0.9999143241865186 0.01888173600264087 0.12461629695370806 0.020565774480468847 0.1703006866062573 0.45560684450724903 4.0446118794897005e-08 7.39312314690291 8.698099794737596 VEYTLGEESEAPGQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VEYTLGEESEAPGQR 15 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;H7C0V6 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 8820950.0 1765300.0 653050.0 6402600.0 False True 1709261.5177763675 913816.2706107596 4725566.98611719 1.0 0.5346263641385738 2.7646834243743053 20.704941716212304 -6.852236972119317 1.224218219594995 0.7511011940504723 2.8577720380134584 0.9435054201005936 0.22830818662282784 0.15500895376384347 0.44592095382196095 0.14584196383658277 0.33801119954619885 1.405280525725259e-07 6.852236972119317 2.106670843962986 up VEYTLGEESEAPGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VEYTLGEESEAPGQR 15 0 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;H7C0V6 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 14703880.0 956480.0 6422600.0 7324800.0 False True 1310116.503900099 6138828.295301986 5594833.098991319 1.0 4.685711749319427 4.270485168560203 20.32126368041922 -10.154750037191725 4.684453638429813 0.9996182249738894 4.478098458973211 0.9894237876450732 0.16951554186452464 29659276.51424615 90.7507926334395 122135.84001351957 0.058029678812145415 7.002449134472752e-11 10.154750037191725 3.4784802339993215 VFAAEALLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFAAEALLK 9 0 Q9HC52 Q9HC52 CBX8 Chromobox protein homolog 8 0 89566000.0 24839000.0 24251000.0 40476000.0 False True 37682578.97414006 19923219.57607216 32475900.858739 1.0 0.5287116784056795 0.8618279784147953 25.16739436976412 -10.100664558890115 6.033853351613713 1.000001141451047 0.6952698284102309 0.5273606703883507 0.13599416000439515 2.0882753960902896e-06 3.112049135740327e-07 0.13167627167976115 0.043891926406536934 7.931136804582415e-11 10.100664558890115 -0.30473131304081613 VFAAEALLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFAAEALLK 9 0 Q9HC52 Q9HC52 CBX8 Chromobox protein homolog 8 0 29847900.0 14753000.0 3936900.0 11158000.0 False True 12267773.168715796 3915691.1382865366 13491086.211237054 1.0 0.31918515972173256 1.0997176118026737 23.548370060725794 -6.676201747563924 1.9155337968847859 0.5677714435893808 1.0966525274235068 0.3067260294395522 0.28878984863850005 0.4470386094549189 3.1680092235726818 0.1211252774920604 0.3210049805908623 2.107648833328599e-07 6.676201747563924 0.528881083834126 VFAAEALLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFAAEALLK 9 0 Q9HC52 Q9HC52 CBX8 Chromobox protein homolog 8 0 53606000.0 24839000.0 20542000.0 8225000.0 False True 32154575.14988962 19398819.64213075 6728134.395626809 1.0 0.6032988945337486 0.20924345491313096 24.93852069185657 -7.6281771118958215 0.35303086017635116 1.0631014402926777 4.565381453640691e-12 0.9991408558909047 0.009462391393658877 0.12322105988239322 0.048118727185614975 0.02656846345478421 0.07305578342027022 2.3540890547864487e-08 7.6281771118958215 -1.0631014402881123 down VFANILLYIQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFANILLYIQR 11 0 B0QY89;Q9Y262;Q9Y262-2;B0QY90 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 47194000.0 13552000.0 13474000.0 20168000.0 False True 20559374.78391024 11069459.42715751 16181785.960051576 1.0 0.5384142048823617 0.7870757807633059 24.293293056668084 -10.063330957118236 5.170071550382477 1.000004845208111 0.6627449928219852 0.7103686339581939 0.1015156632604058 5.6695014112651525e-06 1.0271234535604196e-06 0.09829353064328596 0.032764039431803636 8.643090150746216e-11 10.063330957118236 -0.33725985238612577 VFANILLYIQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFANILLYIQR 11 0 B0QY89;Q9Y262;Q9Y262-2;B0QY90 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 31960700.0 13552000.0 7881700.0 10527000.0 False True 17543331.14985726 7443076.466428867 8611194.01614144 1.0 0.4242681394342503 0.4908528455960603 24.064419378760533 -10.308860920644284 5.6820772828266985 1.0000641572367897 0.457560492516606 0.9888255206129087 0.027183092461614416 2.20955103637599e-05 2.6875835419024194e-06 0.02632300994589509 0.008773305366851636 4.9106511067302905e-11 10.308860920644284 -0.5425036647201836 VFASELNAGIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFASELNAGIIK 12 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;Q9P2J5-3 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 8228600.0 2489100.0 2550200.0 3189300.0 False True 3263234.2044786853 2169720.1006017416 2859301.829925841 1.0 0.6648986755605435 0.8762171670061377 21.637871103647768 -10.452528283149155 5.861332111056101 1.0001418271953606 0.7705579212833404 0.6111741617442117 0.08627041287606671 0.0001599876164509597 1.494343908224712e-05 0.0835822948715567 0.027843656028286968 3.5275381300533873e-11 10.452528283149155 -0.22958390591202016 VFASELNAGIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFASELNAGIIK 12 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;Q9P2J5-3 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 6824700.0 2489100.0 1955300.0 2380300.0 False True 3409387.535398264 1868908.3806875672 1818122.1638173107 1.0 0.5481654289174999 0.5332694347417237 21.70108116517066 VFDAIMNFK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VFDAIMNFK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 148363900.0 39815700.0 47004000.0 61544200.0 False True 52198768.27578728 39991186.42015697 55176196.557652764 1.0 0.7661327602380826 1.0570402019092582 25.637512428413228 -6.692738224806401 1.8571164953268837 0.8537553927411402 1.056057756400934 0.3831207954162251 0.09885528814585814 0.41078501143561735 2.7490152477573933 0.04255461256216596 0.11041666497407426 2.028905293286896e-07 6.692738224806401 0.2023023636597937 VFDAIMNFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFDAIMNFK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 81720000.0 30317000.0 12907000.0 38496000.0 False True 29354603.42968681 18060832.40911582 28412742.744754866 1.0 0.6152640573863312 0.9679143788405118 24.807083430729165 -10.412515647220388 8.51010656390701 1.0000020862471508 0.7915892194695755 0.31772430288145026 0.143968890865201 5.698714133881157e-06 3.9347137765425175e-07 0.1393986748168352 0.04646575972440639 3.8679811841077056e-11 10.412515647220388 -0.2084128667775753 VFDAIMNFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFDAIMNFK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 112819000.0 19647000.0 69754000.0 23418000.0 False True 29805935.388096496 57305853.70951044 18789422.035525955 1.0 1.9226322866014296 0.6303919602211118 24.829096313768986 -6.714987414603482 1.7771632397091344 1.5642887267803107 0.6329204871005704 0.4888860306653732 0.3885029460893395 0.36512933644997525 2.2508201437231836 0.17376074721729556 0.43882835141010806 1.9275807716414583e-07 6.714987414603482 -0.9313682396797404 VFDAIMNFK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VFDAIMNFK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 127554200.0 39815700.0 40927000.0 46811500.0 False True 54536640.26883484 39118709.81250962 35755587.81310505 1.0 0.717292257456207 0.6556250556845855 25.70072248993612 -13.999999999999998 0.21398201191975685 2.6623553749024347 0.6206749029520853 0.9994926171166253 0.0033772723464383725 12.842863349338424 0.14658969525036317 8.99344327234581 0.03553557157755287 1.0000000000000041e-14 13.999999999999998 -2.0416804719503494 VFDAIMNFK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VFDAIMNFK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 65627000.0 34256700.0 15189200.0 16181100.0 False True 28485963.879126064 15107372.764779875 19564493.19704677 1.0 0.5303444471419221 0.6868116971594995 24.763747887696155 -10.33843666232249 5.37176292223093 1.0001093663563938 0.6085780721506984 0.892981177566395 0.06387748733330172 8.368944906929814e-05 1.0306691539136298e-05 0.06186627803703358 0.020616370386614714 4.587365432372262e-11 10.33843666232249 -0.39153129420569543 VFDAIMNFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFDAIMNFK 9 0 P13639 P13639 EEF2 Elongation factor 2 0 84040000.0 19647000.0 41704000.0 22689000.0 False True 25433428.800268956 39383135.73923774 18559834.808799583 1.0 1.5484792101181917 0.7297417487257288 24.600222635861435 -6.726177380754548 1.7371544678639823 1.3314654079130686 0.7305551438742458 0.5414941526782431 0.23064446045227915 0.3434347649107538 2.028541761277783 0.10529408742532408 0.262419857390258 1.8785493961211654e-07 6.726177380754548 -0.6009102640388228 VFDAIMNFKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFDAIMNFKK 10 1 P13639 P13639 EEF2 Elongation factor 2 1 26475000.0 2004800.0 9909200.0 14561000.0 True False 3041428.1705123354 8140825.839067029 11683011.967686992 1.0 2.676645767273106 3.8412914304397208 21.53631750177038 -8.086989211194734 0.21253993655975909 1.802150302229381e-16 5.196833871867792 0.999757020570278 0.018178693122673888 0.09561161347246803 0.041729074363869995 0.3707828494006621 0.4565321703557945 8.184851208059764e-09 8.086989211194734 5.196833871867792 VFDFTFSPEEMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFDFTFSPEEMK 12 0 P14550 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 5104200.0 1131600.0 2177400.0 1795200.0 False True 1483538.55842999 1852540.4074387252 1609449.9247743608 1.0 1.248730878555152 1.0848723247730219 20.50061099350185 -10.495139504510528 4.012517862641981 0.9984280523162031 1.1668016016658644 0.5801246448394441 0.06689497446612536 48386420.317219965 1284.2623838900195 702738.084853181 0.022899905597392606 3.1978677224030903e-11 10.495139504510528 0.1683735493496613 VFDFTFSPEEMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFDFTFSPEEMK 12 0 P14550 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 5470800.0 1748400.0 1501900.0 2220500.0 False True 1692897.9990257742 2101616.502305033 1638884.4364278903 1.0 1.241431263735008 0.9680940241946251 20.691063619502298 -6.6735734868850205 1.9251475667636648 1.1536300237328088 0.9691897232302925 0.29485992072124656 0.10247117745783027 0.45291460577559756 3.239607416214286 0.042804352612350716 0.11381388880986863 2.120442563057485e-07 6.6735734868850205 -0.18444030050251625 VFDFTFSPEEMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFDFTFSPEEMK 12 0 P14550 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 6546600.0 1131600.0 2502000.0 2913000.0 False True 1549983.1003401566 2391453.3669924242 2225009.3951181895 1.0 1.5428899621341678 1.4355055836608108 20.563821055024743 -10.123875679789158 4.94102745384666 0.9999770634019473 1.4891977728993393 0.9651215980027517 0.0438394889406742 1.1077319236897687e-05 1.9641590229490953e-06 0.04244939028416687 0.014149134213542056 7.51838082780831e-11 10.123875679789158 0.48922070949739205 VFDHK(ub)QGTYGGYFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFDHKQGTYGGYFR 14 1 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 36022200.0 5019500.0 9261500.0 21741200.0 True False 6580613.108907142 7879720.301044243 19491629.180316605 1.0 1.197414309371676 2.9619776847135793 22.649790573949318 -6.928092843329914 0.7622806992998382 0.971182134527991 3.307249727854106 0.9961500154593059 0.0547292736457841 0.09364029372682404 0.08261979373235508 0.049306652811551596 0.16136939510284717 1.1800683340681985e-07 6.928092843329914 2.3360675933261152 up VFDHK(ub)QGTYGGYFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFDHKQGTYGGYFR 14 1 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 63784700.0 11911000.0 7567700.0 44306000.0 True False 11532891.824751772 10589522.075034149 32700929.448490996 1.0 0.9182018036713938 2.8354492477167437 23.459250972355278 -6.896934674602197 0.9804525225496484 0.9134461159175673 3.024618481083394 0.9849782930575008 0.10848661146774972 0.11369660160498288 0.19042199509612728 0.08344347259525346 0.21394986199087748 1.267842556953849e-07 6.896934674602197 2.1111723651658263 up VFDHK(ub)QGTYGGYFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFDHKQGTYGGYFR 14 1 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 65436600.0 5019500.0 12572100.0 47845000.0 True False 6875344.796887064 12016623.05162488 36544996.3987057 1.0 1.7477847884902618 5.315369261953538 22.71300063547221 -6.940856872898909 0.6515425796372547 0.9604714457529147 6.302181072388454 0.9982740011834497 0.07822711415311022 0.08737787494322584 0.05284562781913264 0.07665202734538822 0.3059141160433485 1.1458905215735245e-07 6.940856872898909 5.34170962663554 VFDHK(ub)QGTYGGYFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFDHKQGTYGGYFR 14 1 Q99613-2;Q99613;B5ME19 Q99613-2 EIF3C;EIF3CL Eukaryotic translation initiation factor 3 subunit C;Eukaryotic translation initiation factor 3 subunit C-like protein 1 100546000.0 11911000.0 43066000.0 45569000.0 True False 9904524.246768383 42833994.91006832 55097267.212749675 1.0 4.324689792550516 5.562838339330295 23.239656247789554 -9.126622719781977 0.3599016159518356 1.891927497031285e-19 5.875749430544076 0.9980676844398597 0.08468967155956035 0.5518427208460209 0.133632294840548 1.1333414458888238 0.34746372061771347 7.470974949749398e-10 9.126622719781977 5.875749430544076 VFDK(ub)DGNGYISAAELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFDKDGNGYISAAELR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2 P0DP25 CALM2;CALM1 1 35373000.0 7198000.0 10825000.0 17350000.0 True False 9436647.705531165 9209952.195519501 15554788.432951842 1.0 0.9759771142162286 1.6483383631916884 23.16984301391769 -6.89861601146081 0.9700000344886185 0.9709732411122558 1.7169573419123514 0.9858639909659555 0.03702939595877812 0.11243125293279498 0.1832331265567657 0.028704614128314675 0.07417726080555348 1.2629436933180252e-07 6.89861601146081 0.7459841008000956 VFDK(ub)DGNGYISAAELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFDKDGNGYISAAELR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2 P0DP25 CALM2;CALM1 1 53124000.0 10224000.0 13961000.0 28939000.0 True False 9899444.71633466 19535700.10565319 21359007.748609237 1.0 1.973413728289037 2.1575965481544266 23.238916172550987 -10.760681558920409 0.32712034182369054 1.0412643249297206e-09 2.199975731036997 0.9992138861226741 0.01423982340156694 2.435851228272054 0.16149834269130317 1.973886546154404 0.05938405929109287 1.7350757543729512e-11 10.760681558920409 2.1999757299957325 VFDK(ub)DGNGYISAAELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFDKDGNGYISAAELR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2 P0DP25 CALM2;CALM1 1 100378000.0 18074000.0 38564000.0 43740000.0 True False 27419579.386392657 31681952.89809272 35094769.82807692 1.0 1.1554499962102018 1.2799164178825144 24.708703104700678 -6.9736416871749505 0.1471391799950189 0.8493798294121986 1.589252260055811 0.9999986604511748 0.00013240505161468536 0.07513778825101532 0.004485262595125721 0.006537419422377213 0.015712121448824622 1.0625718660745382e-07 6.9736416871749505 0.7398724306436124 VFDK(ub)DGNGYISAAELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFDKDGNGYISAAELR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2 P0DP25 CALM2;CALM1 1 37011000.0 7198000.0 11121000.0 18692000.0 True False 9859295.118635954 10629637.447770897 14277334.573823964 1.0 1.0781336109595552 1.448109058713241 23.23305307544058 -6.941026618541133 0.6499463193552993 0.9959095130638038 1.5509655265492215 0.9982952562091161 0.008069633597746411 0.08730145079559212 0.052500906876574924 0.007917669374719062 0.03170178758180262 1.1454427334410737e-07 6.941026618541133 0.5550560134854177 VFDK(ub)DGNGYISAAELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFDKDGNGYISAAELR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2 P0DP25 CALM2;CALM1 1 40323000.0 10224000.0 15856000.0 14243000.0 True False 8501708.99999664 15770580.580830434 17221145.447808683 1.0 1.8549894592765606 2.0256098447753845 23.019321447985263 -10.904455239094029 0.30889338063240346 2.1212861578831047e-12 2.0723393840912374 0.999231302450301 0.012440413216813316 2.7018905429186866 0.15603009189187328 2.0117955776046714 0.05912487502364472 1.2460766585339555e-11 10.904455239094029 2.072339384089116 VFDK(ub)DGNGYISAAELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFDKDGNGYISAAELR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2 P0DP25 CALM2;CALM1 1 107665000.0 18074000.0 43283000.0 46308000.0 True False 23397149.291803405 40874263.00118514 37880419.16020498 1.0 1.7469762017334478 1.619018568791003 24.479829426793128 -10.163379453137441 4.492720771224638 0.9998859978909981 1.68299738527876 0.9743509665278747 0.052238485034916814 36590681.57214653 10.291057330535914 45061.9207210721 0.01788262286881359 6.864683945959209e-11 10.163379453137441 0.683111387387762 VFDK(ub)LSPLHER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFDKLSPLHER 11 1 A2ACR1;P28065-2;P28065;A2ACR0 A2ACR1 PSMB9 Proteasome subunit beta type;Proteasome subunit beta type-9 1 12005600.0 2414300.0 4758900.0 4832400.0 True False 3662669.608972432 3909637.113544586 3877274.0218838337 1.0 1.0674282779880442 1.0585923481565702 21.804464137966978 -10.093934045427133 4.156330289867434 0.9999896867286698 1.063010313087892 0.9854659959726476 0.0036072533103591736 2509451.9671146083 0.03366705148296935 259.42037128660445 0.0012348587462229956 8.055007601023511e-11 10.093934045427133 0.06302062635922223 VFDK(ub)LSPLHER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFDKLSPLHER 11 1 A2ACR1;P28065-2;P28065;A2ACR0 A2ACR1 PSMB9 Proteasome subunit beta type;Proteasome subunit beta type-9 1 9514600.0 2414300.0 3717900.0 3382400.0 True False 3125358.94296785 3510995.596703237 2766837.906354789 1.0 1.1233895564549732 0.8852864444835229 21.575590460059427 -6.765887809789643 1.5904368369860118 1.0711450262363067 0.8841580050561324 0.7144905205926753 0.05195122510230303 0.2731341481808528 1.3628653851574006 0.025758478895500328 0.06154406472398631 1.7144001270187437e-07 6.765887809789643 -0.1869870211801743 VFDKDGNGYISAAELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFDKDGNGYISAAELR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2 P0DP25 CALM2;CALM1 0 100212400.0 9564000.0 47311400.0 43337000.0 False True 12538496.617907735 40252723.538392745 38852902.957857884 1.0 3.2103309324104288 3.0986891125661256 23.579861041704586 -10.261760116850462 6.526498505530938 0.9999672488145315 3.1545100224882776 0.9979902393389891 0.04557758209571282 2.1720307529335963e-05 2.4569416113653033e-06 0.04413096403261183 0.014710101368091224 5.473181913677784e-11 10.261760116850462 2.154542773673746 VFDKDGNGYISAAELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFDKDGNGYISAAELR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2 P0DP25 CALM2;CALM1 0 53790100.0 16681000.0 6548100.0 30561000.0 False True 16151470.78571775 9162790.477890396 22556157.289652247 1.0 0.5673037830085896 1.3965389027975066 23.945162209851865 -6.764895482297948 1.5938210791018859 0.7501984964722773 1.4003472411718907 0.7106915017897086 0.18214624808711738 0.27477919078842206 1.376670013213411 0.0901212099389538 0.21556102477995248 1.7183218702934108e-07 6.764895482297948 0.6501487446996134 VFDKDGNGYISAAELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFDKDGNGYISAAELR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2 P0DP25 CALM2;CALM1 0 293614400.0 5209800.0 281551000.0 6853600.0 False True 7903647.48739784 231306024.28199625 5498982.95596041 1.0 29.265731379190136 0.6957525578827237 22.914087171671333 -3.06413402657802 15.945713420303413 9.999999999972573 11.94486078017236 0.0 13.400714235185502 0.0 0.0 4.22196355236628 0.0 0.0008627122671181923 3.06413402657802 1.9448607801997877 VFDKDGNGYISAAELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFDKDGNGYISAAELR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2 P0DP25 CALM2;CALM1 0 60723000.0 9564000.0 23778000.0 27381000.0 False True 13100069.25738178 22727409.336669035 20914171.729396176 1.0 1.734907571107865 1.596493218355408 23.643071103227477 -10.085417132510955 5.04235292710726 0.999983721033042 1.6657003947340252 0.9685943474371295 0.056507422895147465 1.034150716999073e-05 1.8756733731592468e-06 0.054714412037435996 0.01823769231631214 8.214532789258898e-11 10.085417132510955 0.6657166737009832 VFDKDGNGYISAAELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFDKDGNGYISAAELR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2 P0DP25 CALM2;CALM1 0 24293400.0 16681000.0 4529600.0 3082800.0 False True 13870990.593597788 4505198.145744792 3727399.226743279 1.0 0.32479281961478546 0.2687190364373598 23.725567485286142 -13.999999999999998 0.35254256831592623 9.434946618913774 0.26123071093651495 0.9997595235047451 0.0051531032266266905 20.91570066977301 0.19131949881594468 132.27848573621122 0.016586597235139815 1.0000000000000041e-14 13.999999999999998 -9.17371590797726 VFDKDGNGYISAAELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFDKDGNGYISAAELR 16 1 P0DP25;P0DP24;P0DP23;E7EMB3;Q96HY3;G3V361;A0A590UJI2 P0DP25 CALM2;CALM1 0 27099000.0 5209800.0 12738000.0 9151200.0 False True 6744188.800511091 12029119.102398073 7485775.499241334 1.0 1.7836272764912033 1.1099593621510186 22.685213493763783 -10.254462637228135 4.422848223318902 0.9997881213763544 1.4467933193232159 0.36967757613501195 0.27502377449784404 30486460.05865521 70683714.14893523 42605.10624943167 0.09414795531020632 5.5659251638792e-11 10.254462637228135 0.44700519794686144 VFDKEGNGTVMGAELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFDKEGNGTVMGAELR 16 1 P05976-2;P05976;P08590 P05976-2 MYL1;MYL3 Myosin light chain 1/3, skeletal muscle isoform;Myosin light chain 3 0 11844500.0 2390500.0 3637000.0 5817000.0 False True 3133968.649634928 3094373.77691496 5215112.640604096 1.0 0.9873659001902969 1.6640602455329596 21.579559317340653 -6.9026500061697265 0.9443965177758555 0.9738738731458733 1.7390315969632313 0.9878380911744833 0.03485553420104849 0.10948032994562987 0.16663775477143206 0.02753773771570251 0.07264689013689533 1.251267008293479e-07 6.9026500061697265 0.765157723817358 VFDKEGNGTVMGAELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFDKEGNGTVMGAELR 16 1 P05976-2;P05976;P08590 P05976-2 MYL1;MYL3 Myosin light chain 1/3, skeletal muscle isoform;Myosin light chain 3 0 14494900.0 2390500.0 5350600.0 6753800.0 False True 3274332.4508334547 5114192.79993192 5158691.538877175 1.0 1.56190395347001 1.5754941247838388 21.642769378863544 -11.401314949319971 0.6011117623303437 4.164233242747236e-15 1.5738251587128171 0.9999480867661599 0.0019319964496266036 4.200558854367017 0.2988447013344545 5.542330431907124 0.0023612609228883742 3.969036115259382e-12 11.401314949319971 1.573825158712813 VFDLQFSTDSPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFDLQFSTDSPR 12 0 E9PHA2;Q15003;C9J470;C9JZP1 E9PHA2 NCAPH Condensin complex subunit 2 0 6360100.0 2144700.0 1720700.0 2494700.0 False True 2811722.4693043474 1463978.267236068 2236572.3748521637 1.0 0.5206695480149124 0.7954456384898889 21.423022769738182 -10.191406879684966 5.5937890377287784 1.0000102530631376 0.6580575932523798 0.673718885044195 0.11217686919682994 1.4344165003488319e-05 2.0735084979229618e-06 0.1086180410877356 0.036204928852406344 6.435660419885789e-11 10.191406879684966 -0.34195265981075784 VFDLQFSTDSPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFDLQFSTDSPR 12 0 E9PHA2;Q15003;C9J470;C9JZP1 E9PHA2 NCAPH Condensin complex subunit 2 0 7472500.0 2144700.0 2143700.0 3184100.0 False True 2937653.5483382237 2048984.2457320795 2432081.15859795 1.0 0.6974900926935894 0.8278992463130083 21.486232831261074 -10.162448754049976 4.666803544143906 1.0000286071174591 0.7626946695021722 0.8153301709039953 0.05323931403524256 74576603.91549881 1.3252689320827473 23466.97181518067 0.01822523327559699 6.879410833021318e-11 10.162448754049976 -0.23733393761528687 VFDLQFSTDSPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFDLQFSTDSPR 12 0 E9PHA2;Q15003;C9J470;C9JZP1 E9PHA2 NCAPH Condensin complex subunit 2 0 5902400.0 3567900.0 2334500.0 0.0 False True 2966866.934769955 2321923.58513803 0.0 1.0 0.7826180399014313 0.0 21.500508792113887 -7.278502994483331 0.832892405274579 0.9890093419628923 1.2396650622878828e-17 0.9885109607774257 0.04603004525657275 0.10157641532191362 0.13762485705819072 0.03913933144754129 0.0691058715427032 5.2661958381160715e-08 7.278502994483331 -0.9890093419628923 down VFDMLNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFDMLNR 7 0 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 6035830.0 2797500.0 807830.0 2430500.0 False True 2708694.8937740778 1130400.7317777968 1793879.1365629323 1.0 0.41732301942755434 0.6622669613643659 21.369166467467746 -10.324308955408911 5.783915547870062 1.000056860595474 0.5397949903959668 0.8247645485969071 0.0999979455551898 7.332969388741752e-05 8.566557791220775e-06 0.09683450103775583 0.03227419814918287 4.739047313272758e-11 10.324308955408911 -0.46026187019950726 VFDPVPVGVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFDPVPVGVTK 11 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 19306800.0 2115300.0 9714500.0 7477000.0 False True 2773178.7845943393 8265134.466824425 6703351.764448473 1.0 2.9803828417912297 2.4172086566099416 21.40310919808279 -10.004675356775516 5.052166844721045 0.9999851712296943 2.698795749211207 0.9238506533221215 0.2299148983861383 4.119451855114639e-05 8.116278017150314e-06 0.22261622172743792 0.07420471436701079 9.8929233279368e-11 10.004675356775516 1.6988105779815126 VFDPVPVGVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFDPVPVGVTK 11 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 14560500.0 4452100.0 2099600.0 8008800.0 False True 4310770.522456329 2937981.229269359 5911055.021150065 1.0 0.681544335047383 1.3712293406381266 22.039514334131 -6.781125557650758 1.531256672458136 0.819949956124714 1.3769105304077347 0.7714465061327942 0.1347387403923735 0.24881849001618855 1.1523918863551479 0.06929647679149213 0.1633730730525122 1.6552913376834364e-07 6.781125557650758 0.5569605742830207 VFDPVPVGVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFDPVPVGVTK 11 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 15264900.0 2115300.0 6507400.0 6642200.0 False True 2897383.5738330944 6219881.550905874 5073449.160403034 1.0 2.146723549853387 1.7510450484438664 21.466319259605683 -10.325944592767115 6.251434577392409 0.9999420078607792 1.9488842991486082 0.8846327208642348 0.16153507177374107 0.00013057947516110377 1.4079562655891227e-05 0.15641511126801158 0.05213522023400978 4.721232708462708e-11 10.325944592767115 0.9489422912878289 VFDPVPVGVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFDPVPVGVTK 11 0 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 10365900.0 3922100.0 3931300.0 2512500.0 False True 5077235.766149282 3712519.6991095594 2055250.780427034 1.0 0.731208844753971 0.40479719183609897 22.275611823828765 -6.968529771893101 0.2911720102128712 1.0628911735215856 0.06301361016129634 0.9999685337278192 0.0013651658253962908 0.07678272840083933 0.010729084668545556 0.005666924799524581 0.029560551636165028 1.0751528936441198e-07 6.968529771893101 -0.9998775633602892 down VFDSHPVLHVCLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFDSHPVLHVCLK 13 0 Q9BXW9;Q9BXW9-1 Q9BXW9 FANCD2 Fanconi anemia group D2 protein 0 3316110.0 1025500.0 753510.0 1537100.0 False True 1404655.0630954655 720217.4366756446 1174068.6375682002 1.0 0.5127361553721862 0.8358412455944041 20.421784464995703 -10.191793322468222 5.444546917850401 1.0000129572742242 0.6742887004832526 0.575358887160172 0.13190710072354775 2.0747420290193124e-05 3.0798008479731442e-06 0.1277235792112865 0.042572833695711285 6.429936404356999e-11 10.191793322468222 -0.3257242567909716 VFEELQATDK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFEELQATDKK 11 1 P57740-2;P57740;P57740-3;H0YG15 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 15768700.0 1318800.0 2259300.0 12190600.0 True False 2000716.017194568 1856110.2630085298 9781122.566670217 1.0 0.9277229986948341 4.888811046949804 20.932084974118908 -6.902745025810682 0.9437494013336749 0.8474854928280382 5.328574552279047 0.9878832413045396 0.2036930778531905 0.10941288499723596 0.16624264213350456 0.16100202437344932 0.4249750357233714 1.2509932725192303e-07 6.902745025810682 4.481089059451008 up VFEELQATDK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFEELQATDKK 11 1 P57740-2;P57740;P57740-3;H0YG15 P57740-2 NUP107 Nuclear pore complex protein Nup107 1 23331400.0 1318800.0 3031800.0 18980800.0 True False 1707212.597434454 2863077.664833609 15526489.15945452 1.0 1.677048112892415 9.094643035546508 20.703211296211357 -6.924750370407407 0.7886980227554442 0.8626166915827349 10.43203207622536 0.9954019327366248 0.2486356022866359 0.09545660511464023 0.09171746790866846 0.2198045360876072 0.6915449674626014 1.189185567018608e-07 6.924750370407407 9.569415384642625 up VFEGNRPTNSIVFTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFEGNRPTNSIVFTK 15 1 P06744;A0A2U3TZU2;P06744-2;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 67098000.0 14827000.0 24346000.0 27925000.0 False True 19438340.584872235 20713671.69996473 25035588.875514705 1.0 1.0656090528676616 1.2879488743498246 24.212401728208746 -6.948684217614361 0.5731150265358226 0.9972679201410859 1.3671578381287093 0.9990938768046754 0.0037092249632847507 0.08401859682466271 0.038183707660491804 0.003915878734064077 0.01853964777774539 1.1254229893877119e-07 6.948684217614361 0.3698899179876234 VFEGNRPTNSIVFTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFEGNRPTNSIVFTK 15 1 P06744;A0A2U3TZU2;P06744-2;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 44734100.0 9682700.0 7932400.0 27119000.0 False True 9375327.988542013 11099848.686919536 20015720.34743889 1.0 1.1839424391856086 2.1349354787268195 23.160437732264416 -6.939062746307094 0.6682343965137431 0.9891330213434045 2.384461530694166 0.9980384389370733 0.02202782406648805 0.08819697125406348 0.05657819827645672 0.021293034086317324 0.08219391781792429 1.1506341347975953e-07 6.939062746307094 1.3953285093507612 up VFEGNRPTNSIVFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFEGNRPTNSIVFTK 15 1 P06744;A0A2U3TZU2;P06744-2;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 121627200.0 7836400.0 110090000.0 3700800.0 False True 11888391.717579246 90443579.36290407 2969335.2578817364 1.0 7.607722012487699 0.24976761604271586 23.503050222187436 -6.670059472461841 1.9376708197729795 5.2175047885605625 0.27980092363128334 0.2791882818803092 2.8067807370304805 0.460920084456245 3.336562459919964 1.1662714302611261 3.1151658148596377 2.137669336155127e-07 6.670059472461841 -4.937703864929279 VFEGNRPTNSIVFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFEGNRPTNSIVFTK 15 1 P06744;A0A2U3TZU2;P06744-2;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 64036000.0 14827000.0 22115000.0 27094000.0 False True 20308942.584608927 21137886.17547462 20694955.218445633 1.0 1.040816679027588 1.0190070276789913 24.275611789731638 -10.245152189805257 3.868080666653899 0.9999640224909155 1.0299118533610034 0.7149373886981273 0.008903752903962257 2.7658075075359254e-06 5.397477005128969e-07 0.008631390732159959 0.002873673889553204 5.686536226482547e-11 10.245152189805257 0.0299478308700879 VFEGNRPTNSIVFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFEGNRPTNSIVFTK 15 1 P06744;A0A2U3TZU2;P06744-2;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 22827800.0 9682700.0 8789700.0 4355400.0 False True 8051594.066340708 8742348.14148115 5266094.0029057 1.0 1.0857909712597291 0.6540436539045537 22.940843007698692 -6.855060874752566 1.2103636280670307 1.046064833792984 0.6350175526289088 0.9473578507459173 0.04281843737943275 0.15197703682375824 0.42589782435443324 0.02764121166893175 0.06420822777123458 1.3961726468001851e-07 6.855060874752566 -0.4110472811640753 VFEGNRPTNSIVFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFEGNRPTNSIVFTK 15 1 P06744;A0A2U3TZU2;P06744-2;CON__Q3ZBD7 P06744 GPI Glucose-6-phosphate isomerase 0 18887000.0 7836400.0 6368100.0 4682500.0 False True 10144374.278537573 6013709.6369902 3830333.046507299 1.0 0.59281227918743 0.3775819918840263 23.274176544279886 -10.367021188352656 0.13209209964421545 1.8243306781372444 3.316703010690731e-11 0.9997964390932704 0.003682399421290073 2.1203986619615844 0.06751267340821177 0.7999202227489535 0.22864367590446424 4.295154710593518e-11 10.367021188352656 -1.8243306781040773 VFEK(ub)YGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFEKYGR 7 1 J3QL05;J3KP15;Q01130-2;Q01130;Q9BRL6-2;Q9BRL6 J3QL05 SRSF2;SRSF8 Serine/arginine-rich splicing factor 2;Serine/arginine-rich splicing factor 8 1 15986000.0 6422900.0 6868700.0 2694400.0 True False 8420484.099452086 5843916.733982891 2415609.334509826 1.0 0.6940119671223118 0.2868729761828073 23.005471746535378 -7.156641288897177 0.35355125094525214 1.0433114643377333 4.352591668737261e-12 0.9998652632555366 0.003390666412296612 0.08299021682511722 0.01847872236155165 0.007753736171268899 0.03875404946281018 6.972021394132551e-08 7.156641288897177 -1.0433114643333807 down VFEK(ub)YGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFEKYGR 7 1 J3QL05;J3KP15;Q01130-2;Q01130;Q9BRL6-2;Q9BRL6 J3QL05 SRSF2;SRSF8 Serine/arginine-rich splicing factor 2;Serine/arginine-rich splicing factor 8 1 17787700.0 6095600.0 6985000.0 4707100.0 True False 5902098.514562749 9774146.926293805 3474169.300026903 1.0 1.656046049075125 0.5886328890401931 22.49279657096244 -6.740426477182322 1.685373068933488 1.3901512597117938 0.5879760427175572 0.6067896546109346 0.27563843592939097 0.3170273141846582 1.7683656903270863 0.12938057972010614 0.31731058465828366 1.8179147894657285e-07 6.740426477182322 -0.8021752169942366 VFEK(ub)YGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFEKYGR 7 1 J3QL05;J3KP15;Q01130-2;Q01130;Q9BRL6-2;Q9BRL6 J3QL05 SRSF2;SRSF8 Serine/arginine-rich splicing factor 2;Serine/arginine-rich splicing factor 8 1 21972000.0 6161200.0 6835400.0 8975400.0 True False 9346990.844054589 5615569.464776037 7201408.255942431 1.0 0.6007890195322032 0.770452049872616 23.156070550035725 -10.190146678311027 5.381511582674262 1.0000137790456838 0.6856205347023497 0.8207232060157156 0.06926464209160196 1.145128359788235e-05 1.723451618004931e-06 0.0670681385078343 0.022355067108452267 6.454362030522254e-11 10.190146678311027 -0.31439324434333404 VFEK(ub)YGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFEKYGR 7 1 J3QL05;J3KP15;Q01130-2;Q01130;Q9BRL6-2;Q9BRL6 J3QL05 SRSF2;SRSF8 Serine/arginine-rich splicing factor 2;Serine/arginine-rich splicing factor 8 1 13388100.0 6422900.0 3931600.0 3033600.0 True False 8797619.70234605 3757888.911937414 2317126.158953156 1.0 0.42714836956811203 0.2633810322961847 23.06868180805827 -13.999999999999936 0.1756126570834132 3.9338001367443973 0.1272250868938284 0.999504091552986 0.007032624734626677 12.151123514200842 0.13279703840475787 12.153180373478264 0.1269912719225484 1.0000000000001472e-14 13.999999999999936 -3.806575049850569 VFEK(ub)YGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFEKYGR 7 1 J3QL05;J3KP15;Q01130-2;Q01130;Q9BRL6-2;Q9BRL6 J3QL05 SRSF2;SRSF8 Serine/arginine-rich splicing factor 2;Serine/arginine-rich splicing factor 8 1 21037900.0 6095600.0 11180000.0 3762300.0 True False 5068761.48086654 11119771.120943762 4548979.535090258 1.0 2.1937846479694207 0.897453855791332 22.273201846396717 -6.664663982394778 1.9566544246418016 1.7654809025966565 0.9028440968359055 0.25544599802470924 0.507730564001246 0.4735092635861712 3.4897125723255717 0.20930877192468045 0.5630660145001513 2.1643924862883342e-07 6.664663982394778 -0.862636805760751 VFEK(ub)YGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFEKYGR 7 1 J3QL05;J3KP15;Q01130-2;Q01130;Q9BRL6-2;Q9BRL6 J3QL05 SRSF2;SRSF8 Serine/arginine-rich splicing factor 2;Serine/arginine-rich splicing factor 8 1 19944300.0 6161200.0 8122000.0 5661100.0 True False 7975794.855408836 7670003.560188195 4630837.88779124 1.0 0.9616600851997507 0.5806114590134935 22.927196872128174 -6.92629691482673 0.7765906617818894 1.0066589544438738 0.5092843236099784 0.9957589303769707 0.01232872375815365 0.09460692457289448 0.08743921341988171 0.010993787713575964 0.03520648130041468 1.1849583487410613e-07 6.92629691482673 -0.4973746308338953 VFELMTSLHTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFELMTSLHTK 11 0 Q06323;Q06323-3;Q06323-2;H0YLU2 Q06323 PSME1 Proteasome activator complex subunit 1 0 42537500.0 15426000.0 15957500.0 11154000.0 False True 20223635.3855965 13576703.201847825 9999891.076723056 1.0 0.6713285194766371 0.49446555409345894 24.26953902254777 -12.644371253953704 0.08748064101621993 2.3921944373864883 2.393588131805241e-16 0.9998895763971515 0.0022010786810737334 7.4727252474562125 0.07169674138636552 2.2639386039835365 0.3930759745198026 2.267925301068683e-13 12.644371253953704 -2.392194437386488 VFELMTSLHTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFELMTSLHTK 11 0 Q06323;Q06323-3;Q06323-2;H0YLU2 Q06323 PSME1 Proteasome activator complex subunit 1 0 32692200.0 12743000.0 6569200.0 13380000.0 False True 12338480.440165553 9192315.81792545 9875376.608604014 1.0 0.7450119860790662 0.8003721897922391 23.55666139286198 -10.775047136961462 7.005857624038818 1.006034298904714 0.7726920879356968 0.9574083226602952 0.022600708525634065 0.0021662416207780906 6.955632257750465e-05 0.022253715892422376 0.007294347311022393 1.6786218158858446e-11 10.775047136961462 -0.2333422109690172 VFELMTSLHTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFELMTSLHTK 11 0 Q06323;Q06323-3;Q06323-2;H0YLU2 Q06323 PSME1 Proteasome activator complex subunit 1 0 128489100.0 21249000.0 65714000.0 41526100.0 False True 32236286.50998438 53986823.274174534 33318448.13346379 1.0 1.674722156891535 1.0335696738253097 24.94218222500684 -10.110172885752403 4.593553258827529 0.9999719814379171 1.3541459153654407 0.2891667185126212 0.2617494051683103 7.762158580603337e-05 1.5036824931257706e-05 0.25345847063557375 0.08447925725383108 7.759381664483735e-11 10.110172885752403 0.3541739339275236 VFELMTSLHTK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VFELMTSLHTK 11 0 Q06323;Q06323-3;Q06323-2;H0YLU2 Q06323 PSME1 Proteasome activator complex subunit 1 0 51832410.0 16490800.0 14654210.0 20687400.0 False True 22587894.40711329 14006738.547207855 15801462.190376949 1.0 0.6200993459043667 0.6995544562755178 24.429046456412365 -10.129134968310103 5.361219219935031 1.0000072912401243 0.6598269010897937 0.9606912833516369 0.032437412978174436 2.8269744230126253e-06 4.5919034418593204e-07 0.03140806280701955 0.010469130021466252 7.427882612444037e-11 10.129134968310103 -0.34018039015033064 VFELMTSLHTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFELMTSLHTK 11 0 Q06323;Q06323-3;Q06323-2;H0YLU2 Q06323 PSME1 Proteasome activator complex subunit 1 0 25746300.0 12743000.0 5988100.0 7015200.0 False True 10596369.110617882 5955840.916755209 8482045.88538001 1.0 0.5620643122734632 0.8004671974743446 23.337066668296256 -10.083369667309187 5.190358758099839 1.0000055691440553 0.681265754873331 0.7044279305289386 0.0973275703269119 6.272348925170897e-06 1.1076620105670081e-06 0.09423866011093936 0.03141233824995905 8.253351331328896e-11 10.083369667309187 -0.3187398142707243 VFELMTSLHTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFELMTSLHTK 11 0 Q06323;Q06323-3;Q06323-2;H0YLU2 Q06323 PSME1 Proteasome activator complex subunit 1 0 103002400.0 21249000.0 45135000.0 36618400.0 False True 27507249.38041002 42623197.57314636 29954226.93651312 1.0 1.549525980722069 1.0889575515989534 24.713308547099288 -10.346732965159983 3.9323796535595923 0.999139961005125 1.319241766184347 0.3904684811984521 0.18802627391013482 134079865.89399451 1355.0143539216062 1045822.7019638661 0.06436595979593607 4.500564962720262e-11 10.346732965159983 0.32010180517922193 VFEVNASNLEKQTSK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFEVNASNLEKQTSK 15 1 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 1 34819000.0 10908000.0 0.0 23911000.0 True False 16548233.481618416 0.0 19184980.36943642 1.0 0.0 1.159337061006957 23.980173882251147 -10.681877375945882 4.534175081485563 1.0151763789248913 0.5796685305058693 0.14913038092105402 0.4732973732276125 0.07338627316243275 0.005148854955939465 0.46316132731297366 0.15275607035950436 2.080283977193685e-11 10.681877375945882 -0.435507848419022 VFEVNASNLEKQTSK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFEVNASNLEKQTSK 15 1 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 1 11087400.0 2857100.0 8230300.0 0.0 True False 2375805.2409908418 8185961.740313354 0.0 1.0 3.4455525221837444 0.0 21.179985143942194 -6.716073498316091 1.7735844627489457 2.4940372806461784 0.006559536867197108 0.4939119220941376 1.0296199682229783 0.3629773620562269 2.2292377992411008 0.46135590249429786 1.1634973664426262 1.922766299852061e-07 6.716073498316091 -2.4874777437789812 VFEVNASNLEKQTSK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFEVNASNLEKQTSK 15 1 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 1 28629000.0 10908000.0 0.0 17721000.0 True False 14120621.028825477 0.0 14495959.832814902 1.0 0.0 1.0265808991844776 23.751300204343597 -12.103716409873734 18.348244444693 0.8900500951877084 0.5619614046330246 0.0 0.4911040982810883 0.0 0.0 0.0 0.14149199853537492 7.875598908712726e-13 12.103716409873734 -0.3280886905546838 VFFIQACQGDNYQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFFIQACQGDNYQK 14 0 Q14790;Q14790-9;Q14790-3;H7C0E2;Q14790-2;Q14790-4 Q14790;Q14790-2 CASP8 Caspase-8;Caspase-8 subunit p18;Caspase-8 subunit p10 0 11294200.0 2616800.0 5206900.0 3470500.0 False True 3430650.1411272488 4430050.816337234 3111405.951386709 1.0 1.2913152417464524 0.9069435306406262 21.710050576188376 -6.704053535176933 1.8165348317517676 1.1801755888910113 0.9080013444255415 0.43674360679692914 0.12287954426137775 0.38716843304707 2.48652982784013 0.053910705293019556 0.13794837984451175 1.976725955467224e-07 6.704053535176933 -0.2721742444654698 VFFIQACQGDNYQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFFIQACQGDNYQK 14 0 Q14790;Q14790-9;Q14790-3;H7C0E2;Q14790-2;Q14790-4 Q14790;Q14790-2 CASP8 Caspase-8;Caspase-8 subunit p18;Caspase-8 subunit p10 0 13176000.0 2616800.0 5385500.0 5173700.0 False True 3584301.67636101 5147550.802533055 3951778.615696181 1.0 1.4361377103054411 1.1025239984007862 21.773260637711267 -9.999985762143275 5.0845696944757135 0.9999977836243013 1.269330854355256 0.4649564641783728 0.13619722756782893 3.4220024690175204e-06 6.732480567819577e-07 0.13187348316506414 0.04395746617974994 1.0000327844140477e-10 9.999985762143275 0.2693330707309547 VFGALK(ub)GAVDGGLSIPHSTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFGALKGAVDGGLSIPHSTK 20 1 P46777;A0A2R8Y6J3;Q5T7N0 P46777 RPL5 60S ribosomal protein L5 1 9891000.0 2211100.0 1549800.0 6130100.0 True False 2140909.840794949 2168643.2221002323 4524442.91094196 1.0 1.0129540164545114 2.1133271587289135 21.029792610738014 -6.909469452934903 0.899325902929547 0.9653555376930527 2.2539365941292084 0.9907200855135747 0.050266293417235625 0.10477046070930421 0.14067285142870325 0.04104596472580554 0.11289529546099539 1.2317726221473184e-07 6.909469452934903 1.2885810564361557 up VFGALK(ub)GAVDGGLSIPHSTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFGALKGAVDGGLSIPHSTK 20 1 P46777;A0A2R8Y6J3;Q5T7N0 P46777 RPL5 60S ribosomal protein L5 1 7439200.0 2211100.0 2289500.0 2938600.0 True False 1838627.6183384743 2277166.00906983 3553047.6734487517 1.0 1.2385139798605076 1.9324455033801566 20.81019788617229 -6.95213821893946 0.5348570609963617 0.9894233851528702 2.213300703645796 0.9993585622341111 0.010017040953076683 0.08263838168625293 0.03249596203142836 0.011097120116959507 0.057422509397237136 1.1165078504696599e-07 6.95213821893946 1.223877318492926 VFGFSLITNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFGFSLITNK 10 0 P00491 P00491 PNP Purine nucleoside phosphorylase 0 35340000.0 11124000.0 14906000.0 9310000.0 False True 14583671.724969253 12682082.903132915 8346690.5078260405 1.0 0.8696083635384801 0.572331211592987 23.797850656339648 -6.957404969814183 0.4705813369825066 1.0078077141787873 0.42193298920370037 0.9996615188466227 0.0032926818968472566 0.08064146376522932 0.02465759179223951 0.004114843615838109 0.02453491617231707 1.1030495713348422e-07 6.957404969814183 -0.585874724975087 VFGFSLITNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFGFSLITNK 10 0 P00491 P00491 PNP Purine nucleoside phosphorylase 0 40886500.0 22896100.0 7926400.0 10064000.0 False True 22169275.83819151 11091452.855629934 7427936.486471658 1.0 0.5003074045622383 0.3350554407228487 24.40205830939587 -13.999999999999998 0.15464564749016824 3.4351419850565583 0.16260999758314645 0.99955148147701 0.005986584710932403 11.978246852828875 0.12406994238110398 8.75530059361304 0.15618041672023492 1.0000000000000041e-14 13.999999999999998 -3.272531987473412 VFGFSLITNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFGFSLITNK 10 0 P00491 P00491 PNP Purine nucleoside phosphorylase 0 82756000.0 23259000.0 24649000.0 34848000.0 False True 35285603.46066763 20250193.36648398 27960277.525579005 1.0 0.5738939221786751 0.7923990178245339 25.072576347640826 -10.077610120718143 4.84791702268758 1.0000106951997236 0.6831464699984273 0.7370986036157294 0.08920433176602235 1.0312093076314743e-05 1.961918160093564e-06 0.08637463741393976 0.02879057427672059 8.363535011298897e-11 10.077610120718143 -0.3168642252012963 VFGFSLITNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFGFSLITNK 10 0 P00491 P00491 PNP Purine nucleoside phosphorylase 0 47536000.0 11124000.0 13582000.0 22830000.0 False True 15236843.41479666 12981902.330332182 17438024.198609088 1.0 0.8520073336006931 1.1444643568151942 23.86106071786254 -6.769118817901168 1.5776599961956657 0.9150201021004832 1.14606118400649 0.7272351662816015 0.062357852817872546 0.26785883376428704 1.315603356816768 0.031156412901502766 0.07423033922670383 1.7016928813925918e-07 6.769118817901168 0.2310410819060068 VFGFSLITNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFGFSLITNK 10 0 P00491 P00491 PNP Purine nucleoside phosphorylase 0 40794200.0 22896100.0 8021600.0 9876500.0 False True 19039121.619211957 7978386.04863706 11941630.486223562 1.0 0.4190522130278451 0.6272154107242808 24.182463584830145 -10.100555666554643 5.153576566434827 1.000011041835951 0.5231338118752324 0.8749561354454626 0.08498226959997145 1.0781777030249287e-05 1.881772104030957e-06 0.08228563268472916 0.027427909573214858 7.933125658520335e-11 10.100555666554643 -0.47687722996071846 VFGFSLITNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFGFSLITNK 10 0 P00491 P00491 PNP Purine nucleoside phosphorylase 0 101552000.0 23259000.0 40528000.0 37765000.0 False True 30109234.003433403 38272581.17302474 30892157.501622662 1.0 1.271124372299224 1.0260027703826666 24.843702669733275 -10.658919615255385 2.7387593726958848 0.9827379759429256 1.148563571096124 0.3287594726755386 0.1000704794614561 27079885.916449826 24687038.634235714 3286273.2049233806 0.04126198177974816 2.193210845132952e-11 10.658919615255385 0.1658255951531984 VFGGTVHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFGGTVHK 8 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 3527970.0 382270.0 1862900.0 1282800.0 False True 501159.67190794606 1584962.5815273256 1150068.161486492 1.0 3.162590029427696 2.294813860636693 18.934910800750103 -10.485151038483947 6.117417869959577 0.9987748977195978 2.728701945032158 0.8410506945914225 0.354268137414208 0.005921795529616553 0.0004983839658943608 0.3431588343580977 0.11433954969142895 3.2722687246554996e-11 10.485151038483947 1.72992704731256 VFGNEIK(ub)LEKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFGNEIKLEKPK 12 2 P19338 P19338 NCL Nucleolin 1 8301600.0 3486700.0 2187300.0 2627600.0 True False 3376016.617023088 3060700.296618814 1939352.7336896763 1.0 0.906601075713213 0.5744499964575895 21.68689057444682 -6.947578059628427 0.584828522516493 1.0039026761367482 0.4605828225157863 0.9989972593855322 0.005782759565506225 0.0844730907833013 0.04010136414210543 0.006027630830906039 0.02778391873843816 1.128293121095341e-07 6.947578059628427 -0.5433198536209619 VFGNEIK(ub)LEKPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFGNEIKLEKPK 12 2 P19338 P19338 NCL Nucleolin 1 27666500.0 8040000.0 6550500.0 13076000.0 True False 12197267.802733047 5381512.095709894 10491522.868585596 1.0 0.4412063572551925 0.8601535227614463 23.540054683402175 -9.799715908407169 6.2172015322210665 1.0000000120452388 0.6506799400080713 0.48105147882462496 0.17103446411353163 2.8706535892488475e-08 5.556771135249274e-09 0.16560341518744218 0.055201135928132646 1.5859302816906246e-10 9.799715908407169 -0.34932007203716753 VFGNEIK(ub)LEKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFGNEIKLEKPK 12 2 P19338 P19338 NCL Nucleolin 1 7624000.0 3230500.0 2382100.0 2011400.0 True False 4424903.150979917 2276850.9454487055 1536348.7460833257 1.0 0.514553848471121 0.347205055944127 22.07721444821923 -13.999999999999998 0.14858315104575187 3.3423642452816273 0.1600548479749277 0.9995710378241986 0.005733913517580096 11.952698017912272 0.1213230228848539 8.086829930305381 0.16846089479014056 1.0000000000000041e-14 13.999999999999998 -3.1823093973066996 VFGNEIK(ub)LEKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFGNEIKLEKPK 12 2 P19338 P19338 NCL Nucleolin 1 11046900.0 3486700.0 5432400.0 2127800.0 True False 2899345.537000027 5403134.582953025 2572713.1421643794 1.0 1.8635704209797932 0.8873427155655216 21.467295849881097 -6.673260115039564 1.9262479369663579 1.549668768726444 0.8912628156654616 0.29343971087861653 0.36655361289313815 0.4536387214662353 3.2482029388635514 0.1530450701226079 0.4071035976941465 2.1219731530602023e-07 6.673260115039564 -0.6584059530609825 VFGNEIK(ub)LEKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFGNEIKLEKPK 12 2 P19338 P19338 NCL Nucleolin 1 25387000.0 8040000.0 6213000.0 11134000.0 True False 10407938.492093587 5867241.0883340575 9107726.244487392 1.0 0.5637274944304408 0.8750749489349976 23.311181005494625 -10.031218580446058 6.175513947257208 1.000000291986389 0.7194012216827103 0.5199181254618475 0.12710706604179345 5.109806704430127e-07 8.018017687411125e-08 0.12307101586214227 0.04102362916375789 9.306393667128145e-11 10.031218580446058 -0.2805990703036788 VFGVHYFNIFNTVTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFGVHYFNIFNTVTLK 16 0 A0A3B3IT82;P54132 A0A3B3IT82 BLM Bloom syndrome protein 0 82047000.0 16311000.0 27418000.0 38318000.0 False True 24744979.49382822 22525043.682188235 30744430.50462398 1.0 0.9102874256899801 1.242451241969795 24.560632510855143 -6.834795357768592 1.3064100648639931 0.9521994679372399 1.2522933952945128 0.9151165915781415 0.04087686496911057 0.17496859227203904 0.5823140744843118 0.024554439655084838 0.05651198081663877 1.4628663236887396e-07 6.834795357768592 0.3000939273572729 VFGVHYFNIFNTVTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFGVHYFNIFNTVTLK 16 0 A0A3B3IT82;P54132 A0A3B3IT82 BLM Bloom syndrome protein 0 46212000.0 16311000.0 14530000.0 15371000.0 False True 21114911.037877936 13721392.727103498 12573635.719778677 1.0 0.6498437385072927 0.5954860855071988 24.331758832947592 -13.999999999999998 0.26222831501919924 3.5933670109602467 0.5760387007688758 0.9995669132557636 0.0037304529190311264 14.516809000289507 0.16205608753342526 19.97648535097885 0.023488733415118677 1.0000000000000041e-14 13.999999999999998 -3.017328310191371 VFHAGFGVVLGEDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFHAGFGVVLGEDK 14 0 P54136;P54136-2 P54136 RARS Arginine--tRNA ligase, cytoplasmic 0 5222810.0 1576200.0 919410.0 2727200.0 False True 2158963.735203385 878787.4261177088 2083091.5284470723 1.0 0.4070413095822208 0.9648571184781086 21.041907579483276 -10.730418003721406 9.982704380316445 1.0006395028871788 0.6859492140301654 0.2970748811147771 0.2277273503754631 0.0032471153485713255 8.768768140895993e-05 0.22089734173478823 0.0734986862900092 1.8602957602487946e-11 10.730418003721406 -0.31469028885701344 VFHFLVFQLNTTDLDCNEGVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFHFLVFQLNTTDLDCNEGVK 21 0 Q9BZE1;A6NHR2;S4R369;H0Y4J2 Q9BZE1 MRPL37 39S ribosomal protein L37, mitochondrial 0 117512000.0 25549000.0 37229000.0 54734000.0 False True 38759700.88209283 30585194.07849539 43915800.90923561 1.0 0.7890977841014737 1.133027343085739 25.20805410138387 -6.74076253881175 1.6838004744434043 0.8746264288503998 1.133267101383455 0.608415187721883 0.08861075252676248 0.3164334825024646 1.7618262016302744 0.04162616313226088 0.10206559217408617 1.8165086120443123e-07 6.74076253881175 0.2586406725330552 VFHFLVFQLNTTDLDCNEGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFHFLVFQLNTTDLDCNEGVK 21 0 Q9BZE1;A6NHR2;S4R369;H0Y4J2 Q9BZE1 MRPL37 39S ribosomal protein L37, mitochondrial 0 71873000.0 25549000.0 19182000.0 27142000.0 False True 33073684.146081947 18114504.837666836 22202434.500438027 1.0 0.5477014522379043 0.6713021265599837 24.97918042347632 -10.319984051627245 8.482345466938545 1.0000006660224228 0.6095017893989512 0.9301123759506533 0.05045976399216957 6.35585698685132e-07 5.089688360805739e-08 0.048857540114357056 0.016285818799602447 4.7864766913192864e-11 10.319984051627245 -0.3904988766234716 VFHLLGVDTLVVTNAAGGLNPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFHLLGVDTLVVTNAAGGLNPK 22 0 P00491;G3V5M2;G3V393 P00491 PNP Purine nucleoside phosphorylase 0 24705700.0 14650000.0 5677600.0 4378100.0 False True 14184943.769004578 7944695.288292855 3231344.269815335 1.0 0.5600794347632702 0.22780099254789596 23.757857095800965 -8.001988276945461 0.2866787121960172 1.1372112427826375 4.589610322612519e-25 0.9993230816288189 0.008228555824766705 0.09947816436278198 0.05452217234640455 0.061071652193805594 0.09158375509170061 9.954322870217133e-09 8.001988276945461 -1.1372112427826375 down VFHLLGVDTLVVTNAAGGLNPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFHLLGVDTLVVTNAAGGLNPK 22 0 P00491;G3V5M2;G3V393 P00491 PNP Purine nucleoside phosphorylase 0 35776000.0 10771000.0 13047000.0 11958000.0 False True 16340394.465576805 10718660.91332373 9594496.058622418 1.0 0.6559609644616599 0.5871642865681418 23.961939475520243 -13.999999999999998 0.22628173438676855 3.1351090186284423 0.5525089740052943 0.999504946926625 0.004018183896992139 13.178153862983931 0.15064545388623568 12.615494036848432 0.036556219221512504 1.0000000000000041e-14 13.999999999999998 -2.582600044623148 VFHLLGVDTLVVTNAAGGLNPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFHLLGVDTLVVTNAAGGLNPK 22 0 P00491;G3V5M2;G3V393 P00491 PNP Purine nucleoside phosphorylase 0 22940000.0 14650000.0 4407600.0 3882400.0 False True 12182124.105042137 4383855.383959895 4694191.889810596 1.0 0.3598596883564364 0.38533443341524376 23.53826237123524 -10.42453457472121 5.979441695732056 1.0002272922304678 0.3725970608858513 0.9987650444489176 0.010400021120261666 3.1523492179598234e-05 3.0338391241945666e-06 0.010073325750820645 0.0033565923832481162 3.7624039811168826e-11 10.42453457472121 -0.6276302313446165 VFHLLGVDTLVVTNAAGGLNPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFHLLGVDTLVVTNAAGGLNPK 22 0 P00491;G3V5M2;G3V393 P00491 PNP Purine nucleoside phosphorylase 0 32227700.0 10771000.0 13684000.0 7772700.0 False True 13943271.82815173 12922473.370797252 6358148.354636899 1.0 0.9267891733062632 0.45600117626622444 23.733065797612692 -6.934386199820677 0.7098631375685008 1.0061278003677772 0.34758761906677316 0.9973323003764115 0.012450058279395968 0.09042337170468075 0.06698544797018209 0.011654651401928994 0.04161878417881104 1.1630912812312366e-07 6.934386199820677 -0.658540181301004 down VFHLTCHVPTLLSFPSGDWICTFCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFHLTCHVPTLLSFPSGDWICTFCR 25 0 H0Y612;Q9UPN9-2;Q9UPN9 H0Y612 TRIM33 E3 ubiquitin-protein ligase TRIM33 0 55552000.0 18869000.0 15578000.0 21105000.0 False True 28625652.50867784 12797984.188530464 16933587.499349892 1.0 0.4470809594523921 0.5915528910377323 24.77080524337062 -10.362903332433678 8.817827740991108 1.000001158911205 0.5193169252451649 0.9365486444329734 0.05898041908972732 1.3437662353873354e-06 9.708498631495602e-08 0.05710768304705397 0.01903584840723733 4.3360738227500413e-11 10.362903332433678 -0.4806842336660401 VFHLTCHVPTLLSFPSGDWICTFCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFHLTCHVPTLLSFPSGDWICTFCR 25 0 H0Y612;Q9UPN9-2;Q9UPN9 H0Y612 TRIM33 E3 ubiquitin-protein ligase TRIM33 0 48420000.0 18869000.0 11990000.0 17561000.0 False True 24426292.46359625 11322745.959942924 14365078.191076275 1.0 0.46354746537231506 0.5880990007994575 24.54193156546307 -9.951989183962828 7.026345860355236 1.000000020523613 0.5258232330859968 0.9507996802631138 0.05084795141278391 1.636523815854672e-08 2.4014722071070575e-09 0.04923331945351264 0.01641110575087244 1.1168910634340728e-10 9.951989183962828 -0.47417678743761627 VFHMLDKDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFHMLDKDK 9 1 B8ZZ19;P20472;H0Y3U0;B1AH72 B8ZZ19 PVALB Parvalbumin alpha 0 4030060.0 427860.0 2300500.0 1301700.0 False True 560928.6034021338 1957274.3672787647 1167012.5707880931 1.0 3.489346692979357 2.0805010899960354 19.09745762660298 -9.938433588984385 6.125854925019493 0.9999994395127229 2.784923891487969 0.681547436890346 0.5751588089464439 4.402012489252225e-06 7.640226064711465e-07 0.5568953046467561 0.18563170737269652 1.1523022529744018e-10 9.938433588984385 1.7849244519752459 VFHMLDKDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFHMLDKDK 9 1 B8ZZ19;P20472;H0Y3U0;B1AH72 B8ZZ19 PVALB Parvalbumin alpha 0 5839060.0 427860.0 2821300.0 2589900.0 False True 586051.4044817413 2696645.637208529 1978218.9606648094 1.0 4.6013807263088715 3.3755041717103196 19.160667688125873 -9.650328823600345 7.990017361285407 1.0000000002116678 3.9884424490095967 0.8879404695290158 0.5004620077346686 0.0 6.918757896416215e-18 0.4845702553414393 0.16152341844714635 2.2370267451044976e-10 9.650328823600345 2.9884424487979286 VFIDK(ub)QTNLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFIDKQTNLSK 11 1 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4;Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3 G5EA30;Q5VZZ6 CELF1;CELF2 CUGBP Elav-like family member 1;CUGBP Elav-like family member 2 1 6126900.0 2476000.0 2283000.0 1367900.0 True False 3246059.97761811 1942385.2990643021 1226362.8298233338 1.0 0.5983824428560262 0.3778004221361347 21.630258226207225 -9.846675570305225 0.13894942050828626 1.6909115808855333 4.740266420359886e-10 0.9998061197720538 0.0035864367094405446 1.3631669901421533 0.0613809349493543 0.5557537206408548 0.2074241686500604 1.4233917020633255e-10 9.846675570305225 -1.6909115804115067 VFIDK(ub)QTNLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFIDKQTNLSK 11 1 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4;Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3 G5EA30;Q5VZZ6 CELF1;CELF2 CUGBP Elav-like family member 1;CUGBP Elav-like family member 2 1 16525300.0 3644500.0 3870000.0 9010800.0 True False 5528972.94863937 3179368.263551988 7229811.430426061 1.0 0.5750377679699811 1.307622861892506 22.39858008242121 -6.749429093806741 1.6518089220700574 0.7499442202101372 1.3090271756038934 0.6465363632636283 0.17856810754716043 0.3010600680188068 1.6159705360363619 0.08540155088059423 0.2074683866533568 1.7806186023479684e-07 6.749429093806741 0.5590829553937562 VFIDK(ub)QTNLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFIDKQTNLSK 11 1 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4;Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3 G5EA30;Q5VZZ6 CELF1;CELF2 CUGBP Elav-like family member 1;CUGBP Elav-like family member 2 1 5264200.0 2476000.0 1174800.0 1613400.0 True False 3391444.1113840803 1122893.4514559149 1232348.1490160266 1.0 0.33109596224413423 0.36336973529340977 21.693468287730116 -9.98388242709818 5.31594155213773 1.0000021625583524 0.3472328487837286 0.9981700098044678 0.01317571268406278 36263970.411599375 10.363302209633034 1149.2357075263794 0.004510396903639333 1.0378093352060327e-10 9.98388242709818 -0.6527693137746238 VFIDK(ub)QTNLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFIDKQTNLSK 11 1 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4;Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3 G5EA30;Q5VZZ6 CELF1;CELF2 CUGBP Elav-like family member 1;CUGBP Elav-like family member 2 1 6827200.0 2869900.0 2636500.0 1320800.0 True False 2386449.0081269885 2622296.651195724 1596973.1733107965 1.0 1.0988278577357247 0.6691838660169762 21.186434079605654 -6.8461821713616535 1.2533496811567288 1.0526135964857222 0.6532304101647295 0.934566670296967 0.04699723354954427 0.16170704992590057 0.4907487903112024 0.029368058058255382 0.06781504369893783 1.4250097264259203e-07 6.8461821713616535 -0.3993831863209927 VFIDK(ub)QTNLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFIDKQTNLSK 11 1 G5EA30;Q92879-2;Q92879-3;Q92879;Q92879-5;Q92879-6;Q92879-4;Q5VZZ6;A0A0J9YX66;A0A1B0GU44;E9PC62;A0A1B0GUN8;A0A0J9YXJ0;O95319-5;O95319-2;O95319;O95319-4;O95319-3 G5EA30;Q5VZZ6 CELF1;CELF2 CUGBP Elav-like family member 1;CUGBP Elav-like family member 2 1 16602200.0 3644500.0 3288100.0 9669600.0 True False 4717877.093835202 3105114.3445278034 7909832.018474523 1.0 0.6581592277139271 1.6765659344560317 22.169706404513658 -6.816198408530937 1.3883682061494853 0.8150105851113946 1.6970130280752946 0.875374635759003 0.14939313560884193 0.19847751027370242 0.7527667927327291 0.08458092545991096 0.1951586379778343 1.52686834521437e-07 6.816198408530937 0.8820024429639001 VFIGNLNTALVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFIGNLNTALVK 12 0 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 0 47857000.0 12013000.0 14893000.0 20951000.0 False True 15749159.334057491 12671022.4524593 18783191.496182963 1.0 0.8045523055353353 1.1926472453399077 23.90877148603329 -6.769767151699837 1.5751645985730178 0.8878645819064304 1.1948205015547615 0.7297438443964568 0.0823671274790438 0.2668010527874777 1.3063592107435378 0.04121661314052065 0.09814083135966731 1.6991544150652492e-07 6.769767151699837 0.30695591964833113 VFIGNLNTALVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFIGNLNTALVK 12 0 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 0 29052100.0 10428000.0 4638100.0 13986000.0 False True 10096968.84799861 6490117.517371977 10322647.028993698 1.0 0.6427787997640924 1.0223510822299726 23.267418919139548 -11.038781807537834 12.961478452719003 1.5327408045872393 0.8325649409970324 0.20599843112240568 0.15495973542416214 0.04055068089252454 0.0001213311232552108 0.0025504248062222456 0.05001303955254062 9.145726134833125e-12 11.038781807537834 -0.7001758635902069 VFIGNLNTALVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFIGNLNTALVK 12 0 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 0 26988200.0 3443600.0 17064000.0 6480600.0 False True 5224192.960882022 14018795.87835948 5199706.56945212 1.0 2.6834376110013802 0.9953128853368831 22.316776754601765 -6.646825074772537 2.0199720099834964 2.0951241871993083 1.0024118355894713 0.18124060334072534 0.7190752630577181 0.516353592444527 4.034703773067796 0.28907674017790735 0.7963208570673656 2.2551473580001276e-07 6.646825074772537 -1.092712351609837 VFIGNLNTALVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFIGNLNTALVK 12 0 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 0 35405600.0 12013000.0 9523600.0 13869000.0 False True 16454530.739118317 9102815.861666292 10593427.841020983 1.0 0.5532102984879196 0.6438000578063651 23.971981547556183 -9.926713508979754 5.623528989514228 1.0000003698471296 0.5985051781464801 0.9632221734538998 0.036983114377685214 1.714727965740619e-07 3.273559120504256e-08 0.03580877959973603 0.011936248839289699 1.1838222301574529e-10 9.926713508979754 -0.4014951917006495 VFIGNLNTALVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFIGNLNTALVK 12 0 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 0 19489200.0 10428000.0 4698300.0 4362900.0 False True 8671344.038728964 4672989.3253604695 5275162.2182296235 1.0 0.5389002332844162 0.608344242215403 23.047824194573824 -10.622658124095663 6.538999014090957 1.0014533037408282 0.5736222377499476 0.9804931862233559 0.028350397929032593 0.0006024182234070042 3.476335231208678e-05 0.027530510003235704 0.009150051586458045 2.3841955656733908e-11 10.622658124095663 -0.4278310659908806 VFIGNLNTALVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFIGNLNTALVK 12 0 Q5QPL9;Q9UKM9-2;Q9UKM9;Q5QPM1;Q5QPM2;Q5QPM0 Q5QPL9 RALY RNA-binding protein Raly 0 17129100.0 3443600.0 7450500.0 6235000.0 False True 4457808.083504157 7035873.125484133 5100293.97650251 1.0 1.5783257138233353 1.1441259652643712 22.087903076694214 -10.378214716188765 5.6285334864046925 0.9998857017666863 1.361225839543855 0.47993064563787025 0.17726130506904236 0.00025432382268320496 2.8095095554932617e-05 0.17168644597102975 0.05721084020494856 4.1858656379317555e-11 10.378214716188765 0.36134013777716867 VFIGNLNTLVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFIGNLNTLVVK 12 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 348310000.0 101660000.0 123120000.0 123530000.0 False True 133277244.4768403 104750975.91800116 110748300.58343178 1.0 0.7859629476073376 0.8309618121094678 26.989855237328765 -10.625086642269176 6.528640570900633 1.0006832498250264 0.808462379858403 0.9602496989727962 0.018370709505809664 0.00018332886046746306 1.0527840530022373e-05 0.017848937051825137 0.005929120997834584 2.370900660955888e-11 10.625086642269176 -0.19222086996662346 VFIGNLNTLVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFIGNLNTLVVK 12 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 281897000.0 103980000.0 74397000.0 103520000.0 False True 100679211.81577437 104104110.07522973 76405006.4665685 1.0 1.0340179288026443 0.7588955563773832 26.58519058637268 -6.875935046863944 1.1021783497325182 1.0201387442646999 0.7408530647673831 0.9702578714496588 0.02112033972613243 0.13129370729725026 0.29454066026019615 0.014810815553662862 0.03547557673182422 1.3306534157849552e-07 6.875935046863944 -0.27928567949731675 VFIGNLNTLVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFIGNLNTLVVK 12 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 395998000.0 52463000.0 256890000.0 86645000.0 False True 79590206.55905268 211045972.40926877 69519577.77214739 1.0 2.6516575535292937 0.8734689954670077 26.246087584705034 -6.662687752998634 1.9629321959899355 2.060738392915585 0.8807565197715507 0.24735534667443337 0.7027779912318666 0.47803962782786613 3.543486261097578 0.2889444516503637 0.7795262721793896 2.1742638590222675e-07 6.662687752998634 -1.1799818731440346 VFIGNLNTLVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFIGNLNTLVVK 12 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 355020000.0 101660000.0 107150000.0 146210000.0 False True 139246449.25820076 102415758.70233345 111678209.28947139 1.0 0.7354999660524686 0.8020183630132617 27.053065298851656 -9.305848521950056 10.828955554336297 0.9999983478870795 0.7687591636641662 0.9415658828709081 0.027156021860392916 0.0 0.0 0.02629370509606699 0.008764568365355661 4.944831282261882e-10 9.305848521950056 -0.23123918422291334 VFIGNLNTLVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFIGNLNTLVVK 12 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 184103000.0 103980000.0 32769000.0 47354000.0 False True 86463977.09503618 32592466.89286278 57255502.459842205 1.0 0.3769485048905284 0.6621890917290363 26.365595861806955 -10.457382292398362 6.169089485502738 1.0002158609133764 0.5195687983098299 0.7909041735726522 0.11644898194773004 0.0003458784696200422 3.042270810018473e-05 0.11280083361333874 0.03758374731386386 3.4883311618056234e-11 10.457382292398362 -0.4806470626035465 VFIGNLNTLVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFIGNLNTLVVK 12 0 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 0 265598000.0 52463000.0 131270000.0 81865000.0 False True 67914387.70033652 123964709.10439608 66966410.00583446 1.0 1.8253084994504314 0.9860415778364242 26.017213906797483 -10.40011500337949 3.7009806911856535 0.9975938854585187 1.4056750385486516 0.23752974081955625 0.34262928688240274 82509293.45275155 89300196.0320036 1804158.4633172269 0.12538948366867445 3.980017637141716e-11 10.40011500337949 0.40808115309013293 VFIGNLNTLVVK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFIGNLNTLVVKK 13 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 26219500.0 7358500.0 13068000.0 5793000.0 True False 9647064.759815356 11118305.338665044 5193595.930379835 1.0 1.15250655152416 0.5383602224806916 23.201658620449297 -6.8409956379280645 1.2779304618841854 1.0811181382417203 0.5177801536296083 0.9261251215712072 0.07096601704362143 0.16764097199415376 0.5314070890751766 0.04353910448930499 0.10032452173224896 1.4421298362645015e-07 6.8409956379280645 -0.563337984612112 VFIGNLNTLVVK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFIGNLNTLVVKK 13 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 60280000.0 20870000.0 23120000.0 16290000.0 True False 20207493.27366041 32351936.569207244 12023160.310475277 1.0 1.6009871254727368 0.5949852437237697 24.268387031651187 -6.744898758027589 1.6687701358283766 1.3555391312672191 0.5937425528188631 0.6267347225530895 0.2525000825617713 0.30901778426533866 1.6914484930860552 0.1196141950327357 0.2919580454860076 1.7992903136629445e-07 6.744898758027589 -0.761796578448356 VFIGNLNTLVVK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFIGNLNTLVVKK 13 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 68008000.0 16394000.0 15296000.0 36318000.0 True False 24870896.561940983 12566309.29180653 29139731.381255124 1.0 0.505261612122029 1.1716397641187806 24.567955179894703 -6.707868261274999 1.802629510846553 0.6951872743495653 1.1699894903643053 0.4550340649374306 0.20855094455366666 0.3793849828919767 2.4017485675505448 0.0921101398911579 0.23462522311266854 1.9594389588440125e-07 6.707868261274999 0.47480221601474004 VFIGNLNTLVVK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFIGNLNTLVVKK 13 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 31146500.0 7358500.0 10505000.0 13283000.0 True False 10079136.305985345 10040854.364610493 10145828.971972164 1.0 0.9962018629163574 1.0066169028736336 23.26486868197219 VFIGNLNTLVVK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFIGNLNTLVVKK 13 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 49043000.0 20870000.0 17673000.0 10500000.0 True False 17354329.697763067 17577792.041184165 12695501.45348529 1.0 1.012876460647737 0.7315466327185032 24.048792307085463 -6.896176505105018 0.9851469970008906 1.0129550700341874 0.7042082510444196 0.9845654021832497 0.016112387175786322 0.1142738639177413 0.19372735273931094 0.012349657328290596 0.03155680551591623 1.2700578259115122e-07 6.896176505105018 -0.30874681898976775 VFIGNLNTLVVK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFIGNLNTLVVKK 13 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;P07910-3;G3V3K6;G3V5X6;G3V251;B4DSU6;P0DMR1;B7ZW38;B2RXH8;A0A0G2JNQ3;O60812;A0A0G2JPF8;G3V4M8;G3V2H6;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;HNRNPCL4;HNRNPCL3;HNRNPCL2;HNRNPCL1 Heterogeneous nuclear ribonucleoproteins C1/C2;Heterogeneous nuclear ribonucleoprotein C-like 4;Heterogeneous nuclear ribonucleoprotein C-like 3;Heterogeneous nuclear ribonucleoprotein C-like 2;Heterogeneous nuclear ribonucleoprotein C-like 1 1 51718000.0 16394000.0 20012000.0 15312000.0 True False 21222356.174052514 18898314.60803818 12525373.114387557 1.0 0.8904908791957878 0.5901971021342902 24.339081501987152 -6.953451548094641 0.5195728247973529 1.0051196723359779 0.46217702683810774 0.9994450452699495 0.0040810791854420415 0.08212868475209058 0.030450372723245217 0.004626490439623891 0.024803383179994015 1.1131365725500575e-07 6.953451548094641 -0.5429426454978701 VFIPHGLIMDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFIPHGLIMDR 11 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 16282700.0 3260400.0 4512800.0 8509500.0 False True 4274415.973758518 3839507.830756626 7629018.568887838 1.0 0.8982532009818701 1.7848095776648523 22.02729588304873 -6.878344164917329 1.089037302469444 0.9382252826325423 1.8456668342487026 0.9723230821446143 0.06590146087431906 0.129104825572683 0.2812603346615406 0.04668364804223498 0.11242904396180617 1.323292451309922e-07 6.878344164917329 0.9074415516161602 VFIPHGLIMDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFIPHGLIMDR 11 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 13316500.0 4840700.0 1920400.0 6555400.0 False True 4687034.628165217 2687225.7347537023 4838344.082215444 1.0 0.573331743402468 1.0322825551876622 22.16024402292022 -11.879465873659646 17.691461684667694 0.8999573434842741 0.8225264363085666 0.0 0.21415920105466973 0.0 0.0 0.0 0.06224516386744711 1.3198790221454497e-12 11.879465873659646 -0.07743090717570755 VFIPHGLIMDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFIPHGLIMDR 11 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 12634700.0 3260400.0 3765100.0 5609200.0 False True 4465857.988997037 3598745.4324792917 4284422.485100216 1.0 0.8058351701612247 0.9593727556174333 22.09050594457162 -10.664433771937825 5.189728680295878 1.0021289024361673 0.8826039628893289 0.43804443641783053 0.06268145678444714 0.0015709841544763613 0.00010157926452402023 0.06175260929360104 0.020230353186848533 2.1655400897867794e-11 10.664433771937825 -0.1195249395468384 VFIPHGLIMDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFIPHGLIMDR 11 0 P00492 P00492 HPRT1 Hypoxanthine-guanine phosphoribosyltransferase 0 9047400.0 4840700.0 2670000.0 1536700.0 False True 4025256.5293704737 2655616.180046492 1858016.865101984 1.0 0.659738369634249 0.4615896779608645 21.940649298354497 -9.86351667568468 0.11380163031499868 1.7420684919796434 5.351236258368781e-14 0.9998995675206923 0.0022282224394740806 1.405102599911884 0.05079718624576342 0.5496263026046304 0.24168945160900404 1.3692518119694774e-10 9.86351667568468 -1.74206849197959 VFITDDFHDMMPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFITDDFHDMMPK 13 0 P14625 P14625 HSP90B1 Endoplasmin 0 16885800.0 1468000.0 7733600.0 7684200.0 False True 1924562.2161322206 6579777.025336698 6889112.696051213 1.0 3.4188435012301293 3.5795739094869146 20.87609887983617 -10.282544534976912 0.5693673249458124 1.652842865646711e-19 3.564541153230663 0.9996678704790721 0.021504163646392432 1.6013054188469078 0.2719897890734833 2.559596975080108 0.029076731044196964 5.2174159920395036e-11 10.282544534976912 3.564541153230663 VFITDDFHDMMPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFITDDFHDMMPK 13 0 P14625 P14625 HSP90B1 Endoplasmin 0 13122400.0 5114600.0 2673900.0 5333900.0 False True 4952239.822590499 3741602.2142042937 3936791.576429962 1.0 0.755537362535701 0.7949517223442221 22.239649751098526 -10.056698782633392 4.940894573943209 1.0000049086083256 0.7752445424381799 0.9774551870338861 0.016090845017876238 8.700640360477092e-07 1.6613028920037246e-07 0.015580233876560023 0.005193297897484087 8.776093011512076e-11 10.056698782633392 -0.22476036617014572 VFITDDFHDMMPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFITDDFHDMMPK 13 0 P14625 P14625 HSP90B1 Endoplasmin 0 18149500.0 1468000.0 8828700.0 7852800.0 False True 2010759.271208329 8438618.841393303 5998130.37349266 1.0 4.196732528962689 2.98301763884853 20.939308941359062 -9.22529997390263 10.552044260535657 1.0000048078598838 3.589875083905643 0.8585780643808011 0.4954970290075403 0.0 3.0919872555450195e-17 0.47976294250578544 0.1599209784522649 5.952508525504129e-10 9.22529997390263 2.589870276045759 VFITDDFHDMMPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFITDDFHDMMPK 13 0 P14625 P14625 HSP90B1 Endoplasmin 0 5114600.0 5114600.0 0.0 0.0 False True 4253016.515197851 0.0 0.0 1.0 0.0 0.0 22.020055026532802 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 VFLAQK(ub)MMIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFLAQKMMIGR 11 1 P14618;P14618-3;P14618-2;B4DNK4;H3BTN5;H3BR70;P30613-2;P30613 P14618 PKM;PKLR Pyruvate kinase PKM;Pyruvate kinase;Pyruvate kinase PKLR 1 9863400.0 1261300.0 1090900.0 7511200.0 True False 1632777.7139400044 1030190.4560218304 6144238.671420307 1.0 0.6309434819121278 3.7630588774964586 20.638896965352483 -6.877517961566538 1.0936003474680263 0.7779997608492989 3.9746849762983936 0.9716252621787415 0.23543148018660298 0.1298489199801875 0.28579447984703205 0.16619510405558152 0.3994703518581129 1.325812283635349e-07 6.877517961566538 3.1966852154490946 up VFLDFFTYAPPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFLDFFTYAPPK 12 0 Q15397 Q15397 KIAA0020 Pumilio domain-containing protein KIAA0020 0 3124300.0 980800.0 1075200.0 1068300.0 False True 1285838.2980807114 914784.3510967729 957762.5638572038 1.0 0.711430319397247 0.7448545943038053 20.29427779579638 -9.940305773018824 6.857098181194523 1.0000000147202694 0.7281424570090027 0.9887899742762251 0.013645403090602106 3.069899258537777e-09 4.593796853229324e-10 0.013212105518046968 0.004404034910181618 1.1473455273295628e-10 9.940305773018824 -0.27185755771126674 VFLDFFTYAPPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFLDFFTYAPPK 12 0 Q15397 Q15397 KIAA0020 Pumilio domain-containing protein KIAA0020 0 3282100.0 1627500.0 1654600.0 0.0 False True 1575835.903348458 2315290.408625011 0.0 1.0 1.469245880047093 0.0 20.587685879656988 -6.843414465050959 1.4213125075454298 1.2510855940470722 9.037615584288196e-22 0.8854017197410006 0.20742154644340288 0.18098091556463888 0.7342823648026324 0.11713963486746579 0.24952087635003053 1.434120140353757e-07 6.843414465050959 -1.2510855940470722 down VFLDFFTYAPPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFLDFFTYAPPK 12 0 Q15397 Q15397 KIAA0020 Pumilio domain-containing protein KIAA0020 0 5897800.0 980800.0 1644600.0 3272400.0 False True 1343428.2651233866 1571936.1340350711 2499526.5171935307 1.0 1.170093093054505 1.8605582315658384 20.35748785731927 -6.944537230844692 0.6159162202218949 0.9924172072873888 2.0745577634248176 0.9986997386188593 0.013418188118921086 0.08575649840292053 0.045633712993713604 0.013563967240573264 0.05834548346215978 1.1362208884703602e-07 6.944537230844692 1.0821405561374289 VFLDFFTYAPPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFLDFFTYAPPK 12 0 Q15397 Q15397 KIAA0020 Pumilio domain-containing protein KIAA0020 0 4077100.0 1627500.0 1143700.0 1305900.0 False True 1353338.3604748151 1137538.6610933254 1578957.6522006122 1.0 0.8405426863790538 1.1667131430802267 20.368091155091264 -6.773787625670854 1.5601843886315316 0.9089835002933915 1.1688067040406842 0.7447781556025264 0.06727655322324738 0.260336743311941 1.2511612122492368 0.03398038087379522 0.08060208390753451 1.6834971066755612e-07 6.773787625670854 0.25982320374729273 VFLENVIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFLENVIR 8 0 P62805 P62805 HIST1H4A Histone H4 0 114824000.0 25340000.0 33023000.0 56461000.0 False True 33220985.392909095 28096097.122645814 50618957.33215528 1.0 0.8457334058682928 1.5237042710647506 24.985591531021132 -6.846909099553701 1.2500671184930496 0.9178495744378155 1.5492094420846632 0.935656704400389 0.07360063674803825 0.16089826205668314 0.4854207914916879 0.046107680599476064 0.10649676312510328 1.4226265202474293e-07 6.846909099553701 0.6313598676468477 VFLENVIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFLENVIR 8 0 P62805 P62805 HIST1H4A Histone H4 0 130004100.0 60014000.0 9371100.0 60619000.0 False True 58108888.42000279 13113029.099640898 44741065.368981086 1.0 0.22566305183574994 0.7699521809055961 25.792255521450215 -10.050266484957096 6.6696064454393635 1.0000002325526778 0.49780761637692983 0.5316295693083856 0.22220510646083394 7.684567136524772e-07 1.0911534649954536e-07 0.21514926857363276 0.07171638973042067 8.907042304831271e-11 10.050266484957096 -0.502192616175748 VFLENVIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFLENVIR 8 0 P62805 P62805 HIST1H4A Histone H4 0 747196000.0 35794000.0 665560000.0 45842000.0 False True 54302114.89191874 546785617.955985 36781308.60673762 1.0 10.069324538174806 0.6773457844127435 25.69450505164571 -6.654123983256278 1.993700573688486 6.865838628063333 0.7167152911217933 0.21096055398086977 3.867001659855839 0.49851721179770997 3.802672042797203 1.57046387517692 4.284624553955217 2.217563255037902e-07 6.654123983256278 -6.14912333694154 VFLENVIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFLENVIR 8 0 P62805 P62805 HIST1H4A Histone H4 0 262780000.0 25340000.0 106110000.0 131330000.0 False True 34708882.78775146 101421709.34115364 100312558.82625182 1.0 2.92206781651136 2.8901120050355376 25.048801592544024 -10.086281688721373 4.8159597145352055 0.9999244767547067 2.906089910792949 0.9997892426407351 0.01304590547618782 4534371.606374025 0.5808538426746656 3811.788447146675 0.0044659604345554296 8.198196267910512e-11 10.086281688721373 1.9061654340382423 VFLENVIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFLENVIR 8 0 P62805 P62805 HIST1H4A Histone H4 0 148687000.0 60014000.0 55423000.0 33250000.0 False True 49904300.07098968 55124425.298395805 40202421.269370124 1.0 1.104602713994193 0.8055903241240038 25.57266079688449 -6.812177555859215 1.4052284380192885 1.0568624893271428 0.8000876675227976 0.8654742010211871 0.04544117210682618 0.2038415124993381 0.7928869409162611 0.025423220031750092 0.058756914643587115 1.5410702768583616e-07 6.812177555859215 -0.2567748218043452 VFLENVIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFLENVIR 8 0 P62805 P62805 HIST1H4A Histone H4 0 183635000.0 35794000.0 76864000.0 70977000.0 False True 46336038.60522361 72586450.83111376 58059914.28552018 1.0 1.5665225819051967 1.2530185150306505 25.46563137373816 -10.148887877261238 4.560772492416952 0.9999617824183337 1.409770548473752 0.6949262402283569 0.12798749969774034 89521591.72056906 5.333205062622996 50579.84701244296 0.04381352535998257 7.097609848288353e-11 10.148887877261238 0.40980876605541827 VFLFIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFLFIR 6 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 6456000.0 2449300.0 1819300.0 2187400.0 False True 3211056.0190549414 1547867.5315758563 1961068.8310224146 1.0 0.48204314169250007 0.6107239547940321 21.61461640340305 -10.120362923416607 7.731086808516438 1.0000000718022721 0.5463835482433229 0.9430806290618902 0.05253372196420031 6.500813468947929e-08 7.3530036051672336e-09 0.050865565907840915 0.016955185856803223 7.57943925333902e-11 10.120362923416607 -0.4536165235589492 VFLFIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFLFIR 6 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 5170800.0 2153100.0 1273500.0 1744200.0 False True 2084751.019047353 1782015.1912147666 1287341.6951216073 1.0 0.8547856194496912 0.6175038090207389 20.991443662809665 -6.963796105775671 0.3781444513140256 1.0166428561528318 0.4472803205314416 0.9998861372191846 0.0016822614070039531 0.07837189208175534 0.01631514820675305 0.00309415008093736 0.02006812859261816 1.0869358025998874e-07 6.963796105775671 -0.5693625356213902 VFLFIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFLFIR 6 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 10521100.0 2870600.0 3581900.0 4068600.0 False True 4354910.068970828 2942681.959487563 3264439.426669269 1.0 0.6757158960536218 0.7495997333971894 22.054211496095633 -9.961108974828665 5.502907062805554 1.000000551415069 0.7126578147248683 0.9527563713122125 0.03016295029031622 2.040501537165867e-07 3.8513946599690114e-08 0.029205207174097022 0.00973505034529831 1.0936819010025121e-10 9.961108974828665 -0.2873427366902006 VFLFIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFLFIR 6 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 10053100.0 2449300.0 3400400.0 4203400.0 False True 3354872.3998437105 3250159.084380917 3210643.4917404014 1.0 0.9687876905638283 0.9570091225794376 21.677826464925943 -13.999999999999998 0.1351822554964604 1.1485859698203273 0.9415504077524782 0.9996227194300361 0.0003522763540805306 11.93210345163907 0.11481745963562585 0.46911555154901485 0.01377995994123852 1.0000000000000041e-14 13.999999999999998 -0.20703556206784912 VFLFIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFLFIR 6 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 5507900.0 2153100.0 1654100.0 1700700.0 False True 1790398.048502812 1645189.0349868578 2056308.506851661 1.0 0.9188956815288184 1.1485203017123549 20.77184893824394 -6.811228990068036 1.4092414654086076 0.9558627348919843 1.152656183635541 0.8630458079932262 0.03518695086685694 0.20512562285121502 0.8026404847554226 0.019631235717480076 0.045388858153556436 1.544439889356826e-07 6.811228990068036 0.19679344874355664 VFLFIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFLFIR 6 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 14661000.0 2870600.0 6528400.0 5262000.0 False True 3716048.2879855507 6165088.8010751875 4304369.992679421 1.0 1.6590443189362452 1.1583191764746406 21.825337818188082 -10.137118786597519 5.478699747876955 0.9999923455295361 1.4086817477055356 0.4703948866482657 0.20442018340255066 1.9113072839145656e-05 3.0104779647032655e-06 0.1979326970287948 0.06597633049551478 7.29258019056068e-11 10.137118786597519 0.40868940217599947 VFLHLADIYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFLHLADIYAK 11 0 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 0 5723900.0 1481100.0 1495900.0 2746900.0 False True 2028702.69522252 1429806.1917202102 2098138.7941813073 1.0 0.7047884320789453 1.0342268480848895 20.95212602409074 -6.6704942051473 1.9357219449758947 0.8116475674903614 1.032895503515133 0.28121814636561093 0.12538515716527102 0.4599687238809875 3.323274153762723 0.0521394972366274 0.1392088388891232 2.1355305805439286e-07 6.6704942051473 0.22124793602477166 VFLIDLNSTHGTFLGHIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFLIDLNSTHGTFLGHIR 18 0 Q12972 Q12972 PPP1R8 Nuclear inhibitor of protein phosphatase 1;Activator of RNA decay 0 133762000.0 32062000.0 52837000.0 48863000.0 False True 48640398.046172455 43407824.53263474 39205206.632586315 1.0 0.8924232998962995 0.8060215007979648 25.53565169926132 -6.973610329266223 0.14847615995999078 1.1026086745415864 0.5935666566081795 0.9999986034614885 9.359237769183944e-05 0.07514767462879128 0.0045317294116194035 0.004477365843027576 0.010846268789145075 1.0626485910524831e-07 6.973610329266223 -0.5090420179334069 VFLIDLNSTHGTFLGHIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFLIDLNSTHGTFLGHIR 18 0 Q12972 Q12972 PPP1R8 Nuclear inhibitor of protein phosphatase 1;Activator of RNA decay 0 124475000.0 32062000.0 53035000.0 39378000.0 False True 41504891.0365055 50083555.62848824 32211608.052400313 1.0 1.2066904496734472 0.7760918592478341 25.306778021353768 -6.7761524888346925 1.5506155275072964 1.1176160632526124 0.7730683970077399 0.7536392226940685 0.08727672830362936 0.25659026036793037 1.2182501718332825 0.044342036514445834 0.10498076431760679 1.6743548758016488e-07 6.7761524888346925 -0.34454766624487254 VFLISASSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFLISASSK 9 0 B7Z7F3;Q9H6Z4-3;Q9H6Z4-2;Q9H6Z4;K7EIJ4 B7Z7F3 RANBP3 Ran-binding protein 3 0 18979500.0 5184900.0 5917400.0 7877200.0 False True 6797454.1106430255 5034546.985844541 7062142.907437943 1.0 0.7406518534581594 1.0389394017946343 22.69656307602714 -6.676792979921417 1.912828313973413 0.8354447741053871 1.0377907075716677 0.3097505986191451 0.10999447032074838 0.44566144860808354 3.149691535705784 0.04618427124180562 0.12233098669984986 2.1047815107603373e-07 6.676792979921417 0.2023459334662806 VFLISASSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFLISASSK 9 0 B7Z7F3;Q9H6Z4-3;Q9H6Z4-2;Q9H6Z4;K7EIJ4 B7Z7F3 RANBP3 Ran-binding protein 3 0 14993200.0 4743000.0 2666200.0 7584000.0 False True 4592436.061186937 3730827.564049324 5597522.884876894 1.0 0.8123853036475535 1.218857009721805 22.130828204683517 -6.781215405594304 1.531288747983923 0.8939350718470214 1.2221915667444974 0.7716143912095296 0.07938094445165184 0.24869217980029468 1.1519208623633284 0.04082779187742918 0.0962328385228492 1.6549489222357034e-07 6.781215405594304 0.328256494897476 VFLISASSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFLISASSK 9 0 B7Z7F3;Q9H6Z4-3;Q9H6Z4-2;Q9H6Z4;K7EIJ4 B7Z7F3 RANBP3 Ran-binding protein 3 0 20316300.0 5184900.0 4617400.0 10514000.0 False True 7101897.646654003 4413388.000300091 8030809.742627061 1.0 0.6214378494147152 1.1307977307178887 22.75977313755003 -6.707727339090349 1.8037865780003792 0.7667245928315766 1.1294984817910874 0.45411484290549153 0.15958208696196638 0.37964478065302876 2.4065362876996166 0.07044982883323461 0.17943842607750057 1.9600748711913548e-07 6.707727339090349 0.3627738889595108 VFLISASSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFLISASSK 9 0 B7Z7F3;Q9H6Z4-3;Q9H6Z4-2;Q9H6Z4;K7EIJ4 B7Z7F3 RANBP3 Ran-binding protein 3 0 11509400.0 4743000.0 2641200.0 4125200.0 False True 3944014.650526606 2626971.3313628496 4987760.247230242 1.0 0.6660653075951671 1.2646403954316636 21.911233480117794 -6.755320845531143 1.6303283867856206 0.8049056710213255 1.2663176275600736 0.6714867080744698 0.1403742237980095 0.290847135741155 1.5225187000309186 0.06797559169513563 0.1641037888566265 1.756625385065602e-07 6.755320845531143 0.4614119565387481 VFLQLRPEYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFLQLRPEYR 10 1 Q7L8L6 Q7L8L6 FASTKD5 FAST kinase domain-containing protein 5 0 6694800.0 1763700.0 1326800.0 3604300.0 False True 2312227.779695093 1128846.6118258925 3231361.6108869407 1.0 0.48820735644597707 1.3975100720020979 21.14085209538501 -6.753991575477268 1.6351063256431488 0.7005122941725906 1.3998790027772248 0.6659634226809419 0.21511476363172757 0.2931281135651806 1.54307597633563 0.10387666549946427 0.2511334287277196 1.7620102258724506e-07 6.753991575477268 0.6993667086046341 VFLQLRPEYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFLQLRPEYR 10 1 Q7L8L6 Q7L8L6 FASTKD5 FAST kinase domain-containing protein 5 0 6429100.0 1763700.0 1499900.0 3165500.0 False True 2415787.55220036 1433629.458493979 2417874.0955189234 1.0 0.5934418600626504 1.0008637114288723 21.204062156907902 -10.944181727082192 10.624669066446321 1.0517747928787962 0.7971527857457614 0.24841004908372755 0.1663292743178822 0.09854152124485548 0.0005177018113592204 0.07779815171077155 0.05368254245166025 1.1371513542883844e-11 10.944181727082192 -0.25462200713303473 VFLQNLLSVSQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFLQNLLSVSQAR 13 0 P16930;P16930-2;H0YLC7 P16930 FAH Fumarylacetoacetase 0 24059600.0 7454600.0 13022000.0 3583000.0 False True 9773052.79044908 11079168.359358449 3212265.5305629103 1.0 1.1336445834187858 0.32868598987843023 23.220377853902388 -6.86425255046237 1.164138604137622 1.073497876109065 0.2864326983497417 0.9585986609759657 0.07166576556983968 0.14248074107371467 0.36454060591849596 0.04792683820709397 0.11246127578626416 1.3669336966065053e-07 6.86425255046237 -0.7870651777593233 down VFLQNLLSVSQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFLQNLLSVSQAR 13 0 P16930;P16930-2;H0YLC7 P16930 FAH Fumarylacetoacetase 0 56339000.0 24003000.0 16907000.0 15429000.0 False True 23241037.90357791 23658053.268840242 11387682.039921619 1.0 1.017943061191692 0.48998164742756645 24.47017116259723 -6.899029936439374 0.9673530660865495 1.0225387715955228 0.43563693603787884 0.9860782779199386 0.028879767037868282 0.1121237860546719 0.18146245806357789 0.022430656926465377 0.05808353176586434 1.2617405583034551e-07 6.899029936439374 -0.5869018355576439 down VFLQNLLSVSQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFLQNLLSVSQAR 13 0 P16930;P16930-2;H0YLC7 P16930 FAH Fumarylacetoacetase 0 40366800.0 9183800.0 17758000.0 13425000.0 False True 13932496.025713895 14588946.156112721 10771542.865613472 1.0 1.0471164771328323 0.7731236991371432 23.731950406094544 -6.862580360370138 1.1725295400340923 1.0257631609831914 0.7591802830541406 0.9567062410539605 0.02488800369889415 0.14417292033693763 0.37517164868081504 0.016536112741445685 0.03872198322648978 1.372207029005034e-07 6.862580360370138 -0.2665828779290508 VFLQNLLSVSQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFLQNLLSVSQAR 13 0 P16930;P16930-2;H0YLC7 P16930 FAH Fumarylacetoacetase 0 54285600.0 7454600.0 13031000.0 33800000.0 False True 10210767.072990194 12455247.332245538 25817136.132850956 1.0 1.21981504848862 2.5284227862902844 23.28358791542528 -6.936001452405155 0.6957746898922278 0.9838141155848371 2.8433306852065114 0.9975917648722421 0.03310954137373704 0.08963914932576222 0.06327864439881305 0.03132562053539215 0.11475269010430181 1.1587734808781845e-07 6.936001452405155 1.8595165696216744 up VFLQNLLSVSQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFLQNLLSVSQAR 13 0 P16930;P16930-2;H0YLC7 P16930 FAH Fumarylacetoacetase 0 46495000.0 24003000.0 11351000.0 11141000.0 False True 19959558.013196312 11289849.910002911 13470531.589836149 1.0 0.5656362682249075 0.6748912766971129 24.250576438031505 -10.006190345015433 7.088229499700648 1.0000000342871287 0.6202637724610177 0.9415450843887219 0.044603170433393666 2.418191249192385e-08 3.359197309482574e-09 0.043186837930336085 0.014395611356381925 9.858473082554303e-11 10.006190345015433 -0.379736261826111 VFLQNLLSVSQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFLQNLLSVSQAR 13 0 P16930;P16930-2;H0YLC7 P16930 FAH Fumarylacetoacetase 0 40879800.0 9183800.0 18566000.0 13130000.0 False True 11888610.13976232 17532785.779174358 10740474.725176902 1.0 1.4747548765632985 0.9034255980229855 23.503076728186993 -6.6860962887371915 1.8799580086028558 1.2987186098008765 0.9054707783277314 0.35233991128064346 0.20094923644351437 0.4251292877796415 2.909858598342547 0.08560298232944265 0.22404633957355022 2.0601730954507173e-07 6.6860962887371915 -0.3932478314731451 VFLWGSFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFLWGSFR 8 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 49497000.0 15445000.0 20107000.0 13945000.0 False True 20248544.569592744 17107113.976472132 12502105.169885522 1.0 0.8448564743839366 0.6174322864004727 24.271314877507958 -6.965636785131333 0.3469527571242484 1.0227628672910654 0.43188757334751815 0.9999256721816309 0.0013544812494647237 0.0777455627249557 0.014101917938998404 0.0031467852971324003 0.019587887216365084 1.082338768664086e-07 6.965636785131333 -0.5908752939435472 VFLWGSFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFLWGSFR 8 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 41966900.0 18628000.0 8133900.0 15205000.0 False True 18036664.336451665 11381808.687728142 11222354.359777585 1.0 0.6310373401319989 0.6221967737736005 24.10442921842432 VFLWGSFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFLWGSFR 8 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 110512000.0 32215000.0 32356000.0 45941000.0 False True 48872510.23197081 26581819.001418106 36860741.2133444 1.0 0.5439012417256428 0.754222384698204 25.54251987164468 -10.059124375926087 4.844609090041215 1.000008789282866 0.6490618132083859 0.7877859601675397 0.08586324708373974 22415209.68506177 46541913.74047649 1448.383840341475 0.029393274303835253 8.727213972717882e-11 10.059124375926087 -0.3509469760744801 VFLWGSFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFLWGSFR 8 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 61699000.0 15445000.0 22454000.0 23800000.0 False True 21155433.885430954 21461908.034551512 18178930.176386178 1.0 1.0144867815418155 0.8593031121382674 24.33452493903085 -6.884045325810681 1.0569383814537066 1.0095667831070148 0.8474133315771045 0.9768063664839638 0.010659101063080002 0.12410890081636566 0.2511217543591469 0.007737889002254726 0.018920840370210353 1.3060345747142237e-07 6.884045325810681 -0.16215345152991023 VFLWGSFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFLWGSFR 8 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 36700900.0 18628000.0 9663600.0 8409300.0 False True 15490007.360322498 9611540.268725585 10167645.7497899 1.0 0.6204993997191668 0.6564003175256213 23.884834493858595 -9.977192922826395 5.9902251572624765 1.0000002699751822 0.6384498586223346 0.9926593318389884 0.014656488320780212 5.284906672095851e-08 9.019533523302332e-09 0.014191094262225758 0.0047303612649911364 1.053918619370406e-10 9.977192922826395 -0.3615504113528476 VFLWGSFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFLWGSFR 8 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 162300000.0 32215000.0 68064000.0 62021000.0 False True 41702952.55258645 64276178.56693542 50733814.38920004 1.0 1.5412860393010461 1.2165520972460135 25.313646193737128 -10.379910040369063 5.301136501769478 0.9998044017606039 1.3789190682735406 0.6448127708267485 0.13257207669959564 0.0003066263244343078 3.5866793865944646e-05 0.12842788037512776 0.04278745376913346 4.1695574261541527e-11 10.379910040369063 0.3791146665129367 VFMQQLASALQFLHER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFMQQLASALQFLHER 16 0 Q6PHR2-2;Q6PHR2-3;Q6PHR2;Q6PHR2-4 Q6PHR2-2 ULK3 Serine/threonine-protein kinase ULK3 0 13099800.0 7722500.0 4183200.0 1194100.0 False True 9996928.483232912 3950401.2426716625 976786.0525006647 1.0 0.39516149878408857 0.09770861661548882 23.253053469943332 -8.82726802170597 0.3342100617602912 1.1868989251174944 3.392787863111228e-19 0.9981450268051124 0.016168959949558186 0.35318425736339387 0.11174632629256662 0.17162428366690574 0.08655315078234459 1.4884422128324726e-09 8.82726802170597 -1.1868989251174944 VFNCISYSPLCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFNCISYSPLCK 12 0 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 0 32753300.0 8838300.0 11816000.0 12099000.0 False True 11587096.890218956 10053098.858407257 10847111.541803155 1.0 0.8676115297606084 0.9361371225746419 23.466015813237263 -10.220446363256787 5.155003573095735 1.0000094011470584 0.901874326167584 0.7321906393393268 0.02797545611949526 3.0229490664979162e-06 4.5715562403903017e-07 0.027089713942324747 0.009029039637759518 6.019405998784958e-11 10.220446363256787 -0.09813507497947438 VFNCISYSPLCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFNCISYSPLCK 12 0 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 0 22618700.0 8838300.0 6711000.0 7069400.0 False True 12106058.3560767 6414485.829690712 5399753.31886321 1.0 0.5298575011800539 0.44603727819904115 23.529225874760154 -13.999999999999998 0.2425432679631948 4.1506860860027475 0.40986033277389994 0.9995292537698871 0.0052895924811334144 13.71460326859436 0.1558615800483344 20.95978974554858 0.04035458724524333 1.0000000000000041e-14 13.999999999999998 -3.7408257532288474 VFNDMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFNDMK 6 0 P23528;E9PK25;E9PP50;E9PS23;Q9Y281;F8WDN3;G3V2U0 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 0 13316420.0 789720.0 7405400.0 5121300.0 False True 1035330.5676593597 6300543.186023107 4591397.002978469 1.0 6.085537685096232 4.434715970338386 19.981660044468487 -10.50403150064289 6.453291970471156 0.9973159352237947 5.2601268277173086 0.898779241944624 0.6739451429105133 0.026000394607366372 0.0019982549582975135 0.6519126300972973 0.2175148595624829 3.133058466223771e-11 10.50403150064289 4.262810892493514 VFNDMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFNDMK 6 0 P23528;E9PK25;E9PP50;E9PS23;Q9Y281;F8WDN3;G3V2U0 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 0 11073800.0 3394100.0 1576700.0 6103000.0 False True 3286356.153336411 2206284.532381879 4504441.213924537 1.0 0.6713467528898202 1.3706491334943989 21.648057407740282 -6.778908878541553 1.5401548195722268 0.8136448314543919 1.3759971572308622 0.7635003472083817 0.13892023966247735 0.25227282689511443 1.181908824818774 0.07104855674631132 0.16779600208023338 1.6637616957649982e-07 6.778908878541553 0.5623523257764703 VFNDMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFNDMK 6 0 P23528;E9PK25;E9PP50;E9PS23;Q9Y281;F8WDN3;G3V2U0 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 0 16000120.0 789720.0 8755500.0 6454900.0 False True 1081700.8253805481 8368653.059433325 4930385.562838441 1.0 7.736568987537925 4.557993714300721 20.04487010599138 -10.061439623345459 6.074398461409558 0.9999898313731905 6.147281350919485 0.7776032180119836 1.297647921410427 0.00017999332843399407 2.781378772025812e-05 1.2564446421829243 0.4188140657385119 8.68081251629691e-11 10.061439623345459 5.147291519546295 VFNDMK(ub)VR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFNDMKVR 8 1 P23528;E9PK25;E9PP50;E9PS23;Q9Y281;F8WDN3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 1 5570800.0 1695900.0 2197700.0 1677200.0 True False 2223341.3231189596 1869811.7265675056 1503659.4328384358 1.0 0.8409917573719569 0.6763061601036876 21.08429801448217 -6.970684798517507 0.24127063963045728 1.0582099334979076 0.4543171979326944 0.9999872400594217 0.00047203360546710523 0.07608111907939373 0.008231035277305097 0.003901452710827804 0.016019068970063062 1.0698310576185105e-07 6.970684798517507 -0.6038927355652132 VFNDMK(ub)VR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFNDMKVR 8 1 P23528;E9PK25;E9PP50;E9PS23;Q9Y281;F8WDN3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 1 9451900.0 2720100.0 3201700.0 3530100.0 True False 2633751.91440746 4480155.50664493 2605460.9092700277 1.0 1.701054485100535 0.9892582877746869 21.328688027025567 -6.649708619634184 2.009974055842489 1.4550393558749086 0.9922768508034522 0.19266404228892975 0.29924356047847733 0.5092811259525492 3.9435657589396675 0.1207675495368328 0.3313636036826309 2.2402236634452427e-07 6.649708619634184 -0.46276250507145644 VFNDMK(ub)VR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFNDMKVR 8 1 P23528;E9PK25;E9PP50;E9PS23;Q9Y281;F8WDN3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 1 13508500.0 2585100.0 3424400.0 7499000.0 True False 3921785.696125024 2813289.065040682 6016819.363071546 1.0 0.7173490045160785 1.534204015537246 21.90307927171174 -6.813247455568939 1.4007004933492857 0.8465386960920885 1.5496017669314872 0.8681786317215441 0.12297600749380189 0.202398576523584 0.7819844300456855 0.06902044475600358 0.15944711512903392 1.5372784686489723e-07 6.813247455568939 0.7030630708393987 VFNDMK(ub)VR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFNDMKVR 8 1 P23528;E9PK25;E9PP50;E9PS23;Q9Y281;F8WDN3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 1 4392100.0 1695900.0 1587200.0 1109000.0 True False 2322920.059974254 1517072.2558314863 847077.0405719439 1.0 0.653088447584503 0.36466043544405585 21.14750807600506 -7.526310845402136 0.2213935639548823 1.16983423817134 2.11779677397091e-14 0.9999161128163513 0.002378971622145888 0.12911758683627148 0.0219723826396473 0.0314119562757278 0.0676162651521883 2.9763853250418912e-08 7.526310845402136 -1.169834238171319 down VFNDMK(ub)VR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFNDMKVR 8 1 P23528;E9PK25;E9PP50;E9PS23;Q9Y281;F8WDN3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 1 10495200.0 2720100.0 6248000.0 1527100.0 True False 2261883.6708617792 6214340.783869102 1846409.5494873705 1.0 2.7474183858011734 0.8163149914707538 21.109093302459843 -6.668442067809242 1.9431715100452578 2.116894838072317 0.824228320079367 0.27200486459046047 0.742539584087416 0.46473212164965455 3.3816423347098543 0.3078179666081008 0.8240040500080549 2.1456453125060572e-07 6.668442067809242 -1.2926665179929502 VFNDMK(ub)VR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFNDMKVR 8 1 P23528;E9PK25;E9PP50;E9PS23;Q9Y281;F8WDN3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 1 11733200.0 2585100.0 2867400.0 6280700.0 True False 3346462.9099391946 2707826.669352826 5137677.045424104 1.0 0.8091608191175284 1.535255935502795 21.67420559380419 -6.836860390468272 1.2969821580932936 0.8984034937428217 1.5576786066494768 0.9189052049171421 0.08752227078091662 0.17249876549672027 0.565025294629428 0.052941419996360796 0.12187765914242572 1.455927031782435e-07 6.836860390468272 0.6592751129066551 VFNFSTSHIFETR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFNFSTSHIFETR 13 0 Q14997 Q14997 PSME4 Proteasome activator complex subunit 4 0 6595000.0 2319700.0 2378000.0 1897300.0 False True 3041149.1640067575 2023211.6693714005 1700985.5961867184 1.0 0.66527866943093 0.5593233032823834 21.536185149551866 -13.999999999999998 0.16098614120511773 2.651937959086066 0.45628903104370866 0.9995338077944849 0.0040551404760857095 12.016433098795934 0.12682787112964103 6.1978263888765 0.09402432651927496 1.0000000000000041e-14 13.999999999999998 -2.195648928042357 VFNFSTSHIFETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFNFSTSHIFETR 13 0 Q14997 Q14997 PSME4 Proteasome activator complex subunit 4 0 6542670.0 2535700.0 861370.0 3145600.0 False True 2455205.591472006 1205319.5329852079 2321672.9940227782 1.0 0.4909240746159122 0.9456124579085986 21.227412405830876 -10.351500275928204 8.492509463003627 1.000000875882248 0.7182682662622557 0.3385792661621462 0.1856257551730169 3.078345415318839e-06 2.3510306454829806e-07 0.1797319229573346 0.059910454867689145 4.4514318009911796e-11 10.351500275928204 -0.28173260961999236 VFNFSTSHIFETR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFNFSTSHIFETR 13 0 Q14997 Q14997 PSME4 Proteasome activator complex subunit 4 0 7756300.0 2319700.0 2318400.0 3118200.0 False True 3177355.7775354013 2215965.422076434 2381745.3813448464 1.0 0.6974243922395449 0.749599839647894 21.599395211074757 -10.496509067186746 6.16594684488767 1.000217359074531 0.7235121159437246 0.9739867568067304 0.021300537208645765 6.369523647811196e-05 5.201169239344838e-06 0.020640172783878162 0.006874718822863031 3.1877990202318885e-11 10.496509067186746 -0.27670524313080636 VFNIDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFNIDLK 7 0 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 0 8976100.0 1970600.0 3649700.0 3355800.0 False True 2583475.6833175486 3105178.9864191716 3008574.0071066194 1.0 1.2019385382531187 1.1645451228877775 21.300881873941492 -10.078042952783987 4.46826155385342 0.9999860851341265 1.1832418305818797 0.9697137227776214 0.015265797936297731 10603213.401337622 0.026194027476101306 1517.995539146693 0.00522588867424627 8.355203791404524e-11 10.078042952783987 0.18325574544775325 VFNIDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFNIDLK 7 0 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 0 9672800.0 1970600.0 2342500.0 5359700.0 False True 2699184.07346263 2239000.6043883907 4093849.246486423 1.0 0.8295101569401688 1.5166988004766404 21.364091935464383 -6.841037831613061 1.2774927349844971 0.9093085521468572 1.5397789747911168 0.9262298219848148 0.07935546698534213 0.167595206988387 0.5308415574891486 0.04869876041430535 0.1122302607800177 1.4419897335950015e-07 6.841037831613061 0.6304704226442596 VFNLFCLYGNIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFNLFCLYGNIEK 13 0 B7WPG3;C9IYN3;V9GYK2;Q8WVV9-5;Q8WVV9-4;Q8WVV9 B7WPG3 HNRNPLL Heterogeneous nuclear ribonucleoprotein L-like 0 33742000.0 10539000.0 11196000.0 12007000.0 False True 15988433.504104901 9197986.325252736 9633811.187144943 1.0 0.5752900259360135 0.6025487853248124 23.93052525927941 -10.71734395496401 6.788504264930588 1.0049558163506085 0.5889194056304299 0.9967130752876322 0.011128341920642906 0.0008397046926514341 3.496312502101617e-05 0.010839794766509866 0.003591656910795991 1.9171497842838833e-11 10.71734395496401 -0.4160364107201786 VFNTTPDDLDLHVIYDVSHNIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFNTTPDDLDLHVIYDVSHNIAK 23 0 Q9Y3I0 Q9Y3I0 RTCB tRNA-splicing ligase RtcB homolog 0 23314600.0 17088000.0 2979900.0 3246700.0 False True 14209429.126754928 2963846.687236163 3925569.958955302 1.0 0.20858309371877137 0.27626514224725945 23.76034525872582 -10.306411291888569 6.365871283436151 1.0000291158121128 0.24242411840111824 0.9940493563924162 0.027631080606848123 1.1418363922601347e-05 1.2440727530284597e-06 0.026754702183554 0.008917892919003027 4.938427792745637e-11 10.306411291888569 -0.7576049974109946 VFNVFCLYGNVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFNVFCLYGNVEK 13 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 32975600.0 9344800.0 14584000.0 9046800.0 False True 12251123.29517192 12408124.047986763 8110723.919033363 1.0 1.0128152128610701 0.6620392043748137 23.54641069899671 -6.898421039266592 0.9712114141264202 1.0152225231352847 0.6263795393356791 0.9857637914746923 0.019379368069443032 0.1125763341761197 0.18405400176186792 0.01500903098512868 0.03874994045508819 1.2635108066359472e-07 6.898421039266592 -0.3888429837996056 VFNVFCLYGNVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFNVFCLYGNVEK 13 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 51467300.0 34068000.0 9939600.0 7459700.0 False True 32986529.987880405 13908534.114329243 5505780.783796962 1.0 0.42164283783227224 0.16690997161022525 24.97537368604954 -9.584263119811782 0.23741875544043825 1.4604676284786906 1.892382446368189e-21 0.999181781156757 0.009970292007180779 0.9979683443999523 0.09727037638654079 0.45037749542169314 0.11740271867208418 2.6045750750812194e-10 9.584263119811782 -1.4604676284786906 VFNVFCLYGNVEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFNVFCLYGNVEK 13 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 322679000.0 95649000.0 120700000.0 106330000.0 False True 145106525.8785589 99160141.96659562 85313828.8939054 1.0 0.6833610092049459 0.5879392975427266 27.112537162314197 -13.999999999999998 0.16806531051819748 2.588894032548195 0.5020090866093164 0.9995175033032124 0.0038685810414626595 12.073261405905644 0.1297798755600084 6.2530380187589945 0.07918802368685281 1.0000000000000041e-14 13.999999999999998 -2.0868849459388787 VFNVFCLYGNVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFNVFCLYGNVEK 13 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 51856800.0 9344800.0 17069000.0 25443000.0 False True 12799825.09372452 16314835.140365193 19433887.41503334 1.0 1.2746139123701 1.5182932010970491 23.6096207605196 -6.97253589481186 0.1879984695625845 0.8304653823904252 1.969084849245634 0.9999959983632289 0.00042348307895509805 0.0754881270844954 0.0059834549275084485 0.008751619540461995 0.026712798561566373 1.065280813654899e-07 6.97253589481186 1.138619466855209 VFNVFCLYGNVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFNVFCLYGNVEK 13 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 57679500.0 34068000.0 2187500.0 21424000.0 False True 28329051.468298666 2175715.503315247 25903659.346616067 1.0 0.07680156555011942 0.9143849865782937 24.755778961483816 -9.0714757949007 11.711645946737022 1.0000119014585676 0.4955932762376893 0.32594264095926606 0.34194199982472373 0.0 0.0 0.33108391764128203 0.11036130588042732 8.482506577922985e-10 9.0714757949007 -0.5044186252208782 VFNVFCLYGNVEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFNVFCLYGNVEK 13 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2;M0QYT0;M0R076 P14866;M0QYT0 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 283071000.0 95649000.0 77972000.0 109450000.0 False True 123819516.02366415 73632789.65710334 89531223.0518364 1.0 0.5946783836808955 0.7230784445541313 26.883663484406647 -10.810335654206549 10.52708014613272 1.003437933192551 0.658878414117514 0.903945928801493 0.05241910534695444 0.004242755885023498 7.644074008301467e-05 0.05091270447887656 0.016918193502653896 1.547620043797297e-11 10.810335654206549 -0.3445595190750369 VFPLSCAVQQYAWGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFPLSCAVQQYAWGK 15 0 P34949;P34949-2;H3BPP3;H3BUZ9;H3BMZ9;H3BN01;H3BQX0;H3BNY8;H3BUG1;H3BU66 P34949 MPI Mannose-6-phosphate isomerase 0 3052120.0 671450.0 1578400.0 802270.0 False True 880277.4523310493 1342908.87255501 719258.7963172501 1.0 1.5255518234607437 0.8170819261729264 19.74759878911175 -6.708036451596586 1.802234483718819 1.3237430888851218 0.818842536856822 0.4557686362851118 0.22153368141869542 0.37903024722153106 2.3986037103809372 0.0978663246431899 0.2492174354993475 1.9586802688857592e-07 6.708036451596586 -0.5049005520282999 VFPLSCAVQQYAWGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFPLSCAVQQYAWGK 15 0 P34949;P34949-2;H3BPP3;H3BUZ9;H3BMZ9;H3BN01;H3BQX0;H3BNY8;H3BUG1;H3BU66 P34949 MPI Mannose-6-phosphate isomerase 0 5921150.0 671450.0 1430400.0 3819300.0 False True 919703.2102539737 1367200.1982997474 2917260.0009525926 1.0 1.4865667348515599 3.1719580495396973 19.81080885063464 -6.948182173350976 0.5784557427335337 0.9797351276516919 3.7619310683069305 0.9990508052737231 0.028671862004040552 0.08422399444344753 0.03904726679479302 0.030091042480231495 0.14073162460611252 1.1267247302157945e-07 6.948182173350976 2.782195940655239 up VFQFLNAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFQFLNAK 8 0 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 31089700.0 6983700.0 10452000.0 13654000.0 False True 9155698.330247005 8892602.341576898 12241215.058416417 1.0 0.9712642357600473 1.3370050668856157 23.126238497854896 -6.887904231140954 1.0346756002791058 0.9793497270331594 1.3672031176249304 0.9795235544683966 0.023761609738852132 0.12086106999115066 0.23189969024372306 0.017544276803538903 0.043421851090858214 1.294481263740768e-07 6.887904231140954 0.38785339059177104 VFQFLNAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFQFLNAK 8 0 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 24925000.0 11662000.0 4170700.0 9092300.0 False True 11291796.193456046 5836082.259913175 6710753.866846803 1.0 0.516842684717899 0.5943034882914285 23.42877165902714 -10.722944122194193 6.873303779627133 1.0055400174189115 0.5555730865047305 0.9777238175234466 0.03162324063685054 0.0026973515897427062 0.00010872731570107646 0.030764131273921514 0.010206357028302653 1.892587109677849e-11 10.722944122194193 -0.44996693091418105 VFQFLNAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFQFLNAK 8 0 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 39606200.0 8485400.0 25952000.0 5168800.0 False True 12872972.165834693 21320662.83609849 4147184.4144344856 1.0 1.656234672260401 0.3221621519109048 23.61784185171458 -6.772955541393658 1.5630239973603035 1.3749922762097486 0.3137932018760394 0.7417104978018623 0.2768064277136863 0.26171415830524214 1.2622064839711735 0.13955342611401683 0.3313184984847919 1.686725686194297e-07 6.772955541393658 -1.0611990743337092 VFQFLNAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFQFLNAK 8 0 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 31960700.0 6983700.0 13441000.0 11536000.0 False True 9565762.617396202 12847132.176556822 8811434.39137777 1.0 1.343032718917063 0.9211429076604286 23.189448559377787 -6.690435555516859 1.8646012303803399 1.2149658286619445 0.9225816548132548 0.37261860542841785 0.14506491266891472 0.41571474309412904 2.802515216603729 0.06222699863899571 0.16197047256559663 2.0396913047151753e-07 6.690435555516859 -0.29238417384868964 VFQFLNAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFQFLNAK 8 0 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 22190500.0 11662000.0 5999000.0 4529500.0 False True 9697469.71419803 5966682.196291738 5476597.507958257 1.0 0.6152823749019747 0.5647449973409032 23.209176934461418 -13.999999999999998 0.28611038059017485 4.2435336578373475 0.5504256042228575 0.999618766045029 0.0037950628963354903 15.738531892644742 0.1695454288885489 29.978137367426793 0.01942811028398257 1.0000000000000041e-14 13.999999999999998 -3.6931080536144902 VFQFLNAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFQFLNAK 8 0 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 0 19988300.0 8485400.0 6265400.0 5237500.0 False True 10984517.572240157 5916724.982270769 4284328.741288192 1.0 0.5386422246911774 0.3900334004759078 23.38896817380703 -13.999999999999998 0.1584666012178722 3.264914253751356 0.24144340389421998 0.9995404856147081 0.005566991579770633 11.999823692573017 0.12574525740368855 8.354816039816772 0.1351707134630139 1.0000000000000041e-14 13.999999999999998 -3.023470849857136 VFQFLNAK(ub)CESAFLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFQFLNAKCESAFLSK 16 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 25162500.0 2609600.0 5181900.0 17371000.0 True False 3421210.871402348 4408780.718887996 15573615.55439807 1.0 1.2886609111822578 4.55207706855394 21.70607559881748 -6.924272084191324 0.7923940143374777 0.9384639240904374 5.133775550018064 0.9952877212571246 0.11057118557652808 0.0957230753789197 0.09306230377012564 0.09749119641129271 0.30510936646460196 1.1904959322110528e-07 6.924272084191324 4.195311625927626 up VFQFLNAK(ub)CESAFLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFQFLNAKCESAFLSK 16 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 20334700.0 5408600.0 7075300.0 7850800.0 True False 5236906.953517957 9900504.18720208 5794439.961048459 1.0 1.8905251277285524 1.1064622710464567 22.32028354132726 -10.232898861112822 4.414309880226932 0.9998518447942639 1.498493699264136 0.35021041380128837 0.3200923225572933 225743744.06248507 170.0410370651928 469983.60325064964 0.10957611569665958 5.849262864408826e-11 10.232898861112822 0.4986418544698721 VFQFLNAK(ub)CESAFLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFQFLNAKCESAFLSK 16 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 28823700.0 2609600.0 5302100.0 20912000.0 True False 3574439.641788324 5067835.690299979 15973016.296159146 1.0 1.4177986476684485 4.468677022664091 21.769285660340373 -6.9318349509656025 0.7315727719878482 0.956619106009573 5.125316281654451 0.9968867710354858 0.08626730260125222 0.09169611994441842 0.07309398590311666 0.07946963731416919 0.27331958371975457 1.169943931386872e-07 6.9318349509656025 4.168697175644878 up VFQFLNAK(ub)CESAFLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFQFLNAKCESAFLSK 16 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 33810300.0 5408600.0 5138700.0 23263000.0 True False 4497490.541606199 5111016.803147915 28127185.744040772 1.0 1.1364152422036236 6.253973295515959 22.100688816761537 -6.912617236628338 0.877728699194374 0.8543637463779991 6.953723112715518 0.991872206196889 0.22044773395057626 0.10271246905915946 0.12956981725929978 0.18285245069903147 0.5143909208236718 1.2228769621396799e-07 6.912617236628338 6.099359366337519 up VFQFLNAK(ub)CESAFLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFQFLNAKCESAFLSK 16 1 P83731;C9JXB8;C9JNW5 P83731 RPL24 60S ribosomal protein L24 1 77044700.0 11003000.0 56762000.0 9279700.0 True False 14243600.401555428 53603144.80219193 7590889.8177626915 1.0 3.763314280870893 0.5329333598079423 23.7638105313674 -6.6802235872229465 1.9010030316105653 2.748060682560037 0.5452047651278109 0.32510484852878463 1.1711077140855468 0.4380774520274233 3.060996596227582 0.49427546610438017 1.303288029830633 2.0882207782732284e-07 6.6802235872229465 -2.202855917432226 VFQQHYTNK(ub)IR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFQQHYTNKIR 11 1 O43683-2;O43683-3;O43683 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 9028600.0 0.0 2677900.0 6350700.0 True False 0.0 2200007.8224718035 5095481.361389313 0.0 VFQQHYTNK(ub)IR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFQQHYTNKIR 11 1 O43683-2;O43683-3;O43683 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 21162300.0 0.0 6161500.0 15000800.0 True False 0.0 5818607.108606202 12270808.321205895 0.0 VFQSLPHENK(ub)PLTLSNYQTNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFQSLPHENKPLTLSNYQTNK 21 1 P04080;A0A1W2PQG6 P04080 CSTB Cystatin-B 1 32329800.0 9955500.0 14795000.0 7579300.0 True False 9639468.101865182 20702720.654905744 5594053.9558738675 1.0 2.147703632205587 0.580328073785674 23.200522111217968 -6.710499992170337 1.7942498927126784 1.7052543762453198 0.5840835820972489 0.46713718547387173 0.4835994364101248 0.3740502121926717 2.347858340822709 0.21450236366993447 0.5444380035127083 1.947601085054677e-07 6.710499992170337 -1.121170794148071 VFQSLPHENKPLTLSNYQTNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFQSLPHENKPLTLSNYQTNK 21 1 P04080;A0A1W2PQG6 P04080 CSTB Cystatin-B 0 311730000.0 28733000.0 148075000.0 134922000.0 False True 37669241.25076778 125982787.19182925 120961565.7032122 1.0 3.344447167203333 3.2111495131521064 25.16688363843714 -10.092967836627063 5.24103177885723 0.9999598458090984 3.277798340180576 0.9974381028468853 0.054418539399236875 2.553324644611969e-05 4.418600217871886e-06 0.05269143952133018 0.01756350806674342 8.072948154034792e-11 10.092967836627063 2.2778384943714776 VFQSLPHENKPLTLSNYQTNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFQSLPHENKPLTLSNYQTNK 21 1 P04080;A0A1W2PQG6 P04080 CSTB Cystatin-B 0 198805900.0 53869100.0 27582000.0 117354800.0 False True 52159054.90695458 38595636.438229844 86616057.31146494 1.0 0.739960425032236 1.6606140097050734 25.636414393186154 -6.831258684086744 1.3221929828437236 0.8611656349129694 1.6860454540671892 0.9083808399465169 0.11730094954344042 0.17926547593770326 0.6124524605146302 0.06964609280755558 0.16027875281087495 1.4748278020357174e-07 6.831258684086744 0.8248798191542198 VFQSLPHENKPLTLSNYQTNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFQSLPHENKPLTLSNYQTNK 21 1 P04080;A0A1W2PQG6 P04080 CSTB Cystatin-B 0 813883000.0 27096000.0 762670000.0 24117000.0 False True 41106612.98294205 626565579.7320925 19350264.379143413 1.0 15.242452108425898 0.4707336113333678 25.29286716883004 -6.64041154297583 2.042812638110004 9.99999999999854 0.531593536797394 0.22457414902444228 6.025050754702799 0.49937472369285313 3.9832726072944493 2.4221963501252617 6.730397874376277 2.2886978256775058e-07 6.64041154297583 -9.468406463201147 VFQSLPHENKPLTLSNYQTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFQSLPHENKPLTLSNYQTNK 21 1 P04080;A0A1W2PQG6 P04080 CSTB Cystatin-B 0 270725800.0 28733000.0 110156000.0 131836800.0 False True 39356366.58012869 105288943.6828207 100699663.10412559 1.0 2.67527093662101 2.5586625965357674 25.230093699960033 -10.498202896057519 5.477554765509076 0.9971154373507222 2.6169667665783924 0.9961146723798205 0.04760515549364276 0.001677711512698593 0.0001536944186604276 0.046114179549038514 0.01536449786837238 3.175390227989116e-11 10.498202896057519 1.6198513292276702 VFQVEYAMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VFQVEYAMK 9 0 P25788-2;P25788;G3V3W4;G3V5N4 P25788-2 PSMA3 Proteasome subunit alpha type-3 0 45274700.0 13423400.0 14102500.0 17748800.0 False True 17598207.392390512 11998461.971114445 15912324.434511594 1.0 0.6818002370117877 0.9042014382324023 24.068925143197834 -10.115725951937986 5.385926307143296 1.0000035754748693 0.793000837621998 0.5359741411609207 0.09079491019576572 3.898218046102607e-06 6.40066692973446e-07 0.08791331255262186 0.029303931259000687 7.66079865359638e-11 10.115725951937986 -0.20700273785287127 VFQVEYAMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VFQVEYAMK 9 0 P25788-2;P25788;G3V3W4;G3V5N4 P25788-2 PSMA3 Proteasome subunit alpha type-3 0 26841870.0 11780900.0 4344970.0 10716000.0 False True 11406921.77803862 6079939.179719213 7909158.12689093 1.0 0.5330043720843888 0.6933648078588721 23.44340618899236 -10.249284096572673 5.5542410141549645 1.0000261725902757 0.6131845899716161 0.8858191544585232 0.06546687376302368 2.121901465084881e-05 2.8680275229882782e-06 0.06339230966785807 0.021129342651030465 5.6326906914087224e-11 10.249284096572673 -0.38684158261865964 VFQVEYAMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFQVEYAMK 9 0 P25788-2;P25788;G3V3W4;G3V5N4 P25788-2 PSMA3 Proteasome subunit alpha type-3 0 55510400.0 9200400.0 30214000.0 16096000.0 False True 13957679.439336464 24822075.636940494 12914618.544872591 1.0 1.7783812663719203 0.9252697485282368 23.7345557676754 -6.6666409924836305 1.9494076733981498 1.4982711699484228 0.9287742928416486 0.2641873322349324 0.3308986764203071 0.46888446407509843 3.431964585745098 0.13681526479283582 0.3671277039658074 2.1545620574931062e-07 6.6666409924836305 -0.5694968771067742 VFQVEYAMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VFQVEYAMK 9 0 P25788-2;P25788;G3V3W4;G3V5N4 P25788-2 PSMA3 Proteasome subunit alpha type-3 0 43638400.0 13423400.0 15156400.0 15058600.0 False True 18386393.73374517 14486740.132487629 11502068.82160203 1.0 0.7879054665243911 0.6255750305451088 24.132135204720726 -6.974097458108347 0.1264923056800272 1.264862115395065 0.14442795968477132 0.99999930598285 0.00012758656126714236 0.07499413933754173 0.0037864174386011465 0.010618725252285978 0.022582600087858885 1.061457333513858e-07 6.974097458108347 -1.1204341557102937 VFQVEYAMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFQVEYAMK 9 0 P25788-2;P25788;G3V3W4;G3V5N4 P25788-2 PSMA3 Proteasome subunit alpha type-3 0 20074100.0 9204400.0 5807400.0 5062300.0 False True 7653866.424058012 5776114.383521353 6120803.524569386 1.0 0.7546662122774425 0.799700855156052 22.867757292511055 -10.441321212899526 6.007904025165984 1.0000980525174716 0.7771835337167496 0.9702727973631173 0.01838531596684313 2.415710340945837e-05 2.2463682376085467e-06 0.017809306554680576 0.005933835212862039 3.619751752937307e-11 10.441321212899526 -0.222914518800722 VFQVEYAMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFQVEYAMK 9 0 P25788-2;P25788;G3V3W4;G3V5N4 P25788-2 PSMA3 Proteasome subunit alpha type-3 0 48998400.0 9200400.0 23429000.0 16369000.0 False True 11910099.166997248 22125155.55425377 13390009.960123431 1.0 1.8576802127359548 1.1242567985686467 23.50568208976785 -10.19124091449917 4.3136936194369735 0.9998536221330521 1.4909685056704405 0.3740211291092399 0.2994188551841395 210304226.0662991 98.69205314896298 332825.3614852861 0.10249903817883607 6.438120270824783e-11 10.19124091449917 0.4911148835373884 VFSAFITVLQMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFSAFITVLQMK 12 0 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 0 11803900.0 2271700.0 4743800.0 4788400.0 False True 3446334.9835159993 3897231.826521427 3841970.641169724 1.0 1.1308337248590432 1.1147989558606668 21.716631507558308 -10.095561459932656 4.570316657779366 0.999990970044868 1.1228163403637466 0.9873771395255535 0.006546167044839006 774083.1138559026 1711693.2889889453 41.3726050665862 0.002240927260387778 8.024879873649189e-11 10.095561459932656 0.12282537031887852 VFSAFITVLQMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFSAFITVLQMK 12 0 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 0 7522900.0 2271700.0 2866500.0 2384700.0 False True 2940760.4319016137 2706976.7551439865 1950709.069088297 1.0 0.9205023047027149 0.6633349143054439 21.487757829650757 -6.949745485675078 0.5616402245436133 1.0033349817843324 0.5681773485221314 0.9991810901660493 0.004111660653300536 0.08358830092759942 0.036387962813955683 0.004398784254977785 0.02138523975672334 1.1226761957089563e-07 6.949745485675078 -0.435157633262201 VFSATLGLVDIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFSATLGLVDIVK 13 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 17011100.0 7254200.0 8299000.0 1457900.0 False True 9510326.44977273 7060821.549248627 1307050.4931642949 1.0 0.7424373481330244 0.13743487145969943 23.18106343295312 -7.2121847907381245 0.5832726245524539 1.00286756885707 6.728628043015745e-27 0.9980837924879475 0.015826130640975045 0.08896477655283426 0.053027867351928264 0.01566444279177021 0.05311587895360563 6.135009071938597e-08 7.2121847907381245 -1.00286756885707 down VFSATLGLVDIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFSATLGLVDIVK 13 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 65336000.0 36624000.0 15521000.0 13191000.0 False True 35461391.16696405 21718616.24094573 9735881.378482468 1.0 0.6124580995338634 0.274548771441106 25.079745799159678 -7.664071001143002 0.2816106084537936 1.1141691134476188 8.380489653399574e-11 0.9996517295484473 0.005531325482131401 0.12699898437781726 0.03676535287614768 0.034224709714926596 0.07623570484379767 2.1673497441377253e-08 7.664071001143002 -1.1141691133638139 down VFSATLGLVDIVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFSATLGLVDIVK 13 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 151479000.0 35087000.0 57053000.0 59339000.0 False True 53229544.203295246 46871446.392876394 47610620.64079236 1.0 0.8805532170980859 0.8944397580966881 25.665723876943826 -9.983410949500401 5.100735621974012 1.0000007341995207 0.8874964875963783 0.988702474407092 0.005669156626645138 4.733592570404223e-08 9.437207925492526e-09 0.005489173083896608 0.001829712432999513 1.0389366107465135e-10 9.983410949500401 -0.1125042466031424 VFSATLGLVDIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFSATLGLVDIVK 13 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 38913200.0 7254200.0 10862000.0 20797000.0 False True 9936273.77738384 10382080.92416936 15885176.927659767 1.0 1.0448666327814187 1.5987056399166808 23.244273494476012 -6.922989442514271 0.8022396353412717 0.9890460639931048 1.6944625444902195 0.9949719458502124 0.01930662788973473 0.09644449408529335 0.09673130534948828 0.016903649794491108 0.05217708348225586 1.1940171300819522e-07 6.922989442514271 0.7054164804971147 VFSATLGLVDIVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFSATLGLVDIVK 13 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 63017000.0 36624000.0 10686000.0 15707000.0 False True 30454478.718297806 10628432.396995079 18991261.07903747 1.0 0.3489940673523744 0.6235950138797499 24.860151074593954 -10.398608273096334 5.979855661289607 1.0001301602752777 0.4862945406161541 0.823514773533719 0.11210536697956065 0.0001945833964417168 1.956935308702535e-05 0.10857270469833513 0.03618185161102561 3.9938497901809466e-11 10.398608273096334 -0.5138356196591236 VFSATLGLVDIVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFSATLGLVDIVK 13 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 120810000.0 35087000.0 42651000.0 43072000.0 False True 45420813.168170035 40277434.35675782 35233337.95604107 1.0 0.886761630788755 0.7757090967436017 25.436850199036275 -6.97136528163145 0.2231973734969312 1.0491891555629536 0.6101340753326336 0.9999911554228417 0.00027225998798007694 0.07586227695068465 0.0074255172184330654 0.003002132577011983 0.011180804791460842 1.0681560837120068e-07 6.97136528163145 -0.4390550802303199 VFSDEVQQQAQLSTIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFSDEVQQQAQLSTIR 16 0 B0QY89;Q9Y262;Q9Y262-2;B0QY90 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 5733000.0 0.0 3560700.0 2172300.0 False True 0.0 3029457.439499893 1947531.2341729878 0.0 VFSDEVQQQAQLSTIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFSDEVQQQAQLSTIR 16 0 B0QY89;Q9Y262;Q9Y262-2;B0QY90 B0QY89 EIF3L Eukaryotic translation initiation factor 3 subunit L 0 3729000.0 0.0 1942600.0 1786400.0 False True 0.0 1856769.5086808512 1364489.1120628668 0.0 VFSGLVSTGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFSGLVSTGLK 11 0 P13639 P13639 EEF2 Elongation factor 2 0 353156000.0 94956000.0 112330000.0 145870000.0 False True 124488235.55521215 95570801.85891047 130776771.68384378 1.0 0.7677095063053052 1.0505151037010447 26.89143416960028 -6.688467191686938 1.871974843532245 0.8541572079285036 1.0495164192150312 0.36317809350043884 0.09827376854556891 0.41998958207582016 2.8523128286473627 0.04201705957007412 0.1096226847275027 2.0489568303677314e-07 6.688467191686938 0.19535921128652767 VFSGLVSTGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFSGLVSTGLK 11 0 P13639 P13639 EEF2 Elongation factor 2 0 241207000.0 79104000.0 30803000.0 131300000.0 False True 76592886.81934053 43102798.535522975 96908591.08443244 1.0 0.5627519777024392 1.2652427021455728 26.190707079508368 -6.738395349553554 1.6927015146663116 0.7393544577990192 1.2655014394920325 0.5976592945786405 0.18372092539212345 0.32072815963812906 1.803785883475438 0.08588795873635398 0.2111231052578458 1.8264368062438436e-07 6.738395349553554 0.5261469816930133 VFSGLVSTGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFSGLVSTGLK 11 0 P13639 P13639 EEF2 Elongation factor 2 0 376590000.0 101950000.0 174380000.0 100260000.0 False True 154665603.54336223 143260526.56284142 80443567.05448087 1.0 0.9262597712792472 0.520112844818322 27.204577147127203 -6.9376724253198665 0.6808708492256997 1.0047943747777468 0.41770079185529446 0.9978428973196907 0.009799759564147323 0.08884467592601049 0.05956616242220627 0.009378823788263104 0.03532966349334666 1.1543235995610136e-07 6.9376724253198665 -0.5870935829224524 VFSGLVSTGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFSGLVSTGLK 11 0 P13639 P13639 EEF2 Elongation factor 2 0 276204000.0 94956000.0 77728000.0 103520000.0 False True 130063799.28941308 74293719.94787666 79070708.0613233 1.0 0.5712098243613587 0.6079378619824731 26.954644231123172 -10.641139336191097 5.7094716577670255 1.0036671632299154 0.5895738431719174 0.9940298377248462 0.014994158570912549 0.0007045355455775923 4.428252447757722e-05 0.014613714016676733 0.004839343869628108 2.2848656244772453e-11 10.641139336191097 -0.41409332005799804 VFSGLVSTGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFSGLVSTGLK 11 0 P13639 P13639 EEF2 Elongation factor 2 0 169125000.0 79104000.0 55765000.0 34256000.0 False True 65778480.9013825 55464582.876514114 41418771.218151644 1.0 0.843202550689315 0.6296705343537529 25.971112354942644 -6.966813246320742 0.3254324088291213 1.0274401934876438 0.4384900008034833 0.9999457905259025 0.001117472055526825 0.07735091269679262 0.012718478483484136 0.0031685215989630732 0.018694928164447375 1.0794107866106989e-07 6.966813246320742 -0.5889501926841605 VFSGLVSTGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFSGLVSTGLK 11 0 P13639 P13639 EEF2 Elongation factor 2 0 358423000.0 101950000.0 170950000.0 85523000.0 False True 131976284.73494272 161436482.2228726 69958691.54008405 1.0 1.2232234188672373 0.5300853231365545 26.975703469219653 -6.820024644699586 1.3717314609686633 1.1203138283311986 0.5149409827270194 0.8844467398065836 0.09820091247964581 0.1934501823228492 0.715237762216234 0.056255935840278395 0.12966231122146268 1.5134753615426624e-07 6.820024644699586 -0.6053728456041793 VFSIGPVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFSIGPVFR 9 0 P14868;P14868-2 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 49882000.0 15027000.0 13202000.0 21653000.0 False True 19700542.521675017 11232313.060992947 19412555.270242453 1.0 0.5701524741582564 0.9853817603695069 24.231732023972018 -10.74124806983492 9.966267915265464 1.0005861614574576 0.7777671182477394 0.2763723425438177 0.16951664624627308 0.002213246536692379 5.746216779641392e-05 0.1645369778136756 0.054711262318062455 1.8144789328892114e-11 10.74124806983492 -0.22281904320971824 VFSIGPVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFSIGPVFR 9 0 P14868;P14868-2 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 37082100.0 15139000.0 5555100.0 16388000.0 False True 14658420.731669642 7773280.399463796 12095491.170538293 1.0 0.5302945345721697 0.8251565016418093 23.805226343036654 -10.490833166550294 6.036090245932778 1.0002721754577144 0.6777255181069903 0.6143121005446452 0.12037689397899239 0.000441275666198935 3.722313140139677e-05 0.11665118611617584 0.03885147547073443 3.2297345802090925e-11 10.490833166550294 -0.3225466573507241 VFSIGPVFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFSIGPVFR 9 0 P14868;P14868-2 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 25557100.0 8079100.0 12421000.0 5057000.0 False True 12256585.361325927 10204375.504284048 4057481.7334381645 1.0 0.8325626757744974 0.3310450352869915 23.547053769794907 -6.951486092736049 0.5422818474002443 1.0072748288542814 0.1330819759483785 0.9993128145103207 0.007450741920821081 0.08289440662171527 0.03353454748567925 0.008169529186768509 0.041548200883617034 1.1181856312876899e-07 6.951486092736049 -0.8741928529059029 down VFSIGPVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFSIGPVFR 9 0 P14868;P14868-2 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 46537000.0 15027000.0 14447000.0 17063000.0 False True 20582887.989405725 13808683.770159692 13033070.823515838 1.0 0.6708817429928782 0.6331993270441022 24.29494208549491 -13.999999999999998 0.3058872508218755 4.106000367624959 0.624481113478272 0.9996629200609559 0.0030247516287628565 16.982391580155543 0.17583376804847548 33.495704976786975 0.01328263285168432 1.0000000000000041e-14 13.999999999999998 -3.481519254146687 VFSIGPVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFSIGPVFR 9 0 P14868;P14868-2 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 31472800.0 15139000.0 8470300.0 7863500.0 False True 12588749.271415211 8424668.812677085 9507721.49328397 1.0 0.6692220673428342 0.7552554497906149 23.58563161847093 -9.891490317282116 6.338049523083476 1.0000000271170868 0.7122387585666915 0.9371724415202634 0.03512298130725084 1.347383480570445e-08 2.318673345014342e-09 0.03400768345849924 0.011335893472660327 1.2838363936476503e-10 9.891490317282116 -0.2877612685503953 VFSIGPVFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFSIGPVFR 9 0 P14868;P14868-2 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 32943100.0 8079100.0 11723000.0 13141000.0 False True 10458554.2128698 11070604.74465479 10749472.838046432 1.0 1.0585215240393198 1.0278163328558971 23.318180091887356 -10.142789573948408 4.269954185875346 0.9999906006868934 1.043168928450124 0.7249321688438448 0.0125353418215096 1.1266143260485481e-06 2.261971744636114e-07 0.012139946239363384 0.004045764174405547 7.197976526846571e-11 10.142789573948408 0.043178327763230606 VFSK(ub)QPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFSKQPGR 8 1 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 1 3512300.0 1138600.0 1159900.0 1213800.0 True False 1102455.7662381306 1623054.1187985912 895869.3667805346 1.0 1.4722169981811417 0.81261252760959 20.072289341107776 -6.714518048430817 1.7789168405872395 1.2889587141710313 0.8139354781695559 0.4865812397743726 0.19885565328390958 0.3660827921596417 2.2608959323098134 0.0888623952630421 0.2245395303344227 1.929665141407198e-07 6.714518048430817 -0.47502323600147534 VFSLSSEFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFSLSSEFK 9 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 9982500.0 3519100.0 4343900.0 2119500.0 False True 4613574.17901288 3695807.052389582 1900194.471679624 1.0 0.8010724243259782 0.4118703629657884 22.137453422461654 -6.9604727368780175 0.428720807579796 1.0156710964560187 0.1823779361872903 0.9997873282450375 0.0035620396548017227 0.07953269659983306 0.020510666196140687 0.0050690083137277415 0.03232551895511144 1.0952853104649931e-07 6.9604727368780175 -0.8332931602687284 down VFSLSSEFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFSLSSEFK 9 0 O75643;A0A494C1A5 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 6296400.0 3519100.0 2777300.0 0.0 False True 4820206.370101663 2654589.7026970657 0.0 1.0 0.5507211722640576 0.0 22.200663483984545 -7.780518896254321 0.6258366136746335 1.003606186561621 2.956695394389586e-19 0.9879338796396235 0.044921244351986134 0.11760370455392163 0.15483555757899653 0.04325972586977134 0.0779023444965651 1.6576052124899494e-08 7.780518896254321 -1.003606186561621 down VFSSSQGVEQVVLGLYIVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFSSSQGVEQVVLGLYIVR 19 0 F2Z2Y6;O95777;C9JIZ0;C9JNV3 F2Z2Y6 LSM8 U6 snRNA-associated Sm-like protein LSm8 0 89257000.0 18718000.0 43260000.0 27279000.0 False True 28396574.469099104 35539915.00807726 21887293.69318957 1.0 1.2515564173682805 0.7707723238592431 24.75921356948684 -6.764492990866003 1.5952470600898094 1.145294323440055 0.7685942274905653 0.7091861288356798 0.10588588939910178 0.27541641230715874 1.3822406119384598 0.052344164942168016 0.1252553295161734 1.719915098943243e-07 6.764492990866003 -0.3767000959494897 VFSSSQGVEQVVLGLYIVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFSSSQGVEQVVLGLYIVR 19 0 F2Z2Y6;O95777;C9JIZ0;C9JNV3 F2Z2Y6 LSM8 U6 snRNA-associated Sm-like protein LSm8 0 56899000.0 18718000.0 16414000.0 21767000.0 False True 24230819.986941226 15500546.470934391 17805629.34828069 1.0 0.6397037524643465 0.7348339576570962 24.53033989157929 -10.004474611975501 6.902768112620314 1.0000000420039599 0.6872688550607221 0.9351042995736496 0.03883674364141844 2.5147842346468233e-08 3.5717254319325447e-09 0.037603520379041994 0.01253450511201142 9.897497210530313e-11 10.004474611975501 -0.31273118694323776 VFSWGFGGYGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFSWGFGGYGR 11 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 80276000.0 33174000.0 34857000.0 12245000.0 False True 43491435.257473 29656471.47152181 10978004.862334035 1.0 0.681892223053872 0.25241762653596767 25.374227984065985 -7.243070487804766 0.3796154845341033 1.0365772968822287 1.2591560644516981e-13 0.9996924156198899 0.005372367379387632 0.0948138184187904 0.025909241643757252 0.010050996048804358 0.046714677705353924 5.71385890833653e-08 7.243070487804766 -1.0365772968821028 down VFSWGFGGYGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFSWGFGGYGR 11 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 58496000.0 33569000.0 11225000.0 13702000.0 False True 32503370.469741568 15707201.037601711 10113035.14881108 1.0 0.4832483773405607 0.3111380451521367 24.95408599182521 -13.999999999999998 0.1536133070147683 3.51363723446509 0.12942903652376064 0.9995546304631243 0.00617757598897873 11.973131112275036 0.12360985417625267 8.97519270558612 0.16438558126314953 1.0000000000000041e-14 13.999999999999998 -3.3842081979413297 VFSWGFGGYGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFSWGFGGYGR 11 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 89403000.0 30449000.0 26406000.0 32548000.0 False True 46193359.12007695 21693642.98898031 26114873.53370484 1.0 0.469626877157579 0.565338265741202 25.461182125091458 -10.266693051960374 7.207477673015139 1.000002501609193 0.5174825714495027 0.9713363085319175 0.039074010767186605 1.5707592385468527e-06 1.598024031785198e-07 0.03783344436565119 0.01261108274757025 5.411366491239919e-11 10.266693051960374 -0.4825199301596902 VFSWGFGGYGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFSWGFGGYGR 11 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 92192000.0 33174000.0 32571000.0 26447000.0 False True 45439324.293641135 31131905.522106446 20200763.29306237 1.0 0.6851313483652112 0.44456566216785276 25.437438045588877 -7.534279360042537 0.169468732096839 1.2584353619054987 5.325874533374129e-12 0.9999727777237947 0.0011866035893686238 0.132096796028981 0.016226673995403337 0.03917346045430456 0.07001428291309132 2.9222720208730603e-08 7.534279360042537 -1.2584353619001727 down VFSWGFGGYGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFSWGFGGYGR 11 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 65649000.0 33569000.0 19523000.0 12557000.0 False True 27914110.858850434 19417825.723987903 15182610.642991891 1.0 0.6956275921585121 0.5439045047776652 24.734491267259486 -13.999999999979437 0.09052774386810247 2.5549919538028454 0.1674590372739639 0.9998399309704284 0.002399345589237516 12.159016630507404 0.08754999217299582 3.632038429815966 0.3380678467446235 1.0000000000473484e-14 13.999999999979437 -2.3875329165288814 VFSWGFGGYGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFSWGFGGYGR 11 0 Q9P258 Q9P258 RCC2 Protein RCC2 0 186057000.0 30449000.0 85502000.0 70106000.0 False True 39416830.7395221 80743738.53770147 57347427.34830553 1.0 2.0484584128866072 1.45489696336253 25.232308447183907 -10.579731162776588 6.3854098696103705 0.9984424596882343 1.7516776881243048 0.6813571708938377 0.2423204470534572 0.005381383193180501 0.00035418620649988104 0.23498821426048633 0.07820858799029792 2.631896685966928e-11 10.579731162776588 0.7532352284360705 VFTASCDK(ub)TAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFTASCDKTAK 11 1 P78406;E9PQ57;E9PPG9;B0QZ36 P78406 RAE1 mRNA export factor 1 13298820.0 673020.0 1673800.0 10952000.0 True False 1021020.5443526608 1375097.312540911 8787332.399567878 1.0 1.3467871142717691 8.606420750465068 19.96158046486164 -6.916856432079181 0.8477070266121318 0.8209637381557294 9.69647440681369 0.9932623417141541 0.2878512774241328 0.10005712093584808 0.11545713734616475 0.24396981128019077 0.7102245158776272 1.2109983960338142e-07 6.916856432079181 8.875510668657961 up VFTK(ub)ELDQWIEQLNECK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFTKELDQWIEQLNECK 17 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 8407900.0 2561700.0 5846200.0 0.0 True False 3358413.507538093 4973969.748309112 0.0 1.0 1.4810474461065735 0.0 21.679348443597558 -6.841170013942072 1.4265289961288405 1.2579141208222953 8.688066028599435e-21 0.8818913103251723 0.21200404018399857 0.18321302338865655 0.7486512843130563 0.11922069232973123 0.25467933394641995 1.4415509148537436e-07 6.841170013942072 -1.2579141208222953 down VFTK(ub)ELDQWIEQLNECK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFTKELDQWIEQLNECK 17 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 39210000.0 24218000.0 7260100.0 7731900.0 True False 23449212.84626296 10159095.790921332 5706683.437971996 1.0 0.43323824375368575 0.24336353955188117 24.483036158728172 -13.999999999999998 0.1527608655028215 3.752837318802015 0.04095210798039027 0.999557287311966 0.006762812425462783 11.96916595206526 0.12322784352872607 9.773321232656826 0.1829493616638899 1.0000000000000041e-14 13.999999999999998 -3.7118852108216247 VFTK(ub)ELDQWIEQLNECK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFTKELDQWIEQLNECK 17 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 213624200.0 77510200.0 82068000.0 54046000.0 True False 117588640.15465143 67422324.19978936 43363784.41079669 1.0 0.5733744697711971 0.3687752860630505 26.809173452060953 -12.091625604159896 0.11863581191117341 2.34675573575461 4.208604483790307e-24 0.9997667576888069 0.004015938305948316 5.762803275168715 0.08527640933220541 2.2079271898318016 0.28023042631372397 8.097937039176845e-13 12.091625604159896 -2.34675573575461 VFTK(ub)ELDQWIEQLNECK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFTKELDQWIEQLNECK 17 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 6772600.0 2561700.0 1314800.0 2896100.0 True False 3508829.717339501 1256707.7885378257 2212100.8270517653 1.0 0.3581558211068444 0.6304383527420208 21.74255850512045 -10.394878491340583 5.97247979420577 1.0001229757477264 0.4942970869245006 0.8214056891634698 0.11115887806323446 0.00018206412497203997 1.844628654414849e-05 0.10765498250109418 0.035876373626833824 4.028297238830381e-11 10.394878491340583 -0.5058258888232258 VFTK(ub)ELDQWIEQLNECK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFTKELDQWIEQLNECK 17 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 47522100.0 24218000.0 8448100.0 14856000.0 True False 20138340.039311267 8402588.408483438 17962320.913616896 1.0 0.41724334737029334 0.8919464503307298 24.26344143416245 -10.068819905363243 7.289408105165334 1.0000000563088955 0.6545948988505217 0.4138041428385022 0.1937967302614895 1.7744943664902347e-07 2.2631434676205343e-08 0.18764290796994712 0.0625476257376833 8.53453953685523e-11 10.068819905363243 -0.34540515745837386 VFTK(ub)ELDQWIEQLNECK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFTKELDQWIEQLNECK 17 1 P67775;P67775-2 P67775 PPP2CA Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform 1 205819800.0 77510200.0 67622300.0 60687300.0 True False 100338481.85446157 63859059.56022089 49642834.10428236 1.0 0.6364363739611573 0.4947536895793185 26.580299774153403 -13.999999999997964 0.13033340661165208 2.727821180049157 0.29717443151441836 0.999644109298918 0.00401434276457863 11.936213489547743 0.11230052241438425 5.281657851752483 0.17573511577200976 1.0000000000046874e-14 13.999999999997964 -2.4306467485347385 VFTSSTISGGYAEYALAADHTVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFTSSTISGGYAEYALAADHTVYK 24 0 Q08257-3;Q08257;C9JH92;A6NP24 Q08257-3 CRYZ Quinone oxidoreductase 0 7647500.0 2206600.0 1736500.0 3704400.0 False True 2136552.6908317716 2429893.505727868 2734106.5103821154 1.0 1.1372963167044092 1.2796812931946522 21.026853465966106 -6.970668104900267 0.24169727676532282 0.9499377076015774 1.4711668471208685 0.9999871321339188 0.0004095640927369258 0.07608651116699001 0.00825063721190451 0.003363036791417598 0.013839490811596319 1.0698721810823781e-07 6.970668104900267 0.5212291395192912 VFVHYTGWLLDGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFVHYTGWLLDGTK 14 0 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 55065000.0 15819000.0 35706600.0 3539400.0 False True 20738862.191413935 30379314.46323668 3173176.8403221825 1.0 1.464849623033513 0.15300631302887507 24.30583340909395 -6.810919096392439 1.4106428651627283 1.2530656660719839 0.12956553568755808 0.8622173351065285 0.2015860880007501 0.2055513798646212 0.8059832803465393 0.11235964965077572 0.2598072491025042 1.545542327847402e-07 6.810919096392439 -1.1235001303844259 down VFVHYTGWLLDGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFVHYTGWLLDGTK 14 0 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 125207700.0 68050400.0 34196300.0 22961000.0 False True 65890177.30090568 47851060.921348624 16946825.284765057 1.0 0.7262244978158663 0.25719805256210954 25.97356007306376 -7.08508285062485 0.4210151924823744 1.02211377105293 2.1375718445253802e-11 0.9997874652723264 0.004471533248562761 0.07513154540581321 0.020999110932617634 0.006715191210426733 0.03744431999150629 8.220858051732718e-08 7.08508285062485 -1.0221137710315542 down VFVHYTGWLLDGTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFVHYTGWLLDGTK 14 0 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 286971600.0 71224600.0 102326000.0 113421000.0 False True 108052925.4157389 84065125.82331291 91003289.63580981 1.0 0.7779995358743712 0.842210326889996 26.687162891228258 -9.911823028623438 6.09380713352308 1.0000000443989905 0.8101049313821349 0.9210196846424444 0.026213945661634645 1.583554118219403e-08 2.792943558360119e-09 0.02538154979782064 0.008460514582132657 1.2251153218322953e-10 9.911823028623438 -0.18989511301685558 VFVHYTGWLLDGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFVHYTGWLLDGTK 14 0 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 122121300.0 15819000.0 34286400.0 72015900.0 False True 21667711.792400967 32771513.478037182 55007227.6340172 1.0 1.5124584354832706 2.538672664702355 24.36904347061684 -6.960020037510471 0.43515074651143254 0.9613955328978081 3.1294257931907565 0.9997709432850812 0.009682006278320398 0.07969395863853737 0.021104819638836918 0.01345306850372687 0.08511062108886931 1.0964276079192557e-07 6.960020037510471 2.1680302602929484 VFVHYTGWLLDGTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFVHYTGWLLDGTK 14 0 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 119129600.0 68050400.0 25062400.0 26016800.0 False True 56586922.74387431 24927383.876703106 31456792.5919082 1.0 0.44051492231748124 0.5559021601914814 25.753965348498035 -9.96806212397791 5.960689001234105 1.0000003543745342 0.49820854125461006 0.9618548071272948 0.04710664260378825 2.2180015079291162e-07 3.8425714236862736e-08 0.04561084251752826 0.01520360352496236 1.0763112408737324e-10 9.96806212397791 -0.5017918131199242 VFVHYTGWLLDGTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFVHYTGWLLDGTK 14 0 Q02790;F5H1U3 Q02790 FKBP4 Peptidyl-prolyl cis-trans isomerase FKBP4;Peptidyl-prolyl cis-trans isomerase FKBP4, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 269525000.0 71224600.0 118581000.0 79719400.0 False True 92201648.74676235 111981863.10892347 65211287.190119326 1.0 1.2145321112043097 0.7072681245562782 26.458289213320707 -6.791798252388525 1.4890547998688846 1.1196226010972286 0.7015963311268523 0.8071194972293043 0.09130950314041891 0.23268355333920665 1.0191654888935557 0.04826054551520353 0.11284773535381643 1.6151086668487695e-07 6.791798252388525 -0.4180262699703763 VFVMPNGMLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFVMPNGMLK 10 0 P61289;P61289-3;P61289-2;K7ESG5;K9J957;B3KQ25;K7ENH2;K7EMD0;K7EPX6;K7EKR3 P61289 PSME3 Proteasome activator complex subunit 3 0 6637800.0 1799900.0 2197300.0 2640600.0 False True 2359686.3302563955 1869471.405008317 2367376.042423785 1.0 0.7922541996525388 1.0032587857414736 21.17016366625904 -11.010913244038347 9.5239551899214 1.1298891832852198 0.8977564926970029 0.2384196947848648 0.08614226155084265 0.06020675131425848 6.898930772571901e-05 0.021136801801814913 0.02780229536592143 9.751844240117137e-12 11.010913244038347 -0.23213269058821695 VFVMPNGMLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFVMPNGMLK 10 0 P61289;P61289-3;P61289-2;K7ESG5;K9J957;B3KQ25;K7ENH2;K7EMD0;K7EPX6;K7EKR3 P61289 PSME3 Proteasome activator complex subunit 3 0 7860900.0 1799900.0 3417500.0 2643500.0 False True 2465371.6704685804 3266503.5498387716 2019159.744591463 1.0 1.324953794580565 0.8190082529048011 21.23337372778193 -6.733251105879439 1.7111268235299082 1.1948477445560106 0.8191142095447861 0.5742985365833055 0.13657253112785417 0.3302183331294607 1.8955554577210578 0.06320862048876012 0.15628884683153774 1.84819969449783e-07 6.733251105879439 -0.37573353501122453 VFVVGVGMTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFVVGVGMTK 10 0 P22307-7;P22307-8;P22307;E9PLD1;P22307-3 P22307-7 SCP2 Non-specific lipid-transfer protein 0 10908600.0 3102800.0 2688300.0 5117500.0 False True 4067800.8475579373 2287216.118911328 4587990.190526288 1.0 0.5622733768504018 1.1278797469351631 21.95581761841298 -6.700048851314815 1.8304564899767863 0.7282090292317553 1.126213018680567 0.4179410311389783 0.18476728062793218 0.3954089200764827 2.575669712793736 0.08052310098628372 0.2070900466905166 1.9950378918878502e-07 6.700048851314815 0.39800398944881166 VFWDPSVNLFGHVGSTTASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFWDPSVNLFGHVGSTTASR 20 0 R4GMQ1;O60341;O60341-2;R4GMP9 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 7357700.0 3372100.0 1633400.0 2352200.0 False True 3265054.5312942206 2285625.138068475 1736088.2555125833 1.0 0.7000266354395269 0.5317179970113464 21.63867565646212 -12.198170438852463 0.08197845566829909 2.2533998519054554 1.0795537141141831e-13 0.9999194894907808 0.0017378158700521245 6.224619369513643 0.06329026943302513 1.7572177699881313 0.40243189496924586 6.336209979204596e-13 12.198170438852463 -2.2533998519053475 VFWDPSVNLFGHVGSTTASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFWDPSVNLFGHVGSTTASR 20 0 R4GMQ1;O60341;O60341-2;R4GMP9 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 6505300.0 3372100.0 1306300.0 1826900.0 False True 2804050.559359221 1299262.70261975 2208896.343368788 1.0 0.4633520955187971 0.7877519668809263 21.419080931896396 -10.380037470188151 5.992179796606763 1.0000721879208192 0.6255520311998684 0.6398317425679526 0.13243569291028714 0.0001277436452653278 1.3216558352644088e-05 0.12825490077688229 0.04274343609041503 4.1683341824152784e-11 10.380037470188151 -0.37452015672095085 VFYELQHSDK(ub)PVGTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFYELQHSDKPVGTK 15 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 16217300.0 3110800.0 5494300.0 7612200.0 True False 4026991.9230354126 5188537.375122139 6226857.707767829 1.0 1.28843997561614 1.546280158186717 21.941271147987667 -6.972452893752255 0.19070924709743972 0.8268614486473959 2.014907642458477 0.9999957284056331 0.0004611346540483026 0.07551454248783522 0.006089095364324967 0.009048033462414522 0.028052398292103847 1.0654844263871855e-07 6.972452893752255 1.1880461938110813 VFYIGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFYIGLR 7 0 Q9GZP4-2;Q9GZP4;X6R8S9 Q9GZP4-2 PITHD1 PITH domain-containing protein 1 0 17772800.0 4779600.0 7549800.0 5443400.0 False True 6266101.885712248 6423399.268889899 4880169.184779841 1.0 1.0251029086418648 0.7788205927368396 22.57913679719094 -6.881782394028861 1.0698589369131801 1.0159553789297546 0.7607625620609898 0.975092858100948 0.017463940216354393 0.1260606452919367 0.26287187007625523 0.012554050290173743 0.030499853187702156 1.3128575497461695e-07 6.881782394028861 -0.2551928168687648 VFYIGLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFYIGLR 7 0 Q9GZP4-2;Q9GZP4;X6R8S9 Q9GZP4-2 PITHD1 PITH domain-containing protein 1 0 17653600.0 6507800.0 4650100.0 6495700.0 False True 6301213.451189616 6506909.179951143 4794281.303177063 1.0 1.0326438281062664 0.760850483849574 22.587198250546052 -6.876902708854893 1.09698457655072 1.019508638329817 0.7427013359342282 0.9710974387395419 0.02059904905739842 0.13040627772657387 0.28919867108281855 0.014503606593915296 0.03481192038148025 1.3276918554603704e-07 6.876902708854893 -0.27680730239558893 VFYIGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFYIGLR 7 0 Q9GZP4-2;Q9GZP4;X6R8S9 Q9GZP4-2 PITHD1 PITH domain-containing protein 1 0 25584300.0 7291800.0 7912500.0 10380000.0 False True 11062193.701986166 6500452.554355324 8328388.450284381 1.0 0.5876278005499215 0.752869518890187 23.39913417357727 -10.118323644204565 5.1810562483488445 1.0000089160352579 0.6702486597196456 0.841514622181406 0.06745964902715008 6.947831711261248e-06 1.1822592981291118e-06 0.06531929013156972 0.021772508101724097 7.615113063430588e-11 10.118323644204565 -0.32976025631561223 VFYIGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFYIGLR 7 0 Q9GZP4-2;Q9GZP4;X6R8S9 Q9GZP4-2 PITHD1 PITH domain-containing protein 1 0 17329600.0 4779600.0 5345900.0 7204100.0 False True 6546747.283833344 5109700.461472749 5502639.953096789 1.0 0.7804945326193873 0.8405151007867844 22.642346858713832 -10.286981918098906 9.508779351218704 1.0000000314533248 0.8105048167030858 0.9300224739212138 0.024503294347009617 1.6324354188105174e-08 1.2455191550718192e-09 0.023725216798917977 0.007908404244432208 5.1643787077506995e-11 10.286981918098906 -0.189495214750239 VFYIGLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFYIGLR 7 0 Q9GZP4-2;Q9GZP4;X6R8S9 Q9GZP4-2 PITHD1 PITH domain-containing protein 1 0 12576600.0 6507800.0 2967200.0 3101600.0 False True 5411524.044422738 2951215.104656913 3750130.219821902 1.0 0.5453574779360935 0.6929896622536283 22.36760352598033 -10.363448324258378 5.001622081567637 1.0002494228078704 0.6191735700947932 0.8987053469866586 0.06027058686531442 0.0001677393485172746 2.1348066523843942e-05 0.058394477179420055 0.019452248266258913 4.330635939534299e-11 10.363448324258378 -0.3810758527130772 VFYIGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFYIGLR 7 0 Q9GZP4-2;Q9GZP4;X6R8S9 Q9GZP4-2 PITHD1 PITH domain-containing protein 1 0 28835800.0 7291800.0 11233000.0 10311000.0 False True 9439378.842866661 10607873.675399408 8434503.79979428 1.0 1.1237893776681904 0.8935443677173986 23.17026049566972 -6.7606643746354775 1.609786718212532 1.0718458965716529 0.8926709100184088 0.6936948449232719 0.052071681839979164 0.2818286714741928 1.43953751312769 0.025519021217783076 0.061290533756530596 1.7351444096915772e-07 6.7606643746354775 -0.17917498655324404 VFYLK(ub)MK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFYLKMK 7 1 P61981;P27348;E9PG15;P31946;P31946-2;P63104;E7EX29;E7ESK7;B0AZS6;P63104-2;H0YB80;P31947-2;P31947;Q04917;A2IDB2 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta 1 219190000.0 34273000.0 85482000.0 99435000.0 True False 44932234.900204085 72728418.80622627 89146420.04787128 1.0 1.618624556907939 1.9840192735987492 25.421247486572625 -9.275387709364166 0.13352000964391295 4.8264135857897046e-18 2.701964470154852 0.999871455716721 0.004604637128341384 0.7285936038776182 0.049002096203118566 0.6129834903386512 0.3360869432974373 5.304107172300013e-10 9.275387709364166 2.701964470154852 VFYLK(ub)MK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFYLKMK 7 1 P61981;P27348;E9PG15;P31946;P31946-2;P63104;E7EX29;E7ESK7;B0AZS6;P63104-2;H0YB80;P31947-2;P31947;Q04917;A2IDB2 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta 1 273428000.0 55538000.0 67280000.0 150610000.0 True False 53774976.58996427 94145254.86056492 111160722.79684986 1.0 1.7507260966085614 2.0671459077416907 25.680431655806878 -10.315879347622106 0.19261477567521393 5.476757969230672e-21 2.358560559414476 0.9994418094288979 0.010573261116923843 1.964788840786751 0.0951600064546924 1.1710795964337966 0.20321131576338505 4.831930203917536e-11 10.315879347622106 2.358560559414476 VFYLK(ub)MK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VFYLKMK 7 1 P61981;P27348;E9PG15;P31946;P31946-2;P63104;E7EX29;E7ESK7;B0AZS6;P63104-2;H0YB80;P31947-2;P31947;Q04917;A2IDB2 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta 1 1704710000.0 143270000.0 733470000.0 827970000.0 True False 217351064.43999523 602576547.8727338 664321366.5878572 1.0 2.772365294944709 3.056444045026789 27.69545192008661 -10.220958626260101 0.4066822030410539 5.1414444948999126e-23 3.081398343368164 0.9991112060581996 0.027125943797178257 1.5875193385522541 0.18724161117530838 1.8585579983036207 0.07094466246867857 6.012310119633741e-11 10.220958626260101 3.081398343368164 VFYLK(ub)MK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFYLKMK 7 1 P61981;P27348;E9PG15;P31946;P31946-2;P63104;E7EX29;E7ESK7;B0AZS6;P63104-2;H0YB80;P31947-2;P31947;Q04917;A2IDB2 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta 1 251848000.0 34273000.0 40345000.0 177230000.0 True False 46944654.29299936 38562424.49692628 135371924.16642517 1.0 0.8214444238154059 2.8836493995997445 25.484457548095516 -6.88582018879537 1.0467514905543769 0.8778402895398186 3.0471727341270327 0.9780868019713773 0.1380980524055244 0.12260193711414923 0.2421626029826374 0.10103158689655319 0.24837577912949935 1.300707999476704e-07 6.88582018879537 2.169332444587214 up VFYLK(ub)MK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VFYLKMK 7 1 P61981;P27348;E9PG15;P31946;P31946-2;P63104;E7EX29;E7ESK7;B0AZS6;P63104-2;H0YB80;P31947-2;P31947;Q04917;A2IDB2 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta 1 308629000.0 55538000.0 77371000.0 175720000.0 True False 46182307.750568636 76954187.06605901 212462239.56251788 1.0 1.6663131578804977 4.600511535933409 25.460836931241154 -6.9426727599666345 0.6342101006150415 0.9679707632241137 5.458136684670526 0.9984934536428592 0.060708682338897965 0.08656816678000974 0.04921369618981412 0.06036900950814101 0.24971902604116628 1.1411092872964424e-07 6.9426727599666345 4.490165921446413 VFYLK(ub)MK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VFYLKMK 7 1 P61981;P27348;E9PG15;P31946;P31946-2;P63104;E7EX29;E7ESK7;B0AZS6;P63104-2;H0YB80;P31947-2;P31947;Q04917;A2IDB2 P61981;P27348;P31946;P31946-2;P63104;P31947-2;Q04917 YWHAG;YWHAQ;YWHAB;YWHAZ;SFN;YWHAH 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein theta;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed;14-3-3 protein zeta/delta;14-3-3 protein sigma;14-3-3 protein eta 1 1484960000.0 143270000.0 745560000.0 596130000.0 True False 185465839.27391124 704068930.6000874 487640456.8103358 1.0 3.796218933667134 2.629273718111227 27.46657824217906 -9.831665705004786 6.9203622546742105 0.9999999819765151 3.212746325889233 0.8274086587466853 0.4764033893158737 1.356298301674979e-07 2.1851157450874604e-08 0.4612755982241616 0.15375853274140072 1.4734462404806042e-10 9.831665705004786 2.212746343912718 VFYYLVQDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VFYYLVQDLK 10 0 P61326;Q96A72;F5H6P7;P61326-2 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 0 13160700.0 3660900.0 5386200.0 4113600.0 False True 4799475.352206027 4582599.955243158 3687964.1324375053 1.0 0.9548126865860068 0.7684098493687174 22.194445277628976 -6.944167672117446 0.6195803798054788 1.0020407178800748 0.7113136650235219 0.9986603801968014 0.0036686461352040075 0.08591575833570725 0.04633075319332526 0.0036960212801460885 0.015772835262830416 1.137188156231501e-07 6.944167672117446 -0.29072705285655287 VFYYLVQDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VFYYLVQDLK 10 0 P61326;Q96A72;F5H6P7;P61326-2 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 0 7403540.0 3979300.0 900440.0 2523800.0 False True 3852979.299658694 1259990.3877325684 1862741.067622931 1.0 0.32701717028279426 0.4834547301585391 21.877543004384712 -10.280689951225208 8.453692774959908 1.0000004937630014 0.4052359502239648 0.9506729600395782 0.06386536638361105 5.943313644140595e-07 5.046687498695573e-08 0.06183742669618361 0.020612458366930056 5.23974375568112e-11 10.280689951225208 -0.5947645435390365 VFYYLVQDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VFYYLVQDLK 10 0 P61326;Q96A72;F5H6P7;P61326-2 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 0 11240900.0 3660900.0 3409000.0 4171000.0 False True 5014433.66210257 3258379.107944514 3185895.7044414547 1.0 0.6498000227962462 0.6353450696774394 22.257655339151867 VGAEELTADQNLK(ub)FIDPFCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGAEELTADQNLKFIDPFCR 20 1 P56182 P56182 RRP1 Ribosomal RNA processing protein 1 homolog A 1 109659000.0 24209000.0 23908000.0 61542000.0 True False 36726822.91497072 19641430.60594342 49378196.725183174 1.0 0.5347979772553947 1.3444723176710027 25.130330764118213 -6.750875178050723 1.6464577738133535 0.7267490652860829 1.3462053462253545 0.6528043650461584 0.195490320305706 0.2985130587333121 1.5923717635443115 0.09378151405619066 0.2274805784669963 1.774699479581402e-07 6.750875178050723 0.6194562809392716 VGAEELTADQNLK(ub)FIDPFCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGAEELTADQNLKFIDPFCR 20 1 P56182 P56182 RRP1 Ribosomal RNA processing protein 1 homolog A 1 118402000.0 24209000.0 26462000.0 67731000.0 True False 31339027.730733063 24989366.438032493 55404652.97874763 1.0 0.7973880572410457 1.7679123122385276 24.901457086210662 -6.852214942650633 1.224317469545578 0.8916368581162304 1.8084080101417155 0.9434717641742426 0.09938678430091467 0.15503713743802539 0.44608450419664947 0.06348230882933643 0.14712836837700982 1.4053518100030806e-07 6.852214942650633 0.9167711520254851 VGAPLICCEIK(ub)LK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGAPLICCEIKLK 13 1 O60488-2;O60488;H0Y9A0 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 35003300.0 13025000.0 12924000.0 9054300.0 True False 17075901.134279422 10995789.577357441 8117447.890978454 1.0 0.6439361232470293 0.47537449573790813 24.025458379046192 -13.999999999984823 0.09944297559328004 2.7613461776889485 0.11323569457245432 0.9997965046950885 0.0031196413064256546 12.084671885003727 0.09379896991048683 4.37437701706229 0.3230839176554676 1.0000000000349469e-14 13.999999999984823 -2.6481104831164943 VGAPLICCEIK(ub)LK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGAPLICCEIKLK 13 1 O60488-2;O60488;H0Y9A0 O60488-2 ACSL4 Long-chain-fatty-acid--CoA ligase 4 1 33311800.0 13025000.0 9831800.0 10455000.0 True False 17840694.48738999 9397398.566585176 7985744.327483923 1.0 0.5267395040718491 0.44761398347627895 24.088668440569084 -13.999999999999998 0.25166831038844395 4.319179443189751 0.4162999573963712 0.9995458490255928 0.0051976168550258465 14.064760240234161 0.1587424226942508 23.62368840473195 0.0361804570819763 1.0000000000000041e-14 13.999999999999998 -3.9028794857933797 VGAPTIPDSCLPLGMSQEDNQLK(ub)LVPVTPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGAPTIPDSCLPLGMSQEDNQLKLVPVTPGR 31 1 Q92989;Q92989-2;E9PL17 Q92989 CLP1 Polyribonucleotide 5-hydroxyl-kinase Clp1 1 56280600.0 3716000.0 8933600.0 43631000.0 True False 5637443.675989544 7339329.281464616 35007313.725853354 1.0 1.301889598067929 6.2097850972690205 22.426609683718535 -6.919473805003618 0.8286296329605454 0.8896435577750856 6.991702615097759 0.9940333261641673 0.184454843717373 0.09848221829911011 0.10722895218189932 0.1584855701789282 0.4723709068136149 1.2037219915478928e-07 6.919473805003618 6.102059057322673 up VGASASDGSVCVLDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGASASDGSVCVLDLR 16 0 Q9BZK7;O60907;O60907-2;A0A0D9SFI2 Q9BZK7 TBL1XR1;TBL1X F-box-like/WD repeat-containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1X 0 11753400.0 2861100.0 4079400.0 4812900.0 False True 3750929.8069318146 3470769.421376659 4314907.276596769 1.0 0.9253090833538362 1.1503567111873727 21.838816834685886 -6.817252663468251 1.3837719441567835 0.9596267425785436 1.154984004918679 0.8779321619073762 0.0326987753721559 0.19707873239529616 0.7422523502806555 0.018572850737847837 0.042840869619804114 1.5231663495744146e-07 6.817252663468251 0.1953572623401354 VGASASDGSVCVLDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGASASDGSVCVLDLR 16 0 Q9BZK7;O60907;O60907-2;A0A0D9SFI2 Q9BZK7 TBL1XR1;TBL1X F-box-like/WD repeat-containing protein TBL1XR1;F-box-like/WD repeat-containing protein TBL1X 0 15113000.0 2861100.0 6176100.0 6075800.0 False True 3918925.988320271 5903219.480368469 4640821.175028867 1.0 1.506336046652084 1.1842074050033322 21.902026896208778 -10.185234134074351 4.681273863269536 0.9999470316231414 1.3452717258301303 0.6050241040670676 0.13150846727085685 7.271171042949365e-05 1.265546021369053e-05 0.12735201815459524 0.04244417530093219 6.527785359618093e-11 10.185234134074351 0.34532469420698897 VGAVDADKHHSLGGQYGVQGFPTIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGAVDADKHHSLGGQYGVQGFPTIK 25 1 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 36780400.0 8492100.0 10365000.0 17923300.0 False True 11133225.33761339 8818582.402453551 16068768.848433783 1.0 0.7920959232415908 1.4433165916570243 23.40836827167067 -6.820814415705151 1.368310075343714 0.888032238552735 1.4577878042954338 0.8862559938271882 0.09159576386446294 0.19242367530727608 0.7076816488042187 0.052600445849432874 0.12121220600279686 1.5107255849925467e-07 6.820814415705151 0.5697555657426987 VGAVDADKHHSLGGQYGVQGFPTIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGAVDADKHHSLGGQYGVQGFPTIK 25 1 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 34620100.0 8336000.0 6567700.0 19716400.0 False True 8071378.24289571 9190216.86010304 14552083.360678617 1.0 1.1386180381513047 1.8029242246808483 22.9443836138825 -6.9407564664152686 0.6524948864305707 0.9926296684743822 1.9861204890732065 0.9982612336366677 0.01461237278349634 0.08742333739553426 0.053052149545779026 0.014306879735709613 0.05698766239336364 1.1461554757549591e-07 6.9407564664152686 0.9934908205988243 VGAVDADKHHSLGGQYGVQGFPTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGAVDADKHHSLGGQYGVQGFPTIK 25 1 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 41888600.0 8492100.0 19320400.0 14076100.0 False True 11631858.860373486 18466760.843981 10751615.086379386 1.0 1.5876018670491376 0.9243247545761714 23.471578333193563 -6.672870032635002 1.9267901462694064 1.3741201228031152 0.9269424332565206 0.29203738317693384 0.24943389311094213 0.454536387139262 3.255854903479444 0.10410831212264572 0.27715588539695 2.1238799611706903e-07 6.672870032635002 -0.44717768954659465 VGAVDADKHHSLGGQYGVQGFPTIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGAVDADKHHSLGGQYGVQGFPTIK 25 1 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 15729100.0 8336000.0 5541500.0 1851600.0 False True 6931753.347415103 5511646.839598366 2238760.999168892 1.0 0.7951302597421035 0.3229718206871485 22.724788889316777 -6.957180359214019 0.47350121586525057 1.0120559925844343 0.08657534227356618 0.9996509077222328 0.005296628853180766 0.08072414846867987 0.024972742774549517 0.006572084850771375 0.03896094744246191 1.1036201995965618e-07 6.957180359214019 -0.9254806503108681 down VGAVDADKHHSLGGQYGVQGFPTIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGAVDADKHHSLGGQYGVQGFPTIK 25 1 Q15084-3;Q15084;Q15084-4;Q15084-5;Q15084-2 Q15084-3 PDIA6 Protein disulfide-isomerase A6 0 40679700.0 11870000.0 16786300.0 12023400.0 False True 15365948.992680455 15852127.6486564 9835264.570502058 1.0 1.0316400019424465 0.6400688024662239 23.873233533957603 -6.887326256482546 1.0380478831084652 1.0224077875773676 0.6081001099801487 0.9791318515950255 0.025655929600735088 0.12134023062014589 0.23472344170636353 0.018894536557260165 0.046673979244116225 1.2962051526432823e-07 6.887326256482546 -0.41430767759721887 VGCK(ub)YQAEIPDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGCKYQAEIPDR 12 1 O94776 O94776 MTA2 Metastasis-associated protein MTA2 1 13714600.0 5964800.0 5179300.0 2570500.0 True False 5775450.68896644 7247421.499692695 1897208.936652958 1.0 1.25486683031306 0.32849539175833176 22.461502101370908 -6.833342925293414 1.3128349821190457 1.1359009218235834 0.3018077141656529 0.912413913157323 0.11563676361915613 0.17671738813699103 0.59447288014994 0.06913196867632058 0.15910252044058124 1.467766849718798e-07 6.833342925293414 -0.8340932076579305 down VGCK(ub)YQAEIPDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGCKYQAEIPDR 12 1 O94776 O94776 MTA2 Metastasis-associated protein MTA2 1 48285000.0 14524000.0 18606000.0 15155000.0 True False 22033969.846628696 15285613.930658491 12159607.607327536 1.0 0.6937294567005711 0.5518573226688887 24.39322611213609 -13.999999999958213 0.10307821868299327 2.499833374973319 0.2636032890685878 0.9997782151573522 0.0027850586451229798 12.057681712589428 0.0962214661619151 3.8182984007773273 0.25666942885331345 1.0000000000962182e-14 13.999999999958213 -2.236230085904731 VGCK(ub)YQAEIPDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGCKYQAEIPDR 12 1 O94776 O94776 MTA2 Metastasis-associated protein MTA2 1 39761000.0 14524000.0 14781000.0 10456000.0 True False 18801604.31084169 13958424.356456745 8553115.287619935 1.0 0.7424060269371698 0.4549141204236437 24.16435243422854 -6.969705336442857 0.26513053962632055 1.0758217156512346 0.11291133019293341 0.9999799914292684 0.0009958815731760805 0.0763984427354711 0.00937177092367125 0.005808377614174033 0.026921922646917198 1.0722465648264846e-07 6.969705336442857 -0.9629103854583012 down VGDAIPAVEVFEGEPGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGDAIPAVEVFEGEPGNK 18 0 P30044-2;P30044;P30044-3 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 22387100.0 1528800.0 11639000.0 9219300.0 False True 2004271.6049202576 9902506.568466661 8265375.273770198 1.0 4.940700923047126 4.123879844168648 20.934646595083052 -10.08601750392214 5.790871109786743 0.9999819987954225 4.532290383608226 0.961441067015936 0.3334658090681867 7.749949776258768e-05 1.2231631250858958e-05 0.32287850764989995 0.10762562708738078 8.203184813258214e-11 10.08601750392214 3.5323083848128034 VGDAIPAVEVFEGEPGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGDAIPAVEVFEGEPGNK 18 0 P30044-2;P30044;P30044-3 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 22170500.0 7758000.0 3141500.0 11271000.0 False True 7511726.536514494 4395917.332706074 8318786.977247823 1.0 0.5852073170312478 1.107440072107286 22.8407131121354 -6.695085605717059 1.8485108250544213 0.7411978931067035 1.1057455614260097 0.3942491151099262 0.17525165930892217 0.40582982289273073 2.6924146771429505 0.07573806326102836 0.19596024267793646 2.0179685537183044e-07 6.695085605717059 0.3645476683193062 VGDAIPAVEVFEGEPGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGDAIPAVEVFEGEPGNK 18 0 P30044-2;P30044;P30044-3 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 23090800.0 1528800.0 10231000.0 11331000.0 False True 2094038.6742665481 9778960.590607325 8654851.169270232 1.0 4.66990448208053 4.133090413099297 20.997856656605943 -10.20070035057433 5.161714846995762 0.9997453678238252 4.401497447591655 0.9816628805866674 0.21915342596460916 0.0006422236108896653 9.944729967637573e-05 0.21220828889110305 0.07073146408456311 6.29940672043092e-11 10.20070035057433 3.4017520797678302 VGDALEEVLSK(ub)ALSQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGDALEEVLSKALSQR 16 1 A0A087WZQ0;P24522;A5JUZ3 A0A087WZQ0 GADD45A Growth arrest and DNA damage-inducible protein GADD45 alpha 1 29280400.0 1338000.0 2411400.0 25531000.0 True False 1295525.922384173 3374284.5952848727 18843665.186417714 1.0 2.604567409253482 14.545185751080515 20.305106452245454 -6.931468329647548 0.7346416411022187 0.8279490563947569 17.090766031300866 0.9968190010103213 0.3408088391367435 0.09188258751997204 0.07399801198459892 0.31324998177323826 1.0718300163271153 1.1709319878781675e-07 6.931468329647548 16.26281697490611 VGDALEEVLSK(ub)ALSQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGDALEEVLSKALSQR 16 1 A0A087WZQ0;P24522;A5JUZ3 A0A087WZQ0 GADD45A Growth arrest and DNA damage-inducible protein GADD45 alpha 1 26921000.0 1338000.0 3136000.0 22447000.0 True False 1112606.2834502652 3119105.745552739 27140563.91679849 1.0 2.803422730887504 24.393682042342796 20.08551172767973 -6.923427071374486 0.7988923497971762 0.5798617437360686 28.1654577981328 0.9950812660592808 0.7454052085675922 0.09619708034595036 0.09546943634426001 0.6541876405341848 2.0287051157363507 1.1928145516662144e-07 6.923427071374486 27.58559605439673 VGDDIAK(ub)ATGDWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGDDIAKATGDWK 13 1 P30050 P30050 RPL12 60S ribosomal protein L12 1 14666100.0 6745500.0 4166700.0 3753900.0 True False 8843415.82351492 3545044.6016693944 3365482.4379514675 1.0 0.4008682473397903 0.38056363119356484 23.07617229638313 VGDDIAK(ub)ATGDWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGDDIAKATGDWK 13 1 P30050 P30050 RPL12 60S ribosomal protein L12 1 15399260.0 5664060.0 4435200.0 5300000.0 True False 5484257.5156496875 6206198.48926245 3911771.0034081596 1.0 1.131638780920235 0.7132726704108378 22.38686488439249 -6.8221374657202825 1.3627546895813565 1.0708016385466879 0.7037250763554017 0.8891984443723199 0.05814058887845702 0.19071774200762073 0.6953818083607152 0.033522715677778286 0.07721803033989591 1.5061302605623985e-07 6.8221374657202825 -0.36707656219128615 VGDDIAK(ub)ATGDWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGDDIAKATGDWK 13 1 P30050 P30050 RPL12 60S ribosomal protein L12 1 16248700.0 4892600.0 5348000.0 6008100.0 True False 7422431.896971605 4393607.615885284 4820596.4015562255 1.0 0.5919363999389339 0.6494632040373529 22.82346052043916 -10.336756479085581 5.73385422541011 1.000059709220917 0.6206998019882461 0.9830407298661337 0.023485219429035285 1.7928883880255643e-05 2.073836570573022e-06 0.022743031543609203 0.007579821977555805 4.6051472452726284e-11 10.336756479085581 -0.37935990723267077 VGDDIAK(ub)ATGDWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGDDIAKATGDWK 13 1 P30050 P30050 RPL12 60S ribosomal protein L12 1 14432200.0 6745500.0 3734800.0 3951900.0 True False 9239493.640283238 3569784.1866679946 3018542.6119353147 1.0 0.38636145287270984 0.3267000042918781 23.139382357906022 -13.999999999999998 0.3295653882618154 7.66240184405651 0.3160801657397707 0.99971393911134 0.00514690429309839 18.78659922548876 0.1835517939828597 86.73674258697032 0.019149728039732767 1.0000000000000041e-14 13.999999999999998 -7.346321678316739 VGDDIAK(ub)ATGDWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGDDIAKATGDWK 13 1 P30050 P30050 RPL12 60S ribosomal protein L12 1 17574480.0 5664060.0 9097720.0 2812700.0 True False 4709916.85040306 9048708.776603965 3400822.56554458 1.0 1.9212035082593029 0.7220557546049986 22.167270159826767 -6.701448316104002 1.8254299935501137 1.5712000927696723 0.7254887593037117 0.42461079514468536 0.388747125898771 0.3925003979361273 2.543651931734165 0.16982211177554388 0.43600305713869275 1.9886194550926846e-07 6.701448316104002 -0.8457113334659606 VGDDIAK(ub)ATGDWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGDDIAKATGDWK 13 1 P30050 P30050 RPL12 60S ribosomal protein L12 1 16587800.0 4892600.0 5169000.0 6526200.0 True False 6333567.147564313 4881340.60608382 5338498.564466828 1.0 0.7707095373514792 0.8428897081354608 22.59458684253161 -10.240053139350493 7.509806641744074 1.0000003792748005 0.8067996227434701 0.9052360823086182 0.02946743132795018 1.8710564761410362e-07 1.8937258191233334e-08 0.028531773603998445 0.009510572565721813 5.7536953203589694e-11 10.240053139350493 -0.1932007565313304 VGDVYIPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGDVYIPR 8 0 J3QL05;J3KP15;Q01130-2;Q01130;Q9BRL6-2;Q9BRL6 J3QL05 SRSF2;SRSF8 Serine/arginine-rich splicing factor 2;Serine/arginine-rich splicing factor 8 0 18280980.0 546280.0 6981700.0 10753000.0 False True 716178.3701830459 5940057.574453441 9640382.710059442 1.0 8.294103566595066 13.460868285641586 19.449959421884866 -8.083429800601001 0.3672571561527815 1.5327635834126046e-16 15.482230682970087 0.9976463223926914 0.24799654639772026 0.10193162048843224 0.08902671243701947 0.877431366970972 1.3185488075555256 8.252208634732724e-09 8.083429800601001 15.482230682970087 VGDVYIPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGDVYIPR 8 0 J3QL05;J3KP15;Q01130-2;Q01130;Q9BRL6-2;Q9BRL6 J3QL05 SRSF2;SRSF8 Serine/arginine-rich splicing factor 2;Serine/arginine-rich splicing factor 8 0 6926500.0 6926500.0 0.0 0.0 False True 6706622.048874407 0.0 0.0 1.0 0.0 0.0 22.677154870709106 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 VGDVYIPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGDVYIPR 8 0 J3QL05;J3KP15;Q01130-2;Q01130;Q9BRL6-2;Q9BRL6 J3QL05 SRSF2;SRSF8 Serine/arginine-rich splicing factor 2;Serine/arginine-rich splicing factor 8 0 9356680.0 546280.0 8810400.0 0.0 False True 748254.4786619127 8421127.395903295 0.0 1.0 11.25436283517155 0.0 19.513169483407758 -6.6670871735402955 1.9485386563240177 7.562659944359539 0.04762756297475775 0.26547000080098104 4.358999225850837 0.46812125063212273 3.4239826201096 1.8030950329027204 4.834313310748404 2.1523496620643767e-07 6.6670871735402955 -7.515032381384781 VGEFSGANK(ub)EK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGEFSGANKEK 11 1 P10599;P10599-2 P10599 TXN Thioredoxin 1 6794300.0 2119100.0 3025200.0 1650000.0 True False 2778160.6213935907 2573851.952137238 1479273.8279176133 1.0 0.9264590147585251 0.5324651917265946 21.40569858152653 -6.938278335935247 0.6754006493157889 1.0045819823230906 0.431394590729789 0.9979294307361377 0.009340580329623118 0.08856126923579202 0.0582550634034966 0.008977775406439518 0.03417557602017623 1.15271425548923e-07 6.938278335935247 -0.5731873915933017 VGEFSGANK(ub)EK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGEFSGANKEK 11 1 P10599;P10599-2 P10599 TXN Thioredoxin 1 8647790.0 4576990.0 2872900.0 1197900.0 True False 4431695.957767659 4020063.951975586 884134.0537703092 1.0 0.9071163704110647 0.19950241672618413 22.079427476147373 -6.931019018159064 0.7383924502875874 1.010364749819755 0.05039637086676549 0.9967344685130213 0.020428254371316613 0.0921126654570206 0.07511694910669374 0.018725016860296366 0.06367217130084549 1.172144035147363e-07 6.931019018159064 -0.9599683789529895 down VGEFSGANK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGEFSGANKEK 11 1 P10599;P10599-2 P10599 TXN Thioredoxin 1 9602150.0 3411300.0 2478600.0 3712250.0 True False 5175191.49943573 2036274.4646098113 2978522.160363023 1.0 0.3934684281406463 0.5755385401077008 22.30318081747713 -10.383508560008798 5.145004583393172 1.0003470359368827 0.4845034841241485 0.9144451243141716 0.07432981195522902 0.0002960804698748133 3.5477277320386476e-05 0.07201674795303102 0.02398984365242773 4.135151638219328e-11 10.383508560008798 -0.5158435518127342 VGEFSGANK(ub)EK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGEFSGANKEK 11 1 P10599;P10599-2 P10599 TXN Thioredoxin 1 8791290.0 4576990.0 3152800.0 1061500.0 True False 3805969.9800366387 3135815.240618195 1283454.7421785374 1.0 0.8239201194613751 0.3372214570557864 21.85983275158165 -6.953276009318377 0.5216396281902913 1.0081667333673525 0.13119419705767205 0.9994339322199995 0.006669144731191179 0.08219631221934687 0.03071991659844014 0.007535720286093395 0.04020822492563687 1.113586585466642e-07 6.953276009318377 -0.8769725363096805 down VGEFSGANK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGEFSGANKEK 11 1 P10599;P10599-2 P10599 TXN Thioredoxin 1 9752560.0 3411300.0 3302160.0 3039100.0 True False 4415995.09677598 3118391.8931680676 2486014.983799323 1.0 0.7061583685735376 0.5629569166900361 22.07430713956958 -13.999999999994383 0.09448416964860966 2.47780799099349 0.23008810699059515 0.9998209801879779 0.0024340607132889197 12.12468556831674 0.09037803372311111 3.547467895792109 0.297963933919214 1.0000000000129332e-14 13.999999999994383 -2.2477198840028945 VGEQLEK(ub)MNGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGEQLEKMNGQR 12 1 J3KSB8;J3QRZ6;J3QLJ5;A9UHW6;A9UHW6-2;A9UHW6-3 J3KSB8 MIF4GD MIF4G domain-containing protein 1 3880810.0 937010.0 1776700.0 1167100.0 True False 1228429.1840177488 1511623.2855223562 1046339.6876137232 1.0 1.2305335180806936 0.8517704571227488 20.2283832615288 -6.741947327675148 1.679432007079699 1.1368541742036526 0.8514463375772309 0.6137238229863087 0.09685723791896426 0.31429722975834096 1.741297838713773 0.04560993872958815 0.11169017596246397 1.811559789814975e-07 6.741947327675148 -0.2854078366264218 VGEQLEK(ub)MNGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGEQLEKMNGQR 12 1 J3KSB8;J3QRZ6;J3QLJ5;A9UHW6;A9UHW6-2;A9UHW6-3 J3KSB8 MIF4GD MIF4G domain-containing protein 1 3454010.0 937010.0 1161700.0 1355300.0 True False 1283447.9187431333 1110372.2527718223 1035206.0532796715 1.0 0.8651478852832594 0.8065820499311243 20.291593323051693 -13.999999999979394 0.11354219667666374 1.647094894040192 0.7044233079759284 0.9997251190725923 0.0013426631463302919 11.992995540308138 0.10281206456997605 1.7680352918653588 0.0906756924741375 1.0000000000474465e-14 13.999999999979394 -0.9426715860642635 VGEQLEK(ub)MNGQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGEQLEKMNGQR 12 1 J3KSB8;J3QRZ6;J3QLJ5;A9UHW6;A9UHW6-2;A9UHW6-3 J3KSB8 MIF4GD MIF4G domain-containing protein 1 8682700.0 2413900.0 2870000.0 3398800.0 True False 3124841.1350826714 2710281.977067242 2780253.274632996 1.0 0.8673343251401925 0.8897262786959059 21.575351415273513 -10.553879769242425 9.194861919714702 1.0000096040415554 0.8785303019229153 0.97514695697071 0.00914147675926623 1.7999136490414144e-06 8.731988994234358e-08 0.008851896255816186 0.0029503989373650254 2.7933170404249956e-11 10.553879769242425 -0.12147930211864011 VGEVIVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGEVIVTK 8 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 62788500.0 4719500.0 35365000.0 22704000.0 False True 6187310.203703015 30088679.85169027 20354807.87214635 1.0 4.862966113074892 3.2897668295286526 22.560880935282395 -9.545723469032248 10.307305021425972 1.000000000002138 4.076366471387601 0.8360268214973118 0.6422559180667262 0.0 0.0 0.6218616186688964 0.20728720622296545 2.8462728552162137e-10 9.545723469032248 3.0763664713854633 VGEVIVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGEVIVTK 8 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 42377200.0 0.0 6037200.0 36340000.0 False True 0.0 8447885.443582093 26821463.82336846 0.0 VGEVIVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGEVIVTK 8 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 213407000.0 4619800.0 203670000.0 5117200.0 False True 7008574.352620165 167323497.21902692 4105783.1770515624 1.0 23.874113164893913 0.5858228750211675 22.740689577956665 -11.878457595961736 3.747314263760655e-20 8.575826986176136 13.638115455256532 0.0 11.192934425956565 0.0 0.8200886961220457 11.176440631844846 11.176440787204273 1.3229468727899486e-12 11.878457595961736 5.062288469080396 VGEVIVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGEVIVTK 8 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 62624500.0 4719500.0 27261000.0 30644000.0 False True 6464426.689691908 26056518.87992826 23406518.332990672 1.0 4.030754795545544 3.6208188995807484 22.624090996805286 -9.73635222022785 6.559935290098349 0.9999999854891883 3.825786847564454 0.9844613588488531 0.16735562873209564 3.5711845247048934e-08 5.889338308548248e-09 0.1620413907412819 0.0540137969137633 1.8350494832731346e-10 9.73635222022785 2.8257868620752657 VGEVIVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGEVIVTK 8 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 3617200.0 0.0 2105900.0 1511300.0 False True 0.0 2094555.0987115763 1827305.8425383184 0.0 VGEVIVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGEVIVTK 8 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 14879000.0 4619800.0 6516000.0 3743200.0 False True 5980422.169872382 6153378.871975658 3061976.008475409 1.0 1.0289204837368475 0.511999976172376 22.511815900049115 -6.8936540069505226 1.0004989266319013 1.0253909389683338 0.4642188892337756 0.9831364426330031 0.030797036430231562 0.11622912894096835 0.20492212007244656 0.023333875958967576 0.05899255914187128 1.277456125270995e-07 6.8936540069505226 -0.5611720497345583 VGEVIVTK(ub)DDAMLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGEVIVTKDDAMLLK 15 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 3780900.0 1378200.0 0.0 2402700.0 True False 1334449.7953885384 0.0 1773360.7905450556 1.0 0.0 1.3289078365280307 20.34781359881571 -6.705360056974478 1.8116031859593882 0.3823369233735216 1.325398828068923 0.44311926194650986 0.4217125767389686 0.3844731977897918 2.4566251395905203 0.18544930310108104 0.47382324456256364 1.9707881534060598e-07 6.705360056974478 0.9430619046954014 VGEVIVTK(ub)DDAMLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGEVIVTKDDAMLLK 15 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 87905700.0 2829200.0 9265500.0 75811000.0 True False 4292103.242225412 7611999.133318086 60826922.62085831 1.0 1.7734892903860675 14.1718218756826 22.033253348413766 -6.919636291397997 0.8274257106553642 0.7228366936192825 16.154495480411523 0.9940791778257874 0.464390566243741 0.09838618771633907 0.10672859048357371 0.3993512827224741 1.192108606345926 1.2032717167450952e-07 6.919636291397997 15.43165878679224 up VGEVIVTK(ub)DDAMLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGEVIVTKDDAMLLK 15 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 5686600.0 1378200.0 2110000.0 2198400.0 True False 1146034.3646122222 2098633.011197794 2658075.275746861 1.0 1.8312129862771593 2.3193678634988055 20.128218874249985 -9.016429958529148 0.15926987478274413 1.3935806253585529e-09 3.0753991145666855 0.9997995070708681 0.0077122135929459466 0.4910104034383796 0.052700416868851865 0.5834105308399772 0.3460590089454831 9.628752895570464e-10 9.016429958529148 3.0753991131731047 VGEVIVTK(ub)DDAMLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGEVIVTKDDAMLLK 15 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 68203300.0 2829200.0 3436900.0 61937200.0 True False 3662455.1718695466 3245633.4937220896 50665265.12933941 1.0 0.8861906402707763 13.83368881030609 21.804379670506215 -6.904918077545197 0.9296645128341009 0.5318912068460113 15.336997446023979 0.9888579462975843 0.6414487662593941 0.10787478261655935 0.15771197777274454 0.512309002831745 1.3690149637909255 1.244749390965744e-07 6.904918077545197 14.805106239177967 up VGEVTYVELLMDAEGK(ub)SR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGEVTYVELLMDAEGKSR 18 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 6853100.0 2599100.0 2714900.0 1539100.0 True False 3407445.269720203 2309847.5025973143 1379848.6960896945 1.0 0.6778824954646987 0.4049510958698388 21.70025905401794 -7.347801484876922 0.20551774924323493 1.1773815836611123 4.330258610113692e-16 0.999969553565095 0.001341946583601832 0.11349502273455155 0.014202419127429908 0.021487546616142838 0.05152897703515524 4.4895055742408464e-08 7.347801484876922 -1.177381583661112 down VGEVTYVELLMDAEGK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 2 VGEVTYVELLMDAEGKSR 18 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 32324500.0 7826900.0 13024600.0 11473000.0 True False 7578439.343728447 18225390.702391736 8467877.117377706 1.0 2.4049002539651116 1.1173642399586288 22.85346934873865 -6.625385298406588 2.0974134752775346 1.9286087495911766 1.122436842389976 0.1013128244014102 0.603320043250351 0.5708880386348313 4.779692372046094 0.2357773976500908 0.6684964263779376 2.369270797692929e-07 6.625385298406588 -0.8061719072012006 VGEVTYVELLMDAEGK(ub)SR ddPTM_RPMI8226_Bortezomib_8h_R1 2 VGEVTYVELLMDAEGKSR 18 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 81232800.0 11171300.0 21283500.0 48778000.0 True False 16947678.831426807 17485293.136255503 39137006.919843115 1.0 1.031722002179542 2.3092841980973633 24.014584358357688 -6.9122368719953196 0.8803554405155358 0.9631871575645103 2.4825428042299063 0.9917388361185837 0.05543102948814299 0.10295764890665336 0.13087831096310265 0.0458900817222107 0.12873083273531835 1.2239484537550093e-07 6.9122368719953196 1.519355646665396 up VGEVTYVELLMDAEGK(ub)SR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGEVTYVELLMDAEGKSR 18 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 7148300.0 2599100.0 2001100.0 2548100.0 True False 3560057.508036493 1912684.7852472176 1946291.2597667892 1.0 0.537262328186978 0.5467021966283468 21.763469115540833 -10.475525241073747 6.109447254276078 1.000286174821983 0.5419822624076625 0.9996815133825769 0.0038538101533927165 1.5031060725275884e-05 1.2903610802790578e-06 0.0037337061919264494 0.0012438118786279023 3.345605727213768e-11 10.475525241073747 -0.45830391241432045 VGEVTYVELLMDAEGK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VGEVTYVELLMDAEGKSR 18 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 30979800.0 7826900.0 12604600.0 10548300.0 True False 6508414.140461034 12536696.517982787 12753900.760171322 1.0 1.9262290701579001 1.95960190684299 22.633874624172925 -11.034059090348464 0.5729227939584624 9.103293360232015e-11 1.9561710242636725 0.9998948991728086 0.004559037327719808 2.958006353527699 0.28148419669456315 3.8860550804712677 0.006021786117695547 9.245723675498326e-12 11.034059090348464 1.9561710241726395 VGEVTYVELLMDAEGK(ub)SR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VGEVTYVELLMDAEGKSR 18 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 131588100.0 11171300.0 19992000.0 100424800.0 True False 14461468.069244396 18879427.62561959 82148516.84546421 1.0 1.3054986903972075 5.6805101980048445 23.785710680450137 -6.921000606165799 0.8172679590459826 0.9069061061732392 6.4025255237222405 0.9944544520327353 0.15921706665962815 0.09758663807768732 0.10258862354383319 0.13791361716886313 0.4171546818256877 1.1994976289513957e-07 6.921000606165799 5.495619417549001 up VGFQYEGTYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGFQYEGTYK 10 0 P11413;P11413-3;P11413-2 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 55124000.0 18492000.0 13295000.0 23337000.0 False True 24243191.076782744 11311437.823504113 20922311.104311105 1.0 0.46658205133468866 0.863018034137759 24.5310762742289 -9.755335401896861 6.051192415995908 1.0000000098536914 0.6648000427353111 0.48802914021886235 0.16184431226098342 2.1542867978156788e-08 4.244777609812796e-09 0.15670508618503062 0.05223502717161939 1.7565665087637254e-10 9.755335401896861 -0.3351999671183803 VGFQYEGTYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGFQYEGTYK 10 0 P11413;P11413-3;P11413-2 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 24059400.0 4694100.0 2294300.0 17071000.0 False True 4545088.364920431 3210425.9546164447 12599592.980977498 1.0 0.7063506134214947 2.772133778129102 22.11587691267496 -6.870870533445839 1.1294220377008788 0.8329994083683557 2.89516540756245 0.9655472649901251 0.16937594636182923 0.13602592550906858 0.32375636997123225 0.11631944130109306 0.2758271095326149 1.3462616252762705e-07 6.870870533445839 2.0621659991940944 up VGFQYEGTYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGFQYEGTYK 10 0 P11413;P11413-3;P11413-2 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 39516000.0 18492000.0 10857000.0 10167000.0 False True 25328992.127509855 10377301.840702137 7765763.995937732 1.0 0.4097005434902929 0.3065958549334983 24.594286335751793 -13.999999999999998 0.2454562374059929 5.0130938506086595 0.263309601982277 0.9995343592606628 0.006591983792960289 13.82244239626138 0.15678398771824065 27.27672370212833 0.0488150539979484 1.0000000000000041e-14 13.999999999999998 -4.749784248626383 VGFQYEGTYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGFQYEGTYK 10 0 P11413;P11413-3;P11413-2 P11413 G6PD Glucose-6-phosphate 1-dehydrogenase 0 16102900.0 4694100.0 6451200.0 4957600.0 False True 3903352.133889299 6416446.1051370585 5994211.238647501 1.0 1.6438296840884077 1.5356573101886328 21.896282188109236 -10.10263964594907 4.40528199583145 0.9999349117031385 1.5897434971682431 0.9753881008789381 0.044161186852890257 6641594.189708599 7615591.886942949 3392.096059562421 0.015117548611272163 7.895149426715198e-11 10.10263964594907 0.5898085854651046 VGGGWETFAGYLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGGGWETFAGYLLK 14 0 O43903 O43903 GAS2 Growth arrest-specific protein 2 0 1972680.0 511170.0 811470.0 650040.0 False True 670148.820177321 690401.8390852864 582780.0964239779 1.0 1.0302216736017031 0.8696278779835419 19.354121985366255 -6.8580306266254345 1.195621961342667 1.0163192071124767 0.8621377460580834 0.9512029544704755 0.015392856284733488 0.14884594145635976 0.40543866520732463 0.010048964212678726 0.023408090441218686 1.3866580377288147e-07 6.8580306266254345 -0.15418146105439334 VGGGWETFAGYLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGGGWETFAGYLLK 14 0 O43903 O43903 GAS2 Growth arrest-specific protein 2 0 2305200.0 2305200.0 0.0 0.0 False True 2232022.687802685 0.0 0.0 1.0 0.0 0.0 21.089920261103313 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 VGGGWETFAGYLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGGGWETFAGYLLK 14 0 O43903 O43903 GAS2 Growth arrest-specific protein 2 0 3584050.0 511170.0 787180.0 2285700.0 False True 700163.3628498376 752399.7847438431 1745864.7354691545 1.0 1.0746060486246958 2.4935105549697063 19.417332046889147 -6.917785571616066 0.8409847005613819 0.9661248936723215 2.7110614961906063 0.9935434040355738 0.055213576478388905 0.09949238126776434 0.11249438782934744 0.047022521196002816 0.13800681259412498 1.2084103278709687e-07 6.917785571616066 1.7449366025182849 up VGGIYTVLQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGGIYTVLQTK 11 0 P13807-2;P13807 P13807-2 GYS1 Glycogen [starch] synthase, muscle 0 4882800.0 1415100.0 1572900.0 1894800.0 False True 1855209.8038478945 1338229.4511161784 1698744.272205026 1.0 0.7213359094699445 0.9156615433368543 20.82315091835635 -10.074469238747048 5.2889649483216 1.000002310893468 0.8184987269179298 0.5377124542114597 0.07933310782026319 2.16181949546739e-06 3.783049517184179e-07 0.07681492994313827 0.025604650449115664 8.424240585603887e-11 10.074469238747048 -0.18150358397553812 VGGK(ub)ELLADQNLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGGKELLADQNLK 13 1 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 20761700.0 2923400.0 7014300.0 10824000.0 True False 4435011.529167881 5762543.362023965 8684631.655672273 1.0 1.2993299620813301 1.9581982140420109 22.08050642425676 -6.958128586675909 0.4610568376652366 0.9809965030313633 2.3031387970418877 0.9996943530935329 0.00699759145173901 0.0803766022191751 0.02365405564928033 0.008964353954436238 0.054422923741568895 1.1012132121186477e-07 6.958128586675909 1.3221422940105243 VGGK(ub)ELLADQNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGGKELLADQNLK 13 1 Q14684-2;Q14684 Q14684-2 RRP1B Ribosomal RNA processing protein 1 homolog B 1 6658500.0 2420300.0 2690300.0 1547900.0 True False 3315150.316148173 2571433.6503675976 1182317.9000011815 1.0 0.7756612536819478 0.35664081180333934 21.660642856085868 -6.961360110305775 0.41582427188387405 1.0193754742127332 0.09722788884092624 0.9998173573148337 0.003603356519686503 0.07921883309994882 0.019362447375828644 0.0054076645340012525 0.03492198000982751 1.0930496504454997e-07 6.961360110305775 -0.922147585371807 down VGGLLAFAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGGLLAFAKR 10 1 P28340;M0R2B7;A0A087WYJ2;M0QXE6;M0QXQ2;M0R3H8 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 5460400.0 1737500.0 1366800.0 2356100.0 True False 1682344.0135594173 1912570.3677678413 1738966.7285150904 1.0 1.1368485591251476 1.0336570371453777 20.682041314102225 -10.282640633544325 4.388459712446836 0.9999393843143533 1.085252798136069 0.4764550598275621 0.04212776244195228 2.5003295635213742e-05 4.087099142327618e-06 0.040819019238980944 0.013596676862087619 5.21626163536387e-11 10.282640633544325 0.08531341382171564 VGGSGVNVNAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGGSGVNVNAK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9020000.0 0.0 5152600.0 3867400.0 False True 0.0 4383852.16467749 3467238.5467203497 0.0 VGGSGVNVNAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGGSGVNVNAK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 10282300.0 0.0 5186300.0 5096000.0 False True 0.0 4957152.117199371 3892429.755414447 0.0 VGGSGVNVNAK(ub)GLDLGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGGSGVNVNAKGLDLGGR 18 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 23036000.0 5325700.0 6683300.0 11027000.0 True False 5156638.5686407965 9351976.54294909 8138697.897090917 1.0 1.8135799937233363 1.5782951992379295 22.29799949919271 -10.54153473477917 4.981489818224518 0.9963798193131987 1.6959375964806505 0.9210433922874011 0.09605461512087106 0.0038753312239933058 0.00035666100216821253 0.09332613275260655 0.031001493724115793 2.8738577339001942e-11 10.54153473477917 0.6995577771674517 VGGSGVNVNAK(ub)GLDLGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGGSGVNVNAKGLDLGGR 18 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 16641000.0 5325700.0 7488000.0 3827300.0 True False 4428555.518513509 7447660.657748373 4627570.734564214 1.0 1.6817358677369045 1.044939081201246 22.078404774626986 -10.276943606826066 4.381203177320749 0.9997537283842439 1.3633374744729283 0.302682815048412 0.2599711994919824 184132731.7442623 188.53737353349362 458556.59745357465 0.08899505641230257 5.2851387488953145e-11 10.276943606826066 0.3635837460886844 VGGTKPAGGDFGEVLNSAANASATTTEPLPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGGTKPAGGDFGEVLNSAANASATTTEPLPEK 32 1 P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;E5RK35 P55327-2 TPD52 Tumor protein D52 0 16870500.0 4047200.0 2123300.0 10700000.0 False True 3918723.8513252744 2971144.7628632234 7897349.0068806335 1.0 0.7581919205300499 2.0152859212597556 21.9019524805239 -6.856856179964361 1.2014523289258348 0.869740472509568 2.072622341341522 0.9497048517636579 0.12214109100993074 0.1500827263651624 0.4134545003050117 0.07938273060641106 0.18470359566117092 1.3904130011896584e-07 6.856856179964361 1.202881868831954 up VGGTKPAGGDFGEVLNSAANASATTTEPLPEK(ub)TQESL ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGGTKPAGGDFGEVLNSAANASATTTEPLPEKTQESL 37 2 P55327-2;P55327;P55327-3;P55327-4;P55327-7;P55327-5;P55327-6;E5RK35 P55327-2 TPD52 Tumor protein D52 1 14079200.0 5782700.0 4148400.0 4148100.0 True False 5599131.353789945 5804877.753620209 3061588.1696674344 1.0 1.0367461284313322 0.5467969897857645 22.4167715949258 -6.8888282089044806 1.0293156661027003 1.0270699345410321 0.5056157261058234 0.9801366679086705 0.03140206200472169 0.12009798679338031 0.22745540007764978 0.023280720391839798 0.057798305298216855 1.291730134010236e-07 6.8888282089044806 -0.5214542084352087 VGGTSDVEVNEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGGTSDVEVNEK 12 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 193077000.0 29786000.0 101140000.0 62151000.0 False True 39049734.448034264 86050306.24063222 55720210.71448943 1.0 2.2036079747262898 1.4269037037534669 25.218809401777083 -10.081703485696258 4.741520881875021 0.999966925975425 1.8152558392465075 0.59497405610345 0.3170881908702135 220320940.8470709 8.863798810131572 86768.20434773817 0.1085477217788228 8.285076337560114e-11 10.081703485696258 0.8152889132710824 VGGTSDVEVNEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGGTSDVEVNEK 12 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 160588000.0 53610000.0 12941000.0 94037000.0 False True 51908179.89463041 18108408.786423486 69405888.65047051 1.0 0.34885462798314554 1.3370896223169275 25.629458566254 -6.729000797382926 1.7268194647249389 0.6077002234147366 1.3363975370638552 0.5545919520497046 0.2737495586593703 0.3381444674310478 1.9749113385848285 0.12564909985550002 0.3121494645562781 1.8663762640862428e-07 6.729000797382926 0.7286973136491186 VGGTSDVEVNEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGGTSDVEVNEK 12 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 371172400.0 4798400.0 357340000.0 9034000.0 False True 7279523.6100291265 293569885.0898367 7248425.940257137 1.0 40.32817266852193 0.9957280625164611 22.79541260931726 -4.239851420728973 10.598560135305203 9.99999999996698 17.851101096053313 0.0 18.990128756248144 0.0 0.0 6.52488287780402 0.0 5.756368384649664e-05 4.239851420728973 7.851101096086333 VGGTSDVEVNEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGGTSDVEVNEK 12 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 169352000.0 29786000.0 57941000.0 81625000.0 False True 40798689.1363837 55380975.03473541 62346856.11964365 1.0 1.3574204516621942 1.528158316832871 25.282019463299974 -11.684314623265259 0.12464014787281481 2.952497123395405e-12 1.8226330110634177 0.9997485706064226 0.003489439711632634 4.766475529997747 0.08412962575350229 1.4983327762661534 0.2165482558772952 2.068642184529508e-12 11.684314623265259 1.8226330110604652 VGGTSDVEVNEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGGTSDVEVNEK 12 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 80733000.0 53610000.0 16854000.0 10269000.0 False True 44579090.32568662 16763204.15674292 12416200.421508623 1.0 0.3760328897309039 0.2785207219527844 25.409863841688278 -13.999999999999998 0.26127718616573703 5.598312511290519 0.24331425074422217 0.9995649512818476 0.006666441815625288 14.473961329906878 0.1617580938898771 35.16767064351126 0.04234613024444661 1.0000000000000041e-14 13.999999999999998 -5.354998260546297 VGGTSDVEVNEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGGTSDVEVNEK 12 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 63389400.0 4798400.0 36000000.0 22591000.0 False True 6211623.390604702 33996568.35345667 18479669.80323468 1.0 5.4730569153432045 2.975014523769395 22.56653893140971 -9.909564964759728 8.480437764942915 0.9999999981761354 4.2240357195563 0.6895326093655609 1.0198215358662677 3.860545614937857e-08 3.470097261752038e-09 0.98743795612843 0.32914598537614365 1.231501755443156e-10 9.909564964759728 3.2240357213801643 VGGTSDVEVNEK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGGTSDVEVNEKK 13 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 5059750.0 765640.0 3380400.0 913710.0 True False 1003761.4544683077 2876057.4966959963 819168.0541252128 1.0 2.8652798769000785 0.8160983373874683 19.936985020539076 -6.667142411812808 1.9472648861382043 2.1935431305743194 0.8244540716139349 0.266401220765346 0.7928629780262433 0.46781009738887247 3.4169598990269336 0.328094681020315 0.8799423875211339 2.1520759203488837e-07 6.667142411812808 -1.3690890589603844 VGGTSDVEVNEK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGGTSDVEVNEKK 13 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 5579040.0 1505800.0 1743240.0 2330000.0 True False 1457999.2032332462 2439324.8228765065 1719703.101498307 1.0 1.6730632070765754 1.179495227215974 20.475558500585898 -10.182832943823888 3.9968615528853597 0.9997724206103749 1.4262792171958232 0.4986375051028028 0.2014982843437705 142528419.95333192 278316886.42761576 422208.9981243868 0.07374081457504444 6.563977083862931e-11 10.182832943823888 0.4265067965854483 VGGTSDVEVNEK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGGTSDVEVNEKK 13 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 67710900.0 3109100.0 6642800.0 57959000.0 True False 4716732.005656382 5457340.439566706 46503378.24566785 1.0 1.1570172808254051 9.859236901715052 22.169356201759594 -6.9108103439589454 0.8901826313731814 0.7374171787758969 11.003626254314188 0.9912241382461408 0.3878119953124134 0.10388502783721533 0.1358728976664266 0.3187842877195425 0.8850268605759063 1.227975369912629e-07 6.9108103439589454 10.266209075538292 up VGGTSDVEVNEK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGGTSDVEVNEKK 13 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 5473200.0 1505800.0 2059700.0 1907700.0 True False 1252139.418250677 2048603.9872815604 2306591.2497917986 1.0 1.6360829772004128 1.8421201474627018 20.255963776020174 -11.04579586356526 0.216483001319381 5.47489464978907e-13 1.9796117461456106 0.9993168458234736 0.009368242358470367 3.1248101632033465 0.11916850139214706 1.6630801761444025 0.11500966556383764 8.999204821155389e-12 11.04579586356526 1.979611746145063 VGGTSDVEVNEK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGGTSDVEVNEKK 13 1 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 1 64534500.0 3109100.0 3955400.0 57470000.0 True False 4024791.2395234033 3735278.512923963 47011049.69199665 1.0 0.9280676414328205 11.68036971218499 21.940482523852044 -6.905393140359773 0.9265426770629437 0.6166709398100538 12.941224008063728 0.9890637460989192 0.5283013137985542 0.10754355326397903 0.15587745609367404 0.42290793712903546 1.133307003828748 1.2433885382044557e-07 6.905393140359773 12.324553068253675 up VGGVQSLGGTGALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGGVQSLGGTGALR 14 0 P17174;P17174-2 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 5927500.0 1353500.0 2350800.0 2223200.0 False True 1774451.6073126472 2000069.8033466313 1993164.590440263 1.0 1.127148125710611 1.1232566626366611 20.758941799207925 -10.130283834052012 4.247261408625293 0.9999746916729858 1.1252023941871558 0.999275975886157 0.0015886831931995436 1109176.593134268 0.013941314884862117 274.80622613479903 0.0005438485067788982 7.408259147513512e-11 10.130283834052012 0.12522770251417004 VGGVQSLGGTGALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGGVQSLGGTGALR 14 0 P17174;P17174-2 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 4607460.0 1476600.0 755760.0 2375100.0 False True 1429726.141249975 1057538.9092363354 1752990.058527307 1.0 0.7396793544753646 1.2261019841147411 20.447307399895944 -6.761324464550946 1.6073734710234666 0.8490386312687048 1.2280025051412826 0.6963689077160162 0.10951388262279659 0.28071086003747886 1.429687169458649 0.05374779129692407 0.12900178858298011 1.7325091439953086e-07 6.761324464550946 0.3789638738725778 VGGVQSLGGTGALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGGVQSLGGTGALR 14 0 P17174;P17174-2 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 7109600.0 1353500.0 1874400.0 3881700.0 False True 1853925.5269621792 1791582.8101880893 2964922.4061209327 1.0 0.9663725883982816 1.599267264515862 20.822151860730816 -6.894356828795053 0.9962459748489074 0.9694583582747955 1.6585866589301528 0.9835431228189998 0.037298375070511064 0.11568094458343813 0.20176728852998946 0.028350223288652773 0.07188166578388881 1.275390480825012e-07 6.894356828795053 0.6891283006553572 VGIALKPFLPQLQTTFTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGIALKPFLPQLQTTFTK 18 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 10198100.0 4344000.0 3672000.0 2182100.0 False True 5695026.067355834 3124151.913343892 1956317.2241812262 1.0 0.5485755247463541 0.3435133046001197 22.44127101479732 -12.655316915400961 0.12125376210484659 2.5867418790220196 2.6291052501670893e-23 0.9997309194143267 0.0044983448433469995 7.314437058188197 0.09349054860231977 3.112613956517356 0.27625894644157806 2.2114803488723715e-13 12.655316915400961 -2.5867418790220196 VGIALKPFLPQLQTTFTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGIALKPFLPQLQTTFTK 18 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 15499800.0 6504900.0 3516000.0 5478900.0 False True 6298405.510102243 4919957.135697779 4043811.7265232047 1.0 0.7811432794866066 0.6420373727981132 22.586555214790547 -9.688640483783608 0.07015507781314229 1.8089697608310369 1.2249254576572304e-09 0.9999845367383204 0.0005793678768472852 1.2053216958893818 0.029773770034246052 0.470034631305586 0.29825993718685334 2.0481394191185683e-10 9.688640483783608 -1.8089697596061114 VGIALKPFLPQLQTTFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGIALKPFLPQLQTTFTK 18 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 23260400.0 6458300.0 8924300.0 7877800.0 False True 9797713.264973974 7331688.939125853 6320749.377037599 1.0 0.7483061343850552 0.6451249598856666 23.224013640363882 -13.999999999999998 0.1225851557693864 2.1976951918793737 0.4860349999206565 0.9996803560001833 0.002664726552167959 11.954562884863122 0.10807793742544497 3.4767283426956377 0.14121247770649525 1.0000000000000041e-14 13.999999999999998 -1.711660191958717 VGIALKPFLPQLQTTFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGIALKPFLPQLQTTFTK 18 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 20255100.0 4344000.0 3857100.0 12054000.0 False True 5950094.192185953 3686680.568275974 9207093.459922642 1.0 0.6196003708844745 1.5473861694515676 22.50448107632021 -6.79537379307745 1.4746273719831993 0.7888635408869906 1.5587887295947545 0.8182884600537172 0.16232879026855587 0.22744788204258745 0.9768372728603956 0.08661849227987986 0.20204547876590717 1.6018660864868031e-07 6.79537379307745 0.7699251887077638 VGIALKPFLPQLQTTFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGIALKPFLPQLQTTFTK 18 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 15950100.0 6504900.0 2751100.0 6694100.0 False True 5409112.565930961 2736279.2782494025 8093805.35997865 1.0 0.505864731949512 1.496327773054142 22.366960490224823 -6.771093065603983 1.5706233831994054 0.7169694106938891 1.5020833864455727 0.7345997167568983 0.20831171525937403 0.26466505656144007 1.2887115452372107 0.10454032234069395 0.24856471818743062 1.6939747572052486e-07 6.771093065603983 0.7851139757516836 VGIEEK(ub)K(ub)APK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGIEEKKAPK 10 2 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 2 2854070.0 709270.0 0.0 2144800.0 True False 1076014.4445826449 0.0 1720879.339900765 1.0 0.0 1.5993087718894377 20.037266014307814 -6.737622051928002 1.6955483093172403 0.40341361991824143 1.5997593478994645 0.5943370517046247 0.42018056436114737 0.3220450452163456 1.816983878770187 0.19612966639757606 0.4825194953030677 1.829691826698156e-07 6.737622051928002 1.196345727981223 VGIEEK(ub)K(ub)APK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGIEEKKAPK 10 2 O95155-3;O95155-2;O95155;O95155-4 O95155-3 UBE4B Ubiquitin conjugation factor E4 B 2 2746190.0 709270.0 728620.0 1308300.0 True False 918163.9968018924 688071.6564915451 1070202.8242916164 1.0 0.7493995178292826 1.1655900558280425 19.808392336400264 -6.7436416902309695 1.673109820296172 0.8515276057075292 1.1660454218107752 0.6212743814515397 0.10528779134976496 0.3112714201458758 1.7121632977022685 0.049753493263826803 0.12161796234218188 1.8045059141476692e-07 6.7436416902309695 0.31451781610324603 VGILAIQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGILAIQLK 9 0 Q7Z392;D6RHE5;Q7Z392-4;Q7Z392-3 Q7Z392 TRAPPC11 Trafficking protein particle complex subunit 11 0 2525760.0 779580.0 820800.0 925380.0 False True 1022036.9294634595 698339.8394533409 829630.5544717573 1.0 0.6832823935432054 0.8117422478141664 19.963015895728116 -10.081054919798634 4.928889704556533 1.000007462103129 0.747512320982202 0.8374225244850075 0.052443515905056956 4.300460927216247e-06 8.018518596361448e-07 0.0507797160311455 0.016926071975590425 8.297458332879867e-11 10.081054919798634 -0.25249514112092697 VGILAIQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGILAIQLK 9 0 Q7Z392;D6RHE5;Q7Z392-4;Q7Z392-3 Q7Z392 TRAPPC11 Trafficking protein particle complex subunit 11 0 3623480.0 779580.0 1060200.0 1783700.0 False True 1067811.793357351 1013356.8583874379 1362426.7964546217 1.0 0.9490032463504648 1.275905365467972 20.026225957251008 -6.867046916735706 1.1496791772012678 0.9716169194689585 1.2939997742913227 0.9616418699128677 0.02812445239832082 0.13971365141760445 0.3470062917141406 0.019018020191962446 0.044806694307816454 1.3581667162152104e-07 6.867046916735706 0.3223828548223643 VGINYQPPTVVPGGDLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGINYQPPTVVPGGDLAK 18 0 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 383124000.0 69434000.0 148690000.0 165000000.0 False True 91028646.3998126 126506031.58908057 147927382.7917612 1.0 1.3897386876812992 1.6250640720509026 26.439817292109403 -9.784015162036688 0.097724790856035 1.3380760521068658e-15 2.315584918061707 0.9999420575354504 0.001962087855557229 1.327816386124149 0.04316295613618894 0.6823174553479934 0.3482208964574178 1.6443143161093192e-10 9.784015162036688 2.3155849180617056 VGINYQPPTVVPGGDLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGINYQPPTVVPGGDLAK 18 0 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 258888000.0 65077000.0 32331000.0 161480000.0 False True 63011166.25634878 45240936.90393768 119183543.70383975 1.0 0.7179828527515846 1.8914670333027084 25.909104176557214 -6.843259460451704 1.2672346500363696 0.8499815850349374 1.9326062741263415 0.9299044370961271 0.13241643075094453 0.16502681445063205 0.5133869574282264 0.08188984184837761 0.18884925755017576 1.434632085362175e-07 6.843259460451704 1.082624689091404 VGINYQPPTVVPGGDLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGINYQPPTVVPGGDLAK 18 0 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 831252000.0 21533000.0 786400000.0 23319000.0 False True 32667135.273165513 646060775.8287553 18709989.428919207 1.0 19.777086984406107 0.5727465623313645 24.96133660816995 -6.48245242026707 2.7056740852803425 9.999999999999998 0.5325786749415444 0.2650545557653887 7.676177325085393 0.605219671698 8.276394220621956 2.9773883453077277 10.370709033883598 3.2926652460718453e-07 6.48245242026707 -9.467421325058453 VGINYQPPTVVPGGDLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGINYQPPTVVPGGDLAK 18 0 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 385384000.0 69434000.0 155170000.0 160780000.0 False True 95105626.1832966 148314076.3214286 122807075.36804055 1.0 1.5594669029946095 1.2912703516756734 26.503027353632294 -10.035148470013999 4.409258793782181 0.9999769611328321 1.4253686273250226 0.7703262218844331 0.10949078376948988 25241891.745968238 0.8447836033787953 6069.996957349182 0.03748160754093419 9.222560863255592e-11 10.035148470013999 0.4253916661921905 VGINYQPPTVVPGGDLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGINYQPPTVVPGGDLAK 18 0 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 123353000.0 65077000.0 21386000.0 36890000.0 False True 54114408.89991987 21270789.373211373 44603528.43991167 1.0 0.39307071454018727 0.8242449533617232 25.68950945199149 -9.886905862511629 6.996165384982824 1.0000000063850745 0.6086578339509524 0.5234383309454542 0.1760261458909595 1.7467528304090115e-08 2.904108676005351e-09 0.1704365854228876 0.056812194294395456 1.297460477490567e-10 9.886905862511629 -0.39134217243412206 VGINYQPPTVVPGGDLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGINYQPPTVVPGGDLAK 18 0 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 0 82089000.0 21533000.0 35030000.0 25526000.0 False True 27874892.97888697 33080549.706155185 20880529.918877818 1.0 1.186750734118014 0.7490801824671819 24.7324629302624 -6.790751003679526 1.4932054542664221 1.1042728967711795 0.7443200671106409 0.8037885249781166 0.07942994901753168 0.23423201011328548 1.0317020464144926 0.04186719307432897 0.09797331774032496 1.6190080059035433e-07 6.790751003679526 -0.35995282966053854 VGINYQPPTVVPGGDLAK(ub)VQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGINYQPPTVVPGGDLAKVQR 21 1 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 1485646200.0 467491400.0 601461900.0 416692900.0 True False 612885752.5931579 511726129.000123 373577515.9085396 1.0 0.834945382291851 0.6095385874576295 29.191042926769143 -6.966769645370056 0.3262564907765407 1.0286884480575933 0.408457566651391 0.9999451123925776 0.0011856511247612812 0.07736547611419373 0.012769453724322921 0.003334356730331058 0.019720950523668356 1.0795191593876418e-07 6.966769645370056 -0.6202308814062023 VGINYQPPTVVPGGDLAK(ub)VQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGINYQPPTVVPGGDLAKVQR 21 1 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 1492496900.0 455843300.0 488254900.0 548398700.0 True False 441372803.9575074 683217627.785667 404756628.8616481 1.0 1.5479377561546426 0.9170402553860467 28.717422496998257 -6.677078415546821 1.9122668028002443 1.347593787743953 0.9194939857348727 0.310783204569961 0.2323792537150163 0.445059220998848 3.143971239415464 0.09760056447682675 0.25838252154712404 2.1033986190428776e-07 6.677078415546821 -0.42809980200908027 VGINYQPPTVVPGGDLAK(ub)VQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGINYQPPTVVPGGDLAKVQR 21 1 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 3955723000.0 1358278000.0 792368000.0 1805077000.0 True False 2060607029.422965 650963739.6005594 1448302739.756647 1.0 0.3159087251016754 0.7028524697220981 30.94042225417714 -10.743913973195736 6.952875654693343 1.00813224432381 0.5093805974124918 0.6818877595865276 0.15796912224697318 0.019906062492457032 0.0007331725812602997 0.1528953414788752 0.05098431497312756 1.8033749252677292e-11 10.743913973195736 -0.49875164691131835 VGINYQPPTVVPGGDLAK(ub)VQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGINYQPPTVVPGGDLAKVQR 21 1 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 1387170500.0 467491400.0 499113200.0 420565900.0 True False 640335604.0600564 477060728.4773642 321236896.24659675 1.0 0.7450167153794889 0.5016695842145742 29.254252988292034 -6.971692765068689 0.21392328887962145 1.12119904838745 0.1186636789383036 0.9999927471063993 0.0005479144778013536 0.07575715334039282 0.0070301195566250755 0.007065187633666306 0.024992735910456216 1.0673509351609747e-07 6.971692765068689 -1.0025353694491466 VGINYQPPTVVPGGDLAK(ub)VQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGINYQPPTVVPGGDLAKVQR 21 1 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 1515046200.0 455843300.0 604519700.0 454683200.0 True False 379053901.2322152 601263032.3883339 549755354.9024142 1.0 1.5862204041002321 1.4503355673567495 28.497827772432533 -10.05219889874406 4.573931094723317 0.9999768341541198 1.5182779856306328 0.9509718613485181 0.055474752389230095 38432464.219246686 0.34145332933797945 9695.849522271239 0.01899048327146716 8.867498042141602e-11 10.05219889874406 0.518301151476513 VGINYQPPTVVPGGDLAK(ub)VQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGINYQPPTVVPGGDLAKVQR 21 1 P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;P0DPH8;P0DPH7;P0DPH7-2;Q6PEY2;Q9BQE3;F5H5D3;A0A1W2PQM2 P68363;P68366-2;Q71U36;Q9BQE3 TUBA1B;TUBA4A;TUBA1A;TUBA3E;TUBA1C Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-3E chain;Tubulin alpha-1C chain 1 3584516000.0 1358278000.0 832211000.0 1394027000.0 True False 1758317646.662176 785897726.2777374 1140328389.9249175 1.0 0.4469600403372004 0.6485337800536832 30.71154857626959 -10.097374420672562 5.146797108411611 1.000010227060403 0.5477469101945935 0.8703272637714273 0.0822921346446236 9.657363096731598e-06 1.6935650463082063e-06 0.07968081671651263 0.02655967224978152 7.99144986698362e-11 10.097374420672562 -0.45226331686580945 VGIVAWHPTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGIVAWHPTAR 11 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;F8W1H8;F8VUX3;F8VSA4;F8VRE9;F8VTT6;F8VVB7;F8VV53 Q9ULV4 CORO1C Coronin-1C;Coronin 0 68887000.0 14735000.0 15544000.0 38608000.0 False True 19317727.69394298 13224895.790037442 34613214.514086746 1.0 0.6845989341792033 1.7917849895430313 24.203422067004322 -6.8305732855742605 1.3253236182084518 0.8315381031300051 1.8219348259878554 0.9070260615005447 0.14201311023965865 0.18010023682221263 0.6184789232800517 0.08412761900319198 0.19360085974383698 1.4771571957889708e-07 6.8305732855742605 0.9903967228578503 VGIVAWHPTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGIVAWHPTAR 11 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;F8W1H8;F8VUX3;F8VSA4;F8VRE9;F8VTT6;F8VVB7;F8VV53 Q9ULV4 CORO1C Coronin-1C;Coronin 0 56699700.0 10149000.0 4687700.0 41863000.0 False True 9826825.550281733 6559523.056032565 30897824.43691999 1.0 0.6675119063087983 3.1442325172887755 23.228294014119136 -6.87305046073565 1.1178921958541461 0.80801840720116 3.2979066069509395 0.9676310689064995 0.19747229142214845 0.1339606427205441 0.31104300827607256 0.1368273242527517 0.3257586752694023 1.3395210392497314e-07 6.87305046073565 2.4898881997497795 up VGIVAWHPTAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGIVAWHPTAR 11 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;F8W1H8;F8VUX3;F8VSA4;F8VRE9;F8VTT6;F8VVB7;F8VV53 Q9ULV4 CORO1C Coronin-1C;Coronin 0 42688300.0 7668300.0 24690000.0 10330000.0 False True 11633371.727823101 20283876.59614951 8288270.972200158 1.0 1.7435939528724351 0.7124564714439073 23.47176596136788 -6.713189912569109 1.7836001473400027 1.4556405639435026 0.7146179411597864 0.4803468799627517 0.313194425200493 0.368698214933286 2.2882542580410314 0.1396292318196313 0.3533895442353858 1.9355753713919457e-07 6.713189912569109 -0.7410226227837162 VGIVAWHPTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGIVAWHPTAR 11 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;F8W1H8;F8VUX3;F8VSA4;F8VRE9;F8VTT6;F8VVB7;F8VV53 Q9ULV4 CORO1C Coronin-1C;Coronin 0 58724000.0 14735000.0 13444000.0 30545000.0 False True 20182927.69840242 12849999.626637146 23330900.094021644 1.0 0.63667669124407 1.1559720394711814 24.266632128527213 -6.718631428843554 1.7643003566148514 0.7786330240900577 1.155096725005832 0.5059956162693973 0.15291437545001563 0.3579976985345918 2.1770891484807655 0.06883903227042609 0.17308655574586146 1.9114747749181798e-07 6.718631428843554 0.3764637009157742 VGIVAWHPTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGIVAWHPTAR 11 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;F8W1H8;F8VUX3;F8VSA4;F8VRE9;F8VTT6;F8VVB7;F8VV53 Q9ULV4 CORO1C Coronin-1C;Coronin 0 18452400.0 10149000.0 8303400.0 0.0 False True 8439343.176933281 8258667.936104142 0.0 1.0 0.9785913148640564 0.0 23.008699289553412 -7.040530928292639 1.0636761222476476 1.0155881846062205 8.115856169229694e-19 0.9872652367692034 0.05263704925316901 0.08597720854735694 0.18787170338466266 0.04157465880114232 0.07474536538822589 9.108965804327387e-08 7.040530928292639 -1.0155881846062205 down VGIVAWHPTAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGIVAWHPTAR 11 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;B4E3S0;F8W1H8;F8VUX3;F8VSA4;F8VRE9;F8VTT6;F8VVB7;F8VV53 Q9ULV4 CORO1C Coronin-1C;Coronin 0 33439300.0 7668300.0 10166000.0 15605000.0 False True 9926765.51479119 9600253.16336779 12765050.120821424 1.0 0.9671078811182869 1.2859223985699169 23.24289228346033 -6.881445153242016 1.0716706911331728 0.9791951109756605 1.3091554968143322 0.9748340617408028 0.02271200494770596 0.12635927607512326 0.26459653749221285 0.01630329281067244 0.039575552705943644 1.3138774131777013e-07 6.881445153242016 0.3299603858386717 VGK(ub)ELTEKPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGKELTEKPK 10 2 Q9BVK2-2;Q9BVK2;E9PKA5;E9PK79;E9PP96;H0YEE0;E9PR58;E9PNE2 Q9BVK2-2 ALG8 Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase 1 5184430.0 546630.0 2268800.0 2369000.0 True False 829277.674005966 1863914.9137846897 1900766.1116304132 1.0 2.247636674915814 2.292074381369079 19.661495726744032 -10.817124031381619 0.5984596668104871 1.1188458200282053e-17 2.286795763103303 0.999890656974966 0.006262428239999598 2.475461437707852 0.2943947820398137 3.540438583008953 0.007739675439221476 1.5236175574356024e-11 10.817124031381619 2.286795763103303 VGK(ub)ELTEKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGKELTEKPK 10 2 Q9BVK2-2;Q9BVK2;E9PKA5;E9PK79;E9PP96;H0YEE0;E9PR58;E9PNE2 Q9BVK2-2 ALG8 Probable dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase 1 3402830.0 546630.0 1211600.0 1644600.0 True False 707623.3106881988 1144173.3949180034 1345299.6750210163 1.0 1.6169243969722225 1.9011522863946435 19.432622048836482 -10.435752442130749 0.1653764066862159 3.6417198872551573e-16 2.2425076879131898 0.9996005009437616 0.007518454548258285 2.1947806073467135 0.08514665982033534 1.1282588072722313 0.22641462308734103 3.6664651205912366e-11 10.435752442130749 2.2425076879131893 VGK(ub)NNFRPPPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGKNNFRPPPK 11 2 Q9UNQ2;A0A494C0G7;A0A0C4DGB1 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 1 2015530.0 422590.0 376240.0 1216700.0 True False 409175.1117640711 526474.5940656802 898009.7697823988 1.0 1.286673062288411 2.194683263874045 18.642358869699596 -6.950224052654304 0.5563804455185561 0.9878917345383544 2.5365909467010788 0.9992187351377998 0.014233836129678004 0.08339594727178634 0.03559128935456828 0.015325436105256631 0.07542227647163624 1.1214397539313941e-07 6.950224052654304 1.5486992121627243 up VGK(ub)NNFRPPPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGKNNFRPPPK 11 2 Q9UNQ2;A0A494C0G7;A0A0C4DGB1 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 1 1630610.0 422590.0 634270.0 573750.0 True False 351402.308911246 630853.0616172628 693718.4722797315 1.0 1.7952444978857491 1.9741431820100663 18.422764145133872 -10.949609849563199 0.2857236123913477 4.587933608770186e-13 2.0357996772271267 0.999215572542258 0.011858303069131224 2.8143861115337607 0.14703151448762775 1.935485089355302 0.06851419701290806 1.1230268776120386e-11 10.949609849563199 2.035799677226668 VGK(ub)NNFRPPPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGKNNFRPPPK 11 2 Q9UNQ2;A0A494C0G7;A0A0C4DGB1 Q9UNQ2 DIMT1 Probable dimethyladenosine transferase 1 4624740.0 522800.0 668640.0 3433300.0 True False 676774.9059286715 631429.5962182018 2808474.6286328863 1.0 0.9329979446441697 4.149791317659885 19.368316550336402 -6.902143665984815 0.9476084009267812 0.8740098997202321 4.502551097144214 0.9876031832773358 0.16710809812442418 0.10984477189279233 0.16865086210911867 0.13170792424134742 0.3465213721954134 1.252726700445592e-07 6.902143665984815 3.628541197423982 up VGK(ub)TYELLNCDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGKTYELLNCDK 12 1 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 1 9010900.0 3577900.0 4163600.0 1269400.0 True False 4690661.548432882 3542407.1095856824 1138054.6649446154 1.0 0.7552041589462315 0.2426213558991123 22.161359977211387 -7.032526147915029 0.4686836740589591 1.0138823760832323 8.437190266595056e-12 0.9996980802369108 0.005483378166487472 0.0737123439585654 0.023910336262978265 0.007057017542272756 0.03878680185322696 9.278416251431901e-08 7.032526147915029 -1.013882376074795 down VGK(ub)TYELLNCDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGKTYELLNCDK 12 1 Q92979;V9GYP5;A0A087WWQ2;A0A087WVM7 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 1 10302300.0 3577900.0 5478700.0 1245700.0 True False 4900746.319111907 5236632.91836187 951491.3159968168 1.0 1.068537846560242 0.19415232987804237 22.224570038734278 -6.887956068149882 1.034425625902492 1.0493097895796761 0.12189858433291362 0.9795564610979534 0.05676655855462456 0.12081602748531567 0.23167412649885671 0.04192259247873059 0.10377083595649068 1.2943267648116756e-07 6.887956068149882 -0.9274112052467625 down VGLEHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGLEHLR 7 0 E7ENL6;P12111-4;P12111-2;P12111 E7ENL6 COL6A3 Collagen alpha-3(VI) chain 0 72925000.0 25579000.0 25124000.0 22222000.0 False True 33534316.707388386 21375597.132584963 19922680.608475875 1.0 0.6374245618034443 0.5940983018176854 24.999134870322504 -13.999999999999998 0.2997228425639598 4.302035574634385 0.583407215027746 0.9996492119813208 0.0034086101697592083 16.570433738263425 0.17386025338271807 33.92725049416321 0.01567652016425427 1.0000000000000041e-14 13.999999999999998 -3.7186283596066385 VGLEHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGLEHLR 7 0 E7ENL6;P12111-4;P12111-2;P12111 E7ENL6 COL6A3 Collagen alpha-3(VI) chain 0 97831000.0 39920000.0 24500000.0 33411000.0 False True 38652761.45110325 34282977.76581214 24659656.79148492 1.0 0.8869476973639 0.6379791731744711 25.204068151828615 -6.958118472677051 0.4611924495189839 1.007171219027073 0.5076992683902443 0.9996939030497111 0.002645796975995334 0.08038031164318385 0.023668086184073178 0.0033881781409019276 0.0205646592760327 1.1012388578482708e-07 6.958118472677051 -0.4994719506368287 VGLEHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGLEHLR 7 0 E7ENL6;P12111-4;P12111-2;P12111 E7ENL6 COL6A3 Collagen alpha-3(VI) chain 0 149692000.0 46991000.0 57781000.0 44920000.0 False True 71288782.50226727 47469529.10498643 36041542.310864575 1.0 0.6658765578368057 0.5055710175681329 26.087171746469224 -13.9999999997327 0.09717261018537114 2.664694981260043 0.14866249503551093 0.9998077936818869 0.0028554698501985277 12.102553983945787 0.09224958250283524 4.070600426066455 0.31887292154738733 1.000000000615483e-14 13.9999999997327 -2.516032486224532 VGLEHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGLEHLR 7 0 E7ENL6;P12111-4;P12111-2;P12111 E7ENL6 COL6A3 Collagen alpha-3(VI) chain 0 155161000.0 25579000.0 46922000.0 82660000.0 False True 35036247.546483606 44848830.8896957 63137410.43613786 1.0 1.2800694717718686 1.8020597197908146 25.062344931845395 -6.961400534022804 0.41522404032468796 0.9757058095843844 2.125960795024973 0.9998186670836338 0.004475652108723535 0.07920456447718689 0.0193103877475594 0.006734609602606638 0.043511473143257595 1.0929479151591489e-07 6.961400534022804 1.1502549854405886 VGLEHLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGLEHLR 7 0 E7ENL6;P12111-4;P12111-2;P12111 E7ENL6 COL6A3 Collagen alpha-3(VI) chain 0 69114000.0 39920000.0 14433000.0 14761000.0 False True 33195248.755855426 14355246.56427382 17847456.852847263 1.0 0.43244883235712 0.5376509446912666 24.98447342726289 -9.922628984163357 5.736465940206997 1.0000003399875523 0.48504988852392306 0.9696475479371559 0.042948582515568684 1.867549928104663e-07 3.510703162491241e-08 0.0415848140895574 0.013861595401881165 1.195008558993237e-10 9.922628984163357 -0.5149504514636293 VGLEHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGLEHLR 7 0 E7ENL6;P12111-4;P12111-2;P12111 E7ENL6 COL6A3 Collagen alpha-3(VI) chain 0 128054000.0 46991000.0 46191000.0 34872000.0 False True 60830775.831090786 43620430.24484769 28525653.816935934 1.0 0.7170783151930994 0.4689345718052866 25.858298068561673 -6.982144860568889 0.18439920337299884 1.18161343605789 1.0251804672244107e-08 0.9999964405654589 0.0004092888378065572 0.07438730628033244 0.005805744964212395 0.009168462861542385 0.027195537056155267 1.0419698184447062e-07 6.982144860568889 -1.1816134258060853 down VGLGICYDMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGLGICYDMR 10 0 Q9NQR4;H7C579 Q9NQR4 NIT2 Omega-amidase NIT2 0 7591200.0 2532100.0 2725600.0 2333500.0 False True 3319607.620891285 2318951.104305588 2092051.8045125746 1.0 0.6985618088450377 0.6302105680643296 21.662581293773293 -13.999999999999998 0.208500008192385 2.7326663300090797 0.5893614196665422 0.9994892234382514 0.0036307856717654858 12.711985572486338 0.14473896026985456 9.01647028993505 0.04091758605135292 1.0000000000000041e-14 13.999999999999998 -2.1433049103425375 VGLGICYDMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGLGICYDMR 10 0 Q9NQR4;H7C579 Q9NQR4 NIT2 Omega-amidase NIT2 0 9113200.0 2532100.0 3042500.0 3538600.0 False True 3468285.7974295784 2908072.2897979403 2702855.559754625 1.0 0.8384753909130486 0.7793058927720921 21.725791355296185 -13.999999999997103 0.13961989750002415 1.7713199278710159 0.7057441321292609 0.9996044499839938 0.0018550269936355036 11.933651874769055 0.11704262404130818 2.5083082819360647 0.06574672282906178 1.0000000000066711e-14 13.999999999997103 -1.065575795741755 VGLIGSCTNSSYEDMGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGLIGSCTNSSYEDMGR 17 0 Q99798;A2A274 Q99798 ACO2 Aconitate hydratase, mitochondrial 0 8857700.0 1690000.0 3338200.0 3829500.0 False True 2215606.365983278 2840153.5722016837 3433260.075157876 1.0 1.2818854539358726 1.5495803441755358 21.079270158162505 -6.971751749308065 0.2122172765124462 0.8637506011656457 1.9752069220870538 0.9999930122158251 0.0005931342291014679 0.07573827428303963 0.006958637770262081 0.007876893213481609 0.027599134825851288 1.0672059814243038e-07 6.971751749308065 1.1114563209214081 VGLIGSCTNSSYEDMGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGLIGSCTNSSYEDMGR 17 0 Q99798;A2A274 Q99798 ACO2 Aconitate hydratase, mitochondrial 0 7065000.0 1690000.0 2209500.0 3165500.0 False True 2314838.670532749 2111876.984160576 2417874.0955189234 1.0 0.9123214550733842 1.044510844879942 21.142480219685396 -6.727857385977503 1.7308423768547658 0.9471104161943272 1.0444047771151606 0.5493821326588215 0.036864647728411 0.34027522902231705 1.9960600836375633 0.01688453698387945 0.04200305385337134 1.8712965375649372e-07 6.727857385977503 0.09729436092083332 VGLIHDVFQLVGAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGLIHDVFQLVGAGR 15 0 Q6P179-3;Q6P179;D6RGW0 Q6P179-3 ERAP2 Endoplasmic reticulum aminopeptidase 2 0 23382200.0 9872300.0 5858900.0 7651000.0 False True 9558909.240323797 8198389.323759865 5646973.574919975 1.0 0.8576699618796835 0.5907550153419692 23.188414572116464 -6.961284169057343 0.4169450028492641 1.0121934042623655 0.4262132094044863 0.9998148909184523 0.0023079520551985565 0.07924558762555456 0.019459982813552906 0.003446633723392563 0.022237890669673566 1.0932407991161249e-07 6.961284169057343 -0.5859801948578791 VGLIHDVFQLVGAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGLIHDVFQLVGAGR 15 0 Q6P179-3;Q6P179;D6RGW0 Q6P179-3 ERAP2 Endoplasmic reticulum aminopeptidase 2 0 26114900.0 9872300.0 7397500.0 8845100.0 False True 8209254.867044864 7357648.199211213 10694569.51487835 1.0 0.8962626107209399 1.3027454608347588 22.96881984755074 -6.839022546884222 1.286959877388705 0.9448057689715648 1.3158557376788562 0.9227563049432506 0.047928019029826456 0.16994263289503814 0.5471863653594822 0.029206988630808353 0.06726942585559303 1.448696640884471e-07 6.839022546884222 0.37104996870729146 VGLK(ub)GQPAIIDGELYNEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGLKGQPAIIDGELYNEVK 19 1 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 1 10225800.0 2460300.0 4426200.0 3339300.0 True False 3225477.12557909 3765828.213192467 2993781.2688274398 1.0 1.1675259400627014 0.9281669508941093 21.6210811549121 -6.718549625061422 1.764389275503852 1.1020783690753506 0.9285668726372164 0.5056981459248742 0.0705085051356409 0.3581592552342175 2.178203887367923 0.03173906899255385 0.07981753217644838 1.911834854541638e-07 6.718549625061422 -0.17351149643813424 VGLK(ub)GQPAIIDGELYNEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGLKGQPAIIDGELYNEVK 19 1 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 1 20630400.0 5080300.0 8257300.0 7292800.0 True False 4919028.657315621 11554482.95125064 5382596.900689628 1.0 2.3489358888094127 1.0942397931926224 22.22994202927395 -6.6290373875675614 2.0835194042850556 1.8893349332390206 1.099238803754739 0.11403614736887091 0.5787661699236422 0.5616465711133166 4.644834387572368 0.22727001618752074 0.6413397650325076 2.349430554233575e-07 6.6290373875675614 -0.7900961294842817 VGLK(ub)GQPAIIDGELYNEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGLKGQPAIIDGELYNEVK 19 1 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 1 16987500.0 5080300.0 8421700.0 3485500.0 True False 4224494.545450203 8376330.630523437 4214301.9348688545 1.0 1.982800673643851 0.9975872591450435 22.010347304708226 -6.646713560077992 2.0200818890555734 1.6393774551562508 1.0017024302296942 0.18094081048612443 0.4198078674338376 0.5166035279715014 4.036860799740363 0.16875447014833167 0.46498640995982043 2.2557264912122955e-07 6.646713560077992 -0.6376750249265566 VGLNWLALVHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGLNWLALVHK 11 0 Q9H4L7-3;Q9H4L7;Q9H4L7-2 Q9H4L7-3 SMARCAD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 0 13192600.0 4234500.0 3420400.0 5537700.0 False True 5551470.506956336 2910089.652614778 4964711.925369304 1.0 0.5242015874835786 0.8943057373984447 22.40443854116381 -9.834004917942163 6.357372280690013 1.0000000112421517 0.7092536624409397 0.45140774368148606 0.15109438649658538 2.4052124219124498e-08 4.4577922666519705e-09 0.14629651719152043 0.048765503550520235 1.4655312452149772e-10 9.834004917942163 -0.290746348801212 VGLNWLALVHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGLNWLALVHK 11 0 Q9H4L7-3;Q9H4L7;Q9H4L7-2 Q9H4L7-3 SMARCAD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 0 12547500.0 4386500.0 2145700.0 6015300.0 False True 4247252.95854871 3002489.19967768 4439712.474868138 1.0 0.7069249769158166 1.0453138812775569 22.01809860482275 -6.677619134544109 1.910044347628381 0.8141782429169866 1.0440129699804301 0.3134137654828453 0.12427643703682249 0.44382237721175555 3.128344646879868 0.05224479694960175 0.13822914741351555 2.1007814090502626e-07 6.677619134544109 0.22983472706344354 VGLNWLALVHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGLNWLALVHK 11 0 Q9H4L7-3;Q9H4L7;Q9H4L7-2 Q9H4L7-3 SMARCAD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 0 15533600.0 4234500.0 5073100.0 6226000.0 False True 5800109.08305973 4848953.66750171 4755547.028494964 1.0 0.8360107711877279 0.819906481135743 22.4676486026867 -13.999999999999984 0.32811180118747774 2.7649653153427955 0.81699098387764 0.9997109044493598 0.0013834578408819598 18.66480765655293 0.18306814538730257 22.710986741646536 0.005197291641114844 1.0000000000000368e-14 13.999999999999984 -1.9479743314651556 VGLNWLALVHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGLNWLALVHK 11 0 Q9H4L7-3;Q9H4L7;Q9H4L7-2 Q9H4L7-3 SMARCAD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 0 9482500.0 4386500.0 1393700.0 3702300.0 False True 3647569.104898795 1386191.861472211 4476433.812498909 1.0 0.38003169278150584 1.2272375611710615 21.798503880257027 -6.7105458404096 1.7933056252818602 0.6190702478989017 1.2252757138473949 0.467682476040291 0.26122876623250596 0.37397487372355875 2.3447726497461963 0.11590860991419262 0.2942624694409889 1.9473954886884824e-07 6.7105458404096 0.6062054659484931 VGLQVVAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGLQVVAVK 9 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 1387530000.0 473340000.0 484160000.0 430030000.0 False True 620553323.8310801 411925215.2408985 385534620.73903626 1.0 0.6638030922110217 0.6212755712254989 29.208979944831302 -13.999999999999998 0.2915313373483565 3.9221450293377886 0.6098644486043181 0.9996308892992684 0.003254562690466687 16.05740092234804 0.17125793484423668 28.166096857073935 0.015951250778235768 1.0000000000000041e-14 13.999999999999998 -3.3122805807334705 VGLQVVAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGLQVVAVK 9 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 895240000.0 266150000.0 188230000.0 440860000.0 False True 257701213.93314472 263391220.60648236 325385540.4834947 1.0 1.0220798597976872 1.2626465181025857 27.941124092304204 -6.92483307133644 0.7880318204316585 0.9955584057830574 1.3061103876599727 0.9954220340914343 0.00804826934414483 0.09541044098089459 0.09147826832937028 0.007118330207731412 0.022417146432375135 1.1889591368151598e-07 6.92483307133644 0.31055198187691524 VGLQVVAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGLQVVAVK 9 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 1273579400.0 248677500.0 627300000.0 397601900.0 False True 377261948.2604663 515353413.88272893 319015710.18989646 1.0 1.3660360294988527 0.8456079699022391 28.490991352158748 -6.717706760478607 1.767800369583374 1.2232368574557242 0.8465340473230807 0.5015937477835923 0.15407398513677814 0.35977900210485414 2.1961347042505284 0.0692403933549536 0.17427454686053115 1.9155488842151566e-07 6.717706760478607 -0.3767028101326435 VGLQVVAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGLQVVAVK 9 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 1140810000.0 473340000.0 219620000.0 447850000.0 False True 648346589.5325278 209916462.21377957 342077053.76027465 1.0 0.3237719849272809 0.5276144878110947 29.272190006354194 -10.11298734811556 5.646010461289304 1.0000055985045986 0.4256932363695808 0.9136717228141569 0.08321835332647054 5.905066295381315e-06 9.277418570858567e-07 0.08057661433665617 0.026858608044311554 7.709259273826469e-11 10.11298734811556 -0.5743123621350178 VGLQVVAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGLQVVAVK 9 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 584590000.0 266150000.0 162940000.0 155500000.0 False True 221315517.4441615 162062209.87894225 188014331.04923445 1.0 0.7322677223472637 0.8495307207578473 27.72152936773848 -10.165039193239192 4.703320000983737 1.0000241399954162 0.7908992215522687 0.809146858591593 0.04787241864261281 1.241678159130349e-05 2.2043632733762263e-06 0.04635774891642357 0.015450756677814875 6.838499299342713e-11 10.165039193239192 -0.2091249184431475 VGLQVVAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGLQVVAVK 9 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 1258386700.0 248677500.0 645447900.0 364261300.0 False True 321917925.9163687 609528156.9706967 297969481.0365632 1.0 1.8934271996056735 0.9256069856574962 28.262117674251197 -6.664101026381105 1.958513371309295 1.573134535859334 0.9296183819530031 0.25316325669041173 0.38003091000742034 0.47475967577509554 3.504965979633456 0.15654355564273084 0.42145395504853367 2.167199908149991e-07 6.664101026381105 -0.643516153906331 VGLTNYAAAYCTGLLLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGLTNYAAAYCTGLLLAR 18 0 P46777;A0A2R8Y6J3;Q5T7N0;A0A2R8Y4A2 P46777 RPL5 60S ribosomal protein L5 0 27913200.0 8330100.0 13428000.0 6155100.0 False True 10920841.768803163 11424594.741934048 5518229.295888296 1.0 1.046127668891781 0.5052934025334799 23.380580726410113 -6.886164858363889 1.0448500300443038 1.0317874085643566 0.46213469103403826 0.9783260959652655 0.036040293936086425 0.12230801004346557 0.24049055673550135 0.026406366254362976 0.06498242541158054 1.299676126789981e-07 6.886164858363889 -0.5696527175303183 VGLTNYAAAYCTGLLLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGLTNYAAAYCTGLLLAR 18 0 P46777;A0A2R8Y6J3;Q5T7N0;A0A2R8Y4A2 P46777 RPL5 60S ribosomal protein L5 0 37323100.0 26210000.0 5997800.0 5115300.0 False True 25377977.89662863 8392752.818113813 3775449.4742893954 1.0 0.3307100688754544 0.1487687273457256 24.59707378481977 -13.99999999998508 0.18278938978136236 4.5029890736269556 0.008330247817624899 0.9994950386246677 0.008224654911920598 12.24208904450885 0.13555442408756702 15.241039491879668 0.13269078284347743 1.0000000000343536e-14 13.99999999998508 -4.4946588258093305 VGLTNYAAAYCTGLLLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGLTNYAAAYCTGLLLAR 18 0 P46777;A0A2R8Y6J3;Q5T7N0;A0A2R8Y4A2 P46777 RPL5 60S ribosomal protein L5 0 132894000.0 0.0 91507000.0 41387000.0 False True 0.0 75176860.90254578 33206841.30943353 0.0 VGLTNYAAAYCTGLLLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGLTNYAAAYCTGLLLAR 18 0 P46777;A0A2R8Y6J3;Q5T7N0;A0A2R8Y4A2 P46777 RPL5 60S ribosomal protein L5 0 42373100.0 8330100.0 10807000.0 23236000.0 False True 11409963.082488103 10329511.006030023 17748135.36044153 1.0 0.9053062600950614 1.5554945473645914 23.443790787933004 -6.869916904010096 1.134610246046189 0.9464773243157067 1.593500402533926 0.9645963417505974 0.05396380362321695 0.1369306218142928 0.32952563329084794 0.03691499171420154 0.08738039116108041 1.3492210118913726e-07 6.869916904010096 0.6470230782182194 VGLTNYAAAYCTGLLLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGLTNYAAAYCTGLLLAR 18 0 P46777;A0A2R8Y6J3;Q5T7N0;A0A2R8Y4A2 P46777 RPL5 60S ribosomal protein L5 0 49864300.0 26210000.0 3558300.0 20096000.0 False True 21794776.29987399 3539130.7316327537 24297980.686594315 1.0 0.16238435682651242 1.1148534103896628 24.377479060254046 -6.674469313664555 1.921646406465054 0.4674245714107284 1.1110808225107753 0.2989934929898016 0.355437842897057 0.45090456778757004 3.2142373336785366 0.14868866120534216 0.39494133580040186 2.116073197244086e-07 6.674469313664555 0.643656251100047 VGLTNYAAAYCTGLLLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGLTNYAAAYCTGLLLAR 18 0 P46777;A0A2R8Y6J3;Q5T7N0;A0A2R8Y4A2 P46777 RPL5 60S ribosomal protein L5 0 91099000.0 0.0 54435000.0 36664000.0 False True 0.0 51405644.39778927 29991528.204408653 0.0 VGLVAK(ub)GLLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGLVAKGLLLK 11 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7ER69;K7EJ09;K7EKY0 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 150179000.0 45362000.0 62750000.0 42067000.0 True False 59470021.28623286 53387944.5975843 37714310.375157684 1.0 0.8977286949440433 0.6341734803429175 25.82565925631269 -6.954808180317863 0.5032996551106561 1.005130555372446 0.5153402916861123 0.999526577928711 0.0033531673181337834 0.08161057074713557 0.028402350066687895 0.003908421419097349 0.021743728022046355 1.1096648250660451e-07 6.954808180317863 -0.4897902636863338 VGLVAK(ub)GLLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGLVAKGLLLK 11 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7ER69;K7EJ09;K7EKY0 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 241446860.0 49337860.0 106563000.0 85546000.0 True False 47771656.640479125 149114161.6187038 63138936.275010295 1.0 3.1213939834850213 1.3216819494074183 25.50965157211894 -6.605895754512761 2.1679801129704295 2.4211084277747874 1.327757534300947 0.03811059795544458 0.9155364564784106 0.62404210402513 5.551481339485632 0.3493863387032768 1.0176735207780436 2.478016794795165e-07 6.605895754512761 -1.0933508934738405 VGLVAK(ub)GLLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGLVAKGLLLK 11 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7ER69;K7EJ09;K7EKY0 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 438444000.0 155916000.0 118299000.0 164229000.0 True False 236535970.98643336 97187619.17569421 131769066.16587222 1.0 0.41087881378206303 0.5570783404162655 27.817484355845764 -10.263996893330354 8.413808884181387 1.000000331190798 0.4839785770994804 0.9432156406731625 0.05968570681503915 3.7075254480469985e-07 3.244466281488116e-08 0.057790474152151085 0.01926347904177211 5.4450654788595596e-11 10.263996893330354 -0.5160217540913175 VGLVAK(ub)GLLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGLVAKGLLLK 11 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7ER69;K7EJ09;K7EKY0 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 179102000.0 45362000.0 64419000.0 69321000.0 True False 62133557.26195659 61572755.574854136 52948807.51080949 1.0 0.9909742543029028 0.8521773071446084 25.88886931783558 -6.920125057006138 0.8238050356233635 1.0030487948646625 0.8297310413748762 0.9942153304526247 0.005145809877569907 0.09809867338275158 0.10523593547576746 0.00443655182741298 0.013305383071589705 1.201918287125514e-07 6.920125057006138 -0.17331775348978629 VGLVAK(ub)GLLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGLVAKGLLLK 11 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7ER69;K7EJ09;K7EKY0 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 186606860.0 49337860.0 81138000.0 56131000.0 True False 41026616.627794765 80700893.48936792 67867732.57957938 1.0 1.9670375020565203 1.6542366433794655 25.290056847553217 -10.128516129910375 5.1247464266759595 0.9999738265143767 1.810637072714462 0.8995459257642047 0.12770041581772082 4.0436583727773614e-05 6.876690447938075e-06 0.12364960908774565 0.04121513197942936 7.438474355354033e-11 10.128516129910375 0.8106632462000853 VGLVAK(ub)GLLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGLVAKGLLLK 11 1 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7ER69;K7EJ09;K7EKY0 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 1 361353000.0 155916000.0 104630000.0 100807000.0 True False 201836335.5638386 98807248.52283803 82461160.36716734 1.0 0.4895414309163693 0.4085545852624033 27.588610677938213 -13.999999999999998 0.25912629933907183 4.719839981964126 0.37870577698627167 0.9995605559570625 0.00548845141481658 14.37863943312927 0.16108380978665718 27.99296611809628 0.03556999211234063 1.0000000000000041e-14 13.999999999999998 -4.3411342049778545 VGLYTIYVNPANTHQFAVGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGLYTIYVNPANTHQFAVGGR 21 0 Q5TAQ9;V9GY54 Q5TAQ9 DCAF8 DDB1- and CUL4-associated factor 8 0 17953900.0 4919300.0 7155400.0 5879200.0 False True 6449249.938568971 6087842.211530741 5270876.781268615 1.0 0.9439612775934029 0.8172852395976724 22.620699951126685 -6.957581503961241 0.46827439059441855 1.0034025850814605 0.7526658899751273 0.9996697143351039 0.0013889814594769485 0.08057662146483455 0.024411106407355 0.0017458772472169891 0.010456618305941825 1.1026012894612729e-07 6.957581503961241 -0.25073669510633323 VGLYTIYVNPANTHQFAVGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGLYTIYVNPANTHQFAVGGR 21 0 Q5TAQ9;V9GY54 Q5TAQ9 DCAF8 DDB1- and CUL4-associated factor 8 0 24834300.0 8120800.0 4985500.0 11728000.0 False True 7863009.649101171 6976236.149039044 8656084.967541695 1.0 0.887222127450461 1.1008615471470495 22.906650194117596 -6.763295151165154 1.600202864406786 0.9347602316792712 1.1017677975542342 0.7042083616681574 0.04745956846291463 0.2774239735181764 1.4008161959048666 0.023393410463205973 0.0560336044552689 1.724665392605508e-07 6.763295151165154 0.1670075658749629 VGLYTIYVNPANTHQFAVGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGLYTIYVNPANTHQFAVGGR 21 0 Q5TAQ9;V9GY54 Q5TAQ9 DCAF8 DDB1- and CUL4-associated factor 8 0 26773900.0 4919300.0 7882600.0 13972000.0 False True 6738098.14908389 7534320.667727613 10672101.362372573 1.0 1.1181672485361434 1.5838447476197048 22.683910012649577 -6.945217877967765 0.6090961566229931 0.9948422721761803 1.731382811111962 0.9987704652195394 0.0088375273957475 0.08546491071654443 0.04436241998714472 0.008990853762174917 0.03925460465190342 1.1344415433488624e-07 6.945217877967765 0.7365405389357818 VGMEINHLHALFMSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGMEINHLHALFMSR 15 0 Q9Y6Y8;Q9Y6Y8-2 Q9Y6Y8 SEC23IP SEC23-interacting protein 0 5050600.0 1023900.0 1963800.0 2062900.0 False True 1402463.4998570909 1877032.822581827 1575685.5067591167 1.0 1.3383826550730868 1.123512666760794 20.41953179344851 -10.183238640143202 3.86476423450281 0.9998580648155814 1.2309476605005987 0.6063506634960827 0.0877203064370734 62050824.601493075 117158079.77658355 123883.21209867376 0.032102331793112844 6.55784820581197e-11 10.183238640143202 0.2310895956850173 VGMGSGSICITQEVLACGRPQATAVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGMGSGSICITQEVLACGRPQATAVYK 27 1 P12268 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 11162100.0 4556000.0 4854700.0 1751400.0 False True 5972960.120366758 4130397.683472383 1570181.9286150953 1.0 0.6915160322916678 0.262881703037167 22.51001465870107 -7.194236039303212 0.37774051329170333 1.0357947141279236 1.4665180147568965e-11 0.9997699639069251 0.0045843089501299 0.08796993224169052 0.022672609394662757 0.008660810173644076 0.04264333362953653 6.393872336973601e-08 7.194236039303212 -1.0357947141132584 down VGMGSGSICITQEVLACGRPQATAVYK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VGMGSGSICITQEVLACGRPQATAVYK 27 1 P12268 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 190307000.0 35709000.0 109406000.0 45192000.0 False True 54173163.67758637 89881644.50702041 36259781.39164276 1.0 1.6591544300782288 0.6693310659765823 25.691075009934448 -6.727211233863545 1.733312479890527 1.3979174514650037 0.6702141883475868 0.5462214568027122 0.27716149724948985 0.3415468326972108 2.008956831774589 0.12678118784727627 0.31560739937300897 1.8740827625882606e-07 6.727211233863545 -0.7277032631174168 VGMGSGSICITQEVLACGRPQATAVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGMGSGSICITQEVLACGRPQATAVYK 27 1 P12268 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 18313900.0 4556000.0 3706900.0 10051000.0 False True 6240476.3212705385 3543116.90092095 7677160.8068427425 1.0 0.5677638562371123 1.2302203247972103 22.573224720223962 -6.730644332707114 1.7209153649832034 0.7400669733194677 1.2298695905117907 0.5622214558598901 0.18169286983534877 0.3350387029117136 1.94417812996355 0.08365786792434059 0.20743731099077667 1.859326535037173e-07 6.730644332707114 0.489802617192323 VGMGSGSICITQEVLACGRPQATAVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VGMGSGSICITQEVLACGRPQATAVYK 27 1 P12268 P12268 IMPDH2 Inosine-5-monophosphate dehydrogenase 2 0 111734500.0 35709000.0 41391000.0 34634500.0 False True 46226004.42962312 39087554.46438684 28331376.379980143 1.0 0.8455750166315104 0.61288828073197 25.462201332026897 -6.965182097229497 0.354914896355145 1.0212521490102247 0.4292998377035851 0.9999168469140094 0.0014508913387938638 0.0778992584717262 0.014642479507247102 0.0031562869003867113 0.0199365761245014 1.0834725248409427e-07 6.965182097229497 -0.5919523113066396 VGNIEIK(ub)DLMVGDEASELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGNIEIKDLMVGDEASELR 19 1 P61160 P61160 ACTR2 Actin-related protein 2 1 9201400.0 3259700.0 3543200.0 2398500.0 True False 4273498.266979701 3014568.3712854236 2150326.2280365992 1.0 0.7054099903534002 0.5031770445893604 22.02698610665496 -8.008933391766014 0.1276183313293106 1.4150472698127416 1.439313151792183e-10 0.9999735606271456 0.0010488950891975272 0.10582774833451741 0.021394957705109956 0.10094687726046866 0.11852011796214336 9.796402224120146e-09 8.008933391766014 -1.4150472696688103 VGNIEIK(ub)DLMVGDEASELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGNIEIKDLMVGDEASELR 19 1 P61160 P61160 ACTR2 Actin-related protein 2 1 11902300.0 3259700.0 4539600.0 4103000.0 True False 4464899.18008024 4339025.461550287 3133955.9039374962 1.0 0.9718081610685573 0.7019096686257483 22.09019616817785 -6.926916787171685 0.7716794944058857 1.0046075483780914 0.6506140394733544 0.9958968097126703 0.00860722683947183 0.09427071566037908 0.08575679232035657 0.007702285813713045 0.0248480423055973 1.18326825366805e-07 6.926916787171685 -0.353993508904737 VGNIEIK(ub)DLMVGDEASELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGNIEIKDLMVGDEASELR 19 1 P61160 P61160 ACTR2 Actin-related protein 2 1 69319200.0 11380000.0 9260200.0 48679000.0 True False 14731634.333336448 8744861.729629975 39819921.48871948 1.0 0.5936111046308752 2.703021306917071 23.81241415662228 -6.856781046969218 1.2019472977371595 0.7811384516974725 2.7990351881758455 0.9495976199012454 0.20514930866384573 0.15015778704604463 0.4140622783244661 0.13328754130638432 0.3100800109802566 1.390653563606282e-07 6.856781046969218 2.017896736478373 up VGNLGLATSFFNEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGNLGLATSFFNEK 14 0 O15523-2;O15523 O15523-2 DDX3Y ATP-dependent RNA helicase DDX3Y 0 7062800.0 2640400.0 2247900.0 2174500.0 False True 3461589.969669976 1912522.0822455708 1949503.5992768756 1.0 0.552498158072693 0.5631815484670876 21.7230034148383 -9.94677287991742 5.07880466697779 1.0000019520860817 0.557839853284569 0.9995623459790921 0.004361475888297897 5979811.046204183 2.839796246329684 138.39733607907442 0.0014930492014577454 1.130386911012501e-10 9.94677287991742 -0.4421620988015127 VGNLGLATSFFNEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGNLGLATSFFNEK 14 0 O15523-2;O15523 O15523-2 DDX3Y ATP-dependent RNA helicase DDX3Y 0 7739700.0 2640400.0 2163000.0 2936300.0 False True 3616627.234127031 2067431.5079155138 2242806.414996749 1.0 0.5716462809346021 0.6201375673537197 21.78621347636119 -10.742029682432484 10.58547609679186 1.0007512057424546 0.5958919243461188 0.9893161264154581 0.019796484782998298 0.00035149612552992155 8.566023021425172e-06 0.01919705946633453 0.006389287989833407 1.811216298408605e-11 10.742029682432484 -0.40485928139633576 VGNLGLATSFFNER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGNLGLATSFFNER 14 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 0 87689000.0 24151000.0 28378000.0 35160000.0 False True 31662194.878616698 24144113.016577598 31521980.478535287 1.0 0.7625533576916838 0.995571551479013 24.91625793329175 -10.783198737757404 9.084215804419415 1.0012974531862917 0.8790624545981393 0.2642484986260243 0.09512927926065431 0.002524716220471518 6.0254073922099666e-05 0.09302871992896163 0.030702842859435715 1.6474083474909868e-11 10.783198737757404 -0.12223499858815245 VGNLGLATSFFNER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGNLGLATSFFNER 14 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 0 103394000.0 36106000.0 17879000.0 49409000.0 False True 34959834.793425165 25018177.93775331 36467300.66177245 1.0 0.715626320478449 1.0431199368433741 25.05919503145081 -6.677063942348536 1.9118891049104858 0.819609290648486 1.0418604155339601 0.3109715684003249 0.12060102947686535 0.4450522675922017 3.142546254356514 0.05065843010668371 0.1341339820244164 2.1034687175908145e-07 6.677063942348536 0.22225112488547416 VGNLGLATSFFNER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGNLGLATSFFNER 14 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 0 72869000.0 13893000.0 37649000.0 21327000.0 False True 21076696.71434952 30930241.79702035 17111709.102043815 1.0 1.4675089847434348 0.8118781293841816 24.329145439760733 -6.715258223544617 1.7766808137205832 1.285857271373131 0.8131795686592527 0.48997995574571707 0.19685158624799676 0.3645782885520304 2.246462838909496 0.08807151965745295 0.22230970736946226 1.9263791828300424e-07 6.715258223544617 -0.47267770271387843 VGNLGLATSFFNER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGNLGLATSFFNER 14 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 0 115478000.0 24151000.0 45993000.0 45334000.0 False True 33080277.35623461 43960877.1814879 34627042.88303738 1.0 1.3289150120503037 1.0467579370676363 24.97946799481464 -10.546624573841083 8.63148508455162 0.9999770661642481 1.18783647455897 0.37142643831885824 0.11519014350395798 5.084311128493457e-05 2.6705006375811266e-06 0.11154597016771316 0.03717745895317264 2.8403733301256258e-11 10.546624573841083 0.18785940839472193 VGNLGLATSFFNER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGNLGLATSFFNER 14 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 0 68574000.0 36106000.0 12975000.0 19493000.0 False True 30023738.767006885 12905101.099664142 23568896.17455129 1.0 0.4298299155815188 0.7850087011965069 24.839600306885085 -10.07365159904967 5.183615245319513 1.0000061957693531 0.6074193083882141 0.6196171877946048 0.1450011320392064 1.038266334208409e-05 1.855580581780031e-06 0.14039895608269307 0.04679891413034484 8.440115716056394e-11 10.07365159904967 -0.392586887381139 VGNLGLATSFFNER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGNLGLATSFFNER 14 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A0J9YVQ7;A0A087WVZ1 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 0 67896000.0 13893000.0 28796000.0 25207000.0 False True 17984762.371972155 27193477.286281638 20619584.645661373 1.0 1.5120287231962846 1.1465030351357537 24.100271761853183 -10.066185911049628 8.88699738773799 0.999999998345354 1.329265879166019 0.5196748579748175 0.149225237271339 5.133272530012915e-09 2.4226628058561115e-10 0.1444867146964364 0.048162238232145514 8.586458771187744e-11 10.066185911049628 0.329265880820665 VGQAMASTEEK(ub)AYEIMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGQAMASTEEKAYEIMR 17 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 23810600.0 3028500.0 2201100.0 18581000.0 True False 3970392.828035717 1872704.4598205998 16658416.361537648 1.0 0.47166729866049245 4.195659493415696 21.92085032304559 -6.8709554531278885 1.1290946469948604 0.6994258192930968 4.417689695548714 0.9656241918684291 0.30502773172466374 0.13593863131315564 0.32332689632911604 0.2095439666112944 0.49691938034347694 1.3459984100214247e-07 6.8709554531278885 3.7182638762556173 up VGQAMASTEEK(ub)AYEIMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGQAMASTEEKAYEIMR 17 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 27833500.0 2200900.0 3158600.0 22474000.0 True False 2131033.6342117502 4419845.451881396 16587385.194451887 1.0 2.0740383356343672 7.783727543365315 21.023121932753362 -6.938447469441022 0.6738520102690105 0.9338638658027468 9.255584171643552 0.9979533990922238 0.1346863163338547 0.08848211160923114 0.057888905998959524 0.12961328853349244 0.4948774545136683 1.1522654249083648e-07 6.938447469441022 8.321720305840804 VGQAMASTEEK(ub)AYEIMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGQAMASTEEKAYEIMR 17 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 86573000.0 3724000.0 34105000.0 48744000.0 True False 5649580.260867895 28018696.28641878 39109727.034745835 1.0 4.95942972622085 6.922589861346222 22.429712254894678 -8.692694903646169 0.3445876277330463 8.417152857482147e-20 7.60504228528737 0.9980210743102772 0.10957771206685021 0.2742073372972555 0.10944170453440895 0.9266656310029798 0.5637142337068721 2.029107688018775e-09 8.692694903646169 7.60504228528737 VGQAMASTEEK(ub)AYEIMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGQAMASTEEKAYEIMR 17 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 25419200.0 3028500.0 2519700.0 19871000.0 True False 4148218.2921351683 2408371.3224663516 15177879.05609115 1.0 0.5805796978024308 3.658891115944335 21.98406038456848 -6.872500541503483 1.120839126457788 0.7588185409370282 3.847906635211374 0.9671129722985151 0.24718959574169158 0.13447704207271077 0.31423688122451354 0.17088908794151128 0.4064209126677343 1.3412182630958103e-07 6.872500541503483 3.089088094274346 up VGQAMASTEEK(ub)AYEIMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGQAMASTEEKAYEIMR 17 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 29231600.0 2200900.0 5034700.0 21996000.0 True False 1830145.8664018572 5007577.0717903 26595261.901986882 1.0 2.736162818341581 14.531771696577536 20.80352720818764 -6.933265213046871 0.719484203988526 0.8405361669553002 17.167831009409845 0.9971419905491439 0.32138497363436086 0.09097745574693843 0.06963158458577054 0.29870667217757163 1.0487959005906 1.1660972924101996e-07 6.933265213046871 16.327294842454545 VGQAMASTEEK(ub)AYEIMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGQAMASTEEKAYEIMR 17 1 P46977;P46977-2 P46977 STT3A Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A 1 67584000.0 3724000.0 20188000.0 43672000.0 True False 4820791.411014493 19064520.05332175 35724144.112561 1.0 3.9546452911784025 7.410431414007845 22.200838576987127 -6.969061799049305 0.27968776270858575 0.2358062863260966 11.23453075545428 0.9999741120122781 0.013329156016667449 0.07660831135530567 0.010115169270030179 0.06394752473169639 0.3173229319673688 1.0738365971308695e-07 6.969061799049305 10.998724469128183 VGQAVDVVGQAGK(ub)PK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGQAVDVVGQAGKPK 15 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 40067260.0 10837000.0 12788000.0 16442260.0 True False 10492985.366873894 17894315.088539 12135538.8487732 1.0 1.7053597677769503 1.1565382419272983 23.322921862740248 -10.268819246529391 4.035163042559259 0.9995330757976925 1.4309490047951687 0.4511847401287238 0.2240554500141418 79284412.25368324 289.40135450322407 355828.4171293347 0.07670014001668322 5.384938571594132e-11 10.268819246529391 0.4314159289974763 VGQAVDVVGQAGK(ub)PK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGQAVDVVGQAGKPK 15 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 104252900.0 21396200.0 29911300.0 52945400.0 True False 32459599.671745826 24573394.81694644 42480718.48320685 1.0 0.7570455293795917 1.3087258904238372 24.95214187127091 -6.787040705853844 1.5085694587132294 0.8636868850216843 1.3140891747795207 0.7914511873351504 0.10309607540799326 0.2397969149017736 1.078199266008897 0.05380619981807917 0.1262270528125429 1.6328988912438795e-07 6.787040705853844 0.45040228975783636 VGQAVDVVGQAGK(ub)PK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGQAVDVVGQAGKPK 15 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 32680700.0 10837000.0 17098700.0 4745000.0 True False 9011445.660501132 17006585.90927377 5737157.561598824 1.0 1.8872206025518024 0.6366522950635845 23.103327138174524 -6.716151349803577 1.7730359494418344 1.5419903281875367 0.6389991410943904 0.4942805406607672 0.3735346969948435 0.3628875458723959 2.227295371616161 0.16741249968522934 0.42220268199334093 1.922421656282179e-07 6.716151349803577 -0.9029911870931463 VGQAVDVVGQAGK(ub)PK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGQAVDVVGQAGKPK 15 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 78996100.0 21396200.0 33117400.0 24482500.0 True False 27697802.68215578 31274387.577465694 20026936.211663645 1.0 1.1291288314944246 0.723051443519956 24.72326819336336 -6.82117554563074 1.3667839736865108 1.0695177370358642 0.7139609028470392 0.8870676417977438 0.0569282655741331 0.19195625375657813 0.7042942483784442 0.032728033669284326 0.07541008695119562 1.5094698898942746e-07 6.82117554563074 -0.355556834188825 VGQAVDVVGQAGKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGQAVDVVGQAGKPK 15 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 9962630.0 727030.0 5917000.0 3318600.0 False True 953143.3705685362 5034206.664285352 2975223.106259025 1.0 5.281688799117934 3.1214853904763014 19.862333713179748 -9.31345415582406 8.884571890660762 1.0000128030218138 4.201587094797884 0.7454651462476554 0.8818993486659322 0.0 0.0 0.8538953853121958 0.28463179086277524 4.858988197662551e-10 9.31345415582406 3.2015742917760703 VGQAVDVVGQAGKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGQAVDVVGQAGKPK 15 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 9348330.0 2755400.0 692630.0 5900300.0 False True 2667931.3352297083 969200.7710177343 4354834.424794188 1.0 0.3632780042797789 1.6322887951759213 21.34729010556243 -6.770299800081318 1.5734384634716263 0.6349328692872859 1.6394863928020889 0.7316665808854144 0.2683662857073521 0.2659407216313284 1.299421527878719 0.13444054680703327 0.3199190739472184 1.697071733601575e-07 6.770299800081318 1.004553523514803 VGQAVDVVGQAGKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGQAVDVVGQAGKPK 15 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 9720930.0 727030.0 4795600.0 4198300.0 False True 995832.6382469989 4583714.535071496 3206748.006702604 1.0 4.60289646977265 3.220167610038933 19.92554377470264 -9.71239299203762 7.991646659794215 0.999999999925317 3.9115320399057945 0.8553164957727504 0.5644966931613612 1.677146135878134e-09 0.0 0.5465715769730422 0.18219052430025548 1.9391303690032884e-10 9.71239299203762 2.9115320399804774 VGQAVDVVGQAGKPK(ub)TITGFQTHTTPVLLAHGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGER 34 2 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 10369900.0 2365200.0 2731400.0 5273300.0 True False 3100800.1046293825 2323885.766913811 4727669.501065414 1.0 0.7494471389640157 1.5246611653576685 21.56420909387024 -6.8196999211130604 1.3731045385716492 0.8649073768831992 1.541483840748736 0.8836904783296823 0.11015896260641386 0.1938835661316683 0.7183591214505258 0.06304357332446511 0.14532183969848705 1.5146074158225648e-07 6.8196999211130604 0.6765764638655367 VGQAVDVVGQAGKPK(ub)TITGFQTHTTPVLLAHGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGQAVDVVGQAGKPKTITGFQTHTTPVLLAHGER 34 2 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 13591300.0 2365200.0 6037000.0 5189100.0 True False 3239678.3571266662 5770265.378310666 3963541.452869135 1.0 1.781122920927381 1.223436716842618 21.62741915539313 -10.119520766294555 5.783724316296591 0.9999959403221018 1.5022798188850313 0.5195909465346364 0.22767443943299856 1.1918523447647886e-05 1.814071369730093e-06 0.2204466078331865 0.07348160935674292 7.594151094851051e-11 10.119520766294555 0.5022838785629294 VGQEIEVRPGIVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGQEIEVRPGIVSK 14 1 P41091 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 0 17463000.0 2203600.0 5527700.0 9731700.0 False True 2888940.939692757 4702988.706805839 8724757.037058072 1.0 1.6279282979409087 3.020053791056719 21.46210927967069 -6.957981886256726 0.46300851598920895 0.9606184062946013 3.743766090757194 0.9996878428434604 0.014913975643327922 0.08043019911659195 0.02385666980485696 0.019005184574891955 0.1149675895319869 1.1015852539805012e-07 6.957981886256726 2.783147684462593 VGQEIEVRPGIVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGQEIEVRPGIVSK 14 1 P41091 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 0 9633000.0 2952100.0 1625000.0 5055900.0 False True 2858387.2013978455 2273870.974263049 3731608.1162511953 1.0 0.7955083807928651 1.3054942711842243 21.44676992861986 -6.797907945170762 1.4647069579881806 0.8868715706994187 1.3121545311797769 0.8258955108882268 0.08743961363684626 0.2237617299137964 0.9479836554932353 0.04697150596294057 0.10936760311070678 1.592546253875772e-07 6.797907945170762 0.4252829604803582 VGQEIEVRPGIVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGQEIEVRPGIVSK 14 1 P41091 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 0 17249600.0 2203600.0 6578100.0 8467900.0 False True 3018330.470050872 6287457.791132241 6467956.421874806 1.0 2.0830912497882546 2.142892067668718 21.52531934119358 -10.8914472147923 0.5204260389096913 3.2684387543807783e-19 2.139257598671446 0.9997943920169026 0.007531390455371968 2.597349865532337 0.2525150198098424 3.1853154188128 0.011716086988496023 1.2839638170745555e-11 10.8914472147923 2.139257598671446 VGQEIEVRPGIVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGQEIEVRPGIVSK 14 1 P41091 P41091 EIF2S3 Eukaryotic translation initiation factor 2 subunit 3 0 4186600.0 2952100.0 0.0 1234500.0 False True 2454801.9502044306 0.0 1492628.242316914 1.0 0.0 0.6080442628753049 21.227175204054138 -10.121873801911983 6.764723571398572 1.0000007985726618 0.3040221314376522 0.6359485442694424 0.24823303084520423 2.9895836753641267e-06 3.8781436928187043e-07 0.24035087613930314 0.08011686620350553 7.553116756337265e-11 10.121873801911983 -0.6959786671350096 VGQGYPHDPPKVK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGQGYPHDPPKVK 13 1 P61081;M0QYI6 P61081 UBE2M NEDD8-conjugating enzyme Ubc12 1 8961700.0 3925200.0 3126700.0 1909800.0 True False 5081248.777259414 2952696.3964098063 1562235.996202805 1.0 0.5810966016118485 0.30745119254826203 22.276751669344904 -8.35955702946161 0.2074182864427374 1.2827433584129133 1.507171610181968e-09 0.9997095919969348 0.0048533309827758055 0.10852008442523844 0.04837533958783648 0.12488001876941741 0.11876219668082508 4.369612956482791e-09 8.35955702946161 -1.2827433569057416 down VGQIEDFLYQLEDSFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGQIEDFLYQLEDSFLK 17 0 Q9BXB7 Q9BXB7 SPATA16 Spermatogenesis-associated protein 16 0 46548000.0 16496000.0 13343000.0 16709000.0 False True 15972343.509453889 18670929.482825786 12332411.640744735 1.0 1.16895366492554 0.7721103439482935 23.9290726689721 -6.791012920955366 1.4921660555793528 1.09430341400727 0.767763986752679 0.8046291053509306 0.07187270571721473 0.23384203303754436 1.0285449062621888 0.03790972372976014 0.08869540645842723 1.6180318978904137e-07 6.791012920955366 -0.32653942725459106 VGQIEDFLYQLEDSFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGQIEDFLYQLEDSFLK 17 0 Q9BXB7 Q9BXB7 SPATA16 Spermatogenesis-associated protein 16 0 39337500.0 9895500.0 15875000.0 13567000.0 False True 15012196.957953323 13041982.218058886 10885476.503372656 1.0 0.8687590666833988 0.7251088254344833 23.839631787633163 -6.969966049712719 0.2589996530236297 1.040825684994678 0.5487858972751019 0.9999821128946569 0.00047475609404639183 0.07631375720892836 0.00906974463324597 0.003018220357845123 0.013574055091415172 1.0716030728462334e-07 6.969966049712719 -0.4920397877195761 VGQIEDFLYQLEDSFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGQIEDFLYQLEDSFLK 17 0 Q9BXB7 Q9BXB7 SPATA16 Spermatogenesis-associated protein 16 0 40374700.0 16496000.0 14056000.0 9822700.0 False True 13717154.896708194 13980277.53810246 11876581.154966675 1.0 1.019182012842722 0.865819570049237 23.709477944406377 -6.875553029252183 1.104351146758317 1.0113129197174449 0.8558388414075011 0.9699155402273897 0.01183361134574755 0.13163961935516033 0.29674021839123044 0.008284997161833825 0.01982674696588264 1.3318244108096247e-07 6.875553029252183 -0.15547407830994375 VGQIEDFLYQLEDSFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGQIEDFLYQLEDSFLK 17 0 Q9BXB7 Q9BXB7 SPATA16 Spermatogenesis-associated protein 16 0 38964100.0 9895500.0 20257000.0 8811600.0 False True 12809919.819466662 19129680.142665897 7207979.214651088 1.0 1.49334893678221 0.5626873014222498 23.610758109725612 -6.762646247219022 1.6022130208810499 1.2856093299315299 0.5587967250481021 0.7018304415536871 0.2075917514018121 0.2784721507301435 1.4094390734081774 0.10219437762444411 0.24498091243705597 1.72724423882407e-07 6.762646247219022 -0.7268126048834278 VGQQAIVLCISPSKPNPVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGQQAIVLCISPSKPNPVFK 20 1 C9JP85;Q16656-2;Q16656;Q16656-4 C9JP85 NRF1 Nuclear respiratory factor 1 0 6157600.0 1887500.0 2705400.0 1564700.0 False True 2474530.7785759983 2301764.865566604 1402799.8536622361 1.0 0.9301823543658588 0.5668952941735063 21.23872355609276 -6.938920591294217 0.6695370662605328 1.0041638882939439 0.47196498756213956 0.9980189675815687 0.008450571132490427 0.08826277440917966 0.05687971493639832 0.008160165179089065 0.03141907403702936 1.151010826627498e-07 6.938920591294217 -0.5321989007318043 VGQQAIVLCISPSKPNPVFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGQQAIVLCISPSKPNPVFK 20 1 C9JP85;Q16656-2;Q16656;Q16656-4 C9JP85 NRF1 Nuclear respiratory factor 1 0 20217900.0 5145600.0 7373300.0 7699000.0 False True 7806251.393749137 6057477.007144151 6177289.275408417 1.0 0.7759777006406278 0.7913259468372856 22.89619849362745 -10.103997237415458 5.035975504672222 1.0000066512806638 0.7836518237383121 0.9962395790741925 0.006265895273644913 4.679317680473683e-07 8.326504404301733e-08 0.006067113481576663 0.0020223090033379054 7.870507961769646e-11 10.103997237415458 -0.2163548275423517 VGQQAIVLCISPSKPNPVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGQQAIVLCISPSKPNPVFK 20 1 C9JP85;Q16656-2;Q16656;Q16656-4 C9JP85 NRF1 Nuclear respiratory factor 1 0 8012300.0 1887500.0 2403200.0 3721600.0 False True 2585359.757769564 2297018.6776803336 2842634.72875793 1.0 0.8884715834139897 1.0995122517147562 21.301933617615653 -6.763141251589178 1.6007950030761324 0.9354704794212882 1.100401009029783 0.7035874205718613 0.04693246566277518 0.2776800204517246 1.4031179560569125 0.02312544572713623 0.055399781930532264 1.7252766651825287e-07 6.763141251589178 0.16493052960849486 VGQQAIVLCISPSKPNPVFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGQQAIVLCISPSKPNPVFK 20 1 C9JP85;Q16656-2;Q16656;Q16656-4 C9JP85 NRF1 Nuclear respiratory factor 1 0 14579700.0 5145600.0 6065700.0 3368400.0 False True 6661080.634939885 5728138.462821173 2755385.762702654 1.0 0.8599413183462938 0.41365446745226514 22.667324815719898 -6.950087798170126 0.5578771932969366 1.0059029746663237 0.24644155677099788 0.9992081669258411 0.007035439263304174 0.08345047493862158 0.03581635967170211 0.007561072180868797 0.03708166905562553 1.1217916468838024e-07 6.950087798170126 -0.7594614178953258 down VGSDMTSQQEFTSCLK(ub)ETLSGLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGSDMTSQQEFTSCLKETLSGLAK 24 1 Q5QNY5;P40855;P40855-5 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 57373000.0 17646000.0 17364000.0 22363000.0 True False 17085837.38893206 24297535.752063744 16505459.424380526 1.0 1.4220863279316533 0.9660316347779656 24.026297621212212 -6.663566621185765 1.9605019998862754 1.2708982041489512 0.9679307890354572 0.2507288571485531 0.17956433911492584 0.476067299399115 3.521245027986252 0.07390713635417089 0.19910946004948032 2.1698683181768458e-07 6.663566621185765 -0.302967415113494 VGSDMTSQQEFTSCLK(ub)ETLSGLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGSDMTSQQEFTSCLKETLSGLAK 24 1 Q5QNY5;P40855;P40855-5 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 118060000.0 19040000.0 62807000.0 36213000.0 True False 28885072.01045235 51598600.13666927 29055484.67727827 1.0 1.7863414056228701 1.0058996794871848 24.78382075553119 -10.227656014004143 3.772627101588263 0.999553110153005 1.3961205417871185 0.2556692301955191 0.31861400182524224 226361450.49800438 411891114.8480411 1302470.5929407647 0.11660077537483958 5.920303703326657e-11 10.227656014004143 0.39656743163411357 VGSDMTSQQEFTSCLK(ub)ETLSGLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGSDMTSQQEFTSCLKETLSGLAK 24 1 Q5QNY5;P40855;P40855-5 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 62548000.0 17646000.0 24885000.0 20017000.0 True False 14673430.85034631 24750939.56571424 24202462.151849058 1.0 1.686786125081994 1.6494071767324852 23.806702896646488 -10.145159784210934 4.691904061731885 0.9999348355079989 1.6680966509140935 0.9976578294845692 0.015259891786516152 10669698.172947332 0.93845872693214 7511.535079863743 0.005223866844324784 7.158799775260935e-11 10.145159784210934 0.6681618154060947 VGSDMTSQQEFTSCLK(ub)ETLSGLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGSDMTSQQEFTSCLKETLSGLAK 24 1 Q5QNY5;P40855;P40855-5 Q5QNY5 PEX19 Peroxisomal biogenesis factor 19 1 92145000.0 19040000.0 54899000.0 18206000.0 True False 24647655.33451015 51843822.38990052 14892694.809335155 1.0 2.103397734441375 0.6042235907317037 24.554947077623638 -6.709443686579861 1.7968329864584773 1.6787026660190654 0.6077444536850857 0.46266121284637707 0.4650032601317904 0.3761743509726956 2.367076181178716 0.20595464716441186 0.523644392487614 1.952343871114095e-07 6.709443686579861 -1.0709582123339798 VGSEIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGSEIER 7 0 P52272-2;P52272;A0A087X0X3;M0QZM1 P52272-2;M0QZM1 HNRNPM Heterogeneous nuclear ribonucleoprotein M 0 4818440.0 1776500.0 734840.0 2307100.0 False True 1720105.9799069364 1028265.4441399765 1702801.2984835797 1.0 0.5977919129120225 0.9899397585814491 20.714066024935214 -10.79400113411332 10.08631240573146 1.0017233800507628 0.7938658362102811 0.26922831550844195 0.16009368760363019 0.0062461413372911665 0.00012756868116016844 0.15605649567595442 0.05167001549348271 1.6069370566641445e-11 10.79400113411332 -0.20785754384048172 VGSHITGGDIYGIVSENSLIK(ub)HK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGSHITGGDIYGIVSENSLIKHK 23 1 P38606;P38606-2;C9JVW8;C9JA17 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 19410700.0 3902600.0 4987100.0 10521000.0 True False 3778714.0991752325 6978475.037382936 7765234.476765532 1.0 1.8467856668240936 2.0549939140567486 21.849463936478408 -10.806887572904087 0.2776714598357703 1.2995191734764973e-13 2.1341463708708357 0.9991759858627737 0.013096713052328415 2.5814323266126427 0.14135002690767043 1.7870700743487988 0.08266258912089818 1.559956281053369e-11 10.806887572904087 2.1341463708707056 VGSHITGGDIYGIVSENSLIK(ub)HK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGSHITGGDIYGIVSENSLIKHK 23 1 P38606;P38606-2;C9JVW8;C9JA17 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 98228400.0 9590200.0 8717200.0 79921000.0 True False 14549034.53753362 7161547.552205529 64124579.31938133 1.0 0.4922352430829797 4.407480039582877 23.79442008441546 -6.874297168085786 1.1111807326647531 0.7038612666237312 4.656238243879463 0.9687836757185936 0.30714058719549103 0.13279806763138766 0.3038746455837525 0.21391507793838735 0.510560926775521 1.3356812574714015e-07 6.874297168085786 3.9523769772557324 up VGSHITGGDIYGIVSENSLIK(ub)HK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGSHITGGDIYGIVSENSLIKHK 23 1 P38606;P38606-2;C9JVW8;C9JA17 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 10873800.0 3902600.0 2821700.0 4149500.0 True False 3245184.814494017 2806498.942036399 5017141.264879733 1.0 0.8648194486494857 1.5460263595686756 21.629869211912684 -6.8551334616814765 1.2099783553017727 0.9274055791374362 1.5760913772797387 0.9474564376779793 0.0675016239293213 0.15190106140352805 0.42537072212308225 0.043587622985514614 0.1012585433379798 1.3959393133820365e-07 6.8551334616814765 0.6486857981423025 VGSHITGGDIYGIVSENSLIK(ub)HK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGSHITGGDIYGIVSENSLIKHK 23 1 P38606;P38606-2;C9JVW8;C9JA17 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 65700800.0 9590200.0 6325600.0 49785000.0 True False 12414702.951103952 5973574.799350705 40724640.83723776 1.0 0.48116937013136646 3.2803556394087066 23.56554640650791 -6.858827418170129 1.1915920215486535 0.7193174562837165 3.4129345102724225 0.9522012975936466 0.2658205421346034 0.14801950660745378 0.4000262527325136 0.17406743646651981 0.40581861234256766 1.3841162958532291e-07 6.858827418170129 2.693617053988706 up VGSHPEGGASWLSTAANFLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGSHPEGGASWLSTAANFLSR 21 0 Q9NVT9;Q9NVT9-2 Q9NVT9 ARMC1 Armadillo repeat-containing protein 1 0 4049000.0 730100.0 1538500.0 1780400.0 False True 957168.1702984564 1308961.7970260293 1596181.2868027354 1.0 1.3675358600964336 1.6676079881605623 19.868412896682965 -6.973439334844959 0.1554281383815454 0.6765591050100115 2.366514181865515 0.9999982969903295 0.00035623395939884587 0.07520166438666186 0.004775976798705533 0.01451576096284293 0.03663557726259975 1.0630670692159763e-07 6.973439334844959 1.6899550768555036 VGSHPEGGASWLSTAANFLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGSHPEGGASWLSTAANFLSR 21 0 Q9NVT9;Q9NVT9-2 Q9NVT9 ARMC1 Armadillo repeat-containing protein 1 0 8153400.0 730100.0 2578800.0 4844500.0 False True 1000037.7002106273 2464860.08904879 3700328.875609361 1.0 2.464767166807454 3.7001893776904615 19.931622958205857 -7.119882496163449 0.18043447974106788 9.984564244684392e-13 6.017637103781477 0.9999959556539091 0.0022195393186923654 0.08019802670072236 0.0068467249082239615 0.06055419700547784 0.1571080127807052 7.58782845504847e-08 7.119882496163449 6.017637103780479 VGSK(ub)TEVAECK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGSKTEVAECK 11 1 Q9UKN8;F2Z356 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 4073780.0 1299000.0 1821500.0 953280.0 True False 1703001.5795338957 1549739.3001513877 854643.7301074546 1.0 0.9100046170101291 0.5018455299033645 20.69964834244084 -6.942002203195656 0.6406656301430171 1.0044703182567707 0.3849765971357267 0.9984145705252744 0.008630694304770519 0.08686496636161364 0.05053829253658141 0.008534739691059716 0.03483131134892053 1.1428725369307132e-07 6.942002203195656 -0.6194937211210441 VGSK(ub)TEVAECK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGSKTEVAECK 11 1 Q9UKN8;F2Z356 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 2925120.0 1507800.0 1024800.0 392520.0 True False 1459935.7143279905 1434007.9842614005 289707.2366524098 1.0 0.9822404988026993 0.19843835164054618 20.47747341331844 -6.911784244473404 0.8834922341527166 1.0229212952993947 0.09318076517713442 0.9915774698081979 0.034300124680402 0.10325090942094996 0.13245434092116729 0.0283318635119604 0.07921066858654643 1.225224734178368e-07 6.911784244473404 -0.9297405301222603 down VGSK(ub)TEVAECK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGSKTEVAECK 11 1 Q9UKN8;F2Z356 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 20732890.0 5677800.0 3112090.0 11943000.0 True False 8613637.702780798 2556713.2246298515 9582460.815197151 1.0 0.2968215419374384 1.1124754889683346 23.0381912131508 -6.678565042255562 1.906613607376686 0.5545351073565985 1.109367052762593 0.31776644337151827 0.29811482016242524 0.44169870059612293 3.1030121866385594 0.12551033216873098 0.33168006687719853 2.096210817081418e-07 6.678565042255562 0.5548319454059945 VGSK(ub)TEVAECK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGSKTEVAECK 11 1 Q9UKN8;F2Z356 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 4683600.0 1299000.0 2198700.0 1185900.0 True False 1779275.4041550572 2101554.1638714024 905814.844377157 1.0 1.181129216401094 0.5090919833218909 20.762858403963733 -6.834935576572746 1.3055802948292734 1.0965068359471295 0.4890974390000113 0.9154123912552835 0.08257158618318694 0.1747977215135617 0.58092149994337 0.049628217583562936 0.1142326713753864 1.4623940905259348e-07 6.834935576572746 -0.6074093969471182 VGSK(ub)TEVAECK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGSKTEVAECK 11 1 Q9UKN8;F2Z356 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 3203520.0 1507800.0 992390.0 703330.0 True False 1253802.5068656995 987043.7980960072 850393.0511695065 1.0 0.7872402493144273 0.6782511970687868 20.257878688752715 -13.999999999987006 0.0856195546942586 2.1120568088950424 0.38410152711762147 0.9998624824139102 0.0015668199542960635 12.204097504077948 0.0839164544932189 2.5100343904286806 0.2654208831020087 1.0000000000299199e-14 13.999999999987006 -1.727955281777421 VGSK(ub)TEVAECK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGSKTEVAECK 11 1 Q9UKN8;F2Z356 Q9UKN8 GTF3C4 General transcription factor 3C polypeptide 4 1 13862330.0 5677800.0 3217830.0 4966700.0 True False 7350024.026170262 3038754.9318000977 4062811.562645556 1.0 0.41343469367996666 0.5527616710067393 22.80931753524325 -10.115288457388015 7.771549958360976 1.0000000688379724 0.483098182343704 0.9483258695042796 0.05688000030915235 6.79067024746303e-08 7.708691672102534e-09 0.055073830868295925 0.018357941160801656 7.668519788662062e-11 10.115288457388015 -0.5169018864942685 VGSLIFHTIGQLLPQQMQAFHSPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGSLIFHTIGQLLPQQMQAFHSPK 24 0 Q8NEZ4;Q8NEZ4-3;H0Y765;H7BY37;Q8NEZ4-2 Q8NEZ4 KMT2C Histone-lysine N-methyltransferase 2C 0 15671200.0 8478800.0 1651900.0 5540500.0 False True 8209645.135060463 2311512.2845446975 4089276.8385628196 1.0 0.28156056035516736 0.4981064067067867 22.968888431649646 -10.04165402282948 5.150046985993338 1.00000707817931 0.38983348352926883 0.9136896381346382 0.0884044715877156 244726648.8526627 78.89230224022054 20541.388062728907 0.03026320204440204 9.085440261731733e-11 10.04165402282948 -0.6101735946500412 VGSLIFHTIGQLLPQQMQAFHSPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGSLIFHTIGQLLPQQMQAFHSPK 24 0 Q8NEZ4;Q8NEZ4-3;H0Y765;H7BY37;Q8NEZ4-2 Q8NEZ4 KMT2C Histone-lysine N-methyltransferase 2C 0 92108000.0 29623000.0 30784000.0 31701000.0 False True 44940256.73138822 25290354.683510195 25435283.454958085 1.0 0.5627550112735853 0.5659799321349445 25.421505030474854 -10.184859783473817 5.35476022925972 1.0000188035133648 0.5643674734370483 0.9999588992935213 0.001316568428887236 2.9555820674849177e-07 4.4991903370974413e-08 0.0012748168417855814 0.0004249206332175533 6.533414567376158e-11 10.184859783473817 -0.4356513300763165 VGSLIFHTIGQLLPQQMQAFHSPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGSLIFHTIGQLLPQQMQAFHSPK 24 0 Q8NEZ4;Q8NEZ4-3;H0Y765;H7BY37;Q8NEZ4-2 Q8NEZ4 KMT2C Histone-lysine N-methyltransferase 2C 0 48012200.0 29623000.0 10476000.0 7913200.0 False True 38347557.45662793 9893001.390855884 6473078.796288632 1.0 0.2579825690865741 0.16880028939548106 25.192631352567304 -13.999999999999998 0.29888977257093685 7.725440195458127 0.14660355601080274 0.9996473530232021 0.006996901187210451 16.51644912391856 0.1735941695378288 68.6523062209053 0.03238448875596211 1.0000000000000041e-14 13.999999999999998 -7.578836639447324 VGSLLGDREK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGSLLGDREK 10 1 A0A1W2PP28;A0A1W2PRE6;A0A1X7SBU8;A0A1W2PRV0;O14653-3 A0A1W2PP28 GOSR2 Golgi SNAP receptor complex member 2 1 16192150.0 1945100.0 941050.0 13306000.0 True False 2550044.9363751956 800649.0081841695 11929222.760164687 1.0 0.3139744703174782 4.678044135614991 21.28209123951201 -6.866703541740473 1.1513192092533209 0.6187246385609656 4.918187415113429 0.9612848771141747 0.37701939222150394 0.14005870957780334 0.34904144841707113 0.2546061319052533 0.5996049318550494 1.3592409755524574e-07 6.866703541740473 4.299462776552463 up VGSLLGDREK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGSLLGDREK 10 1 A0A1W2PP28;A0A1W2PRE6;A0A1X7SBU8;A0A1W2PRV0;O14653-3 A0A1W2PP28 GOSR2 Golgi SNAP receptor complex member 2 1 2838470.0 1945100.0 365950.0 527420.0 True False 2664256.0343510397 349781.11896517896 402854.25855586474 1.0 0.1312866010080667 0.1512070361713536 21.3453013010349 -10.51591416774874 4.432340193085345 1.0061409457857613 0.1412468185890216 0.9995965895230778 0.008132483603199825 0.0004950695391833491 5.4069858106876477e-05 0.007899176527833927 0.0026247477961926246 3.048497423121215e-11 10.51591416774874 -0.8648941271967396 VGSLNCIVAVSQNMGIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGSLNCIVAVSQNMGIGK 18 0 P00374;B4DM58 P00374 DHFR Dihydrofolate reductase 0 15024700.0 3134000.0 7297400.0 4593300.0 False True 4108704.3496991717 6208656.365042405 4118029.3780448306 1.0 1.511098350383129 1.002269578814144 21.97025209146554 -10.75233380948094 3.8441455446935713 0.9713362000145546 1.2566839645962211 0.2533452320426981 0.207728476134927 0.05331479749182055 0.003434903027072541 0.21013488673953093 0.06704407738322021 1.7687489315309957e-11 10.75233380948094 0.28534776458166655 VGSLNCIVAVSQNMGIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGSLNCIVAVSQNMGIGK 18 0 P00374;B4DM58 P00374 DHFR Dihydrofolate reductase 0 10306600.0 4759400.0 2231200.0 3316000.0 False True 4608315.452163849 3122129.795554287 2447440.122132353 1.0 0.6774991486505727 0.5310921414859198 22.135808046020976 -13.99999999999879 0.10639959366854224 2.567048814542705 0.2480372408422417 0.9997613659881895 0.003025887119047334 12.03499112466658 0.09837393880156413 4.080296652282536 0.2516894150817165 1.0000000000027855e-14 13.99999999999879 -2.3190115737004633 VGSLNCIVAVSQNMGIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGSLNCIVAVSQNMGIGK 18 0 P00374;B4DM58 P00374 DHFR Dihydrofolate reductase 0 17272500.0 3134000.0 4863200.0 9275300.0 False True 4292724.493165469 4648327.7435481865 7084665.170799777 1.0 1.0828385914234377 1.650388973734376 22.03346215298843 -6.933096325142201 0.7209207927311874 0.9922824653290052 1.7766580236489118 0.9971126342144844 0.01553220780771338 0.09106147173582739 0.07003486560801009 0.014420886600463305 0.05050759921141679 1.1665508510768849e-07 6.933096325142201 0.7843755583199066 VGSPQPSSSGGEK(ub)RR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGSPQPSSSGGEKRR 15 2 V9GYB6;O94761 V9GYB6 RECQL4 ATP-dependent DNA helicase Q4 1 30364400.0 7074300.0 5096100.0 18194000.0 True False 9274475.80761865 4335781.744442212 16311459.409171553 1.0 0.46749615119816507 1.7587473133276463 23.144834312392362 -6.7947259567918215 1.4774354380315453 0.7041992751485806 1.7743169606475029 0.8162554398266364 0.2271188357499451 0.2283820415807274 0.9846596086782108 0.12096980331718571 0.2822719964651899 1.6042573702964187e-07 6.7947259567918215 1.0701176854989223 VGSPQPSSSGGEK(ub)RR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGSPQPSSSGGEKRR 15 2 V9GYB6;O94761 V9GYB6 RECQL4 ATP-dependent DNA helicase Q4 1 19279800.0 7074300.0 4315100.0 7890400.0 True False 9689859.885769136 4124444.613872505 6026850.027888962 1.0 0.42564543373117364 0.621974940704788 23.208044373915254 -10.20155059772957 4.916168013674998 1.0000565545894415 0.5238101872171406 0.8869267278972368 0.08015118559251236 4.9688747999135e-05 8.070115294407443e-06 0.07761523581950362 0.02586868391446486 6.287086017920275e-11 10.20155059772957 -0.47624636737230097 VGSTSENITQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGSTSENITQK 11 0 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 7201630.0 2346700.0 761530.0 4093400.0 False True 2272205.293018635 1065612.9003264878 3021215.740632257 1.0 0.46897738668270433 1.3296403057923338 21.115661757089235 -6.739801179026294 1.6874957070228067 0.6839682462431702 1.3301153542777695 0.6040096281230969 0.22311405055546296 0.31818093302481637 1.7790035357305778 0.10460080585460557 0.2567299252104346 1.820534112403173e-07 6.739801179026294 0.6461471080345993 VGSTSENITQK(ub)VVWVEESDKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGSTSENITQKVVWVEESDKR 21 2 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 1 21414200.0 6515400.0 9392400.0 5506400.0 True False 8541752.495223355 7991090.531288449 4936650.54911851 1.0 0.9355329056604201 0.5779435252753041 23.02610066455463 -6.9375195736235415 0.6822534185308008 1.0042380255391372 0.488166345297301 0.9978205544145539 0.008666486112316709 0.08891685869513102 0.05990179733285715 0.008285289091673321 0.031128312289118918 1.1547299399147109e-07 6.9375195736235415 -0.5160716802418361 VGSTSENITQK(ub)VVWVEESDKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGSTSENITQKVVWVEESDKR 21 2 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 1 18841800.0 5598100.0 6172600.0 7071100.0 True False 5420391.379745017 8637351.369683754 5218966.781547067 1.0 1.5934921972534883 0.9628394733725989 22.369965594562316 -6.65987637612341 1.9734416814752582 1.3820635286742133 0.9654749586363431 0.23505715425639917 0.25270309157215703 0.48472021904395335 3.6287960711039813 0.10346311496209601 0.28011027562813123 2.1883844687741996e-07 6.65987637612341 -0.4165885700378702 VGSTSENITQK(ub)VVWVEESDKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGSTSENITQKVVWVEESDKR 21 2 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 1 17599500.0 6515400.0 6237000.0 4847100.0 True False 8924319.452064553 5961428.716999098 3702314.8091580435 1.0 0.6679981312883169 0.4148568223094647 23.08931072607752 -7.633441264336977 0.18181614048808237 1.2440286708059107 4.048655180822206e-16 0.9999505691455781 0.0016845882628552739 0.13377614713928188 0.020502285585788014 0.04556102464379241 0.0783827497520706 2.32572700490686e-08 7.633441264336977 -1.2440286708059103 down VGSTSENITQK(ub)VVWVEESDKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGSTSENITQKVVWVEESDKR 21 2 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 1 17774000.0 5598100.0 7084100.0 5091800.0 True False 4655068.1878796145 7045936.547216242 6156471.8381768055 1.0 1.5136054431085937 1.32253096833391 22.150370869996593 -10.104320032111325 4.484252470417639 0.9999611949226026 1.418068205707674 0.8645544650973831 0.07800582774502432 54322022.36441328 1.2952553773111934 22577.28680268031 0.02670346966048884 7.864660283723944e-11 10.104320032111325 0.4181070107850713 VGSTSENITQK(ub)VVWVEESDKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGSTSENITQKVVWVEESDKR 21 2 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3 A0A2R8YCW1 DDX3X ATP-dependent RNA helicase DDX3X 1 67817700.0 8252700.0 16139000.0 43426000.0 True False 10683282.8350374 15240850.462678803 35522913.58838782 1.0 1.4266074106635265 3.325093432131666 23.348851700944696 -6.942433104465125 0.6365245758711702 0.9792580920232987 3.875911415742035 0.9984655509133644 0.03958832587959416 0.0866739436339005 0.049684828810788235 0.039287816205778724 0.16172862916010824 1.1417391561958984e-07 6.942433104465125 2.896653323718736 up VGTAQLALVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGTAQLALVAR 11 0 A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2 A0A087WTA5 EIF2B4 Translation initiation factor eIF-2B subunit delta 0 9576600.0 2589500.0 2837400.0 4149700.0 False True 3394859.576753672 2414070.9800985744 3720328.850733159 1.0 0.7110959748170277 1.0958712036892897 21.694920470123808 -6.705802803778845 1.8102639237169036 0.8216287628817407 1.094855663822159 0.4450799443706899 0.12182598731780073 0.3835883480312135 2.4476915905791654 0.05360982928320699 0.13688686910410136 1.9687800331710508e-07 6.705802803778845 0.27322690094041824 VGTAQLALVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGTAQLALVAR 11 0 A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2 A0A087WTA5 EIF2B4 Translation initiation factor eIF-2B subunit delta 0 6024930.0 1469800.0 766230.0 3788900.0 False True 1423142.0035278427 1072189.6348366635 2796473.4254364497 1.0 0.7533960997418392 1.9649995703199261 20.440648192934205 -6.85369562242014 1.2170887632347318 0.8678611797295387 2.0170106798633505 0.9455185307567953 0.12203166150837616 0.15343639063493705 0.4355155916597772 0.07837569043365039 0.18185160918052345 1.4005685745523506e-07 6.85369562242014 1.1491495001338117 VGTAQLALVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGTAQLALVAR 11 0 A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2 A0A087WTA5 EIF2B4 Translation initiation factor eIF-2B subunit delta 0 6087500.0 2589500.0 1358700.0 2139300.0 False True 3546908.128606249 1298668.1413799399 1634041.4002665076 1.0 0.3661409019607872 0.46069459400083224 21.7581305316467 -10.784494602945735 7.174258654979216 1.0166815906013227 0.4134177479808097 0.9808848182571204 0.038601383132394966 0.009844666040266521 0.00029572060698187093 0.03572483779230822 0.012458542834361461 1.6425000711864207e-11 10.784494602945735 -0.603263842620513 VGTAQLALVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGTAQLALVAR 11 0 A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2 A0A087WTA5 EIF2B4 Translation initiation factor eIF-2B subunit delta 0 3368510.0 1469800.0 1099100.0 799610.0 False True 1222203.8231802664 1093178.9301457314 966804.754021084 1.0 0.8944325892396552 0.7910339795087412 20.22105346836848 -6.971380501787611 0.222770008636326 1.046046053039689 0.636491398778034 0.9999912337897512 0.00025252263132621996 0.07585730998713337 0.007407034954098286 0.0028042767868271027 0.010419387493110811 1.0681186500852822e-07 6.971380501787611 -0.40955465426165494 VGTASVLQPVK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGTASVLQPVKK 12 1 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 1 10235300.0 1885200.0 3531400.0 4818700.0 True False 1825355.35790631 4941506.436007711 3556537.9120986634 1.0 2.7071476327084274 1.9484085094411572 20.799745922731983 -10.127830734116968 4.652171756686394 0.9998851492965543 2.3277780710933 0.8032750240704212 0.30975395005147005 108104825.25201201 31.44068343149827 134697.94280524747 0.1060370160642613 7.450222890931989e-11 10.127830734116968 1.327892921796746 VGTASVLQPVK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGTASVLQPVKK 12 1 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 1 9372100.0 1885200.0 5178800.0 2308100.0 True False 1567627.328520508 5150900.776488685 2790713.0385513725 1.0 3.2857941953270178 1.7802145878543632 20.58015119816626 -10.28186761506457 6.172761604877598 0.9999434174333702 2.533004391590692 0.5802464347009311 0.6146503009079702 0.0004786401484698107 5.568331301934061e-05 0.5951541719483177 0.19837753159649482 5.2255545403757186e-11 10.28186761506457 1.5330609741573218 VGTSFSIPVVSDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGTSFSIPVVSDVR 14 0 Q92979;V9GYP5;A0A087WWQ2 Q92979 EMG1 Ribosomal RNA small subunit methyltransferase NEP1 0 15108000.0 4331800.0 3757400.0 7018800.0 False True 5933383.522493352 3591385.643939785 5361103.996723498 1.0 0.60528459526085 0.9035492103956617 22.50042360816734 -10.260941405517647 7.360112784671879 1.0000008925731436 0.7544169028282577 0.4747691204944192 0.12176601923464893 1.7834000796837675e-06 1.7926292761177784e-07 0.11789986980006764 0.03929981371914728 5.483509427713276e-11 10.260941405517647 -0.24558398974488593 VGTVIGSNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGTVIGSNK 9 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 8038350.0 450150.0 4465600.0 3122600.0 False True 590151.0092588014 3799349.8867724654 2799503.306094263 1.0 6.437928305069323 4.74370671603238 19.170724636425042 -9.783831181623245 7.498904347830164 0.9999999965172492 5.590817510550873 0.9073207577423003 0.6916630673913803 3.6719257022873084e-08 5.323074200728917e-09 0.6696998852983514 0.22323329509945114 1.6450110454670902e-10 9.783831181623245 4.590817514033624 VGTVIGSNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGTVIGSNK 9 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 4216120.0 1196700.0 646020.0 2373400.0 False True 1158711.4135404606 903979.1549497957 1751735.339526215 1.0 0.7801590149074941 1.5117960512477915 20.144089865524947 -6.826135930093542 1.3449943923691488 0.8821791872080759 1.5299865498404777 0.8979354607243795 0.09792371658363039 0.18563250662473885 0.658087177774834 0.05718431287737058 0.13164402887783722 1.4923272520622704e-07 6.826135930093542 0.6478073626324018 VGTVIGSNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGTVIGSNK 9 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 6455950.0 450150.0 2788500.0 3217300.0 False True 616582.6198463424 2665294.849663621 2457440.0023734095 1.0 4.322688904737268 3.985581045060635 19.233934697947934 -10.183282901605013 4.640856358572514 0.9994887733223379 4.15413497492672 0.991505581841693 0.13762370750988423 24146981.84102879 126.83293662911375 131913.8301926416 0.0471122556424353 6.557179891639242e-11 10.183282901605013 3.1546462016043817 VGTVIGSNK(ub)LEQMPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGTVIGSNKLEQMPSK 16 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 5892900.0 1682600.0 2289300.0 1921000.0 True False 1629186.7840086736 3203429.428541789 1417832.4712353002 1.0 1.9662751134401137 0.8702700544542054 20.63572058565852 -6.673909064691022 1.9232755909346049 1.6146698868225757 0.8745901810479133 0.29660843220669697 0.41008386235361144 0.452186706010866 3.228225318906599 0.17142037864413748 0.4557105021105222 2.1188047374613688e-07 6.673909064691022 -0.7400797057746624 VGTVIGSNK(ub)LEQMPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGTVIGSNKLEQMPSK 16 1 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 6230700.0 1682600.0 2955600.0 1592500.0 True False 1399156.4518186941 2939677.5961593315 1925484.387111935 1.0 2.1010356578338256 1.3761751837037905 20.416125861092798 -10.157551120628376 4.8729736194476345 0.9999420337396439 1.738605420771481 0.580603518234965 0.2959230493976522 0.00018637585051632066 3.222109342120155e-05 0.2865486211091781 0.09550875350501861 6.957430542460428e-11 10.157551120628376 0.7386633870318371 VGTYCIQFGFMMDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGTYCIQFGFMMDK 14 0 A6NHR9-2;A6NHR9;J3KTL8;A6NHR9-3;A0A2R8YE92 A6NHR9-2 SMCHD1 Structural maintenance of chromosomes flexible hinge domain-containing protein 1 0 18672900.0 6327300.0 5003700.0 7341900.0 False True 9598976.687591149 4110750.640913461 5890770.246930911 1.0 0.4282488409652601 0.6136873167476348 23.194449182821746 -10.213109214781662 6.057967840994408 1.000008192291237 0.520968078856448 0.8989643741250454 0.07570494072438658 8.376547597799425e-06 1.0881659329532309e-06 0.07330224553535057 0.02443366455426296 6.121964194576987e-11 10.213109214781662 -0.4790401134347889 VGTYQLAIVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGTYQLAIVAK 11 0 Q9BV20;Q9BV20-2 Q9BV20 MRI1 Methylthioribose-1-phosphate isomerase 0 14104300.0 4235300.0 4936700.0 4932300.0 False True 5552519.31470354 4200163.6031058775 4421952.909962446 1.0 0.7564428622487616 0.7963867677601304 22.40471107558874 -10.157085498294459 5.077035683528551 1.0000117472445933 0.7764148150041853 0.9766222380631909 0.016307031140486844 2.1684376493213325e-06 3.60018885690164e-07 0.01579004432708111 0.0052630716692862525 6.9648938476891e-11 10.157085498294459 -0.223596932240408 VGTYQLAIVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGTYQLAIVAK 11 0 Q9BV20;Q9BV20-2 Q9BV20 MRI1 Methylthioribose-1-phosphate isomerase 0 12081900.0 3409500.0 2093100.0 6579300.0 False True 3301267.288765941 2928885.7453723038 4855983.955230824 1.0 0.8872004261330689 1.4709454068610293 21.654588521142994 -6.856605476058025 1.2026990665894828 0.939266658689266 1.4974434873764526 0.9493851567724132 0.05687928508551778 0.1503421312005305 0.4151667855608549 0.036932597524260403 0.08591235132304614 1.3912158725526596e-07 6.856605476058025 0.5581768286871867 VGTYQLAIVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGTYQLAIVAK 11 0 Q9BV20;Q9BV20-2 Q9BV20 MRI1 Methylthioribose-1-phosphate isomerase 0 26763900.0 5912900.0 10846000.0 10005000.0 False True 8970301.590893064 8910446.559815222 8027507.364652715 1.0 0.9933274226656317 0.8948982688388645 23.096725060195734 -6.920630466139444 0.8200366853298907 1.002122826936795 0.8787931720187605 0.9943542335260004 0.003610389129984275 0.09780236079793692 0.10370234798270203 0.0031211427868310182 0.009406412520367176 1.2005203712484874e-07 6.920630466139444 -0.12332965491803449 VGTYQLAIVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGTYQLAIVAK 11 0 Q9BV20;Q9BV20-2 Q9BV20 MRI1 Methylthioribose-1-phosphate isomerase 0 12104500.0 4235300.0 3491800.0 4377400.0 False True 5801204.864678909 3337520.730161536 3343548.275382891 1.0 0.5753150954006628 0.5763541114950701 22.46792113711163 -10.508147655682684 9.172489028831006 1.0000130624609094 0.5758346034478665 0.9999954989500007 0.00042417654430620505 1.133118322831498e-07 6.07602517769647e-09 0.00041071979195086424 0.000136902390995817 3.103504249028517e-11 10.508147655682684 -0.42417845901304285 VGTYQLAIVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGTYQLAIVAK 11 0 Q9BV20;Q9BV20-2 Q9BV20 MRI1 Methylthioribose-1-phosphate isomerase 0 5198100.0 3409500.0 1788600.0 0.0 False True 2835150.3164601433 1778964.4567906978 0.0 1.0 0.627467420849785 0.0 21.43499379657727 -7.5856816605869435 0.6830450430062364 0.9959367618114471 7.78614770838508e-21 0.9871002430812368 0.04686721683179834 0.12107003223908912 0.14594676048136337 0.04223998499987363 0.07694408594424604 2.5960816019857623e-08 7.5856816605869435 -0.9959367618114471 down VGTYQLAIVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGTYQLAIVAK 11 0 Q9BV20;Q9BV20-2 Q9BV20 MRI1 Methylthioribose-1-phosphate isomerase 0 23713100.0 5912900.0 11352000.0 6448200.0 False True 7654365.610684101 10720251.22079001 5274693.7641192395 1.0 1.4005407849641376 0.6891092002133694 22.867851382288183 -6.753945677645397 1.6352056982241165 1.2344011925468379 0.6872559874887936 0.6657757590900993 0.1683537706918361 0.29321856152369224 1.5437149769729355 0.08129036163888419 0.19654332835744504 1.762196451408509e-07 6.753945677645397 -0.5471452050580443 VGVEVPDVNIEGPEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGVEVPDVNIEGPEGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 15333400.0 7914900.0 2424400.0 4994100.0 False True 7663645.831897227 3392475.563078976 3685995.3902114597 1.0 0.44267123474821746 0.4809715207440566 22.869599459159748 -9.934404278241779 5.925787614644075 1.0000002608752259 0.4618213796050741 0.9962158710453058 0.01563602628283524 5.391026367437694e-08 9.669860379768425e-09 0.015139524792723144 0.005046505782746204 1.1630428661184497e-10 9.934404278241779 -0.5381788812701518 VGVIGFPNVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGVIGFPNVGK 11 0 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 10571700.0 2257900.0 3488900.0 4824900.0 False True 2960128.765534701 2968369.7196256868 4325665.631708896 1.0 1.0027839850032663 1.461309954510554 21.497228503745227 -6.908231816789174 0.9076885727820764 0.9849968812330575 1.5183796604233712 0.9902370222259718 0.021422552526507436 0.1055992210859863 0.1451947669341779 0.017386985948191328 0.04742801229933571 1.23528788808094e-07 6.908231816789174 0.5333827791903137 VGVIGFPNVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGVIGFPNVGK 11 0 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 12400400.0 3789800.0 1195600.0 7415000.0 False True 3669494.8734316393 1673009.3149716337 5472789.054768212 1.0 0.45592360057096043 1.4914284509274072 21.807150050989197 -6.763924173734814 1.5975061501057544 0.6855164641342636 1.4959882455159037 0.7068412286685071 0.22898919257721823 0.27638022366121184 1.3909173150263148 0.11304769165699023 0.2706503226420871 1.7221692333346408e-07 6.763924173734814 0.8104717813816401 VGVIGFPNVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGVIGFPNVGK 11 0 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 9310200.0 2257900.0 2606400.0 4445900.0 False True 3092706.647453192 2491240.6297877943 3395869.9861846757 1.0 0.8055211546944816 1.09802524884833 21.560438565268118 -6.727442457444994 1.7323109206967848 0.8826336317534447 1.0977795661240404 0.547483661027079 0.08177202312248252 0.3410507475645758 2.003800082795651 0.037423732420905964 0.09314322524827862 1.8730852440582952e-07 6.727442457444994 0.2151459343705957 VGVIGFPNVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGVIGFPNVGK 11 0 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 0 7203400.0 3789800.0 877200.0 2536400.0 False True 3151386.616606734 872474.3494894317 3066749.513011441 1.0 0.27685411396107 0.9731429006046785 21.587555326423473 -9.570434696025906 11.167066911350515 0.9999999998847905 0.6249985072828743 0.27888745446740226 0.28425870681641063 0.0 0.0 0.27523230937860377 0.09174410312620124 2.688842128366279e-10 9.570434696025906 -0.3750014926019162 VGVIGFPNVGK(ub)SSIINSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGVIGFPNVGKSSIINSLK 19 1 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 1 12370000.0 2929700.0 7004600.0 2435700.0 True False 2836698.2771367035 9801573.308506455 1797717.1005662766 1.0 3.455275235828018 0.6337357466092058 21.435781277135032 -6.676657118406713 1.9135647683748462 2.558108935590847 0.6446895720382618 0.3089517030480271 1.0413718185872631 0.4460095903417825 3.1545302197588105 0.4371247166737983 1.1579326980077074 2.1054400582422553e-07 6.676657118406713 -1.9134193635525851 VGVIGFPNVGK(ub)SSIINSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGVIGFPNVGKSSIINSLK 19 1 Q9BVP2-2;Q9BVP2 Q9BVP2-2 GNL3 Guanine nucleotide-binding protein-like 3 1 8452400.0 2929700.0 3747000.0 1775700.0 True False 2436175.3577161734 3726814.167278737 2146990.6600908395 1.0 1.529780750582951 0.881295614985436 21.216186552569308 -6.689552506106423 1.8681846991696196 1.3322868451643184 0.8835618797148422 0.3682101083089995 0.22408179106462317 0.41765430099052187 2.825846607409832 0.09597166828006028 0.25004146959788814 2.0438428209214056e-07 6.689552506106423 -0.44872496544947615 VGVK(ub)PVGSDPDFQPELSGAGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGVKPVGSDPDFQPELSGAGSR 22 1 O43396;K7EPB7;K7EKG2 O43396 TXNL1 Thioredoxin-like protein 1 1 11646500.0 2317100.0 4155700.0 5173700.0 True False 3037740.5388283213 3535685.7587917224 4638375.153634759 1.0 1.1639196019537146 1.5269161715252395 21.534567220161147 -6.95800468309372 0.4626978192370036 0.9896995875837928 1.7158356593751014 0.9996888856255446 0.003883464703874179 0.08042173857437912 0.02382432661101785 0.004952902984321475 0.029978739499621668 1.101527431462773e-07 6.95800468309372 0.7261360717913086 VGVK(ub)PVGSDPDFQPELSGAGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGVKPVGSDPDFQPELSGAGSR 22 1 O43396;K7EPB7;K7EKG2 O43396 TXNL1 Thioredoxin-like protein 1 1 13820400.0 3282500.0 4995500.0 5542400.0 True False 3178298.8342496594 6990229.20118835 4090679.17156404 1.0 2.1993618491316664 1.2870656237489315 21.59982334738424 -10.374986771911662 5.0693033054884395 0.9994956499104837 1.7432137364403786 0.46946801463688725 0.37244337440941383 0.002124328603635388 0.0002619160138124118 0.36084877861240955 0.12020558220770629 4.2170934799324037e-11 10.374986771911662 0.7437180865298949 VGVK(ub)PVGSDPDFQPELSGAGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGVKPVGSDPDFQPELSGAGSR 22 1 O43396;K7EPB7;K7EKG2 O43396 TXNL1 Thioredoxin-like protein 1 1 43390500.0 7048500.0 13886000.0 22456000.0 True False 10693089.814373618 11407934.8081868 18017561.757185563 1.0 1.0668511165830001 1.6849724513644702 23.350175450458156 -6.92750554486506 0.7669806321210244 0.9896802908670663 1.804172389045559 0.996025197437992 0.019440389660435962 0.09395323153761191 0.08417479686649318 0.017455306640858342 0.056715449309854546 1.1816652255097832e-07 6.92750554486506 0.8144920981784927 VGVK(ub)PVGSDPDFQPELSGAGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGVKPVGSDPDFQPELSGAGSR 22 1 O43396;K7EPB7;K7EKG2 O43396 TXNL1 Thioredoxin-like protein 1 1 12735900.0 2317100.0 6080900.0 4337900.0 True False 3173794.487273043 5812225.731152774 3313377.361854852 1.0 1.8313176087676357 1.0439798087562187 21.59777728168404 -10.366420672855435 4.171981493736101 0.9990049511916776 1.437648708769109 0.29177072235913126 0.3214293108962488 0.0029813966679590608 0.0004527706637961183 0.31190113226536936 0.10374086400369051 4.301097892350023e-11 10.366420672855435 0.43864375757743135 VGVK(ub)PVGSDPDFQPELSGAGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGVKPVGSDPDFQPELSGAGSR 22 1 O43396;K7EPB7;K7EKG2 O43396 TXNL1 Thioredoxin-like protein 1 1 12836600.0 3282500.0 4874700.0 4679400.0 True False 2729544.189406198 4848439.023547805 5657840.904898959 1.0 1.7762815646529484 2.0728152806091047 21.380228622818517 -10.457124943213469 0.20862055126244403 3.99732705740059e-17 2.3019493107925886 0.9993410565096075 0.011611438807187704 2.1491663220898656 0.1050830944788221 1.29623930740324 0.1717442355156136 3.49039884917238e-11 10.457124943213469 2.3019493107925886 VGVNGFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VGVNGFGR 8 0 P04406 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 101582000.0 10849000.0 50702000.0 40031000.0 False True 14223144.061865455 43137459.23484808 35888976.1244666 1.0 3.032906019036014 2.523280082685145 23.761737075799388 -10.19766172844224 4.946093503097799 0.9998087883397556 2.77809305086341 0.9419649853004627 0.20805391730108458 0.0004387315062960645 7.116948657005127e-05 0.20146802208846706 0.06714911306696039 6.343636240996424e-11 10.19766172844224 1.7782842625236546 VGVNGFGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VGVNGFGR 8 0 P04406 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 125950000.0 34318000.0 12821000.0 78811000.0 False True 33228593.874723475 17940492.160631754 58168034.82067933 1.0 0.5399112652274712 1.750541567903267 24.98592190840354 -6.803730828361875 1.4407596314288096 0.7473382450974566 1.76880975729231 0.8428138868012482 0.19781988206257717 0.21547527373048372 0.8826319784225395 0.10799942803276871 0.25060365536130735 1.5713364021226852e-07 6.803730828361875 1.0214715121948534 VGVNGFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VGVNGFGR 8 0 P04406 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 116825000.0 10849000.0 52373000.0 53603000.0 False True 14860168.483201083 50058987.68564918 40943075.388438106 1.0 3.368668918003128 2.7552228250119013 23.82494713732228 -10.188784041580087 5.273107933725773 0.9998911952252885 3.061945871508206 0.9377490228649086 0.2504383187578227 0.0003203613194355213 4.928313858379707e-05 0.24249821807630254 0.08082861981642057 6.474644956158937e-11 10.188784041580087 2.0620546762829175 VGVNGFGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VGVNGFGR 8 0 P04406 P04406 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 43451400.0 34318000.0 5828900.0 3304500.0 False True 28536937.54517651 5797498.558753931 3995455.671718304 1.0 0.20315769866952174 0.14000996657027903 24.766327183837817 -13.814363046501375 0.36100612345918315 9.999999999999972 0.13244311735639808 0.9997701468878278 0.00593350828244861 18.999997931921744 0.19388786714178832 131.0479619498332 0.01817085669686323 1.533334662745904e-14 13.814363046501375 -9.867556882643573 VGWSTMQASLDLGTDKFGFGFGGTGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VGWSTMQASLDLGTDKFGFGFGGTGK 26 1 Q92499;F1T0B3;A0A087X2G1;Q92499-3;Q92499-2 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 57962000.0 14522000.0 17862000.0 25578000.0 False True 22030935.70040908 14674386.543557014 20522497.088764366 1.0 0.6660809483132636 0.9315308876501007 24.393027434859608 -9.886493275937514 6.106017466350216 1.0000000319538878 0.7988059179816124 0.43373450763148846 0.10836948393824856 4.712885461731511e-08 8.706302895981677e-09 0.1049283188314423 0.03497610054412426 1.2986936709918293e-10 9.886493275937514 -0.20119411397227538 VGYFGPTQFYIALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VGYFGPTQFYIALK 14 0 Q8NFH8-4;Q8NFH8 Q8NFH8-4 REPS2 RalBP1-associated Eps domain-containing protein 2 0 14312000.0 4755800.0 3695800.0 5860400.0 False True 6156476.850833164 3490125.481130698 4793867.332781925 1.0 0.5669030462866721 0.7786705690500834 22.553673549477775 -10.14231845273204 5.014211643352092 1.0000163769765922 0.6727868076676805 0.7609559721459505 0.08645372914634941 1.582864990422939e-05 2.70744071628635e-06 0.08371265023130485 0.02790282109976517 7.205789104719329e-11 10.14231845273204 -0.32722956930891167 VHAPGLNLSGVGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHAPGLNLSGVGGK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 8936500.0 1355200.0 2941500.0 4639800.0 False True 1776680.3237754665 2502639.665877197 4159718.004104321 1.0 1.4086043687133645 2.3412866954393188 20.760752691437794 -6.957380690634854 0.4709042634544969 0.9755805103638521 2.8126038809808573 0.9996603594150992 0.010345088706698237 0.08065049315792107 0.02469225651938346 0.012917857487151265 0.07697446820012668 1.1031112389085267e-07 6.957380690634854 1.8370233706170054 up VHAPGLNLSGVGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHAPGLNLSGVGGK 14 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9826900.0 1355200.0 4719900.0 3751800.0 False True 1856254.0629029477 4511359.2113779215 2865702.110746455 1.0 2.43035654522567 1.5438092058717747 20.823962752960686 -10.252408610716262 5.569086430494117 0.9999322486454193 1.9870828755487278 0.6230515993334922 0.3619314357066292 0.0003045050243074953 4.087655849786291e-05 0.3504623904064562 0.11681286858004289 5.592311951061365e-11 10.252408610716262 0.9871506269033085 VHAVIGVLMDDTDPLVTVMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHAVIGVLMDDTDPLVTVMK 20 0 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 0 15521900.0 3250500.0 7195100.0 5076300.0 False True 4931246.143381064 5911078.189427111 4072967.0799786733 1.0 1.1986986691713253 0.8259508776388276 22.233520836150714 -6.761910144685191 1.6054762584811721 1.115141419669203 0.824468156622141 0.6986513008127613 0.08359694707443135 0.2797155725921667 1.4214328288360742 0.04107694402506584 0.09852133793141489 1.7301742943964836e-07 6.761910144685191 -0.2906732630470621 VHAVIGVLMDDTDPLVTVMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHAVIGVLMDDTDPLVTVMK 20 0 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 0 9117400.0 3250500.0 5866900.0 0.0 False True 4207836.326934103 5540401.857580412 0.0 1.0 1.3166866358647646 0.0 22.004647158243163 -6.878352340126557 1.343499879145457 1.1654913487872882 5.8016919974004535e-18 0.928717698813797 0.14981869451002672 0.15014035979264423 0.5447977097747838 0.0904222020676354 0.18461301061421156 1.3232675417352232e-07 6.878352340126557 -1.1654913487872882 down VHAYIISSLKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHAYIISSLKK 11 1 A0A024R571;Q9H4M9;C9JC03;C9J2Z4;Q9NZN3 A0A024R571 EHD1;EHD3 EH domain-containing protein 1;EH domain-containing protein 3 0 16350800.0 7754800.0 4186700.0 4409300.0 False True 10166617.89759003 3562060.6796287796 3953067.932992194 1.0 0.3503683049279502 0.38882821925758204 23.27733648560127 -9.902924733456663 5.743617248885217 1.00000031509171 0.36959826209191127 0.9972162355502258 0.015701194279484847 6.336583669861385e-08 1.2088818957751165e-08 0.015202623803921561 0.005067538662893238 1.2504757284126739e-10 9.902924733456663 -0.6304020529997988 VHAYIISSLKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHAYIISSLKK 11 1 A0A024R571;Q9H4M9;C9JC03;C9J2Z4;Q9NZN3 A0A024R571 EHD1;EHD3 EH domain-containing protein 1;EH domain-containing protein 3 0 6762620.0 2075700.0 611520.0 4075400.0 False True 2009808.039680734 855703.1250346709 3007930.4806206883 1.0 0.4257636093298755 1.4966257578999982 20.93862628295437 -6.7610412447799035 1.6085186007636552 0.6668848331107109 1.5007454089284447 0.6952215867310464 0.24156271871765014 0.2811690934457892 1.4340138529194582 0.1184769500362017 0.2844304589189802 1.733639346873884e-07 6.7610412447799035 0.8338605758177338 VHAYIISSLKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHAYIISSLKK 11 1 A0A024R571;Q9H4M9;C9JC03;C9J2Z4;Q9NZN3 A0A024R571 EHD1;EHD3 EH domain-containing protein 1;EH domain-containing protein 3 0 23134800.0 5063800.0 6680000.0 11391000.0 False True 7682154.813368099 5487901.808921778 9139563.857147338 1.0 0.7143701138867974 1.1897135737544795 22.8730796071619 -6.744015248033232 1.672302503289537 0.8308442100949404 1.1902266498778828 0.6227120099991326 0.12000399998418045 0.3105935387154698 1.7070192479105832 0.056738730271330994 0.1386063088751643 1.802954438209056e-07 6.744015248033232 0.3593824397829425 VHAYIISSLKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHAYIISSLKK 11 1 A0A024R571;Q9H4M9;C9JC03;C9J2Z4;Q9NZN3 A0A024R571 EHD1;EHD3 EH domain-containing protein 1;EH domain-containing protein 3 0 13770000.0 7754800.0 3177500.0 2837700.0 False True 10621959.12559017 3037107.543412645 2167493.7042660075 1.0 0.2859272482131585 0.20405780879387245 23.340546547124163 -13.999999999999998 0.30569032262903434 7.731243102206689 0.18507706038188282 0.9996624848698551 0.006567468528700422 16.968716045630952 0.1757688741405182 72.47785832405305 0.02888156980091225 1.0000000000000041e-14 13.999999999999998 -7.546166041824806 VHAYIISSLKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHAYIISSLKK 11 1 A0A024R571;Q9H4M9;C9JC03;C9J2Z4;Q9NZN3 A0A024R571 EHD1;EHD3 EH domain-containing protein 1;EH domain-containing protein 3 0 5508400.0 2075700.0 1665400.0 1767300.0 False True 1726036.519101428 1656428.1596439828 2136834.258928055 1.0 0.9596715604292757 1.2380006073338978 20.719031558388647 -6.87011241577075 1.133428430731858 0.9771735291026609 1.2543408746072937 0.9647989645861884 0.02304128750306355 0.13675090075339122 0.3282653520417349 0.01577501565876369 0.03735733197797123 1.3486137529485375e-07 6.87011241577075 0.27716734550463284 VHAYIISSLKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHAYIISSLKK 11 1 A0A024R571;Q9H4M9;C9JC03;C9J2Z4;Q9NZN3 A0A024R571 EHD1;EHD3 EH domain-containing protein 1;EH domain-containing protein 3 0 31644800.0 5063800.0 12015000.0 14566000.0 False True 6555188.922420825 11346354.687966177 11915137.459781153 1.0 1.7308966716669365 1.8176649980334822 22.644205929254348 -11.21981204122842 0.3750585307318319 2.8070542762762374e-14 1.8277148183710057 0.9995158936696605 0.008068599806972068 3.263886717201438 0.18781452816631408 2.752487414648799 0.023825665050422586 6.028204249199532e-12 11.21981204122842 1.8277148183709777 VHCCFYFISPFGHGLKPLDVAFMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VHCCFYFISPFGHGLKPLDVAFMK 24 1 Q15019;Q15019-2;Q15019-3;B5MCX3;C9J2Q4;C9JB25;H7C2Y0;H7C310 Q15019 SEPT2 Septin-2 0 386782300.0 99331300.0 118323000.0 169128000.0 False True 150692844.1907482 97207336.18818142 135699776.6685644 1.0 0.6450693575411954 0.9005057764839486 27.167035669759706 -9.97272498749402 6.097887373392767 1.0000001236587257 0.7727875670125477 0.5133732664351272 0.10428148135567676 1.7530959719291442e-07 2.960842145496589e-08 0.10097016431635487 0.03365670338401857 1.064817089228109e-10 9.97272498749402 -0.227212556646178 VHCCFYFISPFGHGLKPLDVAFMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VHCCFYFISPFGHGLKPLDVAFMK 24 1 Q15019;Q15019-2;Q15019-3;B5MCX3;C9J2Q4;C9JB25;H7C2Y0;H7C310 Q15019 SEPT2 Septin-2 0 296987300.0 99331300.0 108214300.0 89441700.0 False True 128586325.96264857 102192079.07698514 73164228.34934162 1.0 0.7947351968565431 0.5689891814048267 26.938161991852155 -6.969902842162016 0.2605049940658197 1.0629889012328275 0.29403359709561566 0.9999816110824776 0.0007548163643481971 0.07633430772158313 0.009143310169353906 0.004697175855986312 0.0212833864637434 1.0717590461261338e-07 6.969902842162016 -0.7689553041372119 VHFEESSK(ub)LEDLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHFEESSKLEDLLR 14 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 34922800.0 5748200.0 9405600.0 19769000.0 True False 5565726.537405597 13161305.129556034 14590905.842712441 1.0 2.3647056751895383 2.6215635541292395 22.408138595345335 -10.38415007920307 0.35775832036061006 8.697214174068722e-16 2.666024266420768 0.9990950658470236 0.021407600485369386 1.8389391442280012 0.1682217498772832 1.799416853039741 0.07420644755510335 4.129047897687847e-11 10.38415007920307 2.666024266420767 VHFEESSK(ub)LEDLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHFEESSKLEDLLR 14 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 32266200.0 5748200.0 14472000.0 12046000.0 True False 4779882.988437072 14394036.463532923 14564762.905588957 1.0 3.011378416240162 3.047096119470353 22.18854387077961 -10.586008650586546 0.7479236981627108 2.663642754346607e-10 3.040159489016056 0.9999623429070098 0.005870839517438724 2.081665750111689 0.3879457351137767 3.956156291373181 0.005344968061121825 2.594127689922816e-11 10.586008650586546 3.040159488749692 VHFEESSK(ub)LEDLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHFEESSKLEDLLR 14 1 P12956;B1AHC9;P12956-2 P12956 XRCC6 X-ray repair cross-complementing protein 6 1 141635000.0 10754000.0 14711000.0 116170000.0 True False 13921264.993031636 13892319.917991698 95028252.00485922 1.0 0.9979208013744134 6.8261219115092 23.7307869757038 -6.906811523448694 0.9171554936475237 0.8008503660267087 7.530172212573143 0.9896621407467806 0.2792969073868132 0.1065649670974615 0.15047639340372146 0.22511876250368096 0.6085362113731615 1.2393343202331012e-07 6.906811523448694 6.729321846546434 up VHFSQLEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHFSQLEKR 9 1 Q2NKJ3;Q2NKJ3-2;J3KSR1 Q2NKJ3 CTC1 CST complex subunit CTC1 1 15710200.0 2094900.0 3369300.0 10246000.0 True False 3178116.45770466 2768022.090538949 8220873.609018661 1.0 0.870963077463217 2.5867125130323405 21.59974056055392 -6.888774768458963 1.0296282859587682 0.9050843421759441 2.7307751102027975 0.9801015079624671 0.1100535191257258 0.12014187217612732 0.22771195671932576 0.08157159971958947 0.2024780427301832 1.2918890926985254e-07 6.888774768458963 1.8256907680268535 up VHFSQLEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHFSQLEKR 9 1 Q2NKJ3;Q2NKJ3-2;J3KSR1 Q2NKJ3 CTC1 CST complex subunit CTC1 1 13714100.0 2094900.0 4701900.0 6917300.0 True False 2711889.3466525944 4440235.131697723 5658422.377491713 1.0 1.6373216470570608 2.0865240628184756 21.370866882646368 -7.638476850479601 0.11497964886309475 1.0378408793110138e-19 3.4361352654661372 0.9999924349149606 0.0012260970635913063 0.13972148462547673 0.012677027555830453 0.14974292059114677 0.2099440121286806 2.2989162468333662e-08 7.638476850479601 3.4361352654661372 VHFTAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHFTAER 7 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 13890500.0 2773600.0 4252700.0 6864200.0 False True 3636216.459580604 3618213.7368947687 6153958.430055799 1.0 0.995049050878585 1.6924070660979262 21.79400665330843 -6.905301607591868 0.9271530271746139 0.9750705857374056 1.7740233856767371 0.9890239275804413 0.03431917870066466 0.10760745881734315 0.15623381275276305 0.027460454289568195 0.07354747127752305 1.243650624861236e-07 6.905301607591868 0.7989527999393315 VHFTAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHFTAER 7 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 5888820.0 2038500.0 993020.0 2857300.0 False True 1973788.9333184867 1389538.0645308895 2108887.4128373857 1.0 0.7039952656917022 1.0684462645617132 20.91253629309254 -6.6907092344622905 1.8642458734638767 0.8145455793752999 1.067186211317292 0.37364342039799925 0.1251712358339233 0.4151154876223124 2.7977775681455834 0.053707029716180785 0.13971387764697532 2.0384063592719123e-07 6.6907092344622905 0.25264063194199216 VHFTAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHFTAER 7 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 12564700.0 2773600.0 3627100.0 6164000.0 False True 3799074.8737216764 3466842.728784264 4708190.151564882 1.0 0.9125491979019753 1.2392991209864237 21.85721671483132 -6.835490407577873 1.3032317856466467 0.9534189751722478 1.2491177054447828 0.9164074509883223 0.0399317981256346 0.1741340124696649 0.5764455781949585 0.02404297331558358 0.055339504319030494 1.4605270082831663e-07 6.835490407577873 0.295698730272535 VHFTAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHFTAER 7 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 3871650.0 2038500.0 1105100.0 728050.0 False True 1695103.0708620064 1099146.6069548256 880281.8888771388 1.0 0.6484246449957048 0.5193087688936174 20.692941568526816 -13.999999999999979 0.139242467236051 2.6783246840864727 0.3580533732357495 0.9996059706971763 0.00403207445900456 11.933275830760868 0.11685574863093008 5.444124170712188 0.14408773641767203 1.000000000000049e-14 13.999999999999979 -2.3202713108507234 VHGLALQISENLFSNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHGLALQISENLFSNK 16 0 A0A087WVM4;B7ZM99;Q6UB35;H0Y327;Q6UB35-2;Q5JYA8;Q5JYA3 A0A087WVM4 MTHFD1L Monofunctional C1-tetrahydrofolate synthase, mitochondrial 0 18668100.0 4749000.0 6438400.0 7480700.0 False True 7204580.198405379 5289417.21655119 6002136.366092719 1.0 0.7341742434516753 0.8331000836691633 22.780482938194222 -10.35673348293358 5.066164776487515 1.0001192033595905 0.78363716356039 0.8644619273254279 0.04038630515159234 5.440541036407691e-05 6.908013557737101e-06 0.039125339487918326 0.013034623938899429 4.3981143533866536e-11 10.35673348293358 -0.21648203979920044 VHGLALQISENLFSNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHGLALQISENLFSNK 16 0 A0A087WVM4;B7ZM99;Q6UB35;H0Y327;Q6UB35-2;Q5JYA8;Q5JYA3 A0A087WVM4 MTHFD1L Monofunctional C1-tetrahydrofolate synthase, mitochondrial 0 15378000.0 4749000.0 5887000.0 4742000.0 False True 6147674.116785131 5559383.274911099 3879004.6570288506 1.0 0.9043067620861996 0.6309710930249081 22.55160926028667 -6.952548065463447 0.5301321408070019 1.00430682977262 0.5185598440253384 0.9993863755057024 0.0038733985515656544 0.08247840411837738 0.031850535064808325 0.004320511263768826 0.022603788491926374 1.1154546917722372e-07 6.952548065463447 -0.4857469857472817 VHIDIGADGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHIDIGADGR 10 0 P31942-2;P31942;P31942-3;P31942-4;P31942-6;P31942-5 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 49774000.0 18560000.0 12723000.0 18491000.0 False True 24332339.7352957 10824777.993865566 16577728.698196717 1.0 0.44487205552877823 0.6813043414049329 24.536371717007896 -10.314544429388729 5.760899688154862 1.0000491533353568 0.5630881984668566 0.8199222867389145 0.09652307651941174 6.094312057299122e-05 7.2513786191522205e-06 0.09346854039603986 0.03115268899036428 4.846805260835948e-11 10.314544429388729 -0.4369609548685002 VHIDIGADGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHIDIGADGR 10 0 P31942-2;P31942;P31942-3;P31942-4;P31942-6;P31942-5 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 15983900.0 10520000.0 5463900.0 0.0 False True 10186048.358356869 7645663.7638620855 0.0 1.0 0.7506015576285191 0.0 23.280091135783657 -7.33315897465539 0.7980043477228908 0.9892341342249656 5.984943106656073e-23 0.9879677170921028 0.04661867323627687 0.1072779905763832 0.1376777295971538 0.039934780445568245 0.0709516791917005 4.6434526928268734e-08 7.33315897465539 -0.9892341342249656 down VHIDIGADGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHIDIGADGR 10 0 P31942-2;P31942;P31942-3;P31942-4;P31942-6;P31942-5 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 46682000.0 18560000.0 11694000.0 16428000.0 False True 25422133.56514078 11177320.413113287 12548044.745280316 1.0 0.4396688572370574 0.49358739749862646 24.599581778530787 -10.70616804012821 10.522900669735924 1.0004315842441847 0.46662812805335857 0.9923939107479597 0.022012151886092544 0.00022303318136760437 6.227746565725841e-06 0.02132808704306461 0.007104391472418721 1.9671250092594872e-11 10.70616804012821 -0.533803456190826 VHIEIGPDGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHIEIGPDGR 10 0 P55795;P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7;P52597 P55795;P31943;P52597 HNRNPH2;HNRNPH1;HNRNPF Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 219789000.0 96051000.0 63442000.0 60296000.0 False True 125923791.15920722 53976700.89497908 54057148.32007296 1.0 0.4286457737500579 0.4292846317796114 26.90797564060532 -10.043924436514258 5.6415012615486395 1.0000023065404016 0.4289652027646402 0.9999990608019328 0.0002608126991010613 7.566210354731665e-09 1.2820255661483386e-09 0.0002525318292671733 8.417693657492023e-05 9.038067145983219e-11 10.043924436514258 -0.5710371037757613 VHIEIGPDGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHIEIGPDGR 10 0 P55795;P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7;P52597 P55795;P31943;P52597 HNRNPH2;HNRNPH1;HNRNPF Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 180773000.0 64772000.0 28374000.0 87627000.0 False True 62715848.3144003 39703886.168455265 64674859.94634846 1.0 0.633075805168353 1.0312363092360237 25.902326722796147 -6.664431226336615 1.9568609824297507 0.7646897739099546 1.029604261495159 0.25477984825284683 0.15606255701869462 0.4739978077253812 3.49362241930856 0.0643251207421822 0.1731342437655518 2.165552783057954e-07 6.664431226336615 0.2649144875852044 VHIEIGPDGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHIEIGPDGR 10 0 P55795;P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7;P52597 P55795;P31943;P52597 HNRNPH2;HNRNPH1;HNRNPF Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 204438000.0 45972000.0 146174000.0 12292000.0 False True 69742885.00338854 120088107.6373251 9862480.812225007 1.0 1.721868942351474 0.14141199939959218 26.05554270848092 -6.782509103837469 1.5259877997558509 1.4074063522900853 0.12786872659052836 0.7762053627713984 0.3056137328475038 0.24669377222352695 1.1347910885693127 0.15771052116675896 0.37137455519321205 1.6500264125092928e-07 6.782509103837469 -1.279537625699557 VHIEIGPDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHIEIGPDGR 10 0 P55795;P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7;P52597 P55795;P31943;P52597 HNRNPH2;HNRNPH1;HNRNPF Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 232173000.0 96051000.0 61202000.0 74920000.0 False True 131563650.38067542 58497893.27205047 57225439.02583408 1.0 0.44463568092545774 0.43496390424143766 26.97118570212821 VHIEIGPDGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHIEIGPDGR 10 0 P55795;P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7;P52597 P55795;P31943;P52597 HNRNPH2;HNRNPH1;HNRNPF Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 132915800.0 64772000.0 47857000.0 20286800.0 False True 53860787.886128955 47599184.84212919 24528676.08443483 1.0 0.8837446816181398 0.4554087871178696 25.682731998230423 -6.946764685048259 0.5933041833436111 1.0049045929918023 0.3125730532889965 0.998922283099774 0.007687830842405286 0.08481156330127299 0.04154427639497219 0.007943363906557479 0.035919899095479234 1.130408240917947e-07 6.946764685048259 -0.6923315397028058 down VHIEIGPDGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHIEIGPDGR 10 0 P55795;P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7;P52597 P55795;P31943;P52597 HNRNPH2;HNRNPH1;HNRNPF Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed;Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 119850000.0 45972000.0 62042000.0 11836000.0 False True 59511660.24359783 58589308.160698816 9681969.447615672 1.0 0.9845013216044795 0.1626902930952467 25.82666903057337 -6.910985534908602 0.889006248363856 1.02465898616162 0.0542189616899528 0.991287890301319 0.03650566301592418 0.1037699377457399 0.13526281455581185 0.030034014429142906 0.08348360480399808 1.22748011428516e-07 6.910985534908602 -0.9704400244716672 down VHIGQVIMSIR ddPTM_RPMI8226_Bortezomib_1h_R1 2 VHIGQVIMSIR 11 0 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 0 274577900.0 81173000.0 91207900.0 102197000.0 False True 106418589.08045022 77600036.84560966 91622634.7828462 1.0 0.7291962571214476 0.8609645699547981 26.665174940311516 -10.128668734463652 4.744910962923203 1.0000145982474238 0.7950804135375845 0.7632944661441011 0.05379418845876269 75103385.07568358 0.46328279882395795 12339.445420445649 0.018415181549872855 7.435861046435193e-11 10.128668734463652 -0.20493418470983926 VHIGQVIMSIR ddPTM_RPMI8226_Bortezomib_2h_R1 2 VHIGQVIMSIR 11 0 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 0 244869800.0 97117700.0 68415300.0 79336800.0 False True 94034751.77304126 95733886.07107617 58556112.02701746 1.0 1.0180692166034093 0.6227071473357667 26.486690686376715 -6.89619269588009 0.9850444216469944 1.0181985043697308 0.5842747796282741 0.9845743894813369 0.022637396151933723 0.11426156966064932 0.19365521504598848 0.0173521816101997 0.044342951380990744 1.270010478228905e-07 6.89619269588009 -0.4339237247414567 VHIGQVIMSIR ddPTM_RPMI8226_Bortezomib_8h_R1 2 VHIGQVIMSIR 11 0 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 0 654155000.0 146516000.0 203591000.0 304048000.0 False True 222275483.75438264 167258595.38625675 243952779.53102773 1.0 0.7524833263711608 1.097524456635977 27.72777359178018 -6.714124396160015 1.7801511683148035 0.848483223811652 1.0968299774810553 0.48486086039468035 0.10423706880524854 0.36682755337755824 2.268373203278228 0.04655053274974326 0.11768811032395075 1.9314150172765494e-07 6.714124396160015 0.2483467536694033 VHIGQVIMSIR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VHIGQVIMSIR 11 0 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 0 314294400.0 81173000.0 93539000.0 139582400.0 False True 111184851.71784325 89406137.68789148 106615911.90976475 1.0 0.8041215714779187 0.9589068138556032 26.728385001834408 -9.92804224440345 5.192298356191016 1.0000003219154365 0.8815141927014293 0.43860911387241286 0.06319081059444089 2.3545961807885849e-07 4.863872284268158e-08 0.06118440519619452 0.020394746421456042 1.1802058298731157e-10 9.92804224440345 -0.11848612921400725 VHIGQVIMSIR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VHIGQVIMSIR 11 0 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 0 183828100.0 97117700.0 42249000.0 44461400.0 False True 80757670.59360065 42021396.25123013 53758073.1737135 1.0 0.5203393800533911 0.6656714189323505 26.26709596181099 -10.786421129030256 10.568132089258416 1.0022514324831906 0.5930053994928766 0.9127145823485364 0.059331556421962854 0.0031552915325086524 6.376743623780654e-05 0.05759248265344402 0.019149177493902308 1.635230093592112e-11 10.786421129030256 -0.40924603299031403 VHIGQVIMSIR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VHIGQVIMSIR 11 0 F8W7C6;H7C123;H7C2C5;P27635;X1WI28;A0A087WV22;Q96L21 F8W7C6;P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 0 644738000.0 146516000.0 293666000.0 204556000.0 False True 189667850.26213744 277323228.94683903 167328906.92180377 1.0 1.4621520123919485 0.8822207173779884 27.49889991387263 -6.694401150262839 1.8505558052442739 1.2885322105796446 0.8840993579902413 0.391194832553705 0.19528617118497563 0.40728011067136277 2.707413976315048 0.08431162330086689 0.2183610324169756 2.0211514137763642e-07 6.694401150262839 -0.4044328525894033 VHILGSFQNIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHILGSFQNIK 11 0 Q9NRX1 Q9NRX1 PNO1 RNA-binding protein PNO1 0 11106000.0 2930700.0 2050400.0 6124900.0 False True 3842176.0809391737 1744488.3123966025 5491154.102189448 1.0 0.4540365344136397 1.4291781497029155 21.87349220630698 -6.754800270601853 1.6322773368008412 0.6808226581258708 1.4318227774523529 0.6692625819858964 0.2294929988682515 0.2917574383603019 1.5308000732910754 0.11100481771306171 0.26812477932877266 1.7587322582976642e-07 6.754800270601853 0.751000119326482 VHILGSFQNIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHILGSFQNIK 11 0 Q9NRX1 Q9NRX1 PNO1 RNA-binding protein PNO1 0 5094900.0 2930700.0 2164200.0 0.0 False True 4014258.9891895493 2068578.4879476433 0.0 1.0 0.5153076803261453 0.0 21.936702267829872 -7.882133439073236 0.6025014423748412 1.0082614618168877 4.260337048299954e-18 0.9886417401446708 0.04351591348337216 0.11378450257035572 0.1594881706618904 0.044208381666523015 0.07740576925679644 1.3117967812074193e-08 7.882133439073236 -1.0082614618168877 down VHILYVGSMPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHILYVGSMPLK 12 0 Q9Y3B2;R4GNH9;R4GMQ7;B1AMU3;B1AMU4 Q9Y3B2 EXOSC1 Exosome complex component CSL4 0 36450400.0 8776300.0 19260200.0 8413900.0 False True 11505814.289810099 16386653.235671591 7543310.339827878 1.0 1.4242063032587022 0.655608560144106 23.455859753840414 -6.756890212307628 1.6242607774104394 1.2473587872909448 0.6532343815863071 0.6780793872973234 0.1783516065948968 0.2881902771402349 1.4977681469160569 0.0866686877821493 0.20891608163594294 1.750289097917153e-07 6.756890212307628 -0.5941244057046378 VHILYVGSMPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHILYVGSMPLK 12 0 Q9Y3B2;R4GNH9;R4GMQ7;B1AMU3;B1AMU4 Q9Y3B2 EXOSC1 Exosome complex component CSL4 0 52060000.0 8776300.0 17886100.0 25397600.0 False True 12021135.280589698 17095832.96057685 19399209.95999097 1.0 1.4221479553749945 1.6137585600017756 23.519069815363306 -11.367783968671727 0.14157506712967802 1.4233188770411948e-16 1.8883007275567438 0.9996738688333913 0.004630171926672197 3.9893583260005974 0.08882881627755054 1.4490138493060472 0.198921745818608 4.287617465373129e-12 11.367783968671727 1.8883007275567436 VHILYVGSMPLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHILYVGSMPLK 12 0 Q9Y3B2;R4GNH9;R4GMQ7;B1AMU3;B1AMU4 Q9Y3B2 EXOSC1 Exosome complex component CSL4 0 24456500.0 15985700.0 0.0 8470800.0 False True 13292817.836585118 0.0 10242005.115446016 1.0 0.0 0.7704916475465036 23.6641436264595 -10.842539761848181 9.941818424891542 1.0167209285293473 0.38524582432563415 0.45910888015234574 0.31455189792754534 0.10444753622289218 0.001654254958136054 0.2728698377668517 0.1015211885159432 1.4370114816913631e-11 10.842539761848181 -0.6314751042037131 VHIPNDDAQFDASHCDSDK(ub)GEFGGFGSVTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHIPNDDAQFDASHCDSDKGEFGGFGSVTGK 31 1 Q16576;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 65483500.0 24015300.0 29498000.0 11970200.0 True False 31484290.864496056 25097013.38230343 10731638.530266305 1.0 0.7971281135191336 0.34085692374186743 24.908128837429164 -6.957686939962771 0.4669001151586066 1.012421623354801 0.10695613114108929 0.9996745288479952 0.004972816407713927 0.08053810123077078 0.024265300700548522 0.006272562854612373 0.03766754199859006 1.102333637521309e-07 6.957686939962771 -0.9054654922137116 down VHIPNDDAQFDASHCDSDK(ub)GEFGGFGSVTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHIPNDDAQFDASHCDSDKGEFGGFGSVTGK 31 1 Q16576;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 70703800.0 43336000.0 18144100.0 9223700.0 True False 41960322.40092707 25389133.75023155 6807736.264931304 1.0 0.6050748015623113 0.1622422296922317 25.322522427075043 -7.601180135887935 0.41629805466782593 1.0362620071719175 6.872707667579257e-24 0.9983358529824464 0.013959672201686866 0.12027730850325513 0.059802645017068945 0.023628285939553885 0.0718419028939066 2.5050699890683176e-08 7.601180135887935 -1.0362620071719175 down VHIPNDDAQFDASHCDSDK(ub)GEFGGFGSVTGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHIPNDDAQFDASHCDSDKGEFGGFGSVTGK 31 1 Q16576;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 300716000.0 85333000.0 66934000.0 148449000.0 True False 129456399.67793779 54989104.74227105 119107990.08249186 1.0 0.42476930363483917 0.9200625877037307 26.947891045738306 -10.265063607838632 8.101228519372302 1.0000003642798034 0.6724159456692888 0.3683902838470414 0.20220263649935746 1.3303641414920038e-06 1.206389259568687e-07 0.19578207972465622 0.06526062031010361 5.431707715383417e-11 10.265063607838632 -0.3275844186105147 VHIPNDDAQFDASHCDSDK(ub)GEFGGFGSVTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHIPNDDAQFDASHCDSDKGEFGGFGSVTGK 31 1 Q16576;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 104088400.0 24015300.0 55988000.0 24085100.0 True False 32894405.39908003 53514265.032442875 18396695.428204983 1.0 1.6268500489125586 0.5592651760995044 24.971338898952055 -6.747547927235569 1.658703403910761 1.3696673120037224 0.5575036076666019 0.6384747175295378 0.26338127745227496 0.3043245452454495 1.64654501340901 0.12547163883509543 0.3054254191088334 1.7883481623053785e-07 6.747547927235569 -0.8121637043371205 VHIPNDDAQFDASHCDSDK(ub)GEFGGFGSVTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHIPNDDAQFDASHCDSDKGEFGGFGSVTGK 31 1 Q16576;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 74321500.0 43336000.0 14476500.0 16509000.0 True False 36035804.110314354 14398512.221139718 19960955.571008425 1.0 0.3995612856885994 0.5539200820912193 25.10292770250932 -10.417846136480035 9.07980975160922 1.0000027093845056 0.4767406838902613 0.9387322629416166 0.06301671474942909 3.45625026377704e-06 2.2170059831766216e-07 0.061015986987505225 0.020338557229770182 3.820796114989113e-11 10.417846136480035 -0.5232620254942444 VHIPNDDAQFDASHCDSDK(ub)GEFGGFGSVTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHIPNDDAQFDASHCDSDKGEFGGFGSVTGK 31 1 Q16576;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 372755000.0 85333000.0 75618000.0 211804000.0 True False 110465250.66490331 71409791.82643567 173257845.2925641 1.0 0.6464457501034194 1.5684375335203133 26.719017367830755 -6.802756788046737 1.4445755157868898 0.8056031524426349 1.5820554616337281 0.8401078956404757 0.1518663302469635 0.21685105697654128 0.893076356809921 0.0826922425655417 0.19200270020638313 1.5748645672580975e-07 6.802756788046737 0.7764523091910932 VHK(ub)TDLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHKTDLER 8 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 253253200.0 60003000.0 110668000.0 82582200.0 True False 78664514.06987853 94156765.78048536 74037386.12839875 1.0 1.1969407920939408 0.9411789674646759 26.2292096402123 -6.701062623734013 1.8273139846890631 1.1221674740646865 0.9419306986265183 0.4224992700528627 0.08311541870481678 0.39332498275228067 2.554114256377172 0.03627878082492985 0.09316916791966365 1.9903863116006948e-07 6.701062623734013 -0.18023677543816818 VHK(ub)TDLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHKTDLER 8 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 270903700.0 74938900.0 114561000.0 81403800.0 True False 72560005.63898003 160305804.72772262 60081702.71834666 1.0 2.209286001510515 0.828027812143252 26.112671232196607 -6.675362506059603 1.9180226591270888 1.7682663268933174 0.8334121581683254 0.3032113819840282 0.513047187776402 0.4488897647149141 3.1884984399339023 0.21493992929853997 0.5703512009662548 2.1117256443745307e-07 6.675362506059603 -0.934854168724992 VHK(ub)TDLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHKTDLER 8 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 202533000.0 60003000.0 79606100.0 62923900.0 True False 82187730.6201045 76088839.27983047 48062570.77839936 1.0 0.9257931653026791 0.5847900947716695 26.29241970173519 -6.941704938825476 0.6435142536544104 1.003743530305231 0.4880313346729016 0.998378700324619 0.00727986762017097 0.08699758599939239 0.05113326292742154 0.007181489357186432 0.029136128178014236 1.1436550741168671e-07 6.941704938825476 -0.5157121956323293 VHK(ub)TDLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHKTDLER 8 1 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 179713066.0 74938900.0 101094000.0 3680166.0 True False 62315015.706166714 100549386.55641218 4449671.695434973 1.0 1.6135659345819884 0.07140609121269356 25.893076507630884 -6.798753982737829 1.4610362617575454 1.3390735339791418 0.05077972687738827 0.8284700383988005 0.26255687952396595 0.22254993645570406 0.9380187874784276 0.14138335504002925 0.3290522114196207 1.5894468766244337e-07 6.798753982737829 -1.2882938071017536 VHLDK(ub)AQQNNVEHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHLDKAQQNNVEHK 14 1 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 15717120.0 4215340.0 7204800.0 4296980.0 True False 5526351.561410634 6129871.924090442 3852369.7291426817 1.0 1.1092077396765827 0.6970909625154831 22.397895912106247 -6.8362252371415115 1.299684227674797 1.0581557210981154 0.6845080065996744 0.9177855176298627 0.0499859338210217 0.17325620060110067 0.5700991258163797 0.030174036821539782 0.06946534343682507 1.4580578749716572e-07 6.8362252371415115 -0.37364771449844103 VHLDK(ub)AQQNNVEHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHLDKAQQNNVEHK 14 1 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 17318200.0 8452800.0 1260500.0 7604900.0 True False 8184470.4908287935 1763824.223420662 5612948.547890331 1.0 0.21550865451798457 0.6858047266686327 22.964457651268994 -8.956626332444575 11.80142453035198 0.999995610148568 0.4506565085437365 0.6452911643695471 0.1919975674853089 0.0 0.0 0.1859008453377336 0.06196694844591119 1.1050289794159293e-09 8.956626332444575 -0.5493391016048315 VHLDK(ub)AQQNNVEHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHLDKAQQNNVEHK 14 1 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 24979100.0 3796700.0 2809400.0 18373000.0 True False 5759871.475949817 2308040.6200576145 14741568.496828046 1.0 0.4007104376711831 2.559357193711883 22.457605189485072 -6.8326370847243325 1.3160580667090127 0.6803177755126367 2.6206489941390583 0.9110527066328552 0.2713549723715046 0.17757825851471354 0.600578437909886 0.16184330838929822 0.3724517583422511 1.470154289069817e-07 6.8326370847243325 1.9403312186264214 up VHLDK(ub)AQQNNVEHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHLDKAQQNNVEHK 14 1 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 14544440.0 4215340.0 6269900.0 4059200.0 True False 5773865.1132802 5992875.086213349 3100500.561848184 1.0 1.0379312589809926 0.5369887416865465 22.461105973629138 -6.888643039740283 1.0304030298811253 1.0277984619784362 0.49503548983279305 0.9800144809316371 0.032194673110684295 0.12024994961041202 0.2283473389537193 0.023848684255882165 0.059170549663317445 1.2922810035184871e-07 6.888643039740283 -0.532762972145643 VHLDK(ub)AQQNNVEHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHLDKAQQNNVEHK 14 1 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 21548400.0 8452800.0 12619200.0 476400.0 True False 7028877.722532431 12551217.864884907 576013.0373752756 1.0 1.7856645627294874 0.081949503194337 22.74486292670327 -6.78129774067055 1.53071524268883 1.444101801002249 0.06786847494060337 0.7720164733730466 0.3324372439240524 0.24854620971063632 1.1503469966477124 0.17103692209181404 0.40315649628431927 1.6546352009340736e-07 6.78129774067055 -1.3762333260616457 VHLDK(ub)AQQNNVEHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHLDKAQQNNVEHK 14 1 P62081;B5MCP9;A0A2R8Y623 P62081 RPS7 40S ribosomal protein S7 1 32246760.0 3796700.0 3769460.0 24680600.0 True False 4914902.994145733 3559686.237378352 20188984.0443413 1.0 0.724263783358163 4.107707531234882 22.22873151157752 -6.88715041617353 1.0391204854347857 0.8055904438918565 4.382943711837628 0.979009768735491 0.22226261090175053 0.1214844637298909 0.23561148376092667 0.16355876231238314 0.40377770327668405 1.29673007587465e-07 6.88715041617353 3.5773532679457714 up VHLDLWVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHLDLWVK 8 0 P17480;E9PKP7;P17480-2;H0YDH7 P17480 UBTF Nucleolar transcription factor 1 0 8237500.0 2165200.0 3524600.0 2547700.0 False True 2838598.167826627 2998743.4187831907 2284088.443264063 1.0 1.0564170204757015 0.8046536734760439 21.43674720482024 -6.847873126415778 1.245334623311602 1.030059694674883 0.7949959081247807 0.9371500296684492 0.02704346708544481 0.15981193050650092 0.4780147831774218 0.017001695868999866 0.03929265638004284 1.4194721417738143e-07 6.847873126415778 -0.2350637865501023 VHLDLWVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHLDLWVK 8 0 P17480;E9PKP7;P17480-2;H0YDH7 P17480 UBTF Nucleolar transcription factor 1 0 14136600.0 6257500.0 3335100.0 4544000.0 False True 6058859.0876823235 4666822.822316744 3353790.082922021 1.0 0.7702477900178282 0.5535349204176551 22.530614722179685 -6.971832072792302 0.20986786965483223 1.1136532209346175 0.20408061413890347 0.9999933637410077 0.0004695722695022359 0.07571262610232082 0.006860829092316276 0.0064963640416575655 0.022463579904751122 1.0670086181611226e-07 6.971832072792302 -0.9095726067957141 VHLDLWVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHLDLWVK 8 0 P17480;E9PKP7;P17480-2;H0YDH7 P17480 UBTF Nucleolar transcription factor 1 0 61156000.0 16511000.0 21482000.0 23163000.0 False True 25048394.115786754 17648369.260367926 18584822.89729646 1.0 0.7045708870112771 0.7419566624266491 24.57821477759387 -10.364875683491366 8.746448122910499 1.0000007708753011 0.7232637748188746 0.9864967673014243 0.015262678900991547 2.294343201402865e-07 1.666729805284556e-08 0.014778066476242111 0.004926008433504297 4.316426165592688e-11 10.364875683491366 -0.27673699605642654 VHLDLWVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHLDLWVK 8 0 P17480;E9PKP7;P17480-2;H0YDH7 P17480 UBTF Nucleolar transcription factor 1 0 14641400.0 2165200.0 4120500.0 8355700.0 False True 2965732.9523298903 3938442.685328652 6382255.751043266 1.0 1.3279829130382752 2.1519994731924004 21.49995726634313 -6.955355940147355 0.4965804318609115 0.9829969464707833 2.5323197722022215 0.9995573039441277 0.01019649721320774 0.08140376152938844 0.027593885740026088 0.012036184196242252 0.06796736058746242 1.1082661274427252e-07 6.955355940147355 1.5493228257314382 up VHLDLWVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHLDLWVK 8 0 P17480;E9PKP7;P17480-2;H0YDH7 P17480 UBTF Nucleolar transcription factor 1 0 9074900.0 6257500.0 0.0 2817400.0 False True 5203388.504252633 0.0 3406505.3138142377 1.0 0.0 0.6546705691935484 22.31101999761396 -10.321453124029542 7.599549057829683 1.000004689735782 0.32733528459677425 0.5846548403981333 0.2672681406902703 2.1236723113664167e-05 1.895736808087196e-06 0.2587830673886146 0.08626042148876976 4.770313001484354e-11 10.321453124029542 -0.6726694051390076 VHLDLWVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHLDLWVK 8 0 P17480;E9PKP7;P17480-2;H0YDH7 P17480 UBTF Nucleolar transcription factor 1 0 58211000.0 16511000.0 20976000.0 20724000.0 False True 21373814.98046733 19808667.160614073 16952444.646196954 1.0 0.9267726504939066 0.7931407968904527 24.34934109968632 -6.961796573063899 0.4093295894409094 1.006631123684306 0.708328537601219 0.999831127678652 0.0011129059786576215 0.07906551533721251 0.01880540645700301 0.0017204506945403466 0.011159689278075162 1.0919516954018786e-07 6.961796573063899 -0.2983025860830869 VHLFGASLGGFLAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHLFGASLGGFLAQK 15 0 Q9NZD8;H0YMB7;H0YKB0 Q9NZD8 SPG21 Maspardin 0 7464600.0 2399800.0 3211100.0 1853700.0 False True 3146161.039696256 2732016.396769767 1661896.9059459877 1.0 0.8683650843993439 0.5282300826236264 21.585161087892462 -6.954750608132038 0.5040055736526118 1.0065816531511802 0.37524303334158865 0.9995232542926498 0.004340046108750378 0.08163247593624169 0.02848850972689502 0.005052217152719698 0.028062569764670295 1.1098119373754788e-07 6.954750608132038 -0.6313386198095916 VHLFGASLGGFLAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHLFGASLGGFLAQK 15 0 Q9NZD8;H0YMB7;H0YKB0 Q9NZD8 SPG21 Maspardin 0 8068100.0 2825000.0 1845800.0 3397300.0 False True 2735321.9213268203 2582837.565719838 2507445.213184634 1.0 0.9442535979337243 0.9166910825502944 21.383279203793904 -13.999999929757255 0.09196740952597654 1.283101561267077 0.849925720173773 0.9998330788499221 0.0004476777931862204 12.146300057045782 0.088589370743568 0.6678782327803724 0.059884365992152855 1.0000001617399105e-14 13.999999929757255 -0.4331758410933041 VHLFGASLGGFLAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHLFGASLGGFLAQK 15 0 Q9NZD8;H0YMB7;H0YKB0 Q9NZD8 SPG21 Maspardin 0 11578400.0 2399800.0 3458400.0 5720200.0 False True 3287070.9121565046 3305596.4526005606 4369206.571216982 1.0 1.0056358809831403 1.3292097091846842 21.648371149415354 -6.910681315289479 0.8911020334558366 0.9901954658695521 1.3716383649686217 0.9911753022487847 0.014455442111134227 0.10396989537902256 0.1363450749450633 0.011874755186109986 0.03293567370381149 1.228340254970744e-07 6.910681315289479 0.3814428990990696 VHLFGASLGGFLAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHLFGASLGGFLAQK 15 0 Q9NZD8;H0YMB7;H0YKB0 Q9NZD8 SPG21 Maspardin 0 7843300.0 2825000.0 2287000.0 2731300.0 False True 2349112.6687197285 2274679.4770660438 3302402.201895658 1.0 0.9683143373049659 1.4058083487734432 21.16368447922818 -6.889488889295853 1.0254263168964666 0.9762039929621462 1.4430587924689295 0.9805682296492557 0.027766489264411557 0.11955782911113551 0.2242901086634503 0.02064612733281141 0.051376141860793666 1.2897665540151913e-07 6.889488889295853 0.4668547995067833 VHLMNPMVPGLTGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHLMNPMVPGLTGSK 15 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 8275800.0 1923700.0 2592000.0 3760100.0 False True 2521989.3291372997 2205283.703536868 3371040.9214260713 1.0 0.8744222975325723 1.3366594705534334 21.266130740774102 -6.834343756658952 1.3084667622977288 0.9330754542396507 1.350231526601704 0.914271340574206 0.05714059853138971 0.1755124708405962 0.5861418386124827 0.0342720086965466 0.07887340786819141 1.4643882763747113e-07 6.834343756658952 0.4171560723620533 VHLMNPMVPGLTGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHLMNPMVPGLTGSK 15 0 P54577;A0A0C4DGZ5 P54577 YARS Tyrosine--tRNA ligase, cytoplasmic;Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed;Tyrosine--tRNA ligase 0 6854000.0 1923700.0 1860200.0 3070100.0 False True 2634943.876037783 1778010.2131412132 2345005.6106942487 1.0 0.674781056746773 0.8899641590167301 21.329340802296993 -10.363007149769121 4.977114031058245 1.0001470034425568 0.782372607881707 0.5769517103704809 0.08784813363857473 0.0001433940836187174 1.8352212203151043e-05 0.08511580131907344 0.028352863214778257 4.335037415775812e-11 10.363007149769121 -0.21777439556084977 VHLQFLGHPILNDPIYNSVAWGPSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHLQFLGHPILNDPIYNSVAWGPSR 25 0 Q8IZ73-2;Q8IZ73 Q8IZ73-2 RPUSD2 RNA pseudouridylate synthase domain-containing protein 2 0 71348000.0 38099000.0 13048000.0 20201000.0 False True 57798968.40999081 10719482.455510681 16208263.495587183 1.0 0.18546148400907742 0.2804247885639688 25.78454040809542 -10.610571031432567 6.539910959822657 1.0021776936289741 0.23294313672338823 0.9886354053633142 0.03876860674133358 0.0012331435079607992 7.342934818867352e-05 0.037603546587169336 0.012512514022070785 2.45148346639025e-11 10.610571031432567 -0.7692345569055858 VHLQFLGHPILNDPIYNSVAWGPSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHLQFLGHPILNDPIYNSVAWGPSR 25 0 Q8IZ73-2;Q8IZ73 Q8IZ73-2 RPUSD2 RNA pseudouridylate synthase domain-containing protein 2 0 22259900.0 12803000.0 3754900.0 5702000.0 False True 10646261.769068547 3734671.6084107095 6894261.836930772 1.0 0.3507965227063415 0.6475758333278291 23.343843608844587 -10.482250168029408 6.233700133106448 1.0002966054385733 0.4991861780172007 0.7915301108619306 0.12115964620626615 0.0004997284260382647 4.1505661375548454e-05 0.11737966220844274 0.03910410766577094 3.2941990072245234e-11 10.482250168029408 -0.5011104274213727 VHLQFLGHPILNDPIYNSVAWGPSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHLQFLGHPILNDPIYNSVAWGPSR 25 0 Q8IZ73-2;Q8IZ73 Q8IZ73-2 RPUSD2 RNA pseudouridylate synthase domain-containing protein 2 0 53618300.0 38099000.0 8343900.0 7175400.0 False True 49319906.54356633 7879554.630122413 5869550.825821344 1.0 0.15976418412638463 0.11900977185827642 25.55566673018787 -13.301396093570157 0.4384577608166919 9.99999999999954 0.11853968052353317 0.9998750558578082 0.004538623561283499 17.59029950285819 0.22287340479319814 149.32233332775198 0.009452741206909086 4.995786918096964e-14 13.301396093570157 -9.881460319476007 VHLVGIDIFTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHLVGIDIFTGK 12 0 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 947130890.0 375435720.0 333131170.0 238564000.0 False True 492199864.64468396 283429297.9711301 213879685.74747732 1.0 0.5758418852385015 0.43453828639688014 28.874669020152854 -13.999999999999998 0.15357966604361198 3.0631124278022104 0.28529728984032027 0.9995547341581607 0.0050702883149173076 11.972987737679052 0.12359498816385489 7.364899509138186 0.13500826329560545 1.0000000000000041e-14 13.999999999999998 -2.7778151379618903 VHLVGIDIFTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHLVGIDIFTGK 12 0 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 1624262100.0 532510000.0 674799100.0 416953000.0 False True 515605761.53123724 944249899.6608194 307740500.9781215 1.0 1.8313408617789726 0.5968523316422978 28.941693143989507 -6.725267699749335 1.7402284918489277 1.502910834976693 0.5981658153489867 0.5372924179720386 0.3496254649144027 0.3451903575698817 2.045640527387614 0.15934975748091182 0.397590448321882 1.8824883632290015e-07 6.725267699749335 -0.9047450196277064 VHLVGIDIFTGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHLVGIDIFTGK 12 0 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 3656804100.0 1045640000.0 1433694100.0 1177470000.0 False True 1586312326.5236046 1177840186.3518684 944742538.396566 1.0 0.7425020701522879 0.5955589719629579 30.563029702938408 -13.949670273866756 0.06482849703341304 2.552842071983591 6.027471239830444e-14 0.9999430141756755 0.0012618295992973972 12.10980890036047 0.06594821593738694 2.9587124772556104 0.5461518043355266 1.1228706393926258e-14 13.949670273866756 -2.5528420719835307 VHLVGIDIFTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHLVGIDIFTGK 12 0 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 2160284620.0 375435720.0 1018560000.0 766288900.0 False True 514244451.45284367 973556651.2725041 585307244.0352838 1.0 1.8931787178685378 1.1381887395803174 28.937879081675746 -10.169584295753273 4.232671789141759 0.9998542654953916 1.5156837287587968 0.38349506269294786 0.3082233681674976 44210608.15941166 53111187.18809616 51894.90302813042 0.10551306035855006 6.767304280506454e-11 10.169584295753273 0.5158294632634052 VHLVGIDIFTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHLVGIDIFTGK 12 0 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 1262999080.0 532510000.0 345934000.0 384555080.0 False True 442805659.19290006 344070384.87947696 464963769.2462052 1.0 0.7770234587936671 1.0500402594079141 28.722098419423784 -6.689613319395426 1.8679930601691295 0.8601531715740239 1.049086206564036 0.3684806721543774 0.09431145595642823 0.417524820411361 2.8244450525480227 0.040396166722321554 0.1052378357150353 2.0435566462000872e-07 6.689613319395426 0.18893303499001213 VHLVGIDIFTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHLVGIDIFTGK 12 0 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 3388816300.0 1045640000.0 1519586300.0 823590000.0 False True 1353601592.6458628 1435019986.581288 673705070.7470253 1.0 1.0601494519345815 0.4977129713848408 30.334156025030858 -6.880444253268543 1.0773672863482109 1.037498402039724 0.45752010839351687 0.9740399237277093 0.04062774616024943 0.1272350355036665 0.2699409406837581 0.02903832784562418 0.07029914143120276 1.316908942402395e-07 6.880444253268543 -0.5799782936462071 down VHLVGIDIFTGKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHLVGIDIFTGKK 13 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 63579000.0 25367800.0 23651600.0 14559600.0 False True 33257431.46212467 20122873.473214723 13053112.257545002 1.0 0.6050639688194718 0.392487082846749 24.987173414918875 -10.298879686497282 0.12852002096823287 1.8121104197604725 6.931055034920608e-18 0.9998175902720694 0.0033996106691642517 2.0182409408570114 0.06466533107516513 0.7576139640207465 0.23290401064614033 5.02481773812119e-11 10.298879686497282 -1.8121104197604725 VHLVGIDIFTGKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHLVGIDIFTGKK 13 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 75973400.0 22790400.0 28535000.0 24648000.0 False True 22066931.22683424 39929174.30805918 18191949.375849888 1.0 1.8094575044265222 0.8243986981627864 24.39538267707969 -6.6883175231247405 1.872018282638602 1.508256838468377 0.8278323059930132 0.3627747551861028 0.3424582209265257 0.42026997781754016 2.8541043937148887 0.1464056072384356 0.3821138129390963 2.049663072983534e-07 6.6883175231247405 -0.6804245324753638 VHLVGIDIFTGKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHLVGIDIFTGKK 13 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 317053700.0 68198000.0 128011000.0 120844700.0 False True 103461351.94164035 105166436.89549194 96959692.07688648 1.0 1.0164804047294238 0.9371585645969398 26.62451670774196 -6.8524964733059015 1.2229194102843548 1.0088173536958709 0.9338304324172584 0.9438664475916267 0.008097390032891871 0.15473381877563808 0.44404542635100364 0.005177555397995872 0.012002346867923735 1.40444108831412e-07 6.8524964733059015 -0.0749869212786125 VHLVGIDIFTGKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHLVGIDIFTGKK 13 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 96801900.0 25367800.0 33742800.0 37691300.0 False True 34746961.1990182 32251931.52348204 28789391.216690097 1.0 0.928194305647463 0.8285441438114467 25.050383476441766 -6.966518842925487 0.3309795405305995 1.0120027477583524 0.7414688877791547 0.9999410850098038 0.0005395918790047162 0.07744959954556184 0.013064598032881406 0.001449022133037619 0.008684861353882252 1.080142755236941e-07 6.966518842925487 -0.27053385997919777 VHLVGIDIFTGKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHLVGIDIFTGKK 13 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 45217600.0 22790400.0 9116200.0 13311000.0 False True 18951227.38590799 9067089.221175967 16094268.556889785 1.0 0.4784433765972433 0.8492467653497409 24.175787952513968 -10.053145866794209 5.612575478076224 1.000001630231176 0.6638450709733799 0.5228546703264312 0.15137984955682554 3.0879985091054195e-06 5.208758408799902e-07 0.14657361993331988 0.04885763635702101 8.848183753451242e-11 10.053145866794209 -0.3361565592577962 VHLVGIDIFTGKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHLVGIDIFTGKK 13 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 301331000.0 68198000.0 141456000.0 91677000.0 False True 88283655.38355702 133583849.2501823 74992726.68545635 1.0 1.5131209584584386 0.84945198926849 26.39564302983441 -6.700265609443638 1.8298512514646659 1.3185486547942808 0.8514147597460321 0.4188139662950475 0.21658507659325527 0.3950018136774423 2.571506704277267 0.094418512622181 0.24274631651092074 1.9940424088690731e-07 6.700265609443638 -0.46713389504824876 VHLVGIDIFTGKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHLVGIDIFTGKK 13 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 115297000.0 22851000.0 27844000.0 64602000.0 True False 34666637.63187223 22875020.653835047 51833386.38393754 1.0 0.6598569176724522 1.4951950902871047 25.0470445784257 -6.796160219065429 1.4714730336545494 0.8113964389417847 1.5056673241266918 0.8206765590420877 0.14523952907248644 0.22631015212585723 0.9677473781363283 0.07766285267177966 0.1810591915675435 1.5989680316521594e-07 6.796160219065429 0.6942708851849071 VHLVGIDIFTGKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHLVGIDIFTGKK 13 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 28088700.0 7440600.0 12538000.0 8110100.0 True False 10191590.89465444 11984029.702378508 6194661.412752492 1.0 1.1758742895247312 0.6078208472831886 23.280875936194377 -6.823563678650661 1.356513372018216 1.094466642961396 0.594458355231938 0.8923613352395353 0.07790172945475908 0.18888855373733715 0.6819992592889753 0.04511823698582662 0.10389806674465231 1.5011922765304652e-07 6.823563678650661 -0.500008287729458 VHLVGIDIFTGKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHLVGIDIFTGKK 13 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 121261000.0 22851000.0 33568000.0 64842000.0 True False 29581069.96055105 31699911.291356497 53041421.335104376 1.0 1.07162828571215 1.7930866397273582 24.81817090051815 -6.9260780250012965 0.7783060596280065 0.9872883852853803 1.9274188605647546 0.9957098113338003 0.023460448624271074 0.09472588978354018 0.08803427780979196 0.020894509447350936 0.06674245745644028 1.1855557330323469e-07 6.9260780250012965 0.9401304752793743 VHMFEAHSDYIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHMFEAHSDYIR 12 0 P35606-2;P35606;D6R997;D6RBZ7;D6RCL6;D6RBG7;D6RBT6 P35606-2 COPB2 Coatomer subunit beta 0 16263800.0 6456800.0 3392800.0 6414200.0 False True 8464927.327740142 2886607.4650308155 5750520.113351 1.0 0.3410079441049903 0.6793348472710633 23.013066251814973 -10.615357395684011 6.653854015110237 1.001351102836464 0.5101713956882551 0.7364829399184831 0.13812137983548223 0.0027748161766139204 0.000160405135693721 0.13404676096299983 0.04457848365483431 2.4246139766422727e-11 10.615357395684011 -0.4911797071482088 VHMFEAHSDYIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHMFEAHSDYIR 12 0 P35606-2;P35606;D6R997;D6RBZ7;D6RCL6;D6RBG7;D6RBT6 P35606-2 COPB2 Coatomer subunit beta 0 13452200.0 6456800.0 2584400.0 4411000.0 False True 8844053.448459093 2470212.6625320674 3369212.6473966073 1.0 0.2793077492043487 0.3809579698982516 23.076276313337864 -10.819537285499896 7.3782084774549705 1.0312246186158405 0.33013285955133903 0.9830228729925826 0.04149852882356025 0.01740900371205325 0.0004258041858906328 0.03281781179759845 0.013393592585479765 1.5151747157647688e-11 10.819537285499896 -0.7010917590645014 VHMFEAHSDYIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHMFEAHSDYIR 12 0 P35606-2;P35606;D6R997;D6RBZ7;D6RCL6;D6RBG7;D6RBT6 P35606-2 COPB2 Coatomer subunit beta 0 7892200.0 2057700.0 2366900.0 3467600.0 False True 2663733.213330965 2235179.934327683 2836532.3805806134 1.0 0.8391155402280766 1.0648710487915436 21.345018165592883 -6.715364303046235 1.7761335080489182 0.9016366313768874 1.064427378335604 0.49047247522844306 0.06774222732480545 0.36441412253540634 2.2440935404290236 0.03031525544939532 0.0765167473783879 1.9259087085382852e-07 6.715364303046235 0.16279074695871654 VHMTWVQPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHMTWVQPR 9 0 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 0 11962100.0 3192000.0 3272200.0 5497900.0 False True 4184742.911371974 2784000.514935702 4929030.047580751 1.0 0.6652739663815963 1.1778573145284954 21.996707563215306 -6.730486704663541 1.721304896308884 0.7986737018738949 1.1775878102562585 0.5615755926441697 0.14070571440876561 0.33533255984780863 1.946657306449343 0.06477060801107466 0.16064461574643046 1.860001503774008e-07 6.730486704663541 0.3789141083823636 VHMTWVQPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHMTWVQPR 9 0 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 0 8133600.0 3192000.0 2699600.0 2242000.0 False True 4372168.660556537 2580322.7456166106 1712485.775439401 1.0 0.5901699925016523 0.3916788002458755 22.059917624738198 -12.600465365320858 0.10982190704046729 2.4982013097563383 9.511267095693568e-13 0.9997912381446699 0.003659716636238053 7.2123791684292735 0.08592947954868668 2.723302890824925 0.3111056616553609 2.5091962781228695e-13 12.600465365320858 -2.498201309755387 VHPAVVIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHPAVVIR 8 0 P62829;C9JD32;J3KT29;J3KTJ3;J3QQT9 P62829 RPL23 60S ribosomal protein L23 0 21774900.0 4749100.0 8839000.0 8186800.0 False True 6504970.609601827 8448463.753335744 6253246.452438573 1.0 1.2987704726698033 0.9613027986949411 22.633111107977086 -6.673122333932283 1.9271136755919056 1.1901974751298845 0.9626704683990732 0.2926603077823804 0.12682184624111045 0.45395040671135334 3.2533398452994318 0.05293454040024274 0.14081295124969034 2.122646461621513e-07 6.673122333932283 -0.22752700673081128 VHPEGK(ub)FVVDVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHPEGKFVVDVDK 13 1 P62195;J3QRW1;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 52586000.0 13555000.0 19566000.0 19465000.0 True False 17770736.266806718 16646829.067670638 17450948.52146442 1.0 0.9367551697204924 0.9820048117004798 24.083000119718033 -10.050923135695552 4.715822049356372 1.0000013585084415 0.9593799907102164 0.5179457949731154 0.018473088985962623 2.6385761334971074e-07 5.310234507306243e-08 0.01788708973911567 0.005962163832469824 8.893585084695462e-11 10.050923135695552 -0.040621367798225116 VHPEGK(ub)FVVDVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHPEGKFVVDVDK 13 1 P62195;J3QRW1;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 72849770.0 14244770.0 20800000.0 37805000.0 True False 13792577.573542893 29105548.470567044 27902736.37431049 1.0 2.110232718676 2.023025516842761 23.71738875884973 -10.190607625452738 5.5511706237925305 0.99996572899094 2.0666291177594633 0.9950115316417325 0.03560219106485777 1.5101350379566886e-05 2.2017850799107586e-06 0.03447277402020381 0.011490557756847044 6.447515198337093e-11 10.190607625452738 1.0666633887685233 VHPEGK(ub)FVVDVDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHPEGKFVVDVDK 13 1 P62195;J3QRW1;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 121359000.0 31731000.0 51924000.0 37704000.0 True False 48138246.84683113 42657756.51593636 30251787.87374976 1.0 0.88615101941014 0.6284355965435661 25.520680265279474 -6.957553167748397 0.46865140499974123 1.0068969482829033 0.49714865056750346 0.9996683898606237 0.0028304820123483464 0.08058711986366884 0.02445122487236734 0.0035543717697431045 0.02127277656963217 1.1026732327288267e-07 6.957553167748397 -0.5097482977153999 VHPEGK(ub)FVVDVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHPEGKFVVDVDK 13 1 P62195;J3QRW1;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 45796000.0 13555000.0 12551000.0 19690000.0 True False 18566649.810101442 11996455.31939326 15039627.52827912 1.0 0.646129239366944 0.8100345340760724 24.146210181240924 -10.072227598414214 4.718579605130006 1.0000103631816109 0.728081886716413 0.7858528925437698 0.06691405638413303 16719208.700751651 35688637.280388504 1201.0169078192166 0.022906461734656502 8.467835284691906e-11 10.072227598414214 -0.2719284764651978 VHPEGK(ub)FVVDVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHPEGKFVVDVDK 13 1 P62195;J3QRW1;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 62894770.0 14244770.0 27974000.0 20676000.0 True False 11845157.405309292 27823298.50959572 24999256.004977323 1.0 2.348917583579314 2.1105043309742797 23.497794034284006 -10.179712246031746 4.462936393836037 0.9997333383939907 2.2297109573042007 0.9725816057262351 0.09733180289954184 34143030.241379924 47.76872583742059 94199.57326435055 0.03331926499182691 6.611313540069235e-11 10.179712246031746 1.22997761891021 VHPEGK(ub)FVVDVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHPEGKFVVDVDK 13 1 P62195;J3QRW1;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 118757000.0 31731000.0 64959000.0 22067000.0 True False 41076405.011520095 61343974.54644985 18051032.42654066 1.0 1.4934114737948856 0.43945015201496224 25.291806587371923 -6.779383630086518 1.5381301214474727 1.2795994744817931 0.43123920312327496 0.7652710866699496 0.2086055497635053 0.25152149557807313 1.1752977214033158 0.1068213816097165 0.2521987349853992 1.6619439386939076e-07 6.779383630086518 -0.8483602713585181 down VHPEGK(ub)FVVDVDKNIDINDVTPNCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHPEGKFVVDVDKNIDINDVTPNCR 25 2 P62195;J3QRW1;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 129262000.0 22138000.0 58687000.0 48437000.0 True False 33584964.50459008 48213846.32637608 38863405.7193087 1.0 1.435578302302111 1.157166794504047 25.001312168362777 -10.107255575910406 4.560602361977367 0.9999748684013806 1.2963725484076192 0.6017389665490508 0.11366102213370491 79174730.09851712 1.5197997305242024 20903.128860689347 0.0389091910778951 7.81167963447916e-11 10.107255575910406 0.29639768000623856 VHPEGK(ub)FVVDVDKNIDINDVTPNCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHPEGKFVVDVDKNIDINDVTPNCR 25 2 P62195;J3QRW1;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 103618000.0 22138000.0 54269000.0 27211000.0 True False 28658077.405219886 51248882.44371504 22258877.20843783 1.0 1.7882875295179566 0.7767051813595673 24.772438490455226 -6.698719612838966 1.8351129473022758 1.4900918077292507 0.779750905410984 0.411682943762264 0.3328223719116116 0.39817361054156825 2.605935439193211 0.14472716890564113 0.3728341152360451 2.0011534279282285e-07 6.698719612838966 -0.7103409023182666 VHPK(ub)LNQMDQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHPKLNQMDQDK 12 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 3755100.0 1088400.0 1317000.0 1349700.0 True False 1426902.9400805938 1120508.7336257917 1210045.9912366066 1.0 0.7852732671239038 0.848022635070232 20.444455773355276 -9.919965602473884 6.103451606388328 1.0000000469189287 0.8166479510970278 0.9192500735856982 0.02561732219191956 1.635663870906717e-08 2.876456507127266e-09 0.02480387202397292 0.008267955185290186 1.2023596616160897e-10 9.919965602473884 -0.18335209582190093 VHPK(ub)LNQMDQDK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VHPKLNQMDQDK 12 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 7390960.0 1588170.0 2680800.0 3121990.0 True False 1537754.4126703052 3751257.4201873117 2304247.161307593 1.0 2.4394385665740126 1.4984493897866797 20.55239368516388 -10.534544197745172 5.400900518640913 0.9970323123870983 1.9689439781803484 0.5857036459291127 0.3841572227684346 0.013750799399277452 0.0011850577680189312 0.3725867970157505 0.12398621050895213 2.920490529480235e-11 10.534544197745172 0.9719116657932501 VHPK(ub)LNQMDQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHPKLNQMDQDK 12 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 4687800.0 1088400.0 1495600.0 2103800.0 True False 1490810.8929040518 1429519.4467121789 1606925.76912106 1.0 0.9588871757755411 1.0778870591633658 20.507665834878168 -6.813387477548687 1.4000223872063535 0.9776821229644581 1.0801389801569932 0.868557355033318 0.01789137306063099 0.20220466867472212 0.7804353001206485 0.010046179310471068 0.023207752889892123 1.5367829107102758e-07 6.813387477548687 0.10245685719253506 VHPK(ub)LNQMDQDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHPKLNQMDQDK 12 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 2511670.0 753460.0 1135800.0 622410.0 True False 626535.3739375452 1129681.2199613522 752553.0533013126 1.0 1.8030605564402848 1.2011341810946643 19.257036440270575 -10.471219010418743 5.538346790946966 0.999408144837806 1.5020973687674755 0.48125876454022254 0.24573541371996338 0.001797843088110969 0.00017165163544590305 0.2381990846250244 0.07931076374256671 3.378943964264963e-11 10.471219010418743 0.5026892239296694 VHPVSTMIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHPVSTMIK 9 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 7401230.0 520530.0 4108100.0 2772600.0 False True 682419.8708196904 3495187.49324838 2485717.948657196 1.0 5.121755157935431 3.6425052302059573 19.38030013034807 -9.694041788681973 9.32044500943361 1.0000376445177661 4.382130194070694 0.874530366735684 0.6039012545554497 0.0 0.0 0.5847248752350384 0.19490829174501273 2.0228245290995491e-10 9.694041788681973 3.3820925495529277 VHPVSTMIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHPVSTMIK 9 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 4604640.0 1913500.0 707840.0 1983300.0 False True 1852756.9898969433 990484.2033368348 1463814.2322753593 1.0 0.534600170846976 0.7900735176051241 20.821242237272486 -10.100475369176076 5.287226667883388 1.0000059223362094 0.6623368442257417 0.6996314620211093 0.10429655707417643 7.281007566183563e-06 1.2389440427732987e-06 0.10098647777258225 0.03366156905109881 7.934592561999893e-11 10.100475369176076 -0.33766907811046776 VHPVSTMIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHPVSTMIK 9 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 83743200.0 2229600.0 80229000.0 1284600.0 False True 3382466.2055937317 65911508.11796199 1030698.2469398177 1.0 19.486228128151364 0.3047179733045986 21.68964408955233 -6.4973427367062095 2.6297699195901374 9.999999999999998 0.27784952700930643 0.27680516268001243 7.554101026202243 0.5825441500183757 7.530316246507545 2.9381455749668746 9.990984615296265 3.1816856066624797e-07 6.4973427367062095 -9.722150472990691 VHPVSTMIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHPVSTMIK 9 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 7835330.0 520530.0 3032600.0 4282200.0 False True 712984.0077943271 2898609.7045328673 3270832.554677347 1.0 4.065462440735449 4.587525833568033 19.44351019187096 -9.79311073133236 0.4579327192157634 1.3684669258924152e-22 4.602885976616902 0.9988021591253884 0.05477152062086799 1.0921390203747992 0.20197711761036333 1.754331257172319 0.11483854376752682 1.610235023922906e-10 9.79311073133236 4.602885976616902 VHPVSTMIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHPVSTMIK 9 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 5710800.0 2229600.0 1928500.0 1552700.0 False True 2886261.15198655 1821177.2797122553 1270124.5320473851 1.0 0.6309814614172314 0.4400587698632836 21.46077041164478 -12.197050659323967 0.10112617669910538 2.3208975648738783 2.8720110730506106e-13 0.9998463988051675 0.002880480452138192 6.124779326063204 0.07586690636990884 2.0479923173970658 0.3341397069411816 6.352568264699275e-13 12.197050659323967 -2.320897564873591 VHSFPTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHSFPTLK 8 0 P07237;H7BZ94;H0Y3Z3;I3L0S0 P07237 P4HB Protein disulfide-isomerase 0 23913800.0 2071800.0 11732000.0 10110000.0 False True 2716149.86333974 9981631.330977831 9063914.18196792 1.0 3.6749192177137666 3.3370449489201075 21.37313165168014 -9.73043172011799 6.566483331590346 0.9999999892945334 3.505982083318172 0.986549621283765 0.13793659263117564 2.2907154936991288e-08 4.8492254539776295e-09 0.13355653052624247 0.044518843840440074 1.8602370071387934e-10 9.73043172011799 2.5059820940236386 VHSFPTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHSFPTLK 8 0 P07237;H7BZ94;H0Y3Z3;I3L0S0 P07237 P4HB Protein disulfide-isomerase 0 22252900.0 8354600.0 2122300.0 11776000.0 False True 8089387.796076831 2969745.4576482917 8691512.327572562 1.0 0.3671162184966025 1.074433881360929 22.94759909311858 -6.670833039158395 1.9348250914976588 0.5963185557454925 1.0715620995317718 0.28263653378365483 0.26878415545092826 0.4591644258500493 3.314802261416884 0.11181696382267498 0.2983786969300872 2.1338651018757375e-07 6.670833039158395 0.4752435437862793 VHSFPTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHSFPTLK 8 0 P07237;H7BZ94;H0Y3Z3;I3L0S0 P07237 P4HB Protein disulfide-isomerase 0 24398800.0 2071800.0 10272000.0 12055000.0 False True 2837800.448289796 9818149.075038444 9207857.280518282 1.0 3.4597743054679424 3.2447162682166075 21.43634171320303 -9.807413799730657 7.441947706990039 0.9999999994914576 3.3522452868422845 0.993769925265575 0.08779707605840532 4.39147296784772e-09 1.0212931858256304e-09 0.08500915272159443 0.028336384451654057 1.5580672547152228e-10 9.807413799730657 2.352245287350827 VHTDYYAK(ub)YDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHTDYYAKYDR 11 1 A0A0J9YWJ4;K7EJD2;A0A0J9YWB6;A0A0A0MR03;Q9Y5B0-4;Q9Y5B0 A0A0J9YWJ4 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 1 11617900.0 4046700.0 1673500.0 5897700.0 True False 6139139.753397979 1374850.8498848213 4732017.009946264 1.0 0.22394845289583923 0.7707948018819933 22.549605081523 -10.061123645426292 6.708924847990826 1.000000252578329 0.49737162739540486 0.5297270222145147 0.2232490871200055 8.434272091929381e-07 1.1786760519629363e-07 0.21616011024033022 0.07205333303931546 8.687130678900412e-11 10.061123645426292 -0.5026286251829241 VHTDYYAK(ub)YDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHTDYYAKYDR 11 1 A0A0J9YWJ4;K7EJD2;A0A0J9YWB6;A0A0A0MR03;Q9Y5B0-4;Q9Y5B0 A0A0J9YWJ4 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 1 14768500.0 4046700.0 4063800.0 6658000.0 True False 5238532.92238247 3837645.9576326967 5446312.316849031 1.0 0.7325802881252765 1.039663661094653 22.32073140361545 -6.676557562686899 1.9144892353176293 0.8302746581973196 1.038454490118302 0.3082523179063219 0.11342612180990724 0.4462319393482163 3.1592259655732544 0.047596481943802976 0.1260717704364094 2.1059227552047173e-07 6.676557562686899 0.20817983192098233 VHVGDEDFVHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHVGDEDFVHLR 12 0 P04080 P04080 CSTB Cystatin-B 0 103186100.0 8265100.0 58248000.0 36673000.0 False True 10835626.139342269 49557625.44892567 32878429.752256073 1.0 4.573582071920198 3.0342897890210727 23.36927918654243 -9.132132308396265 10.820560730999388 1.000002643964105 3.8039359304708107 0.8156403142375243 0.6284134430202821 0.0 0.0 0.608458690769759 0.20281956661215864 7.376794608557914e-10 9.132132308396265 2.8039332865067057 VHVGDEDFVHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHVGDEDFVHLR 12 0 P04080 P04080 CSTB Cystatin-B 0 95872400.0 27782000.0 9267400.0 58823000.0 False True 26900075.617097914 12967921.148852542 43415491.64782615 1.0 0.4820774979758801 1.6139542604196584 24.681106892467742 -6.782292387549937 1.5268516567634576 0.7076051378848013 1.6235843634111655 0.7754140702204152 0.21924777710286364 0.24704726453097656 1.137697049043668 0.11307885917544058 0.266321755553109 1.650849993852545e-07 6.782292387549937 0.9159792255263642 VHVGDEDFVHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHVGDEDFVHLR 12 0 P04080 P04080 CSTB Cystatin-B 0 197300100.0 8265100.0 72115000.0 116920000.0 False True 11320930.825929152 68928720.8475854 89305904.04298621 1.0 6.088608958700898 7.888565473648368 23.43248924806532 -9.010751413304854 0.41540169363362117 3.76057268311071e-14 8.151470302011825 0.9974173025368507 0.1482485805184885 0.4701284697511739 0.15406302620975013 1.290875270752345 0.433811209970397 9.755478737538788e-10 9.010751413304854 8.151470302011788 VHVGDEDFVHLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHVGDEDFVHLR 12 0 P04080 P04080 CSTB Cystatin-B 0 38881700.0 27782000.0 6429900.0 4669800.0 False True 23101963.951281913 6395260.852464778 5646233.589284348 1.0 0.27682758340162283 0.24440491731314656 24.46151216790202 -13.397601705766492 0.4487679812949802 9.999754391877909 0.24441183127996216 0.9998884704519739 0.003683587762918561 20.077533274985917 0.22726626093297045 175.5376117544794 0.007342526570986236 4.0031170988164264e-14 13.397601705766492 -9.755342560597947 VHVGDEDFVHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHVGDEDFVHLR 12 0 P04080 P04080 CSTB Cystatin-B 0 20313100.0 2958200.0 10109000.0 7245900.0 False True 3829448.214839702 9546425.263474818 5927220.549212437 1.0 2.492898383239901 1.5478001572768485 21.868705098533514 -10.004016158690586 5.282264817611307 0.9999944063162955 2.020349270261465 0.6084746247096351 0.3858347350806586 2.541707171490186e-05 4.793051768410426e-06 0.3735849226446177 0.12452762527808539 9.907950799321457e-11 10.004016158690586 1.0203548639451696 VHVIFNYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHVIFNYK 8 0 P27797;K7EJB9 P27797 CALR Calreticulin 0 2296537300.0 542927600.0 660357200.0 1093252500.0 False True 711783341.318358 561834479.8122052 980133218.5184845 1.0 0.7893335614901875 1.3770106177296755 29.406862927295528 -6.809792225535141 1.4156924808297104 0.8851614678979743 1.3872146235240093 0.8592078756930648 0.09121692756786764 0.20708973681212572 0.8181053378231532 0.050667524732610755 0.11719986991541922 1.5495577785367804e-07 6.809792225535141 0.5020531556260349 VHVIFNYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHVIFNYK 8 0 P27797;K7EJB9 P27797 CALR Calreticulin 0 2023324300.0 639885800.0 447150000.0 936288500.0 False True 619572975.5347791 625699326.8564447 691046453.7970799 1.0 1.0098880221758828 1.1153592572377922 29.20669897728669 -6.925165516306058 0.7854673286070301 0.9980765959490007 1.1345667859621682 0.9954994799977044 0.003502319290766004 0.09522754885365217 0.09055798406964435 0.003103319271207999 0.009809260341575074 1.1880493572635693e-07 6.925165516306058 0.13649019001316753 VHVIFNYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHVIFNYK 8 0 P27797;K7EJB9 P27797 CALR Calreticulin 0 1761952500.0 544747300.0 553060000.0 664145200.0 False True 826421480.4621586 454362121.9224966 532876610.114818 1.0 0.5497946661168637 0.6448000478119447 29.622302512519543 -10.014365967381849 5.831468796276648 1.0000007199301708 0.5972973569643388 0.9599292073643401 0.03878578466217816 3.6305238729760067e-07 6.132009037304422e-08 0.037554241664987505 0.01251805817214058 9.674622602429066e-11 10.014365967381849 -0.402703362965832 VHVIFNYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHVIFNYK 8 0 P27797;K7EJB9 P27797 CALR Calreticulin 0 2361789900.0 542927600.0 724838900.0 1094023400.0 False True 743662605.786709 692813120.6762928 835637605.0391841 1.0 0.9316229097513605 1.1236783973495295 29.47007298881842 -6.810427694651383 1.412569157408788 0.9627543466528683 1.1270769291254068 0.860994763388974 0.02963374949753544 0.20620825996566258 0.8108421001700158 0.016494692235395694 0.038151222258075816 1.5472920899545495e-07 6.810427694651383 0.1643225824725385 VHVIFNYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHVIFNYK 8 0 P27797;K7EJB9 P27797 CALR Calreticulin 0 1466235100.0 639885800.0 377873800.0 448475500.0 False True 532093394.4473839 375838118.83732307 542249653.533576 1.0 0.70633862919433 1.0190873617154 28.987104252720965 -11.045532814170747 12.34941864106858 1.501110174077231 0.8627129954487407 0.2044076241199173 0.12767913539646678 0.04149655144722914 0.00015299969772321912 0.0029121729263289205 0.04120826375405645 9.004657233130263e-12 11.045532814170747 -0.6383971786284903 VHVIFNYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHVIFNYK 8 0 P27797;K7EJB9 P27797 CALR Calreticulin 0 2460829200.0 544747300.0 1324701900.0 591380000.0 False True 705186118.4246329 1250981074.7584436 483754908.0712199 1.0 1.773972915906374 0.6859960731386993 29.393428834611992 -6.715594466574409 1.7746594101516369 1.4730443987393393 0.6880315879851346 0.4919794801886954 0.3258752810233063 0.36389747027431835 2.2371886829490415 0.14592626691907432 0.3683117716413018 1.9248883029809526e-07 6.715594466574409 -0.7850128107542047 VHVTVDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VHVTVDLK 8 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 24767400.0 11402000.0 5978300.0 7387100.0 False True 14948132.417125085 5086360.94323088 6622753.75406678 1.0 0.34026731910695235 0.44304890867032526 23.833461913126023 -10.051644194809617 5.444292406579235 1.0000038220879903 0.39165811389212246 0.9790397330675946 0.04196040823259004 2.128173927313355e-06 3.7074523035954126e-07 0.04062826954771528 0.013542663523421176 8.878831316900202e-11 10.051644194809617 -0.6083457081958679 VHVTVDLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VHVTVDLK 8 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 85487000.0 18599000.0 33324000.0 33564000.0 False True 28216042.7690338 27377071.83839962 26930060.688376203 1.0 0.9702661731305948 0.9544237265592423 24.750012331883994 -13.999999233649298 0.0782353399677379 1.162102149673956 0.9055305758379433 0.9998937713336151 0.00019463249742180609 12.275982154753443 0.07818258192358779 0.3472530087406659 0.04450227231185676 1.0000017645892594e-14 13.999999233649298 -0.2565715738360128 VHVTVDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHVTVDLK 8 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 31510800.0 11402000.0 8755800.0 11353000.0 False True 15617627.52746418 8368939.804441358 8671655.222374452 1.0 0.5358649890788 0.5552479214352515 23.896671974648914 -10.579747689923916 9.94247892950492 1.000030139094539 0.545556455265738 0.9986374626018752 0.00791304899869802 5.2868774492114e-06 2.234655236585493e-07 0.007662281281149517 0.0025539255824733897 2.6317965306150884e-11 10.579747689923916 -0.45447368382880093 VHVTVDLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VHVTVDLK 8 0 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 0 87181000.0 18599000.0 47534000.0 21048000.0 False True 24076772.141100556 44888691.11425585 17217479.970717683 1.0 1.8643982196279563 0.7151074849159854 24.521138653976443 -6.705483015998745 1.8115718035210002 1.5338456544606822 0.7181736633855077 0.4435791288441593 0.3645193666248569 0.3841882127369825 2.45489205853113 0.160311468019666 0.40947230147014135 1.9702302557177894e-07 6.705483015998745 -0.8156719910751745 VHYENNSPFLTITSMTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VHYENNSPFLTITSMTR 17 0 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 14625300.0 5521300.0 2992900.0 6111100.0 False True 5346029.353706818 4187980.5777673163 4510419.580929747 1.0 0.7833815156408491 0.8436952516548234 22.350036328403668 -10.047373372709501 5.537945358533978 1.0000009885421737 0.8135383836477371 0.9272377742323963 0.024622979619543087 3.005327457160386e-07 5.170557140181782e-08 0.023841223969228057 0.007947032499990543 8.966575863922343e-11 10.047373372709501 -0.18646260489443656 VHYENNSPFLTITSMTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VHYENNSPFLTITSMTR 17 0 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 25903300.0 10233000.0 5492300.0 10178000.0 False True 14016416.636427011 5249632.025392687 7774166.022489851 1.0 0.37453453058390923 0.5546471843799015 23.74061422885041 -10.90774851616386 11.442499909119444 1.0471083819272897 0.46459085748190543 0.9217654520512253 0.07353068300312343 0.03785547662514867 0.0003051970836175571 0.030499529805076656 0.023731925892196144 1.2366633320445641e-11 10.90774851616386 -0.5825175244453843 VHYENNSPFLTITSMTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VHYENNSPFLTITSMTR 17 0 P04843;B7Z4L4 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 11112800.0 5521300.0 2560300.0 3031200.0 False True 4591205.585062736 2546507.1557202423 3665009.905314725 1.0 0.5546489061620721 0.7982674348625678 22.130441603837944 -10.092780439473032 5.231974946223347 1.0000057993647637 0.6764581705118953 0.7016425236552463 0.09945684786878313 6.728060979599384e-06 1.1667769444245873e-06 0.09630040466279252 0.03209955962162634 8.076432365817272e-11 10.092780439473032 -0.3235476288528685 VIACFDSLK(ub)GR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIACFDSLKGR 11 1 Q9NR56;C9JP00;A0A0A0MQX8;Q9NR56-6;Q9NR56-7;Q9NR56-4;H7C4T5;Q9NR56-3;Q9NR56-2;Q9NR56-5;Q5VZF2-3;Q5VZF2-2;O95205;Q5VZF2 Q9NR56 MBNL1;MBNL2;MBLL Muscleblind-like protein 1;Muscleblind-like protein 2 1 24260500.0 4684800.0 4810700.0 14765000.0 True False 6064565.951213928 4542980.316054835 12077921.501693593 1.0 0.7491023022258466 1.9915558011659495 22.531972962825012 -6.854148488913245 1.2148754713689291 0.8654743554274593 2.045353789499868 0.9461326828310922 0.12450204398086868 0.15295019353458916 0.4323204222602238 0.0800971307249514 0.18591312808476912 1.3991088737666044e-07 6.854148488913245 1.1798794340724088 VIADNVK(ub)DWSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIADNVKDWSK 11 1 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 1 13809500.0 5367800.0 6106100.0 2335600.0 True False 7037237.781849148 5195093.681391381 2093934.5166571944 1.0 0.7382290953406275 0.29755062732965937 22.746577830513658 -6.9801991930616225 0.3902344654617256 1.0272921502399097 1.5769368180960726e-10 0.9998738023907296 0.0032561883002825017 0.07628175368812806 0.01698322667325375 0.005640488204298511 0.03601679794331801 1.0466483832694302e-07 6.9801991930616225 -1.027292150082216 down VIADNVK(ub)DWSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIADNVKDWSK 11 1 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 1 18418400.0 8600600.0 5470300.0 4347500.0 True False 8327578.660730419 7654619.317237645 3208759.327795657 1.0 0.9191890739301948 0.3853172042585322 22.989465645712208 -6.93383321495375 0.7146279111198011 1.007078617156399 0.26418983278977726 0.9972394281055942 0.014329006280258056 0.09069578629362725 0.06828400509118247 0.013365965506680236 0.047329402082381594 1.1645731824565977e-07 6.93383321495375 -0.7428887843666218 down VIADNVK(ub)DWSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIADNVKDWSK 11 1 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 1 36574600.0 12707000.0 8978600.0 14889000.0 True False 19277448.00613543 7376298.679878013 11946182.623919485 1.0 0.3826387537152407 0.6196973074505181 24.200410741060463 -10.246009569365482 5.5520340487300075 1.0000324917973358 0.5011680305828802 0.8551534886203438 0.09677874930233184 3.8925712890517774e-05 5.286158671778111e-06 0.09371170815889297 0.03123520702621613 5.6753210011053255e-11 10.246009569365482 -0.4988644612144556 VIADNVK(ub)DWSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIADNVKDWSK 11 1 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 1 15096400.0 5367800.0 4713100.0 5015500.0 True False 7352420.719340657 4504859.657862513 3830942.1974649024 1.0 0.6127042820077488 0.5210450195522067 22.80978789203655 -13.999999999999961 0.20244479950901453 3.173238088048083 0.4629309856121 0.9994871975899134 0.004700627301247423 12.580315630350187 0.1426572813006345 10.83707267527085 0.05731758269793838 1.00000000000009e-14 13.999999999999961 -2.710307102435983 VIADNVK(ub)DWSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIADNVKDWSK 11 1 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 1 16737300.0 8600600.0 5200800.0 2935900.0 True False 7151779.971182613 5172782.258122029 3549783.115932137 1.0 0.7232859901961807 0.49634959831477415 22.769870921146484 -7.040284019246651 0.16179549719017824 1.228727050182593 4.4014457368576914e-13 0.9999980494207934 0.00028757672822031494 0.0722096704538345 0.005067339834649752 0.010716599484740071 0.026741001928096524 9.114145988757595e-08 7.040284019246651 -1.228727050182153 down VIADNVK(ub)DWSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIADNVKDWSK 11 1 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 1 33502000.0 12707000.0 12402000.0 8393000.0 True False 16449461.992417067 11711817.797765836 6865560.1194523815 1.0 0.7119878937782155 0.41737292822204713 23.971537063152912 -6.970842383968844 0.23721366271328123 1.1095115781213698 0.01135725423821162 0.9999882253251896 0.0008161837181316605 0.07603036286313473 0.008046027578697592 0.007183499128100526 0.028866519703987376 1.0694429356550594e-07 6.970842383968844 -1.0981543238831581 down VIAHSEYQK(ub)SK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIAHSEYQKSK 11 1 P49914 P49914 MTHFS 5-formyltetrahydrofolate cyclo-ligase 1 2509970.0 475760.0 584110.0 1450100.0 True False 651661.3289305686 558302.0888065337 1107616.245746956 1.0 0.8567365654837225 1.699680795183363 19.31376285911733 -6.863143727703981 1.1696753028052829 0.9215159561359048 1.7430350263089598 0.9573526217568217 0.07605318311126436 0.14360255228261087 0.37154722501708004 0.05064236565274336 0.11867084399340236 1.3704281543949565e-07 6.863143727703981 0.821519070173055 VIAHTQMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIAHTQMR 8 0 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2 P39023 RPL3 60S ribosomal protein L3 0 2120980.0 376890.0 1344900.0 399190.0 False True 494106.43980795145 1144246.1623791412 357885.64810086734 1.0 2.3157888062011196 0.7243088113564555 18.91446233333588 -6.687149411388846 1.8763761775183931 1.8271315696330999 0.7299779775016375 0.35706595483944614 0.5568170754721354 0.42289790631007046 2.8844547475585722 0.2375856226563599 0.62096031003716 2.0551834245847805e-07 6.687149411388846 -1.0971535921314624 VIAHTQMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIAHTQMR 8 0 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2 P39023 RPL3 60S ribosomal protein L3 0 2232050.0 376890.0 1064100.0 791060.0 False True 516236.41806928284 1017084.5434918639 604227.9203921029 1.0 1.9701913849777322 1.1704480723229622 18.97767239485877 -10.166913470698736 4.485408580569252 0.9999091634598649 1.570319728570995 0.40407717055407566 0.3264938403418101 37273089.12907641 84485625.13670829 23306.08958405505 0.1117675395790505 6.809050094286028e-11 10.166913470698736 0.5704105651111302 VIAINVDDPDAANYNDINDVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIAINVDDPDAANYNDINDVK 21 0 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 5752400.0 0.0 3068700.0 2683700.0 False True 0.0 2610861.9216989144 2406016.4678681786 0.0 VIAINVDDPDAANYNDINDVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIAINVDDPDAANYNDINDVK 21 0 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 13217800.0 3441500.0 2550700.0 7225600.0 False True 3332251.4662818583 3569207.8117247815 5332998.596646423 1.0 1.0711099830972002 1.6004190111729497 21.668065846218695 -6.931462659204404 0.734682452534185 0.9923720126780005 1.7132465634927336 0.9968181051436243 0.015109368836094818 0.09188514392562241 0.07401011211936027 0.01388719180463329 0.04751385645125952 1.170947276459732e-07 6.931462659204404 0.7208745508147332 VIAINVDDPDAANYNDINDVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIAINVDDPDAANYNDINDVK 21 0 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 9323700.0 0.0 3161400.0 6162300.0 False True 0.0 3021718.894648222 4706891.656552281 0.0 VIAINVDDPDAANYNDINDVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIAINVDDPDAANYNDINDVK 21 0 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 7067200.0 3441500.0 1859300.0 1766400.0 False True 2861759.734300511 1849283.581857844 2135746.073089183 1.0 0.6462050463890036 0.7463051658357389 21.44847112165297 -10.224812281338195 7.834518822320996 1.0000002566174668 0.6962551061123718 0.924681019200251 0.040865702639358195 1.8317195298397462e-07 1.8137197077697732e-08 0.03956808004525081 0.013189348812774896 5.959196671089335e-11 10.224812281338195 -0.303745150505095 VIAINVDDPDAANYNDINDVKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIAINVDDPDAANYNDINDVKR 22 1 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 18056800.0 4113400.0 7050600.0 6892800.0 False True 5392707.234222262 5998677.963023541 6179599.176406374 1.0 1.1123685567345047 1.1459177937920448 22.362578282534674 -13.999999999999998 0.16940146271211587 0.43420464504204165 1.1757014174222018 0.9995148247420133 0.0013744615685640793 12.085922594087371 0.1303254730277204 2.2469461481435693 0.02750247756614848 1.0000000000000041e-14 13.999999999999998 0.7414967723801602 VIAINVDDPDAANYNDINDVKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIAINVDDPDAANYNDINDVKR 22 1 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 21118700.0 6122800.0 3399900.0 11596000.0 False True 5928435.065451275 4757497.800244274 8558659.727456799 1.0 0.8024879665072507 1.4436625573135649 22.49921989479137 -6.823988456109357 1.3544628089251958 0.8939491339611911 1.4589021081108249 0.8933261975016165 0.08756766537412486 0.1883481207209403 0.6778354058096685 0.050788978222651826 0.11695861591441394 1.4997246988406125e-07 6.823988456109357 0.5649529741496337 VIAINVDDPDAANYNDINDVKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIAINVDDPDAANYNDINDVKR 22 1 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 26873400.0 4113400.0 11035000.0 11725000.0 False True 5634235.140455277 10547437.212134855 8955796.483954944 1.0 1.872026450653702 1.5895318993078564 22.425788344057565 -10.153967804879928 5.034941680254282 0.9999598164706852 1.7307791749820007 0.8992198551636543 0.11532791765655961 5.202552457891278e-05 8.742166991080462e-06 0.11167189151626575 0.03722192536910918 7.01507300634131e-11 10.153967804879928 0.7308193585113155 VIAPWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIAPWR 6 0 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 0 7358700.0 1451400.0 3129300.0 2778000.0 False True 1902799.4553775936 2662420.6379158595 2490559.2084576506 1.0 1.3992124237745935 1.308892117568649 20.859692086806678 -10.140666900185542 4.565516997707767 0.9999577558681896 1.3540522706787697 0.9534627169386478 0.03687311062711595 1.5857004265118417e-05 2.984611465378736e-06 0.03570648831027871 0.011900745278375506 7.233243739440556e-11 10.140666900185542 0.3540945148105801 VIASMTVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIASMTVGK 9 0 Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 Q10567-3 AP1B1 AP-1 complex subunit beta-1 0 12782100.0 4385500.0 4386600.0 4010000.0 False True 5749432.969242409 3732136.3788328795 3595083.666636132 1.0 0.6491312097729622 0.6252936047552267 22.454988248372423 -13.999999999999998 0.3820045937876057 6.27233254934618 0.6232724066386846 0.9998107298217074 0.002356611301699587 24.290413001564573 0.20176315230507935 105.40615834826306 0.00642244520127574 1.0000000000000041e-14 13.999999999999998 -5.649060142707495 VIASMTVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIASMTVGK 9 0 Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 Q10567-3 AP1B1 AP-1 complex subunit beta-1 0 7579300.0 2201400.0 1111700.0 4266200.0 False True 2131517.7619854356 1555607.607438913 3148754.2367433757 1.0 0.7298121719567179 1.4772357485824652 21.023449646686327 -6.8089137550834975 1.4191099196813695 0.8525614887568197 1.489987955219169 0.8569750737737034 0.1168642389265194 0.20828131939671618 0.8269096629785582 0.06475676839971266 0.14986972080674468 1.5526953232994256e-07 6.8089137550834975 0.6374264664623494 VIASMTVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIASMTVGK 9 0 Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 Q10567-3 AP1B1 AP-1 complex subunit beta-1 0 10891900.0 4385500.0 2755400.0 3751000.0 False True 6006937.8636812875 2633657.3171106866 2865091.054269939 1.0 0.43843591807967824 0.4769636575721292 22.518198309895315 -9.948239328302186 5.935374033211108 1.000000310203612 0.4576997897478043 0.9962287276949465 0.015728883783835086 6.457996480707784e-08 1.1393898119847509e-08 0.015229435087270513 0.005076475412346988 1.1265764583349926e-10 9.948239328302186 -0.5423005204558076 VIASMTVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIASMTVGK 9 0 Q10567-3;Q10567-4;Q10567-2;Q10567;C9J1E7 Q10567-3 AP1B1 AP-1 complex subunit beta-1 0 6048700.0 2201400.0 1834400.0 2012900.0 False True 1830561.6385556124 1824517.7231001067 2433788.08340196 1.0 0.9966983272629516 1.3295308019905396 20.803854922120603 -6.90465886206865 0.9313301843740656 0.9878744729773542 1.3679717940443747 0.9887452395789317 0.016563201314740785 0.1080575750796947 0.15870541815967965 0.013212109009709934 0.03525368298228829 1.24549256093683e-07 6.90465886206865 0.38009732106702054 VIATFTCSGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIATFTCSGEK 11 0 P49189;P49189-3 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 15964800.0 5384300.0 5970400.0 4610100.0 False True 7058869.441635368 5079639.592436917 4133091.075201808 1.0 0.7196109284123674 0.5855174273125912 22.751005707274622 -13.999999999425935 0.09772002654787622 2.3944772580470177 0.2895424628684815 0.9998050829216251 0.002410957627217699 12.098134451211264 0.09262546049592021 3.4226546281886088 0.264337036709381 1.0000000013218341e-14 13.999999999425935 -2.1049347951785364 VIATFTCSGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIATFTCSGEK 11 0 P49189;P49189-3 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 13612000.0 5384300.0 3337300.0 4890400.0 False True 7375021.2152363835 3189847.0510247126 3735388.240949533 1.0 0.43252038983083413 0.5064918638108361 22.814215768797514 -10.559451112475235 6.366097399375398 1.0008319615307308 0.4695061268212199 0.9856271876898678 0.030198727795427933 0.00035709410565754637 2.4711722448720694e-05 0.02928127685017822 0.009746597485695282 2.7577118641173914e-11 10.559451112475235 -0.5313258347095109 VIATFTCSGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIATFTCSGEK 11 0 P49189;P49189-3 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 3663000.0 1323100.0 1031800.0 1308100.0 False True 1100216.2732683434 1026241.4886037359 1581617.6620289616 1.0 0.9327634152830195 1.4375515982240012 20.06935571644015 -6.873329600374725 1.1162827804588442 0.9610856402768247 1.4690536007785309 0.9678971332953809 0.04009909241040798 0.13370491699811066 0.3093646090970546 0.027817225005281377 0.06626922329847854 1.3386603484151186e-07 6.873329600374725 0.5079679605017061 VIATFTCSGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIATFTCSGEK 11 0 P49189;P49189-3 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 9953900.0 2879000.0 4258100.0 2816800.0 False True 3726922.2535743085 4021132.991829269 2304171.3028087034 1.0 1.0789420111924248 0.618250434550623 21.82955329299177 -6.862763158624612 1.1717867136886513 1.04318227509024 0.5947448343167159 0.9569062374676168 0.041759635051512124 0.14397721676861028 0.37411092400229684 0.027764102811536996 0.06502073984581831 1.371629576889458e-07 6.862763158624612 -0.4484374407735241 VICAEEPYICK(ub)DFPETNNILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VICAEEPYICKDFPETNNILK 21 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 38545300.0 12607000.0 20022000.0 5916300.0 True False 16527899.08636167 17034795.64514474 5304138.029156951 1.0 1.030669146522158 0.320920281606376 23.97840001495684 -6.896801309942127 0.9812779213160839 1.0321540039062176 0.2510785004652979 0.9849063079425059 0.04024644951996612 0.11379790599192893 0.19100002817748424 0.030936837738954472 0.07927444615562393 1.2682319502411232e-07 6.896801309942127 -0.7810755034409197 down VICAEEPYICK(ub)DFPETNNILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VICAEEPYICKDFPETNNILK 21 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 121338000.0 39171000.0 30629000.0 51538000.0 True False 59425270.783688486 25163015.64453071 41351491.71009216 1.0 0.42343964634381864 0.6958570178100499 25.824573236336242 -10.44783004122055 6.157949343026013 1.0001752124695027 0.5596483320769455 0.7769809584088125 0.1112139261937482 0.0002676284020520461 2.399761320970767e-05 0.10772459907544532 0.03589414033456061 3.565906559342653e-11 10.44783004122055 -0.44052688039255716 VICAEEPYICK(ub)DFPETNNILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VICAEEPYICKDFPETNNILK 21 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 44051400.0 12607000.0 22088000.0 9356400.0 True False 17268148.591364738 21112079.124751665 7146611.021106707 1.0 1.2226023544474918 0.4138608712621632 24.04161007647973 -6.833335949518039 1.3131112292391909 1.1186929382795279 0.3906042771614426 0.9123504948591658 0.10098638740345597 0.17673276247093214 0.5948160814514939 0.06036445268871967 0.13890653105169937 1.4677904256436674e-07 6.833335949518039 -0.7280886611180852 down VICAEEPYICK(ub)DFPETNNILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VICAEEPYICKDFPETNNILK 21 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 135149000.0 39171000.0 40041000.0 55937000.0 True False 50707631.67584542 37812683.151132226 45757039.962088406 1.0 0.7457000435921423 0.9023698889073688 25.59569955842869 -10.350098836088739 5.4843527260334435 1.0000479885001194 0.8240349664424913 0.6271410508268664 0.06396019651718839 3.754000293934137e-05 4.448536903492718e-06 0.06194606066790591 0.020643064660934008 4.465819481334766e-11 10.350098836088739 -0.17601302205762814 VICILSHPIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VICILSHPIK 10 0 P50395;P50395-2;Q5SX91 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 12784500.0 4024300.0 5389600.0 3370600.0 False True 5275896.271376639 4585492.688496251 3021842.6450782404 1.0 0.8691400385132588 0.5727638470590612 22.330984769576705 -6.9575420225598705 0.46879160278457704 1.007920739258918 0.4218578518745131 0.9996678945786904 0.003257094566368923 0.08059112172497594 0.024466175224014328 0.004088641116549129 0.024463737669299948 1.1027015307138732e-07 6.9575420225598705 -0.5860628873844049 VICILSHPIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VICILSHPIK 10 0 P50395;P50395-2;Q5SX91 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 19602300.0 4458400.0 10974000.0 4169900.0 False True 6763718.752699622 9015603.959746644 3345717.437267904 1.0 1.332935961618484 0.4946564988280328 22.689385240526626 -6.798986498367052 1.4605051554427781 1.1839328681742864 0.48343162653947974 0.8290492545244132 0.1424915312232382 0.22221317884144776 0.9359617846557194 0.0767639024168221 0.1785995158482675 1.5885961351532432e-07 6.798986498367052 -0.7005012416348066 down VICILSHPIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VICILSHPIK 10 0 P50395;P50395-2;Q5SX91 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 17789100.0 4024300.0 6990500.0 6774300.0 False True 5512192.4626183165 6681636.595507818 5174349.861087937 1.0 1.2121558963734025 0.9387099409497209 22.394194831099597 -6.699558251221257 1.832140276216472 1.1317928498571928 0.9395211841034178 0.4156563690262075 0.08956028073366744 0.39642279874558567 2.586668742586926 0.038999759110772164 0.1003631602504829 1.9972928567931704e-07 6.699558251221257 -0.19227166575377497 VICILSHPIK(ub)NTNDANSCQIIIPQNQVNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VICILSHPIKNTNDANSCQIIIPQNQVNR 29 1 P50395;P50395-2;Q5SX91 P50395 GDI2 Rab GDP dissociation inhibitor beta 1 42606000.0 7533500.0 5859500.0 29213000.0 True False 9752264.257485937 5533413.674085542 23896533.750692513 1.0 0.5673978399260496 2.4503574882468233 23.217305788575896 -6.846276376613874 1.2530549983293353 0.7697007345211376 2.520339989485964 0.934690593498225 0.2057938469036206 0.16160223221274017 0.49017926097494297 0.1286320046732826 0.29701662498023174 1.4247006530952755e-07 6.846276376613874 1.7506392549648266 up VIDPATATSVDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIDPATATSVDLR 13 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 24657600.0 3134300.0 9824300.0 11699000.0 False True 4109097.652604376 8358552.734821459 10488499.70473221 1.0 2.034157725485971 2.5525068011183727 21.970390185849215 -9.420294919369343 0.19846590509973552 1.1023474131976208e-19 3.0681486536397538 0.9995027824223278 0.014390554805980709 0.8498907836840498 0.07720083496475368 0.8134531339623033 0.3001292546490472 3.7993130610883636e-10 9.420294919369343 3.0681486536397538 VIDPATATSVDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIDPATATSVDLR 13 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 17732700.0 4146600.0 2927100.0 10659000.0 False True 4014968.4527340867 4095906.2946248464 7867088.136854259 1.0 1.0201590231264814 1.9594395894934074 21.936957221260315 -6.911534519718534 0.8852271926528624 0.972308790713334 2.0848925953154853 0.9914873948745154 0.04129803317772766 0.10341283372871139 0.13333170121969598 0.03406959573769442 0.09507718934749565 1.225929456305875e-07 6.911534519718534 1.1125838046021514 VIDPATATSVDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIDPATATSVDLR 13 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 26235900.0 3134300.0 9996600.0 13105000.0 False True 4293135.411272664 9554917.157664457 10009868.905947076 1.0 2.2256267837664088 2.3315986911718993 22.033600247372107 -10.732320925644569 0.46317896212948706 6.985023285127473e-22 2.3314224468196625 0.9996088509724045 0.011951424945363708 2.2973906574588323 0.22233161699334017 2.6042392248906587 0.023173682824231698 1.8521624462167245e-11 10.732320925644569 2.3314224468196625 VIDPATATSVDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIDPATATSVDLR 13 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 8639800.0 4146600.0 2046900.0 2446300.0 False True 3448081.6255268063 2035872.943422162 2957810.01958677 1.0 0.5904364120472688 0.8578132250958149 21.71736249669459 -10.167128023166079 7.024515521596053 1.0000003892158367 0.724124818571542 0.5866809220476858 0.1091561268367449 6.653037375759929e-07 7.89189634721037e-08 0.10569011338062102 0.03522998844793479 6.805687081957189e-11 10.167128023166079 -0.2758755706442947 VIDTIK(ub)TNPDDRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIDTIKTNPDDRR 13 2 P04818;P04818-3 P04818 TYMS Thymidylate synthase 1 16614300.0 3515900.0 5360600.0 7737800.0 True False 3404289.679006356 7501115.535159695 5711038.050975786 1.0 2.2034304487710696 1.6776004951032026 21.69892237388171 -10.577997082655205 5.692705212415496 0.9962758451448306 1.9405154719371351 0.8100880671916063 0.2146691796595998 0.010162374143029031 0.0007533411179390907 0.20817694074895757 0.0692841798138031 2.6424265075896724e-11 10.577997082655205 0.9442396267923046 VIDTIK(ub)TNPDDRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIDTIKTNPDDRR 13 2 P04818;P04818-3 P04818 TYMS Thymidylate synthase 1 121115000.0 11375000.0 13938000.0 95802000.0 True False 17256706.623891585 11450655.00190895 76866692.70849174 1.0 0.6635481063377258 4.4543083673956225 24.040653822196667 -6.885257651705592 1.0500600243633342 0.7725643969134048 4.751560734305218 0.9776840430191827 0.2559259682076215 0.12307397555629598 0.24501648209059643 0.18677043779009095 0.4583299458957391 1.3023938845322468e-07 6.885257651705592 3.978996337391813 up VIDTIK(ub)TNPDDRR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIDTIKTNPDDRR 13 2 P04818;P04818-3 P04818 TYMS Thymidylate synthase 1 13154900.0 3515900.0 6709600.0 2929400.0 True False 2923626.6307793567 6673454.053048678 3541923.9959847433 1.0 2.2825944950671495 1.2114830117827207 21.479327649315987 -6.601942538675489 2.1839449479534556 1.8615169114501728 1.2150685087208606 0.025976345842011805 0.5541116242787724 0.6352343967363666 5.729208780643892 0.21041777020195432 0.6159540512619468 2.500676203250473e-07 6.601942538675489 -0.6464484027293123 VIDTIK(ub)TNPDDRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIDTIKTNPDDRR 13 2 P04818;P04818-3 P04818 TYMS Thymidylate synthase 1 116003600.0 11375000.0 32940600.0 71688000.0 True False 14725161.734771704 31107426.652885377 58641519.58099625 1.0 2.112535482678531 3.9824024100544397 23.811780144289116 -6.963298288916653 0.38615132679797115 0.8801186967301602 5.281592524984196 0.9998736468177677 0.013832529057790505 0.07854333158516359 0.01692657507894064 0.0242026080240533 0.15755328481368625 1.0881824341542504e-07 6.963298288916653 4.401473828254036 VIECDVVK(ub)DYAFVHMEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIECDVVKDYAFVHMEK 17 1 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 1 7733900.0 1601400.0 3315000.0 2817500.0 True False 2099450.9079796616 2820414.9217687952 2525972.1273684064 1.0 1.3434059882271454 1.2031584628950402 21.00158062296872 -10.13553115287439 4.29898536782622 0.9999509757913446 1.273282225545331 0.8350534658074632 0.05725581256767025 39995200.9457944 2.1820304457570185 20790.110778676317 0.019600187540727395 7.31928818493158e-11 10.13553115287439 0.2733312497539865 VIECDVVK(ub)DYAFVHMEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIECDVVKDYAFVHMEK 17 1 Q96PK6;Q96PK6-2 Q96PK6 RBM14 RNA-binding protein 14 1 7269900.0 1601400.0 2680600.0 2987900.0 True False 2193480.8562077815 2562162.228441206 2282219.5577321094 1.0 1.1680805060094404 1.0404556535212917 21.064790684491612 -9.983291858331338 4.854783396934945 0.9999987920538959 1.1042680797682687 0.4708885529186636 0.05210262785900388 6.815508211949925e-07 1.427698521934933e-07 0.050448737341807146 0.016816050831204413 1.0392215444642605e-10 9.983291858331338 0.10426928771437283 VIEPLKDFHK(ub)DEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIEPLKDFHKDEVR 14 2 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 31158300.0 3402900.0 4508400.0 23247000.0 True False 4405121.131187217 4257503.576797887 19016284.534363102 1.0 0.9664895584041416 4.316858485396076 22.070750259970517 -6.904640082471704 0.9314542062234317 0.8778765622096852 4.703662467665732 0.9887371036607783 0.16678251388117646 0.10807033700696117 0.15877836371534543 0.13302716965373235 0.35491510805242593 1.2455464192172893e-07 6.904640082471704 3.8257859054560472 up VIFFLPWQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIFFLPWQK 9 0 F5GYK7;P43304-2;P43304 F5GYK7 GPD2 Glycerol-3-phosphate dehydrogenase;Glycerol-3-phosphate dehydrogenase, mitochondrial 0 2090680.0 752840.0 937730.0 400110.0 False True 986980.5305129309 797824.3392429108 358710.4553261304 1.0 0.8083486092965622 0.3634422810141043 19.912662100344946 -6.957029447395218 0.4754536866004743 1.0111495191809912 0.1422339512552441 0.9996436643729611 0.005033343214483694 0.08077984402780346 0.025185485669075056 0.0062163667388645625 0.03670823871401853 1.1040037602420881e-07 6.957029447395218 -0.8689155679257471 down VIFFLPWQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIFFLPWQK 9 0 F5GYK7;P43304-2;P43304 F5GYK7 GPD2 Glycerol-3-phosphate dehydrogenase;Glycerol-3-phosphate dehydrogenase, mitochondrial 0 3463640.0 752840.0 1009400.0 1701400.0 False True 1031185.2927360219 964801.3703605734 1299564.3614329158 1.0 0.935623672250684 1.260262700202802 19.975872161867837 -6.855177143372757 1.209805525205033 0.9654273258246338 1.274599469287449 0.94751020951134 0.032154043682947 0.15185363975434102 0.42509964026623953 0.020765764917978612 0.04824154089754292 1.3957989157343136e-07 6.855177143372757 0.3091721434628152 VIFGLFGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIFGLFGK 8 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 1609140000.0 437900000.0 544080000.0 627160000.0 False True 574091140.6296319 462905384.80722964 562267499.3435206 1.0 0.8063273442950891 0.9794045919727246 29.096704551220334 -10.305005877013906 6.732586943231697 1.000002242947415 0.8928659681525217 0.33813137280965866 0.07065849048258527 2.3789367109079877e-06 2.454648643762737e-07 0.06841622151265561 0.022804929742267336 4.9544348625734326e-11 10.305005877013906 -0.10713627479489318 VIFGLFGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIFGLFGK 8 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 2382590000.0 960470000.0 494670000.0 927450000.0 False True 929980405.5846964 692194310.6699716 684523022.0963973 1.0 0.7443106397868413 0.7360617685982583 29.792625078476995 VIFGLFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIFGLFGK 8 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 849380000.0 274720000.0 223200000.0 351460000.0 False True 416770324.72224194 183368216.1304406 281993776.9496098 1.0 0.43997426220940034 0.6766167364184232 28.634677316225382 -10.309493961744225 5.745395134735438 1.0000476323262304 0.558295499313913 0.8228625769682915 0.09660888554698209 5.89503984286149e-05 7.085157474270394e-06 0.09355120024480451 0.031180383734925248 4.903498403714305e-11 10.309493961744225 -0.4417521330123174 VIFGLFGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIFGLFGK 8 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 2025620000.0 437900000.0 575420000.0 1012300000.0 False True 599803463.8025391 549996041.7405204 773215588.9729284 1.0 0.9169604294275703 1.289114911192774 29.159914612743226 -6.84813758698212 1.2440156597514869 0.9557478138088852 1.303468809747736 0.9375585053099953 0.039858047544382054 0.15951423379738003 0.47597661961902343 0.025082651581260898 0.05797893293339556 1.418608027334271e-07 6.84813758698212 0.34772099593885086 VIFGLFGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIFGLFGK 8 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 1799470000.0 960470000.0 347760000.0 491240000.0 False True 798673361.0354812 345886547.85504454 593956012.7628682 1.0 0.43307635477738 0.7436782566439969 29.57303035391127 -10.131501552288976 5.4461463850696505 1.0000076653083463 0.5883773057105849 0.7007500912949165 0.12680269545228484 1.1801994330119546e-05 1.8822690943125504e-06 0.12277846585421599 0.04092539397834922 7.387516224856483e-11 10.131501552288976 -0.4116303595977614 VIFGLFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIFGLFGK 8 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 1389750000.0 274720000.0 631060000.0 483970000.0 False True 355630455.5407901 595940956.2536775 395892425.951551 1.0 1.6757309363379995 1.1132129427709911 28.40580363831783 -10.239024457161609 4.1224597555246785 0.9997138799771572 1.3944719395842704 0.3960219643204238 0.22964700932551488 31872601.793174557 39581526.61496777 67086.01054466369 0.0786142772518891 5.76733983878899e-11 10.239024457161609 0.3947580596071132 VIFGLFGK(ub)TVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIFGLFGKTVPK 12 1 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 1 8148800.0 2958700.0 2755200.0 2434900.0 True False 2460290.142634003 2740357.1907356195 2944026.332294414 1.0 1.113834967367619 1.1966175376138848 21.23039703230991 -6.974593302478972 0.09925758232026347 0.7929132533663197 1.5196380325094976 0.9999997479517742 4.005164986358711e-05 0.07483822744192152 0.0029121922915086 0.0075444381598788884 0.013643896166853511 1.0602461339131074e-07 6.974593302478972 0.7267247791431779 VIGANK(ub)NQEEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIGANKNQEEEK 12 1 A0A3B3ITZ9;Q9Y2W1 A0A3B3ITZ9 THRAP3 Thyroid hormone receptor-associated protein 3 1 3250880.0 922470.0 2090100.0 238310.0 True False 767074.6773500489 2078840.216447633 288139.51917905535 1.0 2.7100884409706167 0.3756342474691874 19.549007510311235 -6.710334654735176 1.7938053693778597 2.0509536400267425 0.3810161583024226 0.4667716232452245 0.7205835811337555 0.3744110246644858 2.348630186722693 0.31963513953679684 0.8117568832743225 1.9483426847865414e-07 6.710334654735176 -1.66993748172432 VIGIECSSISDYAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIGIECSSISDYAVK 15 0 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;Q99873-5;E9PNR9;H0YDE4;E9PMW9 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 0 11319900.0 1526000.0 5355300.0 4438600.0 False True 2000600.777805019 4556310.1147959 3979336.2500576447 1.0 2.2774709304046685 1.989070630285177 20.93200187382749 -10.531102591670377 6.1902832011282625 0.9985818380153341 2.1332707803449185 0.9536780244343717 0.11773892949304761 0.0023063387965211583 0.00017469899653964476 0.11409600838234854 0.03800007609390518 2.943726166851034e-11 10.531102591670377 1.1346889423295843 VIGIECSSISDYAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIGIECSSISDYAVK 15 0 E9PKG1;Q99873-2;Q99873-3;Q99873;E9PIX6;E9PQ98;Q99873-5;E9PNR9;H0YDE4;E9PMW9 E9PKG1 PRMT1 Protein arginine N-methyltransferase 1 0 4382600.0 1526000.0 2856600.0 0.0 False True 2090203.4385993932 2730385.9664870338 0.0 1.0 1.3062776168412655 0.0 20.99521193535038 -6.881232002407247 1.337367565445813 1.159879940934784 1.3835201079264192e-18 0.9314570745740951 0.14603334880250587 0.14791577279849508 0.5317741088950491 0.0886231031233316 0.18034303012188857 1.3145224197695402e-07 6.881232002407247 -1.159879940934784 down VIGMHYFSPVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIGMHYFSPVDK 12 0 H0YFD6;P40939;A0A2R8Y4F5 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 9543200.0 2706300.0 5501100.0 1335800.0 False True 3547985.507846479 4680357.323119853 1197584.2298983922 1.0 1.3191590869717755 0.33753921126506803 21.75856868612191 -6.819148931560672 1.3754417530372316 1.1721807970610374 0.31648072948862066 0.8824247526472735 0.14018550641598365 0.19459998164379336 0.7236111434424269 0.0800936181828271 0.1846560950901271 1.516530218222529e-07 6.819148931560672 -0.8557000675724167 down VIGMHYFSPVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIGMHYFSPVDK 12 0 H0YFD6;P40939;A0A2R8Y4F5 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 8576300.0 3441000.0 1377400.0 3757900.0 False True 3331767.3385081734 1927403.0030461103 2773593.2554165157 1.0 0.578492675874877 0.8324690693013442 21.667856228340973 -10.29346830195554 5.8496242655389725 1.0000216854550492 0.7054808725881094 0.6419613877098085 0.10368542843453739 2.9325661166879022e-05 3.541983021583121e-06 0.10040036771430969 0.033464328130944694 5.087819529841729e-11 10.29346830195554 -0.2945408128669398 VIGMHYFSPVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIGMHYFSPVDK 12 0 H0YFD6;P40939;A0A2R8Y4F5 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 13132700.0 2706300.0 3841800.0 6584600.0 False True 3706892.2450075634 3672056.5728663043 5029453.094093788 1.0 0.9906024589227875 1.3567842714790126 21.821778747644803 -6.901012160722272 0.9548661065677794 0.9851953994534564 1.3960185330089199 0.9870626141512534 0.01938719416507599 0.110663499680941 0.1732559945646371 0.01519860574580487 0.03974796037319679 1.255994793969391e-07 6.901012160722272 0.4108231335554635 VIGMHYFSPVDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIGMHYFSPVDK 12 0 H0YFD6;P40939;A0A2R8Y4F5 H0YFD6 HADHA Trifunctional enzyme subunit alpha, mitochondrial;Long-chain enoyl-CoA hydratase;Long chain 3-hydroxyacyl-CoA dehydrogenase 0 7353100.0 3441000.0 2127700.0 1784400.0 False True 2861343.9621467567 2116237.657784619 2157509.7898665853 1.0 0.7395956885228461 0.7540197258381647 21.44826150377525 -10.442572399072882 9.002533588463466 1.0000024276707251 0.746807707182231 0.997571832901247 0.005888588575565789 2.8692871095934064e-07 1.77615215664001e-08 0.00570165607193479 0.0019005337904861247 3.609338390858441e-11 10.442572399072882 -0.2531947204884941 VIGNQSLVNELAFTAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIGNQSLVNELAFTAR 16 0 Q13011 Q13011 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 13588400.0 3736300.0 6342800.0 3509300.0 False True 4898325.482380664 5396478.964040755 3146191.2995825894 1.0 1.101698730199117 0.6422993553408155 22.223857210154435 -6.848637873046806 1.2416157239309022 1.0542138176923337 0.6244081014099496 0.9383055552022704 0.04893572594258835 0.1589600539121875 0.4722489401696286 0.030850947471555177 0.0713329138954097 1.4169748009447027e-07 6.848637873046806 -0.42980571628238406 VIGNQSLVNELAFTAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIGNQSLVNELAFTAR 16 0 Q13011 Q13011 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 22696400.0 8159600.0 4273800.0 10263000.0 False True 7900577.96433922 5980350.627572566 7574812.4165996285 1.0 0.756951029983633 0.9587668713339711 22.913526766384308 -10.042603082433992 6.111978070469153 1.000000200046322 0.8578589508069098 0.39809968503657844 0.08239097221982078 2.2454719046176976e-07 3.520330059053734e-08 0.07977482756196336 0.026591571940430873 9.06560761340177e-11 10.042603082433992 -0.14214124923941218 VIGNQSLVNELAFTAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIGNQSLVNELAFTAR 16 0 Q13011 Q13011 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 32916200.0 5677800.0 22476000.0 4762400.0 False True 8613637.702780798 18464982.19421046 3821109.5525659313 1.0 2.1436915309601754 0.44361159412733797 23.0381912131508 -6.725414498125754 1.7395829731907384 1.691720661837998 0.44535290413751205 0.5381340998353339 0.4809748795375513 0.3448548773229875 2.0421864388835016 0.2192866905348801 0.5470689457645701 1.8818521600363878e-07 6.725414498125754 -1.2463677577004861 VIGNQSLVNELAFTAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIGNQSLVNELAFTAR 16 0 Q13011 Q13011 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 19207300.0 3736300.0 5678300.0 9792700.0 False True 5117711.079710953 5427413.9303729385 7479865.946987255 1.0 1.0605158919364939 1.461564717211374 22.287067271677326 -6.933768744244886 0.7151758611350773 0.9946710479929171 1.5524014564131987 0.9972285874467979 0.010782345514360789 0.09072740410021116 0.06843483527632482 0.01005359514495552 0.03556595291059559 1.164746075354969e-07 6.933768744244886 0.5577304084202817 VIGNQSLVNELAFTAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIGNQSLVNELAFTAR 16 0 Q13011 Q13011 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 16372000.0 8159600.0 3152600.0 5059800.0 False True 6785068.931570079 3135616.318057896 6117780.786128092 1.0 0.4621347770644252 0.9016534463876735 22.693932041818584 -10.026172288033981 7.162365810897701 1.000000033702444 0.681894111726052 0.41122352256135497 0.17943274537816847 9.657038946765865e-08 1.3012284406593064e-08 0.17373502677540079 0.05791166955116014 9.415160156239674e-11 10.026172288033981 -0.318105921976392 VIGNQSLVNELAFTAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIGNQSLVNELAFTAR 16 0 Q13011 Q13011 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 18718200.0 5677800.0 7922500.0 5117900.0 False True 7350024.026170262 7481605.910562794 4186494.7140885685 1.0 1.0179022386762309 0.5695892556517187 22.80931753524325 -6.8975994155581075 0.9763338629781098 1.019886694509446 0.5247619246065434 0.9853332288188273 0.02509883516923798 0.11319344951423678 0.18755937982955218 0.019364545583801622 0.04980222793852038 1.265903452859794e-07 6.8975994155581075 -0.49512476990290266 VIGSELVQK(ub)YVGEGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIGSELVQKYVGEGAR 16 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 14204400.0 5710800.0 8493600.0 0.0 True False 7486914.103465869 7226387.987793496 0.0 1.0 0.9652024703272916 0.0 22.835939771987245 -7.051924415246295 1.0485679493259212 1.0119454140355986 1.5203991365250805e-19 0.9879439562634733 0.05088357370203061 0.08513990916370073 0.18016960037002203 0.0406333611972964 0.07273689166875168 8.873104263972927e-08 7.051924415246295 -1.0119454140355986 down VIGSELVQK(ub)YVGEGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIGSELVQKYVGEGAR 16 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 132130200.0 8798200.0 14012000.0 109320000.0 True False 8518905.956891194 19607064.67161469 80685812.4702982 1.0 2.3015942153644695 9.4713819918424 23.022236733118643 -6.937670099460329 0.680894327360519 0.915357818802042 11.279146595214394 0.9978425164081522 0.17301018437557503 0.08884587488752999 0.05957184217268681 0.16557557238665255 0.62368856454327 1.1543297815454848e-07 6.937670099460329 10.363788776412353 VIGSELVQK(ub)YVGEGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIGSELVQKYVGEGAR 16 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 425960000.0 16590000.0 134720000.0 274650000.0 True False 25168242.891460374 110678163.42783557 220365307.11662838 1.0 4.397532394499771 8.75568898738651 24.58510116317911 -6.967726674033799 0.3076791256249061 0.30992023811924674 12.981370797638046 0.9999588281633278 0.020368192186779422 0.07704745445091014 0.011656807375881059 0.06969022121515893 0.38780150521497003 1.0771429070216386e-07 6.967726674033799 12.6714505595188 VIGSELVQK(ub)YVGEGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIGSELVQKYVGEGAR 16 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 67180600.0 5710800.0 6631800.0 54838000.0 True False 7822237.088567123 6338785.147570086 41886393.82406152 1.0 0.8103545156966374 5.354784488095115 22.899149833510137 -6.897158900037282 0.9790268698684884 0.7960507138716624 5.805251149179091 0.9850998728977945 0.25621588134186113 0.11352787973334821 0.18943621779834863 0.19727609079506112 0.5063541082886825 1.267188141145804e-07 6.897158900037282 5.009200435307428 up VIGSELVQK(ub)YVGEGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIGSELVQKYVGEGAR 16 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 108591200.0 8798200.0 18877000.0 80916000.0 True False 7316093.126346871 18775305.854208868 97835161.4866873 1.0 2.566302195716295 13.372596520725143 22.80264200855292 -6.932956708100235 0.7221091051486576 0.8523369199759031 15.767910137617235 0.997088128555544 0.2968226193841724 0.0911313579320918 0.07037020283898371 0.27534273209042326 0.9623803436846358 1.1669259342716249e-07 6.932956708100235 14.915573217641333 VIGSELVQK(ub)YVGEGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIGSELVQKYVGEGAR 16 1 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 1 331174000.0 16590000.0 99414000.0 215170000.0 True False 21476082.037790142 93881523.50807065 176011267.83064088 1.0 4.371445561759035 8.195687999371797 24.35622748527156 -6.969485188031093 0.27019670531295187 0.05158478540303989 12.63054761379795 0.9999780852671732 0.013761037384205517 0.07647006614467906 0.00962621570765082 0.07487361148082416 0.35557941621802713 1.0727902356009885e-07 6.969485188031093 12.578962828394909 VIGSGCNLDSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIGSGCNLDSAR 12 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;F5H5G7;F5H155;A0A087WUM2;G3XAP5;F5H245;Q6ZMR3;P07864;P00338;P00338-3;P00338-5;P00338-2;P00338-4 A0A5F9ZHM4;P00338 LDHB;LDHC;LDHAL6A;LDHA L-lactate dehydrogenase B chain;L-lactate dehydrogenase;L-lactate dehydrogenase A-like 6A;L-lactate dehydrogenase C chain;L-lactate dehydrogenase A chain 0 118888700.0 2765700.0 68293000.0 47830000.0 False True 3625859.4830768984 58103950.60402905 42881010.4177572 1.0 16.024876550020668 11.826440218628782 21.78989158514087 -9.668267960837717 8.186024428094987 1.0000338656559817 13.925658384324098 0.9266739932960707 1.7140044550237479 0.0 7.038401995539152e-18 1.6595777020864275 0.5531925591192101 2.146505665825403e-10 9.668267960837717 12.925624518668116 VIGSGCNLDSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIGSGCNLDSAR 12 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;F5H5G7;F5H155;A0A087WUM2;G3XAP5;F5H245;Q6ZMR3;P07864;P00338;P00338-3;P00338-5;P00338-2;P00338-4 A0A5F9ZHM4;P00338 LDHB;LDHC;LDHAL6A;LDHA L-lactate dehydrogenase B chain;L-lactate dehydrogenase;L-lactate dehydrogenase A-like 6A;L-lactate dehydrogenase C chain;L-lactate dehydrogenase A chain 0 26290700.0 20328000.0 5962700.0 0.0 False True 19682698.766984627 8343637.205069713 0.0 1.0 0.42390717369841413 0.0 24.230424711657346 -8.188084122670219 0.5494822369108538 1.0257749278286252 1.1019949331843304e-15 0.9911203870264725 0.0386181407869808 0.12674018263861775 0.1725757642904045 0.05319947060437398 0.07323770782125669 6.485088054811904e-09 8.188084122670219 -1.0257749278286241 VIGSGCNLDSAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIGSGCNLDSAR 12 0 A0A5F9ZHM4;P07195;A0A3B3IS95;A8MW50;F5H5G7;F5H155;A0A087WUM2;G3XAP5;F5H245;Q6ZMR3;P07864;P00338;P00338-3;P00338-5;P00338-2;P00338-4 A0A5F9ZHM4;P00338 LDHB;LDHC;LDHAL6A;LDHA L-lactate dehydrogenase B chain;L-lactate dehydrogenase;L-lactate dehydrogenase A-like 6A;L-lactate dehydrogenase C chain;L-lactate dehydrogenase A chain 0 129937700.0 2765700.0 57106000.0 70066000.0 False True 3788254.0302322074 54582868.09571116 53517853.85456608 1.0 14.408449818864288 14.127313909644442 21.853101646663763 -10.014568164803231 8.048334367510707 0.9999998445049029 14.267881864254365 0.9996633764493439 0.11477325432700555 3.201249848956485e-07 3.785805166795404e-08 0.1111287256486955 0.03704290854987684 9.670119371284392e-11 10.014568164803231 13.267882019749463 VIGTLEEVHMPQNGINHPGITALAQAFAVNPLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIGTLEEVHMPQNGINHPGITALAQAFAVNPLLR 34 0 P46060;H0Y4Q3 P46060 RANGAP1 Ran GTPase-activating protein 1 0 38916900.0 9413900.0 16936000.0 12567000.0 False True 14281574.548277194 13913638.478428045 10083126.94168823 1.0 0.9742370094694123 0.7060234785459683 23.76765170994862 -6.925547178875204 0.7824770758675943 1.0048212265384242 0.6567242134413535 0.9955883942593281 0.008828947135157585 0.095016748973698 0.08949612698435999 0.007839878580897625 0.024889268561618157 1.1870057455993014e-07 6.925547178875204 -0.34809701309707075 VIGTLLGTVDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIGTLLGTVDK 11 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 11108300.0 2053400.0 5041400.0 4013500.0 False True 2692027.285153888 4289242.771223283 3598221.5202105106 1.0 1.5933132605593525 1.3366214897055995 21.360261601841763 -10.120021312703477 4.610340429308938 0.9999592227021242 1.4649673751418286 0.8139471240446078 0.10479397665912854 4.392678343589495e-05 8.384226592019368e-06 0.10147521061912372 0.033822110527464415 7.585403492690132e-11 10.120021312703477 0.4650081524397044 VIGTLLGTVDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIGTLLGTVDK 11 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 12108500.0 5578200.0 2094300.0 4436000.0 False True 5401123.094352301 2930564.911630219 3274078.5228525717 1.0 0.5425843589261226 0.6061847629942225 22.364827997745156 -10.451746782232147 6.052479969691106 1.0002045152769288 0.5743845609602778 0.9835284967859689 0.025964756233613003 7.168863580576234e-05 6.493785518093056e-06 0.02515214174451264 0.008380089040093155 3.533891552112409e-11 10.451746782232147 -0.425819954316651 VIGTLLGTVDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIGTLLGTVDK 11 0 O00303 O00303 EIF3F Eukaryotic translation initiation factor 3 subunit F 0 11796400.0 2053400.0 5200400.0 4542600.0 False True 2812597.4710484943 4970629.132576899 3469731.4377836837 1.0 1.7672735554028363 1.233639535518113 21.423471663364655 -10.207608711267948 4.627373224659529 0.9998921883137093 1.500456545464081 0.5397417702748291 0.2178551763637413 153261715.89178622 34.32771976460205 176059.96810345846 0.07457762147543313 6.199994278653289e-11 10.207608711267948 0.5005643571503717 VIHDNFGIVEGLMTTVHAITATQK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VIHDNFGIVEGLMTTVHAITATQK 24 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 2139179100.0 1371872200.0 587094000.0 180212900.0 False True 1798537739.4292836 499501863.674488 161566197.83220243 1.0 0.27772665133676383 0.08983197532650664 30.74417728641826 -11.610931342409575 0.23932464841749526 2.399780015606223 9.188978198464786e-18 0.9992929114376109 0.010432813829574967 4.319698939282011 0.1398329546759262 3.1835992713831605 0.09117592957161452 2.4494504447217057e-12 11.610931342409575 -2.399780015606223 VIHDNFGIVEGLMTTVHAITATQK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VIHDNFGIVEGLMTTVHAITATQK 24 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 23886249250.0 10914163700.0 2218498900.0 10753586650.0 False True 10567699547.45466 3104357080.0889263 7936899705.680585 1.0 0.2937590216440855 0.7510527404795748 33.298942303580176 -10.169471938835743 5.5080877072497385 1.0000127185489565 0.5224058810628958 0.5925586301872516 0.18668937895466992 2.9158978426924907e-05 4.396991550816535e-06 0.18076602254212987 0.06025373796707175 6.769055285516081e-11 10.169471938835743 -0.4776068374860607 VIHDNFGIVEGLMTTVHAITATQK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VIHDNFGIVEGLMTTVHAITATQK 24 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 55178895740.0 21074413370.0 15954718400.0 18149763970.0 False True 31971425828.28205 13107474246.736168 14562455166.005362 1.0 0.4099746541532484 0.4554834446302159 34.89606403423454 -9.898208049464518 7.013462463320995 1.0000000106274192 0.43272905153051505 0.9951962595084691 0.01857888591331145 3.087263648483027e-09 4.586424080806857e-10 0.017988929469442142 0.0059963096444436035 1.2641306186051497e-10 9.898208049464518 -0.5672709590969041 VIHDNFGIVEGLMTTVHAITATQK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VIHDNFGIVEGLMTTVHAITATQK 24 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 2000044640.0 1371872200.0 179079440.0 449093000.0 False True 1879090425.7922144 171167118.2042838 343026482.7606633 1.0 0.0910904104745894 0.18254921532903087 30.80738734794115 -10.820361685699176 9.610782432267424 1.0162045400258222 0.13681981292123677 0.9916503559214498 0.03733790072969378 0.011702474474197365 0.0002187344706256333 0.032633661991974795 0.012050755642370816 1.5123012610547153e-11 10.820361685699176 -0.8793847271045854 VIHDNFGIVEGLMTTVHAITATQK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VIHDNFGIVEGLMTTVHAITATQK 24 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 23005619200.0 10914163700.0 4363063300.0 7728392200.0 False True 9075610695.982643 4339558612.002655 9344363276.971848 1.0 0.4781560996136137 1.0296126167143957 33.07934757901445 -9.181933338632044 12.087337858824743 0.9999990465351782 0.7538843581640046 0.20984816440994103 0.2251311803722238 0.0 0.0 0.21798232807310594 0.07266077602436863 6.577587912880388e-10 9.181933338632044 -0.24611468837117367 VIHDNFGIVEGLMTTVHAITATQK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VIHDNFGIVEGLMTTVHAITATQK 24 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 32785138370.0 21074413370.0 4798941700.0 6911783300.0 False True 27281243546.258167 4531876375.786214 5653909660.285591 1.0 0.16611692821487223 0.207245305761037 34.667190356327 -10.726968957511772 6.841003929451596 1.0110269250074169 0.18668111698795462 0.9980857853782149 0.0167905898227741 0.0027782136691731677 0.00011088101319454223 0.015994665492925535 0.0054191395630503155 1.8751285336597025e-11 10.726968957511772 -0.8243458080194622 VIHDNFGIVEGLMTTVHAITATQK(ub)TVDGPSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIHDNFGIVEGLMTTVHAITATQKTVDGPSGK 32 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 71285600.0 12149000.0 9511600.0 49625000.0 True False 15727119.992592663 8982271.098631622 40593759.19549911 1.0 0.5711326106027165 2.5811311425498387 23.906751167589555 -6.850912809496746 1.2306582015897338 0.7709473410113468 2.6629171611608973 0.9416246433195229 0.20883691788149297 0.15645701675518706 0.45552330003048164 0.13275351503807808 0.3073876462346748 1.4095717606516104e-07 6.850912809496746 1.8919698201495505 up VIHLSNLPHSGYSDSAVLK(ub)LAEPYGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIHLSNLPHSGYSDSAVLKLAEPYGK 26 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6RBK5 P43243 MATR3 Matrin-3 1 209281000.0 25098000.0 36714000.0 147469000.0 True False 38075500.90957638 30162099.852208745 118321687.51204103 1.0 0.7921655429783897 3.1075543245783517 25.182359680701076 -6.884994672629416 1.0515806421521214 0.8602570014896506 3.288186515608923 0.9774947768775966 0.15690993618286567 0.12329648846275082 0.24634594410826968 0.11437836477532189 0.28045440322970533 1.3031827641376618e-07 6.884994672629416 2.4279295141192727 up VIHLSNLPHSGYSDSAVLK(ub)LAEPYGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIHLSNLPHSGYSDSAVLKLAEPYGK 26 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6RBK5 P43243 MATR3 Matrin-3 1 13744100.0 1218100.0 8211300.0 4314700.0 True False 1668464.4879147587 7848497.614862066 3295656.724035859 1.0 4.704024371936793 1.9752633321880047 20.670089549428766 -6.5677276250473025 2.31452569185042 3.5406572871701285 1.9804561114780805 0.0 1.6141159000250063 0.7372411133324301 7.4102705312859625 0.5900552667371382 1.8117036293157387 2.7056547281235955e-07 6.5677276250473025 -1.560201175692048 VIHLSNLPHSGYSDSAVLK(ub)LAEPYGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIHLSNLPHSGYSDSAVLKLAEPYGK 26 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6RBK5 P43243 MATR3 Matrin-3 1 37597300.0 13415000.0 14075700.0 10106600.0 True False 11155166.88526555 13999871.4102923 12219843.332361367 1.0 1.2550122785508673 1.0954424490504135 23.411208761186153 -10.151349746390775 4.019187132482224 0.9999346973292601 1.1752273637383135 0.6165399083901373 0.0651441102836637 45936769.2953869 55315361.040905684 35953.25101295941 0.02384030485862412 7.057489710036371e-11 10.151349746390775 0.1752926664090534 VIHLSNLPHSGYSDSAVLK(ub)LAEPYGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIHLSNLPHSGYSDSAVLKLAEPYGK 26 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6RBK5 P43243 MATR3 Matrin-3 1 185933000.0 25098000.0 42191000.0 118644000.0 True False 32489855.755542897 39843033.761130266 97052009.39024279 1.0 1.2263222730477308 2.987148053856328 24.953486002793525 -6.930618609406682 0.7417007211635457 0.973828443456302 3.3543930497515038 0.9966583740733403 0.051345420417502674 0.09231789138094973 0.07611690201759165 0.0469514200442477 0.1587858480884984 1.1732252212439331e-07 6.930618609406682 2.3805646062952017 up VIIEK(ub)YYTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIIEKYYTR 9 1 H3BNC9;P08708;H0YN88;A0A075B716;H0YN73;A0A0J9YYC4 H3BNC9 RPS17 40S ribosomal protein S17 1 64687700.0 20898100.0 24347800.0 19441800.0 True False 27397611.477488283 20715203.146981068 17430149.03491431 1.0 0.7560952225343465 0.6361922844710785 24.70754678879203 -13.999999999990788 0.09297256005865569 2.23370680423331 0.350522252253802 0.9998282905607282 0.001983543884593008 12.13755266829656 0.08930790409450301 2.93078602268185 0.25601605575060626 1.0000000000212118e-14 13.999999999990788 -1.8831845519795078 VIIEK(ub)YYTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIIEKYYTR 9 1 H3BNC9;P08708;H0YN88;A0A075B716;H0YN73;A0A0J9YYC4 H3BNC9 RPS17 40S ribosomal protein S17 1 86366000.0 21810800.0 21572200.0 42983000.0 True False 21118428.09262832 30186091.957536843 31724462.837640204 1.0 1.4293721021818722 1.5022170541525328 24.331999118824253 -11.972901562604656 0.2886328825891881 1.8202532555607361e-10 1.5242453679300785 0.9994398629784192 0.005244234435214587 5.127191311296536 0.16024430620600383 3.1018361648346886 0.027653201026116958 1.0643842447278943e-12 11.972901562604656 1.5242453677480532 VIIEK(ub)YYTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIIEKYYTR 9 1 H3BNC9;P08708;H0YN88;A0A075B716;H0YN73;A0A0J9YYC4 H3BNC9 RPS17 40S ribosomal protein S17 1 131099100.0 23522800.0 27050300.0 80526000.0 True False 35685807.34703092 22222962.620041452 64610000.80420045 1.0 0.6227395222961213 1.810523723784437 25.08884707624687 -6.82130775083575 1.3664572553665444 0.7969298493166282 1.837134847397089 0.8873098300581115 0.16635209057007022 0.19179036829432722 0.7033509149662339 0.09566322030568127 0.22038784444840792 1.5090104564607913e-07 6.82130775083575 1.0402049980804606 VIIEK(ub)YYTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIIEKYYTR 9 1 H3BNC9;P08708;H0YN88;A0A075B716;H0YN73;A0A0J9YYC4 H3BNC9 RPS17 40S ribosomal protein S17 1 68496200.0 20898100.0 21242800.0 26355300.0 True False 28624692.319917455 20304222.8554543 20130720.94444158 1.0 0.7093254533019502 0.7032641860200658 24.77075685031492 VIIEK(ub)YYTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIIEKYYTR 9 1 H3BNC9;P08708;H0YN88;A0A075B716;H0YN73;A0A0J9YYC4 H3BNC9 RPS17 40S ribosomal protein S17 1 80819400.0 21810800.0 41715000.0 17293600.0 True False 18136646.58226982 41490273.01522077 20909611.803427923 1.0 2.287648536735627 1.1528929401904386 24.11240439425853 -6.6157034879085375 2.1328330701454394 1.8569484912601175 1.1571299547847473 0.06851981917937988 0.5543408581783563 0.5969743519055876 5.154210247590846 0.21402643485764605 0.6148632928311105 2.422682554967941e-07 6.6157034879085375 -0.6998185364753702 VIIEK(ub)YYTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIIEKYYTR 9 1 H3BNC9;P08708;H0YN88;A0A075B716;H0YN73;A0A0J9YYC4 H3BNC9 RPS17 40S ribosomal protein S17 1 90177900.0 23522800.0 39768400.0 26886700.0 True False 30450728.303708803 37555253.580766805 21993596.480838843 1.0 1.23331216272396 0.7222683234857175 24.85997339833932 -6.782564261343905 1.5257074438034504 1.1316684865148263 0.717878026103304 0.7763989685069899 0.09877921952920327 0.24661940494065826 1.1340242466533226 0.05098284983964687 0.12005158090138082 1.649816864455925e-07 6.782564261343905 -0.41379046041152234 VIIEYPTLHVVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIIEYPTLHVVLK 13 0 Q9NWK9-2;Q9NWK9 Q9NWK9-2 ZNHIT6 Box C/D snoRNA protein 1 0 25232700.0 6643300.0 9123500.0 9465900.0 False True 10078371.790285617 7495340.142769151 7594960.715948647 1.0 0.74370546143116 0.7535900514475273 23.264759247511943 -9.955085721770818 5.114616263725011 1.0000010831476447 0.7486477564376237 0.9988414614072448 0.00403536698651306 5537322.575754771 0.00020294322177493403 74.18223853417199 0.0013814134523691306 1.1089559060882747e-10 9.955085721770818 -0.251353326710021 VIIEYPTLHVVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIIEYPTLHVVLK 13 0 Q9NWK9-2;Q9NWK9 Q9NWK9-2 ZNHIT6 Box C/D snoRNA protein 1 0 17043100.0 6643300.0 6247400.0 4152400.0 False True 8599882.809020553 5899726.6980940355 3396705.807221973 1.0 0.6860240806892995 0.3949711737535673 23.035885569604392 -7.194632134196295 0.22660631319193017 1.1371531665242276 1.4712675736109132e-14 0.9999792787545877 0.0011246218662052272 0.08983714498280544 0.01091244647445927 0.012355447293283962 0.037607727830888275 6.388043514075275e-08 7.194632134196295 -1.137153166524213 down VIIGTK(ub)TILANGALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIIGTKTILANGALR 15 1 P49770;H0YK01 P49770 EIF2B2 Translation initiation factor eIF-2B subunit beta 1 7021000.0 2414000.0 2047500.0 2559500.0 True False 2337368.8913567946 2865077.427571447 1889090.1666458843 1.0 1.2257703258420318 0.8082122482383627 21.156454012359013 -6.759826673335229 1.6128853955865234 1.1311641092761944 0.8066858955358863 0.6903864593067373 0.09495768613413909 0.28319015731332464 1.451869029407492 0.0464511648282847 0.11165914632163931 1.738494522425082e-07 6.759826673335229 -0.32447821374030805 VIIGTK(ub)TILANGALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIIGTKTILANGALR 15 1 P49770;H0YK01 P49770 EIF2B2 Translation initiation factor eIF-2B subunit beta 1 4533700.0 1327600.0 1876300.0 1329800.0 True False 1818449.5970409939 1793398.8619056328 1015728.6280906852 1.0 0.986224124564066 0.5585684803931288 20.794277507706788 -6.913757424755065 0.8697467800010654 1.0117200358846654 0.4986160972505817 0.99226412072605 0.01802376506585563 0.10198575692066535 0.1256743271525995 0.015036100957052096 0.042671391656273504 1.2196706559240952e-07 6.913757424755065 -0.5131039386340837 VIIIGSGVSGLAAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIIIGSGVSGLAAAR 15 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 7082400.0 2214300.0 2874200.0 1993900.0 False True 2902968.743311705 2445380.5635438515 1787590.3548393506 1.0 0.8423723366563578 0.615780090280982 21.469097607664235 -6.9659549349772565 0.3412708560546839 1.0242181711406435 0.42638949943511434 0.9999314924448302 0.0013052352007645724 0.07763843704348258 0.01372586510203958 0.0031863889160352213 0.019594388136488398 1.0815461732492645e-07 6.9659549349772565 -0.5978286717055292 VIIIGSGVSGLAAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIIIGSGVSGLAAAR 15 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 5505400.0 2206300.0 1023900.0 2275200.0 False True 2136262.214167563 1432748.6095679617 1679256.8654630666 1.0 0.670680125345128 0.7860724466904558 21.026657309917734 -10.357916963606446 4.952348442401792 1.0001795348478422 0.7283762860177245 0.8807804712657749 0.04710871792212015 9.344329268460491e-05 1.2115036552233191e-05 0.045642775554430526 0.015204273331096183 4.386145521422291e-11 10.357916963606446 -0.27180324883011764 VIIIGSGVSGLAAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIIIGSGVSGLAAAR 15 0 R4GMQ1;O60341;O60341-2 R4GMQ1 KDM1A Lysine-specific histone demethylase 1A 0 8239600.0 2214300.0 1966600.0 4058700.0 False True 3032986.5492075 1879709.1093234648 3100118.6515503586 1.0 0.619755174916493 1.022133992767096 21.532307669187126 -11.032050675979784 12.821617522631152 1.46124213215693 0.8209445838417945 0.20887579359248754 0.1642704645063788 0.042725422969482604 0.00010680244802752556 0.0031376128999507824 0.053018064442246826 9.288579959591014e-12 11.032050675979784 -0.6402975483151355 VIILMLTNQTVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIILMLTNQTVHR 13 0 Q12769;G3V198;E9PR16;Q12769-2 Q12769 NUP160 Nuclear pore complex protein Nup160 0 3295560.0 1884100.0 785820.0 625640.0 False True 2470073.345650355 668578.7191023692 560904.7743626508 1.0 0.2706716058774913 0.22708021012832236 21.236122450743437 -13.63517540377679 0.40407866021918465 9.99999999995278 0.2247178225611316 0.9998368308167331 0.004528683627924788 20.14146394796077 0.20951908409717404 157.37396353204872 0.011033650301126385 2.3164588846826073e-14 13.63517540377679 -9.775282177391649 VIILMLTNQTVHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIILMLTNQTVHR 13 0 Q12769;G3V198;E9PR16;Q12769-2 Q12769 NUP160 Nuclear pore complex protein Nup160 0 13218000.0 2185500.0 3092600.0 7939900.0 False True 3315563.281451873 2540701.3674059142 6370575.284818198 1.0 0.7662955436921567 1.921415682353843 21.660822560121552 -6.85405975711406 1.2154513722228018 0.8747149264738948 1.9713066869159441 0.9459862503808055 0.11589211333449875 0.1530559116400569 0.4330985424355759 0.074527076683995 0.17295666394799397 1.3993947584275836e-07 6.85405975711406 1.0965917604420494 VIILMLTNQTVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIILMLTNQTVHR 13 0 Q12769;G3V198;E9PR16;Q12769-2 Q12769 NUP160 Nuclear pore complex protein Nup160 0 10453000.0 1884100.0 3990500.0 4578400.0 False True 2580702.6858880227 3814186.5151811624 3497076.2151078293 1.0 1.4779643296526026 1.3550868274097532 21.29933251226633 -10.00418798017147 4.863097675458412 0.9999942090936931 1.416525578472678 0.9387279493766286 0.050164530257714876 34587596.06199188 0.03178745994426965 2317.15652735537 0.017172653000876358 9.904031656594283e-11 10.00418798017147 0.41653136937898494 VIILMLTNQTVHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIILMLTNQTVHR 13 0 Q12769;G3V198;E9PR16;Q12769-2 Q12769 NUP160 Nuclear pore complex protein Nup160 0 12708600.0 2185500.0 4857400.0 5665700.0 False True 2829172.832645587 4587081.420002237 4634600.73499122 1.0 1.6213507238130844 1.6381469104725424 21.431948882214 -11.332942867324773 0.589955430806838 1.7233678429360936e-11 1.6362067161647096 0.999937183018577 0.002353499710395771 3.900398134109567 0.2923429989232745 5.07910188572671 0.002961346865197661 4.645763875490172e-12 11.332942867324773 1.6362067161474758 VIISAPSADAPMFVMGVNHEK ddPTM_RPMI8226_Bortezomib_1h_R1 4 VIISAPSADAPMFVMGVNHEK 21 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 1979754300.0 534517300.0 813109600.0 632127400.0 False True 700757356.5728967 691796817.156397 566720920.4421864 1.0 0.9872130640763846 0.808726323208043 29.384339743894344 -6.92132945525362 0.8148127590563788 1.0037528805713805 0.7790455156651247 0.9945420039436726 0.006450275465103039 0.09739647513484724 0.10160995873320708 0.0055970058482153 0.016984645077312004 1.198589709522352e-07 6.92132945525362 -0.22470736490625576 VIISAPSADAPMFVMGVNHEK ddPTM_RPMI8226_Bortezomib_2h_R1 4 VIISAPSADAPMFVMGVNHEK 21 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 1891427900.0 678145600.0 395167100.0 818115200.0 False True 656618239.1261345 552959383.7992033 603826286.1900896 1.0 0.8421322327797558 0.9196002337578933 29.29047958383672 -10.0923186197112 4.399138497513308 1.0000118109400749 0.8808662332593571 0.7592269616129835 0.03162617899581888 7024507.803678313 16115330.646145111 453.66753567623437 0.010826482754926252 8.085025244741884e-11 10.0923186197112 -0.11914557768071776 VIISAPSADAPMFVMGVNHEK ddPTM_RPMI8226_Bortezomib_8h_R1 4 VIISAPSADAPMFVMGVNHEK 21 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 3031770300.0 522332600.0 1866000000.0 643437700.0 False True 792416741.8280885 1532997720.875456 516261956.566238 1.0 1.9345852251163487 0.6515030908802263 29.56168412026674 -6.711422295464577 1.7903918481515257 1.5737405671597204 0.6544254995127947 0.47171392586415073 0.39374397531632777 0.3722364231296771 2.3268748566083772 0.17496295503786713 0.4436804979875437 1.9434693888014214e-07 6.711422295464577 -0.9193150676469257 VIISAPSADAPMFVMGVNHEK ddPTM_RPMI8226_Carfilzomib_1h_R1 4 VIISAPSADAPMFVMGVNHEK 21 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 2070732400.0 534517300.0 676159100.0 860056000.0 False True 732142790.5968974 646284155.2028657 656928486.2093258 1.0 0.8827296580711622 0.8972682578404532 29.447549805417236 -10.14360541973663 5.058754860524485 1.0000051180722462 0.8899989579556226 0.9870681582815238 0.005935358502194591 3.4262430297873135e-07 5.800964689778874e-08 0.0057471535448235 0.001915628719305316 7.184467429489396e-11 10.14360541973663 -0.11000616011662367 VIISAPSADAPMFVMGVNHEK ddPTM_RPMI8226_Carfilzomib_2h_R1 4 VIISAPSADAPMFVMGVNHEK 21 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 1503132600.0 678145600.0 400936300.0 424050700.0 False True 563908113.3439087 398776376.5722759 512717740.78109133 1.0 0.7071655241978679 0.9092221385869687 29.070884859270997 -10.081295495548563 5.193699022637921 1.000003246294321 0.808193832135735 0.545760801722514 0.08248926740248023 3.1007781370132207e-06 5.483827966408455e-07 0.07987124163282128 0.02662329657404668 8.292863260730436e-11 10.081295495548563 -0.19180941415858588 VIISAPSADAPMFVMGVNHEK ddPTM_RPMI8226_Carfilzomib_8h_R1 4 VIISAPSADAPMFVMGVNHEK 21 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 1742247400.0 522332600.0 719638400.0 500276400.0 False True 676169847.4148402 679589890.427006 409231228.46934414 1.0 1.0050579643934752 0.6052195761670436 29.33281044235919 -6.904035300841022 0.9353964052390246 1.0148338230489624 0.5596324276563066 0.988469392002854 0.020112917341663466 0.10849587235747819 0.16113826091114172 0.015995766881303743 0.042527861830700245 1.247282127051962e-07 6.904035300841022 -0.4552013953926558 VIISAPSADAPMFVMGVNHEK(ub)YDNSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIISAPSADAPMFVMGVNHEKYDNSLK 27 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 17311600.0 2231300.0 6641600.0 8438700.0 True False 3056271.908615226 6348152.151165826 6445652.860481928 1.0 2.0770901087927505 2.1089919526834264 21.543341471258085 -10.929549128096571 0.6142122449457285 5.73451231458512e-19 2.1048693759779367 0.9999206532387525 0.0045912733898566625 2.7385510611625756 0.30426067433552634 3.9268122570392228 0.005447971386088566 1.1761179327901662e-11 10.929549128096571 2.1048693759779367 VIK(ub)AVVPAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIKAVVPAK 9 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 4927100.0 1929100.0 1807900.0 1190100.0 True False 2529068.781430975 1538168.367139006 1066959.8682453022 1.0 0.6081955455037855 0.4218785491636983 21.27017484289314 -13.999999999999998 0.0986830759611984 2.942649252299852 0.016815283014308628 0.9998002968907395 0.0034048074323401274 12.090609814266877 0.09328381811682501 4.7996713540474785 0.3615463305658683 1.0000000000000041e-14 13.999999999999998 -2.9258339692855433 VIK(ub)AVVPAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIKAVVPAK 9 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 6869400.0 2119100.0 2342800.0 2407500.0 True False 2051830.3304366942 3278292.2575406036 1776903.526548143 1.0 1.5977404217642497 0.866008997035326 20.96848000613756 -6.689535574992989 1.8677950594563852 1.3749123073091416 0.8685369907278637 0.36827942959195104 0.2528271423489092 0.41772148572190815 2.8249937807360155 0.10829466505268173 0.282200208274334 2.0439225023602203e-07 6.689535574992989 -0.5063753165812779 VIK(ub)AVVPAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIKAVVPAK 9 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 6158900.0 1779500.0 1574000.0 2805400.0 True False 2699631.59887605 1293107.4022818676 2250911.460349497 1.0 0.4789940237846648 0.8337846768746628 21.36433111484567 -10.09235223024928 5.638075518720897 1.00000262228533 0.656389350329605 0.5556792745102499 0.14484267759677313 4.7741986357872945e-06 7.687529306146932e-07 0.140244389348689 0.04674777317933346 8.084399559762588e-11 10.09235223024928 -0.343613271955725 VIK(ub)AVVPAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIKAVVPAK 9 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 5660200.0 1929100.0 2105700.0 1625400.0 True False 2642340.4019672973 2012663.2113812752 1241513.9961637838 1.0 0.7616971719021479 0.46985392012302485 21.333384904416032 -6.968407780296446 0.2937363152859765 1.0545349399081896 0.1679520818511331 0.9999671628465243 0.0012423243349604651 0.07682279523414046 0.010869624239343813 0.004998696441630566 0.02635333317774405 1.0754549422458005e-07 6.968407780296446 -0.8865828580570565 down VIK(ub)AVVPAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIKAVVPAK 9 1 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 1 7179580.0 2119100.0 4281900.0 778580.0 True False 1762125.5420474242 4258832.554809395 941377.4782528167 1.0 2.416872381215831 0.534228382592437 20.748885281571837 -6.705339300223195 1.8117123453605257 1.875171851840825 0.5392088125327048 0.44300158718972005 0.5975155051292247 0.3845166160854076 2.4571931703229217 0.26274660486357687 0.6713261975117368 1.9708823478727506e-07 6.705339300223195 -1.33596303930812 VIK(ub)DYPSNEDLHER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIKDYPSNEDLHER 14 1 P49815;P49815-5;X5D2U8;A0A2R8YDZ2;A0A2R8Y7X5;A0A2R8YGU4;A0A2R8Y7C8;A0A2R8YGD6;P49815-3;P49815-2;P49815-4;A0A2R8Y5F1;P49815-6;P49815-7;A0A2R8YDR3;H3BMQ0;A0A2R8YEJ8;A0A2R8YGE6;A0A2R8Y5B2;C9JX95;A0A2R8YCR8 P49815 TSC2 Tuberin 1 34344400.0 1085300.0 15112200.0 18146900.0 True False 1646479.4460579816 12415309.837842487 14560157.26093117 1.0 7.540519177185814 8.84320620934033 20.65095307138479 -9.341986444876303 0.5267022792682399 7.865899499963768e-18 8.805277181963072 0.9980271793658384 0.15242548662335412 0.7002508029594642 0.2236723539910186 1.8054373143621187 0.25063666013682645 4.5500226137972585e-10 9.341986444876303 8.805277181963072 VIK(ub)DYPSNEDLHER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIKDYPSNEDLHER 14 1 P49815;P49815-5;X5D2U8;A0A2R8YDZ2;A0A2R8Y7X5;A0A2R8YGU4;A0A2R8Y7C8;A0A2R8YGD6;P49815-3;P49815-2;P49815-4;A0A2R8Y5F1;P49815-6;P49815-7;A0A2R8YDR3;H3BMQ0;A0A2R8YEJ8;A0A2R8YGE6;A0A2R8Y5B2;C9JX95;A0A2R8YCR8 P49815 TSC2 Tuberin 1 24596900.0 1085300.0 8680000.0 14831600.0 True False 1404942.2444613392 8196950.3696667785 12132400.985067291 1.0 5.834368211206806 8.635515824865033 20.42207939347724 -8.4203609361403 0.3487182814794902 6.804601958639857e-18 9.697394614494277 0.9979455425249697 0.14294997215663566 0.15166168109960393 0.09864801124426462 0.8550059558565847 0.7756801110271213 3.7987355743179634e-09 8.4203609361403 9.697394614494277 VIK(ub)VHEK(ub)DNGDIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIKVHEKDNGDIK 13 2 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 2 19043150.0 914450.0 1912700.0 16216000.0 True False 885421.2852946232 2676451.0845987345 11968543.130427703 1.0 3.0227995746772085 13.517342906936307 19.756004530298483 -6.938984775618919 0.6689421192331553 0.8798813938716663 16.26481666884794 0.9980278680384678 0.24364644314205616 0.08823290542151925 0.056741927240044676 0.23538515495767062 0.9073597389212814 1.1508407314573913e-07 6.938984775618919 15.384935274976272 VIK(ub)VHEK(ub)DNGDIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIKVHEKDNGDIK 13 2 B4DI03;K7EJQ7;Q9BY50 B4DI03 SEC11L3;SEC11C Signal peptidase complex catalytic subunit SEC11;Signal peptidase complex catalytic subunit SEC11C 2 14696950.0 914450.0 2108900.0 11673600.0 True False 760405.6920038073 2097538.937116127 14114495.787371995 1.0 2.758447180463274 18.56179659857323 19.53640980573276 -6.927997956716175 0.7630437292454637 0.740986137585307 21.64673547015837 0.9961299803409971 0.4912644320950984 0.09369078012986665 0.08287042246366627 0.44234719253174865 1.4459920772810992 1.1803261888784845e-07 6.927997956716175 20.905749332573063 VIK(ub)VYGPSTEPLLLLEEIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIKVYGPSTEPLLLLEEIEK 20 1 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 24850200.0 7132800.0 10099000.0 7618400.0 True False 10820979.07752913 8296754.546152858 6112619.9007366635 1.0 0.766728637649981 0.564886028975894 23.367327703708273 -6.972815904926699 0.17854284331944534 1.159080918115664 0.16708345721909526 0.999996833472663 0.00031631807569490613 0.07539912741094486 0.00562145381161626 0.007873838918136538 0.02275243869023262 1.0645941982926517e-07 6.972815904926699 -0.9919974608965688 VIKDFMIQGGDFTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIKDFMIQGGDFTR 14 1 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 41008500.0 14039000.0 9939500.0 17030000.0 False True 18405264.953869395 8456565.343867542 15267898.963295106 1.0 0.45946447199010265 0.8295397540628878 24.13361518246826 -10.102329076594904 5.793485651012708 1.0000022397183577 0.6445021130264762 0.551642127893697 0.15108260124924236 4.370661106601084e-06 6.772644022613541e-07 0.14628602156826537 0.048761699878320276 7.900797364910223e-11 10.102329076594904 -0.35550012669188147 VIKDFMIQGGDFTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIKDFMIQGGDFTR 14 1 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 10753900.0 4271000.0 1546400.0 4936500.0 False True 4135419.442827203 2163885.584369469 3643482.558174416 1.0 0.5232566162357926 0.8810430498154085 21.979602234246133 -10.330224676537725 5.985223656615647 1.0000291904853362 0.7021498330256021 0.48025794185354687 0.14606569986004203 5.6900526886962615e-05 6.367326125025893e-06 0.14144134419845827 0.047142501917505956 4.674932272451217e-11 10.330224676537725 -0.29787935745973415 VIKDFMIQGGDFTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIKDFMIQGGDFTR 14 1 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 96772000.0 11405000.0 69594000.0 15773000.0 False True 17302218.817185365 57174406.95959616 12655459.636448503 1.0 3.304455201017796 0.7314356482348099 24.044453723535383 -6.670588679922104 1.9351463463527203 2.470162417453707 0.7417760120124542 0.2817252608912514 0.978746483965167 0.45976227333428377 3.3198259411519166 0.4070813732011016 1.0868405536002308 2.135066075844223e-07 6.670588679922104 -1.7283864054412525 VIKDFMIQGGDFTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIKDFMIQGGDFTR 14 1 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 46141000.0 14039000.0 21177000.0 10925000.0 False True 19229597.689709645 20241330.117025804 8344740.007437761 1.0 1.052613291429262 0.43395291685708487 24.196825243991153 -6.886228270285574 1.0444742492413095 1.036308964257805 0.38452113546391586 0.9783708665240476 0.04118845159108978 0.12225516589195 0.2401706911479621 0.030186833296790092 0.07430114531263803 1.299486373183304e-07 6.886228270285574 -0.6517878287938891 down VIKDFMIQGGDFTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIKDFMIQGGDFTR 14 1 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 10477400.0 4271000.0 2994700.0 3211700.0 False True 3551525.7373812245 2978566.9566985923 3883251.6207770165 1.0 0.8386724965408493 1.0934037672609958 21.76000750968041 -6.735571859638017 1.703038964826199 0.9035215447648068 1.093409967839908 0.5848629653327964 0.067793621028319 0.3258791852648582 1.8540509248503674 0.031515486888235404 0.07771138905594024 1.8383497499591285e-07 6.735571859638017 0.18988842307510123 VIKDFMIQGGDFTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIKDFMIQGGDFTR 14 1 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 56851000.0 11405000.0 24072000.0 21374000.0 False True 14763997.326160112 22732372.039011374 17484151.315760158 1.0 1.5397166185293338 1.184242378910503 23.815580045627833 -10.235110234806331 5.113156540383677 0.9999555779653635 1.361979498718889 0.5802869979877185 0.14512175062888044 7.351227677479819e-05 1.0996832048750975e-05 0.14053073841685915 0.0468378436130975 5.8195548415897473e-11 10.235110234806331 0.3620239207535254 VILAGNLLSHSTQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VILAGNLLSHSTQSR 15 0 A0A087WWF6;P49005;F8W8R3;C9JHC7 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 0 24321600.0 8988200.0 6495000.0 8838400.0 False True 11783617.241852617 5525971.31731171 7923887.151919405 1.0 0.4689537349944437 0.6724494685533093 23.490279138509088 -10.152737650796318 5.301573882332486 1.0000138336035738 0.570701601773684 0.8557828454157035 0.08307678534277399 1.358425227570514e-05 2.1710523147925373e-06 0.08044134066146152 0.02681291717398659 7.034971610773187e-11 10.152737650796318 -0.42931223182988976 VILAGNLLSHSTQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VILAGNLLSHSTQSR 15 0 A0A087WWF6;P49005;F8W8R3;C9JHC7 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 0 22101200.0 8306700.0 3137500.0 10657000.0 False True 8043008.355357698 4390320.111846349 7865611.996852974 1.0 0.5458554707234414 0.9779440290663686 22.939303788088527 -10.65572142884259 9.670500398872386 1.0001115356729395 0.7618997498949049 0.2881890952333602 0.17639941527249514 0.00042438765716897015 1.5108514414015404e-05 0.1708769540981004 0.05693266646925834 2.2094214761977352e-11 10.65572142884259 -0.2382117857780346 VILAGNLLSHSTQSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VILAGNLLSHSTQSR 15 0 A0A087WWF6;P49005;F8W8R3;C9JHC7 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 0 15762900.0 3829500.0 8013400.0 3920000.0 False True 5809631.473951019 6583346.161020037 3145210.2818029653 1.0 1.1331779288476673 0.5413786220185095 22.47001522046416 -6.8476147614232685 1.246673549876318 1.0709458075381646 0.5188040311445951 0.9367419874800378 0.06375463153661172 0.16010338237361219 0.4800595283288668 0.040041826664543936 0.09252199756879978 1.4203168474630035e-07 6.8476147614232685 -0.5521417763935695 VILAGNLLSHSTQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VILAGNLLSHSTQSR 15 0 A0A087WWF6;P49005;F8W8R3;C9JHC7 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 0 28182400.0 8988200.0 6873200.0 12321000.0 False True 12311380.43697188 6569519.297367041 9411033.558960248 1.0 0.5336135400087504 0.7644174109589124 23.55348920003198 -10.11088850894515 5.2505285124295655 1.0000075332552363 0.6490154754834933 0.7551054542285687 0.09422528574902857 8.309270410467682e-06 1.4070465351994527e-06 0.09123519752796924 0.030411080207964753 7.74660641330446e-11 10.11088850894515 -0.350992057771743 VILAGNLLSHSTQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VILAGNLLSHSTQSR 15 0 A0A087WWF6;P49005;F8W8R3;C9JHC7 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 0 17153400.0 8306700.0 3722100.0 5124600.0 False True 6907389.099205015 3702048.3085209937 6196130.166526741 1.0 0.5359547949813729 0.8970292649707349 22.719709063522803 -9.830028014495307 6.325744152905692 1.0000000112621634 0.7164920299759685 0.45115480218209336 0.14740803510360947 2.3366622646561648e-08 4.370777258805393e-09 0.14272722264362392 0.047575738754407966 1.4790129802357833e-10 9.830028014495307 -0.2835079812861949 VILAGNLLSHSTQSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VILAGNLLSHSTQSR 15 0 A0A087WWF6;P49005;F8W8R3;C9JHC7 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 0 14763400.0 3829500.0 7152800.0 3781100.0 False True 4957363.240730396 6754740.392183477 3092978.5973622487 1.0 1.3625671681037164 0.6239160713400826 22.24114154255661 -6.77324007161752 1.5621096727141388 1.207096569195026 0.6192484869379514 0.7427832816961162 0.1529457998028203 0.2612198190270394 1.2584118336350543 0.07715564774593923 0.1831176644080443 1.6856209812557233e-07 6.77324007161752 -0.5878480822570745 VILALVLPFHPYVENGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VILALVLPFHPYVENGGK 18 0 Q9H1A3-2 Q9H1A3-2 METTL9 Methyltransferase-like protein 9 0 2023000.0 368090.0 563410.0 1091500.0 False True 504182.8202582254 538516.6832522787 833710.1801481292 1.0 1.0680980422467958 1.6535870455108548 18.94358743446086 -6.928779456727604 0.7567358901808388 0.9906822196623618 1.7701355511539725 0.9962931191175547 0.017861782458351686 0.09327602621509422 0.0808188207093634 0.01615649470129154 0.053336377355112104 1.1782041368424335e-07 6.928779456727604 0.7794533314916107 VILDLTPNYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VILDLTPNYR 10 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 8975600.0 3457800.0 2137200.0 3380600.0 False True 4533209.285382828 1818338.0907403529 3030807.941005017 1.0 0.4011149665212942 0.6685788698919659 22.112101337213435 -10.407823959162853 6.026909421555885 1.000125488677652 0.5348469182066489 0.8013010661945172 0.10919168131186918 0.00018416461808012802 1.809524156745613e-05 0.10575258972931595 0.03524146360543798 3.909993548749987e-11 10.407823959162853 -0.4652785704710032 VILDLTPNYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VILDLTPNYR 10 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 8133400.0 3457800.0 1641400.0 3034200.0 False True 4736242.1035314435 1568877.5206160557 2317584.451310541 1.0 0.3312494349573615 0.4893298105648992 22.175311398736326 -10.323738142026743 8.643982213301284 1.0000008414790351 0.410289622763908 0.9488621161624983 0.06453604309766263 1.0465532784345548e-06 8.197475147981795e-08 0.06248684347616067 0.020828918345614286 4.7452801581369867e-11 10.323738142026743 -0.5897112187151271 VILEK(ub)ATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VILEKATK 8 1 Q9HCS7 Q9HCS7 XAB2 Pre-mRNA-splicing factor SYF1 1 2350780.0 541630.0 1158400.0 650750.0 True False 710082.1751523815 985571.2354078345 583416.6324347794 1.0 1.387967857658635 0.8216184729740328 19.437626466412826 -6.722355987902561 1.751069517536831 1.235448025244941 0.8223985883982752 0.5234487809629986 0.16321371945188026 0.3507902229865145 2.1033733236288445 0.07397596154396467 0.1851784672269316 1.8951518427311486e-07 6.722355987902561 -0.41304943684666573 VILGNELPK(ub)FYDE ddPTM_RPMI8226_Bortezomib_8h_R1 1 VILGNELPKFYDE 13 1 A2ACR1;P28065-2;P28065;A0A0G2JJA7 A2ACR1 PSMB9 Proteasome subunit beta type;Proteasome subunit beta type-9 1 18510100.0 3853000.0 5950900.0 8706200.0 True False 5845282.69203114 4888915.400406084 6985415.753936985 1.0 0.8363864774360923 1.195051825886913 22.478841367995432 -6.782718249010024 1.525665561357498 0.9076833259744974 1.1981189495830693 0.7767543778627851 0.06927247166778554 0.24638069104485066 1.1329598827457865 0.03575839841867188 0.08417148569054124 1.6492319930727635e-07 6.782718249010024 0.2904356236085719 VILHLK(ub)EDQTEYLEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VILHLKEDQTEYLEER 16 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 4 1 75461300.0 14989300.0 31268000.0 29204000.0 True False 19651117.45658767 26602936.281709403 26182250.224549077 1.0 1.3537620107599158 1.3323542685238985 24.228108017572737 -10.233713096072206 5.072748898327442 0.9999555194655463 1.343058139642076 0.997087934150254 0.008739674171198723 4.3972828073419855e-06 6.64240417108413e-07 0.008463247976494044 0.0028207177096005913 5.838306675326915e-11 10.233713096072206 0.3431026201765297 VILHLK(ub)EDQTEYLEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VILHLKEDQTEYLEER 16 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 4 1 39289000.0 12218000.0 10415000.0 16656000.0 True False 11830146.277795076 14573763.813507486 12293293.93071065 1.0 1.2319174650327123 1.039149782432098 23.495964576684237 -10.313746206317603 3.9430821269139935 0.9997332576446849 1.135533623745074 0.39727078207688626 0.0786970769201195 55939274.401330665 57.06999582222946 135475.38429179942 0.02694010264321696 4.855721766875285e-11 10.313746206317603 0.13580036610038904 VILHLK(ub)EDQTEYLEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VILHLKEDQTEYLEER 16 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 4 1 293669000.0 14015000.0 74044000.0 205610000.0 True False 21261779.63374423 60830269.69158742 164971093.3779354 1.0 2.861014963914153 7.759044455343354 24.34175902125574 -6.954350729784093 0.5088466880432913 0.9089939669446566 9.925526325713339 0.9994999476605758 0.0637470727104465 0.08178437952466502 0.02908590895785225 0.07357116197766714 0.4042157246019588 1.1108342716575196e-07 6.954350729784093 9.016532358768682 VILHLK(ub)EDQTEYLEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VILHLKEDQTEYLEER 16 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 4 1 88770300.0 14989300.0 28278000.0 45503000.0 True False 20531249.280601505 27028584.457158983 34756128.563701674 1.0 1.31646078072299 1.6928404155386798 24.29131807909563 -6.968826804585933 0.284821658429416 0.921750888024666 2.099095533535348 0.9999717279682773 0.0015058218741144198 0.07668528724703172 0.010386526809626232 0.006764693172315248 0.03434160791732691 1.0744178017032958e-07 6.968826804585933 1.177344645510682 VILHLK(ub)EDQTEYLEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VILHLKEDQTEYLEER 16 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 4 1 41798100.0 12218000.0 19732000.0 9848100.0 True False 10159808.349174388 19625699.79950467 11907292.17753034 1.0 1.931699804268405 1.1719996842753395 23.276369852118513 -10.261929339886024 4.783660723080981 0.9998373922584411 1.5518497442728632 0.41299111726905 0.31014627525576915 0.0005380179570312526 8.301016619923308e-05 0.30038533824978525 0.10009927991233716 5.471049701377692e-11 10.261929339886024 0.552012352014422 VILHLK(ub)EDQTEYLEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VILHLKEDQTEYLEER 16 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 4 1 274153000.0 14015000.0 85401000.0 174737000.0 True False 18142693.776951686 80648359.2764876 142936658.95302644 1.0 4.445225183646243 7.878469466017879 24.11288534334819 -7.266676653534392 0.2701113034175298 1.292413655368627e-16 11.413201107201761 0.9999231404392845 0.02461871298634246 0.10819028152611794 0.017916109263738288 0.14861850148128158 0.5049989370150755 5.4115708216468236e-08 7.266676653534392 11.413201107201761 VILHLKEDQTEYLEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VILHLKEDQTEYLEER 16 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF6 P08238;Q58FF7;P07900;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 4 0 7397900.0 2352100.0 2562200.0 2483600.0 False True 3083625.877768804 2179929.747377375 2226620.896373443 1.0 0.7069371687056571 0.7220788074280082 21.556196309600253 -10.33578072747265 8.596102654107648 1.0000005570535042 0.7145079880696401 0.9978947473824037 0.00618154812322126 6.599473548504207e-08 5.094301011955037e-09 0.005985269916575525 0.001995086077917966 4.615505496845712e-11 10.33578072747265 -0.2854925689838641 VILK(ub)NSQGEEVAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VILKNSQGEEVAQR 14 1 P20700 P20700 LMNB1 Lamin-B1 1 47740700.0 14616500.0 13172000.0 19952200.0 True False 22174299.109284528 10821353.686694268 16008638.924640067 1.0 0.48801333622144993 0.7219456563538976 24.402385168397856 -10.35952847677493 5.900035464281383 1.0000657377654583 0.6049794962876743 0.791747909480455 0.09550246977831885 8.25957543295236e-05 8.966099934638867e-06 0.09248518290479239 0.030823289581091894 4.3699002460898705e-11 10.35952847677493 -0.39508624147778393 VILK(ub)NSQGEEVAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VILKNSQGEEVAQR 14 1 P20700 P20700 LMNB1 Lamin-B1 1 5807380.0 642480.0 4445230.0 719670.0 True False 880022.2183691611 4248825.040190147 549698.7680688997 1.0 4.8280883726594785 0.6246419199365103 19.74718042310306 -6.667028758198699 1.9479859269459894 3.44965715503981 0.6418550714807545 0.26595130670689593 1.6272076351657703 0.46795465772712114 3.4205327353739645 0.6731885690623312 1.8055359540583698 2.1526391861134223e-07 6.667028758198699 -2.8078020835590554 VILK(ub)NSQGEEVAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VILKNSQGEEVAQR 14 1 P20700 P20700 LMNB1 Lamin-B1 1 21068450.0 6491070.0 9259590.0 5317790.0 True False 5397612.3081580745 9209706.75078528 6429715.302317103 1.0 1.7062556969616953 1.1912147325955746 22.363889926050334 -10.314284641168259 4.890681508847262 0.9998012233042535 1.4487352147787929 0.5030137572881188 0.21026459322220856 0.00045593391957552884 6.392557049159835e-05 0.2036769646780458 0.06786260565376537 4.8497054118651245e-11 10.314284641168259 0.4489339914745394 VILK(ub)NSQGEEVAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VILKNSQGEEVAQR 14 1 P20700 P20700 LMNB1 Lamin-B1 1 47344880.0 14616500.0 12274280.0 20454100.0 True False 18921347.384289294 11591205.52804072 16731663.676789107 1.0 0.612599372160203 0.8842744301963232 24.173511490490306 -10.130668878074506 5.598785698672933 1.0000034154527608 0.7484369011782289 0.5334142084052308 0.11091087800503774 4.728444742638017e-06 7.342804141494684e-07 0.10739045346042646 0.03579633195221189 7.401693920730281e-11 10.130668878074506 -0.2515665142745319 VILWK(ub)DVTEAEQAEEQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VILWKDVTEAEQAEEQAR 18 1 Q12788;J3KNP2 Q12788 TBL3 Transducin beta-like protein 3 1 6941800.0 2358200.0 1940600.0 2643000.0 True False 3091623.0368412877 1651070.0443995534 2369527.713446212 1.0 0.5340463648784466 0.7664348742423523 21.559932990775213 -10.545211978635065 7.137908690615422 1.0001983964975198 0.6502406195603995 0.7512615234353313 0.09487221167125995 0.0002997005468707997 1.909525450497991e-05 0.09191075041526967 0.0306198746517212 2.849627028338823e-11 10.545211978635065 -0.3499577769371204 VILWK(ub)DVTEAEQAEEQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VILWKDVTEAEQAEEQAR 18 1 Q12788;J3KNP2 Q12788 TBL3 Transducin beta-like protein 3 1 11682200.0 2577000.0 2570300.0 6534900.0 True False 2495194.545578481 3596634.1939374274 4823213.647202262 1.0 1.4414243571951983 1.9330010382353 21.25072087346361 -6.96973489332088 0.2644405622924189 0.8692610331470605 2.5198339441176483 0.9999802406897613 0.001693943479322286 0.07638881672403654 0.00933746180620186 0.009974894042237458 0.04607899645349571 1.0721735931820617e-07 6.96973489332088 1.6505729109705878 VILWK(ub)DVTEAEQAEEQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VILWKDVTEAEQAEEQAR 18 1 Q12788;J3KNP2 Q12788 TBL3 Transducin beta-like protein 3 1 8695400.0 2358200.0 2305000.0 4032200.0 True False 3230090.2679587803 2203157.478384309 3079877.405765724 1.0 0.682073036855583 0.9534957695507433 21.623143052298104 -10.109576833166372 6.947814265892265 1.0000001186015897 0.817784404021338 0.37535956533167036 0.11080786661582946 2.0360628266502708e-07 2.6002024064363272e-08 0.10728932585193512 0.03576308516932335 7.770038430733423e-11 10.109576833166372 -0.18221571458025165 VILWK(ub)DVTEAEQAEEQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VILWKDVTEAEQAEEQAR 18 1 Q12788;J3KNP2 Q12788 TBL3 Transducin beta-like protein 3 1 10646200.0 2577000.0 2687400.0 5381800.0 True False 2142889.6804568972 2672922.4427928627 6507109.497368295 1.0 1.247344866686256 3.036604990314237 21.031126148897886 -6.932019538781976 0.7300306116574714 0.9747259595950398 3.4235566907303716 0.9969203922107615 0.050355511711451494 0.09160273245407277 0.07264336979788977 0.04644016087018933 0.16013725256349767 1.1694467767671896e-07 6.932019538781976 2.448830731135332 up VIMAELATKNSK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIMAELATKNSK 12 1 Q9HAN9;B1AN62 Q9HAN9 NMNAT1 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 1 8528600.0 2937200.0 3537000.0 2054400.0 True False 2843960.1937419917 4949342.545211329 1516291.0093210817 1.0 1.7402995147759586 0.5331618257729531 21.4394698413515 -6.74078953290792 1.6841611955947982 1.4400758038897719 0.532380006132166 0.6083571087379903 0.3110351621545335 0.31637668104190353 1.7623582134327378 0.14609565510495368 0.35814609489071264 1.8163957082743433e-07 6.74078953290792 -0.9076957977576059 VIMAELATKNSK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIMAELATKNSK 12 1 Q9HAN9;B1AN62 Q9HAN9 NMNAT1 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 1 6691000.0 3699400.0 1477900.0 1513700.0 True False 5067168.152525956 1412601.4912382532 1156195.235630073 1.0 0.2787753334244649 0.22817384401457366 22.27274827440134 -13.809028768187298 0.3788485449298681 9.999999999890699 0.22358761790466306 0.9998014242328664 0.0049676174539057495 20.562538045378556 0.20027238411013887 149.9634590733179 0.013768508979590437 1.552284181386662e-14 13.809028768187298 -9.776412381986036 VIMAELATKNSK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIMAELATKNSK 12 1 Q9HAN9;B1AN62 Q9HAN9 NMNAT1 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 1 14617200.0 4172300.0 8875100.0 1569800.0 True False 5401124.598328609 8381192.883160095 1284112.507508201 1.0 1.5517495904007983 0.237749099123833 22.364828399472504 -6.792627839511903 1.4857065412620996 1.307320444150858 0.222722246669255 0.8097643000443611 0.23497172743893985 0.23145285932465265 1.009185380105255 0.12446550967341226 0.2908703995626021 1.6120264392049868e-07 6.792627839511903 -1.0845981974816028 down VIMVTGDHPITAK(ub)AIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIMVTGDHPITAKAIAK 17 1 P05023-4;P05023;P05023-3;P05023-2;M0R116;A0A2R8YEY8;A0A0A0MT26;P13637-3;P13637-2;P13637;H0Y7C1;P50993;B1AKY9;Q13733;P54707;P54707-2 P05023-4 ATP1A1;ATP1A3;ATP1A2;ATP1A4;ATP12A Sodium/potassium-transporting ATPase subunit alpha-1;Sodium/potassium-transporting ATPase subunit alpha-3;Sodium/potassium-transporting ATPase subunit alpha-2;Sodium/potassium-transporting ATPase subunit alpha-4;Potassium-transporting ATPase alpha chain 2 1 4498310.0 600490.0 459520.0 3438300.0 True False 822507.3806320771 439216.88697056717 2626244.3540112823 1.0 0.5339975024090843 3.1929736022466773 19.64966909912484 -6.861658009459268 1.1772386854676022 0.7459435244957467 3.3259278040876543 0.955629692454186 0.2442046055681964 0.14510864897296064 0.3811855589345664 0.16167222367837664 0.3781467921468184 1.3751244074267926e-07 6.861658009459268 2.5799842795919075 up VINAAHSFYNGTTTLPISDEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VINAAHSFYNGTTTLPISDEDR 22 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 16504800.0 3717100.0 9163500.0 3624200.0 False True 4873154.096447603 7796341.51904323 3249202.5497812172 1.0 1.599855322598264 0.666755552045809 22.216424412758524 -6.7331376999859485 1.712078629333277 1.3597322716445375 0.667016340063877 0.5736072039926758 0.2521086025234172 0.330395616273352 1.8987364059008398 0.1166325553338545 0.28836146608795293 1.8486823718388373e-07 6.7331376999859485 -0.6927159315806605 VINAAHSFYNGTTTLPISDEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VINAAHSFYNGTTTLPISDEDR 22 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 17776500.0 4807100.0 2953400.0 10016000.0 False True 4654501.241773507 4132708.0217775316 7392509.126440795 1.0 0.8878949230235555 1.588249469157736 22.15019515180835 -6.86591547991671 1.1555690254343178 0.9379288295907516 1.6261891961453125 0.9604292070173799 0.06110066235432561 0.140826685538037 0.35405110219002983 0.04113086708701753 0.09674005540329624 1.3617096653763425e-07 6.86591547991671 0.6882603665545609 VINAAHSFYNGTTTLPISDEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VINAAHSFYNGTTTLPISDEDR 22 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 17010300.0 3717100.0 6945400.0 6347800.0 False True 5091412.320850466 6638529.262633572 4848580.377044704 1.0 1.3038679337454793 0.9523055827139923 22.279634474281416 -6.678088989048987 1.9088932056775993 1.1925911731480396 0.9536694928654539 0.3153297013706978 0.12884079499998866 0.44276730353012866 3.117706998446879 0.05419461556126163 0.14327423119435992 2.0985098447055156e-07 6.678088989048987 -0.23892168028258576 VINAAHSFYNGTTTLPISDEDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VINAAHSFYNGTTTLPISDEDR 22 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 8720600.0 4807100.0 1435900.0 2477600.0 False True 3997316.64063809 1428164.521696164 2995654.7048719204 1.0 0.35728080862470446 0.7494164146060056 21.930600427242627 -10.803096826516441 7.0460397367328 1.0183054792564512 0.553348611615525 0.633676892781043 0.16008869077187715 0.044038502810239175 0.0012306643182481544 0.148282582471099 0.051668402772969114 1.57363198206715e-11 10.803096826516441 -0.46495686764092625 VINDK(ub)HDDVMAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VINDKHDDVMAK 12 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 35903100.0 9756500.0 12911600.0 13235000.0 True False 12790865.982080411 10985239.609022612 11865569.159084588 1.0 0.8588347047348144 0.9276595639191174 23.60861060675474 -10.22245087990097 4.807529571226827 1.000019511415991 0.8932471343267046 0.7623460591588086 0.028097631104309143 5.877081924902059e-06 9.50557340491515e-07 0.027210385420928414 0.009068471444444266 5.99168702681397e-11 10.22245087990097 -0.10677237708928655 VINDK(ub)HDDVMAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VINDKHDDVMAK 12 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 35333400.0 10433100.0 12690200.0 12210100.0 True False 10101906.951290218 17757463.038518734 9011908.514851712 1.0 1.7578327660453006 0.8920997350604886 23.268124322484063 -6.675464298063701 1.9182156235968075 1.481441794785125 0.895521390003204 0.3033507642185649 0.32151341559070207 0.44870860803634155 3.188104126892244 0.13469623668730063 0.35730217153363436 2.1112307460852979e-07 6.675464298063701 -0.5859204047819211 VINDK(ub)HDDVMAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VINDKHDDVMAK 12 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 42483000.0 11260000.0 16247000.0 14976000.0 True False 17082243.21626542 13347595.911609601 12015987.035786022 1.0 0.7813725482435613 0.7034197373061989 24.025994104303475 -13.999999999999998 0.143622548532417 2.048168788851142 0.6110331964062647 0.9995888931319649 0.002545340382177726 11.93943175833409 0.1189877632663668 3.5008103163092614 0.08280970023858356 1.0000000000000041e-14 13.999999999999998 -1.4371355924448774 VINDK(ub)HDDVMAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VINDKHDDVMAK 12 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 30994700.0 9756500.0 8593900.0 12644300.0 True False 13363741.709498703 8214193.08177307 9657976.757532755 1.0 0.6146626641200773 0.7227000466993493 23.671820668277633 -10.268579478865131 8.106695144673207 1.0000003898007666 0.6686813554097146 0.9261423680490074 0.04410607674417812 3.107271221431467e-07 2.802396456371553e-08 0.04270557544454203 0.014235175058062344 5.38791233863722e-11 10.268579478865131 -0.3313190343910519 VINDK(ub)HDDVMAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VINDKHDDVMAK 12 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 24267200.0 6546500.0 11972000.0 5748700.0 True False 5443704.809123439 11907504.459744047 6950726.5910143675 1.0 2.1873898158084417 1.2768375278845425 22.376157406562818 -10.398273555194649 5.1065661673514295 0.9993808118948305 1.7321136718465406 0.4629308924350424 0.3717314149230605 0.0026225663190034055 0.000309026447261403 0.3602124621440017 0.11997579827157005 3.996929102402044e-11 10.398273555194649 0.7327328599517101 VINDK(ub)HDDVMAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VINDKHDDVMAK 12 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 34927800.0 11260000.0 13832000.0 9835800.0 True False 14576291.967782797 13062237.040694812 8045785.323830539 1.0 0.8961289379744575 0.551977508519568 23.797120426395924 -6.949199075640825 0.5675678681270702 1.0043352155542198 0.4271085648233846 0.9991369261383249 0.005625082623540801 0.08380894503117095 0.037305640602737215 0.005976096131407113 0.02865770915510548 1.1240895859970578e-07 6.949199075640825 -0.5772266507308352 VINDPIHGHIELHPLLVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VINDPIHGHIELHPLLVR 18 0 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8Y6J9 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 30680000.0 10044000.0 10052000.0 10584000.0 False True 13167781.266234353 8552280.782389108 9488869.208896965 1.0 0.6494853316191848 0.7206126086882165 23.65050894026446 -10.832631536721525 7.289809821323851 1.0189739942827436 0.6850489701537006 0.963157843180073 0.029037589268781742 0.0086206841123576 0.00019792409226979563 0.027067650605300444 0.00937184163766691 1.470173070041165e-11 10.832631536721525 -0.333925024129043 VINDPIHGHIELHPLLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VINDPIHGHIELHPLLVR 18 0 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8Y6J9 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 34891000.0 13070000.0 7670000.0 14151000.0 False True 12655100.004156299 10732670.998521611 10444428.5790998 1.0 0.8480905717850269 0.8253137925160251 23.593215572286788 -13.999999999999998 0.26718457566280907 2.154969628639183 0.8175446402702832 0.9995773057787604 0.0015941527619866525 14.747044232509056 0.16360878822959743 9.235997295893801 0.009594794000897924 1.0000000000000041e-14 13.999999999999998 -1.3374249883688996 VINDPIHGHIELHPLLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VINDPIHGHIELHPLLVR 18 0 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8Y6J9 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 34333000.0 10044000.0 13274000.0 11015000.0 False True 13757538.22889405 12687510.788751993 8413483.861045942 1.0 0.9222224628898542 0.6115544598942605 23.71371900178735 -6.944908075900708 0.6122094553825465 1.0034261208822806 0.5141109411233802 0.9987385726442722 0.0059601768420042365 0.0855973506522274 0.04493862456782909 0.006045774233782616 0.026216797838821145 1.1352510809622537e-07 6.944908075900708 -0.4893151797589004 VINDPIHGHIELHPLLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VINDPIHGHIELHPLLVR 18 0 Q9Y3Z3;A0A2R8YCS7;Q9Y3Z3-4;Q9Y3Z3-3;A0A2R8YD90;A0A2R8YF51;A0A2R8Y5D2;A0A2R8Y586;A0A2R8Y6J9 Q9Y3Z3 SAMHD1 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 0 26823700.0 13070000.0 5722900.0 8030800.0 False True 10868284.099174108 5692069.601793294 9710003.14977615 1.0 0.5237321319402977 0.8934255914890946 23.373620847721064 -9.828634108202198 6.33556860807569 1.000000011047196 0.7085788617146105 0.4531063693978933 0.1509267228567767 2.3484678965327443e-08 4.468169970838322e-09 0.14613417756305594 0.04871139034345106 1.4837676284783913e-10 9.828634108202198 -0.29142114933258556 VINEEYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VINEEYK 7 0 Q09028-3;Q09028;Q09028-2;E9PNS6;E9PNS2;E9PIC4;C9JAJ9;Q16576;E9PC52;Q16576-2 Q09028-3;Q16576 RBBP4;RBBP7 Histone-binding protein RBBP4;Histone-binding protein RBBP7 0 5896590.0 2365300.0 714790.0 2816500.0 False True 2290214.846199762 1000209.3745806067 2078774.1568111496 1.0 0.4367316787943677 0.9076764829555342 21.127051513938035 -10.13489022439266 7.584725145723981 1.0000000899463772 0.6722040808749552 0.39245191799645374 0.19226241120163498 2.9231599059887297e-07 3.364715495994436e-08 0.18615732910222166 0.06205242639046789 7.330097909064224e-11 10.13489022439266 -0.32779600907142203 VINEEYK(ub)IWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VINEEYKIWK 10 1 Q09028-3;Q09028;Q09028-2;E9PNS6;E9PNS2;E9PIC4;C9JAJ9;Q16576;E9PC52;Q16576-2 Q09028-3;Q16576 RBBP4;RBBP7 Histone-binding protein RBBP4;Histone-binding protein RBBP7 1 51067500.0 26084000.0 21644000.0 3339500.0 True False 25255977.697659716 30286562.071968887 2464784.7671474656 1.0 1.1991839094304917 0.09759213429206738 24.59012155600097 -6.860099624433823 1.1851525656381023 1.1081058807991142 0.044126248024711635 0.9537660594898719 0.10305852319165916 0.14670429944889182 0.3914819189263755 0.06781758847558586 0.15833264434478087 1.3800676494151692e-07 6.860099624433823 -1.0639796327744027 down VINEEYK(ub)IWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VINEEYKIWK 10 1 Q09028-3;Q09028;Q09028-2;E9PNS6;E9PNS2;E9PIC4;C9JAJ9;Q16576;E9PC52;Q16576-2 Q09028-3;Q16576 RBBP4;RBBP7 Histone-binding protein RBBP4;Histone-binding protein RBBP7 1 431802000.0 65207000.0 179626000.0 186969000.0 True False 98923786.27025037 147570336.87565625 150014495.198576 1.0 1.491757871787359 1.516465360401296 26.559814123599477 -11.596262632612314 0.48241055373423186 1.681119830855977e-13 1.5157146200966396 0.9998461721554095 0.0029500403778887213 4.496113214729288 0.2382338527363263 4.6776250955259995 0.0052023123569501445 2.533596015636545e-12 11.596262632612314 1.5157146200964715 VINEEYK(ub)IWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VINEEYKIWK 10 1 Q09028-3;Q09028;Q09028-2;E9PNS6;E9PNS2;E9PIC4;C9JAJ9;Q16576;E9PC52;Q16576-2 Q09028-3;Q16576 RBBP4;RBBP7 Histone-binding protein RBBP4;Histone-binding protein RBBP7 1 27645910.0 11079000.0 15655000.0 911910.0 True False 15175205.698717369 14963310.335837899 696535.6393759792 1.0 0.98603673867186 0.04589958470446641 23.85521273644262 -6.988302998238381 0.9954352202661465 1.0216864047726653 3.886139314566052e-23 0.9897935513281717 0.04510980118607308 0.08824272663474138 0.16057790939764915 0.036385336088179794 0.07724232464093288 1.027299322648888e-07 6.988302998238381 -1.0216864047726653 down VINEEYK(ub)IWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VINEEYKIWK 10 1 Q09028-3;Q09028;Q09028-2;E9PNS6;E9PNS2;E9PIC4;C9JAJ9;Q16576;E9PC52;Q16576-2 Q09028-3;Q16576 RBBP4;RBBP7 Histone-binding protein RBBP4;Histone-binding protein RBBP7 1 65354000.0 26084000.0 26890000.0 12380000.0 True False 21690001.71712755 26745138.23275292 14968600.761347426 1.0 1.233062983652674 0.6901152409558107 24.370526831435246 -6.79005582611392 1.4959482120266823 1.1302555300667405 0.6843213812094117 0.8015044811465455 0.09908365162758419 0.2352979081820111 1.0402194702408145 0.05213178972462593 0.1220568256959081 1.6216016361877403e-07 6.79005582611392 -0.44593414885732885 VINEEYK(ub)IWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VINEEYKIWK 10 1 Q09028-3;Q09028;Q09028-2;E9PNS6;E9PNS2;E9PIC4;C9JAJ9;Q16576;E9PC52;Q16576-2 Q09028-3;Q16576 RBBP4;RBBP7 Histone-binding protein RBBP4;Histone-binding protein RBBP7 1 235867000.0 65207000.0 55590000.0 115070000.0 True False 84411746.92213255 52496367.632462725 94128440.71790595 1.0 0.6219083190031494 1.1151106824591224 26.330940445691926 -6.701926560293197 1.8245615198195382 0.7656582994856085 1.1136708401458077 0.42650731560919 0.1595420550495701 0.3915078555843631 2.535327024942391 0.06973272971247332 0.1788715183014134 1.9864307967378057e-07 6.701926560293197 0.34801254066019927 VINEPTAAALAYGLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VINEPTAAALAYGLDK 16 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 31122800.0 4453800.0 12884000.0 13785000.0 False True 5838974.93066056 10961757.421438646 12358660.435057154 1.0 1.8773427787604062 2.116580492606949 22.47728368633069 -10.67878102336679 0.2656589527688984 4.977379604222645e-12 2.220552739812061 0.9991553827998826 0.013950295788790944 2.392417794362675 0.1340209697885455 1.6459489119009352 0.10051488985551556 2.09516859941228e-11 10.67878102336679 2.2205527398070837 VINEPTAAALAYGLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VINEPTAAALAYGLDK 16 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 30815700.0 11378000.0 3711700.0 15726000.0 False True 11016811.618002327 5193801.166259793 11606888.830112612 1.0 0.47144322208185147 1.0535615232946394 23.393203417298754 -6.667648056334263 1.9455062118096453 0.6619503677333411 1.0511969956236125 0.26876676128077504 0.22464070750128945 0.46653419517891814 3.401993744298662 0.0930276906625905 0.24932996388465717 2.1495717389499923e-07 6.667648056334263 0.3892466278902713 VINEPTAAALAYGLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VINEPTAAALAYGLDK 16 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 41081800.0 4453800.0 20454000.0 16174000.0 False True 6100490.219419397 19550274.647667106 12354034.313986108 1.0 3.2047055145558065 2.025088782973556 22.54049374785358 -10.27303667366328 5.857887609569247 0.9999109414961357 2.6148971487646904 0.7141948312947328 0.4815765140710553 0.0005601540656224489 6.951323055690082e-05 0.4663094812448069 0.15542815157681358 5.3328986033434706e-11 10.27303667366328 1.6149862072685548 VINEPTAAALAYGLDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VINEPTAAALAYGLDK 16 0 P38646 P38646 HSPA9 Stress-70 protein, mitochondrial 0 16012000.0 11378000.0 2010300.0 2623700.0 False True 9461311.130864808 1999470.114886693 3172303.539381841 1.0 0.2113311873196936 0.3352921699227407 23.17360869273303 -9.954158185435542 5.713229781997428 1.0000007695087711 0.273311678830801 0.9786420868230271 0.05060685923394568 4.960423939857267e-07 9.073873335345263e-08 0.04899993258918774 0.016333293584448676 1.111326868938872e-10 9.954158185435542 -0.7266890906779702 VINHK(ub)LYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VINHKLYK 8 1 P22102;A0A140TA71 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 9193230.0 2326800.0 5072800.0 1793630.0 True False 3050457.33276325 4315958.013619531 1608042.3733138593 1.0 1.4148560503581704 0.5271479643536655 21.540594120933545 -6.779631036011608 1.5373803441027594 1.2350135224956242 0.5202058156397593 0.7660631261258996 0.1754093027252184 0.25114561609162517 1.1724480264041879 0.08986842667493573 0.21211086801273868 1.660997443402486e-07 6.779631036011608 -0.7148077068558649 VINHK(ub)LYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VINHKLYK 8 1 P22102;A0A140TA71 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 12400100.0 4381000.0 4725800.0 3293300.0 True False 4241927.553038155 6612836.584721435 2430685.9331177548 1.0 1.5589225657532002 0.5730144852136496 22.01628855092694 -6.752921390349167 1.639151061760129 1.3274946518055213 0.5706230340836204 0.6614095562792206 0.234904080145234 0.2949708918138733 1.5601795641129743 0.11316911697557322 0.2738939132833789 1.7663575120183375e-07 6.752921390349167 -0.7568716177219009 VINHK(ub)LYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VINHKLYK 8 1 P22102;A0A140TA71 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 9630300.0 2326800.0 4146400.0 3157100.0 True False 3187080.8394056815 3963198.3376888074 2411458.002515493 1.0 1.2435198657928785 0.7566353425052047 21.603804182456436 -6.770727633103504 1.5718135253775027 1.1395460455675097 0.7538299020214697 0.7332992437801484 0.10265083228890154 0.26524650791958215 1.2934161022136492 0.051475347722821245 0.12244381874370264 1.6954007342086682e-07 6.770727633103504 -0.38571614354604 VINHK(ub)LYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VINHKLYK 8 1 P22102;A0A140TA71 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 11047050.0 4381000.0 5035600.0 1630450.0 True False 3642995.611207476 5008472.223311656 1971369.5566509617 1.0 1.374822469701409 0.5411397012354754 21.796693826361217 -6.784480588122269 1.5183795456834122 1.2109996632948494 0.5335793271220857 0.7829335139406092 0.15883852374149265 0.2436747504715047 1.10984252503571 0.08237060849768098 0.19364791095496217 1.6425530760504555e-07 6.784480588122269 -0.6774203361727638 VINK(ub)EGEVMDVYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VINKEGEVMDVYR 13 1 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-9;Q9UKT9-10;Q9UKT9-11;Q9UKT9-16;Q9UKT9-12 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 11478700.0 1120100.0 2034100.0 8324500.0 True False 1468461.947063831 1730620.2088596968 7463160.594242513 1.0 1.1785257441093708 5.082297576157829 20.485874450244953 -6.916458318524891 0.8505678661349131 0.9023900774163428 5.663267465438694 0.9931395155745665 0.15602691449421877 0.10030082178451791 0.11673944203722819 0.13197038559459912 0.38287341026155586 1.2121090155289819e-07 6.916458318524891 4.760877388022351 up VINQILTEMDGMSTK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 VINQILTEMDGMSTKK 16 1 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 1 19103000.0 6562200.0 6507700.0 6033100.0 True False 8603107.748435207 5536776.526815918 5408852.685581668 1.0 0.6435786565410605 0.6287091646115287 23.036426476040358 VIPELNGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIPELNGK 8 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 101443100.0 4645100.0 58433000.0 38365000.0 False True 6089771.083212386 49715024.17005008 34395357.823066175 1.0 8.16369342800077 5.648054311578892 22.537956567025333 -9.548232325361985 9.374245780888174 0.9999999960641902 6.905873869789833 0.880220842451259 1.0270053687032616 0.0 0.0 0.9943936649545217 0.33146455745444386 2.8298777507806086e-10 9.548232325361985 5.905873873725643 VIPELNGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIPELNGK 8 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 99345000.0 27244000.0 10641000.0 61460000.0 False True 26379154.132611606 14890006.792081937 45361782.23952181 1.0 0.5644611164265481 1.7196071569043474 24.652894968442705 -6.8045611924045 1.4372149703079955 0.7610624588651212 1.7374066546012794 0.845154010817412 0.1874325432294497 0.2143183123054126 0.8734459421049716 0.10257361816106839 0.23791747474081756 1.5683349025969976e-07 6.8045611924045 0.9763441957361582 VIPELNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIPELNGK 8 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 85560100.0 4645100.0 44266000.0 36649000.0 False True 6362518.999107502 42310181.75191313 27993261.00984775 1.0 6.649910476942884 4.3997135432954275 22.601166628548224 -9.541891676697206 8.132979705735867 1.0000000009705554 5.524812009473672 0.8435389075397608 0.9186390513691333 0.0 0.0 0.8894684367818696 0.2964894789272898 2.871496711822237e-10 9.541891676697206 4.524812008503117 VIPELNGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIPELNGK 8 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 29753300.0 27244000.0 1354200.0 1155100.0 False True 22654593.113840777 1346904.6558123445 1396626.0694210336 1.0 0.05945393276515992 0.061648693596168265 24.43330024387698 VIPELNGK(ub)LTGMAFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIPELNGKLTGMAFR 15 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 10861100.0 2732500.0 1572400.0 6556200.0 True False 2645758.2831948763 2200267.519957675 4838934.538215969 1.0 0.8316207621584953 1.8289405230067843 21.335249832163257 -6.86346867786946 1.1681660577930943 0.9076676788561506 1.880516098986196 0.9577142890896353 0.0896378599564065 0.14326662081863276 0.3695561307345694 0.059761271618273826 0.1400837573495916 1.3694031487468252e-07 6.86346867786946 0.9728484201300454 VIPELNGK(ub)LTGMAFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIPELNGKLTGMAFR 15 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 120778000.0 5157500.0 6920500.0 108700000.0 True False 7824304.563755674 5685482.704886699 87215397.35509762 1.0 0.7266438388944386 11.14672833149968 22.89953109810973 -6.900875674949306 0.9557105401781965 0.577118861106718 12.260171624480384 0.9869970929215965 0.5529247393977621 0.11076374387713381 0.17380480888126562 0.43318766211995086 1.1321194783678266 1.2563895776178234e-07 6.900875674949306 11.683052763373666 up VIPELNGK(ub)LTGMAFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIPELNGKLTGMAFR 15 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 13945100.0 2732500.0 2621600.0 8591000.0 True False 2272194.8202749197 2607476.920453142 10387338.37970401 1.0 1.1475586939933502 4.571499893854707 21.115655107597533 -6.915942102167215 0.8542864818819766 0.9128518362361281 5.075194953208349 0.9929773716759691 0.13826693973083853 0.1006184439157824 0.11842330055968853 0.11663865819368498 0.3369103831265456 1.2135506238025472e-07 6.915942102167215 4.162343116972221 up VIPELNGK(ub)LTGMAFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIPELNGKLTGMAFR 15 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 90907800.0 5157500.0 6156300.0 79594000.0 True False 6676485.419523957 5813696.493177373 65108708.70340666 1.0 0.8707719897322711 9.751943517020218 22.67065742020218 -6.903599125398678 0.9382314407745552 0.6663251953815049 10.7554281101319 0.9882734870450212 0.4501033221136488 0.10880436784837409 0.16285421645310255 0.3572202598471334 0.9473890411932351 1.2485354405125267e-07 6.903599125398678 10.089102914750395 up VIPHFTATADAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIPHFTATADAFK 13 0 Q14554;H7C4F9 Q14554 PDIA5 Protein disulfide-isomerase A5 0 12062200.0 3049400.0 4261800.0 4751000.0 False True 3997792.9304316044 3625956.0523662884 4259412.094810041 1.0 0.9069894603007435 1.0654408992489242 21.93077231755078 -6.747652877144217 1.6588736327174303 0.9451539432226868 1.0656937974738931 0.6386727586710148 0.03907970119998154 0.3041547097043468 1.6460957296239398 0.018617028262183595 0.045302996475885295 1.7879160492851571e-07 6.747652877144217 0.12053985425120639 VIPHFTATADAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIPHFTATADAFK 13 0 Q14554;H7C4F9 Q14554 PDIA5 Protein disulfide-isomerase A5 0 5204200.0 1587500.0 1087500.0 2529200.0 False True 1537105.681453565 1521744.4212375798 1866726.6456264018 1.0 0.9900063734059855 1.2144426165032 20.55178492815088 -6.896479357661616 0.983263115847692 0.9897461796199211 1.2363862368249159 0.9847316538304048 0.012792101038665503 0.11404316254350358 0.19239771893972807 0.00981848419541753 0.025123209357092943 1.269172467718974e-07 6.896479357661616 0.24664005720499482 VIPHFTATADAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIPHFTATADAFK 13 0 Q14554;H7C4F9 Q14554 PDIA5 Protein disulfide-isomerase A5 0 4448400.0 1587500.0 1570700.0 1290200.0 False True 1320076.5881743587 1562238.3273404604 1559974.854789213 1.0 1.1834452192664116 1.1817305668200881 20.332190203585156 -10.014644939051982 4.583593408036269 0.9999944413254358 1.1825878930534393 0.9999338590563556 0.0007000039734118994 483145.3880415626 0.00035757023762567026 28.346692422365443 0.00023962997261642562 9.668410046015535e-11 10.014644939051982 0.18259345172800345 VIPSFMCQAGDFTNHNGTGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIPSFMCQAGDFTNHNGTGGK 21 0 P30405;R4GN99;H0Y548;P30405-2 P30405 PPIF Peptidyl-prolyl cis-trans isomerase F, mitochondrial;Peptidyl-prolyl cis-trans isomerase 0 10769000.0 0.0 4981200.0 5787800.0 False True 0.0 4238024.376565519 5188933.976497905 0.0 VIPSFMCQAGDFTNHNGTGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIPSFMCQAGDFTNHNGTGGK 21 0 P30405;R4GN99;H0Y548;P30405-2 P30405 PPIF Peptidyl-prolyl cis-trans isomerase F, mitochondrial;Peptidyl-prolyl cis-trans isomerase 0 9559900.0 0.0 4431200.0 5128700.0 False True 0.0 4235414.931981151 3917406.6888920893 0.0 VIQCFAETGQVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIQCFAETGQVQK 13 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 6417910.0 416210.0 3768100.0 2233600.0 False True 545655.3405833736 3205914.1679387596 2002488.498204107 1.0 5.875346449484463 3.669877941748352 19.057630444928616 -9.886197949443464 8.439740740280776 1.000010240762973 4.772612195616407 0.7959769828208867 0.9003787479745735 2.6280381679387508e-08 6.156896711204548e-09 0.8717879610468569 0.2905959913457925 1.299577101705666e-10 9.886197949443464 3.7726019548534344 VIQCFAETGQVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIQCFAETGQVQK 13 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 4166310.0 416210.0 1697800.0 2052300.0 False True 570094.0846523294 1622785.5821261953 1567589.008445264 1.0 2.8465224000979545 2.749702287125562 19.120840506451508 -10.203953940560249 4.6657712956000905 0.9996527454329633 2.7981123436229316 0.9978302212472258 0.039526645641751505 0.00014280406550196725 2.4364420178960818e-05 0.038278353119202364 0.012757170019752878 6.252389994688965e-11 10.203953940560249 1.7984595981899683 VIQELGLDK(ub)VADSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIQELGLDKVADSK 14 1 Q9UNQ0-2;Q9UNQ0 Q9UNQ0-2 ABCG2 ATP-binding cassette sub-family G member 2 1 15315000.0 4105200.0 7065900.0 4143900.0 True False 5381956.954813345 6011695.262662473 3715128.979095627 1.0 1.1170091684374996 0.6902933282981772 22.35969942159465 -6.833602702968608 1.3116164272031614 1.0623852212724059 0.6779325863845818 0.9129073845920177 0.05312934717446586 0.17640931357281936 0.5922298546433032 0.031790604688654245 0.0731667768281207 1.466889152530838e-07 6.833602702968608 -0.3844526348878241 VIQELGLDK(ub)VADSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIQELGLDKVADSK 14 1 Q9UNQ0-2;Q9UNQ0 Q9UNQ0-2 ABCG2 ATP-binding cassette sub-family G member 2 1 8854000.0 2879900.0 3894600.0 2079500.0 True False 2788479.150877561 5449734.09007069 1534816.5663372234 1.0 1.95437505364012 0.5504134990050766 21.411047053486158 -6.72365627365937 1.745949675764943 1.5783619574327086 0.5521135060798615 0.5297214017899449 0.40143784452474474 0.34830516663264743 2.076857000811738 0.18241845506751642 0.4560172154372738 1.8894862086029717e-07 6.72365627365937 -1.026248451352847 VIQELGLDK(ub)VADSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIQELGLDKVADSK 14 1 Q9UNQ0-2;Q9UNQ0 Q9UNQ0-2 ABCG2 ATP-binding cassette sub-family G member 2 1 14896800.0 4105200.0 7269500.0 3522100.0 True False 5623003.3788586045 6948309.452978188 2690252.51992646 1.0 1.2356936293338319 0.4784369381745856 22.422909483117543 -6.823083101820056 1.3583660964046904 1.126662950967125 0.46077218459970404 0.8913346762502282 0.10430155353838362 0.1895181275744782 0.6862477803636561 0.060323474893353254 0.1389428697641825 1.5028543688764216e-07 6.823083101820056 -0.6658907663674211 down VIQELGLDK(ub)VADSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIQELGLDKVADSK 14 1 Q9UNQ0-2;Q9UNQ0 Q9UNQ0-2 ABCG2 ATP-binding cassette sub-family G member 2 1 7026500.0 2879900.0 2524500.0 1622100.0 True False 2394764.451202105 2510900.017425981 1961273.6102569995 1.0 1.0484956114016053 0.8189839335858251 21.191452328920434 -6.8515009739319686 1.227832630607832 1.0259158293642825 0.8095401782536361 0.9424607329100727 0.02369157507909106 0.15581328109497564 0.45127291782924545 0.01509268607540777 0.034960361763413814 1.4076640715858492e-07 6.8515009739319686 -0.21637565111064638 VIQIATSSSTAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIQIATSSSTAK 12 0 H7BXY3;Q7L2E3-3;Q7L2E3;Q7L2E3-2 H7BXY3 DHX30 Putative ATP-dependent RNA helicase DHX30 0 2064520.0 806920.0 0.0 1257600.0 False True 1105260.1301930693 0.0 960580.7810850099 1.0 0.0 0.8690992779385007 20.075954526608534 -9.06023016250095 11.578669379713412 0.9999990117574588 0.4345496389687318 0.36077831679596895 0.3548082944623517 0.0 0.0 0.3435416538869739 0.11451388462899127 8.70502128767347e-10 9.06023016250095 -0.565449372788727 VIQIVINR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIQIVINR 8 0 O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O94973 AP2A2 AP-2 complex subunit alpha-2 0 5306900.0 1303000.0 2378900.0 1625000.0 False True 1708245.6182699513 2023977.3928795734 1456860.588100677 1.0 1.1848280898442367 0.8528402312403599 20.704083995561096 -6.755604277470926 1.6290414045605912 1.107943226254407 0.8518848716230604 0.672761619258152 0.07769776717417118 0.2903640110003871 1.51762614041222 0.03765146438886431 0.09087858957284846 1.7554793393973702e-07 6.755604277470926 -0.25605835463134674 VIQIVINR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIQIVINR 8 0 O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O94973 AP2A2 AP-2 complex subunit alpha-2 0 4445800.0 1395200.0 1226700.0 1823900.0 False True 1350910.1396938695 1716527.7071559925 1346165.8741728577 1.0 1.27064536472054 0.9964880968899331 20.365500281493556 -6.6491397372637895 2.011333416571001 1.1757459959508352 0.9976365290513506 0.1905223016507186 0.11554002490802956 0.510754529067524 3.959434192614236 0.046600378201284924 0.1279908876324511 2.2431600553393614e-07 6.6491397372637895 -0.1781094668994846 VIQIVINR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIQIVINR 8 0 O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O94973 AP2A2 AP-2 complex subunit alpha-2 0 5399800.0 1303000.0 1231700.0 2865100.0 False True 1784754.3122509932 1177279.4213127792 2188422.3885867205 1.0 0.6596310838033242 1.2261757114493856 20.767294057083987 -6.743991631717992 1.6718675944082524 0.7984284408638121 1.2268207727449 0.6228352912595554 0.14300293617840795 0.31063133630812384 1.7062378089134158 0.06762328945764928 0.1652337736458616 1.8030524829687025e-07 6.743991631717992 0.42839233188108794 VIQIVINR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIQIVINR 8 0 O94973;O94973-2;A0A0G2JS82;O94973-3;A0A0G2JQM1 O94973 AP2A2 AP-2 complex subunit alpha-2 0 3057940.0 1395200.0 949410.0 713330.0 False True 1160170.6178399173 944295.339886869 862484.0049347297 1.0 0.813927990733829 0.7434113497379891 20.145905556927833 -13.999999999999998 0.1345450953609644 1.8855064244998412 0.6501299329774711 0.9996255456988992 0.002094426125247969 11.932292009970512 0.1144918317621714 2.7838745775787737 0.08312387763748612 1.0000000000000041e-14 13.999999999999998 -1.23537649152237 VIQLLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIQLLFK 7 0 O95239-2;O95239;Q2VIQ3 O95239-2 KIF4A;KIF4B Chromosome-associated kinesin KIF4A;Chromosome-associated kinesin KIF4B 0 5627400.0 1977900.0 1828300.0 1821200.0 False True 2593046.0540108494 1555524.7666575836 1632759.694183973 1.0 0.5998832007829334 0.6296686060235864 21.3062163988486 -9.947162185666013 5.256148896427274 1.00000112678516 0.6147759034006387 0.9955362631704114 0.012159840779433526 1.605629633398771e-07 3.2143621486193777e-08 0.01177374958828452 0.00392457173461912 1.1293740753443276e-10 9.947162185666013 -0.38522522338452136 VIQLLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIQLLFK 7 0 O95239-2;O95239;Q2VIQ3 O95239-2 KIF4A;KIF4B Chromosome-associated kinesin KIF4A;Chromosome-associated kinesin KIF4B 0 7963400.0 1977900.0 2489000.0 3496500.0 False True 2709183.080737713 2379027.749977679 2670698.7126779086 1.0 0.8781347288385796 0.9857948440866076 21.369426460371493 -10.236598672007132 5.190878776763258 1.000007413230941 0.9319647868695595 0.34745941323061524 0.04395205800121811 3.771211158234074e-06 5.546243141709719e-07 0.042561034154878344 0.014185465722511859 5.799643892416576e-11 10.236598672007132 -0.06804262636138136 VIQQYHLQYLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIQQYHLQYLAR 12 0 P55160;P55160-2;F8W050 P55160 NCKAP1L Nck-associated protein 1-like 0 12787100.0 4453300.0 4960000.0 3373800.0 False True 5838319.425818553 4219987.333928568 3024711.5397748123 1.0 0.722808573177188 0.5180791455840457 22.47712171497723 -7.4293084003141265 0.13527891907660056 1.3287334434680733 1.557853362326194e-11 0.9999928752468742 0.0005270954494871049 0.12535868289979307 0.010433523988197321 0.03595295104115822 0.060900354759818816 3.721273580838755e-08 7.4293084003141265 -1.3287334434524949 VIQVSPFLLALSGNSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIQVSPFLLALSGNSR 16 0 O95059 O95059 RPP14 Ribonuclease P protein subunit p14 0 7337380.0 775680.0 2299100.0 4262600.0 False True 1062469.857963812 2197518.159893003 3255861.6710026762 1.0 2.0683110616469373 3.064427330900875 20.018990482214075 -6.971967694260563 0.20583357680863953 0.44993768973561704 4.710479539437782 0.9999939350228141 0.0020759906059813695 0.07566923232039484 0.006694536475888415 0.030840032681198545 0.1042403499740525 1.0666754647619457e-07 6.971967694260563 4.2605418497021645 VIQYLAYVASSHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIQYLAYVASSHK 13 0 P35579;P35579-2;Q5BKV1 P35579 MYH9 Myosin-9 0 161704700.0 51861000.0 76597800.0 33245900.0 False True 67990273.22263849 65169706.81588591 29805933.185191605 1.0 0.9585151482254461 0.43838525383756255 26.018825031498206 -6.922771054243818 0.8039078931976605 1.0103709974811232 0.34892008429976923 0.9949166574622197 0.018218773878169957 0.09656872329469529 0.09736595354113503 0.01593222023211798 0.04906563832974813 1.1946177016300432e-07 6.922771054243818 -0.661450913181354 down VIQYLAYVASSHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIQYLAYVASSHK 13 0 P35579;P35579-2;Q5BKV1 P35579 MYH9 Myosin-9 0 176956900.0 65506700.0 27548700.0 83901500.0 False True 63427225.66505472 38549039.57457262 61925180.1589529 1.0 0.6077680234374692 0.9763185999331928 25.91859890364226 -10.550092043398221 9.090083186856297 1.000016915005266 0.7920433126790548 0.29800538521476716 0.15046014280385037 5.158208258964046e-05 2.5530953081784877e-06 0.14569423777512358 0.04856080227894182 2.8177856728016582e-11 10.550092043398221 -0.2079736023262112 VIQYLAYVASSHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIQYLAYVASSHK 13 0 P35579;P35579-2;Q5BKV1 P35579 MYH9 Myosin-9 0 239201800.0 55560800.0 66617000.0 117024000.0 False True 84289795.63856842 54728675.8690033 93894155.10655874 1.0 0.6492918324737419 1.1139445100706313 26.328854649201823 -6.704768465771733 1.8135299368260622 0.7832580497887812 1.1127103370420064 0.4404311526041773 0.14791214603148334 0.3856606737168814 2.4690260949468583 0.0649827768373371 0.16616259859161459 1.9734745688041307e-07 6.704768465771733 0.3294522872532252 VIQYLAYVASSHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIQYLAYVASSHK 13 0 P35579;P35579-2;Q5BKV1 P35579 MYH9 Myosin-9 0 203236200.0 51861000.0 57464200.0 93911000.0 False True 71035413.1908279 54925241.63530222 71731155.95775631 1.0 0.7732092933386945 1.009794308721192 26.082035093021098 -11.06866067851436 10.78348543660616 1.5967933238251395 0.8915018010297721 0.21900639744791672 0.09658542807927135 0.042430362607691216 0.00027016324512441433 0.0028633772356333243 0.031172812869777675 8.53766915751206e-12 11.06866067851436 -0.7052915227953674 VIQYLAYVASSHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIQYLAYVASSHK 13 0 P35579;P35579-2;Q5BKV1 P35579 MYH9 Myosin-9 0 143039800.0 65506700.0 35968300.0 41564800.0 False True 54471723.48885756 35774531.62875143 50255807.50607858 1.0 0.6567541714752109 0.9226035874623764 25.699004179076535 -9.817472903071003 5.8635154210556095 1.000000024497232 0.7896788794682603 0.4548961934764564 0.10853256959946912 3.477144302197502e-08 7.077073946835729e-09 0.10508622038841896 0.03502873621471029 1.5223941166301678e-10 9.817472903071003 -0.2103211450289717 VIQYLAYVASSHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIQYLAYVASSHK 13 0 P35579;P35579-2;Q5BKV1 P35579 MYH9 Myosin-9 0 273613500.0 55560800.0 134682700.0 83370000.0 False True 71924550.86710364 127187489.34939167 68197515.44843854 1.0 1.7683459655437879 0.9481813181489084 26.099980971294272 -6.660926244446049 1.9703345204011131 1.4942130561161755 0.9516447020753112 0.23931960448505407 0.32707480487604057 0.48220302940686716 3.599888088913509 0.13409263571575303 0.36245041970574227 2.183100632935405e-07 6.660926244446049 -0.5425683540408643 VISELNGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VISELNGK 8 0 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 22413110.0 713110.0 11635000.0 10065000.0 False True 934894.1157670642 9899103.352874793 9023570.350297436 1.0 10.588475406921086 9.651970419017726 19.83444345194189 -10.480927481525857 6.7578696206572735 0.9971675035521443 10.120222912969274 0.9921539761549716 0.38232656032243006 0.016289740019113458 0.001251219296605887 0.3695788207120362 0.1233953667451276 3.304247107347346e-11 10.480927481525857 9.123055409417129 VISELNGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VISELNGK 8 0 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 25840000.0 6828300.0 3865700.0 15146000.0 False True 6611539.354122444 5409294.169359183 11178808.22973963 1.0 0.8181595661207652 1.6908026453430078 22.656554780543335 -6.8523194094480475 1.223737175705083 0.9027290191454512 1.7273006738198808 0.9436235293501702 0.08925523813822671 0.1549274064671094 0.4452809953806971 0.057034450875860634 0.13220064035680681 1.4050138021467954e-07 6.8523194094480475 0.8245716546744296 VISELNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VISELNGK 8 0 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 22229110.0 713110.0 11197000.0 10319000.0 False True 976766.0380731431 10702279.516472502 7881864.726475993 1.0 10.956850565346011 8.06934764237347 19.897653513464782 -9.400307134215275 9.89167441759123 1.0000045715957617 9.513099103859753 0.9205694940026512 1.1788181320159508 0.0 0.0 1.1413857993986092 0.3804619161249737 3.978257276315934e-10 9.400307134215275 8.513094532263992 VISELNGK(ub)NIEDVIAQGIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VISELNGKNIEDVIAQGIGK 20 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 41204800.0 17479100.0 18221000.0 5504700.0 True False 22915269.367845185 15502497.824901728 4935126.448810958 1.0 0.6765138814669535 0.21536410371574996 24.44980590883148 -7.299089396602464 0.41770686345511754 1.0269678274529659 1.3142738831208707e-14 0.9993668893605492 0.008101193269534622 0.10142707678864375 0.03473071994585993 0.012077058809197306 0.05276848772620895 5.022391963157308e-08 7.299089396602464 -1.0269678274529528 down VISELNGK(ub)NIEDVIAQGIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VISELNGKNIEDVIAQGIGK 20 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 283863700.0 107708700.0 98147400.0 78007600.0 True False 104289546.27526146 137338168.6519296 57575069.38216275 1.0 1.3168929538674923 0.5520694205553385 26.636019312041125 -6.7941987881265895 1.4796314286757748 1.176153086532416 0.5429830049210919 0.81458891449721 0.13510389261145475 0.22916065241303274 0.9909974402926927 0.07185610388017266 0.1677245096129859 1.606205881606135e-07 6.7941987881265895 -0.633170081611324 VISELNGK(ub)NIEDVIAQGIGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VISELNGKNIEDVIAQGIGK 20 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 315850100.0 83945500.0 118700600.0 113204000.0 True False 127351460.73810026 97517550.51797916 90829179.78092423 1.0 0.7657356260602705 0.7132166310028865 26.924240266708864 -13.999999999999998 0.210108378323243 2.355437992690774 0.6823154525999517 0.9994900708965684 0.0028152359602618957 12.749192420018579 0.14528474573314334 7.134134373226483 0.03108596812372094 1.0000000000000041e-14 13.999999999999998 -1.673122540090822 VISELNGK(ub)NIEDVIAQGIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VISELNGKNIEDVIAQGIGK 20 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 78994100.0 17479100.0 38437000.0 23078000.0 True False 23941595.62491658 36738726.24583844 17627451.706329394 1.0 1.5345145253227646 0.7362688762475 24.51301597035437 -6.726252098870118 1.7368799992575763 1.322998965365802 0.7370554826081845 0.5418482139235725 0.22477037386213233 0.3432912190884418 2.027089117989824 0.10262712502086009 0.25575144743598777 1.8782262292305522e-07 6.726252098870118 -0.5859434827576175 VISELNGK(ub)NIEDVIAQGIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VISELNGKNIEDVIAQGIGK 20 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 232103500.0 107708700.0 93888700.0 30506100.0 True False 89564556.35445388 93382902.93765211 36884784.46573026 1.0 1.0426323396063844 0.41182344854986874 26.4164245874754 -6.890721001973844 1.0180847479408122 1.0333104799362873 0.3567906560619128 0.9813565764287119 0.03930252483749672 0.11856100130433822 0.21843503719569107 0.029385812264037393 0.07345367304988351 1.2861126148283086e-07 6.890721001973844 -0.6765198238743746 down VISELNGK(ub)NIEDVIAQGIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VISELNGKNIEDVIAQGIGK 20 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 382393500.0 83945500.0 166817000.0 131631000.0 True False 108669104.56318924 157533487.30607176 107675508.64811572 1.0 1.4496621458260817 0.9908566844360464 26.695366588801313 -6.65079578335653 2.005934524599451 1.2916057599994757 0.9927941498835352 0.19721547749382518 0.191883957579661 0.5065648295572452 3.9079647802131223 0.07755979402332118 0.21251357708492458 2.234622753981331e-07 6.65079578335653 -0.2988116101159405 VISGHLGWVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VISGHLGWVR 10 0 O43660-2;O43660;D6RA26 O43660-2 PLRG1 Pleiotropic regulator 1 0 19568900.0 8683400.0 7047100.0 3838400.0 False True 11384021.490165204 5995700.1493806485 3441239.188532701 1.0 0.5266768122811791 0.30228677901790946 23.440506954635996 -10.710350411064624 0.15131552549085003 1.9033460476230792 8.928629024150838e-19 0.9996689096756282 0.005291735351126541 2.661244642214763 0.08273938742112046 1.0692194119110376 0.20241332793371022 1.948271999632513e-11 10.710350411064624 -1.9033460476230792 VISGHLGWVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VISGHLGWVR 10 0 O43660-2;O43660;D6RA26 O43660-2 PLRG1 Pleiotropic regulator 1 0 15187200.0 5393000.0 3288200.0 6506000.0 False True 5221802.166978945 4601195.407736466 4801883.424183687 1.0 0.8811508480411221 0.9195835595896962 22.31611637011455 -9.85845185172753 5.486184507193202 1.0000000544076055 0.9003672046795447 0.8996053090689077 0.01569008879018745 1.0448027532669152e-08 2.1456780971857527e-09 0.015191871521024681 0.005063954381700318 1.385313760906283e-10 9.85845185172753 -0.09963284972806086 VISGHLGWVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VISGHLGWVR 10 0 O43660-2;O43660;D6RA26 O43660-2 PLRG1 Pleiotropic regulator 1 0 24047000.0 8683400.0 4918600.0 10445000.0 False True 11893887.640061582 4701279.988364884 7978106.121527459 1.0 0.3952685724497514 0.6707736244838236 23.503717016158888 -10.4346354753108 6.1066006217712445 1.0001647562510594 0.5330210984668126 0.7929891436716807 0.11247446650706788 0.00025237605255742007 2.3365506482144633e-05 0.10894076829027226 0.036300977971286424 3.675907079847713e-11 10.4346354753108 -0.4671436577842468 VISGHLGWVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VISGHLGWVR 10 0 O43660-2;O43660;D6RA26 O43660-2 PLRG1 Pleiotropic regulator 1 0 13527200.0 5393000.0 3851600.0 4282600.0 False True 4484518.450409018 3830850.6663172594 5178071.8594948705 1.0 0.8542390244749377 1.1546550464125296 22.096521645548826 -6.774777119392818 1.5562289723513016 0.9169062703396389 1.1566560213813328 0.7484707565331731 0.06151841549521384 0.25877598128715873 1.2374485328805878 0.031147561719932798 0.07382220390696333 1.6796658040857023e-07 6.774777119392818 0.23974975104169394 VISGVLQLGNIVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VISGVLQLGNIVFK 14 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 98700000.0 41929000.0 40734000.0 16037000.0 False True 54969325.04101362 34656645.979888424 14377645.077766523 1.0 0.6304724672174975 0.2615576063020439 25.712123429089107 -7.503225470540596 0.3158509039899417 1.077709476721618 5.369908437774458e-12 0.9996230638124178 0.0058529491590310675 0.12305218905095762 0.03379810503464769 0.021988505080107072 0.06539053472657079 3.1388786745094526e-08 7.503225470540596 -1.077709476716248 down VISGVLQLGNIVFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VISGVLQLGNIVFK 14 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 769720000.0 368090000.0 188820000.0 212810000.0 False True 356405184.432279 264216810.68329185 157068676.83684734 1.0 0.7413382919896779 0.4407025590467867 28.408943082211085 -6.969149486115868 0.27774828603639073 1.06805293722623 0.10485495982751672 0.9999749678481885 0.0011434522961315092 0.07657962154470511 0.01001392508059789 0.005626131788638522 0.027673887941358697 1.073619803964491e-07 6.969149486115868 -0.9631979773987133 down VISGVLQLGNIVFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VISGVLQLGNIVFK 14 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 1010020000.0 313640000.0 347430000.0 348950000.0 False True 475814810.1553725 285428402.0170198 279979879.5497818 1.0 0.599872883157664 0.588421952352339 28.825824936715627 VISGVLQLGNIVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VISGVLQLGNIVFK 14 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 262212000.0 41929000.0 64583000.0 155700000.0 False True 57431284.38862 61729509.5125786 118926866.7421566 1.0 1.0748411805467177 2.070768014474737 25.775333490612 -6.92195624849284 0.8100848417776484 0.9795365218522623 2.238826682725041 0.9947073426301829 0.03550827708944373 0.09703427743315793 0.09974938356317856 0.030915335853603437 0.09441133702273134 1.1968610988980565e-07 6.92195624849284 1.2592901608727787 up VISGVLQLGNIVFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VISGVLQLGNIVFK 14 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 576927000.0 368090000.0 80337000.0 128500000.0 False True 306083144.15187395 79904208.63535394 155368755.88312963 1.0 0.26105393309638325 0.5076031099773267 28.18934835764536 -10.228737540885739 5.459667273609438 1.000037888955014 0.3843285215381073 0.8926390842301999 0.10065327997708842 4.6423125091270756e-05 6.558024076019094e-06 0.09746309311585499 0.03248570642434327 5.905578668118583e-11 10.228737540885739 -0.6157093674169067 VISGVLQLGNIVFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VISGVLQLGNIVFK 14 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 720330000.0 313640000.0 254350000.0 152340000.0 False True 406013162.7686859 240195198.9083808 124615683.14039984 1.0 0.5915946105550893 0.3069252294448296 28.596951258808076 -8.12745733507003 0.21979275728344475 1.2330744740846666 1.8928141787163152e-16 0.9997224405172198 0.004738895155067532 0.08932187855585462 0.0435949128721685 0.08901158830961932 0.10627796391669223 7.456631221002114e-09 8.12745733507003 -1.2330744740846664 down VISGVLQLGNIVFKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VISGVLQLGNIVFKK 15 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 26094500.0 10067000.0 6774100.0 9253400.0 False True 13197934.488966674 5763430.685234985 8295946.932880498 1.0 0.43669186947799665 0.6285791871308208 23.653808825939677 -10.21748806934159 4.865137484248633 1.0000728832208152 0.5326355283035086 0.8877622174842174 0.07833766939656818 110328208.86474368 11.984040377467611 90079.4076469602 0.02681706789383112 6.060548494470301e-11 10.21748806934159 -0.46743735491730665 VISGVLQLGNIVFKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VISGVLQLGNIVFKK 15 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 48089400.0 23079000.0 7321400.0 17689000.0 False True 22346369.7778059 10244873.200596623 13055720.241374912 1.0 0.4584580539238945 0.58424345301677 24.413537145331983 -9.961991199395628 7.075261122650279 1.0000000216687601 0.5213507534704575 0.9507557061300317 0.05135167414498378 1.7551985549934525e-08 2.6702880380650494e-09 0.04972104728399521 0.016573681563615623 1.091462453773105e-10 9.961991199395628 -0.47864926819830267 VISGVLQLGNIVFKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VISGVLQLGNIVFKK 15 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 196396000.0 61674000.0 53998000.0 80724000.0 False True 93563966.97335283 44361635.01170039 64768866.01741394 1.0 0.4741316176165837 0.6922415552972462 26.47944969532744 -10.25672770030217 5.596603875548972 1.0000288496835348 0.5831865864569047 0.8296234504218507 0.08904300919135005 3.205518200527086e-05 4.257170742392189e-06 0.08622147854428526 0.028738507641185244 5.5369716477466857e-11 10.25672770030217 -0.4168422632266301 VISGVLQLGNIVFKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VISGVLQLGNIVFKK 15 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 58602000.0 10067000.0 27801000.0 20734000.0 False True 13789041.950445682 26572659.894387044 15837056.230134048 1.0 1.927085289165298 1.1485247696720635 23.71701888746257 -10.138657472192177 4.240727210640646 0.9998841664312684 1.5378050294643653 0.38883326265650553 0.3178460013005427 45276711.78822562 36082312.47180449 44335.06793312278 0.1088071380022582 7.266788626810339e-11 10.138657472192177 0.5379208630330968 VISGVLQLGNIVFKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VISGVLQLGNIVFKK 15 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 43198400.0 23079000.0 8327400.0 11792000.0 False True 19191211.073055785 8282538.643340509 14257652.679952234 1.0 0.431579779504853 0.7429261564409447 24.19394242076626 -10.132144180898052 5.447030988956808 1.000007734752445 0.587252967972797 0.700890043585428 0.1271066261266869 1.1939404684592542e-05 1.902299195014461e-06 0.12307276742241588 0.04102348718171324 7.376592948592816e-11 10.132144180898052 -0.41275476677964795 VISGVLQLGNIVFKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VISGVLQLGNIVFKK 15 1 P35579;P35579-2 P35579 MYH9 Myosin-9 0 177648000.0 61674000.0 63198000.0 52776000.0 False True 79838208.7762909 59680975.74449325 43171309.52748943 1.0 0.7475239820537705 0.540734946201721 26.25057601741989 -6.9734059037283345 0.15675172898354567 1.2188532196473056 0.06393487417565268 0.99999823131742 0.0002496961101595441 0.07521226061298085 0.004822980667718131 0.009875349739036015 0.025118879410405952 1.0631489051327722e-07 6.9734059037283345 -1.154918345471653 VISHMLSSHGGEIFLHVLSSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VISHMLSSHGGEIFLHVLSSSR 22 0 Q9NVM9;Q9NVM9-2;H0YH12 Q9NVM9 ASUN Protein asunder homolog 0 33201000.0 10339000.0 11100000.0 11762000.0 False True 15685018.882146398 9119118.275304168 9437235.544532273 1.0 0.5813903281738526 0.6016719275533856 23.90288393015828 -10.188720930680008 4.770003121331208 1.0000551255922296 0.5915311278618455 0.9981543656978817 0.008279928280619813 4.854682234981173e-06 8.256666384767385e-07 0.00801808500639608 0.002672335360693458 6.475585908391482e-11 10.188720930680008 -0.40852399773038417 VISHMLSSHGGEIFLHVLSSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VISHMLSSHGGEIFLHVLSSSR 22 0 Q9NVM9;Q9NVM9-2;H0YH12 Q9NVM9 ASUN Protein asunder homolog 0 32474000.0 10339000.0 11492000.0 10643000.0 False True 13384039.312158663 10852460.097720105 8706083.206401955 1.0 0.8108508832502638 0.6504824891311368 23.674010252250728 -6.973037731589446 0.1706778523701196 1.1404020889394946 0.3166338430661946 0.9999974142978997 0.00022963367448402218 0.07532875244402897 0.0053277188881534375 0.0067164244216409204 0.018538143375479335 1.0640505692870162e-07 6.973037731589446 -0.8237682458733 VISMQKGGNMK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VISMQKGGNMK 11 1 P12277;H0YJG0 P12277 CKB Creatine kinase B-type 1 1951470.0 328570.0 776510.0 846390.0 True False 273220.5131190235 772326.7865048327 1023366.235734802 1.0 2.8267525658601724 3.745568822971177 18.05970627821163 -8.97266465784281 0.25616653173980686 2.3806008068542837e-16 4.34998270053871 0.9991045258615191 0.034147419142118676 0.4482524026824446 0.08611579181321194 0.7803937216785009 0.3732691232243986 1.0649650176693068e-09 8.97266465784281 4.34998270053871 VISMQKGGNMK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VISMQKGGNMK 11 1 P12277;H0YJG0 P12277 CKB Creatine kinase B-type 1 6515600.0 773100.0 1821900.0 3920600.0 True False 1000793.1900792981 1720509.6634211878 3207091.028753128 1.0 1.7191460538264283 3.2045492121094603 19.932712447121748 -6.959409504694452 0.44367684053053397 0.9488790975279414 4.033084940992042 0.9997476698086586 0.014581490228064039 0.07991272526351668 0.021915759393273525 0.01967724169224155 0.12299271345900165 1.0979700539082368e-07 6.959409504694452 3.0842058434641006 VISSIEQK(ub)TDTSDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VISSIEQKTDTSDK 14 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 11088200.0 3612800.0 5343200.0 2132200.0 True False 4736415.78640497 4546015.387630475 1911580.3975066256 1.0 0.959800742299482 0.40359218525397905 22.1753643028786 -6.921442798105539 0.8139583060028514 1.011646010279723 0.3108540503757098 0.9945722851796364 0.020051551290703542 0.09733041878847971 0.10127111764596426 0.017409736129924296 0.05289164070074509 1.198276940523937e-07 6.921442798105539 -0.7007919599040131 down VISSIEQK(ub)TDTSDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VISSIEQKTDTSDK 14 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 17455600.0 5632200.0 5914800.0 5908600.0 True False 5453408.893910406 8276610.485274529 4360960.405799523 1.0 1.5176948302036684 0.7996760357854745 22.37872690139986 -6.713265552878705 1.783663334191164 1.3172071713558968 0.8012047584353329 0.4805081135108089 0.21804677209227996 0.3685723769138109 2.2877519130666855 0.09721198186495736 0.2459819910829756 1.9352382849738388e-07 6.713265552878705 -0.5160024129205639 VISSIEQK(ub)TDTSDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VISSIEQKTDTSDK 14 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 26875800.0 8603900.0 10201000.0 8070900.0 True False 13052745.329345139 8380551.849223216 6475683.077398862 1.0 0.6420528124747893 0.49611655739886784 23.637849938936714 -13.999999999999998 0.12343261571584327 2.7026383200004047 0.273612778694523 0.999676278357538 0.0038088171658875775 11.951858970746612 0.1085521859965932 4.970547264723181 0.19752642300080922 1.0000000000000041e-14 13.999999999999998 -2.4290255413058817 VISSIEQK(ub)TDTSDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VISSIEQKTDTSDK 14 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 11429100.0 3612800.0 5215200.0 2601100.0 True False 4948549.792248952 4984775.219639848 1986773.7513360532 1.0 1.0073204128303683 0.401486058490912 22.23857436440149 -6.904167407256429 0.9345638120697646 1.0223900050064632 0.3322299399237635 0.98852752892311 0.030406637366660584 0.10840188384834115 0.16063209583699795 0.02419762990160017 0.06438076249753248 1.2469027786622802e-07 6.904167407256429 -0.6901600650826997 down VISSIEQK(ub)TDTSDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VISSIEQKTDTSDKK 15 2 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 12485200.0 6499100.0 4030600.0 1955500.0 True False 8520383.037373932 3429250.191155744 1753163.618480538 1.0 0.4024760595989207 0.2057611272627575 23.022486858190586 -13.999999999984903 0.1553022034168107 3.915410855710047 0.0019946399839776323 0.9995495181134669 0.007168143524037434 11.981648497461634 0.12436077004502509 10.52830685550763 0.18468178299627835 1.0000000000347627e-14 13.999999999984903 -3.9134162157260692 VISSIEQK(ub)TDTSDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VISSIEQKTDTSDKK 15 2 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 12280100.0 3548900.0 5192000.0 3539200.0 True False 3436242.1120696478 7265192.675922309 2612177.346275884 1.0 2.1142842788648806 0.7601843121300235 21.712400259344378 -6.688069963945106 1.8731347074747706 1.6998417300721695 0.7649548617992012 0.36145609927889655 0.471449795810707 0.42083859090304376 2.8612402046930763 0.20145621243200607 0.5259127492446035 2.050831767445018e-07 6.688069963945106 -0.9348868682729683 VISSIEQK(ub)TDTSDKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VISSIEQKTDTSDKK 15 2 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 34107200.0 14167700.0 9447700.0 10491800.0 True False 21493436.69760957 7761684.119782982 8418091.131280696 1.0 0.3611188024038153 0.3916586839840708 24.357392845450406 -9.985813173820462 5.10219022662771 1.0000038558452116 0.37638874318866145 0.9982044906021945 0.01246785446623034 17161171.891238753 5.388746385091451 841.1158522420874 0.004268078206205025 1.0332057779168218e-10 9.985813173820462 -0.6236151126565501 VISSIEQK(ub)TDTSDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VISSIEQKTDTSDKK 15 2 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 11554700.0 6499100.0 2772600.0 2283000.0 True False 8901992.901573617 2650097.3642378915 1743802.4198609097 1.0 0.2976970880048029 0.19588899240221316 23.085696919713477 -13.999999999999998 0.27200218481753224 6.479376311940162 0.16274554451648549 0.9995876489444229 0.007259333135194832 14.982104551498365 0.16511582362139918 45.44931933796488 0.04186410291475608 1.0000000000000041e-14 13.999999999999998 -6.316630767423677 VISSIEQK(ub)TDTSDKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VISSIEQKTDTSDKK 15 2 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 18606600.0 3548900.0 11687400.0 3370300.0 True False 2951067.592927238 11624437.65643275 4075014.1474934737 1.0 3.9390618108147697 1.3808610000191033 21.492805534778654 -6.612587343368093 2.143921316316161 2.960213975142817 1.3901742950714642 0.058443525429281884 1.2663041534044333 0.6056757775600909 5.279107333953488 0.4870840358816087 1.405467593041232 2.4401282709817753e-07 6.612587343368093 -1.570039680071353 VISSIEQK(ub)TDTSDKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VISSIEQKTDTSDKK 15 2 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 40618100.0 14167700.0 16794200.0 9656200.0 True False 18340366.93711869 15859588.006711714 7898870.6809789175 1.0 0.8647366795379552 0.4306822599602714 24.128519167542855 -6.949928647773058 0.5596356179212952 1.0056877149021608 0.26900038178984703 0.9991956071079661 0.006887905823520136 0.0835145861463389 0.036082393003733525 0.007386694311047955 0.03607876029806878 1.1222028109900416e-07 6.949928647773058 -0.7366873331123138 down VISSIEQK(ub)TER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VISSIEQKTER 11 1 P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 19072660.0 7828400.0 7151560.0 4092700.0 True False 10263108.21033343 6084575.124562539 3669226.6639505546 1.0 0.592858907834205 0.35751612364918717 23.290964385462495 -9.178715243012203 0.1580732264663107 1.514836238113246 9.038619366852444e-22 0.9997906410315262 0.003840136121403849 0.6219888462998063 0.05517755134121998 0.32132629344579827 0.17027585587468352 6.626508463402634e-10 9.178715243012203 -1.514836238113246 VISSIEQK(ub)TER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VISSIEQKTER 11 1 P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 29029490.0 10899560.0 9131830.0 8998100.0 True False 10553559.433917494 12778217.34086433 6641227.672786231 1.0 1.2107969278873942 0.6292879397108772 23.33122632774917 -6.808635923266348 1.4203194306779492 1.1150678100992901 0.619434041313494 0.8562265789674857 0.09114360114131242 0.20866313058452823 0.8298951688840466 0.05046270336435502 0.11680117775945084 1.5536889490461023e-07 6.808635923266348 -0.4956337687857961 VISSIEQK(ub)TER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VISSIEQKTER 11 1 P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 44939800.0 22107800.0 10924000.0 11908000.0 True False 33539148.8966743 8974526.85039843 9554378.580538178 1.0 0.26758361931147073 0.2848724220752536 24.999342743151757 -9.870930166789915 6.73923150079671 1.0000000178048545 0.2762280208416246 0.9995722381511178 0.007058124172554034 1.8879395323814246e-09 3.173247815750832e-10 0.006833999547577665 0.0022779997813030493 1.3460767816401816e-10 9.870930166789915 -0.7237719969632299 VISSIEQK(ub)TER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VISSIEQKTER 11 1 P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 20016100.0 7828400.0 8029700.0 4158000.0 True False 10722771.034555368 7674921.303332965 3175966.0366980527 1.0 0.7157591333993465 0.2961889260213741 23.354174446985386 -7.057910322273167 0.3669340399127324 1.0356425535891323 6.687105735550437e-14 0.9999025380259327 0.0028540195468545835 0.07342371317446181 0.01581865110519146 0.005925264222086411 0.034029383121459464 8.751644698047536e-08 7.057910322273167 -1.0356425535890654 down VISSIEQK(ub)TER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VISSIEQKTER 11 1 P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 33427260.0 10899560.0 18165500.0 4362200.0 True False 9063467.072379036 18067638.845930554 5274315.85146605 1.0 1.9934577686051047 0.5819313745332132 23.111631603183447 -6.717580587578177 1.7682334450114838 1.6059638461013612 0.5844537682106323 0.5010192121683487 0.418178389999534 0.36001917218401036 2.198603234014531 0.18788657080498009 0.47297520629302164 1.9161054776799938e-07 6.717580587578177 -1.021510077890729 VISSIEQK(ub)TER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VISSIEQKTER 11 1 P31946;Q4VY19;A0A0J9YWE8;Q4VY20;A0A0J9YWZ2;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 55125600.0 22107800.0 24843100.0 8174700.0 True False 28618982.909888852 23460559.646159995 6686988.479505226 1.0 0.8197551855713767 0.2336556998045741 24.770469065244207 -6.949626898077189 0.5629254348275098 1.007551243049059 0.017708018667358504 0.999171673295958 0.009415789820004227 0.0836359264179601 0.03658516613836231 0.01005789673784586 0.04875231649310022 1.1229827933225911e-07 6.949626898077189 -0.9898432243817005 down VISSIEQK(ub)TMADGNEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VISSIEQKTMADGNEK 16 1 Q04917;A2IDB2 Q04917 YWHAH 14-3-3 protein eta 1 5397850.0 2067600.0 2355900.0 974350.0 True False 1719301.0102105876 2343208.299090462 1178082.0801146084 1.0 1.3628842681849267 0.6852099039773796 20.71339071909701 -6.761237413936605 1.6076206850742898 1.2104623358890776 0.6825669228383384 0.6960309057208465 0.15265970062114073 0.2808652765852446 1.430881399085238 0.07491088587560213 0.1798171505024972 1.7328564454405677e-07 6.761237413936605 -0.5278954130507392 VISSIEQK(ub)TMADGNEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VISSIEQKTMADGNEK 16 1 Q04917;A2IDB2 Q04917 YWHAH 14-3-3 protein eta 1 12512400.0 3407800.0 4465400.0 4639200.0 True False 4411464.27778066 4216896.56459793 3794913.202211779 1.0 0.955894981590871 0.8602389055547202 22.072826171967836 -6.958430219932789 0.4570311559211307 1.0028724187371036 0.8094246020810273 0.9997074293643355 0.0009978142841017494 0.08026689449408074 0.02324092338803882 0.0012926913553760028 0.007904838937435682 1.1004486451743958e-07 6.958430219932789 -0.19344781665607635 VISSIEQK(ub)TSADGNEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VISSIEQKTSADGNEK 16 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 21282300.0 6634400.0 9404700.0 5243200.0 True False 8697762.647620995 8001555.419233467 4700683.960325831 1.0 0.9199555958706285 0.5404474864132511 23.052212909101975 -6.940997345464971 0.6502180564146037 1.0041973945148388 0.4350316982482161 0.9982916470226 0.00828504518055856 0.087314550142885 0.052559488811431944 0.008127174675741434 0.03252264111046111 1.1455199431774237e-07 6.940997345464971 -0.5691656962666227 VISSIEQK(ub)TSADGNEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VISSIEQKTSADGNEK 16 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 34838900.0 12041000.0 13077000.0 9720900.0 True False 11658765.04591018 18298714.295654085 7174704.669251019 1.0 1.5695242355083874 0.6153914793718105 23.474911643444713 -6.745036421290495 1.6681694789726433 1.3368816492071627 0.6141905156012888 0.6273035475864226 0.23928343948155362 0.30881278343285234 1.6891404626027007 0.1133886548673771 0.27673173999345363 1.7987200625259325e-07 6.745036421290495 -0.7226911336058739 VISSIEQK(ub)TSADGNEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VISSIEQKTSADGNEK 16 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 59174000.0 23245000.0 20864000.0 15065000.0 True False 35264364.43713052 17140656.188823953 12087396.146775937 1.0 0.4860616790466307 0.34276517781358024 25.07170770274221 -13.999999999999993 0.1791801768297712 3.6599422402248125 0.2279687006327036 0.9994991494826336 0.006315072355015053 12.194232858355672 0.13418031588315163 11.29038187298291 0.10774040121233058 1.0000000000000164e-14 13.999999999999993 -3.431973539592109 VISSIEQK(ub)TSADGNEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VISSIEQKTSADGNEK 16 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 22006900.0 6634400.0 11271000.0 4101500.0 True False 9087316.967918634 10773009.951787233 3132810.173044024 1.0 1.1854995253075993 0.3447453394774195 23.115422970624866 -6.8488471787427745 1.2406031890997888 1.0989015280336578 0.3118681842536796 0.938617239915397 0.08935378474288612 0.1587286041001014 0.4706878664569397 0.05637492770082222 0.13036552333357002 1.416292062726744e-07 6.8488471787427745 -0.7870333437799781 down VISSIEQK(ub)TSADGNEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VISSIEQKTSADGNEK 16 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 35804500.0 12041000.0 19670000.0 4093500.0 True False 10012625.006744873 19564033.805810712 4949431.923794476 1.0 1.9539365343885005 0.4943191141644031 23.25531691887899 -6.730339135889851 1.7217964611599486 1.5738458055333107 0.4950999128474907 0.5609425298744012 0.40100115238727607 0.3355938298356412 1.9492110616659484 0.1845425515204565 0.4577885758630205 1.8606336204370352e-07 6.730339135889851 -1.07874589268582 VISSIEQK(ub)TSADGNEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VISSIEQKTSADGNEK 16 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 66151000.0 23245000.0 28850000.0 14056000.0 True False 30091110.727452133 27244472.138811775 11497952.22673927 1.0 0.9053993515087042 0.3821046132487786 24.84283402483466 -6.937579181032996 0.6817160393186544 1.0061922298198822 0.25050312486890447 0.9978292668300036 0.01266065004032139 0.08888870306987305 0.05977109998028174 0.012108847549925753 0.04554015514541323 1.1545714627986236e-07 6.937579181032996 -0.7556891049509777 down VITEYLNAQESAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VITEYLNAQESAK 13 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 25814600.0 2988600.0 11077000.0 11749000.0 False True 3918083.541643571 9424354.777807808 10533326.184366075 1.0 2.4053480936893057 2.6883873384556574 21.90171672849934 -10.3168635509094 0.35077623063565305 1.663938602652422e-15 2.7425461759257868 0.9990406136556322 0.02286803902835751 1.7553069459190573 0.16379728658735138 1.7252261754305278 0.08363678174692545 4.8209924249297556e-11 10.3168635509094 2.742546175925785 VITEYLNAQESAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VITEYLNAQESAK 13 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 29559600.0 2988600.0 13305000.0 13266000.0 False True 4093566.1838782155 12717141.106248682 10132844.021846157 1.0 3.1066167090037258 2.475309685171957 21.964926790022233 -10.048228334924763 5.231450991899205 0.9999812094372076 2.790963197091874 0.9147540914619903 0.2577300132512355 5.648536422432512e-05 1.0275567481406536e-05 0.24954861694113017 0.0831820040929585 8.948941417671992e-11 10.048228334924763 1.7909819876546664 VITEYLNAQESAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VITEYLNAQESAK 13 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 11910900.0 4930500.0 3743400.0 3237000.0 False True 4099929.2081849985 3723233.5611932785 3913841.7338030403 1.0 0.9081214265261718 0.9546120274441672 21.967167568839734 -10.220787162181601 4.69336347182139 1.0000151149032983 0.9313667269848611 0.7439758026481167 0.018979708348467562 3.002454569221884e-06 4.984651468087265e-07 0.01838107034430905 0.006125674528974256 6.014684312234071e-11 10.220787162181601 -0.06864838791843719 VITEYLNAQESAK(ub)SAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VITEYLNAQESAKSAR 16 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 83329600.0 19518000.0 40140600.0 23671000.0 True False 25588287.01258086 34151778.94683327 21221751.988265328 1.0 1.3346645256105671 0.8293541485536464 24.608980234755247 -6.72812217249265 1.7299323629793457 1.2018219055606616 0.8297502946447267 0.5505515701790373 0.14070767282577346 0.3397957787582233 1.9912874952460795 0.06447727256566348 0.16034607407990745 1.8701559679962105e-07 6.72812217249265 -0.3720716109159349 VITEYLNAQESAK(ub)SAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VITEYLNAQESAKSAR 16 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 96908300.0 31483300.0 30576000.0 34849000.0 True False 30483879.874587156 42785156.251733616 25721001.452409633 1.0 1.403533816159714 0.8437574730719205 24.861543199575518 -6.713285745963427 1.7834134369959167 1.247252253868984 0.8449389528126992 0.48064814137150835 0.16996338407662656 0.3685511007453991 2.286952877634956 0.07578206481741216 0.19176458703705973 1.9351483056538463e-07 6.713285745963427 -0.40231330105628493 VITEYLNAQESAK(ub)SAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VITEYLNAQESAKSAR 16 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 486304100.0 45607900.0 67060200.0 373636000.0 True False 69190518.68411295 55092783.36626597 299786680.8295236 1.0 0.7962475844095095 4.332771115623369 26.04407102021552 -6.893236155080504 1.0030088104699149 0.8244570390245822 4.656993044049052 0.9828911881164875 0.2120597269037068 0.11655799523314529 0.20680855958875385 0.16036565544853604 0.4047581837508728 1.278685807720168e-07 6.893236155080504 3.83253600502447 up VITEYLNAQESAK(ub)SAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VITEYLNAQESAKSAR 16 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 56729700.0 19518000.0 19725400.0 17486300.0 True False 26734332.054117296 18853866.604825117 13356396.081652982 1.0 0.7052305090944464 0.49959714926171095 24.67219029627814 -7.884968387015582 0.13177754053552945 1.388435665109767 7.188916700538002e-11 0.9999762875752267 0.0010000219159288502 0.12167753976817455 0.019553493710552098 0.08379380686628601 0.10656316112157166 1.3032616414823666e-08 7.884968387015582 -1.3884356650378777 down VITEYLNAQESAK(ub)SAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VITEYLNAQESAKSAR 16 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 104042200.0 31483300.0 48175900.0 24383000.0 True False 26179758.89667393 47916366.86453261 29481372.565745912 1.0 1.8302829698947405 1.1261132190751935 24.641948475009794 -10.231074587442942 4.520975909492991 0.999843768757487 1.4781980944873496 0.3807640025429685 0.287476096991427 202705147.21022487 95.28773055974148 336995.6813808527 0.09841071441259273 5.873884634608385e-11 10.231074587442942 0.4783543257298626 VITEYLNAQESAK(ub)SAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VITEYLNAQESAKSAR 16 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 422723800.0 45607900.0 72948900.0 304167000.0 True False 59040325.616113774 68889229.58776315 248811727.01697478 1.0 1.166816559171573 4.21426752682182 25.815197342307968 -6.9181986735967484 0.8379835425556825 0.9282958979191431 4.685888061044571 0.9936656335364703 0.11759009276417216 0.09924323220446848 0.1111936467051576 0.10036114990189657 0.2956397330781648 1.207261431494416e-07 6.9181986735967484 3.7575921631254277 up VITLCLYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VITLCLYR 8 0 Q10570 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 0 37007800.0 10545000.0 8720800.0 17742000.0 False True 15997535.942763655 7164505.104078609 14235285.923405139 1.0 0.4478505395900929 0.8898424091270347 23.931346372016936 -9.974853427374423 6.94216382639329 1.0000000253101042 0.6688464743585683 0.4280683236186864 0.18044242513738587 7.073058343261138e-08 1.0500443544252337e-08 0.17471263989366884 0.058237542292197464 1.059611279344966e-10 9.974853427374423 -0.331153550951536 VITLCLYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VITLCLYR 8 0 Q10570 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 0 28142900.0 10545000.0 9752400.0 7845500.0 False True 13650710.37302571 9209670.366951423 6417699.501627975 1.0 0.6746660148288004 0.47013666880733024 23.702472694109385 -8.854462141680829 0.124211614907798 1.5410760879362404 2.8336931357556e-17 0.999930945499852 0.001813060403631227 0.36167809492883446 0.03710199881592893 0.25045277362898544 0.1813941305903431 1.3980987850800953e-09 8.854462141680829 -1.5410760879362404 VITMFVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VITMFVQR 8 0 P13010;C9JZ81;H7C0H9 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 14273100.0 3778800.0 4950600.0 5543700.0 False True 4954043.393951256 4211989.777287663 4970091.102925377 1.0 0.8502125319351019 1.0032393153830093 22.240175074962163 -11.035354577219927 9.228998640055794 1.1553236898692147 0.9267259236581986 0.23413104530953688 0.06247292273779193 0.05369205051423586 0.00020568442639415594 0.016266805710400574 0.02016304911269758 9.218185064453824e-12 11.035354577219927 -0.22859776621101613 VITMFVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VITMFVQR 8 0 P13010;C9JZ81;H7C0H9 P13010 XRCC5 X-ray repair cross-complementing protein 5 0 12697200.0 3778800.0 3969100.0 4949300.0 False True 5175924.478230274 3793732.037941506 3780377.2740331055 1.0 0.7329573787055409 0.7303772089282247 22.303385136485055 VITVDGNICTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VITVDGNICTGK 12 0 Q8N1B9;C9J6X0;A0A087WXC5;E7ESZ7;O95299;O95299-2 Q8N1B9 NDUFA10 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 0 4807300.0 1423400.0 1911600.0 1472300.0 False True 1866091.184225208 1626396.7313584383 1319960.5192988496 1.0 0.8715526578266916 0.7073397754927452 20.831588052735402 -6.967776975988595 0.30667551991976827 1.0263123689978468 0.547385227194783 0.999959478317818 0.0007624260033215847 0.07703086609987024 0.011598814890977452 0.0026381613586823455 0.014626722769957627 1.0770181546741632e-07 6.967776975988595 -0.47892714180306384 VITVDGNICTGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VITVDGNICTGK 12 0 Q8N1B9;C9J6X0;A0A087WXC5;E7ESZ7;O95299;O95299-2 Q8N1B9 NDUFA10 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 0 6991500.0 1132900.0 5858600.0 0.0 False True 1718692.1260841142 4813087.056549277 0.0 1.0 2.8004358567205774 0.0 20.712879703464285 -6.733079015513113 1.7118277732733929 2.0797548441162257 0.0006532964713172373 0.5735439782548712 0.7566959570535219 0.33050307530036965 1.8986839684201373 0.3500894037094717 0.8657696296759619 1.8489321937571945e-07 6.733079015513113 -2.0791015476449086 VITVDGNICTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VITVDGNICTGK 12 0 Q8N1B9;C9J6X0;A0A087WXC5;E7ESZ7;O95299;O95299-2 Q8N1B9 NDUFA10 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 0 4956800.0 1423400.0 1715100.0 1818300.0 False True 1949669.4459386498 1639321.2109227448 1388854.9890639894 1.0 0.840820075596717 0.7123540823584781 20.894798114258293 -6.973559934206487 0.15054497596276195 1.148202855199699 0.40159094506652787 0.9999985189459764 0.0001430666412737944 0.07516353104263339 0.004603960774522791 0.006520776198852162 0.0159904516485484 1.0627719067947917e-07 6.973559934206487 -0.7466119101331712 VIVGGSSEYK(ub)INNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIVGGSSEYKINNK 14 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 16057800.0 5192800.0 5454400.0 5410600.0 True False 6807811.087146735 4640624.781084675 4850763.014140023 1.0 0.6816618031376128 0.7125290276192222 22.698759572943526 -9.979000758102828 5.861705860628664 1.0000003136956184 0.697095415661883 0.9922718508839274 0.01260149162629172 5.166199737907641e-08 8.99502918674045e-09 0.012201354346325423 0.004067113933787999 1.0495405965765726e-10 9.979000758102828 -0.3029048980337353 VIVGGSSEYK(ub)INNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIVGGSSEYKINNK 14 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 23618100.0 5324400.0 5938700.0 12355000.0 True False 5155379.836429211 8310053.879911367 9118854.857944876 1.0 1.6119188388778718 1.768803686104514 22.29764729525801 -11.30020164807632 0.24768697437356835 1.9345386761885975e-17 1.8441309413372649 0.9992809546091858 0.00889405855524733 3.5479274008169015 0.1363589395747202 2.0161585763207537 0.07289202484045795 5.009545804693326e-12 11.30020164807632 1.8441309413372649 VIVGGSSEYK(ub)INNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIVGGSSEYKINNK 14 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 66102000.0 18739000.0 18176000.0 29187000.0 True False 28428433.00440476 14932350.790263828 23418176.656883467 1.0 0.5252611281089667 0.8237589688202303 24.760831243034264 -10.497254418432407 6.058511573766495 1.0002928516404048 0.6745100484645995 0.613208649986196 0.12186123317752792 0.00048246326892694894 4.0035741201118e-05 0.11809581253082507 0.039330543887072 3.182332701125887e-11 10.497254418432407 -0.3257828031758053 VIVGGSSEYK(ub)INNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIVGGSSEYKINNK 14 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 15022700.0 5192800.0 3742200.0 6087700.0 True False 7112718.490143477 3576857.230199464 4649910.640117061 1.0 0.5028818777456371 0.6537459125594135 22.761969634466418 -10.8277765301333 10.794622662962391 1.0058331335496096 0.578313895152534 0.9124119076380066 0.06158998430520493 0.008585302440219156 0.00013697443262161878 0.059214719486129226 0.01987808195893624 1.4867004396791055e-11 10.8277765301333 -0.4275192383970756 VIVGGSSEYK(ub)INNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIVGGSSEYKINNK 14 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 22133200.0 5324400.0 11184000.0 5624800.0 True False 4427474.510913743 11123749.572149808 6800919.6738632405 1.0 2.5124367276942463 1.5360720106008394 22.078052570692286 -10.527839953031696 5.224075714619575 0.9965020951710818 2.02425436914755 0.5947049385160108 0.39859922662264274 0.016265300591612433 0.0014700807291482536 0.38657034512028193 0.12864734721005047 2.965924195765252e-11 10.527839953031696 1.0277522739764682 VIVGGSSEYK(ub)INNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIVGGSSEYKINNK 14 1 Q14683;G8JLG1;H0Y7K8 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 53429000.0 18739000.0 18435000.0 16255000.0 True False 24258004.900913116 17409076.044332597 13296756.790384654 1.0 0.7176631431745357 0.5481389275292026 24.531957565126714 -10.265841336977909 0.08849317555802085 1.860788465614816 9.97716051609888e-12 0.9999488585786357 0.0013328371229546958 2.0180789333417315 0.044902399989838665 0.6790179118399087 0.3033545176015005 5.4219893853102e-11 10.265841336977909 -1.8607884656048388 VIVGSLSVQDLQASQSACYWLK(ub)GVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIVGSLSVQDLQASQSACYWLKGVR 25 1 Q15043-2;Q15043-3;Q15043;E5RFT1 Q15043-2 SLC39A14 Zinc transporter ZIP14 1 20829400.0 2945600.0 8334800.0 9549000.0 True False 4468690.5522052795 6847389.819910364 7661635.964524613 1.0 1.532303420860325 1.7145147722846077 22.091420713798428 -11.341173522356197 0.19634840038511517 7.338871798708201e-14 1.858684451593972 0.9993988699544126 0.007432525355295952 3.7558496264851104 0.1148390020633579 1.7450340507334727 0.11739813732823988 4.558547428018416e-12 11.341173522356197 1.8586844515938985 VIVLSSSHSYQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIVLSSSHSYQR 12 0 K7ENR6;Q969U7-2;Q969U7;V9GZ55 K7ENR6 PSMG2 Proteasome assembly chaperone 2 0 32083100.0 13309500.0 10178300.0 8595300.0 False True 17448883.38938133 8659737.31470266 7705940.80793955 1.0 0.49629177532200247 0.44162945192407366 24.056631380867362 -13.999999999999998 0.313631835492973 5.973866783788736 0.42998922136404744 0.999679949127047 0.004496228756448521 17.532517304423404 0.17833078857156634 57.02308756154301 0.018665015961056016 1.0000000000000041e-14 13.999999999999998 -5.543877562424689 VIVLSSSHSYQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIVLSSSHSYQR 12 0 K7ENR6;Q969U7-2;Q969U7;V9GZ55 K7ENR6 PSMG2 Proteasome assembly chaperone 2 0 18493200.0 7146900.0 3022300.0 8324000.0 False True 6920025.571515278 4229120.151086287 6143694.68535274 1.0 0.6111422721462916 0.8878138703189005 22.722345938375497 -10.08839288556152 5.911465794591973 1.0000010230844212 0.749478071232583 0.5222633965327312 0.11295070697391861 1.522985746511371e-06 2.3487817428750007e-07 0.10936449826729083 0.03645468392102165 8.158439821693092e-11 10.08839288556152 -0.25052295185183815 VIVLSSSHSYQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIVLSSSHSYQR 12 0 K7ENR6;Q969U7-2;Q969U7;V9GZ55 K7ENR6 PSMG2 Proteasome assembly chaperone 2 0 25545500.0 8141200.0 8891700.0 8512600.0 False True 12350795.601444067 7304906.663830811 6830080.878794875 1.0 0.5914523160740118 0.5530073607562815 23.558100643129816 -13.999999999999998 0.334314594654528 5.5647595506202805 0.5465379475403296 0.999723725712201 0.0033619039636810163 19.19425733848693 0.18513292075878246 61.74279624977511 0.012124764341864998 1.0000000000000041e-14 13.999999999999998 -5.018221603079951 VIVLSSSHSYQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIVLSSSHSYQR 12 0 K7ENR6;Q969U7-2;Q969U7;V9GZ55 K7ENR6 PSMG2 Proteasome assembly chaperone 2 0 35020700.0 13309500.0 7970500.0 13740700.0 False True 18230381.825713392 7618336.95508118 10495429.658599539 1.0 0.417892341911114 0.5757109071514924 24.119841442390253 -10.572382900070009 9.741047528679275 1.0000343795933824 0.49680162453146975 0.9312953071650305 0.06442915946284412 4.8108353330714954e-05 2.1118553888617396e-06 0.06238749053289244 0.02079442180081144 2.6768072502771243e-11 10.572382900070009 -0.5032327550619127 VIVLSSSHSYQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIVLSSSHSYQR 12 0 K7ENR6;Q969U7-2;Q969U7;V9GZ55 K7ENR6 PSMG2 Proteasome assembly chaperone 2 0 20535200.0 7146900.0 6776000.0 6612300.0 False True 5942964.011353286 6739496.343069314 7994901.35817912 1.0 1.134029472531611 1.3452717100264895 22.502751213809773 -6.964422232023734 0.367839892195417 0.9833522464247283 1.5032769987592272 0.9999007254748508 0.0014160893925282442 0.07815764789617095 0.015555051208583087 0.0027938143208670134 0.017961732100392654 1.0853698865775835e-07 6.964422232023734 0.5199247523344989 VIVLSSSHSYQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIVLSSSHSYQR 12 0 K7ENR6;Q969U7-2;Q969U7;V9GZ55 K7ENR6 PSMG2 Proteasome assembly chaperone 2 0 26848800.0 8141200.0 11739200.0 6968400.0 False True 10538943.887043823 11085903.20041386 5700222.7018219875 1.0 1.0518988732867673 0.540872288809662 23.329226965222265 -6.881879671513236 1.0692983959077833 1.0330371363702762 0.5033305501221944 0.9751686936199652 0.036187672760358475 0.12597635909490837 0.2623555884968275 0.026024670424797093 0.06324384536184745 1.3125635161280994e-07 6.881879671513236 -0.5297065862480818 VIVQLVTNGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIVQLVTNGK 10 0 P19838;P19838-2;A0A494C1E9;D6RC45;D6RH30;A0A494C157 P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit;Nuclear factor NF-kappa-B p50 subunit 0 9738200.0 3656600.0 2934100.0 3147500.0 False True 4793838.010564776 2496343.71703222 2821826.892951928 1.0 0.520740106680851 0.5886362632056231 22.192749728769428 -10.545794002548224 6.3170161873479165 1.000601779764096 0.5546881849433203 0.9828637207124835 0.02771848983030507 0.000235219885799179 1.6912762903453467e-05 0.02687251380965277 0.008946104124565942 2.8458106312214695e-11 10.545794002548224 -0.44591359482077575 VIVQLVTNGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIVQLVTNGK 10 0 P19838;P19838-2;A0A494C1E9;D6RC45;D6RH30;A0A494C157 P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit;Nuclear factor NF-kappa-B p50 subunit 0 8776100.0 4077400.0 1430300.0 3268400.0 False True 3947965.168855916 2001426.2489159629 2412307.990101745 1.0 0.5069513441264625 0.6110256516778768 21.912677830916735 -10.452960158645972 7.49581599466558 1.0000349896762413 0.5589884979022169 0.9599061933053845 0.042488158139075215 2.484638233360826e-05 1.8132179148759511e-06 0.04114223100609781 0.01371299407363878 3.524031983622659e-11 10.452960158645972 -0.44104649177402433 VIVQLVTNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIVQLVTNGK 10 0 P19838;P19838-2;A0A494C1E9;D6RC45;D6RH30;A0A494C157 P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit;Nuclear factor NF-kappa-B p50 subunit 0 11443200.0 3656600.0 2927700.0 4858900.0 False True 5008543.835899449 2798344.5333907744 3711327.8921866636 1.0 0.5587141942001671 0.7409993830113244 22.25595979029232 -10.1868394822775 5.378987577260119 1.0000148001251388 0.6498567886056754 0.8310688902363761 0.07441761670928415 1.3208781249367766e-05 1.996661867662809e-06 0.07205759123577522 0.024018182514923023 6.503700264041801e-11 10.1868394822775 -0.35015801151946335 VIVQLVTNGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIVQLVTNGK 10 0 P19838;P19838-2;A0A494C1E9;D6RC45;D6RH30;A0A494C157 P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit;Nuclear factor NF-kappa-B p50 subunit 0 7716600.0 4077400.0 1989100.0 1650100.0 False True 3390538.7594470116 1978384.3234945606 1995128.280799626 1.0 0.5835014621148971 0.5884398977126061 21.69308310635101 -9.906622507368786 5.433166649720762 1.0000004748199445 0.5859706799118704 0.9998933072071277 0.0020161078977259436 2753031.41995991 0.8330635935510686 16.352845246041095 0.000690167357582215 1.239873827661266e-10 9.906622507368786 -0.4140297949080741 VIVSVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIVSVQR 7 0 Q92956-2;Q92956 Q92956-2 TNFRSF14 Tumor necrosis factor receptor superfamily member 14 0 43990000.0 14902000.0 10088000.0 19000000.0 False True 19536666.31117328 8582909.722716011 17034062.260869466 1.0 0.43932314684656976 0.8719021960838559 24.2196809745754 -9.876541789952208 6.531074613740454 1.0000000158364475 0.6556126714652 0.45802052466246646 0.17659965734168329 4.063228956224842e-08 7.217432358845805e-09 0.17099188932746867 0.056997294319178146 1.3287956877145787e-10 9.876541789952208 -0.3443873443712475 VIVSVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIVSVQR 7 0 Q92956-2;Q92956 Q92956-2 TNFRSF14 Tumor necrosis factor receptor superfamily member 14 0 29362500.0 7512900.0 3269600.0 18580000.0 False True 7274407.101853535 4575168.330738749 13713340.61194788 1.0 0.6289403750269883 1.8851489090366815 22.794398235754294 -6.827585326805501 1.338605223827056 0.8013711341205705 1.9173287283137086 0.900965750438743 0.165834500970063 0.18381301216714346 0.6449931356160507 0.09729205563770855 0.2239373303497201 1.4873551213926076e-07 6.827585326805501 1.1159575941931381 VIVSVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIVSVQR 7 0 Q92956-2;Q92956 Q92956-2 TNFRSF14 Tumor necrosis factor receptor superfamily member 14 0 18072800.0 5458400.0 6126900.0 6487500.0 False True 8280791.862492287 5033506.825311806 5205242.781427736 1.0 0.6078533199356204 0.6285923940444391 22.981337303409447 -10.111022315949224 5.1348698460392335 1.00001039980557 0.6182228569893892 0.9977916890417502 0.008466691552982412 1.008040830926764e-06 1.7453117913172122e-07 0.008198062024583263 0.0027326129481908814 7.744220035917943e-11 10.111022315949224 -0.3817875428161809 VIVSVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIVSVQR 7 0 Q92956-2;Q92956 Q92956-2 TNFRSF14 Tumor necrosis factor receptor superfamily member 14 0 35941300.0 14902000.0 8128300.0 12911000.0 False True 20411672.111407727 7769164.829306373 9861687.710391656 1.0 0.38062363469792965 0.48313962994144566 24.28289103609829 -10.064150006952058 5.318413563659768 1.000005986891105 0.431881632319945 0.9761609842455549 0.04185197980580677 2.971037485144938e-06 5.227380537305561e-07 0.04052343188975033 0.013507668399122636 8.626805231940833e-11 10.064150006952058 -0.5681243545711601 VIVSVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VIVSVQR 7 0 Q92956-2;Q92956 Q92956-2 TNFRSF14 Tumor necrosis factor receptor superfamily member 14 0 23979000.0 7512900.0 8361200.0 8104900.0 False True 6247309.22790245 8316156.556031745 9799597.117176462 1.0 1.331158143875634 1.5686108626428121 22.57480351118857 -6.974726087035974 0.09057596591804287 0.31131973575708116 2.594440034598153 0.9999998310970459 9.565892591242369e-05 0.07479668293731223 0.0026431048531650072 0.02439067660019101 0.04188475197168413 1.0599220156039396e-07 6.974726087035974 2.2831202988410717 VIVSVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIVSVQR 7 0 Q92956-2;Q92956 Q92956-2 TNFRSF14 Tumor necrosis factor receptor superfamily member 14 0 13637100.0 5458400.0 5815000.0 2363700.0 False True 7066006.401149698 5491390.138204179 1933530.8536100998 1.0 0.7771561227726435 0.2736384237205755 22.752463625501896 -6.957590779428325 0.46815466633067165 1.0135405790042575 0.016676262029232326 0.9996701409618838 0.005518086326825339 0.08057325348513814 0.024398371807545144 0.006938056208770018 0.04156382476342456 1.1025777408481061e-07 6.957590779428325 -0.9968643169750252 down VIVVGNPANTNCLTASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIVVGNPANTNCLTASK 17 0 P40925;P40925-3;A0A5K1VW95;P40925-2;B9A041;C9JF79;C9JRL4 P40925 MDH1 Malate dehydrogenase, cytoplasmic;Malate dehydrogenase 0 29053400.0 2924000.0 17206000.0 8923400.0 False True 3833392.316056278 14638931.868462697 8000092.167296975 1.0 3.81879303277859 2.086948453929004 21.870190222945396 -10.131935107742551 6.102031116350124 0.9999901437230686 2.952870743353819 0.6289952554131367 0.7070225886645304 9.480501381344453e-05 1.3487606636822857e-05 0.6845751225553962 0.2281905592741705 7.380144959760787e-11 10.131935107742551 1.9528805996307503 VIVVGNPANTNCLTASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VIVVGNPANTNCLTASK 17 0 P40925;P40925-3;A0A5K1VW95;P40925-2;B9A041;C9JF79;C9JRL4 P40925 MDH1 Malate dehydrogenase, cytoplasmic;Malate dehydrogenase 0 8848600.0 4892100.0 1477500.0 2479000.0 False True 4736802.963300153 2067473.4550607135 1829675.5315941193 1.0 0.43647022497644594 0.38626802629750423 22.175482230734314 -13.999999999999998 0.3422939417289387 7.6097744665262965 0.37860778046436766 0.9997397562571134 0.00448856955204037 19.916269663215484 0.18781678098468843 95.36103759045838 0.015384803937081562 1.0000000000000041e-14 13.999999999999998 -7.231166686061929 VIVVGNPANTNCLTASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIVVGNPANTNCLTASK 17 0 P40925;P40925-3;A0A5K1VW95;P40925-2;B9A041;C9JF79;C9JRL4 P40925 MDH1 Malate dehydrogenase, cytoplasmic;Malate dehydrogenase 0 25216000.0 2924000.0 11201000.0 11091000.0 False True 4005081.818128854 10706102.783246271 8471534.226315072 1.0 2.673129606188192 2.1151962958581736 21.933400284468288 -10.441716913739228 7.798009359547783 0.9999382244237109 2.3941629510231826 0.892765138821532 0.22777532013507396 0.0002446399925723457 1.7514184030207596e-05 0.2205520066710911 0.07351416846335036 3.616455172992048e-11 10.441716913739228 1.3942247265994716 VIWGPFGGGIFGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VIWGPFGGGIFGQK 14 0 D6RCP5;Q8N264-3;Q8N264;D6RHH1;Q8N264-4 D6RCP5 ARHGAP24 Rho GTPase-activating protein 24 0 2113700.0 753240.0 523340.0 837120.0 False True 987504.934386537 445259.7119633421 750502.8526220552 1.0 0.4508936578022759 0.7599990911319209 19.913428431522473 -10.184390901993655 5.579162123425586 1.0000111094012085 0.6054463744670774 0.6847801151492536 0.12619176473002386 1.7438222605343668e-05 2.5494967239869357e-06 0.12218808761839249 0.040728216935643706 6.540472108970926e-11 10.184390901993655 -0.39456473493413113 VIWGPFGGGIFGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIWGPFGGGIFGQK 14 0 D6RCP5;Q8N264-3;Q8N264;D6RHH1;Q8N264-4 D6RCP5 ARHGAP24 Rho GTPase-activating protein 24 0 3309640.0 753240.0 818200.0 1738200.0 False True 1031733.183545616 782049.2185744214 1327672.9593527073 1.0 0.7579956049168255 1.2868375085020292 19.976638493045364 -6.782266646903718 1.5268376002177597 0.8633737203989874 1.2913429853510172 0.7753822725610791 0.10244525244717535 0.24707517980794735 1.137785284708181 0.05283652787922684 0.1244484712374955 1.6509478426780693e-07 6.782266646903718 0.4279692649520298 VIYVLPMLTIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VIYVLPMLTIK 11 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 23505000.0 6061100.0 7758100.0 9685800.0 False True 9195131.825764326 6373606.440688037 7771397.384563059 1.0 0.6931500887055793 0.8451643251908547 23.132438827268963 -10.179410779934734 4.810354091309142 1.0000260610048712 0.7691572069473188 0.7545832023881704 0.06205955217437732 1.7347116738465037e-05 2.959253929594205e-06 0.0600956819964839 0.02002963433659791 6.615904385415384e-11 10.179410779934734 -0.23086885405755242 VIYVLPMLTIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VIYVLPMLTIK 11 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 114098000.0 14510000.0 34207000.0 65381000.0 False True 19874739.11800606 32695621.632577915 49939354.363962345 1.0 1.6450843172555873 2.5127048997950583 24.24443258746996 -6.967006614793433 0.3217571438236863 0.8836031237701802 3.3022433273618015 0.9999487343710839 0.0044376416334199 0.07728647318909927 0.012493003854677257 0.013059098575253348 0.07620029867341478 1.0789302887828528e-07 6.967006614793433 2.4186402035916212 VIYVLPMLTIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VIYVLPMLTIK 11 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 21758100.0 6061100.0 9457700.0 6239300.0 False True 7846213.432142831 8931370.681013528 5103811.4206242375 1.0 1.1383033049324451 0.6504808293534231 22.903565149361413 -6.830982831303054 1.3236993967942674 1.0738485725759628 0.6371057253344935 0.9077909146211374 0.06233549228145013 0.1796031476623919 0.6151476027704252 0.036972707076853455 0.08507455636832136 1.4757648726288207e-07 6.830982831303054 -0.4367428472414693 VK(ub)ACTTEEDQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKACTTEEDQEK 12 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 16217800.0 4352600.0 5317000.0 6548200.0 True False 5706300.750638356 4523724.325503674 5870655.078769767 1.0 0.7927595342740411 1.028802254790553 22.444124355504265 -6.674827801219445 1.920385588522949 0.8682704258722672 1.0278680815000172 0.30053439944364 0.08793487026922142 0.45013569941878123 3.2048778893514123 0.03680516025596389 0.09771477211994992 2.114327209354473e-07 6.674827801219445 0.15959765562774997 VK(ub)ACTTEEDQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKACTTEEDQEK 12 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 8551800.0 3810000.0 2686300.0 2055500.0 True False 3689053.6354885614 3758953.598869436 1517102.8863217896 1.0 1.0189479390346725 0.41124446435999606 21.814819333984676 -6.899701948244987 0.9631380024258025 1.0254731322561663 0.34783773564658244 0.986417795637596 0.032878350146733064 0.11162542502606533 0.17865449189264856 0.025616735941083407 0.06655216209678932 1.2597896956614185e-07 6.899701948244987 -0.6776353966095838 down VK(ub)ACTTEEDQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKACTTEEDQEK 12 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 17790400.0 4352600.0 5710900.0 7726900.0 True False 5961873.844592218 5458573.554579159 5901965.360500758 1.0 0.9155801844969291 0.9899514002387351 22.507334417027156 -10.077728585139246 4.796057371548617 1.000001782337795 0.9527657923672247 0.34973160137221404 0.030361921688402103 5.786497850371744e-07 1.1130353013549345e-07 0.02939891324646833 0.009799268087872511 8.361253964089788e-11 10.077728585139246 -0.047235989970570214 VK(ub)ACTTEEDQEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKACTTEEDQEK 12 1 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 1 16505900.0 4387900.0 3124700.0 8993300.0 True False 5680223.048439977 2950807.6981679476 7356611.679050516 1.0 0.5194879977430396 1.2951272540381922 22.43751615126543 -6.739115324699977 1.6897432648748942 0.7138120123047533 1.295513540047179 0.6010749119297828 0.20189512034754145 0.31940494733260216 1.790292978853676 0.09453236387102325 0.2322168023295758 1.8234114403533816e-07 6.739115324699977 0.5817015277424256 VK(ub)ADRDESSPYAAMLAAQDVAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKADRDESSPYAAMLAAQDVAQR 23 2 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 1 11851800.0 2881500.0 4728500.0 4241800.0 True False 2396094.9220941216 4703026.631966237 5128740.76813276 1.0 1.9627881135259533 2.140458093225447 21.19225363142495 -10.784732383033402 0.32989591208545066 8.702059217788499e-14 2.179942714832721 0.999229554703883 0.013906706305055012 2.4722752034796516 0.16305871764718988 2.007462123336663 0.05670309657167052 1.641601033941281e-11 10.784732383033402 2.179942714832634 VK(ub)ADRDESSPYAAMLAAQDVAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKADRDESSPYAAMLAAQDVAQR 23 2 P62263;A0A2R8Y811;E5RH77 P62263 RPS14 40S ribosomal protein S14 1 49119800.0 7416500.0 8170300.0 33533000.0 True False 9600805.451071149 7715615.622729094 27430338.07763573 1.0 0.8036425341655343 2.857087170178557 23.194724013858107 -6.883446238557094 1.0603491417069792 0.8717180320614506 3.0126097500790734 0.9763623398678197 0.14224535911042074 0.12462311082621415 0.2541876885813208 0.10299353751466635 0.25140479672216304 1.3078374264834271e-07 6.883446238557094 2.140891718017623 up VK(ub)AFHYESNNDLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKAFHYESNNDLEK 14 1 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 1 12934600.0 2596600.0 3596200.0 6741800.0 True False 3939232.036887638 2954430.012761153 5409280.2749640895 1.0 0.7500015193558969 1.3731814283369628 21.909482969420985 -6.797810719066498 1.4647156727159882 0.8616815500171822 1.381339029172971 0.8257334829181757 0.10689434152513282 0.22388757578386023 0.9484759871321171 0.05741788416549871 0.13372190625349806 1.5929028193115854e-07 6.797810719066498 0.5196574791557889 VK(ub)AFHYESNNDLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKAFHYESNNDLEK 14 1 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 1 5041700.0 2006400.0 1386100.0 1649200.0 True False 2748220.3009212487 1324857.5187802557 1259692.9263401714 1.0 0.4820783538845636 0.4583667931999125 21.390066226430527 VK(ub)AFHYESNNDLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKAFHYESNNDLEK 14 1 K7ES98;K7EM85;Q92619;Q92619-2;F5H1R4 K7ES98 HMHA1 Minor histocompatibility protein HA-1;Minor histocompatibility antigen HA-1 1 13773100.0 2596600.0 4542500.0 6634000.0 True False 3361349.886638083 4289705.881821586 5426680.070588233 1.0 1.2761854690801069 1.6144347519906144 21.680609291513434 -6.968407447816938 0.29374722667901126 0.9368016735503304 1.9643239954160707 0.9999671571076811 0.0014399738785528043 0.07682293577675389 0.010870222956065287 0.005793209466773886 0.03054339648654603 1.0754557655739379e-07 6.968407447816938 1.0275223218657403 VK(ub)AFLADPSAFVAAAPVAAATTAAPAAAAAPAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKAFLADPSAFVAAAPVAAATTAAPAAAAAPAK 33 1 P05388;F8VWS0;P05388-2;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 1 7630700.0 1847900.0 2556600.0 3226200.0 True False 2422614.795089055 2175165.2455487484 2892383.7718956326 1.0 0.8978584833041069 1.1939098934584478 21.208133598383245 -6.813557166578242 1.399637282985121 0.9445642705969949 1.1995163131672044 0.8688946211381362 0.04445775339608446 0.20198463541263684 0.7791729977634425 0.024971924082821544 0.05767481951500784 1.5361825709114456e-07 6.813557166578242 0.25495204257020954 VK(ub)AFLADPSAFVAAAPVAAATTAAPAAAAAPAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKAFLADPSAFVAAAPVAAATTAAPAAAAAPAK 33 1 P05388;F8VWS0;P05388-2;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 1 13971600.0 3547500.0 4331800.0 6092300.0 True False 3434886.554303325 6061510.330038572 4496543.864917655 1.0 1.7646901096178962 1.3090807494891659 21.711831020551905 -10.261953268193125 4.5151549015450225 0.9997507266573961 1.5368854295567622 0.6493037013748288 0.18600174240550846 0.0004678173292564396 7.64690978515364e-05 0.18017794132761675 0.0600318042232588 5.47074827145747e-11 10.261953268193125 0.5371347028993662 VK(ub)AFLADPSAFVAAAPVAAATTAAPAAAAAPAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKAFLADPSAFVAAAPVAAATTAAPAAAAAPAK 33 1 P05388;F8VWS0;P05388-2;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 1 42596200.0 9129200.0 0.0 33467000.0 True False 13849663.833919214 0.0 26852232.78089282 1.0 0.0 1.9388364297427214 23.72334762308358 -6.766504213738357 1.587742447698253 0.4238755878636354 1.9483581501585556 0.7170650276953968 0.42109577489815303 0.2721082791515999 1.3532005155226237 0.20911543010398792 0.49941369475949365 1.7119685662624547e-07 6.766504213738357 1.5244825622949203 VK(ub)AFLADPSAFVAAAPVAAATTAAPAAAAAPAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKAFLADPSAFVAAAPVAAATTAAPAAAAAPAK 33 1 P05388;F8VWS0;P05388-2;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 1 9924900.0 1847900.0 3027400.0 5049600.0 True False 2531118.5676198048 2893639.457726967 3856988.479776452 1.0 1.1432255662555022 1.5238276583002823 21.271343659906137 -6.954140832305346 0.5113705542084214 0.9930735308827485 1.6907162742615633 0.999487438840889 0.005004521821910032 0.08186442118903112 0.029401851629353108 0.005750685779371239 0.03141494580216143 1.1113712751792033e-07 6.954140832305346 0.6976427433788148 VK(ub)AFLADPSAFVAAAPVAAATTAAPAAAAAPAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKAFLADPSAFVAAAPVAAATTAAPAAAAAPAK 33 1 P05388;F8VWS0;P05388-2;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 1 15014500.0 3547500.0 5484500.0 5982500.0 True False 2949903.4308967204 5454953.90991199 7233413.090045312 1.0 1.849197452627721 2.4520847070056386 21.49223629598618 -7.77071921487237 0.13988102068824232 1.0097157245770666e-19 3.832792253293026 0.9999757768061314 0.0029315945230624645 0.13443440173066773 0.018717965060518944 0.1975165876852151 0.27429112345217854 1.6954335976553958e-08 7.77071921487237 3.832792253293026 VK(ub)AFLADPSAFVAAAPVAAATTAAPAAAAAPAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKAFLADPSAFVAAAPVAAATTAAPAAAAAPAK 33 1 P05388;F8VWS0;P05388-2;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 1 48079100.0 9129200.0 4833900.0 34116000.0 True False 11817929.363435414 4564889.215660396 27907238.059720863 1.0 0.3862681079973392 2.3614321258397135 23.49447394517603 -6.8232412899128425 1.3578694526532495 0.6702494986878543 2.4075981231307226 0.8916657462661891 0.27167068901255076 0.18929901277126673 0.6849367205335284 0.1571879806358785 0.3620040606653634 1.5023070665613558e-07 6.8232412899128425 1.7373486244428684 up VK(ub)ALFAISCLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKALFAISCLVR 12 1 Q9NZL4;Q9NZL4-3;K7EN20 Q9NZL4 HSPBP1 Hsp70-binding protein 1 1 24988400.0 5342100.0 10640000.0 9006300.0 True False 8104356.2598234005 8741208.869300554 7226200.857398473 1.0 1.0785815170335356 0.8916440276967706 22.950266164364436 -6.792496853487164 1.4861959072675648 1.0437768003334031 0.8895126431711913 0.8093604577315723 0.033462299476444766 0.23164643209570665 1.0106946449106624 0.017719268999852447 0.04141360255600513 1.6125127101331062e-07 6.792496853487164 -0.15426415716221187 VK(ub)ALFAISCLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKALFAISCLVR 12 1 Q9NZL4;Q9NZL4-3;K7EN20 Q9NZL4 HSPBP1 Hsp70-binding protein 1 1 2958910.0 537210.0 1122600.0 1299100.0 True False 735831.0545543779 1072999.8200582312 992279.3358043394 1.0 1.4582149168847516 1.3485151648094922 19.48901503863324 -10.060039661826986 4.945360040356505 0.999990937371439 1.4033650408502107 0.9474431633222901 0.04478473625972471 6043198.694072502 12293304.900912698 382.5340238204403 0.015331006552083849 8.708840530719108e-11 10.060039661826986 0.4033741034787718 VK(ub)ALFAISCLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKALFAISCLVR 12 1 Q9NZL4;Q9NZL4-3;K7EN20 Q9NZL4 HSPBP1 Hsp70-binding protein 1 1 19349800.0 5342100.0 5941100.0 8066600.0 True False 6915453.758533967 5610472.56235338 6598561.5703055505 1.0 0.8112949284679716 0.9541762262762067 22.721392486456885 -10.375753491137566 5.430468967329857 1.000047776340506 0.8827355774000266 0.4731549585777054 0.05833104556947611 3.375443161832656e-05 3.880148823444753e-06 0.056501782975843885 0.01882626400478637 4.209655038170181e-11 10.375753491137566 -0.1173121989404794 VK(ub)AMEVDERPTEQYSDIGGLDK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VKAMEVDERPTEQYSDIGGLDK 22 2 E9PMD8;P17980;R4GNH3;E9PM69;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 103985900.0 39623600.0 34798900.0 29563400.0 True False 51946923.31548825 29607039.76504981 26504462.96015729 1.0 0.5699478982660425 0.5102219971563714 25.63053496870326 -13.999999999999998 0.27813350622760946 4.469107419019905 0.49190870573918377 0.9996010544463237 0.0043576978548151134 15.298264673631987 0.16703858443218028 30.154574344839503 0.023837384295941042 1.0000000000000041e-14 13.999999999999998 -3.977198713280721 VK(ub)AMEVDERPTEQYSDIGGLDK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VKAMEVDERPTEQYSDIGGLDK 22 2 E9PMD8;P17980;R4GNH3;E9PM69;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 98797600.0 34054400.0 34975600.0 29767600.0 True False 32973361.71243608 48941539.4753445 21970572.551142033 1.0 1.4842750915775123 0.6663127873569444 24.974797644899585 -6.746307152479407 1.6636126524347563 1.2860197851776658 0.665144171544641 0.6328848156522952 0.20346905129429452 0.30653205236129033 1.6679680044539316 0.0966671128179477 0.23558950776108697 1.7934647597031793e-07 6.746307152479407 -0.6208756136330248 VK(ub)AMEVDERPTEQYSDIGGLDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKAMEVDERPTEQYSDIGGLDK 22 2 E9PMD8;P17980;R4GNH3;E9PM69;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 36254800.0 20063400.0 6885500.0 9305900.0 True False 30437644.631014198 5656728.728342956 7466584.78607914 1.0 0.1858464673241857 0.24530757476782952 24.859353386698547 -10.25950285030942 8.196140793528839 1.0000006688541272 0.21557702104601859 0.9957089943111157 0.024274895462955675 2.966759322684049e-07 2.6793040591414213e-08 0.02350408677476515 0.007834688821579444 5.5017030968711964e-11 10.25950285030942 -0.7844236478081086 VK(ub)AMEVDERPTEQYSDIGGLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKAMEVDERPTEQYSDIGGLDK 22 2 E9PMD8;P17980;R4GNH3;E9PM69;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 11546100.0 3170500.0 4738600.0 3637000.0 True False 4342719.529540883 4529232.98354529 2778015.506366235 1.0 1.0429485378311145 0.6396948933655704 22.05016735002143 -6.8805555810487276 1.0766625472001572 1.0268213750653261 0.6108065042923663 0.9741322377016917 0.029082849362810137 0.1271405970049092 0.2693037108630353 0.020796991063389406 0.050365583856877276 1.3165714070064011e-07 6.8805555810487276 -0.41601487077295984 VK(ub)AMEVDERPTEQYSDIGGLDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKAMEVDERPTEQYSDIGGLDK 22 2 E9PMD8;P17980;R4GNH3;E9PM69;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 45030800.0 20063400.0 15526500.0 9440900.0 True False 25972466.8087401 14662436.62610957 7722753.07181437 1.0 0.5645376980971039 0.29734384218042603 24.630479708790997 -8.616461318852442 0.20168928515481183 1.3299437422419076 7.29359043106688e-09 0.9996693136122559 0.005266073937942383 0.21409957063381171 0.05483190953756996 0.1713135387706101 0.1291480467127677 2.4184587323161817e-09 8.616461318852442 -1.3299437349483172 down VK(ub)CLGNPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKCLGNPER 9 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 16754610.0 3708300.0 6234510.0 6811800.0 True False 4861617.211228278 5304345.409929637 6106980.279399515 1.0 1.091066034092286 1.2561623044477823 22.21300487379669 -6.961918952548925 0.4074880055391411 0.9916410346323578 1.3616892058070356 0.9998348788393728 0.0013623847857447185 0.07902262583072267 0.01864996668322374 0.002124711984715113 0.013795723377489794 1.0916440385805326e-07 6.961918952548925 0.3700481711746778 VK(ub)CLGNPER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKCLGNPER 9 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 14408480.0 3847140.0 4330240.0 6231100.0 True False 3725014.646517969 6059327.413903284 4598987.981006904 1.0 1.6266586816154829 1.2346227914314103 21.82881466749422 -10.134000470463468 4.213364135673284 0.9999047453224625 1.4306407365701566 0.6166902947550661 0.16004798214964241 74521510.45804964 71233054.1573618 82124.58386815408 0.058571558923309994 7.345130724717709e-11 10.134000470463468 0.430735991247694 VK(ub)CLGNPER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKCLGNPER 9 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 108271670.0 6400970.0 13065700.0 88805000.0 True False 9710739.463589558 10734023.752219949 71252652.8253857 1.0 1.1053765567974712 7.337510504997864 23.211149729009204 -6.910571298545233 0.8918418454151769 0.8105101096445142 8.152811264640826 0.9911352321357589 0.2789755895482507 0.104041276149554 0.13672945432934497 0.2290482104782744 0.634802236528751 1.2286514611212507e-07 6.910571298545233 7.342301154996312 up VK(ub)CLGNPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKCLGNPER 9 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 19050180.0 3708300.0 4698080.0 10643800.0 True False 5079358.7230394045 4490503.291127006 8129953.655941981 1.0 0.8840689417659328 1.6005866289902735 22.276214935319583 -6.865422969444713 1.1579612168725786 0.9359328897852162 1.639067618914687 0.9599017098287711 0.06288341290700228 0.14132298138473987 0.35704240725636893 0.04225035865658014 0.09931333604459351 1.3632547844596556e-07 6.865422969444713 0.703134729129471 VK(ub)CLGNPER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKCLGNPER 9 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 16182840.0 3847140.0 3376800.0 8958900.0 True False 3199067.367199439 3358608.5081576826 10832164.568726601 1.0 1.0498711413814055 3.3860382809660576 21.609219942928497 -6.911508452110967 0.8853907805689661 0.9310724111035364 3.6979058247733207 0.9914786556641868 0.1027626572122039 0.10342922769514787 0.1334158884540232 0.08476567744003488 0.23651367821692754 1.2260030423365511e-07 6.911508452110967 2.7668334136697843 up VK(ub)CLGNPER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKCLGNPER 9 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 89363570.0 6400970.0 9362600.0 73600000.0 True False 8286181.846982114 8841563.079613153 60205555.199773006 1.0 1.0670249872482962 7.265777690082953 22.982276051101653 -6.909264007580249 0.9007392805043101 0.8035785688738877 8.054359359450672 0.9906406873061837 0.28423691604792817 0.10490653192200755 0.14142475811510194 0.23186506919897615 0.6368295880523593 1.2323554566970617e-07 6.909264007580249 7.250780790576784 up VK(ub)CNTDDTIGDLKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKCNTDDTIGDLKK 14 2 Q9BZL1 Q9BZL1 UBL5 Ubiquitin-like protein 5 1 6060830.0 3060400.0 908230.0 2092200.0 True False 4191912.584200259 868101.3954850241 1598065.4502115594 1.0 0.20708957499662226 0.38122585290419203 21.999177201358 -10.465312744593977 9.046214367673658 1.000010275717137 0.294157714101436 0.9563445160313162 0.07109083776350551 1.4733329407998231e-05 8.707025216368768e-07 0.06883440662871161 0.022944469227165858 3.4252104110547704e-11 10.465312744593977 -0.705852561615701 VK(ub)DASPNQVAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKDASPNQVAEK 12 1 O43402-2;O43402 O43402-2 EMC8 ER membrane protein complex subunit 8 1 3598080.0 738280.0 1486300.0 1373500.0 True False 967892.2295136891 1264549.8335520225 1231383.3955423285 1.0 1.3064985904343782 1.272231926235247 19.88448689321578 -10.100394588152172 4.439307599266679 0.9999714243676904 1.2893652583520172 0.9895919735510326 0.013989307142596195 9738147.146496542 0.2815487693746954 2923.0078125463883 0.004788911919166358 7.936068574597762e-11 10.100394588152172 0.28939383398432683 VK(ub)DASPNQVAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKDASPNQVAEK 12 1 O43402-2;O43402 O43402-2 EMC8 ER membrane protein complex subunit 8 1 3203780.0 738280.0 1198500.0 1267000.0 True False 1011242.0672668153 1145546.3070904978 967760.6946840878 1.0 1.132811167742141 0.9570020136719104 19.94769695473867 -6.704651445443329 1.814346248961123 1.0820917102110315 0.9574778571241545 0.4396614853169889 0.0560149734012077 0.3859168354315 2.472905026067545 0.024601045588871093 0.06290515970132504 1.9740063917201746e-07 6.704651445443329 -0.124613853086877 VK(ub)DEYSERDENVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKDEYSERDENVLK 14 2 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-14;A0A0C4DGN9 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 23530800.0 1872300.0 3395500.0 18263000.0 True False 2423729.258550597 3206537.4401156143 14939321.394204555 1.0 1.322976742886349 6.163774828191144 21.208797121616332 -6.920435212615707 0.8214976115651017 0.8948578330952753 6.952252284335243 0.9943008683429748 0.17829719482139744 0.09791630691878464 0.10429390651495592 0.15397631823050922 0.4631651248596652 1.201060231973134e-07 6.920435212615707 6.057394451239968 up VK(ub)DLESLFHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKDLESLFHR 10 1 Q03252 Q03252 LMNB2 Lamin-B2 1 17908000.0 6960100.0 6615700.0 4332200.0 True False 9124758.50170428 5628663.347796624 3883945.5013967785 1.0 0.6168561443840216 0.4256491282121443 23.121354945957165 -12.907789949486645 0.10054763984647803 2.5546969833409134 2.751171284488093e-18 0.9998258938103743 0.0031509726550218078 8.196592975680096 0.08330916252714404 2.9197046680889263 0.3468092876180797 1.2365453553512694e-13 12.907789949486645 -2.5546969833409134 VK(ub)DLESLFHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKDLESLFHR 10 1 Q03252 Q03252 LMNB2 Lamin-B2 1 27360600.0 11182000.0 7993300.0 8185300.0 True False 10827033.53071735 11185066.374508822 6041324.376263558 1.0 1.0330684155337377 0.5579851913383044 23.368134681233254 -6.890209322680027 1.0211626073286906 1.025398909133104 0.5169585537535107 0.9810312446351361 0.029829381400453676 0.11897272672490958 0.2208663231139639 0.022251631807456783 0.05551464791878129 1.2876287865565552e-07 6.890209322680027 -0.5084403553795932 VK(ub)DLESLFHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKDLESLFHR 10 1 Q03252 Q03252 LMNB2 Lamin-B2 1 25027900.0 11182000.0 10809000.0 3036900.0 True False 9298328.446592571 10750769.771581488 3671901.7489609015 1.0 1.156204562285727 0.3948991230038225 23.14853995666753 -6.8532268621248615 1.219315564364579 1.0836521792856846 0.36249996455814243 0.944879323215159 0.07708176193305485 0.15394735042260835 0.4388032608943982 0.04942111447711393 0.1146320114791191 1.4020811090427044e-07 6.8532268621248615 -0.7211522147275422 down VK(ub)EALLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKEALLR 7 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 62196000.0 26735000.0 22311000.0 13150000.0 True False 36619651.98620896 21325226.247389276 10044240.832751177 1.0 0.5823437714651248 0.2742855348962317 25.126114744801832 -8.00021234910267 0.25023550444664255 1.1768097891506075 1.4606192475754054e-13 0.9996090062101181 0.00588057072981641 0.10106122705055717 0.04574033556314357 0.06758537695566874 0.09583522322050662 9.995111676391713e-09 8.00021234910267 -1.1768097891504614 down VK(ub)EDPDGEHAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKEDPDGEHAR 11 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 39018000.0 14468000.0 13221000.0 11329000.0 True False 18967688.108311303 11248478.335054364 10156783.755441597 1.0 0.5930337039929227 0.5354782141842092 24.177040509648734 -13.999999999999998 0.2755347044687256 4.236574769630308 0.5173752963635407 0.9995953436410481 0.004159018925556173 15.161870553596764 0.16622266107413383 27.57924883835728 0.023260937650685924 1.0000000000000041e-14 13.999999999999998 -3.7191994732667673 VK(ub)EDPDGEHAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKEDPDGEHAR 11 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 14245700.0 6900000.0 0.0 7345700.0 True False 6680963.276869052 0.0 5421640.80372365 1.0 0.0 0.8115058531296752 22.671624698156887 -9.733124437730487 10.49101163561313 0.9999999993542991 0.4057529265648374 0.4169003765586292 0.3312958772416086 0.0 0.0 0.3207758561959481 0.10692528460199388 1.848738826786489e-10 9.733124437730487 -0.5942470727894617 VK(ub)EFCENLSADCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKEFCENLSADCR 13 1 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 19726400.0 7125600.0 6343600.0 6257200.0 True False 9341730.604408566 5397159.6071591275 5609764.967300649 1.0 0.5777472971241635 0.6005059667052782 23.15525841081341 -10.329883438276356 5.710204833316392 1.000061263973693 0.589126631914721 0.9977041634133931 0.009291187949730346 7.247602397746429e-06 8.505326210817317e-07 0.00899748946109526 0.002998718016314512 4.678606951074903e-11 10.329883438276356 -0.41093463205897196 VK(ub)EFCENLSADCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKEFCENLSADCR 13 1 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 21308500.0 7125600.0 5036000.0 9146900.0 True False 9760126.882099519 4813492.868175003 6986590.606318765 1.0 0.4931793332526394 0.7158298955244593 23.2184684723363 -10.31109678177601 5.755672719834074 1.0000428587954557 0.6045046143885479 0.8079513613307955 0.09089671141829642 4.9995783565544736e-05 5.98384557610945e-06 0.08801987117686637 0.029336787462339104 4.8854347614028635e-11 10.31109678177601 -0.3955382444069079 VK(ub)EFCENLSADCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKEFCENLSADCR 13 1 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 67630000.0 18578000.0 15715000.0 33337000.0 True False 24049587.227128662 14840446.435404768 27270008.066505857 1.0 0.6170769708123844 1.1339075306766373 24.51950879685613 -6.708277136097243 1.8015433228248692 0.7641725541860246 1.1326228106632297 0.4568451724618712 0.1614057739282719 0.37853873269109606 2.3938456563913397 0.07132970001804498 0.18157717441261848 1.9575950757841676e-07 6.708277136097243 0.3684502564772051 VK(ub)EPSQDTVATEPSEVEGSAANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKEPSQDTVATEPSEVEGSAANK 23 1 Q96RU2-2;Q96RU2;F5GZ74;Q96RU2-3 Q96RU2-2 USP28 Ubiquitin carboxyl-terminal hydrolase 28 1 9253100.0 4278100.0 2932100.0 2042900.0 True False 4142294.057213545 4102902.8206995046 1507803.2043136864 1.0 0.9904904779887747 0.3640019717306022 21.981998541961634 -6.9102014907641625 0.8943543008947444 1.01927427372136 0.2826870427537709 0.9909974522834241 0.0282364546851336 0.10428540781530178 0.13804331075746923 0.02314055454083112 0.06396852588085829 1.2296981204581871e-07 6.9102014907641625 -0.7365872309675892 down VK(ub)EPSQDTVATEPSEVEGSAANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKEPSQDTVATEPSEVEGSAANK 23 1 Q96RU2-2;Q96RU2;F5GZ74;Q96RU2-3 Q96RU2-2 USP28 Ubiquitin carboxyl-terminal hydrolase 28 1 10438200.0 6356000.0 2499700.0 1582500.0 True False 8705984.964441512 2389254.9885975104 1208746.0926105499 1.0 0.27443821673895813 0.13884082014241003 23.05357609786437 -13.999999999999998 0.23586351017614798 5.708067577463911 0.07648570135608122 0.9995183381036563 0.008297389214892946 13.481005334014379 0.15373466441145606 29.82286780749854 0.0679075809686112 1.0000000000000041e-14 13.999999999999998 -5.63158187610783 VK(ub)EPSQDTVATEPSEVEGSAANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKEPSQDTVATEPSEVEGSAANK 23 1 Q96RU2-2;Q96RU2;F5GZ74;Q96RU2-3 Q96RU2-2 USP28 Ubiquitin carboxyl-terminal hydrolase 28 1 11778380.0 4278100.0 6556800.0 943480.0 True False 3557429.701964554 6521477.2169771 1140757.3058413619 1.0 1.8331991812447288 0.3206689664763833 21.76240381739591 -6.757141334881236 1.6230731141085364 1.4856826884169907 0.3158813613030108 0.6792445219892924 0.3503186477845117 0.2877503494719973 1.4933164693444798 0.17034635028475814 0.41055871781211534 1.7492773188856027e-07 6.757141334881236 -1.16980132711398 VK(ub)EPSQDTVATEPSEVEGSAANK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKEPSQDTVATEPSEVEGSAANK 23 1 Q96RU2-2;Q96RU2;F5GZ74;Q96RU2-3 Q96RU2-2 USP28 Ubiquitin carboxyl-terminal hydrolase 28 1 22053600.0 9515000.0 6116200.0 6422400.0 True False 12317355.068690361 5775828.093428109 5253589.09938889 1.0 0.4689178854728121 0.42651925434406396 23.55418916058972 -13.999999999999998 0.35831447569304853 7.876278362166079 0.42129036319653834 0.9997702251080833 0.0039551479187469865 21.5160504265964 0.19332035967911002 113.04980795672044 0.012302503623555276 1.0000000000000041e-14 13.999999999999998 -7.45498799896954 VK(ub)ETTYYDVLGVKPNATQEELKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKETTYYDVLGVKPNATQEELKK 23 3 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 25708100.0 8998800.0 3532300.0 13177000.0 True False 11797513.944503166 3005294.6087975567 11813570.44270931 1.0 0.25473965302645973 1.0013610069275336 23.491979540933478 -10.91840699032966 12.179672324680233 1.0377318462357303 0.6280503299769975 0.2486328386640847 0.3048068913539283 0.16234644947313334 0.0010875752965602992 0.15342023277625555 0.09837600116858482 1.206682486882156e-11 10.91840699032966 -0.40968151625873284 VK(ub)ETTYYDVLGVKPNATQEELKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKETTYYDVLGVKPNATQEELKK 23 3 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 40289600.0 3139400.0 9759200.0 27391000.0 True False 3039741.4654206806 13656099.453555685 20216475.3876138 1.0 4.492520041228496 6.650721983297343 21.53551719482969 -8.354706145031479 0.3067083861225551 2.2169507479411335e-18 7.804406584280829 0.998716238504639 0.08341984372678522 0.12323640272725038 0.07999246139605563 0.6772019504342819 0.6628814745411499 4.418693265330616e-09 8.354706145031479 7.804406584280829 VK(ub)ETTYYDVLGVKPNATQEELKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKETTYYDVLGVKPNATQEELKK 23 3 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 96907000.0 10805000.0 27226000.0 58876000.0 True False 16391974.951309768 22367307.58229107 47239132.79373249 1.0 1.3645279259351146 2.8818451061601906 23.966486349082754 -6.943960943508672 0.6216214538617705 0.9834104839296085 3.3435713771196043 0.9986380464389423 0.03007338882128755 0.08600516390004768 0.0467232993092999 0.030241542207263432 0.12849002164116818 1.1377295982635552e-07 6.943960943508672 2.360160893189996 up VK(ub)ETTYYDVLGVKPNATQEELKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKETTYYDVLGVKPNATQEELKK 23 3 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 22261500.0 8998800.0 6781100.0 6481600.0 True False 12325899.543426113 6481488.579901011 4950779.572742206 1.0 0.5258430475654691 0.40165665437234976 23.55518960245637 -13.999999999999998 0.1880797819715571 3.525134366333057 0.3108221203505417 0.9994905791904044 0.005819189791979949 12.320113532772107 0.13752627789775418 11.394019702617902 0.08672727111329324 1.0000000000000041e-14 13.999999999999998 -3.2143122459825157 VK(ub)ETTYYDVLGVKPNATQEELKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKETTYYDVLGVKPNATQEELKK 23 3 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 27075700.0 3139400.0 8839000.0 15097300.0 True False 2610550.199001316 8791382.55259586 18254075.627971772 1.0 3.367635893751081 6.9924246754400645 21.315922470263967 -6.9649153116940665 0.35950281210940216 0.685872575826151 9.79830936617745 0.9999113891371822 0.023197061819981084 0.07798971912601901 0.01496135157467038 0.04868129383486148 0.3096950188120346 1.0841383025805985e-07 6.9649153116940665 9.1124367903513 VK(ub)ETTYYDVLGVKPNATQEELKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKETTYYDVLGVKPNATQEELKK 23 3 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 207681000.0 10805000.0 83853000.0 113023000.0 True False 13987285.498391937 79186506.83728898 92453973.7139124 1.0 5.661320550466546 6.609858197613931 23.737612671175203 -9.468066017255193 0.48243010106130485 3.6979729669642517e-19 6.6226542339966645 0.9982715273848002 0.10192979968602375 0.7994388811789588 0.2045190795029312 1.6784901766780722 0.1978375987823007 3.403564480664601e-10 9.468066017255193 6.6226542339966645 VK(ub)GDVDVSLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKGDVDVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 13448900.0 4307600.0 4290500.0 4850800.0 True False 6534944.12774289 3524826.7531704954 3892037.253818828 1.0 0.5393813144027504 0.5955731491713766 22.639743470689513 -10.096352325884423 5.105004855267331 1.0000105410338964 0.5674772317868201 0.9874995207791679 0.02294022048582746 2.7522372549394086e-06 4.871913013981202e-07 0.02221231378426343 0.007403924324491157 8.010279575161508e-11 10.096352325884423 -0.43253330924707634 VK(ub)GDVDVSLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKGDVDVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 6807090.0 2980100.0 2827000.0 999990.0 True False 2478085.1908147484 2811770.389884438 1209083.2855686424 1.0 1.134654450261244 0.4879102986653652 21.240794354160784 -6.852366344018337 1.2234470389159005 1.072038156028103 0.46082796249328517 0.9436913249820059 0.066114221289489 0.15488248649423367 0.4449068134547649 0.04225536510000642 0.09795119965331331 1.404861969326821e-07 6.852366344018337 -0.6112101935348178 down VK(ub)GDVDVSLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKGDVDVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 16019100.0 4307600.0 7499800.0 4211700.0 True False 5576273.115490336 7082429.537145949 3445213.8156913556 1.0 1.270100906189774 0.6178344826979317 22.410869792781963 -6.794249452532339 1.4792551278550559 1.1501336113509006 0.610058242704379 0.8147916871629868 0.11516109255277528 0.22908895014268954 0.9901537558471957 0.0612624508935373 0.14300290448692457 1.6060185139941398e-07 6.794249452532339 -0.5400753686465216 VK(ub)GGGHVAQIYAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKGGGHVAQIYAIR 14 1 P62249;M0R210;M0R3H0;M0R1M5;M0QX76 P62249 RPS16 40S ribosomal protein S16 1 7206240.0 950240.0 1885700.0 4370300.0 True False 1245773.8421372508 1604360.9104010276 3918103.2788777836 1.0 1.287842830002422 3.145116028568943 20.248610754506785 -6.934317547505315 0.7104668218370687 0.97577025136917 3.572005284656393 0.9973207184509635 0.0492080020014844 0.0904572626294001 0.06714844186561433 0.04604357928248388 0.1642450809762358 1.1632751546725634e-07 6.934317547505315 2.596235033287223 up VK(ub)GGGHVAQIYAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKGGGHVAQIYAIR 14 1 P62249;M0R210;M0R3H0;M0R1M5;M0QX76 P62249 RPS16 40S ribosomal protein S16 1 35013200.0 2754700.0 5302500.0 26956000.0 True False 4179081.2955458625 4356227.446378409 21628134.78476551 1.0 1.0423887783713017 5.175332388919343 21.994754392961784 -6.909142791931917 0.9015499804966784 0.8685408503996608 5.699771876337114 0.9905941054993254 0.18992917017703267 0.10498766226470442 0.14186124092250635 0.15484149446331516 0.42493749146776566 1.2326994666272086e-07 6.909142791931917 4.831231025937454 up VK(ub)GGGHVAQIYAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKGGGHVAQIYAIR 14 1 P62249;M0R210;M0R3H0;M0R1M5;M0QX76 P62249 RPS16 40S ribosomal protein S16 1 7862640.0 950240.0 1460900.0 5451500.0 True False 1301569.4072704397 1396352.6074497353 4163967.9771667668 1.0 1.0728222403275967 3.1991901114971264 20.311820816029677 -6.914171056241475 0.8668402407658568 0.9425267196984373 3.499998631170764 0.9924028756197093 0.08890272269680079 0.10172417212738419 0.12428122449457252 0.07432157546490431 0.21160623712331955 1.2185095681414917e-07 6.914171056241475 2.5574719114723266 up VK(ub)GHFGPINSVAFHPDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKGHFGPINSVAFHPDGK 18 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 272385000.0 114810000.0 136670000.0 20905000.0 True False 150517021.82162157 116279368.73548742 18741951.13491981 1.0 0.7725330153907154 0.12451715366206877 27.165351408269974 -7.167816142267699 0.6327337184269489 1.0004758370761184 2.7252462899420885e-26 0.9978120711688959 0.01734920155926589 0.08381802579910141 0.057085086667756815 0.016701030172001658 0.05229194491853131 6.79491233039901e-08 7.167816142267699 -1.0004758370761184 down VK(ub)GHFGPINSVAFHPDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKGHFGPINSVAFHPDGK 18 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 300796000.0 114810000.0 155300000.0 30686000.0 True False 157258359.62358886 148438332.4915763 23438598.798007816 1.0 0.9439137788723981 0.14904516907152077 27.228561469792865 -6.921134371148685 0.8162767621287943 1.0168319558290588 0.01746355559854007 0.9944900302384206 0.028845415365160058 0.09750921663363794 0.1021920303774344 0.02500360744966924 0.07572865860219385 1.199128234268322e-07 6.921134371148685 -0.9993684002305188 down VK(ub)GHFGPINSVAFHPDGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKGHFGPINSVAFHPDGK 18 1 Q13347 Q13347 EIF3I Eukaryotic translation initiation factor 3 subunit I 1 471149100.0 195817800.0 248552300.0 26779000.0 True False 162831176.8994072 247213299.4261311 32378365.087893598 1.0 1.5182184648757586 0.1988462265300465 27.278801714550124 -6.800142987212891 1.4552298566698634 1.2858640375498311 0.18054107683087328 0.8326363404071653 0.2220371926807579 0.22053454557413638 0.9219920106549664 0.12003094364285806 0.2791357674027798 1.5843714677610898e-07 6.800142987212891 -1.1053229607189579 down VK(ub)GLSFHPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKGLSFHPK 9 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ITV3;A0A3B3ISK1;A0A3B3ITX2;A0A3B3IS23;A0A3B3IU84 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 9721300.0 1848100.0 3683200.0 4190000.0 True False 2392401.881497285 3478226.68220699 3427462.993030555 1.0 1.4538638801061892 1.4326451669923772 21.19002832664571 -10.064789732583783 4.712928041805824 0.9999829475367761 1.4432545235582281 0.9982842760265351 0.008662503389762507 1.5784374893369581e-06 3.132147567318246e-07 0.008387760610096362 0.002795810942083031 8.614107106587455e-11 10.064789732583783 0.44327157602145206 VK(ub)GPLPVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKGPLPVLK 9 1 Q2VPB7 Q2VPB7 AP5B1 AP-5 complex subunit beta-1 1 5387070.0 898660.0 994010.0 3494400.0 True False 870132.5302016139 1390923.3766936709 2579111.8102470743 1.0 1.5985189938495774 2.964044810104366 19.73087562953953 -6.957390819310405 0.47077445648356425 0.9642027799647468 3.6544132189711855 0.9996608265571687 0.015137501533807446 0.08064679513355033 0.024678304578860572 0.018908188507311186 0.11269808477993459 1.1030855122967182e-07 6.957390819310405 2.6902104390064387 VK(ub)GPLPVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKGPLPVLK 9 1 Q2VPB7 Q2VPB7 AP5B1 AP-5 complex subunit beta-1 1 4166760.0 898660.0 2067500.0 1200600.0 True False 747275.6073882019 2056361.967133379 1451639.9090528027 1.0 2.751811977806363 1.942576332882616 19.511280904973805 -10.369465508989732 7.45995733822665 0.9999733517229362 2.3471941553444893 0.7870208344213296 0.3303690686225414 0.00014642532128380685 1.2375724847680351e-05 0.319884733073291 0.10662615840642979 4.271048381134856e-11 10.369465508989732 1.347220803621553 VK(ub)GTNIQENEYVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKGTNIQENEYVK 13 1 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 1 6449500.0 1164100.0 3230800.0 2054600.0 True False 1526146.3731604342 2748777.23355976 1842009.7011148657 1.0 1.8011229341438786 1.2069679118001788 20.54146190745047 -10.187044938016605 5.518458002510747 0.9999835485126047 1.5040454229720779 0.48968504330246854 0.24256277214250924 4.909865485949006e-05 7.2332884586893545e-06 0.23486805183336987 0.07828679807646148 6.500624225591999e-11 10.187044938016605 0.5040618744594731 VK(ub)GTNIQENEYVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKGTNIQENEYVK 13 1 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 1 6800500.0 1607000.0 1736400.0 3457100.0 True False 1555986.6646273255 2429753.575206375 2551581.7992230905 1.0 1.5615516703598007 1.6398481151727737 20.569398265279084 -11.551924425780465 0.33361398090024763 5.4551334168869325e-14 1.6549313274568158 0.9994779778788662 0.006510958761784189 4.033599748787799 0.17400027149045852 2.9154149431350516 0.024720085718839543 2.805921870970693e-12 11.551924425780465 1.6549313274567612 VK(ub)GTNIQENEYVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKGTNIQENEYVK 13 1 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 1 5248100.0 1607000.0 2316500.0 1324600.0 True False 1336291.7021708314 2304020.5547107514 1601567.735741583 1.0 1.7241898239492366 1.1985165612716187 20.34980354071336 -10.212524267725696 3.923959946286788 0.999629667017455 1.4613531924329517 0.5066621457692089 0.2146052112396039 152242134.76062867 173036527.87287828 632096.7926249277 0.07853745858082362 6.130215364667243e-11 10.212524267725696 0.46172352541549666 VK(ub)GTNIQENEYVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKGTNIQENEYVK 13 1 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 1 22163000.0 3046900.0 2727100.0 16389000.0 True False 3944272.1133781006 2575334.4876864376 13406370.165340768 1.0 0.6529302273419401 3.3989465685872227 21.911327655289238 -6.875187075835414 1.1062255498053766 0.7959513088651454 3.576497716794042 0.9695944943993439 0.21289551437995904 0.13198191985040159 0.2987394456641027 0.1488304297549917 0.35591829248105566 1.3329471307997401e-07 6.875187075835414 2.7805464079288966 up VK(ub)HLDGEEDGSSDQSQASGTTGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKHLDGEEDGSSDQSQASGTTGGR 24 1 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 6259800.0 1798900.0 2736900.0 1724000.0 True False 2358375.3205723814 2328565.1883526407 1545617.017775734 1.0 0.9873598862913365 0.6553736397651118 21.169361901738633 -6.914942212069291 0.8613915757933401 1.008743038006385 0.6076041108375385 0.9926569653968155 0.013673157426669216 0.10124005064680967 0.1217078904981439 0.011475493564632787 0.03287529852741583 1.2163478391023338e-07 6.914942212069291 -0.4011389271688466 VK(ub)HLDGEEDGSSDQSQASGTTGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKHLDGEEDGSSDQSQASGTTGGR 24 1 Q5H909;Q9UNF1-2;Q9UNF1;Q5H907 Q5H909 MAGED2 Melanoma-associated antigen D2 1 5484400.0 1798900.0 2258300.0 1427200.0 True False 2464001.943444596 2158520.838800555 1090124.7541066527 1.0 0.8760223767449679 0.44242041164248963 21.232571963261524 -6.9479614731266 0.5807975232927401 1.0051676912133554 0.29179923625729515 0.9990314058643194 0.007439567841678276 0.08431489689579524 0.039431557503092275 0.007788013614133065 0.03622913287877583 1.1272974558803411e-07 6.9479614731266 -0.7133684549560602 down VK(ub)MIMATNRPDTLDPALLRPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKMIMATNRPDTLDPALLRPGR 22 3 A0A087X2I1;P62333 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 27804400.0 9855100.0 10483500.0 7465800.0 True False 9542255.244909003 14669616.220730295 5510283.010800876 1.0 1.5373321970775042 0.5774612886970016 23.185898846679653 -6.75479625034853 1.632105735717186 1.3141233908430392 0.5748335503052526 0.6693572761526745 0.22586527731380268 0.2917447533078645 1.5303788830215086 0.10925791418043397 0.263925801480073 1.7587485389142195e-07 6.75479625034853 -0.7392898405377866 VK(ub)MIMATNRPDTLDPALLRPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKMIMATNRPDTLDPALLRPGR 22 3 A0A087X2I1;P62333 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 16678500.0 6875900.0 4856000.0 4946600.0 True False 9418106.044210738 4641445.863355402 3778314.9584248597 1.0 0.49282157596945675 0.4011756653289512 23.16700553623807 -13.999999999999984 0.24063786332475767 4.367441571884323 0.3608992528976392 0.9995260228653593 0.005733580180070257 13.646060334381882 0.15525687048158648 22.090035078544375 0.044614567305265015 1.0000000000000368e-14 13.999999999999984 -4.006542318986684 VK(ub)MIMATNRPDTLDPALLRPGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKMIMATNRPDTLDPALLRPGR 22 3 A0A087X2I1;P62333 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 29235500.0 9855100.0 13370800.0 6009600.0 True False 8194952.304955677 13298768.84650401 7266179.57474907 1.0 1.6228000300211556 0.8866652671492723 22.96630412211393 -6.682470917771197 1.8930018631599763 1.3931770103632453 0.8894059086743769 0.3354770238536826 0.2638164348922103 0.43308083312391465 3.0025573688725773 0.11173748096371891 0.29378198117166526 2.077442835433608e-07 6.682470917771197 -0.5037711016888684 VK(ub)NEEPTTQEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKNEEPTTQEGK 12 1 Q5M775-4;Q5M775;Q5M775-5;Q5M775-3;Q5M775-2 Q5M775-4 SPECC1 Cytospin-B 1 12645100.0 709100.0 4427900.0 7508100.0 True False 929636.9669341678 3767274.57981902 6731233.834780739 1.0 4.0524147746007175 7.240712314807734 19.82630791296434 -7.051582898604425 0.2542265489915555 5.337899890381257e-24 11.13041741630675 0.9999859861528612 0.009538310571515234 0.0737279312097172 0.009157813372712834 0.07482099039705334 0.3009505254206151 8.880084561179367e-08 7.051582898604425 11.13041741630675 VK(ub)NEEPTTQEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKNEEPTTQEGK 12 1 Q5M775-4;Q5M775;Q5M775-5;Q5M775-3;Q5M775-2 Q5M775-4 SPECC1 Cytospin-B 1 6027290.0 985690.0 3703500.0 1338100.0 True False 1495363.793591535 3042581.489422424 1073623.9484899344 1.0 2.034676446267843 0.7179683987876461 20.51206507673287 -6.697143251577281 1.8409482183932695 1.644282489205194 0.7220758061253408 0.40405961370983345 0.43698247723833256 0.4015066662397911 2.6434087578670074 0.18950799249627495 0.4891103036558464 2.0084302247442397e-07 6.697143251577281 -0.9222066830798531 VK(ub)NEGGECKPEGLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKNEGGECKPEGLFR 15 2 O43683-2;O43683-3;O43683 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 3125410.0 619370.0 663840.0 1842200.0 True False 812000.0679876129 564797.6596280535 1651586.8156301954 1.0 0.6955635619930386 2.033973740572877 19.631120322642076 -6.846926656537318 1.2499684609698656 0.8378834916491275 2.084347810326761 0.9356924285734554 0.14526156470221707 0.1608718189830958 0.48525358872660423 0.09100748513348073 0.21020740934459436 1.422569009671796e-07 6.846926656537318 1.2464643186776336 up VK(ub)NEGGECKPEGLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKNEGGECKPEGLFR 15 2 O43683-2;O43683-3;O43683 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 18864000.0 1173600.0 6233600.0 11456800.0 True False 1780437.0016526738 5121165.376660895 9192358.45830617 1.0 2.8763530368708476 5.162978779801503 20.76379995812191 -6.9684791551596605 0.2922418737671174 0.5650212641282821 7.545179212181689 0.9999679682093724 0.009634318301114983 0.0767993775753043 0.01078756210913953 0.03947405546089407 0.2068294272230342 1.075278209302425e-07 6.9684791551596605 6.980157948053407 VK(ub)NEGGECKPEGLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKNEGGECKPEGLFR 15 2 O43683-2;O43683-3;O43683 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 2636120.0 619370.0 500950.0 1515800.0 True False 848367.8268448944 478816.3725798784 1157799.2588809314 1.0 0.5643971369831539 1.3647373488771042 19.694330384164967 -6.758936685188236 1.616798485093271 0.7466391470625388 1.3674754386290493 0.686485782331013 0.18318688455503604 0.28470777770106837 1.4666303480471714 0.08941282927338033 0.2150714209669464 1.7420608259933595e-07 6.758936685188236 0.6208362915665105 VK(ub)NEGGECKPEGLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKNEGGECKPEGLFR 15 2 O43683-2;O43683-3;O43683 O43683-2 BUB1 Mitotic checkpoint serine/threonine-protein kinase BUB1 1 20095800.0 1173600.0 2739300.0 16182900.0 True False 1519248.3351145557 2586855.5469617727 13237778.25057617 1.0 1.7027206725664876 8.713373544410041 20.53492628021436 -6.9262347453651465 0.7770810648917409 0.8772030189889831 10.023682843672166 0.9957450134456756 0.22715286935368012 0.09464047192568577 0.08760860216190842 0.2024869582195604 0.6479709784815411 1.1851279882338062e-07 6.9262347453651465 9.146479824683183 up VK(ub)NSLLSLSDT ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKNSLLSLSDT 11 1 Q7L2H7;Q7L2H7-2 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 1 27849800.0 3802800.0 10199000.0 13848000.0 True False 5769125.621919553 8378908.764849286 11110936.730205992 1.0 1.4523706561379024 1.9259308010195602 22.45992124755191 -6.97054815276702 0.24474219592178392 0.8396510630440864 2.552428503323771 0.9999863471290495 0.0013968478137855603 0.07612525785516767 0.008391342412364108 0.010949875436980838 0.04578683502935061 1.070167720584378e-07 6.97054815276702 1.7127774402796847 VK(ub)NSLLSLSDT ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKNSLLSLSDT 11 1 Q7L2H7;Q7L2H7-2 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 1 27613800.0 3802800.0 12160000.0 11651000.0 True False 4922799.56439471 11483285.310500927 9530637.54935538 1.0 2.3326737479942214 1.9360198246314817 22.23104756964436 -10.051430667576305 4.613340579429345 0.9999528466609018 2.134346786357559 0.9159983574201044 0.161933286278075 56088755.40354704 2.344097688741843 28430.143275519084 0.05543407104203393 8.883197797498547e-11 10.051430667576305 1.1343939396966571 VK(ub)PAPDETSFSEALLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKPAPDETSFSEALLK 16 1 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 1 75601500.0 28256900.0 36084600.0 11260000.0 True False 27359900.176545043 50493368.95870306 8310668.207240738 1.0 1.8455246047275335 0.3037536012052144 24.70555963072679 -6.757819578633028 1.620759441363537 1.4924669998859992 0.2987387946914347 0.6819449744163373 0.3555272373164097 0.28660991896799515 1.483364803579932 0.1731201988407126 0.4169222400222301 1.7465475801805897e-07 6.757819578633028 -1.1937282051945646 VK(ub)PAPDETSFSEALLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKPAPDETSFSEALLK 16 1 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 1 121060800.0 21057800.0 18429000.0 81574000.0 True False 31946222.131391995 15140200.963565798 65450863.14484563 1.0 0.4739277433586822 2.048782572025324 24.929141996492966 -6.816635741469461 1.3863579335755891 0.7154510190650836 2.0807478079474473 0.8764747776046946 0.23007729652743109 0.1978876026795829 0.7482304059036696 0.13044346427975143 0.30095548063776945 1.5253315683268266e-07 6.816635741469461 1.3652967888823637 up VK(ub)PAPDETSFSEALLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKPAPDETSFSEALLK 16 1 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 1 82313300.0 28256900.0 45793400.0 8263000.0 True False 23496864.34291909 45546701.86492184 9990755.096204665 1.0 1.9384161733328298 0.42519524947657256 24.485964906161065 -6.738982673070376 1.690481255502367 1.5590161456790776 0.4245172527273126 0.6003261868409353 0.3942930743581532 0.31966794572235924 1.7933271049183126 0.1845503082154419 0.45336602741153037 1.8239684712453752e-07 6.738982673070376 -1.134498892951765 VK(ub)PAPDETSFSEALLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKPAPDETSFSEALLK 16 1 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 1 99438300.0 21057800.0 20261000.0 58119500.0 True False 27259737.211294536 19133457.53914961 47542347.35642947 1.0 0.7018944236638509 1.7440500980593179 24.700268318585415 -6.830238986004334 1.3267848185683941 0.8407347053794455 1.772241342259394 0.906357207166463 0.13410930088995138 0.18052071590098787 0.6214045082650417 0.07935932401995945 0.18263240237655481 1.4782946800115482e-07 6.830238986004334 0.9315066368799484 VK(ub)PAPDETSFSEALLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKPAPDETSFSEALLKR 17 2 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 2 11473000.0 2254700.0 2985100.0 6233200.0 True False 2183125.782660384 4177065.9970908533 4600537.928008256 1.0 1.9133418835815446 2.107316932697292 21.05796382415705 -10.787453722229017 0.30501454397524863 2.710375882785347e-13 2.1635603528548724 0.9991861958901566 0.013773310422241693 2.508074145779823 0.15255995693496519 1.8955632328415621 0.06824358577944048 1.631346733836505e-11 10.787453722229017 2.1635603528546015 VK(ub)PAPDETSFSEALLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKPAPDETSFSEALLKR 17 2 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 2 48825300.0 2145100.0 9528200.0 37152000.0 True False 3254273.527816251 7827818.265833607 29808890.915699963 1.0 2.4053965344106736 9.159921764690424 21.63390408666511 -6.940691214014819 0.6531017978745997 0.924992649821617 11.019044890180414 0.9982530363147255 0.14887492250101936 0.08745271773323163 0.05318431958567254 0.14568901459561115 0.5796008070436922 1.146327697641266e-07 6.940691214014819 10.094052240358797 VK(ub)PAPDETSFSEALLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKPAPDETSFSEALLKR 17 2 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 2 10260100.0 2254700.0 3982700.0 4022700.0 True False 1874882.9501459734 3961244.4045959488 4863827.971136696 1.0 2.112795577071911 2.594203531883423 20.838369099591326 -9.709864994768193 0.22381577342981693 2.1953142047769036e-22 2.954751599818006 0.999277493945981 0.017945506027705584 1.1427898587136671 0.09486410691876947 0.9971842823600785 0.24534835951984899 1.9504508246878973e-10 9.709864994768193 2.954751599818006 VK(ub)PAPDETSFSEALLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKPAPDETSFSEALLKR 17 2 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 2 38232200.0 2145100.0 8169100.0 27918000.0 True False 2776874.2362425313 7714482.403783964 22837210.462870434 1.0 2.778117317341189 8.224070850890289 21.405030408757558 -6.95098420605131 0.5479318784168918 0.9237442705409163 10.333381094289825 0.9992762754607586 0.08267867957035357 0.08309292155474433 0.03434524820410321 0.0899778376708266 0.45161446185394605 1.1194785947050861e-07 6.95098420605131 9.409636823748908 VK(ub)PFMTGAAEQIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKPFMTGAAEQIK 13 1 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;E9PJF7;Q56UQ5 P13693 TPT1 Translationally-controlled tumor protein;TPT1-like protein 1 81666900.0 9375900.0 10069000.0 62222000.0 True False 12137287.376619441 9508651.298637643 50898234.451634236 1.0 0.7834247475226261 4.193542829815631 23.532942686662714 -6.891757364000734 1.0119491507230773 0.8244145670987675 4.497123160692229 0.9819987718984243 0.20916987554081523 0.11772808335376804 0.21362137959051125 0.15712319382774248 0.3942642136051857 1.2830472081411614e-07 6.891757364000734 3.672708593593461 up VK(ub)SSQQPAASTQLPTTPSSNPSGLNQHTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKSSQQPAASTQLPTTPSSNPSGLNQHTR 29 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0;H0Y2P2;C9JU75 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 59676000.0 15549000.0 32595000.0 11532000.0 True False 20384889.57673021 27731953.05431485 10338779.262755085 1.0 1.3604171339721884 0.5071785757700166 24.280996806098816 -6.791954241519735 1.4886137699730457 1.200925053846574 0.4976212842207244 0.8075700293554611 0.15341479418310205 0.2324477705287748 1.0175529660935994 0.08111225261413586 0.18962885948567923 1.6145286591164846e-07 6.791954241519735 -0.7033037696258497 VK(ub)SSQQPAASTQLPTTPSSNPSGLNQHTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKSSQQPAASTQLPTTPSSNPSGLNQHTR 29 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0;H0Y2P2;C9JU75 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 63480000.0 21451000.0 21481000.0 20548000.0 True False 20770049.74668375 30058475.321935162 15165862.373213392 1.0 1.4472028564464294 0.73017939572508 24.308001335820578 -6.7380777174394 1.693911563934883 1.2666815679712373 0.7299492430960044 0.5961725103400468 0.18790612077979438 0.3213221410515434 1.8095939835324015 0.08778691376692545 0.21586269040610515 1.8277731050184106e-07 6.7380777174394 -0.5367323248752329 VK(ub)SSQQPAASTQLPTTPSSNPSGLNQHTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKSSQQPAASTQLPTTPSSNPSGLNQHTR 29 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0;H0Y2P2;C9JU75 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 66683000.0 35173000.0 17139000.0 14371000.0 True False 53360012.49073749 14080411.542381812 11530565.550966939 1.0 0.26387571676123506 0.21609000846782925 25.669255668446233 -13.70426834984141 0.3912747967222869 9.999999999636618 0.21264366960323264 0.9998190607497366 0.00482643074541725 20.074144323383667 0.20473971327838103 151.466499150042 0.012535497511790896 1.9757484511682012e-14 13.70426834984141 -9.787356330033385 VK(ub)SSQQPAASTQLPTTPSSNPSGLNQHTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKSSQQPAASTQLPTTPSSNPSGLNQHTR 29 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0;H0Y2P2;C9JU75 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 68645700.0 35173000.0 28513000.0 4959700.0 True False 45532141.86348355 26926226.48505861 4057085.49081949 1.0 0.5913674468859821 0.08910376988158432 25.440381990538683 -7.654657045990545 0.5090498189885646 1.0159130335871618 1.826825151649094e-24 0.9956060172201077 0.02469368352786535 0.11721845579540702 0.09046042693796308 0.028448233749386466 0.07460913743552473 2.2148430382036187e-08 7.654657045990545 -1.0159130335871618 down VK(ub)SSYSMENANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKSSYSMENANK 12 1 Q9UGI0 Q9UGI0 ZRANB1 Ubiquitin thioesterase ZRANB1 1 2010630.0 853250.0 868650.0 288730.0 True False 709515.1803841093 863970.4100364747 349102.1080633152 1.0 1.2176912262381028 0.49202908932029094 19.436474026137134 -6.826288683424352 1.3445042663680802 1.1166478570379483 0.4739534102808822 0.8982318500104367 0.09699488104455344 0.1854329067943788 0.6568802597306482 0.05666486763726375 0.13043346050408258 1.4918024517641733e-07 6.826288683424352 -0.6426944467570661 down VK(ub)SWVIDQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKSWVIDQK 9 1 J3KQ32;Q9NTK5;Q9NTK5-2;Q9NTK5-3;C9JCJ9 J3KQ32 OLA1 Obg-like ATPase 1 1 7719200.0 2702500.0 3269100.0 1747600.0 True False 3543003.671047225 2781363.022851995 1566775.1161629194 1.0 0.7850296756903705 0.44221662228755726 21.75654152961497 -6.964219857888358 0.3711982883580411 1.0260070335804476 0.18928396300201614 0.9998961485710725 0.0023408000581109484 0.07822669875110562 0.015799535550148947 0.004510470658690315 0.02909628175423132 1.0858757690750728e-07 6.964219857888358 -0.8367230705784315 down VK(ub)SWVIDQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKSWVIDQK 9 1 J3KQ32;Q9NTK5;Q9NTK5-2;Q9NTK5-3;C9JCJ9 J3KQ32 OLA1 Obg-like ATPase 1 1 9057700.0 2931800.0 4488700.0 1637200.0 True False 2838731.6137861847 6281061.318261262 1208368.2050528023 1.0 2.212629502471295 0.4256718737285382 21.436815026078303 -6.72397185004997 1.745186401563309 1.7346069675933764 0.4278455090349117 0.5311301717636676 0.510045810345843 0.34765098084119345 2.0713794127032537 0.2318784482106752 0.5793642556099706 1.888113728234906e-07 6.72397185004997 -1.3067614585584648 VK(ub)TDRPLPENPYHSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKTDRPLPENPYHSR 15 2 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 3946200.0 1096000.0 1179200.0 1671000.0 True False 1436866.6136790984 1003267.9564855985 1498100.9493638375 1.0 0.6982331880596278 1.0426165763069326 20.454494709953487 -6.675190833995807 1.9187007364114388 0.8082554366582186 1.0412702087971621 0.302395199383791 0.12803166901953478 0.4492847343307894 3.193424525528037 0.053623484610403664 0.14231993297452183 2.112560552426836e-07 6.675190833995807 0.2330147721389435 VK(ub)TDRPLPENPYHSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKTDRPLPENPYHSR 15 2 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 51895000.0 4605000.0 12284000.0 35006000.0 True False 6986121.670595223 10091824.224669935 28087048.756325137 1.0 1.44455317277778 4.02040646880576 22.73606033831458 -6.936579091092224 0.6906668540699336 0.9686742830833296 4.6502617649833065 0.9976804401815051 0.06412638844699015 0.08936281034994886 0.06198263143062556 0.06090862699941339 0.22524248091459265 1.157233264557005e-07 6.936579091092224 3.6815874818999768 up VK(ub)TDRPLPENPYHSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKTDRPLPENPYHSR 15 2 P51970 P51970 NDUFA8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 1 55461400.0 4605000.0 8161400.0 42695000.0 True False 5961263.278120758 7707210.915552821 34924948.087694384 1.0 1.292882155337796 5.858648822956232 22.50718666040703 -6.919960891146592 0.825007815805294 0.8991180894032954 6.5942799662755025 0.9941702451396461 0.16985234851758413 0.09819484929196647 0.10573060064785837 0.14631492154698628 0.4381249921851326 1.2023727051633844e-07 6.919960891146592 5.695161876872207 up VK(ub)TDTVLILCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKTDTVLILCR 11 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 72710000.0 25022000.0 32915000.0 14773000.0 True False 32804084.31339267 28004210.30166512 13244431.672622366 1.0 0.8536805976392414 0.40374337372420316 24.967372114781735 -6.950893841483153 0.5489416828161567 1.0062618852556624 0.23006297670157919 0.9992695825736743 0.006857155044945034 0.08312877064608222 0.03449203641224098 0.007452753743704702 0.037318716744532424 1.1197115512107049e-07 6.950893841483153 -0.7761989085540832 down VK(ub)TDTVLILCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKTDTVLILCR 11 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 46615600.0 21633000.0 19324000.0 5658600.0 True False 20946272.256305534 27040173.97332877 4176442.905638762 1.0 1.2909301303094045 0.1993883615439741 24.320190178977874 -6.835790144841125 1.301704755383987 1.154952431035704 0.16635650469704233 0.9169847863428566 0.13297745649287185 0.1737756238555289 0.5737677440798576 0.08015287277796232 0.18451008005838732 1.4595193433188075e-07 6.835790144841125 -0.9885959263386617 down VK(ub)TDTVLILCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKTDTVLILCR 11 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 178793000.0 56613000.0 71545000.0 50635000.0 True False 85886059.96469234 58777235.766363606 40626970.05589114 1.0 0.6843629314294644 0.47303334292658017 26.35592065294628 -8.244318983494216 0.1343763931053145 1.426042012274037 6.407087301741231e-13 0.9999528094468898 0.0014874739183586084 0.08561046786027963 0.02760104919912134 0.13218614371621923 0.135644963636294 5.6974564799668895e-09 8.244318983494216 -1.4260420122733963 down VK(ub)TDTVLILCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKTDTVLILCR 11 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 80565000.0 25022000.0 41647000.0 13896000.0 True False 34273309.59412454 39806897.83178799 10614050.997103453 1.0 1.161454738488753 0.3096885338124164 25.030582176304627 -6.857641121271087 1.197563395218932 1.087107407252616 0.2702533001321065 0.9507171782270616 0.08200568533307222 0.14924558043945735 0.40806445549606507 0.0534575679013391 0.12447582637754255 1.3879022465079522e-07 6.857641121271087 -0.8168541071205093 down VK(ub)TDTVLILCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKTDTVLILCR 11 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 48347000.0 21633000.0 13782000.0 12932000.0 True False 17988798.004394308 13707753.630487178 15636021.40918781 1.0 0.7620160961915656 0.8692087934595875 24.10059545441215 -10.130395492486821 4.836456851963383 1.0000114796039916 0.815612444824491 0.797784644876011 0.04376123541362241 5.417204768241469e-06 9.740043710581429e-07 0.042374271351166226 0.014123877996669313 7.40635470633933e-11 10.130395492486821 -0.1843990347795006 VK(ub)TDTVLILCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKTDTVLILCR 11 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 151135000.0 56613000.0 64512000.0 30010000.0 True False 73286644.50906649 60921850.48939433 24548487.928603124 1.0 0.8312817553252492 0.3349653691071388 26.12704697503873 -6.951890981282666 0.537681675725659 1.0074205729659107 0.13599742635986808 0.999341455973668 0.007243539638002909 0.08273515865792593 0.03288753805256046 0.007992681515909004 0.04108717698966454 1.1171436434275974e-07 6.951890981282666 -0.8714231466060426 down VK(ub)TEALIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKTEALIR 8 1 Q9NUJ7 Q9NUJ7 PLCXD1 PI-PLC X domain-containing protein 1 1 102228000.0 21893000.0 36279000.0 44056000.0 True False 28701935.01211358 30866314.61443439 39497507.73499293 1.0 1.0754088392091803 1.376127000438232 24.774644667254513 -6.944945171782876 0.6118354918993746 0.9966820397997513 1.4705635088142865 0.9987424408933845 0.005761774867918061 0.0855813912853815 0.044869046723557106 0.0058465828139550565 0.025373765819282846 1.1351541160143686e-07 6.944945171782876 0.4738814690145352 VK(ub)TEALIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKTEALIR 8 1 Q9NUJ7 Q9NUJ7 PLCXD1 PI-PLC X domain-containing protein 1 1 123919000.0 37072000.0 32272000.0 54575000.0 True False 35895169.65218683 45158377.89625671 40280170.28509448 1.0 1.2580628071639588 1.1221613012390512 25.097286380468812 -10.337578353465581 5.517940619997519 0.99995794779088 1.190112054201475 0.7229312729018991 0.05548155746531786 2.8709753642645787e-05 3.4464986000526536e-06 0.05373165426446245 0.01790659567373406 4.5964405412788825e-11 10.337578353465581 0.19015410641059494 VK(ub)TEALIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKTEALIR 8 1 Q9NUJ7 Q9NUJ7 PLCXD1 PI-PLC X domain-containing protein 1 1 213711000.0 112670000.0 66139000.0 34902000.0 True False 170928627.28033987 54335978.703634396 28003604.401909966 1.0 0.31788694245182236 0.16383214940339563 27.348818800212836 -13.999999999999998 0.20906327328974453 4.92979356288547 0.07226570733922148 0.9994895072598354 0.008209485937472798 12.724931140810165 0.14493068938344578 20.531521562886194 0.09185708634210031 1.0000000000000041e-14 13.999999999999998 -4.857527855546248 VK(ub)TEALIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKTEALIR 8 1 Q9NUJ7 Q9NUJ7 PLCXD1 PI-PLC X domain-containing protein 1 1 76178000.0 21893000.0 23151000.0 31134000.0 True False 29987433.736079004 22128112.26988076 23780790.424857393 1.0 0.7379128359109169 0.7930251929576032 24.837854728777405 -10.74449505436976 6.9035523909283425 1.0040393217656876 0.7654690144342642 0.9602318918300002 0.022499525547743704 0.001417066047486762 5.244647932645753e-05 0.022069515315700665 0.007261690645331642 1.8009636432208957e-11 10.74449505436976 -0.23857030733142337 VK(ub)TEALIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKTEALIR 8 1 Q9NUJ7 Q9NUJ7 PLCXD1 PI-PLC X domain-containing protein 1 1 121572000.0 37072000.0 60986000.0 23514000.0 True False 30827010.568062905 60657456.31322679 28430668.68354791 1.0 1.9676723495228736 0.9222648631717267 24.87769165590309 -6.663462554346548 1.9602881922364008 1.621074508338704 0.9265580560544276 0.25060464955707085 0.4116702234758283 0.4762562062670575 3.521584961084021 0.16944179260957196 0.4566436792373934 2.170388330297029e-07 6.663462554346548 -0.6945164522842763 VK(ub)TEALIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKTEALIR 8 1 Q9NUJ7 Q9NUJ7 PLCXD1 PI-PLC X domain-containing protein 1 1 229257000.0 112670000.0 79262000.0 37325000.0 True False 145853536.0577344 74851000.02310224 30532232.98684142 1.0 0.5131929060223357 0.20933488355575827 27.119945122305285 -8.44932195863606 0.2649333049175368 1.2100716179227686 7.409218460685451e-12 0.9992296307555978 0.009038731484610235 0.1449007354179177 0.06850423159214689 0.12183914095475121 0.10533889954722393 3.5536777355863346e-09 8.44932195863606 -1.2100716179153594 down VK(ub)TLHPAVHAGILAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKTLHPAVHAGILAR 15 1 P31939-2;P31939;C9JLK0 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 1 29302300.0 14314000.0 7623900.0 7364400.0 True False 21715384.493572216 6263355.479197427 5908823.112068812 1.0 0.28842940731956135 0.27210308497267605 24.372214161652618 VK(ub)TSQPPVPQGEAEEDSQGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKTSQPPVPQGEAEEDSQGK 20 1 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 11610700.0 2417300.0 3754100.0 5439300.0 True False 2340564.1346631236 5253131.707372871 4014584.154497739 1.0 2.2443869960986786 1.7152207431716269 21.15842486673582 -9.921305893205316 5.613247704663254 0.9999991367027979 1.9798038696370133 0.8205063161267705 0.21603121813520296 2.333598285129593e-06 4.48662938330087e-07 0.2091715145086914 0.0697237758405907 1.1986547391184372e-10 9.921305893205316 0.9798047329342153 VK(ub)TSQPPVPQGEAEEDSQGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKTSQPPVPQGEAEEDSQGK 20 1 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 21185600.0 8271700.0 3597300.0 9316600.0 True False 12548773.642272014 2955333.7091668127 7475169.926389158 1.0 0.235507770991376 0.5956892792462343 23.581043044589798 -10.646518030309009 6.62103061171052 1.0026686791422224 0.41559852512665074 0.7782750402578256 0.14704348500174166 0.005809362431183483 0.00031014828705169036 0.14278753358546417 0.0474580807150038 2.256742301915085e-11 10.646518030309009 -0.5870701540155716 VK(ub)TSQPPVPQGEAEEDSQGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKTSQPPVPQGEAEEDSQGK 20 1 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 11179000.0 2417300.0 5327900.0 3433800.0 True False 2010092.0545473276 5299197.545194649 4151791.7039026506 1.0 2.636295951325487 2.06547341675734 20.938830142170097 -10.598391208080955 7.0529755342455385 0.9980135332778574 2.3508846840414135 0.881900870012208 0.23303732389569526 0.00728225717686866 0.00041466395723490415 0.2257335528780041 0.07521247287439764 2.52120866999644e-11 10.598391208080955 1.3528711507635562 VK(ub)TSQPPVPQGEAEEDSQGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKTSQPPVPQGEAEEDSQGK 20 1 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 27760300.0 8271700.0 5345600.0 14143000.0 True False 10707878.709583404 5048112.660839951 11569119.119434657 1.0 0.47143909617896207 1.080430534675412 23.352169366682247 -6.677213345942492 1.911856771197389 0.6647414513975324 1.0780619686026043 0.31141388810553183 0.22415413951176005 0.44472737491078124 3.1404192208235324 0.09416377099146714 0.2492345362116557 2.1027452183305627e-07 6.677213345942492 0.4133205172050719 VK(ub)VFNIDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKVFNIDLK 9 1 Q16666;Q16666-2;Q16666-3;Q16666-6;A0A0A0MRB1 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 2791340.0 514840.0 1167100.0 1109400.0 True False 674960.2257176514 992973.2293201674 994609.9301162418 1.0 1.4711581386360784 1.473583023442193 19.364442963488305 VK(ub)VNKDDIQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKVNKDDIQK 10 2 P35579;Q5BKV1;B1AH99 P35579 MYH9 Myosin-9 1 3494780.0 1380200.0 702680.0 1411900.0 True False 2093864.3061358368 577281.2639361016 1132837.346142247 1.0 0.2757013729325453 0.5410271061131292 20.99773652008951 -10.329253432146423 5.748772734118083 1.0000824299118836 0.40836423952373313 0.8689319222070946 0.10831877698705426 0.00011445257906154068 1.3353868556900273e-05 0.10489369158504536 0.03495973494603326 4.6853988633315527e-11 10.329253432146423 -0.5917181903881504 VK(ub)VNKDDIQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKVNKDDIQK 10 2 P35579;Q5BKV1;B1AH99 P35579 MYH9 Myosin-9 1 3094080.0 1380200.0 797180.0 916700.0 True False 1786696.1078093965 752816.2322224604 749870.0061363032 1.0 0.4213454257453223 0.4196964457798544 20.76886284218196 VK(ub)VSQAAADLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKVSQAAADLK 11 1 P63218 P63218 GNG5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 1 3115900.0 1985900.0 0.0 1130000.0 True False 2603534.1314829574 0.0 1013078.4397253956 1.0 0.0 0.38911663475998 21.31203988943756 -10.677781582714003 6.640447966845937 1.0058392822391402 0.194558317379999 0.85103037704017 0.1588562009318132 0.0137228688504243 0.0006658823110918857 0.1536992891932655 0.05127061838755766 2.099995757167425e-11 10.677781582714003 -0.8112809648591413 VK(ub)VSQAAADLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKVSQAAADLK 11 1 P63218 P63218 GNG5 Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-5 1 6299300.0 1985900.0 2664800.0 1648600.0 True False 2720140.896929581 2547060.324684822 1259234.6339827827 1.0 0.9363707326925133 0.4629299296239292 21.375249950960452 -6.931470672004832 0.7346189818899213 1.0068211226017154 0.3619915011073203 0.996819492783783 0.013512028419394497 0.0918813314433093 0.07399137259998666 0.012419595939733586 0.04249707536186993 1.1709256725004943e-07 6.931470672004832 -0.6448296214943952 down VK(ub)YETELAMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKYETELAMR 10 1 P05783;F8VZY9;CON__P05784 P05783 KRT18 Keratin, type I cytoskeletal 18 1 12844310.0 1998010.0 3164700.0 7681600.0 True False 2619410.4587563607 2692539.095903981 6886781.719110262 1.0 1.0279179755517736 2.62913423747264 21.320810715463207 -6.9106829335160285 0.89107373958758 0.951487639998219 2.8391143037875826 0.9911766919056145 0.07152827742464397 0.10396807131435581 0.1363313668748732 0.05875962544552664 0.16298047700256335 1.228335678055329e-07 6.9106829335160285 1.8876266637893635 up VK(ub)YETELAMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKYETELAMR 10 1 P05783;F8VZY9;CON__P05784 P05783 KRT18 Keratin, type I cytoskeletal 18 1 38036700.0 3855800.0 5787900.0 28393000.0 True False 3733399.7395582106 8099038.653499755 20956021.52825809 1.0 2.1693467666171076 5.613120209500498 21.83205855731235 -6.951865613881613 0.5379727418515906 0.9486116086288651 6.992337546487497 0.999339673293648 0.05031725838834861 0.0827451490150489 0.03292812882940044 0.055498645295617155 0.2851027933371791 1.1172088983633245e-07 6.951865613881613 6.043725937858632 VK(ub)YETELAMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKYETELAMR 10 1 P05783;F8VZY9;CON__P05784 P05783 KRT18 Keratin, type I cytoskeletal 18 1 24277310.0 1998010.0 5083200.0 17196100.0 True False 2736728.291190022 4858607.416105472 13134735.344796373 1.0 1.7753342309304605 4.7994298107997215 21.384020776986098 -6.945454396684209 0.6067007052692202 0.9663778144770799 5.7649822162162 0.9987945459724897 0.056911476832819795 0.08536402505784683 0.04392384136609382 0.0580313356665343 0.2547074509568812 1.1338238896163666e-07 6.945454396684209 4.79860440173912 VK(ub)YETELAMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKYETELAMR 10 1 P05783;F8VZY9;CON__P05784 P05783 KRT18 Keratin, type I cytoskeletal 18 1 26860700.0 3855800.0 5563200.0 17441700.0 True False 3206268.5409024856 5533229.937391254 21088678.828690894 1.0 1.725753743581873 6.57732768159056 21.612463832746627 -6.933592862951814 0.7166855989954762 0.935145440278088 7.671040412734865 0.9971984783492018 0.131048317246943 0.09081473542191652 0.06885206828942844 0.12205376623248394 0.43064083273338993 1.1652178716628745e-07 6.933592862951814 6.7358949724567765 VKDEYSERDENVLK(ub)SEPMGNAEEPEIPYSYSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKDEYSERDENVLKSEPMGNAEEPEIPYSYSR 32 3 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-14;A0A0C4DGN9 Q9UKT9 IKZF3 Zinc finger protein Aiolos 1 41949200.0 4499200.0 14839000.0 22611000.0 True False 6825615.335579174 12190864.512363818 18141925.93924663 1.0 1.7860462263113142 2.657918011388673 22.702527681521058 -6.969788505529974 0.2631885920316462 0.7645566792835979 3.7053829634484914 0.9999806858544601 0.0029758993803389363 0.07637138293194988 0.009275412714175828 0.01783252069344593 0.0818753765717977 1.0720412450877445e-07 6.969788505529974 2.9408262841648933 VKDLVLSVHNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKDLVLSVHNR 11 1 A0A499FI31;Q15020-4;Q15020 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 3288230.0 1130600.0 679530.0 1478100.0 False True 1482227.548745975 578146.7727871937 1325160.3909363768 1.0 0.3900526429132487 0.894033032956051 20.499335513761014 -10.15888048578261 7.610088331585207 1.000000142179589 0.6420428379346679 0.4021376729124675 0.2057491326622849 4.963223143581674e-07 5.50013709129427e-08 0.1992158182553736 0.06640524702480417 6.936166572711293e-11 10.15888048578261 -0.3579573042449211 VKDLVLSVHNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKDLVLSVHNR 11 1 A0A499FI31;Q15020-4;Q15020 A0A499FI31 SART3 Squamous cell carcinoma antigen recognized by T-cells 3 0 2935610.0 1130600.0 826430.0 978580.0 False True 1548613.3733161713 789915.5899614515 747459.5584877301 1.0 0.5100792770954452 0.4826637631877958 20.562545575283906 -13.999999999999986 0.4106460933360442 9.845127836745068 0.4814469795176241 0.9998522761080814 0.002888754217907777 28.40824713687283 0.21250804034623502 224.75558621159007 0.006816050424710934 1.0000000000000327e-14 13.999999999999986 -9.363680857227443 VKEGMNIVEAMER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKEGMNIVEAMER 13 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 33317000.0 2540900.0 17877100.0 12899000.0 False True 3331144.506110602 15209906.364390016 11564335.215945013 1.0 4.5659701452426305 3.4715801715391117 21.667586509264734 -9.574513757762547 14.783772978435076 0.999999997931439 4.018775158390871 0.9102744192713321 0.4467828358652535 0.0 0.0 0.43259562389245076 0.1441985402231207 2.663705713444869e-10 9.574513757762547 3.0187751604594317 VKEGMNIVEAMER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKEGMNIVEAMER 13 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 20656500.0 7402200.0 1622300.0 11632000.0 False True 7167221.212759427 2270092.850182736 8585230.247479955 1.0 0.316732633582093 1.1978464167111407 22.772982452599987 -6.699692812912368 1.83186277598885 0.5755877592096608 1.1952171282292734 0.4161226998750852 0.2884326050858752 0.39618534202569666 2.5844782546296243 0.12562001202786724 0.3231963472343341 1.9966741119464684e-07 6.699692812912368 0.6196293690196126 VKEGMNIVEAMER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKEGMNIVEAMER 13 1 P62937;P62937-2 P62937;P62937-2 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed 0 41182850.0 2540900.0 26224800.0 12417150.0 False True 3480339.395240632 25066101.62218347 9484474.909231652 1.0 7.202200353350995 2.725158047000152 21.730796570787625 -6.561898567184337 2.3384252812076345 5.26828073519682 2.732534045239868 0.0 2.706663376233022 0.7553445892217208 7.742737469253729 0.9832982672808093 3.043295754584136 2.7422145624376366e-07 6.561898567184337 -2.5357466899569516 VKGDVDISLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKGDVDISLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 4146600.0 1047300.0 1753900.0 1345400.0 False True 1373020.442067627 1492224.9566486515 1206190.9139880936 1.0 1.0868191841350263 0.8784945052760428 20.388921674379507 -6.793495784646351 1.482179711677565 1.0483033823609964 0.8760554542592508 0.812502746949706 0.03699644238743887 0.23017611160374438 0.9988130945145178 0.019642719894518556 0.04587725236163295 1.6088079932420102e-07 6.793495784646351 -0.1722479281017456 VKGDVDISLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKGDVDISLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 13326700.0 1926600.0 9144800.0 2255300.0 False True 2922793.053326554 7512838.991351476 1809538.966466896 1.0 2.5704313833648937 0.6191129284392487 21.47891625289545 -6.6925200544236025 1.857734734545347 1.9822520250785498 0.6256991876434933 0.38210251581618726 0.6638496748392552 0.41128548190221587 2.753992606676439 0.28568128564041734 0.7415046317044803 2.0299247818246036e-07 6.6925200544236025 -1.3565528374350566 VKGDVDVSLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKGDVDVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 16396000.0 4058000.0 6229800.0 6108200.0 False True 5320077.297727895 5300338.123570205 5476182.057991729 1.0 0.9962896828273302 1.0293425737123225 22.343015776749617 -6.87901280592765 1.085233174754968 0.9977288063845452 1.031641642748417 0.9728827453407208 0.002434612389259195 0.12851080520970715 0.2775691821810541 0.0017295799441396278 0.004172474378396139 1.321256674062651e-07 6.87901280592765 0.03391283636387177 VKGDVDVSLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKGDVDVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 10670500.0 2990400.0 1279000.0 6401100.0 False True 2895471.388862204 1789711.3698968883 4724459.881116222 1.0 0.6181070815554383 1.631672099848561 21.465366810461788 -6.804627501057573 1.4369122445214575 0.7905129862586118 1.6473205909146518 0.8453570951166797 0.1643587876870549 0.2142180107819957 0.8726554705452952 0.08996483479974465 0.20866685570626012 1.5680954654392343e-07 6.804627501057573 0.85680760465604 VKGDVDVSLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKGDVDVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 41869200.0 4070800.0 31185000.0 6613400.0 False True 6175701.215343982 25619793.10048292 5306258.591243804 1.0 4.148483258359175 0.8592155621227296 22.558171525044038 -6.656097370723134 1.986753752584476 3.0331149241745 0.8730019407265003 0.21915448696135398 1.3418123895032823 0.49375678938981177 3.742333154317758 0.5464432515619858 1.4868941349453977 2.2075097441878553e-07 6.656097370723134 -2.1601129834479997 VKGDVDVSLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKGDVDVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 12969300.0 4058000.0 3477900.0 5433400.0 False True 5558352.263326566 3324234.8781226813 4150142.8243855718 1.0 0.5980612096242334 0.746649839335982 22.40622583827251 -10.252956313443386 4.784235094905575 1.000087371212466 0.672355524479471 0.8663630260650219 0.060661054064416575 5.65469998773953e-05 8.829613159075256e-06 0.05875042058059343 0.019578271012589743 5.585263752040972e-11 10.252956313443386 -0.32773184673299505 VKGDVDVSLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKGDVDVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 6296100.0 2990400.0 2193600.0 1112100.0 False True 2486650.097182116 2181782.641404493 1344634.9682305725 1.0 0.8773983295345411 0.540741526021019 21.245772085896064 -6.953421476985737 0.5199291215764971 1.0057238155602939 0.3973940842306283 0.9994431423060494 0.004581780999447999 0.08214029672878205 0.030496682441697325 0.00519115714161679 0.027807825209658583 1.113213650227499e-07 6.953421476985737 -0.6083297313296656 VKGDVDVSLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKGDVDVSLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 18003900.0 4070800.0 9399100.0 4534000.0 False True 5269730.847464492 8876031.82252708 3708858.5227686265 1.0 1.6843425365448683 0.7038041657389633 22.329297847136488 -6.719051788500808 1.7627240929367904 1.4167640676216369 0.7054125127345505 0.5080536489361928 0.288007441573362 0.35715638792453197 2.1683098757650097 0.12975815010622652 0.32610572817436745 1.9096255270520427e-07 6.719051788500808 -0.7113515548870863 VKGDVDVSVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKGDVDVSVPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9412100.0 2438500.0 3657100.0 3316500.0 False True 3196897.114467592 3111474.935264147 2973340.394114397 1.0 0.9732796595746338 0.9300707178402813 21.608240884028827 -6.963986356253564 0.3751786006297474 1.0031337420295114 0.8987006261568018 0.9998904660914159 0.00030148486819939576 0.07830823837056926 0.016093198772920973 0.0005654347133816504 0.003659748725698639 1.086459755177995e-07 6.963986356253564 -0.10443311587270965 VKGDVDVSVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKGDVDVSVPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7477000.0 1944900.0 1089000.0 4443100.0 False True 1883160.2140844373 1523843.3790599771 3279318.819857138 1.0 0.8091947608402749 1.7413913034752018 20.84472431501845 -6.853369066772441 1.2186642805434467 0.8978034679118594 1.7811631093411917 0.945073526684352 0.09423446498746961 0.1537892391947557 0.43781674551093624 0.06044978576262298 0.14022467672728808 1.4016220891400053e-07 6.853369066772441 0.8833596414293323 VKGDVDVSVPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKGDVDVSVPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 31439200.0 2208200.0 25156000.0 4075000.0 False True 3350000.8410441657 20666715.255274918 3269574.4638640475 1.0 6.169167184099359 0.9759921322422564 21.675730027094612 -6.6472313573986614 2.0183664461742925 4.361578329634753 0.9977609394690086 0.1829395078191982 2.207762139443058 0.5153327540630794 4.020749699595319 0.8880742733956224 2.445188138734679 2.25303865342924e-07 6.6472313573986614 -3.363817390165744 VKGDVDVSVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKGDVDVSVPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9464900.0 2438500.0 3410600.0 3615800.0 False True 3340079.3479846837 3259908.4146540277 2761822.5097385347 1.0 0.9759972967770874 0.8268733230559167 21.67145094555172 -6.935105213869043 0.7036583910089602 1.0018964360305769 0.7918615192267708 0.9974493859507095 0.003867798688448457 0.09007294200610544 0.06532810460018217 0.0036376283512010586 0.01313518014182694 1.1611672708662557e-07 6.935105213869043 -0.21003491680380604 VKGDVDVSVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKGDVDVSVPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 4321980.0 1944900.0 1594400.0 782680.0 False True 1617270.5236789389 1585810.6507363787 946334.7692965594 1.0 0.9805475506528148 0.5851431504136076 20.625129590452726 -6.917133653491899 0.8457086969972779 1.009657792778234 0.5254020743784868 0.9933470302206567 0.01559091872185296 0.09988792574928833 0.11456889325043186 0.013233125832252947 0.03861576690227597 1.2102256310661767e-07 6.917133653491899 -0.4842557183997471 VKGDVDVSVPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKGDVDVSVPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9562400.0 2208200.0 4775900.0 2578300.0 False True 2858558.4301294824 4510116.966646494 2109075.855592047 1.0 1.5777592366520918 0.7378110005946296 21.446856349187062 -6.7216262692027025 1.7537055734530713 1.3508931270043998 0.7390204620512326 0.5200883107979084 0.2430756243081524 0.35215932638151737 2.1175637258866464 0.11002462960487339 0.2756508445907815 1.8983388282265015e-07 6.7216262692027025 -0.6118726649531672 VKGDVDVTLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKGDVDVTLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5472100.0 2073500.0 1541600.0 1857000.0 False True 2718378.579802564 1311599.2891097341 1664855.4536018202 1.0 0.4824932402185849 0.6124442952764654 21.37431495889892 -10.153959828198817 7.875639283957983 1.0000000982972446 0.5474687677475788 0.9417546139053229 0.05305229607135503 9.159061284976279e-08 9.81625175312324e-09 0.051367676272009916 0.017122554930201934 7.01520185327941e-11 10.153959828198817 -0.45253133054966577 VKGDVDVTLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKGDVDVTLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 3873020.0 937020.0 689700.0 2246300.0 False True 907274.812998817 965100.8067379846 1657926.6424444842 1.0 1.0637359187212916 1.8273698538643837 19.79118008285217 -6.923415701256564 0.798979736907153 0.9851338770592951 1.960739164269118 0.9950784741215776 0.026371071427803067 0.09620335896815203 0.09550204186327957 0.023142567034667622 0.0717588049216599 1.1928457807520417e-07 6.923415701256564 0.975605287209823 VKGDVDVTLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKGDVDVTLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 19619000.0 2469500.0 13730000.0 3419500.0 False True 3746412.0446329867 11279774.227020372 2743634.3261799053 1.0 3.010820511101945 0.7323365111721668 21.837078150714326 -6.67373187273925 1.9237928769094297 2.279398459443193 0.7413356994626509 0.29563867729287285 0.8534349767913922 0.4527262193123974 3.2336201854605493 0.35665899358242403 0.9484121065617069 2.1196693852098553e-07 6.67373187273925 -1.538062759980542 VKGDVDVTLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKGDVDVTLPK 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 6265400.0 2073500.0 1207200.0 2984700.0 False True 2840128.9842305686 1153861.9123234437 2279775.331826038 1.0 0.4062709541468383 0.8027013366238582 21.437525020421813 -10.110723641356584 5.650053984146714 1.0000037385420335 0.6044861453853336 0.570294502654694 0.16184202593437033 7.621785395897781e-06 1.1993614516591235e-06 0.156704350179091 0.052234289263329216 7.749547751088968e-11 10.110723641356584 -0.3955175931566999 VKGGVDVTLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKGGVDVTLPR 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 5624400.0 1158500.0 2859300.0 1606600.0 False True 1757529.1976948038 2349035.575187131 1289054.8058022049 1.0 1.3365556477059692 0.733447164060173 20.745117226200705 -6.755288219341672 1.6304516703553062 1.196637182260369 0.7317620061514646 0.6713154004289499 0.1414758985170798 0.2909204418914409 1.5231243196214381 0.06850389921931092 0.1653846058352961 1.75675735576257e-07 6.755288219341672 -0.4648751761089044 VKGGVDVTLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKGGVDVTLPR 11 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 4414900.0 1158500.0 1725600.0 1530800.0 False True 1499701.0874490559 1629568.8430756917 1252210.107334409 1.0 1.0865957601241303 0.834973127521284 20.516243548293154 -6.813773811263343 1.3984502352275328 1.0469878969350788 0.83017350451942 0.8694982035707374 0.03770538254565683 0.20169287925791246 0.7766390492513633 0.02119551347906216 0.04895494592501735 1.5354164483653198e-07 6.813773811263343 -0.2168143924156588 VKNFGIWLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKNFGIWLR 9 1 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 17156900.0 12147000.0 1498800.0 3511100.0 False True 15924834.631715322 1275184.8822766403 3147805.052849412 1.0 0.08007523542737634 0.19766642013226046 23.924775055390572 -10.44664130857152 5.902388218210355 1.0004665846867644 0.13887082777999973 0.9862075154805007 0.04800640012939057 0.0002949014205346008 2.7647463121985085e-05 0.04650529676923845 0.01549399901770808 3.575680379427289e-11 10.44664130857152 -0.8615957569067647 VKNFGIWLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKNFGIWLR 9 1 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 10959600.0 2190900.0 0.0 8768700.0 False True 3323755.476244755 0.0 7035562.601542256 1.0 0.0 2.116750961924303 21.664382818404377 -6.778232069787236 1.5426768566374771 0.4324753572973218 2.1326220153250617 0.761109443950002 0.42258465055691663 0.2533324938470577 1.190695171918075 0.21577620050368768 0.5099162465213334 1.6663565396006597e-07 6.778232069787236 1.70014665802774 VKNFGIWLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKNFGIWLR 9 1 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 29381000.0 12147000.0 14231000.0 3003000.0 False True 16638074.160332141 13602227.364376172 2293753.24872637 1.0 0.817536166343463 0.13786170362162758 23.987985116913464 -7.072433605687939 0.6648960613740242 1.0018999619745965 6.452655012767173e-24 0.9982517309329639 0.015510886506904766 0.07612676268890399 0.05352305436586866 0.015250964505016399 0.04956658102343363 8.463819525653886e-08 7.072433605687939 -1.0018999619745965 down VKNFGIWLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKNFGIWLR 9 1 Q02543;M0R3D6;M0R1A7;M0R117;M0R0P7 Q02543 RPL18A 60S ribosomal protein L18a 0 19131100.0 2190900.0 5209200.0 11731000.0 False True 2836163.2390955025 4919303.440745183 9596078.370224696 1.0 1.734492349711869 3.383471810771032 21.435509140496826 -6.957722942271415 0.4664177008186671 0.9548948970293731 4.230263159551183 0.9996762034364975 0.017933814482771777 0.08052477398276962 0.024214330689109064 0.022649350832088324 0.1361374835797444 1.1022422596370165e-07 6.957722942271415 3.27536826252181 VKPAPDETSFSEALLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKPAPDETSFSEALLKR 17 2 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 1 32360100.0 10511600.0 4416000.0 17432500.0 True False 10177915.01175894 6179331.829135772 12866405.286209978 1.0 0.6071314038284413 1.2641494128556705 23.27893871381026 -6.744774466270583 1.669325165671181 0.7675405083248777 1.264939759531471 0.6260923990244439 0.16506096625293376 0.3092660480745496 1.6939081125369824 0.0781691651393323 0.1908159732829674 1.7998053304739237e-07 6.744774466270583 0.49739925120659334 VKPAPDETSFSEALLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKPAPDETSFSEALLKR 17 2 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 1 235756800.0 13584800.0 34990000.0 187182000.0 True False 20609134.781911425 28745761.121882234 150185395.65521497 1.0 1.3948067896141036 7.287321726239193 24.29678060275938 -6.920486228015578 0.8211116081642768 0.8722498706264169 8.24825474443925 0.994314921937798 0.2167987794988367 0.09788661967488238 0.10413776478318941 0.18727659510024736 0.5636174043007136 1.2009191549575687e-07 6.920486228015578 7.376004873812834 up VKPAPDETSFSEALLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKPAPDETSFSEALLKR 17 2 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 1 32815700.0 10511600.0 7060800.0 15243300.0 True False 8740861.142836919 7022762.068940931 18430603.55294404 1.0 0.8034405253875976 2.1085569547169625 23.059343989244535 -6.868542912131023 1.1418459517426471 0.8897656882288258 2.182881152053232 0.9632035215400958 0.11021055488912916 0.1382558709464881 0.3378239564869818 0.0749742311698363 0.17706030875443354 1.3534963466692621e-07 6.868542912131023 1.293115463824406 up VKPAPDETSFSEALLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKPAPDETSFSEALLKR 17 2 Q12905;B4DY09;X6R6Z1;A0A0A0MRL0 Q12905 ILF2 Interleukin enhancer-binding factor 2 1 183504800.0 13584800.0 29689000.0 140231000.0 True False 17585791.396441907 28036781.05127151 114710396.89156744 1.0 1.5942860016492706 6.522902171737152 24.06790692485183 -6.929431791006681 0.751440160922242 0.9234483007071795 7.52023897295355 0.996425386991529 0.14799728227743925 0.09293406621748831 0.07913317211183632 0.13437945397121112 0.44735681440601305 1.1764357376568235e-07 6.929431791006681 6.59679067224637 up VKPFMTGAAEQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKPFMTGAAEQIK 13 1 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;E9PJF7;Q56UQ5 P13693 TPT1 Translationally-controlled tumor protein;TPT1-like protein 0 17136300.0 1853500.0 8847100.0 6435700.0 False True 2429956.4493195317 7527147.16572569 5769795.499593557 1.0 3.0976469425341104 2.374443995162667 21.212499026812115 -10.188660907621664 5.516592982366103 0.9999419591783224 2.7360454688485585 0.8848347118142947 0.2952463669234167 0.00021076853865240202 3.099741960705932e-05 0.2858804661308691 0.09529035517679967 6.476480949309377e-11 10.188660907621664 1.7361035096702362 VKPFMTGAAEQIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKPFMTGAAEQIK 13 1 P13693;Q5W0H4;A0A0B4J2C3;J3KPG2;P13693-2;E9PJF7;Q56UQ5 P13693 TPT1 Translationally-controlled tumor protein;TPT1-like protein 0 15474700.0 1853500.0 7065100.0 6556100.0 False True 2538789.038954114 6752940.520838607 5007684.207117872 1.0 2.6599061273797546 1.9724696027444841 21.275709088335006 -10.491201940784384 5.85409885641333 0.9986171860716824 2.31618786506212 0.8301559328069511 0.2806447859847699 0.0050685837180659546 0.00044052614562033627 0.2719234600651794 0.09057771519324624 3.2269932666274165e-11 10.491201940784384 1.3175706789904376 VKPYLPQICGTVLWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VKPYLPQICGTVLWR 15 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 40778000.0 9233000.0 19373000.0 12172000.0 False True 12104552.412499178 16482623.91536254 10912558.202068586 1.0 1.3616880123830568 0.9015251312225525 23.529046398302107 -6.697124668068759 1.841282278609416 1.2252289120967115 0.9029737359506599 0.4038345384342269 0.15275560067919902 0.40155392203226986 2.6447309132583383 0.06623841394374995 0.17094489189090745 2.0085161675326165e-07 6.697124668068759 -0.3222551761460516 VKPYLPQICGTVLWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VKPYLPQICGTVLWR 15 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 21541600.0 12216000.0 4553800.0 4771800.0 False True 11828209.766700327 6372156.087753285 3521922.4290685025 1.0 0.5387253196753968 0.2977561692373503 23.495728398400843 -9.617791844666185 0.17173284744261444 1.5783089439288278 1.5996639071009864e-21 0.9996592069671653 0.005378569607172736 1.0642950025771885 0.07042982931453692 0.4686133542956587 0.16780690826206957 2.411060762048346e-10 9.617791844666185 -1.5783089439288278 VKPYLPQICGTVLWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKPYLPQICGTVLWR 15 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 184778000.0 49137000.0 54782000.0 80859000.0 False True 74544421.39588225 45005724.086280435 64877183.20824127 1.0 0.6037436905877775 0.8703157391711275 26.151597055276437 -10.159749240612276 5.31043578314051 1.0000090742077206 0.7370297148793485 0.5647530626108115 0.1088275831199669 1.1692164065859645e-05 1.850018144518566e-06 0.10537548873975887 0.03512395141925036 6.922305458886243e-11 10.159749240612276 -0.262979359328372 VKPYLPQICGTVLWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VKPYLPQICGTVLWR 15 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 64485000.0 9233000.0 26151000.0 29101000.0 False True 12646689.612443121 24995562.350207403 22227943.153908156 1.0 1.976451001502732 1.757609606551742 23.592256459825 -10.126098288406736 5.620217596314355 0.9999893722517706 1.8670303040273473 0.9543982715415029 0.08934162537186667 1.1899486997214474e-05 1.8504741135997295e-06 0.08650571728657534 0.028834885598970628 7.480001958789699e-11 10.126098288406736 0.8670409317755766 VKPYLPQICGTVLWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VKPYLPQICGTVLWR 15 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 29929900.0 12216000.0 2676900.0 15037000.0 False True 10158145.26055936 2662479.0083769495 18181167.176767442 1.0 0.2621028681992228 1.789811694006657 23.27613367383512 -6.775354119879833 1.5537080646852548 0.5796503505674009 1.8002455841541938 0.7506498427178366 0.31149663172459247 0.257887288181338 1.2292194762654747 0.15795268494655204 0.37421609320837473 1.6774356941082548e-07 6.775354119879833 1.220595233586793 VKPYLPQICGTVLWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKPYLPQICGTVLWR 15 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 0 151176000.0 49137000.0 47966000.0 54073000.0 False True 63608815.1350749 45296649.93449729 44232268.835833184 1.0 0.7121127761664594 0.6953795435727715 25.922723377368886 -13.999999999999996 0.4050286669218985 6.012458726550389 0.6945120796489516 0.9998447554049885 0.0017421379636232746 27.527589149032277 0.21035394232009685 121.48610376818567 0.004223191148378459 1.0000000000000082e-14 13.999999999999996 -5.317946646901437 VKRDLVLSGDLGSLYAMTQDK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 VKRDLVLSGDLGSLYAMTQDK 21 2 E2PU09;O15031 E2PU09 PLXNB2 Plexin-B2 1 78622000.0 15581000.0 38727000.0 24314000.0 True False 23637516.123679522 31815864.274567936 19508327.242795248 1.0 1.3459901669911727 0.8253120649699844 24.49457510648153 -6.727571696859049 1.732213290258092 1.2087764272190464 0.8257634832436835 0.5479362435704138 0.14547560474891646 0.34079842725711895 2.0022260810336605 0.06658575610178553 0.16567607066450932 1.872527925386409e-07 6.727571696859049 -0.3830129439753629 VKRDLVLSGDLGSLYAMTQDK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VKRDLVLSGDLGSLYAMTQDK 21 2 E2PU09;O15031 E2PU09 PLXNB2 Plexin-B2 1 53343000.0 15581000.0 25561000.0 12201000.0 True False 20169911.647426613 24138507.880075175 9980543.192831947 1.0 1.196758235832674 0.49482334713673964 24.26570142857398 -6.83186822712222 1.3194636288451371 1.105007742072489 0.4751932636416854 0.9095729068816156 0.08890234948367413 0.17851758860493655 0.6071615562324039 0.052890586359452485 0.12171882207873769 1.472759296715673e-07 6.83186822712222 -0.6298144784308037 down VLAAVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLAAVYK 7 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;A0A087WXX2;A0A3B3IS80;P05062;P09972 P04075;P09972 ALDOA;ALDOB;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase B;Fructose-bisphosphate aldolase C 0 44837000.0 15053000.0 15420000.0 14364000.0 False True 19734628.77345935 13119396.106689226 12877751.069217326 1.0 0.6647906204515588 0.6525458987369612 24.234226045275516 VLAAVYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLAAVYK 7 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;A0A087WXX2;A0A3B3IS80;P05062;P09972 P04075;P09972 ALDOA;ALDOB;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase B;Fructose-bisphosphate aldolase C 0 30106300.0 14480000.0 5005300.0 10621000.0 False True 14020340.325951269 7003942.3922946835 7839041.476829823 1.0 0.4995558045998767 0.5591192007172586 23.74101803357456 -10.159908448573798 5.279338832844461 1.0000172815083002 0.5293375026593153 0.9881309622877095 0.02431665463990298 4.946307366868833e-06 7.870886362337408e-07 0.023545363037484054 0.007848166537875524 6.9197682768475e-11 10.159908448573798 -0.4706797788489848 VLAAVYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLAAVYK 7 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;A0A087WXX2;A0A3B3IS80;P05062;P09972 P04075;P09972 ALDOA;ALDOB;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase B;Fructose-bisphosphate aldolase C 0 215693000.0 21872000.0 177370000.0 16451000.0 False True 33181423.057385188 145716937.70186466 13199452.639270544 1.0 4.391521649021995 0.3977964602796848 24.983872424941943 -6.68170982490543 1.8957680794465988 3.142567212647072 0.41278646260500335 0.33195832779640133 1.4368761786669686 0.43475278155622393 3.0223349536039925 0.6078431201933048 1.5996683105809584 2.0810867066873796e-07 6.68170982490543 -2.7297807500420688 VLAAVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLAAVYK 7 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;A0A087WXX2;A0A3B3IS80;P05062;P09972 P04075;P09972 ALDOA;ALDOB;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase B;Fructose-bisphosphate aldolase C 0 52012000.0 15053000.0 18461000.0 18498000.0 False True 20618500.89202928 17645331.977636743 14129153.378268545 1.0 0.8558009173430301 0.6852657936800152 24.297436106798408 -6.968906462609393 0.28309022236694564 1.0361989924447184 0.4996490937903282 0.9999725495344682 0.0006739589793879302 0.07665916191718619 0.010294460348001131 0.003094961096804825 0.01559285203281809 1.0742207507311222e-07 6.968906462609393 -0.5365498986543902 VLAAVYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLAAVYK 7 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;A0A087WXX2;A0A3B3IS80;P05062;P09972 P04075;P09972 ALDOA;ALDOB;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase B;Fructose-bisphosphate aldolase C 0 24055100.0 14480000.0 7084700.0 2490400.0 False True 12040761.572765185 7046533.314897162 3011131.125691407 1.0 0.5852232246534644 0.2500781289866447 23.521423309008835 -7.84378136813614 0.2835208218734709 1.1264763805201512 1.0295505159811594e-17 0.9994882455438467 0.006938821030156382 0.115989436684679 0.04601486089125112 0.047459558812708275 0.08570224258955196 1.4329090706256339e-08 7.84378136813614 -1.1264763805201512 down VLAAVYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLAAVYK 7 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;A0A087WXX2;A0A3B3IS80;P05062;P09972 P04075;P09972 ALDOA;ALDOB;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase B;Fructose-bisphosphate aldolase C 0 68500000.0 21872000.0 25043000.0 21585000.0 False True 28313735.161575954 23649335.035433754 17656751.480803013 1.0 0.8352601626198661 0.6236108157416357 24.754998747034392 -6.967703400114276 0.30814656203232454 1.0333282876670635 0.41883298257371143 0.9999585199745521 0.0009921904901667572 0.07705517770194842 0.011683888342418146 0.003377142905929536 0.0188244833540828 1.0772006328508277e-07 6.967703400114276 -0.6144953050933522 VLAELYVSDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLAELYVSDR 10 0 O43776;K7EIU7;K7EQ35;O43776-2;K7EJ19 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 5441200.0 2127900.0 1358000.0 1955300.0 False True 2060350.9792535708 1900256.481876444 1443148.2722573562 1.0 0.9222974633986263 0.7004380742839182 20.974458689692593 -6.952556848553815 0.5300298754792816 1.0034983059879743 0.6091651530478596 0.9993869658208342 0.0031426737404667508 0.08247498352943201 0.031836700754015373 0.0035059659799597637 0.018346662706227177 1.1154321332533052e-07 6.952556848553815 -0.39433315294011473 VLAFGAKPDSTLHTYFPSFLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLAFGAKPDSTLHTYFPSFLSR 22 1 Q6NUQ4-2;Q6NUQ4;H7C085;H7C0H8 Q6NUQ4-2 TMEM214 Transmembrane protein 214 0 11423000.0 5502200.0 2950100.0 2970700.0 False True 4575323.088789265 2934207.225750995 3591859.6350351213 1.0 0.6413114809182696 0.7850504904967508 22.12544219296917 -10.072229514260838 5.021533090937425 1.0000062918410124 0.713180986546844 0.8414939990044313 0.05868120493798391 4.133566374118788e-06 7.636420186191324e-07 0.05681907834438412 0.018939277454357736 8.467797929766759e-11 10.072229514260838 -0.2868253052941684 VLAFLSSVAGDALTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLAFLSSVAGDALTR 15 0 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 4242390.0 936590.0 632800.0 2673000.0 False True 1282872.633393058 604840.8036102348 2041692.4521630316 1.0 0.47147377523402056 1.5915005114443652 20.290946512710825 -6.778411677547116 1.5423288843860636 0.700115238559173 1.5998927206554643 0.7616367983838717 0.22335777452004307 0.25305149408928845 1.1889075864659546 0.11408140078949036 0.269513554427963 1.6656675400885437e-07 6.778411677547116 0.8997774820962913 VLAFLSSVAGDALTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLAFLSSVAGDALTR 15 0 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 3060570.0 1364300.0 695270.0 1001000.0 False True 1134475.8987378147 691524.4425097111 1210304.4718989322 1.0 0.6095541062433159 1.0668401798975917 20.1135945294664 -6.680592912241568 1.8997293146555467 0.7530920269917185 1.0651096365017818 0.32685257594967354 0.16545881186203212 0.4372132667989866 3.0511938498468822 0.06987275739386782 0.18414832076054807 2.0864457054273125e-07 6.680592912241568 0.3120176095100633 VLAFLVLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLAFLVLSR 9 0 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 0 4562200.0 1073600.0 1720900.0 1767700.0 False True 1407499.9967571895 1464148.4280156607 1584795.360975733 1.0 1.040247553384715 1.1259647350813664 20.42470348830578 -6.958797432957996 0.45206895961920335 0.9972935096255264 1.1723285963536094 0.9997229349595974 0.0008743536250552596 0.08013360435820595 0.022740496385118603 0.0011492851880041243 0.007088099309795306 1.0995185659303823e-07 6.958797432957996 0.175035086728083 VLAFLVLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLAFLVLSR 9 0 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 0 7274000.0 1073600.0 2663300.0 3537100.0 False True 1470538.9329490901 2545626.599644657 2701709.8288611537 1.0 1.7310841233829384 1.837224277661941 20.487913549828672 -11.197353991235579 0.3446931123401988 4.849868139451896e-10 1.8558843024861589 0.9994161678242006 0.008992959583063115 3.22375472666495 0.17484492225827045 2.516989354329994 0.03217930980183371 6.348132878158126e-12 11.197353991235579 1.8558843020011722 VLAGETLSVNDPPDVLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLAGETLSVNDPPDVLDR 18 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7EQR9 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 10500900.0 1801700.0 3788300.0 4910900.0 False True 2362046.1476876177 3223100.4066777457 4402767.176679157 1.0 1.3645374413336835 1.8639632341600745 21.171605720507046 -6.966719596362778 0.32719802819628097 0.9371314833413009 2.307650430771293 0.9999443300141965 0.0026423260277293813 0.07738217658185123 0.012827885475545633 0.0073619533302590814 0.043660828717222426 1.0796435726091674e-07 6.966719596362778 1.3705189474299921 VLAGETLSVNDPPDVLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLAGETLSVNDPPDVLDR 18 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7EQR9 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 25737600.0 8755600.0 2126000.0 14856000.0 False True 8477658.270573128 2974922.8869435387 10964767.92955314 1.0 0.35091328194600846 1.293372247335451 23.015234382699273 -6.7214046721297205 1.7544649879649168 0.605693288867735 1.2919998257518286 0.5190543801793486 0.27309184320833924 0.3525916657690602 2.12187530007829 0.12356206449292315 0.3096517922539604 1.8993076954015e-07 6.7214046721297205 0.6863065368840936 VLAGETLSVNDPPDVLDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLAGETLSVNDPPDVLDR 18 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7EQR9 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 9317400.0 1801700.0 3953600.0 3562100.0 False True 2467837.179111749 3778916.879193149 2720805.343752319 1.0 1.5312666942449171 1.1025060189471743 21.234815782029937 -10.190115199897116 6.230373462411148 0.9999971488964887 1.3168863565960465 0.42139990125385196 0.17504081270843788 6.932370855704177e-06 9.011109621207452e-07 0.16948406325166201 0.056494179377198875 6.454829870781204e-11 10.190115199897116 0.31688920769955775 VLAGETLSVNDPPDVLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLAGETLSVNDPPDVLDR 18 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5;K7EKJ9;K7EQR9 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 13457500.0 8755600.0 2758200.0 1943700.0 False True 7280669.33884688 2743341.0291401674 2350118.6833466077 1.0 0.3767979153376385 0.3227888225615836 22.79563965813355 -13.999999999999998 0.346314374815555 8.492064742182441 0.3149588866555991 0.9997476246052843 0.004881902842440593 20.298292484156377 0.18918196529918746 111.67647441493719 0.016319973357226195 1.0000000000000041e-14 13.999999999999998 -8.177105855526841 VLAGLYMGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLAGLYMGR 9 0 Q92616 Q92616 GCN1L1 Translational activator GCN1 0 4548000.0 1252700.0 1230000.0 2065300.0 False True 1642301.8311640562 1046488.7945024488 1851602.567756511 1.0 0.6372085658339077 1.1274435262877978 20.647287867150247 -6.708505911584366 1.8007126487782354 0.7766179027685801 1.1262313550096597 0.45787383151655026 0.1529153161732544 0.37811069608247394 2.389075276187666 0.06760450692930964 0.17204741225336648 1.9565641351473814e-07 6.708505911584366 0.34961345224107954 VLAIGDEK(ub)DQTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLAIGDEKDQTR 12 1 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 6003400.0 1651100.0 1869300.0 2483000.0 True False 2164608.0892751426 1590407.7264743317 2226082.9786178386 1.0 0.73473241385091 1.028400009058121 21.04567441236358 -6.668783251459942 1.9413487182449054 0.830500423720059 1.0272130487560083 0.27365530781494585 0.11271246734114251 0.46401673864106163 3.3702506991853998 0.04675603036942862 0.1251343169024723 2.1439603460784707e-07 6.668783251459942 0.19671262503594933 VLAIGDEK(ub)DQTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLAIGDEKDQTR 12 1 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 18509100.0 4461900.0 3796200.0 10251000.0 True False 6769028.508583905 3118738.4501540205 8224885.356827084 1.0 0.4607364921272088 1.2150761880226957 22.690517362294333 -6.714782972125717 1.7778719492853938 0.670098294756342 1.2135836855083162 0.48780193057321586 0.2270825110238897 0.3655993311438861 2.255391789105919 0.1015270934478253 0.25646901431137453 1.9284883865795135e-07 6.714782972125717 0.5434853907519742 VLAIGDEK(ub)DQTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLAIGDEKDQTR 12 1 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 5831400.0 1651100.0 1597200.0 2583100.0 True False 2261556.289299777 1526630.42276591 1973024.9806144137 1.0 0.6750353418081781 0.8724191345355821 21.108884473886473 -10.307181388448699 5.674897605661295 1.0000264823481924 0.773727239491967 0.6366525203237232 0.08058159594624362 2.7002506096771272e-05 3.296554438959096e-06 0.07803191747855352 0.02600759825921695 4.9296786684001025e-11 10.307181388448699 -0.22629924285622538 VLAIGDEK(ub)DQTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLAIGDEKDQTR 12 1 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 6585200.0 1345500.0 2890500.0 2349200.0 True False 1118842.865756599 2874928.302780672 2840406.8585264445 1.0 2.569555020433141 2.5387004247514833 20.093576002678684 -10.083951880230403 4.485749285398929 0.999880691315828 2.5541277226608377 0.9997044715365273 0.012596336256989719 2188551.640506863 0.7047370670845517 2732.3211581835553 0.004312060896130998 8.242294344631862e-11 10.083951880230403 1.5542470313450096 VLAIGDEK(ub)DQTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLAIGDEKDQTR 12 1 Q12789;Q12789-3 Q12789 GTF3C1 General transcription factor 3C polypeptide 1 1 24856700.0 4461900.0 5481500.0 14913300.0 True False 5776017.507198058 5176449.70637424 12199232.423380084 1.0 0.8961970250130582 2.11204907328924 22.461643684386782 -6.886142730549787 1.0449777481769429 0.9285024590748607 2.209032780437557 0.9783105791576288 0.08104825953898002 0.1223266209002903 0.24060052926273975 0.05937747983403129 0.14610961158837588 1.2997423485026424e-07 6.886142730549787 1.2805303213626962 up VLAINILGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLAINILGR 9 0 O43747;O43747-2 O43747 AP1G1 AP-1 complex subunit gamma-1 0 18122200.0 5885900.0 5921900.0 6314400.0 False True 7716471.89913668 5038375.603385405 5661046.460001804 1.0 0.6529377245511772 0.7336314489313649 22.87950994310603 -10.416371346144436 6.622114660867221 1.0000418677609446 0.6932845867412726 0.9506496660426798 0.03294307502937379 2.036579561651031e-05 1.794935939121402e-06 0.03190133635169542 0.010632331746802169 3.833792945009706e-11 10.416371346144436 -0.30675728101967203 VLAINILGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLAINILGR 9 0 O43747;O43747-2 O43747 AP1G1 AP-1 complex subunit gamma-1 0 16443000.0 6763900.0 5486400.0 4192700.0 False True 6549183.6968716765 7677148.131198043 3094506.0916961147 1.0 1.1722297749664827 0.4725025644301679 22.642883666834415 -6.841608279564057 1.2749913134074278 1.091608825720988 0.4487578466464855 0.9271706817687303 0.08033534999754101 0.16692920998258345 0.526437453781477 0.04939458074360413 0.11384374337403125 1.4400969163290992e-07 6.841608279564057 -0.6428509790745025 down VLAINILGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLAINILGR 9 0 O43747;O43747-2 O43747 AP1G1 AP-1 complex subunit gamma-1 0 43118000.0 12116000.0 16179000.0 14823000.0 False True 18380857.798247952 13291731.042896032 11893227.552848315 1.0 0.7231289849901885 0.6470442067171625 24.131700760131256 -13.999999999999998 0.1812480229311238 2.4421039261799358 0.5873784898889224 0.9994966851416276 0.003402582000410824 12.221108007187055 0.1349704003864823 6.208411264997988 0.05621065261909969 1.0000000000000041e-14 13.999999999999998 -1.8547254362910133 VLAINILGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLAINILGR 9 0 O43747;O43747-2 O43747 AP1G1 AP-1 complex subunit gamma-1 0 30338000.0 5885900.0 8952100.0 15500000.0 False True 8062076.290466698 8556566.621364074 11839219.232520407 1.0 1.0613353574292153 1.4685074670553704 22.94272000462892 -6.933734089166633 0.715473039486758 0.9945833185793953 1.5606457447960111 0.9972226868327408 0.01095706012076958 0.09074455225133604 0.0685167641936435 0.010214244489803783 0.036115434011560046 1.1648390214516255e-07 6.933734089166633 0.5660624262166158 VLAINILGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLAINILGR 9 0 O43747;O43747-2 O43747 AP1G1 AP-1 complex subunit gamma-1 0 14376800.0 6763900.0 3105200.0 4507700.0 False True 5624482.541576417 3088471.6712660575 5450239.228750062 1.0 0.5491121447059248 0.9690205611737007 22.42328894226869 -10.525168730205754 9.140128333615001 1.0000110123171893 0.7590663529398128 0.3050534249239568 0.17142689317435733 3.847087379699434e-05 1.9985848119165382e-06 0.16599095268047168 0.05532779186303031 2.9842229763140843e-11 10.525168730205754 -0.2409446593773764 VLAINILGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLAINILGR 9 0 O43747;O43747-2 O43747 AP1G1 AP-1 complex subunit gamma-1 0 42086000.0 12116000.0 16132000.0 13838000.0 False True 15684400.842065403 15234240.018832307 11319625.989870366 1.0 0.97129881926852 0.7217123627388586 23.902827082223705 -6.928577716963498 0.7583749825243431 1.0040025145003717 0.6722811526859918 0.9962512590638992 0.007651630897689184 0.09338314802436432 0.08134747460199114 0.006912912290404581 0.02276246229757849 1.1787515668685302e-07 6.928577716963498 -0.33172136181437994 VLALSVETDYTFPLAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLALSVETDYTFPLAEK 17 0 P05388;F8VWS0;P05388-2;F8VW21;F8VZS0;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 0 367920000.0 103450000.0 143470000.0 121000000.0 False True 156941213.20805135 117866657.56377378 97084296.96381612 1.0 0.7510242539512051 0.6186029467932999 27.225649016970618 -13.99999999542066 0.07857767114562385 2.3544066787167734 0.21254439549014909 0.9998924860881201 0.0016394119543994478 12.272710205592563 0.07845657681900127 2.9085277736788364 0.36943353807740764 1.000000010544319e-14 13.99999999542066 -2.1418622832266245 VLALSVETDYTFPLAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLALSVETDYTFPLAEK 17 0 P05388;F8VWS0;P05388-2;F8VW21;F8VZS0;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 0 232691000.0 103450000.0 49042000.0 80199000.0 False True 133918064.30436328 46312769.588617325 65603604.911230944 1.0 0.3458291443293239 0.48987868255121925 26.996775339063067 -10.052344754393436 7.488436255362856 1.0000000466204189 0.4178539134426437 0.9560942161742422 0.058807977721197766 4.574819711820298e-08 5.778579737261446e-09 0.056940584675431345 0.018980193194861304 8.864520436906576e-11 10.052344754393436 -0.5821461331777751 VLALSVETDYTFPLAEKVK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLALSVETDYTFPLAEKVK 19 1 P05388;F8VWS0;P05388-2;F8VZS0;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 1 108849000.0 28354000.0 34347000.0 46148000.0 True False 43015090.95506127 28217509.495664116 37026827.572613105 1.0 0.6559909294424953 0.860786918044548 25.358339552549914 -10.279409115444512 5.543546908698587 1.000024461746961 0.7583889237435152 0.6498345594376468 0.0836076122406676 2.5279390731738102e-05 3.2860272404772528e-06 0.08096091063603904 0.0269842408186861 5.255219792848035e-11 10.279409115444512 -0.24163553800344573 VLALSVETDYTFPLAEKVK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLALSVETDYTFPLAEKVK 19 1 P05388;F8VWS0;P05388-2;F8VZS0;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 1 22041400.0 5676400.0 6081000.0 10284000.0 True False 4720178.107157755 6048240.4460160015 12434336.85215644 1.0 1.2813585226464974 2.634293996936431 22.170409867357336 -6.940679607141591 0.6532092647115669 0.9849735809215665 3.0065507811574466 0.9982515821419186 0.02983035734689371 0.08745793213301144 0.053207754514388056 0.02918939201068493 0.11610016688168295 1.1463583345906594e-07 6.940679607141591 2.02157720023588 up VLALSVETDYTFPLAEKVK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLALSVETDYTFPLAEKVK 19 1 P05388;F8VWS0;P05388-2;F8VZS0;F8W1K8 P05388 RPLP0 60S acidic ribosomal protein P0 1 98010000.0 28354000.0 35108000.0 34548000.0 True False 36704811.94089819 33154208.93758768 28260618.49241517 1.0 0.90326600749167 0.7699431490868338 25.129465874642364 -6.966626860121627 0.328955914537092 1.016441997388324 0.6524095817393255 0.9999428396351666 0.000713043481628958 0.07741333533199772 0.012937505453980917 0.0019526921420675676 0.011638532122941855 1.0798741368491687e-07 6.966626860121627 -0.3640324156489986 VLANNSLSFEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLANNSLSFEK 11 0 O76094;O76094-2;D6RDY6;R4GNC1 O76094 SRP72 Signal recognition particle subunit SRP72 0 5345800.0 1150100.0 1658700.0 2537000.0 False True 1575323.050283856 1585413.149412606 1937812.8511551141 1.0 1.0064050983872368 1.2301050573759722 20.587216280636166 -6.913024695182807 0.8748827011976923 0.9937186417128168 1.2609660881942661 0.9920138261798058 0.009561633122504696 0.10245179682539722 0.1281688892433038 0.007947240618650616 0.02242618112672933 1.2217301872395006e-07 6.913024695182807 0.2672474464814494 VLAQNSGFDLQETLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLAQNSGFDLQETLVK 16 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 16917600.0 0.0 9406300.0 7511300.0 False True 0.0 8990698.56352552 5737285.640079383 0.0 VLAQNSGFDLQETLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLAQNSGFDLQETLVK 16 0 P40227;P40227-2 P40227;P40227-2 CCT6A T-complex protein 1 subunit zeta 0 16679300.0 10225000.0 2858500.0 3595800.0 False True 8502540.544304153 2843100.6931321756 4347665.154899282 1.0 0.33438249171734524 0.5113371858969589 23.019462549754742 -10.760317744357915 10.538023405174002 1.001719903485618 0.42285983880856437 0.9341381453821231 0.07224145138838295 0.00292272699060139 6.647597570655706e-05 0.07003392862813138 0.023315828177754978 1.736529860580517e-11 10.760317744357915 -0.5788600646770535 VLASLIIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLASLIIR 8 0 A0A1W2PQ90;Q92878;Q92878-2;Q92878-3;A0A494BZX8;H7C0V2 A0A1W2PQ90 RAD50 DNA repair protein RAD50 0 2526870.0 626020.0 1087100.0 813750.0 False True 820718.2823863038 924908.917482611 729550.9560411851 1.0 1.1269505472613144 0.8889176367802574 19.64652756568261 -6.76181291621117 1.6054141769513135 1.0735754562638227 0.8879631533252362 0.6983535933731411 0.05341114547666971 0.2799136993209588 1.4222375278648989 0.026243291106716696 0.06296023398989335 1.7305616837034592e-07 6.76181291621117 -0.18561230293858644 VLASLIIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLASLIIR 8 0 A0A1W2PQ90;Q92878;Q92878-2;Q92878-3;A0A494BZX8;H7C0V2 A0A1W2PQ90 RAD50 DNA repair protein RAD50 0 16070800.0 4413900.0 5924500.0 5732400.0 False True 6696208.999313852 4867226.686670221 4599388.627399822 1.0 0.7268630186377034 0.6868645569263314 22.674913126717822 -13.999999999999998 0.27055294143860875 3.114443329245184 0.6736586067011427 0.9995845167952937 0.0028362879077020084 14.91016967085934 0.16466205770594414 17.34622958134274 0.016566387008593073 1.0000000000000041e-14 13.999999999999998 -2.4407847225440413 VLASLIIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLASLIIR 8 0 A0A1W2PQ90;Q92878;Q92878-2;Q92878-3;A0A494BZX8;H7C0V2 A0A1W2PQ90 RAD50 DNA repair protein RAD50 0 3903020.0 626020.0 1439800.0 1837200.0 False True 857476.5115543865 1376184.8752181048 1403291.198321707 1.0 1.6049242826761891 1.6365360210017854 19.709737627205502 -11.403734312479209 0.4879249590114016 2.3160030547552703e-14 1.6354397336796849 0.9998315685162638 0.0038012785421722406 3.8637922501162016 0.23988366385543727 4.128389902610831 0.006582048539875216 3.94698692309167e-12 11.403734312479209 1.6354397336796618 VLASLIIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLASLIIR 8 0 A0A1W2PQ90;Q92878;Q92878-2;Q92878-3;A0A494BZX8;H7C0V2 A0A1W2PQ90 RAD50 DNA repair protein RAD50 0 14140600.0 4413900.0 5716600.0 4010100.0 False True 5713880.560976599 5398466.184704739 3280302.947100674 1.0 0.9447985702700878 0.5740937200374406 22.44603944881027 -6.933500675444043 0.7174780696718759 1.0049712319822712 0.49073017482898157 0.9971825742436263 0.010037882083163755 0.09086062175497359 0.06907195134175402 0.0093434273397063 0.032920671812423134 1.1654652382257138e-07 6.933500675444043 -0.5142410571532896 VLATVTK(ub)PVGGDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLATVTKPVGGDK 13 1 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 23457500.0 5716300.0 10832000.0 6909200.0 True False 7494124.656727944 9215907.822805297 6194302.261726274 1.0 1.229751070998212 0.826554473732334 22.837328544875838 -6.752105107430258 1.641757511276271 1.1347484720562264 0.8256069630329942 0.6581358577528769 0.09655505314668714 0.29636882523832303 1.5722551763543664 0.04644396592874871 0.11251845245854045 1.7696806105039908e-07 6.752105107430258 -0.30914150902323223 VLATVTK(ub)PVGGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLATVTKPVGGDK 13 1 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 46189000.0 10797000.0 15661000.0 19731000.0 True False 10454255.144978995 21914518.97103607 14562859.182688018 1.0 2.096229589495073 1.3930078212872314 23.317586939249875 -10.125746182024479 4.847511539341872 0.9999569506561063 1.7446187053955204 0.5991877880365412 0.28708908470290284 0.00013357935446187645 2.409237333523294e-05 0.27798881709838136 0.09265760365887643 7.486068866136784e-11 10.125746182024479 0.7446617547394141 VLATVTK(ub)PVGGDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLATVTKPVGGDK 13 1 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 45411900.0 14132000.0 8331900.0 22948000.0 True False 21439277.18758999 6845007.347568174 18412317.741534274 1.0 0.31927416617992926 0.8588124301220446 24.353752931226538 -10.152422824309998 7.407292825348506 1.0000002165427915 0.589043298151179 0.4361579720702905 0.22026557389420906 7.875783525159476e-07 9.009747274086692e-08 0.21327133608547433 0.07109040828625758 7.040073214521044e-11 10.152422824309998 -0.4109569183916125 VLATVTK(ub)PVGGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLATVTKPVGGDK 13 1 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 19258600.0 5716300.0 5937000.0 7605300.0 True False 7829770.587199033 5674683.708966437 5809084.776070151 1.0 0.7247573406868435 0.7419227308610393 22.90053860639873 -10.074493962796563 4.935312378750117 1.0000072159981697 0.7333400357721235 0.9969018269142821 0.00700774120005016 5.564208164045942e-07 1.0434372480126756e-07 0.006785399805978609 0.0022617387459624785 8.423761013743064e-11 10.074493962796563 -0.2666671802260462 VLATVTK(ub)PVGGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLATVTKPVGGDK 13 1 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 39931500.0 10797000.0 24163000.0 4971500.0 True False 8978183.88820067 24032829.123020023 6011017.664381163 1.0 2.676802950606136 0.6695137612720292 23.09799221468415 -6.685075747320022 1.884158409758448 2.0560664722113517 0.6768761476551027 0.3474127094796341 0.7098940759652911 0.4273177784862191 2.9372380399855946 0.3018698721245499 0.7909331907134867 2.0650199546667988e-07 6.685075747320022 -1.379190324556249 VLATVTK(ub)PVGGDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLATVTKPVGGDK 13 1 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 33315500.0 14132000.0 13367000.0 5816500.0 True False 18294152.583366502 12623114.699462652 4757956.682329888 1.0 0.690008167469856 0.26008073676262766 24.124879253318987 -7.203229689439475 0.3793312346763011 1.035529432345563 4.48433428467607e-12 0.9997530981710154 0.004767207391064803 0.08921727753477947 0.023368889198006074 0.008906044060143638 0.04343071926799362 6.262825490785644e-08 7.203229689439475 -1.0355294323410786 down VLATVTKPVGGDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLATVTKPVGGDK 13 1 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 0 19749600.0 1386200.0 9595800.0 8767600.0 False True 1817321.6239798937 8164144.04413543 7860412.856757856 1.0 4.492404611494215 4.325273387516145 20.793382335213916 -10.14451921873572 4.182459857859881 0.9991014495878117 4.408838999827657 0.9982003782905775 0.06823103797748681 12020290.139150036 29527687.55280964 156171.34639360438 0.02497000588590355 7.169366484426733e-11 10.14451921873572 3.4097375502398455 VLATVTKPVGGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLATVTKPVGGDK 13 1 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 0 22751500.0 5869300.0 2254200.0 14628000.0 False True 5682982.284192387 3154313.815497702 10796487.969406538 1.0 0.5550455126829529 1.8997926492640536 22.438216787344487 -6.8175415193689854 1.3825957014929606 0.7595626476448281 1.9276034788990233 0.8786098460929934 0.19488724730582635 0.19669546401263535 0.7394877965095962 0.11078973637556454 0.25552047353928115 1.5221536051777194e-07 6.8175415193689854 1.1680408312541952 VLATVTKPVGGDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLATVTKPVGGDK 13 1 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 0 82857100.0 1613900.0 78452000.0 2791200.0 False True 2448404.2918943847 64451627.65172629 2239518.0965735777 1.0 26.32393182167584 0.9146847618212648 21.223410371534612 -3.653982668488697 12.275584046102804 9.999999999999998 12.930420083851079 0.0 11.972380758726922 0.0 0.0 3.660993726631043 0.0 0.00022182849437512385 3.653982668488697 2.9304200838510805 VLATVTKPVGGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLATVTKPVGGDK 13 1 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 0 25095000.0 1386200.0 14302000.0 9406800.0 False True 1898715.600646448 13670090.349610575 7185107.579127284 1.0 7.199651356399228 3.7841936816029738 20.856592396736808 -9.185357264637533 10.168058119463634 0.9999349216553375 5.491922519001545 0.6975420716062215 1.394354757395106 0.0 0.0 1.350078188294611 0.45002606276487017 6.525934873392596e-10 9.185357264637533 4.491987597346207 VLATVTKPVGGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLATVTKPVGGDK 13 1 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 0 7486360.0 5869300.0 1131100.0 485960.0 False True 4880583.004076704 1125006.5397942294 587571.9891748292 1.0 0.23050658883467862 0.12038971341826088 22.218622062778763 -13.999999999999998 0.2738483770939362 7.063879223404548 0.08517981670283638 0.9995916601128094 0.00790692923103383 15.075295443302991 0.16569434649243675 51.01020393974954 0.04487108857931372 1.0000000000000041e-14 13.999999999999998 -6.978699406701712 VLATVTKPVGGDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLATVTKPVGGDK 13 1 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 0 7272600.0 1613900.0 2103300.0 3555400.0 False True 2089225.3647251031 1986249.5060507038 2908353.6814846895 1.0 0.9507109857973849 1.3920727416916872 20.99453669362706 -6.879169627879985 1.084378931904727 0.9697716016648484 1.4228630149603394 0.9730112339739725 0.03244092828490432 0.12837009501251204 0.27672971660801055 0.0230617224710525 0.05565528613959883 1.320779659837528e-07 6.879169627879985 0.45309141329549096 VLATVTKPVGGDK(ub)NGGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLATVTKPVGGDKNGGTR 18 2 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 57513400.0 3750600.0 36828400.0 16934400.0 True False 4917072.920862067 31333746.275978845 15182190.73423515 1.0 6.372438802572279 3.0876480740849765 22.22936832000558 -9.474678455703174 9.523915706781109 1.0002107048827171 4.730043438315051 0.6322579988627737 1.341010204954301 0.0 0.0 1.2984275452273377 0.43280918174244576 3.352135337407938e-10 9.474678455703174 3.729832733432334 VLATVTKPVGGDK(ub)NGGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLATVTKPVGGDKNGGTR 18 2 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 91957400.0 5488600.0 43906600.0 42562200.0 True False 5314367.397307744 61438734.34989414 31413882.98136961 1.0 11.560874466642817 5.911123682808205 22.341466538204877 -9.656001045175481 8.367000718434936 0.9998037625779891 8.735999074772794 0.7142730088148248 2.3065011018300443 0.0 0.0 2.23326008759185 0.7444200291972832 2.207999419228999e-10 9.656001045175481 7.736195312194805 VLATVTKPVGGDK(ub)NGGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLATVTKPVGGDKNGGTR 18 2 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 124594400.0 47707600.0 26434000.0 50452800.0 True False 72375917.09274462 21716646.17021532 40480781.96575221 1.0 0.3000534852275098 0.5593128707976017 26.10900638816691 -10.307049541142046 5.6969184342004935 1.0000643330199313 0.4296831780129116 0.8658099141517783 0.10584220094571829 8.649333126393324e-05 1.052086049615203e-05 0.10249275550200697 0.03416042346572306 4.931175494985437e-11 10.307049541142046 -0.5703811550070197 VLATVTKPVGGDK(ub)NGGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLATVTKPVGGDKNGGTR 18 2 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 43841700.0 3750600.0 25302700.0 14788400.0 True False 5137298.176153928 24184743.04916039 11295684.49665835 1.0 4.707677502820453 2.1987597584057186 22.29257838152847 -6.542940105596717 2.416016474342239 3.5781944058818773 2.2004312704298754 0.0 1.6256364090860298 0.817631955901164 8.925369398992835 0.579316525679862 1.8424291728411835 2.8645730015438063e-07 6.542940105596717 -1.377763135452002 VLATVTKPVGGDK(ub)NGGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLATVTKPVGGDKNGGTR 18 2 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 95094500.0 5488600.0 74424000.0 15181900.0 True False 4564014.086207113 74023063.13999268 18356365.09682556 1.0 16.218850718208223 4.0219781863294966 22.121871813639153 -9.390872513525265 9.974711594362052 0.9999988883165553 10.120414452301281 0.4271113614560267 4.97935236014523 0.0 0.0 4.821237191435227 1.607079063811742 4.065626574905219e-10 9.390872513525265 9.120415563984725 VLATVTKPVGGDK(ub)NGGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLATVTKPVGGDKNGGTR 18 2 Q02878;F8VZ45;U3KQR5;F8VZA3;F8VWR1;F8VU16 Q02878 RPL6 60S ribosomal protein L6 1 118677900.0 47707600.0 54402600.0 16567700.0 True False 61758428.65738851 51375047.486271136 13552548.598957611 1.0 0.8318710272128151 0.21944451783483393 25.88013271025936 -6.947027235771535 0.5905823520677004 1.0070665608898373 0.01340184513532039 0.9989468400441008 0.010885412954720739 0.084701940994317 0.04107572055395169 0.0112785419366688 0.05131502569958495 1.1297250643630336e-07 6.947027235771535 -0.9936647157545169 down VLCELADLQDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLCELADLQDK 11 0 P17987;E7ERF2;F5H136;F5H676;F5H726;F5GZI8 P17987 TCP1 T-complex protein 1 subunit alpha 0 18316700.0 1081100.0 6057600.0 11178000.0 False True 1417332.5693872909 5153829.692339858 10021407.786947304 1.0 3.6362881963319627 7.070611374773906 20.434746887855763 -6.967494493850076 0.31228855226729096 0.48501120131940817 10.331418636759892 0.9999557203403312 0.01653888385786054 0.07712434859382104 0.011925887532804474 0.05378528117770155 0.3042338658562437 1.0777189173363094e-07 6.967494493850076 9.846407435440485 VLCELADLQDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLCELADLQDK 11 0 P17987;E7ERF2;F5H136;F5H676;F5H726;F5GZI8 P17987 TCP1 T-complex protein 1 subunit alpha 0 11109300.0 1081100.0 5240300.0 4787900.0 False True 1480811.8856289673 5008766.218645245 3657096.629895767 1.0 3.38244598605298 2.4696564535896024 20.497956949378654 -10.345689771468326 6.039280865604179 0.9997846700759776 2.926051219821292 0.8558358215238155 0.37264476618148806 0.0010805152533246004 0.00011706634825673707 0.3608488092934123 0.12027058112268757 4.511388503977922e-11 10.345689771468326 1.9262665497453144 VLCLAVAVGHVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLCLAVAVGHVK 12 0 P62906 P62906 RPL10A 60S ribosomal protein L10a 0 42726000.0 14580000.0 21474000.0 6672000.0 False True 19114521.192920852 18270162.904996388 5981645.44234322 1.0 0.9558263437832187 0.31293723666792916 24.18816572620726 -6.920799369130529 0.8187873371909878 1.0137806749048084 0.20733908660548872 0.9943998069229055 0.023497336915431086 0.09770391579916335 0.10319762044505337 0.020331437132391904 0.06137454210644069 1.2000535634375735e-07 6.920799369130529 -0.8064415882993197 down VLCLAVAVGHVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLCLAVAVGHVK 12 0 P62906 P62906 RPL10A 60S ribosomal protein L10a 0 387990000.0 116140000.0 145990000.0 125860000.0 False True 176192870.97132042 119936943.87492363 100983715.8336024 1.0 0.6807139427022914 0.5731430294364175 27.392580310925936 -13.999999999999998 0.15193880549139963 2.5486729499044865 0.457391712826709 0.9995598969276066 0.003802745262444875 11.965569345130465 0.12285765902013907 5.4680477927494815 0.10453313005565512 1.0000000000000041e-14 13.999999999999998 -2.0912812370777774 VLCLAVAVGHVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLCLAVAVGHVK 12 0 P62906 P62906 RPL10A 60S ribosomal protein L10a 0 103353000.0 14580000.0 36062000.0 52711000.0 False True 19970620.009684928 34468661.598913185 40261747.417121485 1.0 1.7259685268758458 2.0160489457811623 24.25137578773015 -10.486702767877576 0.1971358490717852 1.3257637267693651e-21 2.2659942600949043 0.9994052203924153 0.010421874767601303 2.215778145719547 0.10056087821496634 1.2685886754760016 0.18177057931524412 3.2605978070411064e-11 10.486702767877576 2.2659942600949043 VLCLAVAVGHVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLCLAVAVGHVK 12 0 P62906 P62906 RPL10A 60S ribosomal protein L10a 0 297965000.0 116140000.0 96783000.0 85042000.0 False True 150345519.46166036 91396940.97090551 69565228.60460728 1.0 0.6079126354956834 0.46270237286550553 27.163706633018386 -13.999999999999998 0.13798939365046192 2.869876087968106 0.278568425717134 0.9996110699591945 0.004475508641504828 11.93247314870113 0.11623339826924384 6.0150409306249415 0.16440089281625073 1.0000000000000041e-14 13.999999999999998 -2.591307662250972 VLCNVACPPPPVEGQQK(ub)DLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLCNVACPPPPVEGQQKDLK 20 1 Q69YN4-2;Q69YN4-3;Q69YN4;Q69YN4-4;H0YBN5 Q69YN4-2 KIAA1429 Protein virilizer homolog 1 9266000.0 2492400.0 2853800.0 3919800.0 True False 3267560.5364359333 2428024.1640252713 3514216.6973766396 1.0 0.7430693745229339 1.0754863324459611 21.6397825336714 -6.700312094858999 1.8295901732873567 0.8405051551681825 1.0745081146328148 0.41909686908753063 0.10844755532771655 0.39489427990063164 2.5700829233538083 0.047282042731865974 0.12155762700864084 1.9938289847229158e-07 6.700312094858999 0.23400295946463234 VLCNVACPPPPVEGQQK(ub)DLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLCNVACPPPPVEGQQKDLK 20 1 Q69YN4-2;Q69YN4-3;Q69YN4;Q69YN4-4;H0YBN5 Q69YN4-2 KIAA1429 Protein virilizer homolog 1 20220300.0 4379100.0 8559000.0 7282200.0 True False 6643414.855093064 7031579.578227773 5842869.978098353 1.0 1.0584284937191797 0.8794979849284911 22.663493577177167 -6.818753887445903 1.3771263663232292 1.0315348310824153 0.8756916999391204 0.8814949270201972 0.025645916257869026 0.19512555352712738 0.7274451809973023 0.014634834878148406 0.0337448109632851 1.5179103161077224e-07 6.818753887445903 -0.15584313114329484 VLCNVACPPPPVEGQQK(ub)DLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLCNVACPPPPVEGQQKDLK 20 1 Q69YN4-2;Q69YN4-3;Q69YN4;Q69YN4-4;H0YBN5 Q69YN4-2 KIAA1429 Protein virilizer homolog 1 8972200.0 2492400.0 2677100.0 3802700.0 True False 3413907.6345774136 2558816.8700141604 2904580.57906486 1.0 0.7495272701866466 0.8508081910729257 21.702992595194292 -10.09367252030789 6.162157435530202 1.0000005196739477 0.8001677306793519 0.8384638721236023 0.04134776280843947 2.951908102714105e-07 4.341998656032683e-08 0.04003490328860023 0.013344933063333533 8.05985965720836e-11 10.09367252030789 -0.19983278899459578 VLCNVACPPPPVEGQQK(ub)DLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLCNVACPPPPVEGQQKDLK 20 1 Q69YN4-2;Q69YN4-3;Q69YN4;Q69YN4-4;H0YBN5 Q69YN4-2 KIAA1429 Protein virilizer homolog 1 16466600.0 4379100.0 6062600.0 6024900.0 True False 5668831.274966042 5725210.980546284 4928430.020694461 1.0 1.0099455607065284 0.8693908464799005 22.434619899269617 -6.889914743014112 1.0229064468936506 1.0075676355718426 0.8573228859569806 0.9808429573032502 0.008864092564930391 0.11921157283265432 0.2222615706529879 0.006603573750197927 0.01645747174292662 1.2885024746746575e-07 6.889914743014112 -0.150244749614862 VLCQGLK(ub)DSPCQLEALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLCQGLKDSPCQLEALK 17 1 P13489 P13489 RNH1 Ribonuclease inhibitor 1 24606500.0 2287200.0 4330300.0 17989000.0 True False 2960825.4874522933 4089314.9983603745 14715186.582727127 1.0 1.3811401636775 4.969960791370088 21.49756802917207 -6.927196865315465 0.7694533633094907 0.9393766724303525 5.656753519404549 0.9959580324981276 0.1137003932542435 0.09411981798796097 0.08500401235314568 0.10190867700365637 0.32987347240589043 1.1825054055319135e-07 6.927196865315465 4.717376846974196 up VLDALFPCVQGGTTAIPGAFGCGK(ub)TVISQSLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLDALFPCVQGGTTAIPGAFGCGKTVISQSLSK 33 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 181023000.0 11036000.0 17797000.0 152190000.0 True False 16742418.839671856 14620986.301404325 122109579.79275334 1.0 0.8732899613501063 7.293425219025678 23.997004638689155 -6.90239830274392 0.9459735330554454 0.750353353591964 8.00115479069774 0.9877223814740226 0.33208763667408175 0.10966170932538893 0.16762750050491435 0.26205467415794076 0.6904095736570767 1.25199241349751e-07 6.90239830274392 7.250801437105776 up VLDALFPCVQGGTTAIPGAFGCGK(ub)TVISQSLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLDALFPCVQGGTTAIPGAFGCGKTVISQSLSK 33 1 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 67996000.0 11036000.0 10367000.0 46593000.0 True False 14286319.552082669 9790067.336674586 38113552.08455198 1.0 0.6852756793646957 2.66783561333652 23.768130960781605 -6.866271735103146 1.153546092652914 0.8254260533642908 2.776048282393769 0.9608233335144523 0.1721894592854192 0.14048466226263434 0.3517163946503806 0.1160825417067347 0.27320417175293304 1.3605931022307854e-07 6.866271735103146 1.9506222290294783 up VLDALVFHFLGFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLDALVFHFLGFR 13 0 Q13895 Q13895 BYSL Bystin 0 373070000.0 115810000.0 133990000.0 123270000.0 False True 175692236.8450888 110078437.63135165 98905630.46883957 1.0 0.6265412724434143 0.5629482112863448 27.388475204784815 -13.999999999999998 0.2490663458931459 3.5850603188758083 0.5371503902327653 0.9995409425809625 0.004130752829980081 13.96122632549185 0.15792368733425546 18.046476784993985 0.02950105668872576 1.0000000000000041e-14 13.999999999999998 -3.047909928643043 VLDALVFHFLGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLDALVFHFLGFR 13 0 Q13895 Q13895 BYSL Bystin 0 408200000.0 115810000.0 173850000.0 118540000.0 False True 149918327.95638782 164175094.67356792 96966936.32311267 1.0 1.0950968898300912 0.6467984111410378 27.159601526877264 -6.8512822413325525 1.2290412408023204 1.050804525892169 0.6284446502682782 0.942128151440026 0.04639629382802849 0.15605529797443218 0.4529995244001216 0.0295307392586951 0.06838775665691019 1.4083732207572674e-07 6.8512822413325525 -0.42235987562389077 VLDAMLPYLINYYGNPHSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLDAMLPYLINYYGNPHSR 19 0 F2Z2E7;Q9Y697-2;Q9Y697;F8WER8;A2A2M1;F8WB23;Q8WV90;Q9Y697-3 F2Z2E7 NFS1 Cysteine desulfurase, mitochondrial 0 20568000.0 7174400.0 4781500.0 8612100.0 False True 6946652.59906801 6690777.8851930965 6356332.652538014 1.0 0.9631657535444852 0.9150209488510774 22.727886519522055 -6.967448438262217 0.3132825264099601 1.0071354058974291 0.869513812119291 0.9999549985569492 0.00023334316052829232 0.07714047409233117 0.011984454127250776 0.0007507157034588527 0.004260933290161974 1.077833212157598e-07 6.967448438262217 -0.1376215937781381 VLDAMLPYLINYYGNPHSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLDAMLPYLINYYGNPHSR 19 0 F2Z2E7;Q9Y697-2;Q9Y697;F8WER8;A2A2M1;F8WB23;Q8WV90;Q9Y697-3 F2Z2E7 NFS1 Cysteine desulfurase, mitochondrial 0 22599000.0 5378600.0 7074400.0 10146000.0 False True 8159729.428330841 5811918.047460521 8140638.652850216 1.0 0.7122684763641005 0.9976603666030468 22.960089883423255 -10.890185813447639 9.775718465118306 1.0122450899674806 0.8549644214835755 0.2561480652102991 0.11651075130230026 0.0313487898110903 0.00035215174094540034 0.11373490185414929 0.03760368328732692 1.287698490374975e-11 10.890185813447639 -0.1572806684839051 VLDAMLPYLINYYGNPHSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLDAMLPYLINYYGNPHSR 19 0 F2Z2E7;Q9Y697-2;Q9Y697;F8WER8;A2A2M1;F8WB23;Q8WV90;Q9Y697-3 F2Z2E7 NFS1 Cysteine desulfurase, mitochondrial 0 15541400.0 7174400.0 4721100.0 3645900.0 False True 5965831.479809845 4695666.497235016 4408240.83326305 1.0 0.7870933855786161 0.7389147427616508 22.50829179495633 -13.999999999999998 0.2087875328950143 2.2252200379732026 0.7102017585469644 0.9994893645504629 0.0025634051645700364 12.718570809081706 0.14483676790678218 6.388784835066953 0.02878298975479504 1.0000000000000041e-14 13.999999999999998 -1.5150182794262381 VLDAMLPYLINYYGNPHSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLDAMLPYLINYYGNPHSR 19 0 F2Z2E7;Q9Y697-2;Q9Y697;F8WER8;A2A2M1;F8WB23;Q8WV90;Q9Y697-3 F2Z2E7 NFS1 Cysteine desulfurase, mitochondrial 0 15698100.0 5378600.0 6572100.0 3747400.0 False True 6962703.728056537 6206356.8576597925 3065411.651571054 1.0 0.89137167112985 0.44026168156758355 22.731216205515704 -6.944014385608564 0.6210970061459047 1.0049337203342268 0.3027557018688604 0.9986438153778873 0.008924926524116234 0.08598208461274034 0.04662211902112104 0.008979105467558729 0.03819341192791491 1.1375896035813926e-07 6.944014385608564 -0.7021780184653663 down VLDDGELLVQQTK(ub)NSDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLDDGELLVQQTKNSDR 17 1 I3L0N3;P46459;P46459-2 I3L0N3 NSF Vesicle-fusing ATPase 1 6414300.0 2101900.0 1736000.0 2576400.0 True False 2035176.33502189 2429193.853120406 1901563.5496567541 1.0 1.1936036260436755 0.9343483004072476 20.95672236953576 -6.706758218531304 1.8064287725209436 1.1194105010874449 0.9350041037907227 0.44989635257916094 0.08162550424528568 0.3816024262615049 2.4252311961456945 0.03598406672279289 0.09178897287169681 1.9644536278106435e-07 6.706758218531304 -0.18440639729672215 VLDFEHFLPMLQTVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLDFEHFLPMLQTVAK 16 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180 P60660-2 MYL6 Myosin light polypeptide 6 0 11240000.0 3958300.0 4711700.0 2570000.0 False True 5189369.6322317235 4008732.7260627495 2304081.0531807626 1.0 0.7724893407407495 0.4440001804592742 22.307127870202812 -6.965883611117487 0.3425486999749072 1.034593684968581 0.17093692034118427 0.9999302175917651 0.0019065336348741242 0.07766236977736328 0.013809748480189446 0.004601850161470792 0.02837977495226584 1.0817238093590534e-07 6.965883611117487 -0.8636567646273968 down VLDFEHFLPMLQTVAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VLDFEHFLPMLQTVAK 16 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180 P60660-2 MYL6 Myosin light polypeptide 6 0 756627800.0 314552000.0 213226000.0 228849800.0 False True 304566718.93705976 298368253.7589004 168907172.03316197 1.0 0.9796482517860388 0.5545818421088468 28.182183061240206 -6.916877992070678 0.847553984699369 1.0104750745156388 0.49072661209219676 0.9932689135521359 0.01684702337044968 0.10004388853715988 0.11538863919511513 0.014280375192143134 0.041579434909427906 1.2109382790667716e-07 6.916877992070678 -0.5197484624234421 VLDFEHFLPMLQTVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VLDFEHFLPMLQTVAK 16 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180 P60660-2 MYL6 Myosin light polypeptide 6 0 232255500.0 71558300.0 9341200.0 151356000.0 False True 98015337.3003455 8928474.896782434 115608830.07466827 1.0 0.09109263042602377 1.179497344588139 26.54650418196851 -6.685114047493136 1.883587241807228 0.4275842266222773 1.1755485550346443 0.3477120710319258 0.3847937414325685 0.42727271158698754 2.9350638903403565 0.1636572091242384 0.42884809021257453 2.0648378498101452e-07 6.685114047493136 0.7479643284123669 VLDFEHFLPMLQTVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VLDFEHFLPMLQTVAK 16 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180 P60660-2 MYL6 Myosin light polypeptide 6 0 574766800.0 314552000.0 105554800.0 154660000.0 False True 261563925.01632845 104986155.34141256 186998690.9329557 1.0 0.4013785744148726 0.7149253893528402 27.962588336674482 -10.577707096599852 6.5699870069849995 1.0007427010242569 0.5581519818838905 0.7258596863522169 0.1280049511788145 0.001394702521788233 8.964571991779935e-05 0.12413287731309691 0.041313420345636835 2.6441914913813207e-11 10.577707096599852 -0.4425907191403664 VLDFEHFLPMLQTVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLDFEHFLPMLQTVAK 16 0 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180 P60660-2 MYL6 Myosin light polypeptide 6 0 165298000.0 46056000.0 75340000.0 43902000.0 False True 59620399.89948534 71147262.77081732 35912286.47256023 1.0 1.1933375638332726 0.6023489700355101 25.82930271634487 -6.818596604318579 1.3780486182111975 1.1043561131648763 0.5898423490647385 0.8811044102334907 0.08483391574402287 0.1953088340162528 0.7291835249690579 0.04838228312943018 0.11155112293223295 1.518460138699911e-07 6.818596604318579 -0.5145137641001377 VLDFEHFLPMLQTVAKNK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLDFEHFLPMLQTVAKNK 18 1 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3;G3V1Y7;F8VZU9;F8W180 P60660-2 MYL6 Myosin light polypeptide 6 1 7453400.0 1330700.0 2248300.0 3874400.0 True False 1106536.0100054294 2236187.9616473904 4684519.126798424 1.0 2.0208903654535546 4.2334990316089565 20.07761897085706 -6.958443332592967 0.4568432919074101 0.9334328247223529 5.409680580490443 0.9997080382141003 0.023060879213469308 0.0802619392030133 0.023221822145613236 0.029891899676612273 0.18285029523848065 1.1004154198125931e-07 6.958443332592967 4.476247755768091 VLDGK(ub)TIETSPSLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLDGKTIETSPSLSR 15 1 Q9NVI1;Q9NVI1-1;Q9NVI1-2;F8W7R3;H3BP78 Q9NVI1 FANCI Fanconi anemia group I protein 1 22300800.0 3395600.0 9345000.0 9560200.0 True False 2823591.8505857373 9294656.630162729 11559193.618629538 1.0 3.29178476281358 4.093790544207603 21.429100131838428 -9.408980430981513 0.3257235028805265 5.083024864138355e-22 4.348930167818276 0.9985140326427541 0.05053436926306145 0.7863998672145988 0.12880763869117198 1.1486944374499042 0.2542540756353939 3.899595575971642e-10 9.408980430981513 4.348930167818276 VLDIIATINK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLDIIATINK 10 0 P07686;Q5URX0;H0YA83 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 5446400.0 2549900.0 989600.0 1906900.0 False True 2468954.8202446937 1384752.4406958246 1407425.6842262326 1.0 0.5608658487151191 0.570049185463323 21.23546900596473 -10.427457737101903 5.977331751359482 1.0001643452644315 0.565457517089221 0.9996651476267552 0.0037490815282087238 8.213972283848028e-06 7.867772520395269e-07 0.0036313867569030506 0.001210010860193776 3.737164914290554e-11 10.427457737101903 -0.43470682817521056 VLDIIATINK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLDIIATINK 10 0 P07686;Q5URX0;H0YA83 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 24553800.0 5173900.0 11351000.0 8028900.0 False True 7849184.562756271 9325325.36423221 6441984.395808124 1.0 1.1880629496827104 0.8207202091252644 22.904111352197994 -6.767553866428447 1.5838011235581109 1.1082086753340132 0.8188433156471325 0.7210663773067651 0.07921139203880631 0.27043360606278033 1.3383887033587807 0.039430280218928436 0.09407325277763733 1.707835880562562e-07 6.767553866428447 -0.2893653596868807 VLDIIATINK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLDIIATINK 10 0 P07686;Q5URX0;H0YA83 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 5611800.0 2549900.0 1191200.0 1870700.0 False True 2120354.82972334 1184782.769165312 2261854.7208604696 1.0 0.5587662746616331 1.0667340622208936 21.015874281399007 -6.67706326390873 1.9124298815526133 0.7200886607435085 1.0647526599617638 0.31065224255345125 0.18712753520629102 0.4451017605505927 3.144825159409113 0.07859022456200884 0.20805130389359758 2.1034720035593958e-07 6.67706326390873 0.3446639992182553 VLDIIATINK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLDIIATINK 10 0 P07686;Q5URX0;H0YA83 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 20291300.0 5173900.0 8486200.0 6631200.0 False True 6697715.542816284 8013935.510030662 5424389.6418578075 1.0 1.1965177468048946 0.8098865362647123 22.675237674290443 -6.768553119056525 1.5802545182765215 1.1129265043474377 0.807843155887836 0.7249049118281106 0.08279089175443904 0.2687733561132965 1.324423693429102 0.04130347928674682 0.09844001206121925 1.7039108992720659e-07 6.768553119056525 -0.3050833484596017 VLDLDLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLDLDLFR 8 0 Q5T5C7;P49591 Q5T5C7 SARS Serine--tRNA ligase, cytoplasmic 0 2775040.0 762610.0 904930.0 1107500.0 False True 999789.0951257445 769917.9713895125 992906.5238901551 1.0 0.770080385096298 0.9931159768903823 19.931264265817312 -10.705523341443383 8.723471022002206 1.000319521272306 0.8815981810081158 0.2731274757703547 0.09105389906253095 0.0005673386821557576 1.9151426970810118e-05 0.08839686660408855 0.02938751955636944 1.9700473228785946e-11 10.705523341443383 -0.11872134026419012 VLDLDLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLDLDLFR 8 0 Q5T5C7;P49591 Q5T5C7 SARS Serine--tRNA ligase, cytoplasmic 0 4042810.0 762610.0 1614200.0 1666000.0 False True 1044567.5257603433 1542879.3065544255 1272525.1123470317 1.0 1.477050806678448 1.2182315465156333 19.994474327340203 -10.142746149758672 4.390135945298949 0.9999462298437423 1.3476411766077296 0.7063586106193549 0.10566252061610332 73861531.24172969 5.12062238843587 44748.169081252396 0.03617109124737175 7.198696273328238e-11 10.142746149758672 0.3476949467639874 VLDLQQIK(ub)GMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLDLQQIKGMK 11 1 Q9UNM6;J3KNQ3;Q9UNM6-2 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 6564500.0 2023300.0 3353800.0 1187400.0 True False 2652565.893665074 2853426.11301001 1064539.238345074 1.0 1.0757229895116407 0.4013243331249316 21.338957159590716 -6.879006806460371 1.0852879319545945 1.046346624186309 0.3544244391287607 0.9728769889432547 0.0496797106168262 0.12851517502438056 0.2776135469995273 0.03529203452933226 0.08513647114821306 1.3212749264035533e-07 6.879006806460371 -0.6919221850575483 down VLDLQQIK(ub)GMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLDLQQIKGMK 11 1 Q9UNM6;J3KNQ3;Q9UNM6-2 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 7127100.0 2087500.0 1948000.0 3091600.0 True False 2021233.455139727 2725846.558685802 2281817.2139880527 1.0 1.3486055021275933 1.128923137594866 20.946804533852767 -10.184049200098633 4.162936945594439 0.9999111411573283 1.2387643197597271 0.6116541175685772 0.08968494993305526 62947987.106715195 10.352551396968511 57783.36120509595 0.030701543816195206 6.545620162288641e-11 10.184049200098633 0.23885317860239885 VLDLQQIK(ub)GMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLDLQQIKGMK 11 1 Q9UNM6;J3KNQ3;Q9UNM6-2 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 7033300.0 2087500.0 3165000.0 1780800.0 True False 1735848.7419300624 3147949.516796687 2153157.0465111053 1.0 1.8134929851644404 1.240405914697985 20.727209809287043 -10.068653954991849 5.370944905534559 0.9999947572971397 1.526949449931688 0.5299182161200087 0.23396181680654132 1.4687951131740117e-05 2.5467019360804096e-06 0.22653480897659356 0.07551085167810603 8.53780133431264e-11 10.068653954991849 0.5269546926345483 VLDLQQIK(ub)GMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLDLQQIKGMK 11 1 Q9UNM6;J3KNQ3;Q9UNM6-2 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 1 15034300.0 3243900.0 5019700.0 6770700.0 True False 4199292.496828658 4740349.282329069 5538502.07324869 1.0 1.1288447484687059 1.3189131448765274 22.001714850240006 -6.965533106530841 0.34878194369238663 0.9813728416645633 1.472786664552281 0.9999237147064666 0.001144097561830419 0.07778052090468478 0.014224687079822676 0.0026171766879392578 0.016350186192515784 1.0825971849439523e-07 6.965533106530841 0.4914138228877176 VLDPFTIK(ub)PLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLDPFTIKPLDR 12 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 6361000.0 1462600.0 2946100.0 1952300.0 True False 1917482.763838548 2506553.3638078533 1750294.723783972 1.0 1.3072103755394722 0.912808582581526 20.870782178793498 -6.698861411686865 1.8352169395050313 1.1909796469061575 0.9140171348206761 0.4120780172094719 0.1297045819866747 0.39787748787860366 2.6045379803937 0.05640420357557553 0.14524547763059584 2.0005001501574216e-07 6.698861411686865 -0.2769625120854814 VLDPFTIK(ub)PLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLDPFTIKPLDR 12 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 10086400.0 3039900.0 3236100.0 3810400.0 True False 2943400.0384571315 4528291.606038557 2812341.930450276 1.0 1.5384560531609535 0.9554739055872428 21.489052202080664 -6.663961865563068 1.9586577329531618 1.3454567827053203 0.9578749192616374 0.25265839872987017 0.22904626429143113 0.47511780750277377 3.507876952220183 0.09433916022884993 0.25406304056708845 2.1678944544748313e-07 6.663961865563068 -0.38758186344368295 VLDPFTIK(ub)PLDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLDPFTIKPLDR 12 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 22786100.0 3401600.0 4348500.0 15036000.0 True False 5160475.890270741 3572476.200014427 12064128.009487081 1.0 0.6922765023957896 2.3377936969402535 22.299072683979627 -6.858374291396207 1.1940069166185279 0.8337193860495385 2.4150038874278668 0.9516215490516505 0.1571125895463906 0.14848937208618612 0.4032008408486766 0.10269756177017395 0.23929188946789573 1.3855611851624675e-07 6.858374291396207 1.5812845013783283 up VLDPFTIK(ub)PLDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLDPFTIKPLDR 12 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 5225800.0 1462600.0 2204900.0 1558300.0 True False 2003362.7452788178 2107480.2273707413 1190261.6341959047 1.0 1.0519713578268788 0.5941318600442728 20.93399224031639 -6.8786743505133545 1.0871163316822203 1.0316830830829773 0.5624924196141454 0.9726024917377103 0.03387911076401795 0.12881318509038708 0.2794094444934978 0.024033587945515744 0.05793099044934029 1.3222867603063025e-07 6.8786743505133545 -0.46919066346883187 VLDPFTIK(ub)PLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLDPFTIKPLDR 12 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 9088100.0 3039900.0 4389300.0 1658900.0 True False 2527811.5404039286 4365653.969692167 2005768.3201130242 1.0 1.7270488325227609 0.7934801657692072 21.26945747751494 -6.69887287336901 1.8345277057580482 1.4519783216301434 0.7962904646735269 0.41222832669272336 0.30696317196735323 0.3979619534213879 2.6029877252031492 0.1335168403751694 0.3438947436521627 2.0004473546574944e-07 6.69887287336901 -0.6556878569566165 VLDPFTIK(ub)PLDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLDPFTIKPLDR 12 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 1 18352200.0 3401600.0 5790100.0 9160500.0 True False 4403438.255560393 5467875.845093044 7493382.994667395 1.0 1.2417287418958456 1.7017118351109404 22.070199006072077 -6.961006503722928 0.42100837157053717 0.9798872800077693 1.9809337579187654 0.999805726303852 0.004056780555049998 0.0793435139469384 0.019817170823811885 0.00595418940870027 0.03827948157158157 1.0939399839874355e-07 6.961006503722928 1.0010464779109962 VLDPFTIKPLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLDPFTIKPLDR 12 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 46602100.0 3883100.0 22517000.0 20202000.0 False True 5090781.703993891 19157551.370578542 18111690.831267625 1.0 3.7631846118148795 3.557742579505695 22.27945577255748 -10.265548566211823 4.345868650865959 0.9982958984709142 3.6604635956628497 0.9955476705512015 0.08387135871639452 29669322.682877526 1469.0213419237566 507835.90622487286 0.028711396899979254 5.4256457411450686e-11 10.265548566211823 2.6621676971919355 VLDPFTIKPLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLDPFTIKPLDR 12 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 41463600.0 15567000.0 6208600.0 19688000.0 False True 15072834.105944972 8687726.357421273 14531122.172660371 1.0 0.5763830674680279 0.9640603797881023 23.845447372863894 -10.416703337204122 8.646471395947028 1.00000207898357 0.7702217236280652 0.3189861581743334 0.15826860000629547 6.342880777829465e-06 4.2784304208724404e-07 0.15324429884249097 0.051080971004328776 3.830863369164289e-11 10.416703337204122 -0.22978035535550478 VLDPFTIKPLDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLDPFTIKPLDR 12 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 32881100.0 3883100.0 15565000.0 13433000.0 False True 5318787.006831791 14877286.833428085 10260402.06131913 1.0 2.797120248342102 1.929086847835796 22.34266583408037 -10.039376994318953 5.969361436046045 0.9999974868525408 2.363103548089054 0.766787648295877 0.3543731518226061 1.1852094695159909e-05 1.9083387910483823e-06 0.3431209624175846 0.11437344294594423 9.133200792662275e-11 10.039376994318953 1.3631060612365131 VLDPFTIKPLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLDPFTIKPLDR 12 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 19651200.0 15567000.0 2111700.0 1972500.0 False True 12944650.235030074 2100323.85296037 2384940.6301904498 1.0 0.16225419882544168 0.18424141146250977 23.62585264829817 -10.111583098820693 5.677000880173554 1.000007478794102 0.1732478051438775 0.9994698231396127 0.008976241971495911 8.496721156518999e-07 1.3296764809621116e-07 0.008691287378965845 0.002897069638877066 7.73422676292302e-11 10.111583098820693 -0.8267596736502245 VLDPFTIKPLDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLDPFTIKPLDR 12 1 P29401;P29401-2;A0A0B4J1R6 P29401 TKT Transketolase 0 7143300.0 1840600.0 2351200.0 2951500.0 False True 2382692.9836501796 2220353.65312909 2414357.284947417 1.0 0.93186728981239 1.0132892913667497 21.18416163772162 -6.684661444958619 1.8849427215372252 0.9570752343259931 1.0129948391394008 0.345807745949672 0.028846976900545815 0.4282190246246293 2.9453587416324156 0.012261167512651334 0.032150678483973565 2.0669908543408957e-07 6.684661444958619 0.05591960481340774 VLDPTCTIK(ub)TPEITVSIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLDPTCTIKTPEITVSIIK 19 1 Q8TED0;H0Y8P4;Q8TED0-3;Q8TED0-2 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 1 28675000.0 6664000.0 8771000.0 13240000.0 True False 10109775.203658337 7205746.521864209 10623108.196701856 1.0 0.712750419935819 1.0507759057647261 23.269247582701432 -6.681569393151707 1.8962131808579985 0.8185093605549622 1.0495077312497694 0.33132183019847594 0.12170189376103314 0.43507139847815574 3.025836209634742 0.05147319218054534 0.13548963626402252 2.0817597475010502e-07 6.681569393151707 0.23099837069480722 VLDPTCTIK(ub)TPEITVSIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLDPTCTIKTPEITVSIIK 19 1 Q8TED0;H0Y8P4;Q8TED0-3;Q8TED0-2 Q8TED0 UTP15 U3 small nucleolar RNA-associated protein 15 homolog 1 21520800.0 6664000.0 8396000.0 6460800.0 True False 8626679.367078565 7928755.21932283 5285000.693406155 1.0 0.9190970107896699 0.6126344180096642 23.04037390479388 -6.946127580234125 0.5998631392320131 1.0034529042392168 0.5125945454867243 0.998861194471492 0.00563017182507625 0.08507922376951498 0.04269385680894763 0.005779257025970057 0.025753128734217614 1.132067753241152e-07 6.946127580234125 -0.4908583587524925 VLDSGAPIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLDSGAPIK 9 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 12534800.0 3750000.0 1827700.0 6957100.0 False True 3630958.3026462225 2557510.141329589 5134826.80147376 1.0 0.70436230002027 1.414179501243935 21.791918931874598 -6.793580058068729 1.4819111522531943 0.8355289989305281 1.4224994246305476 0.8127187020890698 0.12598751953464346 0.23006841576096965 0.9979908538433058 0.06690351744290043 0.15624500600409297 1.6084958396051674e-07 6.793580058068729 0.5869704257000194 VLDSGAPIK(ub)IPVGPETLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLDSGAPIKIPVGPETLGR 19 1 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 1 8851000.0 2344700.0 2370700.0 4135600.0 True False 3073924.406107096 2017000.8009162238 3707687.783476406 1.0 0.6561647374636028 1.20617402825853 21.551650256058977 -6.737682721849026 1.69522325407748 0.7948712908672548 1.20633341925085 0.5944721594669584 0.14447490180191264 0.3220271137664413 1.8161914589688761 0.06744691357133793 0.16592880328067203 1.8294362408920193e-07 6.737682721849026 0.4114621283835951 VLDSGAPIK(ub)IPVGPETLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLDSGAPIKIPVGPETLGR 19 1 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 1 16784100.0 5016700.0 3321500.0 8445900.0 True False 4857447.604502744 4647792.271393679 6233665.41843113 1.0 0.9568383747639976 1.2833211855239908 22.211767003398975 -6.8736091488860005 1.1148759288755525 0.9749683714294495 1.3037960825453867 0.9681520075444489 0.025842486924911444 0.1334389594197213 0.30781012365698385 0.017947484149021087 0.04277700203225914 1.337798951116722e-07 6.8736091488860005 0.3288277111159372 VLDSGAPIK(ub)IPVGPETLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLDSGAPIKIPVGPETLGR 19 1 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 1 15150200.0 5016700.0 5315900.0 4817600.0 True False 4171608.32749248 5287262.191576469 5824937.885934357 1.0 1.2674397442184124 1.3963290483303066 21.99217227883325 -12.694954982237345 0.10855397051103131 5.504927941982982e-14 1.6552049046903066 0.9997892575606122 0.002396212860153421 7.554175605561347 0.08682277228074152 1.8676413493991801 0.20864264867788532 2.0185755927902177e-13 12.694954982237345 1.6552049046902515 VLDSGAPIK(ub)IPVGPETLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLDSGAPIKIPVGPETLGR 19 1 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 1 28187400.0 5436600.0 3310800.0 19440000.0 True False 7037785.871407462 3126551.069572901 15902119.47124438 1.0 0.44425208818517703 2.259534427702639 22.746690189271643 -6.824527660632519 1.3521395136142809 0.701750092646001 2.3031599184905276 0.8944958844619044 0.2466717477345468 0.1876562982672251 0.6728724784802613 0.14331064472315339 0.32998299275102727 1.4978638496200582e-07 6.824527660632519 1.6014098258445266 up VLDSGAPIKIPVGPETLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLDSGAPIKIPVGPETLGR 19 1 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 26815500.0 8197800.0 2523700.0 16094000.0 False True 7937565.3262488395 3531426.5709216404 11878498.59034924 1.0 0.4449004733533996 1.496491443171885 22.920265129541054 -6.763279873534291 1.6000161859086737 0.6788812008553804 1.5009816693772284 0.7042287452826999 0.23360058090378072 0.27745480273440454 1.4006016234234293 0.11515226424465849 0.27585229234645703 1.7247260640295828e-07 6.763279873534291 0.822100468521848 VLDVNLMGTFNVIR ddPTM_RPMI8226_Bortezomib_8h_R1 2 VLDVNLMGTFNVIR 14 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 259386900.0 74934900.0 75004000.0 109448000.0 False True 113681721.77500248 61618950.1910733 87815554.8272374 1.0 0.5420304093654457 0.7724685504063785 26.760425069403126 -10.25949262925802 4.801002646680263 1.0000954553502648 0.6572494798853349 0.7468198734600691 0.09407597713961838 9.614640722251805e-05 1.48296996357355e-05 0.09111393736032228 0.030362891061378575 5.501832580100234e-11 10.25949262925802 -0.3428459754649299 VLDVNLMGTFNVIR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VLDVNLMGTFNVIR 14 0 Q99714;Q99714-2;Q5H928 Q99714 HSD17B10 3-hydroxyacyl-CoA dehydrogenase type-2 0 198699500.0 74934900.0 62520200.0 61244400.0 False True 97004705.23770936 59040895.91032731 50098547.62061117 1.0 0.6086395063584596 0.5164548203908772 26.531551391495576 -13.999999999999984 0.20311347573571564 3.2017683940927837 0.45838955855623187 0.9994873275275535 0.004746342076542223 12.594171450425153 0.14288896193665832 11.030966272221109 0.057364326799796514 1.0000000000000368e-14 13.999999999999984 -2.743378835536552 VLEACSIACNK(ub)NTCPGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLEACSIACNKNTCPGDR 18 1 P34896-2;P34896;P34896-3;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 1 9460000.0 1874500.0 3996200.0 3589300.0 True False 2457487.65268382 3399982.5370655945 3217913.6669967747 1.0 1.3835196825312537 1.3094322827960068 21.22875273728105 -10.088433809155925 4.393677766774361 0.9999662311110739 1.3464759826911814 0.9668441482019603 0.03024605438240325 4536092.330503578 5207718.33750191 1197.0678427910702 0.010354028377849447 8.157671087651507e-11 10.088433809155925 0.34650975158010755 VLEACSIACNK(ub)NTCPGDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLEACSIACNKNTCPGDR 18 1 P34896-2;P34896;P34896-3;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 1 81516200.0 5467200.0 11573000.0 64476000.0 True False 8294142.105858478 9507707.729738282 51732290.33916524 1.0 1.1463159912611836 6.237208101682354 22.98366133487779 -6.913047581678392 0.8747304408218687 0.8571600727938269 6.939866998805683 0.9920216008461957 0.21750676746708908 0.10243688694334867 0.12809312489213773 0.18080384563030902 0.5102913698741731 1.221665806071963e-07 6.913047581678392 6.082706926011856 up VLEACSIACNK(ub)NTCPGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLEACSIACNKNTCPGDR 18 1 P34896-2;P34896;P34896-3;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 1 10546300.0 1874500.0 2574800.0 6097000.0 True False 2567553.3064577747 2461036.822275022 4657014.17165657 1.0 0.9585144020516154 1.813794541263659 21.29196279880394 -6.895504347599284 0.9892783488594082 0.9599227406359742 1.8957980871250126 0.9841929140046887 0.049507102071796025 0.11478974490642699 0.19668124979896826 0.0378284604075735 0.09637817455208332 1.2720250161391145e-07 6.895504347599284 0.9358753464890385 VLEACSIACNK(ub)NTCPGDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLEACSIACNKNTCPGDR 18 1 P34896-2;P34896;P34896-3;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 1 50778600.0 5467200.0 6282400.0 39029000.0 True False 7077398.174623643 5932778.917326565 31926122.471357927 1.0 0.838271179739305 4.510997075991937 22.75478765697024 -6.896600354940272 0.9825227967986867 0.8327343164708559 4.870950030527061 0.9847973000747356 0.20893135206854072 0.11395070830168745 0.1918741109636888 0.1604532593771658 0.4107821421439625 1.268818917234635e-07 6.896600354940272 4.038215714056205 up VLEAK(ub)ELALQPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLEAKELALQPK 12 1 P41250 P41250 GARS Glycine--tRNA ligase 1 8184200.0 4447700.0 0.0 3736500.0 True False 5830977.771588076 0.0 3349882.823038882 1.0 0.0 0.5744976150246129 22.47530639236293 -9.986084123658475 6.207572236212135 1.0000003622279086 0.2872488075122686 0.672376855443295 0.23453766920950123 1.175853053459739e-06 1.918844043088379e-07 0.22709023677320664 0.07569670724220513 1.0325613773070412e-10 9.986084123658475 -0.71275155471564 VLEAK(ub)ELALQPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLEAKELALQPK 12 1 P41250 P41250 GARS Glycine--tRNA ligase 1 20130700.0 7810900.0 5520400.0 6799400.0 True False 7562947.254970502 7724724.508505698 5018433.162372357 1.0 1.0213907684506027 0.6635552243305881 22.850517126724153 -6.892693777227119 1.0062833993647278 1.0180037130082975 0.6310999939270399 0.9825681309524716 0.021636552865228826 0.11698579939310935 0.20928529815112348 0.016321936174247324 0.041107107086397955 1.2802837191331532e-07 6.892693777227119 -0.38690371908125765 VLEAK(ub)ELALQPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLEAKELALQPK 12 1 P41250 P41250 GARS Glycine--tRNA ligase 1 18233400.0 7810900.0 5817000.0 4605500.0 True False 6495109.431540862 5785662.66641591 5568488.756573948 1.0 0.8907721613311377 0.8573356331046316 22.63092240215843 -13.999999992091963 0.16581429509893353 1.5450659084941967 0.8264869937110483 0.9995222865837035 0.0013315074593106032 12.053497627955965 0.12885447422437182 2.112678375698926 0.028335297448522864 1.000000018208928e-14 13.999999992091963 -0.7185789147831484 VLEALLPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLEALLPLK 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 4950260.0 650660.0 2553700.0 1745900.0 False True 853021.5610004023 2172697.9142446336 1565251.0158553708 1.0 2.547060957869046 1.834948947855062 19.702222682047477 -10.080838474089733 4.642653848634287 0.9999364440165215 2.1910049528936115 0.78856831435447 0.2907185108135881 100990641.51863572 9.417918667978203 69474.9575925381 0.09952067889459364 8.301594689515581e-11 10.080838474089733 1.19106850887709 VLEALLPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLEALLPLK 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 6318460.0 650660.0 2378900.0 3288900.0 False True 891226.5854253483 2273792.3320296905 2512129.5570217017 1.0 2.5513066701713085 2.818732742159794 19.76543274357037 -10.304242506727963 0.3828024818590479 8.651792219421824e-23 2.852496813252052 0.9991050566859162 0.02398614072728767 1.710747095758759 0.17790732418002286 1.8331648395860962 0.07144825350896396 4.963151054885244e-11 10.304242506727963 2.852496813252052 VLEALLPLK(ub)GLEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLEALLPLKGLEER 14 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 11357400.0 1870500.0 3772500.0 5714400.0 True False 1811122.001359933 5278878.923327602 4217627.211674646 1.0 2.914700897766028 2.3287372184246666 20.788452302154816 -10.042671081576614 5.121768349721045 0.9999797344373563 2.621719058101909 0.9108169124621401 0.23921867038787234 5.535826482432056e-05 1.0346971679647856e-05 0.231625363725569 0.07720749387289506 9.064188287775897e-11 10.042671081576614 1.6217393236645528 VLEALLPLK(ub)GLEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLEALLPLKGLEER 14 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 29129300.0 2682400.0 5148900.0 21298000.0 True False 4069396.9097078494 4230038.566460686 17088440.964754988 1.0 1.0394755439975918 4.199256387104742 21.956383570242306 -6.9096267385843255 0.8982823931788452 0.9010084405118347 4.6043485633703245 0.9907797291626225 0.14393024239317034 0.10466510851787751 0.14011349335568218 0.11762059704981095 0.32384859817556993 1.2313265997217394e-07 6.9096267385843255 3.70334012285849 up VLEALLPLK(ub)GLEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLEALLPLKGLEER 14 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 10366600.0 1870500.0 3372700.0 5123400.0 True False 1555403.6272000873 3354530.595671468 6194679.252074918 1.0 2.156694594900762 3.982682786477798 20.568857577589093 -6.964394233650073 0.36830053498314413 0.8568467287127236 5.3459212571058705 0.9999001089716674 0.012271820913374873 0.0781671274783955 0.015588407755223594 0.02413189218718227 0.1552229685622731 1.0854398611512611e-07 6.964394233650073 4.489074528393147 VLEALLPLK(ub)GLEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLEALLPLKGLEER 14 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 29361100.0 2682400.0 5389700.0 21289000.0 True False 3472419.678008933 5089758.457072932 17414620.44358653 1.0 1.465767081469649 5.015125491274712 21.727509892334755 -6.931012171308523 0.7384371745108713 0.9480011197407789 5.762933267436002 0.9967334479072986 0.1024810728371394 0.0921156898628031 0.07513052582885628 0.09393360160056834 0.31938703377233735 1.1721625146782307e-07 6.931012171308523 4.814932147695223 up VLEDGK(ub)QQVQVVGLQEHLVNSADDVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLEDGKQQVQVVGLQEHLVNSADDVIK 27 1 Q99661;Q99661-2 Q99661 KIF2C Kinesin-like protein KIF2C 1 32521400.0 3569300.0 6831100.0 22121000.0 True False 4620529.211421594 6450943.279980495 18095204.98062744 1.0 1.396148143384584 3.9162624350252955 22.139626669227134 -6.934610420336239 0.7079338331117413 0.9674373288683837 4.500099655377493 0.997369163486759 0.066244850777984 0.09031384093972764 0.06646605348553357 0.06210227821591104 0.22253116619210278 1.1624909475216717e-07 6.934610420336239 3.5326623265091097 up VLEDGK(ub)QQVQVVGLQER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLEDGKQQVQVVGLQER 17 1 O00139-2;O00139-1;O00139-5;O00139;O00139-4;H0Y8H2 O00139-2 KIF2A Kinesin-like protein KIF2A 1 10287950.0 5241700.0 4276700.0 769550.0 True False 4358705.796682551 4253660.56824152 930459.3470028195 1.0 0.9758999039299735 0.21347147304849076 22.055468397473216 -6.913636096813733 0.8706126777781894 1.0209799728293871 0.1068769521358876 0.9922225772528501 0.032209099802164035 0.10206298216441237 0.12609086221111676 0.0268534131673727 0.07613448024703323 1.220011440364902e-07 6.913636096813733 -0.9141030206934995 down VLEDGK(ub)QQVQVVGLQER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLEDGKQQVQVVGLQER 17 1 O00139-2;O00139-1;O00139-5;O00139;O00139-4;H0Y8H2 O00139-2 KIF2A Kinesin-like protein KIF2A 1 15243000.0 5926500.0 3596700.0 5719800.0 True False 7671971.078780173 3396540.483246598 4678855.0901040975 1.0 0.44272071001949614 0.6098634942779301 22.87116585112716 -10.895300320464823 11.289281505105933 1.0311549077581577 0.5262921021487131 0.91460204906887 0.06823575593687593 0.034444523641049704 0.00031944674241830454 0.04253152162629552 0.02202299552994951 1.2726227409573867e-11 10.895300320464823 -0.5048628056094445 VLEDSDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLEDSDLK 8 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 20134360.0 818260.0 11620000.0 7696100.0 False True 1072746.7840411111 9886341.29440525 6899781.398204075 1.0 9.215913243908988 6.431882622115279 20.032878145400083 -9.432278352796441 9.82460853567038 1.0000015629068115 7.82389793301214 0.88901749073381 1.1365757419467089 0.0 0.0 1.1004846808701412 0.3668282433551876 3.6959122138039417e-10 9.432278352796441 6.823896370105329 VLEDSDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLEDSDLK 8 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 19705600.0 6669000.0 1917600.0 11119000.0 False True 6457296.245426046 2683307.6801518914 8206600.337150074 1.0 0.41554662790213204 1.2709034904451113 22.62249878535214 -6.7227789908684565 1.7494666819584204 0.6454826117098272 1.2697693482122494 0.5255373232904609 0.24585984225288202 0.3499428153462277 2.0946559472230506 0.11152616796130162 0.2790455009027044 1.893306862874473e-07 6.7227789908684565 0.6242867365024222 VLEDSDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLEDSDLK 8 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 19236160.0 818260.0 9901100.0 8516800.0 False True 1120792.8346450462 9463636.663440732 6505307.249001917 1.0 8.4436983989444 5.804201318847779 20.096088206922975 -9.43919736900378 9.562619977978065 0.9999999417032571 7.123949858896101 0.877709880302644 1.0775701706338474 0.0 0.0 1.0433528313086742 0.34778427710289134 3.637496892652856e-10 9.43919736900378 6.123949917192844 VLEDSDLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLEDSDLKK 9 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 9921070.0 2069450.0 1919420.0 5932200.0 True False 2003756.4425096572 2685854.415643069 4378378.857814702 1.0 1.340409621979356 2.185085355149694 20.93427572828755 -6.955622151069238 0.4932809531346445 0.9820528125007039 2.5794599751226817 0.9995717946725887 0.010309205840272636 0.08130371701533586 0.027204575136444576 0.012248484130655523 0.06966755735130188 1.1075869980623062e-07 6.955622151069238 1.5974071626219777 up VLEDSDLK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLEDSDLKK 9 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 30802400.0 1209800.0 7358600.0 22234000.0 True False 1835355.0482271702 6045400.336995781 17839440.1544916 1.0 3.293858778352032 9.719885082574786 20.807627747797838 -6.952979592681842 0.5251161894535374 0.8949647670166053 12.408068228637736 0.9994148366976392 0.0892788005813728 0.08231091986902772 0.031178229045747803 0.10033718274872268 0.531081946067947 1.1143468950614017e-07 6.952979592681842 11.513103461621132 VLEDSDLK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLEDSDLKK 9 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 7687950.0 2069450.0 3092400.0 2526100.0 True False 1720839.367179482 3075740.6274066623 3054295.8306332584 1.0 1.7873490612014022 1.7748872375225584 20.714681003721825 -10.102606991581629 4.963371343453498 0.9999725450534557 1.7811181493653545 0.9998091427441361 0.005087518224635335 1.5456856163345954e-06 2.7947008649216076e-07 0.004926140996799228 0.0016419894447916791 7.895743081052769e-11 10.102606991581629 0.7811456043118988 VLEDSDLK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLEDSDLKK 9 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 1 19556000.0 1209800.0 3215200.0 15131000.0 True False 1566109.9487232373 3036271.293612054 12377313.257170739 1.0 1.9387344394864217 7.903221141824223 20.578754069890287 -6.934634725768138 0.7077130267995044 0.9229955022997026 9.285974992298545 0.9973733323585605 0.15667768750386357 0.09030170362216379 0.06640704815182685 0.14690404177048572 0.5266102278112158 1.162425890158282e-07 6.934634725768138 8.362979489998843 VLEEEENK(ub)PNPVTQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLEEEENKPNPVTQR 15 1 P04035-2;P04035;P04035-3 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 49736500.0 9453500.0 12592000.0 27691000.0 True False 12393630.047824236 10713322.683231555 24825800.95082823 1.0 0.8644216942002665 2.003109730969138 23.56309547355953 -6.8771758598452 1.0953717598306671 0.9187248732549272 2.0795794907064487 0.9713377117606156 0.08597900689415418 0.13016384533789144 0.2876212881057875 0.06060829108451054 0.14557745925662163 1.3268570617065326e-07 6.8771758598452 1.1608546174515215 up VLEEEENK(ub)PNPVTQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLEEEENKPNPVTQR 15 1 P04035-2;P04035;P04035-3 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 51122700.0 7030700.0 10816000.0 33276000.0 True False 6807514.276910614 15134885.204694862 24560017.34139812 1.0 2.2232616178314317 3.607780511705948 22.69869667225708 -6.969515084827739 0.26951519740196556 0.6537895456605127 5.218848493781582 0.999978350099004 0.004956780339951438 0.0764603638987648 0.009591729670814482 0.02722047657650042 0.12885402505801732 1.0727163873507145e-07 6.969515084827739 4.565058948121069 VLEEEENK(ub)PNPVTQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLEEEENKPNPVTQR 15 1 P04035-2;P04035;P04035-3 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 285481000.0 10371000.0 132340000.0 142770000.0 True False 15733565.221659735 108722893.02286056 114551446.92168595 1.0 6.910251522216106 7.2807049964738955 23.907342286319437 -9.843991774829375 0.6850796958223123 1.3447926198615603e-21 7.221590638778091 0.9996120932233603 0.056671658578053695 1.1187996312172768 0.3352401293718899 2.672846862077911 0.05830461938160596 1.4322150239594005e-10 9.843991774829375 7.221590638778091 VLEEEENK(ub)PNPVTQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLEEEENKPNPVTQR 15 1 P04035-2;P04035;P04035-3 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 56668300.0 9453500.0 8699800.0 38515000.0 True False 12948714.421231588 8315414.0696086 29418550.24132405 1.0 0.6421806674471162 2.2719282613173863 23.626305535082423 -6.849156860912664 1.2391695789056376 0.8091888847210014 2.3360229623413096 0.9390722833684737 0.17262629250346034 0.1583817809004542 0.4684296896280643 0.10903340279161172 0.2521751790558004 1.4152825079699604e-07 6.849156860912664 1.5268340776203082 up VLEEEENK(ub)PNPVTQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLEEEENKPNPVTQR 15 1 P04035-2;P04035;P04035-3 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 36429700.0 7030700.0 15839000.0 13560000.0 True False 5846338.562820461 15753672.163204642 16395333.305643858 1.0 2.694621940540605 2.8043762997082102 22.479101947691355 -10.526202411574777 0.5364333418289362 4.364791892216814e-12 2.7966273554569003 0.9997103065487354 0.014057781563891321 1.948176715357647 0.2571606312219755 2.6978147967289603 0.020907287195735404 2.9771285560981364e-11 10.526202411574777 2.7966273554525354 VLEEEENK(ub)PNPVTQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLEEEENKPNPVTQR 15 1 P04035-2;P04035;P04035-3 P04035-2 HMGCR 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 212683000.0 10371000.0 111390000.0 90922000.0 True False 13425463.942972941 105191048.58032043 74375128.93850212 1.0 7.835189087478706 5.539855401230362 23.678468608411887 -9.643736056905551 10.730801018648963 1.0000000000026228 6.687522244354237 0.8911435033705145 0.9370660534550033 0.0 0.0 0.9073103048318842 0.3024367682772947 2.271244784789704e-10 9.643736056905551 5.687522244351614 VLEGMEVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLEGMEVVR 9 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 106621400.0 9314400.0 48161000.0 49146000.0 False True 12211268.60077792 40975566.53010761 44060843.36172055 1.0 3.3555536177049823 3.608211792091253 23.541709750612203 -10.164309978173305 0.49547180681880243 3.195259095740378e-20 3.6016374045708313 0.999364144590058 0.02961661656367226 1.4746942707407675 0.22982850620985656 2.145954113813749 0.0516291990759072 6.849991330288479e-11 10.164309978173305 3.6016374045708313 VLEGMEVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLEGMEVVR 9 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 13971800.0 4581600.0 2489700.0 6900500.0 False True 4436159.615841042 3483850.1936139846 5093052.039437368 1.0 0.7853302169681937 1.148076823306951 22.08087984484172 -6.746355660336558 1.6632053822139097 0.8732213019251185 1.1486072504739184 0.6331806277745625 0.09019441863825411 0.3064521311667944 1.6666927920626213 0.04285902308094444 0.10445655988398023 1.7932644525897574e-07 6.746355660336558 0.27538594854879994 VLEILQVK(ub)DAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLEILQVKDAK 11 1 Q9NXG0-3;Q9NXG0;Q9NXG0-2 Q9NXG0-3 CNTLN Centlein 1 4092150.0 1167900.0 1926300.0 997950.0 True False 1531128.20995969 1638903.5486585884 894691.7070123529 1.0 1.0703894931840723 0.5843349375921351 20.546163662174038 -6.870134009971603 1.1333202163873164 1.0398463413047456 0.5557884591815521 0.964820166840125 0.04022683972086683 0.13672987528841504 0.32813983520545204 0.0275433243228422 0.065228414875838 1.3485466981885414e-07 6.870134009971603 -0.48405788212319356 VLEILQVK(ub)DAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLEILQVKDAK 11 1 Q9NXG0-3;Q9NXG0;Q9NXG0-2 Q9NXG0-3 CNTLN Centlein 1 6349300.0 2122000.0 2428200.0 1799100.0 True False 2054638.271524073 3397792.9228957207 1327861.7381569112 1.0 1.6537183065198786 0.646275189438548 20.970452992518755 -6.731582186727065 1.717754387137656 1.3927142567280504 0.6467306241475629 0.5664778270066204 0.2747740901945641 0.33326913963265914 1.9272802919875127 0.12673410701416532 0.3138851470449332 1.855315672686275e-07 6.731582186727065 -0.7459836325804875 VLEILQVK(ub)DAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLEILQVKDAK 11 1 Q9NXG0-3;Q9NXG0;Q9NXG0-2 Q9NXG0-3 CNTLN Centlein 1 4289300.0 1167900.0 1326600.0 1794800.0 True False 1599704.1913107713 1267986.4255204438 1370905.205066298 1.0 0.7926380592161083 0.8569741909240113 20.60937372369693 -10.097975653748971 6.828159403265389 1.000000121437522 0.8248061250700597 0.9081477405353717 0.02626511578480964 4.85420129238897e-08 6.4378374142211635e-09 0.025431106436937266 0.00847702966839806 7.980394235572014e-11 10.097975653748971 -0.17519399636746236 VLEILQVK(ub)DAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLEILQVKDAK 11 1 Q9NXG0-3;Q9NXG0;Q9NXG0-2 Q9NXG0-3 CNTLN Centlein 1 5571000.0 2122000.0 2331600.0 1117400.0 True False 1764537.0205392065 2319039.208013634 1351043.1737261394 1.0 1.314247976109327 0.7656643969494549 20.75085826795303 -6.751341047533008 1.6448563804377163 1.1844809870400042 0.7644593811611915 0.6547463645562478 0.1320586478412426 0.297704618994714 1.585131178326873 0.06341132629813032 0.1537309608622168 1.772796772831826e-07 6.751341047533008 -0.42002160587881265 VLELK(ub)EHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLELKEHK 8 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 1 2623990.0 758970.0 1278600.0 586420.0 True False 995017.0198759354 1087837.863943763 525742.8837378464 1.0 1.093285684780951 0.5283757696962803 19.924361677762047 -6.864500188807337 1.1628077200785367 1.051355825627611 0.49857601331594104 0.9588755245646158 0.05014306377181033 0.14224017833448474 0.3629389125575308 0.03356648089563382 0.07879421464516122 1.3661544817615047e-07 6.864500188807337 -0.55277981231167 VLELK(ub)EHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLELKEHK 8 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 1 2802690.0 812870.0 1225900.0 763920.0 True False 787065.8867925416 1715408.2629840444 563826.4348912386 1.0 2.179497665658834 0.7163649757315101 19.58612488598933 -6.692186316955902 1.8588124494012102 1.7379680951732455 0.721313984278718 0.3805619362328265 0.4986282259774796 0.4120103519075301 2.761766792154588 0.2144701951451276 0.5569271105204944 2.0314852951446656e-07 6.692186316955902 -1.0166541108945275 VLELK(ub)EHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLELKEHK 8 1 A0A087WUK2;O14979-3;O14979-2;O14979 A0A087WUK2 HNRNPDL Heterogeneous nuclear ribonucleoprotein D-like 1 3257890.0 812870.0 1568600.0 876420.0 True False 675937.4212467978 1560149.6404572765 1059675.3698917706 1.0 2.308127337556646 1.567712241670465 19.366530161423608 -10.314672899715768 5.382872784950143 0.9998080725459283 1.9379197896135933 0.6814815983746758 0.3022731971293035 0.0006963681249767051 8.865929557667996e-05 0.2927329733392042 0.09755825487386934 4.8453717207043674e-11 10.314672899715768 0.938111717067665 VLELVSITANK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLELVSITANK 11 0 P34897;P34897-3;P34897-2;H0YIZ0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 36938000.0 12181000.0 13223000.0 11534000.0 False True 15969408.96097178 11250179.942850292 10340572.321940456 1.0 0.7044831759487791 0.64752379672987 23.928807582793237 -13.999999999999996 0.2314902200474764 2.8784680883515477 0.6202194339747183 0.9995118638302416 0.0034133431297147755 13.338125764742303 0.15233082949309565 11.525839446064994 0.029295286263230528 1.0000000000000082e-14 13.999999999999996 -2.258248654376829 VLELVSITANK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLELVSITANK 11 0 P34897;P34897-3;P34897-2;H0YIZ0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 43459500.0 17301000.0 9759500.0 16399000.0 False True 16751789.225088596 13656519.245120142 12103609.94054536 1.0 0.8152274996790927 0.7225263986976499 23.997811859382267 -13.999999999999522 0.08938100459666236 1.948697036053123 0.4880344713131583 0.9998453020638134 0.0014345367265337907 12.16929666854959 0.08671341547093503 2.1983097236517475 0.21080458759887521 1.0000000000011003e-14 13.999999999999522 -1.4606625647399647 VLELVSITANK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLELVSITANK 11 0 P34897;P34897-3;P34897-2;H0YIZ0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 70536000.0 12160000.0 39087000.0 19289000.0 False True 18447609.01507884 32111619.46187511 15476520.695330963 1.0 1.740692760542978 0.8389445311140675 24.136930505666832 -6.688467486360685 1.8721642361702369 1.465037604452452 0.8421419177347985 0.36316349581146634 0.3133594404291976 0.4199495660040445 2.852667468107393 0.13396993807467755 0.3495034652366417 2.0489554401276793e-07 6.688467486360685 -0.6228956867176535 VLELVSITANK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLELVSITANK 11 0 P34897;P34897-3;P34897-2;H0YIZ0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 58796000.0 12181000.0 17036000.0 29579000.0 False True 16684644.879147582 16283293.189481616 22593049.398627162 1.0 0.9759448467394368 1.35412228203094 23.992017644316128 -6.8917324087892995 1.012097670343075 0.9805158920507926 1.3877724758460515 0.9819834842878818 0.023205439656710458 0.11774804047579225 0.2137367071398422 0.017429386745176818 0.04373086888949307 1.28312093607378e-07 6.8917324087892995 0.40725658379525886 VLELVSITANK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLELVSITANK 11 0 P34897;P34897-3;P34897-2;H0YIZ0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 34315200.0 17301000.0 9278200.0 7736000.0 False True 14386548.064254865 9228216.495021487 9353561.832777346 1.0 0.6414475837987931 0.6501602601959404 23.778217134816543 -10.478048997046125 6.090808568458172 1.0002344985204163 0.6458039219973667 0.9995463916553814 0.003556935244500389 1.1333799039876917e-05 9.7124251652359e-07 0.0034462303982459364 0.001147995913790669 3.326220248041297e-11 10.478048997046125 -0.35443057652304966 VLELVSITANK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLELVSITANK 11 0 P34897;P34897-3;P34897-2;H0YIZ0 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial;Serine hydroxymethyltransferase 0 47248000.0 12160000.0 21312000.0 13776000.0 False True 15741359.70943508 20125968.465246364 11268909.35369664 1.0 1.2785406620994266 0.7158790321615143 23.90805682775928 -6.7721135205119705 1.5665365121683597 1.1593311982093477 0.7124703327031549 0.7385332895029623 0.11745918831194359 0.2630170923638101 1.2741376459050524 0.05909318471352326 0.14038538756495872 1.6899991239533184e-07 6.7721135205119705 -0.44686086550619286 VLENAEGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLENAEGAR 9 0 P38646;A0A3B3ITI4;D6RJI2;D6RA73 P38646 HSPA9 Stress-70 protein, mitochondrial 0 7474100.0 3220100.0 752100.0 3501900.0 False True 3117879.6880936283 1052417.4521496857 2584647.3352518966 1.0 0.3375426756101572 0.8289759688682 21.572133828104086 -9.923648262142457 6.5194966284929246 1.000000040049251 0.5832593222393587 0.48949103719220743 0.2006268018496712 1.1696819548114027e-07 1.9091900841925892e-08 0.1942560829594105 0.06475202186387878 1.1922071932930666e-10 9.923648262142457 -0.4167407178098923 VLEQHK(ub)LNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLEQHKLNK 9 1 P26038 P26038 MSN Moesin 1 26813910.0 9387110.0 12868000.0 4558800.0 True False 12306592.11490254 10948144.55907113 4087099.1070974628 1.0 0.8896162688136537 0.3321064896713553 23.552927976838138 -6.939580540969685 0.6634535687652843 1.0063052394853549 0.1836006318893843 0.9981084520171747 0.012713763206322067 0.08795849947077658 0.05548484647125448 0.012336916823397963 0.04807310779284032 1.1492630900156897e-07 6.939580540969685 -0.8227046075959705 down VLEQHK(ub)LNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLEQHKLNK 9 1 P26038 P26038 MSN Moesin 1 24781410.0 9387110.0 9782600.0 5611700.0 True False 12857778.244109277 9350372.385267818 4286332.036589332 1.0 0.7272152472805045 0.3333649060678965 23.61613803836103 -6.965883914820193 0.3425432333677713 1.0414795908482324 0.005961203524381304 0.9999302232837368 0.0022858127474559304 0.07766227755040578 0.01380939080968842 0.005517592817550135 0.03402678263945882 1.081723052908427e-07 6.965883914820193 -1.0355183873238512 down VLEQHK(ub)LNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLEQHKLNK 9 1 P26038 P26038 MSN Moesin 1 33624080.0 14334610.0 17198970.0 2090500.0 True False 11919863.345896097 17106315.734881766 2527613.8846200984 1.0 1.4351100544094173 0.2120505756880454 23.50686436047066 -6.810527995914321 1.4123384097230063 1.2369829582417846 0.19039934804738706 0.86119469644256 0.18858929351568332 0.2060821412540907 0.8100921791547745 0.10499280697389178 0.2428094170112701 1.5469347807156603e-07 6.810527995914321 -1.0465836101943975 down VLEQHK(ub)LTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLEQHKLTK 9 1 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3 A0A2R8Y5S7 RDX Radixin 1 26881060.0 11474100.0 11765900.0 3641060.0 True False 15042656.215342456 10010473.58311899 3264318.0387137583 1.0 0.6654724697430104 0.21700409767952966 23.842556003191678 -7.337979612273991 0.4046157018796245 1.0315119035035232 6.261339317835843e-14 0.9993527176074092 0.008161275219246538 0.1062644935508137 0.03592725128538067 0.013218336059820313 0.055337545801295275 4.5921957015203185e-08 7.337979612273991 -1.0315119035034606 down VLEQHK(ub)LTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLEQHKLTK 9 1 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3 A0A2R8Y5S7 RDX Radixin 1 28492680.0 14025900.0 10966000.0 3500780.0 True False 13580655.481889503 15344780.98693453 2583820.6968511767 1.0 1.1298998790888686 0.19025743641732415 23.69504977837809 -6.871945315287944 1.123700200399963 1.0744128233804673 0.13314096794434452 0.9665890712214917 0.07598990833523477 0.1350060638285241 0.3174184923427027 0.05241595291621676 0.124538618677538 1.3429340476481573e-07 6.871945315287944 -0.9412718554361228 down VLEQHK(ub)LTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLEQHKLTK 9 1 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3 A0A2R8Y5S7 RDX Radixin 1 15726220.0 6479800.0 4475980.0 4770440.0 True False 9830330.336834516 3677206.3980086404 3827560.4430418666 1.0 0.37406742927346476 0.3893623420466241 23.228808466795982 -10.040679508515396 6.158462578841714 1.0000007642745723 0.38171488571115264 0.9995412471419939 0.006244121992504562 6.55219279075395e-08 1.0210836447447327e-08 0.006045852598890408 0.0020152817073781043 9.105849990663299e-11 10.040679508515396 -0.6182858785634197 VLEQHK(ub)LTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLEQHKLTK 9 1 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3 A0A2R8Y5S7 RDX Radixin 1 25702990.0 11474100.0 8888400.0 5340490.0 True False 15716384.845893394 8495681.097991802 4079176.252844052 1.0 0.5405620428168426 0.2595492724848818 23.90576606471457 -8.570059788013166 0.22478805395090304 1.2835725527671387 1.2934623238491694e-19 0.9995306341367262 0.006612092267614241 0.19255742218110683 0.06043509910677525 0.1546866957235656 0.11935611204060878 2.69116429394183e-09 8.570059788013166 -1.2835725527671387 down VLEQHK(ub)LTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLEQHKLTK 9 1 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3 A0A2R8Y5S7 RDX Radixin 1 26848000.0 14025900.0 12394200.0 427900.0 True False 11663157.30272426 12327429.984543918 517371.91161393834 1.0 1.0569547905921235 0.04435950730880492 23.475455053812365 -6.940681229550878 1.0724603532692834 1.0452586075851922 1.8320422625615935e-20 0.9825272756061666 0.06139966197730708 0.10275200796727164 0.22175514881655953 0.04584047076952477 0.09853668738747086 1.1463540521072002e-07 6.940681229550878 -1.0452586075851922 down VLEQHK(ub)LTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLEQHKLTK 9 1 A0A2R8Y5S7;P35241;P35241-5;A0A2R8Y7M3;P35241-3 A0A2R8Y5S7 RDX Radixin 1 13547700.0 6479800.0 4220600.0 2847300.0 True False 8388228.8359537255 3985719.899794419 2329120.6157651315 1.0 0.47515631460968005 0.27766536432363736 22.99993478888843 -13.999999999998712 0.13561348363983045 3.4991076794059275 0.019844430568971994 0.9996209866785107 0.0059342915829672825 11.932068729480225 0.11503731139325991 7.912911520970926 0.2298764860410761 1.0000000000029653e-14 13.999999999998712 -3.4792632488369555 VLEQLTGQTPVFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLEQLTGQTPVFSK 14 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 76177600.0 6297600.0 41572000.0 28308000.0 False True 8256214.586045145 35369619.64638677 25378959.70951015 1.0 4.283999559092052 3.073922006873015 22.977049037444836 -9.567478642109737 9.889814267587894 0.9999998252855177 3.678960782982534 0.8672858522871931 0.49401209202212853 0.0 0.0 0.47832515130669256 0.15944171710223082 2.70720633661481e-10 9.567478642109737 2.6789609576970164 VLEQLTGQTPVFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLEQLTGQTPVFSK 14 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 63327800.0 25039000.0 9445800.0 28843000.0 False True 24244150.650655672 13217557.199196279 21288153.028547503 1.0 0.5451854094479823 0.8780737809831987 24.531133376656822 -9.80461490120936 6.698333115025643 1.0000000028370244 0.7116295952155642 0.5001398018270393 0.1359011085946475 5.799575603835605e-09 1.0245426783268783e-09 0.13158568355989575 0.04386189419316873 1.5681409600339897e-10 9.80461490120936 -0.28837040762146016 VLEQLTGQTPVFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLEQLTGQTPVFSK 14 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 56724600.0 6297600.0 22440000.0 27987000.0 False True 8625992.906240854 21448526.600843363 21377047.01035797 1.0 2.48649944811866 2.4782129133090063 23.040259098967727 -10.051181088267862 4.689391921832859 0.9999473991523858 2.4823561807569967 0.9999765634776795 0.003382963815730218 885741.9382065636 0.03804505023303377 503.7427113788746 0.0012380379645534688 8.888304239384312e-11 10.051181088267862 1.4824087816046108 VLEQLTGQTPVFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLEQLTGQTPVFSK 14 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 32070000.0 25039000.0 3778800.0 3252200.0 False True 20821037.91577816 3758442.854366928 3932219.983526179 1.0 0.1805117914663987 0.18885801944322608 24.311538652091098 -9.969560020264343 6.492006862816376 1.0000001666103755 0.18468490548451785 0.9999214116990833 0.003407333303415879 8.217692176049443e-09 1.2986906069370685e-09 0.0032991369484048475 0.001099712094917605 1.072605401631146e-10 9.969560020264343 -0.8153152611258576 VLEQLTGQTPVFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLEQLTGQTPVFSK 14 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 0 12251800.0 4172300.0 3415500.0 4664000.0 False True 5401124.598328609 3225424.4225342055 3815199.856681265 1.0 0.5971764516471849 0.7063713838154905 22.364828399472504 -10.18680332779112 7.796490820553369 1.0000001591405692 0.6517739177313402 0.9313181905314911 0.044578644385028225 1.2324658322937034e-07 1.2869403617527377e-08 0.04316310611998292 0.014387695608309752 6.504241711700392e-11 10.18680332779112 -0.348226241409229 VLEQLTGQTPVFSK(ub)AR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLEQLTGQTPVFSKAR 16 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 212691200.0 5239500.0 173599500.0 33852200.0 True False 6869035.23939018 147699131.28555098 30349499.077231884 1.0 21.50216531698321 4.418305922088449 22.71167605510898 -9.928554738279873 13.023753930049995 1.0000000000259288 12.960235617025623 0.3952226073832281 6.974456392490791 0.0 0.0 6.752988364241673 2.2509961214138903 1.178813936705216e-10 9.928554738279873 11.960235616999693 VLEQLTGQTPVFSK(ub)AR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLEQLTGQTPVFSKAR 16 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 743340400.0 304777000.0 357432000.0 81131400.0 True False 295102020.9614949 500156461.583256 59880652.45017157 1.0 1.6948594928413476 0.2029150876536519 28.13663855998113 -6.780004730015611 1.5355634461299306 1.393410392479586 0.19100824310345335 0.767606421458393 0.29385198479025987 0.25050526050082694 1.1666630254267858 0.15071707070369414 0.355670505117381 1.6595688325377854e-07 6.780004730015611 -1.2024021493761325 VLEQLTGQTPVFSK(ub)AR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLEQLTGQTPVFSKAR 16 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 339012900.0 67051900.0 40677000.0 231284000.0 True False 101722634.45050682 33417871.53914841 185570616.02462143 1.0 0.32851952487927244 1.8242804762878104 26.600065490174526 -6.784630536193903 1.5174789497478918 0.6220831433797349 1.837976558029661 0.7835619263098632 0.2845820134474487 0.24343385834849424 1.107385255597916 0.1476560660886296 0.3471341777363488 1.641986052608783e-07 6.784630536193903 1.215893414649926 VLEQLTGQTPVFSK(ub)AR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLEQLTGQTPVFSKAR 16 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 253583500.0 5239500.0 207402000.0 40942000.0 True False 7176684.742163526 198238293.85330242 31272342.82695808 1.0 27.62254452792646 4.357491509029353 22.774886116631873 -9.835843330737603 10.394161612607324 1.0000005584841132 15.990018018477913 0.3563013941711456 9.497918122515884 0.0 2.159390219528395e-16 9.196319266929128 3.0654398926788025 1.4593406141502287e-10 9.835843330737603 14.990017459993801 VLEQLTGQTPVFSK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLEQLTGQTPVFSKAR 16 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 815304000.0 304777000.0 481506000.0 29021000.0 True False 253435579.41040412 478912031.6065421 35089156.92205685 1.0 1.889679549811788 0.13845394953498133 27.917043835415406 -6.768599512801879 1.5798300995912211 1.5112121897782964 0.12912623099463857 0.725160624370925 0.3748216160222953 0.26870511792888213 1.3233433528358403 0.18703398379551905 0.44579016966651025 1.7037288877810435e-07 6.768599512801879 -1.3820859587836578 VLEQLTGQTPVFSK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLEQLTGQTPVFSKAR 16 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 246960500.0 67051900.0 5814600.0 174094000.0 True False 86800006.34054838 5491012.3985558115 142410678.35528916 1.0 0.06326050688305884 1.6406758980703255 26.371191812266975 -6.745837423511136 1.6653989067559176 0.44644738005081075 1.6428154274757492 0.6308282067242786 0.39356790796124763 0.307351905580659 1.6758740431565493 0.1867966921904988 0.4554651592794678 1.795405604313518e-07 6.745837423511136 1.1963680474249383 VLETLASSLHTLK(ub)FR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLETLASSLHTLKFR 15 1 A0A0B4J2G4;Q15345-3;Q15345;A0A087X0S7;A0A087WTU1 A0A0B4J2G4 LRRC41 Leucine-rich repeat-containing protein 41 1 13848100.0 3943600.0 3339100.0 6565400.0 True False 3818412.5766174993 4672420.043176459 4845724.782221876 1.0 1.223655105210101 1.2690416986093238 21.86454156260616 -13.298503362372132 0.23338651586908862 2.2623703684911383e-15 1.2909695990538588 0.9994752327257942 0.0026939201264091737 9.682876038576753 0.14948516788474783 4.49270505108523 0.02308021129846478 5.029173721746711e-14 13.298503362372132 1.2909695990538566 VLETLASSLHTLK(ub)FR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLETLASSLHTLKFR 15 1 A0A0B4J2G4;Q15345-3;Q15345;A0A087X0S7;A0A087WTU1 A0A0B4J2G4 LRRC41 Leucine-rich repeat-containing protein 41 1 21019900.0 3187800.0 4286100.0 13546000.0 True False 4836125.659397058 3521211.967547855 10868627.162577283 1.0 0.7281059706762997 2.247383117818391 22.205420300642746 -6.860617172353219 1.1825065953794245 0.8522181075704974 2.321863133397639 0.9543931838346481 0.14126568009353183 0.146173064223236 0.3880263010261276 0.09314681595094469 0.21760119033033432 1.378424004944747e-07 6.860617172353219 1.4696450258271416 up VLETLASSLHTLK(ub)FR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLETLASSLHTLKFR 15 1 A0A0B4J2G4;Q15345-3;Q15345;A0A087X0S7;A0A087WTU1 A0A0B4J2G4 LRRC41 Leucine-rich repeat-containing protein 41 1 20098500.0 3943600.0 5628900.0 10526000.0 True False 3279278.131101986 5598575.998450828 12726937.933274863 1.0 1.7072586632258158 3.8810181462095246 21.644946838040436 -6.9509051540730935 0.5488156836891 0.9697243691767772 4.720465418801217 0.9992704208187997 0.03311273104043148 0.08312428889665162 0.03447368983887626 0.03599470468792771 0.1802918502345724 1.1196823851190658e-07 6.9509051540730935 3.7507410496244393 VLETLASSLHTLK(ub)FR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLETLASSLHTLKFR 15 1 A0A0B4J2G4;Q15345-3;Q15345;A0A087X0S7;A0A087WTU1 A0A0B4J2G4 LRRC41 Leucine-rich repeat-containing protein 41 1 20696700.0 3187800.0 5073900.0 12435000.0 True False 4126669.940932324 4791533.004683439 10171957.5938747 1.0 1.1611137002153615 2.4649312252912057 21.976546622735196 -6.929882408901036 0.7477583797668352 0.980086648650842 2.7317971762696835 0.9965150941491919 0.03872019390828548 0.09269876191064251 0.07797991537925895 0.03525141686634831 0.11804919089660237 1.1752157173986577e-07 6.929882408901036 1.7517105276188416 up VLEVHATVFCPPLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLEVHATVFCPPLR 14 0 E7EQN5;P98171;P98171-2;A0A0B4J1X7;S4R314;H7C120 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 0 3507300.0 1449900.0 1592100.0 465300.0 False True 1900832.9408515731 1354564.8859571943 417155.21947276645 1.0 0.7126164834613763 0.2194591699814929 20.85820031225448 -7.179572391130582 0.44984352565310926 1.0179353170731964 2.0976749029550735e-13 0.9995141145943318 0.007104933581733943 0.08534671557134343 0.02948775295736327 0.009233709286745377 0.044613910809137576 6.613442909733474e-08 7.179572391130582 -1.0179353170729866 down VLEVHATVFCPPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLEVHATVFCPPLR 14 0 E7EQN5;P98171;P98171-2;A0A0B4J1X7;S4R314;H7C120 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 0 37279700.0 8965700.0 16532000.0 11782000.0 False True 13601622.380468125 13581735.43489443 9453282.535765942 1.0 0.9985378990081174 0.6950113943275487 23.69727540838264 -6.907957154059007 0.9095366950710689 1.0100156810288736 0.6574529148684868 0.9901274825102998 0.014251244654301535 0.10578436586617473 0.14621073899781575 0.01155109348545719 0.0314523746633185 1.2360693736148056e-07 6.907957154059007 -0.35256276616038684 VLEVHATVFCPPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLEVHATVFCPPLR 14 0 E7EQN5;P98171;P98171-2;A0A0B4J1X7;S4R314;H7C120 E7EQN5 ARHGAP4 Rho GTPase-activating protein 4 0 7628600.0 1449900.0 1637600.0 4541100.0 False True 1985967.2120742227 1565245.4171809745 3468585.706890214 1.0 0.7881526984255547 1.7465473174995099 20.92141037377737 -6.848734078179459 1.2411984547594013 0.8870640993884119 1.7839327175860542 0.9384457451730722 0.1019845035971003 0.15885029413428273 0.471565128260179 0.06431628127106409 0.14871514416569184 1.4166609467360482e-07 6.848734078179459 0.8968686181976423 VLFALCSLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLFALCSLLR 10 0 D6REA1;Q9H173 D6REA1 SIL1 Nucleotide exchange factor SIL1 0 8814800.0 2927600.0 2450300.0 3436900.0 False True 4441383.236229009 2013024.8207187185 2757595.208553216 1.0 0.4532427655191253 0.6208865711157531 22.082577632669842 -10.928726199224958 11.626973026564999 1.0686786529996546 0.5370646683174393 0.9104526013962088 0.06844029704167948 0.031968502588861296 0.00019596786550864174 0.017386712276725995 0.022089010887659435 1.1783486287945813e-11 10.928726199224958 -0.5316139846822153 VLFALCSLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLFALCSLLR 10 0 D6REA1;Q9H173 D6REA1 SIL1 Nucleotide exchange factor SIL1 0 8359200.0 2927600.0 2607800.0 2823800.0 False True 3789835.911623527 2462673.6375595615 2309897.374634771 1.0 0.6498100960008523 0.6094979910740344 21.85370395476229 -13.999999999999998 0.3051080046747255 4.289945067709583 0.6000944187237957 0.9996611935468509 0.003227732888982194 16.92905994174751 0.17558338631500717 35.26245363985577 0.014255937910410226 1.0000000000000041e-14 13.999999999999998 -3.6898506489857876 VLFGFLYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLFGFLYR 8 0 Q8IVD9 Q8IVD9 NUDCD3 NudC domain-containing protein 3 0 17311100.0 3952100.0 8443800.0 4915200.0 False True 5181241.372190844 7184017.953674612 4406622.253927666 1.0 1.3865437715820814 0.8504954580149897 22.304866363557103 -6.7131859889747565 1.783508749779071 1.2368538548655492 0.8516125675141007 0.48039588580091264 0.16280810016057395 0.3686960003463229 2.2879808185105386 0.07258577851607334 0.1837164833169488 1.9355928582521713e-07 6.7131859889747565 -0.38524128735144847 VLFGFLYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLFGFLYR 8 0 Q8IVD9 Q8IVD9 NUDCD3 NudC domain-containing protein 3 0 29010100.0 13668000.0 6795000.0 8547100.0 False True 13234116.821484953 9508278.935456876 6308358.102496218 1.0 0.7184672059128753 0.4766739018243289 23.65775858403326 -6.99824262981613 0.17757394130700374 1.1947184144713936 1.6975978317476954e-11 0.9999970956018652 0.0003644075133305589 0.073024398139632 0.005520640262809831 0.009499952978107766 0.026751408390978483 1.0040546925008102e-07 6.99824262981613 -1.1947184144544176 down VLFGFLYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLFGFLYR 8 0 Q8IVD9 Q8IVD9 NUDCD3 NudC domain-containing protein 3 0 39824200.0 9196200.0 10821000.0 19807000.0 False True 13951307.73227531 8889908.005141119 15892137.76828348 1.0 0.6372096563087759 1.1391145599575734 23.73389702429053 -6.712796215113754 1.7853465440039447 0.7776042101635562 1.1380300942952137 0.47834041329111565 0.15281262637817342 0.36947362388511995 2.2973979921897167 0.06807195873939394 0.1723438741984976 1.9373308083902558e-07 6.712796215113754 0.36042588413165755 VLFGFLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLFGFLYR 8 0 Q8IVD9 Q8IVD9 NUDCD3 NudC domain-containing protein 3 0 24382100.0 3952100.0 6568000.0 13862000.0 False True 5413298.171486681 6277804.042528472 10588081.09685148 1.0 1.1597003977344864 1.9559390156303955 22.368076425079995 -6.9398693356830154 0.6607855621171119 0.9910422079985911 2.1698310111266843 0.9981466438966445 0.0179997564824381 0.08782642223513931 0.05488307912025605 0.01750404141977569 0.06857026346163629 1.1484991135203975e-07 6.9398693356830154 1.1787888031280933 VLFGFLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLFGFLYR 8 0 Q8IVD9 Q8IVD9 NUDCD3 NudC domain-containing protein 3 0 24182400.0 13668000.0 6104700.0 4409700.0 False True 11365547.595065933 6071812.769411929 5331747.881850865 1.0 0.5342296724926702 0.46911491393212845 23.438163859467537 -13.999999999999998 0.27718889192686674 4.737845664516217 0.44896336369192746 0.9995989745158546 0.004734317994222506 15.248291331026115 0.16674184220694213 32.256278605550094 0.02610628480402897 1.0000000000000041e-14 13.999999999999998 -4.28888230082429 VLFGFLYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLFGFLYR 8 0 Q8IVD9 Q8IVD9 NUDCD3 NudC domain-containing protein 3 0 46323200.0 9196200.0 19328000.0 17799000.0 False True 11904662.184202852 18252379.80932251 14559764.6331625 1.0 1.533212746981002 1.2230304739333884 23.50502334638298 -10.222642764679977 4.95667250079096 0.9999469720843877 1.378121610457593 0.664584861918301 0.12663138270536836 7.422001839950001e-05 1.1640003136419142e-05 0.12262745800782825 0.04087010302688028 5.989040298299664e-11 10.222642764679977 0.3781746383732054 VLFLIPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLFLIPK 7 0 B4DR80;Q9Y6E0-2;Q9Y6E0;H0Y630;Q5JV98;Q8NBY1;B4E0Y9;Q9P289;Q9P289-2;C9JDH9;C9J6L2;C9JCC0;C9J232;H7C279;O00506-3;O00506-2;O00506 B4DR80;Q8NBY1 STK24;STK26;STK25 Serine/threonine-protein kinase 24;Serine/threonine-protein kinase 24 36 kDa subunit;Serine/threonine-protein kinase 24 12 kDa subunit;Serine/threonine-protein kinase 26;Serine/threonine-protein kinase 25 0 7450900.0 1819000.0 2274200.0 3357700.0 False True 2384726.615221059 1934898.2247621685 3010277.413332704 1.0 0.8113710864852354 1.2623155183151498 21.185392454644447 -6.793085166509082 1.4840145074215834 0.8949973400539424 1.2675257032996836 0.8111623160953345 0.08035555100509448 0.230779383996142 1.0039605122438597 0.042613469591483474 0.0995477460202658 1.6103298134888956e-07 6.793085166509082 0.37252836324574123 VLFLIPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLFLIPK 7 0 B4DR80;Q9Y6E0-2;Q9Y6E0;H0Y630;Q5JV98;Q8NBY1;B4E0Y9;Q9P289;Q9P289-2;C9JDH9;C9J6L2;C9JCC0;C9J232;H7C279;O00506-3;O00506-2;O00506 B4DR80;Q8NBY1 STK24;STK26;STK25 Serine/threonine-protein kinase 24;Serine/threonine-protein kinase 24 36 kDa subunit;Serine/threonine-protein kinase 24 12 kDa subunit;Serine/threonine-protein kinase 26;Serine/threonine-protein kinase 25 0 6567800.0 1992200.0 1228200.0 3347400.0 False True 1928958.7014751446 1718626.6649783861 2470615.5201525455 1.0 0.8909608399931477 1.280802703688356 20.879390825300714 -6.832066262501556 1.3188253873997464 0.9418171294731476 1.2917296987818891 0.9099120991802887 0.04929030611327637 0.1782768394423326 0.6057232630092982 0.029339770451947186 0.06751181852431644 1.4720878814177543e-07 6.832066262501556 0.3499125693087416 VLFLIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLFLIPK 7 0 B4DR80;Q9Y6E0-2;Q9Y6E0;H0Y630;Q5JV98;Q8NBY1;B4E0Y9;Q9P289;Q9P289-2;C9JDH9;C9J6L2;C9JCC0;C9J232;H7C279;O00506-3;O00506-2;O00506 B4DR80;Q8NBY1 STK24;STK26;STK25 Serine/threonine-protein kinase 24;Serine/threonine-protein kinase 24 36 kDa subunit;Serine/threonine-protein kinase 24 12 kDa subunit;Serine/threonine-protein kinase 26;Serine/threonine-protein kinase 25 0 8457400.0 1819000.0 3153300.0 3485100.0 False True 2491533.456626673 3013976.779431342 2661991.1578875394 1.0 1.2096874603129004 1.068414775168884 21.248602516167338 -10.080450314917059 4.685791049323266 0.9999931710349453 1.1390511177438483 0.5636481706820121 0.05767433220941328 4.114778856994534e-06 8.073790608276034e-07 0.055845673710962655 0.01861431067779091 8.309017718599999e-11 10.080450314917059 0.13905794670890292 VLFLIPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLFLIPK 7 0 B4DR80;Q9Y6E0-2;Q9Y6E0;H0Y630;Q5JV98;Q8NBY1;B4E0Y9;Q9P289;Q9P289-2;C9JDH9;C9J6L2;C9JCC0;C9J232;H7C279;O00506-3;O00506-2;O00506 B4DR80;Q8NBY1 STK24;STK26;STK25 Serine/threonine-protein kinase 24;Serine/threonine-protein kinase 24 36 kDa subunit;Serine/threonine-protein kinase 24 12 kDa subunit;Serine/threonine-protein kinase 26;Serine/threonine-protein kinase 25 0 4380610.0 1992200.0 995410.0 1393000.0 False True 1656602.5694242253 990047.5287565859 1684269.8594957162 1.0 0.5976373253487651 1.0167012236864434 20.65979610073499 -10.974474891364139 12.27532224281668 1.0937232413360876 0.8071692745189366 0.22015913029834855 0.17108212009147927 0.08181502948663717 0.0001701247378928322 0.030884235231855198 0.055216516829013025 1.0605352512022254e-11 10.974474891364139 -0.28655396681715095 VLFPATGYLSIVWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLFPATGYLSIVWK 14 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 2366310000.0 854570000.0 508640000.0 1003100000.0 False True 1296445167.4355204 417869217.977541 804836845.325652 1.0 0.3223192376150564 0.6208028426822618 30.27191404333079 -10.474420527118584 6.194564194633704 1.0002932641965263 0.4715610401489341 0.8069179340385311 0.12185542150017756 0.0004937986337091747 4.189638466121184e-05 0.1180494036486808 0.039328668176272716 3.354126770311841e-11 10.474420527118584 -0.5287322240475922 VLFPATGYLSIVWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLFPATGYLSIVWK 14 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 1948880000.0 854570000.0 370140000.0 724170000.0 False True 1106257711.093087 349541383.6207907 592378490.6116793 1.0 0.315967409868186 0.5354796487939085 30.043040365423238 -10.233571254441184 5.034426095252066 1.000079540956819 0.425723529330808 0.9012408041468938 0.08961549627865587 8.001783773780921e-05 1.2181536034966915e-05 0.08678177463956341 0.028923277053921108 5.840213791863378e-11 10.233571254441184 -0.5743560116260111 VLFSSNGGVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLFSSNGGVVK 11 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 80465000.0 13614000.0 23354000.0 43497000.0 False True 17848085.838163547 19869674.23317901 38996347.69268631 1.0 1.113266398052211 2.184903638758989 24.089266021386454 -6.927114779096777 0.7700995089990975 0.9818429672699691 2.3895736701172305 0.9959404205838971 0.03401595032062542 0.09416332272344932 0.08522165124375554 0.030474277444116772 0.09854724355843703 1.1827289325978106e-07 6.927114779096777 1.4077307028472614 up VLFSSNGGVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLFSSNGGVVK 11 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 51673700.0 10216000.0 4889700.0 36568000.0 False True 9891698.671955686 6842182.709448636 26989743.78351502 1.0 0.6917095775316282 2.7285246628098996 23.237786861306716 -6.868334855227981 1.142943190835534 0.8272982961397297 2.8440576462201856 0.9629888950439641 0.1724477968035185 0.13845743380071432 0.33909491677228887 0.11721468745934323 0.2767212627936511 1.3541449197793822e-07 6.868334855227981 2.0167593500804557 up VLFSSNGGVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLFSSNGGVVK 11 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 91252000.0 13614000.0 13141000.0 64497000.0 False True 18647463.704516508 12560387.168524172 49264136.957410894 1.0 0.6735708066015426 2.6418679632811877 24.152476082909345 -6.864293731660473 1.1637794525858534 0.8204199198908319 2.7453360346164835 0.9586530163526614 0.17513560277276283 0.1424478193824297 0.3641846844987921 0.11714722489099796 0.2749318878937356 1.366804085706782e-07 6.864293731660473 1.9249161147256517 up VLFSSNGGVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLFSSNGGVVK 11 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 28379800.0 10216000.0 6078800.0 12085000.0 False True 8495056.645536551 6046052.297852673 14611917.625273315 1.0 0.7117141827452524 1.720049463466576 23.018192136740993 -6.830277493226715 1.3265978242101997 0.84598550348956 1.7473505127978777 0.9064390759799059 0.1297054408499379 0.18047116890103426 0.6210428156327524 0.07676369515841847 0.17666016989540942 1.4781636111152728e-07 6.830277493226715 0.9013650093083176 VLFSSNGGVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLFSSNGGVVK 11 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 35949500.0 8279500.0 0.0 27670000.0 False True 10717975.96334439 0.0 22634343.91817553 1.0 0.0 2.1118114087571445 23.35352914991875 -6.7779310337910035 1.5438451160525914 0.43225411218819015 2.127492359712286 0.760027834757169 0.4225350623389102 0.2538036099215729 1.1946929846790144 0.2155922549657742 0.5096124319654303 1.6675119933731188e-07 6.7779310337910035 1.6952382475240957 VLFSSNGGVVK(ub)GFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLFSSNGGVVKGFK 14 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 P26599 PTBP1 Polypyrimidine tract-binding protein 1 1 40525500.0 11205000.0 23521500.0 5799000.0 True False 14689863.509374369 20012183.88608887 5198975.107935895 1.0 1.3623124458112257 0.353915821247635 23.808317655390717 -6.8095236842345885 1.4163969960765723 1.1975750943424766 0.3364451417907862 0.8585956958654167 0.15683563804031614 0.20746318979498615 0.8203803445778618 0.08706530975397819 0.20145665262774515 1.5505162271395794e-07 6.8095236842345885 -0.8611299525516903 down VLFSSNGGVVK(ub)GFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLFSSNGGVVKGFK 14 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 P26599 PTBP1 Polypyrimidine tract-binding protein 1 1 42982000.0 18467000.0 16930100.0 7584900.0 True False 17880775.193324722 23690377.219305143 5598187.147877468 1.0 1.3249077270514127 0.31308414133898355 24.09190594789845 -6.820270557206377 1.3705703994777734 1.1750712289106433 0.29083650452164067 0.8850563754740142 0.14300285608187044 0.19311127548053383 0.7126943852479444 0.08198880762795832 0.1889698057276375 1.51261862220052e-07 6.820270557206377 -0.8842347243890026 down VLFSSNGGVVK(ub)GFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLFSSNGGVVKGFK 14 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 P26599 PTBP1 Polypyrimidine tract-binding protein 1 1 60220200.0 27007200.0 13989000.0 19224000.0 True False 40971896.89079247 11492553.65344414 15424367.973821463 1.0 0.2804984520017875 0.3764621397670204 25.288131351552302 -10.76889863825116 7.115187043032915 1.0152310325330334 0.32848029588440397 0.9849146220711961 0.03917701147676426 0.009112555531382766 0.00029597547712322295 0.03651810984296936 0.0126443260836404 1.702555828430426e-11 10.76889863825116 -0.6867507366486294 VLFSSNGGVVK(ub)GFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLFSSNGGVVKGFK 14 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 P26599 PTBP1 Polypyrimidine tract-binding protein 1 1 35922000.0 11205000.0 18633000.0 6084000.0 True False 15347791.303739352 17809732.44890881 4647084.503913164 1.0 1.1604101265417668 0.30278522895870646 23.871527716913608 -6.858360652894364 1.1940669639653527 1.086674914186883 0.26255129995743054 0.9516108025079335 0.0818934023447373 0.14849703515046078 0.40326853590912515 0.05352822330003983 0.12472310145880992 1.3856046977473313e-07 6.858360652894364 -0.8241236142294525 down VLFSSNGGVVK(ub)GFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLFSSNGGVVKGFK 14 1 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 P26599 PTBP1 Polypyrimidine tract-binding protein 1 1 47379400.0 18467000.0 25649100.0 3263300.0 True False 15356128.726813164 25510923.207352266 3945640.942205573 1.0 1.6612861002400905 0.25694242425280883 23.872311223332726 -6.778602836262942 1.5409801713694227 1.3750890801634015 0.2462155743212711 0.7626127272726497 0.27949353282624506 0.25270054551033155 1.1851011121996593 0.14286079764881113 0.3375342881694415 1.664934542510534e-07 6.778602836262942 -1.1288735058421304 VLGATLLPDLIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLGATLLPDLIQK 13 0 E9PLK3;P55786;P55786-2;H0YDG0 E9PLK3 NPEPPS Puromycin-sensitive aminopeptidase 0 5639400.0 2867500.0 1122400.0 1649500.0 False True 2776472.78209014 1570580.1732386765 1217446.4660607097 1.0 0.565674615422067 0.43848672816601897 21.404821822507177 -13.999999999999998 0.17217447495988933 3.2030627697207876 0.32885073116349534 0.9995096980558572 0.005323030120016063 12.11343224159647 0.13143847384831583 8.915095973105915 0.10167726616780415 1.0000000000000041e-14 13.999999999999998 -2.8742120385572925 VLGATLLPDLIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLGATLLPDLIQK 13 0 E9PLK3;P55786;P55786-2;H0YDG0 E9PLK3 NPEPPS Puromycin-sensitive aminopeptidase 0 11321900.0 1385800.0 4524800.0 5411300.0 False True 1898167.7098368583 4324879.374487344 4133262.3892217777 1.0 2.278449555365713 2.1775011595666744 20.856176034528758 -10.217077216439506 5.507033169515876 0.9999400762366413 2.2279753574662773 0.994957044411188 0.04121201001033644 3.032303806801078e-05 4.310883299798753e-06 0.03990528044235185 0.013301119036102302 6.066284630224256e-11 10.217077216439506 1.228035281229636 VLGATLLPDLIQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLGATLLPDLIQK 13 0 E9PLK3;P55786;P55786-2;H0YDG0 E9PLK3 NPEPPS Puromycin-sensitive aminopeptidase 0 5382440.0 2867500.0 1644400.0 870540.0 False True 2384453.30178896 1635541.2908121573 1052565.8890778176 1.0 0.6859187762599821 0.44142860264368333 21.185227097941453 -7.472460756393708 0.1741505520598193 1.242860227553911 1.8482655171681813e-12 0.9999753230127066 0.0011357013779294382 0.12790861090561695 0.015032044991290103 0.03351962661670667 0.06390281815289993 3.36929659917261e-08 7.472460756393708 -1.2428602275520626 down VLGCPEALTGSYK(ub)SMFQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLGCPEALTGSYKSMFQK 18 1 Q14181;A0A3B3ITS5 Q14181 POLA2 DNA polymerase alpha subunit B 1 25343900.0 2572400.0 3171500.0 19600000.0 True False 3330022.5095847645 2995003.2370274425 16033001.112983027 1.0 0.8993942919025202 4.814682503447178 21.667100498679737 -6.9010057741165225 0.9549207370196808 0.8416784171851985 5.2341078026068555 0.9870591414774575 0.207316305401285 0.11066766479166372 0.17328808210162505 0.1625207934696275 0.4250097652773982 1.2560132643918527e-07 6.9010057741165225 4.392429385421657 up VLGGLLGGHSLAIMLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VLGGLLGGHSLAIMLK 16 0 Q9BZQ6;Q9BZQ6-2 Q9BZQ6 EDEM3 ER degradation-enhancing alpha-mannosidase-like protein 3 0 194635100.0 93175000.0 50477300.0 50982800.0 False True 141353287.0049316 41469231.43405496 40906027.233444944 1.0 0.29337295447970846 0.2893885816183234 27.074730190839457 VLGGLLGGHSLAIMLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VLGGLLGGHSLAIMLK 16 0 Q9BZQ6;Q9BZQ6-2 Q9BZQ6 EDEM3 ER degradation-enhancing alpha-mannosidase-like protein 3 0 183144600.0 93175000.0 43175300.0 46794300.0 False True 120616874.25383316 40772556.600861065 38278217.550064355 1.0 0.33803360311805897 0.3173537515945692 26.845856512931906 VLGIAFSSAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLGIAFSSAR 10 0 Q7KZ85 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 17493900.0 0.0 10617000.0 6876900.0 False True 0.0 10026154.616906935 5625374.762952697 0.0 VLGIQVDTDGSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLGIQVDTDGSGR 13 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 7351400.0 0.0 0.0 7351400.0 False True 0.0 0.0 6590747.647608203 0.0 VLGIQVDTDGSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLGIQVDTDGSGR 13 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 9797200.0 0.0 0.0 9797200.0 False True 0.0 0.0 7483303.139667669 0.0 VLGLSSSFTFGGFQVTSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLGLSSSFTFGGFQVTSK 18 0 P50747 P50747 HLCS Biotin--protein ligase;Biotin--[methylmalonyl-CoA-carboxytransferase] ligase;Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase;Biotin--[methylcrotonoyl-CoA-carboxylase] ligase;Biotin--[acetyl-CoA-carboxylase] ligase 0 18231100.0 7389200.0 4792200.0 6049700.0 False True 9565465.062907705 4525509.857317644 4948716.675163948 1.0 0.47310923489400963 0.5173524384458563 23.189403681924844 -9.9177829252 7.0785244088016475 1.0000000110304523 0.49523083792127975 0.9942710687529484 0.018062212214691637 3.153140813122828e-09 4.4178933590079154e-10 0.017488662296990996 0.005829553925262944 1.2084176914603848e-10 9.9177829252 -0.5047691731091726 VLGLVLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLGLVLLR 8 0 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 167356000.0 63575000.0 62649000.0 41132000.0 False True 83347440.66117585 53302013.40388932 36876055.20600433 1.0 0.6395158985213806 0.4424377630971649 26.31263456345779 -10.804210598049877 0.11004534850372097 1.9511319240709777 5.754126860791719e-18 0.9998655038791052 0.002677326151437829 2.9163816637686373 0.0632113954004362 0.9947873975155727 0.27974099083869636 1.5696014887154665e-11 10.804210598049877 -1.9511319240709777 VLGLVLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLGLVLLR 8 0 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 192263000.0 92695000.0 52695000.0 46873000.0 False True 89752447.9636776 73736388.30079485 34595555.1401417 1.0 0.821552948958402 0.3854552820012482 26.419447952639093 -6.955946553020768 0.48922582497383976 1.0096109624583929 0.1789289833415745 0.9995890803383569 0.0052326326851039814 0.08118213854473755 0.026732914302767277 0.006268453147531295 0.03596808262388064 1.1067599803615322e-07 6.955946553020768 -0.8306819791168184 down VLGLVLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLGLVLLR 8 0 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 227211000.0 58326000.0 81684000.0 87201000.0 False True 88484806.20176713 67106851.99999498 69965684.12844399 1.0 0.7583997172008813 0.7907084518996969 26.398926414331385 -10.250295206566753 8.133087657005122 1.0000001801472092 0.7745540846117865 0.9848302685562844 0.013189985707841946 4.308201060897118e-08 3.977811797321505e-09 0.012771158831818634 0.004257049581932148 5.6195921017151637e-11 10.250295206566753 -0.2254460955354226 VLGLVLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLGLVLLR 8 0 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 341181000.0 63575000.0 90986000.0 186620000.0 False True 87080395.54977503 86965937.66953354 142544199.55954543 1.0 0.9986856067945158 1.636926413340272 26.375844624980683 -6.906434412973832 0.9196828522873346 0.9779417579943247 1.7134120613557604 0.9895046878709605 0.030791386953230866 0.10682337778830953 0.15191040654126037 0.024773010098573724 0.06680700694909011 1.2404109374731082e-07 6.906434412973832 0.7354703033614357 VLGLVLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLGLVLLR 8 0 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 157590000.0 92695000.0 39149000.0 25746000.0 False True 77079999.58476987 38938096.56653189 31129369.56394593 1.0 0.5051647220587896 0.4038579363212236 26.19985322807337 -13.999999999999947 0.2229521012384862 4.025281913085056 0.35117812563568507 0.9995010218606806 0.005817894160925345 13.081622253941637 0.14955951008115415 17.451465262426407 0.054993910532148964 1.0000000000001227e-14 13.999999999999947 -3.674103787449371 VLGLVLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLGLVLLR 8 0 J3QLE5;P14678-2;P63162;P14678;P63162-2;P14678-3 J3QLE5 SNRPN;SNRPB Small nuclear ribonucleoprotein-associated proteins B and B;Small nuclear ribonucleoprotein-associated protein N 0 304166000.0 58326000.0 135480000.0 110360000.0 False True 75504156.7773446 127940418.90350872 90275612.38922496 1.0 1.6944817923176634 1.1956376475462158 26.170052736423834 -10.437744334034763 6.126827463658422 0.9998402007141036 1.4450597199319397 0.514873510174251 0.20365226931085142 0.0004446880471941429 4.080856639707405e-05 0.1972552523982385 0.06572848728818959 3.649687381064887e-11 10.437744334034763 0.4452195192178361 VLGMTLIQK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VLGMTLIQK 9 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 63325300.0 20161100.0 19489900.0 23674300.0 False True 26431397.340370152 16582082.891035186 21224710.535921153 1.0 0.6273630817735256 0.8030112923127021 24.655749361712154 -10.049732406712815 4.835723668939654 1.0000072331586387 0.7151871870389824 0.7780571424633499 0.07170808168989698 18675065.000725683 38811026.14193131 889.7622787147087 0.024547587160578168 8.918002572425257e-11 10.049732406712815 -0.2848200461196563 VLGMTLIQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLGMTLIQK 9 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 38107600.0 20062000.0 3914600.0 14131000.0 False True 19425142.791383572 5477720.194369319 10429667.17908695 1.0 0.28199124470781634 0.5369158564802544 24.21142186792374 -10.279387031940363 5.611382228136198 1.000053409592001 0.4094535505946709 0.8773792342721083 0.10407253695330086 6.954507108003716e-05 8.93086595098108e-06 0.10077686515475497 0.033589266868135174 5.255487023088344e-11 10.279387031940363 -0.5905998589973301 VLGMTLIQK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VLGMTLIQK 9 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 56605400.0 20161100.0 15148200.0 21296100.0 False True 27615203.50324136 14478902.435601374 16266399.786946934 1.0 0.5243090978453916 0.5890378387049601 24.718959423235045 -10.448947107877673 6.046716099276468 1.0002063779664994 0.5566734682753195 0.9842630937897852 0.026425397799797502 7.355375399264929e-05 6.7031332551097554e-06 0.02559797974516789 0.008528760466293441 3.5567463305135375e-11 10.448947107877673 -0.44353290969117987 VLGMTLIQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLGMTLIQK 9 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 36489500.0 20062000.0 9350700.0 7076800.0 False True 16682441.89729385 9300325.923131369 8556526.160573792 1.0 0.5574918816075736 0.5129060969162909 23.991827143358016 -13.999999999999998 0.3243849276490003 5.657362732708914 0.5044812566213582 0.9997030703104944 0.003788615468668696 18.360153946566005 0.18184155308230573 58.167764087256444 0.01459444114369029 1.0000000000000041e-14 13.999999999999998 -5.152881476087556 VLGMTLIQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLGMTLIQK 9 0 Q04760;Q04760-2 Q04760 GLO1 Lactoylglutathione lyase 0 34568600.0 8498700.0 17167000.0 8902900.0 False True 11001734.684422346 16211641.358994195 7282663.551468188 1.0 1.4735532008373822 0.6619559333474846 23.391227680989154 -6.748498505107026 1.6550768396575406 1.2789422636699437 0.6604907579116964 0.6426769587508585 0.1989775113203514 0.30264133704199164 1.6305687801355804 0.09498391537425428 0.23098932856575555 1.7844381307768996e-07 6.748498505107026 -0.6184515057582473 VLGNLQLNLLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLGNLQLNLLSK 12 0 A0A0A0MRE1;B4DJ07;A0A0A0MSB8;Q9UPT5-2;Q9UPT5-5;Q9UPT5-1;Q9UPT5-6;Q9UPT5 A0A0A0MRE1 EXOC7 Exocyst complex component 7 0 6815700.0 3221700.0 1952500.0 1641500.0 False True 3119428.8969694176 2732143.432152989 1211541.9060555652 1.0 0.8758473176956578 0.38838580588664817 21.57285049490929 -6.945303109711165 0.6082401710778071 1.0054061229861198 0.2335186040242128 0.9987791142923664 0.009223295784297512 0.08542867964904198 0.04420520022108592 0.009390951127524725 0.04107863541752644 1.1342189272501916e-07 6.945303109711165 -0.771887518961907 down VLGNLQLNLLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLGNLQLNLLSK 12 0 A0A0A0MRE1;B4DJ07;A0A0A0MSB8;Q9UPT5-2;Q9UPT5-5;Q9UPT5-1;Q9UPT5-6;Q9UPT5 A0A0A0MRE1 EXOC7 Exocyst complex component 7 0 12574700.0 6237900.0 6336800.0 0.0 False True 9463350.351575667 5205948.530355621 0.0 1.0 0.5501168547023962 0.0 23.173919606999153 -7.782185742461381 0.6254234691601237 1.0036786843983343 2.971274826538849e-19 0.9879444165547242 0.044899808052445866 0.11754210054543289 0.15491249761008358 0.043271274063019845 0.07789900559338005 1.6512554253486326e-08 7.782185742461381 -1.0036786843983343 down VLGNLQLNLLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLGNLQLNLLSK 12 0 A0A0A0MRE1;B4DJ07;A0A0A0MSB8;Q9UPT5-2;Q9UPT5-5;Q9UPT5-1;Q9UPT5-6;Q9UPT5 A0A0A0MRE1 EXOC7 Exocyst complex component 7 0 9543410.0 847510.0 3060200.0 5635700.0 False True 1160857.3500965757 2924990.245271871 4304663.730884846 1.0 2.5196810314622473 3.7081763151404665 20.146759269389463 -7.551935318180977 0.1908442189971014 1.424162932984029e-19 5.568345248058395 0.9999504606006256 0.007801109198389674 0.136342739633909 0.019825084273774864 0.17627926674664252 0.334114882865988 2.80585149742733e-08 7.551935318180977 5.568345248058395 VLGNLQLNLLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLGNLQLNLLSK 12 0 A0A0A0MRE1;B4DJ07;A0A0A0MSB8;Q9UPT5-2;Q9UPT5-5;Q9UPT5-1;Q9UPT5-6;Q9UPT5 A0A0A0MRE1 EXOC7 Exocyst complex component 7 0 5301810.0 3221700.0 795410.0 1284700.0 False True 2678986.2955095004 791124.9684534757 1553324.8302183377 1.0 0.295307583237568 0.5798181322621959 21.353255770343566 -10.414433347637516 6.002083898561377 1.00017197044586 0.4375628577504406 0.8389856575846903 0.11615094525824018 0.00026736881231931997 2.608452311617595e-05 0.1124964140527704 0.03748755638595102 3.850939115599464e-11 10.414433347637516 -0.5626091126954194 VLGNLQLNLLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLGNLQLNLLSK 12 0 A0A0A0MRE1;B4DJ07;A0A0A0MSB8;Q9UPT5-2;Q9UPT5-5;Q9UPT5-1;Q9UPT5-6;Q9UPT5 A0A0A0MRE1 EXOC7 Exocyst complex component 7 0 16457500.0 6237900.0 6303400.0 3916200.0 False True 8075084.517391851 5952610.24886608 3203491.7836053106 1.0 0.7371576403993723 0.39671309652620174 22.945045929091602 -6.967581283287161 0.3105750343871006 1.052093425025964 0.07094656014000837 0.9999568967135147 0.0016214183357201894 0.07709560834086154 0.011825334284512603 0.005372578480791156 0.030208187508891246 1.0775035674373142e-07 6.967581283287161 -0.9811468648859556 down VLGNPK(ub)SDEMNVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLGNPKSDEMNVK 13 1 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3 P60660-2 MYL6 Myosin light polypeptide 6 1 6786800.0 2502700.0 2395800.0 1888300.0 True False 3281063.9361812794 2038355.9787552555 1692916.8298526204 1.0 0.6212484786650119 0.5159658155954588 21.645732276412126 -13.999999999999972 0.17961400968188496 2.962852967100595 0.43200021885099116 0.9994986081331227 0.004654197835016522 12.199789591012468 0.13434713908079182 8.356301604962596 0.07886659183418972 1.0000000000000655e-14 13.999999999999972 -2.530852748249604 VLGNPK(ub)SDEMNVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLGNPKSDEMNVK 13 1 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3 P60660-2 MYL6 Myosin light polypeptide 6 1 9432900.0 2074800.0 2460500.0 4897600.0 True False 2008936.609688101 3442990.4813379897 3614771.6351494035 1.0 1.7138372931899197 1.7993457920559361 20.938000611080067 -11.247304368356 0.3720750830036371 3.06449480858219e-13 1.8096635313316234 0.9995147801887451 0.007893955972707194 3.3242825707157633 0.18683310705383907 2.7709805567983765 0.023698003326144194 5.658425882970327e-12 11.247304368356 1.809663531331317 VLGNPK(ub)SDEMNVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLGNPKSDEMNVK 13 1 P60660-2;F8W1R7;G8JLA2;G3V1V0;P60660;J3KND3;B7Z6Z4;F8VPF3 P60660-2 MYL6 Myosin light polypeptide 6 1 9043700.0 2074800.0 4175700.0 2793200.0 True False 1725288.1292246697 4153204.6752884435 3377245.205702391 1.0 2.407252797337022 1.9574963442309763 20.718405886514343 -10.52373613098206 5.771023810086677 0.9978902794534714 2.182374570783998 0.9021044940685817 0.18361230310563498 0.004988984465594823 0.0004117243065910535 0.17795827875788797 0.059260616007242535 2.994083231766891e-11 10.52373613098206 1.1844842913305267 VLGPYTFSICDTSNFSDYIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLGPYTFSICDTSNFSDYIR 20 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 65143000.0 20552000.0 21909000.0 22682000.0 False True 31178886.55245889 17999167.77420169 18198892.758126236 1.0 0.5772870607139178 0.5836928373791141 24.8940660722367 -9.999959175410693 7.180586914073715 1.0000000276606489 0.5804899490467562 0.9998251577906289 0.0026151473726604498 1.158356205598555e-09 1.6289349165753727e-10 0.002532105744203725 0.0008440351851825635 1.0000940065091016e-10 9.999959175410693 -0.41951007861389267 VLGPYTFSICDTSNFSDYIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLGPYTFSICDTSNFSDYIR 20 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 33825000.0 20552000.0 0.0 13273000.0 False True 26604969.140485983 0.0 10857450.192480795 1.0 0.0 0.4080985824546033 24.66519239432915 -10.720651828848617 6.709406547266142 1.010632263355589 0.20404929122730833 0.8353101457506417 0.16660554862781765 0.026144851542504666 0.0010885472104375663 0.15916960397524532 0.053771709601774 1.9026029734961545e-11 10.720651828848617 -0.8065829721282808 VLGQGK(ub)WNLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLGQGKWNLK 10 1 O95067;H1UBN3 O95067 CCNB2;CCNB2V G2/mitotic-specific cyclin-B2 1 23777300.0 1919800.0 2230500.0 19627000.0 True False 2912476.95617996 1832449.8480239552 15747714.847180303 1.0 0.6291723078308639 5.406983500338212 21.47381520438331 -6.888155427497025 1.0332687649345875 0.7318143320404971 5.803316292257131 0.9796898210757885 0.30927825091831496 0.1206510359391653 0.23071018443382504 0.22860637367466455 0.5662442459030166 1.2937327509940053e-07 6.888155427497025 5.071501960216634 up VLGQGK(ub)WNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLGQGKWNLK 10 1 O95067;H1UBN3 O95067 CCNB2;CCNB2V G2/mitotic-specific cyclin-B2 1 6523600.0 1421800.0 3263100.0 1838700.0 True False 1182289.6964197205 3245521.0326253613 2223163.668811755 1.0 2.745114875358924 1.8803882631677078 20.173152151692037 -10.092768850308614 5.69576769114235 0.9999910710624733 2.312751569263498 0.7544737397037586 0.35302316114631643 4.002813179638211e-05 6.375161522115429e-06 0.3418155237929369 0.11393773532867119 8.076647888591226e-11 10.092768850308614 1.3127604982010248 VLGTAFDPFLGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLGTAFDPFLGGK 13 0 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 16452300.0 3370400.0 7449100.0 5632800.0 False True 4418627.039000033 6337723.316364381 5049971.889632928 1.0 1.434319588511515 1.1428825843549295 22.075166732667853 -10.530687303711613 5.599992792729608 0.9993205613831921 1.288601086433221 0.5666325731148012 0.11897865872483658 0.0010115708460109885 8.477578837046559e-05 0.11546291276759835 0.03840019698294888 2.946542409664668e-11 10.530687303711613 0.28928052505002877 VLGTAFDPFLGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLGTAFDPFLGGK 13 0 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 14424200.0 5602500.0 2132300.0 6689400.0 False True 5424651.704153459 2983738.5097976043 4937245.462301623 1.0 0.5500331952211908 0.9101497628910172 22.37109908000175 -9.903682308469778 6.608794359076188 1.0000000153418744 0.7300914790560962 0.428246912641309 0.14701697311894962 3.330481078375509e-08 5.456321632102633e-09 0.1423485806094945 0.04744952404162201 1.2482963238046308e-10 9.903682308469778 -0.26990853628577827 VLGTAFDPFLGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLGTAFDPFLGGK 13 0 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 17212700.0 3370400.0 6071800.0 7770500.0 False True 4616527.961635263 5803527.799242457 5935267.938470946 1.0 1.2571196031891327 1.2856562307853021 22.138376794190744 -12.614426874970254 0.3323260616096073 1.8189768883800864e-07 1.2908181774250904 0.9996384778507904 0.002442551681797903 7.758121789669608 0.18051527734275744 5.297771863910379 0.009066068097748799 2.429814531496654e-13 12.614426874970254 1.2908179955274015 VLGTAFDPFLGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLGTAFDPFLGGK 13 0 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 11251000.0 5602500.0 3032300.0 2616200.0 False True 4658726.982832668 3015964.3980355766 3163235.324057923 1.0 0.647379511430774 0.6789913501508873 22.151504355436025 -9.920072202985928 5.66372667838017 1.0000002576173164 0.6631854311816171 0.993436743964867 0.012905479117740265 4.19886290148427e-08 7.988854829663117e-09 0.012495685919721434 0.004165225474552632 1.2020645705388222e-10 9.920072202985928 -0.33681482643569927 VLGTAFDPFLGGK(ub)NFDEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLGTAFDPFLGGKNFDEK 18 1 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 12677800.0 2974600.0 5419200.0 4284000.0 True False 3899729.4060673746 4610676.483876148 3840732.7750297245 1.0 1.1823067715166724 0.9848716090542434 21.89494259123025 -6.664038714173611 1.9582217124143648 1.1169587214681291 0.9856835420919603 0.25290110564232593 0.07754839452349124 0.475041606119145 3.505779532064004 0.031945264742331905 0.08602760597833231 2.1675108784809026e-07 6.664038714173611 -0.13127517937616884 VLGTAFDPFLGGK(ub)NFDEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLGTAFDPFLGGKNFDEK 18 1 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 18730500.0 5079300.0 6803500.0 6847700.0 True False 4918060.40176825 9520173.029783808 5054081.943403418 1.0 1.9357576467261166 1.0276575581679035 22.229658023004895 -6.639188009322447 2.047316960794106 1.6123117825312665 1.0314243183747258 0.1514954225346048 0.40046519184196916 0.5354464150914401 4.288368038094475 0.1593426466419441 0.4434666145059152 2.2951548433542244e-07 6.639188009322447 -0.5808874641565407 VLGTAFDPFLGGK(ub)NFDEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLGTAFDPFLGGKNFDEK 18 1 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 72501000.0 15158000.0 15279000.0 42064000.0 True False 22995794.19823726 12552343.074628115 33750031.962693855 1.0 0.5458538620766711 1.4676610719224892 24.454866688677473 -6.77272661325405 1.5638307777390417 0.7404206840935112 1.473412067403038 0.7409369931345131 0.19155025507671605 0.2620469466169911 1.2650767669196374 0.09652250940058618 0.22921124992397326 1.687615038418183e-07 6.77272661325405 0.7329913833095267 VLGTAFDPFLGGK(ub)NFDEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLGTAFDPFLGGKNFDEK 18 1 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 14233600.0 2974600.0 4047600.0 7211400.0 True False 4074390.0055424375 3868763.64837672 5508215.843445001 1.0 0.9495319896018787 1.3519117796656959 21.958152652753142 -6.875459689575783 1.1048754208055334 0.970262298221214 1.3780500663653277 0.9698317519992118 0.031086720685831307 0.13172457379137553 0.2972756758120834 0.021755998410194217 0.052052948379149575 1.3321106806665903e-07 6.875459689575783 0.40778776814411366 VLGTAFDPFLGGK(ub)NFDEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLGTAFDPFLGGKNFDEK 18 1 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 17033800.0 5079300.0 6410600.0 5543900.0 True False 4223663.001142693 6376064.825395533 6703103.857902589 1.0 1.5096054831246049 1.587035674032018 22.01006329843917 -11.693777936177929 0.3148236856304737 8.601114871663353e-18 1.6052326097823821 0.9994556994618046 0.006075346642760884 4.386214420684207 0.16787782073018317 2.9552229591147867 0.026277830023594656 2.024053855060244e-12 11.693777936177929 1.6052326097823821 VLGTAFDPFLGGK(ub)NFDEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLGTAFDPFLGGKNFDEK 18 1 Q92598-2;Q92598;Q92598-3;Q92598-4 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 79234000.0 15158000.0 15443000.0 48633000.0 True False 19622329.808850076 14583583.47451198 39782293.0167196 1.0 0.7432136559000492 2.027399060369323 24.225993010769923 -6.854708044622837 1.2121304966200326 0.862201295918215 2.0836013894630274 0.9468852498124757 0.12787181079837434 0.15235134233983527 0.42838811410282107 0.08243709190797636 0.19143311454869152 1.3973073882141451e-07 6.854708044622837 1.2214000935448124 up VLGVPIIVQASQAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLGVPIIVQASQAEK 15 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;Q5QP23 Q14498-3 RBM39 RNA-binding protein 39 0 27447600.0 7664300.0 9109300.0 10674000.0 False True 10047971.521186782 7750227.947773287 9569556.872237943 1.0 0.7713226427275837 0.952386942186284 23.260400944550845 -9.919116589262568 5.464514547189315 1.0000001713296849 0.8618547925682196 0.4369839570522728 0.07391919071988881 1.5429183125165144e-07 3.044647650535199e-08 0.07157203717469852 0.023857316218338705 1.2047124838212637e-10 9.919116589262568 -0.13814537876146527 VLGVPIIVQASQAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLGVPIIVQASQAEK 15 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;Q5QP23 Q14498-3 RBM39 RNA-binding protein 39 0 22344600.0 7565600.0 3812000.0 10967000.0 False True 7325434.169200069 5334151.479317389 8094413.697052322 1.0 0.7281686458592357 1.1049739182812457 22.80448283809992 -6.713175416507538 1.7840842673541542 0.8334233532508506 1.1041651197265476 0.48002429020439386 0.11449375526967166 0.36875708724341155 2.2899468145351882 0.05103492136697304 0.12914628900128203 1.9356399789087396e-07 6.713175416507538 0.27074176647569703 VLGVPIIVQASQAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLGVPIIVQASQAEK 15 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;Q5QP23 Q14498-3 RBM39 RNA-binding protein 39 0 29532300.0 2894500.0 21851000.0 4786800.0 False True 4391168.116294876 17951518.327357776 3840686.8818710246 1.0 4.088096345194062 0.8746389981332964 22.066173338564763 -6.655245447418616 1.9900118574230752 2.9955491886382353 0.8882013860410279 0.21546651153309593 1.3163603486700304 0.4958396572620337 3.7695973322490604 0.5354012741609562 1.4583765009565435 2.2118443024805228e-07 6.655245447418616 -2.107347802597207 VLGVPIIVQASQAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLGVPIIVQASQAEK 15 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;Q5QP23 Q14498-3 RBM39 RNA-binding protein 39 0 30772300.0 7664300.0 9043000.0 14065000.0 False True 10497998.829919629 8643450.35879796 10743136.677767709 1.0 0.8233426673818874 1.0233509120947346 23.323611006073737 -6.673577534121822 1.9248827951119574 0.8875863889340232 1.0225524673540807 0.29487564969998514 0.0749793809220553 0.45297384710427807 3.23907074931288 0.03132271837018402 0.08329217701323817 2.1204228025181577e-07 6.673577534121822 0.13496607842005748 VLGVPIIVQASQAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLGVPIIVQASQAEK 15 0 Q14498-3;Q14498-2;Q14498;G3XAC6;A0A0U1RQH7;H0Y4X3;Q5QP23 Q14498-3 RBM39 RNA-binding protein 39 0 15036300.0 7565600.0 3798800.0 3671900.0 False True 6291131.612908312 3778335.110397233 4439677.313052635 1.0 0.6005811581885752 0.7057040904919532 22.584888113534195 -10.079663019642473 7.325652813361545 1.0000000628176584 0.6531426243402669 0.9355502196205912 0.042916257401402556 4.404543291218766e-08 5.53633941835093e-09 0.041553494669994105 0.013851162516431887 8.324094086462402e-11 10.079663019642473 -0.3468574384773915 VLGWK(ub)DGESTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLGWKDGESTK 11 1 A0A499FJI4;O75592-2;O75592;H7C3U4 A0A499FJI4 MYCBP2 E3 ubiquitin-protein ligase MYCBP2 1 7245600.0 1778300.0 2535700.0 2931600.0 True False 1478735.2420475376 2522039.680802958 3544584.0058130915 1.0 1.7055383608162367 2.397037620409362 20.49593233969409 -6.971372145633861 0.22299243182832515 0.6929189460661073 3.4292514422825056 0.9999911972321647 0.0016921812624188142 0.07585991543417271 0.007416650554143861 0.018722609535663234 0.06964979095336363 1.0681392016923172e-07 6.971372145633861 2.736332496216398 VLHIPEFYVGSILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLHIPEFYVGSILR 14 0 S4R3W9;A0A0A0MRF4;P49406 S4R3W9 MRPL19 39S ribosomal protein L19, mitochondrial 0 29391800.0 20266000.0 4667400.0 4458400.0 False True 19622666.923047557 6531117.160169463 3290611.290866971 1.0 0.33283534729412445 0.16769439667765162 24.22601779624687 -13.999999999999929 0.19609057644121658 4.654887451539171 0.056216437114384 0.9994871959987635 0.00814776191872776 12.456296412824512 0.14042385563677745 17.433613580503494 0.10830285406053389 1.0000000000001636e-14 13.999999999999929 -4.598671014424787 VLHIPEFYVGSILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLHIPEFYVGSILR 14 0 S4R3W9;A0A0A0MRF4;P49406 S4R3W9 MRPL19 39S ribosomal protein L19, mitochondrial 0 26663700.0 8028400.0 8376300.0 10259000.0 False True 12179669.754659439 6881483.820669387 8231304.153320564 1.0 0.5649975704831254 0.6758232627918016 23.53797168006873 -10.046839723662844 7.265224888320998 1.0000000451222268 0.6204104166374709 0.9399103029595467 0.04524439942449139 3.3039401063318685e-08 4.312835151890086e-09 0.04380770659231282 0.014602567123350929 8.97760051633277e-11 10.046839723662844 -0.37958962848475597 VLHIPEFYVGSILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLHIPEFYVGSILR 14 0 S4R3W9;A0A0A0MRF4;P49406 S4R3W9 MRPL19 39S ribosomal protein L19, mitochondrial 0 12211500.0 1718700.0 3126400.0 7366400.0 False True 2354149.8361210865 2988265.310377749 5626608.03577021 1.0 1.2693607112542546 2.3900806777197863 21.16677471678184 -6.943970562195177 0.6215262274034894 0.987745989002533 2.7312249519530236 0.9986390950570243 0.022205516658187482 0.08600099448681099 0.04670492207312172 0.022331606914451546 0.09490179903913985 1.1377044002847573e-07 6.943970562195177 1.7434789629504905 up VLHIPEFYVGSILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLHIPEFYVGSILR 14 0 S4R3W9;A0A0A0MRF4;P49406 S4R3W9 MRPL19 39S ribosomal protein L19, mitochondrial 0 30465400.0 20266000.0 5029400.0 5170000.0 False True 16852076.936026204 5002305.62394226 6251023.096620849 1.0 0.2968361492136545 0.3709348776623179 24.006423071681148 -10.413963805892148 5.976318555562985 1.0002095124800068 0.3338855134494368 0.9908045492097257 0.03025067921471388 8.447214640215064e-05 8.283273815107219e-06 0.029299061296309582 0.009763364734170662 3.8551048477590365e-11 10.413963805892148 -0.66632399903057 VLHIPEFYVGSILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLHIPEFYVGSILR 14 0 S4R3W9;A0A0A0MRF4;P49406 S4R3W9 MRPL19 39S ribosomal protein L19, mitochondrial 0 20467500.0 8028400.0 6605300.0 5833800.0 False True 10392922.06342339 6237709.248474656 4772108.259842875 1.0 0.6001882060125809 0.4591690605126082 23.30909800216118 -13.999999999999998 0.14522016228656312 2.92045459382643 0.29515810916878893 0.9995829670284375 0.004677806205196761 11.942961630921872 0.11974878486227483 6.482937883771268 0.1471981812403091 1.0000000000000041e-14 13.999999999999998 -2.625296484657641 VLHLLALRPYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLHLLALRPYR 11 1 P55199;U3KQ90 P55199 ELL RNA polymerase II elongation factor ELL 0 13104700.0 5441900.0 2889400.0 4773400.0 False True 5269149.863245453 4043152.4880219437 3523103.3410695335 1.0 0.7673253927022727 0.6686284187217123 22.32913878222713 -13.99999999987701 0.1172659067390391 2.111593539502632 0.5051384536870605 0.9997064552969643 0.002380107712496144 11.975060958226118 0.10502648158514519 3.1139966572768008 0.14507006308223122 1.0000000002831941e-14 13.99999999987701 -1.6064550858155715 VLHLLALRPYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLHLLALRPYR 11 1 P55199;U3KQ90 P55199 ELL RNA polymerase II elongation factor ELL 0 14141500.0 4349600.0 4647800.0 5144100.0 False True 5957764.663520272 4442444.827780732 3929169.526065039 1.0 0.7456563121705816 0.6595039831169507 22.50633970642659 -13.999999999999998 0.1511552781053068 2.2320970443783708 0.5659668298658186 0.9995624280973372 0.003023708233541917 11.962261220569582 0.12250230448235397 4.327521286560642 0.08440487247071528 1.0000000000000041e-14 13.999999999999998 -1.666130214512552 VLHLLALRPYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLHLLALRPYR 11 1 P55199;U3KQ90 P55199 ELL RNA polymerase II elongation factor ELL 0 10936300.0 5441900.0 2748400.0 2746000.0 False True 4525180.967046327 2733593.823685313 3320175.9039305374 1.0 0.6040849733065112 0.7337111881511515 22.109544057661406 -10.906841384589642 11.073909047875354 1.030784468805283 0.6688980807288314 0.8968981028458224 0.05291968060962583 0.0272106650575774 0.00022890772517509059 0.03466491197564666 0.017079753473974696 1.2392491092389572e-11 10.906841384589642 -0.36188638807645157 VLHMSLNPTSVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLHMSLNPTSVAR 13 0 Q9Y6D9;Q9Y6D9-3 Q9Y6D9 MAD1L1 Mitotic spindle assembly checkpoint protein MAD1 0 7008500.0 3123500.0 2048200.0 1836800.0 False True 4094938.7480170242 1742616.543821069 1646745.5558297373 1.0 0.4255537508747675 0.4021416820037112 21.965410441558472 VLHNQLVLFHNAIAAYFAGNQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLHNQLVLFHNAIAAYFAGNQK 22 0 P53367;P53367-2;P53367-3 P53367 ARFIP1 Arfaptin-1 0 39069100.0 18694900.0 8005200.0 12369000.0 False True 18101440.632570896 11201718.10656652 9129187.837953877 1.0 0.618830198874374 0.5043348771659223 24.10960118531877 -13.999999999999998 0.16853239511019596 2.914977024782076 0.4017426311107745 0.9995165552714993 0.0046589429287205225 12.077576693838914 0.12997055840964986 7.560209346518224 0.09460883054708615 1.0000000000000041e-14 13.999999999999998 -2.5132343936713015 VLHNQLVLFHNAIAAYFAGNQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLHNQLVLFHNAIAAYFAGNQK 22 0 P53367;P53367-2;P53367-3 P53367 ARFIP1 Arfaptin-1 0 321963000.0 113640000.0 86423000.0 121900000.0 False True 172400188.19683877 71000140.42401901 97806411.56933206 1.0 0.41183331159101894 0.5673219536028644 27.361186108412788 -10.490465386167836 9.389849543237712 1.0000083844839256 0.48957763259716625 0.9349303499126231 0.0634779722878835 1.1142099595070097e-05 6.04604010602939e-07 0.06146329009870611 0.020487427460165727 3.23247082523699e-11 10.490465386167836 -0.5104307518867593 VLHNQLVLFHNAIAAYFAGNQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLHNQLVLFHNAIAAYFAGNQK 22 0 P53367;P53367-2;P53367-3 P53367 ARFIP1 Arfaptin-1 0 58081200.0 18694900.0 16723800.0 22662500.0 False True 15545637.674495032 16633705.569985623 27401123.970439076 1.0 1.0699918471196412 1.7626246374823697 23.890006460753046 -6.926366628194984 0.7760313215481582 0.9879282515081559 1.8925012281788092 0.9957748128451944 0.022373207506383806 0.09456867202012838 0.08724627512057934 0.019958647427386202 0.0639689244505422 1.1847681533519521e-07 6.926366628194984 0.9045729766706533 VLHNQLVLFHNAIAAYFAGNQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLHNQLVLFHNAIAAYFAGNQK 22 0 P53367;P53367-2;P53367-3 P53367 ARFIP1 Arfaptin-1 0 272066300.0 113640000.0 98064300.0 60362000.0 False True 147109220.17929295 92606935.49955219 49376735.36642251 1.0 0.629511429580588 0.3356467752751555 27.132312430505237 -7.715970194312089 0.2278004178606442 1.1781111436083767 1.8347110699869444e-13 0.9998418891407791 0.0034179396073547724 0.12887519036502654 0.029987538144717347 0.04504468238521627 0.08198861475306597 1.9232237154797282e-08 7.715970194312089 -1.1781111436081932 down VLHTALHSSSSYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLHTALHSSSSYR 13 0 Q96S82;H3BV23;H3BSQ2 Q96S82 UBL7 Ubiquitin-like protein 7 0 4813600.0 919680.0 1711120.0 2182800.0 False True 1205709.3861937895 1455827.5658935178 1956944.7948960986 1.0 1.207444830871979 1.6230650746394417 20.201450783675572 -6.96001084306959 0.43528729594449445 0.9843874844450935 1.8622005370842405 0.9997705844720562 0.00392375845758298 0.07969733702010752 0.021117584902823668 0.005449362733104708 0.03446906878552766 1.0964508206146858e-07 6.96001084306959 0.877813052639147 VLHTALHSSSSYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLHTALHSSSSYR 13 0 Q96S82;H3BV23;H3BSQ2 Q96S82 UBL7 Ubiquitin-like protein 7 0 3186140.0 919680.0 746000.0 1520460.0 False True 1259710.5494174922 713039.2533078941 1161358.6628566424 1.0 0.5660342001879825 0.9219250115779938 20.264660845198463 -9.973682633706808 6.865773848404477 1.0000000230044384 0.7439796058829874 0.408286926464664 0.14529181534177218 5.128392542183653e-08 7.327717621092896e-09 0.14067820786732294 0.04689273176324346 1.062471688467907e-10 9.973682633706808 -0.25602041712145096 VLHYLAIQKPADLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLHYLAIQKPADLAR 15 1 Q15042;Q15042-3;Q15042-4 Q15042 RAB3GAP1 Rab3 GTPase-activating protein catalytic subunit 0 6211400.0 1105900.0 1907100.0 3198400.0 False True 1449845.6095508335 1622568.1138175745 2867460.2492192066 1.0 1.1191316531421929 1.9777693778771068 20.467467848740675 -6.932090557019898 0.7294281997834158 0.9879025020816352 2.163809800903607 0.9969334278914594 0.024120352546455143 0.09156661369786193 0.07246819531095061 0.022254732026812815 0.07681817546335729 1.1692555579912319e-07 6.932090557019898 1.1759072988219719 VLHYLAIQKPADLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLHYLAIQKPADLAR 15 1 Q15042;Q15042-3;Q15042-4 Q15042 RAB3GAP1 Rab3 GTPase-activating protein catalytic subunit 0 5211300.0 1105900.0 1983100.0 2122300.0 False True 1514781.1158237683 1895480.0847652615 1621056.4501405186 1.0 1.2513227587567735 1.0701588719363957 20.530677910263567 -10.404749144763326 3.570558605456511 0.9988010942336145 1.1607408152670704 0.5121137182979641 0.07395984732508948 9045676.834257979 9153436.282723328 74453.67170894056 0.025318423912362272 3.9377746175519637e-11 10.404749144763326 0.16193972103345589 VLIAAHGNSLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLIAAHGNSLR 11 0 P18669;P15259 P18669 PGAM1;PGAM2 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2 0 132720000.0 56205000.0 35713000.0 40802000.0 False True 73685299.2899942 30384759.60818369 36580200.440420866 1.0 0.4123585016409056 0.4964382419952813 26.13487348493059 -10.711072559460248 6.848459237776377 1.005730174476892 0.4543983718184732 0.9825005069648459 0.03432541026231936 0.0030100968511290837 0.00012699182836391491 0.03331221499823078 0.01107847852480834 1.945035089037168e-11 10.711072559460248 -0.5513318026584189 VLIAAHGNSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLIAAHGNSLR 11 0 P18669;P15259 P18669 PGAM1;PGAM2 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2 0 84489000.0 24097000.0 13972000.0 46420000.0 False True 23332053.92503091 19551092.463017438 34261209.42985039 1.0 0.8379499089894863 1.4684180629762111 24.475809977835734 -6.838510857193829 1.2893929273561575 0.9137718384456635 1.4885380080423323 0.9218471519922612 0.07473303543999772 0.1705456793511509 0.5514343001983899 0.04546032543199198 0.10468795920456507 1.4504045143006928e-07 6.838510857193829 0.5747661695966688 VLIAAHGNSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLIAAHGNSLR 11 0 P18669;P15259 P18669 PGAM1;PGAM2 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2 0 158798000.0 40662000.0 89997000.0 28139000.0 False True 61687226.790389396 73936332.20022963 22577314.316238184 1.0 1.1985679377590142 0.3659965845596358 25.87846845417128 -6.843773581258571 1.2647675818640836 1.1056381040256502 0.3365046757840594 0.9307468097264573 0.09343578833235168 0.16443803770866772 0.5093231705990764 0.0578892880905192 0.13353098096815186 1.4329347628413926e-07 6.843773581258571 -0.7691334282415908 down VLIAAHGNSLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLIAAHGNSLR 11 0 P18669;P15259 P18669 PGAM1;PGAM2 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2 0 123206000.0 56205000.0 25505000.0 41496000.0 False True 76985507.38301374 24378104.766243715 31695499.43694621 1.0 0.31665836330673525 0.4117073526482931 26.198083546453482 -10.768248756517862 7.107110362942389 1.014330144457713 0.3641828579775142 0.9835156028698877 0.03880358740900893 0.008539537174356128 0.0002784599393926645 0.03641450989614754 0.012523803984016283 1.7051054537418067e-11 10.768248756517862 -0.6501472864801989 VLIAAHGNSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLIAAHGNSLR 11 0 P18669;P15259 P18669 PGAM1;PGAM2 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2 0 66553000.0 24097000.0 27769000.0 14687000.0 False True 20037723.178102385 27619402.885285094 17757983.794984628 1.0 1.3783703188128738 0.8862276236249684 24.25621525327001 -6.701264776660437 1.825843929017808 1.2346459891385426 0.8876285311871863 0.4238998713462121 0.1596760569581945 0.3928537966647289 2.5469144895853137 0.06973760910331334 0.17910157342185987 1.9894600534873414e-07 6.701264776660437 -0.3470174579513563 VLIAAHGNSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLIAAHGNSLR 11 0 P18669;P15259 P18669 PGAM1;PGAM2 Phosphoglycerate mutase 1;Phosphoglycerate mutase 2 0 124030000.0 40662000.0 50675000.0 32693000.0 False True 52637760.56784939 47854891.70309491 26743209.458507888 1.0 0.9091361635989542 0.5080613075101521 25.64959477626373 -6.942619094012671 0.6347296086094342 1.0043787989152204 0.3910269817604554 0.9984872271729486 0.008312856899467532 0.08659183298123521 0.04931907414391129 0.008262609218639366 0.03414134976552657 1.1412503033692554e-07 6.942619094012671 -0.6133518171547649 VLIEFSLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLIEFSLLR 9 0 Q5T4S7-3;Q5T4S7-4;Q5T4S7;Q5T4S7-2;Q5T4S7-5 Q5T4S7-3 UBR4 E3 ubiquitin-protein ligase UBR4 0 7624400.0 2032700.0 2742400.0 2849300.0 False True 3083754.5102755534 2252997.2935310034 2286134.6061074445 1.0 0.7306020262065813 0.7413477948681342 21.55625648992575 -9.931125843487976 5.45230067823698 1.0000003924839416 0.735974910539944 0.9987591840181812 0.004386941688986927 2.0930209173898878e-08 4.109532050792918e-09 0.004247644353546294 0.0014158793413906697 1.1718557531664388e-10 9.931125843487976 -0.26402548194399755 VLIEILCTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLIEILCTR 9 0 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 0 9899700.0 3007800.0 3891300.0 3000600.0 False True 3943254.927576629 3310733.208168599 2690126.695787627 1.0 0.8395940077359509 0.6822096834203093 21.910955551609096 -6.971358905115977 0.22335728099027544 1.069570978674822 0.4477711299090325 0.9999911277080958 0.0003864034688024822 0.07586419050766584 0.007432440636396776 0.004249498918431332 0.01584029834193339 1.068171766996233e-07 6.971358905115977 -0.6217998487657894 VLIEILCTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLIEILCTR 9 0 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 0 42764000.0 10432000.0 17444000.0 14888000.0 False True 15826106.681357097 14330981.90940592 11945380.2743578 1.0 0.9055279480889378 0.7547895711096949 23.91580305156696 -6.964210375296034 0.371357331379721 1.0114149785422317 0.6436443768667033 0.9998959250173006 0.001030167216182041 0.07822997148320011 0.01581118817031927 0.0019828399335193436 0.012792850142572199 1.0858994788620405e-07 6.964210375296034 -0.36777060167552844 VLIEILCTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLIEILCTR 9 0 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 0 16618700.0 3007800.0 4811600.0 8799300.0 False True 4119864.9427386993 4599007.602166571 6721086.567272041 1.0 1.1163005744332384 1.631385169341053 21.974165613131987 -6.942543016772085 0.6354713764783829 0.9943749953100847 1.781332208392073 0.9984783084714519 0.010702664171444578 0.08662553017167113 0.04946984168025396 0.010631131966095617 0.043859779550665626 1.141450238626451e-07 6.942543016772085 0.7869572130819884 VLIEILCTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLIEILCTR 9 0 P20073-2;P20073 P20073-2 ANXA7 Annexin A7 0 34845800.0 10432000.0 14507000.0 9906800.0 False True 13504429.645462714 13699672.697322097 8103864.052352049 1.0 1.0144577043966445 0.600089323659428 23.68692937365941 -6.898816168271028 0.968736190238472 1.0177919829936113 0.5576273168746096 0.9859676506829986 0.02274612706855083 0.1122814238165045 0.18238156223808094 0.017649030387875537 0.04565229195550922 1.2623617643535206e-07 6.898816168271028 -0.46016466611900164 VLIFSQMTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLIFSQMTK 9 0 A0A2R8YFD8;A0A2R8Y425;F5GWX5;A0A2R8Y212;A0A2R8Y521;A0A0C4DGG9;A0A2R8YFK9;A0A2R8Y5J0;Q14839-2;A0A2U3TZM0;Q14839;A0A2R8YD40;A0A2R8YDJ9;A0A2R8Y4X2;A0A2R8YDW2;A0A2R8Y8C1;A0A2R8YER1;A0A2R8Y445;A0A2R8Y5Z7;A0A2R8Y685;A0A2R8Y8B3;K7EMY3;Q8TDI0;Q12873-3;Q12873;Q12873-2;A0A5F9ZHX5;F2Z2R5 A0A2R8YFD8 CHD4;CHD5;CHD3 Chromodomain-helicase-DNA-binding protein 4;Chromodomain-helicase-DNA-binding protein 5;Chromodomain-helicase-DNA-binding protein 3 0 7187600.0 1799700.0 1581600.0 3806300.0 False True 2359424.128319592 1345631.4450285137 3412460.5886077634 1.0 0.5703219819095803 1.446310795778017 21.170003348996858 -6.773324158316928 1.5616801567924874 0.7545965391716196 1.4518749792501122 0.7431293474294657 0.18126179377168128 0.26108820295034035 1.2570790744820788 0.09146249525180007 0.2170660328401825 1.6852946483408454e-07 6.773324158316928 0.6972784400784926 VLIGENEK(ub)AER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLIGENEKAER 11 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 13384600.0 4207000.0 6068600.0 3109000.0 True False 5515417.740645948 5163188.535217526 2787310.5036338535 1.0 0.936137347705748 0.5053670700394514 22.395038729761747 -6.933411956312752 0.7182429720937181 1.0057945134560968 0.4087268162310849 0.9971671570265302 0.011691936851155642 0.0909049228359548 0.06928475648521125 0.010876875295729078 0.038272505637079984 1.1657033476879965e-07 6.933411956312752 -0.597067697225012 VLIGENEK(ub)AER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLIGENEKAER 11 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 33872400.0 0.0 10634000.0 23238400.0 True False 0.0 8736279.61617878 18645320.05424746 0.0 VLIGENEK(ub)AER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLIGENEKAER 11 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 11497700.0 4207000.0 2811900.0 4478800.0 True False 5762441.589900163 2687660.9602901665 3420999.6837814446 1.0 0.46641010036454555 0.5936719063282887 22.45824879128464 -10.02380741135997 7.333619275592824 1.000000032586311 0.5300410033465132 0.9478701649695795 0.05195441472604226 2.766924333956116e-08 3.6796999935424665e-09 0.05030464949695152 0.01676821524965955 9.466568649257751e-11 10.02380741135997 -0.4699590292397978 VLIGENEK(ub)AER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLIGENEKAER 11 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 37481000.0 0.0 10363000.0 27118000.0 True False 0.0 9786289.940190883 22182802.254177216 0.0 VLIIGGGDGGVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLIIGGGDGGVLR 13 0 P19623;K7ESL0 P19623 SRM Spermidine synthase 0 56356000.0 14240000.0 18336000.0 23780000.0 False True 18668777.900356162 15600340.273168208 21319473.713867158 1.0 0.8356380024677772 1.141985502621488 24.15412415284672 -6.761003302320161 1.6090353758783342 0.9046467513140818 1.143147125044537 0.6949182293065574 0.06914052606085076 0.28123602580529994 1.4353310590691775 0.033902521713694636 0.08138147026585418 1.7337908141785536e-07 6.761003302320161 0.2385003737304553 VLIIGGGDGGVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLIIGGGDGGVLR 13 0 P19623;K7ESL0 P19623 SRM Spermidine synthase 0 45367200.0 12806000.0 7566200.0 24995000.0 False True 12399480.539649999 10587423.117211744 18448059.666073017 1.0 0.8538602148175634 1.4878090745077093 23.563776346229435 -6.846038219461318 1.2540316415950052 0.9222038647817029 1.5112835788530514 0.934345850751526 0.06945093916445899 0.1618664244627402 0.49183558813470163 0.04337703964282747 0.10015693671663578 1.425482140576328e-07 6.846038219461318 0.5890797140713485 VLIIGGGDGGVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLIIGGGDGGVLR 13 0 P19623;K7ESL0 P19623 SRM Spermidine synthase 0 57034600.0 6036200.0 43157000.0 7841400.0 False True 9157356.705330495 35455296.16281992 6291543.85299228 1.0 3.8717827975600647 0.6870480265697169 23.126499790087216 -6.6691168993462195 1.9401079725566723 2.834393875818564 0.699858740036937 0.2752954869810478 1.2201117926867089 0.4631574609769266 3.3600159689091957 0.5063957991492005 1.354717707810062 2.1423138753964184e-07 6.6691168993462195 -2.134535135781627 VLIIGGGDGGVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLIIGGGDGGVLR 13 0 P19623;K7ESL0 P19623 SRM Spermidine synthase 0 66497000.0 14240000.0 26866000.0 25391000.0 False True 19504912.821530405 25678971.28601859 19394168.7440597 1.0 1.3165386341882535 0.994322246990591 24.21733421436961 -6.650203536024833 2.007464818755433 1.2053632207499092 0.9956666484248927 0.1950406033152141 0.13509414480821838 0.5080110141961454 3.924222218565889 0.054568626068089425 0.1496674603507996 2.2376721875403237e-07 6.650203536024833 -0.20969657232501648 VLIIGGGDGGVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLIIGGGDGGVLR 13 0 P19623;K7ESL0 P19623 SRM Spermidine synthase 0 25737100.0 12806000.0 6818800.0 6112300.0 False True 10648756.40199109 6782065.7709741695 7390353.669917916 1.0 0.6368880566848226 0.6940109615556684 23.34418162166371 -10.474203714666261 6.106818411306919 1.0002058350056038 0.6654495091202645 0.9786024131169027 0.023320328259852766 6.539343262397351e-05 5.63037185081805e-06 0.02259351282919107 0.007526603581541654 3.355801666113669e-11 10.474203714666261 -0.3347563258853393 VLIIGSGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLIIGSGGR 9 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 23678000.0 6363700.0 6343300.0 10971000.0 False True 8342872.326158464 5396904.365989741 9835826.161263093 1.0 0.6468880446687579 1.1789496203152459 22.99211273684099 -6.7277528886310245 1.7311783915048498 0.7869718348523149 1.1785197123440474 0.5489207239543836 0.14846806950863414 0.3404696365638601 1.9979177414578086 0.06798806154713286 0.16915446044909613 1.8717468519441977e-07 6.7277528886310245 0.3915478774917325 VLIIGSGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLIIGSGGR 9 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 10209000.0 3517600.0 1484500.0 5206900.0 False True 3405935.7134368885 2077268.591565229 3843056.6863482976 1.0 0.6098965941635706 1.1283409346767486 21.699619773929275 -6.705413660201369 1.8117445601888336 0.7590510182137378 1.1269545677770638 0.4431755023324119 0.1645111996308206 0.3843885207355856 2.456578274171132 0.0723428163427919 0.1848009667564848 1.9705449219356802e-07 6.705413660201369 0.36790354956332605 VLIIGSGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLIIGSGGR 9 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 26748700.0 4605100.0 18034000.0 4109600.0 False True 6986273.377906215 14815691.799714869 3297335.7586983345 1.0 2.1206859506198037 0.4719734800424522 22.736091666856964 -6.723650391049894 1.7459918804551595 1.679130068465378 0.4739659150316083 0.5297733125230706 0.47138978395666487 0.3482713122205266 2.076756731933841 0.21420293720152234 0.5354728115509965 1.8895118022616923e-07 6.723650391049894 -1.2051641534337698 VLIIGSGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLIIGSGGR 9 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 18817000.0 6363700.0 5146600.0 7306700.0 False True 8716531.862526197 4919206.194469706 5581007.94621011 1.0 0.5643536066928387 0.6402785000079882 23.055322798363882 -10.75935558791466 7.003576541148997 1.0082066599772013 0.6023160533508799 0.9733902657243025 0.030996207899560976 0.003984080017841957 0.00013689369978349275 0.030104085995952712 0.010003983082548535 1.740381315367143e-11 10.75935558791466 -0.40589060662632137 VLIIGSGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLIIGSGGR 9 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 9042200.0 3517600.0 3511000.0 2013600.0 False True 2925040.2561021256 3492085.546121069 2434634.4501655246 1.0 1.1938589695769115 0.8323422028419841 21.48002504936355 -6.7610387731127 1.6084800151225025 1.1124585553126691 0.8309496376415185 0.6952199507622863 0.08155037417333517 0.28117842203374244 1.4339839674736454 0.03999775059599203 0.09602563007045768 1.7336492134319178e-07 6.7610387731127 -0.2815089176711506 VLIIGSGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLIIGSGGR 9 0 P22102;P22102-2;F8WD69;C9JBJ1;C9JTV6;C9JZG2;C9JKQ7 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 0 17346900.0 4605100.0 8397700.0 4344100.0 False True 5961392.730092064 7930360.612828413 3553518.374230082 1.0 1.330286557501462 0.5960886214210558 22.507217988949414 -6.784405943616751 1.5186918607353062 1.185944237382901 0.589445141790411 0.7826904802624474 0.13995988115538835 0.24377849009077474 1.1107727514249184 0.07256650421798298 0.17060783637040186 1.6428354146581727e-07 6.784405943616751 -0.59649909559249 VLIPVFALGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLIPVFALGR 10 0 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;C9J979 Q5TA45-4 CPSF3L Integrator complex subunit 11 0 4681100.0 1168600.0 1592300.0 1920200.0 False True 1532045.9167384983 1354735.0467367861 1721516.1238590272 1.0 0.8842653029752653 1.1236713632734214 20.547028106050636 -6.775287985343422 1.5545408938545275 0.9340656875892518 1.1252845994683143 0.7502455523204643 0.04885349773911074 0.2579714065971047 1.2310251110365604 0.024762451220632222 0.05865577347386949 1.677691154133109e-07 6.775287985343422 0.19121891187906248 VLIPVFALGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLIPVFALGR 10 0 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;C9J979 Q5TA45-4 CPSF3L Integrator complex subunit 11 0 4507300.0 1168600.0 1335400.0 2003300.0 False True 1600663.0002275584 1276397.6124227352 1530161.7992585895 1.0 0.797418077534919 0.9559550005473069 20.610238167573527 -10.034216496218232 6.343732984408544 1.0000000921165768 0.8766865390411112 0.44649716574834175 0.06472242779521466 8.431521149005835e-08 1.2880252022527693e-08 0.06266726840178447 0.020889073748080633 9.242373258825187e-11 10.034216496218232 -0.12331355307546565 VLIPVK(ub)QYPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLIPVKQYPK 10 1 Q07666;Q07666-2;Q07666-3;Q5VWX1 Q07666 KHDRBS1;KHDRBS2 KH domain-containing, RNA-binding, signal transduction-associated protein 1;KH domain-containing, RNA-binding, signal transduction-associated protein 2 1 13494800.0 3441400.0 5798900.0 4254500.0 True False 4511708.72656501 4933726.723935155 3814285.1520457477 1.0 1.0935383959707543 0.8454191933063361 22.10524250046858 -6.804547561954595 1.4370619728980916 1.0513150204782182 0.8415881775800653 0.8451940858531203 0.04025463911660655 0.21432111564490444 0.8732404608901696 0.022031130455722425 0.05110601532673642 1.568384125985001e-07 6.804547561954595 -0.2097268428981529 VLIPVK(ub)QYPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLIPVKQYPK 10 1 Q07666;Q07666-2;Q07666-3;Q5VWX1 Q07666 KHDRBS1;KHDRBS2 KH domain-containing, RNA-binding, signal transduction-associated protein 1;KH domain-containing, RNA-binding, signal transduction-associated protein 2 1 30638500.0 9444400.0 8044100.0 13150000.0 True False 9144592.691603199 11256151.079427326 9705620.508456107 1.0 1.2309078664337905 1.0613507715185673 23.12448748179236 -10.153940870122618 5.1323138863375695 0.9999933551179393 1.1461293189763293 0.49757166686866006 0.06922139413568486 5.263439876540466e-06 8.677804087368714e-07 0.06702637350481752 0.02234110889065503 7.01550809164911e-11 10.153940870122618 0.14613596385839 VLIPVK(ub)QYPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLIPVKQYPK 10 1 Q07666;Q07666-2;Q07666-3;Q5VWX1 Q07666 KHDRBS1;KHDRBS2 KH domain-containing, RNA-binding, signal transduction-associated protein 1;KH domain-containing, RNA-binding, signal transduction-associated protein 2 1 23834900.0 5232000.0 6185900.0 12417000.0 True False 7937326.510435225 5081977.814342703 9962774.507435553 1.0 0.6402631676624884 1.2551801282632717 22.920221722833965 -6.748161747863142 1.656899445627648 0.7880028460877121 1.2562147550223584 0.6409324459079614 0.15115119805763688 0.3032559129523017 1.637474564238533 0.07208578444053523 0.1753266617220392 1.785822342488979e-07 6.748161747863142 0.46821190893464626 VLIPVK(ub)QYPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLIPVKQYPK 10 1 Q07666;Q07666-2;Q07666-3;Q5VWX1 Q07666 KHDRBS1;KHDRBS2 KH domain-containing, RNA-binding, signal transduction-associated protein 1;KH domain-containing, RNA-binding, signal transduction-associated protein 2 1 16220700.0 3441400.0 5909900.0 6869400.0 True False 4713778.580338116 5648781.076574161 5246989.199733909 1.0 1.1983552006740583 1.1131174513838846 22.168452561991472 -10.14318712209295 4.354511578311776 0.9999727758727563 1.1557363259410303 0.8165463987334636 0.03479816547424691 9.775971308505839e-06 1.923542971776934e-06 0.03369943537413902 0.011231059607130832 7.191390597206397e-11 10.14318712209295 0.15576355006827391 VLIPVK(ub)QYPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLIPVKQYPK 10 1 Q07666;Q07666-2;Q07666-3;Q5VWX1 Q07666 KHDRBS1;KHDRBS2 KH domain-containing, RNA-binding, signal transduction-associated protein 1;KH domain-containing, RNA-binding, signal transduction-associated protein 2 1 26884700.0 9444400.0 13589000.0 3851300.0 True False 7853437.057860749 13515793.35979468 4656589.023600758 1.0 1.7210035886473811 0.5929364416233315 22.904892757226637 -6.734065869489551 1.7085006766964124 1.431917598482 0.5931036934491379 0.5779949127009517 0.3030072854816671 0.32865476960113205 1.8812079877870982 0.14044520320788936 0.34689988802396327 1.8447356067177607e-07 6.734065869489551 -0.8388139050328621 VLIPVK(ub)QYPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLIPVKQYPK 10 1 Q07666;Q07666-2;Q07666-3;Q5VWX1 Q07666 KHDRBS1;KHDRBS2 KH domain-containing, RNA-binding, signal transduction-associated protein 1;KH domain-containing, RNA-binding, signal transduction-associated protein 2 1 16422200.0 5232000.0 5349200.0 5841000.0 True False 6772927.138138504 5051512.317675288 4777997.933721111 1.0 0.7458388691693004 0.7054553867582745 22.691348044926414 -13.999999999999998 0.25891620888487543 2.8501148568398356 0.6905415491943373 0.9995601285456309 0.0027344212888780633 14.369469278994515 0.1610181323926344 13.900783830861215 0.01775644821562261 1.0000000000000041e-14 13.999999999999998 -2.1595733076454984 VLIPVKQYPK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLIPVKQYPK 10 1 Q07666;Q07666-2;Q07666-3;Q5VWX1 Q07666 KHDRBS1;KHDRBS2 KH domain-containing, RNA-binding, signal transduction-associated protein 1;KH domain-containing, RNA-binding, signal transduction-associated protein 2 1 5028600.0 2031300.0 1478300.0 1519000.0 True False 1966817.493377405 2068592.899232658 1121128.330976792 1.0 1.0517462378680011 0.5700215372050603 20.907431661350778 -6.880311517685963 1.0780302727171602 1.0322075026688935 0.5356732930480691 0.9739371194959122 0.034859159960910734 0.12735588130084355 0.27060520756384754 0.024901586511447672 0.0602678555840335 1.3173114973467486e-07 6.880311517685963 -0.4965342096208244 VLIQEK(ub)TQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLIQEKTQLK 10 1 A0A0A0MSX9;P41252;J3KR24;Q5TCC6 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 1 9678500.0 1603800.0 2386400.0 5688300.0 True False 2433081.8534854804 1960528.2749716965 4564005.011729542 1.0 0.8057798269972573 1.8758123592066724 21.214353425412757 -6.85991283484881 1.186210377691369 0.8946523582499585 1.9275336610974168 0.9535313431153002 0.10033373405283272 0.1468910832740783 0.3928043954427896 0.06597436195442538 0.15398522647655394 1.3806613426766588e-07 6.85991283484881 1.0328813028474584 VLIQEK(ub)TQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLIQEKTQLK 10 1 A0A0A0MSX9;P41252;J3KR24;Q5TCC6 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 1 8763100.0 1603800.0 1488000.0 5671300.0 True False 2076150.7156243403 1405191.4919428772 4639181.592452078 1.0 0.6768253775450536 2.2345109907191794 20.985479747505206 -6.852587912926127 1.222561049652429 0.8270861658187646 2.2999514963607295 0.9439841802887787 0.15886241179838057 0.15463339423594172 0.44346351656310606 0.101608763178124 0.23554753370550904 1.4041454178724617e-07 6.852587912926127 1.472865330541965 up VLISTDVWAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLISTDVWAR 10 0 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 51528800.0 9210800.0 26323000.0 15995000.0 False True 13973456.999678299 21625454.987462282 12833581.23914245 1.0 1.5476095133766934 0.9184256436641204 23.736185648402465 -6.676638607131887 1.9139334674133217 1.3475192847064106 0.9208844756930854 0.3087837588763793 0.23226237316405196 0.4460217335481072 3.155900828763297 0.09748303752606571 0.25820772503401346 2.1055298019802098e-07 6.676638607131887 -0.4266348090133252 VLISTDVWAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLISTDVWAR 10 0 P38919;I3L3H2 P38919 EIF4A3 Eukaryotic initiation factor 4A-III;Eukaryotic initiation factor 4A-III, N-terminally processed 0 39198800.0 9210800.0 17114000.0 12874000.0 False True 11923562.17201189 16161590.85558494 10531064.098395085 1.0 1.3554331014871506 0.8832145919542896 23.507311970494914 -6.705350824961769 1.8121063728836064 1.2195443117330114 0.8844835192564972 0.44290069874269855 0.14989099312448378 0.38447084081866006 2.458076050412544 0.06590389269999943 0.16835692420628684 1.9708300478703496e-07 6.705350824961769 -0.3350607924765142 VLITENDVK(ub)EGLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLITENDVKEGLQR 14 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 98300000.0 30428000.0 34899000.0 32973000.0 True False 39891402.66517119 29692205.235236496 29561270.259349972 1.0 0.7443259261765814 0.7410436405927546 25.249574516704268 VLITENDVK(ub)EGLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLITENDVKEGLQR 14 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 172084000.0 57192000.0 52532000.0 62360000.0 True False 55376471.265318014 73508301.550761 46026045.240100585 1.0 1.3274284162775618 0.8311480343263845 25.722769788515418 -6.728786424522026 1.7277366990816116 1.1973143513596245 0.8315136858390771 0.55356360979516 0.13765706430919145 0.3385334491837668 1.9792107124974745 0.0631546249008704 0.1569248056861197 1.867297756758401e-07 6.728786424522026 -0.36580066552054735 VLITENDVK(ub)EGLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLITENDVKEGLQR 14 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 241191000.0 71203000.0 74646000.0 95342000.0 True False 108020156.63656716 61324838.08814001 76497611.91011687 1.0 0.5677166188016823 0.7081790500220472 26.686725304508798 -10.930915241386478 11.413685225435101 1.0589195553710147 0.6379478344118648 0.8985647909645715 0.057343547420111884 0.029452589561863658 0.00017827037083858625 0.019020493396680545 0.0185075503475457 1.172424158115977e-11 10.930915241386478 -0.4209717209591499 VLITENDVK(ub)EGLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLITENDVKEGLQR 14 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 115939000.0 30428000.0 43021000.0 42490000.0 True False 41678053.88578143 41120189.968577646 32454737.10901882 1.0 0.9866149240381374 0.7787008769162045 25.31278457822716 -6.920005118387708 0.8246968563668807 1.0045866473878213 0.7451698058712435 0.9941821695927102 0.007727692077640561 0.09816872493603901 0.10560131151878686 0.006658372063801037 0.019945721243317185 1.2022502653854775e-07 6.920005118387708 -0.25941684151657785 VLITENDVK(ub)EGLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLITENDVKEGLQR 14 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 149790000.0 57192000.0 52011000.0 40587000.0 True False 47557682.03519243 51730806.41962477 49073554.04691502 1.0 1.0877486918169024 1.0318743880452552 25.503175063949694 -10.463600856555866 5.477379016226047 0.9999310199424497 1.0598115399310788 0.6044089491439764 0.02281058899563434 1.9236920884237494e-05 1.88383989380848e-06 0.02211171414637685 0.007362085941439368 3.4387384400856273e-11 10.463600856555866 0.05988051998862909 VLITENDVK(ub)EGLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLITENDVKEGLQR 14 1 Q96S55-2;Q96S55;Q96S55-3;Q96S55-4 Q96S55-2 WRNIP1 ATPase WRNIP1 1 238117000.0 71203000.0 79863000.0 87051000.0 True False 92173687.12096252 75418553.84478076 71208611.21868798 1.0 0.8182221651370694 0.7725481473388236 26.457851626601247 -13.999999999999998 0.19396736661148775 1.9881676501510899 0.7410577252714261 0.9994877093433191 0.0022235890051638015 12.417961197521835 0.13966447880114014 4.644372135954044 0.03044732180084437 1.0000000000000041e-14 13.999999999999998 -1.2471099248796638 VLITTDLLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLITTDLLAR 10 0 P60842;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 100741000.0 27061000.0 28025000.0 45655000.0 False True 35477233.05909677 23843779.240594417 40931058.55368398 1.0 0.6720867774799759 1.1537274760267358 25.080390159544375 -6.7233984224341095 1.7471790462543226 0.8012287300521042 1.1531195953644726 0.5284739155872606 0.13793257553518348 0.3487506678894652 2.082371158083263 0.06264192820062528 0.1566241266594135 1.8906083757408885e-07 6.7233984224341095 0.35189086531236846 VLITTDLLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLITTDLLAR 10 0 P60842;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 96285000.0 34268000.0 24065000.0 37952000.0 False True 33180181.097354848 33674279.99731709 28011232.664405063 1.0 1.0148913864729217 0.8442157859903345 24.983818424753135 -6.885647479460152 1.0477616108974293 1.0101500743781526 0.8307279675958454 0.9779640449524487 0.011458047226832762 0.12274676154304978 0.24303291260240759 0.008376266293925851 0.020580858333154036 1.301225365221034e-07 6.885647479460152 -0.1794221067823072 VLITTDLLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLITTDLLAR 10 0 P60842;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 176788000.0 25735000.0 102570000.0 48483000.0 False True 39041876.48051429 84265582.11693227 38900313.799146205 1.0 2.158338423077309 0.9963740810091765 25.21851905942978 -6.646948247438494 2.020224158162576 1.7534737843861712 1.001320435862096 0.18156584565684852 0.49476830205318884 0.5159724589695934 4.033123930390687 0.1989023603195803 0.5476901212761229 2.2545078538452163e-07 6.646948247438494 -0.7521533485240752 VLITTDLLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLITTDLLAR 10 0 P60842;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 118801000.0 27061000.0 35711000.0 56029000.0 False True 37066182.99602767 34133169.939515 42796104.15347647 1.0 0.9208709173850732 1.1545862210323319 25.143600221067267 -6.815369714240195 1.391841799091315 0.9571398251451716 1.1591967371232457 0.873380094393303 0.034536585322444274 0.19957345413455135 0.7609023508441645 0.0195052757360917 0.04502022006274111 1.5297846038645112e-07 6.815369714240195 0.20205691197807407 VLITTDLLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLITTDLLAR 10 0 P60842;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 67276000.0 34268000.0 15712000.0 17296000.0 False True 28495360.32980093 15627356.337412175 20912513.632331576 1.0 0.5484175724238455 0.7338918824079903 24.76422370018741 -10.184268352288093 5.382137579761571 1.000014605864693 0.6411547274158447 0.8330823476651859 0.07571956997624867 1.3271199128064658e-05 2.0113165961401947e-06 0.07331814066025398 0.024438386124962692 6.542317967170756e-11 10.184268352288093 -0.35885987844884837 VLITTDLLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLITTDLLAR 10 0 P60842;Q14240-2;Q14240;E7EQG2 P60842;Q14240-2 EIF4A1;EIF4A2 Eukaryotic initiation factor 4A-I;Eukaryotic initiation factor 4A-II;Eukaryotic initiation factor 4A-II, N-terminally processed 0 111821000.0 25735000.0 48886000.0 37200000.0 False True 33314464.812690098 46165451.12575228 30429981.704233103 1.0 1.3857479441833027 0.9134164956671241 24.98964538152223 -6.689584660758598 1.8676156074617931 1.2419367539267774 0.9150473723468598 0.36850189733016303 0.16315886405502159 0.41762112645441557 2.8238091223644597 0.06989221422397658 0.18211806058823987 2.0436915028067991e-07 6.689584660758598 -0.32688938157991754 VLIVHTNHLTSLLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLIVHTNHLTSLLPK 15 0 Q6UWE0;Q6UWE0-2 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 0 7117900.0 1610500.0 2608800.0 2898600.0 False True 2111381.0961041846 2219577.2090227557 2598680.6773345396 1.0 1.0512442368259378 1.2307966013949334 21.009755572375774 -6.947919394254079 0.5812427775815642 0.997863577748651 1.2930770951092043 0.9990276790412933 0.0030856726810350116 0.08433224750779819 0.039505019056559815 0.0032286486392056023 0.01500413518402745 1.1274066852304786e-07 6.947919394254079 0.29521351736055335 VLIVHTNHLTSLLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLIVHTNHLTSLLPK 15 0 Q6UWE0;Q6UWE0-2 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 0 7828900.0 2813300.0 1719400.0 3296200.0 False True 2723993.3314225604 2405965.3865525485 2432826.3361196187 1.0 0.8832493673162088 0.8931102393151291 21.377291740832977 -10.236552238750285 5.346762703464986 1.0000092586194913 0.8881798033156547 0.994201353340883 0.004025684136092442 4.4433888087426763e-07 6.345111981801127e-08 0.0038981745840367915 0.001299283968007524 5.800264003337451e-11 10.236552238750285 -0.11182945530383659 VLIVHTNHLTSLLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLIVHTNHLTSLLPK 15 0 Q6UWE0;Q6UWE0-2 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 0 10018000.0 1610500.0 5189400.0 3218100.0 False True 2205945.372126032 4960115.148949037 2458051.058849926 1.0 2.2485212968662993 1.1142846463513831 21.072965633898665 -6.623331157561094 2.105154335661579 1.8265311523690975 1.1187543502668145 0.09383665006350606 0.5364637647012779 0.5765846869954394 4.860346133995899 0.20909059388870166 0.5944312604005341 2.3805035991823443e-07 6.623331157561094 -0.707776802102283 VLIVHTNHLTSLLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLIVHTNHLTSLLPK 15 0 Q6UWE0;Q6UWE0-2 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 0 4939310.0 2813300.0 909410.0 1216600.0 False True 2339383.600321842 904510.8278262487 1470985.4350771632 1.0 0.3866449383084545 0.6287918898272141 21.157697016267253 -10.278215345925599 5.644076337421625 1.0000415342052071 0.5077184140678458 0.8464070245873831 0.09885607899859739 5.167019663726411e-05 6.607869257294198e-06 0.09572503462357293 0.031905662302740306 5.2696849807801916e-11 10.278215345925599 -0.49232312013736135 VLIVVPFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLIVVPFR 8 0 Q68CQ4 Q68CQ4 DIEXF Digestive organ expansion factor homolog 0 2615850.0 930270.0 929720.0 755860.0 False True 1219592.9787474961 791009.4000201758 677650.8579210946 1.0 0.6485847440943213 0.5556368966776375 20.21796831914711 -13.999999999999998 0.18668439783028604 2.8627261042033028 0.48668408271935887 0.9994915778243363 0.004314971941291224 12.298587076887678 0.13701054113010033 8.324532169939845 0.06564806236343576 1.0000000000000041e-14 13.999999999999998 -2.376042021483944 VLIVVPFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLIVVPFR 8 0 Q68CQ4 Q68CQ4 DIEXF Digestive organ expansion factor homolog 0 2961190.0 930270.0 737220.0 1293700.0 False True 1274215.9586014822 704647.1827394717 988154.7045878478 1.0 0.5530045185690958 0.7755001794769535 20.281178380670003 -10.121635403033816 5.253822477571087 1.0000081515700168 0.6642523490227451 0.7522384457018778 0.09083347320223804 8.673086828903273e-06 1.4499743754563885e-06 0.08795126693710689 0.029316377415729514 7.557264054879757e-11 10.121635403033816 -0.33575580254727166 VLK(ub)DSLHEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLKDSLHEK 9 1 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 13938320.0 4369910.0 5484970.0 4083440.0 True False 5728994.328268633 4666633.856245609 3660924.799922355 1.0 0.8145642304477405 0.6390170054556028 22.449850478820107 -6.971789156808635 0.21112748566190132 1.0905974060986998 0.3580770148315787 0.9999931764114789 0.00038496656011310785 0.07572632701854862 0.006913178249773635 0.005210075339833107 0.018143796089630015 1.0671140627129856e-07 6.971789156808635 -0.7325203912671211 VLK(ub)DSLHEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLKDSLHEK 9 1 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 14685420.0 4035220.0 5961450.0 4688750.0 True False 3907124.1498677502 8341888.073551051 3460625.7155151023 1.0 2.13504556128154 0.885721974212731 21.897675667577488 -6.667555013128511 1.9458864316543132 1.7260308525240913 0.8908153675079183 0.26819738373463253 0.4824202278231235 0.46683927901420863 3.405473262403066 0.1997472909194017 0.5354119409089664 2.1500323123161478e-07 6.667555013128511 -0.8352154850161729 VLK(ub)DSLHEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLKDSLHEK 9 1 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 11318480.0 5132470.0 2891000.0 3295010.0 True False 7786332.2238175655 2375078.4625139004 2643749.82924581 1.0 0.30503173949459633 0.3395372497925094 22.892512471603602 -9.9735534204958 5.463717203251716 1.0000016704503503 0.32228449464225584 0.9980595615954575 0.014086815595266948 2.8664305486591436e-07 5.3864306963337384e-08 0.013639534280773333 0.004546500182802831 1.0627878467639347e-10 9.9735534204958 -0.6777171758080944 VLK(ub)DSLHEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLKDSLHEK 9 1 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 11771200.0 4369910.0 3479010.0 3922280.0 True False 5985583.819377378 3325295.8346524057 2995918.2458922644 1.0 0.5555507925371103 0.5005223109888554 22.513060540342998 -13.999999999999998 0.2946139641838537 4.931168563023582 0.48621197218156564 0.9996377911963479 0.004255827148254792 16.24602904653034 0.1722355538799529 38.81165730641636 0.02035916102886597 1.0000000000000041e-14 13.999999999999998 -4.4449565908420166 VLK(ub)DSLHEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLKDSLHEK 9 1 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 11568150.0 4035220.0 5374340.0 2158590.0 True False 3355464.22055618 5345387.36369703 2609941.1888075084 1.0 1.5930395952220922 0.7778182144868472 21.678080943011764 -6.7116007837316 1.7892675990304954 1.3639819985372774 0.7796211926641088 0.47282181229217424 0.2498412044196492 0.3718596477691887 2.3216034977316142 0.11107226197121696 0.28165376376305024 1.942670817267669e-07 6.7116007837316 -0.5843608058731686 VLK(ub)DSLHEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLKDSLHEK 9 1 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 9589270.0 5132470.0 2214300.0 2242500.0 True False 6644083.591108896 2091072.2584738657 1834388.009993085 1.0 0.31472696419294544 0.2760934574104186 22.66363879369605 -13.651342361742303 0.4124691065996666 9.999999983697865 0.2744331879242568 0.999848960594754 0.004086616373030391 21.24209637487041 0.21278452352360905 170.0259327529294 0.009561960196065315 2.231812153615165e-14 13.651342361742303 -9.725566795773608 VLK(ub)DSLHEKFPDAGEDELLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLKDSLHEKFPDAGEDELLK 20 2 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 33279000.0 9565100.0 7447900.0 16266000.0 True False 14510956.002477827 6118764.054291698 13051017.970358951 1.0 0.4216651234589151 0.8993906375383136 23.79063923355419 -10.110902746589195 7.467774719975409 1.0000000778441756 0.6605278804986219 0.40236827486831495 0.1950306244338846 2.5269966726451054e-07 3.014446174041568e-08 0.18883763231637152 0.06294586336940572 7.746352457471749e-11 10.110902746589195 -0.3394721973455537 VLK(ub)DSLHEKFPDAGEDELLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLKDSLHEKFPDAGEDELLK 20 2 P46940;H0YLE8;A0A0J9YXZ5 P46940 IQGAP1 Ras GTPase-activating-like protein IQGAP1 1 29497200.0 9565100.0 8366100.0 11566000.0 True False 12382210.506308986 7900519.180607043 9461106.677181726 1.0 0.6380540192384526 0.7640886635194177 23.56176555564664 -10.398972747798734 5.089591420550406 1.0002609662872972 0.7010713413789135 0.8823607556671393 0.05145342806700043 0.0001524959347965145 1.8008223903473583e-05 0.04986258979177309 0.016606522500720356 3.990499421648425e-11 10.398972747798734 -0.29918962490838374 VLK(ub)FNCEENQHSDSCYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLKFNCEENQHSDSCYK 17 1 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 53927000.0 2212000.0 7240400.0 44474600.0 True False 3355765.7188613806 5948294.05049659 35684175.81609036 1.0 1.7725593944367668 10.633691027810514 21.67821056757059 -6.924057087204648 0.7940653150791998 0.8315629153167032 12.205017502486022 0.9952355023188387 0.3016867218922159 0.09584320686883678 0.09367520791828589 0.26568376557346685 0.8295158558249345 1.1910854317645326e-07 6.924057087204648 11.37345458716932 up VLK(ub)FNCEENQHSDSCYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLKFNCEENQHSDSCYK 17 1 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 4775200.0 1296000.0 1434500.0 2044700.0 True False 1775166.2230831056 1371119.046742859 1561783.9719183529 1.0 0.7723891030111546 0.8797959039609536 20.759522691400477 -10.074045813949132 4.474452566735716 1.0000122040017407 0.8260925034759412 0.7775563148352649 0.04384864290954236 39931816030.03045 35475363132.05165 6091884.574973762 0.016048019687721553 8.432457986375007e-11 10.074045813949132 -0.17391970052579953 VLK(ub)FNCEENQHSDSCYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLKFNCEENQHSDSCYK 17 1 Q96BR5 Q96BR5 COA7 Cytochrome c oxidase assembly factor 7 1 34063100.0 2212000.0 4377600.0 27473500.0 True False 2863477.6050386834 4133982.7117803264 22473604.90191527 1.0 1.4436930480985828 7.8483606305737705 21.44933688966304 -6.9209008342296325 0.8180169072407779 0.863221095501972 8.90288189273031 0.9944275164489692 0.23357813691616017 0.09764471873766228 0.10288871324896459 0.20221713216291268 0.611053355856771 1.1997732252431193e-07 6.9209008342296325 8.039660797228338 up VLK(ub)NSIHEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLKNSIHEK 9 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 1 4790400.0 1348600.0 2332400.0 1109400.0 True False 1768027.6598609772 1984415.0116239905 994609.9301162418 1.0 1.1223891213217942 0.5625533766787617 20.753709414433676 -6.849439991108573 1.237905569072875 1.0652793595941685 0.5404291238558159 0.9394645729015737 0.059126580643761126 0.15808145618644823 0.4664626407875174 0.037381247031663956 0.08646605998544409 1.4143601416002096e-07 6.849439991108573 -0.5248502357383527 VLK(ub)NSIHEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLKNSIHEK 9 1 Q13576;F5H7S7;E7EWC2;Q13576-3;Q13576-2 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 1 3857900.0 1348600.0 1387900.0 1121400.0 True False 1847213.8645446557 1326577.988828453 856548.4159579589 1.0 0.7181507319161763 0.4636974810543125 20.816919475956567 -6.972340557974925 0.1943149515916133 1.1630258985710318 0.011839526234929605 0.9999953463356669 0.0004724850996486674 0.07555029048266025 0.006230933262455721 0.00866111051686349 0.027414928690293165 1.0657600630980441e-07 6.972340557974925 -1.1511863723361022 down VLK(ub)QVHPDTGISSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLKQVHPDTGISSK 14 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 279595000.0 114560000.0 107610000.0 57425000.0 True False 150189269.40061805 91555007.46049462 51483211.859496266 1.0 0.6095975286774906 0.3427888827541257 27.162206499144578 -8.17703027281435 0.19638400458513305 1.278501479269718 8.630352228826382e-17 0.9998095850546184 0.0037241242568161843 0.08671869630022057 0.0397816989673021 0.10181171044699795 0.11364761768184603 6.6522678446625145e-09 8.17703027281435 -1.278501479269718 down VLK(ub)QVHPDTGISSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLKQVHPDTGISSK 14 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 484220000.0 153590000.0 192790000.0 137840000.0 True False 148714369.52091557 269772052.3865687 101735568.88863806 1.0 1.8140281484273602 0.6841004619552229 27.14796881358388 -6.713382381648659 1.7830738706431493 1.498702204824851 0.6864715637929959 0.48120107811031365 0.34285074098344914 0.3683089709674369 2.284638408355758 0.1528947897826014 0.38685059468362576 1.934717760052815e-07 6.713382381648659 -0.8122306410318552 VLK(ub)QVHPDTGISSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLKQVHPDTGISSK 14 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 368860000.0 172320000.0 92380000.0 104160000.0 True False 261422038.2794722 75894067.23176557 83572730.34505013 1.0 0.29031243016562863 0.31968509960016084 27.961805526767453 -9.97145154741439 5.043061341104231 1.0000042963847653 0.30499876487466915 0.9986621862511353 0.011991342116107116 16481546.407809343 2.803881215520302 864.6816595681149 0.0041049553523108085 1.0679439323407669e-10 9.97145154741439 -0.6950055315100961 VLK(ub)QVHPDTGISSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLKQVHPDTGISSK 14 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 312335000.0 114560000.0 144960000.0 52815000.0 True False 156915927.86759284 138555187.88138378 40341184.7590687 1.0 0.8829899536922597 0.2570878897208509 27.22541656066747 -6.938311976080956 0.6750899082503542 1.0072730383408932 0.0963689852712066 0.9979342610925891 0.01482363729700798 0.08854540054267178 0.05818143509097651 0.014251363618450294 0.054283072533675765 1.1526249705101844e-07 6.938311976080956 -0.9109040530696866 down VLK(ub)QVHPDTGISSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLKQVHPDTGISSK 14 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 446998000.0 153590000.0 253480000.0 39928000.0 True False 127716890.19067724 252114452.92815924 48276760.193786755 1.0 1.9740102703077127 0.37799824378522756 26.928374089018156 -6.7415469084506325 1.6810913020135798 1.5784963242656411 0.37675530238007693 0.6118316122377367 0.40922615522721145 0.31503004562650605 1.7486946946346167 0.19253277394287557 0.47164754618852334 1.8132308169652823e-07 6.7415469084506325 -1.2017410218855642 VLK(ub)QVHPDTGISSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLKQVHPDTGISSK 14 1 P57053;O60814;P58876;Q99880;Q99879;P62807;Q16778;Q93079;Q5QNW6;Q5QNW6-2;U3KQK0;Q99877 P57053;P58876;P62807;Q16778;Q93079;U3KQK0 H2BFS;HIST1H2BK;HIST1H2BD;HIST1H2BL;HIST1H2BM;HIST1H2BC;HIST2H2BE;HIST1H2BH;HIST2H2BF;HIST1H2BN Histone H2B type F-S;Histone H2B type 1-K;Histone H2B type 1-D;Histone H2B type 1-L;Histone H2B type 1-M;Histone H2B type 1-C/E/F/G/I;Histone H2B type 2-E;Histone H2B type 1-H;Histone H2B type 2-F;Histone H2B;Histone H2B type 1-N 1 337238000.0 172320000.0 113260000.0 51658000.0 True False 223071636.93502054 106956981.43645845 42256774.05584067 1.0 0.4794736924247093 0.18943140704234768 27.732931848859902 -8.75467265907304 0.2601584049298796 1.2596641002462579 4.681951855730349e-22 0.9991408418793318 0.00982936723697318 0.2985258454310125 0.07900965714603451 0.1792633334514053 0.10925718214171433 1.7592491137916928e-09 8.75467265907304 -1.2596641002462579 VLK(ub)VDGAYVAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLKVDGAYVAVK 12 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 11581800.0 2005400.0 2555400.0 7021000.0 True False 1941739.6747004604 3575784.546234955 5181989.474514854 1.0 1.8415365318147336 2.6687354345346246 20.88891836369945 -6.97133658134757 0.2239748962129369 0.6371712982113801 3.8965673910177854 0.9999910141381702 0.002042186207607655 0.07587132958232976 0.0074592012184183385 0.022231088191377812 0.0831498256409981 1.0682266749745988e-07 6.97133658134757 3.2593960928064054 VLK(ub)VDGAYVAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLKVDGAYVAVK 12 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 23629100.0 5089800.0 5935300.0 12604000.0 True False 7721598.714222714 4876099.342289438 10112813.87547055 1.0 0.6314883125573413 1.3096787659844797 22.880468149757277 -6.75917349406208 1.6159009199603307 0.7857250038849671 1.312028476328787 0.6874662137057961 0.15497747038703366 0.2843055718542245 1.4629865839028118 0.07568387000762905 0.1820058269190371 1.7411111869169787e-07 6.75917349406208 0.5263034724438199 VLK(ub)VDGAYVAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLKVDGAYVAVK 12 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 12136200.0 2971000.0 4760600.0 4404600.0 True False 4069458.9882560987 4550260.950801019 3364324.1955844765 1.0 1.1181488654714173 0.826725175334966 21.956405578351266 -6.79663292084251 1.469486736848022 1.0654688922615738 0.8230227851146833 0.8221734441855633 0.050468707865618974 0.22559914927788904 0.9620579548175159 0.02702249350872648 0.06298134500619484 1.597228603978819e-07 6.79663292084251 -0.24244610714689052 VLK(ub)VDGAYVAVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLKVDGAYVAVK 12 1 O95071;E7EMW7;O95071-2 O95071 UBR5 E3 ubiquitin-protein ligase UBR5 1 19673500.0 5089800.0 4563700.0 10020000.0 True False 6588846.434957451 4309726.083185279 8196462.813882145 1.0 0.6540941765344255 1.2439905672099756 22.651594471849727 -6.747762693822479 1.6579199998398193 0.7960596637746494 1.2449802772890777 0.6393659806392362 0.14533938247504766 0.303966511420656 1.643125936260534 0.06926844727898158 0.1685755054999949 1.7874640099709354e-07 6.747762693822479 0.44892061351442825 VLLAAAVCTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLLAAAVCTK 10 0 P48444;Q6P1Q5;E9PK34 P48444 ARCN1 Coatomer subunit delta 0 16227900.0 8297600.0 7930300.0 0.0 False True 11365446.954208625 7579913.124004806 0.0 1.0 0.6669260922640586 0.0 23.438151084481785 -7.49725348979779 0.7165458497042281 0.9930056400944945 4.739937378151209e-17 0.9870942114081804 0.04723217435080145 0.11887147299959047 0.14226690079522988 0.04168482226060249 0.07548125050178463 3.182339505788604e-08 7.49725348979779 -0.9930056400944945 down VLLALFCHEPCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLLALFCHEPCR 12 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 6131150.0 2533700.0 3075300.0 522150.0 False True 3321705.2363856994 2616477.2274255133 468122.92681647313 1.0 0.7876909723249451 0.1409284971130765 21.663492625504578 -7.1190616911087305 0.6273685097740483 1.0017133776962035 1.858456460724939e-18 0.9983586791738712 0.014801842279078468 0.07875468172296475 0.050465602529130536 0.01463416039923917 0.04916759214899931 7.602182810026271e-08 7.1190616911087305 -1.0017133776962035 down VLLALFCHEPCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLLALFCHEPCR 12 0 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 14491200.0 2533700.0 4211600.0 7745900.0 False True 3470477.3606679444 4025517.586101239 5916477.9518180415 1.0 1.1599319539507007 1.7048023476169079 21.72670268702747 -6.948561910697663 0.5744132735060601 0.9933412967699257 1.8980858405178116 0.9990835543837221 0.009133330769675475 0.084068368410325 0.038392017840351206 0.009628199409531003 0.04544881296990456 1.1257399779878193e-07 6.948561910697663 0.9047445437478859 VLLALFCHEPCRPLHQLATDSTFSLDQPGGTLDLTLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLLALFCHEPCRPLHQLATDSTFSLDQPGGTLDLTLIR 38 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 318255100.0 100186100.0 102176000.0 115893000.0 False True 151989638.28499925 83941894.49526834 92986697.75229365 1.0 0.5522869548374539 0.6117962961260041 27.17939773208096 -10.304856653329468 5.653339197861123 1.0000491192697565 0.5820416254819504 0.9850234398101058 0.024294586847697076 1.5042474839043332e-05 1.8496628168504023e-06 0.023525887225962782 0.0078410441886744 4.9561375000347836e-11 10.304856653329468 -0.4180074937878061 VLLALFCHEPCRPLHQLATDSTFSLDQPGGTLDLTLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLLALFCHEPCRPLHQLATDSTFSLDQPGGTLDLTLIR 38 1 Q13263;Q13263-2;M0R0K9 Q13263;M0R0K9 TRIM28 Transcription intermediary factor 1-beta 0 191055100.0 100186100.0 14818000.0 76051000.0 False True 129692881.41327584 13993365.273931129 62210498.349156685 1.0 0.107896170718424 0.47967550470961 26.95052405417341 -10.638674140857402 6.517007365652626 1.0031201332150608 0.2937858383747925 0.8279144606804065 0.15177827753169523 0.006895946551284464 0.0003823351072128753 0.14728425788111027 0.048986228433025254 2.2978721372036668e-11 10.638674140857402 -0.7093342948402683 VLLATLSIPITPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLLATLSIPITPER 14 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 17928100.0 4896600.0 10672000.0 2359500.0 False True 6419490.0187418545 9079779.199130194 2115361.5739221857 1.0 1.4144081808089992 0.329521748261363 22.614027259715964 -6.803165299536688 1.4429060432780378 1.2277335034646197 0.3133387787067894 0.8412841749834645 0.1780796746998148 0.21626047974999643 0.8885361470039934 0.0970769005203169 0.2253489624469261 1.573383895008253e-07 6.803165299536688 -0.9143947247578303 down VLLATLSIPITPER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLLATLSIPITPER 14 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 27973500.0 13044000.0 10342000.0 4587500.0 False True 12629925.359924622 14471614.53281751 3385896.1279499936 1.0 1.1458194819374514 0.26808520489706217 23.590342777352458 -6.8642128967938145 1.1641904343614242 1.0801960775779347 0.22201489702273206 0.9585628104556884 0.07817565579369469 0.14252892978714757 0.3646964378722331 0.05227468912492585 0.12266995469188666 1.367058511479012e-07 6.8642128967938145 -0.8581811805552026 down VLLATLSIPITPER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLLATLSIPITPER 14 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 112909000.0 34225000.0 48211000.0 30473000.0 False True 51921827.182654 39607370.37573776 24449998.19320965 1.0 0.7628269751833725 0.47090018822330443 25.629837818368507 -6.968334803631527 0.29526211511986106 1.0535669058652535 0.17107410197908748 0.9999663243326847 0.0012557097507722816 0.07684681764718941 0.010953861727790774 0.004960679271266429 0.026316182909076336 1.0756356714803408e-07 6.968334803631527 -0.882492803886166 down VLLATLSIPITPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLLATLSIPITPER 14 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 39246600.0 4896600.0 15018000.0 19332000.0 False True 6707005.345639451 14354455.102115225 14766179.755037712 1.0 2.1402182289071456 2.201605484724702 22.677237321238856 -10.852142233451502 0.5284541886683757 1.8617684918976015e-19 2.197472822920849 0.9997993678185485 0.00782645874161327 2.5199616725551635 0.25633744246622825 3.1628836417454713 0.011862112062073162 1.4055871124601656e-11 10.852142233451502 2.197472822920849 VLLATLSIPITPER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLLATLSIPITPER 14 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 25457600.0 13044000.0 5304500.0 7109100.0 False True 10846663.947178815 5275923.605639182 8595579.941235455 1.0 0.48640979672016427 0.7924630082663472 23.370748052786734 -10.307574418433873 5.898182541322956 1.0000297118300236 0.639436402493258 0.6491945901220407 0.12494570040470783 4.882099104210276e-05 5.731523053998805e-06 0.12098810292347645 0.04032605140397068 4.9252194013137364e-11 10.307574418433873 -0.3605933093367657 VLLATLSIPITPER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLLATLSIPITPER 14 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 83594000.0 34225000.0 26144000.0 23225000.0 False True 44304937.17560979 24689063.417576972 18998288.308624037 1.0 0.5572530961892096 0.4288074765419765 25.400964140460957 -13.999999999999998 0.17351396616794798 3.254067337252662 0.3196406331336705 0.9995074142935005 0.005430336555038093 12.127650494439132 0.13197060610518202 9.204918063866485 0.10146222310580616 1.0000000000000041e-14 13.999999999999998 -2.9344267041189913 VLLDIFTGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLLDIFTGVR 10 0 P49916-3;P49916 P49916-3 LIG3 DNA ligase 3 0 2061400.0 879960.0 852540.0 328900.0 False True 852026.151465751 1192963.667937368 242751.22321149902 1.0 1.4001491220487752 0.2849105309665567 19.700538186590904 -6.809651655774522 1.4158767336293825 1.2181631088024123 0.26553025203149855 0.8589631812455029 0.17324287998701238 0.2072635401281302 0.8189677839210512 0.09621015296240187 0.22260163939630073 1.5500594110242937e-07 6.809651655774522 -0.9526328567709137 down VLLDLSAFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLLDLSAFLK 10 0 Q3ZCQ8;Q3ZCQ8-2;M0R0C3;M0R2F8;M0R003;Q3ZCQ8-3 Q3ZCQ8 TIMM50 Mitochondrial import inner membrane translocase subunit TIM50 0 32876000.0 0.0 18792000.0 14084000.0 False True 0.0 15438420.777433831 11300291.226763502 0.0 VLLDLSAFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLLDLSAFLK 10 0 Q3ZCQ8;Q3ZCQ8-2;M0R0C3;M0R2F8;M0R003;Q3ZCQ8-3 Q3ZCQ8 TIMM50 Mitochondrial import inner membrane translocase subunit TIM50 0 18756600.0 0.0 7332600.0 11424000.0 False True 0.0 6924534.364126565 9344949.220138688 0.0 VLLEK(ub)YK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLLEKYK 7 1 A0A087WUC6;E9PI68;Q15005;H0YE04 A0A087WUC6 SPCS2 Signal peptidase complex subunit 2 1 39420300.0 1002300.0 13014000.0 25404000.0 True False 1520562.37794519 10691550.021153908 20382888.26503124 1.0 7.031313003812392 13.404835316638328 20.536173570504648 -7.384253324339087 0.3268248658260474 4.061879279529359e-21 17.984059219587074 0.9995839248049485 0.10331333193481879 0.13259813916617738 0.03318943461558339 0.31408754353233403 1.1156715647286184 4.128066412864063e-08 7.384253324339087 17.984059219587074 VLLEK(ub)YK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLLEKYK 7 1 A0A087WUC6;E9PI68;Q15005;H0YE04 A0A087WUC6 SPCS2 Signal peptidase complex subunit 2 1 42663100.0 1002300.0 9926800.0 31734000.0 True False 1297497.108286741 9374364.853641488 25958737.618336942 1.0 7.224960112643115 20.006778783972578 20.307299892597097 -6.95952749587953 0.4420500270106125 0.5526228489780213 27.1791541448819 0.9997522511161175 0.1245335403703963 0.0798704455913899 0.021758943492231543 0.16895946430281147 1.058650491711453 1.097671792713713e-07 6.95952749587953 26.626531295903877 VLLESEQFLTELTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLLESEQFLTELTR 14 0 P37108;H0YLA2 P37108 SRP14 Signal recognition particle 14 kDa protein 0 3783530.0 701630.0 1834900.0 1247000.0 False True 919843.7245945845 1561140.072384179 1117972.402068644 1.0 1.6971796737236446 1.215393845907231 19.81102925201601 -10.674483457335908 5.58683197685298 0.9930716209888654 1.4562867598154379 0.5446124595047046 0.19668824057576806 0.017095419209616186 0.000996063122615889 0.19180785463811653 0.06348085667873228 2.1160042841959958e-11 10.674483457335908 0.4632151388265725 VLLGETGKEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLLGETGKEK 10 1 P62280;M0QZC5;M0R1H6 P62280 RPS11 40S ribosomal protein S11 1 3963200.0 1076000.0 1179000.0 1708200.0 True False 1041842.9689726228 1649780.8484037786 1260771.1750984571 1.0 1.5835216030978763 1.2101355124004176 19.990706414160616 -10.136020278853234 5.323513470729646 0.9999900185646974 1.3968285577493436 0.60095954024497 0.15243423321091168 1.805867982152476e-05 2.93091302826478e-06 0.1475975219357905 0.04919793721804702 7.311049446291737e-11 10.136020278853234 0.3968385391846462 VLLGETGKEK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLLGETGKEK 10 1 P62280;M0QZC5;M0R1H6 P62280 RPS11 40S ribosomal protein S11 1 3198680.0 1076000.0 1608100.0 514580.0 True False 894741.6748822755 1599436.8461171435 622176.2988509008 1.0 1.7875962314235416 0.6953697545526343 19.771111689594893 -6.7132169981841985 1.7834149014486753 1.482606462571619 0.6976551876475942 0.4803954808242348 0.3317295673175257 0.36870749437971434 2.287833551109548 0.14790310216602928 0.37433026163367455 1.9354546592556595e-07 6.7132169981841985 -0.7849512749240249 VLLGQDEPLIHVFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLLGQDEPLIHVFAK 15 0 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 0 10573000.0 4168800.0 3817000.0 2587200.0 False True 5465337.170716626 3247518.478549464 2319501.3621748136 1.0 0.5942027686690085 0.4244022444951326 22.381879071537146 -13.99999999999999 0.11940175389024726 2.934976201613508 0.1511928881185087 0.9996958822984552 0.004211171036284135 11.966094774116819 0.10626730578227421 5.498676564521054 0.24243440785614445 1.0000000000000246e-14 13.99999999999999 -2.7837833134949994 VLLGQDEPLIHVFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLLGQDEPLIHVFAK 15 0 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 0 13829100.0 4047600.0 4800600.0 4980900.0 False True 3919111.1535442285 6717504.614798278 3676252.866202964 1.0 1.7140377885744158 0.938032304309196 21.902095060455913 -6.664799000678503 1.9559277519133844 1.4577864025710472 0.9412355155822241 0.2562180205023754 0.30367514119373107 0.47313936174964605 3.48445589626588 0.12522179966646155 0.3368324144250096 2.1637197005417053e-07 6.664799000678503 -0.5165508869888231 VLLGQDEPLIHVFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLLGQDEPLIHVFAK 15 0 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 0 19323500.0 2777200.0 12617000.0 3929300.0 False True 4213215.440516194 10365397.772929046 3152672.132726632 1.0 2.4602107153720816 0.748281728584089 22.00649025854917 -6.680761629741631 1.8988705823223533 1.9232248654554487 0.7546934693512962 0.32781576374392807 0.6187625148934821 0.43679058207221994 3.045562407338545 0.2613909139670507 0.6888074975485645 2.085635307069787e-07 6.680761629741631 -1.1685313961041524 VLLGQDEPLIHVFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLLGQDEPLIHVFAK 15 0 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 0 18694100.0 4168800.0 7335400.0 7189900.0 False True 5710118.017583983 7011297.773076037 5491793.700638608 1.0 1.227872655431139 0.9617653582162299 22.445089133060037 -6.680009449814375 1.9020148219739854 1.1441772817990534 0.9627818848230588 0.3241169332010191 0.0965777202250878 0.43848975887472846 3.067023330682056 0.04074505975013646 0.10745473892124748 2.0892506703505412e-07 6.680009449814375 -0.1813953969759946 VLLGQDEPLIHVFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLLGQDEPLIHVFAK 15 0 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 0 7419100.0 4047600.0 1720300.0 1651200.0 False True 3365758.739083179 1711032.4024471869 1996458.2857137998 1.0 0.5083645427637711 0.5931673778429015 21.68250033589019 -10.801879646299506 7.21195186514449 1.0167354811176226 0.5507659603033364 0.9739695261260334 0.034620612447543914 0.008970354951011094 0.00024642535044829515 0.032277685029018975 0.011173754620403233 1.5780485252335722e-11 10.801879646299506 -0.4659695208142862 VLLGQDEPLIHVFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLLGQDEPLIHVFAK 15 0 Q9BT73 Q9BT73 PSMG3 Proteasome assembly chaperone 3 0 11400800.0 2777200.0 5096500.0 3527100.0 False True 3595140.1467963057 4812875.294816438 2885203.991102169 1.0 1.338717017500772 0.802528934420881 21.77761658064162 -6.735975061893015 1.7013377599177697 1.2024705276718775 0.8024777047087138 0.5867540798199586 0.14233492087111602 0.3251613792750037 1.8463973578028865 0.06622596682115889 0.1632420604741927 1.8366438042892115e-07 6.735975061893015 -0.39999282296316363 VLLK(ub)PLTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLLKPLTGR 9 1 Q9UJJ7;H3BSG4;H3BMZ6;H3BQN8 Q9UJJ7 RPUSD1 RNA pseudouridylate synthase domain-containing protein 1 1 8357200.0 2401200.0 2355800.0 3600200.0 True False 3147996.453253874 2004323.8228364773 3227685.839556963 1.0 0.6366982468372038 1.02531431896015 21.586002484732493 -11.756206497438935 13.245461991090336 0.9027027674857665 0.8479056546082814 0.0 0.18185625567374372 0.0 0.0 0.0 0.05280254682445007 1.753046768607272e-12 11.756206497438935 -0.05479711287748512 VLLK(ub)PLTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLLKPLTGR 9 1 Q9UJJ7;H3BSG4;H3BMZ6;H3BQN8 Q9UJJ7 RPUSD1 RNA pseudouridylate synthase domain-containing protein 1 1 11692400.0 2107400.0 2885000.0 6700000.0 True False 2040501.7405324406 4036995.5450762454 4945069.004308429 1.0 1.9784327868413616 2.4234573811331726 20.960492510528592 -9.748101258987779 0.20547471070695375 1.4297631671327147e-20 2.8161739694657393 0.999406154884482 0.01448900879027933 1.201147060276366 0.08818042157560281 0.9623554335062902 0.2538002826649273 1.7860710905451184e-10 9.748101258987779 2.8161739694657393 VLLK(ub)PLTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLLKPLTGR 9 1 Q9UJJ7;H3BSG4;H3BMZ6;H3BQN8 Q9UJJ7 RPUSD1 RNA pseudouridylate synthase domain-containing protein 1 1 7867400.0 2401200.0 2022600.0 3443600.0 True False 3288988.529990081 1933234.8441562252 2630292.6031682063 1.0 0.5877900839508416 0.7997269005909664 21.649212546255384 -10.083129659059384 4.83873245889899 1.000011209176825 0.6937584922678857 0.7357225812131423 0.08652284309009045 1.046291745458324e-05 1.982549584534028e-06 0.08377844726342283 0.027925127528055524 8.257913719168327e-11 10.083129659059384 -0.3062527169089393 VLLK(ub)PLTGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLLKPLTGR 9 1 Q9UJJ7;H3BSG4;H3BMZ6;H3BQN8 Q9UJJ7 RPUSD1 RNA pseudouridylate synthase domain-containing protein 1 1 8610700.0 2107400.0 4264700.0 2238600.0 True False 1752396.473649543 4241725.214623325 2706680.9098830624 1.0 2.420528275652999 1.5445596647693118 20.74089778596287 -10.049075203985204 5.518061327554604 0.9999944397969388 1.9825439702117174 0.6265189486501801 0.35761268789524875 2.4462259860423778e-05 4.215226894654025e-06 0.3462589498842522 0.115418998717277 8.931508091543166e-11 10.049075203985204 0.9825495304147785 VLLLHGNVYCTVAPLRR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLLLHGNVYCTVAPLRR 17 1 F5H179 F5H179 ORAOV1 0 2688170.0 946650.0 916650.0 824870.0 False True 1241067.317371641 779889.393073715 739520.3651117578 1.0 0.6284021681639168 0.5958744983132179 20.24314994087968 -13.999999999999998 0.34485531824306 5.427474492770034 0.5910696547890888 0.9997447851643034 0.002928634232838894 20.158397212552693 0.1886875091149198 65.21855878128301 0.00987913580627826 1.0000000000000041e-14 13.999999999999998 -4.836404837980945 VLLLHGNVYCTVAPLRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLLLHGNVYCTVAPLRR 17 1 F5H179 F5H179 ORAOV1 0 9347400.0 3209700.0 1603100.0 4534600.0 False True 3107809.8304009517 2243226.1900560595 3346852.224915973 1.0 0.7218029134577554 1.0769166736576612 21.567466796000502 -6.697712114711906 1.8387914271867005 0.8268690449672164 1.075824943847009 0.40685677468296755 0.1174797525128017 0.40028897015147996 2.629595543614495 0.05099845504935148 0.13153780277324686 2.005801193020286e-07 6.697712114711906 0.24895589887979275 VLLLSSPGLEELYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLLLSSPGLEELYR 14 0 Q8N163;Q8N163-2;E5RHJ4 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 0 5988340.0 999340.0 3393700.0 1595300.0 False True 1310144.4176223262 2887373.1885389867 1430233.659198161 1.0 2.2038587118350232 1.0916610718334203 20.321294418570755 -6.627445339057949 2.0901129111772794 1.7946220678541829 1.0961271659162524 0.1081928394709395 0.5167331247938024 0.5657284706670108 4.7064348812607015 0.20245935749963812 0.5723911242927898 2.35805896605351e-07 6.627445339057949 -0.6984949019379305 VLLLSSPGLEELYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLLLSSPGLEELYR 14 0 Q8N163;Q8N163-2;E5RHJ4 Q8N163 CCAR2 Cell cycle and apoptosis regulator protein 2 0 11876640.0 999340.0 4123200.0 6754100.0 False True 1368823.0041480472 3941023.3904009466 5158920.685055877 1.0 2.8791329327883646 3.768873455094203 20.384504480093646 -9.078961851005788 0.2663131575754421 1.290821996323931e-13 4.29234241474294 0.9989838320077394 0.03679263791620074 0.5271851193161365 0.09354012632002019 0.847674199531842 0.349520455321083 8.33754419479642e-10 9.078961851005788 4.292342414742811 VLLPEYGGTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLLPEYGGTK 10 0 P61604;B8ZZL8;B8ZZ54 P61604 HSPE1 10 kDa heat shock protein, mitochondrial 0 113519900.0 3294900.0 49703000.0 60522000.0 False True 4319645.807856985 42287506.14077657 54259764.00801802 1.0 9.789577206506145 12.561160433414509 22.042481591852454 -8.954120280067665 0.4910253962471012 3.4597872530824936e-16 12.662347753005086 0.9966279899850545 0.2861851084832814 0.44107992449624683 0.1893680066860966 1.6623962364479745 0.5714436561371744 1.1114238701533962e-09 8.954120280067665 12.662347753005086 VLLPEYGGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLLPEYGGTK 10 0 P61604;B8ZZL8;B8ZZ54 P61604 HSPE1 10 kDa heat shock protein, mitochondrial 0 69880000.0 19535000.0 10960000.0 39385000.0 False True 18914872.11791839 15336385.15564495 29068886.9753265 1.0 0.8108109354393426 1.5368270424513752 24.173017686675028 -6.837479640382136 1.2939379709225232 0.8992962645322217 1.559555250545316 0.9200501447681823 0.08695039187248128 0.17176408354843106 0.5596963092668195 0.05271141630257989 0.121374627443847 1.4538525402575067e-07 6.837479640382136 0.6602589860130944 VLLPEYGGTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLLPEYGGTK 10 0 P61604;B8ZZL8;B8ZZ54 P61604 HSPE1 10 kDa heat shock protein, mitochondrial 0 131482200.0 3294900.0 67288300.0 60899000.0 False True 4513113.571324471 64315280.41334792 46515910.45427479 1.0 14.250756023955587 10.306833568255115 22.105691653375345 -9.809819404982633 7.3132963846275665 0.9999999778100862 12.278794796105425 0.91599844173777 1.6100996002620258 5.49395962306185e-07 1.2705896428970647e-07 1.5589722343871881 0.5196574114624638 1.5494608056113012e-10 9.809819404982633 11.278794818295339 VLLSK(ub)LPRPWIVDEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLLSKLPRPWIVDEK 15 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 16558800.0 2791400.0 4018900.0 9748500.0 True False 2702788.534935107 5623667.728286628 7195075.401268774 1.0 2.080690981035869 2.662093355905672 21.366017209744772 -9.155053674924273 0.19414035830782445 3.261313471358578e-11 3.2925560395885163 0.9995810110284539 0.014096666615135318 0.602544331354919 0.06863549566749215 0.7046806407108045 0.3345408141237795 6.997555071185459e-10 9.155053674924273 3.2925560395559033 VLLSK(ub)LPRPWIVDEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLLSKLPRPWIVDEK 15 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 37123400.0 3018300.0 25053000.0 9052100.0 True False 4578981.7672872115 20582096.410017557 7262948.467323621 1.0 4.494906827770858 1.5861492437491203 22.126595389785145 -6.601008603022621 2.1864584351042615 3.3489171289555473 1.5956240736906009 0.023386088972175645 1.5102342521535743 0.6380612269812661 5.766045203692243 0.5729758008847113 1.6800056729735726 2.5060596095253434e-07 6.601008603022621 -1.7532930552649464 VLLSK(ub)LPRPWIVDEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLLSKLPRPWIVDEK 15 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 14941600.0 2791400.0 5616300.0 6533900.0 True False 2321172.7799873427 5586043.8771517305 7900108.280659774 1.0 2.4065609959385235 3.4034985886327918 21.14642248517905 -7.976325253823191 0.19136466080935688 3.630546132780123e-25 4.809694298708474 0.9998660164841154 0.011412641123168964 0.11004598043732229 0.033385448528102796 0.305971632056497 0.40409051905447674 1.0560263288824993e-08 7.976325253823191 4.809694298708474 VLLSK(ub)LPRPWIVDEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLLSKLPRPWIVDEK 15 2 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 29925700.0 3018300.0 22018400.0 4889000.0 True False 3907248.8495878223 20793056.684270836 3999252.165376229 1.0 5.321661733028422 1.023546827788589 21.897721711877594 -6.644910138439881 2.0265895283610607 3.815537015104854 1.0415063809976413 0.17369987971026812 1.8468581015817502 0.5211333091894409 4.0964026000011895 0.7405657118452516 2.0454470016286606 2.265112942435265e-07 6.644910138439881 -2.7740306341072127 VLLSLEHGLWAPNLHFHSPNPEIPALLDGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLLSLEHGLWAPNLHFHSPNPEIPALLDGR 30 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 636721000.0 137050000.0 169469000.0 330202000.0 False True 207914869.69708523 139225932.88265958 264937429.96732217 1.0 0.6696295127207604 1.274259173253525 27.631417699936385 -6.7583576461936445 1.6188842981667861 0.8077105977529838 1.276273589770064 0.6841550576220046 0.13892271941332993 0.2856761167359361 1.475265946316254 0.06772357454986051 0.16300041584560965 1.74438504135274e-07 6.7583576461936445 0.4685629920170803 VLLSLEHGLWAPNLHFHSPNPEIPALLDGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLLSLEHGLWAPNLHFHSPNPEIPALLDGR 30 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 347811000.0 137050000.0 94325000.0 116436000.0 False True 177413926.65938148 89075730.83166115 95245842.73424968 1.0 0.5020785713326689 0.5368566297341076 27.402544022028835 -10.087729198468976 7.428955910452657 1.0000000802607143 0.5194676005333883 0.9960868736828037 0.01419808288803981 1.8885354138156434e-08 2.316258920575866e-09 0.013747236896683892 0.00458241154778755 8.170917048237008e-11 10.087729198468976 -0.48053247972732605 VLLSLLSIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLLSLLSIK 9 0 Q9Y4B6;Q9Y4B6-2;Q9Y4B6-3 Q9Y4B6 VPRBP Protein VPRBP 0 2813500.0 689900.0 1284600.0 839000.0 False True 904465.5810011034 1092942.6873315803 752188.3282562881 1.0 1.2083850511169945 0.8316384216895595 19.78670607726804 -6.756522831562957 1.6252798905188208 1.1215591899215864 0.8304792443954455 0.6767608113874561 0.0876094817975729 0.28877870837167724 1.50255759581082 0.042545563453179655 0.10260917652146466 1.751770338389323e-07 6.756522831562957 -0.2910799455261409 VLLSLLSIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLLSLLSIK 9 0 Q9Y4B6;Q9Y4B6-2;Q9Y4B6-3 Q9Y4B6 VPRBP Protein VPRBP 0 4801100.0 689900.0 1662600.0 2448600.0 False True 944974.6738464761 1589140.834517031 1870291.1104999625 1.0 1.6816755818952331 1.9791970750782433 19.84991613879093 -10.39984001135815 0.18026926845267147 1.564660901095127e-16 2.2862821469800965 0.9995122455111726 0.009052304339798974 2.112083063710146 0.09128277294779455 1.1661036356333763 0.21005703721178406 3.9825385526031595e-11 10.39984001135815 2.2862821469800965 VLLVGADNFTLLGKPLLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLLVGADNFTLLGKPLLGK 19 1 H3BUY0;Q7Z2W9-2;Q7Z2W9 H3BUY0 MRPL21 39S ribosomal protein L21, mitochondrial 0 6117400.0 3233600.0 1760700.0 1123100.0 False True 3130951.1379831494 2463756.6919292016 828926.4177222092 1.0 0.786903590426604 0.264752268940286 21.578169563096363 -6.955890439434566 0.48992926130194975 1.0114342103170137 0.01808270235949929 0.9995861226745255 0.006283769820014162 0.08120312854518884 0.026814200133705526 0.007516735032262735 0.043065489713544736 1.106902989970116e-07 6.955890439434566 -0.9933515079575145 down VLLVGADNFTLLGKPLLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLLVGADNFTLLGKPLLGK 19 1 H3BUY0;Q7Z2W9-2;Q7Z2W9 H3BUY0 MRPL21 39S ribosomal protein L21, mitochondrial 0 6513300.0 3233600.0 1495000.0 1784700.0 False True 2688881.672768887 1486946.1382657331 2157872.5184795447 1.0 0.5529979817723046 0.8025167266871459 21.35857483853064 -10.134210759959503 5.356065693184426 1.0000074294894197 0.6777573542295864 0.689808382445326 0.10186560105066035 9.037442571975265e-06 1.4607096769365974e-06 0.09863321841345808 0.032876981368314226 7.341575003871102e-11 10.134210759959503 -0.3222500752598333 VLLVIDEPHTDWAKYFKGK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLLVIDEPHTDWAKYFKGK 19 2 P17600-2;P17600 P17600-2 SYN1 Synapsin-1 1 32915200.0 8307200.0 11632000.0 12976000.0 True False 12602629.737669636 9556178.718769183 10411287.912417147 1.0 0.7582686246986595 0.8261202724457973 23.58722147044766 -10.138643573036584 6.031924323761428 1.0000013244034796 0.7921944485722255 0.9259610094693581 0.027700319197935933 4.933605327324863e-07 7.046568346789632e-08 0.026820889580803343 0.008940239578184718 7.267021196751364e-11 10.138643573036584 -0.207806875831254 VLLVIDEPHTDWAKYFKGK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLLVIDEPHTDWAKYFKGK 19 2 P17600-2;P17600 P17600-2 SYN1 Synapsin-1 1 21078900.0 8307200.0 6222200.0 6549500.0 True False 10753834.159393005 5875929.100246607 5357558.203545021 1.0 0.5464031724084418 0.49819981637576466 23.35834779254011 -13.999999999999998 0.3166647855705977 5.559884315084189 0.4882697716403558 0.9996865394786094 0.0040021245215671455 17.758163922533875 0.1793147339978764 53.55029202532157 0.01626100815105775 1.0000000000000041e-14 13.999999999999998 -5.071614543443833 VLLVLELQGLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLLVLELQGLQK 12 0 Q14697;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 23567500.0 10602000.0 5240800.0 7724700.0 False True 10265445.313241389 7333478.770410946 5701369.333967365 1.0 0.7143848655987186 0.5553942532442478 23.291292876876764 -13.532342514102167 0.07285935596523825 2.5289371207549887 4.757942883405015e-21 0.9999240100026854 0.0016034963171423396 10.490419270759354 0.06918525361175308 2.8152833711721788 0.4854048632260981 2.9353337354445897e-14 13.532342514102167 -2.5289371207549887 VLLVLELQGLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLLVLELQGLQK 12 0 Q14697;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 477440000.0 119300000.0 187010000.0 171130000.0 False True 180986821.99826494 153636604.38420087 137306080.49105653 1.0 0.8488828230028468 0.7586523647140058 27.431309414805835 -13.999997414487156 0.053387824508301276 2.0413175304832856 0.2796974260627333 0.9999692616426407 0.0005520043955639399 12.53151276284444 0.05650482573827727 1.855119750291194 0.4551243290843777 1.0000059533810533e-14 13.999997414487156 -1.7616201044205524 VLLVLELQGLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLLVLELQGLQK 12 0 Q14697;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 24336500.0 10602000.0 4865500.0 8869000.0 False True 8816032.748235943 4839288.5857738685 10723466.89437724 1.0 0.5489190800410982 1.216359693822935 23.07169815231104 -6.724603499560195 1.7423052063688071 0.7269423616570398 1.21563601666087 0.5344248885480565 0.18971607352499156 0.3464082687926901 2.0573636790733723 0.08637031402206165 0.21569314520687607 1.8853696011782414e-07 6.724603499560195 0.4886936550038301 VLLVLELQGLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLLVLELQGLQK 12 0 Q14697;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 364970000.0 119300000.0 108950000.0 136720000.0 False True 154436201.7545725 102886836.72525297 111838362.86566518 1.0 0.6662093185169048 0.724171933750332 27.202435736898284 -10.601945417563833 6.468849070176685 1.0008110979492513 0.6951906261336224 0.9735954286074651 0.023663138579861305 0.0002775013900139918 1.707574841880849e-05 0.022969347330782434 0.007637245136566749 2.50065962660948e-11 10.601945417563833 -0.3056204718156289 VLLYLLSPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLLYLLSPR 9 0 Q15397 Q15397 KIAA0020 Pumilio domain-containing protein KIAA0020 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 VLNEAVGALMYHTITLTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLNEAVGALMYHTITLTR 18 0 Q13363-2;Q13363;D6RAX2;E9PGB1;E7ESU7;E7EPF8 Q13363-2 CTBP1 C-terminal-binding protein 1 0 43186000.0 13193000.0 14322000.0 15671000.0 False True 12774195.436483094 20040849.288243316 11566294.980077246 1.0 1.5688541315883318 0.9054421499646009 23.606729092255147 -6.6796906288804445 1.9026928515573343 1.3600120734814305 0.9079544662788495 0.3228502725780864 0.24110875044460112 0.43920323534369726 3.0738025793007298 0.10168434874375244 0.26832086795484017 2.0907849781359205e-07 6.6796906288804445 -0.45205760720258104 VLNEAVGALMYHTITLTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLNEAVGALMYHTITLTR 18 0 Q13363-2;Q13363;D6RAX2;E9PGB1;E7ESU7;E7EPF8 Q13363-2 CTBP1 C-terminal-binding protein 1 0 38150500.0 8518500.0 11665000.0 17967000.0 False True 12923187.285768818 9583289.610939 14415814.574784163 1.0 0.7415577441559051 1.1154999348078045 23.6234585944819 -6.720792402679816 1.7565757239846655 0.8428969405635398 1.1149378304536803 0.5161694057778221 0.10874332078599559 0.3537979789641751 2.133916327158744 0.04914752226980743 0.12325861249026268 1.9019872325196744e-07 6.720792402679816 0.2720408898901405 VLNEAVGALMYHTITLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLNEAVGALMYHTITLTR 18 0 Q13363-2;Q13363;D6RAX2;E9PGB1;E7ESU7;E7EPF8 Q13363-2 CTBP1 C-terminal-binding protein 1 0 20576400.0 13193000.0 7383400.0 0.0 False True 10970564.048998011 7343624.158709849 0.0 1.0 0.6693934902445215 0.0 23.387134367689423 -7.4919669453479285 0.7187419723760832 0.9928440745336458 4.4109775888476566e-17 0.9871035561730966 0.04724024949191273 0.1186496645942546 0.14206291407610946 0.04164462801029419 0.0753712292380013 3.2213139598604265e-08 7.4919669453479285 -0.9928440745336458 down VLNEAVGALMYHTITLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLNEAVGALMYHTITLTR 18 0 Q13363-2;Q13363;D6RAX2;E9PGB1;E7ESU7;E7EPF8 Q13363-2 CTBP1 C-terminal-binding protein 1 0 29910500.0 8518500.0 12456000.0 8936000.0 False True 11027366.17473869 11762812.650295999 7309739.6911028735 1.0 1.0666928497615376 0.662872672882479 23.39458491657435 -6.864485413777482 1.1627838139059419 1.036717648576197 0.6415666138307425 0.9588674951087578 0.03584747059026664 0.14225682076808238 0.362959867241204 0.023996361207043793 0.05633202518262584 1.366200960170636e-07 6.864485413777482 -0.39515103474545454 VLNGEK(ub)VDVRPATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLNGEKVDVRPATR 14 2 Q8N684-2;Q8N684;Q8N684-3;F5H669;J3QT54;F5H6M0;F5H047 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 1 4854860.0 1390600.0 2880700.0 583560.0 True False 1156345.5140253631 2865181.0973258177 705579.6979234162 1.0 2.4777897804539526 0.6101806850680964 20.141141106342992 -6.695787200721257 1.8457349787502608 1.9213920693794921 0.6161220194344299 0.3977152800061853 0.6242842122500283 0.404333955173115 2.6748848412724433 0.27013208042767245 0.6983848371845989 2.014711193256018e-07 6.695787200721257 -1.3052700499450622 VLNGEK(ub)VDVRPATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLNGEKVDVRPATR 14 2 Q8N684-2;Q8N684;Q8N684-3;F5H669;J3QT54;F5H6M0;F5H047 Q8N684-2 CPSF7 Cleavage and polyadenylation specificity factor subunit 7 1 6200400.0 1227700.0 2257800.0 2714900.0 True False 1589281.8515849859 2132151.4452342927 2220816.05722641 1.0 1.341581698115979 1.3973708030527103 20.59994357181124 -12.349476311258359 0.283474891208846 5.214088230901117e-12 1.4147039060429514 0.9994818430104135 0.003998455337730742 6.297385763798106 0.1612596346073454 3.6624072328145365 0.021701146537188052 4.4722254503075937e-13 12.349476311258359 1.4147039060377373 VLNGICAYLNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLNGICAYLNR 11 0 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21;A0A590UJ56;A0A590UJA0;A0A590UJM8 A0A590UJC4 CUL1 Cullin-1 0 21856100.0 5766700.0 7459600.0 8629800.0 False True 7560199.544802231 6346656.75729306 7736871.0788869085 1.0 0.8394827040850393 1.0233686337295347 22.849992882936842 -6.676057377290637 1.9163933257724175 0.8980794069018831 1.0226408536717286 0.3060035939592457 0.06809077238132286 0.4473134099594061 3.1727705883881208 0.028549838730437416 0.07566700298785366 2.1083495846201023e-07 6.676057377290637 0.12456144676984549 VLNGICAYLNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLNGICAYLNR 11 0 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21;A0A590UJ56;A0A590UJA0;A0A590UJM8 A0A590UJC4 CUL1 Cullin-1 0 20167000.0 5766700.0 5374000.0 9026300.0 False True 7898804.829207812 5136558.9105584705 6894473.842483793 1.0 0.6502957120252871 0.872850259192346 22.913202944459734 -10.752134379977237 5.741459361309076 1.0090000530713774 0.7615729856090103 0.604790019331986 0.09085751341591097 0.010711177410350154 0.00046241365188631474 0.09002305017397041 0.029324136361470004 1.7695613335728337e-11 10.752134379977237 -0.2474270674623671 VLNGTVEEEDPYQGTIVLATVK(ub)GDVHDIGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLNGTVEEEDPYQGTIVLATVKGDVHDIGK 30 1 Q99707;Q99707-2;B1ANE3 Q99707 MTR Methionine synthase 1 33549900.0 7190900.0 12412000.0 13947000.0 True False 10909121.025208088 10196981.624601359 11190369.336812751 1.0 0.9347207351571989 1.0257810240581962 23.379031529057414 -6.714276890495866 1.7797914446439778 0.9600441740228175 1.0255966259099851 0.4854238102411953 0.027490762361680837 0.3665644080626413 2.265958726976743 0.012279414904569564 0.03103673222966054 1.930736956284924e-07 6.714276890495866 0.06555245188716763 VLNGTVEEEDPYQGTIVLATVK(ub)GDVHDIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLNGTVEEEDPYQGTIVLATVKGDVHDIGK 30 1 Q99707;Q99707-2;B1ANE3 Q99707 MTR Methionine synthase 1 29687300.0 7190900.0 7786400.0 14710000.0 True False 9308761.803830316 7353079.995204309 12032930.93734594 1.0 0.789909565865001 1.2926457020733626 23.150157851149864 -6.793178537239574 1.483440449479368 0.883063801155494 1.2984836718917048 0.8115097811518345 0.08950596900018121 0.23064393209677886 1.0025596815612978 0.04748210090732065 0.11092358304348089 1.609983639371012e-07 6.793178537239574 0.4154198707362108 VLNK(ub)TMDVSK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VLNKTMDVSK 10 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 1 11782390.0 2426160.0 3887200.0 5469030.0 True False 3180719.2549668592 3307244.912186925 4903147.238240155 1.0 1.0397789452880788 1.5415215381186613 21.600921607865722 -6.9226848360963675 0.8045431883345426 0.9899646876564329 1.6276550252338418 0.9948954232972435 0.01760690020762431 0.09661688169320261 0.09760915108747112 0.015390163525821203 0.04735520237954683 1.194854886199287e-07 6.9226848360963675 0.6376903375774089 VLNK(ub)TMDVSK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VLNKTMDVSK 10 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 1 31818480.0 6032830.0 8601100.0 17184550.0 True False 5841321.113854181 12035564.084143957 12683400.829550533 1.0 2.0604181570498756 2.171324017689871 22.477863265288462 -10.83361852665088 0.42234533794338225 2.425400184756314e-25 2.176684274346004 0.9995282868659244 0.011466992981246574 2.4872121180661204 0.20434983610601082 2.519567119784982 0.026676774553235978 1.466835706848265e-11 10.83361852665088 2.176684274346004 VLNK(ub)TMDVSK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VLNKTMDVSK 10 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 1 65219330.0 13613330.0 18275300.0 33330700.0 True False 20652416.877733815 15013929.929429362 26742872.53563524 1.0 0.7269817386659704 1.2949028045462216 24.299807289124452 -6.775979046581207 1.551384441111744 0.8445986042810859 1.2988572322630763 0.7529166297257889 0.1152767079400473 0.25689486860775784 1.2209054204288434 0.05854009861903031 0.13861029210355777 1.675023688994701e-07 6.775979046581207 0.45425862798199035 VLNK(ub)TMDVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VLNKTMDVSK 10 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 1 11104880.0 2426160.0 2924860.0 5753860.0 True False 3323176.91650872 2795630.0139813996 4394916.772466443 1.0 0.841252236705606 1.3225046041435786 21.664131669388613 -6.817813929514353 1.381150721944311 0.9142363183374874 1.332537481513345 0.8792863004348579 0.0695662610228557 0.19635895289699226 0.7365687101249231 0.03958451115313133 0.09130026503710645 1.5211991374485784e-07 6.817813929514353 0.41830116317585764 VLNK(ub)TMDVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VLNKTMDVSK 10 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 1 29416890.0 6032830.0 13963420.0 9420640.0 True False 5016565.4446840435 13888196.284938138 11390452.267882066 1.0 2.768467079335163 2.2705678603181196 22.25826854072274 -10.098869244492759 4.866340377621025 0.9999374124735314 2.51951746983763 0.9254757200650754 0.20326650502491767 0.00013803360507561944 2.5560710006285433e-05 0.1968199534680855 0.06560398239487314 7.963990907247444e-11 10.098869244492759 1.5195800573640987 VLNK(ub)TMDVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VLNKTMDVSK 10 1 P25789;H0YN18;H0YMZ1;H0YL69;H0YMA1;P25789-2;H0YKT8;H0YMI6;H0YKS0 P25789 PSMA4 Proteasome subunit alpha type-4;Proteasome subunit alpha type;Proteasome subunit beta type 1 65495920.0 13613330.0 38306400.0 13576190.0 True False 17622724.04385229 36174615.16596812 11105462.723472906 1.0 2.0527255080401536 0.6301785521828598 24.0709336112169 -6.708460124468898 1.8005723284970163 1.6481921384299905 0.6336484098872641 0.45788523971230743 0.4437187932004116 0.3781560316976257 2.388892909953779 0.1961753013111679 0.4993329981384589 1.9567704240925893e-07 6.708460124468898 -1.0145437285427263 VLNLWQK(ub)NGVFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLNLWQKNGVFK 12 1 O95104-2;O95104-3;O95104 O95104-2 SCAF4 Splicing factor, arginine/serine-rich 15 1 9010010.0 4266400.0 4152600.0 591010.0 True False 3547700.6335666743 4130229.1195734325 714587.4584785097 1.0 1.1641988843407889 0.20142270509451088 21.7584528448339 -6.862977840002547 1.1705178500878723 1.0899021529466757 0.15205985483449208 0.9571629500109744 0.08703799736588039 0.1437701826027443 0.3726130992558645 0.05791943538441918 0.13569476238315017 1.3709517175751682e-07 6.862977840002547 -0.9378422981121837 down VLNNMEIGTSLFDEEGAK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VLNNMEIGTSLFDEEGAK 18 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 202020200.0 43767200.0 78329400.0 79923600.0 False True 57379223.042167746 66642958.84560986 71653872.55330667 1.0 1.1614475643323758 1.2487773231200525 25.774025097274535 -13.999999999999964 0.07528144674861617 0.10224750409303283 1.5339581245208889 0.999905402858364 0.001002301804730138 12.305985038796868 0.07579925755642966 1.8828710318247666 0.2606130945800636 1.0000000000000819e-14 13.999999999999964 1.431710620427856 VLNNMEIGTSLFDEEGAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VLNNMEIGTSLFDEEGAK 18 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 261108200.0 98441000.0 54366200.0 108301000.0 False True 95316044.33887899 76074907.17598756 79933719.139643 1.0 0.7981332807467015 0.8386176712857816 26.50621574445249 -10.483685754294315 6.123744359326578 1.0001251405442078 0.818375476016242 0.9640748728894518 0.01652768322805086 2.825703830627803e-05 2.382454276113784e-06 0.016013836662061815 0.0053342868244693736 3.283327813878937e-11 10.483685754294315 -0.1817496645279657 VLNNMEIGTSLFDEEGAK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VLNNMEIGTSLFDEEGAK 18 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 397110000.0 53627000.0 282508000.0 60975000.0 False True 81356079.65885131 232092240.15492153 48923264.52370815 1.0 2.852795281288736 0.6013473698444789 26.277746825302202 -6.6880759246152905 1.8732485281740365 2.1636817567820956 0.6093090657496985 0.3614130370362768 0.7839124697489459 0.4208315692088076 2.861579913126895 0.334964580642498 0.8743938359778332 2.0508036200740722e-07 6.6880759246152905 -1.5543726910323972 VLNNMEIGTSLFDEEGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VLNNMEIGTSLFDEEGAK 18 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 217392000.0 43767200.0 64183800.0 109441000.0 False True 59949116.60410716 61347947.488556564 83593289.80814601 1.0 1.023333636318397 1.3944040303409404 25.837235158797426 -6.9197260655862225 0.8267407689297688 0.9917316590408156 1.4538700989439746 0.9941048623296838 0.013872215932400213 0.09833314991588557 0.10644625601504018 0.011935062846446572 0.035658918260681884 1.2030230108968313e-07 6.9197260655862225 0.46213843990315895 VLNNMEIGTSLFDEEGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VLNNMEIGTSLFDEEGAK 18 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 185961400.0 98441000.0 44873400.0 42647000.0 False True 81858053.17573044 44631658.087527506 51564290.52255123 1.0 0.5452323425248532 0.6299232454484905 26.286621019886766 -10.44185543006542 6.678249484219331 1.0000772519696528 0.587577793986705 0.9693430996019607 0.03457491633641593 3.977587062678106e-05 3.3243314453520643e-06 0.0334832419670887 0.011159006263954465 3.6153019043511636e-11 10.44185543006542 -0.41249945798294785 VLNNMEIGTSLFDEEGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VLNNMEIGTSLFDEEGAK 18 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 200525700.0 53627000.0 92384000.0 54514700.0 False True 69421208.64620675 87242749.18793717 44593583.96805791 1.0 1.2567160798446313 0.642362540752084 26.04887314739465 -6.793208205523718 1.483560645602047 1.1428810113810535 0.635244726182967 0.8115398383465657 0.10936970925296209 0.2305966355452847 1.0025526025199056 0.05801792141360562 0.13551953653745966 1.609873659109717e-07 6.793208205523718 -0.5076362851980865 VLNNMEIGTSLFDEEGAK(ub)IVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLNNMEIGTSLFDEEGAKIVK 21 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 10150600.0 3015600.0 2784600.0 4350400.0 True False 2919871.428655981 3896505.3014971605 3210899.7307975213 1.0 1.334478382594649 1.0996716154298276 21.47747341331844 -10.30670663403873 4.053010272298128 0.9996714674100783 1.2170749990232472 0.5326141440145725 0.09585946142780725 68092093.5372223 114.66142206181685 213677.7859804171 0.03281524333659922 4.935070554465397e-11 10.30670663403873 0.21740353161316894 VLNNMEIGTSLFDEEGAK(ub)IVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLNNMEIGTSLFDEEGAKIVK 21 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 21755000.0 4351600.0 7149400.0 10254000.0 True False 6601695.344573765 5873533.711482842 8227292.405512147 1.0 0.8897008124300325 1.2462393333970696 22.65440513184493 -6.823619507205346 1.356115836826037 0.9407570448460199 1.2546457213285132 0.8925127661692811 0.04886351400349528 0.18881852942329752 0.6813060668757344 0.02830724952037255 0.0651901094312367 1.5009993106697944e-07 6.823619507205346 0.3138886764824933 VLNNMEIGTSLFDEEGAK(ub)IVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLNNMEIGTSLFDEEGAKIVK 21 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 22097200.0 4351600.0 9286400.0 8459200.0 True False 5633231.98286 8769603.676598327 6919712.398721742 1.0 1.5567623884976218 1.2283734133044872 22.425531453937378 -10.286244097104289 5.112631027193555 0.9999119564343371 1.3925679009009966 0.6558159168858464 0.13406423773010548 0.0001345861194373407 1.878885618729243e-05 0.12983611361180158 0.04326904667084376 5.1731599051923055e-11 10.286244097104289 0.3926559444666595 VLNNMEIGTSLFDEEGAKIVK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLNNMEIGTSLFDEEGAKIVK 21 1 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 1 15852300.0 3177500.0 5037900.0 7636900.0 True False 4113336.3878889773 4757536.436329978 6247062.561211236 1.0 1.1566125372915617 1.518733692582171 21.971877629320655 -6.957112434480264 0.4743810350663361 0.9908314553638172 1.6994699921142626 0.9996476582287647 0.00407778132324171 0.0807492037771252 0.02506840930119631 0.005049064658382878 0.02987953399009394 1.1037928220310197e-07 6.957112434480264 0.7086385367504454 VLNSYWVGEDSTYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLNSYWVGEDSTYK 14 0 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 34183700.0 8573700.0 14957000.0 10653000.0 False True 11240203.727828901 12725473.901929349 9550729.750791702 1.0 1.1321390795100237 0.8496936516502509 23.422164848744114 -6.779451498357547 1.5377227618916829 1.0748711876668888 0.8474826093778992 0.7655707424077974 0.055868123535676086 0.25140965861236486 1.1741347149901982 0.028615239906206364 0.06755901342117608 1.661684242903185e-07 6.779451498357547 -0.22738857828898962 VLNSYWVGEDSTYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLNSYWVGEDSTYK 14 0 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 25126600.0 9422100.0 3217500.0 12487000.0 False True 9123000.592896778 4502264.529040839 9216280.09802976 1.0 0.4935069863468307 1.0102246518766655 23.121076980173683 -10.794458611646894 11.530036618890792 1.0010587339965589 0.7518658191117481 0.23516515405173855 0.21094910360503322 0.005761080050581196 0.00010270038841154444 0.2049603036431536 0.06808353042997303 1.6052452310070077e-11 10.794458611646894 -0.24919291488481077 VLNSYWVGEDSTYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLNSYWVGEDSTYK 14 0 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 35203700.0 8573700.0 13839000.0 12791000.0 False True 11743628.585530557 13227547.220546843 9770029.238914086 1.0 1.1263594658336382 0.8319429695649466 23.485374910267005 -6.790078513291403 1.4960617930754665 1.0706145298365601 0.8288065663601677 0.8015728949046523 0.05371975915995537 0.23523041470073455 1.0401107588192862 0.028263521461197948 0.06616683601779383 1.6215169272983824e-07 6.790078513291403 -0.24180796347639244 VLNSYWVGEDSTYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLNSYWVGEDSTYK 14 0 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 16688500.0 9422100.0 4389800.0 2876600.0 False True 7834893.61980323 4366151.276092923 3478083.7601043642 1.0 0.557270013859177 0.44392226989697336 22.90148225560796 -13.9999999999999 0.19130773703673615 3.3841194239305707 0.3636668255100632 0.9994887415758295 0.005424967601324008 12.372316771004934 0.13870562624901758 11.000531385751371 0.07714780267691689 1.0000000000002291e-14 13.9999999999999 -3.0204525984205075 VLNTNIDGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLNTNIDGR 9 0 P62269;A0A0G2JQH2;Q5GGW2 P62269 RPS18 40S ribosomal protein S18 0 12499300.0 3476400.0 1408200.0 7614700.0 False True 3366043.5848851535 1970501.603665989 5620181.633896626 1.0 0.5854058493224237 1.669669893501507 21.68262242670819 -6.80305884562301 1.443312563795753 0.772128110364548 1.685806221523459 0.8409737386573641 0.17814074486340847 0.21642185712806655 0.8897091392784461 0.09708203632619347 0.2253776784307775 1.5737696088725963e-07 6.80305884562301 0.9136781111589111 VLNTSLK(ub)EK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLNTSLKEK 9 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 2338990.0 807630.0 902840.0 628520.0 True False 1058810.7511000456 768139.7912427555 563486.7795895621 1.0 0.7254741137117288 0.5321883811664461 20.0140133183823 -7.728770612194854 0.12189662642492323 1.3991356842974714 5.290619722165294e-12 0.999987918058983 0.0006671438193933495 0.13487302437103363 0.014983790755098661 0.06843903814252497 0.09316246646779812 1.8673657448674142e-08 7.728770612194854 -1.3991356842921807 VLNTSLK(ub)EK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLNTSLKEK 9 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 9373960.0 1194340.0 1794020.0 6385600.0 True False 1156426.3304486645 2510381.5416907077 4713019.796106259 1.0 2.17080973996566 4.075503706559263 20.141241932071605 -6.96387334515663 0.3768881134074932 0.8645009470920253 5.448836069827939 0.9998880046346522 0.013412924888626438 0.07834538302824003 0.016220884659607176 0.024873063086563268 0.16118952809405143 1.0867425079879747e-07 6.96387334515663 4.584335122735913 VLNTSLK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLNTSLKEK 9 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 33038480.0 711280.0 1484200.0 30843000.0 True False 1079063.7615333293 1219332.9138924705 24746867.53103289 1.0 1.129991532807868 22.93364712375111 20.04134868505844 -6.908206515448144 0.9078451005369927 0.28602738481246043 25.646077229144286 0.9902273694381105 1.019124492267005 0.10561644062747966 0.14528255839294765 0.8270414641837002 2.255657770240008 1.2353598561852223e-07 6.908206515448144 25.360049844331826 up VLNTSLK(ub)EK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLNTSLKEK 9 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 6783740.0 1194340.0 1276000.0 4313400.0 True False 993146.6282331762 1269125.9347338318 5215311.997091765 1.0 1.2778837471276796 5.2513011158985545 19.92164720750588 -6.9210199433374 0.8171199539253846 0.9155087949121827 5.907341274632387 0.9944596335553314 0.14454277845328511 0.09757573643199587 0.10252998400060268 0.12521522098865026 0.37881939126930475 1.1994442219290223e-07 6.9210199433374 4.991832479720204 up VLNTSLK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLNTSLKEK 9 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 67803480.0 711280.0 1020200.0 66072000.0 True False 920765.9814249168 963424.973172125 54047573.95597011 1.0 1.0463298955519533 58.69849130647686 19.81247500715089 -6.902256394193363 0.9482382596366217 2.3058714115877706e-15 65.00363888518524 0.9896928621711774 2.7602788048550764 0.10379430600035319 0.1596514179493933 2.232471804120062 5.868133107350054 1.252401577017732e-07 6.902256394193363 65.00363888518524 up VLPEK(ub)LGVDLDAQTWR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLPEKLGVDLDAQTWR 16 1 P22102 P22102 GART Trifunctional purine biosynthetic protein adenosine-3;Phosphoribosylamine--glycine ligase;Phosphoribosylformylglycinamidine cyclo-ligase;Phosphoribosylglycinamide formyltransferase 1 35714200.0 3745100.0 7438100.0 24531000.0 True False 5681590.503484516 6110712.9408594435 19682437.097680762 1.0 1.0755285755127453 3.4642477464029717 22.437863423399744 -6.913636891977648 0.8705992239574722 0.9342734899467332 3.79822814518398 0.9922232329065189 0.10090864113258416 0.10206195716875192 0.12608451414494612 0.08413057681295373 0.2385300737208158 1.2200092066082584e-07 6.913636891977648 2.863954655237247 up VLPGSSVLFLCDMQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLPGSSVLFLCDMQEK 16 0 Q96AB3-3;Q96AB3;Q96AB3-2;K7ENV7;K7EKW4 Q96AB3-3 ISOC2 Isochorismatase domain-containing protein 2, mitochondrial 0 2984470.0 547170.0 1207700.0 1229600.0 False True 717345.1688018182 1027515.8675777297 1102372.7871560585 1.0 1.4323869627420642 1.536739682790855 19.452307949700383 -11.97570066970678 0.23543852745208982 6.112859628356451e-14 1.5899392490107904 0.9993663125601514 0.005849332031444964 5.127938510357409 0.1396488492776958 2.5553356872221977 0.05223595380432161 1.057546154288241e-12 11.97570066970678 1.5899392490107294 VLPGVDALSNI ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLPGVDALSNI 11 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 30862400.0 16766400.0 3207000.0 10889000.0 False True 16234159.809463374 4487571.824284062 8036844.237002174 1.0 0.27642772258950676 0.49505760269264193 23.95252938483265 -10.274247317195526 5.175695567509675 1.0001076644770004 0.3857426626415517 0.913231794457039 0.08925527479684942 0.00011090590450621598 1.5551680845862294e-05 0.08643604979188539 0.028807016070719216 5.3180532643187444e-11 10.274247317195526 -0.6143650018354487 VLPLSVTHFYSATK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLPLSVTHFYSATK 14 0 A0A087X0R1;A0A087WZN3;Q6UWP2-2;Q6UWP2-3;Q6UWP2 A0A087X0R1 DHRS11 Dehydrogenase/reductase SDR family member 11 0 3986600.0 1236100.0 1317600.0 1432900.0 False True 1620539.0704094283 1121019.2159645727 1284637.2533473598 1.0 0.6917569816328759 0.7927221730129573 20.628042373075537 -10.695938415303994 9.741992192428116 1.0002812228797264 0.7422395773229167 0.8968025466933284 0.041218866777275 0.0002520303782061982 7.866183228262833e-06 0.03995195001082105 0.013303332048160692 2.014009824269236e-11 10.695938415303994 -0.25804164555680975 VLPLSVTHFYSATK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLPLSVTHFYSATK 14 0 A0A087X0R1;A0A087WZN3;Q6UWP2-2;Q6UWP2-3;Q6UWP2 A0A087X0R1 DHRS11 Dehydrogenase/reductase SDR family member 11 0 4321300.0 1236100.0 1445500.0 1639700.0 False True 1693119.5743464704 1381633.0303707228 1252436.6306815292 1.0 0.8160280297415031 0.7397213106847217 20.69125243459843 -13.999999999836968 0.12077101241293722 1.876363838001374 0.6191868718395825 0.9996891647280277 0.0019260660154962286 11.960848248073708 0.10705159395050438 2.5132958261598333 0.10696686490821011 1.0000000003753957e-14 13.999999999836968 -1.2571769661617915 VLPSITTEILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLPSITTEILK 11 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2 P35232 PHB Prohibitin 0 59255000.0 16992000.0 19410000.0 22853000.0 False True 22276676.550762057 16514103.659587424 20488390.781455275 1.0 0.7413181055960746 0.9197238526477771 24.409030677797112 -10.077752886328664 5.053867347546718 1.0000036999969815 0.8305209794084223 0.546123373335159 0.0728338412449705 3.0364817892997027e-06 5.54155059072575e-07 0.07052260292827461 0.023507021181527404 8.360786118560622e-11 10.077752886328664 -0.16948272058855918 VLPSITTEILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLPSITTEILK 11 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2 P35232 PHB Prohibitin 0 59600000.0 27964000.0 11325000.0 20311000.0 False True 27076298.12671968 15847131.559094805 14990939.783060992 1.0 0.5852768899547754 0.5536554411131814 24.690527171244995 -13.999999999999998 0.3650514920307839 6.60022051101733 0.5501191361042029 0.9997823089343975 0.003000525366727579 22.252513439806908 0.19568030712128112 97.30856226737862 0.008976894250670032 1.0000000000000041e-14 13.999999999999998 -6.050101374913127 VLPSITTEILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLPSITTEILK 11 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2 P35232 PHB Prohibitin 0 53119400.0 6269800.0 40123000.0 6726600.0 False True 9511744.983778067 32962737.16757017 5397084.561626481 1.0 3.4654773886165904 0.5674126641148403 23.181278605310744 -6.681341414013402 1.897168120534784 2.5580458235635235 0.5783343284486621 0.33028082443342655 1.0446206092166899 0.43553457519252026 3.0319543411732464 0.44164259681399404 1.1627848827288956 2.0828528361839187e-07 6.681341414013402 -1.9797114951148616 VLPSITTEILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLPSITTEILK 11 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2 P35232 PHB Prohibitin 0 72246000.0 16992000.0 24156000.0 31098000.0 False True 23274401.59153402 23088708.04679017 23753292.883414168 1.0 0.9920215544956742 1.0205758798995006 24.472240739320004 -6.832144815485711 1.3184401032433128 0.9957429097987965 1.021377692524419 0.9100706086464712 0.0036074189228035578 0.17818024596349308 0.6050069437582992 0.0021478862847270114 0.004942452034659561 1.4718216417035385e-07 6.832144815485711 0.025634782725622363 VLPSITTEILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLPSITTEILK 11 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2 P35232 PHB Prohibitin 0 52322000.0 27964000.0 10651000.0 13707000.0 False True 23253305.015248988 10593620.948942035 16573070.325992677 1.0 0.4555748501984978 0.7127189152305203 24.47093244667927 -10.420743949127822 6.082689790627991 1.000124596285314 0.5841468827145128 0.7771394061759932 0.10497862495225192 0.00017743214366524522 1.689695336389438e-05 0.10167525854152407 0.03388170551231878 3.795386870318947e-11 10.420743949127822 -0.41597771357080127 VLPSITTEILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLPSITTEILK 11 0 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2 P35232 PHB Prohibitin 0 25692500.0 6269800.0 11123000.0 8299700.0 False True 8116379.696234873 10503995.272097183 6789239.7621135395 1.0 1.2941724839425524 0.8364862187587179 22.952404927403194 -6.733135305381802 1.711716724253849 1.1764114384406235 0.8365954473241671 0.573750436083097 0.12363586344390068 0.330404337829707 1.8979126633176089 0.05720501250565953 0.14145371520509425 1.8486925650944766e-07 6.733135305381802 -0.33981599111645633 VLPSITTEILK(ub)SVVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLPSITTEILKSVVAR 16 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2 P35232 PHB Prohibitin 1 5777800.0 1223800.0 1981800.0 2572200.0 True False 1604413.6512960582 1686123.1649958964 2306053.4182846555 1.0 1.050927959652944 1.4373184972726996 20.613614715940354 -6.931095343869512 0.7377387125319901 0.9943567554386238 1.5189033852550704 0.99674934939289 0.011132654474082708 0.09207269419098685 0.07492094352520562 0.010209349796766758 0.03475337172509935 1.1719380531032307e-07 6.931095343869512 0.5245466298164466 VLPSITTEILK(ub)SVVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLPSITTEILKSVVAR 16 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2 P35232 PHB Prohibitin 1 20598600.0 5497400.0 4521200.0 10580000.0 True False 5322888.04612462 6326538.737746525 7808780.606803466 1.0 1.188553785637596 1.4670195087963052 22.343777792360193 -6.965514569235333 0.349111036846263 0.9728129003469096 1.6921439737369455 0.9999233592957811 0.0016793955372377818 0.07778680952300183 0.014246861996392843 0.0038311015231731857 0.023949068843835394 1.0826433951839451e-07 6.965514569235333 0.7193310733900359 VLPSITTEILK(ub)SVVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLPSITTEILKSVVAR 16 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2 P35232 PHB Prohibitin 1 54651600.0 9659600.0 13933000.0 31059000.0 True False 14654319.411353229 11446547.290974138 24920175.0363567 1.0 0.7811039850889346 1.700534452459808 23.804822630897064 -6.843891984455168 1.264220299000651 0.883547273769233 1.7331776245031791 0.9309413371669271 0.10305247826345378 0.16429810437111683 0.5083966078967178 0.06387419905399963 0.14734221295320424 1.4325441501636835e-07 6.843891984455168 0.8496303507339461 VLPSITTEILK(ub)SVVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLPSITTEILKSVVAR 16 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2 P35232 PHB Prohibitin 1 12920300.0 1223800.0 2232700.0 9463800.0 True False 1676271.931951468 2134051.9314484373 7228645.353079137 1.0 1.273094114845695 4.312334541486806 20.676824777463246 -6.9245101336292185 0.7905544462715565 0.9431996874124323 4.857168203040571 0.9953448327296011 0.10242684624188592 0.09559029323814602 0.0923908808819091 0.09042918635885691 0.2837510192142275 1.189843565569444e-07 6.9245101336292185 3.9139685156281385 up VLPSITTEILK(ub)SVVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLPSITTEILKSVVAR 16 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2 P35232 PHB Prohibitin 1 21114800.0 5497400.0 5625700.0 9991700.0 True False 4571331.676113213 5595393.237485984 12080918.27359895 1.0 1.2240182148068246 2.642756887828971 22.12418306779447 -6.9347029193499585 0.707130136235068 0.9817240415689739 2.9722632508769253 0.9973844145073109 0.03719992866919393 0.09026839644168605 0.0662507591028062 0.03489480796352484 0.12521856982070204 1.1622433786018786e-07 6.9347029193499585 1.9905392093079515 up VLPSITTEILK(ub)SVVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLPSITTEILKSVVAR 16 1 P35232;C9JW96;E9PCW0;C9JZ20;E7ESE2;P35232-2 P35232 PHB Prohibitin 1 36865600.0 9659600.0 10214000.0 16992000.0 True False 12504542.61918247 9645581.9211724 13899630.35264324 1.0 0.7713662318504709 1.1115664743563392 23.575948952989513 -6.7256340312444305 1.7390582345890735 0.8617441220046888 1.11121108215445 0.5389306061371527 0.0961497982617631 0.3444954629997706 2.0389893008381277 0.04385025452516097 0.10935718486710028 1.8809011360391578e-07 6.7256340312444305 0.24946696014976133 VLPSIVNEVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLPSIVNEVLK 11 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6 Q99623 PHB2 Prohibitin-2 0 29904700.0 7408400.0 13299000.0 9197300.0 False True 9712484.143047655 11314841.039095974 8245651.622731301 1.0 1.164979100346363 0.848974526113761 23.211408907450423 -6.764814253096397 1.5941260107795008 1.0952521384339446 0.8475276958282513 0.7104002116176292 0.06944771285371315 0.2748987544831047 1.3777803091583045 0.03435475970233224 0.08217967173796918 1.7186432903742333e-07 6.764814253096397 -0.24772444260569337 VLPSIVNEVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLPSIVNEVLK 11 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6 Q99623 PHB2 Prohibitin-2 0 28033000.0 11535000.0 7825100.0 8672900.0 False True 11168827.738939783 10949703.23735743 6401207.308577108 1.0 0.980380707205432 0.5731315280528047 23.412974435174338 -6.916935558134763 0.8471388409128425 1.0100159343109867 0.5118738437294785 0.9932865586757365 0.016122178816266635 0.10000873273564455 0.1152037537093968 0.01367002800151339 0.03982214162176287 1.2107777789137727e-07 6.916935558134763 -0.49814209058150816 VLPSIVNEVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLPSIVNEVLK 11 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6 Q99623 PHB2 Prohibitin-2 0 34192000.0 7408400.0 9524600.0 17259000.0 False True 10147485.684482154 9103771.678359732 13182779.660262562 1.0 0.8971455552069907 1.2991178376750088 23.274618968973314 -6.838832938241965 1.2878385368831151 0.9452733774135895 1.3120337645034257 0.9224243763003503 0.047488341747202206 0.17016551433996843 0.5487332042536432 0.028920186323537038 0.06660587193614835 1.4493292654877093e-07 6.838832938241965 0.36676038708983616 VLPSIVNEVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLPSIVNEVLK 11 0 Q99623;J3KPX7;F5GY37;Q99623-2;F5GWA7;F5H3X6 Q99623 PHB2 Prohibitin-2 0 23079800.0 11535000.0 4461900.0 7082900.0 False True 9591863.5871441 4437862.859082197 8563901.642370563 1.0 0.4626695134645399 0.8928297993988045 23.193379710608614 -9.959882859383796 6.891463588762241 1.000000021890919 0.6777496564316744 0.4280096674884073 0.1756122013581141 5.901932580528808e-08 8.823893635960695e-09 0.17003579294760005 0.05667859427089936 1.0967739849698146e-10 9.959882859383796 -0.3222503654592447 VLPTTMMFSMLADCVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLPTTMMFSMLADCVLK 17 0 Q2M2E5 Q2M2E5 C5orf64 Uncharacterized protein C5orf64 0 11175300.0 3844700.0 3128900.0 4201700.0 False True 3722652.102982378 4378286.086997945 3101148.721701899 1.0 1.1761201331411844 0.8330482236622203 21.827899366079254 -6.767177707287435 1.5853948157326259 1.1013821545226479 0.8313272675991031 0.719598784777212 0.07417390912258948 0.2710177841790999 1.3439441407186354 0.03688841136425328 0.08803412933419612 1.7093157436426506e-07 6.767177707287435 -0.27005488692354473 VLPTTMMFSMLADCVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLPTTMMFSMLADCVLK 17 0 Q2M2E5 Q2M2E5 C5orf64 Uncharacterized protein C5orf64 0 7571400.0 1805000.0 2539900.0 3226500.0 False True 2472357.278290898 2427678.8196738833 2464467.151853357 1.0 0.981928801711094 0.9968086625234863 21.237455810290385 -9.987811803036866 4.329681765766748 1.0000004406890708 0.989368732114104 0.4049848347266224 0.006074677749737676 180686579514.65427 42247132982.759895 837327.4476439804 0.0020771856595316962 1.0284618747535754e-10 9.987811803036866 -0.010631708574966758 VLPYPFTHHWQFER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLPYPFTHHWQFER 14 0 Q9BVJ6-3;Q9BVJ6;Q9BVJ6-2 Q9BVJ6-3 UTP14A U3 small nucleolar RNA-associated protein 14 homolog A 0 4166330.0 961030.0 1177600.0 2027700.0 False True 1259919.6366277577 1001906.6702488489 1817893.055071844 1.0 0.7952147431644971 1.4428642924699007 20.264900284369915 -6.821679298968782 1.3645515975678515 0.8898054110424751 1.4575239533325 0.8882127600495583 0.09037075945723155 0.19130655658418333 0.6994704486976998 0.05203661867018773 0.1198881091311008 1.5077200181130473e-07 6.821679298968782 0.5677185422900248 VLPYPFTHHWQFER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLPYPFTHHWQFER 14 0 Q9BVJ6-3;Q9BVJ6;Q9BVJ6-2 Q9BVJ6-3 UTP14A U3 small nucleolar RNA-associated protein 14 homolog A 0 5488530.0 961030.0 2735400.0 1792100.0 False True 1316348.7618592242 2614540.983241842 1368842.8894580503 1.0 1.9862068921226 1.0398785862226079 20.328110345892807 -6.63657583765753 2.0573008749817374 1.6466135087315235 1.043821386541041 0.1414192863716166 0.42233681791280425 0.5420717970083252 4.380774453761874 0.1674409290691432 0.4675483726042299 2.3090012197786658e-07 6.63657583765753 -0.6027921221904824 VLQATVVAVGSGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLQATVVAVGSGSK 14 0 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 0 960630000.0 316770000.0 358710000.0 285150000.0 False True 415288537.60504353 305191866.2406285 255645413.35194373 1.0 0.7348911385820104 0.6155850455835914 28.62953881152962 -13.999999999999998 0.10782305863603661 2.2843877836495 0.38970026798767526 0.9997541276165823 0.0025191216974607337 12.02590584601658 0.09927930028417156 3.3766610045472203 0.2007571769218309 1.0000000000000041e-14 13.999999999999998 -1.8946875156618248 VLQATVVAVGSGSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLQATVVAVGSGSK 14 0 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 0 509341780.0 168728780.0 88943000.0 251670000.0 False True 163372577.23636484 124458403.73161764 185750077.06183624 1.0 0.7618071884337921 1.1369721908291621 27.283590600567205 -6.735161643306429 1.704487895276733 0.8574873411283848 1.1369650190247798 0.5830043138162826 0.10009641951092127 0.3266378604455639 1.86134997035818 0.046495395786450545 0.11470370833015985 1.8400869982774088e-07 6.735161643306429 0.279477677896395 VLQATVVAVGSGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLQATVVAVGSGSK 14 0 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 0 1594756100.0 264821100.0 855920000.0 474015000.0 False True 401752969.7157151 703174388.6665167 380325727.48184484 1.0 1.7502655653400414 0.9466656282614851 28.58173344728875 -6.6616272767640785 1.9672896181460124 1.482288780125093 0.9500152867631824 0.24251965811380083 0.31932209914443377 0.48056555689017283 3.577133169037787 0.1310658440889782 0.3540130005741913 2.179579543835143e-07 6.6616272767640785 -0.5322734933619107 VLQATVVAVGSGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLQATVVAVGSGSK 14 0 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 0 1048848400.0 316770000.0 317830000.0 414248400.0 False True 433888429.3873725 303787219.67673963 316411459.6335998 1.0 0.7001505435525698 0.7292461338053104 28.692748873052512 -10.162907845794622 5.630541277873427 1.0000055210565448 0.7146983386789182 0.9922601479681258 0.011878224980795646 8.23249817749983e-07 1.2239340666558392e-07 0.011501264276115149 0.0038336806277493047 6.872142465277207e-11 10.162907845794622 -0.28530718237762664 VLQATVVAVGSGSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLQATVVAVGSGSK 14 0 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 0 415818780.0 168728780.0 138920000.0 108170000.0 False True 140305456.52234486 138171610.3865388 130787846.87842907 1.0 0.9847914244485123 0.9321650783952224 27.06399587600148 -6.948206467770591 0.5782076150794019 1.0006333807153036 0.9137281819971035 0.9990528044891769 0.0008944687177927614 0.084214247861146 0.039006713248305416 0.0009389964421177639 0.004394044850859309 1.1266617030328226e-07 6.948206467770591 -0.08690519871820013 VLQATVVAVGSGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLQATVVAVGSGSK 14 0 P61604;B8ZZL8;S4R3N1 P61604 HSPE1;HSPE1-MOB4 10 kDa heat shock protein, mitochondrial 0 1192994000.0 264821100.0 554270000.0 373902900.0 False True 342816134.35429925 523424387.25751257 305856408.76773417 1.0 1.5268370849679884 0.8921879051691093 28.3528597693812 -6.686344085610078 1.8796232234196475 1.331421500276835 0.8944851411642072 0.35329458922274815 0.22298343185963043 0.4245621766860777 2.9052863418090804 0.09501138547209484 0.24854267994946594 2.0589979507977378e-07 6.686344085610078 -0.43693635911262785 VLQDMGLPTGAEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLQDMGLPTGAEGR 14 0 Q12906-7;Q12906;Q12906-6;Q12906-4;Q12906-3;Q12906-2;Q12906-5 Q12906-7 ILF3 Interleukin enhancer-binding factor 3 0 10531300.0 3743800.0 1527100.0 5260400.0 False True 3624955.1182525144 2136878.993721296 3882543.431382695 1.0 0.5894911589281755 1.0710597248040843 21.789531702086126 -6.680930128493989 1.8986167699424186 0.7404842647902944 1.0692392794690047 0.3283911388199351 0.1739478813198149 0.43644831864669154 3.0426015712988295 0.07349446313437624 0.19360362494481473 2.084826273575738e-07 6.680930128493989 0.32875501467871027 VLQGDLVMNVYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLQGDLVMNVYR 12 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 4923700.0 1322800.0 1658500.0 1942400.0 False True 1734203.6100134214 1411058.2647823652 1741419.0808164661 1.0 0.8136635494441421 1.0041606826103822 20.72584186229671 -11.040416065551462 9.54307304294951 1.2213880014862666 0.9089121160265778 0.23362709718222385 0.07777012895338437 0.052348041712902416 0.0002217004373085147 0.010760755257195966 0.025100201189071754 9.111375273473767e-12 11.040416065551462 -0.31247588545968874 VLQGDLVMNVYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLQGDLVMNVYR 12 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 7794800.0 2078100.0 1714100.0 4002600.0 False True 2012131.852994428 2398549.0689134127 2954198.9845738737 1.0 1.1920436850815337 1.4681935382005278 20.940293415933056 -6.965949981399439 0.341359474542326 0.9705153708918894 1.6989179557387548 0.9999314050401331 0.0015915356629623047 0.07764010739788291 0.013731672252278069 0.0038822505905739117 0.02387831903203152 1.0815585094725176e-07 6.965949981399439 0.7284025848468654 VLQGDLVMNVYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLQGDLVMNVYR 12 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 44323400.0 9133400.0 21090000.0 14100000.0 False True 13856035.540980332 17326324.72307788 11313128.819750464 1.0 1.2504532535178543 0.816476602292985 23.72401119993228 -6.750224535546628 1.6490957551781367 1.1472292077239132 0.8156033155843334 0.6499136258815432 0.10524299158227213 0.29964853774858075 1.6033977537080897 0.05041348122970201 0.12235751952657183 1.777360255511984e-07 6.750224535546628 -0.3316258921395798 VLQGDLVMNVYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLQGDLVMNVYR 12 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 29324000.0 9133400.0 10723000.0 9467600.0 False True 11823366.34622978 10126255.623725446 7744593.945779495 1.0 0.8564612925957837 0.6550244421927331 23.49513752202473 -6.966340487983694 0.33425180114145264 1.0233560316034689 0.48149327558563226 0.9999381651478999 0.001112635357208693 0.07750901546504538 0.013272141379063903 0.0028964059124076355 0.017510850818455645 1.0805864365866713e-07 6.966340487983694 -0.5418627560178366 VLQHYQESDK(ub)GEELGPGNVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLQHYQESDKGEELGPGNVQK 21 1 Q9Y6C9 Q9Y6C9 MTCH2 Mitochondrial carrier homolog 2 1 28351400.0 2372400.0 12730000.0 13249000.0 True False 3599104.245672127 10458232.04005602 10630329.342757002 1.0 2.905787475489741 2.9536041795788006 21.779206458898887 -10.581507640921593 0.6905311524399504 9.507000394036766e-16 2.945530234090616 0.9999328273882276 0.007457247623569193 2.053618983567045 0.34910238017435785 3.604321668780671 0.007513695357434282 2.6211529220001437e-11 10.581507640921593 2.945530234090615 VLQHYQESDK(ub)GEELGPGNVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLQHYQESDKGEELGPGNVQK 21 1 Q9Y6C9 Q9Y6C9 MTCH2 Mitochondrial carrier homolog 2 1 20016200.0 2372400.0 10313000.0 7330800.0 True False 3071118.5669953786 9739072.484144405 5996669.620359997 1.0 3.171180881392216 1.9526011417484361 21.550332780991337 -10.32495285514271 5.91258036406346 0.9998406396715627 2.5618910115703293 0.6865640645653797 0.4974830955034839 0.0010451525326154508 0.00011932763900460723 0.48173278975427253 0.16056197865872396 4.73202624705931e-11 10.32495285514271 1.5620503718987666 VLQIAVILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLQIAVILR 9 0 Q68CP9-3;Q68CP9;F8WCU9 Q68CP9-3 ARID2 AT-rich interactive domain-containing protein 2 0 78138000.0 21838000.0 29567000.0 26733000.0 False True 33129842.571652226 24290537.841974624 21449210.83250984 1.0 0.7331920696405296 0.6474286977404174 24.981628012163025 -13.999999999999998 0.15876781577992377 2.3106276865934174 0.5619622447065844 0.9995396622624089 0.0032210842039011507 12.001709721107535 0.1258755846143139 4.844442039842606 0.07777637039266455 1.0000000000000041e-14 13.999999999999998 -1.748665441886833 VLQIAVILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLQIAVILR 9 0 Q68CP9-3;Q68CP9;F8WCU9 Q68CP9-3 ARID2 AT-rich interactive domain-containing protein 2 0 67521000.0 21838000.0 22538000.0 23145000.0 False True 28269721.49133575 21283740.48750574 18932847.487754688 1.0 0.7528811521552801 0.6697217549015233 24.752754334255474 -13.999999999999597 0.15210992706948442 2.198972273365588 0.5804127090163157 0.9995593489870508 0.002944381126727538 11.966271677236003 0.12293457517451181 4.238164928410406 0.0806674389197158 1.0000000000009285e-14 13.999999999999597 -1.618559564349272 VLQICAGHVPGVSALNLLSLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLQICAGHVPGVSALNLLSLLR 22 0 B1AHQ6;Q9NSP4;Q9NSP4-3 B1AHQ6 CENPM Centromere protein M 0 1822680000.0 642700000.0 686630000.0 493350000.0 False True 975022887.663746 564095511.8353238 395839156.25701326 1.0 0.5785459182265495 0.4059793480391872 29.860860844147226 -13.999999999999998 0.12277071585801659 3.005322749509057 0.14056101581449026 0.9996794618471705 0.004466983360694296 11.95397520714155 0.10818222306255842 5.828375649174002 0.2355991424163071 1.0000000000000041e-14 13.999999999999998 -2.864761733694567 VLQICAGHVPGVSALNLLSLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLQICAGHVPGVSALNLLSLLR 22 0 B1AHQ6;Q9NSP4;Q9NSP4-3 B1AHQ6 CENPM Centromere protein M 0 1708100000.0 642700000.0 616010000.0 449390000.0 False True 831987819.5110123 581728501.9836909 367605631.13078755 1.0 0.6992031473797208 0.4418401598076784 29.631987166239675 -7.174865451266623 0.19106722467971882 1.18575706699728 1.9094793756964986e-10 0.9999915852525783 0.0006616446862308682 0.08705939774564106 0.008371050039987745 0.013478744620883727 0.03525253844468948 6.685510092139309e-08 7.174865451266623 -1.185757066806332 down VLQK(ub)DAEQESQMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLQKDAEQESQMR 13 1 A0A096LNT6;A0A3B3IUG4;B4DLW3;H7BYE5;A0A3B3ISA8;H7C384;B7Z1T1;A0A3B3ISE9;A0A3B3ITX9;O00258-2;O00258;C9JLV3 A0A096LNT6 WRB Tail-anchored protein insertion receptor WRB 1 8505550.0 796530.0 844320.0 6864700.0 True False 771244.5911484782 1181461.3790706343 5066629.133414349 1.0 1.5318893547263557 6.569419340587547 19.556828940902264 -6.927097910025634 0.7702373201071274 0.9145879871307115 7.531114830721789 0.9959365508396976 0.15996817735511576 0.09417297525893982 0.08526850238589005 0.1432974686371934 0.4632959944057279 1.1827748736051832e-07 6.927097910025634 6.616526843591077 up VLQLINDNTATALSYGVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLQLINDNTATALSYGVFR 19 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 22236000.0 8362400.0 11253000.0 2620600.0 False True 10963187.38159679 9574096.263850443 2349445.450570236 1.0 0.8732949579902167 0.21430313728962633 23.386163965347357 -6.938930393631601 0.6694444110698853 1.007551485804257 0.04205199368696434 0.9980203600429816 0.015324455106940381 0.08825812557585641 0.05685823269689483 0.014798932480791093 0.05699065881353999 1.1509848477822703e-07 6.938930393631601 -0.9654994921172926 down VLQLINDNTATALSYGVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLQLINDNTATALSYGVFR 19 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 107915000.0 59951000.0 25280000.0 22684000.0 False True 58047888.32051834 35374435.833458394 16742379.894586932 1.0 0.6094009077149237 0.28842358230400883 25.790740249563726 -7.7405977804225525 0.26168371762360115 1.1395952859881902 1.97571093129385e-12 0.9996993145109102 0.005045377709086406 0.12527331189823887 0.03682625709592927 0.04216471854628993 0.08164169392892563 1.817197872033674e-08 7.7405977804225525 -1.1395952859862144 down VLQLINDNTATALSYGVFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLQLINDNTATALSYGVFR 19 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 53669000.0 11504000.0 29346000.0 12819000.0 False True 17452409.055054832 24108977.018655475 10285319.031232696 1.0 1.3814125570058573 0.5893352028815589 24.05692285777518 -6.775766257055235 1.5523727043197515 1.217152612497137 0.5838744909861205 0.7521251055793339 0.16103005547751478 0.25720686073668386 1.2239518234431477 0.08172738732335239 0.19353541800038007 1.6758445947270264e-07 6.775766257055235 -0.6332781215110165 VLQLINDNTATALSYGVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLQLINDNTATALSYGVFR 19 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 28887600.0 8362400.0 4355200.0 16170000.0 False True 11454205.265362764 4162772.8632795466 12350979.031603547 1.0 0.3634274719929867 1.0782920984446303 23.44937402687025 -6.671805260284048 1.9307491095789568 0.5943171398947099 1.07544116322522 0.2871690075286436 0.2702889590944399 0.4569832278730291 3.2859003938898823 0.11262633825496747 0.30022737387841547 2.1290935276567702e-07 6.671805260284048 0.4811240233305102 VLQLINDNTATALSYGVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLQLINDNTATALSYGVFR 19 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 96337000.0 59951000.0 15350000.0 21036000.0 False True 49851912.779616475 15267306.503263554 25434530.34052537 1.0 0.3062531736897781 0.5102016938239746 25.571145524998002 -10.158619983655774 5.854777316416561 1.000007015557588 0.4082274337570384 0.9182040276061546 0.08326163468747604 7.6247279779294045e-06 1.0957004923502884e-06 0.08061868663292007 0.026872577043541925 6.940328329856971e-11 10.158619983655774 -0.5917795818005496 VLQLINDNTATALSYGVFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLQLINDNTATALSYGVFR 19 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 38983000.0 11504000.0 14157000.0 13322000.0 False True 14892154.777741855 13369150.504996823 10897532.695263254 1.0 0.8977311010075353 0.7317633249119159 23.82804917986763 -6.963916066414941 0.37619354520921916 1.011899710830036 0.6117609720381414 0.9998890229630961 0.0011643880670514938 0.07833074566645169 0.01616895792946291 0.002169145830590113 0.014050304073843627 1.0866356111105926e-07 6.963916066414941 -0.40013873879189465 VLQLMLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLQLMLR 7 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 24096100.0 9558500.0 8760400.0 5777200.0 False True 12531286.06464568 7453382.46777174 5179430.762815535 1.0 0.5947819265573907 0.4133199686046735 23.57903114781585 -13.999999999999998 0.10862323974101515 2.960131280959928 0.07373858575448573 0.9997500593554716 0.003877262302690598 12.020927510524157 0.0997834360467615 5.1811148985502005 0.30173188542002416 1.0000000000000041e-14 13.999999999999998 -2.886392695205442 VLQLMLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLQLMLR 7 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 16635700.0 9093900.0 4049700.0 3492100.0 False True 8805219.122249192 5666766.328906508 2577414.2492455943 1.0 0.6435690299390299 0.2927143792177682 23.069927476009703 -7.439076426271571 0.29307014138731574 1.0897817156113936 1.5268624497999457e-11 0.999782374842761 0.004259688613769212 0.11999020837122752 0.02712867339105684 0.020030302486254894 0.060344669412253645 3.6385100072387293e-08 7.439076426271571 -1.089781715596125 down VLQLMLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLQLMLR 7 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 60479000.0 16536000.0 26125000.0 17818000.0 False True 25086320.94353154 21462789.634443324 14296264.490093177 1.0 0.8555574842064462 0.56988286653406 24.58039757076133 -6.960262871440898 0.4317137865400981 1.0111433118123276 0.40331084616772533 0.9997798221154637 0.0026519426850597724 0.07960735888501477 0.020785395949599994 0.0037314123528811418 0.023710546804021255 1.0958147164039626e-07 6.960262871440898 -0.6078324656446024 VLQLMLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLQLMLR 7 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 37971500.0 9558500.0 14658000.0 13755000.0 False True 13092535.758749893 14010361.092475995 10506352.293117298 1.0 1.0701029464909202 0.8024688636879056 23.642241209338742 -6.837094975204065 1.2956970115308408 1.0373199515272002 0.7941540898201682 0.9193606096414112 0.03217791912570451 0.1722211829672443 0.5628700642048314 0.019481575431371505 0.044855878467280424 1.4551408232355885e-07 6.837094975204065 -0.24316586170703203 VLQLMLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLQLMLR 7 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 17009400.0 9093900.0 4038600.0 3876900.0 False True 7561980.7780779945 4016843.2602006635 4687541.865239723 1.0 0.531189297894726 0.619882806212467 22.85033275144398 -10.083468083517632 5.29756866105117 1.0000059217473718 0.5755360520531697 0.9682919421435713 0.03620897314755041 2.5325085014517787e-06 4.38161084168203e-07 0.03505967682113341 0.011686395831748391 8.251481237299202e-11 10.083468083517632 -0.4244698696942021 VLQLMLR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VLQLMLR 7 0 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 55282600.0 22617000.0 6832300.0 25833300.0 False True 29278152.347721446 6452076.498925614 21131904.472042046 1.0 0.22037171001426745 0.721763594268838 24.8033211767513 -9.867830508606044 5.885287768384345 1.0000001148833055 0.4710676521517951 0.5973960925832144 0.20469237960157935 3.0856353658200557e-07 5.921366255277153e-08 0.19819258862115086 0.06606418144071935 1.355718403114036e-10 9.867830508606044 -0.5289324627315104 VLQLSDTAIVPIGYHVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLQLSDTAIVPIGYHVPR 18 0 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2;I3L167;E7EP81;I3L212 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 0 8248800.0 1344300.0 3900500.0 3004000.0 False True 1841324.038341527 3728163.01277137 2294517.069322015 1.0 2.0247185911553682 1.246123453310628 20.81231210550215 -10.170807802141853 4.595273371348189 0.9999220183648494 1.635421022152677 0.470353640478431 0.3178601342331341 0.00032025714184210805 5.778903316670775e-05 0.30781403706926336 0.10258891715578032 6.748266074373928e-11 10.170807802141853 0.6354990037878276 VLQQAFNYLNQGVVHSITWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLQQAFNYLNQGVVHSITWK 20 0 O15397;O15397-2;F5H244 O15397 IPO8 Importin-8 0 50707000.0 40990000.0 5128200.0 4588800.0 False True 39688794.88679161 7175917.0032097045 3386855.6189508266 1.0 0.18080460804310897 0.08533531009473831 25.242228421126132 -13.999999999999998 0.30333279409409025 8.617407969178872 0.06264627559310021 0.9996572535437843 0.007600291767234194 16.808765214529693 0.17501262393041275 80.51288734166955 0.034014867611419 1.0000000000000041e-14 13.999999999999998 -8.554761693585773 VLQQAFNYLNQGVVHSITWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLQQAFNYLNQGVVHSITWK 20 0 O15397;O15397-2;F5H244 O15397 IPO8 Importin-8 0 180902000.0 117050000.0 27516000.0 36336000.0 False True 177573407.50123146 22605554.81651073 29154173.673365418 1.0 0.12730259071226058 0.16418096652880435 27.40384030622262 -10.154574766797074 4.239164413053866 1.0002220709201668 0.1457417785498852 0.9986042103540241 0.015055534142837574 28097548.098557763 54639688.027778134 84687.59926547257 0.005762241302848663 7.005275718198856e-11 10.154574766797074 -0.8544802923702816 VLQQAFNYLNQGVVHSITWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLQQAFNYLNQGVVHSITWK 20 0 O15397;O15397-2;F5H244 O15397 IPO8 Importin-8 0 69032000.0 40990000.0 16435000.0 11607000.0 False True 34085001.16489261 16346461.392907938 14033970.035295598 1.0 0.47957931155198896 0.4117344742751695 25.02263369656041 -13.999999999999998 0.28720363882964334 5.414554640731149 0.39272005562473195 0.9996212082392579 0.005114441662811476 15.801644411251743 0.16989135538658273 41.147757453089014 0.025951235573536718 1.0000000000000041e-14 13.999999999999998 -5.021834585106417 VLQQAFNYLNQGVVHSITWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLQQAFNYLNQGVVHSITWK 20 0 O15397;O15397-2;F5H244 O15397 IPO8 Importin-8 0 166403000.0 117050000.0 30505000.0 18848000.0 False True 151523532.40044183 28807369.933949865 15417857.39681143 1.0 0.19011812539994524 0.10175223051206053 27.17496662831507 -13.999999999999998 0.3128478700507368 8.96039682686638 0.08277416972235768 0.9996782380951796 0.00725083821869494 17.47500313253987 0.1780757842455465 90.69650755229402 0.03026894386940624 1.0000000000000041e-14 13.999999999999998 -8.877622657144022 VLQQK(ub)LEAIEDDSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLQQKLEAIEDDSVK 15 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 82094000.0 18385000.0 32989000.0 30720000.0 True False 27891389.12353819 27101855.20576658 24648178.53494567 1.0 0.9716925566426772 0.8837200049725922 24.733316453426543 -6.950655470994598 0.5516094477096384 1.0012051894134937 0.8500631901839716 0.9992516515610558 0.0013543921601005663 0.08322378970680701 0.034882571964768995 0.0014670037283530232 0.007300299847222419 1.1203262941149054e-07 6.950655470994598 -0.1511419992295221 VLQQK(ub)LEAIEDDSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLQQKLEAIEDDSVK 15 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 98280800.0 18385000.0 29010000.0 50885800.0 True False 23799744.92252992 27395567.998160493 41625106.53239962 1.0 1.1510866224547895 1.748972800670456 24.504442775518992 -6.945122462164775 0.6100576754398696 0.9933872865048974 1.9378107630159163 0.9987606893143189 0.011384723969314309 0.08550564642027281 0.04453962047632162 0.011571690628032321 0.05041619693604053 1.1346908109470303e-07 6.945122462164775 0.9444234765110189 VLQQK(ub)LEAIEDDSVKETDSSSASAATPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLQQKLEAIEDDSVKETDSSSASAATPSK 29 2 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 8399650.0 947550.0 2669600.0 4782500.0 True False 1242247.2260872538 2271306.086019297 4287652.7769793775 1.0 1.828384912698339 3.4515293630273067 20.24452088970716 -6.960443876032087 0.42913202570239856 0.9349295254543024 4.4071406207430375 0.9997863098351738 0.014884381233720856 0.07954293512962891 0.020548228330953468 0.02114805024207209 0.1347985965875228 1.0953580995799347e-07 6.960443876032087 3.472211095288735 VLQQK(ub)LEAIEDDSVKETDSSSASAATPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLQQKLEAIEDDSVKETDSSSASAATPSK 29 2 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 18731400.0 3701100.0 4139300.0 10891000.0 True False 3583610.6063797134 5792144.076164332 8038320.377003456 1.0 1.6162872344034485 2.243078632118472 21.772982452599987 -6.970914586392937 0.23531909405709603 0.7614584259929766 3.115932449823999 0.9999886634421045 0.001708701774507721 0.07600705974988625 0.007960483502480246 0.015492396948668111 0.06162771726259357 1.069265153165849e-07 6.970914586392937 2.3544740238310222 VLQQK(ub)LEAIEDDSVKETDSSSASAATPSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLQQKLEAIEDDSVKETDSSSASAATPSK 29 2 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 99544400.0 14835000.0 33927000.0 50782400.0 True False 22505779.583774216 27872461.77713914 40745236.38128335 1.0 1.2384579558058983 1.8104343477467923 24.423792203703513 -6.956342549436967 0.4842380261820461 0.9868038063364678 2.0861071524341335 0.9996095714337366 0.006719513376784769 0.08103449053792457 0.026162877316667468 0.008135305563127927 0.04717764767085412 1.1057512794621462e-07 6.956342549436967 1.0993033460976656 VLQQK(ub)LEAIEDDSVKETDSSSASAATPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLQQKLEAIEDDSVKETDSSSASAATPSK 29 2 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 11063150.0 947550.0 2179500.0 7936100.0 True False 1297884.8415759231 2083202.4833573112 6061756.629110014 1.0 1.6050749778600053 4.670488809892936 20.307730951230052 -6.939512248490161 0.6640846738451279 0.9652861721779533 5.485408378598756 0.9980993272135287 0.07004984506996292 0.08798983411907095 0.055628062317985935 0.0679389034368962 0.2644060526053046 1.1494438249791116e-07 6.939512248490161 4.520122206420803 VLQQK(ub)LEAIEDDSVKETDSSSASAATPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLQQKLEAIEDDSVKETDSSSASAATPSK 29 2 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 16464000.0 3701100.0 5428900.0 7334000.0 True False 3077628.636530472 5399653.4381477265 8867505.491415352 1.0 1.7544850519180772 2.8812785877285143 21.553387728034263 -6.965329723175765 0.3523474302646103 0.894008261417292 3.779914905779293 0.9999197820493558 0.006923562860055573 0.07784923951726726 0.014466408034017246 0.015377130168336556 0.09670210746600949 1.0831042920369326e-07 6.965329723175765 2.8859066443620014 VLQQK(ub)LEAIEDDSVKETDSSSASAATPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLQQKLEAIEDDSVKETDSSSASAATPSK 29 2 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 128219700.0 14835000.0 32553000.0 80831700.0 True False 19204199.9415682 30741396.933613196 66121160.00328116 1.0 1.6007642613151671 3.44305725854059 24.194918525795963 -6.950956007593821 0.5482466392104064 0.9742528255002963 4.155857228177612 0.9992741944998914 0.02800270262540487 0.08310409156023281 0.03439094288648244 0.030462398249798257 0.15278394524301014 1.1195512840799945e-07 6.950956007593821 3.1816044026773156 VLQQQQK(ub)QATYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLQQQQKQATYR 12 1 Q9Y613 Q9Y613 FHOD1 FH1/FH2 domain-containing protein 1 1 8714710.0 450610.0 1576500.0 6687600.0 True False 683608.3140036742 1295161.2577492788 5365792.928720795 1.0 1.8945955325849324 7.849221284766228 19.38281041752888 -6.933680070310923 0.7159383784258408 0.9206361556880435 9.19472912061979 0.9972133969123231 0.16047185489827787 0.09077154472250377 0.06864533713211945 0.14954065243400738 0.5283131072527614 1.1649839166485526e-07 6.933680070310923 8.274092964931747 VLQQQQK(ub)QATYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLQQQQKQATYR 12 1 Q9Y613 Q9Y613 FHOD1 FH1/FH2 domain-containing protein 1 1 6106310.0 450610.0 1172300.0 4483400.0 True False 583323.5278510314 1107060.4744654794 3667467.2035687775 1.0 1.8978498579405825 6.287192318608777 19.15393673962133 -6.9403085144520835 0.6566865706827595 0.9509803147295824 7.4816809264461615 0.99820403847043 0.09789699815091295 0.08762615287329736 0.05397071652314216 0.09551964961056815 0.37727127589855586 1.1473382848676114e-07 6.9403085144520835 6.530700611716579 VLQQTLNYINQGVSHALTWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLQQTLNYINQGVSHALTWK 20 0 O95373 O95373 IPO7 Importin-7 0 70026900.0 32104000.0 9256900.0 28666000.0 False True 31084876.09284112 12953228.444095775 21157514.63843368 1.0 0.4167051657342433 0.6806369301663802 24.889709492383986 -10.407650454858407 6.031504686991914 1.0001207074668201 0.5486710479503234 0.7958724321521715 0.1077496916285314 0.00017494144201878674 1.7180857285574013e-05 0.10435579776981337 0.03477606343635715 3.911555936187047e-11 10.407650454858407 -0.45144965951649674 VLQQTLNYINQGVSHALTWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLQQTLNYINQGVSHALTWK 20 0 O95373 O95373 IPO7 Importin-7 0 1588963000.0 622484000.0 351129000.0 615350000.0 False True 944353737.6761781 288467286.566601 493725802.78251433 1.0 0.30546528812015705 0.522818709859138 29.81475212715854 -10.31785669569027 6.318601653401185 1.000028681383803 0.41414199898984905 0.9064286058076733 0.08873416285141057 3.5853882909373735e-05 3.870664740721266e-06 0.08592067562085119 0.028638827913597426 4.809980373660504e-11 10.31785669569027 -0.585886682393954 VLQQTLNYINQGVSHALTWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLQQTLNYINQGVSHALTWK 20 0 O95373 O95373 IPO7 Importin-7 0 5321600.0 1828400.0 1391500.0 2101700.0 False True 2504408.8906521187 1330018.9289248437 1605321.7458702007 1.0 0.5310709979864838 0.640998261850202 21.256038697232523 -9.866860551069758 6.555082758242981 1.000000015457567 0.586034629918338 0.9497700711333624 0.044877617547830755 1.0105953656065e-08 1.7779923792736449e-09 0.04345256763999522 0.014484188781670078 1.3587496615937558e-10 9.866860551069758 -0.413965385539229 VLQQTLNYINQGVSHALTWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLQQTLNYINQGVSHALTWK 20 0 O95373 O95373 IPO7 Importin-7 0 141761800.0 32104000.0 46252300.0 63405500.0 False True 26695898.44834623 46003129.67953727 76663296.89609165 1.0 1.7232283741470065 2.871725671433277 24.670114767818262 -6.964292549870224 0.36999735050113014 0.9116770573462479 3.7232539952956345 0.999897805406508 0.007790856806736448 0.0782019047715215 0.015711752275842254 0.0151381108935327 0.09754123228928027 1.0856940309702424e-07 6.964292549870224 2.8115769379493867 VLQQTLNYINQGVSHALTWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLQQTLNYINQGVSHALTWK 20 0 O95373 O95373 IPO7 Importin-7 0 1244569000.0 622484000.0 334408000.0 287677000.0 False True 805817808.994077 315797900.8317424 235322737.81528682 1.0 0.391897395797148 0.2920297059567922 29.585878449250988 -13.999999999999998 0.2542120218841986 5.320493228802493 0.25345321603099996 0.9995507641791122 0.006631317883427303 14.168963115457402 0.15954194229615923 31.33889390647711 0.045033768782636485 1.0000000000000041e-14 13.999999999999998 -5.067040012771494 VLQSALAAIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLQSALAAIR 10 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 23305500.0 5780500.0 10917000.0 6608000.0 False True 7578291.478441629 9288226.154132709 5924267.548411869 1.0 1.2256359075862182 0.7817418431667548 22.853441199592435 -6.7685337416626075 1.58022858796085 1.129660809145243 0.779391249160738 0.7248750838374434 0.09505799895251897 0.26879997500877323 1.3244923326220945 0.04742336075784614 0.11303236300713475 1.7039869262322708e-07 6.7685337416626075 -0.35026955998450493 VLQSALAAIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLQSALAAIR 10 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 15048600.0 6645000.0 3408100.0 4995500.0 False True 6434058.112289097 4768972.103006714 3687028.6882123537 1.0 0.7412074960743583 0.5730487079639679 22.617297535767527 -8.702597088538536 0.0943819303407077 1.6068141799925737 1.0746100862781832e-11 0.9999790831706048 0.0008031135381058431 0.259594119241344 0.025816291487952468 0.23024317731295282 0.19176792359490347 1.9833662165878846e-09 8.702597088538536 -1.6068141799818276 VLQSALAAIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLQSALAAIR 10 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 38976500.0 7625300.0 27387000.0 3964200.0 False True 11568137.58410203 22499575.87439233 3180674.132429415 1.0 1.94496095078548 0.2749512710499382 23.463653280216363 -6.75318878901215 1.6380404523733325 1.5534995012179236 0.2708041337205137 0.6626084063768637 0.3971568186536533 0.2945008908854545 1.5556387087099823 0.19145642765917506 0.4632596446398799 1.7652702859990587e-07 6.75318878901215 -1.2826953674974098 VLQSALAAIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLQSALAAIR 10 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 23643900.0 5780500.0 8203900.0 9659500.0 False True 7917707.062138799 7841424.571330592 7378125.043647141 1.0 0.9903655830899608 0.9318512273494113 22.916651261115327 -6.93557995818407 0.6994954345139007 1.000733115175304 0.9179330995622809 0.9975254018924407 0.001497958362288545 0.0898424915245961 0.06423823125769973 0.0014132542932945298 0.005141867679250511 1.1598986469423186e-07 6.93557995818407 -0.08280001561302319 VLQSALAAIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLQSALAAIR 10 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 20327500.0 7625300.0 7355600.0 5346600.0 False True 9871101.167134484 6946254.393907936 4373573.660748727 1.0 0.7036959986830312 0.44306846690118024 23.234779602308812 -7.1003041271350895 0.19554408054694225 1.1727091828189442 1.5120043861398232e-14 0.9999941018302855 0.0005525326289077593 0.07657836712211519 0.007083462136232193 0.010474728553568626 0.029877724321685013 7.93772178373973e-08 7.1003041271350895 -1.172709182818929 down VLQTLGVLLTTCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLQTLGVLLTTCR 13 0 D6REA1;Q9H173 D6REA1 SIL1 Nucleotide exchange factor SIL1 0 8685500.0 1338100.0 2434100.0 4913300.0 False True 1832831.7307928237 2326553.4135077004 3752879.7325898353 1.0 1.2693764377929602 2.047585530924031 20.805642909869658 -6.952295976004797 0.5330461306913411 0.9879886939017658 2.3644852950296325 0.9993693402062828 0.011154493823269617 0.08257676903970337 0.032247172252803664 0.012389328641434766 0.06437994754911702 1.1161023536873459e-07 6.952295976004797 1.3764966011278665 up VLQVIIQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLQVIIQLR 9 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 71994000.0 18916000.0 25544000.0 27534000.0 False True 28696954.944838118 20985473.623817086 22091892.831419073 1.0 0.7312787598599154 0.7698340424579739 24.77439432379369 -10.879494538985274 11.023434420708428 1.0117108472639813 0.7505564011589447 0.9823976086407712 0.015740128209008514 0.004358262826747181 4.764336226171929e-05 0.014661948151159829 0.0050801045350549676 1.3197919072615778e-11 10.879494538985274 -0.2611544461050366 VLQVIIQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLQVIIQLR 9 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7;H0Y659 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 58431000.0 18916000.0 15682000.0 23833000.0 False True 24487134.890104778 14809282.914414084 19495638.54723085 1.0 0.6047781000462613 0.7961584168472489 24.54552064588614 -10.088087629694005 5.010180907540897 1.000008083451757 0.7004682584455375 0.7655940420804935 0.07813068716665927 7.054799109262241e-06 1.2841190750163191e-06 0.0756517533995866 0.02521657085141324 8.164176222134565e-11 10.088087629694005 -0.29953982500621956 VLRPPGGGSNFSLGFDEPTEQPVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLRPPGGGSNFSLGFDEPTEQPVR 24 1 Q9UK76;J3KT51;Q9UK76-2 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 0 16101400.0 3128300.0 6540100.0 6433000.0 False True 4101231.594500296 5564342.573110128 5767374.869693326 1.0 1.3567491727538252 1.406254374278036 21.967625783558212 -12.220621364705591 0.31057879877067146 3.926646105493896e-11 1.417956762030221 0.9995338849060393 0.003907163627659582 5.9694708089270065 0.17037574991413088 3.831706047046467 0.01710726842357457 6.016980933292818e-13 12.220621364705591 1.4179567619909546 VLRPPGGGSNFSLGFDEPTEQPVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLRPPGGGSNFSLGFDEPTEQPVR 24 1 Q9UK76;J3KT51;Q9UK76-2 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 0 17396600.0 4430800.0 2719800.0 10246000.0 False True 4290146.679297296 3805830.3235696326 7562265.226588683 1.0 0.887109604418702 1.7627055184573184 22.03259554336071 -6.874495163546212 1.1099811565951065 0.9340336330056936 1.8185772382939709 0.968970114224599 0.06850448077199113 0.13262092151444924 0.30267025407186043 0.0477523155211131 0.11403060145638572 1.3350724573089334e-07 6.874495163546212 0.8845436052882772 VLRPPGGGSNFSLGFDEPTEQPVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLRPPGGGSNFSLGFDEPTEQPVR 24 1 Q9UK76;J3KT51;Q9UK76-2 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 0 14509700.0 3128300.0 5039600.0 6341800.0 False True 4284917.049128763 4816933.808271398 4843997.45347083 1.0 1.1241603403386322 1.130476365804034 22.030835845081103 -12.974186732745798 0.43645138637574205 0.05061602099266812 1.1305674523877736 0.9998643301826802 0.0006997002320951461 13.103767709380417 0.22167062596154155 11.558463801806077 0.0014721203346890993 1.0612391601693645e-13 12.974186732745798 1.0799514313951055 VLRPPGGGSNFSLGFDEPTEQPVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLRPPGGGSNFSLGFDEPTEQPVR 24 1 Q9UK76;J3KT51;Q9UK76-2 Q9UK76 HN1 Hematological and neurological expressed 1 protein;Hematological and neurological expressed 1 protein, N-terminally processed 0 10031900.0 4430800.0 2721000.0 2880100.0 False True 3684406.517721544 2706341.4329237873 3482315.593922188 1.0 0.7345393131584739 0.9451496671642167 21.813000818794986 -9.907522550665316 5.727791045676947 1.0000000885237548 0.8398444904904763 0.4353521795863622 0.08598131697760901 9.716435546119321e-08 1.8626086084865335e-08 0.08325109808426319 0.02775035072815871 1.237306941319936e-10 9.907522550665316 -0.1601555980332785 VLSAMIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLSAMIR 7 0 H0Y8X4;O43598 H0Y8X4 DNPH1 2-deoxynucleoside 5-phosphate N-hydrolase 1 0 8789600.0 1913400.0 4039000.0 2837200.0 False True 2476934.0187527207 3814226.0994336554 2320858.7121303827 1.0 1.53989814446262 0.9369885085994616 21.24012400751439 -6.6706512156257585 1.935168771640754 1.344426688039822 0.9394251475593876 0.281867279745884 0.2293035553443581 0.459637977362343 3.3191373653079017 0.09537441822492625 0.25459067336699 2.1347586617449058e-07 6.6706512156257585 -0.40500154048043435 VLSAPPHFHFGQTNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLSAPPHFHFGQTNR 15 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 357060000.0 139200000.0 83350000.0 134510000.0 False True 182492548.01471746 70914504.89575538 120592195.51102898 1.0 0.3885884967206241 0.6608061360472844 27.44326231261641 -10.416431457394287 6.048548859887874 1.0001403548496581 0.524697316383983 0.802561595590137 0.11113238588921796 0.00021040087195299404 2.0299594573089e-05 0.10763483037097187 0.03586782331443637 3.833262341589185e-11 10.416431457394287 -0.47544303846567515 VLSAPPHFHFGQTNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLSAPPHFHFGQTNR 15 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 295964000.0 62029000.0 37875000.0 196060000.0 False True 60059923.34795802 52998685.01551569 144706004.32607648 1.0 0.8824301141456184 2.4093604563515703 25.83989929785466 -6.888314358852332 1.032335661878551 0.9146097783202887 2.536418226328681 0.9797960521508469 0.09861042563682197 0.1205201164008841 0.22993846607003518 0.07294043964477007 0.18076696441308032 1.2932593922707857e-07 6.888314358852332 1.6218084480083923 up VLSAPPHFHFGQTNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLSAPPHFHFGQTNR 15 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 164514000.0 57200000.0 75574000.0 31740000.0 False True 86776581.88014045 62087229.23764286 25466575.087863825 1.0 0.7154836926326553 0.2934728994400742 26.370802423888996 -7.063118085454322 0.36957160551118035 1.0349264205388093 7.342419769874345e-15 0.999897199868254 0.0029428848863794514 0.07365933996657766 0.016134336474093725 0.00599111042383029 0.03428920441160343 8.647327644066332e-08 7.063118085454322 -1.034926420538802 down VLSAPPHFHFGQTNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLSAPPHFHFGQTNR 15 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 384340000.0 139200000.0 144120000.0 101020000.0 False True 190666001.73855552 137752301.8588924 77161156.57220717 1.0 0.7224796272162917 0.40469279194311664 27.506472374139303 -6.969355507516401 0.2731403301159001 1.0760519124566725 0.04152654275564475 0.9999769100440159 0.0011686990117677502 0.07651238766443166 0.009776133069239372 0.0061117924402385344 0.029430197803684385 1.0731106190468263e-07 6.969355507516401 -1.0345253697010277 down VLSAPPHFHFGQTNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLSAPPHFHFGQTNR 15 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 164704000.0 62029000.0 56666000.0 46009000.0 False True 51579861.850625165 56360729.01067972 55629269.17841948 1.0 1.0926886383274912 1.0785075256603316 25.620304573288937 -10.104292971430734 4.4062901500451686 0.9999903234873114 1.0855980819994318 0.9798300418561818 0.005789415021920547 5.50400255176105e-07 1.118899659406595e-07 0.0056062106581491085 0.0018685256610699835 7.86515034219659e-11 10.104292971430734 0.08560775851212032 VLSAPPHFHFGQTNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLSAPPHFHFGQTNR 15 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 208838000.0 57200000.0 67973000.0 83665000.0 False True 74046527.5805662 64190242.796930864 68438828.47539413 1.0 0.8668906550288774 0.9242678990034932 26.141928745981446 -10.138020600024849 4.527953645609358 1.0000114059389753 0.8955792770634117 0.8153631623195051 0.02342416179240396 32733241.30335293 0.14442252247800197 4455.3693276765525 0.008018713623302056 7.277452843503579e-11 10.138020600024849 -0.10443212887556363 VLSEK(ub)CEAVVAELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLSEKCEAVVAELK 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 32545000.0 9693500.0 14390000.0 8461500.0 True False 12708272.371987531 12243068.091780668 7585985.148439308 1.0 0.9633935859580489 0.5969328423555723 23.599264580488633 -6.926178559169083 0.7775226717294006 1.0064326202726823 0.5285340127418569 0.9957323126668988 0.011889224601681106 0.0946713517359609 0.08776197020677755 0.010594807577872404 0.03388182492478106 1.185281322305084e-07 6.926178559169083 -0.47789860753082547 VLSEK(ub)CEAVVAELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLSEKCEAVVAELK 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 24666800.0 11970000.0 9448900.0 3247900.0 True False 11590018.902046723 13221895.045362547 2397177.55508856 1.0 1.1408001278606754 0.20683120324033585 23.466379583434854 -6.868502524943511 1.1420658157336725 1.0789453738062988 0.1536858408577913 0.9631615658068705 0.07890928411278494 0.13829462537907983 0.33807462719963094 0.053671691201444036 0.12674282022679495 1.353622220828017e-07 6.868502524943511 -0.9252595329485076 down VLSEK(ub)CEAVVAELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLSEKCEAVVAELK 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 57446400.0 21314000.0 26873000.0 9259400.0 True False 32334896.262120873 22077303.19029266 7429275.53146081 1.0 0.6827701877044646 0.2297603020351709 24.946588646103006 -7.262686758467966 0.40691007885329217 1.0289281604861187 7.867984835734662e-12 0.9995287580486311 0.006861354418139904 0.09700048180196083 0.030491497128881447 0.010796482780172601 0.04941024382564186 5.461516392811437e-08 7.262686758467966 -1.0289281604782508 down VLSEK(ub)CEAVVAELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLSEKCEAVVAELK 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 34736300.0 9693500.0 16604000.0 8438800.0 True False 13277448.906987706 15870380.37791456 6445729.242541493 1.0 1.1952883787458775 0.4854644358035684 23.662474642011524 -6.833358036983309 1.3128943993864604 1.1041296448034024 0.465026970202605 0.9124159672452051 0.08860464890222025 0.17670315928178426 0.5944932737002271 0.05297032730130239 0.12189941884063607 1.467715778262666e-07 6.833358036983309 -0.6391026746007974 down VLSEK(ub)CEAVVAELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLSEKCEAVVAELK 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 23887000.0 11970000.0 7031000.0 4886000.0 True False 9953585.360911543 6993122.607455779 5907640.009688491 1.0 0.7025732290314486 0.5935187970445529 23.24678485886913 -13.99999999999999 0.13948153865999244 2.42011889649483 0.45771150738461275 0.9996050080652603 0.003414066557815881 11.933527392571584 0.11697436244634515 4.613925206216787 0.12136838532113049 1.0000000000000246e-14 13.99999999999999 -1.9624073891102172 VLSEK(ub)CEAVVAELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLSEKCEAVVAELK 14 1 Q9UPN4-3;Q9UPN4-2;I3L2J8;Q9UPN4;I3L2X7 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 57394200.0 21314000.0 29707000.0 6373200.0 True False 27591393.161751542 28053779.335448258 5213342.994554254 1.0 1.0167583481916274 0.18894816089900202 24.717714968195455 -6.902280204035526 0.9467344808802051 1.032297282469855 0.09791522979178814 0.987667138904232 0.042904827676596785 0.10974647049533638 0.1681026343925599 0.03383777928459381 0.08909189936949155 1.252332917000817e-07 6.902280204035526 -0.934382052678067 down VLSEK(ub)DVDPVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLSEKDVDPVR 11 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 10505400.0 1930900.0 2029300.0 6545200.0 True False 2531428.5988622 1726536.3501494462 5867965.489991735 1.0 0.6820403115163791 2.318045033002 21.271520361681656 -6.85628895172209 1.2042314950845605 0.8288989243661983 2.391873551446478 0.9489750119299776 0.15998968569176542 0.15068075996347144 0.41733010637992984 0.10376052474514876 0.24130157869374075 1.392230193958442e-07 6.85628895172209 1.5629746270802798 up VLSEK(ub)DVDPVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLSEKDVDPVR 11 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 23017000.0 2737800.0 2408200.0 17871000.0 True False 2650890.037595951 3369806.8185971 13190048.981491944 1.0 1.2711982657919387 4.9757058174520825 21.338045395883437 -6.921610344446933 0.8126981186693697 0.9229097073340435 5.595785092854399 0.994616596543887 0.13306880481962124 0.09723348230400565 0.10077349405642703 0.11564101624854463 0.35191469225727245 1.1978147467733832e-07 6.921610344446933 4.6728753855203555 up VLSEK(ub)DVDPVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLSEKDVDPVR 11 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 88667800.0 6325800.0 23326000.0 59016000.0 True False 9596701.077926448 19163293.05313016 47351461.73236834 1.0 1.9968625569892982 4.934139486878707 23.194107125528042 -6.951854346594096 0.5381011697170349 0.9562073024702928 6.1099977431612205 0.9993388852096877 0.04293816894173521 0.0827495702389805 0.03294605653237483 0.04735123661651811 0.2431758077382956 1.1172378834821559e-07 6.951854346594096 5.153790440690928 VLSEK(ub)DVDPVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLSEKDVDPVR 11 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 12453040.0 1930900.0 532840.0 9989300.0 True False 2644805.9106104686 509297.366933751 7630033.076091346 1.0 0.19256511976570562 2.8849122899646717 21.334730423204547 -6.826301640442545 1.3443227046774349 0.5673361173210433 2.952058613285094 0.8982840990322362 0.35978559629030854 0.18541530728411526 0.6566167696811308 0.2102100116777324 0.4838996502544929 1.4917579450435598e-07 6.826301640442545 2.3847224959640507 VLSEK(ub)DVDPVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLSEKDVDPVR 11 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 21613100.0 2737800.0 5520300.0 13355000.0 True False 2276602.005104732 5490561.048206239 16147468.753456773 1.0 2.4117351367937734 7.092793873171491 21.118450671317714 -6.949181421411572 0.567758672762673 0.9410861134612549 8.790158446009332 0.9991354742031395 0.07656500470000305 0.08381610527594006 0.0373355309046646 0.08132484601639091 0.3898125136466046 1.124135281577907e-07 6.949181421411572 7.849072332548078 VLSEK(ub)DVDPVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLSEKDVDPVR 11 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 92378800.0 6325800.0 12305000.0 73748000.0 True False 8188872.800159894 11620215.933035677 60326620.71838118 1.0 1.4190250864329927 7.366901671400154 22.96523344762049 -6.921113373003374 0.8164257851254751 0.8739560757112655 8.351054199451667 0.9944846482546124 0.21593839637073425 0.09752117733341643 0.10225186246773854 0.18715812911082866 0.5667368887534827 1.1991862135397195e-07 6.921113373003374 7.477098123740402 up VLSEPNPRPVFGICLGHQLLALAIGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLSEPNPRPVFGICLGHQLLALAIGAK 27 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 853961000.0 170460000.0 241036000.0 442465000.0 False True 258600282.2952578 198021242.57713634 355011598.8107013 1.0 0.7657425615299401 1.3728198424987237 27.946148609133942 -6.8021068152300215 1.4474945160776804 0.8710934945606367 1.3816231236071905 0.838195604747476 0.10055460546107158 0.21776650208350168 0.9005945005004082 0.05464705431442693 0.12691796097913247 1.577223302095788e-07 6.8021068152300215 0.5105296290465539 VLSEPNPRPVFGICLGHQLLALAIGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLSEPNPRPVFGICLGHQLLALAIGAK 27 1 F8VPD4;P27708 F8VPD4 CAD CAD protein;Glutamine-dependent carbamoyl-phosphate synthase;Aspartate carbamoyltransferase;Dihydroorotase 0 502125000.0 170460000.0 138171000.0 193494000.0 False True 220663830.26893914 130481662.38792963 158280077.41609874 1.0 0.5913142277504296 0.7172905374804346 27.71727493122639 -10.703918574471489 10.054637757615453 1.00036450618833 0.6543023826154329 0.9094240883085254 0.051429613086220634 0.0004206427898851337 1.2386739588596552e-05 0.049845464533639326 0.01659883624873529 1.9773403353337908e-11 10.703918574471489 -0.346062123572897 VLSGEFQIVNPHLLK(ub)DLTER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLSGEFQIVNPHLLKDLTER 20 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 21235900.0 6751200.0 2579700.0 11905000.0 True False 6536886.851420045 3609787.6629577787 8786723.357655516 1.0 0.5522181651612348 1.3441755314682748 22.640172294752485 -6.753288314196594 1.6374841392148476 0.7377486090176782 1.3461722894511845 0.6630864823197864 0.18820045842936406 0.2943381787721279 1.5537192148035535 0.09075133720845911 0.21958103227148135 1.764865793819721e-07 6.753288314196594 0.6084236804335063 VLSGEFQIVNPHLLK(ub)DLTER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLSGEFQIVNPHLLKDLTER 20 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 125653700.0 29532200.0 41188000.0 54933500.0 True False 44802506.49301902 33837679.596687146 44075869.64679167 1.0 0.7552630922995262 0.9837813349496288 25.41707611086706 -10.497847842831922 8.00838498922642 1.0000124196335374 0.8695222136738638 0.30298069165064256 0.09329218190171065 2.068910865690755e-05 1.2972904118273177e-06 0.09033835972899225 0.030109922236389863 3.177987298816267e-11 10.497847842831922 -0.13049020595967353 VLSGEFQIVNPHLLK(ub)DLTER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLSGEFQIVNPHLLKDLTER 20 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 18251400.0 6751200.0 5708700.0 5791500.0 True False 5613921.928871019 5677946.100011776 7002475.873129527 1.0 1.0114045353590504 1.24734115683325 22.42057757018676 -6.916968444735712 0.8469159610086401 0.9942039450369019 1.282854803580594 0.9932962982606085 0.009334268839097958 0.09998851087112086 0.11510318302544274 0.007915885881294379 0.023065847486739743 1.2106860972098978e-07 6.916968444735712 0.2886508585436921 VLSGEFQIVNPHLLK(ub)DLTER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLSGEFQIVNPHLLKDLTER 20 1 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 120582800.0 29532200.0 54337600.0 36713000.0 True False 38230015.06669232 51313664.79341081 30031610.707191106 1.0 1.342235013611531 0.7855505851828966 25.18820243295951 -6.740364207373364 1.6851700964410574 1.2035462660865446 0.7851880317406065 0.6065914188713148 0.1437925010992814 0.3171918089374014 1.7687549054858218 0.0674960815737255 0.16557549716646103 1.8181754635641308e-07 6.740364207373364 -0.4183582343459381 VLSGTIHAGQPVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLSGTIHAGQPVK 13 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 26353900.0 7317700.0 9436500.0 9599700.0 False True 9593575.56470761 8028610.983188908 8606415.130824657 1.0 0.8368736900060681 0.8971019275113158 23.193637183114507 -10.642463934267816 8.952120859215698 1.000083788685015 0.8669878092440944 0.8667219858337132 0.02458807499916887 4.114431667492207e-05 1.6432653560190304e-06 0.023822227595382117 0.00793576708225667 2.277907401495695e-11 10.642463934267816 -0.13309597944092055 VLSGTIHAGQPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLSGTIHAGQPVK 13 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 14724300.0 4399200.0 1717500.0 8607600.0 False True 4259549.804000332 2403306.70664418 6353011.33753511 1.0 0.56421613016172 1.4914748341640978 22.02226952797767 -6.77889516124512 1.5400327983295952 0.7528936680239156 1.4985850422167868 0.7635002240299481 0.18420507856146454 0.2522995807166039 1.181817842396596 0.09421270728851404 0.22252183263917466 1.6638142469111757e-07 6.77889516124512 0.7456913741928712 VLSGTIHAGQPVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLSGTIHAGQPVK 13 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 33846800.0 7252700.0 18946000.0 7648100.0 False True 11002876.143393282 15564938.274226356 6136449.682718687 1.0 1.4146245101170554 0.5577132381339529 23.39137735663769 -6.775136868950634 1.5548214067241386 1.2362534399987433 0.5519323488551353 0.7498084544808892 0.17501366550791664 0.25820282359173813 1.232509623800199 0.08868914985283949 0.21013553188449763 1.6782750223595363e-07 6.775136868950634 -0.684321091143608 VLSGTIHAGQPVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLSGTIHAGQPVK 13 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 19079200.0 7317700.0 3999400.0 7762100.0 False True 10023251.443406822 3822693.283752799 5928851.84546752 1.0 0.38138255887687245 0.5915098387926254 23.2568472446374 -10.236509861827352 5.035222740340085 1.0000734922974643 0.4864461988344363 0.8884459690855286 0.08578410280657656 7.078349040804434e-05 1.0732898187866178e-05 0.08307192454337288 0.02768670012810345 5.800830000243488e-11 10.236509861827352 -0.513627293463028 VLSGTIHAGQPVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLSGTIHAGQPVK 13 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 11024000.0 4399200.0 4090700.0 2534100.0 False True 3658129.717604184 4068662.587159629 3063968.5936454386 1.0 1.1122247982568303 0.8375778964044285 21.802674803411946 -6.795768921200403 1.4732224710515271 1.0622550464862652 0.8341750070540931 0.81947752261451 0.04790372553442917 0.22685244672666344 0.9724281542218626 0.025586547851370562 0.059662214108238056 1.6004093456736776e-07 6.795768921200403 -0.22808003943217214 VLSGTIHAGQPVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLSGTIHAGQPVK 13 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 22656300.0 7252700.0 8843600.0 6560000.0 False True 9388763.122090444 8351445.885850821 5366147.311284115 1.0 0.8895150274055843 0.5715499732502913 23.16250367873014 -6.952380905645163 0.5320638667649435 1.004941648506997 0.4416379256102393 0.9993751237933123 0.0045400903083252855 0.0825435505249436 0.03211297463851055 0.005049867431276666 0.026301198357478166 1.115884112591526e-07 6.952380905645163 -0.5633037228967578 VLSIGDGIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLSIGDGIAR 10 0 P25705;P25705-2;P25705-3;K7EK77;K7ERX7;K7EJP1;K7EQH4 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 19298800.0 8152500.0 4060100.0 7086200.0 False True 7893703.349952885 5681319.103141789 5230111.638556777 1.0 0.7197279719380003 0.6625675436090455 22.91227087223982 -13.999999999999998 0.22349365942198754 2.7176523391983642 0.6329973786045677 0.9995016314299605 0.0032917515559859056 13.097093810291543 0.14973748035160347 9.947070706864674 0.03092088191675933 1.0000000000000041e-14 13.999999999999998 -2.0846549605937965 VLSILISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLSILISR 8 0 H7BXH2;E9PKF6;Q5H9R7-3;Q5H9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7;Q5H9R7-5;E9PQP7;E9PK08;E9PNN8 H7BXH2 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 0 6344200.0 1817200.0 2631400.0 1895600.0 False True 2382366.7977898335 2238805.377116866 1699461.4958791689 1.0 0.9397400010753373 0.713350059048754 21.18396412216234 -6.9463169538929295 0.5979175842194991 1.0025620788518828 0.6389804580500517 0.9988795989320954 0.0041305468140024676 0.08499935622434082 0.04234982904648572 0.004248101857263483 0.019012418080267168 1.1315742238797392e-07 6.9463169538929295 -0.3635816208018311 VLSILISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLSILISR 8 0 H7BXH2;E9PKF6;Q5H9R7-3;Q5H9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7;Q5H9R7-5;E9PQP7;E9PK08;E9PNN8 H7BXH2 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 0 9471900.0 4196800.0 2467000.0 2808100.0 False True 4063574.881212173 3452085.965235048 2072574.3688057507 1.0 0.8495194665159667 0.5100372035441605 21.954318048981612 -6.957622886630359 0.46773259165347375 1.009167088921815 0.33652547991369336 0.9996716218683237 0.0037135223040221516 0.08056145225043734 0.024353536160326258 0.004674144678204145 0.028024147820644458 1.1024962307686274e-07 6.957622886630359 -0.6726416090081215 VLSILISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLSILISR 8 0 H7BXH2;E9PKF6;Q5H9R7-3;Q5H9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7;Q5H9R7-5;E9PQP7;E9PK08;E9PNN8 H7BXH2 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 0 20785900.0 6126000.0 9365200.0 5294700.0 False True 9293589.870589865 7693906.889358413 4248200.224250553 1.0 0.8278724364312926 0.4571107917828656 23.14780454893484 -6.958568752195925 0.45515997511136597 1.0113454606001095 0.2588124386510115 0.9997133657577831 0.0038351206210638176 0.08021646096777399 0.023051097398296222 0.004995282872171489 0.030646212973124098 1.1000976774873414e-07 6.958568752195925 -0.752533021949098 down VLSILISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLSILISR 8 0 H7BXH2;E9PKF6;Q5H9R7-3;Q5H9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7;Q5H9R7-5;E9PQP7;E9PK08;E9PNN8 H7BXH2 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 0 8771600.0 1817200.0 3217500.0 3736900.0 False True 2489067.9479835015 3075340.211150329 2854321.1838713204 1.0 1.235538874558162 1.1467429750898226 21.24717418368523 -10.08452717663961 4.222080315508601 0.9999750340505801 1.191140924802207 0.8606888408280424 0.03625077428715489 12597507.23434065 0.17546629902236138 3192.8619501953804 0.012409604233533496 8.231383261734861e-11 10.08452717663961 0.19116589075162682 VLSILISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLSILISR 8 0 H7BXH2;E9PKF6;Q5H9R7-3;Q5H9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7;Q5H9R7-5;E9PQP7;E9PK08;E9PNN8 H7BXH2 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 0 7844200.0 4196800.0 1783900.0 1863500.0 False True 3489825.149763875 1774289.776623576 2253149.2341495086 1.0 0.508417958058336 0.6456338462406802 21.73472332441589 -10.480845704276737 9.250294998457656 1.000006667812633 0.5770259021495237 0.9268441223713582 0.05601815177492261 7.703325439157453e-06 4.323369134427181e-07 0.05424019624491604 0.018079780742466228 3.3048693526027345e-11 10.480845704276737 -0.42298076566310927 VLSILISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLSILISR 8 0 H7BXH2;E9PKF6;Q5H9R7-3;Q5H9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7;Q5H9R7-5;E9PQP7;E9PK08;E9PNN8 H7BXH2 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 0 18608900.0 6126000.0 7644500.0 4838400.0 False True 7930227.761513085 7219076.854944426 3957860.846176387 1.0 0.9103240249895456 0.4990853939132296 22.91893087102729 -6.941750942593184 0.6430675787677478 1.0045127493810595 0.38223138575159177 0.9983843685512583 0.008766161073563454 0.08697683522100791 0.05103957590586508 0.008650981353537906 0.035130466993540006 1.1435339359074173e-07 6.941750942593184 -0.6222813636294677 down VLSILLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLSILLK 7 0 P19838;P19838-2;P19838-3 P19838 NFKB1 Nuclear factor NF-kappa-B p105 subunit;Nuclear factor NF-kappa-B p50 subunit 0 2146500.0 404380.0 479820.0 1262300.0 False True 553890.2139585998 458619.9658474438 964170.7378845472 1.0 0.82799795751893 1.7407253524009967 19.079240523863994 -6.857957536666681 1.195995680055475 0.9071373409364895 1.783234111727991 0.9511102578507272 0.08755922556446531 0.14892179597498728 0.4059408267682701 0.05714546260056328 0.13310424817559377 1.3868914261598053e-07 6.857957536666681 0.8760967707915016 VLSIQSHVIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLSIQSHVIR 10 0 O00764;O00764-2;A8MV33 O00764 PDXK Pyridoxal kinase 0 51849000.0 13646000.0 21261000.0 16942000.0 False True 17890038.14805196 18088941.674728885 15189004.359139513 1.0 1.0111181164081857 0.8490202331286498 24.092653127953884 -6.8904683524435715 1.0196255345541834 1.0086121892068571 0.8349506202848702 0.9811957435391755 0.010138269373546832 0.1187632541966393 0.219643221108631 0.007571570566983907 0.01890783808062627 1.2868610247093776e-07 6.8904683524435715 -0.17366156892198692 VLSIQSHVIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLSIQSHVIR 10 0 O00764;O00764-2;A8MV33 O00764 PDXK Pyridoxal kinase 0 25972300.0 10673000.0 4068300.0 11231000.0 False True 10334191.457104836 5692793.405904232 8289264.177222089 1.0 0.5508697443369305 0.8021202443973646 23.30092218152289 -10.138276586957963 5.374607756908493 1.0000075588489163 0.6764949943670266 0.6885202377552192 0.10257258712828796 9.290602085601777e-06 1.4894555924250904e-06 0.0993178000876755 0.03310516014371094 7.27316454608346e-11 10.138276586957963 -0.3235125644818897 VLSIQSHVIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLSIQSHVIR 10 0 O00764;O00764-2;A8MV33 O00764 PDXK Pyridoxal kinase 0 47990000.0 11894000.0 22804000.0 13292000.0 False True 18044067.567873996 18734448.0315348 10664830.37390943 1.0 1.0382608001806626 0.5910435844796602 24.10502125771209 -6.886090617708487 1.0452066873194896 1.0263293396445237 0.5553970444064764 0.9782767813168683 0.029832162859491106 0.1223734658162514 0.2408226524531605 0.021850884478400515 0.053762939224396976 1.299898319470557e-07 6.886090617708487 -0.47093229523804725 VLSIQSHVIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLSIQSHVIR 10 0 O00764;O00764-2;A8MV33 O00764 PDXK Pyridoxal kinase 0 34376200.0 13646000.0 9005200.0 11725000.0 False True 18691294.969283957 8607320.487785852 8955796.483954944 1.0 0.4604988847445057 0.4791426436034694 24.155863189476776 -10.21113452071079 8.381051122088586 1.000000129688306 0.4698207641958594 0.9990734252845184 0.00761128268199245 1.8443950511514393e-08 1.7295744749142127e-09 0.007369594634475424 0.002456530922552805 6.1498635402126e-11 10.21113452071079 -0.5301793654924467 VLSIQSHVIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLSIQSHVIR 10 0 O00764;O00764-2;A8MV33 O00764 PDXK Pyridoxal kinase 0 22409300.0 10673000.0 6988300.0 4748000.0 False True 8875072.394069262 6950652.6408310495 5740784.847728401 1.0 0.7831657402001363 0.6468437205723147 23.081327456957165 -10.185181790906878 0.06693737079548276 1.881838953493042 4.1266737133544133e-10 0.9999823933963707 0.0006101540238536068 1.9132140563706002 0.033444491170505214 0.6162939939777321 0.34271298301544273 6.528572165732597e-11 10.185181790906878 -1.8818389530803745 VLSIQSHVIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLSIQSHVIR 10 0 O00764;O00764-2;A8MV33 O00764 PDXK Pyridoxal kinase 0 48511000.0 11894000.0 21461000.0 15156000.0 False True 15397017.46579119 20266676.484264843 12397763.513692379 1.0 1.3162728774772758 0.8052055238124852 23.876147579804538 -6.739310638533282 1.6891666371819969 1.1883328161296938 0.8049486242135202 0.6018404733765459 0.1328870258903709 0.31907820566231276 1.787342285743594 0.06224183564519512 0.1528547545114354 1.822591587873837e-07 6.739310638533282 -0.38338419191617357 VLSK(ub)EFHLNESGDPSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLSKEFHLNESGDPSSK 17 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 818440000.0 261120000.0 234720000.0 322600000.0 True False 342330848.68967676 199700690.9313938 289220446.59771013 1.0 0.5833558141072547 0.8448565114851474 28.350816063851816 -10.512006025026965 5.807664767380103 1.0004188894076038 0.7141061627962011 0.614448242911664 0.106757212659633 0.0005798585961981068 4.8722995528407654e-05 0.10351542049994229 0.03445574222652346 3.076054139923346e-11 10.512006025026965 -0.2863127266114027 VLSK(ub)EFHLNESGDPSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLSKEFHLNESGDPSSK 17 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 852328660.0 350190000.0 239208660.0 262930000.0 True False 339073410.1343144 334725925.39468247 194060745.26907706 1.0 0.9871783377590422 0.5723266392142201 28.33702241290652 -6.91349064776833 0.8716163185857733 1.011470499276675 0.5145077127967068 0.9921737182014227 0.017574181527254484 0.10215506850933019 0.12657775559346582 0.014641291361379821 0.04146484174243497 1.2204201013652026e-07 6.91349064776833 -0.49696278647996817 VLSK(ub)EFHLNESGDPSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLSKEFHLNESGDPSSK 17 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 1980648600.0 775412400.0 486726200.0 718510000.0 True False 1176357301.0397959 399866106.8008423 576496183.5658803 1.0 0.33991892297297427 0.4900689467870932 30.13167917789025 -10.168039452623505 7.982072409077009 1.0000001337799473 0.4149939348825707 0.9529188297235269 0.061298490535222364 1.4595213748053593e-07 1.517961053107682e-08 0.059352021513488486 0.019784002749214102 6.7914193450859e-11 10.168039452623505 -0.5850061988973767 VLSK(ub)EFHLNESGDPSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLSKEFHLNESGDPSSK 17 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 717852000.0 261120000.0 198692000.0 258040000.0 True False 357663120.5026696 189913130.45342085 197096266.50061694 1.0 0.5309832620889504 0.5510667865996708 28.414026125374708 -10.774411792783818 10.810098329141601 1.001671699857542 0.5410250243512532 0.998566029844036 0.008199064547990683 0.0003309649947881803 6.906658076487007e-06 0.00795385300085181 0.0026462367040706253 1.6810793260170814e-11 10.774411792783818 -0.4606466755062887 VLSK(ub)EFHLNESGDPSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLSKEFHLNESGDPSSK 17 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 775598150.0 350190000.0 216522150.0 208886000.0 True False 291198501.0474198 215355702.20166805 252563096.82025993 1.0 0.7395494874700567 0.8673227915384484 28.117427688340797 -10.130263950281233 4.774881923433193 1.0000134094256878 0.8034361395041912 0.7593540795121002 0.0521632329587917 7.676726145795448e-06 1.3982740957888843e-06 0.050510384086564844 0.01683561104362841 7.408598335564578e-11 10.130263950281233 -0.1965772699214966 VLSK(ub)EFHLNESGDPSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLSKEFHLNESGDPSSK 17 1 Q01105-2;A0A0C4DFV9;Q01105-3;Q01105-4;Q01105 Q01105-2;Q01105 SET Protein SET 1 1886752400.0 775412400.0 742930000.0 368410000.0 True False 1003786637.463516 701585292.4120438 301363160.20582014 1.0 0.6989386650781589 0.30022631200524785 29.902805499982698 -7.1196549257649595 0.3441983257171299 1.0458648969372817 1.619231926921707e-14 0.999904459602317 0.002801428542301543 0.07840039468037348 0.016138500093118055 0.006979399366564152 0.03584792186092378 7.591805520631461e-08 7.1196549257649595 -1.0458648969372655 down VLSLLSAPLGSGGFTLLHAAAAAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLSLLSAPLGSGGFTLLHAAAAAGR 25 0 Q9H8Y5;B8ZZS4 Q9H8Y5 ANKZF1 Ankyrin repeat and zinc finger domain-containing protein 1 0 57284000.0 19650000.0 18490000.0 19144000.0 False True 29810486.607425872 15190315.03697063 15360180.00888673 1.0 0.5095628004001345 0.515260962062272 24.829316589369213 -9.904375891954153 6.022594289452259 1.000000122900491 0.5124118812313899 0.9998975804743375 0.002326264758029987 3.836051454517691e-09 7.021858128791659e-10 0.002252396736952637 0.0007507987221276306 1.2463043419510365e-10 9.904375891954153 -0.487588241669101 VLSLLSAPLGSGGFTLLHAAAAAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLSLLSAPLGSGGFTLLHAAAAAGR 25 0 Q9H8Y5;B8ZZS4 Q9H8Y5 ANKZF1 Ankyrin repeat and zinc finger domain-containing protein 1 0 40664600.0 19650000.0 11429000.0 9585600.0 False True 25437312.359407797 10792966.103101572 7841119.15656175 1.0 0.424296637577353 0.30825265836945903 24.600442911461663 -13.999999999999929 0.22515282340285053 4.554607704077244 0.2491643842848477 0.9995035712559792 0.006739325305950783 13.144973799011279 0.15027859247651398 20.832443699963704 0.062107600959022534 1.0000000000001636e-14 13.999999999999929 -4.3054433197923965 VLSLNFSECHTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLSLNFSECHTK 12 0 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4;D6RBM9;D6REX8;D6RBR0;D6RE13;D6RBW8 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 38535000.0 12922000.0 15001000.0 10612000.0 False True 16940867.13682602 12762909.273440003 9513972.03749194 1.0 0.7533799285690648 0.5615988816068623 24.01400438669634 -6.973938912541871 0.13404326925466944 1.2799625966325616 0.030037300266891283 0.9999991089957214 0.0001692829126570855 0.07504400221164545 0.004038028946953297 0.011547098230221388 0.025682407269566183 1.0618449048122104e-07 6.973938912541871 -1.2499252963656704 VLSLNFSECHTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLSLNFSECHTK 12 0 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4;D6RBM9;D6REX8;D6RBR0;D6RE13;D6RBW8 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 17022700.0 7080200.0 3248700.0 6693800.0 False True 6855442.926505541 4545922.851746698 4940492.970304446 1.0 0.6631114722245837 0.7206672162936069 22.70881845009594 -10.578459299340011 6.400817948789947 1.0006173073320896 0.6918893442591003 0.9744961739889603 0.02349703412255434 0.00020738865373650417 1.3658008004971786e-05 0.022794597401022278 0.00758363515349337 2.6396156869329134e-11 10.578459299340011 -0.30872796307298933 VLSLNFSECHTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLSLNFSECHTK 12 0 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4;D6RBM9;D6REX8;D6RBR0;D6RE13;D6RBW8 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 72694000.0 8913000.0 36375000.0 27406000.0 False True 13521672.627582027 29883597.05082783 21989192.087523486 1.0 2.2100518089655656 1.6262183454041839 23.688770287892453 -10.13152540163542 8.998271770929284 0.9999999861758135 1.9181350771848746 0.7673021023092503 0.2383490134145302 6.720622093350828e-08 6.114768171606053e-09 0.23078044332373784 0.07692681329495363 7.387110549436784e-11 10.13152540163542 0.9181350910090611 VLSLNFSECHTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLSLNFSECHTK 12 0 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4;D6RBM9;D6REX8;D6RBR0;D6RE13;D6RBW8 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 36481000.0 12922000.0 10875000.0 12684000.0 False True 17699612.603919666 10394506.541184096 9688300.435179912 1.0 0.5872731100838998 0.5473735867549095 24.07721444821923 -13.999999999989035 0.330394013507969 5.50348696773057 0.5403399620726086 0.9997156588450167 0.0034503009467566886 18.856644532963305 0.18382777918476412 59.02203245991758 0.012767212612021487 1.0000000000252489e-14 13.999999999989035 -4.963147005657961 VLSLNFSECHTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLSLNFSECHTK 12 0 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4;D6RBM9;D6REX8;D6RBR0;D6RE13;D6RBW8 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 13775800.0 7080200.0 2282700.0 4412900.0 False True 5887500.006042274 2270402.642019525 5335616.987055733 1.0 0.38563102160330137 0.9062619076993377 22.489223725530216 -10.2609242232976 8.019088374895167 1.000000419136001 0.6459464646513339 0.38142497733558434 0.212546669211393 1.5927993737046257e-06 1.4646533980476007e-07 0.20579767285432088 0.06859914251229852 5.483726378960371e-11 10.2609242232976 -0.35405395448466714 VLSLNFSECHTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLSLNFSECHTK 12 0 Q9UN86-2;Q9UN86;D6RAC7;D6RB17;D6RGJ4;D6RBM9;D6REX8;D6RBR0;D6RE13;D6RBW8 Q9UN86-2 G3BP2 Ras GTPase-activating protein-binding protein 2 0 51064000.0 8913000.0 24169000.0 17982000.0 False True 11538054.20149627 22823973.903741535 14709460.510901053 1.0 1.978147571952097 1.2748649169106443 23.459896609984902 -10.067754450026074 4.480805615739488 0.9999619297954232 1.6265062438913738 0.514116695147154 0.2871139417799271 44033910.91886907 49469081.64755681 14502.70612620161 0.09828674292070883 8.555503040540622e-11 10.067754450026074 0.6265443140959506 VLSLPKPTIILSAYQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLSLPKPTIILSAYQR 16 1 Q99567;J3KMX1 Q99567 NUP88 Nuclear pore complex protein Nup88 0 11852200.0 5005200.0 3347600.0 3499400.0 False True 4846312.665707968 4684314.137503383 2582802.1602502856 1.0 0.9665728277601916 0.532941710204944 22.208456054327012 -6.9223022885262955 0.8074834293518854 1.0087976222232617 0.4591765488987983 0.9947965002568652 0.015345532572292115 0.09683636614871596 0.09873845549597575 0.013385475590836525 0.04102151681791092 1.1959078358094e-07 6.9223022885262955 -0.5496210733244635 VLSLPKPTIILSAYQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLSLPKPTIILSAYQR 16 1 Q99567;J3KMX1 Q99567 NUP88 Nuclear pore complex protein Nup88 0 68787000.0 19776000.0 24847000.0 24164000.0 False True 30001637.81925982 20412858.719502915 19387974.80854254 1.0 0.680391478707829 0.646230546656898 24.83853792524026 -13.999999999999998 0.31583008910382093 4.197131476079746 0.6391284868257471 0.9996847300233316 0.00282900145753852 17.695306725389248 0.17904165089384827 37.297990401837716 0.011562117661947278 1.0000000000000041e-14 13.999999999999998 -3.558002989253999 VLSLPKPTIILSAYQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLSLPKPTIILSAYQR 16 1 Q99567;J3KMX1 Q99567 NUP88 Nuclear pore complex protein Nup88 0 10897300.0 5005200.0 2520100.0 3372000.0 False True 4162045.5679561035 2506523.7210993147 4077069.609633559 1.0 0.6022336084922343 0.9795831263893935 21.98886132976129 -10.609377171048001 9.346263549177012 1.0000467167632727 0.7909083683332127 0.29046711576408146 0.15405229558887812 0.0001499951101773649 6.269171128382946e-06 0.14919366901656433 0.04972016460506227 2.4582317801328556e-11 10.609377171048001 -0.20913834843006007 VLSLPKPTIILSAYQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLSLPKPTIILSAYQR 16 1 Q99567;J3KMX1 Q99567 NUP88 Nuclear pore complex protein Nup88 0 64004000.0 19776000.0 26192000.0 18036000.0 False True 25600421.84323917 24734392.175381605 14753633.064987866 1.0 0.9661712735375775 0.5763042951139558 24.60966424733271 -6.923985750023313 0.7946113332372512 1.0074305803081822 0.5072867103397095 0.9952182258184682 0.013294520405749128 0.09588320317660741 0.09387679107796298 0.011703368863540859 0.036512009258906776 1.1912810954439697e-07 6.923985750023313 -0.5001438699684727 VLSLQIASIPVECSQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLSLQIASIPVECSQR 16 0 Q12968-5;I3L3K7;H3BR83;H3BRS1;Q12968-6;Q12968-4;Q12968-3;Q12968-2;Q12968 Q12968-5 NFATC3 Nuclear factor of activated T-cells, cytoplasmic 3 0 4504970.0 1971300.0 1684400.0 849270.0 False True 2584393.3900963543 1433094.0857397753 761395.6871730842 1.0 0.5545185540372958 0.29461292158184055 21.301394259612987 -8.860236115707767 0.19396893973554521 1.3839205056243207 8.79207881727285e-11 0.9996561640583216 0.005401074286762178 0.36429090552178084 0.059537487111277244 0.22604360575417395 0.13892048987445377 1.3796339860778134e-09 8.860236115707767 -1.3839205055364 down VLSLQIASIPVECSQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLSLQIASIPVECSQR 16 0 Q12968-5;I3L3K7;H3BR83;H3BRS1;Q12968-6;Q12968-4;Q12968-3;Q12968-2;Q12968 Q12968-5 NFATC3 Nuclear factor of activated T-cells, cytoplasmic 3 0 7000500.0 1971300.0 2252100.0 2777100.0 False True 2700142.882379415 2152594.775301216 2121206.1761698336 1.0 0.7972151360391383 0.7855903441304514 21.36460432113588 VLSSIEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLSSIEQK 8 0 P31947-2;P31947 P31947-2 SFN 14-3-3 protein sigma 0 34851500.0 10654000.0 3863500.0 20334000.0 False True 10315794.601704765 5406215.697886332 15007915.393075772 1.0 0.5240716693790038 1.4548482179545914 23.298351617165142 -6.767737458013047 1.5833890141532858 0.7262291695790872 1.4596080462749874 0.7217337470641236 0.20046437337747103 0.27010273642288235 1.3361325232801151 0.09981936987238518 0.23808164286207578 1.7071140707196145e-07 6.767737458013047 0.7333788766959002 VLSTTK(ub)PFEYETPEMEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLSTTKPFEYETPEMEK 17 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88;H3BR65 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 8911700.0 2055800.0 2826800.0 4029100.0 True False 1990539.7542880278 3955555.9815672557 2973757.839590909 1.0 1.9871775848968518 1.4939454653868778 20.92472825398703 -10.182852657061309 4.801860283929303 0.999911746127089 1.7405615251447615 0.7503612184812762 0.20136116960178674 0.00019027084762195524 3.237883972452637e-05 0.19499015625572547 0.06498903803529664 6.56367914247211e-11 10.182852657061309 0.7406497790176725 VLSTTK(ub)PFEYETPEMEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLSTTKPFEYETPEMEK 17 1 Q16666;Q16666-2;Q16666-3;Q16666-6;H3BR88;H3BR65 Q16666 IFI16 Gamma-interferon-inducible protein 16 1 6258600.0 2055800.0 1668800.0 2534000.0 True False 1709488.7873819536 1659809.843169136 3063847.684107788 1.0 0.9709392980056337 1.7922595963908057 20.705133529421307 -6.898696605101247 0.9694637347953257 0.964619476562263 1.8762268065172334 0.9859064923707592 0.04517258732918451 0.1123721257800662 0.18287823808166942 0.035030357233324504 0.09056208815810549 1.2627093459099766e-07 6.898696605101247 0.9116073299549704 VLSTVHTHSSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLSTVHTHSSVK 12 0 A8MU58;Q13155-2;Q13155 A8MU58 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 0 6461190.0 962690.0 4321300.0 1177200.0 False True 1460471.1120663031 3550130.2525289976 944525.90401491 1.0 2.4308116902813666 0.6467268651952837 20.478002391448225 -6.693162521587482 1.8550517991541873 1.8943431830047048 0.6526214361194198 0.3853430565215399 0.6047476311534569 0.4098957961827519 2.7371497570856973 0.26055326324544803 0.6758381726565069 2.0269240624917834e-07 6.693162521587482 -1.241721746885285 VLSTVHTHSSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLSTVHTHSSVK 12 0 A8MU58;Q13155-2;Q13155 A8MU58 AIMP2 Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 0 2718460.0 962690.0 852800.0 902970.0 False True 1246221.1824569122 805340.9303285511 738638.7252546074 1.0 0.6462263213507812 0.5927027526513301 20.249128713540674 -13.999999999999998 0.26589918277330266 3.6714255546459933 0.5742180922738049 0.999574588338443 0.0037272739139736686 14.686095992777021 0.16320499930846932 21.155740226111348 0.022694729948446506 1.0000000000000041e-14 13.999999999999998 -3.0972074623721886 VLSVAVYNHYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLSVAVYNHYK 11 0 O76031;H0YM48 O76031 CLPX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial 0 12278800.0 5124900.0 5628800.0 1525100.0 False True 6718793.529602197 4789004.980890547 1367297.281792213 1.0 0.7127775187302253 0.2035033932458358 22.67977076585135 -7.200126057001365 0.46900360758244947 1.0149939705451738 1.2356010400010851e-23 0.9993379897743347 0.008474119256279174 0.08789439717005082 0.03351766131873564 0.010304949524723493 0.04703934276882998 6.307742312880158e-08 7.200126057001365 -1.0149939705451738 down VLSVAVYNHYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLSVAVYNHYK 11 0 O76031;H0YM48 O76031 CLPX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial 0 15140300.0 7929100.0 2609500.0 4601700.0 False True 7677395.060669908 3651486.9583627293 3396376.7219591243 1.0 0.4756153525391346 0.44238660315374806 22.872185457022127 -13.999999999999998 0.392271334345195 9.412221878321553 0.4400738617863674 0.9998265484227317 0.003363506271969762 25.66217366474231 0.20554034434182514 183.20204946296738 0.00868871367220936 1.0000000000000041e-14 13.999999999999998 -8.972148016535186 VLSVAVYNHYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLSVAVYNHYK 11 0 O76031;H0YM48 O76031 CLPX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial 0 26683200.0 7487000.0 9982900.0 9213300.0 False True 11358326.373017687 8201373.498246295 7392287.216667155 1.0 0.722058270638278 0.6508253922186924 23.437246936446094 -13.999999999999998 0.1911598404717469 2.495953302393407 0.600314326831002 0.9994888106481764 0.0034060310445729286 12.369802722819868 0.13865148025392068 6.895364899289532 0.048539630825701556 1.0000000000000041e-14 13.999999999999998 -1.8956389755624048 VLSVAVYNHYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLSVAVYNHYK 11 0 O76031;H0YM48 O76031 CLPX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial 0 20934000.0 5124900.0 4698100.0 11111000.0 False True 7019714.025214969 4490522.407460879 8486810.638228014 1.0 0.6397016162383286 1.20899663543888 22.742980827374243 -6.735682102527088 1.7025342826284338 0.7845566514897856 1.2090234723177102 0.5853768869771114 0.15140558823462533 0.32569318398555774 1.8519214833220685 0.07040233393385678 0.17358467065330008 1.837883155803388e-07 6.735682102527088 0.42446682082792464 VLSVAVYNHYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLSVAVYNHYK 11 0 O76031;H0YM48 O76031 CLPX ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial 0 27604700.0 7487000.0 13325000.0 6792700.0 False True 9692069.090833904 12583452.036383625 5556498.298987748 1.0 1.298324632073062 0.5733036204047187 23.208373258538543 -6.794989907159233 1.4764821685505263 1.1656583634313453 0.564512451169256 0.8170475957876108 0.12726279082300815 0.227990800255005 0.9817060766165123 0.06782834536031934 0.15823533323972094 1.6032826499441597e-07 6.794989907159233 -0.6011459122620894 VLSVPESTPFTAVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLSVPESTPFTAVLK 15 0 P61960;H0Y614 P61960 UFM1 Ubiquitin-fold modifier 1 0 8776600.0 1137400.0 4938800.0 2700400.0 False True 1491142.4145972673 4201950.291291616 2420988.5120658926 1.0 2.817940292058886 1.6235796717778705 20.507986621057828 -10.454748349534848 4.912169942811893 0.9974398729679212 2.2207599819185044 0.5821017505614494 0.4875956814275205 0.013687934126403126 0.001519361249703966 0.472701459908623 0.15737082948755796 3.509551748320918e-11 10.454748349534848 1.2233201089505832 VLSVPESTPFTAVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLSVPESTPFTAVLK 15 0 P61960;H0Y614 P61960 UFM1 Ubiquitin-fold modifier 1 0 6767800.0 2712400.0 1139800.0 2915600.0 False True 2626296.346692697 1594928.0839784795 2151916.8938748753 1.0 0.6072917422235984 0.8193732198518993 21.32459828592882 -10.088305258952774 5.067486074244452 1.0000068766684098 0.7133324810368681 0.7089700616685702 0.0865819006838648 6.726780168699747e-06 1.2103149506845296e-06 0.08383457492797282 0.02794418828552721 8.160086097596625e-11 10.088305258952774 -0.28667439563154173 VLSVPESTPFTAVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLSVPESTPFTAVLK 15 0 P61960;H0Y614 P61960 UFM1 Ubiquitin-fold modifier 1 0 7861600.0 1137400.0 3363800.0 3360400.0 False True 1557927.5170792602 3215176.193400924 2566742.7296104245 1.0 2.063752105379464 1.647536680283079 20.57119668258072 -10.134980568963508 4.777098695506345 0.9999395888301276 1.855644392766048 0.8492826524400762 0.1699192357894568 118688120.56225751 10.352327647070963 82375.0974345481 0.05816787399299532 7.328573216255043e-11 10.134980568963508 0.8557048039359204 VLSWIPSNNHQLQLAGALAIANFAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLSWIPSNNHQLQLAGALAIANFAR 25 0 P52306-6;P52306-2;P52306-3;P52306-4;P52306;P52306-5;H0Y8M2 P52306-6 RAP1GDS1 Rap1 GTPase-GDP dissociation stimulator 1 0 95797000.0 28902000.0 30172000.0 36723000.0 False True 43846447.019227706 24787570.86508804 29464682.9537373 1.0 0.5653267835867773 0.6719970478067776 25.38595660664402 -9.934224339357291 6.777953850035924 1.0000000227788575 0.6186619156967829 0.9445679599926605 0.04354795301115578 1.4989527040910046e-08 2.317474411522795e-09 0.042165126706633874 0.014055041397800665 1.1635248432212673e-10 9.934224339357291 -0.3813381070820746 VLTEIIASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLTEIIASR 9 0 P08758;D6RBL5;E9PHT9 P08758 ANXA5 Annexin A5;Annexin 0 14091000.0 3565300.0 4636400.0 5889300.0 False True 4674142.826414313 3944667.1925456533 5279931.730154658 1.0 0.8439338161114207 1.1296042774553094 22.156270388128572 -6.758370584221432 1.6186971189391175 0.9091642654966572 1.1305613676176347 0.6842466231689034 0.06562720388453477 0.28566240879884414 1.4748336203867236 0.03199534160821921 0.07701121217756159 1.7443330753091743e-07 6.758370584221432 0.22139710212097752 VLTFDLTK(ub)YPDANPNPNEQ ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLTFDLTKYPDANPNPNEQ 19 1 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 52912400.0 16027000.0 27977000.0 8908400.0 True False 21011552.20568879 23802940.65349185 7986644.223406817 1.0 1.13285017786774 0.3801072926561069 24.32467940769477 -6.861312357850649 1.1789860946244846 1.072352870186365 0.34271414177255394 0.9552214820516393 0.06941797354916222 0.14546227368210504 0.38344800165466153 0.04589562158273851 0.10730456040092502 1.3762192939216267e-07 6.861312357850649 -0.729638728413811 down VLTFDLTK(ub)YPDANPNPNEQ ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLTFDLTKYPDANPNPNEQ 19 1 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 76386000.0 30702000.0 29100000.0 16584000.0 True False 29727381.815425117 40719781.7544953 12240152.890664339 1.0 1.3697735645648546 0.4117467514180175 24.825289070335188 -6.8020543982888615 1.447444429041787 1.2034944704651394 0.3978313932256252 0.8381147170171097 0.15872228278878733 0.21784068045273708 0.9008037879402296 0.08625676210072283 0.20036162176881936 1.5774136757103932e-07 6.8020543982888615 -0.8056630772395141 down VLTFDLTK(ub)YPDANPNPNEQ ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLTFDLTKYPDANPNPNEQ 19 1 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 174551000.0 88368000.0 63560000.0 22623000.0 True False 134060716.56615847 52217221.40345342 18151554.133986864 1.0 0.38950426896819107 0.13539800919256714 26.998311309406947 -9.560185166733529 0.25965333920632233 1.4221063672567245 1.5497406702874622e-18 0.9989964337814328 0.011494136809274713 0.965812262507624 0.1064059274751133 0.4361123594508965 0.10473886612255645 2.7530546547408685e-10 9.560185166733529 -1.4221063672567245 VLTFDLTK(ub)YPDANPNPNEQ ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLTFDLTKYPDANPNPNEQ 19 1 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 55993000.0 16027000.0 27581000.0 12385000.0 True False 21952615.013389602 26362380.221829765 9459918.077081632 1.0 1.2008765336498866 0.4309244284251204 24.38788946921766 -6.837389671598336 1.2942915592282982 1.1069322027448427 0.40685591576720886 0.9198906961336117 0.09229576660481285 0.17187813279088668 0.5604017283926993 0.055935904102022586 0.12880152153501617 1.4541537526829744e-07 6.837389671598336 -0.7000762869776338 down VLTFDLTK(ub)YPDANPNPNEQ ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLTFDLTKYPDANPNPNEQ 19 1 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 75613000.0 30702000.0 34153000.0 10758000.0 True False 25530073.329215232 33969011.01016025 13007448.060628079 1.0 1.3305489009813363 0.5094951312083801 24.605694345769464 -6.797441708861789 1.4664457019026202 1.1829737612168323 0.4988781437747062 0.8245473958473464 0.14128818741112284 0.22442977034390713 0.9530876449299616 0.0758077109764104 0.17657402197524852 1.594256847994338e-07 6.797441708861789 -0.6840956174421261 VLTFDLTK(ub)YPDANPNPNEQ ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLTFDLTKYPDANPNPNEQ 19 1 Q14683;G8JLG1 Q14683 SMC1A Structural maintenance of chromosomes protein 1A;Structural maintenance of chromosomes protein 1 174397000.0 88368000.0 69532000.0 16497000.0 True False 114394117.9936973 65662483.07645977 13494715.273514343 1.0 0.5740022671452175 0.11796686324604429 26.769437631499397 -7.720112510771017 0.4509222520106829 1.030382644959372 7.826931742933474e-23 0.9970546231832028 0.01954625760855656 0.11621495638599472 0.07958131305829821 0.029146785854780845 0.07611179665596025 1.904967142530039e-08 7.720112510771017 -1.030382644959372 down VLTIDPTEFK(ub)FK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLTIDPTEFKFK 12 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 6429300.0 2090600.0 2850100.0 1488600.0 True False 2740796.8453991977 2424876.189602785 1334573.9516594885 1.0 0.8847340121808995 0.48692917678293207 21.386163965347357 -6.94826624824286 0.5775654160162953 1.004799769253818 0.3472695202792343 0.9990580979838004 0.0067455060002883024 0.08418952186598627 0.03890205572263931 0.007086282315843694 0.03320912665016895 1.1265066291458635e-07 6.94826624824286 -0.6575302489745837 down VLTIDPTEFK(ub)FK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLTIDPTEFKFK 12 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 7694700.0 2493600.0 2840600.0 2360500.0 True False 2414442.0329276314 3974866.3935333085 1742214.2365179192 1.0 1.6462877713877375 0.7215804781220602 21.203258396341997 -6.7188210144396345 1.7637592943961669 1.3936895810873022 0.7231354812748497 0.5068791795987324 0.27199991134890067 0.35760183076668606 2.173480911479698 0.12248578648642482 0.307888919668579 1.910640527619851e-07 6.7188210144396345 -0.6705540998124525 VLTIDPTEFK(ub)FK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLTIDPTEFKFK 12 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 22351700.0 4090600.0 5550100.0 12711000.0 True False 6205739.262917887 4559641.29187078 10198665.278570795 1.0 0.7347458697010861 1.643424714846216 22.565171651946915 -6.828570201297149 1.3342078035368459 0.8581148393037824 1.667182636910213 0.9029923464979231 0.11882999304691241 0.18258798114386163 0.6361578185379921 0.06993792120926572 0.1609652611395801 1.4839859825627652e-07 6.828570201297149 0.8090677976064305 VLTIDPTEFK(ub)FK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLTIDPTEFKFK 12 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 6753700.0 2493600.0 2762900.0 1497200.0 True False 2073538.8852104477 2748015.7093072897 1810257.5977293502 1.0 1.3252781169948438 0.8730280442971405 20.983663671776274 -6.713719006852126 1.7821298895274542 1.199216111064726 0.8739799176074222 0.48260673197895054 0.13699436261333836 0.36767819959255293 2.2785655982954216 0.06112374123084735 0.15457623624362085 1.9332187255318544e-07 6.713719006852126 -0.3252361934573037 VLTIDPTEFK(ub)FK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLTIDPTEFKFK 12 1 P53621;P53621-2;A0A3B3IT15;A0A3B3IS84;A0A3B3ISC6;A0A3B3IU89 P53621 COPA Coatomer subunit alpha;Xenin;Proxenin 1 14795500.0 4090600.0 2312300.0 8392600.0 True False 5295362.33778085 2183618.4723249394 6865232.915348037 1.0 0.4123643167428723 1.2964614085738049 22.336297974039365 -6.727475503617597 1.7320566093179703 0.645386691375488 1.295736534246119 0.5477248249869311 0.24708043804203414 0.34097425421768807 2.0027519841826624 0.11309154369156295 0.28147515734325057 1.8729427233817895e-07 6.727475503617597 0.6503498428706309 VLTNFK(ub)SSEIEQAVQSLDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLTNFKSSEIEQAVQSLDR 19 1 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 1 32501800.0 4544400.0 4550400.0 23407000.0 True False 4400140.509478797 6367398.450022515 17276004.505051874 1.0 1.4470898000429404 3.926239279822053 22.069118163322205 -6.937525758275103 0.6821908824955436 0.9706234975755748 4.548783283640035 0.9978215705737417 0.06007226223016988 0.08891370349940639 0.05988662555905442 0.057432816823414314 0.21580429391517636 1.1547134958847423e-07 6.937525758275103 3.5781597860644605 up VLTNFK(ub)SSEIEQAVQSLDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLTNFKSSEIEQAVQSLDR 19 1 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 1 126804200.0 6836200.0 23005000.0 96963000.0 True False 10371015.193164634 18899578.011114594 77798220.54960746 1.0 1.822345995941747 7.501504828657756 23.30605378714359 -6.932936934182643 0.7222761591795835 0.9223422203429255 8.759687476117836 0.9970846485943563 0.15607353240009716 0.09114133608230948 0.07041756142908728 0.1447608813494837 0.5058238822655642 1.1669790669351482e-07 6.932936934182643 7.837345255774911 VLTNFK(ub)SSEIEQAVQSLDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLTNFKSSEIEQAVQSLDR 19 1 Q9BPX5 Q9BPX5 ARPC5L Actin-related protein 2/3 complex subunit 5-like protein 1 125386200.0 6836200.0 20767000.0 97783000.0 True False 8849595.661648033 19611298.194339838 79987497.33830711 1.0 2.2160671452290606 9.03854824519873 23.07718010923604 -6.937272602379241 0.6844665012638951 0.9186132259015818 10.739558353100348 0.9977843936828821 0.16652436037136295 0.08903326721414194 0.060442824110182945 0.15892635469180555 0.5945966185767313 1.1553867896003122e-07 6.937272602379241 9.820945127198765 VLTPEEQLADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLTPEEQLADK 11 0 O75822-3;O75822;O75822-2 O75822-3 EIF3J Eukaryotic translation initiation factor 3 subunit J 0 7947700.0 1884900.0 1024900.0 5037900.0 False True 1825064.8812420974 1434147.914782892 3718322.856239617 1.0 0.7858065373581917 2.037364750402195 20.79951632218389 -6.862822717461792 1.1714771262427404 0.8828092281845291 2.101296223388364 0.9569751413560229 0.1133667274557148 0.14391733783549626 0.37372226582229917 0.07539011716507948 0.17657014395385498 1.371441485479911e-07 6.862822717461792 1.2184869952038349 up VLTPELYAELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLTPELYAELR 11 0 P12277;G3V4N7;G3V461 P12277 CKB Creatine kinase B-type 0 9698000.0 3198200.0 2958400.0 3541400.0 False True 4192871.1714128526 2517018.2517528776 3174969.899507534 1.0 0.6003089884835955 0.7572304918774023 21.999507072482693 -10.087266245117638 5.057043245672627 1.000007781841461 0.6787697401794481 0.8481941338552853 0.06406293550119146 5.620829051564148e-06 1.014448355733362e-06 0.0620301729861054 0.02067622352491632 8.179631803991433e-11 10.087266245117638 -0.32123804166201286 VLTPELYAELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLTPELYAELR 11 0 P12277;G3V4N7;G3V461 P12277 CKB Creatine kinase B-type 0 8934300.0 3198200.0 2670500.0 3065600.0 False True 4380660.96810523 2552508.479837439 2341568.418013838 1.0 0.5826765637472916 0.5345239987897622 22.062717134005585 -13.999999999999998 0.30477085436705526 4.9129893332529075 0.5232515593670162 0.9996604461766815 0.0038513162711550754 16.905865257178053 0.1754729046402969 41.82871932196434 0.017052570634219125 1.0000000000000041e-14 13.999999999999998 -4.389737773885892 VLTPELYAELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLTPELYAELR 11 0 P12277;G3V4N7;G3V461 P12277 CKB Creatine kinase B-type 0 20230800.0 5617400.0 8852900.0 5760500.0 False True 7271835.035508279 8360228.332675462 4712148.10772136 1.0 1.1496724405672807 0.647999863131108 22.7938880411123 -6.8267448727416715 1.3423027409798778 1.080176169427929 0.6353688246989451 0.8992086006296783 0.06676084428451917 0.18487425610576871 0.6525813219945491 0.03906195443373692 0.08991795089959444 1.4902362632248124e-07 6.8267448727416715 -0.444807344728984 VLTPTQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLTPTQVK 8 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 21737700.0 7214100.0 1865600.0 12658000.0 False True 6985092.344298687 2610543.808975475 9342490.068139724 1.0 0.3737307511913183 1.3374898437477598 22.735847757798016 -6.7313219953831815 1.7184895931932889 0.6236716639370969 1.3370493937985533 0.5653729169183376 0.26324167019762645 0.3337532747648855 1.9315754467936883 0.12136333913914182 0.30069604464470384 1.8564275489227197e-07 6.7313219953831815 0.7133777298614563 VLTPTQVK(ub)NRPTSISWDGLDSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLTPTQVKNRPTSISWDGLDSGK 23 2 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 1 24712200.0 8677400.0 11723500.0 4311300.0 True False 11376155.43206113 9974399.49784509 3865208.0329098147 1.0 0.8767812252050015 0.3397639963688081 23.43950974591405 -6.942909176569829 0.6319190210105716 1.005858931015607 0.18164860186066442 0.9985206635108093 0.01102493302416208 0.08646415151718932 0.048751427437796105 0.01098522420430269 0.045660729078242555 1.1404882714260517e-07 6.942909176569829 -0.8242103291549425 down VLTPTQVK(ub)NRPTSISWDGLDSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLTPTQVKNRPTSISWDGLDSGK 23 2 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 1 40620400.0 16739000.0 14076000.0 9805400.0 True False 16207629.60746534 19696620.205370292 7237071.584305358 1.0 1.215268406448399 0.4465225180721008 23.95016977396799 -6.831952909419928 1.3191422577654741 1.1148779108138274 0.42499541138550945 0.9097306988934744 0.09728677525482603 0.17841105973739266 0.6064819149393431 0.05789340159899159 0.13322796953613744 1.4724721540323849e-07 6.831952909419928 -0.6898824994283179 down VLTPTQVK(ub)NRPTSISWDGLDSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLTPTQVKNRPTSISWDGLDSGK 23 2 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 1 67344900.0 26151900.0 23647000.0 17546000.0 True False 39674344.25998689 19427008.09514571 14078025.409315018 1.0 0.4896617312145118 0.354839523422527 25.241703042516278 -13.999999999999998 0.1868529937287274 3.706640428262251 0.25499330184130714 0.9994914509335001 0.0062660209195604 12.30116200346038 0.1370731072854926 12.110069552296823 0.09509323459737218 1.0000000000000041e-14 13.999999999999998 -3.451647126420944 VLTPTQVK(ub)NRPTSISWDGLDSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLTPTQVKNRPTSISWDGLDSGK 23 2 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 1 31499500.0 8677400.0 14188000.0 8634100.0 True False 11885669.277917685 13561127.246558163 6594903.404871245 1.0 1.1409645455770254 0.5548617625701463 23.502719807436943 -6.843207706156806 1.2674877203961996 1.0749855551908252 0.5343364554610776 0.9298177235634582 0.06617304018027849 0.1650868366160563 0.513804020123409 0.040915499744562676 0.09435440378394665 1.4348030587438897e-07 6.843207706156806 -0.5406490997297476 VLTPTQVK(ub)NRPTSISWDGLDSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLTPTQVKNRPTSISWDGLDSGK 23 2 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 1 40650500.0 16739000.0 18425600.0 5485900.0 True False 13919220.163433446 18326337.635604773 6632976.326064277 1.0 1.316621004655783 0.47653361669567307 23.730575049402265 -6.804601265089763 1.437079763701811 1.1736865377123422 0.46357822090921424 0.8452739030144559 0.1362620656603921 0.21425125322998134 0.8730074911545208 0.07457812096270304 0.17297631745823003 1.5681901978076007e-07 6.804601265089763 -0.7101083168031279 down VLTPTQVK(ub)NRPTSISWDGLDSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLTPTQVKNRPTSISWDGLDSGK 23 2 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 1 76203700.0 26151900.0 37693800.0 12358000.0 True False 33854150.08101772 35596106.89448681 10108970.803787967 1.0 1.0514547495447484 0.29860359157136673 25.012829364608727 -6.890526079261932 1.0192325168940501 1.0399427304083637 0.23317202483606472 0.981234030358738 0.04704371556896079 0.1187186456899437 0.21934670999371197 0.0351430495919082 0.08778253801074004 1.286689985336706e-07 6.890526079261932 -0.806770705572299 down VLTQK(ub)LSSVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLTQKLSSVR 10 1 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 8851780.0 570880.0 1153200.0 7127700.0 True False 748429.2084097847 981147.0551383926 6390193.977726272 1.0 1.3109416951044337 8.538140823370261 19.51350633713854 -6.915926405950071 0.8543825990623117 0.8159477249644389 9.601017065652622 0.9929727079791696 0.2919375141854188 0.10062858161918756 0.11846916452023906 0.24625111456573814 0.7112181919674997 1.2135944845908445e-07 6.915926405950071 8.785069340688183 up VLTQK(ub)LSSVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLTQKLSSVR 10 1 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 22603700.0 1459600.0 6446100.0 14698000.0 True False 2214319.9110533763 5295743.091390822 11792933.857637761 1.0 2.3915889772546817 5.325758847567664 21.078432238033002 -6.95899844043754 0.4493262955069279 0.9047249086596401 6.928811751248801 0.9997312310687474 0.029559089294878632 0.08006085220343218 0.02246801614779949 0.03917905796772751 0.24272874393129443 1.0990097859973506e-07 6.95899844043754 6.024086842589162 VLTQK(ub)LSSVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLTQKLSSVR 10 1 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 13089080.0 570880.0 1385200.0 11133000.0 True False 781949.7634519162 1323997.2837561585 8503614.691332223 1.0 1.693199928741425 10.874886199585287 19.576716398661432 -6.9220208834234365 0.8096164786454857 0.8117801501042268 12.426499617598191 0.994723640015056 0.3269158915535685 0.09699754543824837 0.0995658019265644 0.28472680457057875 0.8700638314116816 1.1966829863937618e-07 6.9220208834234365 11.614719467493964 up VLTQK(ub)LSSVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLTQKLSSVR 10 1 Q9H3M7;Q9H3M7-2 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 17996000.0 1459600.0 6343400.0 10193000.0 True False 1889480.9730173866 5990384.213703254 8337978.589012034 1.0 3.1703861003357834 4.4128407261475555 20.849558560125452 -8.610467138490247 0.26084252192542456 3.427417593746544e-17 5.278974750409099 0.9991691473794241 0.040652615811640154 0.22081237695370412 0.0748997780394929 0.6530347321286236 0.4694755143802048 2.452069986153692e-09 8.610467138490247 5.278974750409099 VLTSGIFETK(ub)FQVDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLTSGIFETKFQVDK 15 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;A0A590UJQ9;S4R3E3;A0A590UJ22;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;P63092-3;A0A590UJF0;A0A590UJG5 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 95474500.0 4164600.0 83103800.0 8206100.0 True False 5391156.7965389155 78479000.47588877 6712674.001696438 1.0 14.556987199161362 1.2451268354884293 22.36216343888197 -6.641936863133768 2.0370454393378186 9.852566237872113 1.3003383723833948 0.16208056428229078 5.79786544417642 0.5286202392150094 4.194530497962114 2.315651275808535 6.421854664001091 2.2806736076845464e-07 6.641936863133768 -8.552227865488717 VLTVINQTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLTVINQTQK 10 0 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 0 16826100.0 1967900.0 8525300.0 6332900.0 False True 2579935.957170708 7253358.4713591235 5677632.257466335 1.0 2.811449040507786 2.2006872851575436 21.298903822794802 -10.152848673841945 5.249448125932737 0.9999462018072661 2.506068162833544 0.890199791417679 0.24934244250551726 0.0001569982031249255 2.5336411519895603e-05 0.24143330063496654 0.0804749272767696 7.033173420415893e-11 10.152848673841945 1.506121961026278 VLTVINQTQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLTVINQTQK 10 0 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 0 16709700.0 6175700.0 2184900.0 8349100.0 False True 5979655.783907263 3057341.964102981 6162220.242368881 1.0 0.5112906285226395 1.0305309310534134 22.511631008071475 -11.745049329991101 13.627576094415714 0.9072277719463332 0.7938197018084174 0.0 0.24383409568904368 0.0 0.0 0.0 0.07070991441195909 1.7986665992777062e-12 11.745049329991101 -0.11340807013791576 VLTVINQTQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLTVINQTQK 10 0 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 0 45450800.0 1336400.0 40547000.0 3567400.0 False True 2027416.5039269226 33311071.054842994 2862301.8263530354 1.0 16.43030476980061 1.411797635468102 20.951211069783493 -6.565828622716438 2.3227682447285822 9.999999999999897 1.439205610395438 0.20715221003028594 6.392167231642757 0.5583918279453705 5.651149657391779 2.4533601798922953 7.551040621146752 2.71751141658007e-07 6.565828622716438 -8.560794389604458 VLTVINQTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLTVINQTQK 10 0 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 0 15787500.0 1967900.0 7477900.0 6341700.0 False True 2695485.81049787 7147501.6518915435 4843921.0714112595 1.0 2.651656196465513 1.7970493677043553 21.362113884317694 -10.371016403876888 5.186581857423947 0.9993306833222878 2.224352782085006 0.7323805660402571 0.34889177686073825 0.0027015595645383276 0.0003276216138871466 0.33797577428781206 0.1126043367841598 4.2558233802246275e-11 10.371016403876888 1.2250220987627185 VLTVINQTQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLTVINQTQK 10 0 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 0 9100500.0 6175700.0 1606200.0 1318600.0 False True 5135368.179898196 1597547.0817942617 1594313.1634824483 1.0 0.3110871559409654 0.3104574214801584 22.29203628350575 VLTVINQTQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLTVINQTQK 10 0 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 0 6037900.0 1336400.0 1780500.0 2921000.0 False True 1729996.1443823234 1681413.6098147102 2389407.9719909895 1.0 0.9719175474897032 1.3811637556244971 20.722337391875943 -6.890460858686245 1.0196750408218287 0.9782529707944511 1.4166792143085085 0.9811908170640284 0.02559893366015937 0.1187691397025655 0.21968103735368585 0.019117409453223277 0.04773874315212971 1.2868832297058334e-07 6.890460858686245 0.43842624351405746 VLTVINQTQK(ub)ENLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLTVINQTQKENLR 14 1 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 1 64480900.0 4727600.0 9831300.0 49922000.0 True False 6197929.382143518 8364508.362107255 44756550.325638145 1.0 1.3495649670042607 7.221210111651732 22.5633548865891 -6.919103478572575 0.8313466580707819 0.8662115773358634 8.148818865481458 0.9939282670130773 0.22237839807117782 0.09870227869485168 0.1083681943444961 0.1906974936406947 0.566426519571687 1.2047488528081483e-07 6.919103478572575 7.282607288145594 up VLTVINQTQK(ub)ENLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLTVINQTQKENLR 14 1 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 1 61481700.0 7499700.0 10209000.0 43773000.0 True False 7261626.128628235 14285506.939231694 32307538.13814824 1.0 1.9672600442637098 4.449077598580709 22.791861222918776 -6.954902274619286 0.5021504275973634 0.9512100118997054 5.572562772633908 0.9995319518789514 0.03142675824642098 0.08157493021274971 0.028262573333788978 0.03670812986006149 0.20474391170929207 1.1094244309772097e-07 6.954902274619286 4.621352760734203 VLTVINQTQK(ub)ENLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLTVINQTQKENLR 14 1 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 1 57972000.0 10936000.0 14779000.0 32257000.0 True False 16590711.528692594 12141571.981145965 25881389.81125465 1.0 0.7318294914686376 1.5599927565791505 23.983872424941943 -6.81952519510431 1.3738042587973769 0.8553796452574179 1.577904342572176 0.8832908484830577 0.11786890789262319 0.19411664405254567 0.7199942122268781 0.06742118897042604 0.15542436048353273 1.5152168975502967e-07 6.81952519510431 0.722524697314758 VLTVINQTQK(ub)ENLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLTVINQTQKENLR 14 1 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 1 45819700.0 4727600.0 8994100.0 32098000.0 True False 6475521.478586168 8596710.922488637 24517113.479060646 1.0 1.3275704436958486 3.7861218683523825 22.62656494811199 -6.9313034714753465 0.7360128665081215 0.9643627324277096 4.308024694860139 0.9967883110246619 0.0704653195042508 0.09196657907411154 0.07440536104691216 0.06470243237963474 0.22088345434395215 1.1713765579994321e-07 6.9313034714753465 3.3436619624324293 up VLTVINQTQK(ub)ENLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLTVINQTQKENLR 14 1 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 1 43719700.0 7499700.0 10484000.0 25736000.0 True False 6236332.843043312 10427520.61108893 31117278.61018069 1.0 1.6720596660777858 4.989675726639945 22.572266498353052 -6.940090760240621 0.6587179173581965 0.9628182189837993 5.886727049969435 0.9981757732586074 0.07449055141419238 0.087725236602728 0.0544211425407838 0.07256094460531229 0.2854265498440747 1.1479137017757398e-07 6.940090760240621 4.923908830985636 VLTVINQTQK(ub)ENLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLTVINQTQKENLR 14 1 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 1 50975000.0 10936000.0 20367000.0 19672000.0 True False 14156867.580787977 19233558.545968134 16091897.851765411 1.0 1.3586027019190063 1.1366849170506779 23.754998747034392 -10.132058556891913 4.052712986846389 0.9999287294127382 1.2476438093312054 0.6241149137060622 0.09059755655598309 11378060.795624666 7128491.736286713 6914.525775461536 0.031013952471786645 7.37804743566023e-11 10.132058556891913 0.2477150799184672 VLVALYEEPEKPNSALDFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLVALYEEPEKPNSALDFLK 20 1 Q99417;A0A087WV05 Q99417 MYCBP C-Myc-binding protein 0 47644200.0 4187200.0 30816000.0 12641000.0 False True 6352288.52532386 25316644.033493076 10142500.809252864 1.0 3.985436733952879 1.596668786189268 22.598845011496557 -6.590565345358574 2.2267367297729086 3.0198745197895693 1.6036502982403757 0.0 1.293500456931192 0.6678652971327457 6.243905835946818 0.48478460715484534 1.4415428782461617 2.567051932073789e-07 6.590565345358574 -1.4162242215491936 VLVALYEEPEKPNSALDFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLVALYEEPEKPNSALDFLK 20 1 Q99417;A0A087WV05 Q99417 MYCBP C-Myc-binding protein 0 15690000.0 9538100.0 2789900.0 3362000.0 False True 7931352.759474562 2774870.25494821 4064978.655868334 1.0 0.34986090508122103 0.5125202193298526 22.91913552011388 -10.465531324245104 9.271603871511285 1.0000063035463391 0.43119056220689345 0.942212436246471 0.06640538697002811 8.652646151053517e-06 4.987651753128766e-07 0.06429745063834547 0.02143224648611482 3.423486942407372e-11 10.465531324245104 -0.5688157413394457 VLVDQTTGLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLVDQTTGLSR 11 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 0 12360900.0 1163400.0 6495800.0 4701700.0 False True 1525228.666381625 5526651.960430079 4215213.185891054 1.0 3.623490747483279 2.763659822819231 20.540594120933545 -9.993930375190049 5.800134784318093 0.9999967951161474 3.193575285151943 0.8966724518953647 0.3510245050844982 1.454826066477189e-05 2.5217588736799044e-06 0.3398785112625557 0.11329267185822446 1.0140739460487384e-10 9.993930375190049 2.1935784900357955 VLVDQTTGLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLVDQTTGLSR 11 0 Q15717;Q15717-2 Q15717 ELAVL1 ELAV-like protein 1 0 8688000.0 1163400.0 3094200.0 4430400.0 False True 1593540.4197028407 2957488.012848905 3384030.766952149 1.0 1.8559228095390323 2.1235926777327645 20.603804182456436 -10.583085884310329 0.2442560171666771 4.1876440034177414e-10 2.268172623215438 0.9991885934772988 0.013650164459145802 2.2790033091827406 0.12307463221598275 1.4999500658759317 0.12557576296527967 2.6116448350683086e-11 10.583085884310329 2.2681726227966736 VLVEPDAGAGVAVMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLVEPDAGAGVAVMK 15 0 P42126-2;P42126 P42126-2 ECI1 Enoyl-CoA delta isomerase 1, mitochondrial 0 6203190.0 2217100.0 987290.0 2998800.0 False True 2146719.3740791827 1381520.0456493357 2213324.3179283794 1.0 0.6435494374954934 1.031026385960562 21.033702179204937 -6.664891248202138 1.9558468565395772 0.7714799751405439 1.0294170569319665 0.25643781188216375 0.15159441142419672 0.47297407283957627 3.4831197295005736 0.06251461184215999 0.16812177846014667 2.163260158466059e-07 6.664891248202138 0.2579370817914226 VLVEPDAGAGVAVMK(ub)FK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLVEPDAGAGVAVMKFK 17 1 P42126-2;P42126 P42126-2 ECI1 Enoyl-CoA delta isomerase 1, mitochondrial 1 78224700.0 3759700.0 19894000.0 54571000.0 True False 5703739.770887483 16343760.267468544 43785017.93068105 1.0 2.865446342922042 7.676545510397339 22.443476730661658 -6.954791227814378 0.5035084617952316 0.9065101716930257 9.844229533423945 0.9995255980893133 0.06126332601162796 0.08161703719478437 0.028427809339516705 0.07138075721093161 0.39692700013607135 1.1097081412138519e-07 6.954791227814378 8.93771936173092 VLVEPDAGAGVAVMK(ub)FK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLVEPDAGAGVAVMKFK 17 1 P42126-2;P42126 P42126-2 ECI1 Enoyl-CoA delta isomerase 1, mitochondrial 1 62079700.0 3759700.0 14199000.0 44121000.0 True False 4867005.764766691 13408813.168075882 36091430.71969005 1.0 2.7550436174013155 7.415530711092173 22.214603052754107 -6.954156299109732 0.5111852022433433 0.9150566959485386 9.460392850607658 0.9994883665991819 0.061234528622879605 0.08185852278814558 0.029378545306156644 0.07038675756647134 0.384672174109974 1.1113316959150286e-07 6.954156299109732 8.54533615465912 VLVK(ub)VHPEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLVKVHPEGK 10 1 P62195;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 6885700.0 1604800.0 2256500.0 3024400.0 True False 2103908.3409053064 1919838.9957681084 2711464.10009335 1.0 0.9125107584021491 1.2887748232067058 21.004640422717777 -6.84548825926284 1.2567998332505463 0.9534376045878817 1.3025460272620355 0.9334588245966722 0.04147127802832767 0.16249179036819855 0.4962048863658821 0.0258488990775837 0.05966377795813894 1.4272884150245273e-07 6.84548825926284 0.34910842267415376 VLVK(ub)VHPEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLVKVHPEGK 10 1 P62195;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 11084500.0 1726500.0 4209700.0 5148300.0 True False 1671693.2025383213 5890655.163295482 3799805.784310614 1.0 3.523765697169213 2.2730281959279 20.67287867045738 -9.105488543001126 11.034586131939532 1.0000004208311613 2.89839694653958 0.7544030415603068 0.510611446701358 0.0 0.0 0.49439740736406157 0.1647991357880205 7.843528103968397e-10 9.105488543001126 1.8983965257084188 VLVK(ub)VHPEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLVKVHPEGK 10 1 P62195;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 17622100.0 4689800.0 5281100.0 7651200.0 True False 7114769.470305651 4338646.443577367 6138936.966359904 1.0 0.6098084360547775 0.8628441149051277 22.76238558125023 -10.124835864704657 5.05023150245209 1.0000100296405328 0.7363262754793768 0.5914700837274683 0.10330138331901882 1.16660363233997e-05 2.021734906571684e-06 0.10002493809143162 0.03334037810260907 7.5017767452603e-11 10.124835864704657 -0.26368375416115597 VLVK(ub)VHPEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLVKVHPEGK 10 1 P62195;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 6298000.0 1604800.0 1143000.0 3550200.0 True False 2198137.928089325 1092498.480604453 2711715.87866412 1.0 0.4970108866435326 1.2336422769526614 21.06785048424067 -6.722855504089546 1.7487976101724416 0.6949321184928734 1.2327029896015997 0.526086654392566 0.21158845849388824 0.3497888637407949 2.0920935827704175 0.09600726106301753 0.24023054865297905 1.8929733328561956e-07 6.722855504089546 0.5377708711087263 VLVK(ub)VHPEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLVKVHPEGK 10 1 P62195;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 9663600.0 1726500.0 5286800.0 2650300.0 True False 1435661.2469184473 5258318.959052364 3204465.476397342 1.0 3.6626460248467394 2.2320484607880284 20.453283945891656 -9.806281951243736 6.212226408564257 0.9999999254324428 2.9473472428187217 0.7118597807148112 0.5840390098735145 6.040857568412372e-07 1.166537818228827e-07 0.565493364970645 0.18849777989726377 1.5621331503869792e-10 9.806281951243736 1.947347317386279 VLVK(ub)VHPEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLVKVHPEGK 10 1 P62195;P62195-2;J3KRP2;J3QSA9;J3QLH6 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 19316900.0 4689800.0 7406300.0 7220800.0 True False 6071038.549778668 6994132.894339052 5906688.491664689 1.0 1.1520488359597119 0.9729288396431002 22.533511903342678 -6.681791125596953 1.8952372792861731 1.0960497808848086 0.9735973508182865 0.3323356716524437 0.06441726044371893 0.4346339627795374 3.0198199765085403 0.02725578587595781 0.07172829641303399 2.0806971600554898e-07 6.681791125596953 -0.12245243006652218 VLVLLSGGVDSTVCTALLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLVLLSGGVDSTVCTALLNR 20 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 31433300.0 7868300.0 12050000.0 11515000.0 False True 11936786.349781638 9899583.35292029 9239055.2027962 1.0 0.8293340487828522 0.7739985396459083 23.508911147273434 -13.999999999995964 0.15751587018177182 1.8362444923897956 0.718081975302391 0.9995431208841644 0.0020559396059922435 11.9939794167025 0.12533150701109555 3.0650795869861875 0.05080851735710931 1.000000000009293e-14 13.999999999995964 -1.1181625170874046 VLVMLAAQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLVMLAAQSR 10 0 Q969Z0;C9IZN7;C9J7P5 Q969Z0 TBRG4 Protein TBRG4 0 3708170.0 933130.0 960940.0 1814100.0 False True 1223342.4664437755 817571.4977147814 1626394.334075963 1.0 0.668309586351106 1.3294677317986423 20.222396902443133 -6.770282866007959 1.5731870287690388 0.8098243270389235 1.3332442587744053 0.7317315162464046 0.1398026400328744 0.2659590672562899 1.2990421820345952 0.07004232911308107 0.16669907951920396 1.6971379073586057e-07 6.770282866007959 0.5234199317354818 VLVMLAAQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLVMLAAQSR 10 0 Q969Z0;C9IZN7;C9J7P5 Q969Z0 TBRG4 Protein TBRG4 0 4498830.0 933130.0 1018300.0 2547400.0 False True 1278133.377890076 973308.1389322081 1945756.5853498336 1.0 0.7615074887872273 1.5223423619230259 20.285606963966025 -6.822476153000812 1.361251964567404 0.8717655127550615 1.5398325785387803 0.8899476391037735 0.10540528454050317 0.1902917712617192 0.692197029219213 0.06083927083249376 0.14013198148748668 1.5049561532921506e-07 6.822476153000812 0.6680670657837188 VLVNDAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLVNDAQK 8 0 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 0 3238950.0 975860.0 540590.0 1722500.0 False True 944881.8584587584 756450.4061396079 1271325.5761076545 1.0 0.8005767063551098 1.3454862792914384 19.849774430362384 -6.80769165578972 1.4245287459618092 0.8910162661912726 1.3544954851514928 0.8536274106991506 0.08612279572363131 0.20997224563149863 0.8402644215259009 0.047546846237380355 0.11008918136227988 1.5570707420104243e-07 6.80769165578972 0.46347921896022015 VLVNDAQK(ub)VTEGQQER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLVNDAQKVTEGQQER 16 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 141376300.0 51679600.0 45639100.0 44057600.0 True False 67752456.06595828 38829924.179818474 39498942.18234119 1.0 0.5731146357560355 0.5829890822539072 26.013769910160747 -10.662611786869698 6.614019746760775 1.0024760919812454 0.5780518590049716 0.9995894262549379 0.004031225902033011 0.0001478408397455279 7.541518670468267e-06 0.003920540606638458 0.0013010725652811566 2.1746442112073826e-11 10.662611786869698 -0.42442423297627385 VLVNDAQK(ub)VTEGQQER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLVNDAQKVTEGQQER 16 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 191018900.0 51455700.0 47043600.0 92519600.0 True False 49822266.9689262 65828354.809133045 68285941.23149468 1.0 1.3212637403711422 1.370590809809681 25.57028733152332 -12.429146989113905 0.2903790486476335 1.4377009001298037e-06 1.3848166272482099 0.9995085972882688 0.003642362955276044 6.613344124309864 0.1643195500833906 3.9301624459265687 0.01859265581152596 3.7226568976769144e-13 12.429146989113905 1.3848151895473098 VLVNDAQK(ub)VTEGQQER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLVNDAQKVTEGQQER 16 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 455829500.0 119264300.0 98457200.0 238108000.0 True False 180932662.48824576 80886743.41038533 191045849.43355638 1.0 0.4470544029917214 1.0558947555749787 27.430877630055612 -6.66765831919416 1.9459679958517375 0.6463378654103343 1.053392668192499 0.26855168875325264 0.23500892301107368 0.46654120014470907 3.40382152460103 0.09730916234814506 0.260754273793159 2.1495209427878104e-07 6.66765831919416 0.40705480278216466 VLVNDAQK(ub)VTEGQQER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLVNDAQKVTEGQQER 16 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 153099000.0 51679600.0 46814300.0 54605100.0 True False 70786944.70867711 44745889.43181195 41708500.007335484 1.0 0.632120649025935 0.5892117561929866 26.076979971683638 -13.999999999999998 0.30321136731184745 4.418378978584072 0.5790011495184012 0.9996569828495365 0.0034146199260535882 16.800522312011797 0.174972784323303 36.096216182920344 0.015295846842995363 1.0000000000000041e-14 13.999999999999998 -3.839377829065671 VLVNDAQK(ub)VTEGQQER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLVNDAQKVTEGQQER 16 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 185538000.0 51455700.0 88744000.0 45338300.0 True False 42787694.424014784 88265918.45769522 54818328.90938595 1.0 2.062880920458186 1.2811704310625094 25.350692606957598 -10.062914355307381 4.469350823121808 0.9999591772712649 1.672025675114952 0.49632663055649273 0.3191319711027725 47193345.59387348 35419215.266991146 17832.086607581306 0.10924736568843968 8.651385108958577e-11 10.062914355307381 0.6720664978436871 VLVNDAQK(ub)VTEGQQER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLVNDAQKVTEGQQER 16 1 Q13263;Q13263-2 Q13263 TRIM28 Transcription intermediary factor 1-beta 1 437543100.0 119264300.0 98139800.0 220139000.0 True False 154389987.40082064 92678233.85818252 180075960.81688616 1.0 0.6002865562620668 1.1663707203329234 27.20200395214806 -6.716952225935898 1.770188045446827 0.7560466589076147 1.1653521383802472 0.4982955767916937 0.16826445651048869 0.361192562861191 2.2102324915508147 0.07552326045526596 0.19028138447201526 1.9188798132236657e-07 6.716952225935898 0.4093054794726325 VLVQVSYAIGVSHPLSISIFHYGTSQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLVQVSYAIGVSHPLSISIFHYGTSQK 27 0 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 577687000.0 110846000.0 236949000.0 229892000.0 False True 168161485.92807785 194663599.65901315 184453745.43475693 1.0 1.1575991885696715 1.0968846071784073 27.325272081677646 -10.325339320763419 4.636834378497379 0.9999053101645142 1.1272418978738297 0.8541457739370267 0.024786624060071465 2.428306653643902e-05 3.5331529788242924e-06 0.024017382293349085 0.007999848515992088 4.727817231986557e-11 10.325339320763419 0.12733658770931544 VLVQVSYAIGVSHPLSISIFHYGTSQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLVQVSYAIGVSHPLSISIFHYGTSQK 27 0 P31153;P31153-2 P31153 MAT2A S-adenosylmethionine synthase isoform type-2 0 362411000.0 110846000.0 117910000.0 133655000.0 False True 143492332.10131896 111348204.8487799 109331161.41610944 1.0 0.7759871431329006 0.7619303402143569 27.096398403770095 -13.999999999999996 0.39371545380254364 4.626980256149511 0.76098108107091 0.9998286872145115 0.0014275017075374684 25.862857402179888 0.2060687805616482 79.94412343558281 0.0036603909195028887 1.0000000000000082e-14 13.999999999999996 -3.865999175078601 VLVSLSAGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLVSLSAGGR 10 0 Q6P452;P09525-2;P09525 Q6P452 ANXA4 Annexin;Annexin A4 0 13234200.0 4787500.0 5300500.0 3146200.0 False True 6276458.862215952 4509686.06118718 2820661.404481449 1.0 0.7185080250163546 0.4494033126643633 22.58151939869264 -6.971672537391786 0.21451029241060685 1.1330320948197896 0.027328396319622063 0.9999926542058688 0.0006092485154473716 0.07576365476367666 0.007054800601763048 0.007777235236321755 0.02760200279491757 1.0674006491996151e-07 6.971672537391786 -1.1057036985001676 down VLVSLSAGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLVSLSAGGR 10 0 Q6P452;P09525-2;P09525 Q6P452 ANXA4 Annexin;Annexin A4 0 9954000.0 3400200.0 2131300.0 4422500.0 False True 3292262.5121753844 2982339.2045826744 3264114.5778438887 1.0 0.9058631240836484 0.9914502764504958 21.650647944547313 -10.246837517887457 5.215246054988165 1.0000060611367683 0.9486567005155837 0.3242475750412379 0.03494080863947575 2.462727790520092e-06 3.55661767457756e-07 0.033835285959691104 0.011277097496970033 5.664511751489466e-11 10.246837517887457 -0.05134936062118456 VLVSLSAGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLVSLSAGGR 10 0 Q6P452;P09525-2;P09525 Q6P452 ANXA4 Annexin;Annexin A4 0 13339600.0 4787500.0 4444000.0 4108100.0 False True 6557568.127322812 4247649.3856572155 3137851.3889752934 1.0 0.6477476563238327 0.4785083933632498 22.644729460215533 -13.999999999965594 0.09693445270742063 2.7564076071759676 0.10028270660096207 0.9998089704811992 0.0030023244566743405 12.104470296956158 0.09208538711586198 4.2878513722260605 0.3379721764900057 1.0000000000792234e-14 13.999999999965594 -2.6561249005750054 VLVSLSAGGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLVSLSAGGR 10 0 Q6P452;P09525-2;P09525 Q6P452 ANXA4 Annexin;Annexin A4 0 6638400.0 3400200.0 1604200.0 1634000.0 False True 2827416.9544002926 1595557.85619123 1975661.8452376158 1.0 0.5643164350797545 0.6987515025553287 21.43105321998159 -10.768622226511164 10.402711788477744 1.001443581024199 0.6315339688175432 0.9092256451694758 0.054882886475297245 0.001842494305803746 4.098079981473955e-05 0.05328462261807189 0.017713375442551544 1.7036397846670737e-11 10.768622226511164 -0.36990961220665586 VLVTGAAGQIAYSLLYSIGNGSVFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLVTGAAGQIAYSLLYSIGNGSVFGK 26 0 P40925;P40925-3;A0A5K1VW95;C9JF79;C9JLV6;C9IZI0;F8WFC2 P40925 MDH1 Malate dehydrogenase, cytoplasmic;Malate dehydrogenase 0 2442050000.0 1011700000.0 716830000.0 713520000.0 False True 1534822865.1772408 588906085.8816462 572492459.2530745 1.0 0.3836964507390496 0.3730023002927854 30.51542501689346 VLVTGAAGQIAYSLLYSIGNGSVFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLVTGAAGQIAYSLLYSIGNGSVFGK 26 0 P40925;P40925-3;A0A5K1VW95;C9JF79;C9JLV6;C9IZI0;F8WFC2 P40925 MDH1 Malate dehydrogenase, cytoplasmic;Malate dehydrogenase 0 1569890000.0 1011700000.0 179860000.0 378330000.0 False True 1309665593.5884423 169850632.8903532 309477821.99361587 1.0 0.12969007792666207 0.2363029337478863 30.28655133898591 -10.606758477968478 6.4976524232444905 1.0022755018104545 0.18299650583727445 0.9873898212485547 0.0435245161304851 0.001437052482623225 8.697109483830411e-05 0.04221072079202139 0.014047477177092073 2.473099114971141e-11 10.606758477968478 -0.8192789959731801 VLVTGAGK(ub)GIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLVTGAGKGIGR 12 1 J3QS36;Q7Z4W1 J3QS36 DCXR L-xylulose reductase 1 5305710.0 827310.0 1316800.0 3161600.0 True False 801047.4968965976 1842605.1070212827 2333482.1140330676 1.0 2.3002445100444944 2.9130383941943494 19.611528262021658 -9.361293172736811 0.228281107991758 4.933518430767931e-23 3.38315985502657 0.999283296223845 0.021353508526853495 0.7797531894924676 0.08736809012466713 0.864846498542561 0.29680397339361914 4.3521797835108004e-10 9.361293172736811 3.38315985502657 VLVTGAGK(ub)GIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLVTGAGKGIGR 12 1 J3QS36;Q7Z4W1 J3QS36 DCXR L-xylulose reductase 1 3232610.0 827310.0 2405300.0 0.0 True False 687944.9210472621 2392342.1714853314 0.0 1.0 3.477519926803815 0.0 19.391933537455934 -6.715450813035725 1.775771711237698 2.514688082631661 0.006891091356973558 0.4907109737217935 1.0431929883983422 0.3643538339064629 2.2428472530118055 0.4669128805316103 1.1784055032985457 1.9255251122549594e-07 6.715450813035725 -2.5077969912746876 VLVTGAGK(ub)GIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLVTGAGKGIGR 12 1 J3QS36;Q7Z4W1 J3QS36 DCXR L-xylulose reductase 1 3535910.0 725080.0 924130.0 1886700.0 True False 938630.3534635834 872701.3531244413 1543339.95917679 1.0 0.9297604215590712 1.6442468043802376 19.840197589483708 -6.882741684532265 1.0644198662892985 0.9546679779462769 1.6976152500391666 0.9758292870389125 0.04998924823140311 0.12522788456891626 0.2578613596472524 0.0360841994888708 0.08789935864898359 1.3099608473215276e-07 6.882741684532265 0.7429472720928897 VLVTGATGLLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLVTGATGLLGR 12 0 Q9NZL9;Q9NZL9-2;Q9NZL9-4;Q9NZL9-3;E5RJR3;Q9NZL9-5 Q9NZL9 MAT2B Methionine adenosyltransferase 2 subunit beta 0 28355300.0 9384100.0 8648200.0 10323000.0 False True 12302645.97575366 7357922.270419566 9254874.98520818 1.0 0.5980764044515895 0.7522670329169759 23.552465298927626 -10.042257623529856 4.9593778306755745 1.000005778931211 0.6751717186814328 0.8554368763034018 0.06294806048641134 4.022155382143755e-06 7.76867604673896e-07 0.06095028071857661 0.020316399160250544 9.072821706426514e-11 10.042257623529856 -0.3248340602497781 VLVTGATGLLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLVTGATGLLGR 12 0 Q9NZL9;Q9NZL9-2;Q9NZL9-4;Q9NZL9-3;E5RJR3;Q9NZL9-5 Q9NZL9 MAT2B Methionine adenosyltransferase 2 subunit beta 0 17030500.0 5671800.0 2026800.0 9331900.0 False True 5491751.813586356 2836111.8096223716 6887595.439000885 1.0 0.5164311691227477 1.2541709226482654 22.38883499717648 -6.729887082849237 1.7238647373689353 0.7089522120938954 1.2537054672629833 0.558666699775368 0.2032820386522097 0.33643836166298424 1.9586882275629591 0.09345538137431919 0.2319131088369356 1.8625713447733124e-07 6.729887082849237 0.5447532551690879 VLVTGATGLLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLVTGATGLLGR 12 0 Q9NZL9;Q9NZL9-2;Q9NZL9-4;Q9NZL9-3;E5RJR3;Q9NZL9-5 Q9NZL9 MAT2B Methionine adenosyltransferase 2 subunit beta 0 14236200.0 3172100.0 8570400.0 2493700.0 False True 4812307.611573318 7040945.159159173 2000819.1019724626 1.0 1.4631120301258616 0.4157712398020047 22.198297434512128 -6.78650491759208 1.5102746913086005 1.2600126733407335 0.40568000763212786 0.7898059903974712 0.1964664449431451 0.24059811079481042 1.0841792446524097 0.10241540524319491 0.24040355205113081 1.6349146386017345e-07 6.78650491759208 -0.8543326657086057 down VLVTGATGLLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLVTGATGLLGR 12 0 Q9NZL9;Q9NZL9-2;Q9NZL9-4;Q9NZL9-3;E5RJR3;Q9NZL9-5 Q9NZL9 MAT2B Methionine adenosyltransferase 2 subunit beta 0 20990200.0 9384100.0 5307500.0 6298600.0 False True 12853655.365767086 5072997.100444563 4811000.403738901 1.0 0.39467349606675983 0.37429044632330455 23.615675360450517 VLVTGATGLLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLVTGATGLLGR 12 0 Q9NZL9;Q9NZL9-2;Q9NZL9-4;Q9NZL9-3;E5RJR3;Q9NZL9-5 Q9NZL9 MAT2B Methionine adenosyltransferase 2 subunit beta 0 10853800.0 5671800.0 2650500.0 2531500.0 False True 4716353.003343204 2636221.2304169405 3060824.9456664766 1.0 0.5589533329138522 0.648981308968349 22.169240272610757 -9.936103403476915 5.617145261758058 1.0000004184747877 0.603967320940505 0.9626887253548577 0.03675376732032413 1.9261021393492652e-07 3.6440152239350305e-08 0.035586719833591414 0.011862227394853288 1.1585014895502295e-10 9.936103403476915 -0.39603309753428273 VLVTGATGLLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLVTGATGLLGR 12 0 Q9NZL9;Q9NZL9-2;Q9NZL9-4;Q9NZL9-3;E5RJR3;Q9NZL9-5 Q9NZL9 MAT2B Methionine adenosyltransferase 2 subunit beta 0 13189100.0 3172100.0 7111900.0 2905100.0 False True 4106345.9814390605 6716116.513137461 2376401.6088432125 1.0 1.6355457001175073 0.5787144141250385 21.969423756604577 -6.7438790510343205 1.6724739385996736 1.3764540779155239 0.5775627865140762 0.6221499620485438 0.2670205548676384 0.3108869454042497 1.7088751614433189 0.1262286912105873 0.3084472755413609 1.8035199427270472e-07 6.7438790510343205 -0.7988912914014477 VLVVGAGGIGCELLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLVVGAGGIGCELLK 15 0 Q9UBT2;K7EPL2;U3KQ55;K7ES38 Q9UBT2 UBA2 SUMO-activating enzyme subunit 2 0 2671440.0 1719900.0 0.0 951540.0 False True 2254805.555535295 0.0 853083.7686161957 1.0 0.0 0.3783402815031968 21.104571596525368 -10.64480366027865 6.553427870954289 1.0038122040732682 0.18917014075160915 0.8596288258541883 0.1544567731372968 0.008614936505923074 0.0004669296636859701 0.14975841032327264 0.04985070917247397 2.265668359646015e-11 10.64480366027865 -0.8146420633216591 VLVVGAGGIGCELLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLVVGAGGIGCELLK 15 0 Q9UBT2;K7EPL2;U3KQ55;K7ES38 Q9UBT2 UBA2 SUMO-activating enzyme subunit 2 0 17460900.0 3721500.0 8234200.0 5505200.0 False True 5645787.578093405 6764742.675901753 4417094.806985122 1.0 1.198192915041664 0.7823699963711325 22.42874341794947 -6.7770807607763 1.5470584147047055 1.1126476157872962 0.7793621134707457 0.7569787592267784 0.08371687513729169 0.25514153281907426 1.2059101671806425 0.04262840099960673 0.10084114693814987 1.6707798895989513e-07 6.7770807607763 -0.3332855023165505 VLVVGAGGIGCELLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLVVGAGGIGCELLK 15 0 Q9UBT2;K7EPL2;U3KQ55;K7ES38 Q9UBT2 UBA2 SUMO-activating enzyme subunit 2 0 9567700.0 1719900.0 3105000.0 4742800.0 False True 2355793.5085498723 2967810.833138079 3622648.321032111 1.0 1.2597924318778426 1.5377613988171914 21.16778165804826 -6.970265464882818 0.2517719616612504 0.9136864536140754 1.892027047383402 0.9999843770945295 0.0008678965693818389 0.07621673561628858 0.008721738029764229 0.006126042474375722 0.026564240169331853 1.0708645333251765e-07 6.970265464882818 0.9783405937693266 VLVVGAGGIGCELLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLVVGAGGIGCELLK 15 0 Q9UBT2;K7EPL2;U3KQ55;K7ES38 Q9UBT2 UBA2 SUMO-activating enzyme subunit 2 0 14136300.0 3721500.0 3400600.0 7014200.0 False True 4817555.111732119 3211353.6206323532 5737687.5717696715 1.0 0.6665940598814931 1.1909957309666823 22.19986974004192 -6.7348885923411945 1.7051064433389114 0.800467221096084 1.190993371634095 0.581963576345585 0.1401099738458052 0.3271192100031474 1.8652604985085974 0.06505639812801674 0.16056577047955392 1.8412442672091628e-07 6.7348885923411945 0.390526150538011 VLWMQGSQQCK(ub)QTSEYLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLWMQGSQQCKQTSEYLR 18 1 Q9H3M7 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 25735100.0 6510200.0 6826900.0 12398000.0 True False 8534935.244866477 5808353.131047769 11115173.89001367 1.0 0.6805386291057486 1.302314964451445 23.024948776793426 -6.767047994842994 1.5856088116148217 0.8160705036009115 1.3054381991425497 0.7191452172694277 0.13454095699875063 0.2712566052813907 1.3454239817607057 0.0668977576491017 0.1596889427254101 1.709826347960433e-07 6.767047994842994 0.48936769554163817 VLWMQGSQQCK(ub)QTSEYLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLWMQGSQQCKQTSEYLR 18 1 Q9H3M7 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 82001000.0 10891000.0 28100000.0 43010000.0 True False 16522443.238751935 23085335.4536979 34509054.648047306 1.0 1.3972107587304812 2.0886169284642695 23.977923703741393 -6.9626671947218215 0.39605418114186486 0.9602982984918054 2.5506151024667627 0.9998566909277715 0.005384669657226778 0.07876174377530759 0.017709009649041464 0.008903729038175084 0.0580160976050548 1.0897648738560425e-07 6.9626671947218215 1.5903168039749573 up VLWMQGSQQCK(ub)QTSEYLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLWMQGSQQCKQTSEYLR 18 1 Q9H3M7 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 28298400.0 6510200.0 5688200.0 16100000.0 True False 8917196.871539831 5436876.515638013 12297511.589908293 1.0 0.6097069061007697 1.3790781752455292 23.088158838316318 -6.768790442590616 1.5790208721653967 0.775792748934411 1.3832153314942026 0.7259333336147212 0.16443862130644502 0.26839113755106453 1.3204597891006686 0.08209336255086075 0.19563891130635022 1.7029800385183742e-07 6.768790442590616 0.6074225825597916 VLWMQGSQQCK(ub)QTSEYLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLWMQGSQQCKQTSEYLR 18 1 Q9H3M7 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 113474000.0 10891000.0 24090000.0 78493000.0 True False 14098614.193705374 22749370.3231881 64208079.40619266 1.0 1.6135891095839079 4.554212103687448 23.749050025833842 -6.940755031073731 0.6525007356776187 0.9673737962524925 5.3651360867099145 0.9982611418193343 0.06468472555841008 0.08742384569666009 0.05305352453872123 0.06333196602518314 0.2522633844604215 1.1461592638005124e-07 6.940755031073731 4.397762290457422 VLYEK(ub)EQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLYEKEQK 8 1 Q10570;A0A087WTV4 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 1 2274410.0 482540.0 834960.0 956910.0 True False 632614.6129240076 710387.2226485884 857898.1325288739 1.0 1.122938370590442 1.3561149473983591 19.270967355852516 -6.961068801608522 0.42010116593520536 0.989704393833605 1.4981463659960448 0.9998078024279735 0.0020474554089208855 0.07932153787874689 0.01973693842954907 0.003016531520623046 0.019409621543247806 1.0937830737269938e-07 6.961068801608522 0.5084419721624398 VLYEK(ub)EQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLYEKEQK 8 1 Q10570;A0A087WTV4 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 1 2523740.0 423410.0 856630.0 1243700.0 True False 409969.081312916 1198686.8262664352 917937.6597997601 1.0 2.9238468970090863 2.2390411902772938 18.64515558436626 -10.239651646672645 5.4851996444376905 0.9998932442410189 2.5814440436432853 0.8767059049798034 0.2795707590734869 0.00036501041213819773 5.059715238838741e-05 0.2707109955859235 0.09023107449813318 5.759016904587993e-11 10.239651646672645 1.5815507994022664 VLYEK(ub)EQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLYEKEQK 8 1 Q10570;A0A087WTV4 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 1 2103030.0 482540.0 564190.0 1056300.0 True False 660948.0781531802 539262.220273164 806823.6951813746 1.0 0.8158919559611542 1.2207066210643955 19.334177417375408 -6.783094937012158 1.5241843136133844 0.8961705416111068 1.2242082593924246 0.7780565949323237 0.07796372075362898 0.2458024422505876 1.128121490411666 0.04028292243867974 0.09479302798454042 1.6478021416987718e-07 6.783094937012158 0.32803771778131785 VLYLFGGHHSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLYLFGGHHSR 11 0 G3V3U8;Q9Y2U9;G3V2H2;Q9Y2U9-2 G3V3U8 KLHDC2 Kelch domain-containing protein 2 0 4333400.0 1186700.0 0.0 3146700.0 False True 1149028.8580667388 0.0 2322484.8710234873 1.0 0.0 2.0212589568299517 20.13198360130903 -6.772185793681364 1.5661075938542113 0.4280257958165491 2.0335718232115316 0.7388350864175925 0.421707917145687 0.2629145057225632 1.2729281053870505 0.21220866324591697 0.5041343352742175 1.6897179059422484e-07 6.772185793681364 1.6055460273949826 VLYLFGGHHSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLYLFGGHHSR 11 0 G3V3U8;Q9Y2U9;G3V2H2;Q9Y2U9-2 G3V3U8 KLHDC2 Kelch domain-containing protein 2 0 4440400.0 1121500.0 1219400.0 2099500.0 False True 1536148.8573979167 1165522.8759834392 1603641.3405597787 1.0 0.7587304253558597 1.0439361607677706 20.550886593602122 -6.682510420654513 1.892923976564101 0.8476874643648894 1.0428724053505103 0.3355758226491209 0.10220088848142236 0.4330254127737141 3.0019762214345156 0.04328818372552987 0.11380563726542647 2.0772538824231706e-07 6.682510420654513 0.1951849409856209 VLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHR 33 0 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 447728000.0 121553000.0 155906000.0 170269000.0 False True 184404787.7146279 128083356.20086218 136615257.51844633 1.0 0.6945771733382278 0.7408444173904132 27.45830087214643 -10.144978086650429 5.198091755294159 1.0000101440623936 0.7177107953641606 0.9802504557080245 0.018888523289595324 2.220591828958249e-06 3.652891949509884e-07 0.01828939082860935 0.00609624467780366 7.161795458247222e-11 10.144978086650429 -0.28229934869823303 VLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHR 33 0 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 0 254930200.0 121553000.0 66685200.0 66692000.0 False True 157352754.66784206 62974109.99899801 54554740.317707345 1.0 0.40020977155392584 0.3467034335234082 27.22942719423888 -13.999999999999998 0.3420925036213153 8.026421257474187 0.33851833758713085 0.9997393583131312 0.004781355475320023 19.897434976684032 0.1877483105967765 101.20660478439169 0.01640901214715745 1.0000000000000041e-14 13.999999999999998 -7.687902919887056 VLYSQK(ub)ATPGSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLYSQKATPGSSR 13 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 7508010.0 721510.0 1295100.0 5491400.0 True False 698606.0599846063 1812240.1838572796 4053037.601531243 1.0 2.5940802516044763 5.801606704672088 19.414119631729882 -6.959926207870048 0.43647262572729667 0.8810020958882289 7.639012077022113 0.9997674526192531 0.030450147050550214 0.0797274892682696 0.0212288008191207 0.04211151911534837 0.2659481757458724 1.0966645174971087e-07 6.959926207870048 6.758009981133885 VLYSQK(ub)ATPGSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLYSQKATPGSSR 13 1 Q12834 Q12834 CDC20 Cell division cycle protein 20 homolog 1 5715520.0 721510.0 2581500.0 2412510.0 True False 599967.5333125559 2567592.9471123707 2916954.6868140795 1.0 4.279553150044823 4.86185422519268 19.19452490716416 -9.730081541808133 0.4598430900510412 2.62479869397737e-13 4.87907497447334 0.998712965457666 0.06098614414209024 1.0315857534226363 0.20117796542080882 1.7255220831560398 0.1274938187810768 1.861737549677706e-10 9.730081541808133 4.8790749744730775 VLYTCFQSIQAQK(ub)SSESLHGPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLYTCFQSIQAQKSSESLHGPR 22 1 H9KVA9;A0A0D9SF50;P46736;P46736-4;X6RJS7 H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 29517200.0 4341200.0 11283000.0 13893000.0 True False 6585917.784231926 9269460.495518638 11147042.460481782 1.0 1.4074667797572082 1.6925571842348455 22.65095307138479 -7.221234818753371 0.08176554832057277 8.912788519178727e-13 3.0370094802233822 0.9999997148456831 0.00015165399673063042 0.09677168704091652 0.0037775133567054904 0.05564525827889272 0.08266821490177363 6.00848776617817e-08 7.221234818753371 3.037009480222491 VLYTCFQSIQAQK(ub)SSESLHGPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLYTCFQSIQAQKSSESLHGPR 22 1 H9KVA9;A0A0D9SF50;P46736;P46736-4;X6RJS7 H9KVA9 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 29471200.0 4341200.0 13712000.0 11418000.0 True False 5619768.977845357 12948915.146183277 9340041.15857348 1.0 2.304172146084899 1.6619973517406923 22.42207939347724 -10.101570336615685 5.7074945224027305 0.9999926749842215 1.9830847489129106 0.7575605849525426 0.26216676197041155 2.4436633172531036e-05 3.846221894704779e-06 0.2538437646334783 0.08461395858665158 7.914612623097332e-11 10.101570336615685 0.9830920739286891 VLYTCFQSIQAQK(ub)SSEYER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLYTCFQSIQAQKSSEYER 19 1 A0A087WZR3;P46736-2;P46736-3 A0A087WZR3 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 35851800.0 13197000.0 9935800.0 12719000.0 True False 17301394.799929794 8453417.36944506 11402959.889263093 1.0 0.4885974493501161 0.6590774917932839 24.04438501362424 -10.351877031553245 6.334496076089945 1.0000334228023753 0.5738374705717003 0.8928402716473502 0.06959818588563028 3.285400162244038e-05 3.361525763547081e-06 0.06739342269558031 0.022462717905107805 4.447571805532502e-11 10.351877031553245 -0.42619595223067497 VLYTCFQSIQAQK(ub)SSEYER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLYTCFQSIQAQKSSEYER 19 1 A0A087WZR3;P46736-2;P46736-3 A0A087WZR3 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 19857700.0 7906300.0 5085800.0 6865600.0 True False 7655318.83418981 7116586.462096636 5067293.396414917 1.0 0.9296263965274557 0.6619310712159524 22.868031034694642 -6.946030954820534 0.6008472557399614 1.0030096771205648 0.5748245648935899 0.9988517899407701 0.004935105542510366 0.08511989850117188 0.04286889839225679 0.0050608814634022555 0.022502629330136633 1.1323196530209967e-07 6.946030954820534 -0.42818511222697486 VLYTCFQSIQAQK(ub)SSEYER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLYTCFQSIQAQKSSEYER 19 1 A0A087WZR3;P46736-2;P46736-3 A0A087WZR3 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 236142000.0 19132000.0 105460000.0 111550000.0 True False 29024642.736553315 86639839.0372591 89502093.60589808 1.0 2.9850441166032287 3.083658752263646 24.79077497332219 -10.465710466803733 0.5919983197111571 6.176168859045558e-19 3.0726310302153967 0.9997964611646111 0.013693853555988697 1.8522933666994361 0.2874060557521177 2.8858214570331397 0.017302989215124315 3.4220750761173725e-11 10.465710466803733 3.0726310302153967 VLYTCFQSIQAQK(ub)SSEYER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLYTCFQSIQAQKSSEYER 19 1 A0A087WZR3;P46736-2;P46736-3 A0A087WZR3 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 40723700.0 13197000.0 8802700.0 18724000.0 True False 18076287.53551522 8413767.607363803 14301776.83288465 1.0 0.465458827805927 0.7911899390173656 24.10759507514713 -10.334218773490274 6.218288800633904 1.0000269242817188 0.6283243834116528 0.6345022161067575 0.1329791693029647 4.963984184563517e-05 5.315147826366426e-06 0.12876583455231874 0.04291884234190651 4.63213519655484e-11 10.334218773490274 -0.37170254087006604 VLYTCFQSIQAQK(ub)SSEYER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLYTCFQSIQAQKSSEYER 19 1 A0A087WZR3;P46736-2;P46736-3 A0A087WZR3 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 27339800.0 7906300.0 2425500.0 17008000.0 True False 6574438.75847744 2412433.350075945 20564294.16389314 1.0 0.36694133730658324 3.127916301201592 22.64843631012892 -6.846384883659156 1.2522860386312775 0.6629234348030925 3.2308961704720627 0.934888203561409 0.30134301989541185 0.16148568099933683 0.48913309369336555 0.18844958657047042 0.4352257705402452 1.4243447407951664e-07 6.846384883659156 2.5679727356689703 up VLYTCFQSIQAQK(ub)SSEYER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLYTCFQSIQAQKSSEYER 19 1 A0A087WZR3;P46736-2;P46736-3 A0A087WZR3 BRCC3 Lys-63-specific deubiquitinase BRCC36 1 217539000.0 19132000.0 108540000.0 89867000.0 True False 24766751.148101307 102499653.58567177 73512128.11328806 1.0 4.138599082808231 2.9681780897985774 24.56190129541464 -9.430323877828611 10.196460438118347 1.0000000015021695 3.5533885861640853 0.8638683234760524 0.4778223695192106 0.0 0.0 0.46264951989831604 0.15421650663277198 3.712582576636482e-10 9.430323877828611 2.5533885846619158 VLYVYDMLAGK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 VLYVYDMLAGK 11 0 Q9Y5J1;J3KSR7 Q9Y5J1 UTP18 U3 small nucleolar RNA-associated protein 18 homolog 1 5600700.0 1731800.0 2527600.0 1341300.0 True False 2270406.5707750577 2150491.932507633 1202515.1426581168 1.0 0.9471836278968798 0.5296474905142692 21.11451923913957 -6.93031870258638 0.7441792093756622 1.0062752276199802 0.4432319210375158 0.9966003237001293 0.012266875809284143 0.09247303127696353 0.07687424987379804 0.011196893342630387 0.037713950557664765 1.174035684600078e-07 6.93031870258638 -0.5630433065824645 VLYVYDMLAGK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VLYVYDMLAGK 11 0 Q9Y5J1;J3KSR7 Q9Y5J1 UTP18 U3 small nucleolar RNA-associated protein 18 homolog 1 7117400.0 1731800.0 3758300.0 1627300.0 True False 2372093.260135279 3592245.8789638863 1242965.2552955134 1.0 1.5143780134340177 0.5239951043175376 21.177729300662463 -6.765548224513801 1.5914310868913677 1.2967068146159042 0.5193291891330765 0.7132680440892076 0.21655798216468358 0.27368933739825124 1.367233953009474 0.10730383847265249 0.256491560941909 1.7157411818464416e-07 6.765548224513801 -0.7773776254828277 VLYVYDMLAGK(ub)LIPVHQVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VLYVYDMLAGKLIPVHQVR 19 1 Q9Y5J1;J3KSR7 Q9Y5J1 UTP18 U3 small nucleolar RNA-associated protein 18 homolog 1 20985400.0 9383100.0 6509600.0 5092700.0 True False 9085238.626549274 9108917.227115557 3758769.0922748633 1.0 1.0026062717270945 0.4137226601061228 23.115092977104215 -6.905903526786826 0.923185065108223 1.0206782659201619 0.34392956238861216 0.9892815495173198 0.028676774290111656 0.10718952887291916 0.15392450184132805 0.023012529576630966 0.06185850482202756 1.2419281561197455e-07 6.905903526786826 -0.6767487035315497 down VLYVYDMLAGK(ub)LIPVHQVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VLYVYDMLAGKLIPVHQVR 19 1 Q9Y5J1;J3KSR7 Q9Y5J1 UTP18 U3 small nucleolar RNA-associated protein 18 homolog 1 92583100.0 26990400.0 41222700.0 24370000.0 True False 40946410.06254801 33866187.110574804 19553258.818249553 1.0 0.827085623839605 0.4775329214058282 25.287233634710482 -6.959835171455474 0.43775604204251006 1.012794998054408 0.2782457760010061 0.9997640222025955 0.0033383965968582256 0.07976013451159802 0.02134977835514982 0.00459612644619081 0.028975224894093415 1.0968944234120197e-07 6.959835171455474 -0.7345492220534019 down VLYVYDMLAGK(ub)LIPVHQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VLYVYDMLAGKLIPVHQVR 19 1 Q9Y5J1;J3KSR7 Q9Y5J1 UTP18 U3 small nucleolar RNA-associated protein 18 homolog 1 20508800.0 9383100.0 7648400.0 3477300.0 True False 7802463.391810298 7607196.551111457 4204387.35278137 1.0 0.9749736934486871 0.5388538390573447 22.89549825253849 -6.918699279451005 0.8343167526861472 1.0100812816762004 0.470587442099459 0.9938118936611103 0.016655973543975303 0.09894328502622349 0.10962463920686644 0.014252833276879711 0.042177312483681534 1.205870637968771e-07 6.918699279451005 -0.5394938395767414 VLYVYDMLAGK(ub)LIPVHQVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VLYVYDMLAGKLIPVHQVR 19 1 Q9Y5J1;J3KSR7 Q9Y5J1 UTP18 U3 small nucleolar RNA-associated protein 18 homolog 1 62873400.0 26990400.0 23192000.0 12691000.0 True False 34939604.86032372 21901344.812593512 10381368.2206565 1.0 0.6268343588929355 0.2971232291308836 25.05835995680293 -7.588754803528107 0.27001609120047126 1.1192648569206467 1.3146822251531034e-12 0.9997597855470619 0.0044501971346172665 0.12820505276570776 0.031240039109904274 0.030396963044246994 0.07155207526566662 2.5777761218797108e-08 7.588754803528107 -1.119264856919332 down VMAAIEK(ub)VR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMAAIEKVR 9 1 F8WE18;F8WDZ4;Q9BQE9-4;Q9BQE9-3;Q9BQE9;Q4VC05;Q4VC05-2 F8WE18 BCL7B;BCL7A B-cell CLL/lymphoma 7 protein family member B;B-cell CLL/lymphoma 7 protein family member A 1 3554000.0 1025800.0 1386000.0 1142200.0 True False 993236.5404945313 1939437.0278945146 843023.5547344917 1.0 1.952643654178159 0.8487641366020942 19.921777812693946 -6.67840784544382 1.907492331177767 1.6036214113087528 0.8530209361732852 0.31678481812963055 0.4038972329710897 0.4421262309366146 3.1088304719358466 0.16998802262464083 0.4492571010138921 2.0969696968601386e-07 6.67840784544382 -0.7506004751354676 VMALELGPHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMALELGPHK 10 0 J3QS36;Q7Z4W1;J3KS22;J3QL34;J3KSZ5;J3QS45 J3QS36 DCXR L-xylulose reductase 0 5777700.0 1059700.0 1922500.0 2795500.0 False True 1451499.727315714 1837557.5931426608 2135260.475129728 1.0 1.2659717108875321 1.4710719092441762 20.46911287025857 -6.974023130448821 0.13009848422444892 0.6827731402384416 2.059579128644014 0.9999992171542338 0.000170532120209878 0.07501754121368494 0.003906034915976198 0.012890344597532518 0.02800684895496215 1.0616390129831736e-07 6.974023130448821 1.3768059884055723 VMDQHK(ub)LTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VMDQHKLTR 9 1 P15311;E7EQR4 P15311 EZR Ezrin 1 6325800.0 3291900.0 2175100.0 858800.0 True False 4315712.778804942 1850583.5584733947 769939.6141912993 1.0 0.42880137148187075 0.17840381268479646 22.04116742247675 -9.719993683782302 0.22590864913374195 1.513140879001194 1.5003388968977893e-23 0.999260948720849 0.00934725587584823 1.1521402218239116 0.09595574784460197 0.5153441000487917 0.12401864812493998 1.905488430477979e-10 9.719993683782302 -1.513140879001194 VMDQHK(ub)LTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMDQHKLTR 9 1 P15311;E7EQR4 P15311 EZR Ezrin 1 8973400.0 4426900.0 3307900.0 1238600.0 True False 4286370.482662543 4628761.720470614 914173.5027964814 1.0 1.0798790583298785 0.21327449563543768 22.03132512078531 -6.884356057071903 1.0551732213818936 1.053056192100019 0.14648025038051526 0.9770339331011562 0.05926277015783616 0.12384289082456791 0.2495448273169753 0.04307949097816543 0.1054344780690686 1.3051004605567487e-07 6.884356057071903 -0.9065759417195037 down VMDQHK(ub)LTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VMDQHKLTR 9 1 P15311;E7EQR4 P15311 EZR Ezrin 1 17546000.0 5065800.0 4138000.0 8342200.0 True False 7685188.959587698 3399541.569658435 6693360.513483853 1.0 0.4423497701272939 0.8709428679868068 22.873649301941413 -9.862825317495874 6.477842783834553 1.0000000147673613 0.6566463190570252 0.46112567139087035 0.1749723995058774 3.737032318714721e-08 6.625121585208219e-09 0.16941630490649084 0.05647209911100012 1.3714332749589883e-10 9.862825317495874 -0.34335369571033614 VMDQHK(ub)LTR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VMDQHKLTR 9 1 P15311;E7EQR4 P15311 EZR Ezrin 1 23919600.0 9658100.0 8791500.0 5470000.0 True False 13228960.570338683 8403062.46039724 4178098.6581862257 1.0 0.6352020187616378 0.31582970075170913 23.657196374435163 -7.556714512584829 0.25726572704421197 1.129507227128144 8.668154630563233e-14 0.9998223891616942 0.0037251318892396294 0.12830638844074577 0.027910801187237985 0.02957953705189013 0.06942213387371556 2.7751437711028574e-08 7.556714512584829 -1.1295072271280575 down VMDQHK(ub)LTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VMDQHKLTR 9 1 P15311;E7EQR4 P15311 EZR Ezrin 1 11204610.0 4426900.0 6016400.0 761310.0 True False 3681163.494922248 5983988.4590380965 920496.4011002755 1.0 1.6255698686820992 0.25005583217642924 21.811730396219588 -6.783036948391452 1.5238531171360585 1.3528135509663926 0.2380643460419308 0.7780565641054742 0.26491194076130586 0.24587891817354207 1.1278914964418334 0.13689174980209076 0.32222206013699073 1.6480221770826138e-07 6.783036948391452 -1.1147492049244618 VMDQHK(ub)LTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VMDQHKLTR 9 1 P15311;E7EQR4 P15311 EZR Ezrin 1 13655800.0 5065800.0 4558600.0 4031400.0 True False 6557777.96184673 4304909.902668548 3297726.5656571332 1.0 0.6564586248138609 0.5028725560461739 22.644775624033862 -13.999999999974001 0.10889318359270843 2.6609421810478713 0.21658165190479778 0.9997486867014242 0.003294718020783848 12.019259176159197 0.09995263268196812 4.398283833618406 0.25436080920565796 1.0000000000598643e-14 13.999999999974001 -2.4443605291430734 VMEHFIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VMEHFIK 7 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 18626500.0 1521100.0 9201000.0 7904400.0 False True 1994176.8303533536 7828246.665217101 7086528.512358777 1.0 3.9255529128928814 3.553610895731396 20.927361913344484 -10.361848929006177 5.778758382845261 0.9994377060572764 3.739581904312146 0.9863642046819431 0.1518446926578824 0.0011001807536663282 0.00012149242333564796 0.14704483363517715 0.0490076638228265 4.346613965035784e-11 10.361848929006177 2.7401441982548693 VMEHFIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMEHFIK 7 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 17411400.0 1521100.0 8328500.0 7561800.0 False True 2083491.7761818746 7960519.331333497 5775858.580159527 1.0 3.82075870053187 2.7722012854517426 20.990571974867375 -10.329203401026552 6.0482252941237 0.9997986722476299 3.296479992991756 0.8647840204223476 0.4280717721596769 0.0011622900597509675 0.00012890643280950566 0.41451174384494194 0.13815957037965912 4.6859386566398174e-11 10.329203401026552 2.2966813207441263 VMELHK(ub)SYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMELHKSYR 9 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6 P11171 EPB41 Protein 4.1 1 3392100.0 1285000.0 1169500.0 937600.0 True False 1244208.3783734366 1636487.44886193 692014.4326029232 1.0 1.31528406118059 0.5561885329108611 20.24679669568523 -6.793918477809258 1.4807489622844119 1.1753220168893437 0.5472349282586191 0.8137211087357631 0.13439027499658004 0.22957050615147548 0.9942834058864799 0.0714235271268016 0.1667476006919888 1.607242923130318e-07 6.793918477809258 -0.6280870886307246 VMELHK(ub)SYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VMELHKSYR 9 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6 P11171 EPB41 Protein 4.1 1 8050700.0 2437400.0 2252500.0 3360800.0 True False 3697713.99780865 1850523.7761371706 2696536.40690903 1.0 0.500450758829329 0.7292441785673687 21.818202212157228 -10.352841376533204 5.880574727407592 1.000060251534305 0.6148474686983488 0.7907284556246054 0.09340452247743807 7.379468867344435e-05 8.121038611277838e-06 0.09045262672314344 0.03014618000129749 4.4377069893331326e-11 10.352841376533204 -0.38521278283595606 VMELHK(ub)SYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMELHKSYR 9 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6 P11171 EPB41 Protein 4.1 1 2937370.0 1439700.0 865470.0 632200.0 True False 1971995.9964295875 827230.6736734352 482887.38056770345 1.0 0.419489022884014 0.24487239398152882 20.91122519206584 -13.999999999999998 0.16833220421985212 3.9149722719340376 0.08807355894311143 0.9995169602371429 0.007094182977601537 12.075737258118675 0.1298890783882082 11.492548400351764 0.14455398450175008 1.0000000000000041e-14 13.999999999999998 -3.826898712990926 VMELHK(ub)SYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VMELHKSYR 9 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6 P11171 EPB41 Protein 4.1 1 4557420.0 1285000.0 2543300.0 729120.0 True False 1068534.4351521581 2529598.7380944733 881575.6209300199 1.0 2.367353502963394 0.8250324855506266 20.027201971119506 -6.672727151414913 1.9274070814816726 1.8706960929301977 0.8311415269799067 0.29134562889924576 0.5804546688893233 0.4548649061876879 3.2601939871913115 0.24220944791913704 0.6449006656342546 2.124578824493405e-07 6.672727151414913 -1.039554565950291 VMELHK(ub)SYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VMELHKSYR 9 1 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A0A2R8Y4N6 P11171 EPB41 Protein 4.1 1 9081200.0 2437400.0 3348900.0 3294900.0 True False 3155262.348336931 3162530.771080306 2695262.0085289665 1.0 1.0023035874488238 0.854211698101611 21.589328534249677 -6.903367497598671 0.9397283949952525 1.005601238861094 0.8375583286458451 0.9881686103276613 0.0075351488690027744 0.10896896803532305 0.1637678733925943 0.005973587289578468 0.015822118162860638 1.2492015154069695e-07 6.903367497598671 -0.16804291021524886 VMETK(ub)PDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VMETKPDK 8 1 Q92890;Q92890-1;C9IZG3;Q92890-3;C9JNP9 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 1 4938800.0 1616500.0 1937000.0 1385300.0 True False 2119247.1542082704 1648007.1503668642 1241962.4447359194 1.0 0.7776380150348925 0.5860394538077859 21.015120419119047 -6.972861848377816 0.17694121167141916 1.1542579147051326 0.20425402671793963 0.9999969596233216 0.0002948921299450708 0.0753845868774961 0.005561111393788813 0.007581818151433079 0.02170541739197566 1.0644815822072176e-07 6.972861848377816 -0.950003887987193 VMETK(ub)PDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMETKPDK 8 1 Q92890;Q92890-1;C9IZG3;Q92890-3;C9JNP9 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 1 4556800.0 1616500.0 1372100.0 1568200.0 True False 2214163.7342699394 1311476.0850720638 1197823.4580928048 1.0 0.5923121514337726 0.5409823309601604 21.078330480641938 -13.999999999999998 0.2922046327632356 4.557048999132643 0.5273029039970504 0.9996323971081025 0.003937288957377467 16.09823743451868 0.17147222040394527 34.465892124975774 0.01919502956681521 1.0000000000000041e-14 13.999999999999998 -4.029746095135593 VMETK(ub)PDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VMETKPDK 8 1 Q92890;Q92890-1;C9IZG3;Q92890-3;C9JNP9 Q92890 UFD1L Ubiquitin fusion degradation protein 1 homolog 1 3382000.0 1421500.0 1379200.0 581300.0 True False 1182040.2331274676 1371769.975850234 702847.1423724766 1.0 1.1605103933059668 0.5946050926818865 20.172847710715796 -6.830950204090786 1.3238694125883865 1.08570776403775 0.5791019062103177 0.9077221055387799 0.07233771758522796 0.17964335230608713 0.6154588477080529 0.04290018396666069 0.09871253522034751 1.4758757464816854e-07 6.830950204090786 -0.5066058578274323 VMETQAQVDELK(ub)GIMVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VMETQAQVDELKGIMVR 17 1 P51809-3;P51809;P51809-2 P51809-3 VAMP7 Vesicle-associated membrane protein 7 1 6194300.0 2313000.0 1858300.0 2023000.0 True False 3032365.39912386 1581048.8835966657 1813679.3659862585 1.0 0.5213912822160144 0.598107130001643 21.53201217762915 -10.718550972922163 6.855496071693639 1.0051787797635516 0.5597492061088813 0.9777335151019627 0.031319113709968795 0.0024915078431394623 0.00010228756058078491 0.03047752570961318 0.0101082004847238 1.911828921048921e-11 10.718550972922163 -0.4454295736546703 VMFEK(ub)IAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMFEKIAK 8 1 Q9Y221;Q9Y221-2;J3QLW7 Q9Y221 NIP7 60S ribosome subunit biogenesis protein NIP7 homolog 1 17006300.0 5440200.0 2866500.0 8699600.0 True False 5267503.82881492 4011108.3986000214 6420913.777594284 1.0 0.7614818192742421 1.2189670831314532 22.328688027025567 -6.765035915701556 1.5935352491351267 0.8623237188031417 1.2210656233067763 0.7111549069574594 0.10040749619309787 0.2745490876333821 1.3750905397272764 0.04968980004874924 0.11882532624883914 1.7177663237966288e-07 6.765035915701556 0.3587419045036345 VMFEK(ub)IAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VMFEKIAK 8 1 Q9Y221;Q9Y221-2;J3QLW7 Q9Y221 NIP7 60S ribosome subunit biogenesis protein NIP7 homolog 1 34106200.0 6113200.0 12148000.0 15845000.0 True False 9274171.334784536 9980094.487242794 12713228.804889793 1.0 1.076117113537741 1.3708209980126655 23.14478694921331 -6.945624649385098 0.6049830867498288 0.9967136051013584 1.4654399631360606 0.9988115814277461 0.005512784085515059 0.08529185045300294 0.04361176511825502 0.005630562643400537 0.024807154022935235 1.1333794935779697e-07 6.945624649385098 0.4687263580347022 VMFEK(ub)IAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VMFEKIAK 8 1 Q9Y221;Q9Y221-2;J3QLW7 Q9Y221 NIP7 60S ribosome subunit biogenesis protein NIP7 homolog 1 14189200.0 5440200.0 4664700.0 4084300.0 True False 4523767.3417235585 4639570.335229545 4938308.246330478 1.0 1.0255987951541878 1.0916362123187748 22.109093302459843 -6.954785844753793 0.5035746742103148 0.9987174768110088 1.1213831350742562 0.9995252643291959 0.000841132557864061 0.0816190716459354 0.028435886465539184 0.000979924596824178 0.005448257158170022 1.1097218960816343e-07 6.954785844753793 0.12266565826324749 VMFEK(ub)IAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VMFEKIAK 8 1 Q9Y221;Q9Y221-2;J3QLW7 Q9Y221 NIP7 60S ribosome subunit biogenesis protein NIP7 homolog 1 26488100.0 6113200.0 7491900.0 12883000.0 True False 7913657.909187377 7074969.179090608 10538426.190742876 1.0 0.8940200928924295 1.33167573221838 22.915913271305758 -6.842728392371908 1.2695765371903132 0.9436225823044105 1.3468729738361132 0.92904939428223 0.04965675781327788 0.16564362306046537 0.5174304163302026 0.030653764584238914 0.07068407757700311 1.4363874687658414e-07 6.842728392371908 0.4032503915317026 VMIHVFSDGVTNWGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMIHVFSDGVTNWGR 15 0 Q07820;A0A087WT64 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 0 6252500.0 2939700.0 1007900.0 2304900.0 False True 2846380.8326104283 1410359.7261290639 1701177.5444821636 1.0 0.49549227916758304 0.5976633642947934 21.44069727003662 -9.994134026941225 5.986729083209066 1.0000004311770962 0.5465778217311916 0.9633156863628682 0.041711170838234786 2.400220111175266e-07 4.0410608902525726e-08 0.040386705414203874 0.01346222250057675 1.013598532405819e-10 9.994134026941225 -0.4534226094459046 VMIHVFSDGVTNWGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VMIHVFSDGVTNWGR 15 0 Q07820;A0A087WT64 Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 0 10529600.0 3429400.0 7100200.0 0.0 False True 5202650.522722973 5833113.835884195 0.0 1.0 1.1211811768650664 0.0 22.31081536984116 -6.949523423760752 1.2047601574686941 1.0681523047917925 4.495688182579807e-19 0.9717067189159969 0.08450822104354204 0.10785639103232243 0.31119388599047193 0.058306961526243165 0.11085424713158461 1.123250385303726e-07 6.949523423760752 -1.0681523047917925 down VMK(ub)GVDDLDFFIGDEAIEKPTYATK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMKGVDDLDFFIGDEAIEKPTYATK 25 2 P61158 P61158 ACTR3 Actin-related protein 3 1 19642300.0 8217000.0 6606800.0 4818500.0 True False 7956155.832758395 9244929.694006838 3556390.2980985343 1.0 1.1619844920510596 0.4469985722823048 22.923640103030525 -6.84717690537149 1.2487070593815806 1.0862728333592997 0.41994627233619813 0.9360854370701568 0.0773852106343493 0.1605907225995945 0.4832971172944298 0.04852765114797563 0.11210733079209413 1.4217495341666086e-07 6.84717690537149 -0.6663265610231015 down VMK(ub)QSEENNNLQSQVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VMKQSEENNNLQSQVQK 17 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7;B4DSP0;A0A087WZG9;Q86TG7-2 A0A087WUL4;B4DSP0 PEG10 Retrotransposon-derived protein PEG10 1 6708450.0 3046800.0 3133100.0 528550.0 True False 3994384.3052531676 2665653.692728148 473860.71620960865 1.0 0.6673503321206337 0.11863172894666552 21.929541712474258 -7.41250850260892 0.53405147169344 1.0080695963912902 2.4246572180036218e-21 0.9970118191111745 0.01986517279393976 0.11037438382584203 0.06807746920901404 0.020615640826968887 0.06494794999603973 3.868044817083016e-08 7.41250850260892 -1.0080695963912902 down VMK(ub)QSEENNNLQSQVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMKQSEENNNLQSQVQK 17 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7;B4DSP0;A0A087WZG9;Q86TG7-2 A0A087WUL4;B4DSP0 PEG10 Retrotransposon-derived protein PEG10 1 44109900.0 15291000.0 24506000.0 4312900.0 True False 14805595.574870238 34291373.59710178 3183222.1057734126 1.0 2.3161090294337803 0.21500128716039926 23.819639190230525 -6.7373495181391245 1.6963611406322099 1.7854680150523434 0.21445678118357092 0.5930134313866622 0.5530177997397385 0.3226272633660548 1.8218708298454804 0.25800870479665955 0.6349912092808865 1.8308403776466384e-07 6.7373495181391245 -1.5710112338687725 VMK(ub)QSEENNNLQSQVQK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VMKQSEENNNLQSQVQK 17 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7;B4DSP0;A0A087WZG9;Q86TG7-2 A0A087WUL4;B4DSP0 PEG10 Retrotransposon-derived protein PEG10 1 70515100.0 24872400.0 24089400.0 21553300.0 True False 37733249.216007166 19790458.358658746 17293280.80785304 1.0 0.5244832811870136 0.45830351658443713 25.169333000404837 -13.999999999999998 0.27783097898320325 4.829501248460396 0.4379509661620649 0.9996003879060885 0.004823194660546972 15.282134764647815 0.1669426604911269 33.20999166203525 0.026451388043800907 1.0000000000000041e-14 13.999999999999998 -4.391550282298331 VMK(ub)QSEENNNLQSQVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VMKQSEENNNLQSQVQK 17 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7;B4DSP0;A0A087WZG9;Q86TG7-2 A0A087WUL4;B4DSP0 PEG10 Retrotransposon-derived protein PEG10 1 45964600.0 15291000.0 28677000.0 1996600.0 True False 12715144.006156947 28522511.30906116 2414079.828764643 1.0 2.2431921569468614 0.18985863059008168 23.6000444656648 -6.742816027380959 1.6764690941705778 1.737291438209512 0.18793590620976147 0.6174311405286914 0.5223174939494626 0.31277271129350465 1.7270985982051392 0.2463711580141327 0.6026946274425975 1.8079398299288597e-07 6.742816027380959 -1.5493555319997505 VMK(ub)QSEENNNLQSQVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VMKQSEENNNLQSQVQK 17 1 A0A087WUL4;A0A087WX23;A0A087WXK2;Q86TG7;B4DSP0;A0A087WZG9;Q86TG7-2 A0A087WUL4;B4DSP0 PEG10 Retrotransposon-derived protein PEG10 1 94177200.0 24872400.0 53925900.0 15378900.0 True False 32197812.108302075 50924876.260324165 12580098.000839526 1.0 1.5816253628982881 0.3907128210613975 24.940459322497286 -6.773888313655192 1.559390757443757 1.331946913713179 0.3829777656588352 0.745265136659204 0.24540730432555036 0.2601909096065896 1.2491345713800879 0.12400254243228934 0.29415908780036865 1.6831068454834292e-07 6.773888313655192 -0.9489691480543438 down VMLGETNPADSK(ub)PGTIR ddPTM_RPMI8226_Bortezomib_1h_R1 2 VMLGETNPADSKPGTIR 17 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 1 166621600.0 40759000.0 64999000.0 60863600.0 True False 53435443.71071741 55301402.56411756 54566018.516876645 1.0 1.03491987197677 1.021157769593527 25.671293662738513 -10.021571057266415 4.513645699558034 0.9999989248275835 1.0280388207876747 0.8469690293365022 0.005618354779738647 6.079129597307087e-08 1.3183077935300726e-08 0.005440157280300863 0.0018133162067105384 9.515441480971413e-11 10.021571057266415 0.028039895960091266 VMLGETNPADSK(ub)PGTIR ddPTM_RPMI8226_Bortezomib_2h_R1 2 VMLGETNPADSKPGTIR 17 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 1 184574800.0 63566700.0 57232100.0 63776000.0 True False 61548809.90315234 80085175.99145862 47071152.361011125 1.0 1.301165304698392 0.7647776201534693 25.875227625496095 -6.754337282549578 1.633600818177628 1.1761595927057538 0.7633361940688704 0.6674895700633774 0.12658931458673042 0.29254347515025064 1.5372205730877826 0.06117952731567114 0.14786862144131002 1.7606081886771827e-07 6.754337282549578 -0.41282339863688333 VMLGETNPADSK(ub)PGTIR ddPTM_RPMI8226_Bortezomib_8h_R1 2 VMLGETNPADSKPGTIR 17 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 1 438862700.0 130677200.0 117295200.0 190890300.0 True False 198246866.18299848 96362955.12841953 153160748.5348094 1.0 0.4860755530908037 0.7725758872446902 27.562722819590668 -10.143103018727638 5.462035729001773 1.0000077373193927 0.6293257201676649 0.6905838180530656 0.11696327163594768 1.1020548064596246e-05 1.7290061769346287e-06 0.113251562288243 0.03774973359695346 7.192783381924495e-11 10.143103018727638 -0.3706820171517279 VMLGETNPADSK(ub)PGTIR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VMLGETNPADSKPGTIR 17 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 1 158974700.0 40759000.0 57450400.0 60765300.0 True False 55828703.77055876 54912051.36493265 46413787.64063689 1.0 0.9835809835493707 0.831360653318861 25.734503724261405 -6.927460856534305 0.7673451194591602 1.002545850862237 0.8020393702037459 0.996015286620186 0.004792656453065742 0.09397788782902526 0.08429676469475451 0.004302119009369404 0.013970556216610253 1.1817868235627179e-07 6.927460856534305 -0.20050648065849097 VMLGETNPADSK(ub)PGTIR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VMLGETNPADSKPGTIR 17 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 1 197665300.0 63566700.0 95825600.0 38273000.0 True False 52858527.53228537 95309368.47290775 46275707.34564212 1.0 1.803102979262786 0.8754634210606314 25.65563290093037 -6.6777440242409165 1.9097827056484555 1.5091690495141585 0.8790492457328781 0.31377829782053923 0.34054571520934823 0.4436169536726395 3.126201848286643 0.143181698160411 0.3787436818467513 2.1001773759722384e-07 6.6777440242409165 -0.6301198037812804 VMLGETNPADSK(ub)PGTIR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VMLGETNPADSKPGTIR 17 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 1 422297100.0 130677200.0 140503300.0 151116600.0 True False 169164211.43271303 132684167.84267303 123614929.38725567 1.0 0.7843512922675707 0.7307392523531782 27.333849141683118 -13.999999999999998 0.19547272388008569 2.17870635536658 0.6943257633718077 0.9994873166126956 0.0026349263971708788 12.445076721408386 0.14020464641806327 5.598265835134043 0.03532688761004154 1.0000000000000041e-14 13.999999999999998 -1.4843805919947726 VMLGETNPADSKPGTIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VMLGETNPADSKPGTIR 17 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 0 31445800.0 1742500.0 27490400.0 2212900.0 False True 2284434.3743940024 23388939.476739887 1983930.3356356856 1.0 10.238394124560628 0.8684558234079137 21.123405567748744 -6.649436205066691 2.010937767353307 6.997527772640989 0.9081027182149789 0.1916874443707064 3.9436050785058123 0.509859755233899 3.951516185094011 1.5909581516151943 4.366893114871945 2.2416293018403287e-07 6.649436205066691 -6.089425054426011 VMLGETNPADSKPGTIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMLGETNPADSKPGTIR 17 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 0 23383700.0 15383400.0 4716900.0 3283400.0 False True 14895062.387447434 6600382.768308542 2423379.040111388 1.0 0.44312555373187995 0.16269680361685834 23.828330830489314 -9.001099543150648 0.26573882990166603 1.2934803819247975 5.009213210382696e-16 0.9990038812521813 0.0109827940481516 0.46650828302693864 0.09032907871737644 0.23619367245029627 0.10692865759978838 9.974714106136656e-10 9.001099543150648 -1.293480381924797 VMLGETNPADSKPGTIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMLGETNPADSKPGTIR 17 1 Q32Q12;P22392-2;J3KPD9;P22392;E7ERL0;O60361;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase;Nucleoside diphosphate kinase A 0 51094200.0 1742500.0 25237900.0 24113800.0 False True 2386749.3392919037 24122806.12742531 18418617.07930002 1.0 10.10697090402548 7.717030345869676 21.186615629271635 -10.068687900683052 9.079942469354952 0.9999999758379643 8.912000624947579 0.9359505036771726 0.9756891471773577 5.42470431348133e-07 6.201462463314813e-08 0.9447069545229909 0.3149023181744353 8.537134021571203e-11 10.068687900683052 7.912000649109615 VMMVALGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VMMVALGR 8 0 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 0 15106800.0 5982900.0 6987400.0 2136500.0 False True 7843639.838486007 5944907.15667187 1915435.4747551386 1.0 0.7579270949568951 0.2442023746879305 22.903091861208207 -7.023399862974754 0.46989416026845493 1.0137025453174175 4.853861556731857e-11 0.9996977763025677 0.005478339588649055 0.07392670204336278 0.02389973847630615 0.007030253611416349 0.03894236330550229 9.475456387269064e-08 7.023399862974754 -1.013702545268879 down VMMVALGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMMVALGR 8 0 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 0 6412500.0 2784500.0 1128500.0 2499500.0 False True 2696107.571658243 1579115.935049756 1844805.9666073024 1.0 0.5857021254083418 0.6842479083550265 21.362446628901004 -9.813993624534364 6.213707579124729 1.0000000155892705 0.6349750168814671 0.948170318738036 0.04023114742120424 8.664830098366089e-09 1.681472968849508e-09 0.03895364215084042 0.012984546996644471 1.5346395112219677e-10 9.813993624534364 -0.36502499870780347 VMMVALGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VMMVALGR 8 0 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 0 10784200.0 2656900.0 5578100.0 2549200.0 False True 4030711.545408141 4582644.473105775 2045349.5026459503 1.0 1.136931884477421 0.5074412990371512 21.942603110910678 -6.849731553451555 1.2363740411753372 1.073055291883532 0.48240499241099344 0.9399167530272714 0.06625884724878911 0.1577512347508052 0.46417160636331445 0.0419379982697217 0.0970312143442863 1.4134109336738925e-07 6.849731553451555 -0.5906502994725387 VMMVALGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMMVALGR 8 0 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 0 15973500.0 5982900.0 3984700.0 6005900.0 False True 8194939.811793126 3808642.778359201 4587430.115393182 1.0 0.46475543028129157 0.5597881400900017 22.9663019227311 -10.247715436504313 7.142774156723658 1.0000020643297653 0.5122717851857705 0.9723141200198563 0.038796941317554276 1.2753777816801097e-06 1.3436231904125036e-07 0.03756513611049541 0.012521658967222841 5.653072607041727e-11 10.247715436504313 -0.4877302791439948 VMMVALGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VMMVALGR 8 0 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 0 7063500.0 2784500.0 2304900.0 1974100.0 False True 2315435.124265518 2292483.046213168 2386875.182792885 1.0 0.9900873586084039 1.0308538372674245 21.14285190433528 -6.84246142442273 1.2710445161162416 0.9947274438956035 1.0322602331976842 0.92858246162462 0.004639121678417073 0.16594547600521742 0.5197275286976469 0.0028608359769308456 0.006595319956792273 1.437270711172489e-07 6.84246142442273 0.037532789302080705 VMMVALGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VMMVALGR 8 0 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 0 13140700.0 2656900.0 5297600.0 5186200.0 False True 3439409.4253287897 5002783.903035339 4242364.81490574 1.0 1.4545473610072168 1.233457344061384 21.713729433003127 -10.115548444652347 4.480641819784671 0.9999632312808773 1.3440023525080727 0.7634772968821102 0.09025962150427745 19735112194.289734 8723028899.883593 8294190.975664574 0.03303164025447942 7.66393045833174e-11 10.115548444652347 0.3440391212271954 VMNK(ub)DQWYNVLEFSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VMNKDQWYNVLEFSR 15 1 Q9BTE7;E9PM04 Q9BTE7 DCUN1D5 DCN1-like protein 5;DCN1-like protein 1 4852040.0 991340.0 1085000.0 2775700.0 True False 824343.1338083585 1079154.8896443625 3356086.0366132474 1.0 1.3091088472573391 4.071224589581482 19.65288546038829 -6.92809854800668 0.7622406384090534 0.9549006529879005 4.611754344174941 0.9961511365727365 0.0856581837230422 0.09363718244655493 0.08260628859430408 0.07717370595415499 0.2525872815110374 1.1800528333780551e-07 6.92809854800668 3.656853691187041 up VMNLISK(ub)LSAK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VMNLISKLSAK 11 1 P50502;Q8NFI4 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 172120400.0 52831000.0 61834000.0 57455400.0 True False 51153908.82322732 86524638.66005023 42406107.11494667 1.0 1.691457029394442 0.8289905520512528 25.608341149038928 -6.693251256251319 1.8547882539396967 1.4321795905596366 0.83184862016058 0.3856436902623448 0.2922491290524953 0.4097609343226027 2.735551535065685 0.12593003332041203 0.32660205557292327 2.0265099654682273e-07 6.693251256251319 -0.6003309703990566 VMNLISK(ub)LSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMNLISKLSAK 11 1 P50502;Q8NFI4 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 15951100.0 6507400.0 5020500.0 4423200.0 True False 8913361.63587267 4798677.709426644 3378531.2586634965 1.0 0.538369013337674 0.3790411964287724 23.087538209909116 -13.999999999999998 0.14840929034491787 3.2268917159076596 0.20050213370350545 0.9995716359547638 0.005450101218228488 11.952088087595161 0.12124224885679345 7.6792218418015485 0.16068353386012083 1.0000000000000041e-14 13.999999999999998 -3.026389582204154 VMNLISK(ub)LSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VMNLISKLSAK 11 1 P50502;Q8NFI4 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 144031600.0 52831000.0 60855900.0 30344700.0 True False 43931317.3101352 60528057.18774969 36689636.471959576 1.0 1.3777883499474652 0.8351590327453047 25.388746424473204 -6.719490287485725 1.7609319630914788 1.2299740112047837 0.8360204389708589 0.5100825224823864 0.15898631261282983 0.3563737007365068 2.1593546130208114 0.07169149904613037 0.1800952277920171 1.9076983870710062e-07 6.719490287485725 -0.3939535722339248 VMNLIVFHSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VMNLIVFHSR 10 0 P55160;P55160-2 P55160 NCKAP1L Nck-associated protein 1-like 0 17425000.0 5534500.0 6624700.0 5265800.0 False True 7255783.096174245 5636320.582878342 4720945.529120334 1.0 0.7768038967220786 0.6506459008689973 22.790699898019852 -13.999999999999993 0.06619572913763397 2.3350170711580827 0.154619774339855 0.9999367314108273 0.0011489277786139284 12.399775762971368 0.06813651483045732 2.6203185966637803 0.4597624356162586 1.0000000000000164e-14 13.999999999999993 -2.1803972968182275 VMNLIVFHSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMNLIVFHSR 10 0 P55160;P55160-2 P55160 NCKAP1L Nck-associated protein 1-like 0 11293400.0 4949800.0 1869200.0 4474400.0 False True 4792671.308383537 2615581.3077492253 3302420.4108772585 1.0 0.5457460233448397 0.6890563108512218 22.19239856957198 -10.886212591818294 11.058459565296602 1.0211071787405284 0.6174011670980379 0.9047912006016271 0.058506179880365196 0.024928792394885893 0.00025650744608451 0.04638311615918204 0.01888278836057248 1.2995332867942206e-11 10.886212591818294 -0.4037060116424904 VMNLIVFHSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMNLIVFHSR 10 0 P55160;P55160-2 P55160 NCKAP1L Nck-associated protein 1-like 0 17154500.0 5534500.0 4225600.0 7394400.0 False True 7580754.21423877 4038899.019809429 5647995.012448304 1.0 0.5327832700634523 0.7450439432319009 22.853909959542744 -10.04061380612479 4.7762217018926965 1.0000086015996301 0.638913606638781 0.7941764374424485 0.08665505698153933 119929481.47521219 13.899345003594307 12462.193128098073 0.029664330889973962 9.107227676531527e-11 10.04061380612479 -0.36109499496084907 VMNLIVFHSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VMNLIVFHSR 10 0 P55160;P55160-2 P55160 NCKAP1L Nck-associated protein 1-like 0 12069600.0 4949800.0 4055400.0 3064400.0 False True 4115978.0133199687 4033552.755266127 3705151.8718152666 1.0 0.979974320128266 0.9001874790936194 21.972803845006258 -6.944968658308062 0.6116277242667827 1.0008805661631766 0.87511480841348 0.9987445772532539 0.001527609033757554 0.08557199345230064 0.044830252383386664 0.0015503970215465434 0.006731649489719684 1.1350927288543776e-07 6.944968658308062 -0.12576575774969656 VMNLIVFHSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VMNLIVFHSR 10 0 P55160;P55160-2 P55160 NCKAP1L Nck-associated protein 1-like 0 21280600.0 5648500.0 10865000.0 4767100.0 False True 7312094.598580924 10260353.198897416 3899536.7145766024 1.0 1.4032030166689402 0.5332995439273167 22.801853304383826 -6.780655944617834 1.5331844288343786 1.2281064893634503 0.526249356567047 0.7697562166851633 0.17055902805309023 0.24955137456809523 1.1586867821355493 0.08761292801524775 0.20662794358973494 1.6570822119658377e-07 6.780655944617834 -0.7018571327964034 VMPAQLK(ub)VLTMPETCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VMPAQLKVLTMPETCR 16 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 34713700.0 8278700.0 13507000.0 12928000.0 True False 10853455.871044852 11491808.249873634 11590334.57413265 1.0 1.0588155870732194 1.0678934628604022 23.371651151505237 -13.999999999999773 0.2630511837523445 0.5625051874273929 1.0711156671625972 0.9995685844151159 0.0006250561144928083 14.55560706047507 0.16232903050504377 3.391271764942869 0.003906293774181112 1.0000000000005235e-14 13.999999999999773 0.5086104797352043 VMPAQLK(ub)VLTMPETCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMPAQLKVLTMPETCR 16 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 53940000.0 12843000.0 23183000.0 17914000.0 True False 12435305.994902784 32440092.797747895 13221785.991519598 1.0 2.608708849709452 1.0632457292920006 23.567938672522068 -6.636806615821437 2.0561076689788726 2.054541105804484 1.069638263314791 0.1424619197057554 0.6888704953333527 0.5414467541256754 4.370802005491175 0.27321911557731493 0.7627768164448963 2.3077745739655374e-07 6.636806615821437 -0.9849028424896928 VMPAQLK(ub)VLTMPETCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VMPAQLKVLTMPETCR 16 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 83452000.0 17282000.0 24554000.0 41616000.0 True False 26218057.483436886 20172146.85872235 33390579.359059248 1.0 0.7693989866131766 1.2735718265990363 24.644057463317043 -6.782328520302968 1.5265804330607458 0.869821658808023 1.2778760530303372 0.7755974261317755 0.09762092148635701 0.2469824472491325 1.1369756118089547 0.05035643843692267 0.11860176578851774 1.6507126509290638e-07 6.782328520302968 0.40805439422231427 VMPAQLK(ub)VLTMPETCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMPAQLKVLTMPETCR 16 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 36631700.0 8278700.0 13107000.0 15246000.0 True False 11339559.11345533 12527889.400947135 11645208.801226202 1.0 1.1047951049597469 1.0269542832056138 23.434861213028128 -10.42438805056155 4.454635380492244 0.9998202879261185 1.0658746940828063 0.4884667400581839 0.03177838240985471 5.687282289821457e-05 7.348845058391378e-06 0.030853133518730046 0.010256428820171568 3.7636735714805937e-11 10.42438805056155 0.06605440615668778 VMPAQLK(ub)VLTMPETCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VMPAQLKVLTMPETCR 16 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 45293000.0 12843000.0 16035000.0 16415000.0 True False 10679523.541369021 15948616.272301685 19847300.605615366 1.0 1.4933827535022421 1.858444389277606 23.348343947956344 -6.974427753100048 0.10910456231241539 0.22184211860103656 3.1392966569387943 0.9999996316043118 0.00021342550752086233 0.0748904052982494 0.0032227001422784674 0.029312026034319334 0.05621278946795866 1.0606503678016336e-07 6.974427753100048 2.9174545383377577 VMPAQLK(ub)VLTMPETCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VMPAQLKVLTMPETCR 16 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 52040000.0 17282000.0 24628000.0 10130000.0 True False 22371889.679149427 23257430.150248084 8286443.942577456 1.0 1.0395827301045553 0.3703953515513896 24.415183785409493 -6.892856497500172 1.00536696139721 1.0335329665972341 0.30951960026952174 0.9826633343428548 0.04036364478132125 0.11685474244504347 0.20857119763690632 0.030471301981751853 0.07678710807447088 1.2798041157718156e-07 6.892856497500172 -0.7240133663277124 down VMPLIIQGFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VMPLIIQGFK 10 0 P49903-4;P49903;Q5T5U6;P49903-2;P49903-3;Q5T5U7 P49903-4 SEPHS1 Selenide, water dikinase 1 0 4496500.0 1007900.0 1464300.0 2024300.0 False True 1321366.6605174837 1245832.1477966933 1814844.8544567395 1.0 0.9428360689142792 1.3734604547582547 20.33359941888495 -6.873452672197977 1.1156152626282596 0.9668829872533556 1.4003977695386802 0.9680118679587248 0.03415291450741916 0.1335901808963984 0.30865130691476006 0.023704361987779428 0.05648512379137507 1.3382810481132128e-07 6.873452672197977 0.4335147822853246 VMPNAIVQSVGVSSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VMPNAIVQSVGVSSGK 16 0 O95831-3;O95831;E9PMA0;O95831-2;O95831-5 O95831-3 AIFM1 Apoptosis-inducing factor 1, mitochondrial 0 6639700.0 2150400.0 1832600.0 2656700.0 False True 2819195.224503219 1559183.2234188512 2381810.1688658884 1.0 0.553059685213393 0.8448546408436812 21.426851954884356 -10.186820983475075 7.117575417875713 1.0000004906426754 0.6989571630285375 0.5866380728692047 0.11912479180204397 9.273781823148301e-07 1.0600876123001943e-07 0.11534227102678814 0.03844736123081184 6.503977295488415e-11 10.186820983475075 -0.3010433276141379 VMQLALFQGIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMQLALFQGIAK 12 0 Q96BP3;F5H7P7;Q96BP3-2 Q96BP3 PPWD1 Peptidylprolyl isomerase domain and WD repeat-containing protein 1 0 7679600.0 1460000.0 2412900.0 3806700.0 False True 1999801.4550164593 2306290.0996067245 2907635.861447446 1.0 1.1532595367512335 1.4539622691811247 20.93142534228323 -6.960417946057918 0.42950497950817246 0.9879927247799789 1.630751081151297 0.9997853815692772 0.0027623652982513795 0.07955219113940111 0.020582340837984648 0.003919244043668573 0.024970508152954665 1.095423500952346e-07 6.960417946057918 0.6427583563713182 VMQVLNADAIVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMQVLNADAIVVK 13 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 14024200.0 3789800.0 2279300.0 7955100.0 False True 3669494.8734316393 3189436.3763924786 5871420.662115522 1.0 0.8691758638184935 1.6000623695175475 21.807150050989197 -6.860608225271455 1.1825483058169897 0.9288949917559125 1.6358873438182506 0.9543826541936558 0.06796646168599724 0.14618245782508318 0.3880831893250357 0.04481377339332405 0.10468906931656641 1.378452402725125e-07 6.860608225271455 0.7069923520623381 VMQVLNADAIVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMQVLNADAIVVK 13 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 20322900.0 4008000.0 10416000.0 5898900.0 False True 5489865.912127382 9955786.678894121 4505701.311659007 1.0 1.8134844891022388 0.8207306669741592 22.38833948171106 -6.688927687787932 1.8698867493870026 1.5105301483004303 0.824183246990681 0.36538826945407876 0.3441255629191951 0.419077120118082 2.840016575471841 0.1472593211948429 0.38404066478712795 2.0467854084023217e-07 6.688927687787932 -0.6863469013097493 VMQVLNADAIVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VMQVLNADAIVVK 13 0 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 8281800.0 3789800.0 2029500.0 2462500.0 False True 3151386.616606734 2018566.6806757895 2977397.364686435 1.0 0.6405328594208755 0.9447896202251305 21.587555326423473 -10.073277543084995 7.020829381799917 1.00000006461305 0.7926612398230029 0.38240470891194167 0.12421230246040983 1.256043094843693e-07 1.6464249443214428e-08 0.12026808323655937 0.04008934823527047 8.447388282796206e-11 10.073277543084995 -0.20733882479004717 VMSQNFTNCHTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VMSQNFTNCHTK 12 0 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 5671820.0 319720.0 3079400.0 2272700.0 False True 419156.0161728841 2619965.523407183 2037542.8052777941 1.0 6.250573586725183 4.861060623396598 18.677127811115472 -9.945174465375581 7.0009612611287615 0.9999998153414877 5.555817105060902 0.9347824531198744 0.5672662918563164 1.6656771610290738e-06 2.478397236143937e-07 0.5492532253009047 0.18308440843535576 1.1345549491408035e-10 9.945174465375581 4.555817289719415 VMSQNFTNCHTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMSQNFTNCHTK 12 0 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 3524690.0 1573600.0 355390.0 1595700.0 False True 1523646.9293450902 497299.08033436624 1177738.300026114 1.0 0.3263873478536924 0.7729732376596866 20.539097198995158 -9.823729173050014 5.54278854096385 1.0000001360506077 0.5496802927530342 0.5755016960381356 0.18231792607289887 246875239.70505932 40.19671091702865 428.3980377421303 0.0624122754650971 1.5006203337708864e-10 9.823729173050014 -0.45031984329757346 VMSQNFTNCHTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMSQNFTNCHTK 12 0 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 0 6431220.0 319720.0 3542600.0 2568900.0 False True 437929.1241081249 3386076.2181883985 1962178.7281562355 1.0 7.732018794329776 4.480585145261481 18.740337872638364 -10.517582130808448 6.850079344543124 0.9974677886180708 6.106301969795526 0.7668199172963501 1.3273922287888116 0.051276951905935356 0.0036111820560916458 1.28382118682513 0.42841399966535093 3.0368117365287275e-11 10.517582130808448 5.108834181177455 VMSQNFTNCHTK(ub)IR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMSQNFTNCHTKIR 14 1 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 3470900.0 1879300.0 1591600.0 0.0 True False 1819642.650176813 2227134.180084351 0.0 1.0 1.223940414821527 0.0 20.795223724452985 -6.907058316662369 1.2843580227082563 1.1169175331522765 3.9433156734445914e-23 0.951599594454483 0.11706262256729183 0.12997467569349946 0.42993424045083245 0.07462353293720338 0.14763801967228463 1.2386302532353785e-07 6.907058316662369 -1.1169175331522765 down VMSQNFTNCHTK(ub)IR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMSQNFTNCHTKIR 14 1 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 3267760.0 1144000.0 793160.0 1330600.0 True False 1566967.7154375543 758115.5685706278 1016339.6845672025 1.0 0.48381058595003307 0.6486028235006766 20.57954402529424 -10.402501648453978 5.1487921893680655 1.000363821189686 0.5662067047253335 0.9023354167614691 0.06727614926184061 0.0002811979665275436 3.263193724428095e-05 0.06519325802164015 0.021713283807328555 3.9582056241456346e-11 10.402501648453978 -0.4341571164643524 VMSQNFTNCHTK(ub)IR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VMSQNFTNCHTKIR 14 1 Q13283;E5RIZ6;E5RIF8;E5RH42;E5RJU8;Q13283-2;E5RI46 Q13283 G3BP1 Ras GTPase-activating protein-binding protein 1 1 5107800.0 1879300.0 1895400.0 1333100.0 True False 1562721.2171061907 1885189.1039925572 1611845.0464420244 1.0 1.2063502327584088 1.0314348002689822 20.57562899988726 -10.342029418628366 8.794452223686491 0.9999998054688133 1.1188925165136956 0.38119398707950125 0.07140892628955567 2.7216645462517965e-07 2.0325926836007274e-08 0.06914150838805298 0.023047131857500194 4.549572408054019e-11 10.342029418628366 0.1188927110448823 VMTIPYQPMPASSPVICAGGQDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VMTIPYQPMPASSPVICAGGQDR 23 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 15984000.0 2407900.0 9593500.0 3982600.0 False True 3156780.218136773 8162187.195170114 3570518.755796773 1.0 2.5856051518175325 1.1310634599402682 21.590022389923842 -6.625639896188879 2.096017292509342 2.047899604121875 1.1367733345582847 0.10211593943550845 0.6808882089242355 0.5704383299281538 4.769720763783792 0.2662030121510432 0.7546283149620849 2.367882259870616e-07 6.625639896188879 -0.9111262695635902 VMTIPYQPMPASSPVICAGGQDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMTIPYQPMPASSPVICAGGQDR 23 0 Q15365 Q15365 PCBP1 Poly(rC)-binding protein 1 0 21625900.0 2407900.0 9374700.0 9843300.0 False True 3298165.70105078 8960494.756012745 7518515.2691269675 1.0 2.7168115759490115 2.2796050746424306 21.653232451446733 -10.171864669545714 5.094795614397264 0.9999095612291986 2.498208325297204 0.9399653583339327 0.17848880674336243 0.00018338246253335228 2.9807725811414925e-05 0.17283127721811473 0.05760701466603435 6.731863951405653e-11 10.171864669545714 1.4982987640680052 VMTVSFHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VMTVSFHK 8 0 Q92769-3;Q92769;Q13547;Q5TEE2;O15379-2;O15379;E7ESJ6 Q92769-3;Q13547;O15379-2 HDAC2;HDAC1;HDAC3 Histone deacetylase 2;Histone deacetylase 1;Histone deacetylase 3 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 VMTVSFHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMTVSFHK 8 0 Q92769-3;Q92769;Q13547;Q5TEE2;O15379-2;O15379;E7ESJ6 Q92769-3;Q13547;O15379-2 HDAC2;HDAC1;HDAC3 Histone deacetylase 2;Histone deacetylase 1;Histone deacetylase 3 0 42291000.0 13722000.0 4866000.0 23703000.0 False True 13286402.62104304 6809019.175854774 17494473.225242216 1.0 0.5124802679899698 1.3167200877635925 23.66344720273682 -6.742600179233412 1.6769707866508803 0.7107987275252756 1.3174800055861384 0.6165736383233269 0.20482892126847463 0.3131681286023826 1.7301866856602959 0.09658361823847825 0.23635328481809123 1.8088386151355768e-07 6.742600179233412 0.6066812780608628 VMTVSFHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMTVSFHK 8 0 Q92769-3;Q92769;Q13547;Q5TEE2;O15379-2;O15379;E7ESJ6 Q92769-3;Q13547;O15379-2 HDAC2;HDAC1;HDAC3 Histone deacetylase 2;Histone deacetylase 1;Histone deacetylase 3 0 13180000.0 0.0 13180000.0 0.0 False True 0.0 12597664.019568421 0.0 0.0 VMTVSFHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VMTVSFHK 8 0 Q92769-3;Q92769;Q13547;Q5TEE2;O15379-2;O15379;E7ESJ6 Q92769-3;Q13547;O15379-2 HDAC2;HDAC1;HDAC3 Histone deacetylase 2;Histone deacetylase 1;Histone deacetylase 3 0 42940000.0 13722000.0 18512000.0 10706000.0 False True 11410450.987671532 18412272.18165569 12944575.101048913 1.0 1.6136322921459725 1.134449034050883 23.443852478171095 -10.13994928675928 4.472768197623019 0.9999467755492392 1.374040663110497 0.44824723445850223 0.19562574597718885 136711038.41495916 8.249137185574487 74938.89722080872 0.0669678961817072 7.245205585256932e-11 10.13994928675928 0.37409388756125794 VMTVSFHK(ub)YGEYFPGTGDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMTVSFHKYGEYFPGTGDLR 20 1 Q92769-3;Q92769;Q13547;Q5TEE2 Q92769-3;Q13547 HDAC2;HDAC1 Histone deacetylase 2;Histone deacetylase 1 1 9453900.0 2163400.0 3058800.0 4231700.0 True False 2094724.051185287 4280194.79143128 3123290.821721194 1.0 2.0433215482532687 1.4910273360130173 20.998328772099438 -10.244113256972774 4.936166239736211 0.9998575339168944 1.7671744421339006 0.7200981863473579 0.22547316798279024 0.00035357149161511993 5.414317255592681e-05 0.21835341207241038 0.07277115205079011 5.700156020516357e-11 10.244113256972774 0.7673169082170063 VMTVSFHK(ub)YGEYFPGTGDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VMTVSFHKYGEYFPGTGDLR 20 1 Q92769-3;Q92769;Q13547;Q5TEE2 Q92769-3;Q13547 HDAC2;HDAC1 Histone deacetylase 2;Histone deacetylase 1 1 44739100.0 8447100.0 10861000.0 25431000.0 True False 12814868.265729621 8922769.692619685 20404551.70319673 1.0 0.6962825920326902 1.592256063822673 23.61131531230217 -6.815234142638097 1.392247802663645 0.8354659232447055 1.6099061414037998 0.8730958430969544 0.1325370626019792 0.19974700936046863 0.7620130878232775 0.07482919493652976 0.1727362877238721 1.530262223849161e-07 6.815234142638097 0.7744402181590944 VMVLDFVTPTPLGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VMVLDFVTPTPLGTR 15 0 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;E9PKD3;A0A0B4J225;E9PIZ5;E9PKI4;E9PLT3;E9PQI3 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 5313180.0 1394600.0 3102800.0 815780.0 False True 1828334.10532561 2639874.334619668 731370.9111143205 1.0 1.443868670901115 0.40002038412124347 20.802098298392394 -6.791149892263655 1.4915636404526142 1.2477070949730913 0.38853570583318675 0.8050889850695273 0.18883950893923027 0.2336350065021523 1.0267920945147224 0.09964301168266503 0.23311212093216335 1.617521670360389e-07 6.791149892263655 -0.8591713891399045 down VMVLDFVTPTPLGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMVLDFVTPTPLGTR 15 0 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;E9PKD3;A0A0B4J225;E9PIZ5;E9PKI4;E9PLT3;E9PQI3 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 9909900.0 1394600.0 3561100.0 4954200.0 False True 1910221.307647913 3403758.827017074 3784119.9949517767 1.0 1.7818662232430955 1.9809851244991221 20.865308359915286 -10.901893651013294 0.2663657959364955 1.2898228545214297e-13 2.0644471085125637 0.9992016471242011 0.011962805119739933 2.762725017293572 0.1381574201153705 1.8049815137993177 0.0835800617861909 1.2534480787094688e-11 10.901893651013294 2.064447108512435 VMVQPINLIFR ddPTM_RPMI8226_Bortezomib_1h_R1 2 VMVQPINLIFR 11 0 P62304 P62304 SNRPE Small nuclear ribonucleoprotein E 0 266178990.0 77125730.0 114638870.0 74414390.0 False True 101112578.91663182 97535197.45481534 66714702.75603284 1.0 0.964619817829332 0.6598061632968504 26.591387246070536 -6.928743931371879 0.7570320069020412 1.0048578053712713 0.5991852917063086 0.9962855418610613 0.009307379226667457 0.09329539163675318 0.08091418641441482 0.00841695002796436 0.02777334024544348 1.1783005180648232e-07 6.928743931371879 -0.4056725136649627 VMVQPINLIFR ddPTM_RPMI8226_Bortezomib_2h_R1 2 VMVQPINLIFR 11 0 P62304 P62304 SNRPE Small nuclear ribonucleoprotein E 0 257849710.0 101154000.0 77490110.0 79205600.0 False True 97942921.63890009 108432315.02858515 58459277.24293321 1.0 1.1070970031745406 0.5968708740225581 26.54543789651597 -6.851897195020648 1.2259207760458133 1.0572557230858401 0.5757171873110298 0.9430210966175769 0.05243695714391712 0.15537946078615936 0.4484148107220984 0.03345359580373974 0.07751236037099754 1.4063803991781624e-07 6.851897195020648 -0.4815385357748103 VMVQPINLIFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VMVQPINLIFR 11 0 P62304 P62304 SNRPE Small nuclear ribonucleoprotein E 0 81404000.0 15618000.0 35454000.0 30332000.0 False True 23693647.828741845 29126956.696633626 24336866.90501212 1.0 1.229315000677137 1.0271473215487743 24.49799699446115 -10.396324527118333 3.5284649226063527 0.9990540279779418 1.1282311610187759 0.34913497719635755 0.08253460961657466 9987577.017581837 10126466.1456396 63746.043199812455 0.028253790930281047 4.014906842901648e-11 10.396324527118333 0.129177133040834 VMVQPINLIFR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VMVQPINLIFR 11 0 P62304 P62304 SNRPE Small nuclear ribonucleoprotein E 0 460337680.0 77125730.0 119733150.0 263478800.0 False True 105641196.62548405 114442943.52842103 201250533.95621878 1.0 1.083317372238225 1.90503837882191 26.654597307593427 -6.926422182526726 0.7755926465033837 0.9857083481971389 2.059329926826119 0.9957872493336188 0.026508784242277966 0.09453847212823352 0.08709506561976134 0.023655331979351504 0.07586668902236313 1.1846166091896059e-07 6.926422182526726 1.07362157862898 VMVQPINLIFR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VMVQPINLIFR 11 0 P62304 P62304 SNRPE Small nuclear ribonucleoprotein E 0 196051850.0 101154000.0 46497650.0 48400200.0 False True 84114032.88200887 46247157.93038914 58520458.0427599 1.0 0.5498150111915623 0.6957276454078667 26.325843171950247 -10.351540193529335 4.9704804421213655 1.000225656531689 0.6227713282996233 0.8991095027443838 0.05956858347620111 0.0001490466121967129 1.94449121335903e-05 0.05771114536758222 0.019225677646662612 4.451022672345405e-11 10.351540193529335 -0.3774543282320656 VMVQPINLIFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VMVQPINLIFR 11 0 P62304 P62304 SNRPE Small nuclear ribonucleoprotein E 0 80985000.0 15618000.0 34063000.0 31304000.0 False True 20217808.876805644 32167364.10621653 25606993.206164327 1.0 1.5910410619777746 1.266556300051945 24.2691233165536 -10.079606954581013 4.531725833580364 0.9999742803866826 1.4287986810309974 0.6995550575618428 0.13247034941664118 69564079.69683668 1.8104649634454533 20996.48606890945 0.04847918385948772 8.325168751213905e-11 10.079606954581013 0.4288244006443148 VMVSISLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMVSISLK 8 0 O15144;C9JTV5;G5E9J0 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 24810100.0 14715000.0 5813400.0 4281700.0 False True 14247880.379583782 8134720.936480504 3160194.321753349 1.0 0.5709425345918114 0.2218010144359218 23.76424397343175 -7.876540972041602 0.3052794955874809 1.1101919968284804 1.677442634028974e-14 0.9992666738788177 0.008618377593077453 0.11155555983693068 0.052588788849609665 0.047227230686250746 0.08555917277260774 1.3287981902495055e-08 7.876540972041602 -1.1101919968284635 down VMVSISLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VMVSISLK 8 0 O15144;C9JTV5;G5E9J0 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 425514500.0 118777500.0 147344000.0 159393000.0 False True 180194151.29839852 121049311.99607362 127888903.68556619 1.0 0.6717715926063437 0.7097283833246302 27.424976944336187 -10.153655644827465 7.875162636266915 1.000000066866843 0.6907499881518677 0.9888277285215373 0.015495794922235089 1.8176674880783077e-08 1.98727651171889e-09 0.015003742047517553 0.005001246305838489 7.020117078586267e-11 10.153655644827465 -0.30925007871497523 VMVSISLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMVSISLK 8 0 O15144;C9JTV5;G5E9J0 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 13341900.0 1773400.0 4729000.0 6839500.0 False True 2429073.90433301 4520057.143288247 5224150.963924077 1.0 1.8608149942351764 2.150676006442281 21.21197495381946 -10.484892416542621 0.23442194809611386 1.4408767203601226e-15 2.3249055668448886 0.9992154739343289 0.013687004086680554 2.1459091895076967 0.11691331697891409 1.4062151689563653 0.1434102343773752 3.2742179378161856e-11 10.484892416542621 2.3249055668448873 VMVSISLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VMVSISLK 8 0 O15144;C9JTV5;G5E9J0 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 24305300.0 14715000.0 4618300.0 4972000.0 False True 12236174.485030381 4593420.301239226 6011622.212069422 1.0 0.3753967636583454 0.49129915721813083 23.544649248866026 -10.008553805797881 6.011862183473969 1.0000006206954735 0.43334796043942625 0.9695774459334693 0.04731695403164683 3.9357541119763315e-07 6.495468632535756e-08 0.04581449357217904 0.015271481246457346 9.804968306635619e-11 10.008553805797881 -0.5666526602560472 VMVSISLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VMVSISLK 8 0 O15144;C9JTV5;G5E9J0 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 0 405232800.0 118777500.0 177038000.0 109417300.0 False True 153759815.20455793 167185679.67109075 89504474.11630602 1.0 1.0873171215032447 0.5821057601898888 27.196103266428636 -6.862336281500593 1.1737703595769204 1.0477067141002177 0.556514260736266 0.956423624124068 0.04602486552287025 0.14442038453575112 0.376752852020485 0.03055082055073925 0.07151795181608253 1.3729784430765923e-07 6.862336281500593 -0.4911924533639517 VMVTNVTSLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VMVTNVTSLLK 11 0 Q9Y490;Q9Y4G6;H0YMT1;A0A1B0GVU7 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 16316400.0 4771600.0 3391100.0 8153700.0 False True 6255613.808240136 2885161.0984042687 7310033.339813234 1.0 0.46121151126749915 1.168555726727276 22.57672001960778 -6.703064832951285 1.819711264487414 0.6664514825855186 1.16659418670793 0.4322605391914459 0.22730334002425606 0.38916983035444724 2.5073881909870455 0.09956783065784591 0.2551195973367937 1.9812312388175198e-07 6.703064832951285 0.5001427041224114 VMVTNVTSLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMVTNVTSLLK 11 0 Q9Y490;Q9Y4G6;H0YMT1;A0A1B0GVU7 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 13260700.0 3683100.0 1947100.0 7630500.0 False True 3566182.006527014 2724587.183992364 5631843.139906792 1.0 0.7640067666220292 1.5792360371958292 21.765948904708058 -6.829259451973481 1.3311394096401523 0.873832039655659 1.6008547364001056 0.9043970609252389 0.10590255073573764 0.18172886990363338 0.6300193735208399 0.06246904674494439 0.14376922897545216 1.481632678153225e-07 6.829259451973481 0.7270226967444465 VMVTNVTSLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMVTNVTSLLK 11 0 Q9Y490;Q9Y4G6;H0YMT1;A0A1B0GVU7 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 12760100.0 4771600.0 3799900.0 4188600.0 False True 6535789.467641471 3632007.8534110826 3199338.946924832 1.0 0.5557106561331362 0.489510710644013 22.63993008113067 -13.999999999999998 0.26807721083977654 4.394059596526752 0.46712380309924784 0.9995792105163324 0.004649517778863681 14.789516327160955 0.16388542966071643 27.325169510404645 0.02776076289204535 1.0000000000000041e-14 13.999999999999998 -3.926935793427504 VMVTNVTSLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VMVTNVTSLLK 11 0 Q9Y490;Q9Y4G6;H0YMT1;A0A1B0GVU7 Q9Y490;Q9Y4G6 TLN1;TLN2 Talin-1;Talin-2 0 6424300.0 3683100.0 1734700.0 1006500.0 False True 3062660.838995269 1725354.8267890094 1216954.4964698057 1.0 0.5633515813507532 0.3973520283326696 21.546354180142334 -13.999999999999998 0.13407308539331197 3.077526309003509 0.17647356065431394 0.9996275828797407 0.00490491657579754 11.93253495788898 0.11424996156972811 6.510880556900613 0.19678059747983784 1.0000000000000041e-14 13.999999999999998 -2.9010527483491955 VMYEK(ub)EAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VMYEKEAK 8 1 E5RJD8;O75347;E5RHG6;O75347-2;E5RIX8;A0A494C144 E5RJD8 TBCA Tubulin-specific chaperone A 1 6984760.0 3539800.0 2944400.0 500560.0 True False 3427430.9865885563 4120114.274843156 369448.31952188467 1.0 1.2020998499940774 0.10779161446795744 21.708696186077372 -6.859005569639986 1.1906792773942416 1.1093763477279175 0.0557743925902738 0.9524361228846397 0.10368944412167873 0.14782008134960878 0.39877288637856306 0.06794800122696208 0.1584450130300154 1.383548635441675e-07 6.859005569639986 -1.0536019551376437 down VMYEK(ub)EAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMYEKEAK 8 1 E5RJD8;O75347;E5RHG6;O75347-2;E5RIX8;A0A494C144 E5RJD8 TBCA Tubulin-specific chaperone A 1 5008940.0 2214900.0 2251500.0 542540.0 True False 3033808.3854218903 2152021.2852851516 414403.22596203967 1.0 0.7093464754155477 0.13659505588861096 21.53269853752896 -7.288071577029176 0.550440653168016 1.0054692933018021 7.861695944666912e-27 0.9978755484179785 0.016533122047364256 0.09824478814568893 0.05609528708136622 0.01676054967851111 0.05730794983384732 5.1514373561235266e-08 7.288071577029176 -1.0054692933018021 down VMYTPMAPGNYLISVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VMYTPMAPGNYLISVK 16 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7 O75369-2 FLNB Filamin-B 0 2408550.0 0.0 1425000.0 983550.0 False True 0.0 1212395.5546064933 881781.6808777985 0.0 VMYTPMAPGNYLISVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VMYTPMAPGNYLISVK 16 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7 O75369-2 FLNB Filamin-B 0 3857600.0 0.0 1338800.0 2518800.0 False True 0.0 1279647.3891804407 1923911.3163143476 0.0 VNADIEK(ub)VNQNQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNADIEKVNQNQAK 14 1 Q15738;C9JDR0 Q15738 NSDHL Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating 1 3483700.0 1144200.0 1308900.0 1030600.0 True False 951452.9966545539 1301848.6959036915 1246093.695043994 1.0 1.3682743135826776 1.3096744657123782 19.85977286118482 -10.091562075106745 4.512054041671965 0.9999732981328214 1.3389743896327333 0.978077318188395 0.023923287765650225 16638763.343593908 0.013203328705364593 4666.121409862482 0.008189577716703244 8.09912170056054e-11 10.091562075106745 0.33900109149991187 VNAIHFLVHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNAIHFLVHK 10 0 A1A4S6;H0Y8W5 A1A4S6 ARHGAP10 Rho GTPase-activating protein 10 0 16025000.0 4699800.0 5048600.0 6276600.0 False True 6161483.312927939 4295368.55928867 5627157.641398602 1.0 0.6971322230600199 0.9132797015925983 22.55484627586075 -10.10228652712543 6.6939784821922395 1.0000001906781746 0.8052059623263089 0.5199009169392794 0.08824183859900035 2.511075665973006e-07 3.3664340235780275e-08 0.08543987686052248 0.028479930944387503 7.901571473767213e-11 10.10228652712543 -0.19479422835186566 VNAIHFLVHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNAIHFLVHK 10 0 A1A4S6;H0Y8W5 A1A4S6 ARHGAP10 Rho GTPase-activating protein 10 0 12883100.0 4699800.0 2246900.0 5936400.0 False True 6437443.06731942 2147624.528495316 4534344.58399575 1.0 0.3336145276993644 0.7043704366124781 22.618056337383642 -10.709795954749387 6.936924020361067 1.004666899535032 0.51899248215626 0.6917599272073699 0.1513604659931544 0.010969693903248616 0.0004589132760249408 0.14715766449591347 0.04885138033880674 1.950760913512908e-11 10.709795954749387 -0.48567441737877204 VNALK(ub)NLQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNALKNLQVK 10 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 8906200.0 2239900.0 3805300.0 2861000.0 True False 2936530.5912224576 3237564.0729432264 2564971.164649873 1.0 1.1025133137112837 0.8734699281924024 21.48568123647164 -6.785053532595046 1.5162790274011966 1.0576654766569396 0.8713629869248156 0.7848237392402113 0.04345439327680753 0.24280596748314787 1.1028662829430325 0.022565734219412444 0.05302308721565785 1.6403875610622846e-07 6.785053532595046 -0.18630248973212393 VNALK(ub)NLQVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNALKNLQVK 10 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 14890300.0 4009400.0 4404100.0 6476800.0 True False 3882123.7916346006 6162680.097078097 4780331.780164908 1.0 1.5874506913864406 1.2313702593579865 21.888414692200545 -10.411050955324063 5.242480558905923 0.9996653390548307 1.4094104753722245 0.6380256919421412 0.1453692276432885 0.000569067533257853 6.3929897893583e-05 0.140865880485544 0.04691771647611871 3.8810482737970974e-11 10.411050955324063 0.40974513631739384 VNALK(ub)NLQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNALKNLQVK 10 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 6546700.0 2239900.0 1823300.0 2483500.0 True False 3068051.561021487 1742740.5771531933 1896948.4492880274 1.0 0.5680284514426347 0.6182909288057894 21.54889129799453 -10.415582834165056 5.082396568037918 1.0004356966076189 0.5931596901241868 0.9886823075405774 0.020519570458074402 0.00010140892403560013 1.166081824686924e-05 0.019888743313861538 0.00662266288794172 3.840759963351426e-11 10.415582834165056 -0.4072760064834321 VNALK(ub)NLQVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNALKNLQVK 10 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 1 13503000.0 4009400.0 7443000.0 2050600.0 True False 3333993.7465362386 7402903.081680167 2479370.979096852 1.0 2.2204310039187116 0.7436639560805194 21.66881996763482 -6.687233926760696 1.8763876638016397 1.7671096089437783 0.7489493542779352 0.35747223154984364 0.5164498826478691 0.42262652584592625 2.882788095891499 0.2203721089901901 0.5758428495682764 2.0547835169210547e-07 6.687233926760696 -1.018160254665843 VNAMTFTFDNVLPGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNAMTFTFDNVLPGK 15 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;H3BPS9;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 10196200.0 2476600.0 4332500.0 3387100.0 False True 3246846.583428515 3686107.8879527324 3036635.3833574187 1.0 1.1352885925581302 0.9352568115955995 21.63060778685366 -6.724534102971618 1.7427958812590723 1.0819086281235852 0.9354827293492105 0.5338220987305755 0.0569010515830221 0.34662829412190366 2.0598433718464206 0.02589889449280098 0.06467679194791419 1.8856708913809922e-07 6.724534102971618 -0.14642589877437473 VNAMTFTFDNVLPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNAMTFTFDNVLPGK 15 0 A0A0G2JN29;A0A087X117;Q15155;A0A0G2JP90;A0A087WW46;H3BPS9;Q5JPE7-2;Q5JPE7;J3KN36;P69849;Q5JPE7-3 A0A0G2JN29;Q5JPE7-2 NOMO1;NOMO2;NOMO3 Nodal modulator 1;Nodal modulator 2;Nodal modulator 3 0 12351800.0 2476600.0 4307200.0 5568000.0 False True 3392265.9475984676 4116893.6619943157 4252953.076559586 1.0 1.2136117054468691 1.2537204164580424 21.69381784837655 -13.323241939953826 0.2440395932458485 2.1447365607030206e-10 1.2712032699650497 0.9994925205775629 0.002508670705844306 9.943142604632332 0.1532792575383088 4.839031083081636 0.019152081946674542 4.750704964559847e-14 13.323241939953826 1.2712032697505762 VNCFCLVFPFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNCFCLVFPFR 11 0 Q9UN19;J3KNB3;Q9UN19-2 Q9UN19 DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 0 8067400.0 1119900.0 2526500.0 4421000.0 False True 1533957.2941595449 2414870.875981762 3376850.853353079 1.0 1.5742751673571653 2.2013982176754507 20.548826887652716 -6.969996588588561 0.2582675741185331 0.8201686278466095 2.9740686280836885 0.999982356086269 0.0020608535543694254 0.07630382063086284 0.009034105520963417 0.01323929879634775 0.05932510625037963 1.0715277221245897e-07 6.969996588588561 2.153900000237079 VNCFCLVFPFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNCFCLVFPFR 11 0 Q9UN19;J3KNB3;Q9UN19-2 Q9UN19 DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 0 21433400.0 9262600.0 5461800.0 6709000.0 False True 11990618.29314255 5157846.028691931 5488030.840153225 1.0 0.43015680280988594 0.45769373238174355 23.515402717079777 -10.664712425004378 6.626217245479568 1.0033376811740666 0.44392526759581635 0.9981641885803714 0.011241904422334663 0.000556191549041427 2.8143331940276266e-05 0.010921886194605141 0.0036283090506131397 2.1641510764219122e-11 10.664712425004378 -0.5594124135782503 VNCSFYFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNCSFYFK 8 0 P0DN76;Q01081;Q01081-2;Q8WU68-3;Q8WU68;A0A1B0GW87;M0QYK5;M0R2N4;Q01081-3;Q8WU68-2 P0DN76 U2AF1;U2AF1L4 Splicing factor U2AF 35 kDa subunit;Splicing factor U2AF 26 kDa subunit 0 28109900.0 9047600.0 8390300.0 10672000.0 False True 11861491.217083028 7138499.945133249 9567763.81305259 1.0 0.6018214585744764 0.8066240271099311 23.49978205995132 -10.084716959899962 4.816640293193156 1.0000115445112199 0.7042227428390164 0.7355181369210342 0.08361029849818681 116223852.78261891 9.521874948594899 14881.002158282929 0.028622029077841216 8.227786998053114e-11 10.084716959899962 -0.29578880167220345 VNCSFYFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNCSFYFK 8 0 P0DN76;Q01081;Q01081-2;Q8WU68-3;Q8WU68;A0A1B0GW87;M0QYK5;M0R2N4;Q01081-3;Q8WU68-2 P0DN76 U2AF1;U2AF1L4 Splicing factor U2AF 35 kDa subunit;Splicing factor U2AF 26 kDa subunit 0 7893120.0 4385800.0 987020.0 2520300.0 False True 4246575.179665545 1381142.233241303 1860157.8226206778 1.0 0.325236731909237 0.43803718147459747 22.01786836041005 -10.15223985185706 5.686408872422517 1.0000093439907545 0.38163695669649567 0.9756504943555876 0.04605059069875937 5.4552346416196856e-06 8.13369001637288e-07 0.04458896542392116 0.01486276423825454 7.043039890151323e-11 10.15223985185706 -0.6183723872942588 VNCSFYFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNCSFYFK 8 0 P0DN76;Q01081;Q01081-2;Q8WU68-3;Q8WU68;A0A1B0GW87;M0QYK5;M0R2N4;Q01081-3;Q8WU68-2 P0DN76 U2AF1;U2AF1L4 Splicing factor U2AF 35 kDa subunit;Splicing factor U2AF 26 kDa subunit 0 26641000.0 9047600.0 7635400.0 9958000.0 False True 12392742.222196514 7298042.781108698 7606125.491447622 1.0 0.588896521065148 0.6137564515643977 23.56299212147421 -10.61821788930225 6.483373491661874 1.0013346929537132 0.601326486314773 0.9970922184033245 0.01014902412736915 0.00019637551202137378 1.1563819213718086e-05 0.009855728349436054 0.0032755834521298343 2.408696661514806e-11 10.61821788930225 -0.4000082066389402 VNCSFYFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNCSFYFK 8 0 P0DN76;Q01081;Q01081-2;Q8WU68-3;Q8WU68;A0A1B0GW87;M0QYK5;M0R2N4;Q01081-3;Q8WU68-2 P0DN76 U2AF1;U2AF1L4 Splicing factor U2AF 35 kDa subunit;Splicing factor U2AF 26 kDa subunit 0 7494100.0 4385800.0 1193700.0 1914600.0 False True 3646987.023883533 1187269.301169102 2314934.0078898016 1.0 0.32554799164183085 0.6347524662768663 21.798273635844325 -10.512343654661588 6.313091806877996 1.0004337690673888 0.4801502289596278 0.7903035709591919 0.12623219817353015 0.0007712896471747614 5.957849626168208e-05 0.12232089764723696 0.04074126677343637 3.073663680266807e-11 10.512343654661588 -0.520283540107761 VNCYMPANGETVTLPTSPSIPVGISLGLLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNCYMPANGETVTLPTSPSIPVGISLGLLKR 31 1 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;J3QRY6 Q5TA45-4 CPSF3L Integrator complex subunit 11 1 46119700.0 5779200.0 9710500.0 30630000.0 True False 8767468.91611378 7977585.406517216 24575967.074394103 1.0 0.9099074639266945 2.803085737689448 23.06372897992938 -6.895729089313976 0.9878870427001869 0.9118022794407699 2.985426344041477 0.9843185907702694 0.10919580265010491 0.11461721620930533 0.19568496710644814 0.08352312683215744 0.2130082082117675 1.271366930118917e-07 6.895729089313976 2.073624064600707 up VNDFLAEIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNDFLAEIFK 10 0 Q14008-2;Q14008;Q14008-3;H0YDX5 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 5180100.0 1322300.0 1906000.0 1951800.0 False True 1733548.1051714148 1621632.2295298108 1749846.4589876335 1.0 0.9354411479509894 1.0094017314936912 20.72529644055157 -11.17371972690721 10.398435732089675 2.76597685037298 0.972421439722285 0.1563942478208793 0.030194281793017707 0.047286457975517907 0.0007899848511401931 0.0011183271248304716 0.009745162544587616 6.7031706074813954e-12 11.17371972690721 -1.7935554106506948 VNDFLAEIFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNDFLAEIFK 10 0 Q14008-2;Q14008;Q14008-3;H0YDX5 Q14008-2 CKAP5 Cytoskeleton-associated protein 5 0 7762600.0 1322300.0 2316000.0 4124300.0 False True 1811190.0438138796 2213671.462012172 3150225.282624764 1.0 1.2222193190454906 1.7393123893234506 20.788506502074462 -6.956980120537444 0.47609245887665513 0.9871202226483189 1.9958285113946528 0.9996412689344403 0.005866192957528653 0.08079809450482807 0.025255430027028476 0.007234071039745035 0.04266281020695204 1.1041291593236927e-07 6.956980120537444 1.008708288746334 VNDSWK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNDSWKER 8 1 P49454 P49454 CENPF Centromere protein F 1 4883960.0 618560.0 1145700.0 3119700.0 True False 938400.7427933513 941240.8836050425 2503089.927586914 1.0 1.0030265756218786 2.667399772229431 19.839844629772394 -6.907296230023828 0.9139545794581457 0.9439584021391852 2.870499047944482 0.9898605138960483 0.07907653962649172 0.106233087596619 0.14866831680330528 0.0638877038411497 0.17322289612183195 1.2379518978862794e-07 6.907296230023828 1.9265406458052965 up VNDTIQIDLETGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNDTIQIDLETGK 13 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 171290000.0 22488000.0 113250000.0 35552000.0 False True 34115940.093017526 93039652.6737113 28525131.61700488 1.0 2.7271607471474493 0.8361232766627787 25.023942635716228 -6.666377448294067 1.9501060075569396 2.105821950591747 0.8438485112554295 0.26322214924771015 0.7342714701239169 0.469440579504939 3.4381634007254482 0.30349956882008816 0.8147567614998078 2.1558699134674845e-07 6.666377448294067 -1.2619734393363173 VNDTIQIDLETGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNDTIQIDLETGK 13 0 P62701 P62701 RPS4X 40S ribosomal protein S4, X isoform 0 87185000.0 22488000.0 37535000.0 27162000.0 False True 29111159.30475133 35446144.254083246 22218794.705655348 1.0 1.2176136265482895 0.7632397759586629 24.795068957808677 -6.776462830034209 1.5495245306405443 1.1237852357475013 0.7600242155655393 0.7547051887289393 0.09189891250533871 0.2561165641990587 1.2143371638708593 0.04672300413619334 0.11058295479958165 1.6731588309309132e-07 6.776462830034209 -0.363761020181962 VNEFGESYEEK(ub)ATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNEFGESYEEKATR 14 1 Q96KA5;Q96KA5-2;G5E9Z2 Q96KA5 CLPTM1L Cleft lip and palate transmembrane protein 1-like protein 1 4956580.0 1086800.0 829680.0 3040100.0 True False 1488619.329665677 793021.9942151383 2322090.992824854 1.0 0.5327231605901825 1.559895768212524 20.505543443850463 -6.783007377057546 1.5239628069213196 0.7364476410114074 1.5688399452002384 0.7779361970783382 0.1978765789570978 0.24593668169330293 1.128316796878938 0.10224383325486543 0.24067259338537228 1.6481343955779442e-07 6.783007377057546 0.832392304188831 VNEFGESYEEK(ub)ATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNEFGESYEEKATR 14 1 Q96KA5;Q96KA5-2;G5E9Z2 Q96KA5 CLPTM1L Cleft lip and palate transmembrane protein 1-like protein 1 8652330.0 885530.0 2326900.0 5439900.0 True False 736357.4306305775 2314364.527846511 6577357.9387442535 1.0 3.142990661294219 8.932289761932262 19.490046700264585 -6.953780168272401 0.5156789437257638 0.8982354814478783 11.433501496754346 0.9994655086866464 0.07745927297688028 0.08200243499374044 0.029948424874347887 0.08836761183906712 0.47800984601588953 1.1122946074945943e-07 6.953780168272401 10.535266015306467 VNEIVETNRPDSK(ub)NWQYQETIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNEIVETNRPDSKNWQYQETIK 22 2 Q15008;Q15008-4;Q15008-3;Q15008-2 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 1 13674200.0 2202000.0 2477300.0 8994900.0 True False 2132098.715313861 3466498.8089488377 6638865.848784164 1.0 1.6258622473953053 3.1137703902264544 21.02384280516836 -6.956530742983534 0.48185172120408265 0.9649009935599819 3.8369602648059242 0.9996190813580923 0.01730274736888776 0.08096459596619737 0.02589404068908632 0.02105850702461188 0.12273243185502258 1.105272226232245e-07 6.956530742983534 2.8720592712459423 VNEIVETNRPDSK(ub)NWQYQETIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNEIVETNRPDSKNWQYQETIK 22 2 Q15008;Q15008-4;Q15008-3;Q15008-2 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 1 9362600.0 2587400.0 3151100.0 3624100.0 True False 3544031.7018558835 3011873.9827057663 2768162.220682396 1.0 0.8498439732151817 0.7810771611418735 21.756960078382374 -13.999999999999998 0.10496288526284198 1.7319633078750436 0.6452606015152823 0.999768661227799 0.0013903257159614268 12.044638466800917 0.097450444114189 1.887445491695525 0.12083468450202484 1.0000000000000041e-14 13.999999999999998 -1.0867027063597612 VNEIVETNRPDSK(ub)NWQYQETIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNEIVETNRPDSKNWQYQETIK 22 2 Q15008;Q15008-4;Q15008-3;Q15008-2 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 1 12268200.0 2202000.0 4382000.0 5684200.0 True False 1831060.565140121 4358393.2962411 6872739.939228671 1.0 2.380256218290396 3.7534203237579624 20.804248080602637 -6.971188887925668 0.22800930266702205 0.4274464166265662 5.745372153229063 0.9999902291248257 0.003513690585705795 0.07591878724581341 0.0076353578763909274 0.03580636226218092 0.13691517052124985 1.0685900157250991e-07 6.971188887925668 5.317925736602497 VNEIVETNRPDSK(ub)NWQYQETIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNEIVETNRPDSKNWQYQETIK 22 2 Q15008;Q15008-4;Q15008-3;Q15008-2 Q15008 PSMD6 26S proteasome non-ATPase regulatory subunit 6 1 42482500.0 5529700.0 6596800.0 30356000.0 True False 7158305.6566828275 6229682.280946756 24831519.47886292 1.0 0.8702732992591438 3.4689101960434994 22.771186716873636 -6.89515409697751 0.9914124788237384 0.8771297577434122 3.7163413172609285 0.9839967479886734 0.15124887598717887 0.11506011707917496 0.19822540699648297 0.11538405198614858 0.2935323971772925 1.2730512950227707e-07 6.89515409697751 2.8392115595175165 up VNELK(ub)LDDNEALIEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNELKLDDNEALIEK 15 1 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 1 21765100.0 11537000.0 6255700.0 3972400.0 True False 15125118.724466944 5322373.9445276065 3561374.1539514633 1.0 0.3518897300236024 0.23546090571774847 23.850443131063393 -13.999999999999998 0.24146772404227934 5.320581793706736 0.18469438669913674 0.9995274193108042 0.007311670956027357 13.675713646607726 0.1555202869334682 28.515894935066623 0.05640509801757548 1.0000000000000041e-14 13.999999999999998 -5.135887407007599 VNELK(ub)LDDNEALIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNELKLDDNEALIEK 15 1 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 1 32766600.0 14116000.0 8215600.0 10435000.0 True False 13667895.306707738 11496131.923788015 7701760.456710217 1.0 0.8411047689358657 0.5634927897735985 23.704287766383715 -6.9625995067653434 0.39710226210150457 1.0157570764044912 0.3787510967181946 0.9998547932724527 0.002173685181599804 0.07878525930986456 0.017793560301064312 0.0035739861552452692 0.023284976140412646 1.0899347348813384e-07 6.9625995067653434 -0.6370059796862966 VNELK(ub)LDDNEALIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNELKLDDNEALIEK 15 1 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 1 29933700.0 7562100.0 14643000.0 7728600.0 True False 11472258.563563135 12029842.24371882 6201038.822434285 1.0 1.048602781838148 0.5405246742022805 23.451646109417563 -6.883436205792806 1.0604015427734677 1.0317474367522539 0.502050899006628 0.9763550487662837 0.03520023127434851 0.12463192985732167 0.2542367350150193 0.025485838814024844 0.062208790527122915 1.307867639568636e-07 6.883436205792806 -0.5296965377456259 VNELK(ub)LDDNEALIEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNELKLDDNEALIEK 15 1 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 1 20767300.0 11537000.0 5862800.0 3367500.0 True False 15802540.675702004 5603762.110313023 2572165.8558395123 1.0 0.35461146566952817 0.16276913368712134 23.913653192586285 -13.999967024467443 0.17194595132924756 4.278446004800813 1.110235310152711e-06 0.9995073275237676 0.007949034384084284 12.152985960597698 0.13180333018765392 13.291024634817555 0.15247381653349495 1.0000759318523764e-14 13.999967024467443 -4.278444894565503 VNELK(ub)LDDNEALIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNELKLDDNEALIEK 15 1 P61011-2;P61011;G3V4F7 P61011-2 SRP54 Signal recognition particle 54 kDa protein 1 27206300.0 14116000.0 8712900.0 4377400.0 True False 11738079.444831029 8665961.878324762 5292694.101189195 1.0 0.7382776645067689 0.45089949561722226 23.48469304181799 -6.9699237622890635 0.26000129384540854 1.0806803749799208 0.09997070193516835 0.9999817811971894 0.0009571636420179393 0.07632745710924109 0.009118655153279328 0.005999039337367997 0.027114525092479674 1.071707420336882e-07 6.9699237622890635 -0.9807096730447524 down VNESSHYDLAFTDVHFK(ub)PGQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNESSHYDLAFTDVHFKPGQIR 22 1 A0A494C1B8;A0A494C0U1;Q5VZU9;P29144 A0A494C1B8 TPP2 Tripeptidyl-peptidase 2 1 42811400.0 16447000.0 9059400.0 17305000.0 True False 24951301.436759982 7442679.288584733 13884659.16494905 1.0 0.2982882198529197 0.5564703388374448 24.57261173137297 -10.301077847151465 5.679349468483777 1.00006143896655 0.4273792793455551 0.8677028490954163 0.10540240870379 8.200514830252179e-05 1.0091901820745048e-05 0.1020663264336662 0.03401848112999095 4.999449119740349e-11 10.301077847151465 -0.572682159620995 VNESSHYDLAFTDVHFK(ub)PGQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNESSHYDLAFTDVHFKPGQIR 22 1 A0A494C1B8;A0A494C0U1;Q5VZU9;P29144 A0A494C1B8 TPP2 Tripeptidyl-peptidase 2 1 37674000.0 16447000.0 10619000.0 10608000.0 True False 21290965.71883869 10028043.315148795 8677452.847271621 1.0 0.4709999277428629 0.40756501897861913 24.34373805346542 -13.999999999999998 0.2992187380837718 5.803768038040151 0.3918301501814069 0.9996480873235378 0.0049822958406307485 16.53764980674402 0.17369853636338262 49.16237738057034 0.02300216722498603 1.0000000000000041e-14 13.999999999999998 -5.411937887858745 VNFAMNVGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VNFAMNVGK 9 0 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 2354871530.0 513642820.0 569375910.0 1271852800.0 False True 673390711.1441438 484427243.6379144 1140253672.729535 1.0 0.7193850993501743 1.693301754626455 29.326868579642678 -6.829660355715911 1.3295346274210793 0.8500258674681258 1.7193078659158274 0.9051739884296548 0.12604698387949337 0.18123095859597277 0.6266687048161941 0.07444220724106772 0.17130525272879002 1.4802655919175902e-07 6.829660355715911 0.8692819984477016 VNFAMNVGK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VNFAMNVGK 9 0 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 1646965400.0 346660300.0 188451600.0 1111853500.0 False True 335655758.52875465 263701306.64211142 820625713.4599767 1.0 0.785630217690786 2.4448432437356087 28.322407152680764 -6.874430802181006 1.1104582558674314 0.8748334680618989 2.5505312293295765 0.9689054607940615 0.1299332774099301 0.13267414378787673 0.3031119000903236 0.09054517437960374 0.21616773452707466 1.3352703263977345e-07 6.874430802181006 1.6756977612676778 up VNFAMNVGK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VNFAMNVGK 9 0 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 3777832800.0 490788100.0 1347779000.0 1939265700.0 False True 744561429.116235 1107257307.2046096 1555968984.3846488 1.0 1.487126869463115 2.089779195561503 29.47181564057971 -6.968260788631813 0.2968049743336909 0.8914308501194337 2.704273429214313 0.9999654592754003 0.0026196269442751116 0.07687119144936269 0.011039501999864596 0.010160100391598089 0.05423507420335979 1.0758190032095959e-07 6.968260788631813 1.8128425790948794 VNFAMNVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VNFAMNVGK 9 0 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 2718523920.0 513642820.0 410467000.0 1794414100.0 False True 703550451.2292852 392331210.70714676 1370610446.6984382 1.0 0.5576447432044742 1.9481338464123306 29.39007864116557 -6.821138950679798 1.366967030128746 0.7618459975250778 1.9792311075622158 0.8869790504194558 0.1950037819891502 0.1920041766195021 0.7046729627789282 0.11209349548851001 0.25827871908565475 1.5095970876972313e-07 6.821138950679798 1.217385110037138 VNFAMNVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VNFAMNVGK 9 0 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 1204039800.0 346660300.0 271274500.0 586105000.0 False True 288263399.1051971 269813090.4247275 708656845.6566668 1.0 0.9359949659313619 2.4583656747836167 28.10281242811504 -6.897086541833209 0.9795176382016286 0.9315469799505665 2.609028858306112 0.9850597787388992 0.08593419092394404 0.1135812034017202 0.18976772908781195 0.06614350768747437 0.16970876771354457 1.2673992861194571e-07 6.897086541833209 1.6774818783555454 up VNFAMNVGK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VNFAMNVGK 9 0 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 0 4910088300.0 490788100.0 2981136800.0 1438163400.0 False True 635334870.329786 2815233916.450142 1176432418.0026264 1.0 4.431102475122807 1.8516729884383187 29.24294196267216 -6.573430179698543 2.292352244576759 3.3456252364310797 1.8573025736502728 0.0 1.49303868787863 0.7193923765578256 7.100762787546371 0.5491070147742523 1.6723917993300357 2.6703600388895085e-07 6.573430179698543 -1.4883226627808068 VNFAMNVGK(ub)AR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNFAMNVGKAR 11 1 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 66167200.0 1928600.0 6600600.0 57638000.0 True False 2925827.199546138 5422671.359276817 46245824.036367185 1.0 1.8533805961329488 15.806068124440488 21.48041313520538 -6.919409642482567 0.8291064689601302 0.6855217780789398 18.025691493811827 0.9940148651340347 0.5251019947063946 0.09852109607884207 0.10742855738906691 0.4510157498202069 1.343449338541304 1.2038998421685508e-07 6.919409642482567 17.340169715732888 up VNFAMNVGK(ub)AR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNFAMNVGKAR 11 1 P14618;P14618-3;P14618-2;B4DNK4;H3BR70 P14618 PKM Pyruvate kinase PKM;Pyruvate kinase 1 62183200.0 1928600.0 5541600.0 54713000.0 True False 2496610.718389513 5233205.088542101 44755795.40278777 1.0 2.096123776925015 17.926621508561958 21.25153945729783 -6.92089503948508 0.8180668596342954 0.661852361344613 20.5326887231988 0.994425841670061 0.577413995743362 0.09764795694872833 0.10290814712020233 0.4998733132331625 1.510400153574396 1.1997892337949978e-07 6.92089503948508 19.870836361854185 up VNFGTDFLTAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNFGTDFLTAIK 12 0 Q15813-2;Q15813;A0A2R8Y5Q8;A0A2R8YHI9;A0A2R8YFL4;A0A2U3TZJ6;A0A2R8Y4V6;A0A2R8Y809;A0A2R8YER9;A0A2R8YFM3;A0A2R8Y784;A0A2R8Y7H8;A0A2R8Y4P2;A0A2R8Y6G3;A0A2R8Y787;A0A2R8Y5H6 Q15813-2 TBCE Tubulin-specific chaperone E 0 3520590.0 838190.0 1423300.0 1259100.0 False True 1098875.2070435074 1210949.1879799468 1128820.4101400403 1.0 1.1019897256923026 1.0272507768894883 20.067596126310104 -10.49465456178099 4.577523099184631 0.9996858491595396 1.064620251290925 0.4991837548329088 0.030512048079916098 9.829775664474982e-05 1.0851811761056935e-05 0.029686496603541637 0.009847721172668703 3.201440525899278e-11 10.49465456178099 0.06493440213138546 VNFGTDFLTAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNFGTDFLTAIK 12 0 Q15813-2;Q15813;A0A2R8Y5Q8;A0A2R8YHI9;A0A2R8YFL4;A0A2U3TZJ6;A0A2R8Y4V6;A0A2R8Y809;A0A2R8YER9;A0A2R8YFM3;A0A2R8Y784;A0A2R8Y7H8;A0A2R8Y4P2;A0A2R8Y6G3;A0A2R8Y787;A0A2R8Y5H6 Q15813-2 TBCE Tubulin-specific chaperone E 0 4211390.0 838190.0 1405500.0 1967700.0 False True 1148091.4942330464 1343400.3626330367 1502969.786053573 1.0 1.1701161182545485 1.3091027967745672 20.130806187832995 -6.973432031050095 0.15571793411221302 0.8507888329667056 1.632103761767194 0.9999982812494457 0.00016561622815502365 0.07520399870671647 0.0047862553287743356 0.0067044167540011405 0.016949834191649003 1.06308494761281e-07 6.973432031050095 0.7813149288004885 VNFHMFDVGGQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNFHMFDVGGQR 12 0 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;P38405;P38405-2;A0A590UJQ9;K7EPE2;K7EQ80;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;P63092-3;A0A590UJF0;A0A590UJG5 P63092;P63092-2;P63092-3 GNAS;GNAL Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha 0 13703200.0 4138600.0 3148700.0 6415900.0 False True 5425744.67825941 2678926.2335364707 5752044.21365855 1.0 0.4937435121617031 1.0601391246268186 22.371389728983083 -6.670991554149134 1.9339577300669162 0.6771540621680379 1.0578626702100267 0.2836442241411351 0.21499341102668323 0.4586943443454861 3.30850019566437 0.08946904696663076 0.2387215497608527 2.1330863954935892e-07 6.670991554149134 0.3807086080419888 VNFHMFDVGGQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNFHMFDVGGQR 12 0 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;P38405;P38405-2;A0A590UJQ9;K7EPE2;K7EQ80;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;P63092-3;A0A590UJF0;A0A590UJG5 P63092;P63092-2;P63092-3 GNAS;GNAL Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha 0 12390500.0 4138600.0 2506200.0 5745700.0 False True 5668752.261459671 2395467.797104885 4388683.996405959 1.0 0.422574084493166 0.7741887092585518 22.434599790505974 -10.334975729133404 6.385351267513543 1.00002277195151 0.5983813968758833 0.634974199691775 0.1435460694625616 4.653756754009676e-05 4.8468062191074696e-06 0.1389957480794033 0.04632929470350282 4.6240686262484786e-11 10.334975729133404 -0.4016413750756267 VNFHMFDVGGQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNFHMFDVGGQR 12 0 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJY2;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;P38405;P38405-2;A0A590UJQ9;K7EPE2;K7EQ80;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;P63092-3;A0A590UJF0;A0A590UJG5 P63092;P63092-2;P63092-3 GNAS;GNAL Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;Guanine nucleotide-binding protein G(olf) subunit alpha 0 7416900.0 3042600.0 1461700.0 2912600.0 False True 2530056.7100342074 1453825.5319752663 3521611.193659168 1.0 0.5746217174537601 1.3919099835558841 21.270738291938695 -6.7652584042541 1.5924640364290945 0.7545332956487795 1.395717528694174 0.7120970072255914 0.17907875852518157 0.2741941693124311 1.3714707513575735 0.08867600706871377 0.21202912557605813 1.7168865395037394e-07 6.7652584042541 0.6411842330453946 VNFLPEIITLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNFLPEIITLSK 12 0 Q14204 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 2590400.0 912820.0 546680.0 1130900.0 False True 759050.2747825627 543734.9263325165 1367365.9613091925 1.0 0.7163358533639614 1.8014168583245525 19.53383591841408 -6.837246270582056 1.295082623920857 0.8490020760499064 1.835213409778963 0.9196250320084566 0.13026609470613484 0.17203653044136347 0.5616840616314678 0.07890538009831513 0.18167463352402868 1.4546339834147604e-07 6.837246270582056 0.9862113337290566 VNFTVDQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNFTVDQIR 9 0 P13639 P13639 EEF2 Elongation factor 2 0 117307000.0 25667000.0 41318000.0 50322000.0 False True 33649685.559581555 35153515.45630252 45115162.16270918 1.0 1.0446907562942371 1.3407305718452067 25.00408968780636 -6.933777699221703 0.7150970873422986 0.9960675732518594 1.407799477103258 0.9972301436969926 0.007957203284470325 0.09072292427449202 0.06841316703495308 0.00741982810215152 0.026252282725055344 1.1647220590089093e-07 6.933777699221703 0.4117319038513987 VNFTVDQIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNFTVDQIR 9 0 P13639 P13639 EEF2 Elongation factor 2 0 68654000.0 19037000.0 12604000.0 37013000.0 False True 18432680.85532695 17636842.92899169 27318184.93380117 1.0 0.9568246240152708 1.4820516423093364 24.135762576494066 -6.886967246852293 1.040191008410944 0.9696930240139447 1.5246248710456818 0.9788837794308896 0.03459513723940029 0.1216368493288227 0.23651537630539674 0.025437289845747866 0.06275926457707773 1.2972771039249306e-07 6.886967246852293 0.554931847031737 VNFTVDQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNFTVDQIR 9 0 P13639 P13639 EEF2 Elongation factor 2 0 121150000.0 25667000.0 33644000.0 61839000.0 False True 35156783.524594136 32157496.83416991 47233901.814182475 1.0 0.9146882510362173 1.3435217070167902 25.06729974932925 -6.854996501524115 1.210688719346064 0.9541972547576696 1.3623952518399778 0.947270234300294 0.04256128583081839 0.15204675765688563 0.4263578928474673 0.027468422944249678 0.06380298893349164 1.396379609600225e-07 6.854996501524115 0.4081979970823082 VNFTVDQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNFTVDQIR 9 0 P13639 P13639 EEF2 Elongation factor 2 0 48031000.0 19037000.0 15539000.0 13455000.0 False True 15830108.982094666 15455288.322750002 16268378.291109 1.0 0.9763222944473332 1.0276858049120228 23.916167851928343 -6.781301801643802 1.5303574493626246 0.9866165648098998 1.0281128655554128 0.7721715907072468 0.0100189744235674 0.24852401095167437 1.1496526533058935 0.005155567722852675 0.012154055056430465 1.6546197289486882e-07 6.781301801643802 0.041496300745513026 VNFTVDQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNFTVDQIR 9 0 P13639 P13639 EEF2 Elongation factor 2 0 58708000.0 19146000.0 23604000.0 15958000.0 False True 24784874.424082577 22290416.650416426 13053807.742907306 1.0 0.8993556420345477 0.5266844414681959 24.562956613428803 -6.946649780209832 0.5944883112437102 1.0042537393056135 0.402888921024887 0.9989114548572054 0.006717070900716333 0.08485958638722707 0.0417496842778673 0.006932021545657776 0.0312633910663004 1.1307073618281928e-07 6.946649780209832 -0.6013648182807265 VNGK(ub)AGNLGGGVVTIER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNGKAGNLGGGVVTIER 17 1 P35268;K7ERI7;K7EMH1;K7ELC4;K7EP65;K7EKS7;K7EJT5 P35268 RPL22 60S ribosomal protein L22 1 59515300.0 20373000.0 32163000.0 6979300.0 True False 26709200.292412672 27364405.77039207 6257148.986172962 1.0 1.0245310780856858 0.2342694246802455 24.670833444698136 -6.899734150853064 0.9629269401223228 1.0330962943373903 0.15175871984789746 0.9864341623091153 0.04273230629957706 0.11160192296270437 0.17851685251695906 0.03329935923795875 0.0865261778459725 1.259696286669377e-07 6.899734150853064 -0.8813375744894928 down VNGK(ub)AGNLGGGVVTIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNGKAGNLGGGVVTIER 17 1 P35268;K7ERI7;K7EMH1;K7ELC4;K7EP65;K7EKS7;K7EJT5 P35268 RPL22 60S ribosomal protein L22 1 66259000.0 25626000.0 30240000.0 10393000.0 True False 24812516.656963184 42314989.699516736 7670761.51668321 1.0 1.7053888682283986 0.30914887122224055 24.564564734967288 -6.769353074860805 1.5768896128458063 1.4049269831649072 0.30147942374745085 0.728092591524777 0.29723696400257477 0.2674779123892747 1.3125050871852197 0.1485844919933642 0.3539089004748394 1.7007752415748676e-07 6.769353074860805 -1.1034475594174564 VNGK(ub)AGNLGGGVVTIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNGKAGNLGGGVVTIER 17 1 P35268;K7ERI7;K7EMH1;K7ELC4;K7EP65;K7EKS7;K7EJT5 P35268 RPL22 60S ribosomal protein L22 1 82055000.0 36731000.0 20695000.0 24629000.0 True False 55723612.39579442 17001815.559226982 19761067.354725815 1.0 0.3051097161193761 0.35462645914566054 25.73178545080413 -10.094691024085407 7.793731153879137 1.0000000589420899 0.3298680876325184 0.9959217854133827 0.02021512568981906 2.070167270023546e-08 2.3950623731492017e-09 0.01957321303449906 0.006524403761513238 8.040979888910313e-11 10.094691024085407 -0.6701319713095715 VNGK(ub)AGNLGGGVVTIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNGKAGNLGGGVVTIER 17 1 P35268;K7ERI7;K7EMH1;K7ELC4;K7EP65;K7EKS7;K7EJT5 P35268 RPL22 60S ribosomal protein L22 1 45221600.0 20373000.0 16876000.0 7972600.0 True False 27905448.659623545 16130362.518530846 6089636.080851099 1.0 0.5780363080802174 0.2182239087114986 24.734043506221028 -7.808989163020802 0.31688978646824145 1.0962809369785675 1.2647466144454392e-10 0.9992310974869469 0.008859297839046579 0.11685095991663598 0.0515257311005508 0.04069233303837678 0.08223852281077643 1.5524257472580768e-08 7.808989163020802 -1.096280936852093 down VNGK(ub)AGNLGGGVVTIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNGKAGNLGGGVVTIER 17 1 P35268;K7ERI7;K7EMH1;K7ELC4;K7EP65;K7EKS7;K7EJT5 P35268 RPL22 60S ribosomal protein L22 1 80905600.0 25626000.0 50868000.0 4411600.0 True False 21309154.42428732 50593963.9874925 5334045.163066259 1.0 2.3742830419318532 0.25031707297529965 24.344970010401564 -6.732025726302261 1.7157525759744072 1.8251622978609852 0.25108680587996807 0.5686662953114675 0.5776298650415993 0.33245714209905297 1.9182295270308256 0.26668731087294073 0.6602772691145449 1.8534218290138564e-07 6.732025726302261 -1.5740754919810171 VNGK(ub)AGNLGGGVVTIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNGKAGNLGGGVVTIER 17 1 P35268;K7ERI7;K7EMH1;K7ELC4;K7EP65;K7EKS7;K7EJT5 P35268 RPL22 60S ribosomal protein L22 1 103232000.0 36731000.0 38207000.0 28294000.0 True False 47549003.576254874 36080746.86334776 23144782.320956215 1.0 0.7588118393582036 0.4867564108643973 25.502911772896578 -6.969561796785148 0.2684533278889864 1.0689117056883801 0.16849468900382228 0.9999787568202431 0.000966299085540356 0.07644520036737085 0.009538147398516543 0.00538385450017217 0.025356906894302977 1.0726010140508433e-07 6.969561796785148 -0.9004170166845579 down VNGK(ub)DASSTYSQVENLNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNGKDASSTYSQVENLNR 18 1 Q9UFC0;H7C5S6 Q9UFC0 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 1 3198200.0 2145000.0 0.0 1053200.0 True False 1783662.539611971 0.0 1273419.2505534026 1.0 0.0 0.7139350758750757 20.766411259425176 -10.590078024145157 8.749720512988187 1.0001665444539762 0.3569675399591749 0.5196120409385727 0.29146277422818795 0.0009471463124853649 4.43733579665525e-05 0.2822775272040112 0.09406920588543204 2.5699340340529387e-11 10.590078024145157 -0.6431990044948013 VNGLEEGVEFLPVNNVK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNGLEEGVEFLPVNNVKK 18 1 Q9Y5Y6 Q9Y5Y6 ST14 Suppressor of tumorigenicity 14 protein 1 27806700.0 9579400.0 12033000.0 6194300.0 True False 7965695.539374773 11968175.840636509 7489499.490792755 1.0 1.5024646349433397 0.9402191502012397 22.925368908149004 -6.671059602921928 1.9334821777067748 1.3204280816552383 0.9424754789882355 0.28378156739329896 0.21338403604161513 0.45870537698001596 3.3069479655484986 0.08881311438373052 0.2369706253091983 2.132752192444333e-07 6.671059602921928 -0.3779526026670028 VNHFIAEFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNHFIAEFK 9 0 A8K7Q2 A8K7Q2 HSPA8 0 305057300.0 99906000.0 83715000.0 121436300.0 False True 130977733.4910803 71225048.3185141 108871236.57524325 1.0 0.543795089593336 0.8312194269467755 26.96474633030896 -10.500261242580002 6.0281392363459565 1.0003036303099495 0.6875072582700563 0.6118096167369624 0.11734049436225043 0.0004792831101746393 3.973288622893424e-05 0.11372280936568141 0.03787148170839508 3.160376016953816e-11 10.500261242580002 -0.3127963720398932 VNHFIAEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNHFIAEFK 9 0 A8K7Q2 A8K7Q2 HSPA8 0 179394500.0 48848000.0 32989500.0 97557000.0 False True 47297346.978043325 46162379.387969784 72003895.05273402 1.0 0.9760035675869849 1.5223664677462803 25.49525592581077 -6.896627917579084 0.9823392259324052 0.9751341790572821 1.5759457859161998 0.9848122067668718 0.03106754932456953 0.11393128208975788 0.19175004294855033 0.023861903454234938 0.06109813443759401 1.2687383937896916e-07 6.896627917579084 0.6008116068589178 VNHFIAEFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNHFIAEFK 9 0 A8K7Q2 A8K7Q2 HSPA8 0 76796800.0 11436500.0 36728300.0 28632000.0 False True 17350006.620143853 30173847.905482337 22972872.65014861 1.0 1.7391260168425318 1.3240843737475265 24.04843287749616 -10.10984011895486 4.283580771765684 0.9999213452173438 1.5316051953401837 0.6862674495647779 0.16944004147332828 52471031.92937527 67223828.88568161 52012.580004496485 0.06200871055419482 7.765329366256377e-11 10.10984011895486 0.5316838501228399 VNHFIAEFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNHFIAEFK 9 0 A8K7Q2 A8K7Q2 HSPA8 0 289142000.0 99906000.0 62500000.0 126736000.0 False True 136843948.0581332 59738543.3401386 96803567.00985192 1.0 0.43654501487169045 0.7074011557217599 27.02795639183185 -10.454963630633864 6.1847709405937605 1.0001821989961597 0.571973085296733 0.7690364670725129 0.11057655646368027 0.00027791788661495135 2.4491385038133406e-05 0.10711014041676724 0.0356884301387331 3.507812483932195e-11 10.454963630633864 -0.4282091136994267 VNHFIAEFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNHFIAEFK 9 0 A8K7Q2 A8K7Q2 HSPA8 0 117363900.0 48848000.0 30240600.0 38275300.0 False True 40619276.333317235 30077687.88551087 46278488.26500821 1.0 0.7404781818045385 1.1393233076151361 25.275661201245047 -6.731091779159219 1.7191380252957007 0.8440105807736934 1.1391381088014962 0.5643438850880729 0.10908798481234956 0.33420799563416725 1.9355272940127553 0.05027415935626109 0.12460332161466751 1.8574118880142582e-07 6.731091779159219 0.29512752802780284 VNHFIAEFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNHFIAEFK 9 0 A8K7Q2 A8K7Q2 HSPA8 0 59258800.0 11436500.0 42401000.0 5421300.0 False True 14804774.697117958 40041347.076525494 4434679.027235452 1.0 2.704623872751021 0.2995438375768562 23.81955919958861 -6.716318117113632 1.7724009593193693 2.0411365690637027 0.3040119148818788 0.4951102295061033 0.7176572721059349 0.3625475021678588 2.223701634750881 0.3217443210998136 0.8112670757875382 1.9216835959207043e-07 6.716318117113632 -1.737124654181824 VNHFIAEFK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNHFIAEFKR 10 1 A8K7Q2 A8K7Q2 HSPA8 1 18393800.0 7340000.0 5236400.0 5817400.0 True False 7106995.717712876 7327321.82746525 4293648.421740879 1.0 1.0310013004796459 0.6041439438382877 22.760808399334568 -6.889437301537819 1.0257309845394638 1.0232459895719095 0.5678358868641323 0.9805347675595675 0.027112223789979874 0.11959986043371858 0.2245364996955368 0.02015499740854149 0.050144836529765605 1.289919768296271e-07 6.889437301537819 -0.45541010270777715 VNHFIAEFK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNHFIAEFKR 10 1 A8K7Q2 A8K7Q2 HSPA8 1 15969770.0 5103200.0 5960770.0 4905800.0 True False 6989990.948794521 5697403.471769557 3747151.0781224845 1.0 0.815080235941095 0.5360738097620441 22.736859156807903 -6.965159915300877 0.3552981608195166 1.0253709771672626 0.3162912680208446 0.9999164019840172 0.00174351517894827 0.0779067570346493 0.014668907041464332 0.0037812874188529124 0.023899473842304036 1.0835278654565502e-07 6.965159915300877 -0.7090797091464179 VNHFIAEFK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNHFIAEFKR 10 1 A8K7Q2 A8K7Q2 HSPA8 1 15439900.0 7340000.0 4965100.0 3134800.0 True False 6103535.217133742 4938352.020804811 3790272.18632245 1.0 0.8090969979073689 0.6209962016246685 22.541213674768844 -6.971307393413346 0.22478122265190822 1.081673117802819 0.3430788108207746 0.9999908602027534 0.00046774278121130663 0.07588078865933053 0.0074942298849583686 0.0050246378032120734 0.018876801506752267 1.0682984704474728e-07 6.971307393413346 -0.7385943069820443 VNHVTLSQPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNHVTLSQPK 10 0 P61769;F5H6I0;H0YLF3 P61769 B2M Beta-2-microglobulin;Beta-2-microglobulin form pI 5.3 0 15174200.0 1363600.0 8123700.0 5686900.0 False True 1787692.8051211839 6911675.625934586 5098474.140596769 1.0 3.8662546530001043 2.8519856017718626 20.769667416245543 -10.279115729239576 5.935545919655496 0.9998758658393094 3.359120127385977 0.8782458912059409 0.4140736062343626 0.0006802521776484581 8.261761955393429e-05 0.4009449763262671 0.1336416817541403 5.258771138662165e-11 10.279115729239576 2.3592442615466678 VNHVTLSQPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNHVTLSQPK 10 0 P61769;F5H6I0;H0YLF3 P61769 B2M Beta-2-microglobulin;Beta-2-microglobulin form pI 5.3 0 10927800.0 5102900.0 1283100.0 4541800.0 False True 4940911.232686245 1795448.5212781043 3352166.3289206005 1.0 0.36338408781773757 0.6784510328266138 22.236345706203764 -10.55262199887878 6.464707917134873 1.0006141043117864 0.520917560322274 0.7550735446216923 0.12862554168154566 0.0011398299680180615 7.887958044247412e-05 0.12469032811710704 0.04151371506912785 2.801418556793864e-11 10.55262199887878 -0.47969654398951245 VNHVTLSQPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNHVTLSQPK 10 0 P61769;F5H6I0;H0YLF3 P61769 B2M Beta-2-microglobulin;Beta-2-microglobulin form pI 5.3 0 40352540.0 994640.0 38144000.0 1213900.0 False True 1508941.5979241768 31336905.1795677 973972.1329287305 1.0 20.7674738523196 0.6454670838610361 20.52510553820025 -6.455828155727528 2.8524053691090647 9.999999999999998 0.5774212457861385 0.2569798887215874 8.105389093977703 0.6424463794041586 9.705396817375698 3.150066129125643 11.469110197895578 3.500836628513796e-07 6.455828155727528 -9.422578754213859 VNHVTLSQPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNHVTLSQPK 10 0 P61769;F5H6I0;H0YLF3 P61769 B2M Beta-2-microglobulin;Beta-2-microglobulin form pI 5.3 0 14884000.0 1363600.0 6864700.0 6655700.0 False True 1867759.7699044137 6561394.85547279 5083760.738444258 1.0 3.5129757912114052 2.7218493621930993 20.832877477768434 -9.98052154272117 5.64030538212738 0.999996236123035 3.1174125767039045 0.9052240478911262 0.32297601219333827 1.5286321277188144e-05 2.762747495892661e-06 0.3127207282066357 0.10424005970325831 1.0458718098049091e-10 9.98052154272117 2.1174163405808697 VNHVTLSQPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNHVTLSQPK 10 0 P61769;F5H6I0;H0YLF3 P61769 B2M Beta-2-microglobulin;Beta-2-microglobulin form pI 5.3 0 6502260.0 5102900.0 903910.0 495450.0 False True 4243287.446799969 899040.4574179134 599046.3042980278 1.0 0.2118735694174844 0.14117504689666788 22.01675098163804 -13.973181100525217 0.3413488617166646 9.999999999999817 0.13019714787622624 0.9997369841680639 0.006312950863496561 19.449376778516303 0.18733063314897364 126.28901662555285 0.021750974165443745 1.063699363764692e-14 13.973181100525217 -9.869802852123591 VNIAFNYDMPEDSDTYLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNIAFNYDMPEDSDTYLHR 19 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;H0Y400 Q13838-2 DDX39B Spliceosome RNA helicase DDX39B 0 12740500.0 3051500.0 6051000.0 3638000.0 False True 4000546.0507680397 5148214.386613265 3261574.658160167 1.0 1.2868779214839663 0.8152823681492174 21.93176550206635 -6.742056908999648 1.6792874449996722 1.170282417565121 0.8148857388189422 0.6141162905801271 0.12052932136202937 0.31409363895832987 1.7399570465255325 0.056764177802765485 0.13897434837304753 1.8111027541235076e-07 6.742056908999648 -0.35539667874617875 VNIAFNYDMPEDSDTYLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNIAFNYDMPEDSDTYLHR 19 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;H0Y400 Q13838-2 DDX39B Spliceosome RNA helicase DDX39B 0 59809000.0 18690000.0 10078000.0 31041000.0 False True 18096696.180388756 14102197.956075698 22910430.88996091 1.0 0.7792692000520037 1.2660007474065216 24.10922300023651 -6.783382555862537 1.5223836392857883 0.8755660268276321 1.2702948048727731 0.7792742945325937 0.09349008819923918 0.24535421584566075 1.123309779079293 0.04835479655568236 0.1137935188649712 1.6467112182010256e-07 6.783382555862537 0.39472877804514106 VNIAFNYDMPEDSDTYLHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNIAFNYDMPEDSDTYLHR 19 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;H0Y400 Q13838-2 DDX39B Spliceosome RNA helicase DDX39B 0 169656000.0 44194000.0 72444000.0 53018000.0 False True 67045529.01417709 59515802.19244452 42538969.06138509 1.0 0.887692334858893 0.6344788338144073 25.998637792252687 -6.957635586811425 0.46757106473403953 1.006848379006378 0.504984718028781 0.9996721869987591 0.0027678815364218607 0.08055686966120228 0.024336383821834916 0.003485320583254552 0.020902942912603764 1.1024639906697771e-07 6.957635586811425 -0.501863660977597 VNIAFNYDMPEDSDTYLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNIAFNYDMPEDSDTYLHR 19 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;H0Y400 Q13838-2 DDX39B Spliceosome RNA helicase DDX39B 0 12797000.0 3051500.0 4092600.0 5652900.0 False True 4179722.0136868036 3911775.399581616 4317801.445129972 1.0 0.9358936758885454 1.0330355537978404 21.994975563589243 -6.728730732070414 1.7278801190569715 0.9613668345113107 1.0329643291036195 0.5533758608673168 0.026951533658256418 0.338615548899336 1.9799820454819466 0.012363878036814643 0.030724048474073277 1.8675372280446515e-07 6.728730732070414 0.0715974945923088 VNIAFNYDMPEDSDTYLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNIAFNYDMPEDSDTYLHR 19 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;H0Y400 Q13838-2 DDX39B Spliceosome RNA helicase DDX39B 0 37071100.0 18690000.0 12537000.0 5844100.0 False True 15541563.107388211 12469460.692600342 7066074.2899346035 1.0 0.802329894775678 0.45465660314280126 23.889628275670788 -6.962477642415908 0.3989846542902949 1.01932739724707 0.2249850718390567 0.9998513362015793 0.002748555784036508 0.07882767797062754 0.01794626656432008 0.004474189862040276 0.029140423447558926 1.0902406167889085e-07 6.962477642415908 -0.7943423254080133 down VNIAFNYDMPEDSDTYLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNIAFNYDMPEDSDTYLHR 19 0 Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;H0Y400 Q13838-2 DDX39B Spliceosome RNA helicase DDX39B 0 113253000.0 44194000.0 40519000.0 28540000.0 False True 57210004.19397806 38264082.0309364 23346012.845129382 1.0 0.668835504734399 0.4080757058847898 25.769764114345136 -7.543391463732955 0.1907110525346386 1.2189172849702952 7.276538026794866e-15 0.9999535589681547 0.0016506706001309123 0.13147174048632762 0.018886563725591807 0.03667004201893266 0.06997945979143196 2.861597424502949e-08 7.543391463732955 -1.2189172849702878 down VNIEGGAIALGHPLGASGCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNIEGGAIALGHPLGASGCR 20 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 85606000.0 21447000.0 31019000.0 33140000.0 False True 28117224.693043463 26391086.11111501 29710990.701327056 1.0 0.9386092119413364 1.0566829061432195 24.744950864625544 -6.765411317912623 1.5921153951361573 0.9645819600603073 1.057233489245898 0.7126745068274114 0.025845184840816722 0.2739106401712386 1.3695184931807596 0.01280132433561089 0.03060133479161053 1.7162821358111747e-07 6.765411317912623 0.09265152918559083 VNIEGGAIALGHPLGASGCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNIEGGAIALGHPLGASGCR 20 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 29614200.0 14070000.0 5695000.0 9849200.0 False True 13623355.551528605 7969043.199032656 7269399.050333534 1.0 0.5849545047026605 0.5335982770792379 23.699578759727885 -13.999999999999998 0.294702728097708 4.67294589743664 0.520255005220244 0.9996379897788665 0.00397301534038257 16.251604590948382 0.17226434493229414 36.2875110058508 0.018993130898149826 1.0000000000000041e-14 13.999999999999998 -4.152690892216396 VNIEGGAIALGHPLGASGCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNIEGGAIALGHPLGASGCR 20 0 Q9BWD1;Q9BWD1-2 Q9BWD1 ACAT2 Acetyl-CoA acetyltransferase, cytosolic 0 76761000.0 21447000.0 22652000.0 32662000.0 False True 29376535.483382225 21651159.739853106 24947908.29500525 1.0 0.7370222316413307 0.8492461035481135 24.808160926148435 -10.111990761245501 4.623244678268567 1.0000158676989352 0.7931341675911336 0.8191843952515172 0.04581520387018029 11040770.347661689 24148444.953420117 1105.9139622231346 0.01568376314957358 7.726970225188329e-11 10.111990761245501 -0.2068817001078016 VNIFGVESGK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNIFGVESGKK 11 1 H0YN81;Q9GZS3;H0YMF9;H0YL19 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 1 36567300.0 13627100.0 19482900.0 3457300.0 True False 17865260.065024123 16576127.263749378 3099571.7607633704 1.0 0.9278413638210307 0.1734971531050693 24.090653579634285 -6.925483270381639 0.7829919785516843 1.013593239532994 0.03506571051908796 0.9955732195426449 0.024868560562131027 0.09505250373242909 0.08967786739728927 0.02207450777911307 0.07002698965769386 1.1871804319792832e-07 6.925483270381639 -0.9785275290139062 down VNIFGVESGK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNIFGVESGKK 11 1 H0YN81;Q9GZS3;H0YMF9;H0YL19 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 1 42753400.0 18724000.0 11012100.0 13017300.0 True False 28405676.907757916 9046904.717069998 10444424.94931472 1.0 0.31848931980913947 0.3676879443229261 24.75967594704784 -10.075832168531957 7.732710752078408 1.000000046901232 0.34308863206603285 0.9958108057287057 0.020085254350926927 1.6249898893605847e-08 1.9487436598420095e-09 0.019447465060515434 0.006482487967123336 8.397844553626837e-11 10.075832168531957 -0.6569114148351991 VNIFGVESGK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNIFGVESGKK 11 1 H0YN81;Q9GZS3;H0YMF9;H0YL19 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 1 26729900.0 13627100.0 13102800.0 0.0 True False 18665407.12853069 12523874.970834682 0.0 1.0 0.6709671471184535 0.0 24.153863641157177 -7.488609882224203 0.7201490093615491 0.9927424094154431 4.1874570817500494e-17 0.9871101017878917 0.047244499295814237 0.11850340796305919 0.14193458532519984 0.041618613655423416 0.07530002501702605 3.2463109583308494e-08 7.488609882224203 -0.9927424094154431 down VNIFGVESGK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNIFGVESGKK 11 1 H0YN81;Q9GZS3;H0YMF9;H0YL19 H0YN81 WDR61 WD repeat-containing protein 61;WD repeat-containing protein 61, N-terminally processed 1 44511000.0 18724000.0 10655700.0 15131300.0 True False 24238587.105218954 10062700.927886901 12377558.660248972 1.0 0.41515212434639975 0.5106551222032197 24.53080226914029 -10.824343209484335 7.371329402669416 1.0272413206168052 0.4629036232748146 0.976836055396124 0.03898893560922073 0.015110349656342592 0.0003600750631935532 0.032680170208851674 0.01258362485840543 1.498500149175635e-11 10.824343209484335 -0.5643376973419906 VNIHAIITLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNIHAIITLK 10 0 Q9H9A6 Q9H9A6 LRRC40 Leucine-rich repeat-containing protein 40 0 30996600.0 6085600.0 13025000.0 11886000.0 False True 9232300.116954265 10700586.985210508 9536726.890181128 1.0 1.1590380349052853 1.0329740984771294 23.13825869215983 -10.435609502558961 4.7140772940529825 0.9997902421377298 1.096006066691245 0.43608321962633645 0.05146538653606931 0.00011370445476375692 1.3613147616610977e-05 0.04993976955098865 0.016610382080008628 3.6676720647995245e-11 10.435609502558961 0.09621582455351518 VNIHAIITLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNIHAIITLK 10 0 Q9H9A6 Q9H9A6 LRRC40 Leucine-rich repeat-containing protein 40 0 22078900.0 6085600.0 9563600.0 6429700.0 False True 7877929.165110047 9031377.252919959 5259560.574293209 1.0 1.1464151382470318 0.6676323769940546 22.90938501425228 -6.824640371283316 1.3517714509072625 1.078567348751296 0.6561104999953821 0.8947068449277988 0.06500035755728918 0.187519456214227 0.672000889915471 0.03777467760988709 0.08697171455272888 1.4974751656487665e-07 6.824640371283316 -0.4224568487559138 VNIIPLIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNIIPLIAK 9 0 E7ES33;E7EPK1;Q16181-2;Q16181;G3V1Q4;A0A0U1RRE1;A0A0U1RRH9;Q6ZU15 E7ES33 SEPT7;SEPT14 Septin-7;Septin-14 0 4966120.0 3038100.0 796820.0 1131200.0 False True 2941657.1784718633 1114994.3813614068 834904.7847274186 1.0 0.3790361397382906 0.28382123887091976 21.488197693640547 -13.999999999999998 0.2639879707710048 5.64184824029937 0.2503275606332021 0.9995705739782775 0.006580574080725401 14.59712791540488 0.1626066195092507 36.23312743238923 0.040770271472442415 1.0000000000000041e-14 13.999999999999998 -5.391520679666168 VNIIQFGTGYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNIIQFGTGYK 11 0 Q9UKK3 Q9UKK3 PARP4 Poly [ADP-ribose] polymerase 4 0 4901200.0 1751600.0 1356100.0 1793500.0 False True 2296364.5625185305 1153775.1660363972 1607925.8244668085 1.0 0.5024355387068846 0.7002049459878971 21.13092026655825 -10.175918638340443 5.365594175527587 1.0000150986469896 0.6013202423472931 0.8441972704442151 0.08073902242886873 1.4583324866761089e-05 2.2398329243597486e-06 0.07817817961789798 0.0260584074379566 6.669317019259076e-11 10.175918638340443 -0.3986948562996965 VNIISVTNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNIISVTNK 9 0 Q9BY44;Q9BY44-3;Q9BY44-4;C9IZE1;H7C5Q3 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 22138500.0 6954000.0 6135000.0 9049500.0 False True 9116761.342631783 5219681.914042696 8113144.548933601 1.0 0.5725368601714327 0.8899152060715826 23.120089978720586 -10.27734529316814 5.740279772183539 1.0000191049983838 0.7312260331215052 0.4888104722458989 0.12956916714399408 3.1682205045003396e-05 3.988364640022194e-06 0.12546371614851812 0.04181826887755316 5.280252694253038e-11 10.27734529316814 -0.2687930718768785 VNIISVTNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNIISVTNK 9 0 Q9BY44;Q9BY44-3;Q9BY44-4;C9IZE1;H7C5Q3 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 14473700.0 3316700.0 1985200.0 9171800.0 False True 3211413.173969789 2777900.7126812376 6769430.431897931 1.0 0.8650088176749101 2.1079288354322525 21.614776860575994 -6.879993052354297 1.079807004708846 0.9163369672564758 2.1960129919862625 0.973681163365364 0.09033566725457133 0.1276376623702248 0.27230621233624 0.06444349170218283 0.15584213001703018 1.3182778275971538e-07 6.879993052354297 1.2796760247297867 up VNIISVTNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNIISVTNK 9 0 Q9BY44;Q9BY44-3;Q9BY44-4;C9IZE1;H7C5Q3 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 19618900.0 4697800.0 11073000.0 3848100.0 False True 7126906.055183988 9096936.636256125 3087521.3483178522 1.0 1.2764215728140784 0.4332204359663255 22.764844476627328 -6.818394862402418 1.3787672744322705 1.149239301830589 0.4154342141062302 0.8806489883992794 0.12125127345640489 0.19558372074461128 0.7310004090657505 0.06911351361438983 0.15937066296898347 1.5191656696998201e-07 6.818394862402418 -0.7338050877243589 down VNIISVTNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNIISVTNK 9 0 Q9BY44;Q9BY44-3;Q9BY44-4;C9IZE1;H7C5Q3 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 26532100.0 6954000.0 8609100.0 10969000.0 False True 9525081.724783866 8228721.495513389 8378348.113646215 1.0 0.8639003562670332 0.8796090527859831 23.183300040243477 -10.238659014342332 6.752556685853382 1.0000009269221155 0.8717547045265082 0.9888724562676472 0.006413048499276981 8.949078755250744e-08 1.0092088998191496e-08 0.006209452430069424 0.0020698025030100133 5.7721948853410673e-11 10.238659014342332 -0.12824622239560735 VNIISVTNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNIISVTNK 9 0 Q9BY44;Q9BY44-3;Q9BY44-4;C9IZE1;H7C5Q3 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 7660300.0 3316700.0 2866000.0 1477600.0 False True 2757983.0047230846 2850560.2891435423 1786559.328349511 1.0 1.0335670249823576 0.6477774972833419 21.39518213601027 -6.885710107101078 1.0473959744623575 1.022910307857881 0.6172524964252458 0.9780086310981865 0.02587597882717114 0.12269413777108217 0.24271724040504827 0.018921529273802425 0.04650028042589498 1.3010377349315193e-07 6.885710107101078 -0.40565781143263513 VNIISVTNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNIISVTNK 9 0 Q9BY44;Q9BY44-3;Q9BY44-4;C9IZE1;H7C5Q3 Q9BY44 EIF2A Eukaryotic translation initiation factor 2A;Eukaryotic translation initiation factor 2A, N-terminally processed 0 11864800.0 4697800.0 4248800.0 2918200.0 False True 6081394.70748224 4012350.5450046337 2387117.543260565 1.0 0.6597747289890658 0.3925279739405134 22.535970798719777 -7.597389270189066 0.19741184924387717 1.2126509110706756 7.308593485354229e-12 0.9999366182741164 0.001979123910087953 0.13264827739226823 0.021409999220705814 0.03997534712085577 0.07442781987983198 2.527031932222956e-08 7.597389270189066 -1.212650911063367 down VNILEVASGAVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNILEVASGAVLR 13 0 Q12788 Q12788 TBL3 Transducin beta-like protein 3 0 2701890.0 472490.0 1164300.0 1065100.0 False True 619438.9655996681 990590.9784058547 954893.6691606364 1.0 1.5991744682171887 1.5415460153305345 19.240602612549907 -10.200601864499856 5.207327567294602 0.9999607878401655 1.570360241774093 0.9924015648347697 0.02352671737386262 1.0710969650113833e-05 1.6442737186112523e-06 0.022781207294501435 0.007593215381541799 6.30083541505144e-11 10.200601864499856 0.5703994539339274 VNILEVASGAVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNILEVASGAVLR 13 0 Q12788 Q12788 TBL3 Transducin beta-like protein 3 0 2756810.0 701010.0 1199800.0 856000.0 False True 678756.8212634742 1678886.3968743426 631787.9205504513 1.0 2.4734725961931017 0.9308015783538021 19.372535265996223 -6.656577351357873 1.9849748676366865 1.951119964884569 0.9372629543891904 0.22115876951114466 0.6278889757967435 0.4926295802750421 3.7276026632560075 0.255881222172876 0.6958381764975142 2.2050713603813831e-07 6.656577351357873 -1.0138570104953786 VNILEVASGAVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNILEVASGAVLR 13 0 Q12788 Q12788 TBL3 Transducin beta-like protein 3 0 5176890.0 472490.0 2497000.0 2207400.0 False True 647182.3215621412 2386674.283525215 1686057.582830035 1.0 3.6877927656682 2.605228119891008 19.303812674072798 -10.429116865443188 6.328522583901003 0.9994765367517718 3.1465104427796042 0.8397949534799056 0.4419551659551563 0.003264743699023408 0.00029450433224073466 0.4280005031390033 0.14264041645955453 3.7229151187331074e-11 10.429116865443188 2.1470339060278323 VNILFDFVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNILFDFVK 9 0 P55010 P55010 EIF5 Eukaryotic translation initiation factor 5 0 11300200.0 1999600.0 6083400.0 3217200.0 False True 2621494.9641539454 5175780.432907479 2884315.0055615366 1.0 1.97436214972013 1.1002557872516887 21.32195834378912 -10.306475033619622 4.026671382564143 0.9991366289013599 1.537308968511869 0.33501805145584707 0.3568524282784507 48045084.875209495 61490455.52131995 300808.19660064165 0.12216007732579812 4.9377030291350124e-11 10.306475033619622 0.5381723396105091 VNILFDFVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNILFDFVK 9 0 P55010 P55010 EIF5 Eukaryotic translation initiation factor 5 0 9726200.0 4801700.0 2969100.0 1955400.0 False True 4649272.661817697 4154677.113651952 1443222.0792574186 1.0 0.8936187261660029 0.31041889435952574 22.148573606133354 -6.937774113943487 0.6799545809610485 1.0068665893069684 0.16293811192706323 0.9978575978926163 0.014030454763842126 0.08879690948716237 0.05934466010899323 0.013437403470379935 0.05070674482601977 1.1540533501294418e-07 6.937774113943487 -0.8439284773799052 down VNILFDFVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNILFDFVK 9 0 P55010 P55010 EIF5 Eukaryotic translation initiation factor 5 0 25179200.0 5873100.0 11658000.0 7648100.0 False True 8909922.081123313 9577538.815630248 6136449.682718687 1.0 1.0749295816987399 0.6887209143747122 23.086981384498024 -6.85639698683578 1.2038446083924887 1.040324712835169 0.6712693849054603 0.9491015102328171 0.03772625311369722 0.15056280355587562 0.4166999121641599 0.02447566494607568 0.05691995265068538 1.3918839057896115e-07 6.85639698683578 -0.36905532792970863 VNILFDFVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNILFDFVK 9 0 P55010 P55010 EIF5 Eukaryotic translation initiation factor 5 0 13081600.0 1999600.0 4659000.0 6423000.0 False True 2738906.15715816 4453149.974747287 4906019.685837317 1.0 1.6258862915434078 1.7912332165946552 21.38516840531201 -11.243572477333133 0.24483426753367682 6.747669236728152e-19 1.8733175248933638 0.9992750118194408 0.009175460690439634 3.439956166579384 0.1343607256197581 1.9538846371793193 0.07801341646548277 5.707258225155131e-12 11.243572477333133 1.8733175248933638 VNILFDFVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNILFDFVK 9 0 P55010 P55010 EIF5 Eukaryotic translation initiation factor 5 0 10824100.0 4801700.0 2710100.0 3312300.0 False True 3992826.3013775293 2695500.153387271 4004886.615655178 1.0 0.6750857537823072 1.0030204956006947 21.92897888156763 -10.948816789208328 10.352481545342433 1.0475126552908165 0.8390531246926375 0.24309259566555774 0.133878797731065 0.08353976867322685 0.0004130245709694665 0.07376041477770864 0.043209196168557146 1.1250794981483412e-11 10.948816789208328 -0.208459530598179 VNILFDFVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNILFDFVK 9 0 P55010 P55010 EIF5 Eukaryotic translation initiation factor 5 0 21371000.0 5873100.0 9464900.0 6033000.0 False True 7602843.72610881 8938169.994684232 4935055.90380748 1.0 1.1756351066364548 0.6491065819043577 22.858107706590474 -6.816778987699392 1.3857656698523901 1.0949882964454056 0.6383894150271837 0.8767938528881791 0.07683116440778177 0.19771332673641556 0.7469011405086922 0.04357777725685832 0.10053558627337444 1.5248285410600745e-07 6.816778987699392 -0.4565988814182219 VNILSDMHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNILSDMHLR 10 0 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85;C9JZE0;C9JY20 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 0 18093300.0 4641900.0 4359800.0 9091600.0 False True 6085575.85222355 3709334.8343672943 8150888.444785314 1.0 0.6095289787591713 1.3393783337376592 22.536962354833335 -6.76140107093537 1.6074030711323994 0.7735823054309622 1.342210217407872 0.6965583037419796 0.16426674864836496 0.2805828981532333 1.4291574116954344 0.08062287170492745 0.19346634346937028 1.7322035689484492e-07 6.76140107093537 0.5686279119769099 VNILSDMHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNILSDMHLR 10 0 B4DXZ6;P51114;P51114-2;E9PFF5;P51114-3;E7EU85;C9JZE0;C9JY20 B4DXZ6 FXR1 Fragile X mental retardation syndrome-related protein 1 0 14506400.0 4641900.0 2616400.0 7248100.0 False True 6358135.872630763 2500798.7967222165 5536248.059305235 1.0 0.3933226415445378 0.870734468436979 22.600172416356227 -9.993354318049457 6.939307842381231 1.0000000380530827 0.6320285549907853 0.44199577210400887 0.19490256217607105 1.1480803058462427e-07 1.661464590530638e-08 0.18871361404456055 0.06290453145342291 1.0154199270762518e-10 9.993354318049457 -0.36797148306229743 VNINGGAVSLGHPIGMSGAR ddPTM_RPMI8226_Bortezomib_1h_R1 2 VNINGGAVSLGHPIGMSGAR 20 0 P24752;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 280129300.0 73832500.0 62223000.0 144073800.0 False True 96795122.49494712 52939570.94335436 129166425.22947654 1.0 0.5469239521456043 1.3344311355793703 26.528431016157278 -6.750681545038081 1.6471799340029771 0.7338030320285279 1.3360900723812021 0.6519257438638155 0.19039327682630122 0.2988738358359622 1.5956378548396866 0.09129818043744153 0.22150132094019176 1.7754909172800791e-07 6.750681545038081 0.6022870403526742 VNINGGAVSLGHPIGMSGAR ddPTM_RPMI8226_Bortezomib_2h_R1 2 VNINGGAVSLGHPIGMSGAR 20 0 P24752;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 158176900.0 50498700.0 17061200.0 90617000.0 False True 48895646.410090856 23873826.13298263 66881689.2482713 1.0 0.4882607734183807 1.3678454864330942 25.54320267985562 -6.748971423675 1.6535229693971287 0.6987243195341701 1.3694716417382442 0.6445955811560955 0.21502651287585856 0.30183769283218276 1.6233694798725964 0.10273865339679074 0.24970418862615124 1.7824960507956778e-07 6.748971423675 0.6707473222040741 VNINGGAVSLGHPIGMSGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VNINGGAVSLGHPIGMSGAR 20 0 P24752;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 201804500.0 73832500.0 69785800.0 58186200.0 False True 101130370.49828961 66702432.60521981 44443817.94240509 1.0 0.6595687554249386 0.43947053415726145 26.59164107768017 -8.515374018278964 0.14141788667187774 1.4449527867177525 3.318152380661635e-11 0.9999194730171327 0.002069199319491623 0.15939633037110773 0.035125083181408244 0.1748549730171589 0.15110789553513376 3.0522913204853264e-09 8.515374018278964 -1.444952786684571 VNINGGAVSLGHPIGMSGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNINGGAVSLGHPIGMSGAR 20 0 P24752;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 92411000.0 41008000.0 26320000.0 25083000.0 False True 34099968.96242783 26178208.93588906 30327739.329311583 1.0 0.767690110355609 0.8893773294259422 25.023267090329846 -10.211298587906999 5.093526890386482 1.0000164780860137 0.8285337198906658 0.7258259988503022 0.04967859915714694 9.296890481777314e-06 1.4395629570077107e-06 0.04810571775181503 0.016033698933157214 6.14754069166967e-11 10.211298587906999 -0.17148275819534786 VNINGGAVSLGHPIGMSGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNINGGAVSLGHPIGMSGAR 20 0 P24752;A0A5F9ZHD4;A0A5F9ZI66;A0A5F9ZHJ0 P24752;A0A5F9ZHJ0 ACAT1 Acetyl-CoA acetyltransferase, mitochondrial 0 55733000.0 13421000.0 26746000.0 15566000.0 False True 17373749.067461185 25257561.58837643 12733147.720647631 1.0 1.4537772757222918 0.7328957999338894 24.050405769866988 -6.7365705027942 1.6994100943725545 1.271064449023076 0.7327940703842858 0.5893898703979101 0.19067917906769988 0.32405236001966947 1.8362222735624605 0.08881640150857006 0.21876006797498362 1.8341273931229192e-07 6.7365705027942 -0.5382703786387902 VNINVPMK(ub)TEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNINVPMKTEQK 12 1 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 1 12255100.0 2920600.0 6342100.0 2992400.0 True False 3828934.883130636 5395883.401312169 2682775.153127672 1.0 1.4092387481137718 0.70065833841869 21.8685116944944 -6.750081451308581 1.6493634018104972 1.240607587186007 0.6992246220687052 0.6494186587994658 0.17196580039264056 0.2998909483856001 1.6051266809281615 0.08235882233058588 0.19994196853385474 1.7779459275534458e-07 6.750081451308581 -0.5413829651173018 VNINVPMK(ub)TEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNINVPMKTEQK 12 1 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 1 16006700.0 5372900.0 3947800.0 6686000.0 True False 5202340.2304767715 5524177.127505028 4934736.02429943 1.0 1.0618638694837461 0.9485608025769554 22.310729323232263 -6.758459192825151 1.6184466838744664 1.0360028352040356 0.9481805265408051 0.6845900473501512 0.02601450726301648 0.28550724944838635 1.4736117962750352 0.012684968169233852 0.03052838772967271 1.743977217341625e-07 6.758459192825151 -0.08782230866323049 VNINVPMK(ub)TEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNINVPMKTEQK 12 1 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 1 31238100.0 11359000.0 8811100.0 11068000.0 True False 17232433.454134908 7238690.363561482 8880404.948723271 1.0 0.4200619943101863 0.5153308714267761 24.038623108335013 -10.825862890693662 7.378642309426118 1.0276225605273568 0.46769643286848694 0.9765396496157966 0.03889335621725964 0.015235466360730796 0.000359558944648574 0.03246378377364572 0.012552776742296597 1.4932657679006857e-11 10.825862890693662 -0.5599261276588698 VNINVPMK(ub)TEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNINVPMKTEQK 12 1 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 1 11129900.0 2920600.0 3543200.0 4666100.0 True False 4000424.7462473135 3386649.708204459 3564063.2813460296 1.0 0.8465725324245582 0.8909212164756699 21.931721756017293 -10.230620399730396 5.714911427406198 1.0000052622731157 0.8687468744501113 0.9211278988000687 0.018105274448197903 1.2139686355423139e-06 1.6342264513172083e-07 0.017531059494764828 0.005843452201364034 5.88003079084157e-11 10.230620399730396 -0.13125838782300436 VNINVPMK(ub)TEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNINVPMKTEQK 12 1 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 1 14802100.0 5372900.0 4708100.0 4721100.0 True False 4467804.409828048 4682736.530815319 5708260.182099938 1.0 1.0481068778468623 1.2776432579598156 22.09113459866654 -6.9408545809556665 0.6515655371659755 0.9974566841461645 1.3411295422518001 0.9982736957911414 0.005033466277137256 0.08737892394503993 0.052850574333696346 0.004932027736498056 0.019682535772351246 1.1458965689056387e-07 6.9408545809556665 0.34367285810563564 VNINVPMK(ub)TEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNINVPMKTEQK 12 1 A0A590UJC4;A0A590UK34;A0A590UJ50;Q13616;A0A0C4DGX4;A0A590UJR3;A0A590UJ21 A0A590UJC4 CUL1 Cullin-1 1 24609300.0 11359000.0 6613400.0 6636900.0 True False 14704449.419364557 6245358.476354172 5429052.300344752 1.0 0.42472576145078555 0.3692115322043364 23.809749430427463 -13.999999999999998 0.33065358237577325 7.286959645965821 0.3594550694876733 0.9997161970077272 0.004804162038936685 18.87852946491326 0.18391245071960344 82.56747454016826 0.017746293122700357 1.0000000000000041e-14 13.999999999999998 -6.927504576478148 VNIVFNYDMPEDSDTYLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNIVFNYDMPEDSDTYLHR 19 0 O00148 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 34979400.0 9709400.0 6021000.0 19249000.0 False True 9401180.41165685 8425216.699100213 14207109.442378052 1.0 0.8961871095095139 1.5112048509102287 23.164410482191727 -6.863467322097829 1.1680070198356507 0.9430624120065503 1.5430331739572318 0.9577221774011495 0.055272622360779934 0.14327738694305525 0.3694585740922715 0.03685182091104106 0.08639246509390637 1.3694074237282393e-07 6.863467322097829 0.5999707619506816 VNIVFNYDMPEDSDTYLHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNIVFNYDMPEDSDTYLHR 19 0 O00148 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 122280000.0 28374000.0 57467000.0 36439000.0 False True 43045432.41725712 47211564.858279675 29236815.678218924 1.0 1.0967845415197253 0.6792083163392207 25.359356824514844 -6.845679135542018 1.255691563129832 1.0515169478279398 0.663849899251713 0.9337881630520802 0.04592173980122251 0.1622747892459916 0.49454654768367323 0.028645143542485943 0.06613168664406985 1.4266612469319473e-07 6.845679135542018 -0.3876670485762268 VNIVFNYDMPEDSDTYLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNIVFNYDMPEDSDTYLHR 19 0 O00148 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 25067500.0 9709400.0 10735000.0 4623100.0 False True 8073796.299351259 10677168.424269341 5589768.835200746 1.0 1.322447090364079 0.6923346376288799 22.944815757626003 -6.767582226733267 1.583535573522873 1.1855148082941647 0.6890946494804919 0.7213050996220003 0.13581469972930352 0.2703490524108495 1.337500350738921 0.06761627870864352 0.16132578751164708 1.70772435907941e-07 6.767582226733267 -0.49642015881367274 VNIVFNYDMPEDSDTYLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNIVFNYDMPEDSDTYLHR 19 0 O00148 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 83221000.0 28374000.0 32199000.0 22648000.0 False True 36730702.33515712 30407097.34480424 18526296.388104044 1.0 0.8278387128933229 0.504381762675184 25.130483146607293 -6.961248780358935 0.4174613795381233 1.0146941735704995 0.3053753386271306 0.9998137461199992 0.002803921846739384 0.07925801192321835 0.01950507289890084 0.0041779137194400484 0.02694464789380965 1.0933298860072846e-07 6.961248780358935 -0.7093188349433689 VNK(ub)IEIHYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNKIEIHYAK 10 1 E9PHA2;Q15003;Q15003-2;H7C415 E9PHA2 NCAPH Condensin complex subunit 2 1 13902600.0 5137200.0 3612700.0 5152700.0 True False 6650206.669351146 3411650.0691814665 4214961.471166722 1.0 0.5130141420874575 0.6338090950755326 22.664967745459048 -10.059056308276805 7.418634115444072 1.0000000446161457 0.5734116185815227 0.9432744305769057 0.049314333054044444 3.639210191020349e-08 4.5556322242378335e-09 0.04774840228667478 0.015916132553969998 8.728581909727387e-11 10.059056308276805 -0.426588426034623 VNLAELFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNLAELFK 8 0 P30044-2;P30044;P30044-3 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 102458000.0 18164000.0 28912000.0 55382000.0 False True 23813179.900426228 24598442.29809334 49651601.90165646 1.0 1.0329759570519625 2.0850471087554228 24.505256948417294 -6.9135828833617845 0.8709991526985605 0.9709991133645 2.2319586680402375 0.9922043239376325 0.04449121196139794 0.10209619488040064 0.12627562505429188 0.03708341464722723 0.1050930371789336 1.2201609356966745e-07 6.9135828833617845 1.2609595546757375 up VNLAELFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNLAELFK 8 0 P30044-2;P30044;P30044-3 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 78434000.0 31344000.0 19001000.0 28089000.0 False True 30349001.876838144 26588198.388906006 20731648.248062607 1.0 0.8760814769726473 0.6831080749276521 24.855145733871577 -6.964627759136636 0.3643950311576704 1.0158155609765198 0.5367157084331685 0.9999052498908093 0.0012692031835301752 0.07808762671887971 0.015307468933897821 0.0025673253662423577 0.016440051502898984 1.0848563636734023e-07 6.964627759136636 -0.4790998525433513 VNLAELFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNLAELFK 8 0 P30044-2;P30044;P30044-3 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 51558100.0 8001600.0 37743000.0 5813500.0 False True 12139012.195317013 31007466.762595028 4664459.176852433 1.0 2.554364907431025 0.38425360332465003 23.533147692156096 -6.714427050037698 1.7793202399122634 1.951222720413989 0.3886308244041681 0.4861665629708001 0.6545653837164864 0.36623595641788337 2.262831462250465 0.2924505787219952 0.7390297043588672 1.9300695094851332e-07 6.714427050037698 -1.5625918960098208 VNLAELFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNLAELFK 8 0 P30044-2;P30044;P30044-3 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 111971000.0 18164000.0 39016000.0 54791000.0 False True 24879721.663643148 37292144.11134153 41850494.256066166 1.0 1.498897158718488 1.6821126386322274 24.568467009940186 -11.394339139998184 0.18205579250332218 5.482721298131111e-19 1.849171066699182 0.9994595921659452 0.006700633324775887 3.9094024860217806 0.10909742439168578 1.6953257592205138 0.13179391006750196 4.033303098432706e-12 11.394339139998184 1.849171066699182 VNLAELFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNLAELFK 8 0 P30044-2;P30044;P30044-3 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 54879000.0 31344000.0 12246000.0 11289000.0 False True 26063924.77463755 12180028.367359312 13649477.70556148 1.0 0.4673136710098063 0.5236923381103218 24.635551009305853 -10.648542458671278 7.7314868887489725 1.0009673178710572 0.495503004560064 0.9907204935624708 0.02301649446241668 0.00038439375724082486 1.7473747781489345e-05 0.022321726422190397 0.007428541645084587 2.2462471615689136e-11 10.648542458671278 -0.5054643133109932 VNLAELFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNLAELFK 8 0 P30044-2;P30044;P30044-3 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 0 17344400.0 8001600.0 5856000.0 3486800.0 False True 10358228.935116427 5530108.45216228 2852238.177589244 1.0 0.5338855210483066 0.2753596387428354 23.304274014248545 -9.066126827482591 0.19638766315783032 1.416410922757422 2.7144843727156883e-09 0.999595891506269 0.006027760763737296 0.5199115166866397 0.06615286338848948 0.27763524721183924 0.14150485970392415 8.587626994925744e-10 9.066126827482591 -1.4164109200429376 down VNLAELFK(ub)GK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNLAELFKGK 10 1 P30044-2;P30044;P30044-3 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 1 7484400.0 3228600.0 1878400.0 2377400.0 True False 3126109.8602462895 2628454.915726595 1754687.619528786 1.0 0.8408069560036233 0.561300689346389 21.57593704889256 -6.962509589550141 0.3984901428109956 1.0156230364781933 0.37630361469342394 0.9998522504424039 0.0022040929430042606 0.07881653665660956 0.017906046740422645 0.0035972727186859596 0.02343137044617575 1.0901604205539881e-07 6.962509589550141 -0.6393194217847693 VNLAELFK(ub)GK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNLAELFKGK 10 1 P30044-2;P30044;P30044-3 P30044-2 PRDX5 Peroxiredoxin-5, mitochondrial 1 6379400.0 3228600.0 2110100.0 1040700.0 True False 2684723.951231332 2098732.472477944 1258305.558346871 1.0 0.7817311986639719 0.4686908528415955 21.356342324326835 -6.965991982124502 0.3405974952552938 1.0337195655713975 0.2062898538255428 0.9999321575166761 0.0017960199969074859 0.07762592691778948 0.013681828725964757 0.0044109709111621355 0.027083165540486936 1.0814539167434632e-07 6.965991982124502 -0.8274297117458548 down VNLEVIKPWITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNLEVIKPWITK 12 1 E9PCT1;A9Z1X7;Q8IYB3-2;Q8IYB3;M0R088;M0R1E7;M0QXG5 E9PCT1 SRRM1 Serine/arginine repetitive matrix protein 1 0 39956100.0 9653100.0 16844000.0 13459000.0 False True 12655307.580753364 14330940.857397748 12066391.787844324 1.0 1.1324055749694102 0.9534649166643185 23.593239236048518 -6.708469637532174 1.8003881835051005 1.081524439630953 0.9538986167964882 0.4579870133795205 0.055808222822945036 0.37814316132261083 2.388296396862174 0.02467535594656645 0.06280998882163726 1.9567275622148506e-07 6.708469637532174 -0.12762582283446466 VNLEVIKPWITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNLEVIKPWITK 12 1 E9PCT1;A9Z1X7;Q8IYB3-2;Q8IYB3;M0R088;M0R1E7;M0QXG5 E9PCT1 SRRM1 Serine/arginine repetitive matrix protein 1 0 36183900.0 10994000.0 5314900.0 19875000.0 False True 10645001.487811347 7437167.286837348 14669141.262780609 1.0 0.6986534755634363 1.3780309264941812 23.343672815641753 -6.786123150240124 1.5116872808794504 0.8307209984253332 1.3845133776992582 0.7885288439446329 0.12781485131803477 0.24119211784896047 1.0888706609271133 0.06656567090664861 0.1563046159071547 1.6363524451405247e-07 6.786123150240124 0.553792379273925 VNLEVIKPWITK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNLEVIKPWITK 12 1 E9PCT1;A9Z1X7;Q8IYB3-2;Q8IYB3;M0R088;M0R1E7;M0QXG5 E9PCT1 SRRM1 Serine/arginine repetitive matrix protein 1 0 27053900.0 2682600.0 20993000.0 3378300.0 False True 4069700.324329808 17246635.130942352 2710577.524238507 1.0 4.2378145210931475 0.6660386043743604 21.95649113371232 -6.667975057493398 1.944384480844126 3.070167785751236 0.6804773738275562 0.27032481694692734 1.3759756450799772 0.4656820641816409 3.3921960061109457 0.5700883970268925 1.5272591539598261 2.147953832396483e-07 6.667975057493398 -2.38969041192368 VNLEVIKPWITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNLEVIKPWITK 12 1 E9PCT1;A9Z1X7;Q8IYB3-2;Q8IYB3;M0R088;M0R1E7;M0QXG5 E9PCT1 SRRM1 Serine/arginine repetitive matrix protein 1 0 38152100.0 9653100.0 10374000.0 18125000.0 False True 13222111.935218748 9915642.377769552 13844248.296092398 1.0 0.7499287879539123 1.047052722282324 23.65644929757141 -6.683572589749058 1.8894750956958888 0.842282024702315 1.0459466660559111 0.3403790782937852 0.10590522078751242 0.43066082808529726 2.975688215383898 0.044927787991869625 0.11794227558018024 2.0721796780819406e-07 6.683572589749058 0.2036646413535962 VNLEVIKPWITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNLEVIKPWITK 12 1 E9PCT1;A9Z1X7;Q8IYB3-2;Q8IYB3;M0R088;M0R1E7;M0QXG5 E9PCT1 SRRM1 Serine/arginine repetitive matrix protein 1 0 24426100.0 10994000.0 7318800.0 6113300.0 False True 9141998.11678042 7279372.17173195 7391562.765294449 1.0 0.7962561443072753 0.8085281435058499 23.12407809107603 -10.45754888830552 8.922340194857727 1.0000028567408727 0.8023921439073464 0.9971157715960897 0.005010022693391969 2.847074329347067e-07 1.730940440628213e-08 0.004851003750155564 0.0016169778713023555 3.486993290224263e-11 10.45754888830552 -0.19761071283352638 VNLEVIKPWITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNLEVIKPWITK 12 1 E9PCT1;A9Z1X7;Q8IYB3-2;Q8IYB3;M0R088;M0R1E7;M0QXG5 E9PCT1 SRRM1 Serine/arginine repetitive matrix protein 1 0 12098600.0 2682600.0 6208800.0 3207200.0 False True 3472678.5819515227 5863274.822026161 2623522.5086509767 1.0 1.6884012394637475 0.7554751891770674 21.72761745580477 -6.708990921241858 1.7986010398312489 1.423640981464895 0.7577111257526693 0.4604153242083304 0.29013374066477465 0.37709921143231667 2.377318712645745 0.12839474203889217 0.32660726878332585 1.9543803109127316e-07 6.708990921241858 -0.6659298557122256 VNLEVIKPWITK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNLEVIKPWITKR 13 2 E9PCT1;A9Z1X7;Q8IYB3-2;Q8IYB3;M0R088;M0R1E7;M0QXG5 E9PCT1 SRRM1 Serine/arginine repetitive matrix protein 1 1 5864600.0 1959000.0 2823100.0 1082500.0 True False 1628995.2984148469 2807891.399958521 1308845.7450855067 1.0 1.7236952142776851 0.803468092485673 20.635551009305853 -6.696993851776089 1.841475482834207 1.4507058580028807 0.8063483947391554 0.40333089287994883 0.30565279616997265 0.4018347161049635 2.6469753732039805 0.13252080722850618 0.3420934377092944 2.009121255152717e-07 6.696993851776089 -0.6443574632637252 VNLFTDFDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNLFTDFDK 9 0 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 9621600.0 1807300.0 3865900.0 3948400.0 False True 2369387.801918098 3289122.789160177 3539857.443727213 1.0 1.3881741040860949 1.4939966521569754 21.17608291569297 -12.189508211959875 0.21132575143400528 7.92189224302155e-10 1.561257103331284 0.9993956606666743 0.00522076222055797 5.728822441146166 0.13216445919193448 2.5364578398030684 0.061862717112008345 6.463857715458163e-13 12.189508211959875 1.5612571025390949 VNLFTDFDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNLFTDFDK 9 0 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 8235300.0 2562900.0 1529400.0 4143000.0 False True 2481542.142360533 2140097.39571564 3057824.012664157 1.0 0.8624062268311516 1.2322273156140897 21.24280552448643 -6.805988801009516 1.4316246273096642 0.9246494796024413 1.238102068082694 0.8490095092604782 0.059303379211276847 0.21232903739691927 0.8584607116224211 0.03258091412050107 0.07550222977327402 1.5631879514682888e-07 6.805988801009516 0.3134525884802527 VNLFTDFDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNLFTDFDK 9 0 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 5260400.0 1807300.0 3453100.0 0.0 False True 2475507.6504460615 3300530.6241253167 0.0 1.0 1.3332742573146943 0.0 21.23929297721586 -6.873926540877251 1.3529666880569846 1.174515591966164 3.2254624576717785e-20 0.924274759698874 0.15590128420346827 0.15366700838481806 0.5655446331712319 0.09330175468850353 0.1914776628562381 1.3368216152939064e-07 6.873926540877251 -1.174515591966164 down VNLGVGAYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNLGVGAYR 9 0 P17174 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 22701000.0 6411800.0 4958200.0 11331000.0 False True 8405931.89195953 4218455.886912221 10158576.814626943 1.0 0.5018427392859646 1.2085009663644621 23.00297633660037 -6.717278394269484 1.7689099173934268 0.6960458225910733 1.2072466141242226 0.4996596686148509 0.20970052226051789 0.3606703667171877 2.2040112272932086 0.09417896696128539 0.2372023548613245 1.9174392172932375e-07 6.717278394269484 0.5112007915331493 VNLGVGAYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNLGVGAYR 9 0 P17174 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 13074600.0 4477300.0 1305300.0 7292000.0 False True 4335170.562250118 1826513.097049578 5382006.444689125 1.0 0.4213243910065556 1.2414751316948553 22.04765732504849 -6.7171589373625595 1.7699419340790008 0.6468710716984806 1.2399634676373328 0.49892569156406275 0.24359722927273084 0.3608505847048686 2.207745555257288 0.10935656959308838 0.27540560084203486 1.9179667000772605e-07 6.7171589373625595 0.5930923959388522 VNLGVGAYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNLGVGAYR 9 0 P17174 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 15989600.0 6411800.0 3966500.0 5611300.0 False True 8782415.732379826 3791246.9145385507 4286026.50835108 1.0 0.4316861134870477 0.4880236416671736 23.06618639812326 -10.39699821544568 5.190019366615602 1.0004007924379432 0.4598548775770877 0.9919070487105702 0.022999699568576143 0.00010673930793280993 1.240154067301026e-05 0.022285369817931548 0.007423121116394251 4.008683648273754e-11 10.39699821544568 -0.5405459148608556 VNLGVGAYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNLGVGAYR 9 0 P17174 P17174 GOT1 Aspartate aminotransferase, cytoplasmic 0 9627900.0 4477300.0 2613800.0 2536800.0 False True 3723073.328020831 2599718.9406013223 3067233.1511620465 1.0 0.6982722905388815 0.8238444104974354 21.828062600482767 -10.075138388933444 4.988723128338899 1.000005813174402 0.7610583507302922 0.8284043162194142 0.051264603307337245 71193509.3334332 11.986443495172338 4753.993544352139 0.017549237269954936 8.411270718649463e-11 10.075138388933444 -0.23894746244410991 VNLLYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNLLYSR 7 0 Q13011;M0R248 Q13011 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 6190060.0 939660.0 2046900.0 3203500.0 False True 1231903.3596803853 1741510.4987537088 2872032.550141861 1.0 1.4136746077269728 2.3313781292771245 20.23245765329658 -6.957968718177673 0.4631805035740078 0.9740834483412838 2.8081612424470355 0.9996872636654484 0.009838946266315596 0.08043497248975848 0.023874603683239827 0.012532204457634727 0.07578658285631147 1.1016186552375433e-07 6.957968718177673 1.8340777941057516 up VNLLYSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNLLYSR 7 0 Q13011;M0R248 Q13011 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 6460260.0 939660.0 1907800.0 3612800.0 False True 1287077.6953566908 1823507.0877490595 2759531.0479515945 1.0 1.4167808939022184 2.1440283348138043 20.295667714819473 -6.962622715821666 0.3967435139717854 0.9585577199575424 2.628666922193425 0.999855445677588 0.005683853189445645 0.07877719754943228 0.01776458032354296 0.00936347331735742 0.06100708982969779 1.0898764894239671e-07 6.962622715821666 1.6701092022358828 up VNLQMVYDSPLCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNLQMVYDSPLCR 13 0 K7ER00;Q9Y285;Q9Y285-2 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 40277000.0 12756000.0 15271000.0 12250000.0 False True 16723239.529279705 12992626.325891769 10982487.510297416 1.0 0.7769204228130422 0.6567200984635091 23.99535100924522 -13.999999999976048 0.07604730694976061 2.233911674551634 0.26997017576395355 0.9999024722201963 0.001404555834585512 12.298226882580284 0.07642261666221778 2.6022020994280246 0.3530565728936564 1.0000000000551524e-14 13.999999999976048 -1.9639414987876807 VNLQMVYDSPLCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNLQMVYDSPLCR 13 0 K7ER00;Q9Y285;Q9Y285-2 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 20795000.0 10754000.0 3386400.0 6654600.0 False True 10412620.156441985 4738607.179842703 4911560.626279243 1.0 0.45508307310250484 0.4716930563572516 23.31182980787946 -9.808833880878735 6.595180583551924 1.0000000074766127 0.4633880647586386 0.9992819290701032 0.006780997268641387 7.380973998985785e-10 1.483449080700408e-10 0.006565672470753434 0.002188557457639126 1.552980916865047e-10 9.808833880878735 -0.5366119427179741 VNLQMVYDSPLCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNLQMVYDSPLCR 13 0 K7ER00;Q9Y285;Q9Y285-2 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 48796100.0 9963100.0 27337000.0 11496000.0 False True 15114751.100175338 22458498.765044134 9223810.561124202 1.0 1.485866265094078 0.610252229758332 23.849453886015443 -6.756054733160089 1.6270290542537638 1.2835892021685102 0.6076282203043177 0.6748040017555725 0.20425850518808356 0.28957939869836924 1.5098487932714115 0.09909215306418126 0.23909863727405728 1.7536594781412675e-07 6.756054733160089 -0.6759609818641925 VNLQMVYDSPLCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNLQMVYDSPLCR 13 0 K7ER00;Q9Y285;Q9Y285-2 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 41925000.0 12756000.0 10096000.0 19073000.0 False True 17472237.917938314 9649925.336992621 14568350.220765261 1.0 0.5523004770376485 0.8337998995428225 24.05856107076811 -10.322460960487192 6.414062651239276 1.0000138448904357 0.6930501882902359 0.6132015187555744 0.11492165800430215 2.275332390016795e-05 2.4035679971050994e-06 0.11127742973224496 0.03709080563076719 4.7592557087234917e-11 10.322460960487192 -0.30696365660019975 VNLQMVYDSPLCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNLQMVYDSPLCR 13 0 K7ER00;Q9Y285;Q9Y285-2 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 17602000.0 10754000.0 1740500.0 5107500.0 False True 8942427.482977679 1731123.5810378 6175454.635588204 1.0 0.1935854201035539 0.6905792244156819 23.092235083313735 -10.413196382970762 9.782220484286158 1.0000010146766523 0.44208232228905936 0.626902160037565 0.2028968709815579 4.489838632804365e-06 2.6933186689804305e-07 0.19645440761663804 0.06548468352576411 3.861923058450138e-11 10.413196382970762 -0.557918692387593 VNLQMVYDSPLCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNLQMVYDSPLCR 13 0 K7ER00;Q9Y285;Q9Y285-2 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 0 38755100.0 9963100.0 17054000.0 11738000.0 False True 12897429.352061901 16104929.908329174 9601804.442050759 1.0 1.2486930122826758 0.7444742808779741 23.620580208107892 -6.772605190057091 1.564625533719048 1.1421687396510158 0.7413643703740594 0.7403791308342439 0.10488815370050625 0.2622354199505492 1.2673117285551874 0.05283072838697302 0.12545353101866416 1.6880869400202186e-07 6.772605190057091 -0.4008043692769564 VNLSAAQTLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNLSAAQTLR 10 0 Q9BUL8;C9J5C3;C9J6F3;C9JND6;H7C5M9;C9JSA3;C9J932;F8WDF3 Q9BUL8 PDCD10 Programmed cell death protein 10 0 20264200.0 4026100.0 6870800.0 9367300.0 False True 5278256.088807856 5845703.422168637 8398061.653486453 1.0 1.1075065938092716 1.5910674874782809 22.33162991792135 -6.942190815183749 0.6388627451737926 0.9947102747293449 1.730323616108201 0.9984369421211164 0.01016326564972175 0.08678134330776512 0.05016497919385244 0.010065822398172341 0.04123415792074753 1.1423763006927036e-07 6.942190815183749 0.735613341378856 VNLSAAQTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNLSAAQTLR 10 0 Q9BUL8;C9J5C3;C9J6F3;C9JND6;H7C5M9;C9JSA3;C9J932;F8WDF3 Q9BUL8 PDCD10 Programmed cell death protein 10 0 9221000.0 2639600.0 1072200.0 5509200.0 False True 2555807.342843993 1500335.0514491335 4066175.2475426933 1.0 0.587029791447279 1.5909553037820243 21.285347659130565 -6.794976250973433 1.476146110441391 0.7706803319840955 1.6031878756683973 0.817142665757375 0.17617541596449424 0.2279942693904073 0.9812138415874926 0.09391201689677711 0.2191249519792745 1.6033330652059421e-07 6.794976250973433 0.8325075436843018 VNLSAAQTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNLSAAQTLR 10 0 Q9BUL8;C9J5C3;C9J6F3;C9JND6;H7C5M9;C9JSA3;C9J932;F8WDF3 Q9BUL8 PDCD10 Programmed cell death protein 10 0 11990100.0 4026100.0 3361200.0 4602800.0 False True 5514657.97126148 3212691.0699979775 3515713.437641607 1.0 0.5825730420164341 0.6375215754019622 22.394839979444242 -10.169307639539163 5.2872315376317465 1.0000158106263706 0.6100473087093564 0.9853266296520239 0.02243264481867825 4.180982126171284e-06 6.568902608300238e-07 0.02172119482061362 0.0072401049827660185 6.771616592337747e-11 10.169307639539163 -0.38996850191701415 VNLSAAQTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNLSAAQTLR 10 0 Q9BUL8;C9J5C3;C9J6F3;C9JND6;H7C5M9;C9JSA3;C9J932;F8WDF3 Q9BUL8 PDCD10 Programmed cell death protein 10 0 6186300.0 2639600.0 1925200.0 1621500.0 False True 2194944.3541071154 1914828.565477719 1960548.1530310877 1.0 0.8723813712610746 0.8932108685865168 21.06575293456484 -10.333102542405108 8.188129136984296 1.0000004057882723 0.8827961199302118 0.9768597899551257 0.008503606674333364 6.299520719290274e-08 5.124521868648288e-09 0.008233610344459345 0.002744527252699279 4.644056102543026e-11 10.333102542405108 -0.11720428585806053 VNLTLGSIWDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNLTLGSIWDK 11 0 Q14697-2;E9PKU7;E9PNH1 Q14697-2 GANAB Neutral alpha-glucosidase AB 0 12400100.0 5917000.0 2835400.0 3647700.0 False True 5729168.073802047 3967590.006415667 2692257.941345655 1.0 0.6925246310294848 0.46992127070885387 22.449894231354005 -7.713379825318938 0.14959339108654077 1.3221771627905219 4.34124823640295e-12 0.9999730148200081 0.0011289362961419522 0.1340052606481808 0.01834605262249268 0.05972186722059536 0.08827173756530048 1.9347291481575974e-08 7.713379825318938 -1.3221771627861807 down VNLTLGSIWDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNLTLGSIWDK 11 0 Q14697-2;E9PKU7;E9PNH1 Q14697-2 GANAB Neutral alpha-glucosidase AB 0 15431500.0 3525100.0 4277100.0 7629300.0 False True 4828424.732245562 4088123.5795217073 5827416.470365663 1.0 0.84667853517941 1.2068980658326425 22.203121157627738 -6.7910721876710864 1.492165106260073 0.9144266887097139 1.2108362277626077 0.8047285135587348 0.06522384285738743 0.23376648990093454 1.0282466787521212 0.034404185626040605 0.08048203814521673 1.6178111055535362e-07 6.7910721876710864 0.2964095390528938 VNLTLGSIWDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNLTLGSIWDK 11 0 Q14697-2;E9PKU7;E9PNH1 Q14697-2 GANAB Neutral alpha-glucosidase AB 0 10043500.0 5917000.0 2007500.0 2119000.0 False True 4920247.667545 1996685.1990424474 2562073.1028509815 1.0 0.4058098969718552 0.5207203531137183 22.23029950678828 -10.010663987638722 6.122668924311467 1.0000004703086407 0.4632651250433268 0.9667660377248051 0.0469119972764455 3.0114646278735053e-07 4.864098247869897e-08 0.045422385979068794 0.01514078201573437 9.757442762210556e-11 10.010663987638722 -0.5367353452653139 VNLVSGHVK(ub)TQLIAHDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNLVSGHVKTQLIAHDK 17 1 P61962;A0A087WWI6 P61962 DCAF7 DDB1- and CUL4-associated factor 7 1 16759100.0 5819200.0 6794100.0 4145800.0 True False 7970715.497966972 6493914.196915756 3166647.425431168 1.0 0.8147216142104317 0.39728521564204117 22.926277804084105 -6.957649987805192 0.4673765322095757 1.011311442032259 0.18365791666379006 0.9996728676484006 0.004559107338601438 0.08055150965629256 0.024315770596388574 0.005743693418341454 0.034460227798673235 1.1024274341062172e-07 6.957649987805192 -0.827653525368469 down VNNSSLIGLGYTQTLK(ub)PGIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNNSSLIGLGYTQTLKPGIK 20 1 P21796 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 1 4655300.0 2129800.0 0.0 2525500.0 True False 2062190.66479358 0.0 1863995.7866240242 1.0 0.0 0.9038910991339423 20.97574629603388 -9.147256585655303 10.518112853058346 1.0000055891831603 0.45194554956790195 0.328939287785621 0.36901199600123513 0.0 0.0 0.3572943287594237 0.11909810958647453 7.124319935989944e-10 9.147256585655303 -0.5480600396152584 VNNSSLIGLGYTQTLK(ub)PGIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNNSSLIGLGYTQTLKPGIK 20 1 P21796 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 1 6718600.0 2129800.0 2453700.0 2135100.0 True False 1771023.066137798 2440481.431078686 2581539.5384129984 1.0 1.3780065758267201 1.4576543850683743 20.756151571468155 -12.236311272818142 0.24906435461423365 5.567899243446307e-13 1.4925944522920618 0.9994039090106496 0.004874033052536036 5.851398965683368 0.14752528351057978 3.011307649843471 0.036898928108148675 5.803483141263246e-13 12.236311272818142 1.492594452291505 VNNSSLIGLGYTQTLK(ub)PGIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNNSSLIGLGYTQTLKPGIK 20 1 P21796 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 1 17339300.0 3605400.0 3399900.0 10334000.0 True False 4667261.373058986 3210692.5762477024 8453318.03579422 1.0 0.6879178858036338 1.8111944800412587 22.154144831795993 -6.832572933518878 1.316286499720417 0.8335146684708792 1.8430596611688024 0.9109369936918403 0.14128627214407655 0.17765877448995912 0.6010737084327348 0.084251255531569 0.19389411888194247 1.4703714669058625e-07 6.832572933518878 1.0095449926979232 VNNSSLIGLGYTQTLKPGIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNNSSLIGLGYTQTLKPGIK 20 1 P21796 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 0 46145000.0 14992000.0 16453000.0 14700000.0 False True 19654657.182734516 13998276.533291703 13178985.012356918 1.0 0.7122116861742256 0.6705273406617287 24.228367864652146 -13.999999999999998 0.2721199685976465 3.2467564193136313 0.6569725966337063 0.9995879027623586 0.0029735985241414013 14.987853640496084 0.16515113725056796 18.65251914424292 0.017130716728461583 1.0000000000000041e-14 13.999999999999998 -2.589783822679925 VNNSSLIGLGYTQTLKPGIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNNSSLIGLGYTQTLKPGIK 20 1 P21796 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 0 20574800.0 8547700.0 3107400.0 8919700.0 False True 8276357.942274432 4348201.024876924 6583362.984735807 1.0 0.5253761443384349 0.7954420326734478 22.980564610652742 -10.176294495308282 5.530810063847251 1.0000094448999908 0.660409088505906 0.678270169911138 0.11025393722550093 1.2840866317956175e-05 1.912456618430264e-06 0.10675588248760466 0.03558430522732844 6.663547604764734e-11 10.176294495308282 -0.3396003563940848 VNNSSLIGLGYTQTLKPGIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNNSSLIGLGYTQTLKPGIK 20 1 P21796 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 0 38677000.0 14992000.0 10467000.0 13218000.0 False True 20534947.54356627 10004533.330259677 10096180.633255145 1.0 0.4871954656341044 0.4916584574582145 24.291577926175037 -9.976060895877973 5.231201883418466 1.0000022471171148 0.4894269615434143 0.9999426970251021 0.001822008792136978 4.775370638924519e-08 9.346984279253474e-09 0.0017641602029041 0.0005880508076677805 1.0566693348272635e-10 9.976060895877973 -0.5105752855737005 VNNSSLIGLGYTQTLKPGIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNNSSLIGLGYTQTLKPGIK 20 1 P21796 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 0 14357100.0 8547700.0 3415900.0 2393500.0 False True 7107791.277315267 3397497.8686969387 2893969.783706383 1.0 0.47799629113198033 0.4071545816127966 22.760969886087018 -13.999999999999998 0.2814401029771864 5.288220900185183 0.3861291132764037 0.9996083689117359 0.00523157860218535 15.476665230159584 0.1680760826134865 38.23249473226751 0.02783280225684478 1.0000000000000041e-14 13.999999999999998 -4.9020917869087794 VNNSSLIGVGYTQTLRPGVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNNSSLIGVGYTQTLRPGVK 20 1 A0A0A0MR02;P45880-2;P45880;P45880-1 A0A0A0MR02 VDAC2 Voltage-dependent anion-selective channel protein 2 0 33374900.0 13232000.0 7959900.0 12183000.0 False True 17347280.138870265 6772313.947447178 10922420.027588049 1.0 0.3903962980497658 0.6296329995336876 24.048206146164233 -10.266285811824112 5.611157121560917 1.0000374280761335 0.5100146487917325 0.8483253122579562 0.09766797439706303 4.573369485740669e-05 5.98016114181011e-06 0.09457380929786303 0.031522203191464204 5.416443136844455e-11 10.266285811824112 -0.49002277928440097 VNNSSLIGVGYTQTLRPGVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNNSSLIGVGYTQTLRPGVK 20 1 A0A0A0MR02;P45880-2;P45880;P45880-1 A0A0A0MR02 VDAC2 Voltage-dependent anion-selective channel protein 2 0 25065500.0 13232000.0 6294000.0 5539500.0 False True 18124227.981354643 6015910.268525304 4231184.18958366 1.0 0.3319264287954329 0.23345458873815228 24.111416207687125 -13.999999999999998 0.2696238114564646 6.14603532460105 0.20064887405255397 0.9995825201083551 0.006957699587484051 14.864594690524514 0.1643712869758144 41.91953123344407 0.040974427959553285 1.0000000000000041e-14 13.999999999999998 -5.945386450548496 VNNSTMLGASGDYADFQYLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNNSTMLGASGDYADFQYLK 20 0 P28070 P28070 PSMB4 Proteasome subunit beta type-4 0 14485500.0 4312000.0 1678600.0 8494900.0 False True 4175117.9202694674 2348873.7337833615 6269830.848462651 1.0 0.5625885971699123 1.5017134768873757 21.993385514356497 -6.780041414564263 1.5355700795293388 0.752339965186058 1.5091803100187169 0.7675765009314035 0.18498086865779076 0.2505135313518351 1.1667377560449326 0.09487696209559315 0.22387506969386717 1.659428655849113e-07 6.780041414564263 0.7568403448326589 VNNSTMLGASGDYADFQYLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNNSTMLGASGDYADFQYLK 20 0 P28070 P28070 PSMB4 Proteasome subunit beta type-4 0 7978400.0 4312000.0 1915000.0 1751400.0 False True 3585619.0539891915 1904683.5149022627 2117609.6424413486 1.0 0.5312007455959944 0.5905841112946439 21.773790789790773 -10.236926509542132 5.475911920610041 1.000029110368499 0.5608924284457292 0.9864689200322924 0.024243157528565065 8.61634137257069e-06 1.2007105732437286e-06 0.023474889352530105 0.007824445447286648 5.7952675450738184e-11 10.236926509542132 -0.4391366819227699 VNNVFDHFSDCEFLAALYNPFGNFKPHLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNNVFDHFSDCEFLAALYNPFGNFKPHLQK 30 1 D6RCM8;O95379-3;O95379-2;O95379;O95379-4 D6RCM8 TNFAIP8 Tumor necrosis factor alpha-induced protein 8 0 180618000.0 78904000.0 73777000.0 27937000.0 False True 119703136.6550805 60610917.92766804 22415239.70477793 1.0 0.5063436065365257 0.18725691181649226 26.834885715703123 -8.349751496787635 0.2895836649842692 1.1697804309555617 7.407588489625263e-24 0.9990119540186814 0.010509453257964953 0.11599213812979751 0.07199433300354548 0.10072992066370572 0.09856177969911062 4.4693925754850786e-09 8.349751496787635 -1.1697804309555617 down VNPCIGGVILFHETLYQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNPCIGGVILFHETLYQK 18 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 66072000.0 27550000.0 27225000.0 11297000.0 False True 36118316.794579536 23163136.122218795 10128094.80847592 1.0 0.6413127237893602 0.28041436332924286 25.106227325338843 -7.444679298483754 0.30494397664694084 1.081626191195666 2.8877157670127696e-14 0.9997342922734751 0.004788608370836521 0.11990650497225108 0.028979514633677896 0.019646385355147046 0.06094361448584297 3.591870757504015e-08 7.444679298483754 -1.081626191195637 down VNPCIGGVILFHETLYQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNPCIGGVILFHETLYQK 18 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 141603000.0 68431000.0 40598000.0 32574000.0 False True 66258695.362235576 56808993.11577313 24041892.200946722 1.0 0.8573817037175117 0.36284886186650606 25.981606461156527 -6.948157900429067 0.5787141279808374 1.005940264724372 0.1898838981010545 0.9990486801831495 0.00842091435423659 0.08423398407241689 0.039089493742670144 0.00883523944362379 0.041296775674530654 1.1267877051482784e-07 6.948157900429067 -0.8160563666233176 down VNPCIGGVILFHETLYQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNPCIGGVILFHETLYQK 18 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 779932500.0 155192500.0 429490000.0 195250000.0 False True 235438368.5914982 352844153.87931406 156658751.91888472 1.0 1.4986688702873363 0.6653917662447724 27.81077420974711 -6.744628741547994 1.669766723438304 1.2951038556835277 0.6643943074737907 0.6255341036894881 0.20951148088307434 0.30950268903488354 1.6960337049352834 0.0991942558911399 0.24218649432749745 1.8004093449177737e-07 6.744628741547994 -0.630709548209737 VNPCIGGVILFHETLYQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNPCIGGVILFHETLYQK 18 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 92918000.0 27550000.0 16361000.0 49007000.0 False True 37735979.51075582 15638116.921408113 37432555.93084691 1.0 0.41440866579204094 0.9919593029293852 25.169437386861734 -10.86396591597935 10.889139663833536 1.0097992570160326 0.7031839843646103 0.26043955241169325 0.23578406026763565 0.05464796448999994 0.000682695987851962 0.22241840343163372 0.07609897822647654 1.367836171023517e-11 10.86396591597935 -0.3066152726514223 VNPCIGGVILFHETLYQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNPCIGGVILFHETLYQK 18 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 156098000.0 68431000.0 18389000.0 69278000.0 False True 56903408.50731314 18289934.807069264 83763709.49471949 1.0 0.32142072481859624 1.4720332523482194 25.762011736590804 -6.746957834435452 1.661723098485687 0.5995204376031509 1.473713835676278 0.6355221130242759 0.2851077726131805 0.30538154173846266 1.6582402254321822 0.13560952645108357 0.3302018675373808 1.7907797120399779e-07 6.746957834435452 0.8741933980731271 VNPCIGGVILFHETLYQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNPCIGGVILFHETLYQK 18 0 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 468302500.0 155192500.0 185960000.0 127150000.0 False True 200899750.55152133 175611162.52802217 104010004.66917317 1.0 0.8741233478186234 0.5177209249072686 27.58190053183956 -6.952743849124268 0.5278650171742455 1.0057085605192464 0.37001551464183685 0.9993993741301072 0.005005675941481031 0.08240235695598674 0.03154502642873973 0.005602330454719301 0.029464632003457954 1.1149519486014496e-07 6.952743849124268 -0.6356930458774095 VNPCIGGVILFHETLYQK(ub)ADDGRPFPQVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNPCIGGVILFHETLYQKADDGRPFPQVIK 30 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 15218200.0 9322200.0 2198300.0 3697700.0 True False 9026271.863714296 3076092.6539830556 2729161.4413778065 1.0 0.34079326442060526 0.30235754944952 23.10569880128979 -13.727386526873468 0.4067772009279781 9.99999999929516 0.30042019327928515 0.9998425554217434 0.0040177308549220955 22.037410034030234 0.2106471244137912 174.0162235292247 0.009658099970758557 1.8733264846883283e-14 13.727386526873468 -9.699579806015874 VNPCIGGVILFHETLYQK(ub)ADDGRPFPQVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNPCIGGVILFHETLYQKADDGRPFPQVIK 30 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 141623700.0 36156700.0 57772000.0 47695000.0 True False 54852357.308840536 47462135.22530378 38268062.34453891 1.0 0.8652706566114037 0.697655747574795 25.70905028674877 -6.968179554536873 0.29849103637083024 1.0295962925165116 0.5280893385798403 0.9999644906080605 0.0007369517033609625 0.07689801281418097 0.01113363830558212 0.0028018092892450426 0.015056835760596752 1.0760202522711762e-07 6.968179554536873 -0.5015069539366713 VNPCIGGVILFHETLYQK(ub)ADDGRPFPQVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNPCIGGVILFHETLYQKADDGRPFPQVIK 30 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 17882500.0 9322200.0 3816400.0 4743900.0 True False 7751822.343482852 3795840.2957039094 5735827.556684655 1.0 0.48967070290190096 0.7399327929008728 22.886104076724067 -10.13860338502464 5.167182200955273 1.0000136361208063 0.6148017479009869 0.7595439568517697 0.10216907041139348 1.605018325166632e-05 2.6758310788688857e-06 0.09892827690383488 0.032974925683200366 7.267693691244669e-11 10.13860338502464 -0.38521188821981944 VNPCIGGVILFHETLYQK(ub)ADDGRPFPQVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNPCIGGVILFHETLYQKADDGRPFPQVIK 30 2 P04075;J3KPS3;P04075-2;H3BQN4;H3BPS8;H3BUH7;H3BR04;H3BMQ8;H3BU78 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 1 119245300.0 36156700.0 52587600.0 30501000.0 True False 46805560.905109465 49661053.83178442 24950130.966688566 1.0 1.0610075570393012 0.5330591169983163 25.48017660884122 -6.878124305064456 1.0901567757003567 1.0369544018454602 0.4969566046736968 0.9721429324006184 0.03935882166258191 0.12930692332709007 0.2824085499771401 0.02785593694328061 0.06705601537318068 1.323962532445036e-07 6.878124305064456 -0.5399977971717633 VNPLGGAVALGHPLGCTGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNPLGGAVALGHPLGCTGAR 20 0 H0Y4D4;H7C131;C9JDE9;P09110-2;P09110 H0Y4D4 ACAA1 3-ketoacyl-CoA thiolase, peroxisomal 0 7849300.0 1592700.0 2542500.0 3714100.0 False True 2088045.1237287417 2163168.910587379 3329800.5601629107 1.0 1.035978047602958 1.5946976060635583 20.993721458950485 -6.92000499326108 0.8246713063162773 0.9876754660545977 1.6848123235464765 0.9941829283886158 0.02076515896641055 0.09816810473758106 0.10559207261113719 0.017891985028152556 0.05359906126215841 1.2022506117715124e-07 6.92000499326108 0.6971368574918788 VNPLGGAVALGHPLGCTGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNPLGGAVALGHPLGCTGAR 20 0 H0Y4D4;H7C131;C9JDE9;P09110-2;P09110 H0Y4D4 ACAA1 3-ketoacyl-CoA thiolase, peroxisomal 0 6316300.0 1592700.0 2032200.0 2691400.0 False True 2181564.2310991217 1942410.6844132734 2055746.7511229287 1.0 0.89037519809107 0.9423269422084339 21.056931520473377 -10.147090565812045 4.528820528166151 1.0000114758922716 0.9163510701478572 0.7756177409539 0.021209210728981295 2.4578548462865526e-06 4.629045707161281e-07 0.020538547146527007 0.006845243327388549 7.127043904703361e-11 10.147090565812045 -0.08366040574441436 VNPLSLVEIILHVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNPLSLVEIILHVVR 15 0 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;E9PQG3 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 0 1747332000.0 428679000.0 791893000.0 526760000.0 False True 650337383.632811 650573507.0617504 422645655.1128899 1.0 1.000363078357299 0.6498867599337042 29.27661311634086 -6.906662637602808 0.9181706849785904 1.0120296806954399 0.6076849384400729 0.9895998116859209 0.016840235441601587 0.10666625752416373 0.15104792058356756 0.013563746676348524 0.03663000042371619 1.2397592645475785e-07 6.906662637602808 -0.404344742255367 VNPLSLVEIILHVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNPLSLVEIILHVVR 15 0 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;E9PQG3 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 0 788701000.0 428679000.0 160733000.0 199289000.0 False True 554933416.0263914 151788067.25433752 163020446.87782001 1.0 0.27352482815184953 0.29376577832549755 29.04773943843331 -10.515247113691986 9.616419303187614 1.0000156149680473 0.28364530332208915 0.999401578659363 0.008263333305756036 2.7664433542799798e-06 1.3945748651503306e-07 0.00800111165454677 0.002666979356446185 3.053183356614004e-11 10.515247113691986 -0.7163703116459581 VNPQISDEK(ub)DEDEKEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNPQISDEKDEDEKEEK 17 2 P26358;P26358-2 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 6622400.0 3518200.0 1540700.0 1563500.0 True False 4818973.61578008 1472626.7795864241 1194233.5012932678 1.0 0.3055893011665805 0.24781905785552827 22.20029447156675 -13.999999999999998 0.35228504071157013 9.661041912034158 0.2400773666068543 0.9997590386639084 0.00530541778838486 20.889592822705207 0.19123116243417076 135.53904635993328 0.01710336032248503 1.0000000000000041e-14 13.999999999999998 -9.420964545427303 VNPQISDEKDEDEKEEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNPQISDEKDEDEKEEKR 18 3 P26358;P26358-2 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 10705500.0 3879600.0 3645600.0 3180300.0 True False 5885636.836751632 2995014.196797195 2551712.3110249923 1.0 0.50886833147697 0.43354905880216 22.488767095295763 -13.999999999999998 0.2639651205952566 4.670879926480638 0.40704822789140194 0.9995705260177801 0.0052050567704028244 14.596109254515325 0.1625998316906128 28.64911494551849 0.03225498875214563 1.0000000000000041e-14 13.999999999999998 -4.263831698589236 VNPQISDEKDEDEKEEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNPQISDEKDEDEKEEKR 18 3 P26358;P26358-2 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 11069600.0 3609400.0 3932200.0 3528000.0 True False 4943892.720367409 3758462.401953485 2694759.061440773 1.0 0.7602232925624995 0.5450682718779767 22.237216007252314 -6.972409674942183 0.19209814464923564 1.1418820507833698 0.15751890366495455 0.9999955841016714 0.0003904312510712106 0.07552828305547155 0.006143553755554737 0.007461664615967941 0.023319608783150824 1.065590463332933e-07 6.972409674942183 -0.9843631471184152 VNPQISDEKDEDEKEEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNPQISDEKDEDEKEEKR 18 3 P26358;P26358-2 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 14704900.0 6157300.0 5500000.0 3047600.0 True False 5120067.7646399895 5470370.408335472 3684839.069489693 1.0 1.0684175795708661 0.7196856055183065 22.28773147389771 -6.855777827872928 1.2068722821351563 1.0367797768578433 0.7041096999756946 0.9482984533335589 0.03430606232701207 0.15121666808143774 0.4209490655742438 0.022205280517938783 0.051612050064550025 1.3938696828169626e-07 6.855777827872928 -0.33267007688214867 VNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIK ddPTM_RPMI8226_Bortezomib_8h_R1 3 VNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIK 43 1 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 851925600.0 181013000.0 262876000.0 408036600.0 False True 274609954.82289976 215963723.94043761 327387987.1612051 1.0 0.7864380738845247 1.1921927133790278 28.032808684341067 -6.763748467592821 1.5988856864077285 0.8765272607844073 1.1939283542933248 0.7058775190923077 0.08987784458698259 0.2766686280457419 1.3948583717403922 0.044340069566620455 0.10614315134016263 1.7228661266744188e-07 6.763748467592821 0.31740109350891743 VNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIK 43 1 P07954-2;P07954 P07954-2 FH Fumarate hydratase, mitochondrial 0 479020500.0 162525000.0 76252000.0 240243500.0 False True 210391816.346705 72008509.16910502 196521648.10647637 1.0 0.3422590784160639 0.9340745829325797 27.648503348017886 -10.60563535369083 9.342787241594818 1.000074824425349 0.6381668306743367 0.3326239049670532 0.2416076679888762 0.00037663554389593263 1.5898147203584397e-05 0.2339833887298164 0.07797853953641075 2.479503046931259e-11 10.60563535369083 -0.36190799375101235 VNPTVFFDIAVDGEPLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNPTVFFDIAVDGEPLGR 18 0 P62937;F8WE65;C9J5S7;E5RIZ5 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 894891100.0 175520000.0 420321100.0 299050000.0 False True 266276672.23080885 345311515.7212568 239942636.42172876 1.0 1.2968147484656127 0.9011027305228836 27.98835080262644 -6.705968615369542 1.8094457090677458 1.1832215043014633 0.9021337066216482 0.4459779537356232 0.125157987657406 0.383247392317492 2.443361554230488 0.05509596868867414 0.14066496823697566 1.9680285056875444e-07 6.705968615369542 -0.2810877976798152 VNPTVFFDIAVDGEPLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNPTVFFDIAVDGEPLGR 18 0 P62937;F8WE65;C9J5S7;E5RIZ5 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 461740000.0 175520000.0 110030000.0 176190000.0 False True 227214100.0164509 103906733.77585652 144125227.86206543 1.0 0.4573075956480403 0.6343146303492185 27.759477124718888 -10.433823620408685 7.003351292882832 1.000049215785817 0.5458111129986304 0.8977370195143098 0.07226281931683369 5.553595903340376e-05 4.489701888811468e-06 0.06997571138811415 0.023322724647007718 3.6827851186482335e-11 10.433823620408685 -0.45423810278718657 VNQIGSVTESLQACK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNQIGSVTESLQACK 15 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 260558000.0 29627000.0 132860000.0 98071000.0 False True 38841283.908276126 113037805.88422376 87923553.68345946 1.0 2.910248954467187 2.2636623931147937 25.21108755439935 -10.16458559997065 5.334651095243352 0.9999445475865958 2.5869556737915147 0.8892805743094627 0.26396785831085945 0.00017409818106421177 2.726300469611417e-05 0.25559458961759135 0.08519525993073447 6.845645412891956e-11 10.16458559997065 1.587011126204919 VNQIGSVTESLQACK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNQIGSVTESLQACK 15 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 113183000.0 54479000.0 18925000.0 39779000.0 False True 52749593.96529694 26481851.192571223 29359686.555579916 1.0 0.5020294793168111 0.556586019882829 25.65265665307388 -10.391220334749061 5.400090910269072 1.0002428127632612 0.5293077495998133 0.9900246793404563 0.022272614419722673 6.514266289391244e-05 7.343836823585713e-06 0.021576291926154702 0.007188455393670362 4.0623717670536306e-11 10.391220334749061 -0.4709350631634479 VNQIGSVTESLQACK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNQIGSVTESLQACK 15 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 615740000.0 10587000.0 587230000.0 17923000.0 False True 16061253.013374973 482434218.4510681 14380511.194070052 1.0 30.037147042595123 0.895354253002223 23.937081112836765 -3.0748066402795176 19.396843578485733 9.999999999999998 13.273791466076407 0.0 13.728095713838139 0.0 0.0 4.370517507221218 0.0 0.0008417698370626988 3.0748066402795176 3.2737914660764087 VNQIGSVTESLQACK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNQIGSVTESLQACK 15 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 314697000.0 29627000.0 154620000.0 130450000.0 False True 40580902.53957031 147788377.14003554 99640396.70208283 1.0 3.6418208539331416 2.455351913499799 25.27429761592224 -9.096847379919328 10.58955137662483 1.000000000000174 3.048586383715887 0.7989940206988014 0.48437391662241186 0.0 0.0 0.4689930281030503 0.1563310093676834 8.001153827330812e-10 9.096847379919328 2.0485863837157128 VNQIGSVTESLQACK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNQIGSVTESLQACK 15 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 82268000.0 54479000.0 10619000.0 17170000.0 False True 45301702.32891402 10561793.339293538 20760167.614889786 1.0 0.23314340954804308 0.4582646246748108 25.433061928508156 -10.09544143432093 5.209715035349427 1.000012684749465 0.3457040171139743 0.9184539391402896 0.09190535122588682 1.354085780832897e-05 2.3514046352387994e-06 0.08898869670878803 0.029662324559967673 8.027098009652361e-11 10.09544143432093 -0.6543086676354908 VNQIGSVTESLQACK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNQIGSVTESLQACK 15 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 80480000.0 10587000.0 43367000.0 26526000.0 False True 13705080.200969504 40953588.327343166 21698540.179744273 1.0 2.988204937643932 1.5832479534274675 23.708207434929214 -6.555837764897049 2.364145835829832 2.3729748020192356 1.5852463190259687 0.0 0.868987866762212 0.7747555652750518 8.111139744033343 0.3136588062059985 0.9787243823870402 2.780751851782599e-07 6.555837764897049 -0.7877284829932669 VNQIGSVTESLQACK(ub)LAQANGWGVMVSHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNQIGSVTESLQACKLAQANGWGVMVSHR 29 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 9494300.0 3048600.0 2153800.0 4291900.0 True False 2951823.861719273 3013823.571918621 3167722.635759908 1.0 1.0210038651029931 1.0731408051952278 21.4931752062355 -6.9556145145984924 0.4933777908556191 0.9988931819408478 1.0974750172009424 0.999571339827447 0.0006365854788209904 0.08130661969670068 0.027215923710535345 0.0007561880688198795 0.004300178098617663 1.1076064736265219e-07 6.9556145145984924 0.09858183526009467 VNQIGSVTESLQACK(ub)LAQANGWGVMVSHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNQIGSVTESLQACKLAQANGWGVMVSHR 29 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 154470900.0 6647900.0 14494000.0 133329000.0 True False 10085350.326590668 11907432.457861133 106976464.70982328 1.0 1.1806662210301637 10.607114403133128 23.265757862754068 -6.911049638819156 0.8885592455844621 0.7177386027613931 11.853065179982964 0.9913116222242124 0.41822680614106106 0.10372792630941798 0.13503356072018097 0.3441949665579606 0.9571841716461691 1.2272989458112675e-07 6.911049638819156 11.135326577221571 up VNQIGSVTESLQACK(ub)LAQANGWGVMVSHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNQIGSVTESLQACKLAQANGWGVMVSHR 29 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 12115500.0 3048600.0 1544900.0 7522000.0 True False 2535045.97587928 1536577.3170613577 9094815.422201555 1.0 0.6061339051369261 3.5876333244989853 21.273580481669775 -6.873636707488886 1.1147360916814906 0.7715299970840137 3.7747051048906677 0.9681771033046693 0.23591487027428867 0.13341282500765306 0.3076565153087973 0.1638600305947331 0.3905717591352484 1.3377140624021476e-07 6.873636707488886 3.003175107806654 up VNQIGSVTESLQACK(ub)LAQANGWGVMVSHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNQIGSVTESLQACKLAQANGWGVMVSHR 29 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 100600200.0 6647900.0 13825000.0 80127300.0 True False 8605837.599700114 13055626.596848287 65544953.57552684 1.0 1.5170663454424511 7.616336331725674 23.036884184846517 -6.923643272116987 0.7972464931964683 0.8822623439376361 8.687308574526952 0.9951344725722863 0.2095754051432458 0.09607511804203007 0.09485347525959736 0.1841469152295192 0.572372967289432 1.1922208917826538e-07 6.923643272116987 7.805046230589316 up VNQK(ub)AAESLADPTEYENLFPGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNQKAAESLADPTEYENLFPGLK 23 1 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 1 17042800.0 7007500.0 4121900.0 5913400.0 True False 6785050.74821157 5767796.165424536 4364503.141802607 1.0 0.8500741379045447 0.6432528368270525 22.693928175523848 -6.966612003176231 0.32922178141142644 1.0254271647235225 0.4611371705349217 0.9999426140582675 0.0011079369802864942 0.0774181915613869 0.01295415846675619 0.0030262723881774047 0.018050761142530868 1.0799110793068291e-07 6.966612003176231 -0.5642899941886008 VNQK(ub)AAESLADPTEYENLFPGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNQKAAESLADPTEYENLFPGLK 23 1 P35606-2;P35606 P35606-2 COPB2 Coatomer subunit beta 1 18109500.0 7007500.0 6039100.0 5062900.0 True False 5827046.734886192 6006566.169632509 6121528.981795307 1.0 1.0308079620627624 1.0505371348999257 22.474333450958124 VNQPASFAVSLNGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNQPASFAVSLNGAK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 30355000.0 7743000.0 12004000.0 10608000.0 False True 10151147.983318659 10213049.991225505 9510385.919121217 1.0 1.0060980302925906 0.9368778718180049 23.275139553808085 -6.8854262596485745 1.049037640339301 1.0041371977380729 0.931431118363949 0.977806564901004 0.004661793649447874 0.12293352255915847 0.2441422785588636 0.0034046431214801625 0.008359625988848655 1.301888348907103e-07 6.8854262596485745 -0.07270607937412388 VNQPASFAVSLNGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNQPASFAVSLNGAK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 19726200.0 4951200.0 2766000.0 12009000.0 False True 4794026.866149852 3870478.224499443 8863482.637722388 1.0 0.8073543041296881 1.848859609091171 22.192806563324268 -6.858944023828441 1.1911281886948957 0.8957632635256795 1.8982697192012186 0.9523368850637274 0.09877860671064452 0.1478932206657179 0.39932733767054895 0.06470924975681934 0.1508689076505085 1.3837447181943284e-07 6.858944023828441 1.002506455675539 VNQPASFAVSLNGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNQPASFAVSLNGAK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 28548200.0 6341900.0 15738000.0 6468300.0 False True 9621125.95499411 12929430.938444762 5189837.6698433915 1.0 1.3438584006618668 0.5394210297339953 23.1977743109942 -6.79055946100225 1.4941645633263383 1.192041395785218 0.530740839441597 0.8031170122886162 0.14623092936945012 0.2345155454794954 1.0343139179342158 0.0770322859994858 0.18027296790021682 1.6197222160460648e-07 6.79055946100225 -0.6613005563436211 VNQPASFAVSLNGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNQPASFAVSLNGAK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 22624600.0 7743000.0 7503200.0 7378400.0 False True 10605796.346707152 7171683.814235646 5635773.882917965 1.0 0.676204179279973 0.5313862060596457 23.338349615330976 -13.999999999993415 0.10882667572931805 2.565672049073668 0.2611787322629545 0.9997490247258476 0.00310358736796498 12.019687839599444 0.09991113698079788 4.144149695537539 0.24007620884495193 1.0000000000151624e-14 13.999999999993415 -2.3044933168107136 VNQPASFAVSLNGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNQPASFAVSLNGAK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 10828200.0 4951200.0 2951700.0 2925300.0 False True 4117142.1753504784 2935798.6062334226 3536966.704941004 1.0 0.7130670939201919 0.8590829644205605 21.973211838758544 -10.162800092269686 5.050154258059813 1.0000126553082125 0.7860750291700757 0.741063244493493 0.05961072951341242 8.494366405388993e-06 1.4081571181986964e-06 0.05772125356978051 0.019239280221577153 6.873847735493611e-11 10.162800092269686 -0.21393762613813683 VNQPASFAVSLNGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNQPASFAVSLNGAK 15 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 26239000.0 6341900.0 12337000.0 7560100.0 False True 8209714.5675383415 11650435.104905427 6184239.373176678 1.0 1.4191035521468531 0.7532831162765996 22.968900633086648 -6.7365580389208946 1.6992180138994664 1.2503546572474835 0.7531732709575467 0.5894107065298264 0.1761099733661802 0.3240879968702773 1.8359599147653929 0.08203534178631557 0.202079198154042 1.8341800317366853e-07 6.7365580389208946 -0.4971813862899368 VNSININQGSITFAGGPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNSININQGSITFAGGPGR 19 0 F5H6E2;O00159-2;O00159-3;O00159 F5H6E2 MYO1C Unconventional myosin-Ic 0 6984800.0 2092300.0 1774100.0 3118400.0 False True 2025881.0817671188 2482507.3818092793 2301597.4900052864 1.0 1.2253963987085847 1.1360970348751507 20.95011806045233 -10.202117416086734 4.535505617426423 0.9999565220385119 1.1807467167940975 0.8452585257751973 0.036456312632102486 25633319.175231945 0.9656205341767543 11639.00649158433 0.012479965493906408 6.27888579573772e-11 10.202117416086734 0.18079019475558555 VNTDLGNDLYFVK(ub)LPNFLSVEPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNTDLGNDLYFVKLPNFLSVEPR 23 1 Q8WVC0 Q8WVC0 LEO1 RNA polymerase-associated protein LEO1 1 144093000.0 92187000.0 26278000.0 25628000.0 True False 139854418.7724567 21588485.589048903 20562614.566848572 1.0 0.15436398634049164 0.14702870847651922 27.059350596326656 VNTDLGNDLYFVK(ub)LPNFLSVEPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNTDLGNDLYFVKLPNFLSVEPR 23 1 Q8WVC0 Q8WVC0 LEO1 RNA polymerase-associated protein LEO1 1 153670000.0 92187000.0 21176000.0 40307000.0 True False 119337888.77744178 19997536.984799944 32971539.584745225 1.0 0.16757072870707632 0.27628727072786774 26.830476918419105 -10.70756486158779 6.8801190304846145 1.0075688634104636 0.22192899971747204 0.9855688466858328 0.044383342425130826 0.00512913642095718 0.0002180104331206011 0.04277612143758942 0.014324662171796065 1.9608083082092453e-11 10.70756486158779 -0.7856398636929915 VNTFSALLLEPYKPPSAQ ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNTFSALLLEPYKPPSAQ 18 1 O43681 O43681 ASNA1 ATPase ASNA1 0 9245100.0 1804500.0 4372500.0 3068100.0 False True 2365716.9748028563 3720140.0438715066 2750642.4432933475 1.0 1.5725211779323345 1.1627098560775928 21.17384605489019 -10.276626624457963 4.9432330762670675 0.9999023698186813 1.3676155170051782 0.5175836326866172 0.16730477156077084 0.00018006391278176898 2.6349939282809166e-05 0.16203496652756577 0.05399738283287235 5.288997668122913e-11 10.276626624457963 0.36771314718649695 VNTFSALLLEPYKPPSAQ ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNTFSALLLEPYKPPSAQ 18 1 O43681 O43681 ASNA1 ATPase ASNA1 0 11166100.0 1804500.0 4288800.0 5072800.0 False True 2471672.414778904 4099306.634834975 3874709.1175954533 1.0 1.6585153478769823 1.5676467052945013 21.237056116413083 -10.58033142422612 6.109600844801889 0.9983269443348288 1.6130810265857418 0.98379099170294 0.03709696799106964 0.0008472381674109573 5.8196716772067904e-05 0.035996985033728036 0.011972994935350182 2.6282615146543856e-11 10.58033142422612 0.614754082250913 VNTHGIFTISTASMVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNTHGIFTISTASMVEK 17 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 25391100.0 6536000.0 11978000.0 6877100.0 False True 8568759.294714034 10190929.089878308 6165523.661801338 1.0 1.1893120975127602 0.7195351683650137 23.030654895138643 -6.79729327536208 1.4667260365545414 1.1048102219072193 0.7134586715153912 0.824217779527239 0.08091177249833367 0.22462674401168145 0.9542506033172985 0.04340230629161488 0.10111824136740619 1.5948018274438708e-07 6.79729327536208 -0.3913515503918281 VNTHGIFTISTASMVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNTHGIFTISTASMVEK 17 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 28327600.0 11794000.0 4593600.0 11940000.0 False True 11419605.925709203 6427848.4353075335 8812555.807678016 1.0 0.5628783057072382 0.7717040206998843 23.445009530425907 -10.085734205220568 4.952025819592895 1.0000098763484424 0.6672911632017202 0.7719258226893607 0.08525274115701537 9.296111058629656e-06 1.716216887081864e-06 0.08254806085791513 0.027515203892393814 8.208537655275275e-11 10.085734205220568 -0.3327187131467222 VNTHGIFTISTASMVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNTHGIFTISTASMVEK 17 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 31262700.0 6536000.0 9498700.0 15228000.0 False True 8952535.828758616 9079016.025999589 11631460.030504553 1.0 1.0141278627262988 1.299236356378526 23.093864956661534 -6.917203733897706 0.8452139391214563 0.9930531816728692 1.3423791833007432 0.9933680813137954 0.01122620498792666 0.0998450958540189 0.11434878617294104 0.009531939149637509 0.027831813259807655 1.2100303574344228e-07 6.917203733897706 0.3493260016278741 VNTHGIFTISTASMVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNTHGIFTISTASMVEK 17 0 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0 Q92598-2 HSPH1 Heat shock protein 105 kDa 0 21860000.0 11794000.0 4140500.0 5925500.0 False True 9807233.562789544 4118194.3046750934 7164494.653583542 1.0 0.41991396231249994 0.7305316639716789 23.225414805860183 -10.090493247700483 5.33150043298731 1.0000060134754283 0.5752228131417555 0.7137537987164053 0.1268091456914146 9.064224969524714e-06 1.5463591250145497e-06 0.12278416479946726 0.0409274757839574 8.119078721734633e-11 10.090493247700483 -0.4247832003336728 VNTLIRPDGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNTLIRPDGEK 11 1 P62750;H7BY10;K7ERT8;A8MUS3;K7EJV9;K7EMA7 P62750 RPL23A 60S ribosomal protein L23a 0 11457200.0 2707100.0 1133000.0 7617100.0 False True 2621164.592291623 1585412.8085169452 5621953.0018981695 1.0 0.6048505359714386 2.1448302096065732 21.321776517812086 -6.838617825476295 1.288741840626984 0.7897354698274361 2.1941300226320424 0.9220644539542016 0.1823127068970661 0.1704156872288773 0.5503878337467227 0.11095094953516975 0.2555307472604948 1.4500473184781738e-07 6.838617825476295 1.4043945528046062 up VNVDK(ub)VLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNVDKVLER 9 1 K7ENK9;K7EKX0;J3QRU4;F8WCA0;L7N2F9;Q15836;P63027;F5GZV7;P23763-2;P23763-3;P23763 K7ENK9 VAMP2;VAMP3;VAMP1 Vesicle-associated membrane protein 3;Vesicle-associated membrane protein 2;Vesicle-associated membrane protein 1 1 7873700.0 2525300.0 3272200.0 2076200.0 True False 3310692.755039985 2784000.514935702 1861374.7403166923 1.0 0.8409117731319282 0.5622311939043741 21.65870169864934 -6.9625515835661504 0.39784254475623704 1.0156887618328871 0.3773138861409027 0.9998534413792586 0.00219032828382071 0.0788019180946799 0.017853483831903445 0.003587121254998337 0.02336793175565846 1.0900550128115961e-07 6.9625515835661504 -0.6383748756919845 VNVDK(ub)VLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNVDKVLER 9 1 K7ENK9;K7EKX0;J3QRU4;F8WCA0;L7N2F9;Q15836;P63027;F5GZV7;P23763-2;P23763-3;P23763 K7ENK9 VAMP2;VAMP3;VAMP1 Vesicle-associated membrane protein 3;Vesicle-associated membrane protein 2;Vesicle-associated membrane protein 1 1 10785100.0 3603100.0 3250800.0 3931200.0 True False 5466166.121893961 2670669.3413836714 3154196.596893831 1.0 0.4885818106929975 0.5770400179131292 22.38209787470135 -10.820812625904694 7.318883948553787 1.0228055784489605 0.5328109143030637 0.9738164064144491 0.036112911875116914 0.012281072287633109 0.00030067567845174333 0.031954653461329655 0.011655392189615319 1.51073181095909e-11 10.820812625904694 -0.48999466414589676 VNVDK(ub)VLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNVDKVLER 9 1 K7ENK9;K7EKX0;J3QRU4;F8WCA0;L7N2F9;Q15836;P63027;F5GZV7;P23763-2;P23763-3;P23763 K7ENK9 VAMP2;VAMP3;VAMP1 Vesicle-associated membrane protein 3;Vesicle-associated membrane protein 2;Vesicle-associated membrane protein 1 1 6140300.0 2525300.0 2109600.0 1505400.0 True False 3458971.653666481 2016390.8964856989 1149855.5246862057 1.0 0.5829451924962558 0.3324269869246741 21.721911760172233 -8.807053883003938 0.17805335765873384 1.40639780342913 5.2938725580040675e-08 0.9997539909473754 0.004318737453867313 0.32786829595292827 0.05287334045916965 0.2196776568824076 0.14588250131412972 1.5593590208363924e-09 8.807053883003938 -1.4063977504904044 down VNVDK(ub)VLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNVDKVLER 9 1 K7ENK9;K7EKX0;J3QRU4;F8WCA0;L7N2F9;Q15836;P63027;F5GZV7;P23763-2;P23763-3;P23763 K7ENK9 VAMP2;VAMP3;VAMP1 Vesicle-associated membrane protein 3;Vesicle-associated membrane protein 2;Vesicle-associated membrane protein 1 1 9556000.0 3603100.0 3390400.0 2562500.0 True False 4664283.9777192045 3201721.2595988726 2096151.2934703606 1.0 0.6864336037199191 0.44940473253418006 22.1532241967938 -7.562911121841772 0.16555145033640878 1.2695773581232093 2.751105982551846e-11 0.9999729744089104 0.0011722854453675422 0.1334915339758523 0.016553655374865802 0.042254190217882716 0.0729306983411487 2.735828555027104e-08 7.562911121841772 -1.2695773580956982 down VNVEAPDVNLEGLGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNVEAPDVNLEGLGGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 16003400.0 1768800.0 8427400.0 5807200.0 False True 2318913.9290835676 7170064.769747909 5206326.650595847 1.0 3.091992626298774 2.2451573494378816 21.145017841921824 -10.509134535153578 6.114777721804645 0.9983373122100565 2.6685749878682614 0.8380947886635223 0.34571905408295184 0.007839916370547156 0.0006293504706870025 0.3348898970432677 0.11158034491082121 3.096459933484487e-11 10.509134535153578 1.670237675658205 VNVEAPDVNLEGLGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNVEAPDVNLEGLGGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 19604300.0 5850300.0 3290000.0 10464000.0 False True 5664585.428792313 4603714.157123351 7723164.486728866 1.0 0.8127186384591009 1.3634121302987288 22.43353894342622 -6.814922461723903 1.3935759412367155 0.8985089622439948 1.3741860785111837 0.8723338912740242 0.08168700708984054 0.20016072778770638 0.7651210319577747 0.04607667305455791 0.1063758303902409 1.531360844112077e-07 6.814922461723903 0.4756771162671889 VNVEAPDVNLEGLGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNVEAPDVNLEGLGGK 16 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 18780700.0 1768800.0 8134300.0 8877600.0 False True 2422773.1600226825 7774899.72946703 6780893.719911169 1.0 3.2090910770178085 2.798814941406931 21.208227903444715 -9.940650443583811 5.454797955832268 0.9999966630542416 3.0039530092184092 0.9695213255118674 0.16749453100249093 6.796716075080109e-06 1.3202173129564535e-06 0.16217615264422733 0.05405862742638029 1.1464353169412231e-10 9.940650443583811 2.0039563461641676 VNVHVLGVLLGQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNVHVLGVLLGQK 13 0 Q6PGP7 Q6PGP7 TTC37 Tetratricopeptide repeat protein 37 0 13542800.0 5585800.0 3696300.0 4260700.0 False True 7323037.892964146 3144826.44806455 3819843.6355203446 1.0 0.4294428752152228 0.5216200832704125 22.8040108303904 -10.804191963499116 7.254032249165367 1.0199214806993382 0.47553147924281775 0.9773575716582659 0.037631187608263034 0.011330182664330488 0.0003058351804635352 0.034050193977051876 0.012145413575400799 1.56966883805409e-11 10.804191963499116 -0.5443900014565204 VNVHVLGVLLGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNVHVLGVLLGQK 13 0 Q6PGP7 Q6PGP7 TTC37 Tetratricopeptide repeat protein 37 0 23670400.0 5585800.0 7088600.0 10996000.0 False True 7651021.210569137 6775402.213134491 8398971.269728668 1.0 0.88555527774187 1.0977581996670343 22.86722089191329 -6.760228118860542 1.6116813192735289 0.9335431564798935 1.0985404876344766 0.6918834118990389 0.048137150980506034 0.2825283281522129 1.4464551614490262 0.023565595015926713 0.05661750737000952 1.7368882658090268e-07 6.760228118860542 0.16499733115458315 VNVHVLGVLLGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNVHVLGVLLGQK 13 0 Q6PGP7 Q6PGP7 TTC37 Tetratricopeptide repeat protein 37 0 6642800.0 3646300.0 0.0 2996500.0 False True 3032060.0084788436 0.0 3623054.2957493966 1.0 0.0 1.19491510247749 21.53186687595921 -10.75716468082306 6.213785275230227 1.012470536951886 0.597457551238745 0.13142955882383878 0.487822047835887 0.0842064511255129 0.0032907927755943174 0.4719411147332622 0.15744388893176572 1.7491832872306252e-11 10.75716468082306 -0.41501298571314105 VNVNLLIFLLNKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNVNLLIFLLNKK 13 1 P46940;H0YLE8;F2Z2E2;Q86VI3 P46940;F2Z2E2 IQGAP1;IQGAP3 Ras GTPase-activating-like protein IQGAP1;Ras GTPase-activating-like protein IQGAP3 0 76621000.0 17532000.0 34010000.0 25079000.0 False True 26597325.760885056 27940649.778657135 20122124.65748383 1.0 1.0505059805579258 0.7565469114596521 24.66477786086054 -6.862635858799759 1.1724491875618779 1.0276152483522563 0.741585530925705 0.9567586745982603 0.02668698450739756 0.14410519873981673 0.374942970852645 0.017734080494581195 0.04152437389299046 1.3720316860691545e-07 6.862635858799759 -0.28602971742655126 VNVNLLIFLLNKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNVNLLIFLLNKK 13 1 P46940;H0YLE8;F2Z2E2;Q86VI3 P46940;F2Z2E2 IQGAP1;IQGAP3 Ras GTPase-activating-like protein IQGAP1;Ras GTPase-activating-like protein IQGAP3 0 61835000.0 17532000.0 18891000.0 25412000.0 False True 22695519.60738617 17839699.24347641 20787276.749139003 1.0 0.7860449794535899 0.9159198427152936 24.43590418295299 -10.287454647773885 5.233897673108531 1.0000277873473422 0.8509824111292656 0.6370696293180033 0.05302119090088337 1.7195110274053022e-05 2.3409750597981714e-06 0.051347113869670856 0.017112515779591112 5.1587603383176115e-11 10.287454647773885 -0.14904537621807656 VNVNLLIYLLNKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNVNLLIYLLNKK 13 1 Q13576;F5H7S7;Q13576-3;Q13576-2 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 0 127099400.0 30925300.0 47774700.0 48399400.0 False True 46915941.04227119 39248931.519565195 38833237.37578938 1.0 0.8365798627848469 0.8277194598057981 25.483574867443906 VNVNLLIYLLNKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNVNLLIYLLNKK 13 1 Q13576;F5H7S7;Q13576-3;Q13576-2 Q13576 IQGAP2 Ras GTPase-activating-like protein IQGAP2 0 97932900.0 30925300.0 32209500.0 34798100.0 False True 40033410.47879874 30417013.010573957 28465202.858657897 1.0 0.759790700986679 0.711036169994379 25.254701189536355 -13.999999999999998 0.22417482629229493 2.476627253038474 0.6859780871840394 0.9995024144901459 0.002817442433029446 13.116667403944582 0.14996039984033058 8.593326676442675 0.026258192013720826 1.0000000000000041e-14 13.999999999999998 -1.7906491658544343 VNVPVIGGHAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNVPVIGGHAGK 12 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 24763000.0 2715700.0 9919300.0 12128000.0 False True 3560308.9988762112 8439379.105128571 10873110.899990777 1.0 2.3704063629849004 3.0539795572302304 21.763571027313798 -9.181092716207718 0.22675771414622936 1.3136909388751893e-16 3.60506530325392 0.9993276279943929 0.022144798335638347 0.6177815900585025 0.08159198418208737 0.7902412661999864 0.3278339697629026 6.590331852351936e-10 9.181092716207718 3.60506530325392 VNVPVIGGHAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNVPVIGGHAGK 12 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 20061700.0 8126300.0 2055000.0 9880400.0 False True 7868335.054611731 2875572.2166834315 7292426.834353583 1.0 0.3654613328899895 0.9268068509715278 22.90762696203655 -10.479865110341585 8.87594943466199 1.0000085535765078 0.6461340919307701 0.3463425660561389 0.22916834811633952 3.87910242405512e-05 2.273205781482874e-06 0.2218966552619543 0.07396376631103724 3.312339850993046e-11 10.479865110341585 -0.35387446164573766 VNVPVIGGHAGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNVPVIGGHAGK 12 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 48550800.0 1670500.0 44708000.0 2172300.0 False True 2534270.629908652 36729508.094801605 1742943.9528470878 1.0 14.49312779043078 0.6877497344906343 21.273139164670855 -6.651395385410894 2.00349396302691 9.746006095750628 0.7457098137086154 0.19975489176652528 5.757041418594279 0.5051184545138764 3.8879047478553685 2.329120460786699 6.377380851883102 2.2315396849352026e-07 6.651395385410894 -9.000296282042013 VNVPVIGGHAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNVPVIGGHAGK 12 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 23445700.0 2715700.0 10027000.0 10703000.0 False True 3719767.6790330154 9583973.985145096 8175171.835204245 1.0 2.576497999906416 2.1977640919041073 21.82678108883669 -10.084511574447387 5.143294749267949 0.9999735068674892 2.3871310459026502 0.9470498149623282 0.1546174704938408 4.810606003529584e-05 8.56266588042043e-06 0.14971063523719416 0.04990257401966771 8.231678982579109e-11 10.084511574447387 1.3871575390351611 VNVPVIGGHAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNVPVIGGHAGK 12 0 P40926;P40926-2;G3XAL0 P40926 MDH2 Malate dehydrogenase, mitochondrial;Malate dehydrogenase 0 11528700.0 8126300.0 1733300.0 1669100.0 False True 6757378.506129958 1723962.3688668855 2018101.0929535523 1.0 0.2551229544568197 0.29865148017427634 22.688032237470825 -10.655326679163087 7.2444244921246295 1.002302746820308 0.2768872173155488 0.9972896930506688 0.017770446210563968 0.0006620481755952603 3.149870607791705e-05 0.01723547502534867 0.005735386852349075 2.2114306311664015e-11 10.655326679163087 -0.7254155295047593 VNVTGIYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNVTGIYR 8 0 A0A3B3IU45;P33991;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 64020000.0 15584000.0 17932000.0 30504000.0 False True 20430774.915670693 15256615.498388525 27347738.69502959 1.0 0.7467467857367703 1.338556114876166 24.284240589075303 -6.7904708358631005 1.4949198416150375 0.8585420534860755 1.3448904870963283 0.8026958560347381 0.10768939211630028 0.23465682603392957 1.0360487964945042 0.05670539194854249 0.13268900301736086 1.6200527815044552e-07 6.7904708358631005 0.4863484336102528 VNVTGIYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNVTGIYR 8 0 A0A3B3IU45;P33991;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 30803700.0 8142700.0 2544000.0 20117000.0 False True 7884214.445588635 3559832.466784743 14847754.20293622 1.0 0.4515139068517518 1.8832255648809522 22.91053558662132 -6.8028599942628345 1.4441678141504068 0.6984636276602612 1.9044218165044398 0.840401406569591 0.23562185652119164 0.21670208023525664 0.8919486445962638 0.12833398458361092 0.2979582520559712 1.5744903591837135e-07 6.8028599942628345 1.2059581888441786 VNVTGIYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNVTGIYR 8 0 A0A3B3IU45;P33991;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 51163000.0 15584000.0 12154000.0 23425000.0 False True 21345825.94176475 11616996.09209671 17892497.45301871 1.0 0.5442279967891598 0.8382199640263469 24.347450650598194 -10.106240706163527 5.1816254827052335 1.000007219674738 0.6912239804073131 0.5952735154432621 0.12002171803622722 1.0010546960775114e-05 1.726530584911299e-06 0.11621324493626607 0.0387368429279047 7.82995549996603e-11 10.106240706163527 -0.3087832392674249 VNVTGIYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNVTGIYR 8 0 A0A3B3IU45;P33991;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 22202200.0 6672800.0 9102400.0 6427000.0 False True 8638071.140552485 8595843.438347323 5257351.946588874 1.0 0.9951114431082977 0.6086256828688976 23.042277767519913 -6.909659522747684 0.8980518365428511 1.0120955941055554 0.559041185077511 0.9907924139497764 0.017593969227038975 0.10464354659714831 0.13999225404260127 0.014380213943425469 0.039602799828471084 1.2312336524464316e-07 6.909659522747684 -0.4530544090280444 VNVTVDYIRPASPATETVPAFSER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNVTVDYIRPASPATETVPAFSER 24 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 26880400.0 7470000.0 12484000.0 6926400.0 False True 9793242.339582901 10621435.862250855 6209722.570720333 1.0 1.0845678575031799 0.6340823963501354 23.22335515466956 -6.858162462183122 1.1949905108981913 1.0456773817400056 0.6130215335377502 0.9513669812580998 0.04311355491235762 0.14870691550639636 0.4045633302391476 0.02815982337967799 0.06560320134658251 1.3862371641076094e-07 6.858162462183122 -0.43265584820225533 VNVTVDYIRPASPATETVPAFSER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNVTVDYIRPASPATETVPAFSER 24 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 40073900.0 11745000.0 9371900.0 18957000.0 False True 11372161.403887972 13114148.543812865 13991593.002190312 1.0 1.1531799521706871 1.2303371808816217 23.439003144503552 -13.999999999993959 0.08866985333464956 0.21099277290763563 1.4278827451786447 0.9998486026188016 0.0011778430629129134 12.175713272852633 0.08619057984070853 1.819242982131565 0.1777081114731266 1.0000000000139108e-14 13.999999999993959 1.2168899722710091 VNVTVDYIRPASPATETVPAFSER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VNVTVDYIRPASPATETVPAFSER 24 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 107061000.0 18020000.0 72095000.0 16946000.0 False True 27337657.43846383 59229083.96919398 13596615.672304338 1.0 2.1665749562674383 0.4973584771449373 24.704386288036783 -6.718789932104696 1.7634639238573415 1.710628480424044 0.5000967577762975 0.5069171581754246 0.4909718623281796 0.3576620723760132 2.1730177590241504 0.22111119071044888 0.5559064454910191 1.9107772765229894e-07 6.718789932104696 -1.2105317226477466 VNVTVDYIRPASPATETVPAFSER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNVTVDYIRPASPATETVPAFSER 24 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 39044000.0 7470000.0 13371000.0 18203000.0 False True 10231860.869159557 12780225.00801589 13903826.30255281 1.0 1.249061648848012 1.3588756219761682 23.28656521619245 -13.229060862274004 0.11843725298154065 5.486434231435566e-18 1.5449917568556308 0.9997207574701761 0.0025089424467266757 9.182588389709712 0.0985114531472144 2.2870470012104946 0.15712544002838963 5.901183748544161e-14 13.229060862274004 1.5449917568556308 VNVTVDYIRPASPATETVPAFSER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNVTVDYIRPASPATETVPAFSER 24 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 29311200.0 11745000.0 10030000.0 7536200.0 False True 9766487.891721496 9975966.399200868 9111984.57654818 1.0 1.0214487039559978 0.9329847819984395 23.219408419937828 -6.842654305990051 1.2700850532977224 1.0114089349864874 0.9299202481772122 0.9289103060154718 0.010046056811900449 0.16572228201692182 0.5181498616254274 0.006199526196044809 0.01429370578160416 1.4366325232905588e-07 6.842654305990051 -0.08148868680927523 VNVTVDYIRPASPATETVPAFSER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VNVTVDYIRPASPATETVPAFSER 24 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 0 52810000.0 18020000.0 20470000.0 14320000.0 False True 23327245.22730425 19330826.50542383 11713906.935608005 1.0 0.8286802113606341 0.5021556048074216 24.475512610129233 -6.960976510084187 0.4214534582598562 1.0142091424952135 0.3042800980027451 0.9998047004490117 0.002885965080530631 0.07935421246800113 0.019856619997051614 0.004227925827953889 0.027169843244022985 1.094015537270051e-07 6.960976510084187 -0.7099290444924684 VNYDTTESK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNYDTTESKLR 11 1 P08621-2;P08621;P08621-3;M0QYR1 P08621-2 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 1 4411000.0 1492400.0 1401800.0 1516800.0 True False 1445024.5788984592 1961546.0502904258 1119504.5769753791 1.0 1.3574482254036886 0.7747304740164187 20.46266260153341 -6.7407241291967015 1.6839912276956357 1.2125044893347956 0.774332660872562 0.6081771251367817 0.15018279951396013 0.3165254837779127 1.7627321451671316 0.0705433555159816 0.17297324892605714 1.8166692737263267e-07 6.7407241291967015 -0.43817182846223357 VNYQANIWALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VNYQANIWALK 11 0 B4DUC8;Q13126;Q13126-4;Q13126-3;Q13126-2;J3QSB7;Q13126-7;Q13126-6;Q13126-5;F2Z2F3;A0A2R8Y4K0 B4DUC8 MTAP S-methyl-5-thioadenosine phosphorylase;Purine nucleoside phosphorylase 0 30299300.0 9863700.0 10796000.0 9639600.0 False True 12931406.220206685 9185278.882478395 8642186.661572501 1.0 0.7103078138652414 0.6683098894587484 23.624375833142146 -13.999999999999998 0.27199125570011395 3.2600487955908393 0.6546360852557848 0.9995876239977971 0.002994498972808643 14.98166829343137 0.16511360959949298 18.744813994207068 0.01727085227827279 1.0000000000000041e-14 13.999999999999998 -2.6054127103350546 VNYQANIWALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VNYQANIWALK 11 0 B4DUC8;Q13126;Q13126-4;Q13126-3;Q13126-2;J3QSB7;Q13126-7;Q13126-6;Q13126-5;F2Z2F3;A0A2R8Y4K0 B4DUC8 MTAP S-methyl-5-thioadenosine phosphorylase;Purine nucleoside phosphorylase 0 28753500.0 10661000.0 3782500.0 14310000.0 False True 10322572.390536359 5292871.975476918 10561781.709202046 1.0 0.5127473826513801 1.0231734212767538 23.299299200148887 -10.984941755370965 12.672791636133095 1.1495312996082034 0.7679604019640673 0.21602324629024006 0.20838055767705052 0.07285796722799727 8.65723038145883e-05 0.01669770307228104 0.06725453579638592 1.03528100223248e-11 10.984941755370965 -0.3815708976441361 VNYQANIWALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VNYQANIWALK 11 0 B4DUC8;Q13126;Q13126-4;Q13126-3;Q13126-2;J3QSB7;Q13126-7;Q13126-6;Q13126-5;F2Z2F3;A0A2R8Y4K0 B4DUC8 MTAP S-methyl-5-thioadenosine phosphorylase;Purine nucleoside phosphorylase 0 28350200.0 9863700.0 7629500.0 10857000.0 False True 13510576.446469773 7292403.462617395 8292800.206933796 1.0 0.5397551682202911 0.6138006205575819 23.687585894665038 -10.704163704042506 6.800837498883952 1.0041175015064994 0.5767778943889648 0.9775578813231846 0.030228929333322403 0.0018976784854331725 8.254887823928243e-05 0.029431353926856203 0.009756344990136537 1.976224576688995e-11 10.704163704042506 -0.4273396071175346 VNYQANIWALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VNYQANIWALK 11 0 B4DUC8;Q13126;Q13126-4;Q13126-3;Q13126-2;J3QSB7;Q13126-7;Q13126-6;Q13126-5;F2Z2F3;A0A2R8Y4K0 B4DUC8 MTAP S-methyl-5-thioadenosine phosphorylase;Purine nucleoside phosphorylase 0 25242000.0 10661000.0 5268700.0 9312300.0 False True 8865093.862379119 5240316.467344938 11259458.87478962 1.0 0.591117990254262 1.270089076278311 23.079704475583164 -6.743658497143224 1.6734786375448607 0.7577521167242095 1.2707996857200912 0.6211890924586658 0.17178712164603155 0.31123082993665224 1.7127781560324238 0.08116700617407628 0.1983686726304975 1.8044360823008616e-07 6.743658497143224 0.5130475689958817 VPADTEVVCAPPTAYIDFAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPADTEVVCAPPTAYIDFAR 20 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 36777500.0 6153500.0 17041000.0 13583000.0 False True 8067298.090578762 14498549.225297742 12177561.457336312 1.0 1.7972001359698846 1.509496899780813 22.94365413452279 -10.088667027452288 4.352370212466148 0.999930576340945 1.6533485177964469 0.8730328106791239 0.1174543545535117 15284082.32779797 8857019.467063056 9499.25756128906 0.040207749258113774 8.153291553733425e-11 10.088667027452288 0.6534179414555019 VPADTEVVCAPPTAYIDFAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPADTEVVCAPPTAYIDFAR 20 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 23107500.0 11297000.0 3545300.0 8265200.0 False True 10938382.918665165 4960956.778495263 6100296.169314943 1.0 0.4535365798933523 0.557696344576258 23.382896136559484 -9.950167691378043 5.781234104600358 1.0000004214418483 0.5056164622346745 0.9677811231781038 0.04252304586798755 2.309767297275812e-07 4.202478351664624e-08 0.04117279708814307 0.013724254039570968 1.1215853000525386e-10 9.950167691378043 -0.4943839592071738 VPADTEVVCAPPTAYIDFAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPADTEVVCAPPTAYIDFAR 20 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 40483500.0 6153500.0 17446000.0 16884000.0 False True 8428615.242084779 16675178.033792932 12896346.936895128 1.0 1.9784006690129095 1.5300671066941807 23.006864196045683 -10.181974786789857 4.832503858366129 0.9999159774142962 1.754233887856096 0.7905116185813985 0.18303141038298662 0.00016570831539402996 2.805032745545341e-05 0.1772389811625644 0.05907313368592931 6.576960191589774e-11 10.181974786789857 0.7543179104417997 VPADTEVVCAPPTAYIDFAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPADTEVVCAPPTAYIDFAR 20 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 18879100.0 3695300.0 8716700.0 6467100.0 False True 4783638.695252911 8231607.982404887 5290154.158049622 1.0 1.7207838022076376 1.1058849748203927 22.189676997269203 -10.253962976141857 4.482908263271098 0.9998129809236647 1.4133343885179244 0.37596284808232006 0.2510313951023541 0.00046942933355347135 7.812127158070884e-05 0.24316915194653763 0.08102003438202278 5.572332513671133e-11 10.253962976141857 0.4135214075942597 VPAEGLEEVLTTPETVLTGHTEK(ub)ICSLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPAEGLEEVLTTPETVLTGHTEKICSLR 28 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 16979300.0 7985400.0 4511200.0 4482700.0 True False 7731907.847986968 6312545.685597213 3308546.3918825975 1.0 0.8164279515101449 0.42790815112262237 22.882393012351276 -6.958922997679522 0.45035497728103774 1.0124835922117652 0.21644124846605084 0.9997281469175644 0.003932357518552169 0.08008810716387169 0.022569882991040627 0.005195712981917258 0.032135312472827374 1.0992007152739274e-07 6.958922997679522 -0.7960423437457144 down VPAEGLEEVLTTPETVLTGHTEK(ub)ICSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VPAEGLEEVLTTPETVLTGHTEKICSLR 28 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 160828000.0 11903000.0 26684000.0 122241000.0 True False 18057721.2258621 21922031.716956392 98080012.76986645 1.0 1.2139976823631469 5.431472307225408 24.10611250921329 -6.917431002122169 0.8435472787331033 0.8980533252238379 6.072981873570771 0.9934373625821252 0.1652968700316838 0.09970709874155244 0.11361626969760544 0.1405159149566841 0.4111160645503367 1.209397308846085e-07 6.917431002122169 5.174928548346933 up VPAEGLEEVLTTPETVLTGHTEK(ub)ICSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VPAEGLEEVLTTPETVLTGHTEKICSLR 28 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 21588600.0 7985400.0 2738200.0 10865000.0 True False 6640213.913201598 2723448.773109853 13136821.26591598 1.0 0.4101447345988789 1.9783732026762408 22.662798287785552 -6.804812226363392 1.4360965957485325 0.676493880315378 2.0027033018934097 0.8458618640966372 0.25391392429564175 0.21397247557320961 0.8706314271432279 0.13905936840571875 0.32251342993484905 1.5674286245492064e-07 6.804812226363392 1.3262094215780316 VPAEGLEEVLTTPETVLTGHTEK(ub)ICSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPAEGLEEVLTTPETVLTGHTEKICSLR 28 1 P57737-3;A0A0A6YYL4;P57737;P57737-4;P57737-2 P57737-3 CORO7;CORO7-PAM16 Coronin-7;Coronin 1 123102000.0 11903000.0 17307000.0 93892000.0 True False 15408668.14320769 16343850.235924298 76804619.41327558 1.0 1.0606919484555741 4.984507337003809 23.87723883130574 -6.910262204786429 0.8939314036823984 0.8795156109751435 5.494476221596813 0.9910205000757786 0.1766495645499185 0.10424531922397726 0.13782272103081308 0.1448130402706387 0.40048768568909515 1.2295262216574376e-07 6.910262204786429 4.614960610621669 up VPAFLDLFMQSLFKPGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VPAFLDLFMQSLFKPGAR 18 1 X6RLT1;H0UI80;Q8IXH7-4;Q8IXH7 X6RLT1 NELFCD;TH1L Negative elongation factor C/D 0 2270400000.0 893640000.0 685850000.0 690910000.0 False True 1355717213.8351188 563454708.9294909 554351335.6633887 1.0 0.4156137453883637 0.408898942940477 30.336409135156696 VPAFLDLFMQSLFKPGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPAFLDLFMQSLFKPGAR 18 1 X6RLT1;H0UI80;Q8IXH7-4;Q8IXH7 X6RLT1 NELFCD;TH1L Negative elongation factor C/D 0 2199360000.0 893640000.0 550120000.0 755600000.0 False True 1156834596.277924 519505338.4056547 618088553.1107131 1.0 0.44907486349141484 0.5342929361720267 30.107535457249146 -10.74916083762848 6.9917838557179115 1.0089602609890231 0.4916838998317208 0.9793558278520739 0.034790132488485004 0.00484402927105077 0.00017378545456362668 0.033580091362907724 0.011228466978354326 1.7817187993646198e-11 10.74916083762848 -0.5172763611573024 VPAINVNDSVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPAINVNDSVTK 12 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 17241100.0 1082100.0 6621900.0 9537100.0 False True 1418643.5790713052 5633938.331964039 8550292.37832306 1.0 3.9713557478984374 6.027089893798685 20.436080740614322 -8.128823797964618 0.27781390604621503 3.530914433342588e-25 7.494102855784027 0.9992506619294551 0.05648953016967649 0.09341314218155207 0.06053389378364708 0.5103225773002792 0.6485277276929381 7.433206569171317e-09 8.128823797964618 7.494102855784027 VPAINVNDSVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPAINVNDSVTK 12 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 13987200.0 1082100.0 5893100.0 7012000.0 False True 1482181.6126529516 5632723.356124321 5355910.0166731 1.0 3.800292290795815 3.6135315476533107 20.499290802137214 -10.234650613515551 4.202335692175922 0.9983584958875433 3.706911919360111 0.9964425690261712 0.07624475459322042 9034273.607956339 11281889.171050468 153907.40867781136 0.02790272223874238 5.825717036385555e-11 10.234650613515551 2.7085534234725674 VPAINVNDSVTK(ub)SK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPAINVNDSVTKSK 14 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 26350200.0 8997500.0 5199700.0 12153000.0 True False 8711879.287482504 7275967.326077285 8969764.71781499 1.0 0.8351777023048998 1.029601584436899 23.054552533416082 -6.682105017690543 1.8947378774700687 0.8959085754662471 1.028867487434059 0.3335842305776585 0.06982438795104796 0.4338950290170108 3.013530534306451 0.029552825530776542 0.07772462805727473 2.0791938519357357e-07 6.682105017690543 0.13295891196781195 VPAINVNDSVTK(ub)SK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VPAINVNDSVTKSK 14 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 67316000.0 19063000.0 14038000.0 34215000.0 True False 28919964.691977635 11532809.220605394 27452390.253032796 1.0 0.3987836549400969 0.9492539339319477 24.785562455133352 -10.591721519721686 9.398863391925202 1.0000474066099014 0.6740187944360243 0.3186062316049467 0.2247285503495888 0.00022327366592096669 9.698700762620624e-06 0.21762389947841906 0.07253082774344102 2.5602270410756598e-11 10.591721519721686 -0.32602861217387713 VPAINVNDSVTK(ub)SK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VPAINVNDSVTKSK 14 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 27382300.0 8997500.0 11220000.0 7164800.0 True False 7481819.906833898 11159555.633004384 8662926.553707764 1.0 1.4915563020718048 1.1578635494547311 22.83495780885036 -10.604496790961162 5.945327668556484 0.9985542338124981 1.3247099257630301 0.5580138488535896 0.13622949579610108 0.0026212422124822364 0.0001743734780479597 0.1324389769258571 0.04396788070671104 2.4860119335138228e-11 10.604496790961162 0.32615569195053207 VPAINVNDSVTK(ub)SK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPAINVNDSVTKSK 14 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 50719000.0 19063000.0 11090000.0 20566000.0 True False 24677429.287907977 10472831.751106517 16823199.024980035 1.0 0.42438908967873085 0.6817241305285984 24.5566887772258 -10.387719832235215 5.973412402328921 1.0000983672591919 0.5530566101036729 0.8008775592799007 0.10505659050340777 0.00013765528721789024 1.4109623941200953e-05 0.10174280582686661 0.03390686878575239 4.095247631015211e-11 10.387719832235215 -0.44704175715551897 VPDDIYK(ub)THLENNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPDDIYKTHLENNR 14 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 20908500.0 5745300.0 6887400.0 8275800.0 True False 7532143.937564349 5859826.7668749215 7419499.603079135 1.0 0.7779759409071781 0.9850448510518455 22.844629139115153 -10.490747649361316 7.776565613356484 1.000012985118861 0.8815103960063146 0.3039050508015121 0.0845355285747757 1.9033678150015793e-05 1.2464462973733352e-06 0.08186013895843215 0.027283724527745645 3.230370611816402e-11 10.490747649361316 -0.11850258911254641 VPDDIYK(ub)THLENNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPDDIYKTHLENNR 14 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 34547900.0 6527100.0 8622700.0 19398100.0 True False 6319900.783253903 12065789.07678646 14317155.679473933 1.0 1.9091738131012548 2.2654082984040955 22.59147047889251 -10.167109044281117 0.21843027529068212 5.877368132526906e-19 2.52617608189881 0.999290268129923 0.014193868041650128 1.7155453137495058 0.10333968737343385 1.1875243059108862 0.19183207037508443 6.805984500367757e-11 10.167109044281117 2.52617608189881 VPDDIYK(ub)THLENNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VPDDIYKTHLENNR 14 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 176626000.0 26998600.0 53400400.0 96227000.0 True False 40958850.06204825 43870681.40077048 77207691.27220766 1.0 1.0710916281661014 1.8850063211063377 25.287671875812418 -6.9240826842891146 0.7938520026508589 0.9845440901371045 2.0294321380131297 0.9952420954484703 0.02769379603918421 0.0958285913707228 0.09359738874301159 0.02439242714190898 0.07618110919978674 1.1910152318950685e-07 6.9240826842891146 1.0448880478760252 VPDDIYK(ub)THLENNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPDDIYKTHLENNR 14 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 23074200.0 5745300.0 6379300.0 10949600.0 True False 7869492.670894572 6097441.432475925 8363529.994090665 1.0 0.7748201424759436 1.0627788021232039 22.907839200638044 -6.6980800857687 1.837590642771497 0.8599102645949357 1.0618952163126048 0.408504023082115 0.0950850646149692 0.3995427646831163 2.6215552188930267 0.04130062210369206 0.10647170498555901 2.0041024281886456e-07 6.6980800857687 0.20198495171766906 VPDDIYK(ub)THLENNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VPDDIYKTHLENNR 14 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 34711900.0 6527100.0 12893100.0 15291700.0 True False 5427572.849557709 12823642.31122002 18489123.769167736 1.0 2.362684512335014 3.406517845389106 22.371875754326787 -7.581608160941043 0.18066990694669102 5.1395057903392415e-20 5.158538252978458 0.999957180593333 0.006447636885555789 0.1374534882383428 0.019432768541282164 0.17711167798644267 0.3166631088994735 2.6205463109004836e-08 7.581608160941043 5.158538252978458 VPDDIYK(ub)THLENNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPDDIYKTHLENNR 14 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 174748800.0 26998600.0 46784200.0 100966000.0 True False 34950219.92196984 44180618.14338302 82591223.99864522 1.0 1.2641012915518428 2.363110280365591 25.058798197904867 -6.943966990695907 0.6215615988449879 0.9879836242729612 2.697607802546294 0.9986387056637774 0.021777992249650154 0.08600254048587154 0.046711745995195966 0.02190095180474211 0.09306457412670044 1.1377137564412634e-07 6.943966990695907 1.7096241782733328 up VPDGKPENEFAFNAEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPDGKPENEFAFNAEFK 17 1 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 10171600.0 2850900.0 2729500.0 4591200.0 False True 2760399.7400037637 3819403.584154465 3388626.986952374 1.0 1.3836414809071302 1.2275856057527936 21.396445771531315 -10.25396783187145 5.451602940534584 0.9999738120541253 1.3056135433299803 0.8364292851679466 0.06370954424866432 2.0280091722362973e-05 2.775307308729761e-06 0.06169178005669052 0.020562166989119113 5.572270211270914e-11 10.25396783187145 0.305639731275855 VPDGMVGFIIGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 VPDGMVGFIIGR 12 0 Q96AE4;E9PEB5;Q96AE4-2;C9JSZ1 Q96AE4;Q96AE4-2 FUBP1 Far upstream element-binding protein 1 0 15754360.0 3747360.0 5520100.0 6486900.0 False True 4912825.249485864 4696522.597181266 5815697.814738638 1.0 0.9559718407799597 1.183778685257991 22.228121492275527 -6.856590837617366 1.2027007043654552 0.9762935531114867 1.1941202443576364 0.9493707788230689 0.022200043286872976 0.15036180300671498 0.4152191943114468 0.01441438973764766 0.033531725318699974 1.3912627660202585e-07 6.856590837617366 0.21782669124614973 VPDGMVGFIIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPDGMVGFIIGR 12 0 Q96AE4;E9PEB5;Q96AE4-2;C9JSZ1 Q96AE4;Q96AE4-2 FUBP1 Far upstream element-binding protein 1 0 7814600.0 0.0 2838500.0 4976100.0 False True 0.0 3971927.852581951 3672710.1301998785 0.0 VPDGMVGFIIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VPDGMVGFIIGR 12 0 Q96AE4;E9PEB5;Q96AE4-2;C9JSZ1 Q96AE4;Q96AE4-2 FUBP1 Far upstream element-binding protein 1 0 16915220.0 3747360.0 5686460.0 7481400.0 False True 5132860.260596223 5435213.394591428 5714447.404269548 1.0 1.0589053897134704 1.1133066388224193 22.29133155379842 -6.972079830918732 0.20245479946000933 0.9686271970928078 1.205090830557109 0.9999943657066793 0.00010967632869089264 0.07563358911307919 0.006556853320855991 0.0017310598449886317 0.005739992401523369 1.066400080233848e-07 6.972079830918732 0.23646363346430133 VPDGMVGFIIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VPDGMVGFIIGR 12 0 Q96AE4;E9PEB5;Q96AE4-2;C9JSZ1 Q96AE4;Q96AE4-2 FUBP1 Far upstream element-binding protein 1 0 5040000.0 0.0 2141000.0 2899000.0 False True 0.0 2129466.0080447737 3505167.4965384603 0.0 VPDGMVGLIIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPDGMVGLIIGR 12 0 A0A087WTP3;Q92945;M0QYH3;M0QXW7 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 27165700.0 7194800.0 9092900.0 10878000.0 False True 9432452.474542314 7736274.7638466 9752448.9091441 1.0 0.8201763841086285 1.03392505135493 23.16920149535189 -6.683557976549297 1.8887497508142588 0.8865954499221944 1.033146477433961 0.3407766704044294 0.0761538086803979 0.43062453581160365 2.972932168997921 0.03231339959236514 0.08485337896618313 2.072249404238494e-07 6.683557976549297 0.14655102751176652 VPDGMVGLIIGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 VPDGMVGLIIGR 12 0 A0A087WTP3;Q92945;M0QYH3;M0QXW7 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 28846100.0 9843400.0 6195800.0 12806900.0 False True 9530926.65500475 8669815.250670167 9452388.691235479 1.0 0.9096508203761691 0.9917596717914067 23.184185057917734 -10.227231695479738 5.166028370064054 1.000005019439545 0.9507052463892746 0.32458622716891783 0.03352079822228487 1.938093432046871e-06 2.89949818698301e-07 0.032459678232966305 0.010818791105531673 5.926090841388887e-11 10.227231695479738 -0.049299773050270335 VPDGMVGLIIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPDGMVGLIIGR 12 0 A0A087WTP3;Q92945;M0QYH3;M0QXW7 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 30748100.0 7194800.0 9843300.0 13710000.0 False True 9854911.992159199 9408390.458559768 10471980.3663132 1.0 0.954690459543962 1.0626153104812053 23.23241155687478 -6.792693424453896 1.4858710243711184 0.9747647945907694 1.0638446606343828 0.8098351651450166 0.019295858309853205 0.23136291923222943 1.0090812878197892 0.010220832453895344 0.02388009514655699 1.611783017558355e-07 6.792693424453896 0.0890798660436134 VPDGMVGLIIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VPDGMVGLIIGR 12 0 A0A087WTP3;Q92945;M0QYH3;M0QXW7 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 21126800.0 9843400.0 4757900.0 6525500.0 False True 8185223.236557795 4732268.248330791 7889951.879496983 1.0 0.5781477317802384 0.9639262914978255 22.96459033335201 -10.4121935180588 8.623872674200456 1.0000019525269068 0.7710370116390319 0.31957529801125517 0.15749343750231623 5.912435854815493e-06 4.030164467331146e-07 0.15249366582410437 0.05083078838195246 3.8708512453124294e-11 10.4121935180588 -0.2289649408878749 VPDVDIK(ub)GPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPDVDIKGPK 10 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 4548900.0 1838500.0 1521100.0 1189300.0 True False 2379974.492252993 1436449.4478456373 972859.6032485057 1.0 0.6035566568135058 0.4087689201776076 21.18251468063163 -12.785410350086064 0.10488830745384903 2.538446325265949 2.289538235499798e-17 0.99980906884995 0.0033992316335242434 7.792496488881382 0.08483823589821438 2.8651138986272513 0.3296468647215679 1.6390403678230257e-13 12.785410350086064 -2.538446325265949 VPEAVALERR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPEAVALERR 10 1 K7ENT7;Q96J92-3;Q96J92 K7ENT7 WNK4 Serine/threonine-protein kinase WNK4 0 7396800.0 1505300.0 1358700.0 4532800.0 False True 1973462.8773459357 1155987.256171119 4063789.337687849 1.0 0.5857658988375699 2.059217522831311 20.912297950388155 -6.83163710525227 1.3205468795957147 0.7788996810183326 2.100219071781241 0.9091170757348441 0.18704491202908602 0.17879802736453226 0.6092062021725526 0.11119163257865906 0.2558821368917872 1.4735432750669215e-07 6.83163710525227 1.3213193907629084 up VPEAVALERR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPEAVALERR 10 1 K7ENT7;Q96J92-3;Q96J92 K7ENT7 WNK4 Serine/threonine-protein kinase WNK4 0 10769600.0 2168700.0 2451000.0 6149900.0 False True 2099855.80558636 3429697.08179615 4539056.696954697 1.0 1.6333012355762437 2.1616039943691367 21.001858832592788 -6.973211759864565 0.16424068466615238 0.49539684734368006 3.3135802988921093 0.9999978243004701 0.0007004187685389446 0.07527360557590006 0.005092043796807833 0.023488507133595654 0.06243304816314745 1.0636242737739169e-07 6.973211759864565 2.818183451548429 VPEAVALERR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPEAVALERR 10 1 K7ENT7;Q96J92-3;Q96J92 K7ENT7 WNK4 Serine/threonine-protein kinase WNK4 0 11382200.0 1505300.0 1394600.0 8482300.0 False True 2061850.0892029288 1332981.9606745143 6478955.438452112 1.0 0.6464980008269269 3.142301893032752 20.975508011911046 -6.8710102332198675 1.1286659681981759 0.7987735212059562 3.291348093758069 0.9656847085161964 0.2042677859448641 0.1358936092600585 0.3229198759439227 0.14036198334053016 0.3329261380152152 1.3458286421111054e-07 6.8710102332198675 2.4925745725521127 up VPEAVALERR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VPEAVALERR 10 1 K7ENT7;Q96J92-3;Q96J92 K7ENT7 WNK4 Serine/threonine-protein kinase WNK4 0 12276300.0 2168700.0 6043500.0 4064100.0 False True 1803370.1396999888 6010942.465959168 4913884.519724726 1.0 3.333171784112582 2.724834137789487 20.782264108027064 -10.160585423018828 5.236889351908102 0.9999184702393885 3.0290029609521603 0.9368388293122074 0.2483528041402268 0.00023644127280384654 3.789834360071662e-05 0.2404759981238668 0.08015552286767269 6.908990205063002e-11 10.160585423018828 2.029084490712772 VPEEDLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPEEDLKR 8 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 4201300.0 1495100.0 1452900.0 1253300.0 True False 1960090.5785689936 1236132.983359842 1123620.5385025102 1.0 0.6306509489282417 0.5732492930621775 20.902488894191627 -13.999999999999998 0.26206794303562286 3.7332133431144725 0.5526812270971422 0.9995665816323572 0.003936815731811678 14.50943956527398 0.16200465357547028 21.02812515354041 0.024824685851903 1.0000000000000041e-14 13.999999999999998 -3.1805321160173303 VPEEDLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPEEDLKR 8 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 8287100.0 2103500.0 2563500.0 3620100.0 True False 2036725.5438976844 3587118.918475899 2671887.2093279017 1.0 1.7612186036667585 1.3118543229023913 20.95782015437278 -10.185333937128686 4.397624385617103 0.9998619847644703 1.5365364633007146 0.6552694372296906 0.18345219947599195 20234284.422680553 46864666.75714548 16410.099813759214 0.06280056781996786 6.526285414093487e-11 10.185333937128686 0.5366744785362443 VPEEDLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 VPEEDLKR 8 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 38139000.0 3841400.0 6200600.0 28097000.0 True False 5827684.643957549 5094054.484491078 22543615.634647436 1.0 0.8741129274681778 3.8683657424774776 22.474491379652452 -6.897086286957898 0.9795158880954237 0.8653633238437953 4.164697476764802 0.9850597480856171 0.16901860263360596 0.11358150846480028 0.18976732470510885 0.13009343192486006 0.33379010475432946 1.2674000299209456e-07 6.897086286957898 3.299334152921007 up VPEEDLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPEEDLKR 8 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 5326200.0 1495100.0 1414300.0 2416800.0 True False 2047878.873558292 1351811.5495353257 1846001.615558408 1.0 0.6601032741680105 0.9014212898006452 20.96569895571452 -10.101793043766879 5.708051527207036 1.0000016364535582 0.7807622819843024 0.5239227280729611 0.09851766734024497 2.051706329482874e-06 3.227330735224499e-07 0.09539003331541425 0.03179644040965114 7.910555033057062e-11 10.101793043766879 -0.2192393544692558 VPEEDLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VPEEDLKR 8 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 8304300.0 2103500.0 3544400.0 2656400.0 True False 1749153.4508502448 3525305.6136916797 3211840.958194129 1.0 2.0154353021331928 1.836225950692255 20.738225429807056 -10.210574622863499 4.600583136962161 0.999784193610544 1.9258306264197869 0.9726672205774748 0.07316191138670228 0.0001622232435268853 2.7836446198246285e-05 0.07085487134505991 0.02361290536114221 6.157797133717947e-11 10.210574622863499 0.9260464328092428 VPEEDLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPEEDLKR 8 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 48492200.0 3841400.0 6908800.0 37742000.0 True False 4972768.025314462 6524319.206676707 30873343.265622728 1.0 1.3120095635798594 6.208482500783936 22.2456177017449 -6.919883767295574 0.8255960947983304 0.8915097818394526 6.99595590017851 0.9941484311729354 0.18245446470011595 0.09824009734914807 0.10597146542667783 0.15710653687685974 0.47008163392652946 1.2025862465542343e-07 6.919883767295574 6.104446118339057 up VPEIEVTVEGPNNNNPQTSAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VPEIEVTVEGPNNNNPQTSAVR 22 0 A0A494C1K3;P78347-2;P78347-4;P78347-3;P78347 A0A494C1K3 GTF2I General transcription factor II-I 0 30570200.0 4399100.0 16508000.0 9663100.0 False True 6673756.317288922 13562018.422407314 7753184.049512818 1.0 2.032141687174549 1.1617421555275473 22.670067578850535 -10.279726711944981 4.742524237439613 0.9997813481311716 1.596941921244382 0.3854253303908025 0.35533912087032543 0.0008610519222122899 0.00013077158166680032 0.3441854590678837 0.11468520810732866 5.2513780924459546e-11 10.279726711944981 0.5971605731132105 VPEQK(ub)EVQDGIAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPEQKEVQDGIAPR 14 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 4099400.0 1659800.0 0.0 2439600.0 True False 2176013.873526064 0.0 2187173.5942956395 1.0 0.0 1.0051285154499001 21.053256324075775 -12.035630429224279 14.418147734268866 0.8765978710024165 0.552307831952468 0.0 0.48666168603737325 0.0 0.0 0.0 0.1396327749377105 9.212331783955458e-13 12.035630429224279 -0.32429003904994846 VPEQK(ub)EVQDGIAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPEQKEVQDGIAPR 14 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 13006800.0 2814500.0 3299300.0 6893000.0 True False 2725155.2380794063 4616727.695622204 5087516.514432544 1.0 1.6941154878486524 1.8668721852403707 21.377906984471807 -11.103702605077215 0.2608494757071558 6.732280510505983e-10 1.9414494615793612 0.9992435353095614 0.010303703409291412 3.1383272199836414 0.13899759503881426 1.9317926943295969 0.07470710174317313 7.875849252138412e-12 11.103702605077215 1.941449460906133 VPEQK(ub)EVQDGIAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPEQKEVQDGIAPR 14 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 7698100.0 1659800.0 2371600.0 3666700.0 True False 2273472.9144084384 2266814.870167561 2800700.9780569407 1.0 0.9970714213489498 1.2319042643117162 21.116466385598667 -6.904078461756274 0.9351403436710598 0.9912987289792077 1.2587001010837244 0.9884879812690002 0.011804223290124349 0.10846468193734603 0.1609793361068056 0.009389810835006923 0.02497008065594631 1.2471581762179896e-07 6.904078461756274 0.26740137210451675 VPEQK(ub)EVQDGIAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VPEQKEVQDGIAPR 14 1 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 11757700.0 2814500.0 4607100.0 4336100.0 True False 2340381.453490855 4582280.6378622465 5242758.462138812 1.0 1.9579204197791902 2.2401298960555525 21.158312259906083 -10.483048193751376 0.2620510842578762 1.636647971384974e-11 2.3706977157117124 0.9991229115253243 0.01571825988505327 2.097852145341897 0.12877233244596703 1.5082053396369883 0.12036734445585269 3.288151401650254e-11 10.483048193751376 2.370697715695346 VPFCLQSCVKPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPFCLQSCVKPLK 13 1 O94925-3;O94925;H7BZD1 O94925-3 GLS Glutaminase kidney isoform, mitochondrial 0 10439800.0 3317100.0 3252300.0 3870400.0 False True 4348750.222842098 2767069.517366108 3469928.1354983747 1.0 0.6362907445987338 0.7979138735704681 22.052169417097062 -10.035747648162106 4.551616047016135 1.0000097449812688 0.7171023090697644 0.8033426044865125 0.06598236617300181 45637243.426059626 1.8654144828801822 5526.126743350034 0.022587518958407667 9.209845650527325e-11 10.035747648162106 -0.28290743591150447 VPFCPMVGSEVYSTEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPFCPMVGSEVYSTEIK 17 0 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 0 7220400.0 1566000.0 3100800.0 2553600.0 False True 2053041.1651655727 2638172.7268237323 2289377.9678608594 1.0 1.285007223228751 1.1151154719667917 20.969331124284 -10.225434889893197 3.827328446644302 0.9997859235384111 1.2000613475943585 0.6489910523174067 0.06935801728680198 16292922.374707164 12.068584370637259 31171.094728942484 0.02374309409327023 5.95065963290131e-11 10.225434889893197 0.20027542405594734 VPFCPMVGSEVYSTEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPFCPMVGSEVYSTEIK 17 0 Q9Y265;Q9Y265-2;E7ETR0 Q9Y265 RUVBL1 RuvB-like 1 0 7556100.0 1566000.0 2751500.0 3238600.0 False True 2144992.519558751 2629929.632006259 2473709.3810606836 1.0 1.2260786963244352 1.1532484885166654 21.032541185806892 -10.082215086209402 4.247067671701514 0.9999768197640353 1.1896635924549819 0.9004221784905261 0.029732807946438698 27546879.53779842 18607707.253517147 7353.590109532966 0.010881092521485475 8.275322233167876e-11 10.082215086209402 0.18968677269094658 VPFIHVGNQVVSELGPIVQFVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPFIHVGNQVVSELGPIVQFVK 22 0 O75431-2;O75431;C9JNK6;C9JAZ1 O75431-2 MTX2 Metaxin-2 0 26496000.0 17980000.0 0.0 8516000.0 False True 23275464.438786387 0.0 6966175.381538957 1.0 0.0 0.29929264783780113 24.472306619830142 -10.331489728109323 5.677151254196621 1.0001362591467269 0.14964632391894522 0.9149899094158378 0.12218571182820545 0.00021075928532500161 2.4817838423307763e-05 0.11832438317545317 0.039435268921258586 4.6613345281441515e-11 10.331489728109323 -0.8504899352277817 VPFIMCCGGK(ub)SSEDATDDISSGNIPVLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VPFIMCCGGKSSEDATDDISSGNIPVLQK 29 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 99026000.0 14185000.0 54111000.0 30730000.0 True False 21519682.062409 44454469.27882733 24656202.03056251 1.0 2.0657586459644435 1.1457512224882005 24.359153427497606 -6.610493115066175 2.152077103514673 1.7118179800472646 1.1490680660851846 0.05181542730380784 0.45943037618537286 0.6113369362400503 5.366180775934107 0.17625592167571963 0.5099614337643954 2.4519233241998226e-07 6.610493115066175 -0.56274991396208 VPFIMCCGGK(ub)SSEDATDDISSGNIPVLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPFIMCCGGKSSEDATDDISSGNIPVLQK 29 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 77695400.0 14185000.0 53996000.0 9514400.0 True False 18362762.128152687 50991075.13370132 7782876.825988046 1.0 2.776873913512437 0.4238402028884209 24.130279749590056 -6.7046754331879095 1.8139715285244968 2.0982198720837744 0.430106472533917 0.44000285541283546 0.7494100699363143 0.3858129055861169 2.4711676334675543 0.32917785603235883 0.8417775064866956 1.973897362811432e-07 6.7046754331879095 -1.6681133995498574 VPFLVLECPNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPFLVLECPNLK 12 0 Q9NRP0;A0A087WUD3;Q9NRP0-2 Q9NRP0 OSTC Oligosaccharyltransferase complex subunit OSTC 0 5803700.0 2056600.0 1673400.0 2073700.0 False True 2696222.5161427287 1423735.2428621112 1859133.4163350023 1.0 0.5280481244919414 0.6895326350863343 21.36250813471948 -10.247249228993466 6.393338332151151 1.0000060230874268 0.6087903797891377 0.8866882581816538 0.06592577538655518 5.659939001637033e-06 6.663888770249193e-07 0.06383333960579207 0.021277452513161498 5.659144339723376e-11 10.247249228993466 -0.39121564329828906 VPFLVLECPNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPFLVLECPNLK 12 0 Q9NRP0;A0A087WUD3;Q9NRP0-2 Q9NRP0 OSTC Oligosaccharyltransferase complex subunit OSTC 0 5693500.0 2056600.0 1670300.0 1966600.0 False True 2816980.5975252385 1596500.6230565344 1502129.5833983636 1.0 0.5667417888710647 0.5332410115703345 21.42571819624237 -13.999999999999998 0.3629973185739485 6.77584473180594 0.529378722071858 0.9997786714694434 0.003162519692648558 22.024052984332137 0.19496009052420782 98.6801601510323 0.009573481539769021 1.0000000000000041e-14 13.999999999999998 -6.246466009734082 VPFSLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPFSLLR 7 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 10027200.0 2494100.0 4532000.0 3001100.0 False True 3269789.252898761 3855843.265597636 2690574.960583969 1.0 1.1792329619345716 0.8228588304884475 21.640766222296502 -6.769982240085415 1.5746704903860889 1.1028060669672934 0.820862732363271 0.7304421006419977 0.07553688496208112 0.26645685944108677 1.3039400908272003 0.037812421845188716 0.09000525887865812 1.6983131013729503e-07 6.769982240085415 -0.28194333460402243 VPFSLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPFSLLR 7 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 10188600.0 3856800.0 2139700.0 4192100.0 False True 3734367.995105587 2994093.36838809 3094063.2496957276 1.0 0.8017670921323954 0.8285373197689493 21.83243267111288 -10.015806368577472 6.980403739471968 1.0000000249313208 0.8151522059955116 0.9845133115628225 0.010928899667952224 4.24282544464594e-09 5.986150699692259e-10 0.01058186309956507 0.003527287200529128 9.642588453304355e-11 10.015806368577472 -0.18484781893580915 VPFSLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPFSLLR 7 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 12906800.0 2494100.0 4621900.0 5790800.0 False True 3416236.1705181906 4417689.175420576 4423132.305269619 1.0 1.293145132513037 1.294738444443874 21.703976283819394 VPFSLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VPFSLLR 7 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 9662400.0 3856800.0 2651100.0 3154500.0 False True 3207100.08521 2636817.9980978523 3814091.365239939 1.0 0.822181387558784 1.1892648386089246 21.612837946547156 -6.774984564472231 1.5553666781078046 0.8986586379168929 1.1917304470473564 0.7492581585975293 0.07505384576674182 0.2584463786077475 1.2345149940968938 0.03802070170353788 0.09009794032081418 1.6788636865909045e-07 6.774984564472231 0.2930718091304635 VPFSLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPFSLLR 7 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 10502200.0 3327500.0 3478900.0 3695800.0 False True 4307514.344831015 3285296.156801119 3023202.3221103405 1.0 0.7626895452463088 0.7018438199139512 22.038424170227586 -13.999999999999998 0.19109893490486857 2.2769934914529375 0.658671881876061 0.9994888393092711 0.0029082159796774195 12.36882272723632 0.13862973341196266 5.883638176141302 0.041481628282964686 1.0000000000000041e-14 13.999999999999998 -1.6183216095768764 VPHLGFK(ub)QINLWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPHLGFKQINLWK 13 1 Q03989;Q03989-5;A0A669KBH0 Q03989 ARID5A AT-rich interactive domain-containing protein 5A 1 12892000.0 2513500.0 4369600.0 6008900.0 True False 3442808.8747834773 4176536.6236651097 4589721.577180117 1.0 1.213118931537487 1.3331328412672256 21.71515466221122 -12.679942896452008 0.07601610120607497 1.4414658796480159e-16 1.7455682217724582 0.9999266736663057 0.0011796362445743954 7.714841438056903 0.0643830350956456 1.5475256752644684 0.33312903451372794 2.0895708616432355e-13 12.679942896452008 1.745568221772458 VPHWYHFSCFWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPHWYHFSCFWK 12 0 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 9995700.0 2293900.0 3975700.0 3726100.0 False True 3007325.1141592013 3382541.0571572236 3340558.915275042 1.0 1.1247673360061459 1.1108073748152125 21.520049411705962 -10.048123565014306 4.521366380184849 0.9999941478350933 1.1177873554184414 0.9895748706720704 0.005699130317547921 664552.236897138 1476877.1272598794 21.546705763546328 0.0019509641270012096 8.95110053534635e-11 10.048123565014306 0.1177932075833481 VPHWYHFSCFWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPHWYHFSCFWK 12 0 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 13297800.0 5559100.0 4212800.0 3525900.0 False True 5382629.4133974975 5894993.009461782 2602361.015267329 1.0 1.0951883469422954 0.48347393353701595 22.359879670539225 -6.867156079478635 1.1491174557688635 1.0530059161101832 0.4495456727417801 0.9617569645381178 0.052556908690419304 0.1396063538991075 0.3463363269291834 0.035554909460231 0.08378145044378915 1.3578253750777437e-07 6.867156079478635 -0.6034602433684031 down VPHWYHFSCFWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VPHWYHFSCFWK 12 0 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 92879600.0 4714800.0 21863800.0 66301000.0 False True 7152696.298050459 17962034.067350905 53196578.28923932 1.0 2.5112256020497674 7.437276248362257 22.770055755628363 -6.9495711371318185 0.5635316014880573 0.936725407128683 9.248632182425387 0.9991672016561775 0.07931690731758971 0.08365839661371775 0.03667850321145796 0.08466505164604736 0.40980991919561527 1.123126987193126e-07 6.9495711371318185 8.311906775296704 VPHWYHFSCFWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPHWYHFSCFWK 12 0 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 59478600.0 2293900.0 27320700.0 29864000.0 False True 3142016.8203166164 26113581.136526745 22810738.26838638 1.0 8.311088905595138 7.2599032955169776 21.583259473228853 -10.451184294545577 6.650766563057253 0.998481074909149 7.785496100556057 0.982318896529685 0.42914472827462197 0.00966216458256763 0.0007973136342104326 0.4153843377430175 0.1385058654766931 3.538471528093266e-11 10.451184294545577 6.787015025646908 VPHWYHFSCFWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPHWYHFSCFWK 12 0 P09874;Q5VX84;Q5VX85 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 106457800.0 4714800.0 39963000.0 61780000.0 False True 6103401.542602334 37739023.91969973 50536673.91633116 1.0 6.183277252246585 8.280083419643994 22.541182077720812 -8.868841067972781 0.3995991503979174 1.6566488964876473e-20 8.680738843698391 0.9973444196516977 0.157679715708461 0.3805427146418854 0.14079981288173685 1.1934205744097126 0.5241291530500922 1.3525674508033039e-09 8.868841067972781 8.680738843698391 VPK(ub)TAENFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPKTAENFR 9 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 4610800.0 1682900.0 1922800.0 1005100.0 True False 2206298.197226782 1635925.7350156973 901101.8935999954 1.0 0.741479885661867 0.4084225308857344 21.07319636414564 -6.967661719642049 0.3089764463665317 1.0519344003446336 0.08739674755617195 0.9999579715138103 0.0015698241401769565 0.07706895970900886 0.0117320851227219 0.0052941898248354494 0.029598616912332017 1.0773040198094607e-07 6.967661719642049 -0.9645376527884616 down VPK(ub)TAENFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPKTAENFR 9 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 4824500.0 1794100.0 1576300.0 1454100.0 True False 1737147.2775406877 2205724.8102959073 1073227.5879350586 1.0 1.2697396696373342 0.6178103617411457 20.72828864206581 -6.794343947089096 1.4788758434195919 1.1499146280654882 0.6100191081139297 0.8150839443229165 0.11501516607422788 0.2289510604890034 0.9890452410112627 0.06120021268031095 0.14284833710840159 1.60566911167604e-07 6.794343947089096 -0.5398955199515585 VPK(ub)TAENFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPKTAENFR 9 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 4450600.0 1682900.0 1475900.0 1291800.0 True False 2305113.608662465 1410689.857851366 986703.4454561194 1.0 0.6119827901540672 0.42804981140545645 21.136406425668532 -13.999999999999998 0.09921837016082204 2.9207125735436246 0.03150149109434152 0.9997976269598998 0.0033914384062467577 12.086412302384014 0.09364698764213371 4.762857867662694 0.35383003386768724 1.0000000000000041e-14 13.999999999999998 -2.889211082449283 VPK(ub)TAENFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VPKTAENFR 9 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 5518580.0 1794100.0 2849800.0 874680.0 True False 1491873.642106216 2834447.561758992 1057571.5439366219 1.0 1.8999246864884214 0.7088881484919529 20.508693917500086 -6.704585400318014 1.8142927237424746 1.5562780947446875 0.7120798941895967 0.43947788962825474 0.3795593560254171 0.3860511642768854 2.4735101413164666 0.16669436569856932 0.42631978970899276 1.9743066106239184e-07 6.704585400318014 -0.8441982005550908 VPLALFALNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPLALFALNR 10 0 A0A494C194;K7ES25;A0A494C165;P12955-3;P12955-2;P12955 A0A494C194 PEPD Xaa-Pro dipeptidase 0 8573500.0 2922300.0 3007900.0 2643300.0 False True 3831163.5995934536 2559133.044702368 2369796.6723240116 1.0 0.6679780119475796 0.6185579421811911 21.869351202833997 -13.999999999999998 0.2682268565453211 3.5384438961430904 0.6018696621919052 0.9995795292483061 0.0034730136288523288 14.796757856412603 0.16393280623386053 20.459965651338106 0.02070860207148694 1.0000000000000041e-14 13.999999999999998 -2.9365742339511853 VPLALFALNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPLALFALNR 10 0 A0A494C194;K7ES25;A0A494C165;P12955-3;P12955-2;P12955 A0A494C194 PEPD Xaa-Pro dipeptidase 0 2724160.0 1569400.0 665460.0 489300.0 False True 1519580.2560461287 931181.6483280566 361137.65131464467 1.0 0.6127887254543201 0.23765618819917195 20.53524144157966 -7.5966881242017035 0.3268063404203742 1.0761153130897867 1.5890658374228285e-12 0.9994321616957572 0.007416613293030647 0.12486089167495289 0.04110604128263714 0.02632734158613562 0.07145823265767844 2.531114989681954e-08 7.5966881242017035 -1.0761153130881975 down VPLALFALNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPLALFALNR 10 0 A0A494C194;K7ES25;A0A494C165;P12955-3;P12955-2;P12955 A0A494C194 PEPD Xaa-Pro dipeptidase 0 8903900.0 2922300.0 2230700.0 3750900.0 False True 4002753.2821880803 2132140.298061554 2865014.6722103683 1.0 0.5326684278917218 0.7157609950529417 21.932561264356888 -10.129953162283131 5.23097438050359 1.0000105620217172 0.6242147114720149 0.8488659680875655 0.07474722754131506 9.207431770565905e-06 1.5314913404928413e-06 0.07237572465585715 0.024124563953398005 7.413901943121008e-11 10.129953162283131 -0.3757958505497023 VPLEVQEADEAK(ub)LQQTEAELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPLEVQEADEAKLQQTEAELR 21 1 P26640;A0A140T936 P26640 VARS Valine--tRNA ligase 1 14328700.0 5451500.0 5018700.0 3858500.0 True False 5278445.116500228 7022693.082174755 2847843.097481205 1.0 1.3304473054426713 0.5395231047451741 22.331681583552328 -6.79324586588182 1.4835435770397964 1.183913131847919 0.5303681345078141 0.8115961026553883 0.1407835055552856 0.23055525453261613 1.002368915797424 0.07468454034685111 0.17443502209534922 1.6097340630697685e-07 6.79324586588182 -0.653544997340105 VPLILNLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPLILNLIR 9 0 Q15648-3;Q15648 Q15648-3 MED1 Mediator of RNA polymerase II transcription subunit 1 0 1690960.0 134390.0 641510.0 915060.0 False True 184077.61475319316 613165.9670101156 698941.6742522652 1.0 3.3310186457611035 3.7969944101535074 17.489954669032603 -9.8838469745871 0.4040788031003742 1.1365655486934667e-24 3.846416675732903 0.99878322927499 0.04268062095652326 1.2057754609485807 0.1782101841175334 1.627354937079127 0.11685370547191064 1.306631203806425e-10 9.8838469745871 3.846416675732903 VPLK(ub)CLAQEVNIPDWIVDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPLKCLAQEVNIPDWIVDLR 20 1 Q9Y4W2;Q9Y4W2-2;Q9Y4W2-3;Q9Y4W2-4 Q9Y4W2 LAS1L Ribosomal biogenesis protein LAS1L 1 89331000.0 25265000.0 22151000.0 41915000.0 True False 32706040.54760503 20918277.377706096 34286900.08421858 1.0 0.6395845240654752 1.048335399520848 24.96305377893365 -6.673930671886122 1.92359421701972 0.7707261227913478 1.046708351174737 0.2964845938754822 0.1529601398171382 0.4521679392243345 3.229295565625215 0.06393405416062858 0.1699354462519441 2.1186993244515353e-07 6.673930671886122 0.27598222838338926 VPLPSLSPTMQAGTIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPLPSLSPTMQAGTIAR 17 0 P10515;H0YDD4;E9PEJ4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 15821200.0 3068600.0 6492300.0 6260300.0 False True 4022964.3163646758 5523674.146787195 5612544.209037951 1.0 1.3730358294051748 1.3951265205627497 21.939827510660315 -11.907848295467437 0.44401595214280026 6.88400007762528e-14 1.395330311534706 0.9998154620696724 0.0024626147588349395 5.541627209563979 0.22211099991779196 5.214864657855669 0.00505364188982725 1.2363792408635367e-12 11.907848295467437 1.3953303115346372 VPLPSLSPTMQAGTIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPLPSLSPTMQAGTIAR 17 0 P10515;H0YDD4;E9PEJ4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 9887400.0 3474900.0 1561000.0 4851500.0 False True 3364591.201564097 2184315.4405074627 3580746.608119755 1.0 0.6492067860999102 1.0642441811222636 21.6819997971008 -6.682658092490477 1.8922847596868204 0.7785834804307664 1.062705008547113 0.33640415185037975 0.14858840678815602 0.43264359923123186 2.997397380790869 0.06295307849025907 0.1654808684864854 2.0765476801541742e-07 6.682658092490477 0.2841215281163466 VPLPSLSPTMQAGTIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPLPSLSPTMQAGTIAR 17 0 P10515;H0YDD4;E9PEJ4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 14135500.0 3068600.0 5135500.0 5931400.0 False True 4203144.345796929 4908596.629172503 4530525.481017513 1.0 1.1678391759447935 1.0778895770134471 22.003037572183207 -10.431872478358184 4.896354148846152 0.9997969175318664 1.1228643764791382 0.7132753693615732 0.03672176999169445 8.15427879506214e-05 9.461417093936324e-06 0.0356142869916821 0.011851900301748798 3.6993678816296916e-11 10.431872478358184 0.12306745894727178 VPLPSLSPTMQAGTIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VPLPSLSPTMQAGTIAR 17 0 P10515;H0YDD4;E9PEJ4 P10515 DLAT Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial;Acetyltransferase component of pyruvate dehydrogenase complex 0 4808000.0 3474900.0 1333100.0 0.0 False True 2889533.314171395 1325918.3257003687 0.0 1.0 0.4588693680040129 0.0 21.462405072535077 -8.062646053443396 0.5686537251775443 1.0178794358335808 2.2273894359846824e-18 0.9900872846104076 0.04069208500888959 0.11359936328810345 0.16741331012173238 0.04799683613898275 0.07532731316553345 8.656731481050521e-09 8.062646053443396 -1.0178794358335808 VPLSEFDFSWSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPLSEFDFSWSK 12 0 Q9NVP1 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 5802100.0 2112600.0 1262200.0 2427300.0 False True 2045536.6693787766 1766203.042286044 1791517.3125608733 1.0 0.8634423761381088 0.8758177447412624 20.964047969300918 -10.515422678381102 6.160570244487195 1.0001348667324248 0.8696300604396856 0.9932872872082057 0.005052223076097613 9.368228301540398e-06 7.368880389372869e-07 0.004896836760058831 0.00163059798625424 3.0519493486361546e-11 10.515422678381102 -0.1305048062927392 VPNACLFTINK(ub)EDHTLGNIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VPNACLFTINKEDHTLGNIIK 21 1 P52435;A0A0B4J2F8;F6S314;E2QRJ6;D6RAG0;E7EP90;A0A0B4J1Z8;H0Y980;E7EWC6 P52435;E7EWC6 POLR2J;POLR2J3 DNA-directed RNA polymerase II subunit RPB11-a 1 125768600.0 6056600.0 24364000.0 95348000.0 True False 9188304.996770272 20016053.843199123 76502426.00748707 1.0 2.178427234428423 8.326065148509763 23.13136731568138 -6.938862869908125 0.6700592125052299 0.9294513956020686 9.929861441624418 0.9980111291925522 0.1432454626352226 0.08828927157780295 0.05700099735891566 0.13826541526478417 0.5318207599325591 1.1511638158050342e-07 6.938862869908125 9.000410046022349 VPNACLFTINK(ub)EDHTLGNIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPNACLFTINKEDHTLGNIIK 21 1 P52435;A0A0B4J2F8;F6S314;E2QRJ6;D6RAG0;E7EP90;A0A0B4J1Z8;H0Y980;E7EWC6 P52435;E7EWC6 POLR2J;POLR2J3 DNA-directed RNA polymerase II subunit RPB11-a 1 139273600.0 6056600.0 27154000.0 106063000.0 True False 7840388.093434581 25642856.029715654 86760622.29828168 1.0 3.2706105519430326 11.065858126453419 22.90249363777383 -6.948386490251291 0.5762852876740561 0.9054649325494685 13.814116690510623 0.999068504770764 0.13156583028084473 0.08414018988856774 0.038694170656407935 0.13840701051438176 0.6505347629874206 1.1261947792936289e-07 6.948386490251291 12.908651757961154 VPNCNVVPHFNK(ub)IQDFNDTFYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPNCNVVPHFNKIQDFNDTFYR 22 1 F8W8D4;Q8TBC4-2;Q8TBC4 F8W8D4 UBA3 NEDD8-activating enzyme E1 catalytic subunit 1 88335000.0 22067000.0 40891000.0 25377000.0 True False 28930050.697132017 34790222.19186959 22751231.473372888 1.0 1.202563471322175 0.7864221086770626 24.786065515665598 -6.774324969622175 1.5577002911684301 1.1155412166872072 0.7836776550116931 0.7468946741821401 0.08548041120283219 0.2594933036963893 1.243133256057056 0.043238040904889204 0.10253002134545167 1.6814154371554223e-07 6.774324969622175 -0.3318635616755141 VPNCNVVPHFNK(ub)IQDFNDTFYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPNCNVVPHFNKIQDFNDTFYR 22 1 F8W8D4;Q8TBC4-2;Q8TBC4 F8W8D4 UBA3 NEDD8-activating enzyme E1 catalytic subunit 1 76343000.0 36433000.0 23244000.0 16666000.0 True False 35276454.35741597 32525450.415858667 12300674.630717076 1.0 0.9220158603899212 0.3486936217026918 25.072202226863403 -6.931703981490547 0.7326743782668584 1.0081909388511319 0.22571964893204544 0.9968625808558444 0.016265976121180633 0.09176281142205316 0.07341729085192 0.014972162268306097 0.05139839587825794 1.170296802665337e-07 6.931703981490547 -0.7824712899190864 down VPNCNVVPHFNK(ub)IQDFNDTFYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VPNCNVVPHFNKIQDFNDTFYR 22 1 F8W8D4;Q8TBC4-2;Q8TBC4 F8W8D4 UBA3 NEDD8-activating enzyme E1 catalytic subunit 1 279568100.0 97204100.0 99838000.0 82526000.0 True False 147465726.27159753 82021128.86214556 66214699.92756927 1.0 0.5562046920047153 0.4490175554800931 27.135804443853424 -13.999999999999957 0.1995677445489436 3.4629531906749493 0.37910811626197577 0.999486916125935 0.0054027922495746864 12.522369434927018 0.14165244998393883 12.036715235620644 0.0684716943381337 1.0000000000000981e-14 13.999999999999957 -3.0838450744129737 VPNCNVVPHFNK(ub)IQDFNDTFYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPNCNVVPHFNKIQDFNDTFYR 22 1 F8W8D4;Q8TBC4-2;Q8TBC4 F8W8D4 UBA3 NEDD8-activating enzyme E1 catalytic subunit 1 115113000.0 22067000.0 39792000.0 53254000.0 True False 30225766.23825224 38033857.86545272 40676502.00055754 1.0 1.2583256803368956 1.3457558587573328 24.84927557718849 -13.266618135652024 0.15969252827380223 1.2793773273369637e-06 1.4349915394623114 0.9995351875238435 0.0031646953985452466 9.160390968219305 0.12041457330033824 2.920581302574675 0.07833885178282503 5.412300038833798e-14 13.266618135652024 1.434990260084984 VPNCNVVPHFNK(ub)IQDFNDTFYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VPNCNVVPHFNKIQDFNDTFYR 22 1 F8W8D4;Q8TBC4-2;Q8TBC4 F8W8D4 UBA3 NEDD8-activating enzyme E1 catalytic subunit 1 89457000.0 36433000.0 12865000.0 40159000.0 True False 30295653.755563162 12795693.69149745 48556061.22576342 1.0 0.4223607054245459 1.6027401691850638 24.85260750229768 -6.773639593028554 1.5605529699056937 0.6702250384181939 1.6103084237842815 0.7442803702431626 0.2437029478032207 0.26058187505370617 1.2528815438650018 0.12305760929478371 0.2919575131380307 1.6840710375294636e-07 6.773639593028554 0.9400833853660876 VPNCNVVPHFNK(ub)IQDFNDTFYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPNCNVVPHFNKIQDFNDTFYR 22 1 F8W8D4;Q8TBC4-2;Q8TBC4 F8W8D4 UBA3 NEDD8-activating enzyme E1 catalytic subunit 1 234361800.0 97204100.0 56777300.0 80380400.0 True False 125832623.629268 53617593.34374209 65751991.972552076 1.0 0.4261024827846864 0.5225353336530012 26.906930765945873 -10.006119032757036 5.420531786427688 1.0000021545617508 0.47431890821832545 0.9753826334968306 0.03936854651441309 1.025063233660732e-06 1.8793954928852926e-07 0.038118587710730206 0.012706143750811192 9.860092001817556e-11 10.006119032757036 -0.5256832463434253 VPNSVLWLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPNSVLWLLR 10 0 O15294;O15294-3;O15294-2;O15294-4 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 0 4943960.0 766160.0 2591700.0 1586100.0 False True 1004443.1795039935 2205028.4623674746 1421985.5869455289 1.0 2.195274463863994 1.4156953981684888 19.937964523672747 -10.1407057458421 4.76114906862664 0.9999495362209544 1.805484931017839 0.5873601098906894 0.3182618209877843 0.00022057396032166502 3.980820842226471e-05 0.30818049738896347 0.10271856101461764 7.232596787779891e-11 10.1407057458421 0.8055353947968845 VPNSVLWLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPNSVLWLLR 10 0 O15294;O15294-3;O15294-2;O15294-4 O15294 OGT UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit 0 2669060.0 1110300.0 563390.0 995370.0 False True 1075054.134247493 788354.5650400372 734652.7365400722 1.0 0.7333161558342015 0.6833634820206594 20.035977877738006 -13.999999999999998 0.2355420459349165 2.727830579341557 0.6603222694815396 0.9995178415359408 0.003052041763143353 13.470183557385779 0.1536312319947944 10.9190936347366 0.025064821510893648 1.0000000000000041e-14 13.999999999999998 -2.0675083098600173 VPPAINQFTQALDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPPAINQFTQALDR 14 0 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 0 10668700.0 3422300.0 1716000.0 5530400.0 False True 3313660.959772308 2401207.7488217847 4081822.331556319 1.0 0.7246389349943572 1.2318165259238814 21.65999456878237 -6.759250514421337 1.6151576902450873 0.8399065308552373 1.2336095178750985 0.6879478060769859 0.11580597118356437 0.2841808861086192 1.4609420458011446 0.056574485871043696 0.1360654634576117 1.740802435311145e-07 6.759250514421337 0.3937029870198613 VPSEVVK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VPSEVVKQR 9 1 H0YCZ5;H0YF50;H7C430;Q70HW3-3;Q70HW3-2;Q70HW3 H0YCZ5 SLC25A26 S-adenosylmethionine mitochondrial carrier protein 1 4670970.0 496870.0 1586000.0 2588100.0 True False 753788.1160626825 1302965.90852544 2076560.900595472 1.0 1.7285572440851398 2.754833694436743 19.523799524635972 -6.96628047268371 0.3353502015178621 0.8825157568815208 3.6347424515468503 0.9999371588897402 0.005706312100515077 0.07752908483360856 0.013342368918742343 0.014702811109980488 0.08913853396548382 1.0807357735066637e-07 6.96628047268371 2.7522266946653295 VPSEVVK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPSEVVKQR 9 1 H0YCZ5;H0YF50;H7C430;Q70HW3-3;Q70HW3-2;Q70HW3 H0YCZ5 SLC25A26 S-adenosylmethionine mitochondrial carrier protein 1 3581570.0 496870.0 1493900.0 1590800.0 True False 643208.0097719575 1410763.1517563576 1301290.7229863983 1.0 2.19332335779918 2.0231258056748342 19.29492584672842 -10.207638750624236 5.027803631651132 0.9998886913487135 2.1082245815463247 0.9826181062796935 0.06948285973261203 8.959666980888357e-05 1.4119973479209757e-05 0.06728335052061893 0.022425496543769675 6.199565451201055e-11 10.207638750624236 1.1083358901976113 VPSGFYVGSYVHGAMQSPSLHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPSGFYVGSYVHGAMQSPSLHK 22 0 P43897;P43897-2 P43897 TSFM Elongation factor Ts, mitochondrial 0 8459900.0 1955700.0 1870600.0 4633600.0 False True 2678775.140805264 1787950.7067530123 3539239.111987519 1.0 0.6674508358381802 1.321215453314828 21.353142054252082 -6.768429016710829 1.5805258222727852 0.8088764714129759 1.3246715838208332 0.7245011164258817 0.14009655666438137 0.2689737825297805 1.3258141250873048 0.06987855345369826 0.16657687853471775 1.7043978719692955e-07 6.768429016710829 0.5157951124078572 VPSGQNADVQK(ub)TDN ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPSGQNADVQKTDN 14 1 E7EQ69;Q9GZZ1;C9J5D1;A0A087WWJ2;B0AZT5;C9J5J3;A0A0D9SF32;Q9GZZ1-2 E7EQ69;Q9GZZ1-2 NAA50 N-alpha-acetyltransferase 50 1 2969910.0 991230.0 1695500.0 283180.0 True False 1299512.1290849734 1442538.0090072372 253879.25005436948 1.0 1.1100612119895894 0.1953650484456299 20.309538668689562 -6.876835262345322 1.097247269029703 1.0657434378641615 0.13433768571944874 0.9710440560244166 0.06938176247432708 0.13047273824076552 0.289512350343471 0.048838518980947654 0.11721562204831025 1.32789806377985e-07 6.876835262345322 -0.9314057521447128 down VPSGQNADVQK(ub)TDN ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPSGQNADVQKTDN 14 1 E7EQ69;Q9GZZ1;C9J5D1;A0A087WWJ2;B0AZT5;C9J5J3;A0A0D9SF32;Q9GZZ1-2 E7EQ69;Q9GZZ1-2 NAA50 N-alpha-acetyltransferase 50 1 3924230.0 1756700.0 1547800.0 619730.0 True False 1700934.520068964 2165844.6116703707 457404.12149851676 1.0 1.2733262721851026 0.2689134214760786 20.69789617276516 -6.8342032241778385 1.3090196716870306 1.145674935796888 0.23948735775449032 0.9140296795792558 0.124321902033907 0.17567502592183093 0.587221721398893 0.074534880478039 0.17153990997951574 1.464862211518292e-07 6.8342032241778385 -0.9061875780423978 down VPSGQNADVQK(ub)TDN ddPTM_RPMI8226_Bortezomib_8h_R1 1 VPSGQNADVQKTDN 14 1 E7EQ69;Q9GZZ1;C9J5D1;A0A087WWJ2;B0AZT5;C9J5J3;A0A0D9SF32;Q9GZZ1-2 E7EQ69;Q9GZZ1-2 NAA50 N-alpha-acetyltransferase 50 1 5176400.0 2385700.0 1738600.0 1052100.0 True False 3619281.318032362 1428333.2462561983 844151.9738481893 1.0 0.39464554444546956 0.2332374578462213 21.78727181860873 -13.99999999999968 0.18554030776838198 4.196646844404455 0.11209829121544972 0.9994924914493407 0.007435478095117098 12.281479595630735 0.1365857528792958 14.173707493024 0.1150698646453432 1.0000000000007362e-14 13.99999999999968 -4.084548553189006 VPSGQNADVQK(ub)TDN ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPSGQNADVQKTDN 14 1 E7EQ69;Q9GZZ1;C9J5D1;A0A087WWJ2;B0AZT5;C9J5J3;A0A0D9SF32;Q9GZZ1-2 E7EQ69;Q9GZZ1-2 NAA50 N-alpha-acetyltransferase 50 1 2773760.0 991230.0 1174900.0 607630.0 True False 1357714.5179835367 1122989.0331252608 464120.3085326693 1.0 0.8271172019233559 0.3418393943536642 20.372748730212454 -6.952935408196706 0.5256300882420639 1.00790173581799 0.13918916755148011 0.9994119699501374 0.006755845437239151 0.08232799568557962 0.031246512910265693 0.007586692646387537 0.04010839895483549 1.114460272851359e-07 6.952935408196706 -0.8687125682665099 down VPSGQNADVQK(ub)TDN ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPSGQNADVQKTDN 14 1 E7EQ69;Q9GZZ1;C9J5D1;A0A087WWJ2;B0AZT5;C9J5J3;A0A0D9SF32;Q9GZZ1-2 E7EQ69;Q9GZZ1-2 NAA50 N-alpha-acetyltransferase 50 1 5777610.0 2385700.0 2470600.0 921310.0 True False 3088335.679177567 2333108.9381680572 753641.0334388982 1.0 0.7554583376083558 0.24402821186834037 21.55839814070118 -7.0295314016693204 0.46738633442633776 1.0140335001631093 2.037959447101039e-11 0.999703437755891 0.005424089336990971 0.0737501916125797 0.023732159477179278 0.007005959967521722 0.03873765014919332 9.342618139999843e-08 7.0295314016693204 -1.0140335001427296 down VPSK(ub)NQNDPLPGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VPSKNQNDPLPGR 13 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 21478000.0 10720000.0 3495000.0 7263000.0 True False 16263023.736977378 2871289.9434403605 5827464.8665140085 1.0 0.1765532652400847 0.358326038303938 23.955092182681017 -10.518712443408704 9.248401380541672 1.000025924053102 0.26743965222699023 0.9558605755718115 0.07420842385619385 3.9667930687050815e-05 2.064306710792271e-06 0.07185451729654285 0.023950665811944986 3.028918282333924e-11 10.518712443408704 -0.7325862718261118 VPSK(ub)NQNDPLPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPSKNQNDPLPGR 13 1 O75534-2;O75534;O75534-3;O75534-4;E9PLT0 O75534-2 CSDE1 Cold shock domain-containing protein E1 1 19249100.0 10720000.0 4641000.0 3888100.0 True False 13877251.322791433 4382724.270233122 3180505.6952749644 1.0 0.3158207751873106 0.22918844815121503 23.726218504773467 -13.999999999999998 0.2913878044919512 6.941903955169644 0.20590921617793287 0.9996305688399972 0.0066265560279517915 16.048737654260265 0.17121245588448009 57.20921921827762 0.03251505087928214 1.0000000000000041e-14 13.999999999999998 -6.735994738991711 VPSLVGSFIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPSLVGSFIR 10 0 Q5TA02;P78417-3;P78417 Q5TA02 GSTO1 Glutathione S-transferase omega-1 0 8285800.0 1768800.0 3374500.0 3142500.0 False True 2318913.9290835676 2871037.753697978 2817344.244988545 1.0 1.238095867936163 1.2149412747293973 21.145017841921824 -10.022250376351696 4.416019520993082 0.9999891310351381 1.2265185713510962 0.9922243269817289 0.009452823201643569 3264664.62869755 0.19966376985087966 361.7661927100691 0.003235952796165818 9.50056915717175e-11 10.022250376351696 0.22652944031595812 VPSLVGSFIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPSLVGSFIR 10 0 Q5TA02;P78417-3;P78417 Q5TA02 GSTO1 Glutathione S-transferase omega-1 0 7610800.0 2713500.0 1611400.0 3285900.0 False True 2627361.4277948034 2254840.423339991 2425224.215112999 1.0 0.858214785178042 0.9230645580225854 21.325183244946388 -10.129217617950774 4.539482285155748 1.0000121887291897 0.8906396715974826 0.7913086286859099 0.026474808910399376 6182362.209740266 13795073.589986984 450.52661737581076 0.009063032447004814 7.426469162718022e-11 10.129217617950774 -0.10937251713170715 VPSLVGSFIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPSLVGSFIR 10 0 Q5TA02;P78417-3;P78417 Q5TA02 GSTO1 Glutathione S-transferase omega-1 0 8606400.0 1768800.0 1945200.0 4892400.0 False True 2422773.1600226825 1859254.6320837992 3736915.8821408246 1.0 0.7674076396266469 1.5424126136950596 21.208227903444715 -6.82623952326584 1.3445323058866199 0.8753549330514749 1.5617231260357376 0.8981515271616192 0.10362776960440713 0.18550509982543373 0.6571495618268065 0.06053529730734713 0.13935683635491677 1.4919713265690143e-07 6.82623952326584 0.6863681929842627 VPTANVSVVDLTCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPTANVSVVDLTCR 14 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 1363830000.0 314950000.0 569990000.0 478890000.0 False True 412902499.9801383 484949713.8036179 429339056.63725173 1.0 1.1744896527072257 1.0398073556297287 28.62122591265302 -9.979213243985223 4.971348865009043 0.9999990983823884 1.1071485041703046 0.45767063446139944 0.05498381754396651 5.498024213674574e-07 1.1298140773961345e-07 0.05323830142112982 0.01774595080398562 1.0490272167809813e-10 9.979213243985223 0.10714940578791621 VPTANVSVVDLTCR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPTANVSVVDLTCR 14 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 630839000.0 213580000.0 98199000.0 319060000.0 False True 206800019.80778137 137410372.80101997 235488614.40517125 1.0 0.6644601529958343 1.138726266196955 27.6236610829364 -6.716640953388439 1.7713847530086768 0.7951330002733268 1.137852106395805 0.49662702234733347 0.14125764498738158 0.3618856294194507 2.217309785035864 0.0633635014273965 0.15969902842553316 1.9202556278695166e-07 6.716640953388439 0.34271910612247813 VPTANVSVVDLTCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VPTANVSVVDLTCR 14 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 2024460000.0 143650000.0 1569700000.0 311110000.0 False True 217927552.22171676 1289574770.8779213 249618972.13564304 1.0 5.917447141176184 1.145421813767191 27.699273364643133 -6.6391661292571555 2.0471728431729663 4.217744148070725 1.1651337188088442 0.15147875423067447 2.1044660630981236 0.5355147169426574 4.288199382700206 0.8373745710087986 2.33075317540173 2.2952704778026287e-07 6.6391661292571555 -3.0526104292618808 VPTANVSVVDLTCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPTANVSVVDLTCR 14 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 1153180000.0 314950000.0 397630000.0 440600000.0 False True 431395526.20372164 380061391.81342894 336539354.4418375 1.0 0.8810044813351848 0.7801178593653533 28.684435974175912 -6.973038020983706 0.17066747951619962 1.0883382848025949 0.5700805936306145 0.9999974125090643 0.00014444333133943293 0.0753286630582527 0.005327335410167473 0.004225656450392722 0.011662616485784176 1.0640498602519307e-07 6.973038020983706 -0.5182576911719804 VPTANVSVVDLTCR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VPTANVSVVDLTCR 14 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 434540000.0 213580000.0 116220000.0 104740000.0 False True 177601233.19828662 115593899.79213607 126640649.73695722 1.0 0.6508620335033307 0.7130617702162384 27.404066358370677 -10.680137247812748 6.706088455701281 1.0022774625160158 0.6819619018597879 0.9721133097718798 0.02539293618034694 0.0008697559302002164 4.148501948113173e-05 0.024732081676114997 0.008195534911482616 2.0886359658494113e-11 10.680137247812748 -0.3203155606562279 VPTANVSVVDLTCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPTANVSVVDLTCR 14 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 783560000.0 143650000.0 380690000.0 259220000.0 False True 185957756.76483136 359504266.84659505 212044619.82180947 1.0 1.9332577091755125 1.1402838123605055 27.470399686735583 -10.177283706539015 4.238921368672875 0.999838170400653 1.5367707607983114 0.37924446670520107 0.3237302379720463 113534261.95772555 64.05258258778609 193618.61283177545 0.11082147114468627 6.64838702813167e-11 10.177283706539015 0.5369325903976584 VPTISINK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPTISINK 8 0 Q01518;Q01518-2;P40123;E9PDI2;B7Z385;A0A087WZ15;A0A087X0J3;P40123-3;P40123-2 Q01518 CAP1;CAP2 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 2;Adenylyl cyclase-associated protein 0 10809300.0 1873500.0 4195500.0 4740300.0 False True 2456176.642999811 3569547.7539309114 4249819.228168395 1.0 1.4532943972512102 1.7302579764694563 21.227982889322075 -9.397149556914593 0.10615323748791014 3.402569928751214e-23 2.480788062440582 0.9999387979327332 0.002354844185228211 0.8616518122090167 0.04079114757982172 0.5905498540435266 0.34365287319879084 4.0072869591552386e-10 9.397149556914593 2.480788062440582 VPTISINK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPTISINK 8 0 Q01518;Q01518-2;P40123;E9PDI2;B7Z385;A0A087WZ15;A0A087X0J3;P40123-3;P40123-2 Q01518 CAP1;CAP2 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 2;Adenylyl cyclase-associated protein 0 9471400.0 4064400.0 1248800.0 4158200.0 False True 3935377.846740081 1747452.3524059665 3069042.6766739273 1.0 0.4440367406787865 0.7798597228004948 21.908070728931943 -10.367264485177195 6.097360933962019 1.0000538112223198 0.6119482317396531 0.6403287310802306 0.1370991583496644 0.00010030232653919068 1.0408598709791216e-05 0.13276402125994713 0.0442485630889419 4.292749188786785e-11 10.367264485177195 -0.3881055794826668 VPTISINK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPTISINK 8 0 Q01518;Q01518-2;P40123;E9PDI2;B7Z385;A0A087WZ15;A0A087X0J3;P40123-3;P40123-2 Q01518 CAP1;CAP2 Adenylyl cyclase-associated protein 1;Adenylyl cyclase-associated protein 2;Adenylyl cyclase-associated protein 0 14867200.0 1873500.0 6370400.0 6623300.0 False True 2566183.5794337955 6088934.663904294 5059012.9511453165 1.0 2.3727587974231215 1.971415058411971 21.291192950844966 -10.238363399729508 5.2864619155811345 0.999889696484174 2.1720869279177357 0.9191703649944624 0.16384789534037988 0.00021303209200251811 3.0691597552102094e-05 0.15865968062951358 0.05288168083026753 5.776125227757845e-11 10.238363399729508 1.1721972314335618 VPTTEKPTVTVNFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPTTEKPTVTVNFR 14 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 98669000.0 20423000.0 30656000.0 47590000.0 False True 26774750.776613362 26082244.296152096 42665843.31551466 1.0 0.9741358384158653 1.5935103811603546 24.67436981042825 -6.8971563332624575 0.9790845417390324 0.9722001260303135 1.654893299853898 0.9850967656428696 0.03492365069964363 0.11352936607943037 0.1894678046101249 0.026889248045927242 0.06901354308423825 1.267195630525398e-07 6.8971563332624575 0.6826931738235846 VPTTEKPTVTVNFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPTTEKPTVTVNFR 14 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 37222300.0 9324500.0 5260800.0 22637000.0 False True 9028498.851473248 7361464.874709573 16707690.604556734 1.0 0.8153586765432603 1.8505502276084818 23.106054703257524 -6.860784186822913 1.1816461792077422 0.8995934541086602 1.9014640130112344 0.9545942454159718 0.09606359008756529 0.14600273289884083 0.38691271336397937 0.06338299758347263 0.1480998145940076 1.377894013193048e-07 6.860784186822913 1.0018705589025743 VPTTEKPTVTVNFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VPTTEKPTVTVNFR 14 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 70500000.0 11653000.0 40331000.0 18516000.0 False True 17678452.948413957 33133617.94245874 14856304.484148892 1.0 1.8742374142773257 0.8403622493155852 24.075488693391854 -6.682579009184168 1.8925410643878724 1.5518597856980922 0.8442013530475264 0.3359722383244199 0.370316764491943 0.4328635914498803 2.999660391557553 0.15687476038671846 0.4124123634651342 2.0769258456983734e-07 6.682579009184168 -0.7076584326505658 VPTTEKPTVTVNFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPTTEKPTVTVNFR 14 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 66155000.0 20423000.0 19949000.0 25783000.0 False True 27973935.01082274 19067587.2174788 19693586.4175531 1.0 0.681619772481126 0.7039977182307 24.73757987195114 -10.622554029794845 6.489651039227156 1.0010912297935786 0.6928087453559131 0.9960357675798336 0.009135758096356642 0.00014471329226803172 8.416691076830082e-06 0.008874720486622602 0.0029485532468473993 2.384767092427508e-11 10.622554029794845 -0.3082824844376655 VPTTEKPTVTVNFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VPTTEKPTVTVNFR 14 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 27489400.0 9324500.0 6451900.0 11713000.0 False True 7753734.895390124 6417142.334098116 14162134.14520699 1.0 0.8276195176486287 1.8264919211549122 22.8864599786918 -6.862422268813416 1.1735373230358224 0.9058133834338471 1.8771249105377925 0.9565115530679278 0.09091458923780633 0.14432149282306714 0.3763271296669181 0.06036439721371773 0.14130546328461646 1.3727066297214416e-07 6.862422268813416 0.9713115271039454 VPTTEKPTVTVNFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPTTEKPTVTVNFR 14 1 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 0 41563000.0 11653000.0 19630000.0 10280000.0 False True 15085038.214970969 18537573.243843198 8409145.481707416 1.0 1.2288714804478122 0.5574493986605787 23.846615015484304 -6.814715594841721 1.3946003576453243 1.1240577159854945 0.5443906273087747 0.8717851922813873 0.0997927750971542 0.20044217487244745 0.7673936710618025 0.05625051678942699 0.12986490716139965 1.5320904488297404e-07 6.814715594841721 -0.5796670886767198 VPTYK(ub)DYVDLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPTYKDYVDLFR 12 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 3219970.0 683600.0 895970.0 1640400.0 True False 936345.3935953778 856383.0828234222 1252971.3050984824 1.0 0.9146016936496943 1.338150765378708 19.836681275304628 -6.854257430216065 1.2145152501644814 0.9542077991081802 1.356511024592168 0.9462532759746282 0.04239957709825427 0.15283976675705388 0.43172163783171735 0.027285920993088002 0.0633319580318528 1.3987579560498722e-07 6.854257430216065 0.4023032254839879 VPVGDQPK(ub)DIELQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPVGDQPKDIELQIR 15 1 O00429-9;O00429-4;O00429-2;O00429-8;O00429;O00429-6;O00429-3;O00429-5;F8W1W3;F8VZ52;B4DDQ3;F8VUJ9 O00429-9 DNM1L Dynamin-1-like protein 1 16590500.0 3980700.0 6599000.0 6010800.0 True False 5153094.6213279795 6231759.849012799 4916896.07601625 1.0 1.2093237766720537 0.9541637476761761 22.297007652881938 -6.688666782763245 1.870899840224639 1.131393023906252 0.9550529272831778 0.3643324300320042 0.0885527999173645 0.419526008782224 2.8459555737984976 0.037877314186411645 0.09881045428805056 2.048015396483536e-07 6.688666782763245 -0.17634009662307415 VPVITSSK(ub)EEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPVITSSKEEQK 12 1 Q9H3F6;F5GWA4;Q9H3F6-2 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 12342300.0 4196300.0 4269200.0 3876800.0 True False 5501389.937027012 3632252.0012112646 3475665.9248915175 1.0 0.6602426010133283 0.6317795983699696 22.391364733764895 -13.999999999999998 0.35126720606244427 5.211057959130606 0.6279129066797263 0.9997571153512711 0.0026069502132040597 20.786770526202062 0.19088036696121274 65.3547044813582 0.008455784496842159 1.0000000000000041e-14 13.999999999999998 -4.58314505245088 VPVITSSK(ub)EEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPVITSSKEEQK 12 1 Q9H3F6;F5GWA4;Q9H3F6-2 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 13564200.0 4377000.0 4998600.0 4188600.0 True False 4238054.530848669 6994567.047354634 3091480.0046934765 1.0 1.6504193130223774 0.7294573446827285 22.01497072024304 -6.716968936441156 1.770373977850569 1.396983948186533 0.7311453283715884 0.49812658505236884 0.2738051651014342 0.36123013429033235 2.2109876503766954 0.12288590084161469 0.3095770519795172 1.91880598121415e-07 6.716968936441156 -0.6658386198149445 VPVITSSK(ub)EEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VPVITSSKEEQK 12 1 Q9H3F6;F5GWA4;Q9H3F6-2 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 49215000.0 10097000.0 10582000.0 28536000.0 True False 15317887.189576568 8693559.422456624 22895847.092226867 1.0 0.567542985195267 1.4947131290930846 23.868713982928256 -6.779861471879203 1.5362820539265607 0.7550881054634505 1.5020421720861397 0.7669373567170338 0.18287159287739044 0.250792375281597 1.1691100207690026 0.09375302892463795 0.22125528025591196 1.660116354932065e-07 6.779861471879203 0.7469540666226892 VPVITSSK(ub)EEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VPVITSSKEEQK 12 1 Q9H3F6;F5GWA4;Q9H3F6-2 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 10677300.0 4196300.0 3245400.0 3235600.0 True False 5747785.510743547 3102007.4968973678 2471417.9192737397 1.0 0.5396874137177198 0.4299774086305512 22.454574795287787 -13.999999999999853 0.2014475717457087 3.5730229109830423 0.3597344106306759 0.9994870488328708 0.005592979756962584 12.559908173192651 0.14231034512392285 12.741236447481581 0.06911111896133516 1.0000000000003395e-14 13.999999999999853 -3.213288500352366 VPVITSSK(ub)EEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VPVITSSKEEQK 12 1 Q9H3F6;F5GWA4;Q9H3F6-2 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 15495400.0 4377000.0 7079500.0 4038900.0 True False 3639669.433977433 7041361.3283292735 4883415.316236354 1.0 1.9346156171755602 1.3417194623907795 21.795375995677315 -10.091943720068373 4.3849396609436795 0.9999378008728397 1.638167539769742 0.6070300714398487 0.242048841801456 56117505.98071024 5.438118844615935 37708.43507624622 0.08285975664240704 8.092007561691824e-11 10.091943720068373 0.6382297388969023 VPVITSSK(ub)EEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VPVITSSKEEQK 12 1 Q9H3F6;F5GWA4;Q9H3F6-2 Q9H3F6 KCTD10 BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 1 46303000.0 10097000.0 11123000.0 25083000.0 True False 13070765.541625494 10503995.272097183 20518151.37331395 1.0 0.8036251005073798 1.5697742651699564 23.639840305020705 -6.838723049408315 1.288484689758784 0.8955142045720751 1.5943159988736777 0.9222064749842347 0.09062661923375233 0.17029802188743381 0.5497800616727953 0.05516650539350732 0.12704068705589877 1.4496960333380803e-07 6.838723049408315 0.6988017943016026 VPVQPTK(ub)TTNVNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VPVQPTKTTNVNK 13 1 O95067;H1UBN3 O95067 CCNB2;CCNB2V G2/mitotic-specific cyclin-B2 1 2372560.0 359900.0 1049700.0 962960.0 True False 299272.79627335543 1044045.0577508642 1164310.4837760192 1.0 3.488606618281585 3.8904654825777727 18.19110161907563 -9.956533824362634 0.4418508326908777 1.4779132606908376e-21 3.9084091788024664 0.9989639595654588 0.04114956272590538 1.26411427718498 0.19819937789023226 1.7990041082771457 0.09176978276141584 1.1052643842015564e-10 9.956533824362634 3.9084091788024664 VPYETLNK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VPYETLNKR 9 1 E7ESC7;Q7L5Y9;Q7L5Y9-3;Q7L5Y9-2;D6REW7;D6RIB6;Q7L5Y9-4;D6RDW4;Q7L5Y9-5;D6RE80;D6RA86 E7ESC7 MAEA Macrophage erythroblast attacher 1 9154400.0 2123600.0 1717100.0 5313700.0 True False 2056187.4803998694 2402746.9845582084 3921882.562416975 1.0 1.1685447010361834 1.9073565031405995 20.97154038284036 -6.942778283036123 0.6331975814402516 0.9919375304567043 2.1239998313497104 0.9985055394743738 0.015233650830176321 0.08652187240027749 0.04900879931070373 0.015161828201495487 0.06285125135415684 1.1408320589823588e-07 6.942778283036123 1.132062300893006 VPYETLNK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VPYETLNKR 9 1 E7ESC7;Q7L5Y9;Q7L5Y9-3;Q7L5Y9-2;D6REW7;D6RIB6;Q7L5Y9-4;D6RDW4;Q7L5Y9-5;D6RE80;D6RA86 E7ESC7 MAEA Macrophage erythroblast attacher 1 7242800.0 2123600.0 2489400.0 2629800.0 True False 1765867.4914312253 2475989.1080927867 3179679.0211786306 1.0 1.402137544355614 1.8006328541681909 20.751945658274636 -6.971237465486571 0.22668966319967906 0.8310713592025102 2.38304030988535 0.9999904915798159 0.0010078742219014984 0.07590316355909295 0.007577484039744572 0.010493683809637276 0.039837390257075125 1.0684704963765938e-07 6.971237465486571 1.55196895068284 VPYVIISAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VPYVIISAAK 10 0 P28340;M0R2B7;A0A087WYJ2;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 6403300.0 1550200.0 1863300.0 2989800.0 False True 2032327.2121581547 1585302.903086513 2680444.176186711 1.0 0.7800431414796928 1.3189038458724924 20.95470126934447 -6.795880474140206 1.4726324593281213 0.8779960769857226 1.325609891105641 0.8198350411976303 0.09389943411247931 0.22670403595534888 0.9709842176344404 0.050171924346806465 0.11698841634049889 1.5999983171017482e-07 6.795880474140206 0.4476138141199185 VQAGAYPTEK(ub)GLSFLEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQAGAYPTEKGLSFLEVK 18 1 G3V4G1;H0YJ17;Q8NEJ9-2;Q8NEJ9 G3V4G1 NGDN Neuroguidin 1 18565500.0 5592100.0 4118600.0 8854800.0 True False 5414581.846460775 5763178.458215262 6535462.241694077 1.0 1.0643810771800128 1.2070114418837279 22.36841849601629 -6.9579960879386284 0.4628116886923881 0.9959572792608942 1.2812121331670556 0.9996884996053803 0.0015266806743248606 0.08042488107821055 0.023836184116026022 0.0019465068698191613 0.011779259605380926 1.101549232091598e-07 6.9579960879386284 0.28525485390616145 VQAHAAAALINFTEDCPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQAHAAAALINFTEDCPK 18 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 28052100.0 3466900.0 16066000.0 8519200.0 False True 5259540.764340196 13198896.775769057 6835376.385901999 1.0 2.50951506360743 1.2996146797161463 22.326505405736658 -6.5910040141554225 2.2247904688548448 2.0210079556424807 1.3031490326309592 0.0 0.6539513875975264 0.6665989122610229 6.221677021252499 0.2452264713121555 0.7288302731609577 2.5644603332694477e-07 6.5910040141554225 -0.7178589230115215 VQAHAAAALINFTEDCPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQAHAAAALINFTEDCPK 18 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 7360400.0 3309600.0 0.0 4050800.0 False True 4533248.558577036 0.0 3094084.4688447476 1.0 0.0 0.6825313963847518 22.112113835863624 -10.445966854073761 8.129069541596392 1.0000206507725187 0.34126570125667494 0.5539653634613336 0.2786422757619882 0.00010428928081023713 7.107650680228704e-06 0.26980264160010003 0.0899314077979596 3.581237685368177e-11 10.445966854073761 -0.6587549495158438 VQAINVSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQAINVSSR 9 0 Q96C19 Q96C19 EFHD2 EF-hand domain-containing protein D2 0 3686530.0 715630.0 1573300.0 1397600.0 False True 938197.8601707778 1338569.7726753666 1252989.758725852 1.0 1.4267457105814654 1.3355282631936225 19.839532684794765 -10.04813728747118 4.741370415639656 0.9999904647649552 1.3811369868949206 0.9588103932873028 0.03723936700768383 4.6032173791119895e-06 9.241761874633894e-07 0.036057968278811275 0.012018954012905871 8.950817710775342e-11 10.04813728747118 0.38114652212996536 VQAINVSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQAINVSSR 9 0 Q96C19 Q96C19 EFHD2 EF-hand domain-containing protein D2 0 3605130.0 715630.0 1349600.0 1539900.0 False True 980217.7501735813 1289970.2094696166 1176207.3352360106 1.0 1.3160037239084714 1.199944945934434 19.902742746317656 -10.130459755703903 4.308054463503959 0.9999566562168068 1.2579743349030652 0.868208265984915 0.04738079780178023 33080594.99741852 1.492945655090405 15192.011226412616 0.016219707327675827 7.405258857812889e-11 10.130459755703903 0.25801767868625836 VQAMQISSEKEEDDNEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQAMQISSEKEEDDNEK 17 1 Q9UKY7;Q9UKY7-2;H0Y8K3 Q9UKY7 CDV3 Protein CDV3 homolog 0 5449210.0 2022000.0 435810.0 2991400.0 False True 1957812.7167868398 609831.2057191266 2207862.599923618 1.0 0.31148597641146236 1.1277190003889443 20.900811333507004 -6.6830483053108445 1.891239136988691 0.5655927053842308 1.1246878173063073 0.3382928058910726 0.29161058047177535 0.43164410528442165 2.9875877241850564 0.12361245316050976 0.3247301563603103 2.0746827436995205e-07 6.6830483053108445 0.5590951119220765 VQAMQISSEKEEDDNEKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQAMQISSEKEEDDNEKR 18 2 Q9UKY7;Q9UKY7-2;H0Y8K3 Q9UKY7 CDV3 Protein CDV3 homolog 0 11862100.0 2283700.0 1135500.0 8442900.0 False True 2211205.1935341777 1588911.0715542727 6231451.208429202 1.0 0.7185724220440664 2.8181243543795453 21.076401478674743 -6.873106055738827 1.1175910041688972 0.837431127495401 2.948535373346705 0.9676832476894671 0.16727923708278805 0.1339087065062775 0.31071958330879784 0.11593338424029495 0.27604495174655846 1.3393495751552963e-07 6.873106055738827 2.111104245851304 up VQANLGAPDINIEGLDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQANLGAPDINIEGLDAK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 19680300.0 2710500.0 9822200.0 7147600.0 False True 3553491.7485193373 8356766.046635724 6408034.916620558 1.0 2.351705488022536 1.8033065418797292 21.760805918578715 -9.9495962484257 5.525975768580514 0.9999983099074211 2.0775060149532374 0.83732866229884 0.22388293226239686 4.6617269529830445e-06 8.861726078404741e-07 0.21677405610045802 0.0722579056782867 1.1230620488674844e-10 9.9495962484257 1.0775077050458162 VQANLGAPDINIEGLDAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQANLGAPDINIEGLDAK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 20964000.0 6598600.0 5183300.0 9182100.0 False True 6389131.054891023 7253018.720552415 6777032.552904545 1.0 1.1352120747312056 1.0607127158107947 22.607188302054457 -10.090959604573879 4.403821855428 0.9999904688222188 1.0979623952766022 0.6974677431337466 0.030414235944876886 2.903750047709641e-06 5.993804122961267e-07 0.02945137983869291 0.009816152438351362 8.11036492017614e-11 10.090959604573879 0.09797192645438346 VQANLGAPDINIEGLDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQANLGAPDINIEGLDAK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 54802100.0 4523500.0 45119000.0 5159600.0 False True 6862480.212147126 37067161.93364396 4139802.7984669846 1.0 5.4014235069169585 0.6032516918794476 22.710298653459734 -6.665472138332018 1.953626662908611 3.820254441592958 0.6230494138397817 0.25912829927645153 1.8715965316776622 0.471557317675773 3.4653385910623644 0.772503312152599 2.076045537727293 2.1603686263184454e-07 6.665472138332018 -3.197205027753176 VQANLGAPDINIEGLDAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQANLGAPDINIEGLDAK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 23380500.0 2710500.0 9157000.0 11513000.0 False True 3712645.0985082965 8752413.461850388 8793866.51767788 1.0 2.3574603091922306 2.3686256790909446 21.824015980101606 -10.836095768058485 0.8266338214343092 2.0238335705050758e-16 2.366132123096271 0.999990792660267 0.001949752140595023 2.7031206531450667 0.44672627463893494 5.3142841192817425 0.0015854012044430675 1.4584926066219446e-11 10.836095768058485 2.366132123096271 VQANLGAPDINIEGLDAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQANLGAPDINIEGLDAK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 13189700.0 6598600.0 4708800.0 1882300.0 False True 5487028.267544773 4683432.759776377 2275880.22722813 1.0 0.8535463153121364 0.4147746496386278 22.387593577488733 -6.951480718657291 0.5423429417245467 1.0063621590774636 0.24161475239830524 0.999312427407366 0.006520096687345585 0.08289652937824052 0.03354321632727249 0.007148512284400342 0.03635038011949109 1.1181994681082782e-07 6.951480718657291 -0.7647474066791584 down VQANLGAPDINIEGLDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQANLGAPDINIEGLDAK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 16379900.0 4523500.0 6694400.0 5162000.0 False True 5855759.921515584 6321850.7551494595 4222568.966592779 1.0 1.0795952771084991 0.7210966677574953 22.481424975552184 -6.848459037004279 1.2425256617884912 1.042424967277837 0.7071873724740609 0.938030320440685 0.03826437785458992 0.15916008630733788 0.47363314579945986 0.024107064935927822 0.05573235004230802 1.4175584103570712e-07 6.848459037004279 -0.335237594803776 VQANLGAPDINIEGLDAK(ub)VK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQANLGAPDINIEGLDAKVK 20 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 22678800.0 7075300.0 6523900.0 9079600.0 True False 6850698.474323418 9128927.291689051 6701380.3778386405 1.0 1.3325542389443192 0.9782039602174252 22.707819657261677 -6.660510721057238 1.9713217079890135 1.2139774333402202 0.9796886788726782 0.2376365301815807 0.1415780971639113 0.4832613081063327 3.6108122959985427 0.05801622213554663 0.15693079892820067 2.1851903750575369e-07 6.660510721057238 -0.23428875446754205 VQASLAANTFTITGHAETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQASLAANTFTITGHAETK 19 0 P20290;H0Y9Y1;P20290-2;D6RDG3 P20290;P20290-2 BTF3 Transcription factor BTF3 0 62552000.0 21367000.0 24334000.0 16851000.0 False True 28012343.918322366 20703462.053189076 15107420.16620587 1.0 0.7390835309446318 0.5393129618233903 24.739559369432627 -7.110994562944016 0.13425995062208176 1.300491181715005 9.71549203196868e-09 0.9999988230543189 0.00020455356935958788 0.07800614093654838 0.004702508669894453 0.014550945032089811 0.02980773243124044 7.744714935704504e-08 7.110994562944016 -1.3004911719995131 VQASLAANTFTITGHAETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQASLAANTFTITGHAETK 19 0 P20290;H0Y9Y1;P20290-2;D6RDG3 P20290;P20290-2 BTF3 Transcription factor BTF3 0 98467000.0 25343000.0 24152000.0 48972000.0 False True 24538500.337056868 33796019.551016174 36144764.07149148 1.0 1.3772650767895154 1.472981786784557 24.5485437460403 -12.258193956008203 0.2207102657274953 3.972242042256296e-08 1.5281986248603487 0.9993933297600641 0.005029069149756371 5.910281510331994 0.13668121005728104 2.7078244995022684 0.05257892876209186 5.51830936426891e-13 12.258193956008203 1.5281985851379283 VQASLAANTFTITGHAETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQASLAANTFTITGHAETK 19 0 P20290;H0Y9Y1;P20290-2;D6RDG3 P20290;P20290-2 BTF3 Transcription factor BTF3 0 417612000.0 88272000.0 192990000.0 136350000.0 False True 133915077.54761827 158549426.66224763 109400362.73567194 1.0 1.1839550076493048 0.8169383518205464 26.996743162468977 -6.770446220899852 1.5728981234259103 1.1054521339603607 0.8148466172258536 0.7322113640302524 0.0775365812324204 0.2657080077147737 1.2974170524648743 0.03885563102624746 0.09244895969522621 1.6964996684264044e-07 6.770446220899852 -0.2906055167345071 VQASLAANTFTITGHAETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQASLAANTFTITGHAETK 19 0 P20290;H0Y9Y1;P20290-2;D6RDG3 P20290;P20290-2 BTF3 Transcription factor BTF3 0 82894000.0 21367000.0 25938000.0 35589000.0 False True 29266957.321463518 24791973.394504223 27183611.178462457 1.0 0.8470977396861998 0.9288157590104799 24.802769430955518 -10.13094182222573 4.3553977226849465 1.0000166390352 0.8879567493406838 0.7148185115243655 0.03336124172827614 46586900.00249723 0.8342599331595614 8586.027428381405 0.01142044039464415 7.397043586816842e-11 10.13094182222573 -0.1120598896945163 VQASLAANTFTITGHAETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQASLAANTFTITGHAETK 19 0 P20290;H0Y9Y1;P20290-2;D6RDG3 P20290;P20290-2 BTF3 Transcription factor BTF3 0 59125000.0 25343000.0 19417000.0 14365000.0 False True 21073827.385261636 19312396.76702725 17368655.083744425 1.0 0.9164161978727094 0.8241813300554749 24.328949021474575 -6.969857464686763 0.2615708231785333 1.0254034058794468 0.712452036771573 0.999981242288409 0.0003109421630082639 0.07634901745837906 0.009195633571353152 0.001906066678158381 0.008682166210603817 1.0718710352544027e-07 6.969857464686763 -0.3129513691078738 VQASLAANTFTITGHAETK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQASLAANTFTITGHAETK 19 0 P20290;H0Y9Y1;P20290-2;D6RDG3 P20290;P20290-2 BTF3 Transcription factor BTF3 0 316114000.0 88272000.0 143390000.0 84452000.0 False True 114269844.1012543 135410220.45005974 69082602.55069612 1.0 1.1850039834663026 0.604556723552385 26.767869484561427 -6.820979816726109 1.3677673111717692 1.0996160866496207 0.5916301222957178 0.8865972388099577 0.08152867535656981 0.19220839574554885 0.7063105618529923 0.04683936284921917 0.10792265870525113 1.510150334815413e-07 6.820979816726109 -0.507985964353903 VQAVCADVEK(ub)SER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQAVCADVEKSER 13 1 Q15018 Q15018 FAM175B BRISC complex subunit Abro1 1 2473030.0 822680.0 1106300.0 544050.0 True False 1078541.446844453 941244.3523236244 487756.92489610723 1.0 0.8727011419704582 0.45223753461043525 20.040650187647312 -6.949270517726262 0.5667999670606836 1.0053157105959274 0.2992925220532336 0.9991427543106934 0.006852855945445473 0.08378008650211599 0.03718554747985069 0.007286963655254514 0.035005853714342436 1.1239046868039652e-07 6.949270517726262 -0.7060231885426937 down VQAVCADVEK(ub)SER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQAVCADVEKSER 13 1 Q15018 Q15018 FAM175B BRISC complex subunit Abro1 1 13023700.0 2591600.0 4000300.0 6431800.0 True False 3931646.671338673 3286415.210513447 5160551.910841914 1.0 0.8358877298082501 1.3125675683071527 21.90670224491628 -6.813757799185621 1.3986872324686797 0.9109484210207655 1.321642328778232 0.8694061201840829 0.07145325439305836 0.20172414014597034 0.7770527472351183 0.04016093200468327 0.09275219692329882 1.535473058941221e-07 6.813757799185621 0.4106939077574665 VQAVCADVEK(ub)SER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQAVCADVEKSER 13 1 Q15018 Q15018 FAM175B BRISC complex subunit Abro1 1 10481700.0 2591600.0 4149100.0 3741000.0 True False 3354877.2880733474 3918198.937647977 3060176.3859015033 1.0 1.1679112531409863 0.9121574719828021 21.677828567008728 -6.729595271037381 1.7245911782724204 1.1010946398747663 0.9123182585035288 0.5573992785125915 0.07058841904222991 0.33701768182003944 1.96351586834347 0.032437407812036245 0.0805316706243795 1.8638232671068735e-07 6.729595271037381 -0.18877638137123753 VQAVVAVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQAVVAVAR 9 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 10435600.0 3902600.0 2755200.0 3777800.0 False True 5116346.3928321535 2344134.899685484 3386909.49521646 1.0 0.45816579248221856 0.6619781451782502 22.286682511867376 -10.29641242951876 6.782016555281129 1.0000074411248645 0.5600719688302357 0.8613448345238639 0.08320604456357285 9.361907966833464e-06 9.712071154160202e-07 0.08056526830217697 0.02685463540820915 5.053445315732701e-11 10.29641242951876 -0.4399354722946288 VQAVVAVAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQAVVAVAR 9 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 6032030.0 1582700.0 939130.0 3510200.0 False True 1532458.0548261805 1314129.5064982527 2590773.316257236 1.0 0.8575304898947517 1.6905998230085948 20.547416155525763 -6.862846362451728 1.1711922314091578 0.9220303261315137 1.7332053349436758 0.9570117659770907 0.07543126519671214 0.14390280291534688 0.373463789224549 0.05016989198129217 0.1175189670093121 1.3713668199275427e-07 6.862846362451728 0.8111750088121621 VQAVVAVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQAVVAVAR 9 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 17207800.0 2399300.0 9159200.0 5649300.0 False True 3639913.5123255425 7524669.198843777 4532713.378823845 1.0 2.0672659318315127 1.245280516549387 21.795472740401603 -10.179690225861881 4.601610370291114 0.9999123288379717 1.6562732241045495 0.4594371321027513 0.3355741408530467 235431644.67836958 57.72524585883084 274988.21743734414 0.1148759541187575 6.61164876407982e-11 10.179690225861881 0.6563608952665778 VQAVVAVAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQAVVAVAR 9 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 8237700.0 3902600.0 1718300.0 2616800.0 False True 5345496.683799471 1642379.8243417602 1998765.7346877023 1.0 0.3072455042988428 0.3739158123033424 22.349892573390267 -10.168206686534642 5.318615382545345 1.0000248412227628 0.34058065831919576 0.9923917289019052 0.027218039268327297 8.017645841171075e-06 1.2538914553813522e-06 0.026354743465801873 0.008784584400106711 6.788804674576034e-11 10.168206686534642 -0.6594441829035671 VQAVVAVAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQAVVAVAR 9 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 4727000.0 1582700.0 1937600.0 1206700.0 False True 1316085.1754983063 1927161.7642165138 1459015.390849591 1.0 1.4643138606031612 1.1086025570473943 20.32782143096004 -10.036090564837902 6.2813477725205455 0.9999997474130977 1.286458208825283 0.4637209856090717 0.1452185315753331 5.135693556806781e-07 7.888726070607947e-08 0.14060736429884788 0.046869079529327305 9.202576474284638e-11 10.036090564837902 0.28645846141218523 VQAVVAVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQAVVAVAR 9 0 Q01082;A0A087WUZ3;Q01082-3;Q01082-2;F8W6C1 Q01082 SPTBN1 Spectrin beta chain, non-erythrocytic 1 0 11167000.0 2399300.0 6025800.0 2741900.0 False True 3105941.1472736457 5690458.932896094 2242902.334269806 1.0 1.8321206562111148 0.7221329149261556 21.566599062494053 -6.706036723877861 1.8089984419379055 1.5136073516648552 0.7249917542634098 0.4464664649466964 0.3508738825731303 0.38307043920457473 2.441024399249602 0.15448787777679737 0.39441876551356764 1.967719892565409e-07 6.706036723877861 -0.7886155974014454 VQDIK(ub)NNLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQDIKNNLK 9 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;A0A590UJQ9;S4R3E3;A0A590UJ22;Q5JWE9;A0A590UJY8;S4R3V9;A0A590UJB7;A0A590UJC9;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;A0A590UK28;A0A590UKA1;A0A590UJA5;A0A590UKA9;P63092-3;A0A590UJF0;A0A590UJG5;H0Y7F4;A0A590UKA4 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 103347200.0 2418200.0 79631000.0 21298000.0 True False 3668586.194100623 65420225.890157305 17088440.964754988 1.0 17.83254431785144 4.658045377871877 21.806792751264855 -9.950497764845089 10.32564535455773 1.0000001563608696 11.24529461350718 0.4463950728955767 5.378466669964636 0.0 0.0 5.2076774946235975 1.735892653408726 1.120733194125791e-10 9.950497764845089 10.245294457146311 VQDIK(ub)NNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQDIKNNLK 9 1 P63092;P63092-4;Q5JWF2;A0A590UJ58;B0AZR9;A0A590UJI6;A0A590UJQ2;A0A590UKB4;A0A590UJR6;A0A590UJQ9;S4R3E3;A0A590UJ22;Q5JWE9;A0A590UJY8;S4R3V9;A0A590UJB7;A0A590UJC9;P63092-2;Q5JWF2-2;A0A590UJB0;A0A590UJS2;A0A590UJJ0;A0A590UK28;A0A590UKA1;A0A590UJA5;A0A590UKA9;P63092-3;A0A590UJF0;A0A590UJG5;H0Y7F4;A0A590UKA4 P63092;P63092-2;P63092-3 GNAS Guanine nucleotide-binding protein G(s) subunit alpha isoforms short;Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas 1 84014900.0 1065400.0 1124500.0 81825000.0 True False 1459307.1713524207 1074815.8717757736 62499620.23877306 1.0 0.7365247652279282 42.8282828082392 20.476852159189637 -6.90200089753898 0.9494831985907265 1.3674557452533895e-18 47.41430964630541 0.9891657828296092 2.058897013323354 0.10520340994230439 0.1623572483341028 1.6536593356672988 4.342700607328965 1.2531385851275067e-07 6.90200089753898 47.41430964630541 up VQDIK(ub)YEPQLLADDDAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQDIKYEPQLLADDDAR 17 1 A0A1W2PQS0;X6R6F3;A0A1W2PQP6;X6R6S3;Q9BWL3-5;Q9BWL3-3;Q9BWL3-4;Q9BWL3-2;Q9BWL3 A0A1W2PQS0 C1orf43 Uncharacterized protein C1orf43 1 9749100.0 2549800.0 2343600.0 4855700.0 True False 3342812.492298324 1993944.015281249 4353278.743163363 1.0 0.5964869462092768 1.3022802664502133 21.672631001749366 -6.751639124074078 1.6436571528022974 0.7631951412259819 1.3038689711323797 0.6560038400488779 0.16957534965194104 0.2972150384722865 1.5802889774246698 0.08148016791225672 0.19748202171933138 1.7715804372558738e-07 6.751639124074078 0.5406738299063978 VQDIK(ub)YEPQLLADDDAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQDIKYEPQLLADDDAR 17 1 A0A1W2PQS0;X6R6F3;A0A1W2PQP6;X6R6S3;Q9BWL3-5;Q9BWL3-3;Q9BWL3-4;Q9BWL3-2;Q9BWL3 A0A1W2PQS0 C1orf43 Uncharacterized protein C1orf43 1 13322900.0 2549800.0 1285900.0 9487200.0 True False 3492529.965754088 1229084.686097347 7246518.755017256 1.0 0.3519181504952298 2.0748622992709604 21.735841063272257 -6.804816418573289 1.4362529397473445 0.6445803817372826 2.101548845721746 0.8458511165211878 0.2789729871375404 0.21395345928330414 0.8707701402614647 0.1527739258251183 0.354292096054767 1.5674134943590905e-07 6.804816418573289 1.4569684639844636 up VQDIK(ub)YEPQLLADDDAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQDIKYEPQLLADDDAR 17 1 A0A1W2PQS0;X6R6F3;A0A1W2PQP6;X6R6S3;Q9BWL3-5;Q9BWL3-3;Q9BWL3-4;Q9BWL3-2;Q9BWL3 A0A1W2PQS0 C1orf43 Uncharacterized protein C1orf43 1 12286500.0 2046800.0 3658100.0 6581600.0 True False 1702004.8886143519 3638393.089223999 7957782.130119886 1.0 2.1377101285449966 4.67553423809407 20.69880375016095 -6.957855464633893 0.4646713253333784 0.9293786350075107 5.986975804395049 0.9996822082344796 0.027388811350816018 0.08047626770674426 0.02403053541955123 0.03474841354734615 0.20955154609000062 1.1019059683181946e-07 6.957855464633893 5.057597169387539 VQDLFCSVGLNVNNPHFLIMQGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQDLFCSVGLNVNNPHFLIMQGR 23 0 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 0 14477800.0 7520000.0 2963900.0 3993900.0 False True 7281281.7162398845 4147400.72653431 2947777.775568279 1.0 0.56959761868355 0.4048432529390631 22.79576099816899 -13.999999999999316 0.13303805544165967 3.046937576565567 0.18277724011247737 0.9996320860156986 0.004812719406602451 11.933246693604616 0.11371634877850591 6.3709542065426366 0.19774118925562353 1.0000000000015747e-14 13.999999999999316 -2.86416033645309 VQDLFCSVGLNVNNPHFLIMQGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQDLFCSVGLNVNNPHFLIMQGR 23 0 O95347;O95347-2 O95347 SMC2 Structural maintenance of chromosomes protein 2 0 82117000.0 22375000.0 28720000.0 31022000.0 False True 33944510.83161096 23594691.609615818 24890488.10257437 1.0 0.6950959383878693 0.73326990116455 25.01667495926223 -10.378968640667301 8.825230921026527 1.0000009448068488 0.7141829198847333 0.9867977603229602 0.015584455043811047 2.8971760829373894e-07 2.038281449493017e-08 0.015089633622851772 0.005029861237033194 4.1786053823548645e-11 10.378968640667301 -0.2858180249221155 VQDLQK(ub)LTSHQSQNLQQPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQDLQKLTSHQSQNLQQPR 19 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 17410600.0 4974500.0 5681700.0 6754400.0 True False 6521617.673126524 4834012.507093135 6055519.480779827 1.0 0.7412290553327798 0.9285302794937922 22.63679843554822 -9.81133483488516 5.48318365661806 1.0000000501338897 0.8348796677114948 0.5088977527832206 0.07646540457340786 4.6889862321212305e-08 1.0060236951978157e-08 0.07403733167983853 0.024679103205008636 1.5440635294310695e-10 9.81133483488516 -0.1651203824223949 VQDLQK(ub)LTSHQSQNLQQPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQDLQKLTSHQSQNLQQPR 19 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 38525600.0 5844000.0 7657600.0 25024000.0 True False 5658485.418843867 10715319.613856466 18469463.69609169 1.0 1.8936727446840012 3.2640295642690442 22.43198451440749 -6.964888629466645 0.3599582339830787 0.8818600152155365 4.322799798401175 0.9999108317306452 0.008792184144135568 0.07799877623574544 0.014993304896970953 0.018386934212084195 0.11704867975728353 1.0842049120232373e-07 6.964888629466645 3.4409397831856388 VQDLQK(ub)LTSHQSQNLQQPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQDLQKLTSHQSQNLQQPR 19 1 Q6PCD5 Q6PCD5 RFWD3 E3 ubiquitin-protein ligase RFWD3 1 30605000.0 5844000.0 15513000.0 9248000.0 True False 4859544.933096666 15429428.389910592 11181714.042079248 1.0 3.175076802938097 2.300979658799838 22.212389789841765 -10.48855969227746 6.132526263146047 0.9987304977169913 2.7380282308689123 0.8405481353468989 0.3568486647937895 0.006196374029066412 0.0005167655206388573 0.3456577718788267 0.11517241132189165 3.2466861452052437e-11 10.48855969227746 1.739297733151921 VQDLSAGGQGSLTDSGPER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQDLSAGGQGSLTDSGPER 19 0 P40222 P40222 TXLNA Alpha-taxilin 0 6924100.0 1255300.0 3512400.0 2156400.0 False True 1645710.4563424916 2988363.611227965 1933276.4136494151 1.0 1.815850169579315 1.1747366653706657 20.65027910195891 -10.48425618944996 5.509289681143195 0.9992863578723198 1.4952934174749903 0.443139470898846 0.2617334920864819 0.0022973470095833627 0.0002150621930289976 0.2537665540724353 0.08447412133297061 3.279018074271476e-11 10.48425618944996 0.49600705960267055 VQDLSAGGQGSLTDSGPER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQDLSAGGQGSLTDSGPER 19 0 P40222 P40222 TXLNA Alpha-taxilin 0 3403910.0 1255300.0 1186900.0 961710.0 False True 1719418.3332069595 1134458.833446566 734573.9050391745 1.0 0.6597922166682026 0.42722232911701585 20.7134891634818 -8.122238747573824 0.1566224862351661 1.3539162371307898 1.83461214057307e-09 0.9999277560032146 0.0019991748350092643 0.09041943887683498 0.02953115668852591 0.10655570473575238 0.12014537845280916 7.546772399055624e-09 8.122238747573824 -1.3539162352961776 down VQEAIIHFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQEAIIHFR 9 0 Q9UJX3;Q9UJX3-2;H0YIW2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 0 5549300.0 1708900.0 1291600.0 2548800.0 False True 2240384.449011142 1098898.3146173672 2285074.6258160076 1.0 0.4904954214900026 1.0199475482096794 21.095314888701207 -10.950972164771153 12.405670047634834 1.060332337101369 0.7552214848498425 0.22178474620427335 0.2161479256157646 0.1134856307254813 0.00044850034743579206 0.06584976104547753 0.06976144301892798 1.1195096338797133e-11 10.950972164771153 -0.30511085225152657 VQEAIIHFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQEAIIHFR 9 0 Q9UJX3;Q9UJX3-2;H0YIW2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 0 6347200.0 1708900.0 1632600.0 3005700.0 False True 2340726.511286048 1560466.3337137613 2295815.5643346193 1.0 0.6666589736946269 0.9808132446337126 21.1585249502241 -10.554004238236287 8.848090141850331 1.00001995044786 0.8237361094754998 0.295645272030408 0.12825294405280296 5.0480110798242994e-05 2.544475066662581e-06 0.12419441396285558 0.041393459701548105 2.792516589215075e-11 10.554004238236287 -0.17628384097236016 VQEAVESMVK(ub)SLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQEAVESMVKSLER 14 1 E7EQY1;Q96C01;C9J2Y4 E7EQY1 FAM136A Protein FAM136A 1 8955000.0 2771900.0 3498600.0 2684500.0 True False 2304957.66599087 3479752.347382274 3245816.5382744055 1.0 1.5096816738655265 1.408189220203779 21.136308822961045 -9.997661301917196 4.681093551042123 0.9999910006825593 1.4589354470387832 0.9646181135072399 0.041434120786275 28549488.77997367 0.061777304822769864 2869.9357457047877 0.01418400161555522 1.0053995767931866e-10 9.997661301917196 0.4589444463562239 VQEK(ub)CQLEINFNTLQTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQEKCQLEINFNTLQTK 17 1 A0A494C1A0;P35609-2;P35609;F6THM6;O43707;O43707-2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;K7EJH8 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1 1 9234800.0 2978400.0 2903100.0 3353300.0 True False 2476671.5654919753 2887460.4240797693 4054459.5260925987 1.0 1.165863275660531 1.637059827626844 21.239971133002417 -6.952669219329505 0.5287300512017504 0.9925001144447498 1.8317669837391883 0.9993944412796096 0.006640548924427176 0.08243132431557824 0.031661277683312186 0.0074224760512925265 0.03895912931702833 1.1151435600271478e-07 6.952669219329505 0.8392668692944385 VQEK(ub)CQLEINFNTLQTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQEKCQLEINFNTLQTK 17 1 A0A494C1A0;P35609-2;P35609;F6THM6;O43707;O43707-2;P12814-2;P12814;P12814-3;P12814-4;H9KV75;K7EJH8 A0A494C1A0;O43707 ACTN2;ACTN4;ACTN1 Alpha-actinin-2;Alpha-actinin-4;Alpha-actinin-1 1 24664100.0 7429000.0 10761000.0 6474100.0 True False 9616986.94748299 10162140.890320757 5295880.229875686 1.0 1.0566865636622755 0.5506797772312411 23.19715353017927 -6.879074958492218 1.0849048280701103 1.0347246487055597 0.5154437420083297 0.9729333641278933 0.03724042116897258 0.12845454406332021 0.2772418483389226 0.026462956927401745 0.06384865488606829 1.3210676004770477e-07 6.879074958492218 -0.51928090669723 VQELGLSAPLTVLPTITCGHTIEILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQELGLSAPLTVLPTITCGHTIEILR 26 0 P0DN79;P35520;P35520-2;H7C2H4 P0DN79 CBS Cystathionine beta-synthase 0 105414000.0 27571000.0 54255000.0 23588000.0 False True 41827222.71009362 44572771.35375022 18925821.461012322 1.0 1.0656402329814276 0.4524761682645786 25.31793887172264 -6.880415259322929 1.0775250695384677 1.04090567187992 0.4086818309473317 0.9740169394740802 0.04430960506020949 0.12726082708123598 0.270093002978022 0.031666007884805676 0.07665506013337768 1.3169968635306201e-07 6.880415259322929 -0.6322238409325882 down VQELGLSAPLTVLPTITCGHTIEILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQELGLSAPLTVLPTITCGHTIEILR 26 0 P0DN79;P35520;P35520-2;H7C2H4 P0DN79 CBS Cystathionine beta-synthase 0 49951000.0 27571000.0 15468000.0 6912000.0 False True 35691203.00566071 14607192.202535205 5654086.923109116 1.0 0.40926589670341085 0.15841682114812336 25.089065193815088 -9.689122248099777 0.23907673204409843 1.4852553518045102 1.668595733662987e-12 0.9991599724153897 0.010225024856658738 1.1113548678090344 0.10094314750332697 0.49988322395755946 0.1154480674904383 2.0458686709421287e-10 9.689122248099777 -1.4852553518028415 VQEQELK(ub)SEFEQNLSEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQEQELKSEFEQNLSEK 17 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 9950100.0 2704400.0 4039800.0 3205900.0 True False 2618550.3023137185 5652913.207278696 2366178.615061555 1.0 2.1587949646351463 0.9036216004599297 21.32033688852866 -6.664063663745442 1.9583028974480967 1.7433885758227332 0.9087936433541449 0.2530738242485633 0.4929128011961624 0.47489518269789 3.5050677854749863 0.20304954043518184 0.5467545127179306 2.167386361782492e-07 6.664063663745442 -0.8345949324685883 VQEQELK(ub)SEFEQNLSEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQEQELKSEFEQNLSEK 17 1 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 1 8619300.0 2704400.0 3589400.0 2325500.0 True False 2248828.425233853 3570063.189759886 2811751.2981028603 1.0 1.5875213732184301 1.2503182842019038 21.100742163962938 -10.240894277055988 5.69086703835363 0.9999895803128906 1.4189198284164763 0.6729747485127361 0.1376625847424834 3.502403007109498e-05 4.672003379763422e-06 0.13329759508629155 0.04443040815837014 5.7425623987817894e-11 10.240894277055988 0.4189302481035857 VQESADELQK(ub)MLQEDELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQESADELQKMLQEDELR 18 1 P84085 P84085 ARF5 ADP-ribosylation factor 5 1 21784600.0 9968600.0 11816000.0 0.0 True False 15123095.002279177 9707342.481170624 0.0 1.0 0.6418886133894978 0.0 23.850250087335578 -7.552501528701869 0.694941792074923 0.9947906344132709 5.831093774634686e-15 0.9870638421335007 0.04705210794601787 0.12057340325336734 0.14451646153927403 0.042054228065210725 0.07647772173216284 2.8021957580152123e-08 7.552501528701869 -0.994790634413265 down VQESTK(ub)GPDEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQESTKGPDEAK 12 1 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 13716000.0 4120600.0 6522300.0 3073100.0 True False 5402146.503947166 5549198.26372628 2755125.0912567363 1.0 1.027220987004271 0.5100056226249435 22.36510133498594 -6.8944839777408875 0.9955098050075888 1.0248776889057871 0.4614122916123201 0.9836155352345131 0.03042111214310364 0.11557924344938372 0.2012132974169749 0.023136377265864375 0.05869092457529759 1.2750171377924023e-07 6.8944839777408875 -0.563465397293467 VQESTK(ub)GPDEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQESTKGPDEAK 12 1 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 15117000.0 5045500.0 7063900.0 3007600.0 True False 4885333.364267068 9884552.107751865 2219819.3339340356 1.0 2.023311690467374 0.4543844131846811 22.220025581172962 -6.730704938889888 1.7207927117329993 1.6153368232683127 0.45521730873473937 0.5625079901301232 0.4301508559706219 0.3349004032721358 1.9431450513507338 0.1980736197575937 0.49108951107447635 1.8590670824626742e-07 6.730704938889888 -1.1601195145335734 VQESTK(ub)GPDEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQESTKGPDEAK 12 1 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 12453000.0 4857100.0 2250600.0 5345300.0 True False 7368575.801573955 1848962.8459819406 4288799.112071785 1.0 0.25092540210918307 0.5820390842903023 22.81295437147242 -10.564182385021475 6.414683311252765 1.0009341617803134 0.4164822432036279 0.8054807700169979 0.13517659469963678 0.0018084746414674785 0.0001228683585464576 0.1310686615156282 0.04362805833906026 2.7278319700118895e-11 10.564182385021475 -0.5844519185766854 VQESTK(ub)GPDEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQESTKGPDEAK 12 1 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 11881600.0 4120600.0 5249300.0 2511700.0 True False 5644097.175027965 5017368.568886228 1918488.1900852586 1.0 0.888958572698807 0.3399105526697019 22.428311396508832 -6.940054345000252 0.6590570322892897 1.0061571476071445 0.19161241658784783 0.9981710191323604 0.012341549194105001 0.08774183127684797 0.054496675105673784 0.012018528622860123 0.047244154119699046 1.1480099574448238e-07 6.940054345000252 -0.8145447310192966 down VQESTK(ub)GPDEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQESTKGPDEAK 12 1 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 9622400.0 4857100.0 3104200.0 1661100.0 True False 6287611.697754688 2931448.541188895 1358796.8443253117 1.0 0.4662260778978635 0.21610699095978517 22.584080693564868 -9.68597865900682 0.20657370808696487 1.5345467983171364 5.627005235398549e-13 0.9994125444988725 0.007924012789247111 1.1232293158351994 0.08668445064857226 0.4986923170509874 0.13846078413402588 2.0607311739842225e-10 9.68597865900682 -1.5345467983165737 VQESTKGPDEAK(ub)IK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQESTKGPDEAKIK 14 2 O43390;O43390-3;B4DT28;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 4285620.0 889620.0 1155500.0 2240500.0 True False 1151630.627031876 1091195.4092338656 1832751.9894713499 1.0 0.947522047104833 1.5914408200439611 20.13524663159055 -6.887150001687924 1.0391243645654904 0.9630006516608387 1.643821569673334 0.9790094252993305 0.042300128191432806 0.12148474970748606 0.23561426745318997 0.031127780977105605 0.0768449777207852 1.296731313459356e-07 6.887150001687924 0.6808209180124953 VQFGASHVFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQFGASHVFK 10 0 H0Y7R8;Q5TIG5;A8MQ02;J3KN01;P55196-2;P55196-6;P55196-3;P55196-1;P55196;P55196-5 H0Y7R8 MLLT4 Afadin 0 8933600.0 3041100.0 2471500.0 3421000.0 False True 3986911.550054289 2102761.8338315454 3067027.7365491814 1.0 0.527416223668898 0.7692740854778728 21.92684016871171 -10.073860784180138 4.907318394407653 1.0000100289748934 0.648345154570623 0.7381319672426293 0.0987380586283082 1.083425246481086e-05 2.044695081090345e-06 0.09560543962327901 0.031867571390661965 8.436051373434908e-11 10.073860784180138 -0.3516648744042704 VQFGASHVFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQFGASHVFK 10 0 H0Y7R8;Q5TIG5;A8MQ02;J3KN01;P55196-2;P55196-6;P55196-3;P55196-1;P55196;P55196-5 H0Y7R8 MLLT4 Afadin 0 5035000.0 3041100.0 1993900.0 0.0 False True 4165476.8526373636 1905802.905054437 0.0 1.0 0.45752334545990375 0.0 21.9900502302346 -8.06726614037688 0.5678917797630848 1.018151288298184 3.197328957072458e-18 0.9901254976013798 0.04061661641681344 0.11384088066664845 0.16760879275537763 0.04814476179571742 0.0752582368254002 8.565128040194799e-09 8.06726614037688 -1.018151288298184 VQFGASHVFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQFGASHVFK 10 0 H0Y7R8;Q5TIG5;A8MQ02;J3KN01;P55196-2;P55196-6;P55196-3;P55196-1;P55196;P55196-5 H0Y7R8 MLLT4 Afadin 0 4700900.0 1315700.0 1848800.0 1536400.0 False True 1703199.5863243213 1745912.6547741855 1256790.9647952612 1.0 1.025078134584358 0.7378999941560251 20.69981607382312 -6.885626881168874 1.047871993376046 1.0170864447800978 0.7152137782980922 0.9779497373899698 0.01928486691010669 0.12276452707199266 0.2431316975875028 0.014096712607428319 0.03463429613008571 1.301287082916843e-07 6.885626881168874 -0.3018726664820056 VQFSLQLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQFSLQLFK 9 0 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 0 15324400.0 9611100.0 3544800.0 2168500.0 False True 9306000.891350146 4960257.12588779 1600504.7963944532 1.0 0.5330170482251199 0.17198631453840818 23.149729894603986 -8.020634201311573 0.3365277460588112 1.0980070108124393 1.0696996283959185e-21 0.9986886285277536 0.01227458021030214 0.09686208669537587 0.06892527825128664 0.0552375423971064 0.08717175114603049 9.535990257313947e-09 8.020634201311573 -1.0980070108124393 down VQFSLQLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQFSLQLFK 9 0 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 0 200220000.0 60612000.0 58101000.0 81507000.0 False True 91952835.33075309 47732422.60481508 65397105.7242128 1.0 0.5190968003664292 0.7112027104871786 26.454390724488242 -10.169146264358861 5.344489251955897 1.0000139573479958 0.6151497554266897 0.8425462727063416 0.07842690939520154 1.3043372887479937e-05 2.027802277909732e-06 0.0759392793105814 0.025312176165119857 6.774133257746024e-11 10.169146264358861 -0.3848642019213061 VQFSLQLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQFSLQLFK 9 0 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 0 12156170.0 907670.0 3877900.0 7370600.0 False True 1243260.1278594448 3706561.555499576 5629816.082271926 1.0 2.9813242397480124 4.528268828153394 20.245696753011064 -7.70588375023687 0.2210389990944744 1.4255853022887533e-16 6.3997674232171065 0.9998552400746639 0.017374188851415635 0.13509758979696074 0.029703209426436065 0.2541253325362142 0.45873242540235953 1.9684131141193565e-08 7.70588375023687 6.3997674232171065 VQFSLQLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQFSLQLFK 9 0 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 0 20618200.0 9611100.0 4682400.0 6324700.0 False True 7992055.493922884 4657174.981816373 7647165.527891276 1.0 0.58272555606723 0.9568458994943341 22.930135170038263 -10.313543671825286 8.213435350813299 1.0000005296238959 0.769785727780782 0.3354912922242149 0.1527339906318686 1.4812399248686722e-06 1.239540093371616e-07 0.1478843898761444 0.049294683509752225 4.857986774922071e-11 10.313543671825286 -0.23021480184311383 VQFSLQLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQFSLQLFK 9 0 Q96CG3 Q96CG3 TIFA TRAF-interacting protein with FHA domain-containing protein A 0 172296000.0 60612000.0 64323000.0 47361000.0 False True 78463428.84114128 60743368.50553877 38741783.96489742 1.0 0.7741615349046379 0.49375593874867296 26.22551704658069 -6.968208142582418 0.29789237403798796 1.0498660023111102 0.2092914240080894 0.9999648377137442 0.0012278841807802211 0.07688850734550826 0.011100151189923505 0.0047013470973786215 0.02520507052682613 1.0759494240547725e-07 6.968208142582418 -0.8405745783030207 down VQFSNK(ub)SANMDHWQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQFSNKSANMDHWQQR 16 1 Q9NZL9;Q9NZL9-2;Q9NZL9-4;H7C0X7;Q9NZL9-3 Q9NZL9 MAT2B Methionine adenosyltransferase 2 subunit beta 1 14181900.0 5312400.0 7149900.0 1719600.0 True False 6964607.84535478 6083162.7900919095 1541672.287567954 1.0 0.8734393845518851 0.22135808961537026 22.73161069092462 -6.939138204664834 0.6675346846356154 1.007439650336392 0.04988379748210278 0.9980488020803677 0.015069839825533619 0.08816206077995188 0.05641703688550517 0.014575265964470313 0.056339815273563756 1.1504342303011346e-07 6.939138204664834 -0.9575558528542892 down VQFSNK(ub)SANMDHWQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQFSNKSANMDHWQQR 16 1 Q9NZL9;Q9NZL9-2;Q9NZL9-4;H7C0X7;Q9NZL9-3 Q9NZL9 MAT2B Methionine adenosyltransferase 2 subunit beta 1 13816700.0 5312400.0 5671000.0 2833300.0 True False 7276537.842211945 5420436.468510807 2164132.8936451618 1.0 0.7449197112761919 0.29741244264419325 22.79482075244751 -6.962524056914222 0.39826695007139407 1.025075230450863 0.0009623691561413344 0.9998526623921489 0.0035248759474243775 0.07881149336640661 0.017887916792554828 0.005759713910364501 0.03751830063568429 1.090124105367694e-07 6.962524056914222 -1.0241128612947217 down VQFSNK(ub)SANMDHWQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQFSNKSANMDHWQQR 16 1 Q9NZL9;Q9NZL9-2;Q9NZL9-4;H7C0X7;Q9NZL9-3 Q9NZL9 MAT2B Methionine adenosyltransferase 2 subunit beta 1 23641800.0 9993900.0 11282000.0 2365900.0 True False 8310370.65483827 11221221.626698337 2860598.7513143695 1.0 1.350267285631283 0.34422035672367257 22.98648139409016 -6.8126478662126155 1.4033221020466922 1.190297375871431 0.32552012177708445 0.8666651530838384 0.1522610962823394 0.20319419953395115 0.7881410212605583 0.08530226363642732 0.1971004797717803 1.539402309534885e-07 6.8126478662126155 -0.8647772540943466 down VQGGALEDSQLVAGVAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQGGALEDSQLVAGVAFK 18 0 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 19721700.0 4115600.0 10440000.0 5166100.0 False True 5395591.4555271 8882392.694801275 4631561.528730405 1.0 1.6462315147493958 0.8583973725412358 22.363349683474176 -6.688708317320441 1.8708415889953187 1.4056334339255383 0.86115078444727 0.3644429615466449 0.2733823586396127 0.41946086509862385 2.8453928283519074 0.11694009643508167 0.3050353056358625 2.0478195401033616e-07 6.688708317320441 -0.5444826494782683 VQGGALEDSQLVAGVAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQGGALEDSQLVAGVAFK 18 0 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 32651600.0 9724700.0 6247900.0 16679000.0 False True 9415994.721531661 8742719.052368078 12310269.54072544 1.0 0.9284965965811349 1.3073785515804728 23.16668208094711 -6.857878582042954 1.1963699654284217 0.9614018488210454 1.3249995587393377 0.9510125679107981 0.036379313959852604 0.14900460977476687 0.4064614664800993 0.023735994350717667 0.055282634130611734 1.3871435855805218e-07 6.857878582042954 0.3635977099182923 VQGGALEDSQLVAGVAFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQGGALEDSQLVAGVAFK 18 0 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 68161500.0 8398500.0 44231000.0 15532000.0 False True 12741138.512593705 36337632.471619636 12462093.392082574 1.0 2.8519925778769677 0.9780988865135314 23.60299086277003 -6.648872900688437 2.0122372063342002 2.2028527971270866 0.9859397474290655 0.18947633436732814 0.7906762593633543 0.5114027536751967 3.9676961013819945 0.31878769690675 0.8758978810806582 2.244538707591857e-07 6.648872900688437 -1.2169130496980212 VQGGALEDSQLVAGVAFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQGGALEDSQLVAGVAFK 18 0 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 21295600.0 4115600.0 6742000.0 10438000.0 False True 5637248.539908049 6444116.147187423 7972759.377357933 1.0 1.1431314588255737 1.4142997813411966 22.426559744997068 -6.961090479482777 0.4197848351931201 0.9879860741252413 1.579670670494681 0.9998085229425626 0.002377395972826067 0.07931388292686548 0.019709026034181305 0.00350731588193464 0.022574030246117906 1.0937284787432542e-07 6.961090479482777 0.5916845963694397 VQGGALEDSQLVAGVAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQGGALEDSQLVAGVAFK 18 0 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 18909100.0 9724700.0 4773500.0 4410900.0 False True 8086518.927256197 4747784.208034431 5333198.796302694 1.0 0.5871233655351601 0.6595172588203265 22.947087356381385 -10.741037927279239 6.926992088955099 1.0060554156866868 0.6233203121778119 0.9730441344282772 0.02955468317369253 0.0027823441733480225 0.00010401638204657652 0.02880752562101805 0.009538732977845642 1.8153571192830202e-11 10.741037927279239 -0.38273510350887485 VQGGALEDSQLVAGVAFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQGGALEDSQLVAGVAFK 18 0 Q99832;Q99832-3;Q99832-4 Q99832 CCT7 T-complex protein 1 subunit eta 0 32990600.0 8398500.0 17739000.0 6853100.0 False True 10872023.809185062 16751809.056165794 5605906.118744088 1.0 1.5408179148773835 0.5156267330842327 23.37411718486248 -6.7633757675913895 1.5996797782506473 1.3128220165534654 0.5112356023171379 0.7045894018022009 0.22759440326542116 0.27730289517602713 1.3992696026574851 0.11221445811735775 0.26878690510438147 1.724345279266284e-07 6.7633757675913895 -0.8015864142363275 VQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQK 32 0 J3KRX0;P34810-2;P34810-3;P34810 J3KRX0 CD68 Macrosialin 0 61779000.0 16325000.0 25199000.0 20255000.0 False True 24766218.517365277 20702041.569314368 16251590.371918108 1.0 0.8358983651379301 0.6561999103950009 24.56187026865704 -6.969959948594384 0.25914123379122145 1.0509823921903223 0.4357904680477517 0.9999820669847154 0.0005945459994505792 0.07631570375167995 0.009076648417182651 0.003772158631807962 0.016976756859452182 1.0716181272007143e-07 6.969959948594384 -0.6151919241425706 VQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQGSCEGAHPHLLLSFPYGHLSFGFMQDLQQK 32 0 J3KRX0;P34810-2;P34810-3;P34810 J3KRX0 CD68 Macrosialin 0 35811200.0 16325000.0 7354200.0 12132000.0 False True 21133034.313859165 6944932.30513864 9924100.484832149 1.0 0.32862920686141667 0.4696013046419873 24.332996590749488 -9.966830110282697 7.10208096934454 1.0000000276143572 0.39911525575581935 0.9603559979495545 0.05755161792202513 2.5160149270922515e-08 3.624427390363804e-09 0.05572411693087325 0.018574704813274247 1.079368873140043e-10 9.966830110282697 -0.600884771858538 VQIAVANAQELLQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQIAVANAQELLQR 14 0 Q9Y5L4 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 0 71496000.0 19684000.0 34071000.0 17741000.0 False True 25805914.620127134 28987739.607717782 15905331.50368869 1.0 1.1232982839177887 0.6163444209523751 24.621198428123098 -6.8424313115157664 1.2710624844360898 1.065584707101061 0.5988520674029916 0.9285544017632219 0.05770039332687596 0.1659769847637628 0.5198352955474865 0.03558095669031407 0.08203261363212397 1.43737037142958e-07 6.8424313115157664 -0.46673263969806933 VQIAVANAQELLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQIAVANAQELLQR 14 0 Q9Y5L4 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 0 61390000.0 17980000.0 11661000.0 31749000.0 False True 17409234.741754405 16317298.11131166 23432984.450416207 1.0 0.9372783096649366 1.3460088739118674 24.0533494520058 -6.867742433603711 1.1458843751262706 0.9649636490863154 1.368949866632476 0.9623822406673331 0.03485862763229158 0.1390425613144042 0.34262025775386984 0.023638612325099694 0.05575982595047991 1.355993370941121e-07 6.867742433603711 0.4039862175461606 VQIAVANAQELLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQIAVANAQELLQR 14 0 Q9Y5L4 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 0 58312600.0 7624900.0 41165000.0 9522700.0 False True 11567530.754858106 33818784.12638701 7640534.1710523255 1.0 2.923595782287751 0.6605155700877191 23.463577598846086 -6.681491932618009 1.8962542403575269 2.2154249693913397 0.6689581304413715 0.3310970943458874 0.8149974036988322 0.4352268606310918 3.026918562508522 0.3446816752451832 0.9074515094588753 2.08213108218122e-07 6.681491932618009 -1.5464668389499683 VQIAVANAQELLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQIAVANAQELLQR 14 0 Q9Y5L4 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 0 85874000.0 19684000.0 23984000.0 42206000.0 False True 26961706.740098603 22924307.57551812 32237812.059855245 1.0 0.8502543179666037 1.1956888475427927 24.68440848964599 -6.788863170125687 1.5006755476919222 0.9161853552186453 1.199259393958754 0.7977034266685865 0.06361521762018021 0.23703637549274845 1.0545541121372888 0.03336774010225481 0.0781938397398087 1.6260609857776975e-07 6.788863170125687 0.2830740387401086 VQIAVANAQELLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQIAVANAQELLQR 14 0 Q9Y5L4 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 0 41381800.0 17980000.0 9453800.0 13948000.0 False True 14951166.649055112 9402870.502967622 16864462.311734576 1.0 0.6289054709695091 1.1279696566555482 23.833754727440077 -6.7076024905120155 1.8038648731871338 0.7713021584222127 1.1267109727333058 0.45367342936915 0.15643702744432722 0.3799060206296592 2.408239719671417 0.06905480474917063 0.17593609732418247 1.960638423686199e-07 6.7076024905120155 0.35540881431109306 VQIAVANAQELLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQIAVANAQELLQR 14 0 Q9Y5L4 Q9Y5L4 TIMM13 Mitochondrial import inner membrane translocase subunit Tim13 0 36029900.0 7624900.0 18295000.0 10110000.0 False True 9870583.359249298 17276867.167402513 8270083.737360132 1.0 1.7503390163067827 0.8378515672643191 23.234703920938536 -6.688245948335896 1.8729303793889105 1.4711905552961773 0.8410932459095799 0.36213768069969443 0.3174548404838036 0.4204291404883924 2.858081796269259 0.13567352030436156 0.35404966770995905 2.0500008997286827e-07 6.688245948335896 -0.6300973093865974 VQIEHISSLIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQIEHISSLIK 11 0 O00231;O00231-2 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 18116400.0 3283500.0 5939100.0 8893800.0 False True 4304700.297459231 5053009.430430484 7973554.891353733 1.0 1.1738353616424653 1.852290366430382 22.03748136689506 -6.945440681328033 0.6068491631369015 0.9924587848072501 2.0688075511643698 0.9987930713509997 0.012774687896960827 0.0853700443872979 0.04395082813376966 0.013024220712394499 0.05714630262517862 1.1338596972185601e-07 6.945440681328033 1.0763487663571196 VQIEHISSLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQIEHISSLIK 11 0 O00231;O00231-2 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 10845000.0 2848700.0 1764900.0 6231400.0 False True 2758269.577799544 2469633.773831913 4599209.4020071 1.0 0.8953562022034498 1.6674256349070118 21.395332033989177 -6.872695857492961 1.1197871866412283 0.9397386008214349 1.7150100264190988 0.9672979764742594 0.0618410424596781 0.13429368899627858 0.3130966007247344 0.04278685387551128 0.1017974457027226 1.3406152103614547e-07 6.872695857492961 0.7752714255976639 VQIEHISSLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQIEHISSLIK 11 0 O00231;O00231-2 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 16388500.0 3283500.0 6493600.0 6611400.0 False True 4497498.683251059 6206691.280536375 5049923.48605712 1.0 1.3800318171632706 1.1228293417546342 22.100691428417953 -10.449148724412336 5.1316555753696225 0.9996253384927074 1.2514305794589604 0.5602775828225206 0.1050024708886774 0.0004507502145441744 4.838519605215143e-05 0.10181769642180814 0.03388940175520238 3.555095532557895e-11 10.449148724412336 0.251805240966253 VQIEHISSLIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQIEHISSLIK 11 0 O00231;O00231-2 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 4118400.0 2848700.0 0.0 1269700.0 False True 2368820.268807749 0.0 1535188.3995705028 1.0 0.0 0.6480814183269289 21.175737309423454 -10.292544525516652 7.477523616065034 1.0000034666142976 0.32404070916346456 0.5919216556041297 0.26457813111336437 1.5290551143770742e-05 1.4467923749215783e-06 0.25617798995375596 0.0853922246310619 5.098653215695328e-11 10.292544525516652 -0.6759627574508331 VQILK(ub)DYVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQILKDYVR 9 1 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 1 11795000.0 2351700.0 2370100.0 7073200.0 True False 3044322.0089373733 2238201.8515146547 5785950.177160798 1.0 0.7352053576933879 1.9005710171836898 21.537689535303304 -6.846975805897194 1.2495545823511687 0.8589792961455223 1.944520519705299 0.9357955814914773 0.12638913136656071 0.16081337747350788 0.4847042012487312 0.07920488884747968 0.18297001672872182 1.4224080258165618e-07 6.846975805897194 1.0855412235597768 VQIPIMLVGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQIPIMLVGNK 11 0 Q15382;C9J931;C9J469 Q15382 RHEB GTP-binding protein Rheb 0 4660900.0 1282400.0 1669800.0 1708700.0 False True 1681238.8187792676 1420672.3488294224 1531900.115007773 1.0 0.8450151953194608 0.9111734144468969 20.681093242260147 -10.086402570231979 4.3399662639522365 1.0000123351745835 0.878094304870333 0.8190729539058748 0.027008979907537534 37600623.52916106 10557.255395156744 4964.883139889128 0.009245892211643455 8.195914699794178e-11 10.086402570231979 -0.12191803030425052 VQIPIMLVGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQIPIMLVGNK 11 0 Q15382;C9J931;C9J469 Q15382 RHEB GTP-binding protein Rheb 0 4818420.0 1282400.0 928120.0 2607900.0 False True 1756537.9355569254 887112.5895175908 1991967.7313864492 1.0 0.5050346887249686 1.1340305785965725 20.744303303783038 -6.696889567115672 1.8420394063271426 0.6917103082673103 1.1320485144194288 0.4027732538170097 0.20905288316928694 0.40203980982021126 2.6499200784872747 0.09061720835660135 0.2339357747637623 2.0096037519240552e-07 6.696889567115672 0.4403382061521185 VQIVISSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQIVISSAR 9 0 E5RGY5;E5RHL4;H3BQB7;P0CG13 E5RGY5 CHTF8 Chromosome transmission fidelity protein 8 homolog 0 6468300.0 1375700.0 2301500.0 2791100.0 False True 1803556.0222977526 1958125.171176737 2502303.7461217265 1.0 1.085702438387282 1.38742778998002 20.78241280633148 -6.947810131813465 0.582397587183144 0.9964248087443405 1.4916906056025199 0.9990179681155645 0.0052070284791899775 0.08437735845240744 0.039696141505740246 0.005441559007593894 0.02522148064074466 1.1276903607272107e-07 6.947810131813465 0.4952657968581794 VQIVISSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQIVISSAR 9 0 E5RGY5;E5RHL4;H3BQB7;P0CG13 E5RGY5 CHTF8 Chromosome transmission fidelity protein 8 homolog 0 4495310.0 1671800.0 816410.0 2007100.0 False True 1618729.6240970527 1142406.7705219057 1481380.2982906643 1.0 0.7057427957798414 0.915149927596461 20.626430602185668 -9.966605050648111 5.735564715619694 1.0000002241963855 0.8104463624760222 0.5221019444789528 0.08549010357548226 2.451039029942516e-07 4.408596044511693e-08 0.08277553552853267 0.02759181228438991 1.079928367512315e-10 9.966605050648111 -0.18955386172036326 VQIVISSAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQIVISSAR 9 0 E5RGY5;E5RHL4;H3BQB7;P0CG13 E5RGY5 CHTF8 Chromosome transmission fidelity protein 8 homolog 0 6700300.0 1375700.0 1563600.0 3761000.0 False True 1884333.4668946208 1494514.9818662503 2872729.260226399 1.0 0.7931265925713292 1.5245333751677475 20.84562286785437 -6.831168727182686 1.3228272236050795 0.8895507135260808 1.5446682546653285 0.9081649613742909 0.09328866740252435 0.17937423539881955 0.6134811049347663 0.055366621505973226 0.12740155728991787 1.4751333198119266e-07 6.831168727182686 0.6551175411392477 VQIVISSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQIVISSAR 9 0 E5RGY5;E5RHL4;H3BQB7;P0CG13 E5RGY5 CHTF8 Chromosome transmission fidelity protein 8 homolog 0 3494350.0 1671800.0 884610.0 937940.0 False True 1390175.773297571 879844.4303486621 1134058.9174554283 1.0 0.6329015706133506 0.8157665665294829 20.406835877619944 -10.149234078789673 5.079741706570318 1.0000131435242443 0.7243340685710254 0.7518615307335661 0.07465432196980301 1.111302059217969e-05 1.8612580171431165e-06 0.07228718155623419 0.024094578809092652 7.091954182950658e-11 10.149234078789673 -0.27567907495321886 VQIVISSAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQIVISSAR 9 0 E5RGY5;E5RHL4;H3BQB7;P0CG13 E5RGY5 CHTF8 Chromosome transmission fidelity protein 8 homolog 0 11996900.0 2739100.0 5693600.0 3564200.0 False True 3545818.9457330224 5376746.154923359 2915552.171780312 1.0 1.516362295202253 0.8222507173663893 21.757687441499368 -6.70750314361823 1.8040503560973316 1.3182521641797829 0.8239940769254254 0.45327173653765285 0.21767882416127013 0.3801109177162705 2.4099331079473414 0.09607710278383635 0.24482788640835443 1.9610869801976108e-07 6.70750314361823 -0.4942580872543575 VQK(ub)AGQQALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQKAGQQALR 10 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 3630060.0 931260.0 1620300.0 1078500.0 True False 1220890.8783346675 1378557.5558799328 966907.1657025124 1.0 1.1291406794359276 0.7919685394172191 20.21950282917395 -6.8028730746336405 1.4440120524978146 1.0709952777341907 0.7869694503054636 0.8404692952070427 0.055478548900254984 0.21668077536218217 0.8916508958345063 0.030219595844686142 0.07016477792615704 1.5744429383472897e-07 6.8028730746336405 -0.28402582742872706 VQK(ub)AGQQALR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQKAGQQALR 10 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 2479710.0 727950.0 832230.0 919530.0 True False 704841.6257096843 1164543.7790221162 678677.5076913042 1.0 1.6522063064160992 0.9628794369344514 19.426939602201983 -6.658709603741698 1.9774814789653778 1.4202778060422907 0.9657684593781273 0.23000525978372832 0.2777840104610429 0.48759702235919555 3.6640174954114904 0.11354476316601933 0.30789102872524715 2.1942716712140705e-07 6.658709603741698 -0.4545093466641634 VQK(ub)AGQQALR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQKAGQQALR 10 1 Q92616 Q92616 GCN1L1 Translational activator GCN1 1 3999060.0 931260.0 1512300.0 1555500.0 True False 1275571.9883552238 1445481.585492663 1188122.9365280967 1.0 1.1332026719687753 0.9314432641783804 20.282712890696843 -6.728659776729899 1.7280004047114232 1.080281389478932 0.9315904951518393 0.5530364577909117 0.05600166112243731 0.33878499698378295 1.9811884973265617 0.025688134885300064 0.06384314050368531 1.867842372528368e-07 6.728659776729899 -0.1486908943270927 VQK(ub)ASTEGVAIQGQQGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQKASTEGVAIQGQQGTR 18 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 6927300.0 1118300.0 2131400.0 3677600.0 True False 1082800.178626472 2982479.1351041635 2714326.2343648784 1.0 2.7544132278288203 2.5067655952993944 20.046335599987014 -10.299207573449962 9.211367528522636 0.999999428408092 2.6305894115641073 0.982994420230918 0.10110172261756108 1.1868745341945514e-06 9.010580304138081e-08 0.09789135552818362 0.0326304406642247 5.0210254947177906e-11 10.299207573449962 1.6305899831560153 VQK(ub)ASTEGVAIQGQQGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQKASTEGVAIQGQQGTR 18 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 23425900.0 3010900.0 3625000.0 16790000.0 True False 4567755.426274744 2978090.4277457283 13471449.140681567 1.0 0.6519811482495518 2.9492492227562797 22.12305397511541 -6.86829699485982 1.1431291748947234 0.8050783780180204 3.079469198037542 0.9629504648809545 0.19458972503387034 0.13849486135844427 0.3393181700941185 0.13224515955253127 0.31218902163353207 1.3542629748367532e-07 6.86829699485982 2.2743908200195215 up VQK(ub)ASTEGVAIQGQQGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQKASTEGVAIQGQQGTR 18 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 6752800.0 1118300.0 3267600.0 2366900.0 True False 929915.999090008 3249996.79023218 2861807.846690889 1.0 3.494935879598312 3.077490708291266 19.82674087542129 -9.292823655495415 9.015187797512871 1.0000000001509546 3.2862132939538995 0.9756050081665639 0.17042127755056122 0.0 3.7085308068836844e-18 0.16500969244725008 0.05500323081575004 5.095377259482827e-10 9.292823655495415 2.2862132938029447 VQK(ub)ASTEGVAIQGQQGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQKASTEGVAIQGQQGTR 18 1 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 1 19511300.0 3010900.0 3072400.0 13428000.0 True False 3897669.4037120133 2901418.2391433427 10984241.782915115 1.0 0.7443982386962134 2.818156350678198 21.89418029720786 -6.876048984723116 1.1016622727010343 0.8485478134640771 2.9543900037191153 0.9703532874277571 0.1589670408128814 0.13118428221164527 0.2939623037683274 0.11152714334849513 0.2671794704987817 1.3303043625002598e-07 6.876048984723116 2.1058421902550384 up VQK(ub)LLQDFFNGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQKLLQDFFNGR 12 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 11323600.0 2359500.0 6653200.0 2310900.0 True False 3093327.349430504 5660568.493970473 2071790.2357180638 1.0 1.829928699596766 0.6697610700980258 21.560728083129803 -6.7146498307439035 1.7783900494570861 1.5077750294530414 0.6720678014992306 0.4872459854596921 0.3494847922902804 0.3658141397366311 2.257963835017303 0.15621381848805377 0.3946705744447873 1.9290796926654646e-07 6.7146498307439035 -0.8357072279538108 VQK(ub)LLQDFFNGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQKLLQDFFNGR 12 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 23242500.0 8799500.0 8733200.0 5709800.0 True False 8520164.689102769 12220412.303036371 4214232.089671685 1.0 1.43429296838196 0.49461861870600443 23.022449886378052 -6.781049316632059 1.5319350648416858 1.2455732665525798 0.4869481781588917 0.7710350207621102 0.18373849103120113 0.2489476228560278 1.1540680897015607 0.09446290320401224 0.2226838282143074 1.6555819519581467e-07 6.781049316632059 -0.7586250883936881 down VQK(ub)LLQDFFNGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQKLLQDFFNGR 12 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 74151100.0 4036100.0 15095000.0 55020000.0 True False 6123058.778434188 12401179.3122267 44145272.88387734 1.0 2.0253242310696837 7.209676483812284 22.54582110166445 -6.939555685999946 0.6636838510959967 0.941339193352209 8.589646798612637 0.9981051281440924 0.1183159176477741 0.08796990715690377 0.055537055438656634 0.11478761937384313 0.447087414465574 1.1493288650092139e-07 6.939555685999946 7.648307605260428 VQK(ub)LLQDFFNGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQKLLQDFFNGR 12 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 10494800.0 2359500.0 4474600.0 3660700.0 True False 3231870.913089958 4276897.376476537 2796118.0544830603 1.0 1.323350310544254 0.8651700917750211 21.623938144652694 -6.717104136405136 1.7698572239935417 1.1973319147549613 0.86600453429097 0.49873452699223486 0.13611792146033297 0.3609886776506691 2.2082893280917193 0.061106219162693425 0.15391734412175978 1.9182087318034194e-07 6.717104136405136 -0.33132738046399124 VQK(ub)LLQDFFNGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQKLLQDFFNGR 12 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 20558300.0 8799500.0 6523500.0 5235300.0 True False 7317174.133946627 6488356.610686636 6329977.024707762 1.0 0.8867298347575395 0.8650849233368721 22.802855161812328 -13.999999994322064 0.23271087942571844 1.7241287728842514 0.8548288021704364 0.9995136043721918 0.0013047565960570418 13.37733667602202 0.1527250755975562 4.482740273599332 0.011049308761864825 1.0000000130739317e-14 13.999999994322064 -0.8692999707138149 VQK(ub)LLQDFFNGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQKLLQDFFNGR 12 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 51758100.0 4036100.0 11621000.0 36101000.0 True False 5224811.013425242 10974281.13431999 29530988.42754085 1.0 2.1004168583555245 5.652068247379755 22.3169474237569 -6.9497963824166655 0.5610739683523137 0.9538076595045978 6.968729937615564 0.9991852118939455 0.05666470075355757 0.08356759691119704 0.0363014483638506 0.06066284173470595 0.2953078967825309 1.1225446324161597e-07 6.9497963824166655 6.014922278110966 VQK(ub)VIADEEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQKVIADEEQK 11 1 Q96DX7 Q96DX7 TRIM44 Tripartite motif-containing protein 44 1 2673390.0 886680.0 1126500.0 660210.0 True False 1162446.0666213355 958430.591062608 591897.8023815076 1.0 0.8244946742762 0.5091830230901518 20.14873235115951 -6.962086899202861 0.40495010835259254 1.016414523702931 0.3056572935300109 0.9998399383354071 0.0025691019433987977 0.07896389195146226 0.01843753887225741 0.004056615578001896 0.026370850167910607 1.0912219689334843e-07 6.962086899202861 -0.71075723017292 VQK(ub)VIADEEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQKVIADEEQK 11 1 Q96DX7 Q96DX7 TRIM44 Tripartite motif-containing protein 44 1 2517470.0 886680.0 1032100.0 598690.0 True False 1214509.5576260248 986498.4093017112 457291.75240758964 1.0 0.8122607212988904 0.3765237988752001 20.2119424126824 -6.95703357271969 0.4753994763460856 1.010925387976597 0.1598327022670019 0.9996438669957153 0.004928451424328315 0.08077829945306131 0.025179558674837794 0.0060876019055995 0.03595179572860362 1.103993273458837e-07 6.95703357271969 -0.8510926857095951 down VQK(ub)VMVQPINLIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQKVMVQPINLIFR 14 1 P62304 P62304 SNRPE Small nuclear ribonucleoprotein E 1 27160800.0 10339000.0 14870000.0 1951800.0 True False 13554529.123018438 12651453.962806016 1749846.4589876335 1.0 0.9333746563959341 0.1290968091260379 23.692271659815354 -6.936678637666655 0.8117540172274639 1.0148205214820685 5.452761433734595e-20 0.995068403180398 0.02779375922110987 0.09284583607845608 0.09686499063908187 0.02440756048187288 0.07254121077182292 1.1569680403588627e-07 6.936678637666655 -1.0148205214820685 down VQK(ub)VMVQPINLIFR ddPTM_RPMI8226_Bortezomib_2h_R1 2 VQKVMVQPINLIFR 14 1 P62304 P62304 SNRPE Small nuclear ribonucleoprotein E 1 74935800.0 29679100.0 36265000.0 8991700.0 True False 28736953.216018 50745803.619476676 6636504.024782106 1.0 1.7658727853999125 0.23093972332052634 24.776403774957725 -6.771046254792565 1.5702796606103935 1.4387216252005957 0.2219410658186765 0.7345166361741078 0.3228737840110213 0.2647905750875289 1.2886673821858703 0.16204893188574573 0.3854012685841779 1.6941573535998083e-07 6.771046254792565 -1.2167805593819192 VQK(ub)VMVQPINLIFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQKVMVQPINLIFR 14 1 P62304 P62304 SNRPE Small nuclear ribonucleoprotein E 1 60552000.0 24049000.0 17478000.0 19025000.0 True False 36484091.2174038 14358914.343762698 15264700.411046265 1.0 0.3935664522435232 0.41839332985124844 25.12076418231369 -10.351772155936063 5.792115596928071 1.0001045178677384 0.4059798910473974 0.9986916175163406 0.010135530340915187 1.3682064937011465e-05 1.5312292405225042e-06 0.009815392483406921 0.003271228351277862 4.44864595724615e-11 10.351772155936063 -0.594124626820341 VQK(ub)VMVQPINLIFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQKVMVQPINLIFR 14 1 P62304 P62304 SNRPE Small nuclear ribonucleoprotein E 1 31586100.0 10339000.0 14470000.0 6777100.0 True False 14161607.700969314 13830667.554108871 5176488.558755744 1.0 0.9766311739564858 0.36552972431240494 23.755481721338246 -6.914976559297669 0.8611583038077418 1.0160751415304352 0.2775345790917205 0.992667874627208 0.025152236130528673 0.10121855692181389 0.12159779677851305 0.021113223847213626 0.060501731347089256 1.2162516450986406e-07 6.914976559297669 -0.7385405624387147 down VQK(ub)VMVQPINLIFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQKVMVQPINLIFR 14 1 P62304 P62304 SNRPE Small nuclear ribonucleoprotein E 1 55268400.0 19455000.0 30626000.0 5187400.0 True False 16177694.502634434 30461011.659214932 6272061.356172346 1.0 1.8829018964509776 0.3876980959895726 23.947502686898485 -6.746700851856991 1.6620179564890862 1.5212044045114828 0.38545068508265523 0.6346735978718209 0.37095669191485175 0.3058325114343711 1.6610781275665856 0.1763939319889283 0.42973684131766615 1.79183967340124e-07 6.746700851856991 -1.1357537194288274 VQK(ub)VMVQPINLIFR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VQKVMVQPINLIFR 14 1 P62304 P62304 SNRPE Small nuclear ribonucleoprotein E 1 89674600.0 39650100.0 30636800.0 19387700.0 True False 51327836.07031833 28931835.148088355 15859337.534601081 1.0 0.5636675411067826 0.30898122244768 25.61323810347758 -8.904691174092703 0.18569160529363646 1.40764362920567 2.882682608525064e-14 0.9996951199803564 0.004982223955729785 0.39604191842724606 0.05799254427379968 0.23962689196463835 0.14445111037263292 1.2453998982616506e-09 8.904691174092703 -1.4076436292056411 down VQLDTIQGELNAPTQFK(ub)GR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQLDTIQGELNAPTQFKGR 19 1 Q7Z3B4;Q7Z3B4-3;Q7Z3B4-2 Q7Z3B4 NUP54 Nucleoporin p54 1 18952400.0 2579600.0 4547800.0 11825000.0 True False 2497712.010001648 6363760.2564637 8727677.757604074 1.0 2.5478358717823117 3.494269044091402 21.25217571092402 -8.533802362998628 0.21661645154454787 1.9016074737879277e-14 4.452069290561197 0.9995836652717821 0.020977645177159703 0.17801138639659 0.0579030770371775 0.5308930545399383 0.4269502573997735 2.9254833922827853e-09 8.533802362998628 4.4520692905611785 VQLDTIQGELNAPTQFK(ub)GR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQLDTIQGELNAPTQFKGR 19 1 Q7Z3B4;Q7Z3B4-3;Q7Z3B4-2 Q7Z3B4 NUP54 Nucleoporin p54 1 15862300.0 2579600.0 2856700.0 10426000.0 True False 2145051.6956564263 2841310.3900894434 12606028.39562265 1.0 1.3245883051876515 5.876794681055445 21.032580986358298 -6.92126720078213 0.8152688242409917 0.9040733680358061 6.632721996859797 0.9945258458615429 0.16472463748186705 0.09743188489313437 0.10179121020479814 0.14288791685466298 0.43334552231495715 1.1987615351391575e-07 6.92126720078213 5.728648628823991 up VQLETIIK(ub)SLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQLETIIKSLK 11 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R2S2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 109380800.0 20588400.0 57479000.0 31313400.0 True False 26991591.77834924 48903357.25138721 28073389.747342627 1.0 1.8117996764686568 1.0400790726933389 24.6860067237512 -10.156032717169925 3.9048354646480177 0.9998028043653349 1.4259393739285002 0.2888513990165251 0.3150536180504389 222264477.60689282 424069294.7271355 608083.70097627 0.11529780924083775 6.981798053711966e-11 10.156032717169925 0.42613656956316537 VQLETIIK(ub)SLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQLETIIKSLK 11 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R2S2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 234770000.0 61404000.0 82710000.0 90656000.0 True False 59454763.63085023 115736534.32695198 66910473.978296295 1.0 1.946631813147062 1.1254013958198195 25.825289070335188 -10.183108669458798 4.331619129422939 0.9998809314193442 1.5360166041555652 0.36225385007904254 0.3352659146736478 235294387.40588507 106.3093203273063 364052.7025708181 0.1147704400287734 6.559811057299284e-11 10.183108669458798 0.536135672736221 VQLETIIK(ub)SLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQLETIIKSLK 11 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R2S2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 177273000.0 57119000.0 54575000.0 65579000.0 True False 86653698.95824744 44835664.85357881 52617281.9057032 1.0 0.5174120134811797 0.6072133392834842 26.368757998765133 -10.074233899912167 5.2786930422791425 1.0000056797435797 0.5623126763817952 0.9693945063993515 0.03666123774218758 2.4505779856870923e-06 4.297875048544142e-07 0.035497551348754854 0.011832363601947268 8.428806814980092e-11 10.074233899912167 -0.4376930033617845 VQLETIIK(ub)SLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQLETIIKSLK 11 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R2S2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 79026600.0 20588400.0 30178200.0 28260000.0 True False 28200487.860589672 28844827.338037882 21585570.03296942 1.0 1.022848522360093 0.7654325038516573 24.74921678527409 -6.885251178190694 1.0500311732804544 1.0154463639821283 0.7452446337794565 0.9776819867740912 0.01737971139805127 0.12308229674037233 0.24501472666905155 0.012683216290211624 0.031125513745128584 1.3024132979243147e-07 6.885251178190694 -0.2702017302026718 VQLETIIK(ub)SLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQLETIIKSLK 11 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R2S2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 136745000.0 61404000.0 45910000.0 29431000.0 True False 51060146.658430465 45662673.717578545 35584886.02643102 1.0 0.8942918637316379 0.6969209521562478 25.605694345769464 -6.961367066045881 0.4157239845487418 1.0091363319193432 0.5746831784300027 0.9998175750868502 0.0016964523775230436 0.07921640854314285 0.01935373459874303 0.0025470437304917597 0.01644975833163078 1.0930321441019403e-07 6.961367066045881 -0.43445315348934044 VQLETIIK(ub)SLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQLETIIKSLK 11 1 Q9UBC2-2;Q9UBC2;Q9UBC2-3;M0R165;Q9UBC2-4;M0R2S2 Q9UBC2-2 EPS15L1 Epidermal growth factor receptor substrate 15-like 1 1 121906000.0 57119000.0 53478000.0 11309000.0 True False 73941671.48381765 50501902.2890599 9250878.040139033 1.0 0.6829964927167272 0.12511048038944608 26.139884320857583 -7.365433017235789 0.5400428883229402 1.0069395931716272 1.7179507346960694e-22 0.9973331288018538 0.01867658365964277 0.10639704345867856 0.06357008841798557 0.01915350975586278 0.06225372641240001 4.310890412557259e-08 7.365433017235789 -1.0069395931716272 down VQLFEISLSHGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQLFEISLSHGR 12 0 Q8N5I2;F2Z3I4;Q5T371;Q5T370 Q8N5I2 ARRDC1 Arrestin domain-containing protein 1 0 3487660.0 799060.0 1211200.0 1477400.0 False True 1047575.3981080478 1030493.681220623 1324532.820221503 1.0 0.9836940453944653 1.2643794638683274 19.9986226534034 -6.893120575006845 1.0037625254169562 0.9860271865358042 1.2900481456587036 0.9828208716537474 0.01686144186507358 0.11664689024321127 0.2073609256482486 0.012744322274116208 0.032149614607833256 1.279026153438847e-07 6.893120575006845 0.3040209591228994 VQLFEISLSHGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQLFEISLSHGR 12 0 Q8N5I2;F2Z3I4;Q5T371;Q5T370 Q8N5I2 ARRDC1 Arrestin domain-containing protein 1 0 2729600.0 1419800.0 0.0 1309800.0 False True 1374729.2261592292 0.0 966724.0868422674 1.0 0.0 0.7032105438997162 20.39071605520045 -10.540489032603228 8.535153552119889 1.0000775966207056 0.35160527428966515 0.5313011905431226 0.2870845023832224 0.0004239521829074774 2.2824378196509314e-05 0.278000992206095 0.09265612472370537 2.8807857983897504e-11 10.540489032603228 -0.6484723223310405 VQLFEISLSHGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQLFEISLSHGR 12 0 Q8N5I2;F2Z3I4;Q5T371;Q5T370 Q8N5I2 ARRDC1 Arrestin domain-containing protein 1 0 25644800.0 7440500.0 8514800.0 9689500.0 False True 11287782.473412333 6995267.413563952 7774366.077941286 1.0 0.6197202532951771 0.688741663497974 23.428258755385404 -10.740206691582962 6.9167031345353545 1.005519159047679 0.6542309583966127 0.9709819721967192 0.02817787272069689 0.0024177878609817284 9.081267342414603e-05 0.027506157262442123 0.009094369314900942 1.818835023608271e-11 10.740206691582962 -0.35128820065106636 VQLFEISLSHGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQLFEISLSHGR 12 0 Q8N5I2;F2Z3I4;Q5T371;Q5T370 Q8N5I2 ARRDC1 Arrestin domain-containing protein 1 0 6928460.0 799060.0 1997200.0 4132200.0 False True 1094494.0757845568 1908957.1001427963 3156259.4653303707 1.0 1.7441456672795739 2.883761123209275 20.061832714926293 -6.9649105313895365 0.35959073080682485 0.9013390527991112 3.765595801745326 0.9999112817756517 0.007296648243640377 0.07799140288926479 0.014967507740747706 0.015302389912826023 0.09736134141973364 1.0841502358193965e-07 6.9649105313895365 2.8642567489462145 VQLFEISLSHGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQLFEISLSHGR 12 0 Q8N5I2;F2Z3I4;Q5T371;Q5T370 Q8N5I2 ARRDC1 Arrestin domain-containing protein 1 0 23670500.0 7440500.0 10125000.0 6105000.0 False True 9631873.924181875 9561534.849409686 4993952.642589873 1.0 0.9926972596063997 0.5184819363189552 23.199385077477853 -6.9102492342440724 0.8940374212837803 1.0145671528970845 0.45687006430819393 0.9910152470220991 0.02135460737183365 0.10425339324971222 0.1378755749709638 0.01750487724157874 0.048405132459996614 1.2295629429623298e-07 6.9102492342440724 -0.5576970885888906 VQLIK(ub)NGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQLIKNGK 8 1 P62266;D6RD47;D6RIX0;D6R9I7 P62266 RPS23 40S ribosomal protein S23 1 5754710.0 809710.0 1252400.0 3692600.0 True False 1061537.6512427938 1065546.801816965 3310525.173920351 1.0 1.0037767389310002 3.118613051590359 20.017724111832596 -6.9072884926642715 0.9140002158227967 0.9287739126934128 3.3766444208399204 0.989857505435613 0.10049189285210128 0.10623852614466062 0.1486949034551052 0.08118658899069822 0.2201172840553865 1.2379739533455867e-07 6.9072884926642715 2.4478705081465075 up VQLIK(ub)NGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQLIKNGK 8 1 P62266;D6RD47;D6RIX0;D6R9I7 P62266 RPS23 40S ribosomal protein S23 1 7277860.0 866460.0 1788900.0 4622500.0 True False 838954.7015762252 2503217.0989902616 3411728.5779725006 1.0 2.9837333222964553 4.066642181708448 19.678233390494512 -8.751547587762136 0.2559674102271461 6.580571594568188e-17 4.821814388137489 0.9991681870659469 0.036623340850069123 0.30003640677189264 0.07837642750706811 0.6949537403608425 0.42747975225988744 1.7719538728788255e-09 8.751547587762136 4.821814388137489 VQLIK(ub)NGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQLIKNGK 8 1 P62266;D6RD47;D6RIX0;D6R9I7 P62266 RPS23 40S ribosomal protein S23 1 5060510.0 809710.0 1058000.0 3192800.0 True False 1109081.6685899845 1011254.0616618653 2438726.397780073 1.0 0.9117940457419236 2.1988699902330127 20.080934173355487 -6.890478591015352 1.0195113261584672 0.9316355525650857 2.3106290128881812 0.9812041091779239 0.08048324485214936 0.11875711717355047 0.2195688629053979 0.060110587303015175 0.15012236195171766 1.2868306870831478e-07 6.890478591015352 1.3789934603230956 up VQLIK(ub)NGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQLIKNGK 8 1 P62266;D6RD47;D6RIX0;D6R9I7 P62266 RPS23 40S ribosomal protein S23 1 5635860.0 866460.0 2295300.0 2474100.0 True False 720499.8806863348 2282934.76331862 2991422.8710540943 1.0 3.1685428749050435 4.151871431546277 19.458638665928788 -9.073472494276444 0.2871991468914813 2.9414073570978347e-17 4.63760709727325 0.9987721911858614 0.046138067180850666 0.5202758238987044 0.10151761041514629 0.8999998471023768 0.354008643247697 8.443597171210708e-10 9.073472494276444 4.63760709727325 VQLPLNVYLALYAYKPQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQLPLNVYLALYAYKPQK 18 1 Q8TEJ3 Q8TEJ3 SH3RF3 SH3 domain-containing RING finger protein 3 0 79607000.0 18334000.0 28986000.0 32287000.0 False True 27814018.394938737 23813221.831348307 25905460.29810521 1.0 0.8561589876449335 0.9313814325663629 24.7293088554855 -10.189308743676577 4.547626054754628 1.000021853722646 0.8937702101042397 0.7267095794407294 0.030709434548484113 6.805705932072306e-06 1.213210488126861e-06 0.02974039749862243 0.00991142738080189 6.466827199971657e-11 10.189308743676577 -0.10625164361840622 VQLPLNVYLALYAYKPQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQLPLNVYLALYAYKPQK 18 1 Q8TEJ3 Q8TEJ3 SH3RF3 SH3 domain-containing RING finger protein 3 0 57197000.0 18334000.0 19937000.0 18926000.0 False True 23733724.417169604 18827488.423968494 15481662.197159026 1.0 0.7932799797046682 0.652306478538159 24.50043517757795 -7.756153481510411 0.07947630661356997 1.552102265241772 0.0003148079106627232 0.9999977193322159 0.00021556045583374245 0.13542371733982791 0.009918436086933342 0.08529402606205737 0.10312678175515855 1.7532607825517605e-08 7.756153481510411 -1.5517874573311092 VQLTMCLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQLTMCLR 8 0 O15397;F5GXT5 O15397 IPO8 Importin-8 0 11021200.0 2980400.0 3388600.0 4652200.0 False True 4521484.696426066 2783877.854747359 3732690.630868306 1.0 0.6156999396565094 0.8255453421790304 22.108365150030963 -10.089408556641272 5.112607166717177 1.0000061758233965 0.7206226409170889 0.7026745948161774 0.08566902684389073 6.0307150356478965e-06 1.0741938884915435e-06 0.08295051241210537 0.02764955952067511 8.139382224072177e-11 10.089408556641272 -0.2793835349063075 VQLTTCIHHIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQLTTCIHHIIK 12 0 O95373;E9PLB2 O95373 IPO7 Importin-7 0 85779000.0 29302000.0 23055000.0 33422000.0 False True 38415205.76097162 19615283.867686145 29963812.046462066 1.0 0.5106124900055728 0.7799987388562722 25.19517414530627 -10.109295244701652 5.343698496999149 1.0000061687426414 0.6453056144307026 0.6980233160830286 0.10997647556854591 8.082620381512804e-06 1.346950853259878e-06 0.10648611570422496 0.03549475486251843 7.775078012747768e-11 10.109295244701652 -0.3547005543119388 VQLTTCIHHIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQLTTCIHHIIK 12 0 O95373;E9PLB2 O95373 IPO7 Importin-7 0 48276000.0 11927000.0 14304000.0 22045000.0 False True 18094130.98049714 11751339.4423379 17687796.08733325 1.0 0.6494558625116701 0.9775432766789486 24.109018484260556 -10.517547174362333 8.788584243620194 1.0000107300694236 0.8134995700961887 0.3011114144033342 0.13394112595650084 2.8162043673590585e-05 1.545767861522426e-06 0.12969539317583362 0.043229312516816484 3.037056179925157e-11 10.517547174362333 -0.18651115997323497 VQLTTCIHHIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQLTTCIHHIIK 12 0 O95373;E9PLB2 O95373 IPO7 Importin-7 0 78908000.0 29302000.0 23702000.0 25904000.0 False True 40135741.25677552 22654767.26796744 19786008.709626332 1.0 0.564453690366139 0.4929772838389064 25.258384206829163 -13.999999999999998 0.25431676488278177 4.09616097340385 0.46539522499034836 0.9995509686148982 0.00474820054377843 14.173314204257233 0.15957481726666528 22.475705086659143 0.03221282394367097 1.0000000000000041e-14 13.999999999999998 -3.630765748413502 VQLTTCIHHIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQLTTCIHHIIK 12 0 O95373;E9PLB2 O95373 IPO7 Importin-7 0 43862000.0 11927000.0 19501000.0 12434000.0 False True 15439736.61631843 18415752.207243305 10171139.583613822 1.0 1.1927504118029766 0.658763801246702 23.880144806353005 -6.8090598060164975 1.4184595586752897 1.1051644396404823 0.6496194087952617 0.8573652144700623 0.08338604704314964 0.2080847102804525 0.8253397667659141 0.04622616452219692 0.10697800400553467 1.5521732478802283e-07 6.8090598060164975 -0.4555450308452206 VQLVVGDGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQLVVGDGR 9 0 A0A0A0MRJ6;P22061;P22061-2;F6S8N6;A0A3F2YNX8 A0A0A0MRJ6 PCMT1 Protein-L-isoaspartate O-methyltransferase;Protein-L-isoaspartate(D-aspartate) O-methyltransferase 0 22391200.0 8360900.0 6128800.0 7901500.0 False True 10961220.867070785 5214406.929875283 7083928.576540005 1.0 0.47571406443785597 0.6462718580757031 23.385905159661025 -10.809105151353998 8.197494488148465 1.0119567187541019 0.5609929612567796 0.8983080175527305 0.06962992767793942 0.01487273213075559 0.0003463404204004044 0.06589937558821408 0.022472962524523844 1.5520111916064198e-11 10.809105151353998 -0.4509637574973223 VQLVVGDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQLVVGDGR 9 0 A0A0A0MRJ6;P22061;P22061-2;F6S8N6;A0A3F2YNX8 A0A0A0MRJ6 PCMT1 Protein-L-isoaspartate O-methyltransferase;Protein-L-isoaspartate(D-aspartate) O-methyltransferase 0 25683600.0 8360900.0 4838700.0 12484000.0 False True 11452150.674826803 4624910.234558852 9535536.316050615 1.0 0.40384643599956804 0.8326415349224199 23.449115221183916 -9.744427300552273 5.938535799023962 1.0000000133512656 0.6182439854591121 0.51381825777344 0.1750548661013507 3.0973590716583446e-08 6.592229054373649e-09 0.16949615158200268 0.056498715089261645 1.8012446315498722e-10 9.744427300552273 -0.38175602789215357 VQNGSVHQK(ub)DGLNDDDFEPYLSPQAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQNGSVHQKDGLNDDDFEPYLSPQAR 26 1 Q9Y5A9;S4R3J8 Q9Y5A9 YTHDF2 YTH domain-containing family protein 2 1 16352100.0 2785900.0 5282200.0 8284000.0 True False 3652341.8786939764 4494116.349854334 7426851.14573909 1.0 1.2304752674088013 2.033449056087494 21.800390384923237 -6.94804916207366 0.5798643886304087 0.9903968490857729 2.3132346716031185 0.9990391733987207 0.013730444660661029 0.08427866725351611 0.039278028011774206 0.014388028343737532 0.06707455155404593 1.1270698648053871e-07 6.94804916207366 1.3228378225173456 up VQNGSVHQK(ub)DGLNDDDFEPYLSPQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQNGSVHQKDGLNDDDFEPYLSPQAR 26 1 Q9Y5A9;S4R3J8 Q9Y5A9 YTHDF2 YTH domain-containing family protein 2 1 30031700.0 4065100.0 7372600.0 18594000.0 True False 3936055.62562324 10316517.627601085 13723673.59195687 1.0 2.6210294286599556 3.4866564137502114 21.90831917878276 -8.900108076450024 0.23642509855552438 1.077299690852442e-15 4.16976944443039 0.9993101288087731 0.027070931070433145 0.3972694133282368 0.07648708451548872 0.7057780630127054 0.3815822018565624 1.2586121606091281e-09 8.900108076450024 4.169769444430389 VQNGSVHQK(ub)DGLNDDDFEPYLSPQAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQNGSVHQKDGLNDDDFEPYLSPQAR 26 1 Q9Y5A9;S4R3J8 Q9Y5A9 YTHDF2 YTH domain-containing family protein 2 1 55677000.0 8434000.0 20265000.0 26978000.0 True False 12794994.60799136 16648552.418832319 21645786.475122545 1.0 1.3011769781000255 1.691738616412019 23.609076203615018 -6.967563352902248 0.31092984826290404 0.9404876220842441 2.0648595236448943 0.9999566552659462 0.0018643940694384423 0.0771015432257682 0.011846103883035938 0.006153680230314429 0.03464332334683024 1.0775480544233245e-07 6.967563352902248 1.1243719015606501 VQNGSVHQK(ub)DGLNDDDFEPYLSPQAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQNGSVHQKDGLNDDDFEPYLSPQAR 26 1 Q9Y5A9;S4R3J8 Q9Y5A9 YTHDF2 YTH domain-containing family protein 2 1 12263300.0 2785900.0 2979200.0 6498200.0 True False 3815922.516116681 2847569.093103054 4963458.994629933 1.0 0.7462334680739053 1.3007232127137256 21.863600446446128 -6.782276699365331 1.5270578183422918 0.8567356000678847 1.3054286753752489 0.7753428950471394 0.10742279300673348 0.24705420640015832 1.1380585101580258 0.05539880110026379 0.1304682129857014 1.6509096292113197e-07 6.782276699365331 0.44869307530736413 VQNGSVHQK(ub)DGLNDDDFEPYLSPQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQNGSVHQKDGLNDDDFEPYLSPQAR 26 1 Q9Y5A9;S4R3J8 Q9Y5A9 YTHDF2 YTH domain-containing family protein 2 1 17842700.0 4065100.0 6271400.0 7506200.0 True False 3380310.7644646247 6237614.723424567 9075711.715252515 1.0 1.8452784841551346 2.6848749560722505 21.688724454217038 -6.971208498873184 0.2274770364670257 0.6475789707678548 3.906491990275348 0.9999903357620891 0.0021383318088696837 0.07591247436477766 0.0076119853132594366 0.021979956751007165 0.0838025797170468 1.068541763696923e-07 6.971208498873184 3.258913019507493 VQNGSVHQK(ub)DGLNDDDFEPYLSPQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQNGSVHQKDGLNDDDFEPYLSPQAR 26 1 Q9Y5A9;S4R3J8 Q9Y5A9 YTHDF2 YTH domain-containing family protein 2 1 67449000.0 8434000.0 21858000.0 37157000.0 True False 10917979.258994693 20641583.085273776 30394807.263015848 1.0 1.8906047168269136 2.7839224220888057 23.380202525707467 -6.971087567278885 0.2307374119203717 0.6400264947699412 4.060048023699391 0.9999896670198319 0.0023410569762856775 0.07595139937909025 0.007755793181024729 0.02282923411086372 0.08859768860027466 1.0688393462294546e-07 6.971087567278885 3.4200215289294498 VQNLLGHYLIHGFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQNLLGHYLIHGFR 14 0 E9PDU5;A0A087X295;Q9NNW5;V9GZ65;C9JFP6;V9GYU1;C9K020 E9PDU5 WDR6 WD repeat-containing protein 6 0 9477400.0 1458700.0 2965200.0 5053500.0 False True 1912369.8260708926 2522803.71825907 4530612.29659494 1.0 1.319202846576156 2.369108858982273 20.866930117038695 -6.949365899153697 0.5657639401148347 0.9866606984108757 2.7523265379758555 0.9991505655001194 0.017046058710314563 0.08374140549741955 0.037024127664926534 0.01814775331730656 0.08738908479970307 1.1236578776298734e-07 6.949365899153697 1.7656658395649798 up VQNLLGHYLIHGFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQNLLGHYLIHGFR 14 0 E9PDU5;A0A087X295;Q9NNW5;V9GZ65;C9JFP6;V9GYU1;C9K020 E9PDU5 WDR6 WD repeat-containing protein 6 0 16826200.0 5032900.0 1874700.0 9918600.0 False True 4873133.344370182 2623277.4864313495 7320621.108378154 1.0 0.5383143249018543 1.5022410820823318 22.216418269102416 -6.776475072188655 1.5496568301355207 0.7373789467561338 1.5090405004948768 0.754674147631216 0.1949701646581573 0.25610530678105475 1.2145210024369508 0.0991210864894539 0.23457761415475833 1.673111667586726e-07 6.776475072188655 0.771661553738743 VQNLLGHYLIHGFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQNLLGHYLIHGFR 14 0 E9PDU5;A0A087X295;Q9NNW5;V9GZ65;C9JFP6;V9GYU1;C9K020 E9PDU5 WDR6 WD repeat-containing protein 6 0 14172700.0 1458700.0 4447000.0 8267000.0 False True 1998020.8098852793 4250516.835737533 6314504.864209425 1.0 2.12736364641847 3.1603799284612983 20.930140178561587 -6.972170114202242 0.1996606224751711 0.3824248753251487 4.933829764601183 0.999994729615485 0.0020254051021617804 0.07560458854255976 0.006444064344274168 0.03363250973393029 0.10976159632111615 1.0661784147554696e-07 6.972170114202242 4.551404889276034 VQNLLGHYLIHGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQNLLGHYLIHGFR 14 0 E9PDU5;A0A087X295;Q9NNW5;V9GZ65;C9JFP6;V9GYU1;C9K020 E9PDU5 WDR6 WD repeat-containing protein 6 0 13648300.0 5032900.0 2276500.0 6338900.0 False True 4185079.3452741695 2264236.042650129 7664334.682237901 1.0 0.5410258338845895 1.831347520541645 21.996823544536692 -6.810564331551361 1.412402538859119 0.7500325925805358 1.8541610625331006 0.8612339478113146 0.19893450607906943 0.2060351723007669 0.8100080418274731 0.11075239269343237 0.2560991066216155 1.5468053604449884e-07 6.810564331551361 1.1041284699525649 VQNLLGHYLIHGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQNLLGHYLIHGFR 14 0 E9PDU5;A0A087X295;Q9NNW5;V9GZ65;C9JFP6;V9GYU1;C9K020 E9PDU5 WDR6 WD repeat-containing protein 6 0 17480600.0 3247400.0 8991400.0 5241800.0 False True 4203823.315823965 8491020.685924185 4287846.185409916 1.0 2.019832911141251 1.0199872504797414 22.00327060429002 -6.641583892233163 2.038451990805597 1.6661217176371204 1.0241416128017453 0.16068363693404175 0.4361869221785202 0.5294892541394061 4.206849183599413 0.17412336131569128 0.48309019394888786 2.2825279684333253e-07 6.641583892233163 -0.641980104835375 VQNMALYADVGGK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VQNMALYADVGGK 13 0 P51571 P51571 SSR4 Translocon-associated protein subunit delta 0 64075000.0 16123900.0 26222600.0 21728500.0 False True 21138589.044069707 22310290.294894196 19480243.254489608 1.0 1.0554294919297464 0.9215488892790914 24.33337574731542 -6.794252362828714 1.4791530756837485 1.0308089873062785 0.9199503701531347 0.8148566718408556 0.023633380742077714 0.22906612451105127 0.9899037877097091 0.012573022227910718 0.029349887666314384 1.6060077517708261e-07 6.794252362828714 -0.11085861715314371 VQNMALYADVGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQNMALYADVGGK 13 0 P51571 P51571 SSR4 Translocon-associated protein subunit delta 0 30660800.0 7870600.0 7086200.0 15704000.0 False True 7620752.111148624 9915756.614044817 11590651.290098442 1.0 1.3011519689163966 1.5209327269866362 22.861501957263055 -6.974559677729871 0.10134111936874393 0.4688422034042919 2.3588214575508557 0.9999997297952515 0.00011084679668100102 0.07484912153982923 0.0029774179002804834 0.019485752881849817 0.035679724946171 1.0603282254244199e-07 6.974559677729871 1.8899792541465639 VQNMALYADVGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQNMALYADVGGK 13 0 P51571 P51571 SSR4 Translocon-associated protein subunit delta 0 81111000.0 11778000.0 48372000.0 20961000.0 False True 17868087.08713803 39739638.66783903 16818049.16246733 1.0 2.224056692472961 0.9412338926069737 24.09088185552321 -6.656811626783069 1.9843013950473256 1.78997719861825 0.9466176104397654 0.22209446365497965 0.5215768708841915 0.49205275949279287 3.721018726895006 0.2126180666794491 0.5779763029522368 2.2038821794417147e-07 6.656811626783069 -0.8433595881784846 VQNMALYADVGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VQNMALYADVGGK 13 0 P51571 P51571 SSR4 Translocon-associated protein subunit delta 0 47894400.0 16123900.0 13086600.0 18683900.0 False True 22085341.56201362 12508390.740400922 14271147.626999227 1.0 0.5663661893241951 0.6461818843474596 24.39658580883831 -10.815136099838924 7.248543379298928 1.017996997423878 0.6062740368358274 0.9701003282869537 0.03258462104543278 0.009090386484565345 0.00023183722026975893 0.03026323384255886 0.010516641220953393 1.530607722432115e-11 10.815136099838924 -0.4117229605880507 VQNMALYADVGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQNMALYADVGGK 13 0 P51571 P51571 SSR4 Translocon-associated protein subunit delta 0 16816500.0 7870600.0 5831600.0 3114300.0 False True 6544752.626699287 5800184.013318031 3765485.7311037383 1.0 0.8862342618812219 0.5753442407803859 22.64190723269733 -6.953527663063067 0.5186736717355005 1.0053375012431909 0.4423984730974488 0.9994498252559288 0.0042099172933029675 0.08209940444441972 0.030333790501368967 0.004779430245914477 0.025676395127405435 1.1129415000027049e-07 6.953527663063067 -0.562939028145742 VQNMALYADVGGK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VQNMALYADVGGK 13 0 P51571 P51571 SSR4 Translocon-associated protein subunit delta 0 60364500.0 15769200.0 23694500.0 20900800.0 False True 20413540.257403236 22375880.24586052 17097068.86031813 1.0 1.0961293319881453 0.8375357064347355 24.283023070437313 -6.8060167764564214 1.4309711897930548 1.0526410716253252 0.8334018940400145 0.8492464450342392 0.04143692330814612 0.21227307292012537 0.8573628123089415 0.022773026062049142 0.05278588396788339 1.5630872606354292e-07 6.8060167764564214 -0.21923917758531064 VQPEAQAK(ub)VDVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQPEAQAKVDVFR 13 1 Q06323;Q06323-3;Q06323-2 Q06323 PSME1 Proteasome activator complex subunit 1 1 8917400.0 3023000.0 4069200.0 1825200.0 True False 3963182.274773644 3462091.221617366 1636345.8125546833 1.0 0.873563460266309 0.4128868417105905 21.918227890620667 -6.947021825117815 0.5906442038820169 1.0053146211493844 0.2579297560329121 0.9989462881013859 0.008189986055414815 0.08470432143900374 0.04108628131824678 0.008485228334444575 0.03860061819780388 1.1297391391198017e-07 6.947021825117815 -0.7473848651164723 down VQPFHQGRPLPASGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQPFHQGRPLPASGK 15 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 13357300.0 2113300.0 1767000.0 9477000.0 False True 2046214.4482619357 2472572.314783271 6994689.3960941825 1.0 1.2083642146518345 3.4183559802519747 20.96452592028786 -6.9252534870196385 0.7847777213269742 0.9598342916642656 3.821682576772228 0.9955202670121074 0.07323725974782433 0.09517820932687117 0.09031154520531472 0.06492636722863118 0.20543106505519454 1.1878087302934804e-07 6.9252534870196385 2.8618482851079623 up VQPFHQGRPLPASGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQPFHQGRPLPASGK 15 1 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 12771440.0 204190.0 6684650.0 5882600.0 False True 279684.5610272675 6389300.059818507 4493251.035949967 1.0 22.844664847966314 16.06542391702452 18.093441091696906 -9.770193960240038 8.913824417014048 1.0001554778397999 19.455044382495416 0.9080978135990667 2.7676135221553677 0.0 0.0 2.6797303492035494 0.8932434231179254 1.6974853692775726e-10 9.770193960240038 18.454888904655615 VQPFHQGRPLPASGK(ub)TLEFAGQDLSAYLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQPFHQGRPLPASGKTLEFAGQDLSAYLLK 30 2 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 173203000.0 35242000.0 15622000.0 122339000.0 True False 34123262.00049548 21859946.06765378 90294745.80867018 1.0 0.6406171270301289 2.6461346458424484 25.024252231354065 -6.860563974268162 1.1829650644750516 0.8047336014354262 2.7442654613480086 0.9543179601005046 0.18661463532657396 0.14621668330056903 0.3885027913979754 0.1230157081705454 0.28732415424904967 1.378592862740274e-07 6.860563974268162 1.9395318599125826 up VQPFHQGRPLPASGK(ub)TLEFAGQDLSAYLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQPFHQGRPLPASGKTLEFAGQDLSAYLLK 30 2 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 755156100.0 38210100.0 94796000.0 622150000.0 True False 57967515.23248879 77878913.15547144 499181779.80196744 1.0 1.343492348138859 8.61140550530607 25.788741310276002 -6.916757578984627 0.8484192654142905 0.8201434601428395 9.700287715624214 0.993231949805518 0.2887523129417185 0.10011756486584752 0.11577514016845208 0.24460857744383913 0.7114775212891725 1.211274072030478e-07 6.916757578984627 8.880144255481374 up VQPFHQGRPLPASGK(ub)TLEFAGQDLSAYLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQPFHQGRPLPASGKTLEFAGQDLSAYLLK 30 2 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 149303000.0 35242000.0 26667000.0 87394000.0 True False 29305284.48531703 26523339.57801496 105667681.33579949 1.0 0.905070196172437 3.6057551800509797 24.80465750678834 -6.898753717784407 0.9691258290256687 0.8838435343351344 3.8821581412650703 0.9859356305097297 0.14840055902646265 0.11232802502636038 0.18264439656381895 0.11511247482032973 0.29766942649861294 1.262543301946515e-07 6.898753717784407 2.998314606929936 up VQPFHQGRPLPASGK(ub)TLEFAGQDLSAYLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQPFHQGRPLPASGKTLEFAGQDLSAYLLK 30 2 Q9H568 Q9H568 ACTL8 Actin-like protein 8 1 484053100.0 38210100.0 86161000.0 359682000.0 True False 49463727.68367475 81366064.60839395 294223566.6489778 1.0 1.6449642681347771 5.94826917474893 25.55986763236845 -6.933631510570763 0.7163548335331774 0.9425505543369536 6.919383459753104 0.9972050981560717 0.11611968082437764 0.09079555624712826 0.06876044985311504 0.10817638082525032 0.38189835724660137 1.1651141842007811e-07 6.933631510570763 5.97683290541615 up VQPSDQVGK(ub)VIYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQPSDQVGKVIYK 13 1 P0DN79;P35520;P35520-2;H7C2H4;H7C1W6;H7C2W0 P0DN79 CBS Cystathionine beta-synthase 1 4361000.0 1187600.0 1804800.0 1368600.0 True False 1556955.1007347591 1535530.8750552982 1226990.4005382077 1.0 0.9862396637710681 0.7880705101638228 20.570295910092252 -6.920930628414492 0.817800396291022 1.0042275385990975 0.7554203194153132 0.9944354245306815 0.0072227095705373195 0.09762730309158861 0.10280130222529825 0.006253959470709795 0.018903375625854237 1.1996909192488734e-07 6.920930628414492 -0.24880721918378434 VQPSDQVGK(ub)VIYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQPSDQVGKVIYK 13 1 P0DN79;P35520;P35520-2;H7C2H4;H7C1W6;H7C2W0 P0DN79 CBS Cystathionine beta-synthase 1 7869900.0 2596900.0 1729700.0 3543300.0 True False 2514462.8309711907 2420378.230266336 2615203.433278521 1.0 0.962582624190744 1.0400644627021272 21.26181879684313 -6.775354335969602 1.5536442031223567 0.9786860857851881 1.0405947675752636 0.7507448133912692 0.015795407657438046 0.25784681910614277 1.2289152811214064 0.008009812813953802 0.018977066168125944 1.6774348594750385e-07 6.775354335969602 0.06190868179007547 VQPSDQVGK(ub)VIYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQPSDQVGKVIYK 13 1 P0DN79;P35520;P35520-2;H7C2H4;H7C1W6;H7C2W0 P0DN79 CBS Cystathionine beta-synthase 1 3615490.0 1187600.0 903890.0 1524000.0 True False 1626687.8136832512 863953.1510354861 1164062.5877652322 1.0 0.5311118358225527 0.7156029435847846 20.633505971615143 -10.13753523043138 5.252763882309745 1.0000111072273061 0.6233573897034085 0.8474931241804718 0.07531817935062521 9.797312847334121e-06 1.6085837986425836e-06 0.07292866282290596 0.024308837857505112 7.285590706274371e-11 10.13753523043138 -0.37665371752389765 VQPSDQVGK(ub)VIYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQPSDQVGKVIYK 13 1 P0DN79;P35520;P35520-2;H7C2H4;H7C1W6;H7C2W0 P0DN79 CBS Cystathionine beta-synthase 1 7436400.0 2596900.0 2738600.0 2100900.0 True False 2159437.4121763743 2723846.618230463 2540188.476535928 1.0 1.2613686337337522 1.176319564629482 21.042224072277406 -10.100764113830044 4.413681670965342 0.9999771402166252 1.2188440991351501 0.8982513612384722 0.034721137117123435 24170740.5751341 0.16826853808369685 5774.312635283416 0.01188596875589286 7.929318928951153e-11 10.100764113830044 0.21886695891852492 VQPTHVIHLAAMVGGLFR ddPTM_RPMI8226_Bortezomib_2h_R1 2 VQPTHVIHLAAMVGGLFR 18 0 Q13630;E9PKL9;E9PP14;A0A0J9YX13;E9PLH9 Q13630 TSTA3 GDP-L-fucose synthase 0 150380100.0 56987500.0 20723700.0 72668900.0 False True 55178463.005880326 28998781.48266782 53634735.06972975 1.0 0.525545292546069 0.9720229986111418 25.71760193524348 -10.60170611617651 9.481435966200866 1.0000420386817914 0.7487841455786054 0.29682318064542923 0.18227376023129313 0.0001620025460446034 6.805267381878308e-06 0.17651519499856821 0.05882860315220013 2.5020378992768703e-11 10.60170611617651 -0.251257893103186 VQPTHVIHLAAMVGGLFR ddPTM_RPMI8226_Bortezomib_8h_R1 2 VQPTHVIHLAAMVGGLFR 18 0 Q13630;E9PKL9;E9PP14;A0A0J9YX13;E9PLH9 Q13630 TSTA3 GDP-L-fucose synthase 0 523957700.0 172735500.0 154004200.0 197218000.0 False True 262052382.1565909 126520947.26969329 158237775.8562797 1.0 0.48280785020336114 0.6038402496250685 27.9652799827852 -9.941141727765658 6.955135468004902 1.0000000197290158 0.5433240499142822 0.9499560275532669 0.049411270154657384 1.5131361173802883e-08 2.2550121899068968e-09 0.047842258744693986 0.01594741886866109 1.1451391754675237e-10 9.941141727765658 -0.4566759698147336 VQPTHVIHLAAMVGGLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VQPTHVIHLAAMVGGLFR 18 0 Q13630;E9PKL9;E9PP14;A0A0J9YX13;E9PLH9 Q13630 TSTA3 GDP-L-fucose synthase 0 134472600.0 56987500.0 29770000.0 47715100.0 False True 47387631.22430631 29609623.101117685 57692106.800304346 1.0 0.6248386411416608 1.2174507420981324 25.498007210677756 -6.735609574512142 1.7025685576288463 0.7756559097840163 1.2174899306131906 0.5851652003876008 0.15765194050786802 0.32581693672400447 1.852626537453965 0.07330280296650633 0.18076671967111602 1.838190111460621e-07 6.735609574512142 0.4418340208291742 VQPTHVIHLAAMVGGLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VQPTHVIHLAAMVGGLFR 18 0 Q13630;E9PKL9;E9PP14;A0A0J9YX13;E9PLH9 Q13630 TSTA3 GDP-L-fucose synthase 0 419044500.0 172735500.0 137187000.0 109122000.0 False True 223609509.87574986 129552422.85293503 89262915.68627222 1.0 0.5793690211338584 0.3991910529023196 27.73640630487765 -13.999999999999998 0.11572641778095741 3.0128721141459516 0.09433045870385413 0.9997141429046134 0.0042562743601970284 11.98213455806569 0.10411903040928423 5.580933549669916 0.27053186612731867 1.0000000000000041e-14 13.999999999999998 -2.9185416554420973 VQQACEMVMDILR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQQACEMVMDILR 13 0 A0A087WTP3;Q92945;M0R0I5;M0QYH3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 9059700.0 1186400.0 5666200.0 2207100.0 False True 1555381.8891139438 4820825.046674613 1978730.4639981596 1.0 3.0994478464841184 1.2721830425358658 20.568837414560228 -6.612554018387009 2.144384006233383 2.4002260590703255 1.2788528998855877 0.058401712095117464 0.904551546916853 0.6055904423923043 5.28075240056569 0.3478988395916554 1.0037762169539728 2.440315518003839e-07 6.612554018387009 -1.1213731591847378 VQQACEMVMDILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQQACEMVMDILR 13 0 A0A087WTP3;Q92945;M0R0I5;M0QYH3 A0A087WTP3 KHSRP Far upstream element-binding protein 2 0 12670800.0 1186400.0 5005400.0 6479000.0 False True 1625044.1412544718 4784244.877355676 4948793.639193521 1.0 2.9440707214650934 3.0453287474229724 20.63204747608312 -10.471066809886226 0.5827781398124185 6.3208774259163244e-12 3.034643543812581 0.9997823566653211 0.013885553536536905 1.8605816238790285 0.28216669780396836 2.848234508524208 0.017990343991683724 3.3801283385042616e-11 10.471066809886226 3.0346435438062604 VQQEQSK(ub)AQLPDLLSEQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQQEQSKAQLPDLLSEQR 18 1 Q9H5N1;B4DHR0;Q9H5N1-2 Q9H5N1 RABEP2 Rab GTPase-binding effector protein 2 1 9636600.0 2967100.0 3474800.0 3194700.0 True False 2872911.0346084293 4862305.760842611 2357912.23105435 1.0 1.692466526902157 0.8207397314604723 21.45408188697132 -6.695019232227037 1.848364244647288 1.4320631499635825 0.8235366571866708 0.3941393961167208 0.29257156870669865 0.4059539546892746 2.6926680543098693 0.12644149760971665 0.3272207792121247 2.0182769846489407e-07 6.695019232227037 -0.6085264927769117 VQQEQSK(ub)AQLPDLLSEQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQQEQSKAQLPDLLSEQR 18 1 Q9H5N1;B4DHR0;Q9H5N1-2 Q9H5N1 RABEP2 Rab GTPase-binding effector protein 2 1 31767300.0 4413800.0 5547500.0 21806000.0 True False 6696057.292002879 4557505.282184665 17496034.54209066 1.0 0.6806251923244007 2.6128860281685804 22.67488044107964 -6.864461038202555 1.1630879680465451 0.8242235970121425 2.714705318650282 0.9588303241472692 0.17159726241945297 0.142271168179053 0.3632281691231019 0.11485006296382769 0.2695706087060478 1.3662776428590895e-07 6.864461038202555 1.8904817216381395 up VQQEQSK(ub)AQLPDLLSEQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQQEQSKAQLPDLLSEQR 18 1 Q9H5N1;B4DHR0;Q9H5N1-2 Q9H5N1 RABEP2 Rab GTPase-binding effector protein 2 1 11120900.0 2967100.0 6013100.0 2140700.0 True False 2467275.1148171006 5980706.236793099 2588310.4725215207 1.0 2.4240127097607633 1.0490562876338954 21.234487162405596 -6.638048680501881 2.0519864156028356 1.932633890186918 1.0548069624147143 0.14696864371463636 0.6095991769320919 0.53832571287773 4.329900881187959 0.24215540671380828 0.6748379865036611 2.3011838609560378e-07 6.638048680501881 -0.8778269277722037 VQQFK(ub)QDPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQQFKQDPR 9 1 Q93100-4;Q93100-2;Q93100-3;Q93100;H3BV13;I3NHZ9;H3BQ89 Q93100-4 PHKB Phosphorylase b kinase regulatory subunit beta 1 3545390.0 496890.0 1009300.0 2039200.0 True False 753818.4575248774 829182.5293031064 1636151.226186889 1.0 1.0999764214127667 2.170484431436057 19.52385759479541 -6.925102715910722 0.7859355447655673 0.9804348492935222 2.3651556768894477 0.9954855227284108 0.03559594815703323 0.09526084846940801 0.09072526025701727 0.031530389809355665 0.09959700382787233 1.1882211654884185e-07 6.925102715910722 1.3847208275959255 up VQQK(ub)DVSDEDVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQQKDVSDEDVAR 13 1 Q9H269-2;Q9H269;Q5JUA9 Q9H269-2 VPS16 Vacuolar protein sorting-associated protein 16 homolog 1 10763400.0 1960300.0 2105900.0 6697200.0 True False 2537646.993289933 1988704.8137651207 5478378.319074997 1.0 0.7836806376236215 2.15884176702314 21.27505996220261 -6.866672930109266 1.1514625751908558 0.8797898560426842 2.234474611965855 0.9612530737217387 0.11884630716577785 0.1400896744682182 0.34922160218784914 0.0802490604106185 0.18898228860106417 1.3593367862330945e-07 6.866672930109266 1.3546847559231707 up VQQLAK(ub)NTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQQLAKNTR 9 1 Q9NUV7;H0Y733 Q9NUV7 SPTLC3 Serine palmitoyltransferase 3 1 5380380.0 580280.0 1388500.0 3411600.0 True False 561859.3290292129 1942935.2909318423 2517999.6141938292 1.0 3.458045796425359 4.481548110172804 19.09984944702674 -9.137025588481054 0.31154014494097043 9.1113944472716e-20 4.8840389337695065 0.9985300862324946 0.05601399275712637 0.565523505321171 0.11357145066196861 0.9928185981520667 0.3373249528996815 7.294145321358485e-10 9.137025588481054 4.8840389337695065 VQQLAK(ub)NTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQQLAKNTR 9 1 Q9NUV7;H0Y733 Q9NUV7 SPTLC3 Serine palmitoyltransferase 3 1 3433820.0 244300.0 517320.0 2672200.0 True False 370620.96072234877 425000.20416039176 2144038.498733135 1.0 1.1467246842489873 5.784989857439133 18.49958495071578 -6.913640725563702 0.8705819543499975 0.8723934345654182 6.433525838673075 0.9922243450086382 0.19592554420230585 0.10205923917466292 0.12607485312105923 0.16335236748736737 0.4631502885223768 1.2199984374416383e-07 6.913640725563702 5.561132404107657 up VQQLAK(ub)NTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQQLAKNTR 9 1 Q9NUV7;H0Y733 Q9NUV7 SPTLC3 Serine palmitoyltransferase 3 1 4330980.0 580280.0 1239800.0 2510900.0 True False 482528.53076271975 1233120.9513189686 3035917.5809101174 1.0 2.5555399788895543 6.29168512815465 18.880254722461018 -6.956314324587058 0.4845930817517262 0.9140856102003546 8.090124152630432 0.9996081405929627 0.04395816631424749 0.08104495690839186 0.026203096647017334 0.05317914451696909 0.30816199412072826 1.1058231447042405e-07 6.956314324587058 7.176038542430078 VQQLK(ub)ETGHVSGPDGQNPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQQLKETGHVSGPDGQNPEK 20 1 Q9NVI1 Q9NVI1 FANCI Fanconi anemia group I protein 1 4762970.0 2319900.0 1960600.0 482470.0 True False 3041411.3659435553 1668086.1223589415 432548.6325790367 1.0 0.5484579103759091 0.14221970675277087 21.536309530536585 -7.857011181738454 0.393155970150976 1.0561449418282027 9.150576338527012e-18 0.9979725142658841 0.01577542714214321 0.10935545489950681 0.07431282273296382 0.03767551071441924 0.08044649086850146 1.3899168446967059e-08 7.857011181738454 -1.0561449418282027 down VQQLK(ub)ETGHVSGPDGQNPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQQLKETGHVSGPDGQNPEK 20 1 Q9NVI1 Q9NVI1 FANCI Fanconi anemia group I protein 1 9367400.0 1958700.0 2110200.0 5298500.0 True False 1896522.1406381729 2952813.864547625 3910663.8984071976 1.0 1.556962505881431 2.0620185837067386 20.85492478356241 -6.972289926928016 0.19591633012873283 0.6830720170739025 2.949792619938724 0.9999951684640676 0.0009533754673093663 0.07556643067482127 0.0062944224988257715 0.01696214834546625 0.05418511375785039 1.065884319093783e-07 6.972289926928016 2.2667206028648215 VQQLK(ub)ETGHVSGPDGQNPEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQQLKETGHVSGPDGQNPEK 20 1 Q9NVI1 Q9NVI1 FANCI Fanconi anemia group I protein 1 50025000.0 8264000.0 6745100.0 35015900.0 True False 12537092.179326601 5541384.2052931655 28094992.016985796 1.0 0.44199915945667134 2.2409496249308782 23.579699436200944 -6.8233948069930195 1.3571655853070153 0.7002302685577915 2.283142129218482 0.8920033071125912 0.24708025975312808 0.18910799660646566 0.6834854261177867 0.14303063266090793 0.3293951723182086 1.5017761156822155e-07 6.8233948069930195 1.5829118606606905 up VQQLK(ub)ETGHVSGPDGQNPEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQQLKETGHVSGPDGQNPEK 20 1 Q9NVI1 Q9NVI1 FANCI Fanconi anemia group I protein 1 12844800.0 1958700.0 3591300.0 7294800.0 True False 1628745.8351225941 3571952.954082759 8820108.952655677 1.0 2.1930695858472613 5.415276443050303 20.635330058996686 -6.953786089551106 0.5156079695379618 0.9433279612643589 6.807739447969774 0.9994658758650283 0.04309995877282355 0.08200015613569393 0.029939348193695085 0.04917533937139324 0.2660490503824767 1.1122794422973645e-07 6.953786089551106 5.864411486705415 VQQLK(ub)ETGHVSGPDGQNPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQQLKETGHVSGPDGQNPEK 20 1 Q9NVI1 Q9NVI1 FANCI Fanconi anemia group I protein 1 74586000.0 8264000.0 2091000.0 64231000.0 True False 10697910.907793704 1974634.011863277 52541617.065714955 1.0 0.18458127281885525 4.9113904124437076 23.350825758293393 -6.862440278869608 1.173439405522977 0.5544357398766161 5.151081843798766 0.9565327886150492 0.43012677675483374 0.14430359955402722 0.3762062920426069 0.28561112998416144 0.6685976309811255 1.3726497051876173e-07 6.862440278869608 4.596646103922151 up VQQLLHICSEHFDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQQLLHICSEHFDSK 15 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 34765500.0 11302000.0 7354500.0 16109000.0 False True 15480654.82506576 7029553.8719207775 12304385.975269094 1.0 0.4540863388116347 0.7948233530371236 23.883963162366616 -10.402485768174289 6.457660257836866 1.000052013760546 0.6244548459243887 0.6182713868049624 0.13910530355531686 0.00010418351675264004 9.639800243072212e-06 0.13470670464668 0.04489604366990577 3.958350361332548e-11 10.402485768174289 -0.37559716783615726 VQQLPK(ub)YTSQIVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQQLPKYTSQIVGR 14 1 Q9UNS2;Q9UNS2-2;H7C3P9;C9JLV5;K7ES36 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 8254000.0 2596500.0 3852800.0 1804700.0 True False 2514075.5287522417 5391243.132086569 1331994.9301605136 1.0 2.14442369389049 0.5298150015491359 21.261596561691785 -6.7163175189028665 1.772647711683635 1.6989742046778706 0.5328469732715647 0.49507721542026883 0.48180673659696166 0.3625063233449938 2.2241193927039054 0.21598910269412813 0.5445592215892353 1.9216862429094511e-07 6.7163175189028665 -1.166127231406306 VQQLVAK(ub)ELGQTGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQQLVAKELGQTGTR 15 1 Q9Y679;Q9Y679-3 Q9Y679 AUP1 Ancient ubiquitous protein 1 1 180737300.0 30765700.0 62396500.0 87575100.0 True False 40334130.63546261 53087185.41965203 78513668.73167726 1.0 1.3161851906379425 1.9465814062357998 25.26549782453362 -6.960105901356096 0.4339381594556963 0.9759808824084412 2.3111182555862997 0.9997741082114564 0.005913776695304805 0.07966330777615045 0.020991641413803115 0.008253192080180553 0.05229633104398208 1.0962108559481806e-07 6.960105901356096 1.3351373731778584 VQQLVAK(ub)ELGQTGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQQLVAKELGQTGTR 15 1 Q9Y679;Q9Y679-3 Q9Y679 AUP1 Ancient ubiquitous protein 1 1 279165200.0 31273500.0 42100700.0 205791000.0 True False 30280739.860748444 58911729.0622502 151888163.50233388 1.0 1.9455181522369211 5.015999087235635 24.851897119878398 -6.949656782981934 0.562598378749292 0.9603750683103288 6.148541541692537 0.9991740779759339 0.0492676647722568 0.08362384196591614 0.03653490317354738 0.05264791713986763 0.2553867944703545 1.1229055206872002e-07 6.949656782981934 5.188166473382208 VQQLVAK(ub)ELGQTGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQQLVAKELGQTGTR 15 1 Q9Y679;Q9Y679-3 Q9Y679 AUP1 Ancient ubiquitous protein 1 1 483345800.0 29814800.0 181350000.0 272181000.0 True False 45231231.35384644 148986675.60598284 218384306.04883003 1.0 3.293889446441371 4.828175123962411 25.430815935969203 -8.213746720773676 0.2514258631714075 2.8687617509084477e-16 6.116717976435767 0.9994512242779091 0.036850631395369704 0.09212449379433717 0.05655482743104164 0.48412525462770445 0.5438909365721348 6.112984283604979e-09 8.213746720773676 6.116717976435767 VQQLVAK(ub)ELGQTGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQQLVAKELGQTGTR 15 1 Q9Y679;Q9Y679-3 Q9Y679 AUP1 Ancient ubiquitous protein 1 1 184599500.0 30765700.0 29978800.0 123855000.0 True False 42140610.70178075 28654237.489365496 94602999.87379433 1.0 0.6799673049862717 2.244936613360391 25.328707886056513 -6.853431305495708 1.2184509012116376 0.8285833099275308 2.3117517758434696 0.9451465695153941 0.1581057289853257 0.15372352513178927 0.43745799447052525 0.1014410097321634 0.23530965795051342 1.401421237131907e-07 6.853431305495708 1.4831684659159388 up VQQLVAK(ub)ELGQTGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQQLVAKELGQTGTR 15 1 Q9Y679;Q9Y679-3 Q9Y679 AUP1 Ancient ubiquitous protein 1 1 165328600.0 31273500.0 58088000.0 75967100.0 True False 26005300.90095804 57775068.41443469 91851469.37781547 1.0 2.2216650610763073 3.5320287093633147 24.632302395312674 -6.97023292498573 0.2525595028176412 0.597028806953273 5.195169389470629 0.9999841432902317 0.0041170668385429356 0.07622718675158578 0.008759242903986022 0.028726374154052683 0.12506749907643203 1.0709447718007297e-07 6.97023292498573 4.598140582517356 VQQLVAK(ub)ELGQTGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQQLVAKELGQTGTR 15 1 Q9Y679;Q9Y679-3 Q9Y679 AUP1 Ancient ubiquitous protein 1 1 276905700.0 29814800.0 154886000.0 92204900.0 True False 38595846.33757114 146266457.9442637 75424554.30216788 1.0 3.7896942760361383 1.9542142862338485 25.201942258061653 -10.20824656174866 6.21678821370258 0.9999776061217314 2.871954281134997 0.5810380007815743 0.7493315680174278 0.00023258367156754823 2.9622056123767074e-05 0.7255457767832195 0.24184572364324683 6.19089499971782e-11 10.20824656174866 1.8719766750132658 VQQMHRPK(ub)LIGEELAQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQQMHRPKLIGEELAQLK 18 2 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 10535700.0 2678600.0 3122600.0 4734500.0 True False 3511670.5395992966 2656720.2517994666 4244619.3565308675 1.0 0.7565402909643724 1.2087179901037086 21.743726068758352 -6.760473172895241 1.6107894853596196 0.8586677530436542 1.2104030232632126 0.692862065846803 0.10240640214773783 0.282121287733872 1.4428328198852143 0.05015987017772943 0.12048097628972579 1.7359084895633277e-07 6.760473172895241 0.3517352702195584 VQQMHRPK(ub)LIGEELAQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQQMHRPKLIGEELAQLK 18 2 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 18841700.0 4580200.0 6370600.0 7890900.0 True False 4434804.058074724 8914413.802240115 5824036.568074247 1.0 2.010103194076655 1.3132567959727692 22.08043893299624 -10.507548123775678 5.021871034207867 0.9977735231140561 1.661679995024732 0.5458994485940247 0.2844863507418812 0.007110751962037553 0.0006972900842262187 0.2761949331330423 0.0918175748872091 3.107791512114336e-11 10.507548123775678 0.663906471910676 VQQMHRPK(ub)LIGEELAQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQQMHRPKLIGEELAQLK 18 2 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 39789100.0 5639100.0 20069000.0 14081000.0 True False 8554926.973431826 16487530.150187312 11297884.178078445 1.0 1.9272555103498805 1.3206289443691506 23.028324108957925 -10.478839971513725 5.1388605521110815 0.9986908914266303 1.623942227359529 0.5851547669780004 0.24765425851164338 0.003721303832580059 0.00037739713023900927 0.24023513629596135 0.07993006823607174 3.3201677629369304e-11 10.478839971513725 0.6252513359328987 VQQMHRPK(ub)LIGEELAQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQQMHRPKLIGEELAQLK 18 2 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 10410800.0 2678600.0 3522800.0 4209400.0 True False 3668950.8064432098 3367151.0476582446 3215226.4153142776 1.0 0.917742217133312 0.8763340216139921 21.806936130281244 -13.999999992820658 0.08877933240333165 1.4234869047516672 0.7705142197191565 0.9998480868961506 0.0006334492018534121 12.174777127769076 0.08627164628642034 0.9771992824877278 0.09518402829064805 1.000000016531045e-14 13.999999992820658 -0.6529726850325107 VQQMHRPK(ub)LIGEELAQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQQMHRPKLIGEELAQLK 18 2 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 12118100.0 4580200.0 5853300.0 1684600.0 True False 3808639.2372637503 5821767.111110921 2036842.0712896483 1.0 1.5285688006757676 0.534795223281106 21.860844208430517 -6.7622081946906105 1.604181682467498 1.3061755604048468 0.5307647512104343 0.6999250121202456 0.22239283339950833 0.2792146798827207 1.416634173898694 0.10935803473962193 0.2622322953651631 1.7289873082190152e-07 6.7622081946906105 -0.7754108091944125 VQQMHRPK(ub)LIGEELAQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQQMHRPKLIGEELAQLK 18 2 P54252-1;P54252;P54252-4;P54252-3;A0A2R8Y3X7;G3V3R7;C9JQV6;G3V328;G3V4U9;A0A087X1A8;A0A0A0MS38;D3VVH9;A0A087WXY4;S4R399;G3V2G1;G3V2G2;G3V3T6;F5H211;P54252-5;E9PJN5;G3V526;A0A2R8Y888 P54252-1 ATXN3 Ataxin-3 1 30069900.0 5639100.0 19472000.0 4958800.0 True False 7299926.113279217 18388366.08273633 4056349.281584707 1.0 2.518979753683568 0.5556699093441296 22.799450431050374 -6.700134931934103 1.8304460479739504 1.9431006669420228 0.5615054505967207 0.41820436413330253 0.6411639838082595 0.3952351232221174 2.5746383187396584 0.2794382367755896 0.7185063250600138 1.9946424987019265e-07 6.700134931934103 -1.381595216345302 VQRPPSAASAAPSSSK(ub)QPAADTEASEQQALHTVQYGLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQRPPSAASAAPSSSKQPAADTEASEQQALHTVQYGLLK 39 2 Q5SRE5;Q5SRE5-2 Q5SRE5 NUP188 Nucleoporin NUP188 homolog 1 45716800.0 6122800.0 15214000.0 24380000.0 True False 9288735.236638542 12498942.832475455 19561282.313866373 1.0 1.3456022282963294 2.105914509944124 23.147050740523262 -6.958139586198638 0.4609110558224364 0.9780387208929028 2.504174220553147 0.9996948350826427 0.008069751598686574 0.0803726013187915 0.023638982263784514 0.010341978125489424 0.06280322444437436 1.1011853216736396e-07 6.958139586198638 1.5261354996602443 up VQSGNINAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQSGNINAAK 10 0 P49368;P49368-2;E9PRC8;Q5SZX6;Q5SZX9;E9PM09;Q5SZW8 P49368 CCT3 T-complex protein 1 subunit gamma 0 3881540.0 1326600.0 823840.0 1731100.0 False True 1284487.809144126 1152803.6082688447 1277672.978113185 1.0 0.8974811594646238 0.9946945148233972 20.29276176725401 -10.483152919870356 5.817949556769408 1.0000530510517027 0.9460878371525312 0.29081647662049914 0.039687186135475346 2.7336661970350386e-05 2.4284775561732475e-06 0.03846474894778464 0.012808984246710809 3.287358589782872e-11 10.483152919870356 -0.05396521389917153 VQSSIAFLCGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQSSIAFLCGK 11 0 P11717 P11717 IGF2R Cation-independent mannose-6-phosphate receptor 0 5249900.0 1167600.0 2090900.0 1991400.0 False True 1530734.9070544834 1778945.8702643637 1785349.0308576573 1.0 1.1621515012599406 1.1663345642865852 20.545793027607864 VQTDAFVSNELDDPDDLQCK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQTDAFVSNELDDPDDLQCKR 21 1 A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2 A0A087WTA5 EIF2B4 Translation initiation factor eIF-2B subunit delta 1 5867300.0 1655600.0 1508100.0 2703600.0 True False 2267720.0609077075 1441467.1553802069 2065065.362389814 1.0 0.6356459865699765 0.9106350461807988 21.11281112685878 -10.324888773177175 5.687124536512662 1.0000328333590751 0.7731405163753862 0.4757393321674048 0.11226381348238909 4.674256593223453e-05 5.548533266403097e-06 0.10871468242951644 0.03623298999991825 4.732724528821097e-11 10.324888773177175 -0.22689231698368895 VQTDAFVSNELDDPDDLQCK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQTDAFVSNELDDPDDLQCKR 21 1 A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2 A0A087WTA5 EIF2B4 Translation initiation factor eIF-2B subunit delta 1 42266000.0 4943600.0 7647400.0 29675000.0 True False 6399587.652924607 7221815.467395118 24274454.491212826 1.0 1.1284813739670796 3.793127902564069 22.609547519710905 -6.916944725079468 0.847082108442175 0.9344849067869985 4.194008728292238 0.9932890887773789 0.10547044802469285 0.10000326596073503 0.11517783633108444 0.0894325777015281 0.26054306521391624 1.2107522224854186e-07 6.916944725079468 3.2595238215052396 up VQTEVLQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQTEVLQKR 9 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 4550300.0 1199100.0 1223700.0 2127500.0 True False 1572031.712100919 1041128.7299452397 1907366.7084210417 1.0 0.6622822694548816 1.213313124499231 20.5841988902472 -6.740864785163179 1.683616044630745 0.7992616415718907 1.2136926394546157 0.6088019475185698 0.14189171231125514 0.3162439363621512 1.7604581270868178 0.06666462548743145 0.16342853796511425 1.8160810000807253e-07 6.740864785163179 0.41443099788272497 VQTEVLQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQTEVLQKR 9 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 9721400.0 1420600.0 1701300.0 6599500.0 True False 1375503.8305971245 2380637.962162297 4870892.96924381 1.0 1.7307388821511538 3.5411700504892742 20.391528726699693 -6.955655252429524 0.4928717686166297 0.9613919055088738 4.387661643463224 0.9995735651589384 0.02205835243663865 0.08129133833197333 0.027156634201660774 0.026229238834076695 0.1493208723336767 1.1075025824396249e-07 6.955655252429524 3.4262697379543496 VQTEVLQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQTEVLQKR 9 1 H7C2Q8;Q99848 H7C2Q8 EBNA1BP2 Probable rRNA-processing protein EBP2 1 7138600.0 1420600.0 3065900.0 2652100.0 True False 1181291.8432507054 3049383.3881665003 3206641.8480750816 1.0 2.5813971421110797 2.7145212814226944 20.17193400213397 -10.525463487462325 0.49050083300513025 5.061127738962851e-18 2.7107952080527387 0.9995922494285202 0.015725252653111126 1.957068311866951 0.23320216516409428 2.4808642038473447 0.02751379186093572 2.982198260411563e-11 10.525463487462325 2.7107952080527387 VQTFSIHFGFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQTFSIHFGFK 11 0 O75419-2;O75419;O75419-3;A0A5F9ZI22;A0A5K1VW85;A0A5F9ZH29 O75419-2 CDC45 Cell division control protein 45 homolog 0 21898500.0 7445300.0 6148500.0 8304700.0 False True 11295064.424339345 5051252.13655023 6663272.404920692 1.0 0.44720879375114153 0.5899277909882688 23.42918916375261 -10.319624004031445 8.630920373435094 1.0000006460463018 0.5185682923698142 0.938164957183727 0.05826478663877398 7.243503237303924e-07 5.707600671428739e-08 0.05641471272919949 0.018804879026858342 4.7904465183870963e-11 10.319624004031445 -0.4814323536764876 VQTFSIHFGFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQTFSIHFGFK 11 0 O75419-2;O75419;O75419-3;A0A5F9ZI22;A0A5K1VW85;A0A5F9ZH29 O75419-2 CDC45 Cell division control protein 45 homolog 0 20341400.0 7445300.0 6649200.0 6246900.0 False True 9638087.618804025 6279166.174883445 5110028.298606821 1.0 0.6514950292247517 0.5301911022926472 23.20031548584506 -13.999999999999996 0.1471696379551625 2.6782563081947175 0.39229007386884956 0.999575959706418 0.004100620031747699 11.948238246793208 0.12066600233485907 5.7395858625970435 0.12397142017930587 1.0000000000000082e-14 13.999999999999996 -2.2859662343258678 VQTLEAWVIHGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQTLEAWVIHGGR 13 0 H0Y950;P28907 H0Y950 CD38 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 0 11561700.0 4519200.0 2250100.0 4792400.0 False True 5924714.963995058 1914393.8508211044 4296528.419946891 1.0 0.32311999184011736 0.7251873627773184 22.498314317440983 -10.815174366909686 6.944973652294289 1.024766096761025 0.5241536773091814 0.6512714366408324 0.1641433168364122 0.05724371572107095 0.0015234173695496392 0.14453847286972224 0.05297702770822268 1.530472861649715e-11 10.815174366909686 -0.5006124194518436 VQTLEAWVIHGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQTLEAWVIHGGR 13 0 H0Y950;P28907 H0Y950 CD38 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 0 9457000.0 4519200.0 2409900.0 2527900.0 False True 6190070.366787939 2303422.6495264005 1930862.0837347307 1.0 0.37211574554711546 0.3119289393048799 22.561524378963874 -13.999999999999998 0.3316269050218623 7.902330050359446 0.30147184968315166 0.9997182090016634 0.00522307919587661 18.96154985725115 0.18423644087965887 91.36166050107406 0.019170564361079393 1.0000000000000041e-14 13.999999999999998 -7.600858200676294 VQTLQFHPFEAQTLISGSYDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQTLQFHPFEAQTLISGSYDK 21 0 Q13610;B4DJV5 Q13610 PWP1 Periodic tryptophan protein 1 homolog 0 15470200.0 5373900.0 3133000.0 6963300.0 False True 5203308.486024141 4384023.238379168 5139402.83547775 1.0 0.8425453247975712 0.9877182660382257 22.310997811534836 -10.426307520560924 6.835513571220437 1.000010168626257 0.9151317954213761 0.31303456565053567 0.059266605083108034 9.185414546554674e-06 7.709033183483472e-07 0.0573915179239666 0.01912821453942743 3.747075807476641e-11 10.426307520560924 -0.0848783732048809 VQTLQFHPFEAQTLISGSYDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQTLQFHPFEAQTLISGSYDK 21 0 Q13610;B4DJV5 Q13610 PWP1 Periodic tryptophan protein 1 homolog 0 9321500.0 2016300.0 1311500.0 5993700.0 False True 2761780.598458691 1253553.5934494657 4578111.50412629 1.0 0.4538932579036349 1.6576666179352793 21.397167282805672 -6.783351094280239 1.522672745000755 0.6921287602645617 1.6682487043250172 0.7791202999184876 0.23129582099218485 0.24539854978746709 1.1239645915817056 0.11961232844586804 0.2814715714009833 1.646830515174125e-07 6.783351094280239 0.9761199440604554 VQTLQFHPFEAQTLISGSYDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQTLQFHPFEAQTLISGSYDK 21 0 Q13610;B4DJV5 Q13610 PWP1 Periodic tryptophan protein 1 homolog 0 15816700.0 3240000.0 7103600.0 5473100.0 False True 4194243.869948162 6708278.415433743 4477051.958748337 1.0 1.5994011372344576 1.0674276693414277 21.99997931720032 -10.050004449945959 4.435996396405531 0.9999809477080063 1.3334144029931658 0.3437261657678711 0.21717725895045564 32942062.789105177 37316068.49928339 5189.0063061477285 0.07434555200656244 8.912418060854295e-11 10.050004449945959 0.33343345528515955 VQVEYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQVEYK 6 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 54040300.0 5211300.0 27146000.0 21683000.0 False True 6832064.766300993 23095922.614279255 19439451.158022754 1.0 3.3805186871470214 2.8453259480073156 22.703890220743112 -9.98718685632141 5.852371161776305 0.9999975023885508 3.112922317577739 0.9540903348665163 0.21849152082448034 7.120308130695442e-06 1.2324392823433518e-06 0.2115537573042175 0.07051783511976638 1.029942889512147e-10 9.98718685632141 2.112924815189188 VQVEYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQVEYK 6 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 29996700.0 9329300.0 5220400.0 15447000.0 False True 9033146.478100635 7304932.944026366 11400967.299933195 1.0 0.8086808911751806 1.2621258082743314 23.10679717249694 -6.79208082685192 1.4879545746048308 0.8933582603095529 1.2672316346110137 0.8079935737574496 0.08144503442425571 0.23227435808571922 1.0158650595181489 0.043078083544408154 0.10070799707102958 1.6140581353751027e-07 6.79208082685192 0.37387337430146084 VQVEYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQVEYK 6 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 79296800.0 1708300.0 73583000.0 4005500.0 False True 2591615.99345881 60451538.74339694 3213811.169326981 1.0 23.325808644481086 1.2400800031480668 21.305420535473118 -4.460357698862605 9.453943245086506 9.999999999999998 12.563700374846615 0.0 10.572186377165531 0.0 0.0 3.123031939179644 0.0 3.464513844386782e-05 4.460357698862605 2.5637003748466167 VQVEYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQVEYK 6 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 43755300.0 5211300.0 16943000.0 21601000.0 False True 7138058.4400871815 16194402.236991478 16499288.686559554 1.0 2.268740494760321 2.311453292943065 22.767100282266004 -10.809469962733901 0.6084094224355655 7.722549885488646e-08 2.306111793879591 0.9998996398153628 0.0060950188120714125 2.4642900824331377 0.300095766052938 3.5887828169157783 0.007345021928313429 1.550708035265256e-11 10.809469962733901 2.306111716654092 VQVEYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQVEYK 6 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 13462100.0 9329300.0 2702500.0 1430300.0 False True 7757726.308066179 2687941.096095748 1729369.1170400002 1.0 0.34648568270588925 0.22292216151552938 22.887202447931216 -13.999999999999998 0.23421309616287345 5.207513955107775 0.1652031912710957 0.9995158281896691 0.007502145639827001 13.42616439630425 0.15320609154225553 26.333079754250605 0.06250119131205842 1.0000000000000041e-14 13.999999999999998 -5.042310763836679 VQVEYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQVEYK 6 0 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 6289500.0 1708300.0 2762400.0 1818800.0 False True 2211428.025627294 2608670.0116552394 1487797.0624639555 1.0 1.1796314333654443 0.6727766154821732 21.076546857565567 -6.8109017258276445 1.4106989467599294 1.097794022296447 0.6637219565641513 0.8621767020332406 0.07789716153450649 0.2055748414988785 0.8061402354941516 0.043416314757458274 0.1003923492828492 1.5456041464547658e-07 6.8109017258276445 -0.43407206573229573 VQVEYK(ub)GETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQVEYKGETK 10 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 235850000.0 74723000.0 91427000.0 69700000.0 True False 97962576.61856139 77786447.9796547 62488112.60961057 1.0 0.7940424870870145 0.6378773891679231 26.54572738447862 -6.974189888315997 0.12188116441775722 1.2730758788054326 0.15482614591250968 0.9999994081027329 0.00011394903681306199 0.07496506344573597 0.003634864776152858 0.010764097103496536 0.022273083653005427 1.0612314492666448e-07 6.974189888315997 -1.1182497328929228 VQVEYK(ub)GETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQVEYKGETK 10 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 340128000.0 86858000.0 138222000.0 115048000.0 True False 84100740.33366549 193414765.4182079 84913477.43398167 1.0 2.2997986064194498 1.0096638519125003 26.325615164703926 -6.64445757426246 2.028194003056062 1.847117989250544 1.0150545977972085 0.1718741293458036 0.5555326428811536 0.522298578613445 4.111516684814095 0.22262485855182437 0.615267657432178 2.267474573356823e-07 6.64445757426246 -0.8320633914533355 VQVEYK(ub)GETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQVEYKGETK 10 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 526433000.0 160192000.0 164757000.0 201484000.0 True False 243022975.6039069 135354826.0976836 161660599.08642575 1.0 0.5569630845039641 0.6652070598868384 27.856517473024216 -9.936492523436083 6.805384800847637 1.0000000225048942 0.6110850721954091 0.9450922420495982 0.04419041790308139 1.507886530596584e-08 2.3421851972275047e-09 0.04278719070045022 0.014262396050046805 1.1574639581542424e-10 9.936492523436083 -0.3889149503094851 VQVEYK(ub)GETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQVEYKGETK 10 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 228292000.0 74723000.0 66029000.0 87540000.0 True False 102350112.41314726 63111620.451296106 66864854.94289259 1.0 0.6166248278901664 0.6532953737557746 26.608937446001512 -9.752369057058134 6.189304558970692 1.0000000069244288 0.6349601012728193 0.9924882559353418 0.014970687662136073 1.4396295179254635e-09 2.7918729232964865e-10 0.014495306214241891 0.004831768666081715 1.7686053847275542e-10 9.752369057058134 -0.3650399056516095 VQVEYK(ub)GETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQVEYKGETK 10 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 1 323017000.0 86858000.0 151644000.0 84515000.0 True False 72226275.46182592 150827063.6730228 102186695.7467913 1.0 2.0882575310523954 1.4148133085001802 26.106020440138202 -10.083345292899946 4.810002507280746 0.99997070403824 1.7515354197847777 0.6241283720987578 0.2749324526089484 35417158.70558143 74246003.40918405 6901.2740018068735 0.09411669840511969 8.253814556667262e-11 10.083345292899946 0.7515647157465377 VQVEYKGETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQVEYKGETK 10 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 12936100.0 4383500.0 2315500.0 6237100.0 False True 5746810.9498743825 1970036.4257483052 5591744.72248784 1.0 0.34280515627391006 0.9730169952101988 22.454330159620728 -10.943719413722038 10.218177951857427 1.0910026348953423 0.6579110757421237 0.2820554759053783 0.25728290587582725 0.12121388011777078 0.000667631859443688 0.05661203331091334 0.0830377008100774 1.1383625144656771e-11 10.943719413722038 -0.4330915591532186 VQVEYKGETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQVEYKGETK 10 1 P11142;E9PKE3;P11142-2;E9PLF4;E9PQQ4;E9PQK7;E9PK54;E9PPY6;P54652;E9PN25;E9PN89 P11142;E9PN89 HSPA8;HSPA2 Heat shock cognate 71 kDa protein;Heat shock-related 70 kDa protein 2 0 15674000.0 4383500.0 9250300.0 2040200.0 False True 6004198.409633321 8841591.159348546 1558346.7792379432 1.0 1.4725681191951991 0.2595428520046379 22.51754022114362 -6.801014102315247 1.451550245294515 1.2603875979126247 0.24231969680354976 0.835227363214356 0.20264626832420468 0.21927465820370143 0.9119821524131265 0.1098197964291594 0.2552691946652939 1.5811966941641967e-07 6.801014102315247 -1.018067901109075 down VQVQVVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQVQVVER 8 0 O75955;A0A140T9R1;O75955-2;A0A140T9W4;A2AB09;A0A140T9X0;A0A140T907 O75955 FLOT1 Flotillin-1 0 2422940.0 923810.0 652220.0 846910.0 False True 1211123.8561887671 554911.318333648 759279.877334366 1.0 0.45817883571369344 0.6269217416984179 20.2079149798331 -10.37528474961126 5.085575296866849 1.0003043034757455 0.5425502887060117 0.9073974099176016 0.06888900289632366 0.00023783829059383993 2.9216226387630372e-05 0.06674500268734694 0.02223383007950234 4.214201044323491e-11 10.37528474961126 -0.45775401476973376 VQVQVVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQVQVVER 8 0 O75955;A0A140T9R1;O75955-2;A0A140T9W4;A2AB09;A0A140T9X0;A0A140T907 O75955 FLOT1 Flotillin-1 0 2147480.0 923810.0 505600.0 718070.0 False True 1265367.5220265463 483260.92020438466 548476.6551158666 1.0 0.381913485048533 0.4334524520097174 20.27112504135599 -10.324315457439653 8.867314902377993 1.000000604013472 0.40768297042745477 0.9943536842478654 0.021040695154177093 2.5125662254528616e-07 1.9137552261862464e-08 0.02037258612117358 0.00679085516039628 4.738976363256261e-11 10.324315457439653 -0.5923176335860172 VQVSVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQVSVLK 7 0 P00966 P00966 ASS1 Argininosuccinate synthase 0 65943000.0 21163000.0 22000000.0 22780000.0 False True 27744897.9427835 18717685.755328327 20422944.1211898 1.0 0.6746352354198092 0.7360972876276823 24.72571916038094 -10.71245910244886 6.808919384892274 1.0032466814880048 0.7053662615237484 0.968394493167543 0.025091777742264912 0.001247061053987252 5.266335819790737e-05 0.024499296443049916 0.008098336443544157 1.938835207644771e-11 10.71245910244886 -0.2978804199642564 VQVSVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQVSVLK 7 0 P00966 P00966 ASS1 Argininosuccinate synthase 0 37061400.0 10413000.0 6083400.0 20565000.0 False True 10082445.014788019 8512533.344511915 15178409.563224336 1.0 0.8442925631656311 1.5054294410693059 23.265342202153793 -6.844618408356642 1.260753396683583 0.9171484571630291 1.5292431246012899 0.9321096990298956 0.07353317787397308 0.16347314755756712 0.5027321483855022 0.04569543120072959 0.10544237035309735 1.4301500039587685e-07 6.844618408356642 0.6120946674382608 VQVSVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQVSVLK 7 0 P00966 P00966 ASS1 Argininosuccinate synthase 0 55909800.0 9246100.0 37794000.0 8869700.0 False True 14027009.680453988 31049365.414130174 7116599.907272386 1.0 2.2135413121868788 0.5073497537532216 23.74170414793803 -6.715695512104814 1.7748926158876206 1.741669727674248 0.5106414630723066 0.4921369567127045 0.5109486158081625 0.3637247374221157 2.2368981185933277 0.22879559052475523 0.5772716184219325 1.9244404991462649e-07 6.715695512104814 -1.2310282646019415 VQVSVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQVSVLK 7 0 P00966 P00966 ASS1 Argininosuccinate synthase 0 63661000.0 21163000.0 16890000.0 25608000.0 False True 28987533.00857075 16143743.95223905 19559917.813314963 1.0 0.5569202438671075 0.6747700056962999 24.78892922190383 -10.204668585418545 7.9645372901977245 1.0000001778523628 0.6158451247817106 0.9340696684827503 0.048111963798341206 1.519309635814684e-07 1.5208771161805495e-08 0.0465842305015861 0.015528069545359147 6.242109956023956e-11 10.204668585418545 -0.38415505307065223 VQVSVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQVSVLK 7 0 P00966 P00966 ASS1 Argininosuccinate synthase 0 25555600.0 10413000.0 8872200.0 6270400.0 False True 8658870.874116287 8824403.697606182 7581511.648946122 1.0 1.0191171373146026 0.8755774002369427 23.04574747758807 -6.873333844227917 1.1162658095267046 1.011064634646558 0.8666191003501782 0.9679008145856669 0.011401843753707121 0.13370060989681545 0.30934336511196464 0.007909722009635571 0.018843473912053616 1.3386472673135353e-07 6.873333844227917 -0.14444553429637974 VQVSVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQVSVLK 7 0 P00966 P00966 ASS1 Argininosuccinate synthase 0 24241800.0 9246100.0 8732800.0 6262900.0 False True 11969258.717878923 8246812.0032518525 5123116.462780686 1.0 0.688999394000339 0.4280228695473094 23.51283047003048 -7.284548532344943 0.19346672417586383 1.1909228677961308 1.9143460841494254e-10 0.9999830004066071 0.0009639787512879047 0.10471979449389852 0.011371017420166017 0.018846237550332608 0.04537990292266853 5.1933963413583416e-08 7.284548532344943 -1.1909228676046961 down VQVSYK(ub)GETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQVSYKGETK 10 1 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 11336300.0 3414000.0 4371500.0 3550800.0 True False 4475787.061223028 3719289.239973541 3183397.277678698 1.0 0.8309799347239788 0.7112485992148208 22.093709970020697 -6.974838693498678 0.08246533412846462 1.4015486587145431 0.13767169436761778 0.999999883704472 3.998039261749332e-05 0.07476146658629645 0.0023953051858248884 0.013865465276897493 0.02268584648664647 1.0596472283298395e-07 6.974838693498678 -1.2638769643469254 VQVSYK(ub)GETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQVSYKGETK 10 1 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 16973800.0 3480800.0 6487200.0 7005800.0 True False 3370303.90929359 9077572.790301086 5170770.810505085 1.0 2.6933988846732015 1.5342149994980332 21.68444725825716 -10.509181762705929 5.246882702330628 0.9970382786168572 2.1138069420856263 0.5517681457058432 0.47323483945605255 0.01641787428847969 0.001535804464765111 0.45883366203615294 0.15273588767153162 3.0961232258388213e-11 10.509181762705929 1.116768663468769 VQVSYK(ub)GETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQVSYKGETK 10 1 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 52367800.0 5611800.0 12648000.0 34108000.0 True False 8513510.877534486 10390865.58072496 27366538.849932536 1.0 1.220514747698796 3.2144833363809466 23.021322775390963 -6.927891540420346 0.7639002905377777 0.967188355487564 3.6026901535606135 0.9961074118772442 0.06214219472742679 0.09374741756675281 0.08315245732271394 0.05592016401709481 0.18255609034663947 1.1806154426824268e-07 6.927891540420346 2.6355017980730495 up VQVSYK(ub)GETK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQVSYKGETK 10 1 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 35210800.0 5611800.0 11734000.0 17865000.0 True False 7264585.725115766 11080992.584985029 14613753.31037969 1.0 1.5253440463473154 2.0116430397201777 22.792449097483413 -6.972052309077903 0.20327466613042852 0.7224962626847606 2.8279655019128485 0.9999942753547203 0.000988385465068529 0.07564223208072367 0.006590134576321838 0.015371149961190657 0.05120687194625675 1.0664676616203566e-07 6.972052309077903 2.105469239228088 VQVSYKGETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQVSYKGETK 10 1 P0DMV9;P0DMV8;A0A0G2JIW1 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 0 8128800.0 429900.0 6247300.0 1451600.0 False True 652189.7298998672 5132420.504622317 1164690.6237411178 1.0 7.869520584769579 1.7858156458856482 19.314932197431823 -6.616934532372137 2.1279771170194963 5.567932150295456 1.808641467436352 0.0725476245083796 2.9564589824167467 0.5937314287288182 5.104500398063872 1.1432755389520604 3.2793335299019395 2.4158249800125e-07 6.616934532372137 -3.759290682859104 VQVSYVIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQVSYVIR 8 0 Q8TAF3-3;Q8TAF3;F8W7Y5;F8W6P2;F8W9K4;F8W7Q3 Q8TAF3-3 WDR48 WD repeat-containing protein 48 0 6635500.0 2111100.0 2478600.0 2045800.0 False True 2767672.543921483 2108802.54150713 1834120.2406993026 1.0 0.7619407672120027 0.662694091007081 21.400241830504545 -13.999999999999993 0.11997576987016334 2.1346462557279846 0.5042387059643706 0.9996930595406214 0.0024797011447109823 11.963852803150182 0.10659718942235695 3.2367617844710743 0.1406110206547702 1.0000000000000164e-14 13.999999999999993 -1.6304075497636141 VQVSYVIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQVSYVIR 8 0 Q8TAF3-3;Q8TAF3;F8W7Y5;F8W6P2;F8W9K4;F8W7Q3 Q8TAF3-3 WDR48 WD repeat-containing protein 48 0 6629400.0 2111100.0 1270400.0 3247900.0 False True 2891630.720332364 1214269.5273489933 2480812.912600192 1.0 0.41992551774018544 0.857928675040168 21.463451892027436 -9.841508727965179 6.36302282102023 1.0000000153492976 0.6389270963901156 0.47536735938745733 0.17881404018577482 3.905997772621196e-08 6.8927550823564e-09 0.173135957666539 0.05771198330892256 1.4404270618620606e-10 9.841508727965179 -0.36107291895918203 VQVSYVIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQVSYVIR 8 0 Q8TAF3-3;Q8TAF3;F8W7Y5;F8W6P2;F8W9K4;F8W7Q3 Q8TAF3-3 WDR48 WD repeat-containing protein 48 0 4442040.0 2120200.0 996240.0 1325600.0 False True 1763040.2407856854 990873.0573818419 1602776.8311181061 1.0 0.5620252076267227 0.9090982690241041 20.74963397337501 -9.87209920191785 6.453288242661344 1.0000000139205159 0.7355617383253886 0.4363047183330583 0.14169198398162985 2.8370182482089163e-08 5.068622978478963e-09 0.13719267969593013 0.04573089118764851 1.3424582806418164e-10 9.87209920191785 -0.2644382755951272 VQVVGTYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQVVGTYR 8 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 63062000.0 22708000.0 16472000.0 23882000.0 False True 29770407.904584806 14014441.807353124 21410919.732320227 1.0 0.4707507486047856 0.7192014231361212 24.827375653267836 -10.402204564930297 6.0283032552989555 1.00010087615008 0.5949760858704555 0.7799003279650346 0.10142956314201194 0.00013754890969870545 1.3639984902892984e-05 0.09823301770081246 0.03273625073850873 3.960914200962035e-11 10.402204564930297 -0.40512479027962456 VQVVGTYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VQVVGTYR 8 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 32573400.0 7673800.0 3389600.0 21510000.0 False True 7430199.419425751 4743084.956530487 15875885.713832004 1.0 0.6383523091089607 2.136670204614641 22.824969501158805 -6.842951291992665 1.2685386174984903 0.8076146116107871 2.188924159910926 0.9294161293571975 0.16960248636599376 0.16538565634537342 0.5156805690977386 0.10477960595450982 0.24162828812447854 1.4356504387401283e-07 6.842951291992665 1.381309548300139 up VQVVGTYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VQVVGTYR 8 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 44619600.0 12586000.0 23248000.0 8785600.0 False True 19093882.159850527 19099212.76254692 7049122.309134733 1.0 1.0002791785689136 0.3691822464452622 24.186607124907937 -6.906792312527023 0.9172793874521608 1.021577428550166 0.29297520186529924 0.9896541847563195 0.03025353484811868 0.10657852474408216 0.15054765151224367 0.024382608045519297 0.06590292679068088 1.2393891431289422e-07 6.906792312527023 -0.7286022266848667 down VQVVGTYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VQVVGTYR 8 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 47704400.0 22708000.0 9642400.0 15354000.0 False True 31103761.26062586 9216366.88484722 11727701.425555998 1.0 0.29631036605576655 0.3770509080007006 24.890585714790728 -10.571664162036278 6.42281581771339 1.0011765231569494 0.33668063703620993 0.989009944002782 0.03296218822014516 0.0005561365682182734 3.708855611000319e-05 0.03196239545301537 0.010638500502598045 2.681240914857675e-11 10.571664162036278 -0.6644958861207395 VQVVGTYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VQVVGTYR 8 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 24464900.0 7673800.0 11220000.0 5571100.0 False True 6381104.706981043 11159555.633004384 6735991.252143989 1.0 1.7488438358950025 1.0556152204765883 22.60537477659308 -10.176186316812355 4.739469535757434 0.9999498775136679 1.402229528188115 0.3098133989753836 0.28300939715316875 0.00014990682826780634 2.6056093141568835e-05 0.2740567306137386 0.0913408901650717 6.66520763585784e-11 10.176186316812355 0.40227965067444704 VQVVGTYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VQVVGTYR 8 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 38901000.0 12586000.0 15549000.0 10766000.0 False True 16292825.107150495 14683684.481330508 8806698.468488546 1.0 0.9012362426259779 0.5405261770485412 23.957733447000386 -6.946966147391937 0.5912139071156769 1.0041544725100973 0.41941963272905347 0.9989411816996969 0.006425868755750017 0.0847273530142282 0.04118401561638889 0.006653626157488702 0.030229565288263455 1.1298839840141178e-07 6.946966147391937 -0.5847348397810438 VQYPDAK(ub)PVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VQYPDAKPVR 10 1 Q9Y4X5;H3BNB9 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 3113800.0 0.0 1454500.0 1659300.0 True False 0.0 1237494.2695965946 1487611.5531295126 0.0 VRDDVAEYK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 VRDDVAEYKR 10 2 Q13895;H7BY94 Q13895 BYSL Bystin 1 5586900.0 1745000.0 2304600.0 1537300.0 True False 2287711.898604041 1960762.663260442 1378234.9428228762 1.0 0.8570846112471142 0.6024512717986358 21.125473948089976 -6.962240545259208 0.40261426206672446 1.013600227652657 0.4365986197022575 0.9998444817080812 0.002050434502722935 0.07891025403084598 0.01824383902136659 0.0032757452121501738 0.021313680023713526 1.0908359813038363e-07 6.962240545259208 -0.5770016079503995 VRDDVAEYK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VRDDVAEYKR 10 2 Q13895;H7BY94 Q13895 BYSL Bystin 1 5647900.0 1498000.0 2221900.0 1928000.0 True False 1245653.3726520885 2209930.1836873833 2331135.8859352036 1.0 1.7741132743712464 1.8714161877730418 20.248471235497018 -11.146041072183632 0.37046345262305413 6.142012046080571e-10 1.8836324750552864 0.9994789039754136 0.0089000846351219 3.1076071031929717 0.185083698161339 2.619355229825069 0.02709436530685624 7.14428757782751e-12 11.146041072183632 1.8836324744410853 VRDDVAEYK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VRDDVAEYKR 10 2 Q13895;H7BY94 Q13895 BYSL Bystin 1 33221500.0 2012300.0 4068200.0 27141000.0 True False 2604962.0183631736 3841801.0937647857 22201616.49017718 1.0 1.4748011935232666 8.522817735410804 21.312830906772845 -6.9205530421206065 0.8206140951349469 0.8475679189850512 9.673960376541947 0.9943331582028858 0.2589460740343319 0.09784756353169799 0.1039360175686852 0.22376402425643258 0.6738650747997795 1.2007344135664865e-07 6.9205530421206065 8.826392457556896 up VREEFK(ub)ELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VREEFKELK 9 2 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 20838500.0 7548800.0 7964600.0 5325100.0 True False 7309167.476004203 11144906.314840306 3930296.5604243004 1.0 1.5247846422220763 0.537721508410822 22.80127565995609 -6.762266827971186 1.6039647177917966 1.3039613348151629 0.5337079860090964 0.7001594252568104 0.22080279895094543 0.27911702174355796 1.415768579649108 0.10859029101603122 0.260375978967132 1.7287538966534033e-07 6.762266827971186 -0.7702533488060664 VREEFK(ub)ELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VREEFKELK 9 2 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 30228800.0 13740000.0 10880000.0 5608800.0 True False 20844584.528551254 8938378.994172009 4500218.22157563 1.0 0.4288106093901237 0.21589387955473946 24.313169281041347 -12.1187719906777 0.16507320759212182 2.529180270712839 2.896091960728247e-15 0.9995267757120969 0.007201808519677814 5.665862860240967 0.11083542735299527 3.126918452231313 0.17719864697983034 7.60725561302873e-13 12.1187719906777 -2.529180270712836 VREEFK(ub)ELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VREEFKELK 9 2 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 11482000.0 4907200.0 3558700.0 3016100.0 True False 6721524.452093681 3401464.866952819 2303759.298529342 1.0 0.5060555668875533 0.34274357178180703 22.68035704489551 -13.999999999999996 0.1546803751696268 3.4072814396292754 0.17238923578284565 0.9995513768371292 0.005918139230700058 11.978409886980359 0.12408521467096637 8.657136235964302 0.15429225740821484 1.0000000000000082e-14 13.999999999999996 -3.23489220384643 VREEFK(ub)ELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VREEFKELK 9 2 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 19929700.0 7548800.0 10151000.0 2229900.0 True False 6277161.668542111 10096314.548184268 2696161.7801073217 1.0 1.6084203468554548 0.42951925129140617 22.581680935390366 -6.7664066036436195 1.5879990563569217 1.3505646078027418 0.4237352435180258 0.716729851532344 0.25619880757293223 0.2722664025252942 1.3543888678824791 0.12720565644469192 0.30383719244330587 1.7123533839408877e-07 6.7664066036436195 -0.9268293642847161 VREEFK(ub)ELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VREEFKELK 9 2 P02545;P02545-3;P02545-6;P02545-2;Q3BDU5 P02545;P02545-2 LMNA Prelamin-A/C;Lamin-A/C 1 28138300.0 13740000.0 11791000.0 2607300.0 True False 17786700.85589128 11134820.484877994 2132798.1531571746 1.0 0.6260194386296174 0.11990971065613626 24.084295603133796 -7.533550713046765 0.49403232080193543 1.0158680930549873 6.124868060431735e-21 0.9970019015149391 0.019746943934371028 0.11706731720960549 0.072343968083373 0.02292563140372376 0.07003202595924456 2.927179041479231e-08 7.533550713046765 -1.0158680930549873 down VREEVPLELVEAHVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VREEVPLELVEAHVK 15 1 Q92922 Q92922 SMARCC1 SWI/SNF complex subunit SMARCC1 0 5430200.0 2183300.0 1144000.0 2102900.0 False True 2113992.3365780003 1600805.165881188 1552087.4043522687 1.0 0.7572426532408684 0.7341972709630024 21.011538716148387 -13.999999999999998 0.33303668501197126 3.6914616637199753 0.7302596283692567 0.9997211080990883 0.002007963268572459 19.08265600657337 0.18470321645850066 36.031116574269014 0.0073021199309871755 1.0000000000000041e-14 13.999999999999998 -2.9612020353507185 VRPCVVYGGADIGQQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VRPCVVYGGADIGQQIR 17 1 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 49064000.0 12340000.0 14173000.0 22551000.0 False True 16177859.500729978 12058443.645921296 20217638.844466705 1.0 0.7453670644980688 1.2497103738324866 23.94751740102974 -6.769411445712875 1.5764773660299138 0.8538451637149299 1.2525016805510556 0.7284306979374848 0.10729954283054614 0.2673585004056103 1.3112113175773805 0.05364956593817736 0.12778922129458167 1.7005466661889318e-07 6.769411445712875 0.3986565168361257 VRPCVVYGGADIGQQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VRPCVVYGGADIGQQIR 17 1 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 0 42567300.0 12340000.0 9867300.0 20360000.0 False True 16902431.475961026 9431330.059202379 15551387.32736229 1.0 0.5579865874691344 0.9200680594078895 24.01072746255263 -9.972373431147014 6.87765389877413 1.0000000223323882 0.7390273234385113 0.40921173049748727 0.14781914192763884 5.05788691676886e-08 7.752400408860774e-09 0.1431252815304816 0.04770842291136756 1.0656793952804694e-10 9.972373431147014 -0.26097269889387686 VRPDATTK(ub)EVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VRPDATTKEVK 11 2 P17480 P17480 UBTF Nucleolar transcription factor 1 1 2138700.0 0.0 0.0 2138700.0 True False 0.0 0.0 1917407.8398590304 0.0 VRPDATTK(ub)EVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VRPDATTKEVK 11 2 P17480 P17480 UBTF Nucleolar transcription factor 1 1 7334930.0 1600200.0 777030.0 4957700.0 True False 2427620.3902902277 638362.9255368994 3977808.421962899 1.0 0.262958297800663 1.6385627826627962 21.211111412720605 -6.761186970043042 1.6082689902666958 0.5725140079385774 1.6438412576282375 0.6957046367092686 0.31005323951064895 0.2809213644402587 1.4323871085766051 0.15209965626785527 0.3650533404411565 1.733057730758357e-07 6.761186970043042 1.0713272496896602 VRPDATTK(ub)EVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VRPDATTKEVK 11 2 P17480 P17480 UBTF Nucleolar transcription factor 1 1 2343000.0 0.0 1239100.0 1103900.0 True False 0.0 1184352.4648442497 843181.5555341454 0.0 VRPDATTK(ub)EVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VRPDATTKEVK 11 2 P17480 P17480 UBTF Nucleolar transcription factor 1 1 4816360.0 1600200.0 461160.0 2755000.0 True False 2071490.444657732 435496.0406077803 2253618.268687158 1.0 0.21023318824902248 1.0879211509274032 20.982237734813054 -6.6695944620525855 1.9386507264743562 0.4957204848605763 1.0843789921830957 0.2772962182948976 0.33550702053378934 0.4620623658302632 3.347567641324884 0.13933847269562344 0.3724961105939457 2.1399594201781517e-07 6.6695944620525855 0.5886585073225195 VRPGETLLIHSGSGGVGQAAIAIALSLGCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VRPGETLLIHSGSGGVGQAAIAIALSLGCR 30 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 48368000.0 13523000.0 20170000.0 14675000.0 False True 20515379.663726244 16570505.91107069 11774479.817718996 1.0 0.8077113942165748 0.573934287871735 24.290202517633148 -6.968513245927531 0.2915202203155614 1.0448558256021212 0.3295517691295836 0.99996834985346 0.000980091311929161 0.07678816304055759 0.01074809567267608 0.004051159700845577 0.021162943132647483 1.0751938066156254e-07 6.968513245927531 -0.7153040564725376 VRPGETLLIHSGSGGVGQAAIAIALSLGCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VRPGETLLIHSGSGGVGQAAIAIALSLGCR 30 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 27872300.0 13523000.0 7660200.0 6689100.0 False True 17505790.07818179 7233903.136143025 5471752.435961975 1.0 0.413229171824638 0.31256815096747065 24.061328839725597 -13.999999999999998 0.2480111414745538 5.040168506158602 0.2713212688162631 0.9995389908735163 0.006508558738402431 13.920012184557638 0.1575903040727404 27.984736765156068 0.04697378006800345 1.0000000000000041e-14 13.999999999999998 -4.768847237342339 VRPGFCFHLCSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VRPGFCFHLCSR 12 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 709574500.0 155330800.0 282102700.0 272141000.0 False True 203640183.02560678 240014076.7877117 243982459.88080433 1.0 1.1786184495696073 1.1981056796149347 27.601447026464303 -13.144236958750719 0.32411611915786437 4.751518676555839e-09 1.201898621855999 0.9996608618258137 0.0016417574921165478 10.612720534278438 0.17959244396905646 7.066790670619705 0.006387404971107953 7.174027568341435e-14 13.144236958750719 1.2018986171044803 VRPGFCFHLCSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VRPGFCFHLCSR 12 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 5182720000.0 1227700000.0 1164660000.0 2790360000.0 False True 1862510656.8924587 956817323.4698867 2238844122.9417634 1.0 0.5137244825574887 1.2020570806704567 30.79460153438088 -6.7168465527274135 1.7702483855050042 0.7031817718269876 1.2008340056498175 0.49786860028723035 0.20470771379985053 0.36143603711276945 2.211746855217507 0.09187248570355507 0.23153023493847932 1.9193467748514905e-07 6.7168465527274135 0.49765223382282986 VRPGFCFHLCSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VRPGFCFHLCSR 12 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 742163800.0 155330800.0 278132000.0 308701000.0 False True 212760794.41703457 265843208.5804707 235792181.6966629 1.0 1.2494934008348775 1.1082501470382944 27.664657087987194 -10.443571881074721 4.555255898292252 0.9994777609505645 1.1788717739367447 0.6813652950304214 0.057662316902550116 0.00030671078608692724 3.746492010286376e-05 0.05599262566807204 0.018610432755533028 3.60104143800169e-11 10.443571881074721 0.17939401298618018 VRPGFCFHLCSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VRPGFCFHLCSR 12 1 Q08211 Q08211 DHX9 ATP-dependent RNA helicase A 0 4827310000.0 1227700000.0 1764200000.0 1835410000.0 False True 1589281851.5849876 1666020719.1435637 1501384212.896948 1.0 1.0482852475047422 0.9446934861803277 30.56572785647333 -6.78000646575078 1.5363062749563423 1.0273406259103333 0.9438794885066608 0.7672497490483359 0.02041864507404928 0.25057058310627606 1.1682159467363074 0.010469054235602935 0.02469767864226131 1.6595621997889214e-07 6.78000646575078 -0.08346113740367245 VRPQAEGTPGSTGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VRPQAEGTPGSTGKR 15 2 Q6IQ32 Q6IQ32 ADNP2 ADNP homeobox protein 2 1 2426400.0 420220.0 484330.0 1521850.0 True False 406880.3461167987 677725.4947475834 1123231.8304786256 1.0 1.6656628938106441 2.7605949542625283 18.634245068820825 -6.963680199531472 0.38003007686689294 0.9248141382389887 3.5401647125842812 0.9998832907541363 0.007841466357057696 0.07841180842386912 0.016457466895728325 0.014249024998830894 0.09251933774255414 1.08722592707691e-07 6.963680199531472 2.6153505743452925 VRPQAEGTPGSTGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VRPQAEGTPGSTGKR 15 2 Q6IQ32 Q6IQ32 ADNP2 ADNP homeobox protein 2 1 1884290.0 664240.0 653590.0 566460.0 True False 909827.4784110512 624712.2326668984 432673.8146099033 1.0 0.6866271326053086 0.4755558882059017 19.79523348168531 -8.194227089696984 0.13448119800024957 1.4192105159294766 7.268021945631771e-13 0.9999559604891104 0.0014298095639631635 0.08547096843749098 0.026564876670927773 0.12457345591334931 0.1318131039945506 6.39400409832835e-09 8.194227089696984 -1.4192105159287498 down VRPQAEGTPGSTGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VRPQAEGTPGSTGKR 15 2 Q6IQ32 Q6IQ32 ADNP2 ADNP homeobox protein 2 1 2337200.0 420220.0 957100.0 959880.0 True False 349431.54890244396 951943.9123305246 1160586.4700163312 1.0 2.724264352547895 3.3213557094707253 18.4146503442551 -9.638301182701749 0.2963403730784869 6.0127501254106215e-15 3.556325996504437 0.9987829557467733 0.03433584804676968 1.0165812835305776 0.12327429592151813 1.1690897081684763 0.21345771334752348 2.2998463235719169e-10 9.638301182701749 3.5563259965044307 VRVDSTAK(ub)VAEIEHAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VRVDSTAKVAEIEHAEK 17 2 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 23209300.0 6080100.0 4268200.0 12861000.0 True False 9223956.214850403 3506506.3624011907 10319017.712823447 1.0 0.38015210401321925 1.1187192862223276 23.136954234008556 -6.684109680202754 1.8871941255875502 0.6092692955186335 1.1160102331295634 0.34303703646556116 0.26247395918073424 0.42947640973507306 2.9606896495674673 0.11145499759727862 0.29242631325205176 2.0696186047457418e-07 6.684109680202754 0.5067409376109299 VRVDSTAK(ub)VAEIEHAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VRVDSTAKVAEIEHAEK 17 2 P78371;F5GWF6;P78371-2;F8VQ14 P78371 CCT2 T-complex protein 1 subunit beta 1 25688700.0 6080100.0 7735600.0 11873000.0 True False 7870809.306688838 7305107.059861099 9712235.827267729 1.0 0.928126546485253 1.233956439398677 22.908080556101005 -6.844767453187974 1.2600964367650176 0.9617552561985091 1.2450010922599084 0.9323380099894617 0.03396338602846373 0.16330606216475085 0.5016329957841311 0.021116341431944092 0.048727817067913785 1.4296592772680788e-07 6.844767453187974 0.2832458360613993 VRVELSNGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VRVELSNGEK 10 1 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 0 96684000.0 26118000.0 36736000.0 33830000.0 False True 34240950.92707182 31255131.995806478 30329596.120274466 1.0 0.9127997660571783 0.8857696792613043 25.029219432502018 -13.999999997724693 0.16401114205354675 1.4332892736667748 0.8603396646261916 0.9995263838424023 0.001060768526920422 12.038874907570397 0.1281051399130345 1.659119450519504 0.023299593498988063 1.0000000052390881e-14 13.999999997724693 -0.5729496090405832 VRVELSNGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VRVELSNGEK 10 1 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 0 61389500.0 18345200.0 13109300.0 29935000.0 False True 17762841.667654768 18343911.8540964 22094125.46924968 1.0 1.0327126817495498 1.2438395771709185 24.08235906413648 -6.934310670162711 0.7105093323432605 0.997245173968932 1.2923602762112807 0.9973198609987115 0.005594529162412654 0.09046020654764962 0.06716024920441356 0.005234582348112959 0.018671265479697326 1.1632935760558862e-07 6.934310670162711 0.2951151022423487 VRVELSNGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VRVELSNGEK 10 1 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 0 209189000.0 52756000.0 115136000.0 41297000.0 False True 80034708.98022187 94589081.2383261 33134629.84888186 1.0 1.1818507550480493 0.41400325272713956 26.254122459387403 -6.844238950668089 1.2624495325048766 1.0967600676801879 0.3865361415982499 0.9315082886474141 0.08574285326452932 0.16391311203422212 0.5056042197484034 0.0532131397250441 0.12277666212405378 1.431400120149443e-07 6.844238950668089 -0.710223926081938 down VRVELSNGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VRVELSNGEK 10 1 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 0 82100100.0 26118000.0 20848100.0 35134000.0 False True 35774530.41241092 19926962.00655268 26836072.807443317 1.0 0.5570153340053238 0.7501446559346963 25.09242949402491 -10.254690154619928 5.583535388816855 1.0000238857601145 0.6535799949699997 0.8109608843731246 0.07884471551614781 2.3445102513636655e-05 3.1296217852646773e-06 0.07634632400089335 0.02544702251086986 5.5630100609209874e-11 10.254690154619928 -0.34644389079011473 VRVELSNGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VRVELSNGEK 10 1 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 0 42675400.0 18345200.0 12053000.0 12277200.0 False True 15254846.630158268 11988068.09666683 14844305.756640915 1.0 0.7858530726206622 0.9730878399848525 23.862764339570756 -10.220718478816776 6.589115834305764 1.000000883725323 0.8794704563472081 0.3558884295681769 0.07643827369182993 9.923483160166958e-07 1.1733129475289536e-07 0.07401158284797293 0.024670346751775134 6.015635605520746e-11 10.220718478816776 -0.12053042737811481 VRVELSNGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VRVELSNGEK 10 1 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 0 148872000.0 52756000.0 61623000.0 34493000.0 False True 68293681.97622992 58193625.87902951 28215627.92806757 1.0 0.8521084849296044 0.41315136498114435 26.025248781479853 -6.951690652189856 0.5399632160683678 1.0064641420658487 0.23852589398450663 0.999327373176043 0.006463247884110105 0.08281386293648103 0.03320698267268247 0.007109197626159356 0.03635165630583205 1.1176590724871483e-07 6.951690652189856 -0.767938248081342 down VRVELSNGEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 VRVELSNGEKR 11 2 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 1 9511710.0 477410.0 4555500.0 4478800.0 True False 724265.8733461163 3742535.4327160423 3593563.2168722264 1.0 5.167350237593672 4.9616630427027095 19.466159873051268 -10.151245953529589 4.30933658122651 0.9991071557875937 5.064506640407791 0.9980829794858742 0.08397144657865882 14803093.793329347 25136427.275380623 174242.99969446493 0.030730404198251092 7.059176594443411e-11 10.151245953529589 4.0653994846201975 VRVELSNGEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VRVELSNGEKR 11 2 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 1 7333740.0 3338300.0 3230100.0 765340.0 True False 4572559.724165381 3087383.5014877054 584582.4546720752 1.0 0.6751980701687256 0.12784577784356393 22.12457058308045 -7.383643393338577 0.5287614593143193 1.0084419815185475 4.425933265041544e-22 0.9974060911539212 0.018329796292014262 0.10812996932452183 0.06327758704431422 0.019175339609397542 0.06300244139491368 4.133868016746348e-08 7.383643393338577 -1.0084419815185475 down VRVELSNGEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VRVELSNGEKR 11 2 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 1 9254330.0 4072000.0 4856300.0 326030.0 True False 3386048.4201864493 4830138.147999918 394201.3656076014 1.0 1.4264823028531741 0.11641929372820224 21.69117117311396 -6.819016595292788 1.3760243749738785 1.2300924505078796 0.0883837327012974 0.8821611951115081 0.18728305911454354 0.19473660706982399 0.724769681336198 0.10696141903153472 0.24660781145340815 1.5169923989263123e-07 6.819016595292788 -1.1417087178065821 down VRVELSNGEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VRVELSNGEKR 11 2 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 1 14693410.0 477410.0 9877700.0 4338300.0 True False 618016.656158009 9327997.311803866 3548773.9147170596 1.0 15.093439988806656 5.742197850748121 19.237286195143717 -9.717712351046227 13.19896506603786 0.9999985702600527 10.417818919777389 0.5748997745385211 3.8176286165761257 0.0 0.0 3.6964030135010084 1.232134337833669 1.9155242259772866e-10 9.717712351046227 9.417820349517337 VRVELSNGEKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VRVELSNGEKR 11 2 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 0 23266800.0 13394000.0 1780700.0 8092100.0 False True 17559663.707680505 1515026.5011142362 7254807.116904316 1.0 0.08627878792755989 0.4131518255518243 24.065761879705114 -10.498806091555384 6.158398867832867 1.0006147153914313 0.24971530816404033 0.8753859876245906 0.13344535880883604 0.0011271186635444495 9.172941176578591e-05 0.12930388786551852 0.043069304357941256 3.170982961399584e-11 10.498806091555384 -0.750899407227391 VRVELSNGEKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VRVELSNGEKR 11 2 P84103;P84103-2 P84103 SRSF3 Serine/arginine-rich splicing factor 3 0 22377600.0 13394000.0 7698100.0 1285500.0 False True 18346123.75924004 7357972.487787531 981891.3757035453 1.0 0.4010641476285519 0.053520372400683004 24.128971941228006 -8.458403274814499 0.4247260119384959 1.0817864688621754 7.073631610415038e-18 0.9962286870611254 0.024006518925242536 0.17923271210258712 0.13175921230399706 0.08736501427186644 0.07661440551254008 3.4801400799189366e-09 8.458403274814499 -1.0817864688621754 VRVELSTGMPR ddPTM_RPMI8226_Bortezomib_1h_R1 2 VRVELSTGMPR 11 1 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 65696700.0 20590800.0 25818100.0 19287800.0 False True 26994738.201590832 21966140.11816558 17292083.477642003 1.0 0.8137193238966506 0.6405723718640457 24.6861748896263 -6.972004301355997 0.20472755807238846 1.0969787646837976 0.3525075901280877 0.9999940826593574 0.00035697594265305825 0.07565752095282008 0.006649309193309542 0.005408770876131054 0.018167687467421527 1.0665855574605245e-07 6.972004301355997 -0.74447117455571 VRVELSTGMPR ddPTM_RPMI8226_Bortezomib_2h_R1 2 VRVELSTGMPR 11 1 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 51471900.0 17864400.0 2785200.0 30822300.0 False True 17297304.40047817 3897344.884626124 22749014.98082025 1.0 0.22531515861618215 1.315176888497804 24.044043891029 -6.715823108893372 1.7744560928694797 0.5265938737919542 1.3130788005477319 0.4926669513064217 0.32616888727821663 0.3635067638689408 2.234535518324299 0.14608569473111727 0.3685282363391639 1.9238751768378517e-07 6.715823108893372 0.7864849267557776 VRVELSTGMPR ddPTM_RPMI8226_Bortezomib_8h_R1 2 VRVELSTGMPR 11 1 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 240957900.0 52316600.0 84987000.0 103654300.0 False True 79368107.0557791 69820405.84353815 83166982.17170636 1.0 0.8797035539031953 1.04786400050158 26.242056061556838 -6.714646125683562 1.7783993924775503 0.9263987763874408 1.0475297302489852 0.48722850173456145 0.05065712243641661 0.3658222088357652 2.2580344714996 0.022642761329143807 0.05720673017477849 1.929096150132575e-07 6.714646125683562 0.12113095386154438 VRVELSTGMPR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VRVELSTGMPR 11 1 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 75010840.0 20590800.0 30006140.0 24413900.0 False True 28203775.205447193 28680369.517764237 18647839.640053548 1.0 1.0168982453180593 0.6611823950593664 24.749384951149192 -6.895750471506385 0.9877672401605481 1.0165626266257197 0.6269085776976269 0.9843300995453523 0.020510455670297544 0.11460038432699536 0.19559618140620627 0.015689832297068048 0.040016882642270844 1.271304336776709e-07 6.895750471506385 -0.38965404892809286 VRVELSTGMPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VRVELSTGMPR 11 1 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 7870360.0 3057400.0 3089360.0 1723600.0 False True 2542363.565785378 3072717.0044900523 2083996.790974026 1.0 1.2086064502504932 0.8197084079633767 21.277738924234402 -6.760998079974192 1.6086968913547572 1.1210193586835024 0.818216126794549 0.6950416234419408 0.08775336413392128 0.28124073524371107 1.4346904221696006 0.043035122915174126 0.10331918243586563 1.7338116629580913e-07 6.760998079974192 -0.3028032318889534 VRVELSTGMPR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VRVELSTGMPR 11 1 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 0 269829100.0 52316600.0 118894600.0 98617900.0 False True 67724870.01436114 112278010.99324691 80670454.10510448 1.0 1.6578549500270465 1.1911496336279155 26.013182383649287 -10.268525022125875 4.232172561917136 0.9996598053372866 1.424502291840302 0.524510535965259 0.19053164761392546 19578901.120790947 47504635.14466707 37724.96948885773 0.06522405249167466 5.3885879781992434e-11 10.268525022125875 0.4248424865030155 VSAALEEADK(ub)MFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSAALEEADKMFLR 14 1 H0YN68;Q9Y6B2-2;Q9Y6B2 H0YN68 EID1 EP300-interacting inhibitor of differentiation 1 1 135927000.0 2119100.0 84634000.0 49173900.0 True False 3214829.6269616396 69530401.45153978 39454657.11131396 1.0 21.628020616835457 12.272705458610217 21.616310851869454 -9.625632391026953 9.050585281097497 1.0001625179727032 16.95036303772284 0.794906081148879 3.8192914212487055 0.0 0.0 3.698012686107102 1.2326710055604926 2.367923180246261e-10 9.625632391026953 15.950200519750139 VSAALEEADK(ub)MFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSAALEEADKMFLR 14 1 H0YN68;Q9Y6B2-2;Q9Y6B2 H0YN68 EID1 EP300-interacting inhibitor of differentiation 1 1 20979370.0 897070.0 1836900.0 18245400.0 True False 1228741.021405215 1755739.6841840097 13936212.295808244 1.0 1.428893195228485 11.341862974404883 20.228749443939677 -6.915975365252302 0.8540462759213812 0.7479773531478685 12.801248892130968 0.9929879227171325 0.40004389725257583 0.10059793020064456 0.11831398016749578 0.33752504607992845 0.9752151452063741 1.2134576802043137e-07 6.915975365252302 12.053271538983099 up VSAALEEADK(ub)MFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSAALEEADKMFLR 14 1 H0YN68;Q9Y6B2-2;Q9Y6B2 H0YN68 EID1 EP300-interacting inhibitor of differentiation 1 1 136329300.0 2119100.0 97316000.0 36894200.0 True False 2743216.7237059087 91900279.05236089 30179834.166460168 1.0 33.50091819512151 11.001622258152889 21.387437173961903 -9.631382669704434 10.945637294625747 1.0000452556245145 22.2512702229297 0.5432782748073441 9.18529910294514 0.0 0.0 8.893627216335195 2.9645425379644395 2.3367773276969184e-10 9.631382669704434 21.251224967305188 VSADEDLK(ub)LSDLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSADEDLKLSDLLK 14 1 A0A0A0MRI2;Q9UNH7;Q9UNH7-2 A0A0A0MRI2 SNX6 Sorting nexin-6;Sorting nexin-6, N-terminally processed 1 6114500.0 2323300.0 2441500.0 1349700.0 True False 1931926.8896412554 2428347.1549001914 1631916.0296922955 1.0 1.2569560307487193 0.8447089993117339 20.88160906828681 -6.738155316307946 1.6934090584640773 1.1532149180917912 0.8445620896079528 0.5966246360597265 0.10796790702648147 0.3211770877764553 1.8076944886572566 0.05045301668334208 0.12406072758569846 1.8274465513541506e-07 6.738155316307946 -0.30865282848383846 VSAGEAVVNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSAGEAVVNR 10 0 A2ACR1;P28065-2;P28065;A0A0G2JJA7;A2ACR0;A0A0G2JJQ0 A2ACR1 PSMB9 Proteasome subunit beta type;Proteasome subunit beta type-9 0 3833130.0 777220.0 716410.0 2339500.0 False True 752547.5765287188 1002476.2490287967 1726714.7665044167 1.0 1.3321101287083077 2.2944924950383143 19.521423267275686 -6.9522277711759655 0.533831438666355 0.9852272307759247 2.6853508029623776 0.9993646846036002 0.013836723891380066 0.0826034189827012 0.03235483668667213 0.015351138670384285 0.07962501437742238 1.1162776484492701e-07 6.9522277711759655 1.700123572186453 up VSAIASEGK(ub)AEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSAIASEGKAEER 13 1 A0A5H1ZRP4;Q8WX92;Q8WX92-2 A0A5H1ZRP4 NELFB Negative elongation factor B 1 6417300.0 2927900.0 1689400.0 1800000.0 True False 3838505.253823931 1437348.1052296218 1613753.2668192133 1.0 0.3744551616277537 0.4204118947633554 21.872113192063967 -9.888763025211682 6.964397406382165 1.0000000109877574 0.3974335281955498 0.9956563069701612 0.018761757737930596 3.189064047849171e-09 5.441564421948189e-10 0.018165994086831994 0.006055331272046056 1.2919240256272606e-10 9.888763025211682 -0.6025664827922076 VSAIASEGK(ub)AEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSAIASEGKAEER 13 1 A0A5H1ZRP4;Q8WX92;Q8WX92-2 A0A5H1ZRP4 NELFB Negative elongation factor B 1 25677600.0 7867100.0 6977500.0 10833000.0 True False 11934965.862049885 5732310.609543668 8691852.801727427 1.0 0.4802955178758356 0.7282679231924138 23.508691104052108 -10.120249617758427 5.412583107442421 1.000006849581758 0.604281720533971 0.7724948052896258 0.10123431055324508 8.36768906212442e-06 1.3602462940406907e-06 0.09802139549074775 0.03267323323638086 7.581416956088217e-11 10.120249617758427 -0.395725129047787 VSAIASEGK(ub)AEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSAIASEGKAEER 13 1 A0A5H1ZRP4;Q8WX92;Q8WX92-2 A0A5H1ZRP4 NELFB Negative elongation factor B 1 5904400.0 2927900.0 1426000.0 1550500.0 True False 4010423.75352239 1362994.6048485998 1184303.8335498623 1.0 0.3398629892044375 0.2953064080846015 21.93532325358686 -13.875907203342898 0.38388498114874636 9.99999971227188 0.2916175611341682 0.9998111795676694 0.00442751262009972 22.21064566179489 0.2021857015430273 164.82279379262295 0.011942821926912818 1.3307387294733291e-14 13.875907203342898 -9.70838215113771 VSAIASEGK(ub)AEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSAIASEGKAEER 13 1 A0A5H1ZRP4;Q8WX92;Q8WX92-2 A0A5H1ZRP4 NELFB Negative elongation factor B 1 8314200.0 1854700.0 3720900.0 2738600.0 True False 1542265.2271414099 3700854.7731591742 3311228.598144272 1.0 2.3996227808486044 2.146990374853771 20.556619459724853 -10.276082790725658 5.570023489257325 0.9998817783210743 2.2733065778512187 0.9713227837228174 0.1031367478632725 0.00015142882200647263 1.968059023764029e-05 0.09987076472764168 0.03328724223802144 5.295624823477542e-11 10.276082790725658 1.2734247995301444 VSAK(ub)NALESYAFNMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSAKNALESYAFNMK 15 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 28696600.0 6484600.0 11030000.0 11182000.0 True False 8501373.39695572 9384366.99460326 10024993.905318027 1.0 1.1038648176497852 1.1792205138181444 23.019264496800577 -6.9746157884205875 0.09786350416838978 0.8070518038478067 1.4779424362908697 0.9999997611552759 3.5441029474799285e-05 0.07483183260081225 0.002868719200235528 0.006997051572602709 0.012549255573071225 1.060191240248819e-07 6.9746157884205875 0.670890632443063 VSAK(ub)NALESYAFNMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VSAKNALESYAFNMK 15 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 65266300.0 16351500.0 23260800.0 25654000.0 True False 15832430.582858564 32548958.743469525 18934447.796496805 1.0 2.0558409255689134 1.195928047649028 23.91637941814893 -10.242397724344126 4.418204413605193 0.9997186474554299 1.6258844866183018 0.41395278629960996 0.3510579623902942 247811951.6219509 348.18106062143556 709310.4919075044 0.12017647811592341 5.722717078565251e-11 10.242397724344126 0.6261658391628718 VSAK(ub)NALESYAFNMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VSAKNALESYAFNMK 15 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 218743400.0 25797800.0 67550600.0 125395000.0 True False 39137148.67180927 55495667.65475326 100610623.28741911 1.0 1.4179793249661832 2.5707192961629715 25.22203531678114 -6.953325553760363 0.5210573573503923 0.9805707638340071 3.0596636932202443 0.9994370815726993 0.015759180659248962 0.0821772198844074 0.030643761584562702 0.017823237901030683 0.09522700602428118 1.113459554428076e-07 6.953325553760363 2.0790929293862375 up VSAK(ub)NALESYAFNMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSAKNALESYAFNMK 15 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 20177000.0 6484600.0 7161300.0 6531100.0 True False 8882131.859725837 6844890.086747743 4988588.692226711 1.0 0.7706359458346325 0.5616431697942269 23.08247455832347 -6.972235126551415 0.19765082726406358 1.1282314625780312 0.19829204839802161 0.999994968124454 0.00040153968497047326 0.07558398395257017 0.006363530960798424 0.006918332436957109 0.022320792274811777 1.0660188235600005e-07 6.972235126551415 -0.9299394141800096 VSAK(ub)NALESYAFNMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VSAKNALESYAFNMK 15 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 47791000.0 16351500.0 18517600.0 12921900.0 True False 13596996.744272776 18417842.01334419 15623809.545884904 1.0 1.3545522117670592 1.1490632703479793 23.696784693583208 -10.107434781621745 4.054578888860744 0.9999410170124842 1.2518077410325414 0.6669071045330235 0.08389050934174123 9360785.595378496 4666998.499241797 4710.573318788503 0.02871795319730764 7.808456916071866e-11 10.107434781621745 0.2518667240200573 VSAK(ub)NALESYAFNMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VSAKNALESYAFNMK 15 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37 P0DMV9 HSPA1B;HSPA1A Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A 1 135524700.0 25797800.0 51285000.0 58441900.0 True False 33395760.65066317 48430944.66686186 47806073.864532754 1.0 1.4502123540012892 1.431501272410258 24.99316163887359 -10.060712660531212 4.472963429969993 0.9999725552220745 1.4408568132383093 0.9986507952935917 0.007638767183086274 2648279.4402302527 0.018434249151619796 756.264565883113 0.002614953169560795 8.695355442280196e-11 10.060712660531212 0.44088425801623476 VSANK(ub)GEIGDATPFNDAVNVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSANKGEIGDATPFNDAVNVQK 22 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 35869200.0 8323200.0 10279000.0 17267000.0 True False 10911795.801983466 8745413.267228182 15480376.476759652 1.0 0.8014641609805881 1.41868275008828 23.37938521604859 -6.820132639735129 1.3712633637770986 0.8930045420457775 1.432199880491552 0.884697542979596 0.08735767680208292 0.19330796910028883 0.7141947267406218 0.050060993860962986 0.11538054192910649 1.5130990558057607e-07 6.820132639735129 0.5391953384457744 VSANK(ub)GEIGDATPFNDAVNVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSANKGEIGDATPFNDAVNVQK 22 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 39360400.0 5201400.0 10065000.0 24094000.0 True False 5036284.404102412 14084006.988281613 17783058.59549365 1.0 2.796507476188038 3.5309877617332495 22.26392832513779 -9.367975774880387 0.27936850892339665 8.808988847549577e-25 3.8904463151327153 0.9988526552992815 0.036011891929304436 0.7664090677510822 0.10808582692239674 1.001125050428649 0.2785655719655422 4.2857242567174215e-10 9.367975774880387 3.8904463151327153 VSANK(ub)GEIGDATPFNDAVNVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSANKGEIGDATPFNDAVNVQK 22 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 215238000.0 24121000.0 39997000.0 151120000.0 True False 36593320.48130889 32859222.852012623 121251065.76175107 1.0 0.8979568516827117 3.3134753601735483 25.12507699611069 -6.897037188933324 0.9798209646434423 0.8912455068621048 3.5522954078371636 0.9850333498720607 0.13645765785746605 0.11361870936517791 0.18997993101786154 0.1050074238580297 0.26936459401564894 1.2675433206096047e-07 6.897037188933324 2.661049900975059 up VSANK(ub)GEIGDATPFNDAVNVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSANKGEIGDATPFNDAVNVQK 22 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 38659200.0 8323200.0 7144000.0 23192000.0 True False 11400511.966022614 6828354.457951195 17714527.254233085 1.0 0.5989515627282356 1.5538361178014086 23.44259527757148 -6.7926304654849465 1.4859401996572135 0.7766155898565318 1.5647199470077495 0.8096821277384443 0.17078916161497001 0.23146072996990175 1.0095753052962895 0.09045772782236296 0.21137289998564532 1.612016692074058e-07 6.7926304654849465 0.7881043571512177 VSANK(ub)GEIGDATPFNDAVNVQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSANKGEIGDATPFNDAVNVQK 22 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 33515400.0 5201400.0 12296000.0 16018000.0 True False 4325194.561089837 12229759.007435095 19367289.741135962 1.0 2.827562745374745 4.477784633174029 22.044333600572067 -7.042701318244116 0.20077747323514555 8.214296134431598e-16 7.235386597515946 0.9999954106703872 0.003042909472425047 0.07269077411751741 0.00661052538117566 0.05598111916309172 0.1726859267158986 9.063557238296063e-08 7.042701318244116 7.235386597515945 VSANK(ub)GEIGDATPFNDAVNVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSANKGEIGDATPFNDAVNVQK 22 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 182079000.0 24121000.0 31258000.0 126700000.0 True False 31225109.995993674 29518464.822009694 103641900.05178319 1.0 0.9453438218727508 3.3191844661261696 24.89620331820314 -6.901633854548698 0.9509154307892587 0.9056797348440103 3.5767636567146783 0.9873607871834472 0.12438413167266009 0.1102115970786665 0.17072940285535013 0.09779780217269309 0.2565938164762694 1.2541981200116327e-07 6.901633854548698 2.671083921870668 up VSANKGEIGDATPFNDAVNVQK(ub)ISNLLSDYGYHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSANKGEIGDATPFNDAVNVQKISNLLSDYGYHLR 35 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 42714000.0 13151000.0 15328000.0 14235000.0 True False 17024228.744965527 14474983.325605122 11644376.06343436 1.0 0.8502578027146 0.683988463611186 24.021086104973563 -6.969775063507257 0.26352420360412043 1.0447168248387702 0.4845737892138422 0.9999805654834897 0.000568970455246471 0.07637595753628325 0.009292014997411708 0.003393493480684694 0.015606305866376477 1.0720744267798544e-07 6.969775063507257 -0.560143035624928 VSANSVYGFTGAQVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSANSVYGFTGAQVGK 16 0 P28340;M0R2B7;M0QZR8;A0A2R8Y7K6 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 12942400.0 1275900.0 2046400.0 9620100.0 False True 1672717.2558331753 1741085.0968047243 8624704.334515294 1.0 1.0408723235998993 5.156104120071001 20.673762172452516 -6.90907250966765 0.9020249491809575 0.868816612992849 5.677516432952824 0.9905668977675156 0.1893575312622513 0.10503461115343012 0.14211668638270933 0.15432209488825308 0.42331189028019023 1.2328989716265284e-07 6.90907250966765 4.808699819959974 up VSAPEVSVGHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSAPEVSVGHK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 4580970.0 438970.0 2390800.0 1751200.0 False True 575493.9209915266 2034101.959265411 1570002.6226965573 1.0 3.534532486044037 2.728095928435834 19.134441163521167 -9.986755460761747 5.6754403171592935 0.9999962152405434 3.1313142072412403 0.9030357461584795 0.3292263460157231 1.576743229325048e-05 2.813843942716484e-06 0.3187725985158669 0.10625734627029669 1.03096646580507e-10 9.986755460761747 2.131317992000697 VSAPEVSVGHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSAPEVSVGHK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 4325770.0 438970.0 1875900.0 2010900.0 False True 601269.0717182019 1793016.5352282552 1535966.835785502 1.0 2.982053492464672 2.5545415655528134 19.19765122504406 -10.094218252775077 5.146456744721627 0.9999614543004359 2.768297529012198 0.9580034024854173 0.17453101332671997 7.719360370350433e-05 1.3585841907653118e-05 0.16899257475512464 0.056329642332527116 8.049738035010234e-11 10.094218252775077 1.7683360747117622 VSDHASAMNK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSDHASAMNKR 11 1 E7ESU6;D6R9Q7;Q8NBW4-2;Q8NBW4-3;Q8NBW4;D6R9X0 E7ESU6 SLC38A9 Sodium-coupled neutral amino acid transporter 9 1 2171780.0 506720.0 558460.0 1106600.0 True False 694068.0775931105 533785.3906197399 845243.8711423923 1.0 0.7690677728196361 1.2178111894636174 19.404717650769317 -6.766845759519551 1.586742204032895 0.8670101003092588 1.2200274309246446 0.7182809337608216 0.09725063798866931 0.27155597996599656 1.3488603599411337 0.048326334195524276 0.11536281606617009 1.7106227380178078e-07 6.766845759519551 0.35301733061538576 VSDHASAMNK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSDHASAMNKR 11 1 E7ESU6;D6R9Q7;Q8NBW4-2;Q8NBW4-3;Q8NBW4;D6R9X0 E7ESU6 SLC38A9 Sodium-coupled neutral amino acid transporter 9 1 1943950.0 330560.0 757230.0 856160.0 True False 274875.28629097133 753150.6516916137 1035179.0975634257 1.0 2.7399722319683564 3.7659955230301385 18.068417676128604 -8.606039123730406 0.2331696226410134 3.0414540779816227e-19 4.658221641355439 0.9994325439443554 0.027196411282998417 0.2156229667757135 0.06554674906403116 0.58990038939956 0.4358050996630573 2.477198887339783e-09 8.606039123730406 4.658221641355439 VSDILHSIFSSYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSDILHSIFSSYK 13 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 107743000.0 21981000.0 31041000.0 54721000.0 False True 28817303.864306804 26409803.796870314 49058995.84089677 1.0 0.9164564430186536 1.7024144962312517 24.780432028053553 -6.880611790601852 1.0763497996349292 0.9477865974026475 1.7587795393257868 0.9741769160032582 0.056639875226393556 0.12709096784503274 0.2690058661472846 0.04051259719528523 0.09812646193912528 1.3164010177781868e-07 6.880611790601852 0.8109929419231393 VSDILHSIFSSYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSDILHSIFSSYK 13 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 104665000.0 37676000.0 27312000.0 39677000.0 False True 36479996.00279976 38217824.030198425 29284403.41551427 1.0 1.0476378349182192 0.8027523745689764 25.12060223563466 -6.856239947569851 1.2045228945072006 1.0256312555090246 0.7917141407341377 0.9489102869441859 0.023961688162449618 0.15072710799417488 0.41769474142216184 0.01553716947918644 0.036129898243555204 1.3923872968287152e-07 6.856239947569851 -0.23391711477488686 VSDILHSIFSSYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSDILHSIFSSYK 13 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 67645000.0 26467000.0 23887000.0 17291000.0 False True 40152373.99688252 19624178.22001714 13873426.271085465 1.0 0.4887426636726582 0.34551945227852815 25.258981953380722 -13.999999999999993 0.1785075474627706 3.640708421069183 0.22997951560728805 0.9995000138245561 0.006281460827629583 12.185786104885471 0.1339214254604225 11.157316353499338 0.10830748132226505 1.0000000000000164e-14 13.999999999999993 -3.410728905461895 VSDILHSIFSSYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSDILHSIFSSYK 13 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 151902000.0 21981000.0 35546000.0 94375000.0 False True 30107969.7141896 33975460.18509707 72085568.71413632 1.0 1.1284540441491395 2.3942354598610835 24.843642089576445 -6.926435992818564 0.7754799334713348 0.9779974063790123 2.631990022747982 0.9957904785789452 0.0408205040924317 0.09453062983578459 0.08705614137755617 0.036429564260330304 0.11685558511110622 1.184578939724171e-07 6.926435992818564 1.6539926163689698 up VSDILHSIFSSYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSDILHSIFSSYK 13 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 98358000.0 37676000.0 23828000.0 36854000.0 False True 31329263.329799827 23699633.834512286 44560001.00635681 1.0 0.7564695532425629 1.4223124411601515 24.901007511068936 -6.807724229802149 1.4241082413980584 0.8669171139611666 1.4333612523345096 0.8537955380960243 0.10517999191806468 0.20992003249465846 0.8395097266585377 0.058081536612585444 0.1344965150132206 1.5569539591781507e-07 6.807724229802149 0.5664441383733431 VSDILHSIFSSYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSDILHSIFSSYK 13 0 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 66981000.0 26467000.0 23579000.0 16935000.0 False True 34262053.24256727 22266807.922393188 13853003.76777387 1.0 0.6498970673108652 0.40432497345380514 25.03010827547317 -8.008346346184 0.17131056296316186 1.3069144181706662 5.790398247152477e-09 0.9999138321523021 0.002268937780380571 0.1038286233817042 0.029490455768320878 0.08726462304124002 0.1089080405723488 9.809653194304223e-09 8.008346346184 -1.306914412380268 down VSDYEMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSDYEMK 7 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 4737700.0 1399400.0 709700.0 2628600.0 False True 1354976.812992832 993086.9110366069 1940090.8036903224 1.0 0.7329180112264109 1.4318258328016022 20.369836733031384 -6.803112329746092 1.4430289417313895 0.8532172661267469 1.442248959907282 0.8411573487698762 0.11476587391084633 0.21633612156697624 0.8889903636055952 0.06255601119925866 0.1452246731230405 1.573575808333471e-07 6.803112329746092 0.5890316937805352 VSDYEMK(ub)LMDLDVEQLGIPEQEYSCVVK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VSDYEMKLMDLDVEQLGIPEQEYSCVVK 28 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 260854000.0 66917000.0 101627000.0 92310000.0 True False 101517981.28799582 83490867.83462484 74064888.03908975 1.0 0.8224244294000493 0.7295740823389255 26.597160045301962 -13.999999998734582 0.08181908850166664 1.9473292853119606 0.4613977419564461 0.999879056113899 0.0012338179818646006 12.240538129694192 0.08100565033221672 2.081727279176467 0.2430107502384116 1.0000000029137325e-14 13.999999998734582 -1.4859315433555145 VSDYEMK(ub)LMDLDVEQLGIPEQEYSCVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 3 VSDYEMKLMDLDVEQLGIPEQEYSCVVK 28 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 236916500.0 86795000.0 58975000.0 91146500.0 True False 112357838.48523155 55692989.406808555 74558772.24206676 1.0 0.4956751585616246 0.6635831842908482 26.743525534700833 -10.436531602487278 7.085323785454291 1.0000427835218086 0.5796291714262366 0.8931304607811095 0.06854816445911785 4.633168456774511e-05 3.684562267668782e-06 0.06637819669679777 0.022123824946937546 3.659893074928218e-11 10.436531602487278 -0.42041361209557204 VSEFK(ub)EGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSEFKEGK 8 1 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 1 4129270.0 2052600.0 1402100.0 674570.0 True False 2690978.4774066727 1192912.1453429936 604771.9673323537 1.0 0.4433005151689719 0.2247405441589334 21.35969942159465 -11.57701187658937 0.16771731223032582 2.2488717376579954 5.366376798503842e-16 0.9995278562856793 0.00709184665709155 4.346922591271986 0.104821839024155 2.141262245555814 0.17574585593631348 2.648427711440782e-12 11.57701187658937 -2.248871737657995 VSEFK(ub)EGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSEFKEGK 8 1 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 1 4118100.0 2052600.0 1424700.0 640800.0 True False 2811501.6894293022 1361752.0431471257 489456.23769026296 1.0 0.48435042677265594 0.17409067884629872 21.422909483117543 -8.510801873933202 0.2878222263879111 1.1911084442939623 3.59669207670828e-12 0.9989318851724095 0.01113259765746345 0.17350112988751928 0.0787573910781304 0.1253021888827598 0.10020911523796056 3.084594828039025e-09 8.510801873933202 -1.1911084442903657 VSEFK(ub)EGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSEFKEGK 8 1 Q15459;Q15459-2 Q15459 SF3A1 Splicing factor 3A subunit 1 1 4166870.0 2242300.0 1445700.0 478870.0 True False 1864571.8007328317 1437911.727151018 578999.5029552857 1.0 0.7711753050142003 0.31052679372696823 20.83041292265279 -6.9599169321960765 0.4366039135119826 1.0170663475002513 0.046776656636014775 0.9997671032333318 0.004375782589762119 0.07973082151002837 0.021241149834466393 0.006048752565757768 0.03819308916060811 1.0966879403393846e-07 6.9599169321960765 -0.9702896908642364 down VSELCEK(ub)AEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSELCEKAEEK 11 1 Q96HT8 Q96HT8 MRFAP1L1 MORF4 family-associated protein 1-like 1 1 5058280.0 679660.0 795020.0 3583600.0 True False 658084.5653270751 1112475.6319745304 2644947.6543044327 1.0 1.6904751920775076 4.0191607487251515 19.327913459824234 -6.948793552134643 0.5719346331954734 0.9712393890058425 4.851992480528945 0.9991031794277823 0.03868051283660741 0.08397382905452265 0.037995307840950766 0.04088978793350517 0.19411837025162074 1.1251396975193013e-07 6.948793552134643 3.8807530915231023 VSELCEK(ub)AEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSELCEKAEEK 11 1 Q96HT8 Q96HT8 MRFAP1L1 MORF4 family-associated protein 1-like 1 1 17664600.0 2512400.0 5027500.0 10124700.0 True False 3811494.4810430976 4130303.344963215 8123548.607186343 1.0 1.0836440576014867 2.1313289701952183 21.861925356448662 -6.922782252842324 0.8038014205906899 0.9791205533436419 2.311597252564902 0.9949201339875308 0.03668661584270637 0.09656154544162487 0.09732592955380694 0.03208463378830048 0.09882430804054193 1.1945868979424863e-07 6.922782252842324 1.3324766992212598 up VSELCEK(ub)AEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSELCEKAEEK 11 1 Q96HT8 Q96HT8 MRFAP1L1 MORF4 family-associated protein 1-like 1 1 28754000.0 2512400.0 5372400.0 20869200.0 True False 3252351.326807951 5073421.217280845 17071219.736074757 1.0 1.5599241002847621 5.248885504884694 21.63305167854111 -6.933888950197748 0.714146989597204 0.9511805942726139 6.087110623265597 0.997248924732252 0.09886330314276408 0.0906681589004656 0.06815190008641255 0.09225182093119676 0.3269438558700832 1.1644237363816734e-07 6.933888950197748 5.135930028992983 up VSELHLEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSELHLEVK 9 0 A0A0U1RR22;Q9UNF0-2;Q9UNF0;B0QYG7;B0QYG8 A0A0U1RR22 PACSIN2 Protein kinase C and casein kinase substrate in neurons protein 2 0 5076700.0 1277400.0 1743000.0 2056300.0 False True 1674683.770359196 1482951.1941607862 1843533.8014224146 1.0 0.885511175547318 1.1008250238353972 20.675457267279047 -6.762276529551053 1.6041215024781963 0.9336853546964364 1.1016949658268318 0.700086851887928 0.048170969682446635 0.27912099114589023 1.41609961215621 0.023688849495412882 0.05679579338829664 1.728715278947285e-07 6.762276529551053 0.16800961113039536 VSEWEVIQESGTK(ub)LKPMYGPGYTGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSEWEVIQESGTKLKPMYGPGYTGLK 26 2 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 32227000.0 11541000.0 10177000.0 10509000.0 True False 11174637.272223994 14240729.172353907 7756377.636757819 1.0 1.2743795458803016 0.6941055398762068 23.41372466662176 -6.778108433873794 1.5430568569812448 1.1557426297698032 0.6897639861463002 0.7606942703493211 0.11594377459731521 0.25352819439594887 1.1921764450700456 0.059186770536716435 0.13988905828947945 1.6668309891955577e-07 6.778108433873794 -0.46597864362350305 VSEWEVIQESGTK(ub)LKPMYGPGYTGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSEWEVIQESGTKLKPMYGPGYTGLK 26 2 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 12125600.0 2280500.0 6142300.0 3702800.0 True False 3123662.478195228 5870912.876130122 2828274.9015597748 1.0 1.879496558002702 0.9054355012113471 21.574807143373604 -6.66888107441587 1.941517066980315 1.5619191815404996 0.9094050174508502 0.27406195292029334 0.37368753920236486 0.46366741697397645 3.3685478501372654 0.15501679047411135 0.4147444073218316 2.1434774826557632e-07 6.66888107441587 -0.6525141640896494 VSEWEVIQESGTK(ub)LKPMYGPGYTGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSEWEVIQESGTKLKPMYGPGYTGLK 26 2 Q92995;Q92995-2 Q92995 USP13 Ubiquitin carboxyl-terminal hydrolase 13 1 26312300.0 11541000.0 11275000.0 3496300.0 True False 9596852.852989148 11214259.33708774 4227360.164935297 1.0 1.1685350925845253 0.440494423504534 23.194129942056037 -6.845774297581382 1.2553817499988706 1.0897065705047129 0.41368931143508364 0.9339171545433925 0.07999360302507941 0.16216737350548155 0.4939526082163697 0.04991212400444066 0.11522534908777708 1.4263486730304398e-07 6.845774297581382 -0.6760172590696292 down VSFCPLSLWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSFCPLSLWR 10 0 O96005-3;O96005-4;O96005 O96005-3 CLPTM1 Cleft lip and palate transmembrane protein 1 0 5467500.0 1613100.0 2121700.0 1732700.0 False True 2114789.7212826186 1805150.6303218235 1553416.825232028 1.0 0.8535839814972246 0.734549071048956 21.01208278910222 -6.973483526059439 0.15365282081844453 1.1315021327320702 0.45349028703263533 0.9999983789693947 0.0001381000405495155 0.07518761905192183 0.004713184679225371 0.005859149636161488 0.01463374450131637 1.0629589033589608e-07 6.973483526059439 -0.6780118456994348 VSFCPLSLWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSFCPLSLWR 10 0 O96005-3;O96005-4;O96005 O96005-3 CLPTM1 Cleft lip and palate transmembrane protein 1 0 5252200.0 1613100.0 1582600.0 2056500.0 False True 2209506.662388389 1512675.4990416518 1570797.0549469788 1.0 0.6846213794198338 0.7109265980891 21.07529285062511 -9.924727813608595 5.17332577116655 1.0000008271771386 0.6977739887505627 0.9943503573595305 0.010739060565620854 1.0246091049952937e-07 2.1294830315721885e-08 0.010398079028845559 0.0034660168917554834 1.1892473336707923e-10 9.924727813608595 -0.30222683842657583 VSFELFADK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSFELFADK 9 0 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 969940000.0 233720000.0 279040000.0 457180000.0 False True 306409183.3476994 237408319.68940085 409875399.1802268 1.0 0.774808108215218 1.3376733513731491 28.19088429582536 -6.79813559734131 1.4635033175184924 0.8754520231578405 1.3450898249280812 0.8266322995293001 0.09631289063058676 0.22344611852943683 0.9450279799048739 0.05177661094157408 0.12055315833717069 1.5917116782094525e-07 6.79813559734131 0.4696378017702406 VSFELFADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSFELFADK 9 0 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 976410000.0 371250000.0 212680000.0 392480000.0 False True 359464871.9619758 297604233.11154824 289677713.8523839 1.0 0.827909084654672 0.8058581976906661 28.421275551954206 -13.999999999999948 0.2896813838968702 2.4802439623180756 0.7998299439985416 0.9996267451972243 0.0016767561367365025 15.946611519573024 0.17067114697653132 14.064320762929539 0.008339963741214637 1.0000000000001186e-14 13.999999999999948 -1.6804140183195342 VSFELFADK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSFELFADK 9 0 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 842500000.0 177080000.0 470420000.0 195000000.0 False True 268643306.28208554 386469875.59176415 156458164.52846375 1.0 1.438598567521933 0.5824011277026825 28.001116650321112 -6.767468605048537 1.5841154134446496 1.2523892095121791 0.5780397850553655 0.7207440970374945 0.18473237701947967 0.2705699056017664 1.339578913583517 0.09193946294412736 0.21936876063650537 1.708171198519094e-07 6.767468605048537 -0.6743494244568137 VSFELFADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSFELFADK 9 0 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 915840000.0 233720000.0 289130000.0 392990000.0 False True 320132600.0455114 276355280.5749481 300173855.88310874 1.0 0.8632525414020947 0.9376547588106764 28.25409435734825 -10.153204820978788 4.369311533713734 1.0000197100209358 0.9004536501020862 0.7047368070773661 0.030374578079793737 5.879285462743621e-06 1.139416665733122e-06 0.029415926963974166 0.009803352918688795 7.027408166880912e-11 10.153204820978788 -0.09956605991884959 VSFELFADK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSFELFADK 9 0 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 783680000.0 371250000.0 185630000.0 226800000.0 False True 308710824.1636102 184629974.3453299 274222831.3952826 1.0 0.5980677057422513 0.8882838239904096 28.201680827388483 -9.93401950945644 6.3203297722523955 1.0000000470205574 0.743175764866313 0.5108018666446587 0.11848023413993158 7.838179055728209e-08 1.3523281058281849e-08 0.11471801393277357 0.038239331139883315 1.1640737355018832e-10 9.93401950945644 -0.25682428215424447 VSFELFADK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSFELFADK 9 0 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 610160000.0 177080000.0 286800000.0 146280000.0 False True 229233550.76864827 270839327.88253844 119658540.95954886 1.0 1.181499509885795 0.5219940124746969 27.77224297241356 -6.833320857192319 1.3128844895900786 1.0967853838756798 0.5029979695255307 0.9123674878701321 0.0823444438827084 0.17675553375658318 0.5946465156003872 0.04922556645237185 0.11329218501292916 1.4678414342496534e-07 6.833320857192319 -0.5937874143501491 VSFELFADK(ub)VPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSFELFADKVPK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 38954800.0 17731800.0 17058600.0 4164400.0 True False 23246561.514995467 14513523.373902 3733507.8357455153 1.0 0.6243298977588527 0.16060473431036984 24.47051400184628 -7.524203520607991 0.4363946055202354 1.0280065562927856 1.3059113920680924e-22 0.9983009474918968 0.01415107194875374 0.11843283917138696 0.05757382668558225 0.020569741180250328 0.06838756706503508 2.990862719538472e-08 7.524203520607991 -1.0280065562927856 down VSFELFADK(ub)VPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSFELFADKVPK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 74085800.0 36735600.0 24674200.0 12676000.0 True False 35569448.486050814 34526736.73425319 9355775.328151306 1.0 0.9706851864119698 0.2630284057347793 25.08413526940669 -6.9156119569675 0.8566463233701047 1.0182170760364728 0.1596875463995662 0.9928723935403106 0.028764698026547315 0.10082315938972078 0.11950484100350607 0.024224058427891406 0.06977852237528599 1.2144735004498617e-07 6.9156119569675 -0.8585295296369067 down VSFELFADK(ub)VPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSFELFADKVPK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 73176100.0 30003700.0 20453200.0 22719200.0 True False 45517806.46428629 16803166.658419017 18228740.161820907 1.0 0.36915589664020704 0.400474925700195 25.439927699023272 -10.12583434903753 5.92131281590826 1.0000041001252669 0.38481541117018275 0.998059902103919 0.012785940072793035 35691537.84399352 0.01646456678468352 1995.280158545764 0.004376967372976181 7.484549258204799e-11 10.12583434903753 -0.6151886889550842 VSFELFADK(ub)VPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSFELFADKVPK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 42070800.0 17731800.0 17524600.0 6814400.0 True False 24287725.64387731 16750305.225897478 5204979.066973348 1.0 0.6896613322919374 0.2143049185951864 24.53372406336917 -7.255890589032167 0.4323144565291482 1.022606500156508 4.300862136981595e-15 0.9993951536933184 0.00794640090462917 0.09567994165544887 0.03325649899233979 0.01098776738692009 0.04988838002972064 5.5476545634166796e-08 7.255890589032167 -1.0226065001565037 down VSFELFADK(ub)VPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSFELFADKVPK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 72258200.0 36735600.0 32523500.0 2999100.0 True False 30547279.063016098 32348289.4500907 3626197.94372836 1.0 1.058958127935365 0.11870772307569072 24.864540544840967 -6.891956669427482 1.010706394159925 1.0481763740759864 0.03465868454306855 0.9821224105744918 0.05749617816620811 0.11757109269943518 0.21267502720669407 0.04322887736403968 0.10856100022410145 1.2824585301492373e-07 6.891956669427482 -1.0135176895329179 down VSFELFADK(ub)VPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSFELFADKVPK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 51743100.0 30003700.0 7551400.0 14188000.0 True False 38840381.11134684 7131157.951785913 11605929.58117363 1.0 0.18360164724806508 0.2988109088811971 25.21105402111572 -10.790274862005758 7.259749722057834 1.022780944009481 0.24120627806463182 0.9830041092095647 0.047033984107330076 0.015599704746969098 0.0004506554433570105 0.040964416647608505 0.015180153096122797 1.6207839895887596e-11 10.790274862005758 -0.7815746659448493 VSFELFADKVPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSFELFADKVPK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 1164285000.0 344235000.0 395330000.0 424720000.0 False True 451295418.57648146 336348304.9842706 380774048.60192055 1.0 0.7452951905543648 0.8437356838298823 28.7494968918914 -10.44615770068162 6.837409980715192 1.0000335684126707 0.794515437250383 0.8531494583328014 0.040188163092149426 2.0568150780943195e-05 1.6660787902213494e-06 0.03891836767747203 0.01297067386421353 3.5796642900268e-11 10.44615770068162 -0.20551813116228768 VSFELFADKVPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSFELFADKVPK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 1070932000.0 417680000.0 194312000.0 458940000.0 False True 404420977.02647275 271901794.92369366 338729846.0951209 1.0 0.6723236685764087 0.8375674491111973 28.59128258983928 -10.126552062635481 4.879836605466952 1.0000133961299653 0.7549455588425873 0.7456981927164128 0.06746049091731064 9.832397559241687e-06 1.7600042282706056e-06 0.06532190822585456 0.021772779820211863 7.472190532118319e-11 10.126552062635481 -0.24506783728737802 VSFELFADKVPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSFELFADKVPK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 2525960000.0 444380000.0 1354170000.0 727410000.0 False True 674156948.5296655 1112507783.321498 583637094.664871 1.0 1.6502207471833887 0.8657288127605626 29.32850925926902 -6.686658210718907 1.8784244510136607 1.4089255577823854 0.8685561439304389 0.35473366821745766 0.27518847738406693 0.4239129780760496 2.897377095742132 0.11731672305265281 0.30677889279957077 2.0575092164718143e-07 6.686658210718907 -0.5403694138519465 VSFELFADKVPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSFELFADKVPK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 1499645000.0 344235000.0 653330000.0 502080000.0 False True 471507982.10108924 624463720.3266032 383499044.6621837 1.0 1.3243969222831118 0.8133458164446582 28.812706953414292 -6.735164893800539 1.7044543922899105 1.1940759121600906 0.813349562647385 0.5831747038111872 0.1363205540458636 0.32655821338532504 1.860820619715311 0.06332344806775266 0.15621907207180796 1.8400732261255286e-07 6.735164893800539 -0.38072634951270556 VSFELFADKVPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSFELFADKVPK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 860747000.0 417680000.0 173276000.0 269791000.0 False True 347319426.3613648 172342527.79540712 326203050.7273576 1.0 0.4962075677739234 0.9392018584873602 28.371687865273557 -10.275401949582694 8.182745886512947 1.0000003322782474 0.7177047131306421 0.3512556513287388 0.1808516618690121 1.0962572878823605e-06 9.725905303895211e-08 0.17510907215880864 0.05836962287938489 5.303933257110954e-11 10.275401949582694 -0.28229561914760526 VSFELFADKVPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSFELFADKVPK 12 1 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 0 1950550000.0 444380000.0 862390000.0 643780000.0 False True 575258670.0393716 814397238.3982631 526618645.74062365 1.0 1.4157061524036212 0.9154466906245516 29.09963558136147 -6.686094471518842 1.8800697651141787 1.2615639719103602 0.9172412898088431 0.3523253963317614 0.17595543141645612 0.42510955793894656 2.910095952330203 0.07495335336908666 0.19616621445173574 2.0601817158507914e-07 6.686094471518842 -0.34432268210151706 VSFELFADKVPK(ub)TAENFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSFELFADKVPKTAENFR 18 2 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 11400200.0 2809800.0 5206200.0 3384200.0 True False 3683675.0101419105 4429455.253608658 3034035.4475386543 1.0 1.2024554938786571 0.8236436274061458 21.81271435552582 -6.761493392641518 1.6066077640522642 1.1173756562688435 0.8221441287750391 0.6971542231873532 0.08517301605179754 0.28040121595073647 1.426764513787661 0.0418200311962532 0.10036215525477751 1.7318353787020458e-07 6.761493392641518 -0.29523152749380444 VSFELFADKVPK(ub)TAENFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSFELFADKVPKTAENFR 18 2 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 20762100.0 6553700.0 6008200.0 8200200.0 True False 6345656.380814004 8407305.592349082 6052321.619273133 1.0 1.3248914041057194 0.9537739291355636 22.597337970327988 -6.675375776602108 1.9182477916265508 1.206399171481052 0.9552270096578056 0.3032804266939032 0.13783586753098415 0.44878227848890856 3.188573707359379 0.05774302467083722 0.15320541332649548 2.111661118303075e-07 6.675375776602108 -0.2511721618232464 VSFELFADKVPK(ub)TAENFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSFELFADKVPKTAENFR 18 2 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 59458000.0 13663000.0 18395000.0 27400000.0 True False 20727769.8990972 15112268.529209023 21984377.990153365 1.0 0.729083186603072 1.0606243747963884 24.305061569439154 -6.689476904783861 1.8682306570646616 0.830069195194816 1.0594725893037353 0.3679916026254031 0.11459094009810283 0.4177975031757834 2.8268381781578933 0.04907545303990036 0.12788228328741097 2.0441986409390478e-07 6.689476904783861 0.2294033941089193 VSFELFADKVPK(ub)TAENFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSFELFADKVPKTAENFR 18 2 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 14781600.0 2809800.0 5793500.0 6178300.0 True False 3848658.9919899013 5537524.013457483 4719112.786082635 1.0 1.438819086071945 1.226170672929034 21.87592441704871 -10.054561984265595 4.220950927943464 0.9999671032144405 1.332494879412766 0.765244467099925 0.08681335142643759 60633296.09000908 126632715.99241422 29257.267582461198 0.031770439062138334 8.819379194054983e-11 10.054561984265595 0.3325277761983255 VSFELFADKVPK(ub)TAENFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSFELFADKVPKTAENFR 18 2 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 18598900.0 6553700.0 8207500.0 3837700.0 True False 5449691.92813751 8163284.568438814 4640145.326480043 1.0 1.4979350532257891 0.8514509421206607 22.377743245762264 -6.70098481715433 1.8272587318864602 1.3089008798825648 0.8533340199654901 0.42225624601914036 0.2101474537381714 0.39350053991643985 2.5549682949575794 0.09172423741029924 0.23561283793048038 1.9907429337337575e-07 6.70098481715433 -0.4555668599170747 VSFELFADKVPK(ub)TAENFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSFELFADKVPKTAENFR 18 2 P62937;F8WE65;C9J5S7 P62937 PPIA Peptidyl-prolyl cis-trans isomerase A;Peptidyl-prolyl cis-trans isomerase A, N-terminally processed;Peptidyl-prolyl cis-trans isomerase 1 71892000.0 13663000.0 21498000.0 36731000.0 True False 17687022.83799435 20301617.40173923 30046334.891886707 1.0 1.1478255887208073 1.6987785432912272 24.076187891531603 -6.946500850417158 0.596032682471145 0.9937361917930555 1.880879424345245 0.9988972067935576 0.009985182521214544 0.08492219549247998 0.042018916127894775 0.010288721807832501 0.04624171127174497 1.1310951744686177e-07 6.946500850417158 0.8871432325521894 VSFGVSEQQAVEAWEK(ub)LTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSFGVSEQQAVEAWEKLTR 19 1 Q9Y3T9 Q9Y3T9 NOC2L Nucleolar complex protein 2 homolog 1 5436800.0 0.0 1673000.0 3763800.0 True False 0.0 2341037.624579743 2777947.8684203075 0.0 VSFLLPTLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSFLLPTLR 9 0 Q9UFC0;H7C5S6 Q9UFC0 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 0 14811600.0 4433200.0 4093900.0 6284500.0 False True 5811968.131169866 3483106.077897216 5634240.2251807405 1.0 0.5992988948471947 0.969420357789651 22.470595361570695 -10.4571818532499 8.744775007449695 1.0000038628469554 0.7843596278993445 0.31157716170104977 0.15110145451024182 1.137974910856181e-05 7.064224924904986e-07 0.1463059727553077 0.04876778474215701 3.4899414965702153e-11 10.4571818532499 -0.21564423494761087 VSFLLPTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSFLLPTLR 9 0 Q9UFC0;H7C5S6 Q9UFC0 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 0 12554000.0 4330900.0 1514900.0 6708200.0 False True 4193417.9501148 2119807.470099136 4951121.178313701 1.0 0.5055082739942732 1.1806886976715876 21.99969519738787 -6.710393817348124 1.793587940555998 0.6961124288668025 1.1791314583767767 0.4669540787754629 0.20836492826850467 0.37434505469357776 2.3476821091653943 0.0924353365752175 0.234735845481633 1.948077286081435e-07 6.710393817348124 0.4830190295099742 VSFLLPTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSFLLPTLR 9 0 Q9UFC0;H7C5S6 Q9UFC0 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 0 13763200.0 4433200.0 4008900.0 5321100.0 False True 6072273.842725318 3831773.542340502 4064365.7714944663 1.0 0.6310277898502599 0.6693317654577852 22.533805423093586 -9.947427264643736 7.032787197249315 1.0000000138459821 0.6501797779935033 0.9910880763906477 0.01563753255974457 3.40215819030419e-09 5.132943947675095e-10 0.01514097647176906 0.005046991931638486 1.1286849531182097e-10 9.947427264643736 -0.3498202358524788 VSFLLPTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSFLLPTLR 9 0 Q9UFC0;H7C5S6 Q9UFC0 LRWD1 Leucine-rich repeat and WD repeat-containing protein 1 0 10153400.0 4330900.0 2463500.0 3359000.0 False True 3601335.2414011536 2450228.6365335374 4061351.3697387744 1.0 0.680366717423463 1.1277348809544996 21.780100472822145 -6.7148912457843295 1.7777259893648354 0.8044850382680403 1.1268443828180223 0.4882944191450339 0.13459386869025255 0.365339221297354 2.2535314703430793 0.060183061331120356 0.1519957830892205 1.9280076563938528e-07 6.7148912457843295 0.32235934454998205 VSFSFSLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSFSFSLTK 9 0 Q9BYW2;C9JG86;Q9BYW2-3;Q9BYW2-2 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 0 3035620.0 0.0 836220.0 2199400.0 False True 0.0 831715.1168833259 2659284.3711233884 0.0 VSFSFSLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSFSFSLTK 9 0 Q9BYW2;C9JG86;Q9BYW2-3;Q9BYW2-2 Q9BYW2 SETD2 Histone-lysine N-methyltransferase SETD2 0 23787100.0 9304500.0 8016600.0 6466000.0 False True 12044858.669115009 7570469.162842239 5289254.346762674 1.0 0.6285228719415499 0.4391296313276958 23.521914129721242 -12.659485219417398 0.09887269335085049 2.458482317903012 6.913937451236197e-21 0.9998413162116982 0.0029346078491621816 7.4488047991564965 0.07956395870351178 2.5388137761141927 0.34953828100914514 2.190356372401232e-13 12.659485219417398 -2.458482317903012 VSFSK(ub)STI ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSFSKSTI 8 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;Q9UKA9;Q9UKA9-2;Q9UKA9-4;Q9UKA9-3;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 O95758-1;P26599 PTBP3;PTBP2;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 2;Polypyrimidine tract-binding protein 1 1 12542200.0 3157400.0 4667600.0 4717200.0 True False 4139381.9763050913 3971212.2741623004 4229109.394577555 1.0 0.9593732341916165 1.0216765253330298 21.980983953889982 -6.730754526191099 1.720441878433889 0.975570674789451 1.0216444988819873 0.5626835487560293 0.017077664099385114 0.33487258395486313 1.9421810988577703 0.007864997671107104 0.019500072863235365 1.8588548281961055e-07 6.730754526191099 0.04607382409253624 VSFSK(ub)STI ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSFSKSTI 8 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;Q9UKA9;Q9UKA9-2;Q9UKA9-4;Q9UKA9-3;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 O95758-1;P26599 PTBP3;PTBP2;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 2;Polypyrimidine tract-binding protein 1 1 43334700.0 6716700.0 4599000.0 32019000.0 True False 10189724.956544418 3778272.517848997 25690430.615573738 1.0 0.37079239468798186 2.521209426666015 23.280611774676533 -6.828375661376585 1.3351104788543675 0.6633938179056701 2.577196249198353 0.9025948822766232 0.2817397926698588 0.18282392814270543 0.6379144022655114 0.16571284918037588 0.38139348670937256 1.4846508751562604e-07 6.828375661376585 1.913802431292683 up VSFSK(ub)STI ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSFSKSTI 8 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;Q9UKA9;Q9UKA9-2;Q9UKA9-4;Q9UKA9-3;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 O95758-1;P26599 PTBP3;PTBP2;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 2;Polypyrimidine tract-binding protein 1 1 14495500.0 3157400.0 6823700.0 4514400.0 True False 4324776.1055266885 6522206.371041654 3448191.6969864545 1.0 1.5081026651777047 0.7973110313340764 22.044194015412874 -6.714817502077019 1.7781259739367663 1.3108285898905792 0.7987415054836817 0.4878578018807088 0.21395899061100362 0.365498154768849 2.2555123036042453 0.09565355793299192 0.24158750499732579 1.9283350621287746e-07 6.714817502077019 -0.5120870844068974 VSFSK(ub)STI ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSFSKSTI 8 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;Q9UKA9;Q9UKA9-2;Q9UKA9-4;Q9UKA9-3;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 O95758-1;P26599 PTBP3;PTBP2;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 2;Polypyrimidine tract-binding protein 1 1 20655000.0 6186100.0 9713000.0 4755900.0 True False 5144016.240696317 9660674.141120454 5750336.701202925 1.0 1.8780411431618542 1.1178690797493545 22.29446376687632 -10.2149037278375 4.371546286918582 0.9998312377791908 1.497955111460276 0.36392060285555794 0.3103389455153855 218480330.42576292 134.87068437072412 404907.2578681066 0.1062372755555 6.096720312154922e-11 10.2149037278375 0.49812387368108524 VSFSK(ub)STI ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSFSKSTI 8 1 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-7;Q9UKA9;Q9UKA9-2;Q9UKA9-4;Q9UKA9-3;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 O95758-1;P26599 PTBP3;PTBP2;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 2;Polypyrimidine tract-binding protein 1 1 23344900.0 6716700.0 4926200.0 11702000.0 True False 8694900.555950876 4652052.639522171 9572356.072659569 1.0 0.535032299632025 1.1009161072127678 23.051738096768982 -6.688307488667827 1.8718699349029175 0.7080527509785124 1.098955871362071 0.36285460450327645 0.1967135275773317 0.42026610836626366 2.853570034183282 0.08410132390813843 0.21951933481107744 2.0497104313872365e-07 6.688307488667827 0.3909031203835587 VSFTGK(ub)QGEMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSFTGKQGEMR 11 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 10584700.0 3734300.0 4775500.0 2074900.0 True False 4895703.4630126385 4063014.0147532006 1860209.2518462131 1.0 0.8299142391792188 0.3799677137106478 22.223084744716395 -6.9542394632709845 0.5101890058726677 1.0082680428524278 0.18186790753853183 0.9994933258417448 0.005888032367162311 0.0818268415966224 0.029253550418001605 0.006779649651576674 0.03713559784395199 1.1111189045404553e-07 6.9542394632709845 -0.8264001353138959 down VSFTGK(ub)QGEMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 VSFTGKQGEMR 11 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 18871600.0 7867800.0 6244200.0 4759600.0 True False 7618040.995615982 8737541.623072838 3512917.975060657 1.0 1.146953872800252 0.4611314085973369 22.86098862094461 -6.850657719435026 1.231923570753839 1.0784653863130234 0.4333666373319199 0.9412560115352631 0.07145863044139489 0.1567347003985159 0.4574055004647267 0.04538187490521307 0.10506071495719085 1.4103999391851324e-07 6.850657719435026 -0.6450987489811035 down VSFTGK(ub)QGEMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSFTGKQGEMR 11 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 18111300.0 8291500.0 4186600.0 5633200.0 True False 12578811.689845905 3439468.5199449034 4519795.550880729 1.0 0.2734335010930622 0.3593181663200571 23.58449230263372 -10.644275464982183 6.651117534691095 1.0029434164585282 0.3163758337214038 0.9883010476604065 0.03506226775598185 0.0015338059429374738 8.203307357650088e-05 0.03402576210378268 0.011316298258265245 2.2684255749625713e-11 10.644275464982183 -0.6865675827371245 VSFTGK(ub)QGEMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSFTGKQGEMR 11 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 11104100.0 3734300.0 4747500.0 2622300.0 True False 5114971.625662987 4537739.752116928 2002966.7479637598 1.0 0.8871485678141489 0.39158902425077313 22.286294806239287 -6.94273770130649 0.6335891523433205 1.0054084993623587 0.24645664799474823 0.9985008712833853 0.010231596220808662 0.08653975245592851 0.0490879507245014 0.010179858768614351 0.04216442261117367 1.1409386666028338e-07 6.94273770130649 -0.7589518513676105 down VSFTGK(ub)QGEMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSFTGKQGEMR 11 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 19517100.0 6090700.0 11400000.0 2026400.0 True False 5064686.913759735 11338585.937277157 2450110.870985008 1.0 2.238753575561107 0.4837635401170701 22.2720416573186 -6.71703148842972 1.769650802486537 1.7560148607750847 0.4868841133839183 0.4985872892664823 0.5214718172505681 0.3611391915528419 2.2085562213468415 0.23410667222775275 0.5898340633074476 1.9185296330413707e-07 6.71703148842972 -1.2691307473911664 VSFTGK(ub)QGEMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSFTGKQGEMR 11 1 Q9UQE7 Q9UQE7 SMC3 Structural maintenance of chromosomes protein 3 1 17417000.0 8291500.0 6833700.0 2291800.0 True False 10733510.19989975 6453398.5876949085 1874715.915853801 1.0 0.6012384082660286 0.17466009543376693 23.35561862472617 -7.62056506860765 0.3960873482807063 1.0439282682936633 4.503171254738683e-21 0.9986024462005337 0.012598639383178076 0.1210641229257275 0.05676481842221366 0.024716717673307076 0.07261908586767891 2.3957137826273683e-08 7.62056506860765 -1.0439282682936633 down VSFTGSVPTGMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSFTGSVPTGMK 12 0 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 25312700.0 10129000.0 6021800.0 9161900.0 False True 13279217.089375546 5123370.912792557 8213914.475150518 1.0 0.3858187480715012 0.6185541225711505 23.66266675558229 -10.223973773092133 5.490917811552339 1.000027287923868 0.5021864353213078 0.8591598209374145 0.0950138187700736 3.1741524541956535e-05 4.486118089187377e-06 0.09200176543955131 0.030665578146320625 5.970713424466649e-11 10.223973773092133 -0.4978408526025603 VSFTGSVPTGMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSFTGSVPTGMK 12 0 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 12389600.0 2899500.0 2505100.0 6985000.0 False True 2807456.959606056 3505399.4939239235 5155418.954491709 1.0 1.2486031110574187 1.8363305399400034 21.420832474536383 -6.956648073489825 0.48035199774292 0.9859395091518368 2.1235125023378822 0.9996249617071749 0.006790888556060739 0.08092099699711251 0.02572637024811153 0.0082927117896995 0.04848191826245007 1.104973662379413e-07 6.956648073489825 1.1375729931860454 VSFTGSVPTGMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSFTGSVPTGMK 12 0 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 25450500.0 10129000.0 5594200.0 9727300.0 False True 13873965.025932701 5347029.746454447 7429912.080031979 1.0 0.38540026131390537 0.5355291054968253 23.72587681710518 -10.273665089004139 8.45920203888011 1.0000003870847987 0.46046468340599483 0.9451172954645046 0.06128984398699273 4.4741007540167776e-07 3.8364677690634454e-08 0.05934367870581234 0.019781212087772792 5.325187586997776e-11 10.273665089004139 -0.5395357036788038 VSFTGSVPTGMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSFTGSVPTGMK 12 0 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 7704400.0 2899500.0 2872700.0 1932200.0 False True 2411062.7196293264 2857224.1949136946 2336214.0865165964 1.0 1.1850476437846298 0.9689561650539571 21.20123774997066 -6.679995921273014 1.9013649793776028 1.1170870735323293 0.9697712408674569 0.32407267174539356 0.07842881913002077 0.43869241035290557 3.0661401270339237 0.03309387187364972 0.08730048687179157 2.0893157528130592e-07 6.679995921273014 -0.14731583266487236 VSFYQLSHFLQCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSFYQLSHFLQCK 13 0 P16615;P16615-5;P16615-2;P16615-3;P16615-4;H7C5W9 P16615 ATP2A2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0 16240500.0 2661300.0 7120900.0 6458300.0 False True 3488990.0720658624 6058489.477050798 5790057.068388064 1.0 1.736459362712807 1.6595223685918141 21.734378061668234 -10.213677709632151 4.68479493324415 0.9998554257139453 1.6979908656558538 0.990969897261025 0.03140939633546423 22109734.53993456 9.01032613692522 34481.125150169086 0.010752271804773004 6.113955738598853e-11 10.213677709632151 0.6981354399419085 VSFYQLSHFLQCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSFYQLSHFLQCK 13 0 P16615;P16615-5;P16615-2;P16615-3;P16615-4;H7C5W9 P16615 ATP2A2 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 0 22205800.0 2661300.0 8468500.0 11076000.0 False True 3645254.528928293 8094333.66841541 8460076.917380389 1.0 2.2205126155607986 2.3208466926636415 21.797588123191126 -10.744429501957233 0.4704012532634167 1.1059281220720449e-24 2.3198462484480222 0.9996338621869195 0.011488546774416004 2.3167441256015664 0.22597860076171614 2.6582740323834204 0.021609031714496768 1.80123550120403e-11 10.744429501957233 2.3198462484480222 VSGDDVIIGK(ub)TVTLPENEDELESTNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSGDDVIIGKTVTLPENEDELESTNR 26 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 88537400.0 9913400.0 19431000.0 59193000.0 True False 15039352.56661864 15963386.23490405 47493477.604786396 1.0 1.0614410536751693 3.1579469524640946 23.842239125573272 -6.913162542252118 0.873911954656929 0.9413988973798714 3.448054411370401 0.9920615034385972 0.08937425074203045 0.10236393377358077 0.12769482982645816 0.07433583536701086 0.209990754861802 1.221342465985185e-07 6.913162542252118 2.5066555139905295 up VSGDDVIIGK(ub)TVTLPENEDELESTNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSGDDVIIGKTVTLPENEDELESTNR 26 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 70370400.0 9913400.0 11457000.0 49000000.0 True False 12833091.722328437 10819407.87848758 40082502.78245755 1.0 0.8430866164279628 3.123370708300757 23.61336544766572 -6.890408065718176 1.0199431608558942 0.8786738743246935 3.321088067609845 0.9811589779440341 0.1427429912230745 0.11881356854709864 0.21990778852119452 0.106576643524219 0.2660963543651514 1.2870396731274248e-07 6.890408065718176 2.4424141932851513 up VSGDDVIIGK(ub)TVTLPENEDELESTNRR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSGDDVIIGKTVTLPENEDELESTNRR 27 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 13950100.0 2876200.0 2359400.0 8714500.0 True False 2784896.6053522793 3301520.7241084552 6431911.0206038635 1.0 1.185509263705977 2.309569054823222 21.40919233505302 -6.935627457251797 0.6990624636798577 0.985937920434011 2.5772991264940486 0.9975331963966392 0.02873677562907495 0.0898192390754038 0.0641261719572952 0.027120605723828906 0.09875167813766768 1.1597717950159087e-07 6.935627457251797 1.5913612060600375 up VSGDDVIIGK(ub)TVTLPENEDELESTNRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSGDDVIIGKTVTLPENEDELESTNRR 27 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 169279000.0 13437000.0 23923000.0 131919000.0 True False 20384911.37628409 19653753.738747872 105845151.82784827 1.0 0.9641324102891686 5.192328280170453 24.28099834891274 -6.904985469851636 0.929194897711498 0.8474330028930974 5.683991314229907 0.9888879213376452 0.20922440710475754 0.1078287694098761 0.15744023952384145 0.16715628107706232 0.4468747077991149 1.2445562500726016e-07 6.904985469851636 4.836558311336809 up VSGDDVIIGK(ub)TVTLPENEDELESTNRR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSGDDVIIGKTVTLPENEDELESTNRR 27 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 15496700.0 2876200.0 4360600.0 8259900.0 True False 2391687.737264309 4337108.582288668 9987006.900537455 1.0 1.8134092150548025 4.175715226085877 21.189597610487297 -6.952177881505449 0.5343991306647643 0.9638806739618015 5.133293739315078 0.9993613013154445 0.034039550956774835 0.08262282195866465 0.03243289497865436 0.03773447113579353 0.19546699728519354 1.1164058884460263e-07 6.952177881505449 4.169413065353276 VSGDDVIIGK(ub)TVTLPENEDELESTNRR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSGDDVIIGKTVTLPENEDELESTNRR 27 2 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 153956000.0 13437000.0 15490000.0 125029000.0 True False 17394461.38286836 14627967.88319566 102275004.9058753 1.0 0.8409554950406574 5.879745434751143 24.05212467100519 -6.899613175922823 0.9637327052393931 0.7882762175186186 6.404473882246873 0.9863722236443511 0.2730179676303647 0.11168980345279168 0.17903992050333029 0.2126293855897111 0.5521459083038642 1.2600472303342453e-07 6.899613175922823 5.616197664728254 up VSGDMQK(ub)QGCDCECLGGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSGDMQKQGCDCECLGGGR 19 1 Q9NRX4;Q9NRX4-2 Q9NRX4 PHPT1 14 kDa phosphohistidine phosphatase 1 3380000.0 1047900.0 1109600.0 1222500.0 True False 1373807.0478780367 944052.0051869242 1096007.4270480492 1.0 0.6871794744721202 0.7977884730908369 20.38974796022162 -10.34487165958339 4.93296321305797 1.0001510359247345 0.7424839737813962 0.8784510445429466 0.04515593459629586 7.505127680486425e-05 9.96715194052736e-06 0.04374755896704101 0.014574015222783072 4.5198949419437255e-11 10.34487165958339 -0.25766706214333834 VSGDMQK(ub)QGCDCECLGGGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSGDMQKQGCDCECLGGGR 19 1 Q9NRX4;Q9NRX4-2 Q9NRX4 PHPT1 14 kDa phosphohistidine phosphatase 1 16158800.0 2281800.0 0.0 13877000.0 True False 3461657.42192491 0.0 11134204.86749483 1.0 0.0 3.2164375356656403 21.72303152680027 -6.823185368510287 1.3580572905180641 0.4626672488357592 3.291565911144823 0.891553607371961 0.4426095073081419 0.18936961070332334 0.6853895139561521 0.2560548284356062 0.5897176750417177 1.5025005217645866e-07 6.823185368510287 2.8288986623090637 VSGDMQK(ub)QGCDCECLGGGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSGDMQKQGCDCECLGGGR 19 1 Q9NRX4;Q9NRX4-2 Q9NRX4 PHPT1 14 kDa phosphohistidine phosphatase 1 23298400.0 2281800.0 2665600.0 18351000.0 True False 2953835.081002382 2517257.016749283 15011306.29716079 1.0 0.85219958045019 5.081971703060251 21.49415784889272 -6.898801454438845 0.9688014842115236 0.8183116454875943 5.515326195591272 0.985960892284632 0.23223706836430075 0.11229332508319491 0.18243179227420647 0.18018389096274284 0.46605749604115276 1.2624045337060624e-07 6.898801454438845 4.6970145501036775 up VSGEATIGHVEK(ub)FLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSGEATIGHVEKFLR 15 1 Q9BYE7;Q9BYE7-3 Q9BYE7 PCGF6 Polycomb group RING finger protein 6 1 11440400.0 5207400.0 3480400.0 2752600.0 True False 6826951.828533339 2961137.886492942 2467787.3568036472 1.0 0.4337423144128285 0.3614771890566879 22.70281014147751 -13.999999999999998 0.2902613879403391 5.8866212276865655 0.3418365116037872 0.999628047233179 0.005506131225401636 15.981246932749947 0.17085621210950383 46.63929223693901 0.02726048840096813 1.0000000000000041e-14 13.999999999999998 -5.544784716082778 VSGEATIGHVEK(ub)FLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSGEATIGHVEKFLR 15 1 Q9BYE7;Q9BYE7-3 Q9BYE7 PCGF6 Polycomb group RING finger protein 6 1 15876200.0 6497900.0 4420500.0 4957800.0 True False 6291627.721270637 6185628.70260296 3659203.4491881086 1.0 0.9831523695673671 0.5815988502970592 22.585001877622886 -6.9157155407296855 0.8558915371156665 1.0103003429756212 0.5228207431929595 0.9929058201345127 0.016288440773651148 0.10075893218480092 0.11915944177890136 0.013724558348288994 0.03956914751362547 1.214183870398339e-07 6.9157155407296855 -0.48747959978266175 VSGEATIGHVEK(ub)FLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSGEATIGHVEKFLR 15 1 Q9BYE7;Q9BYE7-3 Q9BYE7 PCGF6 Polycomb group RING finger protein 6 1 15024500.0 5207400.0 5517600.0 4299500.0 True False 7132716.504693644 5273814.187736768 3284046.6509820297 1.0 0.7393836814159604 0.4604201847670493 22.7660202030004 -6.970260158540554 0.2519015560799595 1.0864845732569177 0.10512906795483462 0.9999843387156163 0.0008719024702436246 0.07621844100761707 0.008727901896602195 0.0061426091051036864 0.02665372418595096 1.070877617554159e-07 6.970260158540554 -0.981355505302083 down VSGEATIGHVEK(ub)FLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSGEATIGHVEKFLR 15 1 Q9BYE7;Q9BYE7-3 Q9BYE7 PCGF6 Polycomb group RING finger protein 6 1 14312000.0 6497900.0 5322900.0 2491200.0 True False 5403291.755778382 5294224.481187073 3012098.401992624 1.0 0.9798146612248597 0.5574561837737948 22.365407153057163 -6.9168610803937165 0.8476760301815929 1.0104144621365474 0.4940318301952778 0.9932637200958957 0.01674539389815871 0.10005422447326176 0.11544303718405016 0.01419298801734053 0.041318949921613016 1.2109854346181012e-07 6.9168610803937165 -0.5163826319412697 VSGGLEVLAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSGGLEVLAEK 11 0 H0YN26;P39687;O43423 H0YN26 ANP32A;ANP32C Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member C 0 83123000.0 20496000.0 31846000.0 30781000.0 False True 26870454.48354634 27094700.934735708 27596077.392201222 1.0 1.0083454655121924 1.0270044896002488 24.679517387334606 -6.9578109964298065 0.46530180391233794 0.9994839801191823 1.03662482318333 0.9996797918511464 0.00020193352907220576 0.08049309179223962 0.024096617381688182 0.0002557713971701569 0.001540600382079335 1.1020188002564272e-07 6.9578109964298065 0.037140843064147666 VSGGLEVLAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSGGLEVLAEK 11 0 H0YN26;P39687;O43423 H0YN26 ANP32A;ANP32C Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member C 0 52362900.0 20234000.0 8376900.0 23752000.0 False True 19591682.745531645 11721839.854956403 17530638.655273706 1.0 0.5983069452076469 0.8948000477024869 24.223737981386844 -10.255896259759647 5.606884332694982 1.0000170522896588 0.7465534964550604 0.493485293388943 0.12104280222786858 2.5803206146767073e-05 3.424504596811049e-06 0.11720706721412154 0.03906639643389771 5.547582126319031e-11 10.255896259759647 -0.25346355583459834 VSGGLEVLAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSGGLEVLAEK 11 0 H0YN26;P39687;O43423 H0YN26 ANP32A;ANP32C Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member C 0 121457000.0 14724000.0 85206000.0 21527000.0 False True 22337384.4685872 70000323.58248338 17272179.01438071 1.0 3.133774398740551 0.77324088855033 24.412956931719943 -6.6686291617858755 1.9421493574839837 2.3635874119283367 0.7828330708263095 0.2729887040218363 0.9066699284386058 0.4642969227422327 3.374995398377199 0.3759994524217868 1.0064058497131998 2.1447211680060854e-07 6.6686291617858755 -1.5807543411020273 VSGGLEVLAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSGGLEVLAEK 11 0 H0YN26;P39687;O43423 H0YN26 ANP32A;ANP32C Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member C 0 88016000.0 20496000.0 32333000.0 35187000.0 False True 28073925.08357353 30904421.149067223 26876555.299012586 1.0 1.1008229542918406 0.9573493987393468 24.742727448857497 -6.717847196282261 1.76707354474212 1.0614804802419904 0.9575999699718764 0.5023152077123196 0.04243831780587252 0.3595264915549845 2.192821009720837 0.01907793889520636 0.04801425057102048 1.914929562146007e-07 6.717847196282261 -0.10388051027011402 VSGGLEVLAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSGGLEVLAEK 11 0 H0YN26;P39687;O43423 H0YN26 ANP32A;ANP32C Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member C 0 40398600.0 20234000.0 10972000.0 9192600.0 False True 16825467.518185843 10912891.658228524 11114730.158219896 1.0 0.6485936659075476 0.6605896772976154 24.00414325682112 -9.87483203463587 5.349524354702901 1.0000003305364435 0.6545916716062102 0.9990961896695305 0.004897351155556626 1.9309033491036403e-08 4.0616058854879205e-09 0.0047418444182097804 0.0015806132869294698 1.3340372773824904e-10 9.87483203463587 -0.3454086589302333 VSGGLEVLAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSGGLEVLAEK 11 0 H0YN26;P39687;O43423 H0YN26 ANP32A;ANP32C Acidic leucine-rich nuclear phosphoprotein 32 family member A;Acidic leucine-rich nuclear phosphoprotein 32 family member C 0 60872000.0 14724000.0 30061000.0 16087000.0 False True 19060508.253431063 28388078.924257264 13159331.066559095 1.0 1.4893663142034606 0.6903977003965934 24.184083253812393 -6.740960623636351 1.683220025902868 1.2908444193799475 0.6898332289834218 0.6092508888985654 0.20560644355476848 0.3160705794644895 1.758693364254823 0.0966199614129413 0.2368434060159539 1.8156802783712146e-07 6.740960623636351 -0.6010111903965257 VSGILVK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSGILVKR 8 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 3189330.0 921390.0 1328300.0 939640.0 True False 1207951.212753453 1130122.8176728482 842415.066463337 1.0 0.9355699185042419 0.6973916310271355 20.20413075698385 -6.946688495658725 0.594093233994915 1.0027214532394804 0.6181708360955691 0.9989150765790524 0.004286910296906768 0.0848434781637361 0.041681025796652046 0.004425860209502978 0.019978304201029733 1.1306065687171827e-07 6.946688495658725 -0.38455061714391126 VSGILVK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSGILVKR 8 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 6463600.0 1286500.0 1695400.0 3481700.0 True False 1245660.7616944953 2372382.0613941997 2569738.321238909 1.0 1.904516971512376 2.062951969156712 20.24847979333779 -10.881773468327124 0.33256288644983806 1.6641889097964223e-09 2.096598742551009 0.999273736274527 0.012618350002534156 2.6342441896361186 0.16565624432785625 2.1084270085310357 0.05009662437147643 1.312884532118314e-11 10.881773468327124 2.09659874088682 VSGILVK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSGILVKR 8 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 3110490.0 921390.0 910800.0 1278300.0 True False 1262052.7826285048 870557.8443871712 976391.8674148927 1.0 0.6897951150458552 0.7736537495534379 20.267340818506742 -9.957325057240183 6.562075523030838 1.0000000385895222 0.7317244322996426 0.9317219762110618 0.03423514417837022 1.9346391041923312e-08 3.0861758989946895e-09 0.03314804075388371 0.011049345271484158 1.103252557199229e-10 9.957325057240183 -0.2682756062898797 VSGILVK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSGILVKR 8 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 6881600.0 1286500.0 4251100.0 1344000.0 True False 1069781.7516134253 4228198.480522719 1625024.186046119 1.0 3.952393536481462 1.5190240285883427 20.028885068772066 -6.598483549785565 2.1969624354290396 2.9875521503146047 1.5268825254583966 0.016057876898805223 1.276624067998595 0.6450242849212916 5.88181957782956 0.48282051295342804 1.4200574502980967 2.520672655916448e-07 6.598483549785565 -1.460669624856208 VSGILVK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSGILVKR 8 1 Q9UKF6;G5E9W3 Q9UKF6 CPSF3 Cleavage and polyadenylation specificity factor subunit 3 1 4445990.0 1472300.0 952690.0 2021000.0 True False 1905921.373371815 899671.9640181848 1653198.7372111566 1.0 0.472040440171229 0.8674013316123528 20.862057173049294 -9.769159428749557 6.110131868792671 1.0000000099605404 0.669720885891209 0.4819978527711817 0.16140540804919706 2.1930800728980475e-08 4.192431369145909e-09 0.15628011899717587 0.052093371446556215 1.701533763643031e-10 9.769159428749557 -0.33027912406933135 VSGPDLDLNLK(ub)GPSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSGPDLDLNLKGPSLK 16 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 9556400.0 2999300.0 3362800.0 3194300.0 True False 2904088.8632338154 4705583.576770329 2357617.003054096 1.0 1.6203304369724 0.8118267429422935 21.469654168864885 -6.701742307491082 1.8249895358509447 1.3845447349225644 0.8141768644346566 0.4257404557691523 0.2617665933644121 0.39188671788837515 2.5387921131233986 0.11438587667790362 0.29350289077523384 1.9872737342078072e-07 6.701742307491082 -0.5703678704879077 VSGSELVQK(ub)FIGEGAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSGSELVQKFIGEGAR 16 1 P62195;J3QQM1;P62195-2;J3KRP2;J3QSA9 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 18891300.0 4591600.0 6394700.0 7905000.0 True False 6019632.065117653 5440635.686345373 7087066.430114379 1.0 0.9038153208520123 1.1773255164850118 22.521243877895156 -6.81168622914595 1.4075963590707175 0.9476854285253726 1.1822902327818896 0.8641584770575821 0.04175349966067156 0.20450173798246085 0.7982848801788348 0.023323043181097996 0.05390682326268325 1.5428147094679716e-07 6.81168622914595 0.23460480425651697 VSGSELVQK(ub)FIGEGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSGSELVQKFIGEGAR 16 1 P62195;J3QQM1;P62195-2;J3KRP2;J3QSA9 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 30050200.0 6876200.0 11548000.0 11626000.0 True False 6657918.794841591 16159176.622024426 8580801.827476097 1.0 2.4270612363948025 1.2888114276978435 22.666639843678322 -6.589669155141947 2.2294163537000853 1.966034411606475 1.2920508607113808 0.0 0.6184380114393727 0.6705881565858073 6.2826924629172325 0.23157754020893792 0.689644694560076 2.572354652298993e-07 6.589669155141947 -0.6739835508950942 VSGSELVQK(ub)FIGEGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSGSELVQKFIGEGAR 16 1 P62195;J3QQM1;P62195-2;J3KRP2;J3QSA9 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 70041000.0 12759000.0 21191000.0 36091000.0 True False 19356335.80784462 17409300.483961284 28957598.030752752 1.0 0.8994109555025258 1.4960268471379272 24.206302537682802 -6.86352264100234 1.1677260100037814 0.9448197952669116 1.5269349697035506 0.9577848862992937 0.05358311125771517 0.14322160710153775 0.36910502556594094 0.0357331033480962 0.08377579691894185 1.369233004532915e-07 6.86352264100234 0.582115174436639 VSGSELVQK(ub)FIGEGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSGSELVQKFIGEGAR 16 1 P62195;J3QQM1;P62195-2;J3KRP2;J3QSA9 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 19312800.0 4591600.0 6306500.0 8414700.0 True False 6289238.60332437 6027857.977193336 6427321.166186407 1.0 0.9584400207057061 1.021955370366939 22.584453939418047 -6.730131709776166 1.7224969531779966 0.9749938249495183 1.0219204078463737 0.560020397335744 0.017470607691571882 0.33597518726189357 1.952909129456133 0.008037007995263615 0.019942244572871547 1.8615225015953484e-07 6.730131709776166 0.04692658289685547 VSGSELVQK(ub)FIGEGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSGSELVQKFIGEGAR 16 1 P62195;J3QQM1;P62195-2;J3KRP2;J3QSA9 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 25628900.0 6876200.0 10882000.0 7870700.0 True False 5717864.96730995 10823376.506092124 9516426.979994921 1.0 1.8929052308809828 1.6643322349167085 22.447045119112598 -10.18536780710097 4.69142875922937 0.9998828005490102 1.7786187329035068 0.9392898849745943 0.09331453486644233 65503996.76135927 18.321125427625997 83047.03926586725 0.03194404730323226 6.525776458773897e-11 10.18536780710097 0.7787359323544966 VSGSELVQK(ub)FIGEGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSGSELVQKFIGEGAR 16 1 P62195;J3QQM1;P62195-2;J3KRP2;J3QSA9 P62195;P62195-2 PSMC5 26S protease regulatory subunit 8 1 55844000.0 12759000.0 21560000.0 21525000.0 True False 16516777.017490286 20360167.047236823 17607670.865150988 1.0 1.2326961262282958 1.0660476221544621 23.97742885977525 -10.161505220868792 4.07915800820687 0.9999519635031457 1.1493718741517152 0.5171898191372071 0.06803396717502436 47645910.0041314 2.748430653984751 25392.396585683793 0.023289836518257473 6.894373050542291e-11 10.161505220868792 0.1494199106485694 VSGVDGYETEGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSGVDGYETEGIR 13 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 13309800.0 1149900.0 6507600.0 5652300.0 False True 1507530.0356474386 5536691.446426122 5067454.216690127 1.0 3.672690636673306 3.3614283608709714 20.52375531562727 -9.985715882279376 7.766281489655671 0.999999970775866 3.517059498772139 0.9886610019233879 0.12707229198219486 7.344080034615433e-08 9.44285840789504e-09 0.12303721765281701 0.041012405884287166 1.0334372647236222e-10 9.985715882279376 2.517059527996273 VSGVDGYETEGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSGVDGYETEGIR 13 0 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 17693700.0 1149900.0 7739100.0 8804700.0 False True 1575049.104879058 7397160.9722186625 6725211.198488535 1.0 4.696463716149766 4.269842240255067 20.58696537715016 -10.150970383591572 5.046986204447018 0.9998193109694911 4.483152978208122 0.9888739114179815 0.1741674882289961 0.0003541221805144416 5.957347918625796e-05 0.16864493104801642 0.05621231511063397 7.063657227369333e-11 10.150970383591572 3.483333667238631 VSHKPSGLVMAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSHKPSGLVMAR 12 1 Q02750;Q02750-2 Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 0 2902560.0 348800.0 448860.0 2104900.0 False True 337727.5349234674 628092.1387739781 1553563.5443535566 1.0 1.859759936116285 4.600049992090844 18.365500281493556 -6.950081868124072 0.5579435227662152 0.963767490253578 5.626543962553015 0.999207696686386 0.04320976233918329 0.08345287173657284 0.0358263570674093 0.04643428923006024 0.22769195436915696 1.1218069644202279e-07 6.950081868124072 4.662776472299437 VSHLLGINVTDFTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSHLLGINVTDFTR 14 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 348650000.0 98170000.0 163690000.0 86790000.0 False True 128701820.67963222 139268090.05862248 77809803.34846647 1.0 1.0820988337475979 0.6045742238732782 26.939457221879714 -6.862602983646205 1.1725982842504274 1.044885384602014 0.5802831777716497 0.9567217674133411 0.04336855034704222 0.14413952762636612 0.37514395988799265 0.02881581702848885 0.0674703372101256 1.3721355498332298e-07 6.862602983646205 -0.46460220683036435 VSHLLGINVTDFTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSHLLGINVTDFTR 14 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 374889000.0 138630000.0 94519000.0 141740000.0 False True 134229266.53222543 132260929.61007355 104614041.8911459 1.0 0.9853360077648988 0.7793683493460081 27.000124021379044 -6.921248700992474 0.8154169569835477 1.0043432504464314 0.7451816809663309 0.9945206981567527 0.0074561519450200954 0.0974426267444962 0.10184945718794787 0.006467076266520915 0.019609225362953214 1.1988126002793224e-07 6.921248700992474 -0.2591615694801005 VSHLLGINVTDFTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSHLLGINVTDFTR 14 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 327820000.0 77270000.0 114850000.0 135700000.0 False True 117224239.19367947 94354120.17285424 108878835.52057719 1.0 0.8049028155086688 0.9288082078373409 26.80469567483865 -10.411225190914159 5.3933492760614135 1.0000888896966589 0.866855511697956 0.6062354439270592 0.05058416459744 5.4102719077056036e-05 5.90619668799883e-06 0.04901054667905259 0.016325968922307546 3.8794915395165055e-11 10.411225190914159 -0.13323337799870283 VSHLLGINVTDFTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSHLLGINVTDFTR 14 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 530320000.0 98170000.0 145820000.0 286330000.0 False True 134466101.94449705 139377190.2377441 218704751.15145564 1.0 1.0365228724729016 1.626467548242972 27.002667283402605 -6.919544752412967 0.8280780310297511 0.9867695077789133 1.7206183371052373 0.9940541490222365 0.022137980682500648 0.09843964653734691 0.10700078377245938 0.019028513442143038 0.05675528913153702 1.2035253646388265e-07 6.919544752412967 0.733848829326324 VSHLLGINVTDFTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSHLLGINVTDFTR 14 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 311181000.0 138630000.0 79125000.0 93426000.0 False True 115276987.35030647 78698737.9199171 112960944.64698264 1.0 0.6826925280478184 0.9799088893927651 26.78052929681332 -10.517825497834538 8.612205894307047 1.0000118720895719 0.8313007089742249 0.3004821251995985 0.12133807141696426 2.7661198305099675e-05 1.5485794296287467e-06 0.11749334308404276 0.03916169415490241 3.0351104650738e-11 10.517825497834538 -0.16871116311534695 VSHLLGINVTDFTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSHLLGINVTDFTR 14 0 P35579;P35579-2 P35579 MYH9 Myosin-9 0 338270000.0 77270000.0 155950000.0 105050000.0 False True 100027538.21941191 147271245.4089323 85931977.90402389 1.0 1.4723070069553308 0.8590832028229146 26.5758219969311 -6.701023067487189 1.8275232243063841 1.2929970791764367 0.8608911617037511 0.42228061699634734 0.19933048754854693 0.39340676094788557 2.5552192746909665 0.08699738979460479 0.22342713950955892 1.9905676074751188e-07 6.701023067487189 -0.43210591747268556 VSHSHVGYTLSYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSHSHVGYTLSYK 13 0 Q96JZ2;K7EP18;K7ES08 Q96JZ2 HSH2D Hematopoietic SH2 domain-containing protein 0 6350600.0 2081700.0 2082300.0 2186600.0 False True 2729128.8592114747 1771628.956741825 1960351.6073482712 1.0 0.6491554807909292 0.7183067229426001 21.3800090841841 -10.798169348735254 7.134706252435166 1.0114829659229645 0.6837311018667647 0.9653861932091825 0.02823087639187227 0.005160313715247299 0.00014597773369554197 0.027354558739830493 0.00911147617621345 1.5915879824162642e-11 10.798169348735254 -0.3277518640561998 VSHSHVGYTLSYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSHSHVGYTLSYK 13 0 Q96JZ2;K7EP18;K7ES08 Q96JZ2 HSH2D Hematopoietic SH2 domain-containing protein 0 9501900.0 2165100.0 4283800.0 3053000.0 False True 3284614.990012105 3519322.4205178316 2449573.211822563 1.0 1.0714566033521211 0.7457717934282262 21.64729284259539 -6.8492133061959715 1.2389959248464617 1.0381058667054295 0.7329567808195875 0.9391358486365395 0.03448098080399875 0.15832655767136866 0.46812243999536024 0.021781936957879514 0.05037655649379387 1.4150985755593945e-07 6.8492133061959715 -0.305149085885842 VSHSHVGYTLSYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSHSHVGYTLSYK 13 0 Q96JZ2;K7EP18;K7ES08 Q96JZ2 HSH2D Hematopoietic SH2 domain-containing protein 0 10658000.0 2165100.0 4808800.0 3684100.0 False True 2802764.6305014715 4541186.052725067 3013631.6020582044 1.0 1.620252376280543 1.0752353477212977 21.41841916468784 -10.179996908160591 4.834142373217943 0.9999622214265482 1.347743862002111 0.3518266378182049 0.22250227018711605 9.060452557866084e-05 1.5368831768376166e-05 0.2154602630119106 0.07181229891008552 6.606981516485499e-11 10.179996908160591 0.3477816405755627 VSHVLAALQAGNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSHVLAALQAGNR 13 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 35790000.0 8642000.0 12300000.0 14848000.0 False True 11329745.689247042 10464887.945024483 13311671.392073141 1.0 0.9236648581579914 1.1749311729659675 23.433612142582692 -6.82520905922693 1.3492664136045105 0.9590584577064752 1.1810503959443701 0.8959305880123187 0.033930377261408816 0.18679926753620874 0.6667636237503599 0.019754122783682354 0.045477558358422765 1.4955155765011642e-07 6.82520905922693 0.22199193823789487 VSHVLAALQAGNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSHVLAALQAGNR 13 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 21577300.0 5823400.0 2341900.0 13412000.0 False True 5638539.354567995 3277032.8828471643 9898994.84862458 1.0 0.5811847141214533 1.7555955942038477 22.426890054849324 -6.810285137890171 1.4133686928144182 0.7718282950927162 1.7762699623827505 0.8605660257806711 0.18146837245062764 0.206409660795043 0.8126119497588937 0.10095648313576855 0.2334993144611079 1.5478000705166738e-07 6.810285137890171 1.0044416672900343 VSHVLAALQAGNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSHVLAALQAGNR 13 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 23401800.0 5523900.0 10295000.0 7582900.0 False True 8380160.151183717 8457776.81479787 6084136.491296862 1.0 1.0092619546898742 0.7260167325605901 22.99854638450307 -6.899341450961024 0.9654377989338873 1.0119900369320074 0.6966814943691789 0.9862353499272369 0.015415567559776628 0.11189110277935702 0.18017337153066182 0.011990550287291311 0.031095018075378567 1.260835850573574e-07 6.899341450961024 -0.3153085425628285 VSHVLAALQAGNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSHVLAALQAGNR 13 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 29892200.0 8642000.0 6856200.0 14394000.0 False True 11837180.941268656 6553270.413578532 10994433.653735392 1.0 0.553617491030443 0.9288050683930035 23.496822204105584 -10.060626686077166 7.249051456429931 1.0000000401217486 0.7412112797117233 0.38813791237496076 0.1531696870615438 9.939676700637767e-08 1.2956462998228254e-08 0.14830593498749334 0.04943530392776337 8.697076975639586e-11 10.060626686077166 -0.2587887604100253 VSHVLAALQAGNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSHVLAALQAGNR 13 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 15487900.0 5823400.0 5061200.0 4603300.0 False True 4842415.120361929 5033934.311030452 5565828.746745603 1.0 1.0395503454181783 1.1493910803602492 22.2072953302836 -6.9531717611682025 0.522872132284529 0.9981740886410047 1.1956932029863077 0.9994272133845853 0.0015125258527520634 0.08223670129877063 0.030881663498334554 0.001705769319723961 0.009075571420842424 1.1138539231386673e-07 6.9531717611682025 0.197519114345303 VSHVLAALQAGNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSHVLAALQAGNR 13 0 Q9Y490 Q9Y490 TLN1 Talin-1 0 21966000.0 5523900.0 10229000.0 6213100.0 False True 7150797.442347732 9659747.157986334 5082379.551789531 1.0 1.3508629262493652 0.7107430454806585 22.769672706595518 -6.757894568721676 1.6203532058957957 1.204341274162491 0.7086454121096449 0.6822597679373965 0.14753368689212024 0.28650621692085654 1.4820819004881933 0.07185508343736474 0.1730429012402657 1.7462460279935714e-07 6.757894568721676 -0.4956958620528461 VSHVSTGGGASLELLEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSHVSTGGGASLELLEGK 18 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 229968000.0 71919000.0 85792000.0 72257000.0 False True 94286505.46458672 72992168.01459675 64780538.77808653 1.0 0.7741528615885763 0.687060555048544 26.49054796753561 -13.999999997651955 0.13192571181264007 2.0737078309574977 0.5680249663186643 0.9996369855994158 0.002512631156965993 11.934196567528634 0.11313708904129985 3.317147569324197 0.10594329462535773 1.0000000054065742e-14 13.999999997651955 -1.5056828646388334 VSHVSTGGGASLELLEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSHVSTGGGASLELLEGK 18 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 192186000.0 50439000.0 40447000.0 101300000.0 False True 48837841.553912744 56597698.02831856 74766491.06514093 1.0 1.1588902422282445 1.530913092926214 25.5414961043346 -6.9568505348406156 0.4777559114112642 0.990879070133412 1.7143761879476325 0.9996349690501543 0.004250839970091153 0.08084595582308277 0.025438426703449528 0.0052217732187268915 0.030691438049234826 1.1044586608502903e-07 6.9568505348406156 0.7234971178142204 VSHVSTGGGASLELLEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSHVSTGGGASLELLEGK 18 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 387861000.0 57528000.0 270667000.0 59666000.0 False True 87274181.86015253 222364359.11907646 47872988.94746322 1.0 2.547882482306066 0.5485355225005091 26.379051591706173 -6.700047329522084 1.8311919970879382 1.9611521013114466 0.5545699718296848 0.4176110179561545 0.6533764159755822 0.3954054655159739 2.577889426388218 0.2846794213427767 0.7319440676190863 1.995044882627101e-07 6.700047329522084 -1.4065821294817618 VSHVSTGGGASLELLEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSHVSTGGGASLELLEGK 18 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 274328810.0 71919000.0 94654000.0 107755810.0 False True 98509397.83789642 90471873.30107968 82306106.9785687 1.0 0.9184085507248454 0.8355152785931015 26.5537580290585 -6.970928375776003 0.2349664289974294 1.03168601442844 0.7198550584723419 0.9999887361627403 0.00022529684150166554 0.07600269583091518 0.007944616487940032 0.0020540961651559584 0.00815561230077921 1.0692312032232766e-07 6.970928375776003 -0.3118309559560982 VSHVSTGGGASLELLEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSHVSTGGGASLELLEGK 18 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 112987000.0 50439000.0 33004000.0 29544000.0 False True 41942263.326567926 32826200.901218906 35721513.80397801 1.0 0.782652110250461 0.8516830273522831 25.321901379768875 -10.228035357854917 7.415540911440674 1.000000344760775 0.8171675688013721 0.9034110394006956 0.028181753895971506 1.6062690498311712e-07 1.6723701320892647e-08 0.02728691710798604 0.009095621958834474 5.915134744592359e-11 10.228035357854917 -0.18283277595940295 VSHVSTGGGASLELLEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSHVSTGGGASLELLEGK 18 0 P00558;P00558-2;P07205 P00558;P07205 PGK1;PGK2 Phosphoglycerate kinase 1;Phosphoglycerate kinase 2 0 185635000.0 57528000.0 89140000.0 38967000.0 False True 74471130.04641287 84179280.63964239 31875405.835184168 1.0 1.1303612633134354 0.4280236625296053 26.150177913798622 -6.858756324199712 1.1919839281076947 1.0705097896722093 0.39480915711954473 0.9521111246237284 0.06675289197630804 0.14809088034831827 0.4005277180159685 0.04369945584543382 0.10187035170650187 1.3843428941218182e-07 6.858756324199712 -0.6757006325526647 down VSIAVIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSIAVIK 7 0 Q02750 Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 0 13411800.0 4163400.0 3786100.0 5462300.0 False True 5458257.718422949 3221228.6381022097 4897113.594081435 1.0 0.5901569336364932 0.8971935453968185 22.3800090841841 -10.302704111273771 5.771168486145251 1.0000242425612582 0.7436752395166545 0.48166785821439906 0.125347171860975 3.910215001099153e-05 4.724309516023868e-06 0.12137834396142609 0.04045562575931212 4.9807631326624895e-11 10.302704111273771 -0.25634900304460373 VSIAVIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSIAVIK 7 0 Q02750 Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 0 7534200.0 1957400.0 1917500.0 3659300.0 False True 1895263.4084265914 2683167.749630403 2700819.553353111 1.0 1.4157228687583396 1.4250365101467746 20.85396694100372 -11.623699008700275 0.5976254626205045 1.0465952745253588e-12 1.4239083417685408 0.9999556549306281 0.0013198783625636675 5.215284703740719 0.29751550312907293 6.753967647631736 0.0016259370604668937 2.378488145955232e-12 11.623699008700275 1.4239083417674943 VSIAVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSIAVIK 7 0 Q02750 Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 0 14407500.0 4163400.0 2899500.0 7344600.0 False True 5702721.491654469 2771390.5026357058 5609956.746785116 1.0 0.48597682820236626 0.9837332499921122 22.44321914570699 -10.81995087167017 10.392029898715817 1.003567857110103 0.7348550390972393 0.2744847835127098 0.20320820826307331 0.0169007352655314 0.00029281634249262833 0.19796173455816332 0.06558516720129424 1.5137324754383916e-11 10.81995087167017 -0.26871281801286373 VSIAVIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSIAVIK 7 0 Q02750 Q02750 MAP2K1 Dual specificity mitogen-activated protein kinase kinase 1 0 4912700.0 1957400.0 1397500.0 1557800.0 False True 1627664.8275228315 1389971.3901179703 1883528.7775466093 1.0 0.8539665947278529 1.1571969521594818 20.634372216437995 -6.7757487600644355 1.5524110750464768 0.9168555446264132 1.1592873732609956 0.7520669121850955 0.061654159115784535 0.2572367366820158 1.2241481476379334 0.031290314187679434 0.07409940134174198 1.675912113033974e-07 6.7757487600644355 0.24243182863458246 VSIAVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSIAVLR 7 0 P36507;A0A1B0GUL7;G5E9C7 P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 0 13052600.0 3578700.0 3460100.0 6013800.0 False True 4691710.356180096 2943866.5673641604 5391549.6644429965 1.0 0.627461276139178 1.1491650709726882 22.161682520328934 -6.7149621450867825 1.7772358649530082 0.7721463598916047 1.1481433142756894 0.48876382252007977 0.1568696240527647 0.36518583221110007 2.2513338646049696 0.07015829474874158 0.17718953778854143 1.9276929316011832e-07 6.7149621450867825 0.37599695438408465 VSIAVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSIAVLR 7 0 P36507;A0A1B0GUL7;G5E9C7 P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 0 9879600.0 2681000.0 2377300.0 4821300.0 False True 2595893.1225052034 3326568.287455722 3558456.894100338 1.0 1.2814735162306568 1.3708025431594808 21.307799555586552 -13.002381734939265 0.1730769341561635 2.4821868900469165e-08 1.450708313257844 0.9994937837028836 0.0035550790333171815 8.244229646690771 0.12401621022832961 2.8710371735297753 0.07060943870683922 9.945308631171179e-14 13.002381734939265 1.450708288435975 VSIAVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSIAVLR 7 0 P36507;A0A1B0GUL7;G5E9C7 P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 0 14400600.0 3578700.0 5899500.0 4922400.0 False True 4901842.100731097 5638840.582962351 3759830.5000102166 1.0 1.1503513305990278 0.7670239927657906 22.224892581851826 -6.800297046974116 1.4545692923185698 1.0829230343152871 0.7616850744402679 0.8330812218570984 0.06442936979248749 0.2203236691496833 0.9202532438435115 0.034844971356844646 0.08102665152519214 1.5838095342989877e-07 6.800297046974116 -0.32123795987501924 VSIAVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSIAVLR 7 0 P36507;A0A1B0GUL7;G5E9C7 P36507 MAP2K2 Dual specificity mitogen-activated protein kinase kinase 2 0 6630000.0 2681000.0 2503000.0 1446000.0 False True 2229370.288438084 2489515.8421933996 1748351.9144514047 1.0 1.116690150175804 0.7842357653722545 21.08820483102083 -6.81184892595239 1.4065962413774498 1.0634580885768372 0.7781617754903838 0.8646359298239947 0.05066908077853658 0.20428970492623477 0.7962424521499261 0.02832084619950853 0.06546342694793862 1.542236843468737e-07 6.81184892595239 -0.2852963130864534 VSILESLDK(ub)WER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSILESLDKWER 12 1 P10644;P10644-2;K7EPB2;K7EM13 P10644 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 1 99408000.0 23084000.0 41134000.0 35190000.0 True False 30263347.545773983 34996967.53907615 31548876.36631561 1.0 1.1564142891377915 1.0424780774366496 24.85106824266418 -10.098325443032271 5.171192359575029 0.9999978387065266 1.099446183287383 0.5039093751058377 0.04651426364949236 1.1593975913851625e-06 2.022029773436222e-07 0.04503822125577748 0.015012414039549766 7.973969257472361e-11 10.098325443032271 0.09944834458085638 VSILESLDK(ub)WER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSILESLDKWER 12 1 P10644;P10644-2;K7EPB2;K7EM13 P10644 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 1 188456000.0 56863000.0 66568000.0 65025000.0 True False 55057915.19023257 93148949.54753406 47993001.791814305 1.0 1.6918357555982968 0.8716821482613711 25.714446646436016 -6.683046410551753 1.8908119979166589 1.4365191135522435 0.8747041867129194 0.3382570282240691 0.293021251379222 0.43177605886215126 2.987032562359024 0.12422474939177751 0.3263914344521626 2.074691795236508e-07 6.683046410551753 -0.5618149268393241 VSILESLDK(ub)WER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSILESLDKWER 12 1 P10644;P10644-2;K7EPB2;K7EM13 P10644 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 1 220340000.0 64310000.0 108560000.0 47470000.0 True False 97562971.69076648 89186619.8168487 38087533.69315989 1.0 0.914144149888471 0.3903892330574076 26.539830366362015 -6.935484650815397 0.7003096970354339 1.0065812580289444 0.26612601309840267 0.9975106395258422 0.013442627260051127 0.08988826312589743 0.06445059952318212 0.012674581673447875 0.046045932198455965 1.1601532184908933e-07 6.935484650815397 -0.7404552449305417 down VSILESLDK(ub)WER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSILESLDKWER 12 1 P10644;P10644-2;K7EPB2;K7EM13 P10644 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 1 120673000.0 23084000.0 38632000.0 58957000.0 True False 31618778.6216438 36925110.50105973 45032570.85752941 1.0 1.1678221648885458 1.424234990111337 24.91427830418707 -6.964949298490688 0.35892131083124423 0.9776308478845386 1.6231985701643175 0.9999120956024753 0.0016355625707004402 0.07797817101256045 0.014920630125792403 0.003447794221796515 0.021915105978925414 1.0840534639565328e-07 6.964949298490688 0.6455677222797789 VSILESLDK(ub)WER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSILESLDKWER 12 1 P10644;P10644-2;K7EPB2;K7EM13 P10644 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 1 152536000.0 56863000.0 65542000.0 30131000.0 True False 47284103.958021216 65188912.23693154 36431252.789996676 1.0 1.378664430118126 0.7704756935299083 25.494851921870293 -6.738347231351408 1.6928906963624415 1.2257355511878747 0.7702559868420632 0.5974435540039034 0.15910567041349777 0.32081208487252694 1.8046446374297929 0.07437305952543127 0.18282687187972402 1.8266391798128094e-07 6.738347231351408 -0.4554795643458115 VSILESLDK(ub)WER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSILESLDKWER 12 1 P10644;P10644-2;K7EPB2;K7EM13 P10644 PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit;cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed 1 226138000.0 64310000.0 128660000.0 33168000.0 True False 83250562.73961926 121499957.89877056 27131764.332419448 1.0 1.4594490883957505 0.32590487607007296 26.310956688454464 -6.796667713689327 1.469518063188394 1.2545699990907901 0.31151777214953824 0.8222612352956992 0.19626095824957332 0.2255297095796518 0.9618273375867051 0.1050866003233699 0.24490128281752746 1.597100649545853e-07 6.796667713689327 -0.9430522269412519 down VSILESLEK(ub)WER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSILESLEKWER 12 1 P31321;H7BYW5;C9JSK5 P31321 PRKAR1B cAMP-dependent protein kinase type I-beta regulatory subunit 1 37449000.0 10932000.0 26517000.0 0.0 True False 16584643.236253439 21784834.17173337 0.0 1.0 1.313554585492228 0.0 23.98334464185909 -6.879210803738846 1.3416671308985049 1.1637991608635079 3.86516644534492e-18 0.9295458766154406 0.14867723279103678 0.1494723429143762 0.5408776046662588 0.0898803567351403 0.18332548708916938 1.3206544414405718e-07 6.879210803738846 -1.1637991608635079 down VSISEGDDK(ub)IEYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSISEGDDKIEYR 13 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 6826300.0 1634600.0 1691300.0 3500400.0 True False 1582710.5177348037 2366644.9100129865 2583540.2302509346 1.0 1.4953112925540926 1.6323517164392967 20.593965975892523 -11.661303288902555 0.22287060483671256 2.189202596354882e-11 1.713318067771024 0.9993442398535316 0.006955514718387238 4.380571961784044 0.1308190462767175 2.1530868048170295 0.07396847169295134 2.181206137794887e-12 11.661303288902555 1.713318067749132 VSISEGDDK(ub)IEYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSISEGDDKIEYR 13 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 5447400.0 1307700.0 2009300.0 2130400.0 True False 1791192.0292637139 1920522.4821334456 1627243.3969652532 1.0 1.0722035665393699 0.9084695389327668 20.77248858270364 -6.786814098739071 1.508841148336461 1.0405220712837022 0.9068729800216291 0.7909026714842182 0.030636823103948524 0.24013136674755306 1.0799918048492707 0.015984743350482982 0.03751603974989647 1.633751131084108e-07 6.786814098739071 -0.13364909126207314 VSISEGDDK(ub)IEYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSISEGDDKIEYR 13 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 5723900.0 1634600.0 2290300.0 1799000.0 True False 1359242.3250581482 2277961.6993110455 2175162.582363814 1.0 1.6759055080289635 1.600275787667781 20.3743712513268 -10.239099707123646 5.088628833187849 0.9999143112435287 1.6380906478486383 0.9895737133867655 0.03087570404676471 3.0020668600050674e-05 4.488921818446708e-06 0.029899255368953003 0.009965090631144813 5.766340621609412e-11 10.239099707123646 0.6381763366051096 VSISEGDDK(ub)IEYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSISEGDDKIEYR 13 1 P22087;M0R299;M0QXL5;M0R2Q4;M0R0P1;M0R2U2;M0R1H0;M0R2B0 P22087 FBL rRNA 2-O-methyltransferase fibrillarin 1 14290200.0 4742900.0 3881500.0 5665800.0 True False 6139777.546536152 3665491.1128872773 4634682.536017312 1.0 0.5970071529635824 0.7548616380461598 22.54975495483445 -10.242859736533385 5.056564664962125 1.000048095389577 0.6759343955046989 0.8489291455146732 0.06444382367761876 3.494680864396822e-05 5.232625102208046e-06 0.06240670478894758 0.02079915465569226 5.7166323611671155e-11 10.242859736533385 -0.32411369988487804 VSIVNHLEFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSIVNHLEFLR 11 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 6700100.0 2820000.0 2012000.0 1868100.0 False True 3697047.30891885 1711817.4427145747 1674806.9320805385 1.0 0.4630228665413459 0.4530120369409913 21.817942074279117 VSIVNHLEFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSIVNHLEFLR 11 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 5593800.0 1829500.0 2021900.0 1742400.0 False True 1771423.5239176676 2829255.2140692063 1286013.1691204505 1.0 1.5971647524540296 0.7259772447169003 20.756477751943077 -6.722215464594868 1.751273406411423 1.362449925630389 0.7271602440175093 0.5229356891966912 0.2512241787080783 0.35105577582500747 2.105321589539307 0.11384899220297058 0.2850690888777785 1.8957651503053892e-07 6.722215464594868 -0.6352896816128797 VSIVNHLEFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSIVNHLEFLR 11 0 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 0 7720700.0 2820000.0 2130200.0 2770500.0 False True 3862630.207634535 2036080.7203706119 2116164.960238566 1.0 0.5271228698896089 0.5478559547470894 21.881152135802008 -10.199160220115484 4.975778869208751 1.0000478981538485 0.5374894123177574 0.998495154479573 0.008464246451264165 4.497971554878542e-06 7.239193772224769e-07 0.008196317591972164 0.0027318237950202727 6.321785847427947e-11 10.199160220115484 -0.46255848583609116 VSIYASPDK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSIYASPDKR 10 1 Q6P179-3;Q6P179;D6RGW0;Q6P179-2;Q6P179-4 Q6P179-3 ERAP2 Endoplasmic reticulum aminopeptidase 2 1 6118990.0 410590.0 1917700.0 3790700.0 True False 531516.8489388941 1810978.3092062206 3100831.4958665674 1.0 3.407188902518535 5.833928881195363 19.019755899956703 -6.97102464755328 0.23241077993431752 0.042343205645457814 9.268315884274129 0.9999893093726522 0.0064524884708890146 0.07597156257070949 0.007830191521723248 0.061261227308011784 0.23990961654349535 1.06899420877784e-07 6.97102464755328 9.22597267862867 VSK(ub)AAILAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSKAAILAR 9 1 O00767 O00767 SCD Acyl-CoA desaturase 1 7906500.0 1132700.0 2452600.0 4321200.0 True False 1484980.6690824018 2086681.6401599231 3874083.675877323 1.0 1.405191113665691 2.6088445166570375 20.502012720013195 -6.951672477754816 0.54017625131269 0.9822996123255108 3.087337009711549 0.9993260470125526 0.017737301291321842 0.0828211419126028 0.033236932743781415 0.019504292891303846 0.09968223754601103 1.1177058454674417e-07 6.951672477754816 2.105037397386038 up VSK(ub)AAILAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSKAAILAR 9 1 O00767 O00767 SCD Acyl-CoA desaturase 1 35632000.0 1806000.0 12191000.0 21635000.0 True False 2739834.0362855555 10015420.801282262 17358832.76704263 1.0 3.6554844814105443 6.335724185168648 21.38565707481674 -7.024517795753068 0.23894619516222085 1.8795893584044213e-12 9.926122888074527 0.9999898894403454 0.006926386976020881 0.07259967947362676 0.008111394447387161 0.06625094050644288 0.2542487754440714 9.451096646108634e-08 7.024517795753068 9.926122888072648 VSK(ub)AAILAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSKAAILAR 9 1 O00767 O00767 SCD Acyl-CoA desaturase 1 10658900.0 1132700.0 1269100.0 8257100.0 True False 1551489.8000665354 1213026.965647516 6306943.040312532 1.0 0.781846561669626 4.06508830418483 20.565222781536086 -6.891009962917224 1.0163597947885434 0.8278357061443612 4.353160526510032 0.9815378996620187 0.2036721801226929 0.1183286755824468 0.2170776086950476 0.1524801715292959 0.3815548375863606 1.2852571752085848e-07 6.891009962917224 3.525324820365671 up VSK(ub)AAILAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSKAAILAR 9 1 O00767 O00767 SCD Acyl-CoA desaturase 1 32424000.0 1806000.0 11553000.0 19065000.0 True False 2337902.6015822142 10910065.39409681 15595365.623419452 1.0 4.666603898174904 6.670665241941657 21.15678339690919 -8.562167284255992 0.3249982105548537 9.638015181381858e-23 7.531570122000414 0.9983393718811595 0.09568168916868942 0.20564158140562935 0.09598357163060584 0.8130539605127144 0.6018986789664071 2.7405183586524083e-09 8.562167284255992 7.531570122000414 VSK(ub)EEEEKER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSKEEEEKER 10 2 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 17571000.0 3618100.0 8251200.0 5701700.0 True False 4743364.137730244 7020153.122925696 5111742.778568389 1.0 1.4799945606294782 1.077661893572105 22.177479194547963 -10.057893425148091 5.9218884287319185 0.9999992650011982 1.2788282271008125 0.3903872690903726 0.16425162352401326 1.5939639155663364e-06 2.5371535462011404e-07 0.1590363700669625 0.0530119835413253 8.751985205509698e-11 10.057893425148091 0.2788289620996143 VSK(ub)EEEEKER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSKEEEEKER 10 2 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 7057500.0 2092700.0 2775500.0 2189300.0 True False 2026268.383986066 3883771.6240412933 1615856.6524078292 1.0 1.9167113570617704 0.7974544069177664 20.950393844451426 -6.689012916887116 1.8699038195998259 1.5752462486778134 0.801364623507436 0.365841464841522 0.3877815481340674 0.41878041874854127 2.83820750027468 0.1659489182879646 0.43268403069111644 2.046383771799216e-07 6.689012916887116 -0.7738816251703774 VSK(ub)EEEEKER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSKEEEEKER 10 2 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 13163600.0 3618100.0 4962300.0 4583200.0 True False 4955809.345476067 4743049.1778683085 3500742.5539669357 1.0 0.9570685325491834 0.7063916930465868 22.240689256070855 -6.936413156764055 0.6921262497026351 1.0030631018505964 0.6453748854130031 0.9976553551761366 0.0062696629582916314 0.08944175556214494 0.06235060364816726 0.005948386169490215 0.02193777661110846 1.1576755023038954e-07 6.936413156764055 -0.3576882164375933 VSK(ub)EEEEKER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSKEEEEKER 10 2 P23921;E9PL69 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit 1 6829600.0 2092700.0 1901200.0 2835700.0 True False 1740172.7723291242 1890957.8582413478 3428631.759204598 1.0 1.0866494915389386 1.9702823844413828 20.730799119885702 -6.925877615812295 0.7798818266460482 0.9843130229156539 2.1340099854663563 0.9956642813182859 0.028867063153952648 0.09483540479133384 0.08858397621598602 0.025680821657248335 0.08184038257585409 1.1861029448938858e-07 6.925877615812295 1.1496969625507023 VSK(ub)EFIEFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSKEFIEFLK 10 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 5610600.0 1919000.0 1892800.0 1798800.0 True False 2515827.583622433 1610401.6180766139 1612677.4313079985 1.0 0.6401081014295364 0.6410126996803068 21.26260162318834 -10.183646267365274 7.57250142833366 1.0000002364754796 0.6405604005549217 0.9999952485629844 0.0003693006894336098 1.4741682801449914e-09 1.5937319835968632e-10 0.00035757409208161326 0.00011919128499327695 6.551695921031219e-11 10.183646267365274 -0.35943983592055795 VSK(ub)EFIEFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSKEFIEFLK 10 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 10180800.0 3798600.0 3625600.0 2756600.0 True False 3678015.5222485117 5073320.987254227 2034563.7637726327 1.0 1.3793636695020557 0.55316888998033 21.810496137661218 -6.781852361277229 1.5286220137928834 1.2142875175478223 0.546235771258049 0.7739037774250999 0.1605593553330107 0.24770481034147504 1.1433591859518586 0.08271774027525451 0.1948816913702656 1.6525234793019048e-07 6.781852361277229 -0.6680517462897733 VSK(ub)EFIEFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSKEFIEFLK 10 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 25384500.0 4867800.0 8636700.0 11880000.0 True False 7384808.483848745 7095413.406154908 9531912.792811014 1.0 0.9608121079474478 1.2907461058276843 22.816129076233754 -6.87726264874457 1.0950071307645053 0.9764918432687595 1.3129298088933117 0.9714070331864043 0.024885283723226806 0.13007982412526595 0.28720481092880495 0.017548052667808 0.0421539497983443 1.3265919306417702e-07 6.87726264874457 0.3364379656245522 VSK(ub)EFIEFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSKEFIEFLK 10 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 6823100.0 1919000.0 2925200.0 1978900.0 True False 2628506.1590250568 2795954.991657172 1511524.5767248138 1.0 1.0637049420855167 0.5750508027287468 21.32581168471123 -6.8741030628988 1.1121093742442811 1.03710167111126 0.5441028289078685 0.9686119110043787 0.038428055089427746 0.13298426945799066 0.3049148309723101 0.02674341376882064 0.06381035611477134 1.3362783652348682e-07 6.8741030628988 -0.4929988422033914 VSK(ub)EFIEFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSKEFIEFLK 10 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 9460800.0 3798600.0 3651300.0 2010900.0 True False 3158704.2065128316 3631629.7221736936 2431369.892648914 1.0 1.149721368238834 0.7697364911965323 21.590901413095494 -6.7997975333185305 1.4566086408122025 1.0826278881487992 0.7645088510937381 0.8316221384409794 0.06412997082116763 0.2210363577776843 0.92587295871478 0.03463534323246157 0.08056368180588096 1.5856322367931254e-07 6.7997975333185305 -0.31811903705506106 VSK(ub)EFIEFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSKEFIEFLK 10 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 21405500.0 4867800.0 8500800.0 8036900.0 True False 6301463.058683227 8027723.007196237 6574266.665557821 1.0 1.2739458967603208 1.0432921060290403 22.587255398326203 -9.941813978155029 10.73481016959952 0.9999989597550023 1.158619001394647 0.38671461195517876 0.09416401575697014 0.0 0.0 0.09117391620882413 0.03039130540294137 1.143367970010684e-10 9.941813978155029 0.1586200416396446 VSK(ub)YIQEQNEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSKYIQEQNEK 11 1 Q7Z5G4-3;Q7Z5G4 Q7Z5G4-3 GOLGA7 Golgin subfamily A member 7 1 12569640.0 2924480.0 5131000.0 4514160.0 True False 3834021.600704608 4365474.800481346 4047078.0260803443 1.0 1.1386150770979144 1.0555699595788874 21.870427034431863 -10.28337067914567 4.011223074906335 0.9998703938300684 1.097092518346716 0.6457118059599366 0.03390302728602907 18163382.739977635 4.647818755336162 21742.784147889608 0.01240723754634008 5.207500506422313e-11 10.28337067914567 0.09722212451664758 VSK(ub)YIQEQNEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSKYIQEQNEK 11 1 Q7Z5G4-3;Q7Z5G4 Q7Z5G4-3 GOLGA7 Golgin subfamily A member 7 1 7741770.0 2667700.0 2742370.0 2331700.0 True False 2583015.323725155 3837412.642270624 1720957.820499399 1.0 1.485632937220214 0.6662592376794265 21.300624771586403 -6.746141007586731 1.664235303232261 1.2868783445257523 0.6651089520440198 0.6321536726151142 0.20403883498905268 0.3068255345685754 1.6707611122140376 0.09690403200788032 0.23620787151353256 1.7941510037766744e-07 6.746141007586731 -0.6217693924817326 VSK(ub)YIQEQNEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSKYIQEQNEK 11 1 Q7Z5G4-3;Q7Z5G4 Q7Z5G4-3 GOLGA7 Golgin subfamily A member 7 1 9548910.0 2924480.0 3929100.0 2695330.0 True False 4005739.2871003696 3755499.370203813 2058748.5660638188 1.0 0.937529654587756 0.5139497152731782 21.933637095954754 -6.933306614111787 0.7191406327865715 1.0057184695850376 0.4191878379382288 0.9971489673343149 0.011528708275125794 0.09095726795134583 0.06953539292825534 0.010717896166456825 0.03765425874772319 1.1659861342660287e-07 6.933306614111787 -0.5865306316468089 VSK(ub)YIQEQNEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSKYIQEQNEK 11 1 Q7Z5G4-3;Q7Z5G4 Q7Z5G4-3 GOLGA7 Golgin subfamily A member 7 1 7418700.0 2667700.0 2897400.0 1853600.0 True False 2218310.7491481854 2881791.1311111283 2241179.189921937 1.0 1.2990926236180906 1.0103089437683754 21.08103004702068 -10.611145406436608 4.062073509797609 0.9959267921713024 1.1547007836937153 0.2767404522409739 0.11789544361411317 0.004457076338508184 0.0004266669555219234 0.11699026367664572 0.038050590809046145 2.4482434065351387e-11 10.611145406436608 0.1587739915224129 VSLANLK(ub)PNPGSKK(ub)PER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSLANLKPNPGSKKPER 17 3 Q9P015;E5RHF4 Q9P015 MRPL15 39S ribosomal protein L15, mitochondrial 2 5126540.0 1270300.0 881340.0 2974900.0 True False 1665375.6016026982 749847.5074364126 2667085.8852558206 1.0 0.45025729133703296 1.6014921094611403 20.6674161625117 -6.776873080194612 1.5481656698989728 0.6874479975860437 1.609712147782225 0.7560967912427892 0.2321898629239054 0.25548289509164407 1.2092828863346885 0.11815451312210307 0.27951964254931194 1.6715790513023051e-07 6.776873080194612 0.9222641501961812 VSLANLK(ub)PNPGSKK(ub)PER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSLANLKPNPGSKKPER 17 3 Q9P015;E5RHF4 Q9P015 MRPL15 39S ribosomal protein L15, mitochondrial 2 11920900.0 2026700.0 1201600.0 8692600.0 True False 1962363.5178594915 1681405.1462612192 6415747.287589781 1.0 0.8568265415447917 3.2693979628137173 20.904160887555506 -6.89280350914754 1.0056338024339757 0.8789472476921293 3.4886811745613473 0.9826334427714457 0.14563223229261835 0.11689860658907852 0.20878849511335962 0.10991491495939025 0.27693977561595706 1.279960274442541e-07 6.89280350914754 2.609733926869218 up VSLANLK(ub)PNPGSKK(ub)PER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSLANLKPNPGSKKPER 17 3 Q9P015;E5RHF4 Q9P015 MRPL15 39S ribosomal protein L15, mitochondrial 2 5781510.0 1270300.0 902410.0 3608800.0 True False 1739964.2385667176 862538.5423291897 2756475.7655690047 1.0 0.49572199428633046 1.584214034099707 20.73062622403459 -6.780758786870407 1.5331247532004912 0.7147397294894084 1.5930074736496607 0.7699712777560628 0.21331955903324318 0.24941205875305364 1.1580101259003328 0.1095887139524166 0.25839703712468637 1.6566898563216573e-07 6.780758786870407 0.8782677441602522 VSLANLK(ub)PNPGSKK(ub)PER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSLANLKPNPGSKKPER 17 3 Q9P015;E5RHF4 Q9P015 MRPL15 39S ribosomal protein L15, mitochondrial 2 9768100.0 2026700.0 3128200.0 4613200.0 True False 1685290.8480333705 3111347.7657009196 5577798.790973176 1.0 1.8461785212514912 3.3096950579670685 20.684566162989782 -6.9627836258641205 0.3942510551906212 0.9142657359983953 4.294552986411496 0.9998599076873672 0.011292665171769925 0.07872140369144112 0.01756432873608371 0.01885810106172104 0.12289210108945066 1.0894727551030607e-07 6.9627836258641205 3.3802872504131005 VSLANLKPNPGSK(ub)K(ub)PER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSLANLKPNPGSKKPER 17 3 Q9P015;E5RHF4 Q9P015 MRPL15 39S ribosomal protein L15, mitochondrial 2 8376310.0 995510.0 1453500.0 5927300.0 True False 963908.079964624 2033890.1299023677 4374762.314811545 1.0 2.1100457317226895 4.538567946200951 19.87853604941686 -6.958252511316573 0.45939897421320586 0.9287864751243822 5.8176270844664515 0.9996997976051833 0.025602500904951697 0.08033135897822 0.02348315463685297 0.03294852181039136 0.20063367404408045 1.1008990290266385e-07 6.958252511316573 4.888840609342069 VSLANLKPNPGSK(ub)K(ub)PER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSLANLKPNPGSKKPER 17 3 Q9P015;E5RHF4 Q9P015 MRPL15 39S ribosomal protein L15, mitochondrial 2 6566510.0 995510.0 2298800.0 3272200.0 True False 827810.6735706821 2286415.9081239267 3956401.8910566303 1.0 2.7620034159038935 4.779355977606654 19.658941324851135 -6.96935755645702 0.27309318185247317 0.5169370704742314 7.085322281526972 0.9999769298013315 0.007416480843934886 0.07651170344259259 0.00977371897369062 0.03880945531288978 0.1868385522471089 1.073105556272969e-07 6.96935755645702 6.568385211052741 VSLDVNHFAPDELTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSLDVNHFAPDELTVK 16 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 353841400.0 78206000.0 176400000.0 99235400.0 False True 102528823.34798126 150081807.60181445 88967472.74117285 1.0 1.4638011312432513 0.8677313348190743 26.611454302542864 -6.698987788786486 1.8340361389323583 1.2882719971833334 0.8695091298332263 0.41304188714246426 0.19581057030923965 0.39759667047812536 2.599266258168063 0.08518958763040621 0.21939537179474136 1.9999181012558326e-07 6.698987788786486 -0.41876286735010715 VSLDVNHFAPDELTVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSLDVNHFAPDELTVK 16 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 366566500.0 114249300.0 97070400.0 155246800.0 False True 110622518.50840497 135831116.93544862 114583005.77583148 1.0 1.2278794477557327 1.035801817937508 26.72106985202767 -12.917836772321724 9.903933728312163 1.0111127105848305 1.11865440032837 0.0 0.10467971486336995 0.0 0.0 0.0 0.02893432496010393 1.2082678719635218e-13 12.917836772321724 0.1075416897435395 VSLDVNHFAPDELTVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSLDVNHFAPDELTVK 16 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 577716100.0 41046100.0 471486000.0 65184000.0 False True 62269934.57186083 387345639.5630685 52300353.82883789 1.0 6.220427919609638 0.8398973628032669 25.892032427561915 -6.653106106833381 1.9977276775519508 4.379328852360725 0.8627110691408092 0.2065467487849284 2.22647636639959 0.5010313706069995 3.8363047989269488 0.9028328848010552 2.4661348016550813 2.2227667579022429e-07 6.653106106833381 -3.516617783219916 VSLDVNHFAPDELTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSLDVNHFAPDELTVK 16 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 337807200.0 78206000.0 117198000.0 142403200.0 False True 107120871.63768299 112019804.838041 108770497.04596455 1.0 1.0457327608099358 1.0153996637915823 26.674664364065755 -10.389760663401184 4.353093970039866 0.9999325793002509 1.0305662123002448 0.5751741274502074 0.012383435002712025 8.121009256661395e-06 1.138433418878856e-06 0.01201665521726446 0.003996736461126459 4.076048440493007e-11 10.389760663401184 0.030633632999993887 VSLDVNHFAPDELTVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSLDVNHFAPDELTVK 16 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 224284000.0 114249300.0 67904200.0 42130500.0 False True 95003355.05216306 67538386.59667166 50939792.76057733 1.0 0.7109052786566186 0.5361894086014967 26.501475127461948 -9.946071000591752 0.0935825010006863 1.7965692721864404 7.826435842616117e-12 0.9999472543565047 0.0013890327654638888 1.5340684473936326 0.04309073328281077 0.5656906373068873 0.2769520813492243 1.132215248002885e-10 9.946071000591752 -1.796569272178614 VSLDVNHFAPDELTVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSLDVNHFAPDELTVK 16 0 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 0 176112900.0 41046100.0 78905800.0 56161000.0 False True 53134985.589592375 74514622.86622721 45940274.26052242 1.0 1.4023646010138844 0.8645955908477898 25.663158749654364 -6.706448442171436 1.8079593323526024 1.2482580366779685 0.8659913945923203 0.44818992030460614 0.1696514807690454 0.3822526530831531 2.433378747744457 0.07473897553323461 0.19068762254788704 1.965855345776339e-07 6.706448442171436 -0.3822666420856482 VSLDVNHFAPDELTVK(ub)TK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSLDVNHFAPDELTVKTK 18 1 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 1 82598100.0 3521100.0 40429000.0 38648000.0 True False 4616196.19838091 34397150.79100773 34649075.697793886 1.0 7.451405727311206 7.505979860636501 22.138273112288477 -10.183929990017303 0.9953758321696259 2.20865090370156e-15 7.491351584199532 0.9999882888733111 0.010451820905849549 1.5585752559710606 0.586042153991751 4.672157166785576 0.007189187978850346 6.54741712505828e-11 10.183929990017303 7.49135158419953 VSLDVNHFAPDELTVK(ub)TK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSLDVNHFAPDELTVKTK 18 1 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 1 198960000.0 58425100.0 50719900.0 89815000.0 True False 56570427.18078281 70972620.57078435 66289757.10775547 1.0 1.2545887331551566 1.1718093783508559 25.75354472947058 -10.086093318329842 4.424843918928867 0.9999810799763262 1.2131990557169492 0.89841873899505 0.03379453013634395 23677229.968461137 13725147.424908694 5033.779117592173 0.01236753185908172 8.201752915449272e-11 10.086093318329842 0.21321797574062296 VSLDVNHFAPDELTVK(ub)TK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSLDVNHFAPDELTVKTK 18 1 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 1 1109069000.0 107394000.0 242245000.0 759430000.0 True False 162924549.55307364 199014487.0811764 609328327.630007 1.0 1.221513195077739 3.739941766305235 27.279628765356293 -6.924188018329225 0.7930493329476013 0.9523633301789347 4.187937501439037 0.995267386369299 0.08549060952782139 0.0957697384974666 0.09330182738115693 0.07534285983778166 0.2355740700029055 1.1907263973858402e-07 6.924188018329225 3.235574171260102 up VSLDVNHFAPDELTVK(ub)TK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSLDVNHFAPDELTVKTK 18 1 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 1 106402400.0 3521100.0 36127200.0 66754100.0 True False 4822945.824149633 34530980.847325675 50988156.42384447 1.0 7.159728121850524 10.571994437203646 22.20148317381137 -8.451368130787754 0.3782863554605615 3.483878781112774e-20 11.57752152850926 0.9973022435024659 0.20573640058157805 0.16904200280458254 0.11237531307548747 1.012652980604504 0.8845862951699244 3.536974015051814e-09 8.451368130787754 11.57752152850926 VSLDVNHFAPDELTVK(ub)TK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSLDVNHFAPDELTVKTK 18 1 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 1 171453400.0 58425100.0 57123500.0 55904800.0 True False 48583059.32078473 56815764.36737296 67594235.2054099 1.0 1.1694562911781499 1.391312859881836 25.533950004904856 -6.967419149884749 0.3137729615551588 0.9673088144058304 1.6005512303598897 0.9999546784451481 0.001078670356329862 0.07714936565235286 0.01201350320536708 0.0034520029430785987 0.019625951577660086 1.0779059025825543e-07 6.967419149884749 0.6332424159540593 VSLDVNHFAPDELTVK(ub)TK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSLDVNHFAPDELTVKTK 18 1 P04792;F8WE04 P04792 HSPB1 Heat shock protein beta-1 1 1101034000.0 107394000.0 171800000.0 821840000.0 True False 139023650.05222613 162239178.97566265 672273552.790509 1.0 1.1669897813409107 4.835677616995096 27.050755087448742 -6.91641784295285 0.850873588775872 0.908139442525643 5.381140744651498 0.9931265954656204 0.14675266892198244 0.10032547894901465 0.11687563611026375 0.1241001453370005 0.3599083550667018 1.212221987473345e-07 6.91641784295285 4.473001302125855 up VSLDVNHFAPDELTVK(ub)TK(ub)DGVVEITGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSLDVNHFAPDELTVKTKDGVVEITGK 27 2 P04792 P04792 HSPB1 Heat shock protein beta-1 2 97906600.0 7636600.0 20026000.0 70244000.0 True False 11585280.510242682 16452203.836147832 56360242.61096109 1.0 1.4200954238097425 4.864814672474468 23.465789640294865 -6.929639620178635 0.7497456880469142 0.9469096901734193 5.56554803512567 0.9964669129884819 0.10291336044636894 0.09282543443546601 0.07860045206322289 0.09355873392759623 0.3123077997110138 1.1758728956607978e-07 6.929639620178635 4.618638344952251 up VSLDVNHFAPDELTVK(ub)TK(ub)DGVVEITGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSLDVNHFAPDELTVKTKDGVVEITGK 27 2 P04792 P04792 HSPB1 Heat shock protein beta-1 2 85480600.0 7636600.0 15244000.0 62600000.0 True False 9885729.239890778 14395657.999447038 51207442.33024173 1.0 1.456205976323714 5.179935752600836 23.236915962387314 -6.929723818639197 0.7490566743398552 0.9427889220766784 5.939046594705042 0.9964836555730378 0.11101908208028817 0.09278157039252537 0.07838490327624284 0.1009779025797303 0.3374467541158107 1.1756449464351933e-07 6.929723818639197 4.996257672628364 up VSLEDLYNGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSLEDLYNGK 10 0 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 0 12237300.0 4983000.0 1297300.0 5957000.0 False True 4824817.3925562985 1815318.6553301273 4396682.993830643 1.0 0.37624608511211033 0.9112641238223483 22.202042910287524 -10.325742794256936 8.265519780870427 1.0000009520557462 0.6437551044672446 0.3715245433594103 0.21842019967078358 3.832047374651598e-06 3.126400075129155e-07 0.21148501297534583 0.07049481631668694 4.7234269779031305e-11 10.325742794256936 -0.35624584758850164 VSLEDLYNGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSLEDLYNGK 10 0 O60884;A0A087WT48 O60884 DNAJA2 DnaJ homolog subfamily A member 2 0 12049200.0 1433800.0 6700000.0 3915400.0 False True 1963914.606988082 6403971.846062844 2990663.160194214 1.0 3.260819906973535 1.5228071269253323 20.905300770487408 -6.579628940364215 2.267948790322171 2.5398896863677725 1.5270393450177662 0.0 0.9822565831105937 0.7005375983875759 6.776665820068009 0.3637144289163816 1.0983258194100742 2.632516243674118e-07 6.579628940364215 -1.0128503413500063 VSLELHIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSLELHIER 9 0 J3KT10;Q9BW27;Q9BW27-3;J3QL54;F5H0W7;J3QLD4;Q9BW27-2;J3QLH0 J3KT10 NUP85 Nuclear pore complex protein Nup85 0 12503300.0 3384200.0 3303800.0 5815300.0 False True 5134078.81816034 2714211.077292781 4665903.406063459 1.0 0.5286656425476043 0.9088102406139843 22.291674013600616 -9.935362423421676 6.771787160902687 1.0000000173624928 0.7187379415807922 0.4219319188013886 0.155193382289681 4.067920826474974e-08 6.282453784892679e-09 0.15026535521888162 0.050088448754126644 1.1604797767742023e-10 9.935362423421676 -0.2812620757817006 VSLELHIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSLELHIER 9 0 J3KT10;Q9BW27;Q9BW27-3;J3QL54;F5H0W7;J3QLD4;Q9BW27-2;J3QLH0 J3KT10 NUP85 Nuclear pore complex protein Nup85 0 10721100.0 3384200.0 3901100.0 3435800.0 False True 4380913.61255511 3684000.3556574965 2810519.654285054 1.0 0.8409205662261056 0.6415373373787793 22.062800335693066 -6.968070304185698 0.3007276357516841 1.0342820644603616 0.44192185046883437 0.9999631748772607 0.0008899064907881627 0.07693395701999266 0.011259401913635296 0.003295948078748396 0.017868051169305083 1.0762909680702702e-07 6.968070304185698 -0.5923602139915273 VSLFSHLPQYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSLFSHLPQYSR 12 0 A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2;H7C2L8;A0A087WW69;F8W8L6 A0A087WTA5 EIF2B4 Translation initiation factor eIF-2B subunit delta 0 21200400.0 6272600.0 4593800.0 10334000.0 False True 8223439.343944804 3908422.946492148 9264736.810727641 1.0 0.4752783820762358 1.126625542334617 22.971310477425657 -6.692261516783363 1.8580985841536948 0.6717428107536411 1.1244569888610965 0.3811960549348309 0.22181785174328753 0.411805274668818 2.758217522584935 0.09543371095695168 0.24783568172174247 2.0311335657889527e-07 6.692261516783363 0.4527141781074554 VSLFSHLPQYSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSLFSHLPQYSR 12 0 A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2;H7C2L8;A0A087WW69;F8W8L6 A0A087WTA5 EIF2B4 Translation initiation factor eIF-2B subunit delta 0 9446600.0 0.0 1702000.0 7744600.0 False True 0.0 2381617.4758127476 5716056.926980161 0.0 VSLFSHLPQYSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSLFSHLPQYSR 12 0 A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2;H7C2L8;A0A087WW69;F8W8L6 A0A087WTA5 EIF2B4 Translation initiation factor eIF-2B subunit delta 0 11470100.0 6272600.0 5197500.0 0.0 False True 8591749.73064126 4967857.264165919 0.0 1.0 0.5782125201399616 0.0 23.03452053894855 -7.706990271832332 0.6452173678448029 1.0005273228784686 4.818896369898919e-19 0.9875167689863118 0.045798557744775724 0.11994691731116802 0.15143788976107214 0.04283024633418971 0.07786951337384203 1.9634042564689492e-08 7.706990271832332 -1.0005273228784686 down VSLFSHLPQYSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSLFSHLPQYSR 12 0 A0A087WTA5;E7ERK9;Q9UI10-3;Q9UI10;Q9UI10-2;H7C2L8;A0A087WW69;F8W8L6 A0A087WTA5 EIF2B4 Translation initiation factor eIF-2B subunit delta 0 5339400.0 0.0 2893700.0 2445700.0 False True 0.0 2878111.0637455187 2957084.562360854 0.0 VSLGIDICHPDTFSYPIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSLGIDICHPDTFSYPIER 19 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 410220000.0 128190000.0 154570000.0 127460000.0 False True 194473601.94432217 126985775.8390777 102267475.13229743 1.0 0.6529717893302236 0.5258681595334292 27.534999094625515 -13.999999999999998 0.13964250082868365 2.6571776105320057 0.3678912207788595 0.9996043623883115 0.0039857686326268665 11.933640976896685 0.11705347237753827 5.3898874752205765 0.14119560976745196 1.0000000000000041e-14 13.999999999999998 -2.2892863897531464 VSLGIDICHPDTFSYPIER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSLGIDICHPDTFSYPIER 19 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 56098300.0 26474000.0 3954300.0 25670000.0 False True 22014303.99705701 3932997.4010329014 31037478.31533021 1.0 0.17865644998627644 1.4098777921609271 24.391937897045633 -6.726876969571889 1.7343301621086828 0.5040139447662756 1.4087752612884956 0.5448378271001704 0.34536695505910364 0.3421335273427935 2.0145721223718986 0.15789224836506005 0.3932347551810287 1.8755257468106412e-07 6.726876969571889 0.90476131652222 VSLGIDICHPDTFSYPIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSLGIDICHPDTFSYPIER 19 0 Q9H568 Q9H568 ACTL8 Actin-like protein 8 0 293121000.0 128190000.0 95698000.0 69233000.0 False True 165944482.00267136 90372322.1746971 56633304.39056908 1.0 0.5445937164288615 0.3412786234715379 27.306125416717965 -13.07550758964135 0.11925599780214378 2.767340566117502 1.3182974332194737e-20 0.9997268939345563 0.004551366073846131 8.622465416177677 0.09686238030909451 3.8672830759686145 0.283735038816291 8.40412320098155e-14 13.07550758964135 -2.767340566117502 VSLSHACK(ub)NAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSLSHACKNAVK 12 1 Q9NXH9-2;Q9NXH9 Q9NXH9-2 TRMT1 tRNA (guanine(26)-N(2))-dimethyltransferase 1 1931990.0 592420.0 594910.0 744660.0 True False 776668.3570034415 506151.74694101774 667609.7264831082 1.0 0.6516961098992925 0.8595814680269638 19.566939163359606 -10.285804714175386 5.571625837056211 1.0000256332316082 0.755638788963123 0.6481696903646279 0.0848688420681081 2.702595257305415e-05 3.4643308282162797e-06 0.08218251384624756 0.027391300995138163 5.17839632529067e-11 10.285804714175386 -0.24438684426848523 VSLVLAPALAACGCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSLVLAPALAACGCK 15 0 C9JGI3;P19971;P19971-2;A0A494C0L3;A0A494BZZ4 C9JGI3 TYMP Thymidine phosphorylase 0 12507100.0 3083200.0 5226400.0 4197500.0 False True 4042105.05775127 4446641.492347633 3763182.9652631343 1.0 1.1000806334364344 0.9309958329872535 21.946675388401317 -6.74633855438782 1.663337274523756 1.0591071607894949 0.930750613401095 0.6330584217420299 0.042049301668462685 0.30649185344504815 1.667180018124376 0.01997990468778195 0.048694852518137495 1.7933350869063517e-07 6.74633855438782 -0.12835654738839986 VSLVLAPALAACGCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSLVLAPALAACGCK 15 0 C9JGI3;P19971;P19971-2;A0A494C0L3;A0A494BZZ4 C9JGI3 TYMP Thymidine phosphorylase 0 11047500.0 3083200.0 2531300.0 5433000.0 False True 4223142.360347086 2419458.7961102813 4149837.2961473055 1.0 0.5729048631719424 0.9826420570407304 22.00988544992421 -10.693733525104495 9.7679138055277 1.0002265746899717 0.7777734612335265 0.2817180902713199 0.1672745089363931 0.000826183062723193 2.590456071261073e-05 0.16212377190113525 0.053987615612972814 2.024260845948691e-11 10.693733525104495 -0.22245311345644514 VSLVLSALQAGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSLVLSALQAGNK 13 0 Q9Y4G6;H0YMT1;A0A1B0GVU7 Q9Y4G6 TLN2 Talin-2 0 8609300.0 3067300.0 2855900.0 2686100.0 False True 4021260.003775453 2429810.852211007 2408168.138890603 1.0 0.6042411706603708 0.5988590980512671 21.939216189230297 VSLVLSALQAGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSLVLSALQAGNK 13 0 Q9Y4G6;H0YMT1;A0A1B0GVU7 Q9Y4G6 TLN2 Talin-2 0 8346000.0 3598200.0 2211400.0 2536400.0 False True 3483977.1105551017 3094423.552298653 1872040.7496310333 1.0 0.8881871074651287 0.5373286592381662 21.73230371490357 -6.950436065810715 0.5540356301904643 1.0047401915837908 0.4041782503710958 0.9992350605573528 0.005451553914759104 0.08331110963211176 0.03524134549543192 0.005886774851496103 0.029129535187058887 1.1208924249491787e-07 6.950436065810715 -0.600561941212695 VSLVLSALQAGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSLVLSALQAGNK 13 0 Q9Y4G6;H0YMT1;A0A1B0GVU7 Q9Y4G6 TLN2 Talin-2 0 17402200.0 3067300.0 3314900.0 11020000.0 False True 4201363.700665745 3168436.757091606 8417302.964024188 1.0 0.7541448403025756 2.003469245638122 22.00242625075319 -6.855602980397524 1.2077013141039148 0.8678722438529387 2.059094364160497 0.9480750626555314 0.12313924857773556 0.1513993310701975 0.42212586007054054 0.07965359601577064 0.18511517953392853 1.394430969390285e-07 6.855602980397524 1.1912221203075581 up VSLVLSALQAGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSLVLSALQAGNK 13 0 Q9Y4G6;H0YMT1;A0A1B0GVU7 Q9Y4G6 TLN2 Talin-2 0 6858000.0 3598200.0 1573000.0 1686800.0 False True 2992062.7272875486 1564525.936783945 2039502.0811180016 1.0 0.5228920913039361 0.6816374745481724 21.512708990337845 -10.27896604953741 5.101527755962371 1.0000834102332354 0.602264782925944 0.8932762300414854 0.0648075313288743 6.149469825935823e-05 8.691425883648894e-06 0.06276272065966766 0.020916540795407022 5.260583887818989e-11 10.27896604953741 -0.39781862730729145 VSLVLSALQAGNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSLVLSALQAGNK 13 0 Q9Y4G6;H0YMT1;A0A1B0GVU7 Q9Y4G6 TLN2 Talin-2 0 14016100.0 4891800.0 6170000.0 2954300.0 False True 6332531.53179396 5826634.076134098 2416647.7136778445 1.0 0.9201113404457781 0.38162426851639 22.594350924941306 -6.933425331536941 0.718120091120836 1.0072397978991494 0.26077196579826134 0.9971696458498642 0.014610010434454 0.09089791461262799 0.06925057457512983 0.01359278652429492 0.04783930730109205 1.1656674473849212e-07 6.933425331536941 -0.7464678321008881 down VSMLK(ub)MDESTLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSMLKMDESTLLR 13 1 J3KPT4;Q9H4I3;Q9H4I3-2 J3KPT4 TRABD TraB domain-containing protein 1 6510300.0 1191700.0 2182000.0 3136600.0 True False 990951.3512613452 2170245.1329069124 3792448.5580001865 1.0 2.19006223680354 3.8270784465583696 19.91845470741187 -6.966656290712413 0.3283859170591411 0.7967683048137926 5.273833454956988 0.9999433289034397 0.008724582166894994 0.07740331166947273 0.012901892259367493 0.024025950356906176 0.1429714742917357 1.0798009601031671e-07 6.966656290712413 4.477065150143195 VSMPDVDLNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSMPDVDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 17781800.0 7045900.0 2959800.0 7776100.0 False True 6822231.761230662 4141663.5751530943 5739306.132000426 1.0 0.6070833885605169 0.8412651948612652 22.701812335576975 -10.280297833930428 5.675520869682285 1.0000226960394978 0.7241742917108874 0.6490861936556922 0.09560432208003285 2.7458104176077606e-05 3.4818758626337598e-06 0.09257609456947812 0.030856162270116214 5.244476769894277e-11 10.280297833930428 -0.27584840432861035 VSMPDVDLNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSMPDVDLNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 18835700.0 4216400.0 5403300.0 9216000.0 False True 5775317.023925614 5164564.339676324 7039370.609477941 1.0 0.8942477648033689 1.2188717225938743 22.461468711747578 -6.818983482586021 1.3763516123212494 0.9429415105610647 1.2258004793490962 0.8820117667187839 0.04643444116201961 0.1948055118817642 0.7254086275961124 0.026514107328939426 0.061125398802995196 1.5171080661557372e-07 6.818983482586021 0.2828589687880315 VSMPDVELNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSMPDVELNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 27338500.0 6655500.0 10156000.0 10527000.0 False True 8725424.951953681 8640764.387777938 9437767.022114355 1.0 0.9902972560486252 1.0816398140014 23.05679396553434 -6.880631081380463 1.0762443451979815 0.9939343495016078 1.088192813191179 0.9741921358358469 0.00658084124955025 0.12707383662935196 0.2689046643623326 0.004707439911579746 0.01140254152100715 1.3163425463085454e-07 6.880631081380463 0.09425846368957136 VSMPDVELNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSMPDVELNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 24036700.0 6825000.0 5110700.0 12101000.0 False True 6608344.110816115 7151429.161948416 8931385.077781554 1.0 1.0821817148176978 1.3515314771764435 22.655857382298567 -6.949447556743097 0.5648853745033637 0.996563240746492 1.4501308086485976 0.9991571454709842 0.004358847029725287 0.08370852645427762 0.036887705801273055 0.004645338754939303 0.022414756404721025 1.1234466233499017e-07 6.949447556743097 0.4535675679021055 VSMPDVELNLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSMPDVELNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 33609200.0 7613400.0 20585000.0 5410800.0 False True 11550084.414095495 16911445.91866089 4341353.008362112 1.0 1.4641837507284792 0.3758719722484461 23.461400059866023 -6.790803912813894 1.4930110463113537 1.259165055606675 0.36402191728325345 0.803943140960926 0.1974360713862642 0.234158957076694 1.031113097634415 0.10408101494933417 0.24354862930318302 1.618810777759956e-07 6.790803912813894 -0.8951431383234214 down VSMPDVELNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSMPDVELNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 27097000.0 6655500.0 12810000.0 7631500.0 False True 9116218.20812469 12244011.842994789 5829096.875676086 1.0 1.3431021025892624 0.6394205077804076 23.12000402705723 -6.774132197189382 1.5587309032977872 1.195754516920585 0.634838115927329 0.7460790704397587 0.14477529643022374 0.2598006234635139 1.246277961645617 0.07318783679723029 0.17355880027271375 1.6821619409799493e-07 6.774132197189382 -0.560916400993256 VSMPDVELNLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSMPDVELNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 16182400.0 6825000.0 6240800.0 3116600.0 False True 5675289.898765354 6207179.571698183 3768266.6504697376 1.0 1.093720264941627 0.6639778262762427 22.436262657732843 -6.849576241305484 1.23714386926355 1.0499946156167543 0.6469392614283098 0.9396856071621608 0.045312125374119515 0.15792349608842218 0.4653385866303626 0.028663386093555288 0.0663106965922482 1.4139164872821148e-07 6.849576241305484 -0.4030553541884445 VSMPDVELNLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSMPDVELNLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 24334900.0 7613400.0 13096000.0 3625500.0 False True 9855696.382550413 12367196.087690802 2965696.2007714254 1.0 1.2548272194735035 0.30091188746664455 23.232526381958472 -6.83563534656527 1.3025902608550726 1.1357263627673395 0.27216756798531305 0.9166697949207625 0.11641085507928257 0.17396159033539452 0.5752535522676895 0.07012456215809904 0.16140628903115972 1.460039661575501e-07 6.83563534656527 -0.8635587947820265 down VSNFK(ub)PGVYAVSVTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSNFKPGVYAVSVTGR 16 1 D3DTZ5;J3QSB9;P63272 D3DTZ5 SUPT4H1 Transcription elongation factor SPT4 1 5553000.0 1571600.0 1528000.0 2453400.0 True False 1521710.418250347 2138138.3684147326 1810780.93957766 1.0 1.4050888676132944 1.1899642125468817 20.537262409175316 -10.1954944290842 4.480023450658788 0.9999259853995746 1.2975265400852978 0.7183422869538874 0.0878242726852205 6.494208478643597e-05 1.166217396884629e-05 0.08505659036360579 0.028345162122732245 6.375372589965394e-11 10.1954944290842 0.2976005546857232 VSNFKPGVYAVSVTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSNFKPGVYAVSVTGR 16 1 D3DTZ5;J3QSB9;P63272 D3DTZ5 SUPT4H1 Transcription elongation factor SPT4 0 55118000.0 12853000.0 21637000.0 20628000.0 False True 16850407.468629044 18408843.940365434 18493612.437748186 1.0 1.0924865748580728 1.0975172245643525 24.006280142613495 -13.402447454853528 0.420491798623837 1.1542710020960511e-11 1.0976835344962597 0.9998545544464443 0.0005406393913435569 17.813076233785278 0.21571692825637173 16.068868769352683 0.001219566520897983 3.958699581143497e-14 13.402447454853528 1.097683534484717 VSNFKPGVYAVSVTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSNFKPGVYAVSVTGR 16 1 D3DTZ5;J3QSB9;P63272 D3DTZ5 SUPT4H1 Transcription elongation factor SPT4 0 43836800.0 14178000.0 6654800.0 23004000.0 False True 13727927.150644835 9312096.344323542 16978562.294792727 1.0 0.6783322960659891 1.2367899471257904 23.710610466298995 -6.750504633695199 1.647784802928257 0.8109687035941727 1.237954179528219 0.6511739161257026 0.1351713674768468 0.2991884927042346 1.5984289429624394 0.0647948494408338 0.1572329945186194 1.7762143169086654e-07 6.750504633695199 0.42698547593404623 VSNFKPGVYAVSVTGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSNFKPGVYAVSVTGR 16 1 D3DTZ5;J3QSB9;P63272 D3DTZ5 SUPT4H1 Transcription elongation factor SPT4 0 44752900.0 9636900.0 18480000.0 16636000.0 False True 14619881.851760961 15182099.615100974 13347887.308182184 1.0 1.038455698140426 0.9129955661423101 23.801428316639555 -6.824414200264068 1.3525146440187217 1.0206404832620242 0.9099849752528619 0.894267748591578 0.017065173720596235 0.18780595342018727 0.6737987013789994 0.009911460911146345 0.022823696220719676 1.4982552208968008e-07 6.824414200264068 -0.11065550800916224 VSNFKPGVYAVSVTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSNFKPGVYAVSVTGR 16 1 D3DTZ5;J3QSB9;P63272 D3DTZ5 SUPT4H1 Transcription elongation factor SPT4 0 35925000.0 12853000.0 9087000.0 13985000.0 False True 17605101.439264756 8685506.293309432 10682031.030115994 1.0 0.49335167555116144 0.6067577098017624 24.069490204136386 -9.808612181523891 6.365785768457151 1.0000000117230357 0.5500546926763643 0.9545221270195885 0.046297819611657555 7.695506100182343e-09 1.416602681348098e-09 0.04482767208214249 0.014942557026722439 1.5537738874754556e-10 9.808612181523891 -0.44994531904667134 VSNFKPGVYAVSVTGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSNFKPGVYAVSVTGR 16 1 D3DTZ5;J3QSB9;P63272 D3DTZ5 SUPT4H1 Transcription elongation factor SPT4 0 29201500.0 14178000.0 7577600.0 7445900.0 False True 11789635.191896748 7536777.964764174 9002803.264048202 1.0 0.6392715162165792 0.763620172932578 23.49101574173327 -10.375190104414363 4.996002114225924 1.0002256688215203 0.7014458445745307 0.8848727699866968 0.050765126525950166 0.00012769871294064598 1.597022644757776e-05 0.04918994085365915 0.01638437413356939 4.215119539418923e-11 10.375190104414363 -0.29877982424698957 VSNFKPGVYAVSVTGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSNFKPGVYAVSVTGR 16 1 D3DTZ5;J3QSB9;P63272 D3DTZ5 SUPT4H1 Transcription elongation factor SPT4 0 44418900.0 9636900.0 19747000.0 15035000.0 False True 12475157.021698596 18648062.09099193 12298784.27212753 1.0 1.4948158214406861 0.9858620817946986 23.572554638732004 -6.652640909296142 1.9996247611452187 1.320421743107269 0.988022431817793 0.20466576816521953 0.21105799242438028 0.5020621161426835 3.8510614851673286 0.08552328710776962 0.23373569412864828 2.2251489655156938e-07 6.652640909296142 -0.33239931128947586 VSNLQYLHSYLTYIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSNLQYLHSYLTYIK 15 0 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 0 15644200.0 3326800.0 4630200.0 7687200.0 False True 4361467.016777032 3939392.2083782423 6891802.284829253 1.0 0.9032264128617238 1.5801569192931897 22.056382048786205 -6.870656037810825 1.1306858475465822 0.9450505359412218 1.6202873274903333 0.9653302043345154 0.055658510783549324 0.13622392313810477 0.3251056457762289 0.03818892682417797 0.0905138245133934 1.3469267006485225e-07 6.870656037810825 0.6752367915491115 VSNLQYLHSYLTYIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSNLQYLHSYLTYIK 15 0 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 0 38665900.0 13789000.0 6756900.0 18120000.0 False True 13351275.742717002 9454965.406768005 13373828.41165207 1.0 0.7081694355631597 1.0016891770771321 23.670474265282138 -10.970147966792327 10.230100731573883 1.0718109034372727 0.8549293063276969 0.24568396753012645 0.1198289326904742 0.07644739680393972 0.00022307781215634626 0.045193547727880146 0.03867462172533469 1.0711542942258846e-11 10.970147966792327 -0.21688159710957577 VSNLQYLHSYLTYIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSNLQYLHSYLTYIK 15 0 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 0 32879800.0 3326800.0 11014000.0 18539000.0 False True 4556807.863389565 10527365.061572578 14160470.02269003 1.0 2.310249933105987 3.10754160526681 22.119592110309096 -8.604415456553255 0.19949407477698508 2.4538477016444577e-11 4.02440283421997 0.999672309060194 0.01572819317396716 0.21166861842343818 0.05486740413894974 0.5230851120706628 0.3995439799236511 2.48647755592456e-09 8.604415456553255 4.024402834195431 VSNLQYLHSYLTYIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSNLQYLHSYLTYIK 15 0 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 0 31080300.0 13789000.0 4851300.0 12440000.0 False True 11466164.456274811 4825165.083992344 15041146.483938769 1.0 0.4208177113098873 1.3117853438520641 23.450879540716414 -6.7312458218759055 1.7185368114927433 0.6519352474894269 1.3113917337987473 0.5650824780493462 0.24345203825711065 0.3339146624160771 1.9325374583268946 0.11223217664807579 0.2781206119332761 1.8567531874133034e-07 6.7312458218759055 0.6594564863093204 VSNLQYLHSYLTYIKLSTAIKRNENMAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSNLQYLHSYLTYIKLSTAIKRNENMAK 28 3 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 0 25873500.0 4684600.0 5090900.0 16098000.0 False True 4535889.937220394 7123722.918692784 11881450.87035182 1.0 1.5705237598993027 2.619431034438372 22.112954203221427 -6.961657501287604 0.411408076347392 0.9491167206664682 3.279853480204542 0.999826818111072 0.008826004104510276 0.07911426576807366 0.018982170688739187 0.013512278008815144 0.08753641141302547 1.0923014211880262e-07 6.961657501287604 2.3307367595380737 VSNQVAVNMYK(ub)QLGYSVYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSNQVAVNMYKQLGYSVYR 19 1 A8MZB2;P61599 A8MZB2 NAA20 N-alpha-acetyltransferase 20 1 25848600.0 2046500.0 2318100.0 21484000.0 True False 1981534.977697465 3243729.418731804 15856695.893815283 1.0 1.6369781281887859 8.002228611801087 20.918187003047077 -6.926207595947814 0.7772926304594229 0.8883937826689758 9.191131989555203 0.9957389420757334 0.20636980797481042 0.09465526548803235 0.08768203514430539 0.18393255488989665 0.5884110133203739 1.1852020774553237e-07 6.926207595947814 8.302738206886227 up VSNVK(ub)SVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSNVKSVYK 9 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 3335190.0 869430.0 1484500.0 981260.0 True False 1139831.149572096 1263018.3865356771 879728.6281105673 1.0 1.108074987255636 0.7718060946490418 20.120388693962365 -6.820211076779265 1.3709611055901112 1.0582389384260427 0.7644315076026977 0.8848720278906912 0.047560503403242985 0.19320438609866508 0.7134819035095813 0.027261063817256487 0.06282884027062581 1.5128258027356353e-07 6.820211076779265 -0.29380743082334493 VSNVK(ub)SVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSNVKSVYK 9 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 1 2913960.0 869430.0 898230.0 1146300.0 True False 1190881.7664623011 858543.2285506018 875567.5487895567 1.0 0.7209307025507977 0.7352262612858419 20.183598755485257 -10.206259500214674 7.981007972292788 1.0000001257749973 0.7280784819210993 0.9979313953791524 0.005836137414807529 1.306008380383744e-08 1.3029893515256878e-09 0.005650818321615704 0.0018836052511439685 6.21928558545986e-11 10.206259500214674 -0.27192164385389805 VSPEEAIK(ub)CEDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSPEEAIKCEDK 12 1 P05198;H0YJS4;G3V4T5 P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 1 8485100.0 1691100.0 1746300.0 5047700.0 True False 2189162.286564611 1649116.869878928 4129070.393775742 1.0 0.7533095558972192 1.8861417534537255 21.06194747740334 -6.84966074330121 1.2366800670529008 0.8683923512658062 1.931144537462387 0.9398182845753775 0.11932759621662893 0.15782875091050827 0.464659596344369 0.07550926782927608 0.17470045385605115 1.4136414040217368e-07 6.84966074330121 1.062752186196581 VSQCALQK(ub)LILEDCGITATGCQSLASALVSNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSQCALQKLILEDCGITATGCQSLASALVSNR 32 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 180492000.0 26434000.0 51998000.0 102060000.0 True False 40102310.58425935 42718550.63777171 81887796.26551281 1.0 1.0652391349873807 2.0419720228702922 25.257182027385948 -6.920448305587678 0.821396743605065 0.9787955497550637 2.2011138518451374 0.9943045387607696 0.03596502278537959 0.09790860946101736 0.10425314031953263 0.031061355289607104 0.09344578014554752 1.201024023336902e-07 6.920448305587678 1.2223183020900739 up VSQCALQK(ub)LILEDCGITATGCQSLASALVSNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSQCALQKLILEDCGITATGCQSLASALVSNR 32 1 P59047;A0A087WXM3 P59047 NLRP5 NACHT, LRR and PYD domains-containing protein 5 1 79626000.0 26434000.0 15241000.0 37951000.0 True False 34219334.09204002 14392824.95208425 31044307.41014384 1.0 0.4206050565850216 0.9072154159003714 25.028308349478397 -10.172787462907056 7.718947293476067 1.00000013843481 0.6639102362427027 0.38876919229099993 0.19865784731249767 4.7320778091720114e-07 5.087147500432219e-08 0.19234971381204785 0.06411654451955992 6.717575203777179e-11 10.172787462907056 -0.3360899021921073 VSQGQLVVMQPEK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VSQGQLVVMQPEK 13 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 36926290.0 6426890.0 17030400.0 13469000.0 False True 8425715.028091287 14489530.703979263 12075357.083771098 1.0 1.719679653972541 1.4331551735979586 23.006367691667265 -10.243483568238112 5.032079914935025 0.9999100807060141 1.576417413785523 0.843657601448021 0.1169731292901787 0.00011802881560756729 1.7744391970900614e-05 0.11327628927775078 0.037752915141045985 5.708426738983833e-11 10.243483568238112 0.5765073330795089 VSQGQLVVMQPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSQGQLVVMQPEK 13 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 14949400.0 5100700.0 1741400.0 8107300.0 False True 4938781.070482017 2436750.1012810343 5983754.916213398 1.0 0.4933909939529293 1.2115853751803163 22.23572358672845 -6.7171651578554625 1.7694074225024754 0.6908556307600712 1.2102989748036759 0.4991324156754684 0.21326069685040563 0.3608666629050771 2.2064070129676714 0.09575552124784091 0.24119723552682248 1.9179392288260691e-07 6.7171651578554625 0.5194433440436047 VSQGQLVVMQPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VSQGQLVVMQPEK 13 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 38669490.0 6426890.0 11888100.0 20354500.0 False True 8803084.913171731 11362844.433310421 15547186.314086208 1.0 1.290779828365465 1.766106594158092 23.069577753190156 -6.963789476513176 0.37825803054473595 0.9667033630536943 2.1069453189572935 0.9998859683765597 0.0033719852937762356 0.07837424014846206 0.016323687959503085 0.00619746599721637 0.04019854155210857 1.0869523941939468e-07 6.963789476513176 1.1402419559035992 VSQGQLVVMQPEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSQGQLVVMQPEK 13 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 8182000.0 5100700.0 1594400.0 1486900.0 False True 4241458.049323436 1585810.6507363787 1797803.9153511683 1.0 0.3738833750788446 0.42386459902342777 22.016128862162727 -10.181238808362437 8.242365505919869 1.0000001072596967 0.398873989414184 0.9948418014679281 0.02040474923066766 4.022200126878083e-08 3.964681268491188e-09 0.019756817021189907 0.006585604496159578 6.588115305972378e-11 10.181238808362437 -0.6011261178455127 VSQGSK(ub)DPAEGDGAQPEETPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSQGSKDPAEGDGAQPEETPR 21 1 Q14697;F5H6X6 Q14697 GANAB Neutral alpha-glucosidase AB 1 6720580.0 957780.0 1150900.0 4611900.0 True False 1255658.8551547127 979190.2061730629 4134704.828468623 1.0 0.7798218458407754 3.292856822929964 20.260013126843504 -6.8855566825856265 1.0483438424023974 0.8502404285915603 3.491057862812826 0.9778972487347117 0.16893668029449782 0.12282090764566903 0.24351806998217737 0.12344858531725227 0.3032173061613165 1.3014974376335814e-07 6.8855566825856265 2.640817434221266 up VSQGSK(ub)DPAEGDGAQPEETPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSQGSKDPAEGDGAQPEETPR 21 1 Q14697;F5H6X6 Q14697 GANAB Neutral alpha-glucosidase AB 1 12179600.0 1001200.0 1494600.0 9683800.0 True False 969417.4540291725 2091401.5742360353 7147322.272227166 1.0 2.1573797392893845 7.372801307136443 19.88675853240496 -6.942148436513481 0.6392631887380527 0.9429333223920964 8.872827752193926 0.9984319899133124 0.10976348498340899 0.08680001422853253 0.050247729595194524 0.10867358757671146 0.4448053944975656 1.1424877797759427e-07 6.942148436513481 7.92989442980183 VSQGVEDGPDTK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSQGVEDGPDTKR 13 1 Q9UBE0;M0QX65;B3KNJ4;Q9UBE0-2;Q9UBE0-3;A0A590UK93;A0A590UKC5;M0R054;M0QYM8 Q9UBE0 SAE1 SUMO-activating enzyme subunit 1;SUMO-activating enzyme subunit 1, N-terminally processed 1 11893340.0 4680040.0 4679200.0 2534100.0 True False 6135577.761571825 3981081.5993787423 2271895.64080365 1.0 0.648851950718144 0.37028226665676406 22.548767772137875 -7.630107642100088 0.2099302964421579 1.1957685169431445 5.921826115718249e-13 0.9999097251158535 0.002448003035126442 0.1320999915494184 0.024176210119267967 0.04072995752929083 0.07653956230644371 2.3436478582636578e-08 7.630107642100088 -1.1957685169425523 down VSQGVEDGPDTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSQGVEDGPDTKR 13 1 Q9UBE0;M0QX65;B3KNJ4;Q9UBE0-2;Q9UBE0-3;A0A590UK93;A0A590UKC5;M0R054;M0QYM8 Q9UBE0 SAE1 SUMO-activating enzyme subunit 1;SUMO-activating enzyme subunit 1, N-terminally processed 1 17879320.0 7267220.0 5989100.0 4623000.0 True False 7036526.078975107 8380578.862743913 3412097.6129728206 1.0 1.1910108438004356 0.48491223860706617 22.74643191784694 -6.8346691097808865 1.3069496855637883 1.10178094217724 0.46403816104109175 0.9148877282876675 0.08700051147995788 0.17511971241439583 0.583342446431064 0.052239394009366835 0.12022956628333574 1.4632916359675136e-07 6.8346691097808865 -0.6377427811361482 down VSQGVEDGPDTK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSQGVEDGPDTKR 13 1 Q9UBE0;M0QX65;B3KNJ4;Q9UBE0-2;Q9UBE0-3;A0A590UK93;A0A590UKC5;M0R054;M0QYM8 Q9UBE0 SAE1 SUMO-activating enzyme subunit 1;SUMO-activating enzyme subunit 1, N-terminally processed 1 26751030.0 7096770.0 6000460.0 13653800.0 True False 9186908.663250625 5666529.1261717435 11168948.499818752 1.0 0.616804774476417 1.2157461132161531 23.13114805472634 -6.733882067674538 1.7089188118101069 0.770400277005091 1.2156608834960139 0.5772375524803902 0.16104305211747738 0.3290072921607762 1.8840215939184122 0.07462413138546549 0.1843775498321082 1.84551649969839e-07 6.733882067674538 0.4452606064909229 VSQK(ub)SDSSAVLSETNNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSQKSDSSAVLSETNNK 17 1 E9PBC3;Q96MH7 E9PBC3 C5orf34 Uncharacterized protein C5orf34 1 5744000.0 1308900.0 1437400.0 2997700.0 True False 1694396.8522762794 1357407.4264238493 2452149.3589994516 1.0 0.8011154084713311 1.4472107615787857 20.692340383638626 -6.82405130100506 1.3541867665160248 0.8932182145786182 1.4625876184454278 0.8934631421374868 0.08818782768101695 0.18826814131233285 0.6772521780773745 0.05115882685184758 0.11780903435072283 1.4995076957994114e-07 6.82405130100506 0.5693694038668097 VSQMLILTPFQGQGHGAQLLETVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSQMLILTPFQGQGHGAQLLETVHR 25 0 O14929;O14929-2 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 0 9751100.0 1892100.0 2701200.0 5157800.0 False True 2591660.502079892 2581852.0523261135 3939633.8682253994 1.0 0.9962153801603617 1.5201195778010719 21.305445312220787 -6.905273044227946 0.927335402707198 0.9812554550823932 1.5814001153731243 0.9890117459758861 0.02579568300210073 0.10762749772953559 0.15634165723663335 0.020637549731057463 0.05526460161421211 1.2437324219253409e-07 6.905273044227946 0.6001446602907311 VSQMLILTPFQGQGHGAQLLETVHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSQMLILTPFQGQGHGAQLLETVHR 25 0 O14929;O14929-2 O14929 HAT1 Histone acetyltransferase type B catalytic subunit 0 25378600.0 16171000.0 4236600.0 4971000.0 False True 13446902.996766988 4213776.594900738 6010413.1166929025 1.0 0.3133640955031689 0.4469737840853001 23.680770603113114 -9.818515342774923 6.438795581469403 1.0000000153085966 0.38016893980097466 0.9663245420186608 0.05454592695355864 1.198294248409879e-08 2.200067336819496e-09 0.052813868247399184 0.017604622224475362 1.518744286817813e-10 9.818515342774923 -0.619831075507622 VSQQCK(ub)ENMYAVQTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSQQCKENMYAVQTLK 16 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 39761000.0 12325000.0 13950000.0 13486000.0 True False 16158194.355469791 11868714.37667412 12090598.086846607 1.0 0.7345322203440623 0.748264182300404 23.945762653145596 -10.165762466349115 7.764713238512271 1.0000000861026037 0.7413982013247202 0.9978896894988387 0.00560604999339132 8.354343956870408e-09 9.010599673170418e-10 0.005428036385480569 0.001809344855200896 6.827119955297703e-11 10.165762466349115 -0.2586018847778835 VSQQCK(ub)ENMYAVQTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSQQCKENMYAVQTLK 16 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 28856600.0 12311000.0 8436100.0 8109500.0 True False 11920194.043700686 11804678.723680312 5985378.670214816 1.0 0.990309275201655 0.5021209091288101 23.506904385213467 -6.911194248874896 0.8875658504081587 1.0145503411090078 0.4373928499630147 0.9913644231726388 0.02160125298194168 0.10363351322072097 0.13452391568443337 0.017790332039722044 0.049525175410677066 1.2268903515709538e-07 6.911194248874896 -0.5771574911459931 VSQQCK(ub)ENMYAVQTLK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VSQQCKENMYAVQTLK 16 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 179648300.0 29152300.0 76076000.0 74420000.0 True False 44226170.41860876 62499643.41549905 59710854.3805552 1.0 1.413182349363025 1.3501249105536626 25.39839698767626 -10.147366885076329 4.920721563482347 0.9999756724013305 1.381653629959566 0.9799371164520091 0.025743091599178793 6.870981907861839e-06 1.1905625458725878e-06 0.024927227982761705 0.008308547086356073 7.122510775114175e-11 10.147366885076329 0.38167795755823564 VSQQCK(ub)ENMYAVQTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSQQCKENMYAVQTLK 16 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 35063000.0 12325000.0 11860000.0 10878000.0 True False 16881885.57060129 11335985.984224698 8308840.439442371 1.0 0.6714881425310443 0.492174905741079 24.008972714668488 -12.021477474092578 0.09083109660856725 2.237722535191173 1.2837376191236036e-11 0.9998935863892705 0.0021691785027433694 5.708364508878878 0.06727482359181583 1.7324434167797236 0.3649024143826687 9.517492119882497e-13 12.021477474092578 -2.2377225351783356 VSQQCK(ub)ENMYAVQTLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VSQQCKENMYAVQTLK 16 1 Q9Y6I3-3;Q9Y6I3;Q9Y6I3-1 Q9Y6I3-3 EPN1 Epsin-1 1 144377300.0 29152300.0 59287300.0 55937700.0 True False 37738227.02774375 55987909.63727478 45757612.56927101 1.0 1.4835861153761818 1.2125003258799547 25.16952330976871 -10.250004720740378 5.2116605070716915 0.999957055201693 1.3480432206281427 0.687286700723194 0.11067031013114821 5.523012938653209e-05 7.94762397647648e-06 0.10716925917530631 0.03571868900475716 5.6233521262598825e-11 10.250004720740378 0.34808616542644977 VSQTTWDSGFCAVNPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSQTTWDSGFCAVNPK 16 0 H3BNA2;H3BU76;H3BSL1;P31146;H3BRY3;H3BTU6;H3BRJ0 H3BNA2;P31146 CORO1A Coronin;Coronin-1A 0 78360000.0 12435000.0 31768000.0 34157000.0 False True 16302405.420711309 27028338.230694126 30622761.29707995 1.0 1.6579355949739853 1.8784198102554497 23.95858151409723 -10.943401400519939 0.21409459389693838 4.2817828571566733e-17 2.030728585900451 0.9993209932178173 0.00972323983913591 2.9435839520522626 0.11642167333031393 1.587937756931148 0.12476712070811069 1.1391963884814806e-11 10.943401400519939 2.030728585900451 VSQTTWDSGFCAVNPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSQTTWDSGFCAVNPK 16 0 H3BNA2;H3BU76;H3BSL1;P31146;H3BRY3;H3BTU6;H3BRJ0 H3BNA2;P31146 CORO1A Coronin;Coronin-1A 0 54640000.0 12435000.0 22216000.0 19989000.0 False True 17032555.54323952 21234423.66151226 15268009.886377435 1.0 1.2466962815771077 0.8964015909190762 24.02179157562012 -6.71746361840453 1.7683053887755875 1.1504958502024376 0.8970207088535026 0.5004881203305407 0.1038450699756174 0.3603178602540845 2.2004688493077573 0.04665267000127863 0.11747251083942174 1.916621614698517e-07 6.71746361840453 -0.253475141348935 VSREELEDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSREELEDR 9 1 J3QLR9;I3L1B5;I3L2P2;H3BPS4;H3BPF5;H3BS47;A0A087WX34;H3BV03;Q68CZ1-2;Q68CZ1 J3QLR9 RPGRIP1L Protein fantom 0 95808100.0 12753600.0 18086800.0 64967700.0 False True 16720093.106038092 15388319.941794215 58245465.61818367 1.0 0.9203489385018474 3.483561081196947 23.99507954531726 -6.899729356667936 0.9629938892780697 0.8926381756978617 3.7511236828423935 0.9864307005897865 0.1386176259952383 0.11160420954852698 0.1785527785886162 0.10801577749355688 0.2806538686091028 1.2597101925576366e-07 6.899729356667936 2.8584855071445316 up VSREELEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSREELEDR 9 1 J3QLR9;I3L1B5;I3L2P2;H3BPS4;H3BPF5;H3BS47;A0A087WX34;H3BV03;Q68CZ1-2;Q68CZ1 J3QLR9 RPGRIP1L Protein fantom 0 461393100.0 32782800.0 292282100.0 136328200.0 False True 31742127.95839748 408991866.7610155 100619754.66166584 1.0 12.884828241416479 3.1699120737444626 24.91989551236322 -10.361139749291059 9.707120492546188 1.0000002320444756 8.027370155885617 0.41095527154229505 3.966097917452753 0.0003793083912920233 2.4947379470126583e-05 3.840160047215595 1.2800525986433986 4.3537175520173656e-11 10.361139749291059 7.027369923841141 VSREELEDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSREELEDR 9 1 J3QLR9;I3L1B5;I3L2P2;H3BPS4;H3BPF5;H3BS47;A0A087WX34;H3BV03;Q68CZ1-2;Q68CZ1 J3QLR9 RPGRIP1L Protein fantom 0 32753400.0 10775300.0 20028600.0 1949500.0 False True 16346917.879948925 16454339.84583396 1564180.470503797 1.0 1.0065713895838921 0.09568656807301978 23.9625153134839 -6.9168636427732455 0.9414645483507955 1.0316101877600705 5.90148134992056e-20 0.9890249399751065 0.04482288420567972 0.10406533535195713 0.15835298162546904 0.035819301688034134 0.09229800204710868 1.2109782897077628e-07 6.9168636427732455 -1.0316101877600705 down VSREELEDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSREELEDR 9 1 J3QLR9;I3L1B5;I3L2P2;H3BPS4;H3BPF5;H3BS47;A0A087WX34;H3BV03;Q68CZ1-2;Q68CZ1 J3QLR9 RPGRIP1L Protein fantom 0 171054600.0 12753600.0 149834400.0 8466600.0 False True 17468950.573080774 143214220.7718984 6466963.455100469 1.0 8.198215466508216 0.3701975930406433 24.05828960684015 -6.664955540063372 1.9551815730491886 5.614471419803775 0.4024801661762221 0.2568228093294467 3.0612688548602125 0.4728798660468661 3.4799860367605597 1.2626736590168346 3.3959863014390064 2.162939938583708e-07 6.664955540063372 -5.211991253627553 VSREELEDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSREELEDR 9 1 J3QLR9;I3L1B5;I3L2P2;H3BPS4;H3BPF5;H3BS47;A0A087WX34;H3BV03;Q68CZ1-2;Q68CZ1 J3QLR9 RPGRIP1L Protein fantom 0 75525400.0 32782800.0 37137300.0 5605300.0 False True 27260350.724284995 36937233.99372313 6777342.3140210565 1.0 1.354980145608231 0.2486153748558867 24.700300787797495 -6.820355351447147 1.370326307113632 1.19125505554775 0.22427186303158028 0.8852252375702359 0.15625887368094327 0.1930014933468111 0.7120315860918192 0.08960703718258213 0.2065114382894889 1.5123233183628047e-07 6.820355351447147 -0.9669831925161696 down VSREELEDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSREELEDR 9 1 J3QLR9;I3L1B5;I3L2P2;H3BPS4;H3BPF5;H3BS47;A0A087WX34;H3BV03;Q68CZ1-2;Q68CZ1 J3QLR9 RPGRIP1L Protein fantom 0 15586900.0 10775300.0 3545000.0 1266600.0 False True 13948838.26291741 3347717.633694556 1036091.7964134844 1.0 0.23999974554113 0.07427799913401426 23.73364163557635 -12.736182267990813 0.23745263365852576 3.5833166001288648 2.365867381727709e-16 0.9994071127972703 0.009813911864196693 7.639017060315512 0.15086381082253955 9.443462519098068 0.08184745299345413 1.835767732773942e-13 12.736182267990813 -3.5833166001288643 VSRPLELCYAPTK(ub)DPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSRPLELCYAPTKDPK 16 2 Q06587;Q06587-2 Q06587 RING1 E3 ubiquitin-protein ligase RING1 1 14725300.0 3373800.0 5652300.0 5699200.0 True False 4621185.033516805 5402562.696343435 4353166.338708403 1.0 1.1690859935621292 0.9420021719830519 22.13983142589045 -6.707345198032184 1.8044691730663662 1.1042337360807868 0.9425731775412355 0.45245851239907053 0.0712828080802021 0.3804986585569365 2.4133781547892994 0.0314548085327186 0.08017425516586923 1.9618003241995228e-07 6.707345198032184 -0.1616605585395513 VSSAVK(ub)AELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSSAVKAELR 10 1 P30153;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 20155880.0 4026180.0 6521400.0 9608300.0 True False 5278360.969582585 5548432.540218098 8614125.2853217 1.0 1.0511658016933372 1.6319697222228644 22.33165858448617 -6.924210477102161 0.7928660114256149 0.9890233131328623 1.7353460835242085 0.9952730174336974 0.01970570183772589 0.09575713684257617 0.09323514855234048 0.01736881288366408 0.054321208909028446 1.1906648226630442e-07 6.924210477102161 0.7463227703913462 VSSAVK(ub)AELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSSAVKAELR 10 1 P30153;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 43871200.0 5503100.0 9920000.0 28448100.0 True False 5328407.102744638 13881107.73211659 20996689.185293525 1.0 2.6051139607869853 3.940518954431659 22.345272881214157 -7.294185745974486 0.1918581038536893 2.279810556752973e-16 6.153843007694885 0.9999831079064686 0.004940807003182825 0.10974337606375346 0.011910621153642305 0.10394219099972088 0.24645493142160688 5.079421513149668e-08 7.294185745974486 6.153843007694885 VSSAVK(ub)AELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSSAVKAELR 10 1 P30153;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 171233500.0 16903300.0 23056200.0 131274000.0 True False 25643541.896758355 18941640.97108718 105327636.36056188 1.0 0.7386515110645314 4.107374745057216 24.61209220557471 -6.888158969005136 1.0331823672380094 0.8109260761111012 4.386908368653665 0.9796946195393286 0.21804246101380134 0.12065081076901389 0.2306599990661261 0.1611727416445464 0.39924431663294196 1.2937222011331584e-07 6.888158969005136 3.5759822925425637 up VSSAVK(ub)AELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSSAVKAELR 10 1 P30153;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 11078580.0 4026180.0 4349900.0 2702500.0 True False 5514767.549423407 4157707.0348043 2064225.159734603 1.0 0.7539224450609902 0.37430864333537084 22.394868646009062 -6.964787323844718 0.361689662381139 1.032086370843506 0.08310169318352621 0.9999086863496097 0.002459367039388878 0.0780332702092671 0.015115279544225197 0.005076037288044641 0.03239131284659557 1.0844578483807673e-07 6.964787323844718 -0.9489846776599797 down VSSAVK(ub)AELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSSAVKAELR 10 1 P30153;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 40089500.0 5503100.0 15667100.0 18919300.0 True False 4576071.478666024 15582698.222624153 22875238.15704041 1.0 3.405256735012077 4.998881303250271 22.125678156648434 -8.236667129452227 0.25771783924137526 9.030236092653716e-15 6.2679777214143835 0.999382972136642 0.040829753491467544 0.0943029126894541 0.059282297826809015 0.5057914580722133 0.5564967857818043 5.798729771860405e-09 8.236667129452227 6.267977721414375 VSSAVK(ub)AELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSSAVKAELR 10 1 P30153;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 55289800.0 16903300.0 21670500.0 16716000.0 True False 21881655.06385637 20464517.62509953 13673859.520644085 1.0 0.935236277392123 0.6249006065007514 24.38321852766716 -6.940758788282897 0.6524707915947792 1.003443037523573 0.5393125346863148 0.9982615439600571 0.006825759939688794 0.08742231384859568 0.0530469865757956 0.00668317482774452 0.02662196505577597 1.1461493480828522e-07 6.940758788282897 -0.4641305028372582 VSSDNVADLHEK(ub)YSGSTP ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSSDNVADLHEKYSGSTP 18 1 P28074;P28074-3 P28074 PSMB5 Proteasome subunit beta type-5 1 173491400.0 7765400.0 59776000.0 105950000.0 True False 11780679.526783966 49108505.76798034 85008936.06046537 1.0 4.16856308299786 7.215962022156131 23.48991942253499 -7.307875405435758 0.2619975837708531 1.2547166054315888e-16 10.449652547752853 0.9999180636661061 0.022971982559067582 0.11419180913922004 0.018914430354762677 0.15632912993009143 0.49139093942579765 4.9218071695103146e-08 7.307875405435758 10.449652547752853 VSSDNVADLHEK(ub)YSGSTP ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSSDNVADLHEKYSGSTP 18 1 P28074;P28074-3 P28074 PSMB5 Proteasome subunit beta type-5 1 31607600.0 4738600.0 13351000.0 13518000.0 True False 3940355.8555735606 13279075.513033992 16344551.299829904 1.0 3.370019358594474 4.147988633237487 21.90989449542416 -9.45963140447691 0.3378182647130029 1.2864209488848117e-21 4.364800765673348 0.9984718849671906 0.05233613972159392 0.8269948834453779 0.13567384798648807 1.2065964895570611 0.23683993270378184 3.470312587565997e-10 9.45963140447691 4.364800765673348 VSSDNVADLHEK(ub)YSGSTP ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSSDNVADLHEKYSGSTP 18 1 P28074;P28074-3 P28074 PSMB5 Proteasome subunit beta type-5 1 136833400.0 7765400.0 64442000.0 64626000.0 True False 10052463.378918337 60855746.05092927 52864731.11875724 1.0 6.053814250003014 5.258883233499089 23.261045744627438 -9.891031782215922 6.429644777552461 0.9999996553478161 5.65634874175142 0.978608649724469 0.32452922852574717 1.6057349789780628e-06 2.7672999657996076e-07 0.31422409307962323 0.10474135811961899 1.2851926044923336e-10 9.891031782215922 4.656349086403604 VSSGTWVGYQYPGYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSSGTWVGYQYPGYR 15 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 109128000.0 40270000.0 31269000.0 37589000.0 False True 52794359.975234695 26603787.085607387 33699650.859148555 1.0 0.5039134312469543 0.6383191476316168 25.653880478826075 -10.37693064123107 8.807810099907334 1.0000013946427078 0.5711162894393068 0.9313956211098952 0.054870903942609274 1.5027331255409e-06 1.0624297483131504e-07 0.05312869683342281 0.01770950809675605 4.198260267293551e-11 10.37693064123107 -0.42888510520340095 VSSGTWVGYQYPGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSSGTWVGYQYPGYR 15 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 98053000.0 31618000.0 12084000.0 54351000.0 False True 30614303.89681819 16909204.217227526 40114842.604950376 1.0 0.5523301876867086 1.3103300581372879 24.86770254390546 -6.746669249029284 1.6620266476326582 0.7357146410585141 1.3114740152813822 0.6345512036191174 0.18809189867816964 0.3059032308399164 1.6614503166396972 0.08943738536167241 0.21790688407192502 1.7919700670931149e-07 6.746669249029284 0.575759374222868 VSSGTWVGYQYPGYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSSGTWVGYQYPGYR 15 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 74168000.0 19169000.0 36582000.0 18417000.0 False True 29080774.441615622 30053656.28352946 14776871.877542146 1.0 1.0334544681355393 0.5081319930873613 24.793562353971147 -6.891709659121752 1.0121881286342749 1.0270801415422148 0.4614019145229734 0.9819710867507878 0.032244401585739636 0.11776798036565492 0.21382019451047388 0.024216128432689436 0.06075644127697707 1.2831881516164448e-07 6.891709659121752 -0.5656782270192414 VSSGTWVGYQYPGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSSGTWVGYQYPGYR 15 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 106895000.0 40270000.0 33263000.0 33362000.0 False True 55158907.25583067 31793330.673968446 25482582.711957756 1.0 0.5763952234678774 0.46198490832619016 25.717090540348966 -13.999999999999998 0.18371072049335305 3.22363619915817 0.3745015121418842 0.9994941293757733 0.005204963132356864 12.255022729068928 0.13590158258955312 9.736175003905263 0.08280343415119644 1.0000000000000041e-14 13.999999999999998 -2.849134687016286 VSSGTWVGYQYPGYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSSGTWVGYQYPGYR 15 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 76674000.0 31618000.0 27738000.0 17318000.0 False True 26291767.914895702 27588569.888438053 20939113.730615083 1.0 1.0493234984326651 0.7964133031446679 24.648107819339735 -6.8561008094158815 1.2052117150757278 1.0265315021928652 0.785043595656334 0.9487288739036304 0.02478637351674589 0.1508743065193493 0.4186566328617138 0.016063475733359492 0.03734899769554084 1.3928334577713759e-07 6.8561008094158815 -0.24148790653653118 VSSGTWVGYQYPGYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSSGTWVGYQYPGYR 15 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 83097000.0 19169000.0 34372000.0 29556000.0 False True 24814648.377480328 32459167.984583717 24177111.27016969 1.0 1.3080647966803716 0.9743080338027593 24.564688676063597 -6.664154495247705 1.9584096227671588 1.197621040011148 0.9756955169934819 0.25327210242230913 0.13103900741725533 0.4746913034885092 3.504171099353284 0.053980737891579006 0.145314732865821 2.1669331062571074e-07 6.664154495247705 -0.2219255230176661 VSSK(ub)NSLESYAFNMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VSSKNSLESYAFNMK 15 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 194769300.0 56478800.0 78124300.0 60166200.0 True False 74044253.74147715 66468458.96613627 53940778.77894336 1.0 0.8976855813579877 0.7284937865303586 26.141884442664946 -6.963586085454809 0.3815417391539573 1.0114222553416794 0.6087593928728746 0.9998809636993431 0.0012214814636096294 0.07844410791021511 0.0165723103004607 0.0021984989500998166 0.01428608360897386 1.0874615606304834e-07 6.963586085454809 -0.4026628624688048 VSSK(ub)NSLESYAFNMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VSSKNSLESYAFNMK 15 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 292344700.0 75693500.0 86580300.0 130070900.0 True False 73290651.27502719 121152265.30029991 96001429.24664207 1.0 1.6530384597848558 1.3098727815419655 26.127125848664445 -10.055322726724643 4.382100655055581 0.9999670312067251 1.4814556206345955 0.7240984906307115 0.14009680168657876 31922372.15900748 0.8414999631120514 11242.880207436585 0.04986524978200197 8.803944037286716e-11 10.055322726724643 0.4814885894278703 VSSK(ub)NSLESYAFNMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSSKNSLESYAFNMK 15 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 308912700.0 82671700.0 134950000.0 91291000.0 True False 125419013.01084638 110867118.13083737 73247293.8357332 1.0 0.8839737729497955 0.5840206526692943 26.90218083050216 -6.954739520120675 0.5041372082119249 1.0057976409543525 0.4491682200020885 0.9995226317851721 0.0038294040182190138 0.08163662224551141 0.028504613841677455 0.004456717618122404 0.02474756333979452 1.1098402724452843e-07 6.954739520120675 -0.556629420952264 VSSK(ub)NSLESYAFNMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSSKNSLESYAFNMK 15 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 160768100.0 49114700.0 53418000.0 58235400.0 True False 67273731.86486094 51057816.13029631 44481397.91571088 1.0 0.7589562034831209 0.6612000952327848 26.003539954989606 -13.999999999999972 0.1242471698931198 2.146203931053519 0.5137441255594135 0.9996723812294225 0.0025770718786665863 11.949464599001224 0.10900547785694802 3.36439245518134 0.13092301395439324 1.0000000000000655e-14 13.999999999999972 -1.6324598054941055 VSSK(ub)NSLESYAFNMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSSKNSLESYAFNMK 15 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 204255100.0 65396500.0 92190000.0 46668600.0 True False 54380087.30616985 91693354.17171778 56426788.48877369 1.0 1.6861568032332754 1.0376369602181867 25.696575131794827 -10.28187656954125 3.9340388000272535 0.9994601213501707 1.361896881748037 0.29338825818633596 0.26475711740013347 189095645.7327216 153480794.0465009 1050639.0162727507 0.09689118318162754 5.225446798680082e-11 10.28187656954125 0.3624367603978663 VSSK(ub)NSLESYAFNMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSSKNSLESYAFNMK 15 1 A8K7Q2;E9PS65;E9PM13;P11142;E9PKE3;E9PNE6 A8K7Q2;E9PM13;P11142 HSPA8 Heat shock cognate 71 kDa protein 1 228162900.0 82671700.0 98056000.0 47435200.0 True False 107020145.3528374 92599097.40184861 38802480.32625372 1.0 0.8652492210373695 0.36257174009925747 26.67330715259461 -6.946479166982428 0.5962466412007705 1.0057119260652898 0.19654215067591882 0.9988952149117787 0.009117217454342757 0.08493111142742518 0.04205641741536349 0.009392348645098124 0.04219288062660042 1.1311516491457984e-07 6.946479166982428 -0.809169775389371 down VSSSK(ub)QSCLVTFEDNSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSSSKQSCLVTFEDNSK 17 1 A0A087X169;Q5T6S3;X6RER8;B0QZ72;Q5T6S3-3;Q5T6S3-2 A0A087X169 PHF19 PHD finger protein 19 1 6229200.0 1012600.0 2321500.0 2895100.0 True False 1386985.5844860733 2218928.4538261048 2211337.006456117 1.0 1.599820847920561 1.5943475052593967 20.4035213625383 -10.248808939630702 4.927364211908018 0.9998812472665877 1.5970841765905641 0.999936981081424 0.0022344827865678563 2.915563421610986e-06 4.4448566849805335e-07 0.0021639549232642065 0.0007211762180247052 5.638856730459606e-11 10.248808939630702 0.5972029293239765 VSSSK(ub)QSCLVTFEDNSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSSSKQSCLVTFEDNSK 17 1 A0A087X169;Q5T6S3;X6RER8;B0QZ72;Q5T6S3-3;Q5T6S3-2 A0A087X169 PHF19 PHD finger protein 19 1 27295400.0 2748100.0 3904300.0 20643000.0 True False 3557469.6231495533 3687022.2728444673 16886185.815066766 1.0 1.0364170782659323 4.7466844706650875 21.76242000711076 -6.909046020465608 0.9021904493272244 0.8816277154343252 5.21654335942682 0.9905569406680598 0.17080358517369484 0.10505269813040055 0.14220794666416622 0.13918286832725052 0.38172296735286276 1.2329741729180928e-07 6.909046020465608 4.3349156439924945 up VSSVFK(ub)DEATVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSSVFKDEATVR 12 1 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 1 3720650.0 1194200.0 1575000.0 951450.0 True False 1565607.7646492515 1340016.1393019166 853003.0809528555 1.0 0.8559079544435736 0.5448383051063602 20.578291385481492 -6.958523120617818 0.4557711887773824 1.0094602973194926 0.37883467938594045 0.9997114398448127 0.003226537490835582 0.08023296822933298 0.023112962350912227 0.004195172274013711 0.02571024318187559 1.1002132714736998e-07 6.958523120617818 -0.6306256179335521 VSSVFK(ub)DEATVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSSVFKDEATVR 12 1 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 1 5262700.0 1202400.0 1823600.0 2236700.0 True False 1164230.470160484 2551772.9899483696 1650841.1704383115 1.0 2.1918108616386056 1.4179676728532542 20.150945250632994 -10.137772253088912 4.759562675501431 0.9999508906825099 1.8048892672481214 0.5905774379749714 0.31592015903802106 0.0002124619378904938 3.848906692900647e-05 0.3059123131722634 0.10196279287117163 7.281615571886269e-11 10.137772253088912 0.8049383765656115 VSSVFK(ub)DEATVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSSVFKDEATVR 12 1 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 1 15221000.0 2878400.0 3356000.0 8986600.0 True False 4366743.239227216 2757095.5794523177 7210394.571033292 1.0 0.6313848624496278 1.651206442884267 22.058126273700005 -6.808924183431976 1.4190445225865995 0.7988525698343751 1.6686136031232535 0.8570054655599492 0.15943958274497957 0.20826880702055472 0.8267784843982888 0.0883520934320213 0.20447858359076285 1.552658040178905e-07 6.808924183431976 0.8697610332888783 VSSVFK(ub)DEATVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSSVFKDEATVR 12 1 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 1 4413300.0 1202400.0 1858600.0 1352300.0 True False 999848.875351717 1848587.352896784 1635059.677671255 1.0 1.848866762235949 1.63530681283818 19.93135052606727 -10.133939734989797 4.4402290202545265 0.9998955974021451 1.7420867874656516 0.9415182665915456 0.08718548435899899 13224715.389621967 15091407.67216478 11133.0121012629 0.02984591038761648 7.346158002769152e-11 10.133939734989797 0.7421911900635065 VSSVFK(ub)DEATVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSSVFKDEATVR 12 1 P46060 P46060 RANGAP1 Ran GTPase-activating protein 1 1 14499800.0 2878400.0 2722300.0 8899100.0 True False 3726145.5417465405 2570801.611905978 7279555.112476906 1.0 0.6899359091327864 1.9536421835698856 21.829252595792454 -6.841819729540274 1.2739178875321422 0.8350743667618766 1.996726479493514 0.9275397820314722 0.14475252900272367 0.16668226068225622 0.5246664882855285 0.0890713559956597 0.20531407672343197 1.4393959303538105e-07 6.841819729540274 1.1616521127316375 VSSYPVALIPGQFQEYYK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSSYPVALIPGQFQEYYKR 19 1 Q8WUB8-3;Q8WUB8-2;Q8WUB8;S5FZ81 Q8WUB8-3 PHF10 PHD finger protein 10 1 5822600.0 1755700.0 2611000.0 1455900.0 True False 2301739.7022229857 2221448.9775982844 1305257.4339789404 1.0 0.9651173742421189 0.567074301546062 21.13429326137593 -6.92413358745412 0.7934717254697814 1.007544656587588 0.49636025924795535 0.9952540990989166 0.013528594323005495 0.09580048550228051 0.09345711658870573 0.011919116685048064 0.037245097548287184 1.1908756425275772e-07 6.92413358745412 -0.5111843973396327 VSSYPVALIPGQFQEYYK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSSYPVALIPGQFQEYYKR 19 1 Q8WUB8-3;Q8WUB8-2;Q8WUB8;S5FZ81 Q8WUB8-3 PHF10 PHD finger protein 10 1 14725200.0 5132300.0 4856600.0 4736300.0 True False 4969377.945778981 6795865.706834421 3495720.944045675 1.0 1.3675485706630282 0.7034524204412669 22.244633839480592 -6.756445980573172 1.6256564130979896 1.2144294274107201 0.7014260933224895 0.6763852346557143 0.1545237715559636 0.28892007066025616 1.5039852919608692 0.07502544485691742 0.18095013759502462 1.7520803519908425e-07 6.756445980573172 -0.5130033340882306 VSSYPVALIPGQFQEYYK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSSYPVALIPGQFQEYYKR 19 1 Q8WUB8-3;Q8WUB8-2;Q8WUB8;S5FZ81 Q8WUB8-3 PHF10 PHD finger protein 10 1 14489600.0 5132300.0 4449800.0 4907500.0 True False 4267734.849440795 4425828.044183852 5933635.560283727 1.0 1.037043818400239 1.3903477534601794 22.02503911491487 -6.926978748109619 0.7711741329601743 0.9939831585575137 1.457600523698792 0.9959107938297169 0.011250277805628232 0.09423659638738853 0.08558546575654945 0.0100711250319293 0.032514956251321704 1.183099448435448e-07 6.926978748109619 0.46361736514127816 VSTAVLSITAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSTAVLSITAK 11 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 41399000.0 14901000.0 12512000.0 13986000.0 False True 19535355.301489253 10645258.371394012 12538862.883185288 1.0 0.5449226905324054 0.6418548672226814 24.219584159151353 -9.951594391752012 5.853339711074229 1.0000002968282145 0.5933887788773865 0.9591199508722703 0.03957239542537253 1.5327143582307686e-07 2.7507054566149202e-08 0.03831583451770681 0.012771935704242053 1.117906826672808e-10 9.951594391752012 -0.40661151795082795 VSTAVLSITAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSTAVLSITAK 11 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 31898100.0 10959000.0 6921100.0 14018000.0 False True 10611112.54365332 9684731.323059687 10346265.269014282 1.0 0.9126970695313456 0.9750405743460474 23.339072590687167 -10.158608812614737 4.878074747721692 1.00000441402681 0.9438688219385005 0.5194266825069127 0.025451629262804205 1.2218940505278298e-06 2.107762405173186e-07 0.02464537177085915 0.00821447802229409 6.940506853169952e-11 10.158608812614737 -0.05613559208830954 VSTAVLSITAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSTAVLSITAK 11 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 75345000.0 17816000.0 29680000.0 27849000.0 False True 27028174.524066176 24383372.10910157 22344632.943349663 1.0 0.9021464652520411 0.8267163186864049 24.687960740123675 -6.974026747335802 0.12992089452478792 1.116973127779877 0.6099375357900795 0.9999992160310323 6.254573705454555e-05 0.07501640603249331 0.003900123848684745 0.004749977265790389 0.010309401306162487 1.0616301714885306e-07 6.974026747335802 -0.5070355919897974 VSTAVLSITAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSTAVLSITAK 11 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 54065000.0 14901000.0 17237000.0 21927000.0 False True 20410302.38438373 16475412.344863474 16748294.20074031 1.0 0.8072105956386562 0.8205804051955014 24.282794220674244 -10.084382630329952 6.894332027194715 1.0000000905991446 0.8138955004170795 0.996144145554302 0.005458201895409785 7.60225442730404e-09 1.0108968301417242e-09 0.005284883780307493 0.0017616270867632712 8.234123370460081e-11 10.084382630329952 -0.18610459018206515 VSTAVLSITAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSTAVLSITAK 11 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 22550000.0 10959000.0 5835800.0 5755200.0 False True 9112894.066017525 5804361.387084389 6958585.71096176 1.0 0.6369394118965089 0.7635977835966186 23.119477866121443 -10.368020190908306 5.187451506917913 1.0001578947290994 0.7002685977465455 0.8818918401673524 0.051708063719569965 9.447326474638538e-05 1.1509518747537589e-05 0.050092311512399616 0.016688705804201367 4.285285970893986e-11 10.368020190908306 -0.29988929698255395 VSTAVLSITAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSTAVLSITAK 11 0 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 75974000.0 17816000.0 34018000.0 24140000.0 False True 23063163.205863114 32124868.395774696 19746767.697316855 1.0 1.3929081674107877 0.8562037878783616 24.459087062216124 -6.7104802237790375 1.7934413954932886 1.2414384553713225 0.8574463683442611 0.46732478705453606 0.1655579671304425 0.3741537724030441 2.3461878451936657 0.07345251370474447 0.18649891157253512 1.947689738763655e-07 6.7104802237790375 -0.38399208702706134 VSTAVLSITAK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSTAVLSITAKAK 13 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 61801900.0 4590300.0 19528300.0 37683300.0 True False 4444583.43910319 27326052.02873919 27812913.255232252 1.0 6.148169429856161 6.25770978007429 22.083616780617323 -10.13275458896653 0.8286055537104458 2.934631672546229e-18 6.233382437613114 0.9999394451794872 0.019089257871255056 1.440147769435094 0.44369022847772976 3.634889622664823 0.01551150969761513 7.366232308080055e-11 10.13275458896653 6.233382437613114 VSTAVLSITAK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSTAVLSITAKAK 13 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 34344200.0 8788400.0 20130900.0 5424900.0 True False 13332645.318101883 16538383.611560402 4352666.137181866 1.0 1.240442779131464 0.3264668063487898 23.668459716857413 -6.836778542783648 1.2972410382108903 1.1280111468997227 0.2982664369614313 0.9187784857837045 0.11024724294620042 0.17259400675081826 0.5655779324379545 0.0666729387037522 0.1534970096882813 1.4562014434803188e-07 6.836778542783648 -0.8297447099382914 down VSTAVLSITAK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSTAVLSITAKAK 13 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 31777700.0 4257600.0 6639700.0 20880400.0 True False 5831749.777313754 6346336.099448284 15948879.565336699 1.0 1.0882387519670915 2.7348360568177776 22.47549738865071 -6.917978410556185 0.8395805614549189 0.9609546473779326 2.9884013236984006 0.9936007468184739 0.06382228867111316 0.09937601554299784 0.11188458626344248 0.05440869322916675 0.15995994147429973 1.2078738788747044e-07 6.917978410556185 2.027446676320468 up VSTAVLSITAK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSTAVLSITAKAK 13 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 43701700.0 4590300.0 17955200.0 21156200.0 True False 3817037.83476962 17858471.77377183 25579863.604783397 1.0 4.678620581409482 6.701495953688205 21.8640220560516 -8.551480458171971 0.3246997144239796 9.356410438078988e-23 7.576173715626703 0.9983467137562728 0.0959637885438245 0.20065367499546655 0.09539627051954855 0.8081898426326551 0.6073168410579718 2.8087917563460328e-09 8.551480458171971 7.576173715626703 VSTAVLSITAK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSTAVLSITAKAK 13 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 1 37020800.0 8788400.0 22682900.0 5549500.0 True False 11376757.045263097 21420576.67512842 4539547.942678536 1.0 1.8828367864326712 0.3990195030638061 23.439586038949862 -6.745542199112652 1.6663976515372896 1.5218928463823092 0.3970587019546981 0.629522497419295 0.3709213786650218 0.30789834538008876 1.6807517656886617 0.17594571735954506 0.42915783905533417 1.7966264987990908e-07 6.745542199112652 -1.124834144427611 VSTEVDAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSTEVDAR 8 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 18749700.0 1267600.0 9239000.0 8243100.0 False True 1661835.8754558635 7860577.21333994 7390183.085398592 1.0 4.730056276576458 4.44699936651167 20.664346476487832 -10.158202227218183 3.9897643474586206 0.998430785681827 4.588527822438414 0.9953553357210069 0.11555750323792467 7749922.920551535 13903865.655667203 153699.43866372693 0.04228971648015437 6.947007580655682e-11 10.158202227218183 3.590097036756587 VSTEVDAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSTEVDAR 8 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 10353300.0 3547400.0 1650500.0 5155400.0 False True 3434789.728748589 2309553.2572437976 3805046.0813151794 1.0 0.6724001873865061 1.1077959298258084 21.711790352042385 -6.705389983800765 1.8115392621028936 0.7976571058540687 1.1066442832832768 0.44321131200929675 0.13815267877627238 0.38442854010841043 2.4561958832175335 0.06075519641221326 0.1552214594467171 1.9706523529178893e-07 6.705389983800765 0.3089871774292081 VSTEVDAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSTEVDAR 8 0 P37837;F2Z393 P37837 TALDO1 Transaldolase 0 14523400.0 1267600.0 6428800.0 6827000.0 False True 1736265.975601964 6144754.358801321 5214603.2064785035 1.0 3.5390628193764684 3.003343542840894 20.727556538010724 -10.111632343154692 5.169597063355297 0.9999419566216425 3.2712031811119058 0.9599438091528053 0.2187064788254293 0.00014631319501491507 2.514342673920052e-05 0.21176694213236905 0.07058721251492919 7.733349834319235e-11 10.111632343154692 2.2712612244902632 VSTHK(ub)GAELPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSTHKGAELPR 11 1 O95905-2;O95905;O95905-3 O95905-2 ECD Protein SGT1 1 2202620.0 587940.0 463080.0 1151600.0 True False 569276.1665220845 647990.2589302977 849961.4127405371 1.0 1.1382704863425186 1.4930563805845958 19.118769175149254 -6.954901977597974 0.502156717625389 0.993025646503853 1.6536596014354317 0.9995319220234435 0.00449269846610155 0.08157509072189843 0.028263330174442835 0.0052476502267763785 0.02926896827547572 1.1094251897315273e-07 6.954901977597974 0.6606339549315786 VSTVFWK(ub)SGNALFHASTLHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSTVFWKSGNALFHASTLHR 20 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 1 18177600.0 7882300.0 5441000.0 4854300.0 True False 10203792.733361848 5138203.566976607 3970867.209324156 1.0 0.5035582063693802 0.3891560043493624 23.2826021635225 -13.999999999999998 0.20621391693804433 3.8273643377375857 0.31924706911391276 0.9994882381211297 0.005997939206596889 12.660723104114759 0.14395819531037068 14.477630905745164 0.06960953601377708 1.0000000000000041e-14 13.999999999999998 -3.508117268623673 VSVADHSLHLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSVADHSLHLSK 12 0 Q13162;A6NG45 Q13162 PRDX4 Peroxiredoxin-4 0 15889200.0 3633900.0 7353200.0 4902100.0 False True 4764078.090737653 6256131.222549107 4394877.7162635885 1.0 1.3131882188733035 0.9225032907852905 22.183765630762263 -6.693291155481636 1.8550851551360161 1.1957430419336705 0.9238104621235084 0.3857475626144996 0.13236959112569 0.4096105894906042 2.7355622612365966 0.057034270067588426 0.14788814811751352 2.0263237957673672e-07 6.693291155481636 -0.27193257981016217 VSVADHSLHLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSVADHSLHLSK 12 0 Q13162;A6NG45 Q13162 PRDX4 Peroxiredoxin-4 0 8965600.0 3195700.0 1264200.0 4505700.0 False True 3094254.252737737 1769001.6527159093 3325522.0018973867 1.0 0.5717053313090644 1.0747410297505542 21.561160316238215 -6.681191835995929 1.8975985785836382 0.7292964200854978 1.072844093490307 0.3295117082067388 0.18147575752333212 0.435939578348229 3.0359956599212037 0.07670786797591313 0.2020074837887056 2.083570327813025e-07 6.681191835995929 0.3435476734048092 VSVADHSLHLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSVADHSLHLSK 12 0 Q13162;A6NG45 Q13162 PRDX4 Peroxiredoxin-4 0 16481600.0 3633900.0 6018600.0 6829100.0 False True 4977451.032455003 5752678.351151328 5216207.229729361 1.0 1.155747854402088 1.0479675632603054 22.246975692285154 -10.859744974809871 6.63423341282892 0.9880461079786698 1.1018577088311967 0.5435508807309979 0.044001119604330216 0.00841729464511228 0.0001779507214109493 0.04609526760940537 0.014201300286837632 1.3811950880286592e-11 10.859744974809871 0.11381160085252695 VSVADHSLHLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSVADHSLHLSK 12 0 Q13162;A6NG45 Q13162 PRDX4 Peroxiredoxin-4 0 3928780.0 3195700.0 0.0 733080.0 False True 2657366.1435142034 0.0 886363.6386210475 1.0 0.0 0.33354968444389305 21.34156559167249 -10.514238115138866 6.192176940678159 1.0008181611099827 0.1667748422219697 0.8927080728372516 0.1361710884589804 0.0015393440609657977 0.00012075784266484632 0.13195849277049285 0.04394902981971395 3.06028507939527e-11 10.514238115138866 -0.834043318888013 VSVADHSLHLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSVADHSLHLSK 12 0 Q13162;A6NG45 Q13162 PRDX4 Peroxiredoxin-4 0 4354200.0 2306600.0 0.0 2047600.0 False True 2985939.169883464 0.0 1674957.8101502059 1.0 0.0 0.560948403451761 21.509753344240238 -9.9332429687591 5.993283325847177 1.0000002908501164 0.280474201725667 0.6868877160846831 0.22900622674837595 8.901197909704247e-07 1.5822331955369963e-07 0.22173441810432742 0.07391144186441014 1.166157020703153e-10 9.9332429687591 -0.7195260891244495 VSVENIK(ub)QLLQSAHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSVENIKQLLQSAHK 15 1 Q6FI81;H3BV90;H3BT65;H3BUG4;H3BQ23;H3BPG7 Q6FI81 CIAPIN1 Anamorsin 1 6430000.0 2174000.0 2313900.0 1942100.0 True False 2850135.0530459466 1968675.1395115547 1741150.121938661 1.0 0.6907304751778786 0.6109009185645043 21.442598852020268 -13.999999999999998 0.19014715652220035 2.658714137045792 0.5537151307432073 0.9994893263781491 0.0037920067897713006 12.353043687456749 0.1382824725019608 7.592151104580706 0.0548353203567674 1.0000000000000041e-14 13.999999999999998 -2.1049990063025845 VSVENIK(ub)QLLQSAHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSVENIKQLLQSAHK 15 1 Q6FI81;H3BV90;H3BT65;H3BUG4;H3BQ23;H3BPG7 Q6FI81 CIAPIN1 Anamorsin 1 11825300.0 2895400.0 2708400.0 6221500.0 True False 2803487.11186183 3789878.244119411 4591902.5090007335 1.0 1.3518443612899316 1.6379253143600845 21.418791006813166 -6.973482281939037 0.15370375704541028 0.6841796205959627 2.3131383823954947 0.9999983789355482 0.00033212121857460183 0.07518803117198397 0.004714983096626972 0.014074467248751981 0.03516277955575443 1.06296194841435e-07 6.973482281939037 1.628958761799532 VSVENIK(ub)QLLQSAHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSVENIKQLLQSAHK 15 1 Q6FI81;H3BV90;H3BT65;H3BUG4;H3BQ23;H3BPG7 Q6FI81 CIAPIN1 Anamorsin 1 27008900.0 6622000.0 6140900.0 14246000.0 True False 10046058.133047044 5045008.415929309 11430271.855756385 1.0 0.5021878580747492 1.1377867522143732 23.260126192732884 -6.697811991908032 1.838863244706808 0.690209788855034 1.1358067313931417 0.4070717993557471 0.2102192412173571 0.4001137495171891 2.6288242139582305 0.0912595050471933 0.23531468804035932 2.005339960438937e-07 6.697811991908032 0.44559694253810767 VSVENIK(ub)QLLQSAHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSVENIKQLLQSAHK 15 1 Q6FI81;H3BV90;H3BT65;H3BUG4;H3BQ23;H3BPG7 Q6FI81 CIAPIN1 Anamorsin 1 5951600.0 2174000.0 1200000.0 2577600.0 True False 2977786.550140946 1146980.0321306589 1968823.9673383601 1.0 0.3851787268218971 0.6611702800676464 21.50580891354316 -10.428514201754599 6.08396986868426 1.0001590219566414 0.5231745034448051 0.7991905131680843 0.1126730797950437 0.0002431132380919422 2.283652155078713e-05 0.10913107813171045 0.036365080134341914 3.728084936268613e-11 10.428514201754599 -0.4769845185118363 VSVENIK(ub)QLLQSAHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSVENIKQLLQSAHK 15 1 Q6FI81;H3BV90;H3BT65;H3BUG4;H3BQ23;H3BPG7 Q6FI81 CIAPIN1 Anamorsin 1 9511300.0 2895400.0 3747500.0 2868400.0 True False 2407653.38796853 3727311.4736794885 3468169.178016875 1.0 1.548109662422973 1.4404769371488146 21.199196282247442 -10.006227669713395 4.596271036053811 0.9999876165618096 1.4942932998021425 0.9656596601160702 0.04394087621615116 15151334.311265813 0.9234601649416803 2144.9154831231904 0.015042130668845324 9.857625849319911e-11 10.006227669713395 0.49430568324033297 VSVENIK(ub)QLLQSAHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSVENIKQLLQSAHK 15 1 Q6FI81;H3BV90;H3BT65;H3BUG4;H3BQ23;H3BPG7 Q6FI81 CIAPIN1 Anamorsin 1 34364300.0 6622000.0 6277300.0 21465000.0 True False 8572309.539134791 5927962.736809828 17558590.249499 1.0 0.6915245780319946 2.0482916732462275 23.031252514825333 -6.846944031567221 1.249782974997542 0.835724535220048 2.0994048234235176 0.9357352447466556 0.14720976290594504 0.16085016151183074 0.485019714776987 0.09223859137275545 0.2130658129742116 1.4225120974021644e-07 6.846944031567221 1.2636802882034697 up VSVFFGGLSIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSVFFGGLSIK 11 0 O00148;O00148-2;O00148-3;K7EQN7;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 103432000.0 19542000.0 57407000.0 26483000.0 False True 25619751.24499721 48842099.3707333 23742793.202874016 1.0 1.9064236379059587 0.9267378506460047 24.61075313211002 -6.6636155568677315 1.9600165184819245 1.5817196582881448 0.9307958130326669 0.25102831393795866 0.38560618960842774 0.4759832618919874 3.5188326080893866 0.1587366460881502 0.42766523229673503 2.1696238342880423e-07 6.6636155568677315 -0.6509238452554779 VSVFFGGLSIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSVFFGGLSIK 11 0 O00148;O00148-2;O00148-3;K7EQN7;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 113345000.0 46325000.0 25669000.0 41351000.0 False True 44854438.23202294 35918765.56206659 30519932.596590754 1.0 0.8007850945823037 0.6804216884562753 25.41874740740598 VSVFFGGLSIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSVFFGGLSIK 11 0 O00148;O00148-2;O00148-3;K7EQN7;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 350843000.0 94043000.0 113430000.0 143370000.0 False True 142670106.46423167 93187530.2673649 115032856.6586967 1.0 0.6531678750147119 0.8062856299019878 27.088107839016295 -10.012536051694275 4.591591759100364 1.0000075270964965 0.7297267525154848 0.8059857545269543 0.06251006173615753 43135596.39887466 5.286456447256283 3604.004654514036 0.02139885679291953 9.715472980540931e-11 10.012536051694275 -0.27028077458101174 VSVFFGGLSIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSVFFGGLSIK 11 0 O00148;O00148-2;O00148-3;K7EQN7;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 125540000.0 19542000.0 37157000.0 68841000.0 False True 26767205.50269293 35515280.87823245 52582173.62489916 1.0 1.3268206453101508 1.9644252224838747 24.67396319363291 -6.960527734099712 0.427930869798688 0.9741104881602758 2.3415031749657955 0.9997892748201788 0.005813534161465398 0.07951313453908175 0.02043868897471305 0.008298283127221827 0.05296684357095526 1.0951466169342486e-07 6.960527734099712 1.3673926868055197 VSVFFGGLSIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSVFFGGLSIK 11 0 O00148;O00148-2;O00148-3;K7EQN7;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 103727000.0 46325000.0 20238000.0 37164000.0 False True 38521290.045465946 20128973.877071537 44934820.57307883 1.0 0.5225415310160613 1.1664931397687648 25.199152682840257 -6.708152220532039 1.801971100367836 0.7059085078734932 1.1648858702517821 0.4561954281248839 0.20125852846751124 0.3788249363223623 2.396710403447555 0.08892259396563729 0.22639761252268242 1.958158217330765e-07 6.708152220532039 0.4589773623782889 VSVFFGGLSIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSVFFGGLSIK 11 0 O00148;O00148-2;O00148-3;K7EQN7;A0A0D9SEM9 O00148 DDX39A ATP-dependent RNA helicase DDX39A 0 302420000.0 94043000.0 122120000.0 86257000.0 False True 121740517.36467116 115323914.64789236 70559111.07156011 1.0 0.9472927924434722 0.5795860950730296 26.859234161108745 -6.932735049529497 0.7239923088127084 1.0050638495018744 0.498556955890763 0.9970489438743858 0.010158727737762609 0.09124252754890069 0.07090463958137595 0.009410478796291205 0.03278516197683216 1.1675216709548741e-07 6.932735049529497 -0.5065068936111115 VSVFQTQLPSLGAGLLQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSVFQTQLPSLGAGLLQSR 19 0 O95487-2;O95487;O95487-3 O95487-2 SEC24B Protein transport protein Sec24B 0 3964400.0 2268700.0 1695700.0 0.0 False True 2196681.3603235963 2372801.8529586825 0.0 1.0 1.0801757122431 0.0 21.066894184092074 -6.9709592164271355 1.168052176194578 1.0508286290682725 3.758039537960119e-21 0.9777588958877208 0.07328372468606774 0.09985378454884392 0.2691555228596637 0.05250742498533078 0.09816704867013229 1.0691552763647467e-07 6.9709592164271355 -1.0508286290682725 down VSVFQTQLPSLGAGLLQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSVFQTQLPSLGAGLLQSR 19 0 O95487-2;O95487;O95487-3 O95487-2 SEC24B Protein transport protein Sec24B 0 2101410.0 677560.0 557550.0 866300.0 False True 928072.2423705164 532915.5974287076 661697.782008544 1.0 0.5742177958770913 0.7129808993300037 19.823877585450354 -10.930577896416208 11.391771299566363 1.0576896312783757 0.6435993476035475 0.8979138202744097 0.05664979976411167 0.029344304240124592 0.00017882558748713419 0.01939181428891913 0.01828364425436579 1.1733352105443009e-11 10.930577896416208 -0.41409028367482814 VSVGAPDLSLEASEGSIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSVGAPDLSLEASEGSIK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 17760200.0 2016300.0 7466100.0 8277800.0 False True 2643388.825876976 6352186.982629859 7421292.662264483 1.0 2.4030467710411254 2.8074918792177237 21.33395722128278 -10.043271129362344 0.3000924786921095 1.4800259456327592e-16 2.9478779483562945 0.9989093312410322 0.025579236967534613 1.4610817333905193 0.1355474565104856 1.3850756865594462 0.1438839570386494 9.051673299265148e-11 10.043271129362344 2.9478779483562945 VSVGAPDLSLEASEGSIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSVGAPDLSLEASEGSIK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 19538500.0 6138000.0 4248000.0 9152500.0 False True 5943152.5497713275 5944248.553027346 6755185.68088552 1.0 1.0001844144579564 1.1366333985731927 22.502796982070475 -6.907192437644058 0.914641296563603 0.9953910557345276 1.1532478793372447 0.9898182423162897 0.006494847177816596 0.10630401423724466 0.1490545193555643 0.00524467991159942 0.014210975422625777 1.238247792340527e-07 6.907192437644058 0.15785682360271713 VSVGAPDLSLEASEGSIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSVGAPDLSLEASEGSIK 18 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 7958700.0 2016300.0 0.0 5942400.0 False True 2761780.598458691 0.0 4538927.507569625 1.0 0.0 1.6434786710076583 21.397167282805672 -6.74201902955167 1.6794241359354487 0.40640003071017555 1.6448527279682963 0.6139392314482184 0.4201419901969536 0.3141661569290431 1.7406278720276722 0.19785373972318213 0.48442092086364447 1.8112607265761325e-07 6.74201902955167 1.2384526972581207 VSVGAPDLSLEASEGSIK(ub)LPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSVGAPDLSLEASEGSIKLPK 21 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 13852100.0 4036200.0 4092300.0 5723600.0 True False 3908073.040304183 5726376.731062573 4224417.455680564 1.0 1.4652686047589487 1.0809463927910004 21.89802600026914 -10.092303628548198 5.663843701830055 0.9999980262904349 1.273107498775019 0.4023820774582829 0.1568988860233626 3.910332704333598e-06 6.26710090358093e-07 0.1519177909683538 0.050638897717225385 8.08530433192416e-11 10.092303628548198 0.27310947248458417 VSVGAPDLSLEASEGSIK(ub)LPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSVGAPDLSLEASEGSIKLPK 21 1 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 1 14544300.0 4468200.0 4169200.0 5906900.0 True False 6778586.0691756 3425173.685891722 4739398.625913754 1.0 0.5052932353351803 0.6991721544210107 22.692552945381973 -10.153336423257874 5.301403802804406 1.0000129158673952 0.6022326948779176 0.8487651681319959 0.07915073727439538 1.2083298215445747e-05 1.9297856769910995e-06 0.07663985831225212 0.025545790608557672 7.02527900599797e-11 10.153336423257874 -0.3977802209894775 VSVHVIEGDHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSVHVIEGDHR 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 30717900.0 11614000.0 7298900.0 11805000.0 False True 15226066.470136004 6209932.570889362 10583531.841556003 1.0 0.40784877585221085 0.6950929750841596 23.86003994569565 -10.489343647073898 6.283163923468362 1.0002774936660335 0.5514708754682063 0.7647614517724584 0.11726695328210437 0.00045611092052469474 3.7069786784511565e-05 0.11361164581913763 0.037847746426839426 3.240830765008587e-11 10.489343647073898 -0.4488066181978272 VSVHVIEGDHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSVHVIEGDHR 11 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 23739900.0 11614000.0 5330300.0 6795600.0 False True 15908009.656548759 5094789.721055049 5190619.2397752 1.0 0.3202656920036321 0.3262896711681595 23.92325000721854 -9.744578653151255 6.17873620974629 1.0000000118438606 0.32327768158599945 0.9999405730048173 0.0024592792003006736 3.9871691134404864e-10 8.614006667910707e-11 0.0023811868800687227 0.0007937289481954482 1.8006170031355348e-10 9.744578653151255 -0.6767223302578611 VSVHVLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSVHVLAR 8 0 A0A3B3ISG5;P14735;P14735-2 A0A3B3ISG5 IDE Insulin-degrading enzyme 0 9722500.0 3276800.0 2677700.0 3768000.0 False True 4295916.532576336 2278197.597592849 3378123.505208221 1.0 0.5303170069336925 0.786356876254833 22.034534532105596 -10.08862664914563 5.2486582418074965 1.0000056248477904 0.6583369415938282 0.7036345530579498 0.10452783894246716 6.880177081479185e-06 1.1947807382159032e-06 0.10121031087653595 0.0337362149530497 8.154049637073602e-11 10.08862664914563 -0.34166868325396227 VSVHVLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSVHVLAR 8 0 A0A3B3ISG5;P14735;P14735-2 A0A3B3ISG5 IDE Insulin-degrading enzyme 0 6339100.0 1670200.0 1117300.0 3551600.0 False True 1617180.4152212597 1563443.716642527 2621329.4142838567 1.0 0.9667713644854025 1.6209257727902988 20.625049206469463 -6.894936596465185 0.9927190763608267 0.9688956383233494 1.682947154796881 0.9838739421545124 0.03820386531124622 0.11523045748954124 0.19918281113741856 0.02911560957740638 0.07400201944488045 1.2736890158940768e-07 6.894936596465185 0.7140515164735317 VSVHVLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSVHVLAR 8 0 A0A3B3ISG5;P14735;P14735-2 A0A3B3ISG5 IDE Insulin-degrading enzyme 0 9363500.0 2768800.0 3209300.0 3385400.0 False True 4200472.026393938 2636575.3406246514 2716274.2061264655 1.0 0.6276854896443922 0.646659277590371 22.00212002861397 -10.171841570634943 4.917720708759756 1.0000306936458228 0.6371723836164875 0.9979531826659647 0.007746016495661071 2.6069249047224925e-06 4.3901281085689203e-07 0.007500681728269968 0.0025000160734874825 6.732222009973202e-11 10.171841570634943 -0.3628583100293352 VSVHVLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSVHVLAR 8 0 A0A3B3ISG5;P14735;P14735-2 A0A3B3ISG5 IDE Insulin-degrading enzyme 0 8190600.0 3276800.0 1934000.0 2979800.0 False True 4488321.512190363 1848549.4851172448 2276032.6109073744 1.0 0.4118576354426818 0.5071010632205443 22.097744593628487 -10.819579319733132 7.344914843777977 1.025564526789045 0.4594793493316152 0.9772432926906879 0.038882966568230766 0.014362753601085581 0.00035280661099392006 0.033219795651234785 0.012549423497491463 1.5150280730419352e-11 10.819579319733132 -0.5660851774574298 VSVHVLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSVHVLAR 8 0 A0A3B3ISG5;P14735;P14735-2 A0A3B3ISG5 IDE Insulin-degrading enzyme 0 5122100.0 1670200.0 2130100.0 1321800.0 False True 1388845.302405555 2118624.7285082564 1598182.2686873183 1.0 1.5254576768475827 1.1507273458888332 20.40545448190374 -10.053920217654435 8.82958500541455 0.9999999985022032 1.3380925113682078 0.5204655324977814 0.1529830169988671 4.61033868061438e-09 4.999639295550727e-10 0.1481251692722945 0.04937505642409821 8.832421420783696e-11 10.053920217654435 0.3380925128660046 VSVHVLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSVHVLAR 8 0 A0A3B3ISG5;P14735;P14735-2 A0A3B3ISG5 IDE Insulin-degrading enzyme 0 9960900.0 2768800.0 4736800.0 2455300.0 False True 3584266.1812075526 4473192.916018158 2008460.5935054705 1.0 1.2480080133197928 0.5603547537947677 21.77324635070642 -6.80914470007244 1.4181088836271085 1.135298263698892 0.5485560411787221 0.8575926015594776 0.1073025750338252 0.20796527528612457 0.8244436830742765 0.05949924206411034 0.13768915409573182 1.551869865244903e-07 6.80914470007244 -0.5867422225201698 VSVLNVAVLENPSPFHSPFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSVLNVAVLENPSPFHSPFR 20 0 Q9NVP2;K7ES22;K7EM93;K7EIL9;K7ELW9 Q9NVP2 ASF1B Histone chaperone ASF1B 0 18706800.0 10960000.0 3700100.0 4046700.0 False True 10612080.799200686 5177569.225766593 2986747.871602227 1.0 0.48789387526681605 0.2814479015111902 23.33920422945188 -13.271858430612692 0.1341749933408125 3.0166702321021983 6.308124811805635e-19 0.9996458137113606 0.0056848125821757 9.213732977532489 0.10744621055783521 5.09111197763364 0.24017883068467197 5.347386427183393e-14 13.271858430612692 -3.0166702321021983 VSVLNVAVLENPSPFHSPFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSVLNVAVLENPSPFHSPFR 20 0 Q9NVP2;K7ES22;K7EM93;K7EIL9;K7ELW9 Q9NVP2 ASF1B Histone chaperone ASF1B 0 40885500.0 8094500.0 17883000.0 14908000.0 False True 12279948.287216742 14691638.92948326 11961427.265591478 1.0 1.1963925731492742 0.9740616968267822 23.549801149517915 -6.673556634715637 1.9252102696664244 1.124972009651218 0.974952927645148 0.29479405153467086 0.0833555512309627 0.45294614984667414 3.2400295758068927 0.03481845948894995 0.09258187805227677 2.120524845361412e-07 6.673556634715637 -0.15001908200606995 VSVLNVAVLENPSPFHSPFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSVLNVAVLENPSPFHSPFR 20 0 Q9NVP2;K7ES22;K7EM93;K7EIL9;K7ELW9 Q9NVP2 ASF1B Histone chaperone ASF1B 0 8990000.0 2007100.0 1537500.0 5445400.0 False True 2749179.109838037 1469568.1661674085 4159308.67153333 1.0 0.5345479895829652 1.5129274977570917 21.390569471248696 -6.777346313593997 1.5462376233290598 0.7355364460259048 1.520037082515813 0.7578575196744219 0.1966244783875221 0.25473121570937984 1.2027498336010718 0.10017594646306661 0.2369001924160579 1.6697585902096414e-07 6.777346313593997 0.7845006364899081 VSVLNVAVLENPSPFHSPFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSVLNVAVLENPSPFHSPFR 20 0 Q9NVP2;K7ES22;K7EM93;K7EIL9;K7ELW9 Q9NVP2 ASF1B Histone chaperone ASF1B 0 30299200.0 8094500.0 12645000.0 9559700.0 False True 10478489.816449191 11941294.634151654 7819932.6908053 1.0 1.1396007290483925 0.7462843241522769 23.320927471610364 -6.810744924540591 1.4112740555180083 1.0760151562093687 0.7392772228184201 0.8617917980896977 0.06052606841399948 0.20578763980931658 0.8076500554481553 0.033720340696289514 0.07798066003858911 1.5461622849652112e-07 6.810744924540591 -0.3367379333909486 VSVSFIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSVSFIR 7 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;E7ERV5 G3V394 MYO5A Unconventional myosin-Va 0 16256500.0 4086500.0 4803200.0 7366800.0 False True 5357441.073722294 4086581.2827269565 6604554.203335437 1.0 0.7627860440259855 1.2327814925916978 22.353112646168853 -6.7694651212830985 1.5763229126299927 0.8638507329376535 1.2353840022361906 0.7286004853159429 0.09996063298712532 0.2672813669439898 1.3105923904937495 0.049985160487209156 0.11905254209085743 1.7003365042471966e-07 6.7694651212830985 0.37153326929853714 VSVSFIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSVSFIR 7 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;E7ERV5 G3V394 MYO5A Unconventional myosin-Va 0 8365800.0 2360000.0 1327500.0 4678300.0 False True 2285083.091798686 1857577.672821045 3452912.884008381 1.0 0.8129147160941385 1.5110666637905261 21.123815195853194 -6.83541411862572 1.3037439935618123 0.9003479312585132 1.531990121639081 0.9162336774237652 0.08540088979647266 0.1742305472020094 0.5772747864462476 0.051402381882138026 0.11830083616269318 1.4607835896273245e-07 6.83541411862572 0.6316421903805678 VSVSFIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSVSFIR 7 0 G3V394;Q9Y4I1-3;F8WE88;Q9Y4I1-2;Q9Y4I1;A0A087WY00;F8W6H6;E7ERV5 G3V394 MYO5A Unconventional myosin-Va 0 6708500.0 2360000.0 2122500.0 2226000.0 False True 1962444.5657269212 2111065.6712167375 2691446.3081388804 1.0 1.0757326388145718 1.3714763490106154 20.90422047128747 -6.945427161045954 0.6069825503261717 0.9967134476765335 1.465817199139626 0.9987917346582832 0.005571195209966257 0.08537574122964024 0.043975191079255 0.005679289517839218 0.024911676225359076 1.1338949966345341e-07 6.945427161045954 0.4691037514630926 VSVWSK(ub)VLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSVWSKVLR 9 1 Q9BUV8-4;Q9BUV8-3;Q9BUV8-2;Q9BUV8;Q9BUV8-5 Q9BUV8-4 C20orf24 Uncharacterized protein C20orf24 1 40621100.0 1447100.0 21252000.0 17922000.0 True False 2195356.4971809667 17459414.557366118 14379708.844508339 1.0 7.952883542962413 6.550056386274013 21.066023802913353 -10.471917997538418 6.672351014290817 0.9981274618421545 7.251469964618184 0.9636080187454552 0.5727017885343209 0.015944521919818863 0.001261920823843423 0.5542206081412557 0.18483870744471873 3.373510004672697e-11 10.471917997538418 6.253342502776029 VSVWSK(ub)VLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSVWSKVLR 9 1 Q9BUV8-4;Q9BUV8-3;Q9BUV8-2;Q9BUV8;Q9BUV8-5 Q9BUV8-4 C20orf24 Uncharacterized protein C20orf24 1 28296700.0 1447100.0 16880000.0 9969600.0 True False 1873299.4766055488 15940613.16128748 8155235.09673447 1.0 8.509377897319519 4.35340702251831 20.837150125005802 -9.757374223556683 8.388829247527793 1.0000305338081348 6.431392459918907 0.6948687613777988 1.696668004946787 0.0 0.0 1.6427916583228157 0.5475972439196943 1.7483395273996715e-10 9.757374223556683 5.431361926110773 VSVYLQNWSHVLSYVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSVYLQNWSHVLSYVSK 17 0 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07;Q13098-6;J3KSA5 Q13098-7 GPS1 COP9 signalosome complex subunit 1 0 10971700.0 2392400.0 2434300.0 6145000.0 False True 2316454.571533549 3406328.6847067955 4535440.153951545 1.0 1.470492331931087 1.95792320284916 21.143486958983978 -6.970681107885027 0.24136396396375714 0.8279112669252281 2.6146263356709243 0.999987218345249 0.001398194332335995 0.0760822976103466 0.008235320579951529 0.011539804692067836 0.04740491062576691 1.069840149076473e-07 6.970681107885027 1.7867150687456963 VSVYLQNWSHVLSYVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VSVYLQNWSHVLSYVSK 17 0 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07;Q13098-6;J3KSA5 Q13098-7 GPS1 COP9 signalosome complex subunit 1 0 45002000.0 13978000.0 13683000.0 17341000.0 False True 21205647.9286819 11241161.744233048 13913543.749169704 1.0 0.5301022530431012 0.6561244342056065 24.337945228693417 -10.287330277669259 8.37516936210464 1.0000004372641018 0.5931133436243661 0.9328825674244261 0.05144834002012003 4.2002288447276874e-07 3.58068240185155e-08 0.049814693721470085 0.01660488034066179 5.16023787825023e-11 10.287330277669259 -0.40688709363973574 VSVYLQNWSHVLSYVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSVYLQNWSHVLSYVSK 17 0 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07;Q13098-6;J3KSA5 Q13098-7 GPS1 COP9 signalosome complex subunit 1 0 12018800.0 2392400.0 3286300.0 6340100.0 False True 1989386.6012902907 3268596.0496205264 7665785.5966897225 1.0 1.643017022181891 3.8533413222536996 20.923892234418254 -6.948357634887343 0.5765919566300022 0.9732278013666085 4.631818654249331 0.9990660200902602 0.03734704174906528 0.08415200640772204 0.038743882625141224 0.03927574250230659 0.1844725156371111 1.1262696083351772e-07 6.948357634887343 3.658590852882723 VSVYLQNWSHVLSYVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSVYLQNWSHVLSYVSK 17 0 Q13098-7;Q13098;Q13098-5;C9JFE4;A8K070;A0A096LPJ3;A0A096LP07;Q13098-6;J3KSA5 Q13098-7 GPS1 COP9 signalosome complex subunit 1 0 35403400.0 13978000.0 12834000.0 8591400.0 False True 18094796.54757265 12119776.618007293 7027853.355208294 1.0 0.669793472733636 0.3883908468786323 24.109071550785867 -7.392741789011121 0.21431246611491056 1.1683683241315825 4.7304587044041964e-15 0.9999553277590681 0.0016706098030478689 0.11869229842867872 0.016468998501029918 0.023401318890527115 0.05578367841029119 4.048165049376266e-08 7.392741789011121 -1.1683683241315779 down VSWQDLK(ub)DFMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSWQDLKDFMR 11 1 Q13243-3;Q13243 Q13243-3 SRSF5 Serine/arginine-rich splicing factor 5 1 8436500.0 3405300.0 2946700.0 2084500.0 True False 3297200.615466978 4123332.6768374955 1538506.916340439 1.0 1.250555594796137 0.46661004159813385 21.65281023859944 -6.820699675074434 1.368692145301014 1.1349542670132866 0.44921479596223446 0.8860260286462636 0.11036619479651197 0.19256629010879361 0.7086155168872348 0.06336099457018896 0.14602125602596705 1.5111247715218132e-07 6.820699675074434 -0.6857394710510522 down VSWQDLK(ub)DFMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSWQDLKDFMR 11 1 Q13243-3;Q13243 Q13243-3 SRSF5 Serine/arginine-rich splicing factor 5 1 7148400.0 3405300.0 2062400.0 1680700.0 True False 2831657.830368596 2051289.4418456538 2032126.599321211 1.0 0.7244128933398136 0.7176455352505248 21.433215514033716 VSYFAVFDGHGGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSYFAVFDGHGGIR 14 0 Q9H0C8;E9PC05 Q9H0C8 ILKAP Integrin-linked kinase-associated serine/threonine phosphatase 2C 0 5760400.0 1509400.0 2741500.0 1509500.0 False True 1978838.017050392 2332478.886283301 1353311.4201464471 1.0 1.1787113781854854 0.6838919651259078 20.9162220909756 -6.80900265958644 1.4186629594629998 1.0975126471456838 0.6754269209280759 0.8572158540219137 0.07730744706678062 0.208167934882567 0.8259113369252545 0.042849911819535035 0.0991688997312774 1.552377503286983e-07 6.80900265958644 -0.42208572621760787 VSYFAVFDGHGGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSYFAVFDGHGGIR 14 0 Q9H0C8;E9PC05 Q9H0C8 ILKAP Integrin-linked kinase-associated serine/threonine phosphatase 2C 0 4740700.0 1509400.0 1860100.0 1371200.0 False True 2067465.9700012628 1777914.6314718672 1047350.8007504501 1.0 0.8599486798183098 0.5065867182083826 20.979432152498493 -6.955264218837702 0.49770821145314476 1.0072195076563122 0.3441343381061985 0.9995522609191396 0.0043930966113805295 0.08143823871123469 0.027728117218439225 0.005174446847366598 0.02914717044187667 1.1085002136672992e-07 6.955264218837702 -0.6630851695501137 VSYFPTVPGVYIVSTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSYFPTVPGVYIVSTK 16 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4;H7C5L4 O75369-2 FLNB Filamin-B 0 20355200.0 5140500.0 9808500.0 5406200.0 False True 6739245.280672811 8345110.033233554 4846818.283932234 1.0 1.2382855476660173 0.719193037510033 22.68415560423329 -6.781882278098209 1.528413352277696 1.1345942606704975 0.7148271268682812 0.7740226594801073 0.10085251453896264 0.24766737729674343 1.1428611948215908 0.051963511935128916 0.12242693627960163 1.6524096474472721e-07 6.781882278098209 -0.4197671338022163 VSYFPTVPGVYIVSTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VSYFPTVPGVYIVSTK 16 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4;H7C5L4 O75369-2 FLNB Filamin-B 0 35601200.0 15569000.0 6899200.0 13133000.0 False True 15074770.617039744 9654086.53885271 9693073.318445174 1.0 0.6404134951108462 0.6429997221641717 23.84563271395368 -10.460802642624387 9.008747924278309 1.0000049744574881 0.6417066086375112 0.9999609237406314 0.0010558227732715094 1.054897529963819e-07 6.312514500270074e-09 0.0010223101910965175 0.0003407653347855906 3.4609661952686674e-11 10.460802642624387 -0.358298365819977 VSYFPTVPGVYIVSTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSYFPTVPGVYIVSTK 16 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4;H7C5L4 O75369-2 FLNB Filamin-B 0 26383500.0 5140500.0 8041000.0 13202000.0 False True 7041081.766789116 7685722.031968857 10083959.503724797 1.0 1.0915541512698141 1.4321605454559716 22.74736566575618 -6.9465425613250735 0.5956016740678061 0.9961234150195711 1.544895582069894 0.9989011978174352 0.0061635160174767075 0.08490467838616823 0.04194361269996358 0.006353626595527527 0.02858337149205468 1.1309865460077478e-07 6.9465425613250735 0.5487721670503228 VSYFPTVPGVYIVSTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VSYFPTVPGVYIVSTK 16 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4;H7C5L4 O75369-2 FLNB Filamin-B 0 29455400.0 15569000.0 8976500.0 4909900.0 False True 12946313.323645119 8928141.812804263 5936537.389187381 1.0 0.6896281272984429 0.45855041823720594 23.626037989387957 -7.602321607164509 0.15911304197525464 1.287813478341348 1.0603613225157457e-13 0.9999742206028116 0.0011263151690351983 0.13481528766581635 0.016824921280430793 0.04692575508365584 0.0770610696329384 2.4984944716918698e-08 7.602321607164509 -1.2878134783412418 down VSYK(ub)GDPIVQHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VSYKGDPIVQHR 12 1 G8JLH9;P40763-3;P40763-2;P40763 G8JLH9 STAT3 Signal transducer and activator of transcription;Signal transducer and activator of transcription 3 1 5135970.0 2254000.0 2279900.0 602070.0 True False 2955015.8277670504 1939747.806980596 539773.5718632463 1.0 0.6564255219053635 0.1826635129298528 21.49473442716518 -7.396419575648803 0.4382548452661885 1.0242224379136755 1.0235202027486143e-19 0.9988302650986426 0.011460343125958117 0.11104238527750335 0.04631924252550251 0.01578161937042222 0.06073408104888207 4.0140282472593885e-08 7.396419575648803 -1.0242224379136755 down VSYK(ub)GDPIVQHRPMLEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VSYKGDPIVQHRPMLEER 18 2 G8JLH9;P40763-3;P40763-2;P40763 G8JLH9 STAT3 Signal transducer and activator of transcription;Signal transducer and activator of transcription 3 1 14307800.0 3067700.0 4701300.0 6538800.0 True False 3971198.1234073956 4439668.522225163 5348805.493753744 1.0 1.11796701757499 1.3468996830519058 21.921142908158636 -6.960629813737748 0.4264660374880068 0.9905581477255301 1.4830367191657718 0.9997928447151325 0.0020728000753788525 0.07947693045355297 0.020305787260185254 0.002975706433811398 0.01902461610984376 1.0948892361989855e-07 6.960629813737748 0.49247857144024176 VSYPLCFIFSSPVGCKPEQQMMYAGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VSYPLCFIFSSPVGCKPEQQMMYAGSK 27 1 M0QYJ8;O60234;M0QYG8;M0R1D2;M0R0C1;G3V4P8;P60983 M0QYJ8 GMFG;GMFB Glia maturation factor gamma;Glia maturation factor beta 0 5216900.0 764800.0 1198900.0 3253200.0 False True 1047567.22794287 1145928.633767874 2484861.1617571176 1.0 1.0938950772812532 2.3720302577970984 19.99861140160924 -6.921655870879573 0.8123543877827873 0.9734467301773149 2.586199084040439 0.9946286235393692 0.045866513600504435 0.0972071435742526 0.10063818832867133 0.03986925043985016 0.12138456016458933 1.197689188249176e-07 6.921655870879573 1.6127523538631243 up VTAAAMAGNK(ub)STPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTAAAMAGNKSTPR 14 1 P12270 P12270 TPR Nucleoprotein TPR 1 3817380.0 1523200.0 1521300.0 772880.0 True False 1996929.9506897826 1294327.9699809533 692909.7915884625 1.0 0.6481589249206586 0.346987530208116 20.92935229541354 -7.51382352003864 0.2359044675407313 1.1501034077025203 8.258761899619851e-14 0.9998935690358404 0.0027530509901307894 0.12774069728414697 0.02328816456408834 0.02895972233994568 0.06632913062082581 3.063207946387301e-08 7.51382352003864 -1.1501034077024377 down VTAAAMAGNK(ub)STPR ddPTM_RPMI8226_Bortezomib_2h_R1 2 VTAAAMAGNKSTPR 14 1 P12270 P12270 TPR Nucleoprotein TPR 1 10731360.0 3280400.0 3746760.0 3704200.0 True False 3176265.4976001787 5242860.807095277 2733958.8963819854 1.0 1.650636828393757 0.8607463382540353 21.59890007880198 -6.68785918799866 1.8738007360891187 1.4087151919524175 0.8635269076588149 0.36054169504738975 0.2752930130553244 0.42127634491496396 2.8660641217755245 0.11759952728290855 0.3070914031611207 2.0518273382788794e-07 6.68785918799866 -0.5451882842936026 VTAAAMAGNK(ub)STPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTAAAMAGNKSTPR 14 1 P12270 P12270 TPR Nucleoprotein TPR 1 3046320.0 1125000.0 1396400.0 524920.0 True False 935487.3459503338 1388877.3160363 634678.3450441429 1.0 1.4846564435624523 0.6784467452089286 19.835358613142667 -6.743930091704497 1.6724203921887384 1.2870502185920114 0.6775678805659033 0.6224057201816485 0.20362335730138167 0.31075136743233606 1.7080624871438816 0.0962649100177666 0.23520377099224052 1.8033079956235906e-07 6.743930091704497 -0.6094823380261081 VTAEVVLAHLGGGSTSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTAEVVLAHLGGGSTSR 17 0 P04843;F8WF32 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 39318000.0 15423000.0 14211000.0 9684000.0 False True 20219702.356544465 12090774.194044122 8681992.57548737 1.0 0.5979699394600994 0.42938280803511875 24.269258424464443 -13.999999999999988 0.11906529908008394 2.9175352110672828 0.15688733717093353 0.9996975403504996 0.0041628537046486894 11.96741749210851 0.10607302738287644 5.436848513642423 0.2417971430573408 1.0000000000000286e-14 13.999999999999988 -2.760647873896349 VTAEVVLAHLGGGSTSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTAEVVLAHLGGGSTSR 17 0 P04843;F8WF32 P04843 RPN1 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 0 32472100.0 15423000.0 9045800.0 8003300.0 False True 21125299.890903335 8646126.645539606 6113085.373137456 1.0 0.40927829144156547 0.28937271445646 24.332468485987334 -13.999999999999881 0.224164632591065 4.6311494294903355 0.22773954363844057 0.9995024043811763 0.006928782465149513 13.116270291314512 0.14995590783241786 21.12998813065702 0.06458244538657272 1.000000000000274e-14 13.999999999999881 -4.403409885851895 VTAFLDDLSQK(ub)LKPLGEAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTAFLDDLSQKLKPLGEAER 20 2 E9PCB6;Q9BYT8;H0YAK4 E9PCB6 NLN Neurolysin, mitochondrial 1 7043500.0 2305000.0 1983500.0 2755000.0 True False 1916709.6288137955 1972814.4918060764 3331057.7623192403 1.0 1.0292714463103119 1.7379042251594208 20.870200362354968 -6.915588015790522 0.8568113915344201 0.9817427623287255 1.84133452198959 0.9928648486442142 0.028817842818231607 0.10083818957108685 0.1195815494712515 0.024265815670058713 0.06988548800058003 1.2145404520867438e-07 6.915588015790522 0.8595917596608645 VTAPDVDLHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTAPDVDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 13147400.0 3535400.0 5491700.0 4120300.0 False True 4634943.636862297 4672359.766478944 3693970.8807084435 1.0 1.0080726180398554 0.7969829128729469 22.144120364417986 -6.898008663519348 0.9737864896262298 1.0092622744965456 0.7757013206665406 0.9855488187850279 0.011740190439333612 0.11288540676422115 0.18580864403597636 0.00907516450208615 0.02338435360421037 1.2647111181417792e-07 6.898008663519348 -0.23356095383000497 VTAPDVDLHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTAPDVDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 12902500.0 4280300.0 3130700.0 5491500.0 False True 4144424.2194177676 4380804.83638482 4053111.408531308 1.0 1.0570358159426692 0.9779673107645125 21.982740252832794 -6.713160575088818 1.7839834841002433 1.0349503727665272 0.9781354742625449 0.4801038059152348 0.02402301198987591 0.36874540537258543 2.289573545869848 0.010708452443932833 0.02710030016669182 1.935706127882503e-07 6.713160575088818 -0.05681489850398236 VTAPDVDLHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTAPDVDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 6417000.0 2881000.0 0.0 3536000.0 False True 4370687.629312677 0.0 2837108.0501161437 1.0 0.0 0.649121669342977 22.059428842495755 -10.297093853021243 7.496703112056179 1.0000036316797132 0.32456083467148855 0.5907744709490628 0.2650028118123193 1.6085318833548802e-05 1.5078859090579887e-06 0.2565892503771882 0.08552928973727085 5.045522497353014e-11 10.297093853021243 -0.6754427970082246 VTAPDVDLHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTAPDVDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 14459600.0 3535400.0 5077400.0 5846800.0 False True 4842532.920592592 4853063.67928351 4465906.258625822 1.0 1.0021746385339243 0.9222252758747005 22.207330425940878 -6.900646759725544 0.9571583164196457 1.003265271054713 0.9137217887106978 0.9868856534724917 0.004258518176426631 0.11093117715376662 0.1747419837704202 0.003332730043287494 0.008699786579558074 1.2570519910835328e-07 6.900646759725544 -0.08954348234401521 VTAPDVDLHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTAPDVDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 6924640.0 4280300.0 1655200.0 989140.0 False True 3559259.099441082 1646283.1090685255 1195964.6007333766 1.0 0.46253533757265514 0.3360150433895586 21.76314552826707 -13.999999999999932 0.20320195580803263 4.0247852889026845 0.2563915324173512 0.9994873468616182 0.006517596989386695 12.596042020543047 0.142919834355917 15.16376465577243 0.07867973449079829 1.0000000000001554e-14 13.999999999999932 -3.768393756485333 VTAPDVDLHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTAPDVDLHLK 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 11600500.0 2881000.0 6156400.0 2563100.0 False True 3729511.2930002036 5813790.928089461 2096642.0996268794 1.0 1.5588613282928445 0.562176096252074 21.830555164588205 -6.754549611800446 1.6330000079242175 1.3268076371950286 0.5594850168624755 0.6683284236446967 0.23490993351665052 0.2921684843933896 1.5342110600499346 0.11357360063269434 0.274422801573138 1.759747626858695e-07 6.754549611800446 -0.767322620332553 VTATALK(ub)TAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTATALKTAR 10 1 Q969E8 Q969E8 TSR2 Pre-rRNA-processing protein TSR2 homolog 1 4266780.0 1977200.0 1770000.0 519580.0 True False 1914434.868264563 2476770.230428063 383486.4109341163 1.0 1.293734392057567 0.20031311448153213 20.868487147856403 -6.8351915465704 1.3044446453529421 1.156485515778511 0.1676209627976011 0.915879671807937 0.13400850571580755 0.17449271501542338 0.5788035314281893 0.0806113682404041 0.18555093833664787 1.4615324200792908e-07 6.8351915465704 -0.9888645529809099 down VTAVPTLLK(ub)YGTPQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTAVPTLLKYGTPQK 15 1 Q9BRA2;I3L2R6 Q9BRA2 TXNDC17 Thioredoxin domain-containing protein 17 1 37815000.0 10152000.0 15437000.0 12226000.0 True False 13309370.312107863 13133859.772954706 10960970.800073164 1.0 0.9868130095536157 0.8235529212153408 23.665938980834067 -6.922950325540271 0.802558656814845 1.003233874258761 0.7953538463368865 0.994961550541623 0.00569634294887062 0.09646716461751972 0.0968514765496817 0.004986247406345228 0.015384381059670925 1.1941246802408087e-07 6.922950325540271 -0.20788002792187443 VTAVPTLLK(ub)YGTPQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTAVPTLLKYGTPQK 15 1 Q9BRA2;I3L2R6 Q9BRA2 TXNDC17 Thioredoxin domain-containing protein 17 1 65137000.0 17308000.0 17393000.0 30436000.0 True False 16758567.013920207 24338115.60329675 22463898.539571878 1.0 1.4522790393164717 1.3404426834891454 23.998395457025882 -10.092084235429734 4.999356738364984 0.9999885424089254 1.39636086140443 0.9436545568245909 0.04565700108383705 5.830830149898629e-06 1.0589221543951756e-06 0.04420847840398121 0.014735733735485085 8.089389827669867e-11 10.092084235429734 0.3963723189955046 VTAVPTLLK(ub)YGTPQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTAVPTLLKYGTPQK 15 1 Q9BRA2;I3L2R6 Q9BRA2 TXNDC17 Thioredoxin domain-containing protein 17 1 117719000.0 29545000.0 50970000.0 37204000.0 True False 44821925.02882434 41874005.269572295 29850613.092907544 1.0 0.934230407164434 0.6659823975367198 25.417701275797434 -6.944428100773189 0.6169979379403189 1.0029429395365597 0.5831316706605145 0.9986882132121717 0.005232583425174838 0.08580342475637626 0.045838500470759984 0.005284138835890009 0.02267647702755281 1.1365064353796446e-07 6.944428100773189 -0.41981126887604514 VTAVPTLLK(ub)YGTPQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTAVPTLLKYGTPQK 15 1 Q9BRA2;I3L2R6 Q9BRA2 TXNDC17 Thioredoxin domain-containing protein 17 1 42117000.0 10152000.0 14168000.0 17797000.0 True False 13905468.747484332 13542010.91268934 13593715.140720349 1.0 0.9738622378436005 0.9775805035827805 23.72914904235696 -9.89466836216326 5.110828553591569 1.0000000544582481 0.9757213707126393 0.9827127207646642 0.00151797563356565 9.418263032641456e-10 2.0569437475837867e-10 0.001469776871508914 0.000489924528767339 1.274475930363753e-10 9.89466836216326 -0.02427868374560882 VTAVPTLLK(ub)YGTPQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTAVPTLLKYGTPQK 15 1 Q9BRA2;I3L2R6 Q9BRA2 TXNDC17 Thioredoxin domain-containing protein 17 1 54571000.0 17308000.0 21084000.0 16179000.0 True False 14392368.874407448 20970416.30715366 19561954.096756056 1.0 1.4570510588040386 1.3591893223040705 23.77880073246016 -10.055548378112123 4.729952632659481 0.9999886693803032 1.408120190562255 0.9586595362044555 0.039951886687418225 5016247.24331999 10664190.637490703 437.59831171236846 0.013676595083238895 8.79937085882521e-11 10.055548378112123 0.40813152118195173 VTAVPTLLK(ub)YGTPQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTAVPTLLKYGTPQK 15 1 Q9BRA2;I3L2R6 Q9BRA2 TXNDC17 Thioredoxin domain-containing protein 17 1 95650000.0 29545000.0 38694000.0 27411000.0 True False 38246584.919018015 36540644.88524034 22422479.260611136 1.0 0.9553962781934707 0.5862609513525904 25.188827597889883 -6.9294707961297295 0.7511269092434518 1.0057251607988837 0.511491557552091 0.9964331153670447 0.011074004471064821 0.09291373859322352 0.07903429843450713 0.010057337441486175 0.033498166722326764 1.1763300836315863e-07 6.9294707961297295 -0.4942336032467928 VTAYTVDVTGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTAYTVDVTGR 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 23287700.0 5268300.0 7423400.0 10596000.0 False True 6906792.318289767 6315857.656186559 9499627.564009096 1.0 0.9144415185992544 1.3754036789050808 22.71958441294215 -6.858756428342086 1.1919745207803252 0.9537226792226855 1.3972041500690224 0.9521116428182961 0.04381142950684702 0.14809148438466518 0.40052162099955496 0.028681027746972655 0.06686041332913463 1.3843425621610315e-07 6.858756428342086 0.44348147084633693 VTAYTVDVTGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTAYTVDVTGR 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 9983500.0 0.0 1584100.0 8399400.0 False True 0.0 2216639.3909723694 6199345.1634012265 0.0 VTAYTVDVTGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTAYTVDVTGR 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 30389900.0 1991100.0 24557000.0 3841800.0 False True 3020644.268908179 20174611.48528326 3082466.5460792393 1.0 6.678910089792015 1.0204665864853415 21.5264248620625 -6.645333719820605 2.025225316535898 4.698530744934011 1.0441574899276398 0.17539464120461667 2.426613663048544 0.5200140350000574 4.082661920851536 0.9735655032308815 2.6873217964395546 2.2629047819272412e-07 6.645333719820605 -3.6543732550063712 VTAYTVDVTGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTAYTVDVTGR 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 19454200.0 5268300.0 5105200.0 9080700.0 False True 7216132.880454251 4879635.383361199 6936025.6828869665 1.0 0.6762119634157886 0.961183198507058 22.782794474465042 -10.223913583609002 7.45481603450721 1.000000297044942 0.8186975816694959 0.3505183554169161 0.11633901955738636 5.742952320612893e-07 5.989316719478046e-08 0.11264495595143724 0.03754825710498801 5.971540971382746e-11 10.223913583609002 -0.18130271537544607 VTAYTVDVTGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTAYTVDVTGR 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 4282000.0 0.0 2516600.0 1765400.0 False True 0.0 2503042.5762940124 2134536.9777126634 0.0 VTAYTVDVTGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTAYTVDVTGR 11 0 Q09666 Q09666 AHNAK Neuroblast differentiation-associated protein AHNAK 0 10452000.0 1991100.0 4945400.0 3515500.0 False True 2577518.200448698 4670184.142644016 2875715.072076118 1.0 1.8118918197477807 1.1156914708014514 21.297551184154948 -10.224327100574229 4.287591764970167 0.9997813725092549 1.4637916452909998 0.37174872269030734 0.2842226023328016 200278870.17147157 169.48964911276255 433129.94666262646 0.09729695664846104 5.965857826930622e-11 10.224327100574229 0.4640102727817449 VTCIDPNPNFEK(ub)FLIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTCIDPNPNFEKFLIK 16 1 Q9H8H3;H0YI09;F8VQX6 Q9H8H3 METTL7A Methyltransferase-like protein 7A 1 11528400.0 3595600.0 2272800.0 5660000.0 True False 3481459.64613193 3180340.8924954203 4177476.20363966 1.0 0.9135079006384385 1.199920903371963 21.73126087043482 -6.825710480684101 1.346909762726923 0.953629794960059 1.2069772890381096 0.8970300124607099 0.03848913922401438 0.18616541121664665 0.6620003819101534 0.022445597475510025 0.051673939371441706 1.4937899020970891e-07 6.825710480684101 0.2533474940780507 VTCIDPNPNFEK(ub)FLIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTCIDPNPNFEKFLIK 16 1 Q9H8H3;H0YI09;F8VQX6 Q9H8H3 METTL7A Methyltransferase-like protein 7A 1 33757800.0 3760400.0 9673400.0 20324000.0 True False 4867911.928565763 9135066.786398001 16625240.541850347 1.0 1.8765883443354476 3.4152714317386295 22.214871636026018 -6.9625144316523615 0.39841626568998734 0.9139248954551412 4.433974540985161 0.9998523876921372 0.01212896739537183 0.07881485335520896 0.017900042409587445 0.019803282674646164 0.12899339335435528 1.0901482660390534e-07 6.9625144316523615 3.5200496455300194 VTDAIVLLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTDAIVLLDR 10 0 P11172;P11172-3;E9PFD2 P11172 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 0 4936750.0 829450.0 1824600.0 2282700.0 False True 1087416.982405226 1552376.7922350958 2046508.1012045646 1.0 1.427581891172454 1.8819901972451754 20.052473833601415 -6.970353438419927 0.24960043885167957 0.8550814246980426 2.467792908445523 0.9999850092992109 0.0013943195925467569 0.07618817925926318 0.008618838909159538 0.010162493663894361 0.04357919838655925 1.0706476339546751e-07 6.970353438419927 1.6127114837474803 VTDAIVLLDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTDAIVLLDR 10 0 P11172;P11172-3;E9PFD2 P11172 UMPS Uridine 5-monophosphate synthase;Orotate phosphoribosyltransferase;Orotidine 5-phosphate decarboxylase 0 3652950.0 829450.0 1297200.0 1526300.0 False True 1136120.0800434265 1239885.4147332418 1165819.3751352178 1.0 1.0913330699038863 1.026140982466093 20.115683895124306 -10.56223028525786 4.710610469146155 0.9994909629978417 1.0587370261849953 0.5197762811969306 0.026614558248270397 0.0001435104073208133 1.3336826309905085e-05 0.025992070349674334 0.008589811738515283 2.74012083373121e-11 10.56223028525786 0.05924606318715364 VTDALNATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTDALNATR 9 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 67997300.0 1357300.0 40067000.0 26573000.0 False True 1779433.4441118955 34089159.77994277 23823480.866214987 1.0 19.157310936659655 13.388239355085934 20.762986542269992 -9.015646611878408 13.45601362804163 0.9999999805500491 16.27277514587283 0.903331625080718 2.355213610741261 0.0 0.0 2.2804257727904242 0.7601419242634746 9.646136164670471e-10 9.015646611878408 15.272775165322782 VTDALNATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTDALNATR 9 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 65877300.0 17536000.0 7639300.0 40702000.0 False True 16979329.278721105 10689712.328423219 30040925.166173447 1.0 0.6295721198963858 1.7692645376647145 24.01727613456452 -6.819183786870066 1.3753775723329236 0.8001743241549485 1.793717160492717 0.8824999366088018 0.16271189448274553 0.19454515078959356 0.7233441218294517 0.09297061098049397 0.2143329016028777 1.5164085104618878e-07 6.819183786870066 0.9935428363377684 VTDALNATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTDALNATR 9 0 P10809 P10809 HSPD1 60 kDa heat shock protein, mitochondrial 0 60615300.0 1357300.0 29726000.0 29532000.0 False True 1859130.4896533138 28412607.029263303 22557149.830631744 1.0 15.282739531941955 12.133171908141934 20.826196603792884 -9.583015823579647 12.120031406275526 1.000000000000048 13.707955720041946 0.9559595964577288 1.2858055981166898 0.0 0.0 1.2449759169915517 0.41499197233051716 2.6120661816720073e-10 9.583015823579647 12.707955720041898 VTDDLVCLVYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTDDLVCLVYK 11 0 P49458 P49458 SRP9 Signal recognition particle 9 kDa protein 0 39224900.0 9186900.0 16537000.0 13501000.0 False True 12044114.866066167 14069744.06072111 12104046.030736767 1.0 1.1681841477917216 1.0049759708651944 23.521825036595814 -10.863946223307119 2.896188151930308 0.9650590416214426 1.0865800593834694 0.27284575219049645 0.0666294594889628 50282330.20843344 13641022.392037109 11766926.699030139 0.024383884919174807 1.3678981956662758e-11 10.863946223307119 0.12152101776202673 VTDDLVCLVYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTDDLVCLVYK 11 0 P49458 P49458 SRP9 Signal recognition particle 9 kDa protein 0 37815900.0 9186900.0 15283000.0 13346000.0 False True 12583545.19663749 14607746.525877396 10193949.669497883 1.0 1.1608609734068267 0.8101015659896749 23.585035098118706 -6.782026626745431 1.5281337109693427 1.0908442929596553 0.8071523222670438 0.7744409314790472 0.06808623804788816 0.24744008591220357 1.1414468474424069 0.03508917112539296 0.08265104005106523 1.651860518982528e-07 6.782026626745431 -0.28369197069261154 VTDDLVCLVYK(ub)TDQAQDVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTDDLVCLVYKTDQAQDVK 19 1 P49458 P49458 SRP9 Signal recognition particle 9 kDa protein 1 11983200.0 3726800.0 5488800.0 2767600.0 True False 4885870.890382542 4669892.435174825 2481235.3006938086 1.0 0.9557953003562059 0.5078389004461676 22.220184310075094 -6.925981333446528 0.7790829071186108 1.0079220458462996 0.424632292368601 0.9956874588851067 0.014599836872957574 0.0947792610816558 0.08830448322100232 0.01299579929444422 0.041464117490554814 1.1858197151776814e-07 6.925981333446528 -0.5832897534776986 VTDK(ub)LTPIHDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTDKLTPIHDR 11 1 P28072;I3L3X7;A0A087X2I4 P28072 PSMB6 Proteasome subunit beta type-6;Proteasome subunit beta type 1 29352700.0 1091200.0 3417500.0 24844000.0 True False 1655430.1774057574 2807620.4239506237 19933572.510487985 1.0 1.6960065500016897 12.04132483662108 20.658774731472693 -6.920536048859975 0.8207333386512323 0.7761165269007002 13.73038883820408 0.9943286558835657 0.3802228604946692 0.09785762013091236 0.10398502126987264 0.3285334918916292 0.98922598885329 1.200781397336464e-07 6.920536048859975 12.954272311303379 up VTDK(ub)LTPIHDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTDKLTPIHDR 11 1 P28072;I3L3X7;A0A087X2I4 P28072 PSMB6 Proteasome subunit beta type-6;Proteasome subunit beta type 1 18263400.0 1091200.0 3348200.0 13824000.0 True False 1412579.9107677254 3161869.7266956544 11308173.846218232 1.0 2.2383652086466417 8.005333900063986 20.429901053565143 -6.9414025293577675 0.6463833126625284 0.9365094904145503 9.626843308289782 0.9983419027399211 0.12430173050528164 0.0871325579454487 0.051739198614121594 0.12232525984590302 0.4933650779837509 1.1444517053821977e-07 6.9414025293577675 8.690333817875231 VTDLLGGLFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTDLLGGLFSK 11 0 O43615;M0QXU7 O43615 TIMM44 Mitochondrial import inner membrane translocase subunit TIM44 0 16081700.0 2903900.0 6513000.0 6664800.0 False True 3807041.0214075986 5541285.7874751575 5975190.429275942 1.0 1.455536138516928 1.569510387641345 21.860238684552026 -11.865217716805429 0.2329319560279534 6.161883357725464e-12 1.6295506671234687 0.9993551745797353 0.00624793169591024 4.849268785916671 0.13742204050810902 2.419628265172876 0.05788289061680296 1.3638992268500852e-12 11.865217716805429 1.6295506671173068 VTDLLGGLFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTDLLGGLFSK 11 0 O43615;M0QXU7 O43615 TIMM44 Mitochondrial import inner membrane translocase subunit TIM44 0 23990700.0 8229100.0 7078100.0 8683500.0 False True 7967871.724881594 9904422.241803877 6409030.8505839165 1.0 1.2430448912568381 0.8043591904937648 22.925762990906016 -6.756337740448751 1.6263799260996583 1.1418191759714373 0.803048309257039 0.6757520909461416 0.10217861240685747 0.2891341871862116 1.5064664784296524 0.0495919386049988 0.11960630423170414 1.7525170810721983e-07 6.756337740448751 -0.3387708667143984 VTDLLGGLFSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTDLLGGLFSK 11 0 O43615;M0QXU7 O43615 TIMM44 Mitochondrial import inner membrane translocase subunit TIM44 0 35117900.0 2903900.0 13417000.0 18797000.0 False True 3977550.304946775 12824192.575914223 14357535.73636684 1.0 3.224143403030028 3.6096427790016254 21.923448746074918 -10.000752077046053 0.41930485788853655 2.0792793628986215e-15 3.6389571154445974 0.9989451862392772 0.037354536729518696 1.3228945115898092 0.1883443108789692 1.750247423110513 0.09301015441655494 9.982697771693127e-11 10.000752077046053 3.638957115444595 VTDLLGGLFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTDLLGGLFSK 11 0 O43615;M0QXU7 O43615 TIMM44 Mitochondrial import inner membrane translocase subunit TIM44 0 15167700.0 8229100.0 3092500.0 3846100.0 False True 6842861.26094212 3075840.088686815 4650301.727642836 1.0 0.4494961933896254 0.6795843946429195 22.706168266340292 -10.28771562300508 5.683672141758334 1.000038954452473 0.5645402940162701 0.8268637635646453 0.09393311481758028 4.637077241022651e-05 5.8113241893765385e-06 0.09095845943710194 0.030316782445487234 5.155661279271884e-11 10.28771562300508 -0.4354986604362029 VTDLNSLELDK(ub)GNFVVDQMCEIGKPEPLNEEEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTDLNSLELDKGNFVVDQMCEIGKPEPLNEEEAR 34 2 O94782 O94782 USP1 Ubiquitin carboxyl-terminal hydrolase 1 1 34541800.0 12521000.0 8396800.0 13624000.0 True False 16208681.325808935 7929510.698619586 11144571.794044942 1.0 0.48921380704755413 0.6875680735544811 23.95026338787997 -10.15391857325774 5.30434720527792 1.0000133836716676 0.5883909403008378 0.851665095452908 0.0809777902082978 1.2817020648603925e-05 2.0446054835210705e-06 0.07840895545915275 0.02613546940736016 7.015868280088025e-11 10.15391857325774 -0.41162244337082976 VTEDLFSSLK(ub)GYGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTEDLFSSLKGYGK 14 1 P55160;P55160-2;F8W050 P55160 NCKAP1L Nck-associated protein 1-like 1 14726800.0 5061500.0 4138700.0 5526600.0 True False 6635675.515635726 3521222.092526242 4954760.446890592 1.0 0.5306501326397203 0.7466851619274673 22.661811909591908 -10.063999038090847 4.831816108616652 1.0000098287938275 0.6386676472797947 0.7885816853561621 0.08819593140469642 1.0306155663136008e-05 1.9964931356092937e-06 0.08539790557203004 0.028465114458607325 8.629804591610081e-11 10.063999038090847 -0.36134218151403275 VTEDLFSSLK(ub)GYGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTEDLFSSLKGYGK 14 1 P55160;P55160-2;F8W050 P55160 NCKAP1L Nck-associated protein 1-like 1 20031600.0 2676000.0 3662600.0 13693000.0 True False 2591051.844768346 5125095.2802066775 10106392.518805286 1.0 1.977997966561294 3.9004979924316614 21.305106452245454 -6.960381254801039 0.4300267152570269 0.9236569979244379 5.0285669715991625 0.999784079530086 0.017704618369613047 0.07956520830711028 0.02063015140737451 0.025069566908187804 0.15962600898035562 1.0955160514327514e-07 6.960381254801039 4.104909973674725 VTEDLFSSLK(ub)GYGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTEDLFSSLKGYGK 14 1 P55160;P55160-2;F8W050 P55160 NCKAP1L Nck-associated protein 1-like 1 39745000.0 4856000.0 10112000.0 24777000.0 True False 7366907.021153187 8307434.594583387 19879815.089855127 1.0 1.1276692607534733 2.698529387268311 22.812627603591565 -6.923035961657087 0.8018907255692369 0.9689846502345674 2.970419101923336 0.994983523514083 0.05470423063088669 0.0964181020617247 0.09659861807534242 0.04790763426199623 0.14794925880792062 1.1938892406405552e-07 6.923035961657087 2.0014344516887688 up VTEDLFSSLK(ub)GYGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTEDLFSSLKGYGK 14 1 P55160;P55160-2;F8W050 P55160 NCKAP1L Nck-associated protein 1-like 1 21007100.0 2676000.0 4685100.0 13646000.0 True False 2225212.5669005304 4659860.436380463 16499315.508024773 1.0 2.094119234132819 7.4147143304185335 21.08551172767973 -6.940427309048366 0.6555756524698908 0.9406890956099873 8.867729543404813 0.9982193427399816 0.1182329388479441 0.0875722135018654 0.053725858863245414 0.1154670132775874 0.45707756295065793 1.1470244909911729e-07 6.940427309048366 7.927040447794826 VTEDLFSSLK(ub)GYGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTEDLFSSLKGYGK 14 1 P55160;P55160-2;F8W050 P55160 NCKAP1L Nck-associated protein 1-like 1 35710500.0 4856000.0 8181500.0 22673000.0 True False 6286187.72607045 7726192.332883498 18546746.644625712 1.0 1.2290743880970936 2.9503965603361713 22.583753925684015 -6.93128148776828 0.7362022323561193 0.9750288609073758 3.31558458196047 0.9967840891960941 0.04936351876449451 0.09197787835651276 0.0744615586014799 0.04532026916821139 0.15466703604507817 1.1714358538273877e-07 6.93128148776828 2.340555721053094 up VTEFLHQSK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTEFLHQSKLK 11 1 Q8WXW3;A0A087WUI6 Q8WXW3 PIBF1 Progesterone-induced-blocking factor 1 1 20775100.0 6414500.0 11943000.0 2417600.0 True False 5333940.960531932 11878660.688500116 2923108.982280579 1.0 2.2269951573133846 0.5480204981475965 22.34677042563049 -6.710789141287627 1.7922891550924418 1.753732556274278 0.5518621906035047 0.46884096364084427 0.5169881791605196 0.37351940733099354 2.3393793720942693 0.22949875594750938 0.5824998579156873 1.9463048224249618e-07 6.710789141287627 -1.2018703656707732 VTEGLTDVILYHQPDDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTEGLTDVILYHQPDDK 17 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 25826700.0 2596700.0 11124000.0 12106000.0 False True 3404298.8464785707 9464342.561012393 10853387.248951873 1.0 2.780115080320393 3.1881417403112797 21.69892625893561 -10.008432161713907 0.3559417606670633 3.3159602805719497e-20 3.267633604344983 0.9988381993986797 0.03238245021871214 1.3720544479000436 0.15923674847795213 1.5442818002050382 0.11814787166478397 9.807715022264791e-11 10.008432161713907 3.267633604344983 VTEGLTDVILYHQPDDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTEGLTDVILYHQPDDK 17 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 27526300.0 9325500.0 3531800.0 14669000.0 False True 9029467.107020626 4942066.158093685 10826748.839432897 1.0 0.5473264478975853 1.1990462683024607 23.106209415862594 -6.719935452597156 1.7598535128708652 0.7245713889837211 1.1980038630087348 0.5120459445070109 0.19048876772636536 0.35545778183597576 2.151514929619618 0.0859517810280594 0.21576255221480875 1.9057439398002317e-07 6.719935452597156 0.47343247402501376 VTEGLTDVILYHQPDDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTEGLTDVILYHQPDDK 17 0 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 0 23577600.0 2596700.0 9707900.0 11273000.0 False True 3556770.1631789324 9278972.878267702 8610549.574722746 1.0 2.608819927227021 2.4208900715212085 21.762136320458502 -9.979814812661969 6.053465815470953 0.999998989118396 2.5148549993742946 0.9885889281580409 0.07672204231965891 1.0466269831205023e-06 1.7646138865430414e-07 0.07428584673791641 0.024761932682494433 1.0475751489310558e-10 9.979814812661969 1.5148560102558986 VTEGLTDVILYHQPDDKKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTEGLTDVILYHQPDDKKK 19 2 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 13354000.0 3582200.0 5922500.0 3849300.0 True False 4696298.890074141 5038886.0857241815 3451011.3610928883 1.0 1.0729483373330677 0.7348363981659622 22.163092799217118 -6.8502347558825205 1.2339537552030964 1.038935147989895 0.7212580964583083 0.9406508342742579 0.03539231651941096 0.15719478096017034 0.46047404525833113 0.022442463275907206 0.0519411527436635 1.411774210283936e-07 6.8502347558825205 -0.31767705153158665 VTEGLTDVILYHQPDDKKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTEGLTDVILYHQPDDKKK 19 2 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 68614000.0 12033000.0 21153000.0 35428000.0 True False 18254940.730135165 17378081.880856648 28425640.27135599 1.0 0.951965943782496 1.5571477712020771 24.12178364887155 -6.88770055218412 1.035913499335296 0.9656676905413261 1.6069086021525545 0.9793843278956883 0.03943678370183466 0.12102766139102135 0.23291682763298338 0.029091467732100387 0.07194876314508726 1.2950885024704098e-07 6.88770055218412 0.6412409116112284 VTEGLTDVILYHQPDDKKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTEGLTDVILYHQPDDKKK 19 2 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 19807700.0 3582200.0 8045000.0 8180500.0 True False 4906636.145315037 7689545.298742628 6248434.38268601 1.0 1.5671725131044765 1.2734660157452578 22.22630286074001 -10.14112420716361 4.718127240228138 0.9999640027928467 1.4203192644258136 0.7319520846974022 0.11990517546082749 4.700476865045938e-05 8.556266668142352e-06 0.11610795993008237 0.03869922897139699 7.225631227559791e-11 10.14112420716361 0.4203552616329669 VTEGLTDVILYHQPDDKKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTEGLTDVILYHQPDDKKK 19 2 O60506;O60506-2;O60506-3;O60506-4;B7Z645;O60506-5 O60506 SYNCRIP Heterogeneous nuclear ribonucleoprotein Q 1 15660500.0 6184800.0 7201200.0 2274500.0 True False 5142935.233096561 7162405.706273718 2750087.4339002203 1.0 1.39266885186132 0.5347311037872807 22.294160554731683 -6.782260194871057 1.526930123547769 1.2216934802649673 0.5274341069112086 0.7753075457689307 0.1662233743721655 0.24710273167506813 1.138060498862438 0.08572580988983951 0.2019095730424231 1.6509723699262192e-07 6.782260194871057 -0.6942593733537586 VTEGLVDVILYHQPDDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTEGLVDVILYHQPDDK 17 0 O43390;O43390-3;B4DT28 O43390 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 19798700.0 3362900.0 8483400.0 7952400.0 False True 4408794.466369925 7217709.788034207 7129561.932807278 1.0 1.637116414269378 1.617122772946491 22.071952790832036 -10.281463691560793 5.068590957898673 0.9998569842940752 1.6271195936081355 0.9992382480343159 0.008162369890915422 1.3194300490984305e-05 1.8704759627593574e-06 0.00790496069542035 0.002634393554324773 5.230416923505855e-11 10.281463691560793 0.6272626093140603 VTEGLVDVILYHQPDDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTEGLVDVILYHQPDDK 17 0 O43390;O43390-3;B4DT28 O43390 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 34843300.0 14589000.0 6465300.0 13789000.0 False True 14125880.18061486 9046928.006094104 10177247.23886702 1.0 0.6404505694809253 0.720468183839857 23.751837428563846 -9.970680384722662 5.63993613932924 1.000000500298477 0.6804593766601096 0.9550819438258169 0.03266705427003271 2.0550948973412856e-07 3.7438712977990894e-08 0.031629788776196 0.010543246429645105 1.0698419305146638e-10 9.970680384722662 -0.3195411236383675 VTEGLVDVILYHQPDDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTEGLVDVILYHQPDDK 17 0 O43390;O43390-3;B4DT28 O43390 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 41283400.0 3791700.0 31018000.0 6473700.0 False True 5752286.11040086 25482595.555259883 5194170.357476488 1.0 4.429994451976951 0.9029749664372173 22.45570400445309 -6.652533299908009 1.9992651469053597 3.2212710929149893 0.9177488278976681 0.2043984064558262 1.4630565478413828 0.5024104322213763 3.8519721069829167 0.5928703578867306 1.620985773182959 2.2257003807331691e-07 6.652533299908009 -2.303522265017321 VTEGLVDVILYHQPDDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTEGLVDVILYHQPDDK 17 0 O43390;O43390-3;B4DT28 O43390 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 21933900.0 3362900.0 9021400.0 9549600.0 False True 4606255.008955378 8622804.718219608 7294181.160185602 1.0 1.871977279038035 1.5835382856581794 22.135162852354927 -9.989399527540272 5.087241822534772 0.9999947420360065 1.7277577823545796 0.8946035229326739 0.11775472597295253 7.022226518271511e-06 1.3953283733429248e-06 0.11401634670203126 0.0380051743826428 1.0247088155739606e-10 9.989399527540272 0.7277630403185731 VTEGLVDVILYHQPDDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTEGLVDVILYHQPDDK 17 0 O43390;O43390-3;B4DT28 O43390 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 20875800.0 14589000.0 3169400.0 3117400.0 False True 12131399.902283937 3152325.81312336 3769233.926770955 1.0 0.2598484790308398 0.3107006575606608 23.532242703998122 -10.114282846285398 7.782489873233482 1.000000091422787 0.2852745682957506 0.996217697981424 0.020760314951162578 3.293134672344543e-08 3.752544476965157e-09 0.0201010910629151 0.006700362838989458 7.686296859110894e-11 10.114282846285398 -0.7147255231270363 VTEGLVDVILYHQPDDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTEGLVDVILYHQPDDK 17 0 O43390;O43390-3;B4DT28 O43390 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 24260700.0 3791700.0 10434000.0 10035000.0 False True 4908430.395581003 9853338.727776868 8208732.967795134 1.0 2.0074316907188297 1.672374324628368 22.22683032654554 -10.053186736081958 4.34749255362524 0.9999374865958035 1.8399030077795098 0.893371471853584 0.13678659732390466 12207018.155112434 4032521.84356118 7287.887738342384 0.046825690427239594 8.847351134183894e-11 10.053186736081958 0.8399655211837063 VTEIQDWSASSPHSAAYVLWDNGAK(ub)NLYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTEIQDWSASSPHSAAYVLWDNGAKNLYR 29 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 53027000.0 16175000.0 16457000.0 20395000.0 True False 15661533.478747351 23028365.92212126 15052937.663115 1.0 1.4703774667640737 0.9611407263242636 23.900722143371222 -6.663946780583225 1.9586806229950866 1.3017842934984714 0.9632373019963429 0.2525882815668189 0.2000881804272907 0.4751648837798771 3.5082810202542722 0.0824107713940317 0.22194577757696365 2.167969756403525e-07 6.663946780583225 -0.3385469915021284 VTEIQDWSASSPHSAAYVLWDNGAK(ub)NLYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTEIQDWSASSPHSAAYVLWDNGAKNLYR 29 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 99771000.0 19383000.0 46182000.0 34206000.0 True False 29405428.087111246 37940461.27838708 27445169.1069776 1.0 1.290253662214727 0.9333368324267706 24.809579157760417 -6.690463437020992 1.8651198683557602 1.181894831787343 0.9345750934142645 0.372463685446203 0.12274569117519626 0.41565820908952195 2.803872640657313 0.05264529359200391 0.13699425112917685 2.03956036168355e-07 6.690463437020992 -0.24731973837307852 VTEIQDWSASSPHSAAYVLWDNGAK(ub)NLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTEIQDWSASSPHSAAYVLWDNGAKNLYR 29 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 40409100.0 16175000.0 14475000.0 9759100.0 True False 13450229.173997015 14397020.301937474 11799682.689019846 1.0 1.0703921930022475 0.8772848801589099 23.6811274188055 -6.808042776144933 1.4225635255071918 1.0384525210070055 0.8740496744194344 0.8547123133776198 0.030414976873077707 0.20947344263578263 0.8358195640721164 0.016812701394619642 0.03893011872614061 1.5558123832070416e-07 6.808042776144933 -0.1644028465875711 VTEIQDWSASSPHSAAYVLWDNGAK(ub)NLYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTEIQDWSASSPHSAAYVLWDNGAKNLYR 29 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 114896000.0 19383000.0 71567000.0 23946000.0 True False 25091675.59605097 67584233.53755087 19588073.706708774 1.0 2.693492241235079 0.7806602485244798 24.580705479852867 -6.673074442816639 1.9267801881536857 2.07808647187265 0.7883276396748102 0.2926556954299915 0.7188536353818255 0.4540652432587678 3.2528449112728586 0.30006565837901555 0.7984109460885369 2.1228805459043587e-07 6.673074442816639 -1.28975883219784 VTELALTASDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTELALTASDR 11 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 9570500.0 3176900.0 4094400.0 2299200.0 False True 4164946.6651433622 3483531.4798462 2061300.8394837414 1.0 0.836392818424313 0.49491650318955266 21.98986659038298 -6.959201988937622 0.4465402249264662 1.011409738044599 0.3064403435623536 0.9997394413102635 0.003396531500911237 0.07998745774583772 0.0221941524854294 0.004541368019748005 0.028260911536449936 1.0984948142722215e-07 6.959201988937622 -0.7049693944822454 down VTELALTASDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTELALTASDR 11 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 8226200.0 3176900.0 2689500.0 2359800.0 False True 4351485.782494376 2570668.997012842 1802463.841606556 1.0 0.5907566117656652 0.41421802384318956 22.053076651905872 -13.999999999999986 0.1146128240921713 2.96100967818677 0.11085601257164329 0.99971973140172 0.004107519612438437 11.987539352158485 0.10345546970369025 5.39665799187484 0.26922783125491456 1.0000000000000327e-14 13.999999999999986 -2.8501536656151267 VTESASVMPSQDVSGSEDTFPNK(ub)RPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTESASVMPSQDVSGSEDTFPNKRPR 26 2 Q9H040 Q9H040 SPRTN SprT-like domain-containing protein Spartan 1 10097300.0 2267000.0 3020000.0 4810300.0 True False 2972058.9536592294 2569427.7718677972 4312576.299655815 1.0 0.8645278616375666 1.4510399581226767 21.503031302733746 -6.845907421068248 1.2546167037712797 0.9278840855464064 1.472706663613923 0.9341426155017761 0.06434386610235072 0.1620183786009075 0.492813324678412 0.04016898080653705 0.09274574754211881 1.425911524003999e-07 6.845907421068248 0.5448225780675165 VTESASVMPSQDVSGSEDTFPNK(ub)RPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTESASVMPSQDVSGSEDTFPNKRPR 26 2 Q9H040 Q9H040 SPRTN SprT-like domain-containing protein Spartan 1 17672800.0 3786800.0 4346600.0 9539400.0 True False 3666590.1067895237 6082220.047219561 7040744.964134308 1.0 1.65882192175148 1.9202432666516964 21.80600756350171 -10.676812388550228 0.190595854000255 7.439781336514985e-20 2.1553006619606867 0.9994346327044995 0.009206357148717918 2.535828340546812 0.10119288532330835 1.3380891021535972 0.17283386353419022 2.104687450135638e-11 10.676812388550228 2.1553006619606867 VTESASVMPSQDVSGSEDTFPNK(ub)RPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTESASVMPSQDVSGSEDTFPNKRPR 26 2 Q9H040 Q9H040 SPRTN SprT-like domain-containing protein Spartan 1 11544700.0 2267000.0 3572800.0 5704900.0 True False 3105171.163371449 3414941.8823303515 4357520.116103593 1.0 1.099759627621483 1.40331076351115 21.566241364256637 -6.951131402152395 0.5462798363535202 0.9957064005580496 1.5215337335768244 0.9992871159513877 0.004579412962070139 0.08303455457740092 0.034106358530200595 0.004994489489738253 0.025164977855820073 1.1190992323844736e-07 6.951131402152395 0.5258273330187748 VTESASVMPSQDVSGSEDTFPNK(ub)RPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTESASVMPSQDVSGSEDTFPNKRPR 26 2 Q9H040 Q9H040 SPRTN SprT-like domain-containing protein Spartan 1 16346800.0 3786800.0 7247300.0 5312700.0 True False 3148891.9836842013 7208257.35642358 6423561.006850598 1.0 2.289140876782291 2.039943268976485 21.586412838935985 -10.47613464832406 6.619147578170112 0.9996031621327414 2.164542072879388 0.9667972509755131 0.10173449737440442 0.0005959601439998761 4.716669762613331e-05 0.09853394440456396 0.03283466783882087 3.3409144251579055e-11 10.47613464832406 1.1649389107466463 VTESASVMPSQDVSGSEDTFPNK(ub)RPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTESASVMPSQDVSGSEDTFPNKRPR 26 2 Q9H040 Q9H040 SPRTN SprT-like domain-containing protein Spartan 1 42774600.0 5814600.0 12456000.0 24504000.0 True False 7527114.322901413 11762812.650295999 20044523.43227223 1.0 1.5627253879361682 2.662975819469929 22.843665452819838 -6.960485319917737 0.4285389301676736 0.9556130479591463 3.3121793914330584 0.9997877780756803 0.010060951125606126 0.07952820960445843 0.020494078019545343 0.014327389578494856 0.09138625349822756 1.0952535766542144e-07 6.960485319917737 2.3565663434739124 VTESVK(ub)NIVPGWLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTESVKNIVPGWLQR 15 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 21991100.0 6473100.0 9404000.0 6114000.0 True False 6267614.983695803 13159066.241212137 4512559.983931607 1.0 2.0995332794760593 0.7199804065294867 22.579485127856234 -6.694411643099821 1.851048714669856 1.6864686368413468 0.724515239080835 0.39107175146521655 0.46461649045370235 0.407220051806362 2.7085956501512896 0.20056144119476085 0.5193310053358499 2.0211025820343263e-07 6.694411643099821 -0.9619533977605118 VTESVK(ub)NIVPGWLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTESVKNIVPGWLQR 15 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 17806700.0 6473100.0 8229000.0 3104600.0 True False 5382669.456952098 8184668.743671383 3753757.5059514707 1.0 1.520559419285965 0.6973784171538209 22.35989040329051 -6.735820032091782 1.702192480645987 1.3112210542932137 0.6973377108992558 0.5859814567593846 0.2187483308588732 0.32541572468839564 1.8496884698816438 0.10173810759553793 0.25079232187153494 1.8372995467924492e-07 6.735820032091782 -0.6138833433939579 VTEVHHEQK(ub)ASNSSASQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTEVHHEQKASNSSASQR 18 1 C9J858;H7C4L7;O76064-3;O76064 C9J858 RNF8 E3 ubiquitin-protein ligase RNF8 1 3757640.0 911640.0 1018800.0 1827200.0 True False 882700.4872065067 1425612.152971814 1348601.505174982 1.0 1.61505762558653 1.5278132557091002 19.75156446845625 -10.611345271770825 6.28649961476241 0.997940843416667 1.5714354406478153 0.9828179557288972 0.0356173648550577 0.0010307116641135499 6.372240057944364e-05 0.03457982180121277 0.011495455076619313 2.4471169671481556e-11 10.611345271770825 0.5734945972311483 VTFLCGDAGPLAVGAVIYHK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTFLCGDAGPLAVGAVIYHKLR 22 1 Q9NS86 Q9NS86 LANCL2 LanC-like protein 2 1 35347100.0 15858400.0 8963700.0 10525000.0 True False 24058352.204336017 7364057.70129225 8444729.136728631 1.0 0.30609152442140375 0.3510102880282318 24.520034497579957 -9.799213864793039 6.494213318969127 1.0000000106869007 0.3285509062246599 0.9966546972473691 0.018338008452804772 2.835019176869473e-09 5.092621482882367e-10 0.017755700731700488 0.005918566778276709 1.5877646742223871e-10 9.799213864793039 -0.6714491044622408 VTFLPTGITFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTFLPTGITFK 11 0 A0A087WY82;Q9Y624 A0A087WY82 F11R Junctional adhesion molecule A 0 16419400.0 5233900.0 4381100.0 6804400.0 False True 6861693.585159707 3727456.9573940467 6100345.960413691 1.0 0.5432269615559188 0.88904377391718 22.71013327186784 -10.34977636124655 6.01504307400566 1.0000348327763011 0.7161353677365496 0.47324025470686804 0.14117912246014827 6.59556924881179e-05 7.1297684954665784e-06 0.13671283901306114 0.04556536584336085 4.469136698766515e-11 10.34977636124655 -0.2838994650397515 VTFLPTGITFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTFLPTGITFK 11 0 A0A087WY82;Q9Y624 A0A087WY82 F11R Junctional adhesion molecule A 0 10396500.0 3557400.0 1518200.0 5320900.0 False True 3444472.284222314 2124425.1773084076 3927196.666421604 1.0 0.6167636148618498 1.1401446556589954 21.71585153882759 -6.710430197190898 1.7937236012617865 0.7644996821986932 1.138928760021457 0.46714588218141306 0.16148250556741206 0.3741988084204131 2.3472004291895927 0.07163604310983303 0.18189078677492596 1.9479141069942588e-07 6.710430197190898 0.3744290778227638 VTFLPTGITFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTFLPTGITFK 11 0 A0A087WY82;Q9Y624 A0A087WY82 F11R Junctional adhesion molecule A 0 13648500.0 5233900.0 3383500.0 5031100.0 False True 7169014.27082922 3234005.7822617404 3842857.798756996 1.0 0.4511088498485681 0.536037124991314 22.77334333339073 -10.747608453823034 6.985637829093516 1.0087377764617578 0.49357298741994104 0.9793430124980201 0.03467182313907059 0.0047066896384822645 0.00017005274872020245 0.03348824093047453 0.011190282800022447 1.788098941848831e-11 10.747608453823034 -0.5151647890418167 VTFLPTGITFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTFLPTGITFK 11 0 A0A087WY82;Q9Y624 A0A087WY82 F11R Junctional adhesion molecule A 0 6318300.0 3557400.0 1347700.0 1413200.0 False True 2958135.719541086 1340439.6726024956 1708693.5861014668 1.0 0.45313663729074827 0.577625149114709 21.496256814261866 -9.916172217936477 6.882531168464954 1.000000016823723 0.5153808932028756 0.9528436276984982 0.05082222213453518 1.3088462421997768e-08 2.1307928758188397e-09 0.049208406452592675 0.01640280166202382 1.212907780809414e-10 9.916172217936477 -0.48461912362084747 VTFNSALAQK(ub)EAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTFNSALAQKEAK 13 1 A0A3B3IU60;A0A3B3ITP9;Q9Y287-2;Q9Y287 A0A3B3IU60 ITM2B Integral membrane protein 2B;BRI2, membrane form;BRI2 intracellular domain;BRI2C, soluble form;Bri23 peptide 1 61891000.0 23621000.0 18619000.0 19651000.0 True False 30967359.746089406 15841117.776293574 17617703.025702424 1.0 0.5115424080767496 0.5689120147844444 24.884245049368168 -10.07996866328047 5.068883437265742 1.0000099772685023 0.5402272114302092 0.9884575886730325 0.023421043868375332 2.640848737607137e-06 4.793441426615026e-07 0.02267781990900546 0.007559109403646948 8.318237895681967e-11 10.07996866328047 -0.45978276583829303 VTFNSALAQK(ub)EAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTFNSALAQKEAK 13 1 A0A3B3IU60;A0A3B3ITP9;Q9Y287-2;Q9Y287 A0A3B3IU60 ITM2B Integral membrane protein 2B;BRI2, membrane form;BRI2 intracellular domain;BRI2C, soluble form;Bri23 peptide 1 41331300.0 16944000.0 15655000.0 8732300.0 True False 16406121.994676685 21906123.139746502 6445048.666615302 1.0 1.3352407806582451 0.39284412664409873 23.967730925596328 -6.810530465018655 1.4123033663813405 1.1825874110082715 0.37615615646705575 0.8612117566425059 0.14530427555848113 0.20607550857799556 0.8100216057012162 0.08089656742102763 0.18708570102072702 1.5469259859170338e-07 6.810530465018655 -0.8064312545412158 down VTFNSALAQK(ub)EAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTFNSALAQKEAK 13 1 A0A3B3IU60;A0A3B3ITP9;Q9Y287-2;Q9Y287 A0A3B3IU60 ITM2B Integral membrane protein 2B;BRI2, membrane form;BRI2 intracellular domain;BRI2C, soluble form;Bri23 peptide 1 53295000.0 23621000.0 12939000.0 16735000.0 True False 32354322.03352317 12367312.196448829 12782537.668143798 1.0 0.3822460623231335 0.3950797564201615 24.94745511089106 -9.979842800328223 5.477847375347188 1.0000015776668052 0.38866290937063425 0.9996695847032442 0.005239333679011776 1.0094684411024866e-07 1.8795385006319426e-08 0.005072976094991813 0.0016909876731531295 1.0475076411911153e-10 9.979842800328223 -0.611338668296171 VTFNSALAQK(ub)EAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTFNSALAQKEAK 13 1 A0A3B3IU60;A0A3B3ITP9;Q9Y287-2;Q9Y287 A0A3B3IU60 ITM2B Integral membrane protein 2B;BRI2, membrane form;BRI2 intracellular domain;BRI2C, soluble form;Bri23 peptide 1 44228500.0 16944000.0 20994000.0 6290500.0 True False 14089686.7464733 20880901.155017275 7605814.466014205 1.0 1.4819989635499768 0.5398143055180391 23.748136201030604 -6.767697650202416 1.5838080549264235 1.2772818588876884 0.5350365702205443 0.7214732017210161 0.20301713291927373 0.2701716979870002 1.3372182709429783 0.10106956773868622 0.24104637979384497 1.7072705534543817e-07 6.767697650202416 -0.7422452886671441 VTFNSALAQK(ub)EAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTFNSALAQKEAK 13 1 A0A3B3IU60;A0A3B3ITP9;Q9Y287-2;Q9Y287 A0A3B3IU60 ITM2B Integral membrane protein 2B;BRI2, membrane form;BRI2 intracellular domain;BRI2C, soluble form;Bri23 peptide 1 45271800.0 28702000.0 12695000.0 3874800.0 True False 37155304.801003724 11988512.09019812 3169626.158805445 1.0 0.32265950055869974 0.08530749985180634 25.147064868615686 -9.719268578430325 0.2951605892031592 1.4181877682328967 5.1127108314176864e-18 0.9987387953458194 0.013763404136390605 1.1264945054220914 0.1279855118309956 0.5127876961654918 0.08460666924957658 1.9086725232924805e-10 9.719268578430325 -1.4181877682328967 VTFNSALAQK(ub)EAK(ub)K(ub)DEPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTFNSALAQKEAKKDEPK 18 3 A0A3B3IU60;A0A3B3ITP9;Q9Y287-2;Q9Y287 A0A3B3IU60 ITM2B Integral membrane protein 2B;BRI2, membrane form;BRI2 intracellular domain;BRI2C, soluble form;Bri23 peptide 3 11568400.0 4087300.0 3314300.0 4166800.0 True False 5358489.881469504 2819819.3590402156 3735659.506767941 1.0 0.5262339616972297 0.697147813917954 22.353395049955683 -10.069656155989819 5.231214685512867 1.0000052765395597 0.6116908878069157 0.8731349485329943 0.06977528798806606 4.293956169173772e-06 7.636393676819929e-07 0.06756054994028986 0.022519877362543617 8.518121766324287e-11 10.069656155989819 -0.388314388732644 VTFVNFTVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTFVNFTVTR 10 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6H2 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 16029300.0 3864700.0 6440200.0 5724400.0 False True 5066659.125808036 5479347.263702986 5132094.000322163 1.0 1.0814517273903115 1.0129147970860761 22.27260333995514 -10.270876820225284 4.337349301277908 0.9999675416791622 1.047183262239002 0.3872266387536134 0.027980084633070383 8.788205351709215e-06 1.4773531549038675e-06 0.027110235170927467 0.009030533483733116 5.3594864809797214e-11 10.270876820225284 0.0472157205598398 VTFVNFTVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTFVNFTVTR 10 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6H2 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 6100100.0 4184500.0 1915600.0 0.0 False True 4051665.3379794974 2680509.0697220345 0.0 1.0 0.6615820523465945 0.0 21.95008358374537 -7.508799614018676 0.7118311079539068 0.9933645288354818 5.331584434516558e-17 0.9870778414545545 0.047208756938428874 0.11931980982904292 0.14272011077486613 0.04176942871399118 0.07571259587741605 3.098848796127714e-08 7.508799614018676 -0.9933645288354818 down VTFVNFTVTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTFVNFTVTR 10 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6H2 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 46404000.0 11190000.0 13512000.0 21702000.0 False True 16976048.098579925 11100678.030262155 17412590.187675472 1.0 0.6539023667817451 1.025715177440624 24.01699731319964 -11.798382707331536 17.05429823681772 0.9022292039768821 0.8558278964215273 0.0 0.17360991064511036 0.0 0.0 0.0 0.05044792278969477 1.5908062649594778e-12 11.798382707331536 -0.046401307555354765 VTFVNFTVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTFVNFTVTR 10 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6H2 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 14881000.0 3864700.0 4158200.0 6858100.0 False True 5293584.029590486 3974476.974671422 5238358.027003105 1.0 0.7508102171335306 0.9895673701827203 22.33581340147803 -10.6374634409799 8.613304471463707 1.0000978755962429 0.8701887936910785 0.28271183457729077 0.09747219956835063 0.00018333811558702103 7.716733891709695e-06 0.09444785618493493 0.03145901713720232 2.3042869433534084e-11 10.6374634409799 -0.12990908190516437 VTFVNFTVTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTFVNFTVTR 10 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y542;A0A2R8Y6H2 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 27618000.0 11190000.0 16428000.0 0.0 False True 14485675.5878765 15513767.358627383 0.0 1.0 1.0709729942876343 0.0 23.788123635292088 -6.976218111702547 1.1593882959199764 1.0471528861428714 1.0272365342718634e-21 0.9789453654959412 0.0709538198782917 0.09818796380380902 0.2603286111676872 0.051291146809481575 0.09553251711419555 1.0562868867823498e-07 6.976218111702547 -1.0471528861428714 down VTGDSQPK(ub)EQGQGDLKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTGDSQPKEQGQGDLKK 17 2 O76094;O76094-2 O76094 SRP72 Signal recognition particle subunit SRP72 1 2508090.0 721450.0 1229300.0 557340.0 True False 945827.9365317383 1045893.2317738697 499671.8031827884 1.0 1.1057965105250132 0.5282903833598295 19.851218229153414 -6.859433280156565 1.188539195255679 1.0573201901840035 0.5006187914761209 0.9529497709667105 0.05445451864861868 0.14739219767835685 0.39595215174067067 0.03574151856013749 0.08338200445080983 1.382186732336117e-07 6.859433280156565 -0.5567013987078826 VTGDSQPK(ub)EQGQGDLKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTGDSQPKEQGQGDLKK 17 2 O76094;O76094-2 O76094 SRP72 Signal recognition particle subunit SRP72 1 4840800.0 2187400.0 1382700.0 1270700.0 True False 2117962.1843222245 1934819.320685246 937865.5498171244 1.0 0.9135287376740456 0.4428150590975984 21.014245399930232 -6.9379282886355425 0.6785630736742942 1.0055207797255914 0.32325832646930686 0.997879764478361 0.011273738508179035 0.08872460920711912 0.059009734881183225 0.010808972006304497 0.04089694815738748 1.1536437335002704e-07 6.9379282886355425 -0.6822624532562845 down VTGDSQPK(ub)EQGQGDLKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTGDSQPKEQGQGDLKK 17 2 O76094;O76094-2 O76094 SRP72 Signal recognition particle subunit SRP72 1 4961800.0 2187400.0 2234900.0 539500.0 True False 1818920.0182504538 2222860.150107085 652306.9556338394 1.0 1.222076907067725 0.3586232209711273 20.794650675364508 -6.838442603864499 1.2894698841490877 1.1181808305089465 0.33106455474304874 0.9217609746407002 0.1024015075100319 0.17062950092337167 0.5517622962857616 0.0622834630784887 0.14344573980380776 1.4506324764795514e-07 6.838442603864499 -0.7871162757658977 down VTGEADVEFATHEDAVAAMAK(ub)DK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTGEADVEFATHEDAVAAMAKDK 23 1 P55795 P55795 HNRNPH2 Heterogeneous nuclear ribonucleoprotein H2 1 36677400.0 3640900.0 7695500.0 25341000.0 True False 5523511.485444117 6322177.899784063 20332340.242645137 1.0 1.14459396281598 3.6810533111456576 22.397154298642715 -6.918629306931804 0.8348432582506915 0.9412212396124601 4.077438832692125 0.9937912962426861 0.09701245008955635 0.0989850343742257 0.1098475509778802 0.0829848980915861 0.2454085029785464 1.2060649407002785e-07 6.918629306931804 3.1362175930796647 up VTGEADVEFATHEDAVAAMAK(ub)DK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTGEADVEFATHEDAVAAMAKDK 23 1 P55795 P55795 HNRNPH2 Heterogeneous nuclear ribonucleoprotein H2 1 44675500.0 3640900.0 6175600.0 34859000.0 True False 4713216.822868595 5831922.431211305 28515019.683544673 1.0 1.2373550062273253 6.050012285704615 22.168280620735164 -6.9171572708640685 0.8455369520071502 0.8825473638127369 6.77753827475215 0.9933542468690991 0.1896737812161226 0.09987353412066698 0.11449293981590865 0.16100940238665246 0.46994125197104636 1.210159819564592e-07 6.9171572708640685 5.894990910939413 up VTGEADVEFATHEDAVAAMSK(ub)DK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTGEADVEFATHEDAVAAMSKDK 23 1 P31943;G8JLB6;E9PCY7;H0YB39;H0YBD7;H0YBG7 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 16731700.0 3137900.0 5111200.0 8482600.0 True False 3038289.0820996216 7152128.814555888 6260752.58745474 1.0 2.3539987872429116 2.060617807680177 21.534827712854153 -10.062937472613974 4.805127653804381 0.9999638105792039 2.207308297475994 0.9575899876258998 0.11977228342563746 41532961.1184627 0.5106324776428293 17435.155963426558 0.04100123836280876 8.650924611743944e-11 10.062937472613974 1.20734448689679 VTGEADVEFATHEEAVAAMSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTGEADVEFATHEEAVAAMSK 21 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 7460800.0 2332400.0 1012300.0 4116100.0 False True 2258359.2386912103 1416516.6690747624 3037969.929646858 1.0 0.6272326584745118 1.3452111061867449 21.10684356413978 -6.765610223008228 1.5913299285289002 0.7849936234109766 1.348589680531014 0.7134629051713188 0.15693969550238787 0.27358740802442855 1.3665841992728969 0.07776978798375729 0.18587440897459195 1.7154962655923057e-07 6.765610223008228 0.5635960571200375 VTGGAASK(ub)LSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTGGAASKLSK 11 1 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 1 18505300.0 3835900.0 6068500.0 8600900.0 True False 3714131.454165499 8491683.696809439 6348066.268530811 1.0 2.2863174881130783 1.7091657489428067 21.824593446772123 -10.686889856840864 10.944455798943622 0.9996265796757068 1.9977416185279424 0.7993858503378687 0.23562121085450877 0.0021474979836353814 6.143764871104773e-05 0.22820441699377395 0.07604641880439487 2.0564120647372823e-11 10.686889856840864 0.9981150388522356 VTGGAASK(ub)LSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTGGAASKLSK 11 1 P42766;F2Z388 P42766 RPL35 60S ribosomal protein L35 1 13185200.0 3835900.0 6501700.0 2847600.0 True False 3189720.8091830066 6466674.051613594 3443019.994185212 1.0 2.0273479838725836 1.0794110833377557 21.6049987222064 -6.627040968650168 2.09074309228047 1.6782626996848085 1.0831415741114234 0.10711641513060388 0.4410026930607327 0.5667315259265516 4.716726451702461 0.1727320667639426 0.4887610103868482 2.3602555707940312e-07 6.627040968650168 -0.595121125573385 VTGSLSSAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTGSLSSAKR 10 1 P39748;P39748-2 P39748 FEN1 Flap endonuclease 1 1 3765590.0 1220600.0 1646400.0 898590.0 True False 1181852.721122659 2303816.105862579 663222.3218778376 1.0 1.9493258886556952 0.5611717179513139 20.172618831790018 -6.722598597912088 1.749809280741616 1.575942880526976 0.5629866307768178 0.5248292396160195 0.399357502257658 0.3502876739425819 2.0973858608890734 0.18111432552850756 0.4533076832611734 1.8940934493473818e-07 6.722598597912088 -1.0129562497501583 VTGSLSSAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTGSLSSAKR 10 1 P39748;P39748-2 P39748 FEN1 Flap endonuclease 1 1 3851350.0 1220600.0 1945100.0 685650.0 True False 1014982.9817484235 1934621.3602278798 829016.2449125902 1.0 1.9060628552562278 0.8167784680335384 19.953024107224294 -6.685922408624049 1.8807977616682028 1.570205189323763 0.8207121304205962 0.3514042206899517 0.3835250575487209 0.42552579850682287 2.9150924916218997 0.16332271695644104 0.4275194862960568 2.0609980998359948e-07 6.685922408624049 -0.7494930589031668 VTGSLSSAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTGSLSSAKR 10 1 P39748;P39748-2 P39748 FEN1 Flap endonuclease 1 1 2275510.0 545660.0 518950.0 1210900.0 True False 706367.6265666398 490069.97630628763 990528.6248832218 1.0 0.6937888400807872 1.402284855122496 19.430059698988856 -6.789240902964823 1.499297271878572 0.8286893593651457 1.4096701564554692 0.7988733859079004 0.13011383035004517 0.23648662600238396 1.0501915588720936 0.06831051103185759 0.16002514885283778 1.6246473145830845e-07 6.789240902964823 0.5809807970903236 VTGVPLSYLLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTGVPLSYLLSR 12 0 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 4399600.0 1062700.0 1726700.0 1610200.0 False True 1393209.991201439 1469083.090623882 1443591.9501290543 1.0 1.0544591984708733 1.0361625018811187 20.40998129347477 -9.959381331151477 5.053019553290117 0.99999975003121 1.045310850176665 0.8910327164899066 0.007469595106227842 2.1036403863516457e-08 4.329648727238191e-09 0.007232444236854703 0.002410801453777938 1.0980412837100789e-10 9.959381331151477 0.04531110014545503 VTGVPLSYLLSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTGVPLSYLLSR 12 0 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y7K6;A0A2R8Y705 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 5591100.0 1062700.0 1902700.0 2625700.0 False True 1455608.9083876654 1818632.4226125055 2005563.737988955 1.0 1.249396326261118 1.3778177135577292 20.473191354997663 -12.677061991190367 0.09576019056952201 2.753023264816093e-17 1.691364835716055 0.9998509079645364 0.0019152651113461287 7.581252746427175 0.07831912370254145 1.7331020923525662 0.2518291532814681 2.1034781678821737e-13 12.677061991190367 1.691364835716055 VTHAVVTVPAYFNDAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTHAVVTVPAYFNDAQR 17 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 372359000.0 208122200.0 12907000.0 151329800.0 False True 272850219.65825176 10981325.91109195 135671643.9539433 1.0 0.04024671823554401 0.49723853667361423 28.02353396425253 -10.199767640943449 5.207630210621957 1.0000497457575794 0.2687426274542797 0.7734476697048703 0.18656612863436003 0.0001077605999738203 1.6558761406192754e-05 0.18065410240432125 0.06021395909712172 6.312950137026928e-11 10.199767640943449 -0.7313071183032998 VTHAVVTVPAYFNDAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTHAVVTVPAYFNDAQR 17 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 543696200.0 146673700.0 83550500.0 313472000.0 False True 142017623.6786242 116912650.36010167 231364279.24157822 1.0 0.8232263527001881 1.6291237189346242 27.08149473119571 -6.849230516066105 1.2389290945894398 0.9057310401003913 1.660841489415449 0.9391585985008792 0.08530777642922659 0.1583081656001159 0.46801144321709 0.053892562483152176 0.12464108273877877 1.4150425002897353e-07 6.849230516066105 0.7551104493150578 VTHAVVTVPAYFNDAQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTHAVVTVPAYFNDAQR 17 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 712191000.0 119916000.0 462405000.0 129870000.0 False True 181921339.03389758 379885214.9632447 104201137.57595694 1.0 2.088183920482579 0.5727812807959876 27.43873953745255 -6.713971414227795 1.780868549582992 1.6662595922777403 0.5758822320120265 0.4839899051733838 0.45828172820953444 0.36716581771404816 2.2722418761137293 0.20459224516631266 0.51730771592057 1.9320954856228013e-07 6.713971414227795 -1.0903773602657139 VTHAVVTVPAYFNDAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTHAVVTVPAYFNDAQR 17 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 728170200.0 208122200.0 240083000.0 279965000.0 False True 285070601.63097715 229475339.2116877 213843033.06016594 1.0 0.8049772158152692 0.7501406031933976 28.08674402577542 -13.999999999904592 0.1779784698798904 2.0057260036204636 0.7056597132919208 0.9995007131382622 0.002395858476805056 12.179217304426048 0.13371683801167825 4.233972097680973 0.04165725798782254 1.0000000002196853e-14 13.999999999904592 -1.3000662903285427 VTHAVVTVPAYFNDAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTHAVVTVPAYFNDAQR 17 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 333740400.0 146673700.0 117649800.0 69416900.0 False True 121965680.29663597 117015997.17574318 83931652.84251836 1.0 0.9594174106285102 0.6881579526173753 26.861900006629988 -6.933595073364388 0.7166662156534216 1.0036258546233805 0.6270029833930172 0.9971988606548301 0.007326691657206211 0.09081365168643538 0.06884672936727518 0.006823916902326494 0.02407756427720136 1.1652119411116297e-07 6.933595073364388 -0.3766228712303633 VTHAVVTVPAYFNDAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTHAVVTVPAYFNDAQR 17 0 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 414268900.0 119916000.0 182652900.0 111700000.0 False True 155233625.8977481 172488105.5501967 91371746.13878584 1.0 1.1111516886413133 0.5886079488922852 27.209865859544998 -6.851101458273343 1.2298020676704682 1.059372871769146 0.5672746860236226 0.9418913628290534 0.05417984056590472 0.1562460538425831 0.45418929945836267 0.03446422919211885 0.07980854172373304 1.4089596040303064e-07 6.851101458273343 -0.49209818574552333 VTHELQAMK(ub)DK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VTHELQAMKDK 11 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 78726600.0 23386100.0 32223800.0 23116700.0 True False 30659403.571314577 27416134.647388626 20724805.635044273 1.0 0.894216176893917 0.6759689759403776 24.869826296202483 -6.959432296215638 0.4433619663479609 1.0075356227230514 0.5540927105600393 0.9997485599858027 0.00213931819830152 0.07990453162723853 0.02188532971945039 0.002889922925599743 0.018072055918272555 1.0979124345919291e-07 6.959432296215638 -0.45344291216301214 VTHELQAMK(ub)DK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VTHELQAMKDK 11 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 86609700.0 25860700.0 40508800.0 20240200.0 True False 25039766.233931527 56684175.0906013 14938684.427015467 1.0 2.2637661454597873 0.5965983982219439 24.57771775784301 -6.703999604257559 1.8166167592465174 1.7816489742637196 0.601168184600181 0.43659027388530147 0.5330705491398381 0.3872511397331902 2.4872242751931433 0.23386060824231564 0.5984739322373942 1.976971441588002e-07 6.703999604257559 -1.1804807896635388 VTHELQAMK(ub)DK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTHELQAMKDK 11 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 81318000.0 26644000.0 31054000.0 23620000.0 True False 40420895.937315784 25512171.073990554 18951496.646986242 1.0 0.6311629290343912 0.46885394812564235 25.268597963910317 -13.999999999999998 0.1114387999667879 2.7754065044833465 0.17717796159405316 0.9997357612885323 0.0036125414708946912 12.004363488032231 0.10153162986021112 4.782750890369011 0.2589837775636439 1.0000000000000041e-14 13.999999999999998 -2.5982285428892933 VTHELQAMK(ub)DK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VTHELQAMKDK 11 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 65841200.0 23386100.0 24431700.0 18023400.0 True False 32032573.155589364 23352226.70917222 13766644.123574711 1.0 0.729015012179797 0.4297701610391099 24.933036357725374 -6.969847917955394 0.26179465338736735 1.0821936250506632 0.0676925611456049 0.9999811710769989 0.0010105496814782912 0.07635208332592656 0.009206642233036267 0.0061751434316023035 0.02815891096932508 1.0718945975554065e-07 6.969847917955394 -1.0145010639050582 down VTHELQAMK(ub)DK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTHELQAMKDK 11 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 60254500.0 17589000.0 33266000.0 9399500.0 True False 14626032.824818151 33086789.455215953 11364891.991622398 1.0 2.2621848215103624 0.7770317575342718 23.802035169155896 -6.681605752514349 1.8968702189716662 1.797470999488177 0.7826998028643254 0.3312421568461529 0.534760371311381 0.43492937355297084 3.0271900665642133 0.22613553921140114 0.5950430827845183 2.0815854687745871e-07 6.681605752514349 -1.0147711966238515 VTHELQAMK(ub)DK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTHELQAMKDK 11 1 E9PMD8;E9PLG2;P17980;R4GNH3;E9PKD5;E9PN50 E9PMD8;P17980 PSMC3 26S protease regulatory subunit 6A 1 89497000.0 26644000.0 45741000.0 17112000.0 True False 34491183.231758855 43195473.1404295 13997791.583947232 1.0 1.252362751668545 0.4058368044346568 25.039724286002766 -6.826804860538213 1.3420226151490133 1.1351758429386174 0.38449295362390223 0.8993469427509264 0.11258203361249607 0.18479097742126957 0.6519931174631766 0.06588567377646826 0.1516644429056848 1.4900304355669297e-07 6.826804860538213 -0.7506828893147152 down VTIAK(ub)AGIHAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTIAKAGIHAR 11 1 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 1 6124600.0 1425600.0 2130600.0 2568400.0 True False 1380345.108333988 2981359.6909322194 1895658.98965161 1.0 2.1598654372243047 1.3733224960963433 20.396597578238552 -10.141164848365852 4.839664648124465 0.9999465330827593 1.7665939666642612 0.5588021350030364 0.32110481110549227 224427692.33146173 15.388875058944675 133721.07634177245 0.10992271772664565 7.224955085880676e-11 10.141164848365852 0.7666474335815019 VTIAK(ub)AGIHAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTIAKAGIHAR 11 1 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 1 10656400.0 2410300.0 2301600.0 5944500.0 True False 3656601.316533262 1890861.4975171222 4769566.969433094 1.0 0.5171090129425988 1.304371616305988 21.802071905870722 -6.740723052559203 1.6839286146904744 0.712922742390164 1.3049166934666379 0.608219576541658 0.20288770239206871 0.3165176876280537 1.7625452612914414 0.09530214517987312 0.23368843394449093 1.8166737773448802e-07 6.740723052559203 0.5919939510764739 VTIAK(ub)AGIHAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTIAKAGIHAR 11 1 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 1 4612600.0 1968800.0 1599500.0 1044300.0 True False 2696718.5648194584 1528828.8011608254 797657.8480336157 1.0 0.566921895783062 0.295788317861422 21.36277353608665 -8.525068130401753 0.20634782787752598 1.3078994267604116 2.778510424278139e-10 0.9996670950329543 0.005291539212857318 0.16926442403168035 0.05338458998525736 0.15275742757721547 0.12469321551184775 2.984914320625915e-09 8.525068130401753 -1.3078994264825605 down VTIAK(ub)AGIHAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTIAKAGIHAR 11 1 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 1 6487100.0 1425600.0 3915600.0 1145900.0 True False 1185449.5647882642 3894505.8856142554 1385502.3919570278 1.0 3.2852564978670027 1.1687569282666999 20.17700285367283 -6.628032233162733 2.087602873740104 2.5077681210382936 1.177245203513146 0.11032454956371118 0.9807559132781816 0.56426701348157 4.683641183705378 0.3845877311867547 1.0865865159801809 2.35487449956645e-07 6.628032233162733 -1.3305229175251476 VTIAK(ub)AGIHAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTIAKAGIHAR 11 1 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 1 8606600.0 2410300.0 2348200.0 3848100.0 True False 3120180.8641160624 2217520.6057663057 3147785.2848403044 1.0 0.7107025849908616 1.00884705788748 21.57319822796317 -10.987969118209413 10.805776609193053 1.103949637858074 0.8597748214391708 0.22776488130160288 0.121716971371294 0.06971732804059395 7.76214938470181e-05 0.026955410080459978 0.039283983589318866 1.0280894008577296e-11 10.987969118209413 -0.24417481641890315 VTIAQGGVLPNIQAVLLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTIAQGGVLPNIQAVLLPK 19 0 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 0 5555800000.0 3460300000.0 1578500000.0 517000000.0 False True 4536486809.592863 1342993952.944807 463505799.4141854 1.0 0.2960427329150191 0.10217285288564164 32.0789283179219 -11.596606796815484 0.23019788427301643 2.3714175069017065 8.875830041609158e-14 0.99930382748454 0.01017807155054862 4.289750338840312 0.13532499324649092 2.99863768659184 0.0991983612025759 2.5315890188259647e-12 11.596606796815484 -2.3714175069016177 VTIAQGGVLPNIQAVLLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTIAQGGVLPNIQAVLLPK 19 0 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 0 18827177550.0 8667782600.0 5434318700.0 4725076250.0 False True 8392628585.867323 7604270496.507667 3487437030.875961 1.0 0.906065414274712 0.41553572819230833 32.96647559002252 -6.938840948712023 0.6702614748828967 1.0056318850217305 0.28764788269986574 0.9980080858040613 0.011437286891773327 0.08829945874712902 0.05704800726705872 0.011037883326784459 0.042439071925205324 1.1512219227478707e-07 6.938840948712023 -0.7179840023218648 down VTIAQGGVLPNIQAVLLPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTIAQGGVLPNIQAVLLPK 19 0 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 0 8343286400.0 1662009500.0 4556138000.0 2125138900.0 False True 2521389920.6699533 3743059576.6313252 1705104264.933533 1.0 1.4845223049185365 0.6762556838017633 31.231572095196544 -6.744372299959795 1.6707830040032114 1.2868213991910638 0.6753244514394312 0.6243631855310187 0.20356747813521217 0.3099637610153797 1.7005520087062562 0.09632636700821233 0.2352427220869767 1.801472761999564e-07 6.744372299959795 -0.6114969477516325 VTIAQGGVLPNIQAVLLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTIAQGGVLPNIQAVLLPK 19 0 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 0 10321700000.0 3460300000.0 1409000000.0 5452400000.0 False True 4739666421.091392 1346745721.0600824 4164655415.70286 1.0 0.2841435665318342 0.8786811234584468 32.14213837944479 -10.397251051799088 8.31705314037811 1.0000040615460661 0.581412344995429 0.39792629600671625 0.24271894123185123 1.8279955771314512e-05 1.3246681125318994e-06 0.23501388265147222 0.07833720143333808 4.006350563178656e-11 10.397251051799088 -0.4185917165506371 VTIAQGGVLPNIQAVLLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTIAQGGVLPNIQAVLLPK 19 0 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 0 14579582600.0 8667782600.0 2520700000.0 3391100000.0 False True 7207645279.776436 2507120488.7802267 4100163331.325145 1.0 0.3478418250985281 0.5688630852616434 32.746880865456795 -10.10480763048134 5.150903233974313 1.0000132637860457 0.45835245517922163 0.8889830505354491 0.09023155162094465 1.3744217522410146e-05 2.388800000693443e-06 0.08736845963421981 0.029122108060406823 7.855835295686391e-11 10.10480763048134 -0.5416608086068241 VTIAQGGVLPNIQAVLLPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTIAQGGVLPNIQAVLLPK 19 0 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 0 5288109800.0 1662009500.0 2271412000.0 1354688300.0 False True 2151504060.8551235 2145005925.468384 1108148929.675771 1.0 0.9969797243217116 0.515057791355194 31.002698417288993 -6.908274857480591 0.907403711938648 1.0157475236090123 0.4550222904045702 0.9902540772242796 0.022498161325578813 0.10556985773169841 0.14503755901234844 0.018263855167977343 0.04983370612001213 1.2351654711207464e-07 6.908274857480591 -0.5607252332044421 VTIAQGGVLPNIQAVLLPK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTIAQGGVLPNIQAVLLPKK 20 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 1 21909604700.0 4200734400.0 14929797700.0 2779072600.0 True False 5507203478.369801 12702330079.05561 2491520826.098757 1.0 2.3064936912074394 0.4524112529861122 32.35867276768875 -6.717342965967092 1.768766138891375 1.7970916496711609 0.4557005503043928 0.5000119763524591 0.5499631543372231 0.3604992884833834 2.2026623815430186 0.24701773422229586 0.6220789748618581 1.9171541501173582e-07 6.717342965967092 -1.341391099366768 VTIAQGGVLPNIQAVLLPK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTIAQGGVLPNIQAVLLPKK 20 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 1 22204225900.0 14056089600.0 470266000.0 7677870300.0 True False 13609886729.562418 658045666.2047935 5666805737.258261 1.0 0.048350561564589216 0.41637420280282217 33.66393600870755 -10.617493558145346 6.474729577754644 1.0025617130240028 0.23236238218370586 0.85296191379753 0.15024502238579465 0.005566292102849951 0.0003288383848176327 0.1457463477062375 0.0484913724625619 2.4127173199655794e-11 10.617493558145346 -0.7701993308402969 VTIAQGGVLPNIQAVLLPK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTIAQGGVLPNIQAVLLPKK 20 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 1 54034597800.0 2718128400.0 33220506000.0 18095963400.0 True False 4123599504.6037636 27292047151.301994 14519288302.24746 1.0 6.618500928820071 3.521022903906527 31.94125707496106 -9.408329898433458 9.904251471287148 1.0000257558839027 5.069761916363275 0.6971313421652744 1.2645401085077876 0.0 0.0 1.2243856951759813 0.40812856505866035 3.905441182711429e-10 9.408329898433458 4.069736160479372 VTIAQGGVLPNIQAVLLPK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTIAQGGVLPNIQAVLLPKK 20 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 1 32813313510.0 4200734400.0 21764956010.0 6847623100.0 True False 5753859428.258685 20803308286.393467 5230355555.004582 1.0 3.615539890360036 0.9090169164225597 32.42188282921164 -6.653940231018573 1.9941410262339032 2.6919034827120965 0.9203198636549126 0.21025089391610152 1.1152664108537795 0.49899318744807436 3.8077086865203205 0.45284014676609996 1.2358602961012375 2.2185017160209974e-07 6.653940231018573 -1.7715836190571839 VTIAQGGVLPNIQAVLLPK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTIAQGGVLPNIQAVLLPKK 20 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 1 35356439500.0 14056089600.0 16644924200.0 4655425700.0 True False 11688261292.750275 16555254689.575905 5628853689.613585 1.0 1.4164001193098255 0.48158178095358983 33.44434128414183 -6.78561824957509 1.513853291080686 1.2340570513904723 0.4728121856437172 0.7868046442011268 0.17656345257095807 0.24194202866988151 1.0954083871100018 0.09182900215347148 0.21569493671625695 1.6382559367025792e-07 6.78561824957509 -0.7612448657467551 down VTIAQGGVLPNIQAVLLPK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTIAQGGVLPNIQAVLLPKK 20 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 1 34838788900.0 2718128400.0 31785582200.0 335078300.0 True False 3518670796.1209855 30016686608.797607 274097487.5936973 1.0 8.530689100522922 0.0778980198704195 31.71238339705351 -6.671780728033645 1.9312109813878087 5.7997278021219 0.11215449243174734 0.286700742583623 3.1976312888318232 0.45717610548516496 3.2889476452428097 1.332214470923664 3.550903820303507 2.129213798424579e-07 6.671780728033645 -5.687573309690153 VTIAQGGVLPNIQAVLLPK(ub)KTESHHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTIAQGGVLPNIQAVLLPKKTESHHK 26 2 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q93077;Q7L7L0;P04908 A0A0U1RR32;Q93077 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;HIST1H2AC;HIST3H2A;HIST1H2AB Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E 1 2316876000.0 881800000.0 582109000.0 852967000.0 True False 1337755068.215173 478227100.91162455 684377698.581283 1.0 0.3574847984315044 0.5115866983739981 30.317166848726355 -10.289605233196506 8.518927040444531 1.0000005018847047 0.4345357484041034 0.9472374467396683 0.06291183720875632 5.996824353398008e-07 5.007856074997805e-08 0.06091417799506417 0.02030470814906878 5.133277788047517e-11 10.289605233196506 -0.5654647534806012 VTIAQGGVLPNIQAVLLPK(ub)KTESHHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTIAQGGVLPNIQAVLLPKKTESHHK 26 2 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q93077;Q7L7L0;P04908 A0A0U1RR32;Q93077 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;HIST1H2AC;HIST3H2A;HIST1H2AB Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E 1 727398000.0 121920000.0 601707000.0 3771000.0 True False 166997118.76411432 575121595.1610358 2880367.4661828657 1.0 3.443901304509348 0.017248006956643507 27.315247970896536 -6.715213086304689 1.7765403857885622 2.494405956087213 0.02397588361816976 0.48980934815651345 1.029054014171988 0.36471674836147705 2.2468706378826826 0.46040710376673377 1.1623520584132696 1.9265794063228121e-07 6.715213086304689 -2.470430072469043 VTIAQGGVLPNIQAVLLPK(ub)KTESHHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTIAQGGVLPNIQAVLLPKKTESHHK 26 2 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q93077;Q7L7L0;P04908 A0A0U1RR32;Q93077 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;HIST1H2AC;HIST3H2A;HIST1H2AB Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E 1 116550600.0 11739000.0 103368800.0 1442800.0 True False 9761498.62587643 102811931.75729968 1744482.8092465324 1.0 10.53239217641838 0.17871055215048037 23.21867122266022 -6.664741666870667 1.956282481563879 7.112188165742793 0.2219689169240481 0.2556596465278209 4.054216028118503 0.4734513616481415 3.4880078286291467 1.6715472662805375 4.496363561302402 2.1640053649551956e-07 6.664741666870667 -6.890219248818744 VTIAQGGVLPNIQAVLLPK(ub)KTESHHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTIAQGGVLPNIQAVLLPKKTESHHK 26 2 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q93077;Q7L7L0;P04908 A0A0U1RR32;Q93077 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;HIST1H2AC;HIST3H2A;HIST1H2AB Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E 1 2036670000.0 881800000.0 698910000.0 455960000.0 True False 1141507482.8766313 660015044.1087332 372979958.54468113 1.0 0.5781959855799426 0.3267433320758976 30.088293170818805 -8.836437673138631 0.17971073981303043 1.4079306899592559 1.644081502479043e-09 0.9997403055274311 0.00447632230474053 0.34782816488462787 0.054185570201710775 0.22572763839759025 0.14588964132714405 1.457344837510108e-09 8.836437673138631 -1.4079306883151743 down VTIAQGGVLPNIQAVLLPKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTIAQGGVLPNIQAVLLPKK 20 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 1 163670690.0 45247540.0 53811430.0 64611720.0 True False 59319963.117800616 45782974.399311215 57926319.01378244 1.0 0.7717970813365653 0.976506322142335 25.822014365008418 -10.316845140880757 7.119377968438926 1.000001722700199 0.8741517017934284 0.3350694438599727 0.08357219760111075 2.2851390072391425e-06 2.193346130269981e-07 0.08091953923246871 0.026972810792921433 4.821196794300167e-11 10.316845140880757 -0.12585002090677055 VTIAQGGVLPNIQAVLLPKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTIAQGGVLPNIQAVLLPKK 20 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 1 11166530900.0 12792900.0 11124105700.0 29632300.0 True False 12386796.391979413 15566019117.454842 21870711.680055037 1.0 1256.662225233153 1.765647144585065 23.562299774448192 -9.446980502628874 8.455843716568278 2.0983923406054252 199.99999999999997 0.0 620.7074252691201 0.0 0.0 722.7683782190245 240.92280984815017 3.572888780460004e-10 9.446980502628874 197.90160765939456 VTIAQGGVLPNIQAVLLPKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTIAQGGVLPNIQAVLLPKK 20 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 1 141824100.0 67161100.0 56446000.0 18217000.0 True False 101888298.83409628 46372770.28538907 14616401.965205241 1.0 0.4551334237201997 0.1434551575839438 26.602413136575834 -8.590217526966537 0.3080270631855462 1.1799661825956864 5.635845276954655e-22 0.9986125978588042 0.013184848157095752 0.21386481503975763 0.08971563624515361 0.13303952365958321 0.09535895322533346 2.5691086598210563e-09 8.590217526966537 -1.1799661825956864 VTIAQGGVLPNIQAVLLPKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTIAQGGVLPNIQAVLLPKK 20 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 1 151554840.0 45247540.0 66751800.0 39555500.0 True False 61976778.306791365 63802484.757316194 30213305.571094204 1.0 1.0294579115017466 0.48749396784607396 25.88522442653131 -6.894055397883023 0.9981157784701575 1.0263530151177924 0.437007023971859 0.9833685163053687 0.03209011462512228 0.11591319573678682 0.2031357460991791 0.0243579807508064 0.06167990323968664 1.2762759987803585e-07 6.894055397883023 -0.5893459911459334 down VTIAQGGVLPNIQAVLLPKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTIAQGGVLPNIQAVLLPKK 20 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 1 159937650.0 12792900.0 131840200.0 15304550.0 True False 10637863.171562685 131129950.67436916 18504660.64475605 1.0 12.32671905622061 1.7395091802104599 23.34270504988247 -6.630249794211418 2.079604206070335 8.46102947535671 1.7822988156293498 0.11830421696236848 4.858296031574456 0.5584171181254801 4.602589078552618 1.9105355312147536 5.381633822703072 2.342880867229986e-07 6.630249794211418 -6.678730659727361 VTIAQGGVLPNIQAVLLPKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTIAQGGVLPNIQAVLLPKK 20 1 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q9BTM1;H0YFX9;Q93077;Q7L7L0;P04908;Q16777 A0A0U1RR32;Q93077;Q16777 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;H2AFJ;HIST1H2AC;HIST3H2A;HIST1H2AB;HIST2H2AC Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A.J;Histone H2A;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E;Histone H2A type 2-C 1 140007100.0 67161100.0 58903700.0 13942300.0 True False 86941367.89320228 55625657.31448633 11404944.460078754 1.0 0.6398065577115858 0.1311797218797897 26.373539458668283 -7.4841436065450235 0.49082017986854765 1.0154618008252008 6.923039426939725e-16 0.9974394501405334 0.01803530127382031 0.11537497295351917 0.06608247809559749 0.020885572722942017 0.06756891582421717 3.2798682099486024e-08 7.4841436065450235 -1.0154618008252 down VTIAQGGVLPNIQAVLLPKKTESHHK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTIAQGGVLPNIQAVLLPKKTESHHK 26 2 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q93077;Q7L7L0;P04908 A0A0U1RR32;Q93077 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;HIST1H2AC;HIST3H2A;HIST1H2AB Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E 1 219227900.0 151915000.0 19337600.0 47975300.0 True False 199162036.14695263 16452505.457374426 43011276.167573236 1.0 0.08260864256898272 0.21596121931509663 27.56936742918416 -10.668522299606414 6.535616880206226 1.0057992638932738 0.14928493094215936 0.9819047248800448 0.054440961485552095 0.0045965819675109305 0.0002331322393826786 0.05266951916905007 0.017570744765421878 2.1452489614442347e-11 10.668522299606414 -0.8565143329511145 VTIAQGGVLPNIQAVLLPKKTESHHK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTIAQGGVLPNIQAVLLPKKTESHHK 26 2 A0A0U1RR32;A0A0U1RRH7;Q99878;Q96KK5;Q6FI13;P20671;P0C0S8;Q93077;Q7L7L0;P04908 A0A0U1RR32;Q93077 HIST1H2AJ;HIST1H2AH;HIST2H2AA3;HIST1H2AD;HIST1H2AG;HIST1H2AC;HIST3H2A;HIST1H2AB Histone H2A type 1-J;Histone H2A type 1-H;Histone H2A type 2-A;Histone H2A type 1-D;Histone H2A type 1;Histone H2A type 1-C;Histone H2A type 3;Histone H2A type 1-B/E 1 474977100.0 151915000.0 297741000.0 25321100.0 True False 208082080.84851053 284585818.1221793 19340777.684423998 1.0 1.3676613428782731 0.09294782907570313 27.632577490707053 -6.8295303566521985 1.3298182074005755 1.196510138528418 0.05891345002696685 0.9050052404067329 0.16511063769376738 0.18135832454201384 0.6273753752410485 0.09748898245601505 0.22437596672365717 1.4807087519225406e-07 6.8295303566521985 -1.1375966885014512 down VTIAQGGVLPNIQAVLLPKKTESHK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTIAQGGVLPNIQAVLLPKKTESHK 25 2 Q16777 Q16777 HIST2H2AC Histone H2A type 2-C 1 44363700.0 10109200.0 11835000.0 22419500.0 True False 13253259.097632067 10069264.132468682 20099745.20302965 1.0 0.7597575855336396 1.5165888673089347 23.659843839421413 -6.821351004893689 1.36614483832417 0.8706842803529182 1.5335767150559498 0.887425836625118 0.10594607343756264 0.19173996059018147 0.7028127758035758 0.060937423223564276 0.14039411910112712 1.5088601723144797e-07 6.821351004893689 0.6628924347030316 VTIAQGGVLPNIQAVLLPKKTESHK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTIAQGGVLPNIQAVLLPKKTESHK 25 2 Q16777 Q16777 HIST2H2AC Histone H2A type 2-C 1 303377000.0 134450000.0 55807000.0 113120000.0 True False 203970479.61162412 45847804.82791884 90761782.41774268 1.0 0.2247766682473693 0.4449750894862839 27.60378512698348 -10.216265382293747 5.083177736168307 1.0000690302148054 0.33487587887099013 0.9240416022428328 0.08989562903510147 50240738.96166972 100974823.37261133 28013.98219980637 0.030773658820639076 6.077635045894256e-11 10.216265382293747 -0.6651931513438153 VTIAQGGVLPNIQAVLLPKKTESHK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTIAQGGVLPNIQAVLLPKKTESHK 25 2 Q16777 Q16777 HIST2H2AC Histone H2A type 2-C 1 260384000.0 134450000.0 69146000.0 56788000.0 True False 174048175.40571922 65297964.31578097 46453166.694085784 1.0 0.3751717831201997 0.26689832620077747 27.37491144907593 -13.999999999999998 0.2465824637555416 5.2716528978765815 0.22192576258901212 0.9995363839290751 0.006957012051808016 13.865097071324618 0.15713962009311447 29.27684439236662 0.05093515567565448 1.0000000000000041e-14 13.999999999999998 -5.0497271352875694 VTIEYYSQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTIEYYSQLK 10 0 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 20937200.0 5286400.0 7333900.0 8316900.0 False True 6930521.593570429 6239710.707318288 7456346.969338178 1.0 0.9003233916920454 1.0758709670936697 22.724532503525044 -6.752655569420689 1.6398167698831152 0.9415776047831177 1.0762961677077296 0.6604042886057511 0.04189163588316419 0.2954332102246608 1.563763581800159 0.020173130698963156 0.04884299570657521 1.7674389867735744e-07 6.752655569420689 0.13471856292461193 VTIEYYSQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTIEYYSQLK 10 0 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 16058500.0 5422300.0 2045600.0 8590600.0 False True 5250172.054516954 2862418.747663078 6340464.147524185 1.0 0.545204750994858 1.2076678786306068 22.323933271746945 -6.721960947083465 1.7523678614232048 0.7238835745845784 1.2067416363865549 0.5216713939687376 0.19133545192567722 0.351539305066942 2.1107602536487056 0.08666256259698081 0.21704637166949098 1.8968764857280578e-07 6.721960947083465 0.48285806180197643 VTIEYYSQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTIEYYSQLK 10 0 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 45312000.0 10925000.0 21045000.0 13342000.0 False True 16574023.72448488 17289355.32466451 10704947.851993654 1.0 1.0431598030792528 0.6458870839058343 23.982420556611206 -6.879983828676554 1.0798501969040433 1.026746268535946 0.617736925947796 0.9736740765359064 0.02887734253380461 0.12764621367647902 0.2723510605217715 0.02059969280095994 0.04981491414020158 1.318305825878243e-07 6.879983828676554 -0.40900934258815014 VTIEYYSQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTIEYYSQLK 10 0 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 17347700.0 5286400.0 5587800.0 6473500.0 False True 7240924.939588373 5340912.519616416 4944592.625917469 1.0 0.7376008678692411 0.6828675434658705 22.787742565047935 -13.999999999999998 0.22030954564801355 2.585581303366061 0.653677263817617 0.9994982028936115 0.0031005479633777937 13.007938712087913 0.14869004950465706 8.974503604958226 0.030228756344933654 1.0000000000000041e-14 13.999999999999998 -1.931904039548444 VTIEYYSQLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTIEYYSQLK 10 0 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 12035000.0 5422300.0 3894000.0 2718700.0 False True 4508882.698619103 3873022.2491015177 3287167.600151472 1.0 0.8589760497179656 0.7290426076416237 22.10433854718122 -6.972106479740148 0.20161661801960631 1.0757444722533793 0.5086804066996672 0.9999944849719101 0.0002597845080157646 0.07562490068522282 0.00652292136680323 0.004162921638749581 0.013738135739416209 1.066334646675265e-07 6.972106479740148 -0.5670640655537121 VTIEYYSQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTIEYYSQLK 10 0 P49189;P49189-3;P49189-2 P49189 ALDH9A1 4-trimethylaminobutyraldehyde dehydrogenase 0 39173000.0 10925000.0 17162000.0 11086000.0 False True 14142627.863945566 16206919.613389546 9068461.751965802 1.0 1.1459623889776929 0.6412147614436238 23.753546878703656 -6.829369361635114 1.3308982267888836 1.0780251591377328 0.627822899188629 0.9045739465045521 0.06551391732631272 0.18159238104928743 0.6293191504699185 0.03865404957844377 0.08894828913158805 1.4812577594088273e-07 6.829369361635114 -0.4502022599491038 VTILCDK(ub)FSGHPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTILCDKFSGHPK 13 1 Q92843-2;Q86U42-2;Q86U42;B4DEH8;G3V4T2;A6NDY0-2;A6NDY0;A6NDY0-4 Q92843-2 PABPN1;PABPN1L Polyadenylate-binding protein 2;Embryonic polyadenylate-binding protein 2 1 11929600.0 5113300.0 4197500.0 2618800.0 True False 6703585.817267641 3571249.3617268475 2347831.6973034185 1.0 0.5327371736672234 0.35023519669960557 22.676501583839784 -13.999999999941886 0.1299947677587118 3.220538749742554 0.09463674872109518 0.999645639996003 0.00515083773124289 11.936744182388198 0.1121214701529287 6.77252578185774 0.22731121147588154 1.0000000001338113e-14 13.999999999941886 -3.125902001021459 VTILCDK(ub)FSGHPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTILCDKFSGHPK 13 1 Q92843-2;Q86U42-2;Q86U42;B4DEH8;G3V4T2;A6NDY0-2;A6NDY0;A6NDY0-4 Q92843-2 PABPN1;PABPN1L Polyadenylate-binding protein 2;Embryonic polyadenylate-binding protein 2 1 32463000.0 5308000.0 7350000.0 19805000.0 True False 8052624.066779482 6038335.074187894 15890533.069160135 1.0 0.7498593035155594 1.9733360128799977 22.94102755270608 -6.853436916319594 1.2183616224749652 0.8660140189837942 2.0255954193056676 0.945164449270368 0.12358731704522537 0.15371447186148482 0.4373555172101422 0.07929828139105019 0.18395375463488514 1.401403131728119e-07 6.853436916319594 1.1595814003218734 VTILCDK(ub)FSGHPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTILCDKFSGHPK 13 1 Q92843-2;Q86U42-2;Q86U42;B4DEH8;G3V4T2;A6NDY0-2;A6NDY0;A6NDY0-4 Q92843-2 PABPN1;PABPN1L Polyadenylate-binding protein 2;Embryonic polyadenylate-binding protein 2 1 12863300.0 5113300.0 3345200.0 4404800.0 True False 7003825.191736761 3197398.0029029064 3364476.9597036066 1.0 0.4565216742809707 0.48037706076289244 22.739711645362675 -10.266966368989985 5.571042140264446 1.0000438312030107 0.4684493675219291 0.9984916938288808 0.009738920749650251 5.302351952215476e-06 6.976806806754616e-07 0.009430444068111414 0.003143223156111707 5.407961996421014e-11 10.266966368989985 -0.5315944636810815 VTILCDK(ub)FSGHPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTILCDKFSGHPK 13 1 Q92843-2;Q86U42-2;Q86U42;B4DEH8;G3V4T2;A6NDY0-2;A6NDY0;A6NDY0-4 Q92843-2 PABPN1;PABPN1L Polyadenylate-binding protein 2;Embryonic polyadenylate-binding protein 2 1 9753300.0 4816000.0 1746000.0 3191300.0 True False 4004717.3849749444 1736593.9514461358 3858586.0750959674 1.0 0.4336370796005623 0.9635102066310002 21.93326900379797 -10.660807141868354 9.72587431276171 1.0001514377396001 0.6985736431157816 0.30142071703771056 0.21631979827291759 0.0007106803323577353 2.4785453261089493e-05 0.20955356293874555 0.06981691468049649 2.183699416894939e-11 10.660807141868354 -0.3015777946238185 VTILCDK(ub)FSGHPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTILCDKFSGHPK 13 1 Q92843-2;Q86U42-2;Q86U42;B4DEH8;G3V4T2;A6NDY0-2;A6NDY0;A6NDY0-4 Q92843-2 PABPN1;PABPN1L Polyadenylate-binding protein 2;Embryonic polyadenylate-binding protein 2 1 25188500.0 5308000.0 6949500.0 12931000.0 True False 6871310.636322485 6562754.215898524 10577690.68326446 1.0 0.9550949685213038 1.5393992853924625 22.712153874798528 -6.888350835639124 1.0321090870502796 0.96735207553589 1.5880569609422857 0.9798208256685623 0.03771421181752669 0.12049060064325645 0.22975540644310727 0.027901134153925908 0.06915628326790269 1.2931507748048762e-07 6.888350835639124 0.6207048854063957 VTILELFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTILELFR 8 0 P11166 P11166 SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 0 5841800.0 1588600.0 1858900.0 2394300.0 False True 2082669.984024286 1581559.3659354476 2146560.8037473583 1.0 0.7593902913410429 1.0306773613741806 20.99000282006542 -6.672629076248079 1.927667171637948 0.8467744004471607 1.029604611602627 0.2909587330004655 0.10214309512420476 0.4550801028036167 3.262499473718005 0.042616602374841564 0.11348796804046 2.1250586646955399e-07 6.672629076248079 0.18283021115546627 VTILELFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTILELFR 8 0 P11166 P11166 SLC2A1 Solute carrier family 2, facilitated glucose transporter member 1 0 5966800.0 1588600.0 1675900.0 2702300.0 False True 2175948.350300789 1601853.1965398116 2064072.3956154762 1.0 0.7361632440946413 0.9485851974979793 21.053212881588312 -9.946718085901411 5.881231464441556 1.0000001007007353 0.8423742210975307 0.42335402668239863 0.08672089933413592 1.1453289043499056e-07 2.042363496257147e-08 0.0839672035240243 0.0279890499074031 1.1305295385349878e-10 9.946718085901411 -0.15762587960320462 VTIMGIYSIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTIMGIYSIK 10 0 P33992;B1AHB1;B1AHB2 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 30173700.0 6385700.0 10938000.0 12850000.0 False True 8371714.539206763 9306093.03599006 11520405.265903836 1.0 1.1116113661553289 1.3761106177176723 22.997091688384103 -6.956597164081753 0.48099858311713284 0.9937105552696998 1.505057736066627 0.9996224340337853 0.003064631828613596 0.0809398343326326 0.025798552424803303 0.0037369510416043555 0.021818220547775782 1.1051031985689626e-07 6.956597164081753 0.5113471807969273 VTIMGIYSIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTIMGIYSIK 10 0 P33992;B1AHB1;B1AHB2 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 21678400.0 8891800.0 3758200.0 9028400.0 False True 8609534.676125249 5258868.858754091 6663591.193805718 1.0 0.6108191739255371 0.7739780887675907 23.03750383498488 -10.164013999932934 5.301704665496647 1.0000113720140256 0.6923986313464432 0.8257559132945975 0.06660934805863003 8.953751020377126e-06 1.41192401525609e-06 0.06449660658182048 0.021498074644339626 6.854661293850786e-11 10.164013999932934 -0.3076127406675824 VTIMGIYSIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTIMGIYSIK 10 0 P33992;B1AHB1;B1AHB2 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 34760800.0 6313800.0 12361000.0 16086000.0 False True 9578496.200608935 10155082.973066188 12906595.049255747 1.0 1.0601959598230668 1.3474552559132649 23.19136774363428 -6.94085149400695 0.6515960998201711 0.9968169693452106 1.4268991042372041 0.9982732894853823 0.006299898182110224 0.0873803452754236 0.05285717419205985 0.006172782587834584 0.02463255306533316 1.1459047139239644e-07 6.94085149400695 0.43008213489199354 VTIMGIYSIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTIMGIYSIK 10 0 P33992;B1AHB1;B1AHB2 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 31322200.0 6385700.0 9227500.0 15709000.0 False True 8746665.857053839 8819798.538738044 11998857.737010514 1.0 1.0083612067591705 1.3718207523994885 23.060301749906994 -6.911858364754554 0.8829981720928557 0.989396653220228 1.420705468206665 0.9916035807733846 0.015883562890300126 0.10320245411756256 0.13220250211065204 0.013124670634574367 0.03671326310265874 1.2250156450546043e-07 6.911858364754554 0.43130881498643714 VTIMGIYSIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTIMGIYSIK 10 0 P33992;B1AHB1;B1AHB2 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 17308400.0 8891800.0 2854700.0 5561900.0 False True 7393925.673529943 2839321.1644864134 6724867.574679993 1.0 0.3840072635097087 0.9095124662606279 22.817909110419155 -10.290208236358586 8.135817259572967 1.0000005933814442 0.6467598648851818 0.3759576056202687 0.21453660065292846 2.3089758934854375e-06 2.0164305947043432e-07 0.20772451702183997 0.06924139012339527 5.1261553516727616e-11 10.290208236358586 -0.3532407284962624 VTIMGIYSIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTIMGIYSIK 10 0 P33992;B1AHB1;B1AHB2 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 34037800.0 6313800.0 14352000.0 13372000.0 False True 8173338.563604531 13553298.583578074 10938433.208306583 1.0 1.6582328601839935 1.3383066323735664 22.96249406572673 -9.990655567423225 4.323910584312126 0.9999792210196261 1.4982697460706336 0.7638283783803279 0.13060933608122036 90642037.86595653 311374225.4268519 34950.32375754615 0.04779812916423009 1.0217494969839345e-10 9.990655567423225 0.49829052505100746 VTIMPK(ub)DIQLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTIMPKDIQLAR 12 1 Q71DI3;Q16695;P68431;Q6NXT2;K7EK07;P84243 Q71DI3;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 1 15447900.0 3629300.0 7153100.0 4665500.0 True False 4758047.446191193 6085885.36256542 4182758.81463613 1.0 1.2790720209057937 0.8790914470565904 22.18193822739312 -6.719145080444935 1.7628214822990358 1.1699422235842598 0.8797626255427003 0.5083106139068843 0.11744689752262909 0.35696824688161616 2.1675471248217026 0.052915277390153816 0.13294931340463625 1.9092153594076381e-07 6.719145080444935 -0.29017959804155946 VTIMPK(ub)DIQLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTIMPKDIQLAR 12 1 Q71DI3;Q16695;P68431;Q6NXT2;K7EK07;P84243 Q71DI3;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 1 31872100.0 6494100.0 8582000.0 16796000.0 True False 6287948.350190623 12008837.354538785 12396623.730800664 1.0 1.9098180655658106 1.9714894335009692 22.58415793653426 -11.027846297453399 0.4757513960134107 2.709430096417442e-20 1.9703016674981784 0.999737385349367 0.0071975018344830844 2.8697661691024683 0.23141512985206922 3.142077408311291 0.01314730172129669 9.378938812128531e-12 11.027846297453399 1.9703016674981784 VTIMPK(ub)DIQLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTIMPKDIQLAR 12 1 Q71DI3;Q16695;P68431;Q6NXT2;K7EK07;P84243 Q71DI3;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 1 20557100.0 3629300.0 8772700.0 8155100.0 True False 4971150.288144681 8385093.106560527 6229033.339556584 1.0 1.6867510778254884 1.253036616980125 22.24514828891601 -10.416976470258964 5.153878012261722 0.9995353054207602 1.4698938474028258 0.6101452738742621 0.17706318718964273 0.0009463411366440009 0.00010705308015522539 0.1716049619609448 0.05714689793431472 3.828454850288845e-11 10.416976470258964 0.4703585419820656 VTIMPK(ub)DIQLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTIMPKDIQLAR 12 1 Q71DI3;Q16695;P68431;Q6NXT2;K7EK07;P84243 Q71DI3;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 1 23011400.0 6494100.0 14531000.0 1986300.0 True False 5400131.887409838 14452718.618822327 2401626.1463864613 1.0 2.676364007426964 0.4447347206437205 22.364563211968537 -6.7057167522456735 1.8104822985939788 2.035096845632143 0.4506303306410966 0.44466757956938485 0.7069073798293694 0.3837882814437865 2.4494820051715127 0.3110382965966705 0.7943121711797516 1.9691701678208778e-07 6.7057167522456735 -1.5844665149910466 VTIMPK(ub)DIQLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTIMPKDIQLAR 12 1 Q71DI3;Q16695;P68431;Q6NXT2;K7EK07;P84243 Q71DI3;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 1 12976900.0 2555100.0 5755600.0 4666200.0 True False 3307627.3185507846 5435295.800420983 3816999.4792551696 1.0 1.6432612495178032 1.1539992603905458 21.657365259707674 -10.088211647788556 4.666298307217288 0.9999799332831261 1.3986302549606053 0.4695264323699332 0.1997403706831949 4.60846433582318e-05 9.00482193496454e-06 0.19340852947454149 0.0644659274304025 8.161845174727965e-11 10.088211647788556 0.39865032167747927 VTIMWTPPESAVTGYR ddPTM_RPMI8226_Bortezomib_1h_R1 2 VTIMWTPPESAVTGYR 16 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 31746500.0 6747800.0 12736400.0 12262300.0 False True 8846431.145788152 10836178.766098365 10993514.824287342 1.0 1.2249209412834854 1.2427061990440553 23.076664125457736 -12.607305770475984 0.3808180041044765 1.9834205924665879e-13 1.2443343021628728 0.9997524250558404 0.0017380196522325854 8.44326685555501 0.19859680147936462 6.6896150707515805 0.004808537475686813 2.4699845091148106e-13 12.607305770475984 1.2443343021626745 VTIMWTPPESAVTGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTIMWTPPESAVTGYR 16 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 24302400.0 9807400.0 6375600.0 8119400.0 False True 9496069.455299353 8921410.328314766 5992685.563221182 1.0 0.9394845278154643 0.6310701065772975 23.178899056373233 -6.939380239729071 0.6653077460383593 1.0035016131047536 0.5493962410027029 0.9980815380976287 0.007076006687243045 0.08805063609607676 0.05590656067825291 0.006856013429552889 0.026617945137965383 1.1497932646450097e-07 6.939380239729071 -0.4541053721020507 VTIMWTPPESAVTGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VTIMWTPPESAVTGYR 16 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 40429800.0 6747800.0 13397200.0 20284800.0 False True 9242644.012438402 12805267.405384073 15493948.018569648 1.0 1.3854550048829348 1.6763545147598975 23.139874186980627 -6.974235887950199 0.11951731667466012 0.47271467454709026 2.5965667340032588 0.9999994567213851 0.00020410163189737456 0.0749505831772836 0.0035577643142994226 0.020607098092221637 0.042045189648192954 1.0611190516301715e-07 6.974235887950199 2.1238520594561683 VTIMWTPPESAVTGYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTIMWTPPESAVTGYR 16 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 18687600.0 9807400.0 5387900.0 3492300.0 False True 8155287.641487391 5358874.313285585 4222523.783429208 1.0 0.6571042676685054 0.5177651566755883 22.95930433180751 -13.999999999999998 0.12394125076060251 2.6307097969490703 0.3067384767467544 0.9996738425496137 0.0036595234297676156 11.95039944754578 0.10883605905410673 4.776788676032568 0.18735580402976537 1.0000000000000041e-14 13.999999999999998 -2.323971320202316 VTINTAIGHINR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTINTAIGHINR 12 0 Q9UPY3-2;Q9UPY3 Q9UPY3-2 DICER1 Endoribonuclease Dicer 0 5836300.0 1762100.0 1668000.0 2406200.0 False True 2310130.1642006733 1419140.9018130768 2157229.505900216 1.0 0.6143120953983616 0.9338129683470184 21.139542711855672 -9.999902629263982 6.827820500323242 1.0000000335353567 0.7740625318726895 0.40003449067348407 0.13043568518300308 6.662079272368769e-08 9.646910607425987e-09 0.1262938279354408 0.04209793637207674 1.0002242295409353e-10 9.999902629263982 -0.22593750166266724 VTINTAIGHINR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTINTAIGHINR 12 0 Q9UPY3-2;Q9UPY3 Q9UPY3-2 DICER1 Endoribonuclease Dicer 0 2699110.0 707950.0 343760.0 1647400.0 False True 685476.514762238 481025.16068471747 1215896.5190593612 1.0 0.7017383532848885 1.7737974866740733 19.386747712846176 -6.832464373065247 1.316793324845656 0.8408794072216553 1.8041400804734702 0.9107281769795902 0.13498778358418154 0.17778798547905128 0.6020174522466112 0.08046603375212383 0.18518049010874232 1.470739061135982e-07 6.832464373065247 0.9632606732518149 VTINTAIGHINR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTINTAIGHINR 12 0 Q9UPY3-2;Q9UPY3 Q9UPY3-2 DICER1 Endoribonuclease Dicer 0 4338500.0 1762100.0 1259900.0 1316500.0 False True 2413595.988961989 1204233.4520678495 1005569.814168588 1.0 0.4989374599457103 0.4166272312215151 21.202752773378563 -13.999999999999998 0.254174768323832 4.559308630989455 0.3848214716138407 0.9995506912364925 0.005464626875565585 14.167404165420304 0.15953011202712902 25.810407571722536 0.037123994862213495 1.0000000000000041e-14 13.999999999999998 -4.174487159375614 VTIQK(ub)TDNQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTIQKTDNQAR 11 1 P56937-3;P56937-2;P56937 P56937-3 HSD17B7 3-keto-steroid reductase 1 4047080.0 635080.0 1430700.0 1981300.0 True False 614919.7330252166 2001985.971001935 1462338.0922740763 1.0 3.255686658733129 2.3780958940442862 19.230038578670776 -10.401536045144995 6.031212818708963 0.9995534549409262 2.816891276388707 0.8510785904082183 0.3582749294110966 0.0021516827225831242 0.00021350594295346855 0.34696999601718775 0.11563273624773428 3.967016025170006e-11 10.401536045144995 1.8173378214477809 VTIQK(ub)TDNQAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTIQKTDNQAR 11 1 P56937-3;P56937-2;P56937 P56937-3 HSD17B7 3-keto-steroid reductase 1 2829290.0 635080.0 1419700.0 774510.0 True False 528097.1588143451 1412051.7943116124 936456.4600703716 1.0 2.6738484968975667 1.773265476702909 19.010443854105052 -9.743348715622972 6.163628382604907 0.9999999780333423 2.2235569868027536 0.711079419407977 0.36766147842422986 1.1106464023500712e-07 2.237642962832418e-08 0.35598670104538427 0.11866223191360181 1.8057236426627096e-10 9.743348715622972 1.2235570087694114 VTIQK(ub)TDNQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTIQKTDNQAR 11 1 P56937-3;P56937-2;P56937 P56937-3 HSD17B7 3-keto-steroid reductase 1 4491820.0 992120.0 1298200.0 2201500.0 True False 1284318.8976089403 1225954.028790485 1800849.5892975568 1.0 0.9545557813350601 1.4021825830409091 20.292572038821838 -6.881889371610866 1.0692470536114322 0.9710676175866138 1.435072461915851 0.9751760484759139 0.031693899478267486 0.12596776324902265 0.2623066452134326 0.022793870572320876 0.05539381996202968 1.3125341999553244e-07 6.881889371610866 0.4640048443292373 VTISFMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTISFMK 7 0 P53041;H0YDU8;A8MU39 P53041 PPP5C Serine/threonine-protein phosphatase 5;Serine/threonine-protein phosphatase 0 14384300.0 4403300.0 4306600.0 5674400.0 False True 5772768.941617851 3664072.0669953227 5087267.520688307 1.0 0.6347165639317006 0.8812525795052124 22.46083205113043 -9.94422785625873 5.238298333820909 1.0000007134993656 0.7579845717166074 0.5623411189479592 0.10064790690211985 8.387231329620572e-07 1.688263079580307e-07 0.09745220433107303 0.03248397227094782 1.1370305766317e-10 9.94422785625873 -0.2420161417827582 VTISFMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTISFMK 7 0 P53041;H0YDU8;A8MU39 P53041 PPP5C Serine/threonine-protein phosphatase 5;Serine/threonine-protein phosphatase 0 11241800.0 3968800.0 1542000.0 5731000.0 False True 3842812.616411282 2157728.6414237707 4229879.17368532 1.0 0.5614972304943731 1.1007248065182815 21.873731198609306 -6.690413382513969 1.8647173537746895 0.7251988227265637 1.0988829459598517 0.3724816341333841 0.1854393849427141 0.41577142127722994 2.803238819852207 0.07954218599781541 0.20704304944807497 2.0397954442739582e-07 6.690413382513969 0.37368412323328803 VTISFMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTISFMK 7 0 P53041;H0YDU8;A8MU39 P53041 PPP5C Serine/threonine-protein phosphatase 5;Serine/threonine-protein phosphatase 0 14999300.0 4403300.0 4343200.0 6252800.0 False True 6031319.004708198 4151303.062958235 4776017.420458298 1.0 0.6882910785713082 0.7918694761013337 22.524042112653323 -10.77076335009832 10.08392216083139 1.001268337113962 0.740080277336321 0.8935731325820692 0.04228570372061933 0.0012105921252422436 2.752019781937226e-05 0.0411071312187731 0.01364765219105163 1.6952613077784953e-11 10.77076335009832 -0.2611880597776409 VTISFMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTISFMK 7 0 P53041;H0YDU8;A8MU39 P53041 PPP5C Serine/threonine-protein phosphatase 5;Serine/threonine-protein phosphatase 0 8189800.0 3968800.0 1889300.0 2331700.0 False True 3300233.0476512737 1879121.965903314 2819247.6894373004 1.0 0.5693906881032711 0.8542571535800227 21.654136474043582 -9.935072999295892 5.304529974923202 1.0000005469247357 0.7118239208427567 0.5770767058351322 0.1162962475477775 8.895403562348627e-07 1.7856257489943093e-07 0.11260361001218949 0.037534452497321145 1.1612534057284949e-10 9.935072999295892 -0.288176626081979 VTK(ub)QYLPHVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTKQYLPHVAR 11 1 Q5T8U5;O15260;O15260-2;O15260-3 Q5T8U5 SURF4 Surfeit locus protein 4 1 6652990.0 574390.0 884500.0 5194100.0 True False 753030.8524006726 752536.0477539967 4656664.357325373 1.0 0.9993429158379122 6.18389584235475 19.522349449152895 -6.906862725143126 0.9168159243598216 0.8231178501650046 6.81086540076857 0.98968327298337 0.2482267068475216 0.10652988183280371 0.1502839891786303 0.20012534862135964 0.5411475045987816 1.239188215966662e-07 6.906862725143126 5.987747550603565 up VTK(ub)SPGETSKPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTKSPGETSKPR 12 2 Q9UNZ2;Q9UNZ2-5;Q9UNZ2-4;Q9UNZ2-6;F2Z2K0 Q9UNZ2 NSFL1C NSFL1 cofactor p47 1 2412080.0 565280.0 1485100.0 361700.0 True False 741087.5541793066 1263528.8688744607 324274.75367139425 1.0 1.7049657112022543 0.4375660498448147 19.499284471108886 -6.75571931768107 1.6284231069481847 1.4116525695028868 0.43386457412836427 0.6733152074854556 0.29635750842892716 0.2901683372378704 1.5154503018754104 0.14365843098798242 0.3467308686095752 1.7550143922807626e-07 6.75571931768107 -0.9777879953745225 VTLATLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTLATLK 7 0 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 0 91842200.0 8906200.0 43973000.0 38963000.0 False True 11676114.44776348 37412399.80541154 34931482.51948718 1.0 3.2041823478852383 2.9917043615633783 23.477056921343834 -9.919046356912919 6.381977384061854 0.9999997352416077 3.0979433547244435 0.9923656274996846 0.08674377467758802 3.272986552493853e-07 5.53016410247391e-08 0.08398930868914666 0.027996432892717544 1.2049073208124356e-10 9.919046356912919 2.0979436194828356 VTLATLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTLATLK 7 0 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 0 43126000.0 19646000.0 5877000.0 17603000.0 False True 19022348.483676694 8223716.748150129 12992246.221319607 1.0 0.4323186884735604 0.6829990646248758 24.18119203536251 -10.367100143796332 5.913561157154777 1.0000799954545705 0.5576588765492239 0.8058845378739018 0.10233983501661445 0.00010795413064708663 1.155383041993495e-05 0.0991079202477169 0.03303003972274659 4.294373915453317e-11 10.367100143796332 -0.44242111890534663 VTLATLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTLATLK 7 0 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 0 166880300.0 5121800.0 155830000.0 5928500.0 False True 7770145.053736089 128020918.994653 4756729.376446138 1.0 16.47600116977188 0.6121802544933158 22.889510100563644 -6.58642023096719 2.2420507151635105 9.999999999999922 0.655665074077993 0.24745434587932003 6.4095336808607275 0.5226455072740884 4.9486102063891755 2.502939345896936 7.486751329907375 2.5916704026648834e-07 6.58642023096719 -9.34433492592193 VTLATLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTLATLK 7 0 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 0 81145200.0 8906200.0 23399000.0 48840000.0 False True 12199062.821005195 22365154.809854437 37304997.891373985 1.0 1.8333502448519698 3.0580216233610704 23.540266982866726 -6.965595519678704 0.3476799541999129 0.8784459522305491 4.0541040059048425 0.9999249004421319 0.007324773437149486 0.07775944007075049 0.014150624602785147 0.01691232236843624 0.10542786417465597 1.0824416143667182e-07 6.965595519678704 3.1756580536742933 VTLATLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTLATLK 7 0 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 0 29343400.0 19646000.0 5715400.0 3982000.0 False True 16336519.46536911 5684610.005781919 4814617.78931223 1.0 0.34796946912911353 0.29471502785636033 23.961597310796787 -13.999999999999998 0.35497895538742336 9.269222863508917 0.2878351691854332 0.9997640795692427 0.004925241753197331 21.16587025033614 0.19216294263444042 132.2886034269909 0.015624429396209718 1.0000000000000041e-14 13.999999999999998 -8.981387694323484 VTLATLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTLATLK 7 0 P06748-2;P06748;P06748-3;E5RI98 P06748-2 NPM1 Nucleophosmin 0 19638700.0 5121800.0 8445600.0 6071300.0 False True 6630271.065771761 7975594.935720932 4966385.6967986645 1.0 1.2029063150817916 0.7490471577304327 22.660636422656093 -6.7851467380507025 1.5154888129235389 1.1141222628381833 0.7448326140183148 0.7852863722213822 0.08601712952273911 0.24265613191919858 1.100972252693923 0.044687647110136904 0.10501444970002687 1.640035549532854e-07 6.7851467380507025 -0.3692896488198685 VTLAVSDLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTLAVSDLQK 10 0 Q9HC38-2;I3L3Q4;F6TLX2;Q9HC38;Q9HC38-3 Q9HC38-2 GLOD4 Glyoxalase domain-containing protein 4 0 15797200.0 3699400.0 5845700.0 6252100.0 False True 4849949.225040563 4973544.346360128 5605192.666377994 1.0 1.0254837969604786 1.155721927445769 22.20953821287845 -6.9393176896808955 0.6658758495579915 0.9985195336814476 1.1901496889738146 0.9980732247288374 0.0029936207667773883 0.08807912755237184 0.05603642449679028 0.0028992284246117327 0.011243438839617212 1.1499588776254142e-07 6.9393176896808955 0.19163015529236693 VTLAVSDLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTLAVSDLQK 10 0 Q9HC38-2;I3L3Q4;F6TLX2;Q9HC38;Q9HC38-3 Q9HC38-2 GLOD4 Glyoxalase domain-containing protein 4 0 9043400.0 2094000.0 1642200.0 5307200.0 False True 2027527.11619765 2297939.023959868 3917085.1074127937 1.0 1.1333703039539804 1.9319520198372249 20.9512897785348 -6.935878474261711 0.6968532874081947 0.9900860026656046 2.123478231889937 0.9975726741020332 0.020274170158103077 0.08969815828911237 0.06355559482614728 0.019166061927995033 0.07007049948793512 1.1591016544917777e-07 6.935878474261711 1.1333922292243324 VTLEVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTLEVGK 7 0 O60869;O60869-2;O60869-3 O60869 EDF1 Endothelial differentiation-related factor 1 0 14740900.0 5262000.0 3911300.0 5567600.0 False True 6898532.957280481 3327749.2861279855 4991518.160190365 1.0 0.4823850674824986 0.7235622691231016 22.717858160158848 -10.38521489917391 5.977723727134358 1.0000839080883521 0.6029736683028013 0.783235753553224 0.09846018026863547 0.00011012678210229193 1.132622685068671e-05 0.09535367915727225 0.03177788653708363 4.11893653948034e-11 10.38521489917391 -0.3971102397855508 VTLEVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTLEVGK 7 0 O60869;O60869-2;O60869-3 O60869 EDF1 Endothelial differentiation-related factor 1 0 9407500.0 3014700.0 1737800.0 4655000.0 False True 2918999.998663353 2431712.602507281 3435715.852993397 1.0 0.8330635846594016 1.1770181070800463 21.477042779503726 -6.774732036972404 1.5563517507451936 0.9048294957980899 1.179307947329585 0.7483226161079384 0.07045465151064587 0.2588471884660594 1.2379711571693284 0.03566902652318793 0.08454357362573 1.6798401727076892e-07 6.774732036972404 0.2744784515314952 VTLEVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTLEVGK 7 0 O60869;O60869-2;O60869-3 O60869 EDF1 Endothelial differentiation-related factor 1 0 21538500.0 2594100.0 15321000.0 3623400.0 False True 3935439.35411316 12586847.84648064 2907233.401807366 1.0 3.198333582075247 0.7387315977233506 21.90809327713243 -6.670967519582718 1.933499583401945 2.401918996942597 0.7484825558171964 0.28368367501095004 0.9335758413800662 0.45879534616459366 3.307477044173762 0.3885494567909942 1.0369665119303912 2.1332044472474723e-07 6.670967519582718 -1.6534364411254008 VTLEVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTLEVGK 7 0 O60869;O60869-2;O60869-3 O60869 EDF1 Endothelial differentiation-related factor 1 0 15422900.0 5262000.0 3501700.0 6659200.0 False True 7207503.600203154 3346983.3154266123 5086434.110529018 1.0 0.464374837819335 0.7057137106925134 22.78106822168174 -10.362541606097516 5.906271680631526 1.0000712851884532 0.585044274255926 0.7976420232841246 0.09852618227295258 9.249964610943472e-05 9.983548033001615e-06 0.09541386288931808 0.031799188592378215 4.339686867673836e-11 10.362541606097516 -0.41502701093252725 VTLEVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTLEVGK 7 0 O60869;O60869-2;O60869-3 O60869 EDF1 Endothelial differentiation-related factor 1 0 6571100.0 3014700.0 2261200.0 1295200.0 False True 2506856.6238546446 2249018.4667869424 1566020.3316718237 1.0 0.8971468273796849 0.6246948137240682 21.257448054938003 -6.95420998217784 0.5105387269995088 1.0049921217636197 0.5048856721871289 0.9994915879101786 0.0035703940839955585 0.08183800895585859 0.02929738806576247 0.004108581244847179 0.022486932012313866 1.1111943328802725e-07 6.95420998217784 -0.5001064495764909 VTLEVGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTLEVGK 7 0 O60869;O60869-2;O60869-3 O60869 EDF1 Endothelial differentiation-related factor 1 0 8877200.0 2594100.0 3939600.0 2343500.0 False True 3358113.5873557194 3720357.796813278 1917007.0463405969 1.0 1.1078713390820114 0.5708583097244505 21.67921959922488 -6.854452374683818 1.2134179682079922 1.057862751848533 0.5474742522042813 0.9465394717426827 0.0536289878517312 0.15262352229288337 0.4302069109268864 0.03454036176039178 0.08018989019305268 1.3981302277549912e-07 6.854452374683818 -0.5103884996442518 VTLILELLQHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTLILELLQHK 11 0 Q9H583;Q5T3Q7 Q9H583 HEATR1 HEAT repeat-containing protein 1;HEAT repeat-containing protein 1, N-terminally processed 0 48843000.0 7704000.0 19631000.0 21508000.0 False True 11687531.237842714 16127694.67229693 17256934.37270871 1.0 1.3799060164286483 1.4765251977965193 23.478466885179344 -12.242960164508878 0.22069907668822497 2.008922659407303e-08 1.5323253173031188 0.9993921897049711 0.005070803790994455 5.867141457421013 0.13652439061921798 2.691149862520776 0.05307493648568847 5.715310577299272e-13 12.242960164508878 1.5323252972138923 VTLILELLQHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTLILELLQHK 11 0 Q9H583;Q5T3Q7 Q9H583 HEATR1 HEAT repeat-containing protein 1;HEAT repeat-containing protein 1, N-terminally processed 0 34290800.0 7704000.0 9652800.0 16934000.0 False True 9972979.86854341 9115613.194506852 13852185.757513007 1.0 0.9140310433453447 1.3889715952606418 23.249593207271793 -6.860043588989651 1.1854231068649927 0.9533473508000585 1.4119996834466373 0.9536993183673665 0.04446148303504281 0.1467621146607697 0.39184495643738926 0.029251686280344923 0.0682896984276152 1.3802457260340047e-07 6.860043588989651 0.4586523326465788 VTLK(ub)QDTHGVGHDPAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTLKQDTHGVGHDPAK 16 1 A0A0A0MRK1;E9PAV9;Q5T3I0;Q5T3I0-3;F8W895;E9PPY4;F2Z3C6 A0A0A0MRK1 GPATCH4 G patch domain-containing protein 4 1 6313600.0 1447700.0 2155100.0 2710800.0 True False 1897948.7195467423 1833567.480514004 2430312.4198297323 1.0 0.9660785149937489 1.2804942487645958 20.856009582202134 -6.880184670372162 1.0787195186937324 0.9789219689742266 1.3028601484701343 0.9738361943750969 0.022791513675644984 0.12746888180328966 0.27127164183184577 0.016272334851312836 0.03937080812673792 1.3176963095809647e-07 6.880184670372162 0.32393817949590775 VTLK(ub)QDTHGVGHDPAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTLKQDTHGVGHDPAK 16 1 A0A0A0MRK1;E9PAV9;Q5T3I0;Q5T3I0-3;F8W895;E9PPY4;F2Z3C6 A0A0A0MRK1 GPATCH4 G patch domain-containing protein 4 1 7667800.0 2309100.0 2937800.0 2420900.0 True False 1920118.9604745929 2921973.4882923593 2927098.9970230972 1.0 1.5217669053016067 1.5244362757084648 20.872764264838416 VTLKGAKDCVEAAK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTLKGAKDCVEAAK 14 2 A0A024R4E5;Q00341;Q00341-2;H0Y394;H7C2D1 A0A024R4E5 HDLBP Vigilin 1 5049200.0 1782500.0 1357400.0 1909300.0 True False 2336874.761754552 1154881.211103758 1711743.951298847 1.0 0.49419901742473366 0.7324928059104248 21.156148988324208 -10.105843285278025 4.980463615945864 1.0000121983840746 0.6133459116689366 0.7782909281278184 0.09728303178600786 1.4707101591978167e-05 2.640565113640163e-06 0.09419720420378452 0.03139796349673007 7.837123935679002e-11 10.105843285278025 -0.38666628671513803 VTLKGAKDCVEAAK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTLKGAKDCVEAAK 14 2 A0A024R4E5;Q00341;Q00341-2;H0Y394;H7C2D1 A0A024R4E5 HDLBP Vigilin 1 5811600.0 1782500.0 1928600.0 2100500.0 True False 2441538.4202512573 1843388.0749726591 1604405.1611554238 1.0 0.7550108815338474 0.6571287790713183 21.2193590498471 -13.99999999998682 0.1265403171331068 2.1642878478713965 0.5138324734505683 0.9996615468189245 0.002652986157343066 11.943410160312462 0.1102649990237538 3.470153248783789 0.1272967620076478 1.0000000000303494e-14 13.99999999998682 -1.6504553744208281 VTLLDLMIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTLLDLMIAK 10 0 Q9UBB4;Q9UBB4-2;A0A1W2PQD2 Q9UBB4 ATXN10 Ataxin-10 0 3224760.0 889360.0 1288100.0 1047300.0 False True 1165959.5725744914 1095920.500974473 938935.4424109787 1.0 0.9399301028547938 0.8052898783941255 20.153086336029453 -6.957756629264671 0.4659747381575658 1.0036989216578656 0.7360387235522765 0.9996777301000143 0.001461452417752358 0.08051245022499115 0.024167596568831915 0.001847848797631995 0.011116135413831716 1.1021567651417619e-07 6.957756629264671 -0.26766019810558905 VTLLDLMIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTLLDLMIAK 10 0 Q9UBB4;Q9UBB4-2;A0A1W2PQD2 Q9UBB4 ATXN10 Ataxin-10 0 16182700.0 4210100.0 7332500.0 4640100.0 False True 6387029.499538114 6023958.085916016 3722982.201171921 1.0 0.9431548870021105 0.582897292307974 22.60671368317342 -6.9346881214017495 0.7072537555198359 1.004643085817782 0.49925862184870873 0.9973820333916709 0.009449828808152327 0.09027570053719305 0.06628403774029708 0.008863396838089168 0.03179891784832223 1.1622829810169566e-07 6.9346881214017495 -0.5053844639690732 VTLLDLMIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTLLDLMIAK 10 0 Q9UBB4;Q9UBB4-2;A0A1W2PQD2 Q9UBB4 ATXN10 Ataxin-10 0 7456860.0 889360.0 1813200.0 4754300.0 False True 1218180.4260503007 1733086.8285494267 3631432.257882044 1.0 1.422684843302403 2.9810298870555783 20.216296397552345 -6.946749777414573 0.5934547892469841 0.9821637052888683 3.500431555501388 0.9989209103958534 0.027984442175200124 0.08481771929503679 0.04157036589190384 0.02891018709143767 0.13068771980753463 1.1304470440846995e-07 6.946749777414573 2.5182678502125198 up VTLLDLMIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTLLDLMIAK 10 0 Q9UBB4;Q9UBB4-2;A0A1W2PQD2 Q9UBB4 ATXN10 Ataxin-10 0 11960800.0 4210100.0 5312800.0 2437900.0 False True 5450057.443478015 5017138.009673465 1994227.2149663966 1.0 0.9205660787442493 0.36590939373544623 22.37784000526587 -6.93271727222956 0.7241427246441797 1.0076431125431107 0.24374045746688172 0.997045810116121 0.015330697512881799 0.09125136067261864 0.0709474207433137 0.01419994789387163 0.04945842317502137 1.1675694629683488e-07 6.93271727222956 -0.7639026550762289 down VTLLLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTLLLFK 7 0 Q9Y3C4-3;Q9Y3C4 Q9Y3C4-3 TPRKB EKC/KEOPS complex subunit TPRKB 0 24589000.0 7146500.0 8696300.0 8746200.0 False True 9369130.706804438 7398845.937911894 7841227.123474558 1.0 0.7897046342344651 0.836921521201511 23.159483766284296 -10.731778196992648 6.84888156661773 1.0027170306247561 0.8133130777179884 0.9542199056671679 0.01927621338532192 0.0008098788254061475 3.171711465830995e-05 0.018901211282552635 0.006221371118274354 1.854478501412773e-11 10.731778196992648 -0.1894039529067677 VTLLLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTLLLFK 7 0 Q9Y3C4-3;Q9Y3C4 Q9Y3C4-3 TPRKB EKC/KEOPS complex subunit TPRKB 0 17719200.0 6224900.0 4120900.0 7373400.0 False True 6027293.956837993 5766396.860209603 5442085.342741469 1.0 0.9567140580007051 0.902906906766576 22.523078997436695 -6.96819131819479 0.29824281252513324 1.009528993579121 0.848410174491166 0.9999646153246908 0.00023617769423943703 0.07689406290095169 0.011119743735843774 0.0009005506358106069 0.004834783441642198 1.0759911066954066e-07 6.96819131819479 -0.161118819087955 VTLLLFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTLLLFK 7 0 Q9Y3C4-3;Q9Y3C4 Q9Y3C4-3 TPRKB EKC/KEOPS complex subunit TPRKB 0 12902700.0 3174000.0 3263400.0 6465300.0 False True 4815190.050481919 2681020.772939424 5187430.621158347 1.0 0.556783999142692 1.07730547844922 22.199161310171064 -6.681143657692872 1.897645798509879 0.7198639809862746 1.07535093011534 0.3294456933550003 0.18779806841202423 0.43598727513500485 3.0364037295349315 0.07937757247620641 0.20906043049979853 2.0838014807635028e-07 6.681143657692872 0.35548694912906553 VTLLLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTLLLFK 7 0 Q9Y3C4-3;Q9Y3C4 Q9Y3C4-3 TPRKB EKC/KEOPS complex subunit TPRKB 0 30025700.0 7146500.0 8967200.0 13912000.0 False True 9788754.176900765 8570999.453435054 10626272.126633788 1.0 0.875596556879594 1.0855591972785847 23.222693827807188 -6.746154832846347 1.6638859061386198 0.9265145592895656 1.0858622241805405 0.6323645948208731 0.05226831181503104 0.30678776825456294 1.6698058664594726 0.024827439241738664 0.06052412876435591 1.7940938899756872e-07 6.746154832846347 0.15934766489097485 VTLLLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTLLLFK 7 0 Q9Y3C4-3;Q9Y3C4 Q9Y3C4-3 TPRKB EKC/KEOPS complex subunit TPRKB 0 13916500.0 6224900.0 3171600.0 4520000.0 False True 5176280.159827768 3154513.9612866887 5465111.101881294 1.0 0.6094171613368875 1.0557989392257192 22.30348427287097 -6.675510082886476 1.917651887204997 0.7518854618810973 1.0540524373596802 0.30374675622607494 0.16570314782930165 0.4485960410851058 3.185357804379628 0.06943328671476161 0.1841984233088472 2.111008184587243e-07 6.675510082886476 0.30216697547858296 VTLLLFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTLLLFK 7 0 Q9Y3C4-3;Q9Y3C4 Q9Y3C4-3 TPRKB EKC/KEOPS complex subunit TPRKB 0 13078500.0 3174000.0 7095600.0 2808900.0 False True 4108805.568893656 6700723.622466304 2297709.021747858 1.0 1.6308203223815607 0.5592158069349927 21.970287632263513 -6.747190479933298 1.660410870148168 1.37217475973431 0.557550421761202 0.6367619976094729 0.26504464633320635 0.3049508126625947 1.6532837341860813 0.1261507366605726 0.30714858907822845 1.7898206732149346e-07 6.747190479933298 -0.814624337973108 VTLLLSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTLLLSSK 8 0 Q9NTZ6;A6PVI1;A6PVI0;Q5JX62 Q9NTZ6 RBM12 RNA-binding protein 12 0 49794000.0 11635000.0 12760000.0 25399000.0 False True 15253597.673500294 10856257.738090442 22770955.124411795 1.0 0.711717849812622 1.4928252083094615 23.862646217285672 -6.80677448833371 1.4278624934007065 0.8422763242368958 1.5055290416649019 0.8512823097285697 0.12437238558607723 0.211233168397538 0.8493468766515797 0.06849929040301 0.1587106089870791 1.560362526037414e-07 6.80677448833371 0.6632527174280061 VTLLLSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTLLLSSK 8 0 Q9NTZ6;A6PVI1;A6PVI0;Q5JX62 Q9NTZ6 RBM12 RNA-binding protein 12 0 24303100.0 10028000.0 4826900.0 9448200.0 False True 9709666.629049677 6754306.341950971 6973432.9800756695 1.0 0.6956270075991312 0.7181948924191012 23.21099033243793 -10.672477013760743 6.633180465992463 1.0019700648332401 0.7069109500091163 0.9955729233906108 0.009213300397138103 0.00026998270121492694 1.3330777257075792e-05 0.00897258120446531 0.0029735799168101695 2.1258028562481926e-11 10.672477013760743 -0.29505911482412384 VTLLLSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTLLLSSK 8 0 Q9NTZ6;A6PVI1;A6PVI0;Q5JX62 Q9NTZ6 RBM12 RNA-binding protein 12 0 38536000.0 11635000.0 10262000.0 16639000.0 False True 15936773.924052421 9808590.908104017 12709210.890961735 1.0 0.6154690375133262 0.7974770145782442 23.925856278808563 -10.117392191077492 4.841524289530938 1.0000140992244575 0.7064730260463784 0.7761761464219844 0.07430444549964127 103622762.21691214 0.5749081591811184 18077.231085180323 0.025436388075042362 7.631463104931352e-11 10.117392191077492 -0.2935410731780791 VTLLLSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTLLLSSK 8 0 Q9NTZ6;A6PVI1;A6PVI0;Q5JX62 Q9NTZ6 RBM12 RNA-binding protein 12 0 23442400.0 10028000.0 5806100.0 7608300.0 False True 8338726.315724398 5774821.386879386 9199160.353195436 1.0 0.6925303899217513 1.103185307311083 22.991395607872207 -6.706325028235959 1.808477099272637 0.8102679327056751 1.1021131224158507 0.4475769574903228 0.1296429752295802 0.38249883171463345 2.4362782594912042 0.05709985419936708 0.14570121660067273 1.9664140644110724e-07 6.706325028235959 0.2918451897101756 VTLSEGPHHVALFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTLSEGPHHVALFK 14 0 O60313-10;O60313-11;A0A2R8Y3X5;E5KLJ9;C9JMB8;A0A2R8YE78;O60313-2;O60313;O60313-9;O60313-13;A0A2R8YDM2;A0A2R8YFD1;A0A2R8YGE5;A0A2R8Y4Q3;A0A2R8YD53;A0A2R8Y4G4;A0A2R8YE54 O60313-10 OPA1 Dynamin-like 120 kDa protein, mitochondrial;Dynamin-like 120 kDa protein, form S1 0 9829200.0 2551200.0 3630100.0 3647900.0 False True 3344647.9058559425 3088503.2300189747 3270450.3011276745 1.0 0.9234165499488004 0.9778160192591991 21.673422914357857 -10.08851265422893 4.802996625319892 1.0000020687738644 0.9506162846041589 0.5235362556935086 0.022208490349988428 4.919912834149404e-07 9.337310316004273e-08 0.021504179054324505 0.007167759438892699 8.156190217371475e-11 10.08851265422893 -0.049385784169705516 VTLSEGPHHVALFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTLSEGPHHVALFK 14 0 O60313-10;O60313-11;A0A2R8Y3X5;E5KLJ9;C9JMB8;A0A2R8YE78;O60313-2;O60313;O60313-9;O60313-13;A0A2R8YDM2;A0A2R8YFD1;A0A2R8YGE5;A0A2R8Y4Q3;A0A2R8YD53;A0A2R8Y4G4;A0A2R8YE54 O60313-10 OPA1 Dynamin-like 120 kDa protein, mitochondrial;Dynamin-like 120 kDa protein, form S1 0 8825900.0 2551200.0 3101600.0 3173100.0 False True 3494447.5835876646 2964561.0563803776 2423679.1320458385 1.0 0.8483632921850082 0.6935800506578227 21.73663297588075 -6.970868911566436 0.23651501259959096 1.0580365798346258 0.4794490629667211 0.9999883867580767 0.000426271158831694 0.07602174335240681 0.008014419504928275 0.003792983171272058 0.015185139323524876 1.0693776138823833e-07 6.970868911566436 -0.5785875168679048 VTLSFPSTLQTGTGTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTLSFPSTLQTGTGTLK 17 0 E9PLK3;P55786;P55786-2;A6NEC2;E9PP11;E9PJY4;E9PPD4;A6NEC2-3 E9PLK3 NPEPPS;NPEPPSL1 Puromycin-sensitive aminopeptidase;Puromycin-sensitive aminopeptidase-like protein 0 54297000.0 12294000.0 17475000.0 24528000.0 False True 16117553.055265365 14867798.117016505 21990077.849189807 1.0 0.9224600077962465 1.3643558531365265 23.942129396725363 -6.86159658521493 1.1775331747619224 0.9577336628526949 1.3864275311610441 0.9555583941299893 0.040613701718269446 0.14517225021509614 0.3815761638446494 0.026881468787242905 0.06287108421257964 1.3753189112821307e-07 6.86159658521493 0.4286938683083492 VTLSFPSTLQTGTGTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTLSFPSTLQTGTGTLK 17 0 E9PLK3;P55786;P55786-2;A6NEC2;E9PP11;E9PJY4;E9PPD4;A6NEC2-3 E9PLK3 NPEPPS;NPEPPSL1 Puromycin-sensitive aminopeptidase;Puromycin-sensitive aminopeptidase-like protein 0 38768100.0 11205000.0 4545100.0 23018000.0 False True 10849303.408306917 6359982.132383381 16988895.274801716 1.0 0.586211104347379 1.5658973332604873 23.37109908000175 -6.791938548305104 1.4883943524386472 0.7693163640809187 1.5769076850839256 0.807603056662077 0.17613609727562607 0.2324709989120988 1.0173110050149208 0.09313348482160297 0.21776183691755152 1.6145870011024328e-07 6.791938548305104 0.8075913210030069 VTLSFPSTLQTGTGTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTLSFPSTLQTGTGTLK 17 0 E9PLK3;P55786;P55786-2;A6NEC2;E9PP11;E9PJY4;E9PPD4;A6NEC2-3 E9PLK3 NPEPPS;NPEPPSL1 Puromycin-sensitive aminopeptidase;Puromycin-sensitive aminopeptidase-like protein 0 54400000.0 12294000.0 11904000.0 30202000.0 False True 16839424.03285779 11378041.918736156 23068909.629714914 1.0 0.6756788056726194 1.3699346001800234 24.005339458248255 -6.779663593001161 1.537050324970103 0.8162813944447954 1.3753888414380007 0.7662384988965666 0.1371331985528896 0.25109905922828335 1.1716974046490296 0.07027007282435352 0.16586362600929389 1.6608729309995746e-07 6.779663593001161 0.5591074469932052 VTLSFPSTLQTGTGTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTLSFPSTLQTGTGTLK 17 0 E9PLK3;P55786;P55786-2;A6NEC2;E9PP11;E9PJY4;E9PPD4;A6NEC2-3 E9PLK3 NPEPPS;NPEPPSL1 Puromycin-sensitive aminopeptidase;Puromycin-sensitive aminopeptidase-like protein 0 26925500.0 11205000.0 7359500.0 8361000.0 False True 9317453.965665337 7319852.912753625 10109246.44310385 1.0 0.7856065551519934 1.084979489070325 23.151504355436025 -6.714488769769134 1.779295639822664 0.8688014190681728 1.0843697881830268 0.48630590742270485 0.09028397442208407 0.3661464255659812 2.262293459184901 0.04033916554953233 0.10192300682130478 1.9297952372746002e-07 6.714488769769134 0.215568369114854 VTLSLFGLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTLSLFGLR 9 0 Q9P107;Q9P107-2;K7EJC2 Q9P107 GMIP GEM-interacting protein 0 3734130.0 828320.0 2479600.0 426210.0 False True 1085935.5414622896 2109653.345405099 382109.87769500894 1.0 1.9427058649948048 0.35187160112696075 20.05050704007916 -6.746146023841833 1.6640184505289695 1.5568722010842506 0.3495982299743771 0.6322694145680727 0.3960791668618726 0.30681096771760047 1.6702131750512872 0.18812643569147655 0.4585995630071367 1.7941302808167347e-07 6.746146023841833 -1.2072739711098734 VTLSLFGLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTLSLFGLR 9 0 Q9P107;Q9P107-2;K7EJC2 Q9P107 GMIP GEM-interacting protein 0 6877920.0 828320.0 2150400.0 3899200.0 False True 1134572.2885063237 2055388.21757814 2978289.2665447462 1.0 1.8115974084684197 2.625032619530744 20.113717101602052 -6.971097240885451 0.23047841825896154 0.6711530645204781 3.788732591429846 0.9999897214789869 0.002126915638392041 0.07594824399275615 0.0077443088910398 0.020827398638624692 0.08071539579279104 1.0688155388439225e-07 6.971097240885451 3.117579526909368 VTLTIFVAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTLTIFVAR 9 0 Q9HC16 Q9HC16 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G 0 27616900.0 7937100.0 12314000.0 7365800.0 False True 12041160.979735369 10116470.490278864 5909946.401455167 1.0 0.84015739905017 0.4908120081943337 23.521471164195976 -6.958273191090917 0.4591240867279504 1.0102723500987976 0.3066349609396629 0.9997006921413513 0.0036784261966976823 0.08032384753995503 0.023454919218062004 0.004737483489111119 0.028862241168679838 1.1008466088315385e-07 6.958273191090917 -0.7036373891591347 down VTLTIFVAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTLTIFVAR 9 0 Q9HC16 Q9HC16 APOBEC3G DNA dC->dU-editing enzyme APOBEC-3G 0 21866200.0 7937100.0 9017200.0 4911900.0 False True 10274732.413631333 8515384.893244151 4017984.6003500656 1.0 0.8287695046877248 0.3910549139965403 23.292597486288425 -6.954983044399706 0.5011672893982214 1.0086780681254963 0.1922299905803453 0.9995365090125177 0.005520268959541294 0.08154445988073548 0.028143478551313536 0.006459727703753359 0.03610896830368132 1.1092181201919731e-07 6.954983044399706 -0.816448077545151 down VTLTLPVLNAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTLTLPVLNAAR 12 0 O95336;M0R261 O95336 PGLS 6-phosphogluconolactonase 0 13636800.0 4938400.0 4627000.0 4071400.0 False True 6474290.223533634 3936669.635904738 3650130.58362652 1.0 0.6080465193845024 0.5637885324260761 22.62629060812859 -13.999999999999998 0.30789165081819997 4.742392903049902 0.5537641723395017 0.9996673517584579 0.003575404632451357 17.121157724183217 0.1764774329036195 41.00100963504482 0.015470901421859825 1.0000000000000041e-14 13.999999999999998 -4.1886287307104 VTLTLPVLNAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTLTLPVLNAAR 12 0 O95336;M0R261 O95336 PGLS 6-phosphogluconolactonase 0 13010200.0 4955200.0 4079300.0 3975700.0 False True 4797899.888339346 5708185.763268465 2934344.901556575 1.0 1.1897259001050537 0.6115894390977411 22.193971624391292 -6.818310104774454 1.3793152233690933 1.1024370851719585 0.5994337577783415 0.8804243381547527 0.0832071917014365 0.1956843098636827 0.7320084530351394 0.047412220022152236 0.1093221469205571 1.519462181512483e-07 6.818310104774454 -0.503003327393617 VTLTLPVLNAAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTLTLPVLNAAR 12 0 O95336;M0R261 O95336 PGLS 6-phosphogluconolactonase 0 24758400.0 4938400.0 5923000.0 13897000.0 False True 6764259.935241982 5661302.275258253 10614814.81769909 1.0 0.8369433359239657 1.569249987333516 22.68950066965148 -6.848275628397979 1.2433739021336245 0.9130980495500055 1.5975665519371292 0.9377586092524445 0.07831720832189754 0.15936530825346198 0.47497707327188554 0.04930877368010557 0.11398554018958569 1.418157191438031e-07 6.848275628397979 0.6844685023871236 VTLTLPVLNAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTLTLPVLNAAR 12 0 O95336;M0R261 O95336 PGLS 6-phosphogluconolactonase 0 10898900.0 4955200.0 2698100.0 3245600.0 False True 4120468.3525805287 2683564.7997690844 3924239.954041129 1.0 0.6512766438524995 0.9523771615873454 21.974376899825568 -10.14651551893596 7.271365065659653 1.0000001233239588 0.8018269027199225 0.3661139727268642 0.12292377162303492 2.4575964422800055e-07 2.878115582327187e-08 0.11902050457557024 0.03967347669575152 7.136487033791505e-11 10.14651551893596 -0.1981732206040363 VTLTSEEEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTLTSEEEAR 10 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 110862000.0 10200000.0 45917000.0 54745000.0 False True 13372298.776940493 39066362.58306413 49080512.55112105 1.0 2.921439554613533 3.6703122903413314 23.672744158739178 -9.390826614486928 0.2926157261485759 3.18955674321619e-22 3.994439105850457 0.9987478661083994 0.039795903650465356 0.7821037175422976 0.11426264911837884 1.0471790933596168 0.2690741571072088 4.066056279216777e-10 9.390826614486928 3.994439105850457 VTLTSEEEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTLTSEEEAR 10 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 84272000.0 20541000.0 5989000.0 57742000.0 False True 19888937.19857493 8380438.932222407 42617637.977131024 1.0 0.421361827861917 2.1427810622371837 24.245462849417283 -6.816077739524996 1.3890479726388592 0.6868342013904969 2.1772034983630473 0.8750510330723981 0.2528222694875412 0.1986343612095375 0.754154192493245 0.14307569575291096 0.33011489560324375 1.5272926455263968e-07 6.816077739524996 1.4903692969725504 up VTLTSEEEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTLTSEEEAR 10 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 247216200.0 2710300.0 240890000.0 3615900.0 False True 4111723.249471067 197901297.41783926 2901215.78009473 1.0 48.13098679326176 0.7055960734876656 21.971311732675954 -6.240174707812471 24.998778174957017 9.999999999999998 0.707597829653939 0.0 22.61984495873679 6344.8545040540175 16142817.953966813 9.71359065844674 89.32355408585876 5.752084961418362e-07 6.240174707812471 -9.29240217034606 VTLTSEEEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTLTSEEEAR 10 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 82387000.0 10200000.0 34738000.0 37449000.0 False True 13971215.644635525 33203160.29679575 28604317.486364953 1.0 2.3765405345772215 2.0473749896880338 23.73595422026207 -10.28555968680291 5.031880667014316 0.9996920295273332 2.2119577621330775 0.9475761221897403 0.13438127098217945 0.00046439182617142325 6.593510969533718e-05 0.13014547806895108 0.04337136871279011 5.1813187820691805e-11 10.28555968680291 1.2122657326057444 VTLTSEEEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTLTSEEEAR 10 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 36797400.0 20541000.0 9769600.0 6486800.0 False True 17080751.620591827 9716969.22568623 7843159.888425571 1.0 0.5688841709970108 0.4591811919429934 24.02586812485156 -13.999999999999998 0.19217302598162103 3.3286546215063124 0.3821770470011069 0.999488359300964 0.00527992387722085 12.386917913746597 0.1390189824108039 10.80923638526173 0.07416082549044217 1.0000000000000041e-14 13.999999999999998 -2.9464775745052054 VTLTSEEEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTLTSEEEAR 10 0 P00338;P00338-3;P00338-4 P00338 LDHA L-lactate dehydrogenase A chain 0 26394200.0 2710300.0 13875000.0 9808900.0 False True 3508536.7780001555 13102844.05289477 8023780.8478132365 1.0 3.7345608388814755 2.2869308077730177 21.742438054768403 -9.725419169207687 6.3091425056395485 0.9999999822317269 3.0107458233302293 0.7200758692728769 0.5909924854348517 58664976.41710412 90430899.93425593 10.9562426504402 0.20231245650108487 1.8818319197645924e-10 9.725419169207687 2.0107458410985024 VTMLFLGLHNVR ddPTM_RPMI8226_Bortezomib_1h_R1 2 VTMLFLGLHNVR 12 0 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 89999000.0 28186000.0 47475900.0 14337100.0 False True 36952118.95361227 40392680.77960871 12853634.4231743 1.0 1.0931086477155896 0.34784566588211274 25.13915375973905 -6.875591981019995 1.1041422328622121 1.0549320208252522 0.2993090158710703 0.9699500034317422 0.057475799854719185 0.13160368619265378 0.2965226047876751 0.04024670488622096 0.0963218514944926 1.3317049651545832e-07 6.875591981019995 -0.7556230049541819 down VTMLFLGLHNVR ddPTM_RPMI8226_Bortezomib_2h_R1 2 VTMLFLGLHNVR 12 0 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 137529700.0 57601000.0 39433900.0 40494800.0 False True 55772487.78419334 55180061.915071815 29887997.06204016 1.0 0.9893778116656037 0.5358914089988077 25.733050289392516 -6.911944603552629 0.8823922102437043 1.0131920455915204 0.47478207892365554 0.9916348597542125 0.019785118588282354 0.1031459884245234 0.1318975452665404 0.01635572694153194 0.04578105125770476 1.2247724151887377e-07 6.911944603552629 -0.5384099666678649 VTMLFLGLHNVR ddPTM_RPMI8226_Bortezomib_8h_R1 2 VTMLFLGLHNVR 12 0 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 642890200.0 148045200.0 210993000.0 283852000.0 False True 224595391.95387724 173339650.65416676 227748527.783249 1.0 0.7717863182596537 1.0140391830924975 27.742753087222596 -11.066657072206752 11.429093832987487 1.6188247800878783 0.8929127506760757 0.2066899554359245 0.09889931792798176 0.041280354601112464 0.000240756770831773 0.002534830427426678 0.03191961760719549 8.57714847069774e-12 11.066657072206752 -0.7259120294118027 VTMLFLGLHNVR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VTMLFLGLHNVR 12 0 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 189025600.0 28186000.0 63211000.0 97628600.0 False True 38607125.89800954 60418129.009175904 74570735.40413168 1.0 1.5649475997976547 1.9315277599562601 25.20236382126194 -8.557166264514617 0.11486134639815102 1.9177997213584735e-17 2.9096355164501078 0.9999606497509027 0.0024035349202634936 0.18074725417634852 0.029450053866296327 0.37525049353963846 0.32497935793566274 2.77225857500479e-09 8.557166264514617 2.9096355164501078 VTMLFLGLHNVR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VTMLFLGLHNVR 12 0 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 141016100.0 57601000.0 41015800.0 42399300.0 False True 47897783.65696463 40794839.7444011 51264797.59778656 1.0 0.8517062091341523 1.070295819216519 25.513455564826792 -6.724013516648067 1.744987236927969 0.9101687344436091 1.070032051133983 0.531354631548528 0.06237374360086455 0.34756751753575366 2.0704210485241403 0.028359245425629842 0.07085539309959317 1.8879325896172658e-07 6.724013516648067 0.1598633166903738 VTMLFLGLHNVR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VTMLFLGLHNVR 12 0 P14868;P14868-2;H7BZ35 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 594999500.0 148045200.0 249090300.0 197864000.0 False True 191647429.80717564 235228205.83702835 161854782.25608557 1.0 1.227400785252905 0.8445444972517206 27.513879409315045 -6.745779681018065 1.665309751075085 1.134386993287325 0.8440144522662851 0.6306928194051941 0.0955421784189737 0.3074569443366265 1.6761942619710126 0.045346461226735586 0.11058782458939242 1.7956443319331376e-07 6.745779681018065 -0.2903725410210398 VTNEDFK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTNEDFKK 8 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 5319400.0 1180600.0 2619000.0 1519800.0 True False 1547778.0329466627 2228255.40878204 1362545.6749510227 1.0 1.4396479090350462 0.8803236936739602 20.561767158553163 -6.697111506287157 1.8414317858315814 1.2737747595784548 0.8820880926759243 0.40380005420728815 0.18568073132376606 0.40154088783481623 2.6450898706575456 0.08051147688483791 0.2077756045611797 2.0085770387912408e-07 6.697111506287157 -0.3916866669025305 VTNEDFK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTNEDFKK 8 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 7266900.0 2439400.0 3086700.0 1740800.0 True False 2361962.5822600527 4319235.406927852 1284832.2571194198 1.0 1.8286637728168307 0.5439680826315306 21.171554679353296 -6.732549154084985 1.7139700699554814 1.4972621134076058 0.5443726539071814 0.5710470504119018 0.3482854230908092 0.3314703579107348 1.9088179846210946 0.16095747915238562 0.3982522964592455 1.8511893620269897e-07 6.732549154084985 -0.9528894595004245 VTNEDFK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTNEDFKK 8 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 4634200.0 1180600.0 2053200.0 1400400.0 True False 1617099.724515364 1962482.8349755574 1069654.3621433263 1.0 1.2135818250564 0.661464686393349 20.624977220076055 -6.8018248075034755 1.4485048485061771 1.1175720924796642 0.6535005523804209 0.8374230128203977 0.09165606918888729 0.21816817531903748 0.9035265580505825 0.049775340162834 0.11562999953968076 1.5782477995708594e-07 6.8018248075034755 -0.46407154009924323 VTNEDFK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTNEDFKK 8 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 6342400.0 2439400.0 2576700.0 1326300.0 True False 2028469.1837433304 2562818.805665096 1603623.1978816711 1.0 1.263425062704516 0.790558323850082 20.951959954787572 -6.755526319163386 1.629479628579919 1.153861511216779 0.7892123684278144 0.6723754973861599 0.11073697149206373 0.2904979960283083 1.5191479458847517 0.05364957556042451 0.12949564166314056 1.755794486118568e-07 6.755526319163386 -0.36464914278896454 VTNGAFTGEISPGMIK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VTNGAFTGEISPGMIK 16 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 155491100.0 31724800.0 71879600.0 51886700.0 False True 41591520.023400255 61155443.86448628 46517962.01637134 1.0 1.4703825161975075 1.1184482315192945 25.309786075575925 -10.496951981197462 5.570519147781718 0.9995357821890465 1.2944153738583983 0.48270099488442186 0.14367657007550438 0.000829610141599434 7.491789613666498e-05 0.13932862553463846 0.046371413595219076 3.184549609564381e-11 10.496951981197462 0.29487959166935185 VTNGAFTGEISPGMIK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VTNGAFTGEISPGMIK 16 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 115443300.0 36175700.0 15037200.0 64230400.0 False True 35027322.20507704 21041632.377962053 47406531.36930336 1.0 0.6007205533659713 1.353415801863153 25.06197736433775 -6.762577232123033 1.6026520441097636 0.7688215357230737 1.3565328025448553 0.7014425732911649 0.16800649135092288 0.27861002362595294 1.4109253446383647 0.08268762356926365 0.1982183114481361 1.7275187424249728e-07 6.762577232123033 0.5877112668217817 VTNGAFTGEISPGMIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTNGAFTGEISPGMIK 16 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 226118000.0 16207000.0 185240000.0 24671000.0 False True 24587203.890409727 152182474.71327418 19794766.036316585 1.0 6.189499033382693 0.8050840642370709 24.551404342097758 -6.654573265776688 1.9923275752706373 4.355254615542184 0.8277498181476678 0.21274737313108727 2.212472226680336 0.4974273106978602 3.7897063742130306 0.8990445059926643 2.4511572402437447 2.215270347162346e-07 6.654573265776688 -3.527504797394516 VTNGAFTGEISPGMIK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VTNGAFTGEISPGMIK 16 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 112711000.0 31724800.0 32827200.0 48159000.0 False True 43454315.89048372 31376785.758966357 36784836.06573866 1.0 0.722063737881505 0.84651743588476 25.372996137098816 -10.126407801734121 4.91952970230836 1.0000108694185057 0.7842905868822513 0.8002214434345134 0.05080800945478187 6.057391767115805e-06 1.0756598997829338e-06 0.04919712141910998 0.016398214538925086 7.474673004353514e-11 10.126407801734121 -0.21572028253625442 VTNGAFTGEISPGMIK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VTNGAFTGEISPGMIK 16 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 70048300.0 36175700.0 16981800.0 16890800.0 False True 30081697.40524045 16890315.672776617 20422588.18576468 1.0 0.5614814697868147 0.6789041160359162 24.842382639772026 -10.21887125849842 8.016294504051464 1.0000002078763888 0.6201927929113714 0.9331085281194634 0.04793759459293862 1.7807394882271297e-07 1.734222685528596e-08 0.04641540196903458 0.015471792126307834 6.041276893974543e-11 10.21887125849842 -0.37980741496501735 VTNGAFTGEISPGMIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTNGAFTGEISPGMIK 16 0 P60174;P60174-3 P60174 TPI1 Triosephosphate isomerase 0 73000000.0 16207000.0 31446000.0 25347000.0 False True 20980280.98773141 29696002.456744406 20734106.0821827 1.0 1.415424439458636 0.9882663675623476 24.322530664190207 -6.65257427968784 1.9997080833536014 1.2690293319716484 0.9900764459019125 0.20436433813654986 0.177198321760269 0.5022878995160485 3.8529861652984247 0.0717988424542537 0.19625501919311256 2.2254903748217228e-07 6.65257427968784 -0.2789528860697359 VTNGELLAQYMADAASELGPTTPYGK(ub)TLIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTNGELLAQYMADAASELGPTTPYGKTLIK 30 1 Q9NR46;B7ZC39;B7ZC38;Q9NR46-2 Q9NR46 SH3GLB2 Endophilin-B2 1 44567500.0 5772500.0 6496000.0 32299000.0 True False 7472615.042986352 6134491.889557072 26420913.415726446 1.0 0.8209297353427545 3.53569844876789 22.833181772089812 -6.89113329901299 1.015634749216488 0.8580709746913215 3.774462387998289 0.9816144893545132 0.16809545624979882 0.11822921187953438 0.21650562999914402 0.12591516836340705 0.3152227727305737 1.2848922244625234e-07 6.89113329901299 2.9163914133069673 up VTNLHLMLQLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTNLHLMLQLVR 12 0 O60763;O60763-2 O60763 USO1 General vesicular transport factor p115 0 25914400.0 17654400.0 4262000.0 3998000.0 False True 17093970.735529985 5963838.826036384 2950803.862570913 1.0 0.34888551749070723 0.172622494107682 24.026984221849723 -13.999999999999742 0.18338336440307296 4.414320830509901 0.03739181008254605 0.9994944461937605 0.008000797138623882 12.250390802023563 0.13577837004598353 14.91598131678636 0.12791566865561269 1.000000000000593e-14 13.999999999999742 -4.3769290204273545 VTNLHLMLQLVR ddPTM_RPMI8226_Bortezomib_8h_R1 2 VTNLHLMLQLVR 12 0 O60763;O60763-2 O60763 USO1 General vesicular transport factor p115 0 389093900.0 90272900.0 143800000.0 155021000.0 False True 136950589.13300258 118137766.48547201 124381031.40188204 1.0 0.8626305825580635 0.9082183011355042 27.02908023133009 -10.035496969832616 6.293275036480911 1.000000097545859 0.8854244428330127 0.8938679779470057 0.018611108175395127 2.5472806330856903e-08 3.904119555832841e-09 0.01802014344436266 0.006006709334813108 9.215163183329985e-11 10.035496969832616 -0.11457565471284625 VTNLHLMLQLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VTNLHLMLQLVR 12 0 O60763;O60763-2 O60763 USO1 General vesicular transport factor p115 0 42576510.0 24450200.0 5863810.0 12262500.0 False True 20331424.62751541 5832220.491654842 14826532.05460603 1.0 0.28685744351440295 0.7292421621326345 24.277207972903387 -10.15665850350335 6.715681576400289 1.0000010673532835 0.5080498028250098 0.622477480001795 0.1806028051032308 2.8863773264918523e-06 3.624006048029157e-07 0.17486829450016664 0.05828930470359628 6.971745041959395e-11 10.15665850350335 -0.49195126452827376 VTNLHLMLQLVR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VTNLHLMLQLVR 12 0 O60763;O60763-2 O60763 USO1 General vesicular transport factor p115 0 320979900.0 90272900.0 122542000.0 108165000.0 False True 116860048.59489001 115722429.97692469 88480079.86662298 1.0 0.9902651194172525 0.7571456706590142 26.80020655342254 -6.915676602401901 0.8561705117934791 1.0059877461378044 0.7230520294735422 0.9928934225860158 0.009463445215635921 0.1007829666128806 0.11928731204102101 0.00797226564255032 0.022977286571352628 1.2142927375634246e-07 6.915676602401901 -0.2829357166642622 VTNLLMLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTNLLMLK 8 0 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-2;X6R242;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EKJ7;K7ES59;K7ELW5 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 0 26499500.0 9323300.0 5831200.0 11345000.0 False True 9027336.944816392 8159628.569306277 8373404.157295392 1.0 0.9038799170990993 0.9275608308941546 23.10586902622844 -10.471832396743281 6.067568178996123 1.00005260531882 0.915720373996627 0.9440976519224596 0.009667692573453493 6.883986303858272e-06 5.992341788130328e-07 0.009366540940033988 0.003120234361103201 3.374174999536655e-11 10.471832396743281 -0.08433223132219292 VTNLLMLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTNLLMLK 8 0 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-2;X6R242;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EKJ7;K7ES59;K7ELW5 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 0 42663000.0 6263000.0 31896000.0 4504000.0 False True 9501428.886631465 26203909.59541456 3613782.4258266715 1.0 2.7578914611762797 0.3803409433407719 23.179713060940653 -6.70864235883831 1.7996421896501038 2.0822455373910613 0.38607337101357964 0.4586500171964861 0.740934133721756 0.3779081894738244 2.384913640214467 0.3277091574706321 0.8340341615768002 1.9559495156190186e-07 6.70864235883831 -1.6961721663774818 VTNLLMLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTNLLMLK 8 0 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-2;X6R242;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EKJ7;K7ES59;K7ELW5 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 0 62784000.0 15394000.0 15197000.0 32193000.0 False True 21085577.80720782 14525546.290241363 24589676.43564703 1.0 0.6888853804744208 1.1661846149286639 24.329753220482207 -6.730816662500594 1.7204051959179631 0.8129425294653609 1.1659354847011798 0.5629975779116645 0.1307766649349412 0.33470094038754383 1.9411672129596853 0.06023183897645652 0.14931451294431686 1.8585888931648858e-07 6.730816662500594 0.35299295523581886 VTNLLMLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTNLLMLK 8 0 O95758-1;O95758-6;O95758;O95758-5;O95758-4;O95758-2;X6R242;P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;K7EKJ7;K7ES59;K7ELW5 O95758-1;P26599 PTBP3;PTBP1 Polypyrimidine tract-binding protein 3;Polypyrimidine tract-binding protein 1 0 21856100.0 9323300.0 7432000.0 5100800.0 False True 7752737.042221101 7391962.340863494 6167353.696565507 1.0 0.9534648602947782 0.7955066272696135 22.886274301662716 -6.948646463939013 0.5735139113279981 1.0019376775651032 0.7393075479520974 0.9990907117085573 0.0026390329449934263 0.08403391298505387 0.03824760891435469 0.002784817139627364 0.013172587123248135 1.1255208278424832e-07 6.948646463939013 -0.2626301296130058 VTNLSEDTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTNLSEDTR 9 0 O75821;K7EL20;K7ER90;K7ENA8 O75821 EIF3G Eukaryotic translation initiation factor 3 subunit G 0 5694020.0 2012000.0 828620.0 2853400.0 False True 1948130.1613131203 1159492.2871962148 2106008.9398348806 1.0 0.5951821445106465 1.0810411858801794 20.89365864140952 -6.685509770062395 1.8817859290559882 0.7451609542742312 1.0793062402550706 0.34983066817924147 0.1713659338944687 0.42635076783765 2.923350430494555 0.07293876789260523 0.1910607900660538 2.0629572576769756e-07 6.685509770062395 0.33414528598083937 VTNVDEEK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTNVDEEKQR 10 1 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 1 6356600.0 2010000.0 2154700.0 2191900.0 True False 2635129.4648676896 1833227.158954815 1965103.214189464 1.0 0.6956877008875394 0.7457330808177701 21.32944241305925 -10.383865336060873 5.852089294851945 1.0000692436108918 0.7207103908526682 0.9764849832853646 0.020430940802132484 1.8462396623485107e-05 1.943808033330439e-06 0.019787060368626375 0.006594057789500535 4.1317559762680486e-11 10.383865336060873 -0.2793588527582236 VTNVDEEK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTNVDEEKQR 10 1 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 1 4532400.0 1219200.0 1835600.0 1477600.0 True False 1180497.1633563377 2568564.6525275456 1090572.23295017 1.0 2.175832972969385 0.9238245264812861 20.17096314420995 -6.660331715533692 1.9718785228249687 1.756667101194709 0.929057624733259 0.236973071338751 0.5006040481215309 0.4836399246368353 3.615469853230593 0.20509099668118783 0.5549072513144194 2.1860912425288631e-07 6.660331715533692 -0.82760947646145 VTNVDEEK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTNVDEEKQR 10 1 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 1 5326450.0 842450.0 1037400.0 3446600.0 True False 1278058.241344832 852267.8647568049 2765377.999301553 1.0 0.6668458738312343 2.163733944074172 20.285522150980622 -6.848302099100158 1.2432486221263699 0.8224427610641306 2.2216448094169556 0.9378003091937872 0.16003765611989845 0.15933358028378114 0.47477405402874523 0.10077014784458316 0.23295044586387037 1.4180707559105144e-07 6.848302099100158 1.3992020483528251 up VTNVDEEK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTNVDEEKQR 10 1 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 1 3909000.0 2010000.0 1899000.0 0.0 True False 2753151.318207593 1815095.9008467672 0.0 1.0 0.6592793824454458 0.0 21.392652474582142 -7.51381545809983 0.7098171049173766 0.9935229114991755 5.5221279942928186e-17 0.9870724300270205 0.0471961598468448 0.11949919096342347 0.14292008100785197 0.041804871026793256 0.07580927366837262 3.0632648101635405e-08 7.51381545809983 -0.9935229114991755 down VTNVDEEK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTNVDEEKQR 10 1 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 1 3973210.0 1219200.0 1812600.0 941410.0 True False 1013818.8197179075 1802835.1640270695 1138254.4784119618 1.0 1.778261686371835 1.1227395430760283 19.951368419644226 -10.189905205802672 4.376402468539 0.9998772031346637 1.4505006147382955 0.3864016441988928 0.26761579442886657 187941924.80210367 58.26059668540459 243078.12377178814 0.09161200458567162 6.457951724659215e-11 10.189905205802672 0.45062341160363184 VTNVDEEK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTNVDEEKQR 10 1 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 1 4220970.0 842450.0 739820.0 2638700.0 True False 1090568.1321721687 698648.366645954 2158483.6753483815 1.0 0.6406278947968176 1.9792286347567878 20.05664847307307 -6.8352393829303075 1.3042161930576295 0.8085491379620239 2.0192922464481975 0.9159686340528277 0.1639786583887852 0.17443652541954918 0.578393952896963 0.0986558183699371 0.22708811659354047 1.4613714451107424e-07 6.8352393829303075 1.2107431084861737 VTPQSDGSSSK(ub)VK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTPQSDGSSSKVK 13 1 P34932;A0A087WYC1 P34932 HSPA4 Heat shock 70 kDa protein 4 1 7367680.0 2111300.0 817780.0 4438600.0 True False 3202996.456705261 671840.7696556968 3561308.764492511 1.0 0.20975382855926758 1.1118678439487957 21.610990771465314 -6.675228564124614 1.9183875939785138 0.4979001399693831 1.10835848105812 0.3026753399256784 0.335275635785328 0.4491802738703653 3.191623091865404 0.14043895079528929 0.37273957123781165 2.1123770278304538e-07 6.675228564124614 0.6104583410887369 VTPQSDGSSSK(ub)VK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTPQSDGSSSKVK 13 1 P34932;A0A087WYC1 P34932 HSPA4 Heat shock 70 kDa protein 4 1 13290300.0 3311800.0 6751600.0 3226900.0 True False 4536261.958029797 6453291.987444475 2464772.6800916167 1.0 1.4226012622620428 0.5433488416004362 22.113072524118902 -6.77601371039079 1.5514545508270077 1.240526203411442 0.5372411286791549 0.7530174056535269 0.1784348360599595 0.25681596485713043 1.2206768477240553 0.09061345162496834 0.21452846712193546 1.6748900000175076e-07 6.77601371039079 -0.7032850747322871 VTPQSLFILFGVYGDVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTPQSLFILFGVYGDVQR 18 0 P26599;P26599-2;P26599-3;A0A0U1RRM4;A6NLN1;A0A0D9SF20 P26599 PTBP1 Polypyrimidine tract-binding protein 1 0 1060930000.0 388920000.0 303990000.0 368020000.0 False True 590020073.860564 249740609.41528898 295280685.6911038 1.0 0.4232747672146299 0.5004587111063035 29.136188798262243 -10.619739374266757 6.544659335253277 1.001746680941629 0.46186673916082716 0.9848055141016089 0.031510213145034445 0.0008051181158555791 4.677924854932025e-05 0.03058741513435581 0.010169877562180374 2.400272921705721e-11 10.619739374266757 -0.539879941780802 VTPVLYLNYGPYSSYAPHYDSTFANISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTPVLYLNYGPYSSYAPHYDSTFANISK 28 0 Q9NPI1-2;Q9NPI1 Q9NPI1-2 BRD7 Bromodomain-containing protein 7 0 14335500.0 7691900.0 6643600.0 0.0 False True 9957316.180016743 6273877.819806249 0.0 1.0 0.6300771921250471 0.0 23.24732551086055 -7.579601790987174 0.6851691546149906 0.9957229713990678 9.228647299100992e-21 0.9870907297712104 0.046905053875431535 0.12100751451597816 0.14568124804712243 0.04220752841525933 0.07686587527156656 2.6326808172827137e-08 7.579601790987174 -0.9957229713990678 down VTQDELK(ub)EVFEDAAEIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTQDELKEVFEDAAEIR 17 1 P19338;H7BY16 P19338 NCL Nucleolin 1 13570200.0 5398700.0 2297100.0 5874400.0 True False 5227321.2235989785 3214344.0092182504 4335718.411777528 1.0 0.6149122794878089 0.8294340879997446 22.317640386256176 -10.127726718366018 5.233459196861383 1.000007564278918 0.7221731837435391 0.6910120903746675 0.0875781615930444 7.729805936628596e-06 1.288162982052552e-06 0.08479949947775578 0.028265730111657294 7.452007471140938e-11 10.127726718366018 -0.2778343805353788 VTQDELK(ub)EVFEDAAEIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTQDELKEVFEDAAEIR 17 1 P19338;H7BY16 P19338 NCL Nucleolin 1 25321200.0 5291900.0 5894300.0 14135000.0 True False 6850468.868944029 5566277.023493881 11562575.03734772 1.0 0.8125395691859992 1.6878516286331275 22.707771303638378 -6.850682647024241 1.231733429863458 0.8998999639036956 1.7233178749334277 0.9412997436177151 0.09117180783596526 0.1567085510993528 0.45716443569032367 0.05790835956892669 0.1340679045287084 1.4103189875202983e-07 6.850682647024241 0.823417911029732 VTQPTGEEPALSNLGLPFSSFDHSK(ub)AHYYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTQPTGEEPALSNLGLPFSSFDHSKAHYYR 30 1 Q9BSM1-3;Q9BSM1 Q9BSM1-3 PCGF1 Polycomb group RING finger protein 1 1 28440100.0 7369800.0 6991300.0 14079000.0 True False 11180525.404550001 5743647.891723778 11296279.478955097 1.0 0.5137189607731991 1.010353187369709 23.414484650311085 -10.840015907069867 11.329590402368803 1.0036640119502078 0.7620360740714541 0.23437190720681145 0.20275007399386788 0.01888101041471844 0.0002666164437634844 0.19753204914455558 0.06543730500171431 1.4453868290409228e-11 10.840015907069867 -0.2416279378787537 VTQPTGEEPALSNLGLPFSSFDHSK(ub)AHYYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTQPTGEEPALSNLGLPFSSFDHSKAHYYR 30 1 Q9BSM1-3;Q9BSM1 Q9BSM1-3 PCGF1 Polycomb group RING finger protein 1 1 31727800.0 7369800.0 11112000.0 13246000.0 True False 9540351.38047653 10493607.431766953 10835363.915437404 1.0 1.0999183377292765 1.1357405490966506 23.185610972403534 -13.999999775354844 0.14281271650711946 0.5213883961167493 1.1786053318965486 0.9995919522297183 0.0011602498981230546 11.938098065846129 0.11860062255106636 1.5899415292125796 0.038398192745766536 1.0000005172647208e-14 13.999999775354844 0.6572169357797993 VTQQGLK(ub)MVVPGLDGAQIPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTQQGLKMVVPGLDGAQIPR 20 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 79331000.0 28350000.0 33497000.0 17484000.0 True False 27450044.768005453 46872526.784547396 12904415.891243082 1.0 1.7075573894575182 0.47010545885462063 24.710305166320946 -6.751609695000459 1.64376242234547 1.4152402370835833 0.46732080005295523 0.6559276848690633 0.2973476274196119 0.29724123824682597 1.580621481400412 0.14286618038650564 0.34627333334396615 1.7717004888332382e-07 6.751609695000459 -0.9479194370306281 VTQQGLK(ub)MVVPGLDGAQIPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTQQGLKMVVPGLDGAQIPR 20 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 70918000.0 27474000.0 15616000.0 27828000.0 True False 41680066.61844375 12829202.791635113 22327783.60255432 1.0 0.30780187827142513 0.5356945277211747 25.312854247730588 -10.134511117118887 5.189139109659564 1.0000185194796125 0.42174820299629967 0.8956642466544633 0.09303678454915794 2.0088130240628474e-05 3.3505276327955518e-06 0.09008538154941995 0.03002749309500752 7.336499341246422e-11 10.134511117118887 -0.5782703164833128 VTQQGLK(ub)MVVPGLDGAQIPR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VTQQGLKMVVPGLDGAQIPR 20 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 107025800.0 36994700.0 51198500.0 18832600.0 True False 30762732.19309229 50922683.518393464 22770409.58789592 1.0 1.6553368276510905 0.740194643472174 24.874680306210163 -6.714440197692788 1.7790341851126343 1.4010317122879472 0.7420155690877107 0.48635190541161055 0.27597059107057204 0.3662021683039801 2.2618520798984454 0.12331286786087044 0.31163767378488844 1.9300110802276548e-07 6.714440197692788 -0.6590161432002365 VTQQGLK(ub)MVVPGLDGAQIPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTQQGLKMVVPGLDGAQIPR 20 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 58995000.0 27474000.0 14726000.0 16795000.0 True False 35565634.593504876 13906485.154805623 13738482.331252554 1.0 0.39100905449175577 0.3862853141319043 25.083980569823037 VTQSNFAVGYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTQSNFAVGYK 11 0 P21796;C9JI87 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 0 31648300.0 10683000.0 11809000.0 9156300.0 False True 14005516.45431917 10047143.23112146 8208893.909431528 1.0 0.7173704207118342 0.5861186152046526 23.73949184807718 -13.999999999993168 0.102659338163481 2.3855537399519258 0.3177435891982713 0.9997803326816175 0.002559499874144515 12.060698937854687 0.09594604842381504 3.5173396934741805 0.23901697479214404 1.000000000015731e-14 13.999999999993168 -2.0678101507536546 VTQSNFAVGYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTQSNFAVGYK 11 0 P21796;C9JI87 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 0 11415330.0 4447900.0 953130.0 6014300.0 False True 4306703.849157366 1333719.7795072892 4438974.404867498 1.0 0.3096845815781459 1.0307127121675692 22.038152689272227 -10.10450414908359 14.568821245966602 1.0000472981470123 0.6701986096180409 0.21811363186736443 0.2943585029561497 0.0 0.0 0.28501139436859235 0.09500379812286411 7.861326807009044e-11 10.10450414908359 -0.3298486885289714 VTQSNFAVGYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTQSNFAVGYK 11 0 P21796;C9JI87 P21796 VDAC1 Voltage-dependent anion-selective channel protein 1 0 25838000.0 10683000.0 5243700.0 9911300.0 False True 14632793.79721976 5012015.995402952 7570455.069630921 1.0 0.3425194166513327 0.5173622463722076 23.80270190960007 -10.730760773290639 10.41365350913197 1.000895686270048 0.4299408315129266 0.9340964553968228 0.0713792863334115 0.001485986555532684 3.841923991144264e-05 0.06918936133913241 0.02303756560278945 1.8588280897315227e-11 10.730760773290639 -0.5709548547571214 VTSAHK(ub)GPDETLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTSAHKGPDETLR 13 1 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 13707600.0 1781000.0 6424800.0 5501800.0 True False 2334908.2472285326 5466244.883674249 4932526.512992197 1.0 2.341096225156822 2.1125140651016845 21.154934428094577 -10.232759481764674 5.486449709227212 0.9999242558544946 2.226805145129333 0.9746235052107313 0.09331827607332871 8.646412635621823e-05 1.2091048004168543e-05 0.09036052640603931 0.030118344094024835 5.851140386035367e-11 10.232759481764674 1.2268808892748386 VTSAHK(ub)GPDETLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTSAHKGPDETLR 13 1 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 24185500.0 5177200.0 5609400.0 13398900.0 True False 5012852.619856004 7849262.672634552 9889326.131616166 1.0 1.5658275373074952 1.972794111768688 22.25720038817843 -7.2127013349364475 0.10284535288401721 2.109422713862816e-09 3.4521848958590415 0.999999307291173 0.0003319531285947823 0.09530153961024108 0.004703370631825204 0.05824015297404523 0.09620903798254272 6.127716509780793e-08 7.2127013349364475 3.4521848937496187 VTSAHK(ub)GPDETLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTSAHKGPDETLR 13 1 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 48456700.0 9758900.0 16956800.0 21741000.0 True False 14804964.771155667 13930726.555916887 17443881.82058118 1.0 0.9409496592020234 1.1782454122799997 23.81957772179627 -6.840821974637116 1.2784656075900576 0.9685875083659831 1.18618299742221 0.9258681585897605 0.027463263944988756 0.16784701769435403 0.5325390305844755 0.01684123626219315 0.03881022333283895 1.4427066225322106e-07 6.840821974637116 0.21759548905622694 VTSAHK(ub)GPDETLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTSAHKGPDETLR 13 1 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 1 15448200.0 1781000.0 5522900.0 8144300.0 True False 2439483.8297152827 5278880.016212018 6220784.077123605 1.0 2.163933186156076 2.5500411199075854 21.21814448961747 -10.09523399535948 0.2630643687738322 1.588035180613466e-13 2.7384245581602915 0.999050099912128 0.02030526561971189 1.5647735948050063 0.12087786279854043 1.2951341237440808 0.16247819767286223 8.030933035606445e-11 10.09523399535948 2.7384245581601325 VTSEELHYFVQNHFTSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTSEELHYFVQNHFTSAR 18 0 P22695;H3BRG4;H3BSJ9 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 24929400.0 6445100.0 8929000.0 9555300.0 False True 8449588.514437184 7596828.004969388 8566609.216909798 1.0 0.899076681898681 1.0138492782545172 23.010449654785784 -11.801299921192795 11.754132627450986 0.9535335933143583 0.9608166825996398 0.0 0.05215239288585965 0.0 0.0 0.0 0.015305433111189494 1.5801564157328084e-12 11.801299921192795 0.007283089285281541 VTSEELHYFVQNHFTSAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTSEELHYFVQNHFTSAR 18 0 P22695;H3BRG4;H3BSJ9 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 27056300.0 7683800.0 2347500.0 17025000.0 False True 7439881.9748994745 3284868.9920507753 12565641.760947935 1.0 0.44152165358714035 1.6889571371349232 22.826848304155085 -6.785004604227308 1.5163894716622892 0.6858324519530256 1.7004325575280212 0.784703601592494 0.2367289226837856 0.24286898850863492 1.1032991599595836 0.12292246094383596 0.2888541490981587 1.640572380373912e-07 6.785004604227308 1.0146001055749956 VTSEELHYFVQNHFTSAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTSEELHYFVQNHFTSAR 18 0 P22695;H3BRG4;H3BSJ9 P22695 UQCRC2 Cytochrome b-c1 complex subunit 2, mitochondrial 0 27048500.0 6445100.0 8955400.0 11648000.0 False True 8828027.642278483 8559720.816452423 8896982.298090156 1.0 0.9696073872105807 1.007810879010102 23.073659716308676 -6.694755159672786 1.849550988945179 0.98103140578403 1.0076868638537062 0.3927722634685016 0.01284178350378022 0.4065171112892467 2.6997323465880974 0.00554702289700778 0.01435867023453754 2.0195045701931666e-07 6.694755159672786 0.026655458069676174 VTSSEPPNPASSSKSEK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTSSEPPNPASSSKSEK 17 1 Q92575 Q92575 UBXN4 UBX domain-containing protein 4 1 3051600.0 1596900.0 1454700.0 0.0 True False 2093551.3644016003 1237664.4303761865 0.0 1.0 0.591179395653351 0.0 20.99752088375224 -7.673805663716718 0.6547740863342317 0.9992115955090212 4.9614853320307624e-15 0.9873644400688941 0.046144020510200834 0.12065970529487377 0.14991139665023037 0.04266835905491995 0.07773093152994141 2.119309262769689e-08 7.673805663716718 -0.9992115955090162 down VTSVVFHPSQDLVFSASPDATIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTSVVFHPSQDLVFSASPDATIR 23 0 Q9UMS4 Q9UMS4 PRPF19 Pre-mRNA-processing factor 19 0 55702500.0 9332500.0 32697000.0 13673000.0 False True 14158084.797140049 26861964.887172945 10970525.55691121 1.0 1.8972880352149817 0.7748594329034723 23.755122785526314 -6.6938412362607735 1.8530090389777154 1.5605234370503138 0.7785802867633619 0.38830129248826684 0.3792018700656875 0.4084930438640727 2.722377866566439 0.16353978406704195 0.42378056899251687 2.0237588629631602e-07 6.6938412362607735 -0.7819431502869519 VTTEQYQK(ub)AAEEVEAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTTEQYQKAAEEVEAK 16 1 C9JRZ6;Q9NX63;F8WAR4 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 33561300.0 10835000.0 15491000.0 7235300.0 True False 14204789.92628927 13179803.183445064 6486660.561898365 1.0 0.9278421751984358 0.45665304418851627 23.759874159973997 -6.934070861984917 0.712582515147484 1.0061976654549403 0.34906350088073157 0.9972796213848646 0.012566563116476049 0.09057842419406045 0.06772375089932338 0.01173984667531844 0.04172139246144328 1.1639360994091128e-07 6.934070861984917 -0.6571341645742087 down VTTEQYQK(ub)AAEEVEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTTEQYQKAAEEVEAK 16 1 C9JRZ6;Q9NX63;F8WAR4 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 46542000.0 16208000.0 17202000.0 13132000.0 True False 15693485.91181066 24070848.307244938 9692335.248444522 1.0 1.533811445239812 0.6176024436451196 23.90366251040513 -6.748790970448288 1.6546070779001618 1.3143443041952523 0.6159791358606072 0.6436517974485576 0.22429734283632224 0.3021499244777347 1.6271963586353317 0.10710997009874475 0.26033568200388113 1.7832368476796808e-07 6.748790970448288 -0.6983651683346451 VTTEQYQK(ub)AAEEVEAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTTEQYQKAAEEVEAK 16 1 C9JRZ6;Q9NX63;F8WAR4 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 93042000.0 27351000.0 25719000.0 39972000.0 True False 41493466.6259392 21129243.506535817 32071516.679650012 1.0 0.5092185643830274 0.7729293136380379 25.30638085830049 -10.062126300253798 5.199683004434549 1.0000047682504227 0.6410739390097381 0.7118137209737492 0.10765946256307918 5.951039628622805e-06 1.0733709516648662e-06 0.10424221005156022 0.03474694213030426 8.667097850935309e-11 10.062126300253798 -0.35893082924068465 VTTEQYQK(ub)AAEEVEAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTTEQYQKAAEEVEAK 16 1 C9JRZ6;Q9NX63;F8WAR4 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 31932700.0 10835000.0 14424000.0 6673700.0 True False 14840992.304865317 13786699.98621052 5097509.509165891 1.0 0.928960793389188 0.34347497825295525 23.823084221496888 -6.929546602612898 0.7505095499008866 1.0090550144033608 0.22465593729779967 0.9964482712043097 0.01753193296193565 0.09287409334303645 0.07884001690498593 0.01592951872370219 0.05310914430768176 1.176124772101734e-07 6.929546602612898 -0.7843990771055611 down VTTEQYQK(ub)AAEEVEAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTTEQYQKAAEEVEAK 16 1 C9JRZ6;Q9NX63;F8WAR4 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 36237300.0 16208000.0 14523000.0 5506300.0 True False 13477670.13614491 14444761.716410207 6657641.871745347 1.0 1.071755100881399 0.4939757246239941 23.684067785839407 -6.875793842189996 1.1030413492808218 1.0424144738800112 0.45620140889686506 0.9701288964703727 0.04444028758461609 0.13141856826050147 0.29538655340212494 0.03114500371796265 0.07457154632611294 1.3310861291590935e-07 6.875793842189996 -0.5862130649831461 down VTTGTSNTTAIK(ub)SIEFAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTTGTSNTTAIKSIEFAR 18 1 Q15291-2;Q15291 Q15291-2 RBBP5 Retinoblastoma-binding protein 5 1 5343400.0 1084600.0 1500000.0 2758800.0 True False 901892.9559268721 1491919.2022733134 3335652.3247500183 1.0 1.6542087311681835 3.6985013607540385 19.782596687166112 -6.950530565101277 0.5529872232125882 0.9722158543967855 4.477025674988794 0.9992422713892846 0.03163798464696224 0.08327337488922233 0.03508591384147556 0.03420881410964335 0.16968922017210775 1.120648553520663e-07 6.950530565101277 3.5048098205920084 VTTHPLAKDK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTTHPLAKDK 10 1 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 1 3248260.0 772960.0 1604200.0 871100.0 True False 1013358.0453552871 1364859.6131226227 780966.9281812308 1.0 1.346868088114007 0.7706722532680153 19.95071257465031 -6.743697060198072 1.6731272259033154 1.2054966303189494 0.7700525239727491 0.6214301017523489 0.14573333736539623 0.3111710583113919 1.7117061044532005 0.06886788511425572 0.1683168563236958 1.8042758650261057e-07 6.743697060198072 -0.43544410634620023 VTTHPLAKDK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTTHPLAKDK 10 1 Q99497;K7ELW0;K7EN27 Q99497 PARK7 Protein deglycase DJ-1 1 3024760.0 772960.0 1246100.0 1005700.0 True False 1058744.2004585764 1191043.181698347 768174.3730416629 1.0 1.1249583999444508 0.7255523786661042 20.013922636173202 -6.822647396665588 1.3605599859040436 1.0671757910819646 0.7163404926827762 0.8903280805748937 0.05524548023807967 0.19006344018554872 0.6906223483328415 0.03190382538935323 0.07347986980056738 1.50436286137693e-07 6.822647396665588 -0.35083529839918837 VTVAGGVHISGLHTESAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTVAGGVHISGLHTESAPR 19 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 44190600.0 16689500.0 11090900.0 16410200.0 False True 21880096.121347908 9436180.951989591 14712229.921753693 1.0 0.4312678015515172 0.6724024355358891 24.383115740252762 -10.321411428909368 5.778472515027345 1.0000537319268488 0.5518351185437066 0.8216099943887543 0.0984428020957562 6.81526890903377e-05 8.00334608674071e-06 0.09532821269107793 0.03177227775590366 4.770771004821383e-11 10.321411428909368 -0.4482186133831422 VTVAGGVHISGLHTESAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTVAGGVHISGLHTESAPR 19 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 14979300.0 3455700.0 2656700.0 8866900.0 False True 3346000.6950545413 3717534.164507473 6544392.888701863 1.0 1.1110380730052045 1.9558850954139404 21.67400631438712 -6.931041579678308 0.7381913780658296 0.9876365233163622 2.134020480610554 0.9967390838515834 0.024375055514064204 0.09210035971710706 0.07505656141230527 0.022346131450886722 0.07601080244416995 1.1720831440598545e-07 6.931041579678308 1.1463839572941918 VTVAGGVHISGLHTESAPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTVAGGVHISGLHTESAPR 19 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 66768800.0 3711800.0 25537000.0 37520000.0 False True 5631071.968928424 20979722.828508288 30104155.55439981 1.0 3.725706747182751 5.346078991799592 22.424978158955483 -8.470826981808354 0.2826462887737446 1.8888310299340475e-17 6.341837604499128 0.9989821873063729 0.05721212695474746 0.15921124940836495 0.07679266170284585 0.6536984941638462 0.5498662004259764 3.381995443861824e-09 8.470826981808354 6.341837604499128 VTVAGGVHISGLHTESAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTVAGGVHISGLHTESAPR 19 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 37389800.0 16689500.0 9762400.0 10937900.0 False True 22860059.166778915 9331064.8880603 8354593.293121613 1.0 0.4081820095033065 0.36546682719276674 24.446325801775654 -13.999999999999998 0.37310599274181 9.406294420482697 0.3612524124868042 0.9997961696383169 0.004134295433481144 23.187126468947074 0.19854764343905654 156.10767210399345 0.011823238554780723 1.0000000000000041e-14 13.999999999999998 -9.045042007995892 VTVAGGVHISGLHTESAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTVAGGVHISGLHTESAPR 19 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 12188100.0 3455700.0 2761500.0 5970900.0 False True 2873567.6634671697 2746623.2513851686 7219387.583677658 1.0 0.9558234129316331 2.5123429928101775 21.454411589821397 -6.900366515603552 0.9589296127169604 0.9359348121964601 2.6769581055251837 0.9867482985762206 0.08329366219797768 0.11113661714730176 0.1758943343762698 0.06510001124300895 0.16969612880247678 1.2578634108270536e-07 6.900366515603552 1.7410232933287235 up VTVAGLAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTVAGLAGK 9 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 16257400.0 3116700.0 6532600.0 6608100.0 False True 4086023.882165734 5557961.543875366 5924357.201371133 1.0 1.3602371655570096 1.4499076295733786 21.962266205745138 -12.35842438652991 0.2213075595822233 4.814711612187008e-08 1.5010017515157168 0.9994006621855471 0.0047599194136979574 6.20039138259809 0.13789858797307702 2.8268930676804382 0.04908868102425908 4.3810238098051187e-13 12.35842438652991 1.5010017033686007 VTVAGLAGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTVAGLAGK 9 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 13687100.0 3797500.0 1332700.0 8556900.0 False True 3676950.441146401 1864854.059938689 6315591.188502508 1.0 0.5071741079429029 1.7176166199654925 21.810078300993435 -6.796149339585824 1.4714525632716056 0.7267501688458681 1.7328061462951876 0.8207199377262269 0.21043434736624203 0.22628956558547136 0.9676230927389011 0.1125260382085492 0.26234675425648823 1.599008087786208e-07 6.796149339585824 1.0060559774493196 VTVAGLAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTVAGLAGK 9 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 16439700.0 3116700.0 6885000.0 6438000.0 False True 4269028.215650548 6580797.934349663 4917476.99477202 1.0 1.5415213022542247 1.151896109925958 22.02547626726803 -10.237248199780376 9.379319112622385 0.9999999774033856 1.3467087060900913 0.5135670526729101 0.15906381868966876 8.070426541608232e-08 6.606473115634871e-09 0.15401289166712284 0.051337626730770254 5.790976468877706e-11 10.237248199780376 0.34670872868670566 VTVAGLAGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTVAGLAGK 9 0 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 5988060.0 3797500.0 762460.0 1428100.0 False True 3157789.507774568 758352.4766435398 1726709.1072116503 1.0 0.2401529534430507 0.546809438362007 21.59048357642771 -10.486276225986963 6.176128800723585 1.0004073991079336 0.3934811959073786 0.8391202966656066 0.12519198572782142 0.000702735134781471 5.845258750981126e-05 0.12129394340362203 0.040405539650207385 3.263801773041439e-11 10.486276225986963 -0.606926203200555 VTVAGLAGKDPVQCSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTVAGLAGKDPVQCSR 16 1 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 44331500.0 7614500.0 18289000.0 18428000.0 False True 9982683.238922881 15560352.489963634 16521247.333858019 1.0 1.5587344722402088 1.6549906411375466 23.250996218071712 -11.554375651669524 0.3012103828802162 5.805773924356563e-23 1.6814817186691853 0.999391019483404 0.007125981871743895 4.037083039227424 0.16114350068281455 2.645345524555987 0.034539473349758286 2.7901294191259635e-12 11.554375651669524 1.6814817186691853 VTVAGLAGKDPVQCSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTVAGLAGKDPVQCSR 16 1 Q99497;K7ELW0 Q99497 PARK7 Protein deglycase DJ-1 0 53508500.0 7614500.0 26135000.0 19759000.0 False True 10429786.424125217 24980269.283112302 15092331.149378726 1.0 2.3950892441412086 1.447041246642265 23.314206279594604 -10.428206496742225 5.790389734423792 0.9995498231464184 1.9210652453917378 0.5572314625358865 0.38703897425663564 0.00225031748934571 0.00022221588421029423 0.37491840359528367 0.12491629180242862 3.7307272836919127e-11 10.428206496742225 0.9215154222453195 VTVFDLK(ub)NNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTVFDLKNNK 10 1 Q15269;A0A0B4J2E5;C9J544 Q15269 PWP2 Periodic tryptophan protein 2 homolog 1 4857900.0 1432600.0 1884500.0 1540800.0 True False 1962270.9345593036 1801236.558791859 1176894.7737720935 1.0 0.9179346883596324 0.5997616093908084 20.90409282034074 -6.9455931908214525 0.6053054538708255 1.0035460717448719 0.4977140630211339 0.9988083976986084 0.00595855396668107 0.08530530624749541 0.043670160518854736 0.006083956758386413 0.026785622378311398 1.133461594050771e-07 6.9455931908214525 -0.505832008723738 VTVITK(ub)HNDDEQYAWESSAGGSFTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTVITKHNDDEQYAWESSAGGSFTVR 26 1 P07900;P07900-2;Q14568 P07900 HSP90AA1;HSP90AA2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 71100700.0 9391700.0 20722000.0 40987000.0 True False 14247895.525239795 17023997.19827501 32885901.484759726 1.0 1.1948429273724965 2.3081234296323383 23.76424550703188 -6.936878977507495 0.6879927701537855 0.9865757137865796 2.582637655825319 0.9977257773564021 0.027480527405755895 0.08921984613628713 0.06131404290981664 0.02615537943879152 0.09720837209399828 1.1564344546252921e-07 6.936878977507495 1.5960619420387394 up VTVITK(ub)HNDDEQYAWESSAGGSFTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTVITKHNDDEQYAWESSAGGSFTVR 26 1 P07900;P07900-2;Q14568 P07900 HSP90AA1;HSP90AA2P Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2 1 46908700.0 9391700.0 17081000.0 20436000.0 True False 12157740.788083997 16130427.334594263 16716857.69106739 1.0 1.3267619055017164 1.374997047761691 23.53537182912433 -12.384317990486219 0.2971894510062388 2.4435679315941585e-07 1.3880014275061383 0.9995203011069991 0.0036483090535722193 6.486998118600936 0.16651136741498332 3.9545261098209723 0.01764026429333453 4.1274517923978065e-13 12.384317990486219 1.388001183149345 VTVLFAGQHIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTVLFAGQHIAK 12 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98 P21333-2 FLNA Filamin-A 0 54965000.0 15581000.0 19400000.0 19984000.0 False True 20426841.886618614 16505595.620607713 17916247.380063973 1.0 0.8080346297398198 0.8770933597817046 24.283962836138606 -10.668926027703751 9.194751353415251 1.0001422201736956 0.84256399557501 0.8738906146407353 0.028193108481204893 8.226863731252494e-05 2.9622316645719817e-06 0.02732227234682969 0.00909928663546047 2.1432556254191002e-11 10.668926027703751 -0.15757822459868553 VTVLFAGQHIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTVLFAGQHIAK 12 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98 P21333-2 FLNA Filamin-A 0 38387900.0 16534000.0 5484900.0 16369000.0 False True 16009137.22025402 7675049.173375636 12081467.840526083 1.0 0.47941678978586794 0.7546607711776727 23.932392223058752 -10.037447085350339 5.1529589596199825 1.0000041991281798 0.6170387804803508 0.7207598241366346 0.11236788486862842 5.420709727417603e-06 1.0127954920808519e-06 0.10880092802649542 0.03626657889468341 9.173877035420654e-11 10.037447085350339 -0.38296541864782907 VTVLFAGQHIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTVLFAGQHIAK 12 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98 P21333-2 FLNA Filamin-A 0 22762400.0 22762400.0 0.0 0.0 False True 34532224.95434461 0.0 0.0 1.0 0.0 0.0 25.041439956039298 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 VTVLFAGQHIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTVLFAGQHIAK 12 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98 P21333-2 FLNA Filamin-A 0 41723400.0 15581000.0 9163400.0 16979000.0 False True 21341716.76069276 8758530.688688414 12968909.893481525 1.0 0.41039485187151875 0.6076788497806185 24.347172897661498 -10.048859153079782 5.592464427533603 1.0000023541142924 0.5090368508258761 0.8919804131252475 0.0805408548829642 2.3639777740050977e-06 4.020720440376847e-07 0.07798372035534479 0.025994449137484298 8.935952404214573e-11 10.048859153079782 -0.49096550328841626 VTVLFAGQHIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTVLFAGQHIAK 12 0 P21333-2;P21333;Q60FE5;A0A087WWY3;F8WE98 P21333-2 FLNA Filamin-A 0 27050100.0 16534000.0 6105600.0 4410500.0 False True 13748753.580393614 6072707.920933288 5332715.158152078 1.0 0.44169152392063105 0.3878689895029312 23.71279749849303 -13.999999999999998 0.33080067390248424 7.1069615191010005 0.37842617453209737 0.9997165014989369 0.004659732189053532 18.891099846317363 0.183962050875474 80.29873396092766 0.017196147681459464 1.0000000000000041e-14 13.999999999999998 -6.728535344568903 VTVLFAGQHISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTVLFAGQHISK 12 0 O75369-2;O75369-9;O75369;O75369-8;O75369-6;O75369-3;E7EN95;O75369-7;O75369-5;O75369-4 O75369-2 FLNB Filamin-B 0 9340200.0 0.0 9340200.0 0.0 False True 0.0 7946678.567814446 0.0 0.0 VTVLGHVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTVLGHVQR 9 0 A0A2R8Y891;P08237;P08237-3;P17858;P17858-2 A0A2R8Y891;P17858 PFKM;PFKL ATP-dependent 6-phosphofructokinase, muscle type;ATP-dependent 6-phosphofructokinase, liver type 0 4992000.0 1175800.0 1541300.0 2274900.0 False True 1541485.1864633975 1311344.047940344 2039515.1703816797 1.0 0.8507016865656282 1.3230845085582066 20.555889594663856 -6.821719829626222 1.3642716852239376 0.9196610170751204 1.3337932659185938 0.8883005604332703 0.06589098657381533 0.191273263404954 0.6990339386649327 0.03794695826028218 0.0874303522169875 1.5075793162743123e-07 6.821719829626222 0.41413224884347344 VTVLGHVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTVLGHVQR 9 0 A0A2R8Y891;P08237;P08237-3;P17858;P17858-2 A0A2R8Y891;P17858 PFKM;PFKL ATP-dependent 6-phosphofructokinase, muscle type;ATP-dependent 6-phosphofructokinase, liver type 0 3550060.0 1175800.0 884060.0 1490200.0 False True 1610525.0348002424 844999.3060045263 1138245.4516323807 1.0 0.5246731890195881 0.706754273939964 20.619099656186748 -10.10279945685584 5.155857994253678 1.0000090952841902 0.6157137314791281 0.8558885707964292 0.07433429164680759 7.771726118123556e-06 1.35236750371641e-06 0.07197557068237152 0.02399128946635958 7.892244718216141e-11 10.10279945685584 -0.38429536380506213 VTVLGHVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTVLGHVQR 9 0 A0A2R8Y891;P08237;P08237-3;P17858;P17858-2 A0A2R8Y891;P17858 PFKM;PFKL ATP-dependent 6-phosphofructokinase, muscle type;ATP-dependent 6-phosphofructokinase, liver type 0 2743930.0 795060.0 1418800.0 530070.0 False True 661127.6171300197 1411156.6427902498 640905.1862332338 1.0 2.134469361476888 0.9694122127516435 19.334569255746008 -6.652225871949326 2.000402983817061 1.734849304369349 0.9742898498704786 0.2032082104254287 0.4839381133632376 0.5030940606484581 3.8612739733883195 0.19601942568109526 0.5361541463342142 2.227276465143252e-07 6.652225871949326 -0.7605594544988703 VTVLTHCNTGALATAGYGTALGVIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTVLTHCNTGALATAGYGTALGVIR 25 0 Q9BV20 Q9BV20 MRI1 Methylthioribose-1-phosphate isomerase 0 8330900.0 2087900.0 3998000.0 2245000.0 False True 2737257.1192523595 3401513.9840819403 2012708.9355606276 1.0 1.2426724402897937 0.7353013794006932 21.384299527318145 -6.776645113518845 1.548968931196545 1.1380053404940602 0.7316983645813876 0.755338724716095 0.10248706496831266 0.2558174634065288 1.21209011915195 0.05212602071644785 0.12334355868398748 1.6724567146522574e-07 6.776645113518845 -0.4063069759126726 VTVNTNMVDLNDYLQHILK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VTVNTNMVDLNDYLQHILK 19 0 P53618 P53618 COPB1 Coatomer subunit beta 0 241789300.0 109715300.0 51460000.0 80614000.0 False True 106232447.85661885 72008246.36035493 59498775.03183876 1.0 0.6778366479660144 0.5600809943883042 26.66264925228307 -13.999999999999998 0.13994627120162154 2.5388457774656183 0.41425783462315663 0.9996031473828655 0.003704262172175389 11.933968008924788 0.11720339910862684 5.015178433904531 0.13035956078572034 1.0000000000000041e-14 13.999999999999998 -2.124587942842462 VTVNTNMVDLNDYLQHILK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VTVNTNMVDLNDYLQHILK 19 0 P53618 P53618 COPB1 Coatomer subunit beta 0 242313200.0 81219800.0 83665400.0 77428000.0 False True 123216374.56273833 68734655.68924613 62124321.86210206 1.0 0.5578370239602235 0.5041888473229675 26.87661875158215 -13.999999999999998 0.297527614755297 4.976493869698598 0.4906475444650722 0.9996443091331382 0.0041899733659732236 16.429184427448956 0.1731609533310399 40.161660986256045 0.019596580754099435 1.0000000000000041e-14 13.999999999999998 -4.485846325233526 VTVNTNMVDLNDYLQHILK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VTVNTNMVDLNDYLQHILK 19 0 P53618 P53618 COPB1 Coatomer subunit beta 0 225806900.0 109715300.0 34576600.0 81515000.0 False True 91233133.16190635 34390328.99288224 98559409.61722423 1.0 0.37694999394410406 1.0803028044900786 26.443054527717347 -6.672902785899732 1.9267943158058045 0.6033173691011282 1.0775184431861509 0.29212126507948544 0.26448029378810795 0.45446950245839973 3.2554554740362427 0.11038998128266819 0.2938534631744304 2.1237197901751412e-07 6.672902785899732 0.47420107408502266 VTVNTNMVDLNDYLQHILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTVNTNMVDLNDYLQHILK 19 0 P53618 P53618 COPB1 Coatomer subunit beta 0 101197000.0 53144000.0 31534000.0 16519000.0 False True 68795955.62485342 29779105.179386176 13512711.499253392 1.0 0.43286127663917634 0.1964172366895904 26.035820418507047 -10.290518828793456 0.20109627107556985 1.7193016732770618 9.217944001736132e-09 0.9993930586841092 0.008307166613701749 1.9127475035387569 0.09832117464596225 0.8530137697741572 0.14090998265632967 5.122490612767269e-11 10.290518828793456 -1.7193016640591179 VTVSPYTEIHLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTVSPYTEIHLK 12 0 Q13287 Q13287 NMI N-myc-interactor 0 10526000.0 4296100.0 2856700.0 3373200.0 False True 5632228.703491582 2430491.4953293824 3024173.6220192052 1.0 0.43153281290275913 0.536940841934283 22.425274486874322 -9.924241088448843 5.744125100337164 1.0000003413159313 0.4842368274182866 0.969625303999209 0.04303264765514822 1.8805983868628645e-07 3.523693263492987e-08 0.04166620924469403 0.013888727309028443 1.1905809013361562e-10 9.924241088448843 -0.5157635138976446 VTVSPYTEIHLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTVSPYTEIHLK 12 0 Q13287 Q13287 NMI N-myc-interactor 0 7952500.0 2127400.0 1310100.0 4515000.0 False True 2059866.8514798875 1833229.7620812443 3332386.052903367 1.0 0.8899748839417371 1.617767697222397 20.97411965483077 -6.868374696114102 1.142579150742337 0.9383383027522075 1.6591090267645396 0.96303816747362 0.061582351131170825 0.1384270509923804 0.3387568764117057 0.04186682866005555 0.0988570329609062 1.3540207002434635e-07 6.868374696114102 0.7207707240123321 VTVSPYTEIHLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTVSPYTEIHLK 12 0 Q13287 Q13287 NMI N-myc-interactor 0 12073600.0 2681800.0 5903800.0 3488000.0 False True 4068486.66584197 4850220.763400059 2798595.2711552917 1.0 1.1921437039775353 0.6878713145729641 21.95606083170603 -6.803448784807166 1.4418633004349912 1.1055549539427796 0.6803088690099899 0.8420341757693244 0.0825906340302472 0.2158729284711524 0.8856445738603076 0.0450556862291142 0.10456721551652644 1.5723572054321595e-07 6.803448784807166 -0.4252460849327897 VTVSPYTEIHLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTVSPYTEIHLK 12 0 Q13287 Q13287 NMI N-myc-interactor 0 10031600.0 4296100.0 2580800.0 3154700.0 False True 5884484.267737133 2466771.7224356704 2409624.833085944 1.0 0.4191993062094229 0.40948785372699453 22.488484548397214 VTVSPYTEIHLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTVSPYTEIHLK 12 0 Q13287 Q13287 NMI N-myc-interactor 0 4799100.0 2127400.0 1421300.0 1250400.0 False True 1769027.3597997716 1413643.1747940392 1511852.8588036199 1.0 0.7991075813287836 0.8546237854539117 20.754524930265045 -10.411595485006497 8.77712384865918 1.0000011854516784 0.8268656833913477 0.9284066402855993 0.02266439542712642 5.257364086604948e-07 3.524477498295225e-08 0.02194485659227178 0.007314902170093345 3.876185164221441e-11 10.411595485006497 -0.17313550206033068 VTVSPYTEIHLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTVSPYTEIHLK 12 0 Q13287 Q13287 NMI N-myc-interactor 0 13302500.0 2681800.0 6701800.0 3918900.0 False True 3471642.966181162 6328838.938644334 3205700.4113096534 1.0 1.823009739278032 0.9233957646387677 21.72718715379848 -6.666056765142219 1.9515509674210294 1.5270936590121664 0.9271010357080157 0.26166557921759537 0.3499171035185384 0.4702026844748743 3.448626095116392 0.14455227124766218 0.38817606450428144 2.1574623962122886e-07 6.666056765142219 -0.5999926233041507 VTWDSSFCAVNPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTWDSSFCAVNPR 13 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;F8W1H8;F8VUX3;F8VSA4;F8VRE9;F8VTT6;F8VVB7 Q9ULV4 CORO1C Coronin-1C;Coronin 0 18421100.0 5059000.0 5729400.0 7632700.0 False True 6632397.991425686 4874595.853026285 6842941.422028333 1.0 0.7349673314731905 1.0317446918708493 22.66109915080023 -6.671261044879182 1.9332179136916463 0.8310081452674272 1.0305424492568402 0.2844591177082155 0.11254869038424661 0.458259560748709 3.3031548233991197 0.046852300381704313 0.12495777220472686 2.1317631719269982e-07 6.671261044879182 0.19953430398941308 VTWDSSFCAVNPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTWDSSFCAVNPR 13 0 Q9ULV4;Q9ULV4-2;Q9ULV4-3;F8W1H8;F8VUX3;F8VSA4;F8VRE9;F8VTT6;F8VVB7 Q9ULV4 CORO1C Coronin-1C;Coronin 0 16069900.0 5059000.0 4201900.0 6809000.0 False True 6929449.014334427 4016246.1641748543 5200854.435756863 1.0 0.57959098275588 0.7505437192767057 22.72430921232312 -10.146011792135809 5.263299034959281 1.0000107191950605 0.6650673510160946 0.8365483027793901 0.06979116243543942 8.778826177330573e-06 1.424237102351562e-06 0.06757716425539165 0.022525000818642872 7.144769260516152e-11 10.146011792135809 -0.33494336817896586 VTWLAETTHALPIPVICVTYEHLITKPVLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTWLAETTHALPIPVICVTYEHLITKPVLGK 31 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 601620000.0 205338000.0 198370000.0 197912000.0 False True 311512758.21860677 162969323.62811574 158794606.45208892 1.0 0.5231545717743946 0.5097531393582713 28.214716010122782 VTWLAETTHALPIPVICVTYEHLITKPVLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTWLAETTHALPIPVICVTYEHLITKPVLGK 31 1 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 433405000.0 205338000.0 164183000.0 63884000.0 False True 265814088.8171036 155046071.7215439 52257767.50519424 1.0 0.5832876369025914 0.19659517574010454 27.98584233221523 -7.7329024857193005 0.3501549158182697 1.070321985553112 7.321840890801409e-23 0.998972897287525 0.010513969673433383 0.11992093949840119 0.05442967722484447 0.03272267930468958 0.07792693926759134 1.8496838909961058e-08 7.7329024857193005 -1.070321985553112 down VTWLAETTHALPIPVICVTYEHLITKPVLGKDEDFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTWLAETTHALPIPVICVTYEHLITKPVLGKDEDFK 36 2 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 240620000.0 71824000.0 66424000.0 102372000.0 False True 108962259.03774858 54570118.22691924 82138129.32875848 1.0 0.5008166929433256 0.7538218283479492 26.69925327825143 -10.268942111998184 4.894769593599508 1.0000983950636226 0.6273192606453171 0.7431311212114345 0.10328891400870815 0.00011093755932085425 1.6569102122073368e-05 0.10003534048166038 0.03333635365012804 5.383415343809473e-11 10.268942111998184 -0.37277913441830557 VTWLAETTHALPIPVICVTYEHLITKPVLGKDEDFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTWLAETTHALPIPVICVTYEHLITKPVLGKDEDFK 36 2 P07814;V9GYZ6 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 177339100.0 71824000.0 59508100.0 46007000.0 False True 92977583.86270273 56196421.92317595 37634198.071684234 1.0 0.6044082841102815 0.40476635881673967 26.47037960034388 -11.850208790125203 0.11143661059029117 2.2431842279108696 8.735156515530684e-23 0.9998124894325144 0.0033871147587241626 5.181653806538743 0.07801210593530213 1.8318074719874096 0.29742936556375416 1.4118586204800943e-12 11.850208790125203 -2.2431842279108696 VTYK(ub)YYVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VTYKYYVGR 9 1 Q5JVF3-3;Q5JVF3-2;Q5JVF3;Q5JVF3-4 Q5JVF3-3 PCID2 PCI domain-containing protein 2 1 5007360.0 1692000.0 795060.0 2520300.0 True False 2218228.385351308 676440.1471196064 2259523.5324247004 1.0 0.30494612348605227 1.0186162738454239 21.08097648011291 -10.941428965860421 12.840206072299791 1.059859570696878 0.6617811987030414 0.23044971150701277 0.2913546188393015 0.14238401251793145 0.0006494883599717843 0.08045243827360096 0.09403429888376871 1.1443820420984793e-11 10.941428965860421 -0.39807837199383667 VTYK(ub)YYVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTYKYYVGR 9 1 Q5JVF3-3;Q5JVF3-2;Q5JVF3;Q5JVF3-4 Q5JVF3-3 PCID2 PCI domain-containing protein 2 1 13472500.0 3131100.0 4026400.0 6315000.0 True False 3031704.9443774894 5634162.517398621 4660912.054060861 1.0 1.8584138696767218 1.5373897326996977 21.531697921778832 -10.070703839200586 4.922616026592812 0.9999814123054254 1.6979018011934897 0.8630440341416165 0.13105755513676495 2.6735933322895295e-05 5.047662872005113e-06 0.12689930728679696 0.042298644034006815 8.497597587933894e-11 10.070703839200586 0.6979203888880643 VTYK(ub)YYVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VTYKYYVGR 9 1 Q5JVF3-3;Q5JVF3-2;Q5JVF3;Q5JVF3-4 Q5JVF3-3 PCID2 PCI domain-containing protein 2 1 5359140.0 1692000.0 832840.0 2834300.0 True False 2317578.124580719 796042.3749664162 2164896.71424081 1.0 0.3434802764676729 0.934120274643371 21.1441865416358 -10.602522212378345 9.332767032520216 1.0000704984904658 0.6388002755555364 0.3327287160962562 0.24112776953480794 0.00035377186241526947 1.5066927225741235e-05 0.2335159924858866 0.07782365297637094 2.4973406571740063e-11 10.602522212378345 -0.3612702229349294 VTYK(ub)YYVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTYKYYVGR 9 1 Q5JVF3-3;Q5JVF3-2;Q5JVF3;Q5JVF3-4 Q5JVF3-3 PCID2 PCI domain-containing protein 2 1 11365600.0 3131100.0 6753200.0 1481300.0 True False 2603648.381248971 6716819.171194747 1791032.981242645 1.0 2.579771992089303 0.6878935704764735 21.31210319721311 -6.685139292244817 1.8831248157467 1.9949336714676424 0.694716554456292 0.3477574665505383 0.6688159214966577 0.42735802395175293 2.9341308044542536 0.2844953351537526 0.745571065338319 2.064717828013928e-07 6.685139292244817 -1.3002171170113503 VTYTPMAPGSYLISIK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VTYTPMAPGSYLISIK 16 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 28347200.0 8005600.0 11361000.0 8980600.0 False True 10495419.126340672 9665983.084831148 8051373.659998124 1.0 0.9209716132795628 0.7671321710050957 23.323256444888244 -6.96057039338221 0.4273199056573996 1.0062873105741859 0.6759430113557616 0.9997907669912361 0.0013985888844381766 0.07949801386459283 0.02038316646129458 0.0020011041002681233 0.012781584774059801 1.0950390496580185e-07 6.96057039338221 -0.33034429921842423 VTYTPMAPGSYLISIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VTYTPMAPGSYLISIK 16 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 30738100.0 11078000.0 7321100.0 12339000.0 False True 10726334.953790618 10244453.409032146 9107045.737934593 1.0 0.9550749117164034 0.8490361131894564 23.354653874767312 -6.956681962202741 0.47992342485684125 1.0025470670829768 0.7971435513253919 0.9996266209935666 0.001222973546303959 0.0809085043715704 0.02567862404409832 0.0014948836019707298 0.00874731551448045 1.1048874428306264e-07 6.956681962202741 -0.20540351575758486 VTYTPMAPGSYLISIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VTYTPMAPGSYLISIK 16 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 23102100.0 5065500.0 8770200.0 9266400.0 False True 7684733.837654764 7205089.288114648 7434891.978392598 1.0 0.9375847544400453 0.9674885474838498 22.87356386206452 -10.130485720919284 4.211751354909248 1.0000096273025376 0.9525366509561276 0.770586667924642 0.012208172415913461 1.184635163732759e-06 2.4454976589400103e-07 0.011823085147955707 0.003940170700662501 7.404816131963471e-11 10.130485720919284 -0.04747297634641001 VTYTPMAPGSYLISIK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VTYTPMAPGSYLISIK 16 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 37989900.0 8005600.0 10973000.0 19011300.0 False True 10965486.663205314 10488176.57714144 14521222.490013886 1.0 0.9564716003289221 1.3242661211508142 23.386466506411136 -6.877377086642666 1.0943707796774003 0.9738557007561491 1.3490503296080292 0.9715052678412522 0.02769823621925327 0.12997656048589665 0.2865687430256921 0.019541075991924048 0.04695423915416765 1.326242415741755e-07 6.877377086642666 0.37519462885188004 VTYTPMAPGSYLISIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VTYTPMAPGSYLISIK 16 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 22236700.0 11078000.0 4794500.0 6364200.0 False True 9211847.838611376 4768671.076866268 7694924.79526392 1.0 0.5176671565153765 0.8353291250655176 23.135059150201588 -10.109585524414575 7.309755651719291 1.000000100268481 0.6764981407904485 0.580327058608702 0.12968495560598056 2.1201049347444914e-07 2.5725203420143366e-08 0.1255669566859521 0.041855639442967586 7.769882935649704e-11 10.109585524414575 -0.3235019594780326 VTYTPMAPGSYLISIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VTYTPMAPGSYLISIK 16 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 23807600.0 5065500.0 11754000.0 6988100.0 False True 6557389.6059328485 11099879.567403609 5716337.503961051 1.0 1.6927283926153949 0.8717398000553682 22.644690184156968 -6.683043915477485 1.8913897446556738 1.4370989294454322 0.8748093823219705 0.3380060738172602 0.29340182181156244 0.43177426938173236 2.988997475903616 0.12436463887825105 0.32669179656916564 2.074703714625762e-07 6.683043915477485 -0.5622895471234617 VVAK(ub)LPFTPLSYIQGLSHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVAKLPFTPLSYIQGLSHR 19 1 Q9UM00-1;Q9UM00-2;Q9UM00;J3QQY2;J3KS45 Q9UM00-1 TMCO1 Transmembrane and coiled-coil domain-containing protein 1 1 27820100.0 1497400.0 3035800.0 23286900.0 True False 1449865.8566353195 4248010.771487862 17187362.29797465 1.0 2.9299336569978633 11.854449995712766 20.46748799582684 -6.941562543863852 0.6448697094071543 0.9019005155478595 14.375868721026018 0.9983613999997785 0.19138997836658977 0.08706116700007566 0.051418685778438306 0.1885870949895463 0.7629840273633974 1.14403011323792e-07 6.941562543863852 13.473968205478158 VVAK(ub)LPFTPLSYIQGLSHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVAKLPFTPLSYIQGLSHR 19 1 Q9UM00-1;Q9UM00-2;Q9UM00;J3QQY2;J3KS45 Q9UM00-1 TMCO1 Transmembrane and coiled-coil domain-containing protein 1 1 87065200.0 5198600.0 52888600.0 28978000.0 True False 7886656.268568151 43450216.10948211 23250485.598491423 1.0 5.5093330595186 2.9480789838850967 22.910982335059664 -9.766684740906294 7.77746414943056 1.0000000591435523 4.228706021701854 0.6793640859697967 1.0456275978210037 1.5446696644094238e-08 3.879491176259444e-09 1.0124245681738926 0.3374748560579641 1.7112570844813232e-10 9.766684740906294 3.228705962558302 VVAK(ub)LPFTPLSYIQGLSHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVAKLPFTPLSYIQGLSHR 19 1 Q9UM00-1;Q9UM00-2;Q9UM00;J3QQY2;J3KS45 Q9UM00-1 TMCO1 Transmembrane and coiled-coil domain-containing protein 1 1 32021200.0 1497400.0 3844700.0 26679100.0 True False 1245154.446067582 3823987.8379867994 32257576.459778965 1.0 3.0710951963137023 25.90648618864439 20.247893271261116 -6.924651499631139 0.7894527207047332 0.5754915866713654 30.01409830269011 0.9953786896664945 0.7671288551171251 0.09551153506112477 0.09199124370805747 0.6778038708185589 2.1301906916932634 1.189456325892138e-07 6.924651499631139 29.438606716018743 VVAK(ub)LPFTPLSYIQGLSHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVAKLPFTPLSYIQGLSHR 19 1 Q9UM00-1;Q9UM00-2;Q9UM00;J3QQY2;J3KS45 Q9UM00-1 TMCO1 Transmembrane and coiled-coil domain-containing protein 1 1 72250400.0 5198600.0 33388000.0 33663800.0 True False 6729690.179726075 31529928.44958918 27537333.81975707 1.0 4.685197625379029 4.091917025053588 22.682108657152114 -10.289462640963759 5.087979770070776 0.9991781073627066 4.388557325217201 0.9775260088264768 0.24220579085134236 0.0022584521836270122 0.0003153941872354155 0.2345494628138097 0.07817158285974138 5.134963477707786e-11 10.289462640963759 3.3893792178544944 VVALFYFASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVALFYFASK 10 0 Q07812-5;Q07812-7;Q07812-8;Q07812;Q07812-2;K4JQN1;H0YA56;I6LPK7;Q07812-6;Q07812-4 Q07812-5 BAX Apoptosis regulator BAX 0 1550540.0 602380.0 948160.0 0.0 False True 825096.164707408 906267.1560541715 0.0 1.0 1.098377613202878 0.0 19.654202749263547 -6.961059536720032 1.1847246059328258 1.0583359448740137 3.8723464138703454e-20 0.9752246944835918 0.07810593950198925 0.10330246175607372 0.2873036547167856 0.05501097156653767 0.10361827640416094 1.0938064078625321e-07 6.961059536720032 -1.0583359448740137 down VVANSK(ub)ESYELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVANSKESYELR 12 1 P35268;K7ERI7;K7EMH1 P35268 RPL22 60S ribosomal protein L22 1 44697400.0 25384900.0 15913000.0 3399500.0 True False 33279849.727721296 13538842.428388182 3047752.3503066176 1.0 0.4068180156808418 0.09157951058198183 24.98814558334076 -8.651894339435698 0.3554810583549543 1.1451941946050794 5.5735679994501e-25 0.9978016574737375 0.01765758734115307 0.2543927378810737 0.11213422609724226 0.13114300903770942 0.08429719211649632 2.2289773766530116e-09 8.651894339435698 -1.1451941946050794 VVANSK(ub)ESYELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVANSKESYELR 12 1 P35268;K7ERI7;K7EMH1 P35268 RPL22 60S ribosomal protein L22 1 60343400.0 27503700.0 24424600.0 8415100.0 True False 26630610.09826425 34177470.15260635 6210932.862411323 1.0 1.283390430279102 0.23322533128207015 24.66658214479378 -6.834862093684698 1.30610293594411 1.1509921176004765 0.20206617272264266 0.9152393664327886 0.1291508937418092 0.17489020005810849 0.5817528389333412 0.07759736203744307 0.17859169763289887 1.462641549421809e-07 6.834862093684698 -0.9489259448778338 down VVANSK(ub)ESYELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVANSKESYELR 12 1 P35268;K7ERI7;K7EMH1 P35268 RPL22 60S ribosomal protein L22 1 66000900.0 28463200.0 16356000.0 21181700.0 True False 43180755.33865063 13437144.00998871 16995127.710731067 1.0 0.3111836257750977 0.3935810658578015 25.36388514411189 -10.612588819225232 6.543059253564856 1.0018900111568512 0.3523823458214055 0.988004720388698 0.033638614052362396 0.0009293894608875243 5.502859874237015e-05 0.03263896036084176 0.010856816001191524 2.4401199787405402e-11 10.612588819225232 -0.6495076653354457 VVANSK(ub)ESYELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVANSKESYELR 12 1 P35268;K7ERI7;K7EMH1 P35268 RPL22 60S ribosomal protein L22 1 41215500.0 25384900.0 11732000.0 4098600.0 True False 34770383.53112832 11213641.447464097 3130595.0933166523 1.0 0.3225055437603972 0.09003625428848018 25.05135564486365 -9.864132594169751 0.28459458009228805 1.4744789082252696 1.8507173260736136e-20 0.9988429854855783 0.013130298400385619 1.2939762505210382 0.12712040284560508 0.6007156213861676 0.0870788737288351 1.3673113089243652e-10 9.864132594169751 -1.4744789082252696 VVANSK(ub)ESYELR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVANSKESYELR 12 1 P35268;K7ERI7;K7EMH1 P35268 RPL22 60S ribosomal protein L22 1 79634400.0 27503700.0 48195200.0 3935500.0 True False 22870545.170501534 47935562.891601786 4758394.854303943 1.0 2.095951912568711 0.20805777994489297 24.446987420228055 -6.749318968636459 1.652351007043347 1.6449534693933014 0.20449510695185077 0.6460527636441984 0.4605111593181477 0.30122869708532996 1.6179263357494884 0.22018118686552396 0.5349261474059179 1.7810701756437522e-07 6.749318968636459 -1.4404583624414506 VVANSK(ub)ESYELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVANSKESYELR 12 1 P35268;K7ERI7;K7EMH1 P35268 RPL22 60S ribosomal protein L22 1 75492800.0 28463200.0 33502600.0 13527000.0 True False 36846173.49355199 31638150.858847696 11065224.798740884 1.0 0.8586549934251466 0.30030865486418223 25.13501146620434 -6.945162939953451 0.6096477441384257 1.0061790890416122 0.12372552741358574 0.9987648603963138 0.01061663359504573 0.08548834028916738 0.044464023373075715 0.010795163343990657 0.04707530589100606 1.1345850586604397e-07 6.945162939953451 -0.8824535616280265 down VVAVFVQGPAWQFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVAVFVQGPAWQFK 14 0 A0A3B3IRP5;Q6P1J9;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 0 3256100.0 1243900.0 2012200.0 0.0 False True 1630764.9459447335 1711987.603494167 0.0 1.0 1.0498064774763598 0.0 20.637117420191878 -6.989013007534798 1.1388625406341493 1.0390265062025266 5.844388513586582e-19 0.9814290456802303 0.06589887316875508 0.09459548300382563 0.24100967151603406 0.04863715858345606 0.08981364993246119 1.0256212074560096e-07 6.989013007534798 -1.0390265062025266 down VVAVFVQGPAWQFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVAVFVQGPAWQFK 14 0 A0A3B3IRP5;Q6P1J9;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 0 55519000.0 16196000.0 17863000.0 21460000.0 False True 24570516.08620205 14675208.085743977 17218421.593747877 1.0 0.5972690208971664 0.7007757400511886 24.550424825012342 -10.010979557680942 7.037199712995567 1.0000000384897463 0.6490223804741807 0.9387654399038082 0.042256441146153755 2.5517388264848694e-08 3.552080107586072e-09 0.040914628084648706 0.013638207735753794 9.750355317343943e-11 10.010979557680942 -0.3509776580155656 VVAVFVQGPAWQFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVAVFVQGPAWQFK 14 0 A0A3B3IRP5;Q6P1J9;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 0 7896400.0 1243900.0 2484000.0 4168500.0 False True 1703803.4451335422 2374248.666510464 3183986.152952342 1.0 1.3934991581874476 1.8687520336025525 20.70032748171477 -6.968607802299803 0.28951237310223976 0.9065955446628481 2.3703290579308955 0.9999693959234638 0.0019649342713284786 0.07675705429325164 0.010638812245492462 0.008324732609207743 0.04312242837922237 1.0749597365012989e-07 6.968607802299803 1.4637335132680476 VVAVFVQGPAWQFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVAVFVQGPAWQFK 14 0 A0A3B3IRP5;Q6P1J9;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 0 10676300.0 5551200.0 2472800.0 2652300.0 False True 4616068.759857331 2459478.5355876307 3206883.667150387 1.0 0.5328080372146895 0.6947218150297878 22.138233283508253 -10.112927346224362 5.5911829416815415 1.000004237075664 0.61376492612217 0.8835459491612575 0.06610102299580176 3.4913135747564316e-06 5.539478993057232e-07 0.06400274252084454 0.02133401343579931 7.710324454507164e-11 10.112927346224362 -0.38623931095349406 VVAVFVQGPAWQFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVAVFVQGPAWQFK 14 0 A0A3B3IRP5;Q6P1J9;A0A1B0GUB2 A0A3B3IRP5 CDC73 Parafibromin 0 51693000.0 16196000.0 21247000.0 14250000.0 False True 20966041.27088903 20064585.772385933 11656646.217347367 1.0 0.957004019649873 0.5559774526215595 24.321551147104792 -6.927358842444876 0.7681683111968375 1.0067331310814729 0.47892703601582476 0.9959930492644422 0.012657052056698925 0.09403287892262509 0.08457203272980894 0.011354886416402045 0.03682711550262434 1.1820644533099213e-07 6.927358842444876 -0.5278060950656481 VVCDENGSK(ub)GYAFVHFETQEAADK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVCDENGSKGYAFVHFETQEAADK 24 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEQ8 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 25285600.0 4953800.0 10396000.0 9935800.0 True False 7515276.771290905 8540752.57568127 7971984.774984158 1.0 1.1364521674448216 1.0607706166508628 22.841394805763372 -10.080995093232831 4.299245172389847 0.9999891771550714 1.0986113920610385 0.6935963445664638 0.030896863777056725 21466418.2765135 0.8201178821834356 2345.6508486387297 0.010576818272529829 8.29860143427941e-11 10.080995093232831 0.09862221490596712 VVCDENGSK(ub)GYGFVHFETQEAAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVCDENGSKGYGFVHFETQEAAER 24 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 29707200.0 10991000.0 12621000.0 6095200.0 True False 14409307.4369954 10737995.996272681 5464527.173286925 1.0 0.745212498464933 0.37923593463325933 23.780497660291623 -6.965967324935109 0.3410445482503264 1.0392181546176904 0.0730486200186997 0.999931717159537 0.0021053048660952664 0.07763423607360385 0.013711052690852541 0.005149934024464788 0.03165273256026027 1.0815153183318892e-07 6.965967324935109 -0.9661695345989907 down VVCDENGSK(ub)GYGFVHFETQEAAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVCDENGSKGYGFVHFETQEAAER 24 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 143124000.0 41744000.0 69387000.0 31993000.0 True False 63328699.89518506 57004347.7268945 25669569.526969947 1.0 0.9001345017542132 0.4053386469239933 25.916356126153335 -6.94000918658132 0.6594814199103176 1.005553048827711 0.27187339803908517 0.9981650571861631 0.011137585359386973 0.08776253955458158 0.05459130414680875 0.010842326002773711 0.042584395989056376 1.1481293349919975e-07 6.94000918658132 -0.7336796507886257 down VVCDENGSK(ub)GYGFVHFETQEAAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVCDENGSKGYGFVHFETQEAAER 24 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 36474700.0 10991000.0 16049000.0 9434700.0 True False 15054669.720606782 15339902.113054145 7206418.173745821 1.0 1.0189464397254056 0.4786832462941183 23.843707721814514 -6.898769859909777 0.9689836097423647 1.0232266047092042 0.4233636467306852 0.9859451317345647 0.02967817830344361 0.11231743153533125 0.18255816445821363 0.023022796035148348 0.05954193670172707 1.2624963758298638e-07 6.898769859909777 -0.5998629579785191 down VVCDENGSK(ub)GYGFVHFETQEAAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVCDENGSKGYGFVHFETQEAAER 24 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 26762600.0 15444000.0 6635000.0 4683600.0 True False 12842370.285206195 6599255.938055619 5662919.1054803515 1.0 0.5138658823486542 0.4409559123212455 23.614408165980127 -13.999999999999998 0.2671440745782727 4.695287578341654 0.41607661773617816 0.9995772247568261 0.005102179586679347 14.745014202491149 0.16359482660570443 29.54101070766691 0.03071955833515773 1.0000000000000041e-14 13.999999999999998 -4.279210960605476 VVCDENGSK(ub)GYGFVHFETQEAAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVCDENGSKGYGFVHFETQEAAER 24 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E5RGH3 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 141293300.0 41744000.0 74504300.0 25045000.0 True False 54038430.897258 70358070.21045673 20487066.983401 1.0 1.3020006140486735 0.3791203157314575 25.687482448245785 -6.818572684782964 1.3781816215721883 1.163011748373653 0.3596044032589974 0.8810423872567924 0.13250734492240837 0.1953396923879787 0.7294504403121477 0.07556470203559591 0.1742221321453995 1.5185437728769876e-07 6.818572684782964 -0.8034073451146557 down VVCVGMNYVDHCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVCVGMNYVDHCK 13 0 Q96GK7;Q6P2I3;C9JGM0 Q96GK7 FAHD2A;FAHD2B Fumarylacetoacetate hydrolase domain-containing protein 2A;Fumarylacetoacetate hydrolase domain-containing protein 2B 0 14595400.0 4653600.0 6884900.0 3056900.0 False True 6100914.6655265 5857699.757130005 2740601.31185536 1.0 0.9601346811535012 0.4492115464819159 22.540594120933545 -6.922466534180697 0.8062229256223394 1.0103027385832872 0.36195784525135744 0.9948390590301739 0.018015703942494136 0.09674224014544905 0.09825304800256579 0.01572864286231803 0.04828541879714025 1.1954556414218188e-07 6.922466534180697 -0.6483448933319298 down VVCVGMNYVDHCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVCVGMNYVDHCK 13 0 Q96GK7;Q6P2I3;C9JGM0 Q96GK7 FAHD2A;FAHD2B Fumarylacetoacetate hydrolase domain-containing protein 2A;Fumarylacetoacetate hydrolase domain-containing protein 2B 0 13740400.0 3145000.0 6136500.0 4458900.0 False True 4771194.930297938 5041393.630306665 3577596.4605947062 1.0 1.056631243107029 0.7498323822144283 22.185919199102536 -6.859042785367779 1.190535534280452 1.0306518111603071 0.7352431146991562 0.952468137187357 0.02906148214486833 0.1477927712040602 0.398588735616972 0.01904596344508452 0.04441296030379626 1.3834300809458802e-07 6.859042785367779 -0.295408696461151 VVCVGMNYVDHCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVCVGMNYVDHCK 13 0 Q96GK7;Q6P2I3;C9JGM0 Q96GK7 FAHD2A;FAHD2B Fumarylacetoacetate hydrolase domain-containing protein 2A;Fumarylacetoacetate hydrolase domain-containing protein 2B 0 14339700.0 4653600.0 3757400.0 5928700.0 False True 6374161.678811363 3591385.643939785 4528463.1654092735 1.0 0.5634287024563671 0.7104405871069354 22.603804182456436 -10.413926054547462 5.226046225113016 1.0003141487087313 0.636934644781641 0.8904963303364912 0.0600173505865011 0.00021986517037538464 2.4656577742368526e-05 0.05816099254526405 0.019370516608745704 3.855439969948106e-11 10.413926054547462 -0.3633795039270903 VVCVGMNYVDHCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVCVGMNYVDHCK 13 0 Q96GK7;Q6P2I3;C9JGM0 Q96GK7 FAHD2A;FAHD2B Fumarylacetoacetate hydrolase domain-containing protein 2A;Fumarylacetoacetate hydrolase domain-containing protein 2B 0 14739200.0 3145000.0 6577100.0 5017100.0 False True 4071264.497218199 6211078.603264439 4104039.2797932187 1.0 1.5255895576198317 1.0080502710146722 21.957045521194985 -10.695757733647211 2.9685929548026015 0.966661652994161 1.2668199142329726 0.2616633860710347 0.21128453026126884 95486420.5195267 121526122.69995506 24585835.94531779 0.07732221879896774 2.0148478969455474e-11 10.695757733647211 0.3001582612388116 VVDALGNAIDGK(ub)GPIGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVDALGNAIDGKGPIGSK 18 1 P25705;P25705-2;K7EK77;K7ENJ4;K7ERX7;K7EJP1 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 1 27388700.0 1969000.0 3850700.0 21569000.0 True False 2987116.9531817595 3163512.4993435806 17305877.695971478 1.0 1.0590521057349065 5.793505231704415 21.510322293237436 -6.909622316044049 0.8983117770261428 0.8516554835126876 6.400418557475024 0.9907780570776776 0.21567501384948637 0.10466806285252635 0.14012919910472313 0.17624696398792006 0.4852522144047559 1.2313391387233488e-07 6.909622316044049 5.548763073962336 up VVDDDGMTSLHK(ub)AAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVDDDGMTSLHKAAER 16 1 Q53RE8 Q53RE8 ANKRD39 Ankyrin repeat domain-containing protein 39 1 8380300.0 1146100.0 1295000.0 5939200.0 True False 1109717.682843421 1812100.2533357837 4383545.3478192 1.0 1.632938071864056 3.9501446319096907 20.08176126448827 -6.9469109379917064 0.5917865540087007 0.9733552222551209 4.72668447133057 0.9989360316437143 0.04136457173609219 0.08475038987456282 0.041282428419281446 0.04280559488121843 0.19422891250249827 1.1300276289022678e-07 6.9469109379917064 3.753329249075449 VVDDDGMTSLHK(ub)AAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVDDDGMTSLHKAAER 16 1 Q53RE8 Q53RE8 ANKRD39 Ankyrin repeat domain-containing protein 39 1 87877100.0 2564100.0 15216000.0 70097000.0 True False 3889927.1608193736 12500585.916849377 56242297.22539345 1.0 3.2135784039247293 14.45844482433614 21.891311710214683 -6.939452091763509 0.6646425125993254 0.8725104794963546 17.44255510916811 0.998091231317187 0.2574329933180208 0.08801753688044202 0.05575492442730789 0.24956303341568561 0.9701834367730374 1.1496030523468314e-07 6.939452091763509 16.570044629671756 VVDDDGMTSLHK(ub)AAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVDDDGMTSLHKAAER 16 1 Q53RE8 Q53RE8 ANKRD39 Ankyrin repeat domain-containing protein 39 1 5802200.0 1146100.0 1763600.0 2892500.0 True False 953032.9308388236 1754099.1367528096 3497308.376591065 1.0 1.840544098732158 3.669661628074978 19.862166539922548 -6.95836121897004 0.45794463838990446 0.9455760502533065 4.638111417421268 0.9997045095031242 0.01915831779494965 0.0802917934617155 0.023334124549132803 0.024755895174625155 0.15113867922180652 1.1006234989925264e-07 6.95836121897004 3.6925353671679613 VVDDDGMTSLHK(ub)AAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVDDDGMTSLHKAAER 16 1 Q53RE8 Q53RE8 ANKRD39 Ankyrin repeat domain-containing protein 39 1 107288000.0 2564100.0 7511900.0 97212000.0 True False 3319277.9959673043 7093856.1615092 79520413.4793523 1.0 2.1371684354632996 23.957141756720635 21.662438032307133 -6.9176979004965675 0.8416358592206331 0.47746176793508527 27.295877996381844 0.9935169425730261 0.8506081573378368 0.09954515933454111 0.11277680772595138 0.7240887257398088 2.1234356693805054 1.2086542945450315e-07 6.9176979004965675 26.818416228446758 up VVDFDETWNK(ub)LLTTIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVDFDETWNKLLTTIK 16 1 Q5T2B5;A0A0A0MTN0;Q13617;Q13617-2;Q5T2B7 Q5T2B5 CUL2 Cullin-2 1 20983300.0 3779600.0 7367100.0 9836600.0 True False 5733929.525772367 6052383.445584972 7892391.698465067 1.0 1.0555385130530899 1.376436815798142 22.451092742224283 -6.93663799109578 0.690129269381014 0.9961041998393143 1.455036360939451 0.9976896000877704 0.007975209910354256 0.08933431574987971 0.06184784176177254 0.007578152295640974 0.028052472319569578 1.1570763285968003e-07 6.93663799109578 0.4589321611001367 VVDGPTPHQTVRLEALDESGSYWVSDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVDGPTPHQTVRLEALDESGSYWVSDK 27 1 A0A2R8YDS4;P35228-2;P35228 A0A2R8YDS4 NOS2 Nitric oxide synthase, inducible 0 3904100.0 1654500.0 1129600.0 1120000.0 False True 2169065.5222007907 961068.0831463126 1004113.1437986207 1.0 0.4430793230124223 0.46292430243408283 21.048642203305498 -10.487352658741212 9.603047535638199 1.0000065314424116 0.45300181274218015 0.9990138056605571 0.008101678923183451 1.1329179782564201e-06 6.048546963524216e-08 0.007844510352563928 0.00261480562881743 3.255722202785106e-11 10.487352658741212 -0.5470047187002314 VVDGPTPHQTVRLEALDESGSYWVSDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVDGPTPHQTVRLEALDESGSYWVSDK 27 1 A0A2R8YDS4;P35228-2;P35228 A0A2R8YDS4 NOS2 Nitric oxide synthase, inducible 0 8267500.0 2494300.0 3568500.0 2204700.0 False True 2074120.9662257044 3549275.7822082057 2665692.576618956 1.0 1.711219277951205 1.28521557808161 20.984068606332 -10.334218552431347 4.8729114585453015 0.9997161264973148 1.4982174280166562 0.6458528477657183 0.17391528220390212 123867442.94111088 171.70852253706695 394535.79268157965 0.059535826973585435 4.63213755434464e-11 10.334218552431347 0.49850130151934147 VVDK(ub)SEYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVDKSEYR 8 1 G3V1A9;P42695;E9PKK4 G3V1A9 NCAPD3 Condensin-2 complex subunit D3 1 4667430.0 639030.0 789600.0 3238800.0 True False 969455.2293508082 648689.7108270419 2598649.760383528 1.0 0.6691280743943527 2.680525806357972 19.886814748854515 -6.864669554200845 1.161848868357683 0.8177103303180894 2.7870150553399373 0.9590715350826952 0.1781555676325282 0.14207232410235682 0.3617997195826718 0.1193438247119792 0.2802310541956095 1.3656218151252553e-07 6.864669554200845 1.969304725021848 up VVDK(ub)SEYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVDKSEYR 8 1 G3V1A9;P42695;E9PKK4 G3V1A9 NCAPD3 Condensin-2 complex subunit D3 1 2456870.0 662590.0 548280.0 1246000.0 True False 907567.4288214769 524055.17668049823 951720.4621755097 1.0 0.5774283651419828 1.0486498655106737 19.791645308302808 -6.670333109902732 1.9362436802607248 0.7303525947922375 1.0467464379745481 0.28053017499175803 0.1794851659313043 0.4603346332886749 3.327542221992409 0.07461928174447748 0.19927371036992622 2.1363228716015146e-07 6.670333109902732 0.3163938431823107 VVDK(ub)SEYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVDKSEYR 8 1 G3V1A9;P42695;E9PKK4 G3V1A9 NCAPD3 Condensin-2 complex subunit D3 1 3558830.0 639030.0 446600.0 2473200.0 True False 827236.9321644979 421746.3174070486 2023102.9771749836 1.0 0.5098253003568552 2.445614912140655 19.657941070946965 -6.839596661648397 1.284375847833136 0.7392341937796743 2.508733910944026 0.9237414746261363 0.2269239080057912 0.1692707492675741 0.5426041051143062 0.13855408113321313 0.3191486775619922 1.4467828043909392e-07 6.839596661648397 1.7694997171643516 up VVDLLAPYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVDLLAPYAK 10 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 40826200.0 5060200.0 19634000.0 16132000.0 False True 6633971.203046507 16704683.732732564 14462815.389070857 1.0 2.5180518910093097 2.18011428545682 22.661441318967118 -10.45061780103192 5.670082779607401 0.9989648681830069 2.349083088233053 0.9550546134531841 0.13796244975026223 0.0018063473910600147 0.000175019464170505 0.13365942761666577 0.0445271891903942 3.543090120245259e-11 10.45061780103192 1.3501182200500463 VVDLLAPYAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVDLLAPYAK 10 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 36807900.0 16035000.0 5599900.0 15173000.0 False True 15525977.702115221 7835969.273092714 11198736.11975699 1.0 0.504700536316316 0.7212902359270619 23.888180784933 -10.296863986267335 5.713771876004098 1.0000371669875725 0.612995386121686 0.8097745212615082 0.08842237459818052 4.186838906260999e-05 5.152224278795584e-06 0.08562279806078948 0.028538198687570508 5.048193737523338e-11 10.296863986267335 -0.3870417808658865 VVDLLAPYAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVDLLAPYAK 10 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 118475300.0 3999300.0 111190000.0 3286000.0 False True 6067230.487993808 91347275.76856479 2636520.659695038 1.0 15.055844004826938 0.43455093141958917 22.53260668827197 -6.6494772111108755 2.0100227604829106 9.999999998464334 0.49561751194003023 0.2202006847288689 5.972334050255879 0.49671240475566714 3.8459025918588168 2.4182312345537245 6.639087168236066 2.241417657404106e-07 6.6494772111108755 -9.504382486524303 VVDLLAPYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVDLLAPYAK 10 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 41074200.0 5060200.0 17031000.0 18983000.0 False True 6931092.686763214 16278514.106014406 14499606.36715707 1.0 2.3486216159109525 2.0919654407230723 22.72465138049001 -10.175926864076695 5.216343561521683 0.9999386530934677 2.220293528317637 0.9678884412190224 0.10477944475966929 7.476211412002879e-05 1.1811000740854432e-05 0.10145730561506945 0.03381742038126811 6.669190700538635e-11 10.175926864076695 1.2203548752241693 VVDLLAPYAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVDLLAPYAK 10 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 20906500.0 16035000.0 2107000.0 2764500.0 False True 13333812.970945412 2095649.172793244 3342544.168396197 1.0 0.15716803418194752 0.2506817948984025 23.668586060367275 -10.498655731367625 6.191474644857074 1.0006264605154156 0.20392491623844053 0.9897568677833676 0.038176832947339624 0.0003303667209041718 2.6750781222234e-05 0.03699068001392568 0.012321519851332407 3.172081000078898e-11 10.498655731367625 -0.796701544276975 VVDLLAPYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVDLLAPYAK 10 0 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 0 14217000.0 3999300.0 5303300.0 4914400.0 False True 5177172.687988785 5008166.693024637 4020029.626002233 1.0 0.9673555422718954 0.7764913145216958 22.303733010364418 -6.93638469926491 0.6923775694335114 1.0023341542324538 0.730069933422372 0.9976510162546594 0.004777499958022199 0.08945533423520544 0.06241414603227419 0.004531814455174734 0.01670563684324609 1.1577513624181088e-07 6.93638469926491 -0.2722642208100817 VVDLLAPYAKGGK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVDLLAPYAKGGK 13 1 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 1 10174300.0 2788200.0 2968200.0 4417900.0 True False 3655357.2009672103 2525356.1299529825 3960778.0874892212 1.0 0.6908643919354233 1.0835543203387061 21.80158096233748 -6.696780636499998 1.8421090099750739 0.8074389073878506 1.0823272787224907 0.4024083348948857 0.13056823388896704 0.40226560101350173 2.6514527897215623 0.05659230414503749 0.14613471389061067 2.0101078679991395e-07 6.696780636499998 0.27488837133464006 VVDLLAPYAKGGK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVDLLAPYAKGGK 13 1 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 1 22073500.0 8515500.0 6083400.0 7474600.0 True False 8245180.113649045 8512533.344511915 5516778.026806535 1.0 1.0324253960711294 0.6690912691736204 22.975119578600026 -6.885124602789929 1.0507577708798241 1.0218643329930157 0.6406664224531471 0.977591249380337 0.024575391419704648 0.12318956769267614 0.2456512002654438 0.017924495261012266 0.043971012977186606 1.3027929424228682e-07 6.885124602789929 -0.3811979105398686 VVDLLAPYAKGGK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVDLLAPYAKGGK 13 1 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 1 56407000.0 10895000.0 11557000.0 33955000.0 True False 16528511.531191124 9494563.054746859 27243779.366994794 1.0 0.5744354557777069 1.6482899452611193 23.978453473339155 -6.799161120974406 1.45914895662021 0.7649475650090531 1.6628403558613203 0.8297566011756938 0.1821782703301999 0.22195306216365743 0.9330133420222294 0.09822121309189807 0.22856301031259743 1.5879575153957967e-07 6.799161120974406 0.8978927908522671 VVDLLAPYAKGGK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVDLLAPYAKGGK 13 1 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 1 12181900.0 2788200.0 3476200.0 5917500.0 True False 3819072.8882718463 3322609.9897438325 4519908.374738031 1.0 0.8700043405684602 1.1835093246369845 21.86479102386037 -6.794116860186692 1.4800763036982505 0.9277322660552848 1.1872211404802488 0.8143181601426824 0.05541819130487724 0.22927002914545808 0.9920892585787516 0.029466758966319246 0.06878087284018722 1.6065089145882663e-07 6.794116860186692 0.25948887442496404 VVDLLAPYAKGGK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVDLLAPYAKGGK 13 1 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 1 20208200.0 8515500.0 4820400.0 6872300.0 True False 7081015.550613401 4794431.548425511 8309266.156074953 1.0 0.6770824769633769 1.173456843398 22.755524854034302 -6.731128409039652 1.7191125247384986 0.8059152879111704 1.1732233766006706 0.5645023429624041 0.1357350183947618 0.33412123143334865 1.9350044115003913 0.06255681922849374 0.1550327763536441 1.857255234155964e-07 6.731128409039652 0.36730808868950016 VVDLLAPYAKGGK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVDLLAPYAKGGK 13 1 P06576;H0YH81;F8W079 P06576 ATP5B ATP synthase subunit beta, mitochondrial;ATP synthase subunit beta 1 63833000.0 10895000.0 11528000.0 41410000.0 True False 14103792.272557177 10886456.666073576 33873804.90248099 1.0 0.771881523471966 2.401751546524961 23.749579795431604 -6.871480965481664 1.1262875137616117 0.8697647232152073 2.4999070399910885 0.9661362363092475 0.13260620430741898 0.13543992167423005 0.32021396633282007 0.09129202344122161 0.2167018874158193 1.3443706872627388e-07 6.871480965481664 1.6301423167758813 up VVDLMAHMASK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VVDLMAHMASK 11 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 491301000.0 118577000.0 123517000.0 249207000.0 False True 155455595.30130127 105088745.06549495 223421450.20234188 1.0 0.6760049058498911 1.4372043011337765 27.21192730352419 -6.791048910026149 1.492078571431287 0.8191662024314079 1.445542463838694 0.8047236628751985 0.13782968914664312 0.23379113766534304 1.0282082711917853 0.07270406972652532 0.17009336623100288 1.617897820543738e-07 6.791048910026149 0.6263762614072861 VVDLMAHMASK ddPTM_RPMI8226_Bortezomib_2h_R1 3 VVDLMAHMASK 11 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 430484700.0 76892400.0 43886000.0 309706300.0 False True 74451492.8507718 61409908.662466615 228584929.0401568 1.0 0.8248311257580111 3.0702531311000727 26.149797441250108 -6.8880474033631 1.0338297379838248 0.873643535806726 3.256174971698727 0.9796200820979513 0.14557415982194838 0.12074312181410038 0.23119898072638867 0.10755242781532524 0.2663212558727405 1.2940545873242042e-07 6.8880474033631 2.382531435892001 up VVDLMAHMASK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VVDLMAHMASK 11 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 1237466000.0 120282000.0 842951000.0 274233000.0 False True 182476587.79208165 692519808.043776 220030727.3494062 1.0 3.7951159456842225 1.2058025087586286 27.443136133540957 -6.628027832603242 2.0874532763521754 2.8440628418065494 1.216093495607503 0.11053877117143762 1.1995450392523908 0.564116026090611 4.681642059861313 0.47040110043326594 1.3291243834368613 2.354898360836308e-07 6.628027832603242 -1.6279693461990465 VVDLMAHMASK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VVDLMAHMASK 11 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 548502200.0 118577000.0 79356200.0 350569000.0 False True 162418121.32293597 75849980.68813923 267771822.39518964 1.0 0.46700442087571437 1.6486573063037646 27.275137365047083 -6.7840537087894175 1.5198821922524184 0.6998027920917045 1.659271922257306 0.7815672213292508 0.22582164803107088 0.24430694403124287 1.1148853629825775 0.11699065478051165 0.27515113862819546 1.6441683778871462e-07 6.7840537087894175 0.9594691301656015 VVDLMAHMASK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VVDLMAHMASK 11 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 244300400.0 75027000.0 60359200.0 108914200.0 False True 62388274.759658456 60034033.00923688 131687655.65763706 1.0 0.9622646761832901 2.1107757213185354 25.89477157894675 -6.899301385196676 0.9656580792912988 0.9513294700108004 2.2296420226925604 0.9862159854681336 0.06254673157684952 0.11192189370360131 0.1803273801089587 0.04864114148312524 0.1261203273130095 1.2609521741384273e-07 6.899301385196676 1.27831255268176 up VVDLMAHMASK ddPTM_RPMI8226_Carfilzomib_8h_R1 3 VVDLMAHMASK 11 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 571030200.0 125687200.0 415076600.0 30266400.0 False True 162704558.06510738 391977222.3283445 24758225.759489287 1.0 2.4091348576202276 0.15216676197591286 27.27767942686297 -6.737880109154927 1.694472455512173 1.8404741939515619 0.15144351469109826 0.5954065648185796 0.5920938625452355 0.3216519680823909 1.8125425923185514 0.27652667092393 0.680153223343484 1.8286049490923026e-07 6.737880109154927 -1.6890306792604637 VVDLMAHMASKE ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVDLMAHMASKE 12 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 33334000.0 13234000.0 20100000.0 0.0 False True 17349902.15823831 17101158.349186346 0.0 1.0 0.9856631001844669 0.0 24.048424191209747 -7.03475142031721 1.0715412131430155 1.017616655798011 1.8998926094780286e-18 0.9868554496638983 0.053663146687214294 0.08653323758399618 0.19224404039450974 0.04212540045317843 0.07591805673791767 9.23099635932434e-08 7.03475142031721 -1.017616655798011 down VVDLMAHMASKE ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVDLMAHMASKE 12 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 41316000.0 13234000.0 28082000.0 0.0 False True 18126967.435402628 26841244.385244317 0.0 1.0 1.4807355108291522 0.0 24.11163425273264 -6.841228636908207 1.426392448115614 1.25773331452445 8.220399817200032e-21 0.8819842608435541 0.2118827325557149 0.1831543148624508 0.748272251817787 0.11916566707397205 0.25454277902715366 1.4413563411471644e-07 6.841228636908207 -1.25773331452445 down VVDSLYNK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVDSLYNKAK 10 1 O00231;O00231-2 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 1 1492330.0 251180.0 858150.0 383000.0 True False 329299.4124305801 730117.3650425003 343370.8339954218 1.0 2.217183928915807 1.0427313898344963 18.329040412169512 -6.637851304309406 2.0522657519427394 1.7972751973221421 1.0476018505844642 0.1463570852489201 0.5210805881478788 0.5388464756071208 4.3348557749796965 0.20695972109758431 0.5769974087790367 2.3022299302807987e-07 6.637851304309406 -0.7496733467376779 VVDSLYNK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVDSLYNKAK 10 1 O00231;O00231-2 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 1 7760400.0 1119300.0 2259300.0 4381800.0 True False 1698059.9317909307 1856110.2630085298 3515735.309388836 1.0 1.093077004090724 2.0704424170004514 20.695455947986456 -6.925409380215942 0.7835427429070949 0.9823419216562765 2.249497300736256 0.9955569609673507 0.0322726520211695 0.09509168894033594 0.08987314368760692 0.028635613414141597 0.09076829123515034 1.187382434135103e-07 6.925409380215942 1.2671553790799797 up VVDSLYNK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVDSLYNKAK 10 1 O00231;O00231-2 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 1 5678700.0 1119300.0 1335400.0 3224000.0 True False 1448955.9147015344 1261083.816089056 2637265.081033532 1.0 0.870339672376314 1.8201140933792823 20.466582270078906 -6.872420037531791 1.1211682229234352 0.9254719813158019 1.8783683107031819 0.9670416345210606 0.07634152944409932 0.13455798134826594 0.3146459904113194 0.05276104901913529 0.12547059768765212 1.3414669040746144e-07 6.872420037531791 0.95289632938738 VVENLQDDFDFNYK(ub)TLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVENLQDDFDFNYKTLK 17 1 G8JLH9;P40763-3;P40763-2;P40763 G8JLH9 STAT3 Signal transducer and activator of transcription;Signal transducer and activator of transcription 3 1 34068900.0 7885600.0 7221300.0 18962000.0 True False 10208064.64841457 6819428.306967131 15511110.566550227 1.0 0.6680432130713696 1.5194957223315861 23.28320603514833 -6.800977214101904 1.4519815102766367 0.8170717613622455 1.5315266864391306 0.8349896332346081 0.14233897967816955 0.21936504963891637 0.9129483345531645 0.07711791896152016 0.1792371648034208 1.5813310039484832e-07 6.800977214101904 0.7144549250768851 VVESPDFSK(ub)DEDYLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVESPDFSKDEDYLGK 16 1 Q9Y6Y8 Q9Y6Y8 SEC23IP SEC23-interacting protein 1 8697700.0 3594100.0 2974700.0 2128900.0 True False 3480007.262810871 4162513.2228555726 1571277.2243689906 1.0 1.1961219930022295 0.45151550146474084 21.730658886320676 -6.836700072007461 1.297707852422596 1.104415452339208 0.428592921796651 0.9186166236059148 0.08989834279188351 0.17268952825000736 0.5663471640321674 0.05434937218719482 0.1251163195702051 1.4564645819413066e-07 6.836700072007461 -0.675822530542557 down VVESPDFSK(ub)DEDYLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVESPDFSKDEDYLGK 16 1 Q9Y6Y8 Q9Y6Y8 SEC23IP SEC23-interacting protein 1 8973600.0 2965300.0 2965900.0 3042400.0 True False 4061651.544219389 2834856.7310802736 2323847.7801948413 1.0 0.697956656354455 0.5721435615278668 21.953635043081718 -13.999999999999998 0.12011001758721651 2.439467840453471 0.37163564893402934 0.9996924015878695 0.003148901532798554 11.963345563045568 0.10667419475455889 4.110005583940224 0.1779295267333658 1.0000000000000041e-14 13.999999999999998 -2.0678321915194413 VVESPDFSK(ub)DEDYLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVESPDFSKDEDYLGK 16 1 Q9Y6Y8 Q9Y6Y8 SEC23IP SEC23-interacting protein 1 13496500.0 5694600.0 0.0 7801900.0 True False 7371771.957347775 0.0 6382034.254254197 1.0 0.0 0.8657395116370817 22.813580011821273 -9.048544562716726 11.513882269975712 0.9999944997817017 0.4328697558184875 0.3639390241669802 0.35343667562731984 0.0 0.0 0.34221358965434634 0.11407119655144875 8.942427694685201e-10 9.048544562716726 -0.5671247439632142 VVETDPSPYCIVAPDTVIHCEGEPIK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVETDPSPYCIVAPDTVIHCEGEPIKR 27 1 P55072;C9IZA5 P55072 VCP Transitional endoplasmic reticulum ATPase 1 40346000.0 14585000.0 14607000.0 11154000.0 True False 19121076.241340898 12427692.537640033 9999891.076723056 1.0 0.6499473345946201 0.522977417719966 24.188660392778498 -13.999999999999998 0.1410873298554397 2.673817794366665 0.36788498875053033 0.9995986340220582 0.004041224266742934 11.935246082615308 0.11776203955301681 5.49669641611994 0.13875419834770078 1.0000000000000041e-14 13.999999999999998 -2.3059328056161346 VVETDPSPYCIVAPDTVIHCEGEPIK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVETDPSPYCIVAPDTVIHCEGEPIKR 27 1 P55072;C9IZA5 P55072 VCP Transitional endoplasmic reticulum ATPase 1 205285000.0 59584000.0 89678000.0 56023000.0 True False 90393284.17388631 73674260.24258801 44950029.49424679 1.0 0.8150413044055738 0.49727178191443994 26.429712254894678 -6.962903999469269 0.3923669923953271 1.01900886008414 0.2818430389107812 0.9998632053254609 0.0024282018957835654 0.07867961105617971 0.017414226121329934 0.004097814725220467 0.02670373673771379 1.0891708272734506e-07 6.962903999469269 -0.7371658211733588 down VVETDPSPYCIVAPDTVIHCEGEPIK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVETDPSPYCIVAPDTVIHCEGEPIKR 27 1 P55072;C9IZA5 P55072 VCP Transitional endoplasmic reticulum ATPase 1 40780000.0 14585000.0 13886000.0 12309000.0 True False 19977468.644804824 13272470.605138613 9401867.711812478 1.0 0.6643719903217139 0.4706235749371305 24.25187045430139 -10.12409867462436 0.10877364977513451 1.80263648159565 3.8211470148407083e-13 0.9999020037103771 0.0021648622191779974 1.776571701961592 0.05259393440563818 0.6493739427055186 0.2598555329046389 7.514521396454541e-11 10.12409867462436 -1.8026364815952678 VVETDPSPYCIVAPDTVIHCEGEPIK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVETDPSPYCIVAPDTVIHCEGEPIKR 27 1 P55072;C9IZA5 P55072 VCP Transitional endoplasmic reticulum ATPase 1 161208000.0 59584000.0 71141000.0 30483000.0 True False 77132662.57623188 67181940.81203502 24935406.781992976 1.0 0.8709921136929204 0.3232794765427522 26.200838576987127 -6.943507991215791 0.6260785125798282 1.0059773889729609 0.15897329793370982 0.9985882132243769 0.011022933178824973 0.0862021084066387 0.04759125798997578 0.011040171135529268 0.04646158387851854 1.1389168250958469e-07 6.943507991215791 -0.847004091039251 down VVEVLAGHGHLYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVEVLAGHGHLYSR 14 0 P49327 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 44798500.0 13274300.0 16716200.0 14808000.0 False True 17402735.848504066 14222208.11923724 13275810.20836607 1.0 0.81723978591905 0.7628576520344791 24.052810791251268 -13.999999999996861 0.16988448252653218 1.9213864691094387 0.7148273486076967 0.9995138960096283 0.002236331297406969 12.090359489953306 0.13051859552574308 3.671043909333171 0.04438359839793749 1.0000000000072274e-14 13.999999999996861 -1.2065591205017419 VVEVLAGHGHLYSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVEVLAGHGHLYSR 14 0 P49327 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 18429640.0 7631700.0 2358940.0 8439000.0 False True 7389435.860881372 3300877.0437095906 6228572.735426696 1.0 0.4467021712961833 0.8429023341822179 22.81703279678417 -10.241594322566893 5.762740746062933 1.0000151347378645 0.6448022527392062 0.5172911815437408 0.16174803917974526 3.145303240318339e-05 4.1390778012121785e-06 0.15661853365758277 0.05220395516873564 5.733313336351361e-11 10.241594322566893 -0.3552128819986583 VVEVLAGHGHLYSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVEVLAGHGHLYSR 14 0 P49327 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 37506000.0 9079600.0 20362000.0 8064400.0 False True 13774417.00767351 16728242.010967873 6470467.805247912 1.0 1.2144428328000259 0.46974531130016733 23.71548792326662 -6.829691729317192 1.3291976622288924 1.114612065154454 0.44981991271808314 0.9052683487634419 0.09633722824625586 0.18119588499187775 0.626187918390959 0.05690692740944506 0.13096656583637978 1.4801586608213423e-07 6.829691729317192 -0.6647921524363709 down VVEVLAGHGHLYSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVEVLAGHGHLYSR 14 0 P49327 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 36423700.0 13274300.0 12580400.0 10569000.0 False True 18182167.43446918 12024556.330180462 8072819.8753876155 1.0 0.6613378945892165 0.4439965644625744 24.11602085277416 -8.58468324729199 0.13823374612451444 1.4632553652760112 1.765595650540336e-15 0.9999204651340748 0.002040319076243907 0.1930922960781407 0.03576586839142035 0.18906194307639843 0.15685518583221508 2.6020566814556903e-09 8.58468324729199 -1.4632553652760094 VVEVLAGHGHLYSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVEVLAGHGHLYSR 14 0 P49327 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 16426900.0 7631700.0 4274300.0 4520900.0 False True 6346096.69163481 4251273.497517883 5466199.2877201615 1.0 0.6699036752972508 0.8613482512684535 22.597438072218445 -10.20896734208697 5.36054461929517 1.0000134754455503 0.7656259646015093 0.6664832564331205 0.07815692085896057 1.2587747063958096e-05 1.857486713880925e-06 0.07567946174779597 0.02522503773978052 6.180628752505083e-11 10.20896734208697 -0.23438751084404097 VVEVLAGHGHLYSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVEVLAGHGHLYSR 14 0 P49327 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 26434800.0 9079600.0 9983300.0 7371900.0 False True 11753721.185673254 9427720.578973996 6030289.8420816185 1.0 0.8021051741864996 0.5130536743913926 23.486614245359068 -6.965695426196146 0.3459088893583324 1.0292815669128454 0.2761845548149603 0.9999267710014154 0.0017110646462052189 0.0777257496315447 0.014032234736700781 0.004010900932426319 0.024913681661169598 1.0821926346105748e-07 6.965695426196146 -0.7530970120978852 VVFAELACR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVFAELACR 9 0 Q8NE71-2;Q8NE71;H0YGW7;A0A0G2JIC2 Q8NE71-2 ABCF1 ATP-binding cassette sub-family F member 1 0 8500800.0 2139900.0 2601100.0 3759800.0 False True 2805429.622821075 2213026.0190083897 3370771.962548262 1.0 0.7888367617588005 1.2015172061805963 21.41979029105017 -6.767596740099603 1.5834605809821716 0.8785112590690043 1.2036408092046718 0.7213477918064444 0.0889424422818477 0.2703366117981443 1.337311521336612 0.044282326190473925 0.10565267507034709 1.7076672908546703e-07 6.767596740099603 0.32512955013566747 VVFELFSDVCPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVFELFSDVCPK 12 0 C9JN15;Q13427-2;Q13427;E9PG73;C9JT64;C9J679 C9JN15 PPIG Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase G 0 2319900.0 1180400.0 1139500.0 0.0 False True 1547515.8310098606 969491.0417362119 0.0 1.0 0.6264821479102751 0.0 20.561522737537604 -7.587985759458458 0.6822463921663725 0.9960182116007522 7.204536340183733e-21 0.98710417011592 0.046852431023934014 0.12109045422479216 0.1460477432836601 0.042252124565991436 0.07697288920681096 2.582344864485975e-08 7.587985759458458 -0.9960182116007522 down VVFELFSDVCPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVFELFSDVCPK 12 0 C9JN15;Q13427-2;Q13427;E9PG73;C9JT64;C9J679 C9JN15 PPIG Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase G 0 4185700.0 1180400.0 1208700.0 1796600.0 False True 1616825.779110568 1155295.6373636066 1372280.082138462 1.0 0.7145455325428731 0.8487495065135384 20.624732799060496 -10.15043483064991 5.233985994795261 1.0000078081099388 0.781647519528064 0.7792294583434742 0.05478854294747605 4.99209672364775e-06 8.103333563421662e-07 0.05305067455571496 0.017682926199807374 7.07237319318428e-11 10.15043483064991 -0.21836028858187484 VVFEQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVFEQTK 7 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 0 16562800.0 4622000.0 2329400.0 9611400.0 False True 4475277.139954885 3259541.567660525 7093886.004180603 1.0 0.7283440702609503 1.585127754624849 22.09354559607162 -6.82143974027978 1.3656574953410148 0.8537898760169984 1.604412837830219 0.8876605376290718 0.11982321901224573 0.1916150873019704 0.7018129636953504 0.06894218423912142 0.15884098655523704 1.508551912324366e-07 6.82143974027978 0.7506229618132205 VVFSGHYHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVFSGHYHR 9 0 Q9BRF8;Q9BRF8-2 Q9BRF8 CPPED1 Serine/threonine-protein phosphatase CPPED1 0 9295600.0 2537000.0 2652000.0 4106600.0 False True 3326031.5683429507 2256331.9374150313 3681688.425288764 1.0 0.6783856049024662 1.1069312932357416 21.6653704310569 -6.705841449584278 1.8097363082915991 0.8014507113880946 1.10581995150612 0.44550599826686355 0.13561727041223082 0.3834758666132886 2.4454844069237516 0.059690603502817755 0.15242843293139857 1.9686048485713205e-07 6.705841449584278 0.30436924011802535 VVFSGHYHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVFSGHYHR 9 0 Q9BRF8;Q9BRF8-2 Q9BRF8 CPPED1 Serine/threonine-protein phosphatase CPPED1 0 7596700.0 2253700.0 1174700.0 4168300.0 False True 2182157.5271130074 1643763.8359795718 3076497.1836804245 1.0 0.7532745989031644 1.409841931874931 21.057323821023097 -6.804903419756388 1.4357006078562382 0.8647031891281765 1.4200521422797496 0.8461323993551285 0.10621832780717419 0.21383779109825374 0.8695875367810593 0.0581877504182358 0.1349464535155806 1.5670995295817615e-07 6.804903419756388 0.5553489531515732 VVFSGHYHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVFSGHYHR 9 0 Q9BRF8;Q9BRF8-2 Q9BRF8 CPPED1 Serine/threonine-protein phosphatase CPPED1 0 6866400.0 2537000.0 1783200.0 2546200.0 False True 3474997.4598470978 1704412.32774616 1944840.0006350593 1.0 0.49047872622650934 0.5596665963377808 21.72858049257979 -10.524869803635351 6.260922703701737 1.0005033542459754 0.5250726612823049 0.9843321809155751 0.02824582969376243 0.00019865765325408505 1.5075750350668793e-05 0.027376444665557928 0.009116302333646069 2.98627773559069e-11 10.524869803635351 -0.47543069296367046 VVFSGHYHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVFSGHYHR 9 0 Q9BRF8;Q9BRF8-2 Q9BRF8 CPPED1 Serine/threonine-protein phosphatase CPPED1 0 6534800.0 2253700.0 2617100.0 1664000.0 False True 1874051.405838458 2603001.162846322 2011934.706533289 1.0 1.3889699902237895 1.0735749831969745 20.837729096457373 -10.120906006547319 5.755286953498348 0.9999979830934431 1.2312724867103986 0.4175652374324492 0.128759472439594 3.3321268604708756e-06 5.090462281326844e-07 0.12467190980300702 0.04155694103540817 7.569967125191897e-11 10.120906006547319 0.23127450361695545 VVFSGHYHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVFSGHYHR 9 0 Q9BRF8;Q9BRF8-2 Q9BRF8 CPPED1 Serine/threonine-protein phosphatase CPPED1 0 7903400.0 1660700.0 3319900.0 2922800.0 False True 2149808.8872910207 3135144.646573359 2390880.3904605536 1.0 1.458336443349605 1.1121362482938228 21.035776982807548 -10.685311872541057 6.34646567834525 0.9971289056635045 1.2852363458217133 0.47509161059029037 0.14133563778977903 0.005789208683769646 0.00028705638616240587 0.13798237834712745 0.045615880948784805 2.0638975117553634e-11 10.685311872541057 0.28810744015820877 VVFVFGPDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVFVFGPDK 9 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 39732000.0 11721000.0 12473000.0 15538000.0 False True 15366344.50632546 10612077.019373192 13930276.811020501 1.0 0.690605173859326 0.9065446115233321 23.87327066789779 -10.081483767615573 5.407354212262423 1.0000021745579408 0.798574893829245 0.5370622382697747 0.0881569062705152 2.311133733760563e-06 3.9235817007725145e-07 0.08535847955052339 0.028452519153173386 8.289268980358863e-11 10.081483767615573 -0.20142728072869587 VVFVFGPDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVFVFGPDK 9 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 24607800.0 8905100.0 5010700.0 10692000.0 False True 8622412.474905305 7011498.640455304 7891444.446875481 1.0 0.8131713323691705 0.9152246508552873 23.03966014845699 -10.119941161718911 4.50665341271893 1.0000144051956625 0.8641979916082625 0.7024699187909472 0.0416630928239173 58116743.88902189 0.33131588506855275 8854.346875359275 0.014262384844575099 7.58680354194137e-11 10.119941161718911 -0.13581641358740004 VVFVFGPDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVFVFGPDK 9 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 14828600.0 3705400.0 7667600.0 3455600.0 False True 5621362.701025744 6299256.872767763 2772599.1453567185 1.0 1.1205924982599544 0.4932254495606191 22.422488472671397 -6.856893392307204 1.201259309210365 1.0649670330732355 0.46458955371901733 0.9497537148763908 0.06092927418243438 0.1500435209402638 0.4131920303820333 0.0396052776176292 0.09215525369903739 1.3902938693313696e-07 6.856893392307204 -0.6003774793542181 down VVFVFGPDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVFVFGPDK 9 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 36658600.0 11721000.0 9572600.0 15365000.0 False True 16054570.448115015 9149650.879644973 11736103.452108113 1.0 0.5699094167118774 0.7310132332743952 23.93648072942068 -10.028347052872357 4.932120851132434 1.0000056387842113 0.6504613249890496 0.862571294721544 0.06577035771298917 4.078097137962093e-06 8.034830824998255e-07 0.06368290150493988 0.021227291672690957 9.368130828072744e-11 10.028347052872357 -0.3495443137951617 VVFVFGPDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVFVFGPDK 9 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 20803300.0 8905100.0 5516900.0 6381300.0 False True 7404985.212819848 5487179.364681095 7715600.326202441 1.0 0.7410115222352422 1.041946756739614 22.820065423891265 -6.6789876343520955 1.9058183534869098 0.8359850431080135 1.0407840240017032 0.31940537932202795 0.1097899271967971 0.4407425116106549 3.0942783935314284 0.046243700572741554 0.12210813634081731 2.0941720822726835e-07 6.6789876343520955 0.20479898089368975 VVFVFGPDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVFVFGPDK 9 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 12876300.0 3705400.0 6110900.0 3060000.0 False True 4796713.344353673 5770823.043087176 2503111.3982514334 1.0 1.2030785725146889 0.5218388547645663 22.193614794763846 -6.826814287843079 1.3420112133485267 1.1087771802833335 0.5046635123831487 0.8993552652155719 0.09059670556691989 0.1847837577569434 0.6519582910875645 0.053019940149672096 0.12204636816198933 1.4899980915715497e-07 6.826814287843079 -0.6041136679001848 VVFVFGPDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVFVFGPDKK 10 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 147378000.0 40132000.0 52219000.0 55027000.0 False True 52613440.63884086 44428128.74806775 49333333.896256 1.0 0.844425458753776 0.9376564865791464 25.64892806194223 -10.218522772735307 4.848023477815034 1.000017727307783 0.8910409726695269 0.6455338318438736 0.038061407728677575 7.294004173705318e-06 1.1757583318494006e-06 0.0368587940737639 0.012284266522086985 6.046126469475343e-11 10.218522772735307 -0.10897675463825618 VVFVFGPDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVFVFGPDKK 10 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 98075000.0 31316000.0 12643000.0 54116000.0 False True 30321890.721511774 17691415.832374 39941396.154799245 1.0 0.583453584568949 1.3172462272104604 24.85385637977539 -6.752745129518339 1.6399577710853288 0.7558704935888411 1.3189896554348306 0.6605669384163971 0.17506377521724809 0.29529266403472615 1.5633952864300746 0.08430268588367475 0.20405586510295773 1.7670745435340348e-07 6.752745129518339 0.5631191618459895 VVFVFGPDKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVFVFGPDKK 10 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 63517000.0 15603000.0 31237000.0 16677000.0 False True 23670891.73209499 25662513.294205036 13380783.640211234 1.0 1.0841380031074046 0.5652843074799941 24.49661072065324 -6.8653316326269564 1.1585797232656407 1.04647094236333 0.5374854630911036 0.959793633180607 0.04559076291723098 0.14140549057390897 0.35770940137361995 0.03061924059078758 0.07195652152490326 1.3635415218080953e-07 6.8653316326269564 -0.5089854792722265 VVFVFGPDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVFVFGPDKK 10 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 118717000.0 40132000.0 30417000.0 48168000.0 False True 54969884.92652096 29073076.364431918 36791710.45109955 1.0 0.5288909810034044 0.6693066667372428 25.71213812346512 -10.70114036548397 10.172593595718265 1.0003654767263999 0.5990988238703291 0.9157455808178726 0.05732446365515058 0.0004755514652950667 1.3971129447941128e-05 0.05555070131048665 0.018501391088889197 1.990030050416624e-11 10.70114036548397 -0.40126665285607077 VVFVFGPDKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVFVFGPDKK 10 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 76244000.0 31316000.0 25773000.0 19155000.0 False True 26040641.53402728 25634155.73346006 23160221.937286723 1.0 0.9843903307821329 0.8893875332150818 24.634261655209666 -6.9355367500450225 0.6998808919972641 1.0011918966877698 0.8668175786544907 0.9975184639461664 0.0024350091060455744 0.08986360342596834 0.06433837863073236 0.002296645828720688 0.00835004589866539 1.1600140514829528e-07 6.9355367500450225 -0.13437431803327904 VVFVFGPDKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVFVFGPDKK 10 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 62720000.0 15603000.0 29551000.0 17566000.0 False True 20198391.08111147 27906460.872583263 14369168.242380613 1.0 1.3816180091037051 0.7114016252422177 24.26773704274569 -6.752271672379544 1.6416281240303872 1.2237822518411132 0.7098502922411285 0.6586218290123464 0.1603788586353988 0.29609396654904346 1.570681588131581 0.07715594808306789 0.1868552023316293 1.7690020150930317e-07 6.752271672379544 -0.5139319595999847 VVFWLHDSFPKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVFWLHDSFPKPR 13 1 Q03111 Q03111 MLLT1 Protein ENL 0 3485690.0 989220.0 922870.0 1573600.0 False True 1354961.3666653314 882094.551877019 1201948.0893092956 1.0 0.6510108506251543 0.8870718522900666 20.369820286648768 -10.060752344190147 5.132002087614217 1.0000034939227551 0.7690413514568913 0.5606939597994914 0.09637150037739184 3.852651389034372e-06 7.049981434375392e-07 0.09331271515828747 0.03110376800052863 8.694560940462978e-11 10.060752344190147 -0.23096214246586377 VVGAQSLK(ub)EMVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVGAQSLKEMVSK 13 1 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 33349700.0 8695300.0 16722000.0 7932400.0 True False 11399622.505404986 14227142.78184546 7111631.340953743 1.0 1.2480363077900027 0.623847968437714 23.44248271504038 -6.79889538528912 1.4605565119829511 1.1370450015506346 0.6154781825048847 0.8288738796198414 0.10615154289847421 0.2223397289468716 0.936519211779341 0.057180968760305706 0.13306417899232584 1.5889294506192807e-07 6.79889538528912 -0.5215668190457499 VVGAQSLK(ub)EMVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVGAQSLKEMVSK 13 1 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 57442000.0 14294000.0 20765000.0 22383000.0 True False 13840244.794140033 29056572.788044453 16520220.8243934 1.0 2.099426218266531 1.193636461646117 23.7223661245394 -10.252916865154443 4.447985365098251 0.9996926922439389 1.6465313399637331 0.40451460369002057 0.36978711968512645 261300956.98364162 434.7285546384008 822422.5000814707 0.1265879668253061 5.5857711015800033e-11 10.252916865154443 0.6468386477197943 VVGAQSLK(ub)EMVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVGAQSLKEMVSK 13 1 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 48064000.0 0.0 16330000.0 31734000.0 True False 0.0 13415783.913127646 25461760.990493722 0.0 VVGAQSLK(ub)EMVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VVGAQSLKEMVSK 13 1 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 48468200.0 12031300.0 17873800.0 18563100.0 True False 16479596.743657209 17084076.415247492 14178878.099045128 1.0 1.0366804892736796 0.8603898699464476 23.974177604363497 -6.85241052644791 1.2233196002105644 1.0196232034298764 0.8530047456436437 0.9437466133299428 0.018013527867409396 0.15482952652468965 0.44465297235253554 0.01151443645345088 0.026690768969372794 1.404719054644749e-07 6.85241052644791 -0.16661845778623274 VVGAQSLK(ub)EMVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VVGAQSLKEMVSK 13 1 P52209-2;P52209;K7EM49;K7EPF6;K7EMN2 P52209-2 PGD 6-phosphogluconate dehydrogenase, decarboxylating 1 62133760.0 16441200.0 43780900.0 1911660.0 True False 13671586.268656563 43545043.60187179 2311379.2674828274 1.0 3.185076167913523 0.1690644539750218 23.704677307971572 -6.712358612551868 1.7865448613859534 2.3400928136937003 0.17557698156300486 0.4763491491393692 0.9204502064271404 0.37038738421095574 2.3058311097237856 0.4097548611952158 1.0381018058543907 1.9392838799191485e-07 6.712358612551868 -2.164515832130695 VVGCSCVVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVGCSCVVVK 10 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 84112000.0 34086000.0 25615000.0 24411000.0 False True 44687076.089293584 21793341.846487947 21885183.88684655 1.0 0.4876878004490729 0.48974302644271556 25.413354315355807 -9.978905274930474 6.724304112311713 1.000000069584296 0.48871541344589137 0.9999878809010825 0.0008390424984317997 8.746658872063227e-10 1.332214626104997e-10 0.0008123995147423758 0.00027079980193069384 1.0497713719767475e-10 9.978905274930474 -0.5112846561384048 VVGCSCVVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVGCSCVVVK 10 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 17198600.0 10177000.0 3860200.0 3161400.0 False True 9853936.705608165 5401597.990677063 2333334.5000329367 1.0 0.548166499547623 0.23679211362347877 23.23226877419951 -8.196305962189797 0.2628400599915344 1.182384921637715 5.268809629717765e-20 0.9993974137608214 0.0076915622165565425 0.08923577982303166 0.05720538626085041 0.08709368268934675 0.10072811442897334 6.363470539226798e-09 8.196305962189797 -1.182384921637715 down VVGCSCVVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVGCSCVVVK 10 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 75959000.0 11614000.0 52283000.0 12062000.0 False True 17619287.09713205 42952690.16105649 9677940.413037585 1.0 2.43782225264086 0.5492810441015458 24.070652216038575 -6.703171754332576 1.8194445777003614 1.890035658414983 0.5545311378206492 0.43269051086810195 0.6065773045262199 0.3889632620776065 2.505420995293818 0.26574283205316973 0.6807862946317192 1.9807435284847016e-07 6.703171754332576 -1.3355045205943339 VVGCSCVVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVGCSCVVVK 10 0 P25398 P25398 RPS12 40S ribosomal protein S12 0 72358000.0 34086000.0 15853000.0 22419000.0 False True 46688515.33951446 15152562.041139474 17124093.933798388 1.0 0.3245458102694309 0.3667731520112302 25.4765643768787 -9.990195211965785 6.503406796508142 1.0000001772688765 0.34565948114032213 0.9968862283058967 0.017239240076953332 4.4316977381558275e-08 6.884234961661663e-09 0.016691826906790077 0.005563940809938149 1.0228331334601044e-10 9.990195211965785 -0.6543406961285543 VVGFHVLGPNAGEVTQGFAAALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVGFHVLGPNAGEVTQGFAAALK 23 0 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 10562200.0 4962600.0 4430400.0 1169200.0 False True 6506016.6578867575 3769401.5895639355 1048222.399758346 1.0 0.5793716474725855 0.16111584935579043 22.6333430855581 -7.718381627544195 0.3942184580823991 1.048878764614254 1.4330257877627647e-24 0.9983395722700753 0.01395522666127149 0.1183454385187836 0.06396403704928871 0.029667099544607743 0.07654759586448362 1.9125745499598095e-08 7.718381627544195 -1.048878764614254 down VVGFHVLGPNAGEVTQGFAAALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVGFHVLGPNAGEVTQGFAAALK 23 0 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9 Q16881 TXNRD1 Thioredoxin reductase 1, cytoplasmic 0 17242300.0 4962600.0 3727700.0 8552000.0 False True 6797407.329222382 3562997.888144554 6532193.733968677 1.0 0.5241701306948392 0.9609831245343295 22.69655314708099 -10.46229870168223 8.921028997213117 1.000004109595729 0.7425766276145844 0.3165041812193645 0.17832815798737386 1.4576056029310588e-05 8.785257504603016e-07 0.17266825347784168 0.05755516550374534 3.4490643590623544e-11 10.46229870168223 -0.2574274819811446 VVGK(ub)DLTVSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVGKDLTVSGR 11 1 Q14657 Q14657 LAGE3 EKC/KEOPS complex subunit LAGE3 1 55033900.0 9235300.0 20269600.0 25529000.0 True False 12107567.734772421 17245454.69028195 22887503.971459832 1.0 1.4243533522223242 1.8903469691710162 23.52940573821008 -6.969922492546895 0.2600299072332924 0.8692196869737089 2.459306517783125 0.999981771999466 0.001552417167678219 0.07632785909774618 0.009120055237878193 0.009725851246683329 0.04396525560904296 1.071710553681075e-07 6.969922492546895 1.5900868308094163 VVGK(ub)DLTVSGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVGKDLTVSGR 11 1 Q14657 Q14657 LAGE3 EKC/KEOPS complex subunit LAGE3 1 88573600.0 20333400.0 18095500.0 50144700.0 True False 19687927.346940447 25321127.51678588 37010298.761245534 1.0 1.2861245915111956 1.8798473861189369 24.23080790324773 -6.959318426444718 0.4449422682764963 0.979832360201945 2.2094787149445296 0.999744059814931 0.005862354585417946 0.07994559892191436 0.02203840011543117 0.007878557225319445 0.04915005575428324 1.0982003393057418e-07 6.959318426444718 1.2296463547425847 VVGK(ub)DLTVSGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVGKDLTVSGR 11 1 Q14657 Q14657 LAGE3 EKC/KEOPS complex subunit LAGE3 1 157510000.0 44002400.0 71695400.0 41812200.0 True False 66754857.80634089 58900795.71128306 33548000.34306175 1.0 0.8823447108846693 0.5025551914197187 25.992369490945965 -6.94979347483136 0.5611074921412307 1.0049386431503284 0.36177600847319574 0.9991849679913254 0.006060097547810931 0.08356880074139812 0.03630655830048104 0.006487423983579242 0.03157844551313419 1.1225521478356279e-07 6.94979347483136 -0.6431626346771326 VVGK(ub)DLTVSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVGKDLTVSGR 11 1 Q14657 Q14657 LAGE3 EKC/KEOPS complex subunit LAGE3 1 49634300.0 9235300.0 13091000.0 27308000.0 True False 12649839.984598296 12512596.33385207 20858412.825914014 1.0 0.9891505623064539 1.6489072471517423 23.59261579973297 -6.903165540262822 0.9410706517217907 0.9749004616445437 1.7227813511703738 0.9880753968598273 0.03368671105996955 0.10911205939347551 0.16458394832720605 0.02667973183753186 0.07058360607179462 1.2497825591203446e-07 6.903165540262822 0.7478808895258301 VVGK(ub)DLTVSGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVGKDLTVSGR 11 1 Q14657 Q14657 LAGE3 EKC/KEOPS complex subunit LAGE3 1 65996400.0 20333400.0 32062000.0 13601000.0 True False 16908123.02235247 31889275.642191257 16444906.216081303 1.0 1.88603286124863 0.9726038895234678 24.011213178682006 -6.6532291659603615 1.9984115912086857 1.5735133219674222 0.9765458846530775 0.20678907417459913 0.3778780584718099 0.5005944795065796 3.8361040799008665 0.1532119801334781 0.4182682744107212 2.2221370170268854e-07 6.6532291659603615 -0.5969674373143448 VVGK(ub)DLTVSGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVGKDLTVSGR 11 1 Q14657 Q14657 LAGE3 EKC/KEOPS complex subunit LAGE3 1 159324400.0 44002400.0 101027000.0 14295000.0 True False 56961974.21697748 95404758.64012972 11693456.679086337 1.0 1.6748850430765863 0.20528531252347482 25.763495813038414 -6.78180466523131 1.5286018481915222 1.3812253837626918 0.1929178427547397 0.773846536178497 0.2856312824597117 0.24775345399647997 1.1435184140896077 0.14715034746832156 0.34672754747907597 1.652704976344354e-07 6.78180466523131 -1.188307541007952 VVGLLAGTLGVAQHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVGLLAGTLGVAQHR 15 0 Q9BQC3;Q9BQC3-3;H0YCR5 Q9BQC3 DPH2 Diphthamide biosynthesis protein 2 0 9266000.0 3004300.0 2741300.0 3520400.0 False True 3938666.3936825804 2332308.72550371 3156142.7780613075 1.0 0.5921569618702955 0.8013226972265535 21.90927579471432 -10.078834808348248 4.81858945770749 1.000011043289056 0.6967398295449689 0.737034213358602 0.0853915538947134 1.0130941045722185e-05 1.9366791147525365e-06 0.0826830264030474 0.02756000551005691 8.339983504427666e-11 10.078834808348248 -0.30327121374408716 VVGLLAGTLGVAQHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVGLLAGTLGVAQHR 15 0 Q9BQC3;Q9BQC3-3;H0YCR5 Q9BQC3 DPH2 Diphthamide biosynthesis protein 2 0 9262600.0 3750800.0 1833600.0 3678200.0 False True 3631732.9070841176 2565766.042097683 2714769.076365269 1.0 0.7064853357175187 0.7475134173743327 21.792226673991994 -10.40650969889391 4.987621494881224 1.0002992668800756 0.7269993765458937 0.9833428225653644 0.016749644197516973 5.5799480856433975e-05 6.639729087710786e-06 0.016235357969135625 0.005405924419307726 3.921843877658193e-11 10.40650969889391 -0.2732998903341819 VVGLLAGTLGVAQHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVGLLAGTLGVAQHR 15 0 Q9BQC3;Q9BQC3-3;H0YCR5 Q9BQC3 DPH2 Diphthamide biosynthesis protein 2 0 11779000.0 3004300.0 3064300.0 5710400.0 False True 4115070.8981547556 2928909.0937149855 4361721.129379641 1.0 0.7117517938824193 1.059938270160907 21.97248585623721 -6.686915789470046 1.8776526772590916 0.818760084997776 1.0586817264157273 0.35584730308194124 0.12198725224377831 0.4233645884159515 2.89149662995898 0.05202391023331678 0.1359890258355175 2.056289275750534e-07 6.686915789470046 0.23992164141795136 VVGLLAGTLGVAQHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVGLLAGTLGVAQHR 15 0 Q9BQC3;Q9BQC3-3;H0YCR5 Q9BQC3 DPH2 Diphthamide biosynthesis protein 2 0 4922700.0 3750800.0 1171900.0 0.0 False True 3118956.3886137884 1165586.7420960637 0.0 1.0 0.37371049699547276 0.0 21.57263194942627 -8.390873445903654 0.5240298572895689 1.0410754752930018 6.592711695218185e-20 0.9926981105980556 0.035254235421680685 0.17928806019258095 0.18026422998094793 0.06785564858990484 0.06916324324904109 4.065617846499845e-09 8.390873445903654 -1.0410754752930018 VVGLPLTGLNTQTQQLLMTVK(ub)ER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVGLPLTGLNTQTQQLLMTVKER 23 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 95141000.0 18380000.0 29095000.0 47666000.0 True False 27883803.757989217 23902769.92972741 38244794.20725004 1.0 0.8572277346801664 1.3715773694000486 24.73292404351228 -6.832667128183819 1.3160889355848926 0.9238440575264222 1.3861737199516737 0.911079080952382 0.06464807916845018 0.17754388614869984 0.6005053780034626 0.03855847429875184 0.08872730923329786 1.4700525908098537e-07 6.832667128183819 0.46232966242525153 VVGLPLTGLNTQTQQLLMTVK(ub)ER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVGLPLTGLNTQTQQLLMTVKER 23 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 28866900.0 7659500.0 7574400.0 13633000.0 True False 6369213.623383634 7533595.203799306 16483597.268130021 1.0 1.1828140252889017 2.5880113688780844 22.602683830082423 -6.93084808673385 0.7398012262762552 0.979289776543671 2.8828184822712064 0.9967022777062746 0.04074031355364397 0.09219977029689967 0.07554119340531246 0.037305426984750374 0.1265582672292609 1.172605463262453e-07 6.93084808673385 1.9035287057275354 up VVGLPLTGLNTQTQQLLMTVK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVGLPLTGLNTQTQQLLMTVKER 23 1 P59045;P59045-3;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 66926000.0 18380000.0 17958000.0 30588000.0 True False 23793272.32396518 16958621.513649307 25021297.859383944 1.0 0.712748598962916 1.0516123011033613 24.50405036560473 -6.682027884997056 1.8942828606168673 0.8185919738265297 1.0503571961093725 0.33364912784622214 0.12168905863874478 0.43400948602371486 3.012614803826406 0.05150945789039297 0.1355206872678059 2.0795631591021223e-07 6.682027884997056 0.2317652222828428 VVGPCWTCGCGTDTNFEVK(ub)TR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVGPCWTCGCGTDTNFEVKTR 21 1 I3L161;I3L3X5;Q9NRY6 I3L161 TMEM256-PLSCR3;PLSCR3 Phospholipid scramblase 3 1 19085900.0 3052200.0 7594600.0 8439100.0 True False 4630410.54570918 6239284.293119373 6771108.186011071 1.0 1.3474581209437408 1.4623127083808136 22.142708682032307 -12.407243751471823 0.17677428131672243 5.7642937820517314e-11 1.5646549690430718 0.9994778909970488 0.004490877360397798 6.406407938675677 0.11966914770529445 2.375433553362427 0.0875315976022411 3.9152207033730917e-13 12.407243751471823 1.5646549689854288 VVGSEFVQK(ub)YLGEGPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVGSEFVQKYLGEGPR 16 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 15390900.0 4224600.0 5684100.0 5482200.0 True False 5538491.511084593 4836054.436448263 4914954.532975711 1.0 0.8731717701055439 0.8874175437732547 22.40106166007108 -10.801100577870844 7.001545859232834 1.0048474139708417 0.8802946569393995 0.9894896313744922 0.005815812746178024 0.0004551413445332091 1.2929612158036592e-05 0.0058240625666695555 0.0018770454925506903 1.5808818818511308e-11 10.801100577870844 -0.1245527570314422 VVGSEFVQK(ub)YLGEGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVGSEFVQKYLGEGPR 16 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 26102700.0 7061800.0 9209800.0 9831100.0 True False 6837627.024433894 12887321.168472517 7256039.983321892 1.0 1.8847651564527232 1.061192714576683 22.705064298811617 -10.448380729628193 4.391124864300257 0.9982109938227047 1.472978935515532 0.30544126079221734 0.3362220414724802 0.005908972277613016 0.0007422914834739141 0.3266686309332786 0.1085151972704176 3.5613878306503876e-11 10.448380729628193 0.4747679416928273 VVGSEFVQK(ub)YLGEGPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVGSEFVQKYLGEGPR 16 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 60694000.0 14572000.0 13721000.0 32401000.0 True False 22106789.355898716 11272380.347337699 25996928.14813722 1.0 0.5099058106477099 1.1759703197787292 24.397986177078664 -6.709519778885284 1.796721247732024 0.6985560287866829 1.174396380085477 0.4628942307566777 0.2065384266991882 0.37605016724880563 2.366083035038047 0.09148491809990657 0.2325671376323747 1.9520018328458214e-07 6.709519778885284 0.4758403512987942 VVGSEFVQK(ub)YLGEGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVGSEFVQKYLGEGPR 16 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 17579100.0 4224600.0 5923400.0 7431100.0 True False 5786548.785522282 5661684.601935626 5676027.228308534 1.0 0.9784216485136942 0.980900263471334 22.46427172159397 -10.678270342062524 6.637455603542459 1.0001488891258274 0.979660955997556 0.9889840551858885 0.001011890319174634 2.245782797196435e-06 1.0885684639396581e-07 0.000986928568450396 0.0003265861961959874 2.0976337303370212e-11 10.678270342062524 -0.020487933128271463 VVGSEFVQK(ub)YLGEGPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVGSEFVQKYLGEGPR 16 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 25371200.0 7061800.0 9629400.0 8680000.0 True False 5872199.590784066 9577524.510913752 10494947.868214512 1.0 1.6309943766122814 1.787226014028111 22.485469574245894 -11.265053597469489 0.25490631870156666 1.0635476049971869e-10 1.857430426437436 0.9992729364787875 0.009176107712332675 3.463240123535557 0.1388643900063064 2.0299703288975968 0.06978479545287215 5.43183291620504e-12 11.265053597469489 1.8574304263310812 VVGSEFVQK(ub)YLGEGPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVGSEFVQKYLGEGPR 16 1 P43686;P43686-2 P43686 PSMC4 26S protease regulatory subunit 6B 1 55785000.0 14572000.0 17882000.0 23331000.0 True False 18863741.25706312 16886850.980458684 19084997.39627589 1.0 0.8952015801285319 1.0117291758934577 24.169112499171113 -13.803452672013545 16.999646084449193 8.867627390361308 0.9581188402098955 0.0 0.05349978583637645 0.0 0.0 0.0 0.01564125793008428 1.57234313191785e-14 13.803452672013545 -7.909508550151413 VVGVLLGSWQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVGVLLGSWQK 11 0 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 65914000.0 23981000.0 23262000.0 18671000.0 False True 31439323.23233438 19791400.274565816 16739104.024878623 1.0 0.6295110148621447 0.5324257109855014 24.90606682646888 -13.999999999999998 0.18800579122172176 2.972554500535801 0.4613607875433349 0.9994906287102564 0.00454703612306016 12.318916827466921 0.1374985512665844 8.89607101278001 0.06784101389835864 1.0000000000000041e-14 13.999999999999998 -2.511193712992466 VVGVLLGSWQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVGVLLGSWQK 11 0 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 62437900.0 26787000.0 9304900.0 26346000.0 False True 25936661.34746248 13020395.094412465 19445192.23694177 1.0 0.5020073678714365 0.7497183996213991 24.62848944729175 -10.142070389051055 5.280610026653393 1.000011031611604 0.6258628837462057 0.7525764660872816 0.10112760524170755 1.3134379260577006e-05 2.1339040853177495e-06 0.0979192677507925 0.03263879424514006 7.209906138757106e-11 10.142070389051055 -0.3741481478653983 VVGVLLGSWQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVGVLLGSWQK 11 0 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 60352000.0 14842000.0 21607000.0 23903000.0 False True 22516399.09554274 17751062.033738475 19178561.57294293 1.0 0.7883614941455007 0.8517597104032254 24.42447278903717 -9.990088727119792 6.388158371116383 1.000000063628709 0.8200606022743591 0.9148270238203686 0.02588221340568862 2.3474576973473338e-08 3.6827509469376854e-09 0.025060354333056527 0.008353448456932769 1.0230839530927076e-10 9.990088727119792 -0.1799394613543499 VVGVLLGSWQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVGVLLGSWQK 11 0 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 89136000.0 23981000.0 25391000.0 39764000.0 False True 32847423.762157377 24269141.66319132 30372562.165286493 1.0 0.7388445997750099 0.9246558386194627 24.96927688799177 -9.903927019779704 5.4293736381414135 1.0000001883497167 0.831750219515521 0.5222649587100858 0.07585712061038082 1.7294578742351294e-07 3.487381424188928e-08 0.07344842328701542 0.02448278040081346 1.247593146132669e-10 9.903927019779704 -0.16824996883419574 VVGVLLGSWQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVGVLLGSWQK 11 0 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 51245000.0 26787000.0 10169000.0 14289000.0 False True 22274577.365308087 10114217.57861153 17276763.835128706 1.0 0.45407001052078716 0.7756270097423572 24.408894722726025 -10.284204331341929 5.907978215848663 1.0000227366441516 0.6148485101315796 0.6566962379820801 0.13127509521890074 3.931650931503116e-05 4.763559068500883e-06 0.12711405462057415 0.04236885479621555 5.1975140100451466e-11 10.284204331341929 -0.38517422651257205 VVGVLLGSWQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVGVLLGSWQK 11 0 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 71303000.0 14842000.0 32592000.0 23869000.0 False True 19213261.579558805 30778226.549329452 19525086.916622043 1.0 1.601926170727553 1.0162296930051165 24.19559911112962 -10.243506021660432 4.822661419449621 0.9999305369778777 1.3090779318668895 0.2707670397280969 0.23910958576280242 0.00017862257434539966 2.8019788805002593e-05 0.23156875610414962 0.07717228696455207 5.708131615724386e-11 10.243506021660432 0.3091473948890118 VVGVLLGSWQKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVGVLLGSWQKK 12 1 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 1 16097100.0 5565200.0 8245800.0 2286100.0 True False 4627710.3801624905 8201378.238736841 2764112.9402678804 1.0 1.7722323924793388 0.5972960088679589 22.141867147214295 -6.72943134084194 1.7252669622756025 1.4650395917707402 0.598076331900562 0.5565400348719083 0.32464612068478227 0.33735903317558225 1.966984670307643 0.14913195981363556 0.3703044964340696 1.8645269246408906e-07 6.72943134084194 -0.8669632598701782 VVHLGVGTPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVHLGVGTPGR 11 0 C9J384;Q9BQ75-2;Q9BQ75 C9J384 CMSS1 Protein CMSS1 0 5147800.0 1448500.0 1688700.0 2010600.0 False True 1898997.5272939515 1436752.5425010445 1802562.3990370608 1.0 0.7565847358150063 0.9492178758156101 20.85680659626336 -9.911146660952127 5.560685660931527 1.000000129669421 0.8529013059915205 0.43740867530883143 0.07864215009334913 107436304.84863499 67.80013824247747 178.40760445363568 0.026921299735291948 1.2270247957433532e-10 9.911146660952127 -0.1470988236779005 VVHLGVGTPGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVHLGVGTPGR 11 0 C9J384;Q9BQ75-2;Q9BQ75 C9J384 CMSS1 Protein CMSS1 0 2880040.0 1216900.0 1160000.0 503140.0 False True 1178270.1755973818 1623194.049320088 371352.5401235444 1.0 1.3776076853486767 0.31516756327577333 20.168238954250608 -6.810613972007668 1.4118994312493867 1.2056427349566503 0.2963082644342516 0.8614418718258545 0.1636871361342137 0.2059610233576907 0.8090841857033608 0.09115563614637795 0.21080871587045005 1.546628568569862e-07 6.810613972007668 -0.9093344705223987 down VVHLGVGTPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVHLGVGTPGR 11 0 C9J384;Q9BQ75-2;Q9BQ75 C9J384 CMSS1 Protein CMSS1 0 4237280.0 1448500.0 974780.0 1814000.0 False True 1984049.5942406429 931710.9964336037 1385570.560502708 1.0 0.4696006587427056 0.6983548014751156 20.920016657786253 -10.308324698208208 5.745968591919047 1.0000441338708064 0.5839777301089095 0.8151555094887442 0.09338848770704215 5.2805086811072396e-05 6.356662691126561e-06 0.09043257462367689 0.03014100480140452 4.916718021420937e-11 10.308324698208208 -0.41606640376189685 VVHLSLRPIFLQPGRPLTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVHLSLRPIFLQPGRPLTR 19 2 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 0 136034000.0 21978000.0 47081000.0 66975000.0 False True 33342232.807023276 38679027.704468004 53737361.8938147 1.0 1.1600611131333884 1.611690560882154 24.9908473837656 -6.952820314649127 0.5269738053029198 0.9927187936931637 1.7994291784041263 0.9994044226785541 0.006320881849644821 0.08237265259900105 0.0314256791732909 0.007083788650628685 0.03733325092962635 1.1147556581014619e-07 6.952820314649127 0.8067103847109626 VVHLSLRPIFLQPGRPLTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVHLSLRPIFLQPGRPLTR 19 2 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 0 67273600.0 13140000.0 24755000.0 29378600.0 False True 17998213.09514813 23661242.24616209 22439979.751259618 1.0 1.314643966102422 1.246789313618521 24.101350343725542 -10.129803981512666 4.524746061277358 0.9999683894272441 1.2807166398090029 0.9580184838222141 0.027701545906991115 9.061532793575445e-06 1.7426525364823747e-06 0.026825001181992124 0.008940635492515163 7.416449066398314e-11 10.129803981512666 0.28074825038175877 VVHLSLRPIFLQPGRPLTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVHLSLRPIFLQPGRPLTR 19 2 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 0 47941400.0 12984700.0 13819900.0 21136800.0 False True 10797353.369743371 13745449.455664622 25556407.15447885 1.0 1.2730387702399815 2.366914027848129 23.364174388797178 -6.944838366215711 0.6128987680967005 0.9879468299874314 2.7092558046591764 0.9987314215146528 0.021036442228646604 0.08562698987291925 0.045067191091252255 0.021324782463300922 0.09233344266193236 1.1354333175556297e-07 6.944838366215711 1.721308974671745 up VVHLSLRPIFLQPGRPLTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVHLSLRPIFLQPGRPLTR 19 2 A0A3B3IUD7;Q14690 A0A3B3IUD7 PDCD11 Protein RRP5 homolog 0 111344000.0 21978000.0 39119000.0 50247000.0 False True 28450954.251148388 36941993.26163536 41102561.57775805 1.0 1.298444788021275 1.4446813001394847 24.76197370585805 -12.201124540140492 0.1114539855192746 6.599309461802364e-17 1.7354106758973007 0.9997931022280709 0.002661760870805523 6.133185298741034 0.08296770151786499 1.648404520672553 0.22369276255770792 6.29325688856447e-13 12.201124540140492 1.7354106758973007 VVIDAFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVIDAFR 7 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 4458100.0 1091100.0 1368700.0 1998300.0 False True 1430442.6662274315 1164495.2951508134 1791535.0850471312 1.0 0.814080370115069 1.2524340383190782 20.44803024328237 -6.791476546820054 1.4904967946936631 0.8962891269441938 1.25728327264366 0.8060556106633309 0.0791129911137423 0.23315571905923144 1.0232477534880438 0.04177595250766713 0.09770069298225623 1.6163055090033322e-07 6.791476546820054 0.3609941456994662 VVIDAFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVIDAFR 7 0 O00487 O00487 PSMD14 26S proteasome non-ATPase regulatory subunit 14 0 5407200.0 1091100.0 1952200.0 2363900.0 False True 1494509.155868809 1865945.3489378947 1805595.5060487057 1.0 1.2485339026599387 1.208152856714385 20.511240304805263 -10.087581477410792 4.635904346811391 0.9999865505963251 1.2283433796928869 0.9770823148566986 0.016485492993990318 2.2917463369836504e-06 4.5103811033031407e-07 0.01596294965632792 0.005320669982213891 8.173696779188615e-11 10.087581477410792 0.22835682909656174 VVIFQQEQENK(ub)IQSHSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVIFQQEQENKIQSHSR 17 1 P63151-2;P63151;E5RIY1 P63151-2 PPP2R2A Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform 1 31597000.0 16069000.0 9071500.0 6456500.0 True False 20801637.26734475 8566663.050510615 5281483.2492844295 1.0 0.4118263836836973 0.2538974784247159 24.31019374952591 -13.99999999999995 0.18454509967245142 4.095842436978976 0.13416201688213567 0.9994933551975058 0.007226052418446053 12.266936811373064 0.136214212928923 13.6330691826215 0.11351386793489146 1.0000000000001145e-14 13.99999999999995 -3.9616804200968403 VVIGMDVAASEFFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVIGMDVAASEFFR 14 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 11362800.0 3546400.0 4253500.0 3562900.0 False True 4649364.743386459 3618894.380013137 3194245.2857500985 1.0 0.778363191479196 0.687028327965404 22.148602179270863 -13.999999999999998 0.12177731922668185 2.0551250386028848 0.544683140970165 0.9996842657352368 0.0023349974930543154 11.95730152312319 0.1076229974534167 3.046389552852411 0.12633615994054823 1.0000000000000041e-14 13.999999999999998 -1.5104418976327199 VVIGMDVAASEFFR ddPTM_RPMI8226_Bortezomib_2h_R1 2 VVIGMDVAASEFFR 14 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 56583900.0 26418300.0 9520400.0 20645200.0 False True 25579665.52714631 13321945.36823012 15237602.777275903 1.0 0.5208021721039418 0.5956920258048356 24.608494064260558 -10.695200502520052 6.772101356943888 1.0038110646715148 0.5582470989544276 0.978899795686309 0.030573654746478718 0.0017681424646598372 7.958064085507828e-05 0.02975303428179053 0.009867604638817288 2.0174347512465456e-11 10.695200502520052 -0.44556396571708723 VVIGMDVAASEFFR ddPTM_RPMI8226_Bortezomib_8h_R1 2 VVIGMDVAASEFFR 14 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 625159700.0 143659000.0 257419700.0 224081000.0 False True 217941205.8797047 211481143.30570388 179791292.13180885 1.0 0.9703586912446169 0.8249531859112812 27.699363749945174 -6.940231836448498 0.6574034502442968 1.0016258587330342 0.7854731101297406 0.9981940978722337 0.003250700477870782 0.08766104830147838 0.054129271676776475 0.0031698962150560747 0.012502033730628127 1.1475408740775296e-07 6.940231836448498 -0.2161527486032936 VVIGMDVAASEFFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVIGMDVAASEFFR 14 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 16691500.0 3546400.0 4712200.0 8432900.0 False True 4857599.917856426 4503999.422838415 6441222.701027173 1.0 0.9272067479830557 1.3260093070549894 22.211812240793755 -6.859623501460597 1.1876239957966885 0.9605435180610002 1.3451837724721976 0.9531801110830804 0.037521259730034784 0.1471933681065693 0.3947086420888349 0.02464493050325714 0.057504944332789756 1.381581466089079e-07 6.859623501460597 0.3846402544111973 VVIGMDVAASEFFR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VVIGMDVAASEFFR 14 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 45898200.0 26418300.0 8454600.0 11025300.0 False True 21967986.979128636 8409053.391693301 13330639.254772507 1.0 0.3827867068422146 0.6068211560502877 24.388899339694834 -10.164745287739285 5.325192970134998 1.0000180122281892 0.4948039314460935 0.8714651299836127 0.09146168089482096 1.9559603432753422e-05 3.068041103352283e-06 0.08856054518777165 0.02951913057672651 6.843128768229418e-11 10.164745287739285 -0.5052140807820957 VVIGMDVAASEFFR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VVIGMDVAASEFFR 14 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 373166000.0 143659000.0 143712000.0 85795000.0 False True 185969407.44224772 135714300.86699915 70181190.33103976 1.0 0.7297668080657022 0.3773802976322024 27.470490072037624 -6.967479477487035 0.3125849315824822 1.0526572591990664 0.04324641386765767 0.9999555136402167 0.0017002575710675105 0.0771293358070048 0.011943344213627333 0.00551155799646504 0.03120783622887907 1.0777561816787754e-07 6.967479477487035 -1.0094108453314088 down VVIIGAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVIIGAGK 8 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 5499800.0 1634500.0 1386100.0 2479200.0 False True 2142845.3285205145 1179299.2829754816 2222676.166165661 1.0 0.5503426996243848 1.0372545962989612 21.031096288760224 -11.987410953377205 14.45019276314149 0.8985131399547333 0.8144187832712041 0.0 0.22644525867158535 0.0 0.0 0.0 0.06589544663735902 1.0294115734570491e-12 11.987410953377205 -0.08409435668352916 VVIIGAGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVIIGAGK 8 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 5057100.0 1634500.0 1424800.0 1997800.0 False True 2238818.8207016448 1361847.6248164698 1525960.7859825317 1.0 0.6082884475616779 0.6815919054603518 21.094306350283116 -10.788076224642193 7.109276481245054 1.0110580059903282 0.6449401765110148 0.9690228709538268 0.029926011372223366 0.005236965063081366 0.00015611098618487603 0.02893085220441804 0.009658578638586246 1.629010093917998e-11 10.788076224642193 -0.3661178294793135 VVIIGAGKPAAVVLQTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVIIGAGKPAAVVLQTK 17 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 159238000.0 60256000.0 47806000.0 51176000.0 False True 78996199.51993398 40673531.146328494 45880798.43485553 1.0 0.514879594126106 0.5807975410675031 26.235279911607186 -10.46976684373028 6.1050079717722046 1.000261948472355 0.5478385675969516 0.9843103360394658 0.026910889149713166 9.600140664217568e-05 8.337902863498283e-06 0.026071095979560845 0.008685452125706058 3.390261175814547e-11 10.46976684373028 -0.45242338087540335 VVIIGAGKPAAVVLQTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVIIGAGKPAAVVLQTK 17 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 137823000.0 46961000.0 24579000.0 66283000.0 False True 45470248.76015173 34393522.8777917 48921493.8526233 1.0 0.7563961890600603 1.0759011702503836 25.43841956105967 -6.702898189137965 1.8203518901025906 0.8491636228974659 1.0750094885885255 0.4313924244241242 0.10277479672154276 0.389541945920241 2.51145164713913 0.045005804773390126 0.11533860051374023 1.9819916060191743e-07 6.702898189137965 0.22584586569105958 VVIIGAGKPAAVVLQTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVIIGAGKPAAVVLQTK 17 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 194441000.0 41532000.0 87656000.0 65253000.0 False True 63007080.39590911 72013101.940546 52355715.94859415 1.0 1.1429366586746597 0.8309497221520754 25.90901062422249 -6.782104196995203 1.5273996768402658 1.080711307061421 0.8283006893538317 0.7748728066173991 0.06050360766371082 0.24730765890789677 1.1396754545938423 0.03119353325793365 0.07348367541927225 1.6515655030525208e-07 6.782104196995203 -0.2524106177075892 VVIIGAGKPAAVVLQTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVIIGAGKPAAVVLQTK 17 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 167712000.0 60256000.0 45446000.0 62010000.0 False True 82534271.5571724 43438045.450174935 47364515.13603808 1.0 0.5263031299680754 0.5738769391479775 26.298489973130078 -10.383976381449006 9.070360239266888 1.0000011629725902 0.5500900350627206 0.9916839097200174 0.0194219262685491 4.567630218616912e-07 3.101769137370429e-08 0.018805247714209602 0.006268399749113253 4.130699656620992e-11 10.383976381449006 -0.44991112790986965 VVIIGAGKPAAVVLQTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVIIGAGKPAAVVLQTK 17 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 83829000.0 46961000.0 19767000.0 17101000.0 False True 39050152.22504319 19660511.24755769 20676740.033909738 1.0 0.5034682357767926 0.529491918872715 25.218824836493948 -10.591755396406608 6.415418941697728 1.0011623962774185 0.5164800773247543 0.9978321578072707 0.01062412413548365 0.00017700623949939653 1.126376216383692e-05 0.010308445282093383 0.00342892132039737 2.5600273410431194e-11 10.591755396406608 -0.4846823189526642 VVIIGAGKPAAVVLQTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVIIGAGKPAAVVLQTK 17 1 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 180805000.0 41532000.0 87290000.0 51983000.0 False True 53763992.718113326 82432234.76592322 42522627.39062226 1.0 1.5332238287829287 0.7909127510966312 25.68013694631494 -6.713936850174414 1.781392555270909 1.3264896481793242 0.7924625575789561 0.48370237310674813 0.22456431928811013 0.3672040873782908 2.2738816342294212 0.10023347175298615 0.2534108790433417 1.932249260795632e-07 6.713936850174414 -0.5340270906003681 VVINVPIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVINVPIFK 9 0 A0A0C4DGB2;E1CEI4;A0A2R8YEL6;P48506;B4E2I4 A0A0C4DGB2 GCLC Glutamate--cysteine ligase catalytic subunit 0 12990100.0 3873600.0 3602900.0 5513600.0 False True 5078327.111995765 3065361.3639942016 4943105.56218578 1.0 0.6036163674359144 0.9733728161207711 22.275921896104535 -10.509859205509066 8.942580212753935 1.0000087538299591 0.7884945930092391 0.303749560377667 0.15095243806358183 2.6346487595555804e-05 1.4438669474400801e-06 0.14616511543752456 0.04871968989080494 3.091297441807449e-11 10.509859205509066 -0.21151416082072005 VVINVPIFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVINVPIFK 9 0 A0A0C4DGB2;E1CEI4;A0A2R8YEL6;P48506;B4E2I4 A0A0C4DGB2 GCLC Glutamate--cysteine ligase catalytic subunit 0 11579100.0 5221700.0 2368700.0 3988700.0 False True 5055939.991714074 3314534.2626073193 2943939.81156493 1.0 0.6555723105969103 0.5822734874997735 22.26954790978336 -13.999999999999996 0.21747263846632944 3.0556940533126506 0.5421035094727206 0.9994954895919156 0.004090576508878662 12.932114668728017 0.14775354493098614 11.401660990308756 0.04125241394401937 1.0000000000000082e-14 13.999999999999996 -2.51359054383993 VVINVPIFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVINVPIFK 9 0 A0A0C4DGB2;E1CEI4;A0A2R8YEL6;P48506;B4E2I4 A0A0C4DGB2 GCLC Glutamate--cysteine ligase catalytic subunit 0 18834400.0 3873600.0 4972500.0 9988300.0 False True 5305774.600103949 4752798.50814142 7629269.255495709 1.0 0.8957784426138842 1.4379180855791045 22.339131957627426 -6.856885837666585 1.2013106716732473 0.94385508441906 1.462659216250989 0.9497469166332109 0.05265522762138772 0.15004619121406243 0.4132409856231283 0.034226122231982924 0.07963751781654202 1.390318053985626e-07 6.856885837666585 0.5188041318319291 VVINVPIFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVINVPIFK 9 0 A0A0C4DGB2;E1CEI4;A0A2R8YEL6;P48506;B4E2I4 A0A0C4DGB2 GCLC Glutamate--cysteine ligase catalytic subunit 0 9778100.0 5221700.0 1642200.0 2914200.0 False True 4342074.910532322 1633353.1426488226 3523545.7462616027 1.0 0.3761688078404386 0.8114889353278406 22.049953185217635 -10.359424154382975 5.767052938876684 1.0000821240099274 0.5938288715842402 0.5371981029109323 0.17771869785124686 0.00018769401122142293 2.084821476614159e-05 0.1721099753653695 0.057358463090628344 4.3709500710892924e-11 10.359424154382975 -0.4062532524256871 VVISLQLTAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVISLQLTAEK 11 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 48361200.0 28978000.0 9379200.0 10004000.0 False True 28058109.251755264 13124363.471881852 7383652.286433063 1.0 0.4677565175230336 0.2631557322762636 24.741914457737337 -13.685925416478861 0.1370914066186094 3.3336690189745464 4.47846867250162e-20 0.9996232888386328 0.006027867343252256 10.6900717539442 0.11292129505960093 6.784563487428822 0.23117619191002037 2.0609838257389385e-14 13.685925416478861 -3.3336690189745464 VVISLQLTAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVISLQLTAEK 11 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 612480000.0 164580000.0 243650000.0 204250000.0 False True 249679892.40967685 200168753.85386097 163879897.97404492 1.0 0.8017015384059138 0.6563600151875643 27.895504399792678 -6.974518553738138 0.10381724731515488 1.3373016944494045 0.11706491174006126 0.9999996999729877 7.693091126008398e-05 0.07486179288439795 0.0030552421264442866 0.01247763965398239 0.023187001232321702 1.0604286342381778e-07 6.974518553738138 -1.2202367827093432 VVISLQLTAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVISLQLTAEK 11 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 4606900.0 2132400.0 1278500.0 1196000.0 False True 2920805.905943216 1222011.6425658742 913529.4323931866 1.0 0.4183816665391362 0.31276622336812915 21.47793506037832 -13.999999999999998 0.2399399618374979 4.8486373717831714 0.26604201846853165 0.9995248621257496 0.006586452942242281 13.62132994982185 0.15503493973051494 25.117558419718662 0.0516260559476708 1.0000000000000041e-14 13.999999999999998 -4.58259535331464 VVISLQLTAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVISLQLTAEK 11 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 60682000.0 28978000.0 15138000.0 16566000.0 False True 24096490.9430656 15056448.589342253 20029874.00747024 1.0 0.6248398833223119 0.8312361353690947 24.522319733171614 -10.103563694435598 5.138744235675333 1.000006729012166 0.7280380093452092 0.6983411409247683 0.0842609170579686 6.496028511813208e-06 1.1331478955595089e-06 0.08158730032633837 0.027195094041559138 7.878368773576812e-11 10.103563694435598 -0.2719687196669567 VVISLQLTAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVISLQLTAEK 11 0 P30041 P30041 PRDX6 Peroxiredoxin-6 0 498392900.0 164580000.0 199972900.0 133840000.0 False True 213052054.35681093 188844232.32469332 109482493.31436998 1.0 0.8863760215539845 0.5138767314161314 27.666630721885127 -6.949440779763271 0.5649501176745272 1.0047513879328076 0.3775471100386126 0.9991566605891495 0.006029558482211753 0.08371109680770078 0.036897784143075416 0.006425370728074957 0.03099918252295395 1.1234641543912184e-07 6.949440779763271 -0.6272042778941951 VVISLQLTAEKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVISLQLTAEKR 12 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 9887600.0 4765800.0 2516500.0 2605300.0 False True 4614512.287667028 3521351.5733741364 1922893.7726753398 1.0 0.7631037374817429 0.4167057432731429 22.137746745397607 -6.965677586302259 0.34622728204400216 1.034962238222841 0.1332259008933038 0.9999264376701388 0.002054348726523051 0.0777317829216099 0.014053459675537111 0.004802444488243114 0.029849880705707134 1.0822370896960203e-07 6.965677586302259 -0.9017363373295372 down VVISLQLTAEKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVISLQLTAEKR 12 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 628350000.0 126340000.0 239600000.0 262410000.0 False True 191667016.69120574 196841507.99665558 210544548.48161134 1.0 1.0269972966386098 1.0984912903445414 27.514026849103654 -6.9542160568301075 0.5104644057402178 0.9986892214796668 1.129938402197866 0.9994919392476354 0.000936622789291184 0.08183566073371391 0.02928806869366767 0.0010779431191887952 0.005900755065520255 1.1111787902651878e-07 6.9542160568301075 0.13124918071819924 VVISLQLTAEKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVISLQLTAEKR 12 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 5529100.0 1648400.0 1842000.0 2038700.0 False True 2257858.0263350243 1760614.3493205619 1557201.0483444715 1.0 0.7797719470335374 0.6896806753045206 21.10652334190899 -13.999999999999849 0.12291169099064707 2.047797656227309 0.55137298374411 0.9996787811651897 0.0023361614096127858 11.953520867009704 0.10826123000673026 3.048242499990797 0.12277174479983403 1.0000000000003477e-14 13.999999999999849 -1.496424672483199 VVISLQLTAEKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVISLQLTAEKR 12 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 7809700.0 4765800.0 1342100.0 1701800.0 False True 3962973.8607378677 1334869.840914008 2057638.511765838 1.0 0.3368353887313978 0.5192157667632774 21.918152020831883 -10.873834560671368 11.141180062069166 1.0224773302665229 0.4280255777482837 0.9291484464150839 0.07445647754566793 0.03242467570210219 0.00036718420462913184 0.056231956250052596 0.02403072479596986 1.3371047737372098e-11 10.873834560671368 -0.5944517525182391 VVISLQLTAEKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVISLQLTAEKR 12 1 P30041 P30041 PRDX6 Peroxiredoxin-6 0 516320000.0 126340000.0 217710000.0 172270000.0 False True 163549620.53371948 205594247.1175293 140918627.63946885 1.0 1.257075659647534 0.8616261363346622 27.285153171196104 -6.731267369602246 1.718721520519986 1.1544910764016503 0.8618121462189425 0.5650556584235169 0.10805827367242546 0.33388092944216896 1.9328175818330147 0.04981244436611801 0.12342392976329929 1.8566610660101565e-07 6.731267369602246 -0.29267893018270774 VVITGIGLVTPLGVGTHLVWDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVITGIGLVTPLGVGTHLVWDR 22 0 F8VNS3;C9J2G3;C9JQQ2;Q9NWU1-2;Q9NWU1 F8VNS3 OXSM 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial 0 64289000.0 17926000.0 18464000.0 27899000.0 False True 27195052.566143375 15168954.940109542 22384750.42143391 1.0 0.5577836227091619 0.8231184832972864 24.696840878646537 -10.284753111580487 5.8618130361985274 1.0000198648731593 0.6904510530032231 0.6447244246102097 0.10832250323557437 2.8123280092239165e-05 3.4315709341160953e-06 0.10488953517485754 0.03496093758757247 5.190950510488028e-11 10.284753111580487 -0.30956881186993623 VVITGIGLVTPLGVGTHLVWDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVITGIGLVTPLGVGTHLVWDR 22 0 F8VNS3;C9J2G3;C9JQQ2;Q9NWU1-2;Q9NWU1 F8VNS3 OXSM 3-oxoacyl-[acyl-carrier-protein] synthase, mitochondrial 0 45629000.0 17926000.0 10843000.0 16860000.0 False True 23205560.37428728 10239577.518236976 13791652.998208886 1.0 0.44125534367973507 0.5943253589122807 24.467967200738986 -10.55512134243065 9.652596452413942 1.0000244907307838 0.5177903512960965 0.9297365259469256 0.062490572039964214 3.2937080630586314e-05 1.5180058993921252e-06 0.06050929192351977 0.020168745400479693 2.7853428315706552e-11 10.55512134243065 -0.4822341394346873 VVITVQQLSNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVITVQQLSNK 11 0 Q5R372-4;Q5R372;Q5R372-3;A0A0C4DG54;Q5R372-2 Q5R372-4 RABGAP1L Rab GTPase-activating protein 1-like 0 7747800.0 3175300.0 2505400.0 2067100.0 False True 4162849.0496489448 2131604.0859727096 1853216.3210233294 1.0 0.5120541390162752 0.4451798032839101 21.989139814741712 -13.999999999999998 0.2800306984596147 4.977381657342252 0.42505381434593414 0.9996052454070562 0.004913340153295926 15.399863007672314 0.16763294494735645 35.07915699001917 0.026449770163164747 1.0000000000000041e-14 13.999999999999998 -4.552327842996318 VVITVQQLSNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVITVQQLSNK 11 0 Q5R372-4;Q5R372;Q5R372-3;A0A0C4DG54;Q5R372-2 Q5R372-4 RABGAP1L Rab GTPase-activating protein 1-like 0 6606300.0 3175300.0 1221800.0 2209200.0 False True 4349294.219256007 1167816.836047701 1687432.4599021992 1.0 0.26850720534778366 0.38797845692555893 22.052349876264604 -9.974105006098034 5.902560270283641 1.0000005912964547 0.3282428311638359 0.9768270588889002 0.048773934216815605 3.7950886412634597e-07 6.604860484078004e-08 0.047225200956872486 0.015741719579139297 1.0614388856640287e-10 9.974105006098034 -0.6717577601326188 VVIVDPETNK(ub)EMSVQEAYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVIVDPETNKEMSVQEAYK 19 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 9825900.0 2494300.0 4109500.0 3222100.0 True False 3270051.4548355592 3496378.6187055386 2888708.000565659 1.0 1.0692121108783472 0.8833830416625426 21.64088190628669 -6.805876159986389 1.4320770703455405 1.0379078703400664 0.8804384059842801 0.848706137915761 0.029826936006616362 0.2124846498460257 0.8596477533730887 0.01638160307459335 0.03796483479046977 1.5635934411393054e-07 6.805876159986389 -0.15746946435578624 VVIVDPETNK(ub)EMSVQEAYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVIVDPETNKEMSVQEAYK 19 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 12143900.0 2414000.0 2995500.0 6734400.0 True False 2337368.8913567946 4191618.7713261386 4970458.612330549 1.0 1.7933064767080862 2.126518681201965 21.156454012359013 -10.233529282164797 0.19759576086787692 5.803996778509281e-24 2.4218734818371925 0.9994161488674856 0.011417315958716905 1.8377611988088125 0.09567359488585864 1.1500831782184975 0.20590530632568177 5.84077824507001e-11 10.233529282164797 2.4218734818371925 VVIVDPETNK(ub)EMSVQEAYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVIVDPETNKEMSVQEAYK 19 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 7366000.0 2494300.0 2557500.0 2314200.0 True False 3416510.1159229823 2444501.193478469 1767633.622445076 1.0 0.715496547803453 0.5173798883857669 21.704091967809582 -7.861166720560169 0.12508801153132657 1.4047734880658127 6.016185283619852e-11 0.9999817377200743 0.0008464551983372675 0.12463643611356519 0.018020492243754523 0.08296385904067462 0.10559972868222323 1.3766808757913372e-08 7.861166720560169 -1.4047734880056508 VVIVDPETNK(ub)EMSVQEAYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVIVDPETNKEMSVQEAYK 19 1 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 1 8758900.0 2414000.0 3906300.0 2438600.0 True False 2007347.95833254 3885255.9865601547 2948499.985187547 1.0 1.9355169443505709 1.468853455599597 20.93685928779329 -10.25442542561211 4.976087734178465 0.9998630988245583 1.7021851999755846 0.7511695425144528 0.19051457150622206 0.0002894069106096683 4.3362297237339765e-05 0.1845004429494326 0.06148831355420528 5.566402088989011e-11 10.25442542561211 0.7023221011510263 VVK(ub)QASEGPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVKQASEGPLK 11 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 34252600.0 10622800.0 16476900.0 7152900.0 True False 13926593.671341525 14018610.746453142 6412786.5234617535 1.0 1.0066072922986884 0.46047056981766743 23.73133909412401 -6.904161892548978 0.9345757720170216 1.0201869857842243 0.3980407504970497 0.988525716736721 0.02741239283084394 0.10840647900168336 0.16064385343837762 0.021814251970288773 0.058039284352911114 1.246918612037993e-07 6.904161892548978 -0.6221462352871746 down VVK(ub)QASEGPLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVKQASEGPLK 11 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 48780000.0 14186500.0 19612000.0 14981500.0 True False 13736157.32279749 27443173.875228923 11057395.714633852 1.0 1.9978785354825768 0.8049846441611602 23.71147513221693 -6.684750153964048 1.8850162603504892 1.6286341979484549 0.8093344200162657 0.34611204360727743 0.42248791485677195 0.42798607794193455 2.944163813639671 0.1795797805732034 0.47076580938914026 2.0665686938364382e-07 6.684750153964048 -0.8192997779321892 VVK(ub)QASEGPLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVKQASEGPLK 11 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 179144000.0 33517000.0 37632000.0 107995000.0 True False 50847739.420920834 30916275.579841968 86649740.91410995 1.0 0.608016716808491 1.7041021272709462 25.599680300659667 -6.809998135777311 1.4145224740321516 0.7863732518434488 1.7232807769950365 0.8598303273155209 0.16978024426481733 0.2068010477934536 0.8155288750465591 0.0943772606178386 0.2183160739047598 1.548823267270678e-07 6.809998135777311 0.9369075251515877 VVK(ub)QASEGPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVKQASEGPLK 11 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 35605700.0 10622800.0 13554100.0 11428800.0 True False 14550336.230375916 12955235.044585157 8729552.823524462 1.0 0.890373585837779 0.5999554020820679 23.7945491556469 -6.954208211889004 0.5105606367703439 1.0053203595264433 0.4722553933246793 0.999491479178906 0.0038061731120744343 0.08183868361517696 0.02930012947763761 0.00437973564334062 0.02396980596950328 1.1111988623850529e-07 6.954208211889004 -0.5330649662017639 VVK(ub)QASEGPLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVKQASEGPLK 11 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 52351600.0 14186500.0 26081900.0 12083200.0 True False 11796703.318510586 25941391.627848167 14609741.253595572 1.0 2.1990373859061707 1.238459666156981 23.491880407651205 -10.471690844675834 5.17236450759931 0.9986696405879592 1.718748526031553 0.4274250641383228 0.3921542119453307 0.006025737605499168 0.000615472620600266 0.3803080902202902 0.12656722766743958 3.375274942806512e-11 10.471690844675834 0.7200788854435938 VVK(ub)QASEGPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVKQASEGPLK 11 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 162444000.0 33517000.0 38507000.0 90420000.0 True False 43388417.21884338 36364051.59962657 73964487.78754726 1.0 0.8381050503919705 1.7047058300025943 25.370806622752117 -6.85841654641267 1.1936909613696047 0.9125039772750047 1.7454231886866647 0.9516879792327114 0.08269131513266387 0.14844300923261936 0.4028218868137294 0.05406322760176653 0.12598489635944926 1.3854263824766458e-07 6.85841654641267 0.83291921141166 VVK(ub)QCCGTDGVEANYIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVKQCCGTDGVEANYIK 17 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 9365200.0 2062300.0 2778300.0 4524600.0 True False 2703695.2713416093 2363788.4697285765 4056437.795027899 1.0 0.8742806538828739 1.5003309870106187 21.366501126529208 -6.8544665794771165 1.213314588442802 0.9325602968574002 1.5276041959566067 0.9465614571604384 0.06250919391921303 0.15260963406887046 0.430081668464085 0.040262432462336545 0.09347750392970097 1.398084498815459e-07 6.8544665794771165 0.5950438990992065 VVK(ub)QCCGTDGVEANYIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVKQCCGTDGVEANYIK 17 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 65036500.0 6048500.0 15059000.0 43929000.0 True False 9176016.704580937 12371603.793495972 35246413.8952353 1.0 1.3482542798030985 3.8411453498814203 23.12943658705042 -6.9322257842438315 0.7282941956305279 0.9650439116965627 4.383184881213781 0.9969577743691542 0.06978702808189306 0.09149883872475337 0.07213962255340127 0.06444236265186436 0.22286793893196016 1.1688915410028e-07 6.9322257842438315 3.4181409695172182 up VVK(ub)QCCGTDGVEANYIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVKQCCGTDGVEANYIK 17 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 10373900.0 2062300.0 2009800.0 6301800.0 True False 2824788.041561949 1921000.390480167 4813444.629644968 1.0 0.6800511621459434 1.704002055666946 21.4297111880521 -6.822735673361279 1.3599143209320521 0.8280055706440502 1.7277103763355988 0.8905727992723844 0.141487212672027 0.189952721573485 0.6894982008202327 0.08174041968328226 0.18828286031132652 1.504057108731704e-07 6.822735673361279 0.8997048056915485 VVK(ub)QCCGTDGVEANYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVKQCCGTDGVEANYIK 17 1 O75533 O75533 SF3B1 Splicing factor 3B subunit 1 1 42346100.0 6048500.0 8524600.0 27773000.0 True False 7829902.4837596975 8050198.516274358 22718598.975044753 1.0 1.028135220454097 2.9015174866055196 22.90056290914287 -6.91016775112916 0.8945930385201369 0.9423037021747102 3.144490271124226 0.9909846897922735 0.08448812883157675 0.10430714718563272 0.1381668219616669 0.06922899095741748 0.19132583074245246 1.2297936574247997e-07 6.91016775112916 2.2021865689495157 up VVLAYEPVWAIGTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVLAYEPVWAIGTGK 15 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 0 158840000.0 40664000.0 96498000.0 21678000.0 False True 53310897.79073614 82100874.546258 19434968.510059375 1.0 1.54003924054201 0.3645590173016482 25.667927142441403 -6.781792285786803 1.5288919829257803 1.3050756526243468 0.3547209369453432 0.7736643012626669 0.22855592522490017 0.24780826337631706 1.1442433964351009 0.1177285963389023 0.2773762829353843 1.6527520869156216e-07 6.781792285786803 -0.9503547156790035 down VVLAYEPVWAIGTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVLAYEPVWAIGTGK 15 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 0 154132000.0 61840000.0 30793000.0 61499000.0 False True 59876923.04950461 43088805.48337362 45390566.96954695 1.0 0.7196229079398246 0.7580644538467561 25.8354967504162 -10.702292731084135 10.203242241930829 1.000239508624611 0.7388436809415653 0.9840095296818687 0.015693695399292894 8.557976738090646e-05 2.4970126757969474e-06 0.015208809662421465 0.005065118410159442 1.984756664520954e-11 10.702292731084135 -0.2613958276830457 VVLAYEPVWAIGTGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVLAYEPVWAIGTGK 15 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 0 178776000.0 18201000.0 126860000.0 33715000.0 False True 27612247.67133635 104220841.83829603 27051215.47219052 1.0 3.7744425256074075 0.9796817627516712 24.718804994089957 -6.647794957915684 2.0156601268180543 2.8034161780421747 0.991252656938965 0.18537760829934113 1.1847962222465953 0.5140070654872966 4.000070504967023 0.4770358480541655 1.312790096699481 2.2501166955958927e-07 6.647794957915684 -1.8121635211032097 VVLAYEPVWAIGTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVLAYEPVWAIGTGK 15 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 0 199277000.0 40664000.0 66261000.0 92352000.0 False True 55698579.70328034 63333369.92417478 70540359.64914353 1.0 1.1370733376248874 1.266466039617687 25.731137203964295 -6.971822922008861 0.2101334567877389 0.9323706358643844 1.474781435757711 0.9999933228932798 0.0002810793450419567 0.07571549964215829 0.006871849508033523 0.0038706120489430656 0.013404084543240345 1.0670311007577659e-07 6.971822922008861 0.5424107998933265 VVLAYEPVWAIGTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVLAYEPVWAIGTGK 15 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 0 116461000.0 61840000.0 27700000.0 26921000.0 False True 51422699.97650547 27550774.60198051 32550056.631359793 1.0 0.5357706735462779 0.63299003448344 25.615902025850477 -10.031676669417894 5.910650956371596 1.0000007857327193 0.5843803540148398 0.9605807340964674 0.039689637902752074 4.109445071097854e-07 6.733393905304868e-08 0.038429399374574895 0.012809775551172463 9.296582562199366e-11 10.031676669417894 -0.41562043171787955 VVLAYEPVWAIGTGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVLAYEPVWAIGTGK 15 0 P60174;P60174-3;P60174-4;U3KPZ0;U3KQF3 P60174 TPI1 Triosephosphate isomerase 0 109792000.0 18201000.0 55121000.0 36470000.0 False True 23561553.29534769 52053467.89474682 29832834.213800535 1.0 2.2092545106109345 1.2661658524733652 24.489931316182407 -10.287439763574174 4.858640579002997 0.9997454273770129 1.7377101815428218 0.4492908304785874 0.3850143324428392 0.0010620655548833039 0.00015576062626257613 0.37291407923303693 0.12426284146652668 5.158937143085177e-11 10.287439763574174 0.7379647541658089 VVLAYEPVWAIGTGK(ub)TATPQQAQEVHEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVLAYEPVWAIGTGKTATPQQAQEVHEK 28 1 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 1 20842100.0 7351000.0 9000000.0 4491100.0 True False 9637232.187185254 7657235.081725228 4026404.053673207 1.0 0.7945471202724728 0.41779672580963295 23.20018743329211 -6.961706194557495 0.41068573148813486 1.018420798584067 0.1799259546357716 0.9998283269161297 0.0031588327419749566 0.07909723631213689 0.018920571958139256 0.004852292150517196 0.03144886768821124 1.092178958784019e-07 6.961706194557495 -0.8384948439482953 down VVLAYEPVWAIGTGK(ub)TATPQQAQEVHEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVLAYEPVWAIGTGKTATPQQAQEVHEK 28 1 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 1 80770000.0 24596000.0 21546000.0 34628000.0 True False 37313930.20846047 17700947.960333623 27783760.62200846 1.0 0.4743790820598188 0.74459485952806 25.153210988816372 -10.4065012559923 5.007172434055277 1.0004167589908588 0.6094869707938984 0.7357827285473096 0.11031512920791542 0.0005137684663033845 6.089665625021605e-05 0.10692365943786823 0.035604054854727625 3.9219201210027994e-11 10.4065012559923 -0.39092978819696045 VVLAYEPVWAIGTGK(ub)TATPQQAQEVHEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVLAYEPVWAIGTGKTATPQQAQEVHEK 28 1 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 1 38818800.0 11786000.0 18272000.0 8760800.0 True False 9800581.208329454 18173565.10929198 10592642.774637522 1.0 1.8543354442945053 1.0808178157469783 23.224435877889874 -10.240305997149795 4.595379171674042 0.9998490716775682 1.4675766300235775 0.32759376622002456 0.31578724950786896 0.0004884578292164495 8.07514974782018e-05 0.30585759030905657 0.10191989652268707 5.7503463409261383e-11 10.240305997149795 0.4677275583460093 VVLAYEPVWAIGTGK(ub)TATPQQAQEVHEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVLAYEPVWAIGTGKTATPQQAQEVHEK 28 1 P60174;P60174-3;P60174-4;U3KPZ0 P60174 TPI1 Triosephosphate isomerase 1 86842000.0 24596000.0 37123000.0 25123000.0 True False 31840006.85964353 35057072.41626033 20550871.783748582 1.0 1.1010384693319384 0.6454418139525069 24.92433731090882 -6.848527959843601 1.2421714766658492 1.0538573004050444 0.6277392188878689 0.938137072026422 0.04859036226273694 0.1590828580277413 0.4730957179197115 0.030620580317301256 0.070794544361465 1.4173334606919762e-07 6.848527959843601 -0.42611808151717556 VVLDDKDYFLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVLDDKDYFLFR 12 1 P61604;B8ZZ54 P61604 HSPE1 10 kDa heat shock protein, mitochondrial 0 118909500.0 14771100.0 50068400.0 54070000.0 False True 19365055.14353586 42598389.88509457 48475355.07606382 1.0 2.199755671716437 2.503238680022303 24.206952273772604 -10.333324930318234 0.3034639165271496 1.5781058509513478e-14 2.599560619718228 0.99901776203065 0.020341259871700667 1.8284390398568988 0.14349972827264135 1.5666144305549288 0.1069718089637966 4.641678642993307e-11 10.333324930318234 2.599560619718212 VVLDDKDYFLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVLDDKDYFLFR 12 1 P61604;B8ZZ54 P61604 HSPE1 10 kDa heat shock protein, mitochondrial 0 177045100.0 86261800.0 26746000.0 64037300.0 False True 83523466.37632208 37425817.2785474 47264010.052179195 1.0 0.4480874525719778 0.5658770175943989 26.315678251839575 -9.764837188395731 6.23103359671788 1.0000000099202273 0.5069822350828108 0.9589470476530566 0.048087388556913274 6.678821223365698e-09 1.224812353841663e-09 0.04656041514759598 0.01552013791999616 1.7185525303965145e-10 9.764837188395731 -0.4930177748374165 VVLDDKDYFLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVLDDKDYFLFR 12 1 P61604;B8ZZ54 P61604 HSPE1 10 kDa heat shock protein, mitochondrial 0 513773000.0 10710000.0 488063000.0 15000000.0 False True 16247853.005879445 400964344.3963761 12035243.425266454 1.0 24.67798940889502 0.7407282316569077 23.9537457569735 -12.955341073217065 1.6420836816516096e-10 8.464529204815832 14.612315840456791 0.0 11.551288084900387 0.0 0.7109311319590309 530990219.33386457 530990211.499291 1.1083040666705161e-13 12.955341073217065 6.1477866356409585 VVLDDKDYFLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVLDDKDYFLFR 12 1 P61604;B8ZZ54 P61604 HSPE1 10 kDa heat shock protein, mitochondrial 0 149682200.0 14771100.0 67584000.0 67327100.0 False True 20232374.84396822 64597915.40959872 51425825.625149965 1.0 3.192799456701297 2.5417592359643977 24.270162335295495 -9.989809399298203 5.284013018390672 0.9999914227314934 2.867279346339516 0.9164463614041207 0.26578605716238746 2.6856730972234902e-05 5.133123402637508e-06 0.2573474214569088 0.08578208108363931 1.0237421878749154e-10 9.989809399298203 1.8672879236080226 VVLDDKDYFLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVLDDKDYFLFR 12 1 P61604;B8ZZ54 P61604 HSPE1 10 kDa heat shock protein, mitochondrial 0 120232500.0 86261800.0 16769700.0 17201000.0 False True 71730508.74568759 16679358.297575165 20797649.571561977 1.0 0.2325280914528286 0.28994147588298436 26.09608352727385 -10.455779917196828 9.224072377224166 1.0000070563644972 0.26123478366790703 0.995490671199898 0.02343891604335566 3.4013060023779913e-06 2.0069366036926591e-07 0.022694849132450512 0.007564877624089191 3.501225499663049e-11 10.455779917196828 -0.7387722726965902 VVLDDKDYFLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVLDDKDYFLFR 12 1 P61604;B8ZZ54 P61604 HSPE1 10 kDa heat shock protein, mitochondrial 0 46612000.0 10710000.0 18124000.0 17778000.0 False True 13864306.125661958 17115383.46772356 14542586.417684298 1.0 1.2344926109243983 1.0489227723244574 23.72487207906595 -10.236151139836478 4.62854892989163 0.9999587065090889 1.1417076916251838 0.4374179905003345 0.075758569372665 3.229141401730759e-05 5.328933784982003e-06 0.07337427926203 0.024450973125704375 5.8056233950547616e-11 10.236151139836478 0.1417489851160949 VVLIGGK(ub)PDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVLIGGKPDR 10 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 47962000.0 15503000.0 19083000.0 13376000.0 True False 20324583.131265555 16235890.784951381 11991979.831652112 1.0 0.7988301988824318 0.5900234092971237 24.27672242632126 -6.970657060688232 0.24197928922077547 1.073160161335703 0.30963918347273633 0.999987062185296 0.0006020312614550975 0.07609009735789646 0.008263611729063848 0.00492211784696486 0.02028551450391384 1.0698993885325117e-07 6.970657060688232 -0.7635209778629666 VVLIGGK(ub)PDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVLIGGKPDR 10 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 196935000.0 41771000.0 53554000.0 101610000.0 True False 63369660.869149454 43996870.280688144 81526738.96275488 1.0 0.6942891862958879 1.2865263573225925 25.917288958996803 -6.766401241602986 1.5880845105970804 0.8238436388835847 1.2894230974844232 0.7166150714147026 0.12873135777795128 0.27231281047096856 1.3547752199355347 0.06391339681367539 0.15265716217784686 1.7123745257363468e-07 6.766401241602986 0.4655794586008385 VVLIGGK(ub)PDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVLIGGKPDR 10 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 48320000.0 15503000.0 13410000.0 19407000.0 True False 21234878.052822035 12817501.859060137 14823466.299711175 1.0 0.6036060968740407 0.6980716471664029 24.339932487844152 -9.787616750744682 6.058636581478546 1.0000000157629099 0.6508388720196348 0.9479589618211645 0.03856539941669084 8.243177869034214e-09 1.65310798705118e-09 0.03734078908850555 0.012446929139748035 1.6307344623579233e-10 9.787616750744682 -0.3491611437432751 VVLIGGK(ub)PDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVLIGGKPDR 10 1 P61978;P61978-2;P61978-3;Q5T6W2 P61978;P61978-3 HNRNPK Heterogeneous nuclear ribonucleoprotein K 1 156069000.0 41771000.0 43902000.0 70396000.0 True False 54073382.92950756 41458815.107040375 57584650.32395675 1.0 0.7667139147015808 1.0649352269863832 25.688415281089252 -6.6980053169286045 1.8377846410555134 0.8548576216907888 1.0640211975183775 0.4081874646952026 0.09850927467205903 0.39969690200106556 2.6230495193063623 0.04278359957064779 0.11030797924878218 2.004447487404686e-07 6.6980053169286045 0.2091635758275887 VVLLHGPPGTGK(ub)TSLCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVLLHGPPGTGKTSLCK 17 1 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 9154800.0 1986900.0 3959000.0 3208900.0 True False 2604845.1411669734 3368332.632061133 2876873.8099423153 1.0 1.2931028331888155 1.1044318007532197 21.31276617571996 -10.224531835745243 3.744600001739876 0.9997528637481159 1.1987673169608406 0.5967500966266542 0.07702462683369654 54705946.28677385 118745355.81718631 169079.3863131194 0.028188122568805415 5.963046064135234e-11 10.224531835745243 0.1990144532127247 VVLLHGPPGTGK(ub)TSLCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVLLHGPPGTGKTSLCK 17 1 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 65255500.0 5635500.0 17918000.0 41702000.0 True False 8549465.510236584 14720392.906027008 33459581.421364088 1.0 1.721791015871314 3.9136459912378996 23.027402798698812 -6.951176984413012 0.5457686455449333 0.9688988757537581 4.768763935525488 0.9992904453869893 0.033001974255877586 0.08301652877780363 0.03403274412259525 0.036017529169030664 0.18169253942856767 1.1189817812122846e-07 6.951176984413012 3.79986505977173 VVLLHGPPGTGK(ub)TSLCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVLLHGPPGTGKTSLCK 17 1 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 13110500.0 1986900.0 4051900.0 7071700.0 True False 2721510.6239535674 3872873.660158517 5401510.106233194 1.0 1.4230602761830677 1.9847470219999959 21.375976237242853 -6.967205741765729 0.3179272025866319 0.9211819146993739 2.5046872272376195 0.9999516607383624 0.0028043217406148956 0.0772202173817914 0.012261246888152824 0.00858674962834892 0.04949880388110362 1.0784357053044623e-07 6.967205741765729 1.5835053125382457 VVLLHGPPGTGK(ub)TSLCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVLLHGPPGTGKTSLCK 17 1 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 56642100.0 5635500.0 9289600.0 41717000.0 True False 7295265.842312617 8772625.593785308 34124934.05256703 1.0 1.2025093784662362 4.677682046162329 22.79852912079126 -6.91886748709861 0.8330902751507611 0.9201480492853936 5.2237296118267 0.9938603638987037 0.13226227963950285 0.09884264879372631 0.10910331053233896 0.1132793239608011 0.3357337463608079 1.205403679726678e-07 6.91886748709861 4.303581562541306 up VVLLTGETSTDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVLLTGETSTDLK 13 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 6510400.0 1838900.0 2732800.0 1938700.0 False True 2410815.70793293 2325076.8923709653 1738101.9213235606 1.0 0.9644357653387456 0.7209600947945688 21.201089939296832 -6.933111678805791 0.7207904341606216 1.0033091073047733 0.6667694912345284 0.9971152721664973 0.006660584823824265 0.0910540286388186 0.06999833038562787 0.006184594165807946 0.021665762095078797 1.1665096105972642e-07 6.933111678805791 -0.33653961607024485 VVLLTGETSTDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVLLTGETSTDLK 13 0 O75643 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 4814500.0 1838900.0 1542500.0 1433100.0 False True 2518791.024403949 1474347.2496346182 1094631.2956209655 1.0 0.5853392501998098 0.43458599185694696 21.264300000819723 -13.999999999999998 0.14074358526672276 2.982103184528915 0.24968174319191352 0.9995999855820213 0.00478135672712286 11.934841550519698 0.1175944074506334 6.494198363658563 0.16538613895047496 1.0000000000000041e-14 13.999999999999998 -2.7324214413370016 VVLPSYEEALSLPSK(ub)TPEGGPAPPPYSEV ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVLPSYEEALSLPSKTPEGGPAPPPYSEV 29 1 Q13571 Q13571 LAPTM5 Lysosomal-associated transmembrane protein 5 1 15248000.0 6402000.0 6090200.0 2755800.0 True False 6198772.014277619 8522048.619973429 2033973.3077721177 1.0 1.37479626615475 0.32812520013436064 22.56355101314957 -6.809847404776146 1.414943070916206 1.20429914841255 0.3098373133470312 0.8594876722327387 0.1623102889289883 0.20700650810800061 0.8168197946998963 0.09019438307504316 0.20867510979552423 1.5493609121383052e-07 6.809847404776146 -0.8944618350655189 down VVLPSYEEALSLPSK(ub)TPEGGPAPPPYSEV ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVLPSYEEALSLPSKTPEGGPAPPPYSEV 29 1 Q13571 Q13571 LAPTM5 Lysosomal-associated transmembrane protein 5 1 14167200.0 6402000.0 5687400.0 2077800.0 True False 5323546.656688028 5656760.847339483 2512258.3733382584 1.0 1.062592518135036 0.471914408824065 22.343956288583847 -6.880705037017128 1.0759027785942044 1.0391630309968845 0.4294906218298105 0.9742478337935943 0.04251464951631754 0.1270054048163517 0.2685514602762795 0.0304209313456982 0.07369643505256775 1.3161184065446242e-07 6.880705037017128 -0.609672409167074 down VVLSDAYAHPQQK(ub)VAVYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVLSDAYAHPQQKVAVYR 18 1 Q15628 Q15628 TRADD Tumor necrosis factor receptor type 1-associated DEATH domain protein 1 4482300.0 1316200.0 1541700.0 1624400.0 True False 1802834.7089675772 1473582.5962798647 1240750.1755681378 1.0 0.8173697726974293 0.688221815009693 20.781835700157583 -6.974854660857731 0.08124549022751616 1.4430033306141654 0.05934540942062256 0.9999998908652593 4.185802711126915e-05 0.07475641516611323 0.002358314303857096 0.015240021185647096 0.02475399099702821 1.0596082698409914e-07 6.974854660857731 -1.383657921193543 VVLSDAYAHPQQK(ub)VAVYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVLSDAYAHPQQKVAVYR 18 1 Q15628 Q15628 TRADD Tumor necrosis factor receptor type 1-associated DEATH domain protein 1 4259880.0 845280.0 1283300.0 2131300.0 True False 702887.7722532434 1276386.6081848943 2576944.9759822125 1.0 1.81591807194652 3.6662253601614303 19.42293483181591 -6.957515320285776 0.4691408308279024 0.950718040280472 4.607169389872866 0.9996666591254735 0.020365520493216854 0.08060091640302246 0.02450341973493039 0.025542410121249963 0.15272562450270408 1.1027693315839152e-07 6.957515320285776 3.6564513495923943 VVLSVSSGGQHTVLLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVLSVSSGGQHTVLLVK 17 0 P18754;P18754-2 P18754 RCC1 Regulator of chromosome condensation 0 107697000.0 65355000.0 17433000.0 24909000.0 False True 63280341.29851837 24394087.81189403 18384585.64601771 1.0 0.3854923553085386 0.290526019120067 25.91525404512768 -13.99999999999932 0.26287046577273565 5.566619582707311 0.2567590309552149 0.9995682453377982 0.006534164182616632 14.545869230069485 0.16225616454997488 35.346640550270116 0.04089943765952031 1.0000000000015665e-14 13.99999999999932 -5.309860551752096 VVLSVSSGGQHTVLLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVLSVSSGGQHTVLLVK 17 0 P18754;P18754-2 P18754 RCC1 Regulator of chromosome condensation 0 719942000.0 208131000.0 204570000.0 307241000.0 False True 315749943.4142579 168062885.18729472 246514681.68148586 1.0 0.5322657650227967 0.7807275561663786 28.23420723456548 -10.146705811182176 5.099128626437046 1.0000153064344635 0.6564966605941319 0.718189293915292 0.1014341014815436 141866821.9801341 2.395048561352711 25495.682968933714 0.03472359092582669 7.133360766407536e-11 10.146705811182176 -0.34351864584033154 VVLSVSSGGQHTVLLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVLSVSSGGQHTVLLVK 17 0 P18754;P18754-2 P18754 RCC1 Regulator of chromosome condensation 0 62389000.0 11015000.0 12456000.0 38918000.0 False True 15087543.16918239 11905652.73351624 29726369.941369604 1.0 0.7891047999010578 1.9702591474328492 23.846854563104095 -6.8607324641617025 1.1819141862826867 0.885334363617896 2.028292960898304 0.9545319574881876 0.10967611153467288 0.1460553798023667 0.3872583680902288 0.07234995218232838 0.16904101388766476 1.3780581243946601e-07 6.8607324641617025 1.142958597280408 VVLSVSSGGQHTVLLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVLSVSSGGQHTVLLVK 17 0 P18754;P18754-2 P18754 RCC1 Regulator of chromosome condensation 0 102953000.0 65355000.0 23420000.0 14178000.0 False True 54345578.217408106 23293831.811494 17142554.24833472 1.0 0.428624233572557 0.31543604485642546 25.695659320561955 -13.999999999999991 0.2276116788492817 4.5675152707344235 0.25913730014602104 0.9995066267853546 0.006654995425103664 13.218031327242835 0.15107816193673057 21.28266849376112 0.059640400872495586 1.0000000000000205e-14 13.999999999999991 -4.308377970588403 VVLSVSSGGQHTVLLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVLSVSSGGQHTVLLVK 17 0 P18754;P18754-2 P18754 RCC1 Regulator of chromosome condensation 0 676251000.0 208131000.0 276276000.0 191844000.0 False True 269429682.3753646 260900997.7338774 156930360.48566908 1.0 0.9683454155225363 0.5824538673769303 28.00533355665793 -6.923168367159575 0.8008850569129043 1.0075820494905414 0.5154543020419258 0.9950165222471338 0.013399575347953052 0.0963434479682352 0.09621828920378173 0.011743183641424978 0.036315997086109414 1.1935253092140176e-07 6.923168367159575 -0.49212774744861565 VVLTQANK(ub)LGV ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVLTQANKLGV 11 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;O94979-7;H7BXG7;H0Y8W8;H0YAF5 D6REX3 SEC31A Protein transport protein Sec31A 1 6117400.0 1001100.0 1732800.0 3383500.0 True False 969320.6284744361 2424716.076432625 2497259.8471757597 1.0 2.5014592748828224 2.576299083932701 19.886614428620106 -10.653456646616347 0.5642642886949846 7.84597743724558e-15 2.569270350963286 0.9998089140167717 0.010036850532536779 2.1545451997482696 0.2737333918912096 3.025585920882017 0.013661000033035574 2.2209733807306585e-11 10.653456646616347 2.569270350963278 VVLTQANK(ub)LGV ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVLTQANKLGV 11 1 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;O94979-7;H7BXG7;H0Y8W8;H0YAF5 D6REX3 SEC31A Protein transport protein Sec31A 1 3784970.0 1001100.0 1802800.0 981070.0 True False 832459.0062496716 1793087.9585722194 1186207.2010448403 1.0 2.1539654747088357 1.4249436814778988 19.667019704054383 -10.253735698208834 5.675939824459608 0.9999703354751821 1.7894545777264546 0.6099160653827267 0.2976219009446195 0.00017278119863461058 2.2717039249506514e-05 0.2881878089680239 0.09605705546325646 5.57524942768868e-11 10.253735698208834 0.7894842422512725 VVLVLAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVLVLAGR 8 0 P61353;K7EQQ9;K7ERY7 P61353 RPL27 60S ribosomal protein L27 0 108717000.0 33136000.0 37224000.0 38357000.0 False True 43441616.88948047 31670324.298015527 34388185.58632476 1.0 0.7290318953502074 0.791595434254013 25.37257446521347 -10.125757407387438 5.1302577662483735 1.0000078442820683 0.7603136648017614 0.95138464233792 0.02554145780406391 2.2916853450595897e-06 3.9053508464599435e-07 0.024731219232788697 0.008243470059241932 7.48587537356977e-11 10.125757407387438 -0.2396941794803069 VVLVLAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVLVLAGR 8 0 P61353;K7EQQ9;K7ERY7 P61353 RPL27 60S ribosomal protein L27 0 77531000.0 34058000.0 15274000.0 28199000.0 False True 32976847.432406675 21372987.85285774 20812835.948133368 1.0 0.6481210157115956 0.6311347981578247 24.974950148765316 VVLVLAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVLVLAGR 8 0 P61353;K7EQQ9;K7ERY7 P61353 RPL27 60S ribosomal protein L27 0 169902000.0 39983000.0 67732000.0 62187000.0 False True 60657134.14884013 55644695.40746854 49895712.1924696 1.0 0.9173643989003487 0.8225860468454672 25.85417400116263 -6.969335725842257 0.2736413135605095 1.0225451297191397 0.714542260082427 0.9999766993898089 0.000349844839161306 0.07651929329239646 0.00980177794772897 0.0018173375098678713 0.008771502313369242 1.0731594992627482e-07 6.969335725842257 -0.30800286963671264 VVLVLAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVLVLAGR 8 0 P61353;K7EQQ9;K7ERY7 P61353 RPL27 60S ribosomal protein L27 0 130286000.0 33136000.0 43849000.0 53301000.0 False True 45387274.66672974 41911606.1907478 40712401.56855288 1.0 0.923421961298555 0.8970003567629126 25.435784526736363 -13.999999999999998 0.1484571203749821 1.3694352666478111 0.8674093086786899 0.9995714542046742 0.0009042096516820448 11.952247474743919 0.12126437730876345 1.274369393120762 0.026632831762337647 1.0000000000000041e-14 13.999999999999998 -0.5020259579691212 VVLVLAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVLVLAGR 8 0 P61353;K7EQQ9;K7ERY7 P61353 RPL27 60S ribosomal protein L27 0 80191000.0 34058000.0 17370000.0 28763000.0 False True 28320736.025223546 17276424.362324953 34777210.314914025 1.0 0.6100273787707318 1.2279769241851657 24.755355424199593 -6.736145808104217 1.7007285790487938 0.7669341635214384 1.2280469626993678 0.5875034449305991 0.16387237887377148 0.32485903530299143 1.8434328127242976 0.07627219240698263 0.1879685080948953 1.8359218556001666e-07 6.736145808104217 0.46111279917792936 VVLVLAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVLVLAGR 8 0 P61353;K7EQQ9;K7ERY7 P61353 RPL27 60S ribosomal protein L27 0 179476000.0 39983000.0 85388000.0 54105000.0 False True 51758781.68275836 80636082.73791547 44258445.164181 1.0 1.5579208033170646 0.8550905513087872 25.62530032325508 -6.6951333395390416 1.8478220987612077 1.3480690920382898 0.8573311829885712 0.39476678796101483 0.23571893675662925 0.40569810157370173 2.689443048467307 0.10189501525278667 0.2636721214479476 2.017746768587939e-07 6.6951333395390416 -0.4907379090497186 VVLVNVSISWPNGISVDYQDGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVLVNVSISWPNGISVDYQDGK 22 0 Q07954 Q07954 LRP1 Prolow-density lipoprotein receptor-related protein 1;Low-density lipoprotein receptor-related protein 1 85 kDa subunit;Low-density lipoprotein receptor-related protein 1 515 kDa subunit;Low-density lipoprotein receptor-related protein 1 intracellular domain 0 10966500.0 3371300.0 3591800.0 4003400.0 False True 3264279.926856318 5026024.47098956 2954789.4405743866 1.0 1.5397038806748107 0.9051887420145405 21.638333349602632 -6.681360483357838 1.8968677267536869 1.341054126217764 0.9075663537383175 0.3304497743514794 0.22867073266676874 0.4355045353156978 3.030737905667734 0.09668634445418499 0.2545774945811032 2.0827613826476392e-07 6.681360483357838 -0.4334877724794465 VVLVTSGGTK(ub)VPLEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVLVTSGGTKVPLEAR 16 1 Q9HAB8;Q5VVM3 Q9HAB8 PPCS Phosphopantothenate--cysteine ligase 1 7845300.0 1752700.0 1421900.0 4670700.0 True False 1697061.497879476 1989672.085110545 3447303.552003492 1.0 1.1724219114019696 2.031336846844378 20.694607415335078 -6.939888909431407 0.6606043907089908 0.9903404162215346 2.2621975984921527 0.9981492136313341 0.019405072079950514 0.08781749421762608 0.05484244243125978 0.01887343361643908 0.07396141216877056 1.1484473515777026e-07 6.939888909431407 1.2718571822706182 up VVLVTSGGTK(ub)VPLEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVLVTSGGTKVPLEAR 16 1 Q9HAB8;Q5VVM3 Q9HAB8 PPCS Phosphopantothenate--cysteine ligase 1 6062800.0 1752700.0 2312700.0 1997400.0 True False 1457447.707775246 2300241.0260649906 2415047.105065857 1.0 1.578266591517198 1.6570385971187676 20.475012690769354 -11.51153802125907 0.3389358836597811 2.6581159077220015e-20 1.6713419771333218 0.9994841243142423 0.006653394651701873 3.935657425741845 0.17575700504376793 2.9010802625062606 0.024393259684705796 3.079370739463295e-12 11.51153802125907 1.6713419771333218 VVMALGDYMGASCHACIGGTNVR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VVMALGDYMGASCHACIGGTNVR 23 0 P60842;J3KT12;P60842-2;J3QS69;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25;J3QKZ9 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 0 38331600.0 6968400.0 9577500.0 21785700.0 False True 9544805.793929247 9154334.381442823 16640366.350575445 1.0 0.9590906906943277 1.7433949636941974 23.186284413052334 -6.894600078018739 0.9947955674141953 0.9623866877464952 1.8172538899761916 0.9836821531385406 0.04604682257168834 0.11548942624728853 0.2006913775762201 0.03503890782325861 0.08892842164786328 1.2746763320363377e-07 6.894600078018739 0.8548672022296965 VVNAVLTQIDQIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVNAVLTQIDQIK 13 0 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 11266700.0 4194300.0 5971300.0 1101100.0 False True 5498767.917658976 5080405.315945099 987168.7344970201 1.0 0.9239170286910401 0.1795254408404444 22.39067696646901 -6.9265562839903145 0.7745496530353112 1.0128825257053633 0.03930240241051639 0.9958167137356092 0.023940554266321374 0.09446636249649808 0.08673620541258997 0.02137950150895709 0.06867446459668032 1.1842508797041745e-07 6.9265562839903145 -0.9735801232948469 down VVNAVLTQIDQIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVNAVLTQIDQIK 13 0 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 8314700.0 4194300.0 2635800.0 1484600.0 False True 5745046.056695571 2519341.6405749954 1133968.0562967602 1.0 0.4385241851349173 0.19738189130358244 22.4538870279919 -10.074665601232724 0.20569182014210668 1.6444660735372085 1.6677645992416704e-15 0.9993777163220757 0.008388059618797449 1.6056107317967596 0.09565686097662154 0.7093151572624329 0.1378730663890535 8.420432499203057e-11 10.074665601232724 -1.6444660735372068 VVNAVLTQIDQIK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVNAVLTQIDQIKR 14 1 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 13416100.0 3772100.0 4756100.0 4887900.0 True False 4945259.629068357 4046508.4191325926 4382146.996047575 1.0 0.8182600556191463 0.8861308252228474 22.237614834643598 -10.799830132275902 9.716385899942264 1.0016778770974026 0.8521954409006886 0.8634509078882049 0.02770812566317769 0.0010171094477169193 2.0953697080294103e-05 0.027094824227555093 0.008942759104009127 1.5855132207339207e-11 10.799830132275902 -0.14948243619671409 VVNAVLTQIDQIK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVNAVLTQIDQIKR 14 1 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 24018700.0 3281100.0 8945600.0 11792000.0 True False 3176943.27648334 12517624.73068774 8703321.447582835 1.0 3.940147381083838 2.7395268628204215 21.59920790065139 -9.110072108278102 11.036534054679976 0.9999639749059602 3.3398365460816968 0.835093860893244 0.4901512745189329 0.0 0.0 0.47458693063420754 0.1581956435447358 7.761182427913995e-10 9.110072108278102 2.3398725711757367 VVNAVLTQIDQIK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVNAVLTQIDQIKR 14 1 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 69080300.0 5545300.0 15320000.0 48215000.0 True False 8412625.515733277 12586026.304293675 38685284.11661475 1.0 1.4960877886166823 4.598479279062833 23.00412469410806 -6.934964376719078 0.704848661240113 0.9603718745553927 5.324171322255775 0.9974271972942494 0.0807680695968411 0.09014068577445947 0.06564362505121606 0.07589296663007282 0.2734573582927687 1.1615438863084654e-07 6.934964376719078 4.363799447700382 up VVNAVLTQIDQIK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVNAVLTQIDQIKR 14 1 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 24752900.0 3772100.0 4113800.0 16867000.0 True False 5166747.307169575 3932038.713482589 12883361.986769134 1.0 0.7610278729959065 2.4935150145414875 22.30082489616649 -6.872038984321346 1.1233267797251665 0.8630433314244195 2.598955811000969 0.9666724947894036 0.13995080721362854 0.13491109085510677 0.31694484027613556 0.09656829852990707 0.22946145664927056 1.3426444336305117e-07 6.872038984321346 1.7359124795765497 up VVNAVLTQIDQIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVNAVLTQIDQIKR 14 1 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 18532400.0 3281100.0 4947300.0 10304000.0 True False 2728380.0273756837 4920647.9129378395 12458518.759686893 1.0 1.8035053268113856 4.566269593928316 21.379613176085666 -6.948351239630866 0.5766601827806904 0.9665456024855563 5.539098396734489 0.9990654667290951 0.04669305935773476 0.08415462944285303 0.03875494714012589 0.04910072656310455 0.2305829928630972 1.1262861934780722e-07 6.948351239630866 4.572552794248932 VVNAVLTQIDQIK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVNAVLTQIDQIKR 14 1 Q15645 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 63225300.0 5545300.0 14094000.0 43586000.0 True False 7178500.164204796 13309656.510378288 35653795.23012642 1.0 1.8540999102773825 4.966747149761471 22.77525101620051 -6.947015869123324 0.5906976154552459 0.9640964388163927 6.013562506161444 0.9989458089257599 0.055347798338700474 0.08470662149775035 0.04109548142836915 0.05733990288376666 0.2608169789751929 1.1297546326766147e-07 6.947015869123324 5.049466067345051 VVNISSLQCLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVNISSLQCLR 11 0 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 0 17287600.0 3525100.0 6920300.0 6842200.0 False True 4621440.237116958 5887818.215118121 6134234.779016897 1.0 1.2740223638142687 1.3273426603572573 22.139911096104846 -12.843586925943361 0.24723499014366795 7.3256851813550825e-06 1.3503506717794818 0.9994612994320333 0.0033284103659461254 7.909759873328647 0.1515457982734279 3.9317092772297744 0.024987877441866743 1.4335507558738832e-13 12.843586925943361 1.3503433460943004 VVNISSLQCLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVNISSLQCLR 11 0 O75828 O75828 CBR3 Carbonyl reductase [NADPH] 3 0 12218300.0 3525100.0 3683800.0 5009400.0 False True 4828424.732245562 3521037.5353024383 3826282.8918314623 1.0 0.7292311117097822 0.7924495262975692 22.203121157627738 -9.908355650018404 5.209617464438331 1.0000004916301344 0.7608403190004782 0.9502045500692424 0.025808809692463516 1.4737579040105429e-07 3.087830315010155e-08 0.024989323912390993 0.008329757508755156 1.2349357125686293e-10 9.908355650018404 -0.23916017262965616 VVNISSMLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVNISSMLGR 10 0 Q02338;E9PCG9;H7C2W1;C9K0G7 Q02338 BDH1 D-beta-hydroxybutyrate dehydrogenase, mitochondrial 0 5035400.0 1482100.0 1672700.0 1880600.0 False True 1943047.4526768182 1423139.6801335337 1686013.5519890084 1.0 0.7324266209623242 0.8677160970342181 20.889889703858117 -10.21984212711408 4.843464579778536 1.0000332818906243 0.8000713589978519 0.7443628530352344 0.05523169732554829 1.9853022183585706e-05 3.197829725378115e-06 0.0534867558625791 0.01782595366017897 6.027786657934964e-11 10.21984212711408 -0.19996192289277248 VVNISSMLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVNISSMLGR 10 0 Q02338;E9PCG9;H7C2W1;C9K0G7 Q02338 BDH1 D-beta-hydroxybutyrate dehydrogenase, mitochondrial 0 6065200.0 1482100.0 1518400.0 3064700.0 False True 2030072.4222465053 1451312.0673226612 2340880.979477756 1.0 0.7149065478740999 1.153102201589097 20.95309976538101 -6.731105923828192 1.7190719102336236 0.8286447053441879 1.1529005847729652 0.5644345163930585 0.11983650174108319 0.33417225836544656 1.9351747816951521 0.05522960834337863 0.13688384255677088 1.8573513943870914e-07 6.731105923828192 0.3242558794287773 VVNISSMLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVNISSMLGR 10 0 Q02338;E9PCG9;H7C2W1;C9K0G7 Q02338 BDH1 D-beta-hydroxybutyrate dehydrogenase, mitochondrial 0 3664140.0 1505300.0 1569100.0 589740.0 False True 1251723.6460969222 1560646.9468580356 713051.9073503257 1.0 1.246798326231502 0.5696560175832242 20.255484650433463 -6.808075375238646 1.422587189689396 1.13481103998055 0.5583212592688429 0.8547538849463168 0.10663767482787694 0.2094329273921993 0.8357049794988967 0.05894776229811416 0.13648239120490194 1.5556956049095115e-07 6.808075375238646 -0.5764897807117071 VVNLGVLAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVNLGVLAQK 10 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 5458100.0 1368000.0 2141000.0 1949100.0 False True 1793461.2477308463 1821571.1455526354 1747425.8290874064 1.0 1.0156735462544033 0.974331523080476 20.77431514187886 -6.803961461696034 1.4395363297922492 1.0086048580359233 0.9737024451509972 0.8435324558088864 0.006740903104740126 0.21515041117510247 0.879731337610789 0.0036830472482022036 0.008546166999207138 1.5705021609380118e-07 6.803961461696034 -0.034902412884926015 VVNLGVLAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVNLGVLAQK 10 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 2992400.0 924870.0 651430.0 1416100.0 False True 895510.5080982433 911549.3961625725 1045180.9279106236 1.0 1.0179103292694915 1.1671341859854094 19.77235083561765 -6.92934682966897 0.7521265378355116 0.997674985059577 1.1972664511667408 0.9964084770370119 0.004490137000988087 0.09297816853203598 0.07934983161546166 0.004074969203947753 0.01355097708588295 1.1766659071284652e-07 6.92934682966897 0.19959146610716383 VVNLGVLAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVNLGVLAQK 10 0 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 0 3253200.0 1368000.0 1885200.0 0.0 False True 1873786.568809945 1801905.6304772685 0.0 1.0 0.9616386735132121 0.0 20.83752520340175 -7.0550597695415025 1.0445009017525533 1.0110202944823312 9.604506325605785e-20 0.9881037149681487 0.05045885910529227 0.08496631544711464 0.1782468474490447 0.04040557181236845 0.07224952564777756 8.809276274801587e-08 7.0550597695415025 -1.0110202944823312 down VVNPLFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVNPLFEK 8 0 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 0 5981500.0 2314200.0 1170600.0 2496700.0 False True 2240736.9877290335 1638026.6845983567 1842739.370605503 1.0 0.7310213976779496 0.822380931227945 21.095541888066546 -10.726355198285003 9.74432368580058 1.0004812856749614 0.7767011644529473 0.8884592369566151 0.037297373389361545 0.0003907684231099123 1.0973743664446787e-05 0.03618664837123 0.012037675499523079 1.8777804003055658e-11 10.726355198285003 -0.22378012122201407 VVNPLFEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVNPLFEKR 9 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 6323500.0 1631900.0 1125000.0 3566600.0 True False 2139436.7033420797 957154.3852156535 3197562.4452430042 1.0 0.4473861665177816 1.4945814663495274 21.02879956582457 -6.76331608185701 1.5998530358511829 0.6803371299591967 1.49906480450278 0.7043984238824302 0.23255603118046758 0.2773868612608927 1.3999760025721577 0.11464825644293977 0.2746381984389126 1.7245822748788756e-07 6.76331608185701 0.8187276745435832 VVNPLFEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVNPLFEKR 9 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 7560100.0 1262100.0 2284600.0 4013400.0 True False 1222035.3263386125 3196852.6940316083 2962170.1405808157 1.0 2.6160067758514174 2.4239644114510903 20.220854560206575 -9.868900844748747 5.832560358381686 0.9999996157524371 2.519985593653454 0.9881693719676672 0.0784009669708752 3.917695346444219e-07 7.602461250467393e-08 0.07591142907553697 0.025303803282590406 1.3523812947252916e-10 9.868900844748747 1.519985977901017 VVNPLFEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVNPLFEKR 9 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 5457500.0 1631900.0 1446200.0 2379400.0 True False 2235257.530439288 1382302.1020561324 1817434.7252812292 1.0 0.6184084308998942 0.8130762118153136 21.092009627347462 -10.51064667893616 7.262802996945563 1.0000793654991214 0.7157423213576238 0.739785795418685 0.07947278876711382 0.00010215986419088657 6.883337168631523e-06 0.07697054512449228 0.02564973228097431 3.085697304007398e-11 10.51064667893616 -0.2843370441414975 VVNPLFEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVNPLFEKR 9 1 P62424;Q5T8U3 P62424 RPL7A 60S ribosomal protein L7a 1 6092500.0 1262100.0 3002100.0 1828300.0 True False 1049492.0705101485 2985927.0914298072 2210589.076895923 1.0 2.845116390425299 2.106341857181804 20.00125983564085 -10.45699741668119 5.873448427795847 0.9990456471444505 2.475729123803552 0.8417772330805711 0.3016034402348975 0.003770926188453087 0.00034862344280482726 0.2921660521728731 0.0973420917657181 3.491423922800752e-11 10.45699741668119 1.4766834766591015 VVNSILAFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVNSILAFR 9 0 Q03154;A0A1B0GV31;A0A1B0GU86;A0A1B0GW23;Q03154-4;C9JMV9;Q03154-2;A0A1B0GVA5 Q03154 ACY1;ABHD14A-ACY1 Aminoacylase-1 0 4696400.0 1827800.0 1420000.0 1448600.0 False True 2396263.500440379 1208141.5351166476 1298712.7679523942 1.0 0.5041772471577598 0.5419741058167101 21.192355129319225 -9.983710571669151 6.054366498404975 1.0000003353211442 0.5230756776509965 0.9953115118798408 0.015430502932610985 6.984192704127687e-08 1.1693509032219753e-08 0.01494053068364838 0.004980173406772722 1.0382200898180819e-10 9.983710571669151 -0.4769246576701477 VVNSILAFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVNSILAFR 9 0 Q03154;A0A1B0GV31;A0A1B0GU86;A0A1B0GW23;Q03154-4;C9JMV9;Q03154-2;A0A1B0GVA5 Q03154 ACY1;ABHD14A-ACY1 Aminoacylase-1 0 4386750.0 1908100.0 983450.0 1495200.0 False True 1847528.4099411347 1376146.7136239985 1103562.2649614888 1.0 0.7448582150181088 0.5973181570705319 20.817165118575737 -13.135335063507993 0.06661192941026962 2.387210882323528 2.3046124781983153e-14 0.9999481641775761 0.0011975788655555636 9.169876165819515 0.06073812435424767 2.2379062909039193 0.5060860324069538 7.322593680866706e-14 13.135335063507993 -2.387210882323505 VVNSILAFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVNSILAFR 9 0 Q03154;A0A1B0GV31;A0A1B0GU86;A0A1B0GW23;Q03154-4;C9JMV9;Q03154-2;A0A1B0GVA5 Q03154 ACY1;ABHD14A-ACY1 Aminoacylase-1 0 6649700.0 1827800.0 1371400.0 3450500.0 False True 2503587.05443773 1310807.0133866565 2635562.9652781724 1.0 0.5235715734602426 1.0527147280964362 21.255565190842116 -6.669424671920606 1.9389906428576638 0.6957597651122984 1.050592005327376 0.2767214706412997 0.20240089799063446 0.46241430821081525 3.351050357776348 0.08404379376940822 0.22474706962928034 2.1407962142029023e-07 6.669424671920606 0.35483224021507764 VVPGNRVTIMGIYSIKKFGLTTSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVPGNRVTIMGIYSIKKFGLTTSR 24 3 P33992;B1AHB1;B1AHB2 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 19661700.0 8249900.0 6670500.0 4741300.0 False True 7988011.440266949 9334065.436197963 3499411.294048888 1.0 1.1685092724261334 0.4380829096474031 22.92940496830593 -6.84599845799843 1.254310164575681 1.0897006037715444 0.4110711578909545 0.9342683311798483 0.08006291882764494 0.16191432260865193 0.4922327152146157 0.049995530828361945 0.11543066948321684 1.4256126553589952e-07 6.84599845799843 -0.6786294458805899 down VVPGNRVTIMGIYSIKKFGLTTSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVPGNRVTIMGIYSIKKFGLTTSR 24 3 P33992;B1AHB1;B1AHB2 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 0 34854500.0 8249900.0 10131800.0 16472800.0 False True 6860157.382538367 10077217.982395152 19917186.318378348 1.0 1.4689485124707768 2.9033133218014706 22.709810243740208 -6.951014736292343 0.5475950035725768 0.9798744428154627 3.459493813544907 0.9992784972978487 0.02174806645869367 0.08308091891222341 0.03429639241388267 0.02367844924617097 0.1189395985224113 1.1193998998299473e-07 6.951014736292343 2.4796193707294445 up VVPGYGHAVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVPGYGHAVLR 11 0 O75390;B4DJV2;A0A0C4DGI3;H0YIC4 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 0 11135300.0 3139300.0 2618500.0 5377500.0 False True 4115652.7010244485 2227830.006833054 4821087.884622399 1.0 0.5413066088590306 1.1714029911761885 21.972689815003694 -6.71151516104877 1.7900021470961154 0.7184398314375592 1.1699769922361152 0.4722120165182312 0.19324579088073324 0.3720348104438306 2.3246458618778454 0.08588607370799543 0.21777485368731983 1.9430538594019136e-07 6.71151516104877 0.451537160798556 VVPGYGHAVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVPGYGHAVLR 11 0 O75390;B4DJV2;A0A0C4DGI3;H0YIC4 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 0 9074490.0 2292700.0 678690.0 6103100.0 False True 2219919.4934605286 949694.4563215942 4504515.020924597 1.0 0.4278058096787825 2.0291344051863427 21.082075926759337 -6.810077093493567 1.4141229005108078 0.6881849450875508 2.0572208464514747 0.8600461173493684 0.2478634463745536 0.20669785063869642 0.8146360073423367 0.13781787734768092 0.31880275124460905 1.5485417061707435e-07 6.810077093493567 1.369035901363924 up VVPGYGHAVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVPGYGHAVLR 11 0 O75390;B4DJV2;A0A0C4DGI3;H0YIC4 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 0 19765300.0 2891900.0 15508000.0 1365400.0 False True 4387223.726209413 12740476.235442951 1095528.0915239216 1.0 2.903995107277284 0.2497087360690548 22.064876847703864 -6.7141545738349615 1.7802090647336564 2.1655192838233193 0.2550972199822425 0.4848906453029217 0.8018322229501539 0.36678721630260325 2.2683244321085376 0.3580829270538553 0.9052088295868352 1.9312808143519966e-07 6.7141545738349615 -1.9104220638410767 VVPGYGHAVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVPGYGHAVLR 11 0 O75390;B4DJV2;A0A0C4DGI3;H0YIC4 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 0 9130300.0 3139300.0 2268000.0 3723000.0 False True 4299984.046392587 2167792.260726946 2843704.077591838 1.0 0.5041396054819286 0.661328983296467 22.035899876526585 -10.346603273370368 5.033383439472246 1.0002145934337259 0.5827342943891222 0.9038040965474972 0.06417229477212676 0.00015461316517959486 2.0070568992539733e-05 0.06216612223760845 0.020711519078325656 4.501909150844596e-11 10.346603273370368 -0.4174802990446037 VVPGYGHAVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVPGYGHAVLR 11 0 O75390;B4DJV2;A0A0C4DGI3;H0YIC4 O75390 CS Citrate synthase, mitochondrial;Citrate synthase 0 5153100.0 2292700.0 1561700.0 1298700.0 False True 1906481.6338314035 1553286.8121268193 1570252.1654896508 1.0 0.8147399820501925 0.8236387582365314 20.862481202193614 -9.846731960588997 13.062941633772834 1.00000009041311 0.8191893701433606 0.9981866286161485 0.0036329101656684295 0.0 0.0 0.0035175501423059196 0.001172516714101973 1.4232068960052313e-10 9.846731960588997 -0.18081072026974954 VVPINTPTAAVDQTLFPGK(ub)VHSLSWALR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVPINTPTAAVDQTLFPGKVHSLSWALR 28 1 E9PDU5;A0A087X295;Q9NNW5 E9PDU5 WDR6 WD repeat-containing protein 6 1 32125600.0 13957000.0 7902600.0 10266000.0 True False 18067611.63360074 7462813.363056303 8397693.338055305 1.0 0.41304924604298787 0.46479266370979144 24.106902472456476 -10.408405966490736 9.235674418186896 1.0000019286532464 0.43892095617316973 0.9936618569369046 0.021124161805230232 8.388770155909533e-07 5.3757700583143056e-08 0.020453451783335602 0.006817793906187306 3.904757192192808e-11 10.408405966490736 -0.5610809724800767 VVPSDLYPLVLGFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVPSDLYPLVLGFLR 15 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2;S4R349;S4R402;S4R341 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 1308010000.0 771300000.0 131270000.0 405440000.0 False True 746815503.6882739 183686795.5640067 299243101.06071836 1.0 0.24596007267770764 0.40069213826287214 29.476176636933527 -10.179393001899243 7.846648472349004 1.0000002462435038 0.32332610551948504 0.9622638792445287 0.06316910125508574 2.7204961539965723e-07 2.8573383535686453e-08 0.06116324116141039 0.020387739762986433 6.616175215912375e-11 10.179393001899243 -0.6766741407240188 VVPSDLYPLVLGFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVPSDLYPLVLGFLR 15 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2;S4R349;S4R402;S4R341 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 3822760000.0 1658200000.0 968960000.0 1195600000.0 False True 2515610630.6582003 796041517.4809655 959289135.9499031 1.0 0.31644067161247613 0.38133450553073417 31.228261491350622 -10.103656754949705 5.151049490531483 1.0000157234396685 0.34888758858874264 0.9926050932548737 0.026492796762652173 4.783926178100583e-06 8.3240661090113e-07 0.025652158856628922 0.008550513387460164 7.876680779523606e-11 10.103656754949705 -0.6511281348509259 VVPSDLYPLVLGFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVPSDLYPLVLGFLR 15 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2;S4R349;S4R402;S4R341 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 1373690000.0 771300000.0 269580000.0 332810000.0 False True 641370124.3835485 268127719.03255942 402399032.26042265 1.0 0.4180545816509146 0.6274053264442082 29.256581912367803 -10.10808107912447 5.174268158715581 1.0000115807451884 0.5227299540468754 0.8738927473620024 0.08546708367160806 1.1418210245362945e-05 1.9682395012706356e-06 0.08275515446481947 0.02758438264207464 7.796845363943288e-11 10.10808107912447 -0.477281626698313 VVPSDLYPLVLGFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVPSDLYPLVLGFLR 15 0 A0A0A0MRM9;Q14978;Q14978-3;Q14978-2;S4R349;S4R402;S4R341 A0A0A0MRM9 NOLC1 Nucleolar and coiled-body phosphoprotein 1 0 3087760000.0 1658200000.0 772040000.0 657520000.0 False True 2146572588.008654 729075295.3222978 537858106.7249287 1.0 0.33964623390567517 0.25056599983133687 30.99938781344307 -13.999999999999998 0.2823016329760621 6.45067898540705 0.22435178585853421 0.9996102820895302 0.00659899790984468 15.524112227846766 0.1683469930345002 48.91975033094457 0.03485698769689543 1.0000000000000041e-14 13.999999999999998 -6.226327199548516 VVQDTYQIMK(ub)VEGHVFPEFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVQDTYQIMKVEGHVFPEFK 20 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 44416300.0 8761300.0 16080000.0 19575000.0 True False 11341675.56104223 15185133.864543987 16012550.85646136 1.0 1.3388792319808314 1.411832913953492 23.435130456611258 -12.458697894356975 0.24059310092379646 2.2473139011089586e-05 1.4460945920724089 0.9994176754579343 0.004329980196788807 6.525966370798248 0.14623330203923637 3.204303503755427 0.03548668460963722 3.477780000252478e-13 12.458697894356975 1.4460721189333978 VVQGLFDNFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVQGLFDNFLR 11 0 E7EXA6;Q8WVB6;Q8WVB6-2;A0A0D9SF58;Q8WVB6-3 E7EXA6 CHTF18 Chromosome transmission fidelity protein 18 homolog 0 2231400.0 929800.0 0.0 1301600.0 False True 1218976.8041960085 0.0 1166922.9178288253 1.0 0.0 0.9572970657128165 20.21723924262456 -11.860702846018215 17.0949630524798 0.85500742300865 0.5307836795707934 0.0 0.47742676171819565 0.0 0.0 0.0 0.13563235753219482 1.378152108814838e-12 11.860702846018215 -0.32422374343785654 VVQGLFDNFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVQGLFDNFLR 11 0 E7EXA6;Q8WVB6;Q8WVB6-2;A0A0D9SF58;Q8WVB6-3 E7EXA6 CHTF18 Chromosome transmission fidelity protein 18 homolog 0 4247000.0 929800.0 0.0 3317200.0 False True 1273572.1869002087 0.0 2533745.679878495 1.0 0.0 1.98947943896723 20.280449304147453 -6.770046790620535 1.5742767587199302 0.4264610801570729 2.0006888446235216 0.7307400401246542 0.4214555161125693 0.26635333709700804 1.3027672946636455 0.21101829282439383 0.5022890877572058 1.6980606945905386e-07 6.770046790620535 1.5742277644664486 VVQHSNVVINLIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVQHSNVVINLIGR 14 0 A0A3B3ISG8;Q16795 A0A3B3ISG8 NDUFA9 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial 0 7967900.0 1594900.0 2959700.0 3413300.0 False True 2184577.6305518867 2828930.667580928 2607148.8391201235 1.0 1.294955431209034 1.1934338256780022 21.058922943232766 -10.076129803705989 4.26146648284084 0.9999729249243844 1.2441946284125927 0.885245495386837 0.041446022050236765 6002003.294454874 7095792.904669351 1236.413422708535 0.014188076443953172 8.392091227864072e-11 10.076129803705989 0.24422170348820826 VVQMLGSLGGQINK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVQMLGSLGGQINK 14 0 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 0 5608500.0 1726800.0 1654200.0 2227500.0 False True 2365244.6250153566 1581111.9742921158 1701410.3768025278 1.0 0.6684771450571843 0.7193380163759938 21.17355797108994 -10.29484905090382 5.61036371959734 1.000033860960434 0.6939075807166272 0.9797127811209166 0.020763863767423205 8.795241149063618e-06 1.105444124035496e-06 0.020106744857659696 0.006701508214510056 5.07166955254036e-11 10.29484905090382 -0.30612628024380684 VVQVSAGDSHTAALTDDGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVQVSAGDSHTAALTDDGR 19 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 19222600.0 3938500.0 9698800.0 5585300.0 False True 5163411.640488254 8251776.845626292 5007386.733980745 1.0 1.5981249259541896 0.9697825938795855 22.299893187376558 -6.657325648557923 1.982258976652555 1.3858495632920171 0.9724071337572202 0.22433001220471938 0.25483159833373026 0.4908289381758 3.704609566461037 0.10396235198126699 0.2824385229751683 2.2012752541035866e-07 6.657325648557923 -0.41344242953479693 VVQVSAGDSHTAALTDDGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVQVSAGDSHTAALTDDGR 19 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 11392600.0 3193300.0 2334200.0 5865100.0 False True 3091930.4394240445 3266258.232692191 4328854.3607715545 1.0 1.0563815379043973 1.400049077940421 21.560076431980587 -6.935501443922581 0.7001583300623766 0.9956839993503771 1.4816244475978204 0.9975133902171597 0.008816313745687207 0.08987994180901011 0.06441116886908863 0.008313558633530126 0.03021096817154446 1.1601083590660267e-07 6.935501443922581 0.4859404482474433 VVQVSAGDSHTAALTDDGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVQVSAGDSHTAALTDDGR 19 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 29408400.0 2919700.0 22594000.0 3894700.0 False True 4429398.3586616535 18561924.172272272 3124910.837892349 1.0 4.190619734161994 0.7054932938649806 22.078679321395352 -6.665875675341799 1.95164295272573 3.043724349178161 0.7197097265265636 0.26098701021639414 1.3566060752433151 0.4707026411449463 3.4522684620541546 0.5603529964908127 1.5054126593363921 2.1583621909764228e-07 6.665875675341799 -2.3240146226515974 VVQVSAGDSHTAALTDDGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVQVSAGDSHTAALTDDGR 19 0 P18754;P18754-2;C9JW69;C9JRH2;C9J3R0;C9JMJ4;C9JQZ4 P18754 RCC1 Regulator of chromosome condensation 0 16397100.0 3938500.0 6285100.0 6173500.0 False True 5394669.883960497 6007403.499953675 4715446.447223523 1.0 1.1135812995369683 0.8740936051052076 22.36310324889945 -6.777745516827793 1.5447348862496855 1.064501075152236 0.872331565287188 0.7593038536344426 0.047988123792582014 0.25409350915051476 1.1974486365319477 0.02447231938934269 0.05785225265010773 1.668224454286411e-07 6.777745516827793 -0.19216950986504788 VVQVYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVQVYR 6 0 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10;H7C1F9;Q2PPJ7-3;Q2PPJ7-2;Q2PPJ7 P61254 RPL26;RPL26L1;RALGAPA2 60S ribosomal protein L26;60S ribosomal protein L26-like 1;Ral GTPase-activating protein subunit alpha-2 0 7012400.0 2404100.0 3055500.0 1552800.0 False True 3151798.38133752 2599631.3102457128 1392131.1515093732 1.0 0.8248088855044446 0.4416942275725766 21.58774381872892 -6.9582615609464336 0.459283457850027 1.0112473754643225 0.23983032533639412 0.9997001737156164 0.004036871091478973 0.08032814249656124 0.023471274744468622 0.005196822187659885 0.031651606234132594 1.1008760892349924e-07 6.9582615609464336 -0.7714170501279284 down VVQVYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVQVYR 6 0 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10;H7C1F9;Q2PPJ7-3;Q2PPJ7-2;Q2PPJ7 P61254 RPL26;RPL26L1;RALGAPA2 60S ribosomal protein L26;60S ribosomal protein L26-like 1;Ral GTPase-activating protein subunit alpha-2 0 7016900.0 2986400.0 2617000.0 1413500.0 False True 2891598.366672712 3661981.747474713 1043261.9459089522 1.0 1.2664212947693914 0.360790750863996 21.4634357500197 -6.8279299323686375 1.3371644074818465 1.142571949858711 0.3374394985267896 0.901670940595317 0.11916457539091474 0.18337477190199522 0.6419694942903332 0.06998685835032946 0.1610766478293343 1.4861753975555332e-07 6.8279299323686375 -0.8051324513319214 down VVQVYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVQVYR 6 0 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10;H7C1F9;Q2PPJ7-3;Q2PPJ7-2;Q2PPJ7 P61254 RPL26;RPL26L1;RALGAPA2 60S ribosomal protein L26;60S ribosomal protein L26-like 1;Ral GTPase-activating protein subunit alpha-2 0 7289000.0 2404100.0 2797700.0 2087200.0 False True 3292960.7383596404 2674088.3632432893 1594246.3472333273 1.0 0.8120620243335677 0.4841376724180098 21.650953880251812 -6.962623404426359 0.3967336114426856 1.0186888564100334 0.26560002786271675 0.9998554630545933 0.0025627856088035555 0.07877697114165957 0.01776378125008971 0.004222110530329081 0.02750891329768922 1.089874761348889e-07 6.962623404426359 -0.7530888285473166 down VVQVYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVQVYR 6 0 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10;H7C1F9;Q2PPJ7-3;Q2PPJ7-2;Q2PPJ7 P61254 RPL26;RPL26L1;RALGAPA2 60S ribosomal protein L26;60S ribosomal protein L26-like 1;Ral GTPase-activating protein subunit alpha-2 0 5768120.0 2986400.0 2240600.0 541120.0 False True 2483323.919952068 2228529.443075724 654265.6901438067 1.0 0.897397808304741 0.26346369270926007 21.243841025453975 -6.935217252725614 0.7026467847166782 1.008032704643789 0.11415445757780772 0.997467961217194 0.016390398877857724 0.09001781571612183 0.06506234458262224 0.015426655640352411 0.055806721732551794 1.160867752730107e-07 6.935217252725614 -0.8938782470659812 down VVSEDFLQDVSASTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVSEDFLQDVSASTK 15 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 30983800.0 4292800.0 12094000.0 14597000.0 False True 5627902.371534332 10289622.342042774 13086642.464311143 1.0 1.828322821320996 2.325314406749977 22.424165871366117 -8.907056253449701 0.156433350446755 7.708894763262466e-16 3.130692414068064 0.9998259948188973 0.007211103621838862 0.4055109729966559 0.04919709206182264 0.5429567573553152 0.3510262254555423 1.2386361376382589e-09 8.907056253449701 3.130692414068063 VVSEDFLQDVSASTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVSEDFLQDVSASTK 15 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 21757500.0 6671700.0 2378800.0 12707000.0 False True 6459910.535403936 3328667.2452781172 9378655.49817124 1.0 0.5152807035074483 1.4518243630110577 22.62308275420888 -6.766045859484341 1.5896742120115734 0.720576161446687 1.4563133010068294 0.7151827664387045 0.20409145076976412 0.272868694112555 1.3602368746842934 0.10123651567083013 0.24186137098644467 1.7137763311162206e-07 6.766045859484341 0.7357371395601424 VVSEDFLQDVSASTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVSEDFLQDVSASTK 15 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 29267800.0 4292800.0 11518000.0 13457000.0 False True 5879964.168557982 11009096.67506745 10278733.755614638 1.0 1.872306762333103 1.7480946245520101 22.48737593288901 -10.322063673639564 5.497597491291106 0.999848095176853 1.8102006934425727 0.9826773211522265 0.050709392904049674 9.443097567198578e-05 1.1644722481239019e-05 0.049108179992425574 0.0163663861844645 4.763611404857967e-11 10.322063673639564 0.8103525982657197 VVSETNDTK(ub)VLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVSETNDTKVLR 12 1 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 27968500.0 2469200.0 3574200.0 21925100.0 True False 2390816.597571748 5001396.69920677 16182258.57109894 1.0 2.09191985043373 6.768506872310733 21.18907203273962 -6.9433075703326645 0.6280382676988512 0.9489812473624937 8.162642243771376 0.9985658347476046 0.094750323132564 0.08628956125650304 0.047977652454592436 0.09473296341303898 0.3970144575401892 1.1394425407186542e-07 6.9433075703326645 7.2136609964088825 VVSETNDTK(ub)VLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVSETNDTKVLR 12 1 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 74059700.0 4152400.0 5548700.0 64358600.0 True False 6299494.381103063 4558491.132809029 51638094.5006236 1.0 0.7236280972776773 8.197180817483575 22.586804606960754 -6.898310527761958 0.9718662430609124 0.6747098342327102 8.955342723114896 0.985707480102427 0.4136195343349308 0.11266029979091335 0.18450734597851612 0.32017819195026515 0.826225592180641 1.2638323632139798e-07 6.898310527761958 8.280632888882186 up VVSETNDTK(ub)VLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVSETNDTKVLR 12 1 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 17637650.0 2469200.0 6747400.0 8421050.0 True False 2053249.2041071705 6711050.41694596 10181852.62046402 1.0 3.2685026267253203 4.958897634099642 20.969477308173897 -7.904269828742942 0.24047488871839642 7.095888218473221e-20 6.643376768946042 0.9996917203554514 0.02847797382027363 0.11724395702787452 0.041317371991178874 0.350699359004491 0.5417382540567159 1.2466087510301466e-08 7.904269828742942 6.643376768946042 VVSETNDTK(ub)VLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVSETNDTKVLR 12 1 P05783 P05783 KRT18 Keratin, type I cytoskeletal 18 1 51297700.0 4152400.0 9535300.0 37610000.0 True False 5375363.656040963 9004652.172797643 30765365.911188327 1.0 1.67517078824574 5.723401778894247 22.357930929053204 -6.935849176626413 0.6971064670372762 0.9496984924597298 6.693532926862377 0.9975681527305389 0.10285799013121645 0.08971223787174776 0.06362088821002049 0.097217184872929 0.3552579911477761 1.1591798504726773e-07 6.935849176626413 5.743834434402648 VVSIGVPVSELLDDPSGPAGSLTSVEFCGGTHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVSIGVPVSELLDDPSGPAGSLTSVEFCGGTHLR 34 0 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 156201000.0 43692000.0 70619000.0 41890000.0 False True 66283958.31306115 58016487.70123456 33610423.1389608 1.0 0.8752719236715002 0.5070672300561435 25.982156423501554 -6.951812464969469 0.5385807172331232 1.0054721108057076 0.359904702662946 0.9993359354070773 0.005392558541377721 0.0827660502201779 0.03301306349300142 0.005942830332878327 0.030485739944088673 1.1173456306350247e-07 6.951812464969469 -0.6455674081427616 VVSIGVPVSELLDDPSGPAGSLTSVEFCGGTHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVSIGVPVSELLDDPSGPAGSLTSVEFCGGTHLR 34 0 P49588;P49588-2;H3BPK7 P49588 AARS Alanine--tRNA ligase, cytoplasmic 0 79674000.0 43692000.0 11541000.0 24441000.0 False True 56560155.298078656 10898733.20464564 19992988.785837647 1.0 0.1926927736886159 0.35348185804073995 25.753282745594003 -10.13241428706049 7.5872264431930825 1.0000001900697344 0.27308731621966037 0.9646036250900681 0.06564186881200454 2.110560979124193e-07 2.4216177519953226e-08 0.06355748228035836 0.02118582206023547 7.372006558882748e-11 10.13241428706049 -0.7269128738500741 VVSK(ub)YIESPVLFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVSKYIESPVLFLR 14 1 Q14166 Q14166 TTLL12 Tubulin--tyrosine ligase-like protein 12 1 3078560.0 638360.0 1351100.0 1089100.0 True False 836896.1418870346 1149521.146546552 976410.379384892 1.0 1.3735529285086796 1.1667043621246485 19.6746890710698 -10.163630009836545 4.2957871825280005 0.9999339522789815 1.2701286452904204 0.6945556655515008 0.08444557368409573 59151739.932165496 5.354388377242402 40357.55486545888 0.02890796598168921 6.860724658975585e-11 10.163630009836545 0.27019469301143884 VVSK(ub)YIESPVLFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVSKYIESPVLFLR 14 1 Q14166 Q14166 TTLL12 Tubulin--tyrosine ligase-like protein 12 1 6214950.0 1382600.0 884350.0 3948000.0 True False 1338710.1197969757 1237475.566824326 2913900.36253876 1.0 0.9243790336118453 2.176647744308284 20.352412167023807 -6.892541336708753 1.0072079687709308 0.9367560328715767 2.28988234877942 0.9824763401835686 0.0758960647098152 0.11710619851486324 0.20998758047565114 0.057214015474507336 0.14400716373904385 1.2807331868986424e-07 6.892541336708753 1.3531263159078433 up VVSK(ub)YIESPVLFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVSKYIESPVLFLR 14 1 Q14166 Q14166 TTLL12 Tubulin--tyrosine ligase-like protein 12 1 5896300.0 1382600.0 1301700.0 3212000.0 True False 1149693.1595652716 1294687.4837327788 3883614.3493899764 1.0 1.1261156709172153 3.377957255010955 20.132817442458084 -6.918438449500856 0.8362251239434392 0.9474631621366699 3.728358719747453 0.9937360641801465 0.08646341038538231 0.09909940105872064 0.11043909940796055 0.07388749360818571 0.2181300050356657 1.2065950810834564e-07 6.918438449500856 2.780895557610783 up VVSQYHELVVQAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVSQYHELVVQAR 13 0 B9A067;Q16891-2;Q16891-4;Q16891;Q16891-3;C9J406;H7C463 B9A067 IMMT MICOS complex subunit MIC60 0 31210600.0 5882600.0 14165000.0 11163000.0 False True 7615141.663381805 13376705.29796426 9131448.542052533 1.0 1.7565930995463326 1.1991173566687598 22.8604394445341 -10.22807265168513 5.502074673567238 0.9999729553432587 1.4778552281075725 0.49486511083326346 0.22758851900494853 7.550870400827932e-05 1.05938206910371e-05 0.22037408161797847 0.07345387865783236 5.914626820663572e-11 10.22807265168513 0.47788227276431383 VVSQYSSLLSPMSVNAVMK ddPTM_RPMI8226_Bortezomib_1h_R1 2 VVSQYSSLLSPMSVNAVMK 19 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 52452350.0 15590900.0 23707500.0 13153950.0 False True 20439820.88249038 20170433.411111187 11792905.435598094 1.0 0.9868204583138024 0.5769573766519841 24.28487921796872 -6.913745883345286 0.869827741800043 1.0112367418821955 0.5195138240402033 0.992260226854015 0.017277731721589848 0.10199306041727055 0.12571331000813818 0.01441289147675148 0.04089907912115724 1.2197030691977346e-07 6.913745883345286 -0.4917229178419922 VVSQYSSLLSPMSVNAVMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 VVSQYSSLLSPMSVNAVMK 19 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 69738500.0 29297000.0 16678700.0 23762800.0 False True 28366982.77136702 23338591.888271485 17538609.811280653 1.0 0.822737901890254 0.6182754772560345 24.757709372022394 -6.969255206445492 0.27539265147957803 1.0476173479568236 0.3872045206326074 0.9999759759983359 0.0007644550156464428 0.07654511465355539 0.009891886089236177 0.003879769350060266 0.018878758968596806 1.0733584844443458e-07 6.969255206445492 -0.6604128273242162 VVSQYSSLLSPMSVNAVMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 VVSQYSSLLSPMSVNAVMK 19 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 127951700.0 29391000.0 66330500.0 32230200.0 False True 44588295.769916266 54493304.03243806 25859886.843001526 1.0 1.222143683482173 0.5799702903300735 25.410161722995962 -6.813286572875907 1.4006380813957604 1.1206038826337419 0.5678666797786566 0.8682493597182328 0.09665397305159054 0.20234881705927402 0.7817303012623872 0.05425067658180599 0.12531874352918776 1.5371400107864616e-07 6.813286572875907 -0.5527372028550853 VVSQYSSLLSPMSVNAVMK ddPTM_RPMI8226_Carfilzomib_1h_R1 3 VVSQYSSLLSPMSVNAVMK 19 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 84579830.0 18283430.0 26011300.0 40285100.0 False True 25043308.162117522 24862034.75813352 30770589.07767791 1.0 0.9927616031072839 1.228695062109403 24.577921815692864 -6.89982127596777 0.96238794296767 0.9901425885908788 1.2533713506074668 0.9864774457258936 0.012739634960402101 0.11153727065761249 0.17815878738836663 0.009931472813125612 0.025817167126357576 1.259443600577283e-07 6.89982127596777 0.26322876201658807 VVSQYSSLLSPMSVNAVMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 VVSQYSSLLSPMSVNAVMK 19 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 65185400.0 29297000.0 14594400.0 21294000.0 False True 24361753.577161722 14515777.070438428 25746476.94766818 1.0 0.5958428659276175 1.0568400532466016 24.53811464745667 -6.6750400081470795 1.918915976970964 0.743171975666535 1.055051992921361 0.30191251515310724 0.17147708351267038 0.4495889270463093 3.1960750121397323 0.07181005387769052 0.19064759096793815 2.113294349622465e-07 6.6750400081470795 0.31188001725482606 VVSQYSSLLSPMSVNAVMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 VVSQYSSLLSPMSVNAVMK 19 0 P50991;P50991-2 P50991 CCT4 T-complex protein 1 subunit delta 0 99615800.0 29391000.0 41581600.0 28643200.0 False True 38047228.88322418 39267547.406835966 23430431.504050788 1.0 1.0320737819660197 0.6158249152905261 25.18128804508841 -6.888299823308736 1.0324221921486334 1.0232857430963314 0.581198335020732 0.9797863113648573 0.026887479838605628 0.12053203283986283 0.23000956116531204 0.019886919852944534 0.049282892696799814 1.2933026775153525e-07 6.888299823308736 -0.4420874080755993 VVSSIEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVSSIEQK 8 0 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4 P63104 YWHAZ 14-3-3 protein zeta/delta 0 9294100.0 3137300.0 1367600.0 4789200.0 False True 3037708.1287711943 1913689.8119397853 3534764.84707969 1.0 0.6299781713109831 1.1636288600608788 21.5345518277741 -6.72016950703673 1.758692569060392 0.7749388344506051 1.1628112457342121 0.513493834174686 0.15570098794682233 0.3549010048085137 2.145371967482804 0.07029399739787869 0.176429899420942 1.9047171534245445e-07 6.72016950703673 0.38787241128360705 VVSSIEQK(ub)TEGAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVSSIEQKTEGAEK 14 1 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4 P63104 YWHAZ 14-3-3 protein zeta/delta 1 23745300.0 9259400.0 6381100.0 8104800.0 True False 8965465.415339312 8929106.506996907 5981909.741211785 1.0 0.9959445598574062 0.6672168665083619 23.09594704756266 -6.909592375360853 0.8985077117129914 1.0103097366100733 0.6251028719101543 0.9907667969618723 0.014983088590085302 0.10468814624843212 0.14023449758441056 0.012242186415832315 0.03369922735694978 1.2314240313652168e-07 6.909592375360853 -0.38520686469991894 VVSSIEQK(ub)TEGAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVSSIEQKTEGAEK 14 1 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4 P63104 YWHAZ 14-3-3 protein zeta/delta 1 28936200.0 9259400.0 15892000.0 3784800.0 True False 7699601.360971133 15806386.641684992 4576184.18106201 1.0 2.0528837663994812 0.5943404036809545 22.876352322996937 -6.713004146106863 1.7842671609909606 1.6452812301079498 0.5974181614983661 0.4794728461493639 0.4434759623817265 0.3690633787924651 2.2921243608755426 0.1976463825886928 0.5003370680215413 1.9364034774716326e-07 6.713004146106863 -1.0478630686095838 VVSSSIVDK(ub)YIGESAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVSSSIVDKYIGESAR 16 1 A0A087X2I1;P62333;H0YJC0;H0YJS8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 10782800.0 2303100.0 3145300.0 5334400.0 True False 2229989.3511532038 4401234.69252282 3937160.611430284 1.0 1.9736572689222893 1.765551306060831 21.08860539019839 -10.40200751463648 6.512788406169459 0.9998891532034364 1.8696042874915602 0.9588165713105196 0.08495890357352662 0.00013675865930288432 1.2556917076530946e-05 0.08227136219852359 0.027420368221025847 3.962711774802938e-11 10.40200751463648 0.8697151342881237 VVSSSIVDK(ub)YIGESAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVSSSIVDKYIGESAR 16 1 A0A087X2I1;P62333;H0YJC0;H0YJS8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 37839300.0 7784500.0 9868800.0 20186000.0 True False 11809655.623181023 8107635.534713671 16196228.252161883 1.0 0.6865259913929493 1.3714395041605203 23.493463559685573 -6.782237287115693 1.526878141069902 0.8230189176974376 1.3772775198996174 0.7753133366534827 0.1326986734015259 0.24711473504021006 1.1380147120877144 0.06843719895827774 0.1612024115373271 1.651059456155045e-07 6.782237287115693 0.5542586022021798 VVSSSIVDK(ub)YIGESAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVSSSIVDKYIGESAR 16 1 A0A087X2I1;P62333;H0YJC0;H0YJS8 A0A087X2I1 PSMC6 26S protease regulatory subunit 10B 1 8120200.0 2303100.0 3348500.0 2468600.0 True False 1915129.6946295248 3330460.965874789 2984772.8464832213 1.0 1.7390263308089193 1.5585225663062026 20.869010665632665 -10.119509571623391 4.576560367332518 0.9999502569800605 1.6487744485083695 0.9451296523242291 0.07369035359994074 38850165.0088996 2.974760373116486 24809.40784587864 0.026967907991201877 7.594346849398975e-11 10.119509571623391 0.6488241915283091 VVSTSGEQMK(ub)VYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVSTSGEQMKVYK 13 1 Q13422-4;Q13422-3;Q13422-7;Q13422;Q13422-2;A0A0A0MRA0;A0A0A0MST1;A0A087WU46;Q13422-6;Q13422-5;R9R4D9 Q13422-4 IKZF1 DNA-binding protein Ikaros 1 8146500.0 3482600.0 2643100.0 2020800.0 True False 2895936.205339228 2628861.095685724 2443339.9368764865 1.0 0.9077759001869247 0.8437133153595403 21.465598390925383 -6.975019829898746 0.06757240776726497 1.2872900939146636 0.46260040638006156 0.9999999417775377 1.4361440827219617e-05 0.07470563703645881 0.0019482474322503182 0.009494550974752849 0.01421329288384105 1.0592053607253861e-07 6.975019829898746 -0.8246896875346021 VVTDLISLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVTDLISLIR 10 0 P38432 P38432 COIL Coilin 0 3866000.0 1016900.0 1444300.0 1404800.0 False True 1333165.747673608 1228816.0698373062 1259444.7717931268 1.0 0.9217279036620966 0.9447023177657203 20.34642472595621 -10.731531445185313 6.688292171855743 1.0010692569377158 0.9332151107139084 0.9184800983180406 0.009379265282213271 0.0001518987607783994 6.097208837948196e-06 0.009224454551303048 0.003027144853139443 1.8555324543434295e-11 10.731531445185313 -0.06785414622380737 VVTDLISLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVTDLISLIR 10 0 P38432 P38432 COIL Coilin 0 4542900.0 1366700.0 1262100.0 1914100.0 False True 1323314.8565937579 1766063.1117645532 1412739.788230862 1.0 1.3345751413313982 1.0675764586118877 20.335724932530457 -10.405371034014749 5.00905988570029 0.9997887349266567 1.2010757999716641 0.4305907106445934 0.10900175577641698 0.000257438012767426 3.0560579565920496e-05 0.10565075435105184 0.03518016540244208 3.9321399449465284e-11 10.405371034014749 0.20128706504500748 VVTDLISLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVTDLISLIR 10 0 P38432 P38432 COIL Coilin 0 6933700.0 1016900.0 2034900.0 3881900.0 False True 1392875.4106892038 1944991.3894855657 2965075.1702400576 1.0 1.396385760391284 2.1287439978374803 20.409634787479103 -6.961564935906751 0.4127867039826487 0.9650015108572817 2.5874305501350925 0.9998239080525789 0.006204536561379893 0.07914676075318951 0.019100192990329806 0.00943899990719862 0.061092430008559934 1.0925342587607756e-07 6.961564935906751 1.6224290392778107 up VVTPLSPPTNLHLEANPDTGVLTVSWER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVTPLSPPTNLHLEANPDTGVLTVSWER 28 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 85656000.0 48181000.0 23948000.0 13527000.0 False True 73094099.50292057 19674292.293421973 10853382.520905275 1.0 0.2691638918492437 0.14848507054213883 26.123251614008193 -13.999999999999998 0.25343811650966475 6.172011963934692 0.10152459366541466 0.9995492571257574 0.007987066329425693 14.136950478723303 0.15929880210088884 37.29944446483811 0.05464799930366992 1.0000000000000041e-14 13.999999999999998 -6.070487370269277 VVTTPAFMCETALHYIHDGIGAMVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVTTPAFMCETALHYIHDGIGAMVR 25 0 A0A096LPI6;P0DPI2;A0A0B4J2D5;A0A096LNH5;P0DPI2-2;A0A0B4J2D5-2 A0A096LPI6 0 25086500.0 4469300.0 11443000.0 9174200.0 False True 6780254.849596368 9400907.245432919 7360915.348805291 1.0 1.3865123736451528 1.0856399224054962 22.692908070316907 -10.168395282030069 5.043278133487854 0.9999848980655305 1.236076148025645 0.450814097289453 0.12283066386737912 2.085883615025325e-05 3.439223336203085e-06 0.11893788192517536 0.03964342629666995 6.785857227448439e-11 10.168395282030069 0.23609124996011455 VVTTPAFMCETALHYIHDGIGAMVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVTTPAFMCETALHYIHDGIGAMVR 25 0 A0A096LPI6;P0DPI2;A0A0B4J2D5;A0A096LNH5;P0DPI2-2;A0A0B4J2D5-2 A0A096LPI6 0 14722600.0 4469300.0 5419400.0 4833900.0 False True 5785596.953073863 5117805.625964533 3954179.800002484 1.0 0.8845769360490043 0.6834523441702322 22.464034392409356 -6.962647930420926 0.3963529665284375 1.011510763825553 0.5492177708784091 0.9998561504761755 0.0015687601203173303 0.07876842359576648 0.017733075155171845 0.0025898007833663706 0.01687444309967623 1.0898132143828746e-07 6.962647930420926 -0.4622929929471439 VVTVHLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVTVHLEK 8 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 35738000.0 12999000.0 11139000.0 11600000.0 False True 17041814.88249507 9477104.619481921 10399743.275057158 1.0 0.5561088818783361 0.6102485766195896 24.022575648985985 -10.092240282395657 4.941089770316504 1.0000136341355186 0.5831787292475084 0.9875051081035823 0.022102437832167407 30746773.18345274 0.4370690369373529 4769.437256336962 0.00756625235914976 8.086483739670405e-11 10.092240282395657 -0.4168349048880102 VVTVHLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVTVHLEK 8 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 20410000.0 6105900.0 3467100.0 10837000.0 False True 5912071.546700678 4851531.110687641 7998464.596968734 1.0 0.8206144111018265 1.352903890588469 22.495232298119078 -6.815792824110026 1.3898900782883856 0.902881416360813 1.3635167565125075 0.874453126601988 0.07834908149640679 0.19900424029920846 0.7564838786802746 0.04430901766231927 0.10226163485398969 1.5282949423671754e-07 6.815792824110026 0.4606353401516945 VVTVHLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVTVHLEK 8 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 42749200.0 9259800.0 24274000.0 9215400.0 False True 14047793.582058148 19942115.046372365 7393972.150746696 1.0 1.4195905520595382 0.5263440203300169 23.743840215426875 -6.778977077069725 1.5399369955620474 1.2378975669078864 0.5195035919760196 0.7637312896539538 0.17736332836203694 0.2521646536330284 1.1810803012798086 0.0907230152017105 0.21424477558096294 1.6635004509297114e-07 6.778977077069725 -0.7183939749318669 VVTVHLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVTVHLEK 8 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 31446300.0 12999000.0 7864300.0 10583000.0 False True 17805081.584766418 7516829.222237622 8083513.363726665 1.0 0.42217325354290053 0.45400035519313303 24.085785710508876 -9.967838396261762 5.338573332753226 1.0000015353374208 0.43808680438412323 0.9975996566904493 0.012993359846804232 35704605.01107609 0.003142239929096297 761.6731907883988 0.004447972677493212 1.0768658477153037e-10 9.967838396261762 -0.5619147309532975 VVTVHLEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVTVHLEK 8 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 16733400.0 6105900.0 7213800.0 3413700.0 False True 5077326.387233903 7174937.827572813 4127488.8868345455 1.0 1.413133070509906 0.812925656544837 22.275637573553354 -6.721563392346292 1.754488971231029 1.2509373614806882 0.8138293816905181 0.5195362998119888 0.1738154408834646 0.35228282244874065 2.1202792004241493 0.07865034944625701 0.19702010363047565 1.898613688313045e-07 6.721563392346292 -0.43710797979017013 VVTVHLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVTVHLEK 8 0 Q9Y266 Q9Y266 NUDC Nuclear migration protein nudC 0 26741800.0 9259800.0 11248000.0 6234000.0 False True 11986993.637946296 10622038.912213359 5099475.966241643 1.0 0.8861303537016983 0.42541742494119855 23.514966537519324 -6.944612522890591 0.6151607369166188 1.0050635416544185 0.2822784663624994 0.9987077263451599 0.008929893130092554 0.08572403952955916 0.04549128062095252 0.009033222891978863 0.03892033463844863 1.1360239230847239e-07 6.944612522890591 -0.722785075291919 down VVTYGMANLLTGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVTYGMANLLTGPK 14 0 K7ESA3;Q99536-2;Q99536-3;Q99536 K7ESA3 VAT1 Synaptic vesicle membrane protein VAT-1 homolog 0 2772270.0 858360.0 839310.0 1074600.0 False True 1175718.8883067998 802226.5089729861 820801.612081705 1.0 0.6823285029708971 0.6981274352611401 20.165111725649897 -10.328010998506505 8.612253094684734 1.0000005054786947 0.690227969119627 0.9980529090158793 0.006449887098646022 6.259503402993837e-08 4.88405927623919e-09 0.0062450864722935024 0.002081692109831181 4.6988220868895e-11 10.328010998506505 -0.30977253635906765 VVVCDNGTGFVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVVCDNGTGFVK 12 0 P61160;P61160-2;A0A1B0GWD0;A0A1B0GWH0 P61160 ACTR2 Actin-related protein 2 0 31062300.0 5049500.0 18059000.0 7953800.0 False True 7660460.667898075 14836230.354388995 6381727.943725624 1.0 1.9367282200875595 0.8330736518847871 22.86899972169744 -6.681786974500486 1.8952619784489517 1.5917094026565 0.8371835061673127 0.33247208306914733 0.396850630451187 0.4345490394183052 3.0193080109836647 0.1679123988518449 0.4418911854329494 2.0807170479800832e-07 6.681786974500486 -0.7545258964891872 VVVCDNGTGFVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVVCDNGTGFVK 12 0 P61160;P61160-2;A0A1B0GWD0;A0A1B0GWH0 P61160 ACTR2 Actin-related protein 2 0 7339800.0 3203800.0 1987800.0 2148200.0 False True 2664101.65240505 1977091.326852593 2597378.6878454406 1.0 0.742123081177383 0.9749547978023382 21.34521770076591 -10.340238813215423 7.472827544626237 1.0000016609452724 0.8585389396036275 0.32984175828711737 0.09505315027790454 2.6303794501999625e-06 2.322520987969375e-07 0.09203589694124234 0.03067827233590625 4.568369115125145e-11 10.340238813215423 -0.14146272134164495 VVVCDNGTGFVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVVCDNGTGFVK 12 0 P61160;P61160-2;A0A1B0GWD0;A0A1B0GWH0 P61160 ACTR2 Actin-related protein 2 0 23328500.0 5049500.0 10487000.0 7792000.0 False True 6536677.290525692 9903389.231186125 6373935.952671627 1.0 1.5150494342959488 0.9751033544076065 22.640126043789888 -8.778195263515183 18.630587341370408 0.9999987395510705 1.2450763943517777 0.2154947795753741 0.22043206405828172 0.0 0.0 0.21343242826642 0.07114414275547332 1.6664977685909146e-09 8.778195263515183 0.2450776548007072 VVVFIKPTCPYCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVVFIKPTCPYCR 13 1 P35754 P35754 GLRX Glutaredoxin-1 0 154362000.0 38528000.0 39415000.0 76419000.0 False True 50510581.10568278 33534435.638466652 68511894.94280963 1.0 0.6639091236804995 1.3563869874999632 25.590082303752663 -6.774728755490853 1.5563373326935888 0.8083941387575229 1.3609991947021252 0.748321545186729 0.14184546638586867 0.2588515066942986 1.2379643636013002 0.07181231445942303 0.17021365174592087 1.6798528654440492e-07 6.774728755490853 0.5526050559446023 VVVFIKPTCPYCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVVFIKPTCPYCR 13 1 P35754 P35754 GLRX Glutaredoxin-1 0 107281000.0 38528000.0 28667000.0 40086000.0 False True 52772842.780050844 27400397.150908027 30618512.39708471 1.0 0.5192139689178523 0.5801944861052492 25.653292365275554 -10.279783481885552 5.59146433233084 1.0000423090132966 0.5497042275119555 0.9864320286110445 0.024895191893389877 1.3131550014602565e-05 1.6914611282407152e-06 0.024106923435262523 0.00803488863363996 5.250691689669274e-11 10.279783481885552 -0.45033808150134114 VVVHPLVLLSVVDHFNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVVHPLVLLSVVDHFNR 17 0 P51665;H3BNT7;H3BTM8;H3BQV2 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 68754340.0 43949740.0 14671600.0 10133000.0 False True 42554579.56057141 20530046.391383268 7478863.316516029 1.0 0.48244035315073847 0.17574755511027318 25.342811061782186 -8.551434684535772 0.28350836390436457 1.2012360058848806 5.231380495387329e-23 0.9989636539599716 0.010950231515298486 0.1912436311762922 0.07904782798787639 0.13327641252640188 0.10146958203966466 2.8090878121170044e-09 8.551434684535772 -1.2012360058848806 VVVHPLVLLSVVDHFNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVVHPLVLLSVVDHFNR 17 0 P51665;H3BNT7;H3BTM8;H3BQV2 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 139660900.0 28260000.0 55893100.0 55507800.0 False True 42872486.08274072 45918539.61021645 44536659.00006698 1.0 1.0710491461026328 1.038816804654494 25.353548742557184 -10.197540531657888 4.290183917896268 0.9999801788225168 1.0549329753810461 0.7947777244588264 0.013158798302226587 2.4956624328640166e-06 4.6681115517625447e-07 0.012745548540768138 0.004246983888887437 6.345406780647323e-11 10.197540531657888 0.05495279655852936 VVVHPLVLLSVVDHFNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVVHPLVLLSVVDHFNR 17 0 P51665;H3BNT7;H3BTM8;H3BQV2 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 38302240.0 2725850.0 10063590.0 25512800.0 False True 3733670.40832645 9618947.31795816 19487202.092609458 1.0 2.5762711396557574 5.219315033579583 21.832163147863156 -6.963339891022885 0.38548327666875054 0.8292777304477761 7.060592441431465 0.9998747294765471 0.019483594389367122 0.07852890714720062 0.016874853565764302 0.034227478246931294 0.22276716617394826 1.0880781995510316e-07 6.963339891022885 6.231314710983689 VVVHPLVLLSVVDHFNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVVHPLVLLSVVDHFNR 17 0 P51665;H3BNT7;H3BTM8;H3BQV2 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 95076200.0 43949740.0 27339990.0 23786470.0 False True 36546156.11360645 27192704.04730691 28760110.900788955 1.0 0.7440646825558442 0.7869531014803857 25.123216337216462 -10.232404370168481 5.4281382672175855 1.0000159775861035 0.7655088920181121 0.9755247620040594 0.017509123706715 3.3857802416478104e-06 4.788143525981902e-07 0.016954290490719982 0.005651045376888821 5.855926671852093e-11 10.232404370168481 -0.23450708556799138 VVVHPLVLLSVVDHFNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVVHPLVLLSVVDHFNR 17 0 P51665;H3BNT7;H3BTM8;H3BQV2 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 103747200.0 28260000.0 44669800.0 30817400.0 False True 36583127.08788113 42183886.36208996 25208949.413226712 1.0 1.1530967886029675 0.6890867845350942 25.124675064649633 -6.817794148857016 1.3813586234772421 1.082707739047288 0.6794259000938516 0.8792375159626405 0.06708622792533579 0.19636665620940394 0.7368436122894882 0.03816928992560425 0.08803141320959133 1.5212684245461585e-07 6.817794148857016 -0.4032818389534363 VVVLGLLPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVVLGLLPR 9 0 M0R389;Q15102 M0R389 PAFAH1B3 Platelet-activating factor acetylhydrolase IB subunit gamma 0 8933020.0 3371600.0 4983500.0 577920.0 False True 4420200.250620841 4239981.225530855 518122.3822000889 1.0 0.9592283120963416 0.11721694783563613 22.075680299581926 -6.928055808007485 0.857953751221921 1.0198524875476525 2.357819881221116e-19 0.9933190255248991 0.0332571243430411 0.09692163413638372 0.11621670550634738 0.028217875564425655 0.07938585958155057 1.1801689710244472e-07 6.928055808007485 -1.0198524875476525 down VVVLGLLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVVLGLLPR 9 0 M0R389;Q15102 M0R389 PAFAH1B3 Platelet-activating factor acetylhydrolase IB subunit gamma 0 9203500.0 4867200.0 2544200.0 1792100.0 False True 4712693.4001705805 3560112.327827729 1322695.2481524083 1.0 0.7554304991915806 0.2806665182387066 22.168120394441125 -6.9637483298994916 0.42732523463771055 1.019431773605675 1.5746210140559435e-20 0.9997932202977291 0.004294345303148528 0.07898535077228766 0.020308566294691396 0.006159155043996901 0.03919661147284744 1.087055380832882e-07 6.9637483298994916 -1.019431773605675 down VVVLGLLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVVLGLLPR 9 0 M0R389;Q15102 M0R389 PAFAH1B3 Platelet-activating factor acetylhydrolase IB subunit gamma 0 8360700.0 3214600.0 3111000.0 2035100.0 False True 4876783.218739502 2555817.74364606 1632861.5929839814 1.0 0.5240786044836047 0.33482349322183436 22.21749841288916 -13.999999999999998 0.12725960694630667 3.261569088041419 0.06032401819037599 0.999658192937097 0.005173629227936003 11.94181137385072 0.11065588528698432 6.773026033761252 0.24389997300105995 1.0000000000000041e-14 13.999999999999998 -3.2012450698510433 VVVLGLLPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVVLGLLPR 9 0 M0R389;Q15102 M0R389 PAFAH1B3 Platelet-activating factor acetylhydrolase IB subunit gamma 0 17084200.0 3371600.0 5855800.0 7856800.0 False True 4618171.634064035 5597071.393458929 6001185.655875249 1.0 1.2119669507677984 1.299472200558763 22.138890361104817 -13.962336282234425 0.1218173338153426 5.004387119408654e-17 1.4360207129736673 0.9996843030118845 0.0022339339793938265 11.81289155153521 0.10734841006002332 2.8590499864501897 0.12096392599157058 1.0905955411607308e-14 13.962336282234425 1.4360207129736673 VVVLGLLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVVLGLLPR 9 0 M0R389;Q15102 M0R389 PAFAH1B3 Platelet-activating factor acetylhydrolase IB subunit gamma 0 9429300.0 4867200.0 2039700.0 2522400.0 False True 4047292.4535195236 2028711.7312512514 3049822.1777401236 1.0 0.5012515785675643 0.7535462813140671 21.9485256698754 -10.264846844715589 4.8843962294137135 1.0000956007291055 0.6273989299404569 0.7441217674586513 0.10299888109066611 0.00010725581664683212 1.6143128212402444e-05 0.0997537084547324 0.03324274592832446 5.43441944176635e-11 10.264846844715589 -0.37269667078864865 VVVLGLLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVVLGLLPR 9 0 M0R389;Q15102 M0R389 PAFAH1B3 Platelet-activating factor acetylhydrolase IB subunit gamma 0 11359000.0 3214600.0 4805300.0 3339100.0 False True 4161363.0692393035 4537880.830801819 2731418.062059264 1.0 1.0904794307292547 0.6563758116300501 21.98862473498161 -6.852332804345938 1.2239468835766814 1.0483931666960489 0.6382417505005665 0.9436075508874122 0.044406294464051095 0.1549132758015732 0.4454291639292008 0.02837355086734629 0.065756754221424 1.4049704681258263e-07 6.852332804345938 -0.41015141619548234 VVVLMGSTSDLGHCEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVVLMGSTSDLGHCEK 16 0 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 19174200.0 5476300.0 7722100.0 5975800.0 False True 7179482.332564646 6569992.780510044 5357481.539921252 1.0 0.915106755080365 0.7462211468396299 22.775448393432946 -6.960148826289668 0.4333322777774566 1.0064760544374503 0.6483396135622495 0.999775673730347 0.0015798081471114823 0.07964800482394649 0.020935282808495482 0.0022096348283745554 0.014012222676920318 1.0961025136716786e-07 6.960148826289668 -0.3581364408752008 VVVLMGSTSDLGHCEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVVLMGSTSDLGHCEK 16 0 P22234;E9PBS1;P22234-2;D6RF62 P22234 PAICS Multifunctional protein ADE2;Phosphoribosylaminoimidazole-succinocarboxamide synthase;Phosphoribosylaminoimidazole carboxylase 0 17442400.0 5476300.0 7188000.0 4778100.0 False True 7501036.101442912 6870410.392462652 3649611.188058431 1.0 0.9159281863929503 0.4865476100503483 22.838658454955837 -6.9393325958346015 0.6657431600051265 1.0048795453486004 0.3729957004919901 0.9980751755396947 0.009865359411135114 0.08807241985646168 0.05600604842414369 0.009555308523032904 0.03706592309634755 1.1499194086237746e-07 6.9393325958346015 -0.6318838448566102 down VVVPPLPGK(ub)AFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVVPPLPGKAFLR 13 1 O60493;O60493-2;O60493-4 O60493 SNX3 Sorting nexin-3 1 6000500.0 1454900.0 2624800.0 1920800.0 True False 1907387.9892716424 2233190.0713902665 1722054.0416146368 1.0 1.170810597503571 0.9028336401930592 20.863166907082743 -6.734502811989076 1.7067047137268916 1.1022738403226662 0.9028542231155288 0.5800458780397305 0.07178300813795643 0.32786675428935363 1.8729017896414568 0.033302695961860626 0.08222386157666481 1.8428805565675737e-07 6.734502811989076 -0.1994196172071374 VVVPPLPGK(ub)AFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVVPPLPGKAFLR 13 1 O60493;O60493-2;O60493-4 O60493 SNX3 Sorting nexin-3 1 13919600.0 2479100.0 4970000.0 6470500.0 True False 2400402.3274907293 6954546.918207602 4775681.939160856 1.0 2.8972421991764885 1.9895339562318854 21.194844803170476 -10.007261726399312 6.0228154502042415 0.9999984854287821 2.4433880777043218 0.7712411972972303 0.37057033842257076 7.536434757661113e-06 1.2428130434046026e-06 0.3588035667723493 0.11960106244235168 9.834182727722098e-11 10.007261726399312 1.4433895922755395 VVVPPLPGK(ub)AFLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVVPPLPGKAFLR 13 1 O60493;O60493-2;O60493-4 O60493 SNX3 Sorting nexin-3 1 41691400.0 3792300.0 4833100.0 33066000.0 True False 5753196.354266733 3970595.5438173492 26530490.60665733 1.0 0.6901547069348056 4.611434926426867 22.45593227898535 -6.887788078259116 1.0353482873095081 0.7779983886362379 4.934477384185707 0.9794454874640961 0.2551927310428932 0.12095741494519177 0.232462559324233 0.18832364297932014 0.46591972995584824 1.2948275215083827e-07 6.887788078259116 4.1564789955494685 up VVVPPLPGK(ub)AFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVVPPLPGKAFLR 13 1 O60493;O60493-2;O60493-4 O60493 SNX3 Sorting nexin-3 1 6586300.0 1454900.0 2393500.0 2737900.0 True False 1992815.8471941426 2287747.2557539428 2091264.4088204915 1.0 1.1479973219678374 1.0494017356219658 20.926376968605634 -10.24018901452273 3.5493965153910705 0.9998023745252101 1.0986995288664518 0.5719445645575557 0.04025148002681969 28631975.98637204 58895583.54943643 66654.2013986085 0.014730531421449025 5.7518954769535555e-11 10.24018901452273 0.09889715434124169 VVVPPLPGK(ub)AFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVVPPLPGKAFLR 13 1 O60493;O60493-2;O60493-4 O60493 SNX3 Sorting nexin-3 1 12363700.0 2479100.0 5755100.0 4129500.0 True False 2061481.4927515292 5724096.134002092 4992959.357349285 1.0 2.776690527724286 2.4220248277296017 20.975250078604752 -9.956070326526444 5.599536161999372 0.9999977174324415 2.5993576777290057 0.964430372018894 0.1447916657162734 4.125839999364501e-06 7.689117438839702e-07 0.1401941279177043 0.04673130916467268 1.1064445997854218e-10 9.956070326526444 1.5993599602965642 VVVPPLPGK(ub)AFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVVPPLPGKAFLR 13 1 O60493;O60493-2;O60493-4 O60493 SNX3 Sorting nexin-3 1 26132400.0 3792300.0 5232100.0 17108000.0 True False 4909207.107408769 4940929.03561446 13994519.542903762 1.0 1.0064617213149996 2.850667987053107 22.2270586010778 -6.907668176966971 0.9114695759279728 0.9386039228193491 3.077483872661146 0.9900114103830724 0.08703972030349665 0.10598019871890749 0.14728167320670266 0.07044899242100254 0.19146773362622885 1.2368921208805523e-07 6.907668176966971 2.138879949841797 up VVVQVLAEEPEAVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVVQVLAEEPEAVLK 15 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 12972400.0 4194800.0 5980700.0 2796900.0 False True 5499423.42250098 5088402.872586007 2507503.6177592557 1.0 0.9252611558816738 0.4559575477494175 22.390848939033717 -6.934879585527115 0.7055868812036828 1.0060109825555044 0.34643377020025706 0.9974134056601243 0.012246181896969592 0.09018203382467849 0.06583957651003614 0.011500619816383527 0.041383995335282434 1.1617706870388012e-07 6.934879585527115 -0.6595772123552472 down VVVQVLAEEPEAVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVVQVLAEEPEAVLK 15 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 14251700.0 3855400.0 3772400.0 6623900.0 False True 3733012.4373392663 5278738.992806108 4888901.8772595 1.0 1.4140694898323376 1.3096398577080828 21.831908884624088 -10.092848190419504 5.094640913129725 0.9999913519227128 1.3618546737711343 0.9412070099351434 0.04263321879171202 29655390.70714809 0.05434720253070772 3008.520619582454 0.014594484769056861 8.075172521907696e-11 10.092848190419504 0.3618633218484215 VVVQVLAEEPEAVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVVQVLAEEPEAVLK 15 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 62854200.0 9167200.0 35961000.0 17726000.0 False True 13907312.61209133 29543478.585424587 14222448.33041822 1.0 2.124312540421276 1.0226597134267985 23.72934033098028 -6.641500737934297 2.0394248756882742 1.7344302681721748 1.0272941586765532 0.16017754773096904 0.4808873882553175 0.5296454799080712 4.212257504882796 0.19191483695600078 0.5323813193799327 2.282965045560957e-07 6.641500737934297 -0.7071361094956217 VVVQVLAEEPEAVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVVQVLAEEPEAVLK 15 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 13794800.0 4194800.0 4063300.0 5536700.0 False True 5745730.92020756 3883769.970463758 4229045.491915852 1.0 0.6759401065588814 0.7360326389532841 22.454059000556608 -10.689542622913347 6.733784521552712 1.0023867909337048 0.7059863727560847 0.969621276799099 0.024532673619659218 0.0008849884377478703 4.080184912753024e-05 0.023913755799309034 0.00791788636390685 2.043889332963123e-11 10.689542622913347 -0.2964004181776201 VVVQVLAEEPEAVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVVQVLAEEPEAVLK 15 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 10392700.0 3855400.0 2527300.0 4010000.0 False True 3205935.923179485 2513684.933270229 4848472.459854856 1.0 0.7840721067117535 1.512342285071745 21.612314160058364 -6.827266773588153 1.3399954598527277 0.8843838266995845 1.530878642677523 0.9003087281863839 0.09643104378715009 0.18421131066775184 0.6478368752535032 0.056516999546033786 0.13009078247199096 1.488446490468944e-07 6.827266773588153 0.6464948159779385 VVVQVLAEEPEAVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVVQVLAEEPEAVLK 15 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 30868500.0 9167200.0 13057000.0 8644300.0 False True 11867121.112527395 12330366.471974552 7071126.098008129 1.0 1.0390360353664998 0.5958585937530858 23.500466653072728 -6.885429476870971 1.0490132510860108 1.0264861930736051 0.560983161009397 0.9778091094780825 0.029845320138266625 0.12293108682135691 0.24412320758582942 0.021797238542052896 0.05352088858855441 1.30187870464724e-07 6.885429476870971 -0.46550303206420807 VVVQVLAEEPEAVLK(ub)GAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVVQVLAEEPEAVLKGAK 18 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 102308000.0 23582000.0 51226000.0 27500000.0 True False 30916230.368412863 43583280.47738406 24654563.798626836 1.0 1.4097216885119712 0.7974634522007064 24.881861085662575 -6.72637012066024 1.7365768175678487 1.2475587663752952 0.7980687652652309 0.5423424588975396 0.17229141699628608 0.34306827706574117 2.025147493967579 0.07867994256058965 0.1960380909800717 1.8777158808066542e-07 6.72637012066024 -0.4494900011100643 VVVQVLAEEPEAVLK(ub)GAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVVQVLAEEPEAVLKGAK 18 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 124969000.0 46979000.0 39383000.0 38607000.0 True False 45487677.360004514 55108837.27963179 28494668.514826197 1.0 1.2115113472046999 0.6264261041360712 25.438972435470017 -6.808891449626797 1.4190295093231209 1.1154229778888638 0.6164315646766654 0.8569635558767222 0.0914851197900569 0.20830810999854282 0.8268990417988468 0.050694731212288166 0.11733596319143931 1.5527750721084827e-07 6.808891449626797 -0.4989914132121984 VVVQVLAEEPEAVLK(ub)GAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVVQVLAEEPEAVLKGAK 18 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 120446000.0 54343000.0 39708000.0 26395000.0 True False 82442304.00546281 32621797.159979984 21178016.68066053 1.0 0.39569244884056604 0.2568828823519686 26.296881488482295 -13.999999999999877 0.20667151847324053 4.448000502073844 0.17243650194699417 0.9994884146555316 0.007296809254085829 12.670793518430802 0.14411450064503167 17.71261203789613 0.08418389678120115 1.0000000000002823e-14 13.999999999999877 -4.27556400012685 VVVQVLAEEPEAVLK(ub)GAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVVQVLAEEPEAVLKGAK 18 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 101750000.0 23582000.0 50386000.0 27782000.0 True False 32300902.67958779 48159779.9157795 21220463.78825041 1.0 1.4909731902388461 0.6569619430995176 24.945071147185466 -6.747189551640738 1.6603720850542634 1.28967192809711 0.6556659974343936 0.6367360557347044 0.20628750873133345 0.3049735614084204 1.6533222670942924 0.09818569005129195 0.23906417677479538 1.7898244989116908e-07 6.747189551640738 -0.6340059306627165 VVVQVLAEEPEAVLK(ub)GAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVVQVLAEEPEAVLKGAK 18 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 128099000.0 46979000.0 48269000.0 32851000.0 True False 39065120.02257847 48008965.31635366 39719992.21413769 1.0 1.2289470834495302 1.0167636037257974 25.219377710904293 -10.254672711896141 3.501984994530046 0.9997005125093427 1.1228553436154047 0.3089131076726551 0.08662354350861103 61704842.70363882 93744821.5123323 198281.99216595793 0.03170096456609934 5.563233494560117e-11 10.254672711896141 0.12315483110606207 VVVQVLAEEPEAVLK(ub)GAKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVVQVLAEEPEAVLKGAKPK 20 2 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 80965400.0 8312900.0 12099000.0 60553500.0 True False 10898292.402238114 10293876.361532629 54288004.69018737 1.0 0.9445402987553022 4.9813312660833535 23.377598768405225 -6.903788569295954 0.9370341379733496 0.8491619450750011 5.439185865054866 0.9883579824605633 0.20393027674186043 0.10866919564412988 0.16212115248627476 0.16199379195508043 0.430070405523346 1.2479909347700017e-07 6.903788569295954 4.590023919979865 up VVVQVLAEEPEAVLK(ub)GAKPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVVQVLAEEPEAVLKGAKPK 20 2 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 247405000.0 81654000.0 95325000.0 70426000.0 True False 79061938.46513993 133388769.61330779 51979317.865287416 1.0 1.6871426656471584 0.6574505871520744 26.236479992247382 -6.726849746450684 1.734603565182387 1.4149753053515868 0.6584035798474993 0.5445588119033484 0.2889393684181596 0.3422242445574656 2.0157628264121032 0.13207913517360723 0.3289349416141958 1.8756433151130906e-07 6.726849746450684 -0.7565717255040875 VVVQVLAEEPEAVLK(ub)GAKPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVVQVLAEEPEAVLKGAKPK 20 2 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 570747000.0 188798000.0 200850000.0 181099000.0 True False 286420368.98263615 165006748.2517873 145304703.27148867 1.0 0.5760999081102036 0.5073127438094236 28.093558853605053 -13.999999999999995 0.25591702224359514 4.038215793427138 0.48117060586722793 0.999554119021431 0.004600288229528683 14.240321651662253 0.16007583560555327 22.320148759506733 0.030733536450953954 1.0000000000000123e-14 13.999999999999995 -3.5570451875599103 VVVQVLAEEPEAVLK(ub)GAKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVVQVLAEEPEAVLKGAKPK 20 2 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 85333100.0 8312900.0 10921000.0 66099200.0 True False 11386403.777675569 10438474.109082455 50487930.31575559 1.0 0.9167489852720975 4.434054096583447 23.440808829928116 -6.90147940564883 0.9518646622198128 0.8596401224161108 4.814554808980609 0.9872881571742842 0.18476986929751324 0.1103246024175542 0.1713404898155601 0.1451707393685244 0.38059300353422154 1.2546442319855005e-07 6.90147940564883 3.954914686564498 up VVVQVLAEEPEAVLK(ub)GAKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVVQVLAEEPEAVLKGAKPK 20 2 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 248748000.0 81654000.0 103114000.0 63980000.0 True False 67898918.88553657 102558504.41547361 77357922.18990369 1.0 1.5104585772325165 1.1393100723785166 26.01688526768166 -10.204582507308809 9.530173618782165 0.9999999914639269 1.3248843248055167 0.5053537782079323 0.15152074261486426 2.7421587345154e-08 2.2939135446149383e-09 0.14670933146729145 0.04890310939602912 6.243347278392999e-11 10.204582507308809 0.3248843333415897 VVVQVLAEEPEAVLK(ub)GAKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVVQVLAEEPEAVLKGAKPK 20 2 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 438747000.0 188798000.0 166000000.0 83949000.0 True False 244402732.76496089 156761954.0742723 68671143.38948028 1.0 0.6414083521113013 0.2809753500404616 27.864685175697502 -7.444436200344691 0.3043915115209905 1.0819897898863495 4.018799117714872e-14 0.9997366899641086 0.00476323508282189 0.11991237913037135 0.028892470633990867 0.01966383327802692 0.06091701410479287 3.593881884886831e-08 7.444436200344691 -1.0819897898863093 down VVVTEK(ub)AAATAEEPDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVVTEKAAATAEEPDPK 17 1 Q99733;Q99733-2;C9J6D1;C9JZI7;E9PKT8;A8MXH2 Q99733 NAP1L4 Nucleosome assembly protein 1-like 4 1 7165100.0 2134000.0 2892900.0 2138200.0 True False 2797694.665685397 2461290.5964358766 1916959.5750626905 1.0 0.8797566891856992 0.6851925617812412 21.415807087817385 -6.963967486022639 0.37535448565879614 1.0140827414692881 0.5440366890868614 0.9998902471078022 0.0013588473484150256 0.07831314948130694 0.016106418817098896 0.00254552597379834 0.0164781392485506 1.0865069632193927e-07 6.963967486022639 -0.4700460523824267 VVVTEK(ub)AAATAEEPDPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVVTEKAAATAEEPDPK 17 1 Q99733;Q99733-2;C9J6D1;C9JZI7;E9PKT8;A8MXH2 Q99733 NAP1L4 Nucleosome assembly protein 1-like 4 1 11752800.0 2896600.0 3450300.0 5405900.0 True False 4394353.969825436 2834567.007683059 4337421.495509856 1.0 0.6450474921108054 0.987044176525943 22.067219654366134 -10.693827184946082 9.516278953060677 1.0002244314475093 0.8160458345985111 0.2783729365297797 0.13961956175678922 0.0006656076673203639 2.141484766564958e-05 0.13534772608609497 0.04506201979073522 2.0238243414204158e-11 10.693827184946082 -0.18417859684899818 VVVTEK(ub)AAATAEEPDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVVTEKAAATAEEPDPK 17 1 Q99733;Q99733-2;C9J6D1;C9JZI7;E9PKT8;A8MXH2 Q99733 NAP1L4 Nucleosome assembly protein 1-like 4 1 6383100.0 2134000.0 2063800.0 2185300.0 True False 2922997.469181593 1972614.491926046 1669177.147666248 1.0 0.6748601436450632 0.5710498094045902 21.479017149340276 -13.999999995653637 0.15974474864373714 2.600407253852888 0.4687111742422401 0.9995370404886013 0.003931564061986464 12.00793882632583 0.12629584202163394 5.954500407080968 0.09324226888780333 1.0000000100078713e-14 13.999999995653637 -2.131696079610648 VVVTEK(ub)AAATAEEPDPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVVTEKAAATAEEPDPK 17 1 Q99733;Q99733-2;C9J6D1;C9JZI7;E9PKT8;A8MXH2 Q99733 NAP1L4 Nucleosome assembly protein 1-like 4 1 9180900.0 1945400.0 4741400.0 2494100.0 True False 1617686.2958326936 4715857.137105791 3015604.7785845436 1.0 2.9151864296892827 1.864146828932788 20.625500434616114 -10.535113517942474 6.057358209404483 0.9978771168997341 2.3896666293109985 0.6997799658939601 0.4290851202186602 0.01230935743056024 0.0009447093465763925 0.41572798650239745 0.13848662705935644 2.916664542805287e-11 10.535113517942474 1.3917895124112643 VVVTEK(ub)AAATAEEPDPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVVTEKAAATAEEPDPK 17 1 Q99733;Q99733-2;C9J6D1;C9JZI7;E9PKT8;A8MXH2 Q99733 NAP1L4 Nucleosome assembly protein 1-like 4 1 16516800.0 2896600.0 5769600.0 7850600.0 True False 3749705.800522171 5448516.688113987 6421871.3539583925 1.0 1.453051780050383 1.7126333892819285 21.838345976458584 -9.989238646227045 0.11445461786550766 3.6064949914313075e-18 2.3065903778751555 0.9998872749191869 0.00312658707461762 1.5952498531902914 0.053737032401137926 0.792291273470742 0.3247357124264168 1.0250884820111975e-10 9.989238646227045 2.3065903778751555 VVVTMEHSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVVTMEHSAK 10 0 P55809;E9PDW2;P55809-2 P55809 OXCT1 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 0 16127000.0 6655200.0 3956800.0 5515000.0 False True 8725031.64904848 3366460.8634855985 4944360.703615536 1.0 0.38583938705285187 0.5666868502597066 23.056728933866232 -10.363839781519847 5.0124212763406435 1.0003391643084683 0.47626311865620186 0.9179152676763624 0.07383066768922802 0.0002800080986248633 3.5537789246469e-05 0.07153141761917757 0.023828745533269437 4.326734220394304e-11 10.363839781519847 -0.5240760456522664 VVVTMEHSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVVTMEHSAK 10 0 P55809;E9PDW2;P55809-2 P55809 OXCT1 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 0 9088200.0 2400100.0 1510900.0 5177200.0 False True 2323910.1392483157 2114210.2492394103 3821136.007329198 1.0 0.9097642002299047 1.6442701216343805 21.148122853140936 -6.876157498486293 1.101057438399737 0.946474733507171 1.6926252989843842 0.9704491572696236 0.05622311477291432 0.13108566562592025 0.2933477307925044 0.03946271285970869 0.09456216311630837 1.329972011283589e-07 6.876157498486293 0.7461505654772131 VVVTMEHSAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVVTMEHSAK 10 0 P55809;E9PDW2;P55809-2 P55809 OXCT1 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 0 12857800.0 2105200.0 8067800.0 2684800.0 False True 3193742.31073552 6628038.055990896 2154148.103210356 1.0 2.075320239116116 0.6744902667849414 21.606816481941294 -6.701638298628534 1.825235680671613 1.6666572577288286 0.6785531383063539 0.42530103246356155 0.4537707828679383 0.3921030908920498 2.5407787782943934 0.1982602537538255 0.508804993793822 1.9877497219114533e-07 6.701638298628534 -0.9881041194224747 VVVTMEHSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVVTMEHSAK 10 0 P55809;E9PDW2;P55809-2 P55809 OXCT1 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 0 14973600.0 6655200.0 2652000.0 5666400.0 False True 9115807.290017497 2534825.871008755 4328113.023171196 1.0 0.27806926916769975 0.4747920711214254 23.119938995389123 -10.392995361107788 5.250138400389822 1.0004055331699948 0.37643067014502296 0.9305397851916457 0.08031174759293919 0.0003814607080665086 4.410318859942751e-05 0.07781019350659395 0.025920505077678895 4.045802131752756e-11 10.392995361107788 -0.6239748630249718 VVVTMEHSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVVTMEHSAK 10 0 P55809;E9PDW2;P55809-2 P55809 OXCT1 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 0 6718800.0 2400100.0 2550300.0 1768400.0 False True 1995789.4924581284 2536561.027705084 2138164.2638422255 1.0 1.2709561991835674 1.071337569378993 20.928528128575213 -10.35788275571556 3.633267658985749 0.999206096645173 1.171146884200458 0.4949774159055558 0.08149396455536204 10156748.115015527 9921241.418028252 55891.73041572562 0.027897552486484255 4.3864910167092786e-11 10.35788275571556 0.17194078755528497 VVVTMEHSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVVTMEHSAK 10 0 P55809;E9PDW2;P55809-2 P55809 OXCT1 Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial 0 7237300.0 2105200.0 2825200.0 2306900.0 False True 2725222.8996959445 2667975.1364496034 1887067.8707928841 1.0 0.978993364816974 0.6924453302529587 21.377942804033744 -6.92162892309798 0.8125614574818073 1.005959027544774 0.6444612013028713 0.9946213988725556 0.010288991452077201 0.09722284131161606 0.10071954300264202 0.008942339593848183 0.027217969769100722 1.1977635066422328e-07 6.92162892309798 -0.36149782624190274 VVVVQAISALCQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVVVQAISALCQK 13 0 Q9Y678;Q9UBF2;Q9UBF2-2 Q9Y678;Q9UBF2 COPG1;COPG2 Coatomer subunit gamma-1;Coatomer subunit gamma-2 0 9113700.0 2215600.0 3910100.0 2988000.0 False True 2904673.0559009216 3326728.3214504276 2678830.422919894 1.0 1.1453021587720826 0.922248518633716 21.469944355268918 -6.730908652828528 1.7199853404210317 1.087352917127155 0.9223604008646542 0.5634724287599933 0.06107713172421039 0.33452289900135984 1.9392132102894093 0.028136221079201655 0.06974460097098653 1.8581952568123832e-07 6.730908652828528 -0.16499251626250078 VVVVQAISALCQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVVVQAISALCQK 13 0 Q9Y678;Q9UBF2;Q9UBF2-2 Q9Y678;Q9UBF2 COPG1;COPG2 Coatomer subunit gamma-1;Coatomer subunit gamma-2 0 8437700.0 2215600.0 3331900.0 2890200.0 False True 3034767.1943386775 3184685.640880121 2207594.2855374464 1.0 1.0494003120967943 0.7274344765739157 21.53315441679181 -6.8677496997744285 1.145865469853295 1.027595313043436 0.709362381319157 0.9623888284940433 0.027456718915301825 0.13903442825224394 0.3425874067228128 0.018619608508824353 0.04392067412088454 1.3559706840378516e-07 6.8677496997744285 -0.31823293172427913 VVYIFGPPVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VVYIFGPPVK 10 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 29019200.0 10234000.0 9170800.0 9614400.0 False True 13416873.106196987 7802552.387498408 8619594.115837023 1.0 0.5815477515319545 0.6424443346531916 23.677545145003002 -10.452521632730827 6.050915673444927 1.0001888385779072 0.611996043092629 0.981860528501175 0.024860925954335825 6.336350586047219e-05 5.733028343622926e-06 0.02408303546458321 0.00802382934936983 3.527592148201975e-11 10.452521632730827 -0.3881927954852782 VVYIFGPPVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVYIFGPPVK 10 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 30386400.0 12082000.0 5619400.0 12685000.0 False True 11698463.523352422 7863255.724783881 9362417.95815709 1.0 0.6721614089822381 0.8003117622641531 23.47981572284055 -10.192559470542335 4.796087850611235 1.0000353718992823 0.7362365856222418 0.8495886897744972 0.05231716265296655 1.979024963595495e-05 3.3317062648661167e-06 0.05066266041644717 0.016885291639180264 6.418603217149439e-11 10.192559470542335 -0.26379878627704045 VVYIFGPPVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVYIFGPPVK 10 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 36899000.0 10234000.0 10663000.0 16002000.0 False True 14017786.363451002 10191873.402174354 12222657.171534935 1.0 0.7270672514133852 0.8719391817386687 23.740755206525893 -10.131844001707133 4.681749577249924 1.0000172829696885 0.7995032165735295 0.7186102145700866 0.0591437179000536 1.0670247880886062e-05 1.978658618854116e-06 0.05727059340282191 0.01908855287043073 7.381693324537078e-11 10.131844001707133 -0.20051406639615899 VVYIFGPPVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVYIFGPPVK 10 0 P49915;P49915-2 P49915 GMPS GMP synthase [glutamine-hydrolyzing] 0 22837700.0 12082000.0 5851400.0 4904300.0 False True 10046718.32335282 5819877.346788035 5929766.455078847 1.0 0.5792814289677237 0.5902192401767216 23.260220998274825 -9.957545609262853 4.999641405903932 1.0000021702967423 0.5847503345712809 0.999479910209472 0.004465342760532384 1233993.4493441815 2457685.719575947 21.176231925154536 0.001528605374331144 1.1026924238826741e-10 9.957545609262853 -0.4152518357254614 VVYSAFLMATPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VVYSAFLMATPR 12 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 9560100.0 4966300.0 1875200.0 2718600.0 False True 4808647.5249151755 2623977.1390388138 2006517.1037481965 1.0 0.5456788266228976 0.4172726516867321 22.197199749500452 -13.999999999999998 0.1772435252788959 3.337826196316526 0.31231679130108875 0.9995017225041841 0.005580366044659678 12.170322704316064 0.13343262281265564 9.792699647115914 0.09816677974325458 1.0000000000000041e-14 13.999999999999998 -3.025509405015437 VVYSAFLMATPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VVYSAFLMATPR 12 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 30888000.0 4920000.0 13147000.0 12821000.0 False True 7463999.700179927 10800815.132020159 10286923.730356079 1.0 1.4470546042170653 1.378205271110622 22.831517497562487 -10.642381840561 6.4204389314132655 0.9979131310332967 1.4126299376638438 0.9795466517263913 0.02810762254028251 0.0008430685638545034 4.69588323084299e-05 0.027326676189306127 0.009071696166666518 2.278338029895429e-11 10.642381840561 0.4147168066305471 VVYSAFLMATPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VVYSAFLMATPR 12 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 11459200.0 2543300.0 3183200.0 5732700.0 False True 3483626.74009819 3042555.6985652614 4378754.328662562 1.0 0.8733873992709975 1.2569527837931174 21.732158621200792 -6.8177487404523855 1.3814486564862491 0.9315934081567062 1.2649369050355284 0.8791331034345986 0.05547774310089814 0.1964408655477448 0.7372131802424353 0.031561426524738125 0.07279616046619428 1.5214274916917964e-07 6.8177487404523855 0.33334349687882214 VVYSAFLMATPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VVYSAFLMATPR 12 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 11444600.0 4966300.0 2536700.0 3941600.0 False True 4129698.4943939014 2523034.293604471 4765770.336100733 1.0 0.6109487888836219 1.1540237967905658 21.97760502493473 -6.714394308041675 1.7793295744934712 0.7619023127069616 1.1529317956752558 0.4860131987249564 0.16383640917361325 0.3663247859644858 2.263361845273431 0.07319797707924071 0.18498779616314237 1.9302150252884554e-07 6.714394308041675 0.3910294829682942 VVYSAFLMATPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VVYSAFLMATPR 12 0 Q15029-2;Q15029;Q15029-3 Q15029-2 EFTUD2 116 kDa U5 small nuclear ribonucleoprotein component 0 30482800.0 4920000.0 15745000.0 9817800.0 False True 6369036.987699063 14868776.909032658 8031061.139134936 1.0 2.3345408321147607 1.2609537603009449 22.602643819654936 -6.592022747577608 2.221081448273031 1.9021054867171816 1.2641502290318118 0.0 0.5780060638099337 0.6637008554988788 6.175605704633838 0.2169921108028548 0.6439738548176687 2.558451876207303e-07 6.592022747577608 -0.6379552576853698 VWAHYEEQPVEEVMPVLEEK(ub)ER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VWAHYEEQPVEEVMPVLEEKER 22 1 Q7KZF4 Q7KZF4 SND1 Staphylococcal nuclease domain-containing protein 1 1 67375300.0 8625300.0 12918000.0 45832000.0 True False 11165620.880081428 12199101.944165366 37491046.27603256 1.0 1.0925592114566227 3.357721588318799 23.412560140692975 -6.915498609798083 0.8574394868615383 0.9414636645997048 3.6876941664157044 0.9928365914646465 0.09227787645747178 0.10089338512973998 0.11987152535400292 0.07766659647288494 0.22351700979104655 1.2147905090801328e-07 6.915498609798083 2.7462305018159996 up VWDLAQQVVLSSYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VWDLAQQVVLSSYR 14 0 Q9BQA1;H0Y711 Q9BQA1 WDR77 Methylosome protein 50 0 12828200.0 6311400.0 3546800.0 2970000.0 False True 5248208.742427498 3527692.6844153255 3591013.26827155 1.0 0.6721708029440217 0.6842359830776412 22.32339367222146 -9.93403318504958 5.562954925769333 1.000000378143039 0.6782033930163449 0.9989468046766506 0.00492558916597733 2.309975632043081e-08 4.432909797480932e-09 0.004769186815654973 0.0015897270671751344 1.1640370803086616e-10 9.93403318504958 -0.3217969851266942 VWGVPIPVFHHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VWGVPIPVFHHK 12 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 63671000.0 18076000.0 16019000.0 29576000.0 False True 23697811.04823298 13629027.641572937 26515759.233025033 1.0 0.5751175757893124 1.1189117500792198 24.49825046866396 -6.698209156392276 1.8369245002416843 0.7357129380360721 1.117259997433647 0.40927219111502056 0.17940625485868666 0.3992387447604771 2.61770336183837 0.0779481066530711 0.20093099644919776 2.0035069052733564e-07 6.698209156392276 0.38154705939757494 VWGVPIPVFHHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VWGVPIPVFHHK 12 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 67499600.0 20586000.0 9122600.0 37791000.0 False True 19932508.698206697 12765301.753730526 27892403.39430149 1.0 0.6404262477446707 1.3993423415292896 24.248619962882803 -6.777861329551405 1.5441708702628296 0.795835332559405 1.4049593652441061 0.7597622782888458 0.15192785463675623 0.2539105556024729 1.195704028699619 0.07750391846013227 0.1832088300783879 1.6677796504319322e-07 6.777861329551405 0.6091240326847012 VWGVPIPVFHHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VWGVPIPVFHHK 12 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 69560000.0 18076000.0 23536000.0 27948000.0 False True 24759185.68553253 22496101.696856022 21347258.00712772 1.0 0.9085961865862621 0.8621954808312419 24.561460530186853 -13.999999997301865 0.08726640159278588 1.4739002432969486 0.7405011825339496 0.9998550404034817 0.0006892576204472448 12.188620876990628 0.08515075151430092 1.082041620376117 0.10962324049124408 1.0000000062126856e-14 13.999999997301865 -0.733399060762999 VWGVPIPVFHHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VWGVPIPVFHHK 12 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 51050000.0 20586000.0 11396000.0 19068000.0 False True 17118171.11442985 11334607.486071121 23055030.6395293 1.0 0.6621389288787138 1.3468162273535718 24.02902523831708 -6.772546586470619 1.5648264549887116 0.8068384429777391 1.3510309391450455 0.7401372686741396 0.1424933787768484 0.26234577983872165 1.26815946037923 0.07176235845792049 0.17041984382166922 1.6883147454104352e-07 6.772546586470619 0.5441924961673064 VWGVPIPVFHHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VWGVPIPVFHHK 12 0 Q9NSE4 Q9NSE4 IARS2 Isoleucine--tRNA ligase, mitochondrial 0 33268700.0 5239700.0 15160000.0 12869000.0 False True 6782894.939928209 14316332.673288995 10526974.04709075 1.0 2.1106522804908017 1.5519883678460997 22.693469716444312 -9.970562902054914 5.244355077841459 0.9999966807900692 1.831320324172948 0.7469887789776746 0.22807358729676924 118472467.79672708 6.85340139754227 4748.562828941836 0.08346638642763783 1.0701313767107208e-10 9.970562902054914 0.8313236433828789 VWINTSDIILVGLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VWINTSDIILVGLR 14 0 O14602;P47813;X6RAC9 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 0 165497000.0 37930000.0 71477000.0 56090000.0 False True 57542583.05443579 58721370.89764998 45003786.91487971 1.0 1.0204854871061149 0.7820953548836299 25.778126648517482 -6.885991203211939 1.0457757980881914 1.0140667345874217 0.7631301267395988 0.9782070809428223 0.015924873973991695 0.12245727704432217 0.24131504119045152 0.011659261292690008 0.028678155769935338 1.3001959136938447e-07 6.885991203211939 -0.2509366078478229 VWINTSDIILVGLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VWINTSDIILVGLR 14 0 O14602;P47813;X6RAC9 O14602;P47813 EIF1AY;EIF1AX Eukaryotic translation initiation factor 1A, Y-chromosomal;Eukaryotic translation initiation factor 1A, X-chromosomal 0 96158000.0 37930000.0 31822000.0 26406000.0 False True 49101132.71207825 30051077.72621381 21600378.948440287 1.0 0.6120241238105212 0.43991610285452476 25.54925297060993 -13.99999999998544 0.11014831011860778 2.8715398384555035 0.12486345166449181 0.9997423090738244 0.003760288052217059 12.011766402742401 0.10073524846542652 4.998091980096754 0.2798215539518219 1.0000000000335275e-14 13.99999999998544 -2.7466763867910116 VWLDPNETNEIANANSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VWLDPNETNEIANANSR 17 0 J3QR09;J3KTE4;P84098 J3QR09 RPL19 Ribosomal protein L19;60S ribosomal protein L19 0 17861700.0 7246200.0 1856300.0 8759200.0 False True 7016173.347369342 2597530.2704766192 6464902.749632598 1.0 0.37022036684007276 0.9214285949842675 22.74225296196153 -10.422757596028042 8.651207736994927 1.0000035923164563 0.6458244809121826 0.35503996134613014 0.2250298168294825 1.5591698451986802e-05 1.040329988145752e-06 0.2178863931615408 0.07262806108172425 3.7778299384820736e-11 10.422757596028042 -0.3541791114042737 VWLDQK(ub)EDDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VWLDQKEDDKK 11 2 A0A590UJD8;Q5VVJ2;A0A590UJT8;A0A590UK32;A0A590UJW2 A0A590UJD8 MYSM1 Histone H2A deubiquitinase MYSM1 1 4298090.0 652690.0 1794600.0 1850800.0 True False 631970.7132144431 2511193.138715368 1366019.9571901576 1.0 3.973591000669139 2.161524147601811 19.269498177017528 -9.948882804080908 6.223182741510029 0.9999994056084639 3.067557574135651 0.6344793251809864 0.7397731949715968 6.102247905236439e-06 1.0256358790384883e-06 0.7162825080921226 0.23876077200787832 1.124908493592119e-10 9.948882804080908 2.067558168527187 VWLDQK(ub)EDDKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VWLDQKEDDKK 11 2 A0A590UJD8;Q5VVJ2;A0A590UJT8;A0A590UK32;A0A590UJW2 A0A590UJD8 MYSM1 Histone H2A deubiquitinase MYSM1 1 11430700.0 1369100.0 4355700.0 5705900.0 True False 2077024.7946171388 3578391.3037605677 4578126.364015191 1.0 1.722844769611996 2.2041751142691988 20.986087007874417 -8.262430099692972 0.13227811617498275 1.2475666515508584e-15 3.304946096683885 0.9999528103494136 0.0033996098913805064 0.08822955647998021 0.02803434080435918 0.3187872415842938 0.323370610103385 5.464744986422562e-09 8.262430099692972 3.3049460966838837 VWLDQK(ub)EDDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VWLDQKEDDKK 11 2 A0A590UJD8;Q5VVJ2;A0A590UJT8;A0A590UK32;A0A590UJW2 A0A590UJD8 MYSM1 Histone H2A deubiquitinase MYSM1 1 3090230.0 934630.0 1024400.0 1131200.0 True False 1280187.9684260518 979138.6207622057 864033.8577952957 1.0 0.7648397305014699 0.6749273380983234 20.287924224242058 -13.999999999999998 0.133213766797159 2.118465827029319 0.5540034612343927 0.9996313163633774 0.002631606724678151 11.933054297076632 0.11380671401666577 3.4852092232341394 0.10768627306792623 1.0000000000000041e-14 13.999999999999998 -1.5644623657949261 VWLDQK(ub)EDDKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VWLDQKEDDKK 11 2 A0A590UJD8;Q5VVJ2;A0A590UJT8;A0A590UK32;A0A590UJW2 A0A590UJD8 MYSM1 Histone H2A deubiquitinase MYSM1 1 3704990.0 652690.0 1632800.0 1419500.0 True False 542740.6540696209 1624003.7823145739 1716310.8869735587 1.0 2.9922280008643916 3.16230389985379 19.049903452451804 -10.349424464571284 0.5114510887446695 7.049707910358777e-21 3.1545351008187175 0.999553729602457 0.020738334135137523 1.701412218461559 0.24141907954546774 2.3809308179566893 0.03378162071414155 4.4727593827524045e-11 10.349424464571284 3.1545351008187175 VWLDQK(ub)EDDKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VWLDQKEDDKK 11 2 A0A590UJD8;Q5VVJ2;A0A590UJT8;A0A590UK32;A0A590UJW2 A0A590UJD8 MYSM1 Histone H2A deubiquitinase MYSM1 1 11755800.0 1369100.0 3547200.0 6839500.0 True False 1772326.9389956857 3349795.2017605943 5594781.179196294 1.0 1.8900548922755773 3.1567432938567515 20.757213329966866 -6.966116399975514 0.33834472207464156 0.8599481838787506 4.228840217510748 0.9999343432633281 0.007170650539438777 0.07758413162082765 0.013535281896055427 0.017973021944005386 0.10977135767046299 1.0811441432918054e-07 6.966116399975514 3.3688920336319974 VWNLANCK(ub)LK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VWNLANCKLK 10 1 P63244;J3KPE3;D6RAC2;H0Y8W2;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 15317100.0 4455500.0 6856100.0 4005500.0 True False 5841203.64712338 5833196.604868484 3591049.2834690847 1.0 0.9986292136452323 0.6147789908399394 22.477834252951922 -6.907683171607542 0.9113710943696506 1.0127730209133061 0.5675552369637955 0.9900174137629519 0.018111478174116905 0.10596997571886874 0.14722664126349724 0.014660303350937801 0.03984782896692997 1.2368494161413085e-07 6.907683171607542 -0.4452177839495106 VWNLANCK(ub)LK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VWNLANCKLK 10 1 P63244;J3KPE3;D6RAC2;H0Y8W2;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 31307000.0 4455500.0 6503500.0 20348000.0 True False 6102818.755360166 6216153.865801452 15542221.480214499 1.0 1.0185709448345885 2.546728340336769 22.541044314474814 -6.909552635845032 0.8987768737415363 0.9520131962692182 2.7423382511996937 0.9907516294273343 0.06970261959007862 0.10471456391031231 0.14037775100536962 0.05694054031859086 0.1566985335038633 1.2315367162732755e-07 6.909552635845032 1.7903250549304754 up VWNLANCK(ub)LK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VWNLANCKLK 10 1 P63244;J3KPE3;D6RAC2;H0Y8W2;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 12878400.0 0.0 1863400.0 11015000.0 True False 0.0 1853361.494344061 13318185.572394326 0.0 VWNLANCK(ub)LK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VWNLANCKLK 10 1 P63244;J3KPE3;D6RAC2;H0Y8W2;D6REE5;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;H0Y8R5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 1 207785000.0 11112000.0 15983000.0 180690000.0 True False 14384703.050266644 15093531.999813845 147806274.0359644 1.0 1.0492765785341716 10.275239851630067 23.778032103409725 -6.9080692340839995 0.908752834580508 0.6966119722138835 11.41969840790375 0.9901730849885383 0.432291742541858 0.10570938484150444 0.1457837126842073 0.35057873666346495 0.9553221594088463 1.2357504176598146e-07 6.9080692340839995 10.723086435689867 up VWNLNHLWGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VWNLNHLWGR 10 0 A6NC98-2;A6NC98-4;A6NC98 A6NC98-2 CCDC88B Coiled-coil domain-containing protein 88B 0 4727000.0 1392300.0 1150300.0 2184400.0 False True 1825318.7830523774 978679.7238342803 1958379.2422443805 1.0 0.5361692066728693 1.0728971073039053 20.799717014996943 -6.678028207108318 1.9082348925661987 0.7060319579511767 1.0708595002519594 0.3154960175248359 0.19666403822982204 0.44286861558229496 3.1159710423133236 0.08273681949377153 0.21881830722629872 2.098803563443328e-07 6.678028207108318 0.36482754230078274 VWNLNHLWGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VWNLNHLWGR 10 0 A6NC98-2;A6NC98-4;A6NC98 A6NC98-2 CCDC88B Coiled-coil domain-containing protein 88B 0 5095500.0 1392300.0 1889400.0 1813800.0 False True 1907070.9354927493 1805920.0605897245 1385417.7963835793 1.0 0.9469600878391607 0.726463693929463 20.862927076519835 -6.943990129485574 0.6213365203532615 1.0024111909331725 0.659304313343222 0.998641180856409 0.004365980306064961 0.0859926077633057 0.046668301903749806 0.004391527366841853 0.01867012111996194 1.1376531417682093e-07 6.943990129485574 -0.3431068775899505 VWNLNHLWGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VWNLNHLWGR 10 0 A6NC98-2;A6NC98-4;A6NC98 A6NC98-2 CCDC88B Coiled-coil domain-containing protein 88B 0 4666800.0 1548100.0 1105600.0 2013100.0 False True 1287313.7424584117 1099643.9133555815 2434029.9024772644 1.0 0.8542159359345974 1.8907821941129466 20.29593227752662 -6.8712935569689835 1.1272825253335328 0.9168748658182665 1.9529860281799858 0.96595461797114 0.08453734465038228 0.13561789339058025 0.3213178938703661 0.05815477371961272 0.1379961676580908 1.3449509407308387e-07 6.8712935569689835 1.0361111623617192 VWQLQDLSFQTAAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VWQLQDLSFQTAAR 14 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 6500200.0 1377000.0 2642500.0 2480700.0 False True 1805260.33488697 2248249.300384325 2224020.960554681 1.0 1.2453878573281183 1.2319668900795575 20.783775471127925 -10.025100428785224 4.508589423418261 0.9999906114721521 1.2386773737268635 0.9976341989624514 0.005479087009168728 2861670.922912217 0.16449547200818299 285.2754972051466 0.0020051405177414156 9.438425913906103e-11 10.025100428785224 0.23868676225471142 VWQLQDLSFQTAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VWQLQDLSFQTAAR 14 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 12152900.0 4465400.0 1236900.0 6450600.0 False True 4323648.321236383 1730800.6203482877 4760994.346148057 1.0 0.4003102222368888 1.1011520809321076 22.04381775062018 -6.680158599528739 1.9013067315127106 0.6206201437890972 1.0984875539711492 0.32482617325641927 0.25415457198337665 0.43818950823556213 3.0627217512511296 0.10725514012482106 0.2828225391331039 2.0885332823764083e-07 6.680158599528739 0.4778674101820519 VWQLQDLSFQTAAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VWQLQDLSFQTAAR 14 0 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 7482800.0 4465400.0 1351200.0 1666200.0 False True 3713177.950761442 1343920.817407798 2014594.7163616389 1.0 0.36193277974523336 0.542552698275211 21.824223026054455 -10.891728305650387 11.29183348975562 1.0328096954363544 0.45224273901022216 0.9246001915123085 0.07373777296358561 0.037368787404023295 0.00035830981220093185 0.043805217319469326 0.023798763889532552 1.2831330588350214e-11 10.891728305650387 -0.5805669564261322 VWQVTIGTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VWQVTIGTR 9 0 P63244;J3KPE3;D6RAC2;H0YAF8;D6RHH4;H0Y8R5;D6RF23;D6RHJ5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 1228710000.0 389150000.0 355440000.0 484120000.0 False True 510179418.533961 302409737.4942681 434027906.40695375 1.0 0.5927517389142535 0.8507358208493899 28.926429458552988 -10.516138125666117 5.9379712482850175 1.0003726378653637 0.7217437798818218 0.6080138104703452 0.10532156041690875 0.0005202523493395175 4.23933140786945e-05 0.10211107063687297 0.03399238745760547 3.046925772650059e-11 10.516138125666117 -0.27862885798354187 VWQVTIGTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VWQVTIGTR 9 0 P63244;J3KPE3;D6RAC2;H0YAF8;D6RHH4;H0Y8R5;D6RF23;D6RHJ5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 837050000.0 305780000.0 144620000.0 386650000.0 False True 296073181.27551 202367520.1833371 285374765.748635 1.0 0.68350506895464 0.9638656379453712 28.1413785741901 -10.25132265148535 7.523935496744905 1.0000004104764364 0.8236853540162212 0.3452622172193258 0.11445672300394191 7.880533583664607e-07 7.835599501173769e-08 0.11082250312410377 0.03694074850464521 5.6063131005330736e-11 10.25132265148535 -0.17631505646021517 VWQVTIGTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VWQVTIGTR 9 0 P63244;J3KPE3;D6RAC2;H0YAF8;D6RHH4;H0Y8R5;D6RF23;D6RHJ5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 1825020000.0 552540000.0 540500000.0 731980000.0 False True 838243576.0848396 444043552.0542253 587303832.1617692 1.0 0.5297309334933492 0.7006362457376321 29.642794281005752 -10.048498088726912 5.258212647056612 1.0000038199193777 0.6151835896147301 0.8711309398644714 0.06977180155758034 3.124501137046282e-06 5.654486153541313e-07 0.0675569271642647 0.022518752121899785 8.943384677902648e-11 10.048498088726912 -0.3848202303046476 VWQVTIGTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VWQVTIGTR 9 0 P63244;J3KPE3;D6RAC2;H0YAF8;D6RHH4;H0Y8R5;D6RF23;D6RHJ5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 1253810000.0 389150000.0 266910000.0 597750000.0 False True 533029271.3833259 255117033.6466621 456573761.04768175 1.0 0.47861730554605075 0.8565641430212161 28.98963952007588 -10.249100226210375 5.781732336959772 1.000015141595154 0.6675907242836336 0.5077266145039351 0.15429615028547317 3.0116626325498306e-05 3.911565481860213e-06 0.14940340237554817 0.049798868369960926 5.6350759488662954e-11 10.249100226210375 -0.3324244173115203 VWQVTIGTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VWQVTIGTR 9 0 P63244;J3KPE3;D6RAC2;H0YAF8;D6RHH4;H0Y8R5;D6RF23;D6RHJ5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 598920000.0 305780000.0 156860000.0 136280000.0 False True 254269618.35083866 156014964.0457279 164775517.91247383 1.0 0.6135808322583787 0.6480346294661057 27.921783849624376 -10.056110469944223 5.816466410664001 1.0000011944027354 0.6308077313654051 0.9935106254329513 0.014065703810208701 2.1785254466868338e-07 3.537926118692664e-08 0.013619103186790486 0.00453968638411122 8.787989514316026e-11 10.056110469944223 -0.36919346303733025 VWQVTIGTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VWQVTIGTR 9 0 P63244;J3KPE3;D6RAC2;H0YAF8;D6RHH4;H0Y8R5;D6RF23;D6RHJ5 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 2243020000.0 552540000.0 1007100000.0 683380000.0 False True 715273922.1917144 951053999.6879513 559011852.0709363 1.0 1.3296360599499684 0.781535345728856 29.4139206030982 -6.7438565316331065 1.6725090509625982 1.1952554641468442 0.7809341285512825 0.6220988135142592 0.13849415907129917 0.3109123559501901 1.709070313095832 0.06546881877371828 0.15998378521740406 1.803613462778254e-07 6.7438565316331065 -0.4143213355955617 VWQYITLMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VWQYITLMR 9 0 Q13823;H0YG10 Q13823 GNL2 Nucleolar GTP-binding protein 2 0 7299500.0 1399400.0 2809800.0 3090300.0 False True 1916795.9973630365 2685653.745233943 2360434.7867263104 1.0 1.4011161067367812 1.231448098792774 20.870265369943244 -10.218981211087558 5.352975705973249 0.9999791406863517 1.3162821027648264 0.8224833585175733 0.06926667418972102 1.7244448022238635e-05 2.5160591387389843e-06 0.06707158792594532 0.022355722965305684 6.039747586132414e-11 10.218981211087558 0.31630296207847464 VWTSQMK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 VWTSQMKR 8 1 C9K0D8;Q66S35;Q16877-2;Q16877-3;Q16877 C9K0D8 PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4;6-phosphofructo-2-kinase;Fructose-2,6-bisphosphatase 1 2149950.0 631890.0 903320.0 614740.0 True False 828413.9092314654 768548.177113781 551132.6018024681 1.0 0.9277345159822064 0.6652865139767676 19.659992251330333 -6.947096348484297 0.5898677234686039 1.003034696875242 0.5767834703123089 0.9989532107950934 0.004652874275741863 0.08467323737238465 0.04095350187168287 0.004824461117102947 0.021985703775617333 1.1295452965906069e-07 6.947096348484297 -0.426251226562933 VWTSQMK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VWTSQMKR 8 1 C9K0D8;Q66S35;Q16877-2;Q16877-3;Q16877 C9K0D8 PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4;6-phosphofructo-2-kinase;Fructose-2,6-bisphosphatase 1 1724000.0 631890.0 476640.0 615470.0 True False 865516.8091851727 455580.46876229777 470108.6620025374 1.0 0.5263681351159395 0.543153705408811 19.723202312853225 -9.92708595318286 7.06272618673825 1.0000000123020762 0.5347609202793202 0.9990246564758583 0.006852680376530476 1.3246346451011471e-09 1.95984587182639e-10 0.006635079441534663 0.0022116930812647205 1.1828074377948546e-10 9.92708595318286 -0.46523909202275604 VWWMFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VWWMFR 6 0 B1AH49;P25325;P25325-2;B1AH48;Q16762 B1AH49 MPST;TST Sulfurtransferase;3-mercaptopyruvate sulfurtransferase;Thiosulfate sulfurtransferase 0 4837800.0 1012200.0 2026600.0 1799000.0 False True 1327004.002158743 1724239.1796249296 1612856.737226536 1.0 1.2993473846499124 1.2154121122489259 20.33974129111432 -10.068118571200001 4.384920491631374 0.9999801645277948 1.2573797484285474 0.9261291499628374 0.03426643156487924 11982534.901839118 11070528.699878255 2770.345636365113 0.01254023042593029 8.548332941988483e-11 10.068118571200001 0.25739958390075257 VWWMFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VWWMFR 6 0 B1AH49;P25325;P25325-2;B1AH48;Q16762 B1AH49 MPST;TST Sulfurtransferase;3-mercaptopyruvate sulfurtransferase;Thiosulfate sulfurtransferase 0 6944100.0 1012200.0 2417600.0 3514300.0 False True 1386437.6936764794 2310782.438065905 2684294.7192804175 1.0 1.6667048570630671 1.9361091605655585 20.40295135263721 -10.6178543243728 0.1890022507085346 1.6154185061474463e-17 2.183974092894429 0.9994462614807693 0.009259018308275812 2.4415992879555772 0.09938363300497778 1.3021615735234728 0.17983249983906202 2.410713920124787e-11 10.6178543243728 2.183974092894429 VWYHVCSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VWYHVCSSR 9 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 18849500.0 6381600.0 6869500.0 5598400.0 False True 8366339.399502313 5844597.37710127 5019131.27164482 1.0 0.698584780991427 0.5999196341405171 22.99616509468442 -13.999999999999957 0.156132663860632 2.4729451549670314 0.4986657486283709 0.9995470776104444 0.0036217557399395367 11.98612017742636 0.12472673906849384 5.348899531148155 0.09185668648089748 1.0000000000000981e-14 13.999999999999957 -1.9742794063386606 VWYHVCSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VWYHVCSSR 9 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 6510830.0 3193800.0 855630.0 2461400.0 False True 3092414.5671977364 1197287.5210515046 1816685.4995828026 1.0 0.3871691505244896 0.5874650568694723 21.560302308363273 -10.043559887355961 5.192004985679544 1.0000055463464712 0.4873171036955205 0.8972840893549884 0.08177046135738496 5.2498148283774075e-06 9.672285887849886e-07 0.07917476433780048 0.02639130291999843 9.045656933880375e-11 10.043559887355961 -0.5126884426509507 VWYHVCSSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VWYHVCSSR 9 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 13150300.0 4803600.0 0.0 8346700.0 False True 7287412.39020006 0.0 6696971.086511424 1.0 0.0 0.9189779208210246 22.796975203557217 -9.38259208814186 12.455519056193317 0.9999996285407693 0.4594889604105087 0.3156550719811242 0.37517116514927984 0.0 0.0 0.36325791865007057 0.12108597288335683 4.1438870741569617e-10 9.38259208814186 -0.5405106681302606 VWYHVCSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VWYHVCSSR 9 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 13305100.0 6381600.0 3611300.0 3312200.0 False True 8741049.976255512 3451740.8250278733 2529926.576900259 1.0 0.3948885813951757 0.28943051278423515 23.059375156207313 -13.999999999999998 0.24577059322253836 5.120207003795688 0.24528823488099616 0.9995349216376092 0.006751849847843297 13.834234625262436 0.1568826254671195 28.069764843580526 0.04983973611525647 1.0000000000000041e-14 13.999999999999998 -4.874918768914692 VWYHVCSSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VWYHVCSSR 9 0 Q92499;F1T0B3;A0A087X2G1;Q92499-3 Q92499 DDX1 ATP-dependent RNA helicase DDX1 0 24280500.0 4803600.0 13628000.0 5848900.0 False True 6218354.8931120355 12869589.820025211 4784460.214781958 1.0 2.069613272520138 0.7694093207966664 22.568101525649666 -6.688114999141188 1.872889949801087 1.671746751910957 0.7739728595605077 0.3617367010889546 0.45254352195004816 0.42072204907014293 2.8597143051417544 0.19339661721832724 0.5048597385107879 2.0506191126081074e-07 6.688114999141188 -0.8977738923504494 VWYVSNIDGTHIAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VWYVSNIDGTHIAK 14 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7EPY4;K7ENA0 P06744 GPI Glucose-6-phosphate isomerase 0 71323400.0 20545100.0 29252300.0 21526000.0 False True 26934825.059031412 24887970.864572324 19298696.011972453 1.0 0.9240071472536717 0.7164960592718416 24.682969359153258 -6.953544059334121 0.5184777666532644 1.0035680926680208 0.6276986410020118 0.999450860808986 0.002807808796958003 0.08209306882914856 0.030308449489461868 0.0031886513071205107 0.01713802428562456 1.1128994830146973e-07 6.953544059334121 -0.37586945166600905 VWYVSNIDGTHIAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VWYVSNIDGTHIAK 14 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7EPY4;K7ENA0 P06744 GPI Glucose-6-phosphate isomerase 0 52665200.0 15121000.0 6526200.0 31018000.0 False True 14640992.13181693 9132145.693683399 22893455.27994615 1.0 0.6237381737155616 1.5636546399198903 23.803509983895946 -6.798070747610673 1.463760713928221 0.791881882694166 1.5760196143596077 0.8264389932832552 0.16091552816980634 0.22354063698220497 0.9457651562248011 0.0864911098913017 0.20138888235078384 1.591949373563488e-07 6.798070747610673 0.7841377316654417 VWYVSNIDGTHIAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VWYVSNIDGTHIAK 14 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7EPY4;K7ENA0 P06744 GPI Glucose-6-phosphate isomerase 0 136425600.0 11418000.0 116748000.0 8259600.0 False True 17321940.76761267 95913407.24371265 6627086.439688711 1.0 5.537105139110318 0.3825833680299592 24.04609724433106 -6.674287141041208 1.9222007572706017 3.8853125537314623 0.4030045330462235 0.2981244913469717 1.9253885088181046 0.45137165670932455 3.2192299689771993 0.8052343266606581 2.139409876932691 2.116961008357028e-07 6.674287141041208 -3.482308020685239 VWYVSNIDGTHIAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VWYVSNIDGTHIAK 14 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7EPY4;K7ENA0 P06744 GPI Glucose-6-phosphate isomerase 0 80816700.0 20545100.0 30208100.0 30063500.0 False True 28141178.68045114 28873406.257171847 22963120.477217853 1.0 1.0260197906077533 0.8159971100702212 24.74617942067615 -6.875876388479838 1.102602576078933 1.0153920539578136 0.8022451493321628 0.9702012992211153 0.016136492080575004 0.13134234954271756 0.2949294194352294 0.011312779921668311 0.027091200487703724 1.330833153851822e-07 6.875876388479838 -0.21314690462565078 VWYVSNIDGTHIAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VWYVSNIDGTHIAK 14 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7EPY4;K7ENA0 P06744 GPI Glucose-6-phosphate isomerase 0 32860900.0 15121000.0 10833000.0 6906900.0 False True 12573781.473879999 10774640.478817858 8351100.856102621 1.0 0.8569132922502617 0.6641678061170926 23.583915259330222 -6.966983100707423 0.32221395469037206 1.0257199862115396 0.4891239522767948 0.9999483742637327 0.0009886653654847444 0.0772943788547797 0.012520859120301613 0.0028958940866747 0.016921483106167094 1.0789887070853792e-07 6.966983100707423 -0.5365960339347449 VWYVSNIDGTHIAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VWYVSNIDGTHIAK 14 0 P06744;A0A2U3TZU2;P06744-2;K7EQ48;A0A2R8Y6C7;A0A0J9YYH3;A0A0J9YXP8;A0A0J9YX90;K7EPY4;K7ENA0 P06744 GPI Glucose-6-phosphate isomerase 0 34996600.0 11418000.0 14847000.0 8731600.0 False True 14780826.082428422 14020751.398438089 7142538.393781772 1.0 0.9485769821150987 0.48322998687285046 23.81722356642351 -6.927879784018943 0.7640094443156161 1.0076615184312638 0.3926624197263637 0.9961045191062564 0.014507283889008998 0.09375436618998577 0.08318832091082268 0.013053685167904155 0.04260755658542938 1.1806474025103549e-07 6.927879784018943 -0.6149990987049001 down VYADGIFDLFHSGHAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYADGIFDLFHSGHAR 16 0 C9J050;C9JEJ2;P49585;H7C1T3;C9J2E1;C9JPY0;Q9Y5K3-2;Q9Y5K3-4;Q9Y5K3-3;Q9Y5K3;C9JVS0;F8WAZ5;F2Z2B1 C9J050 PCYT1A;PCYT1B Choline-phosphate cytidylyltransferase A;Choline-phosphate cytidylyltransferase B 0 4595800.0 1426600.0 1517600.0 1651600.0 False True 1870286.4152140524 1291179.9955584686 1480708.2752658958 1.0 0.6903648473598598 0.7917013475695006 20.834827790329015 -10.696627730741005 9.749416693340956 1.000285457590771 0.7410330974646803 0.8969872843356888 0.04137045297217676 0.00025696459404453615 7.995903876593209e-06 0.04009927800037863 0.013352256282191482 2.0108157084053287e-11 10.696627730741005 -0.25925236012609065 VYADGIFDLFHSGHAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYADGIFDLFHSGHAR 16 0 C9J050;C9JEJ2;P49585;H7C1T3;C9J2E1;C9JPY0;Q9Y5K3-2;Q9Y5K3-4;Q9Y5K3-3;Q9Y5K3;C9JVS0;F8WAZ5;F2Z2B1 C9J050 PCYT1A;PCYT1B Choline-phosphate cytidylyltransferase A;Choline-phosphate cytidylyltransferase B 0 4354810.0 1632800.0 959410.0 1762600.0 False True 1580967.657749531 1342507.4162570564 1300922.1831334382 1.0 0.8491681722117472 0.8228645138669498 20.592376423749347 -13.99999999973007 0.24567947622452643 2.0265507767048154 0.8118448854251112 0.9995347532749703 0.0016833864135400202 13.830764781740193 0.1568534940142263 6.988867702237636 0.012437595480012931 1.0000000006215364e-14 13.99999999973007 -1.2147058912797042 VYADGIFDLFHSGHAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYADGIFDLFHSGHAR 16 0 C9J050;C9JEJ2;P49585;H7C1T3;C9J2E1;C9JPY0;Q9Y5K3-2;Q9Y5K3-4;Q9Y5K3-3;Q9Y5K3;C9JVS0;F8WAZ5;F2Z2B1 C9J050 PCYT1A;PCYT1B Choline-phosphate cytidylyltransferase A;Choline-phosphate cytidylyltransferase B 0 6256000.0 1426600.0 2171100.0 2658300.0 False True 1954052.5724153987 2075173.623132395 2030464.2894070302 1.0 1.0619845404503518 1.0391042278341465 20.898037851851907 -10.217241670017724 5.871258361431625 0.9999987180489145 1.0505443841422495 0.8667855911128528 0.009340848510846596 1.567496360357901e-07 2.091227555892213e-08 0.009044467061797028 0.0030147458934959683 6.063987955052569e-11 10.217241670017724 0.050545666093334995 VYAILTHGIFSGPAISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYAILTHGIFSGPAISR 17 0 B1ALA9;P60891;A0A2R8Y7H4;P60891-2;B7ZB02;P11908;P11908-2;H7C540 B1ALA9;P11908 PRPS1;PRPS2 Ribose-phosphate pyrophosphokinase 1;Ribose-phosphate pyrophosphokinase 2 0 242870000.0 83380000.0 77191000.0 82299000.0 False True 80733147.53990455 108013768.84574726 60742422.98292239 1.0 1.337911033288508 0.7523851705756771 26.266657803299744 -6.750215612013746 1.648948373224097 1.1986450299696658 0.7511964059315721 0.6499153670776618 0.14199452076635993 0.29968111116306545 1.6032515907319433 0.06802153483820506 0.16510690863597083 1.7773967756527802e-07 6.750215612013746 -0.4474486240380937 VYAILTHGIFSGPAISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYAILTHGIFSGPAISR 17 0 B1ALA9;P60891;A0A2R8Y7H4;P60891-2;B7ZB02;P11908;P11908-2;H7C540 B1ALA9;P11908 PRPS1;PRPS2 Ribose-phosphate pyrophosphokinase 1;Ribose-phosphate pyrophosphokinase 2 0 411930000.0 119810000.0 125170000.0 166950000.0 False True 181760529.28425947 102832435.54232621 133952259.3232155 1.0 0.5657577910191063 0.7369711116637677 27.437463700169143 -10.112224875029066 5.171720086468949 1.0000089340262017 0.6513644513409506 0.8468253544840955 0.06989754545952044 7.2003953052306775e-06 1.2359677639544771e-06 0.06767974019706613 0.02255933579188094 7.72280599374058e-11 10.112224875029066 -0.34864448268525117 VYAILTHGIFSGPAISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYAILTHGIFSGPAISR 17 0 B1ALA9;P60891;A0A2R8Y7H4;P60891-2;B7ZB02;P11908;P11908-2;H7C540 B1ALA9;P11908 PRPS1;PRPS2 Ribose-phosphate pyrophosphokinase 1;Ribose-phosphate pyrophosphokinase 2 0 217330000.0 83380000.0 71831000.0 62119000.0 False True 69334164.36030124 71444032.14566284 75107795.69419543 1.0 1.030430420627809 1.0832725307525306 26.04706307873402 -6.962711991878947 0.39537920783004254 0.9969429382772084 1.11867509078313 0.9998578743008639 0.00041010976594368746 0.07874641478494453 0.01765470541868932 0.0006806269626696857 0.004435166272870968 1.0896524712061935e-07 6.962711991878947 0.12173215250592162 VYALPEDLVEVK(ub)PK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYALPEDLVEVKPK 14 1 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 1 10574900.0 3091200.0 3064200.0 4419500.0 True False 2993071.548037335 4287751.039591908 3261900.3678419557 1.0 1.4325588181824593 1.0898170376117142 21.513195335552403 -9.95200879853287 5.4641519527044595 0.9999995095780191 1.261187927897741 0.43639834694992896 0.13992374599084756 8.361728059959585e-07 1.601640849034598e-07 0.13548083885560339 0.045160194829792465 1.116840621063289e-10 9.95200879853287 0.26118841831972184 VYALPEDLVEVK(ub)PK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYALPEDLVEVKPK 14 1 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 1 6366700.0 2611100.0 1326600.0 2429000.0 True False 3576494.232324302 1267986.4255204438 1855320.2268252946 1.0 0.3545333343642501 0.5187538707757271 21.770114684272368 -10.513232425664105 9.48028880466749 1.0000136799983559 0.43664360257109963 0.9400874255004891 0.06704275324904405 1.9385270413222818e-05 9.953695267697745e-07 0.06491543663767814 0.021637955568120065 3.067379949036627e-11 10.513232425664105 -0.5633700774272563 VYALPEDLVEVNPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYALPEDLVEVNPK 14 0 P13796;P13796-2 P13796 LCP1 Plastin-2 0 25275800.0 1294800.0 12010000.0 11971000.0 False True 1697495.3388610382 10218154.814613335 10732355.75394044 1.0 6.019548083984354 6.3224655221389225 20.69497618231477 -9.923799737498332 0.6699090294643507 1.2728994410017137e-18 6.2762197326848 0.9996498394689187 0.04567311169620815 1.1936005281249689 0.3269457124102116 2.6637566062117406 0.04841489743467193 1.191791441938787e-10 9.923799737498332 6.2762197326848 VYALPEDLVEVNPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYALPEDLVEVNPK 14 0 P13796;P13796-2 P13796 LCP1 Plastin-2 0 23224200.0 9983100.0 3734300.0 9506800.0 False True 9666191.954972655 5225425.4641172355 7016683.882113354 1.0 0.5405878021519197 0.7258994974234613 23.204516213969534 -10.176436502168583 5.33020521935702 1.0000149491048353 0.6332436497875834 0.8392959669654538 0.07565318279794254 1.3440219168742562e-05 2.0766455001812244e-06 0.07325386214068369 0.02441695975528054 6.661369094967475e-11 10.176436502168583 -0.36677129931725194 VYALPEDLVEVNPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYALPEDLVEVNPK 14 0 P13796;P13796-2 P13796 LCP1 Plastin-2 0 26729800.0 1294800.0 12173000.0 13262000.0 False True 1773522.5506543254 11635156.609272111 10129788.739463571 1.0 6.5604785261847525 5.711677438624209 20.758186243837663 -10.476465568148493 5.5321834325109265 0.9934785660883679 6.136077982404492 0.9799273922540399 0.34652159294050133 0.027714654371474322 0.0026227525590094684 0.3336212101194602 0.11183936321331281 3.338369714690631e-11 10.476465568148493 5.142599416316124 VYATILNAGTNTDGFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYATILNAGTNTDGFK 16 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 38264000.0 10373000.0 13302000.0 14589000.0 False True 13599103.452274878 11317393.450789886 13079470.227569727 1.0 0.8322161450206995 0.9617891556948024 23.69700820630535 -10.573163510633435 4.73331608697467 1.0009828200955238 0.8970026503577427 0.4572544849869936 0.05289796009798643 0.0005538045942933435 4.994033718685828e-05 0.05170124017702827 0.01707274320898317 2.6720002188019776e-11 10.573163510633435 -0.10398016973778101 VYATILNAGTNTDGFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYATILNAGTNTDGFK 16 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 17260400.0 4432700.0 2773700.0 10054000.0 False True 4291986.364837306 3881252.8746544155 7420555.78646523 1.0 0.9043022378757115 1.7289327494745008 22.033214062144413 -6.877997984999335 1.0909454746055494 0.9421268315961373 1.7851662502922268 0.9720325073222718 0.06158533903986726 0.12941628276129513 0.2831513955025584 0.04356239462265851 0.10482611657890621 1.3243476797702366e-07 6.877997984999335 0.8430394186960894 VYATILNAGTNTDGFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYATILNAGTNTDGFK 16 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 29370400.0 10373000.0 8261400.0 10736000.0 False True 14208178.419784738 7896384.03120352 8200377.914860576 1.0 0.5557632933584146 0.5771589905882402 23.760218267828243 -10.114417521814847 5.050157529607047 1.0000146115740205 0.5664611419722709 0.9981766682423217 0.008734756821072566 1.4370447576543999e-06 2.5199664699904147e-07 0.008457676683442841 0.002819130641233283 7.683913693639545e-11 10.114417521814847 -0.43355346960174956 VYATILNAGTNTDGFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYATILNAGTNTDGFK 16 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 14165700.0 4432700.0 5677700.0 4055300.0 False True 3685986.4519058173 5647113.103164786 4903244.480411322 1.0 1.5320493379038276 1.330239420135722 21.81361933757869 -10.083689898975077 4.454166109329556 0.9999689053849529 1.431144378880241 0.8588675123604949 0.08238855406338455 28628471.046701882 1.241911992395894 10495.473422287385 0.028203793442280876 8.24726787786776e-11 10.083689898975077 0.43117547349528806 VYATILNAGTNTDGFK(ub)EQGVTFPSGDIQEQLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYATILNAGTNTDGFKEQGVTFPSGDIQEQLIR 33 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 77340600.0 8966600.0 11645000.0 56729000.0 True False 13602987.74626693 9566858.76719972 45516488.28479599 1.0 0.7032909935411178 3.3460655213254227 23.69742022254902 -6.879015191253427 1.0853166644412593 0.818409949549171 3.52982670124612 0.9728806051493964 0.1946684082856869 0.128504153592363 0.2776098188473521 0.1382932505067855 0.33359686764936947 1.3212494171918436e-07 6.879015191253427 2.711416751696949 up VYATILNAGTNTDGFK(ub)EQGVTFPSGDIQEQLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYATILNAGTNTDGFKEQGVTFPSGDIQEQLIR 33 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 59697600.0 8966600.0 11830000.0 38901000.0 True False 11607440.458110241 11171650.100594234 31821417.157967016 1.0 0.9624559471927753 2.7414671884647106 23.46854654464147 -6.902079668628148 0.9480211004891026 0.9301964191720111 2.9362998143257832 0.987573023838584 0.09251714949042535 0.10989081112306483 0.168909650407214 0.07289617706812276 0.19172225811653498 1.252911315051751e-07 6.902079668628148 2.0061033951537723 up VYEGERPLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYEGERPLTK 10 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 48930130.0 966530.0 26622200.0 21341400.0 False True 1267130.1898898336 22650271.53252284 19133196.64916417 1.0 17.8752520563748 15.099629700108117 20.27313332952445 -9.564455748002768 8.896855318212827 0.9999803139284824 16.487440878656177 0.9764774229062293 1.133143081976231 0.0 0.0 1.0971610713152313 0.36572035710507705 2.726115499560389e-10 9.564455748002768 15.487460564727694 VYEGERPLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYEGERPLTK 10 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 51492700.0 17482500.0 5589100.0 28421100.0 False True 16927527.60693668 7820856.77677145 20976761.295276195 1.0 0.4620200278726213 1.2392099887452077 24.012867936341376 -6.720534510310718 1.7577831828928625 0.6728802958535628 1.2380029816317442 0.5148819352733685 0.2263689885643184 0.35427009171291307 2.139621871341202 0.10225128286139995 0.256489815898173 1.9031170043200985e-07 6.720534510310718 0.5651226857781814 VYEGERPLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYEGERPLTK 10 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 200822000.0 1474000.0 198237000.0 1111000.0 False True 2236165.763834389 162860058.51724955 891410.3630314025 1.0 72.83004737448033 0.3986334007291512 21.092595706430952 -3.011942721755202 1.1433788921053774e-10 9.55033927643396 56.555484627215975 0.0 35.004340558259976 228464404.0408546 0.30212728380196946 461842567.52375877 461842542.2927793 0.0009728755259551248 3.011942721755202 47.005145350782016 VYEGERPLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYEGERPLTK 10 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 48329630.0 966530.0 25135900.0 22227200.0 False True 1323882.2604911355 24025312.824694205 16977593.143553372 1.0 18.147620480828305 12.824095956429693 20.33634339104734 -9.2866721895831 12.320734361795319 1.0000000363149713 15.485858218629271 0.9080251287402216 2.1733197863281837 0.0 0.0 2.10430764646827 0.7014359448693428 5.168063133726527e-10 9.2866721895831 14.485858182314301 VYEGERPLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYEGERPLTK 10 1 P11021 P11021 HSPA5 78 kDa glucose-regulated protein 0 5099600.0 1474000.0 1553200.0 2072400.0 False True 1908122.0568838217 1466763.0546274679 1695244.4646196961 1.0 0.7686945650755996 0.8884360717407257 20.8637220285234 -10.139425743184654 4.423479246627859 1.0000241743401628 0.8285653184003992 0.7321221143567987 0.0488842654403267 10924185.517183393 25040237.885261398 1649.258109849015 0.016734384367941765 7.253944973517214e-11 10.139425743184654 -0.17145885593976362 VYFDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYFDLR 6 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 187105000.0 59626000.0 56447000.0 71032000.0 False True 78170263.41900532 48025327.628682636 63682290.02705684 1.0 0.6143682460331376 0.8146613205805565 26.2201165636009 -10.103377161158877 4.843805078201153 1.000012957383038 0.7145147833046563 0.7303697286931307 0.08176930528328889 1.1442407948862106e-05 2.11796316519823e-06 0.07917638137910137 0.02639092979835213 7.881753328636298e-11 10.103377161158877 -0.28549817407838174 VYFDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYFDLR 6 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 98150000.0 39800000.0 16834000.0 41516000.0 False True 38536570.785418585 23555903.9881503 30641714.14669687 1.0 0.6112610309649905 0.7951333894579701 25.199724861922366 -10.121374403685714 5.14936764347058 1.0000088736391044 0.7031972102110658 0.7764911547501971 0.07506557601976178 7.647355053607147e-06 1.3048344840861703e-06 0.07268410380031279 0.02422731048295943 7.561807133101602e-11 10.121374403685714 -0.29681166342803855 VYFDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYFDLR 6 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 182622000.0 43727000.0 110300000.0 28595000.0 False True 66337055.871903956 90616103.22216655 22943185.716366276 1.0 1.3659952500325783 0.34585776252520595 25.983311649004687 -6.809670255639569 1.4158440025798917 1.1995420302696862 0.3281321712405034 0.8589850814757081 0.15845832047435393 0.2072491729943285 0.8188768377826354 0.08800181795739592 0.2036039699782155 1.5499930268548244e-07 6.809670255639569 -0.8714098590291828 down VYFDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYFDLR 6 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 170802000.0 59626000.0 51349000.0 59827000.0 False True 81671343.53206258 49080231.39156441 45697094.7757418 1.0 0.6009480102686993 0.5595242198728128 26.28332662512379 -13.999999999999977 0.32006247352081957 5.093163333390335 0.5513060639892003 0.9996938604971173 0.0034748666576392057 18.018064733322856 0.18042176898662857 49.38648358318902 0.013788023683597746 1.0000000000000532e-14 13.999999999999977 -4.5418572694011345 VYFDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYFDLR 6 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 90391000.0 39800000.0 35836000.0 14755000.0 False True 33095463.43895407 35642944.355110906 17840202.28058813 1.0 1.0769737193998135 0.5390528014057006 24.980130137356642 -6.870610368415613 1.1308099212864766 1.0437021284587893 0.5071748183100101 0.9652912053378104 0.04425130877768567 0.13627367025399412 0.32530630231004776 0.030357478505102085 0.07195254661209627 1.347068347767677e-07 6.870610368415613 -0.5365273101487792 VYFDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYFDLR 6 0 P23284 P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 0 143236000.0 43727000.0 59144000.0 40365000.0 False True 56605463.488031864 55852584.40824561 33018984.179875527 1.0 0.986699533341946 0.5833179722458549 25.754437971097136 -6.9139121522457945 0.86866028042589 1.0109978544978098 0.5265764209738274 0.9923162340320075 0.016949996410702065 0.1018877794345628 0.12515199455120266 0.014151401852215419 0.0402093705796074 1.2192361973375134e-07 6.9139121522457945 -0.48442143352398237 VYFPYLLISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYFPYLLISK 10 0 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y705;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 19334400.0 4754100.0 6067200.0 8513100.0 False True 6232671.138769889 5161997.409760374 7632246.075421473 1.0 0.8282159117381526 1.2245545939277347 22.571419161588057 -6.788883403342207 1.500598726731731 0.9038526661887788 1.2286534178015374 0.7977682990844255 0.07297848462269882 0.23700617553454237 1.0543122072099618 0.03828094951154155 0.08970594221800728 1.6259852314704513e-07 6.788883403342207 0.32480075161275856 VYFPYLLISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYFPYLLISK 10 0 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y705;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 12556000.0 4821500.0 2710500.0 5024000.0 False True 4668444.121655665 3792816.785070769 3708063.68323068 1.0 0.8124370103257539 0.7942825460906693 22.15451038436085 -13.99999999985599 0.3302161502827932 3.044408784679081 0.7910755301380307 0.9997152869779701 0.0015690997785324928 18.8416619916188 0.18376882875967446 26.75556549299786 0.005812948329174799 1.0000000003315936e-14 13.99999999985599 -2.2533332545410505 VYFPYLLISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYFPYLLISK 10 0 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y705;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 19531500.0 4754100.0 6699000.0 8078400.0 False True 6511819.244721747 6403016.029369414 6170448.299870498 1.0 0.9832914257501043 0.947576716732739 22.63462922311095 -6.95872512621246 0.45306286551002994 1.0011163471741034 0.9283287415014577 0.9997198256970017 0.00036594884306840843 0.0801599931931229 0.022839939948466604 0.0004795942090451918 0.0029528984152489496 1.0997016426931104e-07 6.95872512621246 -0.07278760567264564 VYFPYLLISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYFPYLLISK 10 0 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y705;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 10952700.0 4821500.0 2340200.0 3791000.0 False True 4009290.8786662524 2327592.878106667 4583680.572396452 1.0 0.5805497651696886 1.1432646597897327 21.934915659795127 -6.707106153295513 1.8056923009506676 0.741391832368298 1.1418317019334858 0.45152727156155037 0.17683248907261379 0.38078638446284163 2.4184084662504364 0.07799032243765575 0.1988177068948953 1.9628804372271338e-07 6.707106153295513 0.40043986956518784 VYFPYLLISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYFPYLLISK 10 0 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y705;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 0 9883300.0 0.0 5684600.0 4198700.0 False True 0.0 5368247.012835 3434579.6823000913 0.0 VYFPYLLISKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYFPYLLISKK 11 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y705;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 2798790.0 712390.0 1025600.0 1060800.0 True False 933950.1887945738 872584.4777574879 951038.5919121221 1.0 0.9342944497754329 1.0182969106089093 19.832986081871358 -6.698054529400471 1.8379154104607576 0.9591212746257343 1.0180370696778311 0.4082733454065339 0.027745225768470185 0.3995977220553454 2.6228795482224894 0.012049847290620417 0.03106240883949628 2.0042203644939734e-07 6.698054529400471 0.058915795052096875 VYFPYLLISKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYFPYLLISKK 11 1 P28340;M0R2B7;A0A087WYJ2;M0QZR8;A0A2R8Y705;M0QXE6;M0QXQ2 P28340 POLD1 DNA polymerase delta catalytic subunit;DNA polymerase 1 3845100.0 712390.0 985010.0 2147700.0 True False 975779.8346158742 941489.001207517 1640457.4932699378 1.0 0.9648580220743584 1.6811758504065835 19.89619614339425 -6.895365106840448 0.9900912938430099 0.9663125047845895 1.7496750439696993 0.9841157707431002 0.041553557730505467 0.11489957680697212 0.19727960868486402 0.03173079006638838 0.08079748066832215 1.2724329101651902e-07 6.895365106840448 0.7833625391851098 VYGAAIQFYEPYSEENLTEK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYGAAIQFYEPYSEENLTEKQR 22 1 A0A0U1RR27;Q7Z401;Q7Z401-2;H3BTW5 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 22835900.0 7176200.0 7786900.0 7872800.0 True False 6948395.45905329 10896249.778147042 5810677.501062603 1.0 1.568167765113306 0.836261772276027 22.728248434854827 -6.699475249004325 1.8325690680644875 1.3529872770174305 0.8384484984691718 0.415158071362307 0.23985345268281993 0.39661944512678987 2.5891369498380232 0.10442684674265873 0.26874953425978904 1.997674615219255e-07 6.699475249004325 -0.5145387785482587 VYGAAIQFYEPYSEENLTEK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYGAAIQFYEPYSEENLTEKQR 22 1 A0A0U1RR27;Q7Z401;Q7Z401-2;H3BTW5 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 115762000.0 24788000.0 28720000.0 62254000.0 True False 37605208.24554065 23594691.609615818 49949469.61310253 1.0 0.6274314838401076 1.3282593540490686 25.164429150307495 -6.762269566541006 1.6037796288254524 0.7842030539828146 1.3311237753421938 0.700210102920032 0.15675932165622442 0.27912645748700043 1.415461220693672 0.07709967393014742 0.18488077099093683 1.7287429955286647e-07 6.762269566541006 0.5469207213593792 VYGAAIQFYEPYSEENLTEK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYGAAIQFYEPYSEENLTEKQR 22 1 A0A0U1RR27;Q7Z401;Q7Z401-2;H3BTW5 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 26028600.0 7176200.0 11433000.0 7419400.0 True False 5967328.259563373 11371408.159727192 8970762.236570371 1.0 1.9056112995800287 1.5033130148645044 22.508653710289103 -10.226935830002517 4.740889922533157 0.9998476489206678 1.704462157224586 0.8034761444236393 0.16423758699962285 0.0002645284427308519 4.3134728394241445e-05 0.15905629917953537 0.05300745327143967 5.930129398485277e-11 10.226935830002517 0.7046145083039181 VYGAAIQFYEPYSEENLTEK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYGAAIQFYEPYSEENLTEKQR 22 1 A0A0U1RR27;Q7Z401;Q7Z401-2;H3BTW5 A0A0U1RR27 DENND4A C-myc promoter-binding protein 1 126223000.0 24788000.0 31470000.0 69965000.0 True False 32088554.64452934 29718666.835646737 57232087.90152338 1.0 0.9261453862557616 1.7835670236795995 24.935555472399944 -6.885937701830006 1.0460781446426832 0.9493443241732009 1.851710521422083 0.9781696481959248 0.05732119437088717 0.12250259062348086 0.24157837323507025 0.041957421134416986 0.1031854880622893 1.300356096624968e-07 6.885937701830006 0.9023661972488821 VYGAGSSLYGGTITINAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYGAGSSLYGGTITINAR 18 0 Q5VTR2 Q5VTR2 RNF20 E3 ubiquitin-protein ligase BRE1A 0 7337400.0 2206500.0 1365700.0 3765200.0 False True 2136455.865277034 1911031.1320314158 2778981.1664212146 1.0 0.8944865948745505 1.3007435405462326 21.026788083579977 -6.837739722579905 1.2928917292808004 0.9438431017025645 1.3135154628645935 0.9204912888765578 0.04853288350456881 0.1714551830857031 0.557702841090728 0.029445794088571415 0.06780036715512476 1.4529821447513036e-07 6.837739722579905 0.36967236116202906 VYGAGSSLYGGTITINAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYGAGSSLYGGTITINAR 18 0 Q5VTR2 Q5VTR2 RNF20 E3 ubiquitin-protein ligase BRE1A 0 19023300.0 3952000.0 8142200.0 6929100.0 False True 5995472.92990062 6689160.794701043 5559560.347867577 1.0 1.1157019426008685 0.9272930447473027 22.51544212892056 -6.740523124543872 1.6846252289830403 1.06879886544832 0.9271661773996518 0.6073826719096174 0.048612450879998534 0.31685679430244845 1.7658116716804455 0.022825845960281314 0.055983802606875695 1.817510277948697e-07 6.740523124543872 -0.14163268804866824 VYGALMWSLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYGALMWSLGK 11 0 A0A024R571;Q9H4M9;C9JC03;C9J2Z4;Q9NZN3;C9JDQ8;Q9H223 A0A024R571;Q9H223 EHD1;EHD3;EHD4 EH domain-containing protein 1;EH domain-containing protein 3;EH domain-containing protein 4 0 8448400.0 4839500.0 1590400.0 2018500.0 False True 4685872.721508373 2225455.0138264345 1489794.2962979975 1.0 0.4749286090532278 0.31793315457753957 22.159886337323243 -13.999999999999998 0.16919315576510022 3.642403414842851 0.17824894979739292 0.9995152408648706 0.0064214330535540855 12.083789674809418 0.13023931197373687 10.478857532743556 0.12894301525413956 1.0000000000000041e-14 13.999999999999998 -3.464154465045458 VYGALMWSLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYGALMWSLGK 11 0 A0A024R571;Q9H4M9;C9JC03;C9J2Z4;Q9NZN3;C9JDQ8;Q9H223 A0A024R571;Q9H223 EHD1;EHD3;EHD4 EH domain-containing protein 1;EH domain-containing protein 3;EH domain-containing protein 4 0 43560000.0 11255000.0 12189000.0 20116000.0 False True 17074657.85071646 10013777.716908313 16140063.782843987 1.0 0.5864701831485385 0.9452642579404156 24.0253533336774 -10.170374237483527 7.621281264372031 1.0000001113399293 0.7658672205444771 0.36215144836821855 0.14647706766234722 2.772009385912059e-07 3.0225556827701226e-08 0.14182587854168724 0.047275270304797334 6.755006364037696e-11 10.170374237483527 -0.2341328907954522 VYGALMWSLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYGALMWSLGK 11 0 A0A024R571;Q9H4M9;C9JC03;C9J2Z4;Q9NZN3;C9JDQ8;Q9H223 A0A024R571;Q9H223 EHD1;EHD3;EHD4 EH domain-containing protein 1;EH domain-containing protein 3;EH domain-containing protein 4 0 9202700.0 4839500.0 1736800.0 2626400.0 False True 4024258.6762014623 1727443.5136721907 3175568.096898454 1.0 0.42925757329862846 0.7891063553339728 21.94029161275752 -10.130727951102353 5.49928898513166 1.0000064803191282 0.6091819643162137 0.611304377920755 0.1469076500917384 1.1672208010246002e-05 1.844913805217878e-06 0.14224507763772157 0.04741424018626977 7.400687205808057e-11 10.130727951102353 -0.39082451600291446 VYGALMWSLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYGALMWSLGK 11 0 A0A024R571;Q9H4M9;C9JC03;C9J2Z4;Q9NZN3;C9JDQ8;Q9H223 A0A024R571;Q9H223 EHD1;EHD3;EHD4 EH domain-containing protein 1;EH domain-containing protein 3;EH domain-containing protein 4 0 41094000.0 11255000.0 16301000.0 13538000.0 False True 14569819.369218063 15393835.020269386 11074222.91161042 1.0 1.05655633952417 0.7600796297452489 23.79647965576985 -6.857301941219871 1.1992240645424328 1.030493137044764 0.7464405792714138 0.950281760545503 0.028657083030687668 0.14960942655368828 0.4103776000442931 0.0186567641163378 0.043428560206784414 1.3889866089573858e-07 6.857301941219871 -0.28405255777335026 VYGESK(ub)LGGNEIVSFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYGESKLGGNEIVSFLK 17 1 Q5QPK2;H0Y368;O60762 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 1 24873400.0 3843200.0 8995200.0 12035000.0 True False 5038472.4176017465 7653151.223014967 10789733.647871798 1.0 1.5189427645329407 2.1414692298757454 22.264554967811232 -6.9687045287703056 0.287447423647216 0.8745884935451872 2.8049888516285697 0.9999704413701529 0.002537025595129621 0.07672531954625675 0.010527234672970558 0.01102750490473624 0.05662234011975783 1.0747203471295661e-07 6.9687045287703056 1.9304003580833826 VYGESK(ub)LGGNEIVSFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYGESKLGGNEIVSFLK 17 1 Q5QPK2;H0Y368;O60762 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 1 46308600.0 9354600.0 10302000.0 26652000.0 True False 9057643.34344915 14415642.324220285 19671041.657138545 1.0 1.5915444865298494 2.1717615621689754 23.110704301826843 -6.971362839248688 0.2232503058354476 0.7431722627110148 3.0365798639944446 0.9999911494222925 0.0014231563747528987 0.07586291143860491 0.007427807345251252 0.015678984579118198 0.05841008179239284 1.068162090818821e-07 6.971362839248688 2.29340760128343 VYGESK(ub)LGGNEIVSFLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYGESKLGGNEIVSFLK 17 1 Q5QPK2;H0Y368;O60762 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 1 88483000.0 17894000.0 34715000.0 35874000.0 True False 27146506.22662995 28519837.020466987 28783488.175867215 1.0 1.0505895964059582 1.0603017543241506 24.694263198379087 -13.999999998754012 0.23205392670392674 0.6775772516399639 1.0649325435438788 0.9995126193310025 0.0005835992538272209 13.355972840257362 0.152511335735119 1.9864134265882445 0.00497785207920902 1.0000000028689939e-14 13.999999998754012 0.38735529190391493 VYGESK(ub)LGGNEIVSFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYGESKLGGNEIVSFLK 17 1 Q5QPK2;H0Y368;O60762 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 1 34605800.0 3843200.0 7529600.0 23233000.0 True False 5264134.898574839 7196917.374942511 17745843.898654606 1.0 1.3671605142358594 3.3710845638585254 22.327765029334124 -6.937870778235583 0.6790809450997344 0.9764632480587498 3.879234305353564 0.9978715352129145 0.04807465316874422 0.08875152717488105 0.059134196987593285 0.04607404930207166 0.17415353677482026 1.1537965121064274e-07 6.937870778235583 2.902771057294814 up VYGESK(ub)LGGNEIVSFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYGESKLGGNEIVSFLK 17 1 Q5QPK2;H0Y368;O60762 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 1 41883600.0 9354600.0 13382000.0 19147000.0 True False 7778764.379046212 13309908.509880973 23150549.174274556 1.0 1.7110569058672218 2.9761216622829685 22.89110957726112 -6.962267184475754 0.40220808980025186 0.9321290079830709 3.8014071390273396 0.9998452622713645 0.010166041238354158 0.07890096901189171 0.01821033409260936 0.01627467983155552 0.10590576044603862 1.0907690724990386e-07 6.962267184475754 2.8692781310442688 VYGESK(ub)LGGNEIVSFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYGESKLGGNEIVSFLK 17 1 Q5QPK2;H0Y368;O60762 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 1 78980000.0 17894000.0 29014000.0 32072000.0 True False 23164135.743472926 27399345.394644193 26235225.086509753 1.0 1.182834779508864 1.1325794917214722 24.465389520471536 -10.11143724727703 4.3316658886474215 0.9999794473588312 1.157707135568139 0.9292305801187706 0.020516635397638983 4.424989979109578e-06 9.077061339265119e-07 0.019867958593015867 0.006621715590996752 7.736824627736238e-11 10.11143724727703 0.15772768820930783 VYGPSTEPLLLLEEIEK(ub)ENKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYGPSTEPLLLLEEIEKENKR 21 2 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 12594100.0 4473700.0 2877500.0 5242900.0 True False 4331684.842279571 4026500.7559642624 3869627.206371444 1.0 0.9295461010144256 0.8933307355608615 22.04649685081606 -13.999999973419762 0.08498897219127612 1.3694371618614098 0.794500001210668 0.9998652750109159 0.0005140348056028903 12.210163582108231 0.08344015426769875 0.8301846501929723 0.08923872356414085 1.0000000612032628e-14 13.999999973419762 -0.5749371606507419 VYGPSTEPLLLLEEIEK(ub)ENKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYGPSTEPLLLLEEIEKENKR 21 2 O75113 O75113 N4BP1 NEDD4-binding protein 1 1 10406600.0 4473700.0 3555000.0 2377900.0 True False 3720079.768513785 3535848.509387745 2875107.895832635 1.0 0.9504765299160124 0.7728618940290288 21.826902126250335 -6.947384087092476 0.5868634487610023 1.0020729764248653 0.7123761984792489 0.9989796539809904 0.003115060079748721 0.08455354764227806 0.04044346474576373 0.0032400296652189413 0.014865896978007023 1.1287971725386487e-07 6.947384087092476 -0.2896967779456163 VYGSGEK(ub)VAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYGSGEKVAGR 11 1 Q9H3M7 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 172651600.0 45481400.0 53982200.0 73188000.0 True False 59626555.8425041 45928266.18096754 65615207.82886923 1.0 0.7702652875386793 1.1004359869817635 25.829451670226632 -6.719588071221931 1.7607232410632045 0.8601703537297691 1.0999115705129592 0.5105822384045278 0.09667827678765772 0.3561309041670493 2.1574543470620005 0.043600946948024154 0.10951081629072268 1.9072689068801742e-07 6.719588071221931 0.23974121678319005 VYGSGEK(ub)VAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYGSGEKVAGR 11 1 Q9H3M7 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 157690200.0 49853400.0 43252300.0 64584500.0 True False 48270831.105371445 60523168.94776483 47667881.956531 1.0 1.2538248785409867 0.9875090373413242 25.524648330879604 -6.6570347566421635 1.9832414106502811 1.1637785815024084 0.9886197591051681 0.2231662674004552 0.10814937187958422 0.4914993147970596 3.7130169905635437 0.04410363093781743 0.119866448726271 2.2027501696252537e-07 6.6570347566421635 -0.17515882239724034 VYGSGEK(ub)VAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYGSGEKVAGR 11 1 Q9H3M7 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 340046000.0 99903000.0 144033000.0 96110000.0 True False 151560154.88761666 118329185.81503446 77113816.37349045 1.0 0.7807407290047751 0.5088000631212808 27.175315278427927 -6.968224058243865 0.2975639361559619 1.048550041121527 0.2324991124987306 0.9999650261758656 0.0011881741749069834 0.07688327409968658 0.01108180806829459 0.004567000343290244 0.02445285615133268 1.0759099942814183e-07 6.968224058243865 -0.8160509286227964 VYGSGEK(ub)VAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYGSGEKVAGR 11 1 Q9H3M7 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 155921500.0 45481400.0 44213200.0 66226900.0 True False 62297102.66862026 42259714.63049945 50585470.20581965 1.0 0.6783576253183623 0.8120035770347328 25.892661731749524 -10.09280531789714 5.055269168714542 1.0000066087477093 0.7451806015365793 0.8289783476750028 0.05456073131836248 4.0640132987415605e-06 7.292699593264779e-07 0.05282957037345407 0.017609400312350493 8.075969723156389e-11 10.09280531789714 -0.25482600721113 VYGSGEK(ub)VAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYGSGEKVAGR 11 1 Q9H3M7 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 158529200.0 49853400.0 65499900.0 43175900.0 True False 41455310.980089195 65147039.03798773 52203781.067193925 1.0 1.5715004301687079 1.2592784816465898 25.30505360631388 -10.081438072698935 4.632662084583416 0.99997861799901 1.4153894558650832 0.7023861553965833 0.12746407677180024 3.0374563362087836e-05 6.022776239247433e-06 0.12342340839855005 0.041138853875391644 8.290141193565196e-11 10.081438072698935 0.41541083786607325 VYGSGEK(ub)VAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYGSGEKVAGR 11 1 Q9H3M7 Q9H3M7 TXNIP Thioredoxin-interacting protein 1 300704000.0 99903000.0 135361000.0 65440000.0 True False 129326402.88254032 127828041.35811813 53530591.47110259 1.0 0.9884141096402174 0.4139185060278938 26.946441600520377 -6.911259775495824 0.8870995483785201 1.017086932088607 0.33763550820658855 0.9913885543213944 0.025388712463892606 0.10359140793223012 0.13428784043522135 0.020916370913054073 0.058256221140684454 1.226705251557723e-07 6.911259775495824 -0.6794514238820184 down VYIASSSGSTAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYIASSSGSTAIK 13 0 O75368 O75368 SH3BGRL SH3 domain-binding glutamic acid-rich-like protein 0 6158700.0 1777900.0 2111600.0 2269200.0 False True 2330844.1172080925 1796557.5109523349 2034404.951703422 1.0 0.7707754875964287 0.8728189657488772 21.152421092087458 -10.139995151159393 4.752060112380625 1.0000142303281454 0.8217972266726314 0.8026164638972307 0.041659075514173305 6.440899135339088e-06 1.1656719328114768e-06 0.040339528401342126 0.013445408806288155 7.244440483520829e-11 10.139995151159393 -0.17821700365551396 VYIASSSGSTAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYIASSSGSTAIK 13 0 O75368 O75368 SH3BGRL SH3 domain-binding glutamic acid-rich-like protein 0 4872360.0 1458800.0 373460.0 3040100.0 False True 1412491.1925067478 522584.52556817123 2243806.6089549344 1.0 0.36997365246627884 1.588545557564045 20.42981044105274 -6.766164433752761 1.5889599775722967 0.6368701223365574 1.5944577685698442 0.7157506058307193 0.2652828452754043 0.2726708648318329 1.3580071813072954 0.13164011865396935 0.31449599871108097 1.7133084871882497e-07 6.766164433752761 0.9575876462332868 VYIASSSGSTAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYIASSSGSTAIK 13 0 O75368 O75368 SH3BGRL SH3 domain-binding glutamic acid-rich-like protein 0 5819100.0 1777900.0 1737400.0 2303800.0 False True 2435237.6759409355 1660635.9231865052 1759689.8882503547 1.0 0.6819194444931799 0.722594720685914 21.21563115361035 -10.601418240209464 9.822878691980987 1.0000361927150845 0.7022570826778948 0.9861960707107946 0.01660561196982918 1.3163446945429015e-05 5.341364989979329e-07 0.016080258339138044 0.0053594382177275844 2.5036969471890455e-11 10.601418240209464 -0.2977791100371897 VYIGSFWAQPLQNTDNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYIGSFWAQPLQNTDNR 17 0 Q9H223 Q9H223 EHD4 EH domain-containing protein 4 0 3109770.0 1105800.0 818070.0 1185900.0 False True 1449714.5085824323 696017.1448118847 1063194.4439560578 1.0 0.48010635245174443 0.7333819435908635 20.467337388457466 -10.071817999421636 5.26576044146046 1.000005094377377 0.6067441480207407 0.7627193528512164 0.10339932710074626 6.184197243045435e-06 1.089922987749408e-06 0.10011726548842369 0.03337198932223531 8.475825376797924e-11 10.071817999421636 -0.39326094635663633 VYIGSFWAQPLQNTDNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYIGSFWAQPLQNTDNR 17 0 Q9H223 Q9H223 EHD4 EH domain-containing protein 4 0 1933600.0 1105800.0 827800.0 0.0 False True 1514644.14312137 791225.0588314674 0.0 1.0 0.522383467050495 0.0 20.530547449980357 -7.861169014951366 0.6070257032881167 1.0072603435298126 6.2208241927958895e-18 0.9884862975844834 0.04382045502555749 0.11452800730714198 0.15853643133178338 0.04396413875027556 0.07755427757808533 1.3766736027628495e-08 7.861169014951366 -1.0072603435298126 down VYIGSFWSHPLLIPDNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYIGSFWSHPLLIPDNR 17 0 A0A024R571;Q9H4M9;C9JC03;C9J2Z4;Q9NZN3;C9JDQ8 A0A024R571 EHD1;EHD3 EH domain-containing protein 1;EH domain-containing protein 3 0 11839100.0 3296800.0 5515800.0 3026500.0 False True 4322136.726256619 4692864.140420007 2713346.812237968 1.0 1.085774106106188 0.6277790324759078 22.043313280386098 -6.858289034423591 1.1943263963539588 1.0463446080941268 0.6063128607001289 0.9515227001552344 0.043769199001770336 0.148582878698291 0.4037015339049819 0.028601828652802596 0.06664292397076928 1.385833213366175e-07 6.858289034423591 -0.44003174739399786 VYIGSFWSHPLLIPDNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYIGSFWSHPLLIPDNR 17 0 A0A024R571;Q9H4M9;C9JC03;C9J2Z4;Q9NZN3;C9JDQ8 A0A024R571 EHD1;EHD3 EH domain-containing protein 1;EH domain-containing protein 3 0 31358900.0 14457000.0 8727000.0 8174900.0 False True 13998070.448361704 12211736.610703774 6033648.448256873 1.0 0.872387137623886 0.4310342965135623 23.738724638065136 -6.948218023330663 0.5780825403038805 1.0053144478972853 0.2763490040635264 0.9990538688070311 0.007498074140332329 0.08420941988417825 0.038986303941726225 0.007872414369923565 0.03684959628434708 1.1266317255996997e-07 6.948218023330663 -0.7289654438337589 down VYIGSFWSHPLLIPDNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYIGSFWSHPLLIPDNR 17 0 A0A024R571;Q9H4M9;C9JC03;C9J2Z4;Q9NZN3;C9JDQ8 A0A024R571 EHD1;EHD3 EH domain-containing protein 1;EH domain-containing protein 3 0 43959000.0 14080000.0 15031000.0 14848000.0 False True 21360389.385880753 12348600.612260979 11913286.291890403 1.0 0.5781074674801303 0.5577279550795596 24.348434610860544 VYIGSFWSHPLLIPDNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYIGSFWSHPLLIPDNR 17 0 A0A024R571;Q9H4M9;C9JC03;C9J2Z4;Q9NZN3;C9JDQ8 A0A024R571 EHD1;EHD3 EH domain-containing protein 1;EH domain-containing protein 3 0 36053120.0 3296800.0 13576000.0 19180320.0 False True 4515716.052670049 12976167.430171542 14650323.447090054 1.0 2.8735569904797282 3.244296868140685 22.10652334190899 -10.06158642389883 0.3820741182505052 1.0917491615992851e-22 3.295338365015221 0.9989138407799015 0.032374174403545765 1.4140844600211524 0.17235407833264516 1.6632885430168494 0.09906435327307382 8.677878717272488e-11 10.06158642389883 3.295338365015221 VYIGSFWSHPLLIPDNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYIGSFWSHPLLIPDNR 17 0 A0A024R571;Q9H4M9;C9JC03;C9J2Z4;Q9NZN3;C9JDQ8 A0A024R571 EHD1;EHD3 EH domain-containing protein 1;EH domain-containing protein 3 0 32952000.0 14457000.0 8633100.0 9861900.0 False True 12021636.053692421 8586591.776763823 11923977.693726337 1.0 0.7142614980534591 0.9918764501329177 23.519129913499413 -10.731084944732851 9.265171928496576 1.0004737718902277 0.8530689741472689 0.2719282060811056 0.11333582959364624 0.0011126179536920804 3.229282583151306e-05 0.11007959467900155 0.03657898171206613 1.857441118053316e-11 10.731084944732851 -0.14740479774295878 VYIGSFWSHPLLIPDNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYIGSFWSHPLLIPDNR 17 0 A0A024R571;Q9H4M9;C9JC03;C9J2Z4;Q9NZN3;C9JDQ8 A0A024R571 EHD1;EHD3 EH domain-containing protein 1;EH domain-containing protein 3 0 45066000.0 14080000.0 19681000.0 11305000.0 False True 18226837.558293242 18585735.049010556 9247605.99909556 1.0 1.0196906067533376 0.5073620681327619 24.119560932952993 -6.897962199495837 0.9740726099383259 1.0225080359934167 0.4557579076663915 0.9855245612972365 0.028515508538153933 0.11292044757232159 0.18600540003269878 0.02203772595795579 0.056773352127849924 1.2648464334938453e-07 6.897962199495837 -0.5667501283270251 VYIGSFWSHPLLIPDNRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYIGSFWSHPLLIPDNRK 18 1 A0A024R571;Q9H4M9;C9JC03;C9J2Z4;Q9NZN3;C9JDQ8 A0A024R571 EHD1;EHD3 EH domain-containing protein 1;EH domain-containing protein 3 0 14229800.0 2619400.0 4499900.0 7110500.0 False True 3390864.936093271 4249476.60926999 5816461.959891111 1.0 1.2532131740304449 1.715332833808607 21.693221889839357 -6.961795086699979 0.4093498440529947 0.977073618132355 2.0086039750224796 0.9998310901690487 0.003848989547090264 0.0790660106022008 0.018807125310771656 0.0059496158186500055 0.03859168970729758 1.0919554325904625e-07 6.961795086699979 1.0315303568901246 VYIPCIYVLNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYIPCIYVLNK 11 0 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 0 29854200.0 8678800.0 11663000.0 9512400.0 False True 11377990.845618747 9922925.862017928 8528148.097383933 1.0 0.8721158240199224 0.7495302301695747 23.439742489609287 -6.971640521689267 0.21543368236050628 1.0598942575540944 0.558308531197016 0.9999925033327397 0.00027993284014631503 0.07577388508576668 0.007093716847746873 0.003517353753773721 0.012547886500933927 1.0674793396797565e-07 6.971640521689267 -0.5015857263570784 VYIPCIYVLNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYIPCIYVLNK 11 0 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 0 7928900.0 4941000.0 1265300.0 1722600.0 False True 4784150.6595666595 1770540.8884523301 1271399.3831077176 1.0 0.3700846847103061 0.2657523714403423 22.189831392051502 -13.999999999999998 0.2530040156992521 5.447957527867726 0.22498463039843541 0.9995484161053136 0.006892495765315126 14.119090200110984 0.1591621448986265 31.97402021098491 0.04735778865355928 1.0000000000000041e-14 13.999999999999998 -5.22297289746929 VYIPCIYVLNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYIPCIYVLNK 11 0 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 0 14600300.0 3961100.0 5211500.0 5427700.0 False True 6009278.295199736 4281467.10736465 4354912.7159545785 1.0 0.7124760906454812 0.7246981254692965 22.5187603052761 -10.07262805021421 14.12188119851779 0.9999999268816387 0.7185871080577403 0.9985873097665522 0.0049896248229909495 0.0 0.0 0.004831183460736064 0.001610394486912021 8.460030909677028e-11 10.07262805021421 -0.28141281882389846 VYIPCIYVLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYIPCIYVLNK 11 0 Q9Y295 Q9Y295 DRG1 Developmentally-regulated GTP-binding protein 1 0 34800800.0 8678800.0 10395000.0 15727000.0 False True 11887586.895751262 9935714.528331839 12012606.507732157 1.0 0.8358058380951107 1.0105168200306134 23.50295255113218 -13.488449843377559 11.738596409636331 8.740444883899107 0.9308451961565798 0.0 0.08198055486126683 0.0 0.0 0.0 0.023780224618563675 3.247507454303767e-14 13.488449843377559 -7.809599687742527 VYIYSSGSVEAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYIYSSGSVEAQK 13 0 A0A0C4DGY8;D6RA00;Q9UHY7;Q9UHY7-2 A0A0C4DGY8 ENOPH1 Enolase-phosphatase E1 0 3590200.0 0.0 1815900.0 1774300.0 False True 0.0 1544974.7983227614 1590712.4562874069 0.0 VYIYSSGSVEAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYIYSSGSVEAQK 13 0 A0A0C4DGY8;D6RA00;Q9UHY7;Q9UHY7-2 A0A0C4DGY8 ENOPH1 Enolase-phosphatase E1 0 1996600.0 0.0 0.0 1996600.0 False True 0.0 0.0 1473630.563283914 0.0 VYIYSSGSVEAQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYIYSSGSVEAQK 13 0 A0A0C4DGY8;D6RA00;Q9UHY7;Q9UHY7-2 A0A0C4DGY8 ENOPH1 Enolase-phosphatase E1 0 2555800.0 0.0 1083300.0 1472500.0 False True 0.0 1035436.2240059536 1124725.8270894368 0.0 VYK(ub)NELHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYKNELHR 8 1 O95140;O95140-2 O95140 MFN2 Mitofusin-2 1 5585380.0 933580.0 1331200.0 3320600.0 True False 903944.0139158549 1862755.102116293 2450835.2441353123 1.0 2.0606974253271515 2.7112688467490114 19.7858738960295 -8.656771566851877 0.17724417373093376 4.968693167331631e-13 3.6125382356064026 0.9997766555095232 0.010540188229477075 0.23904044512705538 0.049549682094345536 0.500470700152462 0.37540382461463645 2.20408547799637e-09 8.656771566851877 3.6125382356059057 VYK(ub)NELHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYKNELHR 8 1 O95140;O95140-2 O95140 MFN2 Mitofusin-2 1 7913350.0 492950.0 1856400.0 5564000.0 True False 747841.1894722945 1525110.9158805984 4464272.961212167 1.0 2.0393513186359464 5.969546775515707 19.512372408338052 -6.946167007162981 0.5994503258506454 0.9556780947528506 7.254218220086224 0.9988651200157965 0.07209812070553971 0.08506238366612663 0.042620687609556854 0.07403745435173974 0.33022454198486123 1.1319649844272092e-07 6.946167007162981 6.298540125333373 VYK(ub)NELHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYKNELHR 8 1 O95140;O95140-2 O95140 MFN2 Mitofusin-2 1 4810540.0 851140.0 1111100.0 2848300.0 True False 1165829.4591936367 1062007.928083648 2175590.202579859 1.0 0.9109462106217504 1.8661307495906294 20.152925331815993 -6.884083356391172 1.0568036567864518 0.9411635458872217 1.9393449603083492 0.9768310610990311 0.06557734478369298 0.12407277055115629 0.25097112389363624 0.0476124573790757 0.11642748131159793 1.3059202120400104e-07 6.884083356391172 0.9981814144211275 VYK(ub)NELHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYKNELHR 8 1 O95140;O95140-2 O95140 MFN2 Mitofusin-2 1 4780180.0 933580.0 1688600.0 2158000.0 True False 776313.1346064997 1679503.1766391422 2609227.8225353574 1.0 2.1634352193338255 3.3610507232470463 19.566279171463776 -6.970762574303609 0.2392723243699476 0.5660708508537072 4.9930231812276045 0.9999877346813579 0.0033758539051334277 0.07605603097227089 0.008139598033180762 0.02877557865442456 0.11690710434982836 1.0696394836869026e-07 6.970762574303609 4.426952330373897 VYK(ub)NELHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYKNELHR 8 1 O95140;O95140-2 O95140 MFN2 Mitofusin-2 1 2650550.0 492950.0 1115200.0 1042400.0 True False 638133.4924972048 1053138.1396604136 852693.8959272192 1.0 1.6503414286236147 1.3362312211358414 19.2834987304305 -10.029641472885404 4.45900915582073 0.9999775112370567 1.4932863248665507 0.7668079170938533 0.12823495540428162 59093859.617029816 60401421.54953054 16900.738627415834 0.04692918994667839 9.340250568969817e-11 10.029641472885404 0.49330881362949397 VYLGDIPLK(ub)TK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYLGDIPLKTK 11 1 Q5VYK3;J3KN16;R4GMY1 Q5VYK3 ECM29;KIAA0368 Proteasome-associated protein ECM29 homolog 1 7895900.0 1776300.0 1868700.0 4250900.0 True False 2433046.1127025587 1786134.655035468 3246924.970033612 1.0 0.7341145922842705 1.334510247496715 21.214332232772268 -6.7863108773609335 1.510889232880054 0.8506788727509841 1.3402754141658806 0.7891849668467323 0.11278628174118514 0.2409024287441477 1.086408127689809 0.05876862211617491 0.13797942526905957 1.6356452720969074e-07 6.7863108773609335 0.4895965414148965 VYLHLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYLHLR 6 0 P45974-2;P45974;F5H571;Q8IWA5-3;Q8IWA5;Q8IWA5-2 P45974-2 USP5;SLC44A2 Ubiquitin carboxyl-terminal hydrolase 5;Choline transporter-like protein 2 0 43750000.0 16625000.0 12608000.0 14517000.0 False True 21795535.99672903 10726935.545599071 13014920.096896965 1.0 0.49216204397124796 0.5971369595521845 24.377529347156237 -10.309136014305084 5.61198658018548 1.0000604263552568 0.5446495017617784 0.9616676271566146 0.042855829827526115 3.240502098268147e-05 3.989207285621842e-06 0.04150045972417636 0.013831659600822669 4.9075415548203007e-11 10.309136014305084 -0.45541092459347843 VYLHLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYLHLR 6 0 P45974-2;P45974;F5H571;Q8IWA5-3;Q8IWA5;Q8IWA5-2 P45974-2 USP5;SLC44A2 Ubiquitin carboxyl-terminal hydrolase 5;Choline transporter-like protein 2 0 40151300.0 13664000.0 4436300.0 22051000.0 False True 13230243.79929547 6207737.7249988755 16275181.584179899 1.0 0.46920811280359376 1.2301497864345157 23.657336311224483 -6.719149804376372 1.7622868816581119 0.6767773119045317 1.2289127212399549 0.5085026187603663 0.22338342674942666 0.35699200773712453 2.1662726979221367 0.10066325678420993 0.2529638383850811 1.9091945924999716e-07 6.719149804376372 0.5521354093354232 VYLHLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYLHLR 6 0 P45974-2;P45974;F5H571;Q8IWA5-3;Q8IWA5;Q8IWA5-2 P45974-2 USP5;SLC44A2 Ubiquitin carboxyl-terminal hydrolase 5;Choline transporter-like protein 2 0 26921300.0 9533100.0 9369500.0 8018700.0 False True 14462409.662964476 7697439.5207623625 6433800.430278943 1.0 0.5322376906853955 0.44486365551894863 23.785804612017927 -13.99999999999998 0.2359352316173052 4.036279533510995 0.40471163730354004 0.9995184486219822 0.005348342661041433 13.48340079668938 0.15375742406997886 19.24312439164365 0.043738246813463985 1.000000000000045e-14 13.99999999999998 -3.631567896207455 VYLHLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYLHLR 6 0 P45974-2;P45974;F5H571;Q8IWA5-3;Q8IWA5;Q8IWA5-2 P45974-2 USP5;SLC44A2 Ubiquitin carboxyl-terminal hydrolase 5;Choline transporter-like protein 2 0 42350000.0 16625000.0 10895000.0 14830000.0 False True 22771711.773731966 10413622.87505296 11327459.433437252 1.0 0.45730522933570017 0.497435570324753 24.44073940867913 -10.045970813663876 6.353513801063754 1.000000453686943 0.4773704014726172 0.9955974652455482 0.01638314310453413 1.0528253512708907e-07 1.581170440776867e-08 0.0158629239278642 0.005287636700196341 8.99558033417005e-11 10.045970813663876 -0.5226300522143257 VYLHLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYLHLR 6 0 P45974-2;P45974;F5H571;Q8IWA5-3;Q8IWA5;Q8IWA5-2 P45974-2 USP5;SLC44A2 Ubiquitin carboxyl-terminal hydrolase 5;Choline transporter-like protein 2 0 28693900.0 13664000.0 8318600.0 6711300.0 False True 11362221.417835893 8273786.050687182 8114601.800454851 1.0 0.728183842439417 0.7141738839657641 23.43774158665876 VYLHLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYLHLR 6 0 P45974-2;P45974;F5H571;Q8IWA5-3;Q8IWA5;Q8IWA5-2 P45974-2 USP5;SLC44A2 Ubiquitin carboxyl-terminal hydrolase 5;Choline transporter-like protein 2 0 31032200.0 9533100.0 12804000.0 8695100.0 False True 12340785.875494694 12091446.144379409 7112681.019260147 1.0 0.9797954738352277 0.5763555976920333 23.556930934110376 -6.917304708685494 0.8444719119163996 1.0097954302432233 0.5151656481429164 0.9933989396258058 0.01585290080042913 0.09978386066999682 0.11402243121621727 0.013467413852492062 0.03935820659353551 1.2097490543996337e-07 6.917304708685494 -0.49462978210030684 VYLHYLPSYYHLHVHFTALGFEAPGSGVER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYLHYLPSYYHLHVHFTALGFEAPGSGVER 30 0 Q96C86;A0A3B3ITF0 Q96C86 DCPS m7GpppX diphosphatase 0 73430400.0 6768400.0 29954000.0 36708000.0 False True 10268157.63632068 24608474.66832977 29452647.710312054 1.0 2.396581308927739 2.868347833513162 23.291674013600616 -9.8688268862378 0.2781307833711851 1.2682359001057163e-24 3.0771804393792443 0.9989379925844025 0.025851970448540998 1.27732831587123 0.1217809373877353 1.2268512442213344 0.1837513252790369 1.3526116191432683e-10 9.8688268862378 3.0771804393792443 VYLHYLPSYYHLHVHFTALGFEAPGSGVER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYLHYLPSYYHLHVHFTALGFEAPGSGVER 30 0 Q96C86;A0A3B3ITF0 Q96C86 DCPS m7GpppX diphosphatase 0 59965900.0 6768400.0 26479500.0 26718000.0 False True 8761827.22511022 25005892.547648758 21855598.149830654 1.0 2.8539586441496163 2.4944109930854887 23.062800335693066 -9.899668003339254 5.442978187132924 0.999998283197493 2.6741848186264456 0.966565214721079 0.1467847139184795 3.0578812999740498e-06 6.182651633552403e-07 0.14212383416787266 0.04737456270248161 1.259888165974777e-10 9.899668003339254 1.6741865354289527 VYLK(ub)SQLNCLLLSGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYLKSQLNCLLLSGR 15 1 Q6RFH5;E9PS41 Q6RFH5 WDR74 WD repeat-containing protein 74 1 51124000.0 3878000.0 10707000.0 36539000.0 True False 5883209.519775962 8796252.195827175 29317050.634387385 1.0 1.49514515270266 4.983172966361361 22.488171985442676 -6.932541727012851 0.7256245295078408 0.9516377601619642 5.747914428950718 0.997014651922356 0.09684879718266712 0.09133934932683849 0.07137082044908283 0.0896076937211955 0.3113127514571924 1.1680414990452231e-07 6.932541727012851 4.796276668788754 up VYLK(ub)SQLNCLLLSGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYLKSQLNCLLLSGR 15 1 Q6RFH5;E9PS41 Q6RFH5 WDR74 WD repeat-containing protein 74 1 78608000.0 3878000.0 5732000.0 68998000.0 True False 5020147.446808322 5413009.161167049 56441071.9792655 1.0 1.0782570070941835 11.242911204759384 22.259298307535126 -6.90858589390663 0.9052941852068086 0.6710361188421576 12.51762345730033 0.9903773419387147 0.4718587907687971 0.10536088470449313 0.14388801959750966 0.3836365256466291 1.0489383799889254 1.2342811773304692e-07 6.90858589390663 11.846587338458171 up VYLLYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYLLYR 6 0 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5H3F0;Q96FW1-2 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 7763200.0 1536700.0 2656400.0 3570100.0 False True 2014628.5814239667 2260075.474566101 3200700.298817376 1.0 1.1218323294950225 1.588729718385648 20.942082456152356 -6.94586020599494 0.6025908950842674 0.9947696009520621 1.7397993042269808 0.9988349792874355 0.00866062675156757 0.08519207749938004 0.04318061253242098 0.008866217782940439 0.03927024578819006 1.132764927533033e-07 6.94586020599494 0.7450297032749187 VYLLYRPGHYDILYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYLLYRPGHYDILYK 15 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5H3F0;Q96FW1-2 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 49246500.0 17879000.0 22891000.0 8476500.0 False True 23439542.140482306 19475752.028419152 7599433.092329479 1.0 0.8308930230673186 0.32421422938993927 24.482441053165083 -6.9514790146206185 0.5423622223274213 1.0073458969164037 0.12426794933783702 0.999312305401789 0.007529747600740179 0.08289720469362646 0.03354595577367884 0.008255259989469844 0.041976335844796216 1.118203855584331e-07 6.9514790146206185 -0.8830779475785667 down VYLLYRPGHYDILYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYLLYRPGHYDILYK 15 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5H3F0;Q96FW1-2 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 66997000.0 29971000.0 13053000.0 23973000.0 False True 29019587.010295995 18265130.970495775 17693752.125415813 1.0 0.6294069920435258 0.6097175717606926 24.790523652174514 VYLLYRPGHYDILYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYLLYRPGHYDILYK 15 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5H3F0;Q96FW1-2 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 98464000.0 22650000.0 31122000.0 44692000.0 False True 34361705.93680391 25568035.942704167 35858606.610800505 1.0 0.7440851740518193 1.0435630488413354 25.034298327156844 -6.680427741741205 1.9002697222861955 0.8381404559147954 1.0424287998747896 0.3260736221002485 0.10845297211462146 0.43760453015624545 3.055507303949989 0.04578813924484983 0.12070133889508003 2.0872393715604784e-07 6.680427741741205 0.2042883439599943 VYLLYRPGHYDILYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYLLYRPGHYDILYK 15 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5H3F0;Q96FW1-2 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 75778000.0 17879000.0 27068000.0 30831000.0 False True 24489349.461807746 25872046.258093923 23549352.784376554 1.0 1.0564611484858981 0.961616102587896 24.545651114687974 -6.7455017411134675 1.6670538784142004 1.0333794992388674 0.9614967469804364 0.6291592944356066 0.02372173205187917 0.3079561230862945 1.6824676568572992 0.01124920790430145 0.02743426263280553 1.7967938767011538e-07 6.7455017411134675 -0.07188275225843099 VYLLYRPGHYDILYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYLLYRPGHYDILYK 15 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5H3F0;Q96FW1-2 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 66389000.0 29971000.0 16685000.0 19733000.0 False True 24922214.440424435 16595114.593286792 23859079.064916708 1.0 0.6658764064869418 0.9573418574802367 24.57092892760879 -10.187319370650897 7.362853116733099 1.0000001956194493 0.811609132941673 0.3577546211559287 0.1189902720972915 3.82125031661702e-07 4.220370251720151e-08 0.1152119557225101 0.038403945182791596 6.496517749525137e-11 10.187319370650897 -0.18839106267777628 VYLLYRPGHYDILYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYLLYRPGHYDILYK 15 1 J3KR44;Q96FW1;F5H6Q1;F5GYN4;F5H3F0;Q96FW1-2 J3KR44 OTUB1 Ubiquitin thioesterase OTUB1 0 124726000.0 22650000.0 58420000.0 43656000.0 False True 29320871.49824871 55168875.64469268 35711055.94838708 1.0 1.88155647583626 1.2179397856751988 24.805424649249293 -10.181973277019102 4.722254803949653 0.9999246269942225 1.5497481307589507 0.4778128580772881 0.27092037929269136 33654189.304307185 72564108.33368741 17280.56654312845 0.09274325473441163 6.576983055613669e-11 10.181973277019102 0.5498235037647282 VYMFQYDSTHGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYMFQYDSTHGK 12 0 P04406-2 P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 12860080.0 3058600.0 394780.0 9406700.0 False True 4009854.2195245335 335880.3628403873 8433384.919437937 1.0 0.08376373415395987 2.103164967537878 21.93511835697892 -6.783324799342383 1.5226820505034164 0.4834527446071638 2.1209321464238835 0.7790684969609227 0.38805666141822354 0.24543383961293158 1.1241241578525747 0.20067518507873153 0.47225727300760156 1.646930227739713e-07 6.783324799342383 1.6374794018167198 VYMGHGGKPWVSDFSHPHYLAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYMGHGGKPWVSDFSHPHYLAGR 23 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 40733000.0 13100700.0 11119400.0 16512900.0 False True 12684825.449460628 15559434.406904956 12187676.11361862 1.0 1.22661793565055 0.9608075540477266 23.596600331431272 -6.680916422125711 1.8988111239416685 1.1432666182026852 0.9618161347465563 0.3282664452712869 0.09602696104184237 0.43647708180415407 3.043453325519829 0.04056960773199225 0.10686712542222733 2.084892071896502e-07 6.680916422125711 -0.1814504834561289 VYMGHGGKPWVSDFSHPHYLAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYMGHGGKPWVSDFSHPHYLAGR 23 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 49736790.0 10093700.0 19212690.0 20430400.0 False True 13825613.661986064 18363809.82793033 15605160.297295777 1.0 1.328245550388998 1.128713753965412 23.72084018137718 -10.258176455496585 4.268322264389528 0.9998497066956806 1.228479652107781 0.6361352972545933 0.08145851486602307 0.00012083307803629581 2.100031141125899e-05 0.07892545336469597 0.026290622611338473 5.518531736845508e-11 10.258176455496585 0.22862994541210035 VYMGHGGKPWVSDFSHPHYLAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYMGHGGKPWVSDFSHPHYLAGR 23 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 38737400.0 13100700.0 17805600.0 7831100.0 False True 10893812.509414706 17709677.698665116 9468546.803084644 1.0 1.625663897130593 0.8691674099312511 23.37700560686555 -6.687072355277104 1.876900062428533 1.39332105032882 0.8718747444515196 0.35675630848167916 0.26477068278823174 0.42297223143374607 2.886576220748993 0.11295220768915555 0.29521661961898127 2.0555481045432165e-07 6.687072355277104 -0.5214463058773005 VYMGHGGKPWVSDFSHPHYLAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYMGHGGKPWVSDFSHPHYLAGR 23 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 84101500.0 12530700.0 20582800.0 50988000.0 False True 16221238.167024529 19437349.086264677 41708707.181060106 1.0 1.1982654397971941 2.571240663110907 23.951380608874633 -6.93288296389762 0.7227411268511212 0.9811904691191664 2.874974740564899 0.9970750690760944 0.03778552161709993 0.09116826941141168 0.07054892137612181 0.03503490004014147 0.12232085667176588 1.1671240978049403e-07 6.93288296389762 1.8937842714457327 up VYMPCLYVYNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYMPCLYVYNK 11 0 P55039;A8MZF9 P55039 DRG2 Developmentally-regulated GTP-binding protein 2 0 16106100.0 4596900.0 6279800.0 5229400.0 False True 6026580.416442917 5342878.318468674 4688311.851946879 1.0 0.8865522318247293 0.7779389849599108 22.5229081940653 -6.971655291704684 0.21501011862679426 1.0533534470426675 0.6080884486724673 0.9999925708149245 0.0002470489586576996 0.07576918584557105 0.007075852146608868 0.003126746331610252 0.011128085442175249 1.0674430361602368e-07 6.971655291704684 -0.4452649983702003 VYMPCLYVYNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYMPCLYVYNK 11 0 P55039;A8MZF9 P55039 DRG2 Developmentally-regulated GTP-binding protein 2 0 12760200.0 4596900.0 3871000.0 4292300.0 False True 6296498.156551475 3699966.4203148163 3278547.1426933724 1.0 0.5876228862967299 0.5206937350219122 22.586118255588193 -13.999999999999998 0.25589183480921657 3.955244284347054 0.49525160752484526 0.9995540690799097 0.004475559537850831 14.23954227379412 0.1600711082018449 21.706949315349288 0.02990800566925597 1.0000000000000041e-14 13.999999999999998 -3.4599926768222087 VYNALVAFIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYNALVAFIR 10 0 Q9BW92 Q9BW92 TARS2 Threonine--tRNA ligase, mitochondrial 0 2111720.0 726920.0 0.0 1384800.0 False True 952999.1595032947 0.0 1241514.1799395797 1.0 0.0 1.3027442548707593 19.862115416189067 -6.7016744184080705 1.825274507088431 0.3800386777656222 1.2989397790398576 0.42532213689422527 0.42198732407361794 0.3920688878402641 2.540729169808105 0.1843740421199886 0.4731176204605683 1.9875844098958462e-07 6.7016744184080705 0.9189011012742354 VYNALVAFIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYNALVAFIR 10 0 Q9BW92 Q9BW92 TARS2 Threonine--tRNA ligase, mitochondrial 0 3291420.0 726920.0 1275000.0 1289500.0 False True 995681.9682743608 1218666.2841388248 984946.6580861334 1.0 1.223951344876641 0.989218133369601 19.925325477711958 -6.65687739412591 1.984590004777463 1.144527877172997 0.9902129530853288 0.2222203210442104 0.0954257995679604 0.49185191761139524 3.7208251938479173 0.038898188552962634 0.10571078135516782 2.2035484600261586e-07 6.65687739412591 -0.15431492408766823 VYNVTQHAVGIVVNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYNVTQHAVGIVVNK 15 0 P46778;G3V1B3;M0R181 P46778 RPL21 60S ribosomal protein L21 0 466884400.0 155584000.0 219928000.0 91372400.0 False True 203972130.67759913 187115599.67262962 81918060.55395103 1.0 0.9173586560626111 0.40161398658639164 27.603796805021688 -6.935007944587726 0.7044722680459928 1.0065787193095346 0.2808324065433077 0.9974342049125564 0.013411143677097791 0.09011956355014726 0.06554388235787807 0.01260522397283329 0.045449901463928695 1.1614273675515006e-07 6.935007944587726 -0.7257463127662269 down VYNVTQHAVGIVVNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYNVTQHAVGIVVNK 15 0 P46778;G3V1B3;M0R181 P46778 RPL21 60S ribosomal protein L21 0 420544400.0 136848000.0 88806400.0 194890000.0 False True 132503835.14680807 124267258.63925786 143842462.42532384 1.0 0.9378389576541353 1.0855720686571306 26.9814588762631 -6.792371936963446 1.4866249677887842 0.9653660345849046 1.0872527540704253 0.8090087520006489 0.026467874163832734 0.2318172888201455 1.0120182302220875 0.014011435056055881 0.0327515295811 1.612976585365347e-07 6.792371936963446 0.12188671948552077 VYNVTQHAVGIVVNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYNVTQHAVGIVVNK 15 0 P46778;G3V1B3;M0R181 P46778 RPL21 60S ribosomal protein L21 0 642484000.0 169350000.0 277172000.0 195962000.0 False True 256916331.14338824 227708491.0452794 157230024.80680415 1.0 0.8863138050893014 0.6119892188521565 27.936723358604766 -6.95621638962662 0.4858337263563317 1.006236361215534 0.4805159530554064 0.9996031062256506 0.003244662393200824 0.08108147437769805 0.02634403844472834 0.003914819810828237 0.022626159442801212 1.1060725399009005e-07 6.95621638962662 -0.5257204081601277 VYNVTQHAVGIVVNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYNVTQHAVGIVVNK 15 0 P46778;G3V1B3;M0R181 P46778 RPL21 60S ribosomal protein L21 0 504537800.0 155584000.0 119899800.0 229054000.0 False True 213107609.29950735 114602230.38038322 174956162.715208 1.0 0.5377669561264613 0.8209756718227726 27.66700686654458 -10.299840202205965 6.152065180258218 1.0000157969652437 0.6793713139746173 0.630853765479811 0.11561947402748626 2.5052409597001346e-05 2.850921498997547e-06 0.11195358546542733 0.037316024783809486 5.0137167840771636e-11 10.299840202205965 -0.3206444829906264 VYNVTQHAVGIVVNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYNVTQHAVGIVVNK 15 0 P46778;G3V1B3;M0R181 P46778 RPL21 60S ribosomal protein L21 0 274434200.0 136848000.0 78374800.0 59211400.0 False True 113795175.39432125 77952579.39622025 71592229.97741897 1.0 0.6850253459876502 0.6291323839463203 26.761864151697377 -13.999999999999998 0.24320909085225734 3.117722909589318 0.6051608839785113 0.9995304027525904 0.0035378074887073103 13.738891512090074 0.15607222538711393 14.1572770660557 0.026805767659604494 1.0000000000000041e-14 13.999999999999998 -2.5125620256108068 VYNVTQHAVGIVVNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYNVTQHAVGIVVNK 15 0 P46778;G3V1B3;M0R181 P46778 RPL21 60S ribosomal protein L21 0 574844000.0 169350000.0 269284000.0 136210000.0 False True 219226913.38756827 254298108.68033963 111421177.63262337 1.0 1.1599766869443147 0.5082458896624767 27.707849680697215 -6.841789662689418 1.2740389026245174 1.085094350578716 0.4860367925950004 0.9274900749273216 0.0746763581186854 0.16671929628227825 0.5248931456793878 0.04594648515539805 0.1059091491878071 1.4394955853176686e-07 6.841789662689418 -0.5990575579837156 VYNYNHLMPTR ddPTM_RPMI8226_Bortezomib_1h_R1 2 VYNYNHLMPTR 11 0 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 0 28995600.0 7605800.0 11158700.0 10231100.0 False True 9971277.454671983 9493865.456271928 9172483.915641142 1.0 0.9521212802902835 0.9198905513699681 23.249346914415057 VYNYNHLMPTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYNYNHLMPTR 11 0 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 0 24727300.0 7974400.0 6123900.0 10629000.0 False True 7721257.0369658675 8569205.205716614 7844946.036834984 1.0 1.109819963859661 1.0160192827770076 22.88040430974063 -10.62683351720788 3.0115076172132276 0.995271398893852 1.0629196233540223 0.37497177488935685 0.03829396806566157 11424393.658195877 8746214.744055072 401647.2845335424 0.01419977968209225 2.3613832742424506e-11 10.62683351720788 0.06764822446017038 VYNYNHLMPTR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 VYNYNHLMPTR 11 0 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 0 32401200.0 7605800.0 12004900.0 12790500.0 False True 10417869.799016578 11474483.823104465 9769647.328616256 1.0 1.1014232318575943 0.93777782954616 23.312556975937948 -6.739060422691344 1.690049884263236 1.0604115012885376 0.9376997164325259 0.6007590685370272 0.042614760440651905 0.31951637748916306 1.7915655221631315 0.019950256940163686 0.04900836021693528 1.8236419643015126e-07 6.739060422691344 -0.12271178485601164 VYNYNHLMPTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYNYNHLMPTR 11 0 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 0 14797600.0 7974400.0 3636100.0 3187100.0 False True 6631066.925818969 3616511.6075906623 3853507.874514574 1.0 0.545389097719596 0.581129389527108 22.660809585174906 -9.93185788829311 5.849494944235818 1.0000002466788311 0.5632592444850716 0.9950024834565013 0.014590913031989219 4.6939006922798194e-08 8.56539310348012e-09 0.014127598793829462 0.004709196931440855 1.169882142256243e-10 9.93185788829311 -0.43674100219375955 VYNYNHLMPTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYNYNHLMPTR 11 0 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 0 18171400.0 5641800.0 3468000.0 9061600.0 False True 7303421.316504175 3275002.751382991 7412481.7798676975 1.0 0.44842035115544865 1.014932790898571 22.80014102784403 -10.850782927476562 12.07224339243084 1.0042391011189817 0.7316765710270121 0.2302447290699735 0.23127773505164193 0.026437567635928933 0.0003267766258879545 0.22435879630420616 0.07464456801696509 1.4099933764314276e-11 10.850782927476562 -0.2725625300919696 VYPVSGGLSNLLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYPVSGGLSNLLFR 14 0 Q9Y259 Q9Y259 CHKB Choline/ethanolamine kinase 0 2673740.0 627360.0 895280.0 1151100.0 False True 822475.0353628825 761707.7137741072 1031995.2141308871 1.0 0.9261165154247334 1.254743511668488 19.649612363734825 -6.847661788844223 1.2463285960541162 0.9606385560634995 1.2672994864809095 0.9368331532883368 0.03538004227959698 0.16004720288005603 0.4795837423446546 0.022225990594975955 0.051361104262484435 1.4201630572933948e-07 6.847661788844223 0.30666093041741005 VYPVSGGLSNLLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYPVSGGLSNLLFR 14 0 Q9Y259 Q9Y259 CHKB Choline/ethanolamine kinase 0 5849060.0 627360.0 1198200.0 4023500.0 False True 859311.9457665252 1145259.562082465 3073232.1665836 1.0 1.3327634600271596 3.576387110320233 19.712822425257716 -6.933420235657975 0.718170060799106 0.9698293384455012 4.079843012972838 0.9971686544627378 0.06088231030789822 0.09090059367589189 0.06926436076225911 0.056641345645912944 0.1993295300837618 1.165681125051398e-07 6.933420235657975 3.110013674527337 up VYSHLK(ub)SVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYSHLKSVLK 10 1 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;J3QRY6;Q96HV7 Q5TA45-4 CPSF3L Integrator complex subunit 11 1 3330110.0 478410.0 1096400.0 1755300.0 True False 627200.1429290308 932821.3937337267 1573678.3940265353 1.0 1.4872786689388202 2.509052990130777 19.25856636265744 -6.959108912579987 0.4478147714206249 0.9663039617513803 3.070386616622631 0.9997357109754725 0.010222666316020517 0.08002097205195233 0.02231907302500738 0.013613458844214393 0.08454583403174419 1.098730264772976e-07 6.959108912579987 2.1040826548712506 VYSHLK(ub)SVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYSHLKSVLK 10 1 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;J3QRY6;Q96HV7 Q5TA45-4 CPSF3L Integrator complex subunit 11 1 22797000.0 2220700.0 5205300.0 15371000.0 True False 3368964.254916572 4276373.545805468 12332915.112651365 1.0 1.2693436980118291 3.660743830883054 21.68387369071107 -6.928210842277889 0.7613365127434492 0.9611183755603158 4.1300397124115245 0.996174769018682 0.07396257225616433 0.09357745092026878 0.08231021442320796 0.06667990232714187 0.21854778832056307 1.179747749965451e-07 6.928210842277889 3.168921336851209 up VYSHLK(ub)SVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYSHLKSVLK 10 1 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;J3QRY6;Q96HV7 Q5TA45-4 CPSF3L Integrator complex subunit 11 1 4597310.0 478410.0 1103000.0 3015900.0 True False 655291.1055441271 1054265.812866766 2303606.534410213 1.0 1.6088510952568884 3.5153941735519085 19.32177642418033 -6.9504831632316755 0.5535128077717312 0.9741656193239134 4.24018778568995 0.9992386636202406 0.02956489456230093 0.08329229060833739 0.03516375796029615 0.031946130029871886 0.15827161636146814 1.120770875442558e-07 6.9504831632316755 3.266022166366037 VYSHLK(ub)SVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYSHLKSVLK 10 1 Q5TA45-4;Q5TA45-3;Q5TA45;Q5TA45-5;C9IYS7;A0A087WYI0;Q5TA45-2;J3QRY6;Q96HV7 Q5TA45-4 CPSF3L Integrator complex subunit 11 1 24110900.0 2220700.0 4858200.0 17032000.0 True False 2874739.9265413177 4587836.899298978 13932350.763077915 1.0 1.5959137231654679 4.846473461632519 21.45500001280352 -6.937883400777435 0.6789672540639516 0.9618331757237585 5.671036325024963 0.9978733452588066 0.07795322672229905 0.08874561126280438 0.059106849182963335 0.0747159057725966 0.28247725420675773 1.1537629781019073e-07 6.937883400777435 4.709203149301205 VYSLFLDESR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYSLFLDESR 10 0 Q9Y230;Q9Y230-2 Q9Y230 RUVBL2 RuvB-like 2 0 7095300.0 3198400.0 1882100.0 2014800.0 False True 2659611.3131444883 1871960.7537323998 2436085.364617347 1.0 0.7038474924815835 0.9159554076859208 21.342783988895533 -9.910831927555602 5.8575223736968285 1.000000079277962 0.8099014509110717 0.517137522489252 0.08659269377652264 8.96286495626593e-08 1.6636731592678415e-08 0.08384305020665514 0.027947671741569823 1.2279143434257593e-10 9.910831927555602 -0.1900986283668903 VYSLIQSLTSQIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYSLIQSLTSQIR 13 0 A0A087WZV0;O43314-2;O43314 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 0 3429830.0 825800.0 1816300.0 787730.0 False True 1082631.7970585758 1545315.1198819485 706223.2560397221 1.0 1.4273690501982728 0.6523208148499557 20.046111235281774 -6.757029947984257 1.6237637761933132 1.249161159488542 0.6499110094856854 0.678644882193681 0.1796840731189595 0.2879552505534694 1.4956705482661623 0.08734193999017066 0.21050712539573055 1.7497260272382878e-07 6.757029947984257 -0.5992501500028565 VYSLIQSLTSQIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYSLIQSLTSQIR 13 0 A0A087WZV0;O43314-2;O43314 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 0 8188800.0 3678800.0 2348600.0 2161400.0 False True 3562018.5076733124 3286408.227787204 1595264.4993898869 1.0 0.9226252532679469 0.4478540737375066 21.764263581793784 -6.935362082241251 0.7013800116025929 1.0059885448486023 0.33558860646727984 0.9974911688044903 0.01222649506937152 0.08994752719522749 0.06473011185523798 0.011518604124254907 0.04176498644682974 1.1604806884439465e-07 6.935362082241251 -0.6703999383813225 down VYSLIQSLTSQIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYSLIQSLTSQIR 13 0 A0A087WZV0;O43314-2;O43314 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 0 8625700.0 825800.0 4169700.0 3630200.0 False True 1131120.5764058854 3985468.866646012 2772821.5263158404 1.0 3.5234695131351645 2.451393409468714 20.109321296804666 -10.51291470776444 6.569136061731426 0.9987452344200562 2.9874314613019393 0.8208584094550768 0.4376732365689876 0.008045249866421933 0.0005965337430860255 0.42388931102642874 0.14125842969269897 3.0696247808815096e-11 10.51291470776444 1.988686226881883 VYSLIQSLTSQIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYSLIQSLTSQIR 13 0 A0A087WZV0;O43314-2;O43314 A0A087WZV0 PPIP5K2 Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 0 8295800.0 3678800.0 1570500.0 3046500.0 False True 3059085.1984729692 1562039.404780156 3683509.0645755176 1.0 0.5106230469030065 1.2041211099364764 21.54466885722806 -6.717114873107875 1.7699142720921412 0.7013558522872949 1.2028546548503556 0.49881472318080655 0.2060071977519285 0.36093023146016984 2.2081002739891487 0.09248018054880713 0.23293227812807002 1.9181613101040284e-07 6.717114873107875 0.5014988025630607 VYSPHVLNLTLIDLPGITK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYSPHVLNLTLIDLPGITK 19 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3;Q9UQ16-3;E5RIK2;E5RHK8;Q9UQ16-2;Q9UQ16-5;Q9UQ16;Q9UQ16-4 P50570 DNM2;DNM3 Dynamin-2;Dynamin-3 0 11584100.0 4930800.0 4569900.0 2083400.0 False True 6464326.549935124 3888088.7333306842 1867829.7533839706 1.0 0.6014684906921519 0.28894421390310426 22.62406864799441 -7.836661438439844 0.25256448286423216 1.158174948349706 5.563246501080631e-10 0.999687864399635 0.005141097655864532 0.1187254061784582 0.039317742343529756 0.051475624175477484 0.08767950760624674 1.4565941505360376e-08 7.836661438439844 -1.1581749477933814 down VYSPHVLNLTLIDLPGITK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYSPHVLNLTLIDLPGITK 19 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3;Q9UQ16-3;E5RIK2;E5RHK8;Q9UQ16-2;Q9UQ16-5;Q9UQ16;Q9UQ16-4 P50570 DNM2;DNM3 Dynamin-2;Dynamin-3 0 47442000.0 20300000.0 11273000.0 15869000.0 False True 19655587.611658193 15774367.687918404 11712432.840204572 1.0 0.8025385961273553 0.5958831184094263 24.22843615856389 -6.970552225416445 0.24465580303105808 1.070048929236622 0.32236098091806115 0.9999863690227292 0.0006091339711869 0.07612409037067143 0.008387328691668089 0.004781249022515422 0.019983719282158394 1.0701576850032284e-07 6.970552225416445 -0.7476879483185608 VYSPHVLNLTLIDLPGITK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYSPHVLNLTLIDLPGITK 19 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3;Q9UQ16-3;E5RIK2;E5RHK8;Q9UQ16-2;Q9UQ16-5;Q9UQ16;Q9UQ16-4 P50570 DNM2;DNM3 Dynamin-2;Dynamin-3 0 71774000.0 15960000.0 30494000.0 25320000.0 False True 24212486.83229097 25052107.449290514 20315490.901849758 1.0 1.0346771739233238 0.8390501579852597 24.529247928445592 -6.861094304580019 1.1800832134077308 1.0188738741644958 0.8293720361856644 0.9549637089563574 0.018087289141927282 0.1456848887870328 0.3848738916739946 0.011948340490136438 0.027928320173550885 1.3769104481466203e-07 6.861094304580019 -0.18950183797883147 VYSPHVLNLTLIDLPGITK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYSPHVLNLTLIDLPGITK 19 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3;Q9UQ16-3;E5RIK2;E5RHK8;Q9UQ16-2;Q9UQ16-5;Q9UQ16;Q9UQ16-4 P50570 DNM2;DNM3 Dynamin-2;Dynamin-3 0 23220900.0 4930800.0 1908100.0 16382000.0 False True 6753850.009859699 1823793.8327570942 12512908.997880599 1.0 0.27003765705406607 1.8527075637767287 22.6872787095173 -6.781296747630289 1.5308524004119317 0.5873760794767238 1.8657508402345888 0.7719453766277397 0.3088652841322446 0.24856259145799217 1.150650041464133 0.15889864353894062 0.37452436104146936 1.6546389843605728e-07 6.781296747630289 1.278374760757865 VYSPHVLNLTLIDLPGITK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYSPHVLNLTLIDLPGITK 19 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3;Q9UQ16-3;E5RIK2;E5RHK8;Q9UQ16-2;Q9UQ16-5;Q9UQ16;Q9UQ16-4 P50570 DNM2;DNM3 Dynamin-2;Dynamin-3 0 45609900.0 20300000.0 9125900.0 16184000.0 False True 16880349.44248157 9076736.96535068 19567999.57363865 1.0 0.5377102527574402 1.1592176832781236 24.008841433998168 -6.707531706789868 1.803767614900801 0.7150758619941636 1.1576655205709183 0.4533800980371928 0.19488451654398173 0.3801109133888101 2.409155366424534 0.08602522145708884 0.21922043456856474 1.9609580054480765e-07 6.707531706789868 0.4425896585767547 VYSPHVLNLTLIDLPGITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYSPHVLNLTLIDLPGITK 19 0 P50570;P50570-5;P50570-2;P50570-4;P50570-3;Q9UQ16-3;E5RIK2;E5RHK8;Q9UQ16-2;Q9UQ16-5;Q9UQ16;Q9UQ16-4 P50570 DNM2;DNM3 Dynamin-2;Dynamin-3 0 43600000.0 15960000.0 15808000.0 11832000.0 False True 20660534.618633535 14928270.903651198 9678697.406572206 1.0 0.7225500781662996 0.4684630666741355 24.30037425053804 -6.972176653819545 0.1994588611726437 1.152298740679635 0.03170318342575492 0.9999947534072247 0.0004971723984816904 0.07560252682676927 0.006435959101117375 0.008286229209826246 0.027011478747969216 1.0661623603347816e-07 6.972176653819545 -1.1205955572538802 down VYSTALSSFLTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYSTALSSFLTKR 13 1 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 1 8945200.0 2155700.0 4038500.0 2751000.0 True False 2087268.4834705202 5651094.110499287 2030430.5717690317 1.0 2.707411219616157 0.9727692378093192 20.993184754325434 -6.649759151792476 2.0090596013856614 2.108120484808626 0.9800070148762705 0.19323558507951488 0.7287783475927461 0.509098997379788 3.938370658664696 0.29419415992373765 0.8073734022308491 2.239963018293444e-07 6.649759151792476 -1.1281134699323556 VYSTALSSFLTK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYSTALSSFLTKR 13 1 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 1 19206500.0 3725900.0 4508600.0 10972000.0 True False 5652462.699776495 3704005.104147416 8803379.39080157 1.0 0.6552904991825734 1.5574413947304182 22.430448136084255 -6.803125231231858 1.442980683640414 0.8105577937797552 1.5708992798543584 0.8411926072072737 0.14812447768568401 0.21631782910585465 0.8888548123455997 0.0807416957805165 0.187441212764237 1.5735290631750675e-07 6.803125231231858 0.7603414860746032 VYSTALSSFLTK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYSTALSSFLTKR 13 1 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 1 9689700.0 2348200.0 4051100.0 3290400.0 True False 3216392.997718941 3872109.0068037678 2513275.287915167 1.0 1.203866881177101 0.7813955849604126 21.61701226353398 -6.775465212846779 1.553286318789388 1.1161137886193817 0.7784980480483977 0.7511028693847187 0.08606361627866894 0.2576850261375753 1.227601191022772 0.04365278452682273 0.10341030743992459 1.6770066592402356e-07 6.775465212846779 -0.337615740570984 VYSTALSSFLTK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYSTALSSFLTKR 13 1 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 1 9801100.0 2155700.0 4229100.0 3416300.0 True False 1792560.0637023407 4206316.998889374 4130632.5348135037 1.0 2.346541733280433 2.304320295009878 20.77359002975971 -10.510178925867452 6.278825108680596 0.9988860753672418 2.325431014145143 0.9992395289113434 0.017236829994879802 0.00026893381914585017 2.0979901563425606e-05 0.01669915820622359 0.005563162959298113 3.089022517642547e-11 10.510178925867452 1.326544938777901 VYSTALSSFLTK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYSTALSSFLTKR 13 1 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 1 18842700.0 3725900.0 2657800.0 12459000.0 True False 4823250.998469087 2509891.0936060324 10191589.840135498 1.0 0.5203733113625392 2.113012539337127 22.201574458176704 -6.825947432832526 1.345881182617399 0.7429155144108175 2.152440306831632 0.8975317806470963 0.21354674008543972 0.18586517095176391 0.6598505251009877 0.12462668546349467 0.28690220723666215 1.492975108911669e-07 6.825947432832526 1.4095247924208145 up VYSYALALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYSYALALK 9 0 A6NFX8;Q9UKK9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 52712000.0 14474000.0 20879000.0 17359000.0 False True 18975554.16641539 17763934.585704584 15562857.199285947 1.0 0.9361483954521214 0.8201529748643898 24.177638683262813 -6.961881328333008 0.4080610276649178 1.0058362692556804 0.7461740031531475 0.9998337164480836 0.0009599427669422324 0.07903587698300496 0.018698205381855747 0.0014929666105747985 0.009690907189462259 1.0917386150301083e-07 6.961881328333008 -0.25966226610253285 VYSYALALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYSYALALK 9 0 A6NFX8;Q9UKK9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 52587900.0 20682000.0 6883900.0 25022000.0 False True 20025461.230754428 9632677.16906425 18467987.55609038 1.0 0.48102148849738896 0.9222253282100623 24.255332135692417 -10.149689525179147 7.672787374600007 1.000000089230489 0.7016234083537266 0.37880603784977607 0.18012071330879115 2.7499271605399185e-07 3.048309183612162e-08 0.17440118271314717 0.058133710245995715 7.084520720188178e-11 10.149689525179147 -0.2983766808767624 VYSYALALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYSYALALK 9 0 A6NFX8;Q9UKK9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 60210000.0 15889000.0 21722000.0 22599000.0 False True 24104774.64149571 17845539.38523937 18132297.744506415 1.0 0.740332139613484 0.7522284698439853 24.522815606075284 -10.523041426307971 5.904822328295545 1.0003872563479639 0.7462803047287346 0.9983538703277334 0.004856656479395863 2.479675850770398e-05 2.0029429082944296e-06 0.004709484026571421 0.0015674791385791858 2.9988764497193246e-11 10.523041426307971 -0.25410695161922925 VYSYALALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYSYALALK 9 0 A6NFX8;Q9UKK9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 46756000.0 14474000.0 10877000.0 21405000.0 False True 19825428.945142634 10396418.174570996 16349579.84981283 1.0 0.5243981456006878 0.8246772311990046 24.240848744785705 -10.643772961108356 5.0855155437816375 1.0050222989521667 0.6745376883998525 0.6103421731908061 0.12258842335756968 0.007063793694752003 0.0004947995671646853 0.12011144120976727 0.039565243508473645 2.2710517938112088e-11 10.643772961108356 -0.33048461055231415 VYSYALALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYSYALALK 9 0 A6NFX8;Q9UKK9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 45841600.0 20682000.0 15676000.0 9483600.0 False True 17197999.367950935 15591550.276557636 11466576.91278792 1.0 0.906590932059983 0.6667390007093663 24.035737411126693 -6.954886023349136 0.5023495732395998 1.0047072007702302 0.5582362997724799 0.9995310227680654 0.003039688969398432 0.08158108921025041 0.028286746466388447 0.0035492150022868123 0.019787359970826368 1.1094659463411546e-07 6.954886023349136 -0.44647090099775033 VYSYALALK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYSYALALK 9 0 A6NFX8;Q9UKK9 A6NFX8 NUDT5 ADP-sugar pyrophosphatase 0 55119000.0 15889000.0 27831000.0 11399000.0 False True 20568623.719014317 26282180.384584785 9324498.96361701 1.0 1.2777802124061741 0.45333606618497935 24.293941928167733 -6.815807888148597 1.389775135842226 1.1503865940591627 0.43688475148985373 0.8745058616430085 0.12132857083496411 0.19898040385520407 0.7562566072472283 0.0686203089530456 0.1583731296812753 1.5282419324956582e-07 6.815807888148597 -0.7135018425693089 down VYSYFECR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYSYFECR 8 0 P43490;A0A0C4DFS8;C9JG65;C9JF35 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 19969600.0 6476000.0 5572900.0 7920700.0 False True 8490098.713673204 4741445.042994062 7101141.944719407 1.0 0.5584675988935229 0.8364027538670548 23.017349897295524 -10.356077133476209 6.348744451711806 1.0000247011236159 0.6974351763802892 0.6124203466137847 0.11346655187775334 3.967440599197741e-05 4.023804706018414e-06 0.10987247215919478 0.036621172147843196 4.4047662509457916e-11 10.356077133476209 -0.3025895247433267 VYSYFECR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYSYFECR 8 0 P43490;A0A0C4DFS8;C9JG65;C9JF35 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 5097840.0 2971100.0 725640.0 1401100.0 False True 2470601.2920471434 721730.8332917374 1694063.5320455474 1.0 0.29212760295033696 0.6856887582382198 21.23643077529717 -10.748819831460052 6.8889181021682795 1.0095090979224235 0.4889081805955626 0.6921750591578157 0.16067066883926112 0.02337005916297657 0.0008521060075015125 0.15493632516191666 0.051856235386538746 1.7831183467275927e-11 10.748819831460052 -0.5206009173268609 VYTLSVSGDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYTLSVSGDR 10 0 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 56520000.0 17315000.0 13485000.0 25720000.0 False True 22700132.678698506 11473090.564118313 23058741.123661187 1.0 0.5054195376965573 1.0157976365177457 24.43619739407755 -10.896276367430055 11.926179093406583 1.013870175290876 0.7606085871071515 0.2268083211986247 0.20836098633394667 0.07100615491829118 0.0006175491248549334 0.1864215718941566 0.06724821917256057 1.2697658204820588e-11 10.896276367430055 -0.2532615881837246 VYTLSVSGDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYTLSVSGDR 10 0 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 38156100.0 9357300.0 3699800.0 25099000.0 False True 9060257.633427063 5177149.434202113 18524818.946139913 1.0 0.5714130484658022 2.044623861223785 23.111120644008817 -6.828858233557493 1.3330462879177603 0.770808910334233 2.0833400880552935 0.9035697435821434 0.19213098448071247 0.1822196401361081 0.633689900273824 0.1131796200786002 0.2604668402376423 1.4830021014768373e-07 6.828858233557493 1.3125311777210604 up VYTLSVSGDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYTLSVSGDR 10 0 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 39230800.0 0.0 29559000.0 9671800.0 False True 0.0 24283965.504478864 7760164.490699475 0.0 VYTLSVSGDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYTLSVSGDR 10 0 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 55075000.0 17315000.0 13941000.0 23819000.0 False True 23716823.420280807 13325040.523277942 18193442.767703433 1.0 0.5618391758098342 0.7671112798413718 24.49940745560044 -10.03758878604991 4.899138472475735 1.0000064675343263 0.6644752278214751 0.7808113464901834 0.08380198556505901 5.9200084209530126e-06 1.1629535651805099e-06 0.08114248775280054 0.02704697453734824 9.170884290176876e-11 10.03758878604991 -0.33553123971285126 VYTLSVSGDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYTLSVSGDR 10 0 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 24022300.0 9357300.0 8942800.0 5722200.0 False True 7781009.5486765 8894623.36139319 6918685.563536532 1.0 1.143119450728101 0.8891758222701778 22.891525919443094 -6.753761114483312 1.6356635425029347 1.083771185859148 0.8885139804196995 0.6651269085812199 0.060154670255409624 0.29351583961392336 1.5460554209307027 0.02903721990939179 0.07022568848429878 1.7629454953888277e-07 6.753761114483312 -0.19525720543944836 VYTLSVSGDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYTLSVSGDR 10 0 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 32445000.0 0.0 21525000.0 10920000.0 False True 0.0 20327114.82800428 8932672.04866197 0.0 VYTVNNVNVITK(ub)IR ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYTVNNVNVITKIR 14 1 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 12158200.0 3827300.0 5873000.0 2457900.0 True False 5017627.36362592 4996771.292774698 2203580.0858416352 1.0 0.99584343966983 0.4391677432676563 22.25857390164738 -6.908536702203907 0.9056406073452654 1.0180435819617317 0.3694334979669541 0.9903575723583184 0.02586524317775964 0.1053936863447114 0.14407442700772738 0.021024184288202602 0.057464487024016804 1.234420989909321e-07 6.908536702203907 -0.6486100839947776 down VYTVNNVNVITK(ub)IR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYTVNNVNVITKIR 14 1 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 23443500.0 4859600.0 6323900.0 12260000.0 True False 4705334.658010557 8849066.248702828 9048738.207883786 1.0 1.880645457095769 1.9230806872533155 22.16586590487785 -11.06887037379716 0.5251070190584897 1.6683001061341962e-09 1.920271368848752 0.9998387322406521 0.005403412772512791 2.9973341763494075 0.25628899549728357 3.59207067070261 0.008250908686789018 8.533547813872924e-12 11.06887037379716 1.9202713671804519 VYTVNNVNVITK(ub)IR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYTVNNVNVITKIR 14 1 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 42886000.0 11354000.0 12490000.0 19042000.0 True False 17224848.088585936 10261061.915184584 15278340.353594908 1.0 0.5957127669523011 0.8869942001821843 24.03798792361076 -9.932549448148489 6.3021952013602505 1.0000000484646285 0.7413534835672233 0.5125041116984675 0.11891514716003358 8.101308854758061e-08 1.3884217565278373e-08 0.11513911672904188 0.03837969871354092 1.1680207331201385e-10 9.932549448148489 -0.25864656489740523 VYTVNNVNVITK(ub)IR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYTVNNVNVITKIR 14 1 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 13897700.0 3827300.0 4435000.0 5635400.0 True False 5242356.238893488 4239047.035416233 4304434.584706158 1.0 0.8086148369632689 0.8210877682770185 22.321783963170272 -10.796217393041127 10.427797345885198 1.0013884074421386 0.8148513026205304 0.9966077969369239 0.00509205288591146 0.00016541234388458198 3.2325198803386612e-06 0.004961830001836518 0.001643453002095212 1.5987575446534267e-11 10.796217393041127 -0.18653710482160824 VYTVNNVNVITK(ub)IR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYTVNNVNVITKIR 14 1 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 23029600.0 4859600.0 10789000.0 7381000.0 True False 4040972.7167824428 10730877.515551174 8924332.974111892 1.0 2.6555184277748496 2.20846157585982 21.946271180312127 -10.565075256898243 5.533799541583103 0.9943875350728321 2.4319900018173355 0.9318811466387124 0.18251019553447098 0.012622228842287692 0.0009920333727562655 0.1764992470424413 0.05890491231817157 2.7222295445359303e-11 10.565075256898243 1.4376024667445035 VYTVNNVNVITK(ub)IR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYTVNNVNVITKIR 14 1 Q8IZ07;H0YIN8 Q8IZ07 ANKRD13A Ankyrin repeat domain-containing protein 13A 1 37300700.0 11354000.0 20423000.0 5523700.0 True False 14697976.820799815 19286442.096740175 4518443.277948182 1.0 1.3121834611582053 0.307419404251197 23.80911424570321 -6.823233443831959 1.3578106269772532 1.1677317067383468 0.2839200460041408 0.8916789458219295 0.13819090950451027 0.18929976239910623 0.6848678483628676 0.07995917935893268 0.18415490342599455 1.502334207889933e-07 6.823233443831959 -0.883811660734206 down VYVAK(ub)VDCTAHSDVCSAQGVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYVAKVDCTAHSDVCSAQGVR 21 1 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 1 24613600.0 1410300.0 7376300.0 15827000.0 True False 2139528.206740598 6059941.633705052 12698786.512779472 1.0 2.8323728636122505 5.935320914569791 21.028861268363414 -6.963163693699336 0.3882799945177845 0.8057379391865914 8.073141440811632 0.9998701462189868 0.023211980702648665 0.07858974006145679 0.017092289464940676 0.040104052567893934 0.26120722676180336 1.088519732590025e-07 6.963163693699336 7.267403501625041 VYVAK(ub)VDCTAHSDVCSAQGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYVAKVDCTAHSDVCSAQGVR 21 1 Q8NBS9;Q8NBS9-2 Q8NBS9 TXNDC5 Thioredoxin domain-containing protein 5 1 15113400.0 1410300.0 4091500.0 9611600.0 True False 1825661.1511691022 3863804.428282441 7862387.423344273 1.0 2.1163863983237903 4.306597321364603 20.799987590455864 -6.960419519736211 0.42948042496814476 0.9125205244659279 5.594382217405697 0.9997854435592199 0.020117734068664427 0.07955159732483265 0.02058009545131147 0.028545709840467875 0.18187731650365774 1.095419531661613e-07 6.960419519736211 4.681861692939769 VYVGNLGNNGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYVGNLGNNGNK 12 0 P84103;P84103-2;A0A087X2D0 P84103 SRSF3 Serine/arginine-rich splicing factor 3 0 25576000.0 1739400.0 13972000.0 9864600.0 False True 2280370.2443735623 11887432.062429426 8843905.819924893 1.0 5.212939474087467 3.878276276295822 21.12083665088815 -10.15735981111226 7.543875210220547 0.9999984407418605 4.545607875191644 0.9039359511953948 0.5448739688434716 1.428894312093488e-05 1.596490976289374e-06 0.5275721872294907 0.17585731725939213 6.960496010549592e-11 10.15735981111226 3.5456094344497835 VYVGNLGNNGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYVGNLGNNGNK 12 0 P84103;P84103-2;A0A087X2D0 P84103 SRSF3 Serine/arginine-rich splicing factor 3 0 29901400.0 7666300.0 4402100.0 17833000.0 False True 7422937.502820466 6159881.486648228 13162002.321467508 1.0 0.8298441801925021 1.7731527870827946 22.823558791493443 -6.860230704829741 1.1846444910935825 0.9076317505128266 1.8190181584988503 0.9539165740264952 0.088120996375435 0.14655919276320808 0.3907088008263569 0.05801446310590156 0.135451596579632 1.3796511750544976e-07 6.860230704829741 0.9113864079860237 VYVGNLGNNGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYVGNLGNNGNK 12 0 P84103;P84103-2;A0A087X2D0 P84103 SRSF3 Serine/arginine-rich splicing factor 3 0 28666400.0 1739400.0 12171000.0 14756000.0 False True 2382503.1855175565 11633244.975885222 11270936.709359424 1.0 4.882782548455693 4.730712125747279 21.184046712411043 -10.161072083378668 4.457106678696403 0.9993092190805218 4.806747337213263 0.9988045726283858 0.06208249049132957 2363477.1294492926 2694189.1232432234 13221.97515715398 0.021252487723794795 6.901252486470532e-11 10.161072083378668 3.8074381181327412 VYVGNLGNNGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYVGNLGNNGNK 12 0 P84103;P84103-2;A0A087X2D0 P84103 SRSF3 Serine/arginine-rich splicing factor 3 0 9719290.0 7666300.0 1239100.0 813890.0 False True 6374868.124674714 1232424.7223579062 984070.6359978229 1.0 0.19332552427047928 0.15436721462344546 22.60396406692772 -13.34113233889692 0.43858270209221 9.99836994538918 0.15392560354684592 0.9998760086152603 0.004340220389123706 18.23611656441173 0.22296729373369348 155.02161241100438 0.009033578332616414 4.558979728362677e-14 13.34113233889692 -9.844444341842335 VYVGNLGNNGNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYVGNLGNNGNK 12 0 P84103;P84103-2;A0A087X2D0 P84103 SRSF3 Serine/arginine-rich splicing factor 3 0 5508300.0 2570500.0 0.0 2937800.0 False True 3327562.9221301656 0.0 2403150.5443735505 1.0 0.0 0.7221953725927306 21.66603451617866 -10.628461864435693 8.916740064838965 1.000310831826591 0.36109768809633164 0.5106468421826771 0.29483502624189484 0.001822662349816469 7.594623145129137e-05 0.285600021849862 0.09515759554279052 2.3525460622875042e-11 10.628461864435693 -0.6392131437302593 VYVGNLGNNGNK(ub)TELER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYVGNLGNNGNKTELER 17 1 P84103;P84103-2;A0A087X2D0 P84103 SRSF3 Serine/arginine-rich splicing factor 3 1 97275900.0 64234000.0 28087000.0 4954900.0 True False 62194926.82991401 39302285.57177008 3657063.046186249 1.0 0.631921083840986 0.058800021683236454 25.8902935703581 -7.5461147694987085 0.5904791839166994 1.0032062809172797 9.389423764803217e-22 0.9934046342226742 0.031450970972429576 0.11697233114038352 0.10278069528378996 0.030426764209878242 0.07294585579174596 2.8437095108771126e-08 7.5461147694987085 -1.0032062809172797 down VYVGNLGNNGNK(ub)TELER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYVGNLGNNGNKTELER 17 1 P84103;P84103-2;A0A087X2D0 P84103 SRSF3 Serine/arginine-rich splicing factor 3 1 88967600.0 39355000.0 45205000.0 4407600.0 True False 53905607.02888547 43207693.62705538 3366615.65737141 1.0 0.8015435871801316 0.062453904944756486 25.68393200791379 -7.188114449092388 0.7541974969518505 0.9951965294379582 1.6162856733779157e-25 0.9948535940114098 0.028939758140306616 0.08765402700670973 0.08986955697664067 0.025778120424154918 0.05939424921497436 6.484635222321799e-08 7.188114449092388 -0.9951965294379582 down VYVGNLGNNGNK(ub)TELER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYVGNLGNNGNKTELER 17 1 P84103;P84103-2;A0A087X2D0 P84103 SRSF3 Serine/arginine-rich splicing factor 3 1 108561400.0 64234000.0 42130000.0 2197400.0 True False 53413417.04868783 41903037.32784975 2656866.180370341 1.0 0.7845039625466006 0.04974155047875954 25.670698845792376 -7.229345172844504 0.7546651399682098 0.9937515453977362 1.9658833476206516e-19 0.9937212880826773 0.03223338447940082 0.09282920039330382 0.09815061621832685 0.02840127584574071 0.06218066465277048 5.8973218070902e-08 7.229345172844504 -0.9937515453977362 down VYVGNLGNNGNK(ub)TELER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYVGNLGNNGNKTELER 17 1 P84103;P84103-2;A0A087X2D0 P84103 SRSF3 Serine/arginine-rich splicing factor 3 1 103882200.0 71533000.0 26625000.0 5724200.0 True False 92600878.62623504 25143295.34474401 4682454.335251908 1.0 0.27152329133106723 0.050565981713323695 26.464522546505886 -9.743744410923432 0.334085566410386 1.3799920030933475 2.9236563700459647e-25 0.9985205433533333 0.015602580380868623 1.1482030888904633 0.1487021464174075 0.5245258590366579 0.06837599474169087 1.8040791572222907e-10 9.743744410923432 -1.3799920030933475 VYVGNLGTGAGK(ub)GELER ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYVGNLGTGAGKGELER 17 1 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 1 42977000.0 17358000.0 18108000.0 7511000.0 True False 22756506.095111094 15406356.984431172 6733833.770599503 1.0 0.6770088923158992 0.2959080687718652 24.439775735643714 -7.229135916031552 0.3252428052388222 1.0588496637663605 1.0743977423395933e-16 0.9998626001104564 0.0033731741801490698 0.09373129149157498 0.019662957550055135 0.010145856436967138 0.043501266799321946 5.9001640078751464e-08 7.229135916031552 -1.0588496637663605 down VYVGNLGTGAGK(ub)GELER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYVGNLGTGAGKGELER 17 1 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 1 79544000.0 33098000.0 31283000.0 15163000.0 True False 32047322.10692926 43774465.038689874 11191355.419750566 1.0 1.3659320704747737 0.3492134345081761 24.933700473646443 -6.809348835254822 1.4171925986293032 1.199583724021257 0.3316769042426079 0.8581414446604301 0.15836585759570979 0.20768828415746948 0.8222352864596241 0.08786829111118845 0.20332523559451704 1.5511405978680967e-07 6.809348835254822 -0.8679068197786491 down VYVGNLGTGAGK(ub)GELER ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYVGNLGTGAGKGELER 17 1 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 1 74574000.0 32742000.0 22547000.0 19285000.0 True False 49672007.76083153 18523311.68948495 15473311.29708422 1.0 0.37291248178800945 0.31150968109820554 25.565929726429683 -13.999999999999998 0.3285353641783791 7.766354804965131 0.30044793283555615 0.999711793678786 0.005281366295108869 18.700392464951342 0.18321135475127545 87.3650767677022 0.019785055186263497 1.0000000000000041e-14 13.999999999999998 -7.465906872129574 VYVGNLGTGAGK(ub)GELER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYVGNLGTGAGKGELER 17 1 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 1 46805000.0 17358000.0 20685000.0 8762000.0 True False 23775721.68231211 19771068.30385227 6692596.059054428 1.0 0.8315654333454328 0.2814886609323564 24.502985797166605 -6.949528205356464 0.5640012954990462 1.007049233155496 0.07953469605644771 0.9991637234023557 0.008872581205726428 0.08367578860243384 0.03675096958203033 0.009465584793374426 0.045767080071537444 1.1232380183502348e-07 6.949528205356464 -0.9275145370990484 down VYVGNLGTGAGK(ub)GELER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYVGNLGTGAGKGELER 17 1 A0A0B4J1Z1;C9JAB2;Q16629-3;Q16629-2;Q16629-4;Q16629 A0A0B4J1Z1 SRSF7 Serine/arginine-rich splicing factor 7 1 70244000.0 32742000.0 37502000.0 0.0 True False 42385164.44130948 35414980.73309259 0.0 1.0 0.8355513349991017 0.0 25.337056048522133 -7.19804988112654 0.8941864472666881 0.990870453654399 9.554381634197475e-20 0.9893647278170405 0.04515142240374514 0.09260668356449527 0.14079676967514307 0.03803413248587865 0.06677362946315382 6.337969119907493e-08 7.19804988112654 -0.990870453654399 down VYVGSIYYELGEDTIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYVGSIYYELGEDTIR 16 0 A0A0J9YYL3;Q9UHX1-2;Q9UHX1-6;Q9UHX1-4;A0A0J9YVP6;Q9UHX1;Q9UHX1-5;Q9UHX1-3;A0A0J9YXX5;A0A0J9YXJ8;A0A0J9YVR6;E9PQ56;A0A0J9YWM1;H0YEM1;E9PN18;E9PMU7;E9PL19 A0A0J9YYL3 PUF60 Poly(U)-binding-splicing factor PUF60 0 9395900.0 3279000.0 2104600.0 4012300.0 False True 3174909.9398338567 2944977.7553440137 2961358.2635801113 1.0 0.92757836006464 0.9327377216044999 21.598284237997053 -10.407672664236987 8.182764322637977 1.0000009936682717 0.9301580408345947 0.9959238537503885 0.002106300528532789 3.818355289428863e-08 2.7650507220159926e-09 0.0020394457239136603 0.000679805572426278 3.9113559083051e-11 10.407672664236987 -0.06984295283367692 VYVGSIYYELGEDTIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYVGSIYYELGEDTIR 16 0 A0A0J9YYL3;Q9UHX1-2;Q9UHX1-6;Q9UHX1-4;A0A0J9YVP6;Q9UHX1;Q9UHX1-5;Q9UHX1-3;A0A0J9YXX5;A0A0J9YXJ8;A0A0J9YVR6;E9PQ56;A0A0J9YWM1;H0YEM1;E9PN18;E9PMU7;E9PL19 A0A0J9YYL3 PUF60 Poly(U)-binding-splicing factor PUF60 0 22439400.0 6069400.0 16370000.0 0.0 False True 9207723.532575617 13448645.600606225 0.0 1.0 1.4605831238336848 0.0 23.1344130856603 -6.845097267964563 1.417417964503036 1.2460890070182697 1.3651686338045697e-22 0.8879697114169008 0.20406714429682704 0.17932805723258646 0.7236979370989018 0.11561277786507197 0.24574457023070195 1.4285739681595647e-07 6.845097267964563 -1.2460890070182697 down VYVGSIYYELGEDTIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYVGSIYYELGEDTIR 16 0 A0A0J9YYL3;Q9UHX1-2;Q9UHX1-6;Q9UHX1-4;A0A0J9YVP6;Q9UHX1;Q9UHX1-5;Q9UHX1-3;A0A0J9YXX5;A0A0J9YXJ8;A0A0J9YVR6;E9PQ56;A0A0J9YWM1;H0YEM1;E9PN18;E9PMU7;E9PL19 A0A0J9YYL3 PUF60 Poly(U)-binding-splicing factor PUF60 0 4941200.0 3279000.0 1662200.0 0.0 False True 2726633.784329908 1653245.3986791314 0.0 1.0 0.6063320304253582 0.0 21.37868951343133 -7.636178946271648 0.6662982985039806 0.997773978220052 2.56374291103154e-21 0.9872245193101846 0.04649027700156065 0.1211213847351788 0.1481973215111164 0.04249086133574349 0.07747224046282129 2.3111123255107325e-08 7.636178946271648 -0.997773978220052 down VYVGSIYYELGEDTIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYVGSIYYELGEDTIR 16 0 A0A0J9YYL3;Q9UHX1-2;Q9UHX1-6;Q9UHX1-4;A0A0J9YVP6;Q9UHX1;Q9UHX1-5;Q9UHX1-3;A0A0J9YXX5;A0A0J9YXJ8;A0A0J9YVR6;E9PQ56;A0A0J9YWM1;H0YEM1;E9PN18;E9PMU7;E9PL19 A0A0J9YYL3 PUF60 Poly(U)-binding-splicing factor PUF60 0 18875400.0 6069400.0 6698500.0 6107500.0 False True 7856957.9457603 6325722.58654527 4995997.668242033 1.0 0.8051109131822066 0.6358692133433052 22.905539407752748 -6.972776037235418 0.17991622388946377 1.130978146589052 0.3054257549732749 0.9999967213862897 0.00026933074543138033 0.07541175992507354 0.005673419747186493 0.006522107602523438 0.018997468064459407 1.0646919311968636e-07 6.972776037235418 -0.8255523916157772 VYYFNHITNASQWER ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYYFNHITNASQWER 15 0 Q13526;K7EMU7 Q13526 PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 13530800.0 3922000.0 2202400.0 7406400.0 False True 3797498.2567942576 3081829.805364277 5466441.652762683 1.0 0.8115421250952389 1.4394849669733096 21.85661787179614 -6.8262450595274755 1.344611826820107 0.899010721814831 1.45512183892025 0.8981525946674581 0.08396325264961105 0.18549062738675742 0.657190595754714 0.04904678669517633 0.1129033623549925 1.4919523074671984e-07 6.8262450595274755 0.556111117105419 VYYFNHITNASQWER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYYFNHITNASQWER 15 0 Q13526;K7EMU7 Q13526 PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 8924800.0 3922000.0 2630300.0 2372500.0 False True 3261316.77405974 2616130.051826327 2868578.780799412 1.0 0.802169869739371 0.8795768640494738 21.637023147230416 -10.33977764786106 4.8532489017924405 1.000099429544032 0.840873366906292 0.8492752987999058 0.031601273097332114 3.4019585677595195e-05 4.627956921769181e-06 0.03061688209760982 0.010199267035369157 4.5732227170199946e-11 10.33977764786106 -0.15922606263773997 VYYFNHITNASQWERPSGNSSSGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYYFNHITNASQWERPSGNSSSGGK 25 1 Q13526;K7EMU7 Q13526 PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 33782000.0 10724000.0 10118000.0 12940000.0 False True 14059267.851363722 8608433.839655092 11601092.929244783 1.0 0.612296026412221 0.8251562636044023 23.74501813097552 -10.099362308172338 5.151831155742895 1.0000064446011525 0.7187261450078078 0.699531526779119 0.08689982794319633 6.4325794070314135e-06 1.1246539325999341e-06 0.08414232320434126 0.028046798867438407 7.95495435116843e-11 10.099362308172338 -0.28128029959334466 VYYFNHITNASQWERPSGNSSSGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYYFNHITNASQWERPSGNSSSGGK 25 1 Q13526;K7EMU7 Q13526 PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 28404100.0 10392000.0 3405100.0 14607000.0 False True 10062111.648293214 4764774.187361924 10780988.499393016 1.0 0.4735362073000004 1.0714439350533087 23.262429767051874 -6.674182348140836 1.9223410038805637 0.6651828055236368 1.0690885893216269 0.2978138129215476 0.22341591697128355 0.45157237383104115 3.2209683305036205 0.09342843811608652 0.24828267591376943 2.1174718811867103e-07 6.674182348140836 0.40390578379799 VYYFNHITNASQWERPSGNSSSGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYYFNHITNASQWERPSGNSSSGGK 25 1 Q13526;K7EMU7 Q13526 PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 34598000.0 10724000.0 12410000.0 11464000.0 False True 14688952.605203088 11861685.165617902 8756439.308491219 1.0 0.8075242316062945 0.5961241447119607 23.80822819249841 -6.96992014395171 0.26008574875987406 1.059288640422353 0.33808710632557826 0.9999817522669265 0.0007045649045313852 0.07632863147798427 0.009122787884972786 0.004410585340275109 0.019943367102380462 1.071716349336228e-07 6.96992014395171 -0.7212015340967747 VYYFNHITNASQWERPSGNSSSGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYYFNHITNASQWERPSGNSSSGGK 25 1 Q13526;K7EMU7 Q13526 PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 21991300.0 10392000.0 6953000.0 4646300.0 False True 8641408.443658559 6915542.80893755 5617819.847936073 1.0 0.8002795903036473 0.6501046541850101 23.04283504248615 -6.97427162573905 0.1176408421422256 1.280143318813742 0.16638860171127554 0.9999994910651867 0.00010208140001179436 0.07493938787300576 0.0034968453679454247 0.010874787789338987 0.021941869156456198 1.0610317364789403e-07 6.97427162573905 -1.1137547171024667 VYYFNHITNASQWERPSGNSSSGGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYYFNHITNASQWERPSGNSSSGGK 25 1 Q13526;K7EMU7 Q13526 PIN1 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 0 43738000.0 9566000.0 17960000.0 16212000.0 False True 12383375.574050654 16960510.21189115 13261582.349167397 1.0 1.3696193021418064 1.0709182056108373 23.56190129541464 -10.09598220949738 5.559702987507064 0.9999979256478608 1.2202687538763786 0.4203083042093434 0.12194421201864934 3.1354941065837335e-06 5.096643539112218e-07 0.11807308745098505 0.039357325192855584 8.017109041176573e-11 10.09598220949738 0.22027082822851773 VYYVDHVEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 VYYVDHVEKR 10 1 A0A590UJQ1;Q96J02-3;Q96J02-2;Q96J02;A0A590UK44;A0A590UK95 A0A590UJQ1 ITCH E3 ubiquitin-protein ligase Itchy homolog 1 5524500.0 2403400.0 1783200.0 1337900.0 True False 3150880.6745587047 1517153.5108591584 1199466.942043013 1.0 0.48150141740027735 0.3806767268998544 21.587323689124858 -13.999999999999998 0.2302392662585513 4.276756712696888 0.33176636822335015 0.9995101214539783 0.006005343999770794 13.29873674655572 0.15192791785291773 19.92367084939502 0.05225926027337217 1.0000000000000041e-14 13.999999999999998 -3.944990344473538 VYYVDHVEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 VYYVDHVEKR 10 1 A0A590UJQ1;Q96J02-3;Q96J02-2;Q96J02;A0A590UK44;A0A590UK95 A0A590UJQ1 ITCH E3 ubiquitin-protein ligase Itchy homolog 1 6576200.0 1409300.0 2259200.0 2907700.0 True False 1364562.5429118185 3161310.3415723587 2146086.140869796 1.0 2.316720738081003 1.5727283091695428 20.38000708946272 -10.295543407138394 5.4571789076099275 0.9998648053427036 1.9447245236253055 0.6825265221590493 0.3037336372212754 0.0004996703734341017 6.450138056596608e-05 0.2941300515366211 0.09802960988673382 5.063567373324988e-11 10.295543407138394 0.9448597182826018 VYYVDHVEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYYVDHVEKR 10 1 A0A590UJQ1;Q96J02-3;Q96J02-2;Q96J02;A0A590UK44;A0A590UK95 A0A590UJQ1 ITCH E3 ubiquitin-protein ligase Itchy homolog 1 20639200.0 6194700.0 6080400.0 8364100.0 True False 9397812.793232638 4995305.1136179585 6710931.968884742 1.0 0.5315391169757154 0.7140950896273739 23.16389359850554 -10.12295387832927 5.211384923032292 1.0000101374110422 0.6228171033011637 0.8505636667347863 0.07452816375033762 8.778428948611493e-06 1.4772320531216972e-06 0.07216352301951237 0.024053861418848216 7.534355736434999e-11 10.12295387832927 -0.3771930341098785 VYYVDHVEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYYVDHVEKR 10 1 A0A590UJQ1;Q96J02-3;Q96J02-2;Q96J02;A0A590UK44;A0A590UK95 A0A590UJQ1 ITCH E3 ubiquitin-protein ligase Itchy homolog 1 7953200.0 1409300.0 4252300.0 2291600.0 True False 1171895.3925758274 4229392.0158845335 2770762.9648387535 1.0 3.6090183839602994 2.3643432531538613 20.160412364896995 -9.535156080065217 13.812646283580738 0.9999862814152725 2.9866808186014033 0.7725670954536968 0.5081364943963421 0.0 0.0 0.49200104507142084 0.16400034835714022 2.9163787152006753e-10 9.535156080065217 1.9866945371861309 VYYVSEK(ub)IMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 VYYVSEKIMK 10 1 Q9Y221;Q9Y221-2;J3QLW7 Q9Y221 NIP7 60S ribosome subunit biogenesis protein NIP7 homolog 1 19749900.0 2181400.0 2610200.0 14958300.0 True False 3309343.2817017273 2144389.416414318 12001785.448544206 1.0 0.6479803495367916 3.6266365943072123 21.65811352102944 -6.877415508490782 1.0940603191182376 0.7884367237026941 3.827584826770793 0.9715425718383407 0.2241888889808631 0.12994652410967245 0.28630090720145773 0.15819443315337361 0.3801813976793203 1.3261250888292688e-07 6.877415508490782 3.039148103068099 up VYYVSEK(ub)IMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 VYYVSEKIMK 10 1 Q9Y221;Q9Y221-2;J3QLW7 Q9Y221 NIP7 60S ribosome subunit biogenesis protein NIP7 homolog 1 5608300.0 1755600.0 2180400.0 1672300.0 True False 2404692.763306095 2084062.7183814102 1277337.1820996031 1.0 0.8666648605521372 0.531185189888231 21.197421148488132 -6.955324720833682 0.4969693375645367 1.0068987597124592 0.37655629570160004 0.99955556992124 0.004157992177603927 0.08141556808316654 0.027640094294729127 0.004904499038022351 0.02767160032523155 1.10834579815678e-07 6.955324720833682 -0.6303424640108592 VYYVSEK(ub)IMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 VYYVSEKIMK 10 1 Q9Y221;Q9Y221-2;J3QLW7 Q9Y221 NIP7 60S ribosome subunit biogenesis protein NIP7 homolog 1 6317100.0 2299300.0 2720100.0 1297700.0 True False 1911969.8262609793 2705446.281402421 1569043.0701131318 1.0 1.4150046952849424 0.8206421715250234 20.866628324940354 -6.718986599664698 1.7630883685069862 1.2527576214950096 0.8216286715179884 0.507684781248652 0.1746574219852527 0.3572843629108864 2.169974471040443 0.07867675302926423 0.1977344449992403 1.9099121887851334e-07 6.718986599664698 -0.4311289499770212 VYYVSEK(ub)IMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 VYYVSEKIMK 10 1 Q9Y221;Q9Y221-2;J3QLW7 Q9Y221 NIP7 60S ribosome subunit biogenesis protein NIP7 homolog 1 8178200.0 2181400.0 2235300.0 3761500.0 True False 2823865.301822508 2110903.5900133788 3076945.596249271 1.0 0.7475227620279948 1.0896219427546443 21.429239843121888 -6.7089750945170445 1.7986660671362322 0.844619212155062 1.0887998036073956 0.46025805033324463 0.10641009481709467 0.3771722134029462 2.3779427133338453 0.04708868125007925 0.11978490159038369 1.9544515344816806e-07 6.7089750945170445 0.24418059145233362 WAAVVVPSGEEQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WAAVVVPSGEEQR 13 0 A0A1W2PNZ7;Q31611;A0A0G2JNX1;P17693-6;P17693-2;O78179;A0A140T912;A0A1W2PRZ0;A0A140T930;A0A140T937;A0A140T9B7;A0A0G2JH66;D0EV57;A0A0G2JPA3;A0A140T8X0;A0A140T9V0;A0A140T9W7;A0A140T9W3;A0A140T9C2;A0A140T939;A0A140T9D9;A0A140T9X6;Q53YP1;A0A140T9M0;A0A140T9W2;A0A140T9U0;Q5QT33;A0A140T9J9;A0A1W2PRX1;A0A1W2PR11;A0A140T962;A0A140T9B3;A0A1W2PP77;A0A1W2PS56;D9J307;Q2L6G2;D5H3J5;A0A140T9G0;A0A140T9H3;A0A140T9A9;Q5SRN5;P04439;P04439-2;A0A1W2PS24;Q5SRN7;Q5SUL5;A0A0G2JIF2;A0A0G2JL56;A0A0G2JI36;A0A1W2PQD0;A0A1W2PSE7;P01889;A0A1W2PPR8;P01893;P13747;Q8MH48;Q5RJ85;A0A0G2JPQ3;P17693-5;P17693 A0A1W2PNZ7;O78179;Q53YP1;Q5QT33;D9J307;Q5SRN5;P01889;P01893;P13747;Q8MH48 HLA-G2.2;HLA-G;HLA-C;HLA-F;HLA-B;HLA-A;HLA-H;HLA-E HLA class I histocompatibility antigen, alpha chain G;HLA class I histocompatibility antigen, A-3 alpha chain;HLA class I histocompatibility antigen, B-7 alpha chain;Putative HLA class I histocompatibility antigen, alpha chain H;HLA class I histocompatibility antigen, alpha chain E 0 13843500.0 1852400.0 5680700.0 6310400.0 False True 2428514.3386671157 4833161.7031951705 5657460.341631087 1.0 1.9901721913850587 2.3295972568711165 21.21164257380929 -10.259030913655918 0.243946169788034 5.38535782302387e-19 2.5223232939760662 0.9991557351117243 0.01638947716218366 1.8056177880966202 0.11634886455621454 1.3180788779437351 0.15832017354065928 5.507684905800744e-11 10.259030913655918 2.5223232939760662 WAAVVVPSGEEQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WAAVVVPSGEEQR 13 0 A0A1W2PNZ7;Q31611;A0A0G2JNX1;P17693-6;P17693-2;O78179;A0A140T912;A0A1W2PRZ0;A0A140T930;A0A140T937;A0A140T9B7;A0A0G2JH66;D0EV57;A0A0G2JPA3;A0A140T8X0;A0A140T9V0;A0A140T9W7;A0A140T9W3;A0A140T9C2;A0A140T939;A0A140T9D9;A0A140T9X6;Q53YP1;A0A140T9M0;A0A140T9W2;A0A140T9U0;Q5QT33;A0A140T9J9;A0A1W2PRX1;A0A1W2PR11;A0A140T962;A0A140T9B3;A0A1W2PP77;A0A1W2PS56;D9J307;Q2L6G2;D5H3J5;A0A140T9G0;A0A140T9H3;A0A140T9A9;Q5SRN5;P04439;P04439-2;A0A1W2PS24;Q5SRN7;Q5SUL5;A0A0G2JIF2;A0A0G2JL56;A0A0G2JI36;A0A1W2PQD0;A0A1W2PSE7;P01889;A0A1W2PPR8;P01893;P13747;Q8MH48;Q5RJ85;A0A0G2JPQ3;P17693-5;P17693 A0A1W2PNZ7;O78179;Q53YP1;Q5QT33;D9J307;Q5SRN5;P01889;P01893;P13747;Q8MH48 HLA-G2.2;HLA-G;HLA-C;HLA-F;HLA-B;HLA-A;HLA-H;HLA-E HLA class I histocompatibility antigen, alpha chain G;HLA class I histocompatibility antigen, A-3 alpha chain;HLA class I histocompatibility antigen, B-7 alpha chain;Putative HLA class I histocompatibility antigen, alpha chain H;HLA class I histocompatibility antigen, alpha chain E 0 6277900.0 1741200.0 1122400.0 3414300.0 False True 1685926.5590846934 1570580.1732386765 2519992.4031955656 1.0 0.9315827933165489 1.4947225249026832 20.68511026150453 -6.876525594761318 1.0990332026539533 0.9592678247579537 1.532059272686995 0.9707713364372146 0.042894861896685475 0.1307502844551132 0.29128569927699016 0.030154240844604382 0.07231656578538397 1.3288452404995404e-07 6.876525594761318 0.5727914479290414 WAAVVVPSGEEQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WAAVVVPSGEEQR 13 0 A0A1W2PNZ7;Q31611;A0A0G2JNX1;P17693-6;P17693-2;O78179;A0A140T912;A0A1W2PRZ0;A0A140T930;A0A140T937;A0A140T9B7;A0A0G2JH66;D0EV57;A0A0G2JPA3;A0A140T8X0;A0A140T9V0;A0A140T9W7;A0A140T9W3;A0A140T9C2;A0A140T939;A0A140T9D9;A0A140T9X6;Q53YP1;A0A140T9M0;A0A140T9W2;A0A140T9U0;Q5QT33;A0A140T9J9;A0A1W2PRX1;A0A1W2PR11;A0A140T962;A0A140T9B3;A0A1W2PP77;A0A1W2PS56;D9J307;Q2L6G2;D5H3J5;A0A140T9G0;A0A140T9H3;A0A140T9A9;Q5SRN5;P04439;P04439-2;A0A1W2PS24;Q5SRN7;Q5SUL5;A0A0G2JIF2;A0A0G2JL56;A0A0G2JI36;A0A1W2PQD0;A0A1W2PSE7;P01889;A0A1W2PPR8;P01893;P13747;Q8MH48;Q5RJ85;A0A0G2JPQ3;P17693-5;P17693 A0A1W2PNZ7;O78179;Q53YP1;Q5QT33;D9J307;Q5SRN5;P01889;P01893;P13747;Q8MH48 HLA-G2.2;HLA-G;HLA-C;HLA-F;HLA-B;HLA-A;HLA-H;HLA-E HLA class I histocompatibility antigen, alpha chain G;HLA class I histocompatibility antigen, A-3 alpha chain;HLA class I histocompatibility antigen, B-7 alpha chain;Putative HLA class I histocompatibility antigen, alpha chain H;HLA class I histocompatibility antigen, alpha chain E 0 10141800.0 1852400.0 3416500.0 4872900.0 False True 2537282.339227731 3265547.7331453315 3722021.3805257184 1.0 1.2870257608537417 1.4669322853752984 21.27485263533218 -9.849461872111053 0.07498189098272624 1.728481901946727e-15 2.2201233896543933 0.9999773303053691 0.000915522202713258 1.4285531685648023 0.0339542012823542 0.6403730404798279 0.37278806498567074 1.4142888838719771e-10 9.849461872111053 2.2201233896543915 WAEYHADIYDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WAEYHADIYDK 11 0 Q9NRX4;Q9NRX4-2 Q9NRX4 PHPT1 14 kDa phosphohistidine phosphatase 0 6718100.0 1579200.0 2475800.0 2663100.0 False True 2070346.4929945546 2106420.290592814 2387547.9582590265 1.0 1.017424038787866 1.1532117770323898 20.981440806561995 -6.930585980288385 0.7419590722988215 0.9979793902611828 1.1815095929427584 0.996652313345281 0.003962670573512326 0.09233445996444661 0.07619581224056948 0.0036228644683552846 0.012247069654011419 1.1733133705164354e-07 6.930585980288385 0.1835302026815756 WAEYHADIYDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WAEYHADIYDK 11 0 Q9NRX4;Q9NRX4-2 Q9NRX4 PHPT1 14 kDa phosphohistidine phosphatase 0 6228700.0 1579200.0 2710400.0 1939100.0 False True 2163072.9162753383 2590645.565905781 1481124.5170180856 1.0 1.1976690875343643 0.6847316638629453 21.044650868084886 -6.802230519818167 1.4467905535373533 1.1087567067961703 0.6772552398524669 0.8385999851651326 0.08486179961275478 0.217591844560364 0.8989514807556163 0.046138850126507695 0.10715941209482686 1.5767741092503774e-07 6.802230519818167 -0.4315014669437034 WAEYHADIYDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WAEYHADIYDK 11 0 Q9NRX4;Q9NRX4-2 Q9NRX4 PHPT1 14 kDa phosphohistidine phosphatase 0 2757660.0 1291000.0 910510.0 556150.0 False True 1073523.7009972264 905604.9019079157 672438.3936529381 1.0 0.8435816564335504 0.6263843015559797 20.033922612345457 -6.966508850864273 0.33114670229072385 1.0261102476137918 0.436733375311452 0.9999409435977415 0.0011772939097579504 0.07745272988370448 0.013075146941365207 0.0031564343428778533 0.018927012481955795 1.080167606984176e-07 6.966508850864273 -0.5893768723023398 WAFSCGTWLPSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WAFSCGTWLPSR 12 0 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 16571600.0 5219100.0 6594600.0 4757900.0 False True 6842290.641836294 5610711.38554946 4265598.148999516 1.0 0.8200048316047109 0.623416684891763 22.7060479564803 -6.969995294341932 0.25831414192592406 1.0563407921630883 0.38126116769196916 0.9999823396039428 0.0006462622977327578 0.0763043563873796 0.009036364363324704 0.004148945568137064 0.018595671102663636 1.0715309154030365e-07 6.969995294341932 -0.6750796244711191 WAFSCGTWLPSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WAFSCGTWLPSR 12 0 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 9268200.0 6107000.0 1523000.0 1638200.0 False True 5913136.627802794 2131141.842340081 1209106.2750534455 1.0 0.3604080163342973 0.20447798709205978 22.495492181447243 -13.999999999999998 0.1982416899057305 4.531894408992919 0.10143726994631032 0.9994869415329354 0.007796344815899761 12.496684172886448 0.1411860411111892 17.101577422437888 0.10060576242020582 1.0000000000000041e-14 13.999999999999998 -4.4304571390466085 WAFSCGTWLPSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WAFSCGTWLPSR 12 0 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 16478500.0 4267500.0 5465600.0 6745400.0 False True 6474109.496040202 4490220.977072285 5412168.733386156 1.0 0.6935658069760274 0.8359711457917778 22.626250335250983 -10.059347775053144 4.627354400034448 1.000010173855097 0.7647684763751881 0.7843954842432126 0.058136736153048825 80610617.97629727 1.5773849596303893 8968.186830790955 0.01990175112743567 8.72272588754934e-11 10.059347775053144 -0.23524169747990897 WAFSCGTWLPSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WAFSCGTWLPSR 12 0 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 21457200.0 5219100.0 7405500.0 8832600.0 False True 7148742.310874249 7078300.523286333 6746521.793107067 1.0 0.9901462684588919 0.9437354851698393 22.769258018003192 -6.941147611030843 0.6488094068248553 1.0005123790944532 0.930786249523905 0.9983102176299055 0.0010084549963392234 0.08724711729621755 0.052256602744803114 0.0009904056877173824 0.00397472228579641 1.1451236626942993e-07 6.941147611030843 -0.06972612957054825 WAFSCGTWLPSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WAFSCGTWLPSR 12 0 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 11537700.0 6107000.0 1641700.0 3789000.0 False True 5078241.085972171 1632855.8362480628 4581262.381643404 1.0 0.32153964504729127 0.90213566155778 22.27589745688152 -10.425623230364733 8.54341184197121 1.0000048070219953 0.6118376533026043 0.37341805839816167 0.23702733119053582 2.170259590835336e-05 1.459086768326308e-06 0.22950356641266142 0.07650024219141129 3.752984490276748e-11 10.425623230364733 -0.38816715371939103 WAFSCGTWLPSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WAFSCGTWLPSR 12 0 Q9NRN7;Q9NRN7-2 Q9NRN7 AASDHPPT L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0 30348500.0 4267500.0 15352000.0 10729000.0 False True 5524362.87500116 14497647.7045074 8776432.088836474 1.0 2.6243112613242943 1.5886776968528937 22.397376657343433 -10.496317327330928 5.033479685059139 0.996773937698921 2.1064944790886293 0.6034949980847557 0.42279563224256944 0.015329396742851968 0.0015339570937971045 0.4099849442465437 0.1364567035437079 3.189206735728274e-11 10.496317327330928 1.1097205413897084 WAGIAK(ub)GVGTQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WAGIAKGVGTQK 12 1 Q5TDH0;Q5TDH0-3 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 140625000.0 15954000.0 92050000.0 32621000.0 True False 20915848.498755775 78316498.8080898 29245691.842727523 1.0 3.7443615453969565 1.3982551004071035 24.318093189571783 -6.60798780976921 2.1615653102083905 2.8360032509714532 1.4065572780448639 0.044111639392404034 1.1837942188595296 0.6181615498971049 5.470411609752261 0.4527640144222892 1.3143789286772378 2.4661085575717227e-07 6.60798780976921 -1.4294459729265894 WAGIAK(ub)GVGTQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WAGIAKGVGTQK 12 1 Q5TDH0;Q5TDH0-3 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 225667300.0 73351000.0 77491300.0 74825000.0 True False 71022512.6553075 108433980.2017909 55226087.798116244 1.0 1.5267550548099011 0.7775856659161609 26.081773065562082 -6.7177596181677535 1.7674802615132958 1.3212410942113246 0.7789076246474108 0.5018493567717435 0.22172413068467378 0.3597030790322281 2.1948786667028037 0.09965589147794546 0.2508254067561582 1.9153157582365628e-07 6.7177596181677535 -0.5423334695639138 WAGIAK(ub)GVGTQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WAGIAKGVGTQK 12 1 Q5TDH0;Q5TDH0-3 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 127345000.0 52113000.0 25622000.0 49610000.0 True False 79059230.97062528 21049553.91440027 39804561.75516459 1.0 0.26625042586388553 0.5034777250736743 26.236430585973398 -10.17191760225891 5.303933073791181 1.000024938910339 0.38486407546955237 0.8996490397119101 0.09684763935451451 2.8561745492609345e-05 4.459237410783102e-06 0.09377611544205616 0.031257441194851854 6.731043507849339e-11 10.17191760225891 -0.6151608634407867 WAGIAK(ub)GVGTQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WAGIAKGVGTQK 12 1 Q5TDH0;Q5TDH0-3 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 67007000.0 15954000.0 22369000.0 28684000.0 True False 21852624.94063877 21380663.615608938 21909429.965523526 1.0 0.9784025339604792 1.002599460020893 24.381303251094675 -6.671273727340016 1.9323850698891685 0.9862301881754459 1.0025033237589742 0.28495329206789277 0.009171326829623372 0.45816977737402886 3.2994456473036564 0.0038188236051693906 0.010187790282405575 2.13170092013862e-07 6.671273727340016 0.016273135583528275 WAGIAK(ub)GVGTQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WAGIAKGVGTQK 12 1 Q5TDH0;Q5TDH0-3 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 251832800.0 73351000.0 169541000.0 8940800.0 True False 60994606.500269346 168627648.98174638 10810279.94241155 1.0 2.764632131547594 0.17723337459950353 25.86217834099636 -6.723150654392088 1.7483359212442493 2.0700269438410612 0.18068240947333347 0.5270536165205194 0.7422998124696392 0.349302689115776 2.088355835950595 0.3369239048464406 0.842572743212874 1.8916872887881178e-07 6.723150654392088 -1.8893445343677278 WAGIAK(ub)GVGTQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WAGIAKGVGTQK 12 1 Q5TDH0;Q5TDH0-3 Q5TDH0 DDI2 Protein DDI1 homolog 2 1 146020000.0 52113000.0 64000000.0 29907000.0 True False 67461305.8008051 60438343.73947853 24464232.871733826 1.0 0.895896440515642 0.36264096256852857 26.007556908065848 -6.93926816250744 0.666345087248729 1.006067939811995 0.2218866303511448 0.998066351233399 0.012276039220671185 0.08810232133990922 0.056143749029617926 0.011884477266085134 0.04604628137805294 1.1500900270248201e-07 6.93926816250744 -0.7841813094608501 down WAIAQLNYADMLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WAIAQLNYADMLK 13 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y6H2;A0A2R8YFZ7;H0YJ21 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 3645040.0 983240.0 1634400.0 1027400.0 False True 1289037.1617097047 1390553.890841303 921094.5035167002 1.0 1.0787539197062033 0.7145600847496232 20.297862425142814 -6.850098577952138 1.2346192570424828 1.0420292112878735 0.6999736320588185 0.9404488364454452 0.03818090078623506 0.15734805230375146 0.46149029923669643 0.024198449476880508 0.056000049006753976 1.412216957412336e-07 6.850098577952138 -0.34205557922905505 WAIAQLNYADMLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WAIAQLNYADMLK 13 0 Q14204;A0A2R8Y706;A0A2R8Y5T0;A0A2R8Y6H2;A0A2R8YFZ7;H0YJ21 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 5672640.0 983240.0 1391900.0 3297500.0 False True 1346770.399061907 1330401.2556022224 2518698.414144259 1.0 0.9878456316896431 1.8701765467214444 20.361072486665705 -6.903778642953177 0.937078425334123 0.9670208162000195 1.9702372166761113 0.9883538916953999 0.04458054402764113 0.10867727760659283 0.16215256331864658 0.03541117995514537 0.09400854979830031 1.2480194594874228e-07 6.903778642953177 1.003216400476092 WALHILAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WALHILAR 8 0 O95373 O95373 IPO7 Importin-7 0 9949700.0 2597700.0 3951900.0 3400100.0 False True 3405609.856162582 3362291.9243855495 3048290.268062224 1.0 0.9872804186014886 0.8950791185156531 21.699481739860726 -6.9319819151858715 0.7303716834358952 1.001304211524434 0.875160579534918 0.9969130752381417 0.002597507287931206 0.09162222860849514 0.07274209302721284 0.002394960371523012 0.008253624550470235 1.1695480921209982e-07 6.9319819151858715 -0.12614363198951595 WALHILAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WALHILAR 8 0 O95373 O95373 IPO7 Importin-7 0 8393000.0 3393600.0 2086500.0 2912900.0 False True 3285872.0255627213 2919650.3309537615 2149924.1048731403 1.0 0.8885465740114323 0.654293316400524 21.647844862247183 -6.959062202923956 0.4484548421676372 1.0076746242045902 0.5259026571675748 0.9997338197553828 0.0023505251432535427 0.08003783612951265 0.022382038532656308 0.0031239263901409187 0.019381147414347714 1.0988484428177256e-07 6.959062202923956 -0.4817719670370154 WALHILAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WALHILAR 8 0 O95373 O95373 IPO7 Importin-7 0 18333800.0 2597700.0 6557100.0 9179000.0 False True 3558139.8902029134 6267385.6405699635 7011109.247439006 1.0 1.7614219322367755 1.9704422714642558 21.762691801383617 -10.888535691038877 0.2535077640474991 2.8565260928092526e-14 2.069782684102076 0.9992115458343701 0.011709905034353374 2.7631339306733995 0.13250094280187671 1.7353247108575098 0.09371777699592325 1.2926004683970996e-11 10.888535691038877 2.0697826841020475 WALHILAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WALHILAR 8 0 O95373 O95373 IPO7 Importin-7 0 9309800.0 3393600.0 2668000.0 3248200.0 False True 2821928.7619707123 2653626.954443467 3927383.6020200932 1.0 0.9403592997118358 1.391737330490717 21.42825013768146 -6.87362163443783 1.1147097924999723 0.9654018538030205 1.4200632874385217 0.9681683330024913 0.03572037262302256 0.1334322809326176 0.30768047302092955 0.024809557392199744 0.059138427624709326 1.3377604912266235e-07 6.87362163443783 0.45466143363550127 WALHILAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WALHILAR 8 0 O95373 O95373 IPO7 Importin-7 0 50805000.0 16556000.0 19570000.0 14679000.0 False True 21432068.367549922 18480912.296587408 12007572.619259069 1.0 0.8623018543823409 0.5602619594774909 24.353267752658624 -6.958199257411236 0.46010997351864935 1.0087942606920774 0.40159149404491706 0.9996974712765458 0.0031943499060822634 0.0803507609599869 0.023556319164257603 0.004102810517368711 0.024951232395554374 1.1010340313574249e-07 6.958199257411236 -0.6072027666471604 WALSQSNPSALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WALSQSNPSALR 12 0 P55072 P55072 VCP Transitional endoplasmic reticulum ATPase 0 18186100.0 2819800.0 7210100.0 8156200.0 False True 3696785.1069820435 6134381.184749681 7312274.663794917 1.0 1.659382681769573 1.978009122029942 21.81783975185339 -10.156869326724411 0.16416756329676144 1.418076359347247e-17 2.3786805469925203 0.999633440374153 0.007797461398152415 1.7764018902194187 0.07926090828461092 1.0073205970975674 0.25175834066820935 6.968361510473179e-11 10.156869326724411 2.3786805469925203 WALSSLLQQLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WALSSLLQQLLK 12 0 Q6UWE0;Q6UWE0-2;Q6UWE0-3 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 0 2213950000.0 860980000.0 783870000.0 569100000.0 False True 1306169606.0692894 643982274.0957364 456617135.5546093 1.0 0.49303112788981446 0.3495848727706398 30.282695096925657 -13.999999999999998 0.1770841952400437 3.607516009510621 0.23214103085995774 0.9995019458599692 0.006226764951558929 12.168388105324883 0.133370540651349 10.910487648685464 0.1098162685501784 1.0000000000000041e-14 13.999999999999998 -3.3753749786506635 WALSSLLQQLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WALSSLLQQLLK 12 0 Q6UWE0;Q6UWE0-2;Q6UWE0-3 Q6UWE0 LRSAM1 E3 ubiquitin-protein ligase LRSAM1 0 1908260000.0 860980000.0 508650000.0 538630000.0 False True 1114555582.4530754 480343180.3607154 440604866.81051254 1.0 0.43097283609984394 0.39531888202539484 30.053821419018107 -13.97220770783785 0.3939901968302233 9.999999999844958 0.39290198005410204 0.9998286087722484 0.00362675287308908 25.29947473317315 0.20601720089383985 194.04228703652873 0.00928131142920052 1.0660861276328872e-14 13.97220770783785 -9.607098019790856 WALWFFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WALWFFK 7 0 P06730;P06730-2;D6RBW1;P06730-3;H0Y8J7;D6RHE2;H0Y8X3;A6NMX2 P06730 EIF4E;EIF4E1B Eukaryotic translation initiation factor 4E;Eukaryotic translation initiation factor 4E type 1B 0 153627000.0 57016000.0 47254000.0 49357000.0 False True 86497440.4279388 38821154.50281284 39601567.316058375 1.0 0.448812754582661 0.4578351350066887 26.366154106364892 -10.244005454533479 5.538403843160323 1.0000355407800832 0.4533239447946516 0.999795752954003 0.0036833713841071926 1.6165401339628178e-06 2.2066707182362728e-07 0.003566640080973115 0.001188803002366593 5.701571113318721e-11 10.244005454533479 -0.5467115959854316 WALWFFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WALWFFK 7 0 P06730;P06730-2;D6RBW1;P06730-3;H0Y8J7;D6RHE2;H0Y8X3;A6NMX2 P06730 EIF4E;EIF4E1B Eukaryotic translation initiation factor 4E;Eukaryotic translation initiation factor 4E type 1B 0 151174000.0 57016000.0 47231000.0 46927000.0 False True 73808335.95338413 44602553.33061419 38386767.51168132 1.0 0.6043023833891102 0.5200871556828708 26.13728042845734 -13.999999999999998 0.2174634409651486 3.361601471527549 0.4739305809126829 0.9994954815935284 0.004699556225407881 12.93191848719487 0.14775101014545294 13.097524694922509 0.047399222812378225 1.0000000000000041e-14 13.999999999999998 -2.887670890614866 WANFHLENSGWQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WANFHLENSGWQK 13 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 76304000.0 20155000.0 22666000.0 33483000.0 False True 26423400.18129763 19284321.151376013 30018500.35161536 1.0 0.7298198195183591 1.1360574394533194 24.6553127897314 -6.727429287664187 1.7326701884370428 0.8369399060823293 1.1357006312311584 0.5472418656249611 0.11360244924796378 0.3410967430762943 2.004956300453904 0.051983880241114576 0.12936829644908623 1.8731420453697416e-07 6.727429287664187 0.2987607251488291 WANFHLENSGWQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WANFHLENSGWQK 13 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 72701000.0 20956000.0 10684000.0 41061000.0 False True 20290763.25073446 14950176.916323973 30305892.296404287 1.0 0.7367971688193062 1.4935806959014868 24.27431979827305 -6.812746959309254 1.402805404075275 0.8570166350812206 1.507689664575854 0.8669261032190332 0.11443230081325935 0.20306926877472167 0.7870404296831143 0.06413059805999384 0.1481817785475727 1.5390511037367846e-07 6.812746959309254 0.6506730294946333 WANFHLENSGWQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WANFHLENSGWQK 13 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 63101000.0 20155000.0 21025000.0 21921000.0 False True 27606848.16839502 20096045.97962258 16743711.277166417 1.0 0.7279369907438045 0.6065057182563498 24.718522851254292 -13.999999999999934 0.10915826769404367 2.314714558258368 0.3810207813200484 0.9997473387118228 0.0026150927383227114 12.017637489130287 0.10011845707662946 3.487679340385873 0.20032135642000165 1.0000000000001513e-14 13.999999999999934 -1.9336937769383196 WANFHLENSGWQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WANFHLENSGWQK 13 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 45883200.0 20956000.0 16188000.0 8739200.0 False True 17425842.508209072 16100792.030933566 10566526.314504636 1.0 0.923960607548743 0.6063710440127582 24.054725073707328 -6.943883530082878 0.6223933868502284 1.0034709051997561 0.5099664056562379 0.9986295203032098 0.0063113825091485635 0.08603894908322972 0.04687251112428163 0.006342231657872249 0.026902119450053275 1.137932417778292e-07 6.943883530082878 -0.49350449954351827 WANFHLENSGWQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WANFHLENSGWQK 13 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 48056000.0 13280000.0 23063000.0 11713000.0 False True 17191221.787935667 21779523.775993623 9581354.185529104 1.0 1.266897957844852 0.5573399205548635 24.03516874566262 -6.804786948113236 1.4361019772216388 1.1463769466977982 0.5463252612351709 0.8458491404249431 0.11488987087040271 0.2139876681393166 0.8706878605277033 0.06292022522717983 0.14593629839801509 1.5675198598921547e-07 6.804786948113236 -0.6000516854626273 WANYHLENAGCNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WANYHLENAGCNK 13 0 P13796 P13796 LCP1 Plastin-2 0 26795800.0 3451300.0 13841800.0 9502700.0 False True 4524687.722436748 11776657.394913811 8519451.760334965 1.0 2.602755840257535 1.882881710949735 22.10938679536793 -10.077349516830013 4.873245652022853 0.9999603630394122 2.2428187756146993 0.7989595021025485 0.2938873826772577 0.00012656681005111797 2.3963164888336885e-05 0.28456425494571447 0.09485174489201789 8.36855516214883e-11 10.077349516830013 1.2428584125752873 WANYHLENAGCNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WANYHLENAGCNK 13 0 P13796 P13796 LCP1 Plastin-2 0 80668800.0 4014100.0 72944700.0 3710000.0 False True 6089683.170018751 59927148.36545751 2976716.873849235 1.0 9.840766209397556 0.4888130943337844 22.537935739831298 -6.658898112484559 1.977035844094223 6.695974081042489 0.5281087434731476 0.2308164135515296 3.7652176885752913 0.48707605482970684 3.658726520088045 1.5393698863968102 4.172817193179414 2.1933194379879283e-07 6.658898112484559 -6.167865337569341 WANYHLENAGCNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WANYHLENAGCNK 13 0 P13796 P13796 LCP1 Plastin-2 0 24463500.0 3451300.0 9449200.0 11563000.0 False True 4727338.877875559 9031703.099674203 8832057.54746021 1.0 1.910525844031093 1.8682937220335871 22.17259685689082 -10.350389063856586 5.612284618998029 0.9997989516853615 1.8894097830323466 0.9983118557895471 0.017241191608166485 4.338149216820267e-05 5.021309162389914e-06 0.016697371301167566 0.005564570663929921 4.4628360866717935e-11 10.350389063856586 0.8896108313469852 WAPNENK(ub)FAVGSGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WAPNENKFAVGSGSR 15 1 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 1 4358400.0 1168800.0 1465600.0 1724000.0 True False 1532308.1186753006 1246938.1928640553 1545617.017775734 1.0 0.8137646584696352 1.008685524104603 20.547274994909095 -11.14036472206876 10.38331326822166 3.5453125299631063 0.9112250912871165 0.21664988069555835 0.079576110171212 0.039450698045119324 0.0005333072625139508 0.0006482801275232144 0.025683079120755892 7.23827831538762e-12 11.14036472206876 -2.63408743867599 WAPNENK(ub)FAVGSGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WAPNENKFAVGSGSR 15 1 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 1 6979300.0 1476400.0 1791300.0 3711600.0 True False 1429532.4901405007 2506575.431506093 2739420.614386746 1.0 1.7534231986988529 1.916305248940165 20.447111978962237 -11.047533232976127 0.2875033536792804 1.5463920254395215e-14 1.9707830639732518 0.9992430163204019 0.010981586293892683 2.989268531867507 0.14924274066502025 2.0269484892291594 0.061922039491893364 8.963275947646367e-12 11.047533232976127 1.9707830639732362 WAPNENK(ub)FAVGSGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WAPNENKFAVGSGSR 15 1 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 1 6492400.0 1168800.0 1590800.0 3732800.0 True False 1600936.9456323548 1520513.195927878 2851189.5194291696 1.0 0.9497645738491529 1.780950540998963 20.610485056431987 -6.892527886560182 1.007281125071609 0.9580081945302586 1.8560915063348031 0.9824684957675905 0.05038563945286626 0.11711717664251399 0.21004564309426976 0.03798077632731141 0.09559296129962727 1.2807728519625803e-07 6.892527886560182 0.8980833118045445 WAPNENK(ub)FAVGSGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WAPNENKFAVGSGSR 15 1 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 1 7275700.0 1476400.0 1628200.0 4171100.0 True False 1227692.0156098425 1619428.5634276061 5043257.725012622 1.0 1.3190837301513059 4.107917670628035 20.227517254396513 -6.9284882169166675 0.7591010203470795 0.9551265667988368 4.659011557485227 0.9962326676252803 0.08568261197355857 0.09343039721321071 0.08158235013897569 0.07737029900433942 0.2544712798463695 1.1789945107607609e-07 6.9284882169166675 3.7038849906863907 up WAPNENK(ub)FAVGSGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WAPNENKFAVGSGSR 15 1 A0A1W2PNV4;O15143;C9JEY1;C9K057;F8VXW2 A0A1W2PNV4;O15143 ARPC1B Actin-related protein 2/3 complex subunit 1B 1 35843000.0 1944800.0 6857200.0 27041000.0 True False 2517581.9377392535 6475590.792036749 22119815.464090534 1.0 2.5721469855522248 8.786135272305678 21.2636073025697 -6.94514888364541 0.609782878382728 0.9312448825336955 10.750521881810636 0.9987634838262929 0.11821123717096077 0.08549418864782359 0.04448898085052268 0.12018371093406531 0.5239395083668914 1.1346217810592662e-07 6.94514888364541 9.81927699927694 WAQFFIHPLMIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WAQFFIHPLMIR 12 0 O43847-2;G3V1R5;O43847;F5H7V1 O43847-2 NRD1 Nardilysin 0 21898300.0 4791200.0 6655100.0 10452000.0 False True 7268600.683638627 5467445.408466371 8386157.618725659 1.0 0.752200546767331 1.1537513179947572 22.79324621942691 -6.7397617247232295 1.6875118481258373 0.8525187614095914 1.1539766414622896 0.6038749115467724 0.10411557825784261 0.3182585751751313 1.779433291569442 0.048810153420955876 0.11980971056671418 1.8206995097783944e-07 6.7397617247232295 0.30145788005269825 WAQFFIHPLMIR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 WAQFFIHPLMIR 12 0 O43847-2;G3V1R5;O43847;F5H7V1 O43847-2 NRD1 Nardilysin 0 30846100.0 8158000.0 13235800.0 9452300.0 False True 10560691.818221327 12499216.094796725 7732078.388788246 1.0 1.1835603490701891 0.7321564270484046 23.332201011220857 -6.7963085121016364 1.4708464958876786 1.1017611961999993 0.7264738100017646 0.8211401121834342 0.07838898148045906 0.22609188095528918 0.9659760894796178 0.04193371786395344 0.09775372145032818 1.5984221454937365e-07 6.7963085121016364 -0.37528738619823476 WARPPISMNFEVPFAPSGLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WARPPISMNFEVPFAPSGLK 20 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2 E9PFW3 AP2M1 AP-2 complex subunit mu 0 4619300.0 1596500.0 1926400.0 1096400.0 False True 2093026.9605279947 1638988.629048385 982955.0454114361 1.0 0.7830709589306617 0.46963324598717654 20.997159464563055 -6.965872199655713 0.34275926609525825 1.0329283294317082 0.20931584978119377 0.9999300055500946 0.0018214357456762917 0.0776662925256946 0.013823607876608367 0.0043882921924419645 0.027075330619558472 1.0817522329577664e-07 6.965872199655713 -0.8236124796505144 down WARPPISMNFEVPFAPSGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WARPPISMNFEVPFAPSGLK 20 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2 E9PFW3 AP2M1 AP-2 complex subunit mu 0 26399200.0 10417000.0 6627800.0 9354400.0 False True 10086318.036977507 9274315.103520397 6904202.014015348 1.0 0.9194946133484765 0.6845116313707157 23.265896285709672 -6.952065394750311 0.5356878806223362 1.0035611318220432 0.5896734165990615 0.9993535662770023 0.003403019493786083 0.08266680587619836 0.032610700334624106 0.0037655035344026986 0.019447092302509558 1.1166950865496584e-07 6.952065394750311 -0.41388771522298173 WARPPISMNFEVPFAPSGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WARPPISMNFEVPFAPSGLK 20 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2 E9PFW3 AP2M1 AP-2 complex subunit mu 0 24696500.0 5860500.0 8574000.0 10262000.0 False True 8890806.959939923 7043902.711032245 8233711.202005611 1.0 0.7922680970097052 0.9260926751761628 23.083882938240713 -10.71535019829389 5.384455263263131 1.0041302755483805 0.8591803860929341 0.5961820432147485 0.054633655258504034 0.0027810999537338415 0.00014702296193946438 0.05430998832290912 0.017632936413218604 1.925971258047028e-11 10.71535019829389 -0.1449498894554464 WARPPISMNFEVPFAPSGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 WARPPISMNFEVPFAPSGLK 20 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2 E9PFW3 AP2M1 AP-2 complex subunit mu 0 14178570.0 1986670.0 3065200.0 9126700.0 False True 2721195.5867380486 2929769.3287390806 6971161.430286702 1.0 1.0766478319373778 2.5618009467093 21.37580922377145 -6.917599246667068 0.8423374642066495 0.9643106294902303 2.788554220740153 0.9934876938535305 0.058010805931698155 0.09960511951906828 0.11308493597568062 0.049356944680056254 0.14461898191358255 1.2089288822354527e-07 6.917599246667068 1.8242435912499224 up WARPPISMNFEVPFAPSGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WARPPISMNFEVPFAPSGLK 20 1 E9PFW3;Q96CW1;A0A087WY71;Q96CW1-2 E9PFW3 AP2M1 AP-2 complex subunit mu 0 24601200.0 10417000.0 5811900.0 8372300.0 False True 8662197.051346332 5780590.141128168 10122909.220858563 1.0 0.6673353315403641 1.168630678897474 23.04630156114395 -6.7277982982977775 1.7313634983597896 0.7993140453862281 1.1682089799691662 0.5489933093342951 0.13987002368585966 0.34037538176270526 1.9978818675352386 0.06404823657852378 0.15932264371264526 1.8715511530326393e-07 6.7277982982977775 0.3688949345829381 WASSLHGSLFPHLSLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WASSLHGSLFPHLSLR 16 0 Q9NRG9-2;Q9NRG9 Q9NRG9-2 AAAS Aladin 0 28329500.0 7424700.0 8063800.0 12841000.0 False True 11263812.718277602 6624751.887243035 10302970.72158977 1.0 0.5881447120026384 0.9146965578423824 23.425191916025028 -9.869749510477586 6.374774155214119 1.000000015501491 0.7514206349224763 0.4358625355343335 0.13331423281201663 2.9330042225360758e-08 5.129398452317605e-09 0.12908095856710344 0.04302698362442857 1.349741152975499e-10 9.869749510477586 -0.24857938057901463 WASSLHGSLFPHLSLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WASSLHGSLFPHLSLR 16 0 Q9NRG9-2;Q9NRG9 Q9NRG9-2 AAAS Aladin 0 6626900.0 1389700.0 2726500.0 2510700.0 False True 1155597.1241486038 2711811.8033321253 3035675.7618348105 1.0 2.3466757978738277 2.6269326034117393 20.140207088012488 -10.341226334058813 0.3420194357236347 3.214639903413452e-15 2.6859690397517295 0.9990408174244415 0.02199423946319444 1.7963383519016243 0.16042723794715058 1.7104009076629128 0.08535187787920274 4.557993126676661e-11 10.341226334058813 2.6859690397517264 WASSLHGSLFPHLSLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WASSLHGSLFPHLSLR 16 0 Q9NRG9-2;Q9NRG9 Q9NRG9-2 AAAS Aladin 0 24801800.0 7424700.0 7876100.0 9501000.0 False True 9611420.512717307 7437788.111351673 7771915.488492446 1.0 0.773848995734855 0.8086125748227405 23.196318238117478 -10.340476781429672 4.9790663219938605 1.0001086066983895 0.7912307852787431 0.9796277744592174 0.014192171733223975 1.7119073452045583e-05 2.2676052839547043e-06 0.013748638315789511 0.004580503730747261 4.5658665992083474e-11 10.340476781429672 -0.2088778214196464 WCDCK(ub)LPNSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WCDCKLPNSK 10 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 6642300.0 3251700.0 1675800.0 1714800.0 True False 3148476.5633905935 2344955.6791815534 1265642.4371027006 1.0 0.7447905779092957 0.4019856624690039 21.586222497591386 -6.967026839475955 0.32137411397025184 1.046196455326275 0.08950044220743937 0.9999490329438854 0.0017491451893802154 0.07727977154733057 0.012469676664330048 0.0051676348430023675 0.030117488745424373 1.0788800451915121e-07 6.967026839475955 -0.9566960131188357 down WCDCK(ub)LPNSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WCDCKLPNSK 10 1 Q13148;A0A087WYY0;A0A087X260;G3V162;B1AKP7;A0A087WX29;A0A0A0N0M3;K7EN94;K7EJM5;A0A087WXQ5;A0A087WV68;Q13148-4;A0A087WXV3;A0A087WX67;A0A087WW61 Q13148 TARDBP;TDP43 TAR DNA-binding protein 43 1 9559600.0 3251700.0 1897400.0 4410500.0 True False 2703932.624734848 1887178.3295955856 5332715.158152078 1.0 0.6979383703322288 1.9722071139531494 21.366627773025662 -6.844186400692386 1.262822941081155 0.8392913665046748 2.017710868775147 0.9314125900466215 0.14238268262439258 0.16396638308676922 0.5061119474022776 0.08834365280259146 0.20381278079385853 1.4315733311749015e-07 6.844186400692386 1.1784195022704722 WCIYPTYDYTHCLCDSIEHITHSLCTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WCIYPTYDYTHCLCDSIEHITHSLCTK 27 0 P47897;P47897-2;A0A1B0GVU9;B4DDN1;A0A1B0GTT3 P47897 QARS Glutamine--tRNA ligase 0 41951000.0 12418000.0 12355000.0 17178000.0 False True 18839013.877405327 10150153.719944397 13782760.77061515 1.0 0.5387837063020606 0.7316073367908911 24.16722011369455 -10.21531471872124 5.473286849913185 1.0000185034422873 0.6351955215464442 0.8267623956687263 0.07871991750821232 1.7774970472903434e-05 2.548292075697878e-06 0.07622409444720779 0.025406744126994486 6.090953461952982e-11 10.21531471872124 -0.36482298189584306 WCK(ub)FDDDVVSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WCKFDDDVVSR 11 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 5257300.0 1736000.0 1945600.0 1575700.0 True False 2275912.8114479156 1655324.063889399 1412661.679181684 1.0 0.7273231450533012 0.6207011411315714 21.11801385943744 -13.999999999995087 0.12982283148320914 2.2957945838524907 0.4710478539506802 0.9996464183186031 0.0030032945478344385 11.937036597792755 0.11203050875903203 3.947587371587325 0.1330829349303038 1.0000000000113135e-14 13.999999999995087 -1.8247467299018105 WCK(ub)FDDDVVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WCKFDDDVVSR 11 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 19747300.0 5237800.0 8404600.0 6104900.0 True False 7946125.534472039 6904733.464560487 4898263.839127279 1.0 0.8689434158328151 0.6164342380292803 22.921820154913497 -6.960768399586799 0.42446687017156015 1.010638974882051 0.46514327322817156 0.9997976403770663 0.0022644527336005034 0.07942778530456611 0.0201256094084748 0.003276804071548584 0.02099443339160624 1.0945399065312709e-07 6.960768399586799 -0.5454957016538795 WCK(ub)FDDDVVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WCKFDDDVVSR 11 1 Q93009;A0A669KBL1;Q93009-3;H3BND8;F5H2X1 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 1 15912600.0 5237800.0 4757200.0 5917600.0 True False 6780435.352473609 4492457.638085112 4840657.519703492 1.0 0.6625618274564321 0.713915444667951 22.692946477005947 -10.294894930216072 5.611247661452381 1.0000344590356114 0.6882386360622338 0.980056116290848 0.0209650264357551 9.038738789440486e-06 1.1357927823040252e-06 0.02030153917363568 0.006766433186537354 5.0711338044923406e-11 10.294894930216072 -0.3117958229733776 WCPAPDCHHVVK(ub)VQYPDAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WCPAPDCHHVVKVQYPDAK 19 1 Q9Y4X5;H3BNB9 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 31390700.0 11852500.0 3981100.0 15557100.0 True False 15538742.279773286 3387135.3982062605 13947400.526240662 1.0 0.21798002291442084 0.8975887671678507 23.88936639960672 -10.757059129263318 9.652632296845935 1.001998090564 0.5577843950419705 0.36083142986959993 0.27744910802575545 0.011960477392302627 0.00030102493098842117 0.26932156039537347 0.0895463145669878 1.7496084629351427e-11 10.757059129263318 -0.4442136955220295 WCPAPDCHHVVK(ub)VQYPDAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WCPAPDCHHVVKVQYPDAK 19 1 Q9Y4X5;H3BNB9 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 39699500.0 23900000.0 9080700.0 6718800.0 True False 36258047.324044734 7460178.13716707 5390826.2350453455 1.0 0.2057523415559064 0.14867944174893247 25.111797895091357 -13.714231605189003 0.3763303856236973 9.999999999999996 0.14327033743686593 0.9997947455595965 0.005566829132100367 18.890219716441138 0.1992399487813423 136.30318784421013 0.015648102756836448 1.9309382910424572e-14 13.714231605189003 -9.856729662563131 WCPAPDCHHVVK(ub)VQYPDAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WCPAPDCHHVVKVQYPDAK 19 1 Q9Y4X5;H3BNB9 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 38511200.0 23900000.0 10401000.0 4210200.0 True False 30939021.139432408 9822175.20678619 3443986.800300057 1.0 0.3174688417749464 0.11131531229702113 24.882924217183806 -11.073394909436713 0.23319249172443296 2.0396474078706004 1.973549543974955e-21 0.9992471564065816 0.010420452077394528 3.1844561451981153 0.12874478813510265 1.8611757906160062 0.10290787423952244 8.445105718242809e-12 11.073394909436713 -2.0396474078706004 WCPAPDCHHVVK(ub)VQYPDAKPVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WCPAPDCHHVVKVQYPDAKPVR 22 2 Q9Y4X5;H3BNB9 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 11944300.0 1977300.0 3764200.0 6202800.0 True False 2592259.4482004414 3202596.032736678 5560993.757459002 1.0 1.235445794193145 2.145230394017647 21.305778687971188 -6.9456692781343765 0.6045228459866135 0.989845950610542 2.4377656088393174 0.9988161091126567 0.01699110741122419 0.08527276000055017 0.04352855799327002 0.01736182754470078 0.07657074823182886 1.1332630317932883e-07 6.9456692781343765 1.4479196582287752 up WCPAPDCHHVVK(ub)VQYPDAKPVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WCPAPDCHHVVKVQYPDAKPVR 22 2 Q9Y4X5;H3BNB9 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 93923600.0 46442000.0 25167600.0 22314000.0 True False 70455909.36499101 20676245.144643668 17903628.119426347 1.0 0.2934636048416051 0.25411109274990806 26.070217379320336 -13.60583930288093 0.4147152270005121 9.999999988971032 0.2525322155264866 0.9998511172080916 0.004181740621914593 20.652182759426196 0.213617158154221 166.098079967159 0.009682709306115766 2.4783389199651767e-14 13.60583930288093 -9.747467773444546 WCPAPDCHHVVK(ub)VQYPDAKPVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WCPAPDCHHVVKVQYPDAKPVR 22 2 Q9Y4X5;H3BNB9 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 11120400.0 1977300.0 5691200.0 3451900.0 True False 2708361.2445233227 5439743.965718342 2636632.314112078 1.0 2.0085001499405775 0.9735157447861542 21.36898874949408 -6.652115480032569 2.0011592074327194 1.6533334000579953 0.9778846562759601 0.20257392045366307 0.4302191322195959 0.5033904696238279 3.8664707598755865 0.1742171302252139 0.47652787587961853 2.2278426813396428e-07 6.652115480032569 -0.6754487437820352 WCPAPDCHHVVK(ub)VQYPDAKPVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WCPAPDCHHVVKVQYPDAKPVR 22 2 Q9Y4X5;H3BNB9 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 56760700.0 46442000.0 5902500.0 4416200.0 True False 60120084.50868283 5574020.6862854995 3612496.9140385557 1.0 0.09271478461545529 0.06008802122553274 25.841343701412786 -13.020424439412903 0.4859060319507123 9.999999994483263 0.06131255061955957 0.999917558900356 0.003955046302652183 16.36100407594645 0.24315195781326948 154.65706679802054 0.006828544521698833 9.54059720178886e-14 13.020424439412903 -9.938687443863703 WCTVTK(ub)CAGGHDDATLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WCTVTKCAGGHDDATLAR 18 1 P49916-3;P49916;P49916-4;P49916-2 P49916-3 LIG3 DNA ligase 3 1 17644400.0 6825500.0 5692200.0 5126700.0 True False 8948296.598236019 4842945.948021817 4596238.262778918 1.0 0.5412142852949811 0.5136439334928814 23.093181645760612 -13.999999999999998 0.4001015024404012 8.738684981204004 0.5120293927556937 0.9998379118984612 0.0028398081481121017 26.784706249724163 0.2084762491068111 179.95280045962355 0.007052541869111123 1.0000000000000041e-14 13.999999999999998 -8.226655588448311 WCTVTK(ub)CAGGHDDATLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WCTVTKCAGGHDDATLAR 18 1 P49916-3;P49916;P49916-4;P49916-2 P49916-3 LIG3 DNA ligase 3 1 52639000.0 15612000.0 13720000.0 23307000.0 True False 23684545.390083123 11271558.805150738 18700361.234179005 1.0 0.4759035320082696 0.7895596443243944 24.497442644774836 -10.322110479210359 5.955569837525005 1.000033710499976 0.632731588166336 0.6464048881504589 0.12804957164660158 5.732017530595431e-05 6.524673758842685e-06 0.12399481723432434 0.04132782153968979 4.7630980399736386e-11 10.322110479210359 -0.3673021223336399 WCTVTK(ub)CAGGHDDATLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WCTVTKCAGGHDDATLAR 18 1 P49916-3;P49916;P49916-4;P49916-2 P49916-3 LIG3 DNA ligase 3 1 19967500.0 6825500.0 5906500.0 7235500.0 True False 9349071.802201943 5645531.299816446 5526623.919800079 1.0 0.6038600857131914 0.5911414562564831 23.156391707283504 WCTVTK(ub)CAGGHDDATLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WCTVTKCAGGHDDATLAR 18 1 P49916-3;P49916;P49916-4;P49916-2 P49916-3 LIG3 DNA ligase 3 1 41598800.0 15612000.0 9228800.0 16758000.0 True False 20210041.75852799 8715209.167232795 13708215.951600496 1.0 0.43123162590969194 0.6782873640434744 24.268568966867285 -10.34949803966732 5.860981377129026 1.0000685511573508 0.5547594949765884 0.8124003850650396 0.10086008274240761 9.035919922941762e-05 1.0028924954793518e-05 0.09767230573251885 0.032552451729870105 4.472001703709942e-11 10.34949803966732 -0.44530905618076244 WDEEWDKNK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 WDEEWDKNK 9 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 6377320.0 3782900.0 1646000.0 948420.0 True False 4959418.5336557105 1400423.216057746 850286.5962870442 1.0 0.28237649364621364 0.1714488483915627 22.241739551269685 -13.999999999999998 0.2628374015550438 6.331982019694992 0.1319940048667846 0.9995681767645048 0.0076313713666777225 14.544371724911498 0.1622459333323187 41.26045407485751 0.04778177453451765 1.0000000000000041e-14 13.999999999999998 -6.199988014828207 WDEEWDKNK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 WDEEWDKNK 9 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 11300300.0 5907600.0 3300100.0 2092600.0 True False 5720066.471656754 4617847.13979415 1544485.2833456462 1.0 0.8073065518863878 0.2700117718908786 22.447600481672655 -6.953083208212886 0.5239059628536419 1.0088621685232302 0.04431809295816288 0.9994215418429436 0.007429081675315917 0.08227085435323965 0.031017970689833207 0.00836481840962722 0.04439892004517677 1.1140810619059268e-07 6.953083208212886 -0.9645440755650673 down WDEEWDKNK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WDEEWDKNK 9 1 Q14677;Q14677-3;Q14677-2 Q14677;Q14677-3 CLINT1 Clathrin interactor 1 1 10479800.0 5907600.0 3377300.0 1194900.0 True False 4912431.151054397 3359105.814558439 1444748.0654066282 1.0 0.683797026618367 0.29410042013444393 22.22800575710693 -7.195955479888205 0.3345585646955282 1.0528875062686591 1.2899212877239217e-17 0.9998697787248332 0.0032945096673591273 0.08871691685043417 0.018808011262833643 0.008976646444742345 0.04107482382884637 6.368608030197575e-08 7.195955479888205 -1.0528875062686591 down WDETK(ub)GEDNIDFMPTILSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WDETKGEDNIDFMPTILSR 19 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 32451800.0 6454400.0 7968400.0 18029000.0 True False 6249508.604959936 11150223.674657045 13306664.041593552 1.0 1.7841760655882042 2.129233653832029 22.57531132532959 -10.142217617203945 0.190471434155378 1.7410384349989846e-16 2.461404455137314 0.9994687831018859 0.010889864591680766 1.719683571370652 0.09062966352140875 1.0858187414175275 0.22298406499056977 7.207462356253319e-11 10.142217617203945 2.461404455137314 WDETK(ub)GEDNIDFMPTILSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WDETKGEDNIDFMPTILSR 19 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 56275100.0 7398100.0 12411000.0 36466000.0 True False 11223458.573557127 10196160.08241441 29258479.116384402 1.0 0.9084686342975354 2.6069040059824724 23.420013983477592 -6.894166494323485 0.9973920462591774 0.9176458110333411 2.7655002116540084 0.9834344081873506 0.1003881066789572 0.11582830968487925 0.20261346803177785 0.07623861709641645 0.19315156215192902 1.2759495576386429e-07 6.894166494323485 1.8478544006206672 up WDETK(ub)GEDNIDFMPTILSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WDETKGEDNIDFMPTILSR 19 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 28052200.0 6454400.0 8084800.0 13513000.0 True False 5367119.578401631 8041245.577692856 16338505.82294731 1.0 1.4982422992870228 3.0441851693964015 22.355716600763866 -6.950691225392863 0.5512072689382153 0.9787714607482548 3.6364321190502396 0.9992543880007363 0.023764458874871722 0.08320945740049489 0.034823446062808495 0.025753548037740406 0.12827842539423479 1.1202340641987066e-07 6.950691225392863 2.657660658301985 WDETK(ub)GEDNIDFMPTILSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WDETKGEDNIDFMPTILSR 19 1 P33992;B1AHB1 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 93104100.0 7398100.0 15580000.0 70126000.0 True False 9576986.288352925 14712959.304079296 57363787.553522885 1.0 1.5362827993157406 5.9897535431669136 23.19114030557004 -6.929407711268832 0.751637302450433 0.9307658143942812 6.890390674185053 0.9964205329679914 0.13380862875476504 0.09294669648483597 0.07919534153994963 0.12147904220877154 0.4042833112641055 1.1765009677039306e-07 6.929407711268832 5.959624859790772 up WDFTPCK(ub)NLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WDFTPCKNLR 10 1 P38606;P38606-2;C9JVW8;C9JA17 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 1 15302600.0 4270800.0 2329200.0 8702600.0 True False 3551359.428519718 2316652.1372899995 10522273.42372392 1.0 0.6523282658144319 2.9628860822205842 21.759939950381845 -6.868579828633011 1.1416414421405947 0.8049772328693828 3.0945669022158673 0.9632420186271624 0.19502358148814333 0.13822065626383492 0.3375928047115893 0.1326911303688144 0.31338678629910266 1.3533812997850398e-07 6.868579828633011 2.2895896693464843 up WDNLIYYALGGHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WDNLIYYALGGHK 13 0 Q15269;A0A0B4J2E5 Q15269 PWP2 Periodic tryptophan protein 2 homolog 0 11685800.0 3473000.0 2750600.0 5462200.0 False True 4553136.632579839 2340221.201754824 4897023.941122173 1.0 0.5139800077619981 1.0755275618310371 22.11842932237505 -6.6778132880665035 1.90977911564934 0.6918819237584773 1.0733476457778859 0.31405400422053276 0.20608713890440486 0.443421259909798 3.124940291221866 0.08665227657267538 0.22917153014003058 2.0998424541018513e-07 6.6778132880665035 0.38146572201940854 WDNLIYYALGGHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WDNLIYYALGGHK 13 0 Q15269;A0A0B4J2E5 Q15269 PWP2 Periodic tryptophan protein 2 homolog 0 14343900.0 3473000.0 4867300.0 6003600.0 False True 4757061.954295999 4652246.591991306 4585673.328023194 1.0 0.9779663659393721 0.963971748125326 22.18163938389794 WDVSTTK(ub)AR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WDVSTTKAR 9 1 P07814;V9GYZ6;V9GZ76 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 3300240.0 908050.0 1554100.0 838090.0 True False 1190462.3435687101 1322234.3378343524 751372.486326952 1.0 1.1106897626602976 0.6311602297931778 20.183090555656154 -6.845952253100989 1.25444712620798 1.0589227238867316 0.6134342501847674 0.9342098629487424 0.05258294632253017 0.1619643884655136 0.4925014704036851 0.03283154031245916 0.07580409612624141 1.4257643353673638e-07 6.845952253100989 -0.4454884737019642 WDVSTTK(ub)AR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WDVSTTKAR 9 1 P07814;V9GYZ6;V9GZ76 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 5571400.0 1263700.0 1889200.0 2418500.0 True False 1223584.5352144074 2643567.4120478495 1785022.2965552157 1.0 2.1605106439046486 1.458846728757019 20.222682347342673 -10.220202855479675 5.585057161372072 0.9999642646611857 1.80967868633087 0.639696697647461 0.28645309383933243 0.00012746829058557475 1.7797824269715805e-05 0.2773691980990442 0.0924523384924246 6.022782010315184e-11 10.220202855479675 0.8097144216696843 WDVSTTK(ub)AR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WDVSTTKAR 9 1 P07814;V9GYZ6;V9GZ76 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 3540950.0 908050.0 1201400.0 1431500.0 True False 1243780.6241285605 1148318.17550148 1093409.182667932 1.0 0.9232481622762333 0.8791013153416951 20.246300617179045 -13.99999594064175 0.06233515984765647 1.4765328728341676 0.69009955914051 0.9999479878141383 0.0003602006012136504 12.439704079234868 0.06473027561725127 0.9087938614353704 0.17639270352443417 1.000009347061478e-14 13.99999594064175 -0.7864333136936575 WDVSTTK(ub)AR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WDVSTTKAR 9 1 P07814;V9GYZ6;V9GZ76 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 1 5737500.0 1263700.0 2802900.0 1670900.0 True False 1050822.5414021662 2787800.2213679096 2020277.4646312913 1.0 2.6529695657727377 1.9225676886751324 20.00308762277695 -10.08899252009394 4.911417595233491 0.9999567989794013 2.287768627232296 0.8056243249506412 0.29818531770559153 0.0001410615138142279 2.616585044178569e-05 0.2887263057145414 0.09623889745898759 8.14718315891478e-11 10.08899252009394 1.2878118282528948 WDYLTQVEK(ub)ECK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WDYLTQVEKECK 12 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 8786100.0 2903300.0 4257100.0 1625700.0 True False 3806254.4155971976 3621957.2740458264 1457488.1588155534 1.0 0.9515804459112975 0.382919269096434 21.85994056600002 -6.923706689496225 0.7967530803866664 1.0109514766243781 0.28291520704402573 0.9951501363758121 0.019512019477608448 0.0960396887935522 0.09467044941639137 0.017150474285395727 0.053344780235924226 1.1920468117342188e-07 6.923706689496225 -0.7280362695803524 down WDYLTQVEK(ub)ECK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WDYLTQVEKECK 12 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 12727800.0 7412200.0 3288600.0 2027000.0 True False 7176903.768233151 4601755.129822445 1496067.891303463 1.0 0.6411894708956548 0.20845589402012743 22.77493014573641 -7.440871423088343 0.39097998763372444 1.0390103180498025 8.155422403884849e-12 0.99918862723952 0.009218070274992801 0.11602256869193903 0.04175026593952208 0.016976110063885965 0.06239574442150464 3.6235025969509085e-08 7.440871423088343 -1.039010318041647 down WDYLTQVEK(ub)ECK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WDYLTQVEKECK 12 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 32156200.0 11027000.0 9429200.0 11700000.0 True False 16728765.18168375 7746485.589324142 9387489.871707821 1.0 0.46306380089582067 0.561158565486121 23.995827622318927 -9.867876088522536 5.466452936893176 1.000000315950306 0.5121111831876161 0.9705734326799567 0.040047019959707955 1.5420063016281098e-07 3.192109933105439e-08 0.038775385181644535 0.01292512011232183 1.3555761257155832e-10 9.867876088522536 -0.48788913276268986 WDYLTQVEK(ub)ECK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WDYLTQVEKECK 12 1 Q9HB71;Q9HB71-3 Q9HB71 CACYBP Calcyclin-binding protein 1 43637000.0 11027000.0 13077000.0 19533000.0 True False 14274668.874666171 12349253.454393122 15978194.425504971 1.0 0.8651166316235775 1.1193390589859578 23.766953944411377 -6.762560289978653 1.6027292379257005 0.9219001744022248 1.1203897914954715 0.7013260254504429 0.05675542357570752 0.2786610683627192 1.41131850785546 0.02793188224989641 0.06695890448197875 1.7275861355051534e-07 6.762560289978653 0.19848961709324664 WEEFYQGK(ub)QANL ddPTM_RPMI8226_Bortezomib_1h_R1 1 WEEFYQGKQANL 12 1 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9;A0A0C4DGI9 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 8204700.0 2555200.0 2833800.0 2815700.0 True False 3349891.9445920005 2411008.0860658856 2524358.374101588 1.0 0.719727121335412 0.7535641196358176 21.67568312951683 -10.050871698694106 7.331558811238095 1.000000028970084 0.7366456206135278 0.987770186831605 0.013813896710569337 6.543833719490866e-09 8.56320374290133e-10 0.01337524937171 0.004458415992188685 8.894638486152984e-11 10.050871698694106 -0.2633544083565563 WEEFYQGK(ub)QANL ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WEEFYQGKQANL 12 1 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9;A0A0C4DGI9 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 8037200.0 2555200.0 3937000.0 1545000.0 True False 3499926.4916836033 3763050.322082009 1180102.8202738082 1.0 1.0751798162114636 0.337179315930756 21.738893191039722 -6.881796587215677 1.0697633165663722 1.0477965025022353 0.28304917939088114 0.9751045044947974 0.05232088938389291 0.12604898471352133 0.26278905872385383 0.037613579484061604 0.09138629176306902 1.3128146449229146e-07 6.881796587215677 -0.7647473231113542 down WEEFYQGK(ub)QANL ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WEEFYQGKQANL 12 1 J3KPG5;F8VU39;Q9UIF9-2;Q9UIF9-3;Q9UIF9;A0A0C4DGI9 J3KPG5 BAZ2A Bromodomain adjacent to zinc finger domain protein 2A 1 10349700.0 3192000.0 5016600.0 2141100.0 True False 2654289.429576416 4989574.580082865 2588794.1106721316 1.0 1.8798155636249227 0.9753247260172616 21.339894263260614 -6.652440664355221 1.9994473785797182 1.5697894957357081 0.9790955048509601 0.20418714336472665 0.3752867266391863 0.5025563721143312 3.8536386942294154 0.1520632575336866 0.41583452353571404 2.226175176026183e-07 6.652440664355221 -0.590693990884748 WENHNK(ub)SLQLEAQTYQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WENHNKSLQLEAQTYQR 17 1 O95376 O95376 ARIH2 E3 ubiquitin-protein ligase ARIH2 1 26360000.0 10169000.0 7878100.0 8312900.0 True False 9846190.66122917 11023866.413748777 6135502.108345609 1.0 1.11960724640006 0.6231346029591986 23.231134245454605 -6.843085416940397 1.267993076641696 1.063624899849033 0.6057824600453093 0.9296300308667744 0.056121223549524354 0.16522515444161456 0.5146894566507626 0.0346866713734917 0.07998973485812562 1.435207129379481e-07 6.843085416940397 -0.45784243980372363 WENHNK(ub)SLQLEAQTYQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WENHNKSLQLEAQTYQR 17 1 O95376 O95376 ARIH2 E3 ubiquitin-protein ligase ARIH2 1 26167300.0 7901400.0 14197000.0 4068900.0 True False 11987001.469715765 11663434.428332727 3264680.13153778 1.0 0.9730068406014211 0.272351691937783 23.514967480111906 -6.915034301545498 0.8607551676236415 1.0183950017570325 0.17133467610391365 0.9926864598819478 0.028805843467708616 0.10118252068885496 0.12140890313749589 0.024187212208919232 0.06934243795731579 1.2160899473604894e-07 6.915034301545498 -0.8470603256531188 down WENHNK(ub)SLQLEAQTYQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WENHNKSLQLEAQTYQR 17 1 O95376 O95376 ARIH2 E3 ubiquitin-protein ligase ARIH2 1 28443600.0 9772400.0 13281600.0 5389600.0 True False 13385520.369180037 12694774.995622136 4116687.48229625 1.0 0.948396076169864 0.3075478105262805 23.674169889812767 -6.922905914737591 0.8028881582504409 1.0127146227730506 0.1969700024994164 0.9949505797992798 0.022381345171017888 0.09649221972597458 0.09697714815778267 0.01958666118723402 0.06040461948831611 1.1942467972590334e-07 6.922905914737591 -0.8157446202736341 down WEQELNAK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 WEQELNAKR 9 1 O43463;O43463-2 O43463 SUV39H1 Histone-lysine N-methyltransferase SUV39H1 1 71038000.0 18832000.0 27067000.0 25139000.0 True False 18234188.46811564 37874994.25254036 18554341.746165607 1.0 2.0771417559256173 1.0175578572421684 24.120142656642436 -6.642332772342153 2.035734346950343 1.7031243194595487 1.0219539253514356 0.1637315519838125 0.4606057442160831 0.5275048470535048 4.180816087593785 0.18405889839276815 0.5101481471881434 2.2785954596105403e-07 6.642332772342153 -0.6811703941081131 WEQELNAK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 WEQELNAKR 9 1 O43463;O43463-2 O43463 SUV39H1 Histone-lysine N-methyltransferase SUV39H1 1 57426000.0 22269000.0 15699000.0 19458000.0 True False 33783701.08197293 12897390.793153157 15612117.771255625 1.0 0.381763702024798 0.4621198172862799 25.009824051560976 -10.635009362753488 6.598349162766526 1.0022575424778053 0.42194175965637853 0.9857141222761323 0.03280524668381712 0.0010924393174503808 6.0428725875064325e-05 0.031850034571095094 0.010587847839554148 2.3173446908696006e-11 10.635009362753488 -0.5803157828214267 WEQELNAK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WEQELNAKR 9 1 O43463;O43463-2 O43463 SUV39H1 Histone-lysine N-methyltransferase SUV39H1 1 33207900.0 10793000.0 13572000.0 8842900.0 True False 14783463.769857997 12972344.16339777 6754389.145242232 1.0 0.8774901718125817 0.4568881319284426 23.817480997168722 -6.948386114331641 0.5762927985805656 1.0051006042827288 0.3086062379722215 0.9990684440029379 0.0070989871030901095 0.08414041651880645 0.038695371263208815 0.007468058984709091 0.035100434232117506 1.1261957541135913e-07 6.948386114331641 -0.6964943663105074 down WEQELNAK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WEQELNAKR 9 1 O43463;O43463-2 O43463 SUV39H1 Histone-lysine N-methyltransferase SUV39H1 1 65579000.0 18832000.0 32960000.0 13787000.0 True False 15659642.39905484 32782437.937952224 16669797.956114471 1.0 2.0934346457318114 1.0645069364496216 23.900547932076712 -6.631882023514469 2.0738883976678846 1.7194032959670735 1.0687017073975784 0.12416786235775656 0.4688076431165139 0.5541608999725328 4.544652853762767 0.18474172191521715 0.5192013260261307 2.334092034362163e-07 6.631882023514469 -0.6507015885694951 WEQELNAK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WEQELNAKR 9 1 O43463;O43463-2 O43463 SUV39H1 Histone-lysine N-methyltransferase SUV39H1 1 48627800.0 22269000.0 19416000.0 6942800.0 True False 28827659.48761594 18335482.531964317 5679281.639143807 1.0 0.6360378489915579 0.19700807280534055 24.780950373653425 -7.46650958232079 0.4002766662181238 1.0367562086210897 3.9331180812365385e-18 0.9990205380236009 0.010274505695016164 0.11728825847796356 0.04539206454960004 0.017969513132580998 0.06429686223906582 3.4157841397954964e-08 7.46650958232079 -1.0367562086210897 down WETFCTSSLGETNK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 WETFCTSSLGETNKR 15 1 H7BXH2;E9PKF6;Q5H9R7-3;Q5H9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7;Q5H9R7-5;E9PQP7;H0YEN2;H0YDW1 H7BXH2 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 12116300.0 1348300.0 2380200.0 8387800.0 True False 1767634.3569557723 2025083.437946931 7519910.9174590055 1.0 1.1456461173534433 4.254223102118149 20.75338844701623 -6.916679199136452 0.8489977473134012 0.9228645490874255 4.719113209873191 0.9932075267253437 0.1236992476901119 0.10016517065769794 0.11603232388683199 0.10474621437153148 0.30445729801358956 1.2114926979847503e-07 6.916679199136452 3.7962486607857655 up WETFCTSSLGETNK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 WETFCTSSLGETNKR 15 1 H7BXH2;E9PKF6;Q5H9R7-3;Q5H9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7;Q5H9R7-5;E9PQP7;H0YEN2;H0YDW1 H7BXH2 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 7704300.0 2557800.0 1546900.0 3599600.0 True False 2476604.0390689312 2164585.236976932 2656756.7743147206 1.0 0.8740134485893427 1.0727418401988544 21.23993179740172 -6.735367716332117 1.70341021340556 0.924641219794614 1.0727505373713229 0.5841071906586872 0.05294314913190412 0.32624811361044964 1.8568040247674964 0.024605456453644033 0.06069505246729084 1.8392140828668097e-07 6.735367716332117 0.14810931757670887 WETFCTSSLGETNK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 WETFCTSSLGETNKR 15 1 H7BXH2;E9PKF6;Q5H9R7-3;Q5H9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7;Q5H9R7-5;E9PQP7;H0YEN2;H0YDW1 H7BXH2 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 69441100.0 8481100.0 21629000.0 39331000.0 True False 12866448.751462596 17769135.96185167 31557210.61061031 1.0 1.3810443196170787 2.4526744885237304 23.617110576695143 -6.952893049515271 0.5261247313376682 0.982614589602902 2.8994306462312602 0.9994092010348847 0.014948022026392224 0.0823444189649848 0.031312358398357235 0.016773733418494943 0.0885757516749229 1.114568976442745e-07 6.952893049515271 1.9168160566283583 up WETFCTSSLGETNK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WETFCTSSLGETNKR 15 1 H7BXH2;E9PKF6;Q5H9R7-3;Q5H9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7;Q5H9R7-5;E9PQP7;H0YEN2;H0YDW1 H7BXH2 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 10444500.0 1348300.0 1815100.0 7281100.0 True False 1846802.9464374597 1734902.8802669665 5561454.138961566 1.0 0.9394087677917388 3.011395530687117 20.816598508539123 -6.900163017583047 0.9602287209617455 0.9142392961412712 3.229613033594369 0.9866474721270081 0.11125228056336246 0.11128565276557352 0.17674041053738518 0.08686850026145902 0.2262044070199712 1.258452947892261e-07 6.900163017583047 2.315373737453098 up WETFCTSSLGETNK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WETFCTSSLGETNKR 15 1 H7BXH2;E9PKF6;Q5H9R7-3;Q5H9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7;Q5H9R7-5;E9PQP7;H0YEN2;H0YDW1 H7BXH2 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 13766100.0 2557800.0 2236600.0 8971700.0 True False 2126924.0297526773 2224550.99186966 10847640.989546103 1.0 1.0459005402879082 5.100154419153132 21.020337072835996 -6.909373256075346 0.899991338371892 0.8719705406513818 5.617136716505183 0.9906829224637362 0.18553108955520947 0.1048339428549202 0.14102575042412663 0.15142764651711346 0.416216265630566 1.2320454917945148e-07 6.909373256075346 4.745166175853801 up WETFCTSSLGETNK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WETFCTSSLGETNKR 15 1 H7BXH2;E9PKF6;Q5H9R7-3;Q5H9R7-4;Q5H9R7-6;Q5H9R7-2;Q5H9R7;Q5H9R7-5;E9PQP7;H0YEN2;H0YDW1 H7BXH2 PPP6R3 Serine/threonine-protein phosphatase 6 regulatory subunit 3 1 57548100.0 8481100.0 21035000.0 28032000.0 True False 10978951.137474494 19864383.75874894 22930463.632609174 1.0 1.8093152533438068 2.0885841776215344 23.388236898787593 -10.548119890825328 0.22597221970312154 1.698175931220021e-15 2.268985155035249 0.9992555405795074 0.012595727883060154 2.2576461261964544 0.11447989773275523 1.4092660616985577 0.14543154296491428 2.8306104729238195e-11 10.548119890825328 2.268985155035247 WETGEVQAQSAAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WETGEVQAQSAAK 13 0 P33241;P33241-3;E7EMG9;P33241-2;E9PBD8 P33241;P33241-2 LSP1 Lymphocyte-specific protein 1 0 14470400.0 1891600.0 6439300.0 6139500.0 False True 2479905.9182804553 5478581.540194805 5504243.434242528 1.0 2.209189267951586 2.21953719843498 21.2418539585634 -10.894682274492153 0.8108753641965784 2.9857617330380197e-05 2.217279545687482 0.9999902482833442 0.0017876909862203517 2.85540885671969 0.4349617358759425 5.437448588945336 0.0014833698678844627 1.2744351040464695e-11 10.894682274492153 2.2172496880701513 WETGEVQAQSAAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WETGEVQAQSAAK 13 0 P33241;P33241-3;E7EMG9;P33241-2;E9PBD8 P33241;P33241-2 LSP1 Lymphocyte-specific protein 1 0 11811900.0 2876300.0 1205900.0 7729700.0 False True 2784993.430907019 1687422.158685425 5705059.683970586 1.0 0.6058980750040276 2.04850023007507 21.40924249394189 -6.833896029468044 1.310322182726586 0.7899129218094597 2.09052647428922 0.9134575468374244 0.179098272826019 0.17605369428027487 0.5897634506738032 0.10726877977917999 0.2468820280626641 1.46589873657088e-07 6.833896029468044 1.3006135524797604 up WETGEVQAQSAAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WETGEVQAQSAAK 13 0 P33241;P33241-3;E7EMG9;P33241-2;E9PBD8 P33241;P33241-2 LSP1 Lymphocyte-specific protein 1 0 12624400.0 1891600.0 5053400.0 5679400.0 False True 2590975.6385678984 4830124.0786409 4338042.690914608 1.0 1.8642105339557105 1.6742892624464658 21.30506402008629 -10.098039042982913 4.411871121066488 0.9999235417035888 1.7692498981626625 0.9562820686159236 0.07753503462864451 11369092.661833439 8673993.414889226 7864.106811341601 0.02654230472320898 7.979229509374062e-11 10.098039042982913 0.7693263564590738 WETPYMHALAAAASSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WETPYMHALAAAASSK 16 0 Q14353;Q14353-2 Q14353 GAMT Guanidinoacetate N-methyltransferase 0 4550600.0 0.0 1468700.0 3081900.0 False True 0.0 1249575.6849477615 2763014.551672295 0.0 WETPYMHALAAAASSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WETPYMHALAAAASSK 16 0 Q14353;Q14353-2 Q14353 GAMT Guanidinoacetate N-methyltransferase 0 3361800.0 0.0 1104600.0 2257200.0 False True 0.0 1055795.1195762735 1724095.8484932273 0.0 WEVLIGSTHILTPQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WEVLIGSTHILTPQK 15 0 A0A0D9SG72;P61764 A0A0D9SG72 STXBP1 Syntaxin-binding protein 1 0 8851700.0 1770600.0 2338000.0 4743100.0 False True 2425238.668665849 2234699.429267904 3622877.4672108083 1.0 0.9214348501614634 1.4938230674030089 21.20969529978165 -6.872215334407552 1.1222476429937736 0.9549069282219151 1.5287963456290228 0.9668476853440154 0.0461288428690771 0.13475166860241064 0.31583196196339614 0.03185386014608514 0.0757228211015925 1.3420993486585966e-07 6.872215334407552 0.5738894174071076 WEWLVNQHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WEWLVNQHR 9 0 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 0 24986800.0 10285100.0 5861600.0 8840100.0 False True 13483865.701050097 4987072.128337842 7925411.252226963 1.0 0.36985477598975636 0.5877699635950651 23.68473082751296 -10.10553024658922 5.158714511530584 1.0000126671817715 0.47881236979159536 0.8840844225031578 0.0889635028089041 1.2961218094549619e-05 2.2475284907999268e-06 0.08614063335201512 0.028712847066176408 7.842774957027405e-11 10.10553024658922 -0.5212002973901761 WEWLVNQHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WEWLVNQHR 9 0 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 0 23693100.0 5831800.0 1932700.0 15928600.0 False True 5646672.701165921 2704437.188897356 11756421.812242886 1.0 0.47894350036242506 2.0820087216699186 22.428969579943992 -6.819192777520781 1.37550642461152 0.7189311979484879 2.116364679391636 0.8824944641476276 0.22887147295187973 0.1945265303978367 0.7234343142525971 0.1307667212139194 0.3014419854821715 1.5163771184946627e-07 6.819192777520781 1.3974334814431484 up WEWLVNQHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WEWLVNQHR 9 0 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 0 24456900.0 10285100.0 6555800.0 7616000.0 False True 14087779.414376587 6266143.078868489 5817257.656443567 1.0 0.44479281613920546 0.4129293542534498 23.747940889035853 -13.90660175142453 0.40749489951306217 9.9999999896114 0.41136123891598914 0.99984667769275 0.0033376732862639255 25.747760651093046 0.2110797414760605 204.86857000586383 0.007991400254220142 1.2399330855337354e-14 13.90660175142453 -9.588638750695411 WEWLVNQHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WEWLVNQHR 9 0 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 0 14637100.0 5831800.0 4522500.0 4282800.0 False True 4849400.092545024 4498136.394854036 5178313.678570177 1.0 0.9275655357389494 1.067825623736592 22.209374855378268 -6.7663853482082805 1.5887163351652651 0.9582609933777002 1.0685010997843765 0.7163791611837163 0.03050041048221511 0.27231914880874036 1.3559760513775172 0.015138913460452087 0.03615148621515942 1.7124371927591795e-07 6.7663853482082805 0.11024010640667625 WEYVPLGPFLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WEYVPLGPFLGK 12 0 P16930;P16930-2 P16930 FAH Fumarylacetoacetase 0 3937100.0 1057500.0 1440900.0 1438700.0 False True 1386392.7408445668 1225923.3365842078 1289837.1249848912 1.0 0.8842540071562955 0.9303547883546652 20.40290457500027 -10.71734545549484 9.025337938432182 1.0002606191630095 0.9073043978792713 0.8435211671467117 0.018820565113283023 9.897176005818335e-05 3.0995919814126236e-06 0.018273640198286194 0.0060743112708297855 1.9171431603512573e-11 10.71734545549484 -0.09295622128373815 WEYVPLGPFLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WEYVPLGPFLGK 12 0 P16930;P16930-2 P16930 FAH Fumarylacetoacetase 0 5442000.0 2552300.0 1008300.0 1881400.0 False True 2471278.6335583846 1410919.4482150376 1388604.8992098325 1.0 0.5709268995635106 0.5618973434858641 21.23682625121325 WEYVPLGPFLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WEYVPLGPFLGK 12 0 P16930;P16930-2 P16930 FAH Fumarylacetoacetase 0 6587000.0 1057500.0 2712300.0 2817200.0 False True 1448486.3278629489 2592461.6176233212 2151835.382055254 1.0 1.7897729289914373 1.4855752109376168 20.466114636523162 -10.099783961307102 4.648468877989213 0.9999663293766847 1.6376740699816 0.8542063955937037 0.12418819848981544 86443869.71568017 2.9290863526355353 38568.07706698369 0.04251292353496522 7.947234695941386e-11 10.099783961307102 0.6377077406049152 WFEENASQSTVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WFEENASQSTVK 12 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 16781300.0 1032700.0 7950500.0 7798100.0 False True 1353879.7006810252 6764316.390806277 6991227.416657166 1.0 4.996246259843994 5.163846841887397 20.368668122903756 -10.114680180146594 0.695887433442497 1.3677095510760011e-22 5.135642533733071 0.9998160269414381 0.02610421294982896 1.395923061939272 0.34750361270207836 2.9508102688358013 0.026156957358348377 7.679267920209102e-11 10.114680180146594 5.135642533733071 WFEENASQSTVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WFEENASQSTVK 12 0 Q12905;B4DY09 Q12905 ILF2 Interleukin enhancer-binding factor 2 0 14757100.0 1032700.0 5068500.0 8655900.0 False True 1414517.0976681486 4844556.910711875 6611554.693856342 1.0 3.4248839541764435 4.6740719534289 20.431878184426647 -8.790869733856155 0.28486246643811175 4.645832739983466e-20 5.356813813737443 0.9988363167989005 0.05203284760610448 0.3256290074447698 0.09030576884327722 0.7822567801728777 0.44153155348108064 1.6185654517356939e-09 8.790869733856155 5.356813813737443 WFGFLEAQQAFQSVGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WFGFLEAQQAFQSVGTK 17 0 P07814;V9GYZ6;V9GZ76 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 10586600.0 4620300.0 1820600.0 4145700.0 False True 4473631.105524354 2547575.074303577 3059816.801665895 1.0 0.5694647176334349 0.6839671688368356 22.093014866362097 -10.179019899583517 7.826692073381405 1.0000001401138279 0.6267159432351405 0.9340830014511939 0.04674542995771025 1.1429529898019702e-07 1.1891758291265132e-08 0.04526108479515363 0.015087022644793094 6.621861613159655e-11 10.179019899583517 -0.3732841968786874 WFGFLEAQQAFQSVGTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WFGFLEAQQAFQSVGTK 17 0 P07814;V9GYZ6;V9GZ76 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 9716400.0 4620300.0 2689100.0 2407000.0 False True 3841984.1639949568 2674613.284555442 2910292.571289441 1.0 0.6961541668027951 0.7574972844925192 21.873420141796373 -10.760839734492658 6.971522244824924 1.0058766345199643 0.7268257256477033 0.9635588863496034 0.025043222928553422 0.0023160636640840128 7.9453172142907e-05 0.02455149632711472 0.008082665444803933 1.7344439327878893e-11 10.760839734492658 -0.279050908872261 WFLTCINQPQFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WFLTCINQPQFR 12 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 208027000.0 62890000.0 100980000.0 44157000.0 False True 82449399.02762637 85914177.61695716 39588057.22385337 1.0 1.0420230908920252 0.4801497365746545 26.297005642131126 -6.8888815369342815 1.0289977291955 1.03100468820682 0.4328730429305676 0.9801719204307793 0.035983326508112645 0.12005445316072189 0.22719666867958593 0.026683513608442896 0.06625883104112776 1.2915715291998505e-07 6.8888815369342815 -0.5981316452762524 down WFLTCINQPQFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WFLTCINQPQFR 12 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 105664000.0 70486000.0 18035000.0 17143000.0 False True 68248460.51208568 25236469.551282536 12652734.021023791 1.0 0.36977346246240345 0.1853922260822748 26.024293167582794 -13.999999999999945 0.17230973749858913 4.197924938647727 0.026682574366920876 0.9995094619497931 0.007724599520418213 12.114841590590176 0.1314923896220031 12.952883067149285 0.14722050606684137 1.0000000000001268e-14 13.999999999999945 -4.171242364280806 WFLTCINQPQFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WFLTCINQPQFR 12 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 323382000.0 96746000.0 127160000.0 99476000.0 False True 146770755.08000147 104467304.49438526 79814524.99812043 1.0 0.7117719360198321 0.5438040088750331 27.12898929060275 -11.095022857280302 0.08465545931221465 2.0183803011965447 2.936104891646279e-12 0.9999371702556037 0.0014932342039764908 3.551852528407995 0.05289623701718965 1.0506656857013232 0.35212082424498087 8.03483833049424e-12 11.095022857280302 -2.0183803011936083 WFLTCINQPQFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WFLTCINQPQFR 12 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 371460000.0 62890000.0 128090000.0 180480000.0 False True 86142132.53834604 122430560.26301344 137854341.10227633 1.0 1.4212622401530826 1.6003126117281887 26.360215703654017 -11.550917281604061 0.15071750089613972 7.692751407166208e-17 1.8272177640923748 0.9996139885192002 0.004943976738556679 4.3567086697996995 0.09617611627987714 1.596197004225266 0.1705794904039121 2.812436453318766e-12 11.550917281604061 1.8272177640923748 WFLTCINQPQFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WFLTCINQPQFR 12 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 136033000.0 70486000.0 13980000.0 51567000.0 False True 58612232.05924906 13904686.965187253 62349421.281131126 1.0 0.23723182818104405 1.0637612506908845 25.80469844301707 -12.060804659163907 14.937621210672482 0.9442000786557454 0.6854468855491229 0.0 0.3842577946877291 0.0 0.0 0.0 0.11183256516879075 8.693513659524322e-13 12.060804659163907 -0.2587531931066225 WFLTCINQPQFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WFLTCINQPQFR 12 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 403896000.0 96746000.0 150330000.0 156820000.0 False True 125239604.14876698 141964003.34930933 128280369.1090817 1.0 1.1335392211929711 1.0242795797781565 26.9001156126952 -10.372693266728309 5.588849225778154 0.9999753867770715 1.0789094004854993 0.41019208255308737 0.04460506182429457 1.3685156951101091e-05 1.5360349628986733e-06 0.043202133895869105 0.014396221800170167 4.2394228206231197e-11 10.372693266728309 0.07893401370842779 WFNGQPIHAELSPVTDFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WFNGQPIHAELSPVTDFR 18 0 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 0 33977500.0 6867500.0 15680000.0 11430000.0 False True 9003359.004964609 13340605.120161291 10247333.244301993 1.0 1.48173644001145 1.138167792559581 23.10203191695618 -10.286821724098417 9.372006593045148 0.9999999358227954 1.3099521162855154 0.5204245873893223 0.14026131297920721 1.8807042721853945e-07 1.4467252188632336e-08 0.13580746065279636 0.04526914410713797 5.1662839934911546e-11 10.286821724098417 0.30995218046272 WFNGQPIHAELSPVTDFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WFNGQPIHAELSPVTDFR 18 0 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 0 34463100.0 13965000.0 6889100.0 13609000.0 False True 13521688.719054507 9639953.556181898 10044394.638751263 1.0 0.7129252681728621 0.7428358134436931 23.6887720047713 -10.317641972499434 5.481795235627347 1.0000494550001047 0.7278805410106747 0.9910200634157005 0.012210928973680693 7.381841016607266e-06 9.188646530127185e-07 0.01182532527010915 0.003941060379729072 4.812359104544823e-11 10.317641972499434 -0.27216891398943 WFNGQPIHAELSPVTDFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WFNGQPIHAELSPVTDFR 18 0 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 0 48141900.0 5794900.0 31884000.0 10463000.0 False True 8791286.963937536 26194051.089170966 8394983.463904185 1.0 2.979546816822243 0.9549208777214286 23.067642947500836 -6.65136443570865 2.0042909243219245 2.283171628766754 0.9635320714954108 0.19942879455439833 0.8446155772535289 0.5051437745434769 3.8913964717377003 0.3416314931611108 0.9352301846227167 2.2316987197668316e-07 6.65136443570865 -1.3196395572713433 WFNGQPIHAELSPVTDFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WFNGQPIHAELSPVTDFR 18 0 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 0 36079500.0 6867500.0 17095000.0 12117000.0 False True 9406600.337209279 16339686.374394687 9255214.157448359 1.0 1.7370448183878402 0.9839063876072115 23.16524197847907 -10.240015362522707 3.984930565710895 0.9996809787278635 1.3604756030287435 0.2339809244175446 0.3074674772099185 41720080.24137147 35736168.90449434 108115.52101180231 0.10525429380568006 5.754195823634716e-11 10.240015362522707 0.36079462430087994 WFNGQPIHAELSPVTDFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WFNGQPIHAELSPVTDFR 18 0 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 0 26290900.0 13965000.0 8482700.0 3843200.0 False True 11612516.254396798 8437002.011415873 4646795.351050926 1.0 0.726543827934054 0.40015404493333045 23.469177280205578 -6.968776212730307 0.28590788132332895 1.0669777304846297 0.049693198880952145 0.9999712011561306 0.001315862119673529 0.0767018151947451 0.010444577001688951 0.005830921884685738 0.02974150216813836 1.074542970128778e-07 6.968776212730307 -1.0172845316036776 down WFNGQPIHAELSPVTDFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WFNGQPIHAELSPVTDFR 18 0 P0DN76;Q01081;Q01081-2;Q01081-4 P0DN76 U2AF1 Splicing factor U2AF 35 kDa subunit 0 28559900.0 5794900.0 11709000.0 11056000.0 False True 7501612.284556365 11057383.856961772 9043921.444139805 1.0 1.4740009797261457 1.2055970238236127 22.838769269593286 -10.103452736183971 4.563410741423242 0.9999724640946508 1.3397990017851236 0.6812243921561367 0.10957545618588237 76300061.12775066 0.40816769007067505 22076.923055485266 0.03751059318348582 7.880381881598984e-11 10.103452736183971 0.3398265376904728 WFQQK(ub)YDGIILPGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WFQQKYDGIILPGK 14 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 10563600.0 2218500.0 4365700.0 3979400.0 True False 2908474.9839845574 3714354.5773653146 3567649.8611002103 1.0 1.2770797747336018 1.2266393490559082 21.47183146481318 -10.127014360902116 4.91856455643199 0.9999871967001259 1.2518595618957817 0.9707968137129966 0.020592217556738134 2.8912693134496887e-06 5.131898004306762e-07 0.019939341957693122 0.006646109637720606 7.464240758484222e-11 10.127014360902116 0.2518723651956558 WFQQK(ub)YDGIILPGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WFQQKYDGIILPGK 14 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 17903400.0 4697900.0 4646900.0 8558600.0 True False 4548767.736000442 6502431.403263361 6316845.907503612 1.0 1.4294929485629664 1.388693878016681 22.117044340582652 -10.344688254290448 5.225453577155115 0.9998459997657959 1.4090934132898505 0.9925956109349814 0.016656150803129065 2.9893981471132373e-05 3.748908860088429e-06 0.01613326348449186 0.005375749556023053 4.521804125125351e-11 10.344688254290448 0.4092474135240546 WFQQK(ub)YDGIILPGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WFQQKYDGIILPGK 14 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 109683900.0 7375900.0 13613000.0 88695000.0 True False 11189779.550519725 11183653.791145535 71164394.37360054 1.0 0.9994525576356055 6.359767326273663 23.415678278318087 -6.906868173989916 0.9167794701132823 0.8171515003071557 7.008066540619896 0.9896855282682688 0.256616959652196 0.10652616092383711 0.1502634086500615 0.20689522655861464 0.5594728216758512 1.239172668671782e-07 6.906868173989916 6.19091504031274 up WFQQK(ub)YDGIILPGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WFQQKYDGIILPGK 14 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 9325200.0 2218500.0 3497200.0 3609500.0 True False 3038739.402708227 3342682.140306116 2757010.43998596 1.0 1.1000226400878619 0.9072875540195449 21.535041526336073 -6.7656670247772395 1.5910770487134864 1.05768725728243 0.9063774804313465 0.713701159163157 0.042111339150500596 0.2734935777117256 1.3656854444835842 0.020870870673127172 0.049880669804160366 1.715271908952714e-07 6.7656670247772395 -0.1513097768510836 WFQQK(ub)YDGIILPGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WFQQKYDGIILPGK 14 1 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 171001500.0 7375900.0 8675600.0 154950000.0 True False 9548247.9507255 8192795.233534683 126750689.92126133 1.0 0.8580417345479778 13.274758947962855 23.186804600410536 -6.904313551697083 0.9335823787666492 0.5430605448607212 14.698625752342 0.9885931736574224 0.6216053574924818 0.10829984053061965 0.16004896149828982 0.495021317227662 1.3182181201653385 1.246483253986258e-07 6.904313551697083 14.15556520748128 up WFSESGK(ub)LVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WFSESGKLVTK 11 1 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 13294900.0 2009600.0 6598200.0 4687100.0 True False 2634605.0609940826 5613774.279582154 4202123.8538379595 1.0 2.130783988346238 1.5949729680745488 21.329155280997224 -10.245396333623894 5.0759365051919625 0.9998724654104193 1.8628784782107957 0.7756800518454143 0.21874393303902606 0.0003157522412414737 4.694140543649503e-05 0.21182872465113128 0.07059930081180249 5.6833403707527954e-11 10.245396333623894 0.8630060128003764 WFSESGK(ub)LVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WFSESGKLVTK 11 1 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 15495270.0 3747670.0 6502500.0 5245100.0 True False 3628702.267220847 9098982.160089536 3871250.9603728587 1.0 2.5075030934015623 1.0668417178623406 21.791022258760556 -6.635554548584813 2.0605314013166063 1.9891192799133128 1.072769587827835 0.13779854133840586 0.6457351643114858 0.5446532450508038 4.413986607804317 0.25569388910735913 0.7150778196717167 2.3144374680283887e-07 6.635554548584813 -0.9163496920854779 WFSESGK(ub)LVTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WFSESGKLVTK 11 1 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 61486500.0 9713200.0 18670900.0 33102400.0 True False 14735634.53003813 15338932.018592453 26559696.130702652 1.0 1.0409413987110308 1.8024127889818076 23.812805849792507 -6.918010533967065 0.8393322876011173 0.9819650204218185 1.9197656027127368 0.9936107945064002 0.02949427767992638 0.09935600431462993 0.11177751724368112 0.02514841064062779 0.07395842181060386 1.2077845395080798e-07 6.918010533967065 0.9378005822909182 WFSESGK(ub)LVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WFSESGKLVTK 11 1 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 13874900.0 2009600.0 4446600.0 7418700.0 True False 2752603.427397998 4250134.509060164 5666555.8529225215 1.0 1.544041712204712 2.058616870312861 21.392365342520115 -6.971799669514428 0.2108209567315256 0.7333956768778025 2.8836410794068956 0.999993223616998 0.0011251554129630224 0.07572297492029284 0.006900419362789688 0.015309185210112998 0.05322164606121018 1.0670882320361509e-07 6.971799669514428 2.150245402529093 WFSESGK(ub)LVTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WFSESGKLVTK 11 1 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 13106170.0 3747670.0 4839900.0 4518600.0 True False 3116353.654931282 4813826.498055071 5463418.368354157 1.0 1.544698397897725 1.7531445314972216 21.571427534194832 -11.131967622499893 0.18200854326048932 1.8798795286913888e-16 1.9480964411902681 0.9994652640032441 0.0073424534941061775 3.3791446756898575 0.10502881207852605 1.5418250885820632 0.14910583945755773 7.379592443783867e-12 11.131967622499893 1.948096441190268 WFSESGK(ub)LVTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WFSESGKLVTK 11 1 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 1 54488900.0 9713200.0 13753500.0 31022200.0 True False 12573928.875796437 12988105.63470183 25376477.914652124 1.0 1.0329393273173861 2.01818207859433 23.583932171884957 -6.914007830763661 0.8680095814758256 0.9732236673751148 2.157051926027026 0.9923477950686296 0.04132435843223149 0.10182704821296872 0.12483764291894686 0.034518008204620046 0.09814930504675473 1.2189676195219627e-07 6.914007830763661 1.183828258651911 up WFTHASPTLFNAGTNRPQLSSCFLLSMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 WFTHASPTLFNAGTNRPQLSSCFLLSMK 28 1 P23921;H0YCY7 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit;Ribonucleoside-diphosphate reductase 0 257284000.0 109926000.0 85706000.0 61652000.0 False True 166765778.66706875 70411094.67596564 49466455.17696845 1.0 0.4222154883259015 0.29662233806207505 27.313248028621448 -13.999999999999998 0.2144759059047945 4.404547135010125 0.2257800078825356 0.9994929921646024 0.006896787620132309 12.855198852162347 0.14675494273157347 18.48363845480987 0.07212910580050079 1.0000000000000041e-14 13.999999999999998 -4.178767127127589 WFTHASPTLFNAGTNRPQLSSCFLLSMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 WFTHASPTLFNAGTNRPQLSSCFLLSMK 28 1 P23921;H0YCY7 P23921 RRM1 Ribonucleoside-diphosphate reductase large subunit;Ribonucleoside-diphosphate reductase 0 269097000.0 109926000.0 105309000.0 53862000.0 False True 142301373.9654079 99448461.57594924 44059668.67079038 1.0 0.6988580560024965 0.30962222951902674 27.084374350713897 -7.108776617956953 0.3338789121549276 1.0499620273541526 5.4143161618622055e-12 0.9999223786821162 0.0024898654776238575 0.07722625507635193 0.01499885242056864 0.006842337076452898 0.034778043552335866 7.784368418715776e-08 7.108776617956953 -1.0499620273487382 down WFTLSSGQGQVLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WFTLSSGQGQVLLR 14 0 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 0 4555890.0 603390.0 1394700.0 2557800.0 False True 826479.5890016307 1333077.542343858 1953700.3195445572 1.0 1.6129588196535942 2.363882115836139 19.65661966514649 -6.9684032292508435 0.29383670460340344 0.8598475667230798 3.1403186661620888 0.9999671088256749 0.0031987447282412333 0.07682432310233028 0.01087514808667218 0.012855086296240062 0.0678004280235773 1.0754662121797614e-07 6.9684032292508435 2.280471099439009 WFVLGVGQVIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WFVLGVGQVIK 11 0 H7BZJ4;Q9Y680-1;Q9Y680-3;Q9Y680 H7BZJ4 FKBP7 Peptidyl-prolyl cis-trans isomerase;Peptidyl-prolyl cis-trans isomerase FKBP7 0 3457730.0 448230.0 1057300.0 1952200.0 False True 613952.7439602934 1010584.9899764558 1491130.5668210525 1.0 1.6460305779524527 2.428738337746544 19.22776808984036 -6.968562792715323 0.29046913022382104 0.8479197877414592 3.2510474385624266 0.9999689016080798 0.0032576674481650915 0.07677184017100518 0.010690788569786013 0.013639925425536662 0.07094099433711083 1.075071149379816e-07 6.968562792715323 2.4031276508209674 WGAK(ub)EVEDHYCDACQFSNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WGAKEVEDHYCDACQFSNR 19 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 27304500.0 11494100.0 9276700.0 6533700.0 True False 15068876.409022754 7892652.520293387 5857655.399675946 1.0 0.5237717999709336 0.38872542588301884 23.845068512496763 -13.999999999999998 0.17676880597352512 3.44714259147452 0.2777950004394982 0.9995023929417934 0.005848674403074677 12.164610428552704 0.1332477991548525 10.217421127992996 0.10366894479103184 1.0000000000000041e-14 13.999999999999998 -3.169347591035022 WGAK(ub)EVEDHYCDACQFSNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WGAKEVEDHYCDACQFSNR 19 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 37345700.0 19052800.0 8987000.0 9305900.0 True False 28904490.5462577 7383199.634248504 7466584.78607914 1.0 0.25543434583054486 0.2583191969472663 24.784790308686556 -10.402637741306648 8.890688930770727 1.000003631606759 0.25687677138895737 0.9999886970468573 0.0011777355366442907 8.477933875292432e-08 5.695588753127369e-09 0.0011403430970839804 0.0003801125099716661 3.956965453883914e-11 10.402637741306648 -0.7431268602178017 WGAK(ub)EVEDHYCDACQFSNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WGAKEVEDHYCDACQFSNR 19 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 25160800.0 11494100.0 12554600.0 1112100.0 True False 15743779.386373093 11999896.259489665 849444.8844184483 1.0 0.7621992130984815 0.05395431831023234 23.908278574019654 -7.264233030202112 0.7238019340207121 0.9941912650706592 1.245864527718014e-17 0.993805660397951 0.03162520370052789 0.0965997328629392 0.09572432435228315 0.02806098618146004 0.06316513617852113 5.442105664056739e-08 7.264233030202112 -0.9941912650706592 down WGAK(ub)EVEDHYCDACQFSNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WGAKEVEDHYCDACQFSNR 19 1 A0A0C4DFP4;Q96IV0-3;Q96IV0-5;Q96IV0-2;Q96IV0 A0A0C4DFP4 NGLY1 Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase 1 33208500.0 19052800.0 8165500.0 5990200.0 True False 24664225.186835878 7711082.746948628 4900045.06464239 1.0 0.3126424077195131 0.19867013974790126 24.555916630779006 -13.999999999999998 0.25284690936102017 5.849687297646412 0.1540688915542413 0.9995481126139675 0.007524321566963102 14.112688214995432 0.15911310796476272 34.82112959734299 0.05177806507872951 1.0000000000000041e-14 13.999999999999998 -5.69561840609217 WGDAGAEYVVESTGVFTTMEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WGDAGAEYVVESTGVFTTMEK 21 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 23769900.0 7744300.0 2442600.0 13583000.0 False True 7498461.435515506 3417942.9179907236 10025204.818734543 1.0 0.45581923003592084 1.336968244078904 22.838163177325004 -6.73968225421396 1.6882528527326264 0.6760843872796595 1.3374071968782075 0.6033254450316299 0.2286426696999229 0.31840264188031836 1.7818539945028402 0.10715381610492312 0.262997651161194 1.8210327057146076e-07 6.73968225421396 0.6613228095985481 WGDAGAEYVVESTGVFTTMEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WGDAGAEYVVESTGVFTTMEK 21 0 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 0 14154700.0 7744300.0 2669400.0 3741000.0 False True 6439728.580660603 2655019.4123655865 4523225.803570327 1.0 0.4122874712979329 0.7023938582061053 22.61856845275928 -10.50382249783482 6.331788053116795 1.0003194323136302 0.5573406647520386 0.7563529765004127 0.11843543650790944 0.0005344321272240704 4.187941067514711e-05 0.11475486951376103 0.03822487276632824 3.134566603292928e-11 10.50382249783482 -0.4429787675615916 WGFTK(ub)FNADEFEDMVAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WGFTKFNADEFEDMVAEK 18 1 F8W7C6;P27635;X1WI28;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 15433800.0 3553200.0 2207300.0 9673300.0 True False 3440405.610923347 3088686.400917436 7139572.537220421 1.0 0.8977680977820764 2.075212444297892 21.71414723261534 -6.885764216016175 1.0471640633527155 0.9301617516003656 2.1684450561855906 0.9780438379170135 0.07891772737882986 0.12264511639133445 0.24248814518458162 0.0577205745421204 0.1418638940297028 1.300875648241469e-07 6.885764216016175 1.238283304585225 up WGFTK(ub)FNADEFEDMVAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WGFTKFNADEFEDMVAEK 18 1 F8W7C6;P27635;X1WI28;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 62880100.0 6718100.0 21192000.0 34970000.0 True False 10191848.858898116 17410122.026148256 28058164.17210449 1.0 1.708239816659775 2.753000418330181 23.280912452478145 -6.9655333462177245 0.3487774439309791 0.8976056529281162 3.5988224930934116 0.9999237214444698 0.006288667312162255 0.07778043123579653 0.014224382785024487 0.014386161360105317 0.08987333542509769 1.0825965874593313e-07 6.9655333462177245 2.701216840165295 WGFTK(ub)FNADEFEDMVAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WGFTKFNADEFEDMVAEK 18 1 F8W7C6;P27635;X1WI28;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 13519800.0 3553200.0 3729600.0 6237000.0 True False 2954643.233449535 3709507.904532361 7541127.863370256 1.0 1.2554842028089883 2.5522972716289734 21.494552508049615 -6.939469520104658 0.6644788451966639 0.9853023578913426 2.896617542220745 0.9980936090141351 0.02967256228437747 0.08800944768385055 0.05571769250953551 0.02876924313603222 0.11187749453014191 1.1495569194278003e-07 6.939469520104658 1.9113151843294025 up WGFTK(ub)FNADEFEDMVAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WGFTKFNADEFEDMVAEK 18 1 F8W7C6;P27635;X1WI28;A0A087WV22 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 43410100.0 6718100.0 13725000.0 22967000.0 True False 8696712.883548994 12961191.684755348 18787241.661320455 1.0 1.490355247817045 2.1602692779313273 23.052038774570594 -6.966763536400348 0.3263709846993672 0.9148513109293809 2.757585514552306 0.999945018758593 0.0035262775583563065 0.0773674987367381 0.012776548013967416 0.009905535079067251 0.058605504140323575 1.0795343444671238e-07 6.966763536400348 1.8427342036229248 WGK(ub)QDGGEGHVGTVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WGKQDGGEGHVGTVR 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 172530000.0 40324000.0 78788000.0 53418000.0 True False 52865154.49817153 67033137.51321865 47890817.78163817 1.0 1.268002300372302 0.9059051890843256 25.655813762789304 -6.708470436622909 1.8006640060114831 1.1650234539015132 0.9067956427118681 0.45774744459459116 0.11296287679204578 0.37820227416238605 2.3894632847033996 0.04994108615960481 0.1271093816735148 1.9567239618895128e-07 6.708470436622909 -0.2582278111896451 WGK(ub)QDGGEGHVGTVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WGKQDGGEGHVGTVR 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 474346100.0 104456000.0 162443730.0 207446370.0 True False 101140101.45632364 227308358.52186108 153109942.4392984 1.0 2.2474602580858787 1.5138401112383442 26.591779889883195 -10.107113520279142 5.260323526439953 0.9999823016977771 1.8806501846629586 0.6576907497485801 0.29949917080331645 6.216559658524694e-05 1.0552138147658692e-05 0.28999464085180665 0.09666294172658754 7.814235215163166e-11 10.107113520279142 0.8806678829651815 WGK(ub)QDGGEGHVGTVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WGKQDGGEGHVGTVR 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 392949000.0 103549000.0 151591000.0 137809000.0 True False 157091403.44592074 124538401.66411106 110570990.74616964 1.0 0.7927766824426128 0.7038640455219696 27.22702899291193 -13.999999999999895 0.11546294721308495 1.9919428095767842 0.5528737565900076 0.9997154614729322 0.0020928622939292664 11.983371362747972 0.10396241701350137 2.7454213073812506 0.13399046973493214 1.0000000000002414e-14 13.999999999999895 -1.4390690529867767 WGK(ub)QDGGEGHVGTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WGKQDGGEGHVGTVR 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 173305740.0 40324000.0 63240740.0 69741000.0 True False 55232872.51512589 60446554.997638874 53269612.16098093 1.0 1.0943945560876844 0.964454856958466 25.719023824312195 -6.711897814080731 1.7885454995925112 1.0579200604972028 0.9647444635035438 0.4740231115939887 0.03976590233734651 0.37129456900710023 2.3164584464762563 0.01768597245644292 0.04482580476238293 1.9413426058049563e-07 6.711897814080731 -0.09317559699365896 WGK(ub)QDGGEGHVGTVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WGKQDGGEGHVGTVR 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 466362690.0 104456000.0 271913690.0 89993000.0 True False 86859792.18541165 270448836.9813285 108810120.2193812 1.0 3.1136251903990986 1.2527098843054356 26.37218516531747 -6.615461168031263 2.1325460238252356 2.4069278114621016 1.2595358557945247 0.06772531384790359 0.9099978277697318 0.5980157736458367 5.160924922434126 0.35132240379969915 1.0100513735368697 2.424034697290972e-07 6.615461168031263 -1.147391955667577 WGK(ub)QDGGEGHVGTVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WGKQDGGEGHVGTVR 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 343071000.0 103549000.0 210700000.0 28822000.0 True False 134046221.75594497 198974359.7798147 23576691.738693736 1.0 1.4843712651751049 0.175884791304445 26.99815531500438 -6.806456034915767 1.4291984959736064 1.265098719963565 0.15475766644869815 0.8504418485275449 0.20889324212161628 0.21165595901892714 0.8526930315530344 0.11494594025411266 0.2663678381031772 1.561507106560256e-07 6.806456034915767 -1.1103410535148668 down WGKQDGGEGHVGTVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WGKQDGGEGHVGTVR 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 0 581640.0 581640.0 0.0 0.0 False True 762535.6726097725 0.0 0.0 1.0 0.0 0.0 19.54044530510579 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 WGKQDGGEGHVGTVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WGKQDGGEGHVGTVR 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 0 7154600.0 1808000.0 2285600.0 3061000.0 False True 1750606.0296491622 3198251.999246545 2259232.2719683764 1.0 1.826939896858178 1.2905429512436601 20.739423014019177 -10.268475406267184 4.216203817687253 0.9995422246179985 1.55874142406798 0.5912914544466595 0.21898313612391032 154973851.08471742 536.7037470618025 692385.720720297 0.0749637520952452 5.3892036311803334e-11 10.268475406267184 0.5591991994499815 WGKQDGGEGHVGTVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WGKQDGGEGHVGTVR 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 0 2731300.0 581640.0 595760.0 1553900.0 False True 796688.0262299821 569437.353285135 1186900.823575062 1.0 0.7147557570053826 1.4897937266505823 19.603655366628683 -6.807081953552832 1.4267927032508234 0.8440006963896705 1.5024628385264427 0.852066463240713 0.12310191633680698 0.21080560627881229 0.8463409774395637 0.06785269703888017 0.15717285467804762 1.5592582351923364e-07 6.807081953552832 0.6584621421367722 WGKQDGGEGHVGTVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WGKQDGGEGHVGTVR 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 0 6413200.0 1808000.0 2823000.0 1782200.0 False True 1503432.1079806238 2807791.9386783717 2154849.7800382394 1.0 1.8675881163997055 1.433287056063067 20.519828289453454 -9.828227889709057 5.582730543240566 0.9999998131411821 1.6504375862360665 0.7494153912079391 0.17730266544558107 120097030.3487244 1.5548484632462507 288.60684625180244 0.0606954183539168 1.485156123722054e-10 9.828227889709057 0.6504377730948844 WGLGGTCVNVGCIPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WGLGGTCVNVGCIPK 15 0 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9;E9PKD3;A0A0B4J225;E9PIZ5;E9PKI4;E9PLT3;A0A096LPD9;E7EWK1;A0A096LPK7;A0A182DWF2;Q9NNW7-2;D3YTF8;A0A182DWF3;Q9NNW7 Q16881 TXNRD1;TXNRD2 Thioredoxin reductase 1, cytoplasmic;Thioredoxin reductase 2, mitochondrial 0 70979000.0 21345000.0 21062000.0 28572000.0 False True 27983501.705274057 17919631.69903297 25615643.52197697 1.0 0.640364164848449 0.9153837783335451 24.73807316912796 -9.7827101829251 5.798929332144516 1.0000000193919654 0.7778739715898215 0.4651782293199148 0.11227628705348876 2.8150337372473374e-08 5.8663145852360615e-09 0.1087110572007359 0.03623701582707256 1.6492626242905333e-10 9.7827101829251 -0.22212604780214384 WGLGGTCVNVGCIPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WGLGGTCVNVGCIPK 15 0 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9;E9PKD3;A0A0B4J225;E9PIZ5;E9PKI4;E9PLT3;A0A096LPD9;E7EWK1;A0A096LPK7;A0A182DWF2;Q9NNW7-2;D3YTF8;A0A182DWF3;Q9NNW7 Q16881 TXNRD1;TXNRD2 Thioredoxin reductase 1, cytoplasmic;Thioredoxin reductase 2, mitochondrial 0 15241700.0 13267000.0 1974700.0 0.0 False True 12845846.346988646 2763208.0079244636 0.0 1.0 0.21510517355458025 0.0 23.61479860936495 -9.331991268929466 0.4562305884480627 1.1730182691242026 4.629428567870547e-25 0.9973414066595092 0.022159671825891507 0.7701136545504429 0.20633185518316835 0.28587844430706255 0.04808869037499698 4.655954537751705e-10 9.331991268929466 -1.1730182691242026 WGLGGTCVNVGCIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WGLGGTCVNVGCIPK 15 0 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9;E9PKD3;A0A0B4J225;E9PIZ5;E9PKI4;E9PLT3;A0A096LPD9;E7EWK1;A0A096LPK7;A0A182DWF2;Q9NNW7-2;D3YTF8;A0A182DWF3;Q9NNW7 Q16881 TXNRD1;TXNRD2 Thioredoxin reductase 1, cytoplasmic;Thioredoxin reductase 2, mitochondrial 0 61002000.0 21345000.0 18102000.0 21555000.0 False True 29236823.32693587 17302193.784690987 16464152.939159824 1.0 0.5917945869567329 0.5631307052429122 24.801283230650853 -13.999999999999998 0.37714665147412635 6.948019034735824 0.5604856356337637 0.9998028790868662 0.002801382826113806 23.678631494631396 0.20000147967185378 114.21517936338624 0.00783640189502728 1.0000000000000041e-14 13.999999999999998 -6.387533399102061 WGLGGTCVNVGCIPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WGLGGTCVNVGCIPK 15 0 Q16881;Q16881-5;A0A182DWI3;Q16881-2;F8W809;Q16881-3;Q16881-6;Q16881-4;A0A087WSW9;A0A087WSY9;E9PIR7;Q16881-7;E2QRB9;E9PKD3;A0A0B4J225;E9PIZ5;E9PKI4;E9PLT3;A0A096LPD9;E7EWK1;A0A096LPK7;A0A182DWF2;Q9NNW7-2;D3YTF8;A0A182DWF3;Q9NNW7 Q16881 TXNRD1;TXNRD2 Thioredoxin reductase 1, cytoplasmic;Thioredoxin reductase 2, mitochondrial 0 47471000.0 12162000.0 20120000.0 15189000.0 False True 15743948.748860953 19000304.313098572 12424757.85230099 1.0 1.2068322004969185 0.7891767211958118 23.908294093616387 -6.77204658619591 1.5665302208271485 1.1183240638708039 0.7866391273689145 0.7383435550263446 0.08721975958913439 0.2631412065890978 1.2746776166894034 0.04387766257113443 0.10425600275415045 1.6902596100007407e-07 6.77204658619591 -0.33168493650188935 WGLVPSWFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WGLVPSWFK 9 0 Q96FZ2;E7EMP6;D6RAZ3 Q96FZ2 HMCES Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein 0 2955850.0 1284900.0 778460.0 892490.0 False True 1244111.5528186997 1089303.137615271 658720.0948739155 1.0 0.8755670945642375 0.5294702821314518 20.246684419328826 -6.953138351694479 0.5232595721392256 1.0057364174181744 0.3837696609922658 0.9994250973205652 0.004773156774432783 0.08224953384486387 0.03093269312326267 0.0053797447272361295 0.02859740845164404 1.1139396131631522e-07 6.953138351694479 -0.6219667564259086 WGLVPTHAYAVLDIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WGLVPTHAYAVLDIR 15 0 Q9Y6W3;H7C1B7 Q9Y6W3 CAPN7 Calpain-7 0 5683580.0 1938300.0 912280.0 2833000.0 False True 1611782.3312493619 907365.3665665978 3425367.2016879832 1.0 0.5629577573686764 2.125204585803366 20.62022549257544 -6.8320405560338555 1.3188425351287498 0.766790127702462 2.1690004333374744 0.9098827201938712 0.19755469034789383 0.17830560276218407 0.6058307001576835 0.11758924727504338 0.2705908041299614 1.4721750188351958e-07 6.8320405560338555 1.4022103056350124 up WGQK(ub)YMTAVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WGQKYMTAVVK 11 1 P13498;H3BR52;H3BPX1;H3BNP7 P13498 CYBA Cytochrome b-245 light chain 1 45219100.0 1373100.0 18015000.0 25831000.0 True False 2083093.0870563118 14800082.498162575 20725491.52787048 1.0 7.104858918751953 9.949383278477661 20.99029587977034 -8.670038684208645 0.39866121148562816 2.0637282627697226e-17 10.566416312498864 0.9970673585960204 0.20218417635532787 0.27051521041863147 0.1316061445497034 1.155563775412213 0.7100806493158447 2.137771661827773e-09 8.670038684208645 10.566416312498864 WGQK(ub)YMTAVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WGQKYMTAVVK 11 1 P13498;H3BR52;H3BPX1;H3BNP7 P13498 CYBA Cytochrome b-245 light chain 1 41188100.0 1373100.0 18229000.0 21586000.0 True False 1777505.0178474756 17214540.125421144 17657569.49106388 1.0 9.684664714065123 9.933906972846051 20.76142220186279 -9.888216758366843 0.8522059476214955 1.3241292178789603e-18 9.876982004755336 0.9998876265204165 0.04403486677942614 1.193780493339539 0.45893545804477 3.5229811958982205 0.034798996535434376 1.2935500635413324e-10 9.888216758366843 9.876982004755336 WGTLLAVGCNDGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WGTLLAVGCNDGR 13 0 Q15291-2;Q15291 Q15291-2 RBBP5 Retinoblastoma-binding protein 5 0 8479600.0 2653900.0 3520200.0 2305500.0 False True 3479288.6004041554 2994999.8816321283 2066948.9759176061 1.0 0.8608081207417597 0.594072298480071 21.730360922068456 -6.960872187179991 0.422963347724318 1.0114207885971038 0.4333486317892336 0.9998011879044618 0.0023747833546172038 0.07939104090962486 0.019991017399286246 0.0034574709813755687 0.022185955600688725 1.0942783648945356e-07 6.960872187179991 -0.5780721568078702 WGTLTDCVVMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 WGTLTDCVVMR 11 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 56946600.0 11888000.0 19093000.0 25965600.0 False True 15585283.123555772 16244398.82393109 23278928.79162274 1.0 1.042290903229029 1.4936481170777516 23.893681027531557 -6.925153354651808 0.7855370244544954 0.9917664966177084 1.5758285651604858 0.9954974527272274 0.014990906022088267 0.09523283350503982 0.0905830207120699 0.013282492311547484 0.0419805111086875 1.1880826269651733e-07 6.925153354651808 0.5840620685427773 WGTLTDCVVMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 WGTLTDCVVMR 11 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 50701000.0 11888000.0 20092900.0 18720100.0 False True 16283314.861120336 19205129.23966512 14298797.932561602 1.0 1.1794360916966116 0.8781257412581781 23.956891089054448 -6.745368838310995 1.6667537783213138 1.1060934786340266 0.8777239233452336 0.6288968512636006 0.07538960166567361 0.308195855710667 1.6829856534858418 0.0357520929347793 0.08723047943045188 1.7973438157263685e-07 6.745368838310995 -0.228369555288793 WHFIGHLQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WHFIGHLQK 9 0 H0YBG2;E5RFX7;E5RG77;O94903 H0YBG2 PROSC Proline synthase co-transcribed bacterial homolog protein 0 36181900.0 10165000.0 9471900.0 16545000.0 False True 13326413.43800003 8058729.441177022 14833082.110846588 1.0 0.6047185522698627 1.1130588271072483 23.667785221725055 -6.699193141750742 1.834064520406252 0.7543492879577782 1.1115087570208986 0.4136371265641521 0.16687809467615203 0.39718535496417584 2.5969831983189984 0.07260938117043181 0.18689636454374742 1.9989726781682619e-07 6.699193141750742 0.35715946906312035 WHFIGHLQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WHFIGHLQK 9 0 H0YBG2;E5RFX7;E5RG77;O94903 H0YBG2 PROSC Proline synthase co-transcribed bacterial homolog protein 0 22373700.0 5942300.0 1938400.0 14493000.0 False True 5753664.939150575 2712413.228622464 10696848.519319717 1.0 0.47142356346925257 1.8591365038539964 22.456049778461757 -6.803477648466453 1.4416569601011082 0.7096339747096053 1.8799814856135342 0.8421384838730213 0.22721180049101644 0.21583208080938776 0.8852061700133552 0.12396608895290995 0.28771264869215724 1.5722527084227665e-07 6.803477648466453 1.170347510903929 WHFIGHLQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WHFIGHLQK 9 0 H0YBG2;E5RFX7;E5RG77;O94903 H0YBG2 PROSC Proline synthase co-transcribed bacterial homolog protein 0 14923400.0 4634600.0 4353400.0 5935400.0 False True 7031027.034645099 3576501.7567305523 4762265.588421762 1.0 0.5086741580010268 0.6773214730872023 22.74530401104971 -10.076829041765837 5.59291609901914 1.000002794982067 0.5929978155440006 0.8859172905596648 0.06884997807565431 2.399502056687391e-06 3.960792437970032e-07 0.06666416247358661 0.022221234872754396 8.378590369784958e-11 10.076829041765837 -0.40700497943806635 WHFIGHLQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WHFIGHLQK 9 0 H0YBG2;E5RFX7;E5RG77;O94903 H0YBG2 PROSC Proline synthase co-transcribed bacterial homolog protein 0 25057300.0 10165000.0 5481600.0 9410700.0 False True 13923275.19879611 5239404.786772853 7188086.479450304 1.0 0.37630548214876075 0.5162640525895681 23.730995283247946 -10.029319550672467 7.4045911122309676 1.0000000359579282 0.44628476737020206 0.9542742812521254 0.05713784711822595 3.3865338713516845e-08 4.564702231846999e-09 0.055323485879274076 0.01844116086058618 9.34717662708507e-11 10.029319550672467 -0.5537152685877261 WHFIGHLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WHFIGHLQK 9 0 H0YBG2;E5RFX7;E5RG77;O94903 H0YBG2 PROSC Proline synthase co-transcribed bacterial homolog protein 0 13357100.0 5942300.0 3689600.0 3725200.0 False True 4941285.738525045 3669723.392471745 4504122.0966212815 1.0 0.7426656920203006 0.911528362244792 22.236455053896034 -10.638384161839522 4.648034383789838 1.003605783200712 0.8270970271325351 0.5829685677279164 0.06893789644235093 0.002625743603526185 0.0002042819477510889 0.06804047359865267 0.02224961040364417 2.2994069419022107e-11 10.638384161839522 -0.17650875606817684 WHFIGHLQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WHFIGHLQK 9 0 H0YBG2;E5RFX7;E5RG77;O94903 H0YBG2 PROSC Proline synthase co-transcribed bacterial homolog protein 0 35012600.0 4634600.0 15960000.0 14418000.0 False True 5999581.061623999 15071811.970032463 11794071.941172928 1.0 2.512144067264714 1.9658159161500595 22.51643033314216 -10.546754203056684 7.225162252668584 0.9993419031427211 2.238979991707386 0.8727316119272983 0.22303753372484073 0.0023653514701699285 0.00014838178864828681 0.2160438758657413 0.07198505447462361 2.839525655476955e-11 10.546754203056684 1.239638088564665 WHLNLNVRPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WHLNLNVRPK 10 1 Q9Y3P9-2;Q9Y3P9 Q9Y3P9-2 RABGAP1 Rab GTPase-activating protein 1 0 2331800.0 2331800.0 0.0 0.0 False True 3057012.381183324 0.0 0.0 1.0 0.0 0.0 21.543690964609446 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 WHPDK(ub)NPENK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WHPDKNPENK 10 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q7Z6W7;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJB7 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily B member 7 1 17031300.0 2515000.0 5210600.0 9305700.0 True False 3297189.3552946467 4433198.790759725 8342835.430577527 1.0 1.3445387307346686 2.530287020725865 21.65280531168585 -6.948330098021525 0.5768842761378962 0.9856545767254967 2.9475072357528522 0.9990636466852292 0.02005657304408504 0.08416328168286888 0.03879132422926426 0.02108556629455716 0.09896958095660989 1.1263410228237972e-07 6.948330098021525 1.9618526590273555 up WHPDK(ub)NPENK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WHPDKNPENK 10 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q7Z6W7;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJB7 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily B member 7 1 20929900.0 4372600.0 5570300.0 10987000.0 True False 4233794.206440229 7794549.838730751 8109175.097065184 1.0 1.8410318165380084 1.915344653438735 22.0135197147765 -11.08711302358868 0.4297555008738607 8.45577109376207e-20 1.9178889432145354 0.9996382698764199 0.007894718447911566 2.982856035852237 0.21045802938222538 2.9284127281060024 0.017562697335431796 8.18251813309399e-12 11.08711302358868 1.9178889432145354 WHPDK(ub)NPENK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WHPDKNPENK 10 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q7Z6W7;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJB7 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily B member 7 1 25859700.0 5538300.0 14409000.0 5912400.0 True False 8402006.003964731 11837601.371969165 4743811.548503022 1.0 1.4089017987351173 0.564604636828933 23.002302386080174 -6.774986692777489 1.5551369969002122 1.2330347537645459 0.558906703914643 0.7493550569885647 0.1725919113845965 0.258435711602931 1.234064251350279 0.08744052109809007 0.2072269927435189 1.6788554591650316e-07 6.774986692777489 -0.6741280498499028 WHPDK(ub)NPENK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WHPDKNPENK 10 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q7Z6W7;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJB7 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily B member 7 1 17726300.0 2515000.0 5945000.0 9266300.0 True False 3444863.465319451 5682330.242513978 7077790.785438955 1.0 1.6495081154071345 2.0545925424021454 21.71601537320874 -8.83404833691146 0.13084081313983134 1.3679602314451121e-15 2.9231094254424264 0.9999146328241031 0.004013357917046524 0.3525200502592528 0.03937072285947809 0.47558094792490596 0.34311360876527486 1.4653847347754687e-09 8.83404833691146 2.923109425442425 WHPDK(ub)NPENK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WHPDKNPENK 10 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q7Z6W7;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJB7 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily B member 7 1 16166000.0 4372600.0 5401800.0 6391600.0 True False 3636010.639024382 5372699.431226646 7728054.008580628 1.0 1.4776357839998657 2.125421176065158 21.793924990210776 -6.966877424128572 0.3242178990005475 0.9155643586575675 2.7085171138646698 0.999946779012898 0.003364561740027415 0.07732951816153606 0.012643631708223258 0.009656919884510007 0.05677252134313436 1.0792512886141158e-07 6.966877424128572 1.7929527552071023 WHPDK(ub)NPENK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WHPDKNPENK 10 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q7Z6W7;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJB7 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily B member 7 1 14822700.0 5538300.0 4681900.0 4602500.0 True False 7169438.526214169 4421348.149279129 3764892.225637976 1.0 0.6166937805677548 0.525130693550424 22.773428708172624 -13.999999999999995 0.201127757955793 3.139945952272324 0.4663218683765621 0.9994870122678249 0.004658918496848478 12.553449857925145 0.14219894929269614 10.572993316850937 0.057816252133074966 1.0000000000000123e-14 13.999999999999995 -2.673624083895762 WHPDK(ub)NPENKEEAER ddPTM_RPMI8226_Bortezomib_1h_R1 1 WHPDKNPENKEEAER 15 2 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q7Z6W7;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJB7 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily B member 7 1 29239100.0 5689700.0 9027400.0 14522000.0 True False 7459251.799133178 7680547.108529601 13019402.744860323 1.0 1.0296672260644344 1.7454033052448072 22.830599497416713 -6.915616319434171 0.8566089929228722 0.9815776082947139 1.8499362738120606 0.9928739012134552 0.029090400634268328 0.10082062892428191 0.11948844948924293 0.0244988757135018 0.07057332422389842 1.2144613011846643e-07 6.915616319434171 0.8683586655173468 WHPDK(ub)NPENKEEAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 WHPDKNPENKEEAER 15 2 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q7Z6W7;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJB7 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily B member 7 1 51749280.0 8440100.0 14861180.0 28448000.0 True False 8172173.645377164 20795326.67402991 20996615.378293496 1.0 2.5446506127281587 2.5692815999046794 22.962288428640413 -10.736822934156038 0.7385927469250997 3.0193240117983413e-09 2.5645810405578784 0.9999700037955422 0.004020187984810353 2.3826995062046645 0.38233002323579685 4.285371384914574 0.003714109573574238 1.8330616260791917e-11 10.736822934156038 2.5645810375385545 WHPDK(ub)NPENKEEAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 WHPDKNPENKEEAER 15 2 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q7Z6W7;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJB7 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily B member 7 1 85740000.0 18240000.0 34565000.0 32935000.0 True False 27671413.522618223 28396605.69242238 26425382.814076666 1.0 1.0262072687111337 0.9549704713305278 24.721893006387987 -6.807120327051665 1.4266004974058004 1.0143320320911302 0.9538045671983878 0.8521793320670439 0.011310755351863365 0.21075163552230158 0.8458848202618093 0.006235173533824515 0.014442986910608444 1.5591204679555493e-07 6.807120327051665 -0.06052746489274241 WHPDK(ub)NPENKEEAER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WHPDKNPENKEEAER 15 2 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q7Z6W7;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJB7 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily B member 7 1 29191300.0 5689700.0 8185600.0 15316000.0 True False 7793335.848361063 7823933.125840613 11698676.242921447 1.0 1.0039260822419176 1.5011128059342749 22.893809558939605 -6.908630571658271 0.9050093342252112 0.9839313019370503 1.5635188075673427 0.990394385354279 0.023062015291106564 0.1053307852267417 0.14373096106132555 0.018754226650934888 0.05129191426692665 1.2341542080186456e-07 6.908630571658271 0.5795875056302925 WHPDK(ub)NPENKEEAER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WHPDKNPENKEEAER 15 2 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q7Z6W7;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJB7 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily B member 7 1 35112600.0 8440100.0 15966500.0 10706000.0 True False 7018317.109827034 15880485.29539787 12944575.101048913 1.0 2.2627198296813984 1.844398721015889 22.74269370407469 -10.104770532407501 4.733291117371831 0.9999403659738606 2.053559275358936 0.8942627491953837 0.17077887752633703 0.00010992595182260583 2.0791243606670417e-05 0.16536543463565087 0.05511864570503888 7.856506381361704e-11 10.104770532407501 1.0536189093850754 WHPDK(ub)NPENKEEAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WHPDKNPENKEEAER 15 2 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;C9JB42;C9JN01;Q8WWF6;Q7Z6W7;O75190-2 O75190;O75190-2 DNAJB6;DNAJB3;DNAJB7 DnaJ homolog subfamily B member 6;DnaJ homolog subfamily B member 3;DnaJ homolog subfamily B member 7 1 101299000.0 18240000.0 35936000.0 47123000.0 True False 23612039.564152587 33936130.0097172 38547097.52281119 1.0 1.437238401939597 1.6325187588340637 24.493019328480436 -11.320845374601827 0.14600308540619827 2.487634707333589e-19 1.899118599559046 0.9996519243600932 0.004933734893288457 3.8743233292706534 0.09042099585469526 1.450716633422097 0.1934584866172353 4.776993225607172e-12 11.320845374601827 1.899118599559046 WIEQWIK(ub)DHNS ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WIEQWIKDHNS 11 1 Q9Y3D8;D6RDH4;Q9Y3D8-2 Q9Y3D8 AK6;TAF9 Adenylate kinase isoenzyme 6 1 13769300.0 4421900.0 3801800.0 5545600.0 True False 5724236.718680178 3590226.4879492074 4536357.702661156 1.0 0.6271974176457532 0.7924825484343512 22.448651903478982 -10.157652662804047 5.0197569323046345 1.000016671628376 0.7098399830412168 0.8042706613058873 0.0674773720858544 1.2951708148567282e-05 2.1733267602184474e-06 0.0653385437557996 0.021778228194194227 6.955804019259645e-11 10.157652662804047 -0.2901766885871593 WIGDK(ub)EATYGER ddPTM_RPMI8226_Bortezomib_8h_R1 1 WIGDKEATYGER 12 1 P31350;P31350-2;A0A286YFD6;C9JXC1 P31350 RRM2 Ribonucleoside-diphosphate reductase subunit M2 1 28228800.0 2113100.0 7370700.0 18745000.0 True False 3205727.188302887 6055340.997458052 15040042.533774618 1.0 1.8889133858779015 4.691616488344044 21.612220224751347 -6.950327581364462 0.5552351818673221 0.9623887201134563 5.7509960339129185 0.9992267438418946 0.043745476081497 0.08335445991234451 0.035419974808810636 0.04716721281591955 0.23274696483684051 1.1211724528744738e-07 6.950327581364462 4.788607313799462 WIGDK(ub)EATYGER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WIGDKEATYGER 12 1 P31350;P31350-2;A0A286YFD6;C9JXC1 P31350 RRM2 Ribonucleoside-diphosphate reductase subunit M2 1 38837600.0 2113100.0 6687500.0 30037000.0 True False 2735449.60542823 6315334.74621504 24570574.20564648 1.0 2.308700819668869 8.982279972143738 21.383346546843796 -6.939367147261077 0.6654256996300906 0.9242120942253594 10.74891100982331 0.9980798185073796 0.15317200423224633 0.08805656056968 0.05593350078085408 0.14839588653945732 0.5760018404296875 1.1498279274350154e-07 6.939367147261077 9.824698915597951 WIGLDLSNGKPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WIGLDLSNGKPR 12 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 168453000.0 47863000.0 58239000.0 62351000.0 False True 62748856.50595138 49549968.21384392 55899516.633024864 1.0 0.7896553176095628 0.8908451842102191 25.903085832785308 -10.081754212070358 4.532637414454824 1.0000107179000388 0.8402502509028489 0.7686851801253907 0.041310590076212475 9652676.794898598 21470042.107011404 608.7584512800424 0.014141713271335154 8.28410868230323e-11 10.081754212070358 -0.15976046699718993 WIGLDLSNGKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WIGLDLSNGKPR 12 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 120539500.0 44217500.0 23637000.0 52685000.0 False True 42813839.66593577 33075377.36532665 38885217.98387909 1.0 0.7725393850073814 0.9082394451721546 25.351573890510192 -10.2606291162098 5.1689507314932515 1.0000240596426055 0.8403894151592021 0.6484566333755448 0.055399317578246586 1.5362568869492578e-05 2.1974841500079986e-06 0.05364823972187634 0.01788005286429771 5.487453887676856e-11 10.2606291162098 -0.15963464448340348 WIGLDLSNGKPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WIGLDLSNGKPR 12 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 151681900.0 28652000.0 77890000.0 45139900.0 False True 43467178.74177951 63989920.94265229 36217978.979478955 1.0 1.4721434147541501 0.8332258965928051 25.373423124048134 -6.7087380307510545 1.7995554396670916 1.2906377590553517 0.8347742339762222 0.4591313599909813 0.19899878094153978 0.37764042806575576 2.3831106820459667 0.0880235024047944 0.22397633502753872 1.9555186816363766e-07 6.7087380307510545 -0.45586352507912953 WIGLDLSNGKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WIGLDLSNGKPR 12 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 217838000.0 47863000.0 59095000.0 110880000.0 False True 65559244.54894034 56483987.49896782 84692427.64528148 1.0 0.8615716652561823 1.2918456920603794 25.9662958943082 -6.8201156676052905 1.371237859369587 0.9253922839480687 1.3012713782840413 0.8846553463524389 0.06090890564312341 0.19334820179710116 0.7143059574681953 0.034903657256406706 0.0804501911921732 1.5131581885290728e-07 6.8201156676052905 0.37587909433597255 WIGLDLSNGKPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WIGLDLSNGKPR 12 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 102939500.0 44217500.0 25612000.0 33110000.0 False True 36768810.41738565 25474023.072416037 40033147.916656956 1.0 0.6928160792596917 1.0887800682756874 25.13197916594447 -6.6996127393011955 1.8322425173524624 0.8091787823901069 1.0875939175305303 0.4157415341402093 0.12967534440821088 0.396329712071225 2.586458619230614 0.05646786031021498 0.14529033492792948 1.9970422852785567e-07 6.6996127393011955 0.2784151351404234 WIGLDLSNGKPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WIGLDLSNGKPR 12 1 P17987;E7EQR6;F5H282 P17987 TCP1 T-complex protein 1 subunit alpha 0 140398000.0 28652000.0 75734000.0 36012000.0 False True 37090578.8153564 71519336.3244635 29458185.514323723 1.0 1.928234570846135 0.794222858073256 25.144549446140584 -6.689078250614831 1.8692032666198373 1.5824139874178733 0.798127200313858 0.36640404672003457 0.3926464425808613 0.4186136144364822 2.834882260205683 0.16807296088113455 0.43826165519101357 2.0460759442082525e-07 6.689078250614831 -0.7842867871040153 WIK(ub)QYTGINAISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WIKQYTGINAISK 13 1 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 10806200.0 2676600.0 5248400.0 2881200.0 True False 2591632.7980967676 7344113.490044424 2126527.2858527536 1.0 2.8337785721178417 0.8205357207295816 21.30542989021136 -6.666996477115929 1.9477353913725188 2.17352959596817 0.8287409309504812 0.2657763390232639 0.7794991143321499 0.4681517703628715 3.4209500508196102 0.32249939367632796 0.8651159951860761 2.1527991976016535e-07 6.666996477115929 -1.344788665017689 WIK(ub)QYTGINAISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WIKQYTGINAISK 13 1 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 34028100.0 9406300.0 5431800.0 19190000.0 True False 14270044.79264276 4462452.851152894 15397088.088724224 1.0 0.3127147052442058 1.0789796607129458 23.76648652754814 -6.670273858799799 1.9361775940942794 0.5614171293492636 1.0759010808516252 0.280345972581733 0.2919244735676279 0.4604955916013779 3.3283399551548087 0.12136334971484285 0.32416321380916996 2.136614351522845e-07 6.670273858799799 0.5144839515023616 WIK(ub)QYTGINAISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WIKQYTGINAISK 13 1 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 24725100.0 9406300.0 4383800.0 10935000.0 True False 12176640.775893016 4139837.676330096 8944942.202574963 1.0 0.3399819172235117 0.7345985126114517 23.53761284964059 -10.79111750178807 6.967460237058057 1.0162154193028348 0.5372902149177711 0.6470398812275651 0.16110155045579644 0.03933928849115344 0.0011793795645496283 0.1512194337088736 0.05199530183029112 1.6176423125793426e-11 10.79111750178807 -0.4789252043850637 WILHNCIIYNGGNHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WILHNCIIYNGGNHK 15 0 Q9ULU4-19;Q9ULU4-16;H7C4X9;A0A087WVZ6;Q9ULU4-22;Q9ULU4-7;Q9ULU4-11;Q9ULU4-10;Q9ULU4-13;Q9ULU4;Q9ULU4-20;Q9ULU4-5;A0A087WYS3;Q9ULU4-9;Q9ULU4-14;Q9ULU4-12;Q9ULU4-18;Q9ULU4-21;Q9ULU4-8;Q9ULU4-23;Q9ULU4-15;Q9ULU4-17;Q9ULU4-6;Q9ULU4-3;A0A087WV57 Q9ULU4-19 ZMYND8 Protein kinase C-binding protein 1 0 6691500.0 2110500.0 1775300.0 2805700.0 False True 2890808.884117973 1696861.3758679652 2143051.445205322 1.0 0.5869849733721507 0.7413328003034685 21.46304180247354 -10.20120353809188 4.870691005167779 1.0000431958988627 0.6641588868370559 0.8632489571747209 0.06301223648412721 2.956077655026152e-05 4.8480276818822695e-06 0.06101916843204586 0.020337111875487944 6.292112252357616e-11 10.20120353809188 -0.3358843090618068 WILSIGLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WILSIGLK 8 0 A0A2R8Y7R9;Q13136-2;Q13136 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 0 1846070.0 1025200.0 488330.0 332540.0 False True 992655.5871661088 683322.7156073089 245437.7980138398 1.0 0.6883784511384241 0.24725373149264188 19.920933720008208 -7.223651374572461 0.3923043038565224 1.0320691164470672 5.810305092366314e-15 0.999675931757714 0.005559335321112434 0.09191339374268831 0.026029783617599965 0.009523699664832038 0.04562229132278738 5.97514742931714e-08 7.223651374572461 -1.0320691164470615 down WILSIGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WILSIGLK 8 0 A0A2R8Y7R9;Q13136-2;Q13136 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 0 19798100.0 6497000.0 7414100.0 5887000.0 False True 9856423.994322952 6090995.928372308 4723431.86963624 1.0 0.6179721907134439 0.47922368927684283 23.232632887182298 -13.999999999999998 0.14089406318565045 2.8263743447773972 0.3093506984545168 0.9995993930386118 0.004407396870009081 11.935013400136704 0.11766783718594158 5.98996502565768 0.15195732782271343 1.0000000000000041e-14 13.999999999999998 -2.5170236463228806 WILSIGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WILSIGLK 8 0 A0A2R8Y7R9;Q13136-2;Q13136 A0A2R8Y7R9 PPFIA1 Liprin-alpha-1 0 20499300.0 6497000.0 8693700.0 5308600.0 False True 8410494.575016415 8209887.95262351 4342489.270835799 1.0 0.9761480587611563 0.5163179444565926 23.003759209274747 -6.917649652551282 0.8419723166180668 1.011030612060423 0.4460313729217092 0.9935027651170734 0.01794285044083404 0.09957465941677938 0.11292527329195352 0.015270182093367368 0.0447625260621851 1.2087885774523197e-07 6.917649652551282 -0.564999239138714 WIQSIMDMLQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WIQSIMDMLQR 11 0 O60934;A0A0C4DG07 O60934 NBN Nibrin 0 8815200.0 2757900.0 3138200.0 2919100.0 False True 2670351.974098139 4391299.625496805 2154500.1388771264 1.0 1.6444647252839706 0.8068225311776618 21.348598482704766 -6.7012279100438406 1.8269143844430409 1.399711423680997 0.8092901391828621 0.42325081228965045 0.27197624890184 0.392954142935308 2.550748252114886 0.11874030427821196 0.3048587090490794 1.9896289429787604e-07 6.7012279100438406 -0.590421284498135 WIQSIMDMLQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WIQSIMDMLQR 11 0 O60934;A0A0C4DG07 O60934 NBN Nibrin 0 3025090.0 0.0 790990.0 2234100.0 False True 0.0 756041.4463458594 1706451.5927337962 0.0 WIQSIMDMLQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WIQSIMDMLQR 11 0 O60934;A0A0C4DG07 O60934 NBN Nibrin 0 8043600.0 2757900.0 2147200.0 3138500.0 False True 2293316.0456857146 2135632.60741417 3794745.839215585 1.0 0.9312421684886454 1.6546981591806438 21.129003758139042 -6.883599826947056 1.0594723611000765 0.9549576519396503 1.7096540462210754 0.976476902987742 0.05000625081123954 0.12449116832720936 0.25339770352278995 0.036231464860970904 0.08847949837516937 1.3073749911116031e-07 6.883599826947056 0.7546963942814251 WISIMTER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WISIMTER 8 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 17035500.0 5928300.0 5696800.0 5410400.0 False True 8120152.716283613 5445096.53920162 4132574.950685698 1.0 0.6705657799122899 0.508928230179527 22.95307542985694 -13.999999998554944 0.09330837800751539 2.6641614752073797 0.12593934699583545 0.999826674099702 0.0026902386286777246 12.13464269180893 0.08954654375948944 3.9625411866755247 0.3431397092669144 1.0000000033273635e-14 13.999999998554944 -2.5382221282115442 WISIMTER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WISIMTER 8 0 P07355;P07355-2;H0YN42;H0YMU9;H0YMD0;A6NMY6;H0YM50;H0YNP5;H0YN28;H0YL33 P07355 ANXA2;ANXA2P2 Annexin A2;Annexin;Putative annexin A2-like protein 0 32523600.0 5808600.0 16491000.0 10224000.0 False True 7519347.204623723 15573261.353245927 8363336.907098908 1.0 2.0710922011514206 1.112242416729501 22.842175988470224 -6.619634532889793 2.1182970751876353 1.710888908832097 1.1159096463226401 0.08148816514288304 0.4606513689530993 0.5863927841106021 4.999534088947586 0.17872639404304796 0.5107326552035745 2.4008524323967737e-07 6.619634532889793 -0.594979262509457 WITAK(ub)EDDLNSFNATDLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WITAKEDDLNSFNATDLK 18 1 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 1 10549300.0 1832700.0 3589200.0 5127400.0 True False 2402687.447892045 3053705.350592022 4596865.833493799 1.0 1.2709540532503034 1.9132183994746288 21.196217557906998 -6.956592487546839 0.4810617428308379 0.9847368330253561 2.2262612633792243 0.9996221878127601 0.007443634556290128 0.08094162574315684 0.025805603339568266 0.009075335326553732 0.052979465619753606 1.1051150985164227e-07 6.956592487546839 1.2415244303538682 WITAK(ub)EDDLNSFNATDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WITAKEDDLNSFNATDLK 18 1 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 1 20742500.0 2542700.0 3931800.0 14268000.0 True False 2461983.380303611 5501788.24406613 10530782.769175027 1.0 2.234697556482957 4.277357375124268 21.23138959222108 -6.9635786584436605 0.3816680875018552 0.8622940549654639 5.722185312070109 0.9998807704951364 0.014756901665879969 0.07844673936100989 0.016581930664568416 0.026539374083966012 0.17246611056881045 1.0874801578232437e-07 6.9635786584436605 4.859891257104645 WITAK(ub)EDDLNSFNATDLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WITAKEDDLNSFNATDLK 18 1 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 1 12487300.0 1832700.0 3534300.0 7120300.0 True False 2510298.7168552494 3378142.9396328274 5438631.787181608 1.0 1.3457135268207288 2.1665277326017987 21.25942761942989 -6.956558117368624 0.48150044005539244 0.9805736708006291 2.565976183712412 0.9996204651372104 0.009530846191384295 0.08095438958371379 0.025854684731627244 0.011608697843274807 0.06770686943163623 1.1052025610735088e-07 6.956558117368624 1.585402512911783 up WITAK(ub)EDDLNSFNATDLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WITAKEDDLNSFNATDLK 18 1 P09960;P09960-2;P09960-4;P09960-3 P09960 LTA4H Leukotriene A-4 hydrolase 1 19329800.0 2542700.0 4456100.0 12331000.0 True False 2114367.7107092566 4432094.1048334 14909355.087897807 1.0 2.096179431035045 7.0514485311055575 21.011794867655357 -6.942076639537196 0.639952005820636 0.9457552358847419 8.473527878239866 0.9984234542709987 0.10453023867574747 0.08683188542572381 0.05039024718041209 0.10343121897344704 0.42274180160719277 1.1426766699233722e-07 6.942076639537196 7.5277726423551234 WITGLSWEPLHANPECR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WITGLSWEPLHANPECR 17 0 Q9NVX2;A0A0A0MRH0 Q9NVX2 NLE1 Notchless protein homolog 1 0 11238300.0 2726300.0 3785000.0 4727000.0 False True 3734286.7854872383 3617766.18467879 3610579.9556208984 1.0 0.9687970936615558 0.9668727023465074 21.832401297132662 -13.999999999996401 0.3962696799529302 1.5135371916822846 0.9667497195654899 0.9998322821353844 0.00019654556478361016 26.229170582956186 0.20705183868369742 11.565242567198606 0.0004975736356607033 1.0000000000082868e-14 13.999999999996401 -0.5467874721167947 WITPAFQIHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WITPAFQIHK 10 0 Q9UNI6 Q9UNI6 DUSP12 Dual specificity protein phosphatase 12 0 6363800.0 1556700.0 1692400.0 3114700.0 False True 2040848.7751042426 1439900.5169235296 2792420.722312112 1.0 0.7055400353463143 1.3682643988011707 20.9607378533655 -6.785916914114224 1.5124980986670695 0.834544147894974 1.374550646289409 0.7878321915697886 0.1248800050536296 0.2415076086763311 1.0914615002327304 0.06500301886886485 0.15265996693356373 1.6371296945532383e-07 6.785916914114224 0.540006498394435 WITPAFQIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WITPAFQIHK 10 0 Q9UNI6 Q9UNI6 DUSP12 Dual specificity protein phosphatase 12 0 6303100.0 1556700.0 2113400.0 2633000.0 False True 2132254.0582356993 2020022.9999207822 2011139.628337176 1.0 0.9473650628632027 0.9431988747163003 21.023947914888392 -13.999999999999993 0.3595706264583863 1.6868484536699153 0.9426941441042255 0.9997724624149431 0.0003898928437980696 21.65128659492965 0.19376594647840803 11.409542364305574 0.001203933858306445 1.0000000000000164e-14 13.999999999999993 -0.7441543095656898 WIVNLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WIVNLIR 7 0 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 33588000.0 11905000.0 11475000.0 10208000.0 False True 15607570.28818401 9762974.729199678 9151774.082050301 1.0 0.6255281603050612 0.5863676352608718 23.895742627150657 -13.999999999999998 0.3189918088240961 4.816700070625043 0.5785053132924746 0.999691560782526 0.003274417307271208 17.935684638977413 0.18007539771406103 45.660630722437936 0.013089683882081577 1.0000000000000041e-14 13.999999999999998 -4.238194757332568 WIVNLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WIVNLIR 7 0 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 14485200.0 3769500.0 3591700.0 7124000.0 False True 5718607.087363463 2950733.0729198162 5715938.277439875 1.0 0.5159880767888598 0.9995333111922508 22.447232353937697 -10.941230411829036 10.392615328359113 1.0593574028980834 0.7577606939905572 0.2507238541039868 0.19740651530713227 0.11225579724782553 0.0006347987626686641 0.07903015418363003 0.06371267885144682 1.1449053589416576e-11 10.941230411829036 -0.3015967089075262 WIVNLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WIVNLIR 7 0 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 36299600.0 11905000.0 9261600.0 15133000.0 False True 16306600.220528064 8852391.887984429 11558897.073918153 1.0 0.5428717064419304 0.7088477621084301 23.95895268867355 -10.174008988146404 6.261045928553331 1.0000025203798566 0.6258597342751793 0.8713845606077038 0.06775944098378721 2.3839578418820097e-06 3.1448070488444905e-07 0.06560823940099535 0.021869265539877142 6.698707456469199e-11 10.174008988146404 -0.3741427861046773 WIVNLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WIVNLIR 7 0 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 19913000.0 9453400.0 4674200.0 5785400.0 False True 7860920.956628349 4649019.156843947 6995100.391332749 1.0 0.5914089688084043 0.8898576171834501 22.906266912562142 -10.491835916220655 5.535671856669988 1.0003989188983164 0.7406332929959268 0.5017430263350171 0.12184115049036474 0.0006007681081041645 5.5149352961299914e-05 0.11815056808708192 0.03932406222766093 3.22228599531955e-11 10.491835916220655 -0.2597656259023896 WIVNLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WIVNLIR 7 0 P60228;E5RGA2;H0YAW4 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 23850100.0 3769500.0 12796000.0 7284600.0 False True 4879692.057953581 12083891.351411989 5958877.546307965 1.0 2.476363509807147 1.221158523025112 22.218358676030146 -6.606587856290074 2.1668985119427635 1.9886324595417328 1.2255595356259121 0.039802487426180644 0.6370668225209937 0.622065860578453 5.530140569802894 0.24324292209860074 0.707456669878337 2.474070914611841e-07 6.606587856290074 -0.7630729239158207 WK(ub)AGLYGLPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WKAGLYGLPR 10 1 P49327;A0A0U1RQF0;A0A0U1RRG3 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 12387000.0 1836800.0 3675200.0 6875000.0 True False 1778491.7894134854 5142726.525914815 5074231.254420962 1.0 2.891622304093287 2.8531091819627417 20.762222883392315 -10.095578177231852 4.800677173848649 0.9999147778960068 2.8723657430473497 0.9996827806889169 0.015722916336769824 1.4342022228091501e-05 2.701929778013439e-06 0.01522432709607641 0.005074549417718871 8.024570977861916e-11 10.095578177231852 1.872450965151343 WK(ub)AGLYGLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WKAGLYGLPR 10 1 P49327;A0A0U1RQF0;A0A0U1RRG3 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 41559900.0 6129600.0 9758300.0 25672000.0 True False 9299051.333785132 8016855.123054098 20597917.94756267 1.0 0.862115374492817 2.2150558383011303 23.1486521128724 -6.881785233309577 1.0698360395233093 0.9123553253796227 2.314264898116463 0.9750953389816959 0.09593310071305972 0.1260584940288106 0.2628532814061745 0.06896297632539573 0.16754665651033795 1.312848966724525e-07 6.881785233309577 1.4019095727368405 up WK(ub)AGLYGLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WKAGLYGLPR 10 1 P49327;A0A0U1RQF0;A0A0U1RRG3 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 10757900.0 1836800.0 3866800.0 5054300.0 True False 1527380.5840369526 3845968.7809002977 6111130.7615572065 1.0 2.5180160210857117 4.001053061317006 20.54262815882659 -6.971411225653151 0.22190700784189402 0.332345928278992 6.228693252403149 0.9999913960585973 0.003593817702950038 0.07584740348708924 0.007369800240006723 0.04048577416663087 0.1497123591571768 1.0680430894360413e-07 6.971411225653151 5.896347324124157 WK(ub)AGLYGLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WKAGLYGLPR 10 1 P49327;A0A0U1RQF0;A0A0U1RRG3 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 32942100.0 6129600.0 5626500.0 21186000.0 True False 7934888.032479704 5313380.3289089985 17330365.38671727 1.0 0.6696225967096012 2.1840718250565434 22.91977843496485 -6.84955687940323 1.23723199429325 0.8237649146574028 2.2440963834292758 0.9396583296667553 0.1597163703214167 0.15794444776658417 0.46547553791425805 0.10102600213895786 0.23371436365364062 1.4139795245165688e-07 6.84955687940323 1.4203314687718729 up WK(ub)DSDEADLVLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WKDSDEADLVLAK 13 1 Q13185 Q13185 CBX3 Chromobox protein homolog 3 1 13946200.0 4333700.0 4762200.0 4850300.0 True False 4196129.065647447 6663771.294544926 3579860.924118983 1.0 1.5880758647533955 0.8531341310319358 22.000627622717396 -6.693647209605903 1.8536221956064902 1.3674271327753424 0.855570333875764 0.38743720114521607 0.24853494374297727 0.4088962888269836 2.726704798521857 0.10715517651992762 0.2777464865813627 2.0246632053058303e-07 6.693647209605903 -0.5118567988995785 WK(ub)QLSLPQQEAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WKQLSLPQQEAQK 13 1 O95782;O95782-2 O95782 AP2A1 AP-2 complex subunit alpha-1 1 9154300.0 3913700.0 4201000.0 1039600.0 True False 3254414.9563073963 4178368.379166784 1256975.553432698 1.0 1.2839076870233372 0.3862370257967712 21.63396678383777 -6.821663977093869 1.36467762130236 1.1527710810001877 0.3659342260641158 0.8881665345414638 0.12528155779265135 0.19132604401499992 0.6996846079171979 0.07213320329188731 0.16618469815400103 1.5077732112941512e-07 6.821663977093869 -0.7868368549360718 down WKDSDEADLVLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WKDSDEADLVLAK 13 1 Q13185 Q13185 CBX3 Chromobox protein homolog 3 0 21658100.0 1850000.0 9003500.0 10804600.0 False True 2425367.9154254845 7660212.895368123 9686643.637041587 1.0 3.1583714976390644 3.993886278215341 21.209772182396634 -9.319300165598127 0.30616661957033564 2.928477862379141e-22 4.320485880495935 0.9986232399833395 0.04680362460853134 0.714821333584359 0.11759551641556083 1.053989371569403 0.2836318285550431 4.79401992143684e-10 9.319300165598127 4.320485880495935 WKDSDEADLVLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WKDSDEADLVLAK 13 1 Q13185 Q13185 CBX3 Chromobox protein homolog 3 0 18995100.0 5990500.0 2474500.0 10530100.0 False True 5800334.8565339185 3462580.7543470324 7771950.913771371 1.0 0.5969622168359004 1.3399141784058348 22.46770475954989 -6.7593726250988 1.6147166808500728 0.7657103187882524 1.3425548674165977 0.6884349650382945 0.16950454519478292 0.28397846381725805 1.4591353187609468 0.08282949291094421 0.19918496197840815 1.7403130423022413e-07 6.7593726250988 0.5768445486283453 WKDSDEADLVLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WKDSDEADLVLAK 13 1 Q13185 Q13185 CBX3 Chromobox protein homolog 3 0 29467300.0 1850000.0 14143700.0 13473600.0 False True 2533994.994370172 13518784.567038666 10291413.177502371 1.0 5.334968931301611 4.0613391898433155 21.272982243919525 -9.672230365662719 6.248739515324989 0.9999999897470215 4.698154060587444 0.9183103339893547 0.519957164687932 1.3495716125648447e-07 3.121434616666571e-08 0.5034463598706967 0.16781545329024491 2.1270105026053612e-10 9.672230365662719 3.6981540708404226 WKDSDEADLVLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WKDSDEADLVLAK 13 1 Q13185 Q13185 CBX3 Chromobox protein homolog 3 0 8316950.0 5990500.0 1521600.0 804850.0 False True 4981366.174147093 1513402.838786048 973140.4137940605 1.0 0.3038128067437589 0.19535612917688813 22.248110034984165 -13.999999999999998 0.26172571018428226 6.14260439393801 0.15636628115328324 0.9995658754790298 0.007428106735805996 14.49406653469216 0.16189814601976366 39.463260726424096 0.046988567922270526 1.0000000000000041e-14 13.999999999999998 -5.986238112784727 WKDSDEADLVLAK(ub)EANMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WKDSDEADLVLAKEANMK 18 2 Q13185 Q13185 CBX3 Chromobox protein homolog 3 1 45422300.0 13696300.0 19484000.0 12242000.0 True False 17955981.935157858 16577063.148037158 10975315.273555994 1.0 0.9232056040098384 0.6112344795840042 24.097961214136816 -6.9445196988837035 0.6160897012529853 1.0034255608882077 0.5145975753217849 0.9986978897368827 0.006066365012590958 0.08576406036041309 0.045666518287801286 0.006131276439843934 0.026363789351859093 1.136266757306378e-07 6.9445196988837035 -0.4888279855664228 WKDSDEADLVLAK(ub)EANMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 WKDSDEADLVLAKEANMK 18 2 Q13185 Q13185 CBX3 Chromobox protein homolog 3 1 78178600.0 32694600.0 29553800.0 15930200.0 True False 31656727.819119237 41354786.461031 11757602.724243898 1.0 1.3063506341313826 0.37140928751147917 24.916008803985413 -6.818433989776772 1.3787091137728629 1.1653769376410876 0.35168408365731263 0.8807578032164974 0.13438672304271634 0.19550215827954398 0.7306411498022548 0.07660762381136033 0.17663998697298555 1.5190288079878237e-07 6.818433989776772 -0.813692853983775 down WKDSDEADLVLAK(ub)EANMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WKDSDEADLVLAKEANMK 18 2 Q13185 Q13185 CBX3 Chromobox protein homolog 3 1 135483000.0 43088000.0 57213000.0 35182000.0 True False 65367646.15474638 47002893.14279069 28228262.279181626 1.0 0.7190543932317774 0.4318384390399524 25.962073411837554 -6.970849591559902 0.23701894768797044 1.1070200053524382 0.03559600662194267 0.9999882708986269 0.0007943756781999554 0.07602798805955499 0.008037212352871895 0.007012866064225764 0.028151576163486642 1.06942518722928e-07 6.970849591559902 -1.0714239987304954 down WKDSDEADLVLAK(ub)EANMK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 WKDSDEADLVLAKEANMK 18 2 Q13185 Q13185 CBX3 Chromobox protein homolog 3 1 58455000.0 17504400.0 28587600.0 12363000.0 True False 23976249.718623377 27324505.30544873 9443114.02397739 1.0 1.1396488452580897 0.3938528391553463 24.515102679282744 -6.858293950808317 1.194336277395608 1.075448233941488 0.35889734030627146 0.9515369854314077 0.07126384395230692 0.14856344337424074 0.40365804177125675 0.04657019869789137 0.10850773878236264 1.3858175252767277e-07 6.858293950808317 -0.7165508936352165 down WKDSDEADLVLAK(ub)EANMK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 WKDSDEADLVLAKEANMK 18 2 Q13185 Q13185 CBX3 Chromobox protein homolog 3 1 75900600.0 32694600.0 33605500.0 9600500.0 True False 27187008.516362485 33424460.501330484 11607920.162303377 1.0 1.2294276687784165 0.4269657014789677 24.69641407941969 -6.830281426280404 1.3266520507479167 1.1225661531493916 0.40524708870040266 0.906439560429911 0.10322296564559619 0.18046158687514394 0.6210705683237141 0.06108950062322057 0.14058306527003733 1.478150224644201e-07 6.830281426280404 -0.7173190644489889 down WKDSDEADLVLAK(ub)EANMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 WKDSDEADLVLAKEANMK 18 2 Q13185 Q13185 CBX3 Chromobox protein homolog 3 1 186763000.0 56881000.0 65586000.0 64296000.0 True False 73633575.79213627 61936081.445272535 52594787.73267126 1.0 0.8411391240881042 0.7142772460371013 26.13386042754902 -6.973668897555496 0.14599019251714748 1.1560282792178005 0.3960627686579651 0.9999987057953128 0.0001328516420409154 0.07512911025526169 0.004445440075677284 0.006741298062793351 0.01609249993957399 1.0625052935522152e-07 6.973668897555496 -0.7599655105598354 WKDTDEADLVLAK(ub)EANVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WKDTDEADLVLAKEANVK 18 2 P45973 P45973 CBX5 Chromobox protein homolog 5 1 32582800.0 14104200.0 15215900.0 3262700.0 True False 18490742.78526711 12945747.031113671 2925107.102028357 1.0 0.7001204430483164 0.15819305562775973 24.140299844123863 -7.287853901139885 0.5127140851626532 1.0096572379431477 2.9274438866134495e-24 0.9984571420280829 0.013683686008978449 0.09853767237614207 0.04886339226400468 0.0147782017297131 0.05571479492907751 5.154019992605742e-08 7.287853901139885 -1.0096572379431477 down WKDTDEADLVLAK(ub)EANVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WKDTDEADLVLAKEANVK 18 2 P45973 P45973 CBX5 Chromobox protein homolog 5 1 39703800.0 22245000.0 13164100.0 4294700.0 True False 21538844.651297394 18420593.77987459 3169789.2317617075 1.0 0.855226641822918 0.1471661680595656 24.36043752966714 -7.0035620870190405 0.696096626117456 1.0047611978368656 5.691520437419493e-26 0.9980485517176779 0.01646071690151827 0.0781554309561623 0.05806818043822064 0.016030340160368313 0.053284223001555095 9.918315362275326e-08 7.0035620870190405 -1.0047611978368656 down WKDTDEADLVLAK(ub)EANVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WKDTDEADLVLAKEANVK 18 2 P45973 P45973 CBX5 Chromobox protein homolog 5 1 49917000.0 21632000.0 15521000.0 12764000.0 True False 32817325.51103495 12751156.283873493 10241189.80534006 1.0 0.3885495263648425 0.31206655770581976 24.967954333618067 -13.999999999999998 0.29314428576266677 6.363342811438361 0.29187717488391657 0.9996345013814629 0.00588557961245295 16.155404308648837 0.17176891637394143 52.34867144352287 0.028481544200951624 1.0000000000000041e-14 13.999999999999998 -6.071465636554445 WKDTDEADLVLAK(ub)EANVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WKDTDEADLVLAKEANVK 18 2 P45973 P45973 CBX5 Chromobox protein homolog 5 1 49896000.0 21632000.0 15050000.0 13214000.0 True False 28003050.430468686 14212454.269986749 10809187.587089686 1.0 0.5075323599218643 0.3860003614223671 24.739080655710517 -13.999999999999998 0.19651754713072758 3.7020959344489834 0.3043073944966222 0.9994871239690721 0.006012134183523517 12.46418668756335 0.14057570073192632 12.927250388745344 0.07944389516224436 1.0000000000000041e-14 13.999999999999998 -3.3977885399523613 WKGDNSSVSSLCISPDGK(ub)MLLSAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WKGDNSSVSSLCISPDGKMLLSAGR 25 2 Q15061;C9JEE7 Q15061 WDR43 WD repeat-containing protein 43 1 9367000.0 3134100.0 3219500.0 3013400.0 True False 4108835.4506675745 2739163.1495127063 2701602.2745738965 1.0 0.6666519461293263 0.6575104569191155 21.970298124395487 WKGDNSSVSSLCISPDGK(ub)MLLSAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WKGDNSSVSSLCISPDGKMLLSAGR 25 2 Q15061;C9JEE7 Q15061 WDR43 WD repeat-containing protein 43 1 22657800.0 11170000.0 4213600.0 7274200.0 True False 10815414.464148868 5896112.453633717 5368868.798677674 1.0 0.5451582528971273 0.49640897410584656 23.366585616974668 -13.999999999999998 0.3154313232589018 5.53921006291479 0.48622963216008575 0.9996838652016465 0.004032180337180537 17.66570575458801 0.17891430733378602 52.787989481195524 0.016526185109259562 1.0000000000000041e-14 13.999999999999998 -5.052980430754704 WKGDNSSVSSLCISPDGK(ub)MLLSAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WKGDNSSVSSLCISPDGKMLLSAGR 25 2 Q15061;C9JEE7 Q15061 WDR43 WD repeat-containing protein 43 1 138839500.0 26949000.0 24531000.0 87359500.0 True False 40883603.235802546 20153251.388422206 70092856.533971 1.0 0.49294215268123975 1.7144490941686215 25.28501901658639 -6.793980934811782 1.4804875244101798 0.7180613046748049 1.7288829607777174 0.8139225586920159 0.21614427334682348 0.22947657649694397 0.9935208057626996 0.1148925981754865 0.2682215343303735 1.607011798025979e-07 6.793980934811782 1.0108216561029124 WKGDNSSVSSLCISPDGK(ub)MLLSAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WKGDNSSVSSLCISPDGKMLLSAGR 25 2 Q15061;C9JEE7 Q15061 WDR43 WD repeat-containing protein 43 1 17615100.0 3134100.0 3251000.0 11230000.0 True False 4292861.465867869 3107360.070380648 8577705.289109936 1.0 0.7238435470342967 1.9981323313855923 22.03350818591838 -6.849963830179163 1.2352771080968992 0.8526404684046117 2.0490353922099804 0.9402543025705415 0.13378874703851767 0.15749367459559221 0.46247893800003936 0.08475155267078603 0.1961142183306471 1.4126551914261223e-07 6.849963830179163 1.1963949238053688 WKGDNSSVSSLCISPDGK(ub)MLLSAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WKGDNSSVSSLCISPDGKMLLSAGR 25 2 Q15061;C9JEE7 Q15061 WDR43 WD repeat-containing protein 43 1 27294500.0 11170000.0 2117500.0 14007000.0 True False 9288349.91490242 2106092.6072091595 16935798.938949395 1.0 0.22674561429152243 1.823337739653547 23.146990892408944 -6.77502615693544 1.5553790217342627 0.5593328810619523 1.8340412863229612 0.7493542647687584 0.32637713864975504 0.25837873709146947 1.234243645150925 0.1653399770942692 0.39176514283494346 1.6787029092027247e-07 6.77502615693544 1.2747084052610087 WKGDNSSVSSLCISPDGK(ub)MLLSAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WKGDNSSVSSLCISPDGKMLLSAGR 25 2 Q15061;C9JEE7 Q15061 WDR43 WD repeat-containing protein 43 1 134564900.0 26949000.0 20857000.0 86758900.0 True False 34886011.74420767 19696289.6152235 70969670.421489 1.0 0.5645898923511596 2.0343302909445504 25.05614533867884 -6.827344384535324 1.339764907360551 0.7668871715355612 2.071769681332759 0.900455456160777 0.19447888665185895 0.1841086977884867 0.6472453112657189 0.11400433291887362 0.262397832419869 1.488180520199136e-07 6.827344384535324 1.3048825097971977 up WKPPMIDNPSYQGIWKPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WKPPMIDNPSYQGIWKPR 18 2 P27824;P27824-2;P27824-3 P27824 CANX Calnexin 0 31007300.0 7833800.0 6657500.0 16516000.0 False True 10270187.662627116 5664226.950731749 14807082.75265895 1.0 0.5515212707693443 1.441753864590172 23.291959207841153 -6.769739180471803 1.5753878041307352 0.7426763647787024 1.4467182237309564 0.7295688853827225 0.18899935630096504 0.26686029402343064 1.3070343129552577 0.09456420672133074 0.22516184393802693 1.6992638545542368e-07 6.769739180471803 0.704041858952254 WKPPMIDNPSYQGIWKPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WKPPMIDNPSYQGIWKPR 18 2 P27824;P27824-2;P27824-3 P27824 CANX Calnexin 0 16057800.0 4913000.0 2004600.0 9140200.0 False True 4757039.504240237 2805047.2338509 6746107.419877602 1.0 0.5896623795851583 1.4181314689239786 22.18163257535501 -6.772041519775368 1.5667635913532414 0.7652561044349814 1.4231416218525166 0.7382724096447587 0.17303415767585387 0.2631369224389999 1.2750704071302825 0.08703960023384856 0.20679423895033947 1.690279328455192e-07 6.772041519775368 0.6578855174175352 WKPPMIDNPSYQGIWKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WKPPMIDNPSYQGIWKPR 18 2 P27824;P27824-2;P27824-3 P27824 CANX Calnexin 0 21940300.0 7833800.0 7950400.0 6156100.0 False True 10730167.560484894 7599125.039543002 4702155.968859283 1.0 0.7082018986849447 0.4382183169418087 23.355169269364044 -7.0128308056412445 0.20674850503129014 1.1498525588528792 2.0903932040126867e-09 0.9999942447606079 0.0005503118448432625 0.07245089009919814 0.006663655688857621 0.008367028161552634 0.027386945686488622 9.708881364564487e-08 7.0128308056412445 -1.149852556762486 down WKPPMIDNPSYQGIWKPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WKPPMIDNPSYQGIWKPR 18 2 P27824;P27824-2;P27824-3 P27824 CANX Calnexin 0 11406700.0 4913000.0 3212400.0 3281300.0 False True 4085377.18280355 3195094.1635885234 3967404.658982977 1.0 0.7820805816994164 0.9711232235013327 21.962037850789287 -10.192021554419323 6.506329325448356 1.0000006828646282 0.8766019026535735 0.3622915887191376 0.07717633534040501 7.644996477802432e-07 9.48131210934471e-08 0.07472607958957107 0.024908555124558928 6.426558209486026e-11 10.192021554419323 -0.12339878021105466 WLAGLPLQLAHLGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WLAGLPLQLAHLGSR 15 0 Q9NXF1-2;Q9NXF1 Q9NXF1-2 TEX10 Testis-expressed sequence 10 protein 0 3123600.0 1789000.0 1334600.0 0.0 False True 1732209.17424909 1867512.7398470582 0.0 1.0 1.0781104081478048 0.0 20.7241817236559 -6.972124107616232 1.1661215911114933 1.049996478667536 2.8277979349430363e-21 0.9780307526377008 0.07275424944230686 0.09947501082704656 0.26715327606739275 0.05223140771013895 0.09756839780462573 1.066291365366573e-07 6.972124107616232 -1.049996478667536 down WLAGLPLQLAHLGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WLAGLPLQLAHLGSR 15 0 Q9NXF1-2;Q9NXF1 Q9NXF1-2 TEX10 Testis-expressed sequence 10 protein 0 3937550.0 1789000.0 897150.0 1251400.0 False True 1487632.766137909 892316.8748796679 1513061.9541801442 1.0 0.5998233537139951 1.0170937267725373 20.504586999090176 -10.978373385180488 12.220120273772167 1.104227650810232 0.8084585402645645 0.2193294769864088 0.17034991646236822 0.07833397092619171 0.0001386318251436032 0.026710113148910863 0.0549801991238814 1.0510578370708886e-11 10.978373385180488 -0.29576911054566746 WLEK(ub)NHIPITEQGDAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WLEKNHIPITEQGDAPR 17 1 Q8WXD5 Q8WXD5 GEMIN6 Gem-associated protein 6 1 7071400.0 2321700.0 2810200.0 1939500.0 True False 3043771.1833747793 2390929.114073805 1738819.1449977004 1.0 0.7855153919365463 0.5712713079403642 21.53742847710836 -6.97113946007713 0.22935291776799663 1.0878404541977793 0.26282947047178035 0.9999899544667404 0.0005547150169721224 0.07593475523253437 0.007694537082404661 0.005531263148405731 0.02130550885139675 1.0687116408283959e-07 6.97113946007713 -0.8250109837259989 WLEK(ub)NHIPITEQGDAPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WLEKNHIPITEQGDAPR 17 1 Q8WXD5 Q8WXD5 GEMIN6 Gem-associated protein 6 1 18628800.0 4492800.0 6369600.0 7766400.0 True False 6815906.067676488 5232895.11408805 6231367.635865948 1.0 0.7677475396711153 0.9142390716646412 22.70047402275308 -10.458696379519246 5.413337582501538 1.0001867050980253 0.8409933056678773 0.611028950406448 0.05980491750379243 0.00013491718038695193 1.3490955492205854e-05 0.05797354231321109 0.019301954126124263 3.477792130919031e-11 10.458696379519246 -0.15919339943014799 WLEK(ub)NHIPITEQGDAPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WLEKNHIPITEQGDAPR 17 1 Q8WXD5 Q8WXD5 GEMIN6 Gem-associated protein 6 1 20254200.0 4492800.0 6178600.0 9582800.0 True False 5816018.166328111 5834755.478574096 7838828.72783132 1.0 1.00322167361073 1.347799904273733 22.47160034484553 -6.908949182280008 0.9028817651118245 0.988972435348437 1.3913409462351292 0.9905178896680434 0.01589182118244462 0.10511806872611869 0.1425769594518637 0.012943447864578104 0.035473984772088726 1.2332491298872584e-07 6.908949182280008 0.4023685108866921 WLHNEDQMAVEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WLHNEDQMAVEK 12 0 P37837 P37837 TALDO1 Transaldolase 0 19085900.0 2810400.0 7295200.0 8980300.0 False True 3684461.615952317 6206784.596466876 8051104.701120321 1.0 1.6845838669057807 2.185150923071664 21.81302239332797 -7.264202817357252 0.1170524983853734 1.091740528334619e-15 3.737676046178223 0.999998343199014 0.0006252486156033671 0.10439261280155247 0.006221070810313096 0.07067010561516347 0.12173099612436858 5.442484271707378e-08 7.264202817357252 3.737676046178222 WLHNEDQMAVEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WLHNEDQMAVEK 12 0 P37837 P37837 TALDO1 Transaldolase 0 15632300.0 5568400.0 1353200.0 8710700.0 False True 5391634.189988063 1893539.8168447753 6429106.354601412 1.0 0.3511996085270332 1.1924225806231201 22.362291185615252 -6.70074400162248 1.8283047587052068 0.5974089250122953 1.1899465781027212 0.42104158189013285 0.27383046429152935 0.3939917319795281 2.5609651198929018 0.1194645956333803 0.3069394997286843 1.9918471033160366e-07 6.70074400162248 0.5925376530904259 WLHNEDQMAVEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WLHNEDQMAVEK 12 0 P37837 P37837 TALDO1 Transaldolase 0 19144000.0 2810400.0 8579800.0 7753800.0 False True 3849480.8282042895 8200716.066395527 5922512.134523649 1.0 2.1303433975591473 1.5385223095880152 21.87623245485086 -10.140203060484833 5.5415803465245475 0.9999856531164825 1.8344328535737147 0.7260708055092226 0.24160994742514824 4.282686045757508e-05 6.644595885108685e-06 0.23394184048866704 0.07797927522123588 7.240973190412541e-11 10.140203060484833 0.8344472004572322 WLHNEDQMAVEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WLHNEDQMAVEK 12 0 P37837 P37837 TALDO1 Transaldolase 0 7462980.0 5568400.0 1276400.0 618180.0 False True 4630371.32194653 1269523.779854437 747438.5798586224 1.0 0.27417321238089193 0.16142087273130654 22.14269646104953 -13.999999999999998 0.2621318973540845 6.3729807987734945 0.12104443390967978 0.9995667145750361 0.007734958700310809 14.51239078784247 0.16202534612190833 41.35740615185633 0.04874630308765369 1.0000000000000041e-14 13.999999999999998 -6.251936364863814 WLHNEDQMAVEK(ub)LSDGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WLHNEDQMAVEKLSDGIR 18 1 P37837 P37837 TALDO1 Transaldolase 1 23181700.0 5548700.0 8073700.0 9559300.0 True False 7274399.433687242 6869135.431036102 8570195.335280502 1.0 0.9442890088253347 1.178130980214328 22.794396714966254 -6.843839756273823 1.264358027580392 0.9703598331868903 1.1864296018462197 0.9308632686651728 0.026223130098637085 0.16436705074987734 0.5087277619920859 0.016251312285658293 0.037489370083669794 1.4327164380416754e-07 6.843839756273823 0.21606976865932936 WLHNEDQMAVEK(ub)LSDGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WLHNEDQMAVEKLSDGIR 18 1 P37837 P37837 TALDO1 Transaldolase 1 35506700.0 7983900.0 7908800.0 19614000.0 True False 7730455.464665904 11066825.08384716 14476504.992612787 1.0 1.4315877162000374 1.8726587403266846 22.88212198700042 -6.970853809807541 0.23690798008581024 0.8354249105608843 2.481530359897686 0.9999882971828348 0.0012187586261398998 0.07602660536615187 0.00803218905883492 0.010778067720086654 0.043240501780928954 1.069414800087487e-07 6.970853809807541 1.646105449336802 WLHNEDQMAVEK(ub)LSDGIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WLHNEDQMAVEKLSDGIR 18 1 P37837 P37837 TALDO1 Transaldolase 1 53864000.0 15277000.0 18547000.0 20040000.0 True False 23176325.89830255 15237142.941627596 16079085.21615598 1.0 0.6574442820871609 0.6937719674253295 24.466148540805083 -9.896799387153004 6.765251512351346 1.0000000111594267 0.6756081250376863 0.9906818211737595 0.014830715435835988 2.486399727904441e-09 4.1117554884132944e-10 0.014359778901779197 0.004786592824608295 1.2682375652053897e-10 9.896799387153004 -0.3243918861217404 WLHNEDQMAVEK(ub)LSDGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WLHNEDQMAVEKLSDGIR 18 1 P37837 P37837 TALDO1 Transaldolase 1 24371400.0 5548700.0 8952200.0 9870500.0 True False 7600204.337979342 8556662.20303342 7539291.189328561 1.0 1.12584633550897 0.991985327506737 22.857606776489146 -6.660130080750346 1.9727028860976854 1.0809997411827905 0.99254695581441 0.23600049237177279 0.05358139808959307 0.48416489128370566 3.6222442751364965 0.021944560250033614 0.059388068636297 2.1871064393457924e-07 6.660130080750346 -0.08845278536838053 WLHNEDQMAVEK(ub)LSDGIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WLHNEDQMAVEKLSDGIR 18 1 P37837 P37837 TALDO1 Transaldolase 1 26474800.0 7983900.0 11256000.0 7234900.0 True False 6638966.596740326 11195361.693858923 8747684.139601987 1.0 1.6863108935290845 1.317627376510227 22.662527262434697 -10.130509765290466 4.435172848448866 0.9999320082658514 1.5019691350392284 0.7119517496978738 0.1505144156219485 105087529.31025374 10.09922143561061 74991.652268778 0.05152508790470434 7.404406181511681e-11 10.130509765290466 0.502037126773377 WLHNEDQMAVEK(ub)LSDGIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WLHNEDQMAVEKLSDGIR 18 1 P37837 P37837 TALDO1 Transaldolase 1 51324000.0 15277000.0 14627000.0 21420000.0 True False 19776377.654690735 13812994.591833629 17521779.787760008 1.0 0.6984592847597316 0.885995407940849 24.237274862897532 -10.396218367453955 5.695194556793983 1.0000756712865795 0.7922273471252722 0.6207253357877669 0.0765613016889135 7.358881620349883e-05 7.801598161901989e-06 0.07415708650786926 0.02471005386709336 4.015888373356361e-11 10.396218367453955 -0.20784832416130727 WLITLNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WLITLNK 7 0 P06730;P06730-2;D6RBW1;P06730-3;H0Y8J7 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 59691000.0 19431000.0 20084000.0 20176000.0 False True 25474229.170071654 17087545.486818835 18088381.061858017 1.0 0.6707777249210783 0.7100658842744931 24.602535156457776 -10.307196945577907 8.551369825290129 1.0000003684302272 0.6904218047522058 0.9880648086051551 0.016039323891503417 1.1266341859911972e-07 9.119836611872776e-09 0.015530027091461448 0.005176669526351617 4.929502082517479e-11 10.307196945577907 -0.3095785636780214 WLITLNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WLITLNK 7 0 P06730;P06730-2;D6RBW1;P06730-3;H0Y8J7 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 36124400.0 18229000.0 5851400.0 12044000.0 False True 17650330.373050105 8187894.534647885 8889315.087744888 1.0 0.46389468987786187 0.5036344872795007 24.073191851849653 -9.9953722441394 6.405017513018808 1.0000001897530606 0.4837645901438823 0.9955752258019677 0.016223704352634302 4.3956326373108204e-08 6.90712912915115e-09 0.01570853992759335 0.005236178064290326 1.0107127769056071e-10 9.9953722441394 -0.5162355996091783 WLITLNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WLITLNK 7 0 P06730;P06730-2;D6RBW1;P06730-3;H0Y8J7 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 33977700.0 9053700.0 12612000.0 12312000.0 False True 13735124.814129863 10361290.06199423 9878527.803458706 1.0 0.7543644635347736 0.7192164568680348 23.711366684775143 -13.999999999355778 0.2738613505136833 2.935830791222444 0.707979290708311 0.9995916864330961 0.002523922437323107 15.07601884530535 0.1656991157854303 16.28615935384484 0.014321465470439202 1.000000001483377e-14 13.999999999355778 -2.227851500514133 WLITLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WLITLNK 7 0 P06730;P06730-2;D6RBW1;P06730-3;H0Y8J7 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 68410000.0 19431000.0 26508000.0 22471000.0 False True 26615165.80303069 25336788.909766283 17163812.604771994 1.0 0.9519681033465951 0.6448884343533767 24.665745217980668 -6.934506580043262 0.7088235656769049 1.0039812145914777 0.5739441071274424 0.9973522011000353 0.008094503640919244 0.09036445389085085 0.06670521691186171 0.007583251553688781 0.027129990255194948 1.162768933630426e-07 6.934506580043262 -0.43003710746403534 WLITLNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WLITLNK 7 0 P06730;P06730-2;D6RBW1;P06730-3;H0Y8J7 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 36097400.0 18229000.0 10508000.0 7360400.0 False True 15158221.181625444 10451391.31832531 8899425.609355547 1.0 0.68948666160079 0.587102239947738 23.85359712728393 -13.999999997533266 0.1550774831089632 2.5144134975324954 0.48077931592137924 0.9995501859247233 0.0037233747506197103 11.980458148065646 0.12426125703385785 5.460699751316787 0.09634051306313224 1.0000000056798659e-14 13.999999997533266 -2.033634181611116 WLITLNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WLITLNK 7 0 P06730;P06730-2;D6RBW1;P06730-3;H0Y8J7 P06730 EIF4E Eukaryotic translation initiation factor 4E 0 75665700.0 9053700.0 39585000.0 27027000.0 False True 11720193.125107914 37382059.9519884 22108363.32043837 1.0 3.189543000951548 1.8863480391868377 23.482493006867593 -10.068428618036092 4.870324757392481 0.9999618331610451 2.537945520079411 0.6499772348243196 0.5320271153477167 184589610.88470224 6.815984490449619 92441.07597875684 0.18212703266510627 8.542232386141306e-11 10.068428618036092 1.537983686918366 WLK(ub)EDKLECSEELGDLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WLKEDKLECSEELGDLVK 18 2 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 1 20986800.0 9379200.0 5401800.0 6205800.0 True False 12296222.028302 4595872.496051479 5563683.34623704 1.0 0.3737629725189769 0.45247095680536725 23.55171178479514 -10.595205772884825 6.479061532930248 1.0013991518471153 0.41311696466329517 0.9866900478541005 0.03213240003077546 0.0006506782953062917 4.0652575471677286e-05 0.031172610092364713 0.010370687516072341 2.5397690535196133e-11 10.595205772884825 -0.5882821871838201 WLK(ub)EDKLECSEELGDLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WLKEDKLECSEELGDLVK 18 2 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 1 44738000.0 18833000.0 14287000.0 11618000.0 True False 28571037.87672532 11737373.225159498 9321697.207649695 1.0 0.4108136804760969 0.3262638637024587 24.76805010904053 -13.999999999999998 0.2734496754771313 5.63296974357699 0.29912379658178057 0.9995907916693142 0.00606195595422356 15.055043128064442 0.16556959416226685 38.85491061365389 0.034520355642348594 1.0000000000000041e-14 13.999999999999998 -5.3338459469952095 WLK(ub)EDKLECSEELGDLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WLKEDKLECSEELGDLVK 18 2 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 1 19997900.0 9379200.0 4709400.0 5909300.0 True False 12846943.703349574 4501323.1360967755 4513645.04585373 1.0 0.35038085633730526 0.351339987944128 23.61492184631803 -10.119994534393468 7.607284257839305 1.0000001311856594 0.350860422140717 0.9999983622968339 0.0003915638388152727 8.711481102864984e-10 1.0062784087272855e-10 0.0003791301329430781 0.00012637668555904875 7.585871218063386e-11 10.119994534393468 -0.6491397090449424 WLK(ub)EDKLECSEELGDLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WLKEDKLECSEELGDLVK 18 2 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 1 10456800.0 3217500.0 2845700.0 4393600.0 True False 2675493.809417953 2830369.6492727776 5312281.446288862 1.0 1.057886824222747 1.9855330734046948 21.35137376014633 -6.919638722267877 0.8274040017402144 0.979264545280783 2.13388734558891 0.9940799608171261 0.03474379659789118 0.09838469794791714 0.10671980670973112 0.029878238448135638 0.08919246388347395 1.2032649817095165e-07 6.919638722267877 1.1546228003081271 WLK(ub)EDKLECSEELGDLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WLKEDKLECSEELGDLVK 18 2 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 1 37995500.0 18833000.0 7710500.0 11452000.0 True False 24379689.753930174 7281403.896925774 9367853.507442942 1.0 0.29866679889771613 0.3842482657488609 24.53917643113298 -10.655296338936784 6.680840574503095 1.003278487868683 0.3414575323300606 0.9874920322205636 0.03493848753736961 0.0017102585595807284 8.824220801220354e-05 0.03391102158132558 0.011276348364492317 2.2115851292139803e-11 10.655296338936784 -0.6618209555386223 WLKEDK(ub)LECSEELGDLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WLKEDKLECSEELGDLVK 18 2 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 1 19166600.0 8355800.0 5222900.0 5587900.0 True False 10954534.717682311 4443663.678704745 5009717.710921708 1.0 0.4056460446039744 0.4573190774442706 23.385024872889495 -10.38424054843686 9.131031322966658 1.0000013558915186 0.43148256245051697 0.993842291977078 0.021095427320133996 5.822799573058251e-07 3.9266447228964556e-08 0.02042560835471294 0.006808519891000672 4.128187852465119e-11 10.38424054843686 -0.5685187934410016 WLKEDK(ub)LECSEELGDLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WLKEDKLECSEELGDLVK 18 2 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 1 15876200.0 8355800.0 2647000.0 4873400.0 True False 11445165.067004483 2530046.7875415455 3722403.2908235397 1.0 0.2210581300251818 0.3252380607034614 23.448234934412387 -10.740654640894492 7.033615119820725 1.0108970888947082 0.2731480953643216 0.9848261046032635 0.0425312786000514 0.007153673515243629 0.0002637718331098514 0.040534403408037635 0.013726911142575583 1.8169599690228582e-11 10.740654640894492 -0.7377489935303866 WLKEDK(ub)LECSEELGDLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WLKEDKLECSEELGDLVK 18 2 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 1 8581200.0 1661700.0 2534600.0 4384900.0 True False 1381777.1757917053 2520945.606721288 5301762.316513106 1.0 1.8244226716777856 3.836915538480653 20.39809355603538 -6.955971119072163 0.4889250824674927 0.955526016131862 4.790994618033808 0.999590340631019 0.02411680390685422 0.08117308367304747 0.026698212966445246 0.028908856865743685 0.16598460135730314 1.1066973777848568e-07 6.955971119072163 3.8354686019019457 WLLFFHFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WLLFFHFGK 9 0 Q8IXB1;Q8IXB1-2 Q8IXB1 DNAJC10 DnaJ homolog subfamily C member 10 0 31478500.0 5161600.0 11774200.0 14542700.0 False True 7830524.563505823 9673002.017755514 11668328.970708143 1.0 1.2352942563818217 1.4901082138339004 22.900677525604163 -6.970106859315885 0.2556216532315493 0.9245260352526031 1.808393537036792 0.9999832032673961 0.0008202245906075152 0.0762680477807201 0.00890602906093666 0.005473570298240307 0.02420347915572136 1.0712556874872053e-07 6.970106859315885 0.8838675017841889 WLLFFHFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WLLFFHFGK 9 0 Q8IXB1;Q8IXB1-2 Q8IXB1 DNAJC10 DnaJ homolog subfamily C member 10 0 24594000.0 5161600.0 7754800.0 11677600.0 False True 6681792.950347038 7323238.562982942 9552396.622294428 1.0 1.0959990256211978 1.429615777274017 22.671803847696612 -6.9481079453749865 0.5792521166284051 0.9960008740078801 1.5460936988909921 0.9990442458492282 0.0056919689221272265 0.08425468856945263 0.03917751432198032 0.005968534364516119 0.027863202915457002 1.1269173222181349e-07 6.9481079453749865 0.5500928248831121 WLLLTGISAQQNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WLLLTGISAQQNR 13 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 17437600.0 4944700.0 6186100.0 6306800.0 False True 6482549.584542923 5263157.993228934 5654232.835097452 1.0 0.8118962955221318 0.8722236153163379 22.628129905512747 -10.1435704753262 6.948678960752373 1.0000001767821605 0.8420599554192348 0.9013702245280851 0.024628525174251466 6.746997691846692e-08 8.28433961623914e-09 0.023846493610717962 0.007948822320127155 7.185045532803264e-11 10.1435704753262 -0.15794022136292563 WLLLTGISAQQNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WLLLTGISAQQNR 13 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 10937200.0 4814400.0 2295400.0 3827400.0 False True 4661569.5072693275 3211965.1903528697 2824889.120461206 1.0 0.6890308479459716 0.6059952803569758 22.152384348049967 -13.999999999999998 0.185333705760656 2.6409970324066987 0.5435447197767751 0.9994926645698347 0.003819781782972146 12.278438659118448 0.13650881812472035 7.265727958387893 0.059297417862223686 1.0000000000000041e-14 13.999999999999998 -2.0974523126299234 WLLLTGISAQQNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WLLLTGISAQQNR 13 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 49256000.0 11095000.0 17027000.0 21134000.0 False True 16831926.15314963 13988398.817441788 16956855.636638746 1.0 0.8310634617906902 1.0074221739302092 24.004696944420257 -13.11997661755704 20.22079566086945 7.128398707727118 0.9273162449631173 0.0 0.08359522787492238 0.0 0.0 0.0 0.024161969397930118 7.586184179943103e-14 13.11997661755704 -6.201082462764 WLLLTGISAQQNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WLLLTGISAQQNR 13 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 26401900.0 4944700.0 7280200.0 14177000.0 False True 6772889.215493082 6958536.691598017 10828684.584480107 1.0 1.0274103813303581 1.5988279506638516 22.69133996703564 -6.9168949537925375 0.8474270105852046 0.9859268703847849 1.6847027126457097 0.993274279680082 0.022639520608554977 0.10003336886927769 0.11533228827336636 0.019192113356479686 0.0558892578739732 1.2108909858175045e-07 6.9168949537925375 0.6987758422609248 WLLLTGISAQQNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WLLLTGISAQQNR 13 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 12510500.0 4814400.0 4009100.0 3687000.0 False True 4003386.914082926 3987502.18255596 4457934.653238121 1.0 0.9960321767873378 1.1135407965580866 21.932789623484243 -6.899082575573373 0.9670231982105789 0.9949906768370458 1.1256491773721067 0.986105081745684 0.006422268853076183 0.11208467471436905 0.18124144310329235 0.004989345492466968 0.012923064056909135 1.2615876369374632e-07 6.899082575573373 0.1306585005350609 WLLLTGISAQQNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WLLLTGISAQQNR 13 0 A0A087WVQ6;Q00610-2;Q00610 A0A087WVQ6 CLTC Clathrin heavy chain;Clathrin heavy chain 1 0 46051000.0 11095000.0 20203000.0 14753000.0 False True 14362696.215146547 19078685.290135697 12068105.37856319 1.0 1.3283498449278475 0.8402395481870919 23.775823266512706 -6.725472954688975 1.7397041723968927 1.1985888144893937 0.8407599711992916 0.5381700842287462 0.13808643455059946 0.34479161962165633 2.0421912998007565 0.06295550788539891 0.1570287978069681 1.88159887750306e-07 6.725472954688975 -0.3578288432901021 WLLYHELVLTTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WLLYHELVLTTK 12 0 O60231;Q5SQH5;A0A140T8Y5 O60231 DHX16 Putative pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16 0 6493200.0 2255600.0 2087500.0 2150100.0 False True 2919918.6645231675 1971328.7899400203 1758803.8618890226 1.0 0.6751314048201219 0.6023468678283342 21.47749675215434 -13.999999999764858 0.21019917329124632 2.880370295676867 0.5595594980214935 0.9994901235377639 0.00390354152732877 12.751372275715058 0.14531606424621119 9.903436005269926 0.043053933224348896 1.0000000005414337e-14 13.999999999764858 -2.3208107976553736 WLMINIQNVQDFACQCLNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WLMINIQNVQDFACQCLNR 19 0 O94888;C9JAT7 O94888 UBXN7 UBX domain-containing protein 7 0 41011000.0 13972000.0 13340000.0 13699000.0 False True 21196545.49002313 10959372.774104284 10991386.645515012 1.0 0.5170357961990875 0.5185461305800269 24.337325824730748 -10.073755763169533 5.528993845399715 1.0000036478473435 0.5177909633893659 0.9999926417985724 0.000616591429720874 2.772546762989509e-08 4.645264912343668e-09 0.0005970166023394839 0.00019900402812918298 8.438091624481066e-11 10.073755763169533 -0.4822126844579776 WLPAGDALLQMITIHLPSPVTAQK ddPTM_RPMI8226_Bortezomib_2h_R1 2 WLPAGDALLQMITIHLPSPVTAQK 24 0 P13639 P13639 EEF2 Elongation factor 2 0 6247080800.0 3830000800.0 548610000.0 1868470000.0 False True 3708419521.040441 767672833.963355 1379061654.101518 1.0 0.20700808784114458 0.37187315142667726 31.788157314424588 -10.263367712599445 8.171805469623408 1.000000679179676 0.2894406198191638 0.9611914273518929 0.06730588036600979 8.328671457314993e-07 7.498440097262808e-08 0.06516870057879239 0.02172287947994872 5.4529596918058175e-11 10.263367712599445 -0.7105600593605123 WLPAGDALLQMITIHLPSPVTAQK ddPTM_RPMI8226_Bortezomib_8h_R1 2 WLPAGDALLQMITIHLPSPVTAQK 24 0 P13639 P13639 EEF2 Elongation factor 2 0 44222578030.0 17475914000.0 13394338500.0 13352325530.0 False True 26512239198.44917 11004014144.230585 10713232536.463295 1.0 0.41505412130086183 0.4040862960036195 34.62593947287256 WLPAGDALLQMITIHLPSPVTAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 WLPAGDALLQMITIHLPSPVTAQK 24 0 P13639 P13639 EEF2 Elongation factor 2 0 7414180800.0 3830000800.0 1504560000.0 2079620000.0 False True 3184815363.004136 1496454636.6482234 2514458926.9235344 1.0 0.4698717087437888 0.7895148196445914 31.568562589858864 -10.346080661418467 6.0221113754388815 1.0000427156013127 0.6296932641941954 0.6415125825151924 0.13049375358380474 7.484735255886129e-05 8.127425523022843e-06 0.1263645624789739 0.042116677867847334 4.507329822293254e-11 10.346080661418467 -0.3703494514071174 WLPAGDALLQMITIHLPSPVTAQK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 WLPAGDALLQMITIHLPSPVTAQK 24 0 P13639 P13639 EEF2 Elongation factor 2 0 37765811080.0 17475914000.0 12230888690.0 8059008390.0 False True 22622915174.765892 11550228982.58625 6592351555.429074 1.0 0.5105544043885925 0.29140150614993826 34.397065794965016 -11.335726271227552 0.14725958108243262 2.119863498062042 3.969513780278353e-26 0.999650866720718 0.0055348304881588884 3.878545733936385 0.09074891460396378 1.6302929620916269 0.21164970103328615 4.616084272003348e-12 11.335726271227552 -2.119863498062042 WLPLGLGLNHLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WLPLGLGLNHLGK 13 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 67869000.0 18819000.0 23096000.0 25954000.0 False True 24671891.24345526 19650166.827502858 23268529.04834771 1.0 0.796459689028318 0.9431189858426512 24.556364975024852 -10.455100076953237 5.00061274241857 1.0002453652470127 0.8697893374354765 0.5124386648993661 0.059873407205111945 0.00016409153197264565 1.788045437543959e-05 0.05808096054624909 0.01932405908217045 3.506710575105851e-11 10.455100076953237 -0.1304560278115362 WLPLGLGLNHLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WLPLGLGLNHLGK 13 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 107983000.0 45173000.0 26249000.0 36561000.0 False True 43739007.84145011 36730362.58672671 26984577.293510526 1.0 0.8397621345200811 0.6169453452471337 25.382417159438557 -6.966485834223788 0.3315625034530489 1.0266563373359294 0.4227398518934979 0.9999405775719938 0.0012108174215463882 0.07746029917033162 0.013101401590654838 0.0032333983618890246 0.01941029577299712 1.0802248549791012e-07 6.966485834223788 -0.6039164854424315 WLPLGLGLNHLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WLPLGLGLNHLGK 13 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 83878000.0 21994000.0 34537000.0 27347000.0 False True 33366505.97677993 28373602.511187386 21941853.4633841 1.0 0.8503618128590643 0.6576011728244379 24.991897284687685 -6.96766397736339 0.3089429921790828 1.0300695068665267 0.47177564461773225 0.9999579926927963 0.0009083544685349241 0.07706831869268897 0.011730132107029924 0.0030645380391341554 0.01713107118687085 1.0772984193561832e-07 6.96766397736339 -0.5582938622487944 WLPLGLGLNHLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WLPLGLGLNHLGK 13 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 142530000.0 18819000.0 40357000.0 83354000.0 False True 25776892.864352595 38573894.29724757 63667501.92951642 1.0 1.4964524429006032 2.4699447782383244 24.619575036547744 -6.960429169536389 0.4293423780575196 0.9610606028635982 3.0426279748397285 0.9997857870946967 0.008935947597843288 0.07954816142676867 0.02056746269186961 0.012686186800230818 0.08084239971652274 1.0953951922730275e-07 6.960429169536389 2.0815673719761305 WLPLGLGLNHLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WLPLGLGLNHLGK 13 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 77117000.0 45173000.0 15380000.0 16564000.0 False True 37563351.00321288 15297144.887309019 20027455.816717193 1.0 0.40723589559410234 0.5331647811454362 25.162822434872833 -9.821479476087976 6.503546691979565 1.0000000114696004 0.4702003383702078 0.959349536155631 0.05141025224665981 8.53408629974226e-09 1.5397102473644304e-09 0.04977776343551748 0.016592587564590856 1.5084138935611675e-10 9.821479476087976 -0.5297996730993926 WLPLGLGLNHLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WLPLGLGLNHLGK 13 0 Q13200;Q13200-3;Q13200-2;H7C1H2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 0 143996000.0 21994000.0 73002000.0 49000000.0 False True 28471666.566555515 68939374.52608462 40082502.78245755 1.0 2.42133260323668 1.407803181761787 24.763023606780134 -10.19687867950188 5.844293167912965 0.9999814857185342 1.9145678924992462 0.5205378108714491 0.41377165365200724 9.982601320761285e-05 1.371815570703731e-05 0.4006407688456171 0.13354422697723614 6.355084368289656e-11 10.19687867950188 0.914586406780712 WLPTHVQVTVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WLPTHVQVTVLR 12 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 0 16977400.0 7073900.0 2482700.0 7420800.0 False True 6849342.9165571015 3474055.0571094626 5477069.860771942 1.0 0.5072099761148673 0.7996489484461455 22.70753416082883 -10.287879887540212 5.830667056721093 1.0000244149792785 0.6534294622805062 0.6518867070662573 0.11938771051925977 3.789361031083502e-05 4.628187441467269e-06 0.11560478381883339 0.03853221788190949 5.1537116064174727e-11 10.287879887540212 -0.3465949526987723 WLPTHVQVTVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WLPTHVQVTVLR 12 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 0 58198000.0 21226000.0 19208000.0 17764000.0 False True 32201393.82845915 15780182.327211017 14252937.613762194 1.0 0.490046561688417 0.4426186546361743 24.940619800560288 -13.999999999999998 0.33602138376294655 6.757060577719255 0.43479995744015515 0.9997271995938459 0.004167436632862641 19.344836373445737 0.18570527559651218 78.94967815302047 0.014865085834660846 1.0000000000000041e-14 13.999999999999998 -6.322260620279099 WLPTHVQVTVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WLPTHVQVTVLR 12 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 0 14917400.0 1963700.0 4521000.0 8432700.0 False True 2689732.9569971384 4321247.271052265 6441069.936908054 1.0 1.60657111324411 2.394687517268989 21.35903151506513 -6.967534166590386 0.3115069039341694 0.8807245913493625 3.145640740552658 0.9999562603265741 0.003776257031072105 0.07711121361783599 0.011879940203210438 0.012385603008985616 0.0698682914736376 1.0776204723601579e-07 6.967534166590386 2.2649161492032954 WLPTHVQVTVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WLPTHVQVTVLR 12 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 0 13394800.0 7073900.0 3189700.0 3131200.0 False True 5882261.276904956 3172516.452994124 3785919.442966968 1.0 0.5393362014452022 0.6436163347302023 22.487939436263105 -9.76641939958733 6.1043307549759085 1.0000000120512833 0.591476268086951 0.9534082778119721 0.042572186145695044 6.949581038320738e-09 1.4087103040616008e-09 0.041220342601499295 0.013740113995756515 1.7123029323334279e-10 9.76641939958733 -0.40852374396433233 WLPTHVQVTVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WLPTHVQVTVLR 12 0 A0A1B0GTL5;Q9BXF6 A0A1B0GTL5 RAB11FIP5 Rab11 family-interacting protein 5 0 45154000.0 21226000.0 23928000.0 0.0 False True 27477475.42701224 22596385.76559756 0.0 1.0 0.8223603302137344 0.0 24.711746122652738 -7.216936763102555 0.8785750883749185 0.9901028412836816 8.4469870211213e-16 0.9891781319715724 0.0453160949723123 0.09468357382473143 0.13954105740937486 0.03825702642899948 0.06721528343481173 6.06824681888947e-08 7.216936763102555 -0.9901028412836808 down WLSTSIPEAQWHSSLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WLSTSIPEAQWHSSLAR 17 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 25971000.0 8415800.0 10976000.0 6579200.0 False True 11033195.298723126 9338423.584112894 5898447.496142757 1.0 0.8463933911505792 0.534609180427123 23.395347331299913 -6.959754999061525 0.43887422030021417 1.0112798365750373 0.35758944040091956 0.9997610005730373 0.0029932597162657523 0.07978877621356177 0.021455681395538564 0.004105013975174025 0.02583884474465496 1.097096932937435e-07 6.959754999061525 -0.6536903961741177 WLSTSIPEAQWHSSLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WLSTSIPEAQWHSSLAR 17 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 26896300.0 8415800.0 9407400.0 9073100.0 False True 11527348.688443502 8991749.961888298 6930220.64636005 1.0 0.7800362602809773 0.6011981448351428 23.458557392822804 -6.973483115264818 0.15367533245395978 1.197507120485824 0.17900872983483795 0.9999983794963538 0.00020754245616864985 0.07518785645007567 0.004713983243268026 0.008800851173742404 0.0219838194235774 1.0629599088011781e-07 6.973483115264818 -1.0184983906509861 WLSYTLGVHVNQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WLSYTLGVHVNQAK 14 0 Q15054 Q15054 POLD3 DNA polymerase delta subunit 3 0 10141900.0 4626100.0 2115500.0 3400300.0 False True 4479246.987699118 2960230.1821867637 2509659.4231865634 1.0 0.6608767478810904 0.5602860101437976 22.094824788566335 -13.999999999999998 0.17033794507815003 2.711726303586067 0.47187194967155005 0.999513036733126 0.0041510856324373435 12.094806691102121 0.13070179959768496 6.840978667798766 0.0817585744793845 1.0000000000000041e-14 13.999999999999998 -2.239854353914517 WLSYTLGVHVNQAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WLSYTLGVHVNQAK 14 0 Q15054 Q15054 POLD3 DNA polymerase delta subunit 3 0 78351000.0 26593000.0 20484000.0 31274000.0 False True 40343525.20871639 16828470.157777525 25092680.192118887 1.0 0.41712939240474856 0.6219753990833083 25.26583381605851 -10.071135422086103 5.07221331328211 1.0000093378470003 0.5195523957422702 0.8800180817133741 0.08362803204099936 8.830896613544688e-06 1.6171792216060354e-06 0.0809740662480517 0.026990831280028806 8.489157241156695e-11 10.071135422086103 -0.4804569421047301 WLSYTLGVHVNQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WLSYTLGVHVNQAK 14 0 Q15054 Q15054 POLD3 DNA polymerase delta subunit 3 0 9277400.0 4626100.0 2538000.0 2113300.0 False True 3846807.120978528 2524327.290246446 2555181.259204807 1.0 0.656213636623487 0.6642343062302628 21.87523006400061 -10.270354536985023 5.5303031068888036 1.0000313351779098 0.660223971426864 0.9995822495454282 0.0032744246553802693 1.2651935788668615e-06 1.6692820193238887e-07 0.003170739887219641 0.001056816013219297 5.3659356851492377e-11 10.270354536985023 -0.3398073637510458 WLSYTLGVHVNQAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WLSYTLGVHVNQAK 14 0 Q15054 Q15054 POLD3 DNA polymerase delta subunit 3 0 74066000.0 26593000.0 24892000.0 22581000.0 False True 34425162.72639859 23506738.318173412 18471489.700626004 1.0 0.682835939077421 0.5365694229953873 25.03696013815096 -13.999999999999991 0.10381441792045668 2.5503216207982478 0.24267178844159373 0.9997744884370815 0.00290481992599674 12.052533545588501 0.09670389181538011 3.966634143145701 0.26160668332621456 1.0000000000000205e-14 13.999999999999991 -2.307649832356654 WLTLEVCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WLTLEVCR 8 0 Q9NR56;C9JP00;A0A0A0MQX8;Q9NR56-6;Q9NR56-7;Q9NR56-4;H7C4T5;Q9NR56-3;Q9NR56-2;Q9NR56-5;Q5VZF2-3;Q5VZF2-2;O95205;Q5VZF2;B1AKI6;Q9NUK0-2;Q9NUK0 Q9NR56;B1AKI6 MBNL1;MBNL2;MBLL;MBNL3 Muscleblind-like protein 1;Muscleblind-like protein 2;Muscleblind-like protein 3 0 41989000.0 11935000.0 16711000.0 13343000.0 False True 18106267.565375473 13728791.486361057 10705750.201555347 1.0 0.7582342101590588 0.5912731689676287 24.109985843305022 -7.752923914840277 0.09936980262025877 1.4756308832499985 2.448416515605522e-11 0.9999944151676069 0.0003964857987461844 0.13475027021336697 0.012450002396824783 0.07803539216491354 0.09915756937032567 1.7663472444670273e-08 7.752923914840277 -1.4756308832255143 WLTLEVCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WLTLEVCR 8 0 Q9NR56;C9JP00;A0A0A0MQX8;Q9NR56-6;Q9NR56-7;Q9NR56-4;H7C4T5;Q9NR56-3;Q9NR56-2;Q9NR56-5;Q5VZF2-3;Q5VZF2-2;O95205;Q5VZF2;B1AKI6;Q9NUK0-2;Q9NUK0 Q9NR56;B1AKI6 MBNL1;MBNL2;MBLL;MBNL3 Muscleblind-like protein 1;Muscleblind-like protein 2;Muscleblind-like protein 3 0 3132790.0 840140.0 782650.0 1510000.0 False True 1150762.461929815 748069.9351225507 1153369.0994261797 1.0 0.6500645961878583 1.0022651394902067 20.13415863532025 -10.993020188077718 9.958100652155476 1.1481262002625483 0.8261648678390321 0.2451766570672096 0.1437852697036275 0.07067819664063502 4.953961318423812e-05 0.020809484112914854 0.046406496249340914 1.0162014538851413e-11 10.993020188077718 -0.3219613324235162 WLTLEVCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WLTLEVCR 8 0 Q9NR56;C9JP00;A0A0A0MQX8;Q9NR56-6;Q9NR56-7;Q9NR56-4;H7C4T5;Q9NR56-3;Q9NR56-2;Q9NR56-5;Q5VZF2-3;Q5VZF2-2;O95205;Q5VZF2;B1AKI6;Q9NUK0-2;Q9NUK0 Q9NR56;B1AKI6 MBNL1;MBNL2;MBLL;MBNL3 Muscleblind-like protein 1;Muscleblind-like protein 2;Muscleblind-like protein 3 0 44809000.0 11935000.0 17486000.0 15388000.0 False True 15450092.774021998 16512888.728570664 12587541.894213414 1.0 1.0687889691080474 0.8147227384536022 23.88111216539747 -6.834613943846034 1.3073108463879588 1.0366547068181824 0.8072258826229122 0.914763262010727 0.03132502191736567 0.17518862142636477 0.5839335008872084 0.0188045547732012 0.04327610275990631 1.4634775213093362e-07 6.834613943846034 -0.22942882419527022 WMIQYNNLNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WMIQYNNLNLK 11 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 31790000.0 13916000.0 14685000.0 3189000.0 False True 18244010.762735702 12494055.241681674 2859032.8710480365 1.0 0.6848305125538187 0.1567107643286285 24.12091959061285 -7.3306806374698406 0.49945973196371907 1.0118176491208941 1.3215502755241731e-24 0.9983541306303808 0.014114512798206837 0.10348113108261917 0.05109464121512004 0.015669379323541347 0.05832524516813459 4.670026688815318e-08 7.3306806374698406 -1.0118176491208941 down WMIQYNNLNLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WMIQYNNLNLK 11 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 42184900.0 24274000.0 7091900.0 10819000.0 False True 23503435.156915843 9923732.653769922 7985179.3369571585 1.0 0.42222477640039274 0.3397452025053254 24.486368294264135 -13.999999999999998 0.2741978754671047 5.561716827647696 0.31346206234502133 0.9995924219674642 0.00593024187423984 15.093113874747983 0.1658037132324953 38.47622445187083 0.03355179059923431 1.0000000000000041e-14 13.999999999999998 -5.248254765302675 WMIQYNNLNLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WMIQYNNLNLK 11 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 39370200.0 9728200.0 14168000.0 15474000.0 False True 14758390.626685023 11639609.70491076 12415557.117504863 1.0 0.7886774377597029 0.8412541334321357 23.815032071145644 -9.956826327485942 5.054423744625421 1.0000008413321835 0.8149657855952808 0.942903307689961 0.021464346136393142 29458482.929518398 9.811461388805087 338.63326214097873 0.007347816599121146 1.104520224532952e-10 9.956826327485942 -0.1850350557369027 WMIQYNNLNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WMIQYNNLNLK 11 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 51002000.0 13916000.0 15489000.0 21597000.0 False True 19061121.26575963 14804644.76472648 16496233.404176956 1.0 0.7766932783393361 0.8654387732063749 24.18412965213574 -10.386470027769436 6.012909590919094 1.0000366092800153 0.8210660257961114 0.8442465776164165 0.036230196565838424 1.7784379263648777e-05 1.814628542098626e-06 0.03508690518232953 0.011693245660776059 4.107049831308406e-11 10.386470027769436 -0.17897058348390382 WMIQYNNLNLK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 WMIQYNNLNLK 11 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 71280400.0 12819600.0 34901200.0 23559600.0 False True 16595224.91209488 32958917.539379507 19271994.541909937 1.0 1.9860482586987112 1.1612975807193902 23.984264846346345 -10.148504894796387 4.300293395060082 0.999905400390777 1.573672918895093 0.3921314873822209 0.3367030549369312 48492033.86772347 38146423.50323064 50676.862006593205 0.11526240997031602 7.10387163407751e-11 10.148504894796387 0.5737675185043161 WNGFGGK(ub)VQEGETIEDGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WNGFGGKVQEGETIEDGAR 19 1 P36639-4;P36639-3;P36639-2;P36639 P36639-4 NUDT1 7,8-dihydro-8-oxoguanine triphosphatase 1 5719700.0 1212800.0 1511500.0 2995400.0 True False 1174300.3278531558 2115049.832368371 2210814.8799261902 1.0 1.8011149126008372 1.8826656413934415 20.16336999488772 -11.127787993317929 0.40479437121720585 2.695115404523843e-13 1.888274805336648 0.9995786018927004 0.008175572932674704 3.0661738159277205 0.19971424697024467 2.8221882046073787 0.02055296566290421 7.450956135682084e-12 11.127787993317929 1.8882748053363785 WNGFGGK(ub)VQEGETIEDGAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WNGFGGKVQEGETIEDGAR 19 1 P36639-4;P36639-3;P36639-2;P36639 P36639-4 NUDT1 7,8-dihydro-8-oxoguanine triphosphatase 1 37473700.0 2551200.0 6191500.0 28731000.0 True False 3870356.91770305 5086578.450589698 23052305.25675534 1.0 1.3142401485825863 5.956118711252151 21.88403518470078 -6.920612550995986 0.820163096147471 0.8998247840716852 6.715332444234045 0.9943495575837581 0.1703267143096782 0.09781273226352286 0.1037539287834728 0.14723192644941419 0.44365083793504007 1.2005698951065662e-07 6.920612550995986 5.81550766016236 up WNGFGGK(ub)VQEGETIEDGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WNGFGGKVQEGETIEDGAR 19 1 P36639-4;P36639-3;P36639-2;P36639 P36639-4 NUDT1 7,8-dihydro-8-oxoguanine triphosphatase 1 7119600.0 1212800.0 2732500.0 3174300.0 True False 1008496.9361498352 2717779.480141213 3838031.453695085 1.0 2.6948812462603504 3.805694708749078 19.943775270321996 -8.289812325326578 0.2193924163155054 3.625167141415521e-16 4.971196614079261 0.9996493788769714 0.021602206465191957 0.0973869792372739 0.05049708854134179 0.45109488767249717 0.45959672103656896 5.130830582160759e-09 8.289812325326578 4.971196614079261 WNGFGGK(ub)VQEGETIEDGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WNGFGGKVQEGETIEDGAR 19 1 P36639-4;P36639-3;P36639-2;P36639 P36639-4 NUDT1 7,8-dihydro-8-oxoguanine triphosphatase 1 44340800.0 2551200.0 7250600.0 34539000.0 True False 3302578.6916702907 6847097.736210355 28253256.400067393 1.0 2.073258013042957 8.55490785770746 21.65516150679323 -6.935696989019347 0.6984460052437814 0.9190860495846799 10.101695912724853 0.9975442269116552 0.16538420968684814 0.08978570910404139 0.06396668688794109 0.15615516388248107 0.5692345521182152 1.159586127154254e-07 6.935696989019347 9.182609863140174 WNHVWVGTETGILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WNHVWVGTETGILK 14 0 Q6RFH5;Q6RFH5-2;F5GYL6;F5H0Q8 Q6RFH5 WDR74 WD repeat-containing protein 74 0 16577000.0 4448100.0 6044400.0 6084500.0 False True 5831502.17546168 5142599.080886664 5454934.306645284 1.0 0.8818652426344202 0.9354252373597747 22.475436134042543 -10.135613930645285 4.407931763419731 1.000013108878044 0.9086452399940577 0.7950400559419397 0.021865776306436678 3.039768921162025e-06 5.960828978005565e-07 0.021174724414268795 0.007057148953984632 7.317893240605329e-11 10.135613930645285 -0.09136786888398629 WNHVWVGTETGILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WNHVWVGTETGILK 14 0 Q6RFH5;Q6RFH5-2;F5GYL6;F5H0Q8 Q6RFH5 WDR74 WD repeat-containing protein 74 0 20449500.0 4448100.0 5395400.0 10606000.0 False True 6092682.775382687 5157013.387798136 8101081.237426545 1.0 0.84642735850862 1.3296410688176208 22.538646195565434 -6.821221113235817 1.366436514077389 0.9173206122259993 1.3404799771960234 0.8871754803463702 0.0677124718938983 0.19191745362965 0.7037576298827396 0.03893555771422377 0.08971875177712435 1.5093115196585365e-07 6.821221113235817 0.42315936497002415 WNLAAVTPHDFIEHILR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WNLAAVTPHDFIEHILR 17 0 P30279;A0A3B3IT44;H0YGD4 P30279 CCND2 G1/S-specific cyclin-D2 0 60594900.0 20312400.0 14010300.0 26272200.0 False True 19667593.980445623 19604685.852749296 19390722.670894343 1.0 0.9968014324599708 0.9859224615971554 24.22931714166575 -6.948628436456 0.5740166220715716 1.0001331620209077 0.9820584427941417 0.9990859335857949 0.00018208073626447334 0.08404724282916458 0.038326507174154124 0.0001920363592873406 0.0009072790548051047 1.1255675489719922e-07 6.948628436456 -0.018074719226766067 WNLAAVTPHDFIEHILR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WNLAAVTPHDFIEHILR 17 0 P30279;A0A3B3IT44;H0YGD4 P30279 CCND2 G1/S-specific cyclin-D2 0 151304800.0 40987000.0 39464800.0 70853000.0 False True 62180275.551072046 32421998.100110248 56848873.494026944 1.0 0.5214193377686192 0.9142589509326614 25.88995367418875 -9.994886065197411 7.024336314419024 1.0000000245605707 0.7178391443506404 0.4075347222892973 0.16037610050070664 6.181286774661664e-08 8.894139661234844e-09 0.1552835054756323 0.05176116386407684 1.0118448714588135e-10 9.994886065197411 -0.28216088020993024 WNLAAVTPHDFIEHILR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WNLAAVTPHDFIEHILR 17 0 P30279;A0A3B3IT44;H0YGD4 P30279 CCND2 G1/S-specific cyclin-D2 0 3537270.0 1333200.0 734070.0 1470000.0 False True 1826120.0683753048 701636.3601551274 1122816.2756003202 1.0 0.38422246833931994 0.6148644303544002 20.800350195738737 -10.209383158298978 5.449733019058632 1.0000245875734688 0.49954344934682493 0.8625923919712984 0.09415918670207385 2.813050569991971e-05 4.080670072697173e-06 0.0911737121814596 0.030389746832436962 6.174713927872227e-11 10.209383158298978 -0.5004811382266439 WNLAAVTPHDFIEHILR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WNLAAVTPHDFIEHILR 17 0 P30279;A0A3B3IT44;H0YGD4 P30279 CCND2 G1/S-specific cyclin-D2 0 56599910.0 20312400.0 20038600.0 16248910.0 False True 16890660.591894727 19930648.08444933 19646481.95452876 1.0 1.1799803788617593 1.1631565176294207 24.009722417100026 -10.053166331068454 4.516140307572343 0.9999909133558366 1.1715684482565896 0.9928399291722612 0.0068683126245143765 799080.0543120422 1778794.3212491453 40.264661356142824 0.0023512061489174467 8.847766830371632e-11 10.053166331068454 0.171577534900753 WNLAAVTPHDFIEHILR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WNLAAVTPHDFIEHILR 17 0 P30279;A0A3B3IT44;H0YGD4 P30279 CCND2 G1/S-specific cyclin-D2 0 104219600.0 40987000.0 32038600.0 31194000.0 False True 53058479.474557176 30255623.74580712 25517012.077468984 1.0 0.5702316396065481 0.48092241485557474 25.6610799962812 -13.999999999999998 0.22083972611404376 3.602995417209584 0.43353340438622523 0.9994987473897966 0.005073217419116358 13.022637373563331 0.14886645360150824 14.789438569617 0.049153736780898655 1.0000000000000041e-14 13.999999999999998 -3.169462012823359 WNLVVWLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WNLVVWLR 8 0 F5H145;Q6N063-4;Q6N063-2;Q6N063 F5H145 OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 0 5417100.0 2110500.0 3306600.0 0.0 False True 3201782.798217425 2716511.3954162803 0.0 1.0 0.8484371260063871 0.0 21.610444011293573 -7.18034520946575 0.9095854589229357 0.9918399166592565 3.9004636811198602e-19 0.9895156925519424 0.04505826783842178 0.09073984046541232 0.142383759022443 0.037869688592371685 0.06646863749559337 6.601684885176313e-08 7.18034520946575 -0.9918399166592565 down WNLVVWLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WNLVVWLR 8 0 F5H145;Q6N063-4;Q6N063-2;Q6N063 F5H145 OGFOD2 2-oxoglutarate and iron-dependent oxygenase domain-containing protein 2 0 6315800.0 2110500.0 1251600.0 2953700.0 False True 2732083.854174567 1181947.3597551761 2416156.9075213233 1.0 0.4326175267092133 0.8843641105046927 21.381570333386023 -9.975629815574816 6.929407303507832 1.0000000272347969 0.6584908186069605 0.4324624200419873 0.18442477055739756 7.762073168610432e-08 1.1519940388030335e-08 0.17856852955358735 0.059522838749743304 1.0577187045523596e-10 9.975629815574816 -0.3415092086278364 WNQLQAFWGTGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WNQLQAFWGTGK 12 0 Q7Z3B4;Q7Z3B4-3 Q7Z3B4 NUP54 Nucleoporin p54 0 26303000.0 7767900.0 7471100.0 11064000.0 False True 10183792.124450596 6356441.002119703 9919203.413382087 1.0 0.6241723048193726 0.9740186457230161 23.27977154000835 -10.492451780392802 8.798032302623193 1.000006879614231 0.7990954761600325 0.3054142854762626 0.1428241705989503 1.927395605189278e-05 1.1116789420797703e-06 0.13829364139371988 0.04609630284713513 3.2177197754810803e-11 10.492451780392802 -0.20091140345419845 WNQLQAFWGTGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WNQLQAFWGTGK 12 0 Q7Z3B4;Q7Z3B4-3 Q7Z3B4 NUP54 Nucleoporin p54 0 24468200.0 7806500.0 3629700.0 13032000.0 False True 7558686.930562055 5079058.138635446 9618528.248380225 1.0 0.6719497956846552 1.2725131146111648 22.849704205450717 -6.758396164355988 1.618590151422796 0.8090670755241236 1.2745276338350406 0.6843302310370123 0.13794875343575075 0.2856326973265614 1.4744898125364059 0.06725827060528987 0.16188388735035622 1.7442303363553445e-07 6.758396164355988 0.46546055831091704 WNQLQAFWGTGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WNQLQAFWGTGK 12 0 Q7Z3B4;Q7Z3B4-3 Q7Z3B4 NUP54 Nucleoporin p54 0 24622800.0 7767900.0 7445500.0 9409400.0 False True 10639902.549604343 7116533.1910240315 7187093.512675963 1.0 0.6688532303605231 0.6754849002769507 23.342981601531243 -10.557469197686386 9.540445502696462 1.0000196656782392 0.6721690653188118 0.9996931854795422 0.0027073679063022 1.1325391141141917e-06 5.253263615742838e-08 0.0026215544438568552 0.0008737992344304005 2.770325517389749e-11 10.557469197686386 -0.32785060035942737 WNQLQAFWGTGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WNQLQAFWGTGK 12 0 Q7Z3B4;Q7Z3B4-3 Q7Z3B4 NUP54 Nucleoporin p54 0 20623500.0 7806500.0 4804400.0 8012600.0 False True 6491450.636587803 4778517.743601262 9687997.613923453 1.0 0.7361247910702845 1.4924241369593003 22.630109480884993 -6.8124501855351385 1.4041802820661744 0.8566010717194653 1.5064136634288618 0.8661351240022603 0.11467344186295 0.20347846902099243 0.7902542636228647 0.06420525638586798 0.14836398800053308 1.5401031689104117e-07 6.8124501855351385 0.6498125917093965 WNQQQLDDLYLIAICHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WNQQQLDDLYLIAICHR 17 0 Q96C86;A0A3B3ITF0 Q96C86 DCPS m7GpppX diphosphatase 0 21326400.0 4316300.0 11789000.0 5221100.0 False True 6548142.66379809 9685160.842122594 4189147.2965105786 1.0 1.4790699194242896 0.639745880869487 22.642654323346367 -6.751852446986744 1.6427062306991174 1.2810589520666718 0.6378075149197813 0.6570599043012739 0.2013301699926563 0.2968034563841325 1.5763096476099627 0.09678927787351174 0.23454910940770354 1.7707104609745542e-07 6.751852446986744 -0.6432514371468905 WNQQQLDDLYLIAICHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WNQQQLDDLYLIAICHR 17 0 Q96C86;A0A3B3ITF0 Q96C86 DCPS m7GpppX diphosphatase 0 3274410.0 776990.0 949220.0 1548200.0 False True 1064264.2003652311 907280.3217492205 1182547.0461798767 1.0 0.8524953873651511 1.111140491030379 20.021424909300332 -6.752024918334985 1.642504053477481 0.9134780698372007 1.1117306813289594 0.6576082403973003 0.061989247844790096 0.29651025463343905 1.5744905134321088 0.029806969899588778 0.07220574129880197 1.7700073984209497e-07 6.752024918334985 0.19825261149175866 WNQQQLDDLYLIAICHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WNQQQLDDLYLIAICHR 17 0 Q96C86;A0A3B3ITF0 Q96C86 DCPS m7GpppX diphosphatase 0 15769200.0 4316300.0 5297700.0 6155200.0 False True 5587535.436992978 5002878.337947429 5035016.757685368 1.0 0.8953640463423725 0.9011158523220111 22.413780645438816 -10.08407007328939 5.299197061259758 1.0000014252271348 0.8982399493322422 0.9976095574151654 0.002348164958642772 3.9539554917846535e-08 6.834616551851409e-09 0.002273632790833907 0.0007578669815267468 8.240051512929726e-11 10.08407007328939 -0.1017614758948926 WNTWSSSYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WNTWSSSYR 9 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 16552100.0 3670700.0 9313900.0 3567500.0 False True 5568720.26411594 7651761.77516715 2862382.0613092044 1.0 1.3740610790730576 0.514010746733679 22.408914392268137 -6.7884993397017865 1.5023770523847155 1.2094700665700708 0.5052443545073807 0.7964147570593547 0.15887072156664983 0.23759288836537343 1.05947200598924 0.0832430498972325 0.19510306835860874 1.627423789963804e-07 6.7884993397017865 -0.7042257120626901 WNTWSSSYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WNTWSSSYR 9 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 15326200.0 5980100.0 5062400.0 4283700.0 False True 8191104.576125979 4838726.428881878 3271978.2855708124 1.0 0.5907294167608316 0.3994550741187472 22.965626582734735 -13.999999999999998 0.10160129619542538 3.0120570315353072 0.001988562616108498 0.9997856718409698 0.003667271447083885 12.06842847287475 0.09524609095054462 5.071139484438802 0.3541766042920589 1.0000000000000041e-14 13.999999999999998 -3.0100684689191985 WNTWSSSYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WNTWSSSYR 9 0 P53674 P53674 CRYBB1 Beta-crystallin B1 0 18385200.0 3670700.0 7030300.0 7684200.0 False True 4751793.510314414 6639057.624869621 6285754.446550208 1.0 1.3971687975200613 1.3228172547704615 22.180040714360587 -10.07309058175283 4.392770685571426 0.9999698952480327 1.3599930261800737 0.9689989514666516 0.030353890336809953 21072636.918092173 0.5218044472146675 6505.292771123504 0.010390944011247419 8.451025618817478e-11 10.07309058175283 0.36002313093204097 WNVLGLQGALLTHFLQPIYLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WNVLGLQGALLTHFLQPIYLK 21 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 4097659100.0 1914659100.0 1008500000.0 1174500000.0 False True 2478563948.5232935 952376088.457252 960753051.3876822 1.0 0.3842451146054429 0.38762487930161754 31.206857335722585 -10.255464118529618 5.599826703635543 1.00004158535534 0.38593499932821557 0.9999772802662735 0.0013797831594435158 7.164061148050795e-07 9.524829387452486e-08 0.0013360593907834786 0.0004453230998172592 5.553104950545042e-11 10.255464118529618 -0.6141065860271244 WPFWLSPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WPFWLSPR 8 0 P26639;P26639-2;A2RTX5-2;A2RTX5;B7ZLP8 P26639 TARS;TARSL2 Threonine--tRNA ligase, cytoplasmic;Probable threonine--tRNA ligase 2, cytoplasmic 0 12470400.0 2709700.0 3942300.0 5818400.0 False True 3552442.9407721283 3354124.2069650395 5216367.782033839 1.0 0.9441739847441479 1.4683888999776742 21.760380046455513 -6.880564458235745 1.0766938752005408 0.9651392185548054 1.5059370569614117 0.9741358460764621 0.03780417113670871 0.12712907097473325 0.2693007102592375 0.027034102113081125 0.06546750171869879 1.316544495931909e-07 6.880564458235745 0.5407978384066062 WPFWLSPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WPFWLSPR 8 0 P26639;P26639-2;A2RTX5-2;A2RTX5;B7ZLP8 P26639 TARS;TARSL2 Threonine--tRNA ligase, cytoplasmic;Probable threonine--tRNA ligase 2, cytoplasmic 0 9439600.0 4911300.0 1458000.0 3070300.0 False True 4755393.4698097 2040187.003369558 2266096.3229743573 1.0 0.42902590843890814 0.47653182378303627 22.181133286531583 -10.076701161005479 7.791770081859305 1.0000000349968652 0.4527788676972487 0.9943793948626266 0.01939420872616137 1.1801804923317534e-08 1.36466277940314e-09 0.01877836325141296 0.0062594539507744755 8.381057862043137e-11 10.076701161005479 -0.5472211672996166 WPFWLSPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WPFWLSPR 8 0 P26639;P26639-2;A2RTX5-2;A2RTX5;B7ZLP8 P26639 TARS;TARSL2 Threonine--tRNA ligase, cytoplasmic;Probable threonine--tRNA ligase 2, cytoplasmic 0 15186900.0 2709700.0 4865000.0 7612200.0 False True 3711549.316889112 4650048.213596384 5814355.138180115 1.0 1.2528590668152264 1.566557424340922 21.823590107978404 -6.9682201944841875 0.2976456375186625 0.9440493160195587 1.885163849087835 0.9999649795724519 0.0013713813867294057 0.07688456603203747 0.011086368545650179 0.005266104856880614 0.028205203278904807 1.075919566302979e-07 6.9682201944841875 0.9411145330682764 WPFWLSPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WPFWLSPR 8 0 P26639;P26639-2;A2RTX5-2;A2RTX5;B7ZLP8 P26639 TARS;TARSL2 Threonine--tRNA ligase, cytoplasmic;Probable threonine--tRNA ligase 2, cytoplasmic 0 11895600.0 4911300.0 2737600.0 4246700.0 False True 4083963.5574807767 2722852.0054289466 5134665.335477714 1.0 0.6667179976279117 1.257275013160272 21.96153856196586 -6.753596801153206 1.6366344970705082 0.8048778177369734 1.2587716813966032 0.6642756710112777 0.14007908921472137 0.293805302056281 1.5494341770444269 0.06758365454398339 0.16345356987619972 1.7636126239451787e-07 6.753596801153206 0.4538938636596298 WPGFYILQWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WPGFYILQWK 10 0 Q92503-3;Q92503;Q92503-2 Q92503-3 SEC14L1 SEC14-like protein 1 0 21076000.0 5331400.0 6470400.0 9274200.0 False True 8088123.577548624 5315706.566534052 7441150.304973747 1.0 0.6572237077694545 0.9200094723613306 22.947373609512006 -10.377311851992573 5.75716969448811 1.0000549726781038 0.7886165900654016 0.4631546675969873 0.10728183915287433 7.571801573922229e-05 8.189500390634287e-06 0.10390215360315236 0.03462506469913186 4.194576776334688e-11 10.377311851992573 -0.2114383826127022 WPGFYILQWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WPGFYILQWK 10 0 Q92503-3;Q92503;Q92503-2 Q92503-3 SEC14L1 SEC14-like protein 1 0 15211300.0 5331400.0 4671800.0 5208100.0 False True 6901602.397605438 4411810.223157751 4260279.239618721 1.0 0.6392443332708447 0.61728842001922 22.718499931604455 -13.999999999999998 0.3982285409771092 7.012383605437153 0.6159455866636566 0.9998352479437516 0.002252200136823944 26.511392717167155 0.20778033893640513 137.63890291259702 0.005645781204279095 1.0000000000000041e-14 13.999999999999998 -6.396438018773496 WPLSLIINR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WPLSLIINR 9 0 B3KTU7;F2Z2B9;Q9BSJ2-3;Q9BSJ2;Q9BSJ2-4 B3KTU7 TUBGCP2 Gamma-tubulin complex component 2 0 3818220.0 617920.0 1910700.0 1289600.0 False True 810099.103945792 1625631.0078502668 1156164.5627166976 1.0 2.0067063399184386 1.4271890403103848 19.627738886168885 -10.544003861028736 5.201518648368656 0.9969548054140053 1.7169476901144165 0.6711292234313146 0.23658694685923948 0.00837909556073864 0.0007345604399863243 0.22973958452002147 0.07635810875965533 2.857565138515756e-11 10.544003861028736 0.7199928847004112 WPLSLIINR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WPLSLIINR 9 0 B3KTU7;F2Z2B9;Q9BSJ2-3;Q9BSJ2;Q9BSJ2-4 B3KTU7 TUBGCP2 Gamma-tubulin complex component 2 0 3813020.0 617920.0 1297000.0 1898100.0 False True 846381.7226601169 1239694.2513945564 1449807.8725965777 1.0 1.4646987502261823 1.7129479923549578 19.690948947691776 -10.412804609036094 0.12542533566332292 3.791830786162565e-14 2.18635777797285 0.9998182720578589 0.0039834905875964725 2.227800503807778 0.06575806118725493 0.97429179711642 0.2884312511430686 3.865408443353464e-11 10.412804609036094 2.186357777972812 WQALLVQIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WQALLVQIR 9 0 Q14204 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 68044000.0 21485000.0 22811000.0 23748000.0 False True 32594315.76389546 18740198.826843534 19054197.39088183 1.0 0.5749529753160809 0.5845865128418513 24.958117053997185 -10.600018689468726 6.437396784247219 1.0011185332935062 0.5797697440789661 0.9996060074514344 0.003932875226015215 6.328575633137699e-05 3.932190023169496e-06 0.003817074021569486 0.001269330021089049 2.51177833708347e-11 10.600018689468726 -0.4213487892145401 WQALLVQIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WQALLVQIR 9 0 Q14204 Q14204 DYNC1H1 Cytoplasmic dynein 1 heavy chain 1 0 56770000.0 21485000.0 23592000.0 11693000.0 False True 27812756.032665506 22279084.460965298 9564993.980311764 1.0 0.8010383593340759 0.3439067300298423 24.729243376089634 -6.957244826792706 0.47267032311649704 1.0117660501490553 0.11435452780031045 0.9996539544836137 0.005109568980906804 0.0807004801764176 0.024882686604088003 0.006352737530798953 0.03772284314045313 1.1034563880709136e-07 6.957244826792706 -0.8974115223487449 down WQAVLAQTDVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WQAVLAQTDVR 11 0 Q15149;Q15149-7;Q15149-8;Q15149-9;Q15149-5;Q15149-4;Q15149-6;Q15149-3;Q15149-2;H0YDN1 Q15149 PLEC Plectin 0 5215400.0 1959300.0 1670500.0 1585600.0 False True 2683706.1580916075 1596691.786395224 1211113.9364570528 1.0 0.5949577533222329 0.45128410679590947 21.355795287259006 -13.999999999999998 0.14438722259930062 2.9436189105693087 0.2825394265213879 0.9995860369133837 0.004726979566895768 11.941061571314041 0.11935336342014796 6.524773981530549 0.1513443115545458 1.0000000000000041e-14 13.999999999999998 -2.661079484047921 WQDEHK(ub)FR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WQDEHKFR 8 1 Q96BX8 Q96BX8 MOB3A MOB kinase activator 3A 1 2037470.0 575840.0 538340.0 923290.0 True False 557560.2743988796 753301.9694060136 681452.6508937209 1.0 1.3510682234636753 1.222204454268936 19.088768248753993 -10.173405528716838 4.469405619232907 0.9999433181363873 1.2866363388710909 0.8683672724648894 0.052608413504080465 3.0376573060536573e-05 5.617825281936528e-06 0.05094815405002285 0.016979292443719336 6.708021892042762e-11 10.173405528716838 0.2866930207347036 WQDEHK(ub)FR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WQDEHKFR 8 1 Q96BX8 Q96BX8 MOB3A MOB kinase activator 3A 1 1549400.0 681300.0 593190.0 274910.0 True False 933195.0214402159 566980.9043829886 209981.9199491733 1.0 0.6075695769443318 0.22501397363340472 19.831819085056534 -7.616807766599623 0.33730004201285435 1.071017203053621 3.8389245433432876e-20 0.9993147878579353 0.008282137145172685 0.12422453511624712 0.044290292158871904 0.026804192826047537 0.07254636196594112 2.4165302356203264e-08 7.616807766599623 -1.071017203053621 down WQDEHK(ub)FR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WQDEHKFR 8 1 Q96BX8 Q96BX8 MOB3A MOB kinase activator 3A 1 2901410.0 575840.0 1497700.0 827870.0 True False 478836.47403736896 1489631.5928298251 1000973.7893616055 1.0 3.110940109198057 2.090429287731094 18.86917352418827 -10.506119365156184 6.134016362535576 0.998504345945776 2.600684698464484 0.7663721470696007 0.41662179826376067 0.008525762979530426 0.0006864514900902627 0.40358799138698237 0.13446410719521085 3.11803247998299e-11 10.506119365156184 1.6021803525187077 WQFDIECDK(ub)TAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WQFDIECDKTAK 12 1 Q13257 Q13257 MAD2L1 Mitotic spindle assembly checkpoint protein MAD2A 1 11978900.0 1761700.0 4857200.0 5360000.0 True False 2309605.760327071 4132524.693217314 4805398.616750542 1.0 1.7892770983702835 2.0806142326515644 21.139215180203006 -10.487779566395032 0.21465237993563338 1.3017292777909837e-17 2.292107989927918 0.9993085544271466 0.012003931224387351 2.1851864968422943 0.1083454256150112 1.3342420651410267 0.16245036160901472 3.2525234289517096e-11 10.487779566395032 2.292107989927918 WQFDIECDK(ub)TAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WQFDIECDKTAK 12 1 Q13257 Q13257 MAD2L1 Mitotic spindle assembly checkpoint protein MAD2A 1 8696900.0 1761700.0 2789300.0 4145900.0 True False 2413048.098152398 2666059.5030183755 3166723.807490733 1.0 1.1048513724445448 1.3123334797658623 21.202425241725898 -6.960252579918939 0.4318601855562648 0.9919192648180385 1.433246658506523 0.9997794486601939 0.001927408871990159 0.07961101691061744 0.020798912787297584 0.0027104821835580144 0.017220122633662644 1.0958406843480908e-07 6.960252579918939 0.4413273936884846 WQFLTLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WQFLTLR 7 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 18431900.0 4875600.0 6620600.0 6935700.0 False True 6391958.81537756 5632832.286896672 6218060.29593223 1.0 0.8812372622529095 0.9727941739820082 22.60782668205784 -10.133074200028291 4.951891926861791 1.0000037179661783 0.9270157181770496 0.4586567904450043 0.0373779526943708 1.53432089957767e-06 2.6864296445103626e-07 0.03619289065820167 0.012063682358269066 7.360813258732288e-11 10.133074200028291 -0.07298799978912862 WQFLTLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WQFLTLR 7 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 14824200.0 6745600.0 2203100.0 5875500.0 False True 6531464.620354758 3082809.319014723 4336530.28877824 1.0 0.47199357237692263 0.6639445424329192 22.638975108353844 -10.09225518908583 5.773970199856192 1.0000024786965676 0.5679690574048804 0.871041226588232 0.07836365537838727 2.500413951383914e-06 3.932009676741345e-07 0.07587571713600923 0.02529176101901456 8.08620618459203e-11 10.09225518908583 -0.4320334212916872 WQFLTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WQFLTLR 7 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 21232400.0 4875600.0 7107900.0 9248900.0 False True 6678241.078135786 6793849.475317926 7064500.307074701 1.0 1.0173112045266883 1.0578384674077592 22.671036743580732 -6.956853150094328 0.47772349470053316 0.9990060825610881 1.0778267885269024 0.9996350367454309 0.0004630113990488731 0.08084495725804984 0.025434828104228955 0.0005688102121631857 0.003343452472762991 1.1044520099923211e-07 6.956853150094328 0.07882070596581425 WQFLTLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WQFLTLR 7 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 13254100.0 6745600.0 2757400.0 3751100.0 False True 5609265.280748954 2742545.3388989507 4535437.66687321 1.0 0.48893129521104833 0.808561806202832 22.41938038378812 -10.434916389487576 6.276649751649618 1.000099721475112 0.6487465507069434 0.6168895814406952 0.13048860969248677 0.00018214342731793208 1.6398301028113143e-05 0.1263806589082646 0.0421150176840634 3.673530166108585e-11 10.434916389487576 -0.3513531707681685 WQFLTLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WQFLTLR 7 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PRS0;Q9P2J5-2;A0A6I8PS05;A0A6I8PLB3;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 13106400.0 2138200.0 6501600.0 4466600.0 False True 2767942.050223198 6139780.244634274 3653724.6311862227 1.0 2.2181751399525083 1.320014857569579 21.400382308277578 -10.236234657914236 4.950960698047102 0.9998727646478764 1.769094998761813 0.494353736454872 0.3666723998480349 0.0005150486948564924 7.945457542416954e-05 0.35508699805323635 0.1183430081767316 5.804507037590325e-11 10.236234657914236 0.7692222341139365 WQFTLPMMSTLYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WQFTLPMMSTLYR 13 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 9921400.0 2138400.0 3556300.0 4226700.0 False True 2070517.6625009796 4976349.135859507 3119600.471717975 1.0 2.403432352201513 1.506676580556095 20.981560078959706 -10.046345775500892 4.932870529421178 0.9999832944872803 1.955054466386541 0.6019631663659872 0.36609901077135343 191614972.73687914 1.7016776943103322 41069.636319289915 0.13397851923886264 8.987817068013306e-11 10.046345775500892 0.9550711718992607 WQFTLPMMSTLYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WQFTLPMMSTLYR 13 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 92417000.0 32646000.0 19775000.0 39996000.0 False True 49526368.74229136 16245996.747219777 32090773.069130484 1.0 0.32802721378090977 0.6479532799207154 25.56169351111689 -10.548849068600093 6.429589484965681 1.000643521333949 0.4879902468511001 0.7735015490581068 0.13060926957640442 0.0012062240829335982 8.463803546509998e-05 0.12660928942190128 0.042153960494144105 2.82586188282158e-11 10.548849068600093 -0.5126532744828489 WQFTLPMMSTLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WQFTLPMMSTLYR 13 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 14681700.0 2138400.0 7910700.0 4632600.0 False True 1778174.347182394 7868083.488948989 5601255.241277718 1.0 4.424809918901574 3.1500034010462397 20.761965354393983 -9.781739164805755 11.849486288622472 0.9999999999980932 3.7874066599739087 0.8643988621477531 0.5204375815866303 0.0 0.0 0.5039115178019374 0.1679705071854569 1.6529542566082203e-10 9.781739164805755 2.7874066599758156 WQFTLPMMSTLYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WQFTLPMMSTLYR 13 0 Q6P2Q9;I3L0J9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 59850000.0 32646000.0 16358000.0 10846000.0 False True 42260890.54886652 15447662.920162331 8872139.289357862 1.0 0.365530936985346 0.20993734808070252 25.33281983320934 -13.999999999999998 0.19740858641822198 4.492734958491424 0.10626796255386409 0.9994870084087079 0.007739745975578765 12.480858653368163 0.1408917130930805 16.813932777772454 0.1010229870667031 1.0000000000000041e-14 13.999999999999998 -4.3864669959375595 WQK(ub)IFK(ub)SR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WQKIFKSR 8 2 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7;A0A2R8Y5M6;C9JM14 P51572-2 BCAP31 B-cell receptor-associated protein 31 2 9300810.0 657440.0 458170.0 8185200.0 True False 636569.9270644612 641119.6703249868 6041250.569263492 1.0 1.007147279610752 9.490317265100296 19.279959476996922 -6.907079349732551 0.9153914713757669 0.7124722222640729 10.520812626703462 0.9897720167601042 0.40460378878410785 0.10638125070254686 0.14947693857246203 0.3265435324879784 0.8841729966172488 1.238570267287407e-07 6.907079349732551 9.808340404439388 up WQK(ub)IFK(ub)SR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WQKIFKSR 8 2 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7;A0A2R8Y5M6;C9JM14 P51572-2 BCAP31 B-cell receptor-associated protein 31 2 8251430.0 657440.0 919990.0 6674000.0 True False 546690.4895302997 915033.8312662826 8069502.542910554 1.0 1.6737694340584792 14.760641894179708 19.060364752431198 -6.917574511549822 0.8425091033030014 0.6852379196679006 16.757683700798545 0.9934804143894272 0.5114318008222167 0.09962029681658097 0.11316094317455767 0.43508175076412703 1.274553065075762 1.2089977383928866e-07 6.917574511549822 16.072445781130643 up WQLSVATEQPELEGPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WQLSVATEQPELEGPR 16 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 7783300.0 1665100.0 3333000.0 2785200.0 False True 2182962.224851337 2835729.391932243 2497014.221524929 1.0 1.2990281552514547 1.1438650623901565 21.05785573470044 -10.155523368759708 4.1320644320618065 0.9999313487608134 1.2214466088197742 0.7308799271026942 0.06334506754108986 44336040.16086114 4.218042785197232 30267.053017313574 0.021684701478907453 6.98999123615325e-11 10.155523368759708 0.22151526005896083 WQLSVATEQPELEGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WQLSVATEQPELEGPR 16 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 11377800.0 2532800.0 2498200.0 6346800.0 False True 2452397.6503846254 3495744.287940896 4684382.680081304 1.0 1.4254394214546062 1.9101236209986672 21.22576149685381 -6.969425678360766 0.27155249492766687 0.8817561078113456 2.4684083304177302 0.9999775502461823 0.0017617112064634312 0.07648949811515575 0.009695075700470302 0.009411438236335433 0.04498275100418569 1.0729372459132958e-07 6.969425678360766 1.5866522226063846 WQLSVATEQPELEGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WQLSVATEQPELEGPR 16 0 Q9NR30-2;Q9NR30 Q9NR30-2 DDX21 Nucleolar RNA helicase 2 0 8340900.0 1665100.0 1947600.0 4728200.0 False True 2280732.467635552 1861548.592148062 3611496.5403356743 1.0 0.8162064681255403 1.5834810051525827 21.12106579622333 -6.843471194302709 1.266137912710048 0.9022253457282993 1.6105083046859385 0.9302663773546431 0.08637728577332572 0.16478181949148465 0.5116253359313283 0.05346060128670168 0.12330465131759474 1.433932822180152e-07 6.843471194302709 0.7082829589576393 WQPDTEEEYEDSSGNVVNKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 WQPDTEEEYEDSSGNVVNKK 20 1 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 1 13723500.0 4376800.0 7387900.0 1958800.0 True False 5738027.184991495 6285654.117808648 1756122.1661363733 1.0 1.0954381907164084 0.3060498163427534 22.452123372488177 -6.876678419009964 1.0980957387942472 1.0569184315936766 0.25353798350762136 0.9709087366014177 0.06000196270664385 0.13061595761445002 0.29037771851238414 0.04220829655580236 0.10126771714134802 1.3283777142998289e-07 6.876678419009964 -0.8033804480860552 down WQPDTEEEYEDSSGNVVNKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 WQPDTEEEYEDSSGNVVNKK 20 1 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 1 13486600.0 5375100.0 4815900.0 3295600.0 True False 5204470.392680991 6738913.984586722 2432383.494119233 1.0 1.2948318418841631 0.4673642677533292 22.31131993155647 -6.810391011359943 1.413057168136042 1.1606074885803026 0.45278249136588994 0.8607937317287612 0.1277621239652357 0.20627651240574973 0.8117304076062515 0.07109497354527688 0.16441542655981717 1.547422789666975e-07 6.810391011359943 -0.7078249972144126 down WQPDTEEEYEDSSGNVVNKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WQPDTEEEYEDSSGNVVNKK 20 1 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 1 13962300.0 4376800.0 6266800.0 3318700.0 True False 5995021.238572634 5989912.054463675 2534891.410771964 1.0 0.999147762133671 0.42283276570601463 22.51533343401107 -6.9072205784809215 0.9144533593722093 1.01945000125109 0.35261707295877043 0.9898297639423103 0.02741829967336876 0.10628483051209872 0.14894905830734131 0.02214369462921931 0.06001124350076435 1.2381675606045358e-07 6.9072205784809215 -0.6668329282923197 down WQPDTEEEYEDSSGNVVNKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WQPDTEEEYEDSSGNVVNKK 20 1 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 1 17514800.0 5375100.0 9445100.0 2694600.0 True False 4469633.807304573 9394217.371594427 3258028.4015772827 1.0 2.1017868077339514 0.7289251294485906 22.091725206990745 -6.693034548616288 1.855328456414601 1.6887863199076458 0.7334568873669278 0.38468814892824066 0.46569788523030675 0.41024285227778423 2.7401433620125846 0.20061196073692214 0.520476707370995 2.0275214214878017e-07 6.693034548616288 -0.955329432540718 WQQHQGLLPPGMTIDLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WQQHQGLLPPGMTIDLFR 18 0 Q2TAY7;Q2TAY7-2 Q2TAY7 SMU1 WD40 repeat-containing protein SMU1;WD40 repeat-containing protein SMU1, N-terminally processed 0 18138900.0 8029300.0 5116700.0 4992900.0 False True 7774414.266516618 7159824.993237999 3685109.7062106794 1.0 0.9209471926488951 0.4740048034334835 22.890302554326396 -6.937105703687717 0.6859592947400504 1.005355732929319 0.36309188815130305 0.9977597260004523 0.010961195237096105 0.08911215702298993 0.06081029184812639 0.010448992753294585 0.0389832039647431 1.1558308882679091e-07 6.937105703687717 -0.642263844778016 down WQQHQGLLPPGMTIDLFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WQQHQGLLPPGMTIDLFR 18 0 Q2TAY7;Q2TAY7-2 Q2TAY7 SMU1 WD40 repeat-containing protein SMU1;WD40 repeat-containing protein SMU1, N-terminally processed 0 27568900.0 6081800.0 9525100.0 11962000.0 False True 9226535.239137037 7825271.485054029 9597705.456869159 1.0 0.8481267650570347 1.0402285590540743 23.137357556118666 -6.695979470222361 1.8452142283787918 0.9053232585004013 1.0396157313556533 0.39850954496027136 0.06415600936332705 0.40395020210727434 2.6710189638902375 0.02776808447103604 0.07176855992703712 2.0138194439989667e-07 6.695979470222361 0.13429247285525203 WQQHQGLLPPGMTIDLFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WQQHQGLLPPGMTIDLFR 18 0 Q2TAY7;Q2TAY7-2 Q2TAY7 SMU1 WD40 repeat-containing protein SMU1;WD40 repeat-containing protein SMU1, N-terminally processed 0 10509200.0 1295700.0 3433300.0 5780200.0 False True 1774755.3049759087 3281605.453595158 4415035.806955763 1.0 1.849046707675402 2.4876870600568197 20.759188695556666 -7.249198019601643 0.13383137886309113 6.315639753695769e-09 4.177905183201836 0.9999973397892183 0.0009938703056446363 0.10183007973866738 0.006934974658282918 0.07224644054489919 0.1357648832954267 5.633807198812963e-08 7.249198019601643 4.177905176886196 WQQHQGLLPPGMTIDLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WQQHQGLLPPGMTIDLFR 18 0 Q2TAY7;Q2TAY7-2 Q2TAY7 SMU1 WD40 repeat-containing protein SMU1;WD40 repeat-containing protein SMU1, N-terminally processed 0 17005800.0 8029300.0 4332400.0 4644100.0 False True 6676718.708301353 4309060.501285926 5615159.838107722 1.0 0.6453859582145268 0.841005901765224 22.670707829760673 -10.108930735548551 5.110702671644714 1.0000071715302064 0.7431959299893733 0.696769515037348 0.07986150753695703 6.525917481583655e-06 1.1378294594796298e-06 0.07732773152878689 0.02577519072422018 7.781606478791524e-11 10.108930735548551 -0.256811241540833 WQQHQGLLPPGMTIDLFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WQQHQGLLPPGMTIDLFR 18 0 Q2TAY7;Q2TAY7-2 Q2TAY7 SMU1 WD40 repeat-containing protein SMU1;WD40 repeat-containing protein SMU1, N-terminally processed 0 19446300.0 6081800.0 8677300.0 4687200.0 False True 7873009.990200835 8194400.627040268 3834177.694733369 1.0 1.0408218251011305 0.487002772701367 22.908483878211115 -6.889159206217378 1.0273639984005827 1.030360023708097 0.4401500796768848 0.9803539189402142 0.03532182263703526 0.1198271635333589 0.2258638054216601 0.02622540683419885 0.06518433909464345 1.2907460176317697e-07 6.889159206217378 -0.5902099440312122 down WQSLK(ub)DLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WQSLKDLVK 9 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 22484100.0 7518000.0 8377100.0 6589000.0 True False 7279345.205145139 11722119.715999397 4863143.234237058 1.0 1.6103261194034382 0.6680742700318324 22.795377251647007 -6.73183601679478 1.7163804447570528 1.366532141485053 0.6684261056260977 0.5678438147473148 0.2565313271187285 0.33279713685852746 1.92150064356457 0.11839790344378792 0.29320506843081195 1.8542316218251785e-07 6.73183601679478 -0.6981060358589554 WQSLK(ub)DLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WQSLKDLVK 9 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 147569000.0 14108000.0 13603000.0 119858000.0 True False 21402867.432954952 11175438.369275887 96168013.7643725 1.0 0.5221467826347681 4.493230361100976 24.351300757762136 -6.876839660289488 1.0973120175578557 0.7145999404574681 4.758102188679115 0.9710438034786452 0.3012159464895091 0.13046446247599738 0.28953826303371144 0.21202822012694636 0.508850302684594 1.3278846167013895e-07 6.876839660289488 4.043502248221647 up WQSLK(ub)DLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WQSLKDLVK 9 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 39324100.0 7518000.0 11708000.0 20098100.0 True False 6251550.103870763 11644926.680143962 24300519.78688505 1.0 1.8627262817479122 3.887119095764574 22.575782527081284 -6.956805380185634 0.47834370883095595 0.950643287398802 4.88336727175645 0.9996327231668959 0.023189902660919214 0.08086279882432088 0.02550335019082793 0.02844813783950984 0.167005607017082 1.1045735000770545e-07 6.956805380185634 3.932723984357648 WQSLK(ub)DLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WQSLKDLVK 9 1 P52272-2;P52272;A0A087X0X3;M0R019;M0R2T0;M0R0N3;M0QYQ7;M0R0Y6 P52272-2 HNRNPM Heterogeneous nuclear ribonucleoprotein M 1 123313300.0 14108000.0 9322300.0 99883000.0 True False 18263084.11025576 8803505.810039705 81705318.88612671 1.0 0.48203828865334064 4.473796342001433 24.122427079854585 -6.874277824344689 1.1112769902972 0.6979589152590722 4.727331239005548 0.9687664157405821 0.3132204336773364 0.13281642715258382 0.30398033682765463 0.21813249504458607 0.5206095608577447 1.3357407508541574e-07 6.874277824344689 4.029372323746476 up WQSLVLTIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WQSLVLTIR 9 0 Q96JB5;Q96JB5-4;J3QQY1;J3QS62;J3QL95;J3KRI2;J3KRK4;J3KS63 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 0 54572000.0 11688000.0 18565000.0 24319000.0 False True 17731550.507256683 15251930.700992951 19512338.990603663 1.0 0.8601577563536285 1.1004305000072152 24.07981536013938 -6.748945432541782 1.653949070343638 0.9176668126264629 1.100864219343796 0.644351350000908 0.05875952448569225 0.3018814381495345 1.624490698533573 0.02806982062312476 0.06821617939277501 1.7826027306652112e-07 6.748945432541782 0.1831974067173332 WQSLVLTIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WQSLVLTIR 9 0 Q96JB5;Q96JB5-4;J3QQY1;J3QS62;J3QL95;J3KRI2;J3KRK4;J3KS63 Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 0 46975000.0 11688000.0 17409000.0 17878000.0 False True 15130346.404924097 16440173.846259084 14624387.443770941 1.0 1.086569560688228 0.9665599882770368 23.85094168223183 -6.713158466376329 1.783972183687493 1.0530482683176896 0.9668150741852656 0.4800928072994105 0.036462416986551074 0.36875449332715576 2.2895954236210767 0.01625344542225134 0.04113362469911786 1.935715526706957e-07 6.713158466376329 -0.08623319413242403 WRPFIIRPTPSPLMKPLLVFVNPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WRPFIIRPTPSPLMKPLLVFVNPK 24 3 Q13574-1;E9PNL8;Q13574-6;Q13574;Q13574-4;Q13574-7;Q13574-5;Q13574-3 Q13574-1 DGKZ Diacylglycerol kinase zeta;Diacylglycerol kinase 0 13596500.0 4702400.0 5502300.0 3391800.0 False True 6087349.498161793 5196092.168089572 2774527.202806928 1.0 0.8535886052967133 0.4557857576018523 22.537382768192302 -6.953654209432481 0.5171727669946011 1.006910443298891 0.28479682830219905 0.9994577306726727 0.005354540534033812 0.08205073734872147 0.03014009789590359 0.006093678243023252 0.03285000775456305 1.1126172541395887e-07 6.953654209432481 -0.7221136149966918 down WRPK(ub)NSVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WRPKNSVGR 9 2 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 1 15859600.0 2023100.0 2891500.0 10945000.0 True False 2652303.6917282715 2460099.4709787234 9812516.3918535 1.0 0.927533102129679 3.699620229182561 21.338814544422462 -6.900896452659507 0.9555674928801888 0.8875645320801046 3.99596979213348 0.9870074971853551 0.14704398121408338 0.1107489484713179 0.17371493936783605 0.11521262128655674 0.3011397816422358 1.2563294703054373e-07 6.900896452659507 3.108405260053375 up WRPK(ub)NSVGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WRPKNSVGR 9 2 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 1 12455700.0 3330600.0 4929200.0 4195900.0 True False 3224871.926078265 6897455.265438423 3096867.9156981697 1.0 2.1388307577927135 0.9603072576789864 21.620810435199367 -6.653949670702918 1.9942308811690481 1.7366559978937053 0.965235145318567 0.2103175507978572 0.48559416497747565 0.498915053409786 3.807507955743949 0.1971664121074597 0.5380622617682409 2.218453495909531e-07 6.653949670702918 -0.7714208525751383 WRPK(ub)NSVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WRPKNSVGR 9 2 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 1 13381900.0 2023100.0 3124500.0 8234300.0 True False 2771094.7422217834 2986449.2586602084 6289527.930731788 1.0 1.0777145989118222 2.2696906875471994 21.402024605945353 -6.920155950263304 0.8235749680497512 0.973847611582191 2.4625952481471276 0.9942240401270929 0.04416247335391521 0.0980799735919032 0.10514116430366025 0.03808196404839542 0.11424321448737504 1.20183279248613e-07 6.920155950263304 1.4887476365649366 up WRYPSLSLHGIEGAFSGSGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WRYPSLSLHGIEGAFSGSGAK 21 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 8888150.0 2661700.0 2453400.0 3773050.0 False True 3489514.475939465 2087362.2832782993 3382650.979651236 1.0 0.5981812936071368 0.9693758266300188 21.73459488602196 -10.458129947439629 8.752118086280298 1.0000039119029123 0.7837785601185778 0.31148962830224813 0.1515395335361235 1.156746895643044e-05 7.162455393127425e-07 0.146730175846529 0.048909174139787244 3.4823310286498077e-11 10.458129947439629 -0.21622535178433444 WRYPSLSLHGIEGAFSGSGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WRYPSLSLHGIEGAFSGSGAK 21 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 45981900.0 12062000.0 10035800.0 23884100.0 False True 11679098.41240498 14043147.276005613 17628137.70235867 1.0 1.2024170685204307 1.5093748746594091 23.477425571464018 -6.965075350747501 0.35675960678492813 0.9725507696425836 1.749707478911672 0.999914686272027 0.0019341805691582372 0.0779354430336149 0.014770029987991698 0.0041465578142794255 0.026269811109690386 1.0837388673807818e-07 6.965075350747501 0.7771567092690884 WRYPSLSLHGIEGAFSGSGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WRYPSLSLHGIEGAFSGSGAK 21 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 51287000.0 10377000.0 16204000.0 24706000.0 False True 15742667.660318514 13312269.597570134 19822848.27097551 1.0 0.8456171396621348 1.2591797463235304 23.90817669642997 -6.805641980432126 1.4330800987349472 0.9154192524359467 1.265694655588807 0.8480537094669635 0.06651344541410945 0.21281165506406127 0.8622178386881393 0.036505725597054346 0.0846122472431671 1.564436786769134e-07 6.805641980432126 0.3502754031528602 WRYPSLSLHGIEGAFSGSGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WRYPSLSLHGIEGAFSGSGAK 21 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 34035600.0 2661700.0 11526700.0 19847200.0 False True 3645802.4197378834 11017412.280300409 15159700.125914747 1.0 3.0219444204254247 4.1581244347862 21.79780494754485 -8.677169807461016 0.25492263731133263 2.1811313271834066e-16 4.9731030732422825 0.9992047670901428 0.03683166261999281 0.2563219647800928 0.07533508373113014 0.6643603958290174 0.44505884171661647 2.102956031331217e-09 8.677169807461016 4.9731030732422825 WRYPSLSLHGIEGAFSGSGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WRYPSLSLHGIEGAFSGSGAK 21 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 34377500.0 12062000.0 12001500.0 10314000.0 False True 10030087.437202597 11936845.537388759 12470609.71345213 1.0 1.1901038362949665 1.2433201396826703 23.257830846898294 -13.999999999998925 0.17861260620362748 0.017780106088095014 1.2862036612551482 0.9994998741367532 0.00233571601833492 12.187024773041976 0.1339612583420854 4.152955621772543 0.040206539111922866 1.0000000000024747e-14 13.999999999998925 1.268423555167053 WRYPSLSLHGIEGAFSGSGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WRYPSLSLHGIEGAFSGSGAK 21 1 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 66498000.0 10377000.0 31286000.0 24835000.0 False True 13433231.061250644 29544906.597395733 20315284.828619063 1.0 2.1993894441837347 1.5123155952569236 23.67930301852242 -10.106088356814906 4.795696830715927 0.9999636188130181 1.8558525197262128 0.6741454233555915 0.2804967243109078 35907784.60469921 75669357.97035852 10642.4063095365 0.09602149621308818 7.832702709349092e-11 10.106088356814906 0.8558889009131947 WSGPLSLQEVDEQPQHPLHVTYAGAAVDELGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WSGPLSLQEVDEQPQHPLHVTYAGAAVDELGK 32 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 86598000.0 32476000.0 13515000.0 40607000.0 False True 31445067.15646367 18911609.979793936 29970808.51611232 1.0 0.6014173824369324 0.9531163780628685 24.906330380932186 -10.236971841981777 7.847100819209662 1.000000229205965 0.7772668802499005 0.3484360739041251 0.14358051372214606 5.757221099196692e-07 5.596658100178019e-08 0.13902137755803073 0.046340411540481456 5.794662656187634e-11 10.236971841981777 -0.22273334895606456 WSGPLSLQEVDEQPQHPLHVTYAGAAVDELGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WSGPLSLQEVDEQPQHPLHVTYAGAAVDELGK 32 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 288262200.0 6855200.0 269264000.0 12143000.0 False True 10399839.582250686 221211735.43076548 9742930.727534037 1.0 21.270687271783075 0.9368347127355897 23.310057939147487 -10.955960601071768 1.034333696764986e-09 8.587519246447924 11.599247843114032 0.0 9.856708873564235 954930678.9148897 2.01437300095142 826359787.0386094 826359788.9362435 1.106724180760483e-11 10.955960601071768 3.0117285966661083 WSGPLSLQEVDEQPQHPLHVTYAGAAVDELGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WSGPLSLQEVDEQPQHPLHVTYAGAAVDELGK 32 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 46410500.0 32476000.0 7369500.0 6565000.0 False True 27005232.930740513 7329799.040768775 7937711.146869618 1.0 0.27142143374831407 0.29393233404900526 24.686735656366462 -10.087171060988807 5.499619015066619 1.0000068470487182 0.2826768838986303 0.9992619311889333 0.009190036565532377 7.715415004307118e-07 1.2804863923265758e-07 0.008898299433433992 0.0029660715473042777 8.181424726733137e-11 10.087171060988807 -0.7173299631500879 WSGPLSLQEVDEQPQHPLHVTYAGAAVDELGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WSGPLSLQEVDEQPQHPLHVTYAGAAVDELGK 32 0 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 38113200.0 6855200.0 19665000.0 11593000.0 False True 8874191.536194017 18570625.46307571 9483192.954225114 1.0 2.092655470341619 1.0686261295518855 23.081184261239937 -6.630923620151328 2.077527269045502 1.7194054520443764 1.0728010466651539 0.12061790451978516 0.46858937709519044 0.5566554094227326 4.579945481156748 0.18441889949842505 0.5189340670459257 2.339248608712471e-07 6.630923620151328 -0.6466044053792226 WSLALGLPLPLGEHAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WSLALGLPLPLGEHAGR 17 0 Q96F86 Q96F86 EDC3 Enhancer of mRNA-decapping protein 3 0 319736100.0 98863100.0 118943000.0 101930000.0 False True 149982550.56074354 97716692.3440992 81783490.82249402 1.0 0.6515204067324054 0.5452867051315504 27.16021942192773 -13.999999999999998 0.16641106221435648 2.7414967853384677 0.44790415205922135 0.9995209888372244 0.0042507273786943295 12.058634704474198 0.1291015750220237 6.777359025126865 0.08952531230870986 1.0000000000000041e-14 13.999999999999998 -2.2935926332792462 WSLALGLPLPLGEHAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WSLALGLPLPLGEHAGR 17 0 Q96F86 Q96F86 EDC3 Enhancer of mRNA-decapping protein 3 0 41361000.0 6894700.0 9171300.0 25295000.0 False True 9443856.912261644 8766081.640566612 19320841.96687762 1.0 0.9282310947749507 2.045863479972041 23.170944752193737 -6.891575716242614 1.01299460388737 0.9421971976965581 2.145018556375724 0.9818885163838462 0.06874047222901698 0.11787476692529936 0.21444461808044155 0.05159411743274254 0.1293790589232443 1.2835839669666916e-07 6.891575716242614 1.202821358679166 up WSLALGLPLPLGEHAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WSLALGLPLPLGEHAGR 17 0 Q96F86 Q96F86 EDC3 Enhancer of mRNA-decapping protein 3 0 60202500.0 34534500.0 11678000.0 13990000.0 False True 28716966.88775269 11615088.2960985 16915244.317548502 1.0 0.4044677956937069 0.589033110065763 24.77540004265243 -10.301444560631813 5.170628978741123 1.00012297374375 0.49675045287966646 0.9083662147528847 0.0753484740715761 0.0001068408110534485 1.4434297761262683e-05 0.0729735145093181 0.02431861543674242 4.995229421715329e-11 10.301444560631813 -0.5033725208640836 WSLALGLPLPLGEHAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WSLALGLPLPLGEHAGR 17 0 Q96F86 Q96F86 EDC3 Enhancer of mRNA-decapping protein 3 0 225733100.0 98863100.0 72361000.0 54509000.0 False True 127980231.83304702 68334046.73956884 44588921.30957097 1.0 0.5339422015480647 0.34840475494479634 26.93134574402018 -13.999999999999662 0.1270911239276968 3.2147356716109656 0.07871187138898986 0.9996589775376309 0.005061868656025424 11.942199642637146 0.11056476124115493 6.625328743892446 0.23961808800630843 1.0000000000007772e-14 13.999999999999662 -3.1360238002219756 WSPTHEQQLISGSLDNIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WSPTHEQQLISGSLDNIVK 19 0 Q9GZL7 Q9GZL7 WDR12 Ribosome biogenesis protein WDR12 0 7450900.0 1819000.0 1723500.0 3908400.0 False True 1761256.840670261 2411702.5379337682 2884672.7905132985 1.0 1.3693076911008475 1.6378490200302143 20.74817387925548 -6.974593900002931 0.09920238508466728 0.32760653391199285 2.6863583430777322 0.9999997531717169 0.00012978048499858683 0.07483816874270832 0.0029104745546456702 0.02449172789353701 0.0442780247635339 1.0602446751747208e-07 6.974593900002931 2.3587518091657396 WSRPQAPITGYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WSRPQAPITGYR 12 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 17408700.0 3665100.0 4977500.0 8766100.0 False True 4804981.592878883 4234876.402143033 7859068.062368833 1.0 0.8813512227433375 1.6356083598772142 22.196099473598284 -6.866684214991338 1.1515708891707501 0.9340771827960874 1.6770701977717368 0.9612560833106564 0.06518302894366294 0.14006947288301674 0.3492555146833911 0.04401355079850944 0.10363899445652001 1.3593014651395296e-07 6.866684214991338 0.7429930149756494 WSRPQAPITGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WSRPQAPITGYR 12 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 10748000.0 2917500.0 1690600.0 6139900.0 False True 2824885.5594587596 2365665.3963625315 4531675.996948267 1.0 0.8374376046638103 1.604198082210638 21.429760992198702 -6.851295587809442 1.2288185165331003 0.9131467963727468 1.635626244518981 0.9421740910758478 0.07932695802984122 0.15603332348643648 0.45273997869474414 0.05049756420807513 0.1169554719821865 1.408329940143299e-07 6.851295587809442 0.7224794481462343 WSRPQAPITGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WSRPQAPITGYR 12 1 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 17793300.0 3665100.0 5097800.0 9030400.0 False True 5020186.5156033 4872562.339829737 6897605.506925952 1.0 0.9705938862401366 1.3739739520608296 22.259309535121176 -6.889367885271912 1.0261452748746902 0.9779962226151433 1.4082378355020884 0.9804895041650272 0.025647612944074666 0.11965628870003882 0.22487056729062943 0.019060295569219652 0.04740942157381029 1.2901259614987097e-07 6.889367885271912 0.43024161288694507 WSSLACNIALDAVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WSSLACNIALDAVK 14 0 P49368;B4DUR8;P49368-2;E9PRC8;Q5SZX6;Q5SZW8;E9PQ35 P49368 CCT3 T-complex protein 1 subunit gamma 0 36472800.0 7222800.0 19123000.0 10127000.0 False True 9469160.745694688 16269922.940870168 9079155.185043417 1.0 1.7182011561338801 0.9588130805754255 23.17480513422808 -6.658799907388484 1.9771613589226447 1.462770086149964 0.9619961202687933 0.23038813150744908 0.30588551577737405 0.48738189182604247 3.661311510147773 0.1250474013549438 0.3390412908741389 2.1938154597200052e-07 6.658799907388484 -0.5007739658811706 WSSLACNIALDAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WSSLACNIALDAVK 14 0 P49368;B4DUR8;P49368-2;E9PRC8;Q5SZX6;Q5SZW8;E9PQ35 P49368 CCT3 T-complex protein 1 subunit gamma 0 14878900.0 9190900.0 3001300.0 2686700.0 False True 8899139.910344314 4199734.74157274 1982972.670727684 1.0 0.47192591462586064 0.22282745194540507 23.085234477645667 -9.70626071316631 0.20266152202942078 1.5460750399717718 1.4143237511008236e-21 0.9994387067764531 0.007676594826098858 1.1485374110683508 0.08551730007259264 0.5079497954627107 0.14154668929272524 1.9667052940439066e-10 9.70626071316631 -1.5460750399717718 WSSLACNIALDAVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WSSLACNIALDAVK 14 0 P49368;B4DUR8;P49368-2;E9PRC8;Q5SZX6;Q5SZW8;E9PQ35 P49368 CCT3 T-complex protein 1 subunit gamma 0 82405000.0 9338000.0 59052000.0 14015000.0 False True 14166428.699243918 48513709.22461813 11244929.107007284 1.0 3.424554646380804 0.7937730352327571 23.755972770578072 -6.664450632029994 1.9570074128338062 2.5549044900143794 0.8046222865814467 0.25471320139038456 1.031233244769677 0.4739923750135459 3.4941921180326387 0.4250344176542615 1.1438825300110638 2.1654560212610997e-07 6.664450632029994 -1.7502822034329326 WSSLACNIALDAVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WSSLACNIALDAVK 14 0 P49368;B4DUR8;P49368-2;E9PRC8;Q5SZX6;Q5SZW8;E9PQ35 P49368 CCT3 T-complex protein 1 subunit gamma 0 30928800.0 7222800.0 13395000.0 10311000.0 False True 9893264.348830733 12803164.6086585 7875754.16171082 1.0 1.294129435667175 0.7960723461959895 23.23801519575097 -6.746627541362496 1.661883433517287 1.1736377439713896 0.795302407187268 0.6346002945995124 0.12358018629076603 0.3059219053936461 1.661199021226367 0.05876459295346853 0.14319810040776626 1.792142168011899e-07 6.746627541362496 -0.3783353367841217 WSSLACNIALDAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WSSLACNIALDAVK 14 0 P49368;B4DUR8;P49368-2;E9PRC8;Q5SZX6;Q5SZW8;E9PQ35 P49368 CCT3 T-complex protein 1 subunit gamma 0 20586000.0 9190900.0 3848800.0 7546300.0 False True 7642640.575906607 3828065.7504730155 9124196.439851059 1.0 0.5008826088905681 1.1938539238146368 22.865639753079943 -6.713445298180163 1.7830666587986925 0.6942386249712021 1.192387312649164 0.48140333737942465 0.210215573130023 0.3681822708833277 2.283917986529831 0.09374947855760873 0.23716529684185675 1.934437496500878e-07 6.713445298180163 0.49814868767796183 WTEECK(ub)VLDAESMHDCVSVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WTEECKVLDAESMHDCVSVVK 21 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 42961400.0 6443400.0 15587000.0 20931000.0 True False 9775108.87563806 12805378.06821313 16793978.675616793 1.0 1.3099985106178442 1.7180349486921274 23.220681340641182 -6.967337691089508 0.3153637820242699 0.9409904631529185 2.100114848222656 0.999953542061387 0.002004210420330139 0.07717638861029456 0.012107932656318286 0.0063055270318792276 0.03604252191211938 1.0781080998357574e-07 6.967337691089508 1.1591243850697377 WTEECK(ub)VLDAESMHDCVSVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WTEECKVLDAESMHDCVSVVK 21 1 Q7Z6Z7-2;Q7Z6Z7-3;Q7Z6Z7 Q7Z6Z7-2 HUWE1 E3 ubiquitin-protein ligase HUWE1 1 34139400.0 6443400.0 12252000.0 15444000.0 True False 8341108.318402453 11570165.429626407 12633350.468821945 1.0 1.3871256657943036 1.514588947484328 22.99180766273363 -12.1261694177639 0.18299283128826596 1.2685374477640467e-16 1.6230418192374578 0.9994553980178272 0.005106388573277217 5.624353817466284 0.1192687973808114 2.20874454930054 0.09199507299873994 7.47877697393332e-13 12.1261694177639 1.6230418192374576 WTFNPAVLTK(ub)ANIVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WTFNPAVLTKANIVR 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 5624600.0 1323300.0 3302300.0 999000.0 True False 1734859.1148554299 2809609.7122645825 895633.0630846627 1.0 1.6195030986701846 0.5162569429502626 20.72638707791897 -6.754311959431503 1.6336566056451531 1.3623687069399666 0.5132891100109735 0.6674261801534753 0.26039588955161946 0.2925724826891556 1.5374646066041915 0.12584259721702298 0.30416936643003084 1.7607108503290067e-07 6.754311959431503 -0.849079596928993 WTFNPAVLTK(ub)ANIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WTFNPAVLTKANIVR 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 14446500.0 6557100.0 7889400.0 0.0 True False 6348948.449675079 11039678.562677499 0.0 1.0 1.738820003057747 0.0 22.598086233324754 -6.8026572186213405 1.520472774731596 1.411568805154348 1.2660727578642364e-21 0.8049355444979873 0.31469875710259737 0.2263808780236055 1.0447793674495705 0.16468716345927104 0.3700776710496452 1.5752256732436544e-07 6.8026572186213405 -1.411568805154348 WTFNPAVLTK(ub)ANIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WTFNPAVLTKANIVR 15 1 Q86YT6 Q86YT6 MIB1 E3 ubiquitin-protein ligase MIB1 1 18010700.0 6557100.0 9739400.0 1714200.0 True False 5452519.178783057 9686931.919080466 2072631.294434713 1.0 1.7765974958464033 0.38012361377833825 22.37849150875903 -6.755745350875129 1.6282982973152358 1.4534622617630608 0.37603360208864484 0.6734452057701097 0.3264712590654679 0.29011894185303455 1.5149621983969939 0.15826696090084616 0.38198377306582143 1.754909193474859e-07 6.755745350875129 -1.077428659674416 WTGMIIGPPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WTGMIIGPPR 10 0 I3L0A0;Q13404;Q13404-7;Q13404-2;Q13404-1;G3V2F7;E5RIF1;D6RG00;H0YBX6;Q13404-8;Q15819;G3V113 I3L0A0;Q15819 TMEM189-UBE2V1;UBE2V1;UBE2V2 Ubiquitin-conjugating enzyme E2 variant 1;Ubiquitin-conjugating enzyme E2 variant 2 0 64673000.0 19631000.0 17796000.0 27246000.0 False True 25736431.10687443 15140906.168264704 24426845.2820868 1.0 0.588306362501848 0.9491154846082048 24.61730867187298 -10.21113713550224 7.782229185495705 1.0000001678972235 0.7687109235550265 0.3539595702851551 0.14729970728368738 4.2905946915626867e-07 4.355769938220925e-08 0.14262243137555264 0.04754077610091238 6.149826513349803e-11 10.21113713550224 -0.231289244342197 WTGMIIGPPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WTGMIIGPPR 10 0 I3L0A0;Q13404;Q13404-7;Q13404-2;Q13404-1;G3V2F7;E5RIF1;D6RG00;H0YBX6;Q13404-8;Q15819;G3V113 I3L0A0;Q15819 TMEM189-UBE2V1;UBE2V1;UBE2V2 Ubiquitin-conjugating enzyme E2 variant 1;Ubiquitin-conjugating enzyme E2 variant 2 0 47178000.0 15538000.0 5438000.0 26202000.0 False True 15044754.695071176 7609421.758795378 19338910.156849172 1.0 0.5057856982731866 1.2854254222692516 23.8427572479124 -6.735429188441549 1.703598029961051 0.7043955281114821 1.28542718768131 0.5841837275299189 0.2076821170991882 0.32614763111050393 1.856744349350277 0.0965173434591859 0.23802836636128036 1.8389537701690719e-07 6.735429188441549 0.5810316595698278 WTGMIIGPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WTGMIIGPPR 10 0 I3L0A0;Q13404;Q13404-7;Q13404-2;Q13404-1;G3V2F7;E5RIF1;D6RG00;H0YBX6;Q13404-8;Q15819;G3V113 I3L0A0;Q15819 TMEM189-UBE2V1;UBE2V1;UBE2V2 Ubiquitin-conjugating enzyme E2 variant 1;Ubiquitin-conjugating enzyme E2 variant 2 0 54114000.0 19631000.0 17344000.0 17139000.0 False True 26889111.207827486 16577684.731061796 13091121.188784987 1.0 0.6165203677775706 0.48685585356849315 24.68051873339587 -13.999999999999998 0.15141323899612646 2.8584354218969343 0.346491312111015 0.9995615907578832 0.004561702642304589 11.963278816779525 0.12261897587890287 6.538676604410683 0.12669268844561535 1.0000000000000041e-14 13.999999999999998 -2.511944109785919 WTGMIIGPPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WTGMIIGPPR 10 0 I3L0A0;Q13404;Q13404-7;Q13404-2;Q13404-1;G3V2F7;E5RIF1;D6RG00;H0YBX6;Q13404-8;Q15819;G3V113 I3L0A0;Q15819 TMEM189-UBE2V1;UBE2V1;UBE2V2 Ubiquitin-conjugating enzyme E2 variant 1;Ubiquitin-conjugating enzyme E2 variant 2 0 39587000.0 15538000.0 11691000.0 12358000.0 False True 12920535.450112244 11628018.2625182 14942000.663063921 1.0 0.8999641158383404 1.1564536718123486 23.623162523346675 -6.800979533662289 1.4523758782593807 0.9448739691103563 1.1600614186784513 0.834874356509318 0.04289191695330269 0.21937090871043247 0.9135315861722566 0.02323407089885154 0.05399068811171689 1.581322558105603e-07 6.800979533662289 0.215187449568095 WTGMIIGPPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WTGMIIGPPR 10 0 I3L0A0;Q13404;Q13404-7;Q13404-2;Q13404-1;G3V2F7;E5RIF1;D6RG00;H0YBX6;Q13404-8;Q15819;G3V113 I3L0A0;Q15819 TMEM189-UBE2V1;UBE2V1;UBE2V2 Ubiquitin-conjugating enzyme E2 variant 1;Ubiquitin-conjugating enzyme E2 variant 2 0 36868100.0 6994300.0 19952000.0 9921800.0 False True 9054259.228264933 18841653.660782438 8116134.206265048 1.0 2.0809713070688236 0.8963885395426592 23.11016518162878 -6.666605770732602 1.9496864137718375 1.691981275677222 0.9012623201172498 0.2640584895631126 0.4595344672577547 0.4689060777884309 3.4331167322071985 0.18998463602150187 0.509796467392501 2.1547368018863402e-07 6.666605770732602 -0.7907189555599721 WTLGFCDER ddPTM_RPMI8226_Bortezomib_1h_R1 1 WTLGFCDER 9 0 O95336;M0R261;M0R1L2;M0R0U3 O95336 PGLS 6-phosphogluconolactonase 0 7387700.0 1805600.0 2359800.0 3222300.0 False True 2367159.0854552737 2007727.038428354 2888887.3064841926 1.0 0.8481588967824736 1.2204026861712065 21.174725235297434 -6.795991955708563 1.4725618096206425 0.9157917518142495 1.2250271819914527 0.8200791249221356 0.06482377687262739 0.2265355486925441 0.970221315914849 0.034640777054215185 0.08075419805281765 1.599587656967453e-07 6.795991955708563 0.3092354301772031 WTLGFCDER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WTLGFCDER 9 0 O95336;M0R261;M0R1L2;M0R0U3 O95336 PGLS 6-phosphogluconolactonase 0 5729300.0 1805600.0 1827900.0 2095800.0 False True 2473179.114505288 1747137.3339430257 1600815.2043558885 1.0 0.7064338056617088 0.647270225988505 21.237935296820325 -13.999999999999995 0.2251774103148279 2.812788551996073 0.6171518712669926 0.9995035997111121 0.003436388115234371 13.14565158611446 0.15028615333066891 10.626037341442444 0.03165971424395294 1.0000000000000123e-14 13.999999999999995 -2.1956366807290806 WTLLSLVLSQHVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WTLLSLVLSQHVK 13 0 O94822-3;O94822 O94822-3 LTN1 E3 ubiquitin-protein ligase listerin 0 60653000.0 11397000.0 21928000.0 27328000.0 False True 17290082.232307028 18014777.075754005 21926608.82171212 1.0 1.0419139038039313 1.2681610490401027 24.043441394722063 -6.938112287296641 0.67689510686961 0.9973584560411376 1.3259278328731572 0.997906084108108 0.0053896541627405795 0.08863838812542618 0.05861061164365944 0.005174233254447497 0.019640087295178552 1.1531550698140263e-07 6.938112287296641 0.3285693768320196 WTLLSLVLSQHVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WTLLSLVLSQHVK 13 0 O94822-3;O94822 O94822-3 LTN1 E3 ubiquitin-protein ligase listerin 0 30165900.0 11397000.0 10516000.0 8252900.0 False True 14753641.16845654 9930775.355693066 6750956.881904984 1.0 0.6731067430950661 0.45757903454630644 23.814567716814512 -8.369585279433602 0.13764057036400573 1.4341780855740973 1.447516700555565e-14 0.9999388087606177 0.0017443474278057854 0.10537268038242396 0.03101656228212428 0.15095070272357267 0.14337706754205742 4.269870666817065e-09 8.369585279433602 -1.4341780855740829 WTNQLNSLNQAVVSK(ub)LA ddPTM_RPMI8226_Bortezomib_1h_R1 1 WTNQLNSLNQAVVSKLA 17 1 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 1 4065750.0 1615800.0 1810400.0 639550.0 True False 2118329.44742946 1540295.376883927 573375.5009967932 1.0 0.7271273968990221 0.27067343169523045 21.014495547328426 -7.060783923821357 0.40707899383097534 1.0247318110479666 9.755217830949608e-14 0.9998365196741767 0.003846954392702952 0.07370791085143337 0.018978707142161103 0.006212151753784099 0.035975153465549255 8.693928740292299e-08 7.060783923821357 -1.0247318110478691 down WTNQLNSLNQAVVSK(ub)LA ddPTM_RPMI8226_Bortezomib_2h_R1 1 WTNQLNSLNQAVVSKLA 17 1 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 1 25924600.0 6650500.0 9046100.0 10228000.0 True False 6439383.517799643 12658254.904788317 7548979.9665771155 1.0 1.9657557077938543 1.172314080332433 22.61849114611351 -10.21035676346934 4.458962236594872 0.9998415184557967 1.569034894070954 0.406803760548907 0.32392118811291637 227940794.83406734 124.93019766926022 401246.5301045836 0.1108868384709232 6.160886904710895e-11 10.21035676346934 0.5691933756151573 WTNQLNSLNQAVVSK(ub)LA ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WTNQLNSLNQAVVSKLA 17 1 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 1 8490800.0 1615800.0 2813200.0 4061800.0 True False 2213204.9253531494 2688903.521991643 3102486.4953968637 1.0 1.214936534429856 1.4018071529918614 21.077705608851318 -6.972763340863846 0.18036224619845234 0.8562307677944114 1.7655680151951727 0.9999966847214296 0.0002988641966568662 0.07541589422560159 0.005690343976302184 0.007173131820608242 0.02094794091022348 1.064723057362461e-07 6.972763340863846 0.9093372474007613 WTNQLNSLNQAVVSK(ub)LA ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WTNQLNSLNQAVVSKLA 17 1 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 1 26769400.0 6650500.0 14247000.0 5871900.0 True False 5530185.417104613 14170248.583191905 7099687.141401926 1.0 2.562346018157722 1.2838063475128547 22.398896421547786 -6.596511974664633 2.2034828759634095 2.053046265338026 1.2877606299937598 0.010760963235041276 0.6758871370964078 0.6506737771446722 5.965134262195151 0.25508231744423593 0.752517935130125 2.5321418163714385e-07 6.596511974664633 -0.7652856353442661 WTSQDSLLGMEFSGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WTSQDSLLGMEFSGR 15 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 13560400.0 2720800.0 5801500.0 5038100.0 False True 3566995.148264681 4935938.814069874 4516805.740867706 1.0 1.3837806357743925 1.2662775117776937 21.76627782281344 -10.214930026764364 4.846330016383755 0.9999490441964775 1.3250290737767214 0.9107300405406594 0.047970449498262624 2.641622390020286e-05 4.279148880730273e-06 0.0464544541713336 0.015482396001056258 6.096351133282692e-11 10.214930026764364 0.32508002958024396 WTSQDSLLGMEFSGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WTSQDSLLGMEFSGR 15 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 8448500.0 2796600.0 1231200.0 4420700.0 False True 2707823.463781444 1722824.580623183 3262786.0518427305 1.0 0.6362396233236263 1.2049478466688104 21.36870225497673 -6.734014316136773 1.7093883688764286 0.7820650563824726 1.2048143000318636 0.5774390638434276 0.1528730454257922 0.3287573779712486 1.8838610412837975 0.0708315949172811 0.17491733694700748 1.8449546008664495e-07 6.734014316136773 0.42274924364939104 WTSQDSLLGMEFSGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WTSQDSLLGMEFSGR 15 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 11333400.0 2720800.0 3456800.0 5155800.0 False True 3726753.286855332 3304067.145891054 3938106.2270341073 1.0 0.8865805948423958 1.0567123509152698 21.82948788433633 -6.7270523150616555 1.7344036367662747 0.9315199447420691 1.0565499831808658 0.5453706817942452 0.047690804126131976 0.34178543174677917 2.01291649209045 0.021804623798544216 0.054279401105186684 1.8747686600549862e-07 6.7270523150616555 0.12503003843879668 WTTLNSLQLHGLQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WTTLNSLQLHGLQLR 15 0 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 0 34494600.0 12678000.0 12343000.0 9473600.0 False True 12275543.829586327 17271624.26789468 6992179.958092002 1.0 1.4069946315752528 0.5696024595863165 23.549283604260086 -6.774521970759947 1.5569341505411884 1.2320871215205407 0.5640407827689606 0.7476373151511899 0.17176013322137965 0.2591737944676729 1.2404019774507669 0.08692185571470719 0.2060817836282665 1.6806529000936486e-07 6.774521970759947 -0.66804633875158 WTTLNSLQLHGLQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WTTLNSLQLHGLQLR 15 0 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 0 39059400.0 8076400.0 10597000.0 20386000.0 False True 12252489.263929501 8705882.55526109 16356698.164498769 1.0 0.7105399048086187 1.3349693937420357 23.546571546818626 -6.7806815650262005 1.533467376800649 0.8362441162313237 1.3399994948507508 0.7697061737317232 0.12244274588007466 0.24952011911751415 1.1590316390532334 0.06288961607087973 0.14829309980403646 1.6569844583159993e-07 6.7806815650262005 0.5037553786194271 WTTLNSLQLHGLQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WTTLNSLQLHGLQLR 15 0 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 0 30397200.0 2273500.0 9735700.0 18388000.0 False True 3114074.3890273413 9305544.582345383 14045133.112747408 1.0 2.9882216735522182 4.510211176148013 21.57037197726039 -7.777911148478295 0.22307316676265534 3.0365790569633015e-20 6.288878578028769 0.9998233318737828 0.01910336628103177 0.13062319697952515 0.032788062898097624 0.2810551064577049 0.4752864906381705 1.6675883465343092e-08 7.777911148478295 6.288878578028769 WTTLNSLQLHGLQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WTTLNSLQLHGLQLR 15 0 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 0 28987900.0 12678000.0 7627000.0 8682900.0 False True 10542318.73062962 7585911.837159025 10498454.244806433 1.0 0.7195676806013217 0.995839199426238 23.329688879694363 -10.82922897417821 9.57130917694034 1.0033013526217704 0.8577034400443727 0.26129288732549893 0.11278737526412703 0.008087335700589117 0.00014429380499827782 0.11115412682957464 0.0364019688383675 1.4817366594006364e-11 10.82922897417821 -0.14559791257739774 WTTLNSLQLHGLQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WTTLNSLQLHGLQLR 15 0 Q08J23-2;Q08J23;Q08J23-3 Q08J23-2 NSUN2 tRNA (cytosine(34)-C(5))-methyltransferase 0 47719400.0 8076400.0 24505000.0 15138000.0 False True 10455059.009644857 23141275.20837376 12383039.328996785 1.0 2.2134045524779715 1.1844064502719072 23.317697868911075 -6.605922902935251 2.169029911917261 1.8129086718083987 1.1879765105335511 0.037796561582222776 0.5236875605143368 0.6240334468514677 5.557392022320496 0.1998075087287399 0.5817275889934435 2.4778618949587184e-07 6.605922902935251 -0.6249321612748475 WVAIQSVSAWPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WVAIQSVSAWPEK 13 0 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;A0A087WYZ1;J3KSV5;J3QRD0;J3QKQ0;J3QLU1;J3QR27;J3QL02;J3QQN6;J3KSS4 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 34693400.0 7293400.0 17144000.0 10256000.0 False True 9441450.074407378 16189921.329212816 8389513.235446623 1.0 1.7147706339197082 0.888583127520612 23.170577023667235 -6.6779336280115995 1.90986580274835 1.4530953222232916 0.8918230457169173 0.31445155043481543 0.30307691117101493 0.44310580157837864 3.1232516010891977 0.12743800105194777 0.3369230898048174 2.0992606831390472e-07 6.6779336280115995 -0.5612722765063743 WVAIQSVSAWPEKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WVAIQSVSAWPEKR 14 1 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;A0A087WYZ1;J3KSV5;J3QRD0;J3QKQ0;J3QLU1;J3QR27;J3QL02;J3QQN6;J3KSS4 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 43418000.0 14898000.0 12346000.0 16174000.0 False True 19531422.27243722 10504024.92433108 14500469.631963288 1.0 0.5378013325304211 0.7424174967752543 24.219293673890956 -10.286901048460255 5.681695866995718 1.0000319564935551 0.6401094146528336 0.8048693245653138 0.08353419925424108 3.381750507555933e-05 4.24431565211716e-06 0.08088880748264987 0.026960546879201804 5.165340452244625e-11 10.286901048460255 -0.3599225418407216 WVAIQSVSAWPEKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WVAIQSVSAWPEKR 14 1 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;A0A087WYZ1;J3KSV5;J3QRD0;J3QKQ0;J3QLU1;J3QR27;J3QL02;J3QQN6;J3KSS4 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 148151000.0 0.0 97720000.0 50431000.0 False True 0.0 80281102.51015514 40463290.74530748 0.0 WVAIQSVSAWPEKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WVAIQSVSAWPEKR 14 1 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;A0A087WYZ1;J3KSV5;J3QRD0;J3QKQ0;J3QLU1;J3QR27;J3QL02;J3QQN6;J3KSS4 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 48787000.0 14898000.0 15196000.0 18693000.0 False True 20406193.203311786 14524590.47354791 14278098.394419607 1.0 0.7117736428757652 0.6996943649490865 24.282503735413847 WVAIQSVSAWPEKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WVAIQSVSAWPEKR 14 1 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;A0A087WYZ1;J3KSV5;J3QRD0;J3QKQ0;J3QLU1;J3QR27;J3QL02;J3QQN6;J3KSS4 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 17202500.0 0.0 7776200.0 9426300.0 False True 0.0 7734308.067145148 11397295.747713171 0.0 WVAIQSVSAWPEKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WVAIQSVSAWPEKR 14 1 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;A0A087WYZ1;J3KSV5;J3QRD0;J3QKQ0;J3QLU1;J3QR27;J3QL02;J3QQN6;J3KSS4 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 129272000.0 0.0 71797000.0 57475000.0 False True 0.0 67801433.83536464 47015139.74330096 0.0 WVAVLSQDYPTLAFHASLTNPFGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WVAVLSQDYPTLAFHASLTNPFGK 24 0 Q13823;H0YG10 Q13823 GNL2 Nucleolar GTP-binding protein 2 0 260225000.0 85624000.0 69381000.0 105220000.0 False True 129897867.9528873 56999418.47377278 84423220.8804358 1.0 0.43880180153877446 0.6499199887642134 26.952802510754292 -10.154801113189952 5.3060480497333 1.0000149264003177 0.5443608951513008 0.8613141469505475 0.08618863902130085 1.5219243385559007e-05 2.424384743545062e-06 0.0834545213737736 0.027817263630049452 7.001625647037733e-11 10.154801113189952 -0.45565403124901693 WVAVLSQDYPTLAFHASLTNPFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WVAVLSQDYPTLAFHASLTNPFGK 24 0 Q13823;H0YG10 Q13823 GNL2 Nucleolar GTP-binding protein 2 0 151371000.0 85624000.0 13282000.0 52465000.0 False True 110841955.90137075 12542845.024183657 42916908.336359955 1.0 0.11315972297840464 0.38719010312799085 26.72392883284674 -10.276857595687439 5.547463872634561 1.0000730051678486 0.2501749135004587 0.9089502283549699 0.1118724342313027 0.00010102161553111048 1.3168815688654994e-05 0.10833046966722114 0.03610667288978294 5.286185563528964e-11 10.276857595687439 -0.7498980916673899 WVDVVHLALYNLGVQSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WVDVVHLALYNLGVQSK 17 0 A0A087X169;Q5T6S3;B0QZ50;F5H8K3 A0A087X169 PHF19 PHD finger protein 19 0 6268200.0 3014200.0 1682500.0 1571500.0 False True 3901941.3187647355 1588867.3959636337 1285503.1249516758 1.0 0.4071992032075542 0.3294521931351434 21.89576065076581 -13.999999999998975 0.28634024607693087 6.004296333831708 0.30747365527097387 0.9996192797670937 0.005843095228968161 15.751803996429507 0.16961873752241333 46.33431497969245 0.029856873399161998 1.0000000000023601e-14 13.999999999998975 -5.696822678560734 WVELAK(ub)LYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WVELAKLYR 9 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 6713000.0 2341500.0 1637000.0 2734500.0 True False 2267170.364172299 2290662.6368422266 2018252.4167584192 1.0 1.0103619353186561 0.890207656492213 21.112461374303056 -6.885912043523024 1.0462417230204049 1.0071027681172173 0.8806637238149085 0.9781509506670654 0.008035737839822026 0.12252353640925683 0.24171426634850476 0.005881242275418548 0.014462320974795117 1.3004329244985207e-07 6.885912043523024 -0.1264390443023088 WVELAK(ub)LYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WVELAKLYR 9 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 17446200.0 2803300.0 3802900.0 10840000.0 True False 4252811.048681786 3124242.7828066857 8697469.24865921 1.0 0.7346300475247037 2.0451106689433343 22.01998532713633 -6.853991783528666 1.2156707043963846 0.8577497888647454 2.1016766245170997 0.9459182073790481 0.1315537754305788 0.15311717957475166 0.43344645666892634 0.08458345931613533 0.1962979439449256 1.3996138017897795e-07 6.853991783528666 1.2439268356523543 up WVELAK(ub)LYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WVELAKLYR 9 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 15074400.0 2803300.0 6123000.0 6148100.0 True False 3628927.1113042235 5782249.667450421 5029208.884833209 1.0 1.593377185625616 1.3858666020508 21.791111649228778 -10.11281934566104 4.487516837013955 0.9999605739707771 1.4896218936749783 0.8812775570821176 0.08471584133272275 59511154.17496794 34824765.28065913 33944.07225691307 0.03100282468000635 7.71224210017918e-11 10.11281934566104 0.48966131970420124 WVESLK(ub)GILADEDSSRPVWLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WVESLKGILADEDSSRPVWLK 21 2 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 56308500.0 3870500.0 10738000.0 41700000.0 True False 5871831.471452517 8821720.003623063 33457976.722240712 1.0 1.5023796317234612 5.698047855239993 22.485379131035817 -6.929304418922437 0.7524797299024111 0.9345217077177246 6.544335288407726 0.9963997371963985 0.12638130473009015 0.0930007552280714 0.07946148420214487 0.11466635417137014 0.38109855034003276 1.1767808192867718e-07 6.929304418922437 5.609813580690002 up WVESLK(ub)GILADEDSSRPVWLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WVESLKGILADEDSSRPVWLK 21 2 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 5430800.0 1449300.0 2309900.0 1671600.0 True False 1205157.1648762836 2297456.1102207494 2021123.8313948575 1.0 1.9063539405307328 1.6770624531799863 20.20078987030414 -10.6526955398209 7.347782774628268 0.9977784944061308 1.7917081968553594 0.9408150735584151 0.09360785772885875 0.00341130520309885 0.0001612404646429949 0.09076127559746436 0.030211806171501952 2.2248690784451293e-11 10.6526955398209 0.7939297024492287 WVESLK(ub)GILADEDSSRPVWLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WVESLKGILADEDSSRPVWLK 21 2 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 58829000.0 3870500.0 6535500.0 48423000.0 True False 5010438.54896122 6171793.679833787 39610510.86193766 1.0 1.2317871219303431 7.905597578908504 22.256505453128266 -6.914270116255135 0.8661550788801397 0.8202141979975508 8.85173203525228 0.9924355986437375 0.27849768085281595 0.10166139997773514 0.12395326842051059 0.23293789377999466 0.6637235928854069 1.2182316649803286e-07 6.914270116255135 8.031517837254729 up WVFK(ub)EEGVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WVFKEEGVLR 10 1 A0A0C4DGS1;P39656;P39656-3;P39656-2 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 1 21814300.0 3716300.0 5706000.0 12392000.0 True False 3598328.090699775 7984435.556396916 9146163.447968675 1.0 2.2189292791375688 2.5417814099853246 21.778895304897965 -10.276858187124418 0.2984468456657259 1.673143951484187e-10 2.650599299684593 0.9990005625040353 0.020989098191146024 1.7585439381910248 0.1401434939419895 1.5141703013878096 0.11611034550848388 5.2861783646267825e-11 10.276858187124418 2.6505992995172782 WVFK(ub)EEGVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WVFKEEGVLR 10 1 A0A0C4DGS1;P39656;P39656-3;P39656-2 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 1 61654500.0 6570500.0 20082000.0 35002000.0 True False 9967928.867892722 16498210.198617833 28083839.358078383 1.0 1.6551292066057501 2.8174197198114106 23.24886234251107 -6.962318872887139 0.4014181790636576 0.937098289861746 3.577987716160893 0.9998467689865801 0.009302882155157038 0.07888294769723615 0.018145324098699032 0.014953133465458983 0.09732991356025653 1.0906392601990163e-07 6.962318872887139 2.640889426299147 WVFK(ub)EEGVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WVFKEEGVLR 10 1 A0A0C4DGS1;P39656;P39656-3;P39656-2 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 1 19041500.0 3716300.0 7383500.0 7941700.0 True False 3090268.110004647 7343723.619990004 9602272.751728015 1.0 2.376403392383634 3.1072620270846256 21.55930058033224 -9.013616205065071 0.2198704855369945 2.6208780378352825e-16 3.7548749063795035 0.9994215337400771 0.02101215679950015 0.48224922629902656 0.07405602087250199 0.7106456122195791 0.3558941470738147 9.69133921454051e-10 9.013616205065071 3.754874906379503 WVFK(ub)EEGVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WVFKEEGVLR 10 1 A0A0C4DGS1;P39656;P39656-3;P39656-2 A0A0C4DGS1 DDOST Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 1 51953500.0 6570500.0 21862000.0 23521000.0 True False 8505641.773918023 20645360.481757488 19240419.345840514 1.0 2.42725487747028 2.262077319649172 23.01998866460352 -10.317673835210092 6.30891360758255 0.9999333472445141 2.3446660985596943 0.9888095617774095 0.06743345560346466 6.323105705010785e-05 6.8387184016661995e-06 0.06529533778837966 0.021764054210786112 4.812006051058233e-11 10.317673835210092 1.3447327513151803 WVIYNDQK(ub)VCASEKPPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WVIYNDQKVCASEKPPK 17 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 51416400.0 14994000.0 17925400.0 18497000.0 True False 19657279.202102553 15251000.192661949 16583107.87575277 1.0 0.7758449191193608 0.8436115550507637 24.22856031380082 -10.067301824806492 6.758064644923371 1.0000000946541763 0.809728237085062 0.9131286772559085 0.027665613269483028 3.943103494036603e-08 5.4929682366294705e-09 0.026787128036027678 0.00892903828794344 8.564424303064803e-11 10.067301824806492 -0.19027185756911424 WVIYNDQK(ub)VCASEKPPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WVIYNDQKVCASEKPPK 17 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 27461600.0 11086000.0 8562600.0 7813000.0 True False 10734080.99816959 11981690.833369104 5766540.9150241455 1.0 1.1162288448738427 0.5372179431110568 23.355695343890964 -6.854483705244518 1.213165601828773 1.0623536380320877 0.5119775179593664 0.9465893130141965 0.05779895980420979 0.1525946471701968 0.42991458005647 0.03723183168830666 0.08644611589794848 1.3980293684860295e-07 6.854483705244518 -0.5503761200727213 WVIYNDQK(ub)VCASEKPPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WVIYNDQKVCASEKPPK 17 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 135640900.0 47100600.0 61404300.0 27136000.0 True False 71455053.71510057 50446222.91101429 21772557.70586868 1.0 0.7059853752562991 0.3047028386918348 26.09053271488711 -7.0837452183313605 0.34702704878810814 1.043548860268447 1.1289222897919855e-12 0.9999175639009124 0.0025874290869914874 0.07490541591877041 0.015103467694657395 0.006309251079256856 0.03405117665174742 8.246217428199636e-08 7.0837452183313605 -1.0435488602673182 down WVIYNDQK(ub)VCASEKPPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WVIYNDQKVCASEKPPK 17 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 61024300.0 14994000.0 19192000.0 26838300.0 True False 20537686.997614253 18344033.980543 20499646.292138822 1.0 0.8931888962313002 0.9981477609684163 24.29177037532371 -10.710135506129912 6.384269580234696 1.0007664515153045 0.9456683287014431 0.26323141130086825 0.04284927709795575 0.000473990553876536 2.152057034085522e-05 0.04206900443817274 0.013829544716450749 1.949236315077127e-11 10.710135506129912 -0.055098122813861394 WVIYNDQK(ub)VCASEKPPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WVIYNDQKVCASEKPPK 17 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 29260940.0 11086000.0 8798540.0 9376400.0 True False 9218500.19307146 8751140.518646553 11336961.888424711 1.0 0.9493019835508416 1.2298054619498155 23.13610061932524 -6.860124935808842 1.1850839368463306 0.9724837362661146 1.243422498317975 0.9537928409819618 0.02623541277160218 0.14667520907475984 0.3913537107840465 0.017265524521493793 0.04030910480617184 1.3799872192154496e-07 6.860124935808842 0.2709387620518603 WVIYNDQK(ub)VCASEKPPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WVIYNDQKVCASEKPPK 17 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 143382600.0 47100600.0 77253000.0 19029000.0 True False 60972655.1916298 72953802.63915525 15565917.254028263 1.0 1.1965003395353235 0.2552934131719611 25.86165903697956 -6.85221705129536 1.2243676688834506 1.1050903259798726 0.21603176679335712 0.9434691029678749 0.09638648860738208 0.15503270960020815 0.44611674265489704 0.061564864287327874 0.1426793280704679 1.4053449865673393e-07 6.85221705129536 -0.8890585591865154 down WVSELSYVEEK(ub)EQWQEQINQLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WVSELSYVEEKEQWQEQINQLK 22 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 17751700.0 10979000.0 3362800.0 3409900.0 True False 10630477.654600762 4705583.576770329 2516744.895192738 1.0 0.44265024862112384 0.23674805375311775 23.341703086521928 -13.2930794292235 0.1479039840715046 3.1826000092003106 6.535658260055547e-18 0.9995825583001405 0.006587472472222955 9.263498369645978 0.11495220479236311 6.009761224988979 0.20572543848926247 5.092377267554009e-14 13.2930794292235 -3.1826000092003106 WVSSLAVHPAGDNVICGSYDSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WVSSLAVHPAGDNVICGSYDSK 22 0 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 55577000.0 10071000.0 28962000.0 16544000.0 False True 15278443.288721938 23793504.818861164 13274071.1485072 1.0 1.5573252044876047 0.8688104473513802 23.86499421975459 -6.6913599519211715 1.8617166924003086 1.3489618033335908 0.871158215247459 0.37676668609235375 0.23564450562042516 0.41373631675312916 2.781366985402421 0.10122091208201574 0.2631224116067199 2.0353544361098797e-07 6.6913599519211715 -0.4778035880861319 WVSSLAVHPAGDNVICGSYDSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WVSSLAVHPAGDNVICGSYDSK 22 0 Q14137;Q14137-2 Q14137 BOP1 Ribosome biogenesis protein BOP1 0 7761000.0 1837000.0 2202400.0 3721600.0 False True 2516188.543058379 2105090.68563714 2842634.72875793 1.0 0.836618818349138 1.1297383642414816 21.2628085996272 -6.755414375357389 1.6295593757791513 0.9045603686508379 1.1305793143350948 0.6720307272486935 0.06868108707298372 0.290694508064014 1.5202377011489423 0.03327088963639681 0.08032686691179677 1.756247118282023e-07 6.755414375357389 0.22601894568425696 WVTTASLLDYDTVAGADK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WVTTASLLDYDTVAGADK 18 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 12619300.0 5405600.0 2480500.0 4733200.0 False True 5234002.186875839 3470976.585636611 3493432.927043686 1.0 0.663159177567793 0.667449649868967 22.31948309649848 -9.958261054394557 5.544175518768104 1.000000561133795 0.6653044137178409 0.9998767682274764 0.0017515779841363389 1.2148330551128171e-08 2.2836914935508695e-09 0.001695960920057426 0.0005653193632362357 1.1008773732742737e-10 9.958261054394557 -0.3346961474159541 WVTTASLLDYDTVAGADK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WVTTASLLDYDTVAGADK 18 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 11591700.0 1910300.0 3676300.0 6005100.0 False True 2616589.5339163975 3513868.9101016177 4586819.058916656 1.0 1.3429194241414746 1.752976154441505 21.319256194960232 -6.968750114941406 0.28647285082524665 0.9164212461564835 2.1920813837250708 0.9999709242833852 0.001659750701294269 0.07671040739039726 0.010474857074905548 0.0073027936603811275 0.037340207940998314 1.0746075439131033e-07 6.968750114941406 1.2756601375685874 WVTTASLLDYDTVAGADK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WVTTASLLDYDTVAGADK 18 0 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 0 10220300.0 5405600.0 2834300.0 1980400.0 False True 4494995.908683664 2819031.0633354974 2394492.483664977 1.0 0.627148749543809 0.5327018160437417 22.099888371932757 -13.999999999999998 0.19281698589061955 3.0185438365255073 0.46683212838252497 0.9994881043835026 0.004564477209770442 12.397940438342713 0.13925131312209266 9.41168734103626 0.06352659949030963 1.0000000000000041e-14 13.999999999999998 -2.5517117081429825 WVTTASLLDYDTVAGADK(ub)FGNICVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WVTTASLLDYDTVAGADKFGNICVVR 26 1 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 1 162469000.0 30232000.0 51116000.0 81121000.0 True False 45864154.25525194 41993950.42886908 65087398.79340261 1.0 0.9156159338544944 1.4191343948296922 25.450863700595846 -6.863805813391332 1.1662829837626356 0.9536621807123783 1.4453591699343535 0.9581049386842351 0.04506768824414791 0.1429366939567394 0.36729646125354254 0.030087746537602225 0.0705663729800503 1.368340516556614e-07 6.863805813391332 0.49169698922197524 WVTTASLLDYDTVAGADK(ub)FGNICVVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WVTTASLLDYDTVAGADKFGNICVVR 26 1 Q15393;Q15393-3 Q15393 SF3B3 Splicing factor 3B subunit 3 1 127906000.0 30232000.0 37155000.0 60519000.0 True False 39135919.96181261 35087291.58813007 49505162.97737857 1.0 0.896549554025227 1.2649546254613124 25.221990022688296 -6.831752851447022 1.3202450275430635 0.9447887075615392 1.275214595006691 0.9093003493867418 0.0467235769195463 0.17865994038393318 0.6084494415507496 0.02778307486096773 0.063929135059559 1.4731506053278978e-07 6.831752851447022 0.3304258874451519 WWHTGALYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WWHTGALYR 9 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;H0YFS2;F5H867 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 6605300.0 2397300.0 1676200.0 2531800.0 False True 3142883.5154862218 1426117.4937764243 2269833.6227404913 1.0 0.4537608494713161 0.7222137287481796 21.58365737192709 -10.111369577323758 5.319927056982453 1.0000077172314736 0.5879872891094714 0.7584938342401986 0.10959542903586648 1.0031610615208622e-05 1.6755477784874511e-06 0.10611730453835579 0.035371772622888396 7.738030241377888e-11 10.111369577323758 -0.41202042812200224 WWHTGALYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WWHTGALYR 9 0 F5GZS6;J3KPF3;P08195-2;P08195-3;P08195;P08195-4;H0YFS2;F5H867 F5GZS6 SLC3A2 4F2 cell-surface antigen heavy chain 0 4623900.0 2397300.0 1348000.0 878600.0 False True 3283646.594596545 1288440.902760108 671092.7753349944 1.0 0.3923811121697206 0.20437423943225844 21.64686743344998 -13.999999999997664 0.164272193349234 4.021034939178761 0.027997558043235844 0.9995257891110573 0.007393883183659112 12.040880352508697 0.12821360504738685 11.588261319985449 0.1616577299598651 1.0000000000053786e-14 13.999999999997664 -3.993037381135525 WWTCFVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WWTCFVK 7 0 O15145 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 0 18621500.0 6124500.0 5734500.0 6762500.0 False True 8029278.8097423725 4878934.95290592 6062781.370480512 1.0 0.6076429861902461 0.7550841755705632 22.936838979939267 -10.066560526914325 5.742307597356651 1.000001390588235 0.6813635825005564 0.8616335786921192 0.06019261350864988 1.0715888769231534e-06 1.741527083230142e-07 0.05828150185971552 0.01942708247361595 8.579055414929451e-11 10.066560526914325 -0.3186378080876786 WWTCFVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WWTCFVK 7 0 O15145 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 0 17755200.0 6785800.0 5807200.0 5162200.0 False True 10294554.708431076 4770859.788139301 4141888.9073273623 1.0 0.4634352745954172 0.402337840211313 23.295378091672525 -13.999999999999998 0.3066802444534344 6.087138234915129 0.3883203483138593 0.999664675762564 0.004916747876282757 17.036800830084474 0.17608609268428252 55.20363851778134 0.02146473616901021 1.0000000000000041e-14 13.999999999999998 -5.698817886601269 WWTCFVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WWTCFVK 7 0 O15145 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 0 18822500.0 6124500.0 6396800.0 6301200.0 False True 8388893.158389257 6114168.224611172 4812986.337287584 1.0 0.7288408743764652 0.5737331786702264 23.00004904146216 -12.783621554099922 0.07186361213184451 2.342976599722677 2.17127832070125e-14 0.9999389171607831 0.0013767703543083984 7.997366942506547 0.06172550609532504 2.0617898147640807 0.4661306423852478 1.6458052596317911e-13 12.783621554099922 -2.3429765997226553 WWTCFVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WWTCFVK 7 0 O15145 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 0 7617010.0 4293500.0 540610.0 2782900.0 False True 3570235.4843002306 537697.6266273168 3364791.523324215 1.0 0.15060564744028532 0.9424564676813516 21.76758780347433 -9.816260114687815 11.41278960136258 1.0000205662269679 0.5465310575608477 0.30423523978498357 0.32327174388389013 0.0 0.0 0.31300651999190077 0.10433550666396689 1.5266514175569342e-10 9.816260114687815 -0.45348950866612014 WWTCFVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WWTCFVK 7 0 O15145 O15145 ARPC3 Actin-related protein 2/3 complex subunit 3 0 28605800.0 6785800.0 11311000.0 10509000.0 False True 8784351.868115498 10681532.906831903 8596469.83144586 1.0 1.2159727965363718 0.9786117360175892 23.066504413764974 -6.667214514611821 1.9471474816365222 1.1381831402240852 0.9795801432042951 0.2667881435235505 0.09179983412946764 0.4675586610793859 3.4148237089881257 0.037990492864107196 0.10187486629146901 2.1517186562716623e-07 6.667214514611821 -0.15860299701979008 WYHPGCFVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WYHPGCFVK 9 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 37780500.0 11987000.0 9935500.0 15858000.0 False True 15715073.082273113 8453162.128275668 14217166.280677253 1.0 0.5379015473883471 0.9046834339392589 23.90564564555519 -9.884080860156313 6.547527542960548 1.0000000137606 0.7212924906637888 0.4349884028899179 0.14973807815757278 3.016343887478597e-08 4.949393459492536e-09 0.14498327939099312 0.04832775691644092 1.3059277182208636e-10 9.884080860156313 -0.27870752309681124 WYHPGCFVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WYHPGCFVK 9 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 9165000.0 4795300.0 1801800.0 2567900.0 False True 4643075.826314515 2521268.136262874 1895289.9546512892 1.0 0.5430167911481545 0.4081970714132604 22.146649411149415 -13.999999999999998 0.1711121740930905 3.3113658744893675 0.2906678622273788 0.9995116001118489 0.005596864215460603 12.102539333782586 0.13101340673741432 9.28613105163816 0.10881374513897069 1.0000000000000041e-14 13.999999999999998 -3.0206980122619886 WYHPGCFVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WYHPGCFVK 9 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 26444200.0 7651600.0 15375000.0 3417600.0 False True 11608036.606889565 12631211.124576703 2742109.862012706 1.0 1.0881436329275416 0.23622512185955874 23.468620638392405 -6.881371789870362 1.0721517184722344 1.0556822726354762 0.17424718628176847 0.9747738383895466 0.06075450758994441 0.1264203777133044 0.2650198485800027 0.04359684854952496 0.10580259289177296 1.3140993792004035e-07 6.881371789870362 -0.8814350863537077 down WYHPGCFVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WYHPGCFVK 9 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 33011800.0 11987000.0 8848800.0 12176000.0 False True 16418917.836494714 8457830.756931478 9300279.572591508 1.0 0.51512717471136 0.5664368178954863 23.96885570707808 -10.748427245751646 10.666560846472612 1.0009519251817038 0.5407819966325377 0.99072371609096 0.020947074114230337 0.0004749137536912338 1.1200904223446808e-05 0.020312855376667226 0.0067606390996822145 1.7847309467090968e-11 10.748427245751646 -0.46016992854916616 WYHPGCFVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WYHPGCFVK 9 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 10691900.0 4795300.0 2123400.0 3773200.0 False True 3987504.4178094575 2111960.8227381017 4562158.674694352 1.0 0.5296447605939735 1.144113760556178 21.92705468658369 -6.702149710374314 1.8230608349168267 0.7085472819168847 1.1423698259124258 0.4278373965628305 0.19846567936067724 0.3910750374094712 2.528347554455137 0.0867979405748469 0.22264276692209337 1.9854103869700534e-07 6.702149710374314 0.4338225439955411 WYHPGCFVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WYHPGCFVK 9 0 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 0 34218400.0 7651600.0 5148800.0 21418000.0 False True 9905147.035584977 4862264.753841049 17520143.767238285 1.0 0.4908826427687546 1.768791892164333 23.239746960484855 -6.798604749864923 1.4616959772119287 0.7185993350211352 1.7858129997366095 0.8280287591972308 0.21783150097572762 0.22275407583413626 0.9397493059635893 0.11724922114171639 0.27290219647384967 1.5899931384154304e-07 6.798604749864923 1.0672136647154744 WYMQFDDDEK(ub)QK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WYMQFDDDEKQK 12 1 M0R0N4;M0QYZ2;P53680;X6R390;P53680-2 M0R0N4 AP2S1 AP-2 complex subunit sigma 1 11854900.0 1440400.0 2231300.0 8183200.0 True False 1394675.290435099 3122269.7260757852 6039774.429262203 1.0 2.2387072801022567 4.330595422951793 20.41149784090691 -6.963213146069673 0.38750363936247323 0.867895934734407 5.776269990505919 0.999871431961264 0.01558516096844441 0.07857273381037107 0.017031690244903593 0.027050433464415113 0.1761553285387132 1.0883957917652239e-07 6.963213146069673 4.908374055771512 WYMQFDDDEK(ub)QK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WYMQFDDDEKQK 12 1 M0R0N4;M0QYZ2;P53680;X6R390;P53680-2 M0R0N4 AP2S1 AP-2 complex subunit sigma 1 73484800.0 4355800.0 25173000.0 43956000.0 True False 6608067.0516348975 20680681.47245332 35268077.33340084 1.0 3.1296113236830316 5.337124617201816 22.655796895090365 -6.970674158245792 0.2415457211340446 0.2223842365790832 8.308322867973054 0.9999871728805401 0.006341821531440158 0.07608458448767232 0.008243670649093704 0.05219555144542947 0.2146222763133568 1.0698572689406964e-07 6.970674158245792 8.08593863139397 WYMQFDDDEK(ub)QK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WYMQFDDDEKQK 12 1 M0R0N4;M0QYZ2;P53680;X6R390;P53680-2 M0R0N4 AP2S1 AP-2 complex subunit sigma 1 12723600.0 1440400.0 2936700.0 8346500.0 True False 1197756.4205394334 2920879.414210688 10091714.560144294 1.0 2.438625553679113 8.42551489358687 20.191903116341187 -6.943965838084368 0.6215734776546867 0.93454085132105 10.247632062154814 0.9986385754432925 0.11864119008791073 0.08600304853199225 0.046714033700214104 0.11930977127179182 0.5069746853131277 1.1377167759218212e-07 6.943965838084368 9.313091210833765 WYMQFDDDEK(ub)QK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WYMQFDDDEKQK 12 1 M0R0N4;M0QYZ2;P53680;X6R390;P53680-2 M0R0N4 AP2S1 AP-2 complex subunit sigma 1 70620800.0 4355800.0 16792000.0 49473000.0 True False 5638668.96565438 15857510.43864566 40469421.63584743 1.0 2.8122790210305175 7.177123161928848 22.426923217182814 -6.956256253381001 0.4853330358190565 0.9003125087345195 9.272719048507287 0.9996051451863868 0.0515169655461436 0.08106667255890145 0.026287067476287635 0.06222412902279249 0.36001287314421687 1.1059710185084985e-07 6.956256253381001 8.372406539772768 WYPGCKYLLEQK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WYPGCKYLLEQK 12 1 P98170 P98170 XIAP E3 ubiquitin-protein ligase XIAP 1 36659500.0 10825000.0 19739000.0 6095500.0 True False 14013175.892650858 18640507.29802446 4986181.545111642 1.0 1.3302128968352125 0.3558209490345883 23.74028062392978 -6.815252985588411 1.392191591520983 1.1788757712963103 0.33661765885586814 0.8731600905428326 0.1441033070549216 0.19970480530018286 0.7617899188418839 0.0813641112206241 0.18781808768731287 1.5301958310425978e-07 6.815252985588411 -0.8422581124404421 down WYQMGAYQPFFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 WYQMGAYQPFFR 12 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 19180400.0 6644500.0 10245000.0 2290900.0 False True 8711003.845429529 8716485.93469721 2053859.643864517 1.0 1.000629329221403 0.2357776073009234 23.054407552140614 -6.906709776585212 0.9178536454886005 1.0262153912241643 0.14358726138649927 0.9896194528198303 0.03671998643679214 0.10663409276918123 0.15086858027043704 0.029582391378320597 0.07991351611526754 1.2396247064975216e-07 6.906709776585212 -0.882628129837665 down WYQMGAYQPFFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 WYQMGAYQPFFR 12 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 28063500.0 14557000.0 6378900.0 7127600.0 False True 14094896.003098954 8926028.035524042 5260667.736583408 1.0 0.633280872278982 0.3732321072412864 23.748669497468086 -8.000449065979945 0.18783636217744426 1.2728484856852347 5.376454948304379e-15 0.9998768067735772 0.002853712019545639 0.10403630353830291 0.03249418603288898 0.08183817097883753 0.10531121807119127 9.989665217756588e-09 8.000449065979945 -1.2728484856852293 down WYQMGAYQPFFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 WYQMGAYQPFFR 12 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 46746000.0 13742000.0 17575000.0 15429000.0 False True 20847618.67477082 14438603.935898246 12379451.38722907 1.0 0.6925780906272726 0.5938064956171862 24.313379265037188 -13.999999997162012 0.15883642204028126 2.510346036258557 0.49545168113862575 0.999539476213084 0.003711828770100077 12.00214282451781 0.12590524848309922 5.5852313686556725 0.08951258617926658 1.000000006534708e-14 13.999999997162012 -2.014894355119931 WYQMGAYQPFFR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 WYQMGAYQPFFR 12 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 46346700.0 8601400.0 19134100.0 18611200.0 False True 11781570.024094926 18288692.193992704 14215617.869695721 1.0 1.552313669280904 1.2065979186664284 23.490028471210692 -10.212223486948485 4.748705401178949 0.9999310962900895 1.3794557939750756 0.6163122032817925 0.1411378641796322 0.00010297728938793649 1.708326788410279e-05 0.13668088511503124 0.04555204978989659 6.134462458902007e-11 10.212223486948485 0.3795246976849861 WYQMGAYQPFFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WYQMGAYQPFFR 12 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 7483400.0 2881100.0 3331600.0 1270700.0 False True 2395762.3043711158 3313652.0095291757 1536397.4949470267 1.0 1.3831305399051284 0.6412979668908886 21.192053347519323 -6.7663343981445765 1.5885305844262172 1.220779479028268 0.6376950153123657 0.7163386114762837 0.16132767003080134 0.27239235529545586 1.3559523027355087 0.08007889232766913 0.191265674022332 1.7126381022935454e-07 6.7663343981445765 -0.5830844637159023 WYQMGAYQPFFR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 WYQMGAYQPFFR 12 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 140859600.0 18973600.0 57136000.0 64750000.0 False True 24561699.225570474 53956331.37341942 52966164.39110468 1.0 2.196767042780454 2.156453586727548 24.54990703678866 -10.423460674053322 6.499368510987266 0.9997893841210453 2.176610314754001 0.9991203419555506 0.016457899516289096 5.023561460046963e-05 4.456298325418045e-06 0.015937985702561542 0.00531176422834521 3.771718968852663e-11 10.423460674053322 1.1768209306329553 WYSVGYMK(ub)HLDRDPEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WYSVGYMKHLDRDPEK 16 2 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 55838000.0 8804000.0 24713000.0 22321000.0 True False 13356311.65861463 20302772.06644968 17909244.566358168 1.0 1.5200882238589186 1.3408824999083457 23.67101832722744 -10.126735007316755 5.96429546862967 0.9999973381249098 1.4304853618836408 0.884978046076162 0.07316043044419669 2.5917250518597063e-06 3.7944864493902054e-07 0.07083772014039373 0.023612427392639686 7.469043566886701e-11 10.126735007316755 0.4304880237587311 WYSVGYMK(ub)HLDRDPEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WYSVGYMKHLDRDPEK 16 2 P59045;P59045-3;K7EQV0;K7EMN8;P59045-2 P59045;P59045-2 NLRP11 NACHT, LRR and PYD domains-containing protein 11 1 43240000.0 8804000.0 10363000.0 24073000.0 True False 11396951.552785054 9786289.940190883 19691961.00983882 1.0 0.8586761025407206 1.727827035030848 23.44214464931989 -6.86520903807633 1.159209012799945 0.9219834916103696 1.7742864549111557 0.9596593416075847 0.07648509057785373 0.14152744143339316 0.3584792621488716 0.05134333283758211 0.12063833812972737 1.3639264826193238e-07 6.86520903807633 0.852302963300786 WYYNAAGFNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 WYYNAAGFNK 10 0 P14927;B7Z2R2;P14927-2 P14927 UQCRB Cytochrome b-c1 complex subunit 7 0 10226000.0 3483700.0 4568200.0 2174100.0 False True 4567164.436198789 3886642.3667041343 1949144.987439806 1.0 0.8509968101649856 0.4267735516573742 22.122867302771084 -6.952620569711655 0.5292921318466259 1.006724820462997 0.2518107564487134 0.9993912181881099 0.0059917928067704015 0.08245019544895076 0.03173702870192888 0.006691738082208094 0.03507781978910458 1.1152684852772484e-07 6.952620569711655 -0.7549140640142836 down WYYNAAGFNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 WYYNAAGFNK 10 0 P14927;B7Z2R2;P14927-2 P14927 UQCRB Cytochrome b-c1 complex subunit 7 0 6995100.0 2789400.0 1130200.0 3075500.0 False True 2700852.0238403613 1581494.7539151383 2269934.2869776995 1.0 0.5855540177526644 0.8404511861223938 21.364983167956748 -10.357719716866665 5.955739139627953 1.0000429164843996 0.7130026019375288 0.628294694366655 0.10406133323102254 5.930835370797224e-05 6.395977629301386e-06 0.10077198407035598 0.03358565088232407 4.388138062052114e-11 10.357719716866665 -0.28704031454687073 WYYNAAGFNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 WYYNAAGFNK 10 0 P14927;B7Z2R2;P14927-2 P14927 UQCRB Cytochrome b-c1 complex subunit 7 0 14227500.0 3236100.0 8007400.0 2984000.0 False True 4909400.290600046 6578416.907898252 2394211.09206634 1.0 1.3399634412565313 0.48767893232305787 22.227115371742066 -6.798501455742104 1.4624169434844025 1.1879313108681557 0.4763961900345491 0.8276303227815817 0.1454385827030362 0.22290812754340986 0.9413836339306729 0.07824997516982213 0.18211742111181828 1.5903713529363584e-07 6.798501455742104 -0.7115351208336067 down WYYNAAGFNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 WYYNAAGFNK 10 0 P14927;B7Z2R2;P14927-2 P14927 UQCRB Cytochrome b-c1 complex subunit 7 0 12377000.0 3483700.0 3074600.0 5818700.0 False True 4771718.03345263 2938754.0056574405 4444442.899888151 1.0 0.6158691660016365 0.9314135639888858 22.186077364293975 -9.973124883916595 6.710470901806847 1.0000000291059299 0.7736413649952597 0.4069289816878755 0.1288204610437486 5.60952321036497e-08 8.724655033289215e-09 0.12472989086654317 0.041576625022765865 1.063837061671727e-10 9.973124883916595 -0.22635866411067018 WYYNAAGFNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 WYYNAAGFNK 10 0 P14927;B7Z2R2;P14927-2 P14927 UQCRB Cytochrome b-c1 complex subunit 7 0 7405600.0 2789400.0 2550600.0 2065600.0 False True 2319509.6913723187 2536859.4115455383 2497507.409744686 1.0 1.0937050278262155 1.0767393725641459 21.145388443391024 -10.095318407400129 4.269818479616167 0.9999883123784497 1.0852222002068928 0.9711346510388714 0.006926199796685775 4818998.857586347 0.08912958502970064 553.7499728517141 0.0023710224107233 8.029372247714107e-11 10.095318407400129 0.0852338878284431 WYYNAAGFNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 WYYNAAGFNK 10 0 P14927;B7Z2R2;P14927-2 P14927 UQCRB Cytochrome b-c1 complex subunit 7 0 15874100.0 3236100.0 4274700.0 8363300.0 False True 4189195.243067664 4036809.1872366997 6841265.21470464 1.0 0.9636240263370072 1.6330738525557282 21.998241693834515 -6.894056707735882 0.9980622993790008 0.967447648681075 1.6954484352637895 0.98337011339017 0.03963706622737102 0.11591527978739544 0.20311098564312474 0.030086607393061213 0.07618998785569084 1.2762721494769142e-07 6.894056707735882 0.7280007865827145 YAAPEQNNDPQQSK(ub)VVNLGVLAQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAAPEQNNDPQQSKVVNLGVLAQK 24 1 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 1 10623700.0 4324000.0 3746900.0 2552800.0 True False 5668805.873675562 3187877.125301804 2288660.744186715 1.0 0.5623542587876335 0.4037288972647046 22.43461343472761 -13.99999999999965 0.14119574724026163 3.0928728815261626 0.21022116734986493 0.999598209601267 0.005054351702801148 11.935421652290172 0.11781524927909935 6.877831546994717 0.1731364023090983 1.0000000000008057e-14 13.99999999999965 -2.8826517141762977 YAAPEQNNDPQQSK(ub)VVNLGVLAQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YAAPEQNNDPQQSKVVNLGVLAQK 24 1 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 1 10982600.0 4245600.0 2900700.0 3836300.0 True False 4110825.751923944 4058964.636950662 2831457.9434669297 1.0 0.9873842585156984 0.6887808227195604 21.970996790128243 -6.915773574599249 0.8554778463126563 1.0076443198125236 0.645015876190961 0.9929242592076789 0.012098507620965761 0.10072294943161664 0.11896962055832161 0.010197178815055625 0.029413584800583235 1.214021632369671e-07 6.915773574599249 -0.36262844362156255 YAAPEQNNDPQQSK(ub)VVNLGVLAQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAAPEQNNDPQQSKVVNLGVLAQK 24 1 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 1 12236700.0 4245600.0 4834100.0 3157000.0 True False 3530404.511970433 4808057.743806277 3817114.1036812468 1.0 1.3618999543830588 1.0812115412663552 21.75140206556252 -10.401070839668577 6.093338562066266 0.999950343437337 1.2215557478246482 0.4537674754357087 0.11459056480790897 7.732277083911468e-05 7.600125633754345e-06 0.11097665291858401 0.0369839457611277 3.971267671057322e-11 10.401070839668577 0.22160540438731113 YAAPEQNNDPQQSK(ub)VVNLGVLAQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YAAPEQNNDPQQSKVVNLGVLAQK 24 1 A0A0A0MTB8;Q8NI36 A0A0A0MTB8 WDR36 WD repeat-containing protein 36 1 29938700.0 8830500.0 4075200.0 17033000.0 True False 11431256.325178148 3848411.5376112964 13933168.773338772 1.0 0.33665691925172725 1.2188659213817108 23.446480632462237 -6.705532933364649 1.811277518747428 0.5903410340247678 1.216519815292504 0.44381459471830975 0.2797325229733694 0.3841172569329368 2.453647446835332 0.12303803166236067 0.31426184543403246 1.9700038124705096e-07 6.705532933364649 0.6261787812677363 YAASSYLSLTPEQWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAASSYLSLTPEQWK 15 0 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CF74;A0A5H1ZRQ7;A0M8Q6;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC6;IGLC7;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-6 chain C region;Ig lambda-7 chain C region;Ig lambda-1 chain C regions 0 660321200.0 159312800.0 288548400.0 212460000.0 False True 208860623.58734956 245498103.47285354 190476677.26022792 1.0 1.175415926928809 0.911979836067888 27.637965286401325 -6.727200655836074 1.733243830094953 1.1058924387508746 0.9122099413299737 0.5462901148919491 0.0737585782721722 0.34152952045439566 2.00866954424619 0.033739995774703865 0.08399634149055701 1.8741284098188823e-07 6.727200655836074 -0.19368249742090093 YAASSYLSLTPEQWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YAASSYLSLTPEQWK 15 0 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CF74;A0A5H1ZRQ7;A0M8Q6;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC6;IGLC7;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-6 chain C region;Ig lambda-7 chain C region;Ig lambda-1 chain C regions 0 751420000.0 316740000.0 121290000.0 313390000.0 False True 306685262.0747101 169721729.5189942 231303757.50152543 1.0 0.5534068653016954 0.7542056502381868 28.192183597883137 -10.052227179675546 4.968101455651605 1.0000063898786156 0.6538062578969029 0.7985204238342555 0.08197576068684662 6.148564829515649e-06 1.173006193197925e-06 0.07937424145222759 0.026457562993071487 8.866920616109558e-11 10.052227179675546 -0.3462001319817126 YAASSYLSLTPEQWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YAASSYLSLTPEQWK 15 0 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CF74;A0A5H1ZRQ7;A0M8Q6;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC6;IGLC7;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-6 chain C region;Ig lambda-7 chain C region;Ig lambda-1 chain C regions 0 820120400.0 177180000.0 501020000.0 141920400.0 False True 268795013.593065 411609066.51287293 113869770.73407885 1.0 1.5313121363777136 0.42363051759014003 28.001931134078358 -6.776265038269907 1.5503443354029496 1.302300123850411 0.41584969540922145 0.753983478895782 0.22435781061313553 0.2564185575125927 1.2170460298948804 0.11401043184693868 0.2698775471149647 1.6739210151678342e-07 6.776265038269907 -0.8864504284411896 down YAASSYLSLTPEQWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YAASSYLSLTPEQWK 15 0 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CF74;A0A5H1ZRQ7;A0M8Q6;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC6;IGLC7;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-6 chain C region;Ig lambda-7 chain C region;Ig lambda-1 chain C regions 0 644642800.0 159312800.0 203740000.0 281590000.0 False True 218215047.4265383 194738093.12191737 215084241.5280914 1.0 0.8924136782431359 0.9856526580757412 27.701175347924217 -10.111796326062889 4.880411385255659 1.0000028202934883 0.9390331681590826 0.363087196377055 0.03806465412248488 1.168124258142258e-06 2.125902489378951e-07 0.0368576476190003 0.01228531429111894 7.730430391718981e-11 10.111796326062889 -0.06096965213440575 YAASSYLSLTPEQWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAASSYLSLTPEQWK 15 0 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CF74;A0A5H1ZRQ7;A0M8Q6;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC6;IGLC7;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-6 chain C region;Ig lambda-7 chain C region;Ig lambda-1 chain C regions 0 595900000.0 316740000.0 150370000.0 128790000.0 False True 263383343.96116313 149559926.96389204 155719393.54232106 1.0 0.5678412488602362 0.5912271869601688 27.972588873317413 -10.392985259961588 5.877165553298704 1.000113816319535 0.5795342179102039 0.9976852544875118 0.009547269250192706 1.4241967879481904e-05 1.4709759194257708e-06 0.00924658387666947 0.003081367900645986 4.045896233142016e-11 10.392985259961588 -0.42057959840933123 YAASSYLSLTPEQWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YAASSYLSLTPEQWK 15 0 P0DOY2;P0DOY3;A0A5H1ZRQ4;A0A0B4J231;B9A064;P0CF74;A0A5H1ZRQ7;A0M8Q6;P0CG04 P0DOY2;P0CG04 IGLL5;IGLC6;IGLC7;IGLC1 Immunoglobulin lambda-like polypeptide 5;Ig lambda-6 chain C region;Ig lambda-7 chain C region;Ig lambda-1 chain C regions 0 671020000.0 177180000.0 366610000.0 127230000.0 False True 229363002.73994315 346207831.22390944 104075445.49004236 1.0 1.5094318921890273 0.4537586456698311 27.773057456170807 -6.775478514571552 1.5533993332822948 1.2901465200520066 0.4465389034529301 0.7510971647813562 0.21505859110326433 0.2576630219848995 1.227702578853953 0.10907669986520378 0.2583743156261423 1.67695529607459e-07 6.775478514571552 -0.8436076165990765 down YADLTEDQLPSCESLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YADLTEDQLPSCESLK 16 0 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 30788170.0 837170.0 15170000.0 14781000.0 False True 1097537.9771658115 12906695.13219685 13251603.909363763 1.0 11.759679756618535 12.073936560795442 20.06583943028832 -9.816162032488126 0.8786476375975039 4.746426429661869e-22 11.999734184430588 0.9998798090268504 0.05643652432452376 1.136561453879587 0.4792576995551521 3.6145610383656677 0.04328095815280947 1.5269962394352659e-10 9.816162032488126 11.999734184430588 YADLTEDQLPSCESLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YADLTEDQLPSCESLK 16 0 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 18109500.0 6380200.0 1952600.0 9776700.0 False True 6177664.04334491 2732283.3626744854 7215888.975286909 1.0 0.4422842264493044 1.1680610866271468 22.558629985097244 -6.7014005605180165 1.8256554123703508 0.6541649252669387 1.1659766212976974 0.42434730219675454 0.23535794398040855 0.3926058988139817 2.5449441725986133 0.1028046674586462 0.263951898801232 1.9888381382970856e-07 6.7014005605180165 0.5118116960307587 YADLTEDQLPSCESLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YADLTEDQLPSCESLK 16 0 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 0 39966170.0 837170.0 22517000.0 16612000.0 False True 1146694.372668581 21522124.48623838 12688587.734879276 1.0 18.76884111339293 11.06536147495907 20.129049491811212 -10.002215997792872 7.004002007032947 0.9999985709107931 14.917101294176016 0.8131447070575568 3.1449323930138546 7.01887319824468e-05 1.0054549612092338e-05 3.0450680571220556 1.0150225652575666 9.949104722758587e-11 10.002215997792872 13.917102723265222 YADLTEDQLPSCESLK(ub)DTIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YADLTEDQLPSCESLKDTIAR 21 1 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 1 22864100.0 7431700.0 5657000.0 9775400.0 True False 7195784.751406905 7915869.600865285 7214929.484286074 1.0 1.1000703709651112 1.002660548298839 22.77872060100496 -6.639912917060404 2.0448265837569646 1.065445148142692 1.003066046347211 0.15424251077761575 0.04281820201816882 0.5335973423693016 4.264113074505724 0.017053109893124252 0.04741234027891841 2.2913270541649468e-07 6.639912917060404 -0.06237910179548112 YADLTEDQLPSCESLK(ub)DTIAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YADLTEDQLPSCESLKDTIAR 21 1 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 1 50506200.0 9094200.0 14347000.0 27065000.0 True False 13796566.275076464 11786665.756377354 21715590.886989076 1.0 0.8543187863831017 1.5739851825463522 23.71780591423474 -6.854020644866639 1.2155940108822707 0.9219067167864882 1.6050546130048413 0.9459449665088385 0.07222826100436086 0.15309134290129559 0.43331349150800486 0.04644286595960923 0.10778091062260078 1.3995207925841612e-07 6.854020644866639 0.6831478962183531 YADLTEDQLPSCESLK(ub)DTIAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YADLTEDQLPSCESLKDTIAR 21 1 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 1 16554000.0 7431700.0 4017300.0 5105000.0 True False 6179787.830132526 3995658.0075283824 6172431.8971468955 1.0 0.6465688009620056 0.9988096787158673 22.559125876439236 -10.97003153089434 9.567871619952152 1.0916221848273402 0.8226892398696174 0.2525344324070724 0.1438017361745046 0.08454440443210791 0.0002648097022036285 0.04188446417550492 0.04641181077996406 1.0714415130091508e-11 10.97003153089434 -0.2689329449577228 YADLTEDQLPSCESLK(ub)DTIAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YADLTEDQLPSCESLKDTIAR 21 1 P18669 P18669 PGAM1 Phosphoglycerate mutase 1 1 42373200.0 9094200.0 12683000.0 20596000.0 True False 11772621.173482265 11977179.900746975 16847739.332806032 1.0 1.0173758013827436 1.4310950029340475 23.48893223632719 -6.915725160504129 0.85583494104653 0.9893910883602903 1.4916643998209071 0.9929086208862212 0.01677898490898995 0.10075276507178536 0.11913211231094847 0.014138587832149196 0.04076540273503708 1.214156976099438e-07 6.915725160504129 0.5022733114606168 YAEAVTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAEAVTR 7 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 28958800.0 836800.0 16037000.0 12085000.0 False True 1097052.9035827282 13644342.111736402 10834560.127505664 1.0 12.437269038874103 9.87605984371622 20.06520166835254 -9.508678161182837 9.804442601190289 0.9999994771049061 11.156664441295163 0.954478625524895 1.0456092754435822 0.0 0.0 1.0124068276082265 0.33746894253607546 3.099715527391499e-10 9.508678161182837 10.156664964190258 YAEAVTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YAEAVTR 7 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 11736500.0 0.0 2794500.0 8942000.0 False True 0.0 3910358.4231249797 6599821.945750157 0.0 YAEAVTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YAEAVTR 7 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 24431800.0 836800.0 11477000.0 12118000.0 False True 1146187.5736697088 10969908.190636324 9255977.978044005 1.0 9.570779201099128 8.075447850485295 20.12841172987543 -9.890559818780941 9.921158104726635 0.9999999999244663 8.823113525532392 0.9733291650106537 0.6104664675651168 0.0 0.0 0.591081646401752 0.19702720519148054 1.2865900287018362e-10 9.890559818780941 7.823113525607925 YAFK(ub)CHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAFKCHR 7 1 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 2517490.0 328490.0 1298300.0 890700.0 True False 430653.5711016856 1104598.7007337625 798538.9081977078 1.0 2.5649356579303633 1.8542488946623816 18.716168268989563 -10.085286253546947 4.545691371020391 0.9999169117409206 2.209592276347837 0.7943413885760309 0.2901366563238812 50416492.30851052 7.71552967177443 44362.99129715649 0.09932149461777379 8.217008693512407e-11 10.085286253546947 1.2096753646069163 YAFK(ub)CHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YAFKCHR 7 1 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 1853340.0 328490.0 503150.0 1021700.0 True False 449941.63010846416 480919.16930545156 780395.5025720063 1.0 1.0688479063151366 1.7344372032965298 18.779378330512454 -6.926753104751348 0.772974287170647 0.9885673575343935 1.8604299018739678 0.9958608344807055 0.02130718490051107 0.09435902178830935 0.08619751610910927 0.019049330790216343 0.06133458783470434 1.1837143028873124e-07 6.926753104751348 0.8718625443395743 YAFK(ub)CHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAFKCHR 7 1 O43684-2;O43684;J3QT28 O43684-2 BUB3 Mitotic checkpoint protein BUB3 1 1974790.0 713450.0 610180.0 651160.0 True False 593265.2861940135 606892.8392287529 787314.5453763317 1.0 1.0229704204036012 1.3270868255704056 19.17831784310876 -6.922023015302149 0.8095650397571004 0.9937667534597167 1.3784881569442407 0.9947250753328225 0.01082684828058077 0.0969957985459904 0.0995476812301029 0.009429839942219884 0.028817785855911417 1.1966771120922703e-07 6.922023015302149 0.384721403484524 YAFSGVAFTGAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YAFSGVAFTGAK 12 0 P23919;H7BZ20;P23919-2 P23919;P23919-2 DTYMK Thymidylate kinase 0 24976900.0 5121100.0 10006000.0 9849800.0 False True 7769083.102559222 8220351.122765165 7902982.712679288 1.0 1.058085106601227 1.01723493086024 22.889312912944863 -10.521481915476512 6.16322482163562 0.9999576724042601 1.037660018730296 0.531223753846645 0.01667701441140645 9.711410102688649e-06 7.540036034283526e-07 0.01616559556837737 0.0053824832566531635 3.009664492167081e-11 10.521481915476512 0.03770234632603586 YAFVNWINK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAFVNWINK 9 0 P13796;Q5TBN3;P13797;A0A0A0MSQ0;P13797-2;P13797-3;U3KQI3 P13796;P13797 LCP1;PLS3 Plastin-2;Plastin-3 0 390760000.0 101780000.0 106960000.0 182020000.0 False True 133434565.63892211 91001984.9268145 163186316.45912957 1.0 0.6819970859205146 1.222968843775582 26.99155719785752 -6.747378851708416 1.6595011531067716 0.8124316577330675 1.2238385927698254 0.6377141489346565 0.1336124826274264 0.3045983593650176 1.6495875483682407 0.06362487508349852 0.1548941780372724 1.7890445210795985e-07 6.747378851708416 0.41140693503675796 YAFVNWINK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YAFVNWINK 9 0 P13796;Q5TBN3;P13797;A0A0A0MSQ0;P13797-2;P13797-3;U3KQI3 P13796;P13797 LCP1;PLS3 Plastin-2;Plastin-3 0 359280000.0 114350000.0 43910000.0 201020000.0 False True 110720021.84202538 61443491.987624966 148366831.52926582 1.0 0.554944724227856 1.3400180840006937 26.722340891790388 -6.752902041052284 1.6389093699085313 0.7392173191993141 1.341948764345092 0.6614201746872108 0.1870496872057139 0.29502035266428167 1.559921736029642 0.0901216650941388 0.21814538511207873 1.7664362110087808e-07 6.752902041052284 0.6027314451457779 YAFVNWINK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YAFVNWINK 9 0 P13796;Q5TBN3;P13797;A0A0A0MSQ0;P13797-2;P13797-3;U3KQI3 P13796;P13797 LCP1;PLS3 Plastin-2;Plastin-3 0 87263000.0 24726000.0 35113000.0 27424000.0 False True 37511149.71273345 28846810.810878787 22003634.379633803 1.0 0.7690196390084657 0.5865891754356038 25.160816146337538 -6.973781978911968 0.1411186784327641 1.2404587089637242 0.11038736251067661 0.9999988854506566 0.00017849447532319925 0.07509356978872467 0.004277886598325617 0.01019199200502116 0.02363883990369265 1.0622286750272691e-07 6.973781978911968 -1.1300713464530476 YAFVNWINK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YAFVNWINK 9 0 P13796;Q5TBN3;P13797;A0A0A0MSQ0;P13797-2;P13797-3;U3KQI3 P13796;P13797 LCP1;PLS3 Plastin-2;Plastin-3 0 342309000.0 101780000.0 99389000.0 141140000.0 False True 139410816.50107902 94997665.34452842 107805638.86954391 1.0 0.6814224873562315 0.7732946522747717 27.054767259380412 -10.200333546159042 7.629074554276243 1.0000002162105377 0.7273585698155018 0.9215214582639875 0.037506654269208135 1.3793476356468146e-07 1.4470151209476266e-08 0.03631569051935157 0.0121052206130502 6.304729436595991e-11 10.200333546159042 -0.27264164639503585 YAFVNWINK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAFVNWINK 9 0 P13796;Q5TBN3;P13797;A0A0A0MSQ0;P13797-2;P13797-3;U3KQI3 P13796;P13797 LCP1;PLS3 Plastin-2;Plastin-3 0 259401000.0 114350000.0 63461000.0 81590000.0 False True 95087091.56392948 63119122.9969777 98650091.77046336 1.0 0.6638032771729179 1.0374709137479337 26.502746167224664 -6.669667277999452 1.9388451386359529 0.7853386878507779 1.0359474597238236 0.27740874943900096 0.1428213315124746 0.46190653789847086 3.347315395113202 0.05931362066890245 0.15852300915749584 2.1396006541435368e-07 6.669667277999452 0.25060877187304575 YAFVNWINK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YAFVNWINK 9 0 P13796;Q5TBN3;P13797;A0A0A0MSQ0;P13797-2;P13797-3;U3KQI3 P13796;P13797 LCP1;PLS3 Plastin-2;Plastin-3 0 104440000.0 24726000.0 49904000.0 29810000.0 False True 32008294.42232658 47126798.53085837 24384885.876429826 1.0 1.4723308249122533 0.7618302167147264 24.931942468429988 -6.727483423399185 1.7321114358150507 1.2850469522690582 0.7624249103511141 0.5475831019806727 0.1986009236547605 0.34103098492242584 2.0032322952800645 0.090899546421012 0.2262319137885396 1.8729085687639747e-07 6.727483423399185 -0.522622041917944 YAGK(ub)DGYNYTLSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAGKDGYNYTLSK 13 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 48242500.0 14557200.0 18406900.0 15278400.0 True False 19084630.172125313 15660662.269534245 13697537.728761474 1.0 0.82059029325116 0.717726128576904 24.185907894044526 -13.99999987307215 0.0630572093254437 2.105811640991812 0.2844377600519112 0.9999459868403263 0.0008572223840935168 12.432365647429068 0.06537461280680235 2.1203463268324194 0.4038495939559119 1.000000292262217e-14 13.99999987307215 -1.821373880939901 YAGK(ub)DGYNYTLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YAGKDGYNYTLSK 13 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 66902500.0 19061500.0 21659400.0 26181600.0 True False 18456403.116237573 30308111.37227887 19323853.528836057 1.0 1.6421461528229409 1.0469999710742837 24.137618084368345 -10.253563377642628 4.674427173210545 0.9998882842000942 1.3445730619497964 0.30888872473707174 0.2429674112790985 0.0002829669778258191 4.518598843033856e-05 0.23532811035452172 0.07841739479567446 5.577462029515207e-11 10.253563377642628 0.3446847777497022 YAGK(ub)DGYNYTLSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YAGKDGYNYTLSK 13 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 129093700.0 27094900.0 35883800.0 66115000.0 True False 41104944.20252134 29480055.528590936 53047341.27076601 1.0 0.717190014499099 1.2905343213557297 25.292808599419118 -6.772585466832461 1.5645044736518519 0.8383201256441324 1.2940815322935795 0.7403339458191418 0.11927807062941816 0.2622889592409705 1.2673401273090277 0.060080620291401376 0.14268338828999913 1.6881636052216842e-07 6.772585466832461 0.4557614066494471 YAGK(ub)DGYNYTLSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YAGKDGYNYTLSK 13 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 43157800.0 14557200.0 12612800.0 15987800.0 True False 19939390.233538073 12055524.791047998 12211810.919076748 1.0 0.6046084985472923 0.6124465580966699 24.249117955567417 -10.036769231088934 4.908313235875492 1.000007213027002 0.6085275283177359 0.9996994291998376 0.0031998744283404483 3346413.7289791573 0.194989062754974 277.07109485342204 0.0011710341303005206 9.188206960018322e-11 10.036769231088934 -0.391479684709266 YAGK(ub)DGYNYTLSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAGKDGYNYTLSK 13 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 62890300.0 19061500.0 30392800.0 13436000.0 True False 15850481.817628697 30229067.95390151 16245405.478955097 1.0 1.9071387420085326 1.024915561928671 23.91802335980262 -6.639745536729476 2.046082497864459 1.5933491103291466 1.0286300017598664 0.15343683593919 0.38816635609033634 0.5339586603561879 4.2722814084102625 0.15453552543161933 0.4296466761039818 2.2922103188906046e-07 6.639745536729476 -0.5647191085692802 YAGK(ub)DGYNYTLSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YAGKDGYNYTLSK 13 1 P31949 P31949 S100A11 Protein S100-A11;Protein S100-A11, N-terminally processed 1 121154900.0 27094900.0 29950400.0 64109600.0 True False 35074882.17032667 28283633.911482483 52442310.62004572 1.0 0.8063785866516872 1.4951528665265734 25.063934921511567 -6.8316605559499575 1.3206072260148676 0.8966580285986854 1.5143061822261135 0.9091310920284691 0.0874291044279807 0.17877154138898363 0.6091892096769975 0.05197325986057761 0.11959417987280899 1.473463709964494e-07 6.8316605559499575 0.6176481536274281 YAHEK(ub)LNASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YAHEKLNASR 10 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 8181400.0 1198600.0 1203800.0 5779000.0 True False 1160551.0990804692 1684483.617734069 4265306.533716182 1.0 1.4514514863401735 3.675242337106639 20.14637861528706 -6.940138941967575 0.6582687724187972 0.9750970398030753 4.277388803729023 0.9981820534764029 0.049857135389595054 0.08770328459431463 0.05432125110328411 0.04858343946618818 0.19128032934068123 1.1477863563939003e-07 6.940138941967575 3.3022917639259477 up YAHEK(ub)LNASR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YAHEKLNASR 10 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 14660600.0 1183200.0 5872800.0 7604600.0 True False 1795000.9035066843 4824752.955604166 6101547.476785409 1.0 2.6878833019964543 3.3991890838971313 20.77555313954759 -9.36567101026218 0.26895475233809996 6.885039968531259e-18 3.780775653443449 0.9989401775705415 0.03275507920310201 0.7681668809419516 0.10376937094844647 0.9721747286991156 0.2823270865498955 4.308528695250988e-10 9.36567101026218 3.780775653443449 YAHEK(ub)LNASR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAHEKLNASR 10 1 P49588;P49588-2 P49588 AARS Alanine--tRNA ligase, cytoplasmic 1 6147800.0 1198600.0 1620800.0 3328400.0 True False 996689.0069831735 1612068.4286963907 4024353.051217189 1.0 1.617423707296499 4.0377219202991865 19.926783890721335 -6.945339022601563 0.6078664920420799 0.9731422409497068 4.807584174899444 0.9987828726579641 0.045734835946542186 0.08541311894517827 0.04413680624859122 0.04658278309286713 0.20393392824796272 1.1341251397451554e-07 6.945339022601563 3.834441933949737 YAHQSGFHVDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAHQSGFHVDR 11 0 A0A0A0MSX9;P41252;Q5TCD1 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 6893870.0 985970.0 3229600.0 2678300.0 False True 1292616.2181470613 2747756.268882197 2401175.208067722 1.0 2.1257324721030106 1.8576087583906051 20.301862567316437 -10.121342040327603 4.511469264539469 0.9999149140954605 1.9916706150192736 0.9480224894790971 0.10946104864522202 38177676.74418059 9.364378430453192 42723.07893791855 0.037471428303571766 7.562370655322199e-11 10.121342040327603 0.991755700923813 YAHQSGFHVDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YAHQSGFHVDR 11 0 A0A0A0MSX9;P41252;Q5TCD1 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 3990950.0 1027400.0 648150.0 2315400.0 False True 994785.7493703277 906959.6750575991 1708927.2794889167 1.0 0.9117135781565828 1.7178847611866386 19.92402631506359 -6.879749690906999 1.0811524726242652 0.9454556042695952 1.7747536165096471 0.9734847799434032 0.05878782592835334 0.12785397774463736 0.2736047818745471 0.04189456790989354 0.10125121988990553 1.3190167453524718e-07 6.879749690906999 0.829298012240052 YAHQSGFHVDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YAHQSGFHVDR 11 0 A0A0A0MSX9;P41252;Q5TCD1 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 5946670.0 985970.0 2591100.0 2369600.0 False True 1350509.753837382 2476616.6343781296 1809949.2834438903 1.0 1.8338383912748437 1.340197120606528 20.36507262883933 -10.479005115808807 5.357926520559837 0.9990511472044526 1.5870177559406837 0.6534353111127638 0.20152820485276152 0.0022875715490323066 0.00022243876544381303 0.19541724605123229 0.06504294843215003 3.318905479966308e-11 10.479005115808807 0.5879666087362311 YAHVVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAHVVLR 7 0 P62269 P62269 RPS18 40S ribosomal protein S18 0 121706000.0 38782000.0 37194000.0 45730000.0 False True 50843577.56542227 31644800.18107643 40998298.27313478 1.0 0.6223952305550868 0.806361397767118 25.599562212144935 -10.156735614942793 4.992801997923875 1.0000156615826716 0.7143783141641121 0.7626954831304552 0.0751038732778362 1.471536626000317e-05 2.485430936967648e-06 0.07272349098273524 0.024239670868519383 6.970507279119273e-11 10.156735614942793 -0.2856373474185595 YAHVVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YAHVVLR 7 0 P62269 P62269 RPS18 40S ribosomal protein S18 0 80558000.0 21629000.0 16970000.0 41959000.0 False True 20942399.234116018 23746209.497380923 30968679.156981762 1.0 1.1338819985198918 1.4787550753274021 24.319923396111616 -6.954817316262762 0.5031899303758538 0.9932801656403297 1.6343124444262371 0.9995270937685293 0.004385780775316239 0.08160714325000894 0.028388973149176367 0.005113051737916415 0.028452436372925206 1.1096414820799137e-07 6.954817316262762 0.6410322787859074 YAHVVLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YAHVVLR 7 0 P62269 P62269 RPS18 40S ribosomal protein S18 0 127597000.0 45076000.0 51906000.0 30615000.0 False True 68383587.49701427 42642968.75657091 24563931.830968797 1.0 0.6235848442205927 0.35920800194990204 26.027146774733474 -8.055246113590986 0.1930017693235551 1.2697301042841995 1.0134550805446078e-13 0.9998502482692999 0.0032175716820952473 0.0969029634908288 0.035230713172427035 0.0870790377049455 0.10770913880337046 8.805497262727829e-09 8.055246113590986 -1.2697301042840983 down YAHVVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YAHVVLR 7 0 P62269 P62269 RPS18 40S ribosomal protein S18 0 106977000.0 38782000.0 28601000.0 39594000.0 False True 53120753.44414274 27337313.24914084 30242712.664026603 1.0 0.5146258566886939 0.5693201000213084 25.662772273667827 -10.295273045347708 6.771553475644753 1.000007740952065 0.5419729783568201 0.9894186176659123 0.022328831338754462 2.6095000584444574e-06 2.7157017261851244e-07 0.021620162993684508 0.007206599326272522 5.066720582515511e-11 10.295273045347708 -0.4580347625952448 YAHVVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAHVVLR 7 0 P62269 P62269 RPS18 40S ribosomal protein S18 0 59481000.0 21629000.0 24017000.0 13835000.0 False True 17985471.827164236 23887615.653998755 16727834.534187526 1.0 1.3281617454105517 0.9300748234429276 24.100328671545892 -6.687749136353372 1.8743781874196193 1.2061760016302756 0.9314886747535062 0.35980796333633946 0.13885479293155245 0.421593257784995 2.86994915336971 0.05930170168687476 0.15486735677778748 2.052347343934867e-07 6.687749136353372 -0.27468732687676944 YAHVVLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YAHVVLR 7 0 P62269 P62269 RPS18 40S ribosomal protein S18 0 121864000.0 45076000.0 47221000.0 29567000.0 False True 58351770.580797315 44593109.83940498 24186109.383039277 1.0 0.7642117693354089 0.41448801197128643 25.798273096825923 -6.965443622452996 0.3503554977715061 1.0336586536957084 0.13323375964923084 0.9999219994184392 0.0021243748213448594 0.07781074117124977 0.014330967623767637 0.004796178381295322 0.03005264254026015 1.0828202713422522e-07 6.965443622452996 -0.9004248940464776 down YAHWVVSQPPDTYLKPLMTELLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAHWVVSQPPDTYLKPLMTELLK 23 1 Q92973-2;Q92973;Q92973-3 Q92973-2 TNPO1 Transportin-1 0 33881200.0 18383000.0 11393000.0 4105200.0 False True 15286279.00498221 11331623.64766656 4963578.339699788 1.0 0.7412937866679836 0.32470808220117037 23.865733931971146 -6.964051738073376 0.373972368938854 1.0306272508346987 0.02078298716250627 0.9998922400090474 0.0028877835092112835 0.07828426588289626 0.01600383073682004 0.005460000017934362 0.0353065872587887 1.0862962040113658e-07 6.964051738073376 -1.0098442636721925 down YAICSALAASALPALVMSK ddPTM_RPMI8226_Bortezomib_1h_R1 2 YAICSALAASALPALVMSK 19 0 P36578;H3BM89;H3BTP7 P36578 RPL4 60S ribosomal protein L4 0 53754050.0 24408300.0 21613500.0 7732250.0 False True 31999517.670313448 18388850.04876313 6932190.942979367 1.0 0.5746602257640531 0.21663423225314707 24.931546823702575 -7.831148048335033 0.3156441620070883 1.0987748772039965 1.5799328174761128e-10 0.9992155000468311 0.008968485999996854 0.1150972652289971 0.052497304627591376 0.04246022981472489 0.08318547653951766 1.4752035596715023e-08 7.831148048335033 -1.0987748770460033 down YAICSALAASALPALVMSK ddPTM_RPMI8226_Bortezomib_2h_R1 2 YAICSALAASALPALVMSK 19 0 P36578;H3BM89;H3BTP7 P36578 RPL4 60S ribosomal protein L4 0 149918900.0 89779000.0 38603100.0 21536800.0 False True 86929014.78753993 54017519.142507024 15895665.989849254 1.0 0.6213980369446185 0.18285800234477842 26.373334458092177 -7.531427892574921 0.4043228165722744 1.037654667430868 7.997156312768529e-25 0.9987658254757075 0.011730033079531133 0.11989102158932581 0.05139961758094381 0.020633968892994906 0.0682213051484258 2.9415220443525496e-08 7.531427892574921 -1.037654667430868 down YAICSALAASALPALVMSK ddPTM_RPMI8226_Bortezomib_8h_R1 2 YAICSALAASALPALVMSK 19 0 P36578;H3BM89;H3BTP7 P36578 RPL4 60S ribosomal protein L4 0 377553000.0 77936000.0 193589000.0 106028000.0 False True 118234609.88480133 159041530.43223947 85071519.32627662 1.0 1.3451351561712535 0.7195145263232461 26.817077165176332 -6.756894450152873 1.6237961830832408 1.201235884617488 0.7175422280656917 0.6783598355660209 0.14510826098241303 0.2881378705958561 1.4965645734292035 0.07052868952042539 0.17003993289478986 1.7502720186807106e-07 6.756894450152873 -0.4836936565517963 YAICSALAASALPALVMSK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 YAICSALAASALPALVMSK 19 0 P36578;H3BM89;H3BTP7 P36578 RPL4 60S ribosomal protein L4 0 109514500.0 24408300.0 23161200.0 61945000.0 False True 33432708.11950567 22137861.600153882 47314866.797321 1.0 0.6621617824383772 1.4152268678981483 24.994756885225467 -6.784713594200984 1.5170891000297682 0.8098788254862622 1.4221430233762085 0.7838436189444761 0.14318712815295384 0.243319992922189 1.1062907213160624 0.07431036173112851 0.17469422050816497 1.6416720558750467e-07 6.784713594200984 0.6122641978899462 YAICSALAASALPALVMSK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 YAICSALAASALPALVMSK 19 0 P36578;H3BM89;H3BTP7 P36578 RPL4 60S ribosomal protein L4 0 139761600.0 89779000.0 11148500.0 38834100.0 False True 74655216.38406664 11088440.81769601 46954130.76140885 1.0 0.14852868097858157 0.6289464157447687 26.153739733526454 -10.063227875809838 5.581304183016282 1.0000036125805147 0.3887375485137943 0.6833960382844543 0.19612971892757894 8.816778442509381e-06 1.479462207809863e-06 0.18990290394125903 0.06330059459179398 8.645141861787485e-11 10.063227875809838 -0.6112660640667205 YAICSALAASALPALVMSK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 YAICSALAASALPALVMSK 19 0 P36578;H3BM89;H3BTP7 P36578 RPL4 60S ribosomal protein L4 0 232135000.0 77936000.0 94233000.0 59966000.0 False True 100889688.34823455 88988850.7125356 49052803.30311941 1.0 0.8820410903181545 0.48620234739755525 26.588203487268782 -6.948908276792257 0.5707049174642034 1.0049153863947466 0.34405940525566725 0.9991127887659307 0.00654534101134794 0.08392714778485884 0.037799896861602664 0.006928825899876535 0.03298685726065988 1.1248425161730512e-07 6.948908276792257 -0.6608559811390794 down YAICSALAASALPALVMSK(ub)GHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YAICSALAASALPALVMSKGHR 22 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 17520500.0 7152000.0 4083000.0 6285500.0 True False 6924963.674806873 5713363.1925637135 4639138.989041892 1.0 0.8250387237912913 0.6699152814214971 22.72337507278731 -6.972545063847209 0.1876914810712087 1.108358843595637 0.3823675424690299 0.9999960269546343 0.0002687030588983515 0.07548524106450175 0.005971550345060097 0.00558590856751243 0.017019838898011085 1.0652583231680627e-07 6.972545063847209 -0.7259913011266073 YAICSALAASALPALVMSK(ub)GHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YAICSALAASALPALVMSKGHR 22 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 94931600.0 8239400.0 20291200.0 66401000.0 True False 12499772.180825703 16670076.824130801 53276813.24540787 1.0 1.3336304520575366 4.262222740917871 23.575398464971848 -6.928411806416529 0.7597176183583852 0.9527421972064518 4.839829076234822 0.9962167664684903 0.09014194248299588 0.09347089106715102 0.08178254118185765 0.0813608496545389 0.26733862492272337 1.1792019632832435e-07 6.928411806416529 3.88708687902837 up YAICSALAASALPALVMSK(ub)GHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YAICSALAASALPALVMSKGHR 22 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 47684500.0 1384800.0 4017800.0 42281900.0 True False 1896797.98281287 3840280.3109121365 32295786.043064773 1.0 2.024612186278881 17.026476375291956 20.855134602995125 -6.920722797395714 0.8193441894014045 0.6775369874888633 19.486376194821798 0.994379404845314 0.549190034904667 0.09774851574189909 0.10342303562056573 0.47500255044662437 1.4328489453896402 1.2002651670573354e-07 6.920722797395714 18.808839207332934 up YAICSALAASALPALVMSK(ub)GHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAICSALAASALPALVMSKGHR 22 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 54827200.0 7152000.0 3344300.0 44330900.0 True False 5947204.887321591 3326283.5921084215 53600286.22707732 1.0 0.5593020007095234 9.01268532741218 22.503780348221586 -6.894603310408701 0.9947336843278369 0.5946335183695265 9.808924835125222 0.9836854451617358 0.49625788264558923 0.11548831045430982 0.2006570339686539 0.3776306275898386 0.9584770494928292 1.2746668448431568e-07 6.894603310408701 9.214291316755695 up YAICSALAASALPALVMSK(ub)GHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YAICSALAASALPALVMSKGHR 22 1 P36578;H3BM89 P36578 RPL4 60S ribosomal protein L4 1 187956300.0 8239400.0 31691900.0 148025000.0 True False 10666065.722855208 29928217.90558093 121085968.86476082 1.0 2.8059285104019986 11.35244916082771 23.346524787064297 -6.941039384815349 0.6498253886332437 0.9055226709293023 13.729369554572607 0.9982968503437525 0.18633595864210822 0.08729574613793696 0.052474913996042996 0.18284508789743448 0.7322793683279409 1.1454090631511655e-07 6.941039384815349 12.823846883643304 YAIHCIHAIFSSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAIHCIHAIFSSK 13 0 Q9NTI5;Q9NTI5-2 Q9NTI5 PDS5B Sister chromatid cohesion protein PDS5 homolog B 0 11230300.0 2444300.0 4030200.0 4755800.0 False True 3204500.9706348707 3428909.86959656 4263715.436854894 1.0 1.0700292810075915 1.3305395991220978 21.61166827616967 -6.946544030965427 0.5955855356487427 0.997034899192684 1.4167687059332115 0.9989013457101552 0.004713850911950612 0.08490404147247493 0.041940800284043324 0.004859325206852616 0.02186167756816752 1.1309827187874535e-07 6.946544030965427 0.4197338067405275 YAIHCIHAIFSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YAIHCIHAIFSSK 13 0 Q9NTI5;Q9NTI5-2 Q9NTI5 PDS5B Sister chromatid cohesion protein PDS5 homolog B 0 10083400.0 2444300.0 1975400.0 5663700.0 False True 3348023.764723789 1888120.296225753 4326050.707562949 1.0 0.5639506852131088 1.292120669256912 21.67487833769256 -6.744534588817071 1.670112127938504 0.7419206537674314 1.2929812539755947 0.6250870197007307 0.1832027621702995 0.30968661096112515 1.6977107808007441 0.08672120512260964 0.21175459339921066 1.8007997063886248e-07 6.744534588817071 0.5510606002081633 YAINLDVQK(ub)EAINLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YAINLDVQKEAINLLK 16 1 Q6SJ93;Q6SJ93-2 Q6SJ93 FAM111B Protein FAM111B 1 29658900.0 11523000.0 9063200.0 9072700.0 True False 11157208.672371311 12682183.023963638 6696287.694834201 1.0 1.1366806336936794 0.6001758944794385 23.411472800856213 -6.839139716305003 1.2863234907745238 1.0727221375191547 0.5828213766391974 0.9229765264732602 0.0631770635430648 0.16980408329628274 0.5461349643606743 0.03851694678752374 0.08871918569780585 1.448305846025824e-07 6.839139716305003 -0.48990076087995726 YAINLDVQK(ub)EAINLLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YAINLDVQKEAINLLK 16 1 Q6SJ93;Q6SJ93-2 Q6SJ93 FAM111B Protein FAM111B 1 49956000.0 22271000.0 16132000.0 11553000.0 True False 33786735.228192456 13253118.560108708 9269544.486140223 1.0 0.3922580406363143 0.2743545484206919 25.00995361555216 -13.999999999999998 0.23056920461312394 4.8466290326365655 0.21733844897021107 0.9995105765094014 0.0070339137048933895 13.309089186351596 0.15203456149707453 23.444761946932907 0.06098657118061835 1.0000000000000041e-14 13.999999999999998 -4.6292905836663545 YAINLDVQK(ub)EAINLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAINLDVQKEAINLLK 16 1 Q6SJ93;Q6SJ93-2 Q6SJ93 FAM111B Protein FAM111B 1 31382700.0 11523000.0 15375000.0 4484700.0 True False 9581885.055453958 15292171.823301444 5422430.035090051 1.0 1.5959460726986305 0.5659043083598286 23.19187807629049 -6.749841290816121 1.650536762008414 1.3504870304955137 0.563893455819138 0.6482685845233263 0.2504174467052935 0.300310234060323 1.6096345562593817 0.11985692026111987 0.2910167578853151 1.7789293857145322e-07 6.749841290816121 -0.7865935746763757 YAINLDVQK(ub)EAINLLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YAINLDVQKEAINLLK 16 1 Q6SJ93;Q6SJ93-2 Q6SJ93 FAM111B Protein FAM111B 1 47875600.0 22271000.0 17168000.0 8436600.0 True False 28830248.527041785 16212585.708115097 6901225.366826151 1.0 0.5623463735634553 0.23937446672903417 24.78107993764461 -8.037080806915187 0.27388599253828494 1.153430333990085 8.295587568141176e-22 0.9994100769445108 0.007570630700966204 0.09633379823687205 0.05299841357515636 0.06684078190242382 0.09424071482365956 9.181617430096273e-09 8.037080806915187 -1.153430333990085 down YAIQLITAASLVCR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YAIQLITAASLVCR 14 0 Q9Y230;Q9Y230-2 Q9Y230 RUVBL2 RuvB-like 2 0 109034000.0 0.0 64232000.0 44802000.0 False True 0.0 52769297.75309341 35946865.062585846 0.0 YAIQLITAASLVCR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YAIQLITAASLVCR 14 0 Q9Y230;Q9Y230-2 Q9Y230 RUVBL2 RuvB-like 2 0 106657000.0 0.0 89763000.0 16894000.0 False True 0.0 84767610.14198138 13819465.34707832 0.0 YAISMAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAISMAR 7 0 P13796;P13796-2 P13796 LCP1 Plastin-2 0 44271000.0 11937000.0 15476000.0 16858000.0 False True 15649522.598072438 13167041.124975532 15113695.873354625 1.0 0.8413701467543377 0.9657608261619552 23.899615311407853 -10.298249243472512 5.328430632075979 1.0000175792803814 0.9035654865222916 0.4448640958805511 0.050782282217820635 1.0607031320171532e-05 1.396941616533691e-06 0.04917869405123192 0.016389911109332148 5.032117305234565e-11 10.298249243472512 -0.09645209275808975 YAISMAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YAISMAR 7 0 P13796;P13796-2 P13796 LCP1 Plastin-2 0 33795900.0 11937000.0 9787900.0 12071000.0 False True 16350431.485295534 9355438.213743065 9220078.41004862 1.0 0.5721829556704182 0.5639042870728233 23.962825372930745 YAK(ub)LFADAVQELLPQYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YAKLFADAVQELLPQYK 17 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 66734200.0 5130600.0 5622600.0 55981000.0 True False 7783495.297102255 4619203.100425691 44916330.81265606 1.0 0.5934612823811162 5.770714710828966 22.891986734225544 -6.887920657933425 1.034642093689108 0.7077937770096628 6.198219848043814 0.9795322849847563 0.3362931735429286 0.1208449196757094 0.2318512444100107 0.2483160128126858 0.6145771557608926 1.294432302094191e-07 6.887920657933425 5.490426071034151 up YAK(ub)LFADAVQELLPQYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAKLFADAVQELLPQYK 17 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 19108000.0 4904500.0 7009800.0 7193700.0 True False 4078309.056189698 6972036.816063641 8697869.410089245 1.0 1.7095410671445062 2.1327146349755877 21.95953967693409 -9.069006247473334 0.14360884054755374 1.8423022014592447e-17 2.897376175096883 0.9998554988193531 0.005617694553671325 0.5367535702781335 0.04844143969306851 0.5693019072833183 0.3421834664700958 8.530878419715444e-10 9.069006247473334 2.897376175096883 YAK(ub)LFADAVQELLPQYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YAKLFADAVQELLPQYK 17 1 P33993;P33993-2 P33993 MCM7 DNA replication licensing factor MCM7 1 51570700.0 5130600.0 4194100.0 42246000.0 True False 6641662.839245686 3960694.6480897935 34557661.48056533 1.0 0.5963408176467478 5.203164074569337 22.663113056317993 -6.885549782988728 1.048319820079125 0.7254250774100733 5.566540859247625 0.9778948170045696 0.30970583384667 0.122829464056593 0.24351968535661955 0.22630990499657475 0.5558875821901544 1.301518114569138e-07 6.885549782988728 4.841115781837551 up YAK(ub)QHVPEQHPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAKQHVPEQHPK 12 1 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 1 9677900.0 3226600.0 3766100.0 2685200.0 True False 4230103.846438846 3204212.560142823 2407361.2622571955 1.0 0.7574784630501024 0.5691021661995027 22.012261650377045 -6.973950454519551 0.13350622211688187 1.277154653019071 0.044537474180965556 0.9999991243266402 0.000164946753730195 0.07504042519712026 0.004019991945609927 0.011407965984375209 0.0252922797004925 1.0618166851874027e-07 6.973950454519551 -1.2326171788381053 YAK(ub)QHVPEQHPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YAKQHVPEQHPK 12 1 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 1 10758900.0 2928000.0 4465200.0 3365700.0 True False 2835052.2427061656 6248177.645710392 2484122.201164315 1.0 2.203902119188558 0.8762174339309972 21.434943889888032 -6.66792638916652 1.9444585778043222 1.7697906505749867 0.88159548038292 0.27003817732290447 0.5116329628581779 0.4658756764468268 3.3937874767221006 0.21196710961024604 0.5679135273552752 2.1481945519570338e-07 6.66792638916652 -0.8881951701920667 YAK(ub)QHVPEQHPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YAKQHVPEQHPK 12 1 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 1 8108700.0 2779300.0 1677800.0 3651600.0 True False 4216401.294046763 1378383.4812887658 2929859.65944686 1.0 0.3269099369727777 0.6948721089673315 22.007580750668353 -10.697611264303767 6.900574202161525 1.004006357731875 0.5108910229704643 0.7020109863941109 0.15021992767214654 0.009297135389303773 0.0004074070852306117 0.14604878731440352 0.048483273178558856 2.0062670275318523e-11 10.697611264303767 -0.4931153347614107 YAK(ub)QHVPEQHPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAKQHVPEQHPK 12 1 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 1 10697500.0 2928000.0 6352400.0 1417100.0 True False 2434761.7323934003 6318178.360347326 1713409.0580699078 1.0 2.5949883622232224 0.7037276113197352 21.21534916532231 -6.68311088645259 1.890702099675832 2.0063276616806824 0.7107183631503559 0.33847592645406677 0.6755376309406319 0.43164943303356323 2.9858955281180646 0.2864088841155913 0.7524235627362833 2.0743838067658555e-07 6.68311088645259 -1.2956092985303265 YAK(ub)QHVPEQHPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YAKQHVPEQHPK 12 1 A0A1W2PNX8;Q9H3U1-2;Q9H3U1 A0A1W2PNX8 UNC45A Protein unc-45 homolog A 1 6148900.0 2779300.0 1199200.0 2170400.0 True False 3597858.638193498 1132463.4658184794 1775409.4701846116 1.0 0.31476041159501883 0.4934628201724049 21.778707072760803 -10.762091115972499 10.523077803265904 1.001869094342461 0.4041116158862885 0.9368106267996248 0.07295495280349264 0.003202587265070929 7.240491843190672e-05 0.07071482009882848 0.02354610976927294 1.729453477866938e-11 10.762091115972499 -0.5977574784561726 YAK(ub)YLPHSAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAKYLPHSAGR 11 1 M0R0F0;P46782;M0R0R2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 1 13054700.0 3876500.0 4539200.0 4639000.0 True False 5082129.0400794055 3861969.053663015 4159000.780430178 1.0 0.7599116478952439 0.8183579652604012 22.277001576576748 -9.921401862368393 5.196691580200273 1.0000005234353369 0.7891348065752688 0.9455200691936735 0.023860609157146304 1.4469464113739526e-07 3.004275680756212e-08 0.02310299278870924 0.007700978490050052 1.1983898930567702e-10 9.921401862368393 -0.21086571686006805 YAK(ub)YLPHSAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YAKYLPHSAGR 11 1 M0R0F0;P46782;M0R0R2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 1 25686100.0 5439500.0 7639600.0 12607000.0 True False 5266826.049931758 10690132.119987704 9304848.498106932 1.0 2.0297104971078768 1.7666899210061238 22.328502381000398 -10.064448868881048 5.705591351726436 0.9999958742708941 1.8982002090571728 0.9395737967864588 0.10737770055097112 5.635360522124753e-06 9.240279740281403e-07 0.10396848835255361 0.03465600383224096 8.62087069476685e-11 10.064448868881048 0.8982043347862787 YAK(ub)YLPHSAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAKYLPHSAGR 11 1 M0R0F0;P46782;M0R0R2 M0R0F0 RPS5 40S ribosomal protein S5;40S ribosomal protein S5, N-terminally processed 1 30323800.0 5439500.0 18181000.0 6703300.0 True False 4523185.2607082985 18083055.34435407 8104929.037442654 1.0 3.9978586553676543 1.7918631606465485 22.108907656434674 -6.567376669388768 2.3161494064981554 3.056651018051443 1.7960374612502228 0.0 1.306487937242021 0.7381477274601762 7.429501487556873 0.4774047017261683 1.466423510550818 2.707842065642269e-07 6.567376669388768 -1.2606135568012202 YALSVGYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YALSVGYR 8 0 P14550;Q5T621;V9GYG2;V9GYP9 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 313753000.0 83084000.0 87989000.0 142680000.0 False True 108923928.58660062 74861384.17843577 127916842.2832031 1.0 0.6872813453374186 1.174368606999903 26.698745681574838 -6.733295046618196 1.7111853871371348 0.8125117678899914 1.1742632905414383 0.5746117496255936 0.13142751195753238 0.3300322128007134 1.8946771882842761 0.06082872487996003 0.15038431642389058 1.848012708120841e-07 6.733295046618196 0.36175152265144694 YALSVGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YALSVGYR 8 0 P14550;Q5T621;V9GYG2;V9GYP9 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 191860000.0 58616000.0 18584000.0 114660000.0 False True 56755267.164776176 26004688.11427969 84627106.27373202 1.0 0.4581898634849329 1.4910881491939103 25.758250951943428 -6.764200898068837 1.596959622613486 0.6869317883070053 1.4956258418607946 0.7077740334709552 0.22804250832044698 0.2759124386115508 1.3877491591996929 0.1126277103917743 0.26951873194530196 1.7210722487844287e-07 6.764200898068837 0.8086940535537893 YALSVGYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YALSVGYR 8 0 P14550;Q5T621;V9GYG2;V9GYP9 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 137199000.0 38398000.0 42937000.0 55864000.0 False True 58252573.26981883 35274556.881687805 44822455.91393894 1.0 0.605545041217327 0.7694502302297751 25.795818445508203 -10.155871275426717 5.28081210981498 1.0000108935170238 0.6874976357234007 0.8289678532205232 0.06691401321301436 8.5822943260559e-06 1.3719718686010886e-06 0.06479147174423641 0.021596404900083088 6.984393903352601e-11 10.155871275426717 -0.31251325779362304 YALSVGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YALSVGYR 8 0 P14550;Q5T621;V9GYG2;V9GYP9 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 258460000.0 83084000.0 52276000.0 123100000.0 False True 113802400.06067652 49966273.466385305 94026315.32408127 1.0 0.4390616844613521 0.8262243614717164 26.76195574309773 -10.234793652526758 5.4300191526617745 1.0000257041454528 0.6326430229665174 0.5455385259058361 0.1580585010210039 4.918750551890567e-05 6.9317975674643244e-06 0.1530501767268157 0.05101316184838876 5.82379859711034e-11 10.234793652526758 -0.36738268117893536 YALSVGYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YALSVGYR 8 0 P14550;Q5T621;V9GYG2;V9GYP9 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 121475000.0 58616000.0 29691000.0 33168000.0 False True 48741801.12908865 29531048.6897979 40103275.44849526 1.0 0.6058669972327725 0.8227696662723858 25.538656227377704 -10.10552304263107 5.1740607429112515 1.0000067267341286 0.7143183317521524 0.6981578253037166 0.08855014383395958 6.871257845298608e-06 1.1880078254813286e-06 0.08574032617068413 0.028579436030885693 7.842905051913531e-11 10.10552304263107 -0.2856883949819762 YALSVGYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YALSVGYR 8 0 P14550;Q5T621;V9GYG2;V9GYP9 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 222229000.0 38398000.0 112890000.0 70941000.0 False True 49706967.93773749 106607572.26171455 58030465.9161291 1.0 2.1447208849119557 1.1674513317492539 25.566944767600653 -6.6076295413172375 2.162515993099215 1.7660155988164192 1.170879132505867 0.04303194299378932 0.49382730466806296 0.6192624327362706 5.484260043936081 0.1888064205212259 0.5484499637358884 2.4681437973989236e-07 6.6076295413172375 -0.5951364663105523 YALTTTLSAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YALTTTLSAR 10 0 Q9HB07;F8VR84 Q9HB07 C12orf10 UPF0160 protein MYG1, mitochondrial 0 68516000.0 25822000.0 22399000.0 20295000.0 False True 33852892.06060367 19057156.51061816 18195068.083386604 1.0 0.5629402792677776 0.5374745546352043 25.012775753056502 -13.999999999999911 0.4046684236232426 8.592082875992174 0.53614202373016 0.9998442638707884 0.0026492387725317317 27.471835339415918 0.2102122569229109 183.44798418764842 0.006433282541280521 1.0000000000002045e-14 13.999999999999911 -8.055940852262015 YALTTTLSAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YALTTTLSAR 10 0 Q9HB07;F8VR84 Q9HB07 C12orf10 UPF0160 protein MYG1, mitochondrial 0 60207000.0 25822000.0 16752000.0 17633000.0 False True 35369091.21331162 16011841.248544017 13468448.563034335 1.0 0.45270717169339514 0.38079713391011044 25.075985814579393 -13.999999999999998 0.28607762375014584 5.613352084634582 0.360415291316047 0.9996186933637582 0.005399399478514335 15.736710049105694 0.16953570928564926 42.62795313911793 0.027648697766281233 1.0000000000000041e-14 13.999999999999998 -5.2529367933185345 YALTTTLSAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YALTTTLSAR 10 0 Q9HB07;F8VR84 Q9HB07 C12orf10 UPF0160 protein MYG1, mitochondrial 0 28312800.0 15033000.0 7809000.0 5470800.0 False True 12500605.574818987 7766931.367034852 6614718.985878803 1.0 0.6213244086894821 0.5291518835858147 23.575494650189 -13.999999999999998 0.19846753824771263 3.0928571883385487 0.46837881459093617 0.9994869297031138 0.0046149164145814735 12.501041592355069 0.1412659492155471 10.149713846178997 0.05936854840926712 1.0000000000000041e-14 13.999999999999998 -2.6244783737476127 YALYDASFETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YALYDASFETK 11 0 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 34550500.0 7965500.0 11967000.0 14618000.0 False True 10442847.63801172 10181570.247000657 13105469.585757352 1.0 0.9749802544221732 1.2549708700195674 23.316011835223613 -6.885100239186604 1.0509733942702222 0.9831415501416825 1.2768587654200876 0.9775707730582779 0.018945831950580565 0.12320698095994595 0.24581324692096912 0.013816805095892276 0.033889539998682196 1.3028660302057416e-07 6.885100239186604 0.2937172152784051 YALYDASFETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YALYDASFETK 11 0 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 26457400.0 6920500.0 2900900.0 16636000.0 False True 6700812.515590171 4059244.4979936485 12278532.530697787 1.0 0.6057839237479594 1.8323945793335423 22.67590461133349 -6.8202126229208515 1.370917227492143 0.7875631203503263 1.8593026189894946 0.8848760325671532 0.1734841216533001 0.1932079345580179 0.7134430354807924 0.09944066590268665 0.22918595067969277 1.51282041689994e-07 6.8202126229208515 1.0717394986391682 YALYDASFETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YALYDASFETK 11 0 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 28274200.0 7965500.0 9837700.0 10471000.0 False True 10910560.60954356 9403037.885076499 7997965.45701426 1.0 0.861829031667867 0.7330480754598779 23.379221896746504 -6.9719731493499975 0.20569004803810376 1.0712447009915103 0.5200546559922915 0.9999939517946455 0.0002680152411220517 0.07566761963916775 0.006688654529617308 0.003991708476151587 0.013481146275670383 1.0666620665407941e-07 6.9719731493499975 -0.5511900449992188 YALYDASFETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YALYDASFETK 11 0 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 0 15400800.0 6920500.0 4979100.0 3501200.0 False True 5754702.380132693 4952276.600026027 4233284.732280257 1.0 0.8605617237692554 0.7356218363081786 22.456309886767766 -6.972426106138567 0.1915721946177386 1.0829572926949564 0.509807506276451 0.9999956372006872 0.0002254798953626315 0.0755230517407564 0.0061229031310251454 0.0043523198170206685 0.013561039664199205 1.0655501483031933e-07 6.972426106138567 -0.5731497864185054 YALYDASFETK(ub)ESR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YALYDASFETKESR 14 1 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 1 13510300.0 2288300.0 7326600.0 3895400.0 True False 2999983.4599287244 6233499.838863124 3492341.3753153128 1.0 2.0778447355210496 1.1641202099821863 21.516523115930468 -10.26541204858844 4.4571708037029785 0.9996697111240325 1.6209824727575752 0.38112628114763814 0.3730264755264177 0.001224960123557933 0.00020188476329451916 0.3613691727355498 0.12039377728118048 5.4273515254031655e-11 10.26541204858844 0.6213127616335428 YALYDASFETK(ub)ESR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YALYDASFETKESR 14 1 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 1 15809700.0 4242600.0 5005900.0 6561200.0 True False 4107920.9852818293 7004781.975423629 4842624.888219183 1.0 1.7051890726527832 1.1788505440026005 21.96997700140911 -10.457054016919418 5.653284954717303 0.9996232846007471 1.4420198083276925 0.4846304115628044 0.21487680452670443 0.001021092140979123 9.80664465784951e-05 0.20822584054521767 0.06935119045151569 3.490968926116984e-11 10.457054016919418 0.4423965237269454 YALYDASFETK(ub)ESR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YALYDASFETKESR 14 1 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 1 88267800.0 9132800.0 21911000.0 57224000.0 True False 13855125.29711445 18000810.858575616 45913651.31782981 1.0 1.2992167499433998 3.313838766033538 23.723916421924283 -6.93344849620616 0.7179290671581626 0.9729353607206668 3.7662476261893127 0.9971735342976754 0.05462733301403058 0.09088648036366212 0.06919716989229367 0.05083125003354907 0.1789580446122249 1.1656052739476718e-07 6.93344849620616 2.793312265468646 up YALYDASFETK(ub)ESR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YALYDASFETKESR 14 1 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 1 9949700.0 2288300.0 2463100.0 5198300.0 True False 3134346.348982307 2354272.097617522 3970568.6023490806 1.0 0.7511205959679382 1.2667931875615108 21.57973317745336 -6.775494859731403 1.5536628799728769 0.8582515298045118 1.2702983589621673 0.7510361690254201 0.10506398858837009 0.25764211568924333 1.228073488569589 0.05328236900765559 0.12619322409327793 1.6768921831691305e-07 6.775494859731403 0.41204682915765545 YALYDASFETK(ub)ESR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YALYDASFETKESR 14 1 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 1 13865000.0 4242600.0 4692200.0 4930200.0 True False 3527909.879047901 4666922.187271225 5961082.025330774 1.0 1.3228575409445313 1.689692262473419 21.750382276843386 -6.969462260776006 0.2707203090239027 0.909600112003838 2.1139884954483996 0.999977879575113 0.0013251542413087805 0.07647757594211324 0.009652773412801912 0.0071592185235318856 0.03408396508610965 1.0728468717906278e-07 6.969462260776006 1.2043883834445617 YALYDASFETK(ub)ESR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YALYDASFETKESR 14 1 P60981;P60981-2;F6RFD5 P60981 DSTN Destrin 1 127202800.0 9132800.0 14520000.0 103550000.0 True False 11822589.634402009 13711949.235894203 84704962.51272407 1.0 1.1598092854372983 7.164670781285092 23.495042744016732 -6.912608426922598 0.8777909838844086 0.8290633053769078 7.985586015260934 0.9918691039345094 0.2587135345580348 0.10271810667833205 0.12960052351480825 0.21458287457674463 0.6036124230297985 1.2229017685692107e-07 6.912608426922598 7.156522709884027 up YALYDATYETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YALYDATYETK 11 0 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PLJ3;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 0 232895800.0 34256000.0 100459800.0 98180000.0 False True 44909947.7355759 85471589.42923328 88021275.40906125 1.0 1.9031772188308749 1.9599505198117666 25.42053170737847 -11.038366459502349 0.4866383604235755 4.498398936297629e-14 1.9582160331447005 0.9997634130803283 0.006764031759094621 2.8982943170759428 0.2367870142252235 3.2387043963590907 0.011842276346354945 9.154477055212428e-12 11.038366459502349 1.9582160331446554 YALYDATYETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YALYDATYETK 11 0 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PLJ3;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 0 218059900.0 59645900.0 39483000.0 118931000.0 False True 57752473.55301504 55248767.80112494 87779403.24647847 1.0 0.9566476447179051 1.519924565064726 25.78337940305617 -6.888321914703371 1.0322792689879472 0.9685056124596672 1.5668045937715602 0.979801532504724 0.03637250194149388 0.12051439484062225 0.229895790027323 0.026905072220967594 0.06668081647419455 1.293236892352581e-07 6.888321914703371 0.5982989813118931 YALYDATYETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YALYDATYETK 11 0 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PLJ3;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 0 229483000.0 34256000.0 76875000.0 118352000.0 False True 46921368.933591686 73478408.30837037 90399695.13595188 1.0 1.565990293513498 1.9266210085194984 25.48374176890136 -8.741167235742255 0.11721285775638658 2.497515391174028e-08 2.8415203896174823 0.9999483092042868 0.0027419436843871647 0.28860212480852004 0.03343965527729376 0.4277591014678083 0.33484660224375307 1.8148166885250186e-09 8.741167235742255 2.8415203646423284 YALYDATYETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YALYDATYETK 11 0 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PLJ3;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 0 139317100.0 59645900.0 22336000.0 57335200.0 False True 49598208.61139473 22215671.534651108 69323725.23198767 1.0 0.4479127806552929 1.3977062311895914 25.563784678490446 -6.749094552135809 1.6529648912353032 0.6750236822427049 1.399494684743806 0.64519353297826 0.23198145348539886 0.3016093054626564 1.6210669158432829 0.11087316793887848 0.26945082989552327 1.781990760272806e-07 6.749094552135809 0.724471002501101 YALYDATYETK(ub)ESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YALYDATYETKESK 14 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PLJ3;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 1 181334000.0 46524500.0 80991200.0 53818300.0 True False 60994070.043898836 68907628.66122489 48249698.57758693 1.0 1.1297430817722196 0.7910555656125343 25.86216565222938 -6.802854975686992 1.4440866989576098 1.071328070923495 0.7860362066986379 0.8404178880569828 0.05573631376538494 0.2167063246522243 0.8918506125871768 0.030358461667470443 0.07048791550634785 1.574508553623813e-07 6.802854975686992 -0.285291864224857 YALYDATYETK(ub)ESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YALYDATYETKESK 14 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PLJ3;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 1 224971000.0 61056500.0 70657800.0 93256700.0 True False 59118294.82813837 98871828.01555938 68829972.62896864 1.0 1.6724404569344857 1.1642753369166499 25.817101322084195 -10.435421501038032 5.412393558101489 0.9996320182779463 1.4183578969255533 0.47470754653153613 0.2074575415206565 0.0009219766323237157 9.61733578111208e-05 0.2010423172139005 0.06695663361288474 3.6692601052223854e-11 10.435421501038032 0.4187258786476069 YALYDATYETK(ub)ESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YALYDATYETKESK 14 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PLJ3;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 1 524839000.0 146060000.0 203551000.0 175228000.0 True False 221583698.41631714 167225733.69877785 140594108.99483916 1.0 0.7546842790961538 0.6344966258785307 27.723276507457946 -13.999999999999998 0.09356467627440354 2.2380146882325156 0.3509114454795997 0.9998254365458492 0.002009612511643524 12.13247488534296 0.0897285794619993 2.953066090795965 0.25402781224343124 1.0000000000000041e-14 13.999999999999998 -1.887103242752916 YALYDATYETK(ub)ESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YALYDATYETKESK 14 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PLJ3;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 1 149909000.0 46524500.0 58110000.0 45274500.0 True False 63725864.9273378 55542508.05592714 34581595.55759641 1.0 0.8715850011491947 0.5426618469129828 25.92537571375227 -6.954939860443462 0.5016957656872713 1.0064915890090287 0.39352766942864004 0.9995340633391191 0.0041572900831456545 0.08156078705026173 0.028207430174192753 0.004860019961138429 0.027134840902218998 1.1093284204843446e-07 6.954939860443462 -0.6129639195803886 YALYDATYETK(ub)ESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YALYDATYETKESK 14 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PLJ3;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 1 210684400.0 61056500.0 108760000.0 40867900.0 True False 50771185.01157027 108174088.29283035 49413188.93818016 1.0 2.130619725897249 0.9732526220713456 25.59750659751847 -6.6515468798632815 2.0034372003719265 1.732774086802623 0.9781568800122008 0.2002264655596232 0.48238055474225644 0.5047182858588936 3.8849431192369193 0.19517344159095987 0.5342046675426054 2.2307613952264445e-07 6.6515468798632815 -0.7546172067904221 YALYDATYETK(ub)ESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YALYDATYETKESK 14 1 P23528;E9PK25;E9PP50;G3V1A4;E9PQB7;E9PLJ3;Q9Y281;Q9Y281-3 P23528 CFL1;CFL2 Cofilin-1;Cofilin-2 1 505922000.0 146060000.0 189690000.0 170172000.0 True False 189077549.2730336 179133584.74908885 139202442.11217085 1.0 0.9474080102995974 0.7362187771492552 27.494402829550395 -6.944785347863045 0.6134329107094634 1.0023255666321513 0.6702382022549308 0.9987258562775837 0.004068953229523498 0.08564980504258528 0.04516698654170092 0.004122664339638387 0.017829783064973816 1.1355719388856958e-07 6.944785347863045 -0.33208736437722053 YANEVNSDAGAFK(ub)NSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YANEVNSDAGAFKNSLK 17 1 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 1 7273300.0 1693700.0 1763700.0 3815900.0 True False 1639934.4205845082 2467954.6075739935 2816401.3154538157 1.0 1.5049105480049385 1.7173865491828564 20.645206693320464 -11.11414695434268 0.16357960567629615 2.9376457639301736e-18 1.9596776092863595 0.9995649140819384 0.006275832969325205 3.398198067835025 0.09599110590190302 1.4393602724548067 0.1771532633954478 7.688702298939057e-12 11.11414695434268 1.9596776092863595 YANEVNSDAGAFK(ub)NSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YANEVNSDAGAFKNSLK 17 1 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 1 34823000.0 4523600.0 8722400.0 21577000.0 True False 6862631.919458109 7165819.571577744 17312296.492464922 1.0 1.0441795007626717 2.522690521019805 22.710330546442922 -6.913280553124359 0.8730870595895225 0.9588339642190636 2.727809864143258 0.9921019895053783 0.06288671059633576 0.1022887201916195 0.1272924005883015 0.05233628830653183 0.14797851300086387 1.2210106355912068e-07 6.913280553124359 1.7689758999241945 up YANEVNSDAGAFK(ub)NSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YANEVNSDAGAFKNSLK 17 1 Q9UHB9-4;Q9UHB9;Q9UHB9-2;Q9UHB9-3 Q9UHB9-4 SRP68 Signal recognition particle subunit SRP68 1 36895900.0 4523600.0 9888300.0 22484000.0 True False 5855889.373486883 9338007.41248571 18392142.705321975 1.0 1.5946352154062984 3.1407940847711733 22.48145686853537 -6.954614290683146 0.5056574287555576 0.9704968238262107 3.8322646298843193 0.9995154020593926 0.019862708130649054 0.081684112968947 0.028691094768480474 0.02305327157709335 0.12757519529367797 1.11016034262577e-07 6.954614290683146 2.8617678060581087 YANGETSK(ub)GDELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YANGETSKGDELR 13 1 A6NHB5;Q14202-2;Q14202 A6NHB5 ZMYM3 Zinc finger MYM-type protein 3 1 29607500.0 2200400.0 4600900.0 22806200.0 True False 3338167.6707877833 3779833.448004224 18298544.573687427 1.0 1.1323078469309513 5.4816133814420125 21.67062499009385 -6.913391318931715 0.8723144586147428 0.879346861933051 6.0864665620981215 0.9921398299187054 0.18460004241034833 0.10221809181115227 0.12691612647111863 0.15371586979712992 0.43499476112525054 1.2206992593503782e-07 6.913391318931715 5.20711970016507 up YANGETSK(ub)GDELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YANGETSKGDELR 13 1 A6NHB5;Q14202-2;Q14202 A6NHB5 ZMYM3 Zinc finger MYM-type protein 3 1 42102500.0 2200400.0 0.0 39902100.0 True False 2848461.1763684964 0.0 32640327.230120435 1.0 0.0 11.458933511508693 21.441751312186298 -6.885643025347797 1.0477921042262985 0.3184677525619072 12.364392744686583 0.9779606926950261 0.7693303205387173 0.12275033467382077 0.24305769676923572 0.5623980081434088 1.381811869820737 1.3012387106213068e-07 6.885643025347797 12.045924992124675 up YANNSNYK(ub)NDVMIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YANNSNYKNDVMIR 14 1 P61326;Q96A72;P61326-2;F5H6N1 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 26418100.0 3758600.0 7416500.0 15243000.0 True False 4927560.9983341815 6309987.109290572 13665800.581180705 1.0 1.2805497712608196 2.7733397081843503 22.232442299841953 -6.9384272458230285 0.6740343921455133 0.9827007615461665 3.157933765862827 0.9979505865640679 0.035234330479290976 0.08849148518922421 0.05793194929467068 0.033902323047895984 0.1293970409224316 1.1523190832423528e-07 6.9384272458230285 2.1752330043166603 up YANNSNYK(ub)NDVMIR ddPTM_RPMI8226_Bortezomib_2h_R1 2 YANNSNYKNDVMIR 14 1 P61326;Q96A72;P61326-2;F5H6N1 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 39264400.0 7492600.0 9045300.0 22726500.0 True False 7254751.5142418835 12657135.460616363 16773747.869614268 1.0 1.7446683646943661 2.312105085430636 22.7904947700655 -6.974141046711019 0.12433523594007272 0.043794362313420765 4.0276039971715605 0.9999993567171781 0.0004308951558603483 0.0749804721154638 0.0037153319580442586 0.03803174559379564 0.07985146220358974 1.0613508041377786e-07 6.974141046711019 3.9838096348581398 YANNSNYK(ub)NDVMIR ddPTM_RPMI8226_Bortezomib_8h_R1 2 YANNSNYKNDVMIR 14 1 P61326;Q96A72;P61326-2;F5H6N1 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 89286000.0 7882900.0 27535100.0 53868000.0 True False 11958935.617184611 22621246.27228177 43220966.18881684 1.0 1.8915768924933216 3.6141147985368933 23.511585655073386 -6.960715586176527 0.4252285160910227 0.9280128145700585 4.643217935825107 0.9997958253105632 0.015503984043298995 0.07944648422352235 0.020194091118914067 0.022366891878520655 0.14318962120285547 1.0946730187455289e-07 6.960715586176527 3.7152051212550488 YANNSNYK(ub)NDVMIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YANNSNYKNDVMIR 14 1 P61326;Q96A72;P61326-2;F5H6N1 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 32402700.0 3758600.0 5171100.0 23473000.0 True False 5148255.992345803 4942623.7034590505 17929160.841609742 1.0 0.9600578741242709 3.4825697999994594 22.295652361364844 -6.90330277677257 0.9401432309544759 0.9044138803609282 3.7658594411042237 0.988139272223718 0.12849081174384958 0.10901512943674185 0.16402248805773098 0.10183131236940246 0.26962221881066645 1.2493876917965123e-07 6.90330277677257 2.8614455607432956 up YANNSNYK(ub)NDVMIR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 YANNSNYKNDVMIR 14 1 P61326;Q96A72;P61326-2;F5H6N1 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 40970900.0 7492600.0 17252300.0 16226000.0 True False 6230428.878459974 17159358.43558659 19618781.579452626 1.0 2.7541215493062507 3.148865344933038 22.570900045499776 -10.034549761593912 0.35701086756247025 4.745787205809607e-26 3.2242614372787255 0.9988583645297032 0.03155644035073293 1.401186245580134 0.1603468793188842 1.5633718046686025 0.11393999173999919 9.235283641960199e-11 10.034549761593912 3.2242614372787255 YANNSNYK(ub)NDVMIR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 YANNSNYKNDVMIR 14 1 P61326;Q96A72;P61326-2;F5H6N1 P61326 MAGOH;MAGOHB Protein mago nashi homolog;Protein mago nashi homolog 2 1 55099000.0 7882900.0 19674600.0 27541500.0 True False 10204569.445189612 18579691.214636628 22529229.599654216 1.0 1.8207226982413267 2.2077589574613943 23.282711977165835 -9.885696576344673 0.18529827490331005 1.893468120922165e-24 2.6141348366028656 0.9995289412036588 0.010928994376128886 1.38630265612342 0.08284973508105983 0.9616826417920497 0.2551046347807988 1.3010782703277416e-10 9.885696576344673 2.6141348366028656 YAPDK(ub)QAPGSDSQPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAPDKQAPGSDSQPR 15 1 Q9NXE4-3;Q9NXE4-2;Q9NXE4;Q9NXE4-4;H7C1Q6;Q9NXE4-6;Q9NXE4-9;Q9NXE4-10;Q9NXE4-7;Q9NXE4-8;H7C2J2;H7C0W5;H7C2E2 Q9NXE4-3 SMPD4 Sphingomyelin phosphodiesterase 4 1 7574300.0 2361100.0 2254700.0 2958500.0 True False 3095424.964924928 1918307.5487517656 2652382.7999359113 1.0 0.6197234856243041 0.8568719416528446 21.56170605718133 -10.457692832351796 5.797737979149252 1.0001877814354647 0.7382977136385743 0.6188628689881686 0.09681545175979685 0.00023516153529875593 2.1996548730900264e-05 0.09380782799610331 0.031247052693436642 3.4858377407696525e-11 10.457692832351796 -0.2618900677968904 YAPDK(ub)QAPGSDSQPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YAPDKQAPGSDSQPR 15 1 Q9NXE4-3;Q9NXE4-2;Q9NXE4;Q9NXE4-4;H7C1Q6;Q9NXE4-6;Q9NXE4-9;Q9NXE4-10;Q9NXE4-7;Q9NXE4-8;H7C2J2;H7C0W5;H7C2E2 Q9NXE4-3 SMPD4 Sphingomyelin phosphodiesterase 4 1 10045100.0 1411700.0 1697500.0 6935900.0 True False 1366886.356225513 2375320.6023455597 5119179.717460131 1.0 1.7377601228713064 3.7451392313228666 20.382461870698812 -6.9536227561095885 0.5175455520640956 0.9652308297504917 4.606876384029273 0.9994557763601312 0.027060339274534512 0.08206281301924614 0.03018810125352791 0.030777079042410383 0.16577214818094496 1.112697837196699e-07 6.9536227561095885 3.6416455542787816 YAPDK(ub)QAPGSDSQPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YAPDKQAPGSDSQPR 15 1 Q9NXE4-3;Q9NXE4-2;Q9NXE4;Q9NXE4-4;H7C1Q6;Q9NXE4-6;Q9NXE4-9;Q9NXE4-10;Q9NXE4-7;Q9NXE4-8;H7C2J2;H7C0W5;H7C2E2 Q9NXE4-3 SMPD4 Sphingomyelin phosphodiesterase 4 1 34007700.0 2543300.0 6999400.0 24465000.0 True False 3858372.040135686 5750302.383438189 19629482.026609577 1.0 1.4903441979213519 5.087503699078038 21.879560830020825 -6.9317453137743135 0.7323241945480943 0.9486856156852053 5.859912562156163 0.9968702823032171 0.10194770007869708 0.09174167400815003 0.07331442444766653 0.09386271710875246 0.32241397502006003 1.170185429530599e-07 6.9317453137743135 4.911226946470958 up YAPDK(ub)QAPGSDSQPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YAPDKQAPGSDSQPR 15 1 Q9NXE4-3;Q9NXE4-2;Q9NXE4;Q9NXE4-4;H7C1Q6;Q9NXE4-6;Q9NXE4-9;Q9NXE4-10;Q9NXE4-7;Q9NXE4-8;H7C2J2;H7C0W5;H7C2E2 Q9NXE4-3 SMPD4 Sphingomyelin phosphodiesterase 4 1 7318400.0 2361100.0 1437800.0 3519500.0 True False 3234062.476328334 1374273.2418312188 2688266.5863777744 1.0 0.42493713460707355 0.8312352052733973 21.62491611870422 -9.964520676648348 5.71096235379351 1.000000453794152 0.6280861699399969 0.5276797558946695 0.16587049276920887 9.582800115158477e-07 1.739060721982736e-07 0.16060361026499334 0.05353447134339679 1.0851238859344133e-10 9.964520676648348 -0.37191428385415515 YAPDK(ub)QAPGSDSQPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAPDKQAPGSDSQPR 15 1 Q9NXE4-3;Q9NXE4-2;Q9NXE4;Q9NXE4-4;H7C1Q6;Q9NXE4-6;Q9NXE4-9;Q9NXE4-10;Q9NXE4-7;Q9NXE4-8;H7C2J2;H7C0W5;H7C2E2 Q9NXE4-3 SMPD4 Sphingomyelin phosphodiesterase 4 1 8520500.0 1411700.0 2617600.0 4491200.0 True False 1173891.0989138556 2603498.469247079 5430289.155037448 1.0 2.2178364514868285 4.625888346935955 20.162867146133088 -6.96026728982745 0.4316502656369718 0.906005974877783 6.0303157042335815 0.9997799845954829 0.02234744252406552 0.07960577712703545 0.020779534569815093 0.03145137676771293 0.19986742739839594 1.0958035679584291e-07 6.96026728982745 5.124309729355798 YAPDK(ub)QAPGSDSQPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YAPDKQAPGSDSQPR 15 1 Q9NXE4-3;Q9NXE4-2;Q9NXE4;Q9NXE4-4;H7C1Q6;Q9NXE4-6;Q9NXE4-9;Q9NXE4-10;Q9NXE4-7;Q9NXE4-8;H7C2J2;H7C0W5;H7C2E2 Q9NXE4-3 SMPD4 Sphingomyelin phosphodiesterase 4 1 25295400.0 2543300.0 4882100.0 17870000.0 True False 3292351.9859380075 4610406.843289188 14617843.361684013 1.0 1.4003383790617576 4.439939418421362 21.650687152113274 -6.931082136673445 0.7378557029307663 0.9555832985729316 5.081504993006043 0.9967466889400611 0.08760793015041332 0.09207977376948302 0.07495595398197286 0.08033507365534041 0.27341310121342377 1.1719736930932426e-07 6.931082136673445 4.125921694433112 up YAPSGFYIASGDVSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAPSGFYIASGDVSGK 16 0 O75083;D6RD66 O75083 WDR1 WD repeat-containing protein 1 0 46978900.0 15138000.0 9422900.0 22418000.0 False True 19846064.59660052 8017040.050176521 20098400.408640634 1.0 0.4039611990152334 1.012714652359004 24.242349618690415 -10.83342253558605 12.07073984186563 1.0028455532926004 0.7083379256871188 0.2343421956103573 0.24852255664156736 0.019097605982738203 0.0002635483576513456 0.24146916269034416 0.08021031025247334 1.4674978188096917e-11 10.83342253558605 -0.29450762760548155 YAPSGFYIASGDVSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YAPSGFYIASGDVSGK 16 0 O75083;D6RD66 O75083 WDR1 WD repeat-containing protein 1 0 22498100.0 5651800.0 2669300.0 14177000.0 False True 5472386.702638908 3735165.4102156074 10463618.399116518 1.0 0.6825477827461327 1.9120758396095665 22.383738750254743 -6.838167936664381 1.2908418023482442 0.8310597286563266 1.9510797932681658 0.9212634241592151 0.1462355360688988 0.17094965814507085 0.5541065439451046 0.08885689575371222 0.20462356580047245 1.4515502113342866e-07 6.838167936664381 1.1200200646118392 YAPSGFYIASGDVSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YAPSGFYIASGDVSGK 16 0 O75083;D6RD66 O75083 WDR1 WD repeat-containing protein 1 0 36015800.0 15138000.0 8819800.0 12058000.0 False True 20734927.68906791 8430112.072821671 9210148.74230523 1.0 0.40656578114165715 0.4441852356765682 24.305559680213307 -9.886215577934742 5.688213243103162 1.0000002654243871 0.42537551085511344 0.9967957659368661 0.015358078006436935 5.1708333333280094e-08 1.0089436638670289e-08 0.014870401954245329 0.004956798361753227 1.2995243515105767e-10 9.886215577934742 -0.5746247545692738 YAPSGFYIASGDVSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAPSGFYIASGDVSGK 16 0 O75083;D6RD66 O75083 WDR1 WD repeat-containing protein 1 0 17928400.0 5651800.0 6550900.0 5725700.0 False True 4699722.117192975 6515609.001448158 6922917.397354362 1.0 1.386381755979174 1.473048240879664 22.16414402568902 -12.201662754573865 0.24061882163724785 1.3837410916518046e-06 1.514402463677191 0.9993920475097097 0.0050703076745082605 5.744950993770837 0.14396061841546973 2.8671333538916706 0.04211856844483435 6.285462583330627e-13 12.201662754573865 1.5144010799360992 YAPTEAQLNAVDALIDSMSLAK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 YAPTEAQLNAVDALIDSMSLAKK 23 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 10203600.0 3764400.0 2807800.0 3631400.0 True False 3644901.1825283854 3928969.182483569 2680227.4003351736 1.0 1.0779357205393787 0.7353360944825288 21.79744827128139 -6.846917582629393 1.2499809326272302 1.0415025971053693 0.7224414301473852 0.9356824061681218 0.03718596259839201 0.16088216044128814 0.4852939770796937 0.02329687465680818 0.053811415443403766 1.4225987323498358e-07 6.846917582629393 -0.31906116695798414 YASENVNK(ub)LLVGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YASENVNKLLVGNK 14 1 E9PLD0;Q9H0U4;E7END7;P62820-2;P62820 E9PLD0;E7END7 RAB1B;RAB1A Ras-related protein Rab-1B;Ras-related protein Rab-1A 1 77171000.0 19796000.0 32151000.0 25224000.0 True False 25952747.70473673 27354196.123616423 22614062.44569322 1.0 1.0540000016500723 0.871355230011574 24.629383953859964 -6.827538965033304 1.3390951975372494 1.0289065129755948 0.8666909072967879 0.9008065196007629 0.024128946714279904 0.18387890479915472 0.6457571117292075 0.014151845722190769 0.03256872492508799 1.487513907891019e-07 6.827538965033304 -0.16221560567880688 YASENVNK(ub)LLVGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YASENVNKLLVGNK 14 1 E9PLD0;Q9H0U4;E7END7;P62820-2;P62820 E9PLD0;E7END7 RAB1B;RAB1A Ras-related protein Rab-1B;Ras-related protein Rab-1A 1 81594000.0 24799000.0 30664000.0 26131000.0 True False 24011769.31928628 42908295.11064751 19286507.186803542 1.0 1.7869693207565307 0.8032105810425473 24.51723837740558 -6.693667367566985 1.8531432286732255 1.4916786255484404 0.806433840577121 0.38766768261434137 0.33259034770270063 0.40888074083692116 2.7251062998993087 0.14341806132942891 0.3717865711246072 2.0245692318923172e-07 6.693667367566985 -0.6852447849713195 YASENVNK(ub)LLVGNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YASENVNKLLVGNK 14 1 E9PLD0;Q9H0U4;E7END7;P62820-2;P62820 E9PLD0;E7END7 RAB1B;RAB1A Ras-related protein Rab-1B;Ras-related protein Rab-1A 1 83946000.0 27847000.0 34782000.0 21317000.0 True False 42245934.88839638 28574880.346993625 17103685.606426973 1.0 0.676393608579893 0.4048599149624882 25.332309189073623 -7.3725964907818256 0.20377928357175115 1.1820966331451601 6.45105371569535e-16 0.9999672159372555 0.0013929151478028505 0.11669442515998513 0.014842701253378816 0.02314885406989975 0.05389181579582604 4.2403676170416606e-08 7.3725964907818256 -1.1820966331451594 down YASENVNK(ub)LLVGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YASENVNKLLVGNK 14 1 E9PLD0;Q9H0U4;E7END7;P62820-2;P62820 E9PLD0;E7END7 RAB1B;RAB1A Ras-related protein Rab-1B;Ras-related protein Rab-1A 1 71769000.0 19796000.0 21061000.0 30912000.0 True False 27115116.166784853 20130455.38058652 23611222.252623912 1.0 0.742407122903854 0.8707771011339757 24.692594015382856 -10.14995989906695 4.8008268255223605 1.0000160538323601 0.806592112017821 0.7516537238383841 0.05240682416309622 13404344.62633212 28339610.00731633 1488.3140260452524 0.01794025599747924 7.080111561500711e-11 10.14995989906695 -0.19342394181453915 YASENVNK(ub)LLVGNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YASENVNKLLVGNK 14 1 E9PLD0;Q9H0U4;E7END7;P62820-2;P62820 E9PLD0;E7END7 RAB1B;RAB1A Ras-related protein Rab-1B;Ras-related protein Rab-1A 1 64356000.0 24799000.0 25070000.0 14487000.0 True False 20621467.281975392 24934942.933994602 17516164.719680127 1.0 1.2091740414509442 0.8494140829149671 24.297643652839856 -6.749078656315449 1.6532008707219952 1.123132305567121 0.8487467643727274 0.6450160284136222 0.08789269985422353 0.3016564714587246 1.6218093687757114 0.042002895245244316 0.10207264841166618 1.7820559849638542e-07 6.749078656315449 -0.2743855411943935 YASGLLK(ub)AGLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YASGLLKAGLIR 12 1 I3L2N2;O14641;I3L0Z8 I3L2N2 DVL2 Segment polarity protein dishevelled homolog DVL-2 1 10038800.0 1374500.0 2638100.0 6026200.0 True False 1330867.249863262 3691507.087509755 4447757.437875145 1.0 2.7737605594314787 3.341999315357804 20.343935243116945 -9.707352308191538 0.3096115893880555 7.713782329483762e-23 3.5361669557618325 0.998740681768215 0.03539623201273344 1.0788242651962296 0.13091487844316485 1.2405648199858368 0.19305985367865341 1.9617682063639837e-10 9.707352308191538 3.5361669557618325 YASICQQNGIVPIVEPEILPDGDHDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YASICQQNGIVPIVEPEILPDGDHDLK 27 0 P04075;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 0 39302100.0 21002000.0 6626100.0 11674000.0 False True 20335303.005913563 9271936.28465501 8616229.187506972 1.0 0.45595269871113825 0.42370793221037073 24.277483152030122 -13.963856257375301 0.4022695174858869 9.999988848975454 0.42189543224440706 0.9998403841862985 0.0033403318418837097 26.275615498330097 0.2091295723915244 206.35560962166613 0.008202521321072152 1.0867852678765853e-14 13.963856257375301 -9.578093416731047 YASICQQNGIVPIVEPEILPDGDHDLK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 YASICQQNGIVPIVEPEILPDGDHDLKR 28 1 P04075;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 1 97887100.0 18431000.0 33823000.0 45633100.0 True False 24163219.486057878 28776740.24102141 40911424.55560431 1.0 1.1909315419505884 1.6931280444317491 24.526309355096625 -6.95436430078254 0.5086800280279595 0.9906562399766398 1.915385961476443 0.999500764255962 0.006531575082570382 0.08177915348084976 0.029065161622173482 0.007540350339432974 0.04144395268497577 1.1107995604298406e-07 6.95436430078254 0.9247297214998033 YASICQQNGIVPIVEPEILPDGDHDLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 YASICQQNGIVPIVEPEILPDGDHDLKR 28 1 P04075;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 1 159580400.0 65243400.0 43495000.0 50842000.0 True False 63172283.979431584 60862780.323428586 37524954.97269398 1.0 0.9634411879621931 0.5940097873445864 25.91278839768096 -6.926026160128766 0.778722837172215 1.0065221065482877 0.525312260216681 0.9956978317790823 0.012027864803384825 0.09475450610285834 0.08817914542726465 0.010709154396184806 0.03418664663725058 1.1856973244438697e-07 6.926026160128766 -0.4812098463316067 YASICQQNGIVPIVEPEILPDGDHDLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 YASICQQNGIVPIVEPEILPDGDHDLKR 28 1 P04075;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 1 1383757000.0 171979000.0 330400000.0 881378000.0 True False 260904716.34903306 271437538.57301736 707173251.9782985 1.0 1.0403703787780276 2.7104655748432562 27.9589477829471 -6.912101007049527 0.8813101538391009 0.9516631347895335 2.9362819193819543 0.9916904727583102 0.07264965117297446 0.1030448881434918 0.13135409880100568 0.06010416717286707 0.16843115486825358 1.224331414421933e-07 6.912101007049527 1.9846187845924208 up YASICQQNGIVPIVEPEILPDGDHDLK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YASICQQNGIVPIVEPEILPDGDHDLKR 28 1 P04075;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 1 120238000.0 18431000.0 43357000.0 58450000.0 True False 25245438.77904681 41441344.377574235 44645313.81553659 1.0 1.6415378928557063 1.7684506974222713 24.589519416619517 -11.320509351526951 0.28931063615748037 1.6905503769052503e-22 1.8088548708856906 0.9993131173194972 0.008815262415929549 3.524791293338473 0.15368124276995318 2.29438213812945 0.047929067139375434 4.780690719268108e-12 11.320509351526951 1.8088548708856906 YASICQQNGIVPIVEPEILPDGDHDLK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YASICQQNGIVPIVEPEILPDGDHDLKR 28 1 P04075;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 1 174510600.0 65243400.0 19176000.0 90091200.0 True False 54252777.872689806 19072695.081862036 108928853.38535576 1.0 0.3515524150047808 2.007802321956112 25.693193673115235 -6.800531792605808 1.4539336577860218 0.6424670154502237 2.0309160157604818 0.8336615715922959 0.2779249392336042 0.22000002587837228 0.9181239742710525 0.15038244982881704 0.34959124044818995 1.5829536820552681e-07 6.800531792605808 1.388449000310258 up YASICQQNGIVPIVEPEILPDGDHDLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YASICQQNGIVPIVEPEILPDGDHDLKR 28 1 P04075;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 1 1015829000.0 171979000.0 301380000.0 542470000.0 True False 222630205.71290573 284607938.0656882 443746026.2122397 1.0 1.278388694626219 1.993197754955477 27.73007410503955 -6.9548869640584945 0.5023400563465701 0.9859704056525084 2.316569180103452 0.9995310687492909 0.00905855477396428 0.08158076835131763 0.02828558731228706 0.01057717506837665 0.05897044149320113 1.1094635431702378e-07 6.9548869640584945 1.3305987744509435 YASICQQNGIVPIVEPEILPDGDHDLKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YASICQQNGIVPIVEPEILPDGDHDLKR 28 1 P04075;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 0 97015900.0 5198100.0 58353800.0 33464000.0 False True 6814759.438472014 49647640.50133087 30001466.289354507 1.0 7.285310794838963 4.402424848628457 22.700231300008518 -9.202823086935522 9.958365350959701 1.0000000337761306 5.843867821742547 0.7900995260227263 1.1769332591448147 0.0 0.0 1.13956069410388 0.37985357602181136 6.268691724548918e-10 9.202823086935522 4.843867787966417 YASICQQNGIVPIVEPEILPDGDHDLKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YASICQQNGIVPIVEPEILPDGDHDLKR 28 1 P04075;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 0 73538000.0 30118000.0 14108000.0 29312000.0 False True 29161920.575759694 19741397.972248085 21634307.85884907 1.0 0.6769580872069776 0.7418684171587858 24.797582401499188 -10.783607405357774 7.063590488768675 1.0086053212737216 0.7094132521834396 0.9639270646918483 0.026499531236270996 0.003626551534298477 0.00011109902550126985 0.025911048396080612 0.00855268693003173 1.6458588786726333e-11 10.783607405357774 -0.29919206909028195 YASICQQNGIVPIVEPEILPDGDHDLKR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YASICQQNGIVPIVEPEILPDGDHDLKR 28 1 P04075;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 0 780126000.0 16439000.0 724785000.0 38902000.0 False True 24939164.85188168 595441453.9789486 31213002.648647685 1.0 23.875757569084037 1.2515656732704359 24.571909818063066 -4.315481146212665 9.781193465974788 9.999999999994209 12.98026139763582 0.0 10.802341586974686 0.0 0.0 3.2145876573991368 0.0 4.8363625968108874e-05 4.315481146212665 2.980261397641611 YASICQQNGIVPIVEPEILPDGDHDLKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YASICQQNGIVPIVEPEILPDGDHDLKR 28 1 P04075;P04075-2;H3BQN4;H3BPS8;P09972 P04075;P09972 ALDOA;ALDOC Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase;Fructose-bisphosphate aldolase C 0 163743100.0 5198100.0 104830000.0 53715000.0 False True 7119978.043370598 100198263.97354753 41028623.29515056 1.0 14.072833281675917 5.762464862283144 22.76344136153141 -9.495050823883172 8.086491105816135 1.000011159672891 9.917649071980344 0.6055724886377105 3.3926937003510544 0.0 0.0 3.284961403208942 1.0949871833521734 3.1985207766860395e-10 9.495050823883172 8.917637912307454 YATALYSAASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YATALYSAASK 11 0 P48047;A0A494C0K9;H7C0C1;H7C086 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 18001800.0 5340500.0 7017500.0 5643800.0 False True 7001447.21747556 5970516.354000756 5059833.715152375 1.0 0.852754604662075 0.7226839763246473 22.739221731049447 -6.972586305077796 0.18632751142077625 1.0924991859601496 0.4793995078681843 0.9999961559064173 0.00022203784266661692 0.07547213306215599 0.005918762566731526 0.004739188035342227 0.01432664337163622 1.0651571695037007e-07 6.972586305077796 -0.6130996780919653 YATALYSAASK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YATALYSAASK 11 0 P48047;A0A494C0K9;H7C0C1;H7C086 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 16157900.0 5651900.0 2618800.0 7887200.0 False True 5472483.528193648 3664500.496861586 5821305.709071858 1.0 0.6696229377361252 1.0637411111575057 22.383764276322154 -6.684328374290267 1.8863225076058976 0.7917884101014382 1.0623031347920702 0.34414549545771267 0.1398903810675001 0.42896679095606655 2.9546010965468352 0.05942437345920281 0.15587474637658685 2.068576686345068e-07 6.684328374290267 0.270514724690632 YATALYSAASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YATALYSAASK 11 0 P48047;A0A494C0K9;H7C0C1;H7C086 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 17681300.0 5340500.0 5787600.0 6553200.0 False True 7315027.171585885 5531884.694966166 5005469.127390495 1.0 0.7562357001835802 0.6842721168327961 22.80243179257234 -13.999999999999998 0.17101670620810827 2.2326164094530974 0.6214742333209345 0.9995117736845961 0.002985286458866534 12.101544072258722 0.1309747277320058 4.948931353745605 0.05813219330693353 1.0000000000000041e-14 13.999999999999998 -1.6111421761321627 YATALYSAASK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YATALYSAASK 11 0 P48047;A0A494C0K9;H7C0C1;H7C086 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 9425000.0 5651900.0 2357000.0 1416100.0 False True 4699805.271623729 2344302.373172131 1712199.9626933844 1.0 0.49880840538786864 0.36431295846047657 22.16416955175643 -13.999999999999998 0.18462768983114913 3.6387217223359833 0.26242965518928196 0.9994932809181083 0.006157328272972374 12.268122234401421 0.13624499362134773 11.626654540113535 0.09660482255087657 1.0000000000000041e-14 13.999999999999998 -3.3762920671467014 YATALYSAASK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YATALYSAASK 11 0 P48047;A0A494C0K9;H7C0C1;H7C086 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 9134500.0 2921900.0 3900500.0 2312100.0 False True 3782457.1492597326 3683433.7461849414 1891321.5241493918 1.0 0.9738203503259327 0.5000245738460101 21.850892307840038 -6.918296182666232 0.8372658653338149 1.0111097914597555 0.4265367326469808 0.9936943750258144 0.018245470590690586 0.09918483076853478 0.11088551914729416 0.015580106009927666 0.045936075599620665 1.206990404047829e-07 6.918296182666232 -0.5845730588127748 YATLSLFNTYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YATLSLFNTYK 11 0 E7EPN9;Q9Y520-3;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7 E7EPN9 PRRC2C Protein PRRC2C 0 23549300.0 8067100.0 12154000.0 3328200.0 False True 10576046.221907537 10340670.575920947 2983829.7903487217 1.0 0.977744457517685 0.2821309332184959 23.334297051386407 -6.913714725139663 0.8700651323337244 1.0190908985249054 0.18471130415236972 0.9922492155859244 0.029341916110595015 0.1020126597371372 0.12582566106599374 0.02447279751217118 0.0694271405855858 1.2197905792258948e-07 6.913714725139663 -0.8343795943725357 down YATLSLFNTYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YATLSLFNTYK 11 0 E7EPN9;Q9Y520-3;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7 E7EPN9 PRRC2C Protein PRRC2C 0 27434600.0 11557000.0 6295500.0 9582100.0 False True 11190129.360981962 8809325.980598796 7072260.553161777 1.0 0.7872407633923685 0.6320088289436153 23.415723378574853 -6.974561784808438 0.10119180405756406 1.3760826478698225 0.03922680255007431 0.9999997307291232 7.806090610063888e-05 0.07484823284461974 0.0029727289875163395 0.013789823674203916 0.02522764682865839 1.0603230810130776e-07 6.974561784808438 -1.336855845319748 YATLSLFNTYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YATLSLFNTYK 11 0 E7EPN9;Q9Y520-3;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7 E7EPN9 PRRC2C Protein PRRC2C 0 20177400.0 6488100.0 6154400.0 7534900.0 False True 9842922.043645807 5056099.235453322 6045623.712336009 1.0 0.5136786833252769 0.6142102604824368 23.230655237741857 -10.01140468160779 5.983163631840132 1.0000005304131 0.5639444719038517 0.9616640651399516 0.04104184451221086 2.904157464968935e-07 4.7901395142353055e-08 0.03973864362754028 0.013246198357761517 9.74081552030648e-11 10.01140468160779 -0.43605605850924845 YATLSLFNTYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YATLSLFNTYK 11 0 E7EPN9;Q9Y520-3;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7 E7EPN9 PRRC2C Protein PRRC2C 0 29997000.0 8067100.0 9962900.0 11967000.0 False True 11049724.875180341 9522706.135095453 9140641.068101402 1.0 0.8618048180081981 0.8272279329445493 23.3975071129093 -13.999999999999998 0.19456637455864104 1.7528720757920289 0.8035304355827848 0.9994875339993121 0.0016897277637474366 12.428615256133716 0.1398793344833272 3.5532546702717167 0.022943204041142626 1.0000000000000041e-14 13.999999999999998 -0.949341640209244 YATLSLFNTYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YATLSLFNTYK 11 0 E7EPN9;Q9Y520-3;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7 E7EPN9 PRRC2C Protein PRRC2C 0 21583800.0 11557000.0 5366400.0 4660400.0 False True 9610157.56190934 5337490.138053004 5634868.092745028 1.0 0.5554008978175956 0.5863450267537025 23.19612865400913 -9.991445328191057 5.231854002999141 1.000002090100869 0.5708729622858084 0.9961153156248349 0.012632887745161386 3.344582353969932e-07 6.44683349810102e-08 0.012231805655379124 0.004077246986600589 1.0198931427339623e-10 9.991445328191057 -0.42912912781506063 YATLSLFNTYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YATLSLFNTYK 11 0 E7EPN9;Q9Y520-3;Q9Y520-6;Q9Y520-4;Q9Y520-5;Q9Y520;Q9Y520-7 E7EPN9 PRRC2C Protein PRRC2C 0 31081100.0 6488100.0 14448000.0 10145000.0 False True 8398973.349571194 13643956.099187274 8298714.0964904595 1.0 1.6244790322955196 0.9880629156793487 23.001781559834306 -6.650554135447023 2.0069279842454595 1.405063911483473 0.9907607049651942 0.19610664929886557 0.26650190537495816 0.5072094375495039 3.9165836380766317 0.10768044354879928 0.29512510982305107 2.235866477300827e-07 6.650554135447023 -0.4143032065182789 YATTGK(ub)CELENCQPFVVETLHGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YATTGKCELENCQPFVVETLHGK 23 1 Q06203;D6RCC8 Q06203 PPAT Amidophosphoribosyltransferase 1 16568900.0 2352600.0 5139900.0 9076400.0 True False 3084281.382610812 4373046.955173279 8137261.194976619 1.0 1.4178495450604902 2.638300526292615 21.556502959343344 -6.952051094071525 0.5358583967114697 0.981525776198714 3.13058582728543 0.999352539989786 0.017686273227809433 0.08267254268270888 0.03263427182893166 0.019565463843074418 0.10100641569995972 1.1167318582825012e-07 6.952051094071525 2.1490600510867157 up YATTGK(ub)CELENCQPFVVETLHGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YATTGKCELENCQPFVVETLHGK 23 1 Q06203;D6RCC8 Q06203 PPAT Amidophosphoribosyltransferase 1 136692000.0 13156000.0 23926000.0 99610000.0 True False 19958613.83243231 19656218.36530877 79922039.83938609 1.0 0.9848488742924543 4.004388306241715 24.250508190171285 -6.90576859571983 0.9240535221664772 0.8935435456422927 4.361276114339042 0.98922478653218 0.14738746966543104 0.10728354087869611 0.15443121298041168 0.11819839879912249 0.31747001198955743 1.2423140710526543e-07 6.90576859571983 3.46773256869675 up YATTGK(ub)CELENCQPFVVETLHGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YATTGKCELENCQPFVVETLHGK 23 1 Q06203;D6RCC8 Q06203 PPAT Amidophosphoribosyltransferase 1 85922000.0 13156000.0 13203000.0 59563000.0 True False 17030701.34353023 12468241.443630228 48723145.16799018 1.0 0.7321038160514024 2.860900686659011 24.021634512263734 -6.875337016132156 1.1054274258023704 0.8422887260340357 2.9989282345369777 0.9697277681204621 0.164718896053449 0.13184305129783577 0.29790174634131755 0.11522271283251974 0.27563207050397953 1.3324870098464714e-07 6.875337016132156 2.156639508502942 up YAVLYQPLFDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAVLYQPLFDK 11 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 51753000.0 15635000.0 20109000.0 16009000.0 False True 20497636.40955538 17108815.584268074 14352542.24917153 1.0 0.8346726052908452 0.7002047437274674 24.288954225805362 -6.97347911586266 0.1538347727294444 1.1481765894075164 0.3831523927483598 0.9999983710929381 0.00015637490971629156 0.07518918252997667 0.004719615882441123 0.006606988289384199 0.01651924055392895 1.0629696976055604e-07 6.97347911586266 -0.7650241966591567 YAVLYQPLFDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YAVLYQPLFDK 11 0 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;F8VUX1;H0YH88;F8VXI6;P55209-3;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 59688000.0 15635000.0 25456000.0 18597000.0 False True 21415682.01998791 24331269.748265054 14204771.617237521 1.0 1.1361426512382813 0.663288313861766 24.352164287328254 -6.8297041488805315 1.3291535782025068 1.0727622456602173 0.6506340932515546 0.9052932694923441 0.06116309590381535 0.18117882317280098 0.6260848616553861 0.036130698636798346 0.08315126667480759 1.480116333179247e-07 6.8297041488805315 -0.42212815240866264 YAVLYQPLFDKR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAVLYQPLFDKR 12 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;H0YH88;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 42361000.0 16657000.0 14342000.0 11362000.0 False True 21837488.306617446 12202229.504678123 10186369.23199994 1.0 0.5587744036011899 0.4664624928001976 24.380303594829723 -13.999999999999998 0.21988360105256638 3.6611869386103817 0.4170295443862407 0.9994977755859242 0.005217670882230562 12.9964918771754 0.14855140234891806 15.016778934612983 0.05112701953053259 1.0000000000000041e-14 13.999999999999998 -3.244157394224141 YAVLYQPLFDKR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YAVLYQPLFDKR 12 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;H0YH88;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 35340500.0 12377000.0 6079500.0 16884000.0 False True 11984098.909827266 8507076.054173667 12461573.89085726 1.0 0.7098636383247512 1.0398423765209792 23.514618100341167 -6.674515939265725 1.9214369445145831 0.815529286432069 1.038535827176976 0.29915845883144765 0.12311717620542598 0.450838265099471 3.2130939507944745 0.051507170677429305 0.13680539977252187 2.115846029059752e-07 6.674515939265725 0.223006540744907 YAVLYQPLFDKR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YAVLYQPLFDKR 12 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;H0YH88;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 50305000.0 16657000.0 14725000.0 18923000.0 False True 22815543.03849942 14074400.810936656 14453777.13141829 1.0 0.6168777480854706 0.6335057248923984 24.443513656352614 -10.16131305985812 7.9848148989007885 1.0000000753440885 0.6251917364963855 0.9985260543005546 0.0067883431053010574 9.108601326608724e-09 9.567521949128381e-10 0.0065727863199704735 0.002190928316264415 6.897424258624715e-11 10.16131305985812 -0.37480833884770304 YAVLYQPLFDKR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAVLYQPLFDKR 12 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;H0YH88;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 31781300.0 12377000.0 7809300.0 11595000.0 False True 10292023.894068692 7767229.750875312 14019460.89077735 1.0 0.7546843877181025 1.3621675420766157 23.295023375775443 -6.79707206400208 1.4677116935954004 0.8641440884040457 1.3699727646649682 0.8235152267419776 0.10482720646819461 0.22495365088438732 0.9569559505948663 0.05619466527728686 0.1309353131966486 1.595614359398346e-07 6.79707206400208 0.5058286762609225 YAVLYQPLFDKR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YAVLYQPLFDKR 12 1 P55209;P55209-2;H0YIV4;F5H4R6;F8W0J6;F8VY35;F8VV59;H0YHC3;F8W020;F8W118;B7Z9C2;F8W543;H0YH88;F8VVB5;F8VRJ2 P55209 NAP1L1 Nucleosome assembly protein 1-like 1 0 32191800.0 11121000.0 11510000.0 9560800.0 False True 14396353.727683185 10869458.381896835 7820832.50209226 1.0 0.7550146785429164 0.5432509265907619 23.779200119968646 -6.972827066853985 0.17815651365541205 1.167759054722916 0.12479054980635385 0.999996864409055 0.00033042892544213304 0.07539560355679678 0.005606873182381687 0.008289325391803663 0.023899286133502312 1.0645668372028287e-07 6.972827066853985 -1.042968504916562 YAVNVALQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAVNVALQK 9 0 Q9NVI1 Q9NVI1 FANCI Fanconi anemia group I protein 0 14133800.0 4135300.0 3190600.0 6807900.0 False True 5421418.346302164 2714574.91686139 6103483.813988071 1.0 0.500713050250576 1.125809414459065 22.370238906786202 -6.694023104954455 1.8525882301581147 0.6881546272275245 1.123730482188477 0.38908969089057366 0.21099557770003494 0.4080875827325601 2.7186323400407164 0.09101771248418476 0.23578080213282998 2.0229115546475777e-07 6.694023104954455 0.4355758549609525 YAVNVALQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YAVNVALQK 9 0 Q9NVI1 Q9NVI1 FANCI Fanconi anemia group I protein 0 4551000.0 1486600.0 0.0 3064400.0 False True 1439408.6967236982 0.0 2261741.70997056 1.0 0.0 1.5712991835596175 20.457044849395018 -6.734743559481646 1.7059562255887675 0.40143760137360185 1.571212374627526 0.5812249488734058 0.42023851736565826 0.32735486146934467 1.8684640318413626 0.19504869418880147 0.4814186850833117 1.8418592543354534e-07 6.734743559481646 1.169774773253924 YAVNVALQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YAVNVALQK 9 0 Q9NVI1 Q9NVI1 FANCI Fanconi anemia group I protein 0 9922000.0 4135300.0 3037900.0 2748800.0 False True 5664232.162280523 2903675.5330081107 2099590.053313039 1.0 0.5126335661776684 0.370675140629777 22.433448968309094 -13.999999999999998 0.1729404067024392 3.477294521294668 0.24929243772759277 0.9995083766890804 0.005975762441748158 12.121504477032232 0.13174336929941868 10.077144657844288 0.11271052265146901 1.0000000000000041e-14 13.999999999999998 -3.228002083567075 YAVNVALQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAVNVALQK 9 0 Q9NVI1 Q9NVI1 FANCI Fanconi anemia group I protein 0 4440500.0 1486600.0 1104800.0 1849100.0 False True 1236173.7675464584 1098848.2231143697 2235738.260727589 1.0 0.8889108084661506 1.808595457550481 20.237450124829294 -6.876710016123053 1.097943756445448 0.9337289565219511 1.8698065297562352 0.9709351694801683 0.0698773955183531 0.1305861772299691 0.29021398078578964 0.04916141933300276 0.11795629848603068 1.328281071639652e-07 6.876710016123053 0.9360775732342841 YAVSMAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAVSMAR 7 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 3489100.0 684400.0 1423900.0 1380800.0 False True 897255.0277390283 1211459.6703187285 1237928.0615688725 1.0 1.3501843209187214 1.3796836164722288 19.77515857659501 -12.079782970390443 0.38694184414765564 3.536430450375952e-10 1.382200584269014 0.9997166036940398 0.002903125672712086 5.877910006631838 0.1989278201644147 4.763640150905323 0.007829410316694773 8.321795315749278e-13 12.079782970390443 1.3822005839153708 YAVSMAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YAVSMAR 7 0 P13797;A0A0A0MSQ0;P13797-2;P13797-3 P13797 PLS3 Plastin-3 0 2478520.0 684400.0 867910.0 926210.0 False True 937441.1752145656 829562.866405435 707458.2738937237 1.0 0.8849225832389548 0.7546695116435413 19.838368638117903 -6.96951459989826 0.269528368852445 1.032565662846826 0.6031131057732646 0.999978341722199 0.00046637082143855576 0.0764605287649254 0.009592393643222898 0.0025606466205335262 0.012122133450380523 1.0727175851372641e-07 6.96951459989826 -0.42945255707356145 YAVWFGGSMLASTPEFYQVCHTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YAVWFGGSMLASTPEFYQVCHTK 23 0 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 0 235981000.0 64192000.0 74398000.0 97391000.0 False True 97383957.06381081 61121095.62577285 78141626.16200839 1.0 0.6276300272510313 0.8024075886627415 26.537180787948063 -10.053873662201427 4.791432586460858 1.0000083467147698 0.7150188079520108 0.7799714936742008 0.07135264067455212 6.362124795454854e-06 1.2563451215690056e-06 0.06908892063778753 0.02302896575098807 8.83336828849228e-11 10.053873662201427 -0.284989538762759 YAVWFGGSMLASTPEFYQVCHTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YAVWFGGSMLASTPEFYQVCHTK 23 0 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 0 146939000.0 64192000.0 37693000.0 45054000.0 False True 83097809.4134914 35595351.41519003 36854634.29307844 1.0 0.4283548708013346 0.4435090955249042 26.308307110040513 -9.995690218844143 6.212386670551937 1.000000325215109 0.4359319831978454 0.9994589578482088 0.006186686336794591 2.786160598359821e-08 4.511651130267347e-09 0.0059902366794153585 0.001996744429204338 1.0099730404200975e-10 9.995690218844143 -0.5640683420172636 YAWASEEDDASSLTADNLEK(ub)FGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YAWASEEDDASSLTADNLEKFGK 23 1 Q9UPN4-3;Q9UPN4-2 Q9UPN4-3 CEP131 Centrosomal protein of 131 kDa 1 22063300.0 11491000.0 7672300.0 2900000.0 True False 9555275.63761359 7630967.797067687 3506376.5919149886 1.0 0.7986130475429701 0.36695713707225913 23.18786606003424 -6.95866824821098 0.4538163400194027 1.013389671101589 0.13495899503490397 0.9997175625606972 0.004438030158324249 0.08018036665385689 0.02291562639928277 0.005803324186649211 0.035685845098628974 1.0998456761320444e-07 6.95866824821098 -0.8784306760666851 down YAYSK(ub)QPEVCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YAYSKQPEVCR 11 1 A0A087X0Q9;Q9BVL4 A0A087X0Q9 SELO Selenoprotein O 1 2636330.0 546690.0 921840.0 1167800.0 True False 716715.8841534911 784305.0653041753 1046967.2583285972 1.0 1.0943040089456275 1.460784226325839 19.45104180290998 -6.945539098046555 0.6058509437174319 0.9959195040094049 1.5781181640603363 0.9988030011051167 0.006876372243215495 0.08532817904980511 0.04376915421820758 0.007017411105780101 0.030858127851339266 1.1336027791311348e-07 6.945539098046555 0.5821986600509315 YCALLLPLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YCALLLPLLK 10 0 A0A3B3IUB1;Q13144 A0A3B3IUB1 EIF2B5 Translation initiation factor eIF-2B subunit epsilon 0 6817700.0 1925400.0 3026100.0 1866200.0 False True 2524218.0456001256 2574617.6756454143 1673103.5258544527 1.0 1.0199664328258562 0.6628205232787951 21.267405107108562 -6.893664080562626 1.0004325433500085 1.017538415412648 0.6298008195614843 0.9831425158530113 0.021274589712198623 0.11622143336179305 0.20487403238931065 0.01611978760844009 0.040755840784978896 1.2774264945739062e-07 6.893664080562626 -0.38773759585116363 YCALLLPLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YCALLLPLLK 10 0 A0A3B3IUB1;Q13144 A0A3B3IUB1 EIF2B5 Translation initiation factor eIF-2B subunit epsilon 0 9016800.0 1925400.0 3071500.0 4019900.0 False True 2637272.4119785586 2935790.9739077655 3070482.412439275 1.0 1.1131921604204889 1.1642644114021234 21.330615168631454 -13.999999999985768 0.1073997042733482 0.45114404351458226 1.2615618536177204 0.9997562747494462 0.001071579161270359 12.028465158208498 0.09901032264667867 1.4388078320029063 0.08648521376641892 1.0000000000327709e-14 13.999999999985768 0.8104178101031382 YCANAFK(ub)LHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YCANAFKLHR 10 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 5638100.0 1525700.0 2154300.0 1958100.0 True False 2000207.4748998168 1832886.8373956291 1755494.5954214989 1.0 0.9163483590558184 0.8776562518892823 20.931718223066497 -13.999999195396772 0.10332400702942222 1.4093944212321483 0.7993338242306126 0.9997769597048995 0.000762511978798242 12.05591633527909 0.09638258793682562 1.0439828299794025 0.06973234091430995 1.0000018526691159e-14 13.999999195396772 -0.6100605970015357 YCANAFK(ub)LHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YCANAFKLHR 10 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 3560010.0 1210300.0 681810.0 1667900.0 True False 1171879.6889847254 954060.2885921794 1231026.9540725416 1.0 0.814128188721099 1.0504721309224663 20.160393032416515 -6.697008735644479 1.8417593387617246 0.8842434662617275 1.0497260885915651 0.4033200036519393 0.07850260197929433 0.401762872721996 2.6474105899776434 0.034033439398633646 0.08784242500723181 2.0090524009876826e-07 6.697008735644479 0.16548262232983768 YCANAFK(ub)LHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YCANAFKLHR 10 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 27449400.0 5730000.0 5736400.0 15983000.0 True False 8692828.919111982 4712694.601302232 12823953.044402251 1.0 0.5421358967436872 1.4752335705362398 23.05139432098015 -6.773244890465332 1.5617875128905812 0.7384807882347402 1.4811735127793637 0.742941438018731 0.1931490596931749 0.2611927831180112 1.257714308819484 0.09745129392145556 0.23131426132535465 1.6856022780341745e-07 6.773244890465332 0.7426927245446235 YCANAFK(ub)LHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YCANAFKLHR 10 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 6099300.0 1525700.0 1558900.0 3014700.0 True False 2089792.5204922003 1490022.6434070712 2302689.9496954377 1.0 0.7130002757671524 1.101874912038203 20.99492828458939 -6.708953651360127 1.7986945769779887 0.8233748921601182 1.100943529027832 0.4602590759265194 0.12095960613856056 0.3771730934837821 2.3779998875586017 0.053526272926863565 0.13616692602512112 1.9545480373094674e-07 6.708953651360127 0.2775686368677138 YCANAFK(ub)LHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YCANAFKLHR 10 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 4970300.0 1210300.0 1161700.0 2598300.0 True False 1006418.0753810571 1155441.6915206036 3141592.516818173 1.0 1.1480732707261068 3.1215581214881114 19.94079830785079 -6.921935631969481 0.8102400445145678 0.9594192305829082 3.4544155814360917 0.9947019446241172 0.07039317268409788 0.09704626600550256 0.09981013763771415 0.06128100458372905 0.1871049286832711 1.1969179167981702e-07 6.921935631969481 2.4949963508531834 up YCANAFK(ub)LHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YCANAFKLHR 10 1 P61221;D6R9I9;D6RGF4;H0Y990 P61221 ABCE1 ATP-binding cassette sub-family E member 1 1 22878700.0 5730000.0 5665700.0 11483000.0 True False 7417597.955186099 5350398.814449427 9393211.82552981 1.0 0.7213115144247787 1.2663414601707332 22.8225206430726 -6.76773793590683 1.5833069175344345 0.8396850815702545 1.2691329336484185 0.7217270928949832 0.11738628129534644 0.27012216456152827 1.336077057320944 0.05845312583604409 0.1394224670184011 1.7071121922275193e-07 6.76773793590683 0.42944785207816405 YCAQDAFFQVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YCAQDAFFQVK 11 0 Q13011;M0R248 Q13011 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 14792000.0 4180600.0 4672900.0 5938500.0 False True 5480807.084987991 3975721.5348215345 5324040.986114383 1.0 0.7253897962785614 0.9713972602131915 22.385956924512605 -10.304349048788445 7.456538233011535 1.0000009853030196 0.8483935284365987 0.33615744692347393 0.10043212659266319 1.6451051801653835e-06 1.535231572963705e-07 0.09724362018361532 0.03241432947646496 4.9619336332831975e-11 10.304349048788445 -0.15160745686642096 YCAQDAFFQVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YCAQDAFFQVK 11 0 Q13011;M0R248 Q13011 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 13699000.0 4180600.0 3783900.0 5734500.0 False True 5726280.796466996 3616714.7863160074 4380129.2057347195 1.0 0.6315992726985115 0.7649169437232582 22.449166986035497 -10.223897911656696 5.518209913054735 1.0000157376936423 0.6982581091409974 0.8722896214406576 0.05442671128454243 1.0538417569094187e-05 1.482188114369125e-06 0.052701182602471024 0.01756614553281312 5.971756464320804e-11 10.223897911656696 -0.3017576285526449 YCDLECSHTCNYK(ub)TR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YCDLECSHTCNYKTR 15 1 Q16659 Q16659 MAPK6 Mitogen-activated protein kinase 6 1 38416200.0 2033300.0 23193800.0 13189100.0 True False 3084664.754141426 19054685.17601347 10582268.604012107 1.0 6.177230491719052 3.4306057375617582 21.5566822730201 -9.571289882398135 8.990800061252544 1.0000002868280946 4.803918114640408 0.7188975607643647 1.121304860430467 0.0 0.0 1.0856987464389796 0.3618995875390489 2.6835526329973174e-10 9.571289882398135 3.803917827812313 YCDLECSHTCNYK(ub)TR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YCDLECSHTCNYKTR 15 1 Q16659 Q16659 MAPK6 Mitogen-activated protein kinase 6 1 8107810.0 1480100.0 1341700.0 5286010.0 True False 2027332.968198536 1282419.2575914229 4037563.3067932334 1.0 0.6325646934706367 1.9915639759861274 20.951151625133743 -6.834692670507031 1.3066620409327703 0.8042036178034367 2.031806019460625 0.9149616016961661 0.1673805505172617 0.17509186177305106 0.5829553316760896 0.10052016527500367 0.23137130895755442 1.463212253705522e-07 6.834692670507031 1.2276024016571885 YCDLECSHTCNYK(ub)TR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YCDLECSHTCNYKTR 15 1 Q16659 Q16659 MAPK6 Mitogen-activated protein kinase 6 1 37406900.0 2033300.0 17876300.0 17497300.0 True False 2632146.932335057 16881468.190469388 14312970.937459096 1.0 6.413573643281885 5.437755302194178 21.32780859511255 -10.26167439797936 5.444553627783129 0.9995294438140339 5.925664472738309 0.9714062919462626 0.39837616955331556 0.0022755938819207853 0.0003085884728801108 0.3857492320109942 0.12857535585034965 5.474262289545547e-11 10.26167439797936 4.926135028924275 YCEPVVK(ub)GEASER ddPTM_RPMI8226_Bortezomib_1h_R1 1 YCEPVVKGEASER 13 1 O43913;O43913-2 O43913 ORC5 Origin recognition complex subunit 5 1 2109120.0 569840.0 774480.0 764800.0 True False 747065.7583384103 658930.6028993956 685665.8324796308 1.0 0.8820249028210838 0.917811885803276 19.510875712167927 -10.207444472261692 5.309311668883438 1.0000062005419936 0.8999183954371023 0.9124948896618434 0.014609974623417215 1.0723772514036354e-06 1.600801432461783e-07 0.01414692343993238 0.004715349033739422 6.202339400476524e-11 10.207444472261692 -0.10008780510489135 YCEPVVK(ub)GEASER ddPTM_RPMI8226_Bortezomib_8h_R1 1 YCEPVVKGEASER 13 1 O43913;O43913-2 O43913 ORC5 Origin recognition complex subunit 5 1 23774700.0 2069900.0 2856800.0 18848000.0 True False 3140189.629959839 2346981.7197197215 15122684.538628126 1.0 0.7474012707155325 4.815850735365156 21.58242025262645 -6.892116196160415 1.009797196445111 0.7923576878248897 5.180612179655746 0.9822179853764791 0.24819042517361609 0.11744228033481492 0.21196084834105347 0.18673702219421867 0.46922106737378905 1.2819875390180535e-07 6.892116196160415 4.388254491830857 up YCEPVVK(ub)GEASER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YCEPVVKGEASER 13 1 O43913;O43913-2 O43913 ORC5 Origin recognition complex subunit 5 1 3019840.0 569840.0 1027700.0 1422300.0 True False 780525.2473469728 982292.8158505658 1086382.033187985 1.0 1.2585022959723682 1.3918602080850402 19.57408577369082 -12.511675480699388 0.09712901123903507 5.887788486827706e-18 1.7136488604936058 0.9998498748932819 0.0019931500640182434 7.083290358566738 0.07744930713889474 1.6704922161542695 0.254268560580424 3.0783962357219187e-13 12.511675480699388 1.7136488604936058 YCEPVVK(ub)GEASER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YCEPVVKGEASER 13 1 O43913;O43913-2 O43913 ORC5 Origin recognition complex subunit 5 1 30052000.0 2069900.0 2661100.0 25321000.0 True False 2679526.353828917 2513007.4457050976 20712837.815400187 1.0 0.9378550959628101 7.730036984261236 21.353546574718898 -6.904834214868625 0.9301871675114091 0.7538255318588094 8.517362322339224 0.9888220253002593 0.3369822521110569 0.10793429908011623 0.15802614609166832 0.26903074022276197 0.7185843269158815 1.2449897764629107e-07 6.904834214868625 7.763536790480415 up YCFQITSFDGKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YCFQITSFDGKK 12 1 Q9UKG1 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 0 13842200.0 4526100.0 2398800.0 6917300.0 False True 5933760.93081475 2040908.3904491623 6201564.15142697 1.0 0.34394853689680593 1.0451321217242653 22.500515371626694 -11.884557431942333 14.298703188061658 0.9270858822999908 0.7250862963821036 0.0 0.3282645612212309 0.0 0.0 0.0 0.09529820020864666 1.3044954482315983e-12 11.884557431942333 -0.20199958591788714 YCFQITSFDGKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YCFQITSFDGKK 12 1 Q9UKG1 Q9UKG1 APPL1 DCC-interacting protein 13-alpha 0 13995400.0 4526100.0 6171900.0 3297400.0 False True 6199521.483253424 5899205.050256023 2518622.032084692 1.0 0.9515581268959812 0.4062607152645842 22.563725433149585 -6.924337057931286 0.7918929881396041 1.0102572089306787 0.30891144221167716 0.995303373417243 0.018448860006309315 0.09568666127298214 0.0928788163546427 0.01627232223026121 0.05096231253142034 1.1903178383358346e-07 6.924337057931286 -0.7013457667190015 down YCIFANFSVTGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YCIFANFSVTGGK 13 0 P61964;Q86VZ2 P61964 WDR5;WDR5B WD repeat-containing protein 5;WD repeat-containing protein 5B 0 138758000.0 36841000.0 42162000.0 59755000.0 False True 55890490.437871635 34637861.68679043 47944398.0584531 1.0 0.6197451733814034 0.8578274708780471 25.73609949888626 -10.437878553430707 5.9206926633921215 1.000122700855126 0.7387863221297252 0.6161235578088439 0.09719669094271403 0.00015749843906568832 1.4953107218925054e-05 0.0941542336227886 0.031370097110633335 3.64855961369032e-11 10.437878553430707 -0.2613363787254007 YCIFANFSVTGGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YCIFANFSVTGGK 13 0 P61964;Q86VZ2 P61964 WDR5;WDR5B WD repeat-containing protein 5;WD repeat-containing protein 5B 0 112966000.0 36841000.0 33117000.0 43008000.0 False True 47691400.744679056 31274009.83781735 35180985.29934565 1.0 0.6557578378803772 0.7376798489876774 25.50722582097871 -10.262980168985836 5.507200279068339 1.000026480708985 0.6967188434340166 0.9481160388942452 0.03344452098595953 1.0874895704037165e-05 1.4553917569387757e-06 0.03238534209494839 0.010794172733369297 5.4578278238184656e-11 10.262980168985836 -0.30330763727496834 YCK(ub)NKPYPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YCKNKPYPK 9 2 P27635;X1WI28;A0A087WV22;A6QRI9;Q96L21 P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 9038200.0 1646700.0 2515600.0 4875900.0 True False 2158839.646665483 2140282.285732001 4371388.6409354415 1.0 0.9914040114270899 2.0248788036144485 21.04182465680131 -6.905022622044519 0.9289465386084798 0.9627494408987577 2.145148154000397 0.9889041523721486 0.05110640476122729 0.10780307859183778 0.1572948223903492 0.04083786159965987 0.10920028294093252 1.2444497877110018e-07 6.905022622044519 1.1823987131016396 up YCK(ub)NKPYPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YCKNKPYPK 9 2 P27635;X1WI28;A0A087WV22;A6QRI9;Q96L21 P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 5566400.0 2280700.0 2031800.0 1253900.0 True False 2208300.4268920617 2843108.335697028 925465.9738063192 1.0 1.2874644686359038 0.41908517633572623 21.074505025363948 -6.817473940311921 1.3826544684009983 1.1553496280599864 0.4011170029791249 0.8785049561831334 0.1258999182600091 0.19678002006201678 0.7398492108906604 0.07156520665070142 0.16507680261011368 1.522390480646633e-07 6.817473940311921 -0.7542326250808615 down YCK(ub)NKPYPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YCKNKPYPK 9 2 P27635;X1WI28;A0A087WV22;A6QRI9;Q96L21 P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 4916820.0 344600.0 839420.0 3732800.0 True False 522783.39363455254 689618.9425816048 2995010.443855639 1.0 1.3191293965693127 5.728970124765051 18.995853788673468 -6.921458862950762 0.8138301793458916 0.9077216132817476 6.464528112247776 0.9945767287482172 0.1589194424051102 0.0973210231047077 0.10122085100952086 0.1379938349551405 0.4193043829876912 1.1982326162731058e-07 6.921458862950762 5.556806498966028 up YCK(ub)NKPYPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YCKNKPYPK 9 2 P27635;X1WI28;A0A087WV22;A6QRI9;Q96L21 P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 13974300.0 1646700.0 2533300.0 9794300.0 True False 2255529.4903942486 2421370.429497166 7481088.059940295 1.0 1.0735263891734486 3.3167768773587 21.1050347183242 -6.913872616256641 0.8689414613460583 0.9387591381483195 3.632046083402204 0.9923028867980136 0.09433317086743456 0.10191266350999323 0.12528647331646844 0.07874221991905946 0.22366534935078397 1.2193471955317358e-07 6.913872616256641 2.6932869452538846 up YCK(ub)NKPYPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YCKNKPYPK 9 2 P27635;X1WI28;A0A087WV22;A6QRI9;Q96L21 P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 6917700.0 2280700.0 590900.0 4046100.0 True False 1896503.1021412674 587716.7044155337 4892120.802947325 1.0 0.309894934393709 2.5795480099261754 20.854910300798224 -6.825124202523392 1.3495606814105023 0.6298403649144575 2.634763442347704 0.8957751382025677 0.3066976102465288 0.18689709314444258 0.6674180009859098 0.17851822894418887 0.4110029087234316 1.495807813510686e-07 6.825124202523392 2.0049230774332467 up YCK(ub)NKPYPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YCKNKPYPK 9 2 P27635;X1WI28;A0A087WV22;A6QRI9;Q96L21 P27635 RPL10;RPL10L 60S ribosomal protein L10;60S ribosomal protein L10-like 1 3672580.0 344600.0 945080.0 2382900.0 True False 446091.493081523 892485.4672079126 1949236.6506187378 1.0 2.0006780695206206 4.3695893798685725 18.766980110765918 -6.95662019397785 0.4807136001629796 0.9435195185110039 5.525631782130839 0.9996235511021226 0.02741399404503929 0.0809314327516643 0.025766698633025404 0.03344944900269147 0.19541011246299536 1.1050445983837985e-07 6.95662019397785 4.582112263619835 YCLSILTSHVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YCLSILTSHVK 11 0 O95163;F5H2T0 O95163 IKBKAP Elongator complex protein 1 0 18515200.0 10361600.0 5295800.0 2857800.0 False True 13584157.941877132 4505687.282866718 2562102.2699533054 1.0 0.33168690338740997 0.18860957601610898 23.695421802408163 -13.999999999999998 0.21662844632749137 4.97430781362911 0.10956013048206258 0.9994947473720077 0.007948761839034648 12.910088413863576 0.14747290131457802 21.9105192251078 0.08098110835859802 1.0000000000000041e-14 13.999999999999998 -4.864747683147048 YCLSILTSHVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YCLSILTSHVK 11 0 O95163;F5H2T0 O95163 IKBKAP Elongator complex protein 1 0 31271100.0 10361600.0 7051900.0 13857600.0 False True 14192563.531711332 6740323.740485165 10584720.28623063 1.0 0.47491939884044476 0.7457934052985232 23.758631863931054 -10.063459524928136 5.721342396888244 1.0000017076497136 0.6103564020694137 0.7339661639512298 0.11058385006785672 2.408781994376302e-06 3.9432356667201817e-07 0.10707282144139216 0.03569078413932267 8.640531843533807e-11 10.063459524928136 -0.38964530558029997 YCNTWPVAISMLASK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YCNTWPVAISMLASK 15 0 Q00796 Q00796 SORD Sorbitol dehydrogenase 0 4766400.0 1252400.0 1928800.0 1585200.0 False True 1641908.5282588536 1641030.5584035148 1421178.7103121197 1.0 0.9994652748065875 0.8655650944326327 20.646942325244268 -6.907775827359732 0.9107476801351145 1.0044430468669543 0.849059379247975 0.9900548138232862 0.00630739566460192 0.10590724274518842 0.14688126694437686 0.005107820744797706 0.01389179897999235 1.2365855652436187e-07 6.907775827359732 -0.15538366761897926 YCNTWPVAISMLASK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YCNTWPVAISMLASK 15 0 Q00796 Q00796 SORD Sorbitol dehydrogenase 0 6826500.0 1252400.0 2318500.0 3255600.0 False True 1715446.1248374083 2216061.003745778 2486694.331186669 1.0 1.2918278059917612 1.449590456489772 20.71015238676716 -11.706906847851313 0.09634899685842609 4.954973427906025e-22 1.855461245657899 0.9998793465796919 0.0020457484249752815 4.9379976230175044 0.0677518228181674 1.326318874414895 0.29238672223570816 1.963781444618961e-12 11.706906847851313 1.855461245657899 YCPNSVLVIIDVKPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YCPNSVLVIIDVKPK 15 1 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 6514400.0 2307000.0 4207400.0 0.0 False True 3024499.341019776 3579672.3203167487 0.0 1.0 1.1835586378768341 0.0 21.52826491567594 -6.922127329347343 1.2550526215226212 1.0969822883568032 1.6139949424949106e-18 0.960269196767788 0.10366872012742807 0.12111641116719501 0.38161642003660745 0.06799435283948481 0.13250629290941052 1.1963897143813965e-07 6.922127329347343 -1.0969822883568032 down YCPNSVLVIIDVKPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YCPNSVLVIIDVKPK 15 1 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 131705000.0 24121000.0 61704000.0 45880000.0 False True 36593320.48130889 50692439.10444754 36811797.8900816 1.0 1.3852921363159758 1.0059704177128255 25.12507699611069 -9.705331440749504 11.005490049435702 0.9999994837338716 1.1956312768568027 0.26180191138638664 0.1548574431558375 0.0 0.0 0.14994007459457548 0.04998002486485849 1.9709180154641461e-10 9.705331440749504 0.1956317931229311 YCPNSVLVIIDVKPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YCPNSVLVIIDVKPK 15 1 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 13376500.0 2307000.0 4372500.0 6697000.0 False True 3159960.2443307997 4179308.4920760915 5115306.529044457 1.0 1.3225826177952957 1.6187882547641832 21.591474977198832 -6.972145907962968 0.20040754686037698 0.8246157718829167 2.124936947389145 0.9999946377860318 0.0005851252617757743 0.0756123030449759 0.0064741203340634825 0.009584648536614697 0.03141349274771068 1.0662378419186932e-07 6.972145907962968 1.300321175506228 YCPNSVLVIIDVKPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YCPNSVLVIIDVKPK 15 1 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 12424600.0 6904200.0 1193100.0 4327300.0 False True 5741148.207920259 1186672.5334881935 5232118.422825422 1.0 0.20669602847930446 0.9113365886648598 22.452907868631613 -10.86885690050232 10.191148923903679 1.020319998485883 0.5590163085727021 0.3430621483975058 0.28766830408725175 0.1132047185352058 0.001456753615954606 0.23741123497052882 0.09284454591347147 1.352518142845974e-11 10.86885690050232 -0.46130368991318094 YCPNSVLVIIDVKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YCPNSVLVIIDVKPK 15 1 P51665;H3BNT7;H3BTM8 P51665 PSMD7 26S proteasome non-ATPase regulatory subunit 7 0 90778000.0 24121000.0 35682000.0 30975000.0 False True 31225109.995993674 33696265.33300112 25337867.830339275 1.0 1.0791400042249493 0.8114580808070889 24.89620331820314 -6.827507270549344 1.338917032890884 1.0423670188579404 0.8046104768978174 0.9008065981373422 0.035363132082030097 0.1839137281850708 0.6456678698755577 0.020741972700903902 0.04774303531427279 1.487622469496196e-07 6.827507270549344 -0.23775654196012297 YCPSIESK(ub)VLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YCPSIESKVLR 11 1 Q9Y2Z2-2;Q9Y2Z2-4;Q9Y2Z2-6;Q9Y2Z2;Q9Y2Z2-5 Q9Y2Z2-2 MTO1 Protein MTO1 homolog, mitochondrial 1 23361200.0 2362800.0 6992400.0 14006000.0 True False 3097653.6813877514 5949161.176161718 12556793.475038838 1.0 1.9205378612551964 4.053646652137493 21.56274442872831 -6.957067052745756 0.4749666597143089 0.9462939578321538 5.1160728976518195 0.9996454826916559 0.024081597869083447 0.0807659384988262 0.025132271399929164 0.029776011842242753 0.17600263946589512 1.1039081692255411e-07 6.957067052745756 4.169778939819666 YCQVIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YCQVIR 6 0 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2 P39023 RPL3 60S ribosomal protein L3 0 10298380.0 624480.0 5477400.0 4196500.0 False True 818699.3274729234 4660193.270737975 3762286.4356704624 1.0 5.692191399646776 4.595443417894943 19.642974184657188 -9.816401239867409 6.969025278095342 0.9999999766198927 5.143817408770962 0.9500844413425916 0.44774548862024927 1.6320610508073214e-07 2.9662992359757508e-08 0.4335277310314699 0.14450923506375563 1.5261554085978432e-10 9.816401239867409 4.14381743215107 YCQVIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YCQVIR 6 0 P39023;G5E9G0;B5MCW2;H7C422;H7C3M2 P39023 RPL3 60S ribosomal protein L3 0 10059580.0 624480.0 4190700.0 5244400.0 False True 855367.1319374522 4005541.0172082987 4005780.7318083835 1.0 4.682832514426331 4.683112762042979 19.70618424618008 YCSQVESASK(ub)HLDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YCSQVESASKHLDR 14 1 A0A0A0MR07;P15498;F5H5P4;Q96D37;P15498-2 A0A0A0MR07 VAV1 Proto-oncogene vav 1 12936610.0 897610.0 1560000.0 10479000.0 True False 1161973.8395383223 1473184.6286497908 8571929.52361986 1.0 1.2678294282727736 7.3770417473647045 20.148146157865945 -6.916087242072892 0.8532307090255095 0.8452766136347905 8.278727586723809 0.9930234313341632 0.24598938862857647 0.10052929972122032 0.1179444922026415 0.20766505273650213 0.6005865148906533 1.2131451266068454e-07 6.916087242072892 7.433450973089019 up YCTTYQSK(ub)GQTLTLTQQQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YCTTYQSKGQTLTLTQQQR 19 1 B4E2Q0;P98194-2;P98194;P98194-5;P98194-8;P98194-9;P98194-6;P98194-7;H0Y9V7;P98194-4;P98194-3;H0Y9S7;H0Y8X9 B4E2Q0 ATP2C1 Calcium-transporting ATPase;Calcium-transporting ATPase type 2C member 1 1 73657000.0 24809000.0 25945000.0 22903000.0 True False 32524839.250697788 22074107.13281789 20533217.261089135 1.0 0.6786845881903725 0.6313088007236997 24.955038590861164 -13.999999999742101 0.26957871413866474 3.47442892938747 0.6155187465724493 0.9995824223510273 0.0033468363517924165 14.862322346180713 0.1643563694570106 20.149666306123294 0.01971756915496757 1.0000000005938335e-14 13.999999999742101 -2.8589101828150207 YCTTYQSK(ub)GQTLTLTQQQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YCTTYQSKGQTLTLTQQQR 19 1 B4E2Q0;P98194-2;P98194;P98194-5;P98194-8;P98194-9;P98194-6;P98194-7;H0Y9V7;P98194-4;P98194-3;H0Y9S7;H0Y8X9 B4E2Q0 ATP2C1 Calcium-transporting ATPase;Calcium-transporting ATPase type 2C member 1 1 42451900.0 21171000.0 12794000.0 8486900.0 True False 20498938.193419505 17902710.919828586 6263926.288457498 1.0 0.8733482071561955 0.30557320722437814 24.289045846978297 -6.942266401901369 0.6381321207092633 1.0062083304393268 0.14168380632580582 0.9984459234933869 0.0119039371027085 0.08674777185884415 0.05001450799445392 0.01179719885737075 0.04840036818650904 1.1421774932829012e-07 6.942266401901369 -0.864524524113521 down YCTTYQSK(ub)GQTLTLTQQQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YCTTYQSKGQTLTLTQQQR 19 1 B4E2Q0;P98194-2;P98194;P98194-5;P98194-8;P98194-9;P98194-6;P98194-7;H0Y9V7;P98194-4;P98194-3;H0Y9S7;H0Y8X9 B4E2Q0 ATP2C1 Calcium-transporting ATPase;Calcium-transporting ATPase type 2C member 1 1 107592000.0 29875000.0 25620000.0 52097000.0 True False 45322559.155055895 21047910.830026343 41800005.1150737 1.0 0.46440252321185116 0.9222781302368439 25.43372598997872 -10.187862598818173 7.823033836748844 1.0000001359184139 0.693340326724349 0.3742479012152852 0.18692693381305683 4.431496335239749e-07 4.619634462632141e-08 0.1809913063122096 0.06033040846796546 6.488396796225975e-11 10.187862598818173 -0.3066598091940649 YCTTYQSK(ub)GQTLTLTQQQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YCTTYQSKGQTLTLTQQQR 19 1 B4E2Q0;P98194-2;P98194;P98194-5;P98194-8;P98194-9;P98194-6;P98194-7;H0Y9V7;P98194-4;P98194-3;H0Y9S7;H0Y8X9 B4E2Q0 ATP2C1 Calcium-transporting ATPase;Calcium-transporting ATPase type 2C member 1 1 84289000.0 24809000.0 32040000.0 27440000.0 True False 33981557.73801603 30624366.857888617 20959237.14453936 1.0 0.9012055037026263 0.6167827062586871 25.018248652384056 -6.952372872336239 0.5321558524642354 1.004417483163114 0.5006113187121426 0.999374583590416 0.004062616993873511 0.08254666982148873 0.032125524971278775 0.004518178521756325 0.023526971398218632 1.1159047537119666e-07 6.952372872336239 -0.5038061644509715 YCTTYQSK(ub)GQTLTLTQQQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YCTTYQSKGQTLTLTQQQR 19 1 B4E2Q0;P98194-2;P98194;P98194-5;P98194-8;P98194-9;P98194-6;P98194-7;H0Y9V7;P98194-4;P98194-3;H0Y9S7;H0Y8X9 B4E2Q0 ATP2C1 Calcium-transporting ATPase;Calcium-transporting ATPase type 2C member 1 1 48766000.0 21171000.0 10978000.0 16617000.0 True False 17604624.534324024 10918859.335037615 20091537.871672887 1.0 0.6202267656290503 1.1412647757695762 24.069451122412573 -6.711246801088224 1.790671466830823 0.7668294584716477 1.1400933824200876 0.47113688631830464 0.1600023083872269 0.37253654888076393 2.329295957341558 0.07108496601348004 0.18032272981382158 1.944254885470261e-07 6.711246801088224 0.3732639239484399 YCTTYQSK(ub)GQTLTLTQQQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YCTTYQSKGQTLTLTQQQR 19 1 B4E2Q0;P98194-2;P98194;P98194-5;P98194-8;P98194-9;P98194-6;P98194-7;H0Y9V7;P98194-4;P98194-3;H0Y9S7;H0Y8X9 B4E2Q0 ATP2C1 Calcium-transporting ATPase;Calcium-transporting ATPase type 2C member 1 1 72290000.0 29875000.0 20396000.0 22019000.0 True False 38673776.42429049 19260944.67047508 18011767.93401905 1.0 0.4980363039586052 0.46573594821492775 25.204852312071168 -13.999999999999998 0.3900056492256631 8.93683481859053 0.4633818649028275 0.9998231476905349 0.0032527875054776194 25.35035720202777 0.20470349924237866 169.61223696937293 0.008501103200137883 1.0000000000000041e-14 13.999999999999998 -8.473452953687703 YCYLQNEVFGLFQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YCYLQNEVFGLFQK 14 0 P15924;P15924-3;P15924-2 P15924 DSP Desmoplakin 0 7804100.0 1918200.0 1164000.0 4721900.0 False True 2627410.3774058735 1112570.6311667394 3606684.470583097 1.0 0.42344760481048876 1.3727145563549505 21.325210123130166 -6.742291647630883 1.6782110506006565 0.6578669827807427 1.3735636746541118 0.6152110286320555 0.24223460809703987 0.31369345884265837 1.7355604254382873 0.11414569821395788 0.2794120919165177 1.8101241073163613e-07 6.742291647630883 0.715696691873369 YDCK(ub)GGELFANQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YDCKGGELFANQR 13 1 C9J2P9;Q75N03;C9K074;Q75N03-2 C9J2P9 CBLL1 E3 ubiquitin-protein ligase Hakai 1 9681050.0 5161600.0 3846600.0 672850.0 True False 7069983.006995171 3676644.4929948314 513936.6877807322 1.0 0.5200358316783918 0.07269277553739999 22.75327531678413 -7.909572471503154 0.47745468279708425 1.030464336219405 2.1808822200314965e-21 0.9952945843534488 0.025973863829334976 0.10559971841956271 0.1071278384884844 0.03845924838116469 0.07850591669027614 1.231480469223329e-08 7.909572471503154 -1.030464336219405 down YDDFLK(ub)STQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YDDFLKSTQK 10 1 Q07960;H0YE29 Q07960 ARHGAP1 Rho GTPase-activating protein 1 1 10519700.0 0.0 3627600.0 6892100.0 True False 0.0 2980226.4374318323 5529873.4140852615 0.0 YDDMAAAMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YDDMAAAMK 9 0 P61981;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;P31946-2 P61981;P31946;P31946-2 YWHAG;YWHAB 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 0 18617000.0 299600.0 11189000.0 7128400.0 False True 392778.50133052707 9519644.814380405 6390821.548441153 1.0 24.236674823425552 16.270802823454975 18.583356440564348 -9.112485128627789 10.447084972445625 1.0000000000106029 20.2537388239453 0.8862261815133898 3.252053626060701 0.0 0.0 3.1487873836681763 1.0495957945560586 7.71817944185627e-10 9.112485128627789 19.2537388239347 YDDMAAAMK ddPTM_RPMI8226_Bortezomib_2h_R1 2 YDDMAAAMK 9 0 P61981;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;P31946-2 P61981;P31946;P31946-2 YWHAG;YWHAB 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 0 21962830.0 5902900.0 2045630.0 14014300.0 False True 5715515.670584104 2862460.7268195204 10343534.410011886 1.0 0.500822828909677 1.8097289914270878 22.446452237813357 -6.8033573164128756 1.442279373955373 0.7257447574388234 1.8293081691462327 0.8417687528201874 0.2145437407785179 0.2159998059565885 0.8866949270474379 0.11700800432769279 0.27156640771104634 1.5726884003729865e-07 6.8033573164128756 1.1035634117074093 YDDMAAAMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YDDMAAAMK 9 0 P61981;P31946;Q4VY19;A0A0J9YWE8;Q4VY20;P31946-2 P61981;P31946;P31946-2 YWHAG;YWHAB 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed;14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 0 14661400.0 299600.0 7584700.0 6777100.0 False True 410370.21638556937 7249582.874751185 5176488.558755744 1.0 17.66595767744444 12.614191654425765 18.64656650208724 -9.726569472852207 8.997697845267377 0.9999999989074064 15.140074665935103 0.9126342744338372 2.062374842720803 0.0 5.452332721110506e-17 1.9968858548737023 0.6656286182912341 1.8768541593417937e-10 9.726569472852207 14.140074667027697 YDDMAAAMK(ub)NVTELNEPLSNEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 YDDMAAAMKNVTELNEPLSNEER 23 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 9544000.0 3549200.0 2940300.0 3054500.0 True False 3436532.5887338608 4114377.1234619343 2254434.8169641965 1.0 1.1972466482495414 0.6560202060515915 21.712522209869878 -6.808059156222231 1.4224563117155775 1.1077454468646353 0.6469454369315234 0.8547721812030027 0.08522841301673853 0.20944626262333646 0.8355762518294575 0.047115537298604314 0.10909797557547232 1.5557537044819457e-07 6.808059156222231 -0.4608000099331119 YDDMAACMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YDDMAACMK 9 0 P63104;E7EX29;E7ESK7;E9PD24;E7EVZ2;E5RIR4;E5RGE1 P63104 YWHAZ 14-3-3 protein zeta/delta 0 6842250.0 2916200.0 778250.0 3147800.0 False True 2823626.8272471786 1089009.2835201346 2323296.7480241917 1.0 0.3856774815324431 0.8228058770390807 21.42911800281488 -10.304979505811351 5.904450620325414 1.0000311683884113 0.6042416792858231 0.5221943040303599 0.17845692017880016 7.322594915148965e-05 8.619475656933815e-06 0.1728037468959318 0.05759672332232935 4.954735714593492e-11 10.304979505811351 -0.39578948910258827 YDDMATCMK(ub)AVTEQGAELSNEER ddPTM_RPMI8226_Bortezomib_1h_R1 2 YDDMATCMKAVTEQGAELSNEER 23 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 32264300.0 10569500.0 13291600.0 8403200.0 True False 13856716.855183596 11308545.090251002 7533717.473186219 1.0 0.8161056625776864 0.5436870473663439 23.72408213685031 -6.965463949019812 0.3499991739857789 1.0263262291767365 0.3242741255920525 0.9999223904936237 0.001651388248420918 0.07780387964020435 0.014306845901347587 0.0037393752126564754 0.023415139523038385 1.0827695925875243e-07 6.965463949019812 -0.7020521035846841 YDDMATCMK(ub)AVTEQGAELSNEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 YDDMATCMKAVTEQGAELSNEER 23 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 38154400.0 17825000.0 11292000.0 9037400.0 True False 17259155.131911717 15800954.487002073 6670233.8238114985 1.0 0.9155114700711235 0.38647510685377723 24.040858507822605 -6.9349383955365695 0.7050783573359326 1.006763336622459 0.26281507246834895 0.9974229138707668 0.013782909891520435 0.09015346822875334 0.06570450159634468 0.012948741418752444 0.04663755711966197 1.1616133764532139e-07 6.9349383955365695 -0.7439482641541102 down YDDMATCMK(ub)AVTEQGAELSNEER ddPTM_RPMI8226_Bortezomib_8h_R1 2 YDDMATCMKAVTEQGAELSNEER 23 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 163383500.0 55980000.0 67436000.0 39967500.0 True False 84925752.68619348 55401518.92012714 32067906.106622446 1.0 0.6523524039267521 0.37759931578252326 26.33969876379616 -7.620989580094722 0.20564996336643093 1.2015408735553843 6.6400170767374866e-15 0.9999193517533649 0.002287078662540823 0.13236276858032062 0.02327697572678446 0.04063656337444246 0.07600822578469665 2.3933731792456253e-08 7.620989580094722 -1.2015408735553776 down YDDMATCMK(ub)AVTEQGAELSNEER ddPTM_RPMI8226_Carfilzomib_1h_R1 2 YDDMATCMKAVTEQGAELSNEER 23 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 41821000.0 10569500.0 13958500.0 17293000.0 True False 14477329.77999758 13341767.31541319 13208749.56051453 1.0 0.9215627134395097 0.9123747100631936 23.7872921983732 -13.999999999999998 0.3025948876381142 1.726256994838088 0.9101741953972732 0.9996555913051303 0.0007296995999454898 16.759647496109135 0.17477900969097468 7.632004774225649 0.0032839049577733535 1.0000000000000041e-14 13.999999999999998 -0.8160827994408147 YDDMATCMK(ub)AVTEQGAELSNEER ddPTM_RPMI8226_Carfilzomib_2h_R1 2 YDDMATCMKAVTEQGAELSNEER 23 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 52789900.0 21029900.0 14308200.0 17451800.0 True False 17487293.63253415 14231118.886644678 21100890.691993803 1.0 0.8137976742249277 1.206641298270234 24.059803696464964 -6.777830289321919 1.5444798540443816 0.894269689335194 1.209535494872882 0.7595811305456387 0.07867272706924255 0.25396253755793546 1.1964549604457972 0.040127399822004535 0.09485086356691982 1.6678988555227033e-07 6.777830289321919 0.315265805537688 YDDMATCMK(ub)AVTEQGAELSNEER ddPTM_RPMI8226_Carfilzomib_8h_R1 2 YDDMATCMKAVTEQGAELSNEER 23 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 140518900.0 55980000.0 51642700.0 32896200.0 True False 72467213.53077097 48768738.34741828 26909429.14351591 1.0 0.672976591361694 0.3713324665379834 26.11082508588861 -7.291728597079784 0.23721080696834593 1.1316795327907638 9.210846691817362e-16 0.999955806829688 0.0017066262967898004 0.10480949288336283 0.014897373726769664 0.016113891041854587 0.046603568727100815 5.1082412871242346e-08 7.291728597079784 -1.131679532790763 down YDDYSSSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YDDYSSSR 8 0 P38159;P38159-2;Q96E39;H3BUY5 P38159 RBMX;RBMXL1 RNA-binding motif protein, X chromosome;RNA-binding motif protein, X chromosome, N-terminally processed;RNA binding motif protein, X-linked-like-1 0 3684180.0 1296200.0 453680.0 1934300.0 False True 1255052.8405040074 634836.7899099455 1427648.8022438507 1.0 0.5058247504981591 1.137520872563845 20.25931667543511 -6.697988077050411 1.8378241121052892 0.6925394039240887 1.1355864996693443 0.40814131940092135 0.20867460829926457 0.39971907004306906 2.623290231462499 0.09062769842019079 0.23367020401528266 2.0045270581058074e-07 6.697988077050411 0.4430470957452556 YDEMVESMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YDEMVESMK 9 0 P62258;B4DJF2;I3L3T1 P62258 YWHAE 14-3-3 protein epsilon 0 13737420.0 3816600.0 829020.0 9091800.0 False True 3695444.1221012156 1160052.0092821887 6710384.831846489 1.0 0.31391409826610706 1.8158534157542583 21.817316328621036 -6.782476168390911 1.5259702354084401 0.6127775023612027 1.8287468170918386 0.776154403067759 0.2904629203346856 0.24673468259062914 1.1349284595541778 0.14989000566494456 0.3529901249466198 1.650151549759922e-07 6.782476168390911 1.215969314730636 YDEMVESMK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 YDEMVESMKK 10 1 P62258;B4DJF2;I3L3T1 P62258 YWHAE 14-3-3 protein epsilon 1 6069500.0 0.0 3498000.0 2571500.0 True False 0.0 2873754.5700012567 2063241.8978715092 0.0 YDEMVESMK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YDEMVESMKK 10 1 P62258;B4DJF2;I3L3T1 P62258 YWHAE 14-3-3 protein epsilon 1 6133400.0 0.0 2949900.0 3183500.0 True False 0.0 2785735.4718294945 2604135.6654684404 0.0 YDGIILPGK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 YDGIILPGK 9 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 90666300.0 36361000.0 49602000.0 4703300.0 True False 47669623.12042491 42201574.94708168 4216647.633239336 1.0 0.8852928171987089 0.08845565282920471 25.506566883610244 -7.0403780644198815 0.812872210577734 1.0038327916627259 2.5827043027127896e-26 0.9960206053063787 0.025572566115122344 0.07836352683622787 0.08741283339723824 0.023198761171209715 0.05842981416728168 9.112172561336661e-08 7.0403780644198815 -1.0038327916627259 down YDGIILPGK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 YDGIILPGK 9 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 216799000.0 110450000.0 89646000.0 16703000.0 True False 106943825.20727341 125442115.29771411 12327983.220740858 1.0 1.172972025776974 0.11527531577299906 26.67227794473399 -6.864938038156638 1.1604648969297784 1.095398994086023 0.05899157539876804 0.959368789651723 0.09337753902261395 0.14180483739186553 0.3600999888526246 0.06261861462045676 0.1470897142288195 1.3647778388520178e-07 6.864938038156638 -1.036407418687255 down YDGIILPGK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YDGIILPGK 9 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 230712400.0 110450000.0 115180000.0 5082400.0 True False 91844068.76463507 114559502.47855999 6145106.341637488 1.0 1.2473260823422012 0.06690803689659366 26.452683220168268 -6.852000626797553 1.2253705598855886 1.1322442446720997 0.01785928636765695 0.9431704307238112 0.12117073005030604 0.15526930036508838 0.44763405794959993 0.07733510442059975 0.17920489052794317 1.4060454948466784e-07 6.852000626797553 -1.1143849583044427 down YDGIILPGK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YDGIILPGK 9 0 P62913;Q5VVC8;P62913-2 P62913;P62913-2 RPL11 60S ribosomal protein L11 1 73134000.0 24062000.0 17790000.0 31282000.0 True False 31148733.332929794 16799970.861333165 25588996.980425283 1.0 0.5393468389795673 0.8215100340331697 24.892670161282446 -10.340706990137315 6.052582612982101 1.0000326695174027 0.6804284365063688 0.6310382084939691 0.11519264201245562 5.078720681391647e-05 5.53226042670918e-06 0.11154617479604068 0.03717826534332265 4.563446988182893e-11 10.340706990137315 -0.3196042330110339 YDGIYK(ub)VVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YDGIYKVVK 9 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2;A0A087WWG9;Q96PU4 A0A087WVR3;Q96PU4 UHRF1;UHRF2 E3 ubiquitin-protein ligase UHRF1;E3 ubiquitin-protein ligase UHRF2 1 6193800.0 1750200.0 1565200.0 2878400.0 True False 1694640.859011046 2190192.522410172 2124460.689850956 1.0 1.292422822667169 1.2536347619345987 20.692548128335964 -10.106621383720325 4.671504369435922 0.9999816858681279 1.273028792305577 0.9850886868360368 0.015835159500552375 3.0206239434162443e-06 5.776696943542159e-07 0.015333355276344784 0.005110775750241667 7.823095218554756e-11 10.106621383720325 0.2730471064374491 YDGIYK(ub)VVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YDGIYKVVK 9 1 A0A087WVR3;A0A087WTW0;Q96T88;Q96T88-2;A0A087WWG9;Q96PU4 A0A087WVR3;Q96PU4 UHRF1;UHRF2 E3 ubiquitin-protein ligase UHRF1;E3 ubiquitin-protein ligase UHRF2 1 10101400.0 2110900.0 2083000.0 5907500.0 True False 2732601.662059741 1967079.2188958398 4832395.616068732 1.0 0.7198558231912672 1.7684229952587522 21.381843739373647 -6.835618250050117 1.302595071254673 0.8507868762841645 1.8000236830786938 0.9166531546773379 0.12797332308269116 0.17397979279470074 0.5753132448935572 0.07708812433409071 0.17744102072173157 1.4600971388923122e-07 6.835618250050117 0.9492368067945293 YDGQVAVFGSDLQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YDGQVAVFGSDLQEK 15 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 62106000.0 11630000.0 26046000.0 24430000.0 False True 15247042.625080198 22160038.326512814 21902217.949107423 1.0 1.4533991195158906 1.4364895860578222 23.86202610335354 -10.089387236628417 4.970375955661648 0.9999867500010666 1.4449443527890171 0.9989179601828725 0.006903288134283125 1.0136290882697114e-06 1.8571095568601054e-07 0.006684278840617189 0.0022280266637758556 8.139781805463124e-11 10.089387236628417 0.4449576027879505 YDGQVAVFGSDLQEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YDGQVAVFGSDLQEK 15 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 46662800.0 12976000.0 4989800.0 28697000.0 False True 12564083.98270328 6982253.161463252 21180394.808453627 1.0 0.5557311755537115 1.685789018730872 23.582802155821263 -6.800055604197989 1.4556380069377421 0.7548938784476317 1.7014189711620509 0.8323402821486645 0.19033592554746154 0.2206769816140901 0.9231222494198522 0.10286529496224728 0.2392237287634131 1.5846902861908377e-07 6.800055604197989 0.9465250927144192 YDGQVAVFGSDLQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YDGQVAVFGSDLQEK 15 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 53772000.0 11630000.0 21898000.0 20244000.0 False True 15929925.288932474 20930473.952997636 15462784.138267273 1.0 1.3139091096390363 0.9706752453516054 23.92523616487643 -6.666104791785859 1.9510690052495765 1.201032411250624 0.9720802781315747 0.26195420008855186 0.13346231874827502 0.47012528457556335 3.4463071756450834 0.055142342234488724 0.14808496181524206 2.157223825488954e-07 6.666104791785859 -0.22895213311904938 YDGQVAVFGSDLQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YDGQVAVFGSDLQEK 15 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 26960900.0 12976000.0 8104900.0 5880000.0 False True 10790118.934268018 8061237.295003301 7109480.813951757 1.0 0.747094387384541 0.6588880861519485 23.36320743125554 -13.999999999999998 0.14687360029676472 2.217401340341688 0.5582667140453283 0.9995770068253108 0.0029732934819473975 11.947344240289757 0.12052728848759128 4.155240859796741 0.09043371201166987 1.0000000000000041e-14 13.999999999999998 -1.6591346262963595 YDGQVAVFGSDLQEK(ub)LGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YDGQVAVFGSDLQEKLGK 18 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 21401800.0 4827800.0 8630000.0 7944000.0 True False 6329292.5524817 7342437.639476524 7122031.084228791 1.0 1.16007240597491 1.125249153072607 22.59361282283814 -10.101242387651112 4.497584362171513 0.999987138602268 1.142660779528729 0.9572236009519114 0.014216533486477813 1.8453595076945248e-06 3.6878986412983045e-07 0.013766348163236061 0.004588366449916843 7.920591444781108e-11 10.101242387651112 0.14267364092646095 YDGQVAVFGSDLQEK(ub)LGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YDGQVAVFGSDLQEKLGK 18 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 38837000.0 13225000.0 12686000.0 12926000.0 True False 12805179.613998996 17751585.95661606 9540292.82831206 1.0 1.3862816837968839 0.7450338937754792 23.61022415349274 -6.7435716353924455 1.6734156100304687 1.2288749962736065 0.7443408733294573 0.6209746130940828 0.16229262006938908 0.31138109326868296 1.7133766657889624 0.07667878322542122 0.1874450879133402 1.8047970174704678e-07 6.7435716353924455 -0.4845341229441492 YDGQVAVFGSDLQEK(ub)LGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YDGQVAVFGSDLQEKLGK 18 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 94344000.0 28632000.0 19512000.0 46200000.0 True False 43436837.27958367 16029931.152048161 37068549.749820635 1.0 0.3690400166308288 0.8533897049462144 25.37241572575227 -9.959777923619123 6.749349341773915 1.0000000370584705 0.611214860788584 0.4621031909630099 0.19773493224147046 1.1028089991426836e-07 1.6907808152753657e-08 0.19145604200110133 0.06381867496122086 1.0970390233873568e-10 9.959777923619123 -0.3887851762698865 YDGQVAVFGSDLQEK(ub)LGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YDGQVAVFGSDLQEKLGK 18 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 24064900.0 4827800.0 8290100.0 10947000.0 True False 6612768.1263893545 7923815.970305316 8361544.06054199 1.0 1.1982600658087506 1.2644544464176588 22.65682288436103 -13.999999999999785 0.15325761573802807 0.036201190113922664 1.334622696776646 0.9995557305566225 0.002368303963327671 11.97167758978509 0.12345309161802584 3.4332151371399546 0.06345589512069169 1.000000000000495e-14 13.999999999999785 1.2984215066627232 YDGQVAVFGSDLQEK(ub)LGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YDGQVAVFGSDLQEKLGK 18 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 38860000.0 13225000.0 14425000.0 11210000.0 True False 10997173.466838364 14347289.661861664 13553959.17081619 1.0 1.3046342958147812 1.2324948052959004 23.390629428927017 -10.057023945320195 4.3295200848747255 0.9999785181073922 1.2685645505478076 0.9486639499842365 0.029450823818380732 27217451.326350212 18789056.08048354 6879.2382233262915 0.010777898046274124 8.769524680389381e-11 10.057023945320195 0.26858603244041535 YDGQVAVFGSDLQEK(ub)LGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YDGQVAVFGSDLQEKLGK 18 1 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 1 110493000.0 28632000.0 27668000.0 54193000.0 True False 37064688.42109747 26128251.47787334 44330430.06713724 1.0 0.7049364932203493 1.1960286719125381 25.14354204784472 -6.743981828875264 1.6720362042491403 0.8252592684331067 1.1965809514095298 0.6227808371136265 0.12396757922408787 0.31062616815806643 1.7065737033455415 0.058617896786633594 0.14322373807856206 1.8030931817114633e-07 6.743981828875264 0.3713216829764231 YDGSQQALDLK(ub)GLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YDGSQQALDLKGLR 14 1 E9PIN3;Q9UBU9;Q9UBU9-2;B4E227 E9PIN3 NXF1 Nuclear RNA export factor 1 1 9063900.0 2479900.0 2418000.0 4166000.0 True False 2401176.931928629 3383520.0097034206 3074799.622678945 1.0 1.409108993474201 1.2805385483231595 21.195310282518218 -10.123809606147224 4.887200168872451 0.9999819915494169 1.3448237709003812 0.905577638078221 0.052488664442966244 1.0299775028833367e-05 1.8466601951860037e-06 0.05082458315928652 0.016940643603518896 7.519524762660012e-11 10.123809606147224 0.3448417793509643 YDGSQQALDLK(ub)GLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YDGSQQALDLKGLR 14 1 E9PIN3;Q9UBU9;Q9UBU9-2;B4E227 E9PIN3 NXF1 Nuclear RNA export factor 1 1 9315100.0 2298200.0 3420700.0 3596200.0 True False 3147906.646519747 3269562.163257793 2746851.62606386 1.0 1.0386464817413013 0.8725962788956005 21.58596132662446 -6.845405327390405 1.2569677327808313 1.0205694639179281 0.8665208132291573 0.9333576449402896 0.018314415570030225 0.16258809748209904 0.4966353109463327 0.01141312251889883 0.026345943203370577 1.4275609927523748e-07 6.845405327390405 -0.15404865068877083 YDGSQQALDLK(ub)GLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YDGSQQALDLKGLR 14 1 E9PIN3;Q9UBU9;Q9UBU9-2;B4E227 E9PIN3 NXF1 Nuclear RNA export factor 1 1 8498600.0 2479900.0 3079300.0 2939400.0 True False 2062146.7281975402 3062711.199706807 3554014.949749971 1.0 1.4852052755643774 1.7234539623940472 20.975715557952494 -10.726103434470058 0.13967073914376893 4.459331772784451e-12 2.0938090695722282 0.9997253212444951 0.004989099960795163 2.7359002977021882 0.07790846261384922 1.1517716946642398 0.24433537668108274 1.8788692794736345e-11 10.726103434470058 2.0938090695677687 YDLDFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YDLDFK 6 0 P06733;A0A2R8Y6G6;U3KQP4;P06733-2;P13929;P13929-3;P13929-2;E5RGZ4;P09104;P09104-2;F5H0C8 P06733;P06733-2;P13929;P09104 ENO1;ENO2;ENO3 Alpha-enolase;Beta-enolase;Enolase;Gamma-enolase 0 58046700.0 1934700.0 34866000.0 21246000.0 False True 2536410.435661452 29664128.706603553 19047667.7260228 1.0 11.695318821248922 7.509694589730505 21.274356787034147 -9.276516016640732 10.33048553115662 1.0000474621853286 9.602506705489775 0.8492175906780537 1.7087739372614574 0.0 0.0 1.6545132749153435 0.5515044167541148 5.290344862282012e-10 9.276516016640732 8.602459243304446 YDLDFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YDLDFK 6 0 P06733;A0A2R8Y6G6;U3KQP4;P06733-2;P13929;P13929-3;P13929-2;E5RGZ4;P09104;P09104-2;F5H0C8 P06733;P06733-2;P13929;P09104 ENO1;ENO2;ENO3 Alpha-enolase;Beta-enolase;Enolase;Gamma-enolase 0 57714800.0 19959000.0 7279800.0 30476000.0 False True 19325412.470004257 10186662.10365548 22493421.33959757 1.0 0.527112273513779 1.1639296897031568 24.203995870707285 -6.707880642610586 1.8031633073475837 0.7086451084233608 1.1623161769601613 0.4548622732348765 0.19933998981165382 0.3793431071379481 2.4030427910928966 0.0880271202626983 0.22417306156841466 1.9593830978406979e-07 6.707880642610586 0.4536710685368005 YDLDFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YDLDFK 6 0 P06733;A0A2R8Y6G6;U3KQP4;P06733-2;P13929;P13929-3;P13929-2;E5RGZ4;P09104;P09104-2;F5H0C8 P06733;P06733-2;P13929;P09104 ENO1;ENO2;ENO3 Alpha-enolase;Beta-enolase;Enolase;Gamma-enolase 0 50306700.0 1934700.0 23399000.0 24973000.0 False True 2650010.8733016066 22365154.809854437 19074891.73507948 1.0 8.439646431333335 7.198042818335448 21.33756684855704 -9.75768920192499 7.388781330268068 0.9999999954861408 7.818844624834471 0.9757373333360355 0.5068825524404298 3.597554274764449e-08 7.918269455103563e-09 0.4907869246777401 0.16359564034036497 1.747071978524066e-10 9.75768920192499 6.81884462934833 YDLGGLVMVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YDLGGLVMVK 10 0 Q15274 Q15274 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] 0 5586400.0 1240100.0 2110400.0 2235900.0 False True 1625783.1091454823 1795536.5462747712 2004550.5162672633 1.0 1.1044133354408583 1.2329753612219914 20.632703373950328 -6.968330040324819 0.29536530931331645 0.9764385952298261 1.3649521242201608 0.9999662640432966 0.000553392845279855 0.07684840838835119 0.010959571463727565 0.0021834770425821427 0.011588092430882397 1.0756474690299774e-07 6.968330040324819 0.38851352899033464 YDLHQVK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 YDLHQVKK 8 1 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 1 6346340.0 1253900.0 3130300.0 1962140.0 True False 1643875.042784871 2663271.4418138335 1759116.5749759176 1.0 1.6201179362769653 1.0701035840265676 20.648669207756107 -10.230041274739047 4.384070346463213 0.9998546532937485 1.3451107601587413 0.3442354680981683 0.22454241906038647 158313361.09090918 59.8048087554677 232282.2951334651 0.07686684251908314 5.88787695138876e-11 10.230041274739047 0.34525610686499286 YDLHQVK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YDLHQVKK 8 1 I3L1L3;Q9BQG0;Q9BQG0-2 I3L1L3 MYBBP1A Myb-binding protein 1A 1 4362560.0 1253900.0 2062160.0 1046500.0 True False 1717500.715373381 1971046.9525488024 799338.253344039 1.0 1.1476251129946697 0.4654078139177162 20.711879269279 -6.8500592290016185 1.2348334905457257 1.0787808152412255 0.43810849906454924 0.9403878880507822 0.07155441338120161 0.15739194989410796 0.4618029277876509 0.0453429818531411 0.10492852158514089 1.4123449161476602e-07 6.8500592290016185 -0.6406723161766763 down YDLPASYK(ub)FHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YDLPASYKFHK 11 1 B8ZZE3;B8ZZC8;Q9NRN9;H7C0M7;B8ZZY8;E7EMN2 B8ZZE3 METTL5 Methyltransferase-like protein 5 1 5192780.0 636930.0 594050.0 3961800.0 True False 616711.0057878555 831257.262929825 2924085.7285476336 1.0 1.3478878358395505 4.741419726752047 19.2342350672322 -6.92660450631351 0.7741561097447802 0.9413810638899041 5.381450401928902 0.9958277553179469 0.10901415286301702 0.09443975756017564 0.0866015236968603 0.09737971833609704 0.3129848335462517 1.1841193925205279e-07 6.92660450631351 4.440069338038998 up YDNLEMEYLQK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 YDNLEMEYLQKR 12 1 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 11066500.0 2845000.0 3400300.0 4821200.0 True False 3729822.551019193 2892988.49426559 4322348.47221599 1.0 0.7756370322430127 1.1588616919683983 21.830675564186905 -6.747989238081268 1.6570137733923835 0.8677587403428759 1.1595215398147083 0.6404219464699336 0.09427114199801377 0.30354714330977434 1.6391262253916195 0.044952182653234384 0.10937481074608175 1.7865318449800679e-07 6.747989238081268 0.29176279947183237 YDNLEMEYLQK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 YDNLEMEYLQKR 12 1 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 15853800.0 3383900.0 3493900.0 8976000.0 True False 3276479.946753211 4889032.490447802 6624916.32577201 1.0 1.4921600528312498 2.021961505467748 21.643715271261833 -6.970185702821589 0.25371136959300455 0.8393590291446738 2.690353484946126 0.9999837950242204 0.001679881760275395 0.07624249603849734 0.008814279976859936 0.0115255400936831 0.05047427833220367 1.0710612252244978e-07 6.970185702821589 1.8509944558014522 YDNLEMEYLQK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 YDNLEMEYLQKR 12 1 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 37112800.0 6443800.0 12168000.0 18501000.0 True False 9775715.704881983 9996525.330982063 14844269.24072362 1.0 1.0225875662474317 1.5184841385383585 23.220770898965185 -6.916423419862869 0.8508248985478197 0.9875851806608691 1.5922255757917065 0.9931283769560378 0.019834312089204272 0.10032266791026584 0.11685517965874924 0.016773111962228686 0.048647359076477145 1.2122064210551134e-07 6.916423419862869 0.6046403951308374 YDNLEMEYLQK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YDNLEMEYLQKR 12 1 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 12207800.0 2845000.0 3028400.0 6334400.0 True False 3896873.383234131 2894595.2744204095 4838345.1810630495 1.0 0.742799416289502 1.2415967123488019 21.893885625709796 -6.766609296803792 1.5879804752729978 0.8518338894426529 1.2440134726464032 0.7172097716510495 0.1083057434668193 0.2719546106995195 1.3529644297336887 0.05378270194359046 0.12839908113268952 1.711554383836222e-07 6.766609296803792 0.39217958320375024 YDNLEMEYLQK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YDNLEMEYLQKR 12 1 Q8WUM0 Q8WUM0 NUP133 Nuclear pore complex protein Nup133 1 15078900.0 3383900.0 4863800.0 6831200.0 True False 2813862.7821878525 4837597.744011295 8259572.336099881 1.0 1.7192017232090953 2.9353145392817788 21.42412054669611 -6.963190382706899 0.3878644753830674 0.9235105067635756 3.7745523569034143 0.9998708356707773 0.009077522271737817 0.07858059989609112 0.01705982902796515 0.015721894335045023 0.10239121183888499 1.0884528410683896e-07 6.963190382706899 2.851041850139839 YDNSLK(ub)IISNASCTTNCLAPLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YDNSLKIISNASCTTNCLAPLAK 23 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 19956300.0 4459300.0 10195000.0 5302000.0 True False 5846185.483922626 8673945.73979874 4753399.900375254 1.0 1.4836932156279732 0.8130771617574228 22.479064172072352 -6.7131887555069865 1.7839553451803272 1.2963905888012417 0.8145073679266103 0.48019934804351094 0.20372689498452728 0.3686920326194253 2.289202163765764 0.09081517773574571 0.2298154282613037 1.9355805282245197e-07 6.7131887555069865 -0.4818832208746314 YDNSLK(ub)IISNASCTTNCLAPLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YDNSLKIISNASCTTNCLAPLAK 23 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 391741000.0 39246000.0 46945000.0 305550000.0 True False 59539051.26692308 38567297.9670409 245157908.57267767 1.0 0.6477647383754495 4.117598506459157 25.827332897151102 -6.8818857614585305 1.069187945605742 0.7757130022273626 4.372610449530784 0.9751765665128592 0.24567753607257264 0.1259744932845678 0.2622827847520081 0.17668855248606619 0.42941468172936825 1.3125451106813392e-07 6.8818857614585305 3.596897447303421 up YDNSLK(ub)IISNASCTTNCLAPLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YDNSLKIISNASCTTNCLAPLAK 23 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 28270000.0 4459300.0 15294000.0 8516700.0 True False 6108023.718051298 14618260.50950527 6505230.866942356 1.0 2.3932881050057673 1.0650303874422058 22.542274233595244 -6.634950878585358 2.062378699952685 1.9145813872998332 1.0704554614199653 0.13562624357456476 0.5969003176086247 0.5462376817579884 4.433861837509456 0.23618726604689153 0.6611415550164838 2.3176567765810127e-07 6.634950878585358 -0.8441259258798679 YDNSLK(ub)IISNASCTTNCLAPLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YDNSLKIISNASCTTNCLAPLAK 23 1 P04406;E7EUT5;P04406-2 P04406;P04406-2 GAPDH Glyceraldehyde-3-phosphate dehydrogenase 1 283772000.0 39246000.0 40596000.0 203930000.0 True False 50804720.654316574 38336796.91324799 166816832.4985016 1.0 0.7545912352140989 3.2834907927857717 25.59845921924355 -6.883071963969906 1.0624832072721688 0.8407082985100672 3.4736401696793613 0.9760814842966846 0.17610805214600872 0.12494526270028111 0.25611913432825045 0.12730515985594082 0.3104151206461164 1.308965005384536e-07 6.883071963969906 2.632931871169294 up YDPHTGHWTNVTPMATK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 YDPHTGHWTNVTPMATKR 18 1 Q53G59;Q53G59-2;Q9H7R2 Q53G59 KLHL12 Kelch-like protein 12 1 45350900.0 7978900.0 19262000.0 18110000.0 True False 12104574.635724725 15824545.605307102 14530550.562105017 1.0 1.3073194293505759 1.2004181063265462 23.529049047000445 -10.120472139700864 4.45057050167523 0.999971507573753 1.2538687677881 0.8826227334560798 0.0436422824332123 30440376.374538876 0.5904469137805265 9644.634974698925 0.014939914084335277 7.577533417211797e-11 10.120472139700864 0.253897260214347 YDPHTGHWTNVTPMATK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YDPHTGHWTNVTPMATKR 18 1 Q53G59;Q53G59-2;Q9H7R2 Q53G59 KLHL12 Kelch-like protein 12 1 12604200.0 3253700.0 3879600.0 5470900.0 True False 2705595.7133498653 3858699.8247596947 6614839.895416451 1.0 1.4261923190224686 2.4448737343786124 21.367514848431533 -6.956417206160837 0.4832926499449544 0.9762905670776177 2.9374838593438946 0.9996133615281197 0.011919254727956045 0.08100674724557443 0.026056076631839252 0.014460418225971475 0.08402441057061565 1.10556121332887e-07 6.956417206160837 1.9611932922662767 up YDPHTGHWTNVTPMATK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YDPHTGHWTNVTPMATKR 18 1 Q53G59;Q53G59-2;Q9H7R2 Q53G59 KLHL12 Kelch-like protein 12 1 35648900.0 7978900.0 12054000.0 15616000.0 True False 10328843.337632535 11383184.303682417 12774048.233690973 1.0 1.102077350927422 1.2367355972134342 23.300175369092894 -6.967304503809835 0.31602307054365125 0.9806764305836642 1.362454502063883 0.999953060869452 0.0006642104884235143 0.0771875303766978 0.012147220118019839 0.0020750895400199957 0.011887354647587167 1.0781904882694685e-07 6.967304503809835 0.3817780714802188 YDPK(ub)TQEWSFLPSITR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YDPKTQEWSFLPSITR 16 1 Q53G59;Q53G59-2;Q9H7R2 Q53G59 KLHL12 Kelch-like protein 12 1 21793400.0 6921100.0 8686900.0 6185400.0 True False 8959500.385277217 8203466.378601184 5059720.6675635325 1.0 0.9156164993398077 0.5647324571666926 23.0949868538638 -6.9439841548394226 0.6213924143580009 1.003836881485441 0.4578783742442678 0.9986405675878237 0.006949081082436988 0.08599510279809738 0.04667909336525836 0.006989390109152995 0.029711100448116704 1.1376687927193552e-07 6.9439841548394226 -0.5459585072411732 YDPQK(ub)EAELR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YDPQKEAELR 10 1 B4DDF4;B4DUT8;Q99439;A0A087X271;H3BVI6;Q99439-2;K7ES69 B4DDF4 CNN2 Calponin;Calponin-2 1 12013800.0 2013400.0 1382000.0 8618400.0 True False 3054474.999256556 1135371.3023847146 6914969.462421087 1.0 0.37170751198194724 2.2638815063486053 21.54249300139524 -6.817198876501147 1.3838781708974326 0.6603554248053031 2.3027804617843066 0.8778228448846711 0.27504112269152936 0.19715557492602045 0.7426495599794991 0.15620604781308398 0.3603389106624508 1.5233550039903064e-07 6.817198876501147 1.6424250369790037 up YDPQK(ub)EAELR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YDPQKEAELR 10 1 B4DDF4;B4DUT8;Q99439;A0A087X271;H3BVI6;Q99439-2;K7ES69 B4DDF4 CNN2 Calponin;Calponin-2 1 17829700.0 2013400.0 4613900.0 11202400.0 True False 2606385.9900474157 4357132.409055939 9163678.146330662 1.0 1.671714176524051 3.515856124657866 21.31361932348769 -6.953425330760992 0.5198804437499938 0.9686342409156828 4.30121710674785 0.9994434032126667 0.025093250130240156 0.08213875497182893 0.030490361620573357 0.028432854804882574 0.15232534015853652 1.1132037720080795e-07 6.953425330760992 3.3325828658321672 YDQYK(ub)TPMENIGLQDSLLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YDQYKTPMENIGLQDSLLSR 20 1 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 1 7934900.0 1988500.0 2067900.0 3878500.0 True False 1925376.155949868 2893623.253956038 2862604.4974940713 1.0 1.5028872384308163 1.4867767467920208 20.876708898409202 -10.05980258032228 4.763700743325755 0.9999836470569683 1.4948319925912554 0.9992056378827797 0.006577080701346507 1.1477128371617125e-06 2.265081008982643e-07 0.006368442208850759 0.002122743664141158 8.713595987597951e-11 10.05980258032228 0.49484834553428714 YDTGSDDWDTSEK(ub)CR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YDTGSDDWDTSEKCR 15 1 P32019-3;P32019-2;P32019;E7ESY0;P32019-4 P32019-3 INPP5B Type II inositol 1,4,5-trisphosphate 5-phosphatase 1 3106180.0 1679600.0 829060.0 597520.0 True False 2201971.865269538 705367.4796505694 535694.3622165642 1.0 0.32033446511099134 0.24327938547525046 21.070364604940615 -13.999999999999998 0.30731015249600513 7.46753525702779 0.2257183997935378 0.9996660683122152 0.006213413484823492 17.080493857574726 0.17628882520321193 70.53251660425087 0.027000213161919105 1.0000000000000041e-14 13.999999999999998 -7.2418168572342525 YDYVLTGYTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YDYVLTGYTR 10 0 O00764;F2Z2Y4;O00764-3 O00764;O00764-3 PDXK Pyridoxal kinase 0 56320000.0 12795000.0 16285000.0 27240000.0 False True 16774368.906956255 13855341.478432802 24421466.10453073 1.0 0.8259828763326562 1.455879874825172 23.999755153919768 -6.833030417267886 1.3143487414122261 0.9071954338134928 1.4738995878013894 0.9117961881923051 0.07888015983666172 0.17709991650874518 0.5972688891764651 0.04710610209946007 0.10840383734076227 1.4688234000773581e-07 6.833030417267886 0.5667041539878966 YDYVLTGYTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YDYVLTGYTR 10 0 O00764;F2Z2Y4;O00764-3 O00764;O00764-3 PDXK Pyridoxal kinase 0 39665500.0 9475200.0 3606300.0 26584000.0 False True 9174414.962462248 5046314.396606054 19620852.89709482 1.0 0.5500420917577195 2.1386489468129457 23.12918473189418 -6.831035046477282 1.3232399056037523 0.7597406738608495 2.182321132867904 0.9079404756237826 0.20284743359047014 0.17953363015207469 0.6144283460901518 0.12034816041373013 0.2769548842832275 1.475587452258438e-07 6.831035046477282 1.4225804590070545 up YDYVLTGYTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YDYVLTGYTR 10 0 O00764;F2Z2Y4;O00764-3 O00764;O00764-3 PDXK Pyridoxal kinase 0 36473000.0 12795000.0 11893000.0 11785000.0 False True 17525657.271873698 11367527.935108274 9001625.719693732 1.0 0.6486220607173241 0.5136255707875858 24.06296521544266 -13.999999999999998 0.13248769261679835 2.670785967168846 0.3304121013238094 0.999634502813 0.0039193143981090355 11.93370354884616 0.1134305901457684 5.181170316566521 0.16310347075624929 1.0000000000000041e-14 13.999999999999998 -2.3403738658450366 YDYVLTGYTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YDYVLTGYTR 10 0 O00764;F2Z2Y4;O00764-3 O00764;O00764-3 PDXK Pyridoxal kinase 0 21022900.0 9475200.0 7255000.0 4292700.0 False True 7879048.622532085 7215915.874995256 5190283.722797743 1.0 0.9158359366332076 0.6587449794325225 22.909590007328458 -6.951043994186221 0.5472604359208335 1.0036146029913693 0.5589451283346123 0.9992806959077393 0.003893077277812696 0.08306918179774812 0.03424797329568772 0.004240484937912904 0.021317087046637765 1.1193244897530113e-07 6.951043994186221 -0.444669474656757 YDYVLTGYTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YDYVLTGYTR 10 0 O00764;F2Z2Y4;O00764-3 O00764;O00764-3 PDXK Pyridoxal kinase 0 25816100.0 6549000.0 9159100.0 10108000.0 False True 8477809.600089664 8649388.033504035 8268447.716838386 1.0 1.020238533478336 0.9753047198359983 23.01526013514028 -6.784278150905193 1.519355921644058 1.01139603647747 0.974900861329233 0.7821788238070838 0.008575481840085579 0.24398813682075762 1.1127218952203897 0.004444437008256469 0.010449463037896898 1.6433188960106065e-07 6.784278150905193 -0.03649517514823686 YEAAGTLVTLSSAPTAIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEAAGTLVTLSSAPTAIK 18 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 14798400.0 2928500.0 5664200.0 6205700.0 False True 3839291.8596343426 4819123.438878667 5563593.693277772 1.0 1.2552115377176989 1.449119758717081 21.872408806102477 -6.974169616056336 0.12290209824727594 0.6661157545735509 2.0432081129785464 0.999999387108542 0.00014387101895136178 0.07497147310041577 0.0036682879829558735 0.013210174449743803 0.02750088970380499 1.0612809872242194e-07 6.974169616056336 1.3770923584049957 YEAAGTLVTLSSAPTAIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEAAGTLVTLSSAPTAIK 18 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 8874500.0 3132900.0 0.0 5741600.0 False True 3033447.8043627604 0.0 4237702.715692139 1.0 0.0 1.3969921320542906 21.532527056882625 -6.71455680682532 1.7789624157747246 0.3880984636296462 1.3941688821984974 0.4866854696767754 0.421108627618648 0.3660034918913239 2.2605840162416833 0.18818156107663433 0.4754464704454218 1.929492937088019e-07 6.71455680682532 1.0060704185688514 YEAAGTLVTLSSAPTAIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEAAGTLVTLSSAPTAIK 18 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 11085100.0 2928500.0 3035300.0 5121300.0 False True 4011245.589736784 2901190.409605159 3911754.4164843084 1.0 0.7232642192310976 0.9751969379518834 21.93561886762537 -10.375079636638432 7.7623465171039685 1.0000021255183518 0.8492305787551865 0.3231925068359969 0.10285110172967407 3.7833594030443615e-06 3.0454375129867144e-07 0.09958655470969265 0.0331950503448427 4.21619183972439e-11 10.375079636638432 -0.1507715467631653 YEAAGTLVTLSSAPTAIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEAAGTLVTLSSAPTAIK 18 0 P53618;E9PP73 P53618 COPB1 Coatomer subunit beta 0 5623600.0 3132900.0 0.0 2490700.0 False True 2605145.161002492 0.0 3011493.854304366 1.0 0.0 1.1559792902847323 21.3129323323169 -10.685099683697363 4.514860341687253 1.0159805627639835 0.577989645145653 0.15088656050478555 0.4719265690705064 0.07666655500528863 0.005347298243762329 0.46148060648664696 0.15231364522022064 2.064906143101652e-11 10.685099683697363 -0.43799091761833053 YEAANWK(ub)YK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEAANWKYK 9 1 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 1152036160.0 365797460.0 498520000.0 287718700.0 True False 479564012.4476414 424142759.21574056 257948328.91665414 1.0 0.8844340863922693 0.5378809131238071 28.8371481588616 -6.951460061224538 0.5425782300872634 1.005017411695001 0.40122289667346034 0.9993109352047018 0.005154406234759405 0.08290471126354107 0.033576628408203496 0.005649399846909232 0.02871158625014715 1.1182526570863766e-07 6.951460061224538 -0.6037945150215407 YEAANWK(ub)YK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEAANWKYK 9 1 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 1791087590.0 497712990.0 458489000.0 834885600.0 True False 481913363.56676674 641566048.6885488 616204015.3288732 1.0 1.331289184305143 1.2786613983231057 28.84419856699188 -10.052421020419109 4.445544873204107 0.9999816381225862 1.3049752913413881 0.9781541232664175 0.021485203752492205 3266719.3918656316 3693409.940184135 474.5309014113369 0.007354956699188556 8.862963883891074e-11 10.052421020419109 0.3049936532188019 YEAANWK(ub)YK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YEAANWKYK 9 1 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 2971442700.0 1357952700.0 727830000.0 885660000.0 True False 2060113525.5403483 597943049.938255 710608912.801432 1.0 0.29024762107778507 0.34493677362515546 30.940076695385653 -10.50318318233624 9.55049111455117 1.0000122800286841 0.3175921973514703 0.9952061025177101 0.02232675303438138 5.83795325779555e-06 3.036746005756515e-07 0.021618173224252864 0.0072059285564204135 3.139184328877744e-11 10.50318318233624 -0.6824200826772138 YEAANWK(ub)YK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEAANWKYK 9 1 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 1009317460.0 365797460.0 333270000.0 310250000.0 True False 501042666.26666087 318545029.4234877 236975339.79931983 1.0 0.6357642789126351 0.4729643915658048 28.90035822038449 -13.999999999892744 0.10893089569829609 2.7608705134462395 0.1696645147673068 0.9997484950623756 0.0034943090813526188 12.019038088970715 0.09997632929022689 4.664090755197299 0.2694700345401348 1.0000000002469671e-14 13.999999999892744 -2.591205998678933 YEAANWK(ub)YK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEAANWKYK 9 1 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 1723712990.0 497712990.0 842240000.0 383760000.0 True False 413870403.6089823 837702685.94845 464002441.69424015 1.0 2.024070043771231 1.1211297972701177 28.624603842426158 -6.615862598938089 2.1322762221312983 1.6814773719518916 1.1245155222090089 0.06893606146705966 0.44085564240141517 0.5966373351936352 5.148852546457354 0.17024240173962363 0.488967945045706 2.4217951273638915e-07 6.615862598938089 -0.5569618497428828 YEAANWK(ub)YK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YEAANWKYK 9 1 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 1 2770382700.0 1357952700.0 949030000.0 463400000.0 True False 1757896539.399553 896215646.2355833 379065954.8855278 1.0 0.5098227490348806 0.21563610052671578 30.711203017478102 -8.57123000919375 0.252694281783221 1.2425164048362785 6.948582117275951e-20 0.9992925578334735 0.008605185381776946 0.1964188918098915 0.0694043261798066 0.14593389736953225 0.11030211095445679 2.6839226215141298e-09 8.57123000919375 -1.2425164048362785 down YEAANWKYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEAANWKYK 9 1 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 7058900.0 2043600.0 2811900.0 2203400.0 False True 2679179.3902505497 2392375.480700351 1975413.304505254 1.0 0.8929508376356323 0.7373202823572477 21.353359752505295 -6.965772295676489 0.3445520503170504 1.0160146065602533 0.609048669013922 0.9999281769705723 0.000913978391515496 0.0776999803253425 0.01394205186309504 0.00216772753806954 0.013426628744208144 1.0820011050671106e-07 6.965772295676489 -0.40696593754633137 YEAANWKYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YEAANWKYK 9 1 G3V5Z7;P60900;G3V295;P60900-2;G3V3I1;P60900-3 G3V5Z7 PSMA6 Proteasome subunit alpha type;Proteasome subunit alpha type-6 0 16876800.0 8471900.0 5881500.0 2523400.0 False True 10967041.556115378 5554189.354745989 2064167.092270477 1.0 0.5064437228879555 0.1882154892646931 23.386671064341876 -8.355784482921408 0.2883011370966684 1.1718207894914303 1.6797437226771187e-23 0.999023508385834 0.01043637679502791 0.1174550834447631 0.07186446655663273 0.10187433211879876 0.09888741912644847 4.407735415316619e-09 8.355784482921408 -1.1718207894914303 down YEAQK(ub)LER ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEAQKLER 8 1 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 1 2367760.0 528980.0 1132700.0 706080.0 True False 693497.9026496069 963705.5752300175 633021.6147976167 1.0 1.3896301222369152 0.9127952837046341 19.403531993839927 -6.689475013337177 1.868124970021528 1.244392485470315 0.914447209904506 0.36801976157741123 0.16480366074996794 0.41780943424069994 2.8265687585486243 0.07058203753455196 0.18393285823409108 2.044207543886981e-07 6.689475013337177 -0.329945275565809 YEAQK(ub)LER ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEAQKLER 8 1 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 1 2827060.0 745460.0 827900.0 1253700.0 True False 721795.7803441731 1158484.787441466 925318.3598061921 1.0 1.6050035466944224 1.2819669842971007 19.461231183626058 -10.084152833079347 4.525405514632209 0.9999704648316253 1.4434852655124257 0.7153436103673199 0.13187912442947644 91655231.81209186 2.035438504057716 30361.91337337901 0.04514573206026393 8.238481426297769e-11 10.084152833079347 0.4435148006808004 YEAQK(ub)LER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEAQKLER 8 1 O00154-4;O00154-6;O00154-7;O00154;O00154-5;O00154-2;O00154-3;K7EKP8 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 1 3278860.0 745460.0 1410100.0 1123300.0 True False 619883.0194774537 1402503.511417064 1358176.836447622 1.0 2.2625293278711527 2.1910211987941404 19.241636459060334 -10.29623695346043 5.729628032406734 0.9998861155232703 2.2267752633326565 0.9974582267359455 0.029193071449994522 4.247291089827657e-05 5.216790371478313e-06 0.02826862900522131 0.009422023295867547 5.0554875655720695e-11 10.29623695346043 1.2268891478093862 YEDICPSTHNMDVPNIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEDICPSTHNMDVPNIK 17 0 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 0 15301300.0 7137300.0 2147000.0 6017000.0 False True 6910730.318260506 3004308.2964570937 4440967.193869236 1.0 0.4347309413187036 0.6426190850096821 22.720406750394684 -10.124434730627803 5.221201125622072 1.0000123738431896 0.5386750131637595 0.86782774947877 0.08486997927107139 1.2224840741170002e-05 2.0500942717299215e-06 0.08217720634757429 0.027391668025599628 7.508708927381263e-11 10.124434730627803 -0.4613373606794301 YEDICPSTHNMDVPNIK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEDICPSTHNMDVPNIKR 18 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 24715200.0 4795400.0 7645800.0 12274000.0 True False 6286815.838719659 6505076.4430949725 11004004.220521685 1.0 1.034717193882327 1.7503302948289805 22.583898071830195 -6.917000379236232 0.8466636448209669 0.9824404048831268 1.8581310556162243 0.9933066876487924 0.028292188749872844 0.09996878887584008 0.11499266708675218 0.023997175389405444 0.0699461723728646 1.2105970764279705e-07 6.917000379236232 0.8756906507330975 YEDICPSTHNMDVPNIK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 YEDICPSTHNMDVPNIKR 18 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 71147900.0 7148500.0 12368000.0 51631400.0 True False 10844797.125352873 10160833.768374944 41426431.15915348 1.0 0.9369316595716701 3.819936019117142 23.370499728841367 -6.901899199593572 0.9491766078519797 0.886301254709308 4.1345114009799655 0.9874879123305441 0.15038590173494235 0.11002099774053761 0.16963755329041652 0.11839085312196429 0.31107653100610794 1.25343206466105e-07 6.901899199593572 3.2482101462706576 up YEDICPSTHNMDVPNIK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEDICPSTHNMDVPNIKR 18 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 24992800.0 4795400.0 6629400.0 13568000.0 True False 6568388.970812282 6336491.187505833 10363517.8417314 1.0 0.9646948765767489 1.5777868649045295 22.647108133353086 -6.893247418896176 1.0029907133170624 0.969576069252144 1.6339962103402996 0.9828960812450513 0.036757920811854375 0.1165474505214703 0.20678135213853888 0.02779861409206579 0.07016256515013491 1.2786526442905903e-07 6.893247418896176 0.6644201410881556 YEDICPSTHNMDVPNIK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEDICPSTHNMDVPNIKR 18 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 20370500.0 7099400.0 4933200.0 8337900.0 True False 5903465.6567464825 4906623.872436466 10081316.33990619 1.0 0.8311429519081176 1.7076945858718189 22.493130713275143 -6.856774368474429 1.2018724000948098 0.9090559300098603 1.7476104189856405 0.9496028742958927 0.08524454980649326 0.15016301891787776 0.41401192781379975 0.055385794698224876 0.12885762249660665 1.3906749489666185e-07 6.856774368474429 0.8385544889757802 YEDICPSTHNMDVPNIK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YEDICPSTHNMDVPNIKR 18 1 I3L397;I3L504;P63241;P63241-2;F8WCJ1;C9J7B5;C9J4W5;Q9GZV4;Q6IS14 I3L397 EIF5A;EIF5A2;EIF5AL1 Eukaryotic translation initiation factor 5A;Eukaryotic translation initiation factor 5A-1;Eukaryotic translation initiation factor 5A-2;Eukaryotic translation initiation factor 5A-1-like 1 61044700.0 7148500.0 14719000.0 39177200.0 True False 9253874.16800136 13899874.710959133 32047351.59201832 1.0 1.5020600516725213 3.4631280921058676 23.141626050933816 -6.945420994677689 0.6070382251714068 0.9782089373903112 4.0885876057657216 0.9987911754933847 0.0369496986738684 0.08537822607017215 0.04398540212554542 0.03766458082814107 0.16519206262379 1.1339110964563208e-07 6.945420994677689 3.1103786683754104 up YEDKDGK(ub)QPVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YEDKDGKQPVGR 12 2 O43488;H3BLU7;A0A499FJT0;Q8NHP1 O43488 AKR7A2;AKR7L Aflatoxin B1 aldehyde reductase member 2;Aflatoxin B1 aldehyde reductase member 4 1 7575300.0 1096600.0 1709000.0 4769700.0 True False 1663622.3721986385 1404015.5975220536 3826966.7043662234 1.0 0.8439508995460975 2.300381846457448 20.66589656074532 -6.880384509420861 1.077619070505725 0.9027758932551148 2.404376123217108 0.9739956880613049 0.10528609820196042 0.12729155384461588 0.27021427664738346 0.0752344785685834 0.18212030695925085 1.3170901158283045e-07 6.880384509420861 1.5016002299619933 up YEDKDGK(ub)QPVGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEDKDGKQPVGR 12 2 O43488;H3BLU7;A0A499FJT0;Q8NHP1 O43488 AKR7A2;AKR7L Aflatoxin B1 aldehyde reductase member 2;Aflatoxin B1 aldehyde reductase member 4 1 5569300.0 1319200.0 1419600.0 2830500.0 True False 1096973.2504690504 1411952.3330314616 3422344.4632466803 1.0 1.2871346976124811 3.119806669655193 20.065096915588374 -6.934541932363825 0.7085272338370665 0.9762672551479136 3.5435981636166236 0.9973579011431972 0.048263508641807604 0.09034722210803071 0.0666252436709659 0.04522541580273831 0.16188461989420586 1.1626742860841947e-07 6.934541932363825 2.56733090846871 up YEDKDGK(ub)QPVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YEDKDGKQPVGR 12 2 O43488;H3BLU7;A0A499FJT0;Q8NHP1 O43488 AKR7A2;AKR7L Aflatoxin B1 aldehyde reductase member 2;Aflatoxin B1 aldehyde reductase member 4 1 3935600.0 1096600.0 1039300.0 1799700.0 True False 1419570.3172176396 981462.041381875 1472173.0664814066 1.0 0.6913796586741419 1.0370554023465837 20.43702288283777 -6.67130797974165 1.9332326622505702 0.8032279369458489 1.0356521970734747 0.28471366714663227 0.1310561737646652 0.4580750995131741 3.3019732961616337 0.05455803537971721 0.14549089598210435 2.1315328015005727e-07 6.67130797974165 0.23242426012762574 YEDQLK(ub)QQQLLNEENLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEDQLKQQQLLNEENLR 17 1 Q9NVI7-2;H0Y2W2;Q9NVI7-3;Q9NVI7;Q5T9A4;Q5T9A4-2;Q5T9A4-3 Q9NVI7-2 ATAD3A;ATAD3B ATPase family AAA domain-containing protein 3A;ATPase family AAA domain-containing protein 3B 1 26618400.0 6809400.0 10816000.0 8993000.0 True False 8927189.342323413 9202294.96043778 8062490.626947324 1.0 1.0308165994430187 0.9031387503705572 23.089774594597287 -6.842975309073663 1.2686647193336151 1.0163919465475286 0.8986901693087979 0.9294228913694867 0.014451866156070603 0.16535557916232388 0.5157160090309703 0.00892805663175069 0.02058602617665258 1.4355710474954163e-07 6.842975309073663 -0.11770177723873076 YEDQLK(ub)QQQLLNEENLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEDQLKQQQLLNEENLR 17 1 Q9NVI7-2;H0Y2W2;Q9NVI7-3;Q9NVI7;Q5T9A4;Q5T9A4-2;Q5T9A4-3 Q9NVI7-2 ATAD3A;ATAD3B ATPase family AAA domain-containing protein 3A;ATPase family AAA domain-containing protein 3B 1 26434500.0 10485000.0 9229600.0 6719900.0 True False 10152159.414198834 12915027.41172815 4959756.597321232 1.0 1.2721458445249747 0.48854203278018904 23.275283292587947 -6.81287717104248 1.4021874385909743 1.1478199104712343 0.47388135002397036 0.8672742058692586 0.1183441467136416 0.20289072463472857 0.7856177533621247 0.06635071497321365 0.15330837486227541 1.5385897290696133e-07 6.81287717104248 -0.673938560447264 down YEDQLK(ub)QQQLLNEENLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEDQLKQQQLLNEENLR 17 1 Q9NVI7-2;H0Y2W2;Q9NVI7-3;Q9NVI7;Q5T9A4;Q5T9A4-2;Q5T9A4-3 Q9NVI7-2 ATAD3A;ATAD3B ATPase family AAA domain-containing protein 3A;ATPase family AAA domain-containing protein 3B 1 24421100.0 6809400.0 8932300.0 8679400.0 True False 9327019.19711582 8537641.450833904 6629504.477854031 1.0 0.9153665571390681 0.7107849075623285 23.15298465612018 -6.956178800618065 0.4863061618361904 1.0046306769934221 0.6128997478066988 0.9996011749124795 0.002424609254718007 0.08109545963471727 0.02639789949996055 0.0029224432935698766 0.016873693324180865 1.1061682767135884e-07 6.956178800618065 -0.39173092918672336 YEDQLK(ub)QQQLLNEENLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEDQLKQQQLLNEENLR 17 1 Q9NVI7-2;H0Y2W2;Q9NVI7-3;Q9NVI7;Q5T9A4;Q5T9A4-2;Q5T9A4-3 Q9NVI7-2 ATAD3A;ATAD3B ATPase family AAA domain-containing protein 3A;ATPase family AAA domain-containing protein 3B 1 22045600.0 10485000.0 8320500.0 3240100.0 True False 8718742.064257115 8275675.815010069 3917589.9294702606 1.0 0.9491823194238747 0.44932971988362874 23.055688568022223 -6.926466724219315 0.7752447902869559 1.0086791523390735 0.3553731859596343 0.9957971049245026 0.016108776905077244 0.09451439618792686 0.08697520917961915 0.014378389374063438 0.04613787557250009 1.1844951199114178e-07 6.926466724219315 -0.6533059663794392 down YEDQLK(ub)QQQLLNEENLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YEDQLKQQQLLNEENLR 17 1 Q9NVI7-2;H0Y2W2;Q9NVI7-3;Q9NVI7;Q5T9A4;Q5T9A4-2;Q5T9A4-3 Q9NVI7-2 ATAD3A;ATAD3B ATPase family AAA domain-containing protein 3A;ATPase family AAA domain-containing protein 3B 1 24469000.0 12726000.0 11743000.0 0.0 True False 16474057.866963053 11089491.727073384 0.0 1.0 0.6731487661769214 0.0 23.973692625680044 -7.483974603036324 0.7221079002463264 0.9926032569957475 3.863473505675335e-17 0.9871199272007077 0.04724923376804763 0.11829456191094471 0.1417590090190363 0.04158205607528376 0.07520000709874106 3.281144802504967e-08 7.483974603036324 -0.9926032569957475 down YEEEEEQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEEEEEQSR 9 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 2699150.0 922150.0 0.0 1777000.0 False True 892876.8530093891 0.0 1311550.3911426994 1.0 0.0 1.4689040114795178 19.76810168471734 -6.723428026680815 1.7472678759730256 0.39384394604165185 1.4670225927555702 0.5285312316372086 0.42063567276603825 0.34869179884834306 2.0822857297838735 0.19102863262117112 0.477578620710653 1.890479504360939e-07 6.723428026680815 1.0731786467139184 YEEIVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEEIVK 6 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 149557300.0 3074300.0 75545000.0 70938000.0 False True 4030437.071563548 64273980.472103655 63598016.245345235 1.0 15.947148989270666 15.779434119950999 21.942504866337003 -9.999358647767584 7.937214497974319 0.9999998302586225 15.863291554610832 0.999904515486738 0.06846930868512499 2.0549103663870524e-07 2.5887905345059047e-08 0.06629512306530863 0.02209837435531856 1.001477859048679e-10 9.999358647767584 14.86329172435221 YEEIVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEEIVK 6 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 155095000.0 52155000.0 13257000.0 89683000.0 False True 50499368.07320361 18550589.23434172 66192331.86767057 1.0 0.3673429973905987 1.3107556469165818 25.589761998940137 -6.725979161597673 1.7376105433624645 0.6175833074876038 1.3098245317527266 0.5406605509634699 0.26604835602477855 0.3438245236631767 2.0317615852070428 0.12142247310354755 0.30271513927218213 1.8794069927118148e-07 6.725979161597673 0.6922412242651228 YEEIVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEEIVK 6 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 150999300.0 3074300.0 76975000.0 70950000.0 False True 4210951.78983363 73573989.97771466 54193071.26111754 1.0 17.47205706684699 12.869553954988081 22.005714927859895 -9.604133531766358 9.326554153121696 1.0000065857587097 15.170805510917537 0.9266850525166829 1.8789640272748627 0.0 0.0 1.819299150656832 0.6064330321459496 2.488092191298804e-10 9.604133531766358 14.170798925158827 YEEIVK(ub)EVSTYIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEEIVKEVSTYIK 13 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 299475000.0 162693000.0 85023000.0 51759000.0 True False 213292098.52125332 72337899.81705822 46403475.18738648 1.0 0.33914945897468474 0.21755834139708013 27.66825528063604 -13.99999999999999 0.23807587499183855 5.3337729605589725 0.16280626147900246 0.9995218232844318 0.007517735833036353 13.556315884724288 0.15444143684757972 27.899814546158435 0.0600934024436645 1.0000000000000246e-14 13.99999999999999 -5.17096669907997 YEEIVK(ub)EVSTYIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEEIVKEVSTYIK 13 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 274309000.0 89502000.0 102956000.0 81851000.0 True False 86660808.00091782 144066867.7084471 60411767.62263433 1.0 1.6624223917566208 0.697105981541212 26.368876352165454 -6.722039431902226 1.7519697856640228 1.4021447474647786 0.698444047946302 0.522022364985933 0.2786847756650672 0.35142535275938 2.1091352283935363 0.12624898959080907 0.31617534348436105 1.8965337170263554e-07 6.722039431902226 -0.7037006995184766 YEEIVK(ub)EVSTYIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YEEIVKEVSTYIK 13 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 544603000.0 161728000.0 144825000.0 238050000.0 True False 245353199.90054825 118979847.22711024 190999313.15897834 1.0 0.4849329345422748 0.7784667705022728 27.870284846280658 -10.19672563096464 5.596997589999127 1.0000117564766378 0.6316998525222551 0.6773221788384715 0.1198346867240454 1.758059312428646e-05 2.523036050766244e-06 0.11603313904764562 0.03867647883167319 6.357324340956471e-11 10.19672563096464 -0.3683119039543826 YEEIVK(ub)EVSTYIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEEIVKEVSTYIK 13 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 344834000.0 162693000.0 99135000.0 83006000.0 True False 222844998.713009 94754887.90439406 63401692.362231515 1.0 0.42520536001090237 0.28451027722584615 27.73146534215893 -13.999999999999988 0.19767441008089864 4.167359726429749 0.1910138731935512 0.9994869826858617 0.00701012612533271 12.485885643096161 0.1409857803722922 15.275890537664706 0.0911660689192447 1.0000000000000286e-14 13.999999999999988 -3.9763458532361975 YEEIVK(ub)EVSTYIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEEIVKEVSTYIK 13 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 253035000.0 89502000.0 101130000.0 62403000.0 True False 74424878.61088601 100585192.61726673 75451178.78112784 1.0 1.351499585819335 1.0137897459746978 26.14928162759973 -10.326586375874433 4.196469028468155 0.9997273235845209 1.182644665900864 0.2805758580950174 0.13786946480227266 0.00035224614212201816 5.652524965387128e-05 0.1336898923360122 0.04449717842569621 4.714261011113605e-11 10.326586375874433 0.18291734231634316 YEEIVK(ub)EVSTYIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YEEIVKEVSTYIK 13 1 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 1 501360000.0 161728000.0 182763000.0 156869000.0 True False 209360084.13548627 172592078.3884113 128320451.61186405 1.0 0.8243791031184304 0.6129174629525949 27.641411168373107 -6.968651988144296 0.2885828281057725 1.0420248310258335 0.38875142773272986 0.999969869134154 0.0008686480254174366 0.07674270308516043 0.010588484754060733 0.0037227359770906593 0.019207946637037312 1.074850373869373e-07 6.968651988144296 -0.6532734032931037 YEFSSHIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEFSSHIAR 9 0 Q9UKT9;Q9UKT9-7;Q9UKT9-3;Q9UKT9-4;Q9UKT9-2;Q9UKT9-6;Q9UKT9-8;Q9UKT9-5;Q9UKT9-15;Q9UKT9-13;Q9UKT9-9;Q9UKT9-10;Q9UKT9-11;Q9UKT9-16;Q9UKT9-12 Q9UKT9 IKZF3 Zinc finger protein Aiolos 0 3236820.0 1407700.0 591420.0 1237700.0 False True 1845508.3321861918 503182.4413371035 1109634.6768567443 1.0 0.2726524895940366 0.6012623500552119 20.815586820468553 -10.559267196352549 6.420061651481974 1.0008336993606244 0.43695741982641934 0.7965144307988284 0.1341544137628434 0.0016029938203114132 0.00011004410876211374 0.13006695429098963 0.04329815086030929 2.758879954209238e-11 10.559267196352549 -0.563876279534205 YEFSSHITR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEFSSHITR 9 0 Q13422-4;Q13422-3;Q13422-7;Q13422;Q13422-2;A0A0A0MRA0;A0A0A0MST1;A0A087WU46;Q13422-6;Q13422-5;R9R4D9 Q13422-4 IKZF1 DNA-binding protein Ikaros 0 7241400.0 2590600.0 1812700.0 2838100.0 False True 3396301.687406086 1542252.2258492566 2544440.636977557 1.0 0.45409753543630177 0.7491798053196108 21.69553318592807 -10.092243299638952 5.321241434842194 1.0000058868721848 0.6016386703776216 0.7084550851053493 0.12046683222725355 8.41340556462774e-06 1.4352685434781645e-06 0.1166432323275231 0.03888050291537026 8.086427559347836e-11 10.092243299638952 -0.3983672164945632 YEFSSHITR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEFSSHITR 9 0 Q13422-4;Q13422-3;Q13422-7;Q13422;Q13422-2;A0A0A0MRA0;A0A0A0MST1;A0A087WU46;Q13422-6;Q13422-5;R9R4D9 Q13422-4 IKZF1 DNA-binding protein Ikaros 0 3713880.0 1077900.0 431880.0 2204100.0 False True 1043682.6545126302 604331.9362244476 1626780.0884173475 1.0 0.5790380185121053 1.5586922723909855 19.99325167743995 -6.789935044237063 1.4966004215073234 0.7647041502407746 1.5690913427865987 0.801108777858348 0.17894971520119066 0.2354501008897977 1.041829432461028 0.09411659552762079 0.22035968001360987 1.6220526834268826e-07 6.789935044237063 0.804387192545824 YEFSSHITR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEFSSHITR 9 0 Q13422-4;Q13422-3;Q13422-7;Q13422;Q13422-2;A0A0A0MRA0;A0A0A0MST1;A0A087WU46;Q13422-6;Q13422-5;R9R4D9 Q13422-4 IKZF1 DNA-binding protein Ikaros 0 4929900.0 2590600.0 927700.0 1411600.0 False True 3548414.82833263 886711.1465063433 1078209.152814567 1.0 0.2498893701565894 0.30385656834863595 21.758743247450962 -10.292282576518678 8.544304450018096 1.0000006490250586 0.27687296925261307 0.9958401136996774 0.022032016403027477 2.723911732208381e-07 2.2563935816736738e-08 0.02133242706329719 0.007110802717691172 5.1017294462803175e-11 10.292282576518678 -0.7231276797724455 YEFSSHITR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEFSSHITR 9 0 Q13422-4;Q13422-3;Q13422-7;Q13422;Q13422-2;A0A0A0MRA0;A0A0A0MST1;A0A087WU46;Q13422-6;Q13422-5;R9R4D9 Q13422-4 IKZF1 DNA-binding protein Ikaros 0 2333520.0 1077900.0 755890.0 499730.0 False True 896321.6090665472 751817.8705375828 604221.2325095435 1.0 0.8387813737086464 0.6741120892296631 19.773656952874227 -6.970860923141584 0.23672504101566763 1.0615823274174307 0.4465675110308766 0.9999883382075665 0.00045430584744744133 0.07602434411939832 0.00802391381870825 0.004029162238728479 0.016148798098614716 1.0693972842250434e-07 6.970860923141584 -0.6150148163865541 YEHANDDK(ub)SSLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEHANDDKSSLK 12 1 Q6P996;Q6P996-5;Q6P996-4;Q6P996-3;H3BND4 Q6P996 PDXDC1 Pyridoxal-dependent decarboxylase domain-containing protein 1 1 4744490.0 750690.0 1595500.0 2398300.0 True False 726859.7568569303 2232591.470422583 1770113.2825422268 1.0 3.0715574075481933 2.4352886039481794 19.47131750625052 -10.040404908389373 5.246731076938145 0.9999838136356631 2.753423005752222 0.9101191114021374 0.25975565135929757 4.918255757661961e-05 8.995372389644087e-06 0.25150963788461733 0.08383577598111906 9.111609350582328e-11 10.040404908389373 1.7534391921165589 YEHANDDK(ub)SSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YEHANDDKSSLK 12 1 Q6P996;Q6P996-5;Q6P996-4;Q6P996-3;H3BND4 Q6P996 PDXDC1 Pyridoxal-dependent decarboxylase domain-containing protein 1 1 15536980.0 904780.0 2174200.0 12458000.0 True False 1372617.4082782082 1786197.0228978654 9995670.839464622 1.0 1.301307277705625 7.28219734004616 20.388498126275078 -6.917361882752754 0.8440548669534851 0.8550750850859047 8.190499515672071 0.9934162959544266 0.2347424533361403 0.09974917150362 0.11383904269600038 0.19947836504815747 0.5832659308335184 1.209589803651398e-07 6.917361882752754 7.3354244305861664 up YEIASVPVSLQTLK(ub)PVTDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEIASVPVSLQTLKPVTDR 19 1 Q5T0D5;A0A0A0MRV3;Q9P2S5 Q5T0D5 WRAP73 WD repeat-containing protein WRAP73 1 9797600.0 2053600.0 4990000.0 2754000.0 True False 2692289.487090689 4245511.450867657 2469042.4982333975 1.0 1.576914916179906 0.9170791291472395 21.360402112681015 -6.6756112025322 1.9169150220976723 1.3664269402720075 0.9196322270637738 0.30447090721198133 0.24474422355166406 0.44830654306538525 3.1808397958300922 0.10258072608323852 0.27213678254855744 2.1105167218599785e-07 6.6756112025322 -0.4467947132082337 YEIASVPVSLQTLK(ub)PVTDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEIASVPVSLQTLKPVTDR 19 1 Q5T0D5;A0A0A0MRV3;Q9P2S5 Q5T0D5 WRAP73 WD repeat-containing protein WRAP73 1 12913500.0 2053600.0 4971400.0 5888500.0 True False 2812871.416453289 4751747.109778633 4497757.577464282 1.0 1.6892869976154283 1.5989915326934647 21.423612174203907 -10.555495441340145 5.972711725489729 0.9985741282231572 1.6441392651543025 0.9854762169929023 0.03686296919103167 0.0007011942766453246 5.21845219489582e-05 0.03575760849753751 0.011897472147385192 2.7829445854399154e-11 10.555495441340145 0.6455651369311454 YEIASVPVSLQTLK(ub)PVTDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEIASVPVSLQTLKPVTDR 19 1 Q5T0D5;A0A0A0MRV3;Q9P2S5 Q5T0D5 WRAP73 WD repeat-containing protein WRAP73 1 27942900.0 13435000.0 8298600.0 6209300.0 True False 11171797.771415759 8253893.794656875 7507635.921440594 1.0 0.7388151811855516 0.6720168118912504 23.413358027938795 -13.999999999994094 0.19145667960064572 2.4072255923010553 0.6247910767687485 0.9994886714115273 0.0032001381617109814 12.374794264481379 0.13875945359512343 6.4997532276341285 0.04541154108364849 1.0000000000136e-14 13.999999999994094 -1.782434515532307 YEIMDGAPVK(ub)GESIPIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEIMDGAPVKGESIPIR 17 1 O75436 O75436 VPS26A Vacuolar protein sorting-associated protein 26A 1 10806700.0 4528200.0 3486400.0 2792100.0 True False 4384454.769611368 4878537.701335815 2060765.2487954616 1.0 1.1126897089117973 0.47001630922928306 22.06396601630779 -6.861645057722719 1.1774838513992687 1.0614219175720663 0.437915856358942 0.9556039634722462 0.05903926921576321 0.1451114863296912 0.38138693679173497 0.03908187228520431 0.0913988710090363 1.3751654176522614e-07 6.861645057722719 -0.6235060612131242 down YEIMDGAPVK(ub)GESIPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEIMDGAPVKGESIPIR 17 1 O75436 O75436 VPS26A Vacuolar protein sorting-associated protein 26A 1 6957600.0 4106700.0 2850900.0 0.0 True False 5625057.96939459 2724937.8113344163 0.0 1.0 0.4844283963224105 0.0 22.423436533516455 -7.977820683028654 0.5835094065417585 1.013125263677565 2.100795287859712e-18 0.9893916213502844 0.04205513868404812 0.1117626283643725 0.16375559673380943 0.04577948382454164 0.0764661161897502 1.0523963107624993e-08 7.977820683028654 -1.013125263677565 YEIMDGAPVK(ub)GESIPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEIMDGAPVKGESIPIR 17 1 O75436 O75436 VPS26A Vacuolar protein sorting-associated protein 26A 1 9932700.0 4528200.0 3703900.0 1700600.0 True False 3765398.9332731613 3683946.3555334145 2056187.5973140094 1.0 0.9783681412824584 0.5460743028167324 21.844371291742068 -6.917296818717051 0.8445290963570131 1.0104989014855943 0.48051971471496097 0.993396545556672 0.016989414860982082 0.09978866892123996 0.11404765678043263 0.014432317408496643 0.0421751949063417 1.2097710325019674e-07 6.917296818717051 -0.5299791867706334 YEIMDGAPVK(ub)GESIPIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YEIMDGAPVKGESIPIR 17 1 O75436 O75436 VPS26A Vacuolar protein sorting-associated protein 26A 1 31468100.0 7993100.0 9859000.0 13616000.0 True False 10347225.51755638 9310337.983242493 11138027.711958012 1.0 0.8997907668529525 1.0764264964612842 23.302740642693973 -6.752756498340097 1.6392848044679846 0.9412747673775713 1.0768611874254805 0.6609471262766903 0.04211578436162964 0.29523270222533576 1.5616902213260528 0.020286859317020532 0.049116264558543565 1.767028286228431e-07 6.752756498340097 0.13558642004790922 YEITEQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEITEQR 7 0 Q02878 Q02878 RPL6 60S ribosomal protein L6 0 6633860.0 1793200.0 700560.0 4140100.0 False True 1736275.8475480536 980297.2613721386 3055683.6096622883 1.0 0.5645976489026797 1.7599067648020823 20.727564740767317 -6.808139743340586 1.4223306115784597 0.7621806269566159 1.779940988032112 0.8549111946273282 0.18814463071608484 0.20935221975284038 0.8350724710747914 0.10402183107642639 0.24083396029368215 1.5554650476332702e-07 6.808139743340586 1.0177603610754962 YEITFTLPPVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEITFTLPPVHR 12 0 H7BYU9;Q9GZN8;Q9GZN8-2 H7BYU9 C20orf27 UPF0687 protein C20orf27 0 2105200.0 2105200.0 0.0 0.0 False True 2759937.586785798 0.0 0.0 1.0 0.0 0.0 21.39620421159837 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 YEITFTLPPVHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEITFTLPPVHR 12 0 H7BYU9;Q9GZN8;Q9GZN8-2 H7BYU9 C20orf27 UPF0687 protein C20orf27 0 8692200.0 4076800.0 2039400.0 2576000.0 False True 3947384.2155274968 2853743.0553305023 1901268.3216564949 1.0 0.7229453479863882 0.48165271426521744 21.91246551897293 -6.972743943904359 0.1810138199500158 1.184044401435859 0.014022041209257574 0.9999966306468259 0.00038870026176068226 0.07542195867091524 0.005715101849494725 0.009209037103118503 0.026995389211689653 1.0647706123097996e-07 6.972743943904359 -1.1700223602266016 down YEITFTLPPVHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YEITFTLPPVHR 12 0 H7BYU9;Q9GZN8;Q9GZN8-2 H7BYU9 C20orf27 UPF0687 protein C20orf27 0 8660300.0 2514600.0 6145700.0 0.0 False True 3814832.041884638 5048951.818426731 0.0 1.0 1.3235056649918464 0.0 21.863188109300296 -6.876515004191836 1.3473976113327062 1.1691956586157854 1.0064545625527716e-20 0.9269003489608172 0.1523140855867227 0.1515985006442427 0.5533137323502904 0.09160610114213442 0.1874315166000418 1.328877645699311e-07 6.876515004191836 -1.1691956586157854 down YEITFTLPPVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEITFTLPPVHR 12 0 H7BYU9;Q9GZN8;Q9GZN8-2 H7BYU9 C20orf27 UPF0687 protein C20orf27 0 8845000.0 2105200.0 2995200.0 3744600.0 False True 2883549.3308908553 2862862.160198129 2860202.6024577967 1.0 0.9928257961564558 0.9919034752820248 21.45941427312126 -13.999999905625655 0.2892053539055004 1.061543987742639 0.9916501229496482 0.9996231377336326 7.001763348462996e-05 15.918718114301578 0.17052371902185873 0.5826070902751412 0.00034959444174606616 1.000000217304983e-14 13.999999905625655 -0.06989386479299076 YEITFTLPPVHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEITFTLPPVHR 12 0 H7BYU9;Q9GZN8;Q9GZN8-2 H7BYU9 C20orf27 UPF0687 protein C20orf27 0 8025000.0 4076800.0 2215800.0 1732400.0 False True 3390039.832862509 2203863.0455981367 2094636.8302874216 1.0 0.6500994543586885 0.6178797104335896 21.692870794407206 -13.99999999999992 0.33747169063422483 4.985124808677949 0.6126609205644176 0.9997301318219205 0.0028426312023906715 19.474099798990036 0.18618937195975624 55.29318942635146 0.010045472634366854 1.0000000000001841e-14 13.99999999999992 -4.372463888113532 YEITFTLPPVHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YEITFTLPPVHR 12 0 H7BYU9;Q9GZN8;Q9GZN8-2 H7BYU9 C20orf27 UPF0687 protein C20orf27 0 8169600.0 2514600.0 3400600.0 2254400.0 False True 3255199.270176431 3211353.6206323532 1844122.3320973972 1.0 0.986530578958473 0.5665159577150698 21.634314431392745 -6.91372812256898 0.8699522090955157 1.0115218715303693 0.5076725031552306 0.992254231523154 0.017711731049101304 0.10200432149000291 0.12577332215009024 0.014773603347568505 0.041916857147030175 1.2197529508269984e-07 6.91372812256898 -0.5038493683751387 YEK(ub)AEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEKAEIK 7 1 P16422;B5MCA4 P16422 EPCAM Epithelial cell adhesion molecule 1 17016300.0 5541100.0 8005600.0 3469600.0 True False 7264435.760088731 6811195.685584383 3110599.074753301 1.0 0.9376083581061482 0.42819555124200137 22.79241931518857 -6.929718396405208 0.7491006389275311 1.0078280912366893 0.3243619771239101 0.9964825980276334 0.01518959298812594 0.09278433019598543 0.07839860946506193 0.013815336071392228 0.04616466613208661 1.1756596246363871e-07 6.929718396405208 -0.6834661141127791 down YEK(ub)AEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEKAEIK 7 1 P16422;B5MCA4 P16422 EPCAM Epithelial cell adhesion molecule 1 8771000.0 2821600.0 4023300.0 1926100.0 True False 2732029.8524657553 5629824.671232326 1421596.6282385779 1.0 2.0606746541042393 0.5203444709637911 21.38154181714288 -6.72140256230691 1.75427078825632 1.644316713203628 0.5225488714658928 0.5191919343817633 0.4462580850533694 0.35256674836720714 2.12121359196084 0.20192660011714506 0.5060765115313376 1.8993169223491146e-07 6.72140256230691 -1.1217678417377352 YEK(ub)AEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEKAEIK 7 1 P16422;B5MCA4 P16422 EPCAM Epithelial cell adhesion molecule 1 12711300.0 5541100.0 4002100.0 3168100.0 True False 7589794.412597058 3825273.988825096 2419860.0290676043 1.0 0.5040023195458561 0.3188307742633021 22.855629376711462 -13.999999999999998 0.13679291952147501 3.3634544982013677 0.08056922991696626 0.9996160240560067 0.00563511393621919 11.932098251777358 0.11563381704889393 7.542431564083102 0.21257704715432169 1.0000000000000041e-14 13.999999999999998 -3.282885268284401 YEK(ub)AEIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEKAEIK 7 1 P16422;B5MCA4 P16422 EPCAM Epithelial cell adhesion molecule 1 7356600.0 2821600.0 3349500.0 1185500.0 True False 2346285.4180741906 3331455.5786763076 1433382.5688673148 1.0 1.4198850459594705 0.6109156873351845 21.161947092577158 -6.7656539373188 1.5912024692847733 1.2421693895483616 0.6071057580544804 0.7136255917240819 0.1767780959044145 0.273513081181029 1.3660083506470941 0.0876079021086061 0.2093761464849497 1.7153235994277333e-07 6.7656539373188 -0.6350636314938812 YEK(ub)LVSSGFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEKLVSSGFR 10 1 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 7212700.0 1729200.0 1271400.0 4212100.0 True False 1674307.4925162245 1779076.6502634122 3108824.6497085877 1.0 1.062574621576671 1.8567823793444933 20.675133077612532 -6.922600326788648 0.8052028481889713 0.9840641256553241 1.9928438586999961 0.994873376506312 0.0279227197942206 0.09666573446712796 0.09786132185076483 0.024395733418137572 0.07499707118710504 1.1950874154820478e-07 6.922600326788648 1.0087797330446722 YEK(ub)LVSSGFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEKLVSSGFR 10 1 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 6084000.0 1729200.0 2478200.0 1876600.0 True False 1437906.4165487261 2464849.4447158123 2268988.3835819503 1.0 1.714193230065669 1.5779805677674026 20.45553835304681 -10.150730618323502 4.403130202479675 0.9998868042041295 1.6460868989182322 0.9677393750886876 0.05560858667350266 8353064.919102217 9628357.34646835 7752.88595043089 0.019036297766088662 7.067558007443747e-11 10.150730618323502 0.6462000947141028 YEK(ub)LVSSGFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YEKLVSSGFR 10 1 H3BP11;O75444;O75444-1 H3BP11 MAF Transcription factor Maf 1 13422230.0 1483300.0 671330.0 11267600.0 True False 1920161.0902142306 633969.8953535011 9217012.415339166 1.0 0.33016495260966344 4.800124563669204 20.872795918970745 -6.868750996944852 1.1407409702706248 0.623912336750503 5.05570264151737 0.9634176042776215 0.37647991838836825 0.13805495223452327 0.33655174385163944 0.2563281523597652 0.6055605359529009 1.3528479972523847e-07 6.868750996944852 4.431790304766867 up YEK(ub)THVCNLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEKTHVCNLK 10 1 Q9UL63;F8WEY7 Q9UL63 MKLN1 Muskelin 1 8347600.0 2848600.0 3966100.0 1532900.0 True False 3734542.1858816445 3374373.3397367136 1374290.2126150965 1.0 0.9035574300093485 0.3679942933328135 21.83249996450984 -6.937494822455041 0.682476267300424 1.0063513811016003 0.23362867576326538 0.997816942777978 0.012989087474239899 0.08892848375706242 0.0599560352070568 0.012415619894534435 0.046626455832309885 1.1547957517796066e-07 6.937494822455041 -0.7727227053383349 down YEK(ub)THVCNLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEKTHVCNLK 10 1 Q9UL63;F8WEY7 Q9UL63 MKLN1 Muskelin 1 7232100.0 2848600.0 3231400.0 1152100.0 True False 3901804.400520475 3088626.0631891782 879997.708244306 1.0 0.7915891587946273 0.2255360899503112 21.89571002603273 -6.984414228600773 0.5282244164781091 1.0086791557552695 2.1285342695960907e-10 0.9994555126929574 0.007635388699122812 0.07749476169803492 0.03052893624129482 0.008679875182515184 0.0439280238693319 1.0365392965256193e-07 6.984414228600773 -1.008679155542416 down YELGRPAANTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YELGRPAANTK 11 1 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 0 3441940.0 1079300.0 339440.0 2023200.0 False True 1045038.2122789499 474980.1621562151 1493263.2253010194 1.0 0.4545098510038307 1.4289077736637115 19.995124265369498 -6.754818193358728 1.6322314185276574 0.6811056659679712 1.4315505841270992 0.6693277388550224 0.2292943221937965 0.29172769252987674 1.5305662460199978 0.11091205892265797 0.267893601364065 1.7586596792491742e-07 6.754818193358728 0.7504449181591281 YELGRPAANTK(ub)IGPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YELGRPAANTKIGPR 15 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 20532300.0 3203200.0 5000100.0 12329000.0 True False 4859488.5852878755 4107793.089040384 9892167.746007338 1.0 0.8453138672815792 2.0356396712106544 22.212373061284516 -6.874217019466277 1.1115006477807259 0.9098262931669431 2.111188244424326 0.9687158751677954 0.09346897521249319 0.1328780887863166 0.3042669273527842 0.06507890212623543 0.1553149754108173 1.335927778880773e-07 6.874217019466277 1.201361951257383 up YELGRPAANTK(ub)IGPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YELGRPAANTKIGPR 15 2 P62241;Q5JR95 P62241 RPS8 40S ribosomal protein S8 1 19015700.0 3203200.0 8493100.0 7319400.0 True False 4146605.5445117163 8020451.518965075 5987344.303386118 1.0 1.9342209990483972 1.4439146041539281 21.983499383376966 -10.258558701369656 4.959025267620157 0.999854977354742 1.6890678016016751 0.7247806084108055 0.200166747520941 0.00032100798923700367 4.7995090287161364e-05 0.19385086699954734 0.0646035399675056 5.513676717893882e-11 10.258558701369656 0.6892128242469331 YEQGTGCWQGPNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEQGTGCWQGPNR 13 0 K7ELL7;P14314-2;P14314;A0A0C4DGP4 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 14327960.0 857260.0 6973500.0 6497200.0 False True 1123876.1617176482 5933080.982490104 5824932.06954321 1.0 5.279123434224664 5.18289493803376 20.10005164516891 -10.119694210528584 4.4334469806149075 0.9994716776279895 5.231009186334437 0.9996121959898293 0.03928511975906267 1446086.6826012668 1100303.5419108272 6632.43242450449 0.01344834127456104 7.591118823449675e-11 10.119694210528584 4.231537508706447 YEQGTGCWQGPNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEQGTGCWQGPNR 13 0 K7ELL7;P14314-2;P14314;A0A0C4DGP4 K7ELL7 PRKCSH Glucosidase 2 subunit beta 0 16198560.0 857260.0 6375000.0 8966300.0 False True 1174212.188580417 6093331.420694136 6848644.606745016 1.0 5.189293281021693 5.832544299361086 20.163261706691802 -9.672644174558135 0.5100268326073659 5.018761355365446e-23 5.815536760195368 0.9987757754077836 0.07496800730136727 0.9683760362238921 0.22561391110641066 1.8703686039030947 0.12753592994566482 2.1249847880099386e-10 9.672644174558135 5.815536760195368 YESASMSSTCEPCK(ub)SR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YESASMSSTCEPCKSR 16 1 A0A5H1ZRS1;Q15154-5;Q15154;H0YBA1 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 7082200.0 2833900.0 1784000.0 2464300.0 True False 4299233.485841436 1465631.2615443799 1977230.0248589383 1.0 0.3409052488940432 0.4599029178969933 22.035648032685277 -9.982859018114882 6.153395028451638 1.0000003303607217 0.4004040833986226 0.9713069098211088 0.04858059493979297 2.2018623990866815e-07 3.633665484412216e-08 0.04703798472059426 0.015679319595866274 1.0402578024109055e-10 9.982859018114882 -0.599596246962099 YESHPVCADLQAK(ub)ILQCYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YESHPVCADLQAKILQCYR 19 1 C9JRZ6;Q9NX63 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 29492500.0 6392300.0 13605000.0 9495200.0 True False 8380367.2031212635 11575187.031874632 8512727.788389878 1.0 1.3812267113502448 1.0157941271617927 22.998582029300778 -10.58887080482422 7.041883246572438 0.9997472684251111 1.1985104192560185 0.28235732898319066 0.14918722777472723 0.0005926894383512538 3.4603128912409414e-05 0.14463139229562227 0.048149970719864245 2.5770876824636574e-11 10.58887080482422 0.19876315083090745 YESHPVCADLQAK(ub)ILQCYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YESHPVCADLQAKILQCYR 19 1 C9JRZ6;Q9NX63 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 230588000.0 39518000.0 39271000.0 151799000.0 True False 59951695.152786545 32262783.224276576 121795861.1141348 1.0 0.5381463049886256 2.031566593800872 25.837297211077782 -6.823650761770172 1.355941723950781 0.7519316152108155 2.066808126853515 0.8925742209655436 0.20461942577367684 0.18879002367007175 0.6810128942923291 0.11855124833025009 0.2730208330533266 1.5008912931973784e-07 6.823650761770172 1.3148765116426993 up YESHPVCADLQAK(ub)ILQCYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YESHPVCADLQAKILQCYR 19 1 C9JRZ6;Q9NX63 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 30359300.0 6392300.0 11808000.0 12159000.0 True False 8755706.055412142 11286283.516165692 9287294.622465508 1.0 1.2890203765108506 1.0607133866405642 23.06179209082367 -10.024055789495977 4.497846960944333 0.999992870542693 1.1748668814313763 0.4388944066041005 0.09320593837169745 64391545.199726544 4.891815061830163 4754.541170036448 0.03190687182888828 9.461156154886464e-11 10.024055789495977 0.17487401088868326 YESHPVCADLQAK(ub)ILQCYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YESHPVCADLQAKILQCYR 19 1 C9JRZ6;Q9NX63 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 167980000.0 39518000.0 30606000.0 97856000.0 True False 51156830.01623803 28902749.19516377 80047212.0873503 1.0 0.5649831935635878 1.5647414443377743 25.60842353317023 -6.788434786511032 1.5024751371527674 0.7563718964041534 1.5749354823735737 0.7962373420434046 0.1847553139342089 0.23769777339849146 1.0600535823396013 0.09679619568808007 0.2268949729700055 1.627665706936717e-07 6.788434786511032 0.8185635859694204 YESLK(ub)GVDPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YESLKGVDPK 10 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 14837500.0 5490000.0 4756900.0 4590600.0 True False 7197443.165235625 4047189.0622509676 4115608.748144597 1.0 0.5623092769664787 0.5718153868895278 22.77905306088552 -10.5382670975941 6.271355706385213 1.0005504705651316 0.5670623319280033 0.9996385400927441 0.0038808531250463687 2.9905347931491712e-05 2.201793569034807e-06 0.003762158970934874 0.0012525399601984683 2.8955622259509744e-11 10.5382670975941 -0.4334881386371283 YESLK(ub)GVDPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YESLKGVDPK 10 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 36507400.0 7977400.0 9665900.0 18864100.0 True False 7724161.803607981 13525544.277002605 13923026.29913054 1.0 1.7510695167836567 1.8025290838194314 22.880946955106506 -11.208062672339794 0.4603997901104697 9.36172855804638e-23 1.8023032874380314 0.9997452446606727 0.005854334620657909 3.2785617674296894 0.22558392927255685 3.3815422963465425 0.011335717047185534 6.193516909788138e-12 11.208062672339794 1.8023032874380314 YESLK(ub)GVDPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YESLKGVDPK 10 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 25277700.0 10028500.0 5046200.0 10203000.0 True False 15213967.681555778 4145666.1838594456 8186372.577866244 1.0 0.2724907973141895 0.5380826848863864 23.858893109715268 -10.329904852059215 5.749049616732207 1.0000835405571917 0.4052867411012968 0.8698823652366536 0.1084274340624297 0.00011611678086951286 1.3534182664526548e-05 0.10499902911627342 0.03499480386631464 4.678376268421559e-11 10.329904852059215 -0.5947967994558949 YESLK(ub)GVDPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YESLKGVDPK 10 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 15419700.0 5490000.0 2853500.0 7076200.0 True False 7519801.36167148 2727422.9347373657 5404947.298913601 1.0 0.3626988006144782 0.7187619777382264 22.84226312240841 -10.687108192267477 6.904458210333601 1.0031748213992102 0.5407303891764884 0.6892768245830732 0.14536218335790185 0.007134900878583688 0.00032333447505703103 0.14135878252209666 0.04691544294279189 2.0553784923987705e-11 10.687108192267477 -0.4624444322227218 YESLK(ub)GVDPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YESLKGVDPK 10 1 A0A3B3ITT5;P47914 A0A3B3ITT5 RPL29 60S ribosomal protein L29 1 31748600.0 7977400.0 16001300.0 7769900.0 True False 6633561.558741499 15915097.820890628 9394550.166041473 1.0 2.399178432273416 1.4162151180554932 22.661352230540782 -10.261982016586488 5.876299138331433 0.9999582075075634 1.9076967751644496 0.5320458187618793 0.401293092618179 0.0002197426553459632 2.7598500771641103e-05 0.38856813144683977 0.1295167887215204 5.4703861438585625e-11 10.261982016586488 0.9077385676568862 YESLTDPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YESLTDPSK 9 0 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF8;Q58FF6 P08238;Q58FF7;P07900;Q58FF8;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB2P;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 2;Putative heat shock protein HSP 90-beta 4 0 84710100.0 1990100.0 45674000.0 37046000.0 False True 2609040.372155814 38859617.23585761 33212835.290324748 1.0 14.894218445438792 12.72990469782629 21.31508783784073 -9.20688461750317 12.459944751488617 0.9999880001294333 13.812061571632542 0.9790460083524442 0.8835773875174073 0.0 0.0 0.8555201267228187 0.28517337557427286 6.210340073979148e-10 9.20688461750317 12.81207357150311 YESLTDPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YESLTDPSK 9 0 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF8;Q58FF6 P08238;Q58FF7;P07900;Q58FF8;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB2P;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 2;Putative heat shock protein HSP 90-beta 4 0 90471700.0 26587000.0 8154700.0 55730000.0 False True 25743010.237988017 11410914.236198708 41132641.135837205 1.0 0.44326262277439643 1.5978178447499225 24.61767742800687 -6.775594219269003 1.5530707261757541 0.682949788752098 1.6057233083429396 0.7514516931871967 0.2350369309052122 0.25749624754976974 1.226419504980983 0.1192360796017485 0.2823968447772325 1.6765085813024517e-07 6.775594219269003 0.9227735195908416 YESLTDPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YESLTDPSK 9 0 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF8;Q58FF6 P08238;Q58FF7;P07900;Q58FF8;Q58FF6 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB2P;HSP90AB4P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 2;Putative heat shock protein HSP 90-beta 4 0 93631100.0 1990100.0 47233000.0 44408000.0 False True 2725893.7504303125 45146089.88135618 33919745.01146877 1.0 16.56194041834146 12.443531596238541 21.37829789936362 -9.734701962839083 8.521613439234452 0.9999999997688109 14.502736007290004 0.9347792646490918 1.681333361054818 0.0 0.0 1.627944026697059 0.5426480088990195 1.8420356757118627e-10 9.734701962839083 13.502736007521193 YESLTDPSK(ub)LDSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YESLTDPSKLDSGK 14 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF8 P08238;Q58FF7;P07900;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 2 1 87152000.0 35366000.0 28927000.0 22859000.0 True False 46365168.48483119 24611204.35656286 20493769.959011346 1.0 0.5308123567935411 0.442007882829458 25.46653806169949 -13.99999999999998 0.23406527339640132 4.018658254688559 0.40046725830470353 0.9995156069989066 0.005387958402732627 13.421324656378326 0.15315887161202 18.872203468867767 0.04495967939549582 1.000000000000045e-14 13.99999999999998 -3.6181909963838557 YESLTDPSK(ub)LDSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YESLTDPSKLDSGK 14 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF8 P08238;Q58FF7;P07900;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 2 1 110644000.0 40726000.0 27923000.0 41995000.0 True False 39433175.42228528 39072799.51652138 30995249.67700487 1.0 0.9908610985064054 0.786019622946424 25.2329065547619 -6.916240000128652 0.8521419098488685 1.005160626379688 0.7556835626810574 0.9930712435312615 0.008223005401225001 0.10043501169473705 0.11744968833531348 0.006947347779888498 0.020118140339747546 1.2127184918906306e-07 6.916240000128652 -0.24947706369863054 YESLTDPSK(ub)LDSGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YESLTDPSKLDSGK 14 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF8 P08238;Q58FF7;P07900;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 2 1 398672000.0 101800000.0 97002000.0 199870000.0 True False 154438042.57689354 79691235.21991485 160365606.89386705 1.0 0.5160078041020054 1.0383815037931616 27.202452933186304 -11.952546318128366 14.410179010365663 0.9021177519847042 0.799475188552825 0.0 0.24333802656320705 0.0 0.0 0.0 0.07076930119556839 1.1154591796879634e-12 11.952546318128366 -0.10264256343187927 YESLTDPSK(ub)LDSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YESLTDPSKLDSGK 14 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF8 P08238;Q58FF7;P07900;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 2 1 112112000.0 35366000.0 34182000.0 42564000.0 True False 48441765.93021379 32671726.215241887 32511259.83309668 1.0 0.6744536576620566 0.67114109506109 25.529748123222383 YESLTDPSK(ub)LDSGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YESLTDPSKLDSGK 14 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF8 P08238;Q58FF7;P07900;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 2 1 109447000.0 40726000.0 45322000.0 23399000.0 True False 33865473.46770956 45077841.39028739 28291622.715247862 1.0 1.3310855208703556 0.8354119939360565 25.013311830196177 -6.726635113586775 1.7350792695688027 1.1999801298127422 0.8358592512880718 0.5438225553304223 0.1392207817414322 0.3425634766884304 2.01870407110797 0.06362191999963497 0.15850377873226779 1.8765705067028337e-07 6.726635113586775 -0.36412087852467034 YESLTDPSK(ub)LDSGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YESLTDPSKLDSGK 14 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF8 P08238;Q58FF7;P07900;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 2 1 470665000.0 101800000.0 96675000.0 272190000.0 True False 131782106.77800088 91294951.26584518 222654212.90524772 1.0 0.692771981704921 1.6895633128731906 26.973579255278754 -6.8239624759966375 1.3547909695195897 0.8350397378317888 1.7132028166610715 0.8932238438810419 0.1361952597408068 0.1883839600639366 0.6783345985611289 0.07897799399799883 0.18185455565841913 1.4998144171856133e-07 6.8239624759966375 0.8781630788292828 YESLTDPSK(ub)LDSGKELK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YESLTDPSKLDSGKELK 17 2 P08238;Q58FF7;Q58FF8 P08238;Q58FF7;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 2 31204400.0 13078700.0 4016700.0 14109000.0 True False 16930634.969719432 3793167.1140369284 11541306.770565184 1.0 0.2240416334544473 0.681681861974279 24.013132745565997 -10.065135176523102 5.712855902984711 1.000002496599993 0.45286174772616233 0.6558644258248941 0.18683084094106872 5.940991926907309e-06 9.720133845352196e-07 0.18089901122915553 0.06029939462683868 8.607258048915765e-11 10.065135176523102 -0.5471407488738307 YESLTDPSKLDSGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YESLTDPSKLDSGK 14 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF8 P08238;Q58FF7;P07900;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 2 0 31096900.0 1356400.0 14136100.0 15604400.0 False True 1778253.5353962868 12027048.982086217 13989806.375974298 1.0 6.763405072835111 7.867160726806397 20.76202960113103 -9.412397367118977 0.5170415886985992 4.456456292536686e-21 7.842149216301411 0.9982092206442104 0.12741667404443144 0.7531850348860659 0.2209372433449636 1.786061739039035 0.21587653766042533 3.869034772242499e-10 9.412397367118977 7.842149216301411 YESLTDPSKLDSGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YESLTDPSKLDSGK 14 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF8 P08238;Q58FF7;P07900;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 2 0 22754700.0 7450000.0 1642700.0 13662000.0 False True 7213503.82792383 2298638.676567333 10083512.34878536 1.0 0.3186577191058233 1.397866084128435 22.78226876184088 -6.736094291266623 1.7011173858376902 0.5927721086079198 1.3979581076915635 0.5872007326120691 0.2863100913672897 0.32494407441052786 1.8447746357734087 0.13323573885583437 0.32834541569432985 1.8361396490604014e-07 6.736094291266623 0.8051859990836436 YESLTDPSKLDSGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YESLTDPSKLDSGK 14 1 P08238;Q58FF7;P07900;P07900-2;G3V2J8;Q58FF8 P08238;Q58FF7;P07900;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AA1;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Heat shock protein HSP 90-alpha;Putative heat shock protein HSP 90-beta 2 0 32747700.0 1356400.0 17069100.0 14322200.0 False True 1857897.735331732 16314930.722034559 10939591.334967963 1.0 8.781393298335384 5.8881558047729 20.82523966265392 -9.91614780305304 6.3644835678374125 0.9999991991122201 7.334774551554603 0.8647175717774453 1.1811592606544856 1.3418721082085177e-05 2.2813437919227715e-06 1.143652672604672 0.38121751214421457 1.21297596918325e-10 9.91614780305304 6.334775352442383 YESLTDPSKLDSGK(ub)ELHINLIPNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YESLTDPSKLDSGKELHINLIPNK 24 2 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 40014400.0 23793000.0 7495000.0 8726400.0 True False 36095720.50129689 6157458.691297714 7001623.215083012 1.0 0.17058694509440478 0.1939737763326112 25.10532446593516 -10.099412775498934 7.168414120860712 1.000000286300596 0.1822803625405763 0.9993869032940553 0.009547633872365052 4.368804723266219e-08 5.476758508952634e-09 0.00924446005170491 0.003081485581946317 7.954029996909462e-11 10.099412775498934 -0.8177199237600196 YESLTDPSKLDSGK(ub)ELHINLIPNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YESLTDPSKLDSGKELHINLIPNK 24 2 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 51969600.0 23793000.0 15703600.0 12473000.0 True False 30800507.530147064 14829680.855426159 10203041.983787613 1.0 0.48147521078706557 0.3312621382553853 24.876450788027608 -13.999999999999998 0.1737199071788409 3.641374395383676 0.20387132537838426 0.9995070746127472 0.006360426420156803 12.129899955414768 0.13205222263768637 10.801691908986106 0.11844022840222881 1.0000000000000041e-14 13.999999999999998 -3.4375030700052918 YESLTDPSKLDSGK(ub)ELHINLIPNKQDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YESLTDPSKLDSGKELHINLIPNKQDR 27 3 P07900;P07900-2;G3V2J8 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 70028000.0 23542000.0 15946000.0 30540000.0 True False 30475583.082197398 15058591.082339454 24982033.366862323 1.0 0.4941198677552481 0.8197393073491617 24.861150488067597 -10.11595154125003 5.271068274109614 1.0000075076407162 0.6569295875519264 0.5967868823112026 0.13293357955700033 1.1728570173127367e-05 1.967147144280436e-06 0.12871519945981727 0.04290412831452488 7.656820372493864e-11 10.11595154125003 -0.3430779200887898 YESLTDPSKLDSGKELK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 YESLTDPSKLDSGKELK 17 2 P08238;Q58FF7;Q58FF8 P08238;Q58FF7;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 1 56953200.0 31449000.0 17861000.0 7643200.0 True False 41229943.552549176 15196208.421632718 6852354.982751452 1.0 0.36857213743852346 0.16619850507478523 25.297189150261353 -12.586963364457535 0.18112968608124175 2.93764498169153 1.4404626417628297e-15 0.9994632269788077 0.008227145394855718 6.954179037000546 0.12416208445094988 5.026146213779506 0.14746908929396557 2.588431256825825e-13 12.586963364457535 -2.9376449816915287 YESLTDPSKLDSGKELK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YESLTDPSKLDSGKELK 17 2 P08238;Q58FF7;Q58FF8 P08238;Q58FF7;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 1 64948600.0 31449000.0 26231000.0 7268600.0 True False 43076545.177268885 25072027.685682796 5551906.38151599 1.0 0.5820343201272576 0.12888467166224096 25.360399211784244 -7.690972410223976 0.44201130058571136 1.0317996553023392 2.3984704271449866e-20 0.9974230092924086 0.018058200939156232 0.11759795033597045 0.07430421870628476 0.027736617634750497 0.07530738640701337 2.0371714906322812e-08 7.690972410223976 -1.0317996553023392 down YESLTDPSKLDSGKELK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YESLTDPSKLDSGKELK 17 2 P08238;Q58FF7;Q58FF8 P08238;Q58FF7;Q58FF8 HSP90AB1;HSP90AB3P;HSP90AB2P Heat shock protein HSP 90-beta;Putative heat shock protein HSP 90-beta-3;Putative heat shock protein HSP 90-beta 2 1 63480300.0 28665000.0 29231000.0 5584300.0 True False 23836217.57481449 29073526.801100753 6751951.311114084 1.0 1.2197206503023381 0.28326437656989006 24.50665198562424 -6.844876460020199 1.2595828358352539 1.1169197705992113 0.2493738024265981 0.9325102534825022 0.10387680998326405 0.16318302230374565 0.5007958661259575 0.06460906659687687 0.14909803057558865 1.4293004813840662e-07 6.844876460020199 -0.8675459681726132 down YESMINTMLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YESMINTMLK 10 0 Q5TH69 Q5TH69 ARFGEF3 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 0 10169200.0 2385400.0 2467200.0 5316600.0 False True 2309676.7827019463 3452365.826278034 3924022.9654188384 1.0 1.494739806077683 1.6989489589224556 21.1392595436413 -11.206111271351006 0.16494460629765137 1.4553684273599067e-18 1.9263727654743954 0.9995527364011833 0.00620598563010809 3.576504408170642 0.09810121147799748 1.4940327896167807 0.16872624721211216 6.221408649450573e-12 11.206111271351006 1.9263727654743954 YESMINTMLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YESMINTMLK 10 0 Q5TH69 Q5TH69 ARFGEF3 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 0 13906400.0 7321400.0 3223600.0 3361400.0 False True 11107099.066036036 2648323.3938982417 2697017.8166460395 1.0 0.23843520060034815 0.2428192816694275 23.4049787294054 -10.014016204840525 5.068320525138511 1.0000073511542316 0.24062724113087441 0.9999750021841299 0.0017897936287691817 2297451.129769364 1513106.2079317314 178.62839409660054 0.0006126937768355876 9.6824172756018e-11 10.014016204840525 -0.7593801100233571 YESMINTMLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YESMINTMLK 10 0 Q5TH69 Q5TH69 ARFGEF3 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 0 5425300.0 2161400.0 1675700.0 1588200.0 False True 2960527.989638749 1601662.0332011222 1213099.8700057361 1.0 0.5410055364470853 0.4097579466403767 21.49742306278143 -13.999999999999998 0.1755801845099916 3.350473161215389 0.3006018131754094 0.9995041404187255 0.005634786725243982 12.150725099129534 0.1327840545538196 9.734591390782143 0.10180300215991404 1.0000000000000041e-14 13.999999999999998 -3.0498713480399795 YESMINTMLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YESMINTMLK 10 0 Q5TH69 Q5TH69 ARFGEF3 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 0 9889000.0 2385400.0 5073200.0 2430400.0 False True 1983565.791137714 5045869.6646486465 2938585.4031000617 1.0 2.5438378132920345 1.481466062900075 20.919664819075578 -10.491992654227356 5.5585552519656645 0.9984806017222522 2.0126519380959538 0.5478083478312084 0.43371145093462504 0.008175672356281957 0.0007471897546793089 0.42040912065365144 0.1399797688774373 3.2211232737604246e-11 10.491992654227356 1.0141713363737015 YESMINTMLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YESMINTMLK 10 0 Q5TH69 Q5TH69 ARFGEF3 Brefeldin A-inhibited guanine nucleotide-exchange protein 3 0 15775300.0 7321400.0 4936200.0 3517700.0 False True 9477696.626369897 4661496.130731473 2877514.694650018 1.0 0.4918385040687778 0.3036090738169312 23.17610505149785 -13.999999999999998 0.13796490512213172 3.423393100192759 0.06485350052838919 0.9996111707872527 0.005799898603724286 11.932483048398097 0.11622138323388677 7.794343635958518 0.21316606891730394 1.0000000000000041e-14 13.999999999999998 -3.3585395996643697 YESSALPSGQLTSLSEYASR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YESSALPSGQLTSLSEYASR 20 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 12494800.0 1000700.0 5441100.0 6053000.0 False True 1311927.390792584 4629309.089241681 5426693.624475936 1.0 3.528632088735447 4.136428328703062 20.323256444888244 -9.69939948296452 0.3872717707039261 6.956299845743021e-15 4.225575060393248 0.9985606255772504 0.05152609776868358 1.028970485003904 0.16527546474917668 1.4720925541125551 0.15932645600960232 1.9980231554473614e-10 9.69939948296452 4.225575060393241 YESSALPSGQLTSLSEYASR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YESSALPSGQLTSLSEYASR 20 0 Q12931-2;Q12931;I3L0K7 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 15043300.0 1000700.0 5429300.0 8613300.0 False True 1370685.8329006643 5189415.573705824 6579015.936481795 1.0 3.785999277984738 4.799798596122637 20.386466506411136 -9.243448191196459 0.3426465477248553 3.725958968628758e-18 5.089574062319609 0.9982980219626048 0.06627688665503097 0.6434119458664154 0.13045094355883516 1.1272201076749349 0.30158608234919126 5.708891758652133e-10 9.243448191196459 5.089574062319609 YETGQLFLHSIFGYR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YETGQLFLHSIFGYR 15 0 Q9Y2S7 Q9Y2S7 POLDIP2 Polymerase delta-interacting protein 2 0 2591460.0 784720.0 730740.0 1076000.0 False True 1028775.5192392902 621716.440402211 964665.841720819 1.0 0.6043266278944198 0.9376835117870262 19.972496787114057 -10.057245016597136 7.101356600279245 1.000000046236669 0.771005069840723 0.3861924837507943 0.13609237796351728 9.966816078327859e-08 1.3133848882564502e-08 0.13177090485732243 0.04392362611653893 8.765061817625082e-11 10.057245016597136 -0.2289949763959459 YETGQLFLHSIFGYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YETGQLFLHSIFGYR 15 0 Q9Y2S7 Q9Y2S7 POLDIP2 Polymerase delta-interacting protein 2 0 15304400.0 6007200.0 4837200.0 4460000.0 False True 5816504.724175028 6768719.1856647525 3291792.2028680006 1.0 1.1637090497893097 0.5659399173504299 22.471721033126116 -6.833712355620287 1.3112644787239407 1.0872750620422815 0.5486022156813495 0.9130942479730408 0.0743540599123272 0.17627325465419239 0.5914364197820674 0.04450397711853607 0.10241974553539195 1.466518832418907e-07 6.833712355620287 -0.538672846360932 YETGQLFLHSIFGYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YETGQLFLHSIFGYR 15 0 Q9Y2S7 Q9Y2S7 POLDIP2 Polymerase delta-interacting protein 2 0 27634400.0 7284900.0 8274500.0 12075000.0 False True 11051725.89752861 6797850.826036426 9688370.957339484 1.0 0.6150940485735865 0.876638730201045 23.397768350513665 -9.948498047048433 5.371179676477635 1.0000005718158473 0.7458663893863036 0.5572952514293925 0.10677516915787544 7.31217267733605e-07 1.4312280410930188e-07 0.10338484560091225 0.03446153766089771 1.1259055318973958e-10 9.948498047048433 -0.2541341824295438 YETGQLFLHSIFGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YETGQLFLHSIFGYR 15 0 Q9Y2S7 Q9Y2S7 POLDIP2 Polymerase delta-interacting protein 2 0 6355020.0 784720.0 1013400.0 4556900.0 False True 1074852.190260628 968624.6371343426 3480654.072301435 1.0 0.9011700826505944 3.2382629945215564 20.03570684863695 -6.8970263199570345 0.9798827485763381 0.8947464181951398 3.4692833890075243 0.9850276828894037 0.13204953486182902 0.11362714068429049 0.19002442755439278 0.10161021921397376 0.26063871554265516 1.2675750434872114e-07 6.8970263199570345 2.5745369708123844 up YETGQLFLHSIFGYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YETGQLFLHSIFGYR 15 0 Q9Y2S7 Q9Y2S7 POLDIP2 Polymerase delta-interacting protein 2 0 11858700.0 6007200.0 2223600.0 3627900.0 False True 4995252.964082526 2211621.025449956 4386477.116485649 1.0 0.44274454994616325 0.8781291253968175 22.252126308560392 -9.908062685419662 6.663843778800543 1.0000000179647375 0.6604368376714903 0.44782625393965503 0.17774500862209108 4.7365873119738217e-08 8.081606315178904e-09 0.1721008722596963 0.057366954855400415 1.2357690515039944e-10 9.908062685419662 -0.33956318029324717 YETGQLFLHSIFGYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YETGQLFLHSIFGYR 15 0 Q9Y2S7 Q9Y2S7 POLDIP2 Polymerase delta-interacting protein 2 0 22751400.0 7284900.0 6722100.0 8744400.0 False True 9430446.65684734 6348009.22579919 7153008.925120865 1.0 0.6731398264354714 0.7585016050037404 23.168894672606115 -9.894235632295864 6.3390146914857635 1.0000000278058285 0.7158207157195747 0.9366180116976105 0.03484880017156462 1.36952572122551e-08 2.379540865457081e-09 0.03374220919447554 0.011247401891631556 1.2757464476580735e-10 9.894235632295864 -0.2841793120862538 YEVLK(ub)TENPGDASDLQGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEVLKTENPGDASDLQGR 18 1 O60437;K7EKI8 O60437 PPL Periplakin 1 26588300.0 7935000.0 13901000.0 4752300.0 True False 10402861.842649318 11827024.985673606 4260577.5832805205 1.0 1.136901091696282 0.40955822039404016 23.310477134715505 -6.858021985251025 1.195680715413584 1.073921745857128 0.3756428503577874 0.9511913138337049 0.06972299913147807 0.14885378902407836 0.4055071057435134 0.04551575225636273 0.1060225391892256 1.3866856290314783e-07 6.858021985251025 -0.6982788954993406 down YEVLK(ub)TENPGDASDLQGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEVLKTENPGDASDLQGR 18 1 O60437;K7EKI8 O60437 PPL Periplakin 1 23662000.0 10753000.0 9081100.0 3827900.0 True False 10411651.900894614 12707230.587310905 2825258.155461531 1.0 1.2204816976467534 0.27135541817516706 23.311695647369678 -6.845530210966898 1.2563539564494963 1.1173581126980612 0.23654038980067832 0.9335535788841531 0.10454434122348502 0.16245033289334676 0.49566766394120393 0.06517895304056394 0.1504690090557571 1.4271505493785386e-07 6.845530210966898 -0.8808177228973828 down YEVLK(ub)TENPGDASDLQGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YEVLKTENPGDASDLQGR 18 1 O60437;K7EKI8 O60437 PPL Periplakin 1 31060000.0 19811000.0 11249000.0 0.0 True False 30054735.37810256 9241528.061161844 0.0 1.0 0.30748991614463145 0.0 24.84108898187946 -8.712696717802316 0.49364442292581245 1.073256210858968 3.069233801593878e-20 0.994784927881504 0.03020145398548561 0.32742783592077995 0.19084040785060294 0.11063058092745835 0.06186865658178598 1.937774703712868e-09 8.712696717802316 -1.073256210858968 YEVLK(ub)TENPGDASDLQGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEVLKTENPGDASDLQGR 18 1 O60437;K7EKI8 O60437 PPL Periplakin 1 17653000.0 7935000.0 6503100.0 3214900.0 True False 10868783.935312072 6215771.5391240725 2455606.832943857 1.0 0.571892088031061 0.22593206816502515 23.373687196238397 -7.881865459339275 0.30086384703249097 1.114241689731526 4.95269903920873e-13 0.9993038948353129 0.008353230303164408 0.1112881440317721 0.05184003881965116 0.04823664545980347 0.08607051983013775 1.3126064701305925e-08 7.881865459339275 -1.1142416897310308 down YEVLK(ub)TENPGDASDLQGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEVLKTENPGDASDLQGR 18 1 O60437;K7EKI8 O60437 PPL Periplakin 1 22947900.0 10753000.0 10306000.0 1888900.0 True False 8941595.93867017 10250479.532419158 2283860.2567131803 1.0 1.146381429302614 0.25541975642581377 23.092100922803954 -6.864737227476616 1.1616640307049575 1.0806523483689143 0.20822378240659134 0.9591374688669643 0.07885778718873528 0.14199571861063184 0.36147460286251537 0.05283710062331247 0.12406415573100418 1.3654090357655833e-07 6.864737227476616 -0.872428565962323 down YEVSVYALK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEVSVYALK 9 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 45373000.0 22633000.0 22740000.0 0.0 False True 29672082.178283814 19347280.639825743 0.0 1.0 0.6520365009633698 0.0 24.822602832785154 -7.529753841791081 0.7035503464266437 0.9940356156747812 5.327697080261882e-15 0.9870619035973927 0.04714666835248515 0.12000770859131464 0.14356688204035709 0.041912527839219706 0.07610116785672658 2.95288244685833e-08 7.529753841791081 -0.9940356156747758 down YEVSVYALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEVSVYALK 9 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 46778000.0 17991000.0 10914000.0 17873000.0 False True 17419885.552775502 15272017.11575811 13191525.121493239 1.0 0.876700198143657 0.7572681853464553 24.05423180979093 -6.971514809099449 0.21900295843888948 1.0557748836073448 0.5748249664836192 0.9999919064161961 0.00028186996737874544 0.07581415955216288 0.0072452404992677496 0.0033335664886578816 0.012130742710231669 1.0677883811763153e-07 6.971514809099449 -0.4809499171237256 YEVSVYALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEVSVYALK 9 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 78449000.0 22633000.0 30242000.0 25574000.0 False True 31001031.733827118 28905808.44307951 19533947.913062997 1.0 0.9324144012774458 0.6301063809998398 24.885812894308046 -6.9423175118363725 0.6376436828833305 1.003304709693766 0.5427086478587532 0.9984519075703737 0.006327747380879569 0.08672523926175177 0.049914102154601306 0.006273645371502449 0.025765134585101407 1.1420430840629232e-07 6.9423175118363725 -0.4605960618350128 YEVSVYALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEVSVYALK 9 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;H0Y7Z1 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 37359600.0 17991000.0 12823000.0 6545600.0 False True 14960313.636437738 12753919.953833781 7914254.696565078 1.0 0.8525168832537036 0.5290166295236557 23.834637085225207 -6.958199450150799 0.4601075324108733 1.0094193351625989 0.3590709066250819 0.9996974793987365 0.003421275790997148 0.08035069361136138 0.023556066102865803 0.004394302262112519 0.0267240589509856 1.101033542719462e-07 6.958199450150799 -0.650348428537517 YEWDVAEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEWDVAEAR 9 0 P13639 P13639 EEF2 Elongation factor 2 0 41805100.0 2459100.0 17850000.0 21496000.0 False True 3223903.913958273 15186849.578755034 19271800.124192107 1.0 4.710701678484205 5.977783655633337 21.62037731538557 -9.16936023251753 0.38383807136907494 3.181548394115758e-18 6.2228896764721995 0.9979201768892169 0.09632780570088186 0.5809252538693552 0.1458691490384432 1.2270978805223218 0.3322225775987124 6.770796600520101e-10 9.16936023251753 6.2228896764721995 YEWDVAEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEWDVAEAR 9 0 P13639 P13639 EEF2 Elongation factor 2 0 27008400.0 5863600.0 2523800.0 18621000.0 False True 5677463.227572369 3531566.501443135 13743601.481974237 1.0 0.622032474696133 2.420729281913971 22.436815026078303 -6.8518442028643065 1.2262838833725846 0.7979546224626147 2.4951806067147033 0.9429286627979225 0.18499055164719205 0.15544219311659474 0.4489055239759644 0.11798987503359114 0.2733556990449683 1.406552014706658e-07 6.8518442028643065 1.6972259842520887 up YEWDVAEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEWDVAEAR 9 0 P13639 P13639 EEF2 Elongation factor 2 0 43467100.0 2459100.0 17885000.0 23123000.0 False True 3368295.7246787483 17094781.56221403 17661823.633133475 1.0 5.075202107987252 5.243548986429324 21.683587376908463 -10.108774704288972 0.700520087524478 3.1790618891944236e-20 5.214849412168289 0.999819750794786 0.026340570222730415 1.3896903644818246 0.35052110283791915 2.9664509243427726 0.02616211968999083 7.784402719702855e-11 10.108774704288972 5.214849412168289 YEWDVAEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEWDVAEAR 9 0 P13639 P13639 EEF2 Elongation factor 2 0 8773200.0 5863600.0 1449500.0 1460100.0 False True 4875843.201523894 1441691.2557967755 1765400.1592603684 1.0 0.2956803974635997 0.36207074064822486 22.21722030151258 -10.150066594940634 5.2696096042082115 1.0000222836236152 0.32887556907999915 0.9927140001222282 0.027103744109713935 7.0959460026173616e-06 1.144527147418454e-06 0.026243956696137435 0.008747695796214332 7.07837235933797e-11 10.150066594940634 -0.6711467145436161 YEYHWADGTNIK(ub)KPIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEYHWADGTNIKKPIK 16 2 D6RCK3;Q9H8S9-2;Q9H8S9;Q7L9L4;Q7L9L4-2 D6RCK3 MOB1B;MOB1A MOB kinase activator 1A;MOB kinase activator 1B 1 8588700.0 4375900.0 2247300.0 1965500.0 True False 3638754.7352391677 2235193.3488458763 2376476.962554794 1.0 0.6142742535514589 0.6531017162382594 21.795013381103097 -9.91851608433447 6.930521044977878 1.0000000117112389 0.6336879852973494 0.9916441073689717 0.0158512452649433 2.859197492550657e-09 4.4548906586401776e-10 0.01534790280369368 0.005115967410646769 1.2063794084462054e-10 9.91851608433447 -0.3663120264138895 YEYK(ub)DGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YEYKDGSR 8 1 Q5QPM9;Q5QPM7;Q92530 Q5QPM9 PSMF1 Proteasome inhibitor PI31 subunit 1 7108780.0 1259650.0 786730.0 5062400.0 True False 1651413.3484679523 669352.950649521 4538591.409969769 1.0 0.4053212669441557 2.7483073297065856 20.65526984108793 -6.839410833998563 1.285115144699232 0.6836183508256626 2.824488360288016 0.9234476345769418 0.27513655693454026 0.16947913820611807 0.5439581261211242 0.16789581192391748 0.3867433550595644 1.4474019920310195e-07 6.839410833998563 2.140870009462353 up YEYK(ub)DGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEYKDGSR 8 1 Q5QPM9;Q5QPM7;Q92530 Q5QPM9 PSMF1 Proteasome inhibitor PI31 subunit 1 9983760.0 1259650.0 1935410.0 6788700.0 True False 1725376.64576129 1849897.1866550017 5185348.877665245 1.0 1.0721700628089639 3.0053431466132468 20.71847990261082 -6.914793245834491 0.8624450148764387 0.9488315694249192 3.2825957914846624 0.9926083890802371 0.07985177291587628 0.1013332605430185 0.12220182530798235 0.06696648971078709 0.19161660767753003 1.2167651270129046e-07 6.914793245834491 2.3337642220597434 up YEYK(ub)SDQWKPLNLEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YEYKSDQWKPLNLEEK 16 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 21358300.0 5988700.0 6422900.0 8946700.0 True False 5798591.996548645 8987597.464981025 6603290.874753172 1.0 1.5499620373929557 1.138774874777099 22.46727119953033 -10.710571102131622 6.419797477191465 0.9952252739928885 1.3443684560850273 0.4832586198053681 0.16786645619860996 0.011573314352780922 0.000521768339934412 0.16397278567925763 0.054178665770339446 1.947282217314282e-11 10.710571102131622 0.3491431820921388 YEYK(ub)SDQWKPLNLEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YEYKSDQWKPLNLEEK 16 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 81219100.0 9115100.0 25108000.0 46996000.0 True False 13828273.103071153 20627281.230300635 37707220.000921465 1.0 1.491674417807056 2.726820602967914 23.7211176658776 -6.955357919694845 0.4965535291336047 0.9745075198300952 3.2969491330273453 0.9995574235950854 0.015282164343354016 0.08140297086971984 0.027590697193151582 0.018040367114679844 0.10187854434356579 1.1082610758924e-07 6.955357919694845 2.32244161319725 YEYK(ub)SDQWKPLNLEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YEYKSDQWKPLNLEEK 16 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 15279400.0 3921600.0 6470200.0 4887600.0 True False 5371521.497255164 6184325.169909823 3733249.5432817186 1.0 1.1513172148840882 0.69500783813104 22.356899362495326 -6.817323130439859 1.3833816791852533 1.0817873868650827 0.6856041579838179 0.8781182560576856 0.06625387483299988 0.19698661648724278 0.7414556381284587 0.03764171937902435 0.08682758279912048 1.5229192264422148e-07 6.817323130439859 -0.3961832288812648 YEYK(ub)SDQWKPLNLEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YEYKSDQWKPLNLEEK 16 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 20115100.0 5988700.0 9089700.0 5036700.0 True False 4979869.394393569 9040731.981935818 6089850.682930418 1.0 1.8154556406868914 1.2228936545577858 22.247676474964607 -10.043728606620267 5.251457012025648 0.999995062656642 1.519174647623461 0.5058126805869165 0.2419124178350023 1.398412099082853e-05 2.546934949052516e-06 0.23423291735434074 0.07807689712574571 9.042143464949759e-11 10.043728606620267 0.5191795849668192 YEYK(ub)SDQWKPLNLEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YEYKSDQWKPLNLEEK 16 2 Q04637-7;E9PGM1;Q04637-8;E7EX73;E7EUU4;Q04637-9;Q04637;Q04637-3;Q04637-4;Q04637-6;Q04637-5;C9JF13;C9J6B6;C9K073;C9J2Z7 Q04637-7 EIF4G1 Eukaryotic translation initiation factor 4 gamma 1 1 86171100.0 9115100.0 19363000.0 57693000.0 True False 11799676.635482876 18285432.028555032 47193465.98016985 1.0 1.5496553501787331 3.9995558724256988 23.49224398797005 -6.942397522969873 0.6368676286797718 0.9732292952570861 4.709581481345495 0.9984613794492909 0.051145928877971474 0.08668968069313186 0.0497550181861261 0.0507426356889274 0.2087326032390972 1.1418327020554144e-07 6.942397522969873 3.736352186088409 YFAGNLASGGAAGATSLCFVYPLDFAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YFAGNLASGGAAGATSLCFVYPLDFAR 27 0 P12236;V9GYG0;P12235 P12236 SLC25A6;SLC25A4 ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed;ADP/ATP translocase 1 0 82570000.0 29082000.0 24945000.0 28543000.0 False True 44119520.17899031 20493369.853825435 22901463.53915867 1.0 0.46449666203723505 0.5190778015320378 25.39491376522344 -10.866096162760266 11.286601061293963 1.0156576427683606 0.4917872317846369 0.9914234126385564 0.022282656890322838 0.007764387172215838 9.211621213831939e-05 0.01908099763699372 0.007191696587122856 1.3611432607561103e-11 10.866096162760266 -0.5238704109837237 YFAGNLASGGAAGATSLCFVYPLDFAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFAGNLASGGAAGATSLCFVYPLDFAR 27 0 P12236;V9GYG0;P12235 P12236 SLC25A6;SLC25A4 ADP/ATP translocase 3;ADP/ATP translocase 3, N-terminally processed;ADP/ATP translocase 1 0 56840700.0 29082000.0 7960700.0 19798000.0 False True 37647222.29192355 7517680.046982294 16194967.144634603 1.0 0.19968750917899883 0.43017694689546604 25.16604008731589 -10.250126501529332 5.0228058356135135 1.0001172904161826 0.3149322280492615 0.9217458400483443 0.09409691891912046 265892694.84114316 72.85997308644906 360689.2945509276 0.032211878177121206 5.621775499613388e-11 10.250126501529332 -0.6851850623669211 YFCENCQSK(ub)QNATR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YFCENCQSKQNATR 14 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;Q86UV5-7;Q86UV5-4 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 21818100.0 2256300.0 5041800.0 14520000.0 True False 3422972.0576251945 4142051.3982368056 11650115.635657929 1.0 1.21007455757921 3.403508833706519 21.706818084724773 -6.925501210927177 0.782841320004427 0.96050471533597 3.8062207925776166 0.995577745114526 0.07227880630649056 0.0950418242403359 0.08962441382897277 0.06416538007435507 0.20359718243936611 1.1871313910046098e-07 6.925501210927177 2.8457160772416463 up YFCENCQSK(ub)QNATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFCENCQSKQNATR 14 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;Q86UV5-7;Q86UV5-4 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 30312300.0 2256300.0 5771000.0 22285000.0 True False 2920824.8283222327 5449838.776883289 18229358.66340952 1.0 1.8658560842259622 6.241168072335494 21.477944406817223 -6.9395694749437045 0.6635559145890225 0.950506455173689 7.406258846115464 0.9981069759008745 0.09981044220077158 0.08796357130917123 0.05550804714719765 0.09684399470848587 0.377294256347908 1.1492923741483964e-07 6.9395694749437045 6.455752390941775 YFCK(ub)AGVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFCKAGVK 8 1 Q9BSJ8-2;Q9BSJ8 Q9BSJ8-2 ESYT1 Extended synaptotagmin-1 1 5900000.0 2160300.0 2076500.0 1663200.0 True False 2796550.9358793255 1960940.949609799 1360514.6658731322 1.0 0.7011997973829918 0.4864973666018147 21.415217176876805 -7.711860554358384 0.14190397442991348 1.3413443039850796 4.4583119101286987e-13 0.999978386188014 0.000978944255279659 0.1345007044894449 0.017277742149730446 0.06139673279997394 0.08898773937562963 1.9415091678785534e-08 7.711860554358384 -1.3413443039846338 down YFDGNLEK(ub)LFAECHVINPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFDGNLEKLFAECHVINPSK 20 1 Q9Y4X5 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 7971890.0 1582500.0 5772900.0 616490.0 True False 2074672.8249517991 4911605.822587956 552701.5285896537 1.0 2.3674122317103503 0.26640418765908047 20.984452411308663 -6.731057134048233 1.7193837783482646 1.8219293906147256 0.2674120467736771 0.5641657525135835 0.5747805793865283 0.3342554541155814 1.9363627670700998 0.26486402629907563 0.6564549227562189 1.857560065830172e-07 6.731057134048233 -1.5545173438410484 YFDGNLEK(ub)LFAECHVINPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFDGNLEKLFAECHVINPSK 20 1 Q9Y4X5 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 11853500.0 1582500.0 6784700.0 3486300.0 True False 2167593.015454484 6484929.519997407 2662907.7426023157 1.0 2.9917652777810306 1.2285090990865635 21.047662472831554 -6.616842073934236 2.1282735845281167 2.3245198421699986 1.2351194588102425 0.07223811503768973 0.8572225320627281 0.594010222949691 5.108168199108609 0.33145729157459836 0.9508753465519294 2.4163393480074673e-07 6.616842073934236 -1.089400383359756 YFDGNLEK(ub)LFAECHVINPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YFDGNLEKLFAECHVINPSK 20 1 Q9Y4X5 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 14608100.0 9306600.0 2471400.0 2830100.0 True False 7738850.252285679 2458086.077665511 3421860.8250960726 1.0 0.3176293632170376 0.44216656396541876 22.883687812885416 -10.294736197449739 6.700380210470791 1.000011666149345 0.37989796359738925 0.9706376844307106 0.05084209930468164 8.860544499994014e-06 9.326844357508239e-07 0.04922857584103899 0.01640921699110463 5.072987620860084e-11 10.294736197449739 -0.6201137025519557 YFDGNLEK(ub)LFAECHVINPSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFDGNLEKLFAECHVINPSK 20 1 Q9Y4X5 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 25438800.0 14481100.0 6952800.0 4004900.0 True False 18746069.415156245 6565870.567997602 3276049.293744171 1.0 0.35025318761964463 0.1747592639924547 24.160084794235203 -13.999999999999774 0.18370626902589912 4.410678883679745 0.04056242267652012 0.9994941339885344 0.007983645512854638 12.254937995040656 0.13589967979720513 14.933149536437428 0.12701663507318667 1.0000000000005194e-14 13.999999999999774 -4.370116461003225 YFDK(ub)ASYR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YFDKASYR 8 1 P29401;E9PFF2 P29401 TKT Transketolase 1 12997200.0 1971500.0 3497400.0 7528300.0 True False 2990909.6359562455 2873261.644689079 6040328.205228894 1.0 0.9606648125196359 2.019562253774911 21.5121528924437 -6.89827028928758 0.9721189849832067 0.9538612193801174 2.1268955065122968 0.9856865028659622 0.05864235821969751 0.1126903939262133 0.1846789642760883 0.04538587111367736 0.11709653040652279 1.263949465881098e-07 6.89827028928758 1.1730342871321793 up YFDK(ub)ASYR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFDKASYR 8 1 P29401;E9PFF2 P29401 TKT Transketolase 1 12382100.0 1971500.0 2600000.0 7810600.0 True False 2552145.61407494 2455307.714416314 6389150.9435237385 1.0 0.9620562795772426 2.5034429494492514 21.28327921453615 -6.901256069394529 0.9532817168021659 0.9381047118553432 2.6694353678815816 0.9871812400798572 0.08127386068472783 0.11048698738485534 0.17224645680532716 0.06378824052116465 0.16703895157724105 1.2552895996237038e-07 6.901256069394529 1.7313306560262385 up YFDLGLPNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFDLGLPNR 9 0 P48735;P48735-2 P48735 IDH2 Isocitrate dehydrogenase [NADP], mitochondrial 0 3757040.0 611040.0 1600200.0 1545800.0 False True 801079.3573197766 1361456.397530747 1385855.444360633 1.0 1.6995275001041852 1.7299852151943846 19.611585641840747 -11.26291319501175 0.5247247896518913 2.0054857643330057e-12 1.7279416158976706 0.9998670793032395 0.0038872558315647854 3.51575758979099 0.2572890622868238 4.100154549337581 0.005928099666503473 5.458669558219647e-12 11.26291319501175 1.727941615895665 YFDPANGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFDPANGK 8 0 P13639 P13639 EEF2 Elongation factor 2 0 12028350.0 724550.0 6208500.0 5095300.0 False True 949892.0665521803 5282216.000543448 4568087.23356885 1.0 5.560859161311124 4.80905925464734 19.857404067989552 -10.155441112489072 5.407983568720796 0.9998866737174814 5.184959207980305 0.9763681912956768 0.30692102667014903 0.0004193772478878624 6.549392989952596e-05 0.2971824419089651 0.09905833540731897 6.991315280295118e-11 10.155441112489072 4.185072534262824 YFDPANGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YFDPANGK 8 0 P13639 P13639 EEF2 Elongation factor 2 0 9476100.0 2823500.0 1204100.0 5448500.0 False True 2733869.538005762 1684903.40929855 4021374.3985036523 1.0 0.6163071740898117 1.4709459769748445 21.38251296758528 -6.784638505125688 1.517565158113844 0.7840523722991893 1.4787558015052347 0.7835332050028767 0.16261318903786437 0.24343333942600093 1.107527556294437 0.08436912188871865 0.19833767598958563 1.6419559238474415e-07 6.784638505125688 0.6947034292060453 YFDPANGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFDPANGK 8 0 P13639 P13639 EEF2 Elongation factor 2 0 10990050.0 724550.0 5334000.0 4931500.0 False True 992435.7152275171 5098326.24282078 3766781.2674305993 1.0 5.137185375933375 3.7954914455764626 19.920614129512444 -10.645547372705558 9.65141102433641 0.9986851494696629 4.466338410754733 0.8989864989108196 0.5477442533939527 0.015490561338119975 0.0005688981818195572 0.5300989932388805 0.17678369761463256 2.261791810773621e-11 10.645547372705558 3.46765326128507 YFDPANGK(ub)FSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFDPANGKFSK 11 1 P13639 P13639 EEF2 Elongation factor 2 1 91436200.0 28337700.0 39652000.0 23446500.0 True False 37150999.1226772 33736076.16228538 21020481.094709247 1.0 0.9080799159905412 0.5658119994376737 25.146897674704853 -6.946521618546625 0.595809185235252 1.0038934544832654 0.45260329454799025 0.9988992730879289 0.006198167006354819 0.08491328784092193 0.04197991246240436 0.0063880121009814985 0.028724737164068183 1.1310410863548088e-07 6.946521618546625 -0.5512901599352751 YFDPANGK(ub)FSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YFDPANGKFSK 11 1 P13639 P13639 EEF2 Elongation factor 2 1 123477000.0 43033900.0 38661700.0 41781400.0 True False 41667812.40006588 54099518.42810209 30837597.9248675 1.0 1.298352740688075 0.7400819997168545 25.31243002337313 -6.761526624765577 1.6067184648921642 1.1729694153842525 0.7378862108358686 0.6971837778867728 0.12551672988856716 0.28035363516436457 1.4267652304695153 0.061627245130822274 0.14787789380477792 1.7317028640866098e-07 6.761526624765577 -0.4350832045483839 YFDPANGK(ub)FSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YFDPANGKFSK 11 1 P13639 P13639 EEF2 Elongation factor 2 1 486502000.0 162729000.0 138342000.0 185431000.0 True False 246871790.0834507 113653789.2290205 148780481.57270566 1.0 0.46037576505036004 0.60266295117159 27.8791867489538 -10.367178809315462 8.823397388454515 1.000001221965118 0.5315193581110459 0.9352921683451575 0.05808850048890562 1.3963047710982877e-06 1.0021086272512673e-07 0.05624409538283043 0.01874798291664108 4.29359612855055e-11 10.367178809315462 -0.4684818638540721 YFDPANGK(ub)FSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFDPANGKFSK 11 1 P13639 P13639 EEF2 Elongation factor 2 1 116819700.0 28337700.0 41397500.0 47084500.0 True False 38814913.48754794 39568421.56677418 35964110.83571655 1.0 1.0194128496374975 0.9265539351840641 25.210107736227744 -6.852131495237191 1.224729427998727 1.0103814700820062 0.922685618348517 0.9433562037717672 0.009517984847062757 0.15512542118135259 0.44668300845638387 0.006077651038164892 0.01408482242299998 1.4056218669479058e-07 6.852131495237191 -0.08769585173348915 YFDPANGK(ub)FSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YFDPANGKFSK 11 1 P13639 P13639 EEF2 Elongation factor 2 1 136217300.0 43033900.0 65053000.0 28130400.0 True False 35784594.57501515 64702546.576990545 34012336.579725936 1.0 1.8081117683576033 0.9504742748566276 25.092835298807405 -6.6596024534132745 1.974465355643277 1.5203432387474436 0.9540631679749186 0.23388519415092035 0.34410850271504684 0.48536173130145777 3.637096695708895 0.14082974836431328 0.38140565352208095 2.189765184657849e-07 6.6596024534132745 -0.566280070772525 YFDPANGK(ub)FSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFDPANGKFSK 11 1 P13639 P13639 EEF2 Elongation factor 2 1 435642000.0 162729000.0 147703000.0 125210000.0 True False 210655898.36814618 139483198.2086282 102423064.76309213 1.0 0.6621376343560281 0.4862102868066655 27.65031307104625 -13.804108070497863 0.08462891984025787 2.7264927536026597 3.144154867344686e-20 0.9998742600582281 0.0023906660218889642 11.37692265047284 0.08076601122337977 3.6679441710799554 0.42946070444834206 1.5699720814865473e-14 13.804108070497863 -2.7264927536026597 YFDSGDYNMAK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YFDSGDYNMAKAK 13 1 O43768-2;O43768;A6NMQ3;Q5T5H1;O43768-9;O43768-3;O43768-4;O43768-6;O43768-5;O43768-7;H3BQ52;P56211;H3BTD3;H3BMD8;P56211-2 O43768-2;P56211 ENSA;ARPP19 Alpha-endosulfine;cAMP-regulated phosphoprotein 19 1 7533500.0 3681800.0 2347300.0 1504400.0 True False 3564923.274315432 3284589.1310077896 1110352.508967404 1.0 0.9213632042721944 0.3114660326541316 21.76543959607586 -6.930678358523939 0.7412117080762357 1.0090454936621422 0.18407039390440397 0.9966697005821448 0.017758269385891028 0.09228743106128372 0.07596834527491889 0.016244301663705652 0.05498091992830623 1.1730638230396675e-07 6.930678358523939 -0.8249750997577383 down YFDSGDYNMAK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFDSGDYNMAKAK 13 1 O43768-2;O43768;A6NMQ3;Q5T5H1;O43768-9;O43768-3;O43768-4;O43768-6;O43768-5;O43768-7;H3BQ52;P56211;H3BTD3;H3BMD8;P56211-2 O43768-2;P56211 ENSA;ARPP19 Alpha-endosulfine;cAMP-regulated phosphoprotein 19 1 10578000.0 3243000.0 4524500.0 2810500.0 True False 4198127.429087005 4272707.597644858 2299017.838165247 1.0 1.0177651035652515 0.5476293602324572 22.00131452788414 -6.898118545360061 0.9730990556827133 1.0205683406051873 0.5001259464027715 0.9856063842380424 0.026101142718574957 0.11280300699394763 0.1853392799854935 0.020186495526079266 0.05204241496500392 1.264391171164556e-07 6.898118545360061 -0.5204423942024158 YFDSVQAK(ub)EQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFDSVQAKEQR 11 1 Q8IWV8-4;Q8IWV8 Q8IWV8-4 UBR2 E3 ubiquitin-protein ligase UBR2 1 11629100.0 3301400.0 4320300.0 4007400.0 True False 4328167.370803077 3675728.080397502 3592752.689695172 1.0 0.8492573797384095 0.8300863580117395 22.04532485877513 -13.999999999999998 0.29075943642125285 2.3045198444277624 0.824902049532455 0.9996291566742014 0.001463226260381496 16.011059769723317 0.17101445339367333 12.498960663714005 0.00721570148091634 1.0000000000000041e-14 13.999999999999998 -1.4796177948953073 YFDSVQAK(ub)EQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YFDSVQAKEQR 11 1 Q8IWV8-4;Q8IWV8 Q8IWV8-4 UBR2 E3 ubiquitin-protein ligase UBR2 1 10193200.0 3338400.0 0.0 6854800.0 True False 3232424.319347768 0.0 5059322.24040798 1.0 0.0 1.565178869038097 21.624185161980023 -6.734124428987299 1.7080542409864379 0.4009758391448557 1.564990409366185 0.5782763980770442 0.4202599301907255 0.3285912446801101 1.8798428166199235 0.19483017507224445 0.48124229660191636 1.844486882609201e-07 6.734124428987299 1.1640145702213294 YFDSVQAK(ub)EQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YFDSVQAKEQR 11 1 Q8IWV8-4;Q8IWV8 Q8IWV8-4 UBR2 E3 ubiquitin-protein ligase UBR2 1 37031300.0 8757300.0 13458000.0 14816000.0 True False 13285464.344387336 11056314.752166074 11887611.10591652 1.0 0.8322113902505032 0.8947832606948841 23.663345317003273 -10.718366549479303 9.297143528521943 1.0003286658244679 0.8634973259164327 0.8638613925002605 0.02554485914004484 0.0001744346171151896 5.284053184678787e-06 0.024792035880440603 0.008244567835883999 1.9126409528845272e-11 10.718366549479303 -0.1368313399080352 YFDSVQAK(ub)EQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFDSVQAKEQR 11 1 Q8IWV8-4;Q8IWV8 Q8IWV8-4 UBR2 E3 ubiquitin-protein ligase UBR2 1 5991400.0 3301400.0 0.0 2690000.0 True False 4522016.796980369 0.0 2054677.402289024 1.0 0.0 0.45437190849469195 22.10853492029802 -9.908885763431293 10.376652481575956 0.9999911130457844 0.22718594811154558 0.7941176765737857 0.18549655494872175 0.0 0.0 0.17960626699174864 0.0598687556639162 1.233429231072102e-10 9.908885763431293 -0.7728051649342388 YFDSVQAK(ub)EQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YFDSVQAKEQR 11 1 Q8IWV8-4;Q8IWV8 Q8IWV8-4 UBR2 E3 ubiquitin-protein ligase UBR2 1 18489600.0 3338400.0 11354000.0 3797200.0 True False 2776027.516196082 11292833.748407451 4591176.963730892 1.0 4.0679833620243535 1.6538657981395164 21.4045904374143 -6.586013531644649 2.2434888524176366 3.081566780399642 1.660411711258114 0.0 1.3307940823549664 0.6813868158368552 6.459236723156 0.496264037351906 1.4853154022605455 2.5940985345516264e-07 6.586013531644649 -1.4211550691415278 YFDSVQAK(ub)EQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFDSVQAKEQR 11 1 Q8IWV8-4;Q8IWV8 Q8IWV8-4 UBR2 E3 ubiquitin-protein ligase UBR2 1 22921300.0 8757300.0 14164000.0 0.0 True False 11336497.48219045 13375760.948843343 0.0 1.0 1.1798847898000735 0.0 23.434471639095722 -6.92359252471225 1.2522666637119706 1.095213389416544 1.6333550232565822e-18 0.9610116547696497 0.10248399463956 0.12031573030924012 0.3773071982787697 0.0674026086093056 0.1311676240863081 1.1923602111929455e-07 6.92359252471225 -1.095213389416544 down YFDTVPVAAAMCVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFDTVPVAAAMCVLK 15 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 3755980.0 833680.0 1742200.0 1180100.0 False True 1092962.553368605 1482270.5510424094 1057994.57231853 1.0 1.3561951838824886 0.9680062405227876 20.059812542159356 -6.66541920266154 1.9539415477148916 1.228247591222399 0.969612252186637 0.2588515607261658 0.15146543396719853 0.4716743513990408 3.467302399327982 0.06251046858662818 0.1679961957532145 2.1606319672919176e-07 6.66541920266154 -0.25863533903576186 YFDTVPVAAAMCVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFDTVPVAAAMCVLK 15 0 Q15393 Q15393 SF3B3 Splicing factor 3B subunit 3 0 4552980.0 833680.0 1550700.0 2168600.0 False True 1141914.025354879 1482184.9465208435 1656421.343718949 1.0 1.2979829598469261 1.4505657229353792 20.123022603682248 -11.988660889139322 0.10509028383870377 6.316735758892219e-14 1.7878934566124516 0.9998319289855798 0.0024257032078814577 5.605559607287378 0.0765362986824541 1.5024468353613434 0.25268425388571336 1.0264531004493854e-12 11.988660889139322 1.7878934566123885 YFEGVSPK(ub)SLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFEGVSPKSLK 11 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 3528800.0 0.0 2026000.0 1502800.0 True False 0.0 1723728.6972861472 1347304.6718755078 0.0 YFEITSEAPFLHYLSMFSSK ddPTM_RPMI8226_Bortezomib_8h_R1 2 YFEITSEAPFLHYLSMFSSK 20 0 P31146;H3BRY3 P31146 CORO1A Coronin-1A;Coronin 0 9520914830.0 3974239600.0 2564921230.0 2981754000.0 False True 6029212029.033173 2107190996.6854606 2392409014.9507976 1.0 0.34949691378217523 0.3968029326934182 32.489322319446856 -9.959317621570175 7.257778759889158 1.0000000175437012 0.37314992323779633 0.9957468014454088 0.01931260134916766 5.483691867052409e-09 7.678436984694556e-10 0.018699346406598927 0.0062331152831055425 1.0982023745936677e-10 9.959317621570175 -0.6268500943059048 YFEITSEAPFLHYLSMFSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 YFEITSEAPFLHYLSMFSSK 20 0 P31146;H3BRY3 P31146 CORO1A Coronin-1A;Coronin 0 8622761600.0 3974239600.0 2203407000.0 2445115000.0 False True 5144731506.174435 2080785463.4995832 2000129158.9985437 1.0 0.404449767884356 0.3887723113632061 32.2604486415393 YFFFDDGNGLK(ub)GNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFFFDDGNGLKGNR 14 1 P61009 P61009 SPCS3 Signal peptidase complex subunit 3 1 12549300.0 1339400.0 1421100.0 9788800.0 True False 1755966.3707680511 1209077.4194044129 8775948.876799947 1.0 0.6885538581673226 4.997788695099775 20.743833784817753 -6.889524061150249 1.0251737854224705 0.7658115423246029 5.365013247120442 0.9805926394644224 0.27334189078901794 0.11953097194812179 0.22410005557509535 0.20328021817475728 0.5059301966969073 1.289662104968577e-07 6.889524061150249 4.5992017047958385 up YFFFDDGNGLK(ub)GNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YFFFDDGNGLKGNR 14 1 P61009 P61009 SPCS3 Signal peptidase complex subunit 3 1 29606600.0 2033300.0 3002300.0 24571000.0 True False 1968754.0044721472 4201134.046787662 18135117.985800378 1.0 2.1339050166981375 9.211469764432392 20.90885142728821 -6.935004816878087 0.7045012126838086 0.9097092984245435 10.86880445866694 0.9974336519727034 0.18405834954248612 0.09012124376250272 0.06555160271343109 0.17299354273379755 0.623719803629339 1.1614357319696647e-07 6.935004816878087 9.959095160242397 YFFFDDGNGLK(ub)GNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YFFFDDGNGLKGNR 14 1 P61009 P61009 SPCS3 Signal peptidase complex subunit 3 1 34255300.0 2033300.0 3397000.0 28825000.0 True False 1690779.0404629442 3378699.6867482956 34852174.22825844 1.0 1.9983094218054596 20.613086272181214 20.689256702722485 -6.917985770749697 0.8395227730899919 0.5587167672660431 23.480160828341415 0.9936030954423395 0.7213939907146901 0.09937134739420402 0.11185964312234357 0.6150161940627507 1.8082596124574828 1.2078534086395902e-07 6.917985770749697 22.92144406107537 up YFGGMVWYFVNNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YFGGMVWYFVNNK 13 0 G5E9W7;G5E9V5;P82650;H7C5L9 G5E9W7 MRPS22 28S ribosomal protein S22, mitochondrial 0 21169700.0 5315600.0 8020200.0 7833900.0 False True 8064153.822413902 6588932.647891384 6285526.231279655 1.0 0.8170643557886735 0.7794402698283555 22.943091727596176 -13.999999999999998 0.2223038419007527 2.115194092652673 0.7597540147746918 0.9995003024682416 0.002153504736961494 13.063266175193073 0.14934640037212793 6.403106448610398 0.02051013725590789 1.0000000000000041e-14 13.999999999999998 -1.3554400778779812 YFGGMVWYFVNNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFGGMVWYFVNNK 13 0 G5E9W7;G5E9V5;P82650;H7C5L9 G5E9W7 MRPS22 28S ribosomal protein S22, mitochondrial 0 20073200.0 5315600.0 7469600.0 7288000.0 False True 6881148.986140878 7053910.193693897 5961658.7811949095 1.0 1.0251064477605372 0.8663754836876971 22.714218049688625 -6.866433578461737 1.1527255722930487 1.0139361103514979 0.8576856951675338 0.9609960319222501 0.013758820363232302 0.1403241130083805 0.3507208274351166 0.009281512848210414 0.021849308316408265 1.36008616064759e-07 6.866433578461737 -0.1562504151839641 YFHPPAHLQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFHPPAHLQAK 11 0 Q9NR56;C9JP00;A0A0A0MQX8;Q9NR56-6;Q9NR56-7;Q9NR56-4;H7C4T5;Q9NR56-3;Q9NR56-2;Q9NR56-5;Q5VZF2-3;Q5VZF2-2;O95205;Q5VZF2;Q86VM6;H7C4Y1;C9JCX1 Q9NR56 MBNL1;MBNL2;MBLL Muscleblind-like protein 1;Muscleblind-like protein 2 0 5639750.0 645450.0 2448500.0 2545800.0 False True 846191.2005466907 2083193.3441782445 2282385.0370379733 1.0 2.4618470894431135 2.697245061829306 19.690624157775062 -10.391493538475302 0.3869695530299073 5.025215643038025e-13 2.7244491771149932 0.9991766524686013 0.021542936009220907 1.8235208991113143 0.18147221062252408 1.916301568912042 0.06216803636275427 4.0598170348785647e-11 10.391493538475302 2.7244491771144905 YFHPPAHLQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YFHPPAHLQAK 11 0 Q9NR56;C9JP00;A0A0A0MQX8;Q9NR56-6;Q9NR56-7;Q9NR56-4;H7C4T5;Q9NR56-3;Q9NR56-2;Q9NR56-5;Q5VZF2-3;Q5VZF2-2;O95205;Q5VZF2;Q86VM6;H7C4Y1;C9JCX1 Q9NR56 MBNL1;MBNL2;MBLL Muscleblind-like protein 1;Muscleblind-like protein 2 0 6460150.0 1603800.0 992950.0 3863400.0 False True 1552888.2468757364 1389440.1131658447 2851459.640484361 1.0 0.8947457204092221 1.8362297777842205 20.566522579680864 -6.87914325069342 1.084608939404391 0.9354819821639571 1.9018543906254095 0.9729858952686936 0.069229727633398 0.1283897259784013 0.2769185608396438 0.04920780975463747 0.11873822420476061 1.3208598807727272e-07 6.87914325069342 0.9663724084614524 YFHPPAHLQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YFHPPAHLQAK 11 0 Q9NR56;C9JP00;A0A0A0MQX8;Q9NR56-6;Q9NR56-7;Q9NR56-4;H7C4T5;Q9NR56-3;Q9NR56-2;Q9NR56-5;Q5VZF2-3;Q5VZF2-2;O95205;Q5VZF2;Q86VM6;H7C4Y1;C9JCX1 Q9NR56 MBNL1;MBNL2;MBLL Muscleblind-like protein 1;Muscleblind-like protein 2 0 2775700.0 1603800.0 855380.0 316520.0 False True 1333630.760386797 850771.8981603642 382702.86857687304 1.0 0.6379366189136282 0.28696313848210625 20.34692785511514 -7.475222581202845 0.29375148207925783 1.0914580501939153 2.520913558328572e-12 0.9997510522615305 0.00459311812665612 0.12257987739518052 0.02908017039962876 0.021851598488731885 0.06316428481368062 3.3479380928215186e-08 7.475222581202845 -1.0914580501913944 down YFHVVIAGPQDSPFEGGTFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFHVVIAGPQDSPFEGGTFK 20 0 P61088;F8VSD4;F8VV71;F8VZ29 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 0 45255000.0 14027000.0 21964000.0 9264000.0 False True 18389532.837661248 18687056.815001447 8305450.146562878 1.0 1.0161789850762755 0.4516400835128095 24.13238149462207 -6.900301328923327 0.9593487747813447 1.0232777961516843 0.39201570046402257 0.9867159767844319 0.030242791046193634 0.11118423592344762 0.17616632052355477 0.023629671358040734 0.06157466342976467 1.2580522276261652e-07 6.900301328923327 -0.6312620956876618 down YFHVVIAGPQDSPFEGGTFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YFHVVIAGPQDSPFEGGTFK 20 0 P61088;F8VSD4;F8VV71;F8VZ29 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 0 185227000.0 73980000.0 53947000.0 57300000.0 False True 71631545.3946047 75488318.42988843 42291411.03684674 1.0 1.0538418236551717 0.59040204708514 26.09409173161535 -6.877955609446536 1.0910779719549097 1.0325523359622848 0.558811657078734 0.9720012918331425 0.03462816069659277 0.12945926137857589 0.2833268997787309 0.024490438395346054 0.058931385446035475 1.3244769070695965e-07 6.877955609446536 -0.47374067888355076 YFHVVIAGPQDSPFEGGTFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YFHVVIAGPQDSPFEGGTFK 20 0 P61088;F8VSD4;F8VV71;F8VZ29 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 0 853238000.0 268911000.0 268765000.0 315562000.0 False True 407957647.0274556 220801785.8794703 253191032.38426197 1.0 0.5412370315603137 0.6206306812217254 28.603844142680266 -10.775290611280141 7.077056600389841 1.0107646896371845 0.5809338563910196 0.973786123988511 0.03241232174795819 0.0054779880775191695 0.0001739358067600003 0.031228467181195395 0.010461031861813212 1.677681010100268e-11 10.775290611280141 -0.4298308332461649 YFHVVIAGPQDSPFEGGTFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFHVVIAGPQDSPFEGGTFK 20 0 P61088;F8VSD4;F8VV71;F8VZ29 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 0 65244000.0 14027000.0 24092000.0 27125000.0 False True 19213160.96542186 23027535.77840991 20718633.656910684 1.0 1.1985292695904033 1.0783563253437705 24.19559155614496 -10.272786050068907 4.170383694025532 0.9998716165212772 1.1384427974727143 0.6389322232866403 0.0490603990674991 5.861645396103132e-05 1.0221352663736443e-05 0.0475465058744163 0.015834175709628213 5.3359770121097174e-11 10.272786050068907 0.13857118095143706 YFHVVIAGPQDSPFEGGTFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YFHVVIAGPQDSPFEGGTFK 20 0 P61088;F8VSD4;F8VV71;F8VZ29 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 0 139068400.0 73980000.0 44758400.0 20330000.0 False True 61517647.869694024 44517277.61535317 24580909.004700582 1.0 0.7236505158592726 0.39957491640069825 25.874497007049627 -6.969025038415463 0.2804998097837827 1.0709671379330714 0.04237631183932143 0.9999737458154266 0.001257287903519997 0.07662036563768775 0.010157762764300618 0.005968878055020238 0.02972733986460507 1.0739274953262464e-07 6.969025038415463 -1.02859082609375 down YFHVVIAGPQDSPFEGGTFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFHVVIAGPQDSPFEGGTFK 20 0 P61088;F8VSD4;F8VV71;F8VZ29 P61088 UBE2N Ubiquitin-conjugating enzyme E2 N 0 745785000.0 268911000.0 255886000.0 220988000.0 False True 348110590.52828056 241645719.1581282 180770451.52836192 1.0 0.6941636529684864 0.5192902958052237 28.374970464772716 -11.175498133465076 0.08952161916302696 2.0364788894226784 1.1396825650573833e-16 0.9999217915020372 0.0017568669067438074 3.7084451322310508 0.05667895005976653 1.1216906998638565 0.3418530071809772 6.675777701109252e-12 11.175498133465076 -2.0364788894226784 YFIHYSGWNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFIHYSGWNK 10 0 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;H0YLJ3;H0YNE0 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 0 9113950.0 3842600.0 4789600.0 481750.0 False True 5037685.811791331 4075010.3497145735 431903.13127230835 1.0 0.8089052199675701 0.08573443192137654 22.264329716822058 -7.150731788336242 0.7277709839683628 0.9974417250573746 1.751436776506295e-21 0.9963146150990736 0.023903725120696228 0.08293036370385382 0.07628341152966601 0.021852440387015806 0.055824634307343406 7.067538967087225e-08 7.150731788336242 -0.9974417250573746 down YFIHYSGWNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YFIHYSGWNK 10 0 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;H0YLJ3;H0YNE0 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 0 5593600.0 2119400.0 1062500.0 2411700.0 False True 2052120.8071009063 1486761.7908643025 1780003.4205508416 1.0 0.7245001296803263 0.8673969945587691 20.96868423334671 -10.194375162734646 5.192706172023146 1.0000133772399356 0.7959485621194515 0.7310939651152579 0.05833740079960557 9.03520296324885e-06 1.4017851755623564e-06 0.05648864676597457 0.01882831514644333 6.391824429313813e-11 10.194375162734646 -0.20406481512048402 YFIHYSGWNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFIHYSGWNK 10 0 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;H0YLJ3;H0YNE0 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 0 10817600.0 3842600.0 2583000.0 4392000.0 False True 5263313.062360441 2468874.5191612476 3354700.056079328 1.0 0.46907232952129013 0.6373742196849 22.32753977834495 -10.3946420700304 5.186226977133453 1.000324016341059 0.5532232746030757 0.9038089211241639 0.06870895894120012 0.0002575976080335498 3.0067915494674768e-05 0.06657440270884848 0.022175721142866416 4.030490761025282e-11 10.3946420700304 -0.4471007417379832 YFIHYSGWNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YFIHYSGWNK 10 0 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;H0YLJ3;H0YNE0 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 0 4592100.0 2119400.0 1278800.0 1193900.0 False True 1762375.005339678 1271910.8505780732 1443538.9700301054 1.0 0.721702728831499 0.8190872916697315 20.749089508780987 -10.88595321783151 10.546434514074935 1.0143944276833807 0.7703950102506152 0.8811187627813168 0.039757081296279057 0.012744899529741805 0.00013782025076043103 0.03646027294203026 0.012831542812858598 1.3003096397447242e-11 10.88595321783151 -0.24399941743276554 YFIHYSGWNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFIHYSGWNK 10 0 Q9UBU8-2;Q9UBU8;B3KTM8;H0YMJ0;H0YLJ3;H0YNE0 Q9UBU8-2 MORF4L1 Mortality factor 4-like protein 1 0 15343800.0 2001900.0 6697200.0 6644700.0 False True 2591499.0133485226 6324494.932688055 5435432.780379504 1.0 2.440477461157147 2.0974087786189366 21.305355413775143 -10.5059607362184 5.497860865721666 0.9975605999923666 2.2689431198880445 0.9480290394797183 0.1400572031579229 0.004191802697779246 0.0003766763078243281 0.1357400340186726 0.04520326794558408 3.119171570028369e-11 10.5059607362184 1.271382519895678 YFINHVTQTTSWIHPVMSVLNLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFINHVTQTTSWIHPVMSVLNLSR 24 0 E7EPP7;Q6ZWJ1 E7EPP7 STXBP4 Syntaxin-binding protein 4 0 16718300.0 6606800.0 6013700.0 4097800.0 False True 8552632.839497985 5679032.30853285 3352042.4469786645 1.0 0.6640098335925049 0.3919310591117834 23.027937176431543 -7.510571150700313 0.20327133076375303 1.1950154702044513 6.466637345715764e-12 0.9999450349035468 0.001843812334478225 0.1292061186884987 0.01928538237107269 0.03249362069643926 0.06665857410161011 3.0862339848774845e-08 7.510571150700313 -1.1950154701979847 down YFK(ub)DQMSPEPIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFKDQMSPEPIR 12 1 Q9UN19;J3KNB3;Q9UN19-2 Q9UN19 DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 1 4754600.0 1563300.0 1383400.0 1807900.0 True False 2049501.4390187368 1177002.1124509636 1620835.8506013653 1.0 0.574287038810029 0.7908439680712747 20.966841572258303 -10.495976155203353 7.331441201685849 1.0000640368535432 0.6825655034406612 0.7412581523633066 0.08840899615900727 9.2556647228543e-05 6.363117976273875e-06 0.08561881051857186 0.02853388081489587 3.191713090254606e-11 10.495976155203353 -0.3174985334128819 YFK(ub)DQMSPEPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YFKDQMSPEPIR 12 1 Q9UN19;J3KNB3;Q9UN19-2 Q9UN19 DAPP1 Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide 1 5207700.0 1080700.0 2335200.0 1791800.0 True False 898649.9331275781 2322619.8140990906 2166457.0956528517 1.0 2.5845657229569468 2.4107909162279855 19.777399701303846 -10.198188156625504 4.174193478776236 0.9993269429444896 2.497678319712704 0.9900038059579355 0.07094326818212607 11080605.294858605 13713679.895417165 86393.54771365746 0.025962576853906013 6.33595148814595e-11 10.198188156625504 1.4983513767682144 YFLHTGHLTIAGCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFLHTGHLTIAGCK 14 0 B4DKY1;P49589-2;P49589;P49589-3 B4DKY1 CARS Cysteine--tRNA ligase, cytoplasmic 0 16776700.0 5591100.0 5055100.0 6130500.0 False True 7329986.244289422 4300898.784625463 5496174.667908436 1.0 0.5867540048900047 0.7498205978476896 22.80537906027343 -10.09608507820236 5.117936721490904 1.000007844815358 0.6682873013681189 0.8465641212964166 0.06657165780927697 5.9590397149582965e-06 1.0524222855470517e-06 0.06445925474900328 0.021485910168364996 8.015210301968885e-11 10.09608507820236 -0.3317205434472391 YFLHTGHLTIAGCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFLHTGHLTIAGCK 14 0 B4DKY1;P49589-2;P49589;P49589-3 B4DKY1 CARS Cysteine--tRNA ligase, cytoplasmic 0 31241900.0 5591100.0 4245800.0 21405000.0 False True 7658280.763796255 4058206.517016962 16349579.84981283 1.0 0.529910908490287 2.1348890637574702 22.868589121796322 -6.828292326625577 1.3355015475407102 0.7485036928493507 2.1765980539001633 0.9024228011907651 0.2104477376388156 0.1829255971327741 0.6386747324754479 0.12374618147506129 0.2848046092503559 1.484935785251248e-07 6.828292326625577 1.4280943610508126 up YFLNLVLVDEEDRR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YFLNLVLVDEEDRR 14 1 O75436 O75436 VPS26A Vacuolar protein sorting-associated protein 26A 0 24119500.0 6052700.0 10988000.0 7078800.0 False True 9182388.411642078 9027105.55036416 5679672.077251747 1.0 0.983089055448685 0.6185397330884695 23.13043802813313 -6.916587460395336 0.8496457685895555 1.00907467290573 0.5641307610221568 0.9931793976805746 0.014532956755979438 0.10022164682909572 0.11632429102547438 0.012300401415410465 0.035725085075428396 1.2117486361993193e-07 6.916587460395336 -0.4449439118835733 YFLQGMGYIPSASMTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFLQGMGYIPSASMTR 16 0 F8WBF9;Q9UGV2-3;Q9UGV2-2;Q9UGV2 F8WBF9 NDRG3 Protein NDRG3 0 3410590.0 620690.0 1278800.0 1511100.0 False True 850175.8665165525 1222298.3875739058 1154209.3020813917 1.0 1.437700640200551 1.357612404137703 19.6974017809897 -10.013831627367194 4.8758730204332394 0.9999938187501528 1.3976565221762578 0.9704765200249783 0.03269588548354195 2.1969696708240836e-06 4.4438196234058717e-07 0.03165814732287453 0.010552551660430646 9.686533229223594e-11 10.013831627367194 0.397662703426105 YFLVGAGAIGCELLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFLVGAGAIGCELLK 15 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 24079400.0 9588200.0 10859000.0 3632200.0 False True 12570223.052260894 9238879.528050462 3256374.78652264 1.0 0.7349813515352654 0.25905465423996155 23.58350691409212 -7.056958292947816 0.4283950391780228 1.0202804365951952 1.3680346710310982e-16 0.9997930003282078 0.004410440043363008 0.07367452226976529 0.020692666720074616 0.006462318620000657 0.03692346913837324 8.770850471168336e-08 7.056958292947816 -1.020280436595195 down YFLVGAGAIGCELLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YFLVGAGAIGCELLK 15 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 32622900.0 23556000.0 6240300.0 2826600.0 False True 22808227.673902497 8732084.332734596 2086228.6638176441 1.0 0.38284799930886226 0.09146824968801662 24.44305100979132 -8.897645605222554 0.3356321801304799 1.1960405926064612 4.165038024664279e-15 0.9981250308094878 0.016401138904068656 0.39953504392880695 0.1157289069788636 0.18723452874651353 0.08506534709581584 1.2657688240563889e-09 8.897645605222554 -1.196040592606457 YFLVGAGAIGCELLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFLVGAGAIGCELLK 15 0 P22314-2;P22314 P22314-2 UBA1 Ubiquitin-like modifier-activating enzyme 1 0 48449100.0 9588200.0 9890900.0 28970000.0 False True 13133216.651362218 9453887.333167631 22127882.655878466 1.0 0.7198455324489789 1.6848791307789242 23.64671697561501 -6.829047218135691 1.332316923275014 0.8502066202969488 1.710317217147292 0.9039255245202403 0.12564428319213022 0.18199141680284675 0.6321564561337665 0.07405484318622614 0.1704148765941826 1.482356908944697e-07 6.829047218135691 0.8601105968503432 YFLWVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFLWVVK 7 0 P62993;P62993-2 P62993 GRB2 Growth factor receptor-bound protein 2 0 21551900.0 6501500.0 8000100.0 7050300.0 False True 8523529.460615557 6806516.264145556 6320802.587253052 1.0 0.7985560788633679 0.7415710377325982 23.02301952101191 -13.999999999997476 0.17711744697700665 2.036196916794382 0.6949317865092081 0.9995018968181261 0.0024742255085745206 12.168840430152224 0.1333840593544472 4.336705586358285 0.04361292364571342 1.0000000000058122e-14 13.999999999997476 -1.3412651302851741 YFLWVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YFLWVVK 7 0 P62993;P62993-2 P62993 GRB2 Growth factor receptor-bound protein 2 0 21297400.0 9304500.0 5668900.0 6324000.0 False True 9009133.740525795 7932521.332922965 4667554.68406665 1.0 0.8804976772894487 0.5180913968532385 23.1029569618969 -6.951207280455595 0.5454297588648823 1.0051531821349076 0.37654351676803643 0.9992926443718484 0.005449542025009642 0.08300457243403361 0.033984019031168294 0.005950159791907405 0.030039655567211134 1.1189037246430913e-07 6.951207280455595 -0.6286096653668711 YFLWVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YFLWVVK 7 0 P62993;P62993-2 P62993 GRB2 Growth factor receptor-bound protein 2 0 27008800.0 8630900.0 6938900.0 11439000.0 False True 13093706.303309528 5700599.081126844 9178076.636108201 1.0 0.4353694018389565 0.7009532995091219 23.642370188428483 -10.432907390301366 6.115102840147124 1.0001470590921777 0.5681613506740466 0.7790131163966619 0.10842417219857477 0.00021745514312530807 2.0165820282040993e-05 0.10501655041607569 0.03499375110428374 3.690562883744655e-11 10.432907390301366 -0.4319857084181311 YFLWVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFLWVVK 7 0 P62993;P62993-2 P62993 GRB2 Growth factor receptor-bound protein 2 0 27715800.0 6501500.0 8417300.0 12797000.0 False True 8905280.246431168 8045395.853711176 9774612.162487973 1.0 0.9034410631754576 1.0976198268892428 23.086229582534802 -6.771465423220636 1.5685908824622055 0.9447219263193667 1.0987800990065988 0.7362571703668446 0.040711639717369436 0.26404872970150123 1.282337440918904 0.020454346937811365 0.04862971208468517 1.6925229909434154e-07 6.771465423220636 0.1540581726872321 YFLWVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YFLWVVK 7 0 P62993;P62993-2 P62993 GRB2 Growth factor receptor-bound protein 2 0 19070000.0 9304500.0 4820300.0 4945200.0 False True 7737104.009239891 4794332.087145368 5979218.455978614 1.0 0.619654599630537 0.7727979937762302 22.883362237331177 -10.098714738315955 5.109936095377054 1.0000075342507835 0.6962262980965612 0.8399019501500398 0.06252052885815262 5.366466885668727e-06 9.465003385739217e-07 0.0605367427569427 0.02017841392163956 7.966824709530132e-11 10.098714738315955 -0.30378123615422226 YFLWVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFLWVVK 7 0 P62993;P62993-2 P62993 GRB2 Growth factor receptor-bound protein 2 0 47582900.0 8630900.0 24012000.0 14940000.0 False True 11172870.190473942 22675711.091755625 12221073.297345227 1.0 2.0295332090306637 1.0938168160017636 23.413496510520933 -6.623417065988638 2.1048526012684885 1.6814996190322933 1.0974988458667598 0.09422643786224849 0.4423548626317247 0.5762642590474986 4.856376410609765 0.17242993147419566 0.49014815228001907 2.380032754849582e-07 6.623417065988638 -0.5840007731655334 YFNDK(ub)TIDEELER ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFNDKTIDEELER 13 1 Q9Y320-2;Q9Y320 Q9Y320-2 TMX2 Thioredoxin-related transmembrane protein 2 1 19772400.0 3399100.0 3447300.0 12926000.0 True False 4456253.016931225 2932976.2774701514 11588541.5149473 1.0 0.6581709490745951 2.600512464377009 22.08739971760109 -6.861452446066988 1.178278211563551 0.8137561638464758 2.6972564433864368 0.9553875873712251 0.17882412407109827 0.1453184326653512 0.3825289774057892 0.11829371460678922 0.2766179898058877 1.375775445280775e-07 6.861452446066988 1.8835002795399611 up YFNDK(ub)TIDEELER ddPTM_RPMI8226_Bortezomib_2h_R1 1 YFNDKTIDEELER 13 1 Q9Y320-2;Q9Y320 Q9Y320-2 TMX2 Thioredoxin-related transmembrane protein 2 1 35772400.0 3635800.0 5422600.0 26714000.0 True False 3520383.5191363026 7587872.458485438 19716801.997178443 1.0 2.1554107435280403 5.600753977514302 21.74730117745264 -6.951586479241753 0.5411465634566308 0.9496547002746678 6.965928975789423 0.9993199749107795 0.05096188865219028 0.08285488310134413 0.0333737865796803 0.055964445247266056 0.28537589532788565 1.1179271942578979e-07 6.951586479241753 6.016274275514755 YFNDK(ub)TIDEELER ddPTM_RPMI8226_Bortezomib_8h_R1 1 YFNDKTIDEELER 13 1 Q9Y320-2;Q9Y320 Q9Y320-2 TMX2 Thioredoxin-related transmembrane protein 2 1 110883900.0 4158200.0 48797800.0 57927900.0 True False 6308293.405139863 40089451.33104837 46478425.17429947 1.0 6.355039113809187 7.367828696177931 22.588818332226246 -9.449632109067965 0.5098716984702567 5.347722660155324e-21 7.350752593239294 0.9982889664186366 0.11556746647974296 0.782408442599516 0.2183688998580088 1.7714718449873137 0.20061767722752236 3.55114079057246e-10 9.449632109067965 7.350752593239294 YFNDK(ub)TIDEELER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFNDKTIDEELER 13 1 Q9Y320-2;Q9Y320 Q9Y320-2 TMX2 Thioredoxin-related transmembrane protein 2 1 19297900.0 3399100.0 2821800.0 13077000.0 True False 4655839.127223596 2697123.545555248 9988481.92926897 1.0 0.5792991277951686 2.145366636674445 22.150609779123982 -6.835193992210498 1.304473576997801 0.7758791737715928 2.1921817047167313 0.9158821764605545 0.19193279768112043 0.17448561317212397 0.5788110069947445 0.11545434952002778 0.2657466948490956 1.4615241897830826e-07 6.835193992210498 1.4163025309451385 up YFNDK(ub)TIDEELER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YFNDKTIDEELER 13 1 Q9Y320-2;Q9Y320 Q9Y320-2 TMX2 Thioredoxin-related transmembrane protein 2 1 23024800.0 3635800.0 4890000.0 14499000.0 True False 3023328.7932499787 4863656.599410999 17530673.8641984 1.0 1.608709118991563 5.798467537946313 21.527706452886918 -6.933003856122113 0.7217085660856998 0.9428425330785233 6.728324142566488 0.9970963932257851 0.11494075128252308 0.09110784615992637 0.0702570669481291 0.10665437136615363 0.3730370877793822 1.1667992569468498e-07 6.933003856122113 5.785481609487965 up YFNDK(ub)TIDEELER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFNDKTIDEELER 13 1 Q9Y320-2;Q9Y320 Q9Y320-2 TMX2 Thioredoxin-related transmembrane protein 2 1 99478100.0 4158200.0 26063000.0 69256900.0 True False 5382871.870376057 24612571.138781708 56652854.83580375 1.0 4.572386586839235 10.524652304578426 22.359944654318696 -6.963452607954454 0.383687394663479 0.6077148497023644 14.701047800692193 0.999877603144604 0.043464158454865294 0.07849009114233738 0.016736437791696628 0.07719444498207266 0.502091519148625 1.0877958360239625e-07 6.963452607954454 14.093332950989828 YFNK(ub)NEDVCSCSTDTSEVPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFNKNEDVCSCSTDTSEVPR 20 1 P49790;P49790-3;P49790-2 P49790;P49790-2 NUP153 Nuclear pore complex protein Nup153 1 8312200.0 0.0 4512200.0 3800000.0 True False 0.0 4261092.103457422 3108438.991292629 0.0 YFQFQEEGK(ub)EGENR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YFQFQEEGKEGENR 14 1 O15144 O15144 ARPC2 Actin-related protein 2/3 complex subunit 2 1 5251200.0 1711100.0 1378000.0 2162100.0 True False 1422855.4645827694 1370576.4404884174 2614185.113579102 1.0 0.9632576706519645 1.8372808613738372 20.440357687885548 -6.897088064994354 0.9795115973249824 0.9607011705620667 1.9237811335070307 0.985060441520589 0.04933554118513114 0.11358004536654502 0.18976288115005022 0.03797377436897857 0.09743215256669999 1.2673948410941513e-07 6.897088064994354 0.963079962944964 YFQHLLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFQHLLGK 8 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 31002600.0 9630500.0 8631100.0 12741000.0 False True 12625678.761894654 7343373.523764291 11422683.540301995 1.0 0.5816220784839863 0.9047183724313185 23.589857614063813 -9.800801668706466 6.104234050347347 1.0000000122873456 0.7431702254573532 0.4572566525674777 0.13190350966027486 2.2136319070950027e-08 4.364746388431353e-09 0.12771503166707399 0.04257167468488968 1.581970320123799e-10 9.800801668706466 -0.25682978682999236 YFQHLLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YFQHLLGK 8 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 16984100.0 6625200.0 2736700.0 7622200.0 False True 6414886.652451129 3829478.5817019693 5625717.158901455 1.0 0.5969674585347078 0.8769784196813311 22.612992343229724 -10.118902200138061 5.517080110517262 1.0000036217067712 0.7369729391079572 0.5405453789442572 0.1143139961994713 5.092563424822576e-06 8.131613514310258e-07 0.11068557462849532 0.036894683626549074 7.604975159986457e-11 10.118902200138061 -0.2630306825988139 YFQHLLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YFQHLLGK 8 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 17967800.0 6478700.0 8998000.0 2491100.0 False True 9828661.55641375 7392236.598305125 1998732.9931120812 1.0 0.7521101989193308 0.20335759672259715 23.22856353651103 -7.102296256788185 0.510635324643285 1.0093607144564312 2.7799472436375878e-21 0.9994174757439074 0.008033978605184972 0.07670746126777338 0.031368020017844125 0.009206214325194417 0.04254672220806198 7.901394453870118e-08 7.102296256788185 -1.0093607144564312 down YFQHLLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFQHLLGK 8 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 35947500.0 9630500.0 11624000.0 14693000.0 False True 13191156.104476715 11110413.244572314 11222816.011833688 1.0 0.8422622821362675 0.8507833523420266 23.653067675586705 -9.848989888433415 5.9626983640602385 1.0000000210337963 0.8465228172395958 0.9976934640040789 0.003478712345015286 9.73343344000903e-10 1.8518432706593363e-10 0.0033682491960799706 0.0011227495814542824 1.415826743902816e-10 9.848989888433415 -0.1534772037942005 YFQHLLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YFQHLLGK 8 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 14738000.0 6625200.0 5620500.0 2492300.0 False True 5509147.346124579 5590221.250918098 3013428.406906797 1.0 1.0147162346003598 0.5469863515316212 22.393397618664 -6.899636534881694 0.9635769256743242 1.0196409015453596 0.4982534548842715 0.9863842104594416 0.02533320740369106 0.11167281926003056 0.1789387207528502 0.01973195212732323 0.05124540295821427 1.2599794592684902e-07 6.899636534881694 -0.5213874466610882 YFQHLLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFQHLLGK 8 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2;J3KTF1;J3QL06;Q9BST8;J3QQH7;J3QLE9 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 17662500.0 6478700.0 4925000.0 6258800.0 False True 8386804.864269488 4650919.420577064 5119762.620711138 1.0 0.5545520011311449 0.6104544821977425 22.999689858603478 -10.127502222037716 5.183047031596069 1.0000125445789612 0.5825032416645342 0.986731668637414 0.022822092329728882 3.3083453640270805e-06 5.569338561802804e-07 0.022098059533794363 0.007365798626323546 7.455860572784648e-11 10.127502222037716 -0.417509302914427 YFQIGTIVDNPADFYHSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFQIGTIVDNPADFYHSR 18 0 Q5QJE6 Q5QJE6 DNTTIP2 Deoxynucleotidyltransferase terminal-interacting protein 2 0 4201500.0 1128200.0 1502300.0 1571000.0 False True 1479081.1255043424 1278162.6959195344 1408447.9900961013 1.0 0.8641599665357788 0.9522452594450109 20.49626975371046 -10.618202446780174 5.172722379261679 1.0009725178278495 0.9082026129903945 0.5915166187507259 0.03596067024520376 0.0004075370624209012 3.0080182013088348e-05 0.035183113798306014 0.01160625641484407 2.4087823108017178e-11 10.618202446780174 -0.09276990483745495 YFQLQTDHTPVHLALLDEISTCHQLLHPQVLQLLVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YFQLQTDHTPVHLALLDEISTCHQLLHPQVLQLLVK 36 0 X6RLT1;H0UI80;Q8IXH7-4;Q8IXH7 X6RLT1 NELFCD;TH1L Negative elongation factor C/D 0 169058000.0 31498000.0 30233000.0 107327000.0 False True 47784768.8122494 24837684.938492827 86113771.40690479 1.0 0.5197824653307898 1.8021175689947029 25.5100475029047 -6.805299023395258 1.4344080410357698 0.7367968434471196 1.8221746305839626 0.8471381298953252 0.20681849500223562 0.21328627931154284 0.8657796831720731 0.1134064586493003 0.26291019253852627 1.5656726912770305e-07 6.805299023395258 1.085377787136843 YFQLQTDHTPVHLALLDEISTCHQLLHPQVLQLLVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFQLQTDHTPVHLALLDEISTCHQLLHPQVLQLLVK 36 0 X6RLT1;H0UI80;Q8IXH7-4;Q8IXH7 X6RLT1 NELFCD;TH1L Negative elongation factor C/D 0 68059000.0 31498000.0 18094000.0 18467000.0 False True 40774781.91840342 17087052.994095687 15106195.487421298 1.0 0.41905933496565345 0.3704788787749033 25.28117382499715 -13.999999999999998 0.35153038694282246 8.212072198919564 0.3639024207453688 0.9997576141413772 0.004452612187048013 20.813029241230872 0.19096875989171236 112.16914175876268 0.014419259584298549 1.0000000000000041e-14 13.999999999999998 -7.848169778174196 YFQTYFLTPSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YFQTYFLTPSVK 12 0 A0A140T8Y2;P36915-2;P36915 A0A140T8Y2 GNL1 Guanine nucleotide-binding protein-like 1 0 10486200.0 4153000.0 2337600.0 3995600.0 False True 4021165.2882372662 3271015.8704229593 2949032.494569369 1.0 0.8134497430362666 0.7333775866403439 21.939182208028786 -13.999999998074768 0.11540443099873993 1.893045996861276 0.5972896414568356 0.9997157543413487 0.001883274470485602 11.983662760703334 0.10392768631250023 2.470734444563472 0.12076654379245094 1.0000000044330094e-14 13.999999998074768 -1.2957563554044405 YFQTYFLTPSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFQTYFLTPSVK 12 0 A0A140T8Y2;P36915-2;P36915 A0A140T8Y2 GNL1 Guanine nucleotide-binding protein-like 1 0 12259500.0 3724800.0 3659700.0 4875000.0 False True 5101959.218935142 3498002.352990478 3723625.403776577 1.0 0.6856194263584422 0.7298422515720844 22.282619936536772 -10.227099153393207 4.7888590839004666 1.0000581392937775 0.7077308389645136 0.9831191448102359 0.01805389279553111 1.120883728923791e-05 1.8090204607716784e-06 0.017484076591455157 0.005826868843909066 5.927899697698423e-11 10.227099153393207 -0.2923273003292639 YFQTYFLTPSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YFQTYFLTPSVK 12 0 A0A140T8Y2;P36915-2;P36915 A0A140T8Y2 GNL1 Guanine nucleotide-binding protein-like 1 0 9016800.0 4153000.0 2711100.0 2152700.0 False True 3453403.5090948767 2696494.766188781 2602819.617039789 1.0 0.780822385535689 0.7536969283157929 21.719587483463062 -13.999999999866182 0.2946750538551967 2.9393073389825046 0.7466472530565792 0.9996379258324083 0.0020982805638262436 16.250071080256774 0.17225760498635226 19.155811929525267 0.010033193939169656 1.000000000308128e-14 13.999999999866182 -2.1926600859259255 YFSLIPTGFADEDINK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFSLIPTGFADEDINKR 17 1 A0A5K1VW28;H0YH69;Q9HBU6 A0A5K1VW28 ETNK1 Ethanolamine kinase 1 1 10598200.0 1238300.0 2005000.0 7354900.0 True False 1623423.2917142576 1705861.8154287857 6593885.501182566 1.0 1.050780670780864 4.061716703731494 20.63060778685366 -6.910560663114653 0.8918981997082374 0.9084201956694543 4.455545470347062 0.9911316535423013 0.1348059519398847 0.10404870015867981 0.13676119314386426 0.11067426379015018 0.3067148593534148 1.2286815499155343e-07 6.910560663114653 3.547125274677607 up YFSLIPTGFADEDINK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 YFSLIPTGFADEDINKR 17 1 A0A5K1VW28;H0YH69;Q9HBU6 A0A5K1VW28 ETNK1 Ethanolamine kinase 1 1 72361700.0 5175700.0 33070000.0 34116000.0 True False 7851915.294353912 27168400.12291071 27372957.646425996 1.0 3.460098473355505 3.486150400286298 22.904613178568056 -10.534014120456309 0.8465261534703941 1.2657590260482538e-15 3.4801797630783664 0.9999843948142091 0.004605660416816397 2.0276053566233614 0.4608949964840828 4.446848410224625 0.0036563218394186714 2.924057304807938e-11 10.534014120456309 3.480179763078365 YFSLIPTGFADEDINK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFSLIPTGFADEDINKR 17 1 A0A5K1VW28;H0YH69;Q9HBU6 A0A5K1VW28 ETNK1 Ethanolamine kinase 1 1 20295300.0 1238300.0 2684000.0 16373000.0 True False 1696132.9737992338 2565412.0051989085 12506034.612519773 1.0 1.5125064159636865 7.373263067050116 20.69381784837655 -6.92410101910248 0.7937200639524119 0.8887820157005117 8.413653116404205 0.9952463548460937 0.19933636764981078 0.09581833345117888 0.09354825172993604 0.17559108844571247 0.5484979324808296 1.1909649513090695e-07 6.92410101910248 7.5248711007036935 up YFSLIPTGFADEDINK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFSLIPTGFADEDINKR 17 1 A0A5K1VW28;H0YH69;Q9HBU6 A0A5K1VW28 ETNK1 Ethanolamine kinase 1 1 70330700.0 5175700.0 24132000.0 41023000.0 True False 6700045.678299601 22789032.98626712 33557234.93152565 1.0 3.40132501783939 5.008508380802877 22.675739500660505 -8.210739907317299 0.2565779277847306 9.50151483405769e-15 6.3093487815629095 0.9994079538922322 0.040078130648851705 0.09235352389701877 0.057898795517853076 0.49368265838031716 0.558759885181542 6.155454035826653e-09 8.210739907317299 6.3093487815629 YFSLPFCVGSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFSLPFCVGSK 11 0 Q5TB53;Q9HD45 Q5TB53 TM9SF3 Transmembrane 9 superfamily member 3 0 4083000.0 1431700.0 1617200.0 1034100.0 False True 1876972.5646025245 1375920.0637962266 927101.251787638 1.0 0.7330528371828371 0.49393436498309434 20.839976132012325 -6.972429503901775 0.19146167302439862 1.1589983142746678 0.06144658057581958 0.999995650763179 0.00043103999066522745 0.07552194925944368 0.006118567756010949 0.008337580462704422 0.025961877918369087 1.0655418118561995e-07 6.972429503901775 -1.0975517336988483 down YFSLPFCVGSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFSLPFCVGSK 11 0 Q5TB53;Q9HD45 Q5TB53 TM9SF3 Transmembrane 9 superfamily member 3 0 2763600.0 1431700.0 1331900.0 0.0 False True 1961038.1802377186 1273052.2539956886 0.0 1.0 0.6491725999140763 0.0 20.903186193535216 -7.536124068413213 0.7011007153130052 0.9942443774927489 1.1028199207174015e-14 0.987060473162632 0.047122962891201284 0.12018497410977963 0.1438298631321173 0.04195355419187696 0.07621134243884206 2.9098857087558188e-08 7.536124068413213 -0.9942443774927379 down YFSSMAEFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFSSMAEFLK 10 0 Q8WWY3;E7EVX8 Q8WWY3 PRPF31 U4/U6 small nuclear ribonucleoprotein Prp31 0 5792900.0 1579600.0 2087900.0 2125400.0 False True 2070870.8968681619 1776393.4585704547 1905483.9962764194 1.0 0.8578001947185342 0.9201365469755445 20.981806184565947 -10.111699399043749 4.38784310896671 1.0000130663685871 0.888968370842873 0.8087986158048468 0.02544870927361394 35470040.99976098 0.9746811671365752 5035.552466134085 0.0087117700756849 7.732155882661185e-11 10.111699399043749 -0.11104469552571417 YFSSMAEFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFSSMAEFLK 10 0 Q8WWY3;E7EVX8 Q8WWY3 PRPF31 U4/U6 small nuclear ribonucleoprotein Prp31 0 4270400.0 1579600.0 1661500.0 1029300.0 False True 2163620.807084934 1588089.4361542412 786200.5390989196 1.0 0.7339961933042642 0.3633726097125932 21.04501624608884 -6.966454577035548 0.3321446786751419 1.0440393771501946 0.04115759467303234 0.9999400628839744 0.0020211653427931993 0.07747079623454536 0.013138218672356167 0.005367437562118626 0.032271337685926806 1.0803026040828445e-07 6.966454577035548 -1.0028817824771623 down YFSVVWCKPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFSVVWCKPSK 11 1 Q9Y620 Q9Y620 RAD54B DNA repair and recombination protein RAD54B 0 3084600.0 1447600.0 1637000.0 0.0 False True 1897817.6185783432 1392765.9809760232 0.0 1.0 0.7338776747258493 0.0 20.855909924478137 -7.363490382071819 0.7805691594924938 0.9896648727539844 9.716165969263838e-17 0.9877143106618068 0.04687164248308194 0.11011159853651874 0.13814525329965077 0.040339190064852704 0.07194022051873664 4.330216573719012e-08 7.363490382071819 -0.9896648727539843 down YFSVVWCKPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFSVVWCKPSK 11 1 Q9Y620 Q9Y620 RAD54B DNA repair and recombination protein RAD54B 0 4086600.0 1447600.0 1559200.0 1079800.0 False True 1982816.8399190616 1490309.3884151038 824773.479179067 1.0 0.7516122308482804 0.4159604974974562 20.91911998600103 -6.966933754327932 0.3231477224207794 1.0443021381274016 0.11239392919179682 0.9999476362726825 0.0017317667311668625 0.0773107489128035 0.012577956851521748 0.005024545329828545 0.029443765914057937 1.0791113133202147e-07 6.966933754327932 -0.9319082089356048 down YFTCQCGSEK(ub)CK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YFTCQCGSEKCK 12 1 A0A0G2JRR0;A0A0G2JRN8;A0A0G2JIS2;A2ABF8;A0A0G2JIR1;A2ABF9;A0A0G2JK64;Q96KQ7-2;Q96KQ7 A0A0G2JRR0 EHMT2 Histone-lysine N-methyltransferase EHMT2 1 6540200.0 2006300.0 1638200.0 2895700.0 True False 3043703.780177027 1345850.410684981 2323363.625769603 1.0 0.4421752272511565 0.7633343431450719 21.537396528801477 -10.247039609309716 5.739832704123957 1.0000189318039752 0.6027547851981205 0.6710452156991955 0.13111266003059716 3.176567620843961e-05 4.167183718194535e-06 0.1269553289291209 0.04231642906461848 5.6618764821488703e-11 10.247039609309716 -0.39726414660585463 YFTCQCGSEK(ub)CK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFTCQCGSEKCK 12 1 A0A0G2JRR0;A0A0G2JRN8;A0A0G2JIS2;A2ABF8;A0A0G2JIR1;A2ABF9;A0A0G2JK64;Q96KQ7-2;Q96KQ7 A0A0G2JRR0 EHMT2 Histone-lysine N-methyltransferase EHMT2 1 6600000.0 2006300.0 2427600.0 2166100.0 True False 2597194.9000854916 2292501.925968097 1771892.0260628867 1.0 0.8826838239566215 0.6822329837489521 21.308522850893926 -6.963003062049289 0.3908135026834194 1.012199924033458 0.5455050959608378 0.999865876527684 0.0015194312334889703 0.07864530356721419 0.017291264312961113 0.0025868993065667895 0.01685576696097281 1.0889224157183538e-07 6.963003062049289 -0.4666948280726202 YFTLGLPTGSTPLGCYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFTLGLPTGSTPLGCYK 17 0 D6RAY7;D6R9P4;P46926;D6RB13;D6R917;P46926-2;Q8TDQ7-3;Q8TDQ7-2;Q8TDQ7 D6RAY7 GNPDA1;GNPDA2 Glucosamine-6-phosphate isomerase;Glucosamine-6-phosphate isomerase 1;Glucosamine-6-phosphate isomerase 2 0 23011600.0 6294500.0 10787000.0 5930100.0 False True 8252150.456024702 9177621.647396674 5316510.137535902 1.0 1.1121490932943798 0.6442575381856305 22.97633869449694 -6.843433563691454 1.266356411793687 1.0596602441986642 0.6277923972197238 0.930197566203299 0.05269718990566054 0.16482644061670035 0.5119642687624739 0.032610289070380015 0.07521138668850755 1.4340570745219582e-07 6.843433563691454 -0.43186784697894043 YFTLGLPTGSTPLGCYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YFTLGLPTGSTPLGCYK 17 0 D6RAY7;D6R9P4;P46926;D6RB13;D6R917;P46926-2;Q8TDQ7-3;Q8TDQ7-2;Q8TDQ7 D6RAY7 GNPDA1;GNPDA2 Glucosamine-6-phosphate isomerase;Glucosamine-6-phosphate isomerase 1;Glucosamine-6-phosphate isomerase 2 0 25585500.0 17551000.0 4464600.0 3569900.0 False True 16993853.111931693 6247338.062581431 2634836.095295626 1.0 0.36762340014549505 0.155046420487515 24.018509664186983 -11.423708592567916 0.20077018792756254 2.2157173217951964 1.44724295454102e-23 0.9993770570068904 0.008956765665624037 3.940119327937787 0.11878258501169771 2.2324873616213536 0.13140225277298476 3.7695664844039365e-12 11.423708592567916 -2.2157173217951964 YFTLGLPTGSTPLGCYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFTLGLPTGSTPLGCYK 17 0 D6RAY7;D6R9P4;P46926;D6RB13;D6R917;P46926-2;Q8TDQ7-3;Q8TDQ7-2;Q8TDQ7 D6RAY7 GNPDA1;GNPDA2 Glucosamine-6-phosphate isomerase;Glucosamine-6-phosphate isomerase 1;Glucosamine-6-phosphate isomerase 2 0 42518500.0 6294500.0 12404000.0 23820000.0 False True 8621746.752466504 11855950.265457248 18194206.58829907 1.0 1.375121608862555 2.1102691960992805 23.03954875601983 -6.96044040336215 0.4291814167947229 0.9705440173985591 2.543000463829966 0.9997861870668169 0.006742953856252966 0.07954416810885725 0.020552743942766873 0.00957872443029648 0.06105169154556004 1.0953668582276002e-07 6.96044040336215 1.572456446431407 up YFTLGLPTGSTPLGCYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YFTLGLPTGSTPLGCYK 17 0 D6RAY7;D6R9P4;P46926;D6RB13;D6R917;P46926-2;Q8TDQ7-3;Q8TDQ7-2;Q8TDQ7 D6RAY7 GNPDA1;GNPDA2 Glucosamine-6-phosphate isomerase;Glucosamine-6-phosphate isomerase 1;Glucosamine-6-phosphate isomerase 2 0 27547000.0 17551000.0 1761100.0 8234900.0 False True 14594434.14113273 1751612.6047490211 9956779.51612439 1.0 0.12001922019109347 0.6822312821339441 23.79891493962126 -10.085230738077906 6.557336717740029 1.0000006010159521 0.4011252513901889 0.6020535142584278 0.22952211316633744 2.0164358572473084e-06 2.8129296045779965e-07 0.22223405232465973 0.07407794348996247 8.218059133405055e-11 10.085230738077906 -0.5988753496257633 YFTLGLPTGSTPLGCYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFTLGLPTGSTPLGCYK 17 0 D6RAY7;D6R9P4;P46926;D6RB13;D6R917;P46926-2;Q8TDQ7-3;Q8TDQ7-2;Q8TDQ7 D6RAY7 GNPDA1;GNPDA2 Glucosamine-6-phosphate isomerase;Glucosamine-6-phosphate isomerase 1;Glucosamine-6-phosphate isomerase 2 0 20234400.0 4669300.0 8277700.0 7287400.0 False True 6044500.895663258 7817038.718316905 5961167.9750384 1.0 1.2932480039709133 0.9862134323307576 22.527191788024584 -6.6565519951363745 1.9848441667411614 1.1892878358611352 0.9874912706068036 0.2212076314627437 0.12496076493328194 0.4926431179758507 3.727113446514078 0.05092608636909143 0.13850309264840313 2.205200106917226e-07 6.6565519951363745 -0.20179656525433154 YFVK(ub)DVLGCVCVNPGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YFVKDVLGCVCVNPGR 16 1 Q14181 Q14181 POLA2 DNA polymerase alpha subunit B 1 22580400.0 3229500.0 5499900.0 13851000.0 True False 4180651.4129622155 5193825.73019934 11330260.123261636 1.0 1.2423484326140544 2.7101661927927974 21.995296324316723 -6.935637089678669 0.6989808204987287 0.9816427349033461 3.0598620263243874 0.9975346675317223 0.03751534071140151 0.08981468147283575 0.06410496677059194 0.03540765284472281 0.12894568768606185 1.1597460721629089e-07 6.935637089678669 2.0782192914210413 up YFVQGMGYMPSASMTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFVQGMGYMPSASMTR 16 0 Q92597;Q92597-3;Q92597-2;E5RJY1;E7ESM1 Q92597 NDRG1 Protein NDRG1 0 11579200.0 5711600.0 4188000.0 1679600.0 False True 7487962.911213085 3563166.724696141 1505811.1038608616 1.0 0.47585261398134937 0.20109756441313797 22.836141858419975 -9.014150242766327 0.23913871552296082 1.3342610443040435 2.2430811766965305e-23 0.9992675889659689 0.008968853807679531 0.4763578249737092 0.08041651651043989 0.24880865305375807 0.11844326545552 9.679429416144908e-10 9.014150242766327 -1.3342610443040435 YFVQGMGYMPSASMTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YFVQGMGYMPSASMTR 16 0 Q92597;Q92597-3;Q92597-2;E5RJY1;E7ESM1 Q92597 NDRG1 Protein NDRG1 0 12731100.0 6066800.0 1327900.0 5336400.0 False True 5874212.754798431 1858137.394907018 3938636.7514315736 1.0 0.31632109228409766 0.6704961014927906 22.485964088091144 -10.651712023746576 6.748792320107932 1.0022601361212093 0.49340859688897154 0.7317479835980587 0.14459134203447185 0.004932893617360054 0.0002545736773652498 0.1404510089724732 0.04666665497544082 2.229913291967278e-11 10.651712023746576 -0.5088515392322378 YFVQGMGYMPSASMTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFVQGMGYMPSASMTR 16 0 Q92597;Q92597-3;Q92597-2;E5RJY1;E7ESM1 Q92597 NDRG1 Protein NDRG1 0 14054900.0 5711600.0 3667800.0 4675500.0 False True 7823332.870186315 3505744.4682073584 3571243.194945108 1.0 0.4481139338410725 0.4564861618702999 22.899351919942866 -10.085482497568005 5.028920209010106 1.000013753342727 0.4523000478592115 0.999824780235741 0.003417947787638571 5.283981816440649e-07 9.6085027434374e-08 0.0033094969418789423 0.0011031379039270102 8.213296524416697e-11 10.085482497568005 -0.5477137054835154 YFVQGMGYMPSASMTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YFVQGMGYMPSASMTR 16 0 Q92597;Q92597-3;Q92597-2;E5RJY1;E7ESM1 Q92597 NDRG1 Protein NDRG1 0 10577000.0 6066800.0 2310700.0 2199500.0 False True 5044813.004810216 2298251.8004619614 2659405.280661036 1.0 0.45556729224068054 0.5271563639970995 22.26636936352542 -10.532198086951878 6.285620362234702 1.0005834232329511 0.49136182811917567 0.9853603090659431 0.02922611616045289 0.00023920570418332985 1.780266725858924e-05 0.028328495238689695 0.009432688430313118 2.936310060045081e-11 10.532198086951878 -0.5092215951137755 YFVTFPYPYMNGR ddPTM_RPMI8226_Bortezomib_1h_R1 2 YFVTFPYPYMNGR 13 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 28733200.0 7210200.0 14035800.0 7487200.0 False True 9452642.023676125 11941713.351119872 6712496.366293779 1.0 1.2633201724141616 0.7101185414068282 23.172286189846016 -6.777250871079127 1.5463996516609735 1.1496300683192113 0.7060941773920197 0.7576050006446204 0.11123371826109414 0.2548684219688745 1.20360843954045 0.05666344083118176 0.13402258622227428 1.6701255842159913e-07 6.777250871079127 -0.4435358909271916 YFVTFPYPYMNGR ddPTM_RPMI8226_Bortezomib_2h_R1 2 YFVTFPYPYMNGR 13 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 30571050.0 13560950.0 5679700.0 11330400.0 False True 13130465.065138739 7947633.829244226 8362628.335286005 1.0 0.6052819751483989 0.6368874441080312 23.646414679854914 -10.074120129556833 5.318529628867124 1.000004510477001 0.621084709627804 0.994809116012747 0.012902878673518057 6.900884877522984e-07 1.201319157042031e-07 0.012493307260361497 0.004164386184848025 8.43101516439094e-11 10.074120129556833 -0.37891980084919696 YFVTFPYPYMNGR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 YFVTFPYPYMNGR 13 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 36284220.0 7210200.0 11138600.0 17935420.0 False True 9876005.788328549 10646459.821575467 13699443.187569732 1.0 1.0780127158448447 1.387144102705946 23.235496251368907 -6.9450912232747966 0.6103689900255153 0.9965824573929077 1.484682981190175 0.9987575063949596 0.005892769290913808 0.08551893909162639 0.04459716391533143 0.005987776965639812 0.026070096205507678 1.1347724324221978e-07 6.9450912232747966 0.4881005237972672 YFVTFPYPYMNGR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 YFVTFPYPYMNGR 13 0 A0A6I8PIT3;A0A6I8PIV1;Q9P2J5;A0A6I8PLB8;A0A6I8PL42;B4DER1;A0A6I8PIP7;A0A6I8PTV8;A0A6I8PRU9 A0A6I8PIT3 LARS Leucine--tRNA ligase, cytoplasmic 0 27995150.0 13560950.0 8548200.0 5886000.0 False True 11276530.776946831 8502149.149915157 7116735.386210891 1.0 0.753968513729109 0.6311103589376961 23.42681995528919 -13.999999993283469 0.09021458963959267 2.258625889380455 0.3246757152367961 0.9998414034584862 0.0019314764163742395 12.1617503947806 0.08732185728640215 2.9334084175962127 0.2752698057444152 1.000000015465385e-14 13.999999993283469 -1.9339501741436589 YFYTAMSRPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFYTAMSRPGR 11 1 D9J307;A0A140T953;Q2L6G2;D5H3J5;A0A140TA13;A0A140TA14;A0A140TA11;A0A140T9Y5;A0A140T997 D9J307 HLA-B 0 5392200.0 1676700.0 1267900.0 2447600.0 False True 2198169.937185899 1078734.2622354913 2194345.8310370585 1.0 0.49074197767279487 0.9982603227875384 21.067871492489548 -10.920966420476493 10.535846254993155 1.0375580733460925 0.7445011502302059 0.2525708283637407 0.20719349677214288 0.11465744040400358 0.0008600898662766142 0.12583839827139834 0.06687141353674914 1.1995920516735511e-11 10.920966420476493 -0.2930569231158866 YFYTAMSRPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFYTAMSRPGR 11 1 D9J307;A0A140T953;Q2L6G2;D5H3J5;A0A140TA13;A0A140TA14;A0A140TA11;A0A140T9Y5;A0A140T997 D9J307 HLA-B 0 4624100.0 1676700.0 1321000.0 1626400.0 False True 2296621.3011137675 1262633.8520371688 1242277.816759432 1.0 0.5497788649024734 0.5409153943477656 21.13108155401244 YFYTAVSRPGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFYTAVSRPGR 11 1 O78179;A0A140T912;A0A1W2PRZ0;A0A140T930;A0A140T937;A0A140T9M5;A0A140T9S7;A0A140T9Z4;A0A140T9Q4;A0A140TA19;A0A0G2JKJ1;A0A140TA03;Q53YP1;A0A140T9M0;A0A140T9W2;A0A140T9U0;A0A140T9T1 O78179;Q53YP1 HLA-C 0 2504400.0 0.0 1100900.0 1403500.0 False True 0.0 936650.0112745883 1258279.2833226481 0.0 YFYTAVSRPGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFYTAVSRPGR 11 1 O78179;A0A140T912;A0A1W2PRZ0;A0A140T930;A0A140T937;A0A140T9M5;A0A140T9S7;A0A140T9Z4;A0A140T9Q4;A0A140TA19;A0A0G2JKJ1;A0A140TA03;Q53YP1;A0A140T9M0;A0A140T9W2;A0A140T9U0;A0A140T9T1 O78179;Q53YP1 HLA-C 0 2971800.0 0.0 1326300.0 1645500.0 False True 0.0 1267699.680512412 1256866.790136277 0.0 YFYVSAEQVVQGMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YFYVSAEQVVQGMK 14 0 O95881 O95881 TXNDC12 Thioredoxin domain-containing protein 12 0 7163300.0 2656400.0 2707900.0 1799000.0 False True 3482566.124614195 2303891.875311526 1612856.737226536 1.0 0.6615500733864043 0.4631230763508363 21.731719315330114 -9.766891805993565 0.11441489528839328 1.7222551068429743 5.469942841622786e-12 0.9999028510736221 0.002184666753832152 1.27888395092404 0.04949986669244068 0.5142724265827769 0.23683969036907465 1.7104413772749257e-10 9.766891805993565 -1.7222551068375045 YFYVSAEQVVQGMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YFYVSAEQVVQGMK 14 0 O95881 O95881 TXNDC12 Thioredoxin domain-containing protein 12 0 15703000.0 4275100.0 6501300.0 4926600.0 False True 4139389.2905714307 9097302.993831616 3636175.665168047 1.0 2.197740380338994 0.878432882225021 21.980986503122335 -6.6676674843364285 1.9453679011340421 1.7660186727056262 0.8837810355893178 0.2689063691978445 0.5090448129858145 0.4664730244436455 3.4010620545986656 0.21081478470259618 0.5650192310250624 2.149475580808336e-07 6.6676674843364285 -0.8822376371163084 YFYVSAEQVVQGMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YFYVSAEQVVQGMK 14 0 O95881 O95881 TXNDC12 Thioredoxin domain-containing protein 12 0 10329000.0 2656400.0 2879100.0 4793500.0 False True 3638542.866510772 2751891.842089487 3661374.025231393 1.0 0.7563170046498446 1.0062748082290742 21.794929376853005 -11.045804388276466 10.342865543734787 1.3533575094899402 0.8812959064394607 0.231184559428529 0.10204484599932254 0.047452156711219454 0.00021014671240959952 0.005638784406327721 0.032934832426806386 8.999028178641015e-12 11.045804388276466 -0.4720616030504795 YFYVSAEQVVQGMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YFYVSAEQVVQGMK 14 0 O95881 O95881 TXNDC12 Thioredoxin domain-containing protein 12 0 10392200.0 4275100.0 3451900.0 2665200.0 False True 3554935.0690420223 3433303.929551501 3222480.9975075223 1.0 0.9657852711432791 0.9064809722040608 21.76139177855661 -6.962745954069306 0.3948603343668372 1.0034507110111368 0.8666680818781274 0.9998588054723327 0.00045903649477332687 0.07873479284948942 0.01761308072720711 0.0007639955361276922 0.004978579339779791 1.0895672628067225e-07 6.962745954069306 -0.13678262913300943 YGAAMALGICCAGTGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGAAMALGICCAGTGNK 17 0 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 20071400.0 6173700.0 6927000.0 6970700.0 False True 8093780.486195846 5893518.60123452 6249438.831675936 1.0 0.7281539956866967 0.772128530336907 22.948382291105027 -10.197522058397865 5.334814307495456 1.0000130804816538 0.7501412630117774 0.9772960778898949 0.017952528595085112 2.7931559942295447e-06 4.201206602126105e-07 0.017383370580339716 0.005794153689228564 6.345676696217017e-11 10.197522058397865 -0.2498718174698764 YGAAMALGICCAGTGNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGAAMALGICCAGTGNK 17 0 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 41639000.0 7416000.0 18195000.0 16028000.0 False True 11250614.182222417 14947960.091816124 12860058.77467803 1.0 1.3286350282490393 1.1430539316687942 23.423500425961414 -10.228921360872889 4.226595413783811 0.9998711931451087 1.2358444799691486 0.6828809630328881 0.07576316546045274 9.278449476273656e-05 1.6927092430057015e-05 0.0733976523607727 0.024452456501565883 5.903079594945633e-11 10.228921360872889 0.23597328682403984 YGAAMALGICCAGTGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGAAMALGICCAGTGNK 17 0 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 18801600.0 6173700.0 5939700.0 6688200.0 False True 8456283.72796926 5677264.414038731 5108584.907802771 1.0 0.6713663586358993 0.604117017846275 23.01159235262792 -13.999999999999973 0.2230178720230106 3.009761878846463 0.5691691479396782 0.999501094803644 0.003863330005684506 13.083474487278744 0.14958088977562203 11.59886858644315 0.03649038812174166 1.0000000000000614e-14 13.999999999999973 -2.4405927309067845 YGAAMALGICCAGTGNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGAAMALGICCAGTGNK 17 0 Q99460;A0A087WW66;Q99460-2;H7C378 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 32016500.0 7416000.0 15423000.0 9177500.0 False True 9600158.191214677 14564696.492093401 7507289.169102126 1.0 1.5171308849287386 0.7819964025147228 23.194626748053864 -6.717690296270759 1.767970893477681 1.3153950327952513 0.7833143582875779 0.5014578006445818 0.21767441309088942 0.3598148122633657 2.1967913138943285 0.09781547612014442 0.24619102769121204 1.9156215045087603e-07 6.717690296270759 -0.5320806745076734 YGAFGLPITVAHVDGQTHMLFGSDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGAFGLPITVAHVDGQTHMLFGSDR 25 0 Q9Y2Q3;Q9Y2Q3-4;Q9Y2Q3-3;Q9Y2Q3-2 Q9Y2Q3 GSTK1 Glutathione S-transferase kappa 1 0 13335100.0 5582700.0 2574900.0 5177500.0 False True 5405480.244315486 3603070.997926115 3821357.4283293895 1.0 0.666558905976056 0.7069413364979008 22.365991367730697 -10.413303088429341 9.023288156243568 1.000001592046012 0.6867501213756945 0.987689243909817 0.016486058225318848 5.280095457882554e-07 3.4322044669207514e-08 0.015962638331060666 0.005320852412605476 3.8609743066986175e-11 10.413303088429341 -0.31325147067031744 YGAFGLPITVAHVDGQTHMLFGSDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGAFGLPITVAHVDGQTHMLFGSDR 25 0 Q9Y2Q3;Q9Y2Q3-4;Q9Y2Q3-3;Q9Y2Q3-2 Q9Y2Q3 GSTK1 Glutathione S-transferase kappa 1 0 45352000.0 11364000.0 14583000.0 19405000.0 False True 17240018.819683883 11980549.71250096 15569593.244486341 1.0 0.6949267189211014 0.9031076710142378 24.039258013525426 -10.081267589857404 5.082295971997631 1.000004304164773 0.7990171959713082 0.5541135867907334 0.08498951780133239 4.1449870788085735e-06 7.491889569781822e-07 0.08229250866657618 0.027430248920252004 8.293396137673822e-11 10.081267589857404 -0.20098710819346488 YGAFGLPITVAHVDGQTHMLFGSDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGAFGLPITVAHVDGQTHMLFGSDR 25 0 Q9Y2Q3;Q9Y2Q3-4;Q9Y2Q3-3;Q9Y2Q3-2 Q9Y2Q3 GSTK1 Glutathione S-transferase kappa 1 0 13344500.0 5582700.0 3161600.0 4600200.0 False True 4642262.405543942 3144567.8332715365 5562080.55107839 1.0 0.677378303629754 1.1981400586998208 22.146396643164973 -6.739137836122949 1.6898136474956302 0.8078481917424026 1.1983898688221202 0.601056475702539 0.1355551836997866 0.31939149268579137 1.7904035314071738 0.06346919727559587 0.15589770232777084 1.8233169272428667e-07 6.739137836122949 0.39054167707971754 YGAFGLPITVAHVDGQTHMLFGSDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGAFGLPITVAHVDGQTHMLFGSDR 25 0 Q9Y2Q3;Q9Y2Q3-4;Q9Y2Q3-3;Q9Y2Q3-2 Q9Y2Q3 GSTK1 Glutathione S-transferase kappa 1 0 41540000.0 11364000.0 15470000.0 14706000.0 False True 14710922.017929303 14609080.900777085 12029658.896302467 1.0 0.9930771764660232 0.8177365689003735 23.810384335617876 -6.915223919986508 0.8593945712683203 1.0045737407789808 0.7923493036670699 0.9927482650701853 0.007181761616382816 0.10106417570248653 0.12077657480192494 0.006036122195824982 0.017332145216073024 1.215559103067142e-07 6.915223919986508 -0.21222443711191086 YGASLLHTYAGPSLLVLGPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGASLLHTYAGPSLLVLGPR 20 0 A0A0D9SFK2;Q92614-2;Q92614-3;Q92614-4;Q92614;H0YEV9 A0A0D9SFK2 MYO18A Unconventional myosin-XVIIIa 0 33493300.0 13153000.0 9827300.0 10513000.0 False True 12735465.214588186 13751392.13869247 7759329.916760375 1.0 1.079771481212996 0.6092694523535928 23.60234832508165 -6.863257959805314 1.1690811522817846 1.0437191821004834 0.5850169851068222 0.9574836580480395 0.04239165494682301 0.14348799491517872 0.3708055424350878 0.02824051146354554 0.06618657692022337 1.3700677392666635e-07 6.863257959805314 -0.4587021969936612 YGASLLHTYAGPSLLVLGPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGASLLHTYAGPSLLVLGPR 20 0 A0A0D9SFK2;Q92614-2;Q92614-3;Q92614-4;Q92614;H0YEV9 A0A0D9SFK2 MYO18A Unconventional myosin-XVIIIa 0 33507800.0 4631500.0 9422300.0 19454000.0 False True 6343890.711581326 9005991.630620588 14859365.867706565 1.0 1.4196322162642814 2.3423111373245282 22.59693648676932 -6.958150624150408 0.460764775462142 0.973309955131961 2.8258756695453795 0.9996953181149584 0.009786690780655189 0.08036859126444791 0.02362386520275302 0.012547384381586021 0.07621619148164682 1.1011573344978519e-07 6.958150624150408 1.8525657144134184 up YGASLLHTYAGPSLLVLGPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGASLLHTYAGPSLLVLGPR 20 0 A0A0D9SFK2;Q92614-2;Q92614-3;Q92614-4;Q92614;H0YEV9 A0A0D9SFK2 MYO18A Unconventional myosin-XVIIIa 0 30366900.0 13153000.0 8237700.0 8976200.0 False True 10937302.27669754 8193321.875044564 10853081.918740455 1.0 0.7491172565012524 0.9922997137844017 23.382753600515926 -10.706997783581942 8.908515264236193 1.000317216162121 0.8707084851685278 0.2737254250235299 0.09927882245664713 0.0006269966419879133 2.062197329887102e-05 0.09635809918781671 0.03204210216713978 1.963370296853472e-11 10.706997783581942 -0.12960873099359316 YGDESSNSLPGHSVALCLAVAFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGDESSNSLPGHSVALCLAVAFK 23 0 Q09161 Q09161 NCBP1 Nuclear cap-binding protein subunit 1 0 41418000.0 12856000.0 14626000.0 13936000.0 False True 19503491.899494506 12015876.02654041 11181543.4916342 1.0 0.6160884465438642 0.5733098231462851 24.217229111010976 -13.999999999999998 0.3098080152435904 4.7068500598739975 0.5638166517140863 0.999671573635105 0.00347693414892372 17.256162210608593 0.1770941808713905 41.230516241176986 0.014836036125021608 1.0000000000000041e-14 13.999999999999998 -4.143033408159911 YGDESSNSLPGHSVALCLAVAFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGDESSNSLPGHSVALCLAVAFK 23 0 Q09161 Q09161 NCBP1 Nuclear cap-binding protein subunit 1 0 30559700.0 12856000.0 7524700.0 10179000.0 False True 16642345.42964614 7105943.830257098 8326526.445359906 1.0 0.4269797102996551 0.5003216932709076 23.988355433103425 -10.535356120155065 6.298123907469557 1.000635423084772 0.46365070178575896 0.9861699764858756 0.029941739167243606 0.00026744234194550685 1.973056653655581e-05 0.029022834814227367 0.009663654762601732 2.9150357132812465e-11 10.535356120155065 -0.5369847212990131 YGDFNK(ub)EVHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGDFNKEVHK 10 1 P26038 P26038 MSN Moesin 1 10565180.0 4669000.0 4080580.0 1815600.0 True False 6121104.214660316 3471773.3699762556 1627739.1284649784 1.0 0.5671808955092129 0.26592246617309195 22.545360500235148 -8.157061253809223 0.24475666491072776 1.2006888339077044 1.971241511881729e-13 0.9995616080426223 0.0063082651859431875 0.08825157236474647 0.05081783413553239 0.08651537501749275 0.1027758196378828 6.965282673673523e-09 8.157061253809223 -1.2006888339075072 down YGDFNK(ub)EVHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGDFNKEVHK 10 1 P26038 P26038 MSN Moesin 1 17204320.0 6750170.0 6740050.0 3714100.0 True False 6535889.548206255 9431387.113896426 2741265.7893883516 1.0 1.4430150699968343 0.4194173982240382 22.63995217251378 -6.789076946692349 1.4998632136589702 1.247907703761602 0.40878635006716446 0.7983271482497972 0.18822653927544053 0.23675418315722818 1.052162072548833 0.09878090883306746 0.231442245693242 1.625260772538139e-07 6.789076946692349 -0.8391213536944375 down YGDFNK(ub)EVHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGDFNKEVHK 10 1 P26038 P26038 MSN Moesin 1 32219800.0 9704200.0 9378100.0 13137500.0 True False 14721980.87204998 7704504.783570267 10540867.366629193 1.0 0.5233334325408239 0.7159951815072163 23.811468466178034 -10.182081964189033 5.380688004495532 1.0000151079423927 0.6196643070239399 0.8386095295289919 0.07865382965358947 1.4255491222500906e-05 2.166803816479061e-06 0.07615926586265125 0.02538541436360818 6.575337296193316e-11 10.182081964189033 -0.38035080091845275 YGDFNK(ub)EVHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGDFNKEVHK 10 1 P26038 P26038 MSN Moesin 1 11384970.0 4669000.0 4384070.0 2331900.0 True False 6395255.4749807175 4190367.291219223 1781153.24698802 1.0 0.6552306327108625 0.27851166446065867 22.60857056175804 -7.355748390214497 0.3217877817684799 1.0664494507047677 1.6203869744666797e-13 0.9997583543100641 0.004580203396539535 0.11074074931388703 0.026182412774440406 0.014913833913522669 0.05416700018608897 4.408101742129149e-08 7.355748390214497 -1.0664494507046056 down YGDFNK(ub)EVHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGDFNKEVHK 10 1 P26038 P26038 MSN Moesin 1 22803770.0 6750170.0 13668300.0 2385300.0 True False 5613065.438234285 13594666.154954873 2884055.2016189033 1.0 2.4219682283325343 0.5138110776285814 22.420357447948057 -6.707154808077395 1.8051420472431903 1.8766900105431679 0.518601947687855 0.4517500263860351 0.5994781241246491 0.3807801741687796 2.4168421904827952 0.26444674757106396 0.674198719610495 1.9626605445644372e-07 6.707154808077395 -1.358088062855313 YGDFNK(ub)EVHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGDFNKEVHK 10 1 P26038 P26038 MSN Moesin 1 25293670.0 9704200.0 8597770.0 6991700.0 True False 12562278.198379902 8119296.541452749 5719282.340900173 1.0 0.6463235738960037 0.4552742942468638 23.582594788270484 -11.358739457413144 0.10281463277565842 2.088158954395964 6.50899204130777e-11 0.999870052839584 0.002572421355516865 4.065235497848304 0.06669226087631412 1.3250561057542667 0.31144295429383584 4.377846628147311e-12 11.358739457413144 -2.0881589543308743 YGDGGSSFQSTTGHCVHMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGDGGSSFQSTTGHCVHMR 19 0 P55795 P55795 HNRNPH2 Heterogeneous nuclear ribonucleoprotein H2 0 4329180.0 661480.0 1465800.0 2201900.0 False True 867206.6857814321 1247108.353643648 1974068.510116237 1.0 1.438075114146393 2.2763529646192957 19.726016353714545 -6.960899782457092 0.42256145483910645 0.9639525722975915 2.78223070847504 0.9998021286334735 0.007448840069448593 0.079381252899768 0.019955172446675124 0.010862707000825837 0.0697318112590827 1.0942088361378486e-07 6.960899782457092 1.8182781361774487 up YGDGGSTFQSTTGHCVHMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGDGGSTFQSTTGHCVHMR 19 0 P31943;G8JLB6;E9PCY7;H0YB39;D6RIT2;H0YBD7;H0YBG7 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 34943200.0 8032400.0 15225100.0 11685700.0 False True 10530554.18587225 12953574.426974962 10476575.861149604 1.0 1.230094275983445 0.9948741230736875 23.328078026517357 -6.651135875691219 2.0038694157386163 1.1491655848079523 0.9958496272419644 0.19897525719583142 0.09817756834946674 0.5057072774710828 3.893411119983936 0.03971100956174417 0.10879221095950763 2.2328735248000593e-07 6.651135875691219 -0.15331595756598793 YGDGGSTFQSTTGHCVHMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGDGGSTFQSTTGHCVHMR 19 0 P31943;G8JLB6;E9PCY7;H0YB39;D6RIT2;H0YBD7;H0YBG7 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 125738400.0 10160400.0 110700000.0 4878000.0 False True 15414069.624737415 90944720.09695229 3913861.1618966456 1.0 5.900110892907788 0.2539148490425558 23.87774447689471 -6.67722580097993 1.9117151367383607 4.108034356073849 0.2758326292631382 0.3114859573149461 2.078052798295549 0.44471696525784415 3.1398643036440173 0.8729992356866579 2.3107170121943197 2.1026849150203253e-07 6.67722580097993 -3.8322017268107103 YGDGGSTFQSTTGHCVHMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGDGGSTFQSTTGHCVHMR 19 0 P31943;G8JLB6;E9PCY7;H0YB39;D6RIT2;H0YBD7;H0YBG7 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 30474600.0 8032400.0 9946700.0 12495500.0 False True 11002195.34744809 9507221.904661704 9544320.252900548 1.0 0.8641204418231732 0.8674923459811419 23.39128808804025 -10.33984963374092 8.034128532210566 1.0000006668051271 0.8658063939021625 0.9995266851910846 0.0013765741080987257 1.644063026699763e-08 1.3522537910403441e-09 0.0013328687624752573 0.0004442873829572304 4.5724647516470965e-11 10.33984963374092 -0.1341942729029646 YGDGGSTFQSTTGHCVHMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGDGGSTFQSTTGHCVHMR 19 0 P31943;G8JLB6;E9PCY7;H0YB39;D6RIT2;H0YBD7;H0YBG7 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 27619200.0 10160400.0 8530000.0 8928800.0 False True 13152838.091426324 8055298.001527383 7303850.0172246415 1.0 0.6124380111375527 0.5553060082132125 23.648870798987158 -13.999999999999998 0.26960719980758874 3.9850454854002173 0.5362695223128339 0.9995824838848973 0.004036502506810358 14.863722386435205 0.16436539702261097 24.31297173590311 0.023774670025919428 1.0000000000000041e-14 13.999999999999998 -3.4487759630873835 YGDSEFTVQSTTGHCVHMR ddPTM_RPMI8226_Bortezomib_1h_R1 2 YGDSEFTVQSTTGHCVHMR 19 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 57074600.0 16679600.0 20938500.0 19456500.0 False True 21867117.125476174 17814557.41763373 17443328.01992667 1.0 0.8146733433315254 0.7976967388903958 24.38225969790677 -13.99999999999802 0.3382311017232472 3.1205171484634446 0.7949723719595212 0.9997316576534716 0.0015009574065017412 19.542327141056425 0.1864423575420708 29.60275167175072 0.0052784218052388775 1.0000000000045606e-14 13.99999999999802 -2.325544776503923 YGDSEFTVQSTTGHCVHMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGDSEFTVQSTTGHCVHMR 19 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 90391400.0 12781500.0 70447800.0 7162100.0 False True 19390469.952814966 57875839.678826384 5746507.795740059 1.0 2.984756935735041 0.2963573244858783 24.208844433637648 -6.708969910024712 1.7991556777666922 2.2215332629250337 0.30297925231708706 0.459969652962959 0.8365113611055693 0.37721273876043226 2.379594410067603 0.3701107792180658 0.9413334747045036 1.9544748663449632e-07 6.708969910024712 -1.9185540106079466 YGDSEFTVQSTTGHCVHMR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 YGDSEFTVQSTTGHCVHMR 19 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 47215440.0 16679600.0 11015740.0 19520100.0 False True 22846498.869241472 10529028.182619156 14909854.40907879 1.0 0.46085959353686873 0.652610034229451 24.44546975942966 -10.207804700933416 4.996163648198676 1.0000488343596319 0.5567348138826754 0.8769251571528566 0.07828178961012594 110145023.36870307 4.943636469097525 61879.0216772094 0.02679793875683061 6.1971969586051e-11 10.207804700933416 -0.44331402047695645 YGDSEFTVQSTTGHCVHMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGDSEFTVQSTTGHCVHMR 19 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 7367900.0 2894600.0 1997400.0 2475900.0 False True 2406988.1525225234 1986639.6097471397 2993599.2427318357 1.0 0.8253632688906847 1.243711664967916 21.19879761004017 -6.79330369719058 1.4829475652295243 0.9028133504329793 1.2485851647689639 0.8119012397233206 0.07440803875942993 0.23045892768886714 1.0010855013929414 0.039485747646850235 0.09223478015275559 1.6095197227233626e-07 6.79330369719058 0.3457718143359846 YGDSEFTVQSTTGHCVHMR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGDSEFTVQSTTGHCVHMR 19 0 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 0 39292300.0 12781500.0 16210800.0 10300000.0 False True 16545903.711031603 15308654.72956155 8425505.68692475 1.0 0.9252232453978839 0.5092200362139928 23.979970755730097 -6.937454711148963 0.682829951785842 1.0049385791403742 0.4049660849289263 0.9978111848646266 0.010100830179985146 0.08894718933440364 0.06004232993733289 0.009652224391441741 0.03622432326738598 1.154902413289069e-07 6.937454711148963 -0.5999724942114479 YGEDGLAGESVEFQNLATLK(ub)PSNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGEDGLAGESVEFQNLATLKPSNK 24 1 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 61577900.0 2573400.0 9914500.0 49090000.0 True False 3904035.940740445 8145180.012657939 39387339.983088635 1.0 2.0863486239097258 10.08887740301345 21.896534903805232 -6.931664697087663 0.7329979589525539 0.8855098204521322 11.803646151181823 0.9968554418397616 0.2272675189500819 0.09178259842458045 0.07351259663640083 0.20914090166654004 0.7175772649455147 1.170402667446936e-07 6.931664697087663 10.918136330729691 YGEDGLAGESVEFQNLATLK(ub)PSNKAFEKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGEDGLAGESVEFQNLATLKPSNKAFEKK 29 3 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 2 21659600.0 3411800.0 8572600.0 9675200.0 True False 4472902.839918196 7293601.495733086 8674103.115071813 1.0 1.630619254825235 1.9392558759962806 22.09277998988654 -10.191455446515958 0.15903101858541493 1.2166402657974736e-19 2.3475942214478733 0.9996606302870452 0.007200927124038724 1.8335931464244843 0.07761612001314724 1.004565762202633 0.2552020267897502 6.434940764976608e-11 10.191455446515958 2.3475942214478733 YGEDGLAGESVEFQNLATLKPSNK(ub)AFEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGEDGLAGESVEFQNLATLKPSNKAFEK 28 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 25066200.0 5538400.0 4269800.0 15258000.0 True False 5362586.523566891 5974753.406712846 11261472.069811659 1.0 1.1141551526405538 2.100007528143557 22.354497589533345 -6.928700436147215 0.757379791425318 0.9842638255273537 2.2958615989917677 0.99627676072596 0.03013365490368377 0.09331784097030839 0.08102594903584746 0.027244128659309905 0.08984818934346701 1.1784185324867866e-07 6.928700436147215 1.311597773464414 up YGEDGLAGESVEFQNLATLKPSNK(ub)AFEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGEDGLAGESVEFQNLATLKPSNKAFEK 28 2 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 1 102136000.0 16084000.0 19651000.0 66401000.0 True False 20821055.063038953 18557404.575382702 54316699.33179527 1.0 0.8912807021160696 2.6087390464769 24.311539840228694 -6.891805934856992 1.011611377628955 0.9116746565564353 2.7618060401540725 0.9820301626473376 0.10526371645593674 0.11769115929931766 0.21337364505976555 0.07908932811638093 0.19850230950767703 1.282903722051813e-07 6.891805934856992 1.8501313835976372 up YGEDGLAGESVEFQNLATLKPSNK(ub)AFEKK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGEDGLAGESVEFQNLATLKPSNKAFEKK 29 3 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 2 34327000.0 3643900.0 16422100.0 14261000.0 True False 3528226.3890700163 22979530.17012016 10525616.279170526 1.0 6.513054332711682 2.9832598927828182 21.750511703890215 -9.342416898967652 9.881374370825332 1.0000009639754501 4.748157112747273 0.600543777884851 1.4410325457899977 0.0 0.0 1.3952737420056198 0.46509125426559944 4.545515060457849e-10 9.342416898967652 3.7481561487718227 YGEDGLAGESVEFQNLATLKPSNK(ub)AFEKK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGEDGLAGESVEFQNLATLKPSNKAFEKK 29 3 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 2 69131800.0 9385800.0 38666000.0 21080000.0 True False 14238944.793892013 31765750.201163087 16913528.760307763 1.0 2.2309061985259913 1.1878358266802922 23.76333890061235 -6.605720723853834 2.1696801395199947 1.8247377707302412 1.1914395848742867 0.037222848122621444 0.5312667358350494 0.6245933105800097 5.56536231439617 0.20265473526266636 0.5902019803116536 2.4790156937994273e-07 6.605720723853834 -0.6332981858559545 YGEDGLAGESVEFQNLATLKPSNK(ub)AFEKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGEDGLAGESVEFQNLATLKPSNKAFEKK 29 3 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 2 56170900.0 3643900.0 12055000.0 40472000.0 True False 3030064.3021408194 11990057.322269848 48934508.078614905 1.0 3.9570306523853502 16.149659940893464 21.53091697932449 -6.944177645481453 0.6194785445466893 0.8665067612059933 19.885551454201916 0.9986614895548876 0.2398823068130641 0.08591136492611937 0.04631126275744431 0.24169482025518418 1.0316639973351809 1.1371620415520089e-07 6.944177645481453 19.019044692995923 YGEDGLAGESVEFQNLATLKPSNK(ub)AFEKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGEDGLAGESVEFQNLATLKPSNKAFEKK 29 3 P24928 P24928 POLR2A DNA-directed RNA polymerase II subunit RPB1 2 36031800.0 9385800.0 11980000.0 14666000.0 True False 12150103.121777605 11313302.468733646 11996938.485867811 1.0 0.9311281028105767 0.9873939641190975 23.5344652227048 -10.549567153430692 5.54632731280537 1.0001293486820884 0.959261033464837 0.41141380113341575 0.022970441690680587 3.685652678304128e-05 2.993183737014423e-06 0.022311602362366973 0.007413678176919516 2.8211933181465794e-11 10.549567153430692 -0.040868315217251316 YGEPGEVFINK(ub)GK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGEPGEVFINKGK 13 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 24131150.0 7918950.0 8223300.0 7988900.0 True False 10381820.137220891 6996415.694172342 7162285.26294 1.0 0.6739103164664546 0.6898872421476251 23.30755606289217 -10.316807411750018 8.57856466551937 1.0000004382819037 0.6818987793109904 0.9981115892648619 0.00652255259620604 5.4671340002059577e-08 4.3551228484260195e-09 0.006315443052371664 0.002105144798322332 4.8216156517188035e-11 10.316807411750018 -0.31810165897091325 YGEPGEVFINK(ub)GK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGEPGEVFINKGK 13 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 40118180.0 13335980.0 15770200.0 11012000.0 True False 12912636.61464637 22067323.100506563 8127626.847081271 1.0 1.7089711233317246 0.629432012193573 23.622280276978945 -6.729551687482941 1.7249428861140284 1.4268681221973016 0.6301352787395798 0.5571666975852665 0.2980447231591236 0.3370716575158211 1.9646485112616379 0.13693957209288704 0.3399687206409296 1.8640103201834484e-07 6.729551687482941 -0.7967328434577219 YGEPGEVFINK(ub)GK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGEPGEVFINKGK 13 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 42238400.0 16647500.0 2931900.0 22659000.0 True False 25255474.595273424 2408679.5379607435 18180438.71820748 1.0 0.0953725707618074 0.7198612977801636 24.590092817040404 -10.327995846605795 7.583962414664285 1.0000047440406443 0.407616934545204 0.5454051940133571 0.25494645521919795 2.0450551575100466e-05 1.811574124652145e-06 0.24685281739102666 0.08228361460321407 4.698986024794907e-11 10.327995846605795 -0.5923878094954403 YGEPGEVFINK(ub)GK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGEPGEVFINKGK 13 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 23922950.0 7918950.0 6557200.0 9446800.0 True False 10846799.816577123 6267481.222239298 7215660.402953148 1.0 0.5778184651901411 0.6652340344592219 23.370766124415063 -9.935550207382521 5.591275796706528 1.000000423061399 0.6215262498240315 0.9615293202574633 0.03568725671635446 1.8819757043835893e-07 3.582272109731665e-08 0.03455407634866682 0.011518012577517688 1.1599781070733756e-10 9.935550207382521 -0.37847417323736754 YGEPGEVFINK(ub)GK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGEPGEVFINKGK 13 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 31326880.0 13335980.0 13504400.0 4486500.0 True False 11089458.254085973 13431649.11678649 5424606.4067677865 1.0 1.211208772244354 0.4891678459377454 23.40268555241322 -6.828402064760727 1.3349792379720824 1.1129907869300866 0.47035840084419234 0.9026410498173904 0.09457876464180875 0.18279972373366224 0.6376933564387933 0.05563371013481063 0.12804345687950086 1.48456061700785e-07 6.828402064760727 -0.6426323860858942 down YGEPGEVFINK(ub)GK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGEPGEVFINKGK 13 1 P23246;P23246-2 P23246 SFPQ Splicing factor, proline- and glutamine-rich 1 46085300.0 16647500.0 17136800.0 12301000.0 True False 21550516.921284568 16183122.015542125 10062344.218918584 1.0 0.7509389252542112 0.46691892615255165 24.361219139132853 -6.969412364951855 0.2718545407559559 1.0690367801597602 0.14026133448377534 0.9999774291961221 0.001034654751021577 0.07649383518407801 0.009710459421009869 0.00550491826823105 0.02634863823462193 1.0729701375843515e-07 6.969412364951855 -0.9287754456759849 down YGFTFLGNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGFTFLGNR 9 0 A0A067XG54;Q8NB49-2;Q8NB49-3;Q8NB49-4;Q8NB49 A0A067XG54 ATP11C Phospholipid-transporting ATPase;Phospholipid-transporting ATPase IG 0 3573520.0 723120.0 990900.0 1859500.0 False True 948017.3227040415 843061.5824979482 1667096.7775835153 1.0 0.8892892168818954 1.7585087715785979 19.854553895533854 -6.8749215118018006 1.107677812505186 0.9350670731466652 1.8144243594978582 0.9693555038286051 0.06762617603678125 0.13222630186476458 0.30024981600072254 0.04722357461498694 0.11286775707720816 1.3337624556100766e-07 6.8749215118018006 0.879357286351193 YGFTFLGNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGFTFLGNR 9 0 A0A067XG54;Q8NB49-2;Q8NB49-3;Q8NB49-4;Q8NB49 A0A067XG54 ATP11C Phospholipid-transporting ATPase;Phospholipid-transporting ATPase IG 0 2459250.0 723120.0 793710.0 942420.0 False True 990477.005583221 758641.2677520216 719839.8057491524 1.0 0.7659352650042713 0.7267607442590657 19.917763957056746 -13.999999999999998 0.2515205526409879 2.6403676951556116 0.7112355553584981 0.9995455653123377 0.002571680032227294 14.058872209595991 0.15869673150003288 11.662267968336408 0.01792737418038212 1.0000000000000041e-14 13.999999999999998 -1.9291321397971135 YGGPPPDSVYSGVQPGIGTEVFVGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGGPPPDSVYSGVQPGIGTEVFVGK 25 0 O43390;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 6482450.0 972050.0 3270600.0 2239800.0 False True 1274366.963345589 2782639.228698946 2008046.9816787092 1.0 2.183546269430665 1.5757211536675382 20.281349341397906 -10.139316236813155 5.607326382741127 0.9999868729514564 1.8796337115492043 0.7363181119729441 0.2481435644116588 4.072234264550406e-05 6.2506675086332634e-06 0.2402675534731781 0.08008799103618916 7.255774269955022e-11 10.139316236813155 0.879646838597748 YGGPPPDSVYSGVQPGIGTEVFVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGGPPPDSVYSGVQPGIGTEVFVGK 25 0 O43390;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 6464800.0 0.0 1808900.0 4655900.0 False True 0.0 2531203.203288885 3436380.115993974 0.0 YGGPPPDSVYSGVQPGIGTEVFVGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGGPPPDSVYSGVQPGIGTEVFVGK 25 0 O43390;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 0 5508450.0 972050.0 1944600.0 2591800.0 False True 1331443.153663526 1858681.1420677358 1979670.219796538 1.0 1.3959898602906857 1.4868604899498605 20.344559402920797 -12.1540288272275 0.23840051921073196 5.795695764774361e-10 1.5313056468922241 0.9993857070799748 0.005238808277030456 5.6092525041388 0.14264102377046906 2.784900055011616 0.04473031731427475 7.014087393656452e-13 12.1540288272275 1.5313056463126546 YGGPPPDSVYSGVQPGIGTEVFVGK(ub)IPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGGPPPDSVYSGVQPGIGTEVFVGKIPR 28 1 O43390;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 22035200.0 5377900.0 8367300.0 8290000.0 True False 5207181.508213632 11708406.52489307 6118600.30533088 1.0 2.248511312007201 1.175031117252127 22.312071265362064 -6.60953545188669 2.156721789407482 1.834436361570592 1.1789467176094341 0.04865661767284868 0.5383483552575019 0.6138196742475037 5.410370724959509 0.20624657110535302 0.5972799612901637 2.4573360282649934e-07 6.60953545188669 -0.6554896439611579 YGGPPPDSVYSGVQPGIGTEVFVGK(ub)IPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGGPPPDSVYSGVQPGIGTEVFVGKIPR 28 1 O43390;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 41890700.0 12377000.0 7740700.0 21773000.0 True False 18776813.879903827 6359311.606634849 17469557.006555084 1.0 0.33867894986385305 0.9303791962944334 24.16244894607306 -10.585809743223066 9.251920493898426 1.0000538018872056 0.634529073079162 0.3371669824589214 0.2415606140723309 0.00026811516458467524 1.2003040078983111e-05 0.23392418505009885 0.07796335295014789 2.5953160754564404e-11 10.585809743223066 -0.36552472880804365 YGGPPPDSVYSGVQPGIGTEVFVGK(ub)IPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGGPPPDSVYSGVQPGIGTEVFVGKIPR 28 1 O43390;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 22545100.0 5377900.0 9524600.0 7642600.0 True False 4471962.131365604 9473289.089314919 9240632.324610163 1.0 2.118374174698581 2.066348518427268 22.09247654079634 -10.115801642599015 4.848315835471956 0.9999435723919108 2.0923613465700632 0.9983016563395746 0.021239385257641477 1383031.8900691273 2885637.1005763127 539.7203945964096 0.007270806677494694 7.65946361386694e-11 10.115801642599015 1.0924177741781524 YGGPPPDSVYSGVQPGIGTEVFVGK(ub)IPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGGPPPDSVYSGVQPGIGTEVFVGKIPR 28 1 O43390;O43390-2;O43390-4 O43390;O43390-2 HNRNPR Heterogeneous nuclear ribonucleoprotein R 1 42124000.0 12377000.0 14280000.0 15467000.0 True False 16022270.487144552 13485305.44687115 12652164.704821872 1.0 0.8416600791811041 0.7896611603813155 23.93357526816551 -13.999999999990617 0.15566282359934902 1.7730841007611438 0.736016008099978 0.9995484487740239 0.0019008608160584505 11.983530679340388 0.12451957094511051 2.798559678862979 0.04864033227159463 1.0000000000216045e-14 13.999999999990617 -1.0370680926611657 YGGQPLFSEK(ub)FPTLWSGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGGQPLFSEKFPTLWSGAR 19 1 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 11882200.0 4500600.0 2959100.0 4422500.0 True False 4357730.9165038895 4140684.061502643 3264114.5778438887 1.0 0.9501926899205199 0.7490399568917429 22.05514568422436 -6.944654114892174 0.6147440082643152 1.0022117810962563 0.6864598622224444 0.9987121155302224 0.003893266933510384 0.0857061455693259 0.045412884767606215 0.0039398411730324386 0.016990511673410497 1.1359151322795754e-07 6.944654114892174 -0.31575191887381193 YGGQPLFSEK(ub)FPTLWSGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGGQPLFSEKFPTLWSGAR 19 1 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 1 9525600.0 4500600.0 3041500.0 1983500.0 True False 3742448.310385844 3025114.835809518 2398240.6793321986 1.0 0.8083250815821236 0.6408213234840754 21.835550959658637 -6.972706385991573 0.18229976794817937 1.1256087614230186 0.31899761742378047 0.9999965200066327 0.00027368756740210306 0.07543389764411156 0.005764098269273801 0.00632095936133485 0.018668005773790172 1.064862697962985e-07 6.972706385991573 -0.8066111439992381 YGGSVGSQPPPVAPEPGPVPSSPSQEPPTK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGGSVGSQPPPVAPEPGPVPSSPSQEPPTKR 31 1 Q04323;E9PJ81;E9PRQ7;Q04323-2;A0A087WTZ5;E9PS08 Q04323 UBXN1 UBX domain-containing protein 1 1 38323100.0 9766100.0 14775000.0 13782000.0 True False 12803451.67504694 12570627.592498915 12355970.846279098 1.0 0.9818155222156395 0.9650499849474223 23.61002946218474 -6.972100744136374 0.2018527547108574 1.0097437755864325 0.9366579335519455 0.9999942942473452 3.359917554244405e-05 0.07562720312269713 0.006532469905736831 0.0005361127726348097 0.0017716107963943394 1.0663487295468317e-07 6.972100744136374 -0.07308584203448698 YGGSVGSQPPPVAPEPGPVPSSPSQEPPTK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGGSVGSQPPPVAPEPGPVPSSPSQEPPTKR 31 1 Q04323;E9PJ81;E9PRQ7;Q04323-2;A0A087WTZ5;E9PS08 Q04323 UBXN1 UBX domain-containing protein 1 1 63205000.0 12508000.0 16127000.0 34570000.0 True False 12110940.386533052 22566595.201193962 25515079.922230236 1.0 1.8633231178552607 2.106779416617567 23.529807555529032 -10.67338415548617 0.25956444208652724 2.977226569871207e-13 2.219035870888044 0.9991640801800122 0.01372972378266387 2.394221796386581 0.13132509362431327 1.6172519070097386 0.10547001006173709 2.1213671750340532e-11 10.67338415548617 2.2190358708877467 YGGSVGSQPPPVAPEPGPVPSSPSQEPPTK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGGSVGSQPPPVAPEPGPVPSSPSQEPPTKR 31 1 Q04323;E9PJ81;E9PRQ7;Q04323-2;A0A087WTZ5;E9PS08 Q04323 UBXN1 UBX domain-containing protein 1 1 172788000.0 16184000.0 35434000.0 121170000.0 True False 24552311.208884504 29110525.852894407 97220696.38930225 1.0 1.1856531796632028 3.959737051317676 24.549355501894166 -6.920473004074512 0.8212184430571604 0.9398276847727277 4.411975108395734 0.9943110840190793 0.10209500975820983 0.09789448651894563 0.10418065250525098 0.08818596380409734 0.2653622044273181 1.2009557226013578e-07 6.920473004074512 3.4721474236230065 up YGGSVGSQPPPVAPEPGPVPSSPSQEPPTK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGGSVGSQPPPVAPEPGPVPSSPSQEPPTKR 31 1 Q04323;E9PJ81;E9PRQ7;Q04323-2;A0A087WTZ5;E9PS08 Q04323 UBXN1 UBX domain-containing protein 1 1 40832100.0 9766100.0 9400000.0 21666000.0 True False 13376891.088928945 8984676.918356828 16548937.025276575 1.0 0.6716565798904333 1.2371287854001365 23.673239523707633 -6.749249340252812 1.6523542561785423 0.8067647725057125 1.2382094724366466 0.6458957490344692 0.13796739812711686 0.3013298952809381 1.6184103640667888 0.06596273150953538 0.16028295759236252 1.781355749106926e-07 6.749249340252812 0.43144469993093404 YGGSVGSQPPPVAPEPGPVPSSPSQEPPTK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGGSVGSQPPPVAPEPGPVPSSPSQEPPTKR 31 1 Q04323;E9PJ81;E9PRQ7;Q04323-2;A0A087WTZ5;E9PS08 Q04323 UBXN1 UBX domain-containing protein 1 1 52607000.0 12508000.0 18848000.0 21251000.0 True False 10400956.198352696 18746462.082964912 25694485.846477684 1.0 1.8023787164812768 2.4703965055200574 23.31021283096331 -6.973233038055392 0.1634395891824529 0.3549530900899759 3.935602333195744 0.999997871302724 0.0008770208518443 0.07526687776428405 0.005063001145419345 0.029925186885511545 0.07916896775825566 1.0635721629440719e-07 6.973233038055392 3.580649243105768 YGGSVGSQPPPVAPEPGPVPSSPSQEPPTK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGGSVGSQPPPVAPEPGPVPSSPSQEPPTKR 31 1 Q04323;E9PJ81;E9PRQ7;Q04323-2;A0A087WTZ5;E9PS08 Q04323 UBXN1 UBX domain-containing protein 1 1 153625000.0 16184000.0 34671000.0 102770000.0 True False 20950507.034333635 32741528.371741597 84066914.50924818 1.0 1.562803626570224 4.012643434904919 24.320481823986615 -6.942937032760307 0.6316481491926815 0.9732729329613632 4.73458088418414 0.9985238537748274 0.050248834557789133 0.08645190809272238 0.048697044986591026 0.050079751379036655 0.20827854710366953 1.14041512142991e-07 6.942937032760307 3.7613079512227774 YGGTFQNVSVQLPITLNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGGTFQNVSVQLPITLNK 18 0 O94973;O94973-2;A0A0G2JS82 O94973 AP2A2 AP-2 complex subunit alpha-2 0 4868900.0 1360500.0 2167600.0 1340800.0 False True 1783628.6751007414 1844202.5292386222 1202066.8778617787 1.0 1.033961022820212 0.6739445797449318 20.766383868242638 -6.883792560201659 1.0584496481094035 1.022319492801696 0.6465027446152866 0.9766169278530931 0.024818442870806135 0.12432240623673592 0.25244991717890697 0.01799671286406849 0.04397075453500101 1.3067949267899412e-07 6.883792560201659 -0.37581674818640953 YGGTFQNVSVQLPITLNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGGTFQNVSVQLPITLNK 18 0 O94973;O94973-2;A0A0G2JS82 O94973 AP2A2 AP-2 complex subunit alpha-2 0 12206400.0 5360400.0 3542700.0 3303300.0 False True 5190237.03613461 4957318.584936442 2438066.633124185 1.0 0.9551237352790284 0.469740903190024 22.30736899674104 -6.9249476064222355 0.7871556246457323 1.0089236417317304 0.381807548918306 0.995448696865014 0.01619721469217027 0.09534734654222403 0.09116250333471089 0.014334719965783525 0.04520002558201134 1.1886456177925554e-07 6.9249476064222355 -0.6271160928134245 down YGGTFQNVSVQLPITLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGGTFQNVSVQLPITLNK 18 0 O94973;O94973-2;A0A0G2JS82 O94973 AP2A2 AP-2 complex subunit alpha-2 0 10311600.0 1360500.0 1949800.0 7001300.0 False True 1863513.616130064 1863651.3888736323 5347737.136299678 1.0 1.0000739317074883 2.8697064995989985 20.82959392976553 -6.906901648238553 0.9165798738706179 0.9362887578956088 3.095969135175145 0.9896987748754151 0.0894546730928392 0.10650256937805448 0.15014651889842814 0.07213380040041242 0.19509505972870841 1.2390771602617353e-07 6.906901648238553 2.1596803772795363 up YGGTFQNVSVQLPITLNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGGTFQNVSVQLPITLNK 18 0 O94973;O94973-2;A0A0G2JS82 O94973 AP2A2 AP-2 complex subunit alpha-2 0 10325800.0 5360400.0 2552500.0 2412900.0 False True 4457410.105984149 2538749.175868418 2917426.2340109204 1.0 0.5695570107987381 0.6545115133324229 22.087774272175317 -10.10434669240176 7.3257046393559015 1.000000106537288 0.6120342620655804 0.9652861019730725 0.034682530426584764 6.034399565428919e-08 7.343038854217696e-09 0.0335812249438989 0.011193738562207903 7.86417750602237e-11 10.10434669240176 -0.3879658444717077 YGHAACFGLQPGCLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGHAACFGLQPGCLR 15 0 P52888;K7EP46;K7EL02;K7EMU4 P52888 THOP1 Thimet oligopeptidase 0 61546000.0 17058000.0 18129000.0 26359000.0 False True 22363203.189906973 15424223.866288535 23631623.533382047 1.0 0.6897144266546682 1.056719081461798 24.414623511391643 -6.682632432658857 1.8927153376147423 0.8041420113684355 1.0553459159540195 0.3361332370761744 0.13143173352284437 0.4327009311142321 2.99922907276713 0.05567637251576954 0.14633962609001758 2.076670374409304e-07 6.682632432658857 0.25120390458558395 YGHAACFGLQPGCLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGHAACFGLQPGCLR 15 0 P52888;K7EP46;K7EL02;K7EMU4 P52888 THOP1 Thimet oligopeptidase 0 44001200.0 9653200.0 17373000.0 16975000.0 False True 14644610.143450573 14272652.414131444 13619883.809593206 1.0 0.9746010494184799 0.9300270663527599 23.803866451720594 -6.962520647071422 0.39835984899706856 1.0024950632501097 0.9005099019913038 0.9998524527301677 0.0003512610961178474 0.07881316584454848 0.01789540678211227 0.0005736849538058645 0.003736860444294529 1.0901326644596912e-07 6.962520647071422 -0.10198516125880597 YGHAACFGLQPGCLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGHAACFGLQPGCLR 15 0 P52888;K7EP46;K7EL02;K7EMU4 P52888 THOP1 Thimet oligopeptidase 0 56168000.0 17058000.0 17261000.0 21849000.0 False True 23364803.57511696 16498351.94550611 16688716.194279883 1.0 0.7061198649697411 0.7142673440684529 24.477833572914534 -10.55902310600318 6.29752716642388 1.0004842214184686 0.7101936045190971 0.9994075717131715 0.0033261944136391596 2.2649940201132582e-05 1.5860313808247696e-06 0.003225795645965932 0.001073524630856046 2.760430987617146e-11 10.55902310600318 -0.2902906168993715 YGHAACFGLQPGCLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGHAACFGLQPGCLR 15 0 P52888;K7EP46;K7EL02;K7EMU4 P52888 THOP1 Thimet oligopeptidase 0 52862200.0 9653200.0 21143000.0 22066000.0 False True 12496257.693019623 19966373.46380929 18050214.41627975 1.0 1.597788230228515 1.4444495992078137 23.574992773813044 -10.072772553155557 4.6790109562424185 0.9999779141293546 1.5211189146553463 0.9390228769045799 0.06260023402764303 43457703.11730505 0.09042325361707348 11190.880029603559 0.021429725168482544 8.457216469147549e-11 10.072772553155557 0.5211410005259918 YGINTTDIFQTVDLWEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGINTTDIFQTVDLWEGK 18 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 159309000.0 17815000.0 118570000.0 22924000.0 False True 27026657.450956345 97410257.1083615 18393061.35205387 1.0 3.6042287983679095 0.6805525761160311 24.687879760356545 -6.671736465166385 1.9310563725198742 2.659732732522655 0.6922118674378858 0.2868993824931224 1.10576890109227 0.45709729281275124 3.28772081262227 0.4607069011041755 1.2281851059177484 2.1294308168636875e-07 6.671736465166385 -1.967520865084769 YGINTTDIFQTVDLWEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGINTTDIFQTVDLWEGK 18 0 P37802;P37802-2;X6RJP6 P37802 TAGLN2 Transgelin-2 0 17815000.0 17815000.0 0.0 0.0 False True 23061868.68615013 0.0 0.0 1.0 0.0 0.0 24.459006082448994 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 YGISGELAMRPLASLSGGQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGISGELAMRPLASLSGGQK 20 1 Q9NUQ8;Q9NUQ8-2 Q9NUQ8 ABCF3 ATP-binding cassette sub-family F member 3 0 23035700.0 5086600.0 10164000.0 7785100.0 False True 7716744.080271372 8350154.788305534 6246371.572669447 1.0 1.08208263763127 0.8094568781461758 22.879560830020825 -6.825968519836593 1.3457940821561603 1.0439963718796463 0.8027050748972389 0.8975740838498965 0.0365477339860723 0.18583959857968982 0.6596685547694093 0.021330750590387686 0.049105081289519605 1.492902619830617e-07 6.825968519836593 -0.24129129698240748 YGISSMIQSQEKPDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGISSMIQSQEKPDR 15 1 P14868;H7C278 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 30791700.0 7749400.0 8818300.0 14224000.0 False True 10159538.44529636 7502644.0134641705 12752236.9262425 1.0 0.7384827621709259 1.2551984516724284 23.276331525198824 -6.769107463445202 1.577786064401828 0.8498285887848287 1.258012359139401 0.7271502599278261 0.11019163298785566 0.2678834715973166 1.3159462277361629 0.055052527442516416 0.131159944402892 1.7017373720556706e-07 6.769107463445202 0.4081837703545723 YGISSMIQSQEKPDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGISSMIQSQEKPDR 15 1 P14868;H7C278 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 18664100.0 5401600.0 1664500.0 11598000.0 False True 5230129.16468635 2329143.53025283 8560135.867458088 1.0 0.4453319329050468 1.636696838245569 22.318415145423813 -6.780104336482273 1.53546655507354 0.6859773138934686 1.6461658228630762 0.7677638121420969 0.23457244635823257 0.2504091361731133 1.166120787473642 0.12032398955456641 0.28388903949656324 1.659188250146068e-07 6.780104336482273 0.9601885089696076 YGISSMIQSQEKPDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGISSMIQSQEKPDR 15 1 P14868;H7C278 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 26414400.0 7749400.0 7362000.0 11303000.0 False True 10614562.599660663 7036722.49712159 8633464.192592124 1.0 0.6629309904250362 0.813360335061581 23.339541586721715 -10.163512871513708 4.956959173500869 1.00001869076645 0.7381456627427263 0.8015916171345651 0.06141252278548504 1.2686209561784533e-05 2.140753742930359e-06 0.05946666117842177 0.019820806499442494 6.862575389768561e-11 10.163512871513708 -0.2618730280237236 YGISSMIQSQEKPDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGISSMIQSQEKPDR 15 1 P14868;H7C278 P14868 DARS Aspartate--tRNA ligase, cytoplasmic 0 14687400.0 5401600.0 6136100.0 3149700.0 False True 4491669.731453619 6103043.611379512 3808287.7074326323 1.0 1.3587471867403775 0.8478556828799105 22.09882042085809 -6.71800953814553 1.7668572986966624 1.2187243355253277 0.8487598381049646 0.5029536876835996 0.15100012160147758 0.3591897793559473 2.1903975848938466 0.0678929073194988 0.1708124419177306 1.914213883844286e-07 6.71800953814553 -0.3699644974203631 YGIVDYMIEQSGPPSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGIVDYMIEQSGPPSK 16 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 32822900.0 5505700.0 9605200.0 17712000.0 False True 7218026.017274642 8172141.600776345 15879332.145501072 1.0 1.1321851128297753 2.1999549610236424 22.783172912742952 -6.929915811246375 0.747482523569178 0.9837122269703946 2.418693809147149 0.9965217315226547 0.031683841912179406 0.09268130824168838 0.07789418750411758 0.02885119234587455 0.0966592911476886 1.1751253329859342e-07 6.929915811246375 1.4349815821767544 up YGIVDYMIEQSGPPSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGIVDYMIEQSGPPSK 16 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 24903500.0 7903700.0 3974800.0 13025000.0 False True 7652801.369766656 5561958.3683081735 9613361.758375723 1.0 0.7267872377142025 1.2561885894954108 22.86755652398748 -6.766401032616053 1.5879677396084966 0.8425792073496041 1.2587899885573677 0.7167435457802074 0.11504669981092679 0.27226698357196544 1.3543287704153444 0.05712271062247703 0.1364441141369577 1.7123753497486257e-07 6.766401032616053 0.41621078120776356 YGIVDYMIEQSGPPSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGIVDYMIEQSGPPSK 16 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 27659700.0 5505700.0 12000000.0 10154000.0 False True 7541306.075948029 11469800.32130661 7755834.328194328 1.0 1.5209302216081615 1.0284470952492577 22.846382974265843 -10.620783247632906 3.040063773035345 0.9807159109423453 1.2746886582817338 0.2931856968997163 0.2010553966234675 74165816.01654638 75723002.97054337 11295281.623982346 0.0735787171655945 2.3945105363345482e-11 10.620783247632906 0.2939727473393885 YGIVDYMIEQSGPPSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGIVDYMIEQSGPPSK 16 0 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 14305600.0 7903700.0 2446700.0 3955200.0 False True 6572276.743277922 2433519.141468075 4782214.033221428 1.0 0.3702703395679528 0.7276343069565113 22.647961799421758 -10.69678372292722 6.940115632689451 1.0035470427732365 0.5489523232623423 0.6799013767842783 0.1458932287597627 0.008044105928851825 0.00035144950481650944 0.14191503659389182 0.04708683710924916 2.0100935826930704e-11 10.69678372292722 -0.45459471951089414 YGK(ub)AGEVFIHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGKAGEVFIHK 11 1 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 77541180.0 21360580.0 32721600.0 23459000.0 True False 28003927.236151 27839664.827797834 21031687.714617748 1.0 0.9941343081287144 0.7510263663114863 24.73912582733957 -6.912089918607281 0.881366579632863 1.0070387695001048 0.7181610006304842 0.9916869649197969 0.010577258984161187 0.10305260066734445 0.13138528772634406 0.008750231884361068 0.024519602934634753 1.224362674550848e-07 6.912089918607281 -0.2888777688696207 YGK(ub)AGEVFIHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGKAGEVFIHK 11 1 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 114992780.0 34072370.0 29549310.0 51371100.0 True False 32990761.264622364 41348503.58061593 37915467.81003417 1.0 1.2533358429942019 1.1492753230490869 24.975558732809258 -10.166730937252007 4.976366193415064 0.99998563838851 1.2013055830220356 0.8330479952169976 0.04248252937373022 6.769560292023751e-06 1.133445813632093e-06 0.041136465398717056 0.013711177397241479 6.811912531322212e-11 10.166730937252007 0.20131994463352565 YGK(ub)AGEVFIHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGKAGEVFIHK 11 1 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 234008300.0 39335000.0 54908000.0 139765300.0 True False 59674070.77369452 45109238.40183791 112140627.19369294 1.0 0.7559269514712398 1.879218657948951 25.83060086048934 -6.849803309660428 1.2360123994622914 0.8697710751719033 1.923958517363845 0.9400169072489442 0.11814655261424996 0.15767935582444087 0.46365024083685613 0.07479915912051184 0.17307096000701216 1.4131774224591872e-07 6.849803309660428 1.0541874421919415 YGK(ub)AGEVFIHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGKAGEVFIHK 11 1 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 77314450.0 21360580.0 25486000.0 30467870.0 True False 29258163.673969544 24359944.249068353 23271986.611479435 1.0 0.8325862320177309 0.7954014773724196 24.802335888862462 -13.99999999708641 0.21142302272447802 1.9739212315104877 0.7737994414251793 0.9994908544115032 0.002007951626018328 12.780321971115576 0.14572895173417344 5.174049146037991 0.021808771867784727 1.0000000067087874e-14 13.99999999708641 -1.2001217900853085 YGK(ub)AGEVFIHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGKAGEVFIHK 11 1 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 114162270.0 34072370.0 53513500.0 26576400.0 True False 28332685.31692244 53225212.15390189 32133402.364610154 1.0 1.8785798648641232 1.1341460227004192 24.755964008243534 -10.238599712734139 4.524296664197369 0.9998194191539065 1.5063629437854567 0.381530161876387 0.3039138434430276 35033968.518126585 79282961.01229952 41088.12695236556 0.10403778964792121 5.772983115044369e-11 10.238599712734139 0.5065435246315502 YGK(ub)AGEVFIHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGKAGEVFIHK 11 1 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 1 282223900.0 39335000.0 54174000.0 188714900.0 True False 50919932.90876876 51159169.27722675 154370724.57839182 1.0 1.0046982852252895 3.031636448833736 25.60172718258179 -6.907406301666231 0.9132162364615115 0.9319787511986808 3.2795560852812096 0.9899054260717879 0.09611300383625505 0.10615823941414602 0.14825570510009953 0.07769350365245249 0.21080409127407068 1.2376381795734326e-07 6.907406301666231 2.347577334082529 up YGK(ub)AGEVFIHKDK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGKAGEVFIHKDK 13 2 Q15233;Q15233-2;H7C367;C9JYS8;C9IZL7 Q15233 NONO Non-POU domain-containing octamer-binding protein 2 4533300.0 1104100.0 1415700.0 2013500.0 True False 1069050.9498537842 1980996.3927779694 1486103.9462947804 1.0 1.8530420772264535 1.3901151731805086 20.02789918136272 -10.199438239177582 4.7642061692971005 0.9999046205548359 1.6215786252059339 0.7062143867942258 0.18898911719491734 0.00019149159600616026 3.217776565276836e-05 0.18301580157002342 0.06099597529133296 6.317740171975356e-11 10.199438239177582 0.621674004651098 YGK(ub)DATNVGDEGGFAPNILENK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGKDATNVGDEGGFAPNILENK 22 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 518145000.0 60540000.0 50785000.0 406820000.0 True False 78370223.42180923 47958770.10639711 332782934.325702 1.0 0.6119514276266682 4.2462930408476245 26.22380227414321 -6.880483513920694 1.0770588799376482 0.7579002049213124 4.506298121730553 0.9740750669688971 0.26236944046890937 0.12720446932343887 0.2696834065431677 0.18756146075333155 0.4541490717704264 1.316789897908072e-07 6.880483513920694 3.7483979168092407 up YGK(ub)DFNDIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGKDFNDIR 9 1 O94776;O94776-2;E9PCS8;F6RRE2;E7EV10;Q9BTC8;E7EQY4;Q9BTC8-2 O94776;E7EQY4 MTA2;MTA3 Metastasis-associated protein MTA2;Metastasis-associated protein MTA3 1 11370300.0 3463200.0 1726100.0 6181000.0 True False 4483180.669877923 1630041.0176361564 5056121.422415717 1.0 0.3635903028821148 1.1277978280882877 22.096091209753325 -6.6856616830274165 1.8815726945780358 0.5994073584188063 1.1250458730556572 0.350310524698337 0.269397183810908 0.42606446645294915 2.9209357294762976 0.11467985352524208 0.30030623754235497 2.0622357768328918e-07 6.6856616830274165 0.5256385146368509 YGK(ub)EGLNGGGGGGSHFDSPFEFGFTFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGKEGLNGGGGGGSHFDSPFEFGFTFR 27 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;O75190-4;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 34128700.0 15365000.0 4920700.0 13843000.0 True False 14877246.48537577 6885561.171111508 10217103.018901726 1.0 0.4628249708627176 0.6867603510464835 23.826604198084315 -10.272815429757996 5.642159089715784 1.000033551328324 0.5747926609545948 0.8278008319593935 0.0914212361344237 3.858666603142682e-05 4.973286183815491e-06 0.08852519874258157 0.029506077086522763 5.335616049561058e-11 10.272815429757996 -0.42524089037372925 YGK(ub)EGLNGGGGGGSHFDSPFEFGFTFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGKEGLNGGGGGGSHFDSPFEFGFTFR 27 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;O75190-4;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 104141400.0 26458000.0 44883400.0 32800000.0 True False 40138720.338894375 36873606.594395176 26317065.623249274 1.0 0.9186542640888502 0.6556528310083685 25.258491287136295 -6.9497569658586515 0.5615036161959013 1.0034130163573272 0.5582922947475467 0.9991820844422176 0.004202793853461135 0.083583439728909 0.036367109624790755 0.004497017657080574 0.02186976728652222 1.1226465191668618e-07 6.9497569658586515 -0.44512072160978045 YGK(ub)EGLNGGGGGGSHFDSPFEFGFTFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGKEGLNGGGGGGSHFDSPFEFGFTFR 27 1 O75190;A0A0J9YX62;O75190-3;E9PH18;C9J2C4;C9JDX6;F8WCZ4;C9J2P2;C9JDR7;O75190-4;O75190-2 O75190;O75190-2 DNAJB6 DnaJ homolog subfamily B member 6 1 93668900.0 26458000.0 29669900.0 37541000.0 True False 34250402.56515074 28018743.983061757 30708923.203188535 1.0 0.8180559025478551 0.8966003580475984 25.029617609228744 -10.118452187770078 4.46726468723851 1.0000152703922007 0.8573281302920871 0.8147910777945401 0.03206563971047346 5.254860576786615e-06 1.0369549425613347e-06 0.031051001520244783 0.010349140711443874 7.612859456775942e-11 10.118452187770078 -0.14268714010011363 YGK(ub)IETIEVMEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGKIETIEVMEDR 13 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 36750000.0 12276000.0 10541000.0 13933000.0 True False 11886305.099542655 14750076.2705888 10283529.318959622 1.0 1.2409303098871602 0.865157778875733 23.502796982070475 -6.733508909822912 1.7101679577535305 1.1444157537724395 0.8652216458769056 0.57561808976818 0.10125622613582744 0.3296761849940328 1.8904309469822456 0.04688796121757816 0.11590186938542368 1.8471029000496818e-07 6.733508909822912 -0.2791941078955339 YGK(ub)IETIEVMEDR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 YGKIETIEVMEDR 13 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 35395100.0 14143500.0 15070200.0 6181400.0 True False 11760946.913287602 14989013.841399502 7473902.16043561 1.0 1.2744733865318962 0.6354847288691986 23.48750088527933 -6.789996528002793 1.4965395660836665 1.1534038199805685 0.6287073593352379 0.8012554485541921 0.11668033454588884 0.23535661202043617 1.0413588783646943 0.06137144874072886 0.14367403208180882 1.621823063083505e-07 6.789996528002793 -0.5246964606453306 YGK(ub)IETIEVMEDR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 YGKIETIEVMEDR 13 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 102949700.0 17330000.0 39396700.0 46223000.0 True False 22434026.625370894 37204239.01251737 37810888.2880314 1.0 1.658384365579859 1.6854258452769526 24.419185253475867 -11.312035130739707 0.5297893249740246 1.9241048228595977e-20 1.6834909710944266 0.9998793736156306 0.0034808545264314876 3.6745048098835595 0.26013254558037724 4.303239012184248 0.005218792791875659 4.874890547789837e-12 11.312035130739707 1.6834909710944266 YGK(ub)IVGCSVHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGKIVGCSVHK 11 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;G3V4M8;G3V2H6;B3KT61;Q86SE5;Q86SE5-3;E5RG71;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;RALYL Heterogeneous nuclear ribonucleoproteins C1/C2;RNA-binding Raly-like protein 1 54780000.0 17405000.0 20562000.0 16813000.0 True False 22818123.55025976 17494229.750048235 15073352.041684115 1.0 0.7666813492141461 0.6605868360947025 24.443676820604004 -13.999999999999671 0.10613124891524003 2.134367301140079 0.45465436451657615 0.99976272912183 0.002183798932571602 12.036832817814501 0.09820281497710663 2.948335736148168 0.1831323373597854 1.0000000000007567e-14 13.999999999999671 -1.679712936623503 YGK(ub)IVGCSVHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGKIVGCSVHK 11 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;G3V4M8;G3V2H6;B3KT61;Q86SE5;Q86SE5-3;E5RG71;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;RALYL Heterogeneous nuclear ribonucleoproteins C1/C2;RNA-binding Raly-like protein 1 128001000.0 24707000.0 25825000.0 77469000.0 True False 37482325.32364746 21216326.97835403 62157218.1941311 1.0 0.566035505939348 1.658307419761824 25.159707121713232 -6.7988986035167045 1.4603652908033513 0.7602250915661265 1.6729847395048867 0.8289285807454323 0.18572744709850675 0.2223373054410082 0.9362356397742314 0.10005544911036693 0.23285410510836924 1.588917676309785e-07 6.7988986035167045 0.9127596479387602 YGK(ub)IVGCSVHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGKIVGCSVHK 11 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;G3V4M8;G3V2H6;B3KT61;Q86SE5;Q86SE5-3;E5RG71;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;RALYL Heterogeneous nuclear ribonucleoproteins C1/C2;RNA-binding Raly-like protein 1 56381000.0 17405000.0 17689000.0 21287000.0 True False 23840098.85243937 16907441.490299374 16259449.01952656 1.0 0.7092018197973776 0.6820210402719391 24.506886882126896 -13.999999999999998 0.33529516760548705 4.268497710674607 0.67750070764892 0.9997257234380941 0.0023834712198876518 19.28036334746746 0.1854600240227382 44.56036183188074 0.008541566190292858 1.0000000000000041e-14 13.999999999999998 -3.590997003025687 YGK(ub)IVGCSVHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGKIVGCSVHK 11 1 B2R5W2;P07910-2;G3V4W0;B4DY08;G3V4C1;P07910-4;G3V3K6;G3V5X6;G3V251;B4DSU6;G3V4M8;G3V2H6;B3KT61;Q86SE5;Q86SE5-3;E5RG71;P07910;G3V2Q1;G3V576;G3V555;G3V575 B2R5W2;P07910 HNRNPC;RALYL Heterogeneous nuclear ribonucleoproteins C1/C2;RNA-binding Raly-like protein 1 110834000.0 24707000.0 35058000.0 51069000.0 True False 31983698.54778065 33106991.481541254 41774966.01219028 1.0 1.0351207954290373 1.3061330586824533 24.930833443805682 -6.930772470838108 0.740414461822182 0.9959948062368328 1.3628828309135212 0.9966881179092435 0.0078720031210081 0.09223831026175315 0.07572692810979602 0.007205066433675505 0.024418514764075926 1.1728096457599267e-07 6.930772470838108 0.36688802467668846 YGK(ub)SPYLYPLYGLGELPQGFAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGKSPYLYPLYGLGELPQGFAR 22 1 P31150;P50395;P50395-2;Q5SX91;Q5SX87 P31150;P50395 GDI1;GDI2 Rab GDP dissociation inhibitor alpha;Rab GDP dissociation inhibitor beta 1 77020300.0 6590300.0 10204000.0 60226000.0 True False 9997966.915466623 8383016.475784103 48322304.702006474 1.0 0.8384721160474907 4.833213103281327 23.25320332229368 -6.897477622239083 0.9770929623911815 0.8222241426570464 5.2316720174178695 0.9852685526727147 0.2240845572134654 0.11328528748497382 0.18808333837619842 0.17279061102810161 0.44413585755956997 1.2662585119508394e-07 6.897477622239083 4.409447874760823 up YGLECLFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGLECLFR 8 0 Q6PKG0-3;Q6PKG0;Q659C4-7;Q659C4-6;Q659C4-5;A0A3B3ISF0;Q659C4-2;Q659C4 Q6PKG0-3;A0A3B3ISF0 LARP1;LARP1B La-related protein 1;La-related protein 1B 0 6412600.0 2263200.0 1519600.0 2629800.0 False True 2967077.11685998 1292881.6033544058 2357693.5228228695 1.0 0.43574250093056094 0.7946182151537694 21.50061099350185 -10.124360766901535 5.311566415487844 1.0000085949091129 0.6151803580419487 0.6052238126351859 0.14651039682144024 1.4912236544298669e-05 2.45837752912919e-06 0.1418612488322421 0.047286027244521814 7.509987827780984e-11 10.124360766901535 -0.38482823686716416 YGLIFHSTFIGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGLIFHSTFIGR 12 0 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 0 50000700.0 19962500.0 22767500.0 7270700.0 False True 26171030.81712497 19370677.7470199 6518397.709479146 1.0 0.7401572327194972 0.2490692000260778 24.641467414178916 -7.059391754771133 0.4451087943081397 1.017409449774772 5.846921298047247e-12 0.99974865118794 0.004936511889746171 0.07384566334998076 0.0222883575069448 0.006789730298901805 0.03780193045574913 8.721842607615822e-08 7.059391754771133 -1.0174094497689252 down YGLIFHSTFIGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGLIFHSTFIGR 12 0 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 0 64084400.0 25922300.0 16231100.0 21931000.0 False True 25099410.775649633 22712262.874068294 16186613.18410272 1.0 0.9048922732521973 0.6449001264924623 24.581150160617618 -6.953519981832134 0.518763020497039 1.0044605552099628 0.5337537711042417 0.9994493511398178 0.003521943470160687 0.08210233576677442 0.030345359937738035 0.003997813299491506 0.021472928297083752 1.1129611844256779e-07 6.953519981832134 -0.4707067841057211 YGLIFHSTFIGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGLIFHSTFIGR 12 0 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 0 316086000.0 73139000.0 71792000.0 171155000.0 False True 110957210.17712574 58980156.68654379 137326139.23009846 1.0 0.5315576751829939 1.2376495318409582 26.725428178312992 -6.7277995617965605 1.7309491977739895 0.7174147264955132 1.2370893137467407 0.549205522071724 0.19695793624190736 0.3403604475974179 1.9967587102381552 0.09020332984374038 0.22441920686002464 1.8715457081115945e-07 6.7277995617965605 0.5196745872512275 YGLIFHSTFIGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGLIFHSTFIGR 12 0 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 0 67498600.0 19962500.0 18992000.0 28544100.0 False True 27343175.716278113 18152870.641854588 21802571.464192607 1.0 0.6638903553199091 0.797367931597388 24.704677475701807 -10.067734342588084 4.902613206129472 1.000007241235672 0.7306291439387103 0.8444861088431425 0.05449199233855708 4.313098259438219e-06 8.201529957935171e-07 0.05276306269087615 0.017587214901264473 8.55589916168996e-11 10.067734342588084 -0.2693780972969617 YGLIFHSTFIGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGLIFHSTFIGR 12 0 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 0 65762100.0 25922300.0 15726800.0 24113000.0 False True 21555541.002602972 15642076.606874617 29154916.814084817 1.0 0.7256638376640946 1.3525486004069287 24.361555436051894 -6.787749457170301 1.5051921982581309 0.8462211259814737 1.3588191915979673 0.7939723579757256 0.1164658562370472 0.23873142341008455 1.0685199337427056 0.060910389249598657 0.14285081104260505 1.6302362384794007e-07 6.787749457170301 0.5125980656164936 YGLIFHSTFIGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGLIFHSTFIGR 12 0 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 0 271454000.0 73139000.0 102248000.0 96067000.0 False True 94679877.2852278 96557808.91678447 78583791.73066016 1.0 1.0198345380814056 0.8299946512807849 26.49655450040544 -6.881102349728827 1.0736816200789459 1.0124801961231038 0.8162558313057274 0.974561699794469 0.013589195241791882 0.126655825396384 0.26645036196118244 0.009740170292470126 0.023620600479609247 1.3149149110448745e-07 6.881102349728827 -0.19622436481737637 YGLIGLNGIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGLIGLNGIGK 11 0 Q9UG63;Q9UG63-2;C9JHK9;C9JZV3 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 0 13007600.0 6269200.0 0.0 6738400.0 False True 8587092.658759713 0.0 5146928.701704217 1.0 0.0 0.5993796627376349 23.03373832853869 -10.08614298067403 6.6172272862330335 1.000000628189725 0.29968983136881644 0.645413366600938 0.2446957226514507 2.268032588557421e-06 3.1318068209144143e-07 0.23692583001573195 0.07897520489310413 8.200815084080693e-11 10.08614298067403 -0.7003107968209085 YGLIYHASLVGQTSPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGLIYHASLVGQTSPK 16 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 55896000.0 18614000.0 16984000.0 20298000.0 False True 24403134.258232404 14450053.403113479 18197757.672164664 1.0 0.5921392412222111 0.7457139513144975 24.540563118901957 -10.102567880440729 4.890547563714901 1.0000133806316776 0.6689265962670818 0.861043964524003 0.06269661286076071 9.243004516731711e-06 1.69609346697283e-06 0.06070821245439589 0.02023524478843217 7.896454177874668e-11 10.102567880440729 -0.3310867843645957 YGLIYHASLVGQTSPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGLIYHASLVGQTSPK 16 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 43979000.0 13971000.0 6768000.0 23240000.0 False True 13527498.252338765 9470497.694653744 17152746.814944495 1.0 0.700092324389426 1.2679910575467241 23.689391719145476 -6.763209881469184 1.6002259518686082 0.8264926576312928 1.2704128886268409 0.7039777760223124 0.12620772501001234 0.27756619050821224 1.4015082167496036 0.06220512239549299 0.14902846593941887 1.7250040479139474e-07 6.763209881469184 0.4439202309955481 YGLIYHASLVGQTSPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGLIYHASLVGQTSPK 16 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 69316000.0 15665000.0 20582000.0 33069000.0 False True 23764950.264902145 16908981.292100035 26532897.655342404 1.0 0.711509222767972 1.116471836026864 24.5023320465943 -6.71535574642981 1.7756035530950698 0.8236308762996837 1.1157020365360961 0.49078416679512693 0.1214710939885711 0.36438111256203937 2.242428072677968 0.05436942782580734 0.13726065767903148 1.9259466538153187e-07 6.71535574642981 0.29207116023641244 YGLIYHASLVGQTSPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGLIYHASLVGQTSPK 16 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 54520000.0 18614000.0 16030000.0 19876000.0 False True 25496098.824435864 15321741.595878737 15181698.159069382 1.0 0.6009445484732017 0.5954518086711761 24.60377318042485 YGLIYHASLVGQTSPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGLIYHASLVGQTSPK 16 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 30232200.0 13971000.0 6692000.0 9569200.0 False True 11617505.520241886 6655948.867741996 11570075.477018243 1.0 0.5729240977028099 0.9959173642619749 23.469796994579752 -10.941356329288814 10.507477696537276 1.0521686901912282 0.7844207309823925 0.25723816302588565 0.17268627795050417 0.10129077878360283 0.0005653170370623496 0.08025004672150599 0.055734256551737346 1.1445734581613594e-11 10.941356329288814 -0.26774795920883565 YGLIYHASLVGQTSPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGLIYHASLVGQTSPK 16 0 Q9Y2X3 Q9Y2X3 NOP58 Nucleolar protein 58 0 70866000.0 15665000.0 29726000.0 25475000.0 False True 20278651.30331419 28071721.96874589 20838811.395573616 1.0 1.3842992588051484 1.0276231433679162 24.27345836868675 -10.717535800033206 7.684092050274607 0.9986090742231952 1.2059612010864267 0.3077629574222288 0.14561241437654152 0.0034910675168554578 0.0001283302622213282 0.14185508372781197 0.0469962046567832 1.9163030903346427e-11 10.717535800033206 0.20735212686323146 YGLK(ub)HLTEEKPDGLINEATR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGLKHLTEEKPDGLINEATR 20 2 Q9BRT8;Q9BRT8-3;Q9BRT8-2;A0A087X140;F2Z2T4 Q9BRT8 CBWD1 COBW domain-containing protein 1 1 12324900.0 1373700.0 1977500.0 8973700.0 True False 1330092.6454253646 2767126.0625262656 6623218.764770533 1.0 2.0804009946550277 4.979516868655734 20.343095307111334 -6.953927764485996 0.5139195599897676 0.9483176294634237 6.239641487614272 0.9994745534210284 0.03851538057015182 0.0819458764046681 0.029724119696888276 0.044067843490704535 0.23933923139579108 1.1119166552396927e-07 6.953927764485996 5.291323858150848 YGLK(ub)HLTEEKPDGLINEATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGLKHLTEEKPDGLINEATR 20 2 Q9BRT8;Q9BRT8-3;Q9BRT8-2;A0A087X140;F2Z2T4 Q9BRT8 CBWD1 COBW domain-containing protein 1 1 9095200.0 1373700.0 1681500.0 6040000.0 True False 1142292.4152284223 1672441.4257483834 7302936.074195345 1.0 1.4641097178378342 6.393228193443786 20.12350058254561 -6.925231600584261 0.7849392703202781 0.9103412372476016 7.2923507632956825 0.9955153179873362 0.1634259279543631 0.09519037358410531 0.09036973190486128 0.1448627665067817 0.4582480828462184 1.1878685918739815e-07 6.925231600584261 6.382009526048081 up YGLK(ub)HLTEEKPDGLINEATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGLKHLTEEKPDGLINEATR 20 2 Q9BRT8;Q9BRT8-3;Q9BRT8-2;A0A087X140;F2Z2T4 Q9BRT8 CBWD1 COBW domain-containing protein 1 1 83744400.0 5440400.0 11880000.0 66424000.0 True False 7042705.046316651 11218867.556640688 54335513.567795165 1.0 1.5929770568069124 7.715148257729855 22.747698232183918 -6.925680152440897 0.7814381370054553 0.890502627049453 8.844065750467632 0.9956189760809563 0.20091457344968758 0.09494360289674668 0.08912961371055116 0.1785402444294849 0.5676752528640135 1.1866423603123252e-07 6.925680152440897 7.953563123418179 up YGLLVGGAASHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGLLVGGAASHR 12 0 Q15274 Q15274 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] 0 31460300.0 10262000.0 5836300.0 15362000.0 False True 13453581.37734935 4965546.789719213 13772487.602709306 1.0 0.369087356774701 1.0237041882317575 23.681486937184374 -10.942260238679278 12.840680815492336 1.0550668163856718 0.6963957725032294 0.2228788104133984 0.26724620235121405 0.13650389162309326 0.0006138061082160678 0.08383986999620997 0.08625334092028579 1.1421937024308453e-11 10.942260238679278 -0.3586710438824424 YGLLVGGAASHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGLLVGGAASHR 12 0 Q15274 Q15274 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] 0 21392500.0 8675800.0 2307700.0 10409000.0 False True 8400391.477892818 3229176.644496516 7682570.636693496 1.0 0.3844078758703914 0.9145491203489267 23.002025131745842 -10.328124505459128 8.292035893665998 1.0000009408035488 0.6494784981096704 0.36824323582337304 0.21642925676274688 3.764193449129264e-06 3.050337485363035e-07 0.20955728877648855 0.06985224225618064 4.6975941659593386e-11 10.328124505459128 -0.35052244269387844 YGLLVGGAASHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGLLVGGAASHR 12 0 Q15274 Q15274 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] 0 15225100.0 10262000.0 4963100.0 0.0 False True 14056138.72012253 4743813.831223065 0.0 1.0 0.337490538879778 0.0 23.744696998707266 -8.557846364283284 0.5069980047813638 1.0564293229435215 5.02324249040039e-18 0.9938511639303624 0.03257133543129213 0.24781285727752558 0.18599166419281826 0.08679427577524944 0.06544257067540757 2.7679206499375134e-09 8.557846364283284 -1.0564293229435215 YGLLVGGAASHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGLLVGGAASHR 12 0 Q15274 Q15274 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] 0 14531400.0 8675800.0 2912400.0 2943200.0 False True 7214312.103107471 2896710.3231338626 3558609.512180752 1.0 0.40152273449413733 0.4932708013350195 22.78243040718012 -10.779729538562577 7.140345239405853 1.0147776807488293 0.4473967679145784 0.9797445848556816 0.03745599144115438 0.00854268579462367 0.00026353049074599266 0.03516031112828044 0.01208886925560654 1.6606207544528612e-11 10.779729538562577 -0.567380912834251 YGLLVGGAASHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGLLVGGAASHR 12 0 Q15274 Q15274 QPRT Nicotinate-nucleotide pyrophosphorylase [carboxylating] 0 14038900.0 3167900.0 6637000.0 4234000.0 False True 4100908.998644687 6267645.115608115 3463455.4445086834 1.0 1.528355083636217 0.8445579859619718 21.967512299172995 -6.700388716016322 1.8296620767871983 1.3279620193465806 0.8465871492589035 0.4193835217730254 0.22300899784050982 0.39469104343248945 2.569096604368923 0.09723186617698201 0.2499181974871473 1.9934772510141986e-07 6.700388716016322 -0.4813748700876771 YGLNMCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGLNMCR 7 0 A0A2R8Y851;P62273;P62273-2;A0A2R8Y6P7;A0A087WTT6 A0A2R8Y851 RPS29 40S ribosomal protein S29 0 15613700.0 2975400.0 7625200.0 5013100.0 False True 3900778.213814589 6487549.882796795 4494392.501050772 1.0 1.6631424621428528 1.1521784256110488 21.895330542840224 -10.38329750879649 4.7284319261615595 0.999505390077962 1.4076604438772118 0.45907993176309025 0.20860019440352018 0.001088955464462664 0.00014202634737239215 0.20221537857518723 0.06732542324491153 4.137161658825528e-11 10.38329750879649 0.40815505379924977 YGLNMCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGLNMCR 7 0 A0A2R8Y851;P62273;P62273-2;A0A2R8Y6P7;A0A087WTT6 A0A2R8Y851 RPS29 40S ribosomal protein S29 0 10998500.0 2975400.0 3393300.0 4629800.0 False True 4075485.7871616283 3243372.785857471 3536336.593724062 1.0 0.7958248305207115 0.8677092200551982 21.958540604363115 -10.624589416136322 9.05630848944057 1.0000670003489893 0.8317670264187369 0.8795592844897939 0.029346679138492624 3.971562524744124e-05 1.6463268925881193e-06 0.02842606106802993 0.009471599964156224 2.3736166726100024e-11 10.624589416136322 -0.16829997393025242 YGLPVNFQAMLLQPNKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGLPVNFQAMLLQPNKK 17 1 E7EV59;P21283 E7EV59 ATP6V1C1 V-type proton ATPase subunit C 1 0 21882700.0 4435100.0 10397000.0 7050600.0 False True 5814459.049569492 8845808.127188578 6321071.546130853 1.0 1.521346706852038 1.087129772906195 22.47121354557882 -12.263885465419136 11.946306316904787 1.041386262102828 1.273814415891205 0.0 0.2388149390529557 0.0 0.0 0.0 0.06583630458211792 5.446462710784044e-13 12.263885465419136 0.232428153788377 YGLPVNFQAMLLQPNKK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGLPVNFQAMLLQPNKK 17 1 E7EV59;P21283 E7EV59 ATP6V1C1 V-type proton ATPase subunit C 1 0 24342000.0 13342000.0 0.0 11000000.0 False True 20240789.430853747 0.0 8825845.178528722 1.0 0.0 0.43604253720831543 24.27076222330343 -10.69097770871382 6.281553793068506 1.00895477741221 0.218021268604162 0.8108982807431002 0.17801362038482013 0.022206628781528875 0.0010924581499187976 0.1714527972790074 0.057453648929041465 2.0371466368359288e-11 10.69097770871382 -0.790933508808048 YGLPVNFQAMLLQPNKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGLPVNFQAMLLQPNKK 17 1 E7EV59;P21283 E7EV59 ATP6V1C1 V-type proton ATPase subunit C 1 0 32418300.0 4435100.0 8461200.0 19522000.0 False True 6074876.324070888 8087356.206553283 14911305.668210518 1.0 1.3312791528789174 2.454585883358062 22.53442360710171 -6.948670160094434 0.5732561305813704 0.9862052777072351 2.854580514979007 0.999092759049667 0.018749510382957853 0.08402415109439261 0.03820634130047707 0.019790975066252544 0.09366969336684729 1.1254594183841853e-07 6.948670160094434 1.868375237271772 up YGLPVNFQAMLLQPNKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGLPVNFQAMLLQPNKK 17 1 E7EV59;P21283 E7EV59 ATP6V1C1 V-type proton ATPase subunit C 1 0 35880000.0 13342000.0 12428000.0 10110000.0 False True 17271482.010138366 11736370.874909984 8270083.737360132 1.0 0.6795230929239732 0.47882884239497164 24.041888545395878 -8.931816094944283 0.1202206429257125 1.5638007088243138 2.4708472622858785e-05 0.9999345549939006 0.0017363242226501232 0.41971275937947844 0.03728554920305461 0.26950340314922133 0.18891576964495796 1.1699947286397629e-09 8.931816094944283 -1.563776000351691 YGLTGK(ub)QQVSPIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGLTGKQQVSPIR 13 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 9337100.0 3032900.0 2500500.0 3803700.0 True False 3976161.2706453754 2127435.1468726606 3410129.611666797 1.0 0.5350474998533835 0.8576436868500796 21.922944842230887 -10.123505953346207 5.6540263567682505 1.0000033624756397 0.6963455933516978 0.5415687902054502 0.13169934185168403 5.58224628199672e-06 8.650668849452635e-07 0.12751875100219512 0.042505779808153024 7.524784150638844e-11 10.123505953346207 -0.30365776912394193 YGLTGK(ub)QQVSPIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGLTGKQQVSPIR 13 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 19260300.0 4267000.0 4759300.0 10234000.0 True False 4131546.4206377114 6659713.309421631 7553408.386580978 1.0 1.6119178223813089 1.8282278879526896 21.978250446805102 -11.012361556558377 0.20130360814464213 1.0282603373866275e-16 1.9965119714597235 0.9993751529082044 0.008767536164909873 3.1004215225834004 0.11188990775967406 1.5685448617040216 0.1336594824824922 9.719377343760112e-12 11.012361556558377 1.9965119714597235 YGLTGK(ub)QQVSPIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGLTGKQQVSPIR 13 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 9573000.0 5815900.0 3757100.0 0.0 True False 8823145.499243176 3086616.1506437133 0.0 1.0 0.34983171828102283 0.0 23.0728616454191 -8.498718309482058 0.5126849295068427 1.0506807646866896 8.668913533919756e-20 0.9934598795139705 0.03350811936916526 0.22130659822521234 0.18402420253325172 0.07932317727646529 0.06678347314631666 3.1716239633089414e-09 8.498718309482058 -1.0506807646866896 YGLTGK(ub)QQVSPIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGLTGKQQVSPIR 13 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 13255000.0 3032900.0 3536200.0 6685900.0 True False 4154245.091040695 3379958.9913503667 5106828.120432788 1.0 0.813615691245516 1.2293035217027741 21.98615490375378 -6.784855420155717 1.517271438024906 0.8951276234953341 1.233092286010007 0.7840776883410641 0.07899701740180902 0.24311181339566884 1.1057302974644656 0.04099833052650442 0.09634084133018067 1.6411360285870604e-07 6.784855420155717 0.33796466251467294 YGLTGK(ub)QQVSPIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGLTGKQQVSPIR 13 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 4267000.0 4267000.0 0.0 0.0 True False 3548199.560151177 0.0 0.0 1.0 0.0 0.0 21.75865572223938 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 YGLTGK(ub)QQVSPIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGLTGKQQVSPIR 13 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 24171800.0 5815900.0 5280900.0 13075000.0 True False 7528797.198528246 4987013.272715811 10695484.160829237 1.0 0.6623917660699757 1.4206099432350263 22.84398796751155 -6.7856479637401526 1.5135473623051472 0.8102384526603786 1.4277492061082513 0.7869581079871865 0.14315836917103342 0.24190031612107704 1.0947476279155919 0.07446719806235777 0.17492417311089373 1.638143852059378e-07 6.7856479637401526 0.6175107534478727 YGLVFAGGASGLQIFPTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGLVFAGGASGLQIFPTK 18 0 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A494BZU9 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 0 16988900.0 7835000.0 3749700.0 5404200.0 False True 7586282.213662165 5246974.764427172 3988677.8974751653 1.0 0.6916398067788561 0.5257750483223442 22.854961610963933 -13.999998706758268 0.07674869827320158 2.698599395894625 1.6860497488646845e-08 0.9999014641073692 0.0019504867127561065 12.218131146660037 0.07653307702680653 3.5787402531138093 0.476752454290994 1.0000029778035682e-14 13.999998706758268 -2.6985993790341274 YGLVFAGGASGLQIFPTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGLVFAGGASGLQIFPTK 18 0 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A494BZU9 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 0 18039600.0 7835000.0 3686700.0 6517900.0 False True 6515149.649351878 3666839.015347349 7880762.754635408 1.0 0.5628173123716541 1.20960579246547 22.63536688639821 -6.724646859764702 1.7425137118344183 0.7353454340556504 1.2088740663898205 0.5343097161040067 0.18387235689767575 0.34640476681534843 2.057929705648519 0.0837047589839899 0.20899696644424842 1.8851813742169587e-07 6.724646859764702 0.4735286323341701 YGLVFAGGASGLQIFPTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGLVFAGGASGLQIFPTK 18 0 A0A494C1F2;P35658-2;P35658-4;P35658;P35658-3;P35658-5;A0A494BZU9 A0A494C1F2 NUP214 Nuclear pore complex protein Nup214 0 65743000.0 26917000.0 22680000.0 16146000.0 False True 34844587.1133934 21417838.06267768 13207593.671950215 1.0 0.6146675807343744 0.3790429092750977 25.05443122414502 -8.822412786118957 0.15791970451121481 1.4525614674391514 2.723688425735171e-07 0.9998377773676321 0.0032599280791349374 0.33830028352756253 0.04688185209712795 0.23062667571479226 0.15782071772563483 1.5051757539094078e-09 8.822412786118957 -1.4525611950703088 YGLVFFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGLVFFR 7 0 Q96T58;H0Y5U7;F6WRY4;A0A669KB49 Q96T58 SPEN Msx2-interacting protein 0 9517500.0 2538000.0 3294000.0 3685500.0 False True 3327342.5780269657 2802548.0399114373 3304159.8138123415 1.0 0.8422781767104008 0.9930326488268091 21.665938980834067 -10.591818445481609 7.520403413897195 1.0000701366632994 0.9176554127707282 0.2845917855530192 0.06154525552130577 7.243558255689216e-05 3.931566487002944e-06 0.059641608311265165 0.019863645806008107 2.5596557138479877e-11 10.591818445481609 -0.0824147238925712 YGLVFFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGLVFFR 7 0 Q96T58;H0Y5U7;F6WRY4;A0A669KB49 Q96T58 SPEN Msx2-interacting protein 0 9844400.0 3250600.0 1293300.0 5300500.0 False True 3147411.482288483 1809721.4344704028 3912140.0384084894 1.0 0.5749872378156777 1.2429706317154223 21.58573437352448 -6.734800882714168 1.7056267165913588 0.7456056288442326 1.242941751290115 0.5813958406961713 0.1786085213867673 0.327320930964109 1.8675503912122384 0.08291105300607518 0.20463719241494954 1.8416161603909284e-07 6.734800882714168 0.49733612244588243 YGLVFFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGLVFFR 7 0 Q96T58;H0Y5U7;F6WRY4;A0A669KB49 Q96T58 SPEN Msx2-interacting protein 0 9858400.0 2538000.0 3059000.0 4261400.0 False True 3476367.186871083 2923843.2652397375 3254945.0862878994 1.0 0.8410628417740168 0.9363064691729313 21.72914904235696 -10.222732351242888 4.865023644753539 1.000018413189884 0.8886846554771572 0.6455510732976755 0.03888304806388206 7.766914146626502e-06 1.240840354235247e-06 0.037654575314284025 0.012549449800000372 5.987805002381903e-11 10.222732351242888 -0.11133375771272669 YGLVFFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGLVFFR 7 0 Q96T58;H0Y5U7;F6WRY4;A0A669KB49 Q96T58 SPEN Msx2-interacting protein 0 6767700.0 3250600.0 1692800.0 1824300.0 False True 2703017.925996585 1683680.550405509 2205752.695389833 1.0 0.6228891544567716 0.8160333211910115 21.366139648958757 -10.130064913396076 4.757354690876157 1.0000181165074267 0.7194612378238255 0.7377355537352446 0.07885077590166109 110100675.62804024 2.0347938330237025 24590.641369647197 0.02699271789581607 7.411994469638815e-11 10.130064913396076 -0.28055687868360113 YGMGTSVER ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGMGTSVER 9 0 P08559;P08559-4;P08559-3;P08559-2 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 0 4338600.0 776300.0 1759500.0 1802800.0 False True 1017736.8176998936 1496989.458477283 1616263.5496787112 1.0 1.4709003668163545 1.5880957842632641 19.95693310432491 -11.800578352464294 0.23563157053737666 8.01054503465656e-09 1.6485441315420617 0.9993478143416133 0.006490509139822254 4.685788866615635 0.1377779182879267 2.37919222888535 0.05854392560115021 1.5827839857963706e-12 11.800578352464294 1.6485441235315166 YGMGTSVER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGMGTSVER 9 0 P08559;P08559-4;P08559-3;P08559-2 P08559 PDHA1 Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial 0 4247100.0 776300.0 1441500.0 2029300.0 False True 1063319.0887186832 1377809.7635969545 1550021.134745397 1.0 1.295763217471472 1.4577196546082865 20.020143165847802 -11.55402972808718 0.09523059688770766 2.5193061869138233e-26 1.8862197387737507 0.9998886850177579 0.0019993931028144275 4.576654836640002 0.06523037722387952 1.2606482972160116 0.30227261841349373 2.79235269410337e-12 11.55402972808718 1.8862197387737507 YGMWHFLLGDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGMWHFLLGDK 11 0 Q8N1B9;C9J6X0;A0A087WXC5;E7ESZ7;O95299;O95299-2 Q8N1B9 NDUFA10 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 0 7379380.0 1686600.0 3354780.0 2338000.0 False True 2211148.9330576337 2854259.900830021 2096086.1876796237 1.0 1.290849231436924 0.9479624625651524 21.076364771207096 -6.681946216527472 1.8950346896164052 1.1837011359542278 0.9492487909315522 0.33304377676503616 0.12321661147078633 0.43420381597889396 3.0164135908022573 0.05214219661675005 0.13717648407791333 2.0799542548154623e-07 6.681946216527472 -0.23445234502267553 YGMWHFLLGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGMWHFLLGDK 11 0 Q8N1B9;C9J6X0;A0A087WXC5;E7ESZ7;O95299;O95299-2 Q8N1B9 NDUFA10 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 0 9932700.0 3521600.0 2102900.0 4308200.0 False True 3409808.73562638 2942598.9364786264 3179753.176770386 1.0 0.8629806433814747 0.9325312424558226 21.701259386608186 -10.110408251773062 4.429457919336822 1.000010115032812 0.8977559429688954 0.7423652154000915 0.028393913206844774 39569970.582485825 0.2559192919631333 4733.206840039934 0.00971999171929926 7.755177604634675e-11 10.110408251773062 -0.10225417206391663 YGMWHFLLGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGMWHFLLGDK 11 0 Q8N1B9;C9J6X0;A0A087WXC5;E7ESZ7;O95299;O95299-2 Q8N1B9 NDUFA10 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 0 13745800.0 1686600.0 3588600.0 8470600.0 False True 2310181.598651206 3430043.786086739 6470018.737483046 1.0 1.4847507174714585 2.8006537413597923 21.139574832729988 -6.953673880984476 0.5169401324109743 0.9770988148325983 3.36672381754657 0.9994589484108506 0.017695899842076868 0.08204318476434463 0.03011016924286409 0.02014626676072611 0.1086631638907944 1.1125668588124643e-07 6.953673880984476 2.389625002713972 YGMWHFLLGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGMWHFLLGDK 11 0 Q8N1B9;C9J6X0;A0A087WXC5;E7ESZ7;O95299;O95299-2 Q8N1B9 NDUFA10 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial 0 11282500.0 3521600.0 3762500.0 3998400.0 False True 2928366.4333321736 3742230.665702224 4834446.953487198 1.0 1.277924314083862 1.6509023250844004 21.481664662042462 -6.967040703814247 0.32110620139942797 0.9495792765000548 1.9912971752178792 0.9999492413217935 0.0018999033155029201 0.07727513363866793 0.012453383490610318 0.0056284977539622395 0.03277606485203969 1.0788456037703317e-07 6.967040703814247 1.0417178987178244 YGPIADVSIVYDQQSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGPIADVSIVYDQQSR 16 0 P62995-3;P62995 P62995-3 TRA2B Transformer-2 protein homolog beta 0 20332800.0 6189400.0 7917400.0 6226000.0 False True 8114363.33823486 6736154.78178348 5581793.2440091185 1.0 0.8301519787809766 0.6878904741309428 22.952046473117267 -6.973169021064139 0.16585963216432378 1.1329242478076371 0.38132328588345527 0.9999977249712351 0.00019235081827417524 0.0752872196071867 0.005150923561680059 0.006229745484468872 0.016716739246346302 1.0637289498964293e-07 6.973169021064139 -0.7516009619241819 YGPIADVSIVYDQQSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGPIADVSIVYDQQSR 16 0 P62995-3;P62995 P62995-3 TRA2B Transformer-2 protein homolog beta 0 47982700.0 17773000.0 9990700.0 20219000.0 False True 17208805.843448356 13980038.610812215 14923037.343001842 1.0 0.8123770317354484 0.8671744848979897 24.036643653309103 -9.826576355741656 5.617883239128848 1.000000040979929 0.8397757583157041 0.9193496415131146 0.022370966578963352 1.1479835557305403e-08 2.41305543819179e-09 0.02166060073521068 0.0072201984160531465 1.4908146239535702e-10 9.826576355741656 -0.16022428266422495 YGPIADVSIVYDQQSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGPIADVSIVYDQQSR 16 0 P62995-3;P62995 P62995-3 TRA2B Transformer-2 protein homolog beta 0 219534000.0 34505000.0 120550000.0 64479000.0 False True 52346607.653396 99036910.63855095 51734697.38785032 1.0 1.8919451532429132 0.9883104122124333 25.641592709864238 -6.6490790936777895 2.0111653914892336 1.5791691388619553 0.992052730010085 0.19065373036324695 0.3807704822680489 0.510737644642036 3.958435748362761 0.15357855454474395 0.42190588248819316 2.2434733053885298e-07 6.6490790936777895 -0.5871164088518703 YGPIADVSIVYDQQSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGPIADVSIVYDQQSR 16 0 P62995-3;P62995 P62995-3 TRA2B Transformer-2 protein homolog beta 0 21075900.0 6189400.0 5905200.0 8981300.0 False True 8477788.442245806 5644288.738114981 6860101.915679708 1.0 0.6657737187671297 0.809185315535243 23.01525653464016 -10.109577631737883 4.773667629449254 1.0000147428917483 0.7374795171485362 0.817112068958073 0.05854753922238874 14874331.184861764 31500560.722944256 1458.2153583433835 0.020042381530481615 7.770024143364171e-11 10.109577631737883 -0.2625352257432121 YGPIADVSIVYDQQSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGPIADVSIVYDQQSR 16 0 P62995-3;P62995 P62995-3 TRA2B Transformer-2 protein homolog beta 0 34416900.0 17773000.0 7979600.0 8664300.0 False True 14779036.97740027 7936612.310973405 10475965.070803117 1.0 0.5370182321831843 0.7088394925070354 23.81704892874338 -10.041995242549493 4.981684942077699 1.0000063671549166 0.6229288623421244 0.8652550151854241 0.07014573580290469 4.960552481925116e-06 9.540552376891948e-07 0.0679194629420315 0.022639438879530176 9.07830474893297e-11 10.041995242549493 -0.37707750481279223 YGPIADVSIVYDQQSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGPIADVSIVYDQQSR 16 0 P62995-3;P62995 P62995-3 TRA2B Transformer-2 protein homolog beta 0 146823000.0 34505000.0 62951000.0 49367000.0 False True 44667402.695234984 59447721.511623695 40382712.548195615 1.0 1.330897207460989 0.9040756818507281 25.412719031956687 -6.699773335431889 1.8319551497094166 1.2055245521408988 0.9053629733746328 0.41636088972750285 0.13968222373402556 0.396001924620369 2.5836885858891723 0.06083622159388366 0.15648239135645475 1.9963039430105824e-07 6.699773335431889 -0.30016157876626604 YGPIVDVYVPLDFYTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGPIVDVYVPLDFYTR 16 0 Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3;O75494-2;O75494;Q6IQ42 Q5JRI1 SRSF10;FUSIP1 Serine/arginine-rich splicing factor 10 0 243327000.0 71498000.0 90300000.0 81529000.0 False True 108467693.20395616 74185259.48287986 65414757.41456992 1.0 0.6839387590126614 0.6030805623529573 26.692690163105905 -13.999999999999998 0.19141262297152772 2.7026286348297224 0.545889415284242 0.9994886922155494 0.003872604667147706 12.37408694626002 0.1387438303163721 7.861793447588172 0.054989051032159786 1.0000000000000041e-14 13.999999999999998 -2.1567392195454804 YGPIVDVYVPLDFYTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGPIVDVYVPLDFYTR 16 0 Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3;O75494-2;O75494;Q6IQ42 Q5JRI1 SRSF10;FUSIP1 Serine/arginine-rich splicing factor 10 0 169806000.0 71498000.0 42909000.0 55399000.0 False True 92555570.43628201 40521076.42995756 45316950.44174219 1.0 0.4378026761539271 0.4896188336167159 26.463816485198354 -10.48417934837831 9.559704498892735 1.0000062850115996 0.4637107558326213 0.9930471414554272 0.021153857702589873 2.83363916596549e-06 1.5289942828722452e-07 0.020482374149004546 0.006827378215847681 3.279598292452737e-11 10.48417934837831 -0.5362955291789784 YGPLSGVNVVYDQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGPLSGVNVVYDQR 14 0 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 0 33044800.0 10630000.0 9952800.0 12462000.0 False True 13936032.941066435 8467881.035710534 11172551.783945011 1.0 0.6076249296711652 0.8017024522826686 23.732316603411427 -10.135064184450737 5.089690543941415 1.0000116966389367 0.7046636909764458 0.7553580535830774 0.07923181682524644 1.0516444720575421e-05 1.787188854483849e-06 0.07671891387877615 0.025571958920926275 7.327162368870456e-11 10.135064184450737 -0.295348005662491 YGPLSGVNVVYDQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGPLSGVNVVYDQR 14 0 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 0 26488900.0 7570700.0 3447200.0 15471000.0 False True 7330372.272491661 4823684.936910522 11418680.979948614 1.0 0.6580409231072936 1.5577218394213013 22.80545503672005 -6.803690374488977 1.4406741783579429 0.8122005688458629 1.5713218431147988 0.8427729234575776 0.1470280424439704 0.21552705507320907 0.882705357421511 0.08027034308541321 0.18628611675248127 1.5714827765446503e-07 6.803690374488977 0.7591212742689359 YGPLSGVNVVYDQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGPLSGVNVVYDQR 14 0 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 0 28871100.0 10630000.0 7113100.0 11128000.0 False True 14560198.26494861 6798819.72212383 8499795.588353999 1.0 0.46694554554871137 0.5837692202870562 23.795526664934318 -9.797854118815868 6.354414912136599 1.0000000109001634 0.5253573829177963 0.9565397176437209 0.047693065498365085 7.339159599136847e-09 1.3536159080923142e-09 0.04617861313303591 0.01539287070028824 1.5927436459121767e-10 9.797854118815868 -0.4746426279823671 YGPLSGVNVVYDQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGPLSGVNVVYDQR 14 0 Q13595-2;Q13595-4;Q13595-3;Q13595 Q13595-2 TRA2A Transformer-2 protein homolog alpha 0 13886800.0 7570700.0 6316100.0 0.0 False True 6295372.488876614 6282073.915652311 0.0 1.0 0.9978875637227503 0.0 22.585860312154328 -7.025132561884062 1.084939183537472 1.0212881248211507 7.770638636610523e-18 0.9860610893733215 0.055596817692922317 0.0876693877816347 0.20029246955293914 0.04316194879716517 0.07812341761448702 9.437727598210785e-08 7.025132561884062 -1.0212881248211507 down YGPQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGPQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSK 35 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 17115000.0 3597300.0 8765800.0 4751900.0 False True 4716095.1363027515 7457976.8088207785 4260218.971443451 1.0 1.5813881173456488 0.9033360965621463 22.169161390968355 -6.67975383375682 1.9031465182197533 1.3679360436132848 0.9059430345231784 0.3228886916981214 0.24641963115735818 0.43903296936135283 3.074318937294089 0.10391391340959764 0.27411382401922857 2.0904807187082658e-07 6.67975383375682 -0.46199300909010643 YGPQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGPQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSK 35 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 28099300.0 7455300.0 5793000.0 14851000.0 False True 7218635.582324902 8106175.1100959135 10961077.579549938 1.0 1.122951147436253 1.5184417407617232 22.783294743745163 -6.949873242572788 0.5602316122053617 0.994833776939355 1.665467818166765 0.9991913112068208 0.0062899813023572105 0.08353665164992226 0.03617304665806823 0.006740616057700951 0.032877656694926406 1.1223459853574254e-07 6.949873242572788 0.67063404122741 YGPQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGPQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSK 35 0 P14866;M0QXS5;A0A3B3ITJ4;P14866-2 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 15330700.0 7455300.0 5112400.0 2763000.0 False True 6199412.275789804 5084858.486468059 3340730.5253314176 1.0 0.8202162173220282 0.5388785866650253 22.56370001917944 -6.964544091934742 0.36579246852798236 1.0226938496784366 0.3266723915328546 0.9999034359063393 0.00186478193385414 0.07811601450686756 0.015407522820442169 0.003733693686193201 0.023949150922431703 1.0850653823091672e-07 6.964544091934742 -0.6960214581455819 YGQHPPDAVDEPQMLTNEK(ub)LSIFDANESGFESYEALPQHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHK 40 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 119592000.0 70565000.0 11150000.0 37877000.0 True False 68324952.7003282 15602253.146481847 27955877.414356798 1.0 0.22835366187391304 0.4091605820346585 26.025909220218335 -10.699590152758063 10.079654320057614 1.0006386671232106 0.31875712200725803 0.949820212227272 0.0738141160596605 0.001060164513070513 3.1596638102969905e-05 0.07152148880140509 0.023823403517840548 1.997146149031253e-11 10.699590152758063 -0.6818815451159526 YGQHPPDAVDEPQMLTNEK(ub)LSIFDANESGFESYEALPQHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHK 40 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 210170000.0 73361000.0 98611000.0 38198000.0 True False 111294000.40749995 81013096.59874028 30648148.557221852 1.0 0.7279197108749171 0.2753800604255799 26.7298005816472 -7.050624648565798 0.4027844904825894 1.0255444744666582 2.45667758307514e-12 0.9998497161769807 0.003663816240544622 0.07335886506269156 0.018370656135650573 0.0060570593254225605 0.03555637188006627 8.899699675726737e-08 7.050624648565798 -1.0255444744642015 down YGQHPPDAVDEPQMLTNEK(ub)LSIFDANESGFESYEALPQHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHK 40 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 110614000.0 70565000.0 22790000.0 17259000.0 True False 58677924.05954256 22667225.746539194 20867777.103400275 1.0 0.3862990402240195 0.35563250469162827 25.80631449565261 -13.661424481379148 0.4300862414227975 9.998764724903637 0.3549904946975692 0.9998716001155077 0.0033630740398294017 23.359740719946522 0.21978629533803778 196.18215447306648 0.007258362509979954 2.180597544076552e-14 13.661424481379148 -9.643774230206068 YGQHPPDAVDEPQMLTNEK(ub)LSIFDANESGFESYEALPQHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQHK 40 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 204476800.0 73361000.0 101347800.0 29768000.0 True False 94967260.66150226 95707705.8381239 24350529.445473395 1.0 1.0077968467392238 0.2564097276878135 26.50092690373965 -6.90455768204157 0.9320260346481455 1.0274547803659964 0.16981942806696132 0.9886999916210606 0.03745893868359599 0.10812717862554518 0.15911244724573287 0.029865713632131294 0.07964005069096114 1.245782764144811e-07 6.90455768204157 -0.857635352299035 down YGQISEVVVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGQISEVVVVK 11 0 Q14011;K7ENX8;K7ELV6;K7EJV5;K7ELT6;K7EJV1;K7EMY9;K7EPM4;K7ER40;K7EQR7;D6W5Y5;Q14011-2 Q14011 CIRBP Cold-inducible RNA-binding protein 0 11757600.0 2698900.0 4643400.0 4415300.0 False True 3538284.036184775 3950622.8198314323 3958447.110548261 1.0 1.1165363717072498 1.118747695229277 21.7546184345225 YGQISEVVVVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGQISEVVVVK 11 0 Q14011;K7ENX8;K7ELV6;K7EJV5;K7ELT6;K7EJV1;K7EMY9;K7EPM4;K7ER40;K7EQR7;D6W5Y5;Q14011-2 Q14011 CIRBP Cold-inducible RNA-binding protein 0 12944500.0 3845800.0 2213200.0 6885500.0 False True 3723717.184084489 3096942.3016855316 5081980.989427722 1.0 0.8316803206543582 1.3647601947721963 21.82831207385009 -6.821800027480447 1.363971527007338 0.9094377162814063 1.3768631429484373 0.8884974825821983 0.07429713481804937 0.19114920307929462 0.6982578715622627 0.04279851710107044 0.09860422664694722 1.5073009487870525e-07 6.821800027480447 0.4674254266670309 YGQISEVVVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGQISEVVVVK 11 0 Q14011;K7ENX8;K7ELV6;K7EJV5;K7ELT6;K7EJV1;K7EMY9;K7EPM4;K7ER40;K7EQR7;D6W5Y5;Q14011-2 Q14011 CIRBP Cold-inducible RNA-binding protein 0 13052600.0 2698900.0 4299000.0 6054700.0 False True 3696756.265030081 4109055.965108086 4624704.560460726 1.0 1.1115301281770196 1.251016899385195 21.81782849604539 -6.968101912032847 0.3000803667172036 0.975831419847594 1.3910868123484192 0.9999635582499167 0.0006198749660780858 0.0769235262432979 0.011222902764307133 0.0023132058748658916 0.012508876765177653 1.076212638724864e-07 6.968101912032847 0.4152553925008252 YGQISEVVVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGQISEVVVVK 11 0 Q14011;K7ENX8;K7ELV6;K7EJV5;K7ELT6;K7EJV1;K7EMY9;K7EPM4;K7ER40;K7EQR7;D6W5Y5;Q14011-2 Q14011 CIRBP Cold-inducible RNA-binding protein 0 6244900.0 3845800.0 1293700.0 1105400.0 False True 3197953.0978273726 1286730.581320656 1336534.0292078715 1.0 0.4023606794592566 0.41793421864626057 21.608717349284365 -10.0336886414297 6.448536831208715 1.0000003462972413 0.4101474490947958 0.9994774566314625 0.006357870749584875 3.165077822680321e-08 4.736973993762281e-09 0.006155985459966631 0.0020519939608707252 9.253613551312502e-11 10.0336886414297 -0.5898528972024455 YGQISEVVVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGQISEVVVVK 11 0 Q14011;K7ENX8;K7ELV6;K7EJV5;K7ELT6;K7EJV1;K7EMY9;K7EPM4;K7ER40;K7EQR7;D6W5Y5;Q14011-2 Q14011 CIRBP Cold-inducible RNA-binding protein 0 10380200.0 2584700.0 4167500.0 3628000.0 False True 3345945.1020540153 3935574.96147307 2967741.22642359 1.0 1.1762222156774453 0.8869665030074005 21.673982344155263 -6.741788735094562 1.6799616218659001 1.1046310632725014 0.8867230521634548 0.6130528206975747 0.07403876777970696 0.3145752935832603 1.7438700395575761 0.03485426661125003 0.08536802228373633 1.8122214431801246e-07 6.741788735094562 -0.21790801110904656 YGQLIEINSHSLFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGQLIEINSHSLFSK 15 0 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 33662900.0 9812900.0 11590000.0 12260000.0 False True 12864806.92825879 9860817.177466152 10991452.80622419 1.0 0.7664955434197707 0.854381481783485 23.616926469846504 -10.344333101088958 4.825650998504342 1.0001299362959517 0.8104385126015186 0.8611685090727013 0.035879284093175576 5.0191326376980876e-05 6.819494187280461e-06 0.03476370745165902 0.011579989147172553 4.525503435385785e-11 10.344333101088958 -0.18969142369443315 YGQLIEINSHSLFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGQLIEINSHSLFSK 15 0 Q15645;H0YAL2 Q15645 TRIP13 Pachytene checkpoint protein 2 homolog 0 43143000.0 10052000.0 18425000.0 14666000.0 False True 15249618.899635883 15136914.794817949 11767258.671663845 1.0 0.9926093822042579 0.7716428029519357 23.86226985321654 -6.9140087220722135 0.8679834629018673 1.006005023023313 0.7404948853003471 0.9923486069101581 0.009267647255163968 0.10182661721287709 0.12482728101505881 0.007741266747603508 0.02201245139895218 1.21896511782048e-07 6.9140087220722135 -0.26551013772296594 YGQNCHK(ub)GPPHSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGQNCHKGPPHSK 13 1 O15355 O15355 PPM1G Protein phosphatase 1G 1 10365600.0 5529400.0 2663400.0 2172800.0 True False 4597941.093953577 2649051.7355564907 2627122.434107889 1.0 0.5761386849953491 0.5713693108340665 22.13255655256047 YGSDIVPFSK(ub)VDEEQMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGSDIVPFSKVDEEQMK 17 1 P13010 P13010 XRCC5 X-ray repair cross-complementing protein 5 1 22237400.0 2816200.0 3622200.0 15799000.0 True False 3645626.4156012353 3420621.385830299 12923744.111429546 1.0 0.9382808318460605 3.5449995798042204 21.797735298563587 -6.901479315852428 0.9518863542159418 0.8959773517951213 3.826972038844203 0.9872875270338326 0.13693811894836852 0.11032397217040701 0.17134982272209165 0.107589941447708 0.2820608718882364 1.2546444914006082e-07 6.901479315852428 2.9309946870490817 up YGSPYPWPLNHILAYQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGSPYPWPLNHILAYQK 17 0 O75431-2;O75431;C9JNK6 O75431-2 MTX2 Metaxin-2 0 22682200.0 6246600.0 13145100.0 3290500.0 False True 8189353.092160456 11183902.319198469 2950030.6247047856 1.0 1.3656637091279713 0.36022755295882963 22.965318061777378 -6.808287220273628 1.4216305417150892 1.199688970389934 0.343302576472333 0.8553395972176889 0.15804035317870946 0.2091393657334405 0.8333638304088296 0.0874189498623165 0.20238792185504975 1.5549369353043363e-07 6.808287220273628 -0.8563863939176011 down YGSPYPWPLNHILAYQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGSPYPWPLNHILAYQK 17 0 O75431-2;O75431;C9JNK6 O75431-2 MTX2 Metaxin-2 0 119286300.0 61252000.0 33223000.0 24811300.0 False True 59307588.78764962 46489117.15565622 18312476.206954904 1.0 0.7838645627983656 0.3087712142964131 25.821713382909046 -6.958156650004584 0.4606841316286411 1.0137539273339287 0.05970814390511176 0.9996955838046727 0.005037420830151534 0.08036638164787069 0.02361553438541174 0.00645983682617191 0.03924454653815171 1.1011420559995829e-07 6.958156650004584 -0.9540457834288169 down YGSPYPWPLNHILAYQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGSPYPWPLNHILAYQK 17 0 O75431-2;O75431;C9JNK6 O75431-2 MTX2 Metaxin-2 0 414249000.0 150085000.0 113987000.0 150177000.0 False True 227689917.68323246 93645129.26550399 120494450.12508257 1.0 0.4112836010410671 0.5292041533991736 27.762495168138454 -10.743752152596342 16.000329038094403 1.0000420751924541 0.47024387722061517 0.9641703885204903 0.04814086391075143 7.226119881754064e-05 1.1572336484239275e-06 0.04661578124901038 0.01553739701653148 1.8040469982452875e-11 10.743752152596342 -0.5297981979718389 YGSPYPWPLNHILAYQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGSPYPWPLNHILAYQK 17 0 O75431-2;O75431;C9JNK6 O75431-2 MTX2 Metaxin-2 0 30392200.0 6246600.0 7740700.0 16404900.0 False True 8556136.82801769 7398690.278928159 12530400.489520906 1.0 0.864723230547297 1.4644927659979914 23.02852812330027 -6.847450020183339 1.2472699228772492 0.9279371608551019 1.487323507827785 0.9365202946349596 0.06471542656487099 0.16028481449267723 0.4811136842729714 0.040624991149516454 0.09387178745315795 1.420855719478909e-07 6.847450020183339 0.5593863469726832 YGSPYPWPLNHILAYQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGSPYPWPLNHILAYQK 17 0 O75431-2;O75431;C9JNK6 O75431-2 MTX2 Metaxin-2 0 112615000.0 61252000.0 51363000.0 0.0 False True 50933751.92368871 51086297.32424275 0.0 1.0 1.0029949767058706 0.0 25.602118658343322 -7.021248565860824 1.0904601539161505 1.0228824361671036 1.3669830537979584e-17 0.9856963835611827 0.056463525278238065 0.08820654633474037 0.20383653811700364 0.0436257842447795 0.07911023870996191 9.522509928399723e-08 7.021248565860824 -1.0228824361671036 down YGSPYPWPLNHILAYQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGSPYPWPLNHILAYQK 17 0 O75431-2;O75431;C9JNK6 O75431-2 MTX2 Metaxin-2 0 285727000.0 150085000.0 82054000.0 53588000.0 False True 194287991.11764497 77487622.76873696 43835533.859313026 1.0 0.3988286786176958 0.22562142727992798 27.533621490230903 -13.999999999999998 0.17450002478575766 4.069091019617614 0.07992896515291423 0.9995058146005619 0.007376930755743766 12.138510794972401 0.1323601518774059 12.617623931545072 0.13563134647122402 1.0000000000000041e-14 13.999999999999998 -3.9891620544647 YGTCPHGGYGLGLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGTCPHGGYGLGLER 15 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 32188000.0 7858100.0 7861900.0 16468000.0 False True 10302045.197948651 6688935.165446182 14764049.332210436 1.0 0.6492822577383067 1.4331182836540324 23.296427438905212 -6.785052375193511 1.5159057070779192 0.8027170661993709 1.4403713036024595 0.7849436833280543 0.14867027325828852 0.24280500374386535 1.102259213488488 0.0772170126574787 0.18146734961416613 1.6403919327264192e-07 6.785052375193511 0.6376542374030886 YGTCPHGGYGLGLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGTCPHGGYGLGLER 15 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 8363500.0 4505700.0 1055800.0 2802000.0 False True 4362669.019795483 1477386.4459242662 2068072.1418018246 1.0 0.3386427985301357 0.47403828537484916 22.056779595041228 -9.875376605606617 6.717332810213566 1.0000000165602856 0.4063405419557277 0.9624530707384041 0.05527497604093796 1.3728705707023063e-08 2.2557505506582335e-09 0.053519767012124235 0.017839921805704834 1.332365548353617e-10 9.875376605606617 -0.5936594746045578 YGTCPHGGYGLGLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGTCPHGGYGLGLER 15 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 28874100.0 7858100.0 10345000.0 10671000.0 False True 10763451.927167704 9887923.693659732 8150729.576143563 1.0 0.918657300703125 0.757259811378035 23.359637500428104 -6.9602000480804405 0.43260603901016575 1.0062365407413296 0.6634645467132266 0.9997775416950402 0.0015045981780777344 0.07962974764466704 0.020867913398456613 0.0021100594594547 0.013393077952840667 1.0959732441893628e-07 6.9602000480804405 -0.342771994028103 YGTCPHGGYGLGLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGTCPHGGYGLGLER 15 0 O43776 O43776 NARS Asparagine--tRNA ligase, cytoplasmic 0 12833300.0 3004400.0 3727300.0 6101600.0 False True 3889255.025577856 3519872.4784399695 4991171.407702918 1.0 0.9050248583061213 1.2833232521082472 21.891062407355097 -6.840202038618093 1.2814846598857799 0.9494773977013906 1.295813539880237 0.9247979964291468 0.04406699075880851 0.16856174665870058 0.5376285410210907 0.02696361715573927 0.06212135124090477 1.444767492493188e-07 6.840202038618093 0.34633614217884645 YGVAWEK(ub)YCQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGVAWEKYCQR 11 1 Q14739 Q14739 LBR Lamin-B receptor 1 11523900.0 2605400.0 2220500.0 6698000.0 True False 3415704.6307294895 1889210.0554412059 6004955.211752823 1.0 0.5530952642815983 1.7580428816148395 21.703751794222352 -6.806266749609565 1.4300210640584905 0.7553437120932762 1.7773992870032178 0.8498948303168452 0.19269200409392365 0.2119341215317477 0.8548322992879539 0.10597086694693666 0.24558947941022627 1.5621878307784708e-07 6.806266749609565 1.0220555749099416 YGVAWEK(ub)YCQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGVAWEKYCQR 11 1 Q14739 Q14739 LBR Lamin-B receptor 1 9728700.0 2605400.0 2209700.0 4913600.0 True False 3568686.788287591 2112068.147499266 3753108.878768532 1.0 0.5918334313986482 1.0516778583893136 21.766961855745244 -6.6724872863580105 1.928327023544891 0.7400321449453354 1.0498503035343032 0.2902112203027276 0.1732807834023383 0.45543102790973367 3.267164435025952 0.0722781917581999 0.19250114728158754 2.1257525741026484e-07 6.6724872863580105 0.3098181585889678 YGVFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGVFLR 6 0 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 0 8701700.0 2456900.0 2346200.0 3898600.0 False True 3221019.6926534423 1996156.1054159722 3495210.270011877 1.0 0.619728004137584 1.085125396154458 21.6190860504133 -6.689463412395128 1.8680734453542132 0.761479654966944 1.083518401369777 0.36805226592443474 0.1608449176722484 0.4178090725252407 2.8263776193391297 0.06888743260383753 0.17952556782251125 2.044262149807574e-07 6.689463412395128 0.3220387464028329 YGVFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGVFLR 6 0 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 0 5714160.0 1267600.0 686360.0 3760200.0 False True 1227360.7318491612 960427.127320117 2775290.816417999 1.0 0.7825141398104877 2.26118592879919 20.227127901098864 -6.869517251947532 1.1367012961225225 0.8773593524821062 2.346973074048585 0.9641961845198265 0.12334535546546616 0.13731567623595325 0.33191529962418237 0.08424074830941847 0.19927009598291912 1.3504631808858376e-07 6.869517251947532 1.4696137215664786 up YGVFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGVFLR 6 0 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 0 7003700.0 2456900.0 1662800.0 2884000.0 False True 3365282.3252259837 1589331.9978557178 2202858.5978444424 1.0 0.4722730054302329 0.6545835935760655 21.682296111936193 -10.043144294685044 5.649542384496052 1.000001714978648 0.5634282995030053 0.8843376517198471 0.07442798594450828 1.6077112360904883e-06 2.7238196792778885e-07 0.07206487097263498 0.024021529171162383 9.054317205119564e-11 10.043144294685044 -0.43657341547564266 YGVFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGVFLR 6 0 Q96QR8 Q96QR8 PURB Transcriptional activator protein Pur-beta 0 4256100.0 1267600.0 1934100.0 1054400.0 False True 1054065.564201462 1923680.619411207 1274870.1650052266 1.0 1.825010402335406 1.2094790004557652 20.00753317653314 -10.378401658040845 5.333041291736315 0.9997495699583103 1.5172447013955979 0.48494012954196586 0.2512896425442321 0.0007485897318423868 8.725275298351434e-05 0.24342562208501073 0.08110338338734578 4.184064221806522e-11 10.378401658040845 0.5174951314372875 YGVIIVGNPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGVIIVGNPK 10 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 34024600.0 9926600.0 10606000.0 13492000.0 False True 13013868.72933113 9023626.141864207 12095977.264402673 1.0 0.6933853667608026 0.9294682093373449 23.633546570688978 -10.396090415372882 5.638776242758499 1.0000741592604006 0.8114267880490996 0.4596601637172867 0.09638041688972501 8.989072328342211e-05 9.627176339307225e-06 0.09335655058723652 0.03110664579286908 4.0170717109249365e-11 10.396090415372882 -0.18864737121130093 YGVIIVGNPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGVIIVGNPK 10 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 25023300.0 7646500.0 4454800.0 12922000.0 False True 7403766.042982483 6233624.871475109 9537340.548309498 1.0 0.8419532485610522 1.2881742201118418 22.819827876477312 -6.810976903041023 1.4105045637695754 0.9139641996717773 1.2961497422602575 0.862333400294081 0.06854229148011863 0.20547867368255293 0.8055453894478266 0.03820837784806507 0.08834196885609913 1.545336622547791e-07 6.810976903041023 0.38218554258848014 YGVIIVGNPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGVIIVGNPK 10 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 19686100.0 5816200.0 9193100.0 4676800.0 False True 8823600.62117611 7552519.4789818525 3752428.430085739 1.0 0.8559452997970307 0.4252717899629474 23.072936061648733 -6.9515282022379425 0.5418055903120624 1.006266405687965 0.25500049207024555 0.9993158253588933 0.006386526273877428 0.08287781149513519 0.03346702136217867 0.007007164607370702 0.03567630840497116 1.1180772164695515e-07 6.9515282022379425 -0.7512659136177195 down YGVIIVGNPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGVIIVGNPK 10 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 26728000.0 9926600.0 7673100.0 9128300.0 False True 13596732.276278336 7334077.070451477 6972383.54323973 1.0 0.5393999765110432 0.5127984725715431 23.69675663221187 -13.999999999999998 0.4059738444875406 9.068611308635557 0.511453207611439 0.9998460427141385 0.002775191143665603 27.672651489580513 0.21071139550511633 197.11429283249547 0.006696636513468393 1.0000000000000041e-14 13.999999999999998 -8.557158101024118 YGVIIVGNPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGVIIVGNPK 10 0 Q92900-2;Q92900 Q92900-2 UPF1 Regulator of nonsense transcripts 1 0 21860300.0 5816200.0 9807400.0 6236700.0 False True 7529185.554442127 9261609.568602536 5101684.593945988 1.0 1.2300944772357616 0.6775878422781143 22.844062383741182 -6.793598714406077 1.481972576862804 1.1280006666256697 0.6711191421992413 0.812759372669081 0.09805582352668678 0.23002832595867187 0.9979201559475921 0.052070517192262446 0.12159554553563551 1.6084267436398413e-07 6.793598714406077 -0.4568815244264284 YGVSGYPTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGVSGYPTLK 10 0 H7BZJ3;P30101 H7BZJ3;P30101 PDIA3 Protein disulfide-isomerase A3 0 27960600.0 3587600.0 12445000.0 11928000.0 False True 4703378.342367819 10588254.510230059 10693804.981455322 1.0 2.251201953041188 2.2736433693045726 22.165265957378814 -10.852354796346779 0.7022693505197546 7.530941835552681e-15 2.2697081766106266 0.9999644781400453 0.0035472945918800336 2.6262576593189455 0.3584457088460101 4.3707174387632906 0.0034905097885988647 1.404899324395706e-11 10.852354796346779 2.269708176610619 YGVSGYPTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGVSGYPTLK 10 0 H7BZJ3;P30101 H7BZJ3;P30101 PDIA3 Protein disulfide-isomerase A3 0 22363800.0 5600900.0 3906900.0 12856000.0 False True 5423102.495277663 5466945.544214344 9488627.92826704 1.0 1.0080844957245154 1.7496678214231727 22.370687006509574 -6.909283008925308 0.9006067829501662 0.9765149866151085 1.8440485688454993 0.9906480377577588 0.033992652109516804 0.10489415490427631 0.14135463440899945 0.027731912691625376 0.07617732709137832 1.232301539597049e-07 6.909283008925308 0.8675335822303908 YGVSGYPTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGVSGYPTLK 10 0 H7BZJ3;P30101 H7BZJ3;P30101 PDIA3 Protein disulfide-isomerase A3 0 25923600.0 3587600.0 11988000.0 10348000.0 False True 4914032.671244553 11458330.520985298 7904015.523749753 1.0 2.331757089861452 1.6084580735495886 22.228476018901706 -10.219404211299784 4.872952630854568 0.9998475899531561 1.970107581707277 0.705754002131866 0.29528558690957607 0.0004890092593269389 7.833283183049417e-05 0.2859530984797459 0.09530301337212525 6.033867772241155e-11 10.219404211299784 0.9702599917541209 YGVSGYPTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGVSGYPTLK 10 0 H7BZJ3;P30101 H7BZJ3;P30101 PDIA3 Protein disulfide-isomerase A3 0 9372200.0 5600900.0 2075800.0 1695500.0 False True 4657396.51194065 2064617.253385962 2050021.2108937458 1.0 0.443298578528302 0.44016462966764675 22.15109228194385 YGWLAAPQAYVSEK(ub)HEGNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGWLAAPQAYVSEKHEGNK 19 1 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 1 3832750.0 946030.0 848720.0 2038000.0 True False 1295802.8564994656 811220.7440582779 1556666.3739275187 1.0 0.6260371629753484 1.2013142015543632 20.305414812558173 -6.731257135659167 1.7185760198934201 0.7752648879146373 1.2010547769686837 0.5650865493854234 0.1571904836243103 0.3339012002495712 1.9325682203944885 0.0724647333034412 0.17956579382248591 1.8567048178613402e-07 6.731257135659167 0.42578988905404636 YGYEK(ub)PEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 YGYEKPEER 9 1 P62253;I3L2H7;K7EPR7 P62253 UBE2G1 Ubiquitin-conjugating enzyme E2 G1;Ubiquitin-conjugating enzyme E2 G1, N-terminally processed 1 5935300.0 2018400.0 1746100.0 2170800.0 True False 2646141.9462134074 1485588.6862444924 1946186.4397839706 1.0 0.5614168538352031 0.7354807411480463 21.3354590230819 -10.12549061442305 5.210858941223515 1.0000097508738257 0.6484487974912794 0.8446901872235789 0.07106128442816859 8.050081766168525e-06 1.3510063180994945e-06 0.06880670091120995 0.02293493092902686 7.490475460694541e-11 10.12549061442305 -0.35156095338254634 YGYEK(ub)PEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGYEKPEER 9 1 P62253;I3L2H7;K7EPR7 P62253 UBE2G1 Ubiquitin-conjugating enzyme E2 G1;Ubiquitin-conjugating enzyme E2 G1, N-terminally processed 1 4767800.0 1830600.0 2937200.0 0.0 True False 1772488.605019777 4110039.277295649 0.0 1.0 2.3187958814831364 0.0 20.75734492201644 -6.754926858327292 1.6477262720199903 1.7731108640482633 1.813639622046565e-07 0.6592296890483436 0.554346905396437 0.2939140452048723 1.5741938188295357 0.2663517391248809 0.639258393774077 1.7582196994646487e-07 6.754926858327292 -1.773110682684301 YGYEK(ub)PEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGYEKPEER 9 1 P62253;I3L2H7;K7EPR7 P62253 UBE2G1 Ubiquitin-conjugating enzyme E2 G1;Ubiquitin-conjugating enzyme E2 G1, N-terminally processed 1 5846200.0 2018400.0 1548800.0 2279000.0 True False 2764657.02520906 1480368.8948033056 1740747.1374783232 1.0 0.5354620415135805 0.6296430702273784 21.39866908460479 -9.946939423023125 5.746717819903377 1.0000003706464304 0.5825525558701926 0.9632282962794345 0.03844924396764012 1.8259274566288425e-07 3.349684642882209e-08 0.0372283531188107 0.01240944012991706 1.1299535137148649e-10 9.946939423023125 -0.4174478147762378 YGYEK(ub)PEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGYEKPEER 9 1 P62253;I3L2H7;K7EPR7 P62253 UBE2G1 Ubiquitin-conjugating enzyme E2 G1;Ubiquitin-conjugating enzyme E2 G1, N-terminally processed 1 8173000.0 1830600.0 4429100.0 1913300.0 True False 1522225.0093303819 4405239.559192481 2313362.183900324 1.0 2.8939476964251964 1.5197241995898878 20.537750197450716 -6.563450143865902 2.3326805073314705 2.302304265719035 1.5221458557998246 0.0 0.8262227463552576 0.7505130440086897 7.6577266474468795 0.30061941197574077 0.928222966974173 2.7324351039353003e-07 6.563450143865902 -0.7801584099192105 YGYKPSPPNGCGSPLFGVHLNIGIPSLTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGYKPSPPNGCGSPLFGVHLNIGIPSLTK 29 1 A0A2R8Y3M9;Q9BZM1 A0A2R8Y3M9 PLA2G12A Group XIIA secretory phospholipase A2 0 295695000.0 87325000.0 103590000.0 104780000.0 False True 132478409.31264478 85103555.14763576 84070187.07329455 1.0 0.6423956597093049 0.634595384330828 26.981182014505475 YGYKPSPPNGCGSPLFGVHLNIGIPSLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGYKPSPPNGCGSPLFGVHLNIGIPSLTK 29 1 A0A2R8Y3M9;Q9BZM1 A0A2R8Y3M9 PLA2G12A Group XIIA secretory phospholipase A2 0 243130000.0 87325000.0 78748000.0 77057000.0 False True 113043933.93309367 74365604.57494459 63033416.6715884 1.0 0.6578469271863691 0.5576010536655195 26.752308336597924 -13.999999999999998 0.17210345586978298 2.735194983936611 0.4711241804976857 0.999509822351494 0.004193196837200017 12.112701834012276 0.13141023700677987 7.018401434865573 0.08019026180727962 1.0000000000000041e-14 13.999999999999998 -2.2640708034389254 YGYTHLSAGELLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YGYTHLSAGELLR 13 0 P30085;P30085-3;Q5T0D2 P30085 CMPK1 UMP-CMP kinase 0 48735200.0 17393000.0 5926200.0 25416000.0 False True 16840868.73544684 8292562.564724739 18758787.136343732 1.0 0.49240705423173714 1.1138847663398763 24.00546322589341 -6.6895878614234245 1.8680862853585198 0.6816472909223951 1.1117151176060422 0.3684422818228039 0.21469403872809928 0.4175334874745971 2.8247661553473673 0.09195584436429155 0.23956569423136823 2.0436764412582915e-07 6.6895878614234245 0.4300678266836472 YGYTHLSAGELLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YGYTHLSAGELLR 13 0 P30085;P30085-3;Q5T0D2 P30085 CMPK1 UMP-CMP kinase 0 10054000.0 10054000.0 0.0 0.0 False True 15252653.045855489 0.0 0.0 1.0 0.0 0.0 23.862556871031252 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 YGYTHLSAGELLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YGYTHLSAGELLR 13 0 P30085;P30085-3;Q5T0D2 P30085 CMPK1 UMP-CMP kinase 0 60045000.0 15707000.0 19542000.0 24796000.0 False True 21514302.36571474 18678569.823247805 18939695.489650052 1.0 0.868193144529475 0.880330450306974 24.358792723654545 -10.534491593153692 6.214263189320867 1.0001609442594344 0.8742617974182245 0.9930601910193888 0.0049550343345011105 1.106284535312328e-05 8.287076834544776e-07 0.004803807165079491 0.0015992304547840668 2.920844299842073e-11 10.534491593153692 -0.12589914684120984 YGYTHLSAGELLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YGYTHLSAGELLR 13 0 P30085;P30085-3;Q5T0D2 P30085 CMPK1 UMP-CMP kinase 0 33179000.0 17393000.0 9097300.0 6688700.0 False True 14463050.140545906 9048291.039227335 8087276.244945434 1.0 0.6256143034352923 0.5591680984547966 23.785868501327688 -13.999999999999998 0.24318640799373442 3.516891001062262 0.530664362336079 0.9995303637781335 0.004205357594288275 13.738051810573305 0.15606493100770372 16.822950717475003 0.031871150904775866 1.0000000000000041e-14 13.999999999999998 -2.986226638726183 YGYTHLSAGELLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YGYTHLSAGELLR 13 0 P30085;P30085-3;Q5T0D2 P30085 CMPK1 UMP-CMP kinase 0 59527000.0 10054000.0 30860000.0 18613000.0 False True 13015101.193968778 29142613.871879812 15225624.985507812 1.0 2.2391384774929413 1.1698429968845263 23.6336831931237 -6.610253720311001 2.1517079162310777 1.8276667481978488 1.1735739318951626 0.051537336364726793 0.5341822204520167 0.6118958675977767 5.368294733508017 0.204929602549121 0.593383158390644 2.4532752626125435e-07 6.610253720311001 -0.6540928163026862 YHFFLYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YHFFLYK 7 0 D6RG15;Q6IBS0;H0Y858;Q12792;F8VS81;Q12792-4;Q12792-3 D6RG15;H0Y858;Q12792 TWF2;TWF1 Twinfilin-2;Twinfilin-1 0 122890000.0 40851000.0 33795000.0 48244000.0 False True 53556056.60164668 28752917.73187826 43252173.6691256 1.0 0.5368751838049667 0.8076056456291768 25.674546401373163 -10.239291922009548 5.682374768065312 1.0000155929042904 0.6722404147170652 0.66150212142671 0.11052524821625116 2.183442349535897e-05 2.9227808845983067e-06 0.10702069880050108 0.035671870473078134 5.763789055084388e-11 10.239291922009548 -0.32777517818722524 YHFFLYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YHFFLYK 7 0 D6RG15;Q6IBS0;H0Y858;Q12792;F8VS81;Q12792-4;Q12792-3 D6RG15;H0Y858;Q12792 TWF2;TWF1 Twinfilin-2;Twinfilin-1 0 140058000.0 47118000.0 18734000.0 74206000.0 False True 45622264.88108918 26214583.896519355 54769222.467718095 1.0 0.5746006684421651 1.2004932813061722 25.4432347340884 -6.72373028532178 1.7462813983113614 0.7422187863969077 1.1997006861128108 0.5298551571977113 0.17893310923386546 0.3481352682727363 2.076790438051763 0.08130364628868006 0.20318259946849196 1.8891642332937649e-07 6.72373028532178 0.45748189971590303 YHFFLYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YHFFLYK 7 0 D6RG15;Q6IBS0;H0Y858;Q12792;F8VS81;Q12792-4;Q12792-3 D6RG15;H0Y858;Q12792 TWF2;TWF1 Twinfilin-2;Twinfilin-1 0 94384000.0 24958000.0 28457000.0 40969000.0 False True 37863110.674205385 23378626.014444187 32871459.19264937 1.0 0.6174512764047965 0.86816583760096 25.17428960588964 -10.126069565685121 5.107630817611582 1.0000088418368365 0.742808557002461 0.5838730851843473 0.10235379100418349 1.0305867588854502e-05 1.7632238937010865e-06 0.09910703786841178 0.03303454399815795 7.48049667637795e-11 10.126069565685121 -0.2572002848343755 YHFFLYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YHFFLYK 7 0 D6RG15;Q6IBS0;H0Y858;Q12792;F8VS81;Q12792-4;Q12792-3 D6RG15;H0Y858;Q12792 TWF2;TWF1 Twinfilin-2;Twinfilin-1 0 149281000.0 40851000.0 33095000.0 75335000.0 False True 55954718.656765275 31632753.469470173 57542424.57302743 1.0 0.5653277190706699 1.0283748351234037 25.737756462896055 -9.563846405678664 13.499244904622197 0.9999999999050148 0.7968512770970368 0.20422423224733777 0.18903819353275053 0.0 0.0 0.18303544383736936 0.06101181461245644 2.729943094680059e-10 9.563846405678664 -0.2031487228079779 YHFFLYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YHFFLYK 7 0 D6RG15;Q6IBS0;H0Y858;Q12792;F8VS81;Q12792-4;Q12792-3 D6RG15;H0Y858;Q12792 TWF2;TWF1 Twinfilin-2;Twinfilin-1 0 115897000.0 47118000.0 34119000.0 34660000.0 False True 39180704.68132248 33935194.174908735 41907245.75026674 1.0 0.8661200570771181 1.0695888726637428 25.223640009522676 -6.729221156382138 1.72606298296311 0.9193626845383349 1.0694511330045775 0.5556784637423595 0.05628335024254237 0.3376880238085818 1.9706289869357654 0.025844322341032684 0.06418773038322083 1.865429513663358e-07 6.729221156382138 0.15008844846624259 YHFFLYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YHFFLYK 7 0 D6RG15;Q6IBS0;H0Y858;Q12792;F8VS81;Q12792-4;Q12792-3 D6RG15;H0Y858;Q12792 TWF2;TWF1 Twinfilin-2;Twinfilin-1 0 191516000.0 24958000.0 95537000.0 71021000.0 False True 32308622.995730307 90220281.96622753 58095906.73699842 1.0 2.792452094852524 1.798154837631922 24.94541592798209 -10.652757796675365 6.172316757119054 0.9906871650296734 2.2953034662418266 0.693516308890469 0.4059201554732187 0.05148964044570356 0.002896701592473164 0.3890208108947752 0.13101016683647504 2.224550162528389e-11 10.652757796675365 1.3046163012121532 YHFLILLFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YHFLILLFSK 10 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 5930700.0 3002900.0 1273400.0 1654400.0 False True 2907574.583204358 1781875.260693273 1221063.0090638616 1.0 0.6128390552683665 0.41995930770524265 21.471384768568324 -12.744777453574102 0.10261317950115001 2.5095733008067134 1.311048959153871e-24 0.9998212844356579 0.0032243010274242896 7.682570771730707 0.08292974370491772 2.74546214324874 0.33722404670225314 1.799792950518547e-13 12.744777453574102 -2.5095733008067134 YHFLILLFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YHFLILLFSK 10 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 42162100.0 5192100.0 15844000.0 21126000.0 False True 7876795.293354499 13016514.410262989 16950436.84014527 1.0 1.6525139889371978 2.1519458369631654 22.909177351951886 -6.974097024206084 0.12651011225910355 0.18533166843732612 3.6320207691509188 0.9999993068306777 0.00039264825015785726 0.07499425256193411 0.0037870057380072985 0.03266345011512339 0.06947195708712679 1.0614583940131018e-07 6.974097024206084 3.4466891007135927 YHFLILLFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YHFLILLFSK 10 0 Q08945 Q08945 SSRP1 FACT complex subunit SSRP1 0 23743600.0 5192100.0 10864000.0 7687500.0 False True 6721275.801591921 10259408.849776473 6288453.880411074 1.0 1.52640795477349 0.9356042016489884 22.680303674044335 -6.671687776334082 1.9311995036071203 1.3355125365168206 0.9379644734066083 0.2866125553288239 0.22351956976601134 0.45726279034562173 3.289343641463172 0.09312067410538731 0.2482660796876298 2.1296695611172852e-07 6.671687776334082 -0.3975480631102123 YHFNMGLLMGEAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YHFNMGLLMGEAR 13 0 P47897;P47897-2;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9 P47897 QARS Glutamine--tRNA ligase 0 9397900.0 2386500.0 3645500.0 3365900.0 False True 3128724.6108988775 3101605.6100477055 3017628.9559926596 1.0 0.9913322506056611 0.9644917118882188 21.577143248045164 -6.950745151877125 0.5507067334920052 1.0003696588931463 0.9541920803997334 0.9992576341149079 0.0004118101978269297 0.0831899959211729 0.034749586359229416 0.0004465632345558349 0.0022269023289527338 1.1200949730135268e-07 6.950745151877125 -0.046177578493412974 YHFNMGLLMGEAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YHFNMGLLMGEAR 13 0 P47897;P47897-2;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9 P47897 QARS Glutamine--tRNA ligase 0 8214500.0 3696200.0 1952600.0 2565700.0 False True 3578866.154197593 2732283.3626744854 1893666.2006498724 1.0 0.7634494403960415 0.5291246218942339 21.771071158821368 -6.971241866814751 0.2265707152117101 1.0994824693768843 0.18642360406785755 0.9999905143860193 0.0005920304540979077 0.07590178202340364 0.007572281840157983 0.00617602195083402 0.023430920267154032 1.0684596680891739e-07 6.971241866814751 -0.9130588653090268 YHFNMGLLMGEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YHFNMGLLMGEAR 13 0 P47897;P47897-2;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9 P47897 QARS Glutamine--tRNA ligase 0 41408700.0 8313700.0 10568000.0 22527000.0 False True 12612490.7128833 8682057.831839133 18074528.576065145 1.0 0.6883698096975135 1.4330657589783222 23.588349871225457 -6.79303190070042 1.484132042295905 0.8265133822088309 1.4416678832750054 0.8110134799861216 0.13275014898590234 0.23086356124818613 1.0044731685422825 0.07039191628239208 0.1644529464989951 1.6105273310343865e-07 6.79303190070042 0.6151545010661745 YHFNMGLLMGEAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YHFNMGLLMGEAR 13 0 P47897;P47897-2;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9 P47897 QARS Glutamine--tRNA ligase 0 10970200.0 2386500.0 2200500.0 6383200.0 False True 3268853.542737524 2103274.633919599 4875619.626130596 1.0 0.6434288371813064 1.4915381072862244 21.640353309568056 -6.792509303919807 1.4864716583603423 0.8013624985425739 1.5011695860012193 0.8093053756782107 0.1518346204302918 0.23162780777535535 1.011039094395937 0.08039152564572287 0.18786346606335896 1.612466482990134e-07 6.792509303919807 0.6998070874586454 YHFNMGLLMGEAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YHFNMGLLMGEAR 13 0 P47897;P47897-2;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9 P47897 QARS Glutamine--tRNA ligase 0 9910700.0 3696200.0 2901400.0 3313100.0 False True 3073554.06942367 2885769.5823171893 4005853.891956398 1.0 0.9389031450675951 1.303329566187702 21.551476434255644 -6.863787479058959 1.1663673935672227 0.9664517600766335 1.3223042235354274 0.9580847703235781 0.032625233673506754 0.14295566287835484 0.3674076592178418 0.02177950643141792 0.051079720006409396 1.3683982841323877e-07 6.863787479058959 0.35585246345879396 YHFNMGLLMGEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YHFNMGLLMGEAR 13 0 P47897;P47897-2;A0A1B0GVU9;A0A0U1RQT0;C9J165;A0A0U1RQE9;A0A0U1RQM8;A0A0U1RRI9 P47897 QARS Glutamine--tRNA ligase 0 31135700.0 8313700.0 12075000.0 10747000.0 False True 10762248.53752717 11403015.63522192 8791156.273532074 1.0 1.0595384036579756 0.8168512595558407 23.359476193317906 -6.84184358214737 1.2739393650227195 1.031667974515191 0.8085801158506062 0.9275558299461405 0.027796037838312332 0.1666583022175436 0.524619060812469 0.01710414072110983 0.03942326334191266 1.4393168770750063e-07 6.84184358214737 -0.22308785866458491 YHGNVMLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YHGNVMLLR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 97973900.0 24687600.0 29352200.0 43934100.0 False True 32365682.675058518 24972966.17397948 39388220.777645566 1.0 0.7715878087510271 1.2169748178368789 24.94796159853569 -6.767270995309399 1.584654709211418 0.8685376176277013 1.2192416855638817 0.7201441780209423 0.09620038712416623 0.2708432923191651 1.341777844034557 0.04786112799374758 0.11422831443971596 1.708948615884053e-07 6.767270995309399 0.35070406793618036 YHGNVMLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YHGNVMLLR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 23351200.0 9039700.0 2190900.0 12120600.0 False True 8752739.67158161 3065737.7953925673 8945851.249794152 1.0 0.3502603653741015 1.0220629866142983 23.061303231064286 -10.934516094781223 12.898730852942874 1.0448793653875355 0.6861616760085789 0.2253963340042715 0.2742622716504524 0.14582967629700316 0.0007403426082441269 0.10940464205908634 0.08851776754960138 1.1627434593935131e-11 10.934516094781223 -0.35871768937895654 YHGNVMLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YHGNVMLLR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 19552800.0 6709000.0 9135300.0 3708500.0 False True 10178043.493599007 7505034.3405753225 2975513.3495067046 1.0 0.7373749527888395 0.29234629930379163 23.27895692568797 -6.992317060635993 0.39483018994058383 1.0263945694352683 6.631522893857619e-15 0.999869601151189 0.0033353233687286065 0.07506978688806697 0.01723326052223508 0.005674919919268673 0.03572278067307391 1.0178480275297573e-07 6.992317060635993 -1.0263945694352616 down YHGNVMLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 YHGNVMLLR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 69891400.0 28586700.0 23175900.0 18128800.0 False True 39155975.51651985 22151912.105547454 13847150.814355873 1.0 0.5657351608109366 0.35364080786376473 25.222729155385863 -11.27619140164669 0.1292978770710693 2.085067182517463 2.0541552776659295e-12 0.9997518947617893 0.004237440124151841 3.805272162064982 0.08035153263825223 1.440768583174741 0.24696937411768027 5.2943006280308105e-12 11.27619140164669 -2.0850671825154086 YHGNVMLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 YHGNVMLLR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 27808360.0 9846560.0 9690930.0 8270870.0 False True 8187850.916569521 9638723.036590999 10000270.676817905 1.0 1.1771981603970572 1.2213547582529432 22.965053403502314 -13.999999999618868 0.1951395939142539 0.0326341342096986 1.2514455970197433 0.9994873909453114 0.0021656787001564063 12.438889827423152 0.14008403726836532 4.583810303935679 0.029170567648190055 1.0000000008775879e-14 13.999999999618868 1.2188114628100448 YHGNVMLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YHGNVMLLR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 18832900.0 6709000.0 11033500.0 1090400.0 False True 8684932.754161177 10419476.025774019 891958.388448812 1.0 1.1997186760924288 0.10270181862046675 23.05008324778042 -6.859757921410518 1.1869474108209805 1.1082928726580472 0.049822574434280946 0.9533424517267121 0.10305173480926295 0.14705681080750824 0.3938174570522236 0.06772171904124688 0.15804099183811632 1.3811539143194967e-07 6.859757921410518 -1.0584702982237664 down YHGYIFGFYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YHGYIFGFYK 10 0 P07686 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 10455200.0 3120200.0 3207000.0 4128000.0 False True 4090612.416059779 2728528.100788088 3700874.1585720656 1.0 0.6670219085230035 0.9047237386857778 21.963885418229918 -9.967287537234785 5.9274464359331125 1.0000001619287575 0.785872823604337 0.519686857773416 0.09704136580427494 2.0761597073009695e-07 3.6376121765890635e-08 0.09395996981847493 0.031319966137736986 1.0782326107415104e-10 9.967287537234785 -0.21412733832442055 YHGYIFGFYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YHGYIFGFYK 10 0 P07686 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 9678300.0 3339800.0 2287800.0 4050700.0 False True 3233779.8771140953 3201330.470719387 2989700.1516048005 1.0 0.9899654869447493 0.9245218491101759 21.624790047454205 -6.9340992963230725 0.7123658365440522 1.0008600196960873 0.9095686798743547 0.9972839217249639 0.0017441700246319477 0.09056490736203135 0.06766395121645005 0.0016297040564049374 0.005793878836083294 1.1638598961170755e-07 6.9340992963230725 -0.09129133982173254 YHGYIFGFYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YHGYIFGFYK 10 0 P07686 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 11278600.0 3120200.0 3635600.0 4522800.0 False True 4273822.260234488 3474967.170678526 3454607.7899898877 1.0 0.8130818174193019 0.8083180768028352 22.02709547975281 YHGYIFGFYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YHGYIFGFYK 10 0 P07686 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 8502900.0 3339800.0 2625600.0 2537500.0 False True 2777191.6782266027 2611455.371659207 3068079.5179256108 1.0 0.9403223378973872 1.10474172235917 21.40519532288848 -6.808535102658203 1.4209850428016357 0.9674196191110372 1.1075144559919534 0.8558857765028544 0.025798900714232114 0.20881107734463317 0.8313182171344012 0.014277951223519325 0.03304567235722452 1.554049676743386e-07 6.808535102658203 0.14009483688091617 YHGYIFGFYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YHGYIFGFYK 10 0 P07686 P07686 HEXB Beta-hexosaminidase subunit beta;Beta-hexosaminidase subunit beta chain B;Beta-hexosaminidase subunit beta chain A 0 32562300.0 8506300.0 13534000.0 10522000.0 False True 11011573.03424075 12780821.002657853 8607103.964837108 1.0 1.1606716826847157 0.7816416363105536 23.3925172408881 -6.791513144543516 1.490123935130112 1.0896211672943379 0.7774311346448268 0.8062559785840637 0.06837264109703561 0.23309138538925775 1.0224168693266074 0.03611184589610771 0.08446020960635701 1.6161693096911482e-07 6.791513144543516 -0.31219003264951106 YHIDLDPHFNDILGQHSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YHIDLDPHFNDILGQHSR 18 0 H3BV19;H3BSA1;P19784 H3BV19 CSNK2A2 Casein kinase II subunit alpha 0 13798800.0 2973900.0 3242700.0 7582200.0 False True 4073431.1966256523 3099426.791825074 5791440.520310726 1.0 0.7608884604194557 1.4217597501360126 21.957813109495756 -6.808809462911092 1.4194009574600235 0.8695021160577859 1.433024386450578 0.8567353180767687 0.10341187388892463 0.20842360808399127 0.827809887572374 0.05728923463387821 0.13260275708328353 1.5530682348149924e-07 6.808809462911092 0.5635222703927921 YHIDLDPHFNDILGQHSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YHIDLDPHFNDILGQHSR 18 0 H3BV19;H3BSA1;P19784 H3BV19 CSNK2A2 Casein kinase II subunit alpha 0 9692600.0 3257600.0 2803600.0 3631400.0 False True 2708838.7361491607 2788496.450328968 4390708.95030348 1.0 1.02940659150978 1.620882369891549 21.3692430782266 -6.917233533421038 0.8449790134310599 0.9856038361056164 1.7104508154006466 0.9933776593713666 0.023274660685162377 0.09982682129270923 0.11424650699987321 0.01976517805043227 0.057727968618090736 1.2099473329146278e-07 6.917233533421038 0.7248469792950302 YHLK(ub)DVIVGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YHLKDVIVGK 10 1 O75436;S4R3Q6;O75436-2;Q4G0F5 O75436;Q4G0F5 VPS26A;VPS26B Vacuolar protein sorting-associated protein 26A;Vacuolar protein sorting-associated protein 26B 1 9092400.0 2525000.0 2607700.0 3959700.0 True False 2444845.257115124 3648968.208975848 2922535.781546283 1.0 1.4925149959313044 1.1953868135584278 21.221311724130512 -10.432319938001863 5.257162760951036 0.9996434585932861 1.3439509047448728 0.6411485481348878 0.12130207250238474 0.000507426503382151 5.479298796521444e-05 0.11756976873859036 0.039150075555178424 3.695558334312395e-11 10.432319938001863 0.3443074461515867 YHLK(ub)DVIVGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YHLKDVIVGK 10 1 O75436;S4R3Q6;O75436-2;Q4G0F5 O75436;Q4G0F5 VPS26A;VPS26B Vacuolar protein sorting-associated protein 26A;Vacuolar protein sorting-associated protein 26B 1 11674400.0 4491600.0 3001400.0 4181400.0 True False 6814085.579944748 2465776.7199547677 3354944.4572272715 1.0 0.3618646538887117 0.49235431781214506 22.70008863606964 -9.819442206562353 6.491817515006168 1.0000000124195574 0.42710948585207864 0.9625465380317335 0.053272182220306705 9.54946993931816e-09 1.7759519134751682e-09 0.05158056940729248 0.017193522879561315 1.5155064652545483e-10 9.819442206562353 -0.5728905265674787 YHLK(ub)DVIVGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YHLKDVIVGK 10 1 O75436;S4R3Q6;O75436-2;Q4G0F5 O75436;Q4G0F5 VPS26A;VPS26B Vacuolar protein sorting-associated protein 26A;Vacuolar protein sorting-associated protein 26B 1 8932100.0 2525000.0 4276300.0 2130800.0 True False 2099649.3764663073 4253262.723120905 2576340.4282939467 1.0 2.0257014198623544 1.2270336453174417 21.00171699956479 -10.172283694639276 4.73349921669388 0.9999285354889906 1.626367532501797 0.45057854291107236 0.3260547536288548 0.000260350318105548 4.552658572819127e-05 0.3157390650561985 0.1052337192264499 6.725371905902296e-11 10.172283694639276 0.6264389970128064 YHLK(ub)DVIVGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YHLKDVIVGK 10 1 O75436;S4R3Q6;O75436-2;Q4G0F5 O75436;Q4G0F5 VPS26A;VPS26B Vacuolar protein sorting-associated protein 26A;Vacuolar protein sorting-associated protein 26B 1 12474700.0 4491600.0 4870700.0 3112400.0 True False 5814464.742672584 4599641.263310592 2545975.1359208333 1.0 0.7910687340751497 0.43786921902472337 22.47121495816209 -6.963194371455775 0.38779497143002034 1.02223232354703 0.1940595202501105 0.999870950027235 0.0026354554219459613 0.07857914580955046 0.017054413602904096 0.004566370943228515 0.029738729780534927 1.0884428442913408e-07 6.963194371455775 -0.8281728032969196 down YHNVGLSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YHNVGLSK 8 0 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 0 20143400.0 7013400.0 3326500.0 9803500.0 False True 6790763.455941069 4654788.797468331 7235669.251304133 1.0 0.6854588335566265 1.0655163146602944 22.695142348828508 -6.686937367546879 1.8771942577610075 0.802237179623815 1.0641589658167538 0.35611682842709436 0.13311314134443875 0.42331891475407474 2.8896903590391667 0.05677727711192444 0.14843097483693746 2.0561871108196835e-07 6.686937367546879 0.2619217861929388 YHNVGLSK(ub)CEIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YHNVGLSKCEIK 12 1 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 6411300.0 2025000.0 3355700.0 1030600.0 True False 2654794.6101278956 2855042.6404161467 923963.3982132667 1.0 1.075428822073209 0.34803573680931743 21.34016881965231 -6.881310309057885 1.0725037894480098 1.0476061377752752 0.295181015858627 0.974725427038043 0.0519184596935481 0.1264739366759691 0.26534737625083804 0.037246296710711904 0.09037550886003222 1.3142854225875275e-07 6.881310309057885 -0.7524251219166482 down YHNVGLSK(ub)CEIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YHNVGLSKCEIK 12 1 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 5029200.0 2025000.0 1846500.0 1157700.0 True False 2773697.2235673503 1764915.5244410508 884275.1035799262 1.0 0.6363043195360488 0.31880736515380315 21.4033788811752 -7.554002790309974 0.25502639696819696 1.1316411284153343 5.481565846407711e-13 0.9998304268312151 0.0036241403717571295 0.12835435959043268 0.0274779595538076 0.029627351599105373 0.06924986060588018 2.792525899407025e-08 7.554002790309974 -1.131641128414786 down YHNVGLSK(ub)CEIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YHNVGLSKCEIK 12 1 Q14103-3;Q14103;H0YA96;H0Y8G5;Q14103-4;Q14103-2 Q14103-3;Q14103-4 HNRNPD Heterogeneous nuclear ribonucleoprotein D0 1 8688800.0 2967000.0 3555100.0 2166700.0 True False 3840839.9883136414 3357255.5598159404 1772382.8322194044 1.0 0.8740940966119176 0.4614570868904087 21.8729904309086 -6.94944806016939 0.5648741697532883 1.0052653158862832 0.3103997012068006 0.9991572282817673 0.0066773706637281395 0.08370820598444191 0.0368859979863585 0.007116343046103809 0.03433879275708702 1.123445321071691e-07 6.94944806016939 -0.6948656146794826 down YHPDK(ub)NKEPGAEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YHPDKNKEPGAEEK 14 2 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 33216500.0 11424900.0 9872600.0 11919000.0 True False 14978154.538888969 8399646.563093381 10685736.215121215 1.0 0.5607931565457356 0.713421415660854 23.83635654424278 -10.251467519860492 5.544412496144957 1.000025680614522 0.637107286103281 0.882869217160061 0.06231022586027135 1.9781192422831682e-05 2.6706182207573143e-06 0.06033587887442092 0.02011053892126405 5.6044433046720144e-11 10.251467519860492 -0.36291839451124097 YHPDK(ub)NKEPGAEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YHPDKNKEPGAEEK 14 2 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 75816300.0 14539800.0 19957500.0 41319000.0 True False 14078242.007684147 27926633.826987613 30496314.356570147 1.0 1.9836733742568693 2.1662018837241703 23.746963855775967 -10.75619863632917 0.33084978983099733 1.55526621640702e-09 2.2065219817004507 0.9992201288297881 0.014303231339618843 2.4241726480798125 0.16301635150881535 1.987022178469611 0.058039014104302324 1.753078500573413e-11 10.75619863632917 2.2065219801451845 YHPDK(ub)NKEPGAEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YHPDKNKEPGAEEK 14 2 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 218905000.0 41015000.0 41669000.0 136221000.0 True False 62222753.59814616 34232841.388616994 109296859.6422146 1.0 0.550165966773237 1.7565416720077611 25.890938905346886 -6.80572134868476 1.4324041853119645 0.7535767805277431 1.7756512600319139 0.8483725464069529 0.19383169819683532 0.21269215491503735 0.8608547813462943 0.10642605506463558 0.24670097676416092 1.5641509086976207e-07 6.80572134868476 1.0220744795041707 YHPDK(ub)NKEPGAEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YHPDKNKEPGAEEK 14 2 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 46080200.0 11424900.0 14149700.0 20505600.0 True False 15648994.276313376 13524519.467199318 15662599.606088415 1.0 0.8642420866413311 1.0008694060164385 23.89956660576567 -10.907940877846425 8.2245407456469 1.0117977972061225 0.9325557463249576 0.24522768787970306 0.05577786956554783 0.013519581527511293 0.0001513275529856281 0.060511021961508184 0.018002229992858023 1.2361156991052942e-11 10.907940877846425 -0.07924205088116487 YHPDK(ub)NKEPGAEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YHPDKNKEPGAEEK 14 2 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 49137100.0 14539800.0 23045500.0 11551800.0 True False 12090487.92235438 22921349.317326386 13967227.97051155 1.0 1.8958167333302223 1.1552245087385782 23.527369131210243 -10.31248912004786 4.870808062690468 0.999764573028278 1.525520621034739 0.4016873469206851 0.30234550962153756 0.0007733106915490194 0.00010915181215851821 0.29287384992302096 0.09758159363023412 4.869797248367168e-11 10.31248912004786 0.5257560480064609 YHPDK(ub)NKEPGAEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YHPDKNKEPGAEEK 14 2 P25685 P25685 DNAJB1 DnaJ homolog subfamily B member 1 1 193181000.0 41015000.0 42178000.0 109988000.0 True False 53094726.02651963 39830757.22255824 89971312.57218249 1.0 0.7501829315902989 1.6945433060007473 25.662065227439335 -6.836355103622202 1.2990980112778252 0.8669739451346403 1.7234507363108749 0.9180224188559407 0.11439224065199845 0.17309976772892552 0.5690195946158156 0.06908313149393835 0.15904249941183546 1.4576219391156525e-07 6.836355103622202 0.8564767911762345 YHPDK(ub)NPEGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YHPDKNPEGR 10 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 11692100.0 2720400.0 5364400.0 3607300.0 True False 3566470.744391072 4564052.430267427 3234051.199664974 1.0 1.2797111647264274 0.9067931384972417 21.766065708567538 -6.70595192884161 1.8093628728234628 1.1726627588810983 0.90775874056542 0.4459988705972522 0.11794573605633817 0.38326243308479074 2.443191211443639 0.051922108486788146 0.13257156704786588 1.9681041230276037e-07 6.70595192884161 -0.2649040183156782 YHPDK(ub)NPEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YHPDKNPEGR 10 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 13058700.0 4095000.0 4898000.0 4065700.0 True False 3965006.4664896755 6853796.9427325735 3000771.201614449 1.0 1.72857144134759 0.7568136967683461 21.918891788132363 -6.7060555165250175 1.8092750452111093 1.4496998373543708 0.7593504215310243 0.44637416316502376 0.30721164973817466 0.38304519905436335 2.4417000772614794 0.13525249569940972 0.34525725810246594 1.9676347478833277e-07 6.7060555165250175 -0.6903494158233465 YHPDK(ub)NPEGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YHPDKNPEGR 10 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 10465800.0 2720400.0 3993800.0 3751600.0 True False 3726205.3960457356 3817340.7102695275 2865549.3466273267 1.0 1.024457941669159 0.7690261384056444 21.82927577009043 -6.883418176538163 1.0605840243188613 1.015967323098105 0.749696529472143 0.976338355419272 0.017702136700523237 0.12464389849075233 0.25437170043108187 0.012815578195638385 0.031277948794536395 1.307921935372863e-07 6.883418176538163 -0.26627079362596195 YHPDK(ub)NPEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YHPDKNPEGR 10 1 O75165 O75165 DNAJC13 DnaJ homolog subfamily C member 13 1 10481700.0 4095000.0 4513800.0 1872900.0 True False 3405173.939259218 4489483.26348085 2264514.730688818 1.0 1.3184299373727495 0.6650217495736661 21.69929706356664 -6.774151566615856 1.5582534376564696 1.1816670520812782 0.6607264468789814 0.7463217779687155 0.1343683429727978 0.2597524842706963 1.2452212060883912 0.06794225439404673 0.16114329214071782 1.6820869186464494e-07 6.774151566615856 -0.5209406052022968 YHPDK(ub)NPNEGEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YHPDKNPNEGEK 12 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 222487000.0 56510000.0 71208000.0 94769000.0 True False 85729801.4343837 58500376.04935657 76037865.61127174 1.0 0.6823808648866623 0.8869478797226653 26.353293466074014 -10.63245947879871 6.100279027467443 1.0012331507102439 0.7846643723046638 0.5963516814163591 0.08351413409209395 0.0014082431164383286 8.484622634135239e-05 0.0813009475716986 0.026954070875967743 2.330990594750367e-11 10.63245947879871 -0.2165687784055801 YHPDK(ub)NPNEGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YHPDKNPNEGEK 12 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 150641000.0 33413000.0 38176000.0 79052000.0 True False 45766689.052373305 36489258.08885004 60381545.72704532 1.0 0.7972885704511726 1.3193339299232996 25.4477945895235 -6.801393610048517 1.450098506527547 0.8883534707033652 1.3268014411171984 0.8362513428592285 0.08695690019914579 0.21876547185584191 0.9080182137896897 0.04717101325864913 0.10961636249835303 1.5798155707869052e-07 6.801393610048517 0.4384479704138332 YHPDK(ub)NPNEGEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YHPDKNPNEGEK 12 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 144514000.0 41152000.0 56306000.0 47056000.0 True False 34219711.34270946 56002668.40213407 56895192.037638426 1.0 1.6365616834481418 1.6626438331941102 25.028324254366215 -11.34078830096748 0.5280916731168912 1.2629807182765903e-19 1.660810202179677 0.9998804900935225 0.003349695268755691 3.7613355733912583 0.2594130349619865 4.3778490910785 0.005048260210230493 4.5625926763161855e-12 11.34078830096748 1.660810202179677 YHPDK(ub)NPNEGEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YHPDKNPNEGEK 12 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 166455000.0 56510000.0 56335000.0 53610000.0 True False 73153308.97863296 53199907.72755508 43853530.08505209 1.0 0.7272385688403243 0.5994743190340314 26.124419788166463 -13.99999999978991 0.10122407202812163 2.3423438776598027 0.3324411662376225 0.9997875704445575 0.0024347020012641467 12.071260641470252 0.09499532344867588 3.374540988624628 0.23799745171263356 1.0000000004837495e-14 13.99999999978991 -2.00990271142218 YHPDK(ub)NPNEGEKFK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YHPDKNPNEGEKFK 14 2 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 2 8270100.0 2117500.0 2826800.0 3325800.0 True False 2741145.4921651958 2669486.0950430906 2720538.525589745 1.0 0.9738578644121869 0.992482352128207 21.386347473647895 -10.00916809934511 4.585032704340973 1.000000482041744 0.9831701082689612 0.5212472284494892 0.007603415275046568 3.7469417154397384e-08 8.087487107285682e-09 0.007362186035133521 0.002453991727285297 9.791109343942828e-11 10.00916809934511 -0.016830373772782847 YHPDKNPNEGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YHPDKNPNEGEK 12 1 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 0 10675400.0 3776600.0 1488000.0 5410800.0 False True 3656713.9002063205 2082166.1598174917 3993549.1594794136 1.0 0.5694090969763893 1.0921141955497498 21.802116324551445 -6.687868377511442 1.8738901165303221 0.7295066996078062 1.0902661974002104 0.3604599969816208 0.18218982717531684 0.42129555732542445 2.8665072692742903 0.07782572125988146 0.2032172965752223 2.0517839228203537e-07 6.687868377511442 0.3607594977924041 YHPDKNPNEGEKFK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 YHPDKNPNEGEKFK 14 2 P31689;P31689-2 P31689 DNAJA1 DnaJ homolog subfamily A member 1 1 91648000.0 12861000.0 17725000.0 61062000.0 True False 12452734.594755473 24802684.93465391 45068030.3792659 1.0 1.991746049506241 3.6191271914079426 23.56995925414212 -6.963722038034381 0.37934622849542876 0.8873896808050198 4.780972282503982 0.9998843300807723 0.011612160138408087 0.07839734061390871 0.01640573981751718 0.02119324750386279 0.13755545774219302 1.0871211923496682e-07 6.963722038034381 3.8935826016989625 YHPGYFGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YHPGYFGK 8 0 E9PLL6;P46776 E9PLL6 RPL27A 60S ribosomal protein L27a 0 22072400.0 3332900.0 7024500.0 11715000.0 False True 4565163.198235861 6714134.3630848555 8948158.277998488 1.0 1.4707326050642466 1.9600960336875515 22.122235004797 -6.97063741707777 0.24248479345134796 0.8296099962693542 2.6154163616763157 0.9999869345165543 0.0014168551120455094 0.07609646401236739 0.008286890393273995 0.011494744853899478 0.04749951949490881 1.0699477823367375e-07 6.97063741707777 1.7858063654069616 YHPGYFGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YHPGYFGK 8 0 E9PLL6;P46776 E9PLL6 RPL27A 60S ribosomal protein L27a 0 17901500.0 4776100.0 3772400.0 9353000.0 False True 6182755.601005991 3562462.6237938832 7650849.969884204 1.0 0.5761933438245946 1.237449846576394 22.5598185475595 -6.733621045478465 1.7101182407098436 0.7459857091973711 1.2373164061733744 0.5759118407608305 0.17811336439223663 0.32950065024022235 1.8894306133001468 0.08248423867653494 0.2038382291043954 1.8466260361581803e-07 6.733621045478465 0.4913306969760033 YHQCATIQLDFQLPIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YHQCATIQLDFQLPIR 16 0 P26639;P26639-2;A2RTX5-2;A2RTX5;B7ZLP8 P26639 TARS;TARSL2 Threonine--tRNA ligase, cytoplasmic;Probable threonine--tRNA ligase 2, cytoplasmic 0 26920000.0 14023000.0 12897000.0 0.0 False True 21273916.218622543 10595429.585279077 0.0 1.0 0.4980479135291582 0.0 24.342582301135923 -7.934748792777265 0.5917389982143709 1.0108740857471084 1.8721574668672256e-18 0.9890473319114643 0.04272533116635762 0.11230339247515299 0.16185157311678344 0.04496899413142528 0.07693922892491901 1.1621206202578522e-08 7.934748792777265 -1.0108740857471084 YHSDDYIK(ub)FLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YHSDDYIKFLR 11 1 Q13547;Q5TEE2 Q13547 HDAC1 Histone deacetylase 1 1 5858800.0 2159500.0 2239900.0 1459400.0 True False 2831125.41262775 1905715.6510618168 1308395.28755331 1.0 0.6731300713708049 0.46214670735440994 21.432944228199982 -8.561652041565697 0.13202926626748776 1.4762142956696218 8.992975245073871e-14 0.9999348168780252 0.001786438349268521 0.18099698511669657 0.03361230140439649 0.18720022509870715 0.15864234472450886 2.743771612038256e-09 8.561652041565697 -1.4762142956695319 YHSDDYIK(ub)FLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YHSDDYIKFLR 11 1 Q13547;Q5TEE2 Q13547 HDAC1 Histone deacetylase 1 1 29738800.0 4236500.0 7152300.0 18350000.0 True False 6427080.229636629 5875916.183825044 14723114.456909295 1.0 0.9142434782018045 2.290793631144963 22.615732051061777 -6.892059519513063 1.0100935126085393 0.9296468772274741 2.414091702091903 0.9821849872660046 0.08404427480380615 0.1174890597045598 0.21220155376297847 0.06321858677491336 0.15882369418122688 1.2821548529029346e-07 6.892059519513063 1.4844448248644286 up YHSDDYIK(ub)FLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YHSDDYIKFLR 11 1 Q13547;Q5TEE2 Q13547 HDAC1 Histone deacetylase 1 1 38915600.0 4236500.0 7797100.0 26882000.0 True False 5484232.763899805 7363184.53079825 21989751.832612727 1.0 1.3426097774818613 4.0096313886166906 22.386858373154226 -6.9306078655086685 0.7417856666910204 0.9603440980725642 4.5657300971251 0.9966563813271582 0.07779013992035566 0.09232336690574396 0.07614286371735639 0.07112858625616295 0.24051775036161643 1.1732542457159607e-07 6.9306078655086685 3.605385999052536 up YHSDEYIK(ub)FLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YHSDEYIKFLR 11 1 Q92769-3;Q92769;H3BM24;E5RJ04;E5RGV4;E5RHE7;E5RH52;E5RG37;E5RFP9;E5RFI6;E5RK19 Q92769-3 HDAC2 Histone deacetylase 2 1 24635400.0 6117300.0 5874100.0 12644000.0 True False 7918965.440010462 5547201.1712511135 10342921.738395795 1.0 0.700495691422513 1.3060950722348563 22.91688053346008 -6.772202633829896 1.5658159592275982 0.8287014885428048 1.3098075732771597 0.7390211032182883 0.12630515182774332 0.2628638786141207 1.2721745056985063 0.06356756048438413 0.15102626942879094 1.6896523869222716e-07 6.772202633829896 0.4811060847343549 YHTEIVFAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YHTEIVFAR 9 0 P05023-4;P05023;P05023-3 P05023-4 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 0 36684000.0 10854000.0 13044000.0 12786000.0 False True 14229699.11028551 11097886.045113774 11463027.371972488 1.0 0.7799100992298567 0.8055706085652075 23.762401820335356 -10.22881969086976 14.439286636902775 1.000000000002004 0.7927403534281756 0.9886342502970277 0.010475859068588968 0.0 0.0 0.010143206927465247 0.003381068975821748 5.904461690279512e-11 10.22881969086976 -0.20725964657382834 YHTEIVFAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YHTEIVFAR 9 0 P05023-4;P05023;P05023-3 P05023-4 ATP1A1 Sodium/potassium-transporting ATPase subunit alpha-1 0 24766300.0 10854000.0 7859600.0 6052700.0 False True 14867017.118320988 7512336.883778441 4623176.919269434 1.0 0.5053022286845157 0.3109686955006045 23.825611881858247 -13.999999999999863 0.12912025011235193 3.3507198710926915 0.03575265429151649 0.9996496171621225 0.0054296413549090134 11.938167943514317 0.11165623123131888 7.127899329285115 0.24468094165808044 1.0000000000003149e-14 13.999999999999863 -3.314967216801175 YHTINGHNAEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YHTINGHNAEVR 12 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 95448300.0 5111300.0 52625000.0 37712000.0 False True 6700963.797899602 44773555.13064338 33809923.99904787 1.0 6.681659009212604 5.045531511399225 22.675937182275206 -10.138392119361432 6.756231203718461 0.9999926593356 5.8635952603059165 0.9217650291343399 0.667946253963237 7.38546995453138e-05 9.420004722402843e-06 0.646737134582726 0.215578726480103 7.27122997298167e-11 10.138392119361432 4.863602600970316 YHTINGHNAEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YHTINGHNAEVR 12 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 78848000.0 23018000.0 11362000.0 44468000.0 False True 22287306.189416178 15898905.85204725 32820496.788595118 1.0 0.7133614855436115 1.4726094086768078 24.409718916429327 -6.804406065581343 1.4376840242662405 0.8427184519937211 1.4842874556573222 0.8447728526304876 0.12333650328182182 0.214530437474785 0.8748762881240689 0.06747271759083243 0.15652709029386053 1.5688952004530637e-07 6.804406065581343 0.6415690036636011 YHTINGHNAEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YHTINGHNAEVR 12 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 287334000.0 5718000.0 274030000.0 7586000.0 False True 8674624.041794464 225127205.4938376 6086623.7749380795 1.0 25.952387608865983 0.7016585094192714 23.04836980196698 -12.45406553445318 1.6128050253562191e-10 8.599879893766213 15.588760495742891 0.0 12.178159594817751 0.0 0.6473749509619318 871094445.3755089 871094443.8600016 3.515073945330669e-13 12.45406553445318 6.988880601976678 YHTINGHNAEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YHTINGHNAEVR 12 0 P22626;P22626-2;A0A087WUI2 P22626 HNRNPA2B1 Heterogeneous nuclear ribonucleoproteins A2/B1 0 111428300.0 5111300.0 53797000.0 52520000.0 False True 7001085.73768878 51420070.65711098 40115857.683353 1.0 7.3445851948794925 5.729948066111839 22.739147243798097 -10.473531823999283 6.724081728064001 0.9984030902213922 6.537266630495665 0.9400523321830945 0.6591728475388747 0.015775121069150157 0.0012351310689682473 0.6380330443496713 0.2127471217325152 3.3609973960731454e-11 10.473531823999283 5.538863540274273 YHTINGHNCEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YHTINGHNCEVK 12 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 31282600.0 1616600.0 16293000.0 13373000.0 False True 2119378.2551766676 13862147.90961656 11989290.242874065 1.0 6.540667233778444 5.656984643297975 21.015209664427964 -9.773763129747103 6.48790470746784 0.9999999444153949 6.09882593854001 0.9779687833645985 0.36076190688279136 2.939704591425587e-07 5.7763627314859594e-08 0.3493062143226544 0.11643540477430378 1.683592065238282e-10 9.773763129747103 5.098825994124615 YHTINGHNCEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YHTINGHNCEVK 12 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 18208300.0 7904600.0 2745100.0 7558600.0 False True 7653672.799759275 3841232.745507386 5578775.906860555 1.0 0.5018809721821661 0.7289018034630406 22.86772079535609 -10.346318832289356 5.860934909668749 1.0000567330626746 0.6153913878226032 0.7928270183151607 0.09268086627010484 6.871612617840026e-05 7.664138577846931e-06 0.08975104652767601 0.029912620964682314 4.504858641089508e-11 10.346318832289356 -0.38466534524007145 YHTINGHNCEVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YHTINGHNCEVK 12 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 60532400.0 1240800.0 57771400.0 1520200.0 False True 1882384.314630743 47461642.29999154 1219731.8036726716 1.0 25.213577233457677 0.647971720860806 20.844129773484614 -7.95291548737613 1.3045892696993358e-10 8.575170953135427 14.90022326251965 0.0 11.830462001238303 0.0 0.6932702214689084 3.6758990190708616 3.675899019070862 1.1145113936305538e-08 7.95291548737613 6.325052309384223 YHTINGHNCEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YHTINGHNCEVK 12 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 34381600.0 1616600.0 18264000.0 14501000.0 False True 2214300.706972333 17457036.089028664 11076162.457469555 1.0 7.883769369742961 5.002104015318795 21.078419725950855 -9.620097894133428 8.103622397371357 1.00003035373093 6.442936692530924 0.8262934820402152 1.1764349547633015 0.0 1.9447551516768668e-17 1.139078263837656 0.3796927489548609 2.398292260054282e-10 9.620097894133428 5.442906338799993 YHTINGHNCEVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YHTINGHNCEVK 12 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 9393950.0 7904600.0 693340.0 796010.0 False True 6573025.133154669 689604.8398027847 962452.0106656034 1.0 0.10491437744918748 0.14642451400511877 22.648126070790365 -10.126328142611293 4.99837266481541 1.0000373586540885 0.1256694457248369 0.998312340737962 0.016946442294686507 94615503.72766674 2.038141256478562 40902.01419629007 0.005801217945072155 7.476044148888357e-11 10.126328142611293 -0.8743679129292516 YHTINGHNCEVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YHTINGHNCEVK 12 0 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 0 4003200.0 1240800.0 1356900.0 1405500.0 False True 1606240.0598245934 1281387.3221890375 1149713.4216478402 1.0 0.7977557989239598 0.7157793224092497 20.615256095577063 -13.999999999996254 0.1243303484448875 1.9616773721208736 0.5922603820719743 0.9996719840248449 0.0021632882996454384 11.949196513155593 0.10905132689995596 2.8243222716977763 0.10967142395802382 1.0000000000086262e-14 13.999999999996254 -1.3694169900488993 YHTINGHNCEVKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YHTINGHNCEVKK 13 1 P51991;P51991-2 P51991;P51991-2 HNRNPA3 Heterogeneous nuclear ribonucleoprotein A3 1 2540910.0 936590.0 865440.0 738880.0 True False 778816.0829721091 860777.702943611 893376.3918048774 1.0 1.105238735772791 1.1470954585267226 19.57092315123324 -13.999999999546954 0.12723246106004002 0.49990630582387147 1.2078265665268755 0.9996583108892426 0.0011438608727304465 11.941796734597743 0.11064053031594552 1.4974176070545462 0.053960452673716595 1.0000000010431761e-14 13.999999999546954 0.707920260703004 YHTSQSGDEMTSLSEYVSR ddPTM_RPMI8226_Bortezomib_1h_R1 2 YHTSQSGDEMTSLSEYVSR 19 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 323668400.0 38362100.0 137859700.0 147446600.0 False True 50293084.5991049 117291570.13290171 132190240.23965882 1.0 2.3321609932628635 2.6283979456295166 25.583856704392204 -10.310628793839538 0.33150944589218034 7.585181593625908e-24 2.6989849773457557 0.9990118136027717 0.022262976635076002 1.766349979705443 0.155196560764078 1.6516992349950659 0.09363501249735605 4.8907020556509107e-11 10.310628793839538 2.6989849773457557 YHTSQSGDEMTSLSEYVSR ddPTM_RPMI8226_Bortezomib_2h_R1 2 YHTSQSGDEMTSLSEYVSR 19 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 240060100.0 65230000.0 26530300.0 148299800.0 False True 63159309.3550968 37123987.14368679 109455633.4813642 1.0 0.5877832978661438 1.7330087139803627 25.912492059674655 -6.809346598359921 1.417190359586643 0.7751645985615476 1.7527601647653055 0.8581181078978145 0.17839602890863676 0.2077053138305699 0.8222987258356399 0.09898093619270892 0.22904111723161727 1.551148587256803e-07 6.809346598359921 0.9775955662037579 YHTSQSGDEMTSLSEYVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YHTSQSGDEMTSLSEYVSR 19 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 504663600.0 7385600.0 483310000.0 13968000.0 False True 11204495.159684721 397059554.38173455 11207218.677608121 1.0 35.437522951538966 1.0002430736846761 23.417574311094004 -3.5610477775554856 12.24888223891331 9.999999999999998 17.264106192429388 0.0 16.422171990359377 0.0 0.0 5.478375971070344 0.0 0.00027475918687089687 3.5610477775554856 7.26410619242939 YHTSQSGDEMTSLSEYVSR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 YHTSQSGDEMTSLSEYVSR 19 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 283938800.0 38362100.0 125757100.0 119819600.0 False True 52545605.06677192 120200735.49888226 91520678.24212264 1.0 2.287550697078055 1.7417380221585317 25.647066765915095 -9.976474948613046 5.568638214321125 0.9999979738511079 2.014644359619451 0.8216720826331598 0.22282709145348636 76604961.93851197 6.336808454843281 1990.216109834088 0.07627964025708373 1.0556623951810257e-10 9.976474948613046 1.0146463857683434 YHTSQSGDEMTSLSEYVSR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 YHTSQSGDEMTSLSEYVSR 19 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 104722000.0 65230000.0 22463900.0 17028100.0 False True 54241635.17896915 22342882.511964954 20588596.980961252 1.0 0.41191388198834855 0.3795718346806766 25.69289733510893 -13.798771629085026 0.4147100907672312 9.999999999999993 0.3782820896466173 0.9998545720037663 0.0034387847508285667 24.378890335199205 0.2137865438740725 197.26112515436478 0.00795807354593404 1.589382295187673e-14 13.798771629085026 -9.621717910353375 YHTSQSGDEMTSLSEYVSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YHTSQSGDEMTSLSEYVSR 19 0 P08238 P08238 HSP90AB1 Heat shock protein HSP 90-beta 0 40296600.0 7385600.0 21948000.0 10963000.0 False True 9560804.791941091 20726574.506157406 8967846.489879228 1.0 2.167869228292169 0.9379802940269553 23.188700633186453 -6.65785430187372 1.9802927853574197 1.7530528121392566 0.9431003672278901 0.2266316030332739 0.4975053282707478 0.4895362334166038 3.6880647773837794 0.2031223178910425 0.5514613404976513 2.1985973396406145e-07 6.65785430187372 -0.8099524449113664 YHTVNGHNCEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YHTVNGHNCEVR 12 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 123550900.0 6218900.0 65270000.0 52062000.0 False True 8153038.123913274 55531970.42046727 46675123.65396772 1.0 6.811199650543665 5.724874941657297 22.958906330453374 -10.380665628496208 5.7420039628778685 0.9985363801199472 6.268037296100493 0.9690935860968063 0.4434902052915597 0.008308714513553531 0.0008961768366365951 0.4293641968788139 0.1431358482750199 4.162309512112133e-11 10.380665628496208 5.2695009159805455 YHTVNGHNCEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YHTVNGHNCEVR 12 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 58788000.0 26651000.0 8337000.0 23800000.0 False True 25804978.593019865 11666007.576880658 17566066.015304606 1.0 0.4520835983191345 0.6807239134876147 24.6211460980206 -10.283443625561361 5.671666386236123 1.0000374125068057 0.5664037559033716 0.8274425507009339 0.0933420177986707 4.4161483484829795e-05 5.579375263654502e-06 0.09038579621588824 0.030126006702967785 5.2066259003384177e-11 10.283443625561361 -0.4336336566034341 YHTVNGHNCEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YHTVNGHNCEVR 12 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 262558800.0 4974900.0 252320000.0 5263900.0 False True 7547287.013907536 207291524.61484185 4223487.85775067 1.0 27.465700487189853 0.5596034508781719 22.847526708467512 -12.879065777111862 1.2440077520320511e-18 8.86982708460213 16.55294645988891 0.0 12.942336100534343 0.0 0.6246206264907079 15.58702132734976 15.587021746324739 1.321095529342908e-13 12.879065777111862 7.683119375286781 YHTVNGHNCEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YHTVNGHNCEVR 12 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 138475900.0 6218900.0 66006000.0 66251000.0 False True 8518195.389453337 63089636.66734697 50603878.28217477 1.0 7.406455684904852 5.9406806217228985 23.022116391976265 -10.464006148715178 6.676085484598165 0.9985019872711884 6.673568153313876 0.952327315288996 0.5984001637485934 0.013338710114709223 0.0010709070165495352 0.5792423227534466 0.1931328223805077 3.435530838615249e-11 10.464006148715178 5.675066166042687 YHTVNGHNCEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YHTVNGHNCEVR 12 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 32011800.0 26651000.0 2711100.0 2649700.0 False True 22161487.339486554 2696494.766188781 3203740.0191714275 1.0 0.12167481021836751 0.14456340272176213 24.401551373454875 -10.478382658790363 5.683596546017316 1.000940365986631 0.13311910647008746 0.999477418864391 0.009344228760637743 0.0001114473881335537 1.0228194283565597e-05 0.009055942542876743 0.003015836864424775 3.323665745804906e-11 10.478382658790363 -0.8678212595165435 YHTVNGHNCEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YHTVNGHNCEVR 12 0 P09651;F8W6I7;P09651-3;F8VZ49;F8VTQ5;P09651-2;A0A2R8Y4L2;H0YH80 P09651;P09651-2 HNRNPA1 Heterogeneous nuclear ribonucleoprotein A1;Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed 0 17493500.0 4974900.0 3797300.0 8721300.0 False True 6440106.119939844 3585976.916905033 7134112.888094841 1.0 0.5568195383927197 1.1077632503610793 22.618653030559962 -6.692595890476567 1.8573641577946283 0.7228329151952124 1.1059129854818712 0.3825683603117821 0.18733624900620796 0.4110885256474523 2.7516078891057223 0.08063110890419675 0.2092712683047716 2.0295703494062482e-07 6.692595890476567 0.3830800702866588 YHVLVNLGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YHVLVNLGK 9 0 O75643;A0A494C1A5;O75643-2 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 185792000.0 47229000.0 69846000.0 68717000.0 False True 61917676.366286635 59425249.05757557 61606824.02000887 1.0 0.9597461104004193 0.9949795863714449 25.883847995549537 -10.580822168574798 5.485471127758912 1.0001136138204922 0.9773628483867121 0.355001373887303 0.014384006332270828 2.008646561350883e-05 1.5349133687940185e-06 0.013997144713767897 0.004642418081385573 2.625293307398141e-11 10.580822168574798 -0.022750765433780185 YHVLVNLGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YHVLVNLGK 9 0 O75643;A0A494C1A5;O75643-2 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 154648000.0 37955000.0 31651000.0 85042000.0 False True 36750139.30051664 44289409.35778457 62766948.99468624 1.0 1.205149428023037 1.7079377164103386 25.13124638267166 -6.955885830577993 0.48998732240285314 0.9889955989784242 1.9454115950980218 0.9995858777802614 0.00605222707245671 0.08120486008912267 0.02682091946820739 0.007238895109012132 0.041468482416002095 1.1069147368018236e-07 6.955885830577993 0.9564159961195976 YHVLVNLGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YHVLVNLGK 9 0 O75643;A0A494C1A5;O75643-2 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 190789000.0 50057000.0 59426000.0 81306000.0 False True 75940128.65689155 48820966.00254278 65235833.46231422 1.0 0.6428875861288429 0.8590429673494381 26.178359107367935 -10.312690402665712 5.709436720143831 1.0000296557732562 0.7509652767391387 0.6389642980023778 0.08824506485787893 3.331542430976279e-05 4.010699335625215e-06 0.08545307730234931 0.028480972214962298 4.867540764653063e-11 10.312690402665712 -0.2490643790341175 YHVLVNLGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YHVLVNLGK 9 0 O75643;A0A494C1A5;O75643-2 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 201307000.0 47229000.0 65176000.0 88902000.0 False True 64690837.61573454 62296308.81178993 67905178.5941632 1.0 0.9629850394244672 1.0496877316308986 25.94705805707243 -6.790681526869008 1.4934568619748607 0.9793310864730841 1.0506293495919428 0.8035891110388172 0.015742749920895284 0.23432590162928427 1.032460916680758 0.008296561409664541 0.01941596652499648 1.6192670294807865e-07 6.790681526869008 0.07129826311885867 YHVLVNLGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YHVLVNLGK 9 0 O75643;A0A494C1A5;O75643-2 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 103112000.0 37955000.0 29281000.0 35876000.0 False True 31561264.191595517 29123257.44117657 43377505.728117906 1.0 0.9227531972224304 1.3743906284865783 24.911651658105935 -6.8628401531283965 1.1712132391763446 0.9577253039559915 1.3974870426181567 0.957005235709637 0.04089685289877687 0.14390969266555484 0.373497026852116 0.027200230766949482 0.06371433514976968 1.3713864271784295e-07 6.8628401531283965 0.43976173866216517 YHVLVNLGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YHVLVNLGK 9 0 O75643;A0A494C1A5;O75643-2 O75643 SNRNP200 U5 small nuclear ribonucleoprotein 200 kDa helicase 0 209171000.0 50057000.0 92990000.0 66124000.0 False True 64799773.270986155 87815024.75522055 54090110.48953525 1.0 1.3551748767389498 0.8347268479371962 25.949485429460385 -6.722977089626728 1.7485080925506393 1.2153950240740874 0.8353948078845134 0.5265419564425613 0.1494072420940721 0.34958021000095146 2.0902461553284324 0.06780432533257232 0.1696272113089375 1.8924434482399302e-07 6.722977089626728 -0.380000216189574 YHYELLNYIDLPVLAIHGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YHYELLNYIDLPVLAIHGK 19 0 Q9NVP1;H7C452 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 43797100.0 12337900.0 18890200.0 12569000.0 False True 18717496.321310963 15519096.22019373 10084731.640811587 1.0 0.8291224399774201 0.5387863562355576 24.15788413511608 -6.96310371586469 0.38922840924518143 1.0179853937245535 0.3395042245325091 0.9998685607199695 0.0021826792326994685 0.07861047550059973 0.017166548183370864 0.0037502439109468834 0.024430588085236547 1.0886700719741592e-07 6.96310371586469 -0.6784811691920445 YHYELLNYIDLPVLAIHGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YHYELLNYIDLPVLAIHGK 19 0 Q9NVP1;H7C452 Q9NVP1 DDX18 ATP-dependent RNA helicase DDX18 0 15859100.0 8822100.0 1950600.0 5086400.0 False True 7335967.035296386 1940091.7306362141 6149942.723143585 1.0 0.2644629837213862 0.8383274752399588 22.80655572541618 -10.234027278541564 7.573441292071423 1.0000007092746688 0.5513952294816579 0.4489732622235756 0.23427919762037125 2.8058062429367777e-06 2.8386033935924887e-07 0.22684021933089193 0.0756132858955445 5.834084585589948e-11 10.234027278541564 -0.4486054797930109 YIAIVSTTVETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIAIVSTTVETK 12 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 14312700.0 4740000.0 5664800.0 3907900.0 False True 6214185.902225297 4819633.921217454 3503547.9952237806 1.0 0.775585731912453 0.5637983881314464 22.56713397077858 -6.971825847432607 0.21004761736468344 1.1108156451187858 0.22265586208214674 0.9999933372948936 0.00045968817355221186 0.07571459421935209 0.006868289140986427 0.00633965956515105 0.021943895443603794 1.0670239132208835e-07 6.971825847432607 -0.8881597830366391 YIAIVSTTVETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIAIVSTTVETK 12 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 15352800.0 4913300.0 3755300.0 6684200.0 False True 4757329.980904445 5254810.873630788 4933407.49829828 1.0 1.1045714496835815 1.0370118360720397 22.181720667213064 -10.705274225119235 6.057588726809999 0.9988394751086419 1.0707916428778106 0.594148797745824 0.027581096761311038 0.00043926003494327 2.137174228388762e-05 0.027136341157531444 0.008901760702224426 1.9711776889108274e-11 10.705274225119235 0.07195216776916868 YIAIVSTTVETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIAIVSTTVETK 12 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 30875000.0 0.0 20739000.0 10136000.0 False True 0.0 17037963.41545341 8132615.157233389 0.0 YIAIVSTTVETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIAIVSTTVETK 12 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 13620500.0 4740000.0 4190300.0 4690200.0 False True 6492506.093683576 4005158.6905309176 3582471.3577011065 1.0 0.616889477304835 0.5517855980430143 22.630344032301473 -13.999999999999794 0.24935567762764102 3.655727896840942 0.5254474461380887 0.9995414817866618 0.00423420046830199 13.972525774718589 0.15801407922096353 18.579567289007485 0.03015304081263239 1.0000000000004744e-14 13.999999999999794 -3.1302804507028537 YIAIVSTTVETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIAIVSTTVETK 12 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 11674700.0 4913300.0 2987200.0 3774200.0 False True 4085626.6460957997 2971107.3606872223 4563367.770070877 1.0 0.727209708093713 1.1169321539528345 21.96212594264734 -6.718535858555309 1.764475114091036 0.833778378260912 1.1162791183571057 0.505619432065596 0.11481246838478376 0.35818472232488796 2.178570493647295 0.051680343060269744 0.12996626197649047 1.9118954578982418e-07 6.718535858555309 0.28250074009619375 YIAIVSTTVETK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIAIVSTTVETK 12 0 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 0 21500300.0 0.0 15160000.0 6340300.0 False True 0.0 14316332.673288995 5186430.45697175 0.0 YIAIVSTTVETK(ub)EPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIAIVSTTVETKEPEK 16 1 P50395;P50395-2 P50395 GDI2 Rab GDP dissociation inhibitor beta 1 13259700.0 5332300.0 4775600.0 3151800.0 True False 5163029.055253448 6682521.984425009 2326249.0280267647 1.0 1.294302610523847 0.45055896512141 22.29978628629854 -6.812472770347858 1.404007782597975 1.1599328747923434 0.4349338756918783 0.8662028525034067 0.12790220121840287 0.20345320966956137 0.7899452305722108 0.07161916293354478 0.1655003307196753 1.5400230803099641e-07 6.812472770347858 -0.7249989991004651 down YIASLK(ub)QR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIASLKQR 8 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 5941200.0 2592200.0 1942400.0 1406600.0 True False 3398399.3029005066 1652601.4914158983 1261058.525059947 1.0 0.48628820339193696 0.3710742654589305 21.696423944644884 -13.999999999999932 0.2100512761042964 3.9716041861207145 0.3032470441793353 0.9994900403402014 0.0061739650446678155 12.747885117087632 0.1452657675721124 15.634286546170982 0.0682225313472579 1.0000000000001554e-14 13.999999999999932 -3.6683571419413794 YIASLK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIASLKQR 8 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 9585200.0 2601800.0 2760100.0 4223300.0 True False 2519207.283153314 3862222.3237313526 3117091.03371579 1.0 1.5331101769827271 1.2373301135482984 21.264538402819145 -10.15245121901554 4.532472780790704 0.9999599946220463 1.3852201450952508 0.6934035396960254 0.12075170560885244 84490129.12769869 5.298290582096154 48927.95005383634 0.04133652058002285 7.039612940952052e-11 10.15245121901554 0.3852601504732045 YIASLK(ub)QR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIASLKQR 8 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 15823500.0 1924700.0 3762800.0 10136000.0 True False 2919910.6144179483 3091298.9411094096 8132615.157233389 1.0 1.0586964292143668 2.785227437126371 21.477492774693246 -6.914119998024829 0.8671966283863544 0.9532538710677514 3.029201387790309 0.9923859035005522 0.07225692649425718 0.10175646157070704 0.12445166011613744 0.06039024585844745 0.17187265762175277 1.2186528317228346e-07 6.914119998024829 2.0759475167225574 up YIASLK(ub)QR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIASLKQR 8 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 7288600.0 2592200.0 2030400.0 2666000.0 True False 3550606.391571003 1940690.2143650749 2036345.7079935102 1.0 0.546579936027884 0.5735205436535329 21.759634006167776 -10.691104977525589 6.70061387807547 1.003746422988756 0.5600502398407112 0.9971955331531331 0.010998457007228863 0.0006187249965410353 2.8522866969300982e-05 0.010704097011832784 0.003549736735247965 2.0365497440410712e-11 10.691104977525589 -0.4436961831480448 YIASLK(ub)QR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIASLKQR 8 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 11031000.0 2601800.0 5264900.0 3164300.0 True False 2163511.9792831796 5236536.938699171 3825940.499929854 1.0 2.420387309542032 1.7683934901055989 21.04494367825342 -10.180573421133737 5.277545596979879 0.9999481680979768 2.0943903998242055 0.7897663243488342 0.26617536217931526 0.0001623431109649183 2.520637039977839e-05 0.2577352906616177 0.08590772874073453 6.598216764317191e-11 10.180573421133737 1.0944422317262288 YIASLK(ub)QR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIASLKQR 8 1 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 14414700.0 1924700.0 2496100.0 9993900.0 True False 2491562.091509022 2357189.840751754 8175112.746073535 1.0 0.9460690740097571 3.281119412569909 21.248619096785696 -6.901614208851214 0.9510027972862116 0.9071666267059295 3.5344209306069083 0.9873521717338616 0.12238900307382257 0.11022785286696676 0.17079412520434983 0.09621984862459602 0.25243837170248146 1.2542548560632814e-07 6.901614208851214 2.627254303900979 up YICPHAPVRPVTLNMNVAMPSWFDIIGLSPDSQEDESGIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YICPHAPVRPVTLNMNVAMPSWFDIIGLSPDSQEDESGIK 40 1 O75608;B4DP64 O75608 LYPLA1 Acyl-protein thioesterase 1 0 1195610000.0 520080000.0 324320000.0 351210000.0 False True 788999382.94097 266442562.07627434 281793189.5591883 1.0 0.3376967939862237 0.35715261082817734 29.555448931038075 -10.347357056793943 8.976402218338556 1.0000009041595368 0.34742470245672774 0.9993337921524449 0.007942803965305605 1.4371726204136238e-07 1.0455923533406688e-08 0.007690597524937447 0.002563528956651573 4.4941021871309163e-11 10.347357056793943 -0.6525762017028091 YICPHAPVRPVTLNMNVAMPSWFDIIGLSPDSQEDESGIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YICPHAPVRPVTLNMNVAMPSWFDIIGLSPDSQEDESGIK 40 1 O75608;B4DP64 O75608 LYPLA1 Acyl-protein thioesterase 1 0 38651000.0 19945000.0 7955000.0 10751000.0 False True 25819195.67472716 7512297.256992989 8794428.314575547 1.0 0.2909578343041228 0.3406158900288237 24.621940722402858 -10.103313450513397 7.803537220920781 1.000000068843754 0.31578686216647334 0.9960649923560425 0.020272816357368384 2.427499569330541e-08 2.792445376404684e-09 0.019629071934395507 0.00654302334440076 7.882909660221011e-11 10.103313450513397 -0.6842132066772807 YIDENQDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIDENQDR 8 0 Q96KP4;Q96KP4-2;J3QKT2;J3QRA8;A0A087WYZ1;J3KSV5;J3QRD0;J3QKQ0;J3QLU1;J3QR27;J3QL02;J3QQN6;J3KSS4;J3QRP4 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 5303970.0 2043700.0 787970.0 2472300.0 False True 1978823.8621648203 1102610.5302092668 1824730.46258981 1.0 0.5572049899393361 0.9221287945222001 20.916211771153524 -9.992204364335153 6.9609957726618985 1.0000000251343832 0.7396668922307679 0.4042539793883946 0.14897951937052448 5.808110311916697e-08 8.337287749802862e-09 0.14424881225883074 0.048082933120668706 1.0181121860592824e-10 9.992204364335153 -0.26033313290361537 YIDNQVVSTK(ub)GER ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIDNQVVSTKGER 13 1 Q9H467 Q9H467 CUEDC2 CUE domain-containing protein 2 1 10113100.0 3637600.0 3663500.0 2812000.0 True False 4768928.8265685085 3116920.08021115 2521041.2146086833 1.0 0.6535891378471118 0.5286388843892021 22.185233820850137 -13.999999999999998 0.14191372610038433 2.6577569303685276 0.3775143817430166 0.9995954150200568 0.00401051286659789 11.936476243231786 0.11816461370181913 5.4740624649934 0.1352850289708722 1.0000000000000041e-14 13.999999999999998 -2.280242548625511 YIDNQVVSTK(ub)GER ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIDNQVVSTKGER 13 1 Q9H467 Q9H467 CUEDC2 CUE domain-containing protein 2 1 25898000.0 7000300.0 7058700.0 11839000.0 True False 6778079.308270497 9877275.720634207 8738010.73761306 1.0 1.4572381454112115 1.289157346824061 22.692445086786265 -10.018884516613895 4.844193358219993 0.9999937217543184 1.3731977461228548 0.8679563995782371 0.06861869870854224 4.887629946442568e-06 9.898208041175425e-07 0.06644094314608608 0.022146589774413764 9.57448632923619e-11 10.018884516613895 0.3732040243685364 YIDNQVVSTK(ub)GER ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIDNQVVSTKGER 13 1 Q9H467 Q9H467 CUEDC2 CUE domain-containing protein 2 1 32574600.0 6016600.0 11157000.0 15401000.0 True False 9127622.072378568 9165946.179961115 12356985.599501908 1.0 1.0041986957039468 1.3538011873756073 23.121807627647442 -6.9095241448966815 0.8989863656133728 0.9890111675668521 1.398521747363762 0.9907398499549555 0.01595513842645548 0.10473455100195354 0.14048877479708158 0.01303186746180491 0.03585556168701596 1.231617511220914e-07 6.9095241448966815 0.40951057979690975 YIDNQVVSTK(ub)GER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIDNQVVSTKGER 13 1 Q9H467 Q9H467 CUEDC2 CUE domain-containing protein 2 1 11632200.0 3637600.0 3686600.0 4308000.0 True False 4982519.022443748 3523713.8220440727 3290539.1260450236 1.0 0.7072153274621753 0.6604167713605901 22.248443882373028 -13.999999999999556 0.2580671335741203 3.1218988102464094 0.6429928761845857 0.9995584139431745 0.0031577614959216963 14.332482271901887 0.1607514098465962 15.841567704657967 0.02067005557645481 1.0000000000010225e-14 13.999999999999556 -2.4789059340618236 YIDNQVVSTK(ub)GER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIDNQVVSTKGER 13 1 Q9H467 Q9H467 CUEDC2 CUE domain-containing protein 2 1 27427100.0 7000300.0 14233000.0 6193800.0 True False 5821059.615872116 14156324.003970694 7488894.943104503 1.0 2.4319153106370965 1.2865174791690415 22.47285036222054 -6.5905189096522285 2.226986112067729 1.9688528485747903 1.2898789726929953 0.0 0.6204203465678314 0.6680995571720965 6.247467032888048 0.2325080314060022 0.6914061351891222 2.5673264214988253e-07 6.5905189096522285 -0.6789738758817949 YIDNQVVSTK(ub)GER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIDNQVVSTKGER 13 1 Q9H467 Q9H467 CUEDC2 CUE domain-containing protein 2 1 39473600.0 6016600.0 22911000.0 10546000.0 True False 7788607.304916704 21635982.709612396 8626736.21109791 1.0 2.7779013452063857 1.1076095986572747 22.89293394973989 -6.631438846037168 2.0750358962161783 2.170071576427301 1.1143441873773352 0.12274269440938368 0.7623463798683323 0.55528696658382 4.558161696069701 0.30027530812713005 0.844542675120452 2.336475083260301e-07 6.631438846037168 -1.0557273890499659 YIDPSGFVK(ub)ALGLDTGQQQDAQEFSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIDPSGFVKALGLDTGQQQDAQEFSK 26 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;Q86UV5-7;Q86UV5-4 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 39077700.0 15732000.0 7445700.0 15900000.0 True False 15232596.27126143 10418806.838812547 11735313.010224493 1.0 0.6839810268239817 0.7704079331745249 23.860658522546903 -10.009199446976721 6.800988722003254 1.0000000498229875 0.727194479999253 0.929994331887077 0.035283636767692084 2.6650857687445067e-08 3.892337914007994e-09 0.03416324050756672 0.0113877447995749 9.790402641406409e-11 10.009199446976721 -0.2728055698237345 YIDPSGFVK(ub)ALGLDTGQQQDAQEFSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIDPSGFVKALGLDTGQQQDAQEFSK 26 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;Q86UV5-7;Q86UV5-4 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 92810000.0 18009000.0 32301000.0 42500000.0 True False 27320969.63425613 26536634.181135103 34099856.37158824 1.0 0.9712918149091754 1.2481202837264045 24.703505350683937 -6.881302363042695 1.0724654318615523 0.9818794355323941 1.2682390565790822 0.9747226906712378 0.019759941704696984 0.12648466768301955 0.26534433097401156 0.01417555027747352 0.0343976650966151 1.3143094694679392e-07 6.881302363042695 0.2863596210466881 YIDPSGFVK(ub)ALGLDTGQQQDAQEFSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIDPSGFVKALGLDTGQQQDAQEFSK 26 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;Q86UV5-7;Q86UV5-4 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 37075200.0 15732000.0 12808000.0 8535200.0 True False 13081855.045769475 12739000.761811065 10319870.857694065 1.0 0.9737916157334823 0.7888690725885543 23.64106379798118 -6.9325095045117004 0.7258948640383331 1.002566925141746 0.7483593375075421 0.997008914454014 0.005138848201259089 0.09135557487635969 0.07144841788940957 0.004753677220365473 0.01650748148601952 1.1681281651586503e-07 6.9325095045117004 -0.2542075876342038 YIDPSGFVK(ub)ALGLDTGQQQDAQEFSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIDPSGFVKALGLDTGQQQDAQEFSK 26 1 Q86UV5;Q86UV5-2;Q86UV5-8;Q86UV5-3;Q86UV5-7;Q86UV5-4 Q86UV5 USP48 Ubiquitin carboxyl-terminal hydrolase 48 1 88783000.0 18009000.0 21052000.0 49722000.0 True False 23313005.51046185 19880437.693804696 40673106.190803155 1.0 0.852761677806117 1.7446530509569373 24.474631672776386 -6.864516609110822 1.1627974836787132 0.918945542841045 1.7917012983782212 0.9588924865298011 0.07915205432550824 0.142215929852718 0.3628723074420885 0.052988160925380695 0.12438116848460061 1.3661028296036767e-07 6.864516609110822 0.8727557555371762 YIDQEELNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIDQEELNK 9 0 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 0 154993800.0 3894800.0 82750000.0 68349000.0 False True 5106120.517296847 70404022.55697362 61276901.12990351 1.0 13.788163111011945 12.00067662373609 22.28379615870544 -9.8918018697015 8.262199899015688 0.99999999169797 12.894419867374019 0.9833441874858444 0.7297383026576247 1.106957188831534e-07 2.0389058779524266e-08 0.7065660733206433 0.23552202444022036 1.2829157305569596e-10 9.8918018697015 11.894419875676048 YIDQEELNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIDQEELNK 9 0 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 0 157691000.0 39938000.0 15623000.0 102130000.0 False True 38670190.05095595 21861345.372868713 75379089.16567464 1.0 0.5653281078800462 1.9492815801098247 25.204718519009756 -6.822288473486661 1.3619302036953012 0.7662347319957068 1.981004282501637 0.8895552014718159 0.19204486185619157 0.19053482698885782 0.6938046912201041 0.1107893919361939 0.2552109118571056 1.5056066577084405e-07 6.822288473486661 1.2147695505059302 YIDQEELNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIDQEELNK 9 0 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 0 695280100.0 6213100.0 677160000.0 11907000.0 False True 9425726.938452812 556315507.3247713 9553576.230976496 1.0 59.020965805326824 1.0135638655096315 23.16817245667721 -12.233774946893769 2.5532244301712784e-18 9.699700781871904 44.53137592188519 0.0 28.17381003983868 0.0 0.29893393084285613 30.077131415908553 30.077131415908543 5.837475261696225e-13 12.233774946893769 34.83167514001329 YIDQEELNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIDQEELNK 9 0 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 0 152272800.0 3894800.0 74752000.0 73626000.0 False True 5334812.813012397 71449209.46819259 56237055.17506753 1.0 13.39301152121353 10.541523600958788 22.34700622022833 -10.064903291486457 7.948996685897735 0.9999995954076345 11.96726756108616 0.9517465077511754 1.1641150687223547 8.343764950864758e-06 9.973126915799308e-07 1.1271495684950488 0.3757165228525653 8.611854992614266e-11 10.064903291486457 10.967267965678525 YIDQEELNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIDQEELNK 9 0 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 0 44150100.0 39938000.0 2286700.0 1925400.0 False True 33210216.553390626 2274381.093225589 2327992.237956248 1.0 0.06848438008734947 0.0700986768398103 24.985123794444032 YIDQEELNK(ub)TK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIDQEELNKTK 11 1 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 6454900.0 2645800.0 2126100.0 1683000.0 True False 3468669.421963648 1808894.1674728894 1508859.3044759645 1.0 0.521495117412733 0.43499657099689376 21.72595092190601 -13.999999999999998 0.24058230535258426 4.176204529709864 0.39696226403458906 0.999525929945405 0.005410174604066003 13.644059980379113 0.15523895542133284 20.827001447583864 0.042122387343261895 1.0000000000000041e-14 13.999999999999998 -3.7792422656752747 YIDQEELNK(ub)TK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIDQEELNKTK 11 1 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 6665400.0 2219400.0 2592600.0 1853400.0 True False 2148946.36183814 3627838.7002303964 1367938.93919183 1.0 1.688194160940927 0.6365626259846424 21.03519804256178 -6.730162037773596 1.722876575029394 1.4140804784990622 0.6371956765858247 0.5599338357019363 0.28929589739960293 0.33592323469401886 1.953576190653184 0.13306858515593806 0.330110213717879 1.861392510815374e-07 6.730162037773596 -0.7768848019132375 YIDQEELNK(ub)TK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIDQEELNKTK 11 1 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 9574600.0 2902200.0 3074100.0 3598300.0 True False 4402849.579240273 2525502.8369470737 2887094.4278090843 1.0 0.5736064318106588 0.6557331509624871 22.07000612561554 -10.063246365460532 5.14854419937537 1.0000057931583415 0.6146697913855075 0.9670531093676947 0.03352809269888984 2.229565809917053e-06 4.056255104556462e-07 0.032463924104915304 0.010821145387202599 8.644773811403932e-11 10.063246365460532 -0.385336001772834 YIDQEELNK(ub)TK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIDQEELNKTK 11 1 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 6274300.0 2645800.0 1944400.0 1684100.0 True False 3624023.7600565418 1858489.9787290462 1286350.2651282323 1.0 0.512824998338325 0.35495083650007936 21.7891609834289 -13.999999999999998 0.1575929484355989 3.387468582507699 0.19555582629742455 0.9995429077580267 0.0058695940444802325 11.994516863219088 0.12536590183789384 8.755357052963438 0.1448482161773541 1.0000000000000041e-14 13.999999999999998 -3.1919127562102747 YIDQEELNK(ub)TK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIDQEELNKTK 11 1 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 7366800.0 2219400.0 4090800.0 1056600.0 True False 1845529.4360908198 4068762.0484397793 1277530.1748335776 1.0 2.204658440484258 0.6922296387423806 20.815603317996057 -6.694536481506712 1.850450177939179 1.7520192149097154 0.6971751880634419 0.3916620503055519 0.509027577110673 0.40699339586470124 2.705392233166289 0.21978734691481103 0.56905801049792 2.0205216974573238e-07 6.694536481506712 -1.0548440268462733 YIDQEELNK(ub)TKPIWTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIDQEELNKTKPIWTR 16 2 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 47409000.0 15207000.0 18742000.0 13460000.0 True False 19936524.264797505 15945766.655743824 12067288.317436995 1.0 0.7998268125352083 0.6052854628599708 24.248910576303594 -6.971474589988379 0.2201361237563438 1.0895597919574866 0.3100583072912631 0.9999917111485019 0.0004639121864524543 0.07582706884136534 0.007293705536260997 0.005383034028676073 0.0197120660649181 1.067887271422219e-07 6.971474589988379 -0.7795014846662236 YIDQEELNK(ub)TKPIWTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIDQEELNKTKPIWTR 16 2 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 62131000.0 25571000.0 17574000.0 18986000.0 True False 24759262.60185774 24591389.847199325 14012997.03220894 1.0 0.9932197999044681 0.5659698859996547 24.561465012023614 -6.910349564463282 0.8933531576067802 1.0130826975426428 0.510340583622425 0.9910527633951978 0.01920405464551717 0.10418725829831023 0.1375175916342089 0.01574984146433458 0.043582583152460996 1.2292789235323686e-07 6.910349564463282 -0.5027421139202178 YIDQEELNK(ub)TKPIWTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIDQEELNKTKPIWTR 16 2 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 208110000.0 41954000.0 75466000.0 90690000.0 True False 63647285.24824147 61998502.681450844 72765081.749161 1.0 0.9740950056179155 1.1432550731010394 25.923595644285935 -6.867831173082827 1.1454362112549188 0.9855232578747477 1.152764937484648 0.9624740280696052 0.014411034812207691 0.13895515292486668 0.3420856835018315 0.009775959936133049 0.023062953780951374 1.3557163288470318e-07 6.867831173082827 0.16724167960990033 YIDQEELNK(ub)TKPIWTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIDQEELNKTKPIWTR 16 2 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 62131000.0 25571000.0 26179000.0 10381000.0 True False 21263419.487374224 26037968.53087532 12551619.10367914 1.0 1.2245428608665754 0.5902916561060195 24.34187028745789 -6.811018700708241 1.410353025305349 1.1222250503602593 0.5789453629821057 0.8624522101975369 0.09738581370004647 0.20541001354614877 0.805098802887935 0.054293430497368136 0.12552864911488928 1.5451879023580335e-07 6.811018700708241 -0.5432796873781536 YIDQEELNK(ub)TKPIWTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIDQEELNKTKPIWTR 16 2 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 229505000.0 41954000.0 79421000.0 108130000.0 True False 54310280.03697682 75001151.5333301 88451449.50749251 1.0 1.3809752312502537 1.6286318068562873 25.694721966378385 -8.746135660970326 0.08665275036358748 2.352765325921062e-20 2.568394175279555 0.9999838056674583 0.0010404637110141023 0.2911848524225697 0.0245546625980876 0.3844899539759213 0.31930433202174857 1.794173091776032e-09 8.746135660970326 2.568394175279555 YIDQEELNKTK(ub)PIWTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIDQEELNKTKPIWTR 16 2 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 6499100.0 2527300.0 1896100.0 2075700.0 True False 2447072.2448740797 2653222.618030872 1532011.9003347773 1.0 1.0842436808265954 0.6260591216887472 21.222625264032445 -6.859249971146815 1.1895029534853776 1.0456208634604842 0.604186242865359 0.9527188373466751 0.04329850364592845 0.14758302777525006 0.39721796691414607 0.028398615415894977 0.06623661880492943 1.382770255200189e-07 6.859249971146815 -0.44143462059512517 YIDQEELNKTK(ub)PIWTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIDQEELNKTKPIWTR 16 2 P08238;P07900;P07900-2;Q14568;Q58FF8 P08238;P07900;Q58FF8 HSP90AB1;HSP90AA1;HSP90AA2P;HSP90AB2P Heat shock protein HSP 90-beta;Heat shock protein HSP 90-alpha;Heat shock protein HSP 90-alpha A2;Putative heat shock protein HSP 90-beta 2 1 37506300.0 5759300.0 16219000.0 15528000.0 True False 8737279.161228899 13324592.730374614 12458883.99383581 1.0 1.5250276984969895 1.4259455104881262 23.05875265548878 -10.053378553789509 4.894768459595179 0.9999889427945853 1.4754866044975565 0.9684602900807763 0.04045013388730619 4.881083462699889e-06 9.438859677679171e-07 0.03916658354612541 0.013055224572320816 8.843444329104908e-11 10.053378553789509 0.47549766170297125 YIDSADLEPITSQEEPVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIDSADLEPITSQEEPVR 18 0 A0A3B3IRI2;P17812;B4E1E0;P17812-2;A0A3B3IRQ8;A0A3B3ITF6 A0A3B3IRI2 CTPS1 CTP synthase 1;CTP synthase 0 8357900.0 2734100.0 1381300.0 4242500.0 False True 2647307.492070676 1932860.2933843406 3131261.97772814 1.0 0.7301230775698415 1.1828100766937821 21.336094346900513 -6.745228340023874 1.6674512645030148 0.8403999653841331 1.183393518765024 0.628150462401027 0.1133880343772409 0.3084723186116652 1.685889542336809 0.053752444869035666 0.1311595861607948 1.7979253671604498e-07 6.745228340023874 0.3429935533808909 YIEIFK(ub)SSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIEIFKSSR 9 1 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;E7EN40 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 13299400.0 4986900.0 5323700.0 2988800.0 True False 6537874.193208301 4529424.711620066 2679547.646594032 1.0 0.69279777765154 0.40984998600578915 22.640390185251505 -7.146712853517354 0.21850297268686297 1.1437946210711138 1.0783433948871752e-13 0.9999870086008502 0.0008686151379001378 0.08254436548194889 0.009146476178613229 0.01092399603328078 0.03352322787780115 7.133245095791737e-08 7.146712853517354 -1.143794621071006 down YIEIFK(ub)SSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIEIFKSSR 9 1 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;E7EN40 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 18074100.0 6579400.0 6215200.0 5279500.0 True False 6370540.548381483 8696961.77183982 3896640.568394978 1.0 1.3651842737347295 0.6116656096608583 22.602984361489096 -6.774924491612481 1.5556305274486615 1.2081393958364322 0.6066179082742876 0.7490294599822547 0.15413386576168298 0.2585396347920811 1.2353782910372697 0.07806866624814557 0.18500723569414 1.6790959278984163e-07 6.774924491612481 -0.6015214875621445 YIEIFK(ub)SSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIEIFKSSR 9 1 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;E7EN40 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 22882900.0 4986900.0 6475000.0 11421000.0 True False 6830691.695905199 6188913.090038358 8723595.022878425 1.0 0.9060448583484497 1.27711737130633 22.703600246774396 -6.839593735841509 1.284312804354741 0.9500157277849368 1.2892220550354103 0.9237495607653161 0.043497093812035884 0.16927277938687402 0.5425465375079223 0.026559001734248387 0.06117918384055484 1.4467925512828035e-07 6.839593735841509 0.3392063272504735 YIEIFK(ub)SSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIEIFKSSR 9 1 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;E7EN40 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 21694300.0 6579400.0 7322000.0 7792900.0 True False 5471062.616840563 7282554.932696784 9422359.359701492 1.0 1.3311042922960228 1.7222174227541065 22.383389636923372 -6.968923160431931 0.28272744035568126 0.9166168578715967 2.1486675091975482 0.9999727211273212 0.0015417062995821355 0.07665370162463936 0.010275240689602352 0.007112693631383084 0.03577733569343446 1.0741794497167436e-07 6.968923160431931 1.2320506513259515 YIEIFK(ub)SSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIEIFKSSR 9 1 P55795;P31943;G8JLB6;E9PCY7;D6RBM0;H0YB39;E5RGV0;E7EN40 P55795;P31943 HNRNPH2;HNRNPH1 Heterogeneous nuclear ribonucleoprotein H2;Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 1 53954100.0 6977100.0 10596000.0 36381000.0 True False 9031993.489202261 10006323.28536741 29760031.30058345 1.0 1.1078753873472074 3.294957125042388 23.106613015455128 -6.917158293410183 0.845530162087584 0.9466262843068818 3.6255836571379705 0.9933545448630481 0.08619434495574183 0.0998729042522311 0.1144898802503565 0.0731686474556033 0.21356045688934452 1.2101569702473287e-07 6.917158293410183 2.6789573728310887 up YIEIYVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIEIYVQK 8 0 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 9764600.0 3195500.0 3310800.0 3258300.0 False True 4189331.445266023 2816841.5453973226 2921162.371820578 1.0 0.6723845038760005 0.6972860490953787 21.998288599034787 -10.730040447506967 6.823384937292699 1.004534189373499 0.6848352764856991 0.99533974007027 0.010166013265719757 0.0007077152968098271 2.799992343381256e-05 0.009934427360099326 0.003281066672954694 1.86191372143792e-11 10.730040447506967 -0.31969891288779984 YIEIYVQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIEIYVQK 8 0 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 6979800.0 2088800.0 2102300.0 2788700.0 False True 2022492.1873513127 2941759.3533496675 2058255.8107932734 1.0 1.454521986165119 1.0176829476354108 20.94770269902947 -10.479251227281328 3.0758046478724634 0.9941007015340988 1.2361024668266893 0.28031173537846943 0.17833879308176798 39330109.72462348 46417530.3026421 1972236.2370335993 0.06460266726218811 3.3170252135815376e-11 10.479251227281328 0.24200176529259054 YIEIYVQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIEIYVQK 8 0 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 29328000.0 10227000.0 0.0 19101000.0 False True 15515106.693849612 0.0 15325678.977734298 1.0 0.0 0.9877907564638014 23.887170282196987 -11.975709473667681 17.665531472671635 0.8674809897117017 0.5445058404087273 0.0 0.48320563478465645 0.0 0.0 0.0 0.13815903377105848 1.0575247160683003e-12 11.975709473667681 -0.32297514930297444 YIEIYVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIEIYVQK 8 0 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 10431700.0 3195500.0 2407800.0 4828400.0 False True 4376962.705140482 2301415.4344701716 3688031.36401945 1.0 0.5258019292161883 0.8426005914302347 22.061498660557678 -10.206452982741412 5.479137829184078 1.0000141728408691 0.6842012603231827 0.5698794718299489 0.12933251227022818 2.2392286857825266e-05 3.243160084484285e-06 0.12523128305074988 0.04174188884546481 6.216515448759331e-11 10.206452982741412 -0.3158129125176864 YIEIYVQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIEIYVQK 8 0 A0A087WVQ6;Q00610-2;Q00610;A0A087WX41;P53675-2;P53675 A0A087WVQ6;A0A087WX41 CLTC;CLTCL1 Clathrin heavy chain;Clathrin heavy chain 1;Clathrin heavy chain 2 0 30208000.0 10227000.0 19981000.0 0.0 False True 13239053.104308598 18869039.78528937 0.0 1.0 1.4252559935082152 0.0 23.658296604289436 -6.8522823212326704 1.4009851244444458 1.2258527544074445 5.610485441482626e-23 0.8983497063699688 0.1904733283134679 0.17245401181099831 0.6802589261651307 0.10939094828855923 0.23043265078947278 1.4051337937234288e-07 6.8522823212326704 -1.2258527544074445 down YIEK(ub)VSSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIEKVSSR 8 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 2093340.0 425810.0 711950.0 955580.0 True False 558241.0335499053 605729.8351593643 856705.7481706126 1.0 1.085068633001543 1.5346520529362437 19.090528648147842 -6.938576957176905 0.6726744820863914 0.9948078811816417 1.6509770953168919 0.9979714800073162 0.010564893144714416 0.0884218876456722 0.057611801723124384 0.010176456019485514 0.03894360983792384 1.1519219206587713e-07 6.938576957176905 0.6561692141352502 YIEK(ub)VSSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIEKVSSR 8 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 1461760.0 425810.0 557450.0 478500.0 True False 583243.464082574 532820.0157593635 365488.1550168393 1.0 0.9135464837098086 0.6266476652108603 19.153738709670733 -6.949162657296049 0.5679603969927266 1.0036073969364823 0.5226866751230816 0.9991339345600012 0.0046961222006124525 0.08382369860989639 0.03736716370358905 0.004986906512199216 0.023892496164535364 1.1241838519854362e-07 6.949162657296049 -0.4809207218134006 YIEK(ub)VSSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIEKVSSR 8 1 P49736;H0Y8E6 P49736 MCM2 DNA replication licensing factor MCM2 1 2100560.0 480640.0 1192700.0 427220.0 True False 399673.4559622831 1186274.6883675866 516549.72675790376 1.0 2.96810976728846 1.2924294046854345 18.608462234777814 -6.60693131061902 2.1650891369216634 2.317614572231728 1.2982698641468138 0.04091335199107493 0.8491839300449617 0.6212060659992522 5.51352607803136 0.3244008472409492 0.9432356253661843 2.4721151115971545e-07 6.60693131061902 -1.0193447080849143 YIELFLNSCPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIELFLNSCPK 11 0 H0Y8R1;F5H5I6;H0YAK1;Q12849-5;Q12849 H0Y8R1 GRSF1 G-rich sequence factor 1 0 5858000.0 1673200.0 2136400.0 2048400.0 False True 2193581.403291849 1817657.447621976 1836451.217640262 1.0 0.8286254820059407 0.8371931011469868 21.064856814749632 -10.296311124426309 7.16392518877383 1.0000015197696674 0.8329092915773162 0.998032011201758 0.003497715867677537 8.490379414163897e-08 8.333585390997589e-09 0.0033866796585355348 0.001128882942106706 5.054624238052325e-11 10.296311124426309 -0.16709222819235126 YIELFLNSCPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIELFLNSCPK 11 0 H0Y8R1;F5H5I6;H0YAK1;Q12849-5;Q12849 H0Y8R1 GRSF1 G-rich sequence factor 1 0 10322000.0 6207800.0 2430000.0 1684200.0 False True 6010736.786977929 3400311.672282591 1243057.495083024 1.0 0.5657063007066386 0.20680617686937627 22.519110414465068 -7.874597479311449 0.3198170058047109 1.0988769869124722 1.4391680851440607e-11 0.9991137251572342 0.009654744757022547 0.11093947645849991 0.05595396741885805 0.04529027066811459 0.08453492592279885 1.3347579636270071e-08 7.874597479311449 -1.0988769868980806 down YIELFLNSCPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIELFLNSCPK 11 0 H0Y8R1;F5H5I6;H0YAK1;Q12849-5;Q12849 H0Y8R1 GRSF1 G-rich sequence factor 1 0 30401200.0 9092100.0 12935000.0 8374100.0 False True 13793380.421545919 10626648.188383723 6718955.464501578 1.0 0.7704165232609977 0.4871144896436155 23.717472733807792 -6.968298119635788 0.29602853168414156 1.0515116855112367 0.1971921104042162 0.9999658965448232 0.001224987793431381 0.07685888959731614 0.010996341439718284 0.004795175464644197 0.025517133859230556 1.0757265321349794e-07 6.968298119635788 -0.8543195751070205 down YIELFLNSCPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIELFLNSCPK 11 0 H0Y8R1;F5H5I6;H0YAK1;Q12849-5;Q12849 H0Y8R1 GRSF1 G-rich sequence factor 1 0 8072300.0 1673200.0 2764400.0 3634700.0 False True 2291827.256529822 2642259.6673516617 2776258.71899625 1.0 1.1529052461625962 1.211373462413538 21.128066876272523 -13.999999999999746 0.13319925394969243 0.2727583645698115 1.290022063795994 0.9996313773396085 0.001711005158971783 11.933010146807293 0.11379868058000063 2.2659009219771575 0.07003810648446987 1.0000000000005849e-14 13.999999999999746 1.0172636992261825 YIELFLNSCPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIELFLNSCPK 11 0 H0Y8R1;F5H5I6;H0YAK1;Q12849-5;Q12849 H0Y8R1 GRSF1 G-rich sequence factor 1 0 10289900.0 6207800.0 1831800.0 2250300.0 False True 5162060.752169325 1821931.7298161702 2720827.325788378 1.0 0.35294658805604223 0.5270816165123524 22.299515689899344 -10.740934316243862 10.466481006322692 1.0010881055657503 0.44001410228503074 0.9323804135908269 0.07109032767716476 0.001807293945773468 4.4733960465496503e-05 0.06891925410651015 0.022944304597507285 1.8157902665530673e-11 10.740934316243862 -0.5610740032807195 YIELFLNSCPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIELFLNSCPK 11 0 H0Y8R1;F5H5I6;H0YAK1;Q12849-5;Q12849 H0Y8R1 GRSF1 G-rich sequence factor 1 0 25460800.0 9092100.0 11017000.0 5351700.0 False True 11769902.682085093 10403894.265278677 4377745.513079147 1.0 0.8839405512769778 0.3719440705098174 23.48859905590024 -6.942633171450808 0.6346042321948361 1.0055895846927974 0.22248311379268854 0.9984887357102072 0.01060735679872577 0.08658590740989336 0.04929354860598524 0.010544387781656657 0.043581139617653836 1.141213310911757e-07 6.942633171450808 -0.7831064709001088 down YIELFLNSTPGGGSGMGGSGMGGYGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIELFLNSTPGGGSGMGGSGMGGYGR 26 0 P31942-2;P31942;P31942-3;P31942-4 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 16133300.0 9963600.0 2081900.0 4087800.0 False True 9647310.971798897 2913213.526965072 3017082.5486286576 1.0 0.3019715582384566 0.3127381876098137 23.201695440381968 -10.007605021246974 5.060818038600404 1.0000064280493417 0.3073548729186871 0.9998188153997305 0.00439545805533968 12126516.887084652 2.10638027053092 929.7219022007444 0.001504682201560994 9.82641221614988e-11 10.007605021246974 -0.6926515551306546 YIELFLNSTPGGGSGMGGSGMGGYGR ddPTM_RPMI8226_Bortezomib_8h_R1 2 YIELFLNSTPGGGSGMGGSGMGGYGR 26 0 P31942-2;P31942;P31942-3;P31942-4 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 102267900.0 25435000.0 39862000.0 36970900.0 False True 38586754.54757652 32748314.656772465 29663585.410078876 1.0 0.8486931601463036 0.7687504626361983 25.201602371085876 -13.999999999995145 0.07984909258059927 1.8166270318598152 0.5293563501344523 0.9998872988396627 0.0010180020936109342 12.260002133097124 0.07946388467711575 1.7696186056464607 0.21744974736138148 1.0000000000111785e-14 13.999999999995145 -1.287270681725363 YIELFLNSTPGGGSGMGGSGMGGYGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIELFLNSTPGGGSGMGGSGMGGYGR 26 0 P31942-2;P31942;P31942-3;P31942-4 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 15607400.0 9963600.0 2250100.0 3393700.0 False True 8285174.862320661 2237978.2646901193 4103306.979304095 1.0 0.2701184105199762 0.49525894715452834 22.982100715816244 -10.257202132339515 5.07312009996584 1.0001052445441716 0.3826886788377829 0.9092885901322768 0.0919132391960648 0.00010942830120292515 1.6022444416810806e-05 0.08900964706739381 0.029664870391733537 5.530926251079365e-11 10.257202132339515 -0.6174165657063887 YIELFLNSTPGGGSGMGGSGMGGYGR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 YIELFLNSTPGGGSGMGGSGMGGYGR 26 0 P31942-2;P31942;P31942-3;P31942-4 P31942-2 HNRNPH3 Heterogeneous nuclear ribonucleoprotein H3 0 95263000.0 32492000.0 32455000.0 30316000.0 False True 42061534.51307267 30648850.719762105 24798799.06842826 1.0 0.7286669655439338 0.5895837932570155 25.325998148470873 -13.99999999674692 0.08550224215560144 2.419051146575268 0.2134403792003602 0.999863007138067 0.0019947325490335703 12.20520766472244 0.08382790902414686 3.2003205171339517 0.33944854247031325 1.0000000074904926e-14 13.99999999674692 -2.2056107673749077 YIESPVLFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIESPVLFLR 10 0 Q14166 Q14166 TTLL12 Tubulin--tyrosine ligase-like protein 12 0 3660100.0 2045900.0 0.0 1614200.0 False True 1980954.024369041 0.0 1191392.5950380107 1.0 0.0 0.6014236475869168 20.917763966671973 -10.094531610986994 6.6517982520653645 1.000000663228435 0.3007118237934576 0.6431835741452387 0.2455301759719029 2.4151267899873665e-06 3.291249817886946e-07 0.2377337937856129 0.07924452354421255 8.043931970637433e-11 10.094531610986994 -0.6992888394349774 YIESPVLFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIESPVLFLR 10 0 Q14166 Q14166 TTLL12 Tubulin--tyrosine ligase-like protein 12 0 8848200.0 1853300.0 3317800.0 3677100.0 False True 2538515.093549321 3171208.625502586 2808644.7122516613 1.0 1.2492376482460226 1.106412453244329 21.275553407419686 -10.418141262080676 4.712949197884863 0.9996780990421 1.1778250507452608 0.6739355747795941 0.05830814169490111 0.00019757228821210154 2.439228916689102e-05 0.056558123644863616 0.018818871811013205 3.8182005680830776e-11 10.418141262080676 0.17814695170316075 YIEVFK(ub)SHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIEVFKSHR 9 1 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 16121700.0 6133900.0 5767400.0 4220400.0 True False 8041602.300772104 4906926.401149119 3783713.4929354475 1.0 0.6101926230146928 0.47051736102047215 22.939051558422992 -13.999999999999998 0.14289367006255382 2.8673515593165138 0.3035429248884753 0.9995916533241728 0.004527633091183954 11.938053086330466 0.11863770102818656 6.206570167338309 0.14958203724195251 1.0000000000000041e-14 13.999999999999998 -2.5638086344280384 YIEVFK(ub)SHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIEVFKSHR 9 1 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 25474700.0 5832500.0 10349400.0 9292800.0 True False 5647350.480049082 14481969.39140801 6858736.901975728 1.0 2.5643829690701514 1.2145052668868743 22.42914273847555 -6.610357760483468 2.1525112098992203 2.0449165014805875 1.219350814719595 0.05148865078273779 0.6743950653279603 0.6116300157421333 5.370689814153001 0.25868710739670386 0.7486159346260413 2.452687623068906e-07 6.610357760483468 -0.8255656867609924 YIEVFK(ub)SHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIEVFKSHR 9 1 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 66966300.0 11053200.0 14219700.0 41693400.0 True False 16768512.497160312 11682083.435976794 33452681.215133637 1.0 0.6966678432541415 1.9949701096503778 23.999251380057643 -6.845161269487015 1.2582656496130586 0.8385778208513653 2.04220907183204 0.9329576214955642 0.14358277492352933 0.16285958867859404 0.4986300108827686 0.08939441059381 0.20631736069216866 1.4283634562235423e-07 6.845161269487015 1.2036312509806746 YIEVFK(ub)SHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIEVFKSHR 9 1 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 17116300.0 6133900.0 4926700.0 6055700.0 True False 8401768.592414709 4709022.103581772 4625468.381056368 1.0 0.5604798622796128 0.5505350843907243 23.002261619945884 YIEVFK(ub)SHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIEVFKSHR 9 1 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 23321200.0 5832500.0 12805200.0 4683500.0 True False 4849982.173560282 12736215.845966805 5662798.195942695 1.0 2.6260335378959514 1.1675915484418657 22.209548013909828 -6.620023523842927 2.115986280871892 2.078847612132798 1.1730797012782468 0.0830943548110542 0.6992332969456871 0.5853358554603652 4.979796832360461 0.27147827822653653 0.7756187072091892 2.398702988193987e-07 6.620023523842927 -0.9057679108545511 YIEVFK(ub)SHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIEVFKSHR 9 1 P52597;A0A1B0GW42 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 65608900.0 11053200.0 16397000.0 38158700.0 True False 14308585.291145377 15484492.535878586 31214208.14132583 1.0 1.0821819362855458 2.1815020497269013 23.770377702150093 -6.921886833608185 0.8106099602316665 0.9773543862145398 2.366706348952742 0.9946892196883901 0.03925350571058323 0.09707416574883264 0.0999543791887555 0.03416334592617188 0.104256520264906 1.1970524128991166e-07 6.921886833608185 1.389351962738202 up YIEVFK(ub)SSQEEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIEVFKSSQEEVR 13 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 25446370.0 9669700.0 9394970.0 6381700.0 True False 12677070.341508014 7993277.097306237 5721382.901588981 1.0 0.630530310393102 0.4513174375041283 23.595718042802243 -13.999999999549916 0.09529715652282925 2.852697571857346 0.040176249019696235 0.9998170162514862 0.0030901830011658216 12.117886515001567 0.09094823677089027 4.4723437063239 0.3678067248801254 1.0000000010363577e-14 13.999999999549916 -2.8125213228376498 YIEVFK(ub)SSQEEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIEVFKSSQEEVR 13 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 55020500.0 2433700.0 17446000.0 35140800.0 True False 3692100.8273024117 14332624.993779868 28195205.47724024 1.0 3.881970093501435 7.6366293327478605 21.816010521295656 -6.9674934211121595 0.3123110397789009 0.43712493840320904 11.201224837633125 0.9999557047344351 0.018084168806886812 0.07712471936023274 0.011927211781158489 0.05879627525400171 0.3326041263417149 1.0777215793811241e-07 6.9674934211121595 10.764099899229917 YIEVFK(ub)SSQEEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIEVFKSSQEEVR 13 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 6657590.0 700290.0 0.0 5957300.0 True False 582322.1631071635 0.0 7202943.886556951 1.0 0.0 12.3693452574832 19.1514580030435 -6.8873198418378045 1.0381436433415376 0.2920485201590123 13.378854518444872 0.9791252773511311 0.8105574614354508 0.1213431363298287 0.23478455988912594 0.5969193418278071 1.4744218745438133 1.2962242980787376e-07 6.8873198418378045 13.08680599828586 up YIEVFK(ub)SSQEEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIEVFKSSQEEVR 13 1 P52597 P52597 HNRNPF Heterogeneous nuclear ribonucleoprotein F;Heterogeneous nuclear ribonucleoprotein F, N-terminally processed 1 62254400.0 2433700.0 15556200.0 44264500.0 True False 3150472.6253990224 14690483.795001203 36208815.192124344 1.0 4.662946021675267 11.493137537590355 21.587136843388105 -6.961391725375572 0.41535625556506384 0.6825678253167652 15.729215241618903 0.9998183796076519 0.05860146175235181 0.07920768927542425 0.019321842253998425 0.08812716834793848 0.5693207403309446 1.0929700832747112e-07 6.961391725375572 15.046647416302138 YIFDLFYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIFDLFYK 8 0 P41223-2;P41223 P41223-2 BUD31 Protein BUD31 homolog 0 10048500.0 2497800.0 3696600.0 3854100.0 False True 3274639.9887296045 3145081.6892339424 3455314.70313774 1.0 0.9604358647235832 1.0551739168366499 21.64290487596697 -6.793276013398348 1.483241521902941 0.9779813345338731 1.0562740562191593 0.8117531495107012 0.016856557855581246 0.23050485715485725 1.00171211532099 0.008943756412589094 0.02089046420025266 1.6096223236810782e-07 6.793276013398348 0.07829272168528612 YIFDLFYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIFDLFYK 8 0 P41223-2;P41223 P41223-2 BUD31 Protein BUD31 homolog 0 13058300.0 5833600.0 3864900.0 3359800.0 False True 5648415.561151192 5408174.725187237 2479767.5881605176 1.0 0.9574675706199295 0.43902003337288475 22.429414802755762 -6.923168916011604 0.8008726491142266 1.0101861168003636 0.3490020664197822 0.995016861194877 0.018001875886695395 0.09634299490036796 0.09621400402701766 0.01577666241061687 0.04879052305723434 1.1935238008633462e-07 6.923168916011604 -0.6611840503805815 down YIFDLFYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIFDLFYK 8 0 P41223-2;P41223 P41223-2 BUD31 Protein BUD31 homolog 0 14994600.0 2497800.0 4029600.0 8467200.0 False True 3421304.1605069228 3851558.9478947516 6467421.74745785 1.0 1.1257575378285218 1.890338141260026 21.70611493748986 -6.935555958061185 0.699686137531668 0.9904140019586588 2.0720923388564225 0.9975219471195111 0.01958507457933301 0.08985369102758917 0.06428818172434057 0.01847485716818071 0.06719425027711332 1.1599627474096807e-07 6.935555958061185 1.0816783368977636 YIFDLFYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIFDLFYK 8 0 P41223-2;P41223 P41223-2 BUD31 Protein BUD31 homolog 0 9528200.0 5833600.0 2028200.0 1666400.0 False True 4850896.872298545 2017273.6840338202 2014836.5354369427 1.0 0.415855817416699 0.4153534054584496 22.209820078190038 YIFDLFYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIFDLFYK 8 0 P41223-2;P41223 P41223-2 BUD31 Protein BUD31 homolog 0 9360500.0 1887300.0 3972200.0 3501000.0 False True 2443147.0542448056 3751143.5781555683 2863853.923293548 1.0 1.535373636899263 1.1721987500988909 21.220309272079877 -10.43447201982005 5.626075680363205 0.9997671706827712 1.3537861934990778 0.5585547364290919 0.1482655266756618 0.0004332783203902116 4.3552678265177387e-05 0.1436506389840305 0.04785249296929203 3.677290842030758e-11 10.43447201982005 0.3540190228163066 YIFPTLDKPSVVSLQNLIVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIFPTLDKPSVVSLQNLIVR 20 1 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 0 22769500.0 12428000.0 3809900.0 6531600.0 False True 12033479.942743257 5331212.938366032 4820778.01620014 1.0 0.44303168856661446 0.4006137907852077 23.52055057772583 -13.999999999999998 0.3652219884097742 8.52906128362779 0.39588218586896573 0.9997826093435968 0.004026702614411674 22.27190377671651 0.1957422266984906 131.00890276901237 0.012035378048354915 1.0000000000000041e-14 13.999999999999998 -8.133179097758825 YIFPTLDKPSVVSLQNLIVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIFPTLDKPSVVSLQNLIVR 20 1 V9GYM8;A0A5F9ZI21;Q92974-3;Q92974-2;Q92974 V9GYM8 ARHGEF2 Rho guanine nucleotide exchange factor 2 0 23093600.0 12428000.0 4060500.0 6605100.0 False True 10334432.653751776 4038625.280553854 7986195.871468156 1.0 0.39079312971164276 0.7727754526097642 23.300955853160108 -10.13313455796123 5.330982968619796 1.0000100035796395 0.5817842911605612 0.615130021817512 0.15594363031129893 47216722.446576804 89749561.88244013 4006.1141483911665 0.05338366077070545 7.359790329314847e-11 10.13313455796123 -0.41822571241907835 YIFTATPAK(ub)DFGGIFHTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIFTATPAKDFGGIFHTR 18 1 Q9BSG0 Q9BSG0 PRADC1 Protease-associated domain-containing protein 1 1 15001200.0 1312900.0 1929300.0 11759000.0 True False 1091734.5213317266 1918906.4779639342 14217752.532527007 1.0 1.7576676751260016 13.023085974403207 20.058190645982748 -6.920533259717269 0.8207664269530377 0.7561823681435604 14.862181014016983 0.9943276875861243 0.4140700773363196 0.09785898605801553 0.10399723791492173 0.35777465874772707 1.0772226224529458 1.200789109065648e-07 6.920533259717269 14.105998645873422 up YIFTMLSSLAR ddPTM_RPMI8226_Bortezomib_1h_R1 2 YIFTMLSSLAR 11 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 0 47387090.0 9371600.0 23971560.0 14043930.0 False True 12286258.354703492 20395096.688409023 12590798.842489095 1.0 1.6599924972765416 1.0247870815502604 23.55054228984973 -10.182752088827524 4.793375343454807 0.9999585862251611 1.3423897894148007 0.2792237843898162 0.25932152506845835 0.0001147832026058754 1.9570092194607103e-05 0.2511173027731556 0.08369566232458639 6.565199249404812e-11 10.182752088827524 0.3424312031896396 YIFTMLSSLAR ddPTM_RPMI8226_Bortezomib_2h_R1 2 YIFTMLSSLAR 11 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 0 55911800.0 19376800.0 16919400.0 19615600.0 False True 18761694.090324085 23675404.653505385 14477685.904613825 1.0 1.2619012195554042 0.7716619743885686 24.1612867663379 -6.761572905548647 1.6064429890261493 1.1518292334100653 0.769724050376141 0.6973879353005383 0.11018299478510228 0.28028754466816463 1.4259328947542758 0.054106285435866056 0.12983031129221756 1.7315183342393175e-07 6.761572905548647 -0.38210518303392427 YIFTMLSSLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIFTMLSSLAR 11 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 0 41032400.0 9202800.0 8101600.0 23728000.0 False True 13961320.414799951 6655806.18191028 19038150.39964815 1.0 0.47673185516569566 1.3636353750227244 23.734932057463887 -6.746818073907995 1.6615646629124543 0.6911495074222739 1.3649883883884901 0.6352432561179053 0.21985419069016518 0.3056007820664972 1.6589495260901068 0.10456994744469186 0.25472709024268414 1.791356096505552e-07 6.746818073907995 0.6738388809662162 YIFTMLSSLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 YIFTMLSSLAR 11 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 0 120540300.0 9371600.0 35676400.0 75492300.0 False True 12836533.777967291 34100098.681921855 57662573.552722484 1.0 2.6564880575822953 4.492067294030332 23.61375235137262 -6.969801448278739 0.26288459735871494 0.5024746708282788 6.700745718198502 0.9999807927120402 0.006250720959591507 0.07636718755104023 0.00926038998151316 0.03761602059508108 0.17245143794018708 1.0720092968260717e-07 6.969801448278739 6.198271047370223 YIFTMLSSLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 2 YIFTMLSSLAR 11 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 0 80095550.0 19376800.0 24786550.0 35932200.0 False True 16112667.737787059 24653019.935405042 43445456.88827855 1.0 1.5300396145815969 2.696354048584473 23.941692041772175 -6.958135330260671 0.4609685651690266 0.9663308229109197 3.307155101562515 0.9996946451841677 0.012382118936161864 0.08037416643561014 0.023644925193999997 0.015866097960798634 0.09633916744560359 1.1011961129675161e-07 6.958135330260671 2.3408242786515956 YIFTMLSSLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIFTMLSSLAR 11 0 P11388;P11388-2;P11388-3;P11388-4 P11388 TOP2A DNA topoisomerase 2-alpha 0 36695800.0 9202800.0 12892000.0 14601000.0 False True 11913206.014308307 12174548.86702122 11943767.81891148 1.0 1.0219372394298418 1.002565371954994 23.506058379556336 -6.61623623786504 2.1308268379464597 1.0145945042405533 1.0026380604605998 0.07018248161152363 0.00944292114022957 0.5956176204271103 5.1335782025815035 0.003648256086980295 0.010473417237895823 2.4197124672492977e-07 6.61623623786504 -0.01195644377995353 YIFTMLSTLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIFTMLSTLAR 11 0 Q02880;Q02880-2;E9PCY5 Q02880 TOP2B DNA topoisomerase 2-beta;DNA topoisomerase 2 0 9107900.0 2190500.0 5085600.0 1831800.0 False True 2871766.712832173 4326848.303513538 1642262.907866354 1.0 1.5066851649820627 0.571865012756114 21.45350712631591 -6.759511956028366 1.6143356114464242 1.2944926959663163 0.5685362741960713 0.6889468921546731 0.21309839170349584 0.28374578324108485 1.4573075959290736 0.1041579199570143 0.25042582983651324 1.7397548023247742e-07 6.759511956028366 -0.725956421770245 YIFTMLSTLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIFTMLSTLAR 11 0 Q02880;Q02880-2;E9PCY5 Q02880 TOP2B DNA topoisomerase 2-beta;DNA topoisomerase 2 0 17213000.0 6051300.0 5427500.0 5734200.0 False True 5859204.793814148 7594729.054038599 4232240.997687375 1.0 1.2962047447217975 0.7223234460341037 22.48227344593953 -6.7663913725637235 1.5880399586168308 1.1706728004216154 0.7195084469036895 0.7166751141863186 0.12472808206157399 0.2722922807039539 1.3545818221402126 0.06192719964722742 0.1479194190131572 1.712413438695517e-07 6.7663913725637235 -0.45116435351792583 YIFTMLSTLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIFTMLSTLAR 11 0 Q02880;Q02880-2;E9PCY5 Q02880 TOP2B DNA topoisomerase 2-beta;DNA topoisomerase 2 0 20678700.0 2190500.0 7431200.0 11057000.0 False True 3000387.0460366793 7102865.0123077985 8445564.326063093 1.0 2.36731625064514 2.8148249530736864 21.5167171878388 -9.930460671177947 0.28028339617773923 3.0659656007111617e-15 3.00661469242525 0.9989420689818774 0.025108906628428178 1.346405488076444 0.12426390997384659 1.2641479910638016 0.1729327577581264 1.1736519612056591e-10 9.930460671177947 3.006614692425247 YIFTMLSTLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIFTMLSTLAR 11 0 Q02880;Q02880-2;E9PCY5 Q02880 TOP2B DNA topoisomerase 2-beta;DNA topoisomerase 2 0 13403200.0 6051300.0 2557800.0 4794100.0 False True 5031924.06804378 2544020.6237164484 5796524.144586086 1.0 0.5055761154809052 1.1519498438774245 22.262678721373806 -6.70229818090848 1.8223745167776575 0.6936672106863979 1.1501259143528957 0.4284701318581029 0.20861816253001972 0.39084582181437216 2.525027361094011 0.09126498074255994 0.23407196261612895 1.984731758592436e-07 6.70229818090848 0.45645870366649777 YIGTGHADTTK(ub)WEWLVNQHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIGTGHADTTKWEWLVNQHR 20 1 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 1 8952700.0 3045000.0 2453900.0 3453800.0 True False 3992024.4878219496 2087787.6852272814 3096433.907188998 1.0 0.522989698985133 0.7756550383483278 21.928689139786655 -10.032894965160313 5.09718102729753 1.0000041247594806 0.6493223686649431 0.7197627596812434 0.10315019286071625 4.835084448528765e-06 9.174071687556487e-07 0.09987591877044999 0.033291581591410484 9.270540058154176e-11 10.032894965160313 -0.35068175609453756 YIGTGHADTTK(ub)WEWLVNQHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIGTGHADTTKWEWLVNQHR 20 1 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 1 21944000.0 8694400.0 8435700.0 4813900.0 True False 8418401.031073945 11804119.001594357 3552995.17609558 1.0 1.402180646659986 0.42205107157294935 23.005114806938604 -6.795311370826819 1.4752525438237942 1.2232364643935263 0.4100765598688832 0.8180179856326516 0.17160799679646394 0.22752171985226682 0.9780456671927379 0.09153947212847163 0.21349808648422539 1.602096343321502e-07 6.795311370826819 -0.8131599045246432 down YIGTGHADTTK(ub)WEWLVNQHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIGTGHADTTKWEWLVNQHR 20 1 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 1 110257900.0 47232000.0 47511000.0 15514900.0 True False 61142755.081910945 44866971.084474474 12691347.396317353 1.0 0.7338068267347074 0.20756911230635863 25.86567822548873 -7.139495922329552 0.48612654944207095 1.0121397217038766 3.629048142423271e-21 0.9994391619758177 0.007797628631850398 0.0803223886556371 0.0308939025107061 0.009242345173951698 0.043459712394002425 7.252772878205946e-08 7.139495922329552 -1.0121397217038766 down YIHLENLLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIHLENLLAR 10 0 Q2TAY7 Q2TAY7 SMU1 WD40 repeat-containing protein SMU1;WD40 repeat-containing protein SMU1, N-terminally processed 0 13801000.0 5334600.0 3722500.0 4743900.0 False True 6993712.260339881 3167117.5101913554 4253046.734702035 1.0 0.45285213235773575 0.6081243517581241 22.737627010324033 -10.668115057494676 10.132249664227828 1.0002036598293245 0.5304882420579822 0.9241915146296745 0.06338961812673839 0.0002917493927270987 9.556360930401978e-06 0.06140197002791146 0.02045891127727546 2.1472615254763614e-11 10.668115057494676 -0.4697154177713423 YIHLENLLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIHLENLLAR 10 0 Q2TAY7 Q2TAY7 SMU1 WD40 repeat-containing protein SMU1;WD40 repeat-containing protein SMU1, N-terminally processed 0 21002500.0 9291200.0 2762000.0 8949300.0 False True 8996255.94174574 3864881.00363972 6605209.856754845 1.0 0.42960994314371775 0.7342176455990305 23.100893275419317 -10.079457064729398 5.2945005155716345 1.0000055905018215 0.5819137943709118 0.7152474288521583 0.12435557379117568 8.206370335002384e-06 1.4267231698278478e-06 0.12040837541007955 0.04013558885820008 8.328042547047889e-11 10.079457064729398 -0.41809179613090963 YIHLENLLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIHLENLLAR 10 0 Q2TAY7 Q2TAY7 SMU1 WD40 repeat-containing protein SMU1;WD40 repeat-containing protein SMU1, N-terminally processed 0 22927000.0 5334600.0 6955200.0 10637200.0 False True 7306945.782144383 6647896.266229309 8124912.440010712 1.0 0.9098050628040022 1.1119437152339564 22.800837071846924 -6.78537983178226 1.5145062420507471 0.9492860941184816 1.1138352594871554 0.7860883159336716 0.03824082920080142 0.24230533209328511 1.0979499956074712 0.019879201090837344 0.04670817878663076 1.6391555488615173e-07 6.78537983178226 0.1645491653686738 YIHLENLLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIHLENLLAR 10 0 Q2TAY7 Q2TAY7 SMU1 WD40 repeat-containing protein SMU1;WD40 repeat-containing protein SMU1, N-terminally processed 0 15735600.0 9291200.0 2568200.0 3876200.0 False True 7726044.469949986 2554364.5968522155 4686695.498476163 1.0 0.33061738212707326 0.6066099563243261 22.881298550853593 -10.394335326857632 5.959706209365421 1.000130565027705 0.4686136692258629 0.831726463644818 0.11267349659675051 0.0001955153210835021 1.9869539633562427e-05 0.1091220972430076 0.03636521465651423 4.033338511314426e-11 10.394335326857632 -0.5315168958018421 YIHLENLLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIHLENLLAR 10 0 Q2TAY7 Q2TAY7 SMU1 WD40 repeat-containing protein SMU1;WD40 repeat-containing protein SMU1, N-terminally processed 0 9315800.0 2908000.0 4115900.0 2291900.0 False True 3764463.325249768 3886846.546833118 1874797.7168798896 1.0 1.0325101378362427 0.49802523092863415 21.844012773347927 -6.892431048767195 1.0078694531709067 1.0270671982732744 0.4498000640404934 0.9824099468693978 0.03244813269227612 0.1171936727764864 0.21049321050295 0.02444871106195383 0.06151070965006728 1.2810584670236106e-07 6.892431048767195 -0.5772671342327811 down YIHSAGVVHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIHSAGVVHR 10 0 O15264;O15264-2;Q5R3E6 O15264 MAPK13 Mitogen-activated protein kinase 13 0 4872460.0 977060.0 1967500.0 1927900.0 False True 1280935.1218624997 1673956.669254934 1728419.401722644 1.0 1.3068239293969663 1.3493418770573604 20.28876597573164 -12.458660051489046 0.30438431956588696 7.996308020496163e-08 1.3599288551522664 0.9995481458060105 0.0033082169411671543 6.813418120905509 0.16958512765615108 4.248446099802094 0.015079240581606802 3.478083054767014e-13 12.458660051489046 1.3599287751891862 YIHSAGVVHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIHSAGVVHR 10 0 O15264;O15264-2;Q5R3E6 O15264 MAPK13 Mitogen-activated protein kinase 13 0 2716790.0 743700.0 507090.0 1466000.0 False True 720091.6505807991 709573.6814394152 1082010.6209427118 1.0 0.9853935688146078 1.502601259256377 19.45782101352451 -6.900403545663986 0.9587340991228401 0.9787332543857209 1.5573338637822522 0.9867651292248701 0.027661517739015106 0.1111088446384132 0.17575941881231583 0.021623091701196414 0.05637304578624858 1.2577561638452195e-07 6.900403545663986 0.5786006093965314 YIHSAGVVHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIHSAGVVHR 10 0 O15264;O15264-2;Q5R3E6 O15264 MAPK13 Mitogen-activated protein kinase 13 0 4185160.0 977060.0 1488300.0 1719800.0 False True 1338305.4860536868 1422541.9848500516 1313618.6603928125 1.0 1.0629426537320386 0.981553669234616 20.35197603725453 -6.700202382661046 1.8300000483176553 1.0390769656160008 0.9817937565437066 0.4185838060122331 0.026567892533617677 0.39511362536698486 2.572590604233128 0.011581132008772293 0.029777819322497314 1.994332732759931e-07 6.700202382661046 -0.05728320907229423 YIHSAGVVHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIHSAGVVHR 10 0 O15264;O15264-2;Q5R3E6 O15264 MAPK13 Mitogen-activated protein kinase 13 0 1954030.0 743700.0 697590.0 512740.0 False True 618419.5014962347 693831.9442092266 619951.5633581007 1.0 1.1219438302487799 1.0024773828415166 19.238226288958785 -6.641380157286926 2.03911909747947 1.0796593997630493 1.0029720250579168 0.16002939874730948 0.052157904994217616 0.5299156130585861 4.212719763822333 0.020815874118272022 0.05776897040451126 2.2835989924188703e-07 6.641380157286926 -0.07668737470513243 YIHSAGVVHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIHSAGVVHR 10 0 O15264;O15264-2;Q5R3E6 O15264 MAPK13 Mitogen-activated protein kinase 13 0 2520110.0 905610.0 414900.0 1199600.0 False True 1172329.9972418996 391810.4502735884 981285.10893543 1.0 0.33421515374970134 0.8370383008573231 20.160947298104695 -9.977928301435119 6.732761522717331 1.0000000544536176 0.5856267273036996 0.47520521266196214 0.20527669021235428 1.6770792051467163e-07 2.5514100811218176e-08 0.19875832729467588 0.06625276687975105 1.0521355586986072e-10 9.977928301435119 -0.41437332714991804 YIINVK(ub)QFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIINVKQFAK 10 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 66767000.0 19810000.0 29462000.0 17495000.0 True False 25971101.840312906 25066384.441976503 15684785.223890088 1.0 0.9651644584084577 0.6039322212946632 24.63040388676981 -6.925610695604641 0.7819836767455993 1.0064778604098086 0.5374341285352403 0.9956029293284687 0.011873737915551732 0.0949819722708559 0.08932190587774466 0.010547303388541445 0.03350870679050302 1.1868321555288455e-07 6.925610695604641 -0.46904373187456827 YIINVK(ub)QFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIINVKQFAK 10 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 137907000.0 43123000.0 47790000.0 46994000.0 True False 41754083.96933682 66872796.2215576 34684861.61021952 1.0 1.601586955438116 0.8306938702257541 25.315413978783983 -6.698463208187487 1.8361539188722709 1.3741167598045845 0.8330369605587078 0.41038195509866515 0.25400872779085004 0.3987249769415547 2.612354453746375 0.11040317412256878 0.284488398303314 2.0023352447953382e-07 6.698463208187487 -0.5410797992458767 YIINVK(ub)QFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIINVKQFAK 10 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 220007000.0 73896000.0 62651000.0 83460000.0 True False 112105634.52123892 51470439.555502765 66964094.41818255 1.0 0.4591244657354975 0.5973303188921865 26.740283550101857 -10.258317185157225 8.354682246090386 1.000000300060257 0.5282273923139283 0.9395274644726308 0.056422303283317966 3.1536162379302475e-07 2.8062067079051e-08 0.05463069443144776 0.018210220080912883 5.5167437903816074e-11 10.258317185157225 -0.47177290774632874 YIINVK(ub)QFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIINVKQFAK 10 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 79041000.0 19810000.0 25740000.0 33491000.0 True False 27134292.34512061 24602721.689202633 25581115.568796188 1.0 0.9067021677322935 0.9427596357933499 24.6936139482927 -10.384794786077224 7.52770944299158 1.0000017600727713 0.92473090190599 0.8531587108699552 0.014720399694381603 4.3483171640869235e-07 3.555112587871005e-08 0.014253298943973428 0.004750988572154729 4.122922904686223e-11 10.384794786077224 -0.07527085816678125 YIINVK(ub)QFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIINVKQFAK 10 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 113000000.0 43123000.0 46297000.0 23580000.0 True False 35858685.17281447 46047588.871765 28510468.97839842 1.0 1.2841404711256685 0.7950784821305452 25.09581925421826 -6.74923174178992 1.6530686406349167 1.1672340587030134 0.7941853069728229 0.6455175620580941 0.11939236567038676 0.30137965059072674 1.6201851114763068 0.05706487892464188 0.13862935504396665 1.781427934592875e-07 6.74923174178992 -0.3730487517301906 YIINVK(ub)QFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIINVKQFAK 10 1 P35998;C9JLS9 P35998 PSMC2 26S protease regulatory subunit 7 1 197266000.0 73896000.0 59872000.0 63498000.0 True False 95659828.70792878 56540070.56828216 51942015.54449987 1.0 0.5910534372888316 0.542986708695566 26.511409872194307 -13.999999999999998 0.3021037360303618 4.775748274046421 0.5314156332898428 0.9996545190396787 0.003811280814004011 16.726794195828408 0.17462025108877158 39.52508695708373 0.017215386948525556 1.0000000000000041e-14 13.999999999999998 -4.2443326407565785 YIK(ub)MFVLDEADEMLSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIKMFVLDEADEMLSR 16 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 7897700.0 3378000.0 1837400.0 2682300.0 True False 3270767.239023719 2571083.401914418 1979725.162724852 1.0 0.7860795996849512 0.605278522759013 21.64119766440538 -6.973071981685806 0.16944194096177767 1.1609469845959006 0.22557189595005542 0.9999974975508111 0.0002551500140804054 0.07531795632817327 0.0052821430771421264 0.007658650850223819 0.020986606856217983 1.0639666575657344e-07 6.973071981685806 -0.9353750886458452 YIK(ub)MFVLDEADEMLSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIKMFVLDEADEMLSR 16 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 55195200.0 4201800.0 8181400.0 42812000.0 True False 6374437.792726825 6721365.248430047 34350189.4348338 1.0 1.0544247927400066 5.388740239025793 22.603866675309476 -6.909639572070605 0.8981856145692624 0.8642665032070992 5.944581156769919 0.9907848488367762 0.19738265277786782 0.10465684129526134 0.14006356122809105 0.16131239080569146 0.4441911260284383 1.2312902143191956e-07 6.909639572070605 5.08031465356282 up YIK(ub)MFVLDEADEMLSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIKMFVLDEADEMLSR 16 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 5795400.0 3378000.0 1092600.0 1324800.0 True False 2808956.6707735397 1086713.94693588 1601809.5548168889 1.0 0.38687458523047175 0.5702507167459359 21.421602939839655 -10.397152959183623 5.129863288766745 1.00042138515499 0.47856265098818285 0.9151172661672805 0.07486299220317226 0.0003610720468865492 4.243209762140417e-05 0.07254253827158569 0.024161926837496375 4.007255566136262e-11 10.397152959183623 -0.5218587341668071 YIK(ub)MFVLDEADEMLSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIKMFVLDEADEMLSR 16 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 34768900.0 4201800.0 4124100.0 26443000.0 True False 5439312.929860547 3894590.209624744 21630645.328092366 1.0 0.7160077494796008 3.976723826523239 22.374992997401925 -6.885692017415737 1.0475583285813816 0.8062792707731482 4.2345750402795295 0.9779935565244293 0.21877178567013852 0.1227069333926461 0.2428377225608566 0.15996008789645813 0.3930645986913993 1.3010919282367273e-07 6.885692017415737 3.428295769506381 up YIK(ub)YNSNSGFVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIKYNSNSGFVR 12 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 5852400.0 1730600.0 2011100.0 2110700.0 True False 1675663.0502825447 2814142.717747954 1557844.350357285 1.0 1.6794204045219252 0.9296883106031409 20.676300644042662 -6.668132122485959 1.9443291135512633 1.434381699880591 0.9327670309004641 0.27061010449640155 0.28873091223476127 0.46544978783153385 3.390616343991906 0.11963586184162193 0.3203785726021378 2.147177153510256e-07 6.668132122485959 -0.5016146689801269 YIK(ub)YNSNSGFVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIKYNSNSGFVR 12 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 14067500.0 2166500.0 1847000.0 10054000.0 True False 3286738.89236581 1517388.4193231321 8066822.493175264 1.0 0.46166990108268346 2.4543545311470507 21.64822541860775 -6.834767156899138 1.3064601909541957 0.713161726853385 2.5133959808446753 0.9150798103621945 0.24527284501137703 0.1750003517779855 0.5824631473954908 0.14732562015505712 0.33908285366602897 1.462961317853728e-07 6.834767156899138 1.8002342539912903 up YIK(ub)YNSNSGFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIKYNSNSGFVR 12 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 3895800.0 1430500.0 1465100.0 1000200.0 True False 1959394.5078089368 1400367.037562191 763973.3597656072 1.0 0.7146937648243846 0.3899027769654763 20.901976470839035 -6.969436190548121 0.2713173228868946 1.0794622212304439 0.01535293614762093 0.9999776434776319 0.0011784829388587464 0.0764860989792612 0.009683106544308304 0.006315694464187332 0.030152950149690414 1.072911275560652e-07 6.969436190548121 -1.0641092850828229 down YIK(ub)YNSNSGFVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIKYNSNSGFVR 12 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 6431300.0 1730600.0 3210300.0 1490400.0 True False 1439070.5785792412 3193005.47670534 1802035.7491689997 1.0 2.2187969959456164 1.2522219382374595 20.45670591947694 -10.307041929075787 4.883213804067193 0.999696103394744 1.7355094670920097 0.43568108748258383 0.39460261491599374 0.001306072924447079 0.0001853406830167835 0.38222565685069837 0.12735744632806298 4.931261926577658e-11 10.307041929075787 0.7358133636972657 YIK(ub)YNSNSGFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIKYNSNSGFVR 12 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 11047000.0 2166500.0 1826600.0 7053900.0 True False 2804576.958099593 1724948.1042895562 5770162.579126076 1.0 0.615047520556682 2.0574092511392488 21.4193517407002 -6.835694423473219 1.302221674840285 0.794968638896587 2.1009518243574865 0.9167985317309545 0.17589491614226235 0.1738877156315378 0.574644766384454 0.10598359733154523 0.24395822416318413 1.4598410664609924e-07 6.835694423473219 1.3059831854608994 up YILAATLDNTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YILAATLDNTLK 12 0 P61964 P61964 WDR5 WD repeat-containing protein 5 0 7841800.0 2318900.0 4654900.0 868000.0 False True 3040100.356259543 3960407.0646580853 778187.6864439321 1.0 1.3027224764155032 0.2559743413870038 21.535687518351004 -6.829339210297571 1.3308130852442999 1.1618309861892697 0.22817564842874144 0.9045577170228953 0.13587378076562812 0.1816260148562159 0.6293310736228415 0.0801682190196032 0.1844993785386866 1.4813606008100817e-07 6.829339210297571 -0.9336553377605283 down YILAATLDNTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YILAATLDNTLK 12 0 P61964 P61964 WDR5 WD repeat-containing protein 5 0 10609400.0 3940400.0 2825300.0 3843700.0 False True 3815314.1588659124 3953457.0237448635 2836919.661471689 1.0 1.0362074678851645 0.743561222836484 21.863370425015 -6.875913826157049 1.102293023277938 1.021430643929618 0.7243772001910115 0.9702392179502346 0.022471902009429768 0.13131319062559973 0.2946590823116027 0.015757215522182275 0.03774072305731688 1.3307184364038619e-07 6.875913826157049 -0.2970534437386064 YILAATLDNTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YILAATLDNTLK 12 0 P61964 P61964 WDR5 WD repeat-containing protein 5 0 9062400.0 2318900.0 3417400.0 3326100.0 False True 3176259.9959162106 3266407.968169434 2540543.68317975 1.0 1.0283817988354633 0.7998538175231829 21.598897579873896 -6.875786425842775 1.1029904835278461 1.0167782720023106 0.7849095147580825 0.9701265985196522 0.017578037259661818 0.13142980716668642 0.295375936312458 0.012319085818332043 0.029497670111991746 1.3311088600055943e-07 6.875786425842775 -0.23186875724422817 YILAATLDNTLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YILAATLDNTLK 12 0 P61964 P61964 WDR5 WD repeat-containing protein 5 0 9059700.0 3940400.0 1942100.0 3177200.0 False True 3276617.1893179533 1931637.5218233303 3841537.8302870025 1.0 0.5895218788818635 1.1724097165853666 21.643775700449275 -6.717488181700523 1.7686399574113907 0.749601316073061 1.1713588655170983 0.5005463808168473 0.17278563311612694 0.36020129122296246 2.2006910910073767 0.07761715109908099 0.1954049994008075 1.9165132154103454e-07 6.717488181700523 0.4217575494440373 YILVTGGVISGIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YILVTGGVISGIGK 14 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9;Q9NRF8 A0A3B3IRI2 CTPS1;CTPS2 CTP synthase 1;CTP synthase 2 0 12187500.0 4196300.0 4672200.0 3319000.0 False True 5501389.937027012 3975125.972092955 2975581.718096091 1.0 0.7225675724853526 0.540878169363889 22.391364733764895 -8.513760149980222 0.10617868395323356 1.5443423165575412 1.7223710488867874e-09 0.9999733265139898 0.000975011379104453 0.15672062682382704 0.02601391213776871 0.18916441004009127 0.16898263710004643 3.063654946838556e-09 8.513760149980222 -1.54434231483517 YILVTGGVISGIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YILVTGGVISGIGK 14 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9;Q9NRF8 A0A3B3IRI2 CTPS1;CTPS2 CTP synthase 1;CTP synthase 2 0 23651600.0 8532700.0 7757700.0 7361200.0 False True 8261834.109063847 10855390.065871058 5433080.888733613 1.0 1.313920120226317 0.6576119560150837 22.97803066166131 -6.776631922234573 1.5488341067253537 1.1785305021273775 0.6529390098964709 0.7553155139230988 0.13257802363759863 0.25585977164333856 1.2120484022839153 0.06743344254242557 0.15957895489349144 1.6725075147151922e-07 6.776631922234573 -0.5255914922309066 YILVTGGVISGIGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YILVTGGVISGIGK 14 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9;Q9NRF8 A0A3B3IRI2 CTPS1;CTPS2 CTP synthase 1;CTP synthase 2 0 92683000.0 20367000.0 40924000.0 31392000.0 False True 30898228.027147282 33620792.45932861 25187357.440397624 1.0 1.0881139342291497 0.8151715825991035 24.88102076804509 -6.819830451914558 1.3728337689589896 1.0475002257602868 0.8092456488195894 0.8839402885638392 0.038747093615490065 0.1937059008113191 0.7174286786043966 0.022180733298431458 0.051119679500302204 1.5141522564306546e-07 6.819830451914558 -0.2382545769406974 YILVTGGVISGIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YILVTGGVISGIGK 14 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9;Q9NRF8 A0A3B3IRI2 CTPS1;CTPS2 CTP synthase 1;CTP synthase 2 0 17748600.0 4196300.0 4834300.0 8718000.0 False True 5747785.510743547 4620704.641107708 6658987.952845989 1.0 0.803910416015152 1.15853104476485 22.454574795287787 -6.756617510533983 1.625371004513008 0.8856213812232957 1.1596069104494515 0.6769416634491513 0.08244024407176864 0.2886375662047134 1.5020908145675007 0.040036048472809796 0.09653056905647131 1.7513884828914414e-07 6.756617510533983 0.2739855292261558 YILVTGGVISGIGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YILVTGGVISGIGK 14 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9;Q9NRF8 A0A3B3IRI2 CTPS1;CTPS2 CTP synthase 1;CTP synthase 2 0 17924400.0 8532700.0 4031000.0 5360700.0 False True 7095318.112702596 4009284.202909146 6481597.584923685 1.0 0.5650605285380244 0.9135034514266273 22.758435937095587 -9.902529080571284 6.573127999816394 1.0000000159350784 0.7392819899823168 0.4274193458278267 0.142251227593537 3.316161554771125e-08 5.620335498126983e-09 0.13773416707140562 0.045911386287272586 1.2516154614412158e-10 9.902529080571284 -0.2607180259527616 YILVTGGVISGIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YILVTGGVISGIGK 14 0 A0A3B3IRI2;P17812;A0A3B3IRQ8;A0A3B3ITF6;A0A3B3ITB8;A0A3B3ITH9;Q9NRF8 A0A3B3IRI2 CTPS1;CTPS2 CTP synthase 1;CTP synthase 2 0 77465000.0 20367000.0 37021000.0 20077000.0 False True 26365482.993590824 34960748.8059255 16423192.007416356 1.0 1.3260044890671678 0.6229050312261931 24.65214709013754 -6.780618119150053 1.5333927393693363 1.184442501218587 0.6172199164808925 0.7695985161753145 0.13790043229657686 0.24961272249173885 1.1592941934984096 0.07082821354237746 0.16704355661035333 1.6572265440771274e-07 6.780618119150053 -0.5672225847376946 YIMIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIMIFR 6 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 26715900.0 8561500.0 6733400.0 11421000.0 False True 11224209.40968393 5728802.966587626 10239264.477967916 1.0 0.5103970139442496 0.912248168600077 23.420110494844195 -10.001223310827742 7.059104441929483 1.000000025700634 0.7113225912721637 0.4076082097464059 0.1640550469091718 6.638579560054577e-08 9.388665066824866e-09 0.15884563033700172 0.05294853871170814 9.971871861188482e-11 10.001223310827742 -0.2886774344284704 YIMIFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIMIFR 6 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 14204400.0 5074900.0 2122000.0 7007500.0 False True 4913800.077359818 2969325.6660838104 5172025.529506172 1.0 0.6042829621345172 1.0525510700641079 22.228407730795325 -6.673721265908121 1.9248449879804495 0.7482197981594213 1.0507457086191754 0.29539876822204136 0.1679504999556772 0.4525966325622026 3.2365159690403114 0.07016756119198134 0.18652000813678335 2.119721154805624e-07 6.673721265908121 0.3025259104597541 YIMIFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIMIFR 6 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 11283000.0 4869300.0 2411800.0 4001900.0 False True 7387084.093513427 1981395.446520593 3210922.710904917 1.0 0.2682242981720554 0.4346671393282794 22.816573570503802 -10.440121788125072 9.031917844705825 1.0000056907867994 0.3514457187678107 0.9529283838582593 0.06795000536197675 7.786662455231278e-06 4.826598536502332e-07 0.06579288581706269 0.021930769928470054 3.6297625196598665e-11 10.440121788125072 -0.6485599720189886 YIMIFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIMIFR 6 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 24342000.0 8561500.0 7661900.0 8118600.0 False True 11726917.915837951 7323371.923484925 6201153.887815495 1.0 0.6244924690394774 0.5287965629434859 23.483320556367087 -13.999999999999998 0.19196067975796025 3.026768940214135 0.46148145514475075 0.9994884486496276 0.004599483251106027 12.383343013722545 0.138942558107452 9.394117032156409 0.06479988351237524 1.0000000000000041e-14 13.999999999999998 -2.5652874850693843 YIMIFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIMIFR 6 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 14201600.0 5074900.0 4307000.0 4819700.0 False True 4220004.206189647 4283797.33612744 5827476.986225057 1.0 1.015116840368127 1.3809173407167856 22.0088130062296 -6.915591874153865 0.8567879603916192 0.990576972614029 1.4343125975151712 0.992866094165954 0.01487478676485492 0.10083538249805478 0.11956989140010112 0.012525479412960382 0.036074296690743364 1.214529661902347e-07 6.915591874153865 0.44373562490114216 YIMIFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIMIFR 6 0 P55060-3;P55060;P55060-4 P55060-3 CSE1L Exportin-2 0 16976500.0 4869300.0 6696900.0 5410300.0 False True 6303404.838252642 6324211.627951773 4425680.914365927 1.0 1.0033008810687303 0.7021095785421206 22.58769989259625 -6.904421926264785 0.9328791361274493 1.011048934967933 0.6674937251459269 0.9886410206549929 0.015050094188240984 0.10822349769790492 0.15962760245398291 0.011991517086312117 0.03195270782600582 1.2461722432875244e-07 6.904421926264785 -0.34355520982200616 YINENLIVNTDELGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YINENLIVNTDELGR 15 0 P17987;E7ERF2;F5H136;F5H7Y1 P17987 TCP1 T-complex protein 1 subunit alpha 0 6610800.0 1386000.0 2968400.0 2256400.0 False True 1817059.422043091 2525526.2907325733 2022929.3729171522 1.0 1.3898974684564176 1.1132984141171247 20.79317416913017 -10.10534116057501 4.630607779500238 0.9999818910660325 1.2515979412921268 0.5245324735603489 0.11292109109624601 2.1112425845538367e-05 4.0790937979758945e-06 0.10934324182654416 0.036445125435025684 7.846190339897581e-11 10.10534116057501 0.25161605022609423 YINENLIVNTDELGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YINENLIVNTDELGR 15 0 P17987;E7ERF2;F5H136;F5H7Y1 P17987 TCP1 T-complex protein 1 subunit alpha 0 31860300.0 8648200.0 4406100.0 18806000.0 False True 8373667.62478534 6165478.707507954 13880144.432093205 1.0 0.7362936987442233 1.6575943844497916 22.99742822377802 -6.830183608077319 1.3270115648797323 0.8591072804547555 1.6824920912658785 0.9062518381579623 0.11861790257408115 0.180587900845129 0.6218645757943405 0.07018036504631608 0.1615105380390537 1.478483192916785e-07 6.830183608077319 0.823384810811123 YINENLIVNTDELGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YINENLIVNTDELGR 15 0 P17987;E7ERF2;F5H136;F5H7Y1 P17987 TCP1 T-complex protein 1 subunit alpha 0 107358900.0 6204900.0 88621000.0 12533000.0 False True 9413286.93895252 72805890.1509667 10055847.056590948 1.0 7.734374891908724 1.0682609721562286 23.166267141641818 -6.643810908038165 2.030594829385013 5.391094278117554 1.096090641445106 0.16939998344909257 2.878705639401314 0.5238369598197155 4.132646699214884 1.1525863186401781 3.1880641959071254 2.2708533669794067e-07 6.643810908038165 -4.2950036366724476 YINENLIVNTDELGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YINENLIVNTDELGR 15 0 P17987;E7ERF2;F5H136;F5H7Y1 P17987 TCP1 T-complex protein 1 subunit alpha 0 3046300.0 1386000.0 1660300.0 0.0 False True 1898441.655241651 1586942.456122113 0.0 1.0 0.835918476472806 0.0 20.856384230653063 -7.19753525641656 0.8946233389837216 0.9908950088185934 9.954209562538886e-20 0.9893694994648524 0.04514774248742322 0.09255112172080075 0.14083686615917373 0.03802865926569858 0.06676310659580842 6.345483856817479e-08 7.19753525641656 -0.9908950088185934 down YINENLIVNTDELGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YINENLIVNTDELGR 15 0 P17987;E7ERF2;F5H136;F5H7Y1 P17987 TCP1 T-complex protein 1 subunit alpha 0 19750600.0 8648200.0 6411600.0 4690800.0 False True 7191361.480220155 6377059.438197042 5671624.59219131 1.0 0.8867666374075547 0.7886718819226537 22.777833499212296 -6.97280272744028 0.17899885824659323 1.0768460466085514 0.5959424550656178 0.999996793337811 0.00015451706011081263 0.07540335312896754 0.005638689343366253 0.0038111781771094618 0.011042107969669769 1.0646265010020044e-07 6.97280272744028 -0.4809035915429336 YINENLIVNTDELGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YINENLIVNTDELGR 15 0 P17987;E7ERF2;F5H136;F5H7Y1 P17987 TCP1 T-complex protein 1 subunit alpha 0 33432900.0 6204900.0 15689000.0 11539000.0 False True 8032365.366864612 14815893.358260615 9439020.400138322 1.0 1.8445243314478252 1.1751233875735398 22.937393463734267 -10.23911676403546 4.792824235508449 0.999885024929155 1.5098238595116609 0.43611269313570644 0.27328179097543487 192847928.63406223 49.68486002292078 244716.34003777392 0.09355162591984215 5.7661141530814224e-11 10.23911676403546 0.5099388345825059 YINLK(ub)ASEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YINLKASEK 9 1 Q12874 Q12874 SF3A3 Splicing factor 3A subunit 3 1 18881900.0 5038600.0 5753500.0 8089800.0 True False 6522567.025654567 5433312.667267027 6617539.408357663 1.0 0.8330021977385156 1.0145605836367109 22.637008433523302 -13.865423226133034 18.44879956107671 9.077384939933864 0.931403251618852 0.0 0.08426826836865667 0.0 0.0 0.0 0.024539621291154997 1.3632539787126493e-14 13.865423226133034 -8.145981688315013 YIPFTHGK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIPFTHGKR 9 1 O15258 O15258 RER1 Protein RER1 1 2078500.0 564850.0 723880.0 789770.0 True False 740523.8200151817 615879.9256621402 708052.176408784 1.0 0.8316814517182093 0.9561504400955908 19.49818661706109 -10.383587878102372 5.049451886697062 1.0000818659276443 0.8939159459184747 0.4920087691567059 0.05081425172087237 4.686760266089907e-05 5.721379222066337e-06 0.0492386127658187 0.016400229222071797 4.134396476898244e-11 10.383587878102372 -0.10616592000916958 YIPFTHGK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIPFTHGKR 9 1 O15258 O15258 RER1 Protein RER1 1 9748720.0 950420.0 4818800.0 3979500.0 True False 1441856.6250091481 3958847.490543757 3192950.0807231846 1.0 2.7456596043442527 2.2144712763676666 20.459496282673978 -9.792341557595766 6.723592135112862 0.9999999894840363 2.4800654403561087 0.9119059596606529 0.21685672681133644 3.7063811954330094e-08 6.049516118963765e-09 0.20997062286309423 0.06999020762103364 1.6130894187645078e-10 9.792341557595766 1.4800654508720723 YIPFTHGK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIPFTHGKR 9 1 O15258 O15258 RER1 Protein RER1 1 7454320.0 950420.0 3130600.0 3373300.0 True False 1230337.425579054 2956379.357981429 2759394.0129809007 1.0 2.402901266366029 2.24279450142078 20.230622604766427 -10.127251609736902 4.636629001713811 0.9998811777105181 2.3228478839150486 0.9891328553838634 0.06536331315459151 8.029270467430781e-05 1.5113212891846971e-05 0.06329333469512287 0.02109591859793854 7.460164264583099e-11 10.127251609736902 1.3229667062045305 YIQELWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIQELWR 7 0 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 21589100.0 5618000.0 5806100.0 10165000.0 False True 7365252.404789395 4939852.512000541 9113223.30956517 1.0 0.6706969755426587 1.237326680568221 22.81230353611936 -6.7491295220273875 1.6530195991548293 0.8061733662183631 1.2383852205929116 0.6453239573941602 0.1383688945998679 0.3015209569426012 1.6207423604272841 0.06613242788626104 0.16070161529169785 1.7818472781023786e-07 6.7491295220273875 0.43221185437454845 YIQELWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIQELWR 7 0 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 11233300.0 4949000.0 2440600.0 3843700.0 False True 4791896.703945644 3415144.307560866 2836919.661471689 1.0 0.7126915537951473 0.5920243771398018 22.192165378470996 -13.999999999556474 0.11882248254113133 2.370633878612278 0.3963408015749906 0.9996987382581254 0.0029701754359864043 11.968377900227093 0.10593240136099719 3.879882667203546 0.1736368230122046 1.0000000010212566e-14 13.999999999556474 -1.9742930770372873 YIQELWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIQELWR 7 0 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 10488600.0 4949000.0 3177900.0 2361700.0 False True 4115312.777873963 3160780.021936236 2855520.550732976 1.0 0.7680534123506272 0.693876918927213 21.972570653905272 -13.999999999999998 0.1595090182382927 2.1411269619064304 0.6205612946142682 0.9995376659858445 0.002803622294047901 12.006448690947284 0.1261951048200204 4.238988406059315 0.0667797059154208 1.0000000000000041e-14 13.999999999999998 -1.5205656672921621 YIQELWR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIQELWR 7 0 P61313;A0A2R8YEM3;E7EQV9;E7ENU7;E7EX53;A0A2R8Y738;P61313-2 P61313 RPL15 60S ribosomal protein L15;Ribosomal protein L15 0 15389900.0 4792200.0 5950400.0 4647300.0 False True 6203597.36838444 5619255.00917802 3801539.0853247964 1.0 0.9058058857616357 0.612795908499588 22.564673623608414 -6.9506331184492955 0.5518479133495017 1.004008556144054 0.5007843238538852 0.9992500435518186 0.004515157618593823 0.08323248134672233 0.03491771953336155 0.004889091339391884 0.02431626121867044 1.1203839572668451e-07 6.9506331184492955 -0.5032242322901688 YIQQTK(ub)PLTLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIQQTKPLTLER 12 1 O43809 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 1 48525000.0 19406000.0 18594000.0 10525000.0 True False 18789967.15230734 26018681.166429035 7768186.756768107 1.0 1.3847113704631484 0.41342205091690126 24.163459208923484 -6.799239185717641 1.4589742179610956 1.2124716156067943 0.40025841091114533 0.8299320965596936 0.16469803474709416 0.22185056870830755 0.9323739860542867 0.0888093523761163 0.2066382049400366 1.5876721045506753e-07 6.799239185717641 -0.812213204695649 down YIQQTK(ub)PLTLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 YIQQTKPLTLER 12 1 O43809 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 1 48710700.0 17430000.0 8973700.0 22307000.0 True False 26442584.303686175 7372273.12316188 17898011.67249458 1.0 0.27880304884323137 0.6768631789896399 24.65635984634893 -10.762035532820232 6.840424215662429 1.0123035778969784 0.4778331139184102 0.6964501573302058 0.1625073676340941 0.03008060800548804 0.0010464419596076062 0.15522295333734856 0.05244902737357103 1.7296748360277405e-11 10.762035532820232 -0.5344704639785682 YIQQTK(ub)PLTLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIQQTKPLTLER 12 1 O43809 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 1 51278100.0 19406000.0 28002000.0 3870100.0 True False 16136948.831566378 27851147.668038156 4679320.016679379 1.0 1.7259240243457292 0.2899755130614223 23.94386448435776 -6.769247923049233 1.57712875033357 1.4167673166418393 0.28208883782683436 0.727748820482643 0.30588416947759106 0.26764773650127444 1.3136944774909989 0.15288026917713937 0.3642003398070357 1.701187084822573e-07 6.769247923049233 -1.134678478815005 YIQQTK(ub)PLTLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YIQQTKPLTLER 12 1 O43809 O43809 NUDT21 Cleavage and polyadenylation specificity factor subunit 5 1 36251400.0 17430000.0 11719000.0 7102400.0 True False 22563478.596665557 11066827.348171083 5809836.0767781 1.0 0.49047522972838703 0.2574884919400983 24.42748616844138 -10.390931376246332 0.17241270896005897 1.784534094268401 1.1673567887729168e-14 0.9995689034782019 0.006437681988848303 2.099696250460705 0.08702039523262133 0.8836573257487009 0.17209529723628236 4.065075571759025e-11 10.390931376246332 -1.7845340942683892 YISAAPGAEAK(ub)YR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YISAAPGAEAKYR 13 1 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72;H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;H0YDK8 A0A0C4DG68;H0YEH2 PUM2;PUM1 Pumilio homolog 2;Pumilio homolog 1 1 7573100.0 2488200.0 3213000.0 1871900.0 True False 3262054.2957630735 2733632.9241759083 1678213.7445327148 1.0 0.8380096332935026 0.5144653008113527 21.637349364732714 -6.96007136925571 0.4344294544199484 1.0122639337394281 0.32771248858817925 0.9997728296135069 0.003042208664957222 0.07967568058059282 0.021037429301169423 0.004238116132217168 0.026837718312451523 1.0962980225365264e-07 6.96007136925571 -0.6845514451512489 YISAAPGAEAK(ub)YR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YISAAPGAEAKYR 13 1 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72;H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;H0YDK8 A0A0C4DG68;H0YEH2 PUM2;PUM1 Pumilio homolog 2;Pumilio homolog 1 1 18399400.0 3782700.0 4631200.0 9985500.0 True False 3662620.2590452987 6480462.3113889545 7369997.991421172 1.0 1.7693514077482213 2.0122200692851084 21.804444699310917 -10.740594223358357 0.2343895993461783 8.067724353103043e-14 2.153423720941136 0.9992366989682813 0.011920535250440996 2.550025585775018 0.12173734734768762 1.5545598974224442 0.12082886576982597 1.8172127557501997e-11 10.740594223358357 2.1534237209410554 YISAAPGAEAK(ub)YR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YISAAPGAEAKYR 13 1 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72;H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;H0YDK8 A0A0C4DG68;H0YEH2 PUM2;PUM1 Pumilio homolog 2;Pumilio homolog 1 1 55401600.0 8389500.0 9951100.0 37061000.0 True False 12727484.854605574 8175248.456700823 29735877.105586644 1.0 0.6423302443563721 2.336351403696733 23.60144401304262 -6.851553374439692 1.2276358961905522 0.8088587125023823 2.4061029022226657 0.9425265708640748 0.17477682522673843 0.15575750106937564 0.4509489382481034 0.11135951588098873 0.2579510873454143 1.4074942378316773e-07 6.851553374439692 1.5972441897202834 up YISAAPGAEAK(ub)YR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YISAAPGAEAKYR 13 1 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72;H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;H0YDK8 A0A0C4DG68;H0YEH2 PUM2;PUM1 Pumilio homolog 2;Pumilio homolog 1 1 9096600.0 2488200.0 3489600.0 3118800.0 True False 3408154.7810766795 3335417.9334359556 2382203.673702233 1.0 0.9786579975637887 0.6989716801974776 21.700559426255605 -6.922162990083375 0.8085278489400867 1.0057033356156027 0.6515476398917167 0.9947608412867942 0.009927395417376805 0.09691581313858835 0.09914333128818645 0.008652919535385788 0.026480496677987124 1.1962914806068356e-07 6.922162990083375 -0.35415569572388594 YISAAPGAEAK(ub)YR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YISAAPGAEAKYR 13 1 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72;H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;H0YDK8 A0A0C4DG68;H0YEH2 PUM2;PUM1 Pumilio homolog 2;Pumilio homolog 1 1 19908300.0 3782700.0 8220800.0 7904800.0 True False 3145482.652023406 8176512.918698965 9557657.132334327 1.0 2.599446197371087 3.0385343648886884 21.584849974745193 -9.959297834212135 0.31986594091473114 1.0708111523440366e-23 3.166259225405231 0.9988292792783248 0.029973611915358998 1.3446919992115882 0.14206990118949797 1.4013664048302097 0.1442268144302875 1.098252412113239e-10 9.959297834212135 3.166259225405231 YISAAPGAEAK(ub)YR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YISAAPGAEAKYR 13 1 A0A0C4DG68;A0A0A0MR59;Q8TB72-2;Q8TB72-4;Q8TB72-3;Q8TB72;H0YEH2;Q14671;E9PR38;Q5T1Z4;Q5T1Z8;Q14671-4;Q14671-2;Q14671-3;H0YDK8 A0A0C4DG68;H0YEH2 PUM2;PUM1 Pumilio homolog 2;Pumilio homolog 1 1 41885500.0 8389500.0 10606000.0 22890000.0 True False 10860373.131768541 10015766.776576716 18724254.871233746 1.0 0.9222304477991461 1.7240894621255636 23.37257033513507 -6.883091825892817 1.0624397992889685 0.9495134455659165 1.7843884600747433 0.9760936068252734 0.05582723809311994 0.12492506198570219 0.2560534677934653 0.04035934725173993 0.09841002665451291 1.3089051428520466e-07 6.883091825892817 0.8348750145088267 YISGSIHYSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YISGSIHYSR 10 0 E7EQ29;P16278-2;P16278-3;P16278;F8WF40;C9JF15;C9JWX1 E7EQ29 GLB1 Beta-galactosidase 0 22397100.0 5637600.0 9269700.0 7489800.0 False True 7390948.194596063 7886696.893007589 6714827.343234738 1.0 1.0670751147699824 0.9085204180086562 22.81732803083895 -6.79182055702313 1.4895244650609183 1.0374000429862689 0.9067598424456198 0.8070203098792786 0.028547451648527896 0.23265387673323748 1.0197653517380527 0.015085411481345316 0.03526515322634229 1.6150257197124325e-07 6.79182055702313 -0.13064020054064907 YISGSIHYSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YISGSIHYSR 10 0 E7EQ29;P16278-2;P16278-3;P16278;F8WF40;C9JF15;C9JWX1 E7EQ29 GLB1 Beta-galactosidase 0 14144300.0 5410400.0 2255100.0 6478800.0 False True 5238649.813503226 3155573.190191144 4781807.92016619 1.0 0.6023638346768835 0.9127939622611396 22.320763595139546 -9.828102709957733 6.152568092430833 1.0000000149414439 0.7575788984688547 0.4484629340322359 0.12673256889531118 2.5953657081312935e-08 5.0522697807825185e-09 0.12270828950213775 0.040902760729386534 1.4855842624110134e-10 9.828102709957733 -0.24242111647258913 YISGSIHYSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YISGSIHYSR 10 0 E7EQ29;P16278-2;P16278-3;P16278;F8WF40;C9JF15;C9JWX1 E7EQ29 GLB1 Beta-galactosidase 0 18884500.0 5188500.0 5297900.0 8398100.0 False True 7871333.830159257 4352448.352318373 6738211.853982006 1.0 0.5529492772421661 0.8560444772605553 22.90817669642997 -9.94662127345271 5.497185642761762 1.0000004785680079 0.7044968772506787 0.558961144829929 0.12373809725771186 7.256692834397833e-07 1.3932449273464914e-07 0.11980909029876466 0.03993629916386102 1.1307815830291846e-10 9.94662127345271 -0.2955036013173292 YISGSIHYSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YISGSIHYSR 10 0 E7EQ29;P16278-2;P16278-3;P16278;F8WF40;C9JF15;C9JWX1 E7EQ29 GLB1 Beta-galactosidase 0 15415000.0 5637600.0 3247900.0 6529500.0 False True 7721973.070411506 3104397.038630973 4987366.579273677 1.0 0.402021220525383 0.645866870267122 22.880538092361842 -10.302668843801385 5.717732282689833 1.000049034882419 0.5239440453962616 0.8355772547512181 0.09954956964412813 6.223210388557618e-05 7.589839117464628e-06 0.09639834386314043 0.032129485446150026 4.981167618710703e-11 10.302668843801385 -0.4761049894861573 YISGSIHYSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YISGSIHYSR 10 0 E7EQ29;P16278-2;P16278-3;P16278;F8WF40;C9JF15;C9JWX1 E7EQ29 GLB1 Beta-galactosidase 0 12197800.0 5410400.0 3609300.0 3178100.0 False True 4498987.321359719 3589855.984510045 3842626.0161258685 1.0 0.7979253392128011 0.8541091009264102 22.101168870573822 -10.188985392872102 5.295021557007919 1.0000088341839477 0.8260172200695536 0.9274618553374475 0.02293692467159228 2.3921668607894857e-06 3.6643771231129303e-07 0.02220970925970641 0.00740286060549794 6.471643822096422e-11 10.188985392872102 -0.17399161411439412 YISGSIHYSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YISGSIHYSR 10 0 E7EQ29;P16278-2;P16278-3;P16278;F8WF40;C9JF15;C9JWX1 E7EQ29 GLB1 Beta-galactosidase 0 29101500.0 5188500.0 12766000.0 11147000.0 False True 6716615.530625322 12055560.877784122 9118360.377878655 1.0 1.7948862522821432 1.357582600388879 22.67930301852242 -10.09440114859971 4.289327037367625 0.9999279090789515 1.576234426397638 0.698350543460081 0.17852846855236937 31050588.266445935 3.6588493723543785 23060.170858351714 0.06111504332689251 8.046348736800548e-11 10.09440114859971 0.5763065173186865 YISPDQLADLYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YISPDQLADLYK 12 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 208081000.0 23896000.0 94310000.0 89875000.0 False True 31327887.40919319 80239315.61750074 80575597.14187604 1.0 2.5612743869206596 2.5720086416753105 24.90094414930375 -10.773972831319194 0.8660587017639625 4.783305167428177e-16 2.569480752343304 0.9999932238328878 0.0019224768328352608 2.571486093766961 0.47736991386165395 5.376680104693454 0.0014916915378879868 1.6827793294226057e-11 10.773972831319194 2.5694807523433036 YISPDQLADLYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YISPDQLADLYK 12 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 231012000.0 77495000.0 38207000.0 115310000.0 False True 75034963.64361833 53463254.34687287 85106851.77415004 1.0 0.7125112314413693 1.1342292664839362 26.161059661438287 -6.723175572997764 1.7478659404793517 0.8256878075452864 1.1336919928010174 0.5274149814037585 0.12093214581043245 0.34921173221832535 2.086626269844896 0.05490043566844222 0.13730972082298878 1.891578752163147e-07 6.723175572997764 0.30800418525573103 YISPDQLADLYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YISPDQLADLYK 12 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 589332000.0 26211000.0 544670000.0 18451000.0 False True 39764003.28077562 447469382.9738658 14804151.762639403 1.0 11.25312710126951 0.37230033550964536 25.244959673188816 -6.6595728097867175 1.974406053072447 7.602179790735885 0.4176019807480954 0.23381915583883695 4.366003277494427 0.48542028047412916 3.637232199714505 1.786823320892832 4.839686613336664 2.1899146565012754e-07 6.6595728097867175 -7.18457780998779 YISPDQLADLYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YISPDQLADLYK 12 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 231542000.0 23896000.0 107680000.0 99966000.0 False True 32730996.965118732 102922341.54985781 76356089.66439566 1.0 3.1444914940886664 2.3328372718303685 24.964154210826642 -10.350586006098336 5.850192109358453 0.9997239300543107 2.738664382959521 0.859516290833853 0.3313564486847389 0.001193298944824188 0.0001324641966165987 0.3208809527555502 0.1069448339512003 4.460812755210507e-11 10.350586006098336 1.7389404529052102 YISPDQLADLYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YISPDQLADLYK 12 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 117028000.0 77495000.0 21884000.0 17649000.0 False True 64440526.110596545 21766106.548366103 21339324.300243977 1.0 0.3377704662281909 0.33114758038474423 25.941464936872563 YISPDQLADLYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YISPDQLADLYK 12 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 81401000.0 26211000.0 24934000.0 30256000.0 False True 33930656.19605287 23546400.981252473 24749718.452776223 1.0 0.6939565461157102 0.7294205661620933 25.016085995281266 -10.033661521468654 7.305868533572742 1.000000025114263 0.71168855631075 0.9887794810547731 0.01447812555691223 5.9125804425484485e-09 8.005792812773504e-10 0.014018386044893987 0.0046727949305183925 9.254191420673789e-11 10.033661521468654 -0.2883114688035129 YISPDQLADLYK(ub)SFIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YISPDQLADLYKSFIK 16 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 94134500.0 3486100.0 9871400.0 80777000.0 True False 5288668.568048213 8109771.54439977 64811390.54418312 1.0 1.5334240442661522 12.254765015101299 22.334473136267896 -6.917242218266628 0.8449324258421643 0.7391219691034578 13.878548473361109 0.9933798660763695 0.42182406229700586 0.09982160595232407 0.11422460810708786 0.3582340391606104 1.0463455383995222 1.2099231371186258e-07 6.917242218266628 13.139426504257651 up YISPDQLADLYK(ub)SFIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YISPDQLADLYKSFIK 16 1 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 1 162453500.0 3486100.0 6224400.0 152743000.0 True False 4512825.171304405 5878006.668312652 124945341.2755289 1.0 1.3025114967202795 27.686723179531946 22.105599458360345 -6.909405109568885 0.8997839926809695 0.1676444167725226 31.053319915285094 0.990694955003884 1.2067043810587212 0.1048125162458119 0.14091367330500387 0.9850484139757242 2.7080752183025347 1.2319551302643436e-07 6.909405109568885 30.885675498512573 up YITDWQNVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YITDWQNVFR 10 0 O75340;A0A024QZ42;O75340-2 O75340 PDCD6 Programmed cell death protein 6 0 22036800.0 5907600.0 6331100.0 9798100.0 False True 7744920.8092797855 5386524.558434511 8784286.60201185 1.0 0.6954912375579749 1.1341996668948144 22.884819057061623 -6.719983671962716 1.7590720518076868 0.8147443385365832 1.1335304555217212 0.5126182136849933 0.12813806188307988 0.355328369055798 2.1487232155312435 0.05783583804438446 0.14520893851734976 1.9055323583358808e-07 6.719983671962716 0.3187861169851379 YITDWQNVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YITDWQNVFR 10 0 O75340;A0A024QZ42;O75340-2 O75340 PDCD6 Programmed cell death protein 6 0 21869700.0 9117500.0 2492200.0 10260000.0 False True 8828069.953167167 3487348.456651312 7572598.206597685 1.0 0.39502954498000864 0.8577863844272023 23.073666630827464 -9.909172650843688 6.598098369343289 1.0000000237143643 0.6264079647036274 0.46495938144000903 0.18891968860481573 6.601716495080303e-08 1.0740823572237891e-08 0.18292071283716785 0.060973567311422845 1.232614718142286e-10 9.909172650843688 -0.3735920590107369 YITDWQNVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YITDWQNVFR 10 0 O75340;A0A024QZ42;O75340-2 O75340 PDCD6 Programmed cell death protein 6 0 23146500.0 5907600.0 8441900.0 8797000.0 False True 8091799.366887155 8068908.944369852 6719329.779902063 1.0 0.9971711579242839 0.8303875906017343 22.948029118584515 -6.910581923965849 0.8917630413324565 1.005069384869906 0.8085631879095055 0.9911393172452064 0.007464385622996728 0.10403442746975852 0.13668937525385075 0.006128831927215786 0.01698733450139138 1.2286214013820418e-07 6.910581923965849 -0.1965061969604004 YITDWQNVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YITDWQNVFR 10 0 O75340;A0A024QZ42;O75340-2 O75340 PDCD6 Programmed cell death protein 6 0 18165000.0 9117500.0 4611000.0 4436500.0 False True 7581605.223735253 4586159.627788154 5364151.637941671 1.0 0.6049061501422619 0.7075218874689571 22.85407190626174 -10.028126671898134 7.092823857999777 1.0000000439502994 0.656214018805612 0.9373643866324544 0.0418926993383127 2.9142102244121413e-08 3.919971125098448e-09 0.04056243715606484 0.013520810572079883 9.372885854440685e-11 10.028126671898134 -0.34378602514468737 YITDWQNVFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YITDWQNVFR 10 0 O75340;A0A024QZ42;O75340-2 O75340 PDCD6 Programmed cell death protein 6 0 14391100.0 3354900.0 6906500.0 4129700.0 False True 4342984.184965762 6522147.203698568 3378136.974300305 1.0 1.5017662800330887 0.7778377333250492 22.05025526853251 -6.720293303763288 1.7585073638189814 1.3051766394001691 0.7789663059060641 0.5138003140999725 0.2111373998908254 0.3547423897058042 2.14408130270387 0.09533363431307998 0.2392181755662015 1.9041742864201007e-07 6.720293303763288 -0.5262103334941051 YIVAYHAAGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIVAYHAAGK 10 0 Q96PZ0;Q96PZ0-2;E7EUH7;H0Y863 Q96PZ0 PUS7 Pseudouridylate synthase 7 homolog 0 1791080.0 667400.0 482030.0 641650.0 False True 874967.8631107938 410113.00293822313 575258.2131414157 1.0 0.46871778979417456 0.6574621050608496 19.738870503287917 -10.07408038839426 4.968476783397722 1.00001007861535 0.5630899474268158 0.8772185498267923 0.07705454405292624 106997947.69406107 4.414363686941746 13421.292549125377 0.02637781995842864 8.431786700039913e-11 10.07408038839426 -0.43692013118853423 YIVPMLTVDGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIVPMLTVDGK 11 0 P14550 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 6606200.0 1600600.0 2286200.0 2719400.0 False True 2098402.100232451 1945107.8715378004 2438022.5743267597 1.0 0.9269471619964211 1.161847185559282 21.000859725993877 -6.823160156015804 1.3581679668133158 0.9607461235768043 1.1673304544593701 0.8914955140464411 0.032332203239523676 0.1894049192592877 0.6856365736503902 0.018703038025300475 0.043075012253957386 1.502587750332546e-07 6.823160156015804 0.20658433088256578 YIVPMLTVDGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIVPMLTVDGK 11 0 P14550 P14550 AKR1A1 Alcohol dehydrogenase [NADP(+)] 0 7601100.0 1600600.0 2985400.0 3015100.0 False True 2192385.0745885954 2853495.15660239 2302995.477933692 1.0 1.3015483409719222 1.0504520873760521 21.064069787516768 -10.18625585850432 3.930734949377262 0.9998907517917351 1.1760002141110766 0.3957942671406436 0.10250961646322078 13737649.476857658 11866767.766612627 11374.515017615377 0.035091765957017386 6.512446093914189e-11 10.18625585850432 0.17610946231934144 YIVQVSPLGIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIVQVSPLGIR 11 0 Q10570 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 0 10743200.0 4357900.0 4621000.0 1764300.0 False True 5713249.101963634 3931564.8125169165 1581747.1603606322 1.0 0.6881486772851624 0.27685597671856954 22.445880003207687 -7.192550547806277 0.35844324788767906 1.0425797220808153 1.5995371100738132e-14 0.9998225890480402 0.003944603521718741 0.0879462076592984 0.020748310715920967 0.008653648037126397 0.04172718486827524 6.418735091011744e-08 7.192550547806277 -1.0425797220807993 down YIVQVSPLGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIVQVSPLGIR 11 0 Q10570 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 0 9821300.0 3871900.0 2107300.0 3842100.0 False True 3748988.6538709025 2948755.8794243257 2835738.749470659 1.0 0.786547026857411 0.7564009953838363 21.83807002871146 -13.999999999999828 0.2757324603666302 2.699407204339418 0.746937483215069 0.9995957747764574 0.0021799936052200016 15.172086980441602 0.16628406433839737 14.50272695861688 0.012171687515917084 1.0000000000003968e-14 13.999999999999828 -1.9524697211243491 YIVQVSPLGIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIVQVSPLGIR 11 0 Q10570 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 0 14111900.0 4357900.0 4965800.0 4788200.0 False True 5969133.397819337 4746394.536295364 3657325.7760744635 1.0 0.7951563853522409 0.612706323067025 22.50909006473058 -6.972493645363319 0.18937867153540114 1.1246629899845646 0.2782186848792655 0.9999958620838779 0.0003217566814219051 0.0755015425124706 0.00603713727371717 0.006475544655756544 0.019923421330117055 1.06538445235651e-07 6.972493645363319 -0.8464443051052991 YIVQVSPLGIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIVQVSPLGIR 11 0 Q10570 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 0 8618300.0 3871900.0 2714700.0 2031700.0 False True 3219656.404253417 2700075.3722742405 2456519.0764805763 1.0 0.8386222109623966 0.7629755377733236 21.618475304145736 -13.999999999955184 0.10110090343610488 1.7944627830806337 0.6045710631288933 0.9997881879016146 0.0014386600904668966 12.072173994061055 0.09491315751594645 1.9955375314327288 0.14118973885144517 1.000000000103192e-14 13.999999999955184 -1.1898917199517403 YIYIMGIQER ddPTM_RPMI8226_Bortezomib_1h_R1 1 YIYIMGIQER 10 0 A0A1W2PQT3;A0A1W2PPH1;A0A1W2PQY8;P23368;A0A1W2PQF8;A0A1W2PQH3;P23368-2;A0A1W2PQ37;A0A1W2PR68;A0A1W2PRS2;A0A1W2PRY9;A0A1W2PQH4;A0A1W2PPY2 A0A1W2PQT3 ME2 NAD-dependent malic enzyme, mitochondrial 0 8278700.0 2993900.0 3232900.0 2051900.0 False True 3925031.8929688386 2750563.9217455015 1839589.0712146363 1.0 0.7007749227905035 0.46868130536977554 21.904272946039534 -7.384129384051854 0.16245304164974397 1.2584539255802447 3.5382626301451177e-13 0.9999871736338081 0.0007788822527747789 0.11940062412377456 0.011665664773761653 0.028455440831032724 0.05540959449658287 4.129244661197847e-08 7.384129384051854 -1.258453925579891 down YIYIMGIQER ddPTM_RPMI8226_Bortezomib_2h_R1 1 YIYIMGIQER 10 0 A0A1W2PQT3;A0A1W2PPH1;A0A1W2PQY8;P23368;A0A1W2PQF8;A0A1W2PQH3;P23368-2;A0A1W2PQ37;A0A1W2PR68;A0A1W2PRS2;A0A1W2PRY9;A0A1W2PQH4;A0A1W2PPY2 A0A1W2PQT3 ME2 NAD-dependent malic enzyme, mitochondrial 0 8010000.0 3166200.0 1336300.0 3507500.0 False True 3065690.714090253 1869891.5587124384 2588780.5272554955 1.0 0.6099413584410881 0.8444363012084599 21.5477807256309 -10.299718410326403 5.73323020339867 1.0000263624996881 0.727188829824772 0.6434509009702964 0.09573215950720824 3.226173953283413e-05 3.940447494300952e-06 0.09270121137650561 0.030897421622323045 5.015123008760064e-11 10.299718410326403 -0.27283753267491617 YIYIMGIQER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YIYIMGIQER 10 0 A0A1W2PQT3;A0A1W2PPH1;A0A1W2PQY8;P23368;A0A1W2PQF8;A0A1W2PQH3;P23368-2;A0A1W2PQ37;A0A1W2PR68;A0A1W2PRS2;A0A1W2PRY9;A0A1W2PQH4;A0A1W2PPY2 A0A1W2PQT3 ME2 NAD-dependent malic enzyme, mitochondrial 0 13174200.0 2993900.0 4446500.0 5733800.0 False True 4100825.7371053244 4250038.927390821 4379594.53131777 1.0 1.0363861329037656 1.0679786979705266 21.967483007562425 -6.972777929292603 0.17985431216132816 0.9755300679977271 1.1296889571408286 0.9999966847859677 5.024164951922657e-05 0.07541118460883296 0.00567107293042557 0.001218157761506514 0.003546950009849679 1.0646872927459651e-07 6.972777929292603 0.1541588891431015 YIYIMGIQER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YIYIMGIQER 10 0 A0A1W2PQT3;A0A1W2PPH1;A0A1W2PQY8;P23368;A0A1W2PQF8;A0A1W2PQH3;P23368-2;A0A1W2PQ37;A0A1W2PR68;A0A1W2PRS2;A0A1W2PRY9;A0A1W2PQH4;A0A1W2PPY2 A0A1W2PQT3 ME2 NAD-dependent malic enzyme, mitochondrial 0 6963300.0 3166200.0 1961100.0 1836000.0 False True 2632835.586442617 1950535.1650521266 2219899.1112951417 1.0 0.7408495901134535 0.8431590345884764 21.328186001065177 -10.139449779995052 5.449692623706069 1.0000042493266605 0.792004312415219 0.8464094287697672 0.04176765580542166 2.1564848379253597e-06 3.4048758296580207e-07 0.040442184928918115 0.01348045294534985 7.253543501976267e-11 10.139449779995052 -0.20799993691144159 YK(ub)ADLATDQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKADLATDQK 10 1 Q13895 Q13895 BYSL Bystin 1 1273770.0 0.0 506500.0 767270.0 True False 0.0 484121.15522848297 586056.6284216726 0.0 YK(ub)ADLATDQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKADLATDQK 10 1 Q13895 Q13895 BYSL Bystin 1 14729300.0 0.0 1574300.0 13155000.0 True False 0.0 1486688.8210790786 10760924.981698547 0.0 YK(ub)AEDEVQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKAEDEVQR 9 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 1 35895400.0 10526000.0 14951700.0 10417700.0 True False 13799687.933928985 12720964.641270116 9339776.33763473 1.0 0.9218298777607401 0.6768106918324747 23.71813230648573 -6.9504609817975815 0.5537577517152753 1.0033154861432896 0.5837399601450611 0.9992369757255006 0.003803051655448177 0.08330112852430177 0.03520009430936791 0.004108096137348548 0.020341256233222825 1.1208281198728244e-07 6.9504609817975815 -0.41957552599822845 YK(ub)AEDEVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKAEDEVQR 9 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 1 45390100.0 14323700.0 13329900.0 17736500.0 True False 13869001.983896978 18652598.584510185 13090778.566405468 1.0 1.34491282113647 0.9438875689544864 23.725360638990093 -6.6790460552019475 1.9048633039994516 1.2184080199381926 0.9454086861869077 0.31998604367293526 0.14621124473644775 0.4406218099362751 3.090174250482325 0.06160339357863273 0.162698276474254 2.0938903953309872e-07 6.6790460552019475 -0.27299933375128493 YK(ub)AEDEVQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YKAEDEVQR 9 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 1 141039710.0 10944710.0 64634000.0 65461000.0 True False 16603925.235478887 53099557.71225304 52522604.65742441 1.0 3.1980123349863754 3.163264343373175 23.98502100508124 -10.24266138698962 5.247444087865361 0.9997685316499015 3.1806383391802098 0.999809598324251 0.014185808174659868 3.841828064379526e-05 5.544651625284883e-06 0.013736697859741782 0.004578449900860417 5.719243838956869e-11 10.24266138698962 2.1808698075303083 YK(ub)AEDEVQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKAEDEVQR 9 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 1 32199100.0 10526000.0 10022100.0 11651000.0 True False 14417746.654454269 9579290.483347233 8899273.759877114 1.0 0.6644096829366727 0.6172444261342144 23.781342368008623 -13.999999999999998 0.27642930251389364 3.6819818105876743 0.6025388118452377 0.999597304830357 0.003419599976155514 15.208409472038655 0.16650310593786036 23.01034220767192 0.018979239858473447 1.0000000000000041e-14 13.999999999999998 -3.0794429987424365 YK(ub)AEDEVQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKAEDEVQR 9 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 1 38952600.0 14323700.0 16885200.0 7743700.0 True False 11910791.197501156 16794236.076150198 9362871.867176576 1.0 1.41000172009342 0.786083116723671 23.50576591442437 -6.729432304402875 1.7251068550085722 1.2468935940258772 0.7864806172644759 0.5566801517944379 0.1723634010500242 0.33732232501237114 1.9663760169294964 0.07918340232818509 0.19662914799025824 1.8645227878549337e-07 6.729432304402875 -0.46041297676140125 YK(ub)AEDEVQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKAEDEVQR 9 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 1 124551710.0 10944710.0 60355000.0 53252000.0 True False 14168142.847487744 56996191.19369098 43560682.41166182 1.0 4.022841370758581 3.0745513283264136 23.75614732717369 -10.150111443771625 10.1561119158006 0.9999999940480039 3.5486963495424972 0.9059396249935908 0.3871377886868364 5.1728317485487254e-08 5.499761198239466e-09 0.37484454927510436 0.12494818402264028 7.077641425955617e-11 10.150111443771625 2.5486963554944935 YK(ub)APFHQLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKAPFHQLR 9 1 O60264;A0A0A0MRP6;B7ZLQ5;P28370-2;P28370 O60264 SMARCA5;SMARCA1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Probable global transcription activator SNF2L1 1 11112100.0 4710200.0 4982300.0 1419600.0 True False 6175117.813641685 4238960.260853286 1272713.409764752 1.0 0.686458200277384 0.2061035025037341 22.558035231128404 -7.275125297116094 0.43894884638685017 1.021540123366158 2.1093105620102206e-23 0.999286962577723 0.008717997292118725 0.0980450498376371 0.03576054855175646 0.011722195980921446 0.05169957166744179 5.307313023007313e-08 7.275125297116094 -1.021540123366158 down YK(ub)APFHQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKAPFHQLR 9 1 O60264;A0A0A0MRP6;B7ZLQ5;P28370-2;P28370 O60264 SMARCA5;SMARCA1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5;Probable global transcription activator SNF2L1 1 8720100.0 4710200.0 2873400.0 1136500.0 True False 6451688.228368855 2746443.686936864 868082.1069522217 1.0 0.42569380133100954 0.13455115563941225 22.621245292651295 -8.873334038463119 0.29565087080114794 1.2341861990152927 5.133133669194894e-25 0.9986820009059921 0.013053797592848757 0.37801716582553696 0.09742062004275931 0.19409844207237284 0.09704508397034405 1.338646668612941e-09 8.873334038463119 -1.2341861990152927 YK(ub)ASQDPFPAAIILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKASQDPFPAAIILK 15 1 Q96KB5;Q96KB5-2;E5RFX4 Q96KB5 PBK Lymphokine-activated killer T-cell-originated protein kinase 1 12702600.0 4606900.0 4356900.0 3738800.0 True False 4460656.48118957 6096632.890933343 2759496.118404232 1.0 1.3667568701249753 0.6186300447122366 22.08882461858635 -6.773385667954251 1.5613353571168247 1.2094488730551904 0.6138561983235364 0.7434039115834989 0.15472205763900568 0.2609857985335229 1.256021020994643 0.07808606823724824 0.18531809625607443 1.6850559749834988e-07 6.773385667954251 -0.595592674731654 YK(ub)ASQDPFPAAIILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKASQDPFPAAIILK 15 1 Q96KB5;Q96KB5-2;E5RFX4 Q96KB5 PBK Lymphokine-activated killer T-cell-originated protein kinase 1 11868700.0 4606900.0 4575100.0 2686700.0 True False 3830841.470274309 4550453.02821375 3248476.5481027593 1.0 1.187846864330805 0.847979895098648 21.869229894020627 -6.756635450165178 1.6248668940740152 1.1095641385245536 0.8469285372481253 0.6772130103489038 0.07897582658148933 0.28859405920683234 1.500863376316953 0.03836206748894893 0.09250881081618198 1.7513161388579482e-07 6.756635450165178 -0.26263560127642827 YK(ub)ASQDPFPAAIILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKASQDPFPAAIILK 15 1 Q96KB5;Q96KB5-2;E5RFX4 Q96KB5 PBK Lymphokine-activated killer T-cell-originated protein kinase 1 14491800.0 3987200.0 6689600.0 3815000.0 True False 5161508.999462128 6317317.879368986 3120709.1452056286 1.0 1.2239284829353787 0.6046117803012322 22.299361477564972 -6.808901087933061 1.419267208476761 1.1221965277910255 0.594058404736124 0.8569163101058571 0.09685242180032853 0.20829847135570687 0.827179635140739 0.053663212018517495 0.124190110809435 1.5527406117221376e-07 6.808901087933061 -0.5281381230549015 YK(ub)AVLQEYGHEER ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKAVLQEYGHEER 13 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 11109400.0 4399700.0 1602100.0 5107600.0 True False 5768049.306755406 1363072.9249368873 4579114.547558782 1.0 0.23631436772575573 0.7938757635438083 22.459652066480487 -10.117843210076275 6.991365162511777 1.0000003297435818 0.5150950656384277 0.5021106233196051 0.22762348667136553 1.1698232737967652e-06 1.4749968109773426e-07 0.22039564433556147 0.07346516442365536 7.62354187090817e-11 10.117843210076275 -0.4849052641051541 YK(ub)AVLQEYGHEER ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKAVLQEYGHEER 13 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 23029600.0 4935200.0 6249300.0 11845100.0 True False 4778534.777391904 8744678.079668988 8742512.964616988 1.0 1.8299915114234622 1.8295384195966027 22.188136887647154 -10.257194157961074 4.085832473397082 0.9992344596360644 1.82976496557109 0.9999997761550604 0.00018497416699139258 23452.284899233055 14719.698969315295 149.63675400471638 6.332155053489554e-05 5.5310278091369136e-11 10.257194157961074 0.8305305059350255 YK(ub)AVLQEYGHEER ddPTM_RPMI8226_Bortezomib_8h_R1 1 YKAVLQEYGHEER 13 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 35733700.0 6294600.0 11515700.0 17923400.0 True False 9549368.39690092 9460633.362425238 14380832.133894712 1.0 0.9907077587974845 1.5059458946585156 23.18697388458855 -6.902796654236637 0.943442375312857 0.9801904583822815 1.5632035926555845 0.9879061909756989 0.026473004775539287 0.10937565075632266 0.16604807274562286 0.020929699647300442 0.055259282991257125 1.2508445647244488e-07 6.902796654236637 0.583013134273303 YK(ub)AVLQEYGHEER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKAVLQEYGHEER 13 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 15894800.0 4399700.0 4328900.0 7166200.0 True False 6026387.98742186 4137634.884242014 5473691.152521778 1.0 0.6865862093310274 0.9082872134927823 22.52286212800338 -10.059519332713965 5.634276425350031 1.000001017730408 0.7974367126729374 0.5267562973496549 0.09050905594336407 1.1570412073321902e-06 1.9306742172641695e-07 0.08763545664949882 0.029211672195770436 8.719280863534519e-11 10.059519332713965 -0.20256430505747058 YK(ub)AVLQEYGHEER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKAVLQEYGHEER 13 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 22761400.0 4935200.0 11233600.0 6592600.0 True False 4103837.466430304 11173082.367104992 7971082.179261635 1.0 2.7225937816742594 1.9423484103514528 21.96854216308143 -10.100092776045836 4.699974830524682 0.9999335009515785 2.332471096034488 0.7954419545451223 0.31853383913410727 83805728.4414119 11.909785668449603 71235.61714504617 0.11657144879309687 7.941585646850664e-11 10.100092776045836 1.3325375950829095 YK(ub)AVLQEYGHEER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKAVLQEYGHEER 13 1 Q13049 Q13049 TRIM32 E3 ubiquitin-protein ligase TRIM32 1 29323600.0 6294600.0 15433600.0 7595400.0 True False 8148483.785115953 14574706.59277525 6213115.135385264 1.0 1.788640313600115 0.7624872674759641 22.958100206681 -6.701401436339059 1.8259075648752336 1.4890387438704944 0.7654610433399386 0.424230566279336 0.3328098915858731 0.3926062950885591 2.5457103175997857 0.14535998193907643 0.3731772051242856 1.9888341275057732e-07 6.701401436339059 -0.7235777005305558 YK(ub)CSVCPDYDLCSVCEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKCSVCPDYDLCSVCEGK 18 1 Q13501;Q13501-2;E7EMC7;E9PFW8;C9JRJ8;E3W990 Q13501 SQSTM1 Sequestosome-1 1 0.0 0.0 0.0 0.0 True False 0.0 0.0 0.0 0.0 YK(ub)DAIHFYNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKDAIHFYNK 10 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 2924520.0 1099100.0 950430.0 874990.0 True False 1064209.672116923 1329941.6554269723 645803.869862663 1.0 1.2496988988847058 0.6068389404674661 20.021350990015293 -6.801395219074565 1.4503932833391358 1.1375267347080118 0.5976745230562905 0.8361605598668941 0.10710879505663336 0.21877323651520966 0.908466632602195 0.058094427986386345 0.13498189263471788 1.5798097177084018e-07 6.801395219074565 -0.5398522116517213 YK(ub)DAIHFYNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKDAIHFYNK 10 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 1 3669200.0 1099100.0 2014100.0 556000.0 True False 913950.3483857886 2003249.6435324533 672257.0293464591 1.0 2.1918582853768545 0.7355509306756037 19.80175626544957 -6.689131034234732 1.8691941324338368 1.747802501181919 0.7405834992883179 0.36655019844581394 0.5041573068048312 0.4185073685594316 2.834222647972702 0.2158115481375544 0.5626687141876107 2.0458272817530712e-07 6.689131034234732 -1.007219001893601 YK(ub)DDADSPTEDGDKPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKDDADSPTEDGDKPR 16 2 O60291-4;O60291;O60291-3;O60291-2;B4DR12;K7EIM7;K7EPJ5;K7ERA1;K7EJN3 O60291-4 MGRN1 E3 ubiquitin-protein ligase MGRN1 1 1957740.0 521850.0 873650.0 562240.0 True False 714792.0474659855 835049.2542257927 429450.4916962751 1.0 1.168240829184001 0.6008047980090477 19.447164057969534 -6.827272265730583 1.3400319547433293 1.0900809442423298 0.5863666934198349 0.9003104475359949 0.07513419483204282 0.18420298596434376 0.6478506286027342 0.04403472530486925 0.10135588739878704 1.488427667507161e-07 6.827272265730583 -0.5037142508224949 YK(ub)DLEQQDCEIAQEIQEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKDLEQQDCEIAQEIQEK 18 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 8663500.0 2222600.0 2894600.0 3546300.0 True False 2913850.1236890163 2462736.9630624293 3179362.8945116526 1.0 0.845183128343106 1.0911209429284199 21.474495242412466 -6.7365583966415965 1.6994041672149849 0.9075193541440587 1.0911568476198326 0.5893659143050705 0.06505473076857565 0.32406984067874073 1.8362942975061156 0.030301696254190123 0.07463731466728392 1.834178520955578e-07 6.7365583966415965 0.18363749347577385 YK(ub)DLEQQDCEIAQEIQEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKDLEQQDCEIAQEIQEK 18 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 8425900.0 2222600.0 2414200.0 3789100.0 True False 3044355.2835065634 2307532.6613081987 2894192.61896407 1.0 0.7579708826396654 0.9506750524959977 21.537705303935358 -9.92710277469953 5.616313354173713 1.0000001372980005 0.8543229677345184 0.4324539040198384 0.07867114790999909 1.3526463927147176e-07 2.5869062704822413e-08 0.07617308292921256 0.025391003806740652 1.1827616250329174e-10 9.92710277469953 -0.1456771695634821 YK(ub)DLEQQDCEIAQEIQEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKDLEQQDCEIAQEIQEK 18 1 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 7191000.0 1667900.0 2854900.0 2668200.0 True False 1386932.750498276 2839520.0870467178 3226108.283637094 1.0 2.0473379736880384 2.3260740526013732 20.40346640538168 -10.45754269344154 0.284090441358468 8.172584999411689e-12 2.4308660525639603 0.9990768372820749 0.017345228605117793 2.027891645755859 0.13770102050754113 1.5747374094454973 0.10699781093121377 3.487043029753768e-11 10.45754269344154 2.4308660525557877 YK(ub)DNPFSLGESFGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKDNPFSLGESFGSR 15 1 Q8N6H7;G5E9L0;A0A0D9SF70;E9PQP3;Q8N6H7-2;Q8N6H7-3;E9PMU9;H0YDN9 Q8N6H7 ARFGAP2 ADP-ribosylation factor GTPase-activating protein 2 1 3980800.0 1378100.0 1166900.0 1435800.0 True False 1806702.4455393862 992803.0685405751 1287237.189166125 1.0 0.5495111112467534 0.7124787993419822 20.78492749074921 -10.178886661484983 4.826624113666039 1.0000401630164375 0.630994955293038 0.8723834276464845 0.06653128007031019 17135728.54150897 36137610.71135321 4904.606694357733 0.022775427778547783 6.623893459382918e-11 10.178886661484983 -0.36904520772339955 YK(ub)DNPFSLGESFGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKDNPFSLGESFGSR 15 1 Q8N6H7;G5E9L0;A0A0D9SF70;E9PQP3;Q8N6H7-2;Q8N6H7-3;E9PMU9;H0YDN9 Q8N6H7 ARFGAP2 ADP-ribosylation factor GTPase-activating protein 2 1 7987200.0 3025100.0 1647600.0 3314500.0 True False 2929069.8563560247 2305495.2721204944 2446333.0171313905 1.0 0.7871083262550446 0.835191080138596 21.48201117026307 -10.749097528905894 6.903826290804538 1.0034988924659907 0.8111497031968216 0.9536353520286895 0.019629702073754543 0.0010734292791521795 3.901109483554278e-05 0.019299086989713044 0.0063354591018887135 1.781978546075233e-11 10.749097528905894 -0.1923491892691691 YK(ub)DNPFSLGESFGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKDNPFSLGESFGSR 15 1 Q8N6H7;G5E9L0;A0A0D9SF70;E9PQP3;Q8N6H7-2;Q8N6H7-3;E9PMU9;H0YDN9 Q8N6H7 ARFGAP2 ADP-ribosylation factor GTPase-activating protein 2 1 4648060.0 1378100.0 855360.0 2414600.0 True False 1887620.8117521827 817567.3669027343 1844321.2102479825 1.0 0.43312055144371286 0.9770612819933855 20.848137552272103 -10.815749060995525 10.371315580705682 1.0036204580082024 0.7050909167185493 0.2815746357708999 0.2220628733605686 0.018678532936497825 0.0003318315832366396 0.21603737483016636 0.07167048419470409 1.5284489538024883e-11 10.815749060995525 -0.29852954128965314 YK(ub)EALEQCR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKEALEQCR 9 1 X5CMH5;A0A0G2JLV0;A0A087WYD6;Q03519;A0A140T9S0;E7ENX8;Q03519-2 X5CMH5 TAP2 Antigen peptide transporter 2 1 22804320.0 1622900.0 3114800.0 18066620.0 True False 2127637.6161859552 2650083.981395307 16197259.46965631 1.0 1.2455523258448022 7.612790517725398 21.020821018165204 -6.9150400034817245 0.8606926909515168 0.8328695058111639 8.530971592098572 0.9926888619022516 0.2617368712096887 0.10117912443369054 0.12138203756914277 0.2197777337872367 0.6301305369122331 1.2160739811852442e-07 6.9150400034817245 7.698102086287408 up YK(ub)EALEQCR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKEALEQCR 9 1 X5CMH5;A0A0G2JLV0;A0A087WYD6;Q03519;A0A140T9S0;E7ENX8;Q03519-2 X5CMH5 TAP2 Antigen peptide transporter 2 1 23750530.0 1622900.0 932730.0 21194900.0 True False 2222929.9872234324 891518.9044743581 16189101.142667525 1.0 0.4010557730555952 7.282775991918956 21.084031079688096 -6.885709551611385 1.0474780652331495 0.5913150130149704 7.827110883638484 0.9780051823112734 0.4616070896643575 0.12269124262893637 0.2427607565501122 0.33753944436526734 0.8294541167597009 1.3010393990408822e-07 6.885709551611385 7.235795870623514 up YK(ub)EALLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKEALLGR 8 1 P52565;J3KTF8;J3QQX2;J3KRE2;J3KRY1;P52565-2;J3KS60 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 1 5153600.0 1639200.0 1832500.0 1681900.0 True False 2149007.0740353805 1559098.143029054 1507873.121924017 1.0 0.7254969803805241 0.7016603808067279 21.035238801116844 -13.999999999999998 0.3460256033023301 4.294195830558872 0.6981917988790489 0.9997470628172064 0.0021529250029581407 20.270406137464263 0.18908367741911467 48.98796422915886 0.007209998171693767 1.0000000000000041e-14 13.999999999999998 -3.596004031679823 YK(ub)EALLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKEALLGR 8 1 P52565;J3KTF8;J3QQX2;J3KRE2;J3KRY1;P52565-2;J3KS60 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 1 7812500.0 2292000.0 2077900.0 3442600.0 True False 2219241.714577371 2907616.3061053525 2540879.784213766 1.0 1.3101845945875592 1.1449315176096748 21.081635380360897 -10.193577391565524 3.954928445897901 0.9998606459094305 1.227558055981922 0.7165752577237349 0.06746428651617535 15798690.359591516 5.7842323605171115 21169.43398337316 0.02309481966698571 6.40357659240528e-11 10.193577391565524 0.22769741007249145 YK(ub)EALLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YKEALLGR 8 1 P52565;J3KTF8;J3QQX2;J3KRE2;J3KRY1;P52565-2;J3KS60 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 1 24184500.0 4267100.0 5335400.0 14582000.0 True False 6473502.666796291 4383256.184329537 11699861.308482366 1.0 0.6771073420286071 1.807346333306228 22.62611510266439 -6.830338732366727 1.3263277863982978 0.82750532617998 1.837985796825628 0.9065625161408775 0.14529887427314225 0.1803938482402645 0.620502908859676 0.08600957875645511 0.19793746959179556 1.4779551924264062e-07 6.830338732366727 1.010480470645648 YK(ub)EALLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKEALLGR 8 1 P52565;J3KTF8;J3QQX2;J3KRE2;J3KRY1;P52565-2;J3KS60 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 1 5176600.0 1639200.0 1793800.0 1743600.0 True False 2245256.5377143705 1714543.9846966474 1331797.5905691984 1.0 0.7636294365017288 0.5931605445518238 21.098448862639735 -7.247783086032416 0.10634765932371092 1.398960444972871 3.794467835879443e-09 0.9999989544082135 0.00017047888363673272 0.10020811675063719 0.005297882530998262 0.02561544273155756 0.042317455930677206 5.652192103313202e-08 7.247783086032416 -1.3989604411784031 YK(ub)EALLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKEALLGR 8 1 P52565;J3KTF8;J3QQX2;J3KRE2;J3KRY1;P52565-2;J3KS60 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 1 8044200.0 2292000.0 3468200.0 2284000.0 True False 1905899.5528161481 3449516.118216203 2761573.8399771834 1.0 1.8099149627897306 1.448960852053664 20.862040655795173 -10.039944496979059 5.010286909007529 0.9999920325206977 1.6294379074202152 0.8021576765695914 0.1473588986629369 1.604157096533516e-05 3.0740534683276367e-06 0.1426818494034091 0.04755988003366744 9.121274021803299e-11 10.039944496979059 0.6294458748995175 YK(ub)EALLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKEALLGR 8 1 P52565;J3KTF8;J3QQX2;J3KRE2;J3KRY1;P52565-2;J3KS60 P52565 ARHGDIA Rho GDP-dissociation inhibitor 1 1 25761100.0 4267100.0 4590000.0 16904000.0 True False 5523845.067115988 4334562.465065722 13827645.449687 1.0 0.7847002246442092 2.5032645343375726 22.39724142475684 -6.87549744683685 1.1046468039078734 0.8730871304088772 2.614992255542494 0.9698664407117784 0.1327031428995464 0.13169101303932834 0.2970494718955787 0.09288728450246983 0.222262270473951 1.331994872922047e-07 6.87549744683685 1.7419051251336166 up YK(ub)EETIEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKEETIEK 8 1 P61254 P61254 RPL26 60S ribosomal protein L26 1 5134800.0 1305900.0 2710800.0 1118100.0 True False 1712047.5463535874 2306359.2066156366 1002409.7375725334 1.0 1.3471350205944026 0.5855034456884802 20.707291337614652 -6.782771311779201 1.5248815381719136 1.1958508641934658 0.5789177196183652 0.7771205990805911 0.14698389108490884 0.2463007261852379 1.1313394075263765 0.075902559477839 0.17870223735480234 1.6490304996755268e-07 6.782771311779201 -0.6169331445751005 YK(ub)EETIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKEETIEK 8 1 P61254 P61254 RPL26 60S ribosomal protein L26 1 6669800.0 2697500.0 2383700.0 1588600.0 True False 2611869.3390368456 3335523.8408312877 1172498.0030215504 1.0 1.2770638220598345 0.44891143117209736 21.31665129597937 -6.816481512383498 1.3869160213648026 1.149889494690918 0.4321438517170337 0.8761258546905647 0.12114588127411487 0.198091363428475 0.7496255286322848 0.06865558117331125 0.15841622427093655 1.5258733488008106e-07 6.816481512383498 -0.7177456429738842 down YK(ub)EETIEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKEETIEK 8 1 P61254 P61254 RPL26 60S ribosomal protein L26 1 4057870.0 1305900.0 1944000.0 807970.0 True False 1788726.5206205426 1858107.6520516684 617144.1266644844 1.0 1.0387880039968638 0.34501871557782104 20.770501399137544 -6.893667583917183 1.0004654690987422 1.034066207363005 0.2808849370693138 0.9831427727592914 0.04132630374725308 0.11621665573940582 0.20488366731261135 0.03131329410922477 0.07916658194223325 1.277416189907219e-07 6.893667583917183 -0.7531812702936911 down YK(ub)EETIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKEETIEK 8 1 P61254 P61254 RPL26 60S ribosomal protein L26 1 7968820.0 2697500.0 4652500.0 618820.0 True False 2243090.769512021 4627436.059051057 748212.400899598 1.0 2.0629731627212506 0.3335631402301075 21.097056571413646 -6.740386012323651 1.6851229975002002 1.6321739862379048 0.33243089532587716 0.6067463239185071 0.4466128410475857 0.31711651571498156 1.7682506168294672 0.20964769874280387 0.5142706043278353 1.8180841793502714e-07 6.740386012323651 -1.2997430909120276 YK(ub)ENPDIVNQSQQAQAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKENPDIVNQSQQAQAR 17 1 O95376 O95376 ARIH2 E3 ubiquitin-protein ligase ARIH2 1 1861560.0 1093200.0 768360.0 0.0 True False 1058496.9643874269 1075170.1549444662 0.0 1.0 1.0157517603904405 0.0 20.013585701239837 -7.011878109558227 1.1040544722594354 1.0270131431597518 4.999223791628263e-21 0.9846999913816076 0.058774156730605376 0.08969738894597633 0.2131462341652665 0.04485990452266405 0.08173731591725202 9.730202763582266e-08 7.011878109558227 -1.0270131431597518 down YK(ub)ESFDVGCNLFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKESFDVGCNLFAK 14 1 O15247;A6PVS0 O15247 CLIC2 Chloride intracellular channel protein 2 1 20475300.0 7083100.0 9537700.0 3854500.0 True False 9286012.692837963 8114712.337663416 3455673.31497481 1.0 0.8738640152755835 0.372137474853989 23.14662782221689 -6.945003259960133 0.6112461676252605 1.0055400824310439 0.21427709040985413 0.9987485096551629 0.009593400711734056 0.08555640304696654 0.04475965374759375 0.00974000139355202 0.04232550018603112 1.1350022959321917e-07 6.945003259960133 -0.7912629920211898 down YK(ub)ESFDVGCNLFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKESFDVGCNLFAK 14 1 O15247;A6PVS0 O15247 CLIC2 Chloride intracellular channel protein 2 1 22340500.0 10916000.0 8732600.0 2691900.0 True False 10569477.555116307 12219572.719907409 1986810.6347310236 1.0 1.1561188957719437 0.18797623859556611 23.333400730878132 -6.865572302727709 1.1571641837817939 1.086333351809578 0.1358282202057949 0.9600661722264936 0.08481022407408251 0.1411762978899083 0.3560883239716306 0.0570168039543471 0.13405430896818976 1.3627861063521053e-07 6.865572302727709 -0.950505131603783 down YK(ub)ESFDVGCNLFAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YKESFDVGCNLFAK 14 1 O15247;A6PVS0 O15247 CLIC2 Chloride intracellular channel protein 2 1 62441000.0 21007000.0 12024000.0 29410000.0 True False 31869154.81741455 9878223.256059201 23597100.609139107 1.0 0.3099618836035575 0.7404369756377954 24.925657422991776 -10.12103429314738 5.640827074835957 1.0000052289883579 0.5251994296213479 0.6186195125974763 0.17574072041046213 1.15569056639253e-05 1.8007601693973277e-06 0.1701620938552002 0.05672007361665388 7.567731356677916e-11 10.12103429314738 -0.47480579936700995 YK(ub)ESFDVGCNLFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKESFDVGCNLFAK 14 1 O15247;A6PVS0 O15247 CLIC2 Chloride intracellular channel protein 2 1 23449600.0 7083100.0 11017000.0 5349500.0 True False 9701913.483580187 10530232.511652905 4086058.276410832 1.0 1.085376872250468 0.4211600405761401 23.20983788373978 -6.87461173076076 1.1094827908656977 1.049927110595982 0.37870559290835837 0.9690696138711453 0.051891822723224915 0.1325064214986088 0.30208309693163266 0.03618841749661096 0.08642841533475995 1.3347141640298476e-07 6.87461173076076 -0.6712215176876236 down YK(ub)ESFDVGCNLFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKESFDVGCNLFAK 14 1 O15247;A6PVS0 O15247 CLIC2 Chloride intracellular channel protein 2 1 20891300.0 10916000.0 6445500.0 3529800.0 True False 9077137.660794534 6410776.812168417 4267864.860048797 1.0 0.7062553253827455 0.4701773862571591 23.11380600631241 -7.240744006343569 0.16823528514506245 1.2330253865094418 3.279434481690364e-14 0.9999928359246021 0.0005800550567218672 0.098158410892343 0.008621158491514881 0.018459557353477027 0.041025097193397024 5.744549732927603e-08 7.240744006343569 -1.233025386509409 down YK(ub)ESFDVGCNLFAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKESFDVGCNLFAK 14 1 O15247;A6PVS0 O15247 CLIC2 Chloride intracellular channel protein 2 1 33591000.0 21007000.0 12584000.0 0.0 True False 27193975.60987685 11883689.337774957 0.0 1.0 0.4369971315800843 0.0 24.696783745084225 -8.139753593735685 0.5565124338358899 1.0226028469089525 1.916758388171614e-16 0.9907245931208432 0.03942185646754466 0.11997330608609098 0.1706228302185431 0.050888119285008866 0.07409201609239882 7.248471009371232e-09 8.139753593735685 -1.0226028469089523 YK(ub)FEVYEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKFEVYEK 8 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 3951780.0 2531700.0 695180.0 724900.0 True False 3319083.2170176716 591461.853790416 649894.3017318046 1.0 0.17820036893255967 0.19580536528871986 21.662353370862608 -10.036219944597594 5.266971776335998 1.0000063147008158 0.18700286710936767 0.9996484373838845 0.007187209678239524 8588033.636858223 16364504.925797733 462.7945136264348 0.002460373867582495 9.199835362317109e-11 10.036219944597594 -0.8130034475914482 YK(ub)FEVYEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKFEVYEK 8 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 6875260.0 753960.0 1371400.0 4749900.0 True False 626951.1460913019 1364011.995998414 5743082.128943796 1.0 2.1756272470387588 9.16033436536288 19.257993502730805 -6.936043714210749 0.6953969408544198 0.9137151847833503 10.843147183870741 0.9975983752903822 0.17651313939743565 0.08961893306004619 0.06318216586863024 0.16704987160183876 0.6123670921087367 1.1586607244906785e-07 6.936043714210749 9.92943199908739 YK(ub)FLNNFDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKFLNNFDR 9 1 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 1 3885200.0 1256200.0 1059300.0 1569700.0 True False 1646890.3650581052 901256.5691190601 1407282.5016256224 1.0 0.5472474599651095 0.8545089166126556 20.651313086105738 -9.958872807776219 5.487550185851982 1.0000005789090851 0.700878188288265 0.5582310098849743 0.12543896440397156 8.88484274498962e-07 1.68531966149972e-07 0.12145599029631891 0.04048525167485866 1.0993277534193899e-10 9.958872807776219 -0.29912239062082013 YK(ub)FLNNFDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKFLNNFDR 9 1 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 1 7605900.0 1139100.0 1892300.0 4574500.0 True False 1102939.8940118162 2647905.258214138 3376301.2179416297 1.0 2.4007702256400294 3.0611833303632934 20.072922741056875 -9.29654929541377 0.23577457045762396 6.866130117457403e-19 3.5416662995308705 0.9992308968117176 0.023832887968672736 0.7170845942915369 0.0884600798954109 0.8577924880361846 0.3057426718760876 5.051852996760126e-10 9.29654929541377 3.5416662995308705 YK(ub)FLNNFDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YKFLNNFDR 9 1 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 1 27540800.0 3720900.0 4458900.0 19361000.0 True False 5644877.33422753 3663174.4574552914 15534289.863772262 1.0 0.648937831694544 2.751926914262707 22.428510800238406 -6.863998899375961 1.1654438274838124 0.8071182653941388 2.8617838626574392 0.9583139393189262 0.18780654089462293 0.14273455164266344 0.36615931229790655 0.12547115619645902 0.29431923034373836 1.3677322918087408e-07 6.863998899375961 2.0546655972633006 up YK(ub)FLNNFDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKFLNNFDR 9 1 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 1 6411300.0 1256200.0 1396800.0 3758300.0 True False 1720651.0875285463 1335084.7574000894 2870666.944618158 1.0 0.7759183526962086 1.6683608695714334 20.71452314762863 -6.840183750033778 1.281479648747011 0.880795485217017 1.697832840012772 0.9247828205027039 0.10396785288416355 0.16858089472131071 0.5376791883225052 0.06361453383560339 0.14656785467574768 1.444828334409344e-07 6.840183750033778 0.817037354795755 YK(ub)FLNNFDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKFLNNFDR 9 1 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 1 5486900.0 1139100.0 1401000.0 2946800.0 True False 947212.1206862452 1393452.5349232724 3562962.2555362377 1.0 1.4711092737218467 3.761525193485604 19.85332801649115 -6.940432601279152 0.6555258616762234 0.9744697890796038 4.387119495754192 0.9982200247076416 0.05088870595115039 0.08756982016810116 0.05371492148163322 0.04970024702545159 0.19675877635432482 1.147010513651854e-07 6.940432601279152 3.412649706674588 up YK(ub)FLNNFDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKFLNNFDR 9 1 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 1 19851500.0 3720900.0 5984600.0 10146000.0 True False 4816778.399904351 5651551.749113794 8299532.10675131 1.0 1.173305325656256 1.7230462806667872 22.199637122330856 -6.9501902446671835 0.5567503939924255 0.9926840763303417 1.9297944343060556 0.999216133297852 0.008629674990866193 0.08340942355783906 0.03564680202179834 0.009287252417058687 0.04566679632835733 1.1215270566674026e-07 6.9501902446671835 0.9371103579757138 YK(ub)GNGGVYGWDLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKGNGGVYGWDLK 13 1 Q5QPK2;H0Y368;O60762 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 1 12297000.0 4789400.0 4128200.0 3379400.0 True False 4637363.11858501 5776611.7882786 2494233.760173125 1.0 1.2456673416683417 0.5378560393895111 22.14487326754213 -6.812935746646101 1.401912219422714 1.1334287523934639 0.5245925487451412 0.867430059930294 0.10683941007253957 0.2028103976761947 0.7849817222095417 0.059911720877328455 0.1384290911026393 1.5383822252941932e-07 6.812935746646101 -0.6088362036483227 YK(ub)HPSEEELR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKHPSEEELR 10 1 K7EQ34;U3KQT6;K7EPA3;Q9NX61-2;Q9NX61;K7EQE7 K7EQ34 TMEM161A Transmembrane protein 161A 1 9098470.0 602070.0 1173300.0 7323100.0 True False 582957.6174064558 1641804.808678671 5404960.421709122 1.0 2.816336487690073 9.271618142251016 19.15303147384855 -6.947592643306436 0.5846760310906368 0.9241132523911223 11.48570495341069 0.998998569631077 0.11232472496714978 0.08446706498588574 0.040075831990325654 0.11709997392713789 0.539950641304008 1.1282552334684157e-07 6.947592643306436 10.561591701019568 YK(ub)LLGGLAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKLLGGLAVR 10 1 P23396;P23396-2;E9PL09;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 1 27573400.0 1975400.0 4810000.0 20788000.0 True False 1912692.00827929 6730658.083818629 15342999.173367705 1.0 3.518945054762744 8.021677879634519 20.867173151371496 -6.9621803082526155 0.40353334717440065 0.7619219333770139 10.944055223331583 0.9998427076652286 0.036426802483241906 0.07893129161802705 0.01831984370026317 0.057925645003620616 0.3767702086742601 1.0909872916567682e-07 6.9621803082526155 10.18213328995457 YK(ub)LLGGLAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YKLLGGLAVR 10 1 P23396;P23396-2;E9PL09;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 1 72255900.0 7583800.0 13261100.0 51411000.0 True False 11505179.050045636 10894553.095552796 41249593.315758266 1.0 0.9469259929083488 3.5853065072980894 23.45578009997718 -6.9023093434047915 0.9465391148853453 0.8971476508814364 3.8756266530727568 0.9876809977245152 0.13667714596086533 0.10972578526433271 0.16798210134292554 0.10780821030645103 0.2838968714642467 1.252248893443939e-07 6.9023093434047915 2.97847900219132 up YK(ub)LLGGLAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKLLGGLAVR 10 1 P23396;P23396-2;E9PL09;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 1 29022200.0 1975400.0 5857800.0 21189000.0 True False 1642632.625058034 5826242.868717735 25619521.933133323 1.0 3.5468934318237437 15.596623092901366 20.647578426805772 -6.94104560112659 0.6497653742269427 0.8668068682602388 18.948479532349367 0.99829764416436 0.2626624731613938 0.08729291151383116 0.052462015878357825 0.25775463634921875 1.0324122937374167 1.1453926683578313e-07 6.94104560112659 18.08167266408913 YK(ub)LLGGLAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKLLGGLAVR 10 1 P23396;P23396-2;E9PL09;F2Z2S8;H0YCJ7;H0YF32 P23396 RPS3 40S ribosomal protein S3 1 59532100.0 7583800.0 12069300.0 39879000.0 True False 9817378.599047186 11397632.845232625 32621431.193094436 1.0 1.1609649898129435 3.3228250152500456 23.22690642206963 -6.921833198854314 0.8110133155962206 0.955378108538933 3.686582277763185 0.9946751962281677 0.07728320033703015 0.09710516400441324 0.10011241818071992 0.06724204469457636 0.2050917570557465 1.1972002563069952e-07 6.921833198854314 2.731204169224252 up YK(ub)LLPEYPGVLSDVQEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKLLPEYPGVLSDVQEEK 18 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 31597100.0 5816100.0 11140000.0 14641000.0 True False 7624963.423192512 9477955.423379889 13126089.766388929 1.0 1.2430165100269481 1.7214626533766555 22.862298986322426 -6.9603519356979895 0.43045310303882206 0.9810864564394394 2.0017538077899792 0.9997830099812715 0.004415011556234313 0.0795757563691141 0.02066927967804882 0.006241544572501225 0.03972163236374767 1.0955900119216778e-07 6.9603519356979895 1.0206673513505398 YK(ub)LLPEYPGVLSDVQEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKLLPEYPGVLSDVQEEK 18 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 98630000.0 26214000.0 23179000.0 49237000.0 True False 25381850.918818142 32434495.57688816 36340352.62166184 1.0 1.2778617162565231 1.4317455704035773 24.597293942769365 -11.687884347992721 0.09047828182409097 2.915478202064987e-20 1.8670254512594333 0.9999016644281122 0.0017717124466974789 4.915003332579886 0.06385675326356505 1.281814732972914 0.31192289440509563 2.0517084731528878e-12 11.687884347992721 1.8670254512594333 YK(ub)LLPEYPGVLSDVQEEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YKLLPEYPGVLSDVQEEK 18 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 547617000.0 28477000.0 62510000.0 456630000.0 True False 43201690.94756579 51354602.107140824 366376880.3519607 1.0 1.1887174085262147 8.480614353651923 25.36458444590409 -6.912455303924372 0.8788405681963519 0.7913780751706532 9.47421354627505 0.9918157133010528 0.3150756083850225 0.10281708773600848 0.13012348726167047 0.2611293748109206 0.7337153751516884 1.2233330137449616e-07 6.912455303924372 8.682835471104397 up YK(ub)LLPEYPGVLSDVQEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKLLPEYPGVLSDVQEEK 18 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 35488100.0 5816100.0 11922000.0 17750000.0 True False 7966469.344192618 11395246.619218117 13557815.572724963 1.0 1.4304011133269474 1.7018600068558996 22.925509047845317 -9.091923759663514 0.09854813295028467 8.49414030984415e-15 2.542746617935254 0.9999632026578132 0.0017529171632337563 0.5619696518765565 0.03329034919506681 0.49119335162085204 0.3406228153219876 8.092379483200414e-10 9.091923759663514 2.5427466179352454 YK(ub)LLPEYPGVLSDVQEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKLLPEYPGVLSDVQEEK 18 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 61630000.0 26214000.0 16259000.0 19157000.0 True False 21798102.477104053 16171409.539841171 23162640.12803982 1.0 0.7418723513584287 1.0625989189824676 24.37769921820364 -6.692504186492972 1.857782217759834 0.8385502609132545 1.061517442809301 0.3820870201694686 0.10911501850179374 0.41128868529115387 2.7541404579753066 0.04695564423043114 0.12187930726507903 2.0299989510701697e-07 6.692504186492972 0.22296718189604658 YK(ub)LLPEYPGVLSDVQEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKLLPEYPGVLSDVQEEK 18 1 P00374;P00374-2 P00374 DHFR Dihydrofolate reductase 1 713899000.0 28477000.0 49922000.0 635500000.0 True False 36864037.86559067 47143796.81503506 519845520.78064865 1.0 1.2788560218749025 14.10169777592049 25.13571076799654 -6.911594510036488 0.8848219561871561 0.6227217804864222 15.816531674484194 0.9915091582894417 0.563151869922884 0.10337264302841323 0.13312347550248868 0.4647263318682107 1.297452847037718 1.225760126918193e-07 6.911594510036488 15.193809893997772 up YK(ub)PLDLRPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKPLDLRPK 9 2 P42766 P42766 RPL35 60S ribosomal protein L35 1 12188400.0 2305000.0 2478200.0 7405200.0 True False 3021877.321651752 2108462.219947939 6638980.939694243 1.0 0.6977325667196369 2.1969723562654053 21.52701366230966 -6.8542490427015865 1.2144526976463241 0.8379125828337807 2.2619881559882407 0.9462567340806397 0.15007789635803162 0.15284622458270786 0.4316836428508131 0.09658350151668897 0.22418811663402347 1.398784970475311e-07 6.8542490427015865 1.42407557315446 up YK(ub)PLDLRPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YKPLDLRPK 9 2 P42766 P42766 RPL35 60S ribosomal protein L35 1 17787700.0 4142500.0 5848600.0 7796600.0 True False 6284475.3573161205 4804871.634679629 6255598.5926288245 1.0 0.7645620933314664 0.9954050635820094 22.583360879444697 -10.77629329485097 9.042064167537507 1.0011388598726962 0.8799835784692586 0.26492297507931617 0.09424124797038458 0.002182933524022152 5.4007125957345546e-05 0.09206323375134276 0.030416231992925237 1.6738121080825717e-11 10.77629329485097 -0.12115528140343768 YK(ub)PLDLRPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKPLDLRPK 9 2 P42766 P42766 RPL35 60S ribosomal protein L35 1 12042800.0 2305000.0 1775000.0 7962800.0 True False 3157220.7902828357 1696574.6308599343 6082150.639013764 1.0 0.5373633152554873 1.9264254998361716 21.59022372383255 -6.816921500155446 1.3851867314729327 0.7498394856726619 1.954782682319374 0.8771444108528353 0.20242605232687177 0.19751347806978237 0.7454929142862081 0.11486263477913328 0.26497592485366755 1.524328255150249e-07 6.816921500155446 1.204943196646712 YK(ub)PLDLRPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKPLDLRPK 9 2 P42766 P42766 RPL35 60S ribosomal protein L35 1 15465000.0 2102600.0 4992100.0 8370300.0 True False 1748405.0609734852 4965206.566445738 10120491.03010551 1.0 2.8398491157885273 5.78841325503289 20.73760802862467 -6.964134213234608 0.3726122935009345 0.7798631301208301 7.951457062308433 0.9998941713848548 0.020289147068335102 0.0782559870045675 0.015903402232883 0.038716849617589935 0.2500735970897238 1.0860899293480504e-07 6.964134213234608 7.171593932187602 YK(ub)PLDLRPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKPLDLRPK 9 2 P42766 P42766 RPL35 60S ribosomal protein L35 1 18054700.0 4142500.0 6261100.0 7651100.0 True False 5362547.910882792 5912664.281050768 6258678.306915531 1.0 1.1025848867572008 1.1671090703383973 22.354487201537147 YK(ub)QEIGFGNWGH ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKQEIGFGNWGH 12 1 Q9NPA3 Q9NPA3 MID1IP1 Mid1-interacting protein 1 1 7845200.0 1623000.0 4460400.0 1761800.0 True False 1349596.4110910138 4436370.939879918 2130184.2343571824 1.0 3.287183415294914 1.5783861136939015 20.364096611586238 -6.571702667441831 2.2996260088498044 2.565190492233117 1.5820146606511738 0.0 0.9956973049486336 0.724594163106533 7.195503801917741 0.36548565674999145 1.1156394455400007 2.681003201286775e-07 6.571702667441831 -0.983175831581943 YK(ub)RPGYGAYDAFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKRPGYGAYDAFK 13 2 P05198;H0YJS4;G3V4T5 P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 1 5055200.0 1463200.0 1752900.0 1839100.0 True False 1918269.369648958 1491374.152750682 1648807.5738928989 1.0 0.7774581486559432 0.859528698096571 20.871373891854315 -10.913062449107503 10.493706338300527 1.0222123872755278 0.8184934233762571 0.8670481346414416 0.033505161506566225 0.015181730481501978 0.00012577638004951353 0.02828660177118372 0.0108137443772434 1.221623984866221e-11 10.913062449107503 -0.2037189638992707 YK(ub)RPGYGAYDAFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKRPGYGAYDAFK 13 2 P05198;H0YJS4;G3V4T5 P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 1 6519500.0 2348300.0 1458100.0 2713100.0 True False 2273754.5018944317 2040326.933891052 2002457.7187446563 1.0 0.8973382712122641 0.8806833442556186 21.116645063651443 -13.999999999999998 0.2559529772621074 1.7359427301415729 0.8743559135490092 0.9995541790027539 0.0011140007515882473 14.24190856977377 0.16008781786648538 5.4080570430163455 0.007439874628503462 1.0000000000000041e-14 13.999999999999998 -0.8615868165925636 YK(ub)RPGYGAYDAFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YKRPGYGAYDAFK 13 2 P05198;H0YJS4;G3V4T5 P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 1 31944500.0 3312400.0 9307100.0 19325000.0 True False 5025152.968877226 7646175.288295801 15505405.2795516 1.0 1.5215806037451218 3.085558862701842 22.260736082845913 -6.95146214817816 0.5425603229184116 0.9773540228966298 3.7023268095849096 0.9993110502044752 0.023259984727931768 0.08290399755066451 0.03357405991398749 0.025494322875860346 0.12957350680951457 1.1182472834610545e-07 6.95146214817816 2.72497278668828 YK(ub)RPGYGAYDAFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKRPGYGAYDAFK 13 2 P05198;H0YJS4;G3V4T5 P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 1 8575700.0 2348300.0 3554100.0 2673300.0 True False 1952715.4973290395 3534953.357866388 3232274.6700573545 1.0 1.8102756713415562 1.6552716842154014 20.89705033908572 -10.087588498265236 4.533338816659114 0.99995230361798 1.7327736777491738 0.96753076393023 0.06328011295218373 43994297.95249213 2.3170489797858407 24588.218256857595 0.021662465786146588 8.173564643336356e-11 10.087588498265236 0.7328213741311937 YKAEDEVQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKAEDEVQR 9 1 P0DMV9;P0DMV8;A0A0G2JIW1;P0DMV8-2;V9GZ37;Q53FA3;P34931 P0DMV9;Q53FA3 HSPA1B;HSPA1A;HSPA1L Heat shock 70 kDa protein 1B;Heat shock 70 kDa protein 1A;Heat shock 70 kDa protein 1-like 0 15789600.0 4143900.0 1714800.0 9930900.0 False True 4012354.1627561743 2399528.5825638627 7329699.369386072 1.0 0.5980350899322341 1.826782749494661 21.936017524800963 -6.818589467928573 1.3779091188449122 0.7830222767005494 1.8528145724986564 0.8811061017909984 0.17638062536502602 0.19533174895766114 0.7290965924103586 0.1005979800713356 0.23196036866650627 1.518485090462465e-07 6.818589467928573 1.069792295798107 YKDAIHFYNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKDAIHFYNK 10 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 31040200.0 9886600.0 8002600.0 13151000.0 False True 12961428.341970583 6808643.273890479 11790260.673299717 1.0 0.5253003831254704 0.9096420828190291 23.627721375360895 -9.94894098561836 6.831533866418555 1.0000000186516569 0.7174712329722487 0.418770858493027 0.15690684185387632 4.459918270908873e-08 6.959030742447781e-09 0.15192440540690033 0.05064146545050453 1.1247578020117603e-10 9.94894098561836 -0.2825287856794082 YKDAIHFYNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKDAIHFYNK 10 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 21539900.0 5328800.0 1750100.0 14461000.0 False True 5159640.160837646 2448924.056650932 10673230.27929914 1.0 0.4746307843788392 2.068599736917775 22.298839023291062 -6.817890022685977 1.380929499849334 0.7162069810673908 2.1018606569340217 0.8794677187417309 0.23025245699707553 0.1962409696178308 0.7358875860984493 0.1310434603352241 0.30222445360169997 1.5209326299706629e-07 6.817890022685977 1.385653675866631 up YKDAIHFYNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YKDAIHFYNK 10 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 60941600.0 10086000.0 44760000.0 6095600.0 False True 15301199.385368839 36772228.288523756 4890801.988203612 1.0 2.403225221918599 0.3196352040795081 23.867141407293207 -6.725259705467707 1.7401150236088367 1.848889038750136 0.3218285827407762 0.5372444589811711 0.5901388724079328 0.34524334716074995 2.045655440424093 0.2689775568688421 0.6711631290690189 1.8825230154782776e-07 6.725259705467707 -1.5270604560093597 YKDAIHFYNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKDAIHFYNK 10 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 28175900.0 9886600.0 8621800.0 9667500.0 False True 13541943.195318986 8240860.367520108 7384235.608412327 1.0 0.6085434157166387 0.5452862637147097 23.690931436883787 -13.999999999999998 0.2565127542453019 3.8143046257992013 0.521382125170108 0.9995553020994629 0.0042409596801237575 14.265730349796474 0.16026398704731043 20.767711520540317 0.02817257899049968 1.0000000000000041e-14 13.999999999999998 -3.292922500629093 YKDAIHFYNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKDAIHFYNK 10 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 13287000.0 5328800.0 4725200.0 3233000.0 False True 4431133.30586679 4699744.409721232 3909005.3522969526 1.0 1.0606190528050246 0.8821683037884364 22.07924429872534 -6.815031915846158 1.3930929913700958 1.032846810413124 0.8786682295386287 0.8726006710168812 0.026444893111781415 0.20001910607164555 0.7640220212646273 0.014921575281015237 0.03444788477096533 1.530974947803986e-07 6.815031915846158 -0.15417858087449543 YKDAIHFYNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKDAIHFYNK 10 1 P31948;P31948-2;P31948-3 P31948 STIP1 Stress-induced-phosphoprotein 1 0 31708000.0 10086000.0 10072000.0 11550000.0 False True 13056525.824783068 9511484.346000433 9448018.513007851 1.0 0.728485086587608 0.7236242350989129 23.638267729385657 YKDLEQQDCEIAQEIQEK(ub)LAIEAER ddPTM_RPMI8226_Bortezomib_8h_R1 1 YKDLEQQDCEIAQEIQEKLAIEAER 25 2 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 23732800.0 2336200.0 13066000.0 8330600.0 True False 3544186.199097626 10734270.214876056 6684053.25856831 1.0 3.028698158581249 1.8859204576413384 21.757022969339634 -10.453350381655492 5.998053385864229 0.99923313645659 2.4573093081112933 0.6843729898022216 0.46653704278894326 0.004786254173139477 0.00043620806054486924 0.45190914544450234 0.150574183092536 3.5208669865900964e-11 10.453350381655492 1.4580761716547035 YKDLEQQDCEIAQEIQEK(ub)LAIEAER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKDLEQQDCEIAQEIQEKLAIEAER 25 2 Q8IVM0;Q8IVM0-2 Q8IVM0 CCDC50 Coiled-coil domain-containing protein 50 1 22195400.0 2336200.0 10715000.0 9144200.0 True False 3024256.953386693 10118700.830758005 7480049.427415279 1.0 3.345846925945446 2.4733511545832103 21.528149291432083 -10.289983665832489 5.908191366053268 0.9998780926798547 2.9095990402643346 0.864626921984219 0.35619490709560525 0.0005720061318718114 6.874152455997626e-05 0.3449052860275511 0.1149614119320947 5.128806734864955e-11 10.289983665832489 1.9097209475844799 YKEAMSNK(ub)ACR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YKEAMSNKACR 11 2 Q9UHC7-2;Q9UHC7 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 2864720.0 538120.0 1286300.0 1040300.0 True False 816367.3818416294 1056749.7150922287 834684.2490203131 1.0 1.2944536229611783 1.0224370394825955 19.638859014725842 -10.574905408708313 3.094113457013641 0.9923551568542514 1.1584453310124803 0.311476654688832 0.11105030654596273 81575125.1716348 106574387.50584856 5250369.738575964 0.04064024612099234 2.6613046408006006e-11 10.574905408708313 0.1660901741582289 YKEAMSNK(ub)ACR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKEAMSNKACR 11 2 Q9UHC7-2;Q9UHC7 Q9UHC7-2 MKRN1 E3 ubiquitin-protein ligase makorin-1 1 2689720.0 538120.0 1146700.0 1004900.0 True False 696606.9479310192 1082885.136969689 822018.511144727 1.0 1.5545138333545887 1.180032030381251 19.40998533681829 -10.428800738022986 5.526904752312456 0.99974412667886 1.3672729318679215 0.5618826339755968 0.1528815558736959 0.00048234933523528894 4.98502651323611e-05 0.14812847422755465 0.04934230998675775 3.725626053478066e-11 10.428800738022986 0.3675288051890615 YKEETIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKEETIEK 8 1 P61254 P61254 RPL26 60S ribosomal protein L26 0 8943700.0 3006800.0 1269900.0 4667000.0 False True 2911350.7798391054 1776977.6924410157 3444572.6930011143 1.0 0.6103619339677164 1.1831527539912168 21.47325724521418 -6.723534315096348 1.7465743595673595 0.7638498343107393 1.18244451317502 0.5291657398161691 0.16389387785876083 0.3484884648775257 2.0794117483197763 0.07445414070804433 0.18613693496563852 1.890016888571111e-07 6.723534315096348 0.4185946788642808 YKEETIEK(ub)MQE ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKEETIEKMQE 11 2 P61254 P61254 RPL26 60S ribosomal protein L26 1 15835600.0 7538200.0 5206400.0 3091000.0 True False 9758348.500136798 4916659.263206573 2528469.7163382927 1.0 0.5038413275707102 0.2591083641153877 23.218205576511163 -9.73182354786447 0.18524312765763246 1.5815372990603618 7.54419737921332e-21 0.9995575713201102 0.006483062910125926 1.1884932331241012 0.07870386308128254 0.5181839885612787 0.1564638773841278 1.8542848590127038e-10 9.73182354786447 -1.5815372990603618 YKETDLLILFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKETDLLILFK 11 1 P05455 P05455 SSB Lupus La protein 0 3692300.0 1112000.0 1308800.0 1271500.0 False True 1457842.7686233176 1113532.1416624417 1139937.3770892376 1.0 0.7638218370517293 0.7819343770286784 20.475403699716466 -10.50439614852402 6.148879222926573 1.0002036342259144 0.7728781070402039 0.9952528204202132 0.007394413481547876 2.066036058338713e-05 1.6652300282605184e-06 0.007165969670402398 0.0023865366890838753 3.1304289517164207e-11 10.50439614852402 -0.22732552718571053 YKETDLLILFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKETDLLILFK 11 1 P05455 P05455 SSB Lupus La protein 0 4828800.0 1796400.0 1153300.0 1879100.0 False True 1739374.2652996476 1613818.7043800473 1386907.3382083545 1.0 0.9278156728977645 0.7973599275768447 20.730136963496204 -6.961977733752364 0.4066101571831714 1.0066688466027465 0.7136920986102904 0.9998366408987263 0.0010718141226668744 0.07900215608856183 0.01857624176819883 0.0016786698410594853 0.01090432328292047 1.0914962959527865e-07 6.961977733752364 -0.2929767479924561 YKETDLLILFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKETDLLILFK 11 1 P05455 P05455 SSB Lupus La protein 0 4985400.0 1112000.0 2123800.0 1749600.0 False True 1523136.45067007 2029963.4935325817 1336380.5141430763 1.0 1.3327522249497374 0.8773872580852263 20.538613761239358 -6.710805076847351 1.7922348712645135 1.2044025008476418 0.8784284755574416 0.4689172233979144 0.14020292237131207 0.37348809868202953 2.339052074667384 0.062239946222766726 0.15797046196243067 1.9462334080068335e-07 6.710805076847351 -0.32597402529020014 YKGNGGVYGWDLK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKGNGGVYGWDLKR 14 2 Q5QPK2;H0Y368;O60762 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 1 9057600.0 3186400.0 2271800.0 3599400.0 True False 3085249.4761471776 3178941.5872804946 2656609.1603145944 1.0 1.0303677585419506 0.8610678588080132 21.556955721080815 -6.860501767865848 1.1830857516348603 1.0165004878035804 0.8527862617792011 0.9542547730262168 0.015763309449421458 0.14629175086662793 0.38878701955429584 0.010389288035789875 0.02426736621672728 1.3787903403686113e-07 6.860501767865848 -0.16371422602437924 YKGNGGVYGWDLK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 YKGNGGVYGWDLKR 14 2 Q5QPK2;H0Y368;O60762 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 1 43748900.0 11611000.0 9798900.0 22339000.0 True False 17614735.877802666 8050209.735844856 17923686.85846846 1.0 0.4570156368900986 1.0175393478965031 24.070279506876314 -10.90004483595168 12.205535999246239 1.0158303649664266 0.7372774923933009 0.22655544596148636 0.22883284678282506 0.08726046965914334 0.000714603305020637 0.19613414080266947 0.07385548372125951 1.2587954488134536e-11 10.90004483595168 -0.2785528725731258 YKGNGGVYGWDLK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKGNGGVYGWDLKR 14 2 Q5QPK2;H0Y368;O60762 Q5QPK2 DPM1 Dolichol-phosphate mannosyltransferase subunit 1 1 43723000.0 11611000.0 15889000.0 16223000.0 True False 15030668.387027197 15004763.182446491 13270580.46203694 1.0 0.9982765101382275 0.882900222420623 23.841405828968764 -6.910148380533607 0.8947003943865355 1.0035555559212737 0.8679411777968388 0.9909779597598494 0.005205109983653074 0.10432062806491885 0.13822694568860333 0.0042646188253817816 0.011784771202340243 1.2298485104515099e-07 6.910148380533607 -0.1356143781244349 YKLPVHTEISWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKLPVHTEISWK 12 1 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 0 35906000.0 11117000.0 10341000.0 14448000.0 False True 14574494.65718113 8798163.108902287 12953059.55500221 1.0 0.6036684849698898 0.888748451296731 23.796942525804177 -10.002767578976577 5.364832673200131 1.0000011336840904 0.7462084681327784 0.5137887527653038 0.11638340890029447 1.5780049854007651e-06 2.932811173116316e-07 0.11268825316387078 0.03756258370353767 9.936476757686157e-11 10.002767578976577 -0.25379266555131197 YKLPVHTEISWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKLPVHTEISWK 12 1 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 0 25109100.0 8850400.0 3851700.0 12407000.0 False True 8569448.896464027 5389703.8963501565 9157234.497978322 1.0 0.6289440501330354 1.0685908287237502 23.030770996543684 -6.682929256216874 1.8911511473888734 0.7658568495255563 1.0669722892153652 0.337765006243843 0.1571611809454262 0.43202653207576996 2.989718639262967 0.06661695088988245 0.17506227964790286 2.0752515350765906e-07 6.682929256216874 0.3011154396898089 YKLPVHTEISWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YKLPVHTEISWK 12 1 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 0 19876700.0 6452700.0 0.0 13424000.0 False True 9789217.655559143 0.0 10770740.516051777 1.0 0.0 1.1002657101954663 23.22276213502183 -10.665103174889936 4.26442530285332 1.0167857856748967 0.5501328551017448 0.18227235785088147 0.4491815952441291 0.07238608241133568 0.005684669238077335 0.43917415705557805 0.14497273648350192 2.162204789954932e-11 10.665103174889936 -0.46665293057315194 YKLPVHTEISWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKLPVHTEISWK 12 1 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 0 29962900.0 11117000.0 8937000.0 9908900.0 False True 15227255.325628744 8542133.789293086 7568621.900201375 1.0 0.5609765914226158 0.4970443943014964 23.860152587327068 -13.999999999999998 0.2713526237896726 4.413286753290514 0.4760996231912883 0.9995862432889406 0.004547339437740346 14.949820885706643 0.1649133954807609 28.17247284111646 0.026374204337634467 1.0000000000000041e-14 13.999999999999998 -3.9371871300992254 YKLPVHTEISWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKLPVHTEISWK 12 1 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 0 20463000.0 8850400.0 5750100.0 5862500.0 False True 7359499.739198964 5719123.069994517 7088321.644862621 1.0 0.7771075851165133 0.9631526457033533 22.81117627197796 -10.065524437697485 6.026347586365396 1.0000003034127696 0.8701301154880944 0.3938327475450477 0.07595257793384215 3.096303227948028e-07 4.8006500907607066e-08 0.07354093940617736 0.0245135891199382 8.599546759827447e-11 10.065524437697485 -0.1298701879246752 YKLPVHTEISWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKLPVHTEISWK 12 1 Q8TEQ6 Q8TEQ6 GEMIN5 Gem-associated protein 5 0 18733700.0 6452700.0 0.0 12281000.0 False True 8353147.351732869 0.0 10045984.01370126 1.0 0.0 1.202658541827017 22.99388845711428 -10.756642121908081 6.226262556693128 1.012173187353132 0.6013292709135086 0.12779178328813368 0.490983293712642 0.08297250527165766 0.0032430346849444186 0.4754296971674658 0.15846417665126056 1.7512892348981725e-11 10.756642121908081 -0.4108439164396235 YKPDLK(ub)EGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKPDLKEGSR 10 2 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;P18583-6;P18583-8;P18583-3 P18583-2;P18583-3 SON Protein SON 1 8194600.0 1634400.0 3269800.0 3290400.0 True False 2142714.2275521164 2781958.5855805716 2949940.9717455194 1.0 1.2983339307728132 1.3767309395782548 21.031008020838826 -12.804804167625345 0.2043641586581931 2.5235813362516958e-08 1.4281469358287748 0.9994352144811948 0.0038571213745408643 7.596563678089641 0.13523771102145724 3.1261293911194596 0.04826356979545269 1.5674577099150438e-13 12.804804167625345 1.4281469105929614 YKPDLK(ub)EGSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKPDLKEGSR 10 2 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;P18583-6;P18583-8;P18583-3 P18583-2;P18583-3 SON Protein SON 1 15800100.0 3480600.0 4984400.0 7335100.0 True False 3370110.2581841173 6974696.913302624 5413817.261716829 1.0 2.0695752895220494 1.6064214067090794 21.68436436142369 -10.173974784621416 5.63707013154519 0.9999815131365415 1.8379983481156166 0.8136032862273491 0.1890817808802856 4.393351079040667e-05 6.437808956135534e-06 0.18308167670119585 0.061025882368354524 6.699235044177506e-11 10.173974784621416 0.8380168349790751 YKPDLK(ub)EGSR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKPDLKEGSR 10 2 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;P18583-6;P18583-8;P18583-3 P18583-2;P18583-3 SON Protein SON 1 8279400.0 1634400.0 3568800.0 3076200.0 True False 2238681.84799925 3411118.6155565805 2349664.916327692 1.0 1.523717458380769 1.049575185695828 21.094218082361717 -10.449252360752688 3.6155279137275493 0.9970909802892179 1.2866463220884492 0.3276496760186487 0.19356777263652472 140501114.60102174 103127034.41625825 3763280.363126125 0.07083844852533727 3.5542472760197685e-11 10.449252360752688 0.28955534179923126 YKPDLK(ub)EGSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKPDLKEGSR 10 2 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;P18583-6;P18583-8;P18583-3 P18583-2;P18583-3 SON Protein SON 1 14349000.0 3480600.0 7737100.0 3131300.0 True False 2894273.116724208 7695418.706605885 3786040.3525046236 1.0 2.658843307543727 1.3081144037953594 21.464769636857966 -6.5952269544010695 2.2082830494080774 2.119047904130352 1.3122442739862876 0.0070660142470133636 0.7178794129323259 0.6545563263877096 6.024929160786404 0.27052923875592677 0.7995133750827758 2.539645186305433e-07 6.5952269544010695 -0.8068036301440644 YKPDLK(ub)EGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKPDLKEGSR 10 2 P18583-2;P18583-7;P18583;P18583-5;P18583-9;P18583-10;P18583-4;P18583-6;P18583-8;P18583-3 P18583-2;P18583-3 SON Protein SON 1 5082000.0 1561500.0 1769900.0 1750600.0 True False 2021392.531766682 1671403.5091328595 1432008.7626728616 1.0 0.8268574672491075 0.7084268592905588 20.946918073448906 -7.403882681482697 0.06513691694845383 1.583108648348993 4.866604219608126e-08 0.9999996847088028 6.698139731580161e-05 0.12427105193269336 0.0046030740120277585 0.04805676442045094 0.06236828644876964 3.945638735351258e-08 7.403882681482697 -1.5831085996829508 YKPESEELTAER ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKPESEELTAER 12 1 P07237;H7BZ94;H0Y3Z3;I3L398 P07237 P4HB Protein disulfide-isomerase 0 40325700.0 10693600.0 2913900.0 26718200.0 False True 10354137.521380706 4077435.465787755 19719901.891181145 1.0 0.3937976926970578 1.9045431693813868 23.30370404920897 -6.797812595759213 1.4649516848295219 0.6645987799117351 1.9242607259884386 0.8256568751403669 0.2591926449432775 0.22389437457374822 0.9488484682956225 0.13920859251649265 0.3241709311374115 1.5928959360036403e-07 6.797812595759213 1.2596619460767036 YKPFK(ub)QLHNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKPFKQLHNR 10 2 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 5102900.0 0.0 2500900.0 2602000.0 True False 0.0 2127775.468431847 2332770.000146438 0.0 YKPFK(ub)QLHNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKPFKQLHNR 10 2 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 10331500.0 2224200.0 3284800.0 4822500.0 True False 2153593.9884655285 4596437.770005703 3559342.57810111 1.0 2.134310271399272 1.652745409378302 21.038314857256943 -10.346196076840178 5.2962350215175755 0.9996921005933347 1.893527840388826 0.8211201651792142 0.19659803166766388 0.0007149905719592947 8.826311354554557e-05 0.1904180927491271 0.0634517418788153 4.506132141283221e-11 10.346196076840178 0.8938357397954914 YKPFK(ub)QLHNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKPFKQLHNR 10 2 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 4529800.0 0.0 2291900.0 2237900.0 True False 0.0 2190636.279700218 1709354.110997252 0.0 YKPFK(ub)QLHNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKPFKQLHNR 10 2 P09874 P09874 PARP1 Poly [ADP-ribose] polymerase 1 1 11795020.0 2224200.0 6557700.0 3013120.0 True False 1849520.848766876 6522372.368498467 3643149.460907205 1.0 3.526520056720152 1.969780153241413 20.81872013269122 -9.99953560295044 6.281745111128996 0.9999990924867362 2.7481501049808372 0.6270567318681399 0.6355364042922707 8.07872296527985e-06 1.2860037431639908e-06 0.6153557982573583 0.20511849247768002 1.0010698856433035e-10 9.99953560295044 1.7481510124941009 YKPGVLLGFNMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKPGVLLGFNMK 12 1 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 0 9545500.0 1733100.0 1628000.0 6184400.0 False True 2272110.883364275 1385108.7458942973 5544497.612953742 1.0 0.6096131821891504 2.440240770619478 21.11560181216688 -6.85096185014458 1.2305856358155907 0.7915092701778641 2.5147296983918785 0.9416728445775099 0.1901293755091432 0.156404555671089 0.45531772840946566 0.12087358576519416 0.27986104905792863 1.409412600421726e-07 6.85096185014458 1.7232204282140144 up YKPGVLLGFNMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKPGVLLGFNMK 12 1 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 0 17779980.0 6027900.0 3450980.0 8301100.0 False True 5836547.614005647 4828974.310622953 6126792.882338016 1.0 0.8273682714478547 1.049728930101741 22.47668381977435 -6.699443403953759 1.8326107711211914 0.8927469964190241 1.0490663408166454 0.41507330506504003 0.0728770585360538 0.39666771143784635 2.589530208659843 0.03172814449156644 0.08165992643136717 1.9978211019562455e-07 6.699443403953759 0.1563193443976213 YKPGVLLGFNMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YKPGVLLGFNMK 12 1 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 0 38367400.0 10213600.0 10394200.0 17759600.0 False True 15494777.91417837 8539273.799744727 14249407.275690814 1.0 0.5511065629363383 0.9196264286338697 23.88527874121313 -9.981685372237488 6.92924943394307 1.0000000232535236 0.7353664957851036 0.4074262418124942 0.15044760517299155 5.403978629724766e-08 7.831499471883386e-09 0.1456702803518626 0.04855675577598183 1.0430728173454197e-10 9.981685372237488 -0.26463352746841995 YKPGVLLGFNMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKPGVLLGFNMK 12 1 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 0 12005400.0 1733100.0 2080800.0 8191500.0 False True 2373873.9052664572 1988863.3757145663 6256836.409238116 1.0 0.837813403358223 2.635707143230008 21.17881187368977 -6.884872704753958 1.0522190445526058 0.8911931911912244 2.775670090279864 0.9774092087472819 0.12204722429651255 0.12340270148651232 0.2469295321825459 0.08891908235553625 0.21795998812583633 1.3035488032221066e-07 6.884872704753958 1.8844768990886394 up YKPGVLLGFNMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKPGVLLGFNMK 12 1 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 0 8251160.0 6027900.0 817060.0 1406200.0 False True 5012465.931248021 812658.3356062885 1700229.9184658101 1.0 0.16212745318429525 0.3392002941838412 22.257089095208627 -10.35920083690242 8.536140375548658 1.0000025393647378 0.250663874640638 0.9598029736974973 0.07228968462564406 3.493519790116711e-06 2.623345650371573e-07 0.06999442274910846 0.023331395388142155 4.373198224364631e-11 10.35920083690242 -0.7493386647240998 YKPGVLLGFNMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKPGVLLGFNMK 12 1 Q9H2P0;A0A669KBJ7;A0A2R8Y6X0 Q9H2P0 ADNP Activity-dependent neuroprotector homeobox protein 0 44332800.0 10213600.0 18140300.0 15978900.0 False True 13221706.54015509 17130776.35839474 13070904.157359423 1.0 1.2956554667408156 0.9885943329374561 23.65640506330558 -6.654754919651234 1.9915986778431995 1.1911189512895881 0.9898819731724218 0.21366890907221658 0.12604127460507897 0.49689454422092516 3.783050071296363 0.05123171007092432 0.13964873916907874 2.2143439520295608e-07 6.654754919651234 -0.20123697811716634 YKPLDLRPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKPLDLRPK 9 2 P42766 P42766 RPL35 60S ribosomal protein L35 0 13460100.0 1478900.0 7877600.0 4103600.0 False True 1938852.221687972 6702292.786644289 3678998.8365107356 1.0 3.45683529238203 1.8975137946861083 20.886771415490557 -10.082602038361744 6.250764457098907 0.9999969088014864 2.6771745435340875 0.6066856483541061 0.6365903357179762 2.7424164319860623e-05 4.024633115222758e-06 0.616377079808762 0.20545864738268294 8.267952285442302e-11 10.082602038361744 1.677177634732601 YKPLDLRPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKPLDLRPK 9 2 P42766 P42766 RPL35 60S ribosomal protein L35 0 11287500.0 3991900.0 1520800.0 5774800.0 False True 3865179.319555582 2128063.370867231 4262206.639713482 1.0 0.5505729993173811 1.1027189911084254 21.88210391683326 -6.6902581816855555 1.8655877310218851 0.7183059973587395 1.1008125474012034 0.3716182106034036 0.19006588809737937 0.4161002819162122 2.8080365128369174 0.08149826117518218 0.2121511164332446 2.0405245221907142e-07 6.6902581816855555 0.3825065500424639 YKPLDLRPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKPLDLRPK 9 2 P42766 P42766 RPL35 60S ribosomal protein L35 0 9892900.0 1478900.0 4122400.0 4291600.0 False True 2025689.2957697548 3940258.737046192 3278012.468276422 1.0 1.945144670149875 1.6182207582978756 20.94998147701345 -10.307819875657344 5.729016047960939 0.9999153709495935 1.7816827142238807 0.8840264666687021 0.1334661281253565 0.00014428434223897978 1.7432174757264234e-05 0.12924184895172866 0.04307600762602147 4.922436522049751e-11 10.307819875657344 0.7817673432742872 YKPLDLRPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKPLDLRPK 9 2 P42766 P42766 RPL35 60S ribosomal protein L35 0 5707410.0 3991900.0 916980.0 798530.0 False True 3319441.721154786 912040.0467337205 965498.9310144398 1.0 0.2747570595745946 0.2908618412732839 21.662509192267535 -10.221286869114412 6.091429483551926 1.0000129466621386 0.2828094505562917 0.9996219598257773 0.006574749596792244 1.1560235509915672e-06 1.477753036092886e-07 0.006366088634188412 0.0021219913078204256 6.007767689755197e-11 10.221286869114412 -0.7172034961058469 YKPLDLRPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKPLDLRPK 9 2 P42766 P42766 RPL35 60S ribosomal protein L35 0 4413700.0 1692000.0 1369300.0 1352400.0 False True 2190327.3543062615 1293097.2512885628 1106277.0767958283 1.0 0.5903671196665136 0.5050738532853768 21.062715072548283 -13.999999999999998 0.22056021188008296 3.477989192572563 0.4596944827704742 0.9994984594573945 0.004838040607863315 13.014964411317049 0.1487745090924695 14.051002341350696 0.04702972586604328 1.0000000000000041e-14 13.999999999999998 -3.0182947098020887 YKTQYEELK(ub)AQQDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKTQYEELKAQQDK 14 2 P12270 P12270 TPR Nucleoprotein TPR 1 7810200.0 1002500.0 1340600.0 5467100.0 True False 1297756.0122293292 1265994.4315178888 4472143.897183134 1.0 0.9755257687792336 3.446059085868332 20.307587740770614 -6.904664894600736 0.9313269592192547 0.9100125004720424 3.7313974438559647 0.9887470483836026 0.12293550234579026 0.10805196908381402 0.15869628494557086 0.09806595638259949 0.26166600697184783 1.2454752606441303e-07 6.904664894600736 2.821384943383922 up YKVEGFPTIYFAPSGDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKVEGFPTIYFAPSGDK 17 1 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 46182000.0 14221000.0 14766000.0 17195000.0 False True 18643868.716359887 12562970.357417181 15415826.346086863 1.0 0.6738392416587469 0.8268576967912011 24.152197923280017 -10.059212892076737 4.692542104774942 1.00000960839948 0.7503484692185124 0.780176826524768 0.06246952273939368 15480408.241968736 33184726.336490385 916.4311398310007 0.0213849785462897 8.72543540840165e-11 10.059212892076737 -0.24966113918096766 YKVEGFPTIYFAPSGDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKVEGFPTIYFAPSGDK 17 1 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 51472600.0 18853000.0 9600600.0 23019000.0 False True 18254521.834610462 13434169.646467598 16989633.344802354 1.0 0.7359365404464605 0.9307082102030255 24.12175054301604 -10.291835956191308 5.017661809370316 1.0000466173379836 0.8333223756750046 0.49403760317200396 0.07951520120912518 4.1478687235927486e-05 5.853971612093411e-06 0.0770117731191487 0.025663420837741962 5.106978668119694e-11 10.291835956191308 -0.16672424166297906 YKVEGFPTIYFAPSGDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YKVEGFPTIYFAPSGDK 17 1 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 29037800.0 0.0 23878000.0 5159800.0 False True 0.0 19616784.340334486 4139963.2683793246 0.0 YKVEGFPTIYFAPSGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKVEGFPTIYFAPSGDK 17 1 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 52463000.0 14221000.0 12494000.0 25748000.0 False True 19478888.008074697 11941973.767867044 19666852.69670551 1.0 0.6130726642566386 1.0096496621651552 24.21540798480291 -10.899239354852057 11.319300348065536 1.0136486931911581 0.8113611632114981 0.23176178236648626 0.16190188143344283 0.053095663779491015 0.00047263905744949456 0.14925603047891425 0.052253607542614315 1.2611322889852177e-11 10.899239354852057 -0.20228752997966004 YKVEGFPTIYFAPSGDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YKVEGFPTIYFAPSGDK 17 1 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 32790300.0 18853000.0 6883400.0 7053900.0 False True 15677104.829512585 6846317.757952082 8528837.876451427 1.0 0.43670804223134996 0.5440314375136188 23.902155818450318 -9.960117117178095 5.909755430336622 1.000000364587432 0.4903697398725923 0.9678093692713357 0.043814592651306154 2.1046274378214016e-07 3.701107866267776e-08 0.04242332725704686 0.014141098971534895 1.096182546246844e-10 9.960117117178095 -0.5096306247148397 YKVEGFPTIYFAPSGDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKVEGFPTIYFAPSGDK 17 1 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 18339700.0 0.0 11769000.0 6570700.0 False True 0.0 11114044.804217536 5374900.021075386 0.0 YKVEGFPTIYFAPSGDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKVEGFPTIYFAPSGDKK 18 2 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 45603000.0 12857000.0 14837000.0 17909000.0 False True 16855651.507365126 12623377.434173014 16055948.475258486 1.0 0.7489106801156391 0.952555792236378 24.006729055893164 -9.97201615144368 5.883591664995947 1.000000133575214 0.8507332363817863 0.4173636175891624 0.08313776888476551 1.456686377290139e-07 2.5586217595566323e-08 0.08049786995348845 0.026832599527605933 1.0665564551797645e-10 9.97201615144368 -0.14926689719342767 YKVEGFPTIYFAPSGDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKVEGFPTIYFAPSGDKK 18 2 P13667;A0A499FI48 P13667 PDIA4 Protein disulfide-isomerase A4 0 40406000.0 12857000.0 12677000.0 14872000.0 False True 17610580.34736072 12116888.222766992 11359539.898454396 1.0 0.6880459351007667 0.6450406332098442 24.069939117416055 -13.999999999999998 0.2791919006040322 3.531111817631908 0.6319907326342025 0.9996033896931438 0.0031499709393685844 15.354594512331843 0.16736868990700185 22.18021206038022 0.01707712159981344 1.0000000000000041e-14 13.999999999999998 -2.899121084997706 YKVPDGKPENEFAFNAEFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YKVPDGKPENEFAFNAEFK 19 2 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 14747600.0 3707800.0 5314400.0 5725400.0 False True 4860961.706386275 4521512.235368954 5132990.529914839 1.0 0.9301682482766 1.0559619350983935 22.212810338253338 -6.756028323393734 1.6273323680481855 0.959237209134901 1.0563344074444398 0.6745324721969936 0.029357239575764495 0.28966637644649174 1.5108932354656734 0.014239964081283387 0.034357617159896534 1.7537661227044128e-07 6.756028323393734 0.09709719830953889 YKVPDGKPENEFAFNAEFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YKVPDGKPENEFAFNAEFK 19 2 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 24735900.0 6065300.0 4401600.0 14269000.0 False True 5872760.371477372 6159181.834040775 10531520.839175692 1.0 1.0487711815987735 1.7932829151900753 22.485607341514317 -6.920212368787844 0.8231507604002916 0.983698437863107 1.9139303972600088 0.9942397254404257 0.02755103613534515 0.09804688045731508 0.10496803280914323 0.02376478883787592 0.07133193456868339 1.2016766743873525e-07 6.920212368787844 0.9302319593969018 YKVPDGKPENEFAFNAEFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YKVPDGKPENEFAFNAEFK 19 2 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 86400000.0 20694000.0 41336000.0 24370000.0 False True 31394310.934049413 33959267.840357915 19553258.818249553 1.0 1.081701328361586 0.62282809325949 24.90399981151789 -6.8608875497414035 1.1813402190269269 1.0444313239961338 0.600237747153987 0.9547049364562112 0.042535609387619466 0.1458842079641148 0.38637293341751183 0.02807432215125157 0.06559638370359122 1.3775661108010965e-07 6.8608875497414035 -0.4441935768421468 YKVPDGKPENEFAFNAEFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YKVPDGKPENEFAFNAEFK 19 2 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 16208200.0 3707800.0 6050200.0 6450200.0 False True 5078673.859527416 5782882.1586641045 4926795.606038901 1.0 1.1386598782703123 0.9700948992415419 22.27602039977623 -6.688122840533654 1.8728125783994471 1.0870810043438088 0.970685604862032 0.3618054723391586 0.05866552066109037 0.4206997691855904 2.8593201153813976 0.02507169753723238 0.06544993399454385 2.050582088043514e-07 6.688122840533654 -0.1163953994817768 YKVPDGKPENEFAFNAEFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YKVPDGKPENEFAFNAEFK 19 2 Q15181 Q15181 PPA1 Inorganic pyrophosphatase 0 69331000.0 20694000.0 32229000.0 16408000.0 False True 26788790.93972442 30435427.81843209 13421912.360297224 1.0 1.136125474528235 0.5010271792593002 24.67512613361034 -6.8506371645424915 1.2320117732014746 1.0726819228462492 0.4753242505635093 0.9412301675220617 0.06618657886686635 0.15675478492634867 0.45753825972684437 0.04203092236463107 0.09730247833433145 1.410466694132418e-07 6.8506371645424915 -0.5973576722827398 YLAEFATGNDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLAEFATGNDR 11 0 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 0 61934000.0 20694000.0 19963000.0 21277000.0 False True 27130034.40098104 16984598.215164535 19075460.143395785 1.0 0.6260441090539259 0.7031122726002148 24.693387541174967 -10.098774651902177 5.216769663624651 1.0000066696960528 0.6645781908266326 0.9619140348285545 0.03146294601850247 2.4407402674081494e-06 4.216135249393351e-07 0.03046447231392801 0.010154622162468407 7.965725713029207e-11 10.098774651902177 -0.3354284788694202 YLAEFATGNDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLAEFATGNDR 11 0 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 0 44580200.0 13128000.0 3718200.0 27734000.0 False True 12711258.825903894 5202896.650156847 20469633.397834335 1.0 0.40931403580218345 1.6103545430229051 23.599603575117705 -6.772959380847856 1.5629869362582753 0.6624839275820532 1.6179032853636062 0.7418081401721845 0.24915678224133758 0.26166589508112953 1.2619107353523251 0.12561774081120922 0.29823500484653415 1.68671077447504e-07 6.772959380847856 0.955419357781553 YLAEFATGNDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLAEFATGNDR 11 0 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 0 57083000.0 20694000.0 17981000.0 18408000.0 False True 28345131.03432231 17186539.96478448 14060409.524660349 1.0 0.606331293511178 0.4960432007752937 24.75659760269786 -13.999999999999998 0.17849970792648007 3.0333005553677963 0.4070651995572848 0.999500023788208 0.004836724871588833 12.185675230401788 0.13391826965248535 8.590473960857736 0.0834070062841428 1.0000000000000041e-14 13.999999999999998 -2.6262353558105116 YLAEFATGNDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLAEFATGNDR 11 0 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 0 27051600.0 13128000.0 9320300.0 4603300.0 False True 10916513.66900977 9270089.693965292 5565828.746745603 1.0 0.8491804228928498 0.5098540537301848 23.38000885055198 -6.957678743709775 0.46699891356264245 1.0092289417497415 0.3359648825615836 0.9996741841702411 0.0036998661291627807 0.08054096196660315 0.024275771972291308 0.0046657152680301675 0.02801295028296761 1.1023544415863233e-07 6.957678743709775 -0.673264059188158 YLAEFATGNDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLAEFATGNDR 11 0 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 0 19215900.0 3909300.0 10308000.0 4998600.0 False True 5060665.913823564 9734350.738539755 4088906.08996719 1.0 1.923531587404277 0.8079778747690213 22.27089580550068 -6.686851680796629 1.8773608797578594 1.5806874632259944 0.8119500156971852 0.35583224356968957 0.3908410642865698 0.4234760177180349 2.891171164665332 0.1666915632059686 0.4358457071922807 2.0565928386862667e-07 6.686851680796629 -0.7687374475288092 YLAEFATGNDRK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLAEFATGNDRK 12 1 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 0 27117300.0 8270500.0 10413300.0 8433500.0 False True 10842705.591635931 8859676.230725486 7560882.319844354 1.0 0.8171093603758682 0.6973243214937813 23.37022146302441 -8.973713186871798 0.06055929453418955 1.7537943258078523 1.597257137032226e-12 0.9999950899608974 0.00027572300751552137 0.45778838993736887 0.019045682066261935 0.2983260939096264 0.24563059068392254 1.0623969448727026e-09 8.973713186871798 -1.7537943258062552 YLAEFATGNDRK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLAEFATGNDRK 12 1 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 0 16602800.0 4704400.0 1365700.0 10532700.0 False True 4555061.397058371 1911031.1320314158 7773869.895773057 1.0 0.4195401478595979 1.7066443716419213 22.11903906937448 -6.784093209377693 1.5198294654491977 0.6730770882735811 1.7181980814432625 0.7816395733355654 0.245934603138346 0.24426377946948036 1.1146284352286078 0.12741650759243903 0.29964935367382894 1.6440188418754487e-07 6.784093209377693 1.0451209931696814 YLAEFATGNDRK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLAEFATGNDRK 12 1 P62258;P62258-2;K7EM20 P62258 YWHAE 14-3-3 protein epsilon 0 19573800.0 8270500.0 5745600.0 5557700.0 False True 11328327.351858655 5491740.393841605 4245085.724424423 1.0 0.48477945801421135 0.37473190812480583 23.433431524547302 -13.999999999999998 0.21695534048817564 4.068210210134565 0.31412200249863054 0.9994950313226685 0.0061244755143684375 12.91857764665576 0.14758153881634506 16.954682542825562 0.06214963591402297 1.0000000000000041e-14 13.999999999999998 -3.754088207635935 YLAEVAAGDDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLAEVAAGDDK 11 0 P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 0 6579540.0 1266000.0 2365900.0 2947640.0 False True 1659738.25996144 2012916.9422059704 2642646.4885594337 1.0 1.2127917942029822 1.5922067667590125 20.6625243164213 -6.962226816841004 0.4028233811844735 0.9797816068996469 1.8391342676642912 0.9998440798689906 0.0030584669958811112 0.07891504331912767 0.01826111043953465 0.004880991159208285 0.031755945000612545 1.090870464102636e-07 6.962226816841004 0.8593526607646443 YLAEVAAGDDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLAEVAAGDDK 11 0 P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 0 4680530.0 1266000.0 2022930.0 1391600.0 False True 1734074.412363588 1933550.263665065 1062932.7409016383 1.0 1.1150330400352233 0.6129683555233558 20.725734377944192 -6.846440572683839 1.2521502470013373 1.0612463253491617 0.5942348329100612 0.9349649866900511 0.054767905516787216 0.16141435960586464 0.48880469994867526 0.03425512644878063 0.07910864841242228 1.4241621106044194e-07 6.846440572683839 -0.46701149243910056 YLAEVAAGDDK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLAEVAAGDDKK 12 1 P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 1 118507000.0 46078000.0 41015000.0 31414000.0 True False 44615279.11182196 57392503.39039936 23185731.00020076 1.0 1.2863867386451417 0.5196814064995305 25.41103452960249 -6.805538638851815 1.4331495535839167 1.1569205610888575 0.507587326279484 0.8478735305710277 0.12337795189191804 0.2129466370273837 0.8628077848352427 0.06770760915370898 0.15696564409148528 1.564809093149207e-07 6.805538638851815 -0.6493332348093735 YLAEVAAGDDK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLAEVAAGDDKK 12 1 P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 1 402333000.0 241070000.0 131100000.0 30163000.0 True False 365720814.57771796 107704180.71102487 24201269.829087432 1.0 0.2944983616406581 0.06617416582381726 28.446167497436644 -9.754391222749199 0.3139885821407964 1.405824519762443 6.42492861661458e-20 0.9986331698961394 0.01469500613911242 1.161820254760088 0.1385262880821633 0.5323236915298155 0.07583361528524263 1.7603895313748758e-10 9.754391222749199 -1.405824519762443 YLAEVAAGDDK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLAEVAAGDDKK 12 1 P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 1 125525700.0 46078000.0 72706000.0 6741700.0 True False 38315898.601510614 72314318.34698892 8151358.299901123 1.0 1.8873188672687924 0.2127408881800244 25.191439805036765 -6.762732591492386 1.6020461386639362 1.5136466764783951 0.20575288513292644 0.7020761373072821 0.3733710757159512 0.27835037228246506 1.408573182962256 0.18382766752868762 0.4406075754012407 1.726900870831806e-07 6.762732591492386 -1.3078937913454687 YLAEVAAGDDK(ub)KGIVDQSQQAYQEAFEISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLAEVAAGDDKKGIVDQSQQAYQEAFEISK 30 2 P63104;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 1 25947300.0 8611800.0 9645800.0 7689700.0 True False 11148144.863956666 9109002.750660336 6290253.502984982 1.0 0.8170868661844242 0.5642421747964679 23.41030031890924 -6.966579440016492 0.32982369065830525 1.03086793093241 0.3421860879284468 0.9999420963309 0.0013594865782841214 0.07742902978924976 0.012991905545330884 0.003691724192163628 0.02205681311405036 1.0799920534771584e-07 6.966579440016492 -0.6886818430039632 YLAEVAAGDDKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLAEVAAGDDKK 12 1 P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 0 42049900.0 4139200.0 20691000.0 17219700.0 False True 5426531.284069813 17603983.4528863 15437970.627025994 1.0 3.2440582263968056 2.844905855854158 22.371598870790336 -10.082755534188356 4.767462065283731 0.9999141178030072 3.0444820411541316 0.9722072857968598 0.16295327300739226 56617947.012801565 9.825546228212552 53840.858435279086 0.05578323963853029 8.265030599865254e-11 10.082755534188356 2.0445679233511243 YLAEVAAGDDKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLAEVAAGDDKK 12 1 P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 0 38207400.0 5694900.0 5110500.0 27402000.0 False True 5514118.516730662 7151149.300905439 20224594.157620873 1.0 1.2968798692316423 3.66778372576803 22.394698845316107 -6.930128116388785 0.7457393839260447 0.9641169893069444 4.156110541606952 0.9965633842108298 0.06998363585086281 0.09257129433191841 0.07735451173091268 0.06380717539566212 0.2143748477644052 1.1745510125858198e-07 6.930128116388785 3.1919935523000076 up YLAEVAAGDDKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLAEVAAGDDKK 12 1 P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 0 34110900.0 4139200.0 13587100.0 16384600.0 False True 5669574.097674055 12986776.995468745 12514894.931429286 1.0 2.2906089190714654 2.2073783172819854 22.434808932313228 -10.412966644368359 5.598920939612051 0.9993546328513857 2.2489936181767294 0.9966805746925116 0.033978750894849495 0.0002738510160786084 2.8712587952598323e-05 0.03291448026357545 0.01096659469505458 3.8639665279258814e-11 10.412966644368359 1.2496389853253436 YLAEVAAGDDKK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLAEVAAGDDKK 12 1 P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 0 14560400.0 5694900.0 6295300.0 2570200.0 False True 4735561.676846723 6261385.969380779 3107616.936737896 1.0 1.3222055580004735 0.6562298516629542 22.175104120750383 -6.775126008331552 1.554613078334038 1.1835944776209693 0.6517157527479068 0.7498546518343734 0.1360049942194868 0.2582196755154172 1.2322185937095183 0.06892700567950856 0.16333053406770914 1.678316992346266e-07 6.775126008331552 -0.5318787248730624 YLAEVAAGDDKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLAEVAAGDDKK 12 1 P63104;E7EX29;B0AZS6;P63104-2;H0YB80;B7Z2E6 P63104 YWHAZ 14-3-3 protein zeta/delta 1 68731000.0 24147000.0 31420000.0 13164000.0 True False 33074798.448138632 30031760.507954415 10054934.321090216 1.0 0.9079952688160532 0.3040059136522443 24.979229029218683 -6.933962003193784 0.7135178934861568 1.0079734780010479 0.16649484717250163 0.9972612986700462 0.01615521071776741 0.09063207446004537 0.06797946138464582 0.015081886853012563 0.053510034452765934 1.1642278842763605e-07 6.933962003193784 -0.8414786308285462 down YLAEVACGDDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLAEVACGDDR 11 0 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 15760700.0 1958500.0 7997300.0 5804900.0 False True 2567612.4661409766 6804134.0132312365 5204264.632532697 1.0 2.649984802207161 2.0268886762162 21.291996039943704 -10.296811089009683 5.454142081095542 0.9998044345049266 2.3384367392116854 0.8601811879908109 0.254377928230628 0.0006050261993138014 7.800414633321933e-05 0.24633484701961322 0.08210012330664045 5.04880864717364e-11 10.296811089009683 1.3386323047067588 YLAEVACGDDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLAEVACGDDR 11 0 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 10982200.0 1958500.0 4447700.0 4576000.0 False True 2682610.3764724196 4251185.907422951 3495243.045678279 1.0 1.5847198477675235 1.3029260888323468 21.355206101466596 -10.007028376285726 4.352303716058617 0.9999797040008586 1.4438229681378185 0.7678450082234485 0.11504182068314411 11530426.527483756 4418553.3015484195 2231.2292924001636 0.03938187495545151 9.839468137443939e-11 10.007028376285726 0.44384326413695996 YLAEVACGDDRK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLAEVACGDDRK 12 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 6541370.0 879570.0 3369700.0 2292100.0 False True 1153124.7877679951 2866953.8949877257 2054935.4793757326 1.0 2.4862477377986494 1.7820581962801225 20.137117214969976 -10.097059328044578 4.547636509208997 0.999912289455483 2.1341529670808166 0.7757153608675524 0.28748417662273684 100027783.74756546 16.917757522333847 93013.92266242106 0.09841348026859754 7.997249988150634e-11 10.097059328044578 1.1342406776253335 YLAEVACGDDRK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLAEVACGDDRK 12 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 7142970.0 879570.0 2832800.0 3430600.0 False True 1204770.798485497 2707637.5291831126 2620362.935424806 1.0 2.2474295796236525 2.1749887519840563 20.200327276492867 -10.373479171967489 5.8676860374240505 0.9997447347872422 2.211209165803856 0.9973243689914002 0.02957384404365833 9.877665587481223e-05 1.0546869680376493e-05 0.028640441569654305 0.009544917122034492 4.231758040294031e-11 10.373479171967489 1.2114644310166138 YLAEVATGEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLAEVATGEK 10 0 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 YLAEVATGEK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLAEVATGEKR 11 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 15365700.0 7637100.0 7728600.0 0.0 True False 7394664.440837179 10814670.284116568 0.0 1.0 1.4624964216621297 0.0 22.818053250722343 -6.844722966862551 1.4182830166810136 1.2471913949278135 2.0848122149764968e-22 0.8874032225878692 0.20480731630348406 0.1796941567532224 0.7260383147118684 0.11594995037076779 0.2465778538231799 1.4298057298435002e-07 6.844722966862551 -1.2471913949278135 down YLAEVATGEK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLAEVATGEKR 11 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 35707100.0 18695800.0 2991700.0 14019600.0 True False 28362895.44606171 2457807.760741211 11248619.914991032 1.0 0.08665574237352718 0.39659631846765286 24.757501482841455 -10.43539070472518 5.983407137236162 1.0003173921124258 0.2416260318087221 0.8886746447470419 0.1265327103358125 0.0005359479899133592 5.0573606404307673e-05 0.12256368146066854 0.04083825665675729 3.6695203058314414e-11 10.43539070472518 -0.7586913603037037 YLAEVATGEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLAEVATGEKR 11 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 14059330.0 8562000.0 4869000.0 628330.0 True False 11727602.779349945 4653871.480370154 479931.39486255095 1.0 0.3968305857497772 0.04092323076525221 23.48340480871277 -8.426789651755259 0.44754501891322224 1.0689277127275114 1.718633203880815e-16 0.9955486198856122 0.02641092551061053 0.17240855730788843 0.14064485435293253 0.08003851118231271 0.07469484682428562 3.742918306532753e-09 8.426789651755259 -1.0689277127275112 YLAEVATGEK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLAEVATGEKR 11 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 23724740.0 7637100.0 15099100.0 988540.0 True False 6350587.030895367 15017758.151363295 1195239.1435074615 1.0 2.3647826694292142 0.18820923761735223 22.59845852615662 -6.737186454869122 1.6970049283959323 1.8146696453210753 0.18770017431999764 0.5922579009935972 0.573473227509017 0.32292317854785185 1.8248691016069527 0.26746063075666787 0.6583604059301468 1.8315279269588798e-07 6.737186454869122 -1.6269694710010776 YLAEVATGEK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLAEVATGEKR 11 1 P61981 P61981 YWHAG 14-3-3 protein gamma;14-3-3 protein gamma, N-terminally processed 1 48735900.0 18695800.0 17479800.0 12560300.0 True False 24202081.649313804 16507033.764020883 10274454.279561272 1.0 0.6820501642464669 0.42452770916309096 24.528627804933905 -7.399685848408238 0.18855564912122724 1.209292318482634 8.149887182503662e-15 0.9999738247398585 0.0012041648068142996 0.12037438188167054 0.014320293546397612 0.026459706365040987 0.056574302364621624 3.9839524984384765e-08 7.399685848408238 -1.2092923184826259 down YLAFLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLAFLR 6 0 P40429;M0QYS1 P40429 RPL13A 60S ribosomal protein L13a 0 12474400.0 4984400.0 3591600.0 3898400.0 False True 6534596.6689982675 3055747.27994715 3495030.964093347 1.0 0.4676259966348598 0.534850296220214 22.63966676148975 -10.415702017633953 5.96266637266518 1.0001636512395629 0.5012381464279689 0.9865584236523024 0.027444205383352217 5.972451228720349e-05 5.852566579649561e-06 0.026581321268785648 0.008857579199968137 3.8397060879061575e-11 10.415702017633953 -0.4989255048115939 YLAIAPPIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLAIAPPIIK 10 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 5693900.0 1291700.0 2343500.0 2058700.0 False True 1693431.208840593 1993858.934891451 1845685.4724448419 1.0 1.1774076942024387 1.0899087384296464 20.69151795168014 -10.082783673059389 5.180414728823923 0.9999976317126285 1.1336582163162965 0.7567604804117389 0.03572129911250127 9.771072520797534e-07 1.7301487238503056e-07 0.0345876119190006 0.011528999713840186 8.264495108152438e-11 10.082783673059389 0.13366058460366803 YLAIAPPIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLAIAPPIIK 10 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 5691600.0 2126400.0 1107200.0 2458000.0 False True 2058898.5959325128 1549310.7339717231 1814176.0615806144 1.0 0.7524949198724438 0.8811391028021663 20.973441345992804 -10.253370524491467 5.044415575071782 1.0000313743902574 0.8168170113372132 0.7299862076776027 0.05251876775950102 1.8534353929058295e-05 2.743239653124046e-06 0.05085978133000053 0.016950359407944156 5.579939311707039e-11 10.253370524491467 -0.18321436305304417 YLAIAPPIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLAIAPPIIK 10 0 Q16531;F5GY55 Q16531 DDB1 DNA damage-binding protein 1 0 6835100.0 1291700.0 2524100.0 3019300.0 False True 1769276.3968799727 2412576.9159174967 2306203.524435411 1.0 1.3635952642402007 1.3034727239352097 20.75472801320303 -10.11128061170054 4.651250325080202 0.9999755751271442 1.3335339940929196 0.9762097575311448 0.024544924318522465 17104470.915849302 0.0504849864878666 4491.385692148521 0.008402380447846669 7.739615546344936e-11 10.11128061170054 0.3335584189657754 YLANK(ub)CSIASR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLANKCSIASR 11 1 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 1 8640800.0 2109900.0 2645200.0 3885700.0 True False 2042922.3794008715 3701442.1545357667 2867918.6014986965 1.0 1.8118369018118494 1.403831408582333 20.962202959405694 -10.13270000278666 4.378956340992799 0.9999308114412695 1.6078341545555772 0.7474248483849373 0.16656754598762125 24869792.24604174 28773792.419446245 18712.18292663794 0.05702049866433746 7.367158223027253e-11 10.13270000278666 0.6079033431143077 YLCDK(ub)VVPGNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLCDKVVPGNR 11 1 P33992;B1AHB1;B1AHB2 P33992 MCM5 DNA replication licensing factor MCM5;DNA helicase 1 32890500.0 4033300.0 4030200.0 24827000.0 True False 6118810.973726757 3310979.3219036795 19919932.567939322 1.0 0.5411148237983688 3.255523442948717 22.544819900515265 -6.863395242145834 1.1683805879408844 0.7483841687259108 3.3958041610328946 0.9576399643100896 0.2441609635019507 0.14334965080510423 0.36992432486656424 0.16274280104106756 0.3814839862247318 1.3696347234456612e-07 6.863395242145834 2.647419992306984 up YLCISLAQAHILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLCISLAQAHILK 13 0 Q8N6R0;Q8N6R0-3;Q8N6R0-4;Q8N6R0-2 Q8N6R0 METTL13 Methyltransferase-like protein 13 0 35911500.0 8797500.0 13944000.0 13170000.0 False True 13346450.683400987 11455584.255030736 10566943.727383934 1.0 0.8583243985067937 0.7917418629153643 23.66995279097291 -13.999999985306872 0.1006691166976764 1.6983187125908072 0.6513877833355799 0.9997903570960786 0.0012574029913567895 12.075403395300446 0.09462453982359938 1.7488869977514416 0.1251304326820159 1.0000000338321791e-14 13.999999985306872 -1.0469309292552273 YLCISLAQAHILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLCISLAQAHILK 13 0 Q8N6R0;Q8N6R0-3;Q8N6R0-4;Q8N6R0-2 Q8N6R0 METTL13 Methyltransferase-like protein 13 0 25165200.0 8797500.0 7690500.0 8677200.0 False True 11388537.174650906 7262516.914507176 7098038.635590632 1.0 0.6377041057276783 0.623261664491007 23.44107911306536 YLDEIVK(ub)EVEAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLDEIVKEVEAK 12 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 8318200.0 3187600.0 1791300.0 3339300.0 True False 3086411.3828040226 2506575.431506093 2464637.1531473333 1.0 0.8121326422885515 0.7985446032499388 21.557498938548502 -13.999999999999984 0.37279766603318476 3.6633239825000703 0.7971972635161235 0.9997956473932346 0.0013141699445367522 23.150216998323454 0.19843711510046463 49.33274672427128 0.0037646624605644856 1.0000000000000368e-14 13.999999999999984 -2.8661267189839466 YLDEIVK(ub)EVEAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLDEIVKEVEAK 12 1 P12270;P12270-2 P12270 TPR Nucleoprotein TPR 1 14938300.0 4335800.0 5181400.0 5421100.0 True False 5612778.5713954475 4893050.535183344 4434515.425183281 1.0 0.8717697434422101 0.7900748922793819 22.42028371427324 YLDLILNDFVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLDLILNDFVR 11 0 Q15046;Q15046-2;J3KRL2;H3BPV7 Q15046 KARS Lysine--tRNA ligase 0 23002100.0 8720000.0 8336300.0 5945800.0 False True 11288211.896897515 7872377.576803366 4863725.409059925 1.0 0.6973981042087838 0.43086765676295335 23.42831363909262 -7.151453086556219 0.20101553808177505 1.1683328942898397 2.2008486283124823e-11 0.9999908716140872 0.0007024421019642864 0.08335967836288226 0.008350999665262206 0.01195587842038179 0.033519898754655796 7.05581058349759e-08 7.151453086556219 -1.1683328942678313 down YLDQMEDLYEDFHIVK(ub)LPLLPHEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLDQMEDLYEDFHIVKLPLLPHEVR 25 1 O43681 O43681 ASNA1 ATPase ASNA1 1 19573900.0 5742600.0 4208500.0 9622800.0 True False 7433908.9035692215 3974293.275431181 7871549.138265969 1.0 0.5346168922682136 1.058870809472339 22.825689578592694 -6.672529431184328 1.9287135638235668 0.7035854436418921 1.0567604750601531 0.2901185328882774 0.1975721522904068 0.4553653555448726 3.2681996506374045 0.08240301487576578 0.21941203669397935 2.125546296726512e-07 6.672529431184328 0.353175031418261 YLEK(ub)CIAYAESHDQALVGDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLEKCIAYAESHDQALVGDK 20 1 Q04446;E9PGM4 Q04446 GBE1 1,4-alpha-glucan-branching enzyme 1 11707700.0 1775600.0 3643200.0 6288900.0 True False 2432087.303785773 3482231.377548685 4803591.3439611355 1.0 1.4317871616402353 1.9750900127984274 21.213763586953583 -6.968012799732511 0.3019034018469683 0.9078793152830034 2.5160680239816675 0.9999624683990214 0.0024440555122290293 0.07695293780389172 0.011325919954897588 0.008929555373225892 0.04862904565475438 1.0764334880051138e-07 6.968012799732511 1.6081887086986641 YLEK(ub)SGVLDTLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLEKSGVLDTLTK 13 1 Q99417;A0A087WV05;A0A0D9SEI7 Q99417 MYCBP C-Myc-binding protein 1 14334500.0 4103400.0 6875100.0 3356000.0 True False 5379597.13738213 5849361.878929899 3008753.3130251523 1.0 1.0873234053686722 0.5592897081674967 22.359066706852744 -6.864434652721132 1.1632008060482084 1.0480572104724675 0.5314763790273527 0.9588021026195243 0.046907254386855377 0.14229891282126103 0.3633815755405936 0.03139198019212001 0.07368027740856399 1.3663606533277712e-07 6.864434652721132 -0.5165808314451148 YLEK(ub)SGVLDTLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLEKSGVLDTLTK 13 1 Q99417;A0A087WV05;A0A0D9SEI7 Q99417 MYCBP C-Myc-binding protein 1 29385200.0 9838800.0 11355000.0 8191400.0 True False 9526472.679486841 15889110.715542758 6045826.603267476 1.0 1.6678902307415897 0.6346343296911805 23.18351070268215 -6.732224179812714 1.7154285554856443 1.4009391837070246 0.6350289453465577 0.5694326045592284 0.28071834405679186 0.3320732242197474 1.9154543961220325 0.12963668230718953 0.32083994124301013 1.8525750900888058e-07 6.732224179812714 -0.7659102383604669 YLEK(ub)SGVLDTLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLEKSGVLDTLTK 13 1 Q99417;A0A087WV05;A0A0D9SEI7 Q99417 MYCBP C-Myc-binding protein 1 12825400.0 4103400.0 5300000.0 3422000.0 True False 5620537.870215444 5065828.475243742 2613794.078302245 1.0 0.9013067062653847 0.4650434066378872 22.422276768375635 -6.942586321768432 0.6350475019189091 1.0047635061961577 0.33787014830268125 0.9984834072262817 0.009051916502534174 0.0866063186671945 0.04938365788138767 0.008994715858427935 0.03714163118304351 1.1413364263720634e-07 6.942586321768432 -0.6668933578934765 down YLEK(ub)SGVLDTLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLEKSGVLDTLTK 13 1 Q99417;A0A087WV05;A0A0D9SEI7 Q99417 MYCBP C-Myc-binding protein 1 26587500.0 9838800.0 13672000.0 3076700.0 True False 8181398.132743245 13598346.22232047 3720023.744946491 1.0 1.6621054252203842 0.45469291245690263 22.963915978116425 -6.757807271183522 1.6206042007494956 1.3856346715492511 0.45073558629149174 0.681992080402529 0.2784038793016109 0.28662020652159775 1.4830970234680068 0.13557363114275434 0.3265296921848248 1.7465970762060556e-07 6.757807271183522 -0.9348990852577594 YLELCVDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLELCVDLR 9 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 73176000.0 20666000.0 29636000.0 22874000.0 False True 31351832.886975285 24347224.252875116 18352943.87396965 1.0 0.776580569966927 0.5853866324221876 24.902046452363347 -6.972936612673275 0.1743000041709807 1.1594534215459469 0.19737239338081344 0.9999971588825969 0.0002855356442863527 0.07536079275558287 0.0054621898954776696 0.007747707077860072 0.021841630257641725 1.0642983462489262e-07 6.972936612673275 -0.9620810281651334 YLELCVDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLELCVDLR 9 0 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 45189500.0 20666000.0 7773500.0 16750000.0 False True 26752544.38776196 7340897.891544327 13701671.869513571 1.0 0.2743999892175656 0.512163316913566 24.673172774455796 -10.177284538176778 5.3229771824140935 1.0000253332843099 0.3932816530661142 0.8967162943798822 0.09706647206752864 2.9183270879324222e-05 4.5106947658261775e-06 0.09398812237121405 0.03132806914929514 6.648374297036404e-11 10.177284538176778 -0.6067436802181957 YLELCVDLRK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLELCVDLRK 10 1 Q14152;Q14152-2 Q14152 EIF3A Eukaryotic translation initiation factor 3 subunit A 0 17210100.0 3321700.0 6415200.0 7473200.0 False True 4300006.130495922 6058188.480585983 6113154.281507391 1.0 1.408879033362515 1.4216617595385515 22.03590728598304 -11.688924317051832 0.5460483678643345 2.5926137897629915e-08 1.420565258605512 0.9999253799005234 0.0016916260161872097 5.211994527379256 0.26997347993930326 6.13131750945274 0.002403731817199895 2.0468012943979452e-12 11.688924317051832 1.420565232679374 YLELLGYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLELLGYR 8 0 D6REX3;O94979;O94979-4;O94979-6;O94979-10;O94979-9;O94979-2;O94979-8;O94979-3;D6RHZ5;O94979-7;H7BXG7;H0YAB3;O94979-5;H0Y8V7;H0Y9K1 D6REX3 SEC31A Protein transport protein Sec31A 0 4359900.0 2157300.0 1101300.0 1101300.0 False True 2954912.108840414 1052640.9244879119 841195.6219854644 1.0 0.3562342586565108 0.28467703640619346 21.494683788719932 -13.999999999999998 0.3101640392750283 7.228824831795025 0.26885795506927207 0.9996723568577045 0.0058225105271915295 17.281353736646608 0.17720758582978963 69.47649134744468 0.024780392395515913 1.0000000000000041e-14 13.999999999999998 -6.959966876725753 YLENGK(ub)ETLQR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLENGKETLQR 11 1 O19617;P10321;A0A140T9U8;A0A140T9H5;A2AEA2;A0A140T921;A0A1W2PRU9;P10321-2;A0A140TA05;A0A140T9L3;A0A140T9E1;A0A140T942;A0A0G2JNV5;A0A140T9J8;P30511-2;P30511;P30511-3;O78179;A0A140T912;A0A1W2PRZ0;A0A140T930;A0A140T937;A0A140T9M5;A0A140T9B7;A0A0G2JH66;D0EV57;A0A0G2JPA3;A0A140T8X0;A0A140T9V0;A0A140T9W7;A0A140T9W3;A0A140T9C2;A0A140T939;A0A140T9D9;A0A140T9X6;Q5QT33;A0A140T9J9;A0A1W2PRX1;A0A1W2PR11;A0A140T962;A0A140T9B3;A0A1W2PP77;D9J307;A0A140T953;Q2L6G2;D5H3J5;A0A140TA13;A0A140T9G0;A0A140TA14;A0A140TA11;A0A140T9H3;A0A140T9A9;A0A140T9Y5;A0A140T997;Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913;A0A140T955;A0A140T933;A0A1W2PPQ2;A0A1W2PRT9;A0A140T975;A0A140T941;A0A1W2PQS8;Q9GJ45;A0A1W2PS39;A0A140T9Z6;Q5RJ27;B0UXQ0;Q5SRN5;P04439;P04439-2;A0A1W2PS24;Q5SRN7;Q5SUL5;A0A0G2JIF2;A0A0G2JL56;A0A0G2JI36;A0A1W2PQD0;A0A1W2PSE7;P01893 O19617;O78179;Q5QT33;D9J307;Q53Z42;Q5SRN5;P01893 HLA-C;HLA-F;HLA-B;HLA-A;HLA-H HLA class I histocompatibility antigen, Cw-7 alpha chain;HLA class I histocompatibility antigen, alpha chain F;HLA class I histocompatibility antigen, A-3 alpha chain;Putative HLA class I histocompatibility antigen, alpha chain H 1 380959500.0 2527800.0 72881700.0 305550000.0 True False 3834857.4069339023 59875391.2076789 245157908.57267767 1.0 15.61345960332624 63.928819916328955 21.87074150373193 -6.949247803878225 0.5670434103529135 0.3898750768491125 81.48955698590053 0.9991409102689657 0.7881712106324313 0.08378924683482782 0.037223582994269463 0.8378629099754343 4.022747048018017 1.1239634691945075e-07 6.949247803878225 81.09968190905143 YLENGK(ub)ETLQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLENGKETLQR 11 1 O19617;P10321;A0A140T9U8;A0A140T9H5;A2AEA2;A0A140T921;A0A1W2PRU9;P10321-2;A0A140TA05;A0A140T9L3;A0A140T9E1;A0A140T942;A0A0G2JNV5;A0A140T9J8;P30511-2;P30511;P30511-3;O78179;A0A140T912;A0A1W2PRZ0;A0A140T930;A0A140T937;A0A140T9M5;A0A140T9B7;A0A0G2JH66;D0EV57;A0A0G2JPA3;A0A140T8X0;A0A140T9V0;A0A140T9W7;A0A140T9W3;A0A140T9C2;A0A140T939;A0A140T9D9;A0A140T9X6;Q5QT33;A0A140T9J9;A0A1W2PRX1;A0A1W2PR11;A0A140T962;A0A140T9B3;A0A1W2PP77;D9J307;A0A140T953;Q2L6G2;D5H3J5;A0A140TA13;A0A140T9G0;A0A140TA14;A0A140TA11;A0A140T9H3;A0A140T9A9;A0A140T9Y5;A0A140T997;Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913;A0A140T955;A0A140T933;A0A1W2PPQ2;A0A1W2PRT9;A0A140T975;A0A140T941;A0A1W2PQS8;Q9GJ45;A0A1W2PS39;A0A140T9Z6;Q5RJ27;B0UXQ0;Q5SRN5;P04439;P04439-2;A0A1W2PS24;Q5SRN7;Q5SUL5;A0A0G2JIF2;A0A0G2JL56;A0A0G2JI36;A0A1W2PQD0;A0A1W2PSE7;P01893 O19617;O78179;Q5QT33;D9J307;Q53Z42;Q5SRN5;P01893 HLA-C;HLA-F;HLA-B;HLA-A;HLA-H HLA class I histocompatibility antigen, Cw-7 alpha chain;HLA class I histocompatibility antigen, alpha chain F;HLA class I histocompatibility antigen, A-3 alpha chain;Putative HLA class I histocompatibility antigen, alpha chain H 1 272841500.0 2527800.0 50053700.0 220260000.0 True False 3272286.930387332 47268167.59426153 180174940.05845124 1.0 14.444994769656864 55.06086229336997 21.64186782582438 -6.951294665679379 0.5444464736338176 0.41890183352163207 70.97693971889575 0.9992989961855752 0.6084467027440613 0.08297002937964576 0.033843024985473834 0.6652092004332775 3.3660507575157816 1.1186786105320645e-07 6.951294665679379 70.55803788537412 YLESFLAFTTHPSQFLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLESFLAFTTHPSQFLR 17 0 Q9HAV4;H0Y9I3 Q9HAV4 XPO5 Exportin-5 0 25607800.0 10380000.0 3777800.0 11450000.0 False True 10050492.581724739 5286295.240966747 8450901.507362911 1.0 0.525973746856851 0.8408445097237885 23.260762874849235 -9.957399858149724 5.411709787535658 1.000000721521033 0.6834091282893799 0.5740948955230958 0.12854545066077985 1.1190472543337681e-06 2.1539480884382597e-07 0.12446388208769994 0.04148786580284971 1.1030625543514528e-10 9.957399858149724 -0.316591593231653 YLESFLAFTTHPSQFLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLESFLAFTTHPSQFLR 17 0 Q9HAV4;H0Y9I3 Q9HAV4 XPO5 Exportin-5 0 3812900.0 1104100.0 762300.0 1946500.0 False True 1512315.6071805977 728619.0654110009 1486776.7894258671 1.0 0.48179034981286856 0.9831127724705939 20.52832781827458 -10.81713984066503 10.382920979194227 1.0033789349937068 0.7324515611417313 0.27523631913317115 0.20466402202121856 0.016105398625708964 0.00028364151097552085 0.19936806266491114 0.06605502907133398 1.52356209538308e-11 10.81713984066503 -0.2709273738519755 YLESFLAFTTHPSQFLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLESFLAFTTHPSQFLR 17 0 Q9HAV4;H0Y9I3 Q9HAV4 XPO5 Exportin-5 0 35942400.0 10380000.0 8177400.0 17385000.0 False True 8631429.911968416 8133346.7231131885 21020123.120842095 1.0 0.9422942439508684 2.4353002150542182 23.04116815028351 -6.897909798723773 0.9744007302171346 0.9343163260279429 2.5855234454537204 0.9854970014757793 0.0831690924461696 0.11295977145450564 0.186229900115095 0.06426016017546683 0.16550537277897218 1.2649990555765502e-07 6.897909798723773 1.6512071194257776 up YLESFLAFTTHPSQFLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLESFLAFTTHPSQFLR 17 0 Q9HAV4;H0Y9I3 Q9HAV4 XPO5 Exportin-5 0 40140800.0 18897000.0 11439000.0 9804800.0 False True 24462539.01555873 10802409.594310869 8020427.0057436675 1.0 0.44158987697230817 0.3278656806900745 24.544070816034825 -13.999999999999975 0.2236944076482748 4.425302497887806 0.26914672611960755 0.9995018617179166 0.006555861164313109 13.102787623584687 0.14980255614226873 19.864824512913092 0.06143907282650227 1.0000000000000573e-14 13.999999999999975 -4.156155771768199 YLFALLVGTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLFALLVGTK 10 0 Q9UHP3;Q9UHP3-1;Q9UHP3-3;Q96B65 Q9UHP3 USP25 Ubiquitin carboxyl-terminal hydrolase 25 0 3699300.0 1438900.0 2260400.0 0.0 False True 2182916.49768067 1857013.95941419 0.0 1.0 0.8507031585437423 0.0 21.057825513814084 -7.1773077014054545 0.9123056278083799 0.992033808232627 4.968939974568656e-19 0.9895383669176928 0.04505041427636885 0.09043053915922707 0.14270277369581572 0.037847139177790215 0.06642958726913949 6.648019713421141e-08 7.1773077014054545 -0.992033808232627 down YLFALQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLFALQLK 8 0 O94887-3;O94887-2;O94887 O94887-3 FARP2 FERM, RhoGEF and pleckstrin domain-containing protein 2 0 16043900.0 4847600.0 4231700.0 6964600.0 False True 7354163.607030929 3476520.0725769913 5588043.757307385 1.0 0.47272813855450174 0.7598476259033659 22.810129841653612 -10.09834872341849 5.33775074763016 1.0000059049433967 0.6162878822286559 0.704260705508853 0.11721603987002187 8.236865442182537e-06 1.3915864555725331e-06 0.11349568729366678 0.03783131419360564 7.973541823746437e-11 10.09834872341849 -0.38371802271474076 YLFALQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLFALQLK 8 0 O94887-3;O94887-2;O94887 O94887-3 FARP2 FERM, RhoGEF and pleckstrin domain-containing protein 2 0 12089100.0 4847600.0 3643700.0 3597800.0 False True 6275313.760481695 3440924.891930283 2943037.316545427 1.0 0.5483271471777623 0.4689864808161431 22.581256163746062 -13.999999999999998 0.244650203274543 4.058436457323266 0.4354210903005224 0.9995329270326184 0.005054478288499632 13.792129197449677 0.15652783897428516 20.664448707696454 0.03773702536227821 1.0000000000000041e-14 13.999999999999998 -3.6230153670227434 YLFIFSVANMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLFIFSVANMR 11 0 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 0 3958430.0 1127000.0 1873300.0 958130.0 False True 1477507.9138835252 1593810.942066208 858991.89863194 1.0 1.0787156719025541 0.5813788816698385 20.49473442716518 -6.866403309212012 1.1528658607889661 1.0436885112705374 0.5541655783642023 0.9609645085058817 0.04312485932977724 0.14035484948276658 0.3508986785372962 0.02908808611453513 0.06847306341058816 1.3601809585878698e-07 6.866403309212012 -0.4895229329063351 YLFIFSVANMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLFIFSVANMR 11 0 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 0 10035200.0 4731300.0 3054900.0 2249000.0 False True 4581107.471282684 4274737.501093044 1659919.4314462205 1.0 0.9331231646255489 0.36234020743928375 22.127264977730817 -6.928912501494903 0.7556690303919029 1.0090392723560373 0.24834323091328778 0.9963200816053915 0.01735781017782471 0.09320655855901583 0.08047653006437916 0.015712661462640325 0.051958343137824665 1.1778432529406921e-07 6.928912501494903 -0.7606960414427495 down YLFIFSVANMR ddPTM_RPMI8226_Bortezomib_8h_R1 2 YLFIFSVANMR 11 0 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 0 381690000.0 100251000.0 127010000.0 154429000.0 False True 152088096.32982457 104344073.16634057 123906040.46136473 1.0 0.6860765285670726 0.8146991345901059 27.18033199935409 -10.063372896574904 4.964721950254263 1.0000055869220572 0.7503878318649846 0.8339291123407357 0.05250995902971968 3.247265966396077e-06 6.126372387427498e-07 0.05084368656722945 0.01694751640184793 8.642255535023439e-11 10.063372896574904 -0.24961775505707262 YLFIFSVANMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLFIFSVANMR 11 0 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 0 6129400.0 1127000.0 2243100.0 2759300.0 False True 1543682.3560298292 2143992.4250602336 2107610.1695673224 1.0 1.3888818620524572 1.3653133763787062 20.557944488688072 -10.226408227220013 5.043084600862973 0.9999526688363923 1.3770976192158233 0.9970788980008887 0.009621793986041904 5.121217225541674e-06 7.855818386663533e-07 0.009317428547784643 0.0031054206555843934 5.937337995772753e-11 10.226408227220013 0.37714495037943097 YLFIFSVANMR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLFIFSVANMR 11 0 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 0 12531600.0 4731300.0 2859900.0 4940400.0 False True 3934285.5821287255 2844493.1510542957 5973414.798171315 1.0 0.7230011883161833 1.5182972037681304 21.907670253165094 -6.812602231614926 1.4033988137085591 0.8494972178464227 1.533079162799588 0.866566880715615 0.12040597411030998 0.20326272726858013 0.7884844384923183 0.06745017044438249 0.1558626866049357 1.5395640746481505e-07 6.812602231614926 0.6835819449531652 YLFIFSVANMR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 YLFIFSVANMR 11 0 Q9UKD2 Q9UKD2 MRTO4 mRNA turnover protein 4 homolog 0 307769000.0 100251000.0 95170000.0 112348000.0 False True 129776895.7426459 89873705.83884633 91901816.7878275 1.0 0.6925247003678558 0.7081523738252564 26.95145832144654 -10.359332673967835 8.73205311995836 1.0000007625876517 0.7003385370997153 0.9979643481187364 0.006379970972911271 9.472226869748739e-08 6.946974591641265e-09 0.006177396070987086 0.0020591267772810122 4.371870871283254e-11 10.359332673967835 -0.2996622254879364 YLFLNAIANQLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLFLNAIANQLR 12 0 A5YKK6-2;A5YKK6 A5YKK6-2 CNOT1 CCR4-NOT transcription complex subunit 1 0 2696980.0 1103000.0 390780.0 1203200.0 False True 1067985.868751676 546820.4918907784 888045.824773718 1.0 0.5120109805665631 0.831514583438934 20.026461127195375 -10.15175201797789 5.364586530591735 1.0000092403436736 0.6717627820026408 0.5845835287779413 0.130436799670074 1.441584142918532e-05 2.279328606015404e-06 0.12629844158532022 0.04209829607117701 7.050955634045309e-11 10.15175201797789 -0.3282464583410327 YLFLNAIANQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLFLNAIANQLR 12 0 A5YKK6-2;A5YKK6 A5YKK6-2 CNOT1 CCR4-NOT transcription complex subunit 1 0 3778600.0 1103000.0 1102700.0 1572900.0 False True 917193.371185084 1096759.5362311886 1901786.117732096 1.0 1.195777870498662 2.0734843681598383 19.80686640262965 -6.9422660668168374 0.6381431169295274 0.9904027629751844 2.3268269452253856 0.9984458002590586 0.018402561802504023 0.0867480623096203 0.05001667863071683 0.018237414396321653 0.07482084663065078 1.1421783745424475e-07 6.9422660668168374 1.3364241822502012 up YLFTGLK(ub)LR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLFTGLKLR 9 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 22592900.0 2405200.0 6880700.0 13307000.0 True False 3648864.243673321 5652785.325845522 10676865.617334716 1.0 1.5491903640007305 2.9260791589731188 21.79901604564459 -6.955400664191169 0.4960253458814334 0.9714493660305242 3.5628065741073423 0.9995597688315475 0.01699849439589448 0.08138689056054052 0.02752804571341175 0.020087078599146543 0.11356862099386968 1.108152003057519e-07 6.955400664191169 2.591357208076818 YLFTGLK(ub)LR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLFTGLKLR 9 1 P54578-2;P54578;A6NJA2;P54578-3 P54578-2 USP14 Ubiquitin carboxyl-terminal hydrolase 14;Ubiquitin carboxyl-terminal hydrolase 1 14698300.0 2405200.0 6468000.0 5825100.0 True False 3113578.8135800343 6108050.114171042 4764991.570573345 1.0 1.9617457851172635 1.5303905428025746 21.570142367737038 -10.205272140532657 4.896770552480007 0.9999042412366634 1.7460681639613205 0.7995448425973615 0.17610004026243936 0.00018412153227951916 2.9882397484827692e-05 0.17052981083394578 0.05683604359954979 6.233441089923869e-11 10.205272140532657 0.746163922724657 YLFTLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLFTLIR 7 0 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 0 8445500.0 2335800.0 2616800.0 3492900.0 False True 3062256.41991938 2226383.6402065097 3131488.214262681 1.0 0.727040239257666 1.0226080983594195 21.546163662174038 -11.808682500328333 24.150255229158436 0.9085754039930346 0.8873417521903099 0.0 0.13745961862062803 0.0 0.0 0.0 0.040000505563189306 1.5535223284946486e-12 11.808682500328333 -0.02123365180272474 YLFTLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLFTLIR 7 0 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 0 6176700.0 2267500.0 1125000.0 2784200.0 False True 2195519.45366675 1574218.3667974968 2054934.4957903817 1.0 0.7170140825527123 0.9359673367313706 21.066130887019877 -10.578082705559567 5.567451324398498 1.0007768170226339 0.8264907096420413 0.4557232444935354 0.08938729170993723 0.0008656650974971974 6.560247569959616e-05 0.08692778639111591 0.028849624346264213 2.6419055939244872e-11 10.578082705559567 -0.17428610738059258 YLFTLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLFTLIR 7 0 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 0 7865600.0 2335800.0 2410700.0 3119100.0 False True 3199408.3826215426 2304187.302881152 2382432.8198809247 1.0 0.720191681498671 0.744647927042311 21.60937372369693 -9.97521199990618 5.042108286825994 1.000001736784885 0.7324198042680753 0.9937738352846394 0.009984220446473574 2.0440093509313096e-07 4.1555391338452534e-08 0.009667245628992096 0.0032223932911010244 1.0587367789599608e-10 9.97521199990618 -0.26758193251680973 YLFTLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLFTLIR 7 0 P57740-2;P57740;P57740-3 P57740-2 NUP107 Nuclear pore complex protein Nup107 0 5302800.0 2267500.0 1101900.0 1933400.0 False True 1885526.7172821192 1095963.8459899737 2337665.0009684274 1.0 0.5812507645448504 1.239794153825643 20.846536162454154 -6.734943678394086 1.7056271878247495 0.7493917862069249 1.2397390135101205 0.5818644340460981 0.17597365597354522 0.3270366018964155 1.8660870222948658 0.08169526178304277 0.20156388911760523 1.841010738000115e-07 6.734943678394086 0.4903472273031956 YLGDGPK(ub)LVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLGDGPKLVR 10 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 5463060.0 1439400.0 999360.0 3024300.0 True False 1393707.0348877257 1398409.6595935533 2232145.102944776 1.0 1.0033741845223636 1.6015884594602718 20.41049589973122 -6.908137936468162 0.9083250048256394 0.9803695353116127 1.675894938923082 0.990199548597994 0.0279963734193639 0.10566239148049528 0.14554330393427742 0.02271199670053653 0.061915032176156674 1.235554945949727e-07 6.908137936468162 0.6955254036114692 YLGDGPK(ub)LVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLGDGPKLVR 10 1 P62191;P62191-2 P62191 PSMC1 26S protease regulatory subunit 4 1 3701270.0 1439400.0 1318200.0 943670.0 True False 1196924.8762319211 1311098.5949577864 1140987.0339629028 1.0 1.0953892102947174 0.9532653691306692 20.190901175165497 -6.725859158009634 1.7380813449581887 1.0576691315694642 0.9534087635965305 0.5399816212759116 0.04011440390262056 0.3441044460226936 2.0344658884078397 0.01830338254585066 0.04563737256349536 1.8799263793367999e-07 6.725859158009634 -0.1042603679729337 YLGQPEMGDK(ub)NR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLGQPEMGDKNR 12 1 Q9BUE0 Q9BUE0 MED18 Mediator of RNA polymerase II transcription subunit 18 1 7460500.0 3747000.0 1339400.0 2374100.0 True False 4850565.364412275 1264861.2125727744 1942038.1603231153 1.0 0.2607657288473697 0.4003735677023342 22.209721481757448 -9.904417794210572 6.691149546134297 1.0000000312608601 0.3305696483099393 0.968411428696108 0.056994661547943144 2.6651155991504476e-08 4.301374708688713e-09 0.0551848462163977 0.018394947916485365 1.2461840999331398e-10 9.904417794210572 -0.6694303829509208 YLIANATNPESK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLIANATNPESK 12 0 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 29740100.0 1621100.0 16176000.0 11943000.0 False True 2125277.798754731 13762603.85355413 10707252.925345486 1.0 6.475672903381423 5.038048640803198 21.01922000007636 -9.660023424117552 7.169556450332557 0.9999999976479406 5.756860772092986 0.9358885907797185 0.5869076475293679 1.0519100024366303e-08 1.984320631447493e-17 0.5682708861596684 0.18942362871988952 2.1876436279684772e-10 9.660023424117552 4.756860774445045 YLIANATNPESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLIANATNPESK 12 0 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 20851800.0 8324300.0 1781500.0 10746000.0 False True 8060049.652991443 2492862.2403997695 7931300.226910216 1.0 0.309286213823082 0.9840262242015541 22.942357295658542 -10.825704773192063 10.760332732972458 1.004706768277006 0.646656219079218 0.2677457628382989 0.27546145574458036 0.031095288050202768 0.0005036787695721917 0.2666425955991755 0.08890480255173423 1.4938095335921948e-11 10.825704773192063 -0.3580505491977879 YLIANATNPESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLIANATNPESK 12 0 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 31589100.0 1621100.0 12551000.0 17417000.0 False True 2220464.478580262 11996455.31939326 13303463.314374695 1.0 5.40267832929426 5.991297515770559 21.08243006159925 -9.712060720758624 0.5362303551488556 4.9332803578478805e-18 5.959865374847993 0.9989431989118521 0.07240232981387923 0.9998825731873796 0.24106854229114458 1.9870730187246384 0.11162657062887656 1.9406145321590748e-10 9.712060720758624 5.959865374847993 YLIANATNPESK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLIANATNPESK 12 0 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 0 11120300.0 8324300.0 1091900.0 1704100.0 False True 6922024.279017209 1086017.7179748188 2060419.4311318388 1.0 0.15689308130092428 0.29766139904732863 22.72276257109282 -10.579483431066635 6.975079678612216 1.0009013368533322 0.2272772420992414 0.9757145321724818 0.057468425071443466 0.0008062736297384611 4.860895347186222e-05 0.05569675846033066 0.018547854436205793 2.6333984095397584e-11 10.579483431066635 -0.7736240947540908 YLIANATNPESK(ub)VFYLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLIANATNPESKVFYLK 17 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 21999800.0 7044500.0 6964700.0 7990600.0 True False 10687021.521934438 5721794.869550531 6411254.407595604 1.0 0.5353965890128422 0.5999103112534122 23.34935649348398 -10.467637067708061 6.0969777413278665 1.0002454861807049 0.5676534501332339 0.9835748663674851 0.026337616816173404 8.793489096833935e-05 7.678117117196587e-06 0.02551546249832331 0.008500429275652642 3.406927817606847e-11 10.467637067708061 -0.432592036047471 YLIANATNPESK(ub)VFYLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLIANATNPESKVFYLK 17 1 P27348;E9PG15 P27348 YWHAQ 14-3-3 protein theta 1 18807400.0 7044500.0 6738400.0 5024500.0 True False 9119244.117854878 6363402.11647034 4110092.555723633 1.0 0.6977992950107803 0.450705398671842 23.12048281557643 -7.267335914874971 0.17917926020324776 1.214269572347049 4.809490264757053e-15 0.9999889846220117 0.0007454931726581987 0.10230169240867511 0.009942281874553208 0.019054512778060972 0.04363683496301561 5.403362260164064e-08 7.267335914874971 -1.214269572347044 down YLILKDPNK(ub)QVIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLILKDPNKQVIR 13 2 O15371-2;O15371-3;O15371;A0A0D9SGB5 O15371-2 EIF3D Eukaryotic translation initiation factor 3 subunit D 1 12636000.0 1441200.0 3248100.0 7946700.0 True False 1865661.8102991623 3067340.3796906276 6500482.140027662 1.0 1.6441031074108623 3.4842767880773082 20.83125606096776 -6.952544346205999 0.5301847662857155 0.9710160720568268 4.240925529069125 0.9993860732832487 0.02608220061905693 0.08248003810191823 0.03185762746757454 0.029090647069692544 0.15217592494400525 1.1154642444631147e-07 6.952544346205999 3.2699094570122984 YLIPNATQPESK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLIPNATQPESK 12 0 P31946;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 0 26265600.0 10901000.0 2396600.0 12968000.0 False True 10554953.721905723 3353574.878103897 9571291.768339075 1.0 0.317725209078264 0.9068056592682961 23.331416917427777 -10.471157810905197 8.721919695841123 1.0000094627074627 0.6122654341733457 0.3661425244214146 0.24049108673576342 4.425265546141942e-05 2.6830662761976846e-06 0.2328601686479512 0.07761816448657795 3.3794201487580115e-11 10.471157810905197 -0.38774402853411705 YLISVLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLISVLK 7 0 Q5VUC0 Q5VUC0 OLAH 0 20922800.0 6567600.0 5556800.0 8798400.0 False True 8610187.200728873 4727747.100236748 7888025.968212309 1.0 0.5490876086685471 0.9161271159754307 23.03761317403424 -9.95531300766112 6.824094238839924 1.0000000198658412 0.7326073623219878 0.4143962682011447 0.14984325139073873 4.5278720448420475e-08 6.969805665801754e-09 0.1450851151041423 0.04836170143149115 1.1083756912850689e-10 9.95531300766112 -0.26739265754385344 YLISVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLISVLK 7 0 Q5VUC0 Q5VUC0 OLAH 0 22382400.0 7644500.0 3810900.0 10927000.0 False True 7401829.531887736 5332612.243580965 8064890.897026601 1.0 0.7204451575934842 1.0895807397728274 22.819450479302734 -6.704175633945814 1.81596607301094 0.8271231048874096 1.0885735013063282 0.4374250960085516 0.11791583781163259 0.38689672829383887 2.48327957806417 0.05174618019371634 0.13239648359322104 1.9761702913013432e-07 6.704175633945814 0.26145039641891865 YLISVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLISVLK 7 0 Q5VUC0 Q5VUC0 OLAH 0 21090200.0 6567600.0 6500700.0 8021900.0 False True 8995819.202716509 6213477.579059816 6127292.436216471 1.0 0.6907072540078956 0.6811266765306025 23.100823235557133 YLISVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLISVLK 7 0 Q5VUC0 Q5VUC0 OLAH 0 13951000.0 7644500.0 2891800.0 3414700.0 False True 6356740.458770953 2876221.2994226427 4128697.982211074 1.0 0.4524679461238767 0.6494992219659286 22.59985575473701 -10.07099326824511 5.073789896088596 1.0000086831489319 0.5509835840432661 0.8738101937389181 0.08043768153612542 7.90097326774893e-06 1.446805467897781e-06 0.077884955834963 0.025961150082262612 8.491936378080234e-11 10.07099326824511 -0.4490250991056658 YLK(ub)ALGIHQTGQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLKALGIHQTGQK 13 1 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 1 3480230.0 782230.0 1053500.0 1644500.0 True False 757398.5368210542 1474168.0439299222 1213756.1160574944 1.0 1.946357132028913 1.6025329559677524 19.53069310859412 -10.227536545341898 4.6777519931684335 0.9998503295830237 1.774445043980913 0.8712116540904553 0.14036563391001317 0.00027617210586009395 4.560600661502665e-05 0.13594096767183253 0.04530281326983585 5.92193252451845e-11 10.227536545341898 0.7745947143978893 YLK(ub)ALGIHQTGQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLKALGIHQTGQK 13 1 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 1 2773800.0 807260.0 654340.0 1312200.0 True False 1105725.837381224 625429.0951869803 1002285.3856073085 1.0 0.5656276393687539 0.906450181159824 20.076562285744636 -9.844140971980563 6.328313952349689 1.0000000127909001 0.7360389102642249 0.4443716453492731 0.13914022003798313 2.508336288236916e-08 4.758408469964376e-09 0.13472194477111973 0.044907312916194785 1.431723086551869e-10 9.844140971980563 -0.26396110252667526 YLK(ub)ALGIHQTGQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLKALGIHQTGQK 13 1 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 1 4240830.0 782230.0 1922900.0 1535700.0 True False 650458.9036646488 1912540.956034234 1856807.7697254645 1.0 2.9402948368591564 2.8546119658971754 19.311098384028398 -10.120387847173813 4.5150189514110926 0.9997986135924979 2.8974534014208397 0.9984729847262639 0.034979885806441666 2703603.7827326963 3030068.143546131 4451.850133668857 0.01197454526216775 7.579004288836706e-11 10.120387847173813 1.8976547878283418 YLK(ub)ALGIHQTGQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLKALGIHQTGQK 13 1 Q2TAL8 Q2TAL8 QRICH1 Glutamine-rich protein 1 1 17274300.0 1813600.0 2187700.0 13273000.0 True False 2347740.9514006134 2065952.5718571437 10857450.192480795 1.0 0.8799746712364664 4.6246372224343855 21.162841800281758 -6.899495993098255 0.9644638001884411 0.842150252839973 5.013683131721083 0.9863134501275164 0.20328704554796787 0.1117767078369976 0.17952619901440925 0.15823537250571318 0.4106634571173963 1.2603872664663972e-07 6.899495993098255 4.17153287888111 up YLK(ub)DVTLQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLKDVTLQK 9 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3QLC8;J3KRB3;A0A087WWH0;J3QS96;A0A0A0MRF8;P18621-2;A0A087WY81;J3KSJ0 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 4266700.0 1159600.0 1722900.0 1384200.0 True False 964258.7789902282 1713618.395731125 1673629.8201823193 1.0 1.7771353842644049 1.7356645919624858 19.8790608502123 -10.179987900065457 4.535237581808011 0.999855776965623 1.7563999881250119 0.9977506089844925 0.016930380102166576 1967124.5365601464 4415498.1452825405 1763.3728109345177 0.005795719670679928 6.607118559293485e-11 10.179987900065457 0.7565442111593889 YLK(ub)YLTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLKYLTK 7 1 P35268;K7ERI7;K7EMH1;K7ELC4;C9JYQ9;H0Y8C2;Q6P5R6 P35268 RPL22;RPL22L1 60S ribosomal protein L22;60S ribosomal protein L22-like 1 1 12148300.0 5118900.0 4504900.0 2524500.0 True False 6710927.471498108 3832786.479962663 2263288.9567139437 1.0 0.5711261962285898 0.33725427168246547 22.67808073456702 -9.561165741929878 0.15774460858518743 1.5924029749326 2.3822442978225244e-20 0.9997446557688061 0.004385424390076265 1.0077973237002191 0.06348394159936677 0.44659386003804835 0.18018378078341274 2.746845660883586e-10 9.561165741929878 -1.5924029749326 YLK(ub)YLTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLKYLTK 7 1 P35268;K7ERI7;K7EMH1;K7ELC4;C9JYQ9;H0Y8C2;Q6P5R6 P35268 RPL22;RPL22L1 60S ribosomal protein L22;60S ribosomal protein L22-like 1 1 18003900.0 5552500.0 8109400.0 4342000.0 True False 5376238.926784836 11347525.709962323 3204699.9427921185 1.0 2.1106810661684094 0.5960858485708396 22.358165824038334 -6.710173474983798 1.7946659033159014 1.682713443437092 0.5996442092998807 0.4658503783614961 0.46802384237139766 0.3747485865624394 2.3529667728769765 0.20752614538218866 0.5270873936187027 1.9490659075845517e-07 6.710173474983798 -1.0830692341372115 YLK(ub)YLTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLKYLTK 7 1 P35268;K7ERI7;K7EMH1;K7ELC4;C9JYQ9;H0Y8C2;Q6P5R6 P35268 RPL22;RPL22L1 60S ribosomal protein L22;60S ribosomal protein L22-like 1 1 11603700.0 5118900.0 4051200.0 2433600.0 True False 7011495.663071059 3872204.58847311 1858833.8015652662 1.0 0.5522651335103402 0.265112308541469 22.74129079608991 -8.406133444122492 0.22996791362074814 1.2524862360379851 9.969401924381032e-14 0.9995540331743842 0.006385947193749398 0.12490813208562483 0.0562383377515076 0.12521961680424157 0.11379075259823739 3.925243073187192e-09 8.406133444122492 -1.2524862360378854 down YLK(ub)YLTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLKYLTK 7 1 P35268;K7ERI7;K7EMH1;K7ELC4;C9JYQ9;H0Y8C2;Q6P5R6 P35268 RPL22;RPL22L1 60S ribosomal protein L22;60S ribosomal protein L22-like 1 1 20130200.0 5552500.0 12814000.0 1763700.0 True False 4617149.767457092 12744968.438620148 2132481.5155725703 1.0 2.760354131990714 0.4618610231365833 22.13857109947261 -6.702045043533561 1.823383573009496 2.090904339688439 0.46838884048197565 0.42735817479894667 0.7427927609568675 0.3912937031507572 2.5305739863927323 0.3248039696209534 0.8332677033378468 1.9858889370889758e-07 6.702045043533561 -1.6225154992064632 YLK(ub)YLTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLKYLTK 7 1 P35268;K7ERI7;K7EMH1;K7ELC4;C9JYQ9;H0Y8C2;Q6P5R6 P35268 RPL22;RPL22L1 60S ribosomal protein L22;60S ribosomal protein L22-like 1 1 18410800.0 5435000.0 9483100.0 3492700.0 True False 7035714.639866738 8955357.148685142 2857064.438128358 1.0 1.2728425763519546 0.40608020426798797 22.746265539343003 -6.822080255395956 1.3627766897674252 1.1467623310896995 0.38628957876270553 0.8891097903412025 0.12049885451856014 0.19079675590872974 0.6956732473563029 0.06947216299860556 0.16004601128452892 1.5063286786402987e-07 6.822080255395956 -0.760472752326994 down YLLDHFLSMGINK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLLDHFLSMGINK 13 0 A0A1B0GV47;Q7Z4S6-6;Q7Z4S6-3;Q7Z4S6-5;Q7Z4S6-2;Q7Z4S6;Q7Z4S6-4;H0YHG9;H0YIM6;H0YI78;H0YHT2 A0A1B0GV47 KIF21A Kinesin-like protein KIF21A 0 14082900.0 4995800.0 2235100.0 6852000.0 False True 4837211.063562666 3127587.085892521 5057255.644406173 1.0 0.6465682486860547 1.0454899688998565 22.205744058051074 -6.6729099899663575 1.9268598831970436 0.7749678401847931 1.0439039406693993 0.2919641010658457 0.15003131587572466 0.45454579588711563 3.256257044489449 0.06261937467247555 0.16668304551210925 2.123684562253516e-07 6.6729099899663575 0.26893610048460614 YLLETSGNLDGLEYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLLETSGNLDGLEYK 15 0 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 14118000.0 3532700.0 5770600.0 4814700.0 False True 4631403.910715459 4909648.973622617 4316521.029863591 1.0 1.0600779090468435 0.9320113540252151 22.14301815114996 -6.77915142057804 1.5392918006237457 1.0340552343562863 0.931025803045511 0.7643357648861726 0.025397030415377594 0.25189617345500104 1.178851889633914 0.012996176643489229 0.030685873961501624 1.6628327880614435e-07 6.77915142057804 -0.10302943131077535 YLLETSGNLDGLEYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLLETSGNLDGLEYK 15 0 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 27502300.0 9453500.0 4491800.0 13557000.0 False True 9153403.817084286 6285399.164427551 10006014.99871783 1.0 0.6866734266324213 1.0931468990849278 23.125876898170564 -6.700835426455697 1.827887337474264 0.8055954059170987 1.0919566619943026 0.4215305290051793 0.13223905906749364 0.39379508698763943 2.558559883097543 0.05770286959626406 0.14824387769964115 1.9914278368264895e-07 6.700835426455697 0.286361256077204 YLLETSGNLDGLEYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLLETSGNLDGLEYK 15 0 P43490;A0A0C4DFS8 P43490 NAMPT Nicotinamide phosphoribosyltransferase 0 23626700.0 9453500.0 8013300.0 6159900.0 False True 7861004.111059102 7970130.762384485 7447906.609840389 1.0 1.0138820244568834 0.947449779267059 22.90628217360484 -6.852158304862667 1.2245715250782527 1.0074242487919396 0.9446806022006405 0.9433916942056203 0.006807351007270844 0.15510236854567988 0.4464835603722103 0.004347237094856858 0.010074991376286618 1.4055350985585797e-07 6.852158304862667 -0.06274364659129905 YLLGTSLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLLGTSLAR 9 0 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 0 92477000.0 33593000.0 29652000.0 29232000.0 False True 44040748.315074734 25228037.18259075 26207353.05314402 1.0 0.5728339809783711 0.595070566595561 25.392335646766757 -10.239795291133104 5.477710510010056 1.0000285076769901 0.5839522737869447 0.9978621271150792 0.009078048064062514 3.1607101070657755e-06 4.3863703601195726e-07 0.008790383346697555 0.0029299274140021383 5.757112404030226e-11 10.239795291133104 -0.41607623389004544 YLLGTSLAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLLGTSLAR 9 0 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 0 46540800.0 18247000.0 5362800.0 22931000.0 False True 17667758.972902842 7504194.006632555 16924683.184745766 1.0 0.42473943742054593 0.9579417067384304 24.074615720302553 -10.619631925778833 9.548419242014567 1.000072038673621 0.6913405720794887 0.30881980152632194 0.2176789149204786 0.00033389953578363466 1.3301294741270553e-05 0.21081536326413666 0.07025556769229292 2.400866844984864e-11 10.619631925778833 -0.3087314665941323 YLLGTSLAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLLGTSLAR 9 0 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 0 51767800.0 13870000.0 31501000.0 6396800.0 False True 21041804.03282428 25879400.431563623 5132469.676182962 1.0 1.2299040705441846 0.2439177585808012 24.326755064546848 -6.845292131422614 1.2576227555531345 1.1223536479992626 0.2079458932241102 0.9331662909330294 0.10888954487306521 0.16271246665728537 0.4976054917861 0.0678266671188892 0.1565515294319204 1.4279331255238917e-07 6.845292131422614 -0.9144077547751525 down YLLGTSLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLLGTSLAR 9 0 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 0 75382000.0 33593000.0 17880000.0 23909000.0 False True 46013239.91669035 17090002.478746828 18262186.62131163 1.0 0.37141489079424256 0.3968898224592831 25.455545708289648 -10.426283718042106 5.983916405900379 1.0002271972194345 0.38415235662677266 0.9987183073440368 0.010400097301937309 3.15343429616497e-05 3.0233769486714163e-06 0.010073466440071203 0.003356616970778211 3.747281180306162e-11 10.426283718042106 -0.6160748405926619 YLLGTSLAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLLGTSLAR 9 0 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 0 41101200.0 18247000.0 13653000.0 9201200.0 False True 15173188.979160681 13579448.579091677 11125128.378457982 1.0 0.8949633855969306 0.7332096366648811 23.85502099573683 -6.964816752923318 0.3611890426537405 1.0137503576416569 0.6088693469378077 0.9999093085266609 0.0010450041748618585 0.07802327164185605 0.015079930324913107 0.0021650200242795525 0.013806038554370322 1.0843843647992373e-07 6.964816752923318 -0.4048810107038492 YLLGTSLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLLGTSLAR 9 0 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 0 38288300.0 13870000.0 16253000.0 8165300.0 False True 17954988.41857437 15348506.262464762 6679299.183053075 1.0 0.854832423427619 0.37200242224291075 24.097881386639298 -6.949111302992942 0.5685159114154156 1.0060553837331476 0.1973643523881811 0.9991296883472404 0.007919497064063549 0.08384456758801288 0.03745437975050989 0.008404493785938178 0.04021470936552939 1.1243167919470078e-07 6.949111302992942 -0.8086910313449666 down YLLGTSLARPCIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLLGTSLARPCIAR 14 1 P00966;Q5T6L6;Q5T6L5 P00966 ASS1 Argininosuccinate synthase 0 18863600.0 6556600.0 4402600.0 7904400.0 False True 8595766.094204726 3745749.2412003838 7086528.512358777 1.0 0.4357667717047084 0.8244208177251964 23.035194794374398 -10.083981797993907 6.046719125284048 1.0000010695148907 0.6300937947149577 0.5470607404546928 0.1586673498697656 2.287678745567178e-06 3.467939457708473e-07 0.15362944498872885 0.05120966696936676 8.241726567398216e-11 10.083981797993907 -0.3699072747999329 YLLLHLLGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLLLHLLGR 9 0 Q9UKI8-3;Q9UKI8-4;Q9UKI8-5;Q9UKI8;Q9UKI8-2;J3KRK0;J3QLK5;Q86UE8-3;Q86UE8-2;Q86UE8 Q9UKI8-3 TLK1;TLK2 Serine/threonine-protein kinase tousled-like 1;Serine/threonine-protein kinase tousled-like 2 0 3197050.0 961080.0 1871100.0 364870.0 False True 1259985.1871119596 1591939.1734906759 327116.75248018117 1.0 1.2634586420334 0.2596195223770629 20.264975342251162 -6.836945463003308 1.2964310304161757 1.140253802531103 0.22853107358718436 0.9190991543214563 0.1208697412108869 0.1723844803215893 0.5641110865057054 0.0731409363081235 0.16839661206622392 1.455641862897805e-07 6.836945463003308 -0.9117227289439187 down YLLLHLLGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLLLHLLGR 9 0 Q9UKI8-3;Q9UKI8-4;Q9UKI8-5;Q9UKI8;Q9UKI8-2;J3KRK0;J3QLK5;Q86UE8-3;Q86UE8-2;Q86UE8 Q9UKI8-3 TLK1;TLK2 Serine/threonine-protein kinase tousled-like 1;Serine/threonine-protein kinase tousled-like 2 0 24203300.0 13820400.0 6562600.0 3820300.0 False True 13381678.96690447 9183080.403506884 2819648.823456641 1.0 0.6862427671608662 0.21070964491303282 23.67375580300589 -7.270899146287239 0.433159947381421 1.0227081768969706 1.6059711592717032e-21 0.9993430757411376 0.008316458341686747 0.09760760343180674 0.03459606864904378 0.011463848632532716 0.051128114100571685 5.359210969416404e-08 7.270899146287239 -1.0227081768969706 down YLLLHLLGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLLLHLLGR 9 0 Q9UKI8-3;Q9UKI8-4;Q9UKI8-5;Q9UKI8;Q9UKI8-2;J3KRK0;J3QLK5;Q86UE8-3;Q86UE8-2;Q86UE8 Q9UKI8-3 TLK1;TLK2 Serine/threonine-protein kinase tousled-like 1;Serine/threonine-protein kinase tousled-like 2 0 50981100.0 13617800.0 25023300.0 12340000.0 False True 20659198.194534604 20557696.60706474 9900993.591185857 1.0 0.9950868573642555 0.4792535265867756 24.300280926971336 -6.908984458789604 0.9026227959845544 1.01648871618503 0.4140187628288732 0.990532653819671 0.023773615869469713 0.10509341239964944 0.1424383246682597 0.019366568038249217 0.05309171153625703 1.2331489606248277e-07 6.908984458789604 -0.6024699533561568 down YLLLHLLGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLLLHLLGR 9 0 Q9UKI8-3;Q9UKI8-4;Q9UKI8-5;Q9UKI8;Q9UKI8-2;J3KRK0;J3QLK5;Q86UE8-3;Q86UE8-2;Q86UE8 Q9UKI8-3 TLK1;TLK2 Serine/threonine-protein kinase tousled-like 1;Serine/threonine-protein kinase tousled-like 2 0 39345680.0 961080.0 9580400.0 28804200.0 False True 1316417.2482104246 9157106.249853803 22001241.201120254 1.0 6.95608194309383 16.712969410746762 20.328185403774054 -6.96375190487305 0.3788626225659028 0.3211662264104743 23.692291687348416 0.9998850606272657 0.06944027297197591 0.07838708385344548 0.016369235672551448 0.12712903903991166 0.8249004988932367 1.08704643257678e-07 6.96375190487305 23.37112546093794 YLLLHLLGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLLLHLLGR 9 0 Q9UKI8-3;Q9UKI8-4;Q9UKI8-5;Q9UKI8;Q9UKI8-2;J3KRK0;J3QLK5;Q86UE8-3;Q86UE8-2;Q86UE8 Q9UKI8-3 TLK1;TLK2 Serine/threonine-protein kinase tousled-like 1;Serine/threonine-protein kinase tousled-like 2 0 21742600.0 13820400.0 3530100.0 4392100.0 False True 11492274.947530651 3511082.650630008 5310467.803224073 1.0 0.3055167637965741 0.4620902151636334 23.454161078440166 -10.254642604371336 8.31061013274234 1.0000003938623907 0.3838034894865674 0.9538127433051636 0.06392084385262875 4.664473825819052e-07 4.18366831512945e-08 0.06189113058236902 0.02063036364306299 5.563619179857455e-11 10.254642604371336 -0.6161969043758233 YLLLHLLGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLLLHLLGR 9 0 Q9UKI8-3;Q9UKI8-4;Q9UKI8-5;Q9UKI8;Q9UKI8-2;J3KRK0;J3QLK5;Q86UE8-3;Q86UE8-2;Q86UE8 Q9UKI8-3 TLK1;TLK2 Serine/threonine-protein kinase tousled-like 1;Serine/threonine-protein kinase tousled-like 2 0 54243800.0 13617800.0 22552700.0 18073300.0 False True 17628510.546969175 21297622.419583384 14784144.847718177 1.0 1.2081351038046166 0.8386496867292046 24.071407249063785 -6.753822076304286 1.6353582580688513 1.121815400564699 0.8376789588607957 0.6654365190201514 0.08748193098144114 0.29340027535522417 1.5448733624908522 0.042235335706724775 0.10214170812977623 1.762698048484545e-07 6.753822076304286 -0.2841364417039033 YLLSLK(ub)EK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLLSLKEK 8 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 4530400.0 1034000.0 1900400.0 1596000.0 True False 1355584.013270243 1616867.7277011797 1430861.2299130363 1.0 1.1927462347395272 1.0555312071445817 20.370483097307893 -10.274381745106597 4.675971492931564 0.9999497756938819 1.124138720942302 0.5218318341544874 0.05601780044276341 2.934353034142101e-05 4.553512793002264e-06 0.054260931179269764 0.01807966735033319 5.316407412963996e-11 10.274381745106597 0.12418894524842006 YLLSLK(ub)EK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLLSLKEK 8 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 5260300.0 1945500.0 1357800.0 1957000.0 True False 1883741.167412859 1899976.62083346 1444402.9912584485 1.0 1.0086187283590022 0.766773597267718 20.845169316576847 -6.898636894019927 0.9698610625804904 1.0104345573948514 0.7420804638257652 0.9858753835833713 0.013314514975787065 0.11241506248964829 0.18313970201670215 0.010322273070203088 0.026677295005663737 1.2628829675584844e-07 6.898636894019927 -0.26835409356908624 YLLSLK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLLSLKEK 8 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 14830700.0 2119800.0 3007400.0 9703500.0 True False 3215891.578138496 2470705.97307655 7785598.97180486 1.0 0.7682802460979442 2.4209768217097416 21.61678733706033 -6.871413028761096 1.1266457223251505 0.8677687116687693 2.5203801085514894 0.9660706139639641 0.13458004873925716 0.13550453725045197 0.3206123253944595 0.0926252790790306 0.2198398326414187 1.3445810037264425e-07 6.871413028761096 1.65261139688272 up YLLSLK(ub)EK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLLSLKEK 8 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 5354990.0 1034000.0 838490.0 3482500.0 True False 1416297.7427993277 801442.7392843643 2660005.2243388565 1.0 0.5658716490646268 1.8781398458500171 20.433693158830785 -6.817574378879339 1.3825934037239307 0.7654220144668977 1.9052649898220797 0.8786517195896906 0.19014993763513147 0.1966568859553612 0.7393538130356216 0.10809985634321635 0.2492973120622339 1.5220384406244406e-07 6.817574378879339 1.139842975355182 YLLSLK(ub)EK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLLSLKEK 8 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 6275800.0 1945500.0 2063300.0 2267000.0 True False 1617769.450263444 2052184.593367017 2741019.218576302 1.0 1.2685272261958163 1.6943200516797638 20.625574592011123 -6.964318203679392 0.3695728784505473 0.9670972522001722 2.0105611431887245 0.9998983853255736 0.0028816651284760916 0.07819316234878085 0.01568082041279332 0.005615937212924829 0.036170605632150986 1.085629900832637e-07 6.964318203679392 1.0434638909885523 YLLSLK(ub)EK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLLSLKEK 8 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 24146600.0 2119800.0 2291800.0 19735000.0 True False 2744122.8875049725 2164259.315345888 16143432.498200024 1.0 0.7886889195817642 5.882911647910218 21.38791365915278 -6.897219801756522 0.9786476235653144 0.7717438259224033 6.388497201869564 0.9851325209556276 0.2869328413598387 0.11348181349279199 0.18917273222624362 0.22098929717089372 0.5673785336156878 1.2670104540492351e-07 6.897219801756522 5.616753375947161 up YLLTPSMQK(ub)SVQNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLLTPSMQKSVQNK 14 1 K7ENR6;Q969U7-2;Q969U7;V9GZ55 K7ENR6 PSMG2 Proteasome assembly chaperone 2 1 22167900.0 3733300.0 6349600.0 12085000.0 True False 3614788.4350051037 8885028.392726557 8919575.95777126 1.0 2.45796636580033 2.4675236512862937 21.785479781451937 -10.808637527211037 0.8670192079427694 2.7285404567266996e-15 2.4652698582981722 0.9999938300524643 0.0017128036853486617 2.6671666521794957 0.4782423782277881 5.535708752256213 0.0013274841568468756 1.5536832109429483e-11 10.808637527211037 2.4652698582981696 YLLTPSMQK(ub)SVQNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLLTPSMQKSVQNK 14 1 K7ENR6;Q969U7-2;Q969U7;V9GZ55 K7ENR6 PSMG2 Proteasome assembly chaperone 2 1 21028300.0 3733300.0 10498000.0 6797000.0 True False 3104404.3632323407 10441445.190310158 8218221.274222817 1.0 3.3634294919745598 2.6472779678952367 21.565885056886213 -9.978124900533082 5.454306361423148 0.9999946473222272 3.0053537299386814 0.9126994622229438 0.29236763543177263 1.902987986360533e-05 3.5668688766403983e-06 0.2830845037112747 0.0943612485811816 1.051659379288922e-10 9.978124900533082 2.0053590826164545 YLLVPAFQGALTMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLLVPAFQGALTMK 14 0 P78318 P78318 IGBP1 Immunoglobulin-binding protein 1 0 4956400.0 1810000.0 1706900.0 1439500.0 False True 1752542.5407439086 2388474.07136591 1062451.7659256707 1.0 1.3628622506088013 0.6062345085641617 20.74101803357456 -6.776294667503547 1.5502991633433774 1.2064500049215903 0.6009217204059525 0.7540666686273967 0.15322726339917214 0.2563725542318493 1.2167707698381205 0.07786769829514936 0.18431293866794657 1.6738068177577597e-07 6.776294667503547 -0.6055282845156378 YLLVPAFQGALTMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLLVPAFQGALTMK 14 0 P78318 P78318 IGBP1 Immunoglobulin-binding protein 1 0 4694110.0 723110.0 1518000.0 2453000.0 False True 990463.3083129801 1450929.7406452831 1873651.9211208075 1.0 1.4649000406856045 1.8916924083862634 19.917744005941902 -6.972148469720112 0.20032933361790967 0.7470399372635537 2.6213404385693613 0.9999946476831476 0.0008424270654397659 0.07561152197206573 0.006470972536186819 0.01381907143967707 0.045271549988306195 1.0662315525586694e-07 6.972148469720112 1.8743005013058076 YLLVPAFQGALTMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLLVPAFQGALTMK 14 0 P78318 P78318 IGBP1 Immunoglobulin-binding protein 1 0 4873300.0 1810000.0 2000800.0 1062500.0 False True 1505095.196595648 1990021.2932722936 1284663.8375550592 1.0 1.3221896513745393 0.8535432446139094 20.521423309008835 -6.721681919658221 1.753081512788566 1.1956615180294556 0.8541948276358864 0.5205140018255967 0.13555139561708593 0.35206549205045995 2.115436358684852 0.06137075736000946 0.1537701987123492 1.898095590845782e-07 6.721681919658221 -0.34146669039356925 YLLVPAFQGALTMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLLVPAFQGALTMK 14 0 P78318 P78318 IGBP1 Immunoglobulin-binding protein 1 0 14665800.0 4316800.0 7167300.0 3181700.0 False True 5588182.696849455 6768433.454436949 2602663.2469988833 1.0 1.2112047550365352 0.4657441225867993 22.41394775748924 -6.83101437930974 1.3233564181103894 1.112775702610475 0.44526274248699577 0.9078956543932948 0.0952081179279116 0.17955886385226916 0.6146341172262216 0.056481928975917764 0.1299791506105872 1.4756576740549552e-07 6.83101437930974 -0.6675129601234793 down YLLYLQIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLLYLQIK 8 0 A2A2Y4-5;A2A2Y4-2;A2A2Y4 A2A2Y4-5 FRMD3 FERM domain-containing protein 3 0 7695800.0 786500.0 3036200.0 3873100.0 False True 1193178.0008519315 2494366.388061125 3107580.087359962 1.0 2.0905232800807108 2.604456405616885 20.18637785275157 -9.533530637965681 0.211102474902752 6.949938737388536e-19 3.0504997758806214 0.999392343456277 0.016490491373848976 0.9597815883787121 0.08514922957931628 0.8899156862560713 0.278468677490701 2.9273143522354795e-10 9.533530637965681 3.0504997758806214 YLLYLQIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLLYLQIK 8 0 A2A2Y4-5;A2A2Y4-2;A2A2Y4 A2A2Y4-5 FRMD3 FERM domain-containing protein 3 0 4606900.0 786500.0 1265000.0 2555400.0 False True 1018139.7542327854 1194601.63797563 2090343.420618206 1.0 1.1733179389265833 2.0531006788880126 19.95750417484402 -6.939469509450336 0.6644883856032959 0.9900287894311754 2.28668671933233 0.9980934895116513 0.020130967367604915 0.08800961619548524 0.055719713363441205 0.01951802091800708 0.07589990697194006 1.1495569476292859e-07 6.939469509450336 1.2966579299011547 up YLMEEDEDAYKK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLMEEDEDAYKK 12 1 P46777;A0A2R8Y6J3 P46777 RPL5 60S ribosomal protein L5 0 23738030.0 943630.0 12512400.0 10282000.0 False True 1237108.068125919 10645598.692953194 9218117.271908408 1.0 8.605229379095466 7.451343588659016 20.23854010241079 -10.493326832065781 6.960948434844897 0.9979110711111242 8.028286483877242 0.9801849115402381 0.4710719013362238 0.015258820910403325 0.0011106610831490892 0.455735375402846 0.1520378023951216 3.211242980418908e-11 10.493326832065781 7.0303754127661175 YLMEEDEDAYKK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLMEEDEDAYKK 12 1 P46777;A0A2R8Y6J3 P46777 RPL5 60S ribosomal protein L5 0 20897200.0 6146000.0 1981800.0 12769400.0 False True 5950898.59415031 2773143.0749504725 9424711.06621137 1.0 0.4660040884710171 1.583745869149206 22.504676103196953 -6.776785330027541 1.548322242596101 0.6963770397689384 1.591735359653195 0.7558790135386888 0.22553386677648088 0.2555994261296041 1.2100420055846115 0.11475308954360583 0.271514039045614 1.67191683169506e-07 6.776785330027541 0.8953583198842565 YLMEEDEDAYKK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLMEEDEDAYKK 12 1 P46777;A0A2R8Y6J3 P46777 RPL5 60S ribosomal protein L5 0 20859230.0 943630.0 10428600.0 9487000.0 False True 1292515.5116419056 9967829.96923151 7246365.990898136 1.0 7.711961581466204 5.606405436243429 20.301750163933683 -9.903275867682732 8.095561764284675 0.999999982850271 6.659183508854817 0.905943566312704 0.8595896967628799 1.1521417210172977e-07 1.8383627404904517e-08 0.8322941450335128 0.277431381677843 1.2494651068423295e-10 9.903275867682732 5.659183526004545 YLMEEDEDAYKK(ub) ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLMEEDEDAYKK 12 1 P46777;A0A2R8Y6J3 P46777 RPL5 60S ribosomal protein L5 1 3974400.0 1243300.0 1245600.0 1485500.0 True False 1033859.0375289347 1238889.7055677576 1796111.181824039 1.0 1.1983158831100171 1.737288272990283 19.97960806279 -6.9536483525525785 0.5172423990347134 0.9906423565697245 1.9689013056075328 0.9994573662792768 0.007256750258366371 0.08205298984186195 0.030149059230211966 0.008257532500751055 0.04450786942480632 1.1126322589573968e-07 6.9536483525525785 0.9782589490378083 YLNFFTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLNFFTK 7 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 148467000.0 47567000.0 39612000.0 61288000.0 False True 62360797.63948329 33702044.00636664 54946505.6760089 1.0 0.5404363844286115 0.881106524545477 25.89413604547314 -10.281906377123173 5.817784572117648 1.0000192099906322 0.710771454487043 0.49007307851839366 0.13907800231480127 3.465553075944587e-05 4.277459486154741e-06 0.13467063158445616 0.04488723223241758 5.225088165091668e-11 10.281906377123173 -0.28924775550358917 YLNFFTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLNFFTK 7 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 89927000.0 37059000.0 10184000.0 42684000.0 False True 35882582.33007103 14250524.308858404 31503779.90744796 1.0 0.39714322056793266 0.8779685814598281 25.096780383363047 -10.02904792258885 7.092664958160483 1.0000000470547274 0.6375559010139021 0.4310457775904002 0.1962961315957869 1.4599851657854428e-07 1.9965406992899804e-08 0.19006293763816634 0.06335430404961845 9.353024617185456e-11 10.02904792258885 -0.3624441460408253 YLNFFTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLNFFTK 7 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 123599000.0 43691000.0 60188000.0 19720000.0 False True 66282441.23995143 49446981.14900962 15822333.35641697 1.0 0.7460042241052173 0.23871078162522677 25.982123403462396 -7.061406260124823 0.46308291508492044 1.0147531331548298 6.846036630964059e-14 0.9996934070130717 0.005541452792825303 0.07401696808106993 0.024097332328212675 0.007200931935394011 0.03874615761629119 8.681479416292587e-08 7.061406260124823 -1.0147531331547615 down YLNFFTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLNFFTK 7 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 130162000.0 47567000.0 38561000.0 44034000.0 False True 65153805.349841096 36857247.515825294 33634076.108696975 1.0 0.5656960068244914 0.5162258125691964 25.95734610699603 -13.999999999999998 0.30663073630406207 5.116424751890607 0.5048699899678032 0.9996645660208227 0.003980428074611247 17.033385207765495 0.17607038806851372 44.65242995326723 0.017383490472556357 1.0000000000000041e-14 13.999999999999998 -4.611554761922804 YLNFFTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLNFFTK 7 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 78068000.0 37059000.0 27570000.0 13439000.0 False True 30816200.49206529 27421474.937783502 16249032.765084637 1.0 0.8898395811269504 0.527288650308091 24.877185658797323 -6.949352089036942 0.565911823739847 1.0046030147930076 0.39502156674098204 0.999149453246803 0.005889536066275309 0.08374695905092608 0.0370471397047327 0.006269098037987132 0.030178037197189096 1.1236936093599732e-07 6.949352089036942 -0.6095814480520256 YLNFFTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLNFFTK 7 0 P12004 P12004 PCNA Proliferating cell nuclear antigen 0 132641000.0 43691000.0 44778000.0 44172000.0 False True 56558860.77836578 42286064.93697451 36133149.242994204 1.0 0.7476470415958107 0.6388592122565422 25.753249725554845 -13.999999999997312 0.11471719183608217 2.209064606415314 0.4521912612479778 0.9997192058246296 0.0025347869825860063 11.987034269811135 0.1035180250883953 3.3296563056152046 0.16566258161386993 1.0000000000061885e-14 13.999999999997312 -1.7568733451673362 YLNK(ub)EIEEAPDIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLNKEIEEAPDIR 13 1 A0A0J9YWJ4;K7EJD2;A0A0J9YWB6;A0A0A0MR03;Q9Y5B0-4;Q9Y5B0 A0A0J9YWJ4 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 1 23953200.0 3378000.0 6445200.0 14130000.0 True False 5124672.964879635 5295003.703422549 11337199.306600979 1.0 1.0332373869923455 2.21227761933239 22.28902851013727 -6.912933417461339 0.8755179090288842 0.9667934692630781 2.3746122187955825 0.9919823158574528 0.05048371846887024 0.10251018185515416 0.12848081275462453 0.0419407377772249 0.11826977474317692 1.2219869910263534e-07 6.912933417461339 1.4078187495325043 up YLNK(ub)EIEEAPDIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLNKEIEEAPDIR 13 1 A0A0J9YWJ4;K7EJD2;A0A0J9YWB6;A0A0A0MR03;Q9Y5B0-4;Q9Y5B0 A0A0J9YWJ4 CTDP1 RNA polymerase II subunit A C-terminal domain phosphatase 1 24317600.0 3378000.0 5750600.0 15189000.0 True False 4372887.590334846 5430574.054816326 12424757.85230099 1.0 1.2418736916126605 2.841316543275147 22.06015483222972 -6.933814454705066 0.714795346199013 0.978779489591935 3.2040160005435667 0.9972361537251605 0.042950728418764746 0.0907050943530052 0.06832984158138962 0.04005920415536917 0.1418093059570265 1.1646234896912232e-07 6.933814454705066 2.225236510951632 up YLNNVVEQLKDWLYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLNNVVEQLKDWLYK 15 1 Q13257 Q13257 MAD2L1 Mitotic spindle assembly checkpoint protein MAD2A 0 61205000.0 21638000.0 16105000.0 23462000.0 False True 32826427.949693732 13230936.92106066 18824725.4162401 1.0 0.4030574676397011 0.5734624993340384 24.96835443393241 -10.818153446824084 10.835521111192165 1.0054783176811768 0.4882599834870361 0.9232225406248874 0.0695675628756536 0.009134657579388932 0.00015330161211469785 0.06683111691835399 0.02245283437113699 1.5200103781349118e-11 10.818153446824084 -0.5172183341941408 YLNNVVEQLKDWLYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLNNVVEQLKDWLYK 15 1 Q13257 Q13257 MAD2L1 Mitotic spindle assembly checkpoint protein MAD2A 0 38949100.0 21638000.0 9302300.0 8008800.0 False True 28010817.548746392 8784618.827621123 6551280.577227483 1.0 0.3136152242730335 0.23388394736520932 24.73948075602486 -13.999999999999998 0.3038027661112073 7.399825627200812 0.21502824986533065 0.9996582977234133 0.006357084493774868 16.84045860652881 0.1751639606709421 67.89409360350942 0.02835129470105068 1.0000000000000041e-14 13.999999999999998 -7.184797377335482 YLNTNPVGGLLEYAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLNTNPVGGLLEYAR 15 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 14081700.0 2175500.0 5587900.0 6318300.0 False True 2852101.5675719674 4754207.101463598 5664542.925413235 1.0 1.6669136735936507 1.9860943908233735 21.44359392853349 -10.169571716687013 0.16632082894611774 4.2794902818283575e-15 2.377813131779189 0.9996191275698229 0.008017738899839219 1.791664805004522 0.08047740562528213 1.0194601968386567 0.24803294750703617 6.767500294053297e-11 10.169571716687013 2.3778131317791846 YLNTNPVGGLLEYAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLNTNPVGGLLEYAR 15 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 14394500.0 6263700.0 3669500.0 4461300.0 False True 6064862.272076037 5134750.486189697 3292751.6938688406 1.0 0.8466392567282559 0.5429227484735136 22.532043452650335 -6.960237068767085 0.43208154844311886 1.0118010927164405 0.36607380472925555 0.9997788855539956 0.0028243341066069645 0.07961657167253547 0.020819370921911624 0.003968551697375819 0.025205917458335503 1.0958798238157076e-07 6.960237068767085 -0.6457272879871849 YLNTNPVGGLLEYAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLNTNPVGGLLEYAR 15 0 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISX1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 0 20176600.0 2175500.0 10320000.0 7681100.0 False True 2979841.140676922 9864028.276323682 5866982.377220162 1.0 3.3102530674111366 1.9688909912450487 21.50680399005638 -10.113936741402231 4.7465850162766365 0.9999011542194013 2.6395720293435505 0.6657848064213965 0.547608774552955 0.0005916100236749411 0.00011043935742317461 0.5302522450206283 0.17673997199746 7.692424786817342e-11 10.113936741402231 1.6396708751241493 YLPQCSYFK(ub)CVQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLPQCSYFKCVQK 13 1 P30279;A0A3B3IT44;P30279-2 P30279 CCND2 G1/S-specific cyclin-D2 1 150444400.0 47110000.0 57932400.0 45402000.0 True False 61761666.21388897 49289111.73872651 40704236.56673659 1.0 0.798053465203346 0.6590534074286845 25.880208338548243 -7.537357725396545 0.07918693800948767 1.5318373985594416 2.82517982861296e-10 0.9999988248847292 0.00015163158046039676 0.13579539719943817 0.007209096579453415 0.05906395797324959 0.07726245642564532 2.9016316157279207e-08 7.537357725396545 -1.5318373982769236 YLPQCSYFK(ub)CVQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLPQCSYFKCVQK 13 1 P30279;A0A3B3IT44;P30279-2 P30279 CCND2 G1/S-specific cyclin-D2 1 188588000.0 47110000.0 48348000.0 93130000.0 True False 64527840.09988044 46211825.494544245 71134612.07255642 1.0 0.7161532979100886 1.102386380242227 25.943418400071135 -6.709758202673437 1.7959625259454777 0.8254529914678407 1.1014757605735992 0.4639571395048838 0.11961626543359764 0.3755848795500188 2.3613282997850997 0.05300366978231883 0.13469897834414618 1.9509304953939204e-07 6.709758202673437 0.2760227691057585 YLQDNPASGEK(ub)FAYVPFGAGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLQDNPASGEKFAYVPFGAGR 21 1 A0A0C4DFL7;Q16850-2;Q16850 A0A0C4DFL7 CYP51A1 Lanosterol 14-alpha demethylase 1 53559000.0 10784000.0 16803000.0 25972000.0 True False 14137928.432404555 14296057.89758102 23284666.58101591 1.0 1.0111847691076175 1.6469645247069407 23.753067408174818 -6.910716275280758 0.8908453350784845 0.9807580258164326 1.7303990431122733 0.9911889816817187 0.02838352953454037 0.10394631626502539 0.1362131783870899 0.02332056438546922 0.06469910192096624 1.2282413795808276e-07 6.910716275280758 0.7496410172958408 YLQDNPASGEK(ub)FAYVPFGAGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLQDNPASGEKFAYVPFGAGR 21 1 A0A0C4DFL7;Q16850-2;Q16850 A0A0C4DFL7 CYP51A1 Lanosterol 14-alpha demethylase 1 88421000.0 10666000.0 15299000.0 62456000.0 True False 10327413.668273227 21407970.483231008 46096899.96016237 1.0 2.0729265981664198 4.463547354724089 23.299975664286986 -6.957878595749085 0.4643657849575077 0.9332740395251243 5.700279366262137 0.9996832495755338 0.02576533568243738 0.08046780308141109 0.023998506377936657 0.03271503596458599 0.19740231140333186 1.1018472808695e-07 6.957878595749085 4.767005326737013 YLQDNPASGEK(ub)FAYVPFGAGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLQDNPASGEKFAYVPFGAGR 21 1 A0A0C4DFL7;Q16850-2;Q16850 A0A0C4DFL7 CYP51A1 Lanosterol 14-alpha demethylase 1 463766000.0 15388000.0 119130000.0 329248000.0 True False 23344721.01348956 97870320.73306175 264171988.4854753 1.0 4.192396245665483 11.316133884522571 24.4765930116325 -6.957847836696826 0.46477200683652237 0.8019607700141679 14.996050974247357 0.9996818644933068 0.07691530915591399 0.08047905336466057 0.024041095680409064 0.09755725013927227 0.5882111564972722 1.1019253223361377e-07 6.957847836696826 14.19409020423319 YLQDNPASGEK(ub)FAYVPFGAGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLQDNPASGEKFAYVPFGAGR 21 1 A0A0C4DFL7;Q16850-2;Q16850 A0A0C4DFL7 CYP51A1 Lanosterol 14-alpha demethylase 1 67816100.0 10784000.0 8702100.0 48330000.0 True False 14771136.226642128 8317612.448003513 36915449.38759426 1.0 0.5630990277512543 2.499161122149242 23.81627746969771 -6.84743397623035 1.247519260542174 0.767282159333007 2.5727623521793697 0.936471929259053 0.2089734973124201 0.16030340968354373 0.4813968786299883 0.1311642503499825 0.3030463717031737 1.4209082105060708e-07 6.84743397623035 1.8054801928463626 up YLQDNPASGEK(ub)FAYVPFGAGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLQDNPASGEKFAYVPFGAGR 21 1 A0A0C4DFL7;Q16850-2;Q16850 A0A0C4DFL7 CYP51A1 Lanosterol 14-alpha demethylase 1 89044000.0 10666000.0 21427000.0 56951000.0 True False 8869251.583916683 21311568.498073526 68859190.78832772 1.0 2.402859846339175 7.763810749623515 23.080380939721262 -6.945924651659239 0.6019260513700905 0.9398631734099046 9.502145499213642 0.9988414101022138 0.09920923185912528 0.085164665485457 0.04306156085827005 0.10163020457112748 0.45080551509351 1.1325968471748143e-07 6.945924651659239 8.562282325803737 YLQDNPASGEK(ub)FAYVPFGAGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLQDNPASGEKFAYVPFGAGR 21 1 A0A0C4DFL7;Q16850-2;Q16850 A0A0C4DFL7 CYP51A1 Lanosterol 14-alpha demethylase 1 401337000.0 15388000.0 84327000.0 301622000.0 True False 19920069.342827868 79634128.32060951 246729890.90306994 1.0 3.997683288651875 12.38599558348947 24.247719333724948 -6.953004454029147 0.5248260157551699 0.8625934824387572 15.898525874532123 0.9994164501365104 0.11640758995320431 0.0823013019309106 0.03113973512070286 0.13088439872184504 0.6932330277065133 1.1142831056894949e-07 6.953004454029147 15.035932392093365 YLQEFAPLGTGGGLYHFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLQEFAPLGTGGGLYHFR 18 0 Q96IJ6;Q96IJ6-2;A0A087WUI8;C9JAH0;F8WD54;C9J255 Q96IJ6 GMPPA Mannose-1-phosphate guanyltransferase alpha 0 7594370.0 897070.0 2769500.0 3927800.0 False True 1228741.021405215 2647134.3324882183 3000134.5355802337 1.0 2.154346836618914 2.441632926154947 20.228749443939677 -10.391362407760196 0.3022511016028794 1.6698948710050123e-13 2.5329680562345556 0.9990408049168157 0.01929539102593344 1.9097973539873563 0.14416757781884987 1.5992630593866313 0.1018473593425434 4.0610430396116735e-11 10.391362407760196 2.5329680562343886 YLQLAEELIRPER ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLQLAEELIRPER 13 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 13327600.0 6113400.0 2857100.0 4357100.0 False True 5919333.463305972 3997954.9295796673 3215844.799801834 1.0 0.6754062690272552 0.5432781950428878 22.497003302049816 -13.999999999999998 0.12367730579494879 2.543830417719371 0.3424760551842501 0.9996751052725866 0.0034588738055094086 11.95115784752451 0.10868897282458695 4.51432203311433 0.17826917113121646 1.0000000000000041e-14 13.999999999999998 -2.201354362535121 YLQLAEELIRPER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLQLAEELIRPER 13 1 Q14566 Q14566 MCM6 DNA replication licensing factor MCM6 0 12008500.0 6113400.0 3565100.0 2330000.0 False True 5083562.969540239 3545894.0986830527 2817192.2272972143 1.0 0.697521427378669 0.5541767150672283 22.277408577484092 -13.999999999870797 0.09926563871195808 2.497075734307154 0.24536195747852704 0.9997973904969902 0.002645134127731362 12.086045190502228 0.09367900212044362 3.7135496135239263 0.2755398046867094 1.0000000002975017e-14 13.999999999870797 -2.251713776828627 YLQMK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLQMKAK 7 1 O00154-4;O00154-6;O00154-7;O00154;O00154-5 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 1 9081900.0 3762700.0 4178900.0 1140300.0 True False 3643255.148097851 5847556.562675604 841621.2217332688 1.0 1.6050362450537186 0.23100803746141155 21.796796604208755 -6.787005671863167 1.5082088516318226 1.3394769816431333 0.21756323730673863 0.791492787940708 0.2567489860744787 0.23984744853346346 1.07783209412224 0.13401653313372158 0.31447248521234317 1.6330306204607722e-07 6.787005671863167 -1.1219137443363947 YLQMK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLQMKAK 7 1 O00154-4;O00154-6;O00154-7;O00154;O00154-5 O00154-4 ACOT7 Cytosolic acyl coenzyme A thioester hydrolase 1 13048660.0 3762700.0 8322900.0 963060.0 True False 3128851.7658731765 8278062.885733702 1164431.39331367 1.0 2.6457191024591484 0.3721593352597544 21.57720187964303 -6.712507929159969 1.786003086498977 2.0091330973383212 0.3770347887382947 0.4771154090624973 0.6932305973372823 0.3700620344877578 2.3024961778016575 0.3086876014123424 0.7819127620523396 1.9386172411977504e-07 6.712507929159969 -1.6320983086000265 YLQQPGCLLVGTNMDNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLQQPGCLLVGTNMDNR 17 0 A6NDG6 A6NDG6 PGP Phosphoglycolate phosphatase 0 8330200.0 2369800.0 4190500.0 1769900.0 False True 3106830.749175845 3565293.734441068 1586767.7260796244 1.0 1.1475661284049157 0.5107351684672714 21.56701221922436 -6.845699915992966 1.2556393691687384 1.0785462354781499 0.4873093781746773 0.9338143951649692 0.07002108558064396 0.16225111282066865 0.49443071885542517 0.04368015707986258 0.10084055509988953 1.4265929845983712e-07 6.845699915992966 -0.5912368573034725 YLQQPGCLLVGTNMDNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLQQPGCLLVGTNMDNR 17 0 A6NDG6 A6NDG6 PGP Phosphoglycolate phosphatase 0 7921400.0 2369800.0 2333500.0 3218100.0 False True 3245979.101436991 2230398.2541474127 2458051.058849926 1.0 0.6871264984916318 0.757260284812601 21.63022228074725 -9.909341142818391 5.305833985220761 1.0000004538242953 0.7221933916497193 0.9543803251105747 0.028631998377688535 1.5370471223756323e-07 3.1610487814151475e-08 0.02772285824502011 0.009240937739240456 1.232136596926931e-10 9.909341142818391 -0.27780706217457596 YLQWEIGNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLQWEIGNK 9 0 Q7L0Y3 Q7L0Y3 TRMT10C Mitochondrial ribonuclease P protein 1 0 8995600.0 3637300.0 2297000.0 3061300.0 False True 4768535.5236633 1954296.5536358734 2744546.042063141 1.0 0.40983160216336967 0.5755532339947248 22.1851148340565 -10.734670432777184 10.44879960699788 1.0008568323900138 0.49269241807920683 0.9258963919026695 0.06765557288803244 0.0013521233425278997 3.433481504355535e-05 0.06558998497560206 0.021835742256122635 1.8421694135548473e-11 10.734670432777184 -0.5081644143108069 YLQWEIGNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLQWEIGNK 9 0 Q7L0Y3 Q7L0Y3 TRMT10C Mitochondrial ribonuclease P protein 1 0 4496050.0 1468200.0 559250.0 2468600.0 False True 1421592.7946520478 782561.4414502231 1821999.6035874344 1.0 0.550482138341004 1.2816606910514 20.439076843517174 -6.74036644602837 1.6853109796233041 0.7326502018724139 1.282126414907308 0.6065822345307751 0.18886715168705276 0.3171652786742235 1.7689308724597725 0.08864978836219611 0.2174548356283018 1.8181660914507809e-07 6.74036644602837 0.549476213034894 YLRPHLEATLQLSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLRPHLEATLQLSLK 15 1 O00410;O00410-3;H0Y8C6;O00410-2 O00410 IPO5 Importin-5 0 136269000.0 0.0 89765000.0 46504000.0 False True 0.0 73745734.41285388 37312464.01657272 0.0 YLRPPNTSLFVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLRPPNTSLFVR 12 1 Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3;O75494-2;O75494;Q6IQ42;R4GMP8 Q5JRI1 SRSF10;FUSIP1 Serine/arginine-rich splicing factor 10 0 107071000.0 40422000.0 25657000.0 40992000.0 False True 52993633.44720482 21829075.610202674 36750541.06302954 1.0 0.41191883232445275 0.6934897396616984 25.659315711701396 -10.471950121204873 6.229521200390843 1.0002296660610401 0.5527042859930931 0.7708917412859327 0.1149508415647894 0.00036684579965383504 3.109599785755838e-05 0.11135660506438518 0.03710022458441305 3.373260483882357e-11 10.471950121204873 -0.44752538006794707 YLRPPNTSLFVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLRPPNTSLFVR 12 1 Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3;O75494-2;O75494;Q6IQ42;R4GMP8 Q5JRI1 SRSF10;FUSIP1 Serine/arginine-rich splicing factor 10 0 89625000.0 40422000.0 25788000.0 23415000.0 False True 55367105.76347625 24648600.890487887 17884859.24706225 1.0 0.44518492615064065 0.32302319220847314 25.722525773224287 -13.999999999999998 0.21265634854004276 4.244245616964336 0.2528959437956593 0.9994916689669745 0.00664184549443777 12.810157870851908 0.14614459393334825 17.386920818973007 0.07103889459936463 1.0000000000000041e-14 13.999999999999998 -3.991349673168677 YLRPPNTSLFVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLRPPNTSLFVR 12 1 Q5JRI1;O75494-5;O75494-4;O75494-6;O75494-3;O75494-2;O75494;Q6IQ42;R4GMP8 Q5JRI1 SRSF10;FUSIP1 Serine/arginine-rich splicing factor 10 0 73173000.0 32123000.0 24799000.0 16251000.0 False True 26711697.790188935 24665402.864783887 19649008.96386568 1.0 0.9233933035077747 0.7355956599315322 24.670968340508143 -6.955880575104011 0.49005396116071287 1.004107799272267 0.6469169739585634 0.9995855942534825 0.0022612160407252035 0.08120683817598293 0.026828630384927877 0.002704204718325274 0.015488988430976432 1.1069281318529717e-07 6.955880575104011 -0.3571908253137035 YLSEVASGDNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLSEVASGDNK 11 0 P31946;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 0 15687830.0 680530.0 9653200.0 5354100.0 False True 892181.4202618939 8212980.187878887 4800109.092153747 1.0 9.205504621994955 5.380193964075946 19.766977578639835 -9.347240870443517 10.716008246621344 1.0000005368199238 7.292849293035453 0.7829991977352841 1.5616765365886704 0.0 0.0 1.5120868045926814 0.5040289348642271 4.495304650448132e-10 9.347240870443517 6.2928487562155295 YLSEVASGDNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLSEVASGDNK 11 0 P31946;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 0 15297300.0 3770200.0 1681500.0 9845600.0 False True 3650517.0647031437 2352931.7189066606 7266741.998331211 1.0 0.6445475194889956 1.990606226332525 21.799669393275906 -6.836495574660499 1.2985414820451067 0.8107393389257984 2.031902793059515 0.9182651418437526 0.16283142312180862 0.17293096921723702 0.5679346616859839 0.09837907100492882 0.22648146772553457 1.4571505526120185e-07 6.836495574660499 1.2211634541337166 YLSEVASGDNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLSEVASGDNK 11 0 P31946;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 0 12333930.0 680530.0 5782000.0 5871400.0 False True 932140.3316317467 5526532.121482891 4484696.245278732 1.0 5.928862783791887 4.811181420964912 19.830187640162727 -10.243526615161569 5.984270028127247 0.9998701198954651 5.370022102378418 0.9532340704281821 0.45629150565750015 0.0007906944038338319 9.995740815297391e-05 0.441814053737675 0.14726745020227405 5.707860952308565e-11 10.243526615161569 4.370151982482954 YLSEVASGDNK(ub)QTTVSNSQQAYQEAFEISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLSEVASGDNKQTTVSNSQQAYQEAFEISK 30 1 P31946;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 15001800.0 7540500.0 5109500.0 2351800.0 True False 9885668.52230587 4347182.51667501 2108458.2960585705 1.0 0.4397459318877721 0.2132843409933357 23.236907101409482 -10.901057716460802 0.1817935598750147 1.9587277494594435 4.78256606536914e-15 0.9994777257484169 0.007556932735005949 2.942917857401209 0.10098201944889194 1.354671520402792 0.15902937521047564 1.255863052093863e-11 10.901057716460802 -1.9587277494594386 YLSEVASGDNK(ub)QTTVSNSQQAYQEAFEISK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLSEVASGDNKQTTVSNSQQAYQEAFEISK 30 1 P31946;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 83304000.0 34664000.0 24057000.0 24583000.0 True False 33563610.294114254 33663085.55559764 18143974.8258081 1.0 1.0029637831154543 0.540584718592977 25.00039457287586 -6.905454919432794 0.9261189423845401 1.0164541853446734 0.4862913412190348 0.9890907011828084 0.022693575491907526 0.1075012242382976 0.15563317653471243 0.018171727431925726 0.048715547489324995 1.2432116768092514e-07 6.905454919432794 -0.5301628441256385 YLSEVASGDNK(ub)QTTVSNSQQAYQEAFEISK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLSEVASGDNKQTTVSNSQQAYQEAFEISK 30 1 P31946;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 211795000.0 88502000.0 82651000.0 40642000.0 True False 134264004.3628706 67901283.2947896 32609090.88597861 1.0 0.5057296154468564 0.2428729207111026 27.000497334990335 -9.140309677543256 0.21019357041265824 1.4058308257408607 4.30877938460482e-12 0.9994809548310555 0.007150796462155556 0.5800609159307304 0.07335826597861386 0.2943253654206289 0.1342230470966252 7.239195786970395e-10 9.140309677543256 -1.405830825736552 down YLSEVASGDNK(ub)QTTVSNSQQAYQEAFEISK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLSEVASGDNKQTTVSNSQQAYQEAFEISK 30 1 P31946;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 18911000.0 7540500.0 2531600.0 8838900.0 True False 10328426.624350417 2419745.5411183164 6751333.862859654 1.0 0.23428016958686587 0.6536652782082638 23.300117162932374 -10.39230886846145 10.148104365518753 1.0000003786021554 0.44397272390655645 0.7009315061656638 0.1712132536406872 1.466379699720819e-06 8.787513256391916e-08 0.16577663114893118 0.055258840000030694 4.052202419631887e-11 10.39230886846145 -0.5560276546955989 YLSEVASGDNK(ub)QTTVSNSQQAYQEAFEISK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLSEVASGDNKQTTVSNSQQAYQEAFEISK 30 1 P31946;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 102634000.0 34664000.0 48100000.0 19870000.0 True False 28824651.87557542 47840875.752897486 24024725.13150025 1.0 1.659720851422857 0.8334784140743643 24.780799848310135 -6.694039882689471 1.8519649583469953 1.4120287373925962 0.836181886884832 0.3894037863724513 0.27879143620009245 0.4080643939287532 2.7165222053916995 0.12028738723918204 0.3116620768307432 2.0228334067091143e-07 6.694039882689471 -0.5758468505077642 YLSEVASGDNK(ub)QTTVSNSQQAYQEAFEISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLSEVASGDNKQTTVSNSQQAYQEAFEISK 30 1 P31946;P31946-2 P31946;P31946-2 YWHAB 14-3-3 protein beta/alpha;14-3-3 protein beta/alpha, N-terminally processed 1 195553000.0 88502000.0 79389000.0 27662000.0 True False 114567583.6352321 74970932.36146042 22627799.83608858 1.0 0.6543817193540352 0.1975061279823486 26.771623657082785 -7.39368733236777 0.41755893433394625 1.0293878616586019 5.299125799167834e-25 0.9990705478451128 0.010019968676804814 0.1114132250904059 0.042473097733079085 0.015313771918143041 0.05988942242704808 4.03936099611061e-08 7.39368733236777 -1.0293878616586019 down YLSFHFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLSFHFK 7 0 P53004 P53004 BLVRA Biliverdin reductase A 0 95951000.0 33471000.0 46786000.0 15694000.0 False True 43880805.13362508 39805711.170399606 14070135.427478187 1.0 0.907132652857757 0.3206444226497679 25.38708666104726 -6.934761695016268 0.7066224857526575 1.007540918042095 0.1842148876720264 0.9973939643975696 0.015353671428355085 0.09023993327635287 0.06611525930498627 0.014407703572177077 0.051748479831852864 1.16208609590653e-07 6.934761695016268 -0.8233260303700685 down YLSFHFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLSFHFK 7 0 P53004 P53004 BLVRA Biliverdin reductase A 0 40371000.0 17121000.0 11780000.0 11470000.0 False True 16577503.226561565 16483815.431888446 8465662.907375773 1.0 0.9943484978773519 0.5106717695467875 23.982723400001596 -6.909451753952248 0.8994612467322226 1.0152364981493291 0.4488923893646671 0.9907129999874484 0.022102351715072858 0.10478166757872985 0.14074245155863488 0.018046581120813022 0.04962945937349817 1.2318228221093822e-07 6.909451753952248 -0.5663441087846621 YLSFHFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLSFHFK 7 0 P53004 P53004 BLVRA Biliverdin reductase A 0 178088000.0 65446000.0 56489000.0 56153000.0 False True 99286366.74349076 46408096.59942855 45054334.937265754 1.0 0.4674166063436003 0.4537816863987475 26.565092295541525 YLSFHFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLSFHFK 7 0 P53004 P53004 BLVRA Biliverdin reductase A 0 104745000.0 33471000.0 42287000.0 28987000.0 False True 45846133.219764344 40418620.515591 22140867.606004413 1.0 0.8816146025193345 0.4829386046555274 25.45029672257015 -6.948827503405204 0.5715726232007055 1.0049316786674942 0.34018582823664517 0.9991060168340343 0.006613366543764473 0.08396003746938151 0.037937676092843674 0.00699395495215302 0.03323045734693648 1.1250517423857052e-07 6.948827503405204 -0.664745850430849 down YLSFHFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLSFHFK 7 0 P53004 P53004 BLVRA Biliverdin reductase A 0 39266400.0 17121000.0 15135000.0 7010400.0 False True 14236870.088902801 15053464.750937732 8476242.227572702 1.0 1.0573577378269006 0.595372590649659 23.763128675435873 -6.875804566384273 1.1029949966270483 1.033906840062947 0.5651640443957953 0.9701378191120527 0.035529132210811366 0.13140813869479825 0.29533323271756723 0.024900856605303483 0.0596217900388484 1.3310532605627869e-07 6.875804566384273 -0.4687427956671517 YLSFHFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLSFHFK 7 0 P53004 P53004 BLVRA Biliverdin reductase A 0 299206000.0 65446000.0 125910000.0 107850000.0 False True 84721137.13352683 118902997.8162147 88222406.63444997 1.0 1.4034631951270284 1.041326988982748 26.336218617633975 -10.535604781975355 6.846729316724028 0.9998529257272385 1.2223950920548867 0.33460107576155174 0.1478414870734716 0.0003321262094833305 2.2527146840932117e-05 0.1432407998642714 0.04771563477617453 2.91336714358422e-11 10.535604781975355 0.22254216632764823 YLSGIAHFLEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLSGIAHFLEK 11 0 Q10713 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 20806100.0 6170300.0 6612400.0 8023400.0 False True 8089323.053270199 5625855.694933317 7193215.533887368 1.0 0.6954668095075028 0.8892234228399902 22.947587546571153 -10.698876735696231 5.732622106742142 1.0039004639455034 0.7923451161737479 0.604973413877305 0.07910080615905575 0.004006724350027173 0.00021046496023141808 0.07782224418185776 0.02552967541046698 2.000429564083958e-11 10.698876735696231 -0.21155534777175544 YLSGIAHFLEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLSGIAHFLEK 11 0 Q10713 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 15390200.0 4072900.0 3615100.0 7702200.0 False True 3943608.018892747 5058628.282497455 5684762.758952892 1.0 1.2827411492884058 1.4415131351084463 21.911084729228776 -11.489272504698029 0.08940138211103367 3.507541597011886e-17 1.9047317335144702 0.9999110121266921 0.0017225182305260493 4.44586305597626 0.060877867290431514 1.2025054737962808 0.3227609727119077 3.241361693434484e-12 11.489272504698029 1.9047317335144702 YLSGIAHFLEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLSGIAHFLEK 11 0 Q10713 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 13640100.0 2364900.0 8866700.0 2408500.0 False True 3587726.1973486757 7284368.109156706 1932458.9193169489 1.0 2.030357866924138 0.5386305456489497 21.774638362368446 -6.72088569814789 1.7560799732366867 1.626273447903 0.5408406488899069 0.5166612942395239 0.43353385074947465 0.35362879018352167 2.131709149984068 0.195983928434106 0.49149014116945344 1.9015786900714978e-07 6.72088569814789 -1.0854327990130932 YLSGIAHFLEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLSGIAHFLEK 11 0 Q10713 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 20186000.0 6170300.0 6007900.0 8007800.0 False True 8451626.656087715 5742451.112531498 6116522.565817856 1.0 0.6794492168433878 0.7237095076143856 23.010797608094045 -10.541402342005041 6.8748627214272355 1.0002099098948622 0.7015793622288866 0.9837697360431257 0.018069188042693345 5.817521774754674e-05 3.880657660982723e-06 0.017507528784988194 0.0058318053640701185 2.8747339504148385e-11 10.541402342005041 -0.29863054766597563 YLSGIAHFLEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLSGIAHFLEK 11 0 Q10713 Q10713 PMPCA Mitochondrial-processing peptidase subunit alpha 0 8557600.0 2364900.0 6192700.0 0.0 False True 3061409.669148271 5848070.801179203 0.0 1.0 1.9102542401018228 0.0 21.545764684460895 -6.784650614823663 1.5671092129401951 1.5169198379550775 1.4778980515151022e-18 0.7567879646837233 0.38474039215471095 0.24993587668789707 1.220430615488311 0.19483760921674503 0.4487112218040974 1.6419101408270622e-07 6.784650614823663 -1.5169198379550775 YLSLHDNK(ub)YIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLSLHDNKYIR 11 1 Q6UXN9 Q6UXN9 WDR82 WD repeat-containing protein 82 1 23453300.0 7005600.0 2371700.0 14076000.0 True False 10628007.377963515 1948451.60482332 11293872.430270037 1.0 0.18333178887919369 1.0626519185230479 23.341367798671946 -12.05272507548726 18.53515448020661 0.9473593367598367 0.6606926688791102 0.0 0.4101114129440898 0.0 0.0 0.0 0.11921970442459195 8.856760982223871e-13 12.05272507548726 -0.2866666678807266 YLSLHDNK(ub)YIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLSLHDNKYIR 11 1 Q6UXN9 Q6UXN9 WDR82 WD repeat-containing protein 82 1 11619200.0 4705500.0 5703500.0 1210200.0 True False 3912831.7389949327 5672774.113443886 1463247.2246674206 1.0 1.4497873897590647 0.3739611928836165 21.899781641603028 -6.793115464950799 1.4836607359726728 1.2503659450761009 0.3614811500077479 0.8113448192556378 0.19161740583434098 0.23072226278646624 1.0031957856811444 0.10163647814540835 0.2374481773738133 1.6102174731665004e-07 6.793115464950799 -0.8888847950683529 down YLSNAYAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLSNAYAR 8 0 O00299 O00299 CLIC1 Chloride intracellular channel protein 1 0 7094190.0 782390.0 3493100.0 2818700.0 False True 1071660.726294746 3338763.291863004 2152981.112948727 1.0 3.11550401161638 2.0090137299261057 20.03141680910909 -9.93962245222664 10.555184187523425 0.9999980958184864 2.562258870771243 0.7266240795352223 0.4517227659162705 0.0 0.0 0.43737868737351226 0.14579289579117072 1.1491521866112181e-10 9.93962245222664 1.5622607749527566 YLSPK(ub)YIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLSPKYIK 8 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 58470200.0 17719300.0 26246100.0 14504800.0 True False 23230173.893945307 22330284.186496522 13003982.435866298 1.0 0.9612620330972498 0.5597884241088547 24.46949661797055 -6.925620009058069 0.7819138799925978 1.0071970642572008 0.4858665250348231 0.9956049905980645 0.013193767732077685 0.09497695577541547 0.08929720725654686 0.011720459276265102 0.03723959857367498 1.186806704163591e-07 6.925620009058069 -0.5213305392223777 YLSPK(ub)YIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLSPKYIK 8 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 76873000.0 17105200.0 24520000.0 35247800.0 True False 16562204.78891309 34310963.870110765 26015343.76866608 1.0 2.0716422908306797 1.5707657344075965 23.981391403854477 -10.461897714674185 5.494024758061346 0.9990919627548609 1.821204012619136 0.7818544098210594 0.20448199789316035 0.002276529657469552 0.00022297082457118373 0.19818138211131653 0.06599628103661773 3.4522503739267726e-11 10.461897714674185 0.8221120498642751 YLSPK(ub)YIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLSPKYIK 8 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 183942100.0 24917300.0 20204800.0 138820000.0 True False 37801365.79863679 16599095.579177082 111382166.15303245 1.0 0.4391136465173882 2.946511688131892 25.17193502551828 -6.8479885278126265 1.244816406488497 0.7011402857174919 3.0428919205387825 0.9373195646909042 0.2690072196828208 0.1596834532975365 0.47718205306242695 0.16918717763373806 0.3910258658372686 1.41909500756442e-07 6.8479885278126265 2.3417516348212906 up YLSPK(ub)YIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLSPKYIK 8 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 48275400.0 17719300.0 14101300.0 16454800.0 True False 24270604.05607752 13478257.939236736 12568515.13724365 1.0 0.5553326117510327 0.5178492924281549 24.53270667949344 -13.999999999999998 0.3503616846267356 6.480623346219999 0.5126954279311351 0.9997553974309598 0.0034249249484988135 20.695922406279735 0.19056826840906008 84.43169603169225 0.0111698749177219 1.0000000000000041e-14 13.999999999999998 -5.967927918288864 YLSPK(ub)YIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLSPKYIK 8 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 70623700.0 17105200.0 35787100.0 17731400.0 True False 14223731.688844126 35594307.78911684 21438953.75926944 1.0 2.502459169490237 1.507266463419323 23.761796679288754 -10.528203600146782 5.375585464331003 0.9970763531899504 2.004862816454783 0.5761581764249872 0.40628572093556686 0.014258478111866308 0.0012514156778625776 0.39400923243838115 0.1311281525821088 2.9634417825684775e-11 10.528203600146782 1.0077864632648326 YLSPK(ub)YIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLSPKYIK 8 1 P60842;J3KT12;P60842-2;J3QS69;J3KSZ0;J3KTB5;J3QL43;J3QR64;J3QLN6;J3KS25 P60842 EIF4A1 Eukaryotic initiation factor 4A-I 1 104033300.0 24917300.0 16773000.0 62343000.0 True False 32255936.043413337 15839567.80534801 50997213.69319904 1.0 0.49105900334219105 1.5810179442494483 24.94306134761073 -6.779724662701325 1.5368498390308991 0.7117228918882437 1.589591972762654 0.7664458009631435 0.21520117862926358 0.2510023411485786 1.1709504948994651 0.11028866851405078 0.26030507011900367 1.6606393984886065e-07 6.779724662701325 0.8778690808744103 YLSQLK(ub)DAHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLSQLKDAHR 10 1 M0QXB4;O14579-2;O14579;O14579-3 M0QXB4 COPE Coatomer subunit epsilon 1 18935500.0 7519600.0 8177600.0 3238300.0 True False 9858268.419909978 6957533.956035143 2903231.7799670333 1.0 0.705756189594468 0.2944971323872255 23.232902832419033 -7.098659251638175 0.35786380132970896 1.0398919291691753 8.37362586490373e-16 0.9998969787055696 0.002936756719897343 0.07619085651873601 0.016366122225365955 0.006520885879154978 0.03522533846578107 7.967842638364496e-08 7.098659251638175 -1.0398919291691744 down YLSQLK(ub)DAHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLSQLKDAHR 10 1 M0QXB4;O14579-2;O14579;O14579-3 M0QXB4 COPE Coatomer subunit epsilon 1 22004800.0 7082800.0 8373100.0 6548900.0 True False 6857960.390928708 11716522.495139651 4833546.627211271 1.0 1.708455842153529 0.7048081866446461 22.709348141142815 -6.717061247606921 1.7701749943516767 1.4323599416286332 0.7066479052494583 0.49855883492867026 0.2982316148315769 0.3610191692114158 2.209279225675053 0.13386545019539026 0.3371832472778753 1.9183981740668368e-07 6.717061247606921 -0.7257120363791749 YLSQLK(ub)DAHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLSQLKDAHR 10 1 M0QXB4;O14579-2;O14579;O14579-3 M0QXB4 COPE Coatomer subunit epsilon 1 82218000.0 12465000.0 17968000.0 51785000.0 True False 18910316.31356561 14761470.015375236 41549672.05182818 1.0 0.7806040771928212 2.1971960364312824 24.172670159714748 -6.867348945699859 1.1479546387399364 0.8776880700347021 2.276108876958351 0.9619688297740486 0.12140760665565392 0.1394260603315648 0.3450492472382968 0.08219987063466175 0.1937750967398636 1.3572225110770962e-07 6.867348945699859 1.398420806923649 up YLSQLK(ub)DAHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLSQLKDAHR 10 1 M0QXB4;O14579-2;O14579;O14579-3 M0QXB4 COPE Coatomer subunit epsilon 1 16565800.0 7519600.0 4336100.0 4710100.0 True False 10299799.32954915 4144516.7644347907 3597671.3875544704 1.0 0.40238810794542024 0.3492952893978324 23.296112893941924 -13.999999999999998 0.34269328653914766 8.026676220622674 0.3412345727555194 0.9997405442657221 0.004752203587309816 19.95378027853352 0.18795316281060867 101.70521155204193 0.01624782934432939 1.0000000000000041e-14 13.999999999999998 -7.685441647867155 YLSQLK(ub)DAHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLSQLKDAHR 10 1 M0QXB4;O14579-2;O14579;O14579-3 M0QXB4 COPE Coatomer subunit epsilon 1 30650200.0 7082800.0 17468000.0 6099400.0 True False 5889662.021241802 17373896.416873477 7374756.339560785 1.0 2.949897015178859 1.2521527233587946 22.48975341657709 -6.612637832027157 2.1434142973442873 2.3004216873850694 1.2582926549562674 0.05869252086831611 0.8401029720071531 0.6055459744394746 5.275402463847531 0.3231876319093865 0.9325918405005742 2.439844611740054e-07 6.612637832027157 -1.042129032428802 YLSQLK(ub)DAHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLSQLKDAHR 10 1 M0QXB4;O14579-2;O14579;O14579-3 M0QXB4 COPE Coatomer subunit epsilon 1 79453300.0 12465000.0 19263000.0 47725300.0 True False 16136188.22188391 18190997.11646213 39039785.10293112 1.0 1.127341653823267 2.4193932647603438 23.943796481807198 -6.925958580797984 0.7792403937634746 0.9771331186135619 2.659272875837002 0.9956828826252888 0.04213020573794567 0.09479079911407076 0.08835983119199056 0.03749729284518182 0.11961074537490848 1.1858818417924704e-07 6.925958580797984 1.6821397572234402 up YLSYGSGPK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLSYGSGPKR 10 1 Q9UHP3;Q9UHP3-1;Q9UHP3-3 Q9UHP3 USP25 Ubiquitin carboxyl-terminal hydrolase 25 1 15850700.0 6013200.0 5111300.0 4726200.0 True False 9122464.023805263 4199148.580230818 3792064.498432948 1.0 0.4603085930811074 0.415684237124693 23.120992125599255 -13.999999999999998 0.3531810252780706 7.768712192391937 0.4097761247151247 0.9997607226882105 0.004107783346145327 20.980564754048693 0.19153817320493527 106.70235525744215 0.013171393890422056 1.0000000000000041e-14 13.999999999999998 -7.3589360676768125 YLTEHPDPNNENIVGYNNKK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLTEHPDPNNENIVGYNNKK 20 1 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 1 21247500.0 2501500.0 4945000.0 13801000.0 True False 3238241.061936825 4669806.402995641 11289359.61021831 1.0 1.442081152600351 3.4862628798444146 21.626778956421035 -6.941563076624175 0.6448571608530472 0.977530476871364 4.063823729553568 0.9983615604442703 0.04383649091055868 0.08706071214688058 0.051416085627791666 0.04319499777494417 0.17476265256369347 1.1440287098273214e-07 6.941563076624175 3.086293252682204 up YLTEK(ub)AVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLTEKAVK 8 1 Q5BJD5;E9PJ42 Q5BJD5 TMEM41B Transmembrane protein 41B 1 4168550.0 405590.0 836860.0 2926100.0 True False 337266.05568355235 832351.6690762962 3537933.981242225 1.0 2.4679378640383227 10.49003871460392 18.3635275993114 -6.9378432236598595 0.6793331145277786 0.9057121578239505 12.522648995603125 0.9978675264883812 0.19260809517174296 0.08876452023577175 0.059194827110614884 0.18455652181626403 0.6972612824276132 1.1538697190737498e-07 6.9378432236598595 11.616936837779175 YLTK(ub)K(ub)TQAASVEAVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLTKKTQAASVEAVK 15 2 A0A087WWF6;P49005;F8W8R3;C9JHC7;H7C1B3 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 2 8096010.0 1298000.0 611510.0 6186500.0 True False 1256795.700489277 855689.1319825232 4566070.05897823 1.0 0.6808498243981891 3.6331044554024454 20.26131871960313 -6.880133716198552 1.0790977743419354 0.8018669165782744 3.8428289531195574 0.9737912108139626 0.21416818524815448 0.12750964425145547 0.2715952884885894 0.15287204013040148 0.3697958217902929 1.3178509191103168e-07 6.880133716198552 3.0409620365412833 up YLTK(ub)K(ub)TQAASVEAVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLTKKTQAASVEAVK 15 2 A0A087WWF6;P49005;F8W8R3;C9JHC7;H7C1B3 A0A087WWF6 POLD2 DNA polymerase delta subunit 2 2 5663400.0 1298000.0 1452900.0 2912500.0 True False 1079344.5111498064 1445072.9393219287 3521490.284121516 1.0 1.3388430889248868 3.2626193469684073 20.041723995037405 -6.937015068664197 0.6867681729659232 0.9768900101050697 3.738812709173223 0.9977462594781888 0.04730229969713288 0.08915509194156353 0.06101031000555927 0.045063730165991064 0.16786846712370754 1.1560721293984707e-07 6.937015068664197 2.7619226990681534 up YLTPK(ub)SQFGSASHSEAVQEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLTPKSQFGSASHSEAVQEVR 21 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 40838000.0 14176000.0 14672000.0 11990000.0 True False 18584873.2805793 12482994.791008057 10749389.816201305 1.0 0.6716750016290106 0.5783945714299883 24.14762551554798 -13.999999999999998 0.1764997423526759 2.6858039037273596 0.5015564910615916 0.9995027793430253 0.004031910488124302 12.161463631667369 0.13314347119752223 7.025759816974198 0.07177508779252158 1.0000000000000041e-14 13.999999999999998 -2.184247412665768 YLTPK(ub)SQFGSASHSEAVQEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLTPKSQFGSASHSEAVQEVR 21 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 68387400.0 18288000.0 17441500.0 32657900.0 True False 17707457.45034508 24405981.9062209 24103816.274000634 1.0 1.3782883270881603 1.3612240120633978 24.07785373981847 -10.170639922771139 4.936189093703185 0.9999702129297905 1.3697561695766158 0.9984051668889182 0.006966477439708028 2.28391762475215e-06 3.8372855379948904e-07 0.006745805395510836 0.0022484209250607885 6.750875164982557e-11 10.170639922771139 0.36978595664682534 YLTPK(ub)SQFGSASHSEAVQEVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLTPKSQFGSASHSEAVQEVR 21 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 98565000.0 35143000.0 28734000.0 34688000.0 True False 53314500.297443725 23606193.200233284 27831901.595709484 1.0 0.4427724740649052 0.5220324947328436 25.668024629881675 -10.681052499000916 6.734541371672079 1.0036815189568271 0.4824024843990713 0.9827172106915766 0.03235776793981631 0.0017954713034681147 8.503335331792255e-05 0.03145047330446187 0.010443424695946073 2.0842389179463395e-11 10.681052499000916 -0.5212790345577558 YLTPK(ub)SQFGSASHSEAVQEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLTPKSQFGSASHSEAVQEVR 21 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 42166000.0 14176000.0 11405000.0 16585000.0 True False 19417250.291995455 10901089.38870848 12667964.578796811 1.0 0.56141262149782 0.6524077502373773 24.21083557707087 -9.9589472955703 5.727537110252436 1.0000004283746788 0.6069101858673391 0.9613631722386935 0.037148605749430484 2.031937075485093e-07 3.6963952142566727e-08 0.035969021975523374 0.011989660950056522 1.0991392189553879e-10 9.9589472955703 -0.3930902425073397 YLTPK(ub)SQFGSASHSEAVQEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLTPKSQFGSASHSEAVQEVR 21 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 47449000.0 18288000.0 18990000.0 10171000.0 True False 15207282.295768622 18887697.100780144 12297709.07460942 1.0 1.2420166031925104 0.8086723738949212 23.858259015252745 -6.7551430695470405 1.6308087734114445 1.141422388012894 0.807461031702195 0.6708146531169581 0.10173391324147822 0.29115091614825755 1.5249288987175094 0.04924885739041685 0.11892467052476109 1.7573445969010718e-07 6.7551430695470405 -0.333961356310699 YLTPK(ub)SQFGSASHSEAVQEVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLTPKSQFGSASHSEAVQEVR 21 1 Q8IYW5 Q8IYW5 RNF168 E3 ubiquitin-protein ligase RNF168 1 89429300.0 35143000.0 32941400.0 21344900.0 True False 45493306.272095144 31108182.13218217 17460347.217168953 1.0 0.6837969073103711 0.3838003576336866 25.439150951974124 -7.197199653804491 0.2362309581927699 1.126204292767774 1.4933758683320235e-12 0.9999744983919557 0.0012705014919816675 0.09012830273775667 0.011591571036838461 0.011992709054210024 0.038051711370134945 6.350389247217004e-08 7.197199653804491 -1.1262042927662805 down YLTTAVITNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLTTAVITNK 10 0 P60228;E5RGA2;E5RHS5 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 25417800.0 9279600.0 6109200.0 10029000.0 False True 12165645.463774221 5197731.173475091 8991295.284961056 1.0 0.42724664210809316 0.7390726050446347 23.536309530536585 -10.121463627869838 5.4183326492705675 1.000007240481875 0.5831596235762256 0.7043706727395402 0.1273024162916356 1.1134693741421974e-05 1.8053117346312906e-06 0.12326217424300966 0.04108667818571022 7.56025374755811e-11 10.121463627869838 -0.4168476169056493 YLTTAVITNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLTTAVITNK 10 0 P60228;E5RGA2;E5RHS5 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 9785300.0 3413800.0 1688600.0 4682900.0 False True 3305430.7876196457 2362866.785932669 3456308.00601134 1.0 0.7148438245274077 1.0456452511293834 21.65640687575061 -6.67864526984887 1.9067931566226985 0.819356464682298 1.0443696821223212 0.31786101651088705 0.12089246535773618 0.4415591912298968 3.1028164827736426 0.05089658143404042 0.13446520044688526 2.0958236180185111e-07 6.67864526984887 0.22501321744002323 YLTTAVITNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLTTAVITNK 10 0 P60228;E5RGA2;E5RHS5 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 19780800.0 9279600.0 3870300.0 6630900.0 False True 12710518.89176077 3699297.3486294127 5064817.987672223 1.0 0.2910421974218044 0.39847452576899484 23.599519592059476 -10.086722969544626 5.321969939042915 1.000009035835392 0.3447583616064646 0.9802367103747383 0.04385906439039113 4.702298845233396e-06 8.06897802730608e-07 0.04246694192834917 0.01415545216338233 8.189870420773304e-11 10.086722969544626 -0.6552506742289272 YLTTAVITNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLTTAVITNK 10 0 P60228;E5RGA2;E5RHS5 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 7657300.0 3413800.0 2792900.0 1450600.0 False True 2838725.9569824454 2777854.0933527546 1753913.7531834044 1.0 0.9785566255594473 0.6178524379464257 21.436812151184885 -6.919087639742843 0.8314657089705029 1.0082234711291673 0.560889083462978 0.9939236869615647 0.013665580164010857 0.09871166129565272 0.10841805951835373 0.011717752891409446 0.03479985566478214 1.2047927911051065e-07 6.919087639742843 -0.44733438766618927 YLTTAVITNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLTTAVITNK 10 0 P60228;E5RGA2;E5RHS5 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 0 14050400.0 5032700.0 6141900.0 2875800.0 False True 6514929.3593481835 5800097.865835985 2352433.908199826 1.0 0.8902779364005695 0.36108356337346165 22.635318105221103 -6.940613245857867 0.6538437262932058 1.0058831371062227 0.21576982432100464 0.9982429908484326 0.01169250903760972 0.08748825658515215 0.053346110293761205 0.011435276329485052 0.04542512909161637 1.1465335143967378e-07 6.940613245857867 -0.790113312785218 down YLTTAVITNK(ub)DVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLTTAVITNKDVR 13 1 P60228;E5RGA2;E5RHS5 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 4613300.0 1020800.0 1706400.0 1886100.0 True False 1338278.6854412607 1451811.7714951048 1690944.4647487334 1.0 1.0848351597383543 1.26352192793924 20.351947145870465 -6.9590198203180496 0.4490377642715597 0.9941807149894837 1.3612486579131764 0.9997320882922575 0.0017977397258199025 0.08005319163227813 0.022439511654975552 0.0023849368551759494 0.014782476013117026 1.0989556841827234e-07 6.9590198203180496 0.3670679429236927 YLTTAVITNK(ub)DVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLTTAVITNKDVR 13 1 P60228;E5RGA2;E5RHS5 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 15664300.0 1095900.0 2823800.0 11744600.0 True False 1061111.2543653324 3951358.0659224675 8668336.929552363 1.0 3.723792438980244 8.169112233888269 20.017144495799805 -6.963817357946143 0.3777997500341246 0.6869941093991431 11.362561099271405 0.9998866530514511 0.03145783597760851 0.07836459469449013 0.016289238863376906 0.05798941381202986 0.3760268379493928 1.0868826147728533e-07 6.963817357946143 10.675566989872262 YLTTAVITNK(ub)DVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLTTAVITNKDVR 13 1 P60228;E5RGA2;E5RHS5 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 148829200.0 3200200.0 13526000.0 132103000.0 True False 4854937.365958498 11112179.620879631 105992784.14719832 1.0 2.2888409846016176 21.83195706918712 22.21102125273302 -6.9202940735219425 0.8225501060044053 0.5733486733582499 25.004800525785754 0.9942620734184021 0.7219670321258974 0.09799899103971346 0.10472228102456976 0.6230186923954874 1.8714948446128756 1.201450621692311e-07 6.9202940735219425 24.431451852427504 up YLTTAVITNK(ub)DVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLTTAVITNKDVR 13 1 P60228;E5RGA2;E5RHS5 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 14361800.0 1020800.0 1848500.0 11492500.0 True False 1398217.3460827398 1766827.1578279382 8778208.195467148 1.0 1.2636284071127422 6.278142822401873 20.415157207393356 -6.91778410892901 0.8409939379054918 0.8802766204588396 7.046962216303826 0.9935429943574018 0.1951343793550507 0.09949329709284181 0.11249856149913387 0.16618448063847854 0.4877309656270035 1.2084143977571748e-07 6.91778410892901 6.166685595844987 up YLTTAVITNK(ub)DVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLTTAVITNKDVR 13 1 P60228;E5RGA2;E5RHS5 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 5431500.0 1095900.0 2012600.0 2323000.0 True False 911289.406601753 2001757.7243301794 2808728.559661553 1.0 2.1966213036480267 3.0821477121471785 19.79754977123408 -7.689786826864343 0.16997869009676245 1.497071779604194e-21 4.662451355332197 0.9999552331390236 0.005708524357027315 0.13735914374711514 0.021095712866252 0.19930099896124678 0.3168210000881217 2.042740376279876e-08 7.689786826864343 4.662451355332197 YLTTAVITNK(ub)DVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLTTAVITNKDVR 13 1 P60228;E5RGA2;E5RHS5 P60228 EIF3E Eukaryotic translation initiation factor 3 subunit E 1 99088600.0 3200200.0 12924400.0 82964000.0 True False 4142721.985372875 12205145.77853932 67865403.2825267 1.0 2.946165787043701 16.381838685324748 21.98214757482547 -6.932943911892593 0.7222180978543928 0.8163257361052781 19.358967726815056 0.9970858765863765 0.36916896620184303 0.09113774977579633 0.07040101676567062 0.3424262378132617 1.1966260600713954 1.1669603175004392e-07 6.932943911892593 18.54264199070978 YLTVAAIFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLTVAAIFR 9 0 Q13885;Q9BVA1 Q13885;Q9BVA1 TUBB2A;TUBB2B Tubulin beta-2A chain;Tubulin beta-2B chain 0 40568800.0 12271000.0 24911000.0 3386800.0 False True 16087399.83253302 21194375.90231749 3036366.424479614 1.0 1.317451926535499 0.18874190087196502 23.9394278298101 -6.831602746500427 1.3206504737800546 1.169452157272801 0.1573463715765718 0.9090484159992098 0.1433316411169036 0.17884908099518543 0.6094803325181514 0.08519729819164276 0.19606730389940347 1.4736598575072117e-07 6.831602746500427 -1.0121057856962292 down YLTVAAIFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLTVAAIFR 9 0 Q13885;Q9BVA1 Q13885;Q9BVA1 TUBB2A;TUBB2B Tubulin beta-2A chain;Tubulin beta-2B chain 0 57101200.0 33985000.0 16994000.0 6122200.0 False True 32906164.77744848 23779792.82253925 4518612.157936879 1.0 0.7226546449082457 0.1373181040238883 24.97185455396815 -7.256007680401559 0.5629596345928526 1.004297308233107 7.100873780819228e-27 0.9979714560993825 0.016195804202005535 0.09438532300164564 0.05458316599230416 0.016229753364548176 0.05547351969271094 5.546159046119564e-08 7.256007680401559 -1.004297308233107 down YLTVAAIFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLTVAAIFR 9 0 Q13885;Q9BVA1 Q13885;Q9BVA1 TUBB2A;TUBB2B Tubulin beta-2A chain;Tubulin beta-2B chain 0 779370000.0 214360000.0 262110000.0 302900000.0 False True 325199791.81515604 215334422.62522286 243031682.23421356 1.0 0.6621603950706685 0.7473303745912392 28.27675109293454 -9.820178094560273 6.051465227743786 1.0000000214064897 0.7047453848306277 0.9412578825186732 0.03477049853928033 1.0012751207975295e-08 1.9896075483014373e-09 0.03366639245164842 0.01122213014832606 1.5129406976945255e-10 9.820178094560273 -0.29525463657586204 YLTVAAIFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLTVAAIFR 9 0 Q13885;Q9BVA1 Q13885;Q9BVA1 TUBB2A;TUBB2B Tubulin beta-2A chain;Tubulin beta-2B chain 0 92261000.0 12271000.0 32402000.0 47588000.0 False True 16807920.31130613 30970372.500914715 36348694.50562457 1.0 1.842605862432723 2.16259321988658 24.00263789133299 -10.336271283182404 0.21616107464694886 2.1497540558174018e-19 2.3962474600370656 0.9993008246716383 0.012965830270560842 1.9565592400807574 0.10595001384054037 1.2624513505250832 0.17586484674861252 4.610295013147885e-11 10.336271283182404 2.3962474600370656 YLTVAAIFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLTVAAIFR 9 0 Q13885;Q9BVA1 Q13885;Q9BVA1 TUBB2A;TUBB2B Tubulin beta-2A chain;Tubulin beta-2B chain 0 73658000.0 33985000.0 20379000.0 19294000.0 False True 28260033.290775202 20269214.282085206 23328286.19462336 1.0 0.7172395755351638 0.82548686176666 24.752259829402426 -10.20931212257527 6.250391436696973 1.000002612384675 0.7713632187738095 0.856081046578475 0.04419176955136221 1.6087538128738931e-06 2.0356428610675091e-07 0.04278898585902391 0.01426283229265495 6.175723982489177e-11 10.20931212257527 -0.2286393936108655 YLTVAAIFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLTVAAIFR 9 0 Q13885;Q9BVA1 Q13885;Q9BVA1 TUBB2A;TUBB2B Tubulin beta-2A chain;Tubulin beta-2B chain 0 752200000.0 214360000.0 281210000.0 256630000.0 False True 277493245.66731095 265560416.29654282 209925973.24616525 1.0 0.9569977664066299 0.7565084070473099 28.04787741502699 -6.941376578984459 0.6466311730530011 1.002207860188455 0.7001808288693603 0.9983386871321046 0.004324941457315722 0.08714424353953053 0.05179185575473714 0.004255283106751795 0.017153773017405265 1.1445200917825405e-07 6.941376578984459 -0.3020270313190947 YLTVAAVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLTVAAVFR 9 0 P04350;P07437;Q5JP53;Q5ST81;P68371 P04350;P07437;P68371 TUBB4A;TUBB;TUBB4B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain 0 322316000.0 114540000.0 178516000.0 29260000.0 False True 150163049.20693794 151882108.64991805 26232455.88173901 1.0 1.0114479524227769 0.17469314868259214 27.161954610005417 -6.903798703960247 0.9369332245448053 1.0312569615831828 0.0797566375683024 0.9883634599514755 0.042262356701706555 0.10866313431604374 0.16206688462384647 0.033573131665544396 0.0891406449765769 1.2479618120845515e-07 6.903798703960247 -0.9515003240148804 down YLTVAAVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLTVAAVFR 9 0 P04350;P07437;Q5JP53;Q5ST81;P68371 P04350;P07437;P68371 TUBB4A;TUBB;TUBB4B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain 0 406901100.0 259294100.0 95660000.0 51947000.0 False True 251062950.72591475 133857536.86030985 38340522.323404506 1.0 0.533163242418998 0.15271278463249174 27.903473905399846 -7.965568731750917 0.3643062846177972 1.0767971303184205 2.1569975243239026e-20 0.9983060334565357 0.014261280713360547 0.10102634651612302 0.07357277311705054 0.047454259363847257 0.08401875494100514 1.082508383030138e-08 7.965568731750917 -1.0767971303184205 down YLTVAAVFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLTVAAVFR 9 0 P04350;P07437;Q5JP53;Q5ST81;P68371 P04350;P07437;P68371 TUBB4A;TUBB;TUBB4B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain 0 5436900000.0 1627700000.0 1876100000.0 1933100000.0 False True 2469339900.809521 1541295296.9637954 1551021937.6921728 1.0 0.6241730012375024 0.6281119651384173 31.201478288871648 -9.97233688293049 5.005314215409112 1.000002561941044 0.6261424831821191 0.9999167503369437 0.0016080753008009805 4.8180363099109736e-08 9.891939134333571e-09 0.0015570233868835548 0.0005190040684531557 1.0657690817071309e-10 9.97233688293049 -0.3738600787589249 YLTVAAVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLTVAAVFR 9 0 P04350;P07437;Q5JP53;Q5ST81;P68371 P04350;P07437;P68371 TUBB4A;TUBB;TUBB4B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain 0 604800000.0 114540000.0 225930000.0 264330000.0 False True 156888533.32711333 215947665.54939976 201900698.04723343 1.0 1.3764400811826565 1.2869053828572004 27.225164671528308 -10.07998171111828 4.324495449779909 0.9999678375884586 1.3316727320361748 0.9481779778228197 0.03655238769830809 5278111.429424121 4100923.3764062296 1528.45591504684 0.012512854692525504 8.317987988319392e-11 10.07998171111828 0.3317048944477161 YLTVAAVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLTVAAVFR 9 0 P04350;P07437;Q5JP53;Q5ST81;P68371 P04350;P07437;P68371 TUBB4A;TUBB;TUBB4B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain 0 465970100.0 259294100.0 109870000.0 96806000.0 False True 215614532.826294 109278108.5025124 117047687.01962838 1.0 0.5068216277914362 0.5428562049383089 27.683879180834122 -9.896212004113556 5.710368216468734 1.0000002364855978 0.5248389175096732 0.9957051380315733 0.014711054520680986 4.428952774873999e-08 8.586137707660345e-09 0.014243924293816304 0.0047479724298924225 1.2699540162779803e-10 9.896212004113556 -0.4751613189759246 YLTVAAVFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLTVAAVFR 9 0 P04350;P07437;Q5JP53;Q5ST81;P68371 P04350;P07437;P68371 TUBB4A;TUBB;TUBB4B Tubulin beta-4A chain;Tubulin beta chain;Tubulin beta-4B chain 0 5482800000.0 1627700000.0 2180000000.0 1675100000.0 False True 2107089736.7637691 2058681083.6259897 1370248987.9774435 1.0 0.9770258227292544 0.6503040492627417 30.972604610964098 -6.921090672309434 0.816607998932126 1.0069295052069125 0.5962744075767544 0.9944783000914775 0.011867664819254059 0.09753434796038161 0.10232372530074303 0.01028468033648531 0.03113563688752175 1.1992488969764596e-07 6.921090672309434 -0.41065509763015806 YLVLANMLMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLVLANMLMK 10 0 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 0 5816190.0 2344400.0 2997100.0 474690.0 False True 3073531.1032018973 2549944.362604296 425573.6323480065 1.0 0.8296465130767191 0.13846407212364265 21.551465654104295 -7.0526833452124285 0.6779378330959889 1.0024520255611369 2.0201301522193473e-23 0.9981986896026426 0.015810798425675655 0.07587696144009087 0.054952950262767995 0.015517540319873239 0.05021867496406797 8.857612047209977e-08 7.0526833452124285 -1.0024520255611369 down YLVLANMLMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLVLANMLMK 10 0 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 0 11400100.0 2344400.0 4326200.0 4729500.0 False True 3211188.035027803 4135054.179169717 3612489.5071100155 1.0 1.2877022877714837 1.124969783053747 21.614675715627186 -10.249291504444043 4.273836584564565 0.9998744801378225 1.206336035349761 0.6818916373452504 0.06643526688630225 8.088191361378117e-05 1.4207161115394424e-05 0.06436537639506563 0.021441890182986936 5.632594613991244e-11 10.249291504444043 0.20646155521193843 YLVPDLVQEYIEK(ub)HNLYSSESEDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLVPDLVQEYIEKHNLYSSESEDR 24 1 Q9HAN9 Q9HAN9 NMNAT1 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 1 117363500.0 56508000.0 30255400.0 30600100.0 True False 54714184.47091537 42336538.999826685 22585015.826677367 1.0 0.7737762960230483 0.41278173192333645 25.705411559624675 -6.964208806144964 0.37138503122345695 1.0273284963618219 0.1466365492727832 0.9998958892132181 0.002467460250847489 0.07823052553221055 0.015813217444055092 0.004748397741790605 0.030636397634265827 1.0859034023367286e-07 6.964208806144964 -0.8806919470890386 down YLVPDLVQEYIEK(ub)HNLYSSESEDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLVPDLVQEYIEKHNLYSSESEDR 24 1 Q9HAN9 Q9HAN9 NMNAT1 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 1 153317400.0 57761400.0 67781000.0 27775000.0 True False 87628266.72397825 55684950.97462982 22285259.075785045 1.0 0.6354679038675132 0.25431587213726087 26.384892987056745 -7.4676497802423 0.32959799493858033 1.067526557046729 1.7537975108149004e-14 0.9995917382530061 0.006151547494136823 0.12039742397115945 0.033783437737778955 0.019568811976540364 0.06301806700095688 3.4068280925252444e-08 7.4676497802423 -1.0675265570467114 down YLVPDLVQEYIEK(ub)HNLYSSESEDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLVPDLVQEYIEKHNLYSSESEDR 24 1 Q9HAN9 Q9HAN9 NMNAT1 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 1 101801200.0 56508000.0 36609000.0 8684200.0 True False 46988905.72885465 36411780.0506824 10500026.068795899 1.0 0.774901638714325 0.22345755675574522 25.48581683505895 -7.021118959138912 0.5120177959501356 1.009515629580033 1.1811995223620915e-14 0.9995431419552283 0.006972711021555893 0.07442324397575113 0.028415508858151785 0.008185895524774334 0.0413086797879502 9.525352159937597e-08 7.021118959138912 -1.0095156295800212 down YLVPDLVQEYIEK(ub)HNLYSSESEDR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLVPDLVQEYIEKHNLYSSESEDR 24 1 Q9HAN9 Q9HAN9 NMNAT1 Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 1 135719300.0 57761400.0 57335900.0 20622000.0 True False 74773270.94741479 54145106.762693256 16869007.59958856 1.0 0.724123822278304 0.22560210869271582 26.156019309149194 -7.138741167479931 0.4547251020384801 1.0166333145150357 5.862097377629904e-12 0.999593183152729 0.006463832168261272 0.08028659556311311 0.02718293864500873 0.008364880201055044 0.04194300187755026 7.265388338780282e-08 7.138741167479931 -1.0166333145091735 down YLVSLGCIKPLCDLLTVMDSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLVSLGCIKPLCDLLTVMDSK 21 1 O60684 O60684 KPNA6 Importin subunit alpha-7 0 26779000.0 14795000.0 0.0 11984000.0 False True 22445096.6593825 0.0 9615357.1472262 1.0 0.0 0.428394552856906 24.419896973417167 -10.781628518912003 6.695607116137127 1.027113394119016 0.21419727642845762 0.8177242267513174 0.17489134384786287 0.062329607769938684 0.002032824436664365 0.1491091707103439 0.05644593850988402 1.6533754360350227e-11 10.781628518912003 -0.8129161176905584 YLVVLYYNANR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLVVLYYNANR 11 0 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 0 33743100.0 10013000.0 14507000.0 9223100.0 False True 13127139.966029925 12342612.147843087 8268782.08622237 1.0 0.9402361961389138 0.6298997426415892 23.64604929207376 -6.938965486941706 0.6691215182659628 1.0035535313665422 0.5486995659036785 0.9980251876857805 0.00720912334711241 0.08824189242174035 0.056783439655938496 0.006963688871567598 0.026834104117387115 1.150891845826277e-07 6.938965486941706 -0.4548539654628637 YLVVLYYNANR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLVVLYYNANR 11 0 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 0 71377000.0 32928000.0 18810000.0 19639000.0 False True 31882718.66387594 26320931.09285415 14494956.742628854 1.0 0.825554789425048 0.4546336495153428 24.92627131849796 -6.958830072957585 0.4516246390403518 1.0117647981995053 0.2536793699044718 0.9997243021501657 0.0037759469438514524 0.08012178553278611 0.022696156969039042 0.004969884794156934 0.030674030130917032 1.099435933204313e-07 6.958830072957585 -0.7580854282950334 down YLVVLYYNANR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLVVLYYNANR 11 0 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 0 303206000.0 97473000.0 92973000.0 112760000.0 False True 147873667.23082057 76381241.74863541 90472936.57553622 1.0 0.5165303815006466 0.6118258799540978 27.139789924870044 -9.924076442809413 5.660171863655357 1.000000354320901 0.5641781307267633 0.9653831365378664 0.038904224334812096 13062456.768796396 22902624.282849237 40.213213542786 0.013317953593253945 1.19103234873887e-10 9.924076442809413 -0.4358222235941378 YLVVLYYNANR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLVVLYYNANR 11 0 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 0 70423000.0 10013000.0 18963000.0 41447000.0 False True 13715076.691150548 18125151.95774474 31658072.227759507 1.0 1.321549442697592 2.3082679696706627 23.70925935359665 -6.950941262979991 0.548415952304841 0.9862240829256468 2.6898218942255716 0.9992730737301443 0.01500772527414772 0.08311003510150317 0.03441552901737267 0.016322379398551516 0.0818324351798571 1.1195892943063647e-07 6.950941262979991 1.7035978112999248 up YLVVLYYNANR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLVVLYYNANR 11 0 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 0 71261000.0 32928000.0 14666000.0 23667000.0 False True 27381090.957735654 14586991.347026926 28615660.276155848 1.0 0.5327395964442329 1.0450883903905006 24.706676593932237 -6.666762089200774 1.9491791105098533 0.7009133708911639 1.0429745373605221 0.26460688537554633 0.1986333094352619 0.46861948607832987 3.4294021987093473 0.0821380406653074 0.22035673737437753 2.153961372863767e-07 6.666762089200774 0.34206116646935825 YLVVLYYNANR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLVVLYYNANR 11 0 Q9Y3B4 Q9Y3B4 SF3B6 Splicing factor 3B subunit 6 0 319273000.0 97473000.0 107450000.0 114350000.0 False True 126180719.98007928 101470313.04385896 93539473.3300821 1.0 0.8041665403389562 0.741313517190658 26.910916246962493 -13.999999999999998 0.15898903646018994 1.9624202045697416 0.6788314586682124 0.9995390611893822 0.0023651030205907118 12.003166656323518 0.12597173524964655 3.5626816984304788 0.05687572123777681 1.0000000000000041e-14 13.999999999999998 -1.2835887459015294 YLVVSLSNGTIHIFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLVVSLSNGTIHIFR 15 0 Q9BRZ2 Q9BRZ2 TRIM56 E3 ubiquitin-protein ligase TRIM56 0 5683700.0 2291200.0 1693300.0 1699200.0 False True 2218467.110139473 2369443.5204428458 1254128.54509267 1.0 1.068054382962604 0.5653131116349182 21.081131733980886 -6.872742620724006 1.1195377443151746 1.0392041921893511 0.5343006212666124 0.9673420258122656 0.04024415381772962 0.13424971131411415 0.31282548791876796 0.02784964846537816 0.06626513041459771 1.340470865622199e-07 6.872742620724006 -0.5049035709227387 YLVVSLSNGTIHIFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLVVSLSNGTIHIFR 15 0 Q9BRZ2 Q9BRZ2 TRIM56 E3 ubiquitin-protein ligase TRIM56 0 141264000.0 35193000.0 48564000.0 57507000.0 False True 53390353.95293329 39897374.76773615 46140716.24378654 1.0 0.7472768358664191 0.8642144662397683 25.67007577763518 -10.081765835703346 4.594552385713412 1.00001111167143 0.8057456511176644 0.786295318055508 0.04773958771377686 66866874.80130153 267326396157.99625 6632335.418233404 0.01749837777844123 8.283886966038379e-11 10.081765835703346 -0.1942654605537657 YLVVSLSNGTIHIFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLVVSLSNGTIHIFR 15 0 Q9BRZ2 Q9BRZ2 TRIM56 E3 ubiquitin-protein ligase TRIM56 0 7435000.0 2291200.0 2222600.0 2921200.0 False True 1905234.3173701388 2210626.4126484413 3532009.4138972587 1.0 1.1602910951655783 1.8538451578872535 20.861537009415162 -6.943075129194614 0.6303140113424333 0.9924344479842382 2.059100185944294 0.9985394941223529 0.01416112599056675 0.08639148481817556 0.04842991837879892 0.014130072151877534 0.058932070589267554 1.1400525512561933e-07 6.943075129194614 1.066665737960056 YLVVSLSNGTIHIFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLVVSLSNGTIHIFR 15 0 Q9BRZ2 Q9BRZ2 TRIM56 E3 ubiquitin-protein ligase TRIM56 0 111842000.0 35193000.0 40590000.0 36059000.0 False True 45558032.257742435 38331130.81852236 29496631.996584438 1.0 0.8413693243304666 0.6474518440504328 25.44120209972763 -6.968434203815782 0.2931844134775773 1.036475608766612 0.4463275588175249 0.9999674610245689 0.0008223524425991893 0.07681415255240032 0.010839270339522691 0.003331031277713944 0.01752152685520748 1.0753895109746823e-07 6.968434203815782 -0.5901480499490872 YLWESPSLAIKPWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLWESPSLAIKPWK 14 1 O95163;F5H2T0 O95163 IKBKAP Elongator complex protein 1 0 5582200.0 1044100.0 1953500.0 2584600.0 False True 1368825.211078784 1662045.4146833613 2317170.385233855 1.0 1.2142130355514769 1.6928168523486438 20.384506806125174 -6.957822652210752 0.46510871377712104 0.9867389423845871 1.939750442109486 0.9996807125783457 0.005175195461611321 0.08048833595649506 0.024076440721155664 0.0065582756115561336 0.03951736539113614 1.101989224201694e-07 6.957822652210752 0.9530114997248988 YLWESPSLAIKPWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLWESPSLAIKPWK 14 1 O95163;F5H2T0 O95163 IKBKAP Elongator complex protein 1 0 4976400.0 1044100.0 1463300.0 2469000.0 False True 1430131.9857415669 1398646.5675139967 1885873.0506511524 1.0 0.9779842570185968 1.3186706328180402 20.447716867648065 -6.891476447227959 1.0136330252869812 0.9823371253083266 1.3488318743668786 0.9818257162567718 0.0209864061372849 0.11795239643491039 0.21492798255109713 0.015744490427571086 0.03946479091054285 1.2838773961595482e-07 6.891476447227959 0.36649474905855195 YLWHIPLTYSTSSSNVIHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLWHIPLTYSTSSSNVIHR 19 0 Q6P179-3;Q6P179;D6RGW0 Q6P179-3 ERAP2 Endoplasmic reticulum aminopeptidase 2 0 7864600.0 2849100.0 3447800.0 1567700.0 False True 3735197.6907236474 2933401.679419139 1405489.442440265 1.0 0.7853404082745696 0.3762824778808345 21.832753171074696 -6.960979222914498 0.42140603989748593 1.0178097474425665 0.12834679661991322 0.9998048099847808 0.0036146023800455993 0.07935316527793027 0.019852429258559918 0.0052964198512483575 0.0340378540109738 1.0940087034985779e-07 6.960979222914498 -0.8894629508226533 down YLWHIPLTYSTSSSNVIHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLWHIPLTYSTSSSNVIHR 19 0 Q6P179-3;Q6P179;D6RGW0 Q6P179-3 ERAP2 Endoplasmic reticulum aminopeptidase 2 0 14409700.0 4350100.0 3402800.0 6656800.0 False True 4212008.456624357 4761555.785367575 4913184.380280658 1.0 1.1304715634839069 1.1664706827816405 22.00607690224948 -13.999999995484703 0.1806723358791986 0.3216413045359921 1.1948690399544777 0.9994973365643173 0.0016033966820948404 12.213612127546556 0.13475260547822962 2.9089421526481725 0.02672561960632762 1.0000000103968546e-14 13.999999995484703 0.8732277354184856 YLWHIPLTYSTSSSNVIHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLWHIPLTYSTSSSNVIHR 19 0 Q6P179-3;Q6P179;D6RGW0 Q6P179-3 ERAP2 Endoplasmic reticulum aminopeptidase 2 0 24670500.0 2849100.0 10304400.0 11517000.0 False True 3902489.2640324626 9849117.535905968 8796921.800060475 1.0 2.5238038773561735 2.254182191130635 21.895963232597587 -10.08999264935433 4.505781697287866 0.999895026869395 2.388993034300703 0.9725167639252146 0.11007259273289861 19136029.893927697 5.052930082525211 21889.811639888034 0.03768077621271117 8.128442738329763e-11 10.08999264935433 1.3890980074313077 YLWHIPLTYSTSSSNVIHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLWHIPLTYSTSSSNVIHR 19 0 Q6P179-3;Q6P179;D6RGW0 Q6P179-3 ERAP2 Endoplasmic reticulum aminopeptidase 2 0 20820200.0 4350100.0 9219400.0 7250700.0 False True 3617300.8921053796 9169733.262292374 8766787.846551033 1.0 2.5349655822950656 2.4235716375389758 21.786482177683755 -10.141642862828324 4.609480115753529 0.9998380426643397 2.479268609880765 0.9957650602127629 0.045476387604330114 7.641041225520648e-05 1.4228836826543485e-05 0.04403705218900828 0.014677440973710437 7.21700717677898e-11 10.141642862828324 1.4794305672164252 YLWHIPLTYSTSSSNVIHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLWHIPLTYSTSSSNVIHR 19 0 Q6P179-3;Q6P179;D6RGW0 Q6P179-3 ERAP2 Endoplasmic reticulum aminopeptidase 2 0 32687800.0 5365800.0 15830000.0 11492000.0 False True 6946133.875730808 14949046.584311629 9400573.917877594 1.0 2.152139139808737 1.3533534029227954 22.72777878597445 -10.167025414621145 4.821898278244628 0.9999275347334675 1.7527462713689372 0.542138063468875 0.3261029115415282 0.00025406535496116364 4.3889747514551275e-05 0.3157779733139784 0.10524926212762017 6.807295216941172e-11 10.167025414621145 0.7528187366354697 YLYFHLQQQHLIELIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLYFHLQQQHLIELIR 16 0 Q9NWU2 Q9NWU2 GID8 Glucose-induced degradation protein 8 homolog 0 69962000.0 12749000.0 23399000.0 33814000.0 False True 19341165.0767467 19223265.632778566 27130648.078797296 1.0 0.99390422223789 1.4027411467272806 24.205171366979652 -6.903517255109016 0.9387686658939418 0.9846029315655688 1.4488565742217798 0.9882361093316849 0.020749434868937676 0.10886270480566536 0.1631807114883139 0.01646109574279265 0.043636268246903975 1.2487708282454048e-07 6.903517255109016 0.46425364265621105 YLYFHLQQQHLIELIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLYFHLQQQHLIELIR 16 0 Q9NWU2 Q9NWU2 GID8 Glucose-induced degradation protein 8 homolog 0 52739000.0 12749000.0 23251000.0 16739000.0 False True 16503831.820360823 21957061.410728343 13692673.756644016 1.0 1.3304220286370014 0.8296663408646304 23.9762976890721 -6.728764792433841 1.7278079246230778 1.1991230337630152 0.8300360184357722 0.5534662904555646 0.13891589395026746 0.33857422173239815 1.9796008201779356 0.06372968897856567 0.15835805760620425 1.8673907686603182e-07 6.728764792433841 -0.369087015327243 YLYLQVLGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLYLQVLGGK 10 0 Q8TAP6 Q8TAP6 CEP76 Centrosomal protein of 76 kDa 0 25605200.0 5678500.0 9504700.0 10422000.0 False True 8614699.653957663 7808512.024439955 8362087.131875121 1.0 0.9064172098968838 0.9706765723438205 23.038369068003156 -10.06904497287133 4.719911169751583 1.0000024803832837 0.9385468911190982 0.5494320010644436 0.026233774869562767 36410014.264879026 3.188795424802892 981.4935932627952 0.008980518914710212 8.530117767790702e-11 10.06904497287133 -0.061455589264185484 YLYLQVLGGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLYLQVLGGK 10 0 Q8TAP6 Q8TAP6 CEP76 Centrosomal protein of 76 kDa 0 21835900.0 5678500.0 8990300.0 7167100.0 False True 7350930.189969332 8489981.901891153 5862761.340656157 1.0 1.1549534116751792 0.7975536686032133 22.809495390095606 -6.7888523747297445 1.5007567817677772 1.0867311851188977 0.7938628559895804 0.7976509833010639 0.06582692422918293 0.23705585396818593 1.0547610639767875 0.0345262139736522 0.0809079156896576 1.626101405794699e-07 6.7888523747297445 -0.29286832912931726 YLYLYKNEIQSIDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLYLYKNEIQSIDR 14 1 H7C300;H7C1W1;Q92626-2;Q92626 H7C300 PXDN Peroxidasin homolog 0 71165000.0 24092000.0 22004000.0 25069000.0 False True 31584845.307259917 18721088.9709202 22475100.358828258 1.0 0.5927237822063063 0.7115786112038439 24.912729170575954 -10.474472900436698 9.052343248432962 1.0000060832942232 0.6521511967050766 0.9194881097620727 0.04852228075161951 5.957293575003126e-06 3.4586206247764036e-07 0.04698231746258285 0.01566049877258525 3.3537223070641994e-11 10.474472900436698 -0.34785488658914665 YLYLYKNEIQSIDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLYLYKNEIQSIDR 14 1 H7C300;H7C1W1;Q92626-2;Q92626 H7C300 PXDN Peroxidasin homolog 0 88026000.0 26670000.0 30809000.0 30547000.0 False True 25823375.44841989 43111194.3668125 22545824.30964326 1.0 1.6694639495492614 0.8730781285613388 24.62217425604228 -6.683798367594654 1.8885176494727045 1.4221319392688474 0.8760243855416079 0.34150832089159877 0.28350333688163076 0.4301558252812963 2.969333382795483 0.12031799819003838 0.31578024297183005 2.0711026884075254e-07 6.683798367594654 -0.5461075537272395 YLYLYKNEIQSIDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLYLYKNEIQSIDR 14 1 H7C300;H7C1W1;Q92626-2;Q92626 H7C300 PXDN Peroxidasin homolog 0 66974000.0 24092000.0 24462000.0 18420000.0 False True 32999463.461819597 23381187.954983488 14069575.371808095 1.0 0.7085323669591034 0.42635770087857955 24.975939232098845 -6.985042136288602 0.22012061622124374 1.130710745213443 5.190431549375495e-11 0.9999920363759724 0.0006608811122763278 0.07431064459995905 0.007226637318569593 0.007787771445683211 0.02814572389991209 1.0350417395842513e-07 6.985042136288602 -1.1307107451615388 down YLYLYKNEIQSIDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLYLYKNEIQSIDR 14 1 H7C300;H7C1W1;Q92626-2;Q92626 H7C300 PXDN Peroxidasin homolog 0 78424000.0 26670000.0 33549000.0 18205000.0 False True 22177286.681329228 33368264.87804493 22011581.329590455 1.0 1.5046143992960708 0.992528150349507 24.402579531476555 -10.60083881235731 3.666773797439033 0.9914529320656704 1.2485712748322357 0.23905911459641782 0.20905833573299176 152738846.15390506 86581.42699200551 11021480.74268912 0.07156622493836094 2.5070395637597756e-11 10.60083881235731 0.2571183427665653 YLYSSEDYIK(ub)SGALLACGIVNSGVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLYSSEDYIKSGALLACGIVNSGVR 25 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 21706200.0 15271000.0 3571200.0 2864000.0 True False 14786230.463922774 4997198.783561976 2113832.4818416946 1.0 0.33796299846365463 0.142959524876829 23.817750969241278 -12.809045114209779 0.1903767334828845 3.2092949615719695 3.5474902019770735e-19 0.9994437775178296 0.008650593193959206 7.664890741583332 0.13071059578773517 6.512237658060099 0.13220057542538108 1.5522257574469627e-13 12.809045114209779 -3.2092949615719695 YLYSSEDYIK(ub)SGALLACGIVNSGVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLYSSEDYIKSGALLACGIVNSGVR 25 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 372878800.0 91708800.0 141510000.0 139660000.0 True False 139128954.41135356 116256434.87732351 112056139.78484759 1.0 0.8356020166269319 0.8054120744236923 27.05184745244204 -13.999999999999998 0.23834774775315754 2.0795111059125273 0.7918526809450471 0.9995222565158843 0.0018689408441442284 13.565606991435107 0.1545270196509517 6.9634406556801185 0.014896487781083465 1.0000000000000041e-14 13.999999999999998 -1.2876584249674803 YLYSSEDYIK(ub)SGALLACGIVNSGVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLYSSEDYIKSGALLACGIVNSGVR 25 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 29896600.0 15271000.0 2711600.0 11914000.0 True False 12698513.120006707 2696992.0725895413 14405162.315887963 1.0 0.21238644612182098 1.1343975613327835 23.598156244675554 -6.680583423923704 1.900783689497657 0.5019026196008497 1.130822773187056 0.32641991134747306 0.333770632940035 0.4371979128012924 3.0547467639811168 0.14090639405184563 0.37122176195692214 2.086491289880131e-07 6.680583423923704 0.6289201535862062 YLYSSEDYIK(ub)SGALLACGIVNSGVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLYSSEDYIKSGALLACGIVNSGVR 25 1 Q13200;Q13200-3;Q13200-2 Q13200 PSMD2 26S proteasome non-ATPase regulatory subunit 2 1 245198800.0 91708800.0 85321000.0 68169000.0 True False 118718849.4507103 80572811.34681326 55762941.47300717 1.0 0.6786859181975604 0.4697058784768533 26.82297377453449 -8.500205623464394 0.13046016040006625 1.4716532400874451 5.550306974371476e-06 0.999941838997515 0.0016633303325005021 0.15190939111677063 0.031954174287836305 0.17650037662056942 0.15540176343137352 3.1607807851066724e-09 8.500205623464394 -1.4716476897804707 YLYTLVITDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLYTLVITDK 10 0 P63173;J3KT73;J3QL01 P63173 RPL38 60S ribosomal protein L38 0 56447000.0 15768000.0 20872000.0 19807000.0 False True 20672000.697529238 17757978.958418768 17757561.64216006 1.0 0.8590353308444518 0.8590151433326182 24.301174688036447 YLYTLVITDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLYTLVITDK 10 0 P63173;J3KT73;J3QL01 P63173 RPL38 60S ribosomal protein L38 0 77262000.0 30715000.0 19199000.0 27348000.0 False True 29739969.137541007 26865260.821462356 20184738.37758612 1.0 0.9033385575222442 0.678707441969291 24.825899814455276 -6.957007429159686 0.47573893535315454 1.005614025245072 0.5671336995614839 0.9996425947991412 0.002544449276793789 0.08078799747088347 0.025216701870829777 0.003140374852136388 0.018533545000837492 1.1040597333940475e-07 6.957007429159686 -0.4384803256835882 YLYTLVITDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLYTLVITDK 10 0 P63173;J3KT73;J3QL01 P63173 RPL38 60S ribosomal protein L38 0 123125000.0 38882000.0 41733000.0 42510000.0 False True 58986836.65495854 34285420.08858272 34107879.86720511 1.0 0.5812384937530062 0.5782286659431828 25.813889706628196 YLYTLVITDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLYTLVITDK 10 0 P63173;J3KT73;J3QL01 P63173 RPL38 60S ribosomal protein L38 0 64515000.0 15768000.0 19791000.0 28956000.0 False True 21597855.71417779 18916568.17991489 22117189.16753941 1.0 0.8758539935747981 1.0240456025002846 24.36438474955934 -6.684499596012005 1.886056897734971 0.9217694065259076 1.023500555634304 0.34473696295710177 0.05256530541376198 0.4286193953519777 2.9516099611123447 0.02233303158320753 0.058561143222035233 2.067761305384716e-07 6.684499596012005 0.10173114910839642 YLYTLVITDK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLYTLVITDK 10 0 P63173;J3KT73;J3QL01 P63173 RPL38 60S ribosomal protein L38 0 62932000.0 30715000.0 13153000.0 19064000.0 False True 25540883.405212928 13082142.1783339 23050194.258023225 1.0 0.5122039817802002 0.9024822631357633 24.606305089889553 -9.91987618480048 6.723587363885309 1.0000000159974918 0.7073431224579785 0.42848468867256184 0.1593304411685979 3.823686221860765e-08 5.9833106668114015e-09 0.15427104434331068 0.051423678765819505 1.202607243099893e-10 9.91987618480048 -0.2926568935395133 YLYTLVITDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLYTLVITDK 10 0 P63173;J3KT73;J3QL01 P63173 RPL38 60S ribosomal protein L38 0 104723000.0 38882000.0 41682000.0 24159000.0 False True 50333515.478803866 39362360.058577254 19762309.892273314 1.0 0.782030813547154 0.3926272525231323 25.585016028720645 -6.962190934229779 0.4033699636369992 1.020626367143359 0.13973534392102102 0.9998430238863164 0.0031476546129136735 0.07892756221246831 0.018306315349093306 0.005009491435636806 0.03258559355299014 1.090960598560932e-07 6.962190934229779 -0.880891023222338 down YLYTLVITDK(ub)EK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLYTLVITDKEK 12 1 P63173;J3KT73;J3QL01 P63173 RPL38 60S ribosomal protein L38 1 5509800.0 2383100.0 1131500.0 1995200.0 True False 2307449.794942988 1583313.8506945514 1472597.2652830142 1.0 0.6861747779581361 0.6381925485487752 21.137867827650375 -13.999999999999998 0.2643971316167976 3.350990293298115 0.6213801769116649 0.9995714291989217 0.0033215899615108013 14.616132880070712 0.162735805726906 18.40815016560561 0.020502456185928723 1.0000000000000041e-14 13.999999999999998 -2.72961011638645 YLYTLVITDKEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YLYTLVITDKEK 12 1 P63173;J3KT73;J3QL01 P63173 RPL38 60S ribosomal protein L38 0 41271700.0 13778500.0 12855300.0 14637900.0 False True 18063746.93118381 10937339.349566933 13123310.524651634 1.0 0.6054856387899004 0.7264999102703658 24.10659384376084 -10.649647342291708 9.782829037718706 1.0001248290624247 0.6659927745301337 0.9103723920639764 0.04940386945362981 0.00013455569227693916 4.818805754544822e-06 0.04785259030774015 0.015945030302676116 2.2405397730052738e-11 10.649647342291708 -0.334132054532291 YLYTLVITDKEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YLYTLVITDKEK 12 1 P63173;J3KT73;J3QL01 P63173 RPL38 60S ribosomal protein L38 0 32286600.0 12658100.0 6838000.0 12790500.0 False True 12256275.544193638 9568449.059698923 9440284.343224918 1.0 0.7806979392064939 0.7702408704165611 23.547017301457565 YLYTLVITDKEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YLYTLVITDKEK 12 1 P63173;J3KT73;J3QL01 P63173 RPL38 60S ribosomal protein L38 0 193268000.0 36486000.0 73884000.0 82898000.0 False True 55351929.48389527 60698822.94167326 66513173.96451594 1.0 1.0965981404376097 1.2016414709421837 25.722130272245096 -6.970052486201444 0.2569294199450874 0.9693811358463355 1.3319625376344166 0.999982784396501 0.00034160976130538276 0.07628567746966969 0.008969186562703032 0.002237068878738733 0.009957350043828804 1.0713898157272055e-07 6.970052486201444 0.3625814017880812 YLYTLVITDKEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YLYTLVITDKEK 12 1 P63173;J3KT73;J3QL01 P63173 RPL38 60S ribosomal protein L38 0 37674400.0 13778500.0 10646400.0 13249500.0 False True 18872783.79996185 10176006.845063213 10120240.982018001 1.0 0.5391894991709587 0.5362346694205472 24.169803905283732 YLYTLVITDKEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YLYTLVITDKEK 12 1 P63173;J3KT73;J3QL01 P63173 RPL38 60S ribosomal protein L38 0 24868600.0 12658100.0 6133700.0 6076800.0 False True 10525770.998910159 6100656.540655872 7347430.78405137 1.0 0.5795923682253333 0.6980420517235388 23.32742257689184 -10.366732776372604 8.616062122749153 1.0000012631569313 0.6388172099744388 0.9253577617298578 0.04835688079412804 1.1734027914790229e-06 8.615884649678499e-08 0.0468215124261099 0.015607116165849602 4.298008040645102e-11 10.366732776372604 -0.36118405318249247 YLYTLVITDKEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YLYTLVITDKEK 12 1 P63173;J3KT73;J3QL01 P63173 RPL38 60S ribosomal protein L38 0 167063000.0 36486000.0 72439000.0 58138000.0 False True 47231846.24658292 68407705.9710013 47557480.54625549 1.0 1.4483385979422811 1.006894380075099 25.493256594337545 -10.607015984267088 2.9857517581604616 0.9847562460828753 1.227616488748558 0.2617105066340564 0.18021884948769987 44262269.35444333 46338441.41258315 5279381.621115172 0.06595334295470008 2.4716331745490964e-11 10.607015984267088 0.24286024266568285 YMACCLLYR ddPTM_RPMI8226_Bortezomib_1h_R1 2 YMACCLLYR 9 0 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;Q9BQE3;F5H5D3;A0A1W2PQM2 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 236189900.0 102439400.0 100122000.0 33628500.0 False True 134299045.4245606 85184187.87249929 30148945.407349933 1.0 0.6342873666987421 0.22449113701471102 27.000873809462565 -7.469290894864216 0.36439999249174715 1.0503636686388262 7.951547651670054e-15 0.9993536086286112 0.008053646613007613 0.11893173531525711 0.039365767486860936 0.018505358023162843 0.0637265373099205 3.393978642948287e-08 7.469290894864216 -1.0503636686388182 down YMACCLLYR ddPTM_RPMI8226_Bortezomib_8h_R1 2 YMACCLLYR 9 0 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;Q9BQE3;F5H5D3;A0A1W2PQM2 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 355271300.0 101383000.0 194647000.0 59241300.0 False True 153805423.09010997 159910722.0660474 47532231.08861575 1.0 1.0396949525788861 0.30904132073917867 27.196531131886765 -6.894061744880249 0.9980757307356397 1.0355223413437602 0.24096793714613796 0.9833722467012432 0.04325825725862942 0.11590828824785962 0.20310647226598755 0.032836109034567997 0.0831507427968095 1.2762573467795418e-07 6.894061744880249 -0.7945544041976222 down YMACCLLYR ddPTM_RPMI8226_Carfilzomib_1h_R1 2 YMACCLLYR 9 0 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;Q9BQE3;F5H5D3;A0A1W2PQM2 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 261017400.0 102439400.0 81750000.0 76828000.0 False True 140314014.5006938 78138014.68890122 58682808.72232751 1.0 0.5568796172424734 0.41822485751797334 27.064083870985456 -13.999999999999998 0.16265630070507295 3.195003636333007 0.28583783192270884 0.9995296346326058 0.005381061457389173 12.028453654085862 0.12753571905846464 8.328483846919191 0.12107410321453158 1.0000000000000041e-14 13.999999999999998 -2.909165804410298 YMACCLLYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YMACCLLYR 9 0 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;Q9BQE3;F5H5D3;A0A1W2PQM2 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 36674260.0 13603000.0 438260.0 22633000.0 False True 11311497.215077672 435899.0063922015 27365455.656831715 1.0 0.0385359248297537 2.41926025675495 23.431286564521457 -6.797088617390887 1.4678006557338474 0.46753420978314797 2.449793990046872 0.8234888803733615 0.41084651788650245 0.2249506216066483 0.9570822064236947 0.22023388130854565 0.513110953532631 1.5955535427805568e-07 6.797088617390887 1.9822597802637243 YMACCLLYR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 YMACCLLYR 9 0 A6NHL2-2;A6NHL2;P68363;P68363-2;P68366-2;P68366;Q71U36;Q71U36-2;Q9BQE3;F5H5D3;A0A1W2PQM2 A6NHL2-2;P68363;P68366-2;Q71U36;Q9BQE3 TUBAL3;TUBA1B;TUBA4A;TUBA1A;TUBA1C Tubulin alpha chain-like 3;Tubulin alpha-1B chain;Tubulin alpha-4A chain;Tubulin alpha-1A chain;Tubulin alpha-1C chain 0 353947000.0 101383000.0 124823000.0 127741000.0 False True 131242292.05770198 117876490.32176453 104493448.7333453 1.0 0.8981593392923903 0.7961873196134347 26.967657453979214 -6.971109306382569 0.23015509427834405 1.0413911827788662 0.6500412900341991 0.9999897844117525 0.00026587954638174666 0.07594436750491874 0.007729992317962866 0.002617138138678445 0.010124797027547656 1.0687858456007223e-07 6.971109306382569 -0.39134989274466714 YMAQGK(ub)HIGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YMAQGKHIGK 10 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 3851700.0 1054400.0 1386700.0 1410600.0 True False 1382328.6108241233 1179809.7653142638 1264644.6434306577 1.0 0.8534944267780721 0.9148654187781702 20.398669187113647 -10.331133823330006 4.933899342032 1.000058031431936 0.8841799227799567 0.8260494126735839 0.025054602568260538 1.6001544432240492e-05 2.169272152522846e-06 0.02427115919459363 0.008086338207705265 4.6651560622966e-11 10.331133823330006 -0.11587810865197934 YMAQGK(ub)HIGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YMAQGKHIGK 10 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 4455100.0 712600.0 1023200.0 2719300.0 True False 689978.9030575192 1431769.0959175113 2007033.7527486477 1.0 2.0750911217326795 2.9088335075968748 19.39619272484993 -7.286830887321276 0.15434775747321383 9.955101793788643e-12 4.745268580049602 0.999993829364096 0.0019409284908588015 0.10828775788270963 0.008999012771097072 0.0866646708479259 0.17469613606013348 5.1661749906966205e-08 7.286830887321276 4.745268580039648 YMAQGK(ub)HIGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YMAQGKHIGK 10 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 8553890.0 609490.0 1896000.0 6048400.0 True False 924640.8896875321 1557643.9864843867 4852931.088892106 1.0 1.6845934501239375 5.248449579741253 19.818533637621787 -6.9389094331181616 0.6696313506435171 0.9591434277484265 6.179443477867745 0.9980175556900045 0.0829257047595505 0.0882676749247421 0.05690164236789548 0.08007001184103915 0.30823701689728383 1.151040399525541e-07 6.9389094331181616 5.220300050119318 YMAQGK(ub)HIGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YMAQGKHIGK 10 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 4001620.0 1054400.0 734320.0 2212900.0 True False 1444240.1740885978 701875.3143284882 1690258.5961060885 1.0 0.48598240578054386 1.1703445357852222 20.46187924863654 -6.705715719201128 1.810347594183413 0.6826208182792373 1.1685508770037223 0.4447813737675079 0.216755109228239 0.3837597282598838 2.4489031377942454 0.09537651631437653 0.24358007270441637 1.9691748518383037e-07 6.705715719201128 0.485930058724485 YMAQGK(ub)HIGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YMAQGKHIGK 10 1 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 1 6491690.0 609490.0 1382800.0 4499400.0 True False 788996.8198440442 1305845.9644211093 3680555.3677426465 1.0 1.6550712646461962 4.664854502797816 19.589659959714236 -6.941707631265317 0.6434802712468 0.9669597919750266 5.518966570285588 0.9983791320479231 0.06424673709293549 0.08699614864871011 0.05112617934233598 0.06338038640337815 0.257159871728173 1.143647983967049e-07 6.941707631265317 4.552006778310561 YMEAFKPFLGIGLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 YMEAFKPFLGIGLK 14 1 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 0 60737600.0 13810000.0 20426700.0 26500900.0 False True 18105043.73623022 17379115.98265297 23758841.08258292 1.0 0.95990466722129 1.3122774752009474 24.10988832613837 -6.878607502104623 1.0875737857432766 0.9755809390036404 1.336588844990564 0.9725430783123874 0.026100012021388126 0.12886894745520794 0.2798216110862932 0.018509533611214053 0.044605304814555095 1.32249030783623e-07 6.878607502104623 0.36100790598692367 YMEAFKPFLGIGLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 YMEAFKPFLGIGLK 14 1 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 0 67179900.0 20707100.0 16881200.0 29591600.0 False True 20049764.44499348 23621951.194295026 21840672.231028873 1.0 1.178166020807967 1.0893231334936002 24.2570819514635 -10.122536870579193 5.27526507331026 0.9999968564144746 1.1337445771508827 0.7513465301227564 0.03626995686631075 1.3409739186365999e-06 2.2310966288961523e-07 0.03511906046675306 0.011706078242523546 7.541593667746876e-11 10.122536870579193 0.13374772073640817 YMEAFKPFLGIGLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YMEAFKPFLGIGLK 14 1 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 0 28954700.0 8947700.0 8858000.0 11149000.0 False True 13574315.064491834 7277220.692130102 8945395.263219703 1.0 0.536102238496446 0.6589942270177137 23.69437606828237 -10.23194440892995 8.124307575592711 1.0000002316295595 0.5975482327570913 0.9346381636613847 0.050170444225512215 2.1050188219827155e-07 1.9868848815058385e-08 0.048577351968882264 0.016192441246436415 5.862131968587628e-11 10.23194440892995 -0.4024519988724682 YMEAFKPFLGIGLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 YMEAFKPFLGIGLK 14 1 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 0 83156300.0 13810000.0 26486900.0 42859400.0 False True 18915930.201217316 25316621.17753466 32736892.437050663 1.0 1.3383756922461805 1.730652000129706 24.173098387661263 -6.969185306064452 0.27695536752955696 0.9103497058437975 2.1705819895652403 0.9999753115166996 0.0014834483291895598 0.07656795886934943 0.009972732902469512 0.0073752878120205605 0.03614651197569728 1.0735312570870029e-07 6.969185306064452 1.2602322837214428 YMEAFKPFLGIGLK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 YMEAFKPFLGIGLK 14 1 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 0 58492900.0 20707100.0 15169100.0 22616700.0 False True 17218871.130069476 15087381.047469398 27345747.40219438 1.0 0.8762119731021254 1.5881266080469263 24.037487226897778 -6.862056251816028 1.1753993524502997 0.9324430722112036 1.6239637320235527 0.9560857218790486 0.06508054694840452 0.14469289556784765 0.37870602758551525 0.0431498479912773 0.10096263957777976 1.3738640143102734e-07 6.862056251816028 0.6915206598123491 YMEAFKPFLGIGLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YMEAFKPFLGIGLK 14 1 Q14974;Q14974-2;J3KTM9 Q14974 KPNB1 Importin subunit beta-1 0 24182100.0 8947700.0 9337300.0 5897100.0 False True 11582974.035535531 8817671.046853637 4823888.309355731 1.0 0.7612614014157166 0.41646370738261795 23.46550239037482 -6.965879127913301 0.34263072222993673 1.0362767389271377 0.12994397022471016 0.9999301351327913 0.0020021557847964408 0.07766390680377816 0.01381514709234608 0.004829160311188095 0.029787003972141648 1.0817349760073602e-07 6.965879127913301 -0.9063327687024275 down YMEENDQLK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 YMEENDQLKK 10 1 P51572-2;P51572;C9JSP1;C9JQ75;C9J0M4;C9JMD7;A0A2R8Y5M6 P51572-2 BCAP31 B-cell receptor-associated protein 31 1 3330270.0 853790.0 422080.0 2054400.0 True False 826686.9037910175 590618.7451181217 1516291.0093210817 1.0 0.7144406696291724 1.834178093747077 19.656981506523536 -6.839064923561206 1.2866548573487033 0.8480615609180678 1.870347753749602 0.9228459526302635 0.13195790766449128 0.16989419262063515 0.5467359058349328 0.08042999747648685 0.18525910840316076 1.4485552898954197e-07 6.839064923561206 1.022286192831534 YMFSRPFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YMFSRPFR 8 1 P46778;G3V1B3;M0R181;M0R3I5 P46778 RPL21 60S ribosomal protein L21 0 8867900.0 2598500.0 1657600.0 4611800.0 False True 3406658.663909792 1410292.541274193 4134615.175509363 1.0 0.4139811705278429 1.2136863664421553 21.69992597066086 -6.710252008766785 1.7943236521487953 0.6398457052321065 1.2118301362044592 0.4664881662582765 0.24693110089558365 0.3744660671647891 2.35033110180397 0.10951055923848654 0.2781215261529397 1.9487134884621116e-07 6.710252008766785 0.5719844309723527 YMFSRPFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YMFSRPFR 8 1 P46778;G3V1B3;M0R181;M0R3I5 P46778 RPL21 60S ribosomal protein L21 0 22359500.0 7272200.0 7247800.0 7839500.0 False True 11032459.069034241 5954373.462680131 6290019.388825086 1.0 0.5397140769271275 0.5701375685571161 23.395251059065806 -9.935152761393445 5.15690282914696 1.0000013659962426 0.5549258227368279 0.9965078298997062 0.012420338467003017 17009038.434658773 2.822696557265536 289.99579792849875 0.004251812215975945 1.1610401506534391e-10 9.935152761393445 -0.4450755432594147 YMFSRPFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YMFSRPFR 8 1 P46778;G3V1B3;M0R181;M0R3I5 P46778 RPL21 60S ribosomal protein L21 0 9857400.0 2598500.0 2957300.0 4301600.0 False True 3559235.6718221 2826636.7075166674 3285650.674232887 1.0 0.7941695825018552 0.923133778480829 21.763136032183752 -10.383472675546042 5.354809300757899 1.0000706157480366 0.85865168052802 0.6156362273369452 0.052649412539472626 4.440792263437489e-05 5.112857143453676e-06 0.05100300425093358 0.01699252482941366 4.135493327629903e-11 10.383472675546042 -0.14141893522001658 YMFSRPFR ddPTM_RPMI8226_Carfilzomib_8h_R1 2 YMFSRPFR 8 1 P46778;G3V1B3;M0R181;M0R3I5 P46778 RPL21 60S ribosomal protein L21 0 61198200.0 9188000.0 12451900.0 39558300.0 False True 11894047.122556703 11758940.818900207 32359095.3024345 1.0 0.9886408467812212 2.7206126702715383 23.503736360806258 -6.905423885353428 0.9263522711598335 0.9383096734937498 2.923831943584731 0.98907662897707 0.08505374799430085 0.10752191443933609 0.15576414186546186 0.06809599708506801 0.18251438975774315 1.2433005181599771e-07 6.905423885353428 1.9855222700909811 up YMGK(ub)GVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YMGKGVSK 8 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8 P06733 ENO1 Alpha-enolase;Enolase 1 29186500.0 9086700.0 11593000.0 8506800.0 True False 8798247.68230811 16222145.356696337 6278613.881470294 1.0 1.8437927576551996 0.7136209513737147 23.06878478491728 -6.70683227718412 1.8063844776767795 1.5204134148785164 0.716504740255793 0.4500865265331684 0.3557509893063012 0.38148437597867624 2.4244593841988817 0.1568385221664518 0.39999834147277435 1.964118665264569e-07 6.70683227718412 -0.8039086746227234 YMGK(ub)GVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YMGKGVSK 8 1 P06733;K7EM90;A0A2R8YEM5;A0A2R8Y879;K7ERS8 P06733 ENO1 Alpha-enolase;Enolase 1 23998800.0 9086700.0 11210000.0 3702100.0 True False 7555993.659063911 11149609.504989205 4476191.993423607 1.0 1.4755980494523728 0.5924028255442116 22.849190060351557 -6.76044072397202 1.6107994521178999 1.2761019295661176 0.5891041897299075 0.6927727059894699 0.20005050462898813 0.2821758468390168 1.4431037244081155 0.09798456485924752 0.2353710753767188 1.7360381952538743e-07 6.76044072397202 -0.68699773983621 YMHSGPVVAMVWEGLNVVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YMHSGPVVAMVWEGLNVVK 19 0 Q32Q12;P22392-2;J3KPD9;E7ERL0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 5735660.0 3769700.0 1180380.0 785580.0 False True 4942113.205826733 1004271.9050852031 704295.7174154657 1.0 0.20320698115558547 0.1425090215629022 22.23669662726207 -13.771023714942011 0.36721627884253855 9.996867374276519 0.1358673125276071 0.999780257563773 0.005791696688388849 18.924779948985346 0.1960314147796718 132.91547319151832 0.017120684030042795 1.69424528251924e-14 13.771023714942011 -9.861000061748912 YMHSGPVVAMVWEGLNVVK ddPTM_RPMI8226_Bortezomib_2h_R1 3 YMHSGPVVAMVWEGLNVVK 19 0 Q32Q12;P22392-2;J3KPD9;E7ERL0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 134318600.0 42810900.0 40447400.0 51060300.0 False True 41451891.41300191 56598257.750404485 37686075.65383431 1.0 1.3653962659144603 0.9091521368314113 25.304934596328277 -6.69344681148731 1.853884455284624 1.2283404916841698 0.9106507568151073 0.38660845205548977 0.15443155241045994 0.4093715413395851 2.730384198749245 0.06656995951089699 0.1726215216080362 2.02559766876138e-07 6.69344681148731 -0.3176897348690625 YMHSGPVVAMVWEGLNVVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YMHSGPVVAMVWEGLNVVK 19 0 Q32Q12;P22392-2;J3KPD9;E7ERL0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 43652900.0 6452900.0 20170000.0 17030000.0 False True 9789521.070181092 16570505.91107069 13664013.035485836 1.0 1.6926778942786584 1.395779521544364 23.222806850340483 -10.107775398221484 4.522171934296498 0.999954780291877 1.5442287079273678 0.8175209893604167 0.121208253210146 84436371.92854007 4.360657871452619 44164.789504259286 0.041492809009113146 7.80233515438333e-11 10.107775398221484 0.5442739276354908 YMHSGPVVAMVWEGLNVVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YMHSGPVVAMVWEGLNVVK 19 0 Q32Q12;P22392-2;J3KPD9;E7ERL0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 14302300.0 3769700.0 2271900.0 8260700.0 False True 5163459.962312024 2171519.9458313696 6309692.794456848 1.0 0.4205552016828336 1.2219892940995285 22.29990668878496 -6.712720355796231 1.7852920661885754 0.6447709811734963 1.2202800756697316 0.478119002103638 0.2440731025903565 0.3696297869385833 2.2981131455524904 0.10872222791886699 0.2753205401834537 1.937669236427343e-07 6.712720355796231 0.5755090944962353 YMHSGPVVAMVWEGLNVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 3 YMHSGPVVAMVWEGLNVVK 19 0 Q32Q12;P22392-2;J3KPD9;E7ERL0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 88149800.0 42810900.0 17982000.0 27356900.0 False True 35599160.19444016 17885127.39685245 33077101.305985894 1.0 0.5024030707231607 0.9291539779399582 25.085339871762553 -10.165860918327153 7.7355183366969325 1.0000001002671635 0.7157785243315599 0.37163445602555856 0.1742203283251602 3.0141470237805114e-07 3.2494919770574014e-08 0.16868816787057345 0.05622936918117781 6.825572463187622e-11 10.165860918327153 -0.2842215759356036 YMHSGPVVAMVWEGLNVVK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 YMHSGPVVAMVWEGLNVVK 19 0 Q32Q12;P22392-2;J3KPD9;E7ERL0;P15531;P15531-2 Q32Q12;P15531 NME1-NME2;NME2;NME1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Nucleoside diphosphate kinase A 0 32077100.0 11897100.0 6799000.0 13381000.0 False True 15401030.47690131 6420629.673198661 10945795.300654396 1.0 0.41689610853172554 0.7107183715447521 23.876523548519902 -10.521694133592641 6.392374522249069 1.0003820922408069 0.5638072400382569 0.746096468307063 0.11995243657529164 0.00065374413787408 4.891580415279308e-05 0.11624149257113263 0.038714482432758816 3.008194178062331e-11 10.521694133592641 -0.43657485220255 YMK(ub)NSQVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YMKNSQVR 8 1 K7EP06;O43148;O43148-2;K7ERH6 K7EP06 RNMT mRNA cap guanine-N7 methyltransferase 1 1428100.0 221210.0 497020.0 709870.0 True False 290008.45220068697 422866.5533687859 636419.4619538644 1.0 1.4581180312502084 2.194485909374323 18.145735422160882 -6.964083127537288 0.37345979984164146 0.9455478968995585 2.7328276057491427 0.9998929713897174 0.005090350574791825 0.07827355330455005 0.01596591693473271 0.009657846013356687 0.062425312273127594 1.0862176927138813e-07 6.964083127537288 1.7872797088495842 YMK(ub)NSQVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YMKNSQVR 8 1 K7EP06;O43148;O43148-2;K7ERH6 K7EP06 RNMT mRNA cap guanine-N7 methyltransferase 1 1523580.0 415870.0 773430.0 334280.0 True False 402668.43448572897 1082264.632384168 246722.03981495876 1.0 2.6877314924533144 0.6127176075523816 18.619232857086033 -6.69038233271917 1.8649180300256105 2.0577023119488502 0.6198248284660262 0.3723074318962202 0.713733082940805 0.4158312985221008 2.804244958131587 0.306124266142655 0.7968258483303154 2.0399412842437024e-07 6.69038233271917 -1.437877483482824 YMK(ub)NSQVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YMKNSQVR 8 1 K7EP06;O43148;O43148-2;K7ERH6 K7EP06 RNMT mRNA cap guanine-N7 methyltransferase 1 1492310.0 221210.0 522220.0 748880.0 True False 302997.31497547304 499146.5936493948 572009.9676677341 1.0 1.6473630919462094 1.8878384044889542 18.208945483683774 -10.828193538285332 0.198423510930027 1.4085596132742187e-09 2.0842937714341043 0.9993891121105745 0.009266866297709963 2.7766037745326364 0.10745003295409374 1.4507837268411323 0.15096614523924812 1.4852735998750785e-11 10.828193538285332 2.084293770025545 YMK(ub)NSQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YMKNSQVR 8 1 K7EP06;O43148;O43148-2;K7ERH6 K7EP06 RNMT mRNA cap guanine-N7 methyltransferase 1 1398440.0 415870.0 618580.0 363990.0 True False 345814.33116476925 615247.586761484 440098.6261003917 1.0 1.7791269224997464 1.2726442672808116 18.39963813252031 -10.332653006153976 6.13084040214481 0.9999573933332483 1.5258855948902688 0.5897348308538026 0.20677067814272937 0.00012043122784723525 1.3109254939491426e-05 0.2002209964422533 0.06673494941090026 4.6488656327120876e-11 10.332653006153976 0.5259282015570205 YMNSGPVVAMVWEGLNVVK ddPTM_RPMI8226_Bortezomib_2h_R1 2 YMNSGPVVAMVWEGLNVVK 19 0 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 23536300.0 9240500.0 4118000.0 10177800.0 False True 8947165.385493979 5762338.875086312 7511928.852544826 1.0 0.6440407242755097 0.8395875709108833 23.09299925370873 -10.102064381809761 5.086969111066122 1.0000069849240378 0.7418141475925821 0.6991895368195834 0.07983166584662713 6.324255427508401e-06 1.1163291052091814e-06 0.07729876812722754 0.025765559360025354 7.905614228542427e-11 10.102064381809761 -0.2581928373314557 YMNSGPVVAMVWEGLNVVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YMNSGPVVAMVWEGLNVVK 19 0 Q32Q12;P22392-2;P22392;O60361 Q32Q12 NME1-NME2;NME2;NME2P1 Nucleoside diphosphate kinase;Nucleoside diphosphate kinase B;Putative nucleoside diphosphate kinase 0 13086300.0 7259000.0 1471900.0 4355400.0 False True 6036180.128225317 1463970.5825507257 5266094.0029057 1.0 0.24253262020879157 0.8724216128477219 22.5252044279091 -10.51309081013068 8.675975843457978 1.0000263951032022 0.5574771165291191 0.3968947059909059 0.25715110442684813 0.00013129807451713355 7.3686439788158945e-06 0.24900026913952794 0.08299516207533557 3.068380328955369e-11 10.51309081013068 -0.4425492785740831 YMPAVTSTPTVNQHETSTSK(ub)SVFEPEDSSIVDNELWSEMR ddPTM_RPMI8226_Bortezomib_2h_R1 2 YMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMR 40 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 74318500.0 31526900.0 24021000.0 18770600.0 True False 30526095.8164526 33612710.56786013 13854016.754070414 1.0 1.101113970485015 0.45384175026416373 24.863539749779193 -6.866977348080709 1.1499009270329161 1.0562685754573982 0.41803957034092654 0.9615756819662937 0.05573020283695734 0.1397895391578461 0.34734934306346643 0.03767640964528321 0.08876558208130386 1.3583842953090916e-07 6.866977348080709 -0.6382290051164716 down YMPAVTSTPTVNQHETSTSK(ub)SVFEPEDSSIVDNELWSEMR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YMPAVTSTPTVNQHETSTSKSVFEPEDSSIVDNELWSEMR 40 1 A0A5H1ZRS1;Q15154-5;Q15154;A0A4W8VX11;Q15154-4;Q15154-2 A0A5H1ZRS1 PCM1 Pericentriolar material 1 protein 1 105447000.0 29473000.0 55290000.0 20684000.0 True False 44712695.7649193 45423067.51725822 16595798.333880728 1.0 1.0158874731256142 0.3711652372993682 25.414181193975732 -6.901253383095865 0.9533384871483 1.0258911618651683 0.301748362188104 0.9871788220086681 0.033997536455656945 0.1104876697877191 0.17227434907233946 0.02668275326149248 0.06986865531010535 1.255297364155247e-07 6.901253383095865 -0.7241427996770642 down YMPQNPCIIATK(ub)TPSSDVLVFDYTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YMPQNPCIIATKTPSSDVLVFDYTK 25 1 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 80536700.0 8616700.0 26277000.0 45643000.0 True False 13072163.865150481 21587664.0468619 36621641.04396244 1.0 1.651422386496636 2.8014980091852504 23.639994637718896 -6.962408655945738 0.40004291291649335 0.9368087982274816 3.5581081375142443 0.9998493640746935 0.00914110087855934 0.07885166822697484 0.018032603053809694 0.014797953293263718 0.09635594627790785 1.090413812233096e-07 6.962408655945738 2.6212993392867627 YMPQNPCIIATK(ub)TPSSDVLVFDYTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YMPQNPCIIATKTPSSDVLVFDYTK 25 1 Q09028-3;Q09028;Q09028-2;Q09028-4 Q09028-3 RBBP4 Histone-binding protein RBBP4 1 75685700.0 8616700.0 22012000.0 45057000.0 True False 11154488.010550104 20787012.8498969 36857088.323861085 1.0 1.8635559812549165 3.3042384633881023 23.411120959811345 -6.9634297395945675 0.384049289296622 0.9054358234509583 4.313633999193435 0.9998770283076123 0.010540183146962834 0.07849793029972846 0.016764259699959396 0.018678382346073594 0.12150583749131379 1.0878531168844198e-07 6.9634297395945675 3.4081981757424766 YMPQNPHIIATK(ub)TPSSDVLVFDYTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YMPQNPHIIATKTPSSDVLVFDYTK 25 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 22334600.0 4624500.0 4622100.0 13088000.0 True False 4477697.778823322 6467728.633933073 9659860.168416226 1.0 1.444431704283692 2.157327413677014 22.094325726432324 -6.964118916474075 0.3728704967256767 0.9469311250242465 2.6797549118186956 0.9998938069031629 0.004912344408439928 0.07826129909646777 0.015922423222515882 0.009357507143686777 0.06045393596200915 1.0861281843820103e-07 6.964118916474075 1.7328237867944492 YMPQNPHIIATK(ub)TPSSDVLVFDYTK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YMPQNPHIIATKTPSSDVLVFDYTK 25 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 101651000.0 10888000.0 21361000.0 69402000.0 True False 16517892.01942257 17548962.655745227 55684664.28002282 1.0 1.0624214418589413 3.3711725572818847 23.97752624883988 -6.912694927604192 0.8771759071610746 0.9344641256494719 3.6874068079366005 0.9918995652140276 0.09930532705149027 0.10266297770683147 0.12929814532187847 0.08240179358705521 0.23194814430139218 1.2226582211444753e-07 6.912694927604192 2.7529426822871286 up YMPQNPHIIATK(ub)TPSSDVLVFDYTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YMPQNPHIIATKTPSSDVLVFDYTK 25 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 12945400.0 1175800.0 2566100.0 9203500.0 True False 1610525.0348002424 2452721.217042072 7029822.852032347 1.0 1.5229326859524972 4.364926157701283 20.619099656186748 -6.937963701923249 0.6782410665219946 0.9666969986595642 5.087496383352193 0.9978848649605043 0.06799615305537748 0.08870797401247024 0.058932509298006364 0.06520941496579173 0.24687948361764656 1.1535496667931868e-07 6.937963701923249 4.12079938469263 up YMPQNPHIIATK(ub)TPSSDVLVFDYTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YMPQNPHIIATKTPSSDVLVFDYTK 25 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 17576700.0 4624500.0 5275300.0 7676900.0 True False 3845476.650086509 5246880.911834937 9282104.296024889 1.0 1.364429273473004 2.4137721121817437 21.8747310018666 -6.952369646101903 0.5321988936154132 0.983707165515829 2.8423093811549847 0.9993743325089677 0.014991045129261579 0.08254804523244036 0.032131377648349196 0.016671020522000958 0.08680027618940735 1.1159130434410677e-07 6.952369646101903 1.8586022156391557 up YMPQNPHIIATK(ub)TPSSDVLVFDYTK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YMPQNPHIIATKTPSSDVLVFDYTK 25 1 Q16576;E9PC52;Q16576-2;Q5JP01 Q16576;Q5JP01 RBBP7 Histone-binding protein RBBP7 1 151942000.0 10888000.0 20094000.0 120960000.0 True False 14094730.634566544 18975751.235954408 98946521.15440959 1.0 1.3463010913750584 7.02010728120967 23.74865257093233 -6.919384086712743 0.8292802650750176 0.8720097522609196 7.922227115966739 0.9940081317885183 0.21363642333740088 0.09853564261008435 0.10750164489057586 0.18347162804476574 0.5463916617236566 1.2039706869381183e-07 6.919384086712743 7.050217363705819 up YMQAVIQYGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YMQAVIQYGK 10 0 Q13451 Q13451 FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5;Peptidyl-prolyl cis-trans isomerase FKBP5, N-terminally processed 0 19533100.0 6354000.0 5609100.0 7570000.0 False True 8330155.53222352 4772244.144100556 6786729.016567469 1.0 0.5728877600952462 0.8147181634621805 22.98991200170645 -10.163714110847318 5.4082418798295295 1.0000091868075007 0.6938029617786428 0.6812812912730358 0.09872684875698567 1.093630693959573e-05 1.691009352905252e-06 0.09559472784962358 0.03186395342157607 6.859396210103353e-11 10.163714110847318 -0.30620622502885797 YMQAVIQYGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YMQAVIQYGK 10 0 Q13451 Q13451 FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5;Peptidyl-prolyl cis-trans isomerase FKBP5, N-terminally processed 0 9526200.0 2579500.0 1731100.0 5215600.0 False True 2497615.1844469137 2422337.2575672446 3849477.8953538863 1.0 0.9698600779862174 1.5412614078122435 21.252119782756665 -6.894452107394606 0.995661153963402 0.9724925532788352 1.5949196614465562 0.9835980221136051 0.033624270916121184 0.11560695336981726 0.20133831236682798 0.025568712861995888 0.06485527842215946 1.2751107073181907e-07 6.894452107394606 0.622427108167721 YMQAVIQYGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YMQAVIQYGK 10 0 Q13451 Q13451 FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5;Peptidyl-prolyl cis-trans isomerase FKBP5, N-terminally processed 0 20564000.0 3490400.0 7589800.0 9483800.0 False True 5295191.98242033 6235340.890621943 7609322.773102797 1.0 1.1775476529128392 1.4370249083253677 22.336251560825023 -6.965686447052595 0.3460717172653766 0.9737637005430718 1.6495119955497846 0.9999266003756387 0.0015374590238841422 0.07772881799935996 0.01404308483356587 0.0035989145240047367 0.022362123714920048 1.0822150094365842e-07 6.965686447052595 0.6757482950067127 YMQAVIQYGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YMQAVIQYGK 10 0 Q13451 Q13451 FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5;Peptidyl-prolyl cis-trans isomerase FKBP5, N-terminally processed 0 13003800.0 6354000.0 2714100.0 3935700.0 False True 8703245.510393541 2594182.087671523 3006168.7182858367 1.0 0.2980706547429362 0.3454077808899941 23.053122063229342 -9.945643248075758 7.125526484093911 1.000000020823309 0.3217392178164642 0.9963601121829401 0.019325300825012392 6.405976848748208e-09 9.391313174520278e-10 0.01871164262157684 0.006237214021309559 1.1333309575635303e-10 9.945643248075758 -0.6782608030068449 YMQAVIQYGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YMQAVIQYGK 10 0 Q13451 Q13451 FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5;Peptidyl-prolyl cis-trans isomerase FKBP5, N-terminally processed 0 7242700.0 2579500.0 2584800.0 2078400.0 False True 2144968.5412256774 2570875.1693573683 2512983.8305641715 1.0 1.1985607807041867 1.1715714157412318 21.03252505819094 -10.074238266184912 4.516162434405592 0.9999880000443128 1.1850660981873133 0.9842992594062935 0.01101836213986018 1.3537980439196773e-06 2.775249484164169e-07 0.01066918657814952 0.003556161084532272 8.428722074588499e-11 10.074238266184912 0.18507809814300058 YMQAVIQYGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YMQAVIQYGK 10 0 Q13451 Q13451 FKBP5 Peptidyl-prolyl cis-trans isomerase FKBP5;Peptidyl-prolyl cis-trans isomerase FKBP5, N-terminally processed 0 24860300.0 3490400.0 11724000.0 9645900.0 False True 4518391.6060700845 11071549.093775718 7890445.175291992 1.0 2.450329687869907 1.7462951118915484 22.107377882917472 -10.348315668692 7.201299403532696 0.9999777283759012 2.0983123998807276 0.7644236943136723 0.2874209120706155 0.00010277598265993128 9.301012283804786e-06 0.27829970724321396 0.09276470048343675 4.484193360516147e-11 10.348315668692 1.0983346715048263 YMTISDEWDIPEK(ub)QPFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YMTISDEWDIPEKQPFK 17 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 23704900.0 8334900.0 8772000.0 6598000.0 True False 8070313.161793599 12274705.345375696 4869785.864242839 1.0 1.5209701407234717 0.6034196897460353 22.944193226495223 -6.752696480614758 1.640058235164022 1.3053400841388947 0.6012350774828978 0.6604324566412549 0.2189493374834036 0.29535628251381607 1.5638960896248093 0.10542888025978553 0.2552130487618943 1.7672724992017778e-07 6.752696480614758 -0.7041050066559968 YMTISDEWDIPEK(ub)QPFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YMTISDEWDIPEKQPFK 17 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 40483000.0 10650000.0 13512000.0 16321000.0 True False 16156828.619291918 11100678.030262155 13095147.196251584 1.0 0.6870579797453251 0.8105023272089078 23.945640707336448 -10.033889500058555 5.704495117414935 1.0000007742485515 0.7487801537455643 0.8466751324537342 0.050395943819691 4.962476196236902e-07 8.41260934291898e-08 0.04879581256266227 0.016265220927468335 9.24933479930886e-11 10.033889500058555 -0.2512206205029872 YMTISDEWDIPEK(ub)QPFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YMTISDEWDIPEKQPFK 17 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 23909200.0 8334900.0 10183000.0 5391300.0 True False 6930838.648676838 10128142.157832766 6518595.903445272 1.0 1.4613155306632803 0.9405205104132287 22.7245985019295 -6.673036568942911 1.9276968589677224 1.2937001923966616 0.942644775221052 0.29217122831241427 0.19582339783908803 0.45413535000824934 3.256636668719093 0.08171831967287028 0.21738372858477908 2.1230656857553495e-07 6.673036568942911 -0.3510554171756096 YMTISDEWDIPEK(ub)QPFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YMTISDEWDIPEKQPFK 17 1 P55884;P55884-2;C9JZG1 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 39248000.0 10650000.0 11185000.0 17413000.0 True False 13786634.94288517 10562544.917594805 14244012.672468022 1.0 0.7661438024110291 1.0331754435710863 23.716767029428897 -6.675311140631932 1.918294692703741 0.8514215622535564 1.0321316563222214 0.30292398785648134 0.09921639370330147 0.44901619523507763 3.190280628881815 0.04156213444225033 0.11029038924292456 2.111975419838307e-07 6.675311140631932 0.180710094068665 YMVADK(ub)FTELQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YMVADKFTELQK 12 1 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 75794600.0 13774600.0 30423200.0 31596800.0 True False 18058633.993416145 25884177.1487048 28327466.233907364 1.0 1.43334081404727 1.5686383723284414 24.106185431589648 -11.88559016048853 0.19711694259452894 7.745686623671386e-16 1.670006170454231 0.9994085763366842 0.005898423743399977 4.975510245718366 0.12261941474233781 2.1390819411942097 0.08730846409944296 1.3013971146330876e-12 11.88559016048853 1.6700061704542304 YMVADK(ub)FTELQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YMVADKFTELQK 12 1 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 96626900.0 19772500.0 23440400.0 53414000.0 True False 19144832.81041932 32800273.960071187 39423271.01434784 1.0 1.7132703265092017 2.0592120811257355 24.19045172556795 -10.011664179725173 0.16995512980171848 9.671193724480958e-13 2.4761954872262093 0.9996131447078804 0.008673945138742138 1.5671389184912685 0.07890728180240776 0.9669907175920796 0.2580984386134333 9.734996960857068e-11 10.011664179725173 2.476195487225242 YMVADK(ub)FTELQK ddPTM_RPMI8226_Bortezomib_8h_R1 2 YMVADKFTELQK 12 1 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 392473200.0 55577000.0 70152200.0 266744000.0 True False 84314372.22294714 57632991.80835968 214021931.48195145 1.0 0.6835488456934059 2.538380181685121 26.329275238053285 -6.862960596044855 1.1706068118623367 0.8267471052455693 2.6334483962548965 0.9571431089686235 0.16771744215578877 0.1437875484263612 0.37272494732716227 0.11160001759358357 0.2614527000588541 1.371006153225955e-07 6.862960596044855 1.8067012910093272 up YMVADK(ub)FTELQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YMVADKFTELQK 12 1 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 65372600.0 13774600.0 24966500.0 26631500.0 True False 18867441.864568304 23863397.476825118 20341688.192959137 1.0 1.264792421151638 1.0781370542425976 24.16939549311254 -10.405611940667011 3.866047400706497 0.9991365414502029 1.1714647377076188 0.5294432503684673 0.07620173448176364 0.0005699436159134571 8.762633303155239e-05 0.07414918205674059 0.02459400404521977 3.929959360051166e-11 10.405611940667011 0.1723281962574159 YMVADK(ub)FTELQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YMVADKFTELQK 12 1 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 75732800.0 19772500.0 29856300.0 26104000.0 True False 16441709.820269331 29695458.18588848 31562225.708740935 1.0 1.8061052354348168 1.9196437629516512 23.970857001002226 -11.080410460731805 0.35627195045196197 6.015813777472566e-13 1.9371694409944695 0.9994131920823545 0.009917240865593677 2.981178990399369 0.17832035689054787 2.448041848948244 0.033082683652954435 8.309780252641033e-12 11.080410460731805 1.937169440993868 YMVADK(ub)FTELQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YMVADKFTELQK 12 1 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 230621000.0 55577000.0 48064000.0 126980000.0 True False 71945522.08645344 45389196.14834833 103870942.92482571 1.0 0.6308828518028731 1.443744376474314 26.100401560145734 -6.783236073637009 1.523085028150823 0.7918717211130869 1.4508681258034795 0.7787091899609933 0.15632623443987723 0.24559090581175552 1.1254445366991879 0.0808201069555502 0.19020649145765087 1.6472667274647308e-07 6.783236073637009 0.6589964046903926 YMVADKFTELQK(ub)AVGPEITK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YMVADKFTELQKAVGPEITK 20 2 P30153;B3KQV6;C9J9C1 P30153 PPP2R1A Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform 1 37653200.0 6134600.0 24045400.0 7473200.0 True False 7941360.631044439 22707252.352394655 6113154.281507391 1.0 2.8593654673768696 0.7697867614284878 22.92095478166567 -6.671977956390591 1.9303677653180227 2.1847931713538613 0.7781541463433091 0.28786410111048444 0.7894578601336032 0.45657393159578985 3.281890842746002 0.3290222160992983 0.8768018552019089 2.1282470672872245e-07 6.671977956390591 -1.406639025010552 YMVALQIAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YMVALQIAR 9 0 Q7KZ85;Q7KZ85-3 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 28921600.0 5901600.0 12064000.0 10956000.0 False True 8953158.664752413 9911084.943537787 8790541.79781462 1.0 1.1069931087624554 0.9818369278344193 23.09396532276576 -6.68035355994006 1.9001774017033626 1.0676772863551784 0.9823085615353846 0.3256844005452433 0.045343413245805535 0.4378917780970512 3.057053111950515 0.019143300170574768 0.05047471123913226 2.087595923179024e-07 6.68035355994006 -0.08536872481979385 YMVALQIAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YMVALQIAR 9 0 Q7KZ85;Q7KZ85-3 Q7KZ85 SUPT6H Transcription elongation factor SPT6 0 19382600.0 5901600.0 13481000.0 0.0 False True 7639737.537927805 12730770.499248583 0.0 1.0 1.666388463745793 0.0 22.86509164485821 -6.811791680020089 1.4974941128971644 1.3676754432929716 3.617891015856754e-20 0.8262728147031279 0.2854410354417982 0.2152636674780685 0.9653643499823757 0.15191834114422142 0.3372168480497682 1.5424401447045783e-07 6.811791680020089 -1.3676754432929716 YMVK(ub)SCGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YMVKSCGK 8 1 F8W7C6;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 17057300.0 3006300.0 4192200.0 9858800.0 True False 3941288.4130506134 3566740.1010676133 8838705.948287372 1.0 0.9049680528979369 2.242593036079308 21.9102358952661 -6.889841689955902 1.0233386831845988 0.9278546043968459 2.3572764986257426 0.9807960536010812 0.08444954107710467 0.1192708899949581 0.22260853801337316 0.06289267634009266 0.15670045557890083 1.2887192330435003e-07 6.889841689955902 1.4294218942288968 up YMVK(ub)SCGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YMVKSCGK 8 1 F8W7C6;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 8649600.0 3143800.0 2521300.0 2984500.0 True False 3044001.789829116 3528068.238405808 2202769.916919185 1.0 1.1590230499187277 0.723642779803636 21.537537776449742 -6.807855725819571 1.4234116583091276 1.086891172576139 0.7163865409600881 0.8541650766105439 0.06869392622978325 0.20975183209843457 0.8379711637915332 0.037950260236127305 0.087879831319545 1.556482614820915e-07 6.807855725819571 -0.37050463161605085 YMVK(ub)SCGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YMVKSCGK 8 1 F8W7C6;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 26353600.0 3006300.0 2448300.0 20899000.0 True False 4117810.3522027284 2340126.0105545796 15963086.628415713 1.0 0.5682937800432657 3.876595875736877 21.973445956788993 -6.8740776718724295 1.1123628801713195 0.74868031112575 4.08591803702524 0.9685830638621287 0.26027298064499443 0.1330020652010715 0.3051279537931368 0.18110840280356322 0.43206713009226755 1.3363564930317585e-07 6.8740776718724295 3.3372377258994903 up YMVK(ub)SCGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YMVKSCGK 8 1 F8W7C6;P27635;X1WI28;A0A087WV22;A6QRI9;B8A6G2 F8W7C6;P27635 RPL10 60S ribosomal protein L10 1 12435600.0 3143800.0 1111000.0 8180800.0 True False 2614208.9939543637 1105014.8224837675 9891367.45625453 1.0 0.42269567010106374 3.783694218453601 21.31794305188402 -6.862635457812745 1.1722480789956995 0.6842735785320194 3.9549139415712187 0.956769908708402 0.30509311339992684 0.1441172153485213 0.3748146489259988 0.2027539095678045 0.47481430302519884 1.3720329528758171e-07 6.862635457812745 3.2706403630391994 up YNACILEYK(ub)QSGESIDIITR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YNACILEYKQSGESIDIITR 20 1 Q16531;F5GY55;F5H2L3;F5GYG8;F5GWI0;F5GZY8 Q16531;F5GZY8 DDB1 DNA damage-binding protein 1 1 46184800.0 6543800.0 17795000.0 21846000.0 True False 9927423.015861243 14619343.217030395 17528128.524558038 1.0 1.4726221692852997 1.7656272424931418 23.24298783745711 -9.186425818985505 0.1072124566052195 2.3440268857052946e-15 2.565958505212979 0.999945544762508 0.0023275976365332548 0.6479792662931135 0.037808193199545204 0.5331460386746337 0.3422061839026637 6.509897956734242e-10 9.186425818985505 2.565958505212977 YNACILEYK(ub)QSGESIDIITR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNACILEYKQSGESIDIITR 20 1 Q16531;F5GY55;F5H2L3;F5GYG8;F5GWI0;F5GZY8 Q16531;F5GZY8 DDB1 DNA damage-binding protein 1 1 35536800.0 6543800.0 16627000.0 12366000.0 True False 8471078.097582327 15701692.833692323 10115514.885874914 1.0 1.853564877199472 1.1941236722586603 23.01411415954956 -10.241505623140755 4.835147980258395 0.9998873492310715 1.5238442747298373 0.45692835363648554 0.26921574458162234 0.00032701997572397607 5.130042660615989e-05 0.2607226658812413 0.08688900794134576 5.7344844162505703e-11 10.241505623140755 0.5239569254987658 YNATK(ub)SQVFDHETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNATKSQVFDHETK 14 1 Q9Y4C8 Q9Y4C8 RBM19 Probable RNA-binding protein 19 1 2298370.0 643040.0 779760.0 875570.0 True False 880789.2655025928 745307.6248785029 668778.3989301866 1.0 0.8461815488330438 0.7592944477457622 19.748437360799873 -13.999999930530887 0.0663357829877783 1.9188698208492934 0.4187007652403954 0.9999362973346358 0.0007943345541737511 12.3983878453809 0.06825873332498743 1.8054010764500499 0.31561907597325634 1.0000001599585572e-14 13.999999930530887 -1.500169055608898 YNATK(ub)SQVFDHETK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNATKSQVFDHETK 14 1 Q9Y4C8 Q9Y4C8 RBM19 Probable RNA-binding protein 19 1 11754600.0 1738900.0 2208900.0 7806800.0 True False 2251040.3288434763 2085972.773220847 6386042.504532449 1.0 0.926670547165436 2.836929406686119 21.102160473162577 -6.8979732104782165 0.9740015323411024 0.9161016052032799 3.0293840839778046 0.9855304127027564 0.10630327904259555 0.11291225301419963 0.18595730898689167 0.08215890937073676 0.21166837203225097 1.264814365333138e-07 6.8979732104782165 2.113282478774525 up YNCTGLNFGK(ub)VDVGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNCTGLNFGKVDVGR 15 1 Q9Y320-2;Q9Y320 Q9Y320-2 TMX2 Thioredoxin-related transmembrane protein 2 1 16808500.0 2876700.0 4213500.0 9718300.0 True False 3771381.558002429 3584862.224094359 8712743.540516192 1.0 0.9505434995002566 2.3102259494345705 21.846661687449156 -6.898459360066627 0.9709680770921978 0.9410549337127952 2.4485591206946844 0.9857837591482268 0.07507164043162778 0.11254781500636682 0.18388984170879855 0.058152259755215284 0.1501640779023791 1.2633993232741182e-07 6.898459360066627 1.507504186981889 up YNCTGLNFGK(ub)VDVGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YNCTGLNFGKVDVGR 15 1 Q9Y320-2;Q9Y320 Q9Y320-2 TMX2 Thioredoxin-related transmembrane protein 2 1 63583000.0 3240000.0 22357000.0 37986000.0 True False 4915316.875728243 18367218.67396173 30478050.450144783 1.0 3.7367313518806413 6.200627796886283 22.22885299510787 -7.406224377073776 0.24846082510828382 3.111942273656368e-15 8.935357370398021 0.9999012876494634 0.021104010854328795 0.12622115206585122 0.02166295826561826 0.17930438962165268 0.4808194959783792 3.924421288460325e-08 7.406224377073776 8.935357370398018 YNCTGLNFGK(ub)VDVGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNCTGLNFGKVDVGR 15 1 Q9Y320-2;Q9Y320 Q9Y320-2 TMX2 Thioredoxin-related transmembrane protein 2 1 19464900.0 2876700.0 3288200.0 13300000.0 True False 3940293.729894419 3142916.451376693 10158813.922098158 1.0 0.7976350665260957 2.578186962313179 21.909871748972048 -6.878644545143916 1.0873826671495568 0.8767044019420338 2.701113380918404 0.972573259576564 0.13181932869180146 0.12883510328546174 0.2796278233462067 0.09349762270965242 0.2253333564091822 1.3223775111664966e-07 6.878644545143916 1.82440897897637 up YNCTGLNFGK(ub)VDVGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNCTGLNFGKVDVGR 15 1 Q9Y320-2;Q9Y320 Q9Y320-2 TMX2 Thioredoxin-related transmembrane protein 2 1 51040000.0 3240000.0 15909000.0 31891000.0 True False 4194243.869948162 15023650.164865056 26087165.22929296 1.0 3.5819686767643146 6.219754033905372 21.99997931720032 -6.970858161799374 0.23679388726734363 0.014376326892128125 9.863339734673431 0.9999883240458184 0.007281632298652822 0.07602520934151136 0.0080270282195731 0.06451001747829947 0.25864994160778554 1.0694040837156452e-07 6.970858161799374 9.848963407781303 YNDIAVTK(ub)SSWEELVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNDIAVTKSSWEELVR 16 1 Q9UHP3;Q9UHP3-1;Q9UHP3-3;H7C253 Q9UHP3 USP25 Ubiquitin carboxyl-terminal hydrolase 25 1 6575500.0 1868300.0 2773500.0 1933700.0 True False 2449359.392642938 2359704.6110183243 1733619.2733601748 1.0 0.9633966408139586 0.7077847695880772 21.22397304430517 -6.932714913542814 0.7241584672074283 1.0035225699948997 0.6514862907172334 0.997045461485015 0.007065467169097524 0.09125247793787909 0.07095202706895891 0.006544252746037078 0.022793037250036254 1.167575804145156e-07 6.932714913542814 -0.35203627927766634 YNDIAVTK(ub)SSWEELVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YNDIAVTKSSWEELVR 16 1 Q9UHP3;Q9UHP3-1;Q9UHP3-3;H7C253 Q9UHP3 USP25 Ubiquitin carboxyl-terminal hydrolase 25 1 8436400.0 2905100.0 3340400.0 2190900.0 True False 2415719.3677513893 3322404.6021825173 2649007.0604229467 1.0 1.3753272199308038 1.0965706926830276 21.204021436955294 -10.47070063868998 5.614644657203148 0.999748237991224 1.2359489563069153 0.48856089196894614 0.11380187570454911 0.0003590230381780418 3.3845346824810244e-05 0.11030459307543614 0.03672939744757358 3.382979462834001e-11 10.47070063868998 0.23620071831569123 YNDLYK(ub)FQQSDDLKK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNDLYKFQQSDDLKK 15 2 Q8N543;A0A0A0MTR2;H3BUA6;H3BR79 Q8N543 OGFOD1 Prolyl 3-hydroxylase OGFOD1 1 53014300.0 2685600.0 5466700.0 44862000.0 True False 3476562.1410903675 5162473.33938449 36697576.32299211 1.0 1.4849363048535538 10.555708436577092 21.729229946238522 -6.9179536699941755 0.8397556494406838 0.784718797490779 11.951789962904812 0.9935935019486634 0.351759637830718 0.09939105780375175 0.11196103321991371 0.2998372917306558 0.8813241302574785 1.20794269008703e-07 6.9179536699941755 11.167071165414033 up YNDNFFGLYCICK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNDNFFGLYCICK 13 0 Q8N806;H0YJM2;E9PCJ7;H0YJA0;G3V3Q6 Q8N806 UBR7 Putative E3 ubiquitin-protein ligase UBR7 0 2841030.0 1132500.0 921730.0 786800.0 False True 1484718.4671456013 784211.4768753999 705389.483518531 1.0 0.5281886729563356 0.47509982473287027 20.501757961926558 -13.999999999999998 0.3083978485471238 5.518197113403636 0.4631398965799412 0.9996684686913778 0.004295714940980406 17.15648106557331 0.17663880098296447 49.69828496322247 0.018518817027931296 1.0000000000000041e-14 13.999999999999998 -5.055057216823695 YNDNFFGLYCICK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNDNFFGLYCICK 13 0 Q8N806;H0YJM2;E9PCJ7;H0YJA0;G3V3Q6 Q8N806 UBR7 Putative E3 ubiquitin-protein ligase UBR7 0 3797700.0 1132500.0 1116200.0 1549000.0 False True 1551215.854661741 1066882.5932202032 1183158.1026563933 1.0 0.6877718468477414 0.7627295060843697 20.56496802344945 -10.750046455125059 8.800522333807631 1.0017346620513463 0.7252506764660563 0.9471276558933533 0.03060133624052631 0.001046799070302124 2.9731280957643795e-05 0.029779925891711224 0.009876538802604324 1.7780892032145095e-11 10.750046455125059 -0.27648398558528997 YNEDDAK(ub)AAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNEDDAKAAR 10 1 Q9Y4X5 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 13672700.0 4851800.0 5262600.0 3558300.0 True False 6360756.784898042 4477440.5934541365 3190121.2496237843 1.0 0.7039163333653398 0.5015317135215569 22.6007669928317 -8.04820936144204 0.12744740138237706 1.4203494069191767 8.819596091014761e-13 0.9999718189374436 0.0010866184882048656 0.1003555684537114 0.02215545535650365 0.10630618796253134 0.12197289650243678 8.949332388088285e-09 8.04820936144204 -1.4203494069182947 YNEDDAK(ub)AAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YNEDDAKAAR 10 1 Q9Y4X5 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 15182800.0 5730300.0 4827900.0 4624600.0 True False 5548394.763107633 6755705.647165899 3413278.5249738465 1.0 1.2175964284455594 0.6151830701862466 22.403639007042777 -6.8089923340504726 1.4187569369648516 1.118729479079853 0.6048842186664664 0.8571854843667952 0.09412652122887752 0.20817577132859705 0.8260616166344855 0.05216975940871625 0.12073585621406782 1.552414412160949e-07 6.8089923340504726 -0.5138452604133866 YNEDDAK(ub)AAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YNEDDAKAAR 10 1 Q9Y4X5 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 18912600.0 7377600.0 4825300.0 6709700.0 True False 11192358.57480637 3964187.5147590274 5383524.8540340215 1.0 0.3541869649961254 0.48100003391172247 23.416010752860448 -10.007945214994697 6.16189436190382 1.0000004490445353 0.41759349945609997 0.9656629916166329 0.051771218593369334 3.1936857477809785e-07 5.139802344726902e-08 0.05012730569576152 0.016709088952067134 9.818717955234459e-11 10.007945214994697 -0.5824069495884354 YNEDDAK(ub)AAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNEDDAKAAR 10 1 Q9Y4X5 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 13991390.0 4851800.0 5088500.0 4051090.0 True False 6645641.57496498 4863673.244580724 3094305.976817488 1.0 0.7318590973823854 0.46561433413353986 22.663977054354593 -6.971213126184139 0.2273594608610902 1.111921258924485 0.07796881860327964 0.9999903585740838 0.0006773840192528694 0.07591105311703901 0.007606827364412595 0.006976176527549719 0.02658086646833354 1.0685303786831273e-07 6.971213126184139 -1.0339524403212053 down YNEDDAK(ub)AAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YNEDDAKAAR 10 1 Q9Y4X5 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 13830090.0 5730300.0 6152700.0 1947090.0 True False 4764998.345332619 6119554.183884672 2354217.516673018 1.0 1.2842720480435967 0.49406470811873554 22.184044282477053 -6.809410322713129 1.4170698239017325 1.155032837036041 0.48043361180777167 0.8582696044615041 0.12303228892306367 0.2076049208035994 0.8217726834438146 0.06827145762420883 0.15796418573776094 1.5509210027650452e-07 6.809410322713129 -0.6745992252282693 down YNEDDAK(ub)AAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNEDDAKAAR 10 1 Q9Y4X5 Q9Y4X5 ARIH1 E3 ubiquitin-protein ligase ARIH1 1 19310500.0 7377600.0 7075500.0 4857400.0 True False 9550448.634237507 6681742.205135631 3973403.0411328473 1.0 0.6996260030321697 0.41604360101875754 23.187137074952897 -7.0746455901048595 0.22018401024540313 1.136631771036947 1.3609788252346877e-14 0.9999910421564319 0.0007135955949308003 0.07410968297206019 0.00777582605839749 0.008785615505262334 0.029137473568163368 8.420820499144485e-08 7.0746455901048595 -1.1366317710369334 down YNFFTGCPK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNFFTGCPKAK 11 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 16299900.0 2569300.0 7513600.0 6217000.0 True False 3368377.18113659 6392600.167783411 5573724.4776750235 1.0 1.8978278927855576 1.6547210059754307 21.68362226559296 -10.273898857004486 6.303129399078644 0.9999794266113338 1.7762744493804945 0.9314827356453417 0.09924797094022762 2.8694430232488375e-05 3.305538514972375e-06 0.09609897347504902 0.032032144883031397 5.3223219657886024e-11 10.273898857004486 0.7762950227691607 YNFFTGCPK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNFFTGCPKAK 11 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 10259000.0 2569300.0 2323400.0 5366300.0 True False 3519239.642721771 2220744.5055436445 4098890.4624176905 1.0 0.6310296345224523 1.1647091072342033 21.74683232711585 -6.72069633406928 1.7566347469648886 0.7756929176020271 1.1639199462661212 0.5158800057121793 0.15525085622334536 0.3539668544403596 2.134968702198429 0.07016187278222104 0.1760000974017266 1.9024080103313318e-07 6.72069633406928 0.3882270286640941 YNFFTGCPK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNFFTGCPKAK 11 1 Q99832;Q99832-3;Q99832-4;Q99832-2 Q99832 CCT7 T-complex protein 1 subunit eta 1 61036100.0 7811700.0 9119400.0 44105000.0 True False 10112399.641627783 8611897.373403136 36078342.55551618 1.0 0.8516175861911335 3.5677330637724567 23.269622049215926 -6.893985585448486 0.9985273796197837 0.8676956741135646 3.8204152471359465 0.9833284326254058 0.1609961358088725 0.11596817119818792 0.20344418700727268 0.12216527196280393 0.3092648793496735 1.2764811754521307e-07 6.893985585448486 2.9527195730223816 up YNFHGTAEQDLPFCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNFHGTAEQDLPFCK 15 0 P41240;H3BUM9;H3BN15 P41240 CSK Tyrosine-protein kinase CSK 0 22684900.0 6389200.0 6633700.0 9662000.0 False True 8376303.073100804 5643977.817960071 8662268.924448472 1.0 0.6738029616054402 1.034139864430885 22.99788221242256 -6.668289516076142 1.943200068208049 0.7914891235778346 1.0326811274201484 0.2716149822213352 0.13861532281138844 0.4650425255757331 3.383696767564042 0.057458032074030455 0.15386990846652743 2.1463991314457608e-07 6.668289516076142 0.24119200384231376 YNFHGTAEQDLPFCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNFHGTAEQDLPFCK 15 0 P41240;H3BUM9;H3BN15 P41240 CSK Tyrosine-protein kinase CSK 0 15575300.0 6389200.0 4809900.0 4376200.0 False True 8751459.901637774 4597382.713787713 3342631.6906681163 1.0 0.5253275185466307 0.38195132334921245 23.06109227394545 -13.999999999999998 0.16773471425476233 3.3799245198305763 0.2523781629860431 0.9995181846409296 0.00579760311803303 12.070265732783776 0.12964478020451356 9.345180602123847 0.11934823809699562 1.0000000000000041e-14 13.999999999999998 -3.127546356844533 YNFLGISIVGQSNER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNFLGISIVGQSNER 15 0 I3L2N2;O14641;I3L0M7;I3L2W9;A0A3B3ITC6;Q92997-2;Q92997 I3L2N2;Q92997-2 DVL2;DVL3 Segment polarity protein dishevelled homolog DVL-2;Segment polarity protein dishevelled homolog DVL-3 0 14170400.0 4090400.0 6828200.0 3251800.0 False True 5295103.433838261 6448204.667529809 2660005.7662856225 1.0 1.2177674615990834 0.5023519935959899 22.336227435227915 -6.825037152511263 1.349990796950298 1.1168147735424774 0.48498716764814204 0.8955705129062378 0.09676069143918523 0.18701489873943672 0.6682992005481082 0.05630389465315855 0.1296272243053704 1.496107663368939e-07 6.825037152511263 -0.6318276058943353 YNGLIHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNGLIHR 7 0 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 8027350.0 815250.0 4135200.0 3076900.0 False True 1068800.644892231 3518244.278883353 2758531.9037089096 1.0 3.291768484325815 2.5809601789555963 20.027561352741426 -10.060153717522141 5.4328359828020405 0.9999848310220513 2.93636433164215 0.9082132608605692 0.29018627551998233 5.331642798302354e-05 9.224029502147084e-06 0.2809738449516572 0.09365721769816929 8.706553689686629e-11 10.060153717522141 1.9363795006200988 YNGLIHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNGLIHR 7 0 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 8162850.0 815250.0 3937200.0 3410400.0 False True 1116669.956302856 3763241.4854206936 2604933.7593927463 1.0 3.370057073873716 2.332769628742705 20.090771414264317 -10.561649103556688 6.702137286095452 0.99786393002696 2.851413351308209 0.8094379962585552 0.42347082619436344 0.013517030564964835 0.0008840760874196538 0.4100494752429392 0.13667462145462206 2.7437901737592058e-11 10.561649103556688 1.853549421281249 YNGLIHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNGLIHR 7 0 P46779;H0YKD8;P46779-2;P46779-3;H0YMF4;P46779-4;P46779-5;H0YLP6 P46779 RPL28 60S ribosomal protein L28 0 3785730.0 1136500.0 638230.0 2011000.0 False True 1471221.6537642241 602711.93945074 1645018.6346024955 1.0 0.4096676649019263 1.1181310650190606 20.48858318824618 -6.685572335816042 1.8819325986999322 0.6283660666098926 1.1155697431137683 0.34975679165853735 0.24989979407424462 0.4263284003985706 2.923801620487125 0.10636292890042738 0.27855438417887346 2.0626600833304092e-07 6.685572335816042 0.48720367650387575 YNHAACFGLQPGCLLPDGSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNHAACFGLQPGCLLPDGSR 20 0 E9PCB6;Q9BYT8;H0YAK4;H0YAF7 E9PCB6 NLN Neurolysin, mitochondrial 0 20742200.0 11605000.0 9137200.0 0.0 False True 15214267.382979872 7773965.376526645 0.0 1.0 0.5109654760782858 0.0 23.858921529224805 -7.895170235771817 0.5997577682443213 1.0088952560486888 3.210442634141681e-18 0.9887403375542245 0.04332333363234444 0.11335711289148663 0.16007728539993088 0.04437606277797139 0.07730234695714261 1.2730039881098157e-08 7.895170235771817 -1.0088952560486888 down YNHAACFGLQPGCLLPDGSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YNHAACFGLQPGCLLPDGSR 20 0 E9PCB6;Q9BYT8;H0YAK4;H0YAF7 E9PCB6 NLN Neurolysin, mitochondrial 0 24037000.0 5796400.0 12279000.0 5961600.0 False True 8793562.573602209 10087716.513735104 4783287.1469379 1.0 1.1471706068275302 0.5439532734203842 23.068016338332477 -6.84221533506791 1.2721076056932878 1.0782798782879432 0.5232312056577387 0.9281964659841564 0.06881217609312298 0.16622131436215964 0.5215595021862308 0.042400547123675254 0.09774615525310225 1.4380853594478518e-07 6.84221533506791 -0.5550486726302045 YNHAACFGLQPGCLLPDGSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNHAACFGLQPGCLLPDGSR 20 0 E9PCB6;Q9BYT8;H0YAK4;H0YAF7 E9PCB6 NLN Neurolysin, mitochondrial 0 20732500.0 5796400.0 5839400.0 9096700.0 False True 7503554.064125771 5514432.256754863 7441193.940024115 1.0 0.7349093788927531 0.9916892550425142 22.839142660424926 -10.706388803966469 9.018758512093932 1.000307441302209 0.8632993170044577 0.27424933204771684 0.10482994546366244 0.0006494630383205328 2.114351195452054e-05 0.1017253142696188 0.03383371941371636 1.966125319582421e-11 10.706388803966469 -0.13700812429775133 YNHIDESEMK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 YNHIDESEMKK 11 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;Q5TBM3 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 12205400.0 3204500.0 4410600.0 4590300.0 True False 3102774.9015546185 6171775.580975152 3387962.723951795 1.0 1.9891148332683872 1.091913796986783 21.565127606122996 -6.622952480779124 2.1065500962303574 1.6549765723666738 1.0954422934666033 0.09254210304344412 0.4250427697745269 0.5775818293384326 4.874690987669211 0.1655838709561332 0.47098401568016096 2.3825801499874728e-07 6.622952480779124 -0.5595342789000706 YNHIDESEMK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 YNHIDESEMKK 11 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;Q5TBM3 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 33621900.0 7189900.0 14994000.0 11438000.0 True False 10907603.952098299 12318203.551343296 9177274.286546513 1.0 1.1293225905010642 0.8413648246534546 23.378830887223412 -6.784605099938177 1.5177864727205574 1.072787554402331 0.8387395742914123 0.7833953087641354 0.05480697644692681 0.24348185001801484 1.1080847805507341 0.02843215283461365 0.06683845761151148 1.6420822251414693e-07 6.784605099938177 -0.23404798011091876 YNHIDESEMK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNHIDESEMKK 11 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;Q5TBM3 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 27687300.0 7189900.0 13043000.0 7454400.0 True False 9307467.284117373 12317145.584281538 6097775.6886031 1.0 1.323361684579864 0.6551487641550547 23.14995720931586 -6.775110310381268 1.554820001681438 1.1842576196089678 0.6506354141733152 0.7497463644765687 0.1364910860757157 0.2582448644221431 1.2326888250973793 0.06916633639519877 0.16389002264302685 1.678377657664297e-07 6.775110310381268 -0.5336222054356526 YNHIDESEMKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNHIDESEMKK 11 1 Q92598-2;Q92598;Q92598-3;Q92598-4;A0A0A0MSM0;Q5TBM3 Q92598-2 HSPH1 Heat shock protein 105 kDa 1 3981400.0 1040200.0 1154600.0 1786600.0 True False 1424790.0503480278 1103585.9542483832 1364641.8761819946 1.0 0.7745604020598085 0.9577845352363732 20.442317916224688 -9.988347496827018 5.7265324031024285 1.0000002154193048 0.8661724687421147 0.41565535759474237 0.07480093914128016 2.057252026399492e-07 3.637305556092014e-08 0.07242581444970193 0.024141899297871673 1.0271940691169792e-10 9.988347496827018 -0.1338277466771901 YNIEK(ub)DIAAHIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNIEKDIAAHIK 12 1 P63167;F8VXL2;F8VRV5 P63167 DYNLL1 Dynein light chain 1, cytoplasmic 1 32794600.0 11287000.0 11939000.0 9568600.0 True False 14797366.303463494 10157747.737857508 8578533.060492404 1.0 0.6864564632342696 0.5797337772522736 23.818837086075998 -13.999999999999998 0.15044443481656197 2.5171603077249607 0.4629154915060101 0.9995647623409254 0.0037210847180160008 11.959441607802798 0.12217856611687125 5.303477080004121 0.10533898264307788 1.0000000000000041e-14 13.999999999999998 -2.054244816218951 YNIEK(ub)DIAAHIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YNIEKDIAAHIK 12 1 P63167;F8VXL2;F8VRV5 P63167 DYNLL1 Dynein light chain 1, cytoplasmic 1 43599000.0 12694000.0 14198000.0 16707000.0 True False 12291035.918344287 19867335.441591896 12330935.50074343 1.0 1.616408541442795 1.0032462343015036 23.55110317888677 -6.644989865150808 2.026759758040521 1.4015707169853062 1.005830992317546 0.17387027980740544 0.26341831620519646 0.5209120817523842 4.0956122365685435 0.10562682038050893 0.2916628807915983 2.2646971567479445e-07 6.644989865150808 -0.3957397246677603 YNIEK(ub)DIAAHIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YNIEKDIAAHIK 12 1 P63167;F8VXL2;F8VRV5 P63167 DYNLL1 Dynein light chain 1, cytoplasmic 1 133968000.0 36495000.0 25568000.0 71905000.0 True False 55365583.14188342 21005190.636304203 57692945.232918955 1.0 0.37939075946287687 1.0420362607772284 25.722486097882832 -11.858050683572255 14.19812844536917 0.9218702027536707 0.7396421591087419 0.0 0.31038120056053176 0.0 0.0 0.0 0.09009008223630773 1.3865939994196287e-12 11.858050683572255 -0.18222804364492884 YNIEK(ub)DIAAHIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNIEKDIAAHIK 12 1 P63167;F8VXL2;F8VRV5 P63167 DYNLL1 Dynein light chain 1, cytoplasmic 1 37758000.0 11287000.0 10544000.0 15927000.0 True False 15460108.919706028 10078131.21565474 12165370.626861446 1.0 0.651879703305892 0.7868877696815585 23.88204714759889 -10.042428385068312 4.833542064111365 1.0000066016145122 0.7193837371137966 0.8520775327664991 0.05511681231207505 76294743.51045588 6.08798423602937 5605.611506889327 0.018867950873367588 9.069255037927567e-11 10.042428385068312 -0.2806228645007156 YNIEK(ub)DIAAHIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YNIEKDIAAHIK 12 1 P63167;F8VXL2;F8VRV5 P63167 DYNLL1 Dynein light chain 1, cytoplasmic 1 33694300.0 12694000.0 14276000.0 6724300.0 True False 10555623.439549804 14199092.354435854 8130320.040349632 1.0 1.3451685194864667 0.77023589245207 23.331508454321046 -6.744138034048766 1.6716951128229758 1.2043841870699155 0.7695950314536537 0.6233202295911138 0.1450188466980699 0.3103747064432425 1.7045930687851116 0.06858737578077774 0.16753916883837244 1.8024447695180832e-07 6.744138034048766 -0.43478915561626175 YNIEK(ub)DIAAHIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNIEKDIAAHIK 12 1 P63167;F8VXL2;F8VRV5 P63167 DYNLL1 Dynein light chain 1, cytoplasmic 1 146126000.0 36495000.0 32601000.0 77030000.0 True False 47243496.92399944 30786725.69141779 63011330.394545 1.0 0.6516606029596911 1.3337566966287708 25.493612419975282 -6.767883750234517 1.5823805571301857 0.7996530626079965 1.3373016944509555 0.7223853109331464 0.1467317979824431 0.26990754212881135 1.3334170225251485 0.07310161285939602 0.17436450269821738 1.7065391256932373e-07 6.767883750234517 0.537648631842959 YNIK(ub)LWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YNIKLWK 7 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;P62136;P62136-2;P62136-3 P36873;P62136 PPP1CC;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 12093600.0 2328200.0 4036400.0 5729000.0 True False 2254292.5653922455 5648155.56954793 4228403.033684032 1.0 2.5055113325830245 1.8757117415007278 21.1042433320615 -10.451176049332233 5.716787044015148 0.9991325180721924 2.1906115370418777 0.8265431781029609 0.2571146063941923 0.0028444620735114338 0.00027307457439373705 0.24909875956418417 0.08298338238594781 3.5385387076933555e-11 10.451176049332233 1.1914790189696853 YNIK(ub)LWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YNIKLWK 7 1 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;P62136;P62136-2;P62136-3 P36873;P62136 PPP1CC;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 1 9512100.0 2328200.0 3905500.0 3278400.0 True False 1936001.4567480579 3884460.2963189455 3963898.2823910653 1.0 2.006434593723785 2.047466580448399 20.884648607495777 -10.967030777372832 0.5605079366915654 1.2344636666588247e-20 2.0436303551893276 0.9998709078140238 0.005503676094295305 2.7840770999117863 0.27427628453102315 3.620730796322833 0.007538282910039882 1.0788702626608185e-11 10.967030777372832 2.0436303551893276 YNILGTNTIMDK ddPTM_RPMI8226_Bortezomib_1h_R1 2 YNILGTNTIMDK 12 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 92759700.0 13853000.0 40596800.0 38309900.0 False True 18161417.152642816 34539915.685087 34345959.04250961 1.0 1.901829322832377 1.891149724376638 24.114373446098075 -10.12380621551317 5.371580348563114 0.9999823802434136 1.896489523604915 0.9998935770693791 0.004359927813825799 9.200111436950264e-07 1.5007269735674562e-07 0.004221564720343149 0.0014071606509277678 7.519583469499085e-11 10.12380621551317 0.8965071433615015 YNILGTNTIMDK ddPTM_RPMI8226_Bortezomib_2h_R1 2 YNILGTNTIMDK 12 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 82658400.0 26099100.0 10343300.0 46216000.0 False True 25270598.356425032 14473433.629596945 34110643.14971915 1.0 0.5727380660108938 1.349815412702586 24.590956488985995 -6.757454092164386 1.6223241551827046 0.7510353304120119 1.3522763567025062 0.6803871477388848 0.17964640020762396 0.28721351301322146 1.4893036162988447 0.08740001736681022 0.21054480430085176 1.748018029866337e-07 6.757454092164386 0.6012410262904944 YNILGTNTIMDK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 YNILGTNTIMDK 12 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 75718300.0 13853000.0 25304100.0 36561200.0 False True 18974828.46324863 24186081.192531187 27926197.561550003 1.0 1.2746403077833333 1.4717496717105412 24.177583507620966 -6.974717897474061 0.09116705034454486 0.4341850950559147 2.31717931130187 0.9999998261875248 8.044650479453742e-05 0.07479923564115802 0.0026612918849300247 0.020077039475092918 0.034598918146447104 1.0599420029147964e-07 6.974717897474061 1.8829942162459552 YNILGTNTIMDK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 YNILGTNTIMDK 12 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 43066700.0 26099100.0 6844400.0 10123200.0 False True 21702558.036170967 6807527.858692966 12239914.31561166 1.0 0.3136739847600949 0.5639848673696337 24.37136176442027 -10.266853123891057 5.589214813404656 1.0000448104710786 0.43882942606505726 0.8701543918872738 0.10218898990989392 5.706518372858786e-05 7.485455317897119e-06 0.09895193206830002 0.032981354673890934 5.409372341407347e-11 10.266853123891057 -0.5612153844060214 YNILGTNTIMDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNILGTNTIMDK 12 0 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 0 14577500.0 0.0 11691000.0 2886500.0 False True 0.0 11040385.572785063 2361186.617991097 0.0 YNILGTNTIMDK(ub)MMVAGFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YNILGTNTIMDKMMVAGFK 19 1 Q00839;Q00839-2;A0A1X7SBS1;A0A1W2PPS1;Q5RI18;A0A1W2PP35;A0A1W2PPH7;A0A1W2PPL4;A0A1W2PP34;A0A1W2PQL0;A0A1W2PQ74;A0A1W2PRZ7;A0A1W2PQD4 Q00839 HNRNPU Heterogeneous nuclear ribonucleoprotein U 1 14536100.0 4753700.0 5273900.0 4508500.0 True False 4602796.395543829 7379795.77302518 3327588.5978991874 1.0 1.603328746014029 0.7229493359994749 22.134079195758254 -6.722286654556739 1.7514880145994793 1.3661649835429246 0.7241792900360429 0.5231298736248888 0.2538138575840312 0.35088171301354726 2.104926020257424 0.11501914962327689 0.2879237454133073 1.8954544201587846e-07 6.722286654556739 -0.6419856935068817 YNIMLVR ddPTM_RPMI8226_Bortezomib_1h_R1 2 YNIMLVR 7 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 128578600.0 29002900.0 29982700.0 69593000.0 False True 38023082.76448313 25509398.031649217 62392183.943194084 1.0 0.6708924205240195 1.6409028255192872 25.180372169073713 -6.815143254332385 1.3926175497940723 0.8216969306844181 1.659977971560208 0.872888098261883 0.143597393920059 0.19986026524064024 0.7628684548004101 0.08105281408386701 0.18711067693850764 1.5305825076684026e-07 6.815143254332385 0.83828104087579 YNIMLVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YNIMLVR 7 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 75614000.0 18969000.0 9779000.0 46866000.0 False True 18366839.478105653 13683805.696811313 34590388.65013721 1.0 0.7450277829848303 1.8833065259469912 24.130600056499144 -6.847891020907957 1.2451799627208078 0.8641425594289748 1.9270039789575524 0.9371876494112767 0.1222366563697267 0.15979066055574834 0.4778129174382075 0.07685541658132368 0.17762975278350532 1.4194136556292657e-07 6.847891020907957 1.0628614195285775 YNIMLVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YNIMLVR 7 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 76683000.0 21717000.0 39341000.0 15625000.0 False True 32946276.725367326 32320291.177364025 12536711.901319228 1.0 0.9809998090764133 0.3805198385791028 24.973612098993947 -6.91364200079324 0.8705671630734061 1.0165198314070014 0.29655504851855674 0.9922248185645044 0.025364283507534138 0.1020588317847356 0.1260687958166333 0.021147474664672858 0.05996016124656759 1.2199948551355636e-07 6.91364200079324 -0.7199647828884447 down YNIMLVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNIMLVR 7 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 74737000.0 22852000.0 25100000.0 26785000.0 False True 31301001.952079546 23990999.005399615 20458934.65439089 1.0 0.7664610558514637 0.6536191616393819 24.8997055030998 -13.99999999973303 0.09596252217401761 2.168337319908278 0.39749389895356474 0.999813755274427 0.0019684924085607773 12.112423198622345 0.09141240135109405 2.83326008891916 0.22902081876234187 1.0000000006147222e-14 13.99999999973303 -1.770843420954713 YNIMLVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YNIMLVR 7 0 P50990;P50990-2;P50990-3;H7C4C8 P50990 CCT8 T-complex protein 1 subunit theta 0 40154000.0 18969000.0 21185000.0 0.0 False True 15773563.96918391 21070872.200106725 0.0 1.0 1.3358345800145055 0.0 23.91100533193342 -6.873258431356567 1.3544098571524743 1.1759147120852316 4.2308107468071976e-20 0.9235817251999197 0.15684457891069137 0.15420709254619544 0.5687506121717487 0.09374676309354117 0.19254154545563815 1.338879736303316e-07 6.873258431356567 -1.1759147120852316 down YNKPAFLK(ub)NAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YNKPAFLKNAR 11 2 Q9NPD8 Q9NPD8 UBE2T Ubiquitin-conjugating enzyme E2 T 1 3990200.0 1154900.0 1202300.0 1633000.0 True False 1118238.3316602993 1682384.6599116705 1205268.3110501007 1.0 1.5044956091012882 1.077827755430798 20.09279627383825 -10.22942088021912 6.382850188042833 0.9999964872965842 1.2911616822660432 0.38306187983462825 0.17418642185686403 8.707338690167884e-06 1.050907381362131e-06 0.16865731046258237 0.05621842591559106 5.896293859793712e-11 10.22942088021912 0.29116519496945903 YNKPAFLK(ub)NAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNKPAFLKNAR 11 2 Q9NPD8 Q9NPD8 UBE2T Ubiquitin-conjugating enzyme E2 T 1 16172200.0 1868200.0 3169000.0 11135000.0 True False 2418421.727727515 2992642.364225119 9108544.254748272 1.0 1.2374361055038874 3.7663175741094466 21.205634415006767 -6.925187971983162 0.78528858763244 0.9539250812008625 4.227112536373222 0.9955049781761615 0.08393011195753304 0.0952144061430562 0.09049371391281955 0.07437857924577837 0.23516388693556756 1.1879879294440738e-07 6.925187971983162 3.27318745517236 up YNLAVVWLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNLAVVWLR 9 0 Q9Y5Q9;A0A494C1S7;H7C143 Q9Y5Q9 GTF3C3 General transcription factor 3C polypeptide 3 0 4694710.0 859410.0 2704800.0 1130500.0 False True 1126694.8325382785 2301254.3832278205 1013526.7045217328 1.0 2.0424824156186383 0.8995574269550926 20.103665381017624 -6.66671214991806 1.9494442015698898 1.6672845196575001 0.9042691941170791 0.2644904280940441 0.4431615460801673 0.46864302041179395 3.430484789644661 0.18323760229063907 0.49159914127604215 2.1542090699339035e-07 6.66671214991806 -0.7630153255404211 YNLAVVWLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNLAVVWLR 9 0 Q9Y5Q9;A0A494C1S7;H7C143 Q9Y5Q9 GTF3C3 General transcription factor 3C polypeptide 3 0 6169010.0 859410.0 1547200.0 3762400.0 False True 1177157.101681983 1478839.5880937965 2873798.609060304 1.0 1.256280564404491 2.4413042277484216 20.166875442540515 -6.941563367263041 0.6448540971887473 0.9869743314303943 2.7761227855359274 0.9983615995536393 0.025412001148080742 0.08706057151887267 0.05141543900570926 0.02504019287592852 0.10131076263184513 1.1440279442198607e-07 6.941563367263041 1.7891484541055331 up YNLDFWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNLDFWR 7 0 Q13630;E9PKL9;E9PP14;A0A0J9YX13;E9PLH9;H0YE90 Q13630 TSTA3 GDP-L-fucose synthase 0 4278300.0 1807600.0 2470700.0 0.0 False True 2369781.104823299 2102081.1907131677 0.0 1.0 0.8870360162948078 0.0 21.1763223737766 -7.131672924678461 0.9561663518135863 0.9961594063220006 1.0276982018491129e-19 0.9896913093007464 0.0454012421711318 0.08640913202663988 0.14969683137840104 0.03781442186444795 0.06652244881054468 7.384601689653518e-08 7.131672924678461 -0.9961594063220006 down YNLDFWR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YNLDFWR 7 0 Q13630;E9PKL9;E9PP14;A0A0J9YX13;E9PLH9;H0YE90 Q13630 TSTA3 GDP-L-fucose synthase 0 7127880.0 2963700.0 939380.0 3224800.0 False True 2869618.965747362 1314479.3328019856 2380128.138073708 1.0 0.4580675512993215 0.8294230580727392 21.45242775475429 -10.1516433166642 5.651045317820315 1.000005723458441 0.6437453046860101 0.550985721595942 0.15160525079469012 1.0932357707772767e-05 1.6412359578096218e-06 0.1467935122352936 0.048930384293771514 7.052720666986831e-11 10.1516433166642 -0.35626041877243086 YNLDFWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNLDFWR 7 0 Q13630;E9PKL9;E9PP14;A0A0J9YX13;E9PLH9;H0YE90 Q13630 TSTA3 GDP-L-fucose synthase 0 9167900.0 1807600.0 3410500.0 3949800.0 False True 2475918.568553254 3259812.8329846826 3016938.588684456 1.0 1.3166074500137859 1.2185128489291692 21.23953243529949 -10.080837076262522 4.365416628917704 0.9999761973108683 1.2675601494385182 0.9084210202278955 0.04004695330661796 27823250.495266084 0.39999883505112394 7270.058605518375 0.013709137286838003 8.301621409204881e-11 10.080837076262522 0.26758395212764996 YNLDFWR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YNLDFWR 7 0 Q13630;E9PKL9;E9PP14;A0A0J9YX13;E9PLH9;H0YE90 Q13630 TSTA3 GDP-L-fucose synthase 0 7118600.0 2963700.0 2774000.0 1380900.0 False True 2464447.864171561 2759055.9114041114 1669639.8054397947 1.0 1.1195432256918874 0.6774904146738987 21.232833030188566 -6.834710592070533 1.306910481686346 1.0636961175187536 0.6644245222978139 0.9149362574011731 0.05445248838438723 0.17507308158379034 0.5831595296460154 0.03269802486459673 0.07524913819472669 1.4631518741442716e-07 6.834710592070533 -0.3992715952209397 YNLGISCINLGAHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNLGISCINLGAHR 14 0 B4E0T2;P50542-3;P50542;P50542-4;P50542-2 B4E0T2 PEX5 Peroxisomal targeting signal 1 receptor 0 15187200.0 4231900.0 4953500.0 6001800.0 False True 5548061.881777902 4214457.108591768 5380791.309330862 1.0 0.759626910873825 0.9698506296412401 22.403552448556745 -10.215946825877904 6.811589420652087 1.000000617340824 0.8647387703556089 0.3556610752615146 0.08582347380175322 8.045896334996624e-07 9.262144093876067e-08 0.08309860070735552 0.027699407062321553 6.082094646345237e-11 10.215946825877904 -0.13526184698521515 YNLGISCINLGAHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNLGISCINLGAHR 14 0 B4E0T2;P50542-3;P50542;P50542-4;P50542-2 B4E0T2 PEX5 Peroxisomal targeting signal 1 receptor 0 18501800.0 4231900.0 4693200.0 9576700.0 False True 5796547.792797374 4485838.905663014 7314880.698327622 1.0 0.7738811213179319 1.2619374427339125 22.466762510079636 -6.780727359339993 1.5330820370634315 0.8720876824364602 1.2658893895400791 0.769948927094331 0.09565241934537608 0.24944122489360585 1.158052899474494 0.0491396675595505 0.11587648742539136 1.6568097462970433e-07 6.780727359339993 0.39380170710361895 YNLGISCINLGAHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YNLGISCINLGAHR 14 0 B4E0T2;P50542-3;P50542;P50542-4;P50542-2 B4E0T2 PEX5 Peroxisomal targeting signal 1 receptor 0 6485130.0 2428300.0 684730.0 3372100.0 False True 2019239.0419299516 681041.2235817366 4077190.519171218 1.0 0.33727617653965813 2.0191717941796106 20.94538027949489 -6.799815682954229 1.4566404402688893 0.634250500036526 2.042286116624157 0.8316085611767995 0.2838640520039989 0.22103494697678028 0.9259220285588324 0.15330752993277577 0.35658082012980447 1.5855659728931416e-07 6.799815682954229 1.4080356165876307 YNLGLDLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNLGLDLR 8 0 P00367;P00367-3;P00367-2;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 46958000.0 10299000.0 14477000.0 22182000.0 False True 13502088.73565788 12317088.030904008 19886819.42476875 1.0 0.9122357490049384 1.4728698510364053 23.686679269671373 -6.866883988976614 1.1503599740630917 0.9511802358911856 1.503828672940535 0.961478046338801 0.04832564503054213 0.13988258983793123 0.34791032201968375 0.03265864722633376 0.07693425951651851 1.3586763348764793e-07 6.866883988976614 0.5526484370493494 YNLGLDLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YNLGLDLR 8 0 P00367;P00367-3;P00367-2;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 35940400.0 14117000.0 6304400.0 15519000.0 False True 13668863.562255124 8821779.797011677 11454108.339979485 1.0 0.645392336885411 0.8379707857797768 23.704389965586174 -10.098017272942633 5.20126689276021 1.0000052565707085 0.7416815613322242 0.7057977020911297 0.0786198225425977 4.792483134320386e-06 8.309431760323275e-07 0.07612486505015732 0.025374438615586224 7.979629497190867e-11 10.098017272942633 -0.2583236952384843 YNLGLDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YNLGLDLR 8 0 P00367;P00367-3;P00367-2;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 28178300.0 5945300.0 10060000.0 12173000.0 False True 9019454.759650337 8264714.400861248 9767001.21438457 1.0 0.9163208443413327 1.0828815571068084 23.104608792236743 -6.770169795953089 1.5743481165715576 0.952012817586133 1.0838121494634518 0.7310032863921351 0.035267289925315574 0.26616134613856485 1.3020519925065739 0.01765890518218725 0.04201964924106205 1.6975798205460696e-07 6.770169795953089 0.13179933187731885 YNLGLDLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNLGLDLR 8 0 P00367;P00367-3;P00367-2;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 42794200.0 10299000.0 7551200.0 24944000.0 False True 14106818.620009953 7217563.015520872 19052740.937805735 1.0 0.5116364794882278 1.350605083330425 23.749889331194264 -6.7489058955707355 1.6538798863404847 0.7124597074148223 1.3521354777377166 0.6442508373494029 0.20520354172221686 0.3019597810183321 1.6247266937459037 0.09802716999944242 0.23825880977694652 1.7827650212852343e-07 6.7489058955707355 0.6396757703228942 YNLGLDLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YNLGLDLR 8 0 P00367;P00367-3;P00367-2;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 31459400.0 14117000.0 9204800.0 8137600.0 False True 11738910.989138551 9155211.915390255 9839134.535988752 1.0 0.7799030015527958 0.8381641657469274 23.48479524102045 -10.799891885059058 6.456902627302909 1.009747166420456 0.8090335836500836 0.9347471114400165 0.023785020682688666 0.0034359743400334975 0.00010648534496997366 0.023709977014954337 0.007676582416104346 1.585287790990814e-11 10.799891885059058 -0.20071358277037243 YNLGLDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNLGLDLR 8 0 P00367;P00367-3;P00367-2;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 28833400.0 5945300.0 13588000.0 9300100.0 False True 7696308.049383574 12831815.855188044 7607577.227084355 1.0 1.6672690038980171 0.9884709887221412 22.875735114329192 -6.650075399690562 2.0080263386676855 1.4329609498049756 0.9913109674266654 0.19444028028845883 0.2847915409557812 0.5083534823687579 3.9289551209738875 0.11501229386901991 0.3154906903063167 2.2383324985186926e-07 6.650075399690562 -0.4416499823783102 YNLGTIHWR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNLGTIHWR 9 0 Q96HA7;Q96HA7-2;A0A087X1F6 Q96HA7 TONSL Tonsoku-like protein 0 4875500.0 1110800.0 1057600.0 2707100.0 False True 1456269.5570025009 899810.2024925111 2426995.2603368293 1.0 0.6178871199811574 1.6665838056330813 20.473845993924442 -6.8081051905478756 1.4224643867469262 0.791281168512195 1.6841494126039878 0.8548292967133782 0.16511084031858575 0.2093944764320352 0.8354025201204529 0.09127851929070765 0.21133490209115904 1.5555888065150387e-07 6.8081051905478756 0.8928682440917928 YNLGTIHWR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNLGTIHWR 9 0 Q96HA7;Q96HA7-2;A0A087X1F6 Q96HA7 TONSL Tonsoku-like protein 0 3453590.0 1110800.0 883690.0 1459100.0 False True 1521492.778241289 844645.6538279523 1114490.6311077748 1.0 0.5551427295003581 0.7324981406721018 20.537056055447334 -10.137169019546919 5.245957876023135 1.000010599710928 0.6438204350859744 0.8432010063017299 0.0724050434162734 8.976393389193987e-06 1.4764821262939388e-06 0.07010796687991552 0.023368627277592226 7.291736738382449e-11 10.137169019546919 -0.3561901646249537 YNLIAVSNHYGGMGGGHYTAFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNLIAVSNHYGGMGGGHYTAFAK 23 0 Q9Y4E8-2;Q9Y4E8-3;Q9Y4E8;H0YI26 Q9Y4E8-2 USP15 Ubiquitin carboxyl-terminal hydrolase 15 0 16462700.0 6415700.0 7455900.0 2591100.0 False True 8411044.82972718 6343508.782870568 2322997.8275862588 1.0 0.7541879649066531 0.27618421665951426 23.003853594184907 -6.97535641000225 0.4307491979995165 1.0189695570002044 1.4396251380872894e-20 0.9997929112595658 0.004324679290953662 0.07735030753395979 0.020382911708140897 0.0061723004248304065 0.03859653685377932 1.0583847899996061e-07 6.97535641000225 -1.0189695570002044 down YNLIAVSNHYGGMGGGHYTAFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNLIAVSNHYGGMGGGHYTAFAK 23 0 Q9Y4E8-2;Q9Y4E8-3;Q9Y4E8;H0YI26 Q9Y4E8-2 USP15 Ubiquitin carboxyl-terminal hydrolase 15 0 21932700.0 6415700.0 3639200.0 11877800.0 False True 8787757.667773359 3478408.110774917 9072508.270969732 1.0 0.3958243094857981 1.032403101446529 23.0670636557078 -10.107672300374839 13.582581564419318 0.9999942305047322 0.7141137054661636 0.2119274745724311 0.259882203584867 0.0 0.0 0.251629861605323 0.08387662053510765 7.804187582801511e-11 10.107672300374839 -0.28588052503856864 YNLYTAEGK(ub)YIFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNLYTAEGKYIFK 13 1 H0YE76;H0YCB3;A0A5F9ZH79;Q8N9N2-2;Q8N9N2;H0YER2;A0A5F9ZHP1 H0YE76 ASCC1 Activating signal cointegrator 1 complex subunit 1 1 5490100.0 1539400.0 1128400.0 2822300.0 True False 2018168.3075708041 960047.11846875 2530275.46941326 1.0 0.47570220722786194 1.2537484906097156 20.94461506407195 -6.725176996759933 1.7408592337920612 0.6827997529192645 1.2528913594743887 0.5367797011895553 0.22049765547294697 0.3453390353203357 2.0480204967178577 0.10046914476207996 0.2506760637678175 1.8828815645263258e-07 6.725176996759933 0.5700916065551241 YNLYTAEGK(ub)YIFK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YNLYTAEGKYIFK 13 1 H0YE76;H0YCB3;A0A5F9ZH79;Q8N9N2-2;Q8N9N2;H0YER2;A0A5F9ZHP1 H0YE76 ASCC1 Activating signal cointegrator 1 complex subunit 1 1 34974500.0 3678100.0 7598400.0 23698000.0 True False 5579946.6051284075 6242406.153429836 19014079.912797607 1.0 1.1187214852006964 3.4075738099934827 22.41181988620211 -6.917649232423662 0.8419748787789572 0.9450934531372824 3.757429882322496 0.9935026693074792 0.08931298880697074 0.09957485137386271 0.11292636527898701 0.0760093090815668 0.22281060035939457 1.2087897468102917e-07 6.917649232423662 2.8123364291852138 up YNLYTAEGK(ub)YIFK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNLYTAEGKYIFK 13 1 H0YE76;H0YCB3;A0A5F9ZH79;Q8N9N2-2;Q8N9N2;H0YER2;A0A5F9ZHP1 H0YE76 ASCC1 Activating signal cointegrator 1 complex subunit 1 1 33124900.0 3678100.0 7431300.0 22015500.0 True False 4761372.956190224 7017741.622362301 18008904.898106024 1.0 1.4738903435906212 3.7822924319954367 22.18294620829456 -6.940389153004715 0.6559323934024438 0.9742522602291854 4.4119883402910425 0.9982144385078442 0.05135718705588982 0.08758953073727335 0.05380438458188235 0.050141032372350076 0.19834132279145675 1.1471252701652352e-07 6.940389153004715 3.437736080061857 up YNNPAMLHNIDQEMLK(ub)CIELDER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YNNPAMLHNIDQEMLKCIELDER 23 1 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 15603900.0 10237000.0 3969300.0 1397600.0 True False 8512519.07599428 3947916.5930556403 1689831.6982277199 1.0 0.4637777087852829 0.1985113552336262 23.02115469543702 -9.254000687492484 0.23060304544704535 1.394948525736667 1.1848341834378795e-15 0.9992891362347934 0.008888605688176262 0.6763462362965574 0.08468752662202596 0.32368884262310216 0.12295289761779819 5.571848669020463e-10 9.254000687492484 -1.3949485257366658 YNNPAMLHNIDQEMLK(ub)CIELDER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNNPAMLHNIDQEMLKCIELDER 23 1 Q9UNS2;Q9UNS2-2;H7C3P9 Q9UNS2 COPS3 COP9 signalosome complex subunit 3 1 37748300.0 14688000.0 14231000.0 8829300.0 True False 19013905.543764982 13439032.339945598 7222457.996268416 1.0 0.7068002051978485 0.3798513661301318 24.18055156284214 -6.993564141027458 0.267809781487115 1.084575959566333 1.9171412086829366e-11 0.999980251272046 0.0011256367971994796 0.07388117679504924 0.009374562665518444 0.006488943606906538 0.02966503211915367 1.0149294603948558e-07 6.993564141027458 -1.0845759595471616 down YNQLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNQLLR 6 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 78090700.0 5664700.0 47764000.0 24662000.0 False True 7426476.557032836 40637797.382613726 22110212.814608544 1.0 5.472015843654678 2.9772143821918196 22.824246465234335 -9.915357488773124 8.449130767695086 0.9999999977911463 4.224615112923249 0.6901650351420924 1.0184984316889591 4.149691175505227e-08 6.956873099117487e-09 0.9861568733648673 0.3287189553391425 1.2151853110977053e-10 9.915357488773124 3.224615115132103 YNQLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YNQLLR 6 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 81650400.0 26894000.0 9478400.0 45278000.0 False True 26040264.691031307 13263174.549203005 33418333.489116017 1.0 0.5093333230891105 1.2833330953285524 24.634240777327122 -6.735402349398458 1.7034882469492079 0.7065107990472808 1.2833502505283396 0.5841388727466578 0.20619213438619868 0.32620328443502133 1.856771848740154 0.09582718197829979 0.23635224960194115 1.8390674195167862e-07 6.735402349398458 0.5768394514810589 YNQLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YNQLLR 6 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 291857900.0 10593000.0 272690000.0 8574900.0 False True 16070355.452033723 224026338.96330565 6880067.256487814 1.0 13.940347469722884 0.4281216602223402 23.93789850381664 -6.65607904128287 1.9874178460334275 9.356806903818434 0.48597146510349243 0.2186891794444089 5.515029649372941 0.49393914799228217 3.7463978053745923 2.2455407536813285 6.109031460066678 2.2076029143144562e-07 6.65607904128287 -8.870835438714941 YNQLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNQLLR 6 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 77635700.0 5664700.0 36420000.0 35551000.0 False True 7759092.672761468 34810843.97516554 27154585.995827906 1.0 4.486458074842961 3.499711517965871 22.887456526757227 -10.561917867084231 11.898072080109515 0.9999816436547599 3.9930847964044163 0.9246293700269065 0.40283759496617494 0.00019615492219444855 7.221980288400428e-06 0.39004810834367865 0.13001527471085372 2.742092702057656e-11 10.561917867084231 2.993103152749656 YNQLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YNQLLR 6 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 36475800.0 26894000.0 6489900.0 3091900.0 False True 22363552.606211796 6454937.620555711 3738401.9946696367 1.0 0.2886365030734321 0.16716494290943926 24.414646052761398 -13.999999999999998 0.24866856284190686 5.914197880910249 0.11770081166726323 0.9995402046789666 0.007876678876201762 13.945605092639719 0.15779775796967424 34.20513792299051 0.05647646574040555 1.0000000000000041e-14 13.999999999999998 -5.796497069242986 YNQLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNQLLR 6 0 P06733;A0A2R8Y6G6;P06733-2 P06733;P06733-2 ENO1 Alpha-enolase 0 34227300.0 10593000.0 8929300.0 14705000.0 False True 13712847.31924718 8432376.605514472 12028840.886041619 1.0 0.6149252893437306 0.8771949840904367 23.70902482590909 -10.074011161473628 5.283174229583458 1.0000032551463036 0.7460601367167567 0.5555522942039091 0.10707115452196564 4.105362691585362e-06 7.193322669793165e-07 0.10367252797257373 0.03455706652673286 8.433130841347564e-11 10.074011161473628 -0.25394311842954687 YNSEVVDK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 YNSEVVDKK 9 1 O43847-2;G3V1R5;O43847 O43847-2 NRD1 Nardilysin 1 5726200.0 2196700.0 2172100.0 1357400.0 True False 3332554.500281549 1784471.78430524 1089109.2950304444 1.0 0.5354666470284222 0.32680914743882855 21.66819703852979 -12.327085292058596 0.12791362402743622 2.4775156675587704 9.184025238268475e-16 0.9997085980485368 0.004803100783279672 6.350050572628512 0.09353569058661906 2.719657353368233 0.2567390111519093 4.708848391951734e-13 12.327085292058596 -2.4775156675587695 YNSQTAK(ub)DSIFEPAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNSQTAKDSIFEPAK 15 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISU1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 7328300.0 2237300.0 2783300.0 2307700.0 True False 2933121.966044016 2368042.489218425 2068921.3410214963 1.0 0.8073453871446984 0.7053649200315759 21.48400563228689 -13.999999998736302 0.07948963236594296 2.04207688053726 0.39793278173696595 0.9998887771339774 0.0012884005307149777 12.263595040098998 0.07918014355868085 2.2524013749360656 0.27937734404490255 1.0000000029097732e-14 13.999999998736302 -1.6441440988002942 YNSQTAK(ub)DSIFEPAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YNSQTAKDSIFEPAK 15 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISU1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 4958900.0 1022000.0 1563400.0 2373500.0 True False 989557.1694145177 2187673.7730232975 1751809.14652628 1.0 2.2107603690220934 1.7702960482442436 19.916423532541614 -10.161874847319565 4.899517819706297 0.9999224721528113 1.990528208636162 0.8708505223669071 0.17981880597822758 0.00015229389128668713 2.6051454611636173e-05 0.17412230015571808 0.05803627007257305 6.888507771078373e-11 10.161874847319565 0.9906057364833507 YNSQTAK(ub)DSIFEPAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNSQTAKDSIFEPAK 15 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISU1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 5605600.0 2237300.0 0.0 3368300.0 True False 3064490.2707591234 0.0 2572776.9123160266 1.0 0.0 0.8395448133299861 21.547215693809783 -9.671635848516885 11.401940370377698 0.9999999995428299 0.419772406664993 0.3890762580594156 0.34274273480976986 0.0 0.0 0.33185922598795586 0.11061974199598526 2.1299242171352654e-10 9.671635848516885 -0.5802275928778369 YNSQTAK(ub)DSIFEPAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YNSQTAKDSIFEPAK 15 1 P55265;P55265-4;P55265-5;P55265-3;P55265-2;A0A3B3IRQ9;A0A3B3ISU1 P55265 ADAR Double-stranded RNA-specific adenosine deaminase 1 5295800.0 1022000.0 2777700.0 1496100.0 True False 849838.28227666 2762735.9787697187 1808927.592815178 1.0 3.2508961250469133 2.1285550798784705 19.69682880797589 -8.946188704254896 11.34710412482277 0.9999857620444511 2.6897256025406904 0.7513790729755413 0.4581938130938351 0.0 0.0 0.44364425182289485 0.14788141727429827 1.1319084335479457e-09 8.946188704254896 1.6897398404962392 YNSWPSSLQELLRPTFPGVIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YNSWPSSLQELLRPTFPGVIR 21 1 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 353812000.0 163930000.0 38002000.0 151880000.0 False True 158726131.88074544 53176396.77781201 112098071.6976665 1.0 0.3350197988681829 0.706235768297361 27.241964424960667 -10.712745514735754 6.944911875465694 1.004849710042174 0.5206277835830974 0.6897752445583551 0.1515482849123476 0.011426172132168963 0.0004726069854374444 0.1473336708191918 0.04891199863431825 1.9375569893389154e-11 10.712745514735754 -0.4842219264590767 YNSWPSSLQELLRPTFPGVIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YNSWPSSLQELLRPTFPGVIR 21 1 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 149234000.0 42461000.0 31395000.0 75378000.0 False True 64416441.314906456 25792316.95974538 60479505.260648996 1.0 0.400399594160394 0.9388830557246816 25.940925625473238 -10.490850624631875 8.987896913403954 1.0000087660433967 0.6696413249425409 0.33415018828674825 0.21983495262668368 3.861657399967579e-05 2.187353731280028e-06 0.21285991962277376 0.07095142586978691 3.229604751627681e-11 10.490850624631875 -0.3303674411008558 YNSWPSSLQELLRPTFPGVIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YNSWPSSLQELLRPTFPGVIR 21 1 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 356916000.0 163930000.0 87246000.0 105740000.0 False True 136315058.33034524 86775988.48102495 127849745.1134795 1.0 0.6365840248604996 0.9378989135862675 27.022369700394943 -10.003808633935488 6.750603537396089 1.00000004008612 0.7872414692233829 0.39931648011982424 0.12301128821360646 7.42473515960856e-08 1.0910794386309813e-08 0.11910518984672583 0.03970172255390116 9.912686379635706e-11 10.003808633935488 -0.21275857086273708 YNSWPSSLQELLRPTFPGVIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNSWPSSLQELLRPTFPGVIR 21 1 Q9NYU2-2;Q9NYU2 Q9NYU2-2 UGGT1 UDP-glucose:glycoprotein glucosyltransferase 1 0 95927000.0 42461000.0 31415000.0 22051000.0 False True 54966601.53144102 29666727.63399563 18037944.262366783 1.0 0.5397227917943261 0.3281618975851916 25.712051947565687 -11.841193938990937 0.13137147739359342 2.2890519998530303 1.7303325944902225e-20 0.9997114665001381 0.004764166235439227 5.079925942654882 0.08934333796369709 2.07445094223479 0.24636905690807265 1.4414715027784389e-12 11.841193938990937 -2.2890519998530303 YNVLGAETVLNQMR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNVLGAETVLNQMR 14 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 11619600.0 2215500.0 6360500.0 3043600.0 False True 2904541.954932523 5411538.193034815 2728677.4682727563 1.0 1.8631296352407254 0.9394519034710063 21.469879238478907 -6.661375289015195 1.9675527906957608 1.5549341393737912 0.9432521517477765 0.24169247394080817 0.3673761115377853 0.48116572585243605 3.582095326526663 0.15076043604928235 0.4074373521916665 2.180844553485759e-07 6.661375289015195 -0.6116819876260147 YNVLGAETVLNQMR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YNVLGAETVLNQMR 14 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 12937300.0 5265600.0 2292600.0 5379100.0 False True 5098446.410243713 3208047.1357510593 3970152.3404590315 1.0 0.6292205267285942 0.7786984545884934 22.281626267840977 -10.243810572106137 6.561769903877394 1.000003231540944 0.7039594906585438 0.8394817617115924 0.061024108510884724 2.884973278373291e-06 3.3243699405210886e-07 0.05908698423113403 0.019695446331650865 5.704130172675309e-11 10.243810572106137 -0.29604374088240015 YNVLGAETVLNQMR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNVLGAETVLNQMR 14 0 Q1KMD3;H3BQZ7 Q1KMD3 HNRNPUL2;HNRNPUL2-BSCL2 Heterogeneous nuclear ribonucleoprotein U-like protein 2 0 15560700.0 2215500.0 5744200.0 7601000.0 False True 3034630.2216362823 5490402.250470775 5805800.3475088775 1.0 1.8092491834179167 1.9131821419673238 21.533089300001798 -11.090779949570072 0.37043308973594563 1.2700361822873755e-12 1.9263552994218287 0.9994606308318926 0.009479985887531822 2.9949088632807075 0.18445117067210046 2.54727494883211 0.028938380613758457 8.113720636438179e-12 11.090779949570072 1.9263552994205586 YNVPFLTFINK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNVPFLTFINK 11 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 34942000.0 10523000.0 11771000.0 12648000.0 False True 13795754.904876964 10014812.68299863 11339306.288183011 1.0 0.7259343727147742 0.8219417035434886 23.717721067457564 -10.878304352225465 10.485075234028594 1.0119740059529168 0.7739380381291314 0.8808444436355675 0.039194828682821176 0.010662429677241752 0.00012375391899499053 0.03688320975185422 0.012650076562168273 1.3234137658826337e-11 10.878304352225465 -0.23803596782378533 YNVPFLTFINK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YNVPFLTFINK 11 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 38917500.0 14718000.0 9284500.0 14915000.0 False True 14250785.146225894 12991849.268027876 11008314.059591101 1.0 0.9116584900214127 0.7724707057636391 23.76453807088275 -6.964427661092298 0.3677447964149656 1.0109810764339537 0.6683203334153573 0.9999008504919461 0.0009325747123848958 0.07815574522432132 0.01554817756884246 0.0018411336046417896 0.011835633632674493 1.0853563185702849e-07 6.964427661092298 -0.3426607430185964 YNVPFLTFINK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNVPFLTFINK 11 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 76658000.0 10523000.0 21357000.0 44778000.0 False True 14413637.473382339 20413377.121845435 34202358.63185795 1.0 1.4162543743411622 2.37291653096031 23.780931128980455 -6.957238751397496 0.4727497670402749 0.9753954453997015 2.8531756885296584 0.9996536644892153 0.010696745680192528 0.08070272935544613 0.024891283508852825 0.013296720559067306 0.07894408456557303 1.1034718245565821e-07 6.957238751397496 1.877780243129957 up YNVPFLTFINK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YNVPFLTFINK 11 0 Q96RP9;Q96RP9-2;C9IZ01;F8WAU4 Q96RP9 GFM1 Elongation factor G, mitochondrial 0 30658700.0 14718000.0 7667100.0 8273600.0 False True 12238669.11795291 7625795.81049981 10003571.507195797 1.0 0.6230902835107721 0.8173741287377034 23.544943346317027 -10.090140355531455 4.788338239747337 1.0000123050087897 0.7202322061209812 0.7343803240061644 0.07931604768984626 110313853.16763398 4.502671851466284 14966.239536809326 0.0271519928057389 8.125678675909556e-11 10.090140355531455 -0.2797800988878085 YNVYGYTGQGVFSNVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNVYGYTGQGVFSNVVR 17 0 H0YDJ3;Q13523 H0YDJ3 PRPF4B Serine/threonine-protein kinase PRP4 homolog 0 11949500.0 3226300.0 4474100.0 4249100.0 False True 4229710.543533647 3806581.719905206 3809443.892245287 1.0 0.8999626997466014 0.9006393825386323 22.01212750649985 -10.360693910461235 5.542679573754018 1.0000285246618899 0.9003010411426191 0.9999654359265322 0.00027625459303629734 9.740402068047511e-08 1.1234971861282214e-08 0.0002675588539070853 8.916078651141607e-05 4.358189294319703e-11 10.360693910461235 -0.09972748351927074 YNVYGYTGQGVFSNVVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YNVYGYTGQGVFSNVVR 17 0 H0YDJ3;Q13523 H0YDJ3 PRPF4B Serine/threonine-protein kinase PRP4 homolog 0 6925800.0 4824200.0 2101600.0 0.0 False True 4671058.411633571 2940779.83969922 0.0 1.0 0.6295746232534835 0.0 22.155318055491435 -7.580769993340886 0.6847591294993756 0.9957639216164154 8.966844635227958e-21 0.9870924613986507 0.04689791749346815 0.12102050339195004 0.14573215372485698 0.04221381453578552 0.07688115196071262 2.625608723610876e-08 7.580769993340886 -0.9957639216164154 down YNVYGYTGQGVFSNVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNVYGYTGQGVFSNVVR 17 0 H0YDJ3;Q13523 H0YDJ3 PRPF4B Serine/threonine-protein kinase PRP4 homolog 0 13739900.0 3226300.0 4008700.0 6504900.0 False True 4419150.297479185 3831582.379001817 4968576.592620772 1.0 0.8670405216105607 1.1243284926188177 22.075337568022743 -6.76626041123809 1.5888931164220446 0.9233743039674153 1.125571481274305 0.7160149156224103 0.055985177522543526 0.2725155603607112 1.3571851896149287 0.02778390185517003 0.0663633516469626 1.7129298941409719e-07 6.76626041123809 0.20219717730688969 YNVYGYTGQGVFSNVVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YNVYGYTGQGVFSNVVR 17 0 H0YDJ3;Q13523 H0YDJ3 PRPF4B Serine/threonine-protein kinase PRP4 homolog 0 10850900.0 4824200.0 2705800.0 3320900.0 False True 4011536.0482965335 2691223.3183407495 4015284.8358932724 1.0 0.6708710294361073 1.0009345017847542 21.93572333092571 -10.953720680000858 10.433091869639162 1.0539839755887235 0.8359027656104308 0.2478765574623678 0.13474784833090162 0.08413013478693532 0.0003731857190041499 0.0648720427289845 0.0434896810435721 1.1124469764939371e-11 10.953720680000858 -0.21808120997829272 YNWK(ub)LDEAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YNWKLDEAR 9 1 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 1 79944700.0 2121000.0 6359700.0 71464000.0 True False 3217712.065870243 5224761.8464371 57339109.07621614 1.0 1.6237505841045607 17.819838413885098 21.617603802866437 -6.915030299655728 0.8607708927068997 0.5747403494423 20.154805816127357 0.9926855429521592 0.6659025384709372 0.10118489101196446 0.12141730792132946 0.5591246353983178 1.6029331125414377 1.2161011533060996e-07 6.915030299655728 19.580065466685056 up YNWK(ub)LDEAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YNWKLDEAR 9 1 K7ER00;Q9Y285;Q9Y285-2;K7EPH2;K7ERS0 K7ER00 FARSA Phenylalanine--tRNA ligase alpha subunit 1 26586200.0 2121000.0 7494200.0 16971000.0 True False 2745676.3111605057 7077141.182068744 13882452.13716504 1.0 2.5775584519201655 5.0561138910425285 21.388730124958887 -6.9644757735803955 0.3669380417839972 0.8026565461391425 6.9168772335007205 0.9999019281258895 0.016532907847954137 0.07813930437746079 0.015489930586120148 0.03282934894615831 0.21085449764605715 1.0852360860949957e-07 6.9644757735803955 6.114220687361578 YNWSAK(ub)AK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNWSAKAK 8 1 P61927;D6RG19 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 1 11992800.0 2610900.0 2254700.0 7127200.0 True False 3422915.183991567 1918307.5487517656 6389745.712929947 1.0 0.5604309325931844 1.8667554904117336 21.706794113745907 -6.81596237817322 1.3894060968069566 0.7620679866453387 1.8928444638132491 0.87480866074402 0.19202964796771665 0.19878132907716625 0.7551077857759563 0.10864198647980966 0.25069315524464797 1.5276983931337197e-07 6.81596237817322 1.1307764771679105 YNWSAK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YNWSAKAK 8 1 P61927;D6RG19 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 1 22728200.0 3146000.0 4330200.0 15252000.0 True False 3046131.952033333 6059271.441694691 11257043.649807794 1.0 1.9891690632935477 3.695520688883346 21.538547007019677 -6.9628306486147435 0.3935116621687953 0.8992165195547154 4.847130681212168 0.9998612096026002 0.013116294781186004 0.07870501595128078 0.01750529860492465 0.021993491610649393 0.14332600879694013 1.0893548000415238e-07 6.9628306486147435 3.947914161657453 YNWSAK(ub)AK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNWSAKAK 8 1 P61927;D6RG19 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 1 17945900.0 2610900.0 2533000.0 12802000.0 True False 3576220.2869195044 2421083.684489132 9778431.26546619 1.0 0.6769951206150705 2.7342922082378673 21.7700041752688 -6.866756538631694 1.1510292851547403 0.8204343583486193 2.8476209080881816 0.9613421280177665 0.17761555221883127 0.14000741825752291 0.34870387691768867 0.11997198659232358 0.28256310637113063 1.359075117697795e-07 6.866756538631694 2.0271865497395622 up YNWSAK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YNWSAKAK 8 1 P61927;D6RG19 P61927 RPL37 60S ribosomal protein L37;Ribosomal protein L37 1 18359300.0 3146000.0 6001200.0 9212100.0 True False 2616038.3914308874 5968870.344455063 11138307.518062096 1.0 2.281644781669388 4.257700328308181 21.318952282453953 -6.964796251440876 0.36153174460688114 0.8326752625111337 5.774548497149405 0.9999088841146688 0.012790770355246919 0.07803016285728409 0.015104126384876574 0.026431110323749972 0.16862668830449434 1.0844355558980993e-07 6.964796251440876 4.941873234638272 YNYIEGTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YNYIEGTK 8 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 9227000.0 3060600.0 1083500.0 5082900.0 False True 2963442.9282877357 1516147.2003778545 3751536.0062685553 1.0 0.5116168041926414 1.2659383349205164 21.498842842834726 -6.731907033043854 1.716055894798066 0.7067225056256599 1.2656670826738603 0.5681784597833451 0.20527595227878387 0.33267558392912217 1.9200913401716533 0.09475699209041939 0.2346469202899168 1.8539284408857388e-07 6.731907033043854 0.5589445770482004 YNYSK(ub)CTVVVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YNYSKCTVVVR 11 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 6473700.0 1838200.0 2394600.0 2240900.0 True False 2409898.0011541215 2037335.0140776902 2009033.164230654 1.0 0.8454030058956821 0.833659002691612 21.200540655056088 -13.999999999999998 0.36559467668161666 3.094713836503109 0.8323562975960068 0.9997832588712026 0.0011158871685839212 22.313032265664678 0.19586661011648088 36.55954424679811 0.0033280659065782836 1.0000000000000041e-14 13.999999999999998 -2.2623575389071022 YNYSK(ub)CTVVVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YNYSKCTVVVR 11 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 30428900.0 2006100.0 5796800.0 22626000.0 True False 3043400.3655550675 4762315.749394875 18153961.182671927 1.0 1.5648009388755872 5.965025629929217 21.537252705150586 -6.93059259708314 0.7419116888858074 0.9345348724364246 6.882153852978631 0.9966534145147815 0.12839278130207749 0.09233140944139048 0.07618136540944362 0.11738673587896392 0.3968554154988137 1.1732954943634157e-07 6.93059259708314 5.947618980542206 up YNYSK(ub)CTVVVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YNYSKCTVVVR 11 1 P78527;P78527-2 P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1 6468900.0 1838200.0 1358800.0 3271900.0 True False 2517832.215487161 1298763.7230492854 2499144.606895706 1.0 0.5158261599246378 0.9925778975753398 21.26375071657898 -10.923269089678728 10.656947393961815 1.0373990886408693 0.7542020287499888 0.2616732633672487 0.19463308187157521 0.10826644692317143 0.0007795264237653951 0.11797329687609649 0.0628175570591363 1.193248536329131e-11 10.923269089678728 -0.2831970598908805 YPALHK(ub)PENQDIDWGALEGETR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YPALHKPENQDIDWGALEGETR 22 1 P13796 P13796 LCP1 Plastin-2 1 26639800.0 7328200.0 9805400.0 9506200.0 True False 11117415.16318263 8055549.760060122 7627295.403284521 1.0 0.7245883725506231 0.6860673359166901 23.40631805976017 -13.999999999143647 0.2771202943271938 3.2093719299255783 0.6741379186281787 0.9995988225009923 0.002800049014912031 15.24470045265094 0.16672046600255702 19.05610913501799 0.015449230100023071 1.0000000019718261e-14 13.999999999143647 -2.5352340112973994 YPALHKPENQDIDWGALEGETR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YPALHKPENQDIDWGALEGETR 22 1 P13796 P13796 LCP1 Plastin-2 0 41759300.0 1004100.0 23699900.0 17055300.0 False True 1316384.8237182314 20163967.30148662 15290581.161989829 1.0 15.317684417336205 11.615586025065522 20.328149868513282 -9.681254736299028 8.239692549392943 0.9999632997007855 13.466635221231684 0.9379638584925901 1.5113753399221221 0.0 0.0 1.4633828802795936 0.48779429342653113 2.083268579298265e-10 9.681254736299028 12.466671921530898 YPALHKPENQDIDWGALEGETR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPALHKPENQDIDWGALEGETR 22 1 P13796 P13796 LCP1 Plastin-2 0 41580000.0 10230000.0 3694500.0 27655500.0 False True 9905254.249618888 5169733.116562975 20411694.902783863 1.0 0.5219182654258354 2.060693687248787 23.239762576236682 -6.823265911428154 1.3578773740421457 0.743139743830435 2.0966438037841266 0.8916881333742073 0.21162824018142637 0.18927463194087624 0.684867340206699 0.12244947820951976 0.2819836117665631 1.5022218984795812e-07 6.823265911428154 1.3535040599536916 up YPALHKPENQDIDWGALEGETR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPALHKPENQDIDWGALEGETR 22 1 P13796 P13796 LCP1 Plastin-2 0 46210500.0 1004100.0 23379100.0 21827300.0 False True 1375342.90478221 22346134.057654906 16672141.287354346 1.0 16.247681927143464 12.122170572432214 20.391359930036174 -9.205306472286475 9.184974644044141 0.9999998020200656 14.184926249800352 0.9315948930487479 1.6842329578958668 0.0 0.0 1.6307515492455082 0.5435838497485027 6.232948344758217e-10 9.205306472286475 13.184926447780287 YPASTVQILGAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YPASTVQILGAEK 13 0 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 0 1151900.0 1151900.0 0.0 0.0 False True 1510152.0550154683 0.0 0.0 1.0 0.0 0.0 20.526262389054935 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 YPASTVQILGAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPASTVQILGAEK 13 0 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 0 8776400.0 1151900.0 3484800.0 4139700.0 False True 1577788.558927028 3330830.0133074373 3161988.1197977206 1.0 2.1110750198192347 2.004063283326141 20.589472450577826 -10.188072676970174 5.9898570840075 0.9999855133494772 2.057569151572697 0.9923794849870755 0.04368735848290856 8.451961804711933e-06 1.1456849026408331e-06 0.04230068114461182 0.014100034320336595 6.485258969603242e-11 10.188072676970174 1.0575836382232198 YPASTVQILGAEK(ub)ALFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPASTVQILGAEKALFR 17 1 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 1 14760400.0 3475900.0 5251800.0 6032700.0 True False 3365559.457111464 7348871.1277752025 4452554.892879324 1.0 2.183551121715279 1.3229761499149946 21.68241491336104 -10.227101837080555 4.938204946462912 0.999885127130203 1.75326363581603 0.5053275877918373 0.351328261056544 0.00044439263899945003 6.955318139484592e-05 0.34022341036886267 0.11339070867655922 5.927863066838641e-11 10.227101837080555 0.753378508685827 YPASTVQILGAEK(ub)ALFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YPASTVQILGAEKALFR 17 1 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 1 36337300.0 7071000.0 4648300.0 24618000.0 True False 10727223.959343934 3818774.5476663304 19752241.509547267 1.0 0.35598907621761655 1.841319020131215 23.354773441307206 -6.788866842523424 1.5009062812411775 0.6395368070384873 1.8566183534317962 0.7976324604843357 0.2735843485800379 0.2370360155309201 1.0549154189924341 0.14348673094784065 0.3362099330769489 1.626047235850665e-07 6.788866842523424 1.217081546393309 YPASTVQILGAEK(ub)ALFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPASTVQILGAEKALFR 17 1 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 1 19440900.0 3294000.0 7251500.0 8895400.0 True False 4511880.817002895 6931104.75249624 6794489.726513681 1.0 1.5361896808924047 1.5059107281621533 22.105297528242208 -10.11638928727284 4.797477614764068 0.9999699553335436 1.5210502045316137 0.9974736973930641 0.012361330704106334 3.972662969296712e-06 7.317001476499403e-07 0.011969495693616874 0.003989602327373443 7.649106587994747e-11 10.11638928727284 0.5210802491980701 YPASTVQILGAEK(ub)ALFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YPASTVQILGAEKALFR 17 1 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 1 11934100.0 3475900.0 3491600.0 4966600.0 True False 2890364.8584789014 3472790.0577716613 6005093.097036203 1.0 1.201505771004727 2.077624587574205 21.462820188795316 -6.942964599119982 0.6313906470487005 0.9904421747740937 2.3360181016238633 0.998526892629024 0.01795435852778449 0.08644000474836089 0.04864528778357969 0.017898022385692755 0.07447715732509877 1.1403427371445234e-07 6.942964599119982 1.3455759268497696 up YPASTVQILGAEK(ub)ALFR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YPASTVQILGAEKALFR 17 1 A0A494C128;O00567;H0YDU4;H0Y653 A0A494C128 NOP56 Nucleolar protein 56 1 26196800.0 7071000.0 4013800.0 15112000.0 True False 9153548.890247965 3790428.5015862356 12361771.062214272 1.0 0.4140938718997277 1.3504894342547613 23.125899763399655 -6.737532631058209 1.6957629836083716 0.6503975240413341 1.3507457204288702 0.5938175312023419 0.24619076512333393 0.3222903206740826 1.8187715761536327 0.11489836401338084 0.282713916511899 1.8300685974986695e-07 6.737532631058209 0.7003481963875361 YPDENGFDAFLK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YPDENGFDAFLKK 13 1 O43847-2;G3V1R5;O43847;F5H7V1 O43847-2 NRD1 Nardilysin 1 10741000.0 4043900.0 2818400.0 3878700.0 True False 5234908.267186224 2661553.562427283 3172816.3988228184 1.0 0.5084241072781728 0.6060882515766058 22.3197328259387 -9.943158155941287 5.7791673721999075 1.0000003455306743 0.5572561794271357 0.9647905223013754 0.039871219950516054 1.774994273366287e-07 3.2450267194519606e-08 0.038605172627631 0.012868380904954835 1.1398346212317225e-10 9.943158155941287 -0.4427441661035386 YPDSILEHQIQVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YPDSILEHQIQVR 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3ISC1 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 3987500.0 1863300.0 2124200.0 0.0 False True 2442804.3442228674 1807277.6400667466 0.0 1.0 0.739837246622262 0.0 21.22010688527346 -7.352541777665436 0.7867182781751323 0.9894894013902014 7.590994223300652e-23 0.9878012788731277 0.04678730685689892 0.10912019559615566 0.1379478926554295 0.040197108983864895 0.07158880403450596 4.440769406058328e-08 7.352541777665436 -0.9894894013902014 down YPDSILEHQIQVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPDSILEHQIQVR 13 0 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3ISC1 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 4006800.0 1863300.0 0.0 2143500.0 False True 2552212.363789157 0.0 1637249.4467682254 1.0 0.0 0.641502043481003 21.28331694679635 -10.263899682174925 7.356967283129562 1.0000026095344734 0.32075102174050163 0.5991759690939595 0.2618921125801942 1.1209836421061393e-05 1.1212085994657907e-06 0.25357692200507204 0.08452531587718086 5.446284422166188e-11 10.263899682174925 -0.6792515877939718 YPDSILEHQIQVRPFNALK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPDSILEHQIQVRPFNALK 19 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3ISC1 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 16122200.0 6534300.0 3892200.0 5695700.0 False True 6326872.223194992 5446375.757554856 4203825.302662624 1.0 0.8608322667854518 0.6644397348900061 22.593061028963184 -6.966251702430999 0.3358791455007211 1.0223445459618183 0.49644132772315186 0.9999366671338868 0.0010954645974298315 0.07753876001383903 0.013376289653579178 0.00280871366416956 0.01705102814397221 1.0808073702515682e-07 6.966251702430999 -0.5259032182386665 YPDSILEHQIQVRPFNALK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YPDSILEHQIQVRPFNALK 19 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3ISC1 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 29626800.0 4775800.0 13107000.0 11744000.0 False True 7245237.757747811 10767953.444541587 9422793.252421934 1.0 1.486211192038067 1.3005499015329784 22.7886016029705 -10.17317525036238 4.530107841269542 0.999930697014914 1.393380546790554 0.8568523482881993 0.07579590448106438 53142753.267769955 5.201685447708624 39171.88683529327 0.02594695415266413 6.711579666572218e-11 10.17317525036238 0.39344984977564 YPDSILEHQIQVRPFNALK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPDSILEHQIQVRPFNALK 19 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3ISC1 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 21867500.0 3398400.0 6243100.0 12226000.0 False True 4654880.318306806 5967259.198829108 9338470.60237383 1.0 1.2819361166732801 2.00616771298014 22.150312644432642 -6.954877596500095 0.5024545106060311 0.985799398289193 2.3336716930201513 0.9995305350925707 0.009182289889177079 0.08158431790842344 0.028299492333803633 0.010719394697930642 0.05974807089271285 1.1094874741135317e-07 6.954877596500095 1.3478722947309583 up YPDSILEHQIQVRPFNALK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YPDSILEHQIQVRPFNALK 19 1 A0A3B3IU45;P33991;A0A3B3IT92;A0A3B3IS57;E5RG31;A0A3B3ITP6;A0A3B3ISC1 A0A3B3IU45 MCM4 DNA replication licensing factor MCM4 0 18264700.0 6534300.0 4630800.0 7099600.0 False True 5433559.968571799 4605852.961258166 8584093.535158485 1.0 0.8476676410859243 1.5798286178508485 22.37346630439746 -6.8524167053819225 1.2233260806933373 0.9185069280913606 1.6104977772654316 0.9437509847695613 0.07481019263684034 0.154822504847616 0.4446399536363864 0.04781975040124199 0.11084547561218995 1.4046990691165843e-07 6.8524167053819225 0.691990849174071 YPEDK(ub)ITPENLPQILLQLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YPEDKITPENLPQILLQLK 19 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 1 71538000.0 11557000.0 24503000.0 35478000.0 True False 17532813.929873846 20130248.207187176 28465757.74944023 1.0 1.148147028064195 1.6235704013796632 24.063554224306746 -6.949926446131938 0.5596487489858072 0.9937706415899571 1.8006544082615294 0.9991955109043229 0.0075447583026796005 0.0835152590402359 0.03608443892527752 0.00809098510443498 0.03951757012280987 1.122208499973483e-07 6.949926446131938 0.8068837666715724 YPEDK(ub)ITPENLPQILLQLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YPEDKITPENLPQILLQLK 19 1 P43243;A8MXP9;A0A0R4J2E8;D6REM6;D6R991 P43243 MATR3 Matrin-3 1 56859000.0 11557000.0 13215000.0 32087000.0 True False 14960764.322528047 12479573.633081388 26247495.240422755 1.0 0.8341534806673974 1.754422078616602 23.834680546399195 -6.860263851543957 1.1842705675036609 0.9099434849160833 1.7992387346376357 0.9539689676832749 0.08592515476856931 0.14653722428584887 0.39035287983895284 0.05657993139931937 0.13212544075106955 1.379545879776744e-07 6.860263851543957 0.8892952497215524 YPENFFLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YPENFFLLR 9 0 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62140;E7ETD8;C9J9S3;C9JP48;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 0 6959800.0 1583700.0 2037800.0 3338300.0 False True 2076246.0365726158 1733768.1832821872 2992884.7392347693 1.0 0.835049484859811 1.4414884780106811 20.98554598349738 -6.834248272432402 1.3088726945296478 0.9120878360233196 1.4592636844416822 0.9140975043629684 0.07503550053656269 0.17562695913662735 0.5869208196091794 0.04499134777400625 0.10354352274293349 1.4647102729922183e-07 6.834248272432402 0.5471758484183626 YPENFFLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPENFFLLR 9 0 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62140;E7ETD8;C9J9S3;C9JP48;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 0 4962100.0 1795900.0 1104800.0 2061400.0 False True 1738890.1375259606 1545952.4014558885 1521457.4993255823 1.0 0.8890454710700827 0.8749589559983734 20.72973535587707 -13.999999999999986 0.2910077884096562 1.961542576926985 0.8711591611856561 0.9996297077200688 0.0010760745659409037 16.026058308216243 0.17109428801313095 9.230642056413254 0.0052960889067552525 1.0000000000000327e-14 13.999999999999986 -1.090383415741329 YPENFFLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPENFFLLR 9 0 P36873;P36873-2;F8VYE8;F8W0W8;F8VR82;A0A087WYY5;P62140;E7ETD8;C9J9S3;C9JP48;P62136;P62136-2;P62136-3;E9PMD7 P36873;P62140;P62136 PPP1CC;PPP1CB;PPP1CA Serine/threonine-protein phosphatase PP1-gamma catalytic subunit;Serine/threonine-protein phosphatase;Serine/threonine-protein phosphatase PP1-beta catalytic subunit;Serine/threonine-protein phosphatase PP1-alpha catalytic subunit 0 6783800.0 1583700.0 2500200.0 2699900.0 False True 2169236.6878832653 2389732.896944229 2062239.2261859216 1.0 1.1016469112349945 0.95067506358573 21.048756045020273 -6.725287425386589 1.7401768461806153 1.0614865654568642 0.9508347479273831 0.5374722256122432 0.04274777567416959 0.34510403323731065 2.045020952363958 0.01948400501094272 0.04861267992914185 1.882402862627791e-07 6.725287425386589 -0.11065181752948106 YPGHLAAITLSR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YPGHLAAITLSR 12 0 Q9H9F9 Q9H9F9 ACTR5 Actin-related protein 5 0 4863600.0 1387900.0 1606800.0 1868900.0 False True 1819550.3404427196 1367071.7032573454 1675524.1557546828 1.0 0.7513239248575665 0.9208451772469272 20.79515053526188 -10.066740830134776 4.882838065775946 1.0000045463879403 0.836084551258243 0.5548846867396509 0.06920676149066951 96030501.94292179 1.390034307196357 4908.644949231567 0.02369131524938031 8.575494443435085e-11 10.066740830134776 -0.16391999512969735 YPGK(ub)MEGLFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPGKMEGLFR 10 1 J3KNZ9;Q9HAH7;Q9HAH7-1 J3KNZ9 FBRS Probable fibrosin-1 1 12348400.0 3435700.0 5258200.0 3654500.0 True False 3326635.5841070954 7357826.681150764 2697276.8173500234 1.0 2.2117922132206385 0.8108122303014448 21.665632404346702 -6.677974472049217 1.909565449337702 1.768135501386437 0.8162901212838581 0.31464673798269993 0.513820569291423 0.4430502454083296 3.1218703045664697 0.21607436556420478 0.5712640711764567 2.099063263521451e-07 6.677974472049217 -0.9518453801025789 YPGK(ub)MEGLFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YPGKMEGLFR 10 1 J3KNZ9;Q9HAH7;Q9HAH7-1 J3KNZ9 FBRS Probable fibrosin-1 1 10931100.0 3435700.0 4616700.0 2878700.0 True False 2856936.777316942 4591828.9207567945 3480622.8603950595 1.0 1.6072560503313469 1.218305875030194 21.44603767978098 -10.324514167901915 6.0313412333762235 0.9999651973277275 1.4127809626807581 0.6002756446540685 0.15878824414231713 7.431968282200706e-05 8.323498065731592e-06 0.15375898351311854 0.051248685428059125 4.7368085512689154e-11 10.324514167901915 0.41281576535303066 YPGSTFMDHVLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YPGSTFMDHVLR 12 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 21548200.0 6537000.0 5944900.0 9066300.0 False True 8570070.304398052 5057944.093038701 8128206.246090576 1.0 0.5901870012014987 0.948441022930615 23.030875608830023 -10.200133700324756 7.731952900692975 1.0000001508317118 0.7693140120660569 0.35601841769992304 0.1462565919227154 3.803466016975633e-07 3.9300227237442834e-08 0.14161242904473362 0.04720411206581091 6.307631301361202e-11 10.200133700324756 -0.2306861387656549 YPGSTFMDHVLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPGSTFMDHVLR 12 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 20592380.0 4096500.0 3651880.0 12844000.0 False True 3966458.8498107344 5110094.728302613 9479771.088259324 1.0 1.2883266716725044 2.389983470699984 21.919420151090435 -6.945928082235486 0.6018903606787136 0.9876411852867725 2.7472465807897803 0.9988417543006255 0.020384587913056817 0.0851631981950284 0.043055178678447076 0.020882753007339078 0.09263788878831782 1.1325879006082394e-07 6.945928082235486 1.7596053955030078 up YPGSTFMDHVLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPGSTFMDHVLR 12 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 33189000.0 6537000.0 12885100.0 13766900.0 False True 8953905.555782603 12315793.676672315 10515441.758205486 1.0 1.3754661136355788 1.1743972161303862 23.094085670352914 -10.147180379809154 4.144596103853446 0.999931512308071 1.2749316647492155 0.7137019338167908 0.08208603409594331 28702944.167748228 3.4300136637394116 21990.608448599953 0.02810023276571757 7.125570153266752e-11 10.147180379809154 0.2750001524411445 YPGSTFMDHVLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YPGSTFMDHVLR 12 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 17865000.0 4096500.0 8298600.0 5469900.0 False True 3406421.2557204855 8253893.794656875 6613630.800039932 1.0 2.423039658056358 1.9415187681011272 21.69982542652471 -10.015983859506324 6.526802560458245 0.9999995531386334 2.182279213078752 0.8893561827581773 0.1965800801468944 1.2782432932618436e-06 1.9250802331201186e-07 0.1903379150488669 0.06344594805041513 9.638648448604657e-11 10.015983859506324 1.1822796599401184 YPGYMNNDLIGLIASLIPTPR ddPTM_RPMI8226_Bortezomib_8h_R1 2 YPGYMNNDLIGLIASLIPTPR 21 0 P23258;Q9NRH3 P23258 TUBG1;TUBG2 Tubulin gamma-1 chain;Tubulin gamma-2 chain 0 1203280000.0 618840000.0 328790000.0 255650000.0 False True 938825523.264095 270114855.6520052 205120665.44462436 1.0 0.2877157138984396 0.21848646032913954 29.80628182314362 -13.999999999999998 0.3296138647945099 8.735676861475152 0.2061705136212255 0.9997140399817983 0.0059731402142660685 18.790656861460995 0.18356771506080222 100.74863358214492 0.022216697618828503 1.0000000000000041e-14 13.999999999999998 -8.529506347853927 YPHLQVIGGNVVTAAQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YPHLQVIGGNVVTAAQAK 18 0 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 13330400.0 3171900.0 4228900.0 5929600.0 False True 4158391.6167232897 3597964.604123093 5316061.872739561 1.0 0.865229861866209 1.2783937547778357 21.987594199790806 -6.818851842883596 1.3766983932808876 0.927270040498128 1.2872019315488727 0.881727969085524 0.05916471998441631 0.19499528049390893 0.7264811346502652 0.03377261046216689 0.07787044396430164 1.5175679889344456e-07 6.818851842883596 0.35993189105074475 YPHLQVIGGNVVTAAQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPHLQVIGGNVVTAAQAK 18 0 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 10880200.0 2595700.0 1223500.0 7061000.0 False True 2513300.9243143457 1712049.9304682123 5211512.274540576 1.0 0.681195758894362 2.0735727362064016 21.261151988662302 -6.8464893262368065 1.2519835615571033 0.8302643921081699 2.125557298415994 0.9350348379194362 0.1518141404469617 0.16135596235041355 0.4884847187287574 0.09496777341905903 0.21931507895791355 1.4240022442725006e-07 6.8464893262368065 1.2952929063078238 up YPHLQVIGGNVVTAAQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPHLQVIGGNVVTAAQAK 18 0 A0A3B3IRL5;P20839;P20839-3;P20839-7;P20839-5;P20839-6;C9J381;P20839-2;P20839-4 A0A3B3IRL5;P20839 IMPDH1 Inosine-5-monophosphate dehydrogenase 1;Inosine-5-monophosphate dehydrogenase 0 10333800.0 3171900.0 2929200.0 4232700.0 False True 4344637.147374454 2799778.258430944 3233023.435192841 1.0 0.6444216544350321 0.7441411849886286 22.050804261313697 -10.197114123171799 7.719906794831562 1.0000001936946823 0.694281419711831 0.9261013394171451 0.04071032787436473 1.35709078494314e-07 1.4151803222013695e-08 0.03941763013801372 0.013139201823004858 6.351640025941996e-11 10.197114123171799 -0.3057187739828513 YPHYFPLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPHYFPLLK 9 0 P52888;K7EP46 P52888 THOP1 Thimet oligopeptidase 0 0.0 0.0 0.0 0.0 False True 0.0 0.0 0.0 0.0 YPIEHGIITNWDDMEK ddPTM_RPMI8226_Bortezomib_1h_R1 2 YPIEHGIITNWDDMEK 16 0 P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P68133 ACTA1;ACTC1;ACTG2;ACTA2 Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 835899600.0 132637100.0 387593700.0 315668800.0 False True 173888522.5595036 329766230.78840923 283006420.684945 1.0 1.8964232137607888 1.6275163910723431 27.373587470392387 -10.155426147090157 5.024130745886641 0.9999564816056667 1.7619698024178876 0.9145707318781396 0.1097807506612375 5.351819777374763e-05 8.996698541994825e-06 0.10630079856689008 0.03543158491976667 6.991556198909514e-11 10.155426147090157 0.7620133208122208 YPIEHGIITNWDDMEK ddPTM_RPMI8226_Bortezomib_2h_R1 2 YPIEHGIITNWDDMEK 16 0 P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P68133 ACTA1;ACTC1;ACTG2;ACTA2 Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 784868200.0 214797400.0 109382300.0 460688500.0 False True 207978774.11115226 153059222.8111589 340020361.4912459 1.0 0.7359367486672359 1.634880111897983 27.631861056469305 -6.828048858836956 1.3365230703487818 0.8586951804996676 1.6581327282911207 0.901922188706415 0.11814680059248492 0.18323863871755752 0.6408198652308528 0.06941874264694792 0.15977681994865078 1.4857684815088214e-07 6.828048858836956 0.799437547791453 YPIEHGIITNWDDMEK ddPTM_RPMI8226_Bortezomib_8h_R1 2 YPIEHGIITNWDDMEK 16 0 P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P68133 ACTA1;ACTC1;ACTG2;ACTA2 Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 2066761800.0 70527000.0 1929409800.0 66825000.0 False True 106994615.21434751 1585091546.6424277 53617009.459562056 1.0 14.814685238756518 0.5011187652027954 26.672962950126802 -6.654258464156984 1.9934553256060634 9.934088608301842 0.5613838557140558 0.21144854476268526 5.890149656190063 0.49818134566723604 3.7994031684703335 2.3924179212438896 6.525406341589449 2.216876684637749e-07 6.654258464156984 -9.372704752587786 YPIEHGIITNWDDMEK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 YPIEHGIITNWDDMEK 16 0 P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P68133 ACTA1;ACTC1;ACTG2;ACTA2 Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 788212900.0 132637100.0 310253500.0 345322300.0 False True 181676620.2528519 296545474.4988746 263764284.8760114 1.0 1.6322709773340773 1.4518339481927418 27.43679753191528 -10.188579859428238 4.450147355881967 0.9998672294079181 1.5420524627753034 0.9232710628073486 0.073663108723653 39100873.68191354 13.214645529589712 53195.99497641246 0.02695793743497995 6.477689705314334e-11 10.188579859428238 0.5421852333673853 YPIEHGIITNWDDMEK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 YPIEHGIITNWDDMEK 16 0 P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P68133 ACTA1;ACTC1;ACTG2;ACTA2 Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 382179400.0 214797400.0 124740100.0 42641900.0 False True 178613555.23825085 124068100.32232864 51558124.13613095 1.0 0.6946174950542552 0.2886573981877136 27.41226633190358 -7.152011435052716 0.35222896479671345 1.043680968878992 1.0560147643432393e-11 0.9998712206320135 0.003306495284653831 0.08238147899828503 0.018150582968046503 0.007649772831965022 0.03836191511468874 7.046745145147137e-08 7.152011435052716 -1.0436809688684319 down YPIEHGIITNWDDMEK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 YPIEHGIITNWDDMEK 16 0 P68133;P68032;P63267;P62736;A6NL76;F8WB63;B8ZZJ2;C9JFL5;F6UVQ4;F6QUT6 P68133 ACTA1;ACTC1;ACTG2;ACTA2 Actin, alpha skeletal muscle;Actin, alpha cardiac muscle 1;Actin, gamma-enteric smooth muscle;Actin, aortic smooth muscle 0 273962000.0 70527000.0 125518000.0 77917000.0 False True 91298591.79501054 118532812.96081036 63736905.49593365 1.0 1.298298370548232 0.6981148804467855 26.44408927221925 -6.771542535747859 1.5683653722636144 1.1707540758274693 0.694524375048275 0.7365196135661095 0.12577234258950137 0.26392700651027495 1.2813993380980337 0.0632001019137053 0.15024187409200984 1.692222496361144e-07 6.771542535747859 -0.47622970077919424 YPIEHGIVTNWDDMEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPIEHGIVTNWDDMEK 16 0 C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65 C9JUM1;K7EM38;P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 13243900.0 4133000.0 2144600.0 6966300.0 False True 4001800.1772898166 3000949.963941258 5141617.045479672 1.0 0.74990000274667 1.2848260327085563 21.93221769997853 -6.7795551984375875 1.5374404667653205 0.8583050408144962 1.2890163311324228 0.7658582158125966 0.10574562123899021 0.2512711710379837 1.1730834542261763 0.05417261233510647 0.1278809456755109 1.6612875162003226e-07 6.7795551984375875 0.43071129031792654 YPIEHGIVTNWDDMEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPIEHGIVTNWDDMEK 16 0 C9JUM1;C9JZR7;K7EM38;P60709;A0A2R8Y793;G5E9R0;E7EVS6;A0A2R8YGF8;P63261;I3L3I0;I3L1U9;I3L4N8;I3L3R2;J3KT65 C9JUM1;K7EM38;P60709;P63261 ACTB;ACTG1 Actin, cytoplasmic 1;Actin, cytoplasmic 1, N-terminally processed;Actin, cytoplasmic 2;Actin, cytoplasmic 2, N-terminally processed 0 6353900.0 0.0 0.0 6353900.0 False True 0.0 0.0 4853239.682678154 0.0 YPIFFFGTHETAFLGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPIFFFGTHETAFLGPK 17 0 Q7Z4V5-2;Q7Z4V5;Q7Z4V5-4;Q7Z4V5-3;M0R0J3;Q9Y3E1 Q7Z4V5-2 HDGFRP2;HDGFRP3 Hepatoma-derived growth factor-related protein 2;Hepatoma-derived growth factor-related protein 3 0 5273900.0 2532500.0 1102700.0 1638700.0 False True 2452107.1737204148 1543013.8605045355 1209475.310053767 1.0 0.6292603671818414 0.4932391711976898 21.225590605292492 -13.999999999999998 0.13938759224541078 2.7700243149446213 0.3236573557452726 0.9996053862167593 0.0042541349473724415 11.933469312639925 0.11692819788374646 5.747169112505916 0.15154299357811493 1.0000000000000041e-14 13.999999999999998 -2.4463669591993487 YPIFFFGTHETAFLGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YPIFFFGTHETAFLGPK 17 0 Q7Z4V5-2;Q7Z4V5;Q7Z4V5-4;Q7Z4V5-3;M0R0J3;Q9Y3E1 Q7Z4V5-2 HDGFRP2;HDGFRP3 Hepatoma-derived growth factor-related protein 2;Hepatoma-derived growth factor-related protein 3 0 5681500.0 2532500.0 1241200.0 1907800.0 False True 2105885.958772641 1234513.409241089 2306712.15932945 1.0 0.5862204475500619 1.0953642336234841 21.00599588072677 -6.690540867212462 1.8642532008460233 0.7407217857220116 1.0936277594981392 0.3730608806896585 0.17497994882423643 0.41551074553444006 2.800182842022956 0.07507136706081123 0.19537524247473417 2.039196761687066e-07 6.690540867212462 0.35290597377612754 YPMAVGLNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YPMAVGLNK 9 0 Q9Y3U8;J3QSB5;J3KTD3 Q9Y3U8 RPL36 60S ribosomal protein L36 0 23967600.0 2806600.0 10366000.0 10795000.0 False True 3679479.7791530658 8819433.206351522 9678036.952951882 1.0 2.396923950043166 2.6302731727960604 21.811070375527812 -10.418912271160865 0.37729795895727036 1.014950611602565e-21 2.6611701400580063 0.999166205294002 0.020785992102199218 1.869085928591562 0.17760456130835628 1.9007497408779863 0.06342317797427019 3.811428076532322e-11 10.418912271160865 2.6611701400580063 YPMAVGLNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPMAVGLNK 9 0 Q9Y3U8;J3QSB5;J3KTD3 Q9Y3U8 RPL36 60S ribosomal protein L36 0 10682500.0 3422300.0 1899100.0 5361100.0 False True 3313660.959772308 2657420.5336756655 3956867.0804474503 1.0 0.8019590917527861 1.1941074022006581 21.65999456878237 -6.769393467437166 1.57662188855028 0.8863213948126273 1.1962706381288661 0.7282885273470827 0.08345185465443238 0.2674124651152151 1.3117258916603012 0.04172234067135891 0.09937805534967577 1.70061706434251e-07 6.769393467437166 0.30994924331623885 YPMAVGLNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPMAVGLNK 9 0 Q9Y3U8;J3QSB5;J3KTD3 Q9Y3U8 RPL36 60S ribosomal protein L36 0 21050600.0 2806600.0 8018000.0 10226000.0 False True 3844275.865513152 7663738.248019684 7810829.411080878 1.0 1.993545342770736 2.031807727731384 21.874280437050704 -10.978984078721728 0.5681445144155968 7.406660883278549e-22 2.028015316174393 0.9998819820833652 0.005188843429592428 2.818164539851254 0.2785121380148344 3.7064921830528417 0.0069509018652119565 1.0495809056859037e-11 10.978984078721728 2.028015316174393 YPMPQNLMWQK(ub)DR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YPMPQNLMWQKDR 13 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 31673000.0 6281100.0 15571000.0 9820900.0 True False 8234582.926258935 13247867.495282607 8804727.476724885 1.0 1.6088085594519923 1.0692378175763875 22.97326415000371 -10.24270390041374 5.006113809233373 0.9999451635851055 1.3390231885142103 0.344855865673075 0.22027883295585438 0.0001348540551871659 2.0400190030073628e-05 0.2133184775458288 0.07109468762988501 5.718684005137466e-11 10.24270390041374 0.33907802492910477 YPMPQNLMWQK(ub)DR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPMPQNLMWQKDR 13 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 35648000.0 12244000.0 11959000.0 11445000.0 True False 11855320.922026755 16734291.065361127 8447211.157359703 1.0 1.4115426461606302 0.7125248833766357 23.499031381130983 -6.7471780830440515 1.6604790325136911 1.2428105790627528 0.711444641512127 0.6366745526652005 0.17291346194686846 0.3049861401701128 1.6536108274561094 0.0822968723102316 0.20037520861191935 1.7898717641826187e-07 6.7471780830440515 -0.5313659375506258 YPMPQNLMWQK(ub)DR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPMPQNLMWQKDR 13 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 31864900.0 6281100.0 18160000.0 7423800.0 True False 8603392.410345137 17357631.152910657 5670451.337960315 1.0 2.0175333548704577 0.6590948160334856 23.036474211526603 -6.7062255227370136 1.8085512678814248 1.6279531481533358 0.6626150989895964 0.4471980816284138 0.42904510929289197 0.3827195704106014 2.437756472746744 0.18895295191036346 0.48225871986488483 1.9668646605809737e-07 6.7062255227370136 -0.9653380491637394 YPMPQNLMWQK(ub)DR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YPMPQNLMWQKDR 13 1 Q9NVR0 Q9NVR0 KLHL11 Kelch-like protein 11 1 43761000.0 12244000.0 20746000.0 10771000.0 True False 10181428.501169683 20634237.180241395 13023166.30052286 1.0 2.026654430453531 1.2791099303036608 23.27943665656526 -10.07191828150253 4.453143513252278 0.9999568117150113 1.6528821798257505 0.5042218417899502 0.30518376440311895 70614542.48071866 3.274996670464342 34811.86665360127 0.10447251994185272 8.473868466645477e-11 10.07191828150253 0.6529253681107392 YPNNSMFNEVYGK(ub)NLTSSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPNNSMFNEVYGKNLTSSSK 20 1 E9PD50;Q92540-2;Q92540;Q92540-5;Q92540-4 E9PD50 SMG7 Protein SMG7 1 14047300.0 1299000.0 2124300.0 10624000.0 True False 1257763.9560366517 2972544.0680781505 7841255.686831765 1.0 2.3633560604208705 6.234282393924213 20.262429767051874 -6.952681786063461 0.5285838225565245 0.9383222964783705 7.834615456047008 0.9993952778535927 0.0545213755113114 0.08242643076409382 0.03164160077768149 0.06095456396599816 0.3200472597001998 1.1151112927286281e-07 6.952681786063461 6.896293159568637 YPNNSMFNEVYGK(ub)NLTSSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YPNNSMFNEVYGKNLTSSSK 20 1 E9PD50;Q92540-2;Q92540;Q92540-5;Q92540-4 E9PD50 SMG7 Protein SMG7 1 10210400.0 1299000.0 3219500.0 5691900.0 True False 1080176.0554573198 3202155.914479282 6882049.973627892 1.0 2.964475928068567 6.371229892440268 20.04283504248615 -6.962734884268148 0.3950035031401945 0.8020876186181997 8.65701370710689 0.9998585725165597 0.02638895774183459 0.07873823730689472 0.017624586579524714 0.04388584786279546 0.28598058616462463 1.0895950353140142e-07 6.962734884268148 7.85492608848869 YPPFLPVAFHVLFASSHTPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YPPFLPVAFHVLFASSHTPR 20 0 E7EXA6;Q8WVB6;Q8WVB6-2;A0A0D9SF58;Q8WVB6-3 E7EXA6 CHTF18 Chromosome transmission fidelity protein 18 homolog 0 151135400.0 87056800.0 31002000.0 33076600.0 False True 132071530.3045983 25469450.880268402 26538995.512011196 1.0 0.192845882996342 0.20094410544652555 26.97674426796247 -10.020808203356495 6.900185707633665 1.0000001406588668 0.19689499423929904 0.9999237457228648 0.0033060854710872363 7.159209460151885e-09 1.0161937954431207e-09 0.00320110406504874 0.0010670344975543782 9.532170385040017e-11 10.020808203356495 -0.8031051464195678 YPPFLPVAFHVLFASSHTPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YPPFLPVAFHVLFASSHTPR 20 0 E7EXA6;Q8WVB6;Q8WVB6-2;A0A0D9SF58;Q8WVB6-3 E7EXA6 CHTF18 Chromosome transmission fidelity protein 18 homolog 0 166620200.0 87056800.0 54118400.0 25445000.0 False True 112696743.74608122 51106663.4661031 20814271.087747622 1.0 0.45348837745704806 0.18469274617769418 26.74787059005492 -9.199518838338621 0.24129465887870757 1.3669786498765513 3.4505578623360264e-22 0.999204128683127 0.009569891395743671 0.6270508529258854 0.08729535286026974 0.30261738727480597 0.1173186759767222 6.316567793943999e-10 9.199518838338621 -1.3669786498765513 YPQAVFLEVDVHQCQGTAATNNISATPTFLFFR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YPQAVFLEVDVHQCQGTAATNNISATPTFLFFR 33 0 O43396;K7ER96;K7EML9 O43396 TXNL1 Thioredoxin-like protein 1 0 112908000.0 32167000.0 42929000.0 37812000.0 False True 48799690.72270071 35267984.54419206 30338441.626411688 1.0 0.7227091815929492 0.6216933176647943 25.54036866867511 -13.999999999999998 0.14044271961775942 2.3250977941559157 0.49734516915974086 0.9996011735821572 0.003193981646386625 11.934508109342792 0.11744727961985577 4.332881836357049 0.11119931457794623 1.0000000000000041e-14 13.999999999999998 -1.8277526249961749 YPSLSLHGIEGAFSGSGAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YPSLSLHGIEGAFSGSGAK 19 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 54163300.0 8612300.0 29744000.0 15807000.0 False True 11290808.701631844 25306311.141203884 14171443.27145071 1.0 2.241319626427326 1.2551309340138348 23.42864548673079 -10.287599283797295 4.852569158443024 0.9997387485960918 1.7482252802212828 0.4342320053767994 0.4026098477550233 0.0011383200478968698 0.0001671155932285006 0.3899580310204505 0.12994176961418066 5.157042567589478e-11 10.287599283797295 0.748486531625191 YPSLSLHGIEGAFSGSGAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPSLSLHGIEGAFSGSGAK 19 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 61650000.0 18543000.0 10447000.0 32660000.0 False True 17954362.614925038 14618541.580385309 24105366.221002 1.0 0.8142055440182131 1.3425910313833018 24.09783110203122 -6.81169834752799 1.4074689609102575 0.8989442698354128 1.3521901036399655 0.8641848154325671 0.08065504768127041 0.2045011939989786 0.7981238739465241 0.04505579166011838 0.1041411763300788 1.5427716599750604e-07 6.81169834752799 0.45324583380455274 YPSLSLHGIEGAFSGSGAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPSLSLHGIEGAFSGSGAK 19 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 70128300.0 8612300.0 29952000.0 31564000.0 False True 11796500.048656348 28628621.601981275 24109233.280985434 1.0 2.426874198609625 2.043761554829268 23.49185554825368 -10.174111545616105 5.236258664867967 0.9999414938353157 2.235317876720037 0.932716808294659 0.15640508188050395 0.00010683325016011967 1.6850343382141243e-05 0.15144566397476794 0.05047952311514995 6.697125761547626e-11 10.174111545616105 1.235376382884721 YPSLSLHGIEGAFSGSGAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YPSLSLHGIEGAFSGSGAK 19 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 41271000.0 18543000.0 11157000.0 11571000.0 False True 15419326.094184047 11096895.02650888 13990442.60174081 1.0 0.7196744500198665 0.9073316509609203 23.878236377465495 -10.114145857886692 4.817940604200605 1.0000100618786898 0.8135030509996205 0.5683881926999526 0.07661073148238233 91510187294.5945 16825498426.93896 10560044.853379516 0.026226315780892254 7.688721710501174e-11 10.114145857886692 -0.1865070108790693 YPSLSLHGIEGAFSGSGAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YPSLSLHGIEGAFSGSGAK 19 0 Q96KP4;Q96KP4-2 Q96KP4 CNDP2 Cytosolic non-specific dipeptidase 0 21935000.0 6037100.0 11031000.0 4866900.0 False True 7815144.959032119 10417115.152971677 3981174.1386110787 1.0 1.3329394665843541 0.5094178239150837 22.897841202592264 -6.796970501697447 1.468357563401236 1.1844084291467734 0.4988956655658618 0.8231276338557012 0.14225438634324425 0.22511075511867015 0.9585119248196095 0.07622855773890055 0.17760824880030923 1.5959875467828194e-07 6.796970501697447 -0.6855127635809115 YPSPFFVFGEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YPSPFFVFGEK 11 0 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 0 28897800.0 7342500.0 12301000.0 9254300.0 False True 9626088.604871152 10465738.748922449 8296753.809513922 1.0 1.0872265131266716 0.8619029130186338 23.198518272205174 -6.80171940848467 1.4487195222884015 1.0480215678181364 0.8586526633184243 0.8372018294675445 0.03742951480746645 0.21830207815199174 0.9043274087805823 0.02032299817947099 0.04721862589091762 1.5786308713420108e-07 6.80171940848467 -0.1893689044997121 YPSPFFVFGEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPSPFFVFGEK 11 0 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 0 29460500.0 7342500.0 10214000.0 11904000.0 False True 10057220.67360162 9762711.706818797 9092520.370575674 1.0 0.9707166645397515 0.9040788370530529 23.261728333728065 -6.957444334078829 0.4700765887606117 1.0017587805315202 0.8703045807112447 0.9996633076866192 0.0007364627414747346 0.08062712475662767 0.024603451954188203 0.0009215085456288127 0.005499948787286375 1.1029495959280753e-07 6.957444334078829 -0.1314541998202755 YPSPFFVFGEK(ub)IR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YPSPFFVFGEKIR 13 1 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 1 4135600.0 1091300.0 1935400.0 1108900.0 True False 1430704.868164232 1646645.8641301112 994161.665319904 1.0 1.15093329223305 0.6948754333907692 20.448294666860985 -6.81750921030465 1.3825820543074017 1.0815637108795921 0.6854387317272371 0.8785611175514744 0.06610638493111787 0.19674174155859184 0.739631318874636 0.03757918694705008 0.08667822939239953 1.5222668490483783e-07 6.81750921030465 -0.396124979152355 YPSPFFVFGEK(ub)IR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YPSPFFVFGEKIR 13 1 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 1 73682000.0 22011000.0 17316000.0 34355000.0 True False 33392296.21964637 14225824.509474482 27564719.19166856 1.0 0.42602115218134395 0.8254813927845683 24.99301196787892 -9.986807836924699 5.580643356162729 1.0000008296524867 0.6257512724826229 0.5392428329673237 0.16307896033579836 1.6833760878487224e-06 3.0567459904224986e-07 0.1579008749380623 0.052633508124599174 1.0308421381566828e-10 9.986807836924699 -0.37424955716986386 YPSPFFVFGEK(ub)IR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPSPFFVFGEKIR 13 1 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 1 5020800.0 1091300.0 2225900.0 1703600.0 True False 1494783.1012736035 2127552.377933029 1301244.766743337 1.0 1.423318457453985 0.8705241353308278 20.511504728383876 -6.702033521797389 1.8232247050339843 1.2623258358750387 0.8720805424324802 0.427471893774638 0.17862066613606414 0.39127658782419755 2.5299676869064487 0.07811009389757434 0.20040512538500882 1.9859416229803867e-07 6.702033521797389 -0.3902452934425584 YPSPFFVFGEK(ub)IR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YPSPFFVFGEKIR 13 1 Q08211;Q08211-2 Q08211 DHX9 ATP-dependent RNA helicase A 1 58537000.0 22011000.0 11017000.0 25509000.0 True False 28493673.401675582 10403894.265278677 20866623.744443092 1.0 0.36512997529714336 0.732324802431968 24.76413828997137 -10.723182264852934 7.002713118613521 1.0051995264346367 0.5487273888646885 0.6681966762440965 0.14990666044496584 0.012223192425474491 0.00048318300674973406 0.1457935422363698 0.04838216661574358 1.8915496058717314e-11 10.723182264852934 -0.4564721375699482 YPVESSK(ub)SASPFNLAEKPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YPVESSKSASPFNLAEKPK 19 2 Q5VYK3;J3KN16;R4GMY1 Q5VYK3 ECM29;KIAA0368 Proteasome-associated protein ECM29 homolog 1 21502000.0 2867700.0 8540300.0 10094000.0 True False 4350510.55695243 7016216.739331533 8098916.47564263 1.0 1.6127341026949382 1.8616013843938333 22.052753288621375 -10.770930941145904 0.18200338878515018 1.024476113343996e-21 2.103307494425114 0.9994788211753914 0.008265406992711508 2.7155380565147866 0.09894896698052498 1.3500200033579626 0.17610591395112277 1.6946072451106835e-11 10.770930941145904 2.103307494425114 YPVESSK(ub)SASPFNLAEKPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YPVESSKSASPFNLAEKPK 19 2 Q5VYK3;J3KN16;R4GMY1 Q5VYK3 ECM29;KIAA0368 Proteasome-associated protein ECM29 homolog 1 21470000.0 2867700.0 6207300.0 12395000.0 True False 3712294.1808180055 5861858.29834476 10139237.183440022 1.0 1.5790392713578258 2.7312590785048823 21.823879610713824 -6.960143876388587 0.4334008388898806 0.9558491518240203 3.39888398548319 0.9997754995889186 0.010781704688909655 0.0796497632491933 0.0209416592633263 0.015076300144910279 0.0955968156146136 1.096115006646291e-07 6.960143876388587 2.4430348336591696 YPVGVHFLPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YPVGVHFLPK 10 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 13008100.0 3421100.0 3789400.0 5797600.0 False True 4485095.229979525 3224036.290965513 5197719.966506144 1.0 0.7188334083555749 1.1588873145353196 22.09670718687911 -6.734129302552449 1.7083576533246343 0.831578155439151 1.1588208582540158 0.5782470770411334 0.11816190982145235 0.32853755985294414 1.8802661563336005 0.054773570858133835 0.13527662182241054 1.8444661842652688e-07 6.734129302552449 0.3272427028148648 YPVGVHFLPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPVGVHFLPK 10 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 8721500.0 2480200.0 1199300.0 5042000.0 False True 2401467.4085928407 1678186.7442668767 3721348.9432422565 1.0 0.698817205789282 1.5496145939464618 21.19548479856136 -6.811010803681494 1.4101193624041248 0.8360460033843656 1.5648661412806268 0.8624659016817173 0.13062948151054324 0.2054411801168873 0.8049139347800092 0.07283367347354651 0.1684160713002731 1.5452159996552448e-07 6.811010803681494 0.7288201378962612 YPVGVHFLPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPVGVHFLPK 10 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 11767000.0 3421100.0 3022800.0 5323100.0 False True 4685973.121751239 2889242.700937134 4065893.4126857626 1.0 0.6165726148803364 0.867673225399607 22.159917248402003 -10.146627921718814 5.111856267297147 1.000011196888076 0.7421229201396501 0.5844190236705638 0.10251139498004422 1.3081809936706813e-05 2.183792236194325e-06 0.09926053966771563 0.03308541046268939 7.134640228827744e-11 10.146627921718814 -0.25788827674842596 YPVGVHFLPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YPVGVHFLPK 10 0 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 0 6561500.0 2480200.0 2492000.0 1589300.0 False True 2062396.1914897934 2478575.1013767263 1921615.281907067 1.0 1.2017938704523605 0.9317391536293365 20.975890073995636 -6.706745513533462 1.8074732406421357 1.124473738836643 0.9324505947630706 0.4493520220716064 0.08507975650368922 0.38164216808825585 2.4285062173161105 0.0374935397706691 0.09560520364993788 1.9645110974429242e-07 6.706745513533462 -0.19202314407357246 YPVNSVNILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YPVNSVNILK 10 0 P17987;E7ERF2;E7EQR6 P17987 TCP1 T-complex protein 1 subunit alpha 0 16167800.0 2578900.0 7085300.0 6503600.0 False True 3380962.8741031247 6028200.858283092 5830669.85893635 1.0 1.7829834525710981 1.7245589721191672 21.68900274360297 -10.445341887000957 4.626884843191748 0.997954024961524 1.7537712123455704 0.9955144111437974 0.023851694267236538 0.0005045196293229055 6.0480370826611114e-05 0.023145843218509366 0.007698101222775235 3.586394939021895e-11 10.445341887000957 0.7558171873840465 YPVNSVNILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPVNSVNILK 10 0 P17987;E7ERF2;E7EQR6 P17987 TCP1 T-complex protein 1 subunit alpha 0 13129700.0 4806500.0 1460800.0 6862400.0 False True 4653920.288445084 2044105.0579713641 5064931.572412867 1.0 0.439222189311351 1.088315067404196 22.15001507004384 -6.678247173109166 1.9090229143308755 0.6446144650066339 1.085758561139193 0.3157662833529522 0.2377653633262786 0.44240150289980257 3.1158877627136556 0.10001613838612898 0.264291885802189 2.097745638907071e-07 6.678247173109166 0.441144096132559 YPVNSVNILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPVNSVNILK 10 0 P17987;E7ERF2;E7EQR6 P17987 TCP1 T-complex protein 1 subunit alpha 0 22549900.0 2578900.0 10367000.0 9604000.0 False True 3532389.0221520187 9908951.660915453 7335733.000588768 1.0 2.805169985178664 2.076705865233286 21.75221280512586 -10.467774137654654 5.874855846996836 0.9989237948863415 2.4409379252059753 0.8391482643287251 0.2973942316319648 0.004194286478257417 0.0003799764990188376 0.28810423823141057 0.0959835755307289 3.405852709017981e-11 10.467774137654654 1.4420141303196337 YPVNSVNILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YPVNSVNILK 10 0 P17987;E7ERF2;E7EQR6 P17987 TCP1 T-complex protein 1 subunit alpha 0 7042770.0 4806500.0 1327300.0 908970.0 False True 3996817.7140535843 1320149.5714515774 1099031.424397575 1.0 0.3303001702603739 0.27497661965747594 21.930420345478115 -13.999999999999998 0.35331456626591173 9.40619851216414 0.26766521903085533 0.9997609732271586 0.005094450528870676 20.994383396252534 0.19158590998504435 132.6615204103637 0.016322195331738055 1.0000000000000041e-14 13.999999999999998 -9.138533293133285 YPVNSVNILK(ub)AHGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPVNSVNILKAHGR 14 1 P17987;E7ERF2;E7EQR6 P17987 TCP1 T-complex protein 1 subunit alpha 1 7407100.0 2084500.0 1478900.0 3843700.0 True False 2018328.6884976143 2069432.4823616163 2836919.661471689 1.0 1.0253198570457036 1.4055786243535042 20.944729708412382 -6.920408431472238 0.8216756825066743 0.9917330769570409 1.467481991420446 0.9942940616733769 0.01401313079334253 0.09793179304381659 0.10436769732589737 0.01209999317419214 0.036388864903383285 1.2011342986709924e-07 6.920408431472238 0.47574891446340506 YPVYGVQWHPEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YPVYGVQWHPEK 12 0 Q92820 Q92820 GGH Gamma-glutamyl hydrolase 0 7121000.0 2688600.0 2171700.0 2260700.0 False True 3524780.63643944 1847690.8252202973 2026784.4501656622 1.0 0.5242002313899295 0.5750100954404415 21.74910204397926 -10.738391733573229 10.614623788093999 1.0007528701436827 0.549605163724187 0.9905453615602913 0.02074304013732278 0.0003700646024984116 9.120621525185538e-06 0.02011112430548423 0.006694787416796928 1.8264520134070143e-11 10.738391733573229 -0.45114770641949575 YPVYGVQWHPEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPVYGVQWHPEK 12 0 Q92820 Q92820 GGH Gamma-glutamyl hydrolase 0 4924200.0 1259500.0 1105400.0 2559300.0 False True 1219517.8619154429 1546791.9845848482 1888942.5526457592 1.0 1.2683635335651176 1.5489256956670405 20.21787945833823 -6.970565037867 0.2443134599380453 0.9044962326302394 1.9209515248969384 0.9999864598853703 0.0008246586263682498 0.07611979025378225 0.008371445960284054 0.006506628540136183 0.027146483674774877 1.0701261139362592e-07 6.970565037867 1.016455292266699 YPVYGVQWHPEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPVYGVQWHPEK 12 0 Q92820 Q92820 GGH Gamma-glutamyl hydrolase 0 7163600.0 2688600.0 1369000.0 3106000.0 False True 3682648.076683054 1308513.053322395 2372426.770077956 1.0 0.3553185170223942 0.6442176175071257 21.81231210550215 -10.456725123883105 6.157265751624343 1.000225987086647 0.499768067264852 0.7999002107525544 0.11794256388943958 0.0003660458437386334 3.229760502351362e-05 0.11424780517939569 0.03806579881273362 3.4936136528608326e-11 10.456725123883105 -0.500457919821795 YPYEYEGGHIK(ub)TAVNLPLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 YPYEYEGGHIKTAVNLPLER 20 1 B4DIG0;P30305-3;P30305-2;P30305;P30305-4;G8JLH2 B4DIG0 CDC25B M-phase inducer phosphatase 2 1 24622100.0 6418500.0 5184600.0 13019000.0 True False 6214748.2308092695 7254837.8173318235 9608933.338371871 1.0 1.1673582819278772 1.5461500581368874 22.567264515948636 -6.957555560843565 0.46861522927483945 0.9898592484199097 1.7391415361524358 0.9996685180877539 0.004159601805208648 0.08058616414924008 0.024447383104689975 0.0052238897295495265 0.03126697351928822 1.1026671566794545e-07 6.957555560843565 0.7492822877325261 YPYEYEGGHIK(ub)TAVNLPLER ddPTM_RPMI8226_Bortezomib_8h_R1 1 YPYEYEGGHIKTAVNLPLER 20 1 B4DIG0;P30305-3;P30305-2;P30305;P30305-4;G8JLH2 B4DIG0 CDC25B M-phase inducer phosphatase 2 1 73144000.0 14811000.0 26154000.0 32179000.0 True False 22469369.829139184 21486614.35786528 25818806.545443263 1.0 0.9562624373203638 1.1490667847729488 24.421456327798136 -6.8471031766171 1.2491444161260032 0.9767069877896651 1.1563476065957292 0.9359588472750011 0.02088645520852163 0.16067551221708745 0.48394032360263084 0.013093686982912467 0.03024600097725326 1.4219909204261143e-07 6.8471031766171 0.17964061880606408 YPYEYEGGHIK(ub)TAVNLPLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YPYEYEGGHIKTAVNLPLER 20 1 B4DIG0;P30305-3;P30305-2;P30305;P30305-4;G8JLH2 B4DIG0 CDC25B M-phase inducer phosphatase 2 1 11015900.0 1626400.0 3008200.0 6381300.0 True False 2227724.0318073793 2875287.777212873 4874168.366998861 1.0 1.2906840058102338 2.1879587854714613 21.087139093473223 -6.950808124111137 0.5499027662920033 0.987583796948627 2.533204425476774 0.9992631679707606 0.013724820216152359 0.08316291013335804 0.03463226156130393 0.01489845180128288 0.0744351340642976 1.1199325722182108e-07 6.950808124111137 1.5456206285281469 up YPYEYEGGHIK(ub)TAVNLPLER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YPYEYEGGHIKTAVNLPLER 20 1 B4DIG0;P30305-3;P30305-2;P30305;P30305-4;G8JLH2 B4DIG0 CDC25B M-phase inducer phosphatase 2 1 20958500.0 6418500.0 6229300.0 8310700.0 True False 5337267.137761972 6195741.524480765 10048428.945664784 1.0 1.1608453098862068 1.8826917758286128 22.347669791382913 -6.942242318267347 0.6383699880750572 0.9921059755140923 2.090896119275578 0.9984430119710159 0.015146278410488585 0.08675855195923668 0.05006338945678963 0.015007420686085252 0.061540345296207506 1.1422408340542299e-07 6.942242318267347 1.098790143761486 YPYEYEGGHIK(ub)TAVNLPLER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YPYEYEGGHIKTAVNLPLER 20 1 B4DIG0;P30305-3;P30305-2;P30305;P30305-4;G8JLH2 B4DIG0 CDC25B M-phase inducer phosphatase 2 1 73307000.0 14811000.0 26398000.0 32098000.0 True False 19173131.468457464 24928928.094293047 26256493.353292335 1.0 1.3002011765946888 1.369442096429997 24.192582649890586 -12.740540862085435 0.22465181508880333 4.690812932235662e-11 1.4067897877080253 0.9994292271253553 0.0038308394539894822 7.423963713493454 0.14252335635152946 3.3611446783886945 0.037144582393114675 1.8174360483484816e-13 12.740540862085435 1.4067897876611173 YPYLWLCYNGEIYNHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YPYLWLCYNGEIYNHK 16 0 P08243-2;P08243;F8WEJ5;C9J057;C9JT45;C9JM09;C9JLN6 P08243-2 ASNS Asparagine synthetase [glutamine-hydrolyzing] 0 35383800.0 8664800.0 12589000.0 14130000.0 False True 13145135.081731487 10342394.591694048 11337199.306600979 1.0 0.7867849609295715 0.862463507305977 23.648025631632905 -10.705395225569733 9.441218625790485 1.0002900958354837 0.8246242352276237 0.8774557582788207 0.030895637182957722 0.00018895976768047663 5.896313713095881e-06 0.029962866766739666 0.009971524023338505 1.970628568038174e-11 10.705395225569733 -0.17566586060785994 YQAAVQALR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQAAVQALR 9 0 P34896-2;P34896;P34896-3;P34896-4 P34896-2 SHMT1 Serine hydroxymethyltransferase, cytosolic 0 4913400.0 1230100.0 1559100.0 2124200.0 False True 1612673.0123053459 1326488.3573242014 1904408.1607652053 1.0 0.8225401846515443 1.1809016125611345 20.62102251473159 -6.772103197497872 1.566848285431208 0.8984852268498845 1.1830577347100784 0.7383754755442462 0.07483272063290151 0.2630464734676573 1.2748299053413217 0.03764250453546057 0.08941671926150228 1.6900392950649783e-07 6.772103197497872 0.28457250786019384 YQAVTATLEEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQAVTATLEEK 11 0 P40429;M0QYS1;Q8J015;Q6NVV1 P40429 RPL13A;RPL13a;RPL13AP3 60S ribosomal protein L13a;Putative 60S ribosomal protein L13a protein RPL13AP3 0 107881000.0 33070000.0 35252000.0 39559000.0 False True 43355090.250335604 29992539.01121978 35465814.15672287 1.0 0.6917881807658701 0.8180311458686985 25.36969805207144 -10.056891345953026 4.9415180204003 1.0000053571989276 0.7549096635630883 0.8340378587281873 0.051538474693175164 3.0418724060252095e-06 5.805747432998123e-07 0.04990300422411133 0.016633971180320842 8.772202612088808e-11 10.056891345953026 -0.24509569363583927 YQAVTATLEEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQAVTATLEEK 11 0 P40429;M0QYS1;Q8J015;Q6NVV1 P40429 RPL13A;RPL13a;RPL13AP3 60S ribosomal protein L13a;Putative 60S ribosomal protein L13a protein RPL13AP3 0 83618000.0 28673000.0 6696000.0 48249000.0 False True 27762791.309806652 9369747.71917871 35611139.46102655 1.0 0.3374929996995307 1.2826930499761249 24.726649289994004 -6.7183133707118055 1.7656164832300154 0.5962146813518734 1.2810606987003306 0.5044839458100913 0.2788437693852459 0.35858279926504916 2.183762744424898 0.12545024684357545 0.3155258678575236 1.912875167502195e-07 6.7183133707118055 0.6848460173484572 YQAVTATLEEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQAVTATLEEK 11 0 P40429;M0QYS1;Q8J015;Q6NVV1 P40429 RPL13A;RPL13a;RPL13AP3 60S ribosomal protein L13a;Putative 60S ribosomal protein L13a protein RPL13AP3 0 113719000.0 33070000.0 40898000.0 39751000.0 False True 45296872.68314686 39090991.1283998 30362632.497543104 1.0 0.8629953639811426 0.6703030628611104 25.43290811359433 -6.9663052208320755 0.33489797203387056 1.022174920021803 0.5047689792303333 0.9999375736880988 0.001068493871521104 0.07752081490627818 0.013313421150073654 0.002764709592924631 0.01674234216931467 1.0806741898385933e-07 6.9663052208320755 -0.5174059407914698 YQAVTATLEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YQAVTATLEEK 11 0 P40429;M0QYS1;Q8J015;Q6NVV1 P40429 RPL13A;RPL13a;RPL13AP3 60S ribosomal protein L13a;Putative 60S ribosomal protein L13a protein RPL13AP3 0 54273000.0 28673000.0 15386000.0 10214000.0 False True 23842869.929274574 15303112.564118098 12349700.17579988 1.0 0.6418318184644687 0.5179619824472876 24.50705456542828 -13.999999999999998 0.14811154007677554 2.7270543651426027 0.37867663308558774 0.9995726648083243 0.004225227937386186 11.951162557227178 0.12110468334265441 5.94376544684423 0.1253218764259743 1.0000000000000041e-14 13.999999999999998 -2.348377732057015 YQAVTATLEEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YQAVTATLEEK 11 0 P40429;M0QYS1;Q8J015;Q6NVV1 P40429 RPL13A;RPL13a;RPL13AP3 60S ribosomal protein L13a;Putative 60S ribosomal protein L13a protein RPL13AP3 0 51261000.0 11894000.0 26769000.0 12598000.0 False True 15397017.46579119 25279281.618157852 10305293.266395932 1.0 1.6418297682861565 0.6693045123376682 23.876147579804538 -6.728738370985011 1.7280365703287617 1.3867946767106807 0.670035973749772 0.5533334915895853 0.2698372037195424 0.33859894795117607 1.9802826966072677 0.12377997228594642 0.30756710727653414 1.8675043797527138e-07 6.728738370985011 -0.7167587029609087 YQAVTATLEEK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQAVTATLEEKR 12 1 P40429;M0QYS1;Q8J015;Q6NVV1 P40429 RPL13A;RPL13a;RPL13AP3 60S ribosomal protein L13a;Putative 60S ribosomal protein L13a protein RPL13AP3 1 21241800.0 6287900.0 9538700.0 5415200.0 True False 8243497.792110209 8115563.141561374 4854887.050266336 1.0 0.9844805380221876 0.5889353248705801 22.9748251854457 -6.915174522067235 0.8597430417254368 1.010335144275855 0.531727146256008 0.9927323404697993 0.01621681539572655 0.10109507975896374 0.12093893075472774 0.01362644815634514 0.039111363438926905 1.2156973721633094e-07 6.915174522067235 -0.478607998019847 YQAVTATLEEK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQAVTATLEEKR 12 1 P40429;M0QYS1;Q8J015;Q6NVV1 P40429 RPL13A;RPL13a;RPL13AP3 60S ribosomal protein L13a;Putative 60S ribosomal protein L13a protein RPL13AP3 1 19018400.0 6287900.0 5027300.0 7703200.0 True False 8612706.554108208 4805177.26294205 5883862.812383945 1.0 0.5579172160056944 0.683160720200943 23.03803524696859 -10.434855858899075 8.958738015194273 1.0000032823801872 0.620538968103323 0.9244682860182896 0.05113044647941388 3.35210461091283e-06 2.1146623159876133e-07 0.049507269570829716 0.016502280641576633 3.674042206783282e-11 10.434855858899075 -0.3794643142768642 YQAVTATLEEKRK(ub) ddPTM_RPMI8226_Bortezomib_8h_R1 1 YQAVTATLEEKRK 13 2 P40429;M0QYS1;Q8J015;Q6NVV1 P40429 RPL13A;RPL13a;RPL13AP3 60S ribosomal protein L13a;Putative 60S ribosomal protein L13a protein RPL13AP3 1 32834900.0 6255200.0 8405700.0 18174000.0 True False 9489595.716375101 6905637.160966142 14581900.934052844 1.0 0.7277061496992838 1.5366198276382352 23.177915194989442 -6.815910711776847 1.3894581571992468 0.8526011183311558 1.552779619584347 0.8747217093028969 0.11894846319677435 0.19884920270407336 0.7554080349014045 0.06729084010667769 0.15529007308192105 1.5278801485306613e-07 6.815910711776847 0.7001785012531913 YQAVTATLEEKRK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YQAVTATLEEKRK 13 2 P40429;M0QYS1;Q8J015;Q6NVV1 P40429 RPL13A;RPL13a;RPL13AP3 60S ribosomal protein L13a;Putative 60S ribosomal protein L13a protein RPL13AP3 1 28655200.0 6255200.0 10184000.0 12216000.0 True False 8097479.708425852 9617251.447544517 9992813.346744934 1.0 1.1876845381331753 1.2340646357343616 22.94904151708189 -13.927426268607634 0.19700845627192537 1.9757868813212465e-09 1.2652099691052967 0.9994834012990813 0.0023000219876365153 12.11465510674529 0.14036255544872656 4.664491522260556 0.030230819593025905 1.1818809467566292e-14 13.927426268607634 1.2652099671295098 YQDIIHSIHLAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQDIIHSIHLAR 12 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 0 5976000.0 1772400.0 1745500.0 2458100.0 False True 2323633.5639460133 1485078.203905711 2203759.39176017 1.0 0.6391189329283655 0.9484108966035626 21.14795114359154 -10.118032215216088 7.2122498576995895 1.000000089823613 0.793764914765964 0.37218467007121614 0.12626791542461047 1.8230480580967614e-07 2.235484428613704e-08 0.12225843714256532 0.04075279446665358 7.62022482414606e-11 10.118032215216088 -0.206235175057649 YQDIIHSIHLAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQDIIHSIHLAR 12 0 Q9UIG0-2;Q9UIG0 Q9UIG0-2 BAZ1B Tyrosine-protein kinase BAZ1B 0 6605200.0 1772400.0 2596500.0 2236300.0 False True 2427704.177309021 2481778.0445227143 1708131.998044218 1.0 1.0222736640316825 0.7035997276808207 21.211161205114433 -6.890135949852009 1.0216028279565648 1.0170670282887841 0.6761202216857503 0.9809842726121792 0.020030893813772686 0.11903193424228427 0.22121613993029093 0.014937395368960134 0.03725656844269571 1.2878463461864877e-07 6.890135949852009 -0.3409468066030339 YQDILVFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQDILVFR 8 0 P19623;K7EKM4 P19623 SRM Spermidine synthase 0 22370100.0 5991000.0 6688700.0 9690400.0 False True 7854259.016926534 5690772.032348392 8687730.364880502 1.0 0.724546010016265 1.1061171201710784 22.90504374515809 -6.713022519183371 1.784216122597989 0.831178942395305 1.1053093529996976 0.479441892261681 0.11602234583386276 0.36908501587993375 2.292141692763114 0.0517093903120861 0.1308974824165625 1.9363215585475696e-07 6.713022519183371 0.2741304106043926 YQDILVFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQDILVFR 8 0 P19623;K7EKM4 P19623 SRM Spermidine synthase 0 15174400.0 5408800.0 2525200.0 7240400.0 False True 5237100.604627437 3533525.5287440345 5343922.032655933 1.0 0.6747102634656007 1.020397054800534 22.32033688852866 -11.040619787744419 12.702268958683229 1.5001271985407343 0.8475536591330673 0.20590979758280759 0.1411260415984247 0.04107968923338763 0.00013136632072588688 0.0028083436651724462 0.04554823406890617 9.107102241834691e-12 11.040619787744419 -0.6525735394076669 YQDILVFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQDILVFR 8 0 P19623;K7EKM4 P19623 SRM Spermidine synthase 0 28821000.0 5991000.0 10314000.0 12516000.0 False True 8206034.60068741 9858293.376163024 9559978.57511132 1.0 1.2013467960928665 1.1649936955311513 22.96825380668098 -10.086672812637763 4.448031842832746 0.9999844936202946 1.1831702458191689 0.9713060405422669 0.014841091197902466 2.33462852600223e-06 4.793622031617034e-07 0.014371068756091848 0.004789941581726248 8.190816328000918e-11 10.086672812637763 0.18318575219887423 YQDILVFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YQDILVFR 8 0 P19623;K7EKM4 P19623 SRM Spermidine synthase 0 11625600.0 5408800.0 2960000.0 3256800.0 False True 4497656.850467706 2944053.8924860028 3937781.822258184 1.0 0.6545750354831659 0.8755185095654193 22.100742163962938 -10.235406779894827 4.837873952136559 1.0000469867397475 0.7650467725238673 0.6012416171122691 0.090199795584697 4.572190223095709e-05 7.226015222126673e-06 0.08735301772454486 0.029111858844027817 5.815582487762209e-11 10.235406779894827 -0.23500021421588013 YQEALHLGSQLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQEALHLGSQLLR 13 0 O00231;O00231-2 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 23183800.0 4878100.0 8474300.0 9831400.0 False True 6395236.339587604 7209967.472562677 8814141.037448015 1.0 1.1273965635846401 1.3782353879382032 22.60856624503009 -6.9603497089893684 0.4304783398894711 0.990086700808669 1.5251720843676344 0.9997829453683904 0.0023149717012242413 0.07957644770737468 0.020671606754456617 0.0032723864140550246 0.020825076114988936 1.0955956292299338e-07 6.9603497089893684 0.5350853835589654 YQEALHLGSQLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQEALHLGSQLLR 13 0 O00231;O00231-2 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 19246100.0 6139500.0 2049600.0 11057000.0 False True 5944604.933092387 2868015.968522801 8160839.997110196 1.0 0.4824569505968595 1.3728145249283912 22.50314950376823 -6.74911385818502 1.652992922752682 0.695355404532576 1.3744783179502014 0.6451861535305434 0.21746696183414196 0.30160197665889243 1.621105817555949 0.10393566584939627 0.2525759068781151 1.7819115457350233e-07 6.74911385818502 0.6791229134176253 YQEALHLGSQLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQEALHLGSQLLR 13 0 O00231;O00231-2 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 22683800.0 4878100.0 7911500.0 9894200.0 False True 6681665.395695754 7561943.770168094 7557393.737445381 1.0 1.1317453542404867 1.1310643813911663 22.67177630655298 -10.131355692717701 4.235661215031173 0.9999725074826399 1.1314048678308022 0.9999798499270592 0.0002780060519600395 194116.9968887743 0.002777887315203432 52.06302504251722 9.516885870470547e-05 7.389997768975965e-11 10.131355692717701 0.1314323603481623 YQEALHLGSQLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YQEALHLGSQLLR 13 0 O00231;O00231-2 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 12321500.0 6139500.0 3383500.0 2798500.0 False True 5105266.275966286 3365272.4139278345 3383653.4111979655 1.0 0.6591766681730781 0.6627770675012506 22.283554779202507 -9.972857098562224 4.876768426752003 1.0000031745366988 0.6609768678287161 0.9999154187828765 0.0014698569062135214 1527381.0833103843 0.1794498219546764 56.9361241634915 0.0005379125424911187 1.0644932243511445e-10 9.972857098562224 -0.3390263067079827 YQEESK(ub)TLSLVSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YQEESKTLSLVSR 13 1 Q10570;A0A087X101;A0A087WTV4 Q10570 CPSF1 Cleavage and polyadenylation specificity factor subunit 1 1 9308400.0 4486300.0 4822100.0 0.0 True False 6806045.092462838 3961558.579760734 0.0 1.0 0.5820646977710815 0.0 22.69838527902513 -7.697034782164685 0.6480277728187118 1.000127875754245 4.8533873819270975e-19 0.9874684421358523 0.04590585405127667 0.1201880018220251 0.15097895708204004 0.042780523564014586 0.07783644571278796 2.008931913030831e-08 7.697034782164685 -1.000127875754245 down YQENAQLSVK(ub)QVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YQENAQLSVKQVR 13 1 Q5VY60;Q7Z4H7-2;Q7Z4H7-3;Q7Z4H7 Q5VY60 HAUS6 HAUS augmin-like complex subunit 6 1 10366900.0 1403700.0 4866800.0 4096400.0 True False 2129515.5242159665 3998281.515518043 3286744.744484099 1.0 1.8775545282723913 1.543423706992789 21.02209381652999 -10.098760496229996 5.05074898763956 0.9999806474236009 1.7104891176315922 0.8577252938604456 0.13640833658637996 3.062205958926056e-05 5.463792546447702e-06 0.13208050071146143 0.04402560132246959 7.965985357220617e-11 10.098760496229996 0.7105084702079912 YQETFNVIER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQETFNVIER 10 0 Q13011;M0R248;M0QZW4 Q13011 ECH1 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial 0 8624600.0 1250700.0 4738500.0 2635400.0 False True 1713117.5888966348 4529137.401875943 2012972.7977667258 1.0 2.643798319059358 1.1750348083596633 20.708192751158034 -6.619155827739719 2.119755639580612 2.0913634055125674 1.1806160140008262 0.07990930382454564 0.7070456328595788 0.5877553375036694 5.0172470760854315 0.2741773644892839 0.7840885039051286 2.403500253445007e-07 6.619155827739719 -0.9107473915117412 YQEVTNNLEFAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQEVTNNLEFAK 12 0 Q14444-2;Q14444;G3V153;E9PLA9 Q14444-2 CAPRIN1 Caprin-1 0 20150500.0 4537400.0 8595500.0 7017600.0 False True 5948575.340244109 7313084.9049965795 6291486.069572497 1.0 1.2293842620637425 1.057645857993675 22.504112759481043 -10.583557202803018 5.1518981183101 0.9989733402421274 1.143515060028684 0.48216187286451917 0.07011190986860012 0.0008325676186572981 6.729890944738675e-05 0.06836118156889309 0.022628521607656563 2.6088120824700616e-11 10.583557202803018 0.14454171978655672 YQEVTNNLEFAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQEVTNNLEFAK 12 0 Q14444-2;Q14444;G3V153;E9PLA9 Q14444-2 CAPRIN1 Caprin-1 0 14932500.0 5446400.0 2627300.0 6858800.0 False True 5273507.013208637 3676394.591188505 5062274.520410551 1.0 0.6971441551097175 0.9599445886259355 22.330331278402593 -10.171968731648219 7.1106354943535575 1.0000002219848243 0.8285443723809077 0.362054340796679 0.10728782771615812 3.775540021779861e-07 4.39744362740463e-08 0.10388112716905114 0.03462699749962091 6.73025111029305e-11 10.171968731648219 -0.17145584960391658 YQEVTNNLEFAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQEVTNNLEFAK 12 0 Q14444-2;Q14444;G3V153;E9PLA9 Q14444-2 CAPRIN1 Caprin-1 0 17122100.0 4537400.0 4726700.0 7858000.0 False True 6214999.398624445 4517858.764893328 6002102.240590016 1.0 0.7269282706436395 0.9657446212977029 22.567322821003934 -10.208092886012837 7.047917256520911 1.000000402972177 0.8463364462059622 0.3556771156566205 0.09749636688933981 6.174166372384355e-07 6.925723355447766e-08 0.09440069889106835 0.031466817106511794 6.193086044572006e-11 10.208092886012837 -0.1536639567662148 YQEVTNNLEFAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YQEVTNNLEFAK 12 0 Q14444-2;Q14444;G3V153;E9PLA9 Q14444-2 CAPRIN1 Caprin-1 0 7408400.0 5446400.0 0.0 1962000.0 False True 4528922.916430136 0.0 2372245.1287369668 1.0 0.0 0.5237989633541517 22.11073655383687 -10.50288723422246 6.577883641808966 1.0003964291489817 0.2618994816770768 0.725841686786707 0.21384003133607604 0.0012438275955225719 9.399995309563936e-05 0.20715341836504936 0.06901657334309122 3.141324241621916e-11 10.50288723422246 -0.738496947471905 YQGGFLISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQGGFLISR 9 0 E9PLK3;P55786;P55786-2;H0YDG0 E9PLK3 NPEPPS Puromycin-sensitive aminopeptidase 0 18233700.0 0.0 8296200.0 9937500.0 False True 0.0 7058439.298334315 8909262.827231068 0.0 YQGVNLYIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQGVNLYIK 9 0 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 143929000.0 50192000.0 38388000.0 55349000.0 False True 65802198.06001938 32660660.03525197 49622016.42509811 1.0 0.49634603399511956 0.7541087970927197 25.97163244083656 -10.292169085416287 4.951576839014835 1.0001171894864445 0.6252274155437221 0.7381241680938971 0.10523120738052083 0.0001361800528047779 1.9466841719910995e-05 0.10192135444757873 0.033963226140406984 5.103062819331978e-11 10.292169085416287 -0.3748897739427224 YQGVNLYIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQGVNLYIK 9 0 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 108918000.0 38981000.0 14076000.0 55861000.0 False True 37743569.492120646 19696620.205370292 41229328.3059214 1.0 0.5218536685959754 1.092353713777083 25.169727532435125 -6.684386538382351 1.8861860039813585 0.6986681471390632 1.0902673202593283 0.34431001415331963 0.20245892449539574 0.42888071074165673 2.9536474891180418 0.08600875829252826 0.22558512286357352 2.0682996650303742e-07 6.684386538382351 0.39159917312026504 YQGVNLYIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQGVNLYIK 9 0 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 133614000.0 50192000.0 29736000.0 53686000.0 False True 68749338.7877987 28422165.196197763 41006472.49787682 1.0 0.41341728804004135 0.5964635183539314 26.034842502359453 -10.300313629494028 5.191098624422981 1.000115482593407 0.5049404031969242 0.9070015119059219 0.07472831060173163 9.98994898585887e-05 1.3465062793911927e-05 0.07237211307573833 0.024118458537526834 5.008254276138508e-11 10.300313629494028 -0.49517507939648286 YQGVNLYIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YQGVNLYIK 9 0 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 0 74118000.0 38981000.0 18305000.0 16832000.0 False True 32414428.65110222 18206387.331741996 20351493.37762521 1.0 0.5616754047313096 0.6278529107108966 24.9501328078694 -10.581697484362616 6.416406052233494 1.0008388978045895 0.5947641577211352 0.9803905465918391 0.02701685368332844 0.00032483943908941446 2.1177101603458117e-05 0.026209072161899542 0.008719652031871132 2.6200073860407357e-11 10.581697484362616 -0.40607474008345423 YQGVNLYIK(ub)NLDDTIDDEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQGVNLYIKNLDDTIDDEK 19 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 15961900.0 5772400.0 6004900.0 4184600.0 True False 5589158.321652014 8402687.885139821 3088527.72469091 1.0 1.5033905646559318 0.5525926350531468 22.41419961149739 -6.7628590430269835 1.6016975678961767 1.2913536638270369 0.5486173420747387 0.7025462459645819 0.2118230053782262 0.27813414491714894 1.4069136578614936 0.10431446071104669 0.24998261456536475 1.7263981302108503e-07 6.7628590430269835 -0.7427363217522982 YQGVNLYIK(ub)NLDDTIDDEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YQGVNLYIKNLDDTIDDEK 19 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 14844900.0 5772400.0 4884300.0 4188200.0 True False 4800006.3606788535 4857987.306442356 5063933.255951153 1.0 1.0120793476938856 1.0549846969858958 22.194604886931668 -6.947607534055939 0.5845373972561053 0.999495376726809 1.0697073735653995 0.9989997035825449 0.0007461964234529469 0.08446122186546712 0.040052509232161776 0.0007780333854618394 0.003588649641986339 1.1282165493986479e-07 6.947607534055939 0.07021199683859047 YQGVNLYIK(ub)NLDDTIDDEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YQGVNLYIKNLDDTIDDEK 19 1 B1ANR0;Q13310-2;Q13310;Q13310-3;H0Y5F5;H0YEU6 B1ANR0 PABPC4 Polyadenylate-binding protein;Polyadenylate-binding protein 4 1 32491500.0 6372100.0 7251400.0 18868000.0 True False 8248809.062869334 6847853.215507108 15434217.602028752 1.0 0.8301626529739426 1.8710843570744486 22.975754411941093 -6.865042295670375 1.1599176587435418 0.9062891611477286 1.9265875201604523 0.959484316530244 0.09177929336251142 0.1417016292922448 0.3594353620127964 0.061572386720981025 0.1446542967971305 1.3644502471542667e-07 6.865042295670375 1.0202983590127237 YQGVNLYVK(ub)NLDDGIDDER ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQGVNLYVKNLDDGIDDER 19 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 24253300.0 10097000.0 8620300.0 5536000.0 True False 13237264.7794871 7334184.841666229 4963187.825061753 1.0 0.5540559144085055 0.37494058687659343 23.65810171258533 -13.999999999999998 0.12573086598691952 3.11963265649147 0.10995111122981965 0.9996653488770216 0.004807803845154382 11.94541535810487 0.10982306259472599 6.283544268363142 0.2353545759587739 1.0000000000000041e-14 13.999999999999998 -3.00968154526165 YQGVNLYVK(ub)NLDDGIDDER ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQGVNLYVKNLDDGIDDER 19 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 51861000.0 14439000.0 21516000.0 15906000.0 True False 13980641.848509012 30107451.004457742 11739741.430228353 1.0 2.153509926847071 0.8397140530053959 23.73692726029002 -6.67478218796104 1.9202207505181577 1.7332162563212445 0.8448714537867974 0.3005145860064261 0.4894497257974293 0.45021197358149645 3.2047350048573207 0.20486470530867767 0.5439965463351264 2.114549285438997e-07 6.67478218796104 -0.8883448025344471 YQGVNLYVK(ub)NLDDGIDDER ddPTM_RPMI8226_Bortezomib_8h_R1 1 YQGVNLYVKNLDDGIDDER 19 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 88776000.0 29645000.0 27876000.0 31255000.0 True False 44973632.33980357 22901310.0038179 25077435.550446864 1.0 0.5092163744032139 0.5576030719727362 25.422576073613047 -10.395483101889097 9.134924761576078 1.0000014019074128 0.533409723762178 0.991998838075764 0.019753786563949438 5.640148769263602e-07 3.728392727838988e-08 0.0191265791515666 0.006375507198892677 4.022693077267498e-11 10.395483101889097 -0.46659167814523483 YQGVNLYVK(ub)NLDDGIDDER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQGVNLYVKNLDDGIDDER 19 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 29711700.0 10097000.0 7190700.0 12424000.0 True False 13830133.761165211 6872991.097534947 9489707.080311824 1.0 0.49695767345607267 0.6861616267919812 23.721311774108223 -10.098761674975798 5.1487811751213854 1.0000093508204373 0.5915596501232794 0.8613708472400738 0.0772421905009953 8.291244173623038e-06 1.4513580544111952e-06 0.0747911413443079 0.024929809785870078 7.96596373627114e-11 10.098761674975798 -0.4084497006971579 YQGVNLYVK(ub)NLDDGIDDER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YQGVNLYVKNLDDGIDDER 19 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 44181000.0 14439000.0 18519000.0 11223000.0 True False 12006668.256157225 18419234.471266292 13569677.410711 1.0 1.5340837339967808 1.130178424289539 23.517332535724297 -10.117821445472124 4.705441247841676 0.9999765567217239 1.3321310791345373 0.47411829076684975 0.16489365221194743 20446736.900621355 43965364.85065715 3101.809939469655 0.05644748967220204 7.623923933162342e-11 10.117821445472124 0.3321545224128134 YQGVNLYVK(ub)NLDDGIDDER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YQGVNLYVKNLDDGIDDER 19 1 P11940;E7EQV3;P11940-2;A0A087WTT1;E7ERJ7;H0YAR2;H0YAP2 P11940 PABPC1 Polyadenylate-binding protein 1;Polyadenylate-binding protein 1 78076000.0 29645000.0 22086000.0 26345000.0 True False 38376036.89031268 20856894.68484567 21550480.322527446 1.0 0.5434874566245429 0.5615608611207966 25.193702395705497 -10.248414872867203 8.47350470677919 1.00000019151794 0.5525241588845043 0.9987779998820898 0.007378436488457477 2.6696043102628676e-08 2.3619203390114905e-09 0.007144143497335168 0.0023813801367370832 5.643975594614766e-11 10.248414872867203 -0.4474760326334356 YQGYIGAALVLGGVDVTGPHLYSIYPHGSTDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YQGYIGAALVLGGVDVTGPHLYSIYPHGSTDK 32 0 Q99436;Q5TBG5 Q99436 PSMB7 Proteasome subunit beta type-7;Proteasome subunit beta type 0 98734000.0 31428000.0 31776000.0 35530000.0 False True 47678573.694563955 26105324.532978814 28507479.926647782 1.0 0.5475273799131117 0.5979096629289069 25.506837742407637 -10.820504679957585 10.970805757897633 1.0045867571849638 0.57271852163782 0.9896799072250365 0.0205684809108649 0.002301417362354077 3.765383782014951e-05 0.01986252805074753 0.006638448668713746 1.5118034080786505e-11 10.820504679957585 -0.4318682355471438 YQGYIGAALVLGGVDVTGPHLYSIYPHGSTDK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YQGYIGAALVLGGVDVTGPHLYSIYPHGSTDK 32 0 Q99436;Q5TBG5 Q99436 PSMB7 Proteasome subunit beta type-7;Proteasome subunit beta type 0 64367000.0 31428000.0 18702000.0 14237000.0 False True 40684165.538497165 17661217.25962076 11646012.083956094 1.0 0.43410543207304897 0.28625417112060764 25.277964064500086 -13.99999999999995 0.18842710973459237 4.01723516904107 0.17848910107370466 0.9994903500526713 0.006944076615268718 12.325504187848468 0.1376533744163325 13.647119553582653 0.10296543839610954 1.0000000000001145e-14 13.99999999999995 -3.8387460679673655 YQHLMTINANNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQHLMTINANNR 12 0 Q9H4L7-3;Q9H4L7;Q9H4L7-2 Q9H4L7-3 SMARCAD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 0 6366200.0 1640300.0 1185600.0 3540300.0 False True 2150449.184687798 1008713.1014326027 3173983.716955586 1.0 0.4690708846389447 1.4759631334494354 21.036206609992888 -6.763431536741042 1.5994569936200207 0.6929241546003949 1.4802904791352536 0.7048411675654279 0.223434822680486 0.2771973300043643 1.3983564208615198 0.1101784361751956 0.2638970769109252 1.724123864765854e-07 6.763431536741042 0.7873663245348587 YQHLMTINANNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQHLMTINANNR 12 0 Q9H4L7-3;Q9H4L7;Q9H4L7-2 Q9H4L7-3 SMARCAD1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 0 3979910.0 1640300.0 769510.0 1570100.0 False True 2246763.237440755 735510.5037707195 1199274.7172245348 1.0 0.3273644910660571 0.5337788589556084 21.09941667151578 -10.255913125401834 5.0866588838822775 1.0000934373818087 0.43057167501070337 0.9102896435449769 0.08426831281886692 8.930835084680628e-05 1.3064179927423693e-05 0.08160573108780733 0.02719748101326068 5.547366692500915e-11 10.255913125401834 -0.5695217623711053 YQHTGAVLDCAFYDPTHAWSGGLDHQLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQHTGAVLDCAFYDPTHAWSGGLDHQLK 28 0 O43684-2;O43684;J3QT28;J3QSX4 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 10425000.0 1776400.0 7350400.0 1298200.0 False True 2328877.602682069 6253748.971634798 1163874.7172137238 1.0 2.6853059879285293 0.49975778713030644 21.15120338807271 -6.700700668362245 1.8279866313832358 2.0457158310113726 0.5060501130707771 0.42121771132394703 0.7112859574383678 0.3939861670121242 2.5598964731060736 0.3103417932155081 0.7975414709123203 1.9920458567856748e-07 6.700700668362245 -1.5396657179405955 YQHTGAVLDCAFYDPTHAWSGGLDHQLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQHTGAVLDCAFYDPTHAWSGGLDHQLK 28 0 O43684-2;O43684;J3QT28;J3QSX4 O43684-2 BUB3 Mitotic checkpoint protein BUB3 0 13056000.0 1776400.0 5561500.0 5718100.0 False True 2433183.0854049567 5315774.540578888 4367602.547966122 1.0 2.1846997755592974 1.795015991260361 21.2144134495956 -10.154964564355932 4.7938641932088535 0.9999150146867706 1.9898578834128682 0.8958679883468205 0.15908773879006083 0.00014967502777280908 2.6383350926882268e-05 0.15404958591392767 0.051345346905838835 6.998991009498814e-11 10.154964564355932 0.9899428687260976 YQIELLLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQIELLLR 8 0 O60437;K7EKI8 O60437 PPL Periplakin 0 15064700.0 3910700.0 3951500.0 7202500.0 False True 5126965.571272678 3361951.602826364 6457254.391258548 1.0 0.6557390636020635 1.2594690370927633 22.28967377907012 -6.752008168704338 1.6421887381568057 0.7980664946984916 1.2608733268270602 0.6576870699948781 0.14467778616233473 0.296540104507864 1.5739746946429498 0.06957505404506817 0.16856969926436055 1.7700756644089238e-07 6.752008168704338 0.46280683212856866 YQIELLLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQIELLLR 8 0 O60437;K7EKI8 O60437 PPL Periplakin 0 16238700.0 5825200.0 2664200.0 7749300.0 False True 5640282.21455327 3728028.95361946 5719525.855983188 1.0 0.6609649680294825 1.014049588019807 22.427335919776315 -10.982174970814512 11.763643723672333 1.1002643680864581 0.8375072780245928 0.22020588276535336 0.14414619250013272 0.07376865887517246 0.00011177898101038507 0.027162359264210595 0.04652298358101854 1.0418975797198386e-11 10.982174970814512 -0.2627570900618653 YQIELLLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YQIELLLR 8 0 O60437;K7EKI8 O60437 PPL Periplakin 0 19668500.0 5704300.0 7399700.0 6564500.0 False True 8653840.140190307 6079165.72088001 5267023.697677445 1.0 0.7024818603531915 0.6086342724562529 23.044909039854623 -13.999999999999998 0.16149476409657426 2.469959178462393 0.5178822932205365 0.9995325151765979 0.0036071025033096215 12.019977986222868 0.1270439275009594 5.533972884372144 0.08287021776070583 1.0000000000000041e-14 13.999999999999998 -1.9520768852418566 YQIELLLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQIELLLR 8 0 O60437;K7EKI8 O60437 PPL Periplakin 0 17170300.0 3910700.0 4683300.0 8576300.0 False True 5356591.4726937525 4476376.320397938 6550754.574442889 1.0 0.8356762585343909 1.2229333911007794 22.352883840593012 -6.791432438347094 1.4907212567907338 0.9083289188398292 1.2272088333209783 0.8058823195066863 0.06992105979362603 0.23323207441660596 1.023900187670999 0.0369168399730163 0.08633769226744792 1.6164696750042945e-07 6.791432438347094 0.31887991448114905 YQIELLLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YQIELLLR 8 0 O60437;K7EKI8 O60437 PPL Periplakin 0 11152150.0 5825200.0 954950.0 4372000.0 False True 4843911.900115454 949805.4948072665 5286164.986155968 1.0 0.1960823223858857 1.0913008112368794 22.20774119521059 -6.670074515047343 1.937593528932658 0.4868841026747905 1.0876459697548888 0.2792115190558756 0.3414826655471542 0.4609197802673072 3.336301052970013 0.14189641807411563 0.37900787441345557 2.1375952953413073e-07 6.670074515047343 0.6007618670800983 YQIELLLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YQIELLLR 8 0 O60437;K7EKI8 O60437 PPL Periplakin 0 18181600.0 5704300.0 7549600.0 4927700.0 False True 7384328.798563358 7129458.12336823 4030909.1624717554 1.0 0.9654849232546749 0.5458734669637111 22.816035361947073 -6.923207854032301 0.8005862728690539 1.0082326065387848 0.47295199469414917 0.9950263063350885 0.01455789664230235 0.09632120570960528 0.09610547295683403 0.012761043592929325 0.03948007464243996 1.193416796576857e-07 6.923207854032301 -0.5352806118446356 YQIHIPLPPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQIHIPLPPK 10 0 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 0 11490600.0 2434700.0 3053100.0 6002800.0 False True 3191915.2776683387 2597589.3808905887 5381687.838923545 1.0 0.813802734384636 1.6860371816807156 21.605990928243497 -6.850879127094211 1.2307868569373697 0.9005562890394568 1.7215119626234427 0.9415818606286389 0.09065425969210258 0.15649272351353982 0.4557342954272083 0.05762104798022647 0.13341995569064133 1.4096810864813825e-07 6.850879127094211 0.8209556735839859 YQIHIPLPPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQIHIPLPPK 10 0 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 0 11202900.0 2555600.0 1398900.0 7248400.0 False True 2474473.8768647164 1957488.06516713 5349826.592661082 1.0 0.7910724309796984 2.162005686412654 21.238690381011143 -6.868047413886939 1.144458832109379 0.8831381930767317 2.2393418070653266 0.9626908291969201 0.11648870640953671 0.13873629462967735 0.3408564195699332 0.07908701881108479 0.18662156066250846 1.3550414682879873e-07 6.868047413886939 1.356203613988595 up YQIHIPLPPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQIHIPLPPK 10 0 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 0 10069800.0 2434700.0 2843800.0 4791300.0 False True 3334874.385293544 2718151.5128109776 3659693.6199209685 1.0 0.8150686349080339 1.0974007405076018 21.669200989766388 -6.729994134093732 1.7233354815889772 0.8887081815543929 1.0972300467920735 0.5592104852621438 0.0777406760064286 0.33624475281441285 1.9563814469245446 0.03574908176293967 0.08870667499333318 1.8621122875750427e-07 6.729994134093732 0.20852186523768057 YQIHIPLPPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YQIHIPLPPK 10 0 P35998;P35998-2 P35998 PSMC2 26S protease regulatory subunit 7 0 5777000.0 2555600.0 1627600.0 1593800.0 False True 2125094.632276156 1618831.7957466957 1927056.2111014144 1.0 0.7617692742524083 0.9068095988917794 21.01909565644542 -10.316169189380213 5.336919533914368 1.0000371363091658 0.8342894366810999 0.6350964485887606 0.059212464582376424 2.6169936492327828e-05 3.3531885114528377e-06 0.05734505865937533 0.0191107407679491 4.828706520512162e-11 10.316169189380213 -0.1657476996280659 YQK(ub)STELLIR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQKSTELLIR 10 1 Q71DI3;Q16695;P68431;Q6NXT2;Q5TEC6;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 Q71DI3;Q5TEC6;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;HIST2H3PS2;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 1 194191000.0 45400000.0 58687000.0 90104000.0 True False 59519839.65422539 49931128.36013423 80780902.41859914 1.0 0.838898905813661 1.3572096781155292 25.8268673040586 -6.823198009929185 1.3578816945057115 0.9134362790851318 1.369329791578007 0.8916038541579516 0.07130893366720283 0.18935585984869557 0.6851398182935998 0.04125704277706407 0.09502421613525645 1.5024567877019854e-07 6.823198009929185 0.45589351249287513 YQK(ub)STELLIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQKSTELLIR 10 1 Q71DI3;Q16695;P68431;Q6NXT2;Q5TEC6;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 Q71DI3;Q5TEC6;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;HIST2H3PS2;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 1 280798000.0 99422000.0 76106000.0 105270000.0 True False 96265903.03085135 106495522.687547 77696628.96769376 1.0 1.106264205026127 0.8071043486995962 26.5205215563718 -6.810664986209032 1.4116132875257192 1.0578675930263162 0.8017843201577121 0.8615913909023505 0.046067622432763966 0.20589138322369835 0.8084616656405568 0.025659276816312356 0.059340906571968555 1.5464469052268458e-07 6.810664986209032 -0.2560832728686041 YQK(ub)STELLIR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YQKSTELLIR 10 1 Q71DI3;Q16695;P68431;Q6NXT2;Q5TEC6;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 Q71DI3;Q5TEC6;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;HIST2H3PS2;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 1 252441000.0 73616000.0 93420000.0 85405000.0 True False 111680854.05049692 76748471.1062085 68524664.31565869 1.0 0.6872124300867756 0.613575754754481 26.734806638439128 -13.999999999999998 0.20319074489375316 2.760253083358958 0.5672286089699137 0.9994873436576385 0.0037930862036297166 12.59581934853765 0.14291608576525833 8.823762585830046 0.04579655592523583 1.0000000000000041e-14 13.999999999999998 -2.1930244743890444 YQK(ub)STELLIR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQKSTELLIR 10 1 Q71DI3;Q16695;P68431;Q6NXT2;Q5TEC6;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 Q71DI3;Q5TEC6;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;HIST2H3PS2;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 1 227777000.0 45400000.0 81917000.0 100460000.0 True False 62185606.88886798 78297636.07670614 76733417.03864503 1.0 1.2590957939291643 1.2339417572264828 25.89007736558149 -10.280045877952169 5.2881693140379635 0.9999615770367459 1.2465187755777656 0.9922518380560911 0.010269092482223224 4.6528320205245e-06 6.334533045034425e-07 0.009944553560364668 0.003314335347013447 5.2475202362582096e-11 10.280045877952169 0.24655719854101965 YQK(ub)STELLIR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YQKSTELLIR 10 1 Q71DI3;Q16695;P68431;Q6NXT2;Q5TEC6;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 Q71DI3;Q5TEC6;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;HIST2H3PS2;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 1 301199000.0 99422000.0 137450000.0 64327000.0 True False 82673798.14139922 136709529.5683111 77777478.285557 1.0 1.6536016566517617 0.940775433499887 26.300926831806077 -6.665515952404739 1.9529323310721673 1.4187728000120132 0.9436814892723363 0.2595321844736127 0.2779226274777241 0.47146211659601484 3.462053571435476 0.11473703220783027 0.30838998037064314 2.160150687160661e-07 6.665515952404739 -0.4750913107396769 YQK(ub)STELLIR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YQKSTELLIR 10 1 Q71DI3;Q16695;P68431;Q6NXT2;Q5TEC6;K7EK07;P84243;K7EMV3;A0A590UJJ6;B4DEB1;K7ES00;K7EP01 Q71DI3;Q5TEC6;K7EK07 HIST2H3A;HIST3H3;HIST1H3A;H3F3C;HIST2H3PS2;H3F3B;H3F3A Histone H3.2;Histone H3.1t;Histone H3.1;Histone H3.3C;Histone H3;Histone H3.3 1 216339000.0 73616000.0 100380000.0 42343000.0 True False 95297363.18830359 94793764.75888835 34637008.47586938 1.0 0.9947155051035341 0.3634624014457578 26.505932960531577 -6.9087328724850545 0.9043070290672164 1.020337090788268 0.28405300097410935 0.9904347568416286 0.029226083918950214 0.10526258641184286 0.14335178524657108 0.023778810460657055 0.06507916436193112 1.2338635293842108e-07 6.9087328724850545 -0.7362840898141587 down YQLAVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQLAVTK 7 0 Q8NDV3-2;Q8NDV3-3;Q8NDV3 Q8NDV3-2 SMC1B Structural maintenance of chromosomes protein 1B 0 3758660.0 1331800.0 862060.0 1564800.0 False True 1824202.4505417286 823971.3387487974 1195226.4680676062 1.0 0.45168853846463414 0.6552049459820991 20.798834418445647 -10.12114676496899 5.213015979439377 1.0000117056977 0.5534467422229109 0.8652160541660827 0.0830852254519487 1.1303832867961882e-05 1.9054966858501368e-06 0.0804490318269323 0.026815641207377266 7.565771750093924e-11 10.12114676496899 -0.44656496347478913 YQLDKDGVVLFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQLDKDGVVLFK 12 1 P07237;H7BZ94;I3L398;I3L312;I3L3U6 P07237 P4HB Protein disulfide-isomerase 0 27227300.0 2492300.0 12443000.0 12292000.0 False True 3267429.4354675296 10586552.902434113 11020141.753189865 1.0 3.2400249528018668 3.37272524803983 21.639724648741872 -10.355952100502567 0.5782439281343573 3.5925887377642275e-20 3.3593203097088926 0.9997257764672672 0.018026627788020135 1.696925861497791 0.27810631499651994 2.6810991395817 0.02371355376342081 4.4060345615783853e-11 10.355952100502567 3.3593203097088926 YQLDKDGVVLFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQLDKDGVVLFK 12 1 P07237;H7BZ94;I3L398;I3L312;I3L3U6 P07237 P4HB Protein disulfide-isomerase 0 22329200.0 8174400.0 2466800.0 11688000.0 False True 7914908.146440332 3451806.104192061 8626562.167515963 1.0 0.43611448677954445 1.0899131118022756 22.916141177116327 -6.6785541591234985 1.9072689597360104 0.6427491616106532 1.0873803220533582 0.317357672861989 0.23906615617800356 0.44177501983000533 3.1058449441579947 0.10062983214178556 0.26587327084290047 2.096263347394261e-07 6.6785541591234985 0.444631160442705 YQLDKDGVVLFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQLDKDGVVLFK 12 1 P07237;H7BZ94;I3L398;I3L312;I3L3U6 P07237 P4HB Protein disulfide-isomerase 0 26089300.0 2492300.0 10532000.0 13065000.0 False True 3413770.661875013 10066661.415333433 9979316.08212122 1.0 2.9488393956154986 2.9232532207187236 21.702934710264763 -10.085631554452595 4.62562394600878 0.999886505652871 2.9360463082218433 0.9998690263975251 0.01044551234555836 829400.5155559783 904206.6124092179 790.9247987583918 0.0035757766923297765 8.2104780720157e-11 10.085631554452595 1.9361598025689724 YQLDKDGVVLFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YQLDKDGVVLFK 12 1 P07237;H7BZ94;I3L398;I3L312;I3L3U6 P07237 P4HB Protein disulfide-isomerase 0 11426500.0 8174400.0 1647800.0 1604300.0 False True 6797375.787321249 1638922.9743373075 1939751.7125549016 1.0 0.24111113253357208 0.2853677320846389 22.696546452550603 -9.949779912979059 6.004823022254371 1.0000003638652797 0.26323943230894115 0.9973010742878595 0.018067681109055857 8.800454993200752e-08 1.54112098856761e-08 0.017493965611725223 0.005831319003243702 1.1225872026769077e-10 9.949779912979059 -0.7367609315563386 YQLEK(ub)TQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQLEKTQR 8 1 F8W7U8;P49959-2;P49959;P49959-3 F8W7U8 MRE11A Double-strand break repair protein MRE11A 1 4321600.0 1395500.0 1948700.0 977400.0 True False 1351200.6163580797 2726826.07233625 721389.6186285163 1.0 2.018076397630667 0.5338878697175948 20.36581046067006 -6.722095315768659 1.75187282884071 1.6179947390482177 0.5359388716192409 0.5223591594881102 0.42830313104346035 0.3512546269759755 2.1079275609517345 0.19404335051812002 0.48590716931631295 1.896289691779292e-07 6.722095315768659 -1.0820558674289766 YQLLQLRPAQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQLLQLRPAQR 11 1 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 0 27402300.0 7109600.0 6806700.0 13486000.0 False True 9320754.44946433 5791166.892308784 12090598.086846607 1.0 0.6213195427159446 1.2971694676004968 23.15201530493858 -6.754700193708004 1.6328282184356993 0.7785924145947871 1.2989777929582702 0.6687972563259734 0.1591739190414721 0.2919154589063364 1.5326664994853139 0.07696979135227186 0.18592139390601323 1.759137579455819e-07 6.754700193708004 0.5203853783634831 YQLLQLRPAQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQLLQLRPAQR 11 1 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 0 15500000.0 5846900.0 3278800.0 6374300.0 False True 5661293.359931248 4588041.938716122 4704679.605098993 1.0 0.8104229275926164 0.8310255812562461 22.432700253264958 -10.10483127436687 5.078631808281819 1.000005096699522 0.8207242544240011 0.9901919178508395 0.008410998138691438 4.8540276584927e-07 8.554887032189524e-08 0.008144145447330492 0.0027146379761299614 7.855407619484629e-11 10.10483127436687 -0.17928084227552088 YQLLQLRPAQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQLLQLRPAQR 11 1 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 0 25278300.0 7109600.0 10950000.0 7218700.0 False True 9738211.24971576 10466192.793192277 5513791.73379322 1.0 1.0747551603481353 0.5662016968418258 23.21522536646147 -6.869531975330515 1.1364933934557602 1.0421663033240784 0.5366724218678075 0.9642177426133451 0.04241035933940779 0.13730837492532857 0.33174761350427334 0.028967667206522364 0.06853082275651198 1.3504173984722743e-07 6.869531975330515 -0.5054938814562709 YQLLQLRPAQR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YQLLQLRPAQR 11 1 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 0 13247700.0 5846900.0 4652800.0 2748000.0 False True 4861956.41158845 4627734.442891511 3322594.094683583 1.0 0.951825572080681 0.683386236611294 22.213105528699234 -6.937420018020124 0.683143806733939 1.0031897301858688 0.6161793470719132 0.9978060635111518 0.006524443460088974 0.08896365732827322 0.060118948773033976 0.006233148825582204 0.023378770952283984 1.1549946750614214e-07 6.937420018020124 -0.3870103831139555 YQLLQLRPAQR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YQLLQLRPAQR 11 1 Q9BXJ9;A0A0B4J1W3;Q9BXJ9-4 Q9BXJ9 NAA15 N-alpha-acetyltransferase 15, NatA auxiliary subunit 0 19031900.0 4615200.0 9155300.0 5261400.0 False True 5974467.37919282 8645799.506844487 4303879.186522901 1.0 1.4471247323159002 0.7203787238862415 22.510378672602023 -6.740233870427014 1.685729061820822 1.265962222212918 0.719920639097972 0.6060510331406778 0.1878618231487261 0.3173870822258032 1.7709834820878225 0.08815688378528659 0.2162828421188025 1.8187212015618704e-07 6.740233870427014 -0.5460415831149461 YQLLQLVEPFGVISNHLILNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQLLQLVEPFGVISNHLILNK 21 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6R991;D6RBK5;D6RIA2;D6RE02;D6RBI2 P43243 MATR3 Matrin-3 0 1004327000.0 644430000.0 89397000.0 270500000.0 False True 623972922.393147 125093688.29919618 199647935.1739448 1.0 0.20047935384666954 0.3199624983857112 29.21690818309551 -10.10457693154966 5.38544894771307 1.0000111390076138 0.26022092642362865 0.980810850161022 0.04877878949870982 6.523926138783437e-06 1.0848216282008814e-06 0.0472305697384185 0.015743286614519306 7.860009454765291e-11 10.10457693154966 -0.7397902125839853 YQLLQLVEPFGVISNHLILNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YQLLQLVEPFGVISNHLILNK 21 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6R991;D6RBK5;D6RIA2;D6RE02;D6RBI2 P43243 MATR3 Matrin-3 0 2959170000.0 1205700000.0 734170000.0 1019300000.0 False True 1829135048.477019 603151627.4036077 817834908.2249397 1.0 0.32974690846682203 0.44711565114117097 30.76851444989051 -9.98047744986574 5.9482753165194575 1.0000005272838226 0.38843127980812003 0.9731192303064113 0.04791558855110995 3.350488141864361e-07 5.7530407741514354e-08 0.046394108523439705 0.015464689706787398 1.0459779999995938e-10 9.98047744986574 -0.6115692474757026 YQLLQLVEPFGVISNHLILNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YQLLQLVEPFGVISNHLILNK 21 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6R991;D6RBK5;D6RIA2;D6RE02;D6RBI2 P43243 MATR3 Matrin-3 0 1227530000.0 644430000.0 224410000.0 358690000.0 False True 535872098.08957607 223201058.7881026 433690420.60482293 1.0 0.41651927686444395 0.8093170406725066 28.997313458529785 -10.15088435293928 5.570228406328388 1.0000072116509904 0.6129181587684576 0.5642342312522441 0.16035901557283497 1.436185595730861e-05 2.1894514560125984e-06 0.15526983993089663 0.051755649727293206 7.065056626297438e-11 10.15088435293928 -0.3870890528825328 YQLLQLVEPFGVISNHLILNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YQLLQLVEPFGVISNHLILNK 21 0 P43243;A8MXP9;A0A0R4J2E8;D6REM6;P43243-2;B3KM87;H0Y8T4;D6R991;D6RBK5;D6RIA2;D6RE02;D6RBI2 P43243 MATR3 Matrin-3 0 2530990000.0 1205700000.0 732470000.0 592820000.0 False True 1560802417.9001539 691707400.6071227 484932842.8468671 1.0 0.44317422415177976 0.31069457433265507 30.53964077198296 -13.999999999999998 0.2016964393236447 4.11549139578905 0.22608020732924133 0.9994870811343901 0.006763826799809328 12.56495580595161 0.14239692960324263 15.454379557359315 0.08330145407851385 1.0000000000000041e-14 13.999999999999998 -3.8894111884598086 YQLLVYHADSLFHDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQLLVYHADSLFHDK 15 0 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 0 9218200.0 2277100.0 3663700.0 3277400.0 False True 2985300.151467768 3117090.2409907468 2938286.087040719 1.0 1.0441463447011123 0.9842514782294391 21.509444561204333 -6.709205913166481 1.7978672427144986 1.027161892457203 0.9843944313785494 0.46140090293843483 0.018605328960228405 0.37667685851058674 2.372861656838676 0.00823652886502199 0.020946139806030495 1.9534130593869112e-07 6.709205913166481 -0.04276746107865359 YQLLVYHADSLFHDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQLLVYHADSLFHDK 15 0 Q9UJX3;Q9UJX3-2 Q9UJX3 ANAPC7 Anaphase-promoting complex subunit 7 0 12358300.0 2277100.0 2965300.0 7115900.0 False True 3119005.4063136852 2834283.241064205 5435270.9765607705 1.0 0.9087137955345868 1.7426295464439903 21.572654622727224 -6.87976187229998 1.0810814243921856 0.943592971224115 1.8014700430356851 0.9734947908512469 0.060800760017744836 0.12784332033685195 0.27353765212633696 0.043331345420497845 0.10472712193760123 1.318979749174394e-07 6.87976187229998 0.8578770718115701 YQNIWNINLQLRPSLITGIMK ddPTM_RPMI8226_Bortezomib_8h_R1 2 YQNIWNINLQLRPSLITGIMK 21 1 Q9Y2Q3;Q9Y2Q3-4;Q9Y2Q3-3;Q9Y2Q3-2;E9PFN5;C9JNT3 Q9Y2Q3 GSTK1 Glutathione S-transferase kappa 1 0 809987000.0 227836000.0 239641000.0 342510000.0 False True 345643869.0427218 196875191.22632122 274812748.37253433 1.0 0.5695897102748474 0.7950748530087982 28.364711094753808 -10.118017347019007 4.96554316564047 1.0000132571470557 0.6823322816406845 0.7257539556784167 0.09205392405007841 1.3510707871591665e-05 2.3998416986316513e-06 0.08913454619209907 0.02971027623268617 7.620485709210549e-11 10.118017347019007 -0.3176809755063712 YQNIWNINLQLRPSLITGIMK ddPTM_RPMI8226_Carfilzomib_8h_R1 2 YQNIWNINLQLRPSLITGIMK 21 1 Q9Y2Q3;Q9Y2Q3-4;Q9Y2Q3-3;Q9Y2Q3-2;E9PFN5;C9JNT3 Q9Y2Q3 GSTK1 Glutathione S-transferase kappa 1 0 498648900.0 227836000.0 100043900.0 170769000.0 False True 294938193.31898403 94476369.01934396 139690794.23790815 1.0 0.3203259908667206 0.4736273477027392 28.135837416846257 -10.203696882192412 8.113436612727451 1.0000002087272901 0.3969766692890758 0.9537695127907 0.06258501685409523 2.3632597794344072e-07 2.320478997414405e-08 0.06059770321851014 0.02019922733316846 6.256091872070428e-11 10.203696882192412 -0.6030235394382143 YQNYIMEGVK(ub)ATIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQNYIMEGVKATIK 14 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 23775000.0 8071800.0 10181000.0 5522200.0 True False 10582207.967422392 8662034.485227179 4950815.716682806 1.0 0.8185469905612781 0.46784335858112247 23.335137339991437 -6.960708208732037 0.4253346541060908 1.014639768033595 0.2584046833470616 0.9997955705021677 0.0031581731130754616 0.07944909105588843 0.020203649852486707 0.004554225042033 0.029152201198611477 1.0946916143260871e-07 6.960708208732037 -0.7562350846865333 down YQNYIMEGVK(ub)ATIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQNYIMEGVKATIK 14 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 52483000.0 18569000.0 19037000.0 14877000.0 True False 17979537.259156708 26638573.3766435 10980267.399566652 1.0 1.4816050598341666 0.6107091212247171 24.099852554779652 -6.756568270717258 1.6252036300128436 1.2809285520576847 0.6080348820093977 0.6768903386067002 0.20247777871743824 0.2887132791911477 1.5021035589132186 0.09833446415647294 0.2371382488728846 1.751587064592285e-07 6.756568270717258 -0.672893670048287 YQNYIMEGVK(ub)ATIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YQNYIMEGVKATIK 14 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 32970000.0 10852000.0 12584000.0 9534000.0 True False 16463277.387470022 10338286.880759226 7649600.721099355 1.0 0.6279604380976753 0.4646462876778935 23.97274822961775 -13.999999999999998 0.11183460620092316 2.789708553976836 0.17281272974779827 0.9997337558137712 0.0036554244179441966 12.002142686777244 0.10177410320124126 4.83413266154069 0.2591029933940131 1.0000000000000041e-14 13.999999999999998 -2.616895824229038 YQNYIMEGVK(ub)ATIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQNYIMEGVKATIK 14 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 22563400.0 8071800.0 8841900.0 5649700.0 True False 11056162.592193056 8451235.621746732 4315357.219223905 1.0 0.7643914017431593 0.39031238761548714 23.39834740151433 -6.964295540713556 0.369943093600251 1.0287855102974486 0.112898309362214 0.9998978791918507 0.0025368199639101896 0.07820082835370715 0.015707800851449672 0.004931068360903286 0.031771263551041054 1.0856865541780966e-07 6.964295540713556 -0.9158872009352346 down YQNYIMEGVK(ub)ATIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YQNYIMEGVKATIK 14 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 45792900.0 18569000.0 19068000.0 8155900.0 True False 15440946.246179331 18965276.899298344 9861260.981379112 1.0 1.2282457691989612 0.6386435665378446 23.880257830213928 -6.801752084264792 1.448890721290611 1.1256534998938061 0.6301610275559134 0.8372037624504618 0.09794086492359885 0.21826305870596088 0.9044234956262494 0.05317568463592742 0.12352952547803674 1.5785121015742083e-07 6.801752084264792 -0.49549247233789273 YQNYIMEGVK(ub)ATIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YQNYIMEGVKATIK 14 1 Q9Y508;A0A096LNV3;A0A096LP02;Q9Y508-2 Q9Y508 RNF114 E3 ubiquitin-protein ligase RNF114 1 35166600.0 10852000.0 16879000.0 7435600.0 True False 14048127.924900442 15939668.81216654 6082397.095698807 1.0 1.1346471855451516 0.43296851567800004 23.7438745517102 -6.856982469393533 1.2007735534608226 1.0725541944951036 0.4008793724897674 0.9498715758605785 0.06807449007609064 0.1499516459170858 0.41254965136833077 0.044265471567055834 0.10301043085428845 1.3900087387749204e-07 6.856982469393533 -0.6716748220053361 down YQPFKPLSIGGIIILK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQPFKPLSIGGIIILK 16 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 30436300.0 10787000.0 15934000.0 3715300.0 False True 14141861.461456599 13556709.310245538 3330876.39567412 1.0 0.9586226924365026 0.2355330947592979 23.75346869556535 -6.918670648947483 0.834542386479523 1.0167325421984066 0.12242679279815412 0.9938031306966392 0.027632922519529153 0.09896071565142525 0.10971970141289938 0.023642326704644744 0.06994292290493948 1.205950136610859e-07 6.918670648947483 -0.8943057494002524 down YQPFKPLSIGGIIILK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQPFKPLSIGGIIILK 16 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 127128000.0 48631000.0 35656000.0 42841000.0 False True 47087235.524263576 49893626.7435836 31619656.897548877 1.0 1.059599829721877 0.6715122802496143 25.488832689195355 -6.867710656640977 1.146065861336652 1.0332864220604236 0.6497445243949352 0.9623482347173404 0.033111482764832494 0.13907271286836648 0.3428247313951457 0.022450861778969235 0.052954862061962496 1.3560925914678742e-07 6.867710656640977 -0.3835418976654884 YQPFKPLSIGGIIILK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YQPFKPLSIGGIIILK 16 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 644080000.0 141510000.0 225760000.0 276810000.0 False True 214681015.76676023 185471364.12906903 222098382.16986683 1.0 0.8639392890267206 1.0345506395924882 27.677619378474 -6.694283097389193 1.8508824119529332 0.9150406902658906 1.0339969362561774 0.3905135792996657 0.05749567400162214 0.4076224990562337 2.710535779602443 0.02481851287059175 0.06428986081976536 2.0217008915493002e-07 6.694283097389193 0.11895624599028676 YQPFKPLSIGGIIILK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQPFKPLSIGGIIILK 16 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 42875680.0 10787000.0 10554680.0 21534000.0 False True 14775245.40771408 10088339.337940693 16448112.706651224 1.0 0.6827865838812818 1.113220948469915 23.81667875708824 -6.709265069847159 1.7980518579903446 0.8048363165460519 1.1121783620813885 0.46152766823442737 0.13368739686341855 0.37654383051738427 2.372634124631669 0.059181394031871185 0.15046989124646407 1.9531469966863004e-07 6.709265069847159 0.3073420455353366 YQPFKPLSIGGIIILK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YQPFKPLSIGGIIILK 16 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 144961500.0 48631000.0 42026500.0 54304000.0 False True 40438831.2185873 41800094.90289293 65658715.32667295 1.0 1.0336622905085333 1.623655119302597 25.26923796462963 -6.918635207370484 0.8347697530898842 0.986331732288939 1.715878272633651 0.9937939015227274 0.022561417090919585 0.09898090200155933 0.10981802339249384 0.01929995897666776 0.05708077943285819 1.2060485548971373e-07 6.918635207370484 0.729546540344712 YQPFKPLSIGGIIILK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YQPFKPLSIGGIIILK 16 1 Q99460;A0A087WW66;Q99460-2 Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0 385620000.0 141510000.0 127730000.0 116380000.0 False True 183187484.5791247 120621713.21630615 95200034.159641 1.0 0.6584604482857325 0.519686344175554 27.448745700566448 -13.999999999999998 0.12395668507713142 2.624250699370235 0.30955801532978366 0.9996737687653358 0.0036453763286962604 11.95029456570167 0.10884411804443976 4.758334859918924 0.18655793372943172 1.0000000000000041e-14 13.999999999999998 -2.3146926840404514 YQQFK(ub)DFQR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQQFKDFQR 9 1 O00148;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 1 17762000.0 4330100.0 8138400.0 5293500.0 True False 5676803.032748056 6924182.443234732 4745779.398837505 1.0 1.2197327269047133 0.8359950788252282 22.43664725481448 -6.751415083287135 1.6447270939392982 1.1289851729530147 0.8351546502599416 0.6549995633777597 0.09233998615146663 0.2975783644844802 1.5842569145387222 0.04434378245105972 0.10749021285557567 1.7724945835000836e-07 6.751415083287135 -0.2938305226930731 YQQFK(ub)DFQR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQQFKDFQR 9 1 O00148;Q13838-2;Q13838;Q5STU3;A0A0G2JJZ9;A0A140T9X3;H0Y400 O00148;Q13838-2 DDX39A;DDX39B ATP-dependent RNA helicase DDX39A;Spliceosome RNA helicase DDX39B 1 15218520.0 5410500.0 7216120.0 2591900.0 True False 5238746.6390579725 10097554.34756868 1913003.6346667225 1.0 1.9274752232309549 0.36516437355533526 22.32079026011272 -6.745892539808911 1.6651511775860608 1.5480559445134048 0.3630286189686936 0.6310407719161835 0.38967798470983317 0.3072773674605996 1.6749799906764373 0.18497376203771373 0.45100155911629025 1.7951777639078848e-07 6.745892539808911 -1.1850273255447112 YQQVK(ub)TDTSQESK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YQQVKTDTSQESK 13 1 Q9HAV4 Q9HAV4 XPO5 Exportin-5 1 18207100.0 1945800.0 3072300.0 13189000.0 True False 2951920.857034571 2524024.061010535 10582188.369055936 1.0 0.8550446245859413 3.5848482671336077 21.493222611625484 -6.894365908976717 0.9962152654713176 0.8683039617568116 3.840729605076888 0.9835481851537776 0.16085314303742124 0.1156715788631859 0.2017356465488974 0.12226892927562757 0.3100154817795137 1.275363815378693e-07 6.894365908976717 2.9724256433200766 up YQQVK(ub)TDTSQESK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQQVKTDTSQESK 13 1 Q9HAV4 Q9HAV4 XPO5 Exportin-5 1 5080600.0 1224400.0 1602900.0 2253300.0 True False 1677093.7681658596 1532078.5779185286 1721116.948170205 1.0 0.9135318531378686 1.0262496831363765 20.67753192315548 -6.70180118283782 1.824991703532385 0.9464000473391908 1.0259198753445329 0.4259015861494375 0.03648753620701699 0.39177650601379693 2.5381739156976177 0.015944674772672578 0.040906282625603425 1.9870043467190863e-07 6.70180118283782 0.07951982800534207 YQQVK(ub)TDTSQESK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YQQVKTDTSQESK 13 1 Q9HAV4 Q9HAV4 XPO5 Exportin-5 1 17357600.0 1945800.0 2478800.0 12933000.0 True False 2518876.4574522004 2340852.6009596805 10579326.703786196 1.0 0.9293241016383201 4.200018096356739 21.264348933717933 -6.90196087405596 0.9487725540610349 0.8712357320681795 4.557357872469835 0.9875173016936342 0.17043067487714647 0.10997678570938631 0.1693846502478139 0.13421031203679565 0.35276248516889985 1.25325407653742e-07 6.90196087405596 3.6861221404016553 up YQSNPK(ub)VMNLISK ddPTM_RPMI8226_Bortezomib_1h_R1 2 YQSNPKVMNLISK 13 1 P50502;Q8NFI4 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 120217500.0 35688300.0 51349000.0 33180200.0 True False 46787706.9059888 43687929.35683434 29747031.19095273 1.0 0.9337480343846967 0.6357873287255531 25.47962618727979 -6.942193620351715 0.6388344119760205 1.0032594021532713 0.5499726923435819 0.9984372823392541 0.006261822717387956 0.0867801231071029 0.05015917741426185 0.006201925226722634 0.025407394974284396 1.142368921950425e-07 6.942193620351715 -0.4532867098096893 YQSNPK(ub)VMNLISK ddPTM_RPMI8226_Bortezomib_2h_R1 2 YQSNPKVMNLISK 13 1 P50502;Q8NFI4 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 189155100.0 62434600.0 68822200.0 57898300.0 True False 60452647.79797226 96303263.36303179 42732998.31823148 1.0 1.5930363163722674 0.7068838152638346 25.849302194444352 -6.726325414212066 1.736310738572008 1.3583304526535207 0.7077222005829082 0.5423028660314915 0.2493784667916974 0.3431632638242733 2.0249812927920736 0.11389087210112717 0.2838300483616555 1.8779091835817898e-07 6.726325414212066 -0.6506082520706125 YQSNPK(ub)VMNLISK ddPTM_RPMI8226_Bortezomib_8h_R1 2 YQSNPKVMNLISK 13 1 P50502;Q8NFI4 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 201538400.0 109199000.0 46940300.0 45399100.0 True False 165662866.5162494 38563436.71876209 36425947.98586763 1.0 0.23278262370873268 0.21987998126480995 27.30367501647692 YQSNPK(ub)VMNLISK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 YQSNPKVMNLISK 13 1 P50502;Q8NFI4 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 119279700.0 35688300.0 50163200.0 33428200.0 True False 48883228.95004376 47946823.95648066 25533147.63538958 1.0 0.9808440437819674 0.5223293997514606 25.542836248802683 -6.915680351463402 0.8561428959178108 1.011775656780229 0.4552660294312527 0.9928946099792811 0.018611957617232205 0.10078075362985563 0.11927483335809674 0.015679508851824127 0.04519220425238201 1.2142822551863882e-07 6.915680351463402 -0.5565096273489762 YQSNPK(ub)VMNLISK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 YQSNPKVMNLISK 13 1 P50502;Q8NFI4 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 162142100.0 62434600.0 75056000.0 24651500.0 True False 51917136.22175182 74651658.43055046 29806014.67434214 1.0 1.4379001590475537 0.5741074497451626 25.62970746987863 -6.768860593716769 1.578623230684889 1.251526111432419 0.5694327227364723 0.7262847443588827 0.18450043619807172 0.26825875380491004 1.3191335990836062 0.0921295563211438 0.21955374196664335 1.7027049801779842e-07 6.768860593716769 -0.6820933886959467 YQSNPK(ub)VMNLISK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YQSNPKVMNLISK 13 1 P50502;Q8NFI4 P50502 ST13;ST13P5 Hsc70-interacting protein;Putative protein FAM10A5 1 58829400.0 29192000.0 25020000.0 4617400.0 True False 37789619.46034772 23627615.005652364 3777080.5785248904 1.0 0.6252408821010911 0.09995021470084249 25.171486655012814 -7.544821746681808 0.5221869604803882 1.0115362647628205 2.382071751785422e-23 0.9960878214422748 0.023089552780765785 0.11689272312514513 0.08132907305323604 0.024982253425418318 0.071151193975096 2.852188689409433e-08 7.544821746681808 -1.0115362647628205 down YQVFFFGTHETAFLGPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQVFFFGTHETAFLGPK 17 0 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 0 17047300.0 8444200.0 6364500.0 2238600.0 False True 11070427.973749116 5414941.408626689 2006971.146167493 1.0 0.4891356884726528 0.18129119767786278 23.400207660826986 -8.515221036004444 0.2816976996216123 1.198569073973002 4.3669966463971405e-22 0.9990053312554771 0.010648757494576985 0.17448894527559788 0.0768432921364926 0.1277275327476308 0.10174936279227066 3.0533666938549347e-09 8.515221036004444 -1.198569073973002 YQVFFFGTHETAFLGPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQVFFFGTHETAFLGPK 17 0 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 0 141637000.0 65893000.0 32750000.0 42994000.0 False True 63801262.783004686 45827245.7889938 31732581.60764732 1.0 0.7182811717200245 0.4973660429821494 25.92708164294697 -7.211493773043739 0.1534342025615508 1.262190294306303 1.1668487649115191e-09 0.9999959933763293 0.0004116986369147694 0.093471755446574 0.007171487689452914 0.018065074552911353 0.03820910018193576 6.14477842085295e-08 7.211493773043739 -1.2621902931394542 down YQVFFFGTHETAFLGPK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YQVFFFGTHETAFLGPK 17 0 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 0 845923000.0 218945000.0 293810000.0 333168000.0 False True 332155572.02355546 241377309.95199218 267317198.7672783 1.0 0.7266995657531057 0.8047951661287229 28.307283875422268 -10.034389354392374 6.7803192674955675 1.0000000664562785 0.765747365940914 0.9230562064752208 0.031882395346096305 3.2043737539993785e-08 4.545499322525745e-09 0.03087000529310255 0.010289998851052437 9.238695335360424e-11 10.034389354392374 -0.2342527005153645 YQVFFFGTHETAFLGPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQVFFFGTHETAFLGPK 17 0 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 0 28490400.0 8444200.0 4879200.0 15167000.0 False True 11566248.935924644 4663620.810643262 11584866.97417013 1.0 0.40320944469369896 1.0016096868006756 23.463417722349877 -10.89856703077737 10.669459434653758 1.0246254409963964 0.7024095657471877 0.2479825268798329 0.24429587585333495 0.11346215124362845 0.001078666219512485 0.1875461537016136 0.07884615489392677 1.2630861389080527e-11 10.89856703077737 -0.3222158752492087 YQVFFFGTHETAFLGPK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YQVFFFGTHETAFLGPK 17 0 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 0 144750600.0 65893000.0 33905600.0 44952000.0 False True 54792949.054849245 33722943.80306532 54351255.365435295 1.0 0.6154613756837167 0.9919388589766942 25.707486918381246 -10.81801644171909 10.1051864731068 1.0028440825327458 0.8037001176231602 0.2660518049204367 0.1536962889524956 0.00994731198591069 0.000179140119499781 0.15031512374739275 0.04960526395724153 1.5204899652384583e-11 10.81801644171909 -0.19914396490958564 YQVFFFGTHETAFLGPK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YQVFFFGTHETAFLGPK 17 0 P51858;P51858-2;P51858-3 P51858 HDGF Hepatoma-derived growth factor 0 695273000.0 218945000.0 274614000.0 201714000.0 False True 283428618.55117285 259331489.49489307 165004121.76042148 1.0 0.9149799015376104 0.582171703774614 28.078410197514717 -6.945371420286345 0.6075386630319327 1.003695077157383 0.47619797247850326 0.998786163460673 0.006281649623628001 0.08539930968440242 0.04407682715658797 0.006400118970245962 0.028039191636667547 1.1340405389503955e-07 6.945371420286345 -0.5274971046788797 YQVQTICEK(ub)GLHVGQSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQVQTICEKGLHVGQSK 17 1 Q9UK61-3;Q9UK61-4;Q9UK61 Q9UK61-3 FAM208A Protein FAM208A 1 7485300.0 3184000.0 2877600.0 1423700.0 True False 4174254.833899858 2448273.296796944 1276389.1810947303 1.0 0.5865174490340374 0.30577653542590383 21.993087247536607 -8.216157590619517 0.21556916266195472 1.2505096449656579 2.6921320585637497e-13 0.9997127467257212 0.004832659661605609 0.08749470913350739 0.04567870384686853 0.10166028609534275 0.11100059666523023 6.079143699103132e-09 8.216157590619517 -1.2505096449653887 down YQVQTICEK(ub)GLHVGQSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQVQTICEKGLHVGQSK 17 1 Q9UK61-3;Q9UK61-4;Q9UK61 Q9UK61-3 FAM208A Protein FAM208A 1 8308200.0 3184000.0 3829100.0 1295100.0 True False 4361210.84436466 3659917.7008595923 989224.053421753 1.0 0.839197606231021 0.2268232582013271 22.0562973090595 -6.946004626455252 0.6011140786106691 1.006880967688948 0.027732429367843408 0.9988492310609158 0.01130009311927077 0.0851309669959404 0.04291647761860692 0.011585055092519175 0.05148108774682385 1.1323883000574102e-07 6.946004626455252 -0.9791485383211047 down YQVSWSLDHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQVSWSLDHK 10 0 P51571 P51571 SSR4 Translocon-associated protein subunit delta 0 680699000.0 113678000.0 128411000.0 438610000.0 False True 149032958.8593181 109252579.34215757 393226844.64420867 1.0 0.7330766306887068 2.6385226976228866 27.151056179213676 -6.871448365208674 1.1264799215478516 0.8476488034589392 2.753193946220115 0.9661037277357529 0.15509363456295358 0.13546987384991013 0.32041730865265144 0.10675858327645278 0.2533964405664802 1.3444716061051412e-07 6.871448365208674 1.9055451427611758 up YQVSWSLDHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YQVSWSLDHK 10 0 P51571 P51571 SSR4 Translocon-associated protein subunit delta 0 345122000.0 67567000.0 34485000.0 243070000.0 False True 65422122.569305845 48255040.33689931 179402675.05630633 1.0 0.7375951504138322 2.7422325661515123 25.963275231497335 -6.873958366704866 1.1128950158156012 0.8473598366986052 2.868840827768486 0.968478906115307 0.15794461180989974 0.13311856615482565 0.30574647340736905 0.10985316680048783 0.26203398185745047 1.3367236543545231e-07 6.873958366704866 2.0214809910698808 up YQVSWSLDHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YQVSWSLDHK 10 0 P51571 P51571 SSR4 Translocon-associated protein subunit delta 0 516354000.0 69034000.0 118610000.0 328710000.0 False True 104729625.06142694 97443118.7958401 263740324.4212889 1.0 0.9304255480594618 2.51829722742345 26.642094356894606 -6.896654114216278 0.98219389646545 0.9277858320866379 2.67408571925701 0.9848263925413383 0.09025262112240581 0.11390966114045133 0.1916418333844722 0.06932860210510326 0.17753291844084532 1.2686618658152804e-07 6.896654114216278 1.7462998871703723 up YQVSWSLDHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQVSWSLDHK 10 0 P51571 P51571 SSR4 Translocon-associated protein subunit delta 0 456260000.0 113678000.0 119132000.0 223450000.0 False True 155707828.63243926 113868354.32315803 170675712.09720546 1.0 0.7312949857643533 1.0961280084387992 27.214266240736567 -6.709359809143205 1.7975383358077268 0.834698734415144 1.095253279191361 0.4620559155219569 0.1132420280538089 0.3763541771062115 2.370105107610268 0.05014178457948516 0.12748023059189495 1.9527209733359258e-07 6.709359809143205 0.260554544776217 YQVSWSLDHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YQVSWSLDHK 10 0 P51571 P51571 SSR4 Translocon-associated protein subunit delta 0 161591000.0 67567000.0 26940000.0 67084000.0 False True 56184954.22562325 26794868.872828685 81110954.23862919 1.0 0.4769047023733061 1.4436419030068088 25.74368050693161 -6.759756288283309 1.6134119307199404 0.6960619738150535 1.4471272975648959 0.68994922009305 0.22000755453679352 0.28333425189512024 1.4535841602497335 0.10759357027864191 0.25862402354570896 1.738776298842879e-07 6.759756288283309 0.7510653237498424 YQVSWSLDHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YQVSWSLDHK 10 0 P51571 P51571 SSR4 Translocon-associated protein subunit delta 0 784634000.0 69034000.0 433260000.0 282340000.0 False True 89365873.86358061 409148700.1338512 230957017.0530423 1.0 4.578355052605736 2.5843983510484585 26.413220678987056 -10.17850139492556 6.8901677679622155 0.9999943947060029 3.581376701827088 0.690847811901806 0.814029414669723 7.05741367157898e-05 8.413817533389627e-06 0.7881822999212732 0.2627268638615672 6.629772182276498e-11 10.17850139492556 2.581382307121085 YQVSWSLDHK(ub)SAHAGTYEVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YQVSWSLDHKSAHAGTYEVR 20 1 P51571 P51571 SSR4 Translocon-associated protein subunit delta 1 101989300.0 2378000.0 3449300.0 96162000.0 True False 3117581.028584759 2934677.8852660903 86212078.69103836 1.0 0.941331711464225 27.653516588845402 21.571995626738616 -6.906400947926005 0.919874359841482 0.07588999161207013 30.85274974023124 0.9894916263610698 1.2894203209737787 0.10684681164818773 0.1520245257606949 1.037230586449782 2.7966921780092737 1.2405065224101365e-07 6.906400947926005 30.77685974861917 up YQVSWSLDHK(ub)SAHAGTYEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQVSWSLDHKSAHAGTYEVR 20 1 P51571 P51571 SSR4 Translocon-associated protein subunit delta 1 190077400.0 2378000.0 3322400.0 184377000.0 True False 3257210.86303366 3175605.3822924206 140830949.9635105 1.0 0.9749462088354836 43.23666961872562 21.635205688261507 -6.903735430098987 0.9383056817454234 1.3464298878420843e-13 48.00843830748967 0.9897138905406428 2.01993700369264 0.104496608063142 0.15645140775614702 1.6330637101062013 4.329576837174402 1.2481436451916888e-07 6.903735430098987 48.008438307489534 up YQYGGLNSGRPVTPPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YQYGGLNSGRPVTPPR 16 1 P62140 P62140 PPP1CB Serine/threonine-protein phosphatase PP1-beta catalytic subunit 0 8241200.0 1187600.0 2121800.0 4931800.0 False True 1626687.8136832512 2028051.8601456939 3767010.4136092975 1.0 1.2467369848635237 2.315754985020629 20.633505971615143 -6.943043724009171 0.6306103151657033 0.9883384811751154 2.631828188725245 0.9985360244575837 0.02184950188752473 0.08640507143534515 0.04848920144908164 0.021795861686897566 0.09084677387849956 1.140134994984684e-07 6.943043724009171 1.6434897075501294 up YREWHHFLVVNMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YREWHHFLVVNMK 13 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 11675700.0 4719600.0 4934900.0 2021200.0 False True 6187441.304671411 4198632.156089534 1812065.6127194427 1.0 0.6785732501283914 0.29286186704532685 22.560911503769663 -7.222975977790086 0.3303241529551174 1.056009811225402 5.5017244652858883e-11 0.9998571013427965 0.0034557273280620793 0.09274306548685865 0.019805868679663885 0.009856565036629591 0.04316243803830529 5.98444696025508e-08 7.222975977790086 -1.0560098111703846 down YREWHHFLVVNMK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YREWHHFLVVNMK 13 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 14350600.0 4899800.0 3657800.0 5793000.0 False True 4744258.531014924 5118378.615175011 4275639.513725189 1.0 1.0788574403596114 0.901223971200936 22.177751198780275 -6.786073281134186 1.5124554520752789 1.0443000974698475 0.8995459912810981 0.788195517134527 0.03344451968869331 0.2412609227467301 1.0903780682842419 0.017411174391930132 0.04087529483289946 1.636540354778322e-07 6.786073281134186 -0.1447541061887494 YREWHHFLVVNMK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YREWHHFLVVNMK 13 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 67316000.0 11291000.0 25785000.0 30240000.0 False True 17129272.482668996 21183465.29087547 24263050.745337162 1.0 1.236682136518548 1.4164670898828866 24.02996054254913 -6.974172129149764 0.12277844634808724 0.6898560929211738 1.9679216508874893 0.9999993895875413 0.00013312374157914257 0.07497050390757656 0.0036642268738595963 0.012265309168274565 0.025515111294403873 1.0612748460212588e-07 6.974172129149764 1.2780655579663156 YREWHHFLVVNMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YREWHHFLVVNMK 13 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 27870300.0 4719600.0 15108400.0 8042300.0 False True 6464563.662394301 14440860.931202373 6142874.376367658 1.0 2.2338492874945044 0.950238051193157 22.624121565292555 -6.655195025741997 1.990487489796293 1.797349452995031 0.9556748232413977 0.21523712248295257 0.525956742004708 0.495887165895862 3.771804506164603 0.21389071848915064 0.5825922636461125 2.2121011129560882e-07 6.655195025741997 -0.8416746297536332 YREWHHFLVVNMK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YREWHHFLVVNMK 13 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 8408500.0 4899800.0 2387600.0 1121100.0 False True 4074400.797944401 2374737.524898504 1355516.8266192733 1.0 0.5828433781223968 0.3326910860863646 21.95815647421455 -8.818198268470473 0.17759832681747717 1.4091972637452908 7.059555155793072e-08 0.99975417344513 0.004315708916807071 0.3353737164081272 0.053021382847017365 0.2223542994399704 0.14647927636680302 1.5198535125633512e-09 8.818198268470473 -1.4091971931497391 down YREWHHFLVVNMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YREWHHFLVVNMK 13 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 57860000.0 11291000.0 28070000.0 18499000.0 False True 14616422.078884155 26507879.824486915 15132371.81576902 1.0 1.813568305665033 1.0352993184036632 23.80108686464158 -10.171642299235852 3.949916475833268 0.9997878605374368 1.4244338113572292 0.28395033034960715 0.31772698414321393 49496495.67562004 100925502.50522064 138347.61604211986 0.11627617634324268 6.735311727152253e-11 10.171642299235852 0.4246459508197924 YRPLFDYFLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YRPLFDYFLK 10 1 A0A0A0MSX9;P41252;J3KR24;Q5TCD1 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 58732400.0 16213700.0 29410700.0 13108000.0 False True 21256317.713694133 25022738.202010702 11751709.90081457 1.0 1.1771906375811318 0.5528572756156946 24.341388360972005 -6.830877104877986 1.3239633887463913 1.0946230922817104 0.5357511463127804 0.9076219786938051 0.0798459103023575 0.17973114971946275 0.6158365908371345 0.047347048095645626 0.10895809252655538 1.4761241825998977e-07 6.830877104877986 -0.55887194596893 YRPLFDYFLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YRPLFDYFLK 10 1 A0A0A0MSX9;P41252;J3KR24;Q5TCD1 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 39852400.0 7745600.0 5791200.0 26315600.0 False True 7499720.167727079 8103656.360709045 19422754.908922248 1.0 1.080527830302367 2.589797282370957 22.838405335577484 -6.917933961540242 0.8399050378802375 0.9641550302921479 2.8219807628323066 0.9935875483403706 0.058552592927275715 0.09940280540237796 0.11202516865773281 0.04990470805446611 0.1466598345259913 1.2079975082439275e-07 6.917933961540242 1.8578257325401588 up YRPLFDYFLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YRPLFDYFLK 10 1 A0A0A0MSX9;P41252;J3KR24;Q5TCD1 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 42004700.0 16213700.0 10612000.0 15179000.0 False True 22208343.04876736 10143126.750808803 11594032.82131788 1.0 0.4567259578319501 0.522057534677779 24.404598422494896 -10.321000157821244 5.7100192354181205 1.000067761915004 0.48939174625569437 0.9878708029091712 0.02667150456062982 2.301069887791477e-05 2.7362789339552216e-06 0.02582797987511854 0.008608191081799504 4.775291001250918e-11 10.321000157821244 -0.5106760156593096 YRPLFDYFLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YRPLFDYFLK 10 1 A0A0A0MSX9;P41252;J3KR24;Q5TCD1 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 18644400.0 7745600.0 4524500.0 6374300.0 False True 6440809.588260358 4500125.620457072 7707136.658566792 1.0 0.6986894362875492 1.1966099219288462 22.61881061101176 -6.7428735549736185 1.6760798997316217 0.8213201485666296 1.1970937226779361 0.6177937932742268 0.12659318776760872 0.3126514575997367 1.725616373371282 0.05972388480415426 0.14610275145044013 1.8077003621431344e-07 6.7428735549736185 0.3757735741113065 YRPLFDYFLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YRPLFDYFLK 10 1 A0A0A0MSX9;P41252;J3KR24;Q5TCD1 A0A0A0MSX9 IARS Isoleucine--tRNA ligase, cytoplasmic 0 65224300.0 8156500.0 36215800.0 20852000.0 False True 10558750.038651897 34200358.89375323 17057149.959587883 1.0 3.23905374864995 1.615451629894411 23.33193572052026 -6.56323885211217 2.33265184681341 2.539778843352994 1.6182236155255647 0.0 0.9768218317330323 0.7514061004681037 7.665723956781171 0.3553859294686883 1.0979923717411373 2.73376480416196e-07 6.56323885211217 -0.9215552278274295 YRVPDVLVADPPIAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YRVPDVLVADPPIAR 15 1 Q14697;F5H6X6;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 14600600.0 1553800.0 7278900.0 5767900.0 False True 2037046.8470206028 6192916.492929974 5171093.037603631 1.0 3.040144364862188 2.538524357045054 20.958047728414005 -10.006892868633713 5.08929102742279 0.9999842064809974 2.789334360966464 0.9443384090353127 0.20478551069847858 3.669801469496709e-05 7.160762671769763e-06 0.19828446021493473 0.06609423936690782 9.842538706635862e-11 10.006892868633713 1.7893501544854666 YRVPDVLVADPPIAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YRVPDVLVADPPIAR 15 1 Q14697;F5H6X6;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 12583900.0 4655600.0 2436100.0 5492200.0 False True 4507810.526346601 3408847.434093676 4053628.057531756 1.0 0.7562091206296574 0.8992454394078223 22.103995446315036 -10.223279415833574 5.145406166638332 1.0000173649302295 0.8277272801342732 0.659180080166847 0.05839433261568556 1.1633490117043798e-05 1.7560641542506862e-06 0.056545766669854176 0.01884668981108385 5.980267135919497e-11 10.223279415833574 -0.1722900847959563 YRVPDVLVADPPIAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YRVPDVLVADPPIAR 15 1 Q14697;F5H6X6;Q14697-2 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 14875400.0 1553800.0 8047100.0 5274500.0 False True 2128281.849866146 7691552.513798856 4028771.731737347 1.0 3.6139727049227997 1.8929690783157915 21.021257789936897 -10.390789965353779 6.231262741045868 0.9997196209373773 2.7534708916192776 0.5805572087119587 0.7025967884444204 0.002737140080188407 0.0002675997238076374 0.6803840774511707 0.22676213839533785 4.066399419026231e-11 10.390789965353779 1.7537512706819003 YSAGCIYYYPSFHYTHNPSQAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSAGCIYYYPSFHYTHNPSQAEK 23 0 O95487-2;O95487;O95487-3 O95487-2 SEC24B Protein transport protein Sec24B 0 15692600.0 3715600.0 5508000.0 6469000.0 False True 4871187.581921583 4686227.870015844 5799649.935029721 1.0 0.9620298523111326 1.1906028740412167 22.215842109533394 -6.864227132112137 1.1642719355030682 0.9791203958118783 1.2025950254988382 0.9585700674004738 0.02035624460038427 0.1425059918765729 0.36470414276418395 0.01361196682308749 0.03193958728746619 1.3670137027260762e-07 6.864227132112137 0.22347462968695997 YSAGCIYYYPSFHYTHNPSQAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSAGCIYYYPSFHYTHNPSQAEK 23 0 O95487-2;O95487;O95487-3 O95487-2 SEC24B Protein transport protein Sec24B 0 14735400.0 3715600.0 5691500.0 5328300.0 False True 5089357.73031449 5440030.710726377 4069865.2797831283 1.0 1.0689031895563406 0.7996815109971914 22.279052171056286 -6.838835547772119 1.2880049097637674 1.0366604208862857 0.7910405062478035 0.9223961708104502 0.03181060742095267 0.17016671195314506 0.5489058804040187 0.01937092778511705 0.04460865476186453 1.4493205569795057e-07 6.838835547772119 -0.2456199146384822 YSAHSSHVTNVSFTHNDSHLISTGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSAHSSHVTNVSFTHNDSHLISTGGK 26 0 B5MBZ0;Q9HC35-2;Q9HC35 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 0 7074800.0 1813700.0 1778500.0 3482600.0 False True 2377778.263895787 1513154.7325387015 3122253.959458104 1.0 0.6363733555455783 1.3130971911327665 21.181182754343297 -6.760743059995542 1.609542772329997 0.7889802452868918 1.3156713920133223 0.6940318502815455 0.1529597395634022 0.2816773374172188 1.4383543602854758 0.07497363384328258 0.18005087748917004 1.7348300651608528e-07 6.760743059995542 0.5266911467264305 YSAHSSHVTNVSFTHNDSHLISTGGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSAHSSHVTNVSFTHNDSHLISTGGK 26 0 B5MBZ0;Q9HC35-2;Q9HC35 B5MBZ0 EML4 Echinoderm microtubule-associated protein-like 4 0 5279300.0 1813700.0 1534200.0 1931400.0 False True 2484273.903399559 1466413.9710790478 1475243.0984316047 1.0 0.5902787003769433 0.5938327075822176 21.24439281586619 -10.55148237517325 6.305277042073229 1.0006061400525756 0.5920557039795804 0.9999430782431002 0.001450917365849494 1.2380343969197316e-05 8.806589532519162e-07 0.0014068227557905394 0.00046828156622152157 2.8087793582020744e-11 10.55148237517325 -0.40855043607299524 YSALFLGVAYGATR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSALFLGVAYGATR 14 0 P56385 P56385 ATP5I ATP synthase subunit e, mitochondrial 0 3780760.0 1549300.0 1458000.0 773460.0 False True 2031147.3034425427 1240472.083239488 693429.7787522151 1.0 0.6107248258838942 0.3413980746629935 20.953863440292498 -8.129474465625487 0.19938548051206878 1.2672001288519128 2.5242289149996827e-17 0.9998103544321183 0.003723110559724289 0.08924821139527696 0.03896263369185543 0.0946845500120446 0.11052712507325486 7.422078346177311e-09 8.129474465625487 -1.2672001288519128 down YSALFLGVAYGATR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSALFLGVAYGATR 14 0 P56385 P56385 ATP5I ATP synthase subunit e, mitochondrial 0 81929000.0 23753000.0 23123000.0 35053000.0 False True 36035037.576905236 18996519.98917638 28124759.185724318 1.0 0.5271680360714041 0.7804836924535193 25.10289701398336 -10.054044925996486 5.154929748211098 1.0000046021700857 0.6538258642614162 0.713469193429902 0.10341568366937551 5.46986956255593e-06 1.0038296959772281e-06 0.10013313578466024 0.033377268381821465 8.829885541219622e-11 10.054044925996486 -0.3461787379086695 YSALFLGVAYGATR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSALFLGVAYGATR 14 0 P56385 P56385 ATP5I ATP synthase subunit e, mitochondrial 0 9410300.0 1549300.0 1790000.0 6071000.0 False True 2122118.0782582206 1710911.881261567 4637154.836169763 1.0 0.8062284086782951 2.185154013661586 21.01707350181539 -6.871318673277992 1.1270457932466789 0.8894759936658677 2.2679785076997647 0.9659841871319179 0.11241508550708176 0.13559936745693915 0.32110805874615184 0.07734252751117901 0.18354966244533674 1.3448731611870972e-07 6.871318673277992 1.378502514033897 up YSALFLGVAYGATR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSALFLGVAYGATR 14 0 P56385 P56385 ATP5I ATP synthase subunit e, mitochondrial 0 9784200.0 5150800.0 2409100.0 2224300.0 False True 4283118.419129764 2396121.7001310918 2689390.845998793 1.0 0.5594339137179241 0.6279048540864809 22.030230134559087 -10.637659313022981 6.5821747116976095 1.0016745180752642 0.5936693839022263 0.9791472760750003 0.027953144351916433 0.0006892832691816902 3.7944189817784146e-05 0.027159533388428258 0.009021838545758687 2.3032479165077126e-11 10.637659313022981 -0.40800513417303785 YSALFLGVAYGATR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSALFLGVAYGATR 14 0 P56385 P56385 ATP5I ATP synthase subunit e, mitochondrial 0 75792000.0 23753000.0 27893000.0 24146000.0 False True 30748726.741629228 26340730.030082416 19751675.75888203 1.0 0.8566445775597259 0.6423575169420327 24.87402333607581 -6.965314984691127 0.3526057601804693 1.0200971768094573 0.47164508860415266 0.999919489235103 0.0013186361131358444 0.07785423974457825 0.014484046180721499 0.002922509991847315 0.018387171765044532 1.0831410495540283e-07 6.965314984691127 -0.5484520882053047 YSASK(ub)PLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSASKPLK 8 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 2432660.0 701060.0 559300.0 1172300.0 True False 678805.2340408431 782631.4067109681 865239.4617538473 1.0 1.1529542900723684 1.2746505453459522 19.372638163500735 -6.9737065687506945 0.14437826449782779 0.8468701054329143 1.5839203961730692 0.9999987669839007 0.00012464054076537172 0.07511737209595033 0.0043897827210799085 0.0065740418064853786 0.015544411508633598 1.0624131346368074e-07 6.9737065687506945 0.7370502907401549 YSASK(ub)PLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSASKPLK 8 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 6112000.0 1176400.0 1281800.0 3653800.0 True False 1784684.8063600925 1053052.77525089 2931624.828482568 1.0 0.5900497227847289 1.642656909519887 20.767237871335585 -6.801086073637177 1.451492161845713 0.7741242360914928 1.657577520291482 0.8353194314918603 0.17580088264449317 0.2192081218430238 0.9116613692783796 0.09527806235912917 0.22143488846835163 1.580934679812112e-07 6.801086073637177 0.8834532841999891 YSASK(ub)PLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSASKPLK 8 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 2272640.0 701060.0 672710.0 898870.0 True False 582962.4522239482 669085.9777075193 1086819.5610946978 1.0 1.1477342582785868 1.864304565325916 19.15304343893501 -6.94048585830193 0.6550351613838565 0.9920190999459697 2.0603296032936216 0.9982267625533555 0.015894999065196782 0.08754580428908833 0.05360699848500916 0.015530085320025644 0.06154298061662746 1.1468698657222224e-07 6.94048585830193 1.0683105033476519 YSASK(ub)PLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSASKPLK 8 1 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 4245640.0 1176400.0 868740.0 2200500.0 True False 1522872.9903108065 820393.8553161653 1800031.579036693 1.0 0.5387145615792485 1.1819971793375366 20.538364193428034 -6.714247259915746 1.7801192305512192 0.7176458195376952 1.1806781543595652 0.48518634062994315 0.19426006086829797 0.36662095648939597 2.2671733001570336 0.08675980525412597 0.21927851692502276 1.930868689037917e-07 6.714247259915746 0.46303233482187 YSASKPLK(ub)GAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSASKPLKGAR 11 2 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 17158700.0 5191200.0 8355600.0 3611900.0 True False 6805713.471652303 7108977.049873712 3238175.235791287 1.0 1.0445601448671893 0.4758024635152789 22.69831498278873 -6.887965716772946 1.034368363396129 1.0320671127796184 0.4287948976619672 0.9795629657559795 0.036919447631490715 0.12080810943259368 0.23162681873514124 0.02726649821893712 0.06749490315260288 1.2942980093637709e-07 6.887965716772946 -0.6032722151176512 down YSASKPLK(ub)GAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSASKPLKGAR 11 2 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 24866300.0 8994200.0 9983800.0 5888300.0 True False 8708684.044176165 13970383.404829197 4345977.584786471 1.0 1.6041899480980406 0.4990395291344615 23.05402330119363 -6.7582566855510855 1.6189486564548183 1.3517108938493005 0.4953377186912333 0.6838168512573537 0.25406552976077856 0.28587014029033836 1.47630814948923 0.12384236450585248 0.2981372172123735 1.7447906065032327e-07 6.7582566855510855 -0.8563731751580672 YSASKPLK(ub)GAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSASKPLKGAR 11 2 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 12415800.0 2961000.0 2937000.0 6517800.0 True False 4492053.478096091 2412869.403114265 5229553.973146773 1.0 0.5371417359298523 1.1641789214324456 22.09894367251344 -6.708930801409363 1.7988571779322091 0.7151377234314089 1.1626700928809597 0.46009122866061314 0.19507859204098044 0.3772307399003787 2.3787969646159293 0.0863190238867887 0.21958872402282004 1.9546508765192747e-07 6.708930801409363 0.44753236944955077 YSASKPLK(ub)GAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSASKPLKGAR 11 2 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 15681100.0 5191200.0 6144200.0 4345700.0 True False 7110526.926905092 5872728.927847667 3319335.1625009 1.0 0.8259203555823976 0.4668198568999252 22.76152504431162 -6.959435492772484 0.4433232122518699 1.0124039801441624 0.26625802038869195 0.9997486709385087 0.0035193698651574666 0.07990346886586049 0.021881580156009082 0.004754787521471386 0.029735656880848962 1.0979043536083119e-07 6.959435492772484 -0.7461459597554705 down YSASKPLK(ub)GAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSASKPLKGAR 11 2 P23526;P23526-2 P23526 AHCY Adenosylhomocysteinase 1 9557100.0 2961000.0 1792100.0 4804000.0 True False 3833072.870035961 1692368.05961749 3929721.293202577 1.0 0.441517319654195 1.0252143453682137 21.87006999460589 -10.956713193292087 12.943686172951196 1.0733879842847243 0.7333658325112044 0.2176648181127555 0.2382933128965896 0.1115503301843824 0.00037305063852729504 0.051000171513014725 0.0769088360300904 1.1048079907556413e-11 10.956713193292087 -0.3400221517735199 YSCQFIEMCLMVTADHGPAVSGAHNTIICAR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSCQFIEMCLMVTADHGPAVSGAHNTIICAR 31 0 P53396;P53396-2;P53396-3 P53396 ACLY ATP-citrate synthase 0 32160700.0 7159300.0 9544400.0 15457000.0 False True 10861181.514938636 7841127.2492624335 12401917.174956225 1.0 0.7219405401224191 1.1418570951878888 23.37267771698781 -6.728140921641979 1.729842461538676 0.8323210447776731 1.141531245356676 0.5506935402301576 0.11690775774828549 0.3397374253549864 1.9907433726657597 0.0535738445892435 0.13322902031618886 1.870075232278615e-07 6.728140921641979 0.30921020057900284 YSDK(ub)HNCPYDYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSDKHNCPYDYK 12 1 O76080 O76080 ZFAND5 AN1-type zinc finger protein 5 1 5524000.0 1391700.0 1214700.0 2917600.0 True False 1824532.1772419722 1033471.494863515 2615714.7395954076 1.0 0.566430950220756 1.433635850450944 20.79909516367659 -6.770755086105442 1.5716162690165403 0.7515704259176783 1.4386526851769301 0.7335059456331541 0.1827636657950073 0.26516478663294885 1.2926821573443745 0.09165936549021052 0.21803183080903485 1.6952935664445634e-07 6.770755086105442 0.6870822592592518 YSDK(ub)HNCPYDYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSDKHNCPYDYK 12 1 O76080 O76080 ZFAND5 AN1-type zinc finger protein 5 1 6501100.0 1391700.0 1612500.0 3496900.0 True False 1906249.099278362 1541254.4181755746 2671004.2409161665 1.0 0.8085272899323801 1.4011832146844363 20.86230522519948 -6.819732724218493 1.372992017128047 0.8967691455789036 1.414051650678125 0.8837768371502733 0.08418839815507709 0.19382815116781538 0.7180318027619674 0.04818537807778474 0.11106960674337167 1.514493018904091e-07 6.819732724218493 0.5172825050992215 YSDK(ub)HNCPYDYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSDKHNCPYDYK 12 1 O76080 O76080 ZFAND5 AN1-type zinc finger protein 5 1 32903200.0 2330800.0 21422000.0 9150400.0 True False 3017266.546936783 20229846.868548587 7485121.091032658 1.0 6.704693322201354 2.4807622974615122 21.524810719888293 -6.569151925478504 2.3094901660211353 4.909666297340371 2.4891749943356563 0.0 2.485048686008746 0.7325266617960261 7.333191638194691 0.9097213008975015 2.787034915653987 2.696795870664808e-07 6.569151925478504 -2.4204913030047144 YSDKHNCPYDYK(ub)AEAAAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSDKHNCPYDYKAEAAAK 18 2 O76080 O76080 ZFAND5 AN1-type zinc finger protein 5 1 9833000.0 1035200.0 5548000.0 3249800.0 True False 1570474.0832573697 4557916.05327815 2607475.605562061 1.0 2.9022548680487823 1.6603111336634182 20.58276870444103 -10.05471144445879 4.803792723419699 0.9999631313489904 2.2812830008765848 0.5866298376912888 0.5070214064856284 32647260.848907877 68333260.70681387 7830.455697690141 0.17356692215659106 8.816344572657357e-11 10.05471144445879 1.2813198695275942 YSDLTTLVAFPSSSVYPTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSDLTTLVAFPSSSVYPTK 19 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 5316000.0 1052900.0 2065500.0 2197600.0 False True 1380362.0962981042 1757335.451255939 1970213.4328677214 1.0 1.2730974401345945 1.427316381804092 20.3966153334366 -11.562103111773581 0.08687979337476062 5.98763497524394e-16 1.8941492163940168 0.9999171131333959 0.0016085883103164034 4.6256852789404235 0.060146872605715634 1.213809216699824 0.32828405339536537 2.74092333469363e-12 11.562103111773581 1.8941492163940161 YSDLTTLVAFPSSSVYPTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSDLTTLVAFPSSSVYPTK 19 0 P25205;P25205-2;J3KQ69;A0A499FHX9 P25205 MCM3 DNA replication licensing factor MCM3 0 6765900.0 1052900.0 2101300.0 3611700.0 False True 1442185.5835526236 2008457.617930129 2758690.845296381 1.0 1.392648519604927 1.9128542656075715 20.45982539495949 -6.967238179063514 0.31729873949381215 0.9264615476823297 2.3957537994255884 0.999952127631941 0.0025868779427054814 0.07720942910002486 0.012223526194097336 0.007973456007218547 0.045869336939834304 1.0783551603396367e-07 6.967238179063514 1.4692922517432587 YSDSLVQK(ub)GYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSDSLVQKGYK 11 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 9943000.0 1229600.0 3875400.0 4838000.0 True False 1612017.507463339 3297205.4261908797 4337410.169372977 1.0 2.045390581011333 2.6906718750209477 20.62043598179637 -8.633925895073697 0.17510782107539558 6.498722363531303e-13 3.6060501155202846 0.9997904433229798 0.010084419286717604 0.22590404330789848 0.04829236448420111 0.48940823280382223 0.3748700645682532 2.3231331654852543e-09 8.633925895073697 3.606050115519635 YSDSLVQK(ub)GYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSDSLVQKGYK 11 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 10543400.0 2122800.0 3499000.0 4921600.0 True False 2055412.875961972 4896168.947043944 3632485.315164836 1.0 2.382085372873051 1.7672776879266967 20.970996790128243 -9.848484122071765 5.469661278230103 0.9999994593990442 2.0746815304095456 0.8029163597451796 0.2509941863774057 85181413.79369326 3.475458390688895 579.9737468865612 0.08592198604574781 1.417476533835673e-10 9.848484122071765 1.0746820710105014 YSDSLVQK(ub)GYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSDSLVQKGYK 11 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 48611800.0 6305800.0 7065000.0 35241000.0 True False 9566359.615730593 5804195.550903045 28275600.903320983 1.0 0.6067298098807434 2.9557325920327684 23.18953859502843 -6.863851611161382 1.1660275909157019 0.7840018584961068 3.078193591541896 0.9581577719013578 0.21012983622634088 0.14289190068864693 0.366990530143914 0.1403114225105419 0.32910454793701654 1.368196228192755e-07 6.863851611161382 2.294191733045789 up YSDSLVQK(ub)GYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSDSLVQKGYK 11 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 9095100.0 1229600.0 2996100.0 4869400.0 True False 1684216.3486905757 2863722.395222225 3719348.0084409555 1.0 1.7003292940652652 2.208355245650376 20.68364604331926 -7.39055073895671 0.11992634303054904 1.660338038722546e-14 3.710321027907929 0.9999963954947089 0.0009405008544008701 0.12356904832473448 0.008611881450945312 0.09713797502824721 0.15826219406991646 4.068639968002164e-08 7.39055073895671 3.7103210279079124 YSDSLVQK(ub)GYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSDSLVQKGYK 11 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 14361400.0 2122800.0 7079600.0 5159000.0 True False 1765202.2559852165 7041460.789609423 6237723.047479109 1.0 3.9890390836144474 3.5337157690168675 20.75140206556252 -9.869109199622292 10.22494594861086 0.9999999388057733 3.7613774262921775 0.9800159889146087 0.18588496479280503 0.0 0.0 0.17998234323821993 0.05999411441273996 1.351732638883049e-10 9.869109199622292 2.761377487486404 YSDSLVQK(ub)GYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSDSLVQKGYK 11 1 P52701;A0A494C0M1;P52701-3;P52701-4;A0A087WWJ1;P52701-2 P52701 MSH6 DNA mismatch repair protein Msh6 1 53254000.0 6305800.0 5034200.0 41914000.0 True False 8162982.405900954 4754042.344582542 34286082.07395772 1.0 0.5823903701110372 4.20019061282952 22.96066491712088 -6.878165162503205 1.0900318167407046 0.7469762937830698 4.447678125084476 0.9721727739916054 0.2695786426537327 0.12926542139790295 0.2822413585721414 0.19082083488838625 0.4593590667796725 1.3238379829149324e-07 6.878165162503205 3.700701831301406 up YSDVHNCSYNYK(ub)ADAAEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSDVHNCSYNYKADAAEK 18 1 Q6FIF0-2;Q6FIF0 Q6FIF0-2 ZFAND6 AN1-type zinc finger protein 6 1 16936700.0 9456400.0 6375900.0 1104400.0 True False 12397431.975907868 5424640.573063541 990127.2821528547 1.0 0.4375616324094646 0.07986551441274171 23.563537973588762 -8.34549867367062 0.4015865276531027 1.0843134688388747 4.925806056890429e-20 0.9968942563610378 0.021106344852606068 0.13419609440933647 0.11314573558929403 0.07786693690677264 0.08116111947191271 4.513374037170792e-09 8.34549867367062 -1.0843134688388747 YSDVHNCSYNYK(ub)ADAAEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSDVHNCSYNYKADAAEK 18 1 Q6FIF0-2;Q6FIF0 Q6FIF0-2 ZFAND6 AN1-type zinc finger protein 6 1 12206600.0 1794900.0 5573500.0 4838200.0 True False 1737921.8819785884 7799027.615418525 3570930.2771112043 1.0 4.4875593640258975 2.0547127659419155 20.728931805092742 -6.551865084206451 2.378178538780225 3.413385358887124 2.05730466964355 0.0 1.5257376796068312 0.7877739862262606 8.33943855926901 0.5486753490212848 1.7231344219017215 2.8063052955905604e-07 6.551865084206451 -1.3560806892435737 YSDVHNCSYNYK(ub)ADAAEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSDVHNCSYNYKADAAEK 18 1 Q6FIF0-2;Q6FIF0 Q6FIF0-2 ZFAND6 AN1-type zinc finger protein 6 1 21048600.0 7408400.0 6153100.0 7487100.0 True False 11239084.426587995 5055031.230610271 6007271.403287494 1.0 0.449772511598162 0.534498289653938 23.422021177793347 -10.744390441602151 6.972455494394676 1.0083853592107264 0.49213540062605 0.9795532367634279 0.03458915404949122 0.004501494778142992 0.00016502416417361573 0.03343744566203293 0.011163601466090198 1.801397511234625e-11 10.744390441602151 -0.5162499585846764 YSDVHNCSYNYK(ub)ADAAEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSDVHNCSYNYKADAAEK 18 1 Q6FIF0-2;Q6FIF0 Q6FIF0-2 ZFAND6 AN1-type zinc finger protein 6 1 13511200.0 9456400.0 1814500.0 2240300.0 True False 12952686.629601132 1734329.3902509005 1711187.2804268028 1.0 0.13389727087872177 0.13211060603567598 23.626748035111653 YSDVHNCSYNYK(ub)ADAAEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSDVHNCSYNYKADAAEK 18 1 Q6FIF0-2;Q6FIF0 Q6FIF0-2 ZFAND6 AN1-type zinc finger protein 6 1 14358600.0 1794900.0 6878100.0 5685600.0 True False 1492538.8775522276 6841046.310104045 6874432.672755816 1.0 4.583496224449041 4.605865063984079 20.50933708052702 -10.425302448819185 0.9679781943779769 2.1367250992384558e-11 4.600002435684707 0.9999937635242859 0.004231843282819514 1.8921444057605088 0.5624729998259841 4.960796695098764 0.002975018051214546 3.755757569228742e-11 10.425302448819185 4.60000243566334 YSDVHNCSYNYK(ub)ADAAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSDVHNCSYNYKADAAEK 18 1 Q6FIF0-2;Q6FIF0 Q6FIF0-2 ZFAND6 AN1-type zinc finger protein 6 1 48028500.0 7408400.0 26089200.0 14530900.0 True False 9590319.841396281 24637313.08575008 11886425.29962474 1.0 2.5689772075592283 1.2394190700832937 23.193147499885796 -6.605726553528766 2.169702200752075 2.0512528125370135 1.2440179216028462 0.037226456487148396 0.6771800864843447 0.6245787894759444 5.565376379810297 0.25831367302927305 0.752282589186847 2.47898241739539e-07 6.605726553528766 -0.8072348909341673 YSDYIK(ub)GSNLDAPEPYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSDYIKGSNLDAPEPYR 17 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 40073600.0 9629600.0 15054000.0 15390000.0 True False 9323913.618976543 21065140.70557293 11358897.30989654 1.0 2.2592595305366188 1.2182542410923118 23.15250420806257 -6.599228024738631 2.1938174548979554 1.8472997942449894 1.2216124859558308 0.018308579249248336 0.544397317733882 0.6428526664947984 5.846179437282301 0.2060851257412187 0.6055872964198314 2.516355377610106e-07 6.599228024738631 -0.6256873082891585 YSDYIK(ub)GSNLDAPEPYR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSDYIKGSNLDAPEPYR 17 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 22636000.0 8019500.0 8778100.0 5838400.0 True False 10984525.868838692 8390254.516705116 4459490.165622392 1.0 0.7638249130539989 0.40597930387448383 23.388969263473186 -6.965089454531452 0.3565140017016906 1.0320899191363273 0.12551746185916077 0.9999149767877628 0.0022516917267445323 0.07793062528313639 0.014752997467552688 0.004836591840451716 0.030629515965015185 1.0837036733562286e-07 6.965089454531452 -0.9065724572771665 down YSDYIK(ub)GSNLDAPEPYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSDYIKGSNLDAPEPYR 17 1 P26358;P26358-2;P26358-3 P26358 DNMT1 DNA (cytosine-5)-methyltransferase 1 1 20992600.0 9629600.0 11363000.0 0.0 True False 8007439.063611852 11301785.26362109 0.0 1.0 1.4114107111947578 0.0 22.932909483496847 -6.855264939186404 1.3941753754225683 1.218006331955979 2.89254345615537e-21 0.90236227062694 0.18519237998399302 0.16971968549128347 0.6630781002719788 0.10696231789934517 0.2244924060660085 1.3955167732694188e-07 6.855264939186404 -1.218006331955979 down YSEGYPGK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSEGYPGKR 9 1 P34897;P34897-3;P34897-2;G3V5L0;G3V4W5;G3V540;G3V2W0;G3V2E4;G3V4X0;G3V4T0;G3V3Y8;G3V241 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial 1 5675060.0 605490.0 1542870.0 3526700.0 True False 586269.05137847 2158946.0369607587 2602951.471267846 1.0 3.6825174924115793 4.439858227459959 19.161203374593875 -9.527624789061957 0.37187653157844813 2.7439737727207675e-26 4.583582921334116 0.9983929957990736 0.05916139902666204 0.8754815456849846 0.15298173039004845 1.3401187432806605 0.20709994995605133 2.9673939775826487e-10 9.527624789061957 4.583582921334116 YSEGYPGK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSEGYPGKR 9 1 P34897;P34897-3;P34897-2;G3V5L0;G3V4W5;G3V540;G3V2W0;G3V2E4;G3V4X0;G3V4T0;G3V3Y8;G3V241 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial 1 1610950.0 465940.0 210680.0 934330.0 True False 638210.6095550474 201371.46097440622 713660.4971303731 1.0 0.3155250914973036 1.1182209860596466 19.28367306648435 -6.680846035543358 1.8986728019175259 0.5672586115510543 1.1152011970176774 0.32807956164507224 0.29004249342518157 0.43665428638717146 3.0440779959223345 0.12253795169674382 0.3228604417084389 2.08523000002157e-07 6.680846035543358 0.5479425854666231 YSEGYPGK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSEGYPGKR 9 1 P34897;P34897-3;P34897-2;G3V5L0;G3V4W5;G3V540;G3V2W0;G3V2E4;G3V4X0;G3V4T0;G3V3Y8;G3V241 P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial 1 5461020.0 605490.0 2199960.0 2655570.0 True False 503491.76275508304 2188108.378822129 3210837.4090316147 1.0 4.345867282612339 6.377139898897382 18.94160865002815 -8.393990874317737 0.30368435741111927 1.0586741380111992e-18 7.4715360335251315 0.9987386444938331 0.07873688069551604 0.13460252559971153 0.08071134865713685 0.6828948627263463 0.6343138743609057 4.036538747200965e-09 8.393990874317737 7.4715360335251315 YSEKEDKYEEEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSEKEDKYEEEIK 13 2 P67936;A0A2R8Y5V9;A0A2R8YE05;K7ENT6;P67936-2;A0A2R8YH90;A0A2R8YHD2;A0A5F9UN72;K7EPB9 P67936 TPM4 Tropomyosin alpha-4 chain 0 5424090.0 1237300.0 613090.0 3573700.0 False True 1198022.5887637793 857900.0342221139 2637640.7612980674 1.0 0.7160967099187733 2.201661960330654 20.192223679779964 -6.8572117530854735 1.1997794722274542 0.8469723849125572 2.269850744119338 0.9501589233358749 0.143752028287532 0.14969875654301815 0.41106926245327846 0.09355195948480487 0.21773283795394308 1.3892750839996613e-07 6.8572117530854735 1.4228783592067809 up YSFCTDHTVLVQTR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSFCTDHTVLVQTR 14 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 140838000.0 31973000.0 37582000.0 71283000.0 False True 41916912.62697242 31974912.093488596 63907318.954818934 1.0 0.7628164883716552 1.524618941369653 25.321029123887804 -6.823075984809757 1.358633466514891 0.872541308504265 1.5423550335540666 0.8912768354123709 0.10495310790861867 0.18952317603811902 0.6865755067724214 0.0606922195831853 0.1397759261883776 1.5028789971369843e-07 6.823075984809757 0.6698137250498015 YSFCTDHTVLVQTR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSFCTDHTVLVQTR 14 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 23106300.0 14248000.0 4178300.0 4680000.0 False True 13795705.038960885 5846716.979546651 3454167.603009472 1.0 0.4238070445138363 0.2503799257272063 23.71771585270561 -13.999999999999998 0.16824169708512962 3.8926257988515536 0.0944982360657672 0.9995171440724151 0.007040843177231574 12.07489262605613 0.12985203127493253 11.397447260816708 0.1436888952212669 1.0000000000000041e-14 13.999999999999998 -3.7981275627857864 YSFCTDHTVLVQTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSFCTDHTVLVQTR 14 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 95662000.0 31973000.0 29854000.0 33835000.0 False True 43794282.137836464 28534951.56602396 25843869.85369855 1.0 0.6515679712756596 0.5901197277845207 25.384239185410696 -13.999999999999998 0.24408819092401352 3.352824439637814 0.5639847045630647 0.9995319367789361 0.0039048074867396153 13.771375983530792 0.1563514882145821 15.831326909545115 0.029321393772938024 1.0000000000000041e-14 13.999999999999998 -2.7888397350747494 YSFCTDHTVLVQTR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSFCTDHTVLVQTR 14 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 25650500.0 14248000.0 2949200.0 8453300.0 False True 11847843.293422535 2933312.0742296376 10220845.946356876 1.0 0.2475819439524575 0.8626756527098138 23.498121128139886 -10.43635893099924 8.367712287076964 1.0000085476748652 0.555128798332076 0.4108875338761284 0.251110955075268 4.00433427888988e-05 2.6973328491754434e-06 0.24314180208587033 0.0810457122547293 3.661348504036516e-11 10.43635893099924 -0.4448797493427893 YSFCTDHTVLVQTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSFCTDHTVLVQTR 14 0 P02751-17;P02751-1;P02751-6;P02751-3;P02751-5;P02751;P02751-14;P02751-7;P02751-10;P02751-9;P02751-8;P02751-11;P02751-13;P02751-4;P02751-12;P02751-16;P02751-2 P02751-17 FN1 Fibronectin;Anastellin;Ugl-Y1;Ugl-Y2;Ugl-Y3 0 39825800.0 14453000.0 18764000.0 6608800.0 False True 18709693.411222477 17719766.90511836 5406066.212014394 1.0 0.9470901802425936 0.28894467125643647 24.157282582077624 -6.92288308415499 0.8030646090724166 1.0130689354637625 0.1754443558381782 0.9949447544816359 0.022997076090723063 0.09650522880295395 0.09704413808159375 0.020122990911354825 0.06204352755156137 1.194309579698046e-07 6.92288308415499 -0.8376245796255843 down YSFIQALVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSFIQALVR 9 0 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 0 7528200.0 1508500.0 2639300.0 3380400.0 False True 1977658.1083347807 2245526.7279108237 3030628.635086482 1.0 1.1354473851911606 1.5324330440706555 20.915361608139662 -6.951973171626358 0.5367443272743663 0.9940268744678017 1.692084418176457 0.9993471725151376 0.005772802973441697 0.0827029559917507 0.03275711594856007 0.006378204044253752 0.032859497939023805 1.1169322437067853e-07 6.951973171626358 0.6980575437086552 YSFIQALVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSFIQALVR 9 0 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 0 5338490.0 2485900.0 792790.0 2059800.0 False True 2406986.4652128657 1109355.1813452328 1520276.5873245555 1.0 0.4608896632275517 0.6316099443417964 21.19879659870402 -10.391616699561636 5.240743926120652 1.0002940598553884 0.5462498037846594 0.9040209705470936 0.06969626291245472 0.00023961594640373767 2.781634520048093e-05 0.06752599015521106 0.022494372129394757 4.0586658791420336e-11 10.391616699561636 -0.45404425607072907 YSFIQALVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSFIQALVR 9 0 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 0 6605900.0 1508500.0 1823700.0 3273700.0 False True 2066233.2156796784 1743122.903830572 2500519.4839678695 1.0 0.8436235031954896 1.2101825994242061 20.978571669662553 -6.790804130016653 1.4932408582560137 0.9126911519420758 1.214160729140435 0.8038666131300398 0.06651171501154828 0.234164704689521 1.0314921478889074 0.03505878299347814 0.08202904427918693 1.6188099681478294e-07 6.790804130016653 0.3014695771983592 YSFIQALVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSFIQALVR 9 0 Q92621 Q92621 NUP205 Nuclear pore complex protein Nup205 0 5726600.0 2485900.0 1366200.0 1874500.0 False True 2067135.9940426107 1358840.0094305312 2266449.2832912537 1.0 0.6573539493031153 1.0964200177555103 20.979201874138298 -6.698472101422494 1.8362600170023096 0.7869138595665187 1.0950797220387487 0.4103586858298669 0.1446758344571805 0.3987077928070597 2.612582589528127 0.06288053474845944 0.1620213378977451 2.0022942425346258e-07 6.698472101422494 0.30816586247223 YSFLQFDPAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSFLQFDPAPR 11 0 P67775;P67775-2;H0YBN9;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0 44364000.0 12373000.0 12504000.0 19487000.0 False True 16221122.82030245 10638451.940210246 17470672.17250332 1.0 0.6558394297400362 1.0770322354403807 23.951370350056294 -6.689469412734592 1.8680808948759369 0.7841281653010649 1.0755759373452152 0.3680290449098884 0.14557114464382503 0.4178173589482067 2.826467997497368 0.062345821624486326 0.16247472682399938 2.044233905879485e-07 6.689469412734592 0.2914477720441503 YSFLQFDPAPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSFLQFDPAPR 11 0 P67775;P67775-2;H0YBN9;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0 36785400.0 11317000.0 5073400.0 20395000.0 False True 10957748.02961262 7099235.07743148 15052937.663115 1.0 0.6478735464847565 1.3737254792166593 23.385447998975753 -6.77476009139837 1.5559689494425542 0.7992649457391965 1.378591695750555 0.7485438831793824 0.14861669435485034 0.25878965705314666 1.2370462963164712 0.07525446840285858 0.17838571180187243 1.6797316623958834e-07 6.77476009139837 0.5793267500113586 YSFLQFDPAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSFLQFDPAPR 11 0 P67775;P67775-2;H0YBN9;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0 42322000.0 12373000.0 12968000.0 16981000.0 False True 16947632.467752513 12395030.880558671 12970437.534672827 1.0 0.731372414651049 0.76532445221199 24.014580411579185 -10.173130175302889 7.849246415148717 1.0000000813756547 0.7483484335275439 0.9865319444184155 0.01386086129201903 1.97367375040961e-08 2.063732043418716e-09 0.013420725636647285 0.004473573745673389 6.712276291938876e-11 10.173130175302889 -0.2516516478481108 YSFLQFDPAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSFLQFDPAPR 11 0 P67775;P67775-2;H0YBN9;P62714 P67775;P62714 PPP2CA;PPP2CB Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform;Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform 0 26330300.0 11317000.0 8493200.0 6520100.0 False True 9410586.928106615 8447445.445831796 7883422.76446376 1.0 0.8976534099697647 0.8377184998863704 23.16585327441003 -13.999999999964212 0.05817051024856281 1.66480992921097 0.5550597412750716 0.9999587330026368 0.0004303721584199301 12.48296132624988 0.06095970791847233 1.2286325663905266 0.26593080742932873 1.0000000000824055e-14 13.999999999964212 -1.1097501879358984 YSFMATVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSFMATVTK 9 0 O43865 O43865 AHCYL1 Putative adenosylhomocysteinase 2 0 7401700.0 1981200.0 2098700.0 3321800.0 False True 2597372.385968093 1785582.1406685244 2978092.0009555924 1.0 0.6874571202477007 1.1465787566866728 21.308621437740012 -6.723416015826887 1.7470657370900515 0.8105496938734645 1.1460024413029353 0.5285740213560874 0.13146702829945162 0.34871938797939667 2.0819133229525475 0.0597086064752583 0.14928968630927342 1.890531788210062e-07 6.723416015826887 0.33545274742947073 YSFMATVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSFMATVTK 9 0 O43865 O43865 AHCYL1 Putative adenosylhomocysteinase 2 0 6176600.0 1981200.0 1040600.0 3154800.0 False True 2713703.1799168573 994622.8511959697 2409701.2151455046 1.0 0.3665186592833057 0.8879752336139184 21.371831499262903 -10.185868833578443 7.66995891395799 1.0000002123579927 0.6272469464486476 0.4052257415320413 0.21288375502161494 7.728572593843126e-07 8.209365457530262e-08 0.206123926182715 0.06870793648973454 6.518252297948105e-11 10.185868833578443 -0.3727532659093451 YSGAYGASVSDEELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSGAYGASVSDEELK 15 0 C9JRZ6;Q9NX63;F8WAR4;A0A286YEX5 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 0 9192600.0 2996100.0 3678900.0 2517600.0 False True 3927916.114273673 3130022.4602398807 2257102.9025244713 1.0 0.7968659129113469 0.5746311369334937 21.905332688688173 -6.969972531340185 0.2588482374672638 1.063276530272327 0.3016371001606909 0.9999821644386968 0.0007336111320809423 0.07631168102867435 0.009062364106080807 0.004673944029616207 0.021004613835006052 1.0715870798268229e-07 6.969972531340185 -0.7616394301116362 YSGAYGASVSDEELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSGAYGASVSDEELK 15 0 C9JRZ6;Q9NX63;F8WAR4;A0A286YEX5 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 0 8267600.0 2996100.0 2124600.0 3146900.0 False True 4103839.136558093 2030728.1468873317 2403667.0324398982 1.0 0.4948361958920524 0.5857118060567704 21.968542750211064 -10.052531174316538 5.203313627215161 1.0000054015879867 0.5402740009733491 0.9715283076347827 0.03709981249852821 2.324775677433837e-06 4.2327705861391046e-07 0.03592216089920746 0.011973912995620322 8.86071617812171e-11 10.052531174316538 -0.4597314006146376 YSGAYGASVSDEELK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSGAYGASVSDEELKR 16 1 C9JRZ6;Q9NX63;F8WAR4;A0A286YEX5 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 41646510.0 14675000.0 15731000.0 11240510.0 True False 19239067.112902135 13383996.118957726 10077449.851785565 1.0 0.6956676246522436 0.5238013773041734 24.197535509877735 -11.707409175264273 0.0857894059231862 2.1495960964078673 1.6899417893193095e-07 0.9999190189054317 0.0017718706762256424 4.935560926874335 0.060535493430829125 1.434424841990832 0.37238060501382986 1.961511346752957e-12 11.707409175264273 -2.149595927413688 YSGAYGASVSDEELK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSGAYGASVSDEELKR 16 1 C9JRZ6;Q9NX63;F8WAR4;A0A286YEX5 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 63656100.0 27039500.0 16289500.0 20327100.0 True False 26181145.87317398 22793982.298620302 15002822.710071335 1.0 0.8706258468990744 0.5730391932708987 24.64202490547362 -6.957221462136845 0.4729772616967672 1.0076369281713438 0.4237673430989356 0.999652831172905 0.003330704574143576 0.08070914890955391 0.02491591113860824 0.004137990168222495 0.024556599104114913 1.1035157546375463e-07 6.957221462136845 -0.5838695850724082 YSGAYGASVSDEELK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSGAYGASVSDEELKR 16 1 C9JRZ6;Q9NX63;F8WAR4;A0A286YEX5 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 75409200.0 39127200.0 22318000.0 13964000.0 True False 59358822.981479645 18335178.52867012 11204009.279361388 1.0 0.30888716466616634 0.18875052968717246 25.822959149438148 -13.999999999999998 0.24613610242782683 5.714336344823899 0.13863842788560224 0.9995355782846309 0.007704078653893648 13.848120549929677 0.1569986651036562 32.20440158945979 0.05665921628956422 1.0000000000000041e-14 13.999999999999998 -5.575697916938297 YSGAYGASVSDEELK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSGAYGASVSDEELKR 16 1 C9JRZ6;Q9NX63;F8WAR4;A0A286YEX5 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 38677830.0 14675000.0 14180700.0 9822130.0 True False 20100744.07696337 13554149.784696056 7502345.187117141 1.0 0.674310848036213 0.37323718755840823 24.260745571400626 -7.281051217553023 0.23666326176191893 1.1315393472994022 9.626945599490913e-15 0.9999586169502007 0.0016464471311474205 0.10323894666989888 0.014468111808316883 0.015633682837355275 0.0456078010779722 5.235386905747591e-08 7.281051217553023 -1.1315393472993927 down YSGAYGASVSDEELK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSGAYGASVSDEELKR 16 1 C9JRZ6;Q9NX63;F8WAR4;A0A286YEX5 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 52276900.0 27039500.0 17837000.0 7400400.0 True False 22484542.302954704 17740908.540632706 8947789.42441643 1.0 0.7890268924131654 0.39795292712009517 24.422430180907895 -6.96150316825391 0.4137040474706269 1.0185036566701584 0.15387508043782727 0.9998219496710489 0.0033281912521404503 0.07916846179139433 0.019179074592593565 0.0050421848033967535 0.032613691383335745 1.0926896557984216e-07 6.96150316825391 -0.8646285762323311 down YSGAYGASVSDEELK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSGAYGASVSDEELKR 16 1 C9JRZ6;Q9NX63;F8WAR4;A0A286YEX5 C9JRZ6 CHCHD3 MICOS complex subunit MIC19 1 75308500.0 39127200.0 25559300.0 10622000.0 True False 50650931.71241842 24136902.486569572 8688904.990923764 1.0 0.47653422494993847 0.1715448205426288 25.594085471530597 -8.589241754606142 0.28418695533764055 1.2055147591844584 4.687051548643616e-13 0.9989358241893814 0.011160315115875862 0.20963020564965287 0.0809285119746913 0.1396416139010343 0.10141516694412771 2.574887419734016e-09 8.589241754606142 -1.2055147591839896 YSGK(ub)EGDKFK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSGKEGDKFK 10 2 P26447 P26447 S100A4 Protein S100-A4 1 9947700.0 2141200.0 4669300.0 3137200.0 True False 2807133.935410298 3972658.6407888485 2812592.6381473504 1.0 1.4152009601950803 1.0019445822189652 21.420666469420592 -9.883457520035716 12.538612983349513 1.0000002955922689 1.208572771193712 0.253529054866507 0.16871120983212334 0.0 0.0 0.1633539264995407 0.054451308833180216 1.30780345380141e-10 9.883457520035716 0.2085724756014431 YSGK(ub)EGDKFK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSGKEGDKFK 10 2 P26447 P26447 S100A4 Protein S100-A4 1 13925800.0 3794100.0 5522200.0 4609500.0 True False 3673658.372285341 7727243.257892562 3402133.667964141 1.0 2.103419119259457 0.9260887440243151 21.808786040213896 -6.660769510258276 1.970040425924526 1.709806948225228 0.9309824832124588 0.23890654470088724 0.4697246890488182 0.4826390026263052 3.601630917216529 0.19257537874140013 0.5207967055232785 2.1838886426134113e-07 6.660769510258276 -0.7788244650127693 YSGK(ub)EGDKFK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSGKEGDKFK 10 2 P26447 P26447 S100A4 Protein S100-A4 1 9582500.0 2141200.0 3587200.0 3854100.0 True False 2932859.5037542786 3428705.6427159184 2943840.957681089 1.0 1.1690657661326496 1.0037442822994942 21.483876530943483 -10.847521119548418 2.8293616617117157 0.9680202897692374 1.0864050242017587 0.2669778329244986 0.06749221400979483 50856404.286348306 35946366.733623475 10978393.923218517 0.024699625217324862 1.4206231269065527e-11 10.847521119548418 0.11838473443252129 YSGK(ub)EGDKFK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSGKEGDKFK 10 2 P26447 P26447 S100A4 Protein S100-A4 1 10599600.0 3794100.0 5281800.0 1523700.0 True False 3154962.257129034 5253345.895044779 1842298.6252071953 1.0 1.6651057815903134 0.5839368192263757 21.589191315648172 -6.740282185315063 1.6859305448364381 1.3956046653399568 0.5832947156877583 0.6061378137945135 0.2794454667005021 0.31728421964215847 1.7709199927105728 0.13112801496103305 0.32164347868380266 1.8185188816446592e-07 6.740282185315063 -0.8123099496521985 YSGLCPHVVVLVATVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSGLCPHVVVLVATVR 16 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 21196300.0 6596200.0 8993900.0 5606200.0 False True 8647682.077691669 7652045.177947607 5026124.202467703 1.0 0.8848666161869554 0.5812105668678016 23.04388205431063 -6.954305068553252 0.5093961894547663 1.0056164045627438 0.4471526834932469 0.9994972443089447 0.003960881906884634 0.08180176635973 0.029154435162159983 0.004566929629345154 0.025060458643301912 1.1109510696569006e-07 6.954305068553252 -0.5584637210694969 YSGLCPHVVVLVATVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSGLCPHVVVLVATVR 16 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 256873000.0 62695000.0 88688000.0 105490000.0 False True 95112898.6184513 72860933.47749318 84639855.26209052 1.0 0.7660468194726916 0.889888295820173 26.50313766787376 -10.128808864497401 4.538904011880221 1.00001911425319 0.8279675576419446 0.7201173045044715 0.05055807102266026 70586338.33222653 0.5750692156691415 14100.861860518864 0.01730737247463199 7.433462168677465e-11 10.128808864497401 -0.17205155661124538 YSGLCPHVVVLVATVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSGLCPHVVVLVATVR 16 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 40845200.0 6596200.0 12142000.0 22107000.0 False True 9034993.39560245 11605526.291775392 16885781.907956686 1.0 1.284508552870009 1.8689312950882073 23.10709211583352 -6.959519472882016 0.442161253350632 0.979568202834748 2.196739106005385 0.9997519398162685 0.005696974428803084 0.07987333578143027 0.021769636017002915 0.007726442812209618 0.04840368318812887 1.0976920708884931e-07 6.959519472882016 1.2171709031706368 YSGLCPHVVVLVATVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSGLCPHVVVLVATVR 16 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 220596000.0 62695000.0 92040000.0 65861000.0 False True 81159913.40320988 86917893.09033751 53874973.790927365 1.0 1.0709461043720125 0.6638126081193749 26.274263989966208 -6.861937667932623 1.175810629392609 1.038712427118457 0.643345955614077 0.9559582465895626 0.03726723567809825 0.14482444720026183 0.3793546213711986 0.02469914013400484 0.05779052730226122 1.3742391983875696e-07 6.861937667932623 -0.39536647150437987 YSGSYNDYLR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSGSYNDYLR 10 0 Q96PK6 Q96PK6 RBM14 RNA-binding protein 14 0 3974930.0 1428100.0 984530.0 1562300.0 False True 1382765.7472024164 1377657.9632561242 1153086.7620046374 1.0 0.9963061104481173 0.8338988468130188 20.39912534116031 -6.911800978772125 0.8833662915393494 1.0047465900336434 0.8120802912788696 0.9915839534316457 0.0071047127268405175 0.10323949025943042 0.1323911428884142 0.005869018783708984 0.01641093390661683 1.2251775245486263e-07 6.911800978772125 -0.1926662987547738 YSGTLNLDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSGTLNLDR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 54143000.0 15076000.0 15230000.0 23837000.0 False True 19764781.9961917 12957743.366075037 21370575.900649782 1.0 0.6555975860787004 1.0812452120528062 24.236428706657318 -6.691437184913555 1.860976275049359 0.7843661788894746 1.07980953488387 0.3771342351742796 0.1456173296032755 0.41368604828608263 2.7787586351682805 0.06256599304857463 0.16265162566613425 2.0349925099434714e-07 6.691437184913555 0.29544335599439553 YSGTLNLDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSGTLNLDR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 31580400.0 15076000.0 8254400.0 8250000.0 False True 20650004.613580946 7889693.314349436 6301519.91408344 1.0 0.382067387489134 0.3051582811724459 24.29963876818021 -13.999999999999998 0.2938617506778988 6.442316817473255 0.28500396202664036 0.9996361076640783 0.005932865906587455 16.199443246326023 0.17199610931259543 53.41683712644588 0.028549137220178773 1.0000000000000041e-14 13.999999999999998 -6.157312855446615 YSGTLNLDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSGTLNLDR 9 0 P49327;A0A0U1RQF0 P49327 FASN Fatty acid synthase;[Acyl-carrier-protein] S-acetyltransferase;[Acyl-carrier-protein] S-malonyltransferase;3-oxoacyl-[acyl-carrier-protein] synthase;3-oxoacyl-[acyl-carrier-protein] reductase;3-hydroxyacyl-[acyl-carrier-protein] dehydratase;Enoyl-[acyl-carrier-protein] reductase;Oleoyl-[acyl-carrier-protein] hydrolase 0 9062700.0 4022500.0 3209700.0 1830500.0 False True 3344886.9769646367 3192408.709024431 2213249.0867242673 1.0 0.9544145231243137 0.6616812771152915 21.673526032649075 -6.9344150431508815 0.7096148560992412 1.003806654515921 0.5942181504672694 0.9973370568877412 0.007735399229554622 0.09040930627730467 0.06691844079464868 0.007242537438229852 0.02587453965238035 1.163014037993545e-07 6.9344150431508815 -0.40958850404865155 YSHDFNFHINYGDLGFLGPEDLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSHDFNFHINYGDLGFLGPEDLR 23 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 362712000.0 112540000.0 119226000.0 130946000.0 False True 170731407.7760668 97949188.78301011 105064465.70432934 1.0 0.5737033979798336 0.6153786644934894 27.347153240280804 -10.005027780730261 7.366314008408682 1.0000000189962663 0.594541031756477 0.992138659008849 0.017013856308826146 5.324146361747302e-09 6.998059279684891e-10 0.016473596271137675 0.005491198511570765 9.884898614138896e-11 10.005027780730261 -0.40545898723978935 YSHDFNFHINYGDLGFLGPEDLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSHDFNFHINYGDLGFLGPEDLR 23 0 Q9Y4L1;A0A494C039;A0A087X054;E9PJ21;A0A087WWI4;K7EQK2;Q9Y4L1-2 Q9Y4L1 HYOU1 Hypoxia up-regulated protein 1 0 252200000.0 112540000.0 45945000.0 93715000.0 False True 145685248.49505126 43388120.36109906 76659831.59710233 1.0 0.2978209586029082 0.5262017423796093 27.118279562373253 -10.160403260642486 5.56114355760253 1.0000125965304036 0.41201135049119286 0.898354060742488 0.09323606455186763 1.4561665459130081e-05 2.1983082757059755e-06 0.09027736267336758 0.03009181043957485 6.911888749969262e-11 10.160403260642486 -0.5880012460392108 YSHLQPGDHLTDITLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSHLQPGDHLTDITLK 16 0 Q15046;Q15046-2;H3BVA8 Q15046 KARS Lysine--tRNA ligase 0 32691100.0 3061800.0 11533000.0 18096300.0 False True 4014049.450513381 9812321.35528189 16223868.467966963 1.0 2.4444943880865573 4.041770951748488 21.936626959211296 -6.969829865816833 0.26221738177087633 0.5635310127279214 5.970260850262072 0.9999810254239686 0.005411519276800139 0.07635793684775566 0.009227464509072223 0.032872059498862516 0.15020998153585888 1.0719391534794767e-07 6.969829865816833 5.406729837534151 YSHLQPGDHLTDITLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSHLQPGDHLTDITLK 16 0 Q15046;Q15046-2;H3BVA8 Q15046 KARS Lysine--tRNA ligase 0 20379900.0 4827100.0 2985100.0 12567700.0 False True 4673866.352720957 4177065.9970908533 9275842.347081661 1.0 0.8937067690562259 1.9846186533942287 22.156185050765544 -6.882967476442319 1.0630710007242343 0.9311273180865497 2.0664815162052426 0.9760029352437549 0.07608057781944018 0.12503570818827128 0.25665610902948216 0.054972388671485774 0.1340031343413614 1.3092799690256507e-07 6.882967476442319 1.135354198118693 YSHLQPGDHLTDITLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSHLQPGDHLTDITLK 16 0 Q15046;Q15046-2;H3BVA8 Q15046 KARS Lysine--tRNA ligase 0 21222100.0 3061800.0 7174200.0 10986100.0 False True 4193830.202033837 6857220.122093154 8391409.445831774 1.0 1.6350733796441452 2.0008939421921 21.999837020734187 -9.404221471671573 0.13872650949016918 5.74419032775199e-20 2.6677870299563415 0.9998410646362503 0.005213128172880227 0.8583080824047892 0.05351079193963128 0.6653806603395459 0.32893420794737105 3.9425619694901733e-10 9.404221471671573 2.6677870299563415 YSK(ub)EEEMDDMDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSKEEEMDDMDR 12 1 Q5TB53;Q9HD45 Q5TB53 TM9SF3 Transmembrane 9 superfamily member 3 1 6986600.0 1859400.0 1759800.0 3367400.0 True False 2437691.406455215 1497244.6996466734 3018973.750381675 1.0 0.6142060047805237 1.2384560828278652 21.21708407241297 -6.739515070327236 1.6883531766686635 0.7703275422860804 1.2387922753482008 0.6028182172253848 0.16209621952687106 0.31869240696608975 1.7835294343024095 0.07595619166004207 0.18649752607754802 1.8217338565352615e-07 6.739515070327236 0.46846473306212044 YSK(ub)EEEMDDMDR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSKEEEMDDMDR 12 1 Q5TB53;Q9HD45 Q5TB53 TM9SF3 Transmembrane 9 superfamily member 3 1 14688600.0 1013100.0 1663500.0 12012000.0 True False 980939.695042902 2327744.225037898 8865696.84772431 1.0 2.37297382989083 9.037963182167445 19.90380492144526 -6.940466606517967 0.6552087500260476 0.9257463916085885 10.860238136170748 0.9982243735257535 0.1479284256673296 0.08755442061528247 0.05364521450387907 0.14451138601250935 0.5724732175734873 1.1469207062951294e-07 6.940466606517967 9.934491744562159 YSK(ub)EEEMDDMDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSKEEEMDDMDR 12 1 Q5TB53;Q9HD45 Q5TB53 TM9SF3 Transmembrane 9 superfamily member 3 1 22256400.0 1571200.0 17109000.0 3576200.0 True False 2383625.270106238 14055765.276772866 2869362.502495856 1.0 5.8968015875022175 1.2037808704587063 21.184726016763214 -6.636208227471378 2.057757155251095 4.211351500682499 1.2229925909490587 0.14032125546447027 2.097183157551054 0.5430404585909644 4.389743683439797 0.8312243295948392 2.3229177948645394 2.310956509899065e-07 6.636208227471378 -2.98835890973344 YSK(ub)EEEMDDMDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSKEEEMDDMDR 12 1 Q5TB53;Q9HD45 Q5TB53 TM9SF3 Transmembrane 9 superfamily member 3 1 8130900.0 1859400.0 1110800.0 5160700.0 True False 2546870.4283956215 1061721.1830756136 3941848.9479527776 1.0 0.41687286924307154 1.5477226104650759 21.28029413393586 -6.766528758924974 1.5875716273465645 0.6640596210539299 1.553293901129414 0.7171901436435915 0.2455542667398198 0.27206848300141584 1.3527030512285132 0.12195283134664103 0.29125259186282804 1.7118718130172098e-07 6.766528758924974 0.8892342800754841 YSK(ub)EEEMDDMDR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSKEEEMDDMDR 12 1 Q5TB53;Q9HD45 Q5TB53 TM9SF3 Transmembrane 9 superfamily member 3 1 8933400.0 1013100.0 3391700.0 4528600.0 True False 842437.5379398068 3373428.238900258 5475509.322119381 1.0 4.004366005757562 6.499602730796895 19.684210196879537 -7.677003008747361 0.2644836481441783 7.853005708428263e-17 8.77954113094503 0.9996942544777928 0.03931472052287177 0.13562238452861852 0.0365414829788407 0.3049453607978352 0.639042158988886 2.103763865056994e-08 7.677003008747361 8.77954113094503 YSK(ub)IFEQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSKIFEQK 8 1 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 3469880.0 1316700.0 1500600.0 652580.0 True False 1726206.4509409368 1276716.3292929875 585057.281589379 1.0 0.7396081323859397 0.33892659900006195 20.719173587686395 -6.964829762572466 0.3609627575375747 1.034149206761503 0.030634085921212594 0.9999095919056461 0.002585307245435043 0.07801878351195941 0.015063974628574875 0.005365382439022686 0.03420364072461872 1.0843518816583792e-07 6.964829762572466 -1.0035151208402904 down YSK(ub)IFEQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSKIFEQK 8 1 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 7243900.0 2270200.0 1879600.0 3094100.0 True False 2198133.7436446548 2630134.081984511 2283662.3889896623 1.0 1.1965305066576934 1.0389096639784963 21.067847737878285 -10.29840917445228 6.9429516103409075 0.9999984175127181 1.1177200853180926 0.4265151876118478 0.06434843956525575 1.577696134798461e-06 1.5939972745171436e-07 0.06230594703109346 0.02076836956588916 5.0302645456013264e-11 10.29840917445228 0.11772166780537452 YSK(ub)IFEQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSKIFEQK 8 1 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 8368600.0 2258500.0 2164300.0 3945800.0 True False 3426309.618466737 1778063.7552469193 3165910.900494422 1.0 0.5189442733557154 0.9240002372906267 21.7082240957734 -10.08449699961089 7.393408505285969 1.0000000474439448 0.7214722553231714 0.38666963347616645 0.16536340481861977 1.2917655606572274e-07 1.613506064602874e-08 0.16011245447803707 0.053370809411222464 8.231955240725279e-11 10.08449699961089 -0.2785277921207734 YSK(ub)IFEQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSKIFEQK 8 1 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 3592000.0 1316700.0 1202000.0 1073300.0 True False 1803519.572479569 1148891.6655175448 819808.6453073642 1.0 0.6370275560347766 0.4545604371680038 20.782383649209287 -13.934119455500708 0.09025820077096332 2.8393906931150648 1.2745116936130619e-11 0.9998464295992994 0.0028093754618347686 11.818072851486669 0.08610451310592922 4.189347020714943 0.4035473132388251 1.1638058730639811e-14 13.934119455500708 -2.83939069310232 YSK(ub)IFEQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSKIFEQK 8 1 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 7287710.0 2270200.0 4238600.0 778910.0 True False 1887771.8869124 4215765.820503778 941776.4797270695 1.0 2.233196632353179 0.49888256428451183 20.84825301331256 -6.715725585632193 1.7745317449039448 1.753651100233703 0.5021800456056624 0.4923722622007123 0.5192224464315203 0.3636769697763838 2.235658772595777 0.23253304639580177 0.5867363724656637 1.924307242306314e-07 6.715725585632193 -1.2514710546280405 YSK(ub)IFEQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSKIFEQK 8 1 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 1 4427300.0 2258500.0 0.0 2168800.0 True False 2923672.771690715 0.0 1774100.6537672253 1.0 0.0 0.6068054780088437 21.47935041786585 -10.116738651073135 6.743483450186044 1.0000007704127714 0.30340273900442155 0.6373036793093123 0.24772729904121915 2.869125561891961e-06 3.757876619875923e-07 0.23986119035335896 0.07995364196563197 7.642955815914641e-11 10.116738651073135 -0.6965980314083497 YSK(ub)LQQAAQQHIQQQLLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSKLQQAAQQHIQQQLLAK 19 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 27304900.0 4347900.0 14383300.0 8573700.0 True False 4209878.294420139 20126626.69791862 6327990.764513313 1.0 4.780809631621625 1.5031291457761533 22.00534709559102 -6.611517480303468 2.147777623070876 3.523339293453981 1.5148992339342235 0.055224167689363335 1.62938923956789 0.6084716089387835 5.320961252095212 0.6259452735179662 1.8088479494851075 2.44614681693883e-07 6.611517480303468 -2.0084400595197573 YSK(ub)LQQAAQQHIQQQLLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSKLQQAAQQHIQQQLLAK 19 1 Q9UKJ3-2;Q9UKJ3 Q9UKJ3-2 GPATCH8 G patch domain-containing protein 8 1 20656400.0 4347900.0 9902700.0 6405800.0 True False 3615471.4946288555 9849352.189567948 7745223.162927252 1.0 2.724223439238878 2.14224428941939 21.785752371025296 -10.143601466549928 5.181388640357489 0.9999476491767458 2.4332338643304254 0.8899460413995163 0.23759199300399383 0.00014370680833870563 2.37529413366259e-05 0.23005577151879125 0.07668248600739991 7.184532826752207e-11 10.143601466549928 1.4332862151536796 YSK(ub)SFSDTLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSKSFSDTLK 10 1 Q9BUL8;C9J363;C9J5C3;C9J6F3 Q9BUL8 PDCD10 Programmed cell death protein 10 1 7458200.0 3271300.0 4186900.0 0.0 True False 4962801.264064747 3439714.9826009925 0.0 1.0 0.6930994814375699 0.0 22.24272325223063 -7.4425855636144505 0.740471871324849 0.9914304503284415 1.0332815064789736e-17 0.9872493299008603 0.0472309735628001 0.11607499122519549 0.14028591603112275 0.04122077214218545 0.0742198922133161 3.6092289845290573e-08 7.4425855636144505 -0.9914304503284415 down YSLATGNWGDQK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSLATGNWGDQKK 13 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 9617800.0 1562600.0 3177500.0 4877700.0 True False 2048583.7322399253 2703429.3857979923 4373002.394202268 1.0 1.319657743665697 2.134646646549721 20.966195430957875 -6.955039724924921 0.5004713630095325 0.9837447775586113 2.5057387687971935 0.9995397136131123 0.010248799081399862 0.08152300336901061 0.028059461269904527 0.012008568439316263 0.06723026435817686 1.1090733636598886e-07 6.955039724924921 1.521993991238582 up YSLATGNWGDQK(ub)K ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSLATGNWGDQKK 13 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 14042000.0 2282800.0 2706300.0 9052900.0 True False 2210333.7635415457 3786939.7031680574 6681673.908821461 1.0 1.7132886289084086 3.02292532423503 21.07583280439308 -6.961682438217123 0.4110360336268018 0.9362106509002279 3.84868731410508 0.9998275967773184 0.010999622804320774 0.07910551224956858 0.018950426254084624 0.016869051985425095 0.10930846290834366 1.0922387036940448e-07 6.961682438217123 2.912476663204852 YSLATGNWGDQK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSLATGNWGDQKK 13 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 65997100.0 7300100.0 13564000.0 45133000.0 True False 11074785.408797462 11143398.223984294 36212442.76750335 1.0 1.0061954080963347 3.269809881709972 23.40077540880103 -6.907496449612105 0.9125864969923301 0.924244148009181 3.5472306931733715 0.9899426701630941 0.10715999474188527 0.10609780512791869 0.1479088681320622 0.08666141881200823 0.2352799895752055 1.2373813055730929e-07 6.907496449612105 2.6229865451641903 up YSLATGNWGDQK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSLATGNWGDQKK 13 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 11604500.0 1562600.0 2732800.0 7309100.0 True False 2140335.4476772053 2612055.859838887 5582841.115639667 1.0 1.2203955518624967 2.608395390404076 21.029405492480766 -6.934819243051755 0.7061203742054505 0.9821872788641076 2.9317803507365436 0.9974034382950758 0.03627924578171485 0.09021158945269217 0.06598129871608098 0.034056988711126085 0.1224335648561517 1.1619321189530124e-07 6.934819243051755 1.9495930718724361 up YSLATGNWGDQK(ub)K ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSLATGNWGDQKK 13 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 13938700.0 2282800.0 7054900.0 4601000.0 True False 1898249.3451870435 7016893.853411994 5563047.827379602 1.0 3.6965079804732324 2.9306201745753526 20.856238079827357 -10.159885815159802 5.684192588328842 0.9999611930371642 3.3135640775244335 0.9240506137888179 0.3126723874454273 0.0001537715227367493 2.2727585966552096e-05 0.3027487372776301 0.10091457911618182 6.920128912471176e-11 10.159885815159802 2.313602884487269 YSLATGNWGDQK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSLATGNWGDQKK 13 1 P30876;C9J2Y9;C9J4M6 P30876 POLR2B DNA-directed RNA polymerase II subunit RPB2;DNA-directed RNA polymerase 1 43029400.0 7300100.0 10474000.0 25255300.0 True False 9450123.356484136 9891112.69261402 20659094.541261222 1.0 1.0466649290696617 2.18611903378871 23.17190173089348 -6.915518830020555 0.857316488289327 0.9705743894436847 2.352169319301749 0.9928425869064972 0.04640170397460551 0.1008805389018471 0.11981247715841585 0.0390584796703901 0.11242201438137933 1.2147339512292647e-07 6.915518830020555 1.3815949298580643 up YSLDPENPTK(ub)SCK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSLDPENPTKSCK 13 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3KRB3;A0A087WWH0;J3QS96;A0A087WY81;J3KSJ0 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 13107500.0 3416700.0 4947000.0 4743800.0 True False 4479326.7873698715 4208926.883254964 4252957.081742765 1.0 0.9396338072771694 0.9494634536900971 22.094850490556887 -9.8458094826041 5.6442353449051 1.000000016958575 0.9445486304844306 0.9769751443682281 0.00401293634480628 8.556178838439765e-10 1.795151969778099e-10 0.0038855100947504536 0.0012951696359430327 1.4262331199215284e-10 9.8458094826041 -0.05545138647414438 YSLDPENPTK(ub)SCK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSLDPENPTKSCK 13 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3KRB3;A0A087WWH0;J3QS96;A0A087WY81;J3KSJ0 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 16833800.0 6161900.0 6698200.0 3973700.0 True False 5966293.85735353 9372826.190651562 2932868.7615552857 1.0 1.5709628816052095 0.49157296500582004 22.508403605680872 -6.76297847436586 1.601135936412155 1.3304162662861172 0.4870218179755311 0.7030496369071828 0.2402633265041869 0.27794442614312054 1.4049740344478627 0.118357249391956 0.283614934045482 1.7259234345823107e-07 6.76297847436586 -0.8433944483105861 down YSLDPENPTK(ub)SCK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSLDPENPTKSCK 13 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3KRB3;A0A087WWH0;J3QS96;A0A087WY81;J3KSJ0 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 28858430.0 12819830.0 5397600.0 10641000.0 True False 19448619.36511332 4434356.108358714 8537801.685884023 1.0 0.2280036451488687 0.43899268763514493 24.213164407813665 -10.309323471801369 6.618761125997893 1.0000178804375155 0.33349816639586044 0.9300953832034775 0.08613591590162976 2.2727522127785493e-05 2.3715918427872537e-06 0.0834029739369544 0.02780024731644453 4.905423736205655e-11 10.309323471801369 -0.666519714041655 YSLDPENPTK(ub)SCK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSLDPENPTKSCK 13 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3KRB3;A0A087WWH0;J3QS96;A0A087WY81;J3KSJ0 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 10759700.0 3416700.0 4564000.0 2779000.0 True False 4679946.322845716 4362347.388870279 2122657.4353015586 1.0 0.9321362015574752 0.4535644831949361 22.158060552079778 -6.932520600533589 0.7258023894156703 1.0066404579899122 0.3486968484114067 0.9970108879113567 0.01329531799054336 0.09134996930188508 0.07142182560722864 0.012299650373997566 0.04271814887171777 1.1680983204089471e-07 6.932520600533589 -0.6579436095785055 down YSLDPENPTK(ub)SCK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSLDPENPTKSCK 13 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3KRB3;A0A087WWH0;J3QS96;A0A087WY81;J3KSJ0 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 17114400.0 6161900.0 6280600.0 4671900.0 True False 5123892.868454543 6246765.161198505 5648772.689575046 1.0 1.2191443735400815 1.102437704026161 22.28880888111515 -10.424666613609453 4.374271113157874 0.9995106747491402 1.1607910387836038 0.7167842538299386 0.047645298316419685 0.00022805212627862793 2.999496033088119e-05 0.046271634000940025 0.015377453908487127 3.7612602683865144e-11 10.424666613609453 0.16128036403446355 YSLDPENPTK(ub)SCK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSLDPENPTKSCK 13 1 A0A087WXM6;J3QQT2;J3KRX5;A0A0A6YYL6;P18621;P18621-3;J3KRB3;A0A087WWH0;J3QS96;A0A087WY81;J3KSJ0 A0A087WXM6 RPL17;RPL17-C18orf32 60S ribosomal protein L17 1 37647830.0 12819830.0 15743700.0 9084300.0 True False 16595522.651628861 14867549.255175445 7431050.612789365 1.0 0.8958771330842169 0.4477744249928762 23.984290729906114 -6.943197601594106 0.6291140931504502 1.0048881151463014 0.314649855228505 0.9985534275093301 0.009112174929200191 0.08633771541520811 0.04819098451045444 0.00910182074957859 0.03805754319036623 1.1397310982057211e-07 6.943197601594106 -0.6902382599177963 down YSLEPVAVELK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSLEPVAVELK 11 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 77616000.0 17264000.0 25878000.0 34474000.0 False True 22633271.18481381 22017103.271653924 30906961.177958615 1.0 0.9727760115571225 1.3655543171636713 24.431941776480976 -6.890284874909598 1.0207215063065094 0.9790393845787194 1.3995228242306446 0.9810790847140549 0.024633861878308336 0.11891130326977208 0.22051256815253664 0.01838216853986167 0.04587318068978417 1.2874048031345475e-07 6.890284874909598 0.42048343965192514 YSLEPVAVELK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSLEPVAVELK 11 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 73238000.0 22751000.0 19355000.0 31132000.0 False True 22028781.9582678 27083552.434991635 22977595.260019403 1.0 1.2294620958298916 1.0430715281284764 24.39288639023771 -10.34661919906653 3.9765270427347317 0.9996562825627894 1.1362668119868615 0.4161066135389556 0.07609363064869411 0.00023245954479338658 3.8195328104915344e-05 0.07386245996829155 0.024559113684352225 4.50174406764475e-11 10.34661919906653 0.13661052942407215 YSLEPVAVELK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSLEPVAVELK 11 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 85565500.0 6312700.0 70595000.0 8657800.0 False True 9576827.42018817 57996770.68874747 6946582.03515146 1.0 6.055948190784869 0.7253531603282218 23.191116373175486 -6.658162380058967 1.9795072680713963 4.259453911336426 0.7477419457347196 0.22770759333780732 2.153677542692165 0.4888716895350573 3.680567583423915 0.879616818062819 2.3868500689891494 2.1970382599859315e-07 6.658162380058967 -3.511711965601706 YSLEPVAVELK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSLEPVAVELK 11 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 86592000.0 17264000.0 29049000.0 40279000.0 False True 23646967.342057634 27765519.12780295 30765929.772044428 1.0 1.1741682866208476 1.3010518146792238 24.495151838003867 -6.974576368023079 0.10030745072613341 0.6880742647933573 1.7903647066476138 0.9999997397210127 6.269454716318284e-05 0.07484393146543446 0.0029450349516474948 0.01140367112772841 0.020752662605598823 1.060287476923893e-07 6.974576368023079 1.1022904418542565 YSLEPVAVELK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSLEPVAVELK 11 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 39257200.0 22751000.0 7967500.0 8538700.0 False True 18918464.540192064 7924577.496075069 10324102.691511886 1.0 0.4188805851151077 0.5457156773784916 24.173291665671986 -9.866880241800413 6.6954123721827115 1.000000013408356 0.4822981312471586 0.9569218415672327 0.05178020958741972 1.037314117302072e-08 1.7295134614755013e-09 0.05013597384293813 0.016711990782923965 1.3586880578474208e-10 9.866880241800413 -0.5177018821611974 YSLEPVAVELK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSLEPVAVELK 11 0 P00558;P00558-2 P00558 PGK1 Phosphoglycerate kinase 1 0 21348400.0 6312700.0 11084000.0 3951700.0 False True 8171914.591920295 10467165.656380933 3232531.147866072 1.0 1.2808706623940966 0.3955659486532236 22.962242695267935 -6.821377289300443 1.3657998890627399 1.151185275752554 0.37564653424425914 0.8875335402865467 0.12387630808422814 0.19170528339011167 0.7022871839776748 0.07126423680407933 0.16420383122793228 1.5087688557170016e-07 6.821377289300443 -0.7755387415082948 down YSLFLPLHELWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSLFLPLHELWK 12 0 K7EQV2;O95707 K7EQV2 POP4 Ribonuclease P protein subunit p29 0 7230100.0 2486500.0 1741600.0 3002000.0 False True 2407567.418541288 2437029.962324017 2215686.141930434 1.0 1.0122374740394935 0.920300767017726 21.199144767406754 -6.873362086962009 1.1162171806335466 1.0070831184397695 0.9145624086897772 0.9679220494909382 0.007300654455564277 0.13366909376995326 0.3092409912434706 0.005065081936781218 0.012066353953653911 1.3385602161740536e-07 6.873362086962009 -0.09252070974999227 YSLFLPLHELWK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSLFLPLHELWK 12 0 K7EQV2;O95707 K7EQV2 POP4 Ribonuclease P protein subunit p29 0 14212600.0 3979700.0 3353400.0 6879500.0 False True 6037495.8550418755 2754959.5697662146 5519763.809608035 1.0 0.4563083165457687 0.9142472213870779 22.525518862810873 -10.139289516489542 7.620328665271596 1.0000000869021761 0.6852777689664256 0.38641459258871813 0.18695277503835814 2.758729589404139e-07 3.1149197947632334e-08 0.18101629461463012 0.0603387486875686 7.256220701141608e-11 10.139289516489542 -0.31472231793575056 YSLFLPLHELWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSLFLPLHELWK 12 0 K7EQV2;O95707 K7EQV2 POP4 Ribonuclease P protein subunit p29 0 4419020.0 233120.0 1051800.0 3134100.0 False True 319310.76383112115 1005327.9981625229 2393890.128815625 1.0 3.148431283995883 7.4970542805807785 18.284601660805638 -6.959809961153737 0.43810415401209246 0.8414022870652826 9.973097108827378 0.9997630854343011 0.041598995482433516 0.0797690788535545 0.02138270372465451 0.05720190367733108 0.36044270092907343 1.096958098736412e-07 6.959809961153737 9.131694821762096 YSLFLPLHELWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSLFLPLHELWK 12 0 K7EQV2;O95707 K7EQV2 POP4 Ribonuclease P protein subunit p29 0 7485800.0 2486500.0 2414900.0 2584400.0 False True 2067634.920627117 2401890.4543798775 3124786.0910845175 1.0 1.1616608088875673 1.5112852176711955 20.97955004284103 -6.958486777795648 0.45626052807305206 0.9894195034800264 1.6975325087374027 0.9997098910045613 0.003634429955933163 0.08024617707899996 0.023162593448255536 0.004718870322123428 0.02889507349561734 1.1003053438577679e-07 6.958486777795648 0.7081130052573763 YSLFLPLHELWK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSLFLPLHELWK 12 0 K7EQV2;O95707 K7EQV2 POP4 Ribonuclease P protein subunit p29 0 3979700.0 3979700.0 0.0 0.0 False True 5151800.1016150275 0.0 0.0 1.0 0.0 0.0 22.296645184903323 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 YSLHDNSEK(ub)VR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSLHDNSEKVR 11 1 Q86XI2;Q86XI2-2;H0Y6U5 Q86XI2 NCAPG2 Condensin-2 complex subunit G2 1 5741300.0 1469200.0 1666800.0 2605300.0 True False 1926135.4277530396 1418119.9371355139 2335728.547802278 1.0 0.7362514165423153 1.2126502187476271 20.877277712837255 -6.7564327917460325 1.6260055278467924 0.8461217349137737 1.2140840072026933 0.6761965784410864 0.11088349144888551 0.2889511081120703 1.5048403409157363 0.05382867149207548 0.12981299496557766 1.7521335606700646e-07 6.7564327917460325 0.36796227228891953 YSLHDNSEK(ub)VR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSLHDNSEKVR 11 1 Q86XI2;Q86XI2-2;H0Y6U5 Q86XI2 NCAPG2 Condensin-2 complex subunit G2 1 7444600.0 1175600.0 1272400.0 4996600.0 True False 1138281.2214909047 1780475.9554783436 3687840.565213065 1.0 1.564179327448011 3.2398325612213683 20.11842560036796 -6.951676415673918 0.540132525403666 0.9753515128722838 3.9060587652009704 0.9993263197594402 0.024688621497112637 0.08281961472192141 0.03323077593950726 0.027149733065231586 0.1387705700455382 1.1176957108343094e-07 6.951676415673918 2.930707252328687 YSLHDNSEK(ub)VR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSLHDNSEKVR 11 1 Q86XI2;Q86XI2-2;H0Y6U5 Q86XI2 NCAPG2 Condensin-2 complex subunit G2 1 27290300.0 3434600.0 9146700.0 14709000.0 True False 5210539.302893894 7514399.9215067085 11801759.70281627 1.0 1.4421539661610974 2.264978539987533 22.31300127183644 -6.961429342087922 0.4147980918862559 0.9615273626056247 2.77638095217453 0.9998195920713305 0.007040331357716233 0.0791944289981555 0.01927351115922985 0.010613832812362656 0.06859683951823596 1.0928754190262839e-07 6.961429342087922 1.8148535895689053 YSLHDNSEK(ub)VR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSLHDNSEKVR 11 1 Q86XI2;Q86XI2-2;H0Y6U5 Q86XI2 NCAPG2 Condensin-2 complex subunit G2 1 6936900.0 1469200.0 1941300.0 3526400.0 True False 2012402.9436371124 1855526.9469793767 2693536.948487736 1.0 0.9220454347109003 1.3384680026454232 20.940487774360147 -6.858307578999033 1.1942267932389796 0.9578795262383587 1.3579939425790482 0.9515521282488798 0.039785349998293494 0.14855709038099615 0.4035527590422049 0.026000757294426288 0.06058379397725941 1.385774038909766e-07 6.858307578999033 0.40011441634068945 YSLHDNSEK(ub)VR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSLHDNSEKVR 11 1 Q86XI2;Q86XI2-2;H0Y6U5 Q86XI2 NCAPG2 Condensin-2 complex subunit G2 1 8693000.0 1175600.0 3274000.0 4243400.0 True False 977563.4879104103 3256362.312161884 5130675.320735188 1.0 3.331100590839903 5.2484318248242445 19.898830875802236 -7.601988604802099 0.23578637021735144 2.9465772476554537e-16 7.412001068392163 0.9998513705094201 0.021178295592756528 0.13691423813068082 0.028094443262369713 0.2357089278662628 0.49288033366433437 2.5004109676509173e-08 7.601988604802099 7.412001068392163 YSLHDNSEK(ub)VR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSLHDNSEKVR 11 1 Q86XI2;Q86XI2-2;H0Y6U5 Q86XI2 NCAPG2 Condensin-2 complex subunit G2 1 27470200.0 3434600.0 7275600.0 16760000.0 True False 4446157.406087639 6870706.4642335875 13709851.97212222 1.0 1.5453133653851925 3.0835282514628957 22.08412759392889 -6.952826518155963 0.5268990697533624 0.9751871572119619 3.723114103024919 0.9994048447039536 0.021522086016840566 0.0823701990626964 0.03141569752217668 0.02412244401571138 0.12715307823248612 1.1147397349312537e-07 6.952826518155963 2.7479269458129574 YSLK(ub)EALCDPTVASR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSLKEALCDPTVASR 15 1 Q9BRX2 Q9BRX2 PELO Protein pelota homolog 1 41918400.0 6393200.0 6433200.0 29092000.0 True False 8276123.428812534 6075186.76476271 23797554.50912766 1.0 0.7340618850140064 2.875447027080184 22.98052373081111 -6.875787225713873 1.1029812859420114 0.8427845312423388 3.0154851565745795 0.9701275261261822 0.16470994933159058 0.13142930605727352 0.2953686736738931 0.11543297870954163 0.27640219924399145 1.3311064084098002e-07 6.875787225713873 2.172700625332241 up YSLLPFWYTLLYQAHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSLLPFWYTLLYQAHR 16 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 10938685400.0 3632492000.0 3772560000.0 3533633400.0 False True 5510755934.736983 3099317192.8541846 2835209209.6434603 1.0 0.5624123495140977 0.5144864412832645 32.3596030872097 -13.999999999999998 0.3123010233039736 5.287291935812711 0.504132462088757 0.9996770420575862 0.003925857150320249 17.435076005837715 0.17789750944991417 48.6356998472919 0.01645285132876529 1.0000000000000041e-14 13.999999999999998 -4.783159473723954 YSLLPFWYTLLYQAHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSLLPFWYTLLYQAHR 16 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 400680000.0 120920000.0 145980000.0 133780000.0 False True 100550337.66427943 145193576.7652388 161752779.47116792 1.0 1.4439889525783154 1.6086746522048796 26.583342685553337 -11.660359134564612 0.17337375906757707 1.5192981407126313e-22 1.7695050518370619 0.9994949340626084 0.00577714633726226 4.52080931710521 0.10883653013194286 1.80581094989119 0.12790283786305784 2.1859532287761036e-12 11.660359134564612 1.7695050518370619 YSLLPFWYTLLYQAHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSLLPFWYTLLYQAHR 16 0 Q14697;F5H6X6;Q14697-2;E9PKU7 Q14697;Q14697-2 GANAB Neutral alpha-glucosidase AB 0 13589911700.0 3632492000.0 5441920000.0 4515499700.0 False True 4702332501.122139 5139072368.16787 3693725087.5395126 1.0 1.0928772831231117 0.7855091248137094 32.13072940930215 -6.825660182057949 1.3471573336117584 1.0497953292901265 0.7779458457083726 0.8969182616525899 0.041325646703055316 0.18622867617988234 0.6624888351476775 0.024095595409293867 0.05547220643398059 1.4939629181820685e-07 6.825660182057949 -0.271849483581754 YSLSTSNSSIAALLCALYPHFPAHSTDNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSLSTSNSSIAALLCALYPHFPAHSTDNR 29 0 Q9H1A4;H0Y564 Q9H1A4 ANAPC1 Anaphase-promoting complex subunit 1 0 517640000.0 205570000.0 139690000.0 172380000.0 False True 311864719.18007815 114761228.09704854 138309017.443162 1.0 0.3679840040860238 0.44349042689660273 28.21634511096799 -10.515999668712503 6.2514681317041445 1.0005601004051297 0.40573721549297803 0.9880368609685226 0.030825368031460534 0.00024084561046925986 1.864673441023654e-05 0.029872712681402052 0.00994884475221342 3.047897314616969e-11 10.515999668712503 -0.5948228849121516 YSLSTSNSSIAALLCALYPHFPAHSTDNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSLSTSNSSIAALLCALYPHFPAHSTDNR 29 0 Q9H1A4;H0Y564 Q9H1A4 ANAPC1 Anaphase-promoting complex subunit 1 0 311033000.0 205570000.0 70531000.0 34932000.0 False True 266114417.39050683 66605887.84826807 28574734.43258794 1.0 0.25029041455701345 0.10737762618346319 27.98747143306044 -13.999999999999984 0.23305736757346823 5.800644570226798 0.03988313712869693 0.9995141184388858 0.008629138436714917 13.388421108062548 0.1528350491140108 29.793303884122896 0.07279913318304035 1.0000000000000368e-14 13.999999999999984 -5.760761433098102 YSNEDTLSVALPYFWEHFDK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSNEDTLSVALPYFWEHFDK 20 0 P26641;P26641-2 P26641 EEF1G Elongation factor 1-gamma 0 29572600.0 5826800.0 20037000.0 3708800.0 False True 8839681.596139913 16461240.800204434 2975754.0543752145 1.0 1.8621983859003113 0.3366358869390339 23.07556297424146 -6.753338641853314 1.6372084690131004 1.5049215404314082 0.3327578141817452 0.6633601900195788 0.3623791684458437 0.294238486108257 1.5526689399649811 0.17476695863109556 0.42285720942319033 1.764661286469887e-07 6.753338641853314 -1.172163726249663 YSNFVSFPLYLNGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSNFVSFPLYLNGR 14 0 Q12931-2;Q12931;I3L0K7;I3L239;I3L2D5 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 45312000.0 12076000.0 21568000.0 11668000.0 False True 15831752.944150371 18350138.47140553 10460707.287359204 1.0 1.1590718056389118 0.6607422010854648 23.916317668506586 -6.8208280042777405 1.3682654832756955 1.0856676183240208 0.6496665528790231 0.8862837754650414 0.07008339886264278 0.19240620571779166 0.7075696958017753 0.0402480088437022 0.0927463371048449 1.5106783168738493e-07 6.8208280042777405 -0.4360010654449977 YSNFVSFPLYLNGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSNFVSFPLYLNGR 14 0 Q12931-2;Q12931;I3L0K7;I3L239;I3L2D5 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 92076000.0 35633000.0 22677000.0 33766000.0 False True 34501849.919518106 31732044.358992726 24921671.64171325 1.0 0.9197200855320379 0.7223285620871814 25.04017038257086 -6.955816851999567 0.4908503746690727 1.0042866580835041 0.6293796141335933 0.9995822217022784 0.0023847104738485164 0.08123068934218278 0.026920981898287292 0.0028472418837871567 0.01628028552438003 1.1070905609765612e-07 6.955816851999567 -0.3749070439499108 YSNFVSFPLYLNGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSNFVSFPLYLNGR 14 0 Q12931-2;Q12931;I3L0K7;I3L239;I3L2D5 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 53815000.0 12718000.0 14967000.0 26130000.0 False True 19294135.810343146 12296021.91229525 20965394.04681414 1.0 0.6372932186837637 1.0866200099812229 24.201659090829583 -6.691872461995024 1.8595280711770992 0.7730109223160669 1.0851137172489158 0.37932698765622763 0.15334087751328387 0.4126470971662886 2.7678250711988865 0.06592976124970085 0.17129638618886694 2.0329539349883688e-07 6.691872461995024 0.31210279493284887 YSNFVSFPLYLNGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSNFVSFPLYLNGR 14 0 Q12931-2;Q12931;I3L0K7;I3L239;I3L2D5 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 82972590.0 12076000.0 30999590.0 39897000.0 False True 16540823.541629314 29629925.611864395 30474150.30450752 1.0 1.7913210631437382 1.842359918042251 23.979527730029478 -11.158701521687526 0.4731839811391643 1.285871017719993e-10 1.8414496781077139 0.9997622449308453 0.0059460778673272345 3.1692748389763397 0.23124171618966244 3.38136373375632 0.01094156040999544 6.9390254176276005e-12 11.158701521687526 1.8414496779791267 YSNFVSFPLYLNGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSNFVSFPLYLNGR 14 0 Q12931-2;Q12931;I3L0K7;I3L239;I3L2D5 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 77641560.0 35633000.0 18886000.0 23122560.0 False True 29630418.309554033 18784257.36942249 27957380.389361996 1.0 0.6339518117219998 0.9435364731367095 24.820575658005136 -10.070134865135229 7.037789490855796 1.0000000603411643 0.7887441424293546 0.3830455850843928 0.12638740877638935 1.1969499165445589e-07 1.580532281449637e-08 0.12237411698700798 0.04079136078010539 8.508737681504361e-11 10.070134865135229 -0.21125591791180964 YSNFVSFPLYLNGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSNFVSFPLYLNGR 14 0 Q12931-2;Q12931;I3L0K7;I3L239;I3L2D5 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 37325000.0 12718000.0 24607000.0 0.0 False True 16463701.709259484 23237598.81870857 0.0 1.0 1.411444353710522 0.0 23.972785412922033 -6.855257608991831 1.394191904616176 1.2180253813011905 2.9113012058568158e-21 0.9023525486244626 0.18520519236975155 0.16972639991028093 0.6631197788695479 0.10696822401035336 0.2245068337116092 1.395540327553972e-07 6.855257608991831 -1.2180253813011905 down YSNSDVIIYVGCGER ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSNSDVIIYVGCGER 15 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 7715900.0 2697700.0 2888200.0 2130000.0 False True 3536710.8245639624 2457291.8181154258 1909608.0324027333 1.0 0.6947957975666226 0.5399389792175522 21.753976832744492 -13.999999999917002 0.08735817814398776 2.581695784238937 0.1344414426564798 0.9998546312602155 0.0023044633524389353 12.187804181269948 0.08521931689990055 3.6137631730439628 0.3652431278164535 1.0000000001911112e-14 13.999999999917002 -2.4472543415824575 YSNSDVIIYVGCGER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSNSDVIIYVGCGER 15 0 P38606;P38606-2 P38606 ATP6V1A V-type proton ATPase catalytic subunit A 0 13219400.0 2697700.0 3259400.0 7262300.0 False True 3695112.5926013044 3115388.9306055633 5547094.311763409 1.0 0.8431106908199449 1.5011976422234907 21.817186894267383 -6.84379734981512 1.2646297296730327 0.9165345066310854 1.5245236509619313 0.9307916400038773 0.07383257062441989 0.16440827559988194 0.5091049824204812 0.04574844035504344 0.10552872186465363 1.4328563417230622e-07 6.84379734981512 0.6079891443308459 YSPPNADGHK(ub)AVFVAR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSPPNADGHKAVFVAR 16 1 E9PK67;E9PNI7;Q53GL7 E9PK67 PARP10 Poly [ADP-ribose] polymerase 10 1 4397400.0 1244800.0 1751700.0 1400900.0 True False 1631944.854660347 1490353.1880731205 1255948.3063816854 1.0 0.9132374686663688 0.7696021730115893 20.63816087709179 -6.963566335969435 0.3818600161290758 1.0096623314810276 0.6680829761821848 0.9998804685590628 0.0010387317376553927 0.07845088800351263 0.01659656812775684 0.0018658513465117626 0.01212634649873673 1.0875110139286865e-07 6.963566335969435 -0.34157935529884276 YSQFINFPIYVWSSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSQFINFPIYVWSSK 15 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 1663190000.0 637080000.0 510540000.0 515570000.0 False True 616856244.119961 714401284.4309275 380526750.2315374 1.0 1.1581325328888084 0.6168807625096128 29.20035907333624 -6.828505058862704 1.334599389813292 1.0845861377109929 0.6027576890618427 0.9028502880666571 0.07082790593658139 0.1826607556529293 0.636823260309525 0.041675569503433284 0.09591359242569114 1.4842085912167276e-07 6.828505058862704 -0.4818284486491502 YSQFINFPIYVWSSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSQFINFPIYVWSSK 15 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 1337680000.0 435850000.0 361330000.0 540500000.0 False True 661216314.9031341 296847838.4158247 433669938.0904347 1.0 0.44894209614188346 0.6558669656449203 29.300547081338713 -10.31625492027164 5.2704208379542 1.0001114959639903 0.5524045308933863 0.8618510750062317 0.08447672422918605 0.00011070139767592181 1.4361450158202013e-05 0.08181445941575387 0.02726474550679983 4.8277534150156615e-11 10.31625492027164 -0.44770696507060403 YSQFINFPIYVWSSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSQFINFPIYVWSSK 15 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 465094000.0 60845000.0 84469000.0 319780000.0 False True 83341040.77429904 80736880.27837065 244254550.07583043 1.0 0.9687529640650772 2.9307835348170306 26.312523780937195 -6.903282159453523 0.9402828382831991 0.9256083506166382 3.151030208009931 0.9881297226800754 0.09997693379264008 0.10902957795294693 0.16410670904127964 0.07922574295570173 0.20974304420591916 1.249447005550586e-07 6.903282159453523 2.225421857393293 up YSQFINFPIYVWSSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSQFINFPIYVWSSK 15 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 2190000000.0 637080000.0 767760000.0 785160000.0 False True 529760247.4293678 763623924.4915725 949333325.830335 1.0 1.4414519175363105 1.7920055920332307 28.980764348770517 -6.973726734362084 0.14352154773267148 0.5535011382116033 2.6891263143804913 0.9999988009689295 0.000354782086670211 0.07511092437801374 0.0043602797503121855 0.01910410454755726 0.044943615949810334 1.0623638047145699e-07 6.973726734362084 2.135625176168888 YSQFINFPIYVWSSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSQFINFPIYVWSSK 15 0 P14625;Q96GW1;A0A1W2PRR1 P14625 HSP90B1 Endoplasmin 0 1228940000.0 435850000.0 456000000.0 337090000.0 False True 564216416.887934 430623199.14378494 275743078.83548194 1.0 0.7632234480502831 0.4887186380651712 29.071673403431163 -6.969184669890669 0.27696840775743337 1.0627250855174242 0.1808867263417523 0.9999753055102321 0.0010381770609091212 0.07656815739768018 0.00997340975216648 0.005160640041574462 0.025293967869161226 1.0735328296442645e-07 6.969184669890669 -0.8818383591756719 down YSQK(ub)EDKYEEEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSQKEDKYEEEIK 13 2 J3KN67;A0A2R2Y2Q3;P06753;P06753-7;A0A494C034;P06753-2;P06753-5;P06753-3;P06753-6;P06753-4 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 1 12326400.0 2000700.0 5958400.0 4367300.0 True False 3035208.170762189 4895076.966808319 3504101.240744411 1.0 1.6127648225126803 1.1544846493558547 21.533364036917824 -10.416239475887096 8.206741415954093 0.9999937895654072 1.3836247359342673 0.4830190988749602 0.18709209724475714 2.1260270054037604e-05 1.5124236951411248e-06 0.18115407595834912 0.06038371473633025 3.8349572241942866e-11 10.416239475887096 0.3836309463688601 YSQK(ub)EDKYEEEIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSQKEDKYEEEIK 13 2 J3KN67;A0A2R2Y2Q3;P06753;P06753-7;A0A494C034;P06753-2;P06753-5;P06753-3;P06753-6;P06753-4 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 1 12774000.0 2000700.0 6825100.0 3948200.0 True False 2589945.5896929894 6445277.185254928 3229668.111953038 1.0 2.4885762893648073 1.2470023018266885 21.304490359010273 -6.601530611549394 2.184728483478541 2.0000871023152427 1.2510660508481632 0.02502589116836318 0.6431534484143893 0.6363580101307217 5.742454139101677 0.24414998792539588 0.715295397780907 2.503049212995987e-07 6.601530611549394 -0.7490210514670794 YSQKEDK(ub)YEEEIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSQKEDKYEEEIK 13 2 J3KN67;A0A2R2Y2Q3;P06753;P06753-7;A0A494C034;P06753-2;P06753-5;P06753-3;P06753-6;P06753-4 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 1 19603700.0 4445000.0 9174500.0 5984200.0 True False 6743389.973028406 7537238.794304315 4801420.24703197 1.0 1.1177225141139802 0.7120187718990376 22.685042601053016 -6.829066749090679 1.3319812916315243 1.0629479906989807 0.7013018972156553 0.903999780491448 0.052802818042426966 0.18197625601644535 0.6317394549344589 0.03112746860406852 0.07163961297035945 1.482290246354508e-07 6.829066749090679 -0.36164609348332544 YSQKEDK(ub)YEEEIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSQKEDKYEEEIK 13 2 J3KN67;A0A2R2Y2Q3;P06753;P06753-7;A0A494C034;P06753-2;P06753-5;P06753-3;P06753-6;P06753-4 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 1 19988500.0 4445000.0 10750000.0 4793500.0 True False 5754140.124049252 10151753.049990546 3921132.1854634825 1.0 1.764251970083524 0.6814453768818092 22.456168923145466 -6.717081178747452 1.7700300727040483 1.4664060340788367 0.6834261209244868 0.4986444400211667 0.32171982092011897 0.3610033357933608 2.2088165872988674 0.14441690605404148 0.36376195473775713 1.918310134757506e-07 6.717081178747452 -0.7829799131543499 YSQKEDKYEEEIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSQKEDKYEEEIK 13 2 J3KN67;A0A2R2Y2Q3;P06753;P06753-7;A0A494C034;P06753-2;P06753-5;P06753-3;P06753-6;P06753-4 J3KN67;P06753-2 TPM3 Tropomyosin alpha-3 chain 0 10251570.0 2652300.0 854570.0 6744700.0 False True 2568104.1882956205 1195804.257523677 4978060.7333371835 1.0 0.46563697180732344 1.9384185252394235 21.292272303282942 -6.8085729472565895 1.4208323499695863 0.7082859474353633 1.9632749677932824 0.8559861121979312 0.23101793313400726 0.20875878878001383 0.8309254955690474 0.12786656316383782 0.29593520586707034 1.5539142621204824e-07 6.8085729472565895 1.254989020357919 YSQNIYIQNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSQNIYIQNR 10 0 Q99959-2;Q99959 Q99959-2 PKP2 Plakophilin-2 0 8385000.0 2506700.0 2030900.0 3847400.0 False True 3286307.974917328 1727897.6363861978 3449307.9548667995 1.0 0.5257868859444512 1.0495997274733728 21.648036257483724 -6.668334471401994 1.9435095295812572 0.6968714471767523 1.0474556220449718 0.27155681732146275 0.20151457956880617 0.46497435624787986 3.384464122866505 0.08352511230099179 0.22362502680865307 2.1461769617373266e-07 6.668334471401994 0.35058417486821947 YSQVLANGLDNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSQVLANGLDNK 12 0 P62269;J3JS69 P62269 RPS18 40S ribosomal protein S18 0 21365100.0 5615600.0 2424500.0 13325000.0 False True 5437335.851824033 3392615.4936004723 9834782.758568646 1.0 0.6239481220315589 1.8087502825983108 22.374468512191932 -6.821341091640354 1.3660302493991388 0.797580235762114 1.8353742908699504 0.8874476281214108 0.1658414907011494 0.19174365374963906 0.7026864673721269 0.09539274777200292 0.21979361037738743 1.5088946141148538e-07 6.821341091640354 1.0377940551078364 YSQYQQAIYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSQYQQAIYK 10 0 O14744-2;O14744;O14744-3;O14744-5;O14744-4;H0YJX6;H0YJ77;G3V5T6 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 2803010.0 408510.0 1390600.0 1003900.0 False True 535560.5660164672 1183127.900516344 900026.058088782 1.0 2.2091393123218968 1.6805308590646093 19.03069021159844 -9.976526712200716 5.517068210680413 0.9999978680210048 1.9448350856946175 0.8098763425843003 0.21580349737183893 5.658906564746732e-06 1.0497134811789653e-06 0.2089513078392355 0.06965027928050702 1.0555365782093934e-10 9.976526712200716 0.9448372176736127 YSQYQQAIYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSQYQQAIYK 10 0 O14744-2;O14744;O14744-3;O14744-5;O14744-4;H0YJX6;H0YJ77;G3V5T6 O14744-2 PRMT5 Protein arginine N-methyltransferase 5;Protein arginine N-methyltransferase 5, N-terminally processed 0 2128710.0 408510.0 0.0 1720200.0 False True 559547.1865676532 0.0 1313924.188631071 1.0 0.0 2.348191931212951 19.09390027312133 -6.791027345548926 1.4925605587780941 0.44184929773068116 2.373757585211504 0.8045323922907779 0.4253839003886298 0.23382700415351368 1.0290933144654824 0.2243331798540882 0.5247526571087971 1.6179781577074844e-07 6.791027345548926 1.9319082874808229 YSSIPVIQGIVNEVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSSIPVIQGIVNEVR 15 0 B4DYU2;Q96MW5;H3BQV3;H3BMQ9;H3BSH5;J3QRV3 B4DYU2 COG8 Conserved oligomeric Golgi complex subunit 8 0 47654000.0 20010000.0 17548000.0 10096000.0 False True 19374793.50292022 24555007.911611088 7451554.726492234 1.0 1.2673687545578274 0.3846004720189206 24.207677598397094 -6.825460368242088 1.3480512702881855 1.14337092388149 0.3629708812903727 0.8964915896348442 0.11891256163701895 0.18647955401546668 0.6643277326455557 0.06928948171583293 0.1595197399491994 1.494650431208166e-07 6.825460368242088 -0.7804000425911173 down YSSIPVIQGIVNEVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSSIPVIQGIVNEVR 15 0 B4DYU2;Q96MW5;H3BQV3;H3BMQ9;H3BSH5;J3QRV3 B4DYU2 COG8 Conserved oligomeric Golgi complex subunit 8 0 17966400.0 5983700.0 8288700.0 3694000.0 False True 8196035.593412315 7922477.826934493 2821553.2803180846 1.0 0.9666231602632744 0.34425830002323926 22.966494818964687 -6.9179872272618175 0.8395266989482816 1.0147536227759182 0.24840239653613574 0.9936030921934051 0.02411901933068917 0.09937074815718104 0.1118604374343327 0.020562437618191043 0.06045681395345578 1.2078493578163516e-07 6.9179872272618175 -0.7663512262397825 down YSSIPVIQGIVNEVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSSIPVIQGIVNEVR 15 0 B4DYU2;Q96MW5;H3BQV3;H3BMQ9;H3BSH5;J3QRV3 B4DYU2 COG8 Conserved oligomeric Golgi complex subunit 8 0 37054200.0 20010000.0 9366000.0 7678200.0 False True 16639201.593303265 9315543.498994555 9283676.120014355 1.0 0.5598551977844752 0.5579399989811249 23.98808287383137 YSSLYAQLCLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSSLYAQLCLR 11 0 D3DQV9;P78344;H0Y3P2;P78344-2;H0YCH5;H0YD77;H0YEC5;H0YE44 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 78589000.0 17455000.0 25430000.0 35704000.0 False True 26480511.131431013 20891817.814503103 28647088.750380874 1.0 0.7889507007931423 1.081817817193802 24.658427633776 -6.713353024665926 1.783441068787482 0.8706981377527944 1.0811947972288278 0.48095790311542463 0.08888973031631994 0.36835907480989677 2.2859291418956005 0.039634921933836234 0.10027695696164599 1.9348485454943823e-07 6.713353024665926 0.21049665947603347 YSSLYAQLCLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSSLYAQLCLR 11 0 D3DQV9;P78344;H0Y3P2;P78344-2;H0YCH5;H0YD77;H0YEC5;H0YE44 D3DQV9 EIF4G2 Eukaryotic translation initiation factor 4 gamma 2 0 51454000.0 17455000.0 16956000.0 17043000.0 False True 22595841.589489248 16012383.6944781 13941348.87594745 1.0 0.7086429434841883 0.616987370031504 24.42955395586845 -13.999999999999998 0.16188566888433414 2.4407593137200787 0.5287341218440046 0.9995315345761798 0.003534370064160522 12.022781513384123 0.1272097921586741 5.438343398264161 0.08062956354715882 1.0000000000000041e-14 13.999999999999998 -1.912025191876074 YSSSFCTHDR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSSSFCTHDR 10 0 K7ES52;P04183;K7ERV3;K7ERJ1;K7ENW5 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 0 4578440.0 646240.0 2270000.0 1662200.0 False True 847226.8981970614 1931324.848390697 1490211.4889482744 1.0 2.279583960920796 1.7589284430410725 19.69238886792132 -9.929002263449155 5.540153409182429 0.9999988120767926 2.019256201983363 0.8363287133306047 0.21255672510352966 3.1189712123679247e-06 6.028200679511319e-07 0.20580740326785144 0.06860238803628806 1.1775998361084976e-10 9.929002263449155 1.0192573899065702 YSSSFCTHDR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSSSFCTHDR 10 0 K7ES52;P04183;K7ERV3;K7ERJ1;K7ENW5 K7ES52;P04183 TK1 Thymidine kinase;Thymidine kinase, cytosolic 0 3014870.0 646240.0 950130.0 1418500.0 False True 885172.3919793395 908150.114940253 1083479.5149245267 1.0 1.0259584722355979 1.2240322051863268 19.75559892944421 -6.9309860520187625 0.7386433163336623 0.9970955464416766 1.2657374164300557 0.9967287337907429 0.005722591936524755 0.0921286826697935 0.0751926388012731 0.00524451069954004 0.01782600984396875 1.1722330128639433e-07 6.9309860520187625 0.268641869988379 YSSSGSPANSFHFK(ub)EAWK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSSSGSPANSFHFKEAWK 18 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 11302900.0 4725800.0 3548900.0 3028200.0 True False 4575782.065772137 4965994.277269015 2235023.575947286 1.0 1.0852777090097345 0.4884462467445199 22.125586910750563 -6.870677451764538 1.1305813055277105 1.0484278543745245 0.45305131834968393 0.9653508217290322 0.04905952595827495 0.1362030253093335 0.3249837843346287 0.033664021798213026 0.07979158023613185 1.346860288764079e-07 6.870677451764538 -0.5953765360248405 down YSSSGSPANSFHFK(ub)EAWK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSSSGSPANSFHFKEAWK 18 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 12552200.0 4725800.0 6727200.0 1099200.0 True False 3929712.0884374133 6690959.238355345 1329037.6378734305 1.0 1.7026588940300451 0.33820229267785895 21.90599218618484 -6.766724502816491 1.5869105804494161 1.404709369239973 0.3314443897167223 0.7179051310138127 0.2959011131101723 0.2717589479193748 1.350086319036973 0.14701781246075746 0.35103710810205 1.7111004172000002e-07 6.766724502816491 -1.0732649795232507 YSTDVSVDEVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSTDVSVDEVK 11 0 P00367;P00367-3;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 4372200.0 922300.0 1950500.0 1499400.0 False True 1209144.2315659043 1659493.00298945 1344256.4712604054 1.0 1.3724524830592961 1.1117420371923072 20.20555491461753 -10.470734567605744 6.314900647815076 0.9998899142127398 1.2420972601258016 0.5348286009399801 0.10643459383126971 0.00016503606763758328 1.383190436920996e-05 0.10310144725493942 0.03435161744740484 3.382715180540432e-11 10.470734567605744 0.2422073459130618 YSTDVSVDEVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSTDVSVDEVK 11 0 P00367;P00367-3;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 3967920.0 1060700.0 533020.0 2374200.0 False True 1027028.6590978251 745857.665662579 1752325.7955267306 1.0 0.7262286782900141 1.706209247428431 19.97004500975479 -6.832155435149207 1.3183631585356315 0.8539235314929101 1.7337387235938841 0.9100974361516975 0.1237894728045642 0.1781666172759334 0.6048819681908786 0.07370893358745448 0.1696125583531227 1.4717856521616215e-07 6.832155435149207 0.879815192100974 YSTDVSVDEVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSTDVSVDEVK 11 0 P00367;P00367-3;P49448 P00367 GLUD1;GLUD2 Glutamate dehydrogenase 1, mitochondrial;Glutamate dehydrogenase 2, mitochondrial 0 5335800.0 922300.0 1894000.0 2519500.0 False True 1263299.2342203287 1810316.817379558 1924445.9907312975 1.0 1.4330071358721534 1.5233492893859064 20.26876497614042 -11.977959025636105 0.25754596623482423 1.0730990563325755e-08 1.560506372098834 0.9993824635971147 0.005676117216854955 5.121985199200829 0.14836530226436392 2.7751737863056096 0.03993945006894786 1.0520611279096144e-12 11.977959025636105 1.5605063613678434 YSTHLHLAEDCMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSTHLHLAEDCMK 13 0 A0A0D9SG72;P61764;A0A1B0GWF2;A0A1B0GVQ5;A0A2R8Y5D4;A0A1B0GTP9;P61764-2;A0A1B0GW76 A0A0D9SG72 STXBP1 Syntaxin-binding protein 1 0 3975900.0 1049100.0 1056300.0 1870500.0 False True 1375380.2594988502 898704.1574251519 1676958.6031029639 1.0 0.6534223180959529 1.2192690650613238 20.391399113524468 -6.740977672916092 1.6833081772719807 0.7940204576548968 1.2196598462829638 0.6092563425643692 0.14561380860045994 0.3160432917512637 1.7587594166063822 0.06842617632729099 0.16771940235577062 1.815609000851797e-07 6.740977672916092 0.42563938862806694 YSTHLHLAEDCMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSTHLHLAEDCMK 13 0 A0A0D9SG72;P61764;A0A1B0GWF2;A0A1B0GVQ5;A0A2R8Y5D4;A0A1B0GTP9;P61764-2;A0A1B0GW76 A0A0D9SG72 STXBP1 Syntaxin-binding protein 1 0 3539560.0 1049100.0 890560.0 1599900.0 False True 1436980.6208614833 851212.1145119007 1222036.5709747984 1.0 0.5923615824419338 0.8504196599688144 20.45460917504736 -10.49367055037748 6.001948684412127 1.0002547020015855 0.7213906212053742 0.6084816061564607 0.10535176899074015 0.00035938477425380736 3.0318003969845598e-05 0.10209839589936032 0.03400213723288563 3.208702477614013e-11 10.49367055037748 -0.2788640807962113 YSTIPK(ub)FGIEK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSTIPKFGIEK 11 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 10468600.0 4035500.0 5337400.0 1095700.0 True False 5290579.579837587 4541080.725022254 982327.4746965617 1.0 0.8583333180221548 0.1856748320052144 22.334994346702334 -6.942405910022535 0.6513348897857645 1.0073786626765824 5.217193559494456e-20 0.9982893522569486 0.014692104404455593 0.08701392895241027 0.05264910977884578 0.014412521833561185 0.057422121875241594 1.1418106513066003e-07 6.942405910022535 -1.0073786626765824 down YSTIPK(ub)FGIEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSTIPKFGIEK 11 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 14693700.0 4701300.0 5050600.0 4941800.0 True False 4552059.804861514 7067330.918531052 3647394.329177828 1.0 1.5525566933420505 0.801262392309187 22.11808808118887 -6.709586763382967 1.7964057583551722 1.3398329638068074 0.8030263163619323 0.4632914502390758 0.23285830172666863 0.3758920762043268 2.3642828324115084 0.10315815375955098 0.26222828866341347 1.9517007841688464e-07 6.709586763382967 -0.536806647444875 YSTIPK(ub)FGIEK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSTIPKFGIEK 11 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 60241400.0 10991200.0 26941000.0 22309200.0 True False 16674453.964353157 22133168.05900623 17899776.841530297 1.0 1.3273698860737975 1.0734850376388125 23.991136182693776 -10.27123904070564 5.384899834551045 0.9999799833311813 1.2004274618469843 0.4538381398128296 0.10364805537204203 2.9691684321460434e-05 4.018288323663841e-06 0.10036873614392589 0.033452266023310195 5.3550182998201555e-11 10.27123904070564 0.20044747851580302 YSTIPK(ub)FGIEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSTIPKFGIEK 11 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 9583700.0 4035500.0 2935300.0 2612900.0 True False 5527533.4052869305 2805608.740260939 1995786.834364681 1.0 0.5075697484844602 0.3610628264056744 22.398204408225226 -13.999999999999998 0.16990467330461345 3.482720391661067 0.23169572766476154 0.9995138601567736 0.006025679098986586 12.090587109588979 0.1305271125048623 9.893185546464599 0.11954895928111323 1.0000000000000041e-14 13.999999999999998 -3.2510246639963056 YSTIPK(ub)FGIEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSTIPKFGIEK 11 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 16406600.0 4701300.0 9624000.0 2081300.0 True False 3909339.2529033828 9572153.601785574 2516490.2071560915 1.0 2.448534901307565 0.6437124138784189 21.898493356623145 -6.6930277669993306 1.8556988508326744 1.9055433519559448 0.6497163573828707 0.3846490239654389 0.6122553914307487 0.41017406657615907 2.7408593092727958 0.2637162730779974 0.6841156662606658 2.0275530819891012e-07 6.6930277669993306 -1.255826994573074 YSTIPK(ub)FGIEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSTIPKFGIEK 11 1 O14964;O14964-2;I3L1P5 O14964 HGS Hepatocyte growth factor-regulated tyrosine kinase substrate 1 67328500.0 10991200.0 32638000.0 23699300.0 True False 14228325.068942657 30821666.608892173 19386270.57535298 1.0 2.166218895024347 1.3625124869875935 23.762262504786225 -10.152038139269704 4.7890117058215536 0.9999335642399089 1.764365691010452 0.5466902366272499 0.32811176713127804 0.00023276004431553682 4.121373095953214e-05 0.31772029248850475 0.10589761748065306 7.046311863044861e-11 10.152038139269704 0.7644321267705431 YSTSLSWIHLLKPLVHLQLPR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSTSLSWIHLLKPLVHLQLPR 21 1 Q9NUY8-2;Q9NUY8;C9IZ32;C9JAM5 Q9NUY8-2 TBC1D23 TBC1 domain family member 23 0 413821000.0 82814000.0 171990000.0 159017000.0 False True 125634892.51437 141297040.73599663 127587220.25037302 1.0 1.1246639998504813 1.0155396936068515 26.904661957933936 -10.688093449957961 2.9099511539886036 0.991330845724007 1.070101846781364 0.35493989222678257 0.04454981197324379 33075591.126674503 23858602.948226925 2067917.2398118784 0.016303560236734883 2.0507208644496656e-11 10.688093449957961 0.07877100105735713 YSTSLSWIHLLKPLVHLQLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSTSLSWIHLLKPLVHLQLPR 21 1 Q9NUY8-2;Q9NUY8;C9IZ32;C9JAM5 Q9NUY8-2 TBC1D23 TBC1 domain family member 23 0 354727000.0 82814000.0 154159000.0 117754000.0 False True 107204355.50798985 145579916.13334814 96323980.25807165 1.0 1.3579664319002243 0.898508085810867 26.675788280026385 -6.698821530973898 1.8352462239750251 1.2225447599127401 0.8999138415446114 0.4118651676687892 0.15113575466146817 0.39800162480758433 2.60537874830544 0.06572161454530548 0.1692540301155719 2.0006838619908116e-07 6.698821530973898 -0.32263091836812874 YSVALVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSVALVLK 8 0 H0YEQ6;Q9GZQ3 H0YEQ6 COMMD5 COMM domain-containing protein 5 0 4743080.0 1544000.0 738380.0 2460700.0 False True 1494986.5651428716 1033218.984600831 1816168.8505823538 1.0 0.6911225884508797 1.214839579784978 20.511701088872073 -6.746905093322144 1.6615118481506106 0.8177041615263188 1.21562733238394 0.635491302251714 0.12977655313921535 0.30545796513215845 1.6581447260656943 0.0617305666656307 0.150342857107231 1.7909971991478721e-07 6.746905093322144 0.3979231708576212 YSVALVLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSVALVLK 8 0 H0YEQ6;Q9GZQ3 H0YEQ6 COMMD5 COMM domain-containing protein 5 0 4845100.0 1087200.0 1056300.0 2701600.0 False True 1489167.2204752706 1009629.1732830142 2063537.7211985239 1.0 0.6779824047972188 1.3856991295711854 20.50607433439588 -6.7829615350973125 1.5240307894621141 0.8183713268799974 1.3918671605040571 0.7778489892672527 0.1363619646014075 0.24598665124189878 1.1286272877508616 0.07045488731516238 0.16585827880289997 1.6483083736095477e-07 6.7829615350973125 0.5734958336240598 YSVDIPLDK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSVDIPLDK 9 0 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 0 17488100.0 1587400.0 8806500.0 7094200.0 False True 2081096.7724034647 7492604.527468135 6360160.236371594 1.0 3.6003152889497323 3.0561578494142903 20.988912622249643 -10.116359811635235 5.189409898254206 0.9999395417733521 3.328236569184847 0.9606433282951342 0.22215134444342952 0.0001553949334795326 2.6459901315042653e-05 0.21510258242761604 0.0716990381124925 7.64962575172913e-11 10.116359811635235 2.3282970274114945 YSVDIPLDK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSVDIPLDK 9 0 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 0 16716200.0 6438000.0 1908900.0 8369300.0 False True 6233629.213983031 2671133.724781991 6177129.256381876 1.0 0.4285037869737599 0.9909362659116111 22.57164091308167 -10.89827001508047 11.068564536144168 1.0217176170810083 0.7097200264877466 0.2620833411996971 0.2296120980277304 0.10126936081741301 0.0009307542314268182 0.18296083545451539 0.07410698597909542 1.2639502639203396e-11 10.89827001508047 -0.3119975905932617 YSVDIPLDK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSVDIPLDK 9 0 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 0 16997800.0 1587400.0 7856300.0 7554100.0 False True 2174304.677872003 7509182.688690088 5769977.161573053 1.0 3.453601864132189 2.653711423377952 21.052122683772534 -10.044342083542723 5.648330099068469 0.9999917840760865 3.053656643755744 0.8978432369033126 0.32655390499868164 3.378468435440317e-05 5.717262764554063e-06 0.3161857273249938 0.10539481964122843 9.029379705522451e-11 10.044342083542723 2.0536648596796576 YSVDIPLDK(ub)TVVNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSVDIPLDKTVVNK 14 1 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 66163000.0 14028000.0 18238000.0 33897000.0 True False 18390843.84734523 15516961.491167182 30389663.602983784 1.0 0.8437329803877976 1.6524344317876756 24.13248434224577 -6.8566082072580805 1.2027187188192983 0.9158651876263953 1.6891400605523665 0.9493867085802429 0.07879758372812642 0.15033710341215317 0.41517014935445207 0.0511644430889462 0.11901613137954954 1.3912071234732243e-07 6.8566082072580805 0.7732748729259712 YSVDIPLDK(ub)TVVNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSVDIPLDKTVVNK 14 1 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 96647000.0 30769000.0 23834000.0 42044000.0 True False 29792254.937099073 33351040.49266804 31031415.107036423 1.0 1.1194533801849742 1.041593366213924 24.828433987646328 -10.238069717024702 4.198344643814698 0.9999490579963165 1.080523373203397 0.587817903854992 0.03178621761238467 3214929.6081093797 7882602.498852425 878.7288422120446 0.010881267780183753 5.7800325345288016e-11 10.238069717024702 0.08057431520708047 YSVDIPLDK(ub)TVVNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSVDIPLDKTVVNK 14 1 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 101808000.0 32992000.0 33452000.0 35364000.0 True False 50051276.0382797 27482229.23833107 28374289.899408147 1.0 0.5490814902963193 0.5669044257274723 25.576903514703993 -10.203512433838323 8.26808894950537 1.0000001148151385 0.5579929580237446 0.9987820418877235 0.007276182920816066 1.5402162280962757e-08 1.4728633038084982e-09 0.007045135708688347 0.0023483779396899587 6.258749448835521e-11 10.203512433838323 -0.4420071567913939 YSVDIPLDK(ub)TVVNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSVDIPLDKTVVNK 14 1 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 111498800.0 14028000.0 17321800.0 80149000.0 True False 19214530.69244581 16556465.600467404 61219456.920469485 1.0 0.861663803580515 3.186102117213714 24.195694403768663 -6.892765213304554 1.0059158978302898 0.8832576392184647 3.3971750245697456 0.9826088053184038 0.14040058975815398 0.11692691396560466 0.20898814418195638 0.10594726913571101 0.26688893537795794 1.2800731455955416e-07 6.892765213304554 2.513917385351281 up YSVDIPLDK(ub)TVVNK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSVDIPLDKTVVNK 14 1 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 117651400.0 30769000.0 39826400.0 47056000.0 True False 25585786.797818504 39611847.27827856 56895192.037638426 1.0 1.548197348445659 2.2237030460399767 24.608839263080604 -6.968318837615936 0.29559890945894807 0.8765450891976243 2.9163901259086016 0.9999661374982182 0.0029123334160897968 0.0768520895572099 0.010972512039163664 0.011458884913270769 0.06087182855587692 1.0756752159191923e-07 6.968318837615936 2.039845036710977 YSVDIPLDK(ub)TVVNK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSVDIPLDKTVVNK 14 1 P61353;K7ELC7 P61353 RPL27 60S ribosomal protein L27 1 121497000.0 32992000.0 38903000.0 49602000.0 True False 42708794.36954623 36738013.851514615 40574944.959499225 1.0 0.8601978677654006 0.9500372360881122 25.348029836796442 -10.394502749787286 5.124295833825422 1.000074892135882 0.9051175519285919 0.5979457407499876 0.03667676853412112 3.1405667777213776e-05 3.71097423970802e-06 0.03554013165900089 0.011837376143776621 4.031783936633201e-11 10.394502749787286 -0.09495734020729008 YSVHNAGISFSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSVHNAGISFSVK 13 0 A0A669KBB4;A0A669KBK2;H0Y818;A0A669KAW3;P40692;P40692-3;A0A669KB03;H0Y5L7 A0A669KBB4 MLH1 DNA mismatch repair protein Mlh1 0 7463400.0 3031600.0 2904100.0 1527700.0 False True 3974456.958056166 2470819.600093137 1369628.2587331724 1.0 0.6216747661802757 0.344607646575957 21.922326323447187 -7.924747888862874 0.2082237915579159 1.2284229241410904 3.729633434471018e-13 0.9998353541648576 0.003446842657419876 0.11234986475831835 0.03404802646882727 0.06844238859003607 0.09744149669423693 1.1891923620056434e-08 7.924747888862874 -1.2284229241407174 down YSVHNAGISFSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSVHNAGISFSVK 13 0 A0A669KBB4;A0A669KBK2;H0Y818;A0A669KAW3;P40692;P40692-3;A0A669KB03;H0Y5L7 A0A669KBB4 MLH1 DNA mismatch repair protein Mlh1 0 7159300.0 2542900.0 1756300.0 2860100.0 False True 2462177.0314130876 2457599.748983509 2110954.008839188 1.0 0.99814096128297 0.857352652513241 21.23150306516757 -6.909778814356455 0.8972390664529608 1.0043896362007565 0.8392439022468821 0.9908378426515617 0.006395064834251543 0.10456448136658032 0.13956170825182793 0.0052300063625302295 0.014415168191374365 1.2308955047625916e-07 6.909778814356455 -0.16514573395387444 YSVHNAGISFSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSVHNAGISFSVK 13 0 A0A669KBB4;A0A669KBK2;H0Y818;A0A669KAW3;P40692;P40692-3;A0A669KB03;H0Y5L7 A0A669KBB4 MLH1 DNA mismatch repair protein Mlh1 0 20432500.0 6461700.0 7352900.0 6617900.0 False True 9802871.313547276 6040717.546530084 5309869.16427139 1.0 0.6162192028555952 0.5416646811361595 23.224772953560826 -13.999999999999991 0.23037900933718192 3.426951849737552 0.5055461091641905 0.9995103133380348 0.004443665674834486 13.303092698391977 0.15197278919426763 14.771553157743778 0.03860936108871907 1.0000000000000205e-14 13.999999999999991 -2.9214057405733618 YSVHNAGISFSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSVHNAGISFSVK 13 0 A0A669KBB4;A0A669KBK2;H0Y818;A0A669KAW3;P40692;P40692-3;A0A669KB03;H0Y5L7 A0A669KBB4 MLH1 DNA mismatch repair protein Mlh1 0 8743200.0 3031600.0 2377000.0 3334600.0 False True 4152464.445909525 2271976.2803121465 2547036.158242743 1.0 0.5471392494522634 0.6133794018999383 21.98553638497008 -10.551844188400564 6.331751229635177 1.00061005633978 0.5802593256761515 0.9816639965874407 0.02704242899682895 0.0002332048459931299 1.6505988204011373e-05 0.02621969363201329 0.008727906428809593 2.8064403224534316e-11 10.551844188400564 -0.4203507306636285 YSVHNAGISFSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSVHNAGISFSVK 13 0 A0A669KBB4;A0A669KBK2;H0Y818;A0A669KAW3;P40692;P40692-3;A0A669KB03;H0Y5L7 A0A669KBB4 MLH1 DNA mismatch repair protein Mlh1 0 25050600.0 6461700.0 10601000.0 7987900.0 False True 8364798.029149391 10011045.030972071 6534184.162775359 1.0 1.1968065452490173 0.7811526518638269 22.995899275653276 -6.777924068245778 1.543741997987057 1.1117349008844866 0.7780586977763198 0.7600673569874685 0.08315805607199962 0.2538027758614364 1.1945081408944018 0.04243204353064162 0.10030599659356086 1.667538738413256e-07 6.777924068245778 -0.3336762031081668 YSVQLLTPANLLAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YSVQLLTPANLLAK 14 0 Q9Y265;H7C4G5 Q9Y265 RUVBL1 RuvB-like 1 0 117674000.0 34039000.0 46917000.0 36718000.0 False True 44625458.634144925 39917166.48103366 32918773.58392657 1.0 0.8944931369398019 0.7376680171246229 25.411363660598234 -6.965408721254734 0.35097655075223666 1.0149859946411612 0.6118754585130077 0.9999213111219502 0.0009560416708850566 0.07782263991715756 0.01437308051939757 0.0021473812459890814 0.013470852517372709 1.082907293501445e-07 6.965408721254734 -0.4031105361281535 YSVQLLTPANLLAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSVQLLTPANLLAK 14 0 Q9Y265;H7C4G5 Q9Y265 RUVBL1 RuvB-like 1 0 153127600.0 59154600.0 33678000.0 60295000.0 False True 57276769.6025909 47125801.02844986 44501930.688772686 1.0 0.8227733748852718 0.776962999092736 25.771446791420118 -13.999999999999998 0.1899483976579767 1.949871900107692 0.7440811184178416 0.9994894326352042 0.002173224802281848 12.349808311775325 0.13821001503084998 4.34171540729847 0.03151715053860466 1.0000000000000041e-14 13.999999999999998 -1.2057907816898505 YSVQLLTPANLLAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSVQLLTPANLLAK 14 0 Q9Y265;H7C4G5 Q9Y265 RUVBL1 RuvB-like 1 0 120145000.0 49914000.0 41317000.0 28914000.0 False True 75723187.20219123 33943658.53880561 23199135.226543594 1.0 0.4482597707908334 0.3063676541321318 26.174231799817676 -13.999999999999952 0.1906708659197627 3.9645460659550165 0.20525711612214745 0.9994890526586544 0.006763118592857376 12.361716002011875 0.1384740707258863 13.618459904759764 0.09706302696155195 1.0000000000001104e-14 13.999999999999952 -3.759288949832869 YSVQLLTPANLLAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YSVQLLTPANLLAK 14 0 Q9Y265;H7C4G5 Q9Y265 RUVBL1 RuvB-like 1 0 183501300.0 34039000.0 62507300.0 86955000.0 False True 46624138.1693872 59745520.80200069 66418019.89443941 1.0 1.281428958213512 1.4245415036550448 25.474573722121125 -12.245802579793114 0.10323187878884879 1.2018251258362424e-15 1.7442938231816476 0.9998310123962075 0.002292561213200811 6.29826025625269 0.07840565121644968 1.6025467838643335 0.24617280355954874 5.678026566811846e-13 12.245802579793114 1.7442938231816465 YSVQLLTPANLLAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSVQLLTPANLLAK 14 0 Q9Y265;H7C4G5 Q9Y265 RUVBL1 RuvB-like 1 0 114804600.0 59154600.0 24757000.0 30893000.0 False True 49189670.89311429 24623629.127120275 37352583.46690677 1.0 0.5005853603010619 0.7593582715377649 25.551852066854394 -10.074850426757862 5.010758638744143 1.0000085611787546 0.629971815917666 0.7316359594689077 0.10564359863680269 146707925.7201018 11.65701596473022 14491.315474190793 0.03616461376745353 8.416849723446724e-11 10.074850426757862 -0.37003674526108854 YSVQLLTPANLLAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSVQLLTPANLLAK 14 0 Q9Y265;H7C4G5 Q9Y265 RUVBL1 RuvB-like 1 0 108258000.0 49914000.0 35532000.0 22812000.0 False True 64614656.952034764 33554612.96486173 18660450.07088619 1.0 0.519303429712089 0.28879593193133185 25.945358121910125 -10.348503396154452 0.16133822515496604 1.7843777908396707 1.778545392336093e-18 0.9996403836376749 0.0056184389504766764 2.049567590374954 0.0810147257723873 0.8372990183736545 0.18599033877569487 4.482255448884615e-11 10.348503396154452 -1.7843777908396707 YSYISYSNNK(ub)DGETSLVTGEADEGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YSYISYSNNKDGETSLVTGEADEGR 25 1 Q96JK2-2;Q96JK2-3;Q96JK2 Q96JK2-2 DCAF5 DDB1- and CUL4-associated factor 5 1 21244600.0 5467500.0 9559200.0 6217900.0 True False 5293937.205258184 13376238.410569469 4589245.456998419 1.0 2.5267089298459315 0.8668870217123406 22.335909651539446 -6.664912134753975 1.9557756492581366 1.9787430693357788 0.8737768108846937 0.2565677803196804 0.6492865210423263 0.4728990023685442 3.4823353211671755 0.26776167886049507 0.7200763008016159 2.1631561231608867e-07 6.664912134753975 -1.104966258451085 YSYISYSNNK(ub)DGETSLVTGEADEGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YSYISYSNNKDGETSLVTGEADEGR 25 1 Q96JK2-2;Q96JK2-3;Q96JK2 Q96JK2-2 DCAF5 DDB1- and CUL4-associated factor 5 1 17185400.0 5467500.0 9290200.0 2427700.0 True False 4546468.501318619 9240151.848639676 2935320.8455834514 1.0 2.03238004309493 0.6456265659230052 22.116314926973722 -6.707364253162324 1.8044676931332297 1.6363819162406557 0.649114498510629 0.4526299178179878 0.435222809894021 0.380401926654525 2.412787973264876 0.19205312886703496 0.4894952738361177 1.9617142500218357e-07 6.707364253162324 -0.9872674177300267 YSYISYSNNK(ub)DGETSLVTGEADEGR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSYISYSNNKDGETSLVTGEADEGR 25 1 Q96JK2-2;Q96JK2-3;Q96JK2 Q96JK2-2 DCAF5 DDB1- and CUL4-associated factor 5 1 27636000.0 9075500.0 9052800.0 9507700.0 True False 11748413.654850151 8549003.721949248 7777396.157240234 1.0 0.7276730265979291 0.6619954306792267 23.48596263233923 -13.999999999999993 0.1997742421246983 2.512530372561215 0.6192464023994049 0.9994869201443509 0.0033146441423788954 12.526399356447696 0.14172459614463803 7.40256287346381 0.04189042071617432 1.0000000000000164e-14 13.999999999999993 -1.8932839701618103 YSYVCPDLVK(ub)EFNKYDTDGSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YSYVCPDLVKEFNKYDTDGSK 21 2 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 47769500.0 9374500.0 11365000.0 27030000.0 True False 14221801.86775136 9336826.954849707 21687508.65233014 1.0 0.6565150493357262 1.5249480237456858 23.761600926706432 -6.799384974751818 1.4583391865599187 0.810337935786971 1.5367678109291738 0.8303930197500824 0.14706865698789953 0.2216292271753658 0.9306124666146669 0.0793369736333238 0.1845849517301622 1.58713922571791e-07 6.799384974751818 0.7264298751422028 YSYVCPDLVK(ub)EFNKYDTDGSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YSYVCPDLVKEFNKYDTDGSK 21 2 P61158;B4DXW1 P61158 ACTR3 Actin-related protein 3 1 43007300.0 9374500.0 8299800.0 25333000.0 True False 12135475.049021307 7837908.8338894285 20722653.938530546 1.0 0.6458674919793547 1.707609620127872 23.53272724879888 -6.816778259077939 1.385720477678773 0.8084789878598136 1.7292314048447885 0.8768167508493072 0.1549163470350848 0.19770389392036034 0.7468094261683238 0.08786934660480517 0.20272268757501466 1.524831099286728e-07 6.816778259077939 0.9207524169849749 YTALDK(ub)WTNQLNSLNQAVVSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTALDKWTNQLNSLNQAVVSK 21 1 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 1 18042600.0 5368100.0 7712200.0 4962300.0 True False 7037631.084754355 6561569.821920145 4448848.797742764 1.0 0.9323548993829042 0.632151464628534 22.746658458781877 -6.942496590891837 0.6359180159863147 1.0032790102706686 0.5448832361089219 0.9984729035566461 0.006247203173366982 0.0866460499425004 0.04956091557313765 0.0062030356149715095 0.02556728711432198 1.1415722656538508e-07 6.942496590891837 -0.4583957741617467 YTALDK(ub)WTNQLNSLNQAVVSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTALDKWTNQLNSLNQAVVSK 21 1 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 1 118831000.0 36198000.0 51462000.0 31171000.0 True False 35048914.30378347 72011044.97078466 23006379.99004451 1.0 2.054587036466667 0.6564077788726543 25.062866419351657 -6.7049103512223365 1.813119900089425 1.6516647844814145 0.6601251688167548 0.44104123625862757 0.44476557585838816 0.38538118158609613 2.4662363990664704 0.19544160843536298 0.499644513786101 1.9728299334117098e-07 6.7049103512223365 -0.9915396156646598 YTALDK(ub)WTNQLNSLNQAVVSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YTALDKWTNQLNSLNQAVVSK 21 1 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 1 100104000.0 33099000.0 24720000.0 42285000.0 True False 50213602.86102748 20308522.861758463 33927351.215826124 1.0 0.40444265507027805 0.6756605637266136 25.581574907306518 -10.4256802683366 6.0825128290702235 1.0001477073027745 0.5400516093984642 0.7931577115089986 0.11072424755213349 0.00022185385005829667 2.0947824656347083e-05 0.10724225717275843 0.03573609723256331 3.752491625236146e-11 10.4256802683366 -0.4600960979043103 YTALDK(ub)WTNQLNSLNQAVVSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTALDKWTNQLNSLNQAVVSK 21 1 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 1 36001400.0 5368100.0 8217300.0 22416000.0 True False 7352831.637447855 7854232.515022727 17121802.472011425 1.0 1.0681915352204236 2.3285998260602563 22.809868520304768 -6.9180779649495605 0.8388707891014334 0.9702171243342441 2.5231223443790474 0.993629912068373 0.04875524340091951 0.09931571482814584 0.11157577879676506 0.04158561429749177 0.12236690017380379 1.2075970267044744e-07 6.9180779649495605 1.5529052200448032 up YTALDK(ub)WTNQLNSLNQAVVSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YTALDKWTNQLNSLNQAVVSK 21 1 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 1 102018000.0 36198000.0 42587000.0 23233000.0 True False 30100240.843297977 42357575.37814233 28090912.88274513 1.0 1.4072171581169766 0.9332454523864637 24.843271694785933 -6.679309190756873 1.9041742248085822 1.2578114773636568 0.9350533874949312 0.320989126876534 0.17261471309077253 0.44008945582285647 3.084505486320625 0.07275203743809072 0.1920603814137254 2.092622108139913e-07 6.679309190756873 -0.3227580898687257 YTALDK(ub)WTNQLNSLNQAVVSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YTALDKWTNQLNSLNQAVVSK 21 1 B4DIH5;P61201;P61201-2 B4DIH5 COPS2 COP9 signalosome complex subunit 2 1 83116000.0 33099000.0 30225000.0 19792000.0 True False 42847307.97883152 28542952.18008964 16190059.083069382 1.0 0.6661550871338552 0.3778547555675608 25.352701229398967 -7.39870861165383 0.22183965149034077 1.1586037214951161 2.148406624488286e-15 0.9999466256916173 0.0018572388054362908 0.11907687137505824 0.01739941229513801 0.023077423394872284 0.05633906222726897 3.992927165431389e-08 7.39870861165383 -1.158603721495114 down YTATK(ub)VVYSAPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTATKVVYSAPR 12 1 O15551 O15551 CLDN3 Claudin-3 1 5568400.0 2108200.0 2252600.0 1207600.0 True False 2763870.6158378394 1916520.8605660303 1082649.1361171557 1.0 0.6934191671577421 0.39171484001936957 21.398258650224687 -7.107484706814655 0.2391038536527806 1.1172054762191885 4.8589121972119704e-14 0.9999843958559981 0.000980954132336627 0.07729403267571608 0.009293101900744977 0.008897070574126522 0.031372402690948285 7.807559330844274e-08 7.107484706814655 -1.11720547621914 down YTATK(ub)VVYSAPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTATKVVYSAPR 12 1 O15551 O15551 CLDN3 Claudin-3 1 4912100.0 2108200.0 1579000.0 1224900.0 True False 2887658.511962807 1509234.5589452584 935603.8476073709 1.0 0.5226499437841761 0.32400086219731705 21.461468711747578 -13.999999999999574 0.12025590326101679 3.274699530131351 0.008035456014667694 0.9996916871023578 0.004981192818215153 11.962789932104686 0.10675770248673294 6.5011195423338926 0.2803887155512064 1.0000000000009817e-14 13.999999999999574 -3.266664074116683 YTATK(ub)VVYSAPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YTATKVVYSAPR 12 1 O15551 O15551 CLDN3 Claudin-3 1 6615000.0 2386200.0 2914800.0 1314000.0 True False 1984231.026583724 2899097.3938574987 1588751.3247504456 1.0 1.4610684718749267 0.8006886816429936 20.920148579677274 -6.718993943306473 1.7629576959712314 1.2808112045267734 0.8017780688112356 0.5077397481129449 0.19404386031494278 0.35728389683339623 2.1696324131156315 0.0874138286714749 0.21969965160383073 1.909879893665256e-07 6.718993943306473 -0.47903313571553785 YTCHVQHEGLPKPLTLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTCHVQHEGLPKPLTLR 17 1 D9J307;Q2L6G2;D5H3J5;A0A140T9G0;A0A140T9H3;A0A140T9A9;Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913;A0A140T955;A0A140T933;A0A1W2PPQ2;A0A1W2PRT9;A0A140T975;A0A140T941;A0A1W2PQS8;Q9GJ45;A0A1W2PS39;A0A140T9Z6;Q5RJ27;B0UXQ0;Q5SRN5;P04439;P04439-2;A0A1W2PS24;Q5SRN7;Q5SUL5;A0A0G2JIF2;A0A0G2JL56;A0A0G2JI36;A0A1W2PQD0;A0A1W2PSE7;P01889;A0A1W2PPR8 D9J307;Q53Z42;Q5SRN5;P01889 HLA-B;HLA-A HLA class I histocompatibility antigen, A-3 alpha chain;HLA class I histocompatibility antigen, B-7 alpha chain 0 12336300.0 2902500.0 4457700.0 4976100.0 False True 3805205.6078499854 3792628.535978507 4461220.906121712 1.0 0.9966947720655271 1.1723994353730567 21.85954297874589 -6.90261404832886 0.9445938417972187 0.9932095218333676 1.1918538387048556 0.9878225629661829 0.009055438084288624 0.10950661857868908 0.16676641766016057 0.007153094907847337 0.018867505233331795 1.2513706124710736e-07 6.90261404832886 0.19864431687148798 YTCHVQHEGLPKPLTLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTCHVQHEGLPKPLTLR 17 1 D9J307;Q2L6G2;D5H3J5;A0A140T9G0;A0A140T9H3;A0A140T9A9;Q53Z42;A0A140T9I0;A0A140T9X5;A0A140T913;A0A140T955;A0A140T933;A0A1W2PPQ2;A0A1W2PRT9;A0A140T975;A0A140T941;A0A1W2PQS8;Q9GJ45;A0A1W2PS39;A0A140T9Z6;Q5RJ27;B0UXQ0;Q5SRN5;P04439;P04439-2;A0A1W2PS24;Q5SRN7;Q5SUL5;A0A0G2JIF2;A0A0G2JL56;A0A0G2JI36;A0A1W2PQD0;A0A1W2PSE7;P01889;A0A1W2PPR8 D9J307;Q53Z42;Q5SRN5;P01889 HLA-B;HLA-A HLA class I histocompatibility antigen, A-3 alpha chain;HLA class I histocompatibility antigen, B-7 alpha chain 0 8626100.0 2902500.0 2618200.0 3105400.0 False True 3975632.687113204 2502519.266770409 2371968.47772057 1.0 0.6294644057239464 0.5966266665955273 21.92275304026878 -13.999999999999998 0.3430536863620121 5.366349858769143 0.5916637487718732 0.9997412535652492 0.002942115032030284 19.987374977885384 0.18807301829692682 63.38343447098596 0.010036384442411858 1.0000000000000041e-14 13.999999999999998 -4.77468610999727 YTCMFTYASQGGTNEQWQMSLGTSEDHQHFTCTIWRPQGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YTCMFTYASQGGTNEQWQMSLGTSEDHQHFTCTIWRPQGK 40 1 Q969H8;M0QYN0 Q969H8 MYDGF Myeloid-derived growth factor 0 233032000.0 67375000.0 59387000.0 106270000.0 False True 102212800.77228081 48788925.85725123 85265687.92020427 1.0 0.477326963830565 0.8341977450570707 26.607000644750475 -10.12096944165882 5.59327814887653 1.0000041705751244 0.655762354443768 0.5536919436967711 0.14569188635241678 7.577189787997477e-06 1.1909882019270667e-06 0.14106727093677793 0.047021854126676504 7.56886150064428e-11 10.12096944165882 -0.3442418161313564 YTCMFTYASQGGTNEQWQMSLGTSEDHQHFTCTIWRPQGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YTCMFTYASQGGTNEQWQMSLGTSEDHQHFTCTIWRPQGK 40 1 Q969H8;M0QYN0 Q969H8 MYDGF Myeloid-derived growth factor 0 142391000.0 67375000.0 38607000.0 36409000.0 False True 87218265.65980153 36458486.51171946 29782935.587887682 1.0 0.4180143486678272 0.3414758979966107 26.378126966842924 -13.999999999999998 0.28594625002118595 5.9021930472152855 0.3197537368435281 0.9996184001562661 0.005744254243782998 15.729157414743375 0.16949402583349352 45.25085418586256 0.02944603515549785 1.0000000000000041e-14 13.999999999999998 -5.582439310371758 YTCSFCGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTCSFCGK 8 0 C9J4Z3;P61513;M0R0A1;Q6P4E4;E9PEL3;M0R2L6;A6NKH3;G5E9R3 C9J4Z3 RPL37A;RPL37AP8 60S ribosomal protein L37a;Putative 60S ribosomal protein L37a-like protein 0 14068000.0 1370500.0 6680300.0 6017200.0 False True 1796738.7719408784 5683625.279605444 5394597.865058096 1.0 3.163300847271115 3.0024386122812543 20.776949239818734 -10.521533239279657 5.983294652526218 0.9971433727563533 3.082869729776129 0.9955464454851457 0.06567173243480767 0.002502038415394242 0.00020008052743359357 0.06357449527032337 0.021195460503049858 3.009308838785692e-11 10.521533239279657 2.0857263570197757 YTCSFCGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTCSFCGK 8 0 C9J4Z3;P61513;M0R0A1;Q6P4E4;E9PEL3;M0R2L6;A6NKH3;G5E9R3 C9J4Z3 RPL37A;RPL37AP8 60S ribosomal protein L37a;Putative 60S ribosomal protein L37a-like protein 0 13905100.0 1370500.0 7417800.0 5116800.0 False True 1877210.886369902 7090057.06861568 3908317.2238038974 1.0 3.7769102662334513 2.081980906983601 20.840159301341625 -10.177598987967109 6.0766134817137 0.9999805903033374 2.929445586608539 0.6334080220047056 0.6919520133708082 0.00018195567271889215 2.4623145217617937e-05 0.6699863446363362 0.22332655201331267 6.643562301181098e-11 10.177598987967109 1.9294649963052015 YTEGVQSLNWTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTEGVQSLNWTK 12 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 15645900.0 2183300.0 5543100.0 7919500.0 False True 2862327.443107279 4716091.08683457 7100066.109208192 1.0 1.6476420607262483 2.4805219704355412 21.448757291537355 -6.9676885519684815 0.3084417683403273 0.8693038387287344 3.285275454718326 0.9999583265640133 0.003911997360108248 0.07706007114885863 0.011701015600877926 0.013271673396154721 0.07405636002591362 1.0772374620212042e-07 6.9676885519684815 2.4159716159895916 YTEGVQSLNWTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTEGVQSLNWTK 12 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 12630900.0 2183300.0 6366900.0 4080700.0 False True 2990525.011464001 6085589.305477256 3116922.7046545823 1.0 2.0349568327128207 1.04226605452422 21.511967353060246 -6.636340788304909 2.056888096616639 1.6786301834833628 1.046292960519226 0.14104660440972905 0.44322464507226655 0.5426300537938361 4.3827389617461945 0.17572113608528359 0.49104709085693266 2.310251238278321e-07 6.636340788304909 -0.6323372229641369 YTEGVQSLNWTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YTEGVQSLNWTK 12 0 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 0 5150100.0 2593300.0 1519800.0 1037000.0 False True 2156443.852669332 1511612.5357433201 1253831.905453738 1.0 0.700974678228782 0.5814349879324217 21.04022272243343 -13.999999999520064 0.12645307801204503 2.421109525987194 0.4062347455796892 0.9996619557178682 0.003236615385482079 11.943659409657952 0.11021787883480877 4.233160148648644 0.1556354862030014 1.0000000011050936e-14 13.999999999520064 -2.014874780407505 YTEGVQSLNWTK(ub)IMK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTEGVQSLNWTKIMK 15 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 1 13488600.0 4217600.0 5071700.0 4199300.0 True False 5529314.443296493 4315022.129331765 3764796.7185299564 1.0 0.7803900779350892 0.6808794755910901 22.398669187113647 -13.999999999999998 0.10670566144782764 2.0663995250078315 0.48935823003441237 0.9997598090329403 0.0020662031122135743 12.033053584066923 0.09856986911719906 2.782470924880934 0.17028067580576392 1.0000000000000041e-14 13.999999999999998 -1.5770412949734192 YTEGVQSLNWTK(ub)IMK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTEGVQSLNWTKIMK 15 1 Q9Y5B9 Q9Y5B9 SUPT16H FACT complex subunit SPT16 1 17708100.0 4217600.0 6192800.0 7297700.0 True False 5776960.696354391 5919181.619148961 5574133.560849293 1.0 1.0246186412319405 0.9648903383342916 22.46187924863654 -6.794755809168184 1.4770781440051048 1.0136745640529867 0.9641672956744016 0.8164395391943717 0.010500639808269673 0.22832345946202093 0.9838916496346466 0.005594030724664652 0.013054250012165113 1.6041471012258208e-07 6.794755809168184 -0.0495072683785851 YTEVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTEVLK 6 0 P40429;M0QYS1;Q8J015 P40429 RPL13A;RPL13a 60S ribosomal protein L13a 0 7133010.0 2528100.0 869310.0 3735600.0 False True 2447846.849311978 1216430.0163917625 2757134.29440218 1.0 0.4969387756973715 1.1263508152796136 21.22308186728534 -6.69382634253261 1.8526313796401042 0.685755721812441 1.1242934346409994 0.3884873303682155 0.21259637022682462 0.40849046355790175 2.7211330968499663 0.0916976348930386 0.23765827964684494 2.023828267094389e-07 6.69382634253261 0.43853771282855836 YTFAAHMDGTYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTFAAHMDGTYK 12 0 Q15363;E7EQ72 Q15363 TMED2 Transmembrane emp24 domain-containing protein 2 0 8042600.0 3248000.0 2436700.0 2357900.0 False True 4258159.453676743 2073153.858182206 2113927.1265739016 1.0 0.4868661873129537 0.4964415141261593 22.021798544178136 -10.46367467252979 6.08908006892665 1.0002756967688105 0.49165385071955653 0.99973396743976 0.00390911080212416 1.4638349357015003e-05 1.2893400104886982e-06 0.0037869760936257942 0.0012616600862588342 3.4381540157674214e-11 10.46367467252979 -0.508621846049254 YTFNMVTMMK(ub)EK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YTFNMVTMMKEK 12 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2;A0A0C4DG73 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34;Ubiquitin carboxyl-terminal hydrolase 1 37347000.0 6795000.0 10557000.0 19995000.0 True False 10308511.781041162 8673020.867782513 16042979.48588016 1.0 0.8413455843096039 1.5562847311660943 23.297332732990636 -6.848486394207042 1.242335490481574 0.9154310050360764 1.584046827664901 0.9380761372665231 0.07628371320627855 0.15913277869850717 0.47338412885330555 0.04806561566313139 0.11112701629717682 1.4174691179228616e-07 6.848486394207042 0.6686158226288245 YTFNMVTMMK(ub)EK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTFNMVTMMKEK 12 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2;A0A0C4DG73 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34;Ubiquitin carboxyl-terminal hydrolase 1 18645600.0 7778500.0 1992900.0 8874200.0 True False 10654421.656058583 1904847.0883609923 6778296.729885964 1.0 0.1787846539073109 0.6361956517866476 23.344948947000706 -9.288788123111125 13.029705378420974 1.0000070870425553 0.4074897245322598 0.6910968988475934 0.1867372579687642 0.0 0.0 0.180807572537554 0.06026919084585133 5.14294496449531e-10 9.288788123111125 -0.5925173625102955 YTFNMVTMMKEK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTFNMVTMMKEK 12 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2;A0A0C4DG73 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34;Ubiquitin carboxyl-terminal hydrolase 1 6227000.0 2337500.0 2423200.0 1466300.0 True False 3064485.136382199 2061668.0055596202 1314581.3417427854 1.0 0.6727616267682531 0.42897298672974615 21.54721327665532 -7.68571025127473 0.17146188754453848 1.2699809407221776 2.1521066662960008e-14 0.9999556257459833 0.0015584180246603898 0.1336295383685999 0.02061006819346403 0.05226364970357798 0.08368929207023759 2.0620051646996877e-08 7.68571025127473 -1.269980940722156 down YTFNMVTMMKEK(ub) ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTFNMVTMMKEK 12 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2;A0A0C4DG73 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34;Ubiquitin carboxyl-terminal hydrolase 1 5017700.0 1362600.0 1922100.0 1733000.0 True False 1319345.0088495316 2689604.553619082 1279075.3111144041 1.0 2.038590767068893 0.9694775078049959 20.331390448144674 -6.65277983970158 1.9985111966199671 1.6724604920353485 0.9739669535676877 0.20539403793289035 0.44298176953884405 0.5017903133060853 3.8446353910267077 0.17956452416188043 0.4907699405142874 2.224437256251234e-07 6.65277983970158 -0.6984935384676608 YTFNMVTMMKEK(ub) ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YTFNMVTMMKEK 12 1 Q70CQ2-3;Q70CQ2-2;Q70CQ2;A0A0C4DG73 Q70CQ2-3 USP34 Ubiquitin carboxyl-terminal hydrolase 34;Ubiquitin carboxyl-terminal hydrolase 1 62872000.0 27156000.0 24412000.0 11304000.0 True False 35153977.32478772 23053450.740127362 9246787.988834696 1.0 0.6557849920404866 0.2630367512444919 25.06718458941638 -7.354764318771981 0.3402581160960582 1.056620528013118 4.0585883708941394e-11 0.9996885567090024 0.005313407606788154 0.11002679489273873 0.02837604388171923 0.014342619079638198 0.0545964210521042 4.418101421061797e-08 7.354764318771981 -1.056620527972532 down YTIGLGQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTIGLGQAK 9 0 Q01581;D6RIW1 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 0 19228900.0 4591100.0 6057800.0 8580000.0 False True 6018976.560275643 5153999.853119449 7692223.905171585 1.0 0.856291730247811 1.277995324975865 22.52108676778132 -6.814733299399661 1.3943302785727614 0.9221010105690816 1.2862130124632334 0.8718463209553093 0.06266365705458661 0.20043757648236177 0.7670442510623112 0.03532652236358155 0.08156497253223069 1.5320279925187211e-07 6.814733299399661 0.3641120018941518 YTIGLGQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTIGLGQAK 9 0 Q01581;D6RIW1 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 0 7401120.0 2655900.0 899120.0 3846100.0 False True 2571589.908266159 1258143.304848857 2838691.0294732335 1.0 0.48924725548372294 1.103866141466997 21.29422916359095 -6.686065365209207 1.8799964143128332 0.6786304095925939 1.1016719874473995 0.35229649208220293 0.21618588296024782 0.42515753250788024 2.9101271293451245 0.0920914762670978 0.24104428166869749 2.060319793350889e-07 6.686065365209207 0.42304157785480556 YTIGLGQAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTIGLGQAK 9 0 Q01581;D6RIW1 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 0 12590200.0 4591100.0 3278500.0 4720600.0 False True 6288553.739812375 3133645.029450311 3605691.503808757 1.0 0.4983093345631179 0.5733737283632303 22.58429682930421 -10.676626790255503 6.711438172661973 1.0031359344358994 0.5358415314632382 0.980761982824249 0.030644910443602097 0.001444265518873632 6.958810393189086e-05 0.02980219561113624 0.009890602316174057 2.1055870928851786e-11 10.676626790255503 -0.4672944029726612 YTIGLGQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YTIGLGQAK 9 0 Q01581;D6RIW1 Q01581 HMGCS1 Hydroxymethylglutaryl-CoA synthase, cytoplasmic 0 6450300.0 2655900.0 2230800.0 1563600.0 False True 2208498.5263195485 2218782.23762087 1890541.5307304391 1.0 1.0046564266078364 0.8560302432626101 21.074634439025225 -6.899668362774487 0.9633765008729933 1.0062356884786121 0.8405348624309148 0.9864001704627965 0.008045695419225573 0.11164931237946206 0.17880608245223448 0.0062676991623345476 0.016280264229397514 1.259887123253703e-07 6.899668362774487 -0.1657008260476973 YTIHSQLEHLQSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTIHSQLEHLQSK 13 0 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 0 49789800.0 22996300.0 21412900.0 5380600.0 False True 30148371.99648599 18218178.786830455 4823867.126359703 1.0 0.6042839987828834 0.16000423263060307 24.845576763318324 -7.6043406697279305 0.41859460386159303 1.0356539520546337 1.9354733864033733e-24 0.9982833358417692 0.01421627806962789 0.12017328717633347 0.060607611943334236 0.02376577883866062 0.07199953437741652 2.4869057717605642e-08 7.6043406697279305 -1.0356539520546337 down YTIHSQLEHLQSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTIHSQLEHLQSK 13 0 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 0 25512700.0 10517100.0 5289900.0 9705700.0 False True 10183240.41726949 7402184.656464066 7163486.005241244 1.0 0.7268987427529351 0.7034583994592601 23.279693379852937 -13.999999999999998 0.3477255399973001 4.3118014223652015 0.7001217494044205 0.9997503504165485 0.0021268188092978457 20.435335321175764 0.18966294477095774 49.93542989099478 0.007048460446258775 1.0000000000000041e-14 13.999999999999998 -3.611679672960781 YTIHSQLEHLQSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YTIHSQLEHLQSK 13 0 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 0 69204500.0 14951500.0 44454000.0 9799000.0 False True 22682518.601065077 36520836.37931272 7862223.354945723 1.0 1.6100873550081802 0.3466203860878371 24.435077506058185 -6.775374802744116 1.553624176429761 1.347514307321681 0.3379775661931961 0.7507954787005102 0.2575438544500266 0.2578168088127149 1.2287523248262915 0.1306028556578348 0.30941470772155055 1.6773558097207619e-07 6.775374802744116 -1.009536741128485 YTIHSQLEHLQSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTIHSQLEHLQSK 13 0 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 0 39607400.0 22996300.0 11583800.0 5027300.0 False True 31498653.56164043 11071989.41349595 3839955.2804935304 1.0 0.3515067522435181 0.12190855310621562 24.908786824841215 -10.203704184834505 0.24700783920944772 1.6351780145742123 1.0466474483190276e-16 0.9991103826512736 0.011090304098234778 1.747037070849773 0.117856668949877 0.8335916207974251 0.10394540795792363 6.255986677052663e-11 10.203704184834505 -1.6351780145742123 YTIHSQLEHLQSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YTIHSQLEHLQSK 13 0 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 0 32803500.0 10517100.0 13447200.0 8839200.0 False True 8745434.636528235 13374757.264539784 10687435.85215687 1.0 1.529341630280516 1.2220588565738308 23.060098655287213 -10.214047744825764 4.927367426099597 0.9999496330275461 1.3757002434276933 0.6659065163863247 0.12544766705663798 6.942305498651738e-05 1.1073479434975367e-05 0.1214804235190436 0.04048806044397456 6.108748637547432e-11 10.214047744825764 0.3757506104001471 YTIHSQLEHLQSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YTIHSQLEHLQSK 13 0 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 0 49131500.0 14951500.0 23659000.0 10521000.0 False True 19355011.48812653 22342355.85206755 8606285.954576254 1.0 1.154344747652236 0.44465413827606565 24.206203828150635 -6.8497514862354425 1.2363359313040343 1.0823449370649483 0.4164264642519528 0.9399365071005028 0.07468942973576129 0.15773117311095422 0.4640830493170652 0.04727607534219951 0.10937936761049734 1.4133460639384093e-07 6.8497514862354425 -0.6659184728129954 down YTIHSQLEHLQSK(ub)YIGTGHADTTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTIHSQLEHLQSKYIGTGHADTTK 24 1 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 1 36160800.0 13271700.0 18104000.0 4785100.0 True False 17399327.22332562 15402953.768839302 4289983.753920346 1.0 0.8852614570171442 0.24656032379051834 24.052528186932854 -6.937442696313689 0.6829462223428953 1.0075849482581558 0.08655509666935488 0.9978092939579029 0.015513850370624426 0.08895312124062014 0.06007062657505048 0.014823491045352334 0.05561948987629223 1.1549343643148658e-07 6.937442696313689 -0.9210298515888009 down YTIHSQLEHLQSK(ub)YIGTGHADTTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTIHSQLEHLQSKYIGTGHADTTK 24 1 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 1 47205100.0 19172100.0 21048000.0 6985000.0 True False 18563492.179776963 29452576.163869955 5155418.954491709 1.0 1.5865859655413082 0.27771816340182015 24.145964801213974 -6.7848588694234815 1.5167468897766363 1.3300426077488308 0.26568906499038847 0.7842706414142016 0.2486287726424444 0.24309507364859928 1.10480928575638 0.12906617669706733 0.3033538772579871 1.6411229943548572e-07 6.7848588694234815 -1.0643535427584423 down YTIHSQLEHLQSK(ub)YIGTGHADTTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTIHSQLEHLQSKYIGTGHADTTK 24 1 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 1 43546100.0 13271700.0 22191800.0 8082600.0 True False 18178606.144206814 21211292.897530984 6173656.346372218 1.0 1.1668272434787654 0.3396110954491221 24.115738248455745 -6.854221105593026 1.2144951398229296 1.0894599413080424 0.3037385191626667 0.9462333514377991 0.08282280505148051 0.15287278144845778 0.43178886054868737 0.053298208151719394 0.12371950825848699 1.3988749538071866e-07 6.854221105593026 -0.7857214221453757 down YTIHSQLEHLQSK(ub)YIGTGHADTTK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YTIHSQLEHLQSKYIGTGHADTTK 24 1 Q9BWJ5 Q9BWJ5 SF3B5 Splicing factor 3B subunit 5 1 44557300.0 19172100.0 19828800.0 5556400.0 True False 15942450.618039468 19721978.31869138 6718217.550109109 1.0 1.2370731947806843 0.42140431926489386 23.92637007664825 -6.828921538988727 1.332713743984576 1.1267668080096969 0.39992870348678305 0.9037283282975594 0.10629677143973106 0.18212370020494897 0.6330105393662856 0.06263227786704804 0.14414251731315522 1.4827859457360111e-07 6.828921538988727 -0.7268381045229138 down YTILIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTILIK 6 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 8461300.0 1980800.0 2886800.0 3593700.0 False True 2596847.982094489 2456100.6926582647 3221858.3972045616 1.0 0.9458007205632789 1.2406804015558779 21.308330131319863 -6.859268333970064 1.1894273934452395 0.9706484663739025 1.2547612901671725 0.952741018780877 0.027860282816568133 0.14756230630867764 0.3971040069116857 0.018274207987379398 0.04262293227525238 1.3827117901953276e-07 6.859268333970064 0.2841128237932701 YTILIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTILIK 6 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 9991500.0 1650400.0 1040000.0 7301100.0 False True 1598008.955383286 1455277.4235283528 5388722.881694975 1.0 0.9106816445714481 3.3721481118999597 20.607844062603114 -6.8984804449452355 0.9708380034508045 0.8933507275209895 3.622680998605602 0.9857946248324487 0.13585775855753493 0.11253198342236234 0.18380123005057936 0.10524894623407326 0.271806625546869 1.2633379870706047e-07 6.8984804449452355 2.7293302710846126 up YTILIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTILIK 6 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 7173100.0 1980800.0 2124300.0 3068000.0 False True 2713155.2891072654 2030441.4018792983 2343401.5874433946 1.0 0.7483690336602123 0.8637181944032646 21.371540192842755 -10.138110320559113 4.981563536746384 1.0000098661081585 0.8060436140312283 0.7903474923825202 0.04709109768156058 5.16029477153651e-06 8.928240832029502e-07 0.04559807800173025 0.015198586422689734 7.275949555886074e-11 10.138110320559113 -0.1939662520769302 YTILIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YTILIK 6 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 5603300.0 1650400.0 2742100.0 1210800.0 False True 1372380.725116828 2727327.7630357626 1463972.681893332 1.0 1.9872967560103196 1.0667394660244203 20.38824933803739 -6.62958061737212 2.0815302773632234 1.6506235588287452 1.0704008713297428 0.11615781390808655 0.4235375968836476 0.5600785620958104 4.6237417197063975 0.1664331714484822 0.4693207318747129 2.3464936464906954e-07 6.62958061737212 -0.5802226874990024 YTISQEAYDQR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTISQEAYDQR 11 0 Q99426;K7EP07;A0A494C0X0;Q99426-2;K7EK42 Q99426 TBCB Tubulin-folding cofactor B 0 3936980.0 690380.0 1454300.0 1792300.0 False True 945632.142817988 1390044.2172730155 1368995.6535771799 1.0 1.46996295317403 1.44770423041836 19.85091954918236 -10.085819926427307 5.409400780331096 0.9999947941987133 1.458833591796473 0.9982380822056567 0.009087085513887512 5.705121658045768e-07 9.6417495809587e-08 0.008798632582502457 0.0029328442382628083 8.206917610940545e-11 10.085819926427307 0.4588387975977597 YTISSALNLMQICK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTISSALNLMQICK 14 0 P78346;P78346-2;Q5VU10;Q5VU11 P78346 RPP30 Ribonuclease P protein subunit p30 0 10756000.0 2258300.0 6372200.0 2125500.0 False True 2960653.1694083055 5421492.598641058 1905573.6492356884 1.0 1.8311812591424068 0.6436328540355581 21.497484062851495 -6.718550362032536 1.7643358899280692 1.506470350354849 0.6456140918545568 0.5056713099370016 0.3498299744950317 0.35818516167377773 2.178219332269309 0.15747673049768465 0.39603033844200036 1.9118316102778342e-07 6.718550362032536 -0.8608562585002923 YTISSALNLMQICK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTISSALNLMQICK 14 0 P78346;P78346-2;Q5VU10;Q5VU11 P78346 RPP30 Ribonuclease P protein subunit p30 0 10904400.0 5371000.0 3069800.0 2463600.0 False True 5200500.544936759 4295587.148795515 1818309.2535842187 1.0 0.8259949425402381 0.3496412004714693 22.310219057759525 -6.953488333946883 0.519136498727314 1.0081488434432826 0.14626056633378307 0.9994473693836803 0.006462502108215571 0.08211450336232548 0.030393755360190806 0.007331291874265458 0.039343782180881214 1.1130422910312925e-07 6.953488333946883 -0.8618882771094996 down YTISSALNLMQICK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YTISSALNLMQICK 14 0 P78346;P78346-2;Q5VU10;Q5VU11 P78346 RPP30 Ribonuclease P protein subunit p30 0 22827700.0 3703900.0 10015000.0 9108800.0 False True 5619087.091361061 8227745.002447855 7308441.687471139 1.0 1.4642494178631644 1.3006457398938234 22.4219043304202 -10.042068150846543 5.914671065682272 0.9999991745129355 1.3824475788785306 0.8793162834777879 0.06679092184471429 7.270124831919257e-07 1.1779660276018326e-07 0.06467017171797158 0.021556677331849225 9.076780833220672e-11 10.042068150846543 0.38244840436559513 YTISSALNLMQICK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTISSALNLMQICK 14 0 P78346;P78346-2;Q5VU10;Q5VU11 P78346 RPP30 Ribonuclease P protein subunit p30 0 23665000.0 2258300.0 5948700.0 15458000.0 False True 3093254.538262785 5685866.764279713 11807138.76750324 1.0 1.8381503021969137 3.8170601938676194 21.560694124374386 -6.956675771700908 0.48000271058101734 0.9525017634706423 4.785213967816606 0.9996263213768514 0.022831055250223668 0.08091080705696065 0.02568745101912692 0.02790220024186088 0.16324309577487492 1.1049031921822141e-07 6.956675771700908 3.832712204345964 YTISSALNLMQICK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YTISSALNLMQICK 14 0 P78346;P78346-2;Q5VU10;Q5VU11 P78346 RPP30 Ribonuclease P protein subunit p30 0 21491000.0 3703900.0 12033000.0 5754100.0 False True 4794771.564784258 11363352.972142896 4706912.842051817 1.0 2.369946684343072 0.9816761400318361 22.19303065251265 -6.64918686957884 2.0111746243653394 1.889509031275682 0.9874731927382869 0.19089781741451417 0.5848205834728181 0.510497921413646 3.956877068800272 0.23589035237961772 0.647844704729652 2.2429166269881658e-07 6.64918686957884 -0.902035838537395 YTIVVSATASDAAPLQYLAPYSGCSMGEYFR ddPTM_RPMI8226_Bortezomib_8h_R1 2 YTIVVSATASDAAPLQYLAPYSGCSMGEYFR 31 0 P25705;P25705-2;P25705-3 P25705 ATP5A1 ATP synthase subunit alpha, mitochondrial 0 111044200.0 28881400.0 33304800.0 48858000.0 False True 43815195.31316596 27361298.22840987 39201194.884777844 1.0 0.6244705297522231 0.8946940577256387 25.38492795415554 -9.96334665508255 6.172838972484136 1.000000095911853 0.7595822937389101 0.5134814267252539 0.11031829333833536 1.456146451969088e-07 2.4495836711052452e-08 0.10681526960356998 0.03560507607343885 1.0880612530576861e-10 9.96334665508255 -0.24041780217294284 YTK(ub)EYTEYNEEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YTKEYTEYNEEK 12 1 C9JK83;O95630-2;O95630;F5H5B9;C9JZ93;C9JEK5 C9JK83 STAMBP STAM-binding protein 1 2809550.0 686090.0 1271600.0 851860.0 True False 570514.2339405017 1264749.6384071629 1029979.9874443782 1.0 2.2168590425371617 1.805353707532201 19.121903355655768 -10.061330794019197 4.591176551897646 0.9999509966406008 2.01110637507845 0.8894995061771565 0.16799634967469382 58246128.500065915 3.5917168269895394 30521.59189429048 0.05750961891333686 8.68298810312982e-11 10.061330794019197 1.011155378437849 YTK(ub)PNGDKELSEAEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YTKPNGDKELSEAEK 15 2 O60502-2;O60502-4;O60502 O60502-2 MGEA5 Protein O-GlcNAcase 1 11198760.0 470760.0 1758900.0 8969100.0 True False 609408.1000669124 1661015.6688026376 7336815.830737559 1.0 2.7256212521957943 12.039248953093969 19.21704915045186 -6.938115379799162 0.6768718624981451 0.891266168715854 14.417432140728714 0.9979064590221053 0.22185202703174509 0.08863704928625726 0.05860499900772867 0.21298878744562444 0.808487410904989 1.1531468585140628e-07 6.938115379799162 13.52616597201286 YTLHVVDSPTVK(ub)PSR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTLHVVDSPTVKPSR 15 1 Q8N6R0;Q8N6R0-3;Q8N6R0-4 Q8N6R0 METTL13 Methyltransferase-like protein 13 1 12208860.0 810760.0 1227200.0 10170900.0 True False 785022.8675875857 1717227.3597634549 7506836.1695404025 1.0 2.1874870537728155 9.562570059403853 19.582375154523486 -6.935109013431538 0.7035927063401507 0.9062270305540353 11.29448221397351 0.9974505142677104 0.19124984498915032 0.09007046025484079 0.06531145276334203 0.1798760664904417 0.6495984746992276 1.1611571120719423e-07 6.935109013431538 10.388255183419474 YTLHVVDSPTVK(ub)PSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YTLHVVDSPTVKPSR 15 1 Q8N6R0;Q8N6R0-3;Q8N6R0-4 Q8N6R0 METTL13 Methyltransferase-like protein 13 1 112044400.0 2273900.0 17907500.0 91863000.0 True False 3449672.5443575475 14711766.713063894 73706237.78501678 1.0 4.264684987891728 21.366154855936774 21.718027991779437 -6.938772139586606 0.6708902734172892 0.8033576546147475 25.81591907613406 0.9979985937905799 0.3995562708649547 0.08833134375576596 0.05719446567640637 0.3854103126127515 1.4800304306376657 1.1514043354945907e-07 6.938772139586606 25.01256142151931 YTLHVVDSPTVK(ub)PSR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YTLHVVDSPTVKPSR 15 1 Q8N6R0;Q8N6R0-3;Q8N6R0-4 Q8N6R0 METTL13 Methyltransferase-like protein 13 1 12702160.0 810760.0 2183700.0 9707700.0 True False 674182.8627579485 2171935.9746694863 11737535.186666597 1.0 3.221582888927978 17.410017125992592 19.362780429957763 -6.934527929209778 0.7086386847007201 0.8161811779032815 20.689850270564982 0.9973557426723207 0.3737852791578431 0.09035391609915641 0.06665543628227252 0.35022591213492255 1.253388275009485 1.1627117753231681e-07 6.934527929209778 19.8736690926617 YTLHVVDSPTVK(ub)PSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YTLHVVDSPTVKPSR 15 1 Q8N6R0;Q8N6R0-3;Q8N6R0-4 Q8N6R0 METTL13 Methyltransferase-like protein 13 1 81821700.0 2273900.0 13504800.0 66043000.0 True False 2943608.375270101 12753246.008326713 54023851.658404954 1.0 4.332521308020975 18.35293448417635 21.489154313871886 -6.943716015336847 0.6240347539303596 0.8468879373516024 22.586503969913625 0.9986112455055567 0.280198558669099 0.0861115001103243 0.04719141779109678 0.2811515437012566 1.1883828777985834 1.138371422268121e-07 6.943716015336847 21.739616032562022 YTLHYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTLHYK 6 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 11566300.0 2437900.0 3758400.0 5370000.0 False True 3196110.5086571868 3197661.3701284537 4814363.912677322 1.0 1.0004852339952157 1.5063196030415191 21.607885861049212 -6.907105734184129 0.9152196664082262 0.9828687692599143 1.5677991960231374 0.9897826362225294 0.02411459079774261 0.1063634212962097 0.14937996362913425 0.01946461352703026 0.05271232966203399 1.2384950234011484e-07 6.907105734184129 0.5849304267632232 YTLHYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTLHYK 6 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 11040600.0 2981900.0 1348600.0 6710100.0 False True 2887241.216709535 1887103.0128560928 4952523.5113149285 1.0 0.6536007459074524 1.715313387275313 21.461260212960823 -6.818833899136202 1.376889088542093 0.813068439167356 1.7379210424730689 0.8816826128375259 0.1520629924902011 0.19500321417207916 0.726734503785863 0.08679265093848702 0.20011022457530694 1.5176306915943658e-07 6.818833899136202 0.9248526033057128 YTLHYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YTLHYK 6 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 15353800.0 1742700.0 12128000.0 1483100.0 False True 2643803.308435682 9963663.643503489 1189964.6349341772 1.0 3.7686856702660347 0.4500957507456445 21.334183417690255 -6.685343347801524 1.8831778957548062 2.743349280645285 0.4622392075002252 0.3485989660712192 1.1720958555501337 0.4267718859634352 2.930644595788004 0.49862678712446823 1.3060286701271708 2.0637479373064782e-07 6.685343347801524 -2.2811100731450598 YTLHYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTLHYK 6 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 11768200.0 2437900.0 2990800.0 6339500.0 False True 3339257.5117702964 2858656.566746982 4842240.666100843 1.0 0.8560755068067435 1.450095013347367 21.671095922572103 -6.842692331064304 1.2698363934718704 0.9234432871595996 1.470697553405833 0.9289887194602043 0.0674238540919275 0.16567334338452175 0.5177657789972401 0.041615203676641496 0.09595369698674303 1.4365067430441748e-07 6.842692331064304 0.5472542662462335 YTLHYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YTLHYK 6 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 7642600.0 2981900.0 3012600.0 1648100.0 False True 2479581.9705682658 2996370.525845717 1992710.0900465806 1.0 1.208417612892634 0.8036475961268161 21.2416654883951 -6.766725189409628 1.5867736773076007 1.1200394139960503 0.8016352488287022 0.7179780459950684 0.08776845816816084 0.2717469393927638 1.3497719521988194 0.04361025575882884 0.10413458773942658 1.711097712056547e-07 6.766725189409628 -0.31840416516734815 YTLHYK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YTLHYK 6 0 Q12931-2;Q12931;I3L0K7;I3L239 Q12931-2 TRAP1 Heat shock protein 75 kDa, mitochondrial 0 6692200.0 1742700.0 1760700.0 3188800.0 False True 2255959.5037526735 1662715.4972203092 2608471.119851035 1.0 0.7370325107584896 1.1562579538825837 21.105309739782705 -6.737140743482536 1.697346638508708 0.8430191228802182 1.1563454129886255 0.5919815888684898 0.11049729706589809 0.32300330820922285 1.8260710381451684 0.05152647333006419 0.12683146530444908 1.8317207133993985e-07 6.737140743482536 0.3133262901084073 YTPAYAHLVTPAEEGAGGAGLGPSK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTPAYAHLVTPAEEGAGGAGLGPSKR 26 1 B4E0T2;P50542-3;P50542;P50542-4;P50542-2 B4E0T2 PEX5 Peroxisomal targeting signal 1 receptor 1 8573500.0 1499900.0 3075100.0 3998500.0 True False 1966383.4250522596 2616307.0666459175 3584773.5763203437 1.0 1.3305172497456264 1.823028779966996 20.907113229500677 -6.965367098987925 0.3517007454032989 0.9533264337760309 2.2168820359194354 0.9999205074436573 0.0030150050100789497 0.07783666615605596 0.01442232196847264 0.006731812523912557 0.042285379699176326 1.0830110830224292e-07 6.965367098987925 1.2635556021434047 YTPAYAHLVTPAEEGAGGAGLGPSK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTPAYAHLVTPAEEGAGGAGLGPSKR 26 1 B4E0T2;P50542-3;P50542;P50542-4;P50542-2 B4E0T2 PEX5 Peroxisomal targeting signal 1 receptor 1 15327000.0 2456200.0 3898900.0 8971900.0 True False 2378229.275455908 5455751.102494897 6621890.238769385 1.0 2.294039165525379 2.7843784058624728 21.181456375500428 -9.785568439711604 0.25544975260701336 6.950186525549929e-16 3.055931557275525 0.9990560076024327 0.023126210466185855 1.2024502798336607 0.11002586086515623 1.1204722110872638 0.21198441244342667 1.6384438414253606e-10 9.785568439711604 3.055931557275524 YTPAYAHLVTPAEEGAGGAGLGPSK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YTPAYAHLVTPAEEGAGGAGLGPSKR 26 1 B4E0T2;P50542-3;P50542;P50542-4;P50542-2 B4E0T2 PEX5 Peroxisomal targeting signal 1 receptor 1 12942400.0 2456200.0 5079700.0 5406500.0 True False 2042439.1281095222 5052334.6478585 6536974.1531684 1.0 2.4736769768678153 3.200572327077875 20.961861650934704 -9.153758361511777 0.2355830693155584 1.0423523867792155e-22 3.746494442445006 0.9992576205649693 0.024943235816445974 0.5927135858082789 0.08413658023452163 0.8009284717261572 0.3321394133161319 7.018456919607824e-10 9.153758361511777 3.746494442445006 YTPSGQAGAAASESLFVSNHAY ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTPSGQAGAAASESLFVSNHAY 22 0 P04075;J3KPS3;P04075-2;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 55943000.0 10354000.0 24008000.0 21581000.0 False True 13574194.268278642 20426099.98245101 19348005.139569696 1.0 1.5047743960895343 1.4253520140627276 23.694363229853888 -10.663053251071279 6.487363921608148 0.9969687915940301 1.4650632050761307 0.9785944745898786 0.032424051687011686 0.001427853946489123 7.416114863128131e-05 0.03153432426914267 0.010464817683363735 2.172434789173681e-11 10.663053251071279 0.4680944134821007 YTPSGQAGAAASESLFVSNHAY ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTPSGQAGAAASESLFVSNHAY 22 0 P04075;J3KPS3;P04075-2;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 102561000.0 27627000.0 15551000.0 59383000.0 False True 26749996.007255226 21760595.39739367 43828810.848186255 1.0 0.8134803231930086 1.6384604631828301 24.673035340386498 -6.8473244914501 1.2481367376132568 0.9006572049433268 1.6697390652200326 0.9362888352760739 0.08916183985265903 0.1604292708628671 0.4823199799778858 0.05593847874437329 0.1292274160201309 1.421266463812261e-07 6.8473244914501 0.7690818602767058 YTPSGQAGAAASESLFVSNHAY ddPTM_RPMI8226_Bortezomib_8h_R1 1 YTPSGQAGAAASESLFVSNHAY 22 0 P04075;J3KPS3;P04075-2;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 242432600.0 16799000.0 225633600.0 0.0 False True 25485311.171406988 185367521.19663674 0.0 1.0 7.273504331569949 0.0 24.603162632628656 -6.678521891244153 1.9073465129473368 4.974578514831913 0.02811739780528733 0.3173215527366434 2.659721890007634 0.44179170822244135 3.10617632123036 1.1195158012434885 2.9580262708731717 2.0964191045786936e-07 6.678521891244153 -4.946461117026626 YTPSGQAGAAASESLFVSNHAY ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTPSGQAGAAASESLFVSNHAY 22 0 P04075;J3KPS3;P04075-2;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 63973000.0 10354000.0 20750000.0 32869000.0 False True 14182153.606329069 19833196.388925977 25106019.158304065 1.0 1.398461541135404 1.7702543531258894 23.75757329137678 -6.971959429732891 0.20607801051590938 0.7953355150563141 2.383714133981675 0.9999939013569595 0.0007766939062602518 0.07567185509153006 0.006704553636172924 0.011488163025509392 0.03888412415092629 1.066695763552611e-07 6.971959429732891 1.5883786189253608 YTPSGQAGAAASESLFVSNHAY ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YTPSGQAGAAASESLFVSNHAY 22 0 P04075;J3KPS3;P04075-2;H3BR68 P04075 ALDOA Fructose-bisphosphate aldolase A;Fructose-bisphosphate aldolase 0 48663200.0 27627000.0 11625000.0 9411200.0 False True 22973074.583617665 11562373.817618161 11379038.40752769 1.0 0.5033011047578023 0.495320657498853 24.453440615820774 YTPSQQGVAFNSGAK(ub)QR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTPSQQGVAFNSGAKQR 17 1 G3V4X8;G3V3A4;Q13573 G3V4X8 SNW1 SNW domain-containing protein 1 1 4212200.0 1339700.0 1452100.0 1420400.0 True False 1297171.9568147059 2031931.1026014613 1048354.6289133892 1.0 1.5664315682486742 0.8081847772038607 20.30693830936091 -6.70674272169332 1.8069231028041675 1.3493827967479497 0.8101391563300882 0.4495904379091131 0.23881623483214276 0.3816504606563805 2.4269535681032255 0.10526221771889346 0.26846636225726805 1.964523726243881e-07 6.70674272169332 -0.5392436404178615 YTPVQQGPVGVNVTYGGDPIPK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTPVQQGPVGVNVTYGGDPIPK 22 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 15252500.0 3410300.0 6229300.0 5612900.0 False True 4470936.325392179 5299912.721621222 5032130.950738643 1.0 1.1854144939441353 1.1255206034045313 22.092145568639065 -10.083189362259802 4.295072424492589 0.9999830926672594 1.1554675486319965 0.8998363024609843 0.024451578500959928 16992082.594766527 0.2621845065291435 3015.1074141880026 0.00837042568300588 8.25677856776419e-11 10.083189362259802 0.15548445596473714 YTPVQQGPVGVNVTYGGDPIPK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTPVQQGPVGVNVTYGGDPIPK 22 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 11787000.0 3780000.0 2736400.0 5270600.0 False True 3660005.969067391 3829058.790137488 3890071.7453892594 1.0 1.0461892200446803 1.0628593992103492 21.803414570712427 -13.999999766357957 0.1418271012599794 0.7789798743898139 1.0830424649001853 0.9995957040619333 0.0005345913120062103 11.936104395341234 0.1181201791332245 0.7293921585333388 0.018066153174569576 1.0000005379808292e-14 13.999999766357957 0.30406259051037143 YTPVQQGPVGVNVTYGGDPIPK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTPVQQGPVGVNVTYGGDPIPK 22 0 P21333-2;P21333;Q60FE5;A0A087WWY3 P21333-2 FLNA Filamin-A 0 12815300.0 3410300.0 4969400.0 4435600.0 False True 4671180.069892216 4749835.476391752 3388002.634049518 1.0 1.0168384445306455 0.7252990857463762 22.155355630161957 -6.893200859686221 1.0032289947737096 1.0144839740147689 0.698590646564197 0.9828700704677169 0.01749111833370456 0.11658551844640899 0.2069723898349548 0.013225151842641922 0.033374935607025515 1.2787897315682014e-07 6.893200859686221 -0.31589332745057186 YTQQIIQGIQQLVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTQQIIQGIQQLVK 14 0 Q8TCS8 Q8TCS8 PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial 0 12516800.0 3831600.0 1210200.0 7475000.0 False True 5023264.705267183 1029642.8773226534 6701558.705263114 1.0 0.2049748396183489 1.3341042326987353 22.260193870396847 -6.717507145941738 1.768232448695512 0.5150203406915055 1.332103347086169 0.5006674742932249 0.3346581233086134 0.36022688820991994 2.1997731398148948 0.15035365767792871 0.37856263259933937 1.916429529278251e-07 6.717507145941738 0.8170830063946635 YTQQIIQGIQQLVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTQQIIQGIQQLVK 14 0 Q8TCS8 Q8TCS8 PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial 0 65640000.0 35244000.0 10687000.0 19709000.0 False True 34125198.51159023 14954374.831968749 14546621.642673874 1.0 0.4382208890855146 0.4262721471857016 25.02433410265 YTQQIIQGIQQLVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTQQIIQGIQQLVK 14 0 Q8TCS8 Q8TCS8 PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial 0 35807100.0 3831600.0 5637500.0 26338000.0 False True 5248246.065096622 5388416.6092805015 20117506.84813691 1.0 1.0267080739822931 3.8331866681953177 22.32340393191974 -6.908981288433856 0.9026280938929928 0.9102811986625656 4.18810290742868 0.9905317990040767 0.12934969786076406 0.10509597611323537 0.142443755861298 0.10536975500321802 0.28886147355908887 1.233157962662219e-07 6.908981288433856 3.2778217087661146 up YTQQIIQGIQQLVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YTQQIIQGIQQLVK 14 0 Q8TCS8 Q8TCS8 PNPT1 Polyribonucleotide nucleotidyltransferase 1, mitochondrial 0 56564000.0 35244000.0 10089000.0 11231000.0 False True 29306947.57393206 10034648.554490287 13579350.173723169 1.0 0.34239828386003274 0.46334918160503785 24.804739378084275 -9.958956060508696 6.186419873467739 1.0000002166363093 0.4028737327355278 0.970147221808757 0.04937799723465323 1.4757913474753872e-07 2.4759314425774304e-08 0.047810058049802796 0.015936680079880083 1.0991170363333891e-10 9.958956060508696 -0.5971264839007815 YTQSNSVCYAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTQSNSVCYAK 11 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 13236700.0 1760400.0 7057100.0 4419200.0 False True 2307901.447737853 6004208.188360349 3961943.5759597025 1.0 2.6015877732758144 1.7166866374831993 21.138150188500145 -10.127285379364531 4.924759898414099 0.9999416252939197 2.1591372053840763 0.6958456687442436 0.3612593759326678 0.00023155373813214342 4.103416124094259e-05 0.34980534689181797 0.11659596221845349 7.45958420385145e-11 10.127285379364531 1.1591955800901566 YTQSNSVCYAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTQSNSVCYAK 11 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 9315000.0 1760400.0 3373300.0 4181300.0 False True 2411267.453021219 3224256.451988629 3193763.056576616 1.0 1.337162515070142 1.3245163047238755 21.201360250023036 -10.095586602273647 4.641434613190724 0.9999790656232604 1.3308394099038936 0.9989053570599309 0.005162793780135874 626791.3642866916 1363334.2310341261 80.98152995320014 0.0017673616701300713 8.024415307705085e-11 10.095586602273647 0.33086034428063316 YTQSNSVCYAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YTQSNSVCYAK 11 0 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 0 4588700.0 1360800.0 1661900.0 1566000.0 False True 1761582.425378229 1569413.8040724916 1281004.0685169098 1.0 0.8909113655215555 0.7271894008830531 20.748440550204357 -6.965248678995141 0.3537671362095709 1.0151515121621282 0.5973926512906798 0.9999181677785737 0.0010142017963572563 0.07787676481958193 0.014563550853921144 0.0022267293060455958 0.01403788747010138 1.0833064302043354e-07 6.965248678995141 -0.4177588608714484 YTQSNSVCYAK(ub)NGQVIGIGAGQQSR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YTQSNSVCYAKNGQVIGIGAGQQSR 25 1 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 1 32049100.0 6975600.0 6702500.0 18371000.0 True False 10582495.184669718 5506386.5081284745 14739963.797704656 1.0 0.5203296965450337 1.3928627927993424 23.335176496401562 -6.757476720756538 1.622127922014809 0.7204992307994591 1.3956389345942832 0.6804790856751151 0.20168388404003032 0.28719864548312457 1.4888530468163332 0.09813030335225073 0.2363989214234628 1.7479269530550027e-07 6.757476720756538 0.6751397037948241 YTQSNSVCYAK(ub)NGQVIGIGAGQQSR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YTQSNSVCYAKNGQVIGIGAGQQSR 25 1 P31939-2;P31939;H7C1S2 P31939-2 ATIC Bifunctional purine biosynthesis protein PURH;Phosphoribosylaminoimidazolecarboxamide formyltransferase;IMP cyclohydrolase 1 27237400.0 6975600.0 7414800.0 12847000.0 True False 9030051.709632827 7002159.861866966 10508977.821351672 1.0 0.7754285453755926 1.1637782550172107 23.10630281849401 -6.749921923440311 1.6502418379284192 0.8679371810034959 1.164540615439407 0.6486008330065467 0.09436572626580886 0.30017644797943077 1.6083679865833214 0.045173686086344006 0.1096738271960043 1.778599134155605e-07 6.749921923440311 0.296603434435911 YTRPTPVQK(ub)HAIPIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTRPTPVQKHAIPIIK 16 2 A0A2R8YCW1;A0A0D9SF53;A0A2R8YFR4;A0A0D9SFB3;A0A2R8YF78;A0A0D9SG12;A0A2U3TZJ9;A0A2R8Y5G6;O00571-2;A0A2R8YFS5;O00571;A0A2R8Y4A4;A0A2R8Y645;A0A2R8Y7T2;A0A2R8YDT5;F6S8Q4;A0A2R8YDH3;O15523-3;C9J081;C9J8G5;A0A2R8Y4D2;O15523-2;O15523 A0A2R8YCW1;O15523-2 DDX3X;DDX3Y ATP-dependent RNA helicase DDX3X;ATP-dependent RNA helicase DDX3Y 1 9295700.0 2146100.0 3563300.0 3586300.0 True False 2077973.230215745 4986144.272364015 2646940.4433061695 1.0 2.3995228619217244 1.2738087309389214 20.98674563796295 -6.591911908529576 2.2208216294986785 1.9460513333151437 1.2770952014289247 0.0 0.6061552748594307 0.663984874501133 6.17625496077577 0.2275612321783696 0.6756072064112367 2.559104918260457e-07 6.591911908529576 -0.6689561318862189 YTVNFLEAK(ub)EGDLHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTVNFLEAKEGDLHR 15 1 Q86X55-1;Q86X55 Q86X55-1 CARM1 Histone-arginine methyltransferase CARM1 1 6532800.0 1941600.0 2601700.0 1989500.0 True False 2545456.402481144 2213536.501347167 1783645.624631567 1.0 0.8696029911137181 0.700717412756701 21.27949292525673 -6.967582474081177 0.3105571632991169 1.0258476345336212 0.5391001053017989 0.9999569072042039 0.0008042494853171701 0.07709527910877542 0.01182428632844326 0.0026654084229814946 0.014985739477814813 1.0775006130294297e-07 6.967582474081177 -0.4867475292318223 YTVNFLEAK(ub)EGDLHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTVNFLEAKEGDLHR 15 1 Q86X55-1;Q86X55 Q86X55-1 CARM1 Histone-arginine methyltransferase CARM1 1 10123800.0 3922200.0 4045300.0 2156300.0 True False 3797691.9079037323 5660609.385960817 1591500.3423866099 1.0 1.4905393916183651 0.41907041987118265 21.856691439274847 -6.782197699330958 1.5271372405679047 1.2769511262022393 0.40996039550839747 0.775189641227171 0.20764747407574716 0.24714910599015447 1.1385740954496153 0.10707638655972772 0.2522132978178773 1.651209964089528e-07 6.782197699330958 -0.8669907306938418 down YTVNFLEAK(ub)EGDLHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTVNFLEAKEGDLHR 15 1 Q86X55-1;Q86X55 Q86X55-1 CARM1 Histone-arginine methyltransferase CARM1 1 6994400.0 1941600.0 3088300.0 1964500.0 True False 2659461.989767092 2951848.694357596 1500525.560147504 1.0 1.1099420505784745 0.5642214725839777 21.34270298677962 -6.854286142799776 1.2142423655263275 1.058958426084211 0.5405346474266814 0.9463150506088662 0.05460138176456907 0.15280094889672713 0.4313821902254228 0.035144715170033626 0.08158131699376589 1.3986654827880885e-07 6.854286142799776 -0.5184237786575296 YTVNFLEAK(ub)EGDLHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YTVNFLEAKEGDLHR 15 1 Q86X55-1;Q86X55 Q86X55-1 CARM1 Histone-arginine methyltransferase CARM1 1 10914400.0 3922200.0 3560400.0 3431800.0 True False 3261483.0829212423 3541219.418515932 4149373.5131496065 1.0 1.085769672410545 1.2722351787988118 21.637096714709124 -6.958380964515063 0.4576835779082323 0.9944373032292293 1.371055165257289 0.9997053466382073 0.0019507708691446936 0.08028466790938897 0.023307453741090896 0.00252259565833768 0.015407977363510702 1.1005734594048155e-07 6.958380964515063 0.3766178620280598 YTVQDESHSEWVSCVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTVQDESHSEWVSCVR 16 0 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RBD0;D6RFZ9 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 82247100.0 7140100.0 40630000.0 34477000.0 False True 9360740.244826755 34568162.37449957 30909650.766736653 1.0 3.692887685202437 3.302051970069245 23.158191191580823 -10.03197773689177 6.313998156899123 0.9999980711806208 3.497469827635883 0.9819638128174358 0.15955801255549776 4.333436593421465e-06 6.643071660407412e-07 0.1544914963260143 0.05149712711509419 9.290140093268049e-11 10.03197773689177 2.4974717564552624 YTVQDESHSEWVSCVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTVQDESHSEWVSCVR 16 0 P63244;J3KPE3;H0Y8W2;H0YAF8;H0YAM7;D6RHH4;D6R9L0;D6R9Z1;D6RFX4;D6RBD0;D6RFZ9 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 68572100.0 7140100.0 33785000.0 27647000.0 False True 9779987.923947275 32292266.987945314 21117348.007838134 1.0 3.3018718672315006 2.159240703777374 23.221401253103714 -9.246785359313517 11.198383927154445 1.000000358289429 2.730556285502843 0.7535990932481865 0.4664772191109356 0.0 0.0 0.4516646252504262 0.15055487508347537 5.665192097682945e-10 9.246785359313517 1.7305559272134141 YTVQFSK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTVQFSK 7 0 Q8IX12-2;Q8IX12;F5H2E6;A0A0C4DGG8;F5H1H2;F5H3E1 Q8IX12-2 CCAR1 Cell division cycle and apoptosis regulator protein 1 0 5822700.0 1716500.0 1014400.0 3091800.0 False True 2250348.122609644 863055.4741002297 2771890.1946398034 1.0 0.3835208719170866 1.231760618186197 21.101716768950215 -6.711807582242257 1.7889378608444717 0.6217045876233273 1.2298621055027943 0.4736405489483315 0.25970809504614784 0.371434435926272 2.3183079063810013 0.1154851523855619 0.29272594533511975 1.941745993640428e-07 6.711807582242257 0.608157517879467 YTVYCSLIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YTVYCSLIK 9 0 Q7L2H7;J3KNJ2;E9PN86 Q7L2H7 EIF3M Eukaryotic translation initiation factor 3 subunit M 0 9219800.0 2936900.0 2681500.0 3601400.0 False True 4022751.296738247 2563022.4634653046 2750823.4931612243 1.0 0.6371317226455115 0.6838164455733728 21.939751116620677 -10.417583613057685 5.284758452295896 1.0002837546621253 0.6604740841094355 0.9860186170688489 0.01905895832610169 6.377150906506102e-05 7.028026537394776e-06 0.018468957399903136 0.006151252349417731 3.823106417647208e-11 10.417583613057685 -0.33980967055268974 YTYLEK(ub)AIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YTYLEKAIK 9 1 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 1 30539400.0 8441400.0 10907000.0 11191000.0 True False 11066757.146633897 9279718.115153015 10033062.671652112 1.0 0.8385218896734863 0.9065946364155829 23.39972920034569 -10.443159410937556 6.466481068774179 1.0000319529668227 0.8725582630474147 0.8237330269221343 0.027790582484640447 1.280527615550928e-05 1.1026823703510446e-06 0.026914856203729704 0.008969371928701331 3.604463143046689e-11 10.443159410937556 -0.127473689919408 YTYLEK(ub)AIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YTYLEKAIK 9 1 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 1 63619700.0 18910000.0 25733700.0 18976000.0 True False 18309712.40081069 36009300.60947263 14005616.332202531 1.0 1.966677565502245 0.7649282536836796 24.126105794441116 -6.692600217959033 1.8573854313819262 1.6045619864540108 0.7689676128902169 0.38258109315978883 0.4086225797385457 0.41107428482646263 2.751587820117959 0.17587393997163522 0.4564573471547702 2.029550126063084e-07 6.692600217959033 -0.835594373563794 YTYLEK(ub)AIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YTYLEKAIK 9 1 Q93009;A0A669KBL1;Q93009-3 Q93009 USP7 Ubiquitin carboxyl-terminal hydrolase 7 1 44437600.0 18910000.0 19483000.0 6044600.0 True False 15724502.855040738 19378041.21192729 7308497.912927348 1.0 1.2323468277863776 0.46478403675474506 23.906511069875393 -6.825505096901583 1.347829373890903 1.1245865839650995 0.4459559564191125 0.896593196571875 0.10334748532660906 0.18642193121394982 0.6638857415092801 0.06022917704735416 0.1386617627765304 1.4944965027784426e-07 6.825505096901583 -0.678630627545987 down YVAEIEK(ub)EKEENEK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVAEIEKEKEENEK 14 2 O14818;O14818-2;H0Y586 O14818 PSMA7 Proteasome subunit alpha type-7 1 6484630.0 875330.0 3868100.0 1741200.0 True False 727875.6786939607 3847261.777542268 2105276.869600819 1.0 5.285602871695717 2.8923577627684334 19.47333253331134 -10.030061940682979 8.542605976250568 0.9999999840038118 4.088980317232076 0.6895601342486253 0.9770382243805653 2.951433379313087e-07 3.6303593062379435e-08 0.9460131929084055 0.3153377309694996 9.331212061132988e-11 10.030061940682979 3.088980333228264 YVAK(ub)ELAVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVAKELAVR 9 1 Q14739;C9JXK0;A0A494C1L1 Q14739 LBR Lamin-B receptor 1 12472420.0 2267820.0 2346100.0 7858500.0 True False 2973133.9816001235 1996071.0250261747 7045377.804054874 1.0 0.6713693487677609 2.369680561877367 21.503553047784894 -6.856538684871792 1.203126031248735 0.8230941030510325 2.446635704321729 0.9492876446659948 0.16562412058958806 0.15041269697191192 0.41570798752746224 0.10751036649062808 0.25005882788920036 1.391429847419809e-07 6.856538684871792 1.6235416012706967 up YVAK(ub)ELAVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVAKELAVR 9 1 Q14739;C9JXK0;A0A494C1L1 Q14739 LBR Lamin-B receptor 1 15215500.0 1643300.0 3899700.0 9672500.0 True False 1591134.340996941 5456870.546666841 7138982.081219905 1.0 3.429547339948545 4.486724908939433 20.60162421826022 -9.077804648325964 0.3048484296008059 3.296356100054443e-20 4.935389527914464 0.9985883539634267 0.05484518396317244 0.5214811757605149 0.10872490614202532 0.949958549915071 0.35578140263805624 8.359789685915626e-10 9.077804648325964 4.935389527914464 YVAK(ub)ELAVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVAKELAVR 9 1 Q14739;C9JXK0;A0A494C1L1 Q14739 LBR Lamin-B receptor 1 38527600.0 3266300.0 15535200.0 19726100.0 True False 4955215.898515794 12762822.182928408 15827227.688743232 1.0 2.5756339268186434 3.194054106398041 22.240516486258134 -9.539420047633826 0.27072583782885246 3.9703053815411436e-25 3.5080169969481076 0.9989335872637352 0.03016421403774185 0.9323101342367738 0.10966774750996182 1.052060474040983 0.24588206085947253 2.887885381654574e-10 9.539420047633826 3.5080169969481076 YVAK(ub)ELAVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVAKELAVR 9 1 Q14739;C9JXK0;A0A494C1L1 Q14739 LBR Lamin-B receptor 1 13368900.0 2267820.0 2198180.0 8902900.0 True False 3106294.339531118 2101057.1391908117 6800218.380981015 1.0 0.676387009580025 2.1891738636743225 21.566763109307786 -6.850760427056974 1.2314443518206872 0.8271936709881724 2.2505320316320585 0.9414011004115508 0.15744787752858527 0.15662256298548533 0.45667331997736993 0.10002853824702938 0.2315831355273915 1.4100664288549696e-07 6.850760427056974 1.423338360643886 up YVAK(ub)ELAVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVAKELAVR 9 1 Q14739;C9JXK0;A0A494C1L1 Q14739 LBR Lamin-B receptor 1 17556300.0 1643300.0 8038200.0 7874800.0 True False 1366476.7605334958 7994896.621142222 9521384.271038666 1.0 5.850737350279472 6.967834760191132 20.382029493694496 -9.37200506718901 0.4695674790149311 4.1528602653224754e-21 7.006862651053532 0.998030942307489 0.1149475896679506 0.7250553336724809 0.19454470243243305 1.5966671467713731 0.23900352710871228 4.246146096696062e-10 9.37200506718901 7.006862651053532 YVAK(ub)ELAVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVAKELAVR 9 1 Q14739;C9JXK0;A0A494C1L1 Q14739 LBR Lamin-B receptor 1 35727300.0 3266300.0 18970700.0 13490300.0 True False 4228289.73839867 17914963.86841445 11035203.822167085 1.0 4.236929107700924 2.609850437152473 22.011642808350583 -8.916677223463404 12.034850425185693 0.9999999916148382 3.4233897724292035 0.7473341035316751 0.6642520857108091 0.0 0.0 0.6431593116143175 0.21438643880207586 1.2114982092657232e-09 8.916677223463404 2.4233897808143654 YVALTSLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVALTSLLK 9 0 O43747;O43747-2 O43747 AP1G1 AP-1 complex subunit gamma-1 0 10219800.0 3083300.0 3912000.0 3224500.0 False True 4042236.158719675 3328344.8488565693 2890859.671588088 1.0 0.8233919835873168 0.71516347835148 21.94672217977539 YVALTSLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVALTSLLK 9 0 O43747;O43747-2 O43747 AP1G1 AP-1 complex subunit gamma-1 0 9764400.0 3179700.0 1621300.0 4963400.0 False True 3078762.16397978 2268693.544967805 3663336.6411917116 1.0 0.7368849635449479 1.1898732172465956 21.553918992049592 -6.749279130170166 1.6529593872713855 0.8451481137240493 1.1906998114519713 0.6456855846384699 0.11055789832346107 0.3013016819070139 1.6195782430972432 0.0528461777452629 0.12837103026426042 1.7812335633026374e-07 6.749279130170166 0.34555169772792205 YVALTSLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVALTSLLK 9 0 O43747;O43747-2 O43747 AP1G1 AP-1 complex subunit gamma-1 0 13016000.0 3083300.0 4407400.0 5525300.0 False True 4223279.333049488 4212666.494677227 4220337.937125478 1.0 0.997487062177202 0.9993035279715002 22.00993224129828 -9.791400928106038 5.059093272918961 1.000000001233047 0.9983952950742765 0.5099276347194313 0.0007415690557751874 1.0380942577973785e-11 2.1148780447243992e-12 0.0007180217015431844 0.00023934038350875649 1.6165869622347208e-10 9.791400928106038 -0.001604706158770508 YVALTSLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVALTSLLK 9 0 O43747;O43747-2 O43747 AP1G1 AP-1 complex subunit gamma-1 0 7257900.0 3179700.0 1692400.0 2385800.0 False True 2644061.434594021 1683282.7052849003 2884659.749307166 1.0 0.6366276831776254 1.0909957354111506 21.33432426748387 -6.693721012414585 1.8530923942151407 0.7729892720797001 1.089504096414278 0.3879391452204761 0.15356661139693825 0.40872115282182625 2.72396764176733 0.066223487964726 0.17165254118468334 2.0243191688475628e-07 6.693721012414585 0.3165148243345778 YVASAVFGVIGSQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVASAVFGVIGSQK 14 0 Q9UNX4;Q6PDA5 Q9UNX4 WDR3 WD repeat-containing protein 3 0 4946600.0 1486700.0 1109000.0 2350900.0 False True 2036373.166556831 1060000.713027419 1795665.8383053036 1.0 0.5205336283328189 0.8817960616430025 20.95757052966217 -9.755102879239514 6.032319870552378 1.0000000092430241 0.7011648449870255 0.4770803133062589 0.14748477081085287 1.843222752823051e-08 3.527512851680145e-09 0.14280152167474877 0.047600505097008604 1.7575072319122167e-10 9.755102879239514 -0.29883516425599865 YVASYLLAALGGNSSPSAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVASYLLAALGGNSSPSAK 19 0 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 1133904690.0 252001400.0 451111700.0 430791590.0 False True 330376275.7850294 383807592.7796343 386217408.71152353 1.0 1.1617286739722552 1.1690228294807374 28.29953485010515 -12.680984220017363 0.4594205855422492 1.2334932608746435e-12 1.1689454712399263 0.9998832350123835 0.0008430014181391077 10.889457670974968 0.23094230102118463 10.637067249018541 0.0016127410061268852 2.0845666239342183e-13 12.680984220017363 1.1689454712386929 YVASYLLAALGGNSSPSAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVASYLLAALGGNSSPSAK 19 0 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 3780192100.0 1827608000.0 1033031000.0 919553100.0 False True 1769591584.4220417 1445525665.485497 678694557.1083187 1.0 0.816869654111524 0.3835317499715529 30.72076928371907 -6.956628578375009 0.480597218741923 1.010343092128993 0.1719730397311274 0.9996240047096207 0.005012263369944042 0.0809281716340174 0.025753732485769527 0.006117361957718325 0.03574598294742722 1.1050232648330805e-07 6.956628578375009 -0.8383700523978657 down YVASYLLAALGGNSSPSAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVASYLLAALGGNSSPSAK 19 0 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 2103569000.0 646789000.0 751390000.0 705390000.0 False True 981226199.6096884 617298583.863134 565969357.3165798 1.0 0.629109357361924 0.5767980487493208 29.870010514745683 -13.999999999999998 0.2759229545757948 3.955916828341736 0.5604069309521447 0.9995961942078545 0.0037855536676565833 15.182060476040368 0.16634476853473928 25.26265878295855 0.021101742735267468 1.0000000000000041e-14 13.999999999999998 -3.395509897389591 YVASYLLAALGGNSSPSAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVASYLLAALGGNSSPSAK 19 0 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 2723708700.0 252001400.0 814828400.0 1656878900.0 False True 345173127.6617709 778826587.0108111 1265558228.3120804 1.0 2.256336095126066 3.666444826933859 28.36274491162804 -6.969628832169891 0.2669026496751876 0.6360304623869626 5.3289680224200655 0.9999793412158168 0.004950506727035947 0.07642333853873033 0.009460268198291558 0.028175087938818472 0.13171559424814308 1.0724354658440101e-07 6.969628832169891 4.692937560033103 YVASYLLAALGGNSSPSAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVASYLLAALGGNSSPSAK 19 0 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 3009417500.0 1827608000.0 708827800.0 472981700.0 False True 1519737028.76231 705009203.9500977 571879986.6497091 1.0 0.4639021031975938 0.37630193633924564 30.501174559153345 -13.999999999999998 0.2549285376365788 4.822911577828262 0.3426945264466046 0.9995521683605845 0.005834282679480893 14.198809159329745 0.15976657261436744 27.87834756396289 0.039348636702236255 1.0000000000000041e-14 13.999999999999998 -4.480217051381658 YVASYLLAALGGNSSPSAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVASYLLAALGGNSSPSAK 19 0 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 0 2287551800.0 646789000.0 1137600000.0 503162800.0 False True 837281110.6172526 1074291559.9692318 411592333.28630954 1.0 1.283071535170849 0.4915820123815755 29.641136836838132 -6.809991750314708 1.4145442192823197 1.15427258090765 0.4777345064611174 0.859813277718929 0.12260621780518373 0.2068108571935379 0.8155929896372294 0.06815305838770262 0.1576543574058756 1.5488460398965592e-07 6.809991750314708 -0.6765380744465326 down YVASYLLAALGGNSSPSAK(ub)DIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVASYLLAALGGNSSPSAKDIK 22 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 504193600.0 213204000.0 196964000.0 94025600.0 True False 206435955.72196928 275612752.3536907 69397474.65246318 1.0 1.3351005225314996 0.33616951276612217 27.62111903133315 -6.81622434395106 1.3879850746670068 1.1813375542127953 0.31605306268218425 0.8755108025629865 0.14646241019439313 0.19843323020854967 0.7521346651189503 0.08293961311920775 0.19139486692356136 1.5267771656317298e-07 6.81622434395106 -0.865284491530611 down YVASYLLAALGGNSSPSAK(ub)DIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVASYLLAALGGNSSPSAKDIK 22 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 321951900.0 148253000.0 85767000.0 87931900.0 True False 224910639.74609205 70461208.74937035 70552121.4230792 1.0 0.31328535114619743 0.313689568011222 27.744776670751943 -10.01337471041046 5.021893399232184 1.0000075897427658 0.3134874595721839 0.9999997396698588 0.00016502086672017736 455534.2992115861 0.07421175097891103 40.13573830081509 5.649102853743933e-05 9.696729698509561e-11 10.01337471041046 -0.6865201301705819 YVASYLLAALGGNSSPSAK(ub)DIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVASYLLAALGGNSSPSAKDIK 22 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 172504300.0 53369300.0 81964200.0 37170800.0 True False 73101372.46110271 78342750.62463656 28391822.59665607 1.0 1.0717001334868617 0.3883897338830865 26.12339515690415 -6.880981719246859 1.0743511592276815 1.0450375000609793 0.3390512259172728 0.9744669238926874 0.04899441565640463 0.12676209584558254 0.26708436093089416 0.03509904997132766 0.08509113632414354 1.3152801951027028e-07 6.880981719246859 -0.7059862741437064 down YVASYLLAALGGNSSPSAK(ub)DIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVASYLLAALGGNSSPSAKDIK 22 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 513390400.0 213204000.0 256354000.0 43832400.0 True False 177288572.53866223 254972970.11971492 52997552.1818809 1.0 1.438180512531972 0.2989338310021276 27.401524306767428 -6.802406250184041 1.4458845856529838 1.2410212330242982 0.2822145825788544 0.8391935638527026 0.18815433533387588 0.21731362171733626 0.896627624377973 0.10235917213927154 0.237729096779504 1.5761362217091405e-07 6.802406250184041 -0.9588066504454438 down YVASYLLAALGGNSSPSAK(ub)DIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVASYLLAALGGNSSPSAKDIK 22 1 P05387 P05387 RPLP2 60S acidic ribosomal protein P2 1 321445500.0 148253000.0 134205000.0 38987500.0 True False 191916431.0035259 126736373.77432363 31892175.0455319 1.0 0.660372710724259 0.16617740794140742 27.515902992844392 -7.3954458884898795 0.46328282687126165 1.0188507507233195 1.5757790669135177e-22 0.9985013692639945 0.013253129876325596 0.1103081121443031 0.05088979774776851 0.016473098050153373 0.06148606116202055 4.0230377846110755e-08 7.3954458884898795 -1.0188507507233195 down YVATLGVEVHPLVFHTNR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVATLGVEVHPLVFHTNR 18 0 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 243946000.0 80466000.0 99050000.0 64430000.0 False True 105491705.23385234 84272126.093876 57763401.65620111 1.0 0.7988507334018622 0.5475634461321117 26.652554324017643 -6.968118448628539 0.2997414095997023 1.0437157703343025 0.2948274255026249 0.9999637607229859 0.0011141741453168763 0.07691808513724224 0.011203822864865995 0.004174288457210623 0.022543010530795913 1.0761716606438485e-07 6.968118448628539 -0.7488883448316777 YVATLGVEVHPLVFHTNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVATLGVEVHPLVFHTNR 18 0 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 721475000.0 251501000.0 302553000.0 167421000.0 False True 243517238.41968712 423363990.6930516 123568417.5776602 1.0 1.7385380741030314 0.5074319106916676 27.859448662422192 -6.744240716211766 1.6710481611322099 1.4372591210454686 0.5060049878247673 0.6238516780263615 0.31029143006654797 0.3102081136246803 1.7023478026639822 0.14679955871357658 0.35858678506854447 1.8020186599137867e-07 6.744240716211766 -0.9312541332207013 YVATLGVEVHPLVFHTNR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVATLGVEVHPLVFHTNR 18 0 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 4155426100.0 1476790000.0 1350590000.0 1328046100.0 False True 2240398397.8107133 1109566662.2921662 1065557206.2317162 1.0 0.4952541759431803 0.4756105910774459 31.061108155661547 YVATLGVEVHPLVFHTNR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVATLGVEVHPLVFHTNR 18 0 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 456052000.0 80466000.0 153497000.0 222089000.0 False True 110216454.7118865 146714994.99330005 169636152.26653066 1.0 1.3311532781273294 1.5391182079842016 26.715764385540535 -9.529342264188584 0.08265304820774386 9.567113859926626e-14 2.323491424818256 0.9999735322434656 0.001142110488088189 1.0175400758221522 0.033398651436568734 0.574907534997038 0.35779832731036015 2.9556821977070463e-10 9.529342264188584 2.3234914248181604 YVATLGVEVHPLVFHTNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVATLGVEVHPLVFHTNR 18 0 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 547816000.0 251501000.0 102442000.0 193873000.0 False True 209134224.88342655 101890124.6128551 234410947.93252912 1.0 0.4871996664804608 1.120863637040719 27.63985393785647 -6.691397527028201 1.86134407118861 0.6789273877171103 1.1187164194004435 0.376987744561993 0.2168176424958226 0.41369128226292157 2.7799192167548465 0.09314609364177265 0.24214194661690602 2.0351783451034327e-07 6.691397527028201 0.4397890316833333 YVATLGVEVHPLVFHTNR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVATLGVEVHPLVFHTNR 18 0 B5MDF5;P62826;J3KQE5;F5H018;H0YFC6 B5MDF5 RAN GTP-binding nuclear protein Ran 0 3394339700.0 1476790000.0 1090979700.0 826570000.0 False True 1911733766.882946 1030265720.646769 676142741.3244082 1.0 0.5389169446573109 0.3536803884710626 30.832234477753996 -13.999999999999998 0.1256972671855699 3.191606840469244 0.07951508669932017 0.9996655072448406 0.004970096123316995 11.945478637558203 0.10980445759263205 6.4954397526552885 0.24350186640321048 1.0000000000000041e-14 13.999999999999998 -3.112091753769924 YVAVMPPHIGDQPLTGAYTVTLDGR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVAVMPPHIGDQPLTGAYTVTLDGR 25 0 P30043;A0A2R8YEP4 P30043 BLVRB Flavin reductase (NADPH) 0 21548400.0 5471400.0 16077000.0 0.0 False True 8300513.8129196055 13207933.739825659 0.0 1.0 1.591218813378485 0.0 22.984769213302727 -6.822516196887711 1.4710908153436326 1.322642154332108 2.396835697612208e-20 0.8487956114072199 0.2553651860334283 0.20290921619814398 0.8797248788217347 0.13865326228838734 0.3034223684544598 1.5048173960242867e-07 6.822516196887711 -1.322642154332108 YVDIAIPCNNK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVDIAIPCNNK 11 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 23980300.0 3670400.0 11809000.0 8500900.0 False True 4811929.94420416 10047143.23112146 7621308.414390804 1.0 2.0879654000829695 1.5838361120719275 22.198184208121422 -10.487157378953306 5.542124886295102 0.998797967171841 1.83590075607742 0.7856727559828366 0.2058099200032779 0.0030604290343304694 0.0002831978295638936 0.19951383074265963 0.06642486605474716 3.257186462008147e-11 10.487157378953306 0.8371027889055791 YVDIAIPCNNK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVDIAIPCNNK 11 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 12066300.0 5693000.0 3636200.0 2737100.0 False True 5512278.83119065 5088153.622532492 2020171.3987600924 1.0 0.923058099626911 0.3664857059351143 22.394217435995138 -6.932019760828863 0.7300253402077045 1.007861814555273 0.24611738532466085 0.9969204711937322 0.015663560818960965 0.09160266985695137 0.07264201971841715 0.014445663295204612 0.04981272311140886 1.1694461788504272e-07 6.932019760828863 -0.761744429230612 down YVDIAIPCNNK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVDIAIPCNNK 11 0 C9J9K3;A0A0C4DG17;P08865 C9J9K3 RPSA 40S ribosomal protein SA 0 31644400.0 3670400.0 12518000.0 15456000.0 False True 5027446.068830419 11964913.368509673 11805611.126311956 1.0 2.379918790713787 2.3482322763252244 22.261394269644313 -10.212208939794417 5.43139523670106 0.9999282225559284 2.3640755335195367 0.9995954634894959 0.012935965330427533 1.124521499606695e-05 1.6310806295886346e-06 0.012525843513723742 0.004175064857577275 6.134667942666656e-11 10.212208939794417 1.3641473109636082 YVDKLEK(ub)IFQNAPTDPTQDFSTQVAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVDKLEKIFQNAPTDPTQDFSTQVAK 26 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 365079600.0 135710000.0 148476600.0 80893000.0 True False 177917124.21750936 126324470.03725371 72522968.34044811 1.0 0.7100186145253675 0.4076221929699497 27.406630133305622 -6.970597635235312 0.2434932956727354 1.103985098024694 0.004871327756882857 0.9999866743708247 0.00088285528407361 0.07610928876502798 0.008333457414003332 0.007053152936161228 0.029300449457448023 1.0700457951953501e-07 6.970597635235312 -1.099113770267811 down YVDKLEK(ub)IFQNAPTDPTQDFSTQVAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVDKLEKIFQNAPTDPTQDFSTQVAK 26 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 2655114000.0 1011730000.0 734400000.0 908984000.0 True False 979613184.9430033 1027649749.8454074 670893821.4645215 1.0 1.0490362580258645 0.6848558510403839 29.867636950848762 -6.8729402821197025 1.1184872353298885 1.0282900259250023 0.6623070472690976 0.9675275419830953 0.029078146518564503 0.13406374113150848 0.3116837059725768 0.020138904961929254 0.047936294389324445 1.3398609130056867e-07 6.8729402821197025 -0.3659829786559047 YVDKLEK(ub)IFQNAPTDPTQDFSTQVAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVDKLEKIFQNAPTDPTQDFSTQVAK 26 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 2764600000.0 1071650000.0 963220000.0 729730000.0 True False 1625771398.1093116 791325865.3277893 585498545.6479794 1.0 0.48673870523744023 0.36013583848804576 30.59847726638078 -13.999999999999998 0.1965853725275451 3.8168919009398605 0.2750915028944744 0.9994871135801031 0.006265627930721188 12.465464090258283 0.14059998724634146 13.482843952659328 0.08271599192340551 1.0000000000000041e-14 13.999999999999998 -3.5418003980453863 YVDKLEK(ub)IFQNAPTDPTQDFSTQVAK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVDKLEKIFQNAPTDPTQDFSTQVAK 26 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 630472000.0 135710000.0 123480000.0 371282000.0 True False 185885654.42485178 118024245.30624503 283592838.39281505 1.0 0.6349292831199023 1.5256305779500778 27.469840194828514 -6.795414710436906 1.4744589539862663 0.7973803995557638 1.536588587876134 0.8184061812847734 0.15579243748164717 0.22739370621137536 0.9763783058373493 0.08313974489299224 0.1939259423542772 1.6017151726584072e-07 6.795414710436906 0.7392081883203703 YVDKLEK(ub)IFQNAPTDPTQDFSTQVAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVDKLEKIFQNAPTDPTQDFSTQVAK 26 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 2235455000.0 1011730000.0 777755000.0 445970000.0 True False 841298322.2385173 773565079.4427195 539220265.0676982 1.0 0.9194896257304139 0.640938238926885 29.64804222628304 -6.948209740962418 0.5781733599413115 1.0033529314979073 0.5433407282822509 0.9990531236666749 0.00473383332587924 0.08421289679306798 0.03900111524796678 0.004969675505310051 0.023257470876361774 1.1266532116378482e-07 6.948209740962418 -0.4600122032156564 YVDKLEK(ub)IFQNAPTDPTQDFSTQVAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVDKLEKIFQNAPTDPTQDFSTQVAK 26 2 P45974-2;P45974 P45974-2 USP5 Ubiquitin carboxyl-terminal hydrolase 5 1 1702751000.0 1071650000.0 176230000.0 454871000.0 True False 1387272050.379613 166422645.5813798 372089145.3705972 1.0 0.11996395770810775 0.26821642176729416 30.36960358847323 -10.21509756196575 5.984407396291693 1.000016184917384 0.1940901897376964 0.9752481670133817 0.06052381500923639 1.3069758897117861e-05 1.714248500531926e-06 0.05860310649572488 0.019533977298306585 6.093999833687602e-11 10.21509756196575 -0.8059259951796877 YVDMSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVDMSVK 7 0 P48047 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 4357540.0 960370.0 593270.0 2803900.0 False True 929883.5800299603 830165.8048621787 2069474.474803046 1.0 0.8927631616373216 2.2255199674956825 19.826690578800417 -6.887419105959817 1.0375671672663704 0.9238957844659016 2.334501042392094 0.9791928742982108 0.08720852728450525 0.12126059566005781 0.23429901483838306 0.06425120306815743 0.1587554731159203 1.2959280616105005e-07 6.887419105959817 1.4106052579261927 up YVDMSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVDMSVK 7 0 P48047 P48047 ATP5O ATP synthase subunit O, mitochondrial 0 5371300.0 1268700.0 1345300.0 2757300.0 False True 1737772.6753283425 1285860.1976878126 2106082.5283760335 1.0 0.7399472991741319 1.2119436323730324 20.728807939378445 -6.757126167143394 1.6231895156792495 0.8484064334452881 1.2134321443251985 0.679134669202826 0.10933899639022467 0.28778816787667816 1.4937333600285503 0.05316408101247284 0.12813184130660354 1.7493384134751568e-07 6.757126167143394 0.3650257108799104 YVDSSK(ub)AVIETADR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVDSSKAVIETADR 14 1 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 3824600.0 1109200.0 1374300.0 1341100.0 True False 1454171.941508078 1169259.7969794427 1202335.8367395822 1.0 0.8040725883947661 0.8268182065820057 20.471766433145074 -9.998245292040249 5.639296975969306 1.0000004139353469 0.8154453975543606 0.9887361316697455 0.009285859740890124 4.832723814639843e-08 8.576538923306484e-09 0.008991015262932089 0.0029969983442480765 1.0040485376668502e-10 9.998245292040249 -0.18455501638098626 YVDSSK(ub)AVIETADR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVDSSKAVIETADR 14 1 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 7231400.0 2164300.0 2334000.0 2733100.0 True False 2095595.4811779256 3265978.371649209 2017219.1187575178 1.0 1.558496571014467 0.9625994791817585 20.99892882550218 -8.74600721980872 18.430954945258613 1.0000040575078335 1.2605480250980778 0.2031244779801319 0.24327396904437174 0.0 0.0 0.23554900766356032 0.07851633588785342 1.7947037910268163e-09 8.74600721980872 0.26054396759024434 YVDSSK(ub)AVIETADR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVDSSKAVIETADR 14 1 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 21582300.0 4307700.0 5309600.0 11965000.0 True False 6535095.835053872 4362060.395905847 9600112.505554203 1.0 0.6674822383641277 1.4690086798819018 22.639776962153327 -6.794029452015499 1.4801230789187776 0.8151251662478879 1.4785141230147278 0.8141395923197363 0.1417504854841031 0.2293946567011431 0.9926480878646772 0.07536419943281607 0.17594798111911492 1.6068322807465533e-07 6.794029452015499 0.66338895676684 YVDSSK(ub)AVIETADR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVDSSKAVIETADR 14 1 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 4311400.0 1109200.0 1228900.0 1973300.0 True False 1519301.2150029142 1174603.1345711397 1507247.181389195 1.0 0.77312064452531 0.9920660672849549 20.534976494667966 -10.67366315643603 8.56754208007324 1.0001878399806725 0.8825933559206739 0.2771433784470895 0.0893840945465128 0.0003212142955708609 1.2234983535035751e-05 0.08668306276240985 0.028848592466206094 2.1200047967199843e-11 10.67366315643603 -0.11759448405999862 YVDSSK(ub)AVIETADR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVDSSKAVIETADR 14 1 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 6809800.0 2164300.0 3009800.0 1635700.0 True False 1799711.344746942 2993585.610001476 1977717.3073777047 1.0 1.6633698613609647 1.0989080627570262 20.779334100936456 -10.393375704251651 3.662375578319208 0.9977164605651863 1.3811389621386854 0.37807303514227253 0.23044056459316592 55021964.27412488 3391.8139279755706 1061458.7271350718 0.07888593457913369 4.04226048076089e-11 10.393375704251651 0.3834225015734991 YVDSSK(ub)AVIETADR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVDSSKAVIETADR 14 1 Q08752 Q08752 PPID Peptidyl-prolyl cis-trans isomerase D 1 18418200.0 4307700.0 3570500.0 10540000.0 True False 5576402.567461633 3371798.5362782525 8621828.149532704 1.0 0.6046547923122932 1.5461272828187047 22.410903284245776 -6.792623386302204 1.4857381526774556 0.7797939519317054 1.556891196772195 0.8097456063956546 0.16836354437553094 0.23145957863308167 1.0092599673614047 0.08918125273369817 0.20841205250829906 1.6120429688383987e-07 6.792623386302204 0.7770972448404896 YVDTPFGK(ub)PSDALILGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVDTPFGKPSDALILGK 17 1 B4DUC8;Q13126;Q13126-4;Q13126-3;Q13126-2;J3QSB7;Q13126-7;Q13126-6;Q13126-5;F2Z2F3 B4DUC8 MTAP S-methyl-5-thioadenosine phosphorylase;Purine nucleoside phosphorylase 1 7214700.0 2759900.0 1333500.0 3121300.0 True False 2672288.48519288 1865973.5041106322 2303737.893007151 1.0 0.6982679880746298 0.8620842793628518 21.3496443307631 -10.286145687565718 4.884316661599529 1.0000716774817158 0.7801761337185729 0.7059602667002676 0.06687772086915908 5.221706198729259e-05 7.631696451532594e-06 0.06477514593923243 0.02158469159645951 5.1743322570953765e-11 10.286145687565718 -0.2198955437631429 YVDTPFGK(ub)PSDALILGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVDTPFGKPSDALILGK 17 1 B4DUC8;Q13126;Q13126-4;Q13126-3;Q13126-2;J3QSB7;Q13126-7;Q13126-6;Q13126-5;F2Z2F3 B4DUC8 MTAP S-methyl-5-thioadenosine phosphorylase;Purine nucleoside phosphorylase 1 27756200.0 3920600.0 6369600.0 17466000.0 True False 5075293.986579866 6015126.1606716 14287367.21629397 1.0 1.1851778786759637 2.8150816985326848 22.27505996220261 -6.928362778143251 0.7601025130812313 0.9736504035096887 3.136165092938005 0.996206723176696 0.05022645889145873 0.09349685123030087 0.08190822880819874 0.04532085642834844 0.14882794377163278 1.1793350929959458e-07 6.928362778143251 2.162514689428316 up YVECSALTQK(ub)GLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVECSALTQKGLK 13 1 P60953 P60953 CDC42 Cell division control protein 42 homolog 1 19105000.0 7462600.0 8514500.0 3127900.0 True False 9783540.867921194 7244169.789261055 2804254.9129354516 1.0 0.7404445779966672 0.28662985628548815 23.22192527049982 -6.9935864521054 0.4043362922950387 1.0242449161721392 9.196047394549227e-11 0.9998537797116538 0.003564878439609909 0.07505219298509637 0.01796980971237389 0.005772216223177749 0.036185451877296514 1.0148773216051672e-07 6.9935864521054 -1.0242449160801788 down YVECSALTQK(ub)GLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVECSALTQKGLK 13 1 P60953 P60953 CDC42 Cell division control protein 42 homolog 1 16260030.0 7462600.0 5627630.0 3169800.0 True False 10221724.88918207 5378982.698516222 2421158.5240802006 1.0 0.5262304314420501 0.23686398825335034 23.285135332022712 -8.543903187098698 0.2401783880710736 1.2563017870618876 9.746323841117983e-26 0.9994181020631056 0.007588140359474118 0.18178398107631033 0.06433511430289651 0.14500681453351894 0.11377489090166873 2.8582276283038185e-09 8.543903187098698 -1.2563017870618876 down YVECSALTQK(ub)GLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVECSALTQKGLK 13 1 P60953 P60953 CDC42 Cell division control protein 42 homolog 1 12495830.0 8637230.0 1972200.0 1886400.0 True False 7182239.439166755 1961575.3671489516 2280837.51827187 1.0 0.27311472748345506 0.317566343699686 22.77600231922738 -9.766841124865328 6.272641195881956 1.000000012966302 0.29534053559090573 0.9970243379878485 0.018147296331009637 3.2705696338532455e-09 6.678627681089536e-10 0.017571044377952177 0.0058570147053746205 1.7106409933434697e-10 9.766841124865328 -0.7046594773753962 YVEFNLLYDR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVEFNLLYDR 10 0 P36551;H0YA22 P36551 CPOX Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial 0 13275400.0 4171400.0 2864500.0 6239500.0 False True 6328318.770189134 2353307.5945593473 5006260.09013 1.0 0.37186931948578406 0.7910884820962295 22.5933908424263 -10.106373129526128 5.907259680859615 1.000002202071294 0.5814789007910971 0.5706121133454463 0.17114550646546822 4.963606304781593e-06 7.505422968894585e-07 0.16571179682288906 0.05523697469324035 7.827568384732994e-11 10.106373129526128 -0.4185233012801969 YVELFLNSTAGASGGAYEHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVELFLNSTAGASGGAYEHR 20 0 P31943;G8JLB6;H0YB39 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 20692200.0 7811700.0 9866700.0 3013800.0 False True 10241214.348610401 8394626.820095366 2701960.886410972 1.0 0.8196905693351109 0.2638320803018436 23.287883456780552 -6.950836898681042 0.5495783573174277 1.0077066341026835 0.04972144371971804 0.9992653380346388 0.008491986982856253 0.08315140645601457 0.034584876706394894 0.009222001403632989 0.04610951462823633 1.1198583725406008e-07 6.950836898681042 -0.9579851903829655 down YVELFLNSTAGASGGAYEHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVELFLNSTAGASGGAYEHR 20 0 P31943;G8JLB6;H0YB39 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 67589000.0 25806000.0 14659000.0 27124000.0 False True 24986802.655490257 20512415.145675123 20019410.69744209 1.0 0.8209299696521198 0.8011993760651605 24.5746629682698 -13.999999999999998 0.31143148070846016 2.745521415151758 0.7968965659389224 0.999675134578278 0.0016118504929138917 17.3719673086638 0.17761442668475985 19.665432508050273 0.006797376494719242 1.0000000000000041e-14 13.999999999999998 -1.9486248492128355 YVELFLNSTAGASGGAYEHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVELFLNSTAGASGGAYEHR 20 0 P31943;G8JLB6;H0YB39 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 292085000.0 38779000.0 176140000.0 77166000.0 False True 58830578.124649875 144706440.81189862 61914106.276940756 1.0 2.4597147508102926 1.0524136979541068 25.81006287781219 -6.637683492093604 2.053231121422646 1.956272984911319 1.0582854823705774 0.1456186046486616 0.6249385853646359 0.5392496944998647 4.342108563696051 0.24813289895008747 0.691853415387613 2.3031196882061314e-07 6.637683492093604 -0.8979875025407416 YVELFLNSTAGASGGAYEHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVELFLNSTAGASGGAYEHR 20 0 P31943;G8JLB6;H0YB39 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 42525400.0 7811700.0 8631700.0 26082000.0 False True 10699896.59325484 8250322.952785183 19921968.775651395 1.0 0.7710656716052886 1.861884234302797 23.351093518303443 -6.851914585215498 1.225909200169738 0.8776090863807047 1.907104769250268 0.9430322367282367 0.11209569998641473 0.15536517090675306 0.44836758578539143 0.0715161135393754 0.16569825403234198 1.4063240854543232e-07 6.851914585215498 1.0294956828695634 YVELFLNSTAGASGGAYEHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVELFLNSTAGASGGAYEHR 20 0 P31943;G8JLB6;H0YB39 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 51784000.0 25806000.0 11216000.0 14762000.0 False True 21458832.399639416 11155577.181798311 17848665.948223785 1.0 0.5198594673765085 0.8317631460938063 24.355068243704075 -10.135295848915446 5.268845684085175 1.000009011666879 0.675811306734946 0.5902368772849796 0.12733414362647014 1.3479712606851641e-05 2.2123645251037596e-06 0.12329418022385971 0.041096918138967986 7.323254903848235e-11 10.135295848915446 -0.3241977049319329 YVELFLNSTAGASGGAYEHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVELFLNSTAGASGGAYEHR 20 0 P31943;G8JLB6;H0YB39 P31943 HNRNPH1 Heterogeneous nuclear ribonucleoprotein H;Heterogeneous nuclear ribonucleoprotein H, N-terminally processed 0 150025000.0 38779000.0 68571000.0 42675000.0 False True 50200179.948370315 64754963.57124655 34908587.882477045 1.0 1.2899348894335734 0.695387704155238 25.58118919990464 -6.774112190721163 1.5588220553300012 1.1654240894375032 0.6915198243384645 0.7460039365149658 0.12233995108558515 0.25983042752367863 1.2465667087195744 0.06184286853249457 0.14665690931183212 1.6822394342385353e-07 6.774112190721163 -0.4739042650990387 YVENNK(ub)NADNDWFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVENNKNADNDWFR 14 1 Q9Y3C8 Q9Y3C8 UFC1 Ubiquitin-fold modifier-conjugating enzyme 1 1 7126300.0 1621500.0 1642000.0 3862800.0 True False 2221012.3693898576 1569451.010632118 2950486.1968632094 1.0 0.7066376721995778 1.3284420373011017 21.08278599697166 -6.778405330440626 1.5419619233723636 0.8335441966486731 1.3331329182054175 0.7617231170519486 0.12397934855988345 0.25307369983297057 1.1883832575637194 0.06333291573795885 0.14964712243654085 1.6656918835857555e-07 6.778405330440626 0.4995887215567444 YVEQLLTLFNR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVEQLLTLFNR 11 0 Q93034 Q93034 CUL5 Cullin-5 0 4933400.0 2298200.0 1001100.0 1634100.0 False True 2225244.89897108 1400844.4506675345 1206080.1880508086 1.0 0.629523721777888 0.5419988553208154 21.0855326897126 -13.99999999999999 0.20269333100306647 3.08086693470666 0.4866412173871381 0.9994872430094952 0.004495225737868146 12.58551266784954 0.14274420224249315 10.394611713987642 0.0546327470227874 1.0000000000000246e-14 13.99999999999999 -2.594225717319522 YVEQLLTLFNR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVEQLLTLFNR 11 0 Q93034 Q93034 CUL5 Cullin-5 0 4760240.0 2298200.0 655140.0 1806900.0 False True 1911055.127522719 651610.6307848922 2184714.4358383412 1.0 0.3409690392498349 1.143198018923904 20.865937965146877 -6.688420507146652 1.872104015040888 0.5862214631957797 1.1403700103381569 0.3630446948930055 0.2788131498297038 0.4200518028260275 2.853082294345835 0.11919971073682975 0.31101506852860034 2.0491770950799577e-07 6.688420507146652 0.5541485471423772 YVETQAK(ub)ENAYDLEANLAVLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVETQAKENAYDLEANLAVLK 21 1 Q9UBQ5-2;Q9UBQ5;K7ERF1;K7ES31 Q9UBQ5-2 EIF3K Eukaryotic translation initiation factor 3 subunit K 1 27427700.0 5117100.0 7190600.0 15120000.0 True False 4954660.461458922 10061844.078483637 11159618.409722917 1.0 2.030783775548745 2.252347763591638 22.24035476349607 -10.626386056693798 0.31332305038814184 6.328115712954721e-14 2.3127766730252106 0.999137419173014 0.01602671270304337 2.239741771585717 0.15336142339264006 1.8061472674954144 0.07527163194998811 2.363817498792961e-11 10.626386056693798 2.3127766730251476 YVETQAK(ub)ENAYDLEANLAVLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVETQAKENAYDLEANLAVLK 21 1 Q9UBQ5-2;Q9UBQ5;K7ERF1;K7ES31 Q9UBQ5-2 EIF3K Eukaryotic translation initiation factor 3 subunit K 1 138583100.0 7881300.0 26541000.0 104160800.0 True False 11956508.300208952 21804551.18422053 83573372.22469959 1.0 1.8236554215279952 6.98978080609362 23.51129280011426 -6.934903081440392 0.7053833540198452 0.9338802013756138 8.196191944600491 0.9974172096429751 0.13472106509160153 0.09017063397641167 0.06578550858324106 0.12653836555984874 0.45550408008074966 1.1617078353884535e-07 6.934903081440392 7.262311743224878 YVETQAK(ub)ENAYDLEANLAVLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVETQAKENAYDLEANLAVLK 21 1 Q9UBQ5-2;Q9UBQ5;K7ERF1;K7ES31 Q9UBQ5-2 EIF3K Eukaryotic translation initiation factor 3 subunit K 1 21160200.0 5117100.0 8552700.0 7490400.0 True False 4255095.3759666225 8506624.907521961 9056608.00830346 1.0 1.9991619824948168 2.1284148081512946 22.020760038930348 -10.851824323834244 0.38563243476721915 1.8786986289951816e-10 2.1419775645438746 0.9994185212690543 0.012159253908074171 2.5374044548491494 0.18810625631598699 2.34742789308545 0.0343469378253024 1.4066163985081785e-11 10.851824323834244 2.141977564356005 YVETQAK(ub)ENAYDLEANLAVLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVETQAKENAYDLEANLAVLK 21 1 Q9UBQ5-2;Q9UBQ5;K7ERF1;K7ES31 Q9UBQ5-2 EIF3K Eukaryotic translation initiation factor 3 subunit K 1 184591300.0 7881300.0 26078000.0 150632000.0 True False 10202498.213648906 24626736.375595666 123218521.61483988 1.0 2.4137947255555514 12.077289212361547 23.282419122206708 -6.9331438646969765 0.7205174741011624 0.8688100280259391 14.229930834129988 0.9971208871720683 0.26413396372150993 0.09103791554386369 0.06992148364683053 0.2453078995210251 0.8597642997489375 1.166423162894744e-07 6.9331438646969765 13.361120806104049 YVFCPETTDDEK(ub)K ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVFCPETTDDEKK 13 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;A0A0A0MSJ3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 4309200.0 1262600.0 1646200.0 1400400.0 True False 1655280.8270357924 1400593.376837341 1255500.0415853471 1.0 0.8461364101857357 0.7584815948322461 20.658644567868585 -13.999999999999527 0.0644796622443801 1.9352273752120297 0.40072979783512447 0.999941893481321 0.000760934159424631 12.417728990753552 0.066634284671909 1.8124112193852129 0.3325953940590724 1.000000000001088e-14 13.999999999999527 -1.5344975773769052 YVFCPETTDDEK(ub)K ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVFCPETTDDEKK 13 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;A0A0A0MSJ3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 16778800.0 3321900.0 5251800.0 8205100.0 True False 5039565.163420258 4314575.257499317 6583358.388576915 1.0 0.85614038465396 1.3063346092560322 22.26486782613644 -6.820730038465095 1.3685735436723416 0.9225125551998182 1.3163272901042622 0.886060619248457 0.06337091980029036 0.1925516926510329 0.7084325504808018 0.03638358064543185 0.08384814336262204 1.5110191259983477e-07 6.820730038465095 0.39381473490444396 YVFCPETTDDEK(ub)K ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVFCPETTDDEKK 13 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;A0A0A0MSJ3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 4551600.0 1262600.0 1023600.0 2265400.0 True False 1729417.340482042 978373.9674074536 1730359.1773775276 1.0 0.5657246197929012 1.0005445978095855 20.721854629391476 -10.946656727161105 10.551321681071213 1.0593400924690641 0.7831346088012434 0.24906065079264905 0.17751451268484586 0.10277843845048663 0.0005196062319805744 0.0712903516139336 0.057292562611544424 1.1306892752384447e-11 10.946656727161105 -0.2762054836678207 YVFCPETTDDEK(ub)K ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVFCPETTDDEKK 13 1 E9PFK9;Q9UJ41;Q9UJ41-4;Q9UJ41-3;Q3HKR1;A0A0A0MSJ3 E9PFK9 RABGEF1 Rab5 GDP/GTP exchange factor 1 15731800.0 3321900.0 4584700.0 7825200.0 True False 4300265.034438514 4329557.414724799 6401093.893332394 1.0 1.0068117616127605 1.4885347396194115 22.03599414822889 -6.909979795816326 0.8958725873264028 0.985075246084929 1.550762374232736 0.9909138866849807 0.021800779319212298 0.10443152182626808 0.13884000022675266 0.017846783604319374 0.049258290003615555 1.230326006525581e-07 6.909979795816326 0.5656871281478071 YVFGYQK(ub)NSNIQAK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVFGYQKNSNIQAK 14 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 13631800.0 4025000.0 3481100.0 6125700.0 True False 5276813.978155451 2961733.4492215198 5491871.325863583 1.0 0.5612730449627894 1.0407551504749666 22.331235694882302 -6.666048007867107 1.9516862030378879 0.71900831048476 1.0387734052733688 0.26150207862351926 0.1865346723496677 0.4702755600490121 3.449662149638483 0.07705480206104173 0.20691507306271514 2.157505900523359e-07 6.666048007867107 0.3197650947886088 YVFGYQK(ub)NSNIQAK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVFGYQKNSNIQAK 14 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 22367100.0 4282200.0 5194900.0 12890000.0 True False 4146263.904957775 7269250.66104562 9513722.308288913 1.0 1.7532050124338743 2.294528888263276 21.983380514584077 -7.569132944851632 0.12746030717063703 2.9587299253317364e-19 3.738855651834636 0.9999906538590527 0.0016228560635244093 0.13819814240856118 0.012774960559463583 0.14040464594558635 0.21269983713177842 2.6969137353784273e-08 7.569132944851632 3.738855651834636 YVFGYQK(ub)NSNIQAK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVFGYQKNSNIQAK 14 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 81563500.0 4148500.0 20990000.0 56425000.0 True False 6293577.795974878 17244170.50438148 45272574.018043905 1.0 2.739963032698216 7.193455850660723 22.5854489681569 -6.954955563458009 0.5015023494629556 0.9119600752291626 9.214031982579337 0.9995349602853857 0.056243236389973375 0.08155482899637154 0.028184013724835668 0.06577393147224114 0.3673926365887268 1.109288310636935e-07 6.954955563458009 8.302071907350175 YVFGYQK(ub)NSNIQAK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVFGYQKNSNIQAK 14 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 19306700.0 4282200.0 5646600.0 9377900.0 True False 3560839.033625354 5616180.645037653 11338775.531489495 1.0 1.5772071110217298 3.1842988195805315 21.763785790018353 -6.953115308541517 0.5235260218673231 0.9734166203915282 3.8602418193348678 0.9994236340823467 0.02218750064964815 0.08225837282130304 0.030967831997786407 0.024996833149347968 0.13279527963371437 1.1139987190531713e-07 6.953115308541517 2.8868251989433396 YVFGYQK(ub)NSNIQAK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVFGYQKNSNIQAK 14 1 Q8NEM2 Q8NEM2 SHCBP1 SHC SH2 domain-binding protein 1 1 50825500.0 4148500.0 18880000.0 27797000.0 True False 5370315.029160475 17829311.40314615 22738231.221305605 1.0 3.3199749560936564 4.2340591004137424 22.35657529024935 -9.248793545869695 0.3119431539067997 4.9617036837276964e-26 4.580333167929892 0.9985548602571924 0.05174784435746189 0.6542481476776728 0.11763676460534965 1.0402914987388372 0.3026173579061615 5.639056605785882e-10 9.248793545869695 4.580333167929892 YVIGQK(ub)GSGIR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVIGQKGSGIR 11 1 A0A024R4E5;Q00341;Q00341-2;H0Y394 A0A024R4E5 HDLBP Vigilin 1 3915000.0 1015800.0 1136100.0 1763100.0 True False 983553.9850208074 1589750.6546832332 1301291.2181337606 1.0 1.6163328895969056 1.323050120229274 19.907644715333426 -10.004783428288805 4.386904199713118 0.999980552408622 1.4696915047354997 0.7737415237546256 0.11973218952526764 83210878.82220136 108648483.95693551 21981.168293603474 0.04381749311474012 9.890461841029599e-11 10.004783428288805 0.46971095232687765 YVIHTVGPIAYGEPSASQAAELR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVIHTVGPIAYGEPSASQAAELR 23 0 Q9BQ69 Q9BQ69 MACROD1 O-acetyl-ADP-ribose deacetylase MACROD1 0 5810100.0 1724500.0 1849700.0 2235900.0 False True 2260836.200081756 1573731.9700741293 2004550.5162672633 1.0 0.696084028563069 0.8866411977102876 21.108425040453813 -10.402427687653445 5.800897988129634 1.0000712742925453 0.7913626139773408 0.615140668212949 0.0777946385399862 7.173497257424587e-05 7.38961381209307e-06 0.07534999916481125 0.025108111624132526 3.9588797680692625e-11 10.402427687653445 -0.20870866031520452 YVIHTVGPIAYGEPSASQAAELR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVIHTVGPIAYGEPSASQAAELR 23 0 Q9BQ69 Q9BQ69 MACROD1 O-acetyl-ADP-ribose deacetylase MACROD1 0 7532500.0 1724500.0 3300000.0 2508000.0 False True 2362094.2528601955 3154195.0883593177 1915662.0538813632 1.0 1.335338369559127 0.8110015303418737 21.171635101976705 -6.733965158310792 1.7087172606844319 1.200912646575388 0.811079500166743 0.5775182960674041 0.14093047351079444 0.3288819464905059 1.8829140963752597 0.06531219714742911 0.16134877749668722 1.8451634432395716e-07 6.733965158310792 -0.3898331464086451 YVIYIER ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVIYIER 7 0 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 47143800.0 15606000.0 7930800.0 23607000.0 False True 15110596.0722925 11097609.798575636 17423618.505180456 1.0 0.7344256801970067 1.153072878251919 23.849057236268138 -6.735311013332596 1.7039665774060826 0.8411287770087239 1.153070108326503 0.5836364889262113 0.11160251460865955 0.32638270997040547 1.8588254739690906 0.05185466907574371 0.12790248197173307 1.8394542327376176e-07 6.735311013332596 0.311941331317779 YVIYIER ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVIYIER 7 0 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 40891000.0 11175000.0 19373000.0 10343000.0 False True 16953292.001933042 15915736.78806013 8298701.516502065 1.0 0.938799189340064 0.4895038388742336 24.015062108293925 -6.931731002358667 0.7324426055697802 1.0064125848682528 0.39306325850644047 0.9968676753597991 0.012738159640263704 0.09174889893626027 0.0733492368273979 0.011726939523998 0.04027348012056415 1.1702239915816966e-07 6.931731002358667 -0.6133493263618124 down YVIYIER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVIYIER 7 0 P61254;J3QRI7;J3QQQ9;J3QQV1;E5RIT6;J3QRC4;Q9UNX3;J3KS10 P61254 RPL26;RPL26L1 60S ribosomal protein L26;60S ribosomal protein L26-like 1 0 41083000.0 11175000.0 19217000.0 10691000.0 False True 14466257.792182302 18147557.056899354 8745347.69892355 1.0 1.254474883387358 0.6045342081246207 23.786188430386375 -6.800517202420984 1.4538211770883285 1.1403172492685614 0.5954512514030345 0.8336409223639754 0.10906893858938699 0.22003606969999584 0.9181070058232839 0.05901800663769308 0.1372098061782929 1.5830068625024194e-07 6.800517202420984 -0.5448659978655269 YVK(ub)ENCKPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVKENCKPLK 10 2 P49761-1;P49761;P49761-3;H3BRW2;H3BNQ5 P49761-1 CLK3 Dual specificity protein kinase CLK3 1 23504250.0 392150.0 351100.0 22761000.0 True False 507645.9054321511 331560.97635829524 18618731.54758198 1.0 0.6531343458311606 36.676611292141004 18.953463009622155 -6.902169767009665 0.9481599783421963 5.312882052157865e-11 40.61862050673543 0.9888746057019404 1.7826102077195545 0.10614974780373485 0.16323087309715198 1.4262708150053574 3.7499580402690835 1.2526514140453154e-07 6.902169767009665 40.618620506682305 up YVK(ub)PTEPVTDYR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVKPTEPVTDYR 12 1 Q9GZR2 Q9GZR2 REXO4 RNA exonuclease 4 1 4056880.0 971180.0 1117600.0 1968100.0 True False 940350.4224970539 1563863.5082070064 1452595.5682655852 1.0 1.6630646095252921 1.544738571402233 19.84283895313096 -10.176781390973451 4.4722272892745005 0.9998751106266903 1.6039015904521792 0.9720126682587225 0.04830640282876924 5425068.0612718025 12523158.744823506 4038.546978666104 0.016536567559071694 6.656081163099354e-11 10.176781390973451 0.6040264798254888 YVK(ub)PTEPVTDYR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVKPTEPVTDYR 12 1 Q9GZR2 Q9GZR2 REXO4 RNA exonuclease 4 1 4065180.0 971180.0 1732200.0 1361800.0 True False 807579.2005689283 1722868.2947852213 1646546.0837482172 1.0 2.1333737837372295 2.0388663831216163 19.623244228565238 -10.597935311594842 6.186475954451281 0.9964639832668458 2.086120083429422 0.9943535168676025 0.03858248473750754 0.0018830263686148005 0.00012237940163749276 0.037383724912014006 0.012452443403639052 2.5238566743429407e-11 10.597935311594842 1.089656100162576 YVK(ub)TFNMDEYVGLPR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVKTFNMDEYVGLPR 15 1 D6RAY7;D6R9P4;P46926;D6RB13;D6R917;D6RFF8;Q8TDQ7-3;Q8TDQ7-2;Q8TDQ7 D6RAY7 GNPDA1;GNPDA2 Glucosamine-6-phosphate isomerase;Glucosamine-6-phosphate isomerase 1;Glucosamine-6-phosphate isomerase 2 1 8370700.0 2917900.0 2786000.0 2666800.0 True False 2426363.134887535 2770991.2650222983 3224415.5501099606 1.0 1.1420348525657669 1.3289088940346994 21.210364052880692 -6.967344157647387 0.31523706359202286 0.9729342580381394 1.503995080989673 0.9999536320418799 0.0009171522930939468 0.07717422870439018 0.012100390759207344 0.0028893931976322887 0.01650881915886077 1.0780920471415249e-07 6.967344157647387 0.5310608229515336 YVK(ub)TFNMDEYVGLPR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVKTFNMDEYVGLPR 15 1 D6RAY7;D6R9P4;P46926;D6RB13;D6R917;D6RFF8;Q8TDQ7-3;Q8TDQ7-2;Q8TDQ7 D6RAY7 GNPDA1;GNPDA2 Glucosamine-6-phosphate isomerase;Glucosamine-6-phosphate isomerase 1;Glucosamine-6-phosphate isomerase 2 1 27905600.0 5559500.0 9134100.0 13212000.0 True False 7196882.344128642 8625779.305480799 10807551.566567937 1.0 1.198543882340647 1.5016990760429687 22.778940642442606 -6.964960369792545 0.35873444266919463 0.9734965297903835 1.7371147636375555 0.9999123223480277 0.0019316776541183482 0.07797443213594166 0.014907558856578502 0.004077894087887179 0.02591300688028449 1.0840258289515997e-07 6.964960369792545 0.763618233847172 YVLGMQELFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVLGMQELFR 10 0 Q96J01;Q96J01-2;D6RGZ2 Q96J01 THOC3 THO complex subunit 3 0 10166100.0 2345200.0 3646800.0 4174100.0 False True 3074579.910949103 3102711.6551150656 3742204.1727944887 1.0 1.0091497846797803 1.2171432459660136 21.55195787350207 -6.916119169080899 0.8530256765777249 0.9947380216819719 1.2478613484688958 0.9930329048829082 0.008369888157962713 0.10050941277152185 0.11784892149772466 0.0070670344259792465 0.020443332994521526 1.2130559459422696e-07 6.916119169080899 0.25312332678692395 YVLGMQELFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVLGMQELFR 10 0 Q96J01;Q96J01-2;D6RGZ2 Q96J01 THOC3 THO complex subunit 3 0 11067700.0 3974800.0 2752800.0 4340100.0 False True 3848622.149695521 3852007.3956623594 3203297.609790898 1.0 1.0008795994605773 0.8323232276892453 21.875910606407157 -6.905725915241755 0.9243636012933099 1.005950133948215 0.812420789914819 0.9892058796818604 0.008233836691838248 0.10731226294174383 0.15460593500330644 0.006601818451364585 0.017726692667374783 1.2424361660047536e-07 6.905725915241755 -0.19352934403339606 YVLGMQELFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVLGMQELFR 10 0 Q96J01;Q96J01-2;D6RGZ2 Q96J01 THOC3 THO complex subunit 3 0 14327900.0 2345200.0 4841500.0 7141200.0 False True 3212283.8166469843 4627586.521300486 5454595.637630617 1.0 1.4405908025059908 1.6980428719789094 21.61516793502496 -9.879004001853907 0.11000449778790271 4.180818970026768e-18 2.3295942946219825 0.9999070027670025 0.0027794991347135163 1.4463074975772536 0.04999148143396003 0.7443608727245031 0.33355661106422796 1.3212834590198274e-10 9.879004001853907 2.3295942946219825 YVLGMQELFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVLGMQELFR 10 0 Q96J01;Q96J01-2;D6RGZ2 Q96J01 THOC3 THO complex subunit 3 0 7093300.0 3974800.0 1569700.0 1548800.0 False True 3305222.3134963466 1561243.714538946 1872646.9191579078 1.0 0.47235664244545883 0.5665721520489723 21.656315881841433 -10.064514822130757 5.2799267749533385 1.0000055262708683 0.519464397246614 0.9719772321864709 0.038463320733283006 2.5021596822393144e-06 4.432918112508525e-07 0.03724237840842963 0.012413983386297475 8.619561603146255e-11 10.064514822130757 -0.4805411290242543 YVLGYK(ub)QTLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVLGYKQTLK 10 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 69976300.0 30840000.0 31685000.0 7451300.0 True False 40431538.65498483 26957721.507162638 6680310.9539166605 1.0 0.6667498295625462 0.16522524682827128 25.268977771795356 -7.376068720814543 0.47069698179510183 1.017103770159832 8.91804097908733e-23 0.9984986947735341 0.013293815212013399 0.1084557657461349 0.05038074634923422 0.016054072174976217 0.060435037089201255 4.206600597532004e-08 7.376068720814543 -1.017103770159832 down YVLGYK(ub)QTLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVLGYKQTLK 10 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 74948200.0 41620000.0 27576000.0 5752200.0 True False 40298795.88163622 38587240.60694029 4245526.257698953 1.0 0.9575283767851768 0.10535119387112009 25.26423339622669 -6.944399416099742 0.8728116969475969 1.0186481216822363 5.24314693397444e-21 0.993359073449884 0.033582458252858514 0.09288798653910947 0.11763188347815468 0.028529539044812178 0.07639402162518741 1.136581502860258e-07 6.944399416099742 -1.0186481216822363 down YVLGYK(ub)QTLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVLGYKQTLK 10 1 P62888;E5RI99;E5RJH3;A0A0C4DH44 P62888 RPL30 60S ribosomal protein L30 1 63650000.0 30840000.0 28857000.0 3953000.0 True False 42242381.41966276 27582002.322662067 3019382.814590526 1.0 0.6529461975319257 0.07147757093981164 25.332187833318248 -7.48434058055515 0.5895151289359163 1.002652064917548 6.154722812260185e-20 0.9943590808062747 0.028771118938271355 0.11461667875102514 0.09316827448713189 0.027722815701239446 0.07047622892804825 3.2783809649212445e-08 7.48434058055515 -1.002652064917548 down YVLQGFFR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVLQGFFR 8 0 Q9BZE9;Q9BZE9-2;J3KRY8;Q9BZE9-3;J3KRF7 Q9BZE9 ASPSCR1 Tether containing UBX domain for GLUT4 0 7371700.0 1995400.0 3309200.0 2067100.0 False True 2615988.7234810903 2815480.259160568 1853216.3210233294 1.0 1.0762585610132198 0.7084190785643979 21.31892489127142 -6.852623257183095 1.2223017632935 1.0408058015837978 0.692947775865091 0.9440447205344035 0.03749631839826492 0.15459440086457893 0.4431316389429396 0.023986875896758957 0.055610403003422806 1.4040311487322112e-07 6.852623257183095 -0.3478580257187067 YVLQGFFR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVLQGFFR 8 0 Q9BZE9;Q9BZE9-2;J3KRY8;Q9BZE9-3;J3KRF7 Q9BZE9 ASPSCR1 Tether containing UBX domain for GLUT4 0 6868500.0 2441800.0 1052700.0 3374000.0 False True 2364286.3955737446 1473048.5997579775 2490248.1821696516 1.0 0.6230415242906775 1.0532768732382525 21.172973374910597 -6.6752016007091495 1.918587675581715 0.7604824066299852 1.051598207770805 0.3024864908035667 0.1599327508718755 0.44925431304030433 3.192820487715782 0.06698718231389734 0.17779035870471513 2.1125081800092868e-07 6.6752016007091495 0.2911158011408198 YVLQGFFR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVLQGFFR 8 0 Q9BZE9;Q9BZE9-2;J3KRY8;Q9BZE9-3;J3KRF7 Q9BZE9 ASPSCR1 Tether containing UBX domain for GLUT4 0 6857800.0 1995400.0 2328800.0 2533600.0 False True 2733153.3036574307 2225905.915688234 1935215.8611299153 1.0 0.8144094634975607 0.7080524383832633 21.38213495279431 -13.999999948577829 0.06316442314302986 2.142683819677304 0.2611246406654984 0.9999456844974831 0.0008890966513044951 12.431388168088244 0.06547065539181737 2.192828483090976 0.4164856423436383 1.0000001184039324e-14 13.999999948577829 -1.8815591790118058 YVLQGFFR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVLQGFFR 8 0 Q9BZE9;Q9BZE9-2;J3KRY8;Q9BZE9-3;J3KRF7 Q9BZE9 ASPSCR1 Tether containing UBX domain for GLUT4 0 5476000.0 2441800.0 1155800.0 1878400.0 False True 2030464.8900813565 1149573.4759916621 2271164.7552596936 1.0 0.5661626958472555 1.1185442143590538 20.953378650344874 -6.697266639947488 1.8408382189330452 0.7298840902383201 1.1168080762705659 0.4045430512430829 0.18322136446371037 0.40122058436112323 2.6413778981747362 0.07946657372775773 0.2050426388180019 2.0078596862229051e-07 6.697266639947488 0.38692398603224576 YVLSSYLR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVLSSYLR 8 0 E5RH56;E5RFF9;Q9BRT9-2;Q9BRT9 E5RH56 GINS4 DNA replication complex GINS protein SLD5;DNA replication complex GINS protein SLD5;DNA replication complex GINS protein SLD5, N-terminally processed 0 8284900.0 2171500.0 2642900.0 3470500.0 False True 2846857.5288359146 2248589.6219435125 3111405.951386709 1.0 0.7898497199692901 1.0929264706333826 21.440938864446853 -6.720216149849684 1.7586790910105639 0.8721754096466248 1.09245507078696 0.5134714592075615 0.08842969118172973 0.35489884366155666 2.14538277529403 0.0399239335129143 0.10019317732220644 1.90451259960438e-07 6.720216149849684 0.22027966114033526 YVLSSYLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVLSSYLR 8 0 E5RH56;E5RFF9;Q9BRT9-2;Q9BRT9 E5RH56 GINS4 DNA replication complex GINS protein SLD5;DNA replication complex GINS protein SLD5;DNA replication complex GINS protein SLD5, N-terminally processed 0 5417840.0 2978200.0 1634800.0 804840.0 False True 2476505.2566304733 1625993.0079176053 973128.3228402964 1.0 0.6565675576759838 0.39294417818613164 21.239874252564487 -7.669709614400038 0.1929981476116713 1.2273300917414287 4.445346006530911e-12 0.9999299525739043 0.0020801511694555643 0.13268700191360863 0.023122014405755426 0.046790094286690564 0.08071368989449305 2.1393920892661418e-08 7.669709614400038 -1.2273300917369834 down YVLVAGITPTPLGEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVLVAGITPTPLGEGK 16 0 A0A087WVM4;B7ZM99;Q6UB35 A0A087WVM4 MTHFD1L Monofunctional C1-tetrahydrofolate synthase, mitochondrial 0 7631700.0 1978700.0 3176900.0 2476100.0 False True 2594094.8617580608 2702918.903459208 2219896.924428363 1.0 1.0419506793315165 0.8557500950153775 21.306799806849632 -6.847521431746144 1.2469551661242297 1.022347707313585 0.8486532953488117 0.9366288768747482 0.020075610014205887 0.16020121853315725 0.480589568642535 0.012605582333722951 0.029128258091217028 1.4206221056751778e-07 6.847521431746144 -0.1736944119647732 YVLVAGITPTPLGEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVLVAGITPTPLGEGK 16 0 A0A087WVM4;B7ZM99;Q6UB35 A0A087WVM4 MTHFD1L Monofunctional C1-tetrahydrofolate synthase, mitochondrial 0 5861200.0 1794500.0 1393400.0 2673300.0 False True 1737534.5797596385 1949791.8864850048 1973082.5327190643 1.0 1.1221600474591584 1.1355644691641247 20.72861025942007 -13.72792715302068 0.31486877786672063 2.015210365055843e-11 1.1384089446485215 0.9996713607878507 0.001105677218427378 14.848053677618354 0.17805708717894125 9.681572712717022 0.004557075843895308 1.870995948112678e-14 13.72792715302068 1.1384089446283694 YVLVAGITPTPLGEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVLVAGITPTPLGEGK 16 0 A0A087WVM4;B7ZM99;Q6UB35 A0A087WVM4 MTHFD1L Monofunctional C1-tetrahydrofolate synthase, mitochondrial 0 9268100.0 1978700.0 2838500.0 4450900.0 False True 2710278.8623569 2713085.684335731 3399689.089162903 1.0 1.0010356211007714 1.2543687427818706 21.370009868372524 -6.907794748078764 0.9105981894615872 0.9915986994105787 1.285611694343304 0.9900628996245422 0.011929026525107196 0.10589528058654836 0.14680252201070645 0.009661172728076985 0.02627955141179222 1.2365316926310104e-07 6.907794748078764 0.29401299493272537 YVMTTTTLER ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVMTTTTLER 10 0 P05198;H0YJS4;G3V4T5 P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 0 13888800.0 3948600.0 5592900.0 4347300.0 False True 5176652.838296796 4758461.120953451 3897483.098246204 1.0 0.9192158078962589 0.7528963637299928 22.30358813935585 -6.959474032815807 0.44278446310335784 1.0057771463683756 0.6598204036936329 0.9997501879408037 0.0016259667746202453 0.07988955183645219 0.02182962635663786 0.0022006413603694037 0.013773561842036904 1.0978069280003563e-07 6.959474032815807 -0.34595674267474263 YVMTTTTLER ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVMTTTTLER 10 0 P05198;H0YJS4;G3V4T5 P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 0 13332500.0 5116900.0 1220100.0 6995500.0 False True 4954466.8103494495 1707292.292737444 5163168.689498462 1.0 0.3445965747860212 1.0421239836975096 22.240298375181002 -11.841740382926758 14.120183418005004 0.927130183945992 0.7240242513217233 0.0 0.32726921401053377 0.0 0.0 0.0 0.09493511664186094 1.4396589353683838e-12 11.841740382926758 -0.20310593262426868 YVMTTTTLER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVMTTTTLER 10 0 P05198;H0YJS4;G3V4T5 P05198 EIF2S1 Eukaryotic translation initiation factor 2 subunit 1 0 13745900.0 3948600.0 5204000.0 4593300.0 False True 5408504.126902738 4974070.072673291 3508457.1419829656 1.0 0.9196757469281562 0.6486926994344622 22.36679820087874 -6.948787447619578 0.5720098588800131 1.0033457089910887 0.5518023972907252 0.9991025889517684 0.004502393439532898 0.08397653143826798 0.03800724721943337 0.004759146564125459 0.022589427491849175 1.1251555127801257e-07 6.948787447619578 -0.45154331170036344 YVNSIWDLLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVNSIWDLLK 10 0 Q13618;Q13618-2;H7C1L6 Q13618 CUL3 Cullin-3 0 9572700.0 2124700.0 2937400.0 4510600.0 False True 2785502.2756240685 2499151.369895523 4043886.3807304157 1.0 0.8971995434236754 1.45176200935769 21.409506063932994 -6.858822180102678 1.191623955273827 0.9443867104069036 1.4780245053012029 0.9521937235600337 0.05266694514898711 0.14802548575536653 0.40006765679212564 0.034487113004442196 0.08040207738801455 1.384132989913465e-07 6.858822180102678 0.5336377948942993 YVNSIWDLLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVNSIWDLLK 10 0 Q13618;Q13618-2;H7C1L6 Q13618 CUL3 Cullin-3 0 16401400.0 6657500.0 4497200.0 5246700.0 False True 6446161.30663126 6292955.412588188 3872431.8723738925 1.0 0.976233003371252 0.6007345594020841 22.62000885970197 -6.919806065475042 0.8261830000636854 1.008343371948847 0.5404552034417138 0.9941264237495471 0.014015111456779222 0.0982860917336001 0.10621305485671027 0.012063023067714479 0.03606672714444639 1.2028014265859628e-07 6.919806065475042 -0.4678881685071332 YVNSIWDLLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVNSIWDLLK 10 0 Q13618;Q13618-2;H7C1L6 Q13618 CUL3 Cullin-3 0 18854100.0 2124700.0 4625400.0 12104000.0 False True 2910259.0078585423 4421034.533847626 9245284.489704963 1.0 1.5191206424959265 3.176790953911668 21.472716125455886 -6.950039410289261 0.5584095017217003 0.9781367482359196 3.7967817604487175 0.9992043815825691 0.0261844693056356 0.08346989542649483 0.03589671287031656 0.028122479119442056 0.13775022231909592 1.1219166407459522e-07 6.950039410289261 2.818645012212798 YVNSIWDLLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVNSIWDLLK 10 0 Q13618;Q13618-2;H7C1L6 Q13618 CUL3 Cullin-3 0 12716600.0 6657500.0 2612600.0 3446500.0 False True 5536006.227257201 2598525.4052395 4167147.2151844837 1.0 0.46938628653366454 0.7527352831842975 22.400414135136245 -10.059996897703336 5.2263576408658015 1.000004754330157 0.6110607848582064 0.7152803457569581 0.1156767434899915 6.408321744678191e-06 1.152524519560404e-06 0.11200489346724182 0.03733450842296198 8.709698115343025e-11 10.059996897703336 -0.38894396947195053 YVPK(ub)YVPLADVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVPKYVPLADVK 12 1 G5E972;P42167;P42167-2;H0YJH7 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 7282300.0 2742300.0 3426400.0 1113600.0 True False 3756202.41787098 3275010.318410412 850590.6153119176 1.0 0.8718939913431746 0.22644962136892327 21.840843379757285 -6.939635010112676 0.6629517539084733 1.0072923254704422 0.05424768891007779 0.9981156824690619 0.014694917980386874 0.08793358663213711 0.05537120390631647 0.014265129591316714 0.05564206110870797 1.1491189586652935e-07 6.939635010112676 -0.9530446365603644 down YVPLADVK(ub)SEK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVPLADVKSEK 11 1 G5E972;P42167;P42167-2 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 9921200.0 3334200.0 2730200.0 3856800.0 True False 3228357.646048807 3820383.0978049124 2846588.3784801164 1.0 1.1833828579930374 0.8817450513774585 21.622368982388274 -6.7421498616460385 1.678939894625551 1.1088390579768452 0.8814876062649336 0.6145295578671279 0.07704671615350717 0.3139287008371457 1.7383564286212112 0.03629265594795941 0.08884567334989456 1.810715162785297e-07 6.7421498616460385 -0.22735145171191162 YVPLADVK(ub)SEK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVPLADVKSEK 11 1 G5E972;P42167;P42167-2 G5E972 TMPO Lamina-associated polypeptide 2, isoforms beta/gamma;Thymopoietin;Thymopentin 1 16633700.0 4873300.0 5171900.0 6588500.0 True False 6308582.917104429 4884079.218534514 5389460.603718808 1.0 0.7741959300070916 0.8543060580382309 22.58888454155809 -10.758832928310285 9.725107378554416 1.000838592215292 0.8142509952519978 0.8775756773500862 0.03270482281755381 0.0005971214384449505 1.4807640517979809e-05 0.03179808642431059 0.010555436176087531 1.7424770697939526e-11 10.758832928310285 -0.1865875969632942 YVPVSCEK(ub)EVDALLHLAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVPVSCEKEVDALLHLAR 18 1 Q9BW19 Q9BW19 KIFC1 Kinesin-like protein KIFC1 1 90380000.0 67756000.0 12662000.0 9962000.0 True False 87711477.67043445 11957348.569207454 8149018.218751877 1.0 0.13632592776666907 0.09290709078429682 26.38626230613756 -13.299164429919665 0.43327268157394994 9.99820186727761 0.09214263588126284 0.9998687242848806 0.0047863929523679575 17.18128906730655 0.22073829710811335 143.8471925908151 0.010196471251984904 5.0215243164502014e-14 13.299164429919665 -9.906059231396346 YVQFLSGLLSGSVK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVQFLSGLLSGSVK 14 0 Q68CZ2;Q68CZ2-2;E9PCX8;Q68CZ2-3;C9JHU5;Q68CZ2-4 Q68CZ2 TNS3 Tensin-3 0 5725210.0 1811600.0 2954300.0 959310.0 False True 2375025.1435593534 2513529.955771204 860049.8035512991 1.0 1.0583171982778588 0.3621223993706347 21.179511356155707 -6.886561377207742 1.0425488847010926 1.0405490415037262 0.30613514383073326 0.9786030598026608 0.04612753587733549 0.12197580768811463 0.23852041553044528 0.03385624275949857 0.08342114435872271 1.2984900401413926e-07 6.886561377207742 -0.7344138976729929 down YVQFLSGLLSGSVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVQFLSGLLSGSVK 14 0 Q68CZ2;Q68CZ2-2;E9PCX8;Q68CZ2-3;C9JHU5;Q68CZ2-4 Q68CZ2 TNS3 Tensin-3 0 21147800.0 7354400.0 8018600.0 5774800.0 False True 7120938.597595029 11220468.796446579 4262206.639713482 1.0 1.5757008212704002 0.598545624470483 22.763635981983608 -6.747019448443951 1.6606207619700306 1.3397144895809068 0.5970037914942834 0.6361954748741219 0.24188641499175093 0.3052505897817992 1.6551970673439105 0.11510641876742912 0.28035527497130514 1.7905256694616846e-07 6.747019448443951 -0.7427106980866234 YVQFLSGLLSGSVK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVQFLSGLLSGSVK 14 0 Q68CZ2;Q68CZ2-2;E9PCX8;Q68CZ2-3;C9JHU5;Q68CZ2-4 Q68CZ2 TNS3 Tensin-3 0 14420700.0 5978500.0 0.0 8442200.0 False True 9069821.58689545 0.0 6773595.469652301 1.0 0.0 0.746827862572197 23.11264274100049 -10.742636644240633 9.424841340017457 1.002351645958872 0.3734139325078139 0.4841515412832268 0.30489119816588023 0.015083068101803284 0.00041187176779252326 0.2955474880852666 0.09840321107513997 1.8086867445802438e-11 10.742636644240633 -0.6289377134510581 YVQFLSGLLSGSVK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVQFLSGLLSGSVK 14 0 Q68CZ2;Q68CZ2-2;E9PCX8;Q68CZ2-3;C9JHU5;Q68CZ2-4 Q68CZ2 TNS3 Tensin-3 0 17347700.0 1811600.0 6012700.0 9523400.0 False True 2481397.4766491884 5747039.032660014 7274169.060579667 1.0 2.316049357969308 2.9314808002474906 21.2427214176786 -9.368402673020181 0.2304461636383155 6.248053788144786e-20 3.3939979537770655 0.9992645301768869 0.021848324622104065 0.7856250725308294 0.08842431686613024 0.8731759164787727 0.2948374114979879 4.281513591191651e-10 9.368402673020181 3.3939979537770655 YVQFLSGLLSGSVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVQFLSGLLSGSVK 14 0 Q68CZ2;Q68CZ2-2;E9PCX8;Q68CZ2-3;C9JHU5;Q68CZ2-4 Q68CZ2 TNS3 Tensin-3 0 17084500.0 7354400.0 4020500.0 5709600.0 False True 6115509.455161897 3998840.76849323 6903450.961792343 1.0 0.6538851420003843 1.128843150747706 22.544041257417884 -6.711298928207585 1.790405219909188 0.7874988677178884 1.1277780524172218 0.4713089256761802 0.14582188890086875 0.37249019785138854 2.3283279279977696 0.06479220051023342 0.16435434240559882 1.9440215361447012e-07 6.711298928207585 0.3402791846993335 YVQFLSGLLSGSVK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVQFLSGLLSGSVK 14 0 Q68CZ2;Q68CZ2-2;E9PCX8;Q68CZ2-3;C9JHU5;Q68CZ2-4 Q68CZ2 TNS3 Tensin-3 0 14063300.0 5978500.0 5338200.0 2746600.0 False True 7739286.10385341 5041124.477345073 2246746.982495877 1.0 0.6513681507180725 0.2903041640206602 22.883769063092938 -7.382314693471621 0.30415608674954814 1.078704979639217 1.9646051993803073e-12 0.9997920428792714 0.004178354905346723 0.11425755056733482 0.025540766776461093 0.016748644993528173 0.05593803235440201 4.146534723204179e-08 7.382314693471621 -1.0787049796372523 down YVQLK(ub)QER ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVQLKQER 8 1 B8ZZ06;Q4TT61;Q9BV90;H7BYR9 B8ZZ06 C16orf33;SNRNP25 U11/U12 small nuclear ribonucleoprotein 25 kDa protein 1 2048050.0 713110.0 499560.0 835380.0 True False 976766.0380731431 477487.7873759933 638080.4491911544 1.0 0.4888456076113466 0.6532582259410755 19.897653513464782 -10.414482762360901 5.181125162986796 1.0003969781817235 0.5710519167761958 0.9007508542023468 0.06712117036385362 0.0003080660989970771 3.48142811078166e-05 0.06504846537628642 0.021663264583088503 3.8505009744911076e-11 10.414482762360901 -0.42934506140552764 YVQLK(ub)QER ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVQLKQER 8 1 B8ZZ06;Q4TT61;Q9BV90;H7BYR9 B8ZZ06 C16orf33;SNRNP25 U11/U12 small nuclear ribonucleoprotein 25 kDa protein 1 2834270.0 854720.0 1838900.0 140650.0 True False 710737.5505161498 1828993.4807069271 170059.26470787666 1.0 2.5733739259712403 0.23927153501932844 19.43895739789865 -6.725113976781464 1.7407476025203885 1.951980283222957 0.2417956865245153 0.5365108490817352 0.6617064952289139 0.34552491068366603 2.048761225523022 0.30150290914542105 0.7524182186172418 1.883154807153769e-07 6.725113976781464 -1.7101845966984417 YVQLPADEVDTQLLQDAAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVQLPADEVDTQLLQDAAR 19 0 Q9Y333 Q9Y333 LSM2 U6 snRNA-associated Sm-like protein LSm2 0 8807600.0 2754800.0 0.0 6052800.0 False True 2667350.3819012837 0.0 4467390.0998922475 1.0 0.0 1.6748418693714688 21.34697591840844 -6.744996048944941 1.668435297226649 0.40846357421251683 1.6769244222429665 0.6271129232360324 0.4201438826880716 0.30886546831840406 1.6899741469437364 0.19906764995172616 0.48583531724870377 1.7988872806840884e-07 6.744996048944941 1.2684608480304496 YVRPFLNSISK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVRPFLNSISK 11 1 O00231;O00231-2;J3QRY4 O00231 PSMD11 26S proteasome non-ATPase regulatory subunit 11 0 37489000.0 0.0 13278000.0 24211000.0 False True 0.0 11296974.157238629 21705877.968311116 0.0 YVSHGATGK(ub)GNDQVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVSHGATGKGNDQVR 15 1 P00966;Q5T6L6 P00966 ASS1 Argininosuccinate synthase 1 55436100.0 13695000.0 29526100.0 12215000.0 True False 17954277.622568663 25120920.971836362 10951108.974553712 1.0 1.3991607738235692 0.6099442820683626 24.0978242725857 -6.76918904082621 1.5774257088467811 1.2291822251188138 0.6056259621238997 0.7275100230719014 0.16819203541289032 0.2677356036322111 1.3146236156340056 0.0840480570466017 0.20022923600381679 1.7014177496649373e-07 6.76918904082621 -0.6235562629949141 YVSHGATGK(ub)GNDQVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVSHGATGKGNDQVR 15 1 P00966;Q5T6L6 P00966 ASS1 Argininosuccinate synthase 1 84798300.0 25668800.0 28781500.0 30348000.0 True False 24853957.99439076 40274103.043539755 22398948.37951525 1.0 1.620430156542034 0.9012225893586214 24.56697228357182 -6.678484378626953 1.9069094128865383 1.3931008306792907 0.9039763164166056 0.3171453078791965 0.26304401648699094 0.44202787684522704 3.1062201337762283 0.11072966562978853 0.292649228154927 2.0966001926816595e-07 6.678484378626953 -0.4891245142626851 YVSHGATGK(ub)GNDQVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVSHGATGKGNDQVR 15 1 P00966;Q5T6L6 P00966 ASS1 Argininosuccinate synthase 1 138960100.0 38361000.0 20264100.0 80335000.0 True False 58196441.564756535 16647813.03086407 64456752.03791871 1.0 0.2860623877207279 1.1075720491637995 25.794427606110943 -6.676940644744741 1.9127917721490266 0.5470510028343575 1.1043738701514938 0.31018806595697834 0.30278764549528686 0.4453407414212868 3.1475744993195316 0.12714460552991036 0.3366511884663649 2.1040659839212777e-07 6.676940644744741 0.5573228673171363 YVSHGATGK(ub)GNDQVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVSHGATGKGNDQVR 15 1 P00966;Q5T6L6 P00966 ASS1 Argininosuccinate synthase 1 61885700.0 13695000.0 19928000.0 28262700.0 True False 18758411.5934592 19047515.06691651 21587632.34857768 1.0 1.015411937840095 1.1508241111472886 24.161034334108592 -6.9283945009571966 0.7598501969429675 0.9978135008817401 1.177520528267811 0.9962132876161173 0.0041696501355176436 0.09347998008929188 0.08182593249804306 0.0037630973821113117 0.012362390781817518 1.179248952225195e-07 6.9283945009571966 0.1797070273860708 YVSHGATGK(ub)GNDQVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVSHGATGKGNDQVR 15 1 P00966;Q5T6L6 P00966 ASS1 Argininosuccinate synthase 1 83388400.0 25668800.0 34255000.0 23464600.0 True False 21344744.52064884 34070461.51591489 28370939.371947706 1.0 1.5961990776209678 1.3291768071761996 24.347377559006095 -9.993252806604723 4.3214523508891585 0.9999801472316168 1.462687942252489 0.8001326455562614 0.10901138588550996 75672876.71035354 227306452.36146024 26349.616619886117 0.03989408193903125 1.0156572977902673e-10 9.993252806604723 0.4627077950208722 YVSHGATGK(ub)GNDQVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVSHGATGKGNDQVR 15 1 P00966;Q5T6L6 P00966 ASS1 Argininosuccinate synthase 1 93038400.0 38361000.0 20789400.0 33888000.0 True False 49659070.70835848 19632451.61464865 27720731.72024332 1.0 0.39534472422868294 0.5582209116043213 25.565553928203393 -10.608561142763778 9.902780288611023 1.0000695583061645 0.47678281791680055 0.9322448291986933 0.06649392505337619 0.00010212847885399797 4.036905486048736e-06 0.06439086350927889 0.021460822029640846 2.4628550772856236e-11 10.608561142763778 -0.523286740389364 YVSLHVR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVSLHVR 7 0 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 0 45111000.0 18179000.0 13754000.0 13178000.0 False True 23832845.045686428 11701956.81267208 11814466.972302001 1.0 0.4910012543714352 0.4957220570877808 24.50644784772897 -9.985788862610338 5.466967967961544 1.0000014455670587 0.493361655728789 0.9999348862849998 0.0019272596414451433 3.395706008782367e-08 6.301925167483405e-09 0.001866066460744638 0.0006220203741772492 1.0332636169796637e-10 9.985788862610338 -0.5066397898382697 YVSLHVR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVSLHVR 7 0 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 0 35656700.0 15150000.0 5530700.0 14976000.0 False True 14669071.542690724 7739137.352219487 11053336.329630315 1.0 0.5275819488436355 0.7535130152895021 23.806274224851666 -10.075738112970752 5.030073734682753 1.0000080637306132 0.6405474820650382 0.7714269934354229 0.09223597164451694 8.341141414757115e-06 1.5325591616328898e-06 0.08930909823722225 0.029769031840945048 8.39966347961434e-11 10.075738112970752 -0.35946058166557504 YVSLHVR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVSLHVR 7 0 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 0 61954000.0 21357000.0 22622000.0 17975000.0 False True 32400130.405842014 18584927.35350727 14422233.371277642 1.0 0.5736065602426171 0.4451288680207655 24.949496283972145 -13.999999999999998 0.16808699018695458 3.139758877379234 0.329457594712363 0.999517459421939 0.005209624333430687 12.073507067696237 0.12978923378903431 8.422216968005676 0.10659939575741827 1.0000000000000041e-14 13.999999999999998 -2.810301282666871 YVSLHVR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVSLHVR 7 0 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 0 50213000.0 18179000.0 14591000.0 17443000.0 False True 24900267.569002897 13946321.374015374 13323322.649861496 1.0 0.560087209318845 0.5350674490922755 24.569657909251863 -13.999999999999998 0.40824469238379285 8.819980291511612 0.5338778806261625 0.9998490981152122 0.002622900918963854 28.02697679254736 0.21158397418966743 194.72734672733944 0.006260331319069491 1.0000000000000041e-14 13.999999999999998 -8.28610241088545 YVSLHVR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVSLHVR 7 0 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 0 33889600.0 15150000.0 11807000.0 6932600.0 False True 12597896.258797826 11743393.34749398 8382174.607279251 1.0 0.9321709836507743 0.6653630443595298 23.586679500285943 -6.945260219512019 0.6086665211292427 1.0029570415372362 0.5807143545427018 0.9987748077249773 0.005055832771208778 0.08544682063851355 0.044283481072952546 0.005145643841982227 0.022487411412950718 1.1343309463522351e-07 6.945260219512019 -0.4222426869945344 YVSLHVR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVSLHVR 7 0 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 0 82842000.0 21357000.0 38423000.0 23062000.0 False True 27647057.50940831 36284726.27346845 18864952.636102792 1.0 1.3124263318481808 0.6823493831010059 24.720622606064595 -6.771890671491196 1.5673552840479357 1.1787655544349962 0.6785605462020871 0.7377041722349124 0.1317402954942836 0.26337607309682776 1.2771759517337353 0.06624400382074713 0.15740737174790628 1.6908665337594e-07 6.771890671491196 -0.5002050082329091 YVSPEQKK(ub) ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVSPEQKK 8 1 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4;A0A0G2JN56;H0Y7S4;Q5TYX0;Q5VWM5;A6NGN4;O60813;O60810 A3QJZ7;O60810 LOC101929983;PRAMEF25;PRAMEF6;PRAMEF26;PRAMEF5;PRAMEF9;PRAMEF11;PRAMEF4 PRAME family member 6;Putative PRAME family member 26;PRAME family member 5;PRAME family member 9/15;PRAME family member 25;PRAME family member 11;PRAME family member 4 1 3036030.0 314150.0 464480.0 2257400.0 True False 411853.69223292737 395181.3945288595 2023825.902509831 1.0 0.9595188825097659 4.913943812273119 18.6517723968517 -6.9045868773332915 0.9318051325961869 0.855633518877694 5.3699778341659 0.9887136405192226 0.19703466206248904 0.10810755967862007 0.15898653145881633 0.15711637822131408 0.41905332692634417 1.2456990196574882e-07 6.9045868773332915 4.514344315288207 up YVSPEQKK(ub) ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVSPEQKK 8 1 A3QJZ7;A0A1B0GU46;A0A0G2JP20;A0A096LNW4;Q5VXH4;A0A0G2JN56;H0Y7S4;Q5TYX0;Q5VWM5;A6NGN4;O60813;O60810 A3QJZ7;O60810 LOC101929983;PRAMEF25;PRAMEF6;PRAMEF26;PRAMEF5;PRAMEF9;PRAMEF11;PRAMEF4 PRAME family member 6;Putative PRAME family member 26;PRAME family member 5;PRAME family member 9/15;PRAME family member 25;PRAME family member 11;PRAME family member 4 1 3681430.0 314150.0 404980.0 2962300.0 True False 430299.7445845346 387086.64451022865 2262665.750483557 1.0 0.8995744231360646 5.258347881819494 18.714982458374593 -6.901626795018454 0.9509180520771116 0.826775250838835 5.731308439279897 0.9873584817760624 0.22840943219236243 0.11021840153463551 0.17074050775601804 0.17958235936082131 0.47117839350162505 1.254218507379862e-07 6.901626795018454 4.904533188441063 up YVSQYYPK(ub)LR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVSQYYPKLR 10 1 Q5SSJ5;Q5SWC8;Q5SSJ5-2;Q5SSJ5-3;B0QZK4 Q5SSJ5 HP1BP3 Heterochromatin protein 1-binding protein 3 1 5062000.0 1050400.0 1971400.0 2040200.0 True False 1017055.6269598894 2758590.3007151876 1505810.4153119507 1.0 2.712329815195035 1.4805585608065632 19.955967157609514 -10.458084014943438 5.544844570705212 0.9989157079543765 2.096444188000789 0.5137266728405889 0.5028685088466323 0.006745862548826351 0.0006592935247679507 0.4872875941764416 0.16230011334126215 3.4826993515786494e-11 10.458084014943438 1.0975284800464127 YVSSLTEEISK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVSSLTEEISKR 12 1 P49257 P49257 LMAN1 Protein ERGIC-53 1 2518100.0 1008400.0 1509700.0 0.0 True False 976388.8939702532 2112531.0829814943 0.0 1.0 2.163616460641404 0.0 19.89709635957517 -6.76459203893886 1.6209401760772888 1.675202380756508 2.709559854655361e-09 0.6933327449678794 0.4896118158896641 0.27893342250249786 1.4496724511151056 0.2392491285544275 0.5665282218764096 1.719522888453495e-07 6.76459203893886 -1.675202378046948 YVSSLTEEISK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVSSLTEEISKR 12 1 P49257 P49257 LMAN1 Protein ERGIC-53 1 6687000.0 1008400.0 2464700.0 3213900.0 True False 838529.279694504 2451422.171895356 3885911.6306053684 1.0 2.923478322412864 4.634199096805657 19.677501635009445 -7.1682577341572 0.2077924183787495 5.518408687987476e-18 7.271559581951619 0.999989192272135 0.004880315762205698 0.08832503464933023 0.009366554016131463 0.07905267303127327 0.2256748178332507 6.788006755222365e-08 7.1682577341572 7.271559581951619 YVVGLIIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVVGLIIK 8 0 O14980;C9JKM9;C9J673 O14980 XPO1 Exportin-1 0 37826000.0 11036000.0 12011000.0 14779000.0 False True 14468302.872776013 10219005.618511315 13249810.85017842 1.0 0.706302992712414 0.9157819660459042 23.78639236834623 -10.124173754908146 6.538007579418486 1.0000003549813328 0.8110424801558646 0.5203586862510383 0.08551943275152352 4.424651302431039e-07 5.935364999647378e-08 0.08280399078875729 0.027601278235312842 7.51322240773412e-11 10.124173754908146 -0.18895787482546822 YVVGLIIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVVGLIIK 8 0 O14980;C9JKM9;C9J673 O14980 XPO1 Exportin-1 0 26176200.0 10495000.0 6987200.0 8694000.0 False True 10161841.969672564 9777225.39776665 6416780.585590676 1.0 0.9621509000972677 0.6314584112546909 23.27665859778351 -6.9284943354655955 0.7590511117387128 1.0053198590460244 0.5661010951084444 0.9962339087537324 0.010158557876751325 0.09342733657662924 0.08156634796947725 0.009173346709617707 0.030173538484445213 1.1789779006377097e-07 6.9284943354655955 -0.43921876393757997 YVVGLIIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVVGLIIK 8 0 O14980;C9JKM9;C9J673 O14980 XPO1 Exportin-1 0 131299000.0 34327000.0 44350000.0 52622000.0 False True 52076568.6398529 36435395.99186842 42221238.63495809 1.0 0.6996504751272211 0.8107530841163607 25.634131055699783 -10.761680133090387 8.086139148589575 1.0028954805384245 0.7552017796217919 0.8661852313832307 0.04535745018589126 0.0023886964179165296 7.040108133757787e-05 0.044308063926699566 0.014639054099699117 1.7310908742012413e-11 10.761680133090387 -0.24769370091663256 YVVGLIIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVVGLIIK 8 0 O14980;C9JKM9;C9J673 O14980 XPO1 Exportin-1 0 58811000.0 11036000.0 16171000.0 31604000.0 False True 15116307.436686048 15456511.749654096 24139786.104811244 1.0 1.0225057815470462 1.5969366993837362 23.849602429869122 -6.9151655460779855 0.8598256926441319 0.9849851897722269 1.67999529942501 0.9927287329073144 0.02355604325159168 0.10110133238083674 0.12097637558184625 0.019792250652650323 0.0568031129939413 1.2157224984307715e-07 6.9151655460779855 0.6950101096527831 YVVGLIIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVVGLIIK 8 0 O14980;C9JKM9;C9J673 O14980 XPO1 Exportin-1 0 23267500.0 10495000.0 4366400.0 8406100.0 False True 8727057.507332236 4342877.336537463 10163776.64458503 1.0 0.4976336334312792 1.1646281276416137 23.057063873217785 -6.705218838049865 1.8123306453380956 0.6896547985426328 1.1628443349526825 0.44231412717047247 0.21186031335572397 0.38477844809444445 2.4605090479842295 0.09313651957111782 0.23798518642601368 1.971429096013951e-07 6.705218838049865 0.4731895364100497 YVVGLIIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVVGLIIK 8 0 O14980;C9JKM9;C9J673 O14980 XPO1 Exportin-1 0 100127000.0 34327000.0 35806000.0 29994000.0 False True 44436978.186330415 33813364.62399634 24535399.764429256 1.0 0.7609285330386826 0.5521392490179895 25.405257377792232 -6.972713694939981 0.18205805890213966 1.15706893867579 0.15034122785936596 0.9999965414253493 0.00034023900943421046 0.07543166987879549 0.005754877017993447 0.007895656458612486 0.023285978343440105 1.0648447770329412e-07 6.972713694939981 -1.006727710816424 YVVTSVSWWSHK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVVTSVSWWSHK 12 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 40936400.0 16686100.0 21704400.0 2545900.0 False True 21875638.68842226 18466188.123088583 2282474.6899972428 1.0 0.8441439532854355 0.10433865371918255 24.382821803175617 -7.075296873017867 0.7415137427166518 1.0008080521151999 1.2122662749209642e-19 0.9971228229179525 0.02095683601199068 0.0773108308640608 0.07042432789360943 0.01962214807788677 0.05376346879738439 8.408201811737292e-08 7.075296873017867 -1.0008080521151999 down YVVTSVSWWSHK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVVTSVSWWSHK 12 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 48349000.0 22971600.0 11315100.0 14062300.0 False True 22242379.132018086 15833278.43746697 10378961.770042766 1.0 0.7118518366893062 0.46663001778897684 24.40680777684077 -7.074600196391079 0.17991396115523106 1.1966548700052775 3.96075412488614e-13 0.9999964591547021 0.0004101396244629977 0.07409837266333924 0.006061430276399172 0.010521914097945645 0.028236411127690108 8.421700713628483e-08 7.074600196391079 -1.1966548700048814 down YVVTSVSWWSHK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVVTSVSWWSHK 12 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 169722000.0 45480000.0 46672000.0 77570000.0 False True 68996485.03337048 38343016.94999959 62238255.49986124 1.0 0.555724207275991 0.9020496546999374 26.040019531115494 -9.828867191272483 6.2862333453899675 1.000000011779758 0.7288869309878658 0.44967006164835943 0.14138677185531123 2.3452521614654184e-08 4.218591001456782e-09 0.13689715931203209 0.04563238439741879 1.482971513537757e-10 9.828867191272483 -0.2711130807918922 YVVTSVSWWSHK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVVTSVSWWSHK 12 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 60303200.0 16686100.0 20060300.0 23556800.0 False True 22855402.094897367 19173969.615458883 17993169.00752495 1.0 0.8389250618233319 0.7872611005842708 24.446031864698508 -13.999999999999998 0.15908217890059548 1.7917520513387042 0.7359550170187188 0.9995388083894432 0.001945619333706992 12.00367259054801 0.1260109875731093 2.9327176496149936 0.04670752216830885 1.0000000000000041e-14 13.999999999999998 -1.0557970343199854 YVVTSVSWWSHK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVVTSVSWWSHK 12 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 53329600.0 22971600.0 12648400.0 17709600.0 False True 19101903.21442904 12580260.55868917 21412595.48006125 1.0 0.6585867605687791 1.1209665989662632 24.187213052275045 -6.708884424762219 1.7990193885667256 0.7898671362930979 1.1198517293827166 0.45983285478085667 0.14389534056526634 0.3773444247613881 2.3799129914018704 0.06366603091250021 0.16197063478811888 1.954859617357653e-07 6.708884424762219 0.3299845930896187 YVVTSVSWWSHK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVVTSVSWWSHK 12 0 P55884;P55884-2 P55884 EIF3B Eukaryotic translation initiation factor 3 subunit B 0 195758000.0 45480000.0 81130000.0 69148000.0 False True 58874756.54482787 76615044.18099837 56563773.51839544 1.0 1.301322479739901 0.960747472056673 25.811145853207943 -6.673197201558227 1.9261584552683146 1.1918009881493405 0.962105994568241 0.2932801384983549 0.1279014656611058 0.45378953996057325 3.2488324854388932 0.05340163099522163 0.142077433400121 2.1222805720905888e-07 6.673197201558227 -0.22969499358109957 YVVVTGITPTPLGEGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVVVTGITPTPLGEGK 16 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 29655300.0 9091200.0 12495000.0 8069100.0 False True 11918651.239306023 10630794.70512854 7234186.93627272 1.0 0.8919461180363836 0.6069635557767976 23.506717648295137 -6.954305133943198 0.5093945026357546 1.0052710935917515 0.48114888924213783 0.9994972523758342 0.0037172802146350848 0.08180171888588487 0.02915422294622213 0.004286067055365632 0.023519350935813206 1.1109509023855493e-07 6.954305133943198 -0.5241222043496137 YVVVTGITPTPLGEGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVVVTGITPTPLGEGK 16 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 32915300.0 9359200.0 5511100.0 18045000.0 False True 9062097.318967074 7711710.970006825 13318473.161603821 1.0 0.8509852298613176 1.4696899285917073 23.111413553536465 -6.843101774618179 1.2679114051810112 0.920732295852218 1.4913220530075026 0.9296603115074104 0.06992470516281385 0.16520364281993827 0.514547937841557 0.04322088564872207 0.0996710777990204 1.4351530733998793e-07 6.843101774618179 0.5705897571552846 YVVVTGITPTPLGEGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVVVTGITPTPLGEGK 16 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 50164800.0 5102300.0 40119000.0 4943500.0 False True 7740562.128095128 32959450.99882231 3966415.0581869734 1.0 4.25801775806343 0.5124195106955453 22.884006909591452 -6.676756419566954 1.9131526510245649 3.067388031846545 0.5269495185554179 0.30934144058015256 1.3818229300318432 0.4458387884934756 3.152035938453074 0.5801277479123648 1.536581059206135 2.1049587057292285e-07 6.676756419566954 -2.5404385132911274 YVVVTGITPTPLGEGK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVVVTGITPTPLGEGK 16 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 34388200.0 9091200.0 11320000.0 13977000.0 False True 12452462.320442205 10819844.969765887 10675920.4653508 1.0 0.8688920063627752 0.8573340910917674 23.569927709818028 -13.999999999739408 0.34382378742481945 2.5522650726333262 0.8556042348560702 0.9997427596939819 0.001037711283317641 20.059863431265548 0.1883325204306944 22.67426249262401 0.00352293738931634 1.0000000006000343e-14 13.999999999739408 -1.696660837777256 YVVVTGITPTPLGEGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVVVTGITPTPLGEGK 16 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 21273000.0 9359200.0 6542600.0 5371200.0 False True 7782589.482860775 6507353.715195574 6494293.08637717 1.0 0.8361424856760604 0.8344643001765982 22.89181882897074 YVVVTGITPTPLGEGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVVVTGITPTPLGEGK 16 0 P11586;V9GYY3;A0A384N5Y3;F5H2F4;V9GZ78;A0A494C1T2 P11586 MTHFD1 C-1-tetrahydrofolate synthase, cytoplasmic;Methylenetetrahydrofolate dehydrogenase;Methenyltetrahydrofolate cyclohydrolase;Formyltetrahydrofolate synthetase;C-1-tetrahydrofolate synthase, cytoplasmic, N-terminally processed 0 20167400.0 5102300.0 10418000.0 4647100.0 False True 6605027.931369293 9838229.141841989 3801375.4832726214 1.0 1.48950606175596 0.5755275409538739 22.6551332316839 -6.761224176291589 1.6078013022172848 1.283905734642073 0.5719811702337124 0.6959323587250972 0.20592621001025302 0.28088465852834527 1.4313206455014817 0.1010405391210765 0.24252963314215137 1.7329092651033715e-07 6.761224176291589 -0.7119245644083606 YVWLVYEQDRPLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YVWLVYEQDRPLK 13 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 284768000.0 90082000.0 100668000.0 94018000.0 False True 118098374.35532907 85648726.80079058 84289919.24433829 1.0 0.7252320556343523 0.7137263294643716 26.815413865022396 YVWLVYEQDRPLK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YVWLVYEQDRPLK 13 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 298071000.0 130684000.0 67064000.0 100323000.0 False True 126535507.95280504 93843004.93413997 74045396.67451277 1.0 0.7416337631421319 0.5851748483289771 26.914967044881408 -10.595957606500068 0.07830862884154088 1.929506134241916 5.732271582427655e-13 0.999961272943626 0.0010644254887481296 2.593300855166693 0.043646076115127386 0.7906256540479225 0.343764331369967 2.535376108247548e-11 10.595957606500068 -1.9295061342413427 YVWLVYEQDRPLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YVWLVYEQDRPLK 13 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 399931000.0 111069000.0 161457000.0 127405000.0 False True 168499793.23156166 132643736.88070115 102223345.90640472 1.0 0.7872041522235868 0.6066674857334916 27.32817158015598 -6.973030576194294 0.17093758955429997 1.1575082525918978 0.23152429340003564 0.9999973969397649 0.0002593015062653577 0.07533106051456326 0.0053373173897294296 0.0075431239082623435 0.020851567116343957 1.064068100628822e-07 6.973030576194294 -0.9259839591918622 YVWLVYEQDRPLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YVWLVYEQDRPLK 13 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 305968000.0 90082000.0 92925000.0 122961000.0 False True 123387749.77451572 88819266.23811793 93920144.26128638 1.0 0.7198386095899327 0.7611788401435332 26.878623926545288 -10.305820427974611 6.374511995769628 1.0000097513886912 0.7405087248668727 0.9813201958114391 0.01687707845088958 2.339005502288927e-06 2.5469426418499175e-07 0.016341774735590342 0.005447053647744252 4.945151167657135e-11 10.305820427974611 -0.2595010265218185 YVWLVYEQDRPLK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YVWLVYEQDRPLK 13 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 216642200.0 130684000.0 39186200.0 46772000.0 False True 108669536.2828209 38975096.162748255 56551808.95070611 1.0 0.35865705786498014 0.5204016772789537 26.695372320315684 -10.466408569456755 9.281027319524545 1.0000062557043727 0.43952936757301714 0.9412102164291352 0.06603196436748286 8.547469528431497e-06 4.912994726291133e-07 0.06393588701417435 0.02131172485938523 3.4165787118720724e-11 10.466408569456755 -0.5604768881313555 YVWLVYEQDRPLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YVWLVYEQDRPLK 13 1 P30086 P30086 PEBP1 Phosphatidylethanolamine-binding protein 1;Hippocampal cholinergic neurostimulating peptide 0 378624000.0 111069000.0 172171000.0 95384000.0 False True 143781009.99730617 162589532.4995273 78025090.7224884 1.0 1.1308136763163197 0.5426661749277617 27.09929790224843 -6.84836011150786 1.243086375662973 1.0697193832144691 0.5199025341534758 0.9378637291901871 0.062852008962034 0.15927735143076346 0.4744723017916249 0.03958136681292339 0.09149698628777285 1.4178813447896027e-07 6.84836011150786 -0.5498168490609934 YWIDIQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YWIDIQLR 8 0 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 65505000.0 19729000.0 21703000.0 24073000.0 False True 29930335.383099504 17829930.08368705 19314960.998429295 1.0 0.5957143431728773 0.645330590225718 24.835105109196014 -10.353863372004778 5.535724477701942 1.0001005420605706 0.6205224667001392 0.9873408631381071 0.020255748038569377 2.5141462505114684e-05 2.934539283638193e-06 0.019617707590436927 0.006537514568193964 4.427276314999039e-11 10.353863372004778 -0.3795780753604314 YWIDIQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YWIDIQLR 8 0 Q6P2Q9 Q6P2Q9 PRPF8 Pre-mRNA-processing-splicing factor 8 0 49011000.0 19729000.0 12830000.0 16452000.0 False True 25539579.416730616 12115999.221523574 13457904.811775334 1.0 0.47440089062651336 0.5269430867353772 24.606231431288464 -10.694468894830806 10.456689659634389 1.0003188173746362 0.5006719891930388 0.9917640398873322 0.021450261738660683 0.00015952272676588277 4.661049399708931e-06 0.020781162332829086 0.006923042207135247 2.0208361637409374e-11 10.694468894830806 -0.49964682818159745 YWLCAATGPSIK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YWLCAATGPSIK 12 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;H0Y8R5;D6RF23;H0Y9P0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 499137000.0 189770000.0 232460000.0 76907000.0 False True 248790307.7352943 197777874.12198296 68949401.38403623 1.0 0.7949581152189131 0.27713861529282885 27.89035504177564 -6.955244277904722 0.4979541985516623 1.0105567595835707 0.039283507812083236 0.9995511555086821 0.006444256743511614 0.08144575720882678 0.02775747089202584 0.007586845509149223 0.04271277719845837 1.108551112393557e-07 6.955244277904722 -0.9712732517714875 down YWLCAATGPSIK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YWLCAATGPSIK 12 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;H0Y8R5;D6RF23;H0Y9P0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 172304000.0 125190000.0 22705000.0 24409000.0 False True 121215911.97554135 31771224.905010823 18015550.645696193 1.0 0.26210440846595734 0.14862364480111592 26.853003852475904 -13.999999999999998 0.2635648266652217 6.503643356540685 0.10854185244296527 0.9995696906313286 0.00782976127434719 14.57766939841528 0.1624741494110721 42.82316786390854 0.04869784105250918 1.0000000000000041e-14 13.999999999999998 -6.39510150409772 YWLCAATGPSIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YWLCAATGPSIK 12 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;H0Y8R5;D6RF23;H0Y9P0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 440620000.0 112580000.0 173890000.0 154150000.0 False True 170792090.7004586 142857970.89122885 123682184.93365498 1.0 0.8364437153110234 0.7241681065347066 27.347665925091064 -7.17304414259163 0.06181146627810482 1.5800205763584219 6.9001732617930955e-06 0.9999999290706276 2.960492783622588e-05 0.08772782041382539 0.0024547410521184956 0.02631537221066316 0.03598222830585433 6.7136061097335e-08 7.17304414259163 -1.58001367618516 YWLCAATGPSIK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YWLCAATGPSIK 12 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;H0Y8R5;D6RF23;H0Y9P0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 572170000.0 189770000.0 165530000.0 216870000.0 False True 259933097.3414204 158216337.26549023 165649772.57785162 1.0 0.6086809986250966 0.6372784930895958 27.95356510329853 -10.120186032687487 6.027003524104727 1.0000018781176294 0.6229797458573391 0.995703468549878 0.011674878226707245 2.946347792573191e-07 4.299901375069587e-08 0.011304208572446328 0.003768050745082644 7.582527032882564e-11 10.120186032687487 -0.37702213226029035 YWLCAATGPSIK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YWLCAATGPSIK 12 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;H0Y8R5;D6RF23;H0Y9P0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 229597300.0 125190000.0 9376300.0 95031000.0 False True 104101031.8573531 9325788.010850176 114901542.72630093 1.0 0.08958401126733362 1.103750276786377 26.63340912791018 -12.278936538964446 15.782061903204234 0.9718131687105758 0.637000434435226 0.0 0.46521996241526004 0.0 0.0 0.0 0.13605510780998803 5.260941359823956e-13 12.278936538964446 -0.33481273427534974 YWLCAATGPSIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YWLCAATGPSIK 12 0 P63244;J3KPE3;D6RAC2;H0Y8W2;H0YAF8;D6REE5;H0YAM7;H0Y8R5;D6RF23;H0Y9P0 P63244 GNB2L1 Guanine nucleotide-binding protein subunit beta-2-like 1;Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed 0 553590000.0 112580000.0 248700000.0 192310000.0 False True 145737029.28356922 234859626.3751299 157311553.26723298 1.0 1.611530216648986 1.079420611498417 27.118792247183514 -10.286085601325519 5.130854380829573 0.9999249369294073 1.345475414073777 0.359813441274631 0.2172328366423839 0.00018656770957164182 2.5959663882164107e-05 0.21038032230951612 0.0701115965470746 5.175048194534882e-11 10.286085601325519 0.3455504771443697 YWLMLNEK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YWLMLNEK 8 0 Q9H7Z7;X6RJ95;A6NHH0 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 0 5654300.0 2141000.0 1249300.0 2264000.0 False True 2932585.5583494804 1194101.7951173615 1729289.8285436244 1.0 0.40718395810058705 0.5896809467741171 21.48374176890136 -10.411310238189492 5.27898695901549 1.000391420757877 0.4984324524373463 0.9096764941395292 0.07450408364080985 0.0003434828739967493 3.830364395532291e-05 0.0721929129404949 0.024046089597102888 3.878731898546826e-11 10.411310238189492 -0.5019589683205308 YWLMLNEK(ub)EAQQVYGGK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YWLMLNEKEAQQVYGGK 17 1 Q9H7Z7;X6RJ95;A6NHH0 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 3241100.0 1205200.0 2035900.0 0.0 True False 1580028.8711734037 1732151.655876045 0.0 1.0 1.0962784841960944 0.0 20.59151948970006 -6.962168607338916 1.182832999832572 1.0574547205035567 3.0088682062540836e-20 0.9755295178649034 0.07753607502859249 0.10289536660559358 0.2851665575436807 0.054716070916210016 0.10297414971757306 1.0910166858136069e-07 6.962168607338916 -1.0574547205035567 down YWLMLNEK(ub)EAQQVYGGK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YWLMLNEKEAQQVYGGK 17 1 Q9H7Z7;X6RJ95;A6NHH0 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 22162100.0 7927600.0 5578300.0 8656200.0 True False 7675942.677348842 7805744.280450207 6388881.539566366 1.0 1.0169101840070276 0.8323253322903907 22.871912507093352 -6.884503206156705 1.0543210542067079 1.0112637440759662 0.8180572101345861 0.9771417376873947 0.012596332328694313 0.12371780364025034 0.24879213838860656 0.009162462068937139 0.0224345944419205 1.3046583370311848e-07 6.884503206156705 -0.1932065339413801 YWLMLNEK(ub)EAQQVYGGK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YWLMLNEKEAQQVYGGK 17 1 Q9H7Z7;X6RJ95;A6NHH0 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 53818000.0 10407000.0 18578000.0 24833000.0 True False 15788179.853612278 15262610.74942347 19924746.66530946 1.0 0.9667112289661078 1.2620040340337744 23.91234152334342 -6.878891879421386 1.086004033333761 0.9796574808190242 1.2824880326747992 0.9727786392163804 0.021787992009643875 0.12861418932852065 0.2782800515775906 0.015470168362558979 0.03730644201429108 1.321624620712564e-07 6.878891879421386 0.302830551855775 YWLMLNEK(ub)EAQQVYGGK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YWLMLNEKEAQQVYGGK 17 1 Q9H7Z7;X6RJ95;A6NHH0 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 19203200.0 7927600.0 5272700.0 6002900.0 True False 6592150.652227433 5244294.918550994 7258078.63572636 1.0 0.7955362665716673 1.1010183199126244 22.65231778252763 -6.726320561028117 1.7365216431470571 0.8764550380447574 1.1007224078244948 0.5421992521308777 0.08597926736437109 0.3431707829120859 2.0255532695178613 0.039263560573612924 0.0978429709931323 1.877930169088192e-07 6.726320561028117 0.22426736977973738 YWLMLNEK(ub)EAQQVYGGK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YWLMLNEKEAQQVYGGK 17 1 Q9H7Z7;X6RJ95;A6NHH0 Q9H7Z7 PTGES2 Prostaglandin E synthase 2;Prostaglandin E synthase 2 truncated form 1 56697000.0 10407000.0 19130000.0 27160000.0 True False 13472066.652639037 18065398.683378488 22217158.685133655 1.0 1.3409522940446308 1.6491277290987532 23.68346784543587 -6.972327009087667 0.19474323133079693 0.8036502107710982 2.194890722603261 0.9999952993820851 0.0005747706349908266 0.07555463820582022 0.00624788661052308 0.010452082743459629 0.03316522875632602 1.0657933126298412e-07 6.972327009087667 1.3912405118321627 YYADGEDAYAMK(ub)R ddPTM_RPMI8226_Bortezomib_1h_R1 2 YYADGEDAYAMKR 13 1 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;H0Y8T0;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 1 13716420.0 4055420.0 4541600.0 5119400.0 True False 5316694.892743142 3864010.9830181454 4589693.596752372 1.0 0.7267693672420825 0.863260670274108 22.34209824669917 -10.145289914110352 4.8846574178334965 1.0000137011172674 0.795015018757291 0.7504537384073695 0.05572234112878708 8.314759860749289e-06 1.4549149261661089e-06 0.05395652945025466 0.017984308266560833 7.1566550684288e-11 10.145289914110352 -0.20499868235997643 YYADGEDAYAMK(ub)R ddPTM_RPMI8226_Bortezomib_2h_R1 2 YYADGEDAYAMKR 13 1 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;H0Y8T0;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 1 22680200.0 5736600.0 5682400.0 11261200.0 True False 5554494.773056082 7951411.953324526 8311553.891241518 1.0 1.4315274886737646 1.4963654177080992 22.405224261936795 -11.945012261790055 0.30749430769269037 1.6113293361384135e-07 1.5125168528654624 0.9994828638570346 0.005009812836478018 5.075983569900475 0.16719905081119651 3.274890795258678 0.022681790877660462 1.1349787704393116e-12 11.945012261790055 1.5125166917325288 YYADGEDAYAMK(ub)R ddPTM_RPMI8226_Bortezomib_8h_R1 2 YYADGEDAYAMKR 13 1 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;H0Y8T0;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 1 101260600.0 13609600.0 24292000.0 63359000.0 True False 20646758.195034295 19956902.805737693 50836065.878763765 1.0 0.9665877140236709 2.462181491087072 24.299411942074286 -6.901790407405611 0.9498718216091502 0.9408363981505081 2.625009086880435 0.9874364179484846 0.07815716067335117 0.11009963018970959 0.17007699743109678 0.06149728963713717 0.16149317889695677 1.2537460928231627e-07 6.901790407405611 1.684172688729927 up YYADGEDAYAMK(ub)R ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYADGEDAYAMKR 13 1 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;H0Y8T0;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 1 11179200.0 3071400.0 3574800.0 4533000.0 True False 4206979.581464081 3416853.515717236 3462398.7600654787 1.0 0.8121868550947728 0.8230129699988991 22.004353385341027 -10.168446848290584 7.554777108910206 1.0000000952415216 0.8175999125476787 0.997364814286816 0.004419742901974876 7.089557882311534e-09 7.849906877262234e-10 0.004279399895335744 0.001426465887822267 6.785051551753869e-11 10.168446848290584 -0.18240018269384284 YYADGEDAYAMK(ub)R ddPTM_RPMI8226_Carfilzomib_2h_R1 2 YYADGEDAYAMKR 13 1 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;H0Y8T0;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 1 22294000.0 5736600.0 9648100.0 6909300.0 True False 4770237.0744699435 9596123.770302085 8354002.685006274 1.0 2.0116660074737234 1.751276205896863 22.18562953737107 -10.023221503631026 5.0715525878123024 0.9999901955282707 1.8814711066909713 0.9385727617630502 0.10630369136771395 1.178475233664602e-05 2.2697264080449314e-06 0.1029292493587252 0.03430936885613079 9.479348638585005e-11 10.023221503631026 0.8814809111627006 YYADGEDAYAMK(ub)R ddPTM_RPMI8226_Carfilzomib_8h_R1 2 YYADGEDAYAMKR 13 1 P41227;P41227-2;F8W808;A8MWP7;Q9BSU3;H0Y8T0;C9JW55 P41227;C9JW55 NAA10;NAA11 N-alpha-acetyltransferase 10;N-alpha-acetyltransferase 11 1 145186000.0 13609600.0 23420400.0 108156000.0 True False 17617895.485323 22117034.15181378 88472717.77427503 1.0 1.2553732181144388 5.021752901643633 24.070538264166736 -6.920633300725654 0.8200214300698108 0.9187792930737201 5.638041139200291 0.9943549302579575 0.13814368408517705 0.09780054649175335 0.1036955957372107 0.11942571783716706 0.3599285582321745 1.2005125356265194e-07 6.920633300725654 4.719261846126571 up YYAFPQMITPLVTK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YYAFPQMITPLVTK 14 0 Q14353;A0A1W2PR36 Q14353 GAMT Guanidinoacetate N-methyltransferase 0 5581300.0 1166300.0 1984000.0 2431000.0 False True 1529030.594465267 1687994.9335714278 2179463.4397986135 1.0 1.1039641323604477 1.4253890325594278 20.54418584328367 -6.9507717524297306 0.5503041193800225 0.995562785841848 1.5488983747167817 0.9992604741799579 0.004924065042174959 0.08317728698291237 0.0346909976566144 0.005342376968797339 0.026666458375917662 1.1200263692572357e-07 6.9507717524297306 0.5533355888749337 YYAFPQMITPLVTK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYAFPQMITPLVTK 14 0 Q14353;A0A1W2PR36 Q14353 GAMT Guanidinoacetate N-methyltransferase 0 6059700.0 1558600.0 1663100.0 2838000.0 False True 1509123.0961345045 2327184.5029519293 2094642.6618249766 1.0 1.5420773221964612 1.3879866176524849 20.525279057720095 -10.026946899970007 4.666757755797418 0.9999881978869873 1.4650319698797398 0.923917994150326 0.0629072667789924 43472169.83863715 1.141688529661284 6250.599811066194 0.021534830642711215 9.398382150561974e-11 10.026946899970007 0.4650437719927525 YYAFPQMITPLVTK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYAFPQMITPLVTK 14 0 Q14353;A0A1W2PR36 Q14353 GAMT Guanidinoacetate N-methyltransferase 0 7342500.0 1166300.0 2697800.0 3478400.0 False True 1597512.628072396 2578602.2755684126 2656873.559896706 1.0 1.6141357697308643 1.6631314915504394 20.607395904806562 -11.41804342731673 0.4242085472331527 1.6586580649673968e-11 1.6649742921623878 0.9997041120914634 0.00518997587080152 3.7805708085708396 0.21071901490033937 3.507683407988033 0.011747867455697666 3.819060801969648e-12 11.41804342731673 1.6649742921458013 YYAVNYPLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YYAVNYPLR 9 0 Q13547;Q5TEE2 Q13547 HDAC1 Histone deacetylase 1 0 18154500.0 2868400.0 13175000.0 2111100.0 False True 4351572.508129282 10823818.313255172 1693840.159672001 1.0 2.48733493306958 0.38924783087210324 22.053105404704997 -6.716291115568682 1.7727053858507686 1.9084421638963343 0.39318823353745325 0.4949475526354923 0.6261769960944077 0.3625697054500235 2.224630187254326 0.28069862715387783 0.7077392295740375 1.921803077151136e-07 6.716291115568682 -1.515253930358881 YYAVNYPLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYAVNYPLR 9 0 Q13547;Q5TEE2 Q13547 HDAC1 Histone deacetylase 1 0 7372800.0 2729700.0 2101800.0 2541300.0 False True 3738943.857368789 2008935.5262768487 1941097.279716392 1.0 0.5373002652386973 0.5191565730228436 21.834199377694972 YYDAIACLK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YYDAIACLK 9 0 O00170;E9PMH2;V9GYQ3 O00170 AIP AH receptor-interacting protein 0 9411100.0 2895000.0 2641000.0 3875100.0 False True 3795373.035219876 2246973.0945373685 3474141.824583965 1.0 0.5920295775108692 0.915362414272593 21.855810259869557 -9.868336107949531 6.356748439382385 1.0000000157677165 0.7536959958916938 0.4362121552126761 0.13200007785893866 2.9527556024462075e-08 5.093237117868433e-09 0.12780853533384973 0.04260284193712631 1.3541410137567463e-10 9.868336107949531 -0.24630401987602268 YYDAIACLK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYDAIACLK 9 0 O00170;E9PMH2;V9GYQ3 O00170 AIP AH receptor-interacting protein 0 7885700.0 2895000.0 1977800.0 3012900.0 False True 3965359.734433319 1890414.256290016 2301315.072623273 1.0 0.47673209567206415 0.5803546781997444 21.91902032139245 -9.967760006214439 5.97790552073239 1.0000003182794344 0.5285433869359101 0.965035298091471 0.04230374217070811 1.7941352089243513e-07 3.103913838936956e-08 0.04096044969251036 0.013653474075735132 1.0770602392796297e-10 9.967760006214439 -0.4714569313435243 YYDDTYPSVK(ub)EQK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YYDDTYPSVKEQK 13 1 F8VVA7;P61923;P61923-4;P61923-5;F8VXB1;F8VUC5;F8W156;F8VXR1;F8VYZ4 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 15412000.0 8283000.0 5452100.0 1676900.0 True False 10859093.212686108 4638667.932119347 1503390.4739606334 1.0 0.4271689948015397 0.13844530519401946 23.372400300302186 -8.90322794909453 0.2904244261800035 1.2451682477285007 2.2082518785791207e-23 0.9987410889130158 0.012703882175297889 0.3977739582609516 0.09651783583186208 0.2029347665372418 0.09849893530731509 1.249602976213491e-09 8.90322794909453 -1.2451682477285007 YYDDTYPSVK(ub)EQK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYDDTYPSVKEQK 13 1 F8VVA7;P61923;P61923-4;P61923-5;F8VXB1;F8VUC5;F8W156;F8VXR1;F8VYZ4 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 20993200.0 6684300.0 9902500.0 4406400.0 True False 6472110.555300838 13856619.890855307 3252231.6508335383 1.0 2.1409739176204816 0.5024993969192739 22.62580482113131 -6.719427544771353 1.7611730514785202 1.694565192942745 0.5050987797845379 0.5099171026515184 0.48015914644002866 0.356425381078732 2.160228269881852 0.21649357820924275 0.5438876033906126 1.90797401300352e-07 6.719427544771353 -1.1894664131582071 YYDDTYPSVK(ub)EQK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YYDDTYPSVKEQK 13 1 F8VVA7;P61923;P61923-4;P61923-5;F8VXB1;F8VUC5;F8W156;F8VXR1;F8VYZ4 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 38577500.0 9139500.0 12437000.0 17001000.0 True False 13865289.686950091 10217520.179275488 13640744.898196999 1.0 0.7369135741096087 0.9838052580347865 23.72497442307435 -10.524627247132834 8.26739808784584 1.0000164027198755 0.8603594161440876 0.298998047158362 0.10079310789219825 3.0476844150545042e-05 1.752383139472878e-06 0.09760396254248538 0.03253083568991426 2.987946058412464e-11 10.524627247132834 -0.13965698657578784 YYDDTYPSVK(ub)EQK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYDDTYPSVKEQK 13 1 F8VVA7;P61923;P61923-4;P61923-5;F8VXB1;F8VUC5;F8W156;F8VXR1;F8VYZ4 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 15818600.0 8283000.0 4981800.0 2553800.0 True False 11345448.939658456 4761687.603390432 1950645.0371619721 1.0 0.4197002365191358 0.17193193918871003 23.435610361825077 -9.802856710777318 0.22707290883568548 1.5340638071013173 5.616194467717066e-21 0.9992449768731478 0.009535426213584984 1.2476719173935222 0.0986467503215959 0.5581693562710188 0.12258416915153064 1.5745022631706365e-10 9.802856710777318 -1.5340638071013173 YYDDTYPSVK(ub)EQK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YYDDTYPSVKEQK 13 1 F8VVA7;P61923;P61923-4;P61923-5;F8VXB1;F8VUC5;F8W156;F8VXR1;F8VYZ4 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 24733000.0 6684300.0 14712000.0 3336700.0 True False 5558291.614698508 14632743.535896657 4034388.542842317 1.0 2.6325973069137656 0.7258324720087846 22.406210096565587 -6.680037747062915 1.9016995176570732 2.032957371115623 0.7331023383574778 0.3242224752683125 0.6919341757910459 0.43849923816475483 3.0660388031949806 0.2919484232467687 0.7699723388970195 2.0891145458498874e-07 6.680037747062915 -1.299855032758145 YYDDTYPSVK(ub)EQK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YYDDTYPSVKEQK 13 1 F8VVA7;P61923;P61923-4;P61923-5;F8VXB1;F8VUC5;F8W156;F8VXR1;F8VYZ4 F8VVA7 COPZ1 Coatomer subunit zeta-1 1 58096500.0 9139500.0 24032000.0 24925000.0 True False 11831262.916478777 22694598.074174166 20388905.752097026 1.0 1.9181889739399465 1.7233076380797034 23.4961007451668 -10.181425425013112 4.4571875139351365 0.9998174456465396 1.8207483060268173 0.9594308909910702 0.0795599722785119 55827090.59648541 36.68586914367861 105630.80906616196 0.02723549467161573 6.58528499623209e-11 10.181425425013112 0.8209308603802776 YYETHNVK(ub)NR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YYETHNVKNR 10 1 Q13823 Q13823 GNL2 Nucleolar GTP-binding protein 2 1 5987500.0 1418800.0 2997400.0 1571300.0 True False 1860060.5396787445 2550199.6037736866 1408716.9489739046 1.0 1.3710304311999102 0.7573500533575146 20.826918147040786 -6.742999613828555 1.6755366627904875 1.219987654616153 0.7567359224668821 0.6184191680484352 0.15588514197395847 0.3124092025290797 1.7231928406450896 0.07356463264505486 0.17994242547209943 1.8071757329375227e-07 6.742999613828555 -0.46325173214927085 YYETHNVK(ub)NR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYETHNVKNR 10 1 Q13823 Q13823 GNL2 Nucleolar GTP-binding protein 2 1 7992700.0 2948100.0 3203800.0 1840800.0 True False 2854514.17920835 4483094.047596288 1358639.2571837264 1.0 1.5705278608353581 0.4759616424678337 21.444813797964066 -6.7650469552831485 1.5932954526271217 1.3293055974013606 0.47090875461018306 0.7112932244919488 0.24017369443304257 0.2745196458831568 1.3744988154313302 0.11887073803705954 0.2842803395870272 1.717722659459963e-07 6.7650469552831485 -0.8583968427911775 down YYETHNVK(ub)NR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YYETHNVKNR 10 1 Q13823 Q13823 GNL2 Nucleolar GTP-binding protein 2 1 3661610.0 1209500.0 834810.0 1617300.0 True False 1834899.9262942323 685831.6330996995 1297639.9461122286 1.0 0.37377059275641616 0.7071993014534286 20.80726995131581 -10.621837793622456 6.701335124374313 1.001343099125592 0.5404849471050088 0.716906322404275 0.1361217003171287 0.002738288726933011 0.00015452397825694469 0.13212763052789722 0.04393308986547299 2.3887032826371462e-11 10.621837793622456 -0.4608581520205832 YYETHNVK(ub)NR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYETHNVKNR 10 1 Q13823 Q13823 GNL2 Nucleolar GTP-binding protein 2 1 4058460.0 1418800.0 1881100.0 758560.0 True False 1943368.701628324 1797986.7820341531 579403.7510335915 1.0 0.9251907682405519 0.2981440169063731 20.890128208563677 -6.929239666989692 0.753017665069509 1.0098097670493122 0.17187662972663867 0.9963864502005841 0.018918148061530776 0.09303490072376566 0.07963155852539354 0.01715791427684653 0.05697616887564787 1.1769562866630031e-07 6.929239666989692 -0.8379331373226736 down YYFEGIK(ub)QTFGYGAR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYFEGIKQTFGYGAR 15 1 O95433;G3V438;H0YJU2 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 1 12813400.0 4590300.0 4692900.0 3530200.0 True False 4444583.43910319 6566799.443150199 2605534.7162700924 1.0 1.477483668182686 0.5862269776165631 22.083616780617323 -6.761185180537341 1.6079606707392176 1.2769484328642675 0.5827781366749248 0.6957534398081182 0.2008674533570937 0.28095904661831567 1.4319772387348468 0.09854910636608243 0.23655726157143778 1.7330648718186467e-07 6.761185180537341 -0.6941702961893427 YYFEGIK(ub)QTFGYGAR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYFEGIKQTFGYGAR 15 1 O95433;G3V438;H0YJU2 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 1 6574200.0 1587600.0 2918500.0 2068100.0 True False 2174578.623276804 2789551.019811112 1579657.3738564788 1.0 1.2828007182410472 0.7264199863586183 21.052304440628323 -6.768514133197832 1.580006012267631 1.1625136723549248 0.7234546106090826 0.724895507955327 0.11914207948490214 0.2688381357685979 1.3242554728407052 0.059443354410189504 0.14170140925166574 1.7040638632492392e-07 6.768514133197832 -0.4390590617458422 YYFEGIK(ub)QTFGYGAR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YYFEGIKQTFGYGAR 15 1 O95433;G3V438;H0YJU2 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 1 14284000.0 4590300.0 5967600.0 3726100.0 True False 3817037.83476962 5935451.354324141 4505210.282460152 1.0 1.5549888712807005 1.1802896584943248 21.8640220560516 -10.424644864516395 5.516150209310981 0.9997535796682954 1.3676392648875144 0.5620877082778172 0.15297031305819947 0.0004638827611465843 4.8384917934999885e-05 0.14821068271175739 0.04937095624487758 3.761448633773073e-11 10.424644864516395 0.36788568521921905 YYFEGIK(ub)QTFGYGAR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YYFEGIKQTFGYGAR 15 1 O95433;G3V438;H0YJU2 O95433 AHSA1 Activator of 90 kDa heat shock protein ATPase homolog 1 1 17644800.0 3503000.0 3715800.0 10426000.0 True False 4534702.554453211 3509012.46354929 8528574.979793942 1.0 0.7738131490241487 1.8807352582406163 22.112576492230396 -6.853481562965284 1.2182509674182862 0.8788436929817685 1.928028126850027 0.9452087404108591 0.11177302261162528 0.1536705654225108 0.43714455990034534 0.07172556167946163 0.16638143902740668 1.4012590711062806e-07 6.853481562965284 1.0491844338682585 YYGGGSEGGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YYGGGSEGGR 10 0 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 7500820.0 446620.0 4277400.0 2776800.0 False True 585523.1450742321 3639228.593174615 2489483.372946442 1.0 6.215345411688613 4.251724964058982 19.15936667440984 -9.524909276025138 8.316982304039062 1.0000148531245887 5.2335351878736045 0.8610665759816684 0.8016446909109085 0.0 0.0 0.7761891459134469 0.25872971144916634 2.98600632951233e-10 9.524909276025138 4.233520334749016 YYGGGSEGGR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYGGGSEGGR 10 0 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 3223360.0 1516700.0 491160.0 1215500.0 False True 1468553.1886996077 687282.7493655634 897124.0857816266 1.0 0.4679999026621207 0.6108897469188862 20.485964088091144 -10.419065112337691 9.03911919783041 1.0000025831044694 0.5394448247905563 0.9326671003941007 0.058334534642472145 3.0366676551343858e-06 1.9521137097599515e-07 0.05648248701308468 0.018827390098254522 3.810086957356863e-11 10.419065112337691 -0.4605577583139131 YYGGGSEGGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYGGGSEGGR 10 0 P14866 P14866 HNRNPL Heterogeneous nuclear ribonucleoprotein L 0 6585120.0 446620.0 3520200.0 2618300.0 False True 611747.4834516788 3364665.9242552915 1999911.4655811724 1.0 5.500089522674862 3.2691780835730126 19.22257673593273 -8.972533921544 11.240467067655622 1.0000000001969007 4.384633803225732 0.7542396109271458 0.910765781205776 0.0 0.0 0.881845175719093 0.2939483919063643 1.0652856538940774e-09 8.972533921544 3.3846338030288314 YYGLQILENVIK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YYGLQILENVIK 12 0 O14980;C9JKM9;C9J673;C9IZS4;C9JQ02;C9JV99;H7BZC5 O14980 XPO1 Exportin-1 0 13571000.0 2678900.0 6125700.0 4766400.0 False True 4064087.153823578 5032520.974687447 3824318.9508126616 1.0 1.2382906134167784 0.9410031837566925 21.954499910174622 -6.693249517226613 1.8545836456679454 1.14893088931463 0.9419795154876137 0.3858459427259584 0.10071390357065976 0.4096995842912549 2.7344850995265575 0.043400585237639774 0.11256929685627493 2.0265180801417925e-07 6.693249517226613 -0.20695137382701623 YYGLQILENVIK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YYGLQILENVIK 12 0 O14980;C9JKM9;C9J673;C9IZS4;C9JQ02;C9JV99;H7BZC5 O14980 XPO1 Exportin-1 0 8704100.0 2678900.0 4046700.0 1978500.0 False True 3467888.859013621 3821497.5876648054 1618433.3011243318 1.0 1.10196656900699 0.46669122538853974 21.72562623226707 -6.865781294024655 1.156088927135698 1.0564373724742795 0.43233774272476755 0.9602932546309844 0.055508559152840524 0.14096902021676141 0.35478147214358824 0.03734855472786789 0.08783773473385537 1.3621304638551141e-07 6.865781294024655 -0.6240996297495119 down YYK(ub)VDENGK(ub)ISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YYKVDENGKISR 12 2 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 2 3640830.0 790930.0 1481900.0 1368000.0 True False 1036916.8893770151 1260806.296400957 1226452.4827826028 1.0 1.2159183723571674 1.1827876422376162 19.983868833688696 -10.05254467180065 4.4242851766598275 0.9999874644644497 1.1993530073114036 0.9797057303840299 0.01352556400164272 9370724.785264593 0.1396721518026227 1223.621674485827 0.004630160306492741 8.860440799266241e-11 10.05254467180065 0.19936554284695385 YYK(ub)VDENGK(ub)ISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYKVDENGKISR 12 2 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 2 6547600.0 1384300.0 2095600.0 3067700.0 True False 1340356.1542275092 2932384.0084096338 2264177.3409726825 1.0 2.187764796066208 1.689235606395676 20.35418496826572 -10.430736641546117 5.4775934021726 0.9992851069055388 1.938500201230946 0.8253356366330449 0.20352368942934826 0.0017780448726690732 0.00018478480103938986 0.19719487645167497 0.06568698830987701 3.7090557268684196e-11 10.430736641546117 0.9392150943254072 YYK(ub)VDENGK(ub)ISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYKVDENGKISR 12 2 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 2 3300230.0 790930.0 1486100.0 1023200.0 True False 1083358.1950795671 1420439.1881244767 781541.233465476 1.0 1.3111445453367827 0.7214061212765144 20.047078895211587 -6.763354413233941 1.5998427307804126 1.1799737634705743 0.7188863877490883 0.7045200334671642 0.1309387591528877 0.2773132844757081 1.3996164457283486 0.0645538913984974 0.15462379573084697 1.7244300677963882e-07 6.763354413233941 -0.46108737572148595 YYK(ub)VDENGK(ub)ISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YYKVDENGKISR 12 2 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 2 5341700.0 1384300.0 2855000.0 1102400.0 True False 1151106.7848880412 2839619.5483268704 1332906.7430783026 1.0 2.4668602301766964 1.157934920180271 20.134590243699996 -6.618832178700556 2.1212614255994398 1.9741061262353243 1.1629187059737798 0.07881119372977508 0.6309903644766293 0.5885420428761702 5.030786120544848 0.24456973432720197 0.6996448490270136 2.4052920802021284e-07 6.618832178700556 -0.8111874202615446 YYKVDENGK(ub)ISR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YYKVDENGKISR 12 2 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 96884000.0 47537000.0 26035000.0 23312000.0 True False 62321467.348962896 22150679.48363516 20899897.864494186 1.0 0.35542615451598114 0.3353563186737449 25.893225866034584 YYKVDENGK(ub)ISR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYKVDENGKISR 12 2 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 50445000.0 27345000.0 11178000.0 11922000.0 True False 26476947.94289622 15641433.692499919 8799270.54766645 1.0 0.5907566735499257 0.332337041514156 24.658233493251643 -8.530550670421906 0.18731323428403038 1.3441551814522787 3.1776255317538045e-09 0.9997652707541917 0.004211409324732102 0.169941563923679 0.04805245740827516 0.1603678354847365 0.13202769815411897 2.9474695665510596e-09 8.530550670421906 -1.3441551782746533 down YYKVDENGK(ub)ISR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YYKVDENGKISR 12 2 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 1041140000.0 379480000.0 221420000.0 440240000.0 True False 575698903.7041215 181905871.03764388 353226371.0359532 1.0 0.31597397505403935 0.6135609582774066 29.100739224050702 -10.46881847985284 6.174135534622091 1.0002811614695966 0.46476746666605434 0.8117881982726977 0.12148937716523811 0.00047042810118261746 4.0472269354355885e-05 0.11769148357307022 0.03921052787517319 3.397672539357137e-11 10.46881847985284 -0.5355136948035422 YYKVDENGK(ub)ISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYKVDENGKISR 12 2 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 133911900.0 47537000.0 78196000.0 8178900.0 True False 65112713.53912159 74741042.16040753 6247212.269732973 1.0 1.1478717150299835 0.0959445848617485 25.956435927557475 -6.871314411198228 1.1271971867423434 1.0843238209823776 0.03280083449896734 0.9659735823571374 0.08576862987477678 0.13559678592425659 0.32121010446659026 0.05900639904238485 0.14001963554232894 1.3448863595698773e-07 6.871314411198228 -1.0515229864834101 down YYKVDENGK(ub)ISR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YYKVDENGKISR 12 2 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 90960100.0 27345000.0 58253000.0 5362100.0 True False 22738579.088899437 57939179.52668487 6483290.318450806 1.0 2.548056292355125 0.28512293108129305 24.43863876868592 -6.722561919938796 1.750098752074963 1.939234373336618 0.28813322719168943 0.524572018619077 0.6512316180821178 0.3503669227323259 2.098567370825384 0.2953060374304833 0.7391036266453368 1.894253420163279e-07 6.722561919938796 -1.6511011461449285 YYKVDENGK(ub)ISR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YYKVDENGKISR 12 2 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 1 965050000.0 379480000.0 446970000.0 138600000.0 True False 491244340.66911376 422095726.58179295 113376222.15609436 1.0 0.8592378408000896 0.23079395072860676 28.87186554614315 -6.94236022983943 0.6372326711595171 1.0068684146041522 0.048871582519700967 0.9984569324728789 0.013136018300757628 0.08670632596733414 0.049829762356701196 0.01302833024364919 0.05355181183604282 1.1419307561316742e-07 6.94236022983943 -0.9579968320844513 down YYKVDENGKISR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYKVDENGKISR 12 2 P62979 P62979 RPS27A Ubiquitin-40S ribosomal protein S27a;Ubiquitin;40S ribosomal protein S27a 0 1546130.0 409500.0 801570.0 335060.0 False True 560903.216321398 766153.9869624773 255925.7287773084 1.0 1.365929031370486 0.45627431137899327 19.09739233015686 -6.797566291098379 1.4662836247070068 1.2025272705984458 0.4445221829589624 0.8248173681097808 0.1564206983128359 0.22425520630251333 0.9521792697770103 0.08394180837230618 0.19547491644671527 1.5937995831494071e-07 6.797566291098379 -0.7580050876394834 down YYLAPK(ub)IEDEEGS ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYLAPKIEDEEGS 13 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 27513700.0 6418800.0 8662900.0 12432000.0 True False 6215038.7074734885 12122041.146426696 9175686.2479944 1.0 1.9504369509155475 1.476368318826523 22.567331945783938 -10.232321889418841 4.922406098058925 0.999881283442079 1.7134026348719005 0.7512088267078773 0.19353770861587802 0.00025218967499953114 3.9330868363369964e-05 0.1874229179548946 0.06246402686060962 5.857038928881146e-11 10.232321889418841 0.7135213514298214 YYLAPK(ub)IEDEEGS ddPTM_RPMI8226_Bortezomib_8h_R1 1 YYLAPKIEDEEGS 13 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 95117000.0 18093000.0 15383000.0 61641000.0 True False 27448403.775478736 12637783.462072432 49457629.331789926 1.0 0.4604196136666608 1.8018399079356782 24.710218917917068 -6.797541397206606 1.4660815158421434 0.7013562435401345 1.8192213991564972 0.8248363484507119 0.2306537335477086 0.22428535380990935 0.9519994549950624 0.1237877329973966 0.2883071941346224 1.59389094284455e-07 6.797541397206606 1.1178651556163626 YYLAPK(ub)IEDEEGS ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYLAPKIEDEEGS 13 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 22601100.0 5735100.0 7726500.0 9139500.0 True False 7855521.455249929 7385117.681881279 6980938.333910984 1.0 0.9401180715948176 0.8886664461014931 22.905275615172535 -6.972893284147159 0.1758549879428329 1.0420282009970094 0.78537067171006 0.9999970279608864 7.821903989433987e-05 0.07537466732823848 0.005520335384887953 0.002055942078741789 0.005848688407394801 1.0644045340570935e-07 6.972893284147159 -0.2566575292869494 YYLAPK(ub)IEDEEGS ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YYLAPKIEDEEGS 13 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 23479000.0 6418800.0 8610000.0 8450200.0 True False 5337516.601054231 8563616.221048804 10217097.750689652 1.0 1.6044195945652657 1.9142043977290186 22.347737221218214 -10.085002403067941 0.1497439765233465 6.936160220875251e-16 2.373696869445289 0.9997234791821933 0.0063128054396862305 1.6926637234357516 0.07139026300241948 0.9333304908955594 0.2752583048529346 8.222381002703711e-11 10.085002403067941 2.373696869445288 YYLAPK(ub)IEDEEGS ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YYLAPKIEDEEGS 13 1 P12004 P12004 PCNA Proliferating cell nuclear antigen 1 85150000.0 18093000.0 16520000.0 50537000.0 True False 23421745.16634941 15600647.477752898 41339784.55340937 1.0 0.6660753657317869 1.7650172632226926 24.481345240009517 -6.825206324030187 1.3494040679235006 0.8209056162307045 1.7917525496065796 0.8958963707047725 0.1484206158291918 0.1868060758563211 0.6669445950797627 0.08640360555507738 0.19890414926280164 1.4955249953226904e-07 6.825206324030187 0.9708469333758751 YYLCGFCPAELFTNTR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYLCGFCPAELFTNTR 16 0 J3KPP4;O95232;D6RDI2;H7C5U7;C9JL41;O95232-2 J3KPP4 LUC7L3 Luc7-like protein 3 0 9288600.0 1000500.0 1364200.0 6923900.0 False True 1370411.8874958684 1303925.1331938705 5288617.4221966425 1.0 0.9514841086036636 3.85914444441988 20.386178140421592 -6.903106295788678 0.9414151707075481 0.8891962898691951 4.184367206914485 0.9880495284845988 0.14860643651291194 0.10915496699081792 0.16480250322425538 0.11766301450326454 0.3111993812427607 1.2499530603910456e-07 6.903106295788678 3.2951709170452896 up YYLCLQLR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YYLCLQLR 8 0 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A8K968;A0A0A0MRA8;Q9Y2J2-2;Q9Y2J2;Q9Y2J2-4;A0A1B0GTF8;Q9Y2J2-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0-4;Q9H4G0-3;Q9H4G0;Q4VXN0;Q4VXN1 P11171;A8K968;Q9H4G0-2 EPB41;EPB41L3;EPB41L1 Protein 4.1;Band 4.1-like protein 3;Band 4.1-like protein 3, N-terminally processed;Band 4.1-like protein 1 0 307840000.0 100370000.0 100460000.0 107010000.0 False True 152268628.02988985 82532128.10243738 85859426.59585083 1.0 0.5420166266043757 0.5638681303347456 27.182043492467976 -10.1136960923888 5.152725372574316 1.0000121007937544 0.5529423784692514 0.9982113737079263 0.008920839044338987 1.242050652480107e-06 2.136316930575542e-07 0.008637799205240717 0.0028791884207388942 7.696688454649537e-11 10.1136960923888 -0.4470697223245029 YYLCLQLR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYLCLQLR 8 0 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A8K968;A0A0A0MRA8;Q9Y2J2-2;Q9Y2J2;Q9Y2J2-4;A0A1B0GTF8;Q9Y2J2-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0-4;Q9H4G0-3;Q9H4G0;Q4VXN0;Q4VXN1 P11171;A8K968;Q9H4G0-2 EPB41;EPB41L3;EPB41L1 Protein 4.1;Band 4.1-like protein 3;Band 4.1-like protein 3, N-terminally processed;Band 4.1-like protein 1 0 6523530.0 789430.0 1641300.0 4092800.0 False True 1081303.604543593 1568781.9389467086 3126164.933861904 1.0 1.4508246641875158 2.8911074750198633 20.04434022400859 -6.950028405009219 0.5585303363303538 0.9810161618530622 3.4295761401947553 0.9992035201471858 0.02276095316429671 0.08347431177218778 0.03591497723796228 0.024441975762863263 0.11968868994488155 1.1219450711400078e-07 6.950028405009219 2.4485599783416934 up YYLCLQLR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YYLCLQLR 8 0 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A8K968;A0A0A0MRA8;Q9Y2J2-2;Q9Y2J2;Q9Y2J2-4;A0A1B0GTF8;Q9Y2J2-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0-4;Q9H4G0-3;Q9H4G0;Q4VXN0;Q4VXN1 P11171;A8K968;Q9H4G0-2 EPB41;EPB41L3;EPB41L1 Protein 4.1;Band 4.1-like protein 3;Band 4.1-like protein 3, N-terminally processed;Band 4.1-like protein 1 0 11676500.0 5614900.0 1121600.0 4940000.0 False True 4669038.132245802 1115557.7181798315 5972931.160020698 1.0 0.2389266668171865 1.2792637350228118 22.154693940508103 -6.710569580238641 1.7931952306519294 0.5324054320608355 1.276867720012266 0.4679471066639167 0.32067944343603066 0.37385411280966047 2.343735838409036 0.14229560350865475 0.36124544405082404 1.9472890411641244e-07 6.710569580238641 0.7444622879514305 YYLCLQLR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YYLCLQLR 8 0 P11171;P11171-2;A0A2R8YD30;A0A2R8Y7Y3;A0A2U3TZH6;Q4VB86;P11171-3;P11171-5;P11171-4;A0A3B3ITP0;P11171-6;P11171-7;A0A2R8Y5Z6;A0A2R8Y5G2;A0A2R8Y570;A0A2R8Y6G5;A0A2R8YFR9;A0A3B3IU06;A0A2R8Y420;A0A2R8Y7N0;A0A2R8Y6D0;A0A3B3ITC5;A0A2R8Y6T6;A0A3B3IUD6;A0A2R8YCW8;A0A1B0GWG0;A8K968;A0A0A0MRA8;Q9Y2J2-2;Q9Y2J2;Q9Y2J2-4;A0A1B0GTF8;Q9Y2J2-3;Q9H4G0-2;A0A0C4DH22;A0A1B0GTW6;Q9H4G0-4;Q9H4G0-3;Q9H4G0;Q4VXN0;Q4VXN1 P11171;A8K968;Q9H4G0-2 EPB41;EPB41L3;EPB41L1 Protein 4.1;Band 4.1-like protein 3;Band 4.1-like protein 3, N-terminally processed;Band 4.1-like protein 1 0 257352000.0 100370000.0 78005000.0 78977000.0 False True 129930943.58848657 73663953.17809416 64603996.3724521 1.0 0.5669469576962394 0.49721794199435637 26.953169814560425 -13.999999999999998 0.2570219490376965 4.121544516330423 0.470996008045798 0.999556317886872 0.004684740616143311 14.287440198962456 0.1604233820578781 23.122845288514537 0.030970260574884532 1.0000000000000041e-14 13.999999999999998 -3.6505485082846247 YYNK(ub)YINVK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYNKYINVK 9 1 C9JU26;P56134-2;P56134 C9JU26 ATP5J2 ATP synthase subunit f, mitochondrial 1 3428280.0 323380.0 1306800.0 1798100.0 True False 313114.4789092629 1828612.054871971 1327123.6681562671 1.0 5.840075046168281 4.238461513435324 18.256330696958816 -9.726800196921426 7.723643399547733 1.0000006658255904 5.039268279682741 0.894521899105062 0.6538559867222073 7.759036741767116e-09 0.0 0.633093308546739 0.21103111228273216 1.8758573232322195e-10 9.726800196921426 4.039267613857151 YYNK(ub)YINVK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YYNKYINVK 9 1 C9JU26;P56134-2;P56134 C9JU26 ATP5J2 ATP synthase subunit f, mitochondrial 1 3999050.0 323380.0 1364700.0 2310970.0 True False 268904.7981630394 1357348.0902282584 2794183.1422819896 1.0 5.047690110033984 10.390975398616172 18.036735972393092 -6.9672935106397365 0.3162263323232178 0.23506561026655096 15.374992812822324 0.9999529161440688 0.02639030518520985 0.07719106264865683 0.012159356636760514 0.08226939579596224 0.4716067414169029 1.0782177805376041e-07 6.9672935106397365 15.139927202555773 YYNSDVHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYNSDVHR 8 0 P19623;K7EL89 P19623 SRM Spermidine synthase 0 2221480.0 889200.0 491920.0 840360.0 False True 860972.832723472 688346.2213289104 620244.5057403934 1.0 0.799498189915586 0.7203996248968799 19.71560818974362 -13.99999999999998 0.1284749240779365 1.9527301064675366 0.6074517511229539 0.9996525722217281 0.002193449566640928 11.939333502263501 0.11131089403442343 2.876484312328376 0.10039462017664802 1.000000000000045e-14 13.99999999999998 -1.3452783553445826 YYPTEDVPR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YYPTEDVPR 9 0 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 0 20373340.0 639740.0 11653000.0 8080600.0 False True 838705.3352509725 9914417.823038239 7244497.026588516 1.0 11.821097835357715 8.637714250882507 19.67780450793719 -10.149166713971736 7.993209213988479 0.99999854022713 10.229406043120111 0.9180830677002213 1.2996109062527283 3.3816980147699165e-05 3.603207188146059e-06 1.2583429982036418 0.4194476163721958 7.093054324160621e-11 10.149166713971736 9.22940750289298 YYPTEDVPR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYPTEDVPR 9 0 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 0 12133800.0 4611900.0 1854900.0 5667000.0 False True 4465497.758926424 2595571.243175713 4182642.6936441613 1.0 0.5812501502183552 0.9366576626946364 22.09038956758443 -10.087271357539958 7.2956373012215705 1.0000000528643584 0.7589539064564959 0.3801594053956405 0.14509450938645588 1.247262004425096e-07 1.578179427238196e-08 0.14048718602118893 0.04682905153998994 8.179535515671378e-11 10.087271357539958 -0.2410461464078626 YYPTEDVPR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYPTEDVPR 9 0 Q02878;F8VZ45;U3KQR5;F8VR69 Q02878 RPL6 60S ribosomal protein L6 0 18903240.0 639740.0 7329500.0 10934000.0 False True 876269.1663234452 7005658.454584726 8351614.3927985905 1.0 7.99487043915776 9.530877855533118 19.74101456946008 -9.261734860211732 0.5203071372741082 1.3652988436343569e-18 9.502833268303268 0.9977545762290092 0.17593399193068024 0.6424572541800706 0.2171761794270475 1.766566249182319 0.2988601555911489 5.473500218891601e-10 9.261734860211732 9.502833268303268 YYQQLK(ub)LEGPGEQETK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YYQQLKLEGPGEQETK 16 1 Q99808;Q99808-2 Q99808 SLC29A1 Equilibrative nucleoside transporter 1 1 41101500.0 6302400.0 7939100.0 26860000.0 True False 8262507.432528418 6754617.226369419 24080784.85931334 1.0 0.8175021059318348 2.914464532220621 22.97814823371964 -6.885709482353562 1.047462479425567 0.8754677190949491 3.0803414088188235 0.9780057484433407 0.14065701049632953 0.12269199216500656 0.24275287651029126 0.10285244073481745 0.2527484912987072 1.3010396065202952e-07 6.885709482353562 2.2048736897238745 up YYQQLK(ub)LEGPGEQETK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYQQLKLEGPGEQETK 16 1 Q99808;Q99808-2 Q99808 SLC29A1 Equilibrative nucleoside transporter 1 1 76404600.0 3983000.0 8302600.0 64119000.0 True False 3856561.8451839704 11617871.47748703 47324310.37123175 1.0 3.0124945336985305 12.271114083216323 21.878883815968177 -6.94167911270726 0.643761599229953 0.8983356337194439 14.896157513386797 0.9983755542453251 0.1978204519431102 0.08700915399486835 0.051185230624683324 0.1951061555407912 0.7911639213774131 1.143723085686439e-07 6.94167911270726 13.997821879667352 YYQQLK(ub)LEGPGEQETK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YYQQLKLEGPGEQETK 16 1 Q99808;Q99808-2 Q99808 SLC29A1 Equilibrative nucleoside transporter 1 1 198966100.0 6451100.0 92515000.0 100000000.0 True False 9786790.338583477 76004975.4270057 80234956.1684429 1.0 7.7660778250621565 8.198291103889733 23.22240436257073 -9.784881677969452 0.6997873456809443 5.949624671531825e-21 8.126463141681421 0.9995861660325434 0.06705347599202645 1.0668747698245546 0.343777204771414 2.700098035117262 0.06707573937807788 1.6410368071065554e-10 9.784881677969452 8.126463141681421 YYQQLK(ub)LEGPGEQETK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYQQLKLEGPGEQETK 16 1 Q99808;Q99808-2 Q99808 SLC29A1 Equilibrative nucleoside transporter 1 1 45343400.0 6302400.0 3726000.0 35315000.0 True False 8632567.595955983 3561372.9997657 26974324.335255366 1.0 0.4125508384590076 3.1247162603038023 23.04135829524253 -6.849989104826488 1.235053413374862 0.6865043176503934 3.2331684231794187 0.9403004945445533 0.28465393616429996 0.15746996801453894 0.46221316942096996 0.18034465255672216 0.4173481128005423 1.4125729814872022e-07 6.849989104826488 2.5466641055290253 up YYQQLK(ub)LEGPGEQETK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YYQQLKLEGPGEQETK 16 1 Q99808;Q99808-2 Q99808 SLC29A1 Equilibrative nucleoside transporter 1 1 56227900.0 3983000.0 9919900.0 42325000.0 True False 3312040.9768179366 9866459.52975402 51174961.811310925 1.0 2.978966624752717 15.451186192894744 21.659289091402453 -6.934803352182137 0.7062522044459686 0.8398585507401982 18.355850249756706 0.9974009393099366 0.3261319363027603 0.09021924723045768 0.06601657467395274 0.3061240367284102 1.1002448548901929 1.1619746349194403e-07 6.934803352182137 17.515991699016507 YYQQLK(ub)LEGPGEQETK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YYQQLKLEGPGEQETK 16 1 Q99808;Q99808-2 Q99808 SLC29A1 Equilibrative nucleoside transporter 1 1 144541100.0 6451100.0 58719000.0 79371000.0 True False 8351076.120192155 55451236.03185068 64926292.4152334 1.0 6.64001084815579 7.774601917260392 22.99353068466318 -9.393033418565897 0.5072367189392518 9.947372494800789e-18 7.761857003024751 0.9981337847924079 0.12798287154348473 0.7387425226598058 0.21496524254484942 1.7428167197986189 0.22577901085890317 4.0454476114781623e-10 9.393033418565897 7.761857003024751 YYQTIGNHASYYK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YYQTIGNHASYYK 13 0 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 0 11867900.0 5248800.0 3399800.0 3219300.0 False True 6881227.629451511 2892563.092316601 2886197.7177061625 1.0 0.42035567606229024 0.419430641322385 22.714234537874848 YYQTIGNHASYYK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYQTIGNHASYYK 13 0 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 0 11464900.0 2598100.0 1073900.0 7792900.0 False True 2515624.7376280418 1502713.870314518 5751705.70801123 1.0 0.597352159818325 2.286392569598619 21.262485296970123 -6.843802283214474 1.2646598488477758 0.7857990191017394 2.346251132524125 0.9307996522760672 0.18948790546738067 0.16439483916990666 0.5090937488792366 0.1174115896183337 0.2708275705748233 1.4328400651810022e-07 6.843802283214474 1.5604521134223857 up YYQTIGNHASYYK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YYQTIGNHASYYK 13 0 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 0 20810700.0 738000.0 18686900.0 1385800.0 False True 1119599.955026988 15352076.693583915 1111896.022582284 1.0 13.712109065968884 0.993119031123471 20.09455190339628 -6.6463080500644836 2.0219097286322034 9.272910087368356 1.046633317888947 0.17919020449485135 5.430629703584776 0.5175977165011479 4.051609100817167 2.1815873504620096 6.013593116888858 2.257833694728876e-07 6.6463080500644836 -8.226276769479409 YYQTIGNHASYYK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYQTIGNHASYYK 13 0 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 0 15700090.0 5248800.0 3592100.0 6859190.0 False True 7189423.203486579 3433389.1445137872 5239190.591452366 1.0 0.47756114048881315 0.7287358725678537 22.77744459939774 -10.085502949671488 5.127706780630343 1.0000081162462409 0.6031485065273938 0.7689707604896283 0.10254165498226588 9.514584562337469e-06 1.6967384939570424e-06 0.09928756090679687 0.033095176836100956 8.212909747144095e-11 10.085502949671488 -0.39685960971884704 YYQTIGNHASYYK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YYQTIGNHASYYK 13 0 Q9UNM6;J3KNQ3;A0A087WUL9;Q9UNM6-2;E9PL38;H0YD73 Q9UNM6 PSMD13 26S proteasome non-ATPase regulatory subunit 13 0 6685100.0 2598100.0 2244700.0 1842300.0 False True 2160435.265345392 2232607.355561934 2227516.412167235 1.0 1.033406272973888 1.0310498295865942 21.0428905724044 -10.077386536111929 4.798504807254512 0.9999987947997114 1.0322280512781796 0.9960062131456519 0.0009620139858527835 1.240381915709173e-08 2.3836412884977987e-09 0.000931500875720543 0.0003104886786344213 8.3678418565176e-11 10.077386536111929 0.03222925647846819 YYRPTEVDFLQGDCTK(ub)AK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYRPTEVDFLQGDCTKAK 18 2 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 1 20157500.0 2565900.0 4402600.0 13189000.0 True False 2484446.909002649 6160581.139255692 9734405.238481177 1.0 2.479659000533355 3.918137756620018 21.244493282096894 -6.971470790208768 0.22024226890740553 0.33866330425806984 6.099763562245576 0.9999916937188771 0.003433580844652966 0.0758282920481378 0.007298255754307987 0.03977096488962008 0.14572238103028534 1.067896614746164e-07 6.971470790208768 5.761100257987506 YYRPTEVDFLQGDCTK(ub)AK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YYRPTEVDFLQGDCTKAK 18 2 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 1 190835000.0 10115000.0 33079000.0 147641000.0 True False 15345194.505552808 27175794.00259334 118459691.63665083 1.0 1.7709644535792306 7.719660483533463 23.871283596781527 -6.930774969892334 0.740400901693783 0.9120899146094059 8.965362420582734 0.9966884117696512 0.17278322914144195 0.09223741956396314 0.07572282234868122 0.15814571351137144 0.5359789830480475 1.172802897098383e-07 6.930774969892334 8.053272505973329 YYRPTEVDFLQGDCTK(ub)AK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YYRPTEVDFLQGDCTKAK 18 2 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 1 30288600.0 2565900.0 2233500.0 25489200.0 True False 2133659.5386435213 2221467.692184962 30818873.871254988 1.0 1.0411537792000616 14.444138492145825 21.02489855753117 -6.9075720724768885 0.9121051674198724 0.5524835364560401 16.089249833062233 0.989972748557597 0.6336566349841747 0.10604564345089786 0.14763644021761085 0.5126342536939799 1.3924007718042977 1.237165861498691e-07 6.9075720724768885 15.536766296606192 up YYRPTEVDFLQGDCTK(ub)AK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YYRPTEVDFLQGDCTKAK 18 2 O60547;O60547-2 O60547 GMDS GDP-mannose 4,6 dehydratase 1 179806300.0 10115000.0 24161300.0 145530000.0 True False 13094066.896458516 22816702.415510334 119045033.26389909 1.0 1.7425222122304453 9.091524749739637 23.642409918873977 -6.926365233066701 0.7760521514307488 0.871907797114029 10.469455344407148 0.995774314355036 0.23739729687059932 0.09456946760177058 0.08725294527714107 0.2117749281455988 0.6787315908333118 1.1847719593091618e-07 6.926365233066701 9.59754754729312 up YYSADINLCVVPNK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YYSADINLCVVPNK 14 0 Q6PD74 Q6PD74 AAGAB Alpha- and gamma-adaptin-binding protein p34 0 9925000.0 0.0 9925000.0 0.0 False True 0.0 8153806.20562106 0.0 0.0 YYSNLTK(ub)SER ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YYSNLTKSER 10 1 O00418;H3BRH4 O00418 EEF2K Eukaryotic elongation factor 2 kinase 1 643160.0 643160.0 0.0 0.0 True False 832583.2985789686 0.0 0.0 1.0 0.0 0.0 19.667235093089136 -10.023149904605134 3.6440175408780493 1.0002756387197687 1.0976821393805986e-42 0.9999999998499973 2.450214222014978e-08 3.459116861175329 6.231285946097866 0.01186327560296681 6.879084046024038e-09 9.480911559845074e-11 10.023149904605134 -1.0002756387197687 YYSSEYHYVGGFYGGCNEALMK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YYSSEYHYVGGFYGGCNEALMK 22 0 P53634 P53634 CTSC Dipeptidyl peptidase 1;Dipeptidyl peptidase 1 exclusion domain chain;Dipeptidyl peptidase 1 heavy chain;Dipeptidyl peptidase 1 light chain 0 26464700.0 4924600.0 15341000.0 6199100.0 False True 6374991.778378621 14487259.8641772 5070927.408137402 1.0 2.272514282028111 0.7954406192861181 22.603992050699585 -6.678800614800848 1.9064949994302978 1.8060375768225128 0.8011721180863323 0.31841335551457617 0.5394707525483095 0.4412407206157935 3.0998157233978163 0.2271581193144804 0.5999604142517477 2.095074086510694e-07 6.678800614800848 -1.0048654587361805 YYSSHYMTLVVQSK ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYSSHYMTLVVQSK 14 0 O43847-2;G3V1R5;O43847;F5H7V1 O43847-2 NRD1 Nardilysin 0 8922800.0 2774100.0 1566500.0 4582200.0 False True 2686037.7139655696 2192011.619189584 3381984.3569465857 1.0 0.8160762627392066 1.2590978672274655 21.357048130742218 -6.793936239917582 1.48040239708573 0.8977287415328109 1.264345458551474 0.8138781334344152 0.07840109866616746 0.22953036747159491 0.993600291640733 0.041674849892885384 0.09730589599896428 1.60717719022255e-07 6.793936239917582 0.36661671701866305 YYSSHYMTLVVQSK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YYSSHYMTLVVQSK 14 0 O43847-2;G3V1R5;O43847;F5H7V1 O43847-2 NRD1 Nardilysin 0 30353000.0 5533000.0 14650000.0 10170000.0 False True 8393965.516482828 12035593.039027568 8159895.042330656 1.0 1.4338387518263984 0.9721144346265732 23.00092110577871 -6.660230486780156 1.9722736974948507 1.2792062418571906 0.9740463934083008 0.23652511935632692 0.18470896848394533 0.4838815232433217 3.618631234651488 0.07566115863231833 0.20473835989160738 2.1866008531581522e-07 6.660230486780156 -0.30515984844888977 YYSSHYMTLVVQSK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYSSHYMTLVVQSK 14 0 O43847-2;G3V1R5;O43847;F5H7V1 O43847-2 NRD1 Nardilysin 0 9928900.0 3061100.0 2398800.0 4469000.0 False True 4192871.3931170446 2292813.0842291866 3413514.241944104 1.0 0.5468360150499809 0.8141232873366158 21.9995071487673 -10.263511710610482 5.714288157598637 1.0000197693418544 0.6804796511932945 0.6558097060154298 0.10911957197378293 2.7484343742126387e-05 3.542467219979144e-06 0.10566110108795489 0.035218190416643036 5.4511519663546056e-11 10.263511710610482 -0.31954011814856 YYSSHYMTLVVQSK ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YYSSHYMTLVVQSK 14 0 O43847-2;G3V1R5;O43847;F5H7V1 O43847-2 NRD1 Nardilysin 0 7437500.0 2774100.0 2004300.0 2659100.0 False True 2306787.0634673983 1993502.4380776014 3215105.5157107404 1.0 0.86419005449125 1.3937591235135602 21.137453406176494 -6.838666299324163 1.2885920154209225 0.9277355281154158 1.4107204881234658 0.9221352087258353 0.06266797420038273 0.17036112684553878 0.5500749505780723 0.03814302399290554 0.0878444182121939 1.4498854802474057e-07 6.838666299324163 0.48298496000805 YYSSHYMTLVVQSK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YYSSHYMTLVVQSK 14 0 O43847-2;G3V1R5;O43847;F5H7V1 O43847-2 NRD1 Nardilysin 0 26194700.0 5533000.0 14184000.0 6477700.0 False True 7162577.571735548 13394647.931261921 5298825.066814799 1.0 1.8700876600790928 0.7397930442979974 22.772047427871158 -6.70106061009476 1.8268180346556226 1.5397118020675549 0.7430549034306811 0.4227653359842347 0.3672019589964358 0.39330425461441865 2.5524740735153335 0.16030470853330547 0.41176371153228886 1.990395540198951e-07 6.70106061009476 -0.7966568986368737 YYTGNYDQYVK(ub)TR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YYTGNYDQYVKTR 13 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 12888000.0 2402100.0 5486900.0 4999000.0 True False 3149176.361969488 4668275.907768689 4481751.4337940235 1.0 1.4823799531027724 1.4231503474740759 21.586543123689875 -10.531798107950557 6.133822553606641 0.9993918570861586 1.4527651502884236 0.9873277327561552 0.024180385242764238 0.00020135048599848878 1.5369311082409403e-05 0.02344226731176249 0.007804185779175451 2.939015605272872e-11 10.531798107950557 0.45337329320226494 YYTGNYDQYVK(ub)TR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYTGNYDQYVKTR 13 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 15853200.0 4504300.0 4572500.0 6776400.0 True False 4361313.4620291665 6398323.095272495 5001457.552357561 1.0 1.4670633402020088 1.1467778218423579 22.056331254736346 -10.180255651956404 4.787561815211489 0.9999634868835038 1.3069205810235114 0.5504364845619083 0.13075601533522943 5.09659270874703e-05 8.726375434335793e-06 0.12661900663658834 0.04220132248349967 6.603046383985447e-11 10.180255651956404 0.3069570941400076 YYTGNYDQYVK(ub)TR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YYTGNYDQYVKTR 13 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 38906800.0 8210800.0 10951000.0 19745000.0 True False 12456383.889885642 8996708.489446469 15842392.095459068 1.0 0.7222568418713904 1.2718291468459642 23.570381976449852 -6.769308593316273 1.5770529959241115 0.8405516256419363 1.274842652694201 0.7279108870028008 0.1170343042195465 0.2675570970875038 1.3131579336325667 0.05849773018850521 0.13934007263261636 1.7009494482185717e-07 6.769308593316273 0.43429102705226463 YYTGNYDQYVK(ub)TR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYTGNYDQYVKTR 13 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 10534000.0 2402100.0 4343300.0 3788600.0 True False 3290221.284311668 4151398.644627581 2893810.708666244 1.0 1.2617384321298244 0.8795185668709954 21.649753185212766 -6.722407791114567 1.7509777912790896 1.1588285202873143 0.880044785308319 0.523751450642628 0.1101088324139926 0.3506384869364266 2.102289963702323 0.04990986928084146 0.12492357666021515 1.8949258000301742e-07 6.722407791114567 -0.27878373497899533 YYTGNYDQYVK(ub)TR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YYTGNYDQYVKTR 13 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 14828900.0 4504300.0 6213900.0 4110700.0 True False 3745525.0243236367 6180424.487337422 4970228.364270672 1.0 1.6500822841127532 1.3269777486450491 21.836736530170622 -10.092362877472157 4.488309102934546 0.9999644060299416 1.4885300162281407 0.7529730652818581 0.1319068743668696 91749155.10656066 2.390578299107986 39086.91156945216 0.04515523159450027 8.084201363947517e-11 10.092362877472157 0.4885656101981991 YYTGNYDQYVK(ub)TR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YYTGNYDQYVKTR 13 1 Q9UG63;Q9UG63-2 Q9UG63 ABCF2 ATP-binding cassette sub-family F member 2 1 39743800.0 8210800.0 10820000.0 20713000.0 True False 10629042.459064934 10217857.488455588 16943446.53332744 1.0 0.9613149564325365 1.59407082985893 23.3415082985423 -6.89235627190542 1.0083644525502928 0.967896483336896 1.6510688730478227 0.9823631360952031 0.03845956896649464 0.11725145291576061 0.2108592390882548 0.0289681381406202 0.07285662201519029 1.281279058772409e-07 6.89235627190542 0.6831723897109266 YYTLFGR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YYTLFGR 7 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 15957700.0 5386300.0 4750600.0 5820800.0 False True 7061491.461003401 4041828.997693768 5218519.453056269 1.0 0.5723761077974092 0.7390109415093373 22.75154149731695 -10.257242160772801 5.103335102159694 1.0000557701850774 0.6556935246532533 0.8505773939743472 0.06802838599504984 4.3173666395046236e-05 6.2836473261108955e-06 0.06587884190399917 0.02195606716895547 5.530416495328007e-11 10.257242160772801 -0.34436224553182415 YYTLFGR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYTLFGR 7 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 17429000.0 5386300.0 6888500.0 5154200.0 False True 7377760.669284357 6584143.292776713 3936884.11408107 1.0 0.8924311302463781 0.5336150480553536 22.81475155883984 -6.949045039876889 0.5692309887029301 1.004485334984845 0.40413848952978454 0.9991241963925053 0.005900968417276656 0.08387148537153796 0.03756692290907846 0.0062572119080667584 0.029890812145607265 1.1244883493141582e-07 6.949045039876889 -0.6003468454550605 YYTLFGR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YYTLFGR 7 0 P07814 P07814 EPRS Bifunctional glutamate/proline--tRNA ligase;Glutamate--tRNA ligase;Proline--tRNA ligase 0 10475300.0 4829900.0 3550800.0 2094600.0 False True 4016275.8508493537 3531671.1356213805 2532571.1756638377 1.0 0.8793397831163688 0.6305769996172585 21.93742693098965 -6.959446326996734 0.44316703080073255 1.0086066296793292 0.4915600585281114 0.9997491112520482 0.002436247544709401 0.079899494019631 0.021866518015487585 0.003293144568983769 0.020599625066133827 1.0978769648338761e-07 6.959446326996734 -0.5170465711512178 YYTSASGDEMVSLK ddPTM_RPMI8226_Bortezomib_1h_R1 2 YYTSASGDEMVSLK 14 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 59489200.0 11019300.0 43826300.0 4643600.0 False True 14446409.011053013 37287586.87357937 4163124.816556496 1.0 2.5810972709585105 0.28817713892575453 23.784207586295 -6.721172060775066 1.7550492254163548 1.9607174081520267 0.29150632553006217 0.5180469187792051 0.6652385565514559 0.3530547181092675 2.1259026102607987 0.30088827178807337 0.7543167218849745 1.9003252512105198e-07 6.721172060775066 -1.6692110826219646 YYTSASGDEMVSLK ddPTM_RPMI8226_Bortezomib_2h_R1 2 YYTSASGDEMVSLK 14 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 52200100.0 16112700.0 8019100.0 28068300.0 False True 15601211.158146054 11221168.449054042 20716370.199049328 1.0 0.7192498284464918 1.3278693550809633 23.8951546974032 -6.781287482684114 1.5310258452719783 0.8413001903384495 1.3328729427340935 0.7718830398334054 0.11879070465899118 0.24856803086524693 1.150957308319663 0.06110802801309247 0.1440245317138687 1.654674283691534e-07 6.781287482684114 0.491572752395644 YYTSASGDEMVSLK ddPTM_RPMI8226_Bortezomib_8h_R1 1 YYTSASGDEMVSLK 14 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 105095800.0 0.0 97840000.0 7255800.0 False True 0.0 80379687.57259096 5821687.949669886 0.0 YYTSASGDEMVSLK ddPTM_RPMI8226_Carfilzomib_1h_R1 2 YYTSASGDEMVSLK 14 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 65904900.0 11019300.0 30426100.0 24459500.0 False True 15093432.995385548 29081774.296342246 18682669.85921502 1.0 1.9267832775507927 1.2378012255347604 23.847417647817892 -10.182141314256189 4.630670178773926 0.9999117774212547 1.5822922515445215 0.48780156428461496 0.28127574494204044 197384565.48436812 35.5226971327685 200020.75332095978 0.09628816898269424 6.574438781332325e-11 10.182141314256189 0.5823804741232668 YYTSASGDEMVSLK ddPTM_RPMI8226_Carfilzomib_2h_R1 2 YYTSASGDEMVSLK 14 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 33698360.0 16112700.0 9529060.0 8056600.0 False True 13398423.963639053 9477725.062409675 9741197.810490442 1.0 0.7073761129018264 0.7270405711094324 23.675559972837476 -10.382017720680283 5.821469741539208 1.0000714334218197 0.7172083420056293 0.9963865659416287 0.00802798144615481 7.444771752196416e-06 7.903044354943958e-07 0.007775015889749265 0.002591019870384742 4.149371114546889e-11 10.382017720680283 -0.28286309141619037 YYTSASGDEMVSLK ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YYTSASGDEMVSLK 14 0 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 0 21241600.0 0.0 13377000.0 7864600.0 False True 0.0 12632558.190671936 6433323.497610524 0.0 YYTSASGDEMVSLK(ub)DYCTR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YYTSASGDEMVSLKDYCTR 19 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 22393500.0 3854300.0 8217200.0 10322000.0 True False 5847254.887073881 6750776.4587233635 8281852.175706684 1.0 1.1545206407278115 1.416365856397811 22.479328050379912 -6.963151784202156 0.38847397027554015 0.9836424511038763 1.5966293697130867 0.9998698223590615 0.001960751736261518 0.07859392596521904 0.01710744920795198 0.0033837994248492233 0.02204035199193436 1.0885495830739171e-07 6.963151784202156 0.6129869186092104 YYTSASGDEMVSLK(ub)DYCTR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YYTSASGDEMVSLKDYCTR 19 1 P07900;P07900-2 P07900 HSP90AA1 Heat shock protein HSP 90-alpha 1 23470200.0 3854300.0 6948900.0 12667000.0 True False 4989467.329611484 6562187.606425974 10361735.97439571 1.0 1.3152080518657194 2.076721880289884 22.250454372472362 -6.956190928261007 0.4861559543911012 0.9827394017593658 2.4412722843683206 0.9996017916956469 0.009019369780696335 0.08109097891160331 0.02638075703398516 0.010874756574610421 0.06280900237218642 1.1061373874733484e-07 6.956190928261007 1.4585328826089548 up YYVSK(ub)GLENID ddPTM_RPMI8226_Bortezomib_1h_R1 1 YYVSKGLENID 11 1 O15239 O15239 NDUFA1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 1 12311300.0 2807500.0 4160200.0 5343600.0 True False 3680659.6878686734 3539514.3763325927 4790695.531430641 1.0 0.9616521701255645 1.3015861116474874 21.811532934280923 -6.878870382312316 1.0861172142309625 0.9765717026598241 1.3251576597235175 0.9727611356228771 0.025089027948845006 0.12863368030386638 0.2783932584954453 0.01781240870415799 0.04295273607301058 1.321690041326861e-07 6.878870382312316 0.34858595706369344 YYVSK(ub)GLENID ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYVSKGLENID 11 1 O15239 O15239 NDUFA1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 1 19549600.0 6318100.0 7687800.0 5543700.0 True False 6117535.373853095 10757578.631347382 4091638.6625648793 1.0 1.7584824564033184 0.6688377610455538 22.5445191078495 -6.719542192558242 1.7612124262181255 1.461682269444174 0.6706077512308055 0.5102571776060392 0.319190017642028 0.35620030873349395 2.1591158442274136 0.14392345132285583 0.3614622775038992 1.9074704005082038e-07 6.719542192558242 -0.7910745182133685 YYVSK(ub)GLENID ddPTM_RPMI8226_Bortezomib_8h_R1 1 YYVSKGLENID 11 1 O15239 O15239 NDUFA1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 1 34602500.0 9110500.0 13383000.0 12109000.0 True False 13821294.566766107 10994699.088143744 9715650.842436753 1.0 0.7954898171826079 0.7029479616040056 23.7203894157976 -13.999999999999636 0.10692892284772472 1.9926106965000463 0.5254236070537681 0.9997586736027322 0.001927991871924752 12.031589811865167 0.09871197933639378 2.5938497756302414 0.1578234124094015 1.0000000000008386e-14 13.999999999999636 -1.4671870894462782 YYVSK(ub)GLENID ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYVSKGLENID 11 1 O15239 O15239 NDUFA1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 1 15149700.0 2807500.0 5148200.0 7194000.0 True False 3845508.6198347323 4920735.501179214 5494925.365080762 1.0 1.2796058955110836 1.4289203089387215 21.874742995803814 -11.962916666828995 0.09593724877009946 3.439473855662602e-20 1.8089613156062008 0.9998725312084242 0.0020071483472333114 5.582505292571488 0.07050245221864239 1.4256354217058378 0.2826118822372529 1.089139059157489e-12 11.962916666828995 1.8089613156062008 YYVSK(ub)GLENID ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YYVSKGLENID 11 1 O15239 O15239 NDUFA1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 1 18680100.0 6318100.0 8866200.0 3495800.0 True False 5253780.089287831 8818436.020797094 4226755.617247033 1.0 1.67849355529315 0.8045170420941591 22.324924383283776 -6.699480672711563 1.8327940195715244 1.421529469544739 0.807146926945659 0.4151107857173333 0.2864272906423476 0.396587211742342 2.589624108039131 0.1246957173210212 0.3208815832671833 1.997649667320845e-07 6.699480672711563 -0.6143825425990799 YYVSK(ub)GLENID ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YYVSKGLENID 11 1 O15239 O15239 NDUFA1 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 1 22999500.0 9110500.0 13889000.0 0.0 True False 11793721.844803318 13116064.940587765 0.0 1.0 1.11212262873294 0.0 23.49151573789005 -6.953996686902148 1.1969128759162915 1.0642008130434562 1.8141494095423122e-19 0.9731490753437231 0.08192011926666991 0.10602061418349304 0.30156151395118663 0.0569783224914995 0.10792923463423855 1.1117402083703475e-07 6.953996686902148 -1.0642008130434562 down YYVTIIDAPGHR ddPTM_RPMI8226_Bortezomib_1h_R1 1 YYVTIIDAPGHR 12 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 3995208220.0 1171499350.0 1162510150.0 1661198720.0 False True 1535846992.6658418 989068167.0490738 1489313811.7977207 1.0 0.6439887383132493 0.969701942257053 30.51638735004696 -10.398310549593424 8.333470646169916 1.0000018695789519 0.8068453411090684 0.31921753864485913 0.13297185869156541 4.6188374681283624e-06 3.3359256476184086e-07 0.12875069351757115 0.04291648285222325 3.996588647485629e-11 10.398310549593424 -0.19315652846988351 YYVTIIDAPGHR ddPTM_RPMI8226_Bortezomib_2h_R1 1 YYVTIIDAPGHR 12 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 2683689600.0 791848900.0 506800800.0 1385039900.0 False True 766712090.1056741 709169002.371257 1022256399.8836508 1.0 0.9249482452709384 1.3332989176455474 29.51410968864643 -6.85926799460495 1.1894115978720783 0.9593556733479924 1.352799983914831 0.9527441582165876 0.03857988850860835 0.14756068600468109 0.39708654696825574 0.025305715869007 0.05902395077136887 1.3827128706703206e-07 6.85926799460495 0.3934443105668386 YYVTIIDAPGHR ddPTM_RPMI8226_Bortezomib_8h_R1 1 YYVTIIDAPGHR 12 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 2919437500.0 468190000.0 1798937500.0 652310000.0 False True 710278459.2738291 1477903047.9621582 523380642.5823706 1.0 2.0807375314086385 0.7368668382784153 29.403809492244665 -6.692632400224244 1.8568506145024501 1.6758813323494886 0.7413366055871681 0.3827940732513815 0.4568362345638219 0.41107744488337283 2.749944000869135 0.1966601385868112 0.5104637879086278 2.029399737091594e-07 6.692632400224244 -0.9345447267623205 YYVTIIDAPGHR ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYVTIIDAPGHR 12 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 3067616450.0 1171499350.0 762647100.0 1133470000.0 False True 1604634318.2745442 728950829.385295 865767730.5474122 1.0 0.454278473969778 0.5395420755293132 30.57959741156985 -10.753880509232761 7.010801817793253 1.009465650705843 0.49691027474954563 0.9789117154548311 0.03480871957547221 0.005127145644592224 0.00017999209486060805 0.033553765416936165 0.011234465934884004 1.762460899074502e-11 10.753880509232761 -0.5125553759562974 YYVTIIDAPGHR ddPTM_RPMI8226_Carfilzomib_2h_R1 1 YYVTIIDAPGHR 12 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 1838068800.0 791848900.0 579880000.0 466339900.0 False True 658457445.2041706 576756071.3428324 563849416.9779224 1.0 0.8759200393944901 0.8563186901214054 29.294514964080705 -13.999999999994879 0.25973949111999045 1.907091883240967 0.8491366283711407 0.9995617948889705 0.0013317091982265486 14.405495712820422 0.16127502235277894 6.857608636493137 0.00858116408920618 1.000000000011792e-14 13.999999999994879 -1.0579552548698263 YYVTIIDAPGHR ddPTM_RPMI8226_Carfilzomib_8h_R1 1 YYVTIIDAPGHR 12 0 P68104;Q5VTE0;A0A087WVQ9;A0A087WV01;A6PW80;Q5JR01 P68104 EEF1A1;EEF1A1P5 Elongation factor 1-alpha 1;Putative elongation factor 1-alpha-like 3;Elongation factor 1-alpha 0 2387660000.0 468190000.0 1210390000.0 709080000.0 False True 606081184.404639 1143030732.4816792 580034715.775205 1.0 1.8859366729961966 0.9570247859533542 29.174935814337115 -6.656935303013634 1.984276077349613 1.5717053775590666 0.9609480500557286 0.22254737873550479 0.3774905482059481 0.49168335552801645 3.7184008932330688 0.15389285170313405 0.418207608487976 2.2032546581506516e-07 6.656935303013634 -0.610757327503338 YYYQGCASWK ddPTM_RPMI8226_Bortezomib_1h_R1 1 YYYQGCASWK 10 0 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 0 12863500.0 5236300.0 2538900.0 5088300.0 False True 6864840.008401335 2160106.016554687 4561811.5264201155 1.0 0.3146622519841838 0.6645182583770743 22.71079466671393 -10.63785113030351 6.703533730551346 1.001906521880628 0.48959025518117 0.7394412366416996 0.1428281165184119 0.004081348306374336 0.00022048882889494443 0.13868894191420236 0.04609757638716518 2.3022308527002135e-11 10.63785113030351 -0.5123162666994581 YYYQGCASWK ddPTM_RPMI8226_Carfilzomib_1h_R1 1 YYYQGCASWK 10 0 Q9H0D6;Q9H0D6-2 Q9H0D6 XRN2 5-3 exoribonuclease 2 0 10268500.0 5236300.0 2701700.0 2330500.0 False True 7172301.615686776 2582329.960672837 1780083.8981541158 1.0 0.3600420198482644 0.24818865596238116 22.77400472823682 -13.999999999999998 0.24536092547276267 5.34863908965403 0.20118693655808895 0.9995341892368028 0.007148304178529983 13.81881409419297 0.15675338735386235 29.5365061546882 0.05298576285404603 1.0000000000000041e-14 13.999999999999998 -5.147452153095942